FrancophonIA/ELRC3.0 huggingface dataset:
English: The clinically relevant effects noted were a reduction in red blood cell count and neutropenia.
Danish: Af klinisk relevans sås en reduktion i antallet af erytrocytter og neutropeni.
English: Uncommon nightmare, depression 2, anxiety 3, irritability, confusional state, suicidal ideation
Danish: Ikke almindelig mareridt, depression 2, angst 3, irritabilitet,
English: Refer to Resistance section for NNRTI substitutions that were part of exclusion criteria.
Danish: NNRTIsubstitutioner, der var del af eksklusionskriterierne, er angivet i afsnittet om resistens.
English: Co-administration of doravirine with other moderate CYP3A inducers has not been evaluated, but decreased doravirine concentrations are expected.
Danish: Samtidig administration af doravirin og andre moderate CYP3A-induktorer er ikke blevet vurderet, men der forventes en nedsat koncentration af doravirin.
English: Clinical isolates containing the Y188L substitution or V106 substitutions in combination with A98G, H221Y, P225H, F227C or Y318F showed a greater than 100-fold reduced susceptibility to doravirine.
Danish: Kliniske isolater med Y188L-substitution eller V106-substitutioner i kombination med A98G, H221Y, P225H, F227C eller Y318F viste en større end 100 gange reduktion i følsomhed over for doravirin.
English: If you are not sure, talk to your doctor, pharmacist, or nurse before taking Delstrigo.
Danish: Hvis du er i tvivl, så kontakt lægen, apotekspersonalet eller sundhedspersonalet, før du tager Delstrigo.
English: Hypophosphataemia and osteomalacia secondary to proximal renal tubulopathy should be considered in patients at risk of renal dysfunction who present with persistent or worsening bone or muscle symptoms while receiving products containing tenofovir disoproxil (see section 4.4).
Danish: Hypofosfatæmi og osteomalaci sekundært til proksimal renal tubulopati skal overvejes hos patienter med risiko for dysfunktion af nyrerne, som oplever persisterende eller tiltagende knogle- eller muskelsymptomer, mens de får lægemidler, der indeholder tenofovirdisoproxil (se pkt.
English: • increased levels of creatine phosphokinase
Danish: • forhøjet af indhold af kreatinfosfokinase.
English: + T cell count < 200 cells per mm
Danish: + T-celletal på < 200 celler pr. mm
English: Animal studies with tenofovir disoproxil do not indicate direct or indirect harmful effects of tenofovir disoproxil with respect to reproductive toxicity (see section 5.3).
Danish: Dyreforsøg med tenofovirdisoproxil indikerer hverken direkte eller indirekte skadelige virkninger af tenofovirdisoproxil, hvad angår reproduktionstoksicitet (se pkt.
English: Bottle label
Danish: Etiket til tabletflaske
English: Biotransformation Based on in vitro data, doravirine is primarily metabolised by CYP3A.
Danish: På baggrund af in vitro-data metaboliseres doravirin primært via CYP3A.
English: Expected:  doravirine
Danish: Forventet:  doravirin
English: Rare blood creatine phosphokinase increased
Danish: Sjælden forhøjet kreatinfosfokinase i blodet
English: Very rare pure red cell aplasia*
Danish: Meget sjælden ren erytrocyt aplasi*
English: The pharmacokinetics of doravirine were studied in healthy subjects and HIV-1-infected subjects.
Danish: Doravirins farmakokinetik blev undersøgt hos raske forsøgspersoner og hiv-1-inficerede forsøgspersoner.
English: Successful genotype, n Genotypic resistance to DOR or control (DRV or EFV) 2 (DOR)
Danish: DOR eller kontrol (DRV eller EFV)
English: Expected:  norgestimate/ethinyl oestradiol
Danish: Forventet:  norgestimat/ethinylestradiol
English: No dose adjustment is required in patients with mild or moderate hepatic impairment.
Danish: Dosisjustering er ikke nødvendig hos patienter med let nedsat eller moderat nedsat leverfunktion.
English: • pain in the chest, feeling cold, pain, thirst
Danish: • brystsmerter, kuldefølelse, smerter, tørst.
English: In addition, a K70E substitution in HIV-1 RT has been selected by tenofovir and results in low-level reduced susceptibility to abacavir, emtricitabine, lamivudine, and tenofovir.
Danish: Derudover er en K70Esubstitution i hiv-1-RT blevet selekteret for ved anvendelse af tenofovir, som resulterer i, at følsomheden over for abacavir, emtricitabin, lamivudin og tenofovir nedsættes i mindre grad.
English: Patients with moderate or severe renal impairment require a dose interval adjustment of lamivudine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.4 and 5.2).
Danish: Patienter med moderat eller svært nedsat nyrefunktion kræver en trinvis dosisjustering af lamivudin og tenofovirdisoproxil, der ikke er mulig med kombinationstabletten (se pkt.
English: If co-administration with other moderate CYP3A inducers (e.g., dabrafenib, lesinurad, bosentan, thioridazine, nafcillin, modafinil, telotristat ethyl) cannot be avoided, one 100 mg tablet of doravirine should be taken daily, approximately 12 hours after the dose of Delstrigo (see section 4.5).
Danish: Hvis administration sammen med andre moderate CYP3A-induktorer (f.eks. dabrafenib, lesinurad, bosentan, thioridazin, nafcillin, modafinil, telotristatethyl) ikke kan undgås, skal en 100 mg tablet doravirin tages dagligt ca. 12 timer efter Delstrigo (se pkt.
English: 12 hours, skip the dose you missed and take the next one at the usual time.
Danish: Hvis din næste dosis imidlertid skal tages inden for 12 timer, så spring den glemte dosis over, og tag den næste dosis på det sædvanlige tidspunkt.
English: No dose adjustment is required in patients with mild, moderate or severe renal impairment.
Danish: Dosisjustering er ikke nødvendig hos patienter med let nedsat, moderat nedsat eller svært nedsat nyrefunktion.
English: Doravirine demonstrated antiviral activity against a broad panel of primary HIV-1 isolates (A, A1, AE, AG, B, BF, C, D, G, H) with EC50 values ranging from 1.2 nM to 10.0 nM.
Danish: Doravirin udviste antiviral aktivitet mod et bredt panel af primære hiv-1-isolater (A, A1, AE, AG, B, BF, C, D, G, H) med EC50-værdier fra 1,2 nM til 10,0 nM. Doravirins antivirale aktivitet var ikke antagonistisk ved kombination med lamivudin og tenofovirdisoproxil.
English: However, tenofovir disoproxil reduced the viability index and weight of pups in a peri-postnatal toxicity study at maternally toxic doses.
Danish: I et studie af peri- og postnatal toksicitet reducerede tenofovirdisoproxil imidlertid levedygtighedsindekset og vægten hos afkom ved maternelt toksiske doser.
English: A breakpoint for a reduction in susceptibility, yielded by various NNRTI substitutions, that is associated with a reduction in clinical efficacy has not been established (see section 5.1).
Danish: Der er ikke klarlagt et breakpoint for reduktion i følsomhed forårsaget af forskellige NNRTI-substitutioner, der er forbundet med reduktion i klinisk virkning (se pkt.
English: Co-administration of doravirine/lamivudine/tenofovir disproxil and medicinal products that are inhibitors of CYP3A may result in increased plasma concentrations of doravirine.
Danish: Samtidig administration af doravirin/lamivudin/tenofovirdisoproxil og lægemidler, der er CYP3Ahæmmere, kan resultere i en øget plasmakoncentration af doravirin.
English: Doravirine/lamivudine/tenofovir disoproxil should not be co-administered with medicinal products that are strong CYP3A enzyme inducers as significant decreases in doravirine plasma concentrations are expected to occur, which may decrease the effectiveness of doravirine/lamivudine/tenofovir disoproxil (see sections 4.3 and 5.2).
Danish: Doravirin/lamivudin/tenofovirdisoproxil må ikke administreres sammen med lægemidler, der er potente CYP3A-enzyminduktorer, da der forventes at forekomme et signifikant fald i plasmakoncentrationen af doravirin, hvilket kan nedsætte doravirin/lamivudin/tenofovirdisoproxils virkning (se pkt.
English: Severe acute exacerbation of hepatitis B in patients co-infected with HIV-1 and HBV All patients with HIV-1 should be tested for the presence of hepatitis B virus (HBV) before initiating antiretroviral therapy.
Danish: Alle patienter med hiv-1 skal testes for tilstedeværelse af hepatitis B-virus (hbv), før antiretroviral behandling initieres.
English: Compared with subjects with normal renal function, the mean (% CV) tenofovir exposure increased from 2,185 (12 %) ng·h/mL in subjects with CrCl > 80 mL/min to respectively 3,064 (30 %) ng·h/mL, 6,009 (42 %) ng·h/mL and 15,985 (45 %) ng·h/mL in subjects with mild, moderate, and severe renal impairment.
Danish: 2.185 (12%) ng·t/ml hos forsøgspersoner med CrCl > 80 ml/min til henholdsvis 3.064 (30%) ng·t/ml, 6.009 (42%) ng·t/ml og 15.985 (45%) ng·t/ml hos forsøgspersoner med let nedsat, moderat nedsat og svært nedsat nyrefunktion.
English: Doravirine/lamivudine/tenofovir disoproxil must not be co-administered with other medicinal products containing lamivudine, or with medicinal products containing tenofovir disoproxil, or tenofovir alafenamide, or with adefovir dipivoxil (see section 4.5).
Danish: Doravirin/lamivudin/tenofovirdisoproxil må ikke administreres sammen med andre lægemidler, der indeholder lamivudin, eller sammen med lægemidler, der indeholder tenofovirdisoproxil eller tenofoviralafenamid, eller sammen med adefovirdipivoxil (se pkt.
English: In in vitro studies, doravirine was able to suppress the following NNRTI-associated substitutions; K103N, Y181C, and G190A under clinically relevant concentrations.
Danish: I in vitro-studier var doravirin ved klinisk relevante koncentrationer i stand til at undertrykke følgende NNRTI-associerede substitutioner: K103N, Y181C og G190A.
English: In an in vivo mouse micronucleus assay, tenofovir disoproxil was negative when administered to male mice.
Danish: I en in vivo-musemikronukleusanalyse var tenofovirdisoproxil negativt, når det blev administreret til hanmus.
English: Geometric Mean Ratio (90 % CI)*
Danish: Indvirkning på lægemiddelniveauer Geometrisk gennemsnitsratio (90% CI)*
English: Lamivudine
Danish: Lamivudin
English: Table 2: Tabulated summary of adverse reactions associated with doravirine/lamivudine/tenofovir disoproxil
Danish: Tabel 2: Tabel over bivirkninger associeret med doravirin/lamivudin/tenofovirdisoproxil
English: Doravirine/lamivudine/tenofovir disoproxil should not be administered with doravirine unless needed for dose adjustment (e.g., with rifabutin) (see sections 4.2 and 4.5).
Danish: Doravirin/lamivudin/tenofovirdisoproxil må ikke administreres sammen med doravirin, medmindre det er nødvendigt for dosisjustering (f.eks. med rifabutin) (se pkt.
English: Effects of other medicinal products on doravirine, lamivudine, and tenofovir disoproxil Doravirine
Danish: Andre lægemidlers indvirkning på doravirin, lamivudin og tenofovirdisoproxil
English: Autoimmune disorders (such as Graves' disease, autoimmune hepatitis, polymyositis, and GuillainBarré syndrome) have also been reported to occur in the setting of immune reactivation; however, the time to onset is more variable and can occur many months after initiation of treatment.
Danish: Autoimmune sygdomme (f.eks. Graves sygdom, autoimmun hepatitis, polymyositis og Guillain-Barrés syndrom) er også rapporteret at forekomme ved immunreaktivering.
English: Acid-Reducing Agents antacid (aluminium and magnesium hydroxide oral suspension) (20 mL SD, doravirine 100 mg SD)
Danish: Syrereducerende midler antacidum (aluminium- og magnesiumhydroxid, oral suspension) (20 ml enkeltdosis, doravirin 100 mg enkeltdosis)
English: • feeling tired, fever
Danish: • træthedsfølelse, feber.
English: Delstrigo works by preventing HIV from making more viruses in your body.
Danish: Delstrigo virker ved at hæmme hiv-virusets evne til at formere sig (lave kopier af sig selv) i kroppen.
English: Delstrigo 100 mg / 300 mg / 245 mg film-coated tablets doravirine/lamivudine/tenofovir disoproxil
Danish: Delstrigo 100 mg / 300 mg / 245 mg filmovertrukne tabletter doravirin/lamivudin/tenofovirdisoproxil
English: Effects of doravirine, lamivudine, and tenofovir disoproxil on other medicinal products Doravirine
Danish: Doravirin, lamivudin og tenofovirdisoproxils indvirkning på andre lægemidler
English: Delstrigo should be discontinued if estimated CrCl declines below 50 mL per minute (see section 4.4).
Danish: Delstrigo skal seponeres, hvis den estimerede CrCl falder til under 50 ml pr. minut (se pkt.
English: Uncommon myalgia, arthralgia, rhabdomyolysis* muscular weakness*
Danish: Ikke almindelig myalgi, artralgi, rabdomyolyse* muskelsvaghed*
English: Observed emergent amino acid substitutions in RT included: V106A, V106M, V106I, V108I, F227L, F227C, F227V, H221Y, M230I, L234I, P236L, and Y318F.
Danish: Observerede aminosyresubstitutioner i RT omfattede: V106A, V106M, V106I, V108I, F227L, F227C, F227V, H221Y, M230I, L234I, P236L og Y318F.
English: Expected:  doravirine ↓ tacrolimus, sirolimus (Induction of CYP3A)
Danish: Forventet:  doravirin ↓ tacrolimus, sirolimus (CYP3A-induktion)
English: Croscarmellose sodium (E468) Hypromellose acetate succinate Magnesium stearate (E470b) Microcrystalline cellulose (E460) Silica, colloidal anhydrous (E551) Sodium stearyl fumarate
Danish: Croscarmellosenatrium (E468) Hypromelloseacetatsuccinat Magnesiumstearat (E470b) Mikrokrystallinsk cellulose (E460) Silica, kolloid vandfri (E551) Natriumstearylfumarat
English: Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α, β, and mitochondrial DNA polymerase γ.
Danish: Tenofovirdifosfat er en svag hæmmer af DNA-polymerase α, ß og mitokondrie-DNA-polymerase γ hos pattedyr.
English: Doravirine pharmacokinetics are similar in healthy subjects and HIV-1-infected subjects.
Danish: Doravirins farmakokinetik er sammenlignelig hos raske forsøgspersoner og hiv-1inficerede forsøgspersoner.
English: lamivudine + tenofovir disoproxil (300 mg lamivudine SD + 245 mg tenofovir disoproxil SD, doravirine 100 mg SD)
Danish: lamivudin + tenofovirdisoproxil (300 mg lamivudin enkeltdosis + 245 mg tenofovirdisoproxil enkeltdosis, doravirin 100 mg enkeltdosis)
English: Antimycobacterials
Danish: Antimykobakterielle midler
English: Sedatives/Hypnotics midazolam (2 mg SD, doravirine 120 mg QD)
Danish: Sedativa/hypnotika midazolam (2 mg enkeltdosis, doravirin 120 mg en gang dagligt)
English: St. John's wort (Hypericum perforatum)
Danish: Naturlægemidler perikon (Hypericum perforatum)
English: No clinically relevant differences in tenofovir pharmacokinetics were observed between subjects with hepatic impairment and healthy subjects.
Danish: Der blev ikke observeret klinisk relevante forskelle i tenofovirs farmakokinetik mellem forsøgspersoner med nedsat leverfunktion og raske forsøgspersoner.
English: Doravirine-resistant strains were selected in cell culture starting from wild-type HIV-1 of different origins and subtypes, as well as NNRTI-resistant HIV-1.
Danish: I cellekultur, der havde sit udspring i vildtype-hiv-1 af forskellige oprindelser og undertyper såvel som NNRTI-resistent hiv-1, blev der selekteret for doravirin-resistente stammer.
English: DOR + 2 NRTIs (383) DRV+r + 2 NRTIs
Danish: DRV+ r + 2 NRTIer (383)
English: Interaction not studied with doravirine or doravirine/lamivudine/tenofovir disoproxil.
Danish: Interaktion med doravirin eller doravirin/lamivudin/tenofovirdisoproxil er ikke undersøgt.
English: Co-administration with medicinal products that are strong cytochrome P450 CYP3A enzyme inducers is contraindicated as significant decreases in doravirine plasma concentrations are expected to occur, which may decrease the effectiveness of Delstrigo (see sections 4.4 and 4.5).
Danish: Samtidig administration med lægemidler, der er potente CYP3A-enzyminduktorer, er kontraindiceret, da der forventes at forekomme et signifikant fald i plasmakoncentrationen af doravirin, hvilket kan nedsætte Delstrigos virkning (se pkt.
English: Film-coating Carnauba wax (E903) Hypromellose (E464) Iron oxide yellow (E172) Lactose monohydrate Titanium dioxide (E171) Triacetin (E1518)
Danish: Carnaubavoks (E903) Hypromellose (E464) Gul jernoxid (E172) Lactosemonohydrat Titandioxid (E171) Triacetin (E1518)
English:  doravirine AUC 0.12 (0.10, 0.15) Cmax 0.43 (0.35, 0.52) C24 0.03 (0.02, 0.04) (Induction of CYP3A)
Danish:  doravirin AUC 0,12 (0,10; 0,15) Cmax 0,43 (0,35; 0,52) C24 0,03 (0,02; 0,04) (CYP3A-induktion)
English: Proportion (%) of Subjects With HIV-1 RNA < 40 copies/mL by Baseline Regimen Received
Danish: Del (%) af forsøgspersoner med hiv-1 RNA < 40 kopier/ml med baseline-regime modtog
English: • The other ingredients are croscarmellose sodium E468; hypromellose acetate succinate; magnesium stearate E470b; microcrystalline cellulose E460; silica, colloidal anhydrous E551; sodium stearyl fumarate.
Danish: • Øvrige indholdsstoffer: croscarmellosenatrium (E468), hypromelloseacetatsuccinat, magnesiumstearat (E470b), mikrokrystallinsk cellulose (E460), silica, kolloid vandfri (E551) og natriumstearylfumarat.
English: • feeling sick (nausea), diarrhoea, stomach pain, vomiting, wind (flatulence)
Danish: • kvalme, diarré, mavesmerter, opkastning, luft i maven (flatulens)
English: Hepatitis C Antiviral Agents elbasvir + grazoprevir (50 mg elbasvir QD + 200 mg grazoprevir QD, doravirine 100 mg QD)
Danish: Hepatitis C-antivirale midler elbasvir + grazoprevir (50 mg elbasvir en gang dagligt + 200 mg grazoprevir en gang dagligt, doravirin 100 mg en gang dagligt)
English: Package leaflet: Information for the user Delstrigo 100 mg/300 mg/245 mg film-coated tablets doravirine/ lamivudine/ tenofovir disoproxil
Danish: Indlægsseddel: Information til brugeren Delstrigo 100 mg/300 mg/245 mg filmovertrukne tabletter doravirin/lamivudin/tenofovirdisoproxil
English: Metabolism of lamivudine is a minor route of elimination.
Danish: Lamivudin elimineres i mindre grad via metabolisering.
English: Proportion (%) of Subjects With HIV-1 RNA < 40 copies/mL by Baseline CD4
Danish: Del (%) af forsøgspersoner med hiv-1 RNA < 40 kopier/ml ved baseline CD4
English: If co-administration with other moderate CYP3A inducers (e.g., debrafenib, lesinurad, bosentan, thioridazine, nafcillin, modafinil, telotristat ethyl) cannot be avoided, a 100 mg dose of doravirine should be administered daily, approximately 12 hours after the administration of doravirine/lamivudine/tenofovir disoproxil dose (see section 4.2).
Danish: Hvis administration sammen med andre moderate CYP3A-induktorer (f.eks. dabrafenib, lesinurad, bosentan, thioridazin, nafcillin, modafinil, telotristatethyl) ikke kan undgås, skal en 100 mg dosis doravirin administreres dagligt ca. 12 timer efter administration af doravirin/lamivudin/tenofovirdisoproxil (se pkt.
English: Emergent doravirine associated resistance substitutions in RT included one or more of the following: A98G, V106I, V106A, V106M/T, Y188L, H221Y, P225H, F227C, F227C/R, and Y318Y/F.
Danish: Opståede substitutioner i RT associeret med resistens over for doravirin inkluderede en eller flere af følgende: A98G, V106I, V106A, V106M/T, Y188L, H221Y, P225H, F227C, F227C/R og Y318Y/F.
English: HIV-1 RNA copies/mL
Danish: Hiv-1-RNA kopier/ml
English: Delstrigo should not be initiated in patients with estimated CrCl < 50 mL/min (see sections 4.4 and 5.2).
Danish: Delstrigo må ikke initieres hos patienter med en estimeret CrCl på < 50 ml/min (se pkt.
English: Patients receiving doravirine/lamivudine/tenofovir disoproxil concomitantly with sofosbuvir/velpatasvir should be monitored for adverse reactions associated with tenofovir disoproxil.
Danish: Patienter, der får doravirin/lamivudin/tenofovirdisoproxil sammen med sofosbuvir/velpatasvir, skal monitoreres for bivirkninger associeret med tenofovirdisoproxil.
English: Patients receiving doravirine/lamivudine/tenofovir disoproxil concomitantly with ledipasvir/sofosbuvir should be monitored for adverse reactions associated with tenofovir disoproxil.
Danish: Patienter, der får doravirin/lamivudin/tenofovirdisoproxil sammen med ledipasvir/sofosbuvir, skal monitoreres for bivirkninger associeret med tenofovirdisoproxil.
English: Impairment of fertility
Danish: Indvirkning på fertilitet
English: The tablets are film-coated with a coating material containing the following ingredients: carnauba wax E903, hypromellose E464; iron oxide yellow E172; lactose monohydrate; titanium dioxide E171; and triacetin E1518.
Danish: Tabletterne er filmovertrukket med et overtræksmaterialemed følgende indholdsstoffer: carnaubavoks (E903), hypromellose (E464), gul jernoxid (E172), lactosemonohydrat, titandioxid (E171) og triacetin (E1518).
English: Caution should be given to prescribing doravirine with medicinal products that may reduce the exposure of doravirine (see sections 4.3 and 4.5).
Danish: Doravirin skal ordineres med forsigtighed sammen med lægemidler, der kan nedsætte eksponeringen for doravirin (se pkt.
English: If doravirine/ lamivudine/ tenofovir disoproxil is coadministered with rifabutin, a 100 mg dose of doravirine should be taken daily, approximately 12 h after dose of doravirine/lamivudine/tenofovir disoproxil.
Danish: Hvis doravirin/lamivudin/tenofovirdisoproxil administreres samtidigt med rifabutin, skal en 100 mg dosis doravirin tages dagligt ca. 12 timer efter dosis af doravirin/lamivudin/tenofovirdisoproxil.
English: Recommendation Concerning Co-administration with doravirine/lamivudine/tenofo vir disoproxil ledipasvir + sofosbuvir (90 mg ledipasvir SD + 400 mg sofosbuvir SD, doravirine 100 mg SD)
Danish: Anbefalinger vedrørende administration sammen med doravirin/lamivudin/tenofovirdisoproxil ledipasvir + sofosbuvir (90 mg ledipasvir enkeltdosis +
English: HIV-1 RNA ≥ 40 copies/mL
Danish: Hiv-1 RNA ≥ 40 kopier/ml
English: • The active substances are 100 mg of doravirine, 300 mg of lamivudine and 245 mg of tenofovir disoproxil (as fumarate)
Danish: • Aktive stoffer: 100 mg doravirin, 300 mg lamivudin og 245 mg tenofovirdisoproxil (som fumarat).
English: flatulence
Danish: flatulens
English: Gastrointestinal disorders Common nausea, diarrhoea, abdominal pain 4, vomiting,
Danish: Mave-tarm-kanalen Almindelig kvalme, diarré, abdominalsmerter
English: Lamivudine Lamivudine did not affect male or female fertility in rats.
Danish: Lamivudin Lamivudin havde ingen indvirkning på fertiliteten hos han- eller hunrotter.
English: Co-administration of doravirine/lamivudine/tenofovir disoproxil with other moderate CYP3A inducers has not been evaluated, but decreased doravirine concentrations are expected.
Danish: Samtidig administration af doravirin/lamivudin/tenofovirdisoproxil og andre moderate CYP3Ainduktorer er ikke vurderet, men der forventes en nedsat koncentration af doravirin.
English: Kinase Inhibitors dabrafenib
Danish: Kinasehæmmere dabrafenib
English: • decreased levels phosphate
Danish: • nedsat indhold af fosfat
English: HIV-1 RNA < 40 copies/mL
Danish: Hiv-1 RNA < 40 kopier/ml
English: norgestimate/ethinyl oestradiol
Danish: norgestimat/ethinylestradiol
English: Do not run out of Delstrigo.
Danish: Tag ikke Delstrigo
English: Doravirine has not been studied in subjects with severe hepatic impairment (Child-Pugh score C) (see section 4.2).
Danish: Doravirin er ikke undersøgt hos forsøgspersoner med svært nedsat leverfunktion (Child-Pugh-score C) (se pkt.
English:  doravirine AUC 3.06 (2.85, 3.29) Cmax 1.25 (1.05, 1.49) C24 2.75 (2.54, 2.98) (Inhibition of CYP3A)
Danish:  doravirin AUC 3,06 (2,85; 3,29) Cmax 1,25 (1,05; 1,49) C24 2,75 (2,54; 2,98) (CYP3A-hæmning)
English: Discontinuation due to adverse events
Danish: Udtræden af studiet på grund af bivirkninger
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Danish: Delstrigo indeholder lactosemonohydrat og må ikke anvendes til patienter med arvelig galactoseintolerans, total lactasemangel eller glucose/galactosemalabsorption.
English: Hepatobiliary disorders Rare hepatic steatosis*, hepatitis*
Danish: Lever og galdeveje Sjælden fedtlever*, hepatitis*
English: Antidiarrhoeals telotristat ethyl
Danish: Midler mod diarré telotristatethyl
English: • Lamivudine - a nucleoside analogue reverse transcriptase inhibitor (NRTI)
Danish: • lamivudin - en nukleosidanalog revers transkriptasehæmmer (NRTI)
English: • bosentan (a medicine to treat lung disease)
Danish: • bosentan (et lægemiddel til behandling af lungesygdom)