FrancophonIA/ELRC3.0 huggingface dataset:
English: Severe (e.g., Grade 3) or intolerable adverse reactions require interruption of lenvatinib until improvement of the reaction to Grade 0-1 or baseline.
Danish: Svære (f.eks. grad 3) eller intolerable bivirkninger kræver afbrydelse af lenvatinib, indtil reaktionerne forbedres til grad 0-1 eller baseline.
English: Plasma concentrations decline bi-exponentially following Cmax.
Danish: Plasmakoncentrationerne falder bieksponentielt efter Cmaks.
English: Antihypertensive agents should be started as soon as elevated BP is confirmed.
Danish: Antihypertensive midler skal startes så snart et forhøjet blodtryk er blevet bekræftet.
English: Lenvatinib dose interruption due to hypocalcaemia occurred in one subject (0.2%) and there were no dose reductions or discontinuations.
Danish: Dosisafbrydelse af lenvatinib på grund af hypocalcæmi forekom hos en forsøgsperson (0,2%), og der var ingen dosisreduktioner eller seponeringer.
English: Discontinue Do not resume *Grade 4 laboratory abnormalities judged to be non-life-threatening, may be managed as severe reactions (e.g., Grade 3)
Danish: Må ikke genstartes *Grad 4 laboratorieanomalier, der bedømmes til ikke at være livstruende, kan behandles som svære reaktioner (f.eks. grad 3)
English: In patients with solid tumours administered single and multiple doses of lenvatinib once daily, exposure to lenvatinib (Cmax and AUC) increased in direct proportion to the administered dose over the range of 3.2 to 32 mg once-daily.
Danish: Hos patienter med faste tumorer, der fik administreret enkelte og flere doser af lenvatinib én gang dagligt, var eksponeringen for lenvatinib (Cmaks og AUC) forhøjet direkte proportionalt med den administrerede dosis i intervallet fra 3,2 til 32 mg én gang dagligt.
English: Second occurrence (same reaction or new reaction)
Danish: Anden hændelse (samme bivirkning eller ny bivirkning)
English: Lenvatinib should be discontinued in the event of nephrotic syndrome.
Danish: Lenvatinib bør seponeres i tilfælde af nefrotisk syndrom.
English: Lenvatinib has not been studied in patients with severe hepatic imparement (Child-Pugh C) and is not recommended for use in these patients.
Danish: Lenvatinib er ikke blevet studeret hos patienter med svært nedsat leverfunktion (Child-Pugh C) og anbefales ikke til brug hos disse patienter.
English: Lenvatinib exposure, based on AUC0-inf data, was 101%, 90%, and 122% of normal for subjects with mild, moderate, and severe renal impairment, respectively.
Danish: Lenvatinib-eksponeringen, baseret på data for AUC0-inf var 101 %, 90 % og 122 % af normalen for personer med hhv. let, moderat og svært nedsat nyrefunktion.
English: Calcium carbonate
Danish: Calciumcarbonat
English: However, in vivo data indicated that non-P450-mediated pathways contributed to a significant portion of the overall metabolism of lenvatinib.
Danish: In vivo-data indikerede imidlertid, at metaboliseringsveje, som ikke var medieret af cytokrom P450, udgjorde en signifikant andel af den samlede lenvatinibmetabolisme.
English: Appropriate measures should be taken to control blood pressure (see section 4.4, Hypertension).
Danish: Passende forholdsregler bør tages for at kontrollere blodtrykket (se pkt.
English: Bleeding in sites other than the brain (e.g. trachea, intra-abdominal, lung) has also been reported.
Danish: Blødning andre steder end hjernen (f.eks. trakealt, intraabdominalt, i lunge) er også blevet rapporteret.
English: There was also a case of acute hepatitis in a patient without liver metastases.
Danish: Der var også et tilfælde af akut hepatitis hos en patient uden levermetastaser.
English: Lenvatinib is not a substrate for OAT1, OAT3, OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K or the bile salt export pump BSEP.
Danish: Lenvatinib er ikke et substrat for OAT1, OAT3, OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K eller galdesalt-eksportpumpen BSEP.
English: Lenvatinib should be discontinued following an arterial thrombotic event.
Danish: Lenvatinib bør seponeres efter en arteriel trombotisk hændelse.
English: Electrocardiograms should be monitored at baseline and periodically during treatment in all patients with particular attention to those with congenital long QT syndrome, congestive heart failure, bradyarrhythmias, and those taking medicinal products known to prolong the QT interval, including Class Ia and III antiarrhythmics.
Danish: Elektrokardiogrammer bør overvåges ved baseline og regelmæssigt i løbet af behandlingen hos alle patienter, særligt hos patienter med medfødt langt QT-syndrom, kongestivt hjertesvigt, bradyarytmier og patienter, der tager lægemidler, der vides at forlænge QT-intervallet, herunder Klasse Ia eller III antiarytmika.
English: Lenvatinib showed minimal or no inhibitory activities toward P-gp-mediated and breast cancer resistance protein (BCRP)-mediated transport activities.
Danish: Lenvatinib viste minimal eller ingen hæmmende aktivitet mod P-gp-medierede og brystkræft-resistent protein (BCRP)-medierede transportaktiviteter.
English: Cardiac dysfunction
Danish: Hjertedysfunktion
English: Blood pressure (BP) should be well controlled prior to treatment with lenvatinib and, if patients are known to be hypertensive, they should be on a stable dose of antihypertensive therapy for at least 1 week prior to treatment with lenvatinib.
Danish: Blodtrykket skal være velkontrolleret før behandling med lenvatinib og hvis patienterne vides at have hypertension, skal de være på en stabil dosis i antihypertensiv behandling i mindst 1 uge før behandling med lenvatinib.
English: The median time to onset was 26 days.
Danish: Mediantiden til indtræden var 26 dage.
English: Efficacy results in DTC patients
Danish: Tabel 6 Virkningsresultater hos DTC-patienter
English: Third occurrence (same reaction or new reaction)
Danish: Tredje hændelse (samme bivirkning eller ny bivirkning)
English: In 452 patients with RAI-refractory DTC, dose reduction and discontinuation were the actions taken for an adverse reaction in 63.1% and 19.5% of patients, respectively.
Danish: Hos 452 patienter med RAI-refraktært DTC var dosisreduktion og seponering de udførte handlinger for en bivirkning hos hhv. 63,1 % og 19,5 % af patienterne.
English: Four (1.5%) subjects treated with lenvatinib attained a CR and 165 subjects (63.2%) had a PR, while no subjects treated with placebo had a CR and 2 (1.5%) subjects had a PR.
Danish: Fire (1,5 %) personer behandlet med lenvatinib opnåede et CR, og 165 personer (63,2 %) havde et PR, mens ingen personer behandlet med placebo havde et CR, og 2 (1,5 %) personer havde et PR.
English: Continue lenvatinib and initiate antihypertensive therapy, if not already receiving
Danish: Fortsæt lenvatinib, og påbegynd antihypertensiv behandling, hvis patienten ikke allerede får det
English: Your doctor may consider stopping LENVIMA if you will be undergoing a major surgical procedure as LENVIMA may affect wound healing.
Danish: Lægen kan overveje at stoppe LENVIMA, hvis du skal igennem en større operation, da LENVIMA kan påvirke sårhelingen.
English: Growth retardation, secondary delay of physical development, and lesions attributable to pharmacologic effects (incisors, femur [epiphyseal growth plate], kidneys, adrenals, and duodenum) were also observed in juvenile rats.
Danish: Vækstretardation, sekundær forsinkelse af fysisk udvikling og læsioner, der kan tilskrives farmakologiske virkninger (incisorer, femur [epifyse-vækstplade], nyrer, binyrer og duodenum) blev også observeret hos juvenile rotter.
English: Elevation of TSH above the upper limit of normal was observed post baseline in 69.6% of lenvatinib-treated patients.
Danish: Forhøjelse af niveauet af TSH over den øvre grænse for det normale blev observeret efter baselinehos 69,6 % af de lenvatinib-behandlede patienter.
English: In the placebo group 0.8% of patients developed renal failure or impairment (0.8% were Grade ≥ 3).
Danish: I placebogruppen udviklede 0,8 % af patienterne nyresvigt eller nedsat nyrefunktion (0,8 % var grad ≥ 3).
English: To dissolve them, pour a tablespoon of water or apple juice into a small glass and put the capsules into the liquid without breaking or crushing them.
Danish: For at opløse dem, hælder du en skefuld vand eller æblejuice i et lille glas og putter kapslerne i væsken uden at dele eller knuse dem.
English: Median was estimated with the Kaplan-Meier method and the 95% confidence interval was constructed with a generalised Brookmeyer and Crowley method.
Danish: Median blev bedømt med Kaplan-Meier-metoden, og 95 % confidencinterval blev udformet med en generaliseret Brookmeyer og Crowley-methode.
English: • changes in urine tests for protein (high) and urinary infections (increased frequency in urination and pain in passing urine)
Danish: • ændringer i urinprøver for protein (høje) og blærebetændelse (øget vandladningshyppighed og smerter ved vandladning
English: Screening for and subsequent treatment of oesophageal varices in patients with liver cirrhosis should be performed as per standard of care before starting treatment with lenvatinib
Danish: Screening for og efterfølgende behandling af øsofageale åreknuder hos patienter med levercirrose skal udføres som standardbehandling, før der indledes behandling med lenvatinib.
English: • If you have or have had an aneurysm (enlargement and weakening of a blood vessel wall) or a tear in a blood vessel wall.
Danish: • har eller har haft et aneurisme (udvidelse og svækkelse af en blodårevæg) eller en rift i en blodårevæg.
English: Hypocalcaemia‡ Hypokalaemia Decreased weight Decreased appetite
Danish: Hypocalcæmi‡ Hypokaliæmi Vægtreduktion Nedsat appetit
English: Posterior reversible encephalopathy syndrome Monoparesis Transient ischaemic attack
Danish: Posteriort reversibelt encefalopatisyndrom Monoparese Transitorisk iskæmisk anfald
English: Lenvatinib was embryotoxic and teratogenic when administered to rats and rabbits (see section 5.3).
Danish: Lenvatinib var embryotoksisk og teratogent ved administration til rotter og kaniner (se pkt.
English: Liver function tests should be monitored before initiation of treatment, then every 2 weeks for the first 2 months and monthly thereafter during treatment.
Danish: Der bør tages leverfunktionsprøver før behandlingen indledes, dernæst hver 2. uge i løbet af de første 2 måneder og derefter månedligt i løbet af behandlingen).
English: Lenvatinib showed minimal or no inhibitory effect on OATP1B3 and MATE2-K. Lenvatinib weakly inhibits MATE1.
Danish: Lenvatinib viste en minimal eller ingen hæmmende virkning på OATP1B3 og MATE2-K. Lenvatinib hæmmer MATE1 svagt.
English: Randomisation was stratified by geographic region (Europe, North America, and Other), prior VEGF/VEGFR-targeted therapy (patients may have received 0 or 1 prior VEGF/VEGFR-targeted therapy), and age (≤65 years or >65 years).
Danish: Randomiseringen blev stratificeret efter geografisk region (Europa, Nordamerika og andet), tidligere VEGF/VEGFR-målrettet behandling (patienter kan have fået 0 eller 1 tidligere VEGF/VEGFRmålrettet behandling) og alder (≤ 65 år eller > 65 år).
English: Systolic BP ≥140 mmHg up to <160 mmHg or diastolic BP ≥90 mmHg up to <100 mmHg
Danish: Systolisk blodtryk ≥ 140 mmHg op til < 160 mmHg eller diastolisk blodtryk ≥ 90 mmHg op til < 100 mmHg
English: The toxicity of lenvatinib was more prominent in younger rats (dosing initiated on PND7) compared with those with dosing initiated on PND21 and mortality and some toxicities were observed earlier in the juvenile rats at 10 mg/kg compared with adult rats administered the same dose level.
Danish: Toksiciteten af lenvatinib var mere fremtrædende hos yngre rotter (doseringen blev påbegyndt på PND7) sammenlignet med de rotter, hvor doseringen blev påbegyndt på PND21 og mortalitet og nogle toksiciteter blev observeret tidligere hos juvenile rotter ved 10 mg/kg sammenlignet med voksne rotter, der blev administreret ved det samme doseringsniveau.
English: No adjustment of starting dose is required on the basis of race (see section 5.2).
Danish: Ingen dosisjustering af startdosis er nødvendig på basis af racen (se pkt.
English: Close monitoring of overall safety is recommended in these patients (see sections 4.4 and 5.2).
Danish: Tæt monitorering af overordnet sikkerhed anbefales hos disse patienter (see pkt.
English: Blood pressure should be well controlled prior to treatment with lenvatinib, and should be regularly monitored during treatment (see section 4.4).
Danish: Blodtrykket bør være velkontrolleret før behandling med lenvatinib, og det bør overvåges regelmæssigt under behandlingen (se pkt.
English: When administered with food to healthy subjects, peak plasma concentrations are delayed by 2 hours.
Danish: Når lenvatinib administreres sammen med mad til raske personer, udsættes de maksimale plasmakoncentrationer med 2 timer.
English: • The other ingredients are calcium carbonate, mannitol, microcrystalline cellulose, hydroxypropylcellulose, low-substituted hydroxypropyl cellulose, talc.
Danish: • Øvrige indholdsstoffer: calciumcarbonat, mannitol, mikrokrystallinsk cellulose, hydroxypropylcellulose, lavsubstitueret hydroxypropylcellulose, talcum.
English: Patients with worse hepatic impairment and/or greater liver tumour burden at baseline had a higher risk of developing hepatic encephalopathy and hepatic failure.
Danish: Patienter med alvorligst nedsat leverfunktion og/eller større tumorbyrde i leveren ved baseline havde en større risiko for at udvikle hepatisk encefalopati og nedsat leverfunktion.
English: Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4), in addition to other proangiogenic and oncogenic pathway-related RTKs including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4, the platelet derived growth factor (PDGF) receptor PDGFRα, KIT, and RET.
Danish: Lenvatinib er en receptortyrosinkinase (RTK)-hæmmer, der selektivt hæmmer kinaseaktiviteterne af vaskulærendotelvækstfaktor (VEGF)-receptorer VEGFR1 (FLT1), VEGFR2 (KDR) og VEGFR3 (FLT4) foruden andre proangiogene og onkogene reaktionsvejsrelaterede RTK'er, herunder fibroblastvækstfaktor (FGF)-receptorer FGFR1, 2, 3 og 4, trombocytderiveret vækstfaktor (PDGF)receptor PDGFRα, KIT og RET.
English: Females had a higher incidence of hypertension, fatigue, ECG QT prolongation and alopecia.
Danish: Kvinder havde en højere forekomst af hypertension, træthed, EKG QT-forlængelse og alopecia.
English: Increased aspartate aminotransferase ‡
Danish: Forhøjet niveau af aspartataminotransferase‡
English: Neutropenia includes neutropenia and decreased neutrophil count decreased.
Danish: Neutropeni omfatter neutropeni og nedsat neutrocyttal.
English: Excluding laboratory abnormalities judged to be nonlife-threatening, which should be managed as Grade 3.
Danish: Eksklusiv laboratorieanomalier, der bedømmes til ikke at være livstruende, og som skal behandles som grad 3.
English: However, testicular (hypocellularity of the seminiferous epithelium) and ovarian changes (follicular atresia) were observed in repeated-dose toxicity studies in animals at exposures 11 to 15 times (rat) or 0.6 to 7 times (monkey) the anticipated clinical exposure (based on AUC) at the maximum tolerated human dose.
Danish: Testikelændringer (hypocellularitet af det seminiferøse epitel) samt ovarieændringer (follikulær atresi) blev imidlertid observeret i toksicitetsstudier med gentagne doser hos dyr ved eksponeringer, der var 11 til 15 gange (rotte) eller 0,6 til 7 gange (abe) den forventede kliniske eksponering (baseret på AUC) ved den maksimalt tolererede humane dosis.
English: • need to have a surgical procedure.
Danish: • skal igennem en operation.
English: Interrupt until resolved to Grade 0-1 or baselined
Danish: Afbryd indtil bivirkning har fortaget sig til grad 0-1 eller baselined
English: • changes in blood test results for magnesium (low), cholesterol (high) and thyroid stimulating hormone (high)
Danish: • ændrede blodprøveresultater magnesium i blodet (lave), kolesterol (høje) og skjoldbruskkirtel stimulerende hormon (høje)
English: Lenvatinib should be used with caution in such patients, given the reduced tolerability of lenvatinib in Asian and elderly patients (see section 4.8, Other special populations).
Danish: Lenvatinib bør anvendes med forsigtighed hos sådanne patienter, i lyset af den reducerede tolerabilitet af lenvatinib hos asiatiske og ældre patienter (se pkt.
English: 4.7 Effects on ability to drive and use machines Lenvatinib has a minor influence on the ability to drive and use machines, due to undesirable effects such as fatigue and dizziness.
Danish: Lenvatinib påvirker i mindre grad evnen til at føre motorkøretøj og betjene maskiner på grund af bivirkninger som træthed og svimmelhed.
English: Mortality was the dose-limiting toxicity in juvenile rats in which dosing was initiated on postnatal day (PND) 7 or PND21 and was observed at exposures that were respectively 125- or 12-fold lower compared with the exposure at which mortality was observed in adult rats, suggesting an increasing sensitivity to toxicity with decreasing age.
Danish: Mortalitet var den dosisbegrænsende toksicitet hos juvenile rotter, hvor dosering blev påbegyndt på den postnatale dag (PND) 7 eller PND21, og blev observeret ved eksponeringer, der var hhv. 125 eller 12 gange lavere sammenlignet med eksponeringen, hvor der blev observeret mortalitet hos voksne rotter, hvilket tyder på en øget følsomhed i forhold til toksicitet ved faldende alder.
English: Hazard ratio is for lenvatinib vs. sorafenib, based on a Cox model including treatment group as a factor.
Danish: Skæringsdato for data: 13. november 2016. a Hazard ratio er for lenvatinib vs. Sorafenib, baseret på en Cox model, der inkluderer behandlingsgruppe som en faktor.
English: Similarly, although not studied directly, the MOA for proteinuria is postulated to be mediated by downregulation of VEGFR1 and VEGFR2 in the podocytes of the glomerulus.
Danish: På samme måde postuleres det, selvom det ikke er blevet undersøgt direkte, at virkningsmekanismen for proteinuri medieres via VEGFR1 og VEGFR2 i podocytterne i glomerulus.
English: Grade 4*
Danish: Grad 4*
English: Cardiac failure Prolonged electrocardiogram QT Decreased ejection fraction
Danish: Hjertesvigt Forlænget elektrokardiogram QT Reduceret uddrivningsfraktion
English: In those patients with a normal TSH at baseline, elevation of TSH level above 0.5 mU/L was observed post baseline in 57% of lenvatinib-treated patients as compared with 14% of placebo-treated patients.
Danish: Hos patienterne med en normal TSH ved baseline blev der observeret en forhøjelse af niveauet of TSH over 0,5 mE/l efter baseline hos 57 % af de lenvatinibbehandlede patienter sammenlignet med 14 % af de placebobehandlede patienter.
English: LENVIMA is indicated as monotherapy for the treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine (RAI).
Danish: LENVIMA er indiceret som monoterapi til behandling af voksne patienter med progressiv, lokalt fremskreden eller metastatisk, differentieret (papillært/follikulært/Hürthle-celle) tyreoideakarcinom (DTC), refraktært over for radioaktivt jod (RAI).
English: Mild to moderate adverse reactions (e.g., Grade 1 or 2) generally do not warrant interruption of lenvatinib, unless intolerable to the patient despite optimal management.
Danish: Lette til moderate bivirkninger (f.eks. grad 1 eller 2) kræver normalt ikke afbrydelse af lenvatinib, medmindre de ikke kan tolereres af patienten trods optimal behandling.
English: may be restarted once adequate wound healing is established.
Danish: LENVIMA kan startes igen, når det vurderes, at såret er helet tilstrækkeligt.
English: • feeling numb or weak on one side of your body, severe headache, seizure, confusion, difficulty talking, vision changes or feeling dizzy - these may be signs of a stroke, bleeding on your brain, or the effect on your brain of a severe increase in blood pressure.
Danish: • følelsesløshed eller svækkelse i den ene side af kroppen, svær hovedpine, krampeanfald, forvirring, talebesvær, synsændringer eller svimmelhedsfølelse - dette kan være tegn på et slagtilfælde, blødning i hjernen eller virkningen af en kraftig stigning i blodtrykket på hjernen.
English: European Knowledge Centre, Mosquito Way, Hatfield, Herfordshire, AL10 9SN, United Kingdom Or
Danish: Eisai Manufacturing Ltd European Knowledge Centre, Mosquito Way, Hatfield, Hertfordshire, AL10 9SN, Storbritannien
English: • Prior treatments: hepatectomy (28%), radiotherapy (11%), loco-regional therapies including transarterial (chemo)embolisation (52%), radiofrequency ablation (21%) and percutaneous ethanol injection (4%)
Danish: • Tidligere behandlinger: hepatektomi (28 %), strålebehandling (11 %), lokole/regionale behandlinger inclusive transarteriel (kemo) embolisering (52 %), radiofrekvensablation (21 %)
English: Renal failure cases n, †
Danish: Tilfælde af nyresvigt n , †
English: In subgroup analyses by stratification factors (presence or absence of MPVI or EHS or both, ECOG PS 0 or 1, BW <60 kg or ≥60 kg and region) the HR consistently favoured lenvatinib over sorafenib, with the exception of Western region [HR of 1.08 (95% CI 0.82, 1.42], patients without EHS [HR of 1.01 (95% CI 0.78, 1.30)] and patients without MPVI, EHS or both [HR of 1.05 (0.79, 1.40)].
Danish: I subgruppe-analyser med stratificerings-faktorer (tilstedeværelse eller fravær af MPVI eller EHS eller begge, ECOG PS 0 eller 1, kropsvægt < 60 kg eller ≥ 60 kg og region) favoriserede HR konstant lenvatinib frem for sorafenib med undtagelse af den vestlige region [HR på 1,08 (95 % CI 0,82; 1,42], patienter uden EHS [HR på 1,01 (95 % CI 0,78; 1,30)] og patienter uden MPVI, EHS eller begge [HR på 1,05 (0,79; 1,40)].
English: • yellow skin or yellowing of the whites of the eyes (jaundice) or drowsiness, confusion, poor concentration - these may be signs of liver problems.
Danish: • gul hud eller gulfarvning af det hvide i øjnene (gulsot) eller døsighed, forvirring eller dårlig koncentrationsevne - det kan være tegn på leverproblemer.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/15/1002/001 (Pack size of 30 hard capsules) EU/1/15/1002/003 (Pack size of 60 hard capsules) EU/1/15/1002/004 (Pack size of 90 hard capsules) 13.
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/15/1002/001 (pakningsstørrelse på 30 hårde kapsler) EU/1/15/1002/003 (pakningsstørrelse på 60 hårde kapsler) EU/1/15/1002/004 (pakningsstørrelse på 90 hårde kapsler) 13.
English: In the repeated-dose toxicity studies (up to 39 weeks), lenvatinib caused toxicologic changes in various organs and tissues related to the expected pharmacologic effects of lenvatinib including glomerulopathy, testicular hypocellularity, ovarian follicular atresia, gastrointestinal changes, bone changes, changes to the adrenals (rats and dogs), and arterial (arterial fibrinoid necrosis, medial degeneration, or haemorrhage) lesions in rats, dogs, and cynomolgus monkeys.
Danish: I toksicitetsstudierne med gentagne doser (op til 39 uger) forårsagede lenvatinib toksikologiske ændringer i forskellige organer og væv relateret til de forventede farmakologiske virkninger af lenvatinib, herunder glomerulopati, testikulær hypocellularitet, follikular atresi af ovarierne, mavetarm-ændringer, knogleændringer, ændringer af binyrerne (rotter og hunde) og arterielle (arteriel fibrinoid nekrose, medial degeneration eller blødning) læsioner hos rotter, hunde og cynomolgus-aber.
English: • underactive thyroid (tiredness, weight gain, constipation, feeling cold, dry skin)
Danish: • underaktiv skjoldbruskkirtel (træthed, vægtøgning, forstoppelse, kuldefølelse, tør hud)
English: • An enlargement and weakening of a blood vessel wall or a tear in a blood vessel wall (aneurysms and artery dissections).
Danish: • en udvidelse og svækkelse af en blodårevæg eller en rift i en blodårevæg (aneurismer og arterielle dissektioner).
English: In vitro, the lenvatinib blood-to-plasma concentration ratio ranged from 0.589 to 0.608 (0.110 μg/mL, mesylate).
Danish: In vitro var lenvatinib-blod-til-plasma-koncentrationsforholdet i intervallet fra 0,589 til 0,608 (0,1 - 10 μg/ml, mesilat).