FrancophonIA/ELRC3.0 huggingface dataset:
English: After subcutaneous injection of Semglee in diabetic patients, insulin glargine is rapidly metabolized at the carboxyl terminus of the Beta chain with formation of two active metabolites M1 (21A-Gly-insulin) and M2 (21A-Gly-des-30B-Thr-insulin).
Croatian: Nakon supkutane primjene lijeka Semglee u bolesnika sa šećernom bolešću inzulin glargin brzo se metabolizira na karboksilnim krajevima beta lanca, pri čemu nastaju dva aktivna metabolita, M1 (21A-Gly-inzulin) i M2 (21A-Gly-des-30B-Thr-inzulin).
English: Physiological concentrations of endogenous IGF-1 may activate the mitogenic-proliferative pathway; however, the therapeutic concentrations found in insulin therapy, including in Semglee therapy, are considerably lower than the pharmacological concentrations required to activate the IGF-1 pathway.
Croatian: Fiziološke koncentracije endogenog IGF-1 proteina mogu aktivirati mitogeno-proliferativni put; međutim, terapijske koncentracije koje se postižu u liječenju inzulinom, uključujući i liječenje lijekom Semglee, znatno su niže od farmakoloških koncentracija potrebnih za aktivaciju IGF-1 metaboličkog puta.
English: Remove the needle after the injection and store the pen without the needle.
Croatian: Nakon injekcije uklonite iglu i pohranite brizgalicu bez pričvršćene igle.
English: Such reactions to insulin (including insulin glargine) or the excipients may, for example, be associated with generalised skin reactions, angio-oedema, bronchospasm, hypotension and shock, and may be life-threatening.
Croatian: Takve reakcije na inzulin (uključujući inzulin glargin) ili na pomoćne tvari mogu, primjerice, biti povezane s generaliziranim kožnim reakcijama, angioedemom, bronhospazmom, hipotenzijom i šokom te mogu ugroziti život.
English: What Semglee contains
Croatian: Što Semglee sadrži
English: • There are no cracks, breaks or leaks around the cartridge holder
Croatian: • nema pukotina, lomova ni istjecanja oko držača uloška.
English: • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
Croatian: • može se zatvoriti čvrstim poklopcem koji se ne može probiti i kroz koji ne mogu izaći oštri predmeti,
English: Although Semglee contains the same active substance as insulin glargine 300 units/ml, these medicines are not interchangeable.
Croatian: Iako Semglee sadrži istu djelatnu tvar kao inzulin glargin 300 jedinica/ml, ovi lijekovi nisu međusobno zamjenjivi.
English: Packs of 1, 3, 5, 10 and multipack containing 10 (2 packs of 5) pens.
Croatian: Pakiranja sadrže 1, 3, 5, 10 i višestruka pakiranja koja sadrže 10 (2 pakiranja sa po 5) brizgalica.
English: Keep your pen and needles out of sight and reach of children.
Croatian: Brizgalicu i igle držite izvan pogleda i dohvata djece.
English: • You can clean the outside of your pen by wiping it with a damp cloth.
Croatian: • Vanjski dio svoje brizgalice možete prebrisati vlažnom krpom.
English: • Check that the medicine in the pen cartridge looks clear and colourless.
Croatian: • Provjerite je li lijek u ulošku brizgalice bistar i bezbojan.
English: IGF-1 receptor binding: The affinity of insulin glargine for the human IGF-1 receptor is approximately 5 to 8-fold greater than that of human insulin (but approximately 70 to 80-fold lower than the one of IGF-1), whereas M1 and M2 bind the IGF-1 receptor with slightly lower affinity compared to human insulin.
Croatian: Vezanje za IGF-1 receptor: Afinitet vezanja inzulina glargina za ljudski IGF-1 receptor otprilike je 5 do 8 puta veći nego afinitet ljudskog inzulina (ali približno 70 do 80 puta manji nego afinitet IGF-1 receptora), dok je afinitet vezanja metabolita M1 i M2 za IGF-1 receptor nešto manji nego afinitet ljudskog inzulina.
English: Over the course of this 6-year study, 42% of the insulin glargine group did not experience any hypoglycaemia.
Croatian: Tijekom ovog 6-godišnjeg ispitivanja, u 42 % ispitanika u skupini koja je primala inzulin glargin nije zabilježen niti jedan događaj hipoglikemije.
English: Empty pens must never be reused and must be properly discarded.
Croatian: Prazne brizgalice nikada se ne smiju ponovno koristiti i moraju se ukloniti u skladu s propisima.
English: Semglee is not the insulin of choice for the treatment of diabetic ketoacidosis.
Croatian: Semglee nije odgovarajući inzulin za liječenje dijabetičke ketoacidoze.
English: A - Inspect the pen: check the purple and white label on the pen to make sure:
Croatian: - Pregledajte brizgalicu: provjerite ljubičastu i bijelu naljepnicu na brizgalici kako biste utvrdili sljedeće:
English: A - Check that the dose window shows “0”.
Croatian: - Provjerite je li u prozorčiću za prikaz doze prikazana oznaka „0”.
English: The prolonged duration of action of Semglee is dependent on its injection into subcutaneous tissue.
Croatian: Produljeno djelovanje lijeka Semglee ovisi o injiciranju u supkutano tkivo.
English: With the other hand pull off the pen cap.
Croatian: Drugom rukom skinite zatvarač brizgalice.
English: • Sterile disposable hypodermic needle compatible with this pen
Croatian: • sterilna jednokratna hipodermijska igla prikladna za uporabu s brizgalicom
English: At baseline, participants had a median HbA1c value of 6.4% and median on-treatment HbA1c values ranged from 5.9 to 6.4% in the insulin glargine group, and 6.2% to 6.6% in the standard care group throughout the duration of follow-up.
Croatian: Sudionici su na početku ispitivanja imali medijan vrijednosti HbA1c od 6,4 %, dok se medijan vrijednosti HbA1c tijekom liječenja kretao u rasponu od 5,9 do 6,4 % u skupini koja je primala inzulin glargin te od 6,2 do 6,6 % u skupini koja je primala standardno liječenje tijekom čitavoga razdoblja praćenja.
English: If you inject your insulin too often at the same skin site, fatty tissue under the skin at this site may either shrink (lipoatrophy, may affect up to 1 in 100 people) or thicken (lipohypertrophy).
Croatian: Pri učestalom injiciranju inzulina na isto mjesto na koži, supkutano masno tkivo na tom mjestu može se smanjiti (lipoatrofija, može se javiti u manje od 1 na 100 osoba) ili zadebljati (lipohipertrofija).
English: D - Tap the cartridge gently with your finger to help any large air bubbles to move to the top of the cartridge.
Croatian: D - Prstom lagano lupnite po ulošku kako bi se veliki mjehurići zraka pomaknuli prema vrhu uloška.
English: Mild episodes of hypoglycaemia can usually be treated with oral carbohydrates.
Croatian: Blage epizode hipoglikemije obično se mogu liječiti oralnim uzimanjem ugljikohidrata.
English: B - While holding the pen body facing upwards, attach the outer needle cap straight on to the cartridge holder as shown.
Croatian: B - Dok tijelo brizgalice držite usmjereno prema gore, pričvrstite vanjski zatvarač igle izravno na držač uloška kako je prikazano.
English: Pharmacotherapeutic group: Drugs used in diabetes, insulins and analogues for injection, long-acting.
Croatian: Farmakoterapijska skupina: pripravci za liječenje šećerne bolesti; inzulini i analozi za injiciranje dugog djelovanja.
English: If you notice signs of your blood sugar being too low (hypoglycaemia), take action to increase your blood sugar level straight away (see the box at the end of this leaflet).
Croatian: Ako primijetite znakove preniske razine šećera u krvi (hipoglikemija), odmah poduzmite mjere za povećanje razine šećera u krvi (pogledajte okvir na kraju ove upute).
English: There were no differences between insulin glargine and standard care for the two co-primary outcomes; for any component endpoint comprising these outcomes; for all-cause mortality; or for the composite microvascular outcome.
Croatian: Nisu primijećene razlike između inzulina glargina i standardnog liječenja za dva primarna ishoda, za bilo koju mjeru koja je sastavnica navedenih ishoda, za smrtnost zbog bilo kojeg uzroka niti za kompozitni mikrovaskularni ishod.
English: Participants were randomised (1:1) to receive insulin glargine (n=6264), titrated to reach FPG ≤95 mg/dl (5.3 mM), or standard care (n=6273).
Croatian: Sudionici su randomizirani (1:1) da primaju inzulin glargin (n = 6264), titriran kako bi se postigla razina glukoze u plazmi natašte od ≤ 95 mg/dl (5,3 mmol/l), ili standardno liječenje (n = 6273).
English: B - Turn the white dose knob until the yellow dose pointer lines up with your required dose.
Croatian: B - Okrećite bijeli kotačić za doziranje sve dok se žuti pokazivač doze ne poravna s potrebnom dozom.
English: Semglee in pre-filled pen is only suitable for injecting just under the skin (see also section 3).
Croatian: Semglee u napunjenoj brizgalici prikladan je isključivo za ubrizgavanje neposredno pod kožu (vidjeti dio 3).
English: Hydrochloric acid (for pH adjustment)
Croatian: Kloridna kiselina (za prilagodbu pH)
English: C - Check the insulin through the cartridge holder to make sure:
Croatian: C - Kroz držač uloška provjerite inzulin kako biste utvrdili sljedeće:
English: Do not use alcohol, hydrogen peroxide, bleach, or any other liquids to clean your pen.
Croatian: Za čišćenje brizgalice nemojte upotrebljavati alkohol, vodikov peroksid, izbjeljivač niti bilo koju drugu tekućinu.
English: After first use of the pen, store it at room temperature up to 30°C.
Croatian: Nakon prve uporabe brizgalicu čuvajte na sobnoj temperaturi do 30°C.
English: One hundred forty three of the patients treated with insulin glargine in this study continued treatment with insulin glargine in an uncontrolled extension study with mean duration of follow-up of 2 years.
Croatian: Ukupno 143 bolesnika liječena inzulinom glarginom u ovom ispitivanju nastavila su liječenje inzulinom glarginom u nekontroliranom produžetku ispitivanja sa srednjom vrijednosti trajanja praćenja od 2 godine.
English: E - Carefully pull off the inner needle cap and throw it away.
Croatian: D - Pažljivo skinite unutarnji zatvarač igle i bacite ga.
English: Combination of Semglee with pioglitazone
Croatian: Kombinacija lijeka Semglee i pioglitazona
English: Before first using the pen, store the cartons containing the pen in the refrigerator (2°C to 8°C).
Croatian: Prije prve uporabe brizgalice pakiranja s brizgalicama čuvajte u hladnjaku (2°C - 8°C).
English: To reduce the risk of hypoglycemia, patients who are changing their basal insulin regimen from an insulin regimen with once daily insulin glargine 300 units/ml to a once daily regimen with Semglee should reduce their dose by approximately 20%.
Croatian: Kako bi se smanjio rizik od hipoglikemije, bolesnici koji mijenjaju svoj režim uzimanja bazalnog inzulina s uzimanja inzulina glargina 300 jedinica/ml jednom dnevno na režim uzimanja lijeka Semglee jednom dnevno, trebaju smanjiti svoju dozu za približno 20 %.
English: If you do not have a sharps container, you may use a household container that is:
Croatian: Ako nemate spremnik za zbrinjavanje oštrih predmeta, možete upotrijebiti spremnik sa sljedećim obilježjima:
English: Pre-filled pens in use or carried as a spare may be stored for a maximum of 4 weeks not above 30°C and away from direct heat or direct light.
Croatian: Napunjene brizgalice u uporabi ili rezervne brizgalice mogu se čuvati najdulje 4 tjedna na temperaturi do 30°C, zaštićene od izvora topline i izravne svjetlosti.
English: Correspondingly, the incidences of nocturnal hypoglycaemia were 32% in the insulin glargine / lispro group versus 52% in the NPH / regular group.
Croatian: U skladu s time, incidencija noćne hipoglikemije iznosila je 32 % u skupini koja je primala inzulin glargin/lispro u odnosu na 52 % u skupini koja je primala NPH/obični inzulin.
English: Do not use the pen if the medicine in the cartridge looks cloudy, coloured or if you can see particles.
Croatian: Brizgalicu nemojte upotrebljavati ako je lijek u ulošku zamućen, obojen ili ako su vidljive čestice.
English: Semglee is available in pack sizes of 1, 3, 5, 10 pens and in a multipack compromising of 2 cartons, each containing 5 pens.
Croatian: Semglee je dostupan u pakiranju od 1, 3, 5, 10 brizgalica i u višestrukom pakiranju koje se sastoji od 2 kutije, od kojh svaka sadrži 5 brizgalica.
English: • Use an injection site that your healthcare provider has shown you.
Croatian: • Lijek injicirajte na mjesto koje vam je pokazao Vaš liječnik.
English: The ORIGIN (Outcome Reduction with Initial Glargine INtervention) study was a multicenter, randomised, 2x2 factorial design study conducted in 12,537 participants at high cardiovascular (CV) risk with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) (12% of participants) or type 2 diabetes mellitus treated with ≤1 antidiabetic oral agent (88% of participants).
Croatian: Outcome Reduction with Initial Glargine INtervention) bilo je multicentrično, randomizirano ispitivanje faktorijalnog dizajna 2×2, provedeno na 12 537 sudionika s visokim kardiovaskularnim rizikom i poremećajem razine glukoze natašte ili narušenom tolerancijom glukoze (12 % sudionika) ili šećernom bolešću tipa 2 liječenom ≤ 1 oralnim antidijabetikom (88 % ispitanika).
English: If you stop using Semglee
Croatian: Ako prestanete primjenjivati Semglee
English: As you turn the white dose knob to set your dose, it will extend out and you will hear a “click” at each unit dialled.
Croatian: Dok okrećete bijeli kotačić za doziranje kako biste postavili dozu, kotačić će se produljiti i svakim odabirom jedinice začut ćete „klik”.
English: • Skin and allergic reactions at the injection site The signs may include reddening, unusually intense pain when injecting, itching, hives, swelling or inflammation.
Croatian: • Kožne i alergijske reakcije na mjestu injiciranja Znakovi mogu uključivati crvenilo, neuobičajeno jaku bol prilikom injiciranja, svrbež, osip, oticanje ili upalu.
English: Do not leave the needle attached to the pen during storage or reuse needles.
Croatian: Prilikom pohrane nemojte ostavljati iglu pričvršćenu na brizgalicu ili ponovno upotrebljavati igle.
English: Switch from other insulins to Semglee
Croatian: Prijelaz s drugih inzulina na Semglee
English: Semglee should not be administered intravenously.
Croatian: Semglee se ne smije primjenjivati intravenski.
English: Switch from insulin glargine 300 units/ml to Semglee Semglee and insulin glargine 300 units/ml are not bioequivalent and are not directly interchangeable.
Croatian: Prijelaz s inzulina glargina jačine 300 jedinica/ml na Semglee Semglee i inzulin glargin 300 jedinica/ml nisu bioekvivalentni i nisu izravno međusobno zamjenjivi.
English: D - Replace the pen cap over the cartridge.
Croatian: D - Zamijenite zatvarač brizgalice preko uloška.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON (with blue box) multipack - 10 (2x5 pens)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU UNUTARNJA KUTIJA (sa plavim okvirom) višestruko pakiranje - 10 (2x5 brizgalica)
English: Glycohaemoglobin and glucose variabilities were comparable in both treatment groups.
Croatian: Varijabilnosti u vrijednostima glikiranog hemoglobina i glukoze bile su usporedive u objema terapijskim skupinama.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA Not applicable
Croatian: JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM Nije primjenivo.
English: Read carefully the "Instructions for Use" included in this package leaflet.
Croatian: Pažljivo pročitajte „Upute za uporabu” koje su sastavni dio ove upute o lijeku.
English: After injection into the subcutaneous tissue, the acidic solution is neutralised leading to formation of micro-precipitates from which small amounts of insulin glargine are continuously released, providing a smooth, peakless, predictable concentration/time profile with a prolonged duration of action.
Croatian: Nakon injekcije u supkutano tkivo, kisela otopina neutralizira se i stvaraju se mikroprecipitati iz kojih se neprestano otpuštaju male količine inzulina glargina, što osigurava ravnomjernu, predvidljivu koncentraciju lijeka kroz vrijeme, bez vršnih koncentracija i s produljenim djelovanjem.
English: Due to more sustained basal insulin supply with Semglee, less nocturnal but more early morning hypoglycaemia can be expected.
Croatian: Zbog ravnomjernije opskrbe bazalnim inzulinom kod primjene lijeka Semglee, može se očekivati manje noćnih te više ranojutarnjih epizoda hipoglikemije.
English: Examples of symptoms that indicate a low sugar level in the brain: headaches, intense hunger, nausea, vomiting, tiredness, sleepiness, sleep disturbances, restlessness, aggressive behaviour, lapses in concentration, impaired reactions, depression, confusion, speech disturbances (sometimes total loss of speech), visual disorders, trembling, paralysis, tingling sensations (paraesthesia), numbness and tingling sensations in the area of the mouth, dizziness, loss of self-control, inability to look after yourself, convulsions, loss of consciousness.
Croatian: Sljedeći simptomi ukazuju na nisku razinu šećera u mozgu: glavobolje, jaka glad, mučnina, povraćanje, umor, pospanost, poremećaji spavanja, nemir, agresivno ponašanje, poteškoće s koncentracijom, slabije reakcije, depresija, smetenost, poremećaji govora (ponekad potpun gubitak sposobnosti govora), poremećaji vida, drhtavica, paraliza, trnci (parestezije), utrnulost i trnci u području usta, omaglica, gubitak samokontrole, nesposobnost vođenja brige o samome sebi, konvulzije, gubitak svijesti.
English: Do not share your Semglee pre-filled pen with other people, even if the needle has been changed.
Croatian: Napunjenu brizgalicu Semglee nemojte dijeliti s drugim osobama, čak ni ako ste zamijenili iglu.
English: Semglee can be used in adolescents and children aged 2 years and above.
Croatian: Semglee se može koristiti u adolescenata i djece u dobi od 2 ili više godina.
English: If you forget to use Semglee
Croatian: Ako ste zaboravili primijeniti Semglee
English: Type I colourless glass cartridge with a plunger (bromobutyl rubber), sealed using lined seals (laminate of polyisoprene and bromobutyl rubber).
Croatian: Uložak od bezbojnog stakla tipa 1 s klipom (bromobutilna guma), zatvoren obloženim zaštitnim čepovima (poliizoprenski laminat i bromobutilna guma).
English: Effects of insulin glargine (once daily) on diabetic retinopathy were evaluated in an open-label 5-year NPH-controlled study (NPH given bid) in 1024 type 2 diabetic patients in which progression of retinopathy by 3 or more steps on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale was investigated by fundus photography.
Croatian: Učinak inzulina glargina (primijenjenog jedanput dnevno) na dijabetičku retinopatiju ocijenjen je u 5-godišnjem otvorenom kliničkom ispitivanju kontroliranom NPH inzulinom (NPH primijenjen dvaput na dan) na 1024 bolesnika sa šećernom bolešću tipa 2, u kojih je progresija retinopatije za više od 3 stupnja na ljestvici ETDRS (Early Treatment Diabetic Retinopathy Study) bila ispitana fotografiranjem fundusa.
English: Do not freeze or place next to the freezer compartment or a freezer pack.
Croatian: Ne zamrzavati ili staviti neposredno uz zamrzivač ili rashladni uložak.
English: - The other ingredients are: zinc chloride, metacresol, glycerol, sodium hydroxide (for pH adjustment) (see section 2 “Semglee contains sodium”), hydrochloric acid (for pH adjustment) and water for injections.
Croatian: - Drugi sastojci su: cinkov klorid, metakrezol, glicerol, natrijev hidroksid (za prilagodbu pH) (vidjeti dio 2 „Semglee sadrži natrij”), kloridna kiselina (za prilagodbu pH) i voda za injekcije.
English: Do not freeze the pen.
Croatian: Nemojte zamrzavati brizgalicu.
English: Inject your dose A - If instructed by your healthcare provider you can pinch the cleaned skin between your fingers.
Croatian: Injiciranje doze A - U skladu s uputama liječnika, prstima uhvatite očišćenu kožu.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING IMMEDIATE CARTON (without blue box) component of multipack - 5 pens
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKA KUTIJA (bez plavog okvira) višestruko pakiranje - 5 brizgalica
English: B - Squeeze the wide part of the outer needle cap and unscrew the needle in an anti-clockwise (left) direction.
Croatian: B - Stisnite širi dio vanjskog zatvarača igle i odvrnite iglu u smjeru suprotnom od smjera kazaljke sata (ulijevo).
English: Make sure you have the following items before injecting your dose:
Croatian: Prije injiciranja doze provjerite imate li sljedeće stavke:
English: Step 8.
Croatian: 8. korak.
English: Examples of symptoms that tell you that your blood sugar level is falling too much or too fast: sweating, clammy skin, anxiety, fast heart beat, high blood pressure, palpitations and irregular heartbeat.
Croatian: Sljedeći Vam simptomi govore da razina šećera u krvi previše ili prebrzo pada: znojenje, ljepljiva koža, tjeskoba, ubrzani otkucaji srca, visok krvni tlak, osjećaj lupanja srca ili nepravilan srčani ritam.
English: Semglee is used to treat diabetes mellitus in adults, adolescents and children aged 2 years and above.
Croatian: Semglee se koristi za liječenje šećerne bolesti u odraslih, adolescenata i djece u dobi od 2 i više godina.
English: Only use needles that are compatible for use with this pre-filled pen.
Croatian: Smiju se upotrebljavati samo igle koje su prikladne za uporabu s napunjenom brizgalicom.
English: • Inject the amount left in your pen and use a new pen to give the rest of your dose, or
Croatian: • injicirati količinu preostalu u brizgalici i za injiciranje preostale doze upotrijebiti novu brizgalicu ili • upotrijebiti novu brizgalicu i injicirati potpunu dozu.
English: Do not use Semglee - if you are allergic to insulin glargine or any of the other ingredients of this medicine (listed in section 6).
Croatian: Što morate znati prije nego počnete primjenjivati Semglee Nemojte primjenjivati Semglee: - ako ste alergični na inzulin glargin ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: The first symptoms which alert you to hypoglycaemia ("warning symptoms") may change, be weaker or may be missing altogether if - you are elderly, if you have had diabetes for a long time or if you suffer from a certain type of nervous disease (diabetic autonomic neuropathy), - you have recently suffered hypoglycaemia (for example the day before) or if it develops slowly, - you have almost normal or, at least, greatly improved blood sugar levels, - you have recently changed from an animal insulin to a human insulin such as Semglee, - you are taking or have taken certain other medicines (see section 2, "Other medicines and
Croatian: Prvi simptomi koji Vas mogu upozoriti na hipoglikemiju („upozoravajući simptomi”) mogu se promijeniti, biti manje izraženi ili potpuno izostati: - ako ste starije dobi, ako dugo imate šećernu bolest ili bolujete od određene vrste neurološke bolesti (dijabetička autonomna neuropatija), - ako ste nedavno imali hipoglikemiju (primjerice dan ranije) ili ako se hipoglikemija sporo razvija, - ako imate gotovo normalnu razinu šećera ili ako Vam se razina šećera u krvi znatno poboljšala, - ako ste nedavno prešli s inzulina životinjskog podrijetla na ljudski inzulin kao što je Semglee, - ako uzimate ili ste uzimali neke druge lijekove (vidjeti dio 2. „Drugi lijekovi i Semglee”).
English: The adverse reaction reports received from post marketing surveillance included relatively more frequent injection site reactions (injection site pain, injection site reaction) and skin reactions (rash, urticaria) in children and adolescents (≤ 18 years of age) than in adults.
Croatian: Prijave nuspojava nakon stavljanja lijeka u promet relativno češće uključuju reakcije na mjestu injiciranja (bol na mjestu injiciranja, reakcija na mjestu injiciranja) i kožne reakcije (osip, urtikarija) u djece i adolescenata (≤ 18 godina) nego u odraslih.
English: *Insulin glargine is produced by recombinant DNA technology in Pichia pastoris.
Croatian: * Inzulin glargin proizveden je tehnologijom rekombinantne DNK na metilotrofnom kvascu
English: Trying to attach the outer needle cap sideways may bend or damage the needle.
Croatian: Ako vanjski zatvarač igle pokušate pričvrstiti sa strane, možete saviti ili oštetiti iglu.
English: • Avoid dropping your pen as this can cause the cartridge to break, or can damage the pen.
Croatian: • Pripazite da vam brizgalica ne ispadne jer se tako može slomiti uložak ili oštetiti brizgalica.