FrancophonIA/ELRC3.0 huggingface dataset:
English: Synjardy can also be combined with other medicines for the treatment of diabetes.
Slovenian: Zdravilo Synjardy se lahko uporablja tudi v kombinaciji z drugimi zdravili za zdravljenje sladkorne bolezni.
English: 2 hour post-prandial glucose
Slovenian: Vrednost glukoze 2 uri po jedi
English: No Met
Slovenian: Brez Met
English: Hypoglycaemia has not been seen with metformin doses of up to 85 g, although lactic acidosis has occurred in such circumstances.
Slovenian: Pri odmerkih metformina do 85 g niso zasledili hipoglikemije, vendar se je pri takih primerih pojavila laktacidoza.
English: • Disease which may cause tissue hypoxia (especially acute disease, or worsening of chronic disease) such as: decompensated heart failure, respiratory failure, recent myocardial infarction,
Slovenian: • Bolezni, ki lahko povzročijo tkivno hipoksijo (predvsem akutne bolezni ali poslabšanje kroničnih bolezni), kot so: dekompenzirano srčno popuščanje, odpoved dihal, nedavni miokardni infarkt, šok.
English: Metformin increases the transport capacity of all types of membrane glucose transporters (GLUTs) known to date.
Slovenian: Metformin poveča sposobnost prenosa vseh doslej znanih membranskih prenašalcev glukoze (GLUT, glucose transporter).
English: No interaction studies have been performed for Synjardy.
Slovenian: Študij medsebojnega delovanja za zdravilo Synjardy niso izvedli.
English: The population pharmacokinetic analysis showed that the apparent oral clearance of empagliflozin decreased with a decrease in creatinine clearance leading to an increase in drug exposure.
Slovenian: Populacijska farmakokinetična analiza je pokazala, da se je navidezni peroralni očistek empagliflozina zmanjšal z zmanjšanjem kreatininskega očistka, kar je povzročilo večjo izpostavljenost zdravilu.
English: Therefore, caution should be exercised in patients for whom a empagliflozin-induced drop in blood pressure could pose a risk, such as patients with known cardiovascular disease, patients on anti-hypertensive therapy with a history of hypotension or patients aged 75 years and older.
Slovenian: Zato je potrebna previdnost pri bolnikih, pri katerih lahko znižanje krvnega tlaka, ki ga povzroči empagliflozin, predstavlja tveganje, kot so bolniki z znano boleznijo srca in ožilja, bolniki s hipotenzijo v anamnezi, ki se zdravijo z antihipertenzivi; ali bolniki, stari 75 let ali več.
English: Thereafter, eGFR was maintained during continued treatment.
Slovenian: V nadaljevanju zdravljenja se je vrednost eGFR ohranila.
English: For metformin, AUC decreased by 12% and Cmax decreased by 26% compared to fasting conditions.
Slovenian: Za metformin se je vrednost AUC zmanjšala za 12 %, vrednost Cmax pa za 26 % v primerjavi s stanjem na tešče.
English: The following statements reflect the pharmacokinetic properties of the individual active substances of Synjardy.
Slovenian: Spodnje trditve temeljijo na farmakokinetičnih lastnostih posameznih zdravilnih učinkovin zdravila Synjardy.
English: Taking this medicine in combination with medicines called sulphonylureas or with insulin can cause blood sugar levels to drop too low (hypoglycaemia), which may cause symptoms such as shaking, sweating and change in vision, and may affect your ability to drive and use machines.
Slovenian: Jemanje tega zdravila skupaj z zdravili, imenovanimi sulfonilsečnine, ali z insulinom lahko povzroči znižanje ravni krvnega sladkorja (hipoglikemijo), ki lahko povzroči simptome, kot so tresenje, znojenje in spremembe vida, in lahko vpliva na vašo sposobnost vožnje in upravljanja s stroji.
English: The mean age was 63 years, the mean HbA1c was 8.1%, and 71.5% were male.
Slovenian: Povprečna starost bolnikov je bila 63 let, povprečna vrednost HbA1c 8,1 %, 71,5 % bolnikov je bilo moških.
English: Your doctor may prescribe Synjardy together with another diabetes medicine.
Slovenian: Zdravnik vam lahko predpiše zdravilo Synjardy skupaj z drugim antidiabetičnim zdravilom.
English: In patients with type 2 diabetes, urinary glucose excretion increased immediately following the first dose of empagliflozin and is continuous over the 24 hour dosing interval.
Slovenian: Pri bolnikih s sladkorno boleznijo tipa 2 se je izločanje glukoze z urinom povečalo takoj po prvem odmerku empagliflozina in je ostalo v 24-urnem intervalu odmerjanja stalno.
English: Drug-drug interactions involving the major CYP450 and UGT isoforms with empagliflozin and concomitantly administered substrates of these enzymes are therefore considered unlikely.
Slovenian: Zato medsebojno delovanje, pri katerem sodelujejo glavne izooblike CYP450 in UGT, med empagliflozinom in sočasno uporabljenimi substrati teh encimov ni verjetno.
English: The prospective randomised (UKPDS) study has established the long-term benefit of intensive blood glucose control in type 2 diabetes.
Slovenian: Metformin V prospektivni randomizirani študiji (UKDPS) je bila dokazana dolgoročna korist intenzivnega urejanja glukoze v krvi pri sladkorni bolezni tipa 2.
English: Based on the mode of action of SGLT2 inhibitors, osmotic diuresis accompanying therapeutic glucosuria may lead to a modest decrease in blood pressure (see section 5.1).
Slovenian: Na podlagi načina delovanja zaviralcev SGLT2 lahko osmotska diureza, ki spremlja terapevtsko glukozurijo, povzroči zmerno znižanje krvnega tlaka (glejte poglavje 5.1).
English: Other side effects while taking Synjardy: Very common
Slovenian: Drugi neželeni učinki, ki se lahko pojavijo med jemanjem zdravila Synjardy: Zelo pogosti:
English: • Take the tablets with meals to lower your chance of an upset stomach.
Slovenian: • Tablete zaužijte ob jedi, da zmanjšate možnost pojava želodčnih težav.
English: Lactic acidosis Vitamin B12 deficiency
Slovenian: žeja diabetična ketoacidoza laktacidoza pomanjkanje vitamina B12
English: • blood tests may show changes in blood fat (cholesterol) levels in your blood
Slovenian: • krvni testi lahko pokažejo spremembe ravni maščob v krvi (holesterol).
English: Synjardy should be taken twice daily with meals to reduce the gastrointestinal adverse reactions associated with metformin.
Slovenian: Zdravilo Synjardy je treba jemati dvakrat dnevno med jedjo, da bi zmanjšali z metforminom povezane neželene učinke na prebavila.
English: Pharmacotherapeutic group: Drugs used in diabetes, combinations of oral blood glucose lowering drugs, ATC code: A10BD20
Slovenian: Farmakoterapevtska skupina: zdravila za zdravljenje diabetesa, kombinacije peroralnih antidiabetikov, oznaka ATC: A10BD20
English: C]-empagliflozin solution to healthy volunteers, approximately 96% of the drug-related radioactivity was eliminated in faeces (41%) or urine (54%).
Slovenian: Po peroralnem zaužitju raztopine C]-empagliflozina se je pri zdravih prostovoljcih približno 96 % radioaktivnosti, povezane z zdravilom, izločilo v blato (41 %) ali urin (54 %).
English: For patients with acute and unstable heart failure, Synjardy is contraindicated due to the metformin component (see section 4.3).
Slovenian: Pri bolnikih z akutnim in nestabilnim srčnim popuščanjem je zdravilo Synjardy kontraindicirano, ker vsebuje metformin (glejte poglavje 4.3)
English: Empagliflozin is a substrate of the human uptake transporters OAT3, OATP1B1, and OATP1B3, but not OAT1 and OCT2.
Slovenian: Empagliflozin je substrat humanih privzemnih prenašalcev OAT3, OATP1B1 in OATP1B3, ne pa tudi OAT1 in OCT2.
English: What you need to know before you take Synjardy
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Synjardy
English: Stop taking Synjardy for a short time if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal.
Slovenian: Za kratek čas prenehajte jemati zdravilo Synjardy, če imate stanje, ki je lahko povezano z dehidracijo (znatna izguba telesnih tekočin), kot je hudo bruhanje, driska, zvišana telesna temperatura, izpostavljenost vročini ali če pijete manj tekočine, kot običajno.
English: Your doctor may decide to temporarily or permanently stop your treatment with Synjardy.
Slovenian: Zdravnik se lahko odloči za začasno ali dokončno prekinitev zdravljenja z zdravilom Synjardy.
English: If you need to have an injection of a contrast medium that contains iodine into your bloodstream, for example in the context of an X-ray or scan, you must stop taking Synjardy before or at the time of the injection.
Slovenian: Če vam bodo v krvni obtok injicirali kontrastno sredstvo, ki vsebuje jod, na primer zaradi rentgenskega ali drugega slikanja, morate pred časom injiciranja ali v tem času prenehati z jemanjem zdravila Synjardy.
English: At the recommended metformin doses and dosing schedules, steady-state plasma concentrations are reached within 24 to 48 hours and are generally less than 1 microgram/ml.
Slovenian: Pri uporabi priporočenih odmerkov in shem odmerjanja doseže metformin koncentracijo v stanju dinamičnega ravnovesja v plazmi v 24 do 48 urah, in je na splošno manjša od 1 mikrograma/ml.
English: Empagliflozin and metformin
Slovenian: Empagliflozin in metformin
English: • blood tests may show changes related to kidney function (creatinine or urea)
Slovenian: • krvni testi lahko pokažejo spremembe, povezane z delovanjem ledvic (kreatinin ali sečnina);
English: Table 2: Tabulated list of adverse reactions (MedDRA) from placebo-controlled studies and from post-marketing experience
Slovenian: Preglednica 2: Tabelarični pregled neželenih učinkov (MedDRA), o katerih so poročali pri s placebom nadzorovanih študijah in na osnovi izkušenj v obdobju trženja
English: Synjardy with alcohol
Slovenian: Zdravilo Synjardy skupaj z alkoholom
English: For patients insufficiently controlled on metformin (either alone or in combination with other medicinal products for the treatment of diabetes)
Slovenian: Pri bolnikih z nezadostno urejeno boleznijo pri jemanju metformina (v monoterapiji ali v kombinaciji z drugimi zdravili za zdravljenje sladkorne bolezni)
English: Lactic acidosis, seen very rarely (may affect up to 1 in 10,000 people) Synjardy may cause a very rare but very serious side effect called lactic acidosis (see section ‘Warnings and precautions').
Slovenian: Laktacidoza, zelo redka (pojavi se lahko pri največ 1 od 10.000 bolnikov) Zdravilo Synjardy lahko povzroči zelo redek, a zelo resen neželeni učinek, imenovan laktacidoza (glejte poglavje "Opozorila in previdnostni ukrepi").
English: At 78 weeks, the decrease in HbA1c and insulin sparing effect of empagliflozin was maintained.
Slovenian: V 78. tednu se je zmanjšanje vrednosti HbA1c in varčevanje z insulinom zaradi empagliflozina ohranilo.
English: Compared to linagliptin 5 mg, both doses of empagliflozin plus linagliptin 5 mg provided statistically significant reductions in FPG and blood pressure.
Slovenian: V primerjavi z linagliptinom 5 mg sta oba odmerka empagliflozina z linagliptinom 5 mg nadalje povzročila statistično značilno zmanjšanje vrednosti FPG in krvnega tlaka.
English: The mode of action for these tumours is dependent on the natural predisposition of the male mouse to renal pathology and a metabolic pathway not reflective of humans.
Slovenian: Mehanizem delovanja pri teh tumorjih je odvisen od naravne nagnjenosti mišjih samcev k boleznim ledvic in presnovne poti, ki pri človeku ni prisotna.
English: • if you have a severe infection such as an infection affecting your lung or bronchial system or your kidney.
Slovenian: • če imate hudo okužbo, kot je okužba, ki prizadene pljuča, bronhije ali ledvice.
English: Your doctor may ask you to stop taking Synjardy until you have recovered.
Slovenian: Vaš zdravnik vam bo morda naročil, da zdravilo Synjardy prenehate jemati, dokler ne okrevate.
English: Most toxicity was consistent with secondary pharmacology related to urinary glucose loss and electrolyte imbalances including decreased body weight and body fat, increased food consumption, diarrhoea, dehydration, decreased serum glucose and increases in other serum parameters reflective of increased protein metabolism and gluconeogenesis, urinary changes such as polyuria and glucosuria, and microscopic changes including mineralisation in kidney and some soft and vascular tissues.
Slovenian: Toksičnost je bila povečini skladna s sekundarno farmakologijo, povezano z izgubo glukoze z urinom, in neravnovesjem elektrolitov, vključno z zmanjšanjem telesne mase in telesne maščobe, povečanim uživanjem hrane, drisko, dehidracijo, zmanjšanjem glukoze v serumu in povečanjem drugih serumskih parametrov, ki so posledica večje presnove beljakovin in glukoneogeneze, spremembami urina, kot so poliurija in glukozurija, in mikroskopskimi spremembami, vključno z mineralizacijo v ledvicah ter delno v mehkem in žilnem tkivu.
English: These symptoms could be a sign of “diabetic ketoacidosis”a rare, but serious, sometines life-threatening problem you can get with diabetes because of increased levels of “ketone bodies” in your urine or blood, seen in tests.
Slovenian: Ti simptomi so lahko znak “diabetične ketoacidoze”, redke, vendar resne in včasih življenjsko nevarne težave, ki se lahko pojavi pri sladkorni bolezni zaradi povišanih ravni “ketonskih teles” v urinu ali krvi, kar je razvidno iz laboratorijskih preiskav.
English: Body Weight (kg) at week 52
Slovenian: Telesna masa (kg) v 52. tednu
English: • if you have lost a lot of water from your body (dehydration), e.g. due to long-lasting or severe diarrhoea, or if you have vomited several times in a row.
Slovenian: • če ste izgubili veliko vode (dehidracija), npr. zaradi dolgotrajne ali hude driske ali večkratnega zaporednega bruhanja.
English: • shaking, sweating, feeling very anxious or confused, fast heart beat
Slovenian: • tresenje, znojenje, občutek tesnobe ali zmedenosti, hiter srčni utrip;
English: The inter-subject and residual variabilities for empagliflozin oral clearance were 39.1% and 35.8%, respectively.
Slovenian: Za peroralni očistek je bila variabilnost empagliflozina med posamezniki 39,1 %, rezidualna variabilnost pa 35,8 %.
English: • if you have severely reduced kidney function;
Slovenian: • če imate hudo oslabljeno delovanje ledvic,
English: The amount of glucose removed by the kidney through this glucuretic mechanism is dependent on blood glucose concentration and GFR.
Slovenian: Količina glukoze, ki jo ledvice izločijo s pomočjo tega glukuretičnega mehanizma, je odvisna od koncentracije glukoze v krvi in hitrosti glomerulne filtracije (GFR).
English: No Met mg mg
Slovenian: + Met mg mg
English: After oral administration, empagliflozin was rapidly absorbed with peak plasma concentrations occurring at a median tmax of 1.5 hours post-dose.
Slovenian: Po peroralnem jemanju se je empagliflozin hitro absorbiral in dosegel največjo koncentracijo v plazmi z medianim tmax 1,5 ure po odmerku.
English: Similar results were obtained when Synjardy (empagliflozin/metformin) combination tablets were administered with high-fat and high calorie meal.
Slovenian: Rezultati so bili podobni pri dajanju kombiniranih tablet Synjardy (empagliflozin/metmorfin) sočasno z obrokom z visoko vsebnostjo maščob in kalorij.
English: • medicines used to treat pain and inflammation (NSAID and COX-2-inhibitors, such as ibuprofen and celecoxib).
Slovenian: • zdravila za zdravljenje bolečine in vnetja (nesteroidna protivnetna zdravila in ali zaviralci COX2, kot sta ibuprofen in celekoksib),
English: • Metformin works in a different way to lower blood sugar levels, mainly by blocking glucose production in the liver.
Slovenian: • Metformin ima drugačen mehanizem zniževanja ravni krvnega sladkorja, ki pretežno vključuje zaviranje nastajanja glukoze v jetrih.
English: Synjardy may cause a very rare, but very serious side effect called lactic acidosis, particularly if your kidneys are not working properly.
Slovenian: Zdravilo Synjardy lahko povzroči zelo redek, a zelo resen neželeni učinek, imenovan laktacidoza, zlasti če ledvice ne delujejo pravilno.
English: Glucocorticoids (given by systemic and local routes), beta 2 agonists, and diuretics have intrinsic hyperglycaemic activity.
Slovenian: Glukokortikoidi (pri sistemski in lokalni uporabi), agonisti beta-2 in diuretiki imajo intrinzično hiperglikemično delovanje.
English: The reduction of cardiovascular death was comparable for empagliflozin 10 mg and 25 mg (see Figure 1) and confirmed by an improved overall survival (Table
Slovenian: Znižanje srčno-žilne smrtnosti je bilo primerljivo za empagliflozin 10 mg in 25 mg (slika 1) in dokazano z izboljšanjem celokupnega preživetja (preglednica 9).
English: Increased urinary glucose excretion was maintained at the end of the 4-week treatment period, averaging approximately 78 g/day with empagliflozin 25 mg.
Slovenian: Povečano izločanje glukoze z urinom se je ohranilo do konca 4-tedenskega obdobja zdravljenja in je bilo pri empagliflozinu 25 mg povprečno 78 g/dan.
English: Treatment with empagliflozin once daily resulted in statistically significant improvement in HbA1c, and 24 hour mean systolic and diastolic blood pressure as determined by ambulatory blood pressure monitoring (Table 10).
Slovenian: Zdravljenje z empagliflozinom enkrat na dan je povzročilo statistično značilno izboljšanje HbA1c in 24-urnega povprečnega sistoličnega in diastoličnega krvnega tlaka, kot je bilo ugotovljeno z ambulantnim spremljanjem krvnega tlaka (preglednica 10).
English: In this analysis, AUC was estimated to be 5.82%, 10.4%, and 17.3% lower in subjects with BMI of 30, 35, and 45 kg/m2, respectively, compared to subjects with a body mass index of 25 kg/m
Slovenian: V tej analizi so ocenili, da je vrednost AUC za 5,82 %, 10,4 % oz. 17,3 % nižja pri osebah z ITM 30, 35 oz. 45 kg/m2 v primerjavi z osebami z indeksom telesne mase 25 kg/m
English: Empagliflozin does not inhibit other glucose transporters important for glucose transport into peripheral tissues and is 5000-times more selective for SGLT2 versus SGLT1, the major transporter responsible for glucose absorption in the gut.
Slovenian: Empagliflozin ne zavira drugih prenašalcev glukoze, pomembnih za prenašanje glukoze v periferna tkiva, in je 5.000-krat bolj selektiven za SGLT2 v primerjavi z SGLT1, glavnim prenašalcem, odgovornim za absorpcijo glukoze v črevesju.
English: • feeling sick (nausea), vomiting
Slovenian: • občutek slabosti (navzea), bruhanje;
English: • Acute conditions with the potential to alter renal function such as: dehydration, severe infection,
Slovenian: • Akutna stanja, ki bi lahko spremenila delovanje ledvic, kot so: dehidracija, huda okužba, šok.
English: Your doctor may ask you to stop taking Synjardy.
Slovenian: Vaš zdravnik vam bo morda naročil, da prenehate jemati zdravilo Synjardy.
English: At Week 52, treatment with empagliflozin resulted in a statistically significant decrease in HbA1c and insulin sparing compared with placebo and a reduction in body weight.
Slovenian: V 52. tednu je zdravljenje z empagliflozinom povzročilo statistično značilno zmanjšanje vrednosti HbA1c, varčevanje z insulinom v primerjavi s placebom in zmanjšanje telesne mase.
English: The glucosuria, natriuresis and osmotic diuresis observed with empagliflozin may contribute to the improvement in cardiovascular outcomes.
Slovenian: Glukozurija, natriureza in osmotska diureza, ki jih opažamo pri empagliflozinu, lahko prispevajo k izboljšanju srčno-žilnih izidov.
English: High overdose of metformin or concomitant risks may lead to lactic acidosis.
Slovenian: Hudo predoziranje metformina ali sočasni dejavniki tveganja lahko povzročijo laktacidozo.
English: Multiple-dose study: After repeated doses of 500 mg twice daily for 7 days in paediatric patients the peak plasma concentration (Cmax) and systemic exposure (AUC0-t) were approximately 33% and 40% lower, respectively, compared to diabetic adults who received repeated doses of 500 mg twice daily for 14 days.
Slovenian: Študija z večkratnimi odmerki: Po ponavljajočih odmerkih 500 mg, ki so jih dvakrat dnevno 7 dni prejemali pediatrični bolniki, sta bili pri njih največja koncentracija v plazmi (Cmax) za približno 33 % in sistemska izpostavljenost (AUC0-t) za približno 40 % manjši v primerjavi z vrednostmi pri odraslih bolnikih, ki so prejemali ponavljajoče odmerke po 500 mg dvakrat dnevno 14 dni.
English: • reduced body temperature and heartbeat
Slovenian: • znižano telesno temperaturo in počasen srčni utrip.
English: Inducers of OCT1 (such as rifampicin) may increase gastrointestinal absorption and efficacy of metformin.
Slovenian: • induktorji OCT1 (npr. rifampicin) lahko poveča obseg gastrointestinalne absorpcije in učinkovitost metformina,
English: Hepatic impairment This medicinal product must not be used in patients with hepatic impairment (see sections 4.3, 4.4 and
Slovenian: Jetrna okvara Tega zdravila se ne sme uporabljati pri bolnikih z jetrno okvaro (glejte poglavja 4.3, 4.4 in 5.2).
English: At exposures sufficiently in excess of exposure in humans after therapeutic doses, empagliflozin had no adverse effects on fertility or early embryonic development.
Slovenian: Pri izpostavljenostih, ki so pomembno večje od izpostavljenostih pri ljudeh po terapevtskih odmerkih, empagliflozin ni imel neželenih učinkov na sposobnost razmnoževanja ali zgodnji razvoj zarodka.
English: Increased urination
Slovenian: Pogostejše uriniranje
English: Symptoms include stomach pain, fast and deep breathing, sleepiness or your breath developing an unusual fruity smell;
Slovenian: Simptomi vključujejo bolečine v trebuhu, hitro in globoko dihanje, zaspanost ali zadah z nenavadnim sadnim vonjem;
English: Restarting SGLT2 inhibitor treatment in patients with previous DKA while on SGLT2 inhibitor treatment is not recommended, unless another clear precipitating factor is identified and resolved.
Slovenian: Pri bolnikih, pri katerih se je v preteklosti med zdravljenjem z zaviralcem SGLT2 pojavila diabetična ketoacidoza, ponovna uvedba zaviralca SGLT2 ni priporočljiva, razen če je ugotovljen in odpravljen kakšen drug nedvomen sprožilni dejavnik.
English: The treatment effect was driven by a significant reduction in cardiovascular death with no significant change in non-fatal myocardial infarction, or non-fatal stroke.
Slovenian: Vodilo učinkov zdravljenja je bilo statistično pomembno zmanjšanje srčno-žilne smrti, pri čemer pri miokardnem infarktu brez smrtnega izida in možganski kapi brez smrtnega izida ni prišlo do statistično pomembnih sprememb.
English: The effect of empagliflozin on urinary glucose excretion is associated with osmotic diuresis, which could affect hydration status of patients age 75 years and older.
Slovenian: Učinek empagliflozina na izločanje glukoze v seču je povezan z osmotsko diurezo, kar lahko vpliva na stanje hidracije bolnikov, starih 75 let in več.
English: The risk of diabetic ketoacidosis must be considered in the event of non-specific symptoms such as nausea, vomiting, anorexia, abdominal pain, excessive thirst, difficulty breathing, confusion, unusual fatigue or sleepiness.
Slovenian: Na možnost diabetične ketoacidoze je treba pomisliti, če se pojavijo nespecifični simptomi, kot so slabost, bruhanje, anoreksija, bolečine v trebuhu, prekomerna žeja, oteženo dihanje, zmedenost, neobičajna utrujenost ali zaspanost.
English: Your doctor will normally start Synjardy treatment by prescribing the strength of tablet that supplies the same dose of metformin you are already taking (850 mg or 1,000 mg twice a day), and the lowest dose of empagliflozin (5 mg twice a day).
Slovenian: Zdravnik vam bo pri uvajanju zdravljenja z zdravilom Synjardy običajno predpisal jakost zdravila, s katero boste dobili enak odmerek metformina, ki ga trenutno že prejemate (850 mg ali 1.000 mg dvakrat na dan), in najnižji odmerek empagliflozina (5 mg dvakrat na dan).
English: Initial increases in creatinine and initial decreases in estimated glomerular filtration rates in patients treated with empagliflozin as add-on to metformin therapy were generally transient during continuous treatment or reversible after drug discontinuation of treatment.
Slovenian: Začetna zvišanja ravni kreatinina in začetna zmanjšanja predvidene hitrosti glomerularne filtracije pri bolnikih, zdravljenih z empagliflozinom kot dodatno zdravljenje k metforminu, so bila praviloma prehodna med neprekinjenim zdravljenjem ali reverzibilna po prenehanju zdravljenja.