FrancophonIA/ELRC3.0 huggingface dataset:
English: Tell your doctor if you have or have had: - liver or kidney problems - infections if you suffer from an infection, this will be treated before you start using LITAK.
Croatian: Obavijestite liječnika ako imate ili ste imali: - tegobe s jetrom ili bubrezima - infekcije: ako bolujete od infekcije, potrebno ju je liječiti prije nego počnete primjenjivati LITAK. primijetite li ikakve znakove infekcije (kao što su simptomi slični gripi ili vrućica) tijekom ili nakon liječenja lijekom LITAK, odmah obavijestite svog liječnika.
English: Very common: purpura Common: petechiae, haemorrhages * Uncommon: phlebitis
Croatian: Vrlo često: purpura Često: petehije, hemoragije* Manje često: flebitis
English: - The other ingredients are sodium chloride, sodium hydroxide (for pH adjustment), hydrochloric acid
Croatian: - Drugi sastojci su natrijev klorid, natrijev hidroksid (za podešavanje pH), kloridna kiselina (za podešavanje pH) i voda za injekcije.
English: Eye inflammation.
Croatian: Poremećaji oka
English: Treatment with these agents is associated with the occurrence of second malignancies.
Croatian: Liječenje ovim lijekovima može dovesti do pojave sekudarnih zloćudnih bolesti.
English: Additional followup and evaluation may be warranted if no alternative diagnosis can be established.
Croatian: Ako se ne ustanovi druga dijagnoza, daljnje praćenje i ocjena stanja bolesnika može biti opravdana.
English: Parenteral medicinal products should be inspected visually for particulate matter and discoloration prior to administration.
Croatian: Parenteralne lijekove potrebno je prije primjene vizualno provjeriti na prisutnost čestica ili promjenu boje.
English: Special handling precautions (see package leaflet)
Croatian: Posebne mjere opreza pri rukovanju (vidjeti uputu o lijeku) Samo za jednokratnu primjenu
English: Very common: immunosuppression * Rare: graft-versus-host disease *
Croatian: Poremećaji imunološkog sustava Vrlo često: imunosupresija* Rijetko: reakcija presatka protiv domaćina*
English: Immediate discontinuation of therapy, careful observation, and initiation of appropriate supportive measures (blood transfusions, dialysis, haemofiltration, anti-infectious therapy, etc.) are the indicated treatment of overdose of cladribine.
Croatian: U slučaju predoziranja kladribina treba odmah prekinuti terapiju, pažljivo promatrati bolesnika i primijeniti odgovarajuće potporne mjere (transfuzija krvi, dijaliza, hemofiltracija, antiinfektivna terapija).
English: If you use more LITAK than you should In case you inject an incorrect dose, tell your doctor immediately.
Croatian: U slučaju da ubrizgate krivu dozu, odmah obavijestite liječnika.
English: Common: oedema, malaise, pain
Croatian: Često: edemi, opće loše stanje, bol
English: Very rare side effects (may affect up to 1 in 10.000 people) Depression, epileptic attack.
Croatian: Vrlo rijetke nuspojave (mogu se javiti u najviše 1 na 10 000 osoba) depresija, epileptički napadaj otok vjeđe krvni ugrušak u plućima upala žučnog mjehura smanjena funkcija organa zbog velikih količina posebne tvari u tijelu (glikoproteina).
English: - one sterile injection needle (e.g. 0.5 x 19 mm, 25 G x ¾''), - alcohol wipes,
Croatian: Nemojte koristiti bočice koje su oštećene ili otopinu koja nije bistra ili sadrži čestice. - jedna sterilna štrcaljka (npr. 10 ml LUER štrcaljka), - jedna sterilna injekcijska igla (npr. 0,5 x 19 mm, 25 G x ¾''), - rupčići natopljeni alkoholom, - spremnik otporan na probadanje za sigurno odlaganje upotrijebljenih štrcaljki.
English: Non-haematological adverse reactions
Croatian: Nehematološke nuspojave
English: Careful treatment is required in patients with known or suspected renal or hepatic impairment.
Croatian: Bolesnike u kojih je potvrđeno ili se sumnja na oštećenje funkcije bubrega ili jetre treba pažljivo liječiti.
English: Sleepiness, numbness and tingling of the skin, feebleness, inactivity, disorder of peripheral nerves, confusion, impaired ability to coordinate movements.
Croatian: Manje česte nuspojave (mogu se javiti u najviše 1 na 100 osoba) anemija uzrokovana raspadom crvenih krvnih stanica pospanost, utrnulost i trnci u koži, slabost, tromost, poremećaj perifernih živaca, smetenost, narušena sposobnost koordinacije pokreta upala oka grlobolja upala vena veliki gubitak na tjelesnoj težini.
English: LITAK should be inspected visually for particulate matter and discoloration prior to administration.
Croatian: Prije primjene treba vizualno provjeriti da LITAK ne sadrži vidljive čestice i da nije došlo do promjene boje.
English: Uncommon: somnolence, paraesthesia, lethargy, polyneuropathy, confusion, ataxia
Croatian: Manje često: somnolencija, parestezija, letargija, polineuropatija, konfuzija, ataksija Rijetko: apopleksija, neurološki poremećaji govora i gutanja Vrlo rijetko: depresija, epileptički napadaji
English: Rare: hepatic failure
Croatian: Rijetko: hipereozinofilija
English: Cladribine is a cytostatic agent.
Croatian: Kladribin je citostatik.
English: Stroke.
Croatian: OBLIK
English: Disturbances in speech and swallowing.
Croatian: Opći poremećaji i reakcije na mjestu primjene
English: Be sure that the tip of the needle is in the solution.
Croatian: Vrh igle mora biti uronjen u otopinu.
English: Patients with suspected PML should not receive further treatment with cladribine.
Croatian: Liječenje kladribinom treba obustaviti u bolesnika u kojih postoji sumnja na PML.
English: Very common: pancytopenia/myelosuppression *, neutropenia, thrombocytopenia, anemia, lymphopenia Uncommon: haemolytic anaemia * Rare: hypereosinophilia
Croatian: Poremećaji krvi i limfnog sustava Vrlo često: pancitopenija/mijelosupresija*, neutropenija, trombocitopenija, anemija, limfopenija
English: Subcutaneous use
Croatian: Citotoksično
English: Male: 82%
Croatian: Muškarci: 82 %
English: • Ringing in ears
Croatian: • Zvonjenje u ušima
English: Dose adjustment is usually not required.
Croatian: Prilagodba doze obično nije potrebna.
English: Number at risk:
Croatian: Broj pod rizikom:
English: • A wound that does not heal.
Croatian: • Rana koja ne zarasta.
English: Median age: 64 years.
Croatian: Medijan dobi: 64 godine.
English: The usual dose is 60 mg, however your doctor will decide on the right dose for you.
Croatian: Uobičajena doza je 60 mg, ali će liječnik odlučiti koja je doza odgovarajuća za Vas.
English: Swallow the tablet with a full glass of water.
Croatian: Progutajte tabletu s punom čašom vode.
English: In case of such combination, INR values should be monitored.
Croatian: U slučaju takve kombinacije, potrebno je pratiti vrijednosti INR-a.
English: Do not crush the tablets.
Croatian: Nemojte drobiti tablete.
English: Tell your doctor straight away if you notice any of the following side effects - you may need urgent medical treatment:
Croatian: Odmah recite svom liječniku ako primijetite bilo koju od sljedećih nuspojava - moguće je da trebate hitno liječenje:
English: CABOMETYX is not recommended for children or adolescents.
Croatian: CABOMETYX se ne preporučuje za djecu ili adolescente.
English: The tablets should be swallowed whole and not crushed.
Croatian: Tablete se trebaju progutati cijele i ne smije ih se zdrobiti.
English: You should continue to take this medicine until your doctor decides to stop your treatment.
Croatian: Trebate nastaviti uzimati ovaj lijek sve dok liječnik ne odluči prekinuti liječenje.
English: Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli bilo koje druge lijekove uključujući lijekove nabavljene bez recepta.
English: ORR (partial responses only) Stable disease
Croatian: ORR (samo parcijalni odgovor) Stabilna bolest
English: Interrupt treatment.
Croatian: Prekinite liječenje.
English: When dose reduction is necessary, it is recommended to reduce to 40 mg daily, and then to 20 mg daily.
Croatian: Kada je potrebno smanjenje doze, preporučuje se smanjenje na 40 mg dnevno, a zatim na 20 mg dnevno.
English: Injury, poisoning and procedural complications wound complications
Croatian: Ozljede, trovanja i proceduralne komplikacije komplikacija rane
English: CABOMETYX should be taken once a day.
Croatian: CABOMETYX se treba uzimati jednom na dan.
English: Perforations and fistulas
Croatian: Perforacije i fistule
English: Caucasian: 56%, Asian: 34%
Croatian: Bijelci: 56 %; Azijati: 34 %
English: Comparable results for OS were observed with a follow-up analysis (descriptive) at 430 events.
Croatian: Usporedivi rezultati za OS zabilježeni su u analizi praćenja (deskriptivnoj) na 430 događaja.
English: • Increase in the level of bilirubin in the blood (which may result in jaundice/yellow skin or eyes)
Croatian: • Povišenje bilirubina u krvi (što može dovesti do žutice/žutila kože ili očiju)
English: As most events occur early in the course of treatment, the physician should evaluate the patient closely during the first eight weeks of treatment to determine if dose modifications are warranted.
Croatian: S obzirom da se većina događaja razvija u ranoj fazi liječenja, liječnik mora pažljivo pratiti bolesnika tijekom prvih osam tjedana liječenja kako bi odredio jesu li potrebne prilagodbe doze.
English: Frequencies are based on all grades and defined as: very common (≥1/10), common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); not known (cannot be estimated from the available data).
Croatian: Učestalost se temelji na svim stupnjevima i definira se kao: vrlo često (≥1/10), često (≥1/100 i<1/10); manje često (≥1/1000 i<1/100); nepoznato (ne može se procijeniti iz dostupnih podataka).
English: One event was Grade 3; the remainder were Grade 2.
Croatian: Jedan događaj bio je 3. stupnja, ostali su bili 2.stupnja.
English: Talk to your doctor or pharmacist before taking CABOMETYX if you:
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete CABOMETYX ako:
English: Metabolic clinical laboratory parameters should be monitored at least weekly or as deemed clinically appropriate to assess any possible changing trends.
Croatian: Metaboličke kliničke laboratorijske parametre mora se pratiti barem jednom tjedno ili kako se klinički smatra potrebnim za procjenu bilo kojih mogućih promjena.
English: The effects of CABOMETYX in people younger than 18 years old are not known.
Croatian: Učinci CABOMETYXA u osoba mlađih od 18 godina nisu poznati.
English: 4 stratified Cochran-Mantel-Haenszel (CMH) test
Croatian: 4 stratificirani Cochran-Mantel-Haenszelov (CMH) test
English: Not known (proportion of people affected not known)
Croatian: Nepoznato (nije poznat udio osoba u kojih se javlja)
English: The clinical relevance of the observed neoplastic lesions in rats is uncertain, but likely to be low.
Croatian: Klinička značajnost neoplastičnih lezija opaženih u štakora nije poznata, ali je vjerojatno mala.
English: 1 stratified log-rank test
Croatian: 1 stratificirani log-rang test
English: For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.
Croatian: Za sve informacije o ovom lijeku obratite se lokalnom predstavnik nositelja odobrenja za stavljanje lijeka u promet.
English: If you take more CABOMETYX than you should
Croatian: Ako uzmete više CABOMETYXA nego što ste trebali
English: Complete responses (CR) Partial responses (PR) ORR (CR+PR)) p-value1,4
Croatian: Potpuni odgovori (CR) Djelomični odgovori (PR) ORR (CR+PR)) p-vrijednost1,4
English: Partial Response Median time to First Response, months (95% CI) Stable Disease as Best Response Progressive Disease as Best Response 1 chi-squared test
Croatian: Parcijalni odgovor Medijan vremena do prvog odgovora, mjeseci (95 % CI) Stabilna bolest kao najbolji odgovor Progresivna bolest kao najbolji odgovor
English: Two dose reductions were required in 19.3% of patients.
Croatian: Dva smanjenja doza bila su potrebna u 19,3 % bolesnika.
English: Grade 1 and Grade 2 adverse reactions which are tolerable and easily managed
Croatian: Nuspojave 1. i 2. stupnja koje su podnošljive i lako se zbrinjavaju
English: This effect was not associated with a change in cardiac wave form morphology or new rhythms.
Croatian: Ovaj učinak nije bio povezan s promjenom oblika srčane krivulje ili promjenama ritma.
English: Dose reductions are recommended for events that, if persistent, could become serious or intolerable.
Croatian: Smanjenje doze se preporučuje u slučaju nuspojava koje, ako potraju, mogu postati ozbiljne ili nepodnošljive.
English: Tell your doctor if any of these affect you.
Croatian: Recite liječniku ako se bilo što od navedenog odnosi na Vas.
English: Patients should be monitored for signs and symptoms of hepatic encephalopathy.
Croatian: Bolesnike je potrebno pratiti radi znakova i simptoma hepatičke encefalopatije.
English: Tumor assessments were conducted every 8 weeks for the first 12 months, then every 12 weeks thereafter.
Croatian: Procjene tumora provođene su svakih 8 tjedana tijekom prvih 12 mjeseci, a nakon toga svakih 12 tjedana.
English: Institute appropriate medical care.
Croatian: Uvedite odgovarajuću medicinsku njegu.
English: No dose adjustment is necessary based on ethnicity (see section 5.2)
Croatian: Nije potrebna prilagodba doza na temelju etničke pripadnosti (vidjeti dio 5.2).
English: If there are still 12 hours or more before your next dose is due, then take the missed dose as soon as you remember.
Croatian: Ako još uvijek ima 12 sati ili više do Vaše sljedeće doze, uzmite propuštenu dozu čim se sjetite.
English: Take your next dose at the normal time.
Croatian: Svoju sljedeću dozu uzmite u uobičajeno vrijeme.
English: You should tell your doctor about every medicine, but in particular if taking:
Croatian: Svojeg liječnika trebate obavijestiti o svim lijekovima, posebice ako su to:
English: If you take CABOMETYX whilst using oral contraceptives, the oral contraceptives may be ineffective.
Croatian: Ako uzimate CABOMETYX istovremeno s oralnim kontraceptivima, oralni kontraceptivi mogu biti nedjelotvorni.
English: Subjects with untreated, or incompletely treated, varices with bleeding or high risk for bleeding were also excluded from this study.
Croatian: Ispitanici s neliječenim ili nepotpuno izliječenim varikozitetima s krvarenjem ili visokim rizikom od krvarenja također su bili isključeni iz ispitivanja.
English: • Decreased appetite, weight loss, altered sense of taste
Croatian: • Smanjen apetit, gubitak na tjelesnoj težini, promijenjen osjet okusa
English: Two dose reductions were required in 33% of patients.
Croatian: Dva smanjenja doza bila su potrebna u 33 % bolesnika.
English: No specific dose adjustment for the use of cabozantinib in older people (≥ 65 years) is recommended.
Croatian: Nije preporučena specifična prilagodba doze prilikom primjene kabozantiniba u starijih osoba (≥ 65 godina).
English: Avoid consuming grapefruitcontaining products for as long as you are using this medicine, as they may increase the levels of CABOMETYX in your blood.
Croatian: Izbjegavajte uzimanje bilo kakvih proizvoda koji sadrže grejp sve dok uzimate ovaj lijek jer Vam mogu povećati razine CABOMETYXA u krvi.
English: The safety and efficacy of cabozantinib in children and adolescents aged <18 years have not yet been established.
Croatian: Sigurnost i djelotvornost kabozantiniba u djece i adolescenata u dobi do 18 godina nisu još ustanovljene.
English: Gastrointestinal (GI) perforation
Croatian: Gastrointestinalna (GI) perforacija
English: Other medicines and CABOMETYX
Croatian: Drugi lijekovi i CABOMETYX
English: The carcinogenic potential of cabozantinib has been evaluated in two species: rasH2 transgenic mice and Sprague-Dawley rats.
Croatian: Kancerogeni potencijal kabozantiniba procijenjen je u dvije vrste: rasH2 transgeničnih miševa i Sprague-Dawley štakora.
English: You should not eat anything for at least 2 hours before taking CABOMETYX and for 1 hour after taking the medicine.
Croatian: Ne smijete ništa jesti najmanje 2 sata prije uzimanja CABOMETYXA i 1 sat nakon uzimanja lijeka.
English: Keep in mind that treatment with CABOMETYX may make you feel tired or weak and can affect your ability to drive or use machines.
Croatian: Imajte na umu da se zbog liječenja CABOMETYXOM možete osjećati umorno ili slabo i to može utjecati na Vašu sposobnost upravljanja vozilima ili rada sa strojevima.
English: This could mean that your doctor needs to change the dose(s) that you take.
Croatian: To može značiti da Vam liječnik treba promijeniti doze koje uzimate.
English: Approximately 75% of patients had a nephrectomy prior to onset of treatment.
Croatian: U približno 75 % bolesnika bila je provedena nefrektomija prije početka liječenja.
English: • Dry mouth and pain in the mouth
Croatian: • Suha usta i bol u ustima
English: If you get serious side effects, your doctor may decide to change your dose or stop treatment earlier than originally planned.
Croatian: Ako Vam se jave ozbiljne nuspojave liječnik može odlučiti promijeniti Vam dozu ili prekinuti liječenje ranije nego što je planirano u početku.
English: Your doctor will tell you if you need your dose adjusted.
Croatian: Vaš će Vam liječnik reći trebate li prilagoditi dozu.
English: Talk to your doctor about which methods of contraception are appropriate while you are taking CABOMETYX (see also under Other medicines and CABOMETYX, above).
Croatian: Razgovarate s liječnikom o tome koje su metode kontracepcije odgovarajuće za vrijeme uzimanja CABOMETYXA (pogledajte također dio Drugi lijekovi i CABOMETYX).
English: RPLS is rare (it affects less than 1 in 1000 people).
Croatian: RPLS se rijetko javlja (javlja se u manje od 1 na 1000 osoba).
English: 30.3 (14.6, NE)
Croatian: 30,3 (14,6; NP)
English: Talk to your doctor BEFORE taking CABOMETYX if you or your partner are considering or planning to have a baby after your treatment has finished.
Croatian: Razgovarajte s liječnikom PRIJE uzimanja CABOMETYXA ako Vi ili Vaša partnerica razmišljate ili planirate imati dijete nakon završetka liječenja.
English: There is no information on the precise food-effect when taken 1 hour after administration of cabozantinib.
Croatian: Ne postoje podaci o točnom učinku hrane uzete 1 sat nakon primjene kabozantiniba.
English: Fertility studies in rats have shown reduced male and female fertility.
Croatian: Ispitivanja plodnosti u štakora pokazala su smanjenu plodnost u mužjaka i ženki.
English: Tumor assessments were conducted every 12 weeks.
Croatian: Procjene tumora provođene su svakih 12 tjedana.
English: Partial responses
Croatian: Parcijalni odgovor
English: Your doctor may also prescribe other medicines to help control your side effects.
Croatian: Liječnik Vam također može propisati druge lijekove za kontrolu nuspojava.
English: The median time to first dose reduction was 55 days, and to first dose interruption was 38 days.
Croatian: Medijan vremena do prvog smanjenja doze iznosio je 55 dana, a do prvog prekida doziranja 38 dana.
English: Take the next dose at the normal time.
Croatian: Sljedeću dozu uzmite u uobičajeno vrijeme.
English: Non-disease specific quality of life (QoL) was assessed using the EuroQoL EQ-5D-5L.
Croatian: Quality of Life, QoL) koja nije specifična za bolest procijenjena je s pomoću instrumenta za mjerenje EuroQoL EQ-5D-5L.
English: Cabozantinib should not be used during pregnancy unless the clinical condition of the woman requires treatment with cabozantinib.
Croatian: Kabozantinib se ne smije primjenjivati tijekom trudnoće osim ako kliničko stanje žene ne zahtijeva liječenje kabozantinibom.
English: BATCH NUMBER<, DONATION AND PRODUCT CODES>
Croatian: 13. BROJ SERIJE<, OZNAKE DONACIJE I PROIZVODA> Serija
English: Aetiology for HCC included 38% hepatitis B virus (HBV), 21% hepatitis C virus (HCV), 40% other (neither HBV nor HCV).
Croatian: Etiologija za HCC uključivala je u 38 % virus hepatitisa B (HBV), 21 % virus hepatitisa C (HCV), 40 % drugo (ni HBV ni HCV).
English: Pharmacotherapeutic group: antineoplastic agent, protein kinase inhibitor, ATC code: L01XE26.
Croatian: Farmakoterapijska skupina: antineoplastici, inhibitori protein kinaze, ATK oznaka: L01XE26.
English: It is recommended to perform liver function tests (ALT, AST and bilirubin) before initiation of cabozantinib treatment and to monitor closely during treatment.
Croatian: Preporučuje se provođenje testova funkcije jetre (ALT, AST i bilirubin) prije uvođenja liječenja kabozantinibom i pažljivo praćenje tijekom liječenja.
English: These proteins can be present in high amounts in cancer cells, and by blocking their action CABOMETYX can slow down the rate at which the tumour grows and help to cut off the blood supply that the cancer needs.
Croatian: Ti proteini mogu biti prisutni u stanicama raka u velikim količinama i blokiranjem njihovog djelovanja CABOMETYX može usporiti brzinu rasta tumora i prekinuti opskrbu krvlju koju rak treba.
English: A negative effect of Cabometyx versus placebo on the EQ-5D utility index score was observed during the first weeks of treatment.
Croatian: Negativan učinak lijeka Cabometyx u usporedbi s placebom na rezultat indeksa korisnosti EQ-5D opažen je tijekom prvih tjedana liječenja.
English: Biochemical laboratory test abnormalities
Croatian: Abnormalnosti biokemijskih laboratorijskih testova
English: Treatment should continue until the patient is no longer clinically benefiting from therapy or until unacceptable toxicity occurs.
Croatian: Liječenje treba nastaviti sve dok bolesnik ima kliničku korist od terapije ili do pojave neprihvatljive toksičnosti.
English: Ipsen Portugal - Produtos Farmacêuticos S.A. Alameda Fernão Lopes, n° 16A - 1°B 1495 - 190 Algés
Croatian: Ipsen Portugal - Produtos Farmacêuticos S.A. Alameda Fernão Lopes, n° 16A-1°B Miraflores P-1495 - 190 Algés Portugal
English: Embryo-foetal development studies were performed in rats and rabbits.
Croatian: Provedena su ispitivanja embriofetalnog razvoja u štakora i kunića.
English: Patients should be instructed to not eat anything for at least 2 hours before through 1 hour after taking CABOMETYX.
Croatian: Bolesnike treba uputiti da ništa ne jedu najmanje 2 sata prije i jedan sat poslije uzimanja CABOMETYXA.
English: A population PK analysis did not identify clinically relevant differences in PK of cabozantinib based on race.
Croatian: Populacijska PK analiza nije otkrila klinički značajne razlike u PK kabozantiniba na temelju rase.
English: These may be signs of a gastrointestinal perforation, a hole that develops in your stomach or intestine that could be life-threatening.
Croatian: To mogu biti znakovi perforacije u probavnom sustavu, puknuća koje nastane u želucu ili crijevima i može biti opasno po život.
English: Cabozantinib is highly protein bound in vitro in human plasma (≥ 99.7%).
Croatian: Kabozantinib se in vitro izrazito veže za proteine u ljudskoj plazmi (≥ 99,7 %).
English: Since only limited data are available for patients with moderate hepatic impairment (Child Pugh B), no dosing recommendation can be provided.
Croatian: Budući da su dostupni samo ograničeni podaci za bolesnike s umjerenim oštećenjem funkcije jetre (Child Pugh B), nije moguće dati preporuke o doziranju.
English: • Anaemia (low levels of red blood cells)
Croatian: • Anemija (niska razina crvenih krvnih stanica)
English: Adverse reactions not observed in clinical studies, but seen in animals at exposure levels similar to clinical exposure levels and with possible relevance to clinical use were as follows:
Croatian: Nuspojave koje nisu zabilježene u kliničkim ispitivanjima, ali su zapažene u životinja pri razinama izloženosti sličnima razinama kliničke izloženosti u ljudi i s mogućom važnošću za kliničku primjenu, bile su sljedeće:
English: Also, some medicines can affect the way CABOMETYX works.
Croatian: Također, neki lijekovi mogu utjecati na način djelovanja CABOMETYXA.
English: Grade 2 adverse reactions which are intolerable and cannot be managed with a dose reduction or supportive care
Croatian: 2. stupanj nuspojava koje su nepodnošljive i ne mogu se zbrinuti smanjenjem doze ili potpornim mjerama.
English: Patients were stratified by IMDC risk group and presence of bone metastases (yes/no).
Croatian: Bolesnici su stratificirani prema IMDC skupinama rizika i prisutnosti metastaza kostiju (da/ne).