FrancophonIA/ELRC3.0 huggingface dataset:
English: Tyrosine kinase inhibitors such as dasatinib and nilotinib, also vincristine and vinblastine
Croatian: Inhibitori tirozin kinaze, kao što su dasatinib i nilotinib, također vinkristin i vinblastin
English: If you forget to take Zydelig
Croatian: Ako ste zaboravili uzeti Zydelig
English: Study 101-08/99 enrolled 64 subjects with previously untreated CLL, including 5 subjects with small lymphocytic lymphoma (SLL).
Croatian: Ispitivanje 101-08/99 uključilo je 64 ispitanika s prethodno neliječenom KLL, uključujući i 5 ispitanika s limfomom malih limfocita (SLL, small lymphocytic lymphoma).
English: Of the 53 subjects who did not respond, 41 (32.8%) had stable disease, 10 (8.0%) had progressive disease, and 2 (1.6%) were not evaluable.
Croatian: Od 53 ispitanika koji nisu odgovorili na liječenje, 41 (32,8%) je imao stabilnu bolest, 10 (8,0%) ih je imalo progresivnu bolest, a 2 (1,6%) nisu bila procjenjiva.
English: Zydelig is a cancer medicine that contains the active substance idelalisib.
Croatian: Zydelig je lijek protiv raka koji sadrži djelatnu tvar idelalisib.
English: The plasma exposures (Cmax and AUC) of idelalisib are approximately dose proportional between 50 mg and 100 mg and less than dose proportional above 100 mg.
Croatian: Izloženost idelalisibu u plazmi (Cmax i AUC) približno je proporcionalna dozi između 50 mg i 100 mg, a manja je nego proporcionalna dozi pri primjeni više od 100 mg.
English: • if you have a new or worsening cough
Croatian: • ako Vam se javi ili pogorša kašalj
English: Treatment with Zydelig must be withheld in the event of suspected pneumonitis.
Croatian: Liječenje Zydeligom mora se prekinuti u slučaju sumnje na pneumonitis.
English: ** Idelalisib-induced lymphocytosis should not be considered progressive disease in the absence of other clinical findings (see section 5.1).
Croatian: ** Limfocitoza prouzročena idelalisibom ne smije se smatrati progresivnom bolešću u odsutnosti drugih kliničkih nalaza (vidjeti dio 5.1).
English: Animal studies indicate the potential for harmful effects of idelalisib on fertility and foetal development (see section 5.3).
Croatian: Ispitivanja na životinjama ukazuju na mogućnost štetnog utjecaja idelalisiba na plodnost i fetalni razvoj (vidjeti dio 5.3).
English: If overdose occurs the patient must be monitored for evidence of toxicity (see section 4.8).
Croatian: Ako dođe do predoziranja, bolesnik mora biti pod nadzorom kako bi se uočili znakovi toksičnosti (vidjeti dio 4.8).
English: FL subset (N=72) n (%)
Croatian: Podskupina s FL-om (N = 72) n (%)
English: Women of childbearing potential must use highly effective contraception while taking idelalisib and for 1 month after stopping treatment (see section 4.6).
Croatian: Žene reproduktivne dobi moraju koristiti visoko učinkovitu kontracepciju dok uzimaju idelalisib i još mjesec dana nakon prestanka liječenja (vidjeti dio 4.6).
English: However, idelalisib did not inhibit the normal host response to Staphylococcus aureus and did not exacerbate the myelosuppressive effect of cyclophosphamide.
Croatian: Ipak, idelalisib nije inhibirao normalan odgovor domaćina na Staphylococcus aureus niti je pogoršao mijelosupresivni učinak ciklofosfamida.
English: Cases of severe drug-related colitis occurred relatively late (months) after the start of therapy, sometimes with rapid aggravation, but resolved within a few weeks with dose interruption and additional symptomatic treatment (e.g., anti-inflammatory agents such as enteric budesonide).
Croatian: Slučajevi teškog kolitisa povezanog s primjenom lijeka pojavljivali su se relativno kasno (mjesecima) nakon početka liječenja, ponekad s brzim pogoršanjem, ali su se povukli unutar nekoliko tjedana od prekida uzimanja uz dodatno simptomatsko liječenje (npr. protuupalni lijekovi kao što je enterična formulacija budezonida).
English: Intensified monitoring of adverse reactions is recommended in patients with impaired hepatic function as exposure is expected to be increased in this population, in particular in patients with severe hepatic impairment.
Croatian: U bolesnika s oštećenom funkcijom jetre preporučuje se pojačani nadzor zbog nuspojava budući da se u ovoj populaciji očekuje povećana izloženost, posebice u bolesnika s teškim oštećenjem funkcije jetre.
English: Female fertility was not affected in rats.
Croatian: Nije bilo utjecaja na plodnost u ženki štakora.
English: In vitro, the CYP3A4 inhibition was irreversible, and return to normal enzyme activity is therefore expected to take several days after stopping idelalisib administration.
Croatian: In vitro je CYP3A4 inhibicija bila ireverzibilna te se stoga očekuje da će za povratak normalne enzimske aktivnosti nakon prestanka primjene idelalisiba biti potrebno nekoliko dana.
English: For subjects in the placebo + R group, the summary includes data up to the first dosing of idelalisib in an extension study.
Croatian: Za ispitanike u skupini placebo + R, kratak pregled uključuje podatke do primjene prve doze idelalisiba u produžetku ispitivanja.
English: Treatment may be resumed at a lower dose once values have returned to Grade 1 or below (ALT/AST ≤ 3 x ULN).
Croatian: Liječenje se može nastaviti nižim dozama kada se vrijednosti vrate na 1. stupanj ili niže (ALT/AST ≤ 3 x GGN).
English: • rifabutin, a medicine used to treat bacterial infections including tuberculosis
Croatian: • rifabutin, lijek koji se primjenjuje za liječenje bakterijskih infekcija uključujući tuberkulozu
English: Of the 125 subjects enrolled, 80 (64%) were male, the median age was 64 years (range: 33 to 87), and 110 (89%) were white.
Croatian: Od 125 uključenih ispitanika, 80 (64%) su bili muškarci, medijan dobi iznosio je 64 godine (raspon: 33 do 87), a 110 (89%) su bili bijelci.
English: Severe skin blistering conditions have been reported in some people who have received Zydelig while also receiving other medicines known to cause these potentially life-threatening conditions.
Croatian: Zabilježena su teška stanja s mjehurima na koži u nekih osoba koje su Zydelig primale istovremeno s drugim lijekovima za koje se zna da uzrokuju ta stanja koja mogu biti opasna po život.
English: Degeneration of the seminiferous tubules in the testes was observed in 2- to 13-week repeated dose studies in dogs and rats, but not in studies of 26 weeks and longer duration.
Croatian: Degeneracija sjemenih kanalića u testisima zabilježena je u ispitivanjima ponovljenih doza u pasa i štakora koja su trajala 2 - 13 tjedana, ali ne u onima koja su trajala 26 tjedana i duže.
English: If the benefits of resuming idelalisib are judged to outweigh the risks, consideration should be given to administering pre-emptive CMV therapy.
Croatian: Ako se procijeni da koristi nastavljanja liječenja idelalisibom nadmašuju rizike, potrebno je razmotriti primjenu preemptivne terapije CMV-a.
English: Zydelig may be prescribed in combination with other medicines for the treatment of CLL.
Croatian: Zydelig se može propisati u kombinaciji s drugim lijekovima za liječenje KLL.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with idelalisib in one or more subsets of the paediatric population in the treatment of mature B-cell neoplasms (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja idelalisiba u jednoj ili više podskupina pedijatrijske populacije u liječenju neoplazmi zrelih B-stanica (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: The carcinogenicity potential of idelalisib was evaluated in a 26-week transgenic RasH2 mouse study and a 2-year rat study.
Croatian: Kancerogeni potencijal idelalisiba procijenjen je u 26-tjednom ispitivanju na RasH2 transgeničnim miševima te u dvogodišnjem ispitivanju na štakorima.
English: No initial dose adjustment of idelalisib is considered necessary when administered with CYP3A/P-gp inhibitors, but an intensified monitoring of adverse reactions is recommended.
Croatian: Smatra se da nije potrebna prilagodba početne doze idelalisiba kada se primjenjuje s CYP3A/P-gp inhibitorima, ali se preporučuje pojačani nadzor zbog nuspojava.
English: Infections and infestations Infections (including Pneumocystis jirovecii pneumonia and CMV)*
Croatian: Infekcije i infestacije Infekcije (uključujući pneumoniju izazvanu uzročnikom Pneumocystis jirovecii i infekciju CMV-om)*
English: • pimozide, a medicine used to treat abnormal thoughts or feelings
Croatian: • pimozid, lijek koji se primjenjuje za liječenje abnormalnih misli i osjećaja
English: If either moderate or severe symptomatic pneumonitis or organising pneumonia is diagnosed, appropriate treatment should be initiated and idelalisib must be permanently discontinued.
Croatian: Ako su dijagnosticirani umjereni ili teški simptomatski pneumonitis ili organizirajuća pneumonija, potrebno je započeti prikladno liječenje te trajno prekinuti idelalisib.
English: Thus, idelalisib has the potential to interact with medicinal products that are metabolised by CYP3A, which may lead to increased serum concentrations of the other product (see section 4.5).
Croatian: Stoga idelalisib može ući u interakcije s lijekovima koje metabolizira CYP3A, što može dovesti do povećane serumske koncentracije drugog lijeka (vidjeti dio 4.5).
English: Women of childbearing potential / contraception
Croatian: Žene reproduktivne dobi / kontracepcija
English: If you accidentally take more than the recommended dose of Zydelig, you may be at increased risk of side effects with this medicine (see section 4, Possible side effects).
Croatian: Ako slučajno uzmete više Zydeliga nego što je preporučena doza, rizik od nuspojava kod Vas može biti povećan (pogledajte dio 4, Moguće nuspojave).
English: Grade ≥ 3
Croatian: ≥ 3. stupanj
English: Clinical monitoring is recommended for patients with CrCl < 90 mL/min.
Croatian: Preporučuje se kliničko praćenje bolesnika s CrCl < 90 ml/min.
English: The combination may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations, and sinus tachycardia.
Croatian: Ta kombinacija može dovesti do povećanog rizika od kardiovaskularnih nuspojava povezanih sa salmeterolom, uključujući produljenje QT intervala, palpitacije i sinusnu tahikardiju.
English: If PML is suspected then appropriate diagnostic evaluations should be undertaken and treatment suspended until PML is excluded.
Croatian: Posumnja li se na PML, potrebno je provesti prikladne dijagnostičke pretrage i prekinuti liječenje dok se PML ne isključi.
English: Table 7: Summary of efficacy in Study 101-09 (IRC assessment) Characteristic
Croatian: Tablica 7: Kratak pregled djelotvornosti u ispitivanju 101-09 (IRC procjena) Obilježje
English: In vitro, idelalisib both inhibited and induced CYP2C8, but it is not known whether this translates to an in vivo effect on CYP2C8 substrates.
Croatian: In vitro, idelalisib je i inhibirao i inducirao CYP2C8, ali nije poznato prenosi li se to na in vivo učinak na CYP2C8 supstrate.
English: Chronic hepatitis
Croatian: Kronični hepatitis
English: The effect of idelalisib (150 mg and 400 mg) on the QT/QTc interval was evaluated in a placebo- and positive-controlled (moxifloxacin 400 mg) crossover study in 40 healthy subjects.
Croatian: Učinak idelalisiba (150 mg i 400 mg) na QT/QTc interval ocijenjen je crossover ispitivanjem kontroliranim placebom i pozitivnom kontrolom (moksifloksacin 400 mg) u 40 zdravih ispitanika.
English: The median OS, including long-term follow-up for all FL subjects was 61.2 months.
Croatian: Medijan OS-a, uključujući dugotrajno praćenje svih ispitanika s FL-om, iznosio je 61,2 mjeseca.
English: Rash typically resolved with treatment (e.g., topical and/or oral steroids, diphenhydramine) and dose interruption for severe cases (see section 5.3, phototoxicity).
Croatian: Osip se obično povukao uz liječenje (npr. topikalni i/ili oralni steroidi, difenhidramin) i prekid uzimanja lijeka u teškim slučajevima (vidjeti dio 5.3, fototoksičnost).
English: In studies up to 4 weeks in rats and dogs, hepatic necrosis was observed at 7 and 5 times the human exposure based on AUC, respectively.
Croatian: U ispitivanjima u trajanju do 4 tjedna u štakora i pasa zabilježena je nekroza jetre pri 7 odnosno 5 puta većoj izloženosti (temeljenoj na AUC) od izloženosti ljudi.
English: The primary endpoint was progression free survival (PFS).
Croatian: Primarna mjera ishoda bila je preživljenje bez progresije bolesti (PFS, progression free survival).
English: ALT, AST, and total bilirubin must be monitored in all patients every 2 weeks for the first 3 months of treatment, then as clinically indicated.
Croatian: Vrijednosti ALT, AST i ukupnog bilirubina moraju se pratiti u svih bolesnika svaka 2 tjedna u prva 3 mjeseca liječenja, a potom prema kliničkoj indikaciji.
English: Idelalisib was taken until disease progression or unacceptable toxicity.
Croatian: Idelalisib se uzimao do progresije bolesti ili neprihvatljive toksičnosti.
English: Monitor ANC at least weekly.
Croatian: Pratite ABN najmanje jedanput tjedno.
English: The onset of isolated lymphocytosis typically occurs during the first 2 weeks of idelalisib therapy and is often associated with reduction of lymphadenopathy.
Croatian: Izolirana limfocitoza obično započne tijekom prva 2 tjedna terapije idelalisibom i često je povezana sa smanjenjem limfadenopatije.
English: Potential interactions between idelalisib and co-administered medicinal products that are CYP3A substrates are listed in Table 1 (increase is indicated as “↑”).
Croatian: Moguće interakcije između idelalisiba i istovremeno primijenjenih lijekova koji su CYP3A supstrati navedene su u tablici 1 (povećanje je označeno s “↑”).
English: In follicular lymphoma, the B-lymphocytes multiply too quickly and live for too long, so there are too many of them in the lymph nodes.
Croatian: U folikularnom limfomu, B limfociti se prebrzo umnožavaju i predugo žive, tako da ih je previše u limfnim čvorovima.
English: ANC < 500/mm3
Croatian: ABN < 500/mm3
English: In addition, 86 subjects from this study who were randomised to receive placebo + rituximab went on to receive idelalisib as a single agent in an extension study (study 312-0117).
Croatian: Nadalje, 86 ispitanika u ovom ispitivanju koji su bili randomizirani da primaju placebo + rituksimab nastavilo je primati idelalisib kao monoterapiju u produžetku ispitivanja (ispitivanje 312-0117).
English: High density polyethylene (HDPE) bottle, capped with a polypropylene child-resistant closure, containing 60 film-coated tablets and a polyester coil.
Croatian: Boca izrađena od polietilena visoke gustoće (HDPE), zatvorena polipropilenskim sigurnosnim zatvaračem za djecu, sadrži 60 filmom obloženih tableta i poliesterski smotuljak.
English: Zydelig is indicated as monotherapy for the treatment of adult patients with follicular lymphoma (FL) that is refractory to two prior lines of treatment (see section 4.4).
Croatian: Zydelig je indiciran kao monoterapija za liječenje odraslih bolesnika s folikularnim limfomom (FL) refrakternim na dvije prethodne linije liječenja (vidjeti dio 4.4).
English: Amlodipine, diltiazem, felodipine, nifedipine, nicardipine
Croatian: Amlodipin, diltiazem, felodipin, nifedipin, nikardipin
English: ^ Overall survival (OS) analysis includes data from subjects who received placebo + R on study 312-0116 and subsequently received idelalisib in an extension study, based on intent-to-treat analysis.
Croatian: ^ Analiza ukupnog preživljenja (OS, overall survival) uključuje podatke o ispitanicima koji su primali placebo + R u ispitivanju 312-0116 i koji su poslije primali idelalisib u produžetku ispitivanja, na temelju analize prema namjeri liječenja.
English: Caution should be exercised when administering Zydelig in patients with active hepatitis.
Croatian: Potreban je oprez pri primjeni Zydeliga u bolesnika s aktivnim hepatitisom.
English: Idelalisib has not been studied in patients with chronic active hepatitis including viral hepatitis.
Croatian: Idelalisib nije ispitan u bolesnika s kroničnim aktivnim hepatitisom, uključujući virusni hepatitis.
English: Population pharmacokinetic analyses indicated that gender and race had no clinically relevant effect on the exposures to idelalisib or GS-563117.
Croatian: Populacijska analiza farmakokinetike pokazala je da spol i rasa nemaju klinički značajan učinak na izloženost idelalisibu ili GS-563117.
English: The median DOR for all subjects was 12.5 months (12.5 months for SLL subjects, and 11.8 months for FL, 20.4 months for LPL/WM and 18.4 months for MZL subjects).
Croatian: Medijan DOR-a za sve ispitanike iznosio je 12,5 mjeseci (12,5 mjeseci za ispitanike sa SLL, a 11,8 mjeseci za ispitanike s FL, 20,4 mjeseca za ispitanike s LPL/WM i 18,4 mjeseca za ispitanike s MZL).
English: • if you have redness and blistering of the skin
Croatian: • ako imate crvenilo i mjehure na koži
English: Do not use this medicine after the expiry date which is stated on the bottle and carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na boci ili kutiji iza „Rok valjanosti“.
English: Caution is recommended when administering Zydelig in this population.
Croatian: Potreban je oprez pri primjeni Zydeliga u ovoj populaciji.
English: • atorvastatin, lovastatin, simvastatin, medicines used to lower cholesterol
Croatian: • atorvastatin, lovastatin, simvastatin, lijekovi koji se primjenjuju za snižavanje kolesterola
English: INHALED BETA AGONIST
Croatian: INHALACIJSKI BETA AGONIST Salmeterol
English: Zydelig can cause lung inflammation.
Croatian: Zydelig može uzrokovati upalu pluća.
English: Idelalisib can be administered without regard to food.
Croatian: Idelalisib se može uzimati bez obzira na hranu.
English: Efficacy results are summarised in Table 7.
Croatian: Rezultati djelotvornosti prikazani su u tablici 7.
English: A risk for P-gp inhibition in the gastrointestinal tract, that could result in increased exposure of sensitive substrates for intestinal P-gp such as dabigatran etexilate, cannot be excluded.
Croatian: Ne može se isključiti rizik od P-gp inhibicije u gastrointestinalnom traktu, koja može dovesti do povećane izloženosti osjetljivim supstratima crijevnog P-gp, kao što je dabigatraneteksilat.
English: Zydelig is unlikely to affect your ability to drive or use machines.
Croatian: Nije vjerojatno da će uzimanje Zydeliga utjecati na Vašu sposobnost upravljanja vozilima i rada sa strojevima.
English: The recommended dose is 150 mg by mouth twice a day.
Croatian: Preporučena doza je 150 mg uzeta kroz usta dva puta na dan.
English: There is a potential risk that idelalisib, via its major metabolite, GS-563117, may cause photosensitivity in treated patients.
Croatian: Postoji mogući rizik da bi idelalisib, putem svog glavnog metabolita, GS-563117, mogao uzrokovati fotoosjetljivost u liječenih bolesnika.
English: Treatment with Zydelig must be withheld in the event of a Grade 3 or 4 aminotransferase elevation (alanine aminotransferase [ALT]/aspartate aminotransferase [AST] > 5 x upper limit of normal [ULN]).
Croatian: Liječenje Zydeligom mora se prekinuti u slučaju povišenja vrijednosti aminotransferaza 3. ili 4. stupnja (alanin aminotransferaza [ALT]/aspartat aminotransferaza [AST] > 5 x iznad gornje granice normale [GGN]).
English: ↑ serum concentrations Careful dose titration of the antidepressant and monitoring for antidepressant response is recommended.
Croatian: ↑ koncentracije u serumu Preporučuje se pažljiva titracija doze antidepresiva i praćenje odgovora na antidepresiv.
English: Tell your doctor if you have an allergy to sunset yellow FCF (E110).
Croatian: Recite svom liječniku ako ste alergični na boju sunset yellow FCF (E110).
English: No specific dose adjustment is required for elderly patients (aged ≥ 65 years) (see section 5.2).
Croatian: Nije potrebna posebna prilagodba doze za starije bolesnike (u dobi od ≥ 65 godina) (vidjeti dio 5.2).
English: Solid line: idelalisib + O (N = 174), dashed line: ofatumumab (N = 87) O: ofatumumab; N: number of subjects per group
Croatian: Puna crta: idelalisib + O (N = 174), isprekidana crta: ofatumumab (N = 87) O: ofatumumab; N: broj ispitanika u skupini
English: The duration of post-treatment prophylaxis should be based on clinical judgment and may take into account a patient's risk factors such as concomitant corticosteroid treatment and prolonged neutropenia (see section 4.8).
Croatian: Trajanje profilakse nakon liječenja treba temeljiti na kliničkoj procjeni te se mogu uzeti u obzir rizični čimbenici u bolesnika kao što su istodobno liječenje kortikosteroidima ili produljena neutropenija (vidjeti dio 4.8).
English: Compared with rituximab + placebo, treatment with idelalisib + rituximab resulted in statistically significant and clinically meaningful improvements in physical well-being, social well-being, functional well-being, as well as in the leukaemia-specific subscales of the Functional Assessment of Cancer Therapy: Leukaemia (FACT-LEU) instruments, and in statistically significant and clinically meaningful improvements in anxiety, depression and usual activities as measured by the EuroQoL Five-Dimensions (EQ-5D) instrument.
Croatian: U usporedbi s rituksimabom + placebom, liječenje s idelalisibom + rituksimabom pokazalo je statistički značajna i klinički važna poboljšanja fizičkog, socijalnog i funkcionalnog stanja, kao i poboljšanje na podljestvicama specifičnima za leukemiju (FACT-LEU) instrumenta za Funkcionalnu procjenu terapije raka te statistički značajna i klinički važna poboljšanja anksioznosti, depresije i uobičajenih aktivnosti mjereno Europskim upitnikom za procjenu kvalitete života (EQ-5D).
English: Clinical monitoring is recommended for telithromycin.
Croatian: Preporučuje se kliničko praćenje za telitromicin.
English: A dose-related increase in pancreatic islet cell tumors was observed at low incidence in male rats at exposures up to 0.4-fold compared to the human exposure at the recommended dose; a similar finding was not observed in female rats at 0.62-fold exposure margin.
Croatian: U mužjaka štakora opažena je niska incidencija tumora stanica pankreasnih otočića gušterače s povećanjem ovisnim o dozi pri izloženosti koja iznosi do 0,4 puta vrijednosti izloženost u ljudi pri preporučenoj dozi; slični nalazi nisu opaženi u ženki štakora pri granici izloženosti od 0,62 puta.
English: Amiodarone, quinidine
Croatian: ANTIARITMICI Amiodaron, kinidin
English: Since a reduction in idelalisib plasma concentrations may result in decreased efficacy, co-administration of Zydelig with moderate or strong CYP3A inducers should be avoided (see section 4.5).
Croatian: Budući da smanjena koncentracija idelalisiba u plazmi može dovesti do smanjene djelotvornosti, treba izbjegavati istovremenu primjenu Zydeliga s umjerenim ili jakim CYP3A induktorima (vidjeti dio 4.5).
English: There is insufficient data to make dose recommendations for patients with severe hepatic impairment.
Croatian: Nema dovoljno podataka za određivanje preporučenih doza za bolesnike s teškim oštećenjem funkcije jetre.
English: If SJS or TEN is suspected, idelalisib should be immediately interrupted and the patient treated accordingly.
Croatian: Ako se sumnja na SJS ili TEN, potrebno je odmah prekinuti primjenu idelalisiba i bolesnika odgovarajuće liječiti.
English: * ORR defined as the proportion of subjects who achieved a complete response (CR) or partial response (PR) and maintained their response for at least 8 weeks.
Croatian: * ORR je definiran kao udio ispitanika koji su postigli potpuni odgovor (CR, od engl. complete response) ili parcijalni odgovor (PR, od engl. partial response) i u kojih je taj odgovor bio održan najmanje 8 tjedana.
English: Trazodone
Croatian: Trazodon
English: Particular caution must be used and dose reduction may be considered when prescribing sildenafil or tadalafil with idelalisib with increased monitoring for adverse events.
Croatian: Potreban je poseban oprez i može se razmotriti sniženje doze kad se sildenafil ili tadalafil propisuju s idelalisibom uz pojačan nadzor zbog nuspojava.