FrancophonIA/ELRC3.0 huggingface dataset:
English: Apixaban also demonstrates anti-FXa activity as evident by reduction in Factor Xa enzyme activity in multiple commercial anti-FXa kits, however results differ across kits.
Croatian: Apiksaban također pokazuje anti-FXa aktivnost, što se vidi u smanjenju aktivnosti enzima faktora Xa u mnogobrojnim komercijalno dostupnim testovima anti-FXa aktivnosti, no ti se rezultati razlikuju među testovima.
English: Changes observed in these clotting tests at the expected therapeutic dose are small and subject to a high degree of variability.
Croatian: Promjene uočene u navedenim testovima zgrušavanja pri očekivanoj terapijskoj dozi su male i podložne visokom stupnju varijabilnosti.
English: After an operation to the hip or knee you may be at a higher risk of developing blood clots in your leg veins.
Croatian: Nakon operacije na kuku ili koljenu može postojati povećan rizik od nastanka krvnih ugrušaka u venama nogu.
English: The first dose of apixaban was given 12 to 24 hours post-surgery, whereas enoxaparin was started 9 to 15 hours prior to surgery.
Croatian: Prva doza apiksabana primijenjena je 12 do 24 sata nakon kirurškog zahvata, dok je primjena enoksaparina započela 9 do 15 sati prije kirurškog zahvata.
English: What you need to know before you take Eliquis
Croatian: Što morate znati prije nego počnete uzimati Eliquis
English: • prior stroke or transient ischaemic attack (TIA)
Croatian: • pretrpljen moždani udar ili tranzitorna ishemijska ataka (TIA)
English: * Assessed by sequential testing strategy designed to control the overall type I error in the trial.
Croatian: * Procijenjeno strategijom sekvencijskoga ispitivanja osmišljenoga s ciljem kontroliranja ukupne pojavnosti pogreške tipa
English: This risk of bleeding should be weighed against the urgency of intervention.
Croatian: Potrebno je procijeniti rizik od krvarenja u odnosu na hitnost interventnog zahvata.
English: The major observed effects in the repeated dose toxicity studies were those related to the pharmacodynamic action of apixaban on blood coagulation parameters.
Croatian: Najvažniji učinci opaženi u ispitivanjima toksičnosti ponovljenih doza povezani su s farmakodinamičkom aktivnošću apiksabana na parametre zgrušavanja krvi.
English: If you take more Eliquis than you should
Croatian: Ako uzmete više lijeka Eliquis nego što ste trebali
English: If you need surgery, inform your doctor that you are taking Eliquis.
Croatian: • Ako idete na operaciju, obavijestite svog liječnika da uzimate Eliquis.
English: Elderly patients (above 65 years) exhibited higher plasma concentrations than younger patients, with mean AUC values being approximately 32% higher and no difference in Cmax.
Croatian: U starijih su bolesnika (stariji od 65 godina) zabilježene više koncentracije u plazmi nego u mlađih bolesnika, pri čemu su vrijednosti AUC-a bile otprilike 32% više, dok se vrijednost Cmax nije mijenjala.
English: The initial dose should be taken 12 to 24 hours after surgery.
Croatian: Početnu dozu treba uzeti 12 do 24 sata nakon kirurškog zahvata.
English: Total VTE/all-cause death Number of events/subjects Event Rate
Croatian: Ukupan broj VTE/smrti zbog bilo kojega razloga Broj događaja/ispitanika
English: They are not recommended to assess the pharmacodynamic effects of apixaban.
Croatian: Ne preporučuju se za procjenu farmakodinamičkih učinaka apiksabana.
English: Apixaban is metabolised mainly via CYP3A4/5 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2.
Croatian: Apiksaban se metabolizira prvenstveno putem CYP3A4/5, uz manji doprinos CYP1A2, 2C8, 2C9, 2C19 i 2J2.
English: Prior to initiating Eliquis, liver function testing should be performed.
Croatian: Prije početka liječenja lijekom Eliquis treba provesti testove jetrene funkcije.
English: The risk may also be increased by traumatic or repeated epidural or spinal puncture.
Croatian: Rizik također mogu povećati traumatske ili opetovne epiduralne ili spinalne punkcije.
English: NVAF - No dose adjustment required, unless criteria for dose reduction are met (see Dose reduction at the beginning of section 4.2).
Croatian: NVAF - Nije potrebno prilagođavati dozu, osim ako su zadovoljeni kriteriji za smanjenje doze (vidjeti Smanjenje doze na početku dijela 4.2).
English: Eliquis should be restarted after the invasive procedure or surgical intervention as soon as possible provided the clinical situation allows and adequate haemostasis has been established (for cardioversion see section 4.2).
Croatian: Eliquis se mora početi ponovno uzimati što je prije moguće nakon invazivnog postupka ili kirurškog zahvata, ako to dopušta klinička situacija i ako je uspostavljena adekvatna hemostaza (za kardioverziju vidjeti dio 4.2).
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Eliquis in one or more subsets of the paediatric population in venous and arterial embolism and thrombosis (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Eliquis u jednoj ili više podskupina pedijatrijske populacije u venskoj i arterijskoj emboliji i trombozi (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: Table 5: Bleeding Results from Pivotal Phase III Studies* ADVANCE-3
Croatian: Tablica 5: Rezultati krvarenja iz pivotalnih ispitivanja faze III* ADVANCE-3
English: Take Eliquis as recommended for the following:
Croatian: Uzimajte Eliquis prema preporuci liječnika za:
English: The administration of the loading dose should be given at least 2 hours before cardioversion (see section 5.1).
Croatian: Udarna doza treba biti primijenjena najmanje 2 sata prije kardioverzije (vidjeti dio 5.1).
English: Number of events/subjects Event Rate
Croatian: Broj događaja/ispitanika
English: The use of Eliquis may be associated with an increased risk of occult or overt bleeding from any tissue or organ, which may result in posthaemorrhagic anaemia.
Croatian: Primjena lijeka Eliquis može biti povezana s povećanim rizikom od okultnog ili vidljivog krvarenja iz bilo kojeg tkiva ili organa, što može prouzročiti posthemoragijsku anemiju.
English: Therefore, the use of Eliquis is not recommended in this setting.
Croatian: Stoga se ne preporučuje primjenjivati Eliquis u ovom stanju.
English: Discontinuing anticoagulants, including Eliquis, for active bleeding, elective surgery, or invasive procedures places patients at an increased risk of thrombosis.
Croatian: Prekid liječenja antikoagulansima, uključujući Eliquis, zbog aktivnog krvarenja, elektivnog kirurškog zahvata ili invazivnih postupaka u bolesnika povećava rizik od tromboze.
English: In case of major bleeding events, it should be stopped immediately.
Croatian: U slučajevima jakih krvarenja, potrebno je odmah prekinuti primjenu.
English: Eliquis is not recommended as an alternative to unfractionated heparin in patients with pulmonary embolism who are haemodynamically unstable or may receive thrombolysis or pulmonary embolectomy since the safety and efficacy of apixaban have not been established in these clinical situations.
Croatian: Eliquis se ne preporučuje kao alternativa nefrakcioniranom heparinu u bolesnika s plućnom embolijom koji su hemodinamski nestabilni ili u kojih bi se mogla primijeniti tromboliza ili plućna embolektomija, jer sigurnost i djelotvornost apiksabana nisu ustanovljene u tim kliničkim situacijama.
English: You should keep this card with you at all times.
Croatian: Karticu trebate uvijek imati sa sobom.
English: Separate your language as needed (this is facilitated by the perforated edges)
Croatian: Izdvojite karticu na Vašem jeziku (radnju olakšavaju probušeni rubovi)
English: Patients are to be frequently monitored for signs and symptoms of neurological impairment (e.g., numbness or weakness of the legs, bowel or bladder dysfunction).
Croatian: Bolesnike treba često kontrolirati zbog moguće pojave znakova neurološkog oštećenja (npr. utrnulost ili slabost u nogama, disfunkcija crijeva ili mjehura).
English: - Anaemia which may cause tiredness or paleness - Bleeding including:
Croatian: - Anemija koja može izazvati umor ili bljedoću - Krvarenje koje uključuje:
English: Patients were exposed to study drug for a mean of 14 months.
Croatian: Bolesnici su bili izloženi ispitivanom lijeku u prosjeku 14 mjeseci.
English: With improving monitoring of INR the observed benefits of apixaban compared to warfarin regarding all cause death diminish.
Croatian: Uz poboljšano praćenje INR-a smanjuju se opažene prednosti apiksabana u odnosu na varfarin što se tiče smrti zbog bilo kojeg razloga.
English: As with all new anticoagulant medicinal products, experience with neuraxial blockade is limited and extreme caution is therefore recommended when using apixaban in the presence of neuraxial blockade.
Croatian: Kao i kod svih novih antikoagulansa, iskustvo s neuroaksijalnom blokadom je ograničeno i stoga je potreban izniman oprez kod primjene apiksabana uz neuroaksijalnu blokadu.
English: Findings from a population pharmacokinetic analysis in patients who received apixaban were generally consistent with the phase I results.
Croatian: Rezultati populacijske farmakokinetičke analize u bolesnika koji su primali apiksaban uglavnom su se podudarali s rezultatima ispitivanja faze I.
English: Injury, poisoning and procedural complications Contusion
Croatian: Ozljede, trovanja i proceduralne komplikacije Kontuzija često često
English: A decision must be made to either discontinue breast-feeding or to discontinue/abstain from apixaban therapy.
Croatian: Nužno je odlučiti da li prekinuti dojenje ili prekinuti/suzdržati se od liječenja apiksabanom.
English: Switching treatment from parenteral anticoagulants to Eliquis (and vice versa) can be done at the next scheduled dose (see section 4.5).
Croatian: Prelazak s liječenja parenteralnim antikoagulansima na Eliquis (i obrnuto) može se izvršiti kod primjene sljedeće doze po rasporedu (vidjeti dio 4.5).
English: Safety and efficacy of Eliquis have not been studied in patients with prosthetic heart valves, with or without atrial fibrillation.
Croatian: Sigurnost i djelotvornost lijeka Eliquis nisu ispitivane u bolesnika s protetskim srčanim zaliscima, sa ili bez fibrilacije atrija.
English: Eliquis has no or negligible influence on the ability to drive and use machines.
Croatian: Eliquis ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: If you take more Eliquis than recommended, you may have an increased risk of bleeding.
Croatian: Ako uzmete više lijeka Eliquis nego što ste trebali, može postojati povećan rizik od krvarenja.
English: Eliquis may increase the risk of bleeding.
Croatian: • Eliquis može povećati rizik od krvarenja.
English: All-cause death
Croatian: Ukupna smrtnost
English: Based on patient medical history in the studied population of ADVANCE-3 and ADVANCE-2 (8,464 patients), 46% had hypertension, 10% had hyperlipidemia, 9% had diabetes, and 8% had coronary artery disease.
Croatian: Na temelju anamneze bolesnika, u ispitivanoj populaciji u sklopu ispitivanja ADVANCE-3 i ADVANCE-2 (8464 bolesnika) 46% bolesnika je imalo hipertenziju, 10% hiperlipidemiju, 9% šećernu bolest i 8% koronarnu bolest srca.
English: Patient Alert Card: handling information
Croatian: Kartica s upozorenjima za bolesnika: rukovanje informacijama
English: The next dose of apixaban may be given at least 5 hours after catheter removal.
Croatian: Sljedeća doza apiksabana smije se dati najranije 5 sati nakon uklanjanja katetera.
English: In the apixaban group, 342 patients received a loading dose (331 patients received the 10 mg dose and 11 patients received the 5 mg dose).
Croatian: U skupini liječenoj apiksabanom udarnu dozu primila su 342 bolesnika (331 bolesnik je primio dozu od 10 mg, a 11 bolesnika dozu od 5 mg).
English: Post-surgery treatment period Major
Croatian: Vrijeme liječenja nakon kirurškog zahvata Značajna
English: Decisions on initiation and duration of treatment should take established guideline recommendations for anticoagulant treatment in patients undergoing cardioversion into account.
Croatian: Pri donošenju odluka o početku i trajanju liječenja treba uzeti u obzir preporuke važećih smjernica za antikoagulacijsko liječenje bolesnika koji se podvrgavaju kardioverziji.
English: Cmin (ng/mL)
Croatian: Apiksaban Cmin (ng/ml)
English: Fertility Studies in animals dosed with apixaban have shown no effect on fertility (see section 5.3).
Croatian: Ispitivanja u životinja koje su dobile dozu apiksabana nisu pokazala štetne učinke na plodnost (vidjeti dio 5.3).
English: In the absence of other criteria for dose reduction (age, body weight), no dose adjustment is necessary (see section 5.2).
Croatian: U odsutnosti drugih kriterija za smanjenje doze (dob, tjelesna težina), nije potrebno prilagođavati dozu (vidjeti dio 5.2).
English: Patients undergoing cardioversion Apixaban can be initiated or continued in NVAF patients who may require cardioversion.
Croatian: S primjenom apiksabana može se započeti ili nastaviti u bolesnika s NVAF-om kojima bi mogla biti potrebna kardioverzija.
English: Administration of prothrombin complex concentrates (PCCs) or recombinant factor VIIa may also be considered.
Croatian: Potrebno je razmotriti i primjenu koncentrata protrombinskog kompleksa (PCC-ova) ili rekombinantnog faktora VIIa.
English: * There were no occurrences of generalized pruritus in CV185057 (long term prevention of VTE) † The term “Brain haemorrhage” encompasses all intracranial or intraspinal haemorrhages (ie., haemorrhagic stroke or putamen, cerebellar, intraventricular, or subdural haemorrhages).
Croatian: * Nije bilo pojava generaliziranog pruritusa u CV185057 (dugoročna prevencija VTE-a) Pojam „krvarenje u mozgu“ obuhvaća sva intrakranijalna ili intraspinalna krvarenja (tj. hemoragijski moždani udar ili krvarenja u putamenu, cerebelumu, intraventrikularna ili subduralna krvarenja).
English: The safety and efficacy of Eliquis in children and adolescents below age 18 have not been established.
Croatian: Sigurnost i djelotvornost lijeka Eliquis u djece i adolescenata mlađih od 18 godina nisu ustanovljene.
English: Preclinical studies of apixaban in animal models have demonstrated antithrombotic efficacy in the prevention of arterial and venous thrombosis at doses that preserved haemostasis.
Croatian: Neklinička ispitivanja apiksabana na životinjskim modelima pokazala su antitrombotsku djelotvornost u prevenciji arterijske i venske tromboze u dozama kod kojih je očuvana hemostaza.
English: In patients with atrial fibrillation and conditions that warrant mono or dual antiplatelet therapy, a careful assessment of the potential benefits against the potential risks should be made before combining this therapy with Eliquis.
Croatian: U bolesnika s fibrilacijom atrija i stanjima koja iziskuju monoterapiju ili dvojnu terapiju antitrombocitnim lijekovima potrebno je provesti pažljivu procjenu potencijalnih koristi i potencijalnih rizika prije kombiniranja takve terapije s lijekom Eliquis.
English: They will advise you to either stop breastfeeding or to stop/not start taking Eliquis.
Croatian: Preporučit će Vam da prestanete dojiti ili da prestanete/ne počinjete uzimati Eliquis.
English: Reversal of Eliquis pharmacodynamic effects, as demonstrated by changes in the thrombin generation assay, was evident at the end of infusion and reached baseline values within 4 hours after the start of a 4-factor PCC 30 minute infusion in healthy subjects.
Croatian: Poništenje farmakodinamičkog učinka lijeka Eliquis, kako je pokazano promjenama u testu stvaranja trombina, bilo je vidljivo je na kraju infuzije i doseglo je početne vrijednosti u roku od 4 sata nakon početka 30-minutne infuzije 4-faktorskog PCC-a u zdravih ispitanika.
English: Table 4: Efficacy Results from Pivotal Phase III Studies Study
Croatian: Tablica 4: Rezultati djelotvornosti iz pivotalnih ispitivanja faze III Ispitivanje
English: Prevention of recurrent DVT and/or PE following completion of 6 months of treatment for DVT or PE
Croatian: Prevencija ponavljajućih DVT i/ili PE nakon dovršetka 6-mjesečnog liječenja DVT ili PE
English: As with other anticoagulants, patients taking Eliquis are to be carefully observed for signs of bleeding.
Croatian: Kao i kod primjene drugih antikoagulansa, bolesnike koji uzimaju Eliquis treba pomno motriti kako bi se uočili znakovi krvarenja.
English: Apixaban has a total clearance of about 3.3 L/h and a half-life of approximately 12 hours.
Croatian: Ukupni klirens apiksabana iznosi 3,3 l/h, a poluvijek mu je približno 12 sati.
English: It is unknown whether apixaban or its metabolites are excreted in human milk.
Croatian: Nije poznato izlučuju li se apiksaban ili njegovi metaboliti u majčino mlijeko u ljudi.
English: Prevention of stroke and systemic embolism: NVAF 2.5 mg twice daily*
Croatian: Prevencija moždanog udara i sistemske embolije: NVAF 2,5 mg dva puta na dan *
English: * Major bleeding defined per International Society on Thrombosis and Haemostasis (ISTH) criteria.
Croatian: *Veliko krvarenje definirano prema kriterijima Međunarodnog društva za trombozu i hemostazu (ISTH).
English: Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake „Rok valjanosti“/ „EXP“.
English: Activated charcoal Administration of activated charcoal reduces apixaban exposure (see section 4.9).
Croatian: Primjena aktivnog ugljena umanjuje izloženost apiksabanu (vidjeti dio 4.9).
English: This Patient Alert Card includes information that will be helpful to you and alert other doctors that you are taking Eliquis.
Croatian: Kartica s upozorenjima za bolesnika navodi informacije koje će Vama biti korisne a druge liječnike će upozoriti da uzimate Eliquis.
English: If your abnormal heartbeat needs to be restored to normal by a procedure called cardioversion, take Eliquis at the times your doctor tells you, to prevent blood clots in blood vessels in your brain and other blood vessels in your body.
Croatian: Ako Vam je potrebno normalizirati poremećene otkucaje srca postupkom koji se naziva kardioverzija, uzimajte lijek Eliquis u razmacima koje je odredio liječnik kako biste spriječili stvaranje krvnih ugrušaka u krvnim žilama u mozgu i drugim krvnim žilama u tijelu.
English: Changes in anti-Factor Xa activity and INR were comparable between subjects with mild to moderate hepatic impairment and healthy subjects.
Croatian: Promjene anti-FXa aktivnosti i INR-a bile su usporedive u ispitanika s blagim do umjerenim oštećenjem jetrene funkcije i zdravih ispitanika.
English: Inside the Eliquis pack together with the package leaflet you will find a Patient Alert Card or your doctor might give you a similar card.
Croatian: U pakiranju lijeka Eliquis zajedno s Uputom o lijeku nalazi se Kartica s upozorenjima za bolesnika ili će Vam liječnik dati sličnu karticu.
English: Eliquis contains lactose.
Croatian: Eliquis sadrži laktozu.
English: I am under anticoagulation treatment with Eliquis (apixaban) to prevent blood clots
Croatian: Liječim se antikoagulacijskim lijekom Eliquis (apiksaban) koji sprječava zgrušavanje krvi
English: • Signs or symptoms of bleeding and when to seek attention from a health care provider.
Croatian: • Znakovi i simptomi krvarenja te kada bolesnik mora potražiti pomoć zdravstvenog radnika.
English: In case there is such need and based on the general PK characteristics of apixaban, a time interval of 20-30 hours (i.e., 2 x half-life) between the last dose of apixaban and catheter withdrawal should elapse, and at least one dose should be omitted before catheter withdrawal.
Croatian: Ako za time postoji potreba, a na temelju općih farmakokinetičkih svojstava apiksabana, između posljednje doze apiksabana i uklanjanja katetera treba proći 20-30 sati (tj. 2 poluvijeka) i prije uklanjanja katetera treba preskočiti barem jednu dozu.
English: This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially "sodiumfree".
Croatian: Ovaj lijek sadrži manje od 1 mmol natrija (23 mg) po tableti, tj. zanemarive količine natrija.
English: In patients undergoing hip replacement surgery The recommended duration of treatment is 32 to 38 days.
Croatian: U bolesnika podvrgnutih kirurškom zahvatu ugradnje endoproteze kuka Preporučeno trajanje liječenja je 32 do 38 dana.
English: EMANATE, an open-label, multi-center study, enrolled 1500 patients who were either oral anticoagulant naïve or pre-treated less than 48 hours, and scheduled for cardioversion for NVAF.
Croatian: Otvoreno, multicentrično ispitivanje EMANATE uključivalo je 1500 bolesnika koji prethodno nisu bili liječeni peroralnim antikoagulansima ili su njima prethodno bili liječeni kraće od 48 sati, te za koje je planirana kardioverzija zbog NVAF-a.
English: In patients undergoing knee replacement surgery The recommended duration of treatment is 10 to 14 days.
Croatian: U bolesnika podvrgnutih kirurškom zahvatu ugradnje endoproteze koljena Preporučeno trajanje liječenja je 10 do 14 dana.
English: Direct acting Oral Anticoagulants (DOACs) including apixaban are not recommended for patients with a history of thrombosis who are diagnosed with antiphospholipid syndrome.
Croatian: Direktno djelujući oralni antikoagulansi (engl. direct acting oral anticoagulants, DOAC), uključujući apiksaban, ne preporučuju se bolesnicima koji u anamnezi imaju trombozu a dijagnosticiran im je antifosfolipidni sindrom.
English: Relative Risk (95% CI)
Croatian: Relativan rizik (95% CI)
English: The mean age was 56.9 years and 89.8% of randomised patients had unprovoked VTE events.
Croatian: Prosječna dob bila je 56,9 godina i 89,8% randomiziranih bolesnika imalo je neizazvane VTE.
English: The primary safety endpoint was major bleeding.
Croatian: Primarni sigurnosni ishod bilo je veliko krvarenje.
English: The pharmacokinetic /pharmacodynamic (PK/PD) relationship between apixaban plasma concentration and several PD endpoints (anti-FXa activity, INR, PT, aPTT) has been evaluated after administration of a wide range of doses (0.5 - 50 mg).
Croatian: Ocijenjen je farmakokinetički/farmakodinamički (PK/PD) odnos između koncentracije apiksabana u plazmi i nekoliko farmakodinamičkih mjera ishoda (anti-FXa aktivnost, INR, PV, aPTV) nakon primjene širokog raspona doza (0,5 mg - 50 mg).
English: In patients receiving concomitant systemic treatment with strong inducers of both CYP3A4 and P-gp the following recommendations apply (see section 4.5):
Croatian: U bolesnika koji istodobno primaju sistemsku terapiju snažnim induktorima CYP3A4 i P-gp primjenjuju se sljedeće preporuke (vidjeti dio 4.5):
English: Apixaban efficacy for prevention of a recurrence of a VTE was maintained across subgroups, including age, gender, BMI, and renal function.
Croatian: Djelotvornost apiksabana u prevenciji ponavljajućeg venskog tromboembolijskog događaja održana je u podskupinama, uključujući dob, spol, BMI i bubrežnu funkciju.
English: Increases in clotting tests (PT, INR, and aPTT) were consistent with the effects of apixaban alone.
Croatian: Promjene rezultata testova zgrušavanja (PV, INR i aPTV) bile su konzistentne s učincima apiksabana primijenjenog samostalno.
English: If a blood clot travels from your leg to your lungs, it can block blood flow causing breathlessness, with or without chest pain.
Croatian: Ako krvni ugrušak iz noge dospije u pluća, može blokirati protok krvi i prouzročiti nedostatak zraka, koji može ili ne mora biti popraćen bolovima u prsima.
English: In this clinical trial, there was limited (2.1%) use of concomitant dual antiplatelet therapy.
Croatian: U ovom je kliničkom ispitivanju istodobno primjenjivano dvojno antitrombocitno liječenje u ograničenoj mjeri (2,1%).
English: All the bleeding criteria included surgical site bleeding.
Croatian: Svi kriteriji za krvarenje uključuju krvarenje na mjestu kirurškog zahvata.
English: There are no data from the use of apixaban in pregnant women.
Croatian: Nema podataka o primjeni apiksabana u trudnica.
English: Therefore Eliquis should be used cautiously in this population (see section 5.2).
Croatian: Stoga se u navedenoj populaciji Eliquis treba primjenjivati uz oprez (vidjeti dio 5.2).