FrancophonIA/ELRC3.0 huggingface dataset:
English: A single 245 mg dose of tenofovir disoproxil was administered to non-HIV infected patients with varying degrees of hepatic impairment defined according to CPT classification.
Croatian: Jednokratna doza od 245 mg tenofovirdizoproksila dana je bolesnicima koji nisu bili inficiranih virusom HIV-a, a imali su različit stupanj oštećenja funkcije jetre prema klasifikaciji CPT.
English: In a 144-week open-label randomised clinical study (GS-01-934) antiretroviral treatment-naïve HIV-1 infected patients received either a once-daily regimen of efavirenz, emtricitabine and tenofovir disoproxil or a fixed combination of lamivudine and zidovudine (Combivir) administered twice daily and efavirenz once daily (please refer to the Summary of Product Characteristics for Truvada).
Croatian: U otvorenom randomiziranom kliničkom ispitivanju (GS-01-934) u trajanju od 144 tjedana, bolesnici inficirani virusom HIV-1 koji prije nisu bili liječeni antiretrovirusnom terapijom primali su ili efavirenz, emtricitabin i tenofovirdizoproksil po režimu doziranja jedanput na dan ili fiksnu kombinaciju lamivudina i zidovudina (Combivir) davanu dva puta na dan te efavirenz jedanput na dan (pročitajte sažetak opisa svojstava lijeka za Truvadu).
English: Atripla and vigabatrin or gabapentin can be coadministered without dose adjustment.
Croatian: Atripla i vigabatrin ili gabapentin mogu se primjenjivati istodobno bez prilagođavanja doze.
English: Rare completed suicide3,4, delusion3,4, neurosis3,4 Nervous system disorders: Very common headache dizziness
Croatian: Rijetko izvršeno samoubojstvo3,4, deluzija3,4, neuroza3,4
English: • inflammation of the kidney, passing a lot of urine and feeling thirsty
Croatian: • upala bubrega, mokrenje velikih količina mokraće i osjećaj žeđi
English: St. John's wort (Hypericum perforatum): Co-administration of Atripla and St. John's wort or herbal preparations containing St. John's wort is contraindicated.
Croatian: Gospina trava (Hypericum perforatum): Istodobna primjena Atriple i gospine trave ili biljnih pripravaka koji sadržavaju gospinu travu je kontraindicirana.
English: Co-administration with other medicinal products
Croatian: Istodobna primjena s drugim lijekovima
English: In the prior-NNRTI stratum, response rates were 98.9% vs 97.4% for Atripla and SBR patients respectively; a difference (95%CI) of 1.4% (-4.0%, 6.9%)].
Croatian: U skupini bolesnika koji su prethodno liječeni NNRTI lijekovima stope odgovora bile su 98,9% u bolesnika koji su primali Atriplu u usporedbi s 97,4% u SBR bolesnika: razlika (95%CI) od 1,4% (-4,0%, 6,9%)].
English: Concomitant use of Ginkgo biloba extracts is not recommended (see section 4.5).
Croatian: Ne preporučuje se istodobna primjena ekstrakta Ginkgo bilobe (vidjeti dio 4.5).
English: Artemether/Lumefantrine/Efavirenz (20/120 mg tablet, 6 doses of 4 tablets each over 3 days/600 mg q.d.)
Croatian: Antimalarici artemeter/lumefantrin/efavirenz (tableta od 20/120 mg, 6 doza po 4 tablete tijekom 3 dana/600mg q.d.)
English: Serious birth defects have been seen in unborn animals and in the babies of women treated with efavirenz during pregnancy.
Croatian: U nerođenih životinja i djece žena koje su tijekom trudnoće uzimale efavirenz zabilježeni su ozbiljne urođene mane.
English: Due to similarities with emtricitabine, Atripla should not be administered concomitantly with other cytidine analogues, such as lamivudine (see section 4.5).
Croatian: Zbog sličnosti s emtricitabinom, Atripla se ne smije primjenjivati zajedno s drugim analozima citidina, kao što je lamivudin (vidjeti dio 4.5).
English: Implant: Etonogestrel/Efavirenz
Croatian: Implantat: etonogestrel/efavirenz
English: Pregnancy should be avoided in women receiving Atripla.
Croatian: Žene koje primaju Atriplu trebaju izbjegavati trudnoću.
English: Carbamazepine:
Croatian: karbamazepin:
English: ANTI-INFECTIVES HIV antivirals
Croatian: ANTIINFEKTIVNI LIJEKOVI
English: Co-administration of Atripla and sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/voxilaprevir is not recommended since plasma concentrations of velpatasvir and voxilaprevir are expected to decrease following co-administration with efavirenz leading to reduced therapeutic effect of sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/voxilaprevir (see section 4.5).
Croatian: Istodobna primjena Atriple i sofosbuvira/velpatasvira ili sofosbuvira/velpatasvira/voksilaprevira se ne preporučuje jer se očekuje da će se koncentracija velpatasvira i voksilaprevira u plazmi smanjiti nakon istodobne primjene s efavirenzom što će dovesti do smanjenog terapijskog učinka sofosbuvira/velpatasvira ili sofosbuvira/velpatasvira/voksilaprevira (vidjeti dio 4.5).
English: - Medicines used to treat convulsions/seizures (anticonvulsants): Carbamazepine, phenytoin,
Croatian: - Lijekovi koji se koriste za liječenje konvulzija/napadaja (antikonvulzivi): karbamazepin, fenitoin, fenobarbital.
English: While the clinical significance of decreased indinavir concentrations has not been established, the magnitude of the observed pharmacokinetic interaction should be taken into consideration when choosing a regimen containing both efavirenz, a component of Atripla, and indinavir.
Croatian: Iako nije ustanovljen klinički značaj smanjenih koncentracija indinavira, prilikom odabira režima koji sadrži i komponentu Atriple efavirenz i indinavir nužno je uzeti u obzir opseg farmakokinetičke interakcije.
English: • pain in the abdomen (stomach), caused by inflammation of the pancreas
Croatian: • bol u trbuhu prouzrokovana upalom gušterače
English: Elderly patients are more likely to have decreased hepatic or renal function, therefore caution should be exercised when treating elderly patients with Atripla (see section 4.2).
Croatian: Kod starijih je osoba veća vjerojatnost da imaju smanjenu funkciju jetre ili bubrega pa je stoga nužan oprez kad se starije osobe liječe Atriplom (vidjeti dio 4.2).
English: -0.5% (-3.2% to 2.2%)
Croatian: -0,5% (-3,2% do 2,2%)
English: AUC: ↔* (↓ 9% to ↑ 10%) Cmax: ↑ 17%* (↑ 8 to ↑ 27) Cmin: ↓ 42%* (↓ 31 to ↓ 51)
Croatian: AUC: ↔* (↓ 9% do ↑ 10%) Cmax: ↑ 17%* (↑ 8 do ↑ 27) Cmin: ↓ 42%* (↓ 31 do ↓ 51)
English: Eye disorders: Uncommon vision blurred
Croatian: Poremećaji oka: Manje često zamućen vid
English: There were no clinically significant pharmacokinetic interactions when emtricitabine was administered with stavudine, zidovudine or famciclovir.
Croatian: Nema klinički značajnih farmakokinetičkih interakcija kada se emtricitabin primjenjuje zajedno sa stavudinom, zidovudinom ili famciklovirom.
English: Following multiple dose oral administration of emtricitabine to 20 HIV infected patients, steady-state Cmax was 1.8 ± 0.7 µg/ml (mean ± S.D.) (39%CV), steady-state Cmin was 0.09 ± 0.07 µg/ml (80%) and the AUC was 10.0 ± 3.1 µg•h/ml (31%) over a 24 hour dosing interval.
Croatian: Nakon peroralnog davanja višekratnih doza emtricitabina 20 bolesnika inficiranih HIV-om, u 24-satnom intervalu doziranja vrijednosti Cmax u stanju dinamičke ravnoteže bile su 1,8 ± 0,7 µg/ml (srednja vrijednost ± SD) (39% CV), Cmin u stanju dinamičke ravnoteže 0,09 ± 0,07 µg/ml (80%) i AUC 10,0 ± 3,1 µg•h/ml (31%).
English: Proguanil:
Croatian: progvanil:
English: Patients must not have experienced virological failure on any prior antiretroviral therapy and must be known not to have harboured virus strains with mutations conferring significant resistance to any of the three components contained in Atripla prior to initiation of their first antiretroviral treatment regimen (see sections 4.4 and 5.1).
Croatian: Prije započinjanja prvog režima antiretrovirusnog liječenja, bolesnici nisu smjeli doživjeti virološki neuspjeh na bilo koju raniju antiretrovirusnu terapiju i mora biti ustanovljeno da nisu nosili sojeve virusa s mutacijama koje pokazuju značajnu rezistenciju na bilo koju od tri komponente koje sadržava Atripla (vidjeti dio 4.4 i
English: Since Atripla is a fixed-dose combination product, the dose of efavirenz cannot be altered; therefore, voriconazole and Atripla must not be co-administered (see section 4.3 and Table 1).
Croatian: Budući da je Atripla lijek s kombinacijom fiksnih doza, doza efavirenza se ne može mijenjati, što znači da se vorikonazol i Atripla ne smiju primjenjivati istodobno (vidjeti dio 4.3 i Tablicu 1).
English: Co-administration of Atripla and didanosine is not recommended since exposure to didanosine is significantly increased following co-administration with tenofovir disoproxil that may increase the risk of didanosine-related adverse reactions (see section 4.5).
Croatian: Ne preporučuje se istodobna primjena Atriple i didanozina jer se izloženost didanozinu značajno povećava u slučaju istodobne primjene tenofovirdizoproksila, što može povećati rizik od nuspojava povezanih s didanozinom (vidjeti dio 4.5).
English: It is recommended that Atripla be taken on an empty stomach since food may increase efavirenz exposure and may lead to an increase in the frequency of adverse reactions (see sections 4.4 and 4.8).
Croatian: Preporučuje se uzimanje Atriple na prazan želudac jer hrana može povećati izloženost efavirenzu i može dovesti do povećane učestalosti nuspojava (vidjeti dio 4.4 i 4.8).
English: Common pruritus vesiculobullous rash, pustular rash, maculopapular rash, rash, pruritus, urticaria, skin discolouration (increased pigmentation)1
Croatian: Često pruritus vezikulobulozni osip, pustulozni osip, makulopapulozni osip, osip, pruritus, urtikarija, promjena boje kože (pojačana pigmentacija)1
English: • decreases in phosphate levels in the blood
Croatian: • smanjene razine fosfata u krvi
English: (CYP3A4 induction) The increase in efavirenz pharmacokinetic parameters is not considered clinically significant.
Croatian: Povećanje parametara farmakokinetike efavirenza ne smatra se klinički značajnim.
English: Psychiatric adverse reactions have been reported in patients treated with efavirenz.
Croatian: Postoje izvješća o psihijatrijskim nuspojavama u bolesnika koji su uzimali efavirenz.
English: As a fixed combination, Atripla should not be administered concomitantly with other medicinal products containing the same active components, emtricitabine or tenofovir disoproxil.
Croatian: Atripla se, kao fiksna kombinacija, ne smije primjenjivati istodobno s drugim lijekovima koji sadržavaju iste djelatne komponentne, emtricitabin ili tenofovirdizoproksil.
English: Concomitant use of Ginkgo biloba extracts is not recommended (see section 4.4).
Croatian: Ne preporučuje se istodobna primjena ekstrakta Ginkgo bilobe (vidjeti dio 4.4).
English: Concomitant administration of simeprevir with efavirenz, a component of Atripla, resulted in significantly decreased plasma concentrations of simeprevir due to CYP3A induction by efavirenz, which may result in loss of therapeutic effect of simeprevir.
Croatian: sastojkom Atriple, rezultirala je značajno smanjenim koncentracijama simeprevira u plazmi zbog indukcije CYP3A efavirenzom, što može dovesti do gubitka terapijskog učinka simeprevira.
English: Simeprevir/Emtricitabine
Croatian: simeprevir/emtricitabin
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy (CART) and should be monitored according to standard practice.
Croatian: Bolesnici s otprije postojećim poremećajem funkcije jetre, uključujući kronični aktivni hepatitis, imaju povećanu učestalost abnormalnosti funkcije jetre tijekom kombinirane antiretrovirusne terapije (engl.
English: Sofosbuvir/velpatasvir and sofosbuvir/velpatasvir/voxilaprevir: Co-administration of Atripla and sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/voxilaprevir is not recommended (see section 4.4 and Table 1)
Croatian: Sofosbuvir/velpatasvir i sofosbuvir/velpatasvir/voksilaprevir: ne preporučuje se istodobna primjena Atriple i sofosbuvira/velpatasvira ili sofosbuvira/velpatasvira/voksilaprevira (vidjeti dio 4.4 i Tablicu 1)
English: - if you are allergic to efavirenz, emtricitabine, tenofovir, tenofovir disoproxil or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati Atriplu - ako ste alergični na efavirenz, emtricitabin, tenofovir, tenofovirdizoproksil ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.). - ako bolujete od teške bolesti jetre.
English: When the two strata were analysed separately, response rates in the stratum with prior PI-treatment were numerically lower for patients switched to Atripla [92.4% versus 94.0% for the PVR (sensitivity analysis) for Atripla and SBR patients respectively; a difference (95%CI) of -1.6% (-10.0%, 6.7%).
Croatian: Zasebna analiza dviju skupina pokazala je da su u skupini koja je prethodno liječena inhibitorima proteaze stope odgovora numerički manje u bolesnika koji su prešli na Atriplu [PVR (analiza osjetljivosti) od 92,4% u bolesnika koji su primali Atriplu u usporedbi s 94,0% u SBR bolesnika: razlika (95%CI) od -1,6% (-10,0%, 6,7%).
English: 0.5% (-7.0% to 9.3%)
Croatian: 0,5% (-7,0% do 9,3%)
English: Uncommon hepatitis acute
Croatian: Manje često akutni hepatitis
English: The mean (%CV) tenofovir exposure increased from 2,185 ng•h/ml (12%) in patients with normal renal function, to 3,064 ng•h/ml (30%), 6,009 ng•h/ml (42%) and 15,985 ng•h/ml (45%) in patients with mild, moderate and severe renal impairment, respectively.
Croatian: Srednja je vrijednost (% koeficijenta varijacije, CV) izloženosti tenofoviru porasla s 2185 (12%) ng•h/ml u ispitanika s normalnom funkcijom bubrega na 3064 (30%) ng•h/ml, 6009 (42%) ng•h/ml i 15 985 (45%) ng•h/ml, u bolesnika s blagim, umjerenim odnosno teškim oštećenjem funkcije bubrega.
English: Co-administration of Atripla and didanosine is not recommended (see section 4.4).
Croatian: Ne preporučuje se istodobna primjena Atriple i didanozina (vidjeti dio 4.4).
English: Exacerbations of hepatitis after discontinuation of treatment: In HIV infected patients co-infected with HBV, clinical and laboratory evidence of hepatitis may occur after discontinuation of treatment (see section 4.4).
Croatian: Egzacerbacije hepatitisa nakon prekida liječenja: U bolesnika s HIV-om koji su istodobno imali infekciju HBV-om, nakon prekida liječenja mogući su klinički i laboratorijski znakovi hepatitisa. (vidjeti dio 4.4).
English: Non-sustained convulsions were observed in some monkeys receiving efavirenz for ≥ 1 year, at doses yielding plasma AUC values 4- to 13-fold greater than those in humans given the recommended dose.
Croatian: Kod nekih majmuna, koji su primali efavirenz ≥ 1 godinu, opažene su prolazne konvulzije u slučaju davanja doza uz koje je dosegnuta 4 do 13 puta veća vrijednost AUC nego kod ljudi koji su primali preporučenu dozu.
English: Interaction not studied with efavirenz, emtricitabine, or tenofovir disoproxil.
Croatian: Nije ispitana interakcija s efavirenzom, emtricitabinom niti tenofovirdizoproksilom.
English: The administration of Atripla with food may increase efavirenz exposure (see section 5.2) and may lead to an increase in frequency of adverse reactions (see section 4.8).
Croatian: Uzimanje Atriple s hranom može povećati izloženost efavirenzu (vidjeti dio 5.2) te može dovesti do povećane učestalosti nuspojava (vidjeti dio 4.8).
English: Concomitant administration of Atripla and sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/ voxilaprevir is expected to decrease plasma concentrations of velpatasvir and voxilaprevir.
Croatian: Očekuje se da će istodobna primjena Atriple i sofosbuvira/velpatasvira ili sofosbuvira/velpatasvira/ voksilaprevira smanjiti koncentraciju velpatasvira i voksilaprevira u plazmi.
English: • back pain caused by kidney problems, including kidney failure.
Croatian: • bolovi u leđima prouzročeni problemima s bubrezima, uključujući zatajenje bubrega.
English: AUC: ↓ 43% (↓ 7 to ↓ 65) Cmax: ↔
Croatian: AUC: ↓ 43% (↓ 7 do ↓ 65) Cmax: ↔
English: Recommendation concerning co-administration with Atripla (efavirenz 600 mg, emtricitabine 200 mg, tenofovir disoproxil 245 mg)
Croatian: Preporuka za istodobnu primjenu s Atriplom (efavirenz 600 mg, emtricitabin 200 mg, tenofovirdizoproksil 245 mg)
English: AUC: ↓ 31% (↓ 8 to ↓ 47) Cmin: ↓ 40%
Croatian: AUC: ↓ 31% (↓ 8 do ↓ 47) Cmin: ↓ 40%
English: Uncommon hypersensitivity
Croatian: Manje često preosjetljivost
English: Atovaquone:
Croatian: atovakvon:
English: Atripla can reduce the amount of itraconazole or posaconazole in your blood.
Croatian: Atripla može smanjiti količinu itrakonazola ili posakonazola u krvi.
English: Reference: single dose of a 600 mg efavirenz tablet, 200 mg emtricitabine capsule and 300 mg tenofovir disoproxil tablet taken under fasted conditions.
Croatian: Referenca: jedna doza tablete od 600 mg efavirenza, kapsule od 200 mg emtricitabina i tablete od 300 mg tenofovirdizoproksila uzeta natašte
English: The daily dose of rifabutin should be increased by 50% when given with Atripla.
Croatian: Kada se rifabutin primjenjuje zajedno s Atriplom, njegova se dnevna doza treba povećati za 50%.
English: Morning Cmin: ↑ 42% (↑ 9 to ↑ 86) Evening Cmin: ↑ 24% (↑ 3 to ↑ 50)
Croatian: Cmin ujutro: ↑ 42% (↑ 9 do ↑ 86) Cmin navečer: ↑ 24% (↑ 3 do ↑ 50)
English: They usually begin during the first one or two days of efavirenz therapy and generally resolve after the first two to four weeks.
Croatian: Simptomi obično započinju tijekom prvog dana ili prva dva dana terapije efavirenzom i uglavnom nestaju nakon prva dva do četiri tjedna.
English: In patients treated with other medicinal products associated with liver toxicity, monitoring of liver enzymes is also recommended.
Croatian: Praćenje jetrenih enzima preporučuje se i u bolesnika koji primaju druge lijekove uz koje je vezana toksičnost za jetru.
English: Uncommon anaemia1
Croatian: Manje često anemija1
English: Emtricitabine and tenofovir are phosphorylated by cellular enzymes to form emtricitabine triphosphate and tenofovir diphosphate, respectively.
Croatian: Stanični enzimi fosforiliraju emtricitabin i tenofovir u emtricitabin trifosfat odnosno tenofovir difosfat.
English: -0.5% (-7.6% to 7.9%)
Croatian: -0,5% (-7,6% do 7,9%)
English: Hydroxybupropion:
Croatian: hidroksibupropion:
English: Atripla is not recommended for patients with moderate or severe renal impairment (creatinine clearance (CrCl) < 50 ml/min).
Croatian: Ne preporučuje se davanje Atriple bolesnicima s umjerenim ili teškim oštećenjem funkcije bubrega (klirens kreatinina (CrCl) < 50 ml/min).
English: AUC: ↔ Cmax: ↔ C24h: ↔
Croatian: emtricitabin: AUC: ↔ Cmax: ↔ C24h: ↔
English: For co-administration of efavirenz with low-dose ritonavir in combination with a protease inhibitor, see section on ritonavir above.
Croatian: Podatke o istodobnoj primjeni efavirenza s niskom dozom ritonavira u kombinaciji s inhibitorom proteaze potražite u odjeljku za ritonavir iznad.
English: - Once you start taking Atripla, look out for: - signs of dizziness, difficulty sleeping, drowsiness, difficulty concentrating or abnormal dreaming.
Croatian: pojava omaglice, otežanog spavanja, omamljenosti, problema u koncentraciji ili nenormalnih snova.
English: (CYP3A4 induction) Rash developed in 46% of uninfected volunteers receiving efavirenz and clarithromycin.
Croatian: U 46% neinficiranih dobrovoljaca koji su primali efavirenz i klaritromicin pojavio se osip.
English: IMMUNOSUPPRESSANTS Immunosuppressants metabolised by CYP3A4 (e.g. cyclosporine, tacrolimus, sirolimus)/Efavirenz
Croatian: Imunosupresivi koji se metaboliziraju enzimom CYP3A4 (npr. ciklosporin, takrolimus,
English: 4-hydroxy atorvastatin:
Croatian: 4-hidroksiatorvastatin:
English: Raltegravir/Tenofovir disoproxil (400 mg b.i.d./-)
Croatian: raltegravir/tenofovirdizoproksil (400 mg b.i.d./-)
English: - You must remain under the care of your doctor while taking Atripla.
Croatian: - Tijekom uzimanja Atriple morate biti pod nadzorom liječnika.
English: - if you are currently taking any of the following medicines (see also “Other Medicines and Atripla”): - astemizole or terfenadine (used to treat hay fever or other allergies) - bepridil (used to treat heart disease) - cisapride (used to treat heartburn) - elbasvir/grazoprevir (used to treat hepatitis C) - ergot alkaloids (for example, ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (used to treat migraines and cluster headaches) - midazolam or triazolam (used to help you sleep)
Croatian: - ako trenutno uzimate bilo koji od sljedećih lijekova (pogledajte također „Drugi lijekovi i Atripla“): astemizol ili terfenadin (koriste se za liječenje peludne groznice i drugih alergija) bepridil (koristi se za liječenje bolesti srca) cisaprid (koristi se za liječenje žgaravice) elbasvir/grazoprevir (koristi se za liječenje hepatitisa C) ergot alkaloide (na primjer, ergotamin, dihidroergotamin, ergonovin i metilergonovin) (koriste se za liječenje migrena i klasterskih glavobolja) midazolam ili triazolam (koriste se za lakše spavanje) pimozid, imipramin, amitriptilin ili klomipramin (koristi se za liječenje određenih psihičkih stanja) gospinu travu (Hypericum perforatum) (biljni pripravak za liječenje depresije i anksioznosti) vorikonazol (koristi se za liječenje gljivičnih infekcija) flekainid, metoprolol (koristi se za liječenje nepravilnih srčanih otkucaja) određene antibiotike (makrolidi, fluorokinoloni, imidazol) lijekove za liječenje gljivičnih infekcija koji sadrže triazol određene lijekove za liječenje malarije metadon (koristi se za liječenje ovisnosti o opioidima).
English: The pharmacokinetics of efavirenz, emtricitabine and tenofovir disoproxil after co-administration of the separate pharmaceutical forms or as Atripla have not been studied in HIV infected patients with renal impairment.
Croatian: Farmakokinetika efavirenza, emtricitabina i tenofovirdizoproksila nakon njihove istodobne primjene kao zasebnih farmaceutskih oblika ili davanja u obliku Atriple nije istraživana u bolesnika inficiranim virusom HIV-a s oštećenjem funkcije bubrega.
English: Discontinuation of Atripla therapy in patients co-infected with HIV and HBV may be associated with severe acute exacerbations of hepatitis (see section 4.4).
Croatian: Prekid terapije Atriplom u bolesnika istodobno inficiranih HIV-om i HBV-om može biti povezan s teškim akutnim egzacerbacijama hepatitisa (vidjeti dio 4.4).
English: Atripla is a fixed-dose combination of efavirenz, emtricitabine and tenofovir disoproxil fumarate.
Croatian: Atripla je kombinacija fiksne doze efavirenza, emtricitabina i tenofovirdizoproksilfumarata.
English: 4 This adverse reaction was identified through post-marketing surveillance for either efavirenz, emtricitabine or tenofovir disoproxil.
Croatian: Ova je nuspojava uočena tijekom praćenja koje je nakon stavljanja u promet provedeno za efavirenz, emtricitabin ili tenofovirdizoproksil.
English: Itraconazole:
Croatian: itrakonazol:
English: 2-hydroxy atorvastatin:
Croatian: 2-hidroksiatorvastatin:
English: Dose adjustments of diltiazem when coadministered with Atripla should be guided by clinical response (refer to the Summary of Product Characteristics for diltiazem).
Croatian: Podešavanja doze diltiazema kada se primjenjuje istodobno s Atriplom treba usklađivati s kliničkim odgovorom (pogledajte sažetak opisa svojstava lijeka za diltiazem).
English: Emtricitabine displayed antiviral activity against HIV-1 clades A, B, C, D, E, F, and G. Tenofovir displayed antiviral activity against HIV-1 clades A, B, C, D, E, F, G, and O. Both emtricitabine and tenofovir showed strain specific activity against HIV-2 and antiviral activity against HBV.
Croatian: Tenofovir je pokazao antivirusnu aktivnost protiv skupina A, B, C, D, E, F, G i O virusa HIV-1.
English: Convulsions have been observed in patients receiving efavirenz, generally in the presence of a known medical history of seizures.
Croatian: U bolesnika koji primaju efavirenz uočene su konvulzije, obično uz pozitivnu anamnezu napadaja.
English: Raltegravir/Emtricitabine
Croatian: raltegravir/emtricitabin
English: Insufficient data are available to make a dosing recommendation for indinavir when dosed with Atripla.
Croatian: Nije dostupno dovoljno podataka za određivanje preporuke doze za indinavir ako se on dozira s Atriplom.
English: Swallow Atripla whole with water.
Croatian: Progutajte cijelu tabletu Atriple s vodom.