FrancophonIA/ELRC3.0 huggingface dataset:
English: This effect is not clinically meaningful, and no dose adjustment for co-administered CYP3A4 substrates is necessary during tedizolid phosphate treatment.
Slovenian: Ta učinek ni klinično pomemben in zato med zdravljenjem s tedizolid fosfatom prilagoditev odmerkov sočasno uporabljenih substratov CYP3A4 ni potrebna.
English: In Phase 3 studies, subjects taking serotonergic agents including antidepressants such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and serotonin 5-hydroxytryptamine (5-HT1) receptor agonists (triptans), meperidine, or buspirone were excluded.
Slovenian: Preiskovanci, ki so jemali serotoninergična zdravila, vključno z antidepresivi, kot so selektivni zaviralci ponovnega privzema serotonina (SSRI) in triciklični antidepresivi, ter agoniste serotoninskih receptorjev 5-hidroksitriptamina (5-HT1) (triptane), meperidin ali buspiron, so bili iz študij 3. faze izključeni.
English: Following administration of a single 200 mg oral dose of tedizolid phosphate, the pharmacokinetics of tedizolid are not altered in patients with moderate (n=8) or severe (n=8) hepatic impairment (Child-Pugh Class B and C).
Slovenian: Po zaužitju enkratnega 200 mg peroralnega odmerka tedizolid fosfata se farmakokinetika tedizolida pri bolnikih z zmerno (n = 8) ali hudo (n = 8) okvaro jeter (razred B in C po Child-Pughu) ne spremeni.
English: These dose levels equate to exposure margins of ≥ 5.3-fold for males and ≥ 4.2-fold for females relative to tedizolid plasma AUC0-24 levels at the human oral therapeutic dose.
Slovenian: Te velikosti odmerkov ustrezajo robu izpostavljenosti, ki je pri moških ≥ 5,3-krat in pri ženskah ≥ 4,2-krat večji v primerjavi s plazemskimi vrednostmi AUC0-24 tedizolida pri peroralnem terapevtskem odmerku pri človeku.
English: Polyvinyl alcohol Titanium dioxide (E171) Macrogol
Slovenian: Filmska obloga polivinilalkohol titanov dioksid (E171) makrogol smukec rumeni železov oksid (E172)
English: The Cmax and AUC of tedizolid increased approximately dose proportionally within the single oral dose range of 200 mg to 1,200 mg and across the intravenous dose range of 100 mg to 400 mg. Steady-state concentrations are achieved within 3 days and indicate modest active substance accumulation of approximately 30% following multiple once-daily oral or intravenous administration as predicted by a half-life of approximately 12 hours.
Slovenian: Vrednosti Cmax in AUC tedizolida naraščata približno sorazmerno z odmerkom v razponu enkratnih peroralnih odmerkov od 200 mg do 1.200 mg in v razponu intravenskih odmerkov od 100 mg do 400 mg. Koncentracije v stanju dinamičnega ravnovesja so dosežene v 3 dneh in nakazujejo zmerno, približno 30 % kopičenje učinkovine po večkratnem enkrat dnevnem odmerjanju ali intravenski aplikaciji, kar ustreza pričakovanjem glede na razpolovni čas, ki je približno 12 ur.
English: • Hot flush or blushing/redness in the face, neck or upper chest
Slovenian: • vročinski oblivi ali zardevanje/rdečica na obrazu, vratu ali zgornjem delu prsnega koša
English: A special neuropathology study was conducted in pigmented Long Evans rats administered tedizolid phosphate daily for up to 9 months.
Slovenian: Pri pigmentiranih podganah vrste Long Evans so opravili posebno nevropatološko študijo, v kateri so živali do 9 mesecev dnevno prejemale tedizolid fosfat.
English: Effects of other medicines on Sivextro
Slovenian: Vplivi drugih zdravil na zdravilo Sivextro
English: It must be administered as an intravenous infusion only.
Slovenian: Zdravilo se sme aplicirati samo z intravensko infuzijo.
English: Clostridioides difficile associated diarrhoea
Slovenian: Diareja, povezana z bakterijo Clostridioides difficile
English: The safety and efficacy of tedizolid phosphate when administered for periods longer than 6 days have not been established.
Slovenian: Varnost in učinkovitost tedizolid fosfata pri uporabi, daljši od 6 dni, nista bili dokazani.
English: Reconstitute the contents of the vial with 4 mL water for injections, and swirl gently until the powder has dissolved entirely.
Slovenian: Vsebino viale rekonstituirajte s 4 ml vode za injekcije in vialo nežno obračajte, dokler se prašek popolnoma ne raztopi.
English: Peak plasma tedizolid concentrations are achieved within approximately 3 hours after dosing after oral administration of tedizolid phosphate under fasted conditions.
Slovenian: Najvišje koncentracije tedizolida v plazmi so dosežene v približno 3 urah po peroralnem odmerjanju tedizolid fosfata na tešče.
English: Urine odor abnormal
Slovenian: Bolezni sečil nenormalen vonj urina
English: • Poor control of diabetes
Slovenian: • slabo urejena sladkorna bolezen
English: The no observed adverse effect levels (NOAELs) for foetal toxicity in mice (5 mg/kg/day) as well as maternal and foetal toxicity in rats (2.5 mg/kg/day) were associated with tedizolid plasma area under the curve (AUC) values approximately equivalent to the tedizolid AUC value associated with the oral human therapeutic dose.
Slovenian: Ravni, pri katerih ni bilo opaznih neželenih učinkov (NOAEL - no observed adverse effect levels) za toksičnost za plod pri miših (5 mg/kg/dan) ter toksičnost za mater in plod pri podganah (2,5 mg/kg/dan), so bile povezane z vrednostmi površine pod krivuljo plazemske koncentracije (AUC) tedizolida, ki so bile približno enakovredne vrednostim AUC tedizolida pri uporabi peroralnega terapevtskega odmerka pri človeku.
English: Adverse reactions such as lactic acidosis, anaemia and neuropathy (optic and peripheral) may occur as a result of this inhibition.
Slovenian: Posledica tega zaviranja je lahko pojav neželenih učinkov, kot so laktacidoza, anemija in nevropatija (optična in periferna).
English: What you need to know before you are given Sivextro
Slovenian: Kaj morate vedeti, preden boste prejeli zdravilo Sivextro
English: Repeated oral and intravenous dosing of tedizolid phosphate in rats in 1-month and 3-month toxicology studies produced dose- and time-dependent bone marrow hypocellularity (myeloid, erythroid, and megakaryocyte), with associated reduction in circulating RBCs, WBCs, and platelets.
Slovenian: Ponavljajoče se peroralno in intravensko odmerjanje tedizolid fosfata pri podganah v 1-in 3-mesečni toksikološki študiji je povzročilo od odmerka in časa odvisno hipocelularnost kostnega mozga (mieloidne, eritroidne in megakariocitne celice), ki jo je spremljalo zmanjšanje števila eritrocitov, levkocitov in trombocitov v obtoku.
English: The mean steady state volume of distribution of tedizolid in healthy adults (n=8) following a single intravenous dose of tedizolid phosphate 200 mg ranged from 67 to 80 L.
Slovenian: Povprečni volumen porazdelitve tedizolida v stanju dinamičnega ravnovesja po enkratnem 200 mg intravenskem odmerku tedizolid fosfata pri zdravih odraslih (n = 8) je bil v razponu od 67 do 80 l.
English: In embryo-foetal studies, tedizolid phosphate was shown to produce foetal developmental toxicities in mice and rats.
Slovenian: V študijah na zarodkih in plodovih je imel tedizolid fosfat škodljive učinke na razvoj plodu pri miših in podganah.
English: The following adverse reactions have been identified in two comparative pivotal Phase 3 studies with Sivextro (Table 1).
Slovenian: V dveh primerjalnih ključnih študijah 3. faze z zdravilom Sivextro so ugotovili naslednje neželene učinke (preglednica 1).
English: Type I (10 ml) clear borosilicate tubing glass vial with a siliconised grey chlorobutyl rubber stopper.
Slovenian: 10-ml viala iz prozornega borosilikatnega cevastega stekla tipa I s sivim klorobutil silikoniziranim gumijastim zamaškom.
English: Tedizolid phosphate was negative for genotoxicity in all in vitro assays (bacterial reverse mutation [Ames], Chinese hamster lung [CHL] cell chromosomal aberration) and in all in vivo tests (mouse bone marrow micronucleus, rat liver unscheduled DNA synthesis).
Slovenian: Tedizolid fosfat ni izkazal genotoksičnosti v nobenem preskusu in vitro (bakterijske povratne mutacije [Ames], kromosomske aberacije v pljučnih celicah kitajskega hrčka) in v nobenem preskusu in vivo (mikrojedra v mišjem kostnem mozgu, nenačrtovana sinteza DNK v podganjih jetrnih celicah).
English: The reconstituted solution will be withdrawn from the vial and added to an infusion bag of 0.9% sodium chloride in the hospital.
Slovenian: V bolnišnici se pripravljena raztopina odvzame iz viale in doda v infuzijsko vrečko z 0,9 % raztopino natrijevega klorida.
English: Tedizolid is bacteriostatic against enterococci, staphylococci, and streptococci in vitro.
Slovenian: In vitro je tedizolid bakteriostatičen proti enterokokom, stafilokokom in streptokokom.
English: Serotonergic effects at doses of tedizolid phosphate up to 30-fold above the human equivalent dose did not differ from vehicle control in a mouse model that predicts brain serotonergic activity.
Slovenian: Pri mišjem modelu, ki napoveduje serotoninergično delovanje v možganih, se pri odmerkih tedizolid fosfata, do 30-krat večjih od enakovrednega odmerka pri ljudeh, serotoninergični učinki niso razlikovali od kontrole z vehiklom.
English: • Dry mouth, constipation, indigestion, pain/discomfort in the belly (abdomen), retching, dry heaving, bright red blood in the stool
Slovenian: • suha usta, zaprtost, prebavne motnje, bolečine/neprijeten občutek v trebuhu, siljenje na bruhanje, sprožanje refleksa bruhanja, svetlo rdeča kri v blatu
English: • Joint pain, muscle spasms, back pain, neck pain, pain/discomfort in limbs, decrease of grip strength
Slovenian: • bolečine v sklepih, mišični krči, bolečine v hrbtu, bolečine v vratu, bolečine/neprijeten občutek v okončinah, zmanjšanje moči prijema
English: What you need to know before you take Sivextro
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Sivextro
English: Therefore, orally administered Sivextro can result in inhibition of BCRP at the intestinal level.
Slovenian: Pri peroralni uporabi zdravila Sivextro lahko zato pride do zaviranja BCRP na črevesni ravni.
English: These events have been observed with another member of the oxazolidinone class when administered over a duration exceeding that recommended for tedizolid phosphate.
Slovenian: Te učinke so opazili pri uporabi drugega zdravila iz skupine oksazolidinonov, ko so ga uporabljali dlje, kot je priporočeno za tedizolid fosfat.
English: • Fungal infections of skin , mouth and vagina (oral / vaginal thrush)
Slovenian: • glivične okužbe kože, ust in nožnice (ustne/vaginalne "gobice")
English: Myelosuppression (including anaemia, leucopenia, pancytopenia and thrombocytopenia) has been reported in patients treated with another member of the oxazolidinone class and the risk of these effects appeared to be related to the duration of treatment.
Slovenian: O mielosupresiji (vključno z anemijo, levkopenijo, pancitopenijo in trombocitopenijo) so poročali pri bolnikih, ki so se zdravili z drugim zdravilom iz skupine oksazolidinonov.
English: In ABSSSI, the types of infections treated were confined to cellulitis/erysipelas or major cutaneous abscesses, and wound infections only.
Slovenian: Pri akutnih bakterijskih okužbah kože in mehkih tkiv so bile zdravljene vrste okužb omejene samo na celulitis/šen ali večje kožne abscese in okužbe ran.
English: What Sivextro looks like and contents of the pack Sivextro is a white to off-white powder for concentrate for solution for infusion in a glass vial.
Slovenian: Zdravilo Sivextro je bel do skoraj bel prašek za koncentrat za raztopino za infundiranje v stekleni viali.
English: Oral and intravenous tedizolid phosphate is a prodrug that is rapidly converted by phosphatases to tedizolid, the microbiologically active moiety.
Slovenian: Peroralni in intravenski tedizolid fosfat je predzdravilo, ki ga fosfataze hitro pretvorijo v mikrobiološko aktivni tedizolid.
English: Adrenergic agents
Slovenian: Adrenergične učinkovine
English: • Itching (including itching due to allergic reaction), hair loss, acne, red and/or itchy rash or hives,
Slovenian: • srbenje (vključno s srbenjem zaradi alergijske reakcije), izpadanje las, akne, rdeč in/ali srbeč izpuščaj ali koprivnica, prekomerno znojenje
English: Vulvovaginal pruritus
Slovenian: Okvara ledvic
English: Therefore, orally administered tedizolid phosphate can result in inhibition of BCRP at the intestinal level.
Slovenian: Pri peroralni uporabi tedizolid fosfata lahko zato pride do zaviranja BCRP na črevesni ravni.
English: Monoamine oxidase inhibition
Slovenian: Zaviranje monoaminooksidaze
English: Sivextro 200 mg film-coated tablets
Slovenian: Sivextro 200 mg filmsko obložene tablete
English: If you are given more Sivextro than you should Tell your doctor or nurse immediately if you are concerned that you may have been given too much Sivextro.
Slovenian: Če ste prejeli večji odmerek zdravila Sivextro, kot bi smeli Če vas skrbi, da ste morda prejeli preveč zdravila Sivextro, se takoj posvetujte z zdravnikom ali medicinsko sestro.
English: No dosage adjustment is required (see section 5.2).
Slovenian: Prilagoditev odmerka ni potrebna (glejte poglavje 5.2).
English: It is available in 6 × 1 tablets in perforated unit-dose blisters.
Slovenian: Na voljo je v perforiranih deljivih pretisnih omotih s posameznimi odmerki, ki vsebujejo 6 x 1 tableto.
English: A clinical study comparing the single dose (2 mg) pharmacokinetics of midazolam (CYP3A4 substrate) alone or in combination with tedizolid phosphate (once-daily 200 mg oral dose for 10 days), demonstrated no clinically meaningful difference in midazolam Cmax or AUC.
Slovenian: Klinična študija, v kateri so primerjali farmakokinetiko enkratnih odmerkov (2 mg) midazolama (substrat CYP3A4) samega ali v kombinaciji s tedizolid fosfatom (200-mg peroralni odmerek enkrat dnevno 10 dni), ni pokazala klinično pomembne razlike v Cmax ali AUC midazolama.
English: If you forget to take your medicine, take the dose as soon as possible anytime up to 8 hours prior to the next scheduled dose.
Slovenian: Če ste pozabili vzeti odmerek, ga vzemite čim prej, in sicer kadar koli do najmanj 8 ur pred naslednjim načrtovanim odmerkom.
English: There are limited data in patients on the interaction between serotonergic agents and tedizolid phosphate.
Slovenian: Podatkov o medsebojnem delovanju serotoninergičnih zdravil in tedizolid fosfata pri bolnikih je malo.
English: 6 × 1 tablets in aluminum/Polyethylene Terephthalate (PET)/Paper foil and polyvinyl chloride (PVC)/polyvinylidene chloride (PVdC) clear film perforated child-resistant unit-dose blisters.
Slovenian: 6 x 1 tableta v perforiranih za otroke varnih deljivih pretisnih omotih s posameznimi odmerki iz aluminijaste/polietilen tereftalatne (PET)/papirne folije in prosojne folije iz polivinilklorida (PVC)/polivinilidenklorida (PVdC).
English: The following adverse reactions have been identified in two comparative pivotal Phase 3 studies and one post-authorisation study with Sivextro (Table 1).
Slovenian: V dveh primerjalnih ključnih študijah 3. faze in eni študiji po pridobitvi dovoljenja za promet z zdravilom Sivextro so ugotovili naslednje neželene učinke (preglednica 1).
English: Tedizolid phosphate is converted by endogenous plasma and tissue phosphatases to the microbiologically active moiety, tedizolid.
Slovenian: Endogene fosfataze v plazmi in tkivih pretvorijo tedizolid fosfat v mikrobiološko aktivni tedizolid.
English: Contact your doctor, pharmacist or nearest hospital casualty department as soon as possible if you have taken more tablets than you should, and take your medicine with you.
Slovenian: Če ste vzeli večji odmerek zdravila Sivextro, kot bi smeli Če ste vzeli več tablet, kot bi smeli, čim prej obiščite zdravnika, farmacevta ali nezgodni oddelek najbližje bolnišnice in vzemite zdravilo s seboj.
English: What Sivextro is and what it is used for What you need to know before you take Sivextro How to take Sivextro
Slovenian: Kaj je zdravilo Sivextro in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Sivextro Kako jemati zdravilo Sivextro Možni neželeni učinki
English: What Sivextro contains
Slovenian: Kaj vsebuje zdravilo Sivextro
English: At steady state, tedizolid mean (SD) Cmax values of 2.2 (0.6) and 3.0 (0.7) mcg/mL and AUC values of 25.6 (8.5) and 29.2 (6.2) mcg·h/mL were similar with oral and IV administration of tedizolid phosphate, respectively.
Slovenian: 2,2 (0,6) oziroma 3,0 (0,7) µg/ml in vrednosti AUC 25,6 (8,5) oziroma 29,2 (6,2) µg·h/ml.
English: Each film-coated tablet contains 200 mg tedizolid phosphate.
Slovenian: Ena filmsko obložena tableta vsebuje 200 mg tedizolid fosfata.
English: Safety was additionally evaluated in a randomized, double-blind, multicenter study conducted in China, the Philippines, Taiwan, and the US, which included a total 292 adult patients treated with tedizolid phosphate 200 mg administered IV and/or oral once daily for 6 days, and 297 patients treated with linezolid 600 mg administered IV and/or oral every 12 hours for 10 days for ABSSSI.
Slovenian: Študija je vključevala skupno 292 odraslih bolnikov, zdravljenih z 200 mg tedizolid fosfata intravensko in/ali peroralno enkrat dnevno 6 dni, in 297 bolnikov, zdravljenih s 600 mg linezolida intravensko in/ali peroralno vsakih 12 ur 10 dni, za zdravljenje akutnih bakterijskih okužb kože in mehkih tkiv.
English: If less than 8 hours remains before the next dose, then the physician should wait until the next scheduled dose.
Slovenian: Če je do naslednjega odmerka manj kot 8 ur, mora zdravnik počakati do naslednjega načrtovanega odmerka.
English: C-labeled tedizolid phosphate under fasted conditions, the majority of elimination occurred via the liver with 81.5% of the radioactive dose recovered in faeces and 18% in urine, with most of the elimination (>85%) occurring within 96 hours.
Slovenian: 81,5 % radioaktivnega odmerka se je izločilo v blatu in 18 % v urinu.
English: Tedizolid was positive in an in vitro CHL cell chromosomal aberration assay, but negative for genotoxicity in other in vitro assays (Ames, mouse lymphoma mutagenicity) and in vivo in a mouse bone marrow micronucleus assay.
Slovenian: Medtem ko je bil v preskusu in vitro s kromosomskimi aberacijami v pljučnih celicah kitajskega hrčka rezultat pozitiven, je bil negativen za genotoksičnost v drugih preskusih in vitro (Ames, mutagenost v mišjem limfomu) in v preskusu z mikrojedri v mišjem kostnem mozgu in vivo.
English: The pharmacokinetics of tedizolid in elderly healthy volunteers (age 65 years and older, with at least 5 subjects at least 75 years old; n=14) was comparable to younger control subjects (25 to 45 years old; n=14) following administration of a single oral dose of tedizolid phosphate 200 mg.
Slovenian: Po zaužitju enkratnega 200 mg peroralnega odmerka tedizolid fosfata je bila farmakokinetika tedizolida pri starejših zdravih prostovoljcih (starih 65 let in več, med katerimi je bilo najmanj 5 preiskovancev starih vsaj 75 let, n = 14) primerljiva kot pri mlajših preiskovancih iz kontrolne skupine (od 25 do 45 let, n = 14).
English: Dysgeusia Tremor Paraesthesia Hypoaesthesia
Slovenian: Bolezni živčevja glavobol zaspanost omotica disgevzija tremor parestezija hipestezija
English: How to take Sivextro
Slovenian: Kako jemati zdravilo Sivextro
English: After reconstitution each mL contains 50 mg tedizolid phosphate.
Slovenian: Po rekonstituciji en ml vsebuje 50 mg tedizolid fosfata.
English: • Nausea
Slovenian: • bruhanje
English: Clostridioides difficile associated diarrhoea (CDAD) has been reported for tedizolid phosphate (see section 4.8).
Slovenian: Pri uporabi tedizolid fosfata so poročali o pojavu diareje, povezane z bakterijo Clostridioides difficile (CDAD - Clostridioides difficile associated diarrhoea) (glejte poglavje 4.8).
English: Sivextro 200 mg powder for concentrate for solution for infusion
Slovenian: Sivextro 200 mg prašek za koncentrat za raztopino za infundiranje
English: If less than 8 hours remains before the next dose, then wait until the next scheduled dose.
Slovenian: Če je do naslednjega odmerka manj kot 8 ur, počakajte do naslednjega načrtovanega odmerka.
English: Sodium hydroxide (for pH adjustment) Hydrochloric acid (for pH adjustment)
Slovenian: 6.1 Seznam pomožnih snovi manitol natrijev hidroksid (za uravnavanje pH) klorovodikova kislina (za uravnavanje pH)
English: No evidence of neurotoxicity, including neurobehavioral changes or optic or peripheral neuropathy, was associated with tedizolid after 1, 3, 6 or 9 months of oral administration up to doses with plasma exposure levels (AUC) up to 8-fold greater than the expected human plasma exposure at the oral therapeutic dose.
Slovenian: Po 1, 3, 6 ali 9 mesecih peroralnega odmerjanja, tudi s tako velikimi odmerki, da je bila plazemska izpostavljenost (AUC) do 8-krat večja od pričakovane plazemske izpostavljenosti pri človeku po peroralnem terapevtskem odmerku, niso s tedizolidom povezali nobenih znakov nevrotoksičnosti, vključno z nevrovedenjskimi spremembami in optično ali periferno nevropatijo.
English: Tedizolid is a reversible inhibitor of MAO in vitro; however, no interaction is anticipated when comparing the IC50 and the anticipated plasma exposures in man. No evidence of MAO-A inhibition was observed in Phase 1 studies specifically designed to investigate the potential for this interaction.
Slovenian: Tedizolid je reverzibilen zaviralec monoaminooksidaze (MAO) in vitro, vendar ni pričakovati medsebojnega delovanja, če primerjamo vrednost IC50 za zaviranje MAO-A in pričakovano plazemsko izpostavljenost pri ljudeh.
English: For administration, the reconstituted solution must be further diluted in 250 mL 0.9% sodium chloride.
Slovenian: Za uporabo pri bolniku je treba rekonstituirano raztopino dodatno razredčiti v 250 ml 0,9-odstotne raztopine natrijevega klorida.
English: • Dryness in the nose, congestion in the chest, cough
Slovenian: • suhost nosne sluznice, nabiranje sluzi v pljučih, kašelj
English: If a dose is missed it should be given to the patient as soon as possible anytime up to 8 hours prior to the next scheduled dose.
Slovenian: Če bolnik izpusti odmerek, ga mora prejeti čim prej, in sicer kadar koli do 8 ur pred naslednjim načrtovanim odmerkom.
English: Renal impairment No dosage adjustment is required (see section 5.2).
Slovenian: Okvara ledvic Prilagoditev odmerka ni potrebna (glejte poglavje 5.2).
English: If you miss a dose of Sivextro Tell your doctor or nurse immediately if you are concerned that you may have missed a dose.
Slovenian: Če niste prejeli odmerka zdravila Sivextro Če vas skrbi, da niste prejeli odmerka zdravila, se takoj posvetujte z zdravnikom ali medicinsko sestro.
English: If possible, an interruption of the co-administered BCRP substrate medicinal product (such as imatinib, lapatinib, methotrexate, pitavastatin, rosuvastatin, sulfasalazine, and topotecan) should be considered during the 6 days of treatment with oral tedizolid phosphate.
Slovenian: Če je mogoče, je treba tekom šest-dnevnega zdravljenja s peroralno obliko tedizolid fosfata razmisliti o prekinitvi sočasne uporabe zdravila, ki je substrat BCRP (kot so imatinib, lapatinib, metotreksat, pitavastatin, rosuvastatin, sulfasalazin in topotekan).
English: Sivextro 200 mg tablets tedizolid phosphate
Slovenian: Sivextro 200 mg tablete tedizolid fosfat
English: A second resistance mechanism is encoded by a plasmid-borne and transposon associated chloramphenicol-florfenicol resistance (cfr) gene, conferring resistance in staphylococci and enterococci to oxazolidinones, phenicols, lincosamides, pleuromutilins, streptogramin A and 16membered macrolides.
Slovenian: Ta gen omogoča stafilokokom in enterokokom odpornost na oksazolidinone, fenikole, linkozamide, plevromutiline, streptogramine A in 16-členske makrolide.
English: How you will be given Sivextro
Slovenian: Kako boste prejeli zdravilo Sivextro
English: Multiple sulfotransferase (SULT) enzymes (SULT1A1, SULT1A2, and SULT2A1) are involved in the biotransformation of tedizolid, to form an inactive and non-circulating sulphate conjugate found in the excreta.
Slovenian: V biotransformacijo tedizolida je vključenih več encimov sulfotransferaz (SULT1A1, SULT1A2 in SULT2A1).
English: The highest single dose administered in clinical studies was 1,200 mg. All adverse reactions at this dose level were mild or moderate in severity.
Slovenian: Največji enkratni odmerek v kliničnih študijah je bil 1.200 mg.