FrancophonIA/ELRC3.0 huggingface dataset:
English: Depending upon your dose, you may have extra needles and swabs left in the pack.
Danish: Afhængigt af Deres dosis kan De have ekstra kanyler og renseservietter i pakningen.
English: if you have thyroid disease that is not well controlled.
Danish: hvis De har thyreoideasygdom, der ikke er velkontrolleret.
English: If you are prescribed Viraferon in combination with ribavirin, ribavirin can be very damaging to an unborn baby, thus both female and male patients must take special precautions in their sexual activity if there is any chance for pregnancy to occur: - if you are a girl or a woman of childbearing age, you must have a negative pregnancy test before treatment, each month during treatment, and for the 4 months after treatment is stopped.
Danish: Hvis De har fået foreskrevet Viraferon i kombination med ribavirin, kan ribavirin være yderst skadelig for et ufødt barn, og både kvindelige og mandlige patienter skal derfor tage særlige forholdsregler i deres seksuelle aktivitet, hvis der er nogen mulighed for at en graviditet kan opstå: - hvis De er en pige eller kvinde i den fødedygtige alder, skal De have en negativ graviditetstest før behandling, hver måned under behandling, og i 4 måneder efter behandlingen er stoppet.
English: The increased response rate to the combination of Viraferon + ribavirin, compared with Viraferon alone, is maintained across all subgroups.
Danish: Den øgede responsrate ved kombinationen af Viraferon + ribavirin, sammenlignet med Viraferon alene, er opretholdt på tværs af alle undergrupper.
English: Any unused product must be discarded after withdrawal of the dose.
Danish: Ikke anvendt lægemiddel skal kasseres efter udtrækning af dosis.
English: Current treatment guidelines should be consulted as to whether a liver biopsy is needed prior to commencing treatment.
Danish: Gældende behandlingsvejledninger bør overvejes med hensyn til, om en leverbiopsi er nødvendig før behandling initieres.
English: During treatment for hepatitis B or C the recommended testing schedule is at weeks 1, 2, 4, 8, 12, 16, and every other month, thereafter, throughout treatment.
Danish: Under behandling af hepatitis B eller C, anbefales det at udføre disse kontroller ved uge 1, 2, 4, 8, 12 og 16 samt hver anden måned derefter under hele behandlingen.
English: Hypertriglyceridemia and aggravation of hypertriglyceridemia, sometimes severe, have been observed.
Danish: Der er set hypertriglyceridæmi og forværring af hypertriglyceridæmi, undertiden alvorlig.
English: Genotype 1 ≤ 2 million copies/ml Genotype 1 > 2 million copies/ml
Danish: Genotype 1 ≤ 2 millioner kopier/ml Genotype 1 > 2 millioner kopier/ml
English: Tmax (hr) Cmax (ng/ml) AUC* Apparent clearance l/hr/kg
Danish: Tmax (timer) Cmax (ng/ml) AUC* Tilsyneladende clearance l/time/kg
English: After each use, the injection needle must be discarded safely and the pen must be returned immediately to the refrigerator.
Danish: Efter hver anvendelse skal kanylen kasseres forsvarligt, og pennen skal straks lægges tilbage i køleskabet.
English: Viraferon 3 MIU/m
Danish: Viraferon 3 MIE/m
English: Although not all of these side effects may occur, they may need medical attention if they do.
Danish: Selv om ikke alle disse bivirkninger forekommer, kan de, hvis de forekommer, kræve medicinsk overvågning.
English: The elimination half-lives of interferon injections were approximately two to three hours, and six to seven hours, respectively.
Danish: Eliminationshalveringstiden af interferon-injektioner var henholdsvis cirka to til tre timer og seks til syv timer.
English: Interferon neutralising factors are antibodies which neutralise the antiviral activity of interferon.
Danish: Interferonneutraliserende faktorer er antistoffer, som neutraliserer den antivirale virkning af interferon.
English: There are no adequate data from the use of interferon alfa-2b in pregnant women.
Danish: Der foreligger ikke tilstrækkelige data om brugen af interferon alfa-2b hos gravide kvinder.
English: What Viraferon is and what it is used for 2.
Danish: Viraferons virkning og hvad De skal bruge det til 2.
English: Viraferon will add to the effects of substances that slow down your nervous system, possibly causing drowsiness.
Danish: Viraferon vil forøge virkningerne af stoffer, der hæmmer Deres nervesystem, muligvis ved at forårsage døsighed.
English: Vial alone is also available.
Danish: Hætteglas alene er også til rådighed.
English: Serum levels were below the detection limit 16 and 24 hours, respectively, post-injection.
Danish: Serumniveauerne var under detektionsgrænsen efter henholdsvis 16 og 24 timer efter injektionen.
English: Be sure to tell your doctor if you are taking the Chinese herbal medication Shosaikoto.
Danish: Det er vigtigt at fortælle Deres læge, hvis De anvender den kinesiske urtemedicin shosaikoto.
English: If you have set a wrong dose, simply turn the cap back (anti-clockwise) as far as you can until the push button is fully home and start again.
Danish: Hvis De har indstillet dosis forkert, drej blot penhætten tilbage (mod uret) så langt som De kan, indtil trykknappen er helt tilbage og start forfra igen.
English: They are produced and secreted by cells in response to viral infections or various synthetic and biological inducers.
Danish: De produceres og udskilles af celler som respons på virale infektioner eller forskellige syntetiske og biologiske substanser.
English: These undesirable effects have also been reported with Viraferon alone.
Danish: Disse bivirkninger er også rapporteret med Viraferon alene.
English: Defined as HCV-RNA below limit of detection using a research based RT-PCR assay at end of treatment and during follow-up period
Danish: Defineret som HCV RNA under detektionsgrænsen ved brug af en forskningsbaseret RT-PCR analyse ved afslutningen af behandlingen og under opfølgningsperioden
English: Subcutaneous use:
Danish: Subkutan anvendelse:
English: Daily dosing of cynomolgus monkeys with 20 x 10
Danish: Daglige doser til cynomolgus aber med 20 x 10
English: Pull the needle straight out of the skin.
Danish: Træk kanylen lige ud af huden.
English: Agitate gently to facilitate complete dissolution of the powder.
Danish: Ryst forsigtigt for at fremskynde den fuldstændige opløsning af pulveret.
English: if you have psoriasis, it may get worse during treatment with Viraferon.
Danish: hvis De har psoriasis, kan den forværres under behandling med Viraferon.
English: If you have the impression that the effect of Viraferon is too strong or too weak, talk to your doctor or pharmacist.
Danish: Hvis De mener, at virkningerne af Viraferon er for kraftige eller for svage, bør De tale med Deres læge eller apotek herom.
English: Patients should brush their teeth thoroughly twice daily and have regular dental examinations.
Danish: Patienter bør børste deres tænder omhyggeligt to gange daglig og have regelmæssige tandeftersyn.
English: If you are injecting Viraferon yourself, please be sure that the dose that has been prescribed for you is clearly provided with the package of medicine you receive.
Danish: Hvis De selv injicerer Viraferon, så vær sikker på, at den dosis, der er blevet foreskrevet til Dem, gives tydeligt med den lægemiddelpakning, De modtager.
English: Ribavirin therapy is contraindicated in women who are pregnant.
Danish: Ribavirin behandling er kontraindiceret hos kvinder, der er gravide.
English: The results of several studies suggest that, once bound to the cell membrane, interferon initiates a complex sequence of intracellular events that include the induction of certain enzymes.
Danish: Resultaterne af adskillige undersøgelser antyder, at når interferon er bundet til cellemembranen starter en kompleks sekvens af intracellulære reaktioner, som omfatter induktion af visse enzymer.
English: Extreme care must be taken to avoid pregnancy in female patients or in partners of male patients taking Viraferon in combination with ribavirin.
Danish: Den yderste forsigtighed skal udvises for at undgå graviditet hos kvindelige patienter eller hos partnere af mandlige patienter, der får Viraferon i kombination med ribavirin.
English: if you have poor kidney or liver function.
Danish: hvis De har dårlig nyre- eller leverfunktion.
English: The clinical incidence of neutralising factors developing in cancer patients treated systemically is 2.9 % and in chronic hepatitis patients is 6.2 %.
Danish: Den kliniske hyppighed af neutraliserende faktorer, som udvikledes hos cancerpatienter, der blev behandlet systemisk, var 2,9 % og hos patienter med kronisk hepatitis 6,2 %.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Danish: Inden for hver enkelt frekvensgruppe er bivirkningerne opstillet efter faldende alvorlighed.
English: d: ribavirin dosing was 800 mg for patients < 60 kg, 1,000 mg for patients 60-75 kg, and 1,200 mg for patients > 75 kg.
Danish: d: ribavirin dosering var 800 mg for patienter < 60 kg, 1.000 mg for patienter 60-75 kg og 1.200 mg for patienter > 75 kg.
English: In clinical trials of 118 children or adolescents 3 to 16 years of age, 6 % discontinued therapy due to adverse events.
Danish: I kliniske undersøgelser med 118 børn og unge i alderen 3 til 16 år afbrød 6 % behandling på grund af bivirkninger.
English: if you have a history of autoimmune disease, or have had an organ transplant and are taking medicine that suppresses your immune system (your immune system helps protect you from infection).
Danish: hvis De tidligere har haft autoimmun sygdom, eller har fået en organtransplantation og anvender medicin, der undertrykker Deres immunsystem (Deres immunsystem hjælper med at beskytte Dem mod infektioner).
English: Instruct the patient that any extra needles and swabs that remain after the final dose has been taken from the pen, must be discarded appropriately and safely.
Danish: Patienten bør instrueres i, at eventuelle ekstra kanyler og renseservietter, der er tilbage efter sidste dosis er udtaget af pennen, skal smides ud på en passende og sikker måde.
English: Interferons may cause unusual tiredness; if you are injecting this medicine yourself, or giving it to a child, use it at bedtime.
Danish: Interferoner kan forårsage usædvanlig træthed; hvis De selv injicerer denne medicin, eller giver den til et barn, bør de gøre det før sengetid.
English: All patients were followed for an additional 6 months after the end of treatment for the determination of sustained virologic response.
Danish: Alle patienter blev fulgt i yderligere 6 måneder efter afsluttet behandling for bestemmelse af vedvarende virologisk respons.
English: The interferons are a family of small protein molecules with molecular weights of approximately 15,000 to 21,000 daltons.
Danish: Interferoner er en familie af små proteinmolekyler med molekylevægte på cirka 15.000-21.000 daltons.
English: §, influenza-like symptoms
Danish: §, influenzalignende symptomer
English: The adverse reactions listed in Table 1 are based on experience from clinical trials and post-marketing.
Danish: De bivirkninger, der er listet i Tabel 1, er baseret på erfaringer fra kliniske undersøgelser og post-marketing.
English: Growth rate decrease (height and/or weight decrease for age)
Danish: Fald i væksthastighed (højde og/eller vægtfald i forhold til alder)
English: When medicines are made from human blood or plasma, certain measures are put in place to prevent infections being passed on to patients.
Danish: Når lægemidler fremstilles af humant blod eller plasma, fastlægges visse metoder for at forebygge, at infektioner overføres til patienter.
English: If not used immediately, it must be stored at 2°C - 8°C in the refrigerator and used within 24 hours.
Danish: Hvis den ikke anvendes straks, skal den opbevares ved 2°C - 8°C i køleskabet og bruges inden 24 timer.
English: *AUC12 (ng.hr/ml) for ribavirin; AUC0-24 (IU.hr/ml) for Viraferon
Danish: *AUC12 (ng.time/ml) for ribavirin; AUC0-24 (IE.time/ml) for Viraferon
English: Mononeuropathies, coma
Danish: Mononeuropatier, koma
English: Hypotension may occur during Viraferon therapy or up to two days post-therapy and may require supportive treatment.
Danish: Hypotension kan opstå under eller op til to dage efter Viraferon-behandling og kan kræve understøttende behandling.
English: Viraferon in combination with ribavirin:
Danish: Viraferon i kombination med ribavirin:
English: Do not use Viraferon if you notice changes in the appearance of Viraferon.
Danish: Brug ikke Viraferon, hvis De bemærker ændringer i udseendet af Viraferon.
English: If there is bleeding, cover with an adhesive bandage.
Danish: Hvis der er blødning, så dæk med et plaster.
English: If this is a multidose vial, you will only have to remove the cap when preparing the first dose.
Danish: Hvis dette er et flerdosis hætteglas, skal De kun fjerne låget ved forberedelse af den første dosis.
English: Children and adolescents should be monitored every 3 months for evidence of thyroid dysfunction (e.g. TSH).
Danish: Børn og unge patienter bør monitoreres hver 3. måned for tegn på thyreoideadysfunktion (f.eks. TSH).
English: This action inhibits viral replication or if replication occurs, the progeny virions are unable to leave the cell.
Danish: Denne virkning hæmmer virusreplikation, eller hvis replikation er i gang, er de dannede virioner ude af stand til at forlade cellen.
English: This also applies to unknown or emerging viruses and other pathogens.
Danish: Dette gælder også for ukendte eller nye opstående vira og andre patogener.
English: The best way to use Viraferon in this indication is in combination with ribavirin.
Danish: Den bedste måde at anvende Viraferon ved denne indikation er i kombination med ribavirin.
English: Your doctor has determined the exact dosage for administration of Viraferon according to your individual needs.
Danish: Deres læge har bestemt den nøjagtige dosering for indgift af Viraferon efter Deres individuelle behov.
English: SP (Brinny) Company Innishannon - County Cork Ireland
Danish: Innishannon, County Cork Irland
English: Patients predisposed to the development of autoimmune disorders may be at increased risk.
Danish: Patienter, der er prædisponerede for udviklingen af autoimmune lidelser, kan have øget risiko.
English: Adult patients:
Danish: Voksne patienter:
English: In addition some patients may experience vomiting.
Danish: Nogle patienter kan desuden opleve opkastning.
English: For all patients, if no improvement on serum HBV-DNA is observed after 3 to 4 months of treatment (at the maximum tolerated dose), discontinue Viraferon therapy.
Danish: For alle patienter gælder, at hvis der ikke ses nogen forbedring i serum HBV-DNA efter 3 til 4 måneders behandling (ved den højeste tolererede dosis), skal Viraferon behandlingen afbrydes.
English: Women of childbearing potential have to use effective contraception during treatment.
Danish: Kvinder i den fødedygtige alder skal anvende effektiv antikonception under behandlingen.
English: A general reversal of these trends was noted during the 6 months follow-up post treatment.
Danish: En generel reversering af disse tendenser sås under 6 måneders opfølgning efter behandling.
English: In addition, injection site disorders, fever, anorexia, vomiting, and emotional lability occurred more frequently in children and adolescents compared to adult patients.
Danish: Derudover forekom lidelser på injektionsstedet, feber, anoreksi, opkastning og emotionel labilitet hyppigere hos børn og unge sammenlignet med voksne patienter.
English: Dyspnoea*, coughing*
Danish: Dyspnø*, hoste*
English: All patients in the chronic hepatitis C studies had a liver biopsy before inclusion, but in certain cases (i.e. patients with genotype 2 and 3), treatment may be possible without histological confirmation.
Danish: Alle patienter i de kliniske undersøgelser af kronisk hepatitis C fik foretaget leverbiopsi før inklusion, men i visse tilfælde (for eksempel patienter med genotype 2 og 3), kan behandling være mulig uden histologisk verifikation.
English: Children and adolescents - Chronic Hepatitis C
Danish: Børn og unge - kronisk hepatitis C
English: Appropriate vaccination (hepatitis A and B) should be considered for patients in regular/repeated receipt of human plasma-derived albumin.
Danish: Passende vaccination (hepatitis A og B) bør overvejes hos patienter, der regelmæssigt/gentagne gange får humant albumin udvundet fra plasma.
English: Therefore, the risk/benefit of the combined use of interferon alfa-2b and ribavirin should be assessed in young children prior to the initiation of therapy.
Danish: Risk/benefit af den kombinerede anvendelse af interferon alfa-2b og ribavirin bør derfor vurderes hos små børn før initiering af behandling.
English: It is thought that this process, at least in part, is responsible for the various cellular responses to interferon, including inhibition of virus replication in virus-infected cells, suppression of cell proliferation and such immunomodulating activities as enhancement of the phagocytic activity of macrophages and augmentation of the specific cytotoxicity of lymphocytes for target cells.
Danish: Det formodes, at denne proces, i det mindste delvis, er ansvarlig for de forskellige cellulære reaktioner på interferon, inklusiv hæmning af virusreplikation i virusinficerede celler, suppression af celledeling og sådanne immunmodulerende aktiviteter som øgning af den fagocytære aktivitet af makrofager og øgning af den specifikke cytotoksicitet af lymfocytter på målcellerne.
English: Proper precautions should be taken during reconstitution to prevent microbial contamination (refer to package leaflet).
Danish: Der bør tages de rette forholdsregler under tilberedning for at forhindre mikrobiel forurening (se indlægssedlen).
English: Treatment should be blood cells < 1,500/mm
Danish: Behandlingen blodlegemer < 1.500/mm
English: B-2220 Heist-op-den-Berg Belgium
Danish: B-2220 Heist-op-den-Berg Belgien
English: Narcotics, hypnotics or sedatives must be administered with caution when used concomitantly with Viraferon.
Danish: Narkotika, hypnotika og sedativa skal indgives med forsigtighed samtidig med Viraferon.
English: Toxicity was demonstrated in monkeys given 100 x 106 IU/kg/day for 3 months.
Danish: Toksicitet blev påvist i aber, der fik 100 x 106 IE/kg/dag i 3 måneder.
English: Your doctor has prescribed Viraferon specifically for you and your current condition; do not share this medicine with anyone else.
Danish: SÅDAN SKAL DE BRUGE VIRAFERON Deres læge har ordineret Viraferon specielt til Dem og Deres nuværende tilstand; del ikke denne medicin med andre.
English: Moreover children treated with interferon alfa-2b experienced a reduced rate of growth and some cases of depression were observed.
Danish: Herudover fik børn behandlet med interferon alfa-2b en nedsat væksthastighed og nogle tilfælde af depression sås.
English: For the next step hold the pen in the middle of the barrel.
Danish: Under næste trin holdes pennen på midten af cylinderen.
English: Viraferon is available in three different pack sizes:
Danish: Viraferon er tilgængelig i tre forskellige pakningsstørrelser:
English: Patients are to be advised that they may develop fatigue, somnolence, or confusion during treatment with Viraferon, and therefore it is recommended that they avoid driving or operating machinery.
Danish: Patienter bør informeres om, at de kan udvikle træthed, døsighed eller konfusion under behandling med Viraferon, og derfor anbefales det, at de undgår at føre bil og betjene maskiner.
English: Due to reports of interferon alpha exacerbating pre-existing psoriatic disease and sarcoidosis, use of Viraferon in patients with psoriasis or sarcoidosis is recommended only if the potential benefit justifies the potential risk.
Danish: På grund af rapporter med interferon alfa og akut forværring af tidligere psoriasislidelse og sarcoidosis, anbefales brug af Viraferon hos patienter med psoriasis eller sarcoidosis kun, hvis den forventede gavnlige effekt opvejer den mulige risiko.
English: Therefore, check with your doctor or pharmacist about drinking alcoholic beverages, or taking sleeping pills, sedatives or strong pain medications.
Danish: Spørg derfor Deres læge eller apotek til råds om indtagelse af alkoholiske drikkevarer eller anvendelse af sovepiller, beroligende eller stærkt smertestillende medicin.
English: The pharmacokinetics of Viraferon and ribavirin (dose-normalized) are similar in adults and children or adolescents.
Danish: Farmakokinetikken for Viraferon og ribavirin (dosis-normaliseret) er ens hos voksne og børn eller unge.
English: You should brush your teeth thoroughly twice daily and have regular dental examinations.
Danish: De bør børste Deres tænder omhyggeligt to gange daglig og få foretaget regelmæssige tandeftersyn.
English: All Genotype 1,
Danish: Alle Genotype 1,
English: Decreased serum estradiol and progesterone concentrations have been reported in women treated with human leukocyte interferon.
Danish: Nedsatte serum østradiol og progesteron koncentrationer har været rapporteret hos kvinder behandlet med human leukocyt-interferon.
English: Break the top of the ampoule of solvent.
Danish: Bræk toppen af ampullen med solvens.
English: Regardless of genotype, patients who received Viraferon in combination with ribavirin and received ≥ 80 % of their treatment had a higher sustained response 6 months after 1 year of treatment than those who took < 80 % of their treatment (56 % vs. 32 % in trial C/I98-580).
Danish: Uafhængigt af genotype havde patienter, som fik Viraferon i kombination med ribavirin og fik ≥ 80 % af deres behandling, et højere vedvarende respons 6 måneder efter 1 års behandling end dem, der anvendte < 80 % af deres behandling (56 % mod 32 % i undersøgelse C/I98-580).
English: Tell your doctor if you are taking theophylline or aminophylline for asthma, and about all other medication you are taking, or have taken recently, even those not prescribed, as the dose of some medications may have to be adjusted while you are treated with Viraferon.
Danish: Fortæl deres læge, om De anvender theophyllin eller aminophyllin for asthma, og om al anden medicin, De anvender, eller for nylig har anvendt, også hvis der er tale om ikke-receptpligtige lægemidler, idet dosis af visse lægemidler eventuelt skal justeres, mens De behandles med Viraferon.
English: Push up the plunger slowly back to the correct dose.
Danish: Tryk stemplet langsomt op tilbage til den korrekte dosis.
English: if you have received an organ transplant, either kidney or liver, interferon treatment may increase the risk of rejection.
Danish: hvis De har fået foretaget en organtransplantation, enten nyre eller lever, kan interferon behandling øge risikoen for frastødning.
English: SP Europe 73, rue de Stalle B-1180 Bruxelles Belgium
Danish: SP Europe 73, rue de Stalle B-1180 Bruxelles Belgien
English: Important information about some of the ingredients of Viraferon Your doctor may recommend that you consider vaccination against hepatitis A and B if you regularly/repeatedly receive human plasma-derived albumin.
Danish: Vigtig information om nogle af de øvrige indholdsstoffer i Viraferon Deres læge vil måske anbefale, at De overvejer vaccination mod hepatitis A og B, hvis De regelmæssigt/gentagne gange får humant albumin udvundet fra plasma.
English: In combination therapy with ribavirin, take notice of the respective informing texts of ribavirin containing medicinal products.
Danish: I kombinationsbehandling med ribavirin, bemærk da de respektive informerende tekster vedrørende lægemidler indeholdende ribavirin.
English: Your doctor may prescribe a different dose of Viraferon alone or in combination with other medicines (e.g. ribavirin).
Danish: Deres læge kan ordinere en anden dosis af Viraferon alene eller i kombination med andre lægemidler (såsom ribavirin).
English: Very rarely, seizures have occurred with high doses of Viraferon.
Danish: Meget sjældent er der set kramper ved høje doser af Viraferon.
English: Efficacy was defined as sustained virologic response, 6 months after the end of treatment.
Danish: Effekt blev defineret som vedvarende virologisk respons 6 måneder efter afsluttet behandling.