FrancophonIA/ELRC3.0 huggingface dataset:
English: *Fusion protein consisting of portions of human VEGF (Vascular Endothelial Growth Factor) receptors 1 and 2 extracellular domains fused to the Fc portion of human IgG1 and produced in Chinese hamster ovary (CHO) K1 cells by recombinant DNA technology.
Danish: * Fusionsprotein, der består af dele af human VEGF (vaskulær endotelial vækstfaktor) receptorer 1 og 2 ekstracellulære domæner, som er fusioneret med Fc-delen af human IgG1 og fremstilles i K1ovarieceller fra kinesisk hamster (CHO) med rekombinant dna-teknologi.
English: During the second year of treatment patients in both the 2-week and 4-week adjustment groups received an average of 3.6 and 3.7 injections, respectively.
Danish: I løbet af det andet år af behandlingen havde patienterne i grupperne med justeringer på hhv. 2 uger og 4 uger gennemsnitlig modtaget 3,6 og 3,7 injektoner.
English: Eylea can help to stabilise, and in many cases, improve the vision loss related to wet AMD, CRVO, BRVO, DME and myopic CNV.
Danish: Eylea kan hjælpe med at stabilisere og i mange tilfælde forbedre det synstab, der er relateret til våd AMD, CRVO, BRVO, DME og myopisk CNV.
English: If visual and/or anatomic outcomes deteriorate, the treatment interval should be shortened accordingly to a minimum of two months during the first 12 months of treatment.
Danish: Hvis visuelle og/eller anatomiske undersøgelser bliver forværret, skal behandlingsintervallerne afkortes i overensstemmelse med dette til et minimum på to måneder i løbet af de første 12 måneders behandling.
English: The safety data described below include all adverse reactions from the eight phase III studies in the indications wet AMD, CRVO, BRVO, DME and myopic CNV with a reasonable possibility of causality to the injection procedure or medicinal product.
Danish: Sikkerhedsdataene beskrevet herunder inkluderer alle bivirkninger fra otte fase III-studier af indikationerne våd AMD, CRVO, BRVO, DME og myopisk CNV med en rimelig mulighed for årsagssammenhæng med injektionsproceduren eller lægemidlet.
English: The difference between treatment groups was statistically significant in favour of Eylea for the primary endpoint (change in BCVA) and confirmatory secondary efficacy endpoint (proportion of patients who gained 15 letters in BCVA) at week 24 compared to baseline.
Danish: Forskellen mellem behandlingsgrupperne var statistisk signifikant til fordel for Eylea med hensyn til det primære endepunkt (ændring i BCVA) og bekræftende sekundære virkningsendepunkt (andel patienter, der havde en forbedring på 15 bogstaver i BCVA) ved uge 24, sammenlignet med baseline.
English: Up-regulation of VEGF is associated with the breakdown of the blood retina barrier, increased vascular permeability, retinal oedema, and neovascularisation complications.
Danish: Opregulering af VEGF er forbundet med nedbrydning af blod-retina barrieren, øget vaskulær permeabilitet, retinalt ødem og neovaskularisationskomplikationer.
English: • Do not use this medicine after the expiry date which is stated on the carton and label after EXP.
Danish: • Brug ikke lægemidlet efter den udløbsdato, der står på pakningen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: - your doctor will check whether you have other risk factors that may increase the chance of a tear or detachment of one of the layers at the back of the eye (retinal detachment or tear, and retinal pigment epithelial detachment or tear), in which case Eylea must be given with caution.
Danish: - Din øjenlæge vil undersøge, om du har andre risikofaktorer, der kan øge risikoen for rifter i eller løsning af et af lagene bagest i øjet (løsning af eller rift i nethinden eller nethinde-pigmentepitelet).
English: The interval between two doses should not be shorter than one month.
Danish: Intervallet mellem to doser bør ikke være kortere end én måned.
English: These new blood vessels can cause the leak of blood components into the eye and eventual damage to tissues in the eye responsible for vision.
Danish: Disse nye blodkar kan medføre, at der lækkes bestanddele fra blodet ind i øjet, og dette kan evt. beskadige det væv i øjet, der gør dig i stand til at se.
English: Arterial thromboembolic events (ATEs) are adverse events potentially related to systemic VEGF inhibition.
Danish: Arterielle tromboemboliske hændelser (ATE'er) er bivirkninger, der potentielt er forbundet med systemisk VEGF-inhibition.
English: After opening the blister, proceed under aseptic conditions.
Danish: Efter at blisteren er åbnet, fortsættes proceduren under aseptiske betingelser.
English: F) Difference and 95% CI are calculated using Cochran-Mantel-Haenszel (CMH) test adjusted for country
Danish: F) Forskel og 95 % CI beregnes med Cochran-Mantel-Haenszel (CMH)-test justeret for land (landetildelinger)
English: Eylea should not be used during pregnancy unless the potential benefit outweighs the potential risk to the unborn child.
Danish: Eylea bør ikke anvendes under graviditeten, medmindre den potentielle fordel opvejer den potentielle risiko for det ufødte barn.
English: At week 100, the respective percentages were 32.6% and 37.1% of the Eylea 2Q8 groups and 8.2% and 15.6% of the control groups.
Danish: Ved uge 100 var procenterne hhv. 32,6 % og 37,1 % i Eylea 2Q8-grupperne og 8,2 % og 15,6 % i kontrolgrupperne.
English: Always discuss any suspected side effects with your doctor.
Danish: Tal altid med din læge, hvis du har mistanke om eventuelle bivirkninger.
English: In pharmacokinetic sub-studies in patients with CRVO, BRVO, DME or myopic CNV mean Cmax of free aflibercept in plasma were similar with values in the range of 0.03 to 0.05 microgram/ml and individual values not exceeding 0.14 microgram/ml.
Danish: I farmakokinetiske substudier hos patienter med CRVO, BRVO, DME eller myopisk CNV var middel-Cmax af frit aflibercept i plasma den samme, med værdier fra 0,03 til 0,05 mikrogram/ml, og de individuelle værdier var ikke over 0,14 mikrogram/ml.
English: If visual and/or anatomic outcomes deteriorate, the treatment interval should be shortened accordingly.
Danish: Hvis de visuelle og/eller anatomiske resultater forværres, skal behandlingsintervallet afkortes i henhold til dette.
English: - deterioration of eyesight - bloodshot eye caused by bleeding from small blood vessels in the outer layers of the eye - eye pain
Danish: - forringet syn - blodskudt øje på grund af blødning fra de små blodkar i øjets ydre lag (konjunktival blødning) - øjensmerter
English: There is a theoretical risk of arterial thromboembolic events, including stroke and myocardial infarction, following intravitreal use of VEGF inhibitors.
Danish: Der er en teoretisk risiko for arterielle tromboemboliske hændelser, herunder apopleksi og myokardieinfarkt, efter intravitreal anvendelse af VEGF-hæmmere.
English: The magnitude of these changes was similar to that seen in published studies, which corresponded to a 15-letter gain in Best Corrected Visual Acuity (BCVA).
Danish: Størrelsen af disse ændringer var lig de ændringer, der blev set i publicerede studier, som svarede til en forbedring på 15 bogstaver i Best Corrected Visual Acuity (BCVA).
English: Your doctor will then decide whether the treatment interval between injections may be kept at every two months or be gradually extended in 2- or 4-weekly intervals if your condition has been stable.
Danish: Din øjenlæge vil beslutte om behandlingsintervallet mellem injektionerne skal forblive på to måneder eller gradvist forlænges med 2- eller 4-ugers tillægsperioder, hvis din tilstand er stabil.
English: The beneficial effect of Eylea treatment on visual function was similar in the baseline subgroups of perfused and non-perfused patients.
Danish: Den gavnlige virkning af Eylea på visus var den samme i baseline-undergrupperne af patienter med perfusion og patienter uden perfusion.
English: Following intravitreal injection patients should be instructed to report any symptoms suggestive of endophthalmitis (e.g. eye pain, redness of the eye, photophobia, blurring of vision) without delay.
Danish: Efter intravitreal injektion skal patienterne instrueres i øjeblikkeligt at rapportere eventuelle symptomer på endophtalmitis (f.eks. øjensmerte, rødme i øjet, fotofobi, sløret syn).
English: • Use of povidone iodine or equivalent
Danish: • Anvendelse af povidoniodid eller tilsvarende
English: The extractable volume of the vial (100 microlitres) is not to be used in total.
Danish: Hætteglassets ekstraherbare volumen (100 mikroliter) anvendes ikke fuldt ud.
English: Your doctor may decide to stop treatment with Eylea, if you are not benefiting from continued treatment.
Danish: Øjenlægen kan beslutte at stoppe behandlingen med Eylea, hvis du ikke har nogen gavn af fortsat behandling.
English: Delivers a single dose of 2 mg/0.05 ml.
Danish: Giver en enkeltdosis på 2 mg/0,05 ml.
English: - if you have a history of seeing flashes of light or floaters and if you have a sudden increase of size and number of floaters.
Danish: - Hvis du tidligere har set blinkende lys eller ”flyvende fluer”, og hvis de "flyvende fluer" pludselig øger i antal eller bliver større.
English: All patients received monthly doses of Eylea 2 mg for 3 months, followed by one injection after a further 2 month interval.
Danish: Alle patienter modtog månedlige doser af Eylea på 2 mg i 3 måneder efterfulgt af én injektion efter yderligere 2 måneder.
English: Clinical efficacy and safety wet AMD
Danish: Klinisk virkning og sikkerhed
English: Furthermore, in the 4-week adjustment group 40.7% of patients were extended to 16 week intervals.
Danish: Derudover var 40,7 % af patienterne, i gruppen med justeringer på 4 uger, forlænget til 16 ugers intervaller.
English: B) Difference and confidence interval (CI) are calculated using Cochran-Mantel-Haenszel (CMH) test adjusted for region (America vs. rest of the world for COPERNICUS and
Danish: B) Forskel og konfidensinterval (CI) beregnes med Cochran-Mantel-Haenszel (CMH)-test justeret for område (Amerika vs. resten af verden for COPERNICUS og Europa vs.
English: - blindness - clouding of the lens due to injury (traumatic cataract) - inflammation of the gel-like substance inside the eye - pus in the eye
Danish: - blindhed - uklarhed i linsen på grund af en skade (traumatisk katarakt) - inflammation (betændelseslignende reaktion) i den geléagtige substans inden i øjet - pus i øjet
English: At week 52, 27.7% and 29.1% of the Eylea 2Q8 groups, and 7.5% and 14.3% of the control groups experienced a ≥2 step improvement in the DRSS.
Danish: Ved uge 52 oplevede 27,7 % og 29,1 % i Eylea 2Q8-grupperne, og 7,5 % og 14,3 % i kontrolgrupperne en forbedring på ≥ 2 trin på DRSS.
English: Difference in LS
Danish: Forskel i LS gennemsnitlig
English: • The safety and efficacy of Eylea therapy administered to both eyes concurrently have not been systematically studied (see section 5.1).
Danish: • Eyleas sikkerhed og virkning ved administration i begge øjne samtidigt er ikke blevet systematisk undersøgt (se pkt.
English: The primary efficacy endpoint was mean change in BCVA from baseline to week 52.
Danish: Det primære endepunkt for virkning var en middelændring i BCVA fra baseline til uge 52.
English: When ready to administer Eylea, open the carton and remove the sterilised blister.
Danish: Når du er klar til at administrere Eylea, åbner du æsken, og fjerner den steriliserede blister.
English: 52 Weeks
Danish: 52 uger
English: In the laser group, where patients were eligible for rescue treatment with Eylea from week 24, the proportion of perfused patients increased to 78% by week 52.
Danish: I lasergruppen, hvor patienterne var kvalificeret til erstatningsbehandling med Eylea fra uge 24, steg andelen af patienter med perfusion til 78,0 % i uge 52.
English: As with all therapeutic proteins, there is a possibility for an immune reaction (formation of antibodies) with Eylea.
Danish: Som med alle proteiner, der anvendes i behandlingsøjemed, er der en mulighed for en immunreaktion (dannelse af antistoffer) ved anvendelse af Eylea.
English: A secondary efficacy endpoint was change in visual acuity at week 24 compared to baseline, which was statistically significant in favour of Eylea in the VIBRANT study.
Danish: Et sekundært virkningsendepunkt var ændring i visus ved uge 24 sammenlignet med baseline, som var statistisk signifikant til fordel for Eylea i VIBRANT-studiet.
English: - The other ingredients are: polysorbate 20, sodium dihydrogen phosphate monohydrate (for pH adjustment), disodium hydrogen phosphate heptahydrate (for pH adjustment), sodium chloride, sucrose, water for injection.
Danish: - Øvrige indholdsstoffer: polysorbat 20, natiumdihydrogenphosphatmonohydrat (til justering af pH), dinatriumhydrogenphosphatheptahydrat (til justering af pH), natriumchlorid, saccharose, vand til injektionsvæsker.
English: If your condition starts to worsen with a longer treatment interval, your doctor will shorten the interval accordingly.
Danish: Hvis din tilstand begynder at bliver forværret, når intervallet mellem behandlingerne øges, vil øjenlægen afkorte intervallet derefter.
English: In the laser group 67 patients received rescue treatment with Eylea beginning at week 24 (Active Control/ Eylea 2mg group), which resulted in improvement of visual acuity by about 5 letters from week 24 to 52.
Danish: I lasergruppen fik 67 patienter erstatningsbehandling med Eylea begyndende i uge 24 (aktiv kontrol/ Eylea 2 mg-gruppe), hvilket resulterede i en bedring af visus med omkring 5 bogstaver fra uge 24 til 52.
English: ** Culture positive and culture negative endophthalmitis *** During the post-marketing period, reports of hypersensitivity included rash, pruritus, urticaria, and isolated cases of severe anaphylactic/anaphylactoid reactions.
Danish: ** Med positiv og negativ dyrkning for endoftalmitis *** Under overvågningen efter markedsføringen omfattede rapporterne om allergiske reaktioner udslæt, pruritus, urticaria og isolerede tilfælde af alvorlige anafylaktiske/anafylaktoide reaktioner.
English: Diabetic macular oedema is a consequence of diabetic retinopathy and is characterised by increased vasopermeability and damage to the retinal capillaries which may result in loss of visual acuity.
Danish: Diabetisk makulaødem er en konsekvens af diabetisk retinopati, og er karakteriseret af øget vasopermeabilitet og beskadigelse af kapillærerne i nethinden, hvilket kan føre til nedsat visus.
English: The interval between two injections should not be shorter than one month.
Danish: Intervallet mellem to injektioner bør ikke være kortere end én måned.
English: Difference in LS meanA,C,D,E)
Danish: Forskel i LS-gennemsnitA,C,D,E)
English: At week 100 the decrease was maintained with -195.8 and -191.1 microns for the 2Q8 Eylea groups and -85.7 and -83.9 microns for the control groups, in the VIVIDDME and VISTADME studies, respectively.
Danish: Reduktionen var opretholdt ved uge 100 med -195,8 og -191,1 mikrometer for Eylea 2Q8-grupperne og -85,7 og -83,9 mikrometer for kontrolgrupperne i hhv. VIVIDDME- og VISTADME-studierne.
English: The extractable volume of the syringe (90 microlitres) is not to be used in total.
Danish: Injektionssprøjtens ekstraherbare volumen (90 mikroliter) anvendes ikke fuldt ud.
English: Pharmacokinetic analysis of patients in the VIEW2 study, of which 40% had renal impairment (24% mild, 15% moderate, and 1% severe), revealed no differences with respect to plasma concentrations of active drug after intravitreal administration every 4 or 8 weeks.
Danish: Farmakokinetisk analyse af patienter i VIEW2-studiet, hvor 40 % af patienterne havde nedsat nyrefunktion (24 % i mild grad, 15 % i moderat grad og 1 % i svær grad) viste ingen forskelle med hensyn til plasmakoncentrationer af det aktive stof efter intravitreal administration hver 4. eller 8. uge.
English: This provides a usable amount to deliver a single dose of 50 microlitres containing 2 mg aflibercept.
Danish: Dette giver en anvendelig mængde til at indgive en enkelt dosis på 50 mikroliter, der indeholder 2 mg aflibercept.
English: In the VIVIDDME and the VISTADME studies, a statistically significant greater mean decrease in CRT from baseline to week 52 was observed in patients treated with Eylea than with the laser control,192.4 and -183.1 microns for the 2Q8 Eylea groups and -66.2 and -73.3 microns for the control groups, respectively.
Danish: I VIVIDDME- og VISTADME-studierne sås en statistisk signifikant højere gennemsnitlig reduktion i CRT fra baseline ved uge 52 hos patienter behandlet med Eylea sammenlignet med laserkontrolgruppen - hhv. -192,4 og -183,1 mikrometer for Eylea 2Q8-grupperne og -66,2 og -73,3 mikrometer for kontrolgrupperne).
English: After opening the vial, proceed under aseptic conditions.
Danish: Efter at hætteglasset er åbnet, fortsættes proceduren under aseptiske betingelser.
English: Since the vial contains more volume (100 microlitres) than the recommended dose (50 microlitres), a part of the volume contained in the vial has to be discarded prior to the administration.
Danish: Da hætteglasset indeholder mere (100 mikroliter) end den anbefalede dosis (50 mikroliter), skal en del af indholdet i hætteglasset bortskaffes før indgiften.
English: Remove the plastic cap and disinfect the outer part of the rubber stopper of the vial.
Danish: Plasticlåget fjernes, og den ydre del af hætteglassets gummiprop desinficeres.
English: • How to prepare for Eylea treatment
Danish: • Forberedelse til Eylea-behandling
English: Your doctor may decide to stop treatment with Eylea if it is determined that you are not benefiting from continued treatment.
Danish: Øjenlægen kan vælge at stoppe med behandlingen med Eylea, hvis det viser sig, at du ikke har gavn af fortsat behandling.
English: Ranibizumab 0.5Q4 (ranibizumab 0.5 mg every 4 weeks)
Danish: Ranibizumab 0,5Q4 (ranibizumab 0,5 mg hver 4. uge)
English: Your doctor will determine the most appropriate treatment schedule for you.
Danish: Din øjenlæge vil fastlægge en behandlingsplan, der passer til dig.
English: 3) Eylea administered at 0.5 mg every 4 weeks (Eylea 0.5Q4); and 4) ranibizumab administered at 0.5 mg every 4 weeks (ranibizumab 0.5Q4).
Danish: 3) Eylea 0,5 mg administreret hver 4. uge (Eylea 0,5Q4); og 4) ranibizumab 0,5 mg administreret hver 4. uge (ranibizumab 0,5Q4).
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS LABEL
Danish: MINDSTEKRAV TIL MÆRKNING PÅ SMÅ INDRE EMBALLAGER Etiket
English: Endophthalmitis**, Retinal detachment, Retinal tear, Iritis,
Danish: Endoftalmitis**, Retinaløsning, Rift i retina, Iritis,
English: To remove the syringe cap, hold the syringe in one hand while using the other hand to grasp the syringe cap with the thumb and fore finger.
Danish: Hold injektionssprøjten i én hånd for at fjerne låget på injektionssprøjten, mens den anden hånd bruges til at gribe fat i låget på injektionssprøjten med tommel- og pegefinger.
English: Since the pre-filled syringe contains more volume (90 microlitres) than the recommended dose (50 microlitres), a part of the volume contained in the syringe has to be discarded prior to the administration.
Danish: Da den fyldte injektionssprøjte indeholder mere (90 mikroliter) end den anbefalede dosis (50 mikroliter), skal en del af indholdet i injektionssprøjten bortskaffes før indgiften.
English: The fixed regimen for Eylea rescue was three times Eylea 2mg every 4 weeks followed by injections every 8 weeks.
Danish: Det faste regime for erstatningsbehandling med Eylea var Eylea 2 mg tre gange med 4 ugers interval efterfulgt af injektioner hver 8. uge.
English: • Eylea is not recommended during breast-feeding.
Danish: • Eylea anbefales ikke under amning.
English: INFORMATION IN BRAILLE Justification for not including Braille accepted.
Danish: INFORMATION I BRAILLESKRIFT Fritaget for krav om brailleskrift.
English: Weighted differenceA,B,E) (95% CI)
Danish: Vægtet forskelA,B E) (95 % CI)
English: 90 microlitres of solution in pre-filled syringe (type I glass) marked with a black dosing line, with a plunger stopper (elastomeric rubber) and a Luer lock adaptor with a tip cap (elastomeric rubber).
Danish: 90 mikroliter opløsning i en fyldt injektionssprøjte (type I-glas) mærket med en sort doseringslinje, med en stempelprop (elastomergummi) og en adapter med luer-lås og et spidslåg (elastomergummi).
English: 1) Eylea administered at 2 mg every 8 weeks following 3 initial monthly doses (Eylea 2Q8); 2) Eylea administered at 2 mg every 4 weeks (Eylea 2Q4);
Danish: 1) Eylea 2 mg administreret hver 8. uge efter 3 indledende månedlige doser (Eylea 2Q8); 2) Eylea 2 mg administreret hver 4. uge (Eylea 2Q4);
English: • What are the steps following treatment with Eylea
Danish: • Hvad sker der efter behandlingen med Eylea
English: A total of 181 patients were treated and evaluable for efficacy (91 with Eylea).
Danish: I alt 181 patienter blev behandlet og evalueret for virkning (91 med Eylea).
English: The systemic use of VEGF inhibitors, substances similar to those contained in Eylea, is potentially related to the risk of blood clots blocking blood vessels (arterial thromboembolic events) which may lead to heart attack or stroke.
Danish: Brug af VEGF-hæmmere, stoffer, der ligner det stof, der findes i Eylea, i kroppen (systemisk brug) er muligvis forbundet med risiko for blodpropper, der blokerer blodkar (arterielle trombotiske bivirkninger), hvilket kan medføre hjerteslag eller slagtilfælde.
English: 24 Weeks
Danish: 24 uger
English: In a pharmacokinetic sub-study in 6 neovascular wet AMD patients with frequent sampling, maximum plasma concentrations of free aflibercept (systemic Cmax) were low, with a mean of approximately 0.02 microgram/ml (range 0 to 0.054) within 1 to 3 days after a 2 mg intravitreal injection, and were undetectable two weeks following dosage in almost all patients.
Danish: I et farmakokinetisk substudie med 6 patienter med neovaskulær våd AMD med hyppig prøvetagning var maksimale plasmakoncentrationer af frit aflibercept (systemisk Cmax) lave med en middelværdi på ca. 0,02 mikrogram/ml (område 0 til 0,054) inden for 1 til 3 dage efter en 2 mg intravitreal injektion og kunne ikke påvises to uger efter indgiften hos de fleste patienter.
English: Patients were randomly assigned in a 3:1 ratio to receive either 2 mg Eylea intravitreally or sham injections administered once at study start with additional injections given monthly in case of disease persistence or recurrence until week 24, when the primary endpoint was assessed.
Danish: Patienterne blev fordelt tilfældigt i forholdet 3:1 til at få enten 2 mg Eylea intravitrealt eller shaminjektioner administreret én gang ved studiestart og yderligere injektioner månedligt i tilfælde af vedvarende sygdom eller sygdomstilbagefald indtil uge 24, hvor det primære endepunkt blev vurderet.
English: Aflibercept is slowly absorbed from the eye into the systemic circulation after intravitreal administration and is predominately observed in the systemic circulation as an inactive, stable complex with VEGF; however only “free aflibercept” is able to bind endogenous VEGF.
Danish: Aflibercept absorberes langsomt fra øjet i det systemiske kredsløb efter intravitreal administration og observeres hovedsageligt i det systemiske kredsløb som et inaktivt, stabilt kompleks med VEGF.
English: Open the sterile blister in clean administration room only.
Danish: Den sterile blisterpakning må kun åbnes i et rent administrationsrum.
English: Mean Change in Visual Acuity from Baseline to Week 96 for the Combined Data from the View1 and View2 Studies
Danish: Gennemsnitlig ændring af visus fra baseline til uge 96 for kombinerede data fra View1- og View2-studierne
English: F) In COPERNICUS study, both control group and Eylea 2mg patients received Eylea 2 mg on an as-needed basis as frequently as every 4 weeks starting from week 52 to week 96;
Danish: F) I COPERNICUS-studiet fik både kontrolgruppen og Eylea 2 mg-patienterne Eylea 2 mg efter behov så ofte som hver 4. uge med start fra uge 52 til uge 96.
English: or central RVO (CRVO)), - impaired vision due to diabetic macular oedema (DME), - impaired vision due to myopic choroidal neovascularisation (myopic CNV).
Danish: (BRVO) eller centralveneokklusion (CRVO)), - nedsat syn på grund af diabetisk makulaødem (DME), - nedsat syn på grund af myopisk koroidal neovaskularisering (myopisk CNV).