FrancophonIA/ELRC3.0 huggingface dataset:
English: Analysis of the composite endpoint in the All ACS population (combined UA/NSTEMI and STEMI cohorts) was contingent on showing statistical superiority of prasugrel versus clopidogrel in the UA/NSTEMI cohort (p < 0.05).
Danish: Analysen af det sammensatte endepunkt i den totale AKS-population (kombinerede UA/NSTEMI- og STEMI-kohorter) var betinget af en påvist statistisk forskel til fordel for prasugrel versus clopidogrel i UA/STEMI-kohorten (p < 0.05).
English: Clots in arteries supplying blood to the heart may also reduce the blood supply, causing unstable angina (a severe chest pain).
Danish: Blodpropper i de blodårer, som fører blod til hjertet, kan også nedsætte blodtilførslen og forårsage ustabil hjertekrampe (angina pectoris, som er alvorlige smerter i brystet).
English: In TRITON, for every 1000 patients treated with Efient, there were 22 fewer patients with myocardial infarction, and 5 more with non-CABG-related TIMI major haemorrhages, compared with patients treated with clopidogrel.
Danish: For hver 1000 patienter, som blev behandlet med Efient, var der i TRITON 22 færre patienter med myokardieinfarkt og 5 flere med ikke-CABG-relateret TIMI større blødninger sammenlignet med patienter i behandling med clopidogrel.
English: • While you are taking Efient:
Danish: Mens du tager Efient:
English: Efient 10 mg: 3 years.
Danish: Efient 10 mg: 3 år.
English: History of TIA or stroke
Danish: Tidligere tilfælde af TIA eller slagtilfælde
English: LIST OF EXCIPIENTS Contains lactose.
Danish: LISTE OVER HJÆLPESTOFFER Indeholder lactose.
English: Prasugrel should be used with caution in patients ≥ 75 years of age due to the potential risk of bleeding in this population
Danish: Prasugrel bør anvendes med forsigtighed til patienter ≥ 75 år på grund af den potentielle blødningsrisiko hos denne befolkningsgruppe (se pkt.
English: Efient is contraindicated in patients with severe hepatic impairment (Child Pugh class C).
Danish: Efient is kontraindiceret til patienter med svært nedsat leverfunktion (Child Pugh klasse C).
English: If you forget to take Efient
Danish: Hvis du har glemt at tage Efient
English: • Bleeding from your rectum, blood in your stools or black stools.
Danish: • Blødning fra endetarmen, blod i din afføring eller sort afføring.
English: NAME OF THE MARKETING AUTHORISATION HOLDER Daiichi-Sankyo (Logo)
Danish: NAVN PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN Daiichi-Sankyo (Logo)
English: Your doctor will also give you acetylsalicylic acid (e.g. aspirin), another antiplatelet agent.
Danish: Din læge vil også give dig acetylsalicylsyre (f.eks Aspirin), som er en anden blodfortyndende medicin.
English: These included definite or probable stent thrombosis at study end (0.9% vs 1.8%; HR 0.498; CI 0.364, 0.683); CV death, nonfatal MI, or urgent target vessel revascularisation through 30 days (5.9% vs 7.4%; HR 0.784; CI 0.688,0.894); all cause death, nonfatal MI, or nonfatal stroke through study end (10.2% vs 12.1%; HR 0.831; CI 0.751, 0.919); CV death, nonfatal MI, nonfatal stroke or rehospitalisation for cardiac ischaemic event through study end (11.7% vs 13.8%; HR 0.838; CI 0.762, 0.921).
Danish: Disse inkluderede endelig eller mulig stenttrombose ved forsøgets slutning (0,9 % mod 1,8 %, HR 0,498, CI 0,364, 0,683), CV død, ikkeletalt MI eller akut revaskularisering (urgent target vessel revascularisation)i løbet af 30 dage (5,9% mod 7,4%, HR 0,784, CI 0,688, 0,894), alle dødsfald, ikke-fatalt MI eller ikke-fatalt slagtilfælde til forsøgets afslutning (10,2% mod 12,1%, HR 0,831, CI 0,751, 0,919), CV død, ikkeletalt MI, ikke-letalt slagtilfælde eller genindlæggelse med iskæmisk hjertesygdom ved studiets afslutning (11,7% mod 13,8%, HR 0,831, CI 0,762, 0,921).
English: Rates of TIMI major bleeding (including life threatening, fatal and ICH) were similar in prasugrel and clopidogrel treated patients.
Danish: Andelen af TIMI større blødning (inklusive livstruende, dødelige og ICH) var sammenlignelige hos prasugrel- og clopidogrelbehandlede patienter.
English: In pre- and post-natal rat studies, maternal treatment had no effect on the behavioural or reproductive development of the offspring at doses up to an exposure 240 times the recommended daily human maintenance dose (based on mg/m2).
Danish: I præ- og postnatale rotteforsøg havde den maternelle behandling ingen virkning på adfærden eller reproduktiv udvikling af afkommet ved doser op til en eksponering 240 gange den anbefalede daglige humane vedligeholdelsesdosis (baseret på mg/m2).
English: When a blood vessel is damaged, for example if it is cut, platelets clump together to help form a blood clot (thrombus).
Danish: Når en blodåre bliver beskadiget, for eksempel hvis der skæres i den, klumper blodpladerne sammen for at hjælpe til med at danne en klump af blod, også kaldet en blodprop.
English: The trial's primary outcome measure was the time to first occurrence of cardiovascular (CV) death, non-fatal myocardial infarction (MI), or non-fatal stroke.
Danish: Forsøgets primære endepunkt var tiden til første tilfælde af kardiovaskulær (CV) død, ikke-letalt myokardieinfarkt (MI) eller ikke-letalt slagtilfælde.
English: Patients with acute coronary syndromes undergoing PCI treated with Efient and ASA showed an increased risk of major and minor bleeding according to the TIMI classification system.
Danish: De patienter med akut koronarsyndrom, som gennemgik PCI og blev behandlet med Efient og ASA, viste en øget risiko for større og mindre blødning i henhold til TIMI-klassifikationssystemet.
English: Patients should be told that it might take longer than usual to stop bleeding when they take prasugrel (in combination with ASA), and that they should report any unusual bleeding (site or duration) to their physician.
Danish: Patienter i behandling med prasugrel (i kombination med ASA) bør informeres om, at det kan tage længere tid end normalt at standse blødninger, og at de bør kontakte deres læge ved enhver usædvanlig blødning (sted og varighed).
English: If clots form within a hardened blood vessel such as an artery they can be very dangerous as they can cut off the blood supply, causing a heart attack (myocardial infarction), stroke or death.
Danish: Hvis blodproppen dannes inden i en forkalket blodåre for eksempel en pulsåre, kan den være meget farlig, da den kan afskære blodforsyningen og forårsage et hjerteanfald (myokardieinfarkt), slagtilfælde eller død.
English: A single intravenous bolus dose of unfractionated heparin (100 U/kg) did not significantly alter the prasugrel-mediated inhibition of platelet aggregation.
Danish: En enkelt intravenøs bolusdosis af ufraktioneret heparin (100 U/kg) forandrede ikke signifikant den prasugrelmedierede hæmning af blodpladeaggregering.
English: In the large phase 3 clinical trial, the mean estimated exposure (AUC) of the active metabolite was 19% higher in very elderly patients (≥ 75 years of age) compared to subjects < 75 years of age.
Danish: I det store kliniske fase 3forsøg var den estimerede gennemsnitlige eksponering (AUC) af den aktive metabolit 19 % højere hos meget gamle patienter (≥ 75 år) sammenlignet med forsøgspersoner < 75 år.
English: Statins:
Danish: Statiner:
English: Pharmacokinetics of prasugrel and its inhibition of platelet aggregation are similar in patients with moderate renal impairment (GFR 30<50 ml/min/1.73m2) and healthy subjects.
Danish: Prasugrels farmakokinetik og dets hæmning af trombocytaggregering er den samme hos patienter med moderat nedsat nyrefunktion (GFR 30<50 ml/min/1.73m2) som hos raske forsøgspersoner.
English: Approximately 68% of the prasugrel dose is excreted in the urine and 27% in the faeces, as inactive metabolites.
Danish: Ca. 68 % af prasugreldosis udskilles som inaktive metabolitter i urinen og 27 % i fæces.
English: The rate of study drug discontinuation due to adverse events was 7.2% for prasugrel and 6.3% for clopidogrel.
Danish: Procenten for seponering af forsøgslægemidler på grund af bivirkninger var 7,2 % for prasugrel og 6,3 % for clopidogrel.
English: You should tell your doctor immediately if you develop a medical condition called Thrombotic Thrombocytopaenic Purpura (or TTP) that includes fever and bruising under the skin that may appear as red pinpoint dots, with or without unexplained extreme tiredness, confusion, yellowing of the skin or eyes (jaundice) (see section 4 ‘Possible side effects').
Danish: Du skal omgående fortælle din læge, hvis du udvikler en tilstand kaldet trombotisk trombocytopenisk purpura (TTP), som viser sig ved feber og blå mærker eller røde nålespidslignende pletter, og som kan være forbundet med uforklarlig, voldsom træthed, forvirring og gulfarvning af hud og øjne (gulsot) (se afsnit 4 ”Bivirkninger”).
English: Patients weighing < 60 kg
Danish: Patienter med vægt < 60 kg
English: Prasugrel 5 mg provided greater antiplatelet effect than clopidogrel 75 mg. Prasugrel should be used with caution in patients ≥ 75 years old and in patients weighing <60 kg (see sections 4.2, 4.4 and 4.8).
Danish: Prasugrel 5 mg gav en større antitrombotisk effekt end clopidogrel 75 mg. Prasugrel skal bruges med forsigtighed hos patienter ≥ 75 år og hos patienter, der vejer <60 kg (se pkt 4.2, 4.4 og 4.8).
English: Medicinal products metabolised by CYP2B6:
Danish: Lægemidler, som metaboliseres af CYP2B6:
English: The safety and efficacy of Efient in children below age 18 has not been established.
Danish: Pædiatrisk populationEfients sikkerhed og virkning hos børn under 18 år er ikke klarlagt.
English: Body weight:
Danish: Legemsvægt:
English: Although not studied in specific interaction studies, Efient has been co-administered in the phase 3 clinical trial with low molecular weight heparin, bivalirudin, and GP IIb/IIIa inhibitors (no information available regarding the type of GP IIb/IIIa inhibitor used) without evidence of clinically significant adverse interactions.
Danish: Selv om der ikke er udført specifikke interaktionsforsøg, har Efient været administreret samtidig i det kliniske fase 3-forsøg med lavmolekylært heparin, bivalirudin og GP IIb/IIIa-inhibitorer (der foreligger ingen information om den anvendte type GP IIb/IIIa-inhibitor) uden tegn på klinisk signifikante uønskede interaktioner.
English: A treatment of up to 12 months is recommended unless the discontinuation of Efient is clinically indicated (see sections 4.4 and 5.1).
Danish: En behandling i op til 12 måneder tilrådes, medmindre seponering af Efient er klinisk indiceret (se pkt.
English: Efient, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with acute coronary syndrome (i.e. unstable angina, non-ST segment elevation myocardial infarction [UA/NSTEMI] or ST segment elevation myocardial infarction [STEMI]) undergoing primary or delayed percutaneous coronary intervention (PCI).
Danish: Efient er i kombination med acetylsalicylsyre (ASA) indiceret til forebyggelse af aterotrombotiske hændelser hos voksne patienter med akut koronarsyndrom (dvs. ustabil angina, myokardieinfarkt uden elevation af ST-segment [UA/NSTEMI] eller myokardieinfarkt [STEMI] med ST-segment elevation, som gennemgår primær eller forsinket perkutan koronarintervention (PCI).
English: Since platelets participate in the initiation and/or evolution of thrombotic complications of atherosclerotic disease, inhibition of platelet function can result in the reduction of the rate of cardiovascular events such as death, myocardial infarction, or stroke.
Danish: Eftersom trombocytter deltager i initieringen og/eller udviklingen af trombotiske komplikationer ved aterosklerotisk sygdom, kan hæmning af trombocytfunktionen medføre reduktion i antallet af kardiovaskulære tilfælde såsom død, myokardieinfarkt eller slagtilfælde.
English: Prasugrel-mediated inhibition of platelet aggregation was also similar in patients with ESRD who required haemodialysis compared to healthy subjects, although Cmax and AUC of the active metabolite decreased 51% and 42%, respectively, in ESRD patients.
Danish: Prasugrelmedieret hæmning af trombocytaggregeringen var ligeledes den samme hos patienter med ESRD, som havde behov for hæmodialyse, sammenlignet med raske forsøgspersoner, på trods af at Cmax og AUC af den aktive metabolit faldt henholdsvis 51% og 42% hos ESRD patienter.
English: Efient 5 mg: 2 years.
Danish: Efient 5 mg: 2 år.
English: All ACS
Danish: Alle AKS
English: The benefits associated with prasugrel were independent of the use of other acute and long-term cardiovascular therapies, including heparin/low molecular weight heparin, bivalirudin, intravenous GPIIb/IIIa inhibitors, lipid-lowering medicinal products, beta-blockers, and angiotensin converting enzyme inhibitors.
Danish: De fordele, som var forbundet med prasugrel, var uafhængige af brugen af andre akutte og langtidsvirkende kardiovaskulære terapier, herunder heparin/lavmolekylært heparin, bivalirudin, intravenøs brug af GPIIb/IIIa-inhibitorer, lipidsænkende lægemidler, betablokkere og angiotensinkonverterende enzymhæmmere.
English: a 10 mg prasugrel; 5 mg prasugrel if ≥75 years of age
Danish: a 10 mg prasugrel; 5 mg prasugrel hvis ≥75 år
English: Of these, bleeding was the most common adverse reaction for both drugs leading to study drug discontinuation (2.5% for prasugrel and 1.4% for clopidogrel).
Danish: Af disse var blødning den mest almindelige bivirkning for begge lægemidler, som førte til seponering af forsøgsmedicinen (2,5 % for prasugrel og 1,4 % for clopidogrel).
English: Therefore, statins that are substrates of CYP3A are not anticipated to have an effect on the pharmacokinetics of prasugrel or its inhibition of platelet aggregation.
Danish: Statiner, som er substrater af CYP3A, forventes derfor ikke at have en virkning på prasugrels farmakokinetik eller dets hæmning af blodpladeaggregering.
English: Stroke is an uncommon side effect of Efient in patients who have never had a stroke or transient ischaemic attack (TIA).
Danish: Slagtilfælde er en ikke almindelig bivirkning ved Efient hos patienter, som ikke tidligere har haft et slagtilfælde eller et forbigående tilfælde af sammentrækning af blodårer (iskæmisk tilfælde/TIA).
English: For patients who received their last dose of thienopyridine within 4 to 7 days prior to CABG, the frequencies decreased to 11.3% (9 of 80 patients) in the prasugrel group and 3.4% (3 of 89 patients) in the clopidogrel group.
Danish: For de patienter, som fik deres sidste dosis af thienopyridin indenfor 4 til 7 dage før CABG, faldt hyppighederne til 11,3 % (9 af 80 patienter) i prasugrelgruppen og 3,4 % (3 af 89 patienter) i clopidogrelgruppen.
English: The incidence of Non-CABG-related TIMI major bleeding, including life-threatening and fatal, as well as TIMI minor bleeding, was statistically significantly higher in subjects treated with prasugrel compared to clopidogrel in the UA/NSTEMI and All ACS populations.
Danish: Incidensen af ikke-CABG-relateret TIMI større blødning, inklusive livstruende og letale blødninger, samt TIMI mindre blødning var statistisk signifikant højere hos de forsøgspersoner, der blev behandlet med prasugrel sammenlignet med clopidogrel hos UA/NSTEMI- og Total AKSpopulationerne.
English: Microcrystalline cellulose, mannitol (E421), croscarmellose sodium, hypromellose (E464) magnesium stearate, lactose monohydrate, titanium dioxide (E171), triacetin (E1518), iron oxide red (10 mg tablets only) (E172), iron oxide yellow (E172) and talc.
Danish: Mikrokrystallinsk cellulose, mannitol (E421), croscarmellosenatrium, hypromellose (E464), magnesiumstearat, lactosemonohydrat, titandioxid (E171), triacetin (E1518), rød jernoxid (kun 10 mg tabletter), (E172), gul jernoxid (E172) og talcum.
English: Patients ≥75 years old or those below 60 kg (N=3022) were randomized to 5 mg prasugrel.
Danish: Patienter ≥75 år eller under 60 kg (N=3.022) blev randomiseret til 5 mg prasugrel.
English: • “non steroidal anti inflammatory drugs” for pain and fever (such as ibuprofen, naproxen, etoricoxib).
Danish: • et ikke-steroidt antiinflammatorisk middel (såsom ibuprofen, naproxen og etoricoxib) mod smerte og feber.
English: The use of prasugrel during breastfeeding is not recommended.
Danish: Brugen af prasugrel under amning frarådes.
English: In a study of healthy subjects, AUC of the active metabolite was unaffected by a high fat, high calorie meal, but Cmax was decreased by 49% and the time to reach Cmax (Tmax) was increased from 0.5 to 1.5 hours.
Danish: I et forsøg med raske forsøgspersoner var AUC af den aktive metabolit upåvirket af et måltid med højt fedt- og kalorieindhold, men Cmax blev sænket med 49 %, og tiden for at nå Cmax(Tmax) blev øget fra ½ time til 1½ time.
English: Efient should be given as a single 60 mg loading dose and then continued at a 5 mg once daily dose.
Danish: Efient bør gives som en enkelt 60 mg loading-dosis og derpå fortsættes med en dosis på 5 mg én gang daglig.
English: In a study of healthy subjects between the ages of 20 and 80 years, age had no significant effect on pharmacokinetics of prasugrel or its inhibition of platelet aggregation.
Danish: I et forsøg med raske forsøgspersoner mellem 20 og 80 år havde alder ingen signifikant virkning på prasugrels farmakokinetik eller dets hæmning af trombocytaggregeringen.
English: Prasugrel's pharmacokinetics are similar in healthy subjects, patients with stable atherosclerosis, and patients undergoing percutaneous coronary intervention.
Danish: Prasugrels farmakokinetik er ens hos raske forsøgspersoner, patienter med stabil aterosklerose og patienter, som gennemgår perkutant koronarindgreb.
English: Patients with UA/NSTEMI within 72 hours of symptoms or STEMI between 12 hours to 14 days of symptoms were randomised after knowledge of coronary anatomy.
Danish: De patienter, som havde UA/NSTEMI med symptomer indenfor 72 timer eller STEMI med symptomer mellem 12 timer til 14 dage, blev randomiseret efter kendskab til koronaranatomi.
English: Name and address of the manufacturer responsible for batch release
Danish: Navn og adresse på de fremstillere, der er ansvarlige for batchfrigivelse
English: Following administration of a 900 mg loading dose of clopidogrel (with ASA), 56 subjects with ACS were treated for 14 days with either prasugrel 10 mg once daily or clopidogrel 150 mg once daily, and then switched to either clopidogrel 150 mg or prasugrel 10 mg for another 14 days.
Danish: Efter administration af en 900 mg loading-dosis af clopidogrel (med ASA), blev 56 forsøgspersoner med AKS behandlet i 14 dage med enten 10 mg prasugrel én gang daglig eller 150 mg clopidogrel én gang daglig og derpå skiftet til enten 150 mg clopidogrel eller 10 mg prasugrel i yderligere 14 dage.
English: Film-Coat:
Danish: Filmovertræk:
English: What Efient contains - The active substance is prasugrel.
Danish: Efient indeholder: - Aktivt stof: prasugrel.
English: Do not take Efient - If you are allergic (hypersensitive) to prasugrel or any of the other ingredients of Efient.
Danish: Tag ikke Efient - Hvis du er allergisk over for prasugrel eller et af de øvrige indholdsstoffer (angivet i afsnit 6).
English: What you need to know before you take Efient
Danish: Det skal du vide, før du begynder at tage Efient
English: Hypersensitivity reactions including angioedema have been reported in patients receiving prasugrel, including in patients with a history of hypersensitivity reaction to clopidogrel.
Danish: Der er indberettet overfølsomhedsreaktioner, herunder angioødem, hos patienter i behandling med prasugrel, inklusive patienter med overfølsomhedsreaktioner over for clopidogrel i anamnesen.
English: You should tell your doctor before taking Efient if any of the situations mentioned below apply to you:
Danish: Kontakt lægen eller apoteketspersonalet, før du tager Efient, hvis nogen af nedennævnte situationer gælder for dig:
English: Requiring inotropes Requiring surgical intervention Requiring transfusion (≥ 4
Danish: Behov for behandling med inotrope midler Behov for kirurgisk indgreb Behov for transfusion (≥4 enheder) TIMI mindre blødningf
English: Microcrystalline cellulose Mannitol (E421) Croscarmellose sodium Hypromellose (E464) Magnesium stearate
Danish: Mikrokrystallinsk cellulose Mannitol (E421) Croscarmellosenatrium Hypromellose (E464) Magnesiumstearat
English: Monitoring for signs of hypersensitivity in patients with a known allergy to thienopyridines is advised (see section 4.8).
Danish: Det anbefales at monitorere for tegn på overfølsomhed hos patienter med allergi over for thienopyridiner (se pkt.
English: In healthy subjects, prasugrel decreased exposure to hydroxybupropion, a CYP2B6-mediated metabolite of bupropion, by 23%.
Danish: Prasugrel formindskede eksponeringen for hydroxybupropion, en CYP2B6-medieret metabolit af bupropion, med 23 % hos raske forsøgspersoner.
English: • clopidogrel (an anti-platelet agent),
Danish: • clopidogrel (et blodfortyndende middel),
English: Therefore, known CYP3A inducers such as rifampicin, carbamazepine, and other inducers of cytochromes P450 are not anticipated to have significant effect on the pharmacokinetics of the active metabolite.
Danish: Kendte CYP3A induktorer såsom rifampicin, carbamazepin og andre induktoreraf P450 cytokromer forventes derfor ikke at have signifikant virkning på den aktive metabolits farmakokinetik.
English: Prasugrel had no effect on fertility of male and female rats at oral doses up to an exposure 240 times the recommended daily human maintenance dose (based on mg/m2).
Danish: Prasugrel har ingen virkning på fertilitet hos han- og hunrotter ved orale doser op til en eksponering på 240 gange den anbefalede daglige vedligeholdelsesdosis hos mennesker (baseret på mg/m2).
English: In a 30 month study (TRILOGY-ACS) in 9326 patients with UA/NSTEMI ACS medically managed without revascularisation (non-licensed indication), prasugrel did not significantly reduce the frequency of the composite endpoint of CV death, MI or stroke compared to clopidogrel.
Danish: I et 30-måneders studie (TRILOGY-ACS) med 9.326 patienter med UA/NSTEMI AKS, behandlet medicinsk uden revaskularisering (ikke godkendt indikation), reducerede prasugrel ikke hyppigheden af det sammensatte endepunkt kardiovaskulær død, myokardieinfarkt eller apopleksi signifikant sammenlignet med clopidogrel.
English: a 10 mg prasugrel; 5 mg prasugrel if <60 kg
Danish: a 10 mg prasugrel; 5 mg prasugrel hvis <60 kg
English: Severe hepatic impairment (Child Pugh class C).
Danish: Svært nedsat leverfunktion (Child Pugh-klasse C).
English: Atorvastatin (80 mg daily) did not alter the pharmacokinetics of prasugrel and its inhibition of platelet aggregation.
Danish: Atorvastatin (80 mg daglig) ændrede ikke prasugrels farmakokinetik og dets hæmning af blodpladeaggregering.
English: Study TADO tested the use of prasugrel (n=171) vs placebo (n=170) in patients, ages 2 to less than 18 years of age, with sickle cell anaemia for reduction of vaso occlusive crisis in a phase III study.
Danish: I fase III-studiet TADO blev brugen af prasugrel (n=171) vs placebo (n=170) undersøgt til reduktion af vaso-okklusiv krise hos patienter med seglcelleanæmi i alderen 2 år og op til 18 år.
English: The active metabolite's exposure (AUC) has moderate to low between-subject (27%) and within-subject (19%) variability.
Danish: Den aktive metabolits eksponering (AUC) har moderat til lav varians imellem forsøgspersoner (27%) og hos forsøgspersoner (19%).
English: • Before you are taking Efient:
Danish: Før du tager Efient:
English: Blood and Lymphatic System disorders
Danish: Blod og lymfesystem Anæmi
English: In healthy subjects, patients with stable atherosclerosis, and patients with ACS receiving Efient, there was no relevant effect of genetic variation in CYP3A5, CYP2B6, CYP2C9, or CYP2C19 on the pharmacokinetics of prasugrel or its inhibition of platelet aggregation.
Danish: Hos raske forsøgspersoner, patienter med stabil aterosklerose og patienter med AKS, som fik Efient, gav genetisk variation i CYP3A5, CYP2B6, CYP2C9 eller CYP2C19 ingen relevant virkning på prasugrels farmakokinetik eller dets hæmning af trombocytaggregeringen.