FrancophonIA/ELRC3.0 huggingface dataset:
English: Lamivudine and tenofovir disoproxil are already available in the European Union: lamivudine has been authorised since 1996 and tenofovir disoproxil since 2002.
Croatian: Lamivudin i tenofovirdizoproksil već su dostupni u Europskoj uniji: lamivudin je odobren od 1996., a tenofovirdizoproksil od 2002.
English: What is Delstrigo and what is it used for?
Croatian: Što je Delstrigo i za što se primjenjuje?
English: Why is Delstrigo authorised in the EU?
Croatian: Zašto je Delstrigo odobren u EU-u?
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Delstrigo have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Delstrigo nalaze se u sažetku opisa svojstava i u uputi o lijeku.
English: In addition, Delstrigo's side effects are mostly mild.
Croatian: Osim toga, nuspojave lijeka Delstrigo uglavnom su blage.
English: It can only be obtained with a prescription and treatment should be started by a doctor who has experience in the management of HIV infection.
Croatian: Izdaje se samo na liječnički recept te liječenje mora započeti liječnik s iskustvom u upravljanju infekcijom HIV-om.
English: The European Medicines Agency therefore decided that Delstrigo's benefits are greater than its risks and it can be authorised for use in the EU.
Croatian: Europska agencija za lijekove zaključila je da koristi od lijeka Delstrigo nadmašuju s njim povezane rizike te da lijek može biti odobren za primjenu u Europskoj uniji.
English: As for all medicines, data on the use of Delstrigo are continuously monitored.
Croatian: Kao i za sve lijekove, podatci o primjeni lijeka Delstrigo kontinuirano se prate.
English: Delstrigo is available as tablets, each containing doravirine 100 mg, lamivudine 300 mg and tenofovir disoproxil 245 mg.
Croatian: Delstrigo je dostupan u obliku tableta, od kojih svaka sadrži 100 mg doravirina, 300 mg lamivudina i 245 mg tenofovirdizoproksila.
English: The most common side effects with doravirine (which may affect up to 1 in 10 people) are nausea (feeling sick) and headache.
Croatian: Najčešće nuspojave lijeka Delstrigo (koje se mogu javiti u do 1 na 10 osoba) su mučnina (slabost), proljev i glavobolja.
English: Delstrigo is an antiviral medicine used to treat adults infected with human immunodeficiency virus type 1 (HIV-1), a virus that causes acquired immune deficiency syndrome (AIDS).
Croatian: Delstrigo je antivirusni lijek koji se primjenjuje za liječenje odraslih osoba zaraženih virusom humane imunodeficijencije tipa 1 (HIV-1), virusom koji uzrokuje sindrom stečene imunodeficijencije (AIDS).
English: What are the risks associated with Delstrigo?
Croatian: Koji su rizici povezani s lijekom Delstrigo?
English: For more information about using Delstrigo, see the package leaflet or contact your doctor or pharmacist.
Croatian: Više informacija o primjeni lijeka Delstrigo pročitajte u uputi o lijeku, odnosno obratite se liječniku ili ljekarniku.
English: It does not cure HIV infection or AIDS but it holds off the damage to the immune system and the development of infections and diseases associated with AIDS.
Croatian: Delstrigo ne liječi infekciju HIV-om ni AIDS, ali privremeno zaustavlja narušavanje imunosnog sustava i razvoj infekcija i bolesti povezanih s AIDS-om.
English: Tenofovir disoproxil is a ‘prodrug' of tenofovir, meaning that it is converted in the body to the active substance tenofovir.
Croatian: Tenofovirdizoproksil je „prolijek” tenofovira, što znači da se u tijelu pretvara u djelatnu tvar tenofovir.
English: An overview of Delstrigo and why it is authorised in the EU
Croatian: Pregled informacija o lijeku Delstrigo i zašto je odobren u EU-u
English: Delstrigo (doravirine / lamivudine / tenofovir disoproxil) EMA/873969/2018
Croatian: Delstrigo (doravirin/lamivudin/tenofovirdizoproksil) EMA/661904/2018
English: The medicine is not suitable for patients who are infected with HIV that is resistant to lamivudine, tenofovir disoproxil or to medicines in the same class as doravirine (non-nucleoside reverse transcriptase inhibitors or NNRTIs).
Croatian: Lijek nije prikladan za bolesnike zaražene virusom HIV koji je otporan na lamivudin, tenofovirdizoproksil ili lijekove iz istog razreda kao doravirin (nenukleozidni inhibitori reverzne transkriptaze, NNRTI).
English: The three active substances in Delstrigo, doravirine, lamivudine and tenofovir disoproxil, block the activity of reverse transcriptase, an enzyme that allows HIV to reproduce itself in the cells it has infected.
Croatian: Sve tri djelatne tvari lijeka Delstrigo, doravirin, lamivudin i tenofovirdizoproksil, blokiraju djelovanje reverzne transkriptaze, enzima koji HIV-u omogućuje reprodukciju u zaraženim stanicama.
English: Delstrigo was as effective at keeping HIV infection under control as a similar HIV combination treatment in a main study involving patients with HIV infection who had not been treated before.
Croatian: Delstrigo se pokazao jednako djelotvornim pri kontroliranju infekcije HIV-om kao i slična kombinirana terapija protiv HIV-a u glavnom ispitivanju koje je uključivalo bolesnike s infekcijom HIV-om koji prethodno nisu bili liječeni.
English: Delstrigo is as effective at keeping HIV infection under control as similar HIV combination treatments.
Croatian: Delstrigo se pokazao jednako djelotvornim pri kontroliranju infekcije HIV-om kao i slične kombinirane terapije.
English: Delstrigo (doravirine / lamivudine / tenofovir disoproxil)
Croatian: Delstrigo (doravirin/lamivudin/tenofovirdizoproksil)
English: Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI).
Croatian: Doravirin je nenukleozidni inhibitor reverzne transkriptaze (NNRTI)(NNRTI), a lamivudin nukleozidni inhibitor reverzne transkriptaze(NRTI).
English: What benefits of Delstrigo have been shown in studies?
Croatian: Koje su koristi od lijeka Delstrigo utvrđene u ispitivanjima?
English: Delstrigo contains the active substances doravirine, lamivudine and tenofovir disoproxil.
Croatian: Delstrigo sadrži djelatne tvari doravirin, lamivudin i tenofovirdizoproksil.
English: How does Delstrigo work?
Croatian: Kako djeluje Delstrigo?
English: For the full list of side effects and restrictions with Delstrigo, see the package leaflet.
Croatian: Potpuni popis nuspojava i ograničenja pri primjeni lijeka Delstrigo potražite u uputi o lijeku.
English: How is Delstrigo used?
Croatian: Kako se Delstrigo primjenjuje?
English: (Invented) name Strength Pharmaceutical Form Route of Administration Packaging
Croatian: Doza Farmaceutski oblik
English: How many tablets should you take
Croatian: Koliko tableta trebate uzeti
English: Both doses should not be taken at the same time.
Croatian: Ne smiju se uzeti obje doze u isto vrijeme.
English: ● If you do plan to go into the sun:
Croatian: • Ako planirate izlaziti na sunce:
English: ● The other ingredients are:
Croatian: • Drugi sastojci su:
English: Do not take Zelboraf:
Croatian: Nemojte uzimati Zelboraf:
English: This is very important, as using more than one medicine at the same time can strengthen or weaken the effect of medicines.
Croatian: Ovo je jako važno jer uzimanje više od jednog lijeka u isto vrijeme može pojačati ili oslabiti učinak lijekova.
English: In particular, tell your doctor if you are taking:
Croatian: Naročito recite liječniku ako uzimate:
English: ● Do not take Zelboraf regularly on an empty stomach.
Croatian: • Zelboraf nemojte redovito uzimati na prazan želudac.
English: This change may have led to the development of melanoma.
Croatian: Moguće je da je ta promjena izazvala razvoj melanoma.
English: The maximum tolerated dose could not be determined.
Croatian: Maksimalna podnošljiva doza nije se mogla utvrditi.
English: A total of 146 patients were enrolled.
Croatian: U ispitivanje je bilo uključeno ukupno 146 bolesnika.
English: Stage IIIc/M1A/M1B
Croatian: Stadij IIIc/M1A/M1B
English: It is unclear whether this is a gender or a body size effect.
Croatian: Nije jasno radi li se o utjecaju spola ili veličine tijela.
English: Treatment not recommended.
Croatian: Liječenje se ne preporučuje.
English: Then take the next dose at the usual time.
Croatian: Zatim uzmite sljedeću dozu u uobičajeno vrijeme.
English: Tell your doctor if you are pregnant or planning to become pregnant.
Croatian: Recite liječniku ako ste trudni ili planirate trudnoću.
English: Date of latest renewal: 22 September 2016
Croatian: Datum posljednje obnove odobrenja: 22. rujna 2016.
English: 0 (not applicable)
Croatian: 0 (nije primjenjivo)
English: Currently available data are described in sections 4.8, 5.1, and 5.2, but no recommendation on a posology can be made.
Croatian: Trenutno dostupni podaci opisani su u dijelovima 4.8, 5.1 i 5.2, međutim nije moguće dati preporuku o doziranju.
English: Interrupt treatment until grade 0 - 1.
Croatian: Prekinuti liječenje dok se ne postigne stupanj 0 - 1.
English: Inhibitory Concentration 50 (nM)
Croatian: Inhibitorna koncentracija 50 (nM)
English: What Zelboraf contains
Croatian: Što Zelboraf sadrži
English: Injury, Poisoning, and Procedural Complications
Croatian: Ozljede, trovanja i proceduralne komplikacije
English: Checks of your skin before, during and after treatment
Croatian: Pregledi kože prije, tijekom i nakon liječenja
English: Do not use any more Zelboraf until you have spoken to a doctor.
Croatian: Nemojte više uzimati Zelboraf dok ne porazgovarate s liječnikom.
English: Then take 4 tablets in the evening.
Croatian: Zatim uzmite 4 tablete navečer.
English: Zelboraf is not recommended for children and adolescents.
Croatian: Zelboraf se ne preporučuje djeci i adolescentima.
English: ● Take 4 tablets in the morning.
Croatian: • Uzmite 4 tablete ujutro.
English: Before starting treatment, tell your doctor if you are taking, have recently taken or might use any other medicines (including those you have bought for yourself from a pharmacy, supermarket or health store).
Croatian: Prije započinjanja liječenja obavijestite svog liječnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove (uključujući i one koje ste sami kupili u ljekarni, supermarketu ili specijaliziranoj prodavaonici).
English: All percentages are expressed as cases out of total patients exposed to each medicinal product.
Croatian: Svi su postoci izraženi kao slučajevi u ukupnom broju bolesnika izloženih svakom od lijekova.
English: Tell your doctor immediately if you experience any of the following symptoms:
Croatian: Odmah obavijestite liječnika ako primijetite bilo koji od sljedećih simptoma:
English: During treatment, avoid exposing your skin to direct sunlight.
Croatian: Tijekom liječenja, izbjegavajte izlaganje svoje kože izravnom sunčevom svjetlu.
English: What Zelboraf is and what it is used for
Croatian: Što je Zelboraf i za što se koristi
English: • Very common: GGT
Croatian: • Vrlo često: GGT
English: ● Swallow the tablets whole with a glass of water.
Croatian: • Tablete progutajte cijele, s čašom vode.
English: ● If your doctor finds this type of skin cancer, he or she will treat it or send you to another doctor for treatment.
Croatian: • Ako Vaš liječnik otkrije ovu vrstu raka kože, liječit će ga, ili će Vas uputiti na liječenje drugom liječniku.
English: In addition ECG monitoring every month during the first three months is recommended.
Croatian: Osim toga, preporučuje se svaki mjesec kontrolirati EKG u prva tri mjeseca.
English: • ≥ 5x ULN ALT
Croatian: • ≥ 5x GGN ALT
English: What you need to know before you take Zelboraf
Croatian: Što morate znati prije nego počnete uzimati Zelboraf
English: ● wear clothing which protects your skin, including your head and face, arms and legs;
Croatian: • odjenite odjeću koja će zaštititi kožu, uključujući glavu i lice, ruke i noge;
English: ● Loss of appetite
Croatian: • gubitak apetita
English: However, the differences in exposure are not large enough to warrant dose adjustment based on body size or gender.
Croatian: Ipak, razlike u izloženosti nisu dovoljno velike da bi bilo opravdano prilagođavati dozu na temelju veličine tijela ili spola.
English: It is used to treat adult patients with melanoma that has spread to other parts of the body or cannot be removed by surgery.
Croatian: Koristi se za liječenje odraslih bolesnika s melanomom koji se proširio u druge dijelove tijela ili se ne može kirurški odstraniti.
English: If necessary, your doctor may decide to interrupt your treatment temporarily or stop it altogether.
Croatian: Ako bude potrebno, liječnik može odlučiti privremeno prekinuti liječenje, ili ga u potpunosti obustaviti.
English: Total n = 146
Croatian: Ukupno n = 146
English: The tablets are to be swallowed whole with water.
Croatian: Tablete je potrebno progutati cijele, s vodom.
English: Please talk to your doctor as soon as possible if you notice any changes in your skin.
Croatian: Molimo, što prije se obratite svom liječniku ako primijetite bilo kakve promjene na koži.
English: Like all medicines, Zelboraf can cause side effects, although not everybody gets them.
Croatian: Kao i svi lijekovi, Zelboraf može uzrokovati nuspojave iako se one neće javiti kod svakoga.
English: Warnings and precautions Talk to your doctor before taking Zelboraf.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku prije nego uzmete Zelboraf.
English: Please tell your doctor if you are taking an oral contraceptive.
Croatian: Recite liječniku ako uzimate neki oralni kontraceptiv.
English: ● The recommended dose is 4 tablets twice a day (a total of 8 tablets).
Croatian: • Preporučena doza je 4 tablete dvaput na dan (ukupno 8 tableta).
English: Sun protection
Croatian: Zaštita od sunca
English: Vemurafenib exhibits high inter-patient variability.
Croatian: Vemurafenib pokazuje veliku varijabilnost između bolesnika.
English: Other medicines and Zelboraf
Croatian: Drugi lijekovi i Zelboraf
English: • ≥ 2x ULN ALP (without other cause for ALP elevation)
Croatian: • ≥ 2x GGN ALP (bez drugog uzroka povećanja ALP-a)
English: Post-hoc survival analyses were undertaken thereafter as described in table 7.
Croatian: Nakon toga su provedene post-hoc analize, kako je prikazano u tablici 7.
English: ● Medicines that are known to affect the way your heart beats:
Croatian: • Lijekove za koje je poznato da utječu na rad srca:
English: PFS - overall Median (months)e
Croatian: PFS - ukupno Medijan (mjeseci)e
English: ● Use an appropriate method of contraception during your treatment and for at least 6 months after the end of your treatment.
Croatian: • Koristite odgovarajuću metodu kontracepcije tijekom liječenja i još najmanje 6 mjeseci nakon završetka liječenja.
English: Vemurafenib (%) Dacarbazine (%)
Croatian: Vemurafenib (%) Dakarbazin (%)
English: Vemurafenib may be taken with or without food, but consistent intake of both daily doses on an empty stomach should be avoided (see section 5.2).
Croatian: Vemurafenib se može uzimati s hranom ili bez nje, no treba izbjegavati stalno uzimanje obje dnevne doze na prazan želudac (vidjeti dio 5.2).
English: ● Additionally, your doctor needs to inspect your head, your neck, your mouth, your lymph glands and you will undergo CT scans regularly.
Croatian: • Osim toga, liječnik Vam mora pregledati glavu, vrat, usnu šupljinu i limfne čvorove, a redovito ćete ići na snimanja CT-om.
English: All patients should be advised to avoid sun exposure while taking vemurafenib.
Croatian: Svim bolesnicima potrebno je savjetovati da izbjegavaju izlaganje suncu dok uzimaju vemurafenib.
English: LDH normal
Croatian: Normalna LDH
English: Table 8 shows the treatment effect for all pre-specified stratification variables which are established as prognostic factors.
Croatian: Tablica 8 prikazuje učinak liječenja za sve prethodno određene stratifikacijske varijable koje su utvrđene kao prognostički čimbenici.
English: The median age was 52 years with 19% of patients being older than 65 years.
Croatian: Medijan dobi iznosio je 52 godine, a 19% bolesnika bilo je starije od 65 godina.
English: ● This will help to protect you against sunburn.
Croatian: • To će pomoći da se zaštitite od sunčanih opeklina.
English: ● Zelboraf is not recommended for use during pregnancy unless your doctor considers that the benefit for the mother outweighs the risk for the baby.
Croatian: • Zelboraf se ne preporučuje za primjenu u trudnoći osim ako Vaš liječnik ne smatra da dobrobit liječenja za majku nadilazi rizike za dijete.
English: They should not be chewed or crushed.
Croatian: Ne smiju se žvakati niti drobiti.
English: Temporarily interrupt treatment until QTc decreases below 500 ms.
Croatian: Privremeno prekinuti liječenje dok se QTc ne spusti ispod 500 ms.
English: It is currently unknown whether vemurafenib is a substrate also to other transport proteins.
Croatian: Zasad nije poznato je li vemurafenib supstrat i za druge transportne proteine.
English: Upon Data Safety Monitoring Board (DSMB) recommendation, those results were released in January 2011 and the study was modified to permit dacarbazine patients to cross over to receive vemurafenib.
Croatian: Prema preporuci Odbora za nadzor podataka o sigurnosti primjene (Data Safety Monitoring Board, DSMB) ti su rezultati objavljeni u siječnju 2011. godine i ispitivanje je modificirano kako bi se bolesnicima koji su primali dakarbazin omogućilo da prijeđu na liječenje vemurafenibom.
English: It is highly bound to human plasma proteins in vitro (>99%).
Croatian: Vemurafenib se u velikoj mjeri veže za proteine u ljudskoj plazmi in vitro (> 99%).
English: Although metabolism does not appear to result in a relevant amount of metabolites in plasma, the importance of metabolism for excretion cannot be excluded.
Croatian: Iako metabolizam ne rezultira značajnom količinom metabolita u plazmi, ne može se isključiti važnost metabolizma za izlučivanje.
English: Discontinue permanently.
Croatian: Trajno obustaviti liječenje.
English: ● If you are taking Zelboraf, you may become more sensitive to sunlight and get sunburns that can be severe.
Croatian: • Ako uzimate Zelboraf, možete postati osjetljiviji na sunce i zadobiti opekline od sunca koje mogu biti ozbiljne.
English: ● A medicine called ipilimumab, another medicine for the treatment of melanoma.
Croatian: • Lijek koji se zove ipilimumab, drugi lijek za liječenje melanoma.
English: ● If you are allergic to vemurafenib or any of the other ingredients of this medicine (listed in section 6 of this leaflet).
Croatian: • ako ste alergični (preosjetljivi) na vemurafenib ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: The majority of vemurafenib-related material (94%) was recovered in faeces, and <1% in urine.
Croatian: Većina materijala koji potječe od vemurafeniba (94%) pronađe se u fecesu, a < 1% u urinu.
English: ● Bell's palsy (a form of facial paralysis that is often reversible)
Croatian: • Bellova paraliza (oblik paralize lica koji je često reverzibilan)
English: No studies were performed regarding pre- and postnatal development.
Croatian: Nisu provedena ispitivanja prenatalnog i postnatalnog razvoja.
English: Although transient tumour regressions were seen, the best overall response rate (BORR) was 0% (95% CI: 0%, 46%) based on confirmed responses.
Croatian: Iako su primijećeni slučajevi prolazne regresije tumora, stopa najboljeg ukupnog odgovora (BORR) iznosila je 0% (95% CI: 0%, 46%) na temelju potvrđenih odgovora.
English: Cohort 1 No previous treatment n = 90
Croatian: 1. kohorta Bez prethodnog liječenja n = 90
English: If you stop taking Zelboraf
Croatian: Ako prestanete uzimati Zelboraf
English: BORR extracranial n (%)a
Croatian: ekstrakranijalni, n (%)a
English: Hazard Ratio 95% Confidence Interval
Croatian: Omjer hazarda Interval pouzdanosti 95%
English: It can only be used in patients whose cancer has a change (mutation) in the “BRAF” gene.
Croatian: Smije se koristiti samo u bolesnika čiji tumor ima promjenu (mutaciju) gena "BRAF".
English: ● Tell your doctor if you have a heart disorder, such as an alteration of the electrical activity of your heart called “QT prolongation”.
Croatian: • Obavijestite liječnika ako imate neki srčani poremećaj, poput promjene električne aktivnosti srca koja se zove "produljenje QT-intervala".
English: The possible effect of vemurafenib on other transporters is currently unknown.
Croatian: Mogući učinak vemurafeniba na druge prijenosnike zasad nije poznat.
English: Safety and efficacy data from pivotal studies were collected from patients taking vemurafenib with or without food.
Croatian: Podaci o sigurnosti i djelotvornosti iz pivotalnih ispitivanja prikupljeni su u bolesnika koji su uzimali vemurafenim s hranom ili bez nje.
English: ● If you have any further questions, ask your doctor.
Croatian: • Ako imate dodatnih pitanja, obratite se liječniku.
English: The study included two simultaneously enrolling cohorts:
Croatian: U ispitivanju su sudjelovale dvije kohorte u koje su se bolesnici uključivali istovremeno:
English: Thus close monitoring is warranted especially after the first few weeks of treatment as accumulation may occur over an extended period of time (several weeks).
Croatian: Savjetuje se poman nadzor, osobito nakon prvih nekoliko tjedana liječenja, jer može doći do nakupljanja lijeka tijekom duljeg razdoblja (više tjedana).
English: ● Tell your doctor if you observe any unusual thickening of the palms of your hands accompanied by tightening of the fingers inward or any unusual thickening of the soles of your feet which may be painful.
Croatian: • Obavijestite liječnika ako primijetite bilo kakvo neuobičajeno zadebljanje dlanova praćeno zatezanjem prstiju prema unutra ili bilo kakvo neuobičajeno zadebljanje tabana koje može biti bolno.
English: Patients should be instructed to inform their physicians upon the occurrence of any skin changes.
Croatian: Bolesnike je potrebno savjetovati da svog liječnika obavijeste o svakoj promjeni na koži.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu .
English: The median Tmax was increased from 4 to 7.5 hours when a single vemurafenib dose was taken with food.
Croatian: Medijan Tmax produljio se sa 4 na 7,5 sati kada je jedna doza vemurafeniba uzeta s hranom.
English: The combination of this medicine with Zelboraf is not recommended due to increased toxicity to the liver.
Croatian: Kombinacija ovog lijeka s lijekom Zelboraf se ne preporučuje zbog povećanog štetnog djelovanja na jetru.
English: If you forget to take Zelboraf
Croatian: Ako ste zaboravili uzeti Zelboraf
English: Zelboraf may decrease the efficacy of some oral contraceptives.
Croatian: Zelboraf može umanjiti djelotvornost nekih oralnih kontraceptiva.
English: ● In case of vomiting, continue to take Zelboraf as usual and do not take an additional dose.
Croatian: • U slučaju da povratite, nastavite uzimati Zelboraf na uobičajen način i nemojte uzeti dodatnu dozu.
English: ● Change in liver laboratory tests results or liver injury, including severe liver injury where liver is injured to the extent that it is not able to fully perform its function
Croatian: • promjene rezultata laboratorijskih testova jetrene funkcije ili oštećenje tkiva jetre, uključujući teška oštećenja tkiva jetre gdje je jetra oštećena do te mjere da nije u mogućnosti u potpunosti obavljati svoju funkciju.
English: Always take Zelboraf exactly as your doctor has told you.
Croatian: Uvijek uzmite Zelboraf točno onako kako Vam je rekao Vaš liječnik.
English: Stratification variable
Croatian: Stratifikacijska varijabla
English: If you take more Zelboraf than you should, talk to your doctor immediately.
Croatian: Ako ste uzeli više lijeka Zelboraf nego što ste trebali, odmah se obratite svom liječniku.
English: Many anticancer medicinal products are substrates of BCRP and therefore there is a theoretical risk for an interaction with vemurafenib.
Croatian: Mnogi su lijekovi za liječenje raka supstrati BCRP-a pa postoji teoretski rizik od interakcije s vemurafenibom.