FrancophonIA/ELRC3.0 huggingface dataset:
English: Recommended Dose* for ISENTRESS Chewable Tablets for Paediatric Patients Weighing at Least 25 kg
Croatian: * ISENTRESS tableta za žvakanje za pedijatrijske bolesnike tjelesne težine najmanje 25 kg
English: Thus, the data indicate that the major mechanism of clearance of raltegravir in humans is UGT1A1-mediated glucuronidation.
Croatian: Ovi podaci ukazuju na to da je glavni mehanizam klirensa raltegravira u ljudi glukuronidacija posredovana enzimom UGT1A1.
English: Dizziness has been reported in some patients during treatment with regimens containing raltegravir.
Croatian: U nekih bolesnika koji su kao dio režima liječenja primali raltegravir prijavljena je omaglica.
English: Raltegravir 400 mg twice daily (N = 266)
Croatian: Raltegravir 400 mg dvaput na dan (N = 266)
English: 1 sachet of Isentress granules
Croatian: 1 vrećica Isentress granula
English: • bloating; abdominal pain; diarrhoea; excessive gas in the stomach or bowel; feeling sick;
Croatian: • nadutost; bol u trbuhu; proljev; previše plinova u želucu ili crijevima; mučnina; povraćanje;
English: Push the plunger into the barrel of the syringe as far as it goes.
Croatian: Gurnite klip u tijelo štrcaljke sve do kraja.
English: Weight based dosing, see dosing table for granules for oral suspension 19 *Number of patients with intensive pharmacokinetic (PK) results at the final recommended dose.
Croatian: od 3 do manje od 20 kg oralna suspenzija doziranje na temelju tjelesne težine, vidjeti tablice za doziranje granula za oralnu suspenziju *Broj bolesnika s intenzivnim farmakokinetičkim (PK) rezultatima pri konačnoj preporučenoj dozi.
English: Therefore, ISENTRESS should be used with caution in patients with severe hepatic impairment (see sections 4.4 and 5.2).
Croatian: Stoga ISENTRESS treba primjenjivati uz oprez u bolesnika s teškim oštećenjem funkcije jetre (vidjeti dijelove 4.4 i 5.2).
English: The other ingredients are: microcrystalline cellulose, hypromellose 2910, croscarmellose sodium and magnesium stearate.
Croatian: Drugi sastojci su: mikrokristalična celuloza, hipromeloza 2910, umrežena karmelozanatrij i magnezijev stearat.
English: • visual disturbance
Croatian: • smetnje vida
English: The impact of medicinal products that are strong inducers of UGT1A1 such as rifampicin on raltegravir 1,200 mg once daily is unknown, but co-administration is likely to decrease raltegravir trough levels based on the reduction in trough concentrations observed with raltegravir 400 mg twice daily; therefore, co-administration with raltegravir 1,200 mg once daily is not recommended.
Croatian: Induktori enzima koji sudjeluju u metabolizmu lijekova Utjecaj lijekova koji su snažni induktori UGT1A1, kao što je rifampicin, na raltegravir u dozi od 1200 mg jedanput na dan nije poznat, no njihova istodobna primjena vjerojatno će sniziti najniže koncentracije raltegravira, s obzirom na to da je kod istodobne primjene s raltegravirom od 400 mg dvaput na dan zapaženo sniženje najnižih koncentracija raltegravira.
English: The 100 mg chewable tablet can be divided into equal 50 mg doses.
Croatian: Tableta za žvakanje od 100 mg može se podijeliti na jednake doze od 50 mg.
English: Tell your doctor, pharmacist or nurse if you have had problems with your liver before, including hepatitis B or C. Your doctor may evaluate how severe your liver disease is before deciding if you can take this medicine.
Croatian: Obavijestite liječnika, ljekarnika ili medicinsku sestru ako ste ranije već imali tegoba s jetrom, uključujući hepatitis B ili C.
English: Film-coating - Lactose monohydrate - Hypromellose 2910 - Titanium dioxide - Triacetin - Iron oxide yellow - Black iron oxide
Croatian: Film ovojnica - laktoza hidrat - hipromeloza 2910 - titanijev dioksid - triacetin - željezov oksid, žuti - željezov oksid, crni
English: Raltegravir 1,200 mg is not recommended during pregnancy.
Croatian: Ne preporučuje se primjena raltegravira u dozi od 1200 mg u trudnoći.
English: Geometric mean (%CV C12hr (nM)
Croatian: Geometrijska srednja vrijednost (%CV C12h (nM)
English: • chest discomfort; chills; swelling of face; feeling jittery; generally feeling unwell; neck mass; swelling of hands, ankles or feet; pain
Croatian: • osjećaj nelagode u prsima; zimica; oticanje lica; osjećaj nervoze; opće loše osjećanje; stvaranje nakupine tkiva na vratu; oticanje šaka, gležnjeva ili stopala; bol
English: The 400 mg tablet should not be used to administer 1,200 mg once daily regimen (please refer to the 400 mg Summary of Product Characteristics).
Croatian: Tablete od 400 mg ne smiju se koristiti u režimu liječenja dozom od 1200 mg jedanput na dan (vidjeti sažetak opisa svojstava lijeka za tabletu od 400 mg).
English: 1.5 x 100 mg twice daily *The weight-based dosing recommendation for the chewable tablet, and oral suspension in 10mL of water is based on approximately 6 mg/kg/dose twice daily (see section 5.2).
Croatian: 1,5 x 100 mg dvaput na dan Preporuke za doziranje tableta za žvakanje i oralne suspenzije u 10 ml vode prema tjelesnoj težini temelje se na približnoj dozi od 6 mg/kg dvaput na dan (vidjeti dio 5.2).
English: UGT1A1 Polymorphism
Croatian: Polimorfizam UGT1A1
English: Table 9: Raltegravir Pharmacokinetic Parameters IMPAACT P1110 Following Age and Weight Based Dosing of the Granules for Suspension
Croatian: Farmakokinetički parametri raltegravira u ispitivanju IMPAACT P1110 nakon primjene granula za suspenziju u dozi određenoj prema dobi i tjelesnoj težini
English: Based on in vitro and in vivo studies, raltegravir is eliminated mainly by metabolism via a UGT1A1-mediated glucuronidation pathway.
Croatian: Ispitivanja in vitro i in vivo pokazuju da se raltegravir eliminira uglavnom metaboliziranjem putem glukuronidacije posredovane UGT1A1.
English: Co-administration of raltegravir with antacids containing divalent metal cations may reduce raltegravir absorption by chelation, resulting in a decrease of raltegravir plasma levels.
Croatian: Istodobna primjena raltegravira s antacidima koji sadrže dvovalentne katione metala može kelacijom smanjiti apsorpciju raltegravira i tako dovesti do sniženja koncentracije raltegravira u plazmi.
English: At the highest dose levels, 400 mg/kg/day in females and 250 mg/kg/day in males, systemic exposure was similar to that at the clinical dose of 1,200 mg once daily.
Croatian: Pri najvišoj dozi od 400 mg/kg/dan kod ženki i 250 mg/kg /dan kod mužjaka, sustavna izloženost bila je slična onoj koja se postiže pri kliničkoj dozi od 1200 mg jedanput na dan.
English: Your doctor will tell you the right dose at each check-up after weighing your child. Be sure to keep your doctor's appointments so you get new dosing information as your child grows.
Croatian: Liječnik će Vam reći točnu dozu pri svakom kontrolnom pregledu, nakon što izvaže dijete.
English: For analysis by prognostic factors, virologic failures were carried forward for percent < 400 and 50 copies/mL.
Croatian: Za analizu prema prognostičkim faktorima, neuspjeli virološki odgovori preneseni su za postotak < 400 i 50 kopija/ml.
English: Tablet core - Microcrystalline cellulose - Hypromellose 2910 - Magnesium stearate - Croscarmellose sodium
Croatian: Jezgra tablete - mikrokristalična celuloza - hipromeloza 2910 - magnezijev stearat - umrežena karmelozanatrij
English: The 100 mg chewable tablet can be divided into equal halves.
Croatian: Tableta za žvakanje od 100 mg može se podijeliti na dvije jednake polovice.
English: Table 5 Efficacy Outcome at Weeks 48 and 240
Croatian: Tablica 5 Ishod djelotvornosti 48. i 240. tjedna
English: BLUE
Croatian: PLAVA
English: tipranavir /ritonavir (raltegravir 400 mg Twice Daily)
Croatian: tipranavir/ritonavir (raltegravir 400 mg dvaput na dan)
English: maraviroc AUC  14 % maraviroc C12hr  10 % maraviroc Cmax ↓ 21 %
Croatian: maravirok AUC  14% maravirok C12h  10% maravirok Cmax ↓ 21%
English: Co-administration of raltegravir with other agents that increase gastric pH (e.g., omeprazole and famotidine) may increase the rate of raltegravir absorption and result in increased plasma levels of raltegravir (see Table 3).
Croatian: Istodobna primjena raltegravira s drugim lijekovima koji povisuju želučani pH (npr. omeprazolom i famotidinom) može povećati stopu apsorpcije raltegravira i dovesti do povišenja koncentracije raltegravira u plazmi (vidjeti Tablicu 3).
English: With respect to the primary efficacy endpoint, the proportion of patients achieving HIV RNA < 40 copies/mL at Week 48 was 472/531(88.9 %) in the group receiving raltegravir 1,200 mg once daily and 235/266 (88.3 %) in the group receiving raltegravir 400 mg twice daily.
Croatian: Što se tiče primarnog ishoda djelotvornosti, udio bolesnika u kojih je u 48. tjednu postignuta koncentracija HIV-RNK < 40 kopija/ml iznosio je 472/531 (88,9%) u skupini koja je primala raltegravir u dozi od 1200 mg jedanput na dan i 235/266 (88,3%) u skupini koja je primala raltegravir u dozi od 400 mg dvaput na dan.
English: Baseline Characteristic HIV-RNA > 100,000 copies/mL
Croatian: HIV-RNK > 100 000 kopija/ml
English: Bring this booklet to your child's appointments.
Croatian: Ponesite ovu knjižicu s uputama za primjenu na sve djetetove liječničke preglede.
English: Uncommon mental disorder, suicide attempt, anxiety, confusional state, depressed mood, major depression, middle insomnia, mood altered, panic attack, sleep disorder, suicidal ideation, suicidal behaviour (particularly in patients with a pre-existing history of psychiatric illness)
Croatian: Psihijatrijski poremećaji često neuobičajeni snovi, insomnia, noćne more, neuobičajeno ponašanje, depresija manje često mentalni poremećaj, pokušaj suicida, anksioznost, stanje konfuzije, depresivno raspoloženje, teški oblik depresije, umjerena insomnia, promjena raspoloženja, napadaj panike, poremećaj spavanja, suicidalne ideacije, suicidalno ponašanje (osobito u bolesnika s psihijatrijskom bolešću u anamnezi)
English: For analysis by prognostic factors, virologic failures were carried forward for percent < 50 and 400 copies/mL.
Croatian: Za analizu prema prognostičkim faktorima, neuspjeli virološki odgovori preneseni su za postotak < 50 i 400 kopija/ml.
English: Mean CD4 Cell Change (95 % CI), cells/mm
Croatian: Srednja vrijednost promjene broja CD4 stanica (95% CI), stanica/mm
English: Co-administration of raltegravir with other agents that increase gastric pH (e.g., omeprazole and famotidine) may increase the rate of raltegravir absorption and result in increased plasma levels of raltegravir (see Table 1).
Croatian: Istodobna primjena raltegravira s drugim lijekovima koji povisuju želučani pH (npr. omeprazolom i famotidinom) može povećati stopu apsorpcije raltegravira i dovesti do povišenja koncentracije raltegravira u plazmi (vidjeti Tablicu 1).
English: CCR5 inhibitors maraviroc (raltegravir 400 mg Twice Daily)
Croatian: Inhibitori CCR5 maravirok (raltegravir 400 mg dvaput na dan)
English: At Week 96, the proportion of patients achieving HIV RNA < 40 copies/mL was 433/531(81.5 %) in the group receiving raltegravir 1,200 mg once daily and 213/266 (80.1 %) in the group receiving raltegravir 400 mg twice daily.
Croatian: Udio bolesnika u kojih je u 96. tjednu postignuta koncentracija HIV-RNK < 40 kopija/ml iznosio je 433/531 (81,5%) u skupini koja je primala raltegravir u dozi od 1200 mg jedanput na dan i 213/266 (80,1%) u skupini koja je primala raltegravir u dozi od 400 mg dvaput na dan.
English: Tablet core - Microcrystalline cellulose - Lactose monohydrate - Calcium phosphate dibasic anhydrous - Hypromellose 2208 - Poloxamer 407 - Sodium stearyl fumarate - Magnesium stearate
Croatian: Jezgra tablete - mikrokristalična celuloza - laktoza hidrat - kalcijev hidrogenfosfat, bezvodni - hipromeloza 2208 - poloksamer 407 - natrijev stearilfumarat - magnezijev stearat
English: A slight increase in incidence of supernumerary ribs, a variant in the normal developmental process, was observed in rat foetuses of dams exposed to raltegravir at approximately 4.4-fold human exposure at the recommended human dose (RHD) based on AUC0-24 hr. No development effects were seen at 3.4-fold human exposure at the RHD.
Croatian: Zapažen je neznatan porast incidencije prekobrojnih rebara, različito od normalnog razvojnog procesa, u fetusa štakora kada je izloženost ženke raltegraviru bila približno 4,4 puta veća od izloženosti u ljudi pri primjeni preporučene doze za ljude (engl. recommended human dose, RHD) izračunate na temelju AUC0-24h.
English: Administration of raltegravir following a low-fat meal decreased AUC and Cmax by 46 % and 52 %, respectively; C12 hr was essentially unchanged.
Croatian: Primjena raltegravira nakon obroka siromašnog mastima dovela je do pada AUC-a za 46% i Cmax za 52%, a C12h se nije bitno promijenio.
English: No dose adjustment required for raltegravir or maraviroc.
Croatian: Nije potrebno prilagođavati dozu raltegravira ili maraviroka.
English: ISENTRESS is also available as a 400 mg tablet for twice daily use in HIV infected adults or children and adolescents at least 25 kg.
Croatian: ISENTRESS je dostupan i u obliku tableta od 400 mg za primjenu dvaput na dan u odraslih ili djece i adolescenata zaraženih HIV-om čija je tjelesna težina najmanje 25 kg.
English: Elimination of raltegravir in vivo in human is primarily through the UGT1A1-mediated glucuronidation pathway.
Croatian: Raltegravir se in vivo u ljudi eliminira prvenstveno putem glukuronidacije u kojoj posreduje enzim UGT1A1.
English: Mean CD4 Cell Change (95 % CI), cells/mm All patients
Croatian: Srednja vrijednost promjene broja CD4 stanica (95% CI), stanica/mm Svi bolesnici
English: Week 48 and Week 96 outcomes from ONCEMRK are shown in Table 4.
Croatian: U Tablici 4 prikazani su ishodi u 48. tjednu i 96. tjednu liječenja u ispitivanju ONCEMRK.
English: ISENTRESS 100 mg granules Raltegravir
Croatian: ISENTRESS 100 mg granule raltegravir
English: How to take Isentress
Croatian: Kako uzimati Isentress
English: • inflammation of liver
Croatian: • zatajenje jetre
English: No dose adjustment required for raltegravir or etravirine.
Croatian: Nije potrebno prilagođavati dozu raltegravira ili etravirina.
English: The orange-banana flavoured chewable tablet is round and pale yellow, marked with the MSD corporate logo on one side and “473” on the other side.
Croatian: Tableta za žvakanje okusa banane i naranče je okrugla i blijedožuta, s logotipom tvrtke MSD na jednoj i oznakom "473" na drugoj strani.
English: • abdominal pain upper; rectal discomfort; constipation; dry mouth; heartburn; pain when swallowing; inflammation of the pancreas; ulcer or sore in stomach or upper intestine; bleeding at anus; stomach discomfort; inflammation of the gums; swollen, red sore tongue
Croatian: • bol u gornjem dijelu trbuha; nelagoda u području završnog dijela debelog crijeva (rektuma); zatvor; suha usta; žgaravica; bol pri gutanju; upala gušterače; čir ili ranice u želucu ili gornjem dijelu crijeva; krvarenje iz čmara (anusa); osjećaj nelagode u želucu; upala zubnog mesa; natečen, crven i bolan jezik
English: (UGT1A1 inhibition)
Croatian: (inhibicija UGT1A1)
English: Chewable tablet
Croatian: Tableta za žvakanje
English: For mean CD4 changes, baselinecarry-forward was used for virologic failures.
Croatian: Za srednje vrijednosti promjene broja CD4 stanica, kod neuspjelog virološkog odgovora preneseni su početni nalazi.
English: One patient experienced drug related clinical adverse reactions of Grade 3 psychomotor hyperactivity, abnormal behaviour and insomnia; one patient experienced a Grade 2 serious drug related allergic rash.
Croatian: Jedan je pedijatrijski bolesnik imao kliničke nuspojave povezane s lijekom: psihomotoričku hiperaktivnost 3. stupnja, neuobičajeno ponašanje i insomniju.
English: ISENTRESS 25 mg chewable tablets ISENTRESS 100 mg chewable tablets
Croatian: ISENTRESS 25 mg tablete za žvakanje ISENTRESS 100 mg tablete za žvakanje
English: Severe and life-threatening skin reactions and allergic reactions have been reported in some patients taking this medicine.
Croatian: U nekih bolesnika koji su uzimali ovaj lijek prijavljeni su slučajevi teških i po život opasnih kožnih i alergijskih reakcija.
English: Ethinyl Estradiol AUC  2 % Ethinyl Estradiol Cmax ↑ 6 % Norelgestromin AUC ↑ 14 % Norelgestromin Cmax ↑ 29 %
Croatian: etinilestradiol AUC  2% etinilestradiol Cmax ↑ 6% norelgestromin AUC ↑ 14% norelgestromin Cmax ↑ 29%
English: The other ingredients are: lactose monohydrate, microcrystalline cellulose, calcium phosphate dibasic anhydrous, hypromellose 2208, poloxamer 407, sodium stearyl fumarate, and magnesium stearate.
Croatian: Drugi sastojci su: laktoza hidrat, mikrokristalična celuloza, kalcijev hidrogenfosfat, bezvodni, hipromeloza 2208, poloksamer 407, natrijev stearilfumarat i magnezijev stearat.
English: What Isentress looks like and contents of the pack The banana flavoured granules for oral suspension is a white to off-white powder that may contain yellow or beige to tan particles in a single-use sachet.
Croatian: Granule za oralnu suspenziju s okusom banane su bijeli do bjelkasti prašak koji može sadržavati čestice žute ili bež do svijetlosmeđe boje, a dolaze u vrećici za jednokratnu primjenu.
English: Uncommon abdominal distention, abdominal pain, diarrhoea, flatulence, nausea, vomiting, dyspepsia gastritis, abdominal discomfort, abdominal pain upper, abdominal tenderness, anorectal discomfort, constipation, dry mouth, epigastric discomfort, erosive duodenitis, eructation, gastroesophageal reflux disease, gingivitis, glossitis, odynophagia, pancreatitis acute, peptic ulcer, rectal haemorrhage
Croatian: Poremećaji probavnog sustava često manje često distenzija abdomena, bol u abdomenu, dijareja, flatulencija, mučnina, povraćanje, dispepsija gastritis, nelagoda u abdomenu, bol u gornjem abdomenu, osjetljivost abdomena, nelagoda u anorektalnom području, konstipacija, suha usta, nelagoda u epigastriju, erozivni duodenitis, eruktacija, gastroezofagealna refluksna bolest, gingivitis, glositis, odinofagija, akutni pankreatitis, peptički ulkus, krvarenje iz rektuma
English: Achieved ≥1 log10 HIV RNA drop from baseline or <400 copies/mL
Croatian: Postigli smanjenje HIV-RNK za ≥ 1 log10 od početnih vrijednosti ili < 400 kopija/ml Postigli < 50 HIV-RNK kopija/ml
English: 60 sachets, two 1 mL, two 3 mL and two 10 mL oral dosing syringes and 2 mixing cups.
Croatian: 60 vrećica, dvije štrcaljke od 1 ml, dvije štrcaljke od 3 ml i dvije štrcaljke od 10 ml za doziranje kroz usta te 2 čaše za miješanje.
English: Raltegravir 1,200 mg QD and raltegravir 400 mg BID were administered with emtricitabine (+) tenofovir disoproxil fumarate.
Croatian: Raltegravir u dozi od 1200 mg jedanput na dan i raltegravir u dozi od 400 mg dvaput na dan primjenjivali su se s emtricitabinom (+) tenofovirdizoproksilfumaratom.
English: Read the package leaflet and booklet before use.
Croatian: Prije uporabe pročitajte uputu o lijeku i knjižicu s uputama za primjenu.
English: Raltegravir at concentrations of 31  20 nM resulted in 95 % inhibition (IC95) of HIV-1 replication (relative to an untreated virus-infected culture) in human T-lymphoid cell cultures infected with the cell-line adapted HIV-1 variant H9IIIB.
Croatian: U kulturama humanih T-limfoidnih stanica, inficiranih sojem H9IIIB virusa HIV-1 prilagođenim za staničnu liniju, raltegravir je u koncentracijama od 31  20 nM izvršio 95%-tnu inhibiciju (IC95) replikacije virusa HIV-1 (u odnosu na netretiranu, virusom inficiranu kulturu).
English: • This product does not require any special storage conditions.
Croatian: • Lijek ne zahtijeva posebne uvjete čuvanja.
English: Uncommon cachexia, diabetes mellitus, dyslipidaemia, hypercholesterolaemia, hyperglycaemia, hyperlipidaemia, hyperphagia, increased appetite, polydipsia, body fat disorder
Croatian: Poremećaji metabolizma i prehrane često smanjen apetit manje često kaheksija, diabetes mellitus, dislipidemija, hiperkolesterolemija, hiperglikemija, hiperlipidemija, hiperfagija, pojačan apetit, polidipsija, poremećaj masnog tkiva
English: One carton contains 60 sachets, two 1 mL, two 3 mL and two 10 mL oral dosing syringes and 2 mixing cups.
Croatian: Jedna kutija sadrži 60 vrećica, dvije štrcaljke od 1 ml, dvije štrcaljke od 3 ml i dvije štrcaljke od 10 ml za doziranje kroz usta te 2 čaše za miješanje.
English: Co-administration of raltegravir with aluminium and/or magnesium containing antacids is not recommended.
Croatian: Istodobna primjena raltegravira s antacidima koji sadrže aluminij i/ili magnezij se ne preporučuje.
English: Chewable tablet 25 mg - Hydroxypropyl cellulose - Sucralose - Saccharin sodium - Sodium citrate dihydrate - Mannitol - Monoammonium glycyrrhizinate - Sorbitol (E420) - Fructose - Banana flavour - Orange flavour - Masking flavour - Aspartame (E951)
Croatian: Tableta za žvakanje od 25 mg - hidroksipropilceluloza - sukraloza - saharinnatrij - natrijev citrat dihidrat - manitol - amonijev glicirizat - sorbitol (E420) - fruktoza - aroma banane - aroma naranče - aroma za maskiranje okusa - aspartam (E951) - krospovidon, tipa
English: Grade 2-4 creatine kinase laboratory abnormalities were observed in patients treated with raltegravir.
Croatian: U bolesnika koji su liječeni raltegravirom opažena su odstupanja u laboratorijskim nalazima kreatin kinaze 2. do 4. stupnja.
English: METHOD AND ROUTES OF ADMINISTRATION
Croatian: Upravljanje vozilima i strojevima
English: H2 BLOCKERS AND PROTON PUMP INHIBITORS omeprazole (raltegravir 400 mg Twice Daily)
Croatian: BLOKATORI H2 RECEPTORA I INHIBITORI PROTONSKE PUMPE omeprazol (raltegravir 400 mg dvaput na dan)
English: 14 to less than 20 † 10 mL (100 mg) twice daily 1 x 100 mg twice daily 20 to less than 25
Croatian: 8 ml (80 mg) dvaput na dan 3 x 25 mg dvaput na dan od 14 do manje od 20 † 10 ml (100 mg) dvaput na dan 1 x 100 mg dvaput na dan od 20 do manje od 25
English: Table 3 Efficacy Outcome at Weeks 48 and 240
Croatian: Tablica 3 Ishod djelotvornosti 48. i 240. tjedna
English: Uncommon hot flush, hypertension
Croatian: Krvožilni poremećaji manje često navale vrućine, hipertenzija
English: Results 48-week and 96-week analyses
Croatian: Rezultati analiza 48.i 96. tjedna
English: Geometric mean (%CV AUC0-12hr (μM●hr)
Croatian: Geometrijska srednja vrijednost (%CV AUC 0-12h (μM●h)
English: 200 mg twice daily
Croatian: 200 mg dvaput na dan
English: OPIOID ANALGESICS methadone (raltegravir 400 mg Twice Daily)
Croatian: OPIOIDNI ANALGETICI metadon (raltegravir 400 mg dvaput na dan)
English: 25 mg chewable tablets: Each chewable tablet contains 25 mg of raltegravir (as potassium).
Croatian: Tableta za žvakanje od 25 mg: Jedna tableta za žvakanje sadrži 25 mg raltegravira (u obliku raltegravirkalija).
English: 25 mg chewable tablets:
Croatian: Tablete za žvakanje od 25 mg:
English: In this study, administration of the chewable tablet with a high fat meal led to an average 6 % decrease in AUC, 62 % decrease in Cmax, and 188 % increase in C12 hr compared to administration in the fasted state.
Croatian: U ovom je ispitivanju nakon primjene tablete za žvakanje, uz punomastan obrok, dovela do smanjenja AUC-a za 6%, a Cmax je smanjen za 62%, dok je C12 h bio 188% veći u usporedbi s primjenom natašte.