FrancophonIA/ELRC3.0 huggingface dataset:
English: PREZISTA must always be given orally with cobicistat or low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products.
Croatian: PREZISTA se uvijek mora primjenjivati peroralno s kobicistatom ili niskom dozom ritonavira kao farmakokinetičkim pojačivačem i u kombinaciji s drugim antiretrovirusnim lijekovima.
English: Boosted PREZISTA and raltegravir can be used without dose adjustments.
Croatian: Pojačana PREZISTA i raltegravir mogu se primijeniti bez prilagodbe doze.
English: 60 tablets in a plastic bottle.
Croatian: Plastična bočica sa 60 tableta.
English: Dose for adults who have taken antiretroviral medicines before (your doctor will determine this) The dose is either: - 800 milligram PREZISTA (2 tablets containing 400 milligram of PREZISTA or 1 tablet containing 800 milligram of PREZISTA) together with 150 milligram cobicistat or 100 milligram ritonavir once daily.
Croatian: Doza za odrasle koji su već prije uzimali antiretrovirusne lijekove (to će odrediti Vaš liječnik) Doza može biti: - 800 miligrama lijeka PREZISTA (2 tablete koje sadrže 400 miligrama lijeka PREZISTA ili 1 tableta koja sadrži 800 miligrama lijeka PREZISTA) zajedno sa 150 miligrama kobicistata ili 100 miligrama ritonavira jedanput na dan.
English: Shake bottle vigorously before use.
Croatian: Prije primjene snažno protresite bočicu.
English: In women receiving darunavir/cobicistat during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC24h and Cmin were 49%, 56% and 92% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC24h and Cmin values were 37%, 50% and 89% lower, respectively, as compared with postpartum.
Croatian: U žena koje uzimaju darunavir/kobicistat tijekom drugog tromjesečja trudnoće, srednje intra-individualne vrijednosti Cmax, AUC24h i Cmin za ukupni darunavir bile su 49%, 56% odnosno 92% niže, u usporedbi s postpartalnim razdobljem; tijekom trećeg tromjesečja trudnoće, vrijednosti Cmax, AUC24h i Cmin za ukupni darunavir bile su 37%, 50% i 89% niže, u usporedbi s postpartalnim razdobljem.
English: 800 mg PREZISTA/100 mg ritonavir once daily ritonavir oral solution: 80 mg/ml
Croatian: 800 mg PREZISTA/100 mg ritonavir jedanput na dan ritonavir oralna otopina: 80 mg/ml
English: PREZISTA/ ritonavir 800/100 mg once daily N=343
Croatian: PREZISTA/ ritonavir 800/100 mg jedanput na dan n=343
English: Co-administration of PREZISTA co-administered with cobicistat and bosentan is not recommended.
Croatian: Primjena lijeka PREZISTA istodobno primijenjenog s kobicistatom i bosentanom se ne preporučuje.
English: Number of subjects with virologic failure and paired baseline/endpoint genotypes, developing mutations b at endpoint, n/N Primary (major) PI mutations PI RAMs Number of subjects with virologic failure and paired baseline/endpoint phenotypes, showing loss of susceptibility to PIs at endpoint compared to baseline, n/N PI
Croatian: Broj ispitanika s virološkim neuspjehom i odgovarajući fenotip na početku/na kraju liječenja koji pokazuju gubitak osjetljivosti na IP na ishodu u usporedbi s onim na početku liječenja, n/N Inhibitori proteaze (IP) darunavir amprenavir atazanavir indinavir lopinavir sakvinavir tipranavir
English: OUTER CARTON FOR ORAL SUSPENSION
Croatian: KUTIJA ZA ORALNU SUSPENZIJU
English: ritonavir oral solution: 80 milligram per milliliter
Croatian: oralna otopina ritonavira: 80 miligrama po mililitru
English: In women receiving darunavir/ritonavir 800/100 mg once daily during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC24h and Cmin were 33%, 31% and 30% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC24h and Cmin values were 29%, 32% and 50% lower, respectively, as compared with postpartum.
Croatian: U žena koje su primale darunavir/ritonavir 800/100 mg jedanput dnevno tijekom drugog tromjesečja trudnoće, srednje intra-individualne vrijednosti za ukupni darunavir Cmax, AUC24h i Cmin bile su 33%, 31% odnosno 30% niže, uspoređujući s postpartalnim razdobljem; tijekom trećeg tromjesečja trudnoće, vrijednosti za ukupni darunavir Cmax, AUC24h i Cmin bile su 29%, 32% odnosno 50% niže, uspoređujući s postpartalnim razdobljem.
English: Clinical monitoring is recommended when co-administering boosted PREZISTA with these analgesics.
Croatian: Preporučeno je kliničko praćenje kada se istodobno primjenjuju ovi analgetici s pojačanom PREZISTOM.
English: Each ml of oral suspension contains 100 mg of darunavir (as ethanolate).
Croatian: Jedan ml oralne suspenzije sadrži 100 mg darunavira (u obliku darunaviretanolata).
English: The combination of rifampicin and boosted PREZISTA is contraindicated (see section 4.3).
Croatian: Kombinacija rifampicina i pojačane PREZISTE je kontraindicirana (vidjeti dio 4.3).
English: 600 mg (6 ml) PREZISTA/100 mg (1.2 ml) ritonavir once daily
Croatian: 600 mg (6 ml) PREZISTA/100 mg (1,2 ml) ritonavir jedanput na dan
English: The combination of rifampicin and PREZISTA with concomitant low dose ritonavir is contraindicated (see section 4.3).
Croatian: Kombinacija rifampicina i lijeka PREZISTA primijenjenog istodobno s niskom dozom ritonavira je kontraindicirana (vidjeti dio 4.3).
English: Light orange oval shaped tablet of 19.1 mm, debossed with “400MG” on one side and “TMC” on the other side.
Croatian: Svijetlonarančasta ovalna tableta od 19,1 mm, s utisnutim „400MG“ na jednoj strani i „TMC“ na drugoj strani.
English: These active substances include e.g.: - alfuzosin - amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine - astemizole, terfenadine - colchicine when used in patients with renal and/or hepatic impairment (see section 4.5) - ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine) - elbasvir/grazoprevir - cisapride - dapoxetine - domperidone - naloxegol - lurasidone, pimozide, quetiapine, sertindole (see section 4.5) - triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
Croatian: Ti djelatne tvari, primjerice uključuju: - alfuzozin - amiodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin - astemizol, terfenadin - kolhicin kada se primjenjuje kod bolesnika s oštećenjem bubrega i/ili jetre (vidjeti dio 4.5) - ergot derivate (npr. dihidroergotamin, ergometrin, ergotamin, metilergonovin) - elbasvir/grazoprevir - cisaprid - dapoksetin - domperidon - naloksegol - lurasidon, pimozid, kvetiapin, sertindol (vidjeti dio 4.5) - triazolam, peroralno primijenjen midazolam (mjere opreza za parenteralnu primjenu midazolama vidjeti dio 4.5) - sildenafil - kada se primjenjuje za liječenje plućne arterijske hipertenzije, avanafil - simvastatin, lovastatin i lomitapid (vidjeti dio 4.5) - dabigatran, tikagrelor (vidjeti dio 4.5).
English: Concomitant use of boosted PREZISTA with lovastatin and simvastatin is therefore contraindicated (see section 4.3).
Croatian: Istodobna primjena pojačane PREZISTE s lovastatinom i simvastatinom je zbog toga kontraindicirana (vidjeti dio 4.3).
English: Patients co-infected with hepatitis B and/or hepatitis C virus Among 1,968 treatment-experienced patients receiving PREZISTA co-administered with ritonavir 600/100 mg twice daily, 236 patients were co-infected with hepatitis B or C. Co-infected patients were more likely to have baseline and treatment emergent hepatic transaminase elevations than those without chronic viral hepatitis (see section 4.4).
Croatian: Bolesnici istodobno inficirani virusom hepatitisa B i/ili hepatitisa C Od 1968 prethodno liječenih bolesnika, a primali su lijek PREZISTA primjenjen istodobno s ritonavirom od 600/100 mg dva puta na dan, 236 bolesnika bilo je istodobno inficirano hepatitisom B ili C.
English: The doctor will inform you on how many PREZISTA tablets and how much ritonavir (capsules, tablets or solution) the child must take.
Croatian: Liječnik će odrediti koliko tableta lijeka PREZISTA i koliko ritonavira (kapsula, tableta ili otopine) dijete mora uzimati.
English: PREZISTA/ ritonavir 600/100 mg twice daily n=131
Croatian: PREZISTA/ ritonavir 600/100 mg dva puta na dan n=131
English: Lopinavir/ritonavir 400/100 mg twice daily + OBR N=297
Croatian: Lopinavir/ritonavir 400/100 mg dva puta na dan + OOR n=297
English: Opaque, white, high density polyethylene (HDPE) plastic, 75 ml bottle containing 30 tablets, fitted with polypropylene (PP) child resistant closure.
Croatian: Neprozirna, bijela, plastična bočica od polietilena visoke gustoće (HDPE) od 75 ml, sadrži 30 tableta i zatvorena je sigurnosnim polipropilenskim (PP) zatvaračem za djecu.
English: Proportion (%) of patients with response (HIV-1 RNA < 50 copies/ml at week 24) to PREZISTA co-administered with ritonavir (600/100 mg twice daily) by baseline genotype a, and baseline darunavir FC and by use of enfuvirtide (ENF): As treated analysis of the POWER and DUET trials.
Croatian: Udio (%) bolesnika s odgovorom (HIV-1 RNK< 50 kopija/ml u 24. tjednu) na lijek PREZISTA primjenjenog istodobno s ritonavirom (600/100 mg dva puta na dan) po početnom genotipu a i početnoj
English: 675 mg PREZISTA/100 mg ritonavir once daily
Croatian: 675 mg PREZISTA/100 mg ritonavir jedanput na dan
English: Pharmacokinetic results of total darunavir after administration of darunavir/ritonavir at 600/100 mg twice daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy and postpartum Pharmacokinetics of total darunavir (mean ± SD)
Croatian: Farmakokinetički rezultati ukupnog darunavira nakon primjene darunavira/ritonavira 600/100 mg dva puta na dan, kao dijela antiretrovirusnog režima liječenja tijekom drugog trimestra trudnoće, trećeg trimestra trudnoće i postpartalnog razdoblja Farmakokinetika ukupnog darunavira (srednja vrijednost ± SD)
English: One dose is between 15 and 30 kilograms 375 milligram PREZISTA + 50 milligram ritonavir twice a day between 30 and 40 kilograms 450 milligram PREZISTA + 60 milligram ritonavir twice a day more than 40 kilograms*
Croatian: 375 miligrama lijeka PREZISTA + 50 miligrama ritonavira, dva puta na dan između 30 i 40 kilograma
English: PREZISTA 75 mg film-coated tablets EU/1/06/380/005
Croatian: PREZISTA 75 mg filmom obložene tablete EU/1/06/380/005
English: PREZISTA 150 mg film-coated tablets
Croatian: PREZISTA 150 mg filmom obložene tablete
English: Darunavir/ritonavir (600/100 mg twice daily or 800/100 mg once daily) in combination with a background regimen was evaluated in a clinical trial of 36 pregnant women (18 in each arm) during the second and third trimesters, and postpartum.
Croatian: U kliničkom ispitivanju s 36 trudnice (po 18 u svakoj skupini), procijenjena je terapija darunavir/ritonavir (600/100 mg dva puta na dan ili 800/100 mg jedanput dnevno) u kombinaciji s osnovnim režimom liječenja tijekom drugog i trećeg trimestra, te postpartalno.
English: For clinical trial results in ART-naïve adult patients, refer to the Summary of Product Characteristics for PREZISTA 400 mg and 800 mg tablets or 100 mg/ml oral suspension.
Croatian: Za rezultate kliničkog ispitivanja u odraslih bolesnika koji nisu prethodno liječeni ART-om, vidjeti Sažetak opisa svojstava lijeka za PREZISTA 400 mg i 800 mg tablete ili oralnu suspenziju od 100 mg/ml.
English: PREZISTA co-administered with low dose ritonavir can be used with these NRTIs without dose adjustment.
Croatian: PREZISTA istodobno primijenjena s niskom dozom ritonavira može se primjeniti s ovim NRTI lijekovima bez prilagodbe doze.
English: Co-administration of PREZISTA with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Croatian: Istodobna primjena PREZISTE s ovim antikoagulansima može povećati koncentracije antikoagulansa, što može povećati rizik od krvarenja. (CYP3A i/ili P-gp inhibicija)
English: Each ml of suspension contains 100 mg darunavir (as ethanolate).
Croatian: Jedan ml suspenzije sadrži 100 mg darunavira (u obliku darunaviretanolata).
English: PREZISTA co-administered with cobicistat lowers the creatinine clearance.
Croatian: PREZISTA istodobno primijenjena s kobicistatom snižava klirens kreatinina.
English: Dose adjustment for buprenorphine may not be necessary when co-administered with PREZISTA/ritonavir but a careful clinical monitoring for signs of opiate toxicity is recommended.
Croatian: PREZISTA/ritonavir, ali se preporučuje pažljivo kliničko praćenje znakova opijatne toksičnosti.
English: Each tablet contains 75 milligram of darunavir (as ethanolate).
Croatian: Jedna tableta sadrži 75 miligrama darunavira (u obliku darunaviretanolata).
English: PREZISTA cannot work properly without cobicistat or ritonavir.
Croatian: PREZISTA ne može pravilno djelovati bez kobicistata ili ritonavira.
English: Pharmacokinetic results of total darunavir after administration of darunavir/cobicistat 800/150 mg once daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy, and postpartum Pharmacokinetics of total darunavir (mean ± SD)
Croatian: Farmakinetički rezultati ukupnog darunavira nakon primjene darunavira/kobicistata 800/150 mg jedanput na dan kao dijela antiretrovirusnog režima, tijekom drugog tromjesečja trudnoće, trećeg tromjesečja trudnoće i u postpartalnom razdoblju Farmakinetika ukupnog darunavira (srednja vrijednost ± SD)
English: It is not recommended to co-administer PREZISTA with low dose ritonavir and boceprevir.
Croatian: Ne preporučuje se istodobna primjena lijeka PREZISTA s niskom dozom ritonavira i boceprevira.
English: 375 mg PREZISTA/50 mg ritonavir twice daily
Croatian: 375 mg PREZISTA/50 mg ritonavir, dva puta na dan
English: Concomitant use of everolimus and PREZISTA co-administered with low dose ritonavir is not recommended.
Croatian: Istodobna primjena everolimusa i PREZISTE istodobno primijenjene s niskom dozom ritonavira se ne preporučuje.
English: HIV-1 RNA < 50 copies/ml median CD4+ cell count change from baseline (x 10
Croatian: HIV-1 RNK < 50 kopija/ml medijan promjene broja CD4+ stanica od početne vrijednosti (x 10
English: Therapy with PREZISTA/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with PREZISTA/cobicistat should be switched to an alternative regimen (see sections 4.2 and 4.4).
Croatian: Liječenje lijekom PREZISTA/kobicistat se ne smije započinjati tijekom trudnoće, a žene koje zatrudne tijekom liječenja lijekom PREZISTA/kobicistat trebaju prijeći na zamjenski režim (vidjeti dijelove 4.2 i 4.4).
English: 800 mg PREZISTA/100 mg ritonavir once daily
Croatian: 800 mg PREZISTA/100 mg ritonavir jedanput na dan
English: Each film-coated tablet contains 75 mg darunavir (as ethanolate).
Croatian: Jedna filmom obložena tableta sadrži 75 mg darunavira (u obliku darunaviretanolata).
English: - Rifabutin (against bacterial infections) - Sildenafil, vardenafil, tadalafil (for erectile dysfunction or high blood pressure in the pulmonary circulation) - Amitriptyline, desipramine, imipramine, nortriptyline, paroxetine, sertraline, trazodone (to treat depression and anxiety) - Maraviroc (to treat HIV infection) - Methadone (to treat opiate dependance) - Carbamazepine, clonazepam (to prevent seizures or to treat certain types of nerve pain) - Colchicine (to treat gout or familial Mediterranean fever) - Bosentan (to treat high blood pressure in the pulmonary circulation) - Buspirone, clorazepate, diazepam, estazolam, flurazepam, midazolam when used as injection,
Croatian: Vorikonazol se smije uzimati samo nakon medicinske procjene. - rifabutin (protiv bakterijskih infekcija) - sildenafil, vardenafil, tadalafil (za erektilnu disfunkciju ili povišeni krvni tlak u plućnom krvotoku) - amitriptilin, desipramin, imipramin, nortriptilin, paroksetin, sertralin, trazodon (za liječenje depresije i tjeskobe) - maravirok (za liječenje HIV infekcije) - metadon (za liječenje ovisnosti o opijatima) - karbamazepin, klonazepam (za sprečavanje epileptičkih napadaja ili za liječenje određenih vrsta neurološke boli) - kolhicin (za liječenje gihta ili obiteljska mediteranska vrućica) - bosentan (za liječenje povišenog krvnog tlaka u plućnom krvotoku) - buspiron, klorazepat, diazepam, estazolam, flurazepam, midazolam kada se koristi u obliku injekcije, zolpidem (sedativi) - perfenazin, risperidon, tioridazin ( za liječenje psihijatrijskih stanja).
English: PREZISTA 800 mg film-coated tablets
Croatian: PREZISTA 800 mg filmom obložene tablete
English: The use of carbamazepine with PREZISTA co-administered with cobicistat is contraindicated (see section 4.3).
Croatian: Primjena karbamazepina s lijekom PREZISTA istodobno primijenjenog s kobicistatom je kontraindicirana (vidjeti dio 4.3).
English: The child must eat a meal or a snack within 30 minutes prior to taking PREZISTA and ritonavir.
Croatian: Unutar 30 minuta prije uzimanja lijeka PREZISTA i ritonavira dijete mora pojesti obrok ili užinu.
English: What PREZISTA looks like and contents of the pack Film-coated, orange, oval shaped tablet, mentioning TMC on one side, 600MG on the other side.
Croatian: Narančasta, duguljasta, filmom obložena tableta s oznakom TMC s jedne strane, a 600MG s druge strane.
English: Hence, concomitant use of boosted PREZISTA and the combination product lopinavir/ritonavir is contraindicated (see section 4.3).
Croatian: Odavde proizlazi da je istodobna primjena pojačane PREZISTE i kombiniranog lijeka lopinavir/ritonavir kontraindicirana (vidjeti dio 4.3).
English: - Buprenorphine/naloxone (medicines to treat opioid dependence) - Salmeterol (medicine to treat asthma) - Artemether/lumefantrine (a combination medicine to treat malaria) - Dasatinib, everolimus, irinotecan, nilotinib, vinblastine, vincristine (to treat cancer) - Sildenafil, tadalafil, vardenafil (for erectile dysfunction or to treat a heart and lung disorder called pulmonary arterial hypertension) - Glecaprevir/pibrentasvir, simeprevir (to treat hepatitis C infection) - Fentanyl, oxycodone, tramadol (to treat pain) - Fesoterodine, solifenacin (to treat urologic disorders).
Croatian: Ako se ne mogu primijeniti alternativni lijekovi, ovi lijekovi se smiju primjenjivati samo nakon medicinske procjene te uz pomni liječnički nadzor zbog nuspojava kortikosteroida. - buprenorfin/nalokson (lijekovi za liječenje ovisnosti o opioidima) - salmeterol (lijek za liječenje astme) - artemeter/lumefantrin (kombinirani lijek za liječenje malarije) - dasatinib, everolimus,irinotekan, nilotinib, vinblastin, vinkristin (za liječenje raka) - sildenafil, tadalafil, vardenafil (za liječenje erektilne disfunkcije ili srčanog i plućnog poremećaja koji se naziva plućna arterijska hipertenzija) - glekaprevir/pibrentasvir, simeprevir (za liječenje infekcije hepatitisom C) - fentanil, oksikodon, tramadol (za liječenje boli) - fesoterodin, solifenacin (liječenje poremećaja mokraćnog sustava).
English: - In the morning, take two 300 milligram PREZISTA tablets together with 100 milligram ritonavir.
Croatian: - Ujutro uzmite dvije tablete lijeka PREZISTA od 300 miligrama zajedno sa 100 miligrama ritonavira.
English: PREZISTA co-administered with low dose ritonavir can be expected to increase the plasma concentrations of calcium channel blockers.
Croatian: Za lijek PREZISTA istodobno primijenjen s niskom dozom ritonavira može se očekivati da povisi koncentracije blokatora kalcijevih kanala u plazmi. (inhibicija CYP3A i/ili CYP2D6)
English: The pharmacokinetics of darunavir in combination with ritonavir taken once daily in 12 ART-naïve paediatric patients, aged 12 to < 18 years and weighing at least 40 kg, showed that PREZISTA/ritonavir 800/100 mg once daily results in darunavir exposure that was comparable to that achieved in adults receiving PREZISTA/ritonavir 800/100 mg once daily.
Croatian: Farmakokinetika darunavira u kombinaciji s ritonavirom uzetih jedanput na dan, kod 12 pedijatrijskih bolesnika koji nisu prethodno liječeni, u dobi od 12 do < 18 godina s težinom najmanje 40 kg, pokazala je da PREZISTA/ritonavir 800/100 mg jedanput na dan rezultira izloženošću darunaviru koja je usporediva s onom kod odraslih koji primaju lijek PREZISTA/ritonavir od 800/100 mg jedanput na dan.
English: Pharmacokinetic results of total darunavir after administration of darunavir/ritonavir at 800/100 mg once daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy and postpartum Pharmacokinetics of total darunavir (mean ± SD)
Croatian: Farmakokinetički rezultati ukupnog darunavira nakon primjene darunavira/ritonavira 800/100 mg jedanput dnevno kao dijela antiretrovirusnog režima liječenja tijekom drugog trimestra trudnoće, trećeg trimestra trudnoće i postpartalnog razdoblja Farmakokinetika ukupnog darunavira (srednja vrijednost ± SD)
English: - In the evening, take two 300 milligram PREZISTA tablets together with 100 milligram ritonavir.
Croatian: - Navečer uzmite dvije tablete lijeka PREZISTA od 300 miligrama zajedno sa 100 miligrama ritonavira.
English: Hence, concomitant use of PREZISTA co-administered with low dose ritonavir and the combination product lopinavir/ritonavir is contraindicated (see section 4.3).
Croatian: Odavde proizlazi da je istodobna primjena lijeka PREZISTA s niskom dozom ritonavira i kombiniranog lijeka s lopinavira/ritonavira kontraindicirana (vidjeti dio 4.3).
English: Therefore, therapy with PREZISTA/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with PREZISTA/cobicistat should be switched to an alternative regimen (see sections 4.4 and 4.6).
Croatian: Stoga se liječenje lijekom PREZISTA/kobicistat ne smije započinjati tijekom trudnoće, a žene koje zatrudne tijekom liječenja lijekom PREZISTA/kobicistat trebaju prijeći na zamjenski režim (vidjeti dijelove 4.4 i 4.6).
English: These active substances include e.g.: - alfuzosin - amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine - astemizole, terfenadine - colchicine when used in patients with renal and/or hepatic impairment (see section 4.5)
Croatian: Ti djelatne tvari, primjerice uključuju: - alfuzozin - amiodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin - astemizol, terfenadin - kolhicin kada se primjenjuje kod bolesnika s oštećenjem bubrega i/ili jetre (vidjeti dio 4.5) - ergot derivate (npr. dihidroergotamin, ergometrin, ergotamin, metilergonovin) - elbasvir/grazoprevir
English: Co-administration of boosted PREZISTA with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Croatian: Istodobna primjena pojačane PREZISTE s ovim antikoagulansima može povećati koncentracije antikoagulansa, što može povećati rizik od krvarenja. (CYP3A i/ili P-gp inhibicija)
English: PREZISTA co-administered with low dose ritonavir and atazanavir can be used without dose adjustments.
Croatian: PREZISTA istodobno primijenjena s niskom dozom ritonavira i atazanavirom može se primjeniti bez prilagodbe doze.
English: 600 mg PREZISTA/100 mg ritonavir once daily
Croatian: 600 mg PREZISTA/100 mg ritonavir jedanput na dan
English: PREZISTA/ritonavir 800/100 mg once daily in ART-experienced patients should not be used in patients with one or more darunavir resistance associated mutations (DRV-RAMs) or HIV-1 RNA ≥ 100,000 copies/ml or CD4+ cell count < 100 cells x 10
Croatian: Među bolesnicima prethodno liječenim ART-om, PREZISTA/ritonavir od 800/100 mg jedanput na dan ne smije se primjenjivati u bolesnika s jednom ili više mutacija povezanih s rezistencijom na darunavir (DRV-RAM) ili s HIV-1 RNK ≥ 100 000 kopija/ml ili brojem CD4+ stanica < 100 stanica x 10
English: Outcomes at week 48
Croatian: Ishodi u 48.tjednu