FrancophonIA/ELRC3.0 huggingface dataset:
English: Ritonavir is predominantly metabolised by CYP3A and to a lesser extent, by CYP2D6.
Danish: Ritonavir metaboliseres hovedsagelig af CYP3A og i mindre omfang af CYP2D6.
English: D168Y V36Ac, V36Mc, F43Lc, D168H, E357Kc NS5A M28T M28Ve Q30Re Y93H H58D, H58P, Y93N NS5B A553T S556G C316Y, M414T, G554S, S556R, G558R, D559G, D559N, Y561H a. Observed in at least 2 subjects of the same subtype.
Danish: D168Y V36Ac, V36Mc, F43Lc, D168H, E357Kc NS5A M28T M28Ve Q30Re Y93H H58D, H58P, Y93N NS5B A553T S556G C316Y, M414T, G554S, S556R, G558R, D559G, D559N, Y561H a. Observeret hos mindst 2 forsøgspersoner med samme undertype.
English: The recommended oral dose of Viekirax is two 12.5 mg / 75 mg / 50 mg tablets once daily with food.
Danish: Den anbefalede orale dosis Viekirax er to 12,5 mg / 75 mg / 50 mg-tabletter én gang dagligt sammen med mad.
English: Viekirax without ribavirin and without dasabuvir was also evaluated in genotype 1b infected subjects in Phase 2 studies M13-393 (PEARL-I) and M12-536.
Danish: Viekirax uden ribavirin og uden dasabuvir blev også undersøgt hos genotype 1b-smittede forsøgspersoner i fase 2-studierne M13-393 (PEARL I) og M12-536.
English: You should not breast-feed during treatment with Viekirax.
Danish: Du må ikke amme under behandlingen med Viekirax.
English: Ombitasvir had no effect on fertility when evaluated in mice.
Danish: Ombitasvir havde ingen indvirkning på fertiliteten hos mus.
English: The combined action of the three active substances stops the hepatitis C virus from multiplying and infecting new cells, thus clearing the virus from your blood over a period of time.
Danish: Den kombinerede virkning af de tre aktive stoffer forhindrer hepatitis C-virusset i at formere sig og smitte nye celler.
English: Lopinavir/ritonavir 800/200 mg once daily (administered in the evening) was also administered with Viekirax with or without dasabuvir.
Danish: Lopinavir/ritonavir 800/200 mg én gang dagligt (om aftenen) blev også administreret med Viekirax med eller uden dasabuvir.
English: ALT elevations were asymptomatic and generally occurred during the first 4 weeks of treatment, without concomitant elevations of bilirubin, and declined within approximately two weeks of onset with continued dosing of Viekirax and dasabuvir with or without ribavirin.
Danish: Det forhøjede ALAT-niveau var asymptomatisk og optrådte som regel i løbet af de første 4 behandlingsuger uden samtidig bilirubinforhøjelse og faldt igen i løbet af ca. 2 uger ved fortsat behandling med Viekirax og dasabuvir med eller uden ribavirin.
English: Theoretically, Viekirax with and without dasabuvir is expected to increase the exposure to pitavastatin and fluvastatin.
Danish: Teoretisk set forventes Viekirax med eller uden dasabuvir at øge eksponeringen for pitavastatin og fluvastatin.
English: Three interrupted Viekirax and dasabuvir for one to seven days, including one on ethinyloestradiol.
Danish: Tre afbrød behandlingen med Viekirax og dasabuvir i 1-7 dage, herunder én, der fik ethinyløstradiol.
English: Patients who are taking ethinyloestradiol-containing medicinal products (i.e. most combined oral contraceptives or contraceptive vaginal rings) must switch to an alternative method of contraception (e.g., progestin only contraception or non-hormonal methods) prior to initiating Viekirax with or without dasabuvir therapy (see sections 4.3 and 4.5).
Danish: Patienter, der tager ethinyløstradiol-holdige lægemidler (dvs. de fleste kombinerede p-piller og p-ringe), skal skifte til en alternativ præventionsmetode (f.eks. prævention med gestagen alene eller ikkehormonelle metoder), inden de starter behandling med Viekirax med eller uden dasabuvir (se pkt.
English: Not studied; No interaction expected when gemfibrozil is used in combination with Viekirax without dasabuvir.
Danish: Ikke undersøgt: Ingen interaktion forventes, når gemfibrozil gives i kombination med Viekirax uden dasabuvir.
English: Ombitasvir, paritaprevir and ritonavir should be administered with food.
Danish: Ombitasvir, paritaprevir og ritonavir skal administreres sammen med mad.
English: TURQUOISE-II: Relapse Rates by Baseline Laboratory Values after 12 and 24 Weeks of Treatment in Subjects with Genotype 1a Infection and Compensated Cirrhosis
Danish: TURQUOISE II: Recidivrate ud fra laboratorieværdier ved baseline efter 12 og 24 ugers behandling hos patienter med genotype 1a-infektion og kompenseret cirrose
English: Co-administration may result in increased risk for adverse events.
Danish: Samtidig administration kan forøge risikoen for bivirkninger.
English: Examples of contraindicated strong CYP3A4 inhibitors are provided below.
Danish: Eksempler på kontraindicerede stærke CYP3A4-hæmmere er angivet nedenfor:
English: Expected: ↑ ergot derivatives
Danish: Forventet: ↑ Sekale-derivater
English: 10 of 34 subjects (29.4%) dose modified ribavirin due to decrease in haemoglobin and 2.9% (1/34) had an interruption of ribavirin.
Danish: 10 ud af 34 forsøgspersoner (29,4 %) fik nedsat ribavirin-dosen på grund af fald i hæmoglobin-niveauet, og 2,9 % (1/34) fik afbrudt behandlingen med ribavirin.
English: In the presence of ombitasvir, paritaprevir exposures were minimally affected (5% to 27% change) while dasabuvir exposures increase by approximately 30%.
Danish: Når ombitasvir var til stede, faldt eksponeringen for paritaprevir minimalt (ændring på 5-27 %), mens eksponeringen for dasabuvir steg med ca. 30 %.
English: Clinical trials in peginterferon+ribavirin-experienced adults
Danish: Kliniske studier hos peginterferon+ribavirin-erfarne voksne
English: Therefore, Viekirax with or without dasabuvir is not expected to affect medicinal products which are primarily excreted by the renal route via these transporters (see section 5.2).
Danish: Viekirax med eller uden dasabuvir forventes derfor ikke at påvirke lægemidler, der primært udskilles gennem nyrerne via disse transportere (se pkt.
English: Ombitasvir has shown malformations in rabbits at maximal feasible exposures 4-fold higher than the AUC exposure at recommended clinical dose.
Danish: Ombitasvir har vist misdannelser hos kaniner ved den størst mulige eksponering, der er 4 gange højere end eksponeringen målt ud fra AUC ved den anbefalede kliniske dosis.
English: Recommended co-administered medicinal product(s) and treatment duration for Viekirax by patient population
Danish: Anbefalede samtidige lægemidler og anbefalet behandlingsvarighed for Viekirax for hver patientpopulation
English: In the presence of paritaprevir/ritonavir, dasabuvir exposures decreased by approximately 50% to 60% while ombitasvir exposures increased by 31-47%.
Danish: Når paritaprevir/ritonavir var til stede, faldt eksponeringen for dasabuvir med ca. 50-60 %, mens eksponeringen for ombitasvir steg med 31-47 %.
English: Viekirax tablets are pink, oblong film-coated tablets of dimmensions 18.8 mm x 10.0 mm, marked with ‘AV1'.
Danish: Viekirax-tabletterne er lyserøde, aflange filmovertrukne tabletter på 18,8 mm x 10,0 mm præget med "AV1".
English: These ALT elevations were significantly more frequent in the subgroup of subjects who were using ethinyloestradiol-containing medicinal products such as combined oral contraceptives or contraceptive vaginal rings (6 of 25 subjects); (see section 4.3).
Danish: Forhøjet ALAT sås signifikant hyppigere i den undergruppe, der brugte ethinyløstradiol-holdige lægemidler som f.eks. kombinerede p-piller eller p-ringe (6 ud af 25 forsøgspersoner) (se pkt.
English: Patients should be informed that fatigue has been reported during treatment with Viekirax in combination with dasabuvir and ribavirin (see section 4.8).
Danish: Patienterne skal informeres om, at der er rapporteret om træthed ved behandling med Viekirax i kombination med dasabuvir og ribavirin (se pkt.
English: The interaction between Viekirax with or without dasabuvir and colchicine has not been evaluated.
Danish: Interaktionen mellem Viekirax med eller uden dasabuvir og colchicin er ikke undersøgt.
English: If tacrolimus with Viekirax and dasabuvir are used concomitantly, tacrolimus should not be administered on the day Viekirax and dasabuvir are initiated.
Danish: Hvis tacrolimus og Viekirax med dasabuvir bruges samtidigt, bør tacrolimus ikke administreres på dagen, hvor Viekirax med dasabuvir behandling indledes.
English: In Phase 3 clinical trials, 1075 subjects (including 181 with compensated cirrhosis) with genotype 1 HCV infection received the recommended regimen (see section 4.2).
Danish: I kliniske fase 3-studier fik 1.075 patienter med HCV genotype 1-infektion (herunder 181 med kompenseret cirrose) det anbefalede regime (se pkt.
English: However, co-administration of digoxin with Viekirax without dasabuvir may result in increased plasma concentrations (see Table 2).
Danish: Samtidig administration af digoxin og Viekirax uden dasabuvir kan imidlertid give øgede plasmakoncentrationer (se tabel 2).
English: CYP3A substrates evaluated in drug interaction studies which may require dose adjustment and/or clinical monitoring include (see Table 2) ciclosporin, sirolimus, tacrolimus, amlodipine, rilpivirine and alprazolam.
Danish: CYP3A-substrater, der er undersøgt i lægemiddelinteraktionsstudier, og som kan nødvendiggøre dosisjustering og/eller klinisk monitorering, omfatter (se tabel 2) ciclosporin, sirolimus, tacrolimus, amlodipin, rilpivirin og alprazolam.
English: Following a 25 mg single dose of 14C-ombitasvir given alone, unchanged parent drug accounted for 8.9% of total radioactivity in human plasma; a total of 13 metabolites were identified in human plasma.
Danish: Efter en enkeltdosis 14C-ombitasvir 25 mg administreret alene stod uomdannet moderstof for 8,9 % af den samlede radioaktivitet i humant plasma; i alt 13 metabolitter blev identificeret i humant plasma.
English: Potential for Viekirax to affect the pharmacokinetics of other medicinal products In vivo drug interaction studies evaluated the net effect of the combination treatment, including ritonavir.
Danish: Viekirax' potentielle indvirkning på andre lægemidlers farmakokinetik Nettovirkningen af kombinationsbehandlingen, inklusive ritonavir, er undersøgt i lægemiddelinteraktionsstudier in vivo.
English: In vitro data indicate that paritaprevir is a substrate for the human hepatic uptake transporters, OATP1B1 and OATP1B3.
Danish: In vitro-data peger på, at paritaprevir er et substrat for de humane hepatiske uptake-transportere OATP1B1 og OATP1B3.
English: The activity of paritaprevir was reduced 96-fold by D168V, and 50- to 219-fold by each of the other D168 substitutions.
Danish: Aktiviteten af paritaprevir blev reduceret med 96 gange af D168V-substitutionen og med 50-219 gange af hver af de andre D168substitutioner.
English: • Check for side effects of Viekirax or other antiviral medicines your doctor has prescribed for you to use with Viekirax (such as “dasabuvir” and “ribavirin”).
Danish: • se, om der er bivirkninger ved Viekirax eller de andre antivirale lægemidler, som lægen har ordineret sammen med Viekirax (f.eks. ”dasabuvir” og ”ribavirin”).
English: The majority of adverse reactions presented in Table 3 were of grade 1 severity in Viekirax and dasabuvir-containing regimens.
Danish: De fleste af bivirkningerne i tabel 3 var af sværhedsgrad 1 i regimer med Viekirax og dasabuvir-holdige regimer.
English: No dose adjustment of Viekirax is required in patients with mild hepatic impairment (Child-Pugh A).
Danish: Det er ikke nødvendigt at justere dosis af Viekirax hos patienter med let nedsat leverfunktion (Child-Pugh A).
English: Paritaprevir is metabolised predominantly by CYP3A4 and to a lesser extent CYP3A5.
Danish: Paritaprevir metaboliseres hovedsagelig af CYP3A4 og i mindre omfang af CYP3A5.
English: Refer to the Summary of Product Characteristics of dasabuvir for its pharmacological properties.
Danish: Se beskrivelsen af dasabuvirs farmakologiske egenskaber i produktresuméet for dasabuvir.
English: The effect on rilpivirine exposures was similar to that observed when rilpivirine was administered in the morning with food with Viekirax + dasabuvir (shown in the table above).
Danish: Indvirkningen på rilpivirin-eksponeringen var af samme størrelsesorden som ved samtidig administration af rilpivirin om morgenen med et måltid og Viekirax med dasabuvir (vist i tabellen ovenfor).
English: HIV ANTIVIRALS: PHARMACOKINETIC ENHANCER Cobicistatcontaining regimens
Danish: HIV-ANTIVIRALE MIDLER: FARMAKOKINETISKE FORSTÆRKERE Cobicistatregimer
English: In Part 1a, SVR12 was achieved by 29/31 (93.5%) subjects on the 12-week arm (95% CI: 79.3%, 98.2%) and by 29/32 (90.6%) subjects on the 24-week arm (95% CI: 75.8% - 96.8%).
Danish: I del 1a blev SVR12 opnået af 29/31 (93,5%) forsøgspersoner i 12 ugers armen (95% KI: 79,3% - 98,2%) og af 29/32 (90,6%) forsøgspersoner i 24 ugers armen (95% KI: 75,8% - 96,8%).
English: Itraconazole Posaconazole
Danish: Itraconazol Posaconazol
English: Viekirax and dasabuvir for 12 or 24 weeks with or without ribavirin ( investigator chosen dose ) for GT1 and GT4 infection
Danish: Behandling: Viekirax og dasabuvir i 12 eller 24 uger med eller uden ribavirin ( investigator valgt dosis) til GT1- og GT4-infektion
English: • apalutamide,enzalutamide
Danish: • apalutamid, enzalutamid
English: Viekirax administered with or without dasabuvir did not affect the exposures of the CYP2D6/CYP1A2 substrate, duloxetine.
Danish: Viekirax administreret med eller uden dasabuvir havde ingen indvirkning på eksponeringen for CYP2D6/CYP1A2-substratet duloxetin.
English: - have liver disease other than hepatitis C; -have a current or previous infection with the hepatitis B virus, since your doctor may want to monitor you more closely.
Danish: Kontakt lægen eller apotekspersonalet, før du tager Viekirax, hvis du: - har en anden leversygdom end hepatitis C; - har eller har haft en infektion med hepatitis B-virus, da din læge måske vil overvåge dig tættere.
English: Ombitasvir was approximately 99.9% bound to human plasma proteins.
Danish: Ombitasvir var ca. 99,9 % bundet til humane plasmaproteiner.
English: Ombitasvir-derived material was minimally transferred through the placenta in pregnant rats.
Danish: Ombitasvir-deriveret materiale passerede kun i minimalt omfang gennem placenta hos drægtige rotter.
English: Viekirax tablets are taken with other antiviral medicines such as dasabuvir and ribavirin.
Danish: Viekirax-tabletterne tages sammen med andre antivirale lægemidler som f.eks. dasabuvir og ribavirin.
English: Primary SVR12 Assessment for Part 2 Subjects with HCV GT1/HIV-1 co-infection in TURQUOISE-I
Danish: Primær SVR12 vurdering for del 2 for forsøgspersoner med samtidig HCV GT1/hiv-1infektion i TURQUOISE I
English: The changes in ombitasvir, paritaprevir, and ritonavir exposures in subjects with mild, moderate and severe renal impairment are not considered to be clinically significant.
Danish: Ændringer i eksponeringen af ombitasvir, paritaprevir og ritonavir hos patienter med let, moderat og svært nedsat nyrefunktion anses ikke for at være klinisk signifikante.
English: NS3 variants V36A/M and R155K and NS5B variants M414T and S556G remained detectable at posttreatment Week 48, whereas NS3 variant D168V and all other NS5B variants were not observed at posttreatment Week 48.
Danish: NS3-varianterne V36A/M og R155K samt NS5B-varianterne M414T og S556G var stadig detekterbare 48 uger efter behandlingen, mens NS3-variant D168V og alle øvrige NS5B-varianter ikke blev observeret 48 uger efter behandlingen.
English: Viekirax and dasabuvir 12 weeks N = 509 n (%)
Danish: Viekirax og dasabuvir 12 uger N = 509 n (%)
English: ANTIPSYCHOTICS
Danish: ANTIPSYKOTIKA
English: In Phase 3 clinical trials, 91.5% of subjects did not require ribavirin dose adjustments during therapy.
Danish: I kliniske fase 3-studier var det ikke nødvendigt at justere ribavirin-dosen under behandlingen hos 91,5 % af forsøgspersonerne.
English: In case a dose of Viekirax is missed, the prescribed dose can be taken within 12 hours.
Danish: Hvis en patient glemmer at tage en dosis Viekirax, kan den ordinerede dosis tages op til 12 timer senere.
English: The safety summary is based on pooled data from phase 2 and 3 clinical trials in subjects who received Viekirax and dasabuvir with or without ribavirin.
Danish: Sikkerhedsprofilen er baseret på samlede data fra kliniske fase 2- og fase 3-studier hos forsøgspersoner, der fik Viekirax og dasabuvir med eller uden ribavirin.
English: Although ALT elevations associated with Viekirax and dasabuvir have been asymptomatic, patients should be instructed to watch for early warning signs of liver inflammation, such as fatigue, weakness, lack of appetite, nausea and vomiting, as well as later signs such as jaundice and discoloured faeces, and to consult a doctor without delay if such symptoms occur.
Danish: Selvom det forhøjede ALAT-niveau i forbindelse med Viekirax og dasabuvir har været asymptomatisk, skal patienterne informeres om, at de skal være opmærksomme på tidlige tegn på leverbetændelse, f.eks. træthed, svaghed, appetitløshed, kvalme og opkastning, samt senere tegn som f.eks. gulsot og misfarvet afføring.
English: Women of childbearing potential / contraception in males and females
Danish: Fertile kvinder/prævention hos mænd og kvinder
English: The highest documented single dose administered to healthy volunteers was 400 mg for paritaprevir (with 100 mg ritonavir), 200 mg for ritonavir (with 100 mg paritaprevir) and 350 mg for ombitasvir.
Danish: Den højeste dokumenterede enkeltdosis administreret til raske forsøgspersoner var 400 mg for paritaprevir (med 100 mg ritonavir), 200 mg for ritonavir (med 100 mg paritaprevir) og 350 mg for ombitasvir.
English: SVR12 for HCV Genotype 4-Infected Subjects with Compensated Cirrhosis Ombitasvir + Paritaprevir + Ritonavir with RBV 12 Weeks
Danish: SVR12 for HCV Genotype 4-smittede forsøgspersoner med kompenseret cirrose Ombitasvir + Paritaprevir + Ritonavir med RBV 12 uger
English: Target
Danish: Mål
English: Paritaprevir -derived material was minimally transferred through the placenta in pregnant rats.
Danish: Paritaprevir-deriveret materiale passerede kun i minimalt omfang gennem placenta hos drægtige rotter.
English: 4-24 mg/16 mg once daily8
Danish: 4-24 mg/16 mg én gang dagligt8
English: Avoid concomitant use of tacrolimus or sirolimus with Viekirax and dasabuvir unless the benefits outweigh the risks.
Danish: Undgå samtidig brug af tacrolimus eller sirolimus med Viekirax og dasabuvir medmindre fordelene opvejer risiciene.
English: • lomitapide
Danish: • lomitapid
English: ANTIHISTAMINES
Danish: ANTIHISTAMINER
English: Nevirapine etravirine
Danish: Nevirapin etravirin
English: Cyclobenzapr ine 5 mg single dose
Danish: Cyclobenzapr in 5 mg enkelt dosis
English: Double variants including combinations of V36LM, F43L, Y56H, Q80K or E357K with R155K or with a D168 substitution reduced the activity of paritaprevir by an additional 2 to 3-fold relative to the single R155K or D168 substitution.
Danish: Dobbeltvarianter, herunder V36LM, F43L, Y56H, Q80K eller E357K kombineret med R155K eller med en D168substitution, reducerede aktiviteten af paritaprevir med yderligere 2-3 gange i forhold til R155K- eller D168-enkeltsubstitutionen.
English: Beginning the day after Viekirax and dasabuvir are initiated; reinitiate tacrolimus at a reduced dose based on tacrolimus blood concentrations.
Danish: Viekirax og dasabuvir behandling er indledt; genstart tacrolimus med reduceret dosis baseret på tacrolimus blodkoncentration.
English: Plasma protein binding is not meaningfully altered in subjects with renal or hepatic impairment.
Danish: Plasmaproteinbindingen ændres ikke nævneværdigt hos patienter med nedsat nyre- eller leverfunktion.
English: The overall safety profile in HCV-infected transplant recipients who were administered Viekirax and dasabuvir and ribavirin (in addition to their immunosuppressant medications) was similar to subjects treated with Viekirax and dasabuvir and ribavirin in phase 3 clinical trials, although some adverse reactions were increased in frequency.
Danish: Den overordnede sikkerhedsprofil hos de HCV-smittede patienter med levertransplantat, der fik Viekirax og dasabuvir med ribavirin (i tillæg til deres immunsupprimerende medicin), var den samme som hos de forsøgspersoner, der fik Viekirax og dasabuvir med ribavirin i kliniske fase 3-studier, selvom visse bivirkninger forekom hyppigere.
English: ↑ losartan ↑ candesartan
Danish: ↑ valsartan ↑ losartan ↑ candesartan
English: Serious and/or life threatening events have been observed with co-administration of Viekirax and dasabuvir with systemic tacrolimus, and a similar risk can be expected with sirolimus and everolimus.
Danish: Ved samtidig administration af Viekirax og dasabuvir med systemisk tacrolimus er alvorlige og/eller livstruende hændelser observeret, og en lignende risiko kan forventes med sirolimus og everolimus.
English: Ritonavir does not inhibit OAT1 and is not expected to inhibit OCT2, OAT3, MATE1 and MATE2K at clinically relevant concentrations.
Danish: Ritonavir hæmmer ikke OAT1 og forventes ikke at hæmme OCT2, OAT3, MATE1 og MATE2K ved klinisk relevante koncentrationer.
English: Concerning genotypespecific virological and clinical activity, see section 5.1.
Danish: 5.1 for genotypespecifik virologisk og klinisk aktivitet.
English: ↓ carbamaze pine 10, 11epoxide ombitasvir
Danish: carbamazepi n-10, 11epoxid ombitasvir
English: • astemizole, terfenadine
Danish: • astemizol, terfenadin
English: The frequency of indirect bilirubin elevations was lower among subjects who did not receive ribavirin.
Danish: Forekomsten af forhøjet ikkekonjugeret bilirubin var lavere hos forsøgspersoner, der ikke fik ribavirin.
English: Medicines you must tell your doctor about before taking Viekirax Medicine or active substance
Danish: Lægemidler, som lægen skal vide, om du tager, før du tager Viekirax Lægemiddel eller aktivt stof
English: − Tablet core: copovidone, tocofersolan, propylene glycol monolaurate, sorbitan monolaurate, colloidal anhydrous silica (E 551), sodium stearyl fumarate.
Danish: − Tabletkerne: copovidon, tocofersolan, propylenglykolmonolaurat, sorbitanmonolaurat, kolloid vandfri silica(E 551), natriumstearylfumarat.
English: 5 subjects required erythropoietin, all of whom initiated ribavirin at the starting dose of 1000 to 1200 mg daily.
Danish: Fem (5) forsøgspersoner havde behov for erytropoietin, og de havde alle fået en startdosis ribavirin på 1.000-1.200 mg pr. dag.
English: Medicinal products that inhibit CYP3A4 and transport proteins Paritaprevir is eliminated via CYP3A4 mediated metabolism and biliary excretion (substrate of the hepatic transporters OATP1B1, P-gp and BCRP).
Danish: Lægemidler, der hæmmer CYP3A4 og transportproteiner Paritaprevir elimineres ved CYP3A4-medieret metabolisering og biliær udskillelse (substrat af de hepatiske transportere OATP1B1, P-gp og BCRP).
English: GIVEN WITH
Danish: GIVET SAMMEN MED
English: Pink, oblong, biconvex, film-coated tablets of dimensions 18.8 mm x 10.0 mm, debossed on one side with ‘AV1'.
Danish: Lyserøde, aflange, bikonvekse filmovertrukne tabletter på 18,8 mm x 10,0 mm præget med "AV1" på den ene side.
English: • Less than 12 hours until your next dose - do not take the missed dose, take your next dose as usual with food.
Danish: • under 12 timer til din næste dosis, så skal du ikke tage den manglende dosis, men vente til den efterfølgende dosis og tage denne sammen med noget mad.
English: THYROID HORMONES
Danish: THYROIDEAHORMONER
English: Co-administration of Viekirax with or without dasabuvir can decrease exposures of medicinal products that are metabolized by CYP2C19 (e.g. lansoprazole, esomeprazole, s-mephenytoin), which may require dose adjustment/clinical monitoring.
Danish: Samtidig administration af Viekirax med eller uden dasabuvir kan reducere eksponeringen for lægemidler, der metaboliseres af CYP2C19 (f.eks. lansoprazol, esomeprazol, s-mephenytoin), hvilket kan gøre dosisjustering/klinisk monitorering nødvendig.
English: ↑ astemizole/terfenadine
Danish: ↑ astemizol/terfenadin
English: Atazanavir can be used in combination with Viekirax and dasabuvir, if administered at the same time.
Danish: Atazanavir kan bruges i kombination med Viekirax og dasabuvir, hvis administration er på samme tid.