FrancophonIA/ELRC3.0 huggingface dataset:
English: If dose adjustments of concomitant medicinal products are made due to treatment with dasabuvir and ombitasvir/paritaprevir/ritonavir, doses should be re-adjusted after administration of dasabuvir and ombitasvir/paritaprevir/ritonavir is completed.
Danish: Hvis dosisjustering af samtidigt administrerede lægemidler skyldes behandlingen med dasabuvir og ombitasvir/paritaprevir/ritonavir, skal der ske fornyet dosisjustering, når behandlingen med Exviera og ombitasvir/paritaprevir/ritonavir er afsluttet.
English: Note: The following variants were selected in cell culture but were not treatment-emergent: NS3 variants A156T in genotype 1a, and R155Q and D168H in genotype 1b; NS5A variants Y93C/H in genotype 1a, and
Danish: Bemærk: Følgende varianter blev selekteret i cellekultur, men var ikke behandlingsrelaterede: NS3varianter: A156T hos genotype 1a samt R155Q og D168H hos genotype 1b. NS5A-varianter: Y93C/H hos genotype 1a og L31F/V eller Y93H i kombination med L28M, L31F/V eller P58S hos genotype 1b. Og NS5B-varianter: Y448H hos genotype 1a samt M414T og Y448H hos genotype 1b.
English: In subjects with all three favourable baseline laboratory values (AFP < 20 ng/mL, platelets ≥ 90 x 109/L, and albumin ≥ 35 g/L), relapse rates were similar in subjects treated for 12 or 24 weeks.
Danish: trombocyttal ≥ 90 x 109/l og albumin ≥ 35 g/l), var recidivraten den samme for patienter behandlet i henholdsvis 12 og 24 uger.
English: Phase 3 global multicentre trials conducted with dasabuvir and ombitasvir/paritaprevir/ritonavir with or without ribavirin (RBV).
Danish: Globale, multicenter-, fase 3-studier med dasabuvir og ombitasvir/ paritaprevir/ritonavir med eller uden ribavirin (RBV).
English: To be noted, atazanavir should be taken without ritonavir, since ritonavir 100 mg once daily is provided as part of the ombitasvir/paritaprevir/ritonavir fixed dose combination.
Danish: Bemærk, at atazanavir skal tages uden ritonavir, da ritonavir 100 mg én gang dagligt indgår i den faste ombitasvir/paritaprevir/ritonavir-dosis.
English: AbbVie Deutschland GmbH & Co. KG Knollstrasse
Danish: AbbVie Deutschland GmbH & Co.
English: See section 4.2 for dosing recommendations in HCV/HIV-1 co-infected patients.
Danish: 4.2 for doseringsanbefalinger hos patienter med HCV og samtidig hiv-1-infektion.
English: Without cirrhosis
Danish: Uden cirrose
English: Liver transplant subjects with cirrhosis were dosed with dasabuvir and ombitasvir/paritaprevir/ritonavir with RBV (GT1a for 24 weeks [n=4], GT1b for 12 weeks [n=2]).
Danish: Levertransplanterede forsøgspersoner med cirrose blev doseret med dasabuvir og ombitasvir/paritaprevir/ritonavir med RBV (GT1a i 24 uger [n = 4], GT1b i 12 uger [n = 2]).
English: HCV ANTIVIRAL Sofosbuvir
Danish: ANTIVIRALTMIDDEL MOD HEPATITIS C-VIRUS Sofosbuvir
English: A pooled analysis of subjects with genotype 1 HCV infection, who were treated with dasabuvir, ombitasvir and paritaprevir with or without ribavirin in Phase 2b and 3 clinical trials, was conducted to explore the association between baseline NS3/4A, NS5A or NS5B substitutions/polymorphisms and treatment outcome in these recommended regimens.
Danish: Virkning af baseline-HCV-substitutioner/polymorfismer på behandlingsrespons Der blev gennemført en samlet analyse af de forsøgspersoner med genotype 1 HCV-infektion, der blev behandlet med dasabuvir, ombitasvir og paritaprevir med eller uden ribavirin i fase 2b- og fase 3studierne, for at undersøge sammenhængen mellem NS3/4A-, NS5A- eller NS5Bsubstitutioner/polymorfismer ved baseline og behandlingsresultatet af de anbefalede regimer.
English: In genotype 1b, substitutions C316N, C316Y, M414T, Y448H, and S556G in HCV NS5B reduced susceptibility to dasabuvir.
Danish: I genotype 1b reducerede substitutionerne C316N, C316Y, M414T, Y448H og S556G i HCV-NS5B følsomheden over for dasabuvir.
English: Table 18.
Danish: Tabel 18.
English: Selected treatment emergent laboratory abnormalities
Danish: Udvalgte behandlingsrelaterede afvigelser i laboratorieværdierne
English: Strong CYP2C8 inhibitors are contraindicated with dasabuvir (see section 4.3 and Table 2).
Danish: Stærke CYP2C8-hæmmere er kontraindicerede sammen med dasabuvir (se pkt.
English: Treated subjects (N = 233) had a median age of 49 years (range: 26 to 69); 10% were Black; 12% had compensated cirrhosis; 66% were treatment-naïve; 32% had failed prior treatment with pegIFN/RBV; 2% had failed prior treatment with sofosbuvir.
Danish: De behandlede forsøgspersoner (N = 233) havde en gennemsnitsalder på 49 år (interval: 26-69), 10 % var sorte, 12 % havde kompenseret cirrose, 66 % var behandlingsnaive, 32 % havde oplevet behandlingssvigt med pegIFN/RBV inden behandling, og 2 % havde haft behandlingssvigt med sofosbuvir inden behandling.
English: Use of ethinyloestradiol-containing medicinal products such as those contained in most combined oral contraceptives or contraceptive vaginal rings (see sections 4.4 and 4.5).
Danish: Brug af lægemidler med ethinyløstradiol som f.eks. de fleste kombinerede p-piller eller p-ringe (se pkt.
English: Subjects with HCV GT4 received ombitasvir/paritaprevir/ritonavir with ribavirin for 12 or 24 Weeks.
Danish: Forsøgspersoner med HCV GT4 fik ombitasvir/paritaprevir/ritonavir med ribavirin i 12 eller 24 uger.
English: Table 17.
Danish: Tabel 17.
English: If statin treatment is required during the treatment period, a switch to a reduced dose of pravastatin/rosuvastatin is possible (see section 4.5, Table 2).
Danish: Hvis det er nødvendigt at give patienten statiner i behandlingsperioden, er det muligt at skifte til en reduceret dosis af pravastatin/rosuvastatin (se pkt.
English: Table 11.
Danish: Tabel 11.
English: The activity of dasabuvir was reduced by 5- and 11-fold by C316N and S556G, respectively; 46-fold by M414T or Y448H; and 1569-fold by the C316Y substitutions in the genotype 1b replicon.
Danish: Aktiviteten af dasabuvir blev reduceret med henholdsvis 5 og 11 gange af C316Nog S556G-substitutioner, 46 gange af M414T- eller Y448H-substitutioner og 1.569 gange af C316Ysubstitutioner i genotype 1b-replikonen.
English: Treated subjects (N=68) had a median age of 58 years (range: 32-77 years); 83.8% were male; 58.8% were Black; 73.5% of subjects were infected with HCV GT1a; 75.0%% had Stage 5 CKD and 69.1% were on haemodialysis.
Danish: De behandlede patienter (N = 68) havde en median alder på 58 år (interval: 32-77 år); 83,8% var mænd; 58,8% var sorte; 73,5% af patienterne var inficeret med HCV GT1a; 75,0 % havde CKDstadium 5 og 69,1% var i hæmodialyse.
English: BIGUANIDE ORAL ANTIHYPERGLYCEMICS Metformin
Danish: ORALE ANTIDIABETIKA, BIGUANIDER Metformin
English: Enzyme inducers
Danish: Enzym-inducere
English: NA No dose adjustment required for carisoprodol; increase dose if clinically indicated.
Danish: Ikke relevant Dosisjustering er ikke nødvendig for for carisoprodol; øgning af dosis, hvis klinisk indiceret
English: Use with statins
Danish: Samtidig brug af statiner
English: Exviera contains lactose
Danish: Exviera indeholder laktose
English: They are always taken with another antiviral medicine containing ombitasvir/paritaprevir/ritonavir.
Danish: De tages altid sammen med et andet antiviralt lægemiddel, der indeholder ombitasvir/paritaprevir/ritonavir.
English: 5 mg single dose and other vitamin K antagonists dasabu vir +
Danish: 5 mg enkeltdosis og andre vitamin Kantagonister
English: Table 15.
Danish: Tabel 15.
English: Medicinal products metabolised by CYP2C9
Danish: Lægemidler, der metaboliseres af CYP2C9
English: Table 12.
Danish: Tabel 12.
English: Dasabuvir should not be used in patients with moderate to severe hepatic impairment (Child-Pugh B or C) (see section 5.2).
Danish: Dasabuvir bør ikke anvendes hos patienter med moderat til svær nedsat leverfunktion (Child-Pugh B eller C) (se pkt.
English: Take one tablet in the morning.
Danish: Oral anvendelse Tag én tablet om morgenen.
English: dasabuvir + ombitasvir/paritaprevir/ritonavir was administered as multiple doses in all the drug interaction studies except the drug interaction studies with carbamazepine, gemfibrozil, ketoconazole, and sulfamethoxazole/trimethoprim.
Danish: Den opnåede dasabuvir-eksponering var af samme størrelsesorden for formuleringen på 400 mg og for tabletter på 250 mg. dasabuvir + ombitasvir/paritaprevir/ritonavir blev administreret som multiple doser i alle lægemiddelinteraktionsstudierne, bortset fra lægemiddelinteraktionsstudierne med carbamazepin, gemfibrozil, ketoconazol og sulfamethoxazol/trimethoprim.
English: Table 13.
Danish: Tabel 13.
English: 30 mg once daily single dose3
Danish: 30 mg enkeltdosis én gang dagligt3
English: Medicinal products that inhibit CYP2C8
Danish: Lægemidler, der hæmmer CYP2C8
English: PROTON PUMP INHIBITORS Omeprazole
Danish: PROTONPUMPEHÆMMERE Omeprazol
English: Medicinal products metabolised by CYP2C19
Danish: Lægemidler, der metaboliseres af CYP2C19
English: How to take Exviera
Danish: Sådan skal du tage Exviera
English: 0.75 mg single dose
Danish: 0,75 mg enkeltdosis
English: If tacrolimus or sirolimus are used together with dasabuvir and ombitasvir/paritaprevir/ritonavir, caution is advised, and recommended doses and monitoring strategies can be found in section 4.5.
Danish: Der tilrådes forsigtighed, hvis tacrolimus eller sirolimus anvendes sammen med dasabuvir og ombitasvir/paritaprevir/ritonavir og anbefalede doser og overvågningsstrategier findes i pkt.
English: No dose adjustment of dasabuvir is warranted in elderly patients (see section 5.2).
Danish: Ældre Det er ikke nødvendigt at justere dosis af dasabuvir hos ældre patienter (se pkt.
English: Table 14.
Danish: Tabel 14.
English: Peg-IFN + RBV, n (%) Baseline albumin, median g/L < 35, n (%)
Danish: Alder, median (interval) år Mænd, køn, n (%) Tidligere HCV-behandling: naïve, n (%) Peg-IFN + RBV, n (%) Baseline albumin, median g/l < 35, n (%)
English: Desmethyl citalopram
Danish: desmethylcitalopram
English: Side effects when taking Exviera with ombitasvir/paritaprevir/ritonavir with or without ribavirin:
Danish: Bivirkninger ved indtagelse af Exviera med ombitasvir/paritaprevir/ritonavir med eller uden ribavirin:
English: NARCOTIC ANALGESICS Paracetamol (given as fixed dose hydrocodone /paracetamol dasabu vir +
Danish: OPIOIDER ANALGETIKA Paracetamol (givet som fast doseret hydrokodon/p aracetamol)
English: In Part 1b, all subjects received dasabuvir and ombitasvir/paritaprevir/ritonavir with ribavirin for 12 weeks.
Danish: I del 1b blev alle forsøgspersoner behandlet med dasabuvir og ombitasvir/paritaprevir/ritonavir med ribavirin i 12 uger.
English: NA No dose adjustment for cyclobenzaprine required; increase dose if clinically indicated.
Danish: NA Dosisjustering er ikke nødvendig for cyclobenzaprin; øgning af dosis, hvis klinisk indiceret
English: Subjects with liver transplant and GT4 infection were dosed with ombitasvir/paritaprevir/ritonavir with RBV (noncirrhotic for 12 weeks [n=2] and cirrhotic for 24 weeks [n=1].
Danish: Levertransplanterede forsøgspersoner med GT4-infektion blev doseret med ombitasvir/paritaprevir/ritonavir med RBV (uden cirrose i 12 uger [n = 2] og med cirrose i 24 uger [n = 1].
English: The recommended dose of atazanavir is 300 mg, without ritonavir, in combination with dasabuvir + ombitasvir/paritaprevir/ ritonavir.
Danish: Den anbefalede dosis atazanavir er 300 mg, uden ritonavir, i kombination med dasabuvir med ombitasvir/paritatprevir/
English: Esomeprazol e
Danish: Esomeprazol
English: Geometric mean Cmax, AUC of multiple doses of dasabuvir 250 mg twice daily and ombitasvir/paritaprevir/ritonavir 25 mg/150 mg/100 mg once daily with food in healthy volunteers
Danish: Geometrisk gennemsnit af Cmax og AUC for multiple doser af dasabuvir 250 mg to gange dagligt og ombitasvir/paritaprevir/ritonavir 25 mg/150 mg/100 mg én gang dagligt sammen med mad hos raske forsøgspersoner
English: In genotype 1a, substitutions C316Y, M414T, Y448H, A553T, G554S, S556G/R, and Y561H in HCV NS5B reduced susceptibility to dasabuvir.
Danish: I genotype 1a reducerede substitutionerne C316Y, M414T, Y448H, A553T, G554S, S556G/R og Y561H i HCV-NS5B følsomheden over for dasabuvir.
English: Mechanism: possible enzyme induction by efavirenz.
Danish: Mekanisme: Muligvis efavirenz' enzyminducerende virkning.
English: Compared to subjects without cirrhosis, in subjects with compensated cirrhosis there was an increased rate of indirect hyperbilirubinemia when ribavirin was part of the regimen.
Danish: Der var en øget hyppighed af inddirekte hyperbilirubinæmi hos patienter med cirrose sammenlignet med patienter uden cirrose, når ribavirin var en del af behandlingsregimet
English: 95% CIa F0-F1
Danish: 95% CIa
English: Mechanism: OATP1B/BC RP inhibition by paritaprevir.
Danish: Mekanisme: Paritaprevirs hæmning af OATP1B/BC RP.
English: Everolimus cannot be used due to lack of suitable dose strengths for dose adjustments.
Danish: På grund af mangel på egnede styrker til dosisjusteringer kan everolimus ikke anvendes.
English: Ombitasvir/paritaprevir/ritonavir with or without dasabuvir was also evaluated without ribavirin in 18 GT1a- and GT4-infected patients; no adverse events of anaemia were seen in these subjects.
Danish: Hos 18 GT1a- og GT4-inficerede patienter blev Ombitasvir/paritaprevir/ritonavir med eller uden dasabuvir også undersøgt uden ribavirin; der blev ikke set anæmi-bivirkninger hos disse patienter.
English: Tacrolimus 2 mg was dosed alone and 2 mg was administered with dasabuvir + ombitasvir/paritaprevir/ritonavir.
Danish: Tacrolimus 2 mg blev administreret alene, og tacrolimus 2 mg blev administreret sammen med dasabuvir + ombitasvir/paritaprevir/ritonavir.
English: Mitotane
Danish: Mitotan
English: The effect on Cmax and AUC of DAAs and lopinavir was similar to that observed when lopinavir/ritonavir 400/100 mg twice daily was administered with dasabuvir and ombitasvir/paritaprevir/ritonavir.
Danish: Indvirkningen på Cmax og AUC af direkte virkende antivirale midler og lopinavir var af samme størrelsesorden som ved samtidig administration af lopinavir/ritonavir 400/100 mg to gange dagligt og dasabuvir med ombitasvir/paritaprevir/ritonavir.
English: Table 2 provides the Least Squares Means Ratio (90% Confidence Interval) effect on concentration of dasabuvir and ombitasvir/paritaprevir/ritonavir and concomitant medicinal products.
Danish: Tabel 2 viser indvirkningen på koncentrationen af dasabuvir og ombitasvir/paritaprevir/ritonavir og samtidigt administrerede lægemidler baseret på mindste kvadraters gennemsnit (90 %konfidensinterval).
English: Dasabuvir treatment-emergent variants M414T, G554S, S556G, G558R or D559G/N in NS5B were observed in 34 subjects.
Danish: Følgende dasabuvir-behandlingsrelaterede varianter i NS5B blev observeret hos 34 forsøgspersoner: M414T, G554S, S556G, G558R eller D559G/N.
English: No dose adjustment of dasabuvir is required for patients with mild, moderate, or severe renal impairment or end-stage-renal disease on dialysis (see section 5.2).
Danish: Det er ikke nødvendigt at justere dosis af dasabuvir hos patienter med let, moderat eller svært nedsat nyrefunktion eller hos patienter i dialyse med nyresygdom i slutstadiet (se pkt.
English: ANTIDEPRESSANTS Escitalopram 10 mg single dose dasabu vir +
Danish: ANTIDEPRESSIVA Escitalopram 10 mg enkeltdosis
English: HIV/HCV co-infected patients
Danish: Patienter med samtidig hiv- og HCV-infektion
English: Ombitasvir treatment-emergent variants M28T, M28V or Q30R in NS5A were observed in 32 subjects.
Danish: Følgende ombitasvirbehandlingsrelaterede varianter i NS5A blev observeret hos 32 forsøgspersoner: M28T, M28V eller Q30R.
English: For patients that require ribavirin, refer to the ribavirin Summary of Product Characteristics for information regarding use in patients with renal impairment.
Danish: For patienter, som skal have ribavirin, se information vedrørende nedsat nyrefunktion i produktresuméet for ribavirin.
English: Extreme caution must be taken to avoid pregnancy in female patients and female partners of male patients when dasabuvir is taken in combination with ribavirin (see section 4.6 and refer to the Summary of Product Characteristics for ribavirin for additional information).
Danish: Der skal træffes skærpede forholdsregler for at undgå graviditet hos kvindelige patienter og hos mandlige patienters kvindelige partnere, når dasabuvir administreres i kombination med ribavirin (se pkt.
English: Side effects when taking Exviera and ombitasvir/paritaprevir/ritonavir with ribavirin:
Danish: Bivirkninger ved indtagelse af Exviera sammen med ombitasvir/paritaprevir/ritonavir med ribavirin:
English: Drug interaction studies
Danish: Undersøgelse af lægemiddelinteraktioner
English: TURQUOISE-II - treatment-naïve or pegIFN + RBV-experienced with compensated cirrhosis
Danish: TURQUOISE II - behandlingsnaive eller pegIFN + RBV-erfarne med kompenseret cirrose
English: Frequency dasabuvir and ombitasvir/paritaprevir/ritonavir + ribavirin* N = 2,044
Danish: Dasabuvir og ombitasvir/paritaprevir/ritonavir + ribavirin* N = 2.044
English: The impact of prior dasabuvir, ombitasvir, or paritaprevir treatment experience on the efficacy of other NS5A inhibitors, NS3/4A protease inhibitors, or NS5B inhibitors has not been studied.
Danish: Det er ikke undersøgt, hvilken betydning tidligere dasabuvir-, ombitasvir- eller paritaprevir-behandling har for effekten af andre NS5A-hæmmere, NS3/4Aproteasehæmmere eller NS5B-hæmmere.
English: How long to take Exviera for
Danish: Så længe skal du tage Exviera
English: This is because serious or lifethreatening effects can occur when Exviera and ombitasvir/paritaprevir/ritonavir are taken with these medicines.
Danish: • hvis du tager et eller flere af de lægemidler, der er angivet i nedenstående tabel, da der kan opstå alvorlige eller livstruende virkninger, hvis Exviera og ombitasvir/paritaprevir/ritonavir tages sammen med disse lægemidler.
English: Common: may affect up to 1 in 10 people
Danish: Almindelige bivirkninger: forekommer hos op til 1 ud af 10 behandlede
English: Treatment outcome dasabuvir and ombitasvir/paritaprevir/ritonavir with RBV for 12 weeks n/N % 95% CI
Danish: Dasabuvir og ombitasvir/paritaprevir/ritonavir med RBV i 12 uger n/N % 95 %-KI
English: Hydrocodone (as given in a fixed-dose hydrocodone /paracetamol
Danish: Klinisk kommentar givet som fast doseret hydrokodon/p aracetamol)
English: Expected: ↓ dasabuvir ↓ombitasvir ↓ paritaprevir
Danish: Forventet: ↓ dasabuvir ↓ombitasvir ↓ paritaprevir
English: Tacrolimus whole blood concentrations should be monitored upon initiation and throughout coadministration with dasabuvir and ombitasvir/paritaprevir/ ritonavir and the dose and/or dosing frequency should be adjusted as needed.
Danish: Koncentrationen af tacrolimus i helblod bør overvåges ved start og under samtidig administration med dasabuvir og ombitasvir/paritaprevir/ri tonavir, og dosis og/eller doseringshyppighed bør justeres efter behov.
English: SVR12 for genotype 1-infected peginterferon+ribavirin-experienced subjects in SAPPHIRE-II
Danish: SVR12 for peginterferon/ribavirin-erfarne genotype 1-smittede forsøgspersoner i SAPPHIRE II
English: Mechanism: CYP3A4/CY P2C8 induction by rifampicin.
Danish: Mekanisme: Rifampicins inducerende virkning på CYP3A4/CY P2C8.
English: Sirolimus 2 mg was dosed alone, 0.5 mg administered with dasabuvir + ombitasvir/paritaprevir/ritonavir.
Danish: Sirolimus 2 mg blev doseret alene, 0,5 mg administreret med dasabuvir og ombitasvir/paritaprevir/ritonavir.
English: Tacrolimus or sirolimus whole blood concentrations should be monitored upon initiation and throughout co-administration with dasabuvir and ombitasvir/paritaprevir/ritonavir and the dose and/or dosing frequency should be adjusted as needed.
Danish: Koncentrationen af tacrolimus eller sirolimus i helblod bør overvåges ved initiering og under samtidig administration med dasabuvir og ombitasvir/paritaprevir/ritonavir og dosis og/eller doseringshyppighed bør justeres efter behov.
English: In Part 2, subjects with HCV GT1 received dasabuvir and ombitasvir/paritaprevir/ritonavir with or without ribavirin for 12 or 24 weeks.
Danish: I del 2 blev alle forsøgspersoner med HCV GT1 behandlet med dasabuvir og ombitasvir/paritaprevir/ritonavir med eller uden ribavirin i 12 eller 24 uger.
English: Darunavir combined with ombitasvir/paritaprevir/ ritonavir + dasabuvir is not recommended in patients with extensive PI resistance.
Danish: Darunavir sammen med ombitasvir/paritatprevir/ ritonavir og dasabuvir frarådes hos patienter med udtalt PI-resistens.
English: This is due to liver function changes during treatment with dasabuvir + ombitasvir/paritaprevir/ ritonavir
Danish: Det skyldes at leverfunktionen ændres under behandling med dasabuvir + ombitasvir/paritaprevir/ri tonavir
English: ALT elevations
Danish: Forhøjet ALAT
English: 250 mg single dose
Danish: 250 mg enkelt dosis
English: Enzalutamid e
Danish: Enzalutamid
English: 5 mg once daily
Danish: 5 mg én gang dagligt
English: GARNET - Genotype 1b, Treatment-Naïve without cirrhosis.
Danish: GARNET - genotype 1b, behandlingsnaive uden cirrose
English: See additional information on specific hormonal contraceptives in sections 4.3 and 4.4.
Danish: Læs mere om specifikke hormonale præventionsmidler i pkt.
English: Ciclosporin 100 mg dosed alone and 30 mg administered with dasabuvir + ombitasvir/paritaprevir/ritonavir.
Danish: Ciclosporin 100 mg administreret alene og ciclosporin 30 mg administreret sammen med dasabuvir + ombitasvir/paritaprevir/ritonavir.
English: Genotype 1a, without cirrhosis dasabuvir + ombitasvir/paritaprevir/ritonavir + ribavirin*
Danish: Genotype 1a, uden cirrose dasabuvir + ombitasvir/paritaprevir/ritonavir + ribavirin*
English: Coadministration with ethinyloestradiol may lead to increased risk of ALT elevations (see sections 4.3 and 4.4).
Danish: Samtidig administration af ethinyløstradiol kan medføre øget risiko for forhøjet ALAT (se pkt.
English: ↑ dabigatran etexilate dasabuvir + ombitasvir/paritaprevir/ ritonavir may increase the plasma concentrations of dabigatran etexilate.
Danish: Dasabuvir + ombitasvir/paritaprevir/ri tonavir kan øge plasmaconcentrationen af dabigatraetexilat.
English: Apalutamide, enzalutamide for prostate cancer ethinyloestradiol containing medicines such as those contained in most contraceptive pills and vaginal rings used for contraception for contraception gemfibrozil to lower cholesterol and other fats in the blood mitotane for some tumours of the adrenal glands rifampicin for bacterial infections
Danish: Lægemidlet tages/gives carbamazepin, phenytoin, phenobarbital mod epilepsi efavirenz, etravirin, nevirapin mod hiv-infektion apalutamid, enzalutamid mod prostatakræft ethinyløstradiol-holdige lægemidler som f.eks. de fleste p-piller og p-ringe som prævention gemfibrozil mod forhøjet forekomst af kolesterol og andre fedtstoffer i blodet mitotan mod nogle ondartede svulster i binyrerne rifampicin mod bakterieinfektioner prikbladet perikon (hypericum perforatum)
English: PEARL-III - genotype 1b, treatment-naïve, without cirrhosis Design:
Danish: PEARL III - genotype 1b, behandlingsnaive uden cirrose Design:
English: Paritaprevir treatment-emergent variants V36A/M, R155K or D168V were observed in NS3 in 47 subjects.
Danish: Følgende paritaprevir-behandlingsrelaterede varianter i NS3 blev observeret hos 47 forsøgspersoner: V36A/M, R155K eller D168V.
English: 5 days after completion of dasabuvir + ombitasvir/paritaprevir/ ritonavir treatment, the sirolimus dose and dosing frequency prior to receiving dasabuvir ombitasvir/paritaprevir/ ritonavir should be resumed, along with routine monitoring of sirolimus blood concentrations.
Danish: Sirolimus-dosis og doseringshyppighed, som før brug af dasabuvir + ombitasvir/paritaprevir/ri tonavir, kan sammen med rutinemæssig monitorering af sirolimus i blodet genoptages 5 dage efter afslutning af dasabuvir + ombitasvir/paritaprevir/ri tonavir behandling
English: Dasabuvir must always be administered together with ombitasvir/paritaprevir/ritonavir .
Danish: Dasabuvir skal altid administreres sammen med ombitasvir/paritaprevir/ritonavir.
English: ↑ fluvastatin ↑ pitavastatin ↔ dasabuvir ↔ ombitasvir ↔ paritaprevir
Danish: ↑ fluvastatin ↑ pitavastatin ↑ atorvastatin ↔ dasabuvir