FrancophonIA/ELRC3.0 huggingface dataset:
English: 6.5 Nature and contents of the container
Croatian: 6.5 Vrsta i sadržaj spremnika
English: As with all injectable vaccines, appropriate medical treatment and supervision should always be readily available in case of a rare anaphylactic event following the administration of the vaccine.
Croatian: Kao i kod svih injekcijskih cjepiva, odgovarajuće liječenje i medicinski nadzor trebaju uvijek biti lako dostupni u slučaju pojave rijetkog anafilaktičkog događaja nakon primjene cjepiva.
English: ADR frequency is based upon the following scale: Very Common (≥ 1/10); Common (≥ 1/100< 1/10), Uncommon (≥ 1/1,000 - < 1/100), Rare (≥ 1/10,000 - < 1/1,000), Very Rare (< 1/10,000)
Croatian: Učestalost nuspojava temelji se na sljedećoj ljestvici: Vrlo često (≥1/10); Često (≥1/100 i <1/10), Manje često (≥1/1000 i <1/100), Rijetko (≥1/10 000 i <1/1000), Vrlo rijetko (<1/10 000)
English: The other ingredients are: trometamol, sodium chloride, water for injections, polysorbate 80.
Croatian: Drugi sastojci su: trometamol, natrijev klorid, voda za injekcije, polisorbat 80.
English: There were fewer reactions after the second dose of the vaccine compared with the first dose.
Croatian: Nakon druge doze cjepiva bilo je manje reakcija nego nakon prve doze.
English: Frequency 9 - 17 years 3 - 8 years 6 - 35 months
Croatian: Učestalost 9 - 17 godina 3 - 8 godina 6 - 35 mjeseci
English: Influenza-like illness
Croatian: Bolest slična influenci
English: • Adverse events to be prioritised for reporting, i.e. fatal and life-threatening adverse reactions, unexpected severe adverse reactions, adverse events of special interest
Croatian: • Štetni događaji koje prvenstveno treba prijaviti, tj. smrtonosne i po život opasne nuspojave, neočekivane ozbiljne nuspojave, štetni događaji od posebnog interesa
English: Pharmacotherapeutic group: Influenza vaccines, ATC Code J07BB01
Croatian: Farmakoterapijska skupina: Cjepiva protiv gripe, ATK oznaka J07BB01
English: There were no reported vaccine failures in either of these paediatric age groups.
Croatian: Nijedan slučaj neuspjelog cijepljenja nije prijavljen ni u jednoj od tih pedijatrijskih dobnih skupina.
English: One dose of 0.5 ml at an elected date.
Croatian: Jedna doza od 0,5 ml na odabrani datum.
English: Detailed information on this medicine is available on the European Medicines Agency (EMA) web site: http://www.ema.europa.eu/.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na web stranici Europske agencije za lijekove (EMA): http://www.ema.europa.eu.
English: Data from pregnant women vaccinated with different inactivated non-adjuvanted seasonal vaccines do not suggest malformations or fetal or neonatal toxicity.
Croatian: Podaci dobiveni od trudnica cijepljenih različitim inaktiviranim neadjuventiranim sezonskim cjepivima ne upućuju na malformacije ili fetalnu ili neonatalnu toksičnost.
English: Trivalent seasonal influenza vaccines
Croatian: Trivalentna cjepiva protiv sezonske gripe
English: Therefore, healthcare providers need to assess the benefits and potential risks of administering the vaccine in individuals with thrombocytopenia or any bleeding disorder that would contraindicate intramuscular injection unless the potential benefit outweighs the risk of bleedings.
Croatian: Stoga, pružatelji zdravstvene skrbi trebaju ocijeniti koristi i moguće rizike primjene cjepiva u pojedinaca s trombocitopenijom ili nekim drugim poremećajem krvarenja koji bi kontraindicirao intramuskularnu injekciju, osim ako je moguća korist značajnija od rizika od krvarenja.
English: How to store Celvapan
Croatian: Kako čuvati Celvapan
English: Following influenza vaccination, false positive serology test results may be obtained by the ELISA method for antibody to human immunodeficiency virus-1 (HIV-1), hepatitis C virus, and especially, HTLV-1.
Croatian: Nakon cijepljenja protiv influence mogu se dobiti lažno pozitivni rezultati seroloških testiranja metodom ELISA na protutijelo protiv virusa humane imunodeficijencije -1 (HIV-1), hepatitisa C i posebno virusa HTLV-1.
English: Allergic reactions, including anaphylactic reactions leading to a dangerous decrease in blood pressure which, if untreated, may lead to shock.
Croatian: Alergijske reakcije, uključujući anafilaktičke reakcije koje dovode do opasnog sniženja krvnog tlaka, što, ako se ne liječi, može dovesti do šoka.
English: Day 361
Croatian: 361. dan
English: The following information is intended for medical or health care professionals only: Prior to administration, the vaccine should be allowed to reach room temperature and the vial should
Croatian: Sljedeće informacije namijenjene su samo liječnicima ili zdravstvenim djelatnicima: Prije primjene cjepivo treba ostaviti da dosegne sobnu temperaturu, a bočicu treba dobro protresti.
English: The vaccine will be injected into a muscle (usually in the upper arm).
Croatian: Cjepivo će se injicirati u mišić (najčešće u nadlakticu).
English: They may also happen with Celvapan.
Croatian: One se mogu pojaviti i nakon Celvapana.
English: In the clinical studies, most side effects were mild in nature and short term.
Croatian: U kliničkim je ispitivanjima većina nuspojava bila blage naravi i kratkotrajna.
English: Children and adolescents aged 3 to 17 years One dose of 0.5 ml at an elected date.
Croatian: Djeca i adolescenti u dobi od 3 do 17 godina Jedna doza od 0,5 ml na odabrani datum.
English: • Side effects observed during post-marketing surveillance
Croatian: • Nuspojave zabilježene tijekom postmarketinškog praćenja
English: Immune response against A/California/07/2009(H1N1)v
Croatian: Imunološki odgovor na A/California/07/2009(H1N1)v
English: Your doctors know that this might happen and will have emergency treatment ready to use.
Croatian: Liječnici znaju da se to može dogoditi pa imaju spremno hitno liječenje.
English: • generalized skin reactions including urticaria (hives)
Croatian: • generalizirane kožne reakcije uključujući urtikariju (koprivnjaču)
English: Such alterations in liver function have not been seen to date in human clinical studies.
Croatian: Takve promjene u funkciji jetre do danas nisu zabilježene u kliničkim ispitivanjima na ljudima.
English: Adults aged 18 years and older
Croatian: Odrasli u dobi od 18 godina i stariji
English: Any unused vaccine or waste material should be disposed of in accordance with local requirements.
Croatian: Neiskorišteno cjepivo ili otpadni materijal valja zbrinuti sukladno lokalnim propisima.
English: Children aged less than 6 months Vaccination is not currently recommended in this age group.
Croatian: Djeca u dobi od manje od 6 mjeseci: Trenutno nije preporučeno cijepljenje za ovu dobnu skupinu.
English: Anaphylactic reaction*, Hypersensitivity*
Croatian: Anafilaktička reakcija*, preosjetljivost*
English: See section 6.5 for the number of doses per vial.
Croatian: Vidjeti dio 6.5 za broj doza po bočici.
English: For storage conditions after first opening of the medicinal product, see section 6.3.
Croatian: Uvjete čuvanja nakon prvog otvaranja lijeka vidjeti u dijelu 6.3.
English: The use of Celvapan may be considered during pregnancy if this is thought to be necessary, taking into
Croatian: Primjena cjepiva Celvapan može se razmatrati tijekom trudnoće ako se to smatra potrebnim, no pritom je potrebno uzeti u obzir službene preporuke.
English: The immunological response may be diminished if the patient is undergoing immunosuppressant treatment.
Croatian: Imunološki odgovor može biti slabiji ako pacijent prima imunosupresivnu terapiju.
English: It should be noted that the adverse reactions may be intensified.
Croatian: Potrebno je napomenuti da može doći do intenziviranja nuspojava.
English: In accordance with Article 114 Directive 2001/83/EC, the official batch release will be undertaken by a state laboratory or a laboratory designated for that purpose.
Croatian: • Službeno puštanje serije lijeka u promet Sukladno članku 114 Direktive 2001/83/EC, službeno puštanje serije lijeka u promet preuzet će državni laboratoriji ili laboratorij određen za tu svrhu.
English: If you have any further questions, ask your doctor or nurse.
Croatian: Ako imate dodatnih pitanja, obratite se svom liječniku ili medicinskoj sestri.
English: Each vaccine dose of 0.5 ml is withdrawn into a syringe for injection.
Croatian: Svaka doza cjepiva od 0,5 ml povlači se u štrcaljku za injekciju.
English: Alterations in calcium metabolism have not been examined in human clinical studies.
Croatian: Promjene metabolizma kalcija nisu proučavane u kliničkim ispitivanjima na ljudima.
English: Celvapan may be used in lactating women.
Croatian: Celvapan se može koristiti kod žena u laktaciji.
English: Younger children 6 months to 9 years received Celvapan, while older children from 9 to 18 years of age received an adjuvanted split pandemic vaccine.
Croatian: Manja djeca u dobi od 6 mjeseci do 9 godina primala su Celvapan, dok su starija djeca u dobi od 9 do 18 godina primala adjuvantirano fragmentirano pandemijsko cjepivo.
English: The vaccine may be used during breast-feeding.
Croatian: Cjepivo se može koristiti tijekom dojenja.
English: 6 to 11 months
Croatian: 6 do 11 mjeseci
English: Pain in arms and or legs (in the majority of cases reported as pain in the vaccination arm)
Croatian: Bol u rukama i/ili nogama (u većini slučajeva prijavljeno kao bol u ruci u koju je
English: 2nd Dose
Croatian: 2. doza
English: The dose recommendations take into account available data from clinical studies in healthy subjects who received two doses of Celvapan (H1N1)v.
Croatian: Preporuke doziranja uzimaju u obzir dostupne podatke iz kliničkih ispitivanja u zdravih ispitanika koji su primili dvije doze cjepiva Celvapan (H1N1)v.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system
Croatian: Od zdravstvenih djelatnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prije nuspojava navedenog u
English: 3 to 8 years
Croatian: 3 do 8 godina
English: • The MAH shall agree with Member States to measures facilitating the identification and traceability of the A/(H1N1)v vaccine administered to each patient, in order to minimise medication errors and aid patients and health care professionals to report adverse reactions.
Croatian: • Nositelj odobrenja će s državama članicama dogovoriti mjere koje omogućavaju identifikaciju i sljedivost cjepiva A/(H1N1)v danog svakom pacijentu radi smanjenja na najmanju moguću mjeru medikacijskih pogrešaka i pomaganja pacijentima i zdravstvenim djelatnicima s prijavom nuspojava.
English: The vaccine is a clear to opalescent, translucent suspension.
Croatian: Cjepivo je bistra do opalescentna, prozirna suspenzija.
English: Shake before use.
Croatian: Protresti prije primjene.
English: • The MAH shall agree with Member States on the provision of a targeted communication to health care professionals which should address the following:
Croatian: • Nositelj odobrenja će s državama članicama dogovoriti pružanje ciljanih priopćenja zdravstvenim djelatnicima koja bi trebale navoditi sljedeće:
English: Preferred MedDRA Term
Croatian: Preporučeni MedDRA naziv
English: Side effects from clinical studies in adults and older people
Croatian: Nuspojave iz kliničkih ispitivanja u odraslih i starijih osoba
English: Additionally, in the case of the 9 to 17 year olds pain at the injection site was very common.
Croatian: Osim toga, kod djece u dobi od 9 do 17 godina, bila je vrlo česta bol na mjestu injekcije.
English: After first opening, the vial is to be used within a maximum of 3 hours.
Croatian: Nakon prvog otvaranja, bočica se mora iskoristiti u roku od najviše 3 sata.
English: There are no safety, immunogenicity or efficacy data to support interchangeability of Celvapan with other (H1N1)v vaccines.
Croatian: Ne postoje podaci o sigurnosti, imunogenosti ili djelotvornosti koji bi poduprli međusobnu zamjenjivost Celvapana i drugih cjepiva protiv virusa (H1N1)v.
English: When Celvapan is given for the first dose, it is recommended that Celvapan (and not another vaccine against (H1N1)v) be given for the complete vaccination course.
Croatian: Kada se daje prva doza cjepiva Celvapan, preporučuje se davanje Celvapana (a ne drugog cjepiva protiv (H1N1)v) tijekom cijelog ciklusa cijepljenja.
English: Animal reproductive toxicology studies do not indicate harmful effects in regard to female fertility, embryo-foetal and pre- and post-natal toxicity.
Croatian: Ispitivanja reproduktivne toksičnosti na životinjama ne ukazuju na štetan učinak na plodnost ženki, embrio-fetalnu i prenatalnu i postnatalnu toksičnost.
English: Pandemic vaccine effectiveness against the medically-attended influenza like illness (ILI) with laboratory-confirmation as A(H1N1)v, was assessed for the vaccination campaign in Jersey 2009/2010 in a case control study (test-negative design).
Croatian: Učinkovitost pandemijskog cjepiva protiv medicinski liječene bolesti slične gripi koja je laboratorijski potvrđena kao A(H1N1)v procijenjena je za kampanju cijepljenja u Jerseyu 2009./2010. u istraživanju slučaja s kontrolom (test-negativan dizajn).
English: Crude vaccine effectiveness of one dose of pandemic vaccine among children was 100% (95%
Croatian: Neobrađena učinkovitost cjepiva jedne doze pandemijskog cjepiva među djecom bila je 100% (95% CI: 70-100%).
English: Non-Clinical data obtained with Celvapan containing a H5N1 vaccine strain demonstrated alterations in liver enzymes and calcium levels in repeat dose toxicity studies in rats.
Croatian: Neklinički podaci dobiveni s Celvapanom koji sadrži soj cjepiva H5N1 pokazali su promjene u enzimima jetre i razinama kalcija u ispitivanjima toksičnosti ponovljene doze na štakorima.
English: 12 to 35 months
Croatian: 12 do 35 mjeseci
English: Seronegative subjects at baseline (≤ 4mm2)
Croatian: Ispitanici seronegativni na početku (≤ 4mm2)
English: The frequency of these adverse reactions is not known.
Croatian: Učestalost ovih nuspojava nije poznata.
English: • you have a bleeding condition or a bleeding problem or you bruise easily.
Croatian: • ako imate problema s krvarenjem ili lako dobijete modrice.
English: Celvapan should under no circumstances be administered intravascularly.
Croatian: Celvapan se ni u kojim okolnostima ne smije primijeniti intravaskularno.
English: Hypersensitivity reactions, including anaphylaxis, have been reported following CELVAPAN vaccination (see section 4.8).
Croatian: Reakcije preosjetljivosti, uključujući anafilaksu, zabilježene su nakon primjene cjepiva CELVAPAN (vidjeti dio 4.8).
English: Dispose of in accordance with local requirements.
Croatian: Zbrinuti sukladno lokalnim propisima.
English: Allergic reactions may occur following vaccination, in rare cases leading to shock.
Croatian: Nakon cijepljenja može doći do alergijskih reakcija koje u rijetkim slučajevima mogu dovesti do šoka.
English: Neurological disorders, such as encephalomyelitis, neuritis and Guillain Barré syndrome.
Croatian: Neurološki poremećaji kao što su encefalomijelitis, neuritis i Guillain Barréov sindrom.
English: • Fever, shivering, generally feeling unwell
Croatian: • Vrućica, tresavica, općenito loše osjećanje
English: It is recommended that subjects who receive a first dose of Celvapan, complete the vaccination course with Celvapan (see section 4.4).
Croatian: Preporučuje se da ispitanici koji prime prvu dozu cjepiva Celvapan, završe ciklus cijepljenja s cjepivom Celvapan (vidjeti dio 4.4).
English: *Such reactions have been manifested by respiratory distress, hypotension, tachycardia, tachypnea, cyanosis, pyrexia, flushing, angioedema, and urticaria Musculoskeletal and connective tissue disorders:
Croatian: *Takve su se reakcije manifestirale kao respiratorni distres, hipotenzija, tahikardija, tahipneja, cijanoza, pireksija, crvenilo, angioedem i urtikarija
English: Prophylaxis of influenza caused by A(H1N1)v 2009 virus (See section 4.4).
Croatian: Profilaksa influence prouzročene virusom A(H1N1)v 2009. (Vidjeti dio 4.4).
English: In a study with a similar influenza vaccine (containing a H5N1 vaccine strain) that included healthy adults and older people, subjects with a weakened immune system and patients with long-term conditions, the safety profile was similar to that in healthy adults.
Croatian: U ispitivanju sa sličnim cjepivom protiv influence (koje sadrži soj cjepiva H5N1) koje je uključivalo zdrave odrasle i starije osobe, ispitanike s oslabljenim imunološkim sustavom i pacijente s dugotrajnim stanjima, sigurnosni profil bio je sličan onome zdravih odraslih osoba.
English: In children aged 6 to 35 months disturbed sleep and fever were very common, and decreased appetite, restlessness, irritability, crying and drowsiness were common.
Croatian: U djece u dobi od 6 do 35 mjeseci vrlo često je zabilježeno poremećeno spavanje i vrućica, a često smanjen apetit, nemir, razdražljivost, plačljivost i omamljenost.
English: There are no data with Celvapan using the subcutaneous route.
Croatian: Nema podataka o Celvapanu primijenjenom supkutanim putem.
English: PSYCHIATRIC DISORDERS
Croatian: PSIHIJATRIJSKI POREMEĆAJI
English: From clinical studies limited immunogenicity and safety data are available for Celvapan (H1N1)v in healthy adult and older subjects and in children (see section 4.4, 4.8, and 5.1).
Croatian: Dostupni su ograničeni podaci o imunogenosti i sigurnosti primjene cjepiva Celvapan (H1N1)v iz kliničkih ispitivanja u zdravih odraslih i starijih ispitanika i djece (vidjeti dio 4.4, 4.8, i 5.1).
English: One pack of Celvapan contains 20 multidose vials of 5 ml suspension for injection for 10 doses.
Croatian: Jedno pakovanje Celvapana sadrži 20 višedoznih bočica s 5 ml suspenzije za injekciju za 10 doza.
English: However, if co-administration with another vaccine is considered, immunisation should be carried out on separate limbs.
Croatian: Međutim, ako se razmatra istovremena primjena s drugim cjepivom, cijepljenje se treba provesti na različitim udovima.
English: The safety profile in healthy subjects > 60 years of age, in immune-compromised subjects and patients with chronic disease conditions is similar to the safety profile in healthy subjects.
Croatian: Sigurnosni profil kod zdravih ispitanika u dobi od > 60 godina, kod imunokompromitiranih ispitanika i kod pacijenata s kroničnim bolestima sličan je sigurnosnom profilu kod zdravih ispitanika.
English: • The minimal data elements to be transmitted in individual case safety reports in order to facilitate the evaluation and the identification of the vaccine administered to each subject, including the invented name, the vaccine manufacturer and the
Croatian: • Minimalne pojedinosti koje treba prijaviti u pojedinačnim sigurnosnim prikazima slučaja radi omogućavanja procjene i identifikacije cjepiva danog svakom pacijentu, uključujući zaštićeno ime, proizvođača cjepiva i serijski broj.
English: If any of these side effects occur, please tell your doctor or nurse immediately.
Croatian: Ako se pojavi bilo koja od navedenih nuspojava, molimo odmah obavijestite liječnika ili medicinsku
English: If you are not sure, talk to your doctor or nurse before having this vaccine.
Croatian: Ako niste sigurni, razgovarajte sa svojim liječnikom ili medicinskom sestrom prije primanja
English: A second dose of vaccine should be given after an interval of at least three weeks.
Croatian: Drugu dozu cjepiva treba dati s razmakom od najmanje tri tjedna.
English: The vaccine should be allowed to reach room temperature before use.
Croatian: Prije uporabe cjepivo treba pustiti da dosegne sobnu temperaturu.
English: Neuralgia, paraesthesia, transient thrombocytopenia.
Croatian: Neuralgija, parestezija, prolazna trombocitopenija.
English: Specifically, headache, vertigo (spinning feeling), cough, feeling sick, vomiting, diarrhoea, pain in the arms or legs and tiredness were observed commonly in children and adolescents.
Croatian: Točnije, glavobolja, vrtoglavica (osjećaj vrtnje), kašalj, mučnina, povraćanje, proljev, bol u rukama ili nogama ili umor primijećeni su često kod
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Celvapan suspension for injection
Croatian: NAZIV LIJEKA I PUT(EVI) PRIMJENE LIJEKA Celvapan suspenzija za injekciju
English: Vaccination is not currently recommended in this age group.
Croatian: Trenutno nije preporučeno cijepljenje za ovu dobnu skupinu.
English: Check with your doctor or nurse before you are given Celvapan if
Croatian: Obratite se svom liječniku ili medicinskoj sestri prije nego što primite Celvapan
English: Clinical studies in which a version of Celvapan containing HA derived from A/Vietnam/1203/2004 (H5N1) was administered at day 0 and at day 21 provide:
Croatian: Klinička ispitivanja u kojima je verzija Celvapana koja sadrži HA dobivena iz soja A/Vietnam/1203/2004 (H5N1) primijenjena 0. dan i 21. dan pružaju:
English: A dose (0.5 ml) of the vaccine will be given.
Croatian: Daje se jedna doza (0,5 ml) cjepiva.
English: • The MAH shall agree with Member States on mechanisms allowing patients and health care professionals to have continuous access to updated information regarding Celvapan.
Croatian: • Nositelj odobrenja će s državama članicama dogovoriti mehanizme koji pacijentima i zdravstvenim djelatnicima omogućavaju neprekidan pristup aktualiziranim informacijama
English: Uncommon:
Croatian: Rijetko:
English: One pack of 20 multidose vials (type I glass) of 5 ml suspension (10 x 0.5 ml doses) with a stopper (bromobutyl rubber).
Croatian: Jedno pakovanje od 20 višedoznih bočica (staklo tipa I.) s 5 ml suspenzije (10 doza x 0,5 ml) s čepom (bromobutilna guma).
English: • vasculitis (inflammation of blood vessels which can cause skin rashes, joint pain and kidney
Croatian: • vaskulitis (upala krvnih žila koja može uzrokovati kožne osipe, bol u zglobovima
English: • Clinical trials with a version of Celvapan containing a H5N1 vaccine strain
Croatian: • Klinička ispitivanja s verzijom Celvapana koja sadrži soj cjepiva H5N1
English: Pain in extremity (in the majority of cases reported as pain in the injection site arm) General disorders and administration site conditions:
Croatian: Bol u udovima (u većini slučajeva prijavljeno kao bol u ruci u koju je primijenjena injekcija) Opći poremećaji i reakcije na mjestu primjene:
English: Seronegative subjects at baseline (≤ 4mm 21 Days After nd
Croatian: Ispitanici seronegativni na početku (≤ 4mm 21 dan kasnije
English: An updated RMP should be submitted: • At the request of the European Medicines Agency;
Croatian: • Na zahtjev Europske agencije za lijekove;
English: (A/Vietnam/1203/2004 and A/Indonesia/05/2005) do not indicate direct or indirect harmful effects with respect to female fertility, pregnancy, embryonal/foetal development, parturition or post-natal
Croatian: Ispitivanja reproduktivne i razvojne toksičnosti na životinjama cjepivima soja H5N1 (A/Vietnam/1203/2004 i A/Indonesia/05/2005) ne ukazuju na izravan ili neizravan štetan učinak na plodnost ženki, trudnoću, embrionalni/fetalni razvoj, porod ili postnatalni
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING
Croatian: UVJETI ILI OGRANIČENJA VEZANI UZ OPSKRBU I PRIMJENU C. OSTALI UVJETI I ZAHTJEVI ODOBRENJA ZA STAVLJANJE LIJEKA
English: Immunisation should be carried out by intramuscular injection preferably into the deltoid muscle or anterolateral thigh, depending on the muscle mass.
Croatian: Cijepljenje treba provesti injekcijom u mišić, najbolje u deltoidni mišić ili anterolateralni dio bedra,
English: Antibody response in patients with endogenous or iatrogenic immunosuppression may be insufficient.
Croatian: Reakcija stvaranja protutijela u pacijenata s endogenom ili jatrogenom imunosupresijom može biti
English: Seroprotection / Seroneutralization rate*
Croatian: Serozaštita / stopa seroneutralizacije*