FrancophonIA/ELRC3.0 huggingface dataset:
English: In patients whose vascular tone and renal function depend predominantly on the activity of the reninangiotensin-aldosterone system (e.g. patients with severe congestive heart failure or underlying renal disease, including renal artery stenosis), treatment with medicinal products that affect this system has been associated with acute hypotension, hyperazotaemia, oliguria, or rarely acute renal failure (see section 4.8).
Slovenian: Če sta žilni tonus in delovanje ledvic pretežno odvisna od delovanja renin-angiotenzinaldosteronskega sistema (npr. pri bolnikih s hudim kongestivnim srčnim popuščanjem ali ledvično boleznijo, tudi zožitvijo ledvične arterije), povezujejo zdravljenje z drugimi zdravili, katera delujejo na ta sistem, z akutno hipotenzijo, s hiperazotemijo, oligurijo in, redko, z akutno ledvično odpovedjo (glejte poglavje 4.8).
English: There is limited information available for telmisartan with regard to overdose in humans.
Slovenian: O prevelikem odmerjanju telmisartana pri ljudeh je malo podatkov.
English: Increased incidence of sepsis has been observed with telmisartan only, however can not be ruled out for PritorPlus.
Slovenian: Kljub temu, da so povečano pojavnost opazili pri samostojni uporabi telmisartana, je med jemanjem zdravila PritorPlus ni možno izključiti.
English: Based on the experience with the use of other medicinal products that blunt the renin-angiotensin system, concomitant use of the above medicinal products may lead to increases in serum potassium and is, therefore, not recommended (see section
Slovenian: Izkušnje z drugimi zdravili, ki zavirajo delovanje renin-angiotenzinskega sistema, kažejo, da lahko sočasno dajanje teh zdravil poveča raven kalija v serumu, in jih zato ne priporočamo (glejte poglavje 4.4).
English: Investigations Not known:
Slovenian: Preiskave Neznana:
English: When clinically appropriate, direct change from monotherapy to the fixed combination may be considered.
Slovenian: Kadar bolnikovo klinično stanje dopušča, se lahko odločimo za neposreden prehod z monoterapije na zdravljenje s fiksno kombinacijo.
English: Anorexia, appetite decreased, electrolyte imbalance, hypercholesterolaemia, hyperglycaemia, hypovolaemia.
Slovenian: hipomagneziemija hiperkalciemija hipokloremična alkaloza anoreksija, zmanjšan apetit, elektrolitsko neravnovesje, hiperholesterolemija, hiperglikemija, hipovolemija
English: PritorPlus fixed dose combination (40 mg telmisartan/12.5 mg hydrochlorothiazide and 80 mg telmisartan/12.5 mg hydrochlorothiazide) is indicated in adults whose blood pressure is not adequately controlled on telmisartan alone.
Slovenian: Zdravilo PritorPlus, fiksna kombinacija (40 mg telmisartana/12,5 mg hidroklorotiazida in 80 mg telmisartana/12,5 mg hidroklorotiazida), je indicirano za odrasle, pri katerih krvnega tlaka ne moremo ustrezno uravnati s samim telmisartanom.
English: - If you have had skin cancer or if you develop an unexpected skin lesion during the treatment.
Slovenian: Brez zdravljenja lahko pride do trajne okvare vida; - če ste imeli kožnega raka ali če se vam med zdravljenjem pojavijo nepričakovane kožne spremembe.
English: PritorPlus is a combination of an angiotensin II receptor antagonist, telmisartan, and a thiazide diuretic, hydrochlorothiazide.
Slovenian: Zdravilo PritorPlus je kombinacija antagonista receptorjev angiotenzina II telmisartana in tiazidnega diuretika hidroklorotiazida.
English: PritorPlus is used to treat high blood pressure (essential hypertension) in adults whose blood pressure is not controlled enough when telmisartan is used alone.
Slovenian: Zdravilo PritorPlus je namenjeno za zdravljenje visokega krvnega tlaka (esencialne hipertenzije) pri odraslih, pri katerih s samim telmisartanom krvnega tlaka ne moremo dovolj uravnati.
English: How to take PritorPlus
Slovenian: Kako jemati zdravilo PritorPlus
English: PritorPlus should be kept in the sealed blister due to the hygroscopic property of the tablets.
Slovenian: Zdravilo PritorPlus je treba shranjevati v zaprtem pretisnem omotu, ker so tablete higroskopične.
English: Hydrochlorothiazide is excreted in human milk in small amounts.
Slovenian: Majhna količina hidroklorotiazida se izloča v materino mleko.
English: Telmisartan does not accumulate significantly in plasma on repeated administration.
Slovenian: Telmisartan se po ponovnem dajanju v plazmi pomembneje ne kopiči.
English: In dogs renal tubular dilation and atrophy were observed.
Slovenian: Pri psih so zasledili razširitev ledvičnih tubulov in atrofijo.
English: 1: Based on post-marketing experience 2: For further description, please see sub-section “Description of selected adverse reactions”
Slovenian: 2: Za podrobnejši opis glejte podpoglavje »Opis izbranih neželenih učinkov«
English: MARKETING AUTHORISATION NUMBER(S) PritorPlus 40 mg/12.5 mg tablets EU/1/02/215/001-005, 011, 013
Slovenian: PritorPlus 40 mg/12,5 mg tablete EU/1/02/215/001-005, 011, 013
English: Thiazides should be used with caution in patients with impaired hepatic function (see section 4.4).
Slovenian: Tiazide moramo previdno dajati bolnikom z zmanjšanim delovanjem jeter (glejte poglavje 4.4).
English: Diarrhoea, dry mouth, flatulence Abdominal pain, constipation, dyspepsia, vomiting, gastritis
Slovenian: abdominalna bolečina, zaprtje, dispepsija, bruhanje, gastritis
English: Typical symptoms of fluid or electrolyte imbalance include dry mouth, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, nausea (feeling sick), vomiting, tired muscles, and an abnormally fast heart rate (faster than 100 beats per minute).
Slovenian: Značilni simptomi neravnovesja tekočine ali elektrolitov so suha usta, šibkost, letargija, dremavost, nemir, mišična bolečina ali krči, slabost (siljenje na bruhanje), bruhanje, utrujene mišice in nenormalno hitro bitje srca (več kot 100 utripov na minuto).
English: Each 40 mg/12.5 mg tablet contains 112 mg of lactose monohydrate and 169 mg sorbitol (E420).
Slovenian: Ena 40 mg/12,5 mg tableta vsebuje 112 mg laktoze monohidrata in 169 mg sorbitola (E420).
English: There is no experience regarding the administration of PritorPlus in patients with recent kidney transplantation.
Slovenian: Z uporabo zdravila PritorPlus pri bolnikih z nedavno presajeno ledvico ni izkušenj.
English: If these medicinal products are to be prescribed with the hydrochlorothiazide-telmisartan combination, monitoring of potassium plasma levels is advised.
Slovenian: Če moramo našteta zdravila predpisati hkrati s kombinacijo hidroklorotiazida in telmisartana, priporočamo spremljanje ravni kalija v plazmi.
English: Thiazide-induced hypokalaemia or hypomagnesaemia favours the onset of digitalis-induced arrhythmia (see section 4.4).
Slovenian: Hipokaliemija ali hipomagneziemija, ki jo povzročajo tiazidi, poveča možnost nastanka aritmije, inducirane z digitalisom (glejte poglavje 4.4).
English: Each tablet contains 99 mg of lactose monohydrate and 338 mg sorbitol (E420).
Slovenian: Ena tableta vsebuje 99 mg laktoze monohidrata in 338 mg sorbitola (E420).
English: Tachycardia, arrhythmias
Slovenian: tahikardija, aritmije
English: Haemoglobin decreased
Slovenian: znižan hemoglobin
English: Cytotoxic agents (e.g. cyclophosphamide, methotrexate)
Slovenian: Citotoksična zdravila (npr. ciklofosfamid, metotreksat)
English: Dosage adjustment of the antidiabetic medicinal products may be required (see section 4.4).
Slovenian: Včasih je treba prilagoditi odmerek antidiabetika (glejte poglavje 4.4).
English: There was a trend towards higher plasma concentrations of hydrochlorothiazide in female than in male subjects.
Slovenian: Tudi plazemske koncentracije hidroklorotiazida se pri ženskah nagibajo k nekoliko večjim vrednostim.
English: Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy and periodically thereafter.
Slovenian: Bolniki morajo biti ustrezno hidrirani na začetku sočasnega zdravljenja in v rednih razmikih med njim pa je treba presoditi tudi o spremljanju delovanja ledvic.
English: If you experience any of these you should tell your doctor.
Slovenian: Če opazite katerikoli pojav od naštetih, obvestite svojega zdravnika.
English: Slow heartbeat, dizziness, vomiting, reduced kidney function including kidney failure, have also been reported.
Slovenian: V poročilih navajajo še počasen srčni utrip, omotico, bruhanje in zmanjšano ledvično delovanje, tudi ledvično odpoved.
English: Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone-system (RAAS) through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4 and 5.1).
Slovenian: Podatki kliničnih preskušanj so pokazali, da je dvojna blokada sistema renin-angiotenzin-aldosteron (RAAS) s hkratno uporabo zaviralcev ACE, blokatorjev receptorjev angiotenzina II ali aliskirena povezana z večjo pogostnostjo neželenih učinkov, npr. hipotenzije, hiperkaliemije in zmanjšanega delovanja ledvic (vključno z akutno odpovedjo ledvic) kot uporaba enega samega zdravila,ki deluje na RAAS (glejte poglavja 4.3, 4.4. in 5.1).
English: What PritorPlus contains
Slovenian: Kaj vsebuje zdravilo PritorPlus
English: Previous preclinical safety studies performed with co-administration of telmisartan and hydrochlorothiazide in normotensive rats and dogs, in doses producing exposure comparable to that in the clinical therapeutic range, caused no additional findings not already observed with administration of either substance alone.
Slovenian: Predhodne predklinične raziskave o varnosti, v katerih so telmisartan in hidroklorotiazid sočasno dajali normotenzivnim podganam in psom, odmerki, ki so ustrezali tistim v kliničnem terapevtskem razponu, niso imeli učinkov, ki bi se razlikovali od onih, ki so znani za posamezni snovi.
English: In addition, there was a significantly higher incidence of hyperkalaemia, renal failure, hypotension and syncope in the combination arm.
Slovenian: Poleg tega je bila v skupini, ki je jemala kombinacijo zdravil, značilno večja pojavnost hiperkaliemije, ledvične odpovedi, hipotenzije in sinkope.
English: No statistically significant difference in the incidence of the primary composite endpoint (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for congestive heart failure) was found [15.7 % in the telmisartan and 17.0 % in the placebo groups with a hazard ratio of 0.92 (95 % CI 0.81 - 1.05, p = 0.22)].
Slovenian: Pri pojavnosti primarnega, sestavljenega opazovanega dogodka (kot so srčnožilna smrt, neusodni miokardni infarkt, neusodna možganska kap ali bolnišnično zdravljenje zaradi zastojnega srčnega popuščanja) med skupinama ni bilo statistično značilne razlike [15,7 % v skupini s telmisartanom in 17,0 % v skupini s placebom ob razmerju ogroženosti 0,92 (95-odstotni IZ 0,81 do 1,05, p = 0,22)].
English: Beta-blockers and diazoxide
Slovenian: Zaviralci adrenergičnih receptorjev beta in diazoksid
English: Co-administration of lithium and PritorPlus is not recommended (see section 4.4).
Slovenian: Sočasno dajanje litija in zdravila PritorPlus ne priporočamo (glejte poglavje 4.4).
English: Upper respiratory tract infection, urinary tract infection including cystitis
Slovenian: okužba zgornjih dihal, okužba sečil, tudi cistitis
English: • PritorPlus 40 mg/12.5 mg may be administered once daily in patients whose blood pressure is not adequately controlled by Pritor 40 mg
Slovenian: • Zdravilo PritorPlus 40 mg/12,5 mg lahko dajemo enkrat na dan bolnikom, pri katerih krvnega tlaka ne moremo ustrezno nadzorovati z zdravilom Pritor 40 mg
English: The degree to which hydrochlorothiazide is removed by haemodialysis has not been established.
Slovenian: Koliko hidroklorotiazida se odstrani s hemodializo, ni raziskano.
English: The overall incidence of adverse reactions reported with PritorPlus was comparable to those reported with telmisartan alone in randomised controlled trials involving 1471 patients randomised to receive telmisartan plus hydrochlorothiazide (835) or telmisartan alone (636).
Slovenian: V kliničnih preskušanjih je sodelovalo 1471 bolnikov, ki so bili naključno razvrščeni v skupini, od katerih je ena prejemala telmisartan in hidroklorotiazid (835), druga pa samo telmisartan (636).
English: Presumably through blockade of the reninangiotensin-aldosterone system, co-administration of telmisartan tends to reverse the potassium loss associated with these diuretics.
Slovenian: Sočasno dajanje telmisartana domnevno deluje zaradi blokade renin-angiotenzinaldosteronskega sistema, reverzibilno na izgubo kalija, do katere prihaja pri teh diuretikih.
English: Visual disturbance, vision blurred
Slovenian: motnje vida, meglen vid
English: Telmisartan is not removed from blood by haemodialysis.
Slovenian: Telmisartan se s hemodializo ne odstrani.
English: Endocrine disorders Not known:
Slovenian: Bolezni endokrinega sistema Neznana:
English: Based on available data from epidemiological studies, cumulative dose-dependent association between HCTZ and NMSC has been observed.
Slovenian: Na podlagi obstoječih podatkov epidemioloških študij so ugotovili, da obstaja razmerje med kumulativnim odmerkom hidroklorotiazida in nemelanomskim kožnim rakom.
English: The hazard ratio for telmisartan vs. ramipril was 1.01 (97.5 % CI 0.931.10, p (non-inferiority) = 0.0019 at a margin of 1.13).
Slovenian: Pri zdravljenju s telmisartanom je bilo razmerje ogroženosti v primerjavi z ramiprilom 1,01 (97,5-odstotni IZ 0,93 do 1,10, p (enakovrednost) = 0,0019 pri mejni vrednosti 1,13).
English: Exposure to angiotensin II receptor antagonist therapy during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (See section 5.3).
Slovenian: Znano je, da izpostavljenost antagonistom angiotenzina II v drugem in tretjem trimesečju nosečnosti lahko povzroči fetotoksične učinke pri človeku (zmanjšano delovanje ledvic, oligohidramnij, zapoznela zakostenitev lobanje) in toksične učinke pri novorojenčku (ledvična odpoved, hipotenzija, hiperkaliemija) (glejte poglavje 5.3).
English: Warning signs of fluid or electrolyte imbalance are dryness of mouth, thirst, asthenia, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea or vomiting (see section 4.8).
Slovenian: Opozorilni znaki, ki kažejo na motnje ravnovesja tekočin ali elektrolitov, so suha usta, žeja, astenija, brezvoljnost, dremavica, nemir, mišična bolečina ali krči, mišična utrujenost, hipotenzija, oligurija, tahikardija in prebavne motnje, npr. slabost ali bruhanje (glejte poglavje 4.8).
English: Eczema, drug eruption, toxic skin eruption Musculoskeletal, connective tissue and bone disorders Rare:
Slovenian: ekcem, medikamentni izpuščaj, toksični kožni izpuščaj Bolezni mišično-skeletega sistema, vezivnega tkiva in kosti Redki:
English: Only minute amounts were found in urine.
Slovenian: V seču so izmerili le neznatno količino.
English: Vasculitis necrotizing
Slovenian: nekrotizirajoči vaskulitis
English: (It is also better to avoid PritorPlus in early pregnancy
Slovenian: • če ste noseči več kot 3 mesece (zdravilu PritorPlus se je bolje izogibati tudi v zgodnji nosečnosti
English: In a double-blind controlled clinical trial (n=687 patients evaluated for efficacy) in non-responders to the 80 mg/12.5 mg combination, an incremental blood pressure lowering effect of the 80 mg/25 mg combination compared to continued treatment with the 80 mg/12.5 mg combination of 2.7/1.6 mm Hg (SBP/DBP) was demonstrated (difference in adjusted mean changes from baseline).
Slovenian: V dvojno slepi, nadzorovani klinični raziskavi (n = 687 bolnikov, pri katerih so ocenili učinkovitost) pri bolnikih, ki se niso odzivali na zdravljenje s kombinacijo 80 mg/12,5 mg, je kombinacija 80 mg/25 mg v primerjavi s stalnim zdravljenjem s kombinacijo 80 mg/12,5 dodatno znižala krvni tlak za 2,7/1,6 mm Hg (SKT/DKT) (razlika v prilagojenih srednjih spremembah glede na izhodiščno vrednost).
English: Renal excretion does not contribute to the clearance of telmisartan.
Slovenian: Izločanje skozi ledvice ne poveča telmisartanovega očistka.
English: Hepatic impairment
Slovenian: glavobol omotica
English: These could be symptoms of an increase of pressure in your eye and can happen within hours to weeks of taking PritorPlus.
Slovenian: Oba sta lahko tudi simptoma zvišanega očesnega tlaka, ki se pojavita nekaj ur do nekaj tednov po začetku jemanja zdravila PritorPlus.
English: As for any patient receiving diuretic therapy, periodic determination of serum electrolytes should be performed at appropriate intervals.
Slovenian: Enako kot pri vseh bolnikih, ki se zdravijo z diuretiki, so potrebni periodični kontrolni pregledi ravni elektrolitov v serumu.
English: There was evidence for a benefit of telmisartan compared to placebo in the pre-specified secondary composite endpoint of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke [0.87 (95 % CI 0.76 - 1.00, p = 0.048)].
Slovenian: Podatki dokazujejo korist zdravljenja s telmisartanom v primerjavi s placebom na podlagi njegovega učinka na vnaprej opredeljen sekundarni, sestavljeni opazovani dogodek, ki je zajemal srčnožilno smrt, neusodni miokardni infarkt in neusodno možgansko kap [0,87 (95-odstotni IZ 0,76 do 1,00, p = 0,048)].
English: Each 80 mg/12.5 mg tablet contains 112 mg of lactose monohydrate and 338 mg sorbitol (E420).
Slovenian: Ena 80 mg/12,5 mg tableta vsebuje 112 mg laktoze monohidrata in 338 mg sorbitola (E420).
English: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Slovenian: V prisotnosti anionskih izmenjalnih smol je motena absorpcija hidroklorotiazida.
English: In preclinical safety studies performed with co-administration of telmisartan and hydrochlorothiazide in normotensive rats and dogs, doses producing exposure comparable to that in the clinical therapeutic range caused no additional findings not already observed with administration of either substance alone.
Slovenian: Predklinične raziskave o varnosti, v katerih so telmisartan in hidroklorotiazid sočasno dajali normotenzivnim podganam in psom, odmerki, ki so ustrezali tistim v kliničnem terapevtskem razponu, niso imeli učinkov, ki bi se razlikovali od onih, ki so znani za posamezni snovi.
English: • PritorPlus 80 mg/12.5 mg may be administered once daily in patients whose blood pressure is not adequately controlled by Pritor 80 mg
Slovenian: • Zdravilo PritorPlus 80 mg/12,5 mg lahko dajemo enkrat na dan bolnikom, pri katerih krvnega tlaka ne moremo ustrezno nadzorovati z zdravilom Pritor 80 mg
English: Telmisartan showed no evidence of mutagenicity and relevant clastogenic activity in in vitro studies and no evidence of carcinogenicity in rats and mice.
Slovenian: Telmisartan v in vitro študijah pri podganah in miših ni imel mutagenih učinkov ali pomembnejšega klastogenega delovanja in ni deloval kancerogeno.
English: If this combination proves essential, careful monitoring of serum lithium level is recommended during concomitant use.
Slovenian: Če je kombinirano zdravljenje nujno potrebno, je priporočljivo pazljivo spremljanje serumske ravni litija.
English: Pack sizes: - Blister with 14, 28, 30, 56, 90, or 98 tablets or - Perforated unit dose blisters with 28 x 1 tablets.
Slovenian: Velikost pakiranja: - pretisni omot po 14, 28, 30, 56, 90 ali 98 tablet ali - perforirani pretisni omoti za enkratni odmerek po 28 x 1 tableto.
English: In patients with mild to moderate hepatic impairment the posology should not exceed PritorPlus 40 mg/12.5 mg once daily.
Slovenian: Odmerek za bolnike z blago do zmerno zmanjšanim jetrnim delovanjem ne sme prekoračiti odmerka zdravila PritorPlus 40 mg/12,5 mg 1-krat na dan.
English: Pancreatitis, stomach discomfort
Slovenian: navzea pankreatitis, želodčne težave
English: Individual dose titration with each of the two components is recommended before changing to the fixed dose combination.
Slovenian: Pred prehodom na zdravljenje s fiksno kombinacijo je priporočljivo, da najprej individualno prilagodimo odmerka posameznih sestavin kombinacije.
English: Blood and lymphatic system disorders Uncommon:
Slovenian: Bolezni krvi in limfatičnega sistema Redki:
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Unit dose blister (28x1 tablets pack) or any non 7 count blister
Slovenian: Perforiran pretisni omot za enkratni odmerek (28 x 1 tableta) ali vsi tisti pretisni omoti, ki ne vsebujejo po 7 tablet
English: Hydrochlorothiazide exhibits linear pharmacokinetics.
Slovenian: Hidroklorotiazid kaže linerano farmakinetiko.
English: EU/1/02/215/015 14 tablets EU/1/02/215/016 28 tablets EU/1/02/215/017 28 x 1 tablets EU/1/02/215/018 30 tablets EU/1/02/215/019 56 tablets EU/1/02/215/020 90 tablets EU/1/02/215/021 98 tablets
Slovenian: EU/1/02/215/015 14 tablet EU/1/02/215/016 28 tablet EU/1/02/215/017 28 x 1 tableta EU/1/02/215/018 30 tablet EU/1/02/215/019 56 tablet EU/1/02/215/020 90 tablet EU/1/02/215/021 98 tablet
English: Coadministration of thiazide may increase the incidence of hypersensitivity reactions of allopurinol.
Slovenian: Sočasno dajanje tiazida lahko poveča pogostnost preobčutljivostnih reakcij na alopurinol.
English: Hypokalaemia Hyperuricaemia, hyponatraemia
Slovenian: hiperurikemija, hiponatriemija
English: Common side effects (may affect up to 1 in 10 people): Feeling sick (nausea), low blood magnesium level.
Slovenian: Pogosti neželeni učinki (lahko se pojavijo pri največ 1 od 10 bolnikov): slabost (navzea), nizka raven magnezija v krvi.
English: Thiazides may decrease urinary calcium excretion and cause an intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism.
Slovenian: Tiazidi lahko zmanjšajo izločanje kalcija s sečem in občasno blago povečajo njegovo raven v serumu, kadar ni znanih motenj njegove presnove.
English: Reduction in blood platelets, which increases risk of bleeding or bruising (small purple-red marks in skin or other tissue caused by bleeding), high blood calcium level, headache.
Slovenian: Redki neželeni učinki (lahko se pojavijo pri največ 1 od 1.000 bolnikov): zmanjšanje števila trombocitov, kar poveča tveganje za krvavitve ali nastanek modric (majhne vijoličnordeče lise na koži ali drugih tkivih, ki jih povzroča krvavitev), visoka raven kalcija v krvi, glavobol.
English: Adverse reactions reported with one of the individual components may be potential adverse reactions with PritorPlus, even if not observed in clinical trials with this product.
Slovenian: Neželeni učinki, o katerih so poročali za eno od posameznih sestavin, se lahko pojavijo tudi pri zdravilu PritorPlus, četudi jih v kliničnem preskušanju tega zdravila niso zasledili.
English: In a pooled analysis of two similar 8 week double-blind placebo-controlled clinical trials vs. valsartan/hydrochlorothiazide 160 mg/25 mg (n=2121 patients evaluated for efficacy) a significantly greater blood pressure lowering effect of 2.2/1.2 mm Hg (SBP/DBP) was demonstrated (difference in adjusted mean changes from baseline, respectively) in favour of telmisartan/hydrochlorothiazide 80 mg/25 mg combination.
Slovenian: V analizi združenih podatkov iz dveh podobnih 8-tedenskih, dvojno slepih, s placebom nadzorovanih kliničnih raziskav, v katerih je bilo primerjano zdravilo kombinacija valsartan/hidroklorotiazid 160 mg/25 mg (n = 2121 bolnikov, pri katerih so ocenili učinkovitost), je bilo znižanje krvnega tlaka pri kombinaciji telmisartan/hidroklorotiazid 80 mg/25 mg značilno večje, in sicer za 2,2/1,2 mm Hg (SKT/DKT) (razlika v prilagojenih srednjih spremembah glede na izhodiščno vrednost).
English: PritorPlus is also available at the dose strengths 40 mg/12.5 mg and 80 mg/12.5 mg Renal impairment
Slovenian: Zdravilo PritorPlus je na voljo tudi v jakosti 40 mg/12,5 mg in 80 mg/12,5 mg. Ledvična okvara
English: How to store PritorPlus
Slovenian: Shranjevanje zdravila PritorPlus