FrancophonIA/ELRC3.0 huggingface dataset:
English: Kaletra has been shown in vivo to induce its own metabolism and to increase the biotransformation of some medicinal products metabolised by cytochrome P450 enzymes (including CYP2C9 and CYP2C19) and by glucuronidation.
Croatian: Utvrđeno je da Kaletra in vivo inducira vlastiti metabolizam i povećava biotransformaciju nekih lijekova koji se metaboliziraju putem enzima citokroma P450 (uključujući CYP2C9 i CYP2C19) i putem glukuronidacije.
English: 4 tablets (400/100 mg) 5 tablets (500/125 mg)
Croatian: 4 tablete (400/100 mg) 5 tableta (500/125 mg)
English: Kaletra is likely to increase plasma concentrations of medicinal products that are primarily metabolised by CYP3A.
Croatian: Kaletra će vjerojatno povisiti plazmatske koncentracije lijekova koji se prvenstveno metaboliziraju putem CYP3A.
English: Benzodiazepines Midazolam
Croatian: Benzodiazepini Midazolam
English: It should be kept in mind that the twice weekly dosage of 150 mg may not provide an optimal exposure to rifabutin thus leading to a risk of rifamycin resistance and a treatment failure.
Croatian: Mora se imati na umu da doza od 150 mg dvaput na tjedan možda neće omogućiti optimalnu izloženost rifabutinu što može voditi do rezistencije na rifampicin i neuspjeha terapije.
English: Besides propylene glycol as described above, Kaletra oral solution contains alcohol (42% v/v) which is potentially harmful for those suffering from liver disease, alcoholism, epilepsy, brain injury or disease as well as for pregnant women and children.
Croatian: Osim propilenglikola, kao što je gore navedeno, Kaletra oralna otopina sadrži i alkohol (42% V/V), koji je potencijalno štetan za osobe s bolestima jetre, alkoholizmom, epilepsijom, ozljedama i bolestima mozga, kao i za trudnice i djecu.
English: • night sweats, itching, rash including raised bumps on the skin, infection of the skin, inflammation of skin or hair pores, accumulation of fluid in the cells or tissues.
Croatian: • noćno znojenje, svrbež, osip uključujući ispupčenja na koži, kožne infekcije, upalu kože ili pora dlačica, nakupljanje tekućine u stanicama ili tkivima.
English: Buproprion and its active metabolite, hydroxybupropion:
Croatian: Buproprion i njegov aktivni metabolit hidroksibupropion:
English: Antibiotic
Croatian: Antibiotici
English: Tenofovir disoproxil fumarate (DF), 300 mg QD
Croatian: Tenofovirdizoproksilfumarat (DF), 300 mg QD
English: Kaletra is not a cure for HIV infection or AIDS.
Croatian: Kaletra nije lijek za infekciju HIV-om ili AIDS.
English: It should not be given when intestinal obstruction is present.
Croatian: Ne treba ga davati ako postoji crijevna opstrukcija.
English: Any inflammatory symptoms should be evaluated and treatment instituted when necessary.
Croatian: Mora se evaluirati svaki simptom upale i po potrebi uvesti terapiju.
English: • abnormal dreams;
Croatian: • neuobičajeni snovi;
English: • midazolam taken orally (taken by mouth), triazolam (used to relieve anxiety and/or trouble sleeping);
Croatian: • midazolam primijenjen peroralno (uzet kroz usta), triazolam (lijek za liječenje tjeskobe i/ili smetnji spavanja);
English: Particular caution must be used when prescribing Kaletra and medicinal products known to induce QT interval prolongation such as: chlorpheniramine, quinidine, erythromycin, clarithromycin.
Croatian: Nužan je osobit oprez kada se propisuju Kaletra i lijekovi za koje se zna da produžuju QT-interval kao što su: klorfeniramin, kinidin, eritromicin, klaritromicin.
English: Contraindicated when used for the treatment of pulmonary arterial hypertension (PAH) only.
Croatian: Kontraindiciran kada se koristi samo za liječenje plućne arterijske hipertenzije (PAH).
English: Lopinavir binds to both alpha-1-acid glycoprotein (AAG) and albumin however, it has a higher affinity for AAG.
Croatian: Lopinavir se veže i na alfa-1-kiseli glikoprotein (AAG) i na albumin, no ima veći afinitet za AAG.
English: Severe hepatic insufficiency.
Croatian: Teška jetrena insuficijencija.
English: The frequency category includes all reported events of moderate to severe intensity, regardless of the individual causality assessment.
Croatian: Kategorija učestalosti uključuje sve zabilježene događaje, po težini umjerene do teške, neovisno o individualnoj procjeni povezanosti.
English: Increased plasma concentrations of alfuzosin which may lead to severe hypotension.
Croatian: Povišena koncentracija alfuzosina u plazmi koja može dovesti do teške hipotenzije.
English: Ranitidine (150 mg single dose)
Croatian: Ranitidin (150 mg jednokratna doza)
English: 300/75 mg/m2 (corresponding to 3.75 ml/m2)
Croatian: 300/75 mg/m2 (što odgovara 3,75 ml/m2)
English: • Haemophilia type A and B as Kaletra might increase the risk of bleeding.
Croatian: • Hemofiliju tip A ili tip B jer Kaletra može povećati rizik od krvarenja.
English: C24: ↑ 20.70-fold
Croatian: C24: ↑ 20,70 puta
English: The following events have been identified as adverse reactions.
Croatian: Niže navedeni događaji su zabilježeni kao nuspojave.
English: Postpartum n = 17**
Croatian: Nakon poroda n = 17**
English: Alpha1 adrenoreceptor antagonist Alfuzosin
Croatian: Alfa1-adrenoreceptor antagonisti Alfuzosin
English: To enhance bioavailability and minimise variability Kaletra is to be taken with food.
Croatian: Kako bi se povećala bioraspoloživost i smanjila biološka varijabilnost, lijek Kaletra treba uzimati s hranom.
English: QTcF interval was evaluated in a randomised, placebo and active (moxifloxacin 400 mg once daily) controlled crossover study in 39 healthy adults, with 10 measurements over 12 hours on Day 3.
Croatian: QTcF interval procijenjen je u randomiziranom, placebom i aktivnim lijekom (moksifloksacin 400 mg jednom dnevno) kontroliranom ukriženom ispitivanju u 39 zdravih osoba, s 10 mjerenja kroz 12 sati tijekom trećeg dana ispitivanja.
English: Parenteral Midazolam:
Croatian: Parenteralni midazolam:
English: Antipsychotics Lurasidone
Croatian: Antipsihotici Lurasidon
English: Lopinavir is an inhibitor of the HIV-1 and HIV-2 proteases.
Croatian: Lopinavir je inhibitor HIV 1 i HIV 2
English: Co-administration is contraindicated.
Croatian: Istodobna primjena je kontraindicirana.
English: As compared to the BID regimen, the once-daily dosing is associated with a reduction in the Cmin/Ctrough values of approximately 50%.
Croatian: U usporedbi s BID režimom, doziranje jednom dnevno je povezano sa smanjenjem Cmin/Ctrough vrijednostima za otprilike 50%.
English: Overdoses with Kaletra oral solution have been reported (including fatal outcome).
Croatian: Zabilježeni su slučajevi predoziranja Kaletra oralnom otopinom (uključujući smrtni ishod).
English: Between week 24 and 48, patients randomised to a dose of 400/100 mg were converted to a dose of 533/133 mg.
Croatian: Između 24. i 48. tjedna bolesnici randomizirani u skupinu koja je primala dozu od 400/100 mg prešli su na dozu od 533/133 mg.
English: In children 14 days of age and older, the nature of the safety profile is similar to that seen in adults (see Table in section b).
Croatian: Kod djece u dobi od 14 dana i starije, sigurnosni profil lijeka sličan je kao i kod odraslih bolesnika (vidjeti tablicu u dijelu b).
English: In children 2 years of age and older, the nature of the safety profile is similar to that seen in adults (see Table in section b).
Croatian: Kod djece stare 2 godine ili više, sigurnosni profil lijeka je sličan kao i kod odraslih bolesnika (vidjeti tablicu u dijelu b).
English: The 230/57.5 mg/m2 dosage might be insufficient in some children when co-administered with nevirapine or efavirenz.
Croatian: Doza od 230/57,5 mg/m2 u neke djece možda neće biti dovoljna kada se primjenjuje istodobno s nevirapinom ili efavirenzom.
English: Monitoring plasma concentrations of methadone is recommended.
Croatian: Preporučuje se praćenje plazmatskih koncentracija metadona.
English: In vitro selection of resistance
Croatian: In vitro izdvojena rezistencija
English: Further dosage reduction of rifabutin to 150 mg twice weekly on set days is recommended for patients in whom the 150 mg dose 3 times per week is not tolerated.
Croatian: Daljnje smanjenje doze rifabutina na 150 mg dvaput tjedno u određene dane se preporučuje kod bolesnika koji ne podnose dozu od 150 mg 3 puta tjedno.
English: Gender, Race and Age
Croatian: Spol, rasa i dob
English: • Symptoms of dizziness, lightheadedness, fainting or sensation of abnormal heartbeats.
Croatian: • Simptome omaglice, ošamućenost, nesvjesticu ili osjećaj nepravilnih otkucaja srca.
English: Sustained virological response to Kaletra (in combination with nucleoside/nucleotide reverse transcriptase inhibitors) has been also observed in a small Phase II study (M97-720) through 360 weeks of treatment.
Croatian: Održani virološki odgovor na lijek Kaletra (u kombinaciji s nukleozidnim/nukleotidnim inhibitorima reverzne transkriptaze) zabilježen je i u malom ispitivanju II. faze (M97-720), u kojem su bolesnici primali terapiju 360 tjedana.
English: The combined effects may lead to increased blood alcohol levels and increase the side effects of alcohol.
Croatian: Objedinjeni učinci mogu dovesti do povišenih razina alkohola u krvi i pojačati nuspojave alkohola.
English: 16/4 mg/kg (corresponding to 0.2 ml/kg)
Croatian: 16/4 mg/kg (što odgovara 0,2 ml/kg)
English: 3rd Trimester n = 23
Croatian: 3. tromjesečje n = 23
English: Erectile dysfunction medicines (avanafil, vardenafil, sildenafil, tadalafil)
Croatian: Lijekovi za liječenje erektilne disfunkcije (avanafil, vardenafil, sildenafil, tadalafil)
English: This medicinal product does not require any special storage conditions.
Croatian: Ovaj lijek ne zahtijeva posebne uvjete čuvanja.
English: 2nd Trimester n = 17*
Croatian: 2. tromjesečje n = 17*
English: * Body surface area can be calculated with the following equation:
Croatian: * Površina tijela (PT) može se izračunati sljedećom formulom:
English: The dose should be administered using a calibrated 2 ml or 5 ml oral dosing syringe best corresponding to the volume prescribed.
Croatian: Lijek treba primjenjivati graduiranom štrcaljkom za peroralnu primjenu volumena 2 ml ili 5 ml koja najbolje odgovara propisanom volumenu.
English: The combination should be used with caution and a lower dose of trazodone should be considered.
Croatian: Ta kombinacija se mora primjenjivati s oprezom i razmotriti primjena manje doze trazodona.
English: In patients currently taking Kaletra and starting lamotrigine: no dose adjustments to the recommended dose escalation of lamotrigine should be necessary.
Croatian: Bolesnici koji trenutno uzimaju lijek Kaletra i započinju uzimanje lamotrigina: Vjerojatno neće biti potrebna prilagodba preporučenog povećanja doze lamotrigina.
English: Other medicines and Kaletra
Croatian: Drugi lijekovi i Kaletra
English: These effects have been assumed to be caused by electrolyte disturbance.
Croatian: Drži se da su ti učinci bili prouzročeni poremećenom ravnotežom elektrolita.
English: (combinations of mechanisms including CYP3A inhibition)
Croatian: (kombinacije mehanizama, uključujući inhibiciju CYP3A)
English: If the benefit is considered to outweigh the risk and Kaletra must be used, reduce the ibrutinib dose to 140 mg and monitor patient closely for toxicity.
Croatian: Ukoliko se smatra da korist nadmašuje rizik i lijek Kaletra se mora koristiti, dozu ibrutiniba treba smanjiti na 140 mg i pomno pratiti bolesnika radi toksičnosti.
English: Ritonavir has been shown to induce metabolic enzymes, resulting in the induction of its own metabolism, and likely the induction of lopinavir metabolism.
Croatian: Pokazalo se da ritonavir inducira metaboličke enzime, čime inducira i svoj vlastiti metabolizam, a vjerojatno i metabolizam lopinavira.
English: Very common: may affect more than 1 in 10 people
Croatian: Vrlo česte: mogu se javiti u više od 1 na 10 osoba
English: Lifepharma (Z.A.M.)
Croatian: Lifepharma (Z.A.M.) Ltd
English: No subject experienced an increase in QTcF of ≥ 60 ms from baseline or a QTcF interval exceeding the potentially clinically relevant threshold of 500 ms.
Croatian: Niti jedna osoba koja je sudjelovala u studiji nije imala povećanje QTcF za ≥ 60 ms u odnosu na početnu vrijednost ili QTcF interval koji je prešao potencijalno klinički značajan prag od 500 ms.
English: However, dialysis can remove both alcohol and propylene glycol in the case of overdose with Kaletra oral solution.
Croatian: Međutim, dijalizom se mogu ukloniti alkohol i propilenglikol u slučaju predoziranja Kaletra oralnom otopinom.
English: Resistance to nelfinavir, defined as the presence of the D30N or L90M mutation in protease, was observed in 41/96 (43%) patients.
Croatian: Rezistencija na nelfinavir, definirana kao prisustvo D30N ili L90M mutacije u proteazi je zabilježena kod 41/96 (43%) bolesnika.
English: Fluvastatin is partially metabolised by CYP2C9.
Croatian: Fluvastatin se djelomice metabolizira putem CYP2C9.
English: At the recommended adult dose(s) of this medicine, the estimated blood alcohol concentration in your body is about 0.002 - 0.01 g/dL.
Croatian: Procijenjena koncentracija alkohola u krvi kod primjene preporučene(ih) doze(a) za odrasle iznosi približno 0,002 - 0,01 g/dl.
English: Initially, bosentan Cmin: ↑ by approximately 48-fold.
Croatian: Početno, bosentan Cmin: ↑ za otprilike 48 puta
English: • fusidic acid (used to treat skin infections caused by Staphylococcus bacteria such as impetigo and infected dermatitis).
Croatian: • fusidatnu kiselinu (za liječenje kožnih infekcija uzrokovanih bakterijom roda Staphylococcus kao što su impetigo i infektivni dermatitis.
English: Given the pharmacokinetic interaction between Kaletra and tenofovir (see section 4.5), the results of this study might not be strictly extrapolable when other backbone regimens are used with Kaletra.
Croatian: Obzirom na farmakokinetičku interakciju lijeka Kaletra i tenofovira (vidjeti dio 4.5), rezultati ove studije možda nisu doslovno primjenjivi kada se u kombinaciji s lijekom Kaletra primjenjuju drugi osnovni režim.
English: Anticoagulants Warfarin
Croatian: Antikoagulansi Varfarin
English: In dogs, prominent U waves on the electrocardiogram have been observed associated with prolonged PR interval and bradycardia.
Croatian: U pasa su uočeni izraženi U-valovi na elektrokardiogramu, povezani s produženim PR-intervalom, te bradikardijom.
English: An increase in weight and in levels of blood lipids and glucose may occur during antiretroviral therapy.
Croatian: Povećanje tjelesne težine i razina lipida i glukoze u krvi mogu se pojaviti tijekom antiretrovirusne terapije.
English: This medicinal product contains up to 0.8 g of fructose per dose when taken according to the dosage recommendations.
Croatian: Ovaj lijek sadrži do 0,8 g fruktoze po dozi, ako se uzima u preporučenim dozama.
English: In general, rebound isolates either retained (if cross-resistant at baseline) or developed significant cross-resistance to indinavir, saquinavir and atazanavir.
Croatian: Izolirani sojevi kod ponovnog porasta broja virusa su, uglavnom, zadržali (ako su bili križno rezistentni na početku) ili razvili značajnu križnu rezistenciju na indinavir, sakvinavir i atazanavir.
English: Use in children of 2 years of age and above
Croatian: Djeca u dobi od 2 godine i starija
English: • Do not use Kaletra after the expiry date which is stated on the bottle.
Croatian: • Kaletra se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na boci.
English: • breakdown of muscle fibres resulting in the release of muscle fibre contents (myoglobin) into the bloodstream;
Croatian: • pucanje mišićnih vlakana što rezultira oslobađanjem sadržaja mišićnih vlakana (mioglobina) u krvotok;
English: ≥ 15 to 40 kg
Croatian: ≥ 15 do 40 kg
English: Can cause headache and stomach upset and diarrhoea.
Croatian: Može uzrokovati glavobolju, želučane smetnje i proljev.
English: Patients had not been on prior lopinavir/ritonavir therapy.
Croatian: Bolesnici nisu bili na ranijoj terapiji lopinavirom/ritonavirom.
English: • quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder);
Croatian: • kvetiapin (lijek za liječenje shizofrenije, bipolarnog poremećaja i velikog depresivnog poremećaja);
English: Place the tip of the syringe into the liquid.
Croatian: Uronite vrh štrcaljke u tekućinu.
English: No studies on the effects on the ability to drive and use machines have been performed.
Croatian: Nisu provedene studije utjecaja na sposobnost upravljanja vozilima i rada sa strojevima.
English: • antidepressants (e.g. trazodone, bupropion);
Croatian: • antidepresivi (npr. trazodon, bupropion);
English: dosage adjustment recommendations.
Croatian: preporuke vezane uz prilagodbu doze.
English: ** n = 16 for Cpredose
Croatian: ** n = 16 for Cprije početka liječenja
English: • It is important that all doses of Kaletra oral solution are taken with food.
Croatian: • Važno je da se Kaletra oralna otopina uvijek uzima zajedno s hranom.
English: Pregnant or breast-feeding mothers should not take Kaletra oral solution unless specifically directed by the doctor.
Croatian: Trudnice i dojilje ne smiju uzimati Kaletra oralnu otopinu, osim ako im to izričito ne kaže liječnik.
English: • lurasidone (used to treat depression);
Croatian: • lurasidon (lijek za liječenje depresije);
English: • In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Croatian: • Kod nekih bolesnika s uznapredovalom HIV infekcijom i oportunističkom infekcijom u povijesti bolesti, znakovi i simptomi od prethodno preboljelih infekcija se mogu pojaviti ubrzo nakon početka anti-HIV liječenja.
English: Mutations L33F, I50V and V32I combined with I47V/A were also observed.
Croatian: L33F, I50V i V32I u kombinaciji s mutacijom I47V/A.
English: Plasma concentrations of lopinavir were measured over four 12-hour periods during second trimester (20-24 weeks gestation), third trimester before dose increase (30 weeks gestation), third trimester after dose increase (32 weeks gestation), and at 8 weeks post-partum.
Croatian: Plazmatske koncentracije lopinavira mjerene su tijekom četiri 12-satna razdoblja u drugom tromjesečju (20-24 tjedana trudnoće), trećem tromjesečju prije povećanja doze (30 tjedana trudnoće), trećem tromjesečju nakon povećanja doze (32 tjedna trudnoće) i 8 tjedana nakon poroda.
English: The pharmacokinetic properties of lopinavir co-administered with ritonavir have been evaluated in healthy adult volunteers and in HIV-infected patients; no substantial differences were observed between the two groups.
Croatian: Farmakokinetička svojstva lopinavira, primijenjenog u kombinaciji s ritonavirom, ocijenjena su u zdravih odraslih dragovoljaca i bolesnika zaraženih HIV-om; između dviju skupina nije uočena znatnija razlika.
English: • alfuzosin (used in men to treat symptoms of an enlarged prostate (benign prostatic hyperplasia (BPH));
Croatian: • alfuzosin (lijek za liječenje simptoma povećane prostate kod muškaraca (benigna hiperplazija prostate, BHP));
English: No human data on the effect of lopinavir/ritonavir on fertility are available.
Croatian: Ne postoje podaci o učinku lopinavira/ritonavira na plodnost kod ljudi.
English: Headache (including migraine), neuropathy (including peripheral neuropathy), dizziness, insomnia
Croatian: Glavobolja (uključujući migrenu), neuropatija (uključujući perifernu neuropatiju), omaglica,
English: Age: ≥ 6 weeks and < 6 months (N=21)
Croatian: Dob: ≥ 6 tjedana i < 6 mjeseci (N=21)
English: Pancreatitis1, vomiting, gastrooesophageal reflux disease, gastroenteritis and colitis, abdominal pain (upper and lower), abdominal distension, dyspepsia, haemorrhoids, flatulence
Croatian: Pankreatitis1, povraćanje, gastroezofagealna refluksna bolest, gastroenteritis i kolitis, bol u abdomenu (gornji i donji dio), distenzija abdomena, dispepsija, hemoroidi, flatulencija
English: • increased cholesterol levels in your blood, increased triglycerides (a form of fat) levels in your blood, high blood pressure;
Croatian: • povećanje razine kolesterola u krvi, povećane razine triglicerida (oblik masnoće) u krvi, visoki krvni tlak;
English: Appropriate laboratory testing should be conducted prior to initiating therapy with lopinavir/ritonavir and close monitoring should be performed during treatment.
Croatian: Odgovarajuće laboratorijsko testiranje treba biti provedeno prije započinjanja liječenja lopinavirom/ritonavirom te je tijekom liječenja potrebno pomno praćenje.
English: Around 85% of patients had a viral load of < 100,000 copies/ml.
Croatian: Oko 85% bolesnika je imalo količinu virusa manju od 100.000 kopija/ml.
English: Adequate exposure to lopinavir/ritonavir may be achieved when a higher dose of Kaletra is used but this is associated with a higher risk of liver and gastrointestinal toxicity.
Croatian: Zadovoljavajuća izloženost lopinaviru/ritonaviru može se postići uzimanjem većih doza lijeka Kaletra, no to je povezano s povećanim rizikom od jetrene i gastrointestinalne toksičnosti.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and can occur many months after initiation of treatment (see section 4.4).
Croatian: Zabilježena je pojava autoimunih poremećaja (kao što su Gravesova bolest i autoimuni hepatitis), međutim, zabilježeno vrijeme do njihove pojave je vrlo varijabilno, a mogu se pojaviti i mnogo mjeseci nakon početka liječenja (vidjeti dio 4.4).
English: Only at high inadvertent doses, it can cause headache and gastrointestinal upset.
Croatian: Samo pri velikim, nehotice uzetim dozama može prouzročiti glavobolju i gastrointestinalne smetnje.
English: While rosuvastatin is poorly metabolised by CYP3A4, an increase of its plasma concentrations was observed.
Croatian: Iako se rosuvastatin slabo metabolizira putem CYP3A4, uočeno je povećanje njegovih koncentracija u plazmi.
English: Kaletra oral solution contains up to 0.3 g of glycerol per dose.
Croatian: Kaletra oralna otopina sadrži do 0,3 g glicerola po dozi.
English: Post-marketing cases have been reported indicating a potential interaction between ritonavir containing products and levothyroxine.
Croatian: Nakon stavljanja lijeka u promet zabilježeni su slučajevi koji ukazuju na moguću interakciju lijekova koji sadrže ritonavir i levotiroksina.
English: • muscle disorders such as weakness and spasms, pain in the joints, muscles and back;
Croatian: • poremećaj mišića kao što su slabosti i grčevi, bol u zglobovima, mišićima i leđima;
English: Carcinogenicity studies in rats revealed no tumourigenic findings.
Croatian: U ispitivanjima kancerogenosti u štakora nisu nađeni dokazi o tumorogenosti.
English: Valproate: ↓
Croatian: Valproat: ↓
English: Tell your doctor or pharmacist if you or your child are taking, have recently taken or might take any other medicines, including medicines obtained without prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako Vi ili Vaše dijete uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući i one koji se mogu nabaviti bez recepta.
English: • abnormally high level of bilirubin (a pigment produced from the breakdown of red blood cells)
Croatian: • neuobičajeno visoka razina bilirubina (pigmenta koji nastaje raspadanjem crvenih krvnih stanica) u krvi
English: Important information about some of the ingredients of Kaletra
Croatian: Važne informacije o nekim pomoćnim sastojcima u lijeku Kaletra
English: Thereby, increasing the potential for sildenafil-associated adverse events (which include hypotension and syncope).
Croatian: Time je povećana mogućnost pojave štetnih događaja povezanih sa sildenafilom (koje uključuju hipotenziju i sinkopu).
English: The Kaletra dose should be titrated upward only after rifampicin has been initiated (see section 4.4).
Croatian: Doza lijeka Kaletra smije se povećavati tek nakon uvođenja rifampicina (vidjeti dio 4.4).