FrancophonIA/ELRC3.0 huggingface dataset:
English: It is important to take Xaluprine in the evening to make the medicine more effective.
Slovenian: Pomembno je, da zdravilo Xaluprine jemljete zvečer, saj je tako učinkovitejše.
English: 6-mercaptopurine has been identified in the colostrum and breast-milk of women receiving azathioprine treatment and thus women receiving Xaluprine should not breast-feed.
Slovenian: 6-merkaptopurin so našli v kolostrumu in v mleku žensk, ki so jemale azatioprin, zato ženske, ki se zdravijo z zdravilom Xaluprine, ne smejo dojiti.
English: As this medicine contains sucrose, patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Slovenian: Ker zdravilo vsebuje saharozo, ga ne smejo jemati bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkanjem saharoze-izomaltaze.
English: This is usually reversible if 6-mercaptopurine therapy is stopped soon enough but fatal liver damage has occurred.
Slovenian: Ta je običajno reverzibilna, če se zdravljenje s 6-merkaptopurinom prekine dovolj zgodaj, vendar pa že pride do jetrne okvare s smrtnim izidom.
English: Depending on phase of treatment, starting or target doses generally vary between 25-75 mg/m2 body surface area (BSA) per day, but should be lower in patients with reduced or absent Thiopurine Methyl Transferase (TPMT) enzyme activity (see section 4.4).
Slovenian: Glede na fazo zdravljenja je začetni ali ciljni odmerek običajno med 25 in 75 mg/m2 telesne površine (TP) na dan, pri bolnikih z zmanjšanim delovanjem encima tiopurin metiltransferaza (TPMT) ali brez delovanja tega encima pa manjši (glejte poglavje 4.4).
English: Other xanthine oxidase inhibitors should be avoided (see section 4.5).
Slovenian: Uporabi drugih zaviralcev ksantin-oksidaze se je treba izogibati (glejte poglavje 4.5).
English: If you are already pregnant, you must talk to your doctor before taking Xaluprine.
Slovenian: Če ste že noseči, se morate pred jemanjem zdravila Xaluprine posvetovati z zdravnikom.
English: Therefore close monitoring of blood counts is necessary.
Slovenian: Zato je potrebno pozorno spremljanje števila krvnih celic.
English: Xaluprine is hepatotoxic and liver function tests should be monitored weekly during treatment.
Slovenian: Zdravilo Xaluprine je hepatotoksično in med zdravljenjem je potrebno tedensko spremljanje delovanja jeter.
English: If you accidentally get some in your eyes or nose, flush the area with water.
Slovenian: Če nekaj zdravila kljub temu pride v oči ali nos, predel izperite z vodo.
English: Therefore, immunisations with live organism vaccines are not recommended.
Slovenian: Zato cepljenje z živimi cepivi ni priporočljivo.
English: When oral anticoagulants are coadministered with 6-mercaptopurine, a reinforced monitoring of INR (International Normalised Ratio) is recommended (see section 4.5).
Slovenian: Če se sočasno s 6-merkaptopurinom dajejo peroralni antikoagulanti, je priporočljivo okrepljeno spremljanje INR (mednarodno normalizirano razmerje) (glejte poglavje 4.5).
English: Ensure that the cap is tightly closed.
Slovenian: Prepričajte se, da je zaporka tesno zaprta.
English: Other medicines and Xaluprine
Slovenian: Druga zdravila in zdravilo Xaluprine
English: - Any yellowing of the whites of the eyes or skin (jaundice)
Slovenian: Porumenelost očesne beločnice ali kože (zlatenica)
English: 6-mercaptopurine causes embryolethality and severe teratogenic effects in the mouse, rat, hamster and rabbit at doses that are non-toxic to the mother.
Slovenian: 6-merkaptopurin povzroča smrtnost zarodkov in hude teratogene učinke pri miših, podganah, hrčkih in zajcih pri odmerkih, ki za mater niso toksični.
English: This belongs to a group of medicines called cytotoxics (also called chemotherapy).
Slovenian: Ta sodi v skupino zdravil, imenovanih citotoksična zdravila (kemoterapija).
English: When allopurinol and 6-mercaptopurine are administered concomitantly it is essential that only a quarter of the usual dose of 6-mercaptopurine is given.
Slovenian: Pri sočasni uporabi alopurinola in 6-merkaptopurina je zelo pomembno, da se uporablja samo ena četrtina običajnega odmerka 6-merkaptopurina.
English: When you are treated with Xaluprine the risk of viral, fungal and bacterial infections is increased and the infections may be more serious.
Slovenian: Med zdravljenjem z zdravilom Xaluprine se lahko poveča tveganje virusnih, glivičnih in bakterijskih okužb, ki so lahko resnejše.
English: - Any signs of fever or infection (sore throat, sore mouth or urinary problems)
Slovenian: Kateri koli znaki povišane telesne temperature ali okužbe (vneto grlo, vneta ustna sluznica ali težave s sečili)
English: Do not store above 25ºC.
Slovenian: - Shranjujte pri temperaturi pod 25 °C.
English: Hydration and urine alkalinisation may minimize potential renal complications.
Slovenian: Zadostna oskrba s tekočino in alkalinizacija urina lahko zmanjšata tveganje možnih ledvičnih zapletov.
English: Some patients with inflammatory bowel disease who have received 6-mercaptopurine have developed a rare and aggressive type of cancer called Hepatosplenic T-cell Lymphoma (see section 4, Possible side effects).
Slovenian: Pri nekaterih bolnikih z vnetno črevesno boleznijo, ki so prejeli 6-merkaptopurin, se je razvila redka in agresivna oblika raka, imenovana hepatosplenični limfom celic T (glejte poglavje 4, Možni neželeni učinki).
English: The thioguanine nucleotides are also incorporated into nucleic acids and this contributes to the cytotoxic effects of the active substance.
Slovenian: Nukleotidi tiogvanina so tudi vgrajeni v nukleinske kisline, kar vpliva na citotoksične učinke učinkovine.
English: 6-mercaptopurine displays diurnal variation in pharmacokinetics and efficacy.
Slovenian: Pri 6-merkaptopurinu se kažejo dnevne spremembe v farmakokinetiki in učinkovitosti.
English: Xaluprine should only be given to you by a specialist doctor who is experienced in treating blood problems.
Slovenian: Zdravilo Xaluprine vam lahko da samo zdravnik specialist, ki ima izkušnje z zdravljenjem krvnih bolezni.
English: If you get any of the following side effects, talk to your specialist doctor or go to hospital immediately:
Slovenian: Če se pri vas pojavijo navedeni neželeni učinki, se nemudoma posvetujte z zdravnikom specialistom ali pojdite v bolnišnico:
English: Date of latest renewal: 18 November 2016
Slovenian: Datum zadnjega podaljšanja: 18.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Slovenian: • Redno posodobljena poročila o varnosti zdravila (PSUR) Zahteve glede predložitve rednega posodobljenega poročila o varnosti zdravila za to zdravilo so določene v seznamu referenčnih datumov Unije (seznamu EURD), opredeljenem v členu 107c(7)
English: You should use this one if the total amount you have to take is less than or equal to 1 ml (each graduation of 0.1 ml contains 2 mg of mercaptopurine).
Slovenian: To brizgo uporabite, če je odmerek, ki ga morate vzeti, manjši ali enak 1 ml (vsaka merilna oznaka 0,1 ml pomeni 2 mg merkaptopurina).
English: Switching between tablet and oral suspension and vice versa A tablet form of 6-mercaptopurine is also available.
Slovenian: Prehod med tabletami in peroralno suspenzijo ter obratno 6-merkaptopurin je na voljo tudi v obliki tablet.
English: Gastrointestinal effects, including nausea, vomiting and diarrhoea and anorexia may be early symptoms of overdose having occurred.
Slovenian: Simptomi in znaki Učinki na prebavila, vključno z navzeo, bruhanjem in drisko ter anoreksijo so lahko zgodnji simptomi,
English: - Keep the bottle tightly closed to prevent spoilage of the medicine and reduce the risk of accidental spillage.
Slovenian: - Steklenica naj bo tesno zaprta, da ne pride do razlitja zdravila in da zmanjšate tveganje nenamernega razlitja.
English: Prior exposure to or infection with varicella zoster virus should be taken into consideration prior to starting treatment.
Slovenian: Pred začetkom zdravljenja je treba preveriti predhodno izpostavljenost virusu varicella zoster ali okužbo z njim.
English: Do not take Xaluprine if you are planning to have a baby without first speaking to your doctor for advice.
Slovenian: Ne jemljite zdravila Xaluprine, če načrtujete nosečnost, ne da bi se o tem prej posvetovali z zdravnikom.
English: Patients receiving immunosuppressive therapy, including mercaptopurine, are at an increased risk of developing lymphoproliferative disorders and other malignancies, notably skin cancers (melanoma and non-melanoma), sarcomas (Kaposi's and non-Kaposi's) and uterine cervical cancer in situ.
Slovenian: Bolniki, ki prejemajo imunosupresivno terapijo, vključno z merkaptopurinom, so izpostavljeni povečanemu tveganju za pojav limfoproliferativnih bolezni in drugih malignih bolezni, predvsem kožnega raka (melanomskega in nemelanomskega), sarkoma (Kaposijevega in ne-Kaposijevega) ter raka materničnega vratu in situ.
English: Careful monitoring of haematological parameters should be conducted during therapy.
Slovenian: Med zdravljenjem je treba pozorno spremljati hematološke parametre.
English: The leucocyte and platelet counts continue to fall after treatment is stopped, so at the first sign of an abnormally large fall in the counts, treatment should be interrupted immediately.
Slovenian: Število levkocitov in trombocitov se zmanjšuje tudi po prenehanju zdravljenja, zato je treba pri prvih znakih nenormalno velikega zmanjšanja števila zdravljenje takoj prekiniti.
English: Since impaired renal function may result in slower elimination of mercaptopurine and its metabolites and therefore a greater cumulative effect, consideration should be given to reduced starting doses in patients with impaired renal function.
Slovenian: Okvarjeno delovanje ledvic lahko povzroča počasnejše izločanje merkaptopurina in njegovih presnovkov ter s tem večji kumulativni učinek, zato je pri bolnikih z okvarjenim delovanjem ledvic treba razmisliti o manjšem začetnem odmerku zdravila.
English: The principal toxic effect is on the bone marrow, resulting in myelosuppression.
Slovenian: Glavni toksični učinek je na kostni mozeg in povzroča mielosupresijo.
English: There are individuals with an inherited deficiency of the TPMT enzyme activity who are very sensitive to the myelosuppresive effect of 6-mercaptopurine and prone to developing rapid bone marrow depression following the initiation of treatment with 6-mercaptopurine.
Slovenian: Nekateri ljudje z dedno oslabljenim delovanjem encima TPMT so zelo občutljivi na mielosupresivni učinek 6-merkaptopurina in nagnjeni k hitremu razvoju depresije kostnega mozga po začetku zdravljenja s 6-merkaptopurinom.
English: You should take your medicine at least 1 hour before or 2 hours after having milk or dairy products.
Slovenian: Zdravilo morate vzeti vsaj eno uro pred zaužitjem mleka ali mlečnih izdelkov ali dve uri po njem.
English: To assist accurate and consistent dose delivery to the stomach water should be taken after each dose of Xaluprine.
Slovenian: Za zagotovitev natančnega in enakomernega sproščanja odmerka v želodcu je treba po vsakem odmerku zdravila Xaluprine piti vodo.
English: Push the tip of the dosing syringe into the hole in the adaptor (figure 4).
Slovenian: Konico brizge za odmerjanje potisnite v luknjo v nastavku (Slika 4).
English: Parents / care givers and patients should be advised to keep Xaluprine out of the reach and sight of children, preferably in a locked cupboard.
Slovenian: Staršem/negovalcem in bolnikom je treba svetovati, da naj zdravilo Xalpurine shranjujejo nedosegljivo otrokom, po možnosti v zaklenjeni omari.
English: Store the syringe in a hygienic place with the medicine.
Slovenian: Brizgo shranjujete na čistem mestu skupaj z zdravilom.
English: Tell your doctor before starting treatment whether or not you have had chickenpox, shingles or hepatitis B (a liver disease caused by a virus).
Slovenian: Pred začetkom zdravljenja zdravniku povejte, če ste preboleli norice, herpes zoster (pasovec) ali hepatitis B (jetrno bolezen, ki jo povzroča virus).
English: NUDT15-gene mutation
Slovenian: Mutacija gena NUDT15
English: No studies on the effect on the ability to drive and use machines have been performed.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji Študij vpliva na sposobnost vožnje in upravljanja s stroji niso izvajali.
English: Patients with little or no inherited TPMT activity are at increased risk for severe toxicity from conventional doses of mercaptopurine and generally require substantial dose reduction.
Slovenian: Pri bolnikih z zmanjšanim delovanjem ali dednim nedelovanjem TPMT obstaja povečano tveganje za hudo toksičnost pri uporabi običajnih odmerkov merkaptopurina, zaradi česar je treba običajno bistveno zmanjšati odmerek.
English: In view of its action on cellular deoxyribonucleic acid (DNA) 6-mercaptopurine is potentially carcinogenic and consideration should be given to the theoretical risk of carcinogenesis with this treatment.
Slovenian: Ker 6-merkaptopurin deluje na celično deoksiribonukleinsko kislino (DNA), je potencialno kancerogen, pri zdravljenju pa je treba upoštevati tudi možno teoretično tveganje za kancerogenezo.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Take as directed by your doctor using the dosing syringes provided.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Jemljite po zdravnikovih navodilih z uporabo priloženih brizg za odmerjanje.
English: During remission induction when rapid cell lysis is occurring, uric acid levels in blood and urine should be monitored as hyperuricaemia and/or hyperuricosuria may develop, with the risk of uric acid nephropathy.
Slovenian: Toksičnost za ledvice Med indukcijo remisije, ko prihaja do hitre celične lize, je treba spremljati vrednost sečne kisline v krvi in urinu, saj se lahko razvije hiperurikemija in/ali hiperurikozurija s tveganjem nefropatije zaradi sečne kisline.
English: The first step is catalysed by hypoxanthine-guanine phosphoribosyl transferase yielding thioinosine monophosphate (TIMP).
Slovenian: Prvi korak katalizira hipoksantin-gvanin-fosforibozil-transferaza, ki tvori tioinozin monofosfat (TIMP).
English: Both TIMP and mTIMP are inhibitors of phosphoribosyl pyrophosphate amidotransferase, an enzyme which is important in de novo purine synthesis.
Slovenian: Tako TIMP kot mTIMP sta zaviralca fosforibozil-pirofosfat-amidotransferaze, encima, ki je pomemben pri de novo sintezi purina.
English: Concomitant use with yellow fever vaccine (see section 4.5)
Slovenian: Sočasna uporaba s cepivom proti rumeni mrzlici (glejte poglavje 4.5).
English: Secondary leukaemia and myelodysplasia
Slovenian: Sekundarna levkemija in mielodisplazija
English: Photosensitivity reaction
Slovenian: Občutljivostna reakcija na svetlobo
English: Xaluprine is used for acute lymphoblastic leukaemia (also called acute lymphocytic leukaemia or ALL).
Slovenian: Zdravilo Xaluprine se uporablja za akutno limfoblastno levkemijo (imenovano tudi akutna limfocitna levkemija ali ALL).
English: Carcinogenicity Given its genotoxic potential, 6-mercaptopurine is potentially carcinogenic.
Slovenian: Ob upoštevanju genotoksičnega potenciala 6-merkaptopurina je le-ta potencialno kancerogen.
English: Haematological toxicity is likely to be more profound with chronic overdose than with a single ingestion of Xaluprine.
Slovenian: Verjetno je, da do izrazitejše hematološke toksičnosti pride pri kroničnem prevelikem odmerjanju in ne pri enkratnem zaužitju zdravila Xaluprine.
English: Effects of other medicinal products on mercaptopurine When allopurinol and Xaluprine are administered concomitantly it is essential that only a quarter of the usual dose of Xaluprine is given since allopurinol decreases the rate of metabolism of 6-mercaptopurine via xanthine oxidase.
Slovenian: Učinki drugih zdravil na merkaptopurin Pri sočasni uporabi alopurinola in zdravila Xaluprine je zelo pomembno, da se uporablja le četrtina siceršnjega odmerka zdravila Xaluprine, saj alopurinol zmanjšuje hitrost presnavljanja 6-merkaptopurina prek ksantin-oksidaze.
English: Combination with xanthine oxidase inhibitors
Slovenian: Kombiniranje z zaviralci ksantin-oksidaze
English: Always use the syringes provided to take your medicine.
Slovenian: Za jemanje zdravila vedno uporabite priloženi brizgi.
English: If you forget to take Xaluprine
Slovenian: Če ste pozabili vzeti zdravilo Xaluprine
English: The smaller 1 ml syringe (purple), marked from 0.1 ml to 1 ml, is for measuring doses of less than or equal to 1 ml.
Slovenian: Manjša 1 ml brizga (vijolična) je označena z lestvico od 0,1 do 1 ml in je namenjena odmerjanju odmerkov, manjših ali enakih 1 ml.
English: Pull the plunger back to the point on the scale that corresponds to the dose prescribed (figure 5).
Slovenian: Nato bat brizge potisnite na položaj na merilni lestvic, ki ustreza vašemu predpisanemu odmerku (Slika 5).
English: Approximately 7% of an oral dose is excreted as unchanged 6-mercaptopurine within 12 hours after administration.
Slovenian: peroralnega odmerka se izloča kot nespremenjen 6-merkaptopurin v 12 urah po uporabi.
English: Xaluprine should be taken at least 1 hour before or 2 hours after milk or dairy products.
Slovenian: Zdravilo Xaluprine se mora vzeti vsaj eno uro pred zaužitjem mleka ali mlečnih izdelkov ali dve uri po njem.
English: - Sensitivity to sunlight causing skin reactions
Slovenian: - občutljivost na sončno svetlobo, ki povzroča kožne reakcije Dodatni neželeni učinki pri otrocih
English: This may be harmful for people with phenylketonuria.
Slovenian: Škoduje lahko ljudem s fenilketonurijo.
English: Evidence of the teratogenicity of 6-mercaptopurine in humans is equivocal.
Slovenian: Dokazi o teratogenosti 6-merkaptopurina pri ljudeh niso zanesljivi.
English: To decrease the risk of exposure, parents and care givers should wear disposable gloves when handling Xaluprine.
Slovenian: Za zmanjšanje tveganja izpostavljenosti naj starši in negovalci pri uporabi zdravila Xaluprine uporabljajo rokavice za enkratno uporabo.
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, purine analogues, ATC code: L01BB02
Slovenian: Farmakoterapevtska skupina: antineoplastiki, antimetaboliti, analogi purinskih baz, oznaka ATC:
English: Patients with inherited mutated NUDT15 gene are at increased risk for severe 6-mercaptopurine toxicity, (see 4.4).
Slovenian: Bolniki s podedovanim mutiranim genom NUDT15 so izpostavljeni povečanemu tveganju za hudo toksičnost zaradi 6-merkaptopurina (glejte poglavje 4.4).
English: If you take more Xaluprine than you should, tell your doctor or go to a hospital immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Xaluprine, kot bi smeli Če ste vzeli večjo količino zdravila Xaluprine, kot bi smeli, nemudoma pokličite zdravnika ali pojdite v bolnišnico.
English: Avoid contact of Xaluprine with your skin, eyes or nose.
Slovenian: Pazite, da zdravilo Xaluprine ne pride v stik s kožo, očmi ali nosom.
English: *inflammatory bowel disease (IBD) is an unlicensed indication
Slovenian: *vnetna črevesna bolezen je indikacija, ki ni odobrena
English: Hepatosplenic T-cell lymphoma* (see section 4.4)
Slovenian: Jetrnovranični T-celični limfom* (glejte poglavje 4.4)
English: 6-mercaptopurine is an inactive pro-drug which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides for cytotoxicity.
Slovenian: 6-merkaptopurin je neaktivno predzdravilo, ki deluje kot antagonist purina, vendar je potreben celični privzem in znotrajcelični anabolizem v nukleotide tiogvanina za citotoksičnost.
English: Take the medicine pack and this leaflet with you.
Slovenian: Ovojnino zdravila in navodilo za uporabo vzemite s seboj.
English: The 6-mercaptopurine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions.
Slovenian: Presnovki 6-merkaptopurina zavirajo de novo sintezo purina in interkonverzijo purinskih nukleotidov.
English: Biliary stasis, hepatotoxicity
Slovenian: Zastoj žolča, hepatotoksičnost
English: Xaluprine contains aspartame (E951) which contains a source of phenylalanine.
Slovenian: Zdravilo Xaluprine vsebuje aspartam (E951), ki je izvor fenilalanina.
English: If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Xaluprine.
Slovenian: Če niste prepričani, ali kaj od naštetega velja za vas, se pred jemanjem zdravila Xaluprine posvetujte z zdravnikom ali s farmacevtom.
English: The histological findings in man have shown hepatic necrosis and biliary stasis
Slovenian: Histološke ugotovitve pri ljudeh so pokazale nekrozo jeter in zastoj žolča.
English: The intracellular anabolism of 6-merpactopurine is catalysed by several enzymes to eventually form 6-thioguanine nucleotides (TGNs), but a variety of intermediary TGNs are formed en route to the TGNs.
Slovenian: Znotrajcelični anabolizem 6-merkaptopurina se katalizira z več encimi, ki ga v končni fazi pretvorijo v 6-tiogvanin nukleotide (TGN), vendar se v postopku do oblikovanja končnih TGN oblikuje več vmesnih TGN.
English: Wash the syringe with warm ‘soapy' water and rinse well.
Slovenian: Brizgo operite s toplo milnico in jo dobro sperite.
English: Xaluprine should not be handled by women who are or planning to be pregnant or breast-feeding.
Slovenian: Z zdravilom Xaluprine ne smejo rokovati ženske, ki so noseče, načrtujejo nosečnost ali dojijo.
English: TPMT genotyping or phenotyping can be used to identify patients with absent or reduced TPMT activity.
Slovenian: Za ugotavljanje, ali pri bolnikih ni delovanja TPMT ali pa je zmanjšano, se lahko uporablja genotipizacija ali fenotipizacija TPMT.
English: 6-mercaptopurine is metabolised by the polymorphic TPMT enzyme.
Slovenian: 6-merkaptopurin se presnavlja s polimorfnim encimom TPMT.
English: The larger 5 ml syringe (white), marked 1 ml to 5 ml, is for measuring doses of more than 1 ml.
Slovenian: Večja 5 ml brizga (bela) je označena z lestvico od 1 ml do 5 ml in je namenjena odmerjanju odmerkov, večjih od 1 ml.
English: Special populations
Slovenian: Posebne populacije Starejši:
English: It comes in glass bottles of 100 ml capped with a child-resistant closure.
Slovenian: Na voljo je v 100 ml steklenici, ki je zaprta z zaporko, varno za otroke.
English: These patients generally require dose reduction; particularly those being NUDT15 variant homozygotes (see 4.4).
Slovenian: Pri teh bolnikih je običajno potrebno zmanjšanje odmerka, predvsem pri homozigotnih variantah NUDT15 (glejte poglavje 4.4).
English: However, it is advisable to monitor renal and hepatic function in these patients, and if there is any impairment, consideration should be given to reducing the Xaluprine dose.
Slovenian: Pri teh bolnikih se priporoča spremljanje delovanja ledvic in jeter, v primeru kakršne koli okvare pa je treba proučiti možnost zmanjšanja odmerka zdravila Xaluprine.
English: Two dosing syringes (a purple syringe graduated to 1 ml and a white syringe graduated to 5 ml) are provided for accurate measurement of the prescribed dose of the oral suspension.
Slovenian: Priloženi sta dve brizgi za odmerjanje (vijolična brizga z merilno skalo do 1 ml in bela brizga z merilno skalo do 5 ml) za natančno odmerjanje predpisanega odmerka peroralne suspenzije.
English: Wipe up spillages immediately.
Slovenian: Razlitje zdravila nemudoma obrišite.
English: Allopurinol and other xanthine oxidase inhibitors decrease the rate of catabolism of 6-mercaptopurine.
Slovenian: Alopurinol in drugi zaviralci ksantin-oksidaze zmanjšujejo hitrost razgradnje 6-merkaptopurina.
English: If Xaluprine comes into contact with skin, eyes or nose, it should be washed immediately and thoroughly with soap and water.
Slovenian: Če pride zdravilo Xaluprine v stik s kožo, očmi ali nosom, ga morate takoj temeljito izprati z milom in vodo.
English: Keep the bottle tightly closed to protect the integrity of the product and minimise the risk of accidental spillage.
Slovenian: Steklenica naj bo tesno zaprta, da je zagotovljena integriteta zdravila in se zmanjša tveganje nenamernega razlitja.