FrancophonIA/ELRC3.0 huggingface dataset:
English: Sleep attacks/sudden onset of sleep, paranoia, sexual desire disorders a
Croatian: napadi spavanja/iznenad ne epizode spavanja, paranoja, poremećaji spolne željea
English: Description of selected adverse reactions
Croatian: Opis izdvojenih nuspojava
English: BOX OF 28 PATCHES -TREATMENT INITIATION PACK - 4 WEEK TREATMENT SCHEDULE
Croatian: TERAPIJE - RASPORED LIJEČENJA TIJEKOM 4 TJEDNA
English: In a multicenter, double-blind, randomized, 2-way, crossover study in 52 outpatients, the skin adhesion of the improved room temperature patch formulation was compared to the cold storage formulation, using the 8 mg/24 h rotigotine patch.
Croatian: U multicentričnom, dvostruko slijepom, randomiziranom, dvosmjernom ukriženom ispitivanju kod 52 ambulantna bolesnika uspoređivano je kako na kožu prianja poboljšana formulacija flastera koja se čuva na sobnoj temperaturi u odnosu na formulaciju flastera koja se čuva na hladnom mjestu.
English: • Hold the other half of the rigid release liner.
Croatian: • Primite drugu stranu krutog zaštitnog sloja.
English: OUTER LABEL (WITH BLUE BOX) BOX OF 84 PATCHES CONTAINING 3 BOXES OF 28 PATCHES
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU SAMO VIŠESTRUKA PAKIRANJA VANJSKA OZNAKA (S PLAVIM OKVIROM) KUTIJA S 84 FLASTERA KOJA SADRŽI 3 KUTIJE S 28 FLASTERA
English: Irritability
Croatian: iritabilnost
English: Boxes containing 7, 28, 30 or 84 (multipack containing 3 packs of 28) patches, which are individually sealed in sachets.
Croatian: Kutija koja sadrži 7, 28, 30 ili 84 (višestruko pakiranje koje sadrži 3 pakiranja od 28) flastera zasebno pakiranih u vrećice.
English: Use and handling
Croatian: Primjena i rukovanje
English: The following table covers adverse drug reactions from the pooled studies mentioned above in patients with Restless Legs Syndrome and from post-marketing experience.
Croatian: Sljedeća tablica prikazuje nuspojave zabilježene u udruženim, prethodno spomenutim ispitivanjima u bolesnika sa sindromom nemirnih nogu kao i nuspojave koje su se pojavile nakon stavljanja lijeka u promet.
English: Polyester film, siliconized, aluminized, colour coated with a pigment (titanium dioxide (E171), pigment yellow 95, pigment red 166) layer and imprinted (pigment red 144, pigment yellow 95, pigment black 7).
Croatian: Poliesterski film, silikonizirani, aluminizirani, obložen slojem boje (titanijev dioksid (E171), žuta boja 95, crvena boja 166) i s otisnutim natpisom (crvena boja 144, žuta boja 95, crna boja 7).
English: 6.6 Special precaution for disposal
Croatian: 6.6 Posebne mjere za zbrinjavanje
English: • feeling dizzy when standing up because of a fall in blood pressure
Croatian: • osjećaj omaglice pri ustajanju zbog pada krvnog tlaka
English: Patients taking levodopa - advanced stage of Parkinson's disease
Croatian: Bolesnici koji uzimaju levodopu - uznapredovala faza Parkinsonove bolesti
English: This is because rotigotine may pass into your breast milk and affect your baby.
Croatian: Leganto jer se rotigotin izlučuje u majčino mlijeko i može utjecati na dijete, a vjerojatno će i smanjiti količinu majčinog mlijeka koje se izlučuje.
English: Improvements in the mean PDSS-2 total score were 5.9 (rotigotine, baseline 19.3) and 1.9 points (placebo, baseline 20.5).
Croatian: Poboljšanje u ukupnoj prosječnoj ocjeni prema PDSS-2 ljestvici bila je 5,9 (rotigotin, početno 19,3), i 1,9 bodova(placebo, početno 20,5).
English: The box contains 7, 28, 30 or 84 (multipack containing 3 packs of 28) transdermal patches, individually sealed in sachets.
Croatian: Kutija sadrži 7, 28, 30 ili 84 (višestruko pakiranje koje sadrži 3 pakiranja od 28) transdermalnih flastera, zasebno pakiranih u vrećice.
English: • From the second week, your daily dose may be increased by 1 mg each week until you get to the right maintenance dose for you.
Croatian: • Od drugog se tjedna dnevna doza može povećavati za 1 mg tjedno, dok se ne postigne odgovarajuća doza održavanja za Vas.
English: How to store Leganto
Croatian: Kako čuvati Leganto
English: Rotigotine was not teratogenic in all three species, but was embryotoxic in rats and mice at materno-toxic doses.
Croatian: Teratogenost rotigotina nije uočena ni u jednoj od tri ispitivane vrste, ali je uočena embriotoksičnost u štakora i miševa u toksičnim dozama za majku.
English: Tell your doctor if you notice any changes in behaviour, thinking or both that are listed above.
Croatian: Obavijestite svog liječnika ako primijetite bilo koju od navedenih promjena u ponašanju i/ili razmišljanju ili oboje.
English: On the first day of treatment, start with Leganto 2 mg (package marked “Week 1”), and use one Leganto 2 mg transdermal patch daily.
Croatian: Prvi dan liječenja započnite s Leganto 2 mg (pakiranje označeno „Tjedan 1“), i koristite jedan
English: For most patients with advanced-stage Parkinson's disease the right dose is reached within 3 to 7 weeks, at doses of 8 mg per day up to a maximum dose of 16 mg per day.
Croatian: U većine bolesnika s uznapredovalom fazom Parkinsonove bolesti odgovarajuća doza postiže se za 3 do 7 tjedana, dozama od 8 mg na dan do najveće doze od 16 mg na dan.
English: The majority of application site reactions were mild or moderate in intensity, limited to the application areas and resulted in discontinuation of treatment with Leganto in only 4.3% of all subjects receiving Leganto.
Croatian: Većina reakcija na mjestu primjene bila je blagog ili umjerenog intenziteta, ograničena na područja primjene, a samo je 4,3% ispitanika koji su primali Leganto zbog njih prekinulo liječenje Legantom.
English: In the double-blind study SP515, 201 patients received rotigotine, 200 received pramipexole and 100 patients received placebo.
Croatian: U dvostruko-slijepom ispitivanju SP515, 201 bolesnik primao je rotigotin, 200 je primalo pramipeksol i 100 bolesnika je primalo placebo.
English: • Stick the new patch on a different area of the skin each day.
Croatian: • Nalijepite novi flaster svaki dan na drugo mjesto na koži.
English: Treatment of Parkinson's disease
Croatian: Liječenje Parkinsonove bolesti
English: • fainting, feeling dizzy when standing up because of fall in blood pressure
Croatian: • gubitak svijesti, omaglica pri ustajanju zbog pada krvnog tlaka
English: Week 1.
Croatian: Tjedan 1.
English: If your doctor says you should stop Leganto, the daily dose should be lowered gradually:
Croatian: Ako Vam liječnik kaže da trebate prestati koristiti Leganto, dnevnu dozu treba postupno smanjivati:
English: For most patients with early stage Parkinson's disease, the right dose is reached within 3 or 4 weeks, at doses of 6 mg per day or 8 mg per day respectively.
Croatian: U većine bolesnika s ranom fazom Parkinsonove bolesti odgovarajuća doza postiže se za 3 ili 4 tjedna, dozama od 6 mg na dan odnosno 8 mg na dan.
English: • Backing layer: Polyester film, siliconized, aluminized, colour coated with a pigment (titanium dioxide (E171), pigment yellow 95, pigment red 166) layer and imprinted (pigment red 144, pigment yellow 95, pigment black 7).
Croatian: • Potporni sloj: silikonizirani, aluminizirani poliesterski film, obložen slojem boje (titanijev dioksid (E171), žuta boja 95, crvena boja 166) i s otisnutim natpisom (crvena boja 144, žuta boja 95, crna boja 7).
English: System/organ classes acc. to MedDRA
Croatian: Klasifikacija organskih sustava prema MedDRA-i
English: • If the patch has irritated your skin, keep that area protected from direct sunlight.
Croatian: • Ako je flaster nadražio kožu, držite to područje zaštićeno od izravne sunčeve svjetlosti jer mogu nastati promjene u boji kože.
English: The daily dose should be reduced in steps of 1 mg/24 h with a dose reduction preferably every other day, until complete withdrawal of Leganto (see section 4.4).
Croatian: Dnevnu dozu treba postupno smanjivati za 1 mg/24 h, po mogućnosti svaki drugi dan, do potpunog prekida primjene Leganta (vidjeti dio 4.4).
English: Week 1
Croatian: Tjedan 1
English: • agitation
Croatian: • uznemirenost
English: How to use Leganto
Croatian: Kako primjenjivati Leganto
English: • redness, increased sweating, itching
Croatian: • crvenilo, pojačano znojenje, svrbež
English: The mean improvement in the UPDRS score (Parts II + III) was 6.83 points (baseline 33.2 points) in the rotigotine arm, 10.78 points in the ropinirole arm (baseline 32.2 points) and 2.33 points in the placebo arm (baseline 31.3 points).
Croatian: Prosječno poboljšanje ocjene prema UPDRS ljestvici (dijelovi II + III) u rotigotin-skupini bilo je 6,83 boda (početno 33,2), 10,78 bodova u ropinirol skupini (početno 32,2) i 2,33 boda u placebo skupini (početno 31,3).
English: The changes from baseline in the International RLS Rating Scale (IRLS) and CGI-item 1 (severity of illness) were primary efficacy parameters.
Croatian: Primarni parametri djelotvornosti bili su promjene od ishodišne vrijednosti na međunarodnoj ljestvici sindroma nemirnih nogu (International RLS Rating Scale-IRLS) i opće ocjene kliničkog stanja CGI -1 (težina bolesti).
English: • disorientation
Croatian: • dezorijentaciju
English: Leganto may cause other behaviours and abnormal thinking.
Croatian: Leganto može uzrokovati i druge promjene u ponašanju i razmišljanju, koje mogu uključivati:
English: Each patch of 15 cm contains 6.75 mg of rotigotine.
Croatian: Jedan flaster površine 15 cm2 sadrži 6,75 mg rotigotina.
English: The daily dose should be reduced in steps of 2 mg/24 h with a dose reduction preferably every other day, until complete withdrawal of Leganto (see section 4.4).
Croatian: Dnevnu dozu treba postupno smanjivati za 2 mg/24 h, po mogućnosti svaki drugi dan, do potpunog prekida primjene Leganta (vidjeti dio 4.4).
English: Peripheral oedema has been observed in clinical trials conducted in patients with RLS.
Croatian: Periferni je edem bio primjećen u kliničkim ispitivanjima provedenim u bolesnika sa sindromom nemirnih nogu.
English: These events have also been observed during treatment with rotigotine, but the incidence was similar to that observed in placebo-treated patients.
Croatian: Te su pojave također zabilježene i tijekom liječenja rotigotinom, ali incidencija je bila slična onoj zabilježenoj u bolesnika koji su primjenjivali placebo.
English: Based on the analysis of pooled placebo-controlled clinical trials comprising a total of 748 Legantoand 214 placebo-treated patients, 65.5% of the patients on Leganto and 33.2% of patients on placebo reported at least one adverse reaction.
Croatian: Analizom objedinjenih podataka placebom kontroliranih kliničkih ispitivanja u kojima je sudjelovalo ukupno 748 bolesnika koji su liječeni Legantom te 214 bolesnika koji su primali placebo, najmanje jedna nuspojava zabilježena je u 65,5% bolesnika liječenih Legantom i u 33,2% bolesnika na placebu.
English: Weight decreased e, hepatic enzyme increased e
Croatian: smanjenje tjelesne težinee, povećanje vrijednosti jetrenih enzimae
English: If you think that too much heat has been applied, contact your doctor or pharmacist.
Croatian: Ako smatrate da je na flaster djelovala previsoka temperatura, obratite se svom liječniku ili ljekarniku.
English: Dose reduction/tapered discontinuation should be considered if such symptoms develop.
Croatian: Ako se razviju takvi simptomi moraju se razmotriti smanjenje doze/postupni prekid liječenja.
English: This is because the effects of rotigotine on pregnancy and the unborn baby are not known.
Croatian: Nemojte uzimati Leganto ako ste trudni jer nisu poznati učinci rotigotina na trudnoću i nerođeno dijete.
English: Vision blurred, visual impairment, photopsia
Croatian: Poremećaji oka zamagljen vide, oštećenje vidae, fotopsijae
English: Then, the patch is fold back and the second part of the release liner is removed.
Croatian: Zatim se flaster odigne te se odstrani druga polovica zaštitnog sloja.
English: hallucination, hallucination visual, hallucination auditory, illusion), insomnia, sleep disorder, nightmare, abnormal dreams, impulsecontrol disorders a,d
Croatian: (uključujući halucinacije, vizualne i/ili slušne halucinacije, iluzije), poremećaj spavanja, noćne more, abnormalni snovi, poremećaji kontrole nagonaa,d
English: For most patients an effective dose is reached within 3 to 7 weeks at doses of 8 mg/24 h up to a maximum dose of 16 mg/24 h.
Croatian: U većine bolesnika učinkovita doza postiže se za 3 do 7 tjedana dozom od 8 mg/24 h do maksimalne doze od 16 mg/24 h.
English: Treatment of Restless Legs Syndrome
Croatian: Liječenje sindroma nemirnih nogu
English: In both arms treatment was titrated to optimal or maximum dose of 8 mg/24 h or 9 mg/day, respectively.
Croatian: U obje skupine liječenje je titrirano do odgovarajuće doze od 8 mg/24 h ili najveće doze od 9 mg/dan.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
Croatian: PODACI KOJE MORA MINIMALNO SADRŽAVATI MALO UNUTARNJE PAKIRANJE NALJEPNICA NA VREĆICI
English: • constipation, dry mouth, heartburn
Croatian: • zatvor, suha usta, žgaravica
English: Adverse reactions of increased creatine phosphokinase (CPK) were observed with rotigotine in clinical studies conducted in Japan.
Croatian: U kliničkim ispitivanjima provedenima u Japanu, s rotigotinom su opažene nuspojave povišene kreatin fosfokinaze (CPK).
English: • The maximum dose is 16 mg each day.
Croatian: • Najveća doza je 16 mg na dan.
English: Patients and carers should be made aware that behavioural symptoms of impulse control disorders including pathologic gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists, including rotigotine.
Croatian: Bolesnici i njegovatelji moraju biti svjesni da se u bolesnika liječenih agonistima dopamina uključujući rotigotin, mogu pojaviti bihevioralni simptomi poremećaja kontole nagona uključujući patološko kockanje, pojačani libido, hiperseksualnost, kompulzivno trošenje ili kupovanje, prejedanje i kompulzivno uzimanje hrane.
English: Application site skin reactions may occur and are usually mild or moderate in intensity.
Croatian: Na mjestu primjene flastera mogu se javiti reakcije na koži koje su obično blagog do umjerenog intenziteta.
English: Dosing in patients with early-stage Parkinson's disease:
Croatian: Doziranje u bolesnika u ranoj fazi Parkinsonove bolesti:
English: Clinical studies in Restless Legs Syndrome
Croatian: Klinička ispitivanja kod sindroma nemirnih nogu
English: Week 4
Croatian: Tjedan 4
English: Observed in studies performed in patients with Parkinson's disease Parkinson's disease
Croatian: eOpaženo u ispitivanjima provedenim na bolesnicima s Parkinsonovom bolesti
English: The maximum dose is 8 mg per day.
Croatian: Najveća doza je 8 mg na dan.
English: 7 transdermal patches 28 transdermal patches 30 transdermal patches
Croatian: OBLIK I SADRŽAJ 7 transdermalnih flastera 28 transdermalnih flastera 30 transdermalnih flastera
English: What Leganto is Leganto contains the active substance rotigotine.
Croatian: Što je Leganto Leganto sadrži djelatnu tvar rotigotin.
English: The strengths are 2 mg/24 h, 4 mg/24 h, 6 mg/24 h and 8 mg/24 h for the treatment of Parkinson's disease.
Croatian: Jačine su 2 mg/24 h, 4 mg/24 h, 6 mg/24 h i 8 mg/24 h za liječenje Parkinsonove bolesti.
English: • The maximum dose is 3 mg per day.
Croatian: • Najveća doza je 3 mg na dan.
English: At the beginning of the third week, you should take Leganto 6 mg (package marked with “Week 3”).
Croatian: Na početku trećeg tjedna primijenite Leganto 6 mg/24 h (pakiranje označeno „Tjedan 3“).
English: At the beginning of the fourth week, you should take Leganto 8 mg (package marked with “Week 4”).
Croatian: Na početku četvrtkog tjedna primijenite Leganto 8 mg/24 h (pakiranje označeno „Tjedan 4“).
English: For most patients an effective dose is reached within 3 or 4 weeks at doses of 6 mg/24 h or 8 mg/24 h, respectively.
Croatian: U većine bolesnika učinkovita doza postiže se za 3 ili 4 tjedna dozom od 6 mg/24 h, odnosno 8 mg/24 h.
English: Each patch of 30 cm contains 13.5 mg of rotigotine.
Croatian: Jedan flaster površine 30 cm2 sadrži 13,5 mg rotigotina.
English: At the end of maintenance, the mean UPDRS part III score had improved by 7.0 points in rotigotine-treated patients (baseline 29.6), and by 3.9 points in the placebo-group (baseline 32.0).
Croatian: Na kraju terapije održavanja, prosječna ocjena prema UPDRS (dio III) ljestvici popravila se za 7 bodova u bolesnika koji su liječeni rotigotinom (početno 29,6) te za 3,9 bodova u placebo-skupini (početno 32,0).
English: • From the second week your daily dose may be increased by 2 mg each week - until you get to the right maintenance dose for you.
Croatian: • Od drugog se tjedna dnevna doza može povećavati za 2 mg tjedno, dok se ne postigne odgovarajuća doza održavanja za Vas.
English: hypersexuality, libido increased), insomnia, sleep disorder, abnormal dreams, impulse-control disorders a,d
Croatian: (uključujući hiperseksualnost , povećanje libida), nesanica, poremećaj spavanja, abnormalni snovi, poremećaji kontrole nagonaa
English: Parkinson's disease
Croatian: Parkinsonovom bolešću
English: Each patch of 40 cm contains 18.0 mg of rotigotine.
Croatian: Jedan flaster površine 40 cm2 sadrži 18,0 mg rotigotina.
English: Each patch of 5 cm contains 2.25 mg of rotigotine.
Croatian: Jedan flaster površine 5 cm2 sadrži 2,25 mg rotigotina.
English: With rotigotine, the mean reductions in “off” time were 2.7 and 2.1 hours, respectively whereas in the placebo-treated arm a reduction of 0.9 hours was observed.
Croatian: U rotigotin-skupinama trajanje off razdoblja u prosjeku je bilo skraćeno za 2,7 h, odnosno 2,1 h, a u placebo-skupini za 0,9 h.
English: Orthostatic hypotension, hypertension
Croatian: Krvožilni poremećaji ortostatska hipotenzija, hipertenzija hipotenzija
English: At the beginning of the second week, you should take Leganto 4 mg (package marked with “Week 2”).
Croatian: Na početku drugog tjedna primijenite Leganto 4 mg/24 h (pakiranje označeno „Tjedan 2“).
English: Tell your doctor, pharmacist or nurse if you notice any side effects.
Croatian: Recite svom liječniku, ljekarniku ili medicinskoj sestri ako primijetite bilo koju nuspojavu.
English: • delusion
Croatian: • deluzije
English: • Stick the patch onto a different area of skin each day.
Croatian: • Zalijepite flaster svaki dan na drugo mjesto na koži.
English: With rotigotine, the mean improvement in the UPDRS score (Parts II + III) was -3.98 points (baseline 29.9 points) whereas in the placebo-treated arm a worsening of 1.31 points was observed (baseline 30.0 points).
Croatian: Sa rotigotinom prosječno poboljšanje ocjene prema UPDRS ljestvici (dio II + III) bilo je -3,98 bodova (početno 29,9 bodova), a u skupini koja je primjenjivala placebo zabilježeno je pogoršanje za 1,31 bod (početno 30,0 bodova).
English: e
Croatian: N
English: Patients in each treatment group were maintained for 6 months.
Croatian: Bolesnici u svakoj terapijskoj skupini su održavani na njihovim optimalnim dozama tijekom 6 mjeseci.
English: Pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists, including rotigotine (see section 4.4).
Croatian: U bolesnika liječenih agonistima dopamina, uključujući rotigotin, mogu se pojaviti patološko kockanje, pojačanje libida, hiperseksualnost, kompulzivno trošenje ili kupovanje, prejedanje i kompulzivno uzimanje hrane (vidjeti dio 4.4).
English: In trials where the application sites were rotated as reflected in the instructions provided in SmPC and package leaflet, 35.7% of 830 patients using the Leganto transdermal patch, experienced application site reactions.
Croatian: U ispitivanjima u kojima je mjesto primjene mijenjano u skladu s preporukama koje se nalaze u sažetku opisa svojstava lijeka i uputi o lijeku, u 35,7% od 830 bolesnika koji su primjenjivali Leganto transdermalni flaster zabilježene su reakcije na mjestu primjene.
English: Transdermal use.
Croatian: Transdermalni flaster.
English: Adverse drug reactions (ADRs) reported in more than 10% of patients treated with Leganto transdermal patch are nausea, vomiting, application site reactions, somnolence, dizziness and headache.
Croatian: Nuspojave zabilježene u više od 10% bolesnika koji su primjenjivali Leganto transdermalni flaster jesu mučnina, povraćanje, reakcije na mjestu primjene, somnolencija, omaglica i glavobolja.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI DOZNOJ JEDINICI LIJEKA 1 transdermalni flaster
English: This makes the S-shaped break in the liner open up.
Croatian: Savijte flaster na pola tako da se otvori S-prorez na sloju.
English: • Then put the sticky half of the patch onto your skin.
Croatian: • Namjestite ljepljivu stranu na kožu.
English: The patch should be applied to clean, dry, intact healthy skin on the abdomen, thigh, hip, flank, shoulder, or upper arm. Reapplication to the same site within 14 days should be avoided.
Croatian: Flaster se primjenjuje na čistu, suhu, neozlijeđenu zdravu kožu trbuha, bedara, bokova, slabinskog dijela leđa, ramena ili nadlaktice.
English: Hypertension Orthostatic hypotension
Croatian: Krvožilni poremećaji hipertenzija ortostatska hipotenzija hipotenzijae
English: Treatment discontinuation
Croatian: Prekid primjene lijeka
English: • skin irritations under the patch such as redness and itching
Croatian: • nadraženost kože ispod flastera, kao što su crvenilo i svrbež
English: Week 2.
Croatian: Tjedan 2.
English: You can also use a little baby oil to remove any stickiness that will not wash off.
Croatian: Ljepilo koje ne uspijete isprati vodom možete ukloniti dječjim uljem.
English: Side effects more likely at the start of treatment You may feel sick (nausea) and vomit at the start of treatment.
Croatian: Nuspojave za koje je vjerojatnije da će se pojaviti na početku liječenja
English: INTERMEDIATE BOX (WITHOUT BLUE BOX) BOX OF 28 PATCHES
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU SAMO VIŠESTRUKA PAKIRANJA SREDNJE PAKIRANJE (BEZ PLAVOG OKVIRA) KUTIJA S 28 FLASTERA
English: • abnormal heart rhythm
Croatian: • poremećaj srčanog ritma
English: • hiccups
Croatian: • štucavica
English: Adjustment of the dose is not necessary in patients with mild to severe renal impairment, including those requiring dialysis.
Croatian: U bolesnika s blagim do teškim oštećenjem bubrega, uključujući i bolesnike koji su na dijalizi, ne treba prilagođavati dozu.
English: For example a daily dose of 10 mg/24 h may be reached by applying one patch of 6 mg/24 h and one patch of 4 mg/24 h.
Croatian: Primjerice, dnevnu dozu od 10 mg/24 h moguće je postići primjenom jednog flastera od 6 mg/24 h i jednog flastera od 4 mg/24 h.
English: atrial fibrillation e, supraventricular tachycardia e
Croatian: Srčani poremećaji palpitacijee, fibrilacija atrijae, supraventrik ularna tahikardijae
English: Week 3.
Croatian: Tjedan 3.
English: In the double-blind study SP513 Part I, 213 patients received rotigotine, 227 received ropinirole and 117 patients received placebo.
Croatian: U dvostruko-slijepom ispitivanju SP513 I dio, 213 bolesnika primalo je rotigotin, 227 ropinirol i 117 placebo.
English: Week 2
Croatian: Tjedan 2
English: 28 transdermal patches.
Croatian: OBLIK I SADRŽAJ 28 transdermalna flastera.
English: Ear and labyrinth disorders
Croatian: Poremećaji uha i labirinta vrtoglavicae
English: • Thigh or hip.
Croatian: • bedro ili kuk
English: In the double blind study SP512 Part I, 177 patients received rotigotine and 96 patients received placebo.
Croatian: U dvostruko-slijepom ispitivanju SP512 I dio, 177 bolesnika primalo je rotigotin i 96 bolesnika primalo je placebo.
English: Week 3
Croatian: Tjedan 3
English: The mean reduction in the “off” time was 2.5 hours in the rotigotine arm, 2.8 hours in the pramipexole arm and 0.9 hours in the placebo arm. All differences between the active treatments and placebo were statistically significant.
Croatian: Vrijeme trajanja off razdoblja u prosjeku je skraćeno za 2,5 h u rotigotin-skupini, za 2,8 h u pramipeksol-skupini, a u placebo-skupini za 0,9 h.
English: Warnings and precautions Talk to your doctor or pharmacist before using Leganto.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primijenite Leganto.