FrancophonIA/ELRC3.0 huggingface dataset:
English: Seroquel Prolong® 50 mg Retardtabletten, Seroquel Prolong® 150 mg Retardtabletten, Seroquel Prolong® 200 mg Retardtabletten, Seroquel Prolong® 300 mg Retardtabletten, Seroquel Prolong® 400 mg Retardtabletten
Croatian: Prolong® 50 mg Retardtabletten, Seroquel Prolong® 150 mg Retardtabletten, Seroquel Prolong® 200 mg Retardtabletten, Seroquel Prolong® 300 mg Retardtabletten, Seroquel Prolong® 400 mg Retardtabletten
English: See Section 4.4.
Croatian: Vidjeti dio 4.4.
English: (22) Decreased haemoglobin to ≤13 g/dL (8.07 mmol/L) males, ≤12 g/dL (7.45 mmol/L) females on at least one occasion occurred in 11% of quetiapine patients in all trials including open label extensions.
Croatian: 22. Sniženje razine hemoglobina na ≤ 13 g/dL (8.07 mmol/L) za muškarce, te na ≤ 12 g/dL (7.45 mmol/L) za žene, barem jednom, se pojavilo u 11 % bolesnika koji su uzimali kvetiapin u svim studijama uključujući i produžetke otvorenog tipa.
English: (5) Calculation of Frequency for these ADR's have only been taken from postmarketing data with the immediate release formulation of quetiapine.
Croatian: Izračun učestalosti ovih nuspojava je temeljen samo na osnovu podataka iz razdoblja nakon stavljanja lijeka u promet za formulaciju tableta kvetiapina s trenutnim oslobađanjem djelatne tvari.
English: Long-term efficacy and safety in patients with MDD has not been evaluated as add-on therapy, however long-term efficacy and safety has been evaluated in adult patients as monotherapy (see below).
Croatian: Dugoročna djelotvornost i sigurnost primjene u bolesnika s velikim depresivnim poremećajem nije ispitivana kao dodatna terapija, međutim dugoročna djelotvornost i sigurnost primjene su ispitivane kod odraslih bolesnika kao monoterapija (vidjeti niže).
English: Seroquel 4-Day Starterpack contains 6 tablets Seroquel 25 mg, 3 tablets Seroquel 100 mg and 1 tablet Seroquel 200 mg
Croatian: Seroquel 4-dnevno početno pakiranje sadržava 6 tableta Seroquel 25 mg, 3 tablete Seroquel 100 mg i 1 tabletu Seroquel 200 mg
English: Like all medicines, Seroquel can cause side effects, although not everybody gets them.
Croatian: Moguće nuspojave Kao i svi drugi lijekovi, Seroquel može uzrokovati nuspojave iako se one neće javiti kod svakoga.
English: Pack sizes of 10, 30, 50, 60 and 100 tablets are registered for all strengths.
Croatian: Za sve jačine registrirana su pakiranja od 10, 30, 50, 60 i 100 tableta.
English: Seizure 1, Restless legs syndrome, Tardive dyskinesia 1, 5,
Croatian: 1, sindrom napadaj nemirnih nogu, tardivna diskinezija1, 5,
English: Seroquel XR should be administered prior to bedtime.
Croatian: Seroquel XR potrebno je uzeti prije spavanja.
English: Elderly patients with dementia-related psychosis Quetiapine is not approved for the treatment of dementia-related psychosis.
Croatian: Kvetiapin nije odobren za liječenje psihoze povezane s demencijom.
English: • Combination of fever, flu-like symptoms, sore throat, or any other infection with very low white blood cell count, a condition called agranulocytosis.
Croatian: • kombinacija vrućice, simptoma nalik gripi, grlobolje ili bilo koja druga infekcija praćena vrlo niskim brojem bijelih krvnih stanica - to se stanje naziva agranulocitoza • blokada crijeva
English: As with other antipsychotics, Seroquel should be used with caution in the elderly, especially during the initial dosing period.
Croatian: Kao i u slučaju ostalih antipsihotika, starijim bolesnicima Seroquel se mora davati s oprezom, naročito tijekom početnog razdoblja doziranja.
English: For add-on treatment of major depressive episodes in MDD:
Croatian: Za dodatno liječenje velikih depresivnih epizoda u velikom depresivnom poremećaju:
English: Talk to your doctor or pharmacist before taking Seroquel XR if:
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete Seroquel XR:
English: Seroquel contains lactose which is a type of sugar.
Croatian: Seroquel sadrži laktozu, jednu vrstu šećera.
English: Other medicines and Seroquel Tell your doctor if you are taking or have recently taken any other medicines .
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli bilo koje druge lijekove.
English: Dysphagia (See section 4.8 ) has been reported with quetiapine.
Croatian: Disfagija (vidjeti dio 4.8) je zabilježena tijekom liječenja kvetiapinom.
English: The mean last week median dose of Seroquel in responders was approximately 600 mg/day and approximately 85% of the responders were in the dose range of 400 to 800 mg/day.
Croatian: Medijan doze Seroquela primijenjene u zadnjem tjednu u bolesnika koji su odgovorili na liječenje iznosio je otprilike 600 mg dnevno i otprilike 85% bolesnika koji su odgovorili na liječenje primali su doze u rasponu od 400 do 800 mg dnevno.
English: For preventing recurrence of manic, mixed or depressive episodes in bipolar disorder, patients who have responded to quetiapine for acute treatment of bipolar disorder should continue therapy at the same dose.
Croatian: Za sprječavanje ponovne pojave maničnih, mješovitih ili depresivnih epizoda u bipolarnom poremećaju, u bolesnika koji su odgovorili na kvetiapin u akutnom liječenju bipolarnog poremećaja, potrebno je nastaviti liječenje s uzimanjem jednake doze.
English: From animal studies it appears that quetiapine can induce cytochrome P450 enzymes.
Croatian: Iz ispitivanja na životinjama, pokazalo se da kvetiapin može inducirati enzime citokroma
English: Quetiapine treatment was associated with dose-related decreases in thyroid hormone levels.
Croatian: Liječenje kvetiapinom je povezano s o dozi ovisnim smanjenjem razine hormona štitnjače.
English: somnolence headache, Extrapyramidal symptoms1, 21
Croatian: somnolencija glavobolja, ekstrapiramidni simptomi1, 21
English: Pancreatitis Intestinal obstruction/Ileus
Croatian: pankreatitis1, opstrukcija crijeva/ileus
English: Also caution should be exercised when quetiapine is prescribed either with medicines known to increase QT interval or with concomitant neuroleptics, especially in the elderly, in patients with congenital long QT syndrome, congestive heart failure, heart hypertrophy, hypokalaemia or hypomagnesaemia (see section 4.5).
Croatian: Također je nužan oprez pri propisivanju kvetiapina s lijekovima za koje je poznato da produžuju QT interval te pri istodobnoj primjeni neuroleptika, naročito u starijih, u bolesnika s: kongenitalnim sindromom produljenog QT intervala, kongestivnim srčanim zatajenjem, hipertrofijom srca, hipokalijemijom ili hipomagnezijemijom (vidjeti dio 4.5).
English: Seroquel XR should not be taken if you are breast-feeding.
Croatian: Seroquel XR se ne smije uzimati ukoliko dojite.
English: In vitro investigations established that CYP3A4 is the primary enzyme responsible for cytochrome P450 mediated metabolism of quetiapine.
Croatian: In vitro ispitivanja ustanovila su da je CYP3A4 osnovni enzim odgovoran za metabolizam kvetiapina posredovan citokromom P450.
English: It is important that any change in the inducer is gradual, and if required, replaced with a non-inducer (e.g. sodium valproate) (see section 4.4).
Croatian: Važno je da se bilo kakva promjena u doziranju induktora provodi postupno, te ako je neophodno, zamjeni s lijekom koji nije induktor (npr. natrijev valproat) (vidjeti dio 4.4).
English: A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel XR to be stopped and/or treatment to be given.
Croatian: • vrućicu, simptome nalik gripi, grlobolju ili bilo koju drugu infekciju jer to može biti posljedica vrlo niskog broja bijelih krvnih stanica, zbog čega ćete možda morati prestati uzimati Seroquel XR i/ili primiti liječenje
English: (see section 4.8)
Croatian: (vidjeti dio 4.8).
English: Keep out of the reach and sight of children.
Croatian: I DOHVATA DJECE Čuvati izvan dohvata i pogleda djece.
English: Weight gain has been reported in patients who have been treated with quetiapine, and should be monitored and managed as clinically appropriate as in accordance with utilized antipsychotic guidelines (See Sections 4.8 and 5.1).
Croatian: Povećanje tjelesne težine je prijavljeno kod bolesnika liječenih kvetiapinom i mora se nadzirati te poduzeti prikladne kliničke mjere, u skladu sa smjernicama za primjenu antipsihotika (vidjeti dijelove 4.8 i 5.1).
English: In shorter-term placebo controlled clinical studies of patients with major depressive episodes in bipolar disorder an increased risk of suicide-related events was observed in young adult patients (younger than 25 years of age) who were treated with quetiapine as compared to those treated with placebo (3.0% vs. 0%, respectively).
Croatian: U kratkoročnim placebom kontroliranim kliničkim ispitivanjima bolesnika s velikim depresivnim epizodama u bipolarnom poremećaju primijećen je povećani rizik od događaja povezanih sa suicidom u mlađih odraslih bolesnika (mlađi od 25 godina) koji su uzimali kvetiapin u usporedbi s onima liječenim placebom (3,0% u odnosu na 0%).
English: Switching from Seroquel immediate-release tablets:
Croatian: Prebacivanje sa Seroquel tableta s trenutnim oslobađanjem na Seroquel XR tablete s produljenim oslobađanjem:
English: If you stop taking Seroquel XR
Croatian: Ako prestanete uzimati Seroquel XR
English: MARKETING AUTHORISATION HOLDER MARKETING AUTHORISATION NUMBER(S) DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 10.
Croatian: DATUM PRVOG ODOBRENJA/DATUM OBNOVE ODOBRENJA
English: What Seroquel XR contains
Croatian: Što Seroquel XR sadrži
English: The frequencies of adverse events are ranked according to the following: Very common (≥1/10), common (≥1/100, <1/10), uncommon (≥1/1000, <1/100, rare (≥1/10,000, <1/1000), very rare (<1/10,000), and not known
Croatian: Učestalost nuspojava klasificirana je na sljedeći način: vrlo često (≥1/10), često (≥1/100, <1/10), manje često (≥1/1000, <1/100), rijetko (≥1/10 000, <1/1000) i vrlo rijetko (<1/10 000).
English: In a clinical trial to evaluate the cataractogenic potential of Seroquel (200-800 mg/day) versus risperidone (2-8 mg/day) in patients with schizophrenia or schizoaffective disorder, the percentage of patients with increased lens opacity grade was not higher in Seroquel (4%) compared with risperidone (10%), for patients with at least 21 months of exposure.
Croatian: U kliničkom ispitivanju u kojem je procjenjivan kataraktogeni potencijal Seroquela (200-800 mg/dan) u odnosu na risperidon (2-8 mg) kod bolesnika sa shizofrenijom ili shizoafektivnim poremećajem, postotak bolesnika sa povećanim stupnjem zamućenja leće nije bio viši sa Seroquelom (4%) u usporedbi sa risperidonom (10%) kod bolesnika s barem 21 mjesecom izloženosti.
English: The daily dose at the start of therapy is 50 mg on Day 1 and 2, and 150 mg on Day 3 and 4.
Croatian: Dnevna doza na početku terapije je 50 mg prvi i drugi dan, i 150 mg treći i četvrti dan.
English: Calculation of Frequency for these ADR's have been taken from postmarketing data only.
Croatian: Izračun učestalosti ovih nuspojava je temeljen samo na osnovu podataka iz razdoblja nakon stavljanja lijeka u promet.
English: In an interaction study in healthy volunteers, concomitant administration of quetiapine (dosage of 25 mg) with ketoconazole, a CYP3A4 inhibitor, caused a 5-to 8-fold increase in the AUC of quetiapine.
Croatian: U ispitivanju interakcija provedenom na skupini zdravih dobrovoljaca, istodobna primjena kvetiapina (u dozi od 25 mg) s ketokonazolom, inhibitorom CYP3A4, uzrokovala je peterostruko do osmostruko povećanje površine ispod krivulje koncentracija-vrijeme za kvetiapin (AUC; od engl.
English: The following table summarises ADRs that occur in a higher frequency category in children and adolescents patients (10-17 years of age) than in the adult population or ADRs that have not been identified in the adult population.
Croatian: U slijedećoj tablici su prikazane nuspojave koje su se u djece i adolescenata (10-17 godina) javljale s većom učestalosti nego u odraslih i nuspojave koje nisu zabilježene u odraslih.
English: An increase in the rate of dysphagia with quetiapine vs. placebo was only observed in the clinical trials in bipolar depression.
Croatian: Povećanje stope disfagije uzrokovane kvetiapinom u odnosu na placebo je primijećeno samo u kliničkim ispitivanjima u liječenju bipolarne depresije.
English: How to take Seroquel XR
Croatian: Kako uzimati Seroquel XR
English: • Increases in the amount of liver enzymes measured in the blood
Croatian: • povećanja količine jetrenih enzima u krvi
English: These reports often occurred in the setting of tachycardia, dizziness, orthostatic hypotension, and/or underlying cardiac/respiratory disease.
Croatian: Ovi slučajevi su se često pojavljivali uz postojeću tahikardiju, omaglicu, ortostatsku hipotenziju, i/ili podležeću srčanu/respiratornu bolest.
English: Syncope
Croatian: sinkopa
English: Thoughts of suicide and worsening of your depression If you are depressed you may sometimes have thoughts of harming or killing yourself.
Croatian: Ako patite od depresije, ponekad Vam se mogu javiti misli o samoozljeđivanju ili samoubojstvu.
English: In some patients, a worsening of more than one of the metabolic factors of weight, blood glucose and lipids was observed in clinical studies (See Section 4.4).
Croatian: Kod nekih bolesnika, u kliničkim studijama primijećena su pogoršanja više od jednog metaboličkog faktora težine, glukoze u krvi i lipida (vidjeti dio 4.4).
English: Quetiapine is extensively metabolised by the liver, with parent compound accounting for less than 5% of unchanged drug-related material in the urine or faeces, following the administration of radiolabelled quetiapine.
Croatian: Kvetiapin se opsežno metabolizira u jetri pa nakon uzimanja radioobilježenog kvetiapina, ishodišni spoj čini manje od 5% lijeka u nepromijenjenom obliku u urinu i fecesu.
English: The daily dose at the start of therapy is 300 mg on Day 1 and 600 mg on Day 2.
Croatian: Dnevna doza na početku liječenja iznosi 300 mg prvi dan i 600 mg drugi dan.
English: What Seroquel XR is and what it is used for
Croatian: Što se nalazi u ovoj uputi: Što je Seroquel XR i za što se koristi
English: The incidence of relapse was 14.2% for Seroquel XR treated patients and 34.4% for placebo-treated patients.
Croatian: Incidencija relapsa u ispitanika koji su uzimali Seroquel XR je bila 14,2%, a kod bolesnika koji su uzimali placebo 34,4%.
English: For preventing recurrence of manic, mixed or depressive episodes in bipolar disorder, patients who have responded to Seroquel XR for acute treatment of bipolar disorder should continue on Seroquel XR at the same dose administered at bedtime.
Croatian: Za sprječavanje ponovne pojave maničnih, mješovitih ili depresivnih epizoda u bipolarnom poremećaju, u bolesnika kod koji su odgovorili na Seroquel XR u akutnom liječenju bipolarnog poremećaja, potrebno je nastaviti liječenje s uzimanjem jednake doze Seroquela XR prije spavanja.
English: On the basis of this, concomitant use of quetiapine with CYP3A4 inhibitors is contraindicated.
Croatian: Na osnovi toga, kontraindicirana je istodobna uporaba kvetiapina s CYP3A4
English: The mean dose of Seroquel XR was 160 mg/day.
Croatian: Seroquela XR bila je 160 mg/dnevno.
English: • If you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel XR (see section 6: Further information)
Croatian: • ako ste alergični (preosjetljivi) na kvetiapin ili bilo koji drugi sastojak Seroquela XR (naveden u dijelu 6.) • ako uzimate bilo koji od niže navedenih lijekova:
English: A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel to be stopped and/or treatment to be given.
Croatian: • vrućicu, simptome nalik gripi, grlobolju ili bilo koju drugu infekciju jer to može biti posljedica vrlo niskog broja bijelih krvnih stanica, zbog čega ćete možda morati prestati uzimati Seroquel i/ili primiti liječenje
English: 1 blister containing 6 x 25 mg and 2 x 100 mg tablets
Croatian: 1 blister koji sadrži 6 x 25 mg i 2 x 100 mg tablete
English: Interactions See also section 4.5
Croatian: Interakcije Vidjeti i dio 4.5.
English: In the treatment of moderate to severe manic episodes, Seroquel demonstrated superior efficacy to placebo in reduction of manic symptoms at 3 and 12 weeks, in two monotherapy trials.
Croatian: U liječenju umjerenih do teških maničnih epizoda u dva monoterapijska ispitivanja, Seroquel je pokazao superiornu djelotvornost nad placebom u smanjenju maničnih simptoma u trećem i dvanaestom tjednu.
English: In the schizophrenia study, the difference in LS mean change from baseline in PANSS total score (active minus placebo) was -8.16 for Seroquel 400 mg/day and -9.29 for Seroquel 800 mg/day.
Croatian: U ispitivanju shizofrenije, razlika u LS srednjoj vrijednosti promjene u odnosu na početnu vrijednost ukupnog rezultata bodovanja PANSS ljestvice (djelatna tvar minus placebo) bila je -8,16 za Seroquel 400 mg dnevno i -9,29 za Seroquel 800 mg dnevno.
English: Based on adverse event reports of metabolic syndrome from all clinical trials with quetiapine.
Croatian: Temeljeno na prijavama štetnog događaja metaboličkog sindroma iz svih kliničkih ispitivanja s kvetiapinom.
English: HDL cholesterol: <40 mg/dL (1.025 mmol/L) males; <50 mg/dL (1.282 mmol/L) females at any time.
Croatian: 17. HDL kolesterol u bilo kojem trenutku: < 40 mg/dL (1,025 mmol/L) muškarci; < 50 mg/dL (1,282 mmol/L) žene.
English: 20 tablets
Croatian: 20 tableta
English: • Seroquel can be taken with or without food.
Croatian: • Seroquel tse može uzimati uz obrok ili bez obroka.
English: INFORMATION IN BRAILLE Seroquel 100 mg (or 150 mg, or 200 mg or 300 mg)
Croatian: 16. PODACI NA BRAILLEOVOM PISMU Seroquel 100 mg (ili 150 mg, ili 200 mg, ili 300 mg)
English: In three placebo-controlled clinical trials, in patients with schizophrenia, using variable doses of quetiapine, there were no differences between the Seroquel and placebo treatment groups in the incidence of EPS or concomitant use of anticholinergics.
Croatian: U tri placebom kontrolirana klinička ispitivanja, u bolesnika sa shizofrenijom koji su primali različite doze kvetiapina, nije postojala razlika u incidenciji EPS-a ili potrebi za istodobnom primjenom antikolinergika među skupinama u kojima su bolesnici primali Seroquel ili placebo.
English: The primary outcome variable in the placebo-controlled trial was change from baseline to final assessment in the PANSS total score.
Croatian: Varijabla koja se u placebo kontroliranom ispitivanju smatrala primarnim ishodom, bila je promjena u završnoj u odnosu na ishodnu procjenu na PANSS ljestvici, odnosno promjena u ukupnom bodovnom rezultatu postignutom prije i nakon liječenja.
English: Hyperprolactina emia decreases in total T4 decreases in free T4 decreases in total T3 increases in TSH
Croatian: smanjenja razine ukupnog T4 smanjenja razine slobodnog smanjenja razine ukupnog T324,
English: A 6-week, randomised, study of lithium and SEROQUEL XR versus placebo and SEROQUEL XR in adult patients with acute mania indicated that the combination of SEROQUEL XR with lithium leads to more adverse events (63% versus 48% in SEROQUEL XR in combination with placebo).
Croatian: naspram placeba i lijeka Seroquel XR u odraslih bolesnika s akutnom manijom, ukazalo je na to da kombinacija lijeka Seroquel XR i litija uzrokuje više štetnih događaja (63% naspram 48% kod primjene lijeka Seroquel XR u kombinaciji s placebom).
English: However in two 10-week placebo controlled quetiapine studies in the same patient population (n=710; mean age: 83 years; range: 56-99 years) the incidence of mortality in quetiapine treated patients was 5.5% versus 3.2% in the placebo group.
Croatian: Međutim, u dva desetotjedna ispitivanja s kvetiapinom u kojem je placebo korišten kao kontrola, u istoj populaciji bolesnika (n=710; prosječna starost: 83 godine, raspon: 56-99 godina), incidencija smrtnih ishoda u skupini bolesnika koji su uzimali kvetiapin iznosila je 5,5% u usporedbi s 3,2% u skupini koja je primala placebo.
English: The estimated risks of relapse after 6 months treatments was 14.3% for the Seroquel XR treatment group compared to 68.2% for placebo.
Croatian: Nakon 6 mjeseci liječenja, procijenjeni rizik od relapsa osnovne bolesti u skupini liječenoj Seroquelom XR iznosio je 14,3%, a u bolesnika liječenih placebom 68,2%.
English: In a 6-week, randomised, study of lithium and SEROQUEL XR versus placebo and SEROQUEL XR in adult patients with acute mania, a higher incidence of extrapyramidal related events (in particular tremor), somnolence, and weight gain were observed in the lithium add-on group compared to the placebo add-on group (see section 5.1).
Croatian: U šestotjednom randomiziranom ispitivanju u kojem se uspoređivala primjena litija i lijeka Seroquel XR naspram placeba i lijeka Seroquel XR u odraslih bolesnika s akutnom manijom, opažena je veća incidencija ekstrapiramidnih događaja (osobito tremora), somnolencije i povećanja tjelesne težine u skupini kojoj je dodavan litij u odnosu na skupinu kojoj je dodavan placebo (vidjeti dio 5.1).
English: If you take more Seroquel XR than prescribed by your doctor, you may feel sleepy, feel dizzy and experience abnormal heart beats.
Croatian: Uzmete li više Seroquela nego li Vam je propisao liječnik, možete osjetiti pospanost, omaglicu i nepravilne otkucaje srca.
English: In the continuation phase in two of these studies, it was demonstrated that long-term treatment, of patients who responded on Seroquel IR 300 or 600 mg, was efficacious compared to placebo treatment with respect to depressive symptoms, but not with regard to manic symptoms.
Croatian: U nastavku dvaju od navedenih ispitivanja, pokazano je da je, kod bolesnika koji su imali klinički odgovor na Seroquel 300 ili 600 mg tablete s trenutnim oslobađanjem, dugotrajno liječenje u usporedbi s placebom djelotvorno u liječenju simptoma depresije, ali ne i simptoma manije.
English: Cardiomyopathy and myocarditis have been reported in clinical trials and during the post-marketing experience, however, a causal relationship to quetiapine has not been established.
Croatian: U kliničkim ispitivanjima i u razdoblju nakon stavljanja lijeka u promet prijavljeni su kardiomiopatija i miokarditis; međutim, nije utvrđena njihova uzročna povezanost s kvetiapinom.
English: Day 2
Croatian: Tablica 2
English: The pharmacokinetics of quetiapine were not altered following co-administration with cimetidine.
Croatian: Farmakokinetika kvetiapina nije se promijenila nakon istodobne primjene s cimetidinom.
English: The same precautions observed when treating patients with major depressive episodes should therefore be observed when treating patients with other psychiatric disorders.
Croatian: Pri liječenju bolesnika s drugim psihijatrijskim poremećajima moraju se, stoga, poduzeti iste mjere opreza kao kod liječenja bolesnika s velikim depresivnim epizodama.
English: Seroquel should not be taken if you are breast-feeding.
Croatian: Seroquel se ne smije uzimati ukoliko dojite.
English: 1 blister containing 6 x 25mg, 3 x 100mg and 1 x 200mg tablets
Croatian: 1 blister koji sadrži 6 x 25mg, 3 x 100mg i 1 x 200 mg tablete
English: The safety results showed a higher incidence of extrapyramidal symptoms reported in 16.8% of patients in the lithium add-on group and 6.6% in the placebo add-on group, the majority of which consisted of tremor, reported in 15.6% of the patients in the lithium add-on group and 4.9% in the placebo add-on group.
Croatian: Rezultati sigurnosti primjene pokazali su veću incidenciju ekstrapiramidnih simptoma, koji su prijavljeni u 16,8% bolesnika u skupini kojoj je dodavan litij i u 6,6%
English: Seroquel XR was dosed in the range of 400 to 800 mg/day and the mean dose was approximately 600 mg/day.
Croatian: Korištene su doze Seroquela XR u rasponu od 400 do 800 mg dnevno, a srednja je doza iznosila otprilike 600 mg dnevno.