FrancophonIA/ELRC3.0 huggingface dataset:
English: For adults whose body weight is 30 kg or more, the usual starting dose is 30 or 40 mg given twice daily (with approximately 12 hours between each dose).
Croatian: Za odrasle čija tjelesna težina iznosi 30 kg i više, uobičajena početna doza je 30 ili 40 mg dva puta dnevno (s razmakom od otprilike 12 sati između doza).
English: Early symptoms (symptomatic hyperlactatemia) include benign digestive symptoms (nausea, vomiting and abdominal pain), non-specific malaise, loss of appetite, weight loss, respiratory symptoms (rapid and/or deep breathing) or neurological symptoms (including motor weakness).
Croatian: Rani simptomi (simptomatska hiperlaktemija) uključuju benigne probavne simptome (mučnina, povraćanje i bol u abdomenu), nespecifično opće loše stanje, gubitak apetita, gubitak tjelesne težine, respiratorne simptome (brzo i/ili duboko disanje) ili neurološke simptome (uključujući motornu slabost).
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajima intolerancije fruktoze, malapsorpcijom glukoze igalaktoze ili insuficijencijom saharazeizomaltaze, ne smiju uzimati ovaj lijek.
English: The capsule shells are marked using edible black printing ink containing shellac, propylene glycol, purified water, potassium hydroxide and iron oxide (E172).
Croatian: Ovojnica kapsule je označena jestivom crnom tintom za označavanje koja sadrži šelak, propilenglikol, pročišćenu vodu, kalijev hidroksid i željezov oksid (E172).
English: The therapy should be initiated by a doctor experienced in the management of HIV infection (see also section 4.4).
Croatian: Terapiju treba započeti primjenjivati liječnik koji ima iskustva u liječenju HIV infekcija (vidjeti i dio
English: Following an oral 80-mg dose of 14C-stavudine to healthy subjects, approximately 95% and 3% of the total radioactivity was recovered in urine and faeces, respectively.
Croatian: Nakon oralne primjene 80 mg 14C-stavudina u zdravih ispitanika otprilike se 95% ukupne radioaktivosti otkrilo u mokraći i 3% u stolici.
English: Zerit 15 mg hard capsules Zerit 20 mg hard capsules Zerit 30 mg hard capsules Zerit 40 mg hard capsules
Croatian: Zerit 15 mg tvrde kapsule Zerit 20 mg tvrde kapsule Zerit 30 mg tvrde kapsule
English: 30 mg twice daily (every 12 hours) 40 mg twice daily (every 12 hours)
Croatian: 30 mg dva puta dnevno (svakih 12 sati) 40 mg dva puta dnevno (svakih 12 sati)
English: Zerit 200 mg powder for oral solution is supplied in a bottle containing 200 ml solution.
Croatian: Zerit 200 mg prašak za oralnu otopinu dostupan je u boci za 200 ml otopine.
English: Each bottle contains 200 mg of stavudine.
Croatian: Jedna boca sadrži 200 mg stavudina.
English: Immune reactivation syndrome: in HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: Sindrom imunološke reaktivacije: u bolesnika inficiranih virusom HIV-a, s teškim imunološkim deficitom u trenutku uvođenja kombinacijske antiretrovirusne terapije (CART), može doći do upalne reakcije na asimptomatske ili rezidualne oportunističke infekcije.
English: Laboratory abnormalities: laboratory abnormalities reported in these two trials and an ongoing follow-up study included elevations of ALT (> 5 x ULN) in 3%, of AST (> 5 x ULN) in 3%, of lipase (≥ 2.1 ULN) in 3% of the patients in the Zerit group.
Croatian: Abnormalnosti u laboratorijskim nalazima: abnormalnosti u laboratorijskim nalazima opisana u navedena dva ispitivanja i studijama praćenja, a uključivala su porast ALT (> 5 x Gornje Granice Normale) u 3% bolesnika, ALT (> 5 x GGN) u 3% bolesnika i lipaze (> 2,1 GGN) u 3% bolesnika u skupini s lijekom Zerit.
English: Preliminary safety data from this study (see also section 4.8), showed an increased infant mortality in the stavudine + didanosine (10%) treatment group compared to the stavudine (2%), didanosine (3%) or zidovudine (6%) groups, with a higher incidence of stillbirths in the stavudine + didanosine group.
Croatian: Preliminarni podaci o sigurnosti iz ovog ispitivanja (vidjeti dio 4.8) pokazali su povećanu smrtnost dojenčadi u skupini liječenoj sa stavudinom + didanozinom (10%), u usporedbi sa skupinama liječenim stavudinom (2%), didanozinom (3%) ili zidovudinom (6%), kao i veću učestalost mrtvorođene djece u skupini sa stavudinom + didanozinom.
English: HDPE bottle with child resistant screw cap, fill mark (200 ml of solution after reconstitution) and measuring cup.
Croatian: HDPE boca sa sigurnosnim zatvaračem za djecu s navojem, oznakom na boci (200 ml otopine nakonrekonstitucije ) i odmjernom čašicom.
English: Preclinical studies showed placental transfer of stavudine (see section 5.3).
Croatian: Preklinička ispitivanja pokazala su prolazak stavudina kroz posteljicu (vidjeti dio 5.3).
English: During therapy with Zerit there is often a gradual loss of subcutaneous fat (fat found beneath the skin), which is most notable in the face and on the legs and arms.
Croatian: Tijekom terapije lijekom Zerit često je prisutan postupan gubitak potkožnog masnog tkiva (masno tkivo koje se nalazi ispod kože), koji je najizraženiji na licu i u nogama i rukama.
English: The reconstituted solution contains 1 mg of stavudine per ml.
Croatian: Rekonstituirana otopina sadrži 1 mg stavudina po ml.
English: rare: anaemia* very rare: neutropenia*, thrombocytopenia*
Croatian: rijetko: anemija * vrlo rijetko: neutropenija *, trombocitopenija *
English: uncommon: hepatitis or jaundice rare: hepatic steatosis* very rare: liver failure*
Croatian: manje često: hepatitis ili žutica rijetko: steatoza jetre * vrlo rijetko: zatajenje jetre*
English: A study in asymptomatic patients demonstrated that systemic exposure is similar while Cmax is lower and Tmax is prolonged when stavudine is administered with a standardised, high-fat meal compared with fasting conditions.
Croatian: Ispitivanje na asimptomatskim bolesnicima je pokazalo da, u usporedbi s primjenom natašte, kada se stavudin primjenjuje uz standardizirani obrok bogat mastima, sistemska izloženost je slična, dok je Cmax niži, a Tmax produžen.
English: In the stavudine containing arms, the neonates were treated for 6 weeks with stavudine 1 mg/kg BID.
Croatian: U kraku ispitivanja koje je uključilo stavudin, novorođenčad je liječena stavudinom kroz 6 tjedana s 1 mg/kg dva puta dnevno.
English: After reconstitution with water, the solution contains 50 mg of sucrose per ml of solution.
Croatian: Nakon pripreme otopine s vodom, otopina sadrži 50 mg saharoze po ml otopine.
English: Zerit may cause dizziness and drowsiness.
Croatian: Zerit može uzrokovati omaglicu i omamljenost.
English: (range 63 to 962 cells/mm3) and a median plasma HIV-1 RNA of 4.63 log10 copies/ml (range 3.0 to 5.9 log10 copies/ml) at baseline.
Croatian: (raspon od 63 do 962 stanica/mm 3) i početnim medijanom vrijednosti HIV-1 RNA u plazmi od 4,63 log10 kopija/ml (raspon 3,0 do 5,9 log10 kopija/ml).
English: No studies on the effects on the ability to drive and use machines have been performed.
Croatian: Ispitivanja utjecaja na sposobnost upravljanja vozilima i rada na strojevima nisu se provodila.
English: Stavudine was carcinogenic in mice (liver tumours) and rats (liver tumours: cholangiocellular, hepatocellular, mixed hepatocholangiocellular, and/or vascular; and urinary bladder carcinomas) at very high exposure levels.
Croatian: Kod visokih razina izloženosti, stavudin je bio karcinogen za miševe (tumori jetre) i štakore (tumori jetre: kolangiocelularni, hepatocelularni, mješoviti hepatokolangiocelularni, i/ili vaskularni; te karcinomi mokraćnog mjehura).
English: The total clearance of stavudine appears to be higher in HIV-infected patients, while the renal clearance is similar between healthy subjects and HIV-infected patients.
Croatian: Ukupni klirens stavudina čini se većim u bolesnika inficiranih HIV-om, dok je bubrežni klirens sličan onome u zdravih ispitanika.
English: C-stavudine to healthy subjects, approximately 95% and 3% of the total radioactivity was recovered in urine and faeces, respectively.
Croatian: C-stavudina u zdravih ispitanika otprilike se 95% ukupne radioaktivosti otkrilo u mokraći i 3% u stolici.
English: Zerit belongs to a particular group of antiviral medicines, also known as antiretrovirals, called nucleoside reverse transcriptase inhibitors (NRTIs).
Croatian: Zerit pripada posebnoj skupini antivirusnih lijekova, poznatih kao antiretrovirusni lijekovi, zvani nukleozidni inhibitori reverzne transkriptaze (NRTI).
English: 15 mg every 24 hours
Croatian: 15 mg svakih 24 sata
English: Given the potential risks of using Zerit including lipoatrophy, a benefit-risk assessment for each patient should be made and an alternative antiretroviral carefully considered.
Croatian: S obzirom na moguće rizike primjene lijeka Zerit, uključujući lipoatrofiju, potrebno je procijeniti omjer koristi i rizika u svakog bolesnika posebno i pažljivo razmotriti alternativne mogućnosti antiretrovirusne terapije.
English: common: peripheral neurologic symptoms including peripheral neuropathy, paresthesia, and peripheral neuritis; dizziness; abnormal dreams; headache, insomnia; abnormal thinking; somnolence very rare: motor weakness* (most often reported in the setting of symptomatic hyperlactatemia or lactic acidosis syndrome)
Croatian: često: periferni neurološki simptomi koji uključuju perifernu neuropatiju, parestezije, i periferni neuritis; omaglica; abnormalni snovi; glavobolja, nesanica; abnormalne misli; somnolencija vrlo rijetko: motorička slabost * (najčešće zabilježena u okviru simptomatske hiperlaktatemije ili sindroma laktične acidoze)
English: Children at least 14 days old whose body weight is less than 30 kg, should receive 1 mg/kg twice daily.
Croatian: Djeca starosti najmanje 14 dana čija tjelesna težina je manja od 30 kg, trebaju primiti 1 mg/kg dva puta na dan.
English: In randomized controlled trials of treatment-naive patients, clinical lipoatrophy developed in a higher proportion of patients treated with stavudine compared to other nucleosides (tenofovir or abacavir).
Croatian: U randomiziranim kontroliranim ispitivanjima u prethodno neliječenih bolesnika, klinička lipoatrofija razvila se u većem postotku bolesnika liječenih stavudinom nego u onih liječenih drugim nukleozidima (tenofovir ili abakavir).
English: V75T is selected in vitro by stavudine and reduces susceptibility to stavudine by 2-fold.
Croatian: Stavudin in vitro selektira V75T, koja dvostruko smanjuje osjetljivost na stavudin.
English: To obtain optimal absorption, the capsules should be swallowed with a glass of water, preferentially at least one hour before a meal and on an empty stomach.
Croatian: Kako bi se postigla optimalna apsorpcija, kapsule treba progutati s čašom vode, preporučljivo najmanje jedan sat prije obroka i na prazan želudac.
English: common: diarrhoea, abdominal pain, nausea, dyspepsia uncommon: pancreatitis, vomiting
Croatian: često: proljev, bolovi u abdomenu, mučnina, dispepsija manje često: pankreatitis, povraćanje
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu/.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskojstranici Europske agencije za lijekove: http://www.ema.europa.eu/.
English: Immune reactivation syndrome: in HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Croatian: Sindrom imunološke reaktivacije: u bolesnika inficiranih virusom HIV-a, s teškim imunološkim deficitom u trenutku uvođenja kombinirane antiretrovirusne terapije (CART), može doći do razvoja upalne reakcije na asimptomatske ili oportunističke patogene, što dovodi do klinički ozbiljnog stanja ili pogoršanja simptoma.
English: Bristol-Myers Squibb Pharma EEIG Plaza 254
Croatian: SQUIBB PHARMA EEIG Plaza 254
English: In HIV-infected patients, total clearance of stavudine is 594±164 ml/min, and renal clearance is 237±98 ml/min.
Croatian: Ukupni klirens stavudina u bolesnika inficiranih HIV-om iznosi 594±164 ml/min, a bubrežni klirens 237±98 ml/min.
English: Zidovudine and stavudine are phosphorylated by the cellular enzyme (thymidine kinase), which preferentially phosphorylates zidovudine, thereby decreasing the phosphorylation of stavudine to its active triphosphate form.
Croatian: Stanični enzim (timidin kinaza) fosforilira zidovudin i stavudin i pri tome u prvom redu fosforilira zidovudin te stoga smanjuje fosforilaciju stavudina u njegov aktivni trifosfatni oblik.
English: There was, however, an increased infant mortality in the stavudine + didanosine (10%) treatment group compared to the stavudine (2%), didanosine (3%) or zidovudine (6%) groups, with a higher incidence of stillbirths in the stavudine + didanosine group.
Croatian: Međutim, opažena je povećana smrtnost dojenčadi u skupini liječenoj sa stavudinom + didanozinom (10%), u usporedbi sa skupinama s monoterapijom stavudinom (2%), didanozinom (3%) ili zidovudinom (6%), s većom incidencijom mrtvorođenih u skupini sa stavudinom + didanozinom.
English: These studies include ACTG 240, where 105 paediatric patients ages 3 months to 6 years received Zerit 2 mg/kg/day for a median of 6.4 months; a controlled clinical trial where 185 newborns received Zerit 2 mg/kg/day either alone or in combination with didanosine from birth through 6 weeks of age; and a clinical trial where 8 newborns received Zerit 2 mg/kg/day in combination with didanosine and nelfinavir from birth through 4 weeks of age.
Croatian: Ova ispitivanja uključuju ACTG 240, gdje je 105 pedijatrijskih bolesnika u dobi od 3 mjeseca do 6 godina primalo Zerit u dozi od 2 mg/kg/dan, medijana od 6,4 mjeseci; kontrolirano kliničko ispitivanje gdje je 185 novorođenčadi primalo Zerit u dozi od 2 mg/kg/dan, bilo kao monoterapiju, bilo u kombinaciji s didanozinom od rođenja do 6 tjedana starosti; i kliničko ispitivanje gdje je 8 novorođenčadi primalo Zerit 2 mg/kg/dan u kombinaciji s didanozinom i nelfinavirom od rođenja do starosti od 4 tjedna života.
English: Before reconstitution the Zerit powder appears as off-white to pale-pink, gritty powder.
Croatian: Prije pripreme otopine Zerit prašak je zrnati prašak, gotovo bijele do blijedo ružičaste boje.
English: Children older than 3 months, whose body weight is less than 30 kg, should receive 1 mg/kg twice daily.
Croatian: Djeca starija od 3 mjeseca, čija je tjelesna težina manja od 30 kg, morala bi primiti 1 mg/kg dvaput dnevno.
English: If you are taking didanosine, used to treat HIV infection
Croatian: Ako uzimate didanozin, koji se koristi za liječenje HIV infekcije
English: There have been reports of mitochondrial dysfunction in HIV-negative infants exposed in utero and/or post-natally to nucleoside analogues (see also section 4.8); these have predominantly concerned treatment with regimens containing zidovudine.
Croatian: Postoje podaci o poremećenoj funkciji mitohondrija u HIV-negativne dojenčadi koja su bila izložena in utero i/ili postnatalno analozima nukleozida (vidjeti također dio 4.8); što se najviše odnosi na liječenje režimom koji uključuje zidovudin.
English: In clinical trials, switching from stavudine to other nucleosides (tenofovir or abacavir) resulted in increases in limb fat with modest to no improvements in clinical lipoatrophy.
Croatian: U kliničkim je ispitivanjima zamjena stavudina drugim nukleozidnim lijekovima (tenofovirom ili abakavirom) dovela do povećanja masnog tkiva na udovima, uz izostanak ili umjereno poboljšanje kliničke lipoatrofije.
English: The ingredients of the capsule shell are gelatine, iron oxide colorant (E172), silicon dioxide, sodium laurilsulphate and titanium dioxide colorant (E171).
Croatian: Pomoćne tvari ovojnice kapsule su želatina, boja željezov oksid (E172), silicijev dioksid, natrijev laurilsulfat i boja titanijev dioksid (E171).
English: 20 mg every 24 hours
Croatian: 20 mg svakih 24 sata
English: Adolescents, children and infants: adverse reactions and serious laboratory abnormalities reported to occur in paediatric patients ranging in age from birth through adolescence who received stavudine in clinical studies were generally similar in type and frequency to those seen in adults.
Croatian: Adolescenti, djeca i dojenčad: opisane su nuspojave i ozbiljne abnormalnosti laboratorijskih vrijednosti u pedijatrijskih bolesnika u rasponu godina od rođenja do adolescencije, koji su primali stavudin u kliničkim ispitivanjima, u sličnom opsegu vrste i učestalosti kao i u odraslih bolesnika.
English: Late-onset neurological disorders have been reported rarely (hypertonia, convulsion, abnormal behaviour).
Croatian: Rijetko su prijavljeni neurološi poremećaji s odgođenim nastupom (hipertonija, konvulzije, poremećaj ponašanja).
English: How to store Zerit
Croatian: Kako čuvati Zerit
English: Zerit is indicated in combination with other antiretroviral medicinal products for the treatment of HIV infected adult patients and paediatric patients (over the age of 3 months) only when other antiretrovirals can not be used.
Croatian: Zerit je indiciran u liječenju odraslih bolesnika i pedijatrijskih bolesnika (starijih od 3 mjeseca) zaraženih HIV-om u kombinaciji s drugim antiretrovirusnim lijekovima samo kad se drugi antiretrovirusni lijekovi ne mogu primjeniti.
English: Given these potential risks, a benefit-risk assessment for each patients should be made and an alternative antiretroviral should be carefully considered (see Lactic acidosis, Lipoatrophy, and Peripheral neuropathy below and section 4.8).
Croatian: S obzirom na ove moguće rizike, potrebno je procijeniti omjer rizika i koristi u svakog bolesnika posebno i pažljivo razmotriti alternativnu antiretrovirusnu terapiju (vidjeti Laktična acidoza, Lipoartrofija te niže Periferna neuropatija i dio 4.8).
English: The incidence and severity of lipoatrophy are cumulative over time with stavudine-containing regimens.
Croatian: Incidencija i težina lipoatrofije povećavaju se s vremenom kod terapijskih režima koji sadrže stavudin.
English: common: lipoatrophy**, asymptomatic hyperlactatemia uncommon: lactic acidosis (in some cases involving motor weakness), anorexia rare: hyperglycaemia* very rare: diabetes mellitis*
Croatian: često: lipoatrofija **, asimptomatska hiperlaktatemija manje često: laktična acidoza (koja u nekim slučajevima uključuje motoričku slabost), anoreksija rijetko: hiperglikemija * vrlo rijetko: šećerna bolest*
English: If you develop one of the following, contact your doctor: persistent numbness, tingling or pain in feet and/or hands (this may indicate the beginning of peripheral neuropathy, an adverse effect on the nerves), muscular weakness abdominal pain, nausea or vomiting rapid deep breathing, drowsiness (which may indicate pancreatitis, liver disturbance such as hepatitis, or lactic acidosis).
Croatian: Ako razvijete jedno od slijedećeg, obratite se Vašem liječniku: trajna utrnulost, trnci ili bol u stopalima i/ili rukama (ovo može upućivati na početak periferne neuropatije, nuspojave koja zahvaća živce), mišićna slabost bol u trbuhu, mučnina ili povraćanje, ubrzano duboko disanje, pospanost (koje može upućivati na pankreatitis, poremećaje jetre kao što su hepatitis i laktacidoza).
English: Embryo-foetal toxicities were seen only at high exposure levels in animals.
Croatian: Toksičnost za embrio, odnosno fetus, opisana je u životinja samo za visoku razinu izlaganja.
English: Pancreatitis: patients with a history of pancreatitis had an incidence of approximately 5% on Zerit, as compared to approximately 2% in patients without such a history.
Croatian: Pankreatitis: incidencija pankreatitisa u bolesnika koji su prije imali pankreatitis iznosila je od otprilike 5% za vrijeme primjene lijeka Zerit, u usporedbi s incidencijom od otprilike 2% u bolesnika koji nisu imali pankreatitis u anamnezi.
English: For children whose body weight is 30 kg or more, the usual starting dose is 30 or 40 mg given twice daily (with approximately 12 hours between each dose).
Croatian: U djece s tjelesnom težinom od 30 kg ili više uobičajena početna doza iznosi 30 ili 40 mg i primjenjuje se dvaput dnevno (uz otprilike 12 sati razmaka između dvije doze).
English: To obtain optimal absorption, Zerit should be taken at least one hour before a meal and on an empty stomach.
Croatian: Kako bi se postigla optimalna apsorpcija, Zerit treba uzeti, najmanje jedan sat prije obroka i na prazan želudac.
English: Given these potential risks, a benefit-risk assessment for each patient should be made and an alternative antiretroviral should be carefully considered (see section 4.4 and below).
Croatian: S obzirom na ove potencijalne rizike, potrebno je napraviti procjenu koristi i rizika u svakog bolesnika posebno i pažljivo razmotriti alternativnu antiretrovirusnu terapiju (vidjeti 4.4 i daljnji tekst).
English: Lactic acidosis: lactic acidosis, usually associated with hepatomegaly and hepatic steatosis has been reported with the use of stavudine.
Croatian: Laktična acidoza: kod primjene stavudina opisana je laktična acidoza, obično povezana s hepatomegalijom i steatozom.
English: Off-white to pale-pink, gritty powder.
Croatian: Gotovo bijeli do blijedo ružičasti, zrnati prašak.
English: Zerit dosage
Croatian: Doza lijeka Zerit
English: No clinically relevant pharmacokinetic interaction has, however, been seen with lamivudine.
Croatian: Ipak, uz lamivudin nikakve klinički relevantne farmakokinetičke interakcije nisu opažene.
English: Before treatment with Zerit, you should have told your doctor: if you suffer from kidney disease or liver disease (such as hepatitis) if you have had peripheral neuropathy (persistent numbness, tingling, or pain in the feet and/or hands) if you have suffered from pancreatitis (inflammation of the pancreas).
Croatian: Prije liječenja s lijekom Zerit, obavijestite svog liječnika o sljedećem: ako patite od bolesti bubrega ili jetre (kao što je hepatitis), ako ste imali perifernu neuropatiju (trajna utrnulost, trnce ili bol u stopalima i/ili šakama), ako patite od pankreatitisa (upala gušterače).
English: The solution appears as a colourless to slightly pink, hazy solution.
Croatian: Nastala otopina je bezbojna do lagano ružičasta, magličasta otopina.
English: The other ingredients of the powder contained in the hard capsule are: lactose (120 mg), magnesium stearate, microcrystalline cellulose and sodium starch glycolate.
Croatian: Pomoćne tvari praška sadržane u tvrdoj kapsuli su: laktoza (120 mg), magnezijev stearat, mikrokristalična celuloza i natrijev škroboglikolat.
English: 0.5 mg/kg twice daily (every 12 hours)
Croatian: 0,5 mg/kg dva puta dnevno (svakih 12 sati)
English: Neutropenia (< 750 cells/mm3) was reported in 5%, thrombocytopenia (platelets < 50,000/mm3) in 2%, and low haemoglobin (< 8 g/dl) in < 1% of patients receiving Zerit.
Croatian: U 5% bolesnika opisana je neutropenija (< 750 stanica/mm3), trombocitopenija (trombociti < 50000/mm3) u 2% bolesnika i snižene vrijednosti hemoglobina (< 8 g/dl) kod < 1% bolesnika koji su primali Zerit.
English: Very rare (may affect up to 1 in 10,000 people) thrombocytopenia, neutropenia (blood disorders) diabetes mellitus motor weakness (most often reported in the setting of symptomatic hyperlacetatemia or lactic acidosis syndrome) liver failure
Croatian: Vrlo rijetke (mogu se javiti u manje od 1 na 10 000 osoba) trombocitopenija, neutropenija (krvni poremećaji) šećerna bolest motorička slabost (najčešće zabilježena u okviru simptomatske hiperlaktatemije ili sindroma laktacidoze) zatajenje jetre