FrancophonIA/ELRC3.0 huggingface dataset:
English: Lopinavir/ ritonavir 800/200 mg per day N=346
Slovenian: lopinavir/ ritonavir 800 mg/200 mg/dan N=346
English: Tell your doctor if you take: - Phenobarbital, phenytoin (to prevent seizures) - Dexamethasone (corticosteroid) - Efavirenz (HIV infection) - Boceprevir (hepatitis C infection) - Rifapentine, rifabutin (medicines to treat some infections such as tuberculosis) - Saquinavir (HIV infection).
Slovenian: Povejte svojemu zdravniku, če jemljete: - fenobarbital, fenitoin (za preprečevanje epileptičnih napadov) - deksametazon (kortikosteroid) - efavirenz (za zdravljenje okužbe s HIV) - boceprevir (za zdravljenje okužbe s hepatitisom C) - rifapentin, rifabutin (zdravili za zdravljenje nekaterih okužb, kot je tuberkuloza) - sakvinavir (za zdravljenje okužbe s HIV).
English: Dexamethasone may decrease plasma concentrations of darunavir.
Slovenian: Deksametazon lahko zmanjša plazemske koncentracije darunavirja.
English: In addition, pharmacokinetic modeling and simulation of darunavir exposures in paediatric patients across the ages of 3 to < 18 years confirmed the darunavir exposures as observed in the clinical studies and allowed the identification of weight-based darunavir/ritonavir once daily dosing regimens for paediatric patients weighing at least 15 kg that are either ART-naïve or treatment-experienced paediatric patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Slovenian: Farmakokinetični model in posnemanje izpostavljenosti darunavirju pri pediatričnih bolnikih starih od 3 do < 18 let sta potrdila izpostavljenost darunavirju, opaženo v kliničnih preskušanjih in na osnovi telesne mase določila odmerjanje darunavirja/ritonavirja enkrat na dan pri pediatričnih bolnikih s telesno maso najmanj 15 kg, predhodno zdravljenih ali nezdravljenih z ART in so brez z rezistenco za darunavir povezanih mutacij (DRV-RAM) * in imajo plazemsko koncentracijo HIV-1 RNK < 100,000 kopij/ml in število CD4+ celic ≥ 100 celic x 10
English: Indinavir 800 mg twice daily indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ #darunavir AUC ↑ 24% darunavir Cmin ↑ 44% #darunavir Cmax ↑ 11%
Slovenian: indinavir 800 mg dvakrat na dan indinavir AUC ↑ 23 % indinavir Cmin ↑ 125 % indinavir Cmax ↔ #darunavir AUC ↑ 24 % darunavir Cmin ↑ 44 % #darunavir Cmax ↑ 11 %
English: This dose must not exceed the recommended adult dose, which is 600 milligram darunavir together with 100 milligram of ritonavir two times per day or 800 milligram darunavir together with 100 milligram ritonavir once a day.
Slovenian: Ta odmerek ne sme preseči priporočenega odmerka za odrasle, ki je 600 miligramov darunavirja, skupaj s 100 miligrami ritonavirja, dvakrat na dan ali 800 miligramov darunavirja, skupaj s 100 miligrami ritonavirja, enkrat na dan.
English: HIV-1 RNA < 50 copies/ml a b median CD4+ cell count change from baseline (x 10
Slovenian: HIV-1 RNK < 50 kopij/ml a b mediana sprememba števila CD4+ celic od začetka (x 10
English: ART-experienced paediatric patients from the age of 6 to < 18 years, and weighing at least 20 kg
Slovenian: Pediatrični bolniki, predhodno zdravljeni z ART, stari od 6 do < 18 let in s telesno maso najmanj 20 kg
English: Co-administration of boosted daruanvir with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Slovenian: Sočasna uporaba darunavirja z navedenimi antikoagulanti lahko zveča njihove koncentracije, kar lahko poveča tveganje za krvavitve.
English: Rash occurred more commonly in treatment-experienced patients receiving regimens containing darunavir/ritonavir + raltegravir compared to patients receiving darunavir/ritonavir without raltegravir or raltegravir without darunavir (see section 4.8).
Slovenian: Pri bolnikih z izkušnjami s protiretrovirusnim zdravljenjem, ki so prejemali darunavir/ritonavir skupaj z raltegravirjem, se je izpuščaj pojavljal pogosteje kot pri bolnikih, ki so prejemali darunavir/ritonavir brez raltegravirja ali raltegravir brez darunavirja (glejte poglavje 4.8).
English: The metabolism of alfentanil is mediated via CYP3A, and may as such be inhibited by boosted darunavir.
Slovenian: Presnova alfentanila poteka preko CYP3A in jo lahko zavira okrepljeni darunavir.
English: HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir† Lopinavir/ritonavir
Slovenian: Zaviralci proteaze (PI) - z ritonavirjem v majhnem odmerku† lopinavir/ritonavir
English: Due to an increase in the unbound darunavir plasma concentrations, darunavir should be used with caution in patients with mild or moderate hepatic impairment (see sections 4.2, 4.3 and 5.2).
Slovenian: Zaradi zvišanja plazemske koncentracije nevezanega darunavirja je treba pri bolnikih z blago do zmerno okvaro jeter darunavir uporabljati previdno (glejte poglavja 4.2, 4.3 in 5.2).
English: with darunavir/cobicistat 800/150 mg
Slovenian: § s kombinacijo darunavir/kobicistat 800/150 mg
English: Co-administration is expected to reduce plasma concentrations of darunavir, ritonavir and cobicistat, which could lead to loss of therapeutic effect and possible development of resistance (see sections 4.4 and 4.5).
Slovenian: Pri sočasnem dajanju je pričakovati zmanjšanje plazemske koncentracije darunavirja, ritonavirja in kobicistata, kar lahko vodi v izgubo terapevtskega učinka in razvoj odpornosti (glejte poglavji 4.4 in 4.5).
English: Darunavir co-administered with low dose ritonavir and etravirine 200 mg twice daily can be used without dose adjustments.
Slovenian: Darunavir se lahko skupaj z majhnim odmerkom ritonavirja in z 200 mg etravirina dvakrat na dan uporablja brez prilagajanja odmerkov.
English: For information on cobicistat pharmacokinetic properties, consult the cobicistat Summary of Product Characteristics.
Slovenian: Za podatke o farmakokinetičnih lastnostih kobicistata preberite Povzetek glavnih značilnosti zdravila za kobicistat.
English: Darunavir Mylan must always be given orally with low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products.
Slovenian: Zdravilo Darunavir Mylan je treba vedno dajati peroralno skupaj z majhnim odmerkom ritonavirja kot učinkovino za farmakokinetično okrepitev in v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: Darunavir/ritonavir N=80
Slovenian: Izidi v 48. tednu darunavir/ritonavir N=80
English: Amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine to treat certain heart disorders e.g. abnormal heart beat
Slovenian: zdravljenje migrenskih glavobolov amiodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin zdravljenje določenih bolezni srca, npr. motenj srčnega ritma
English: Concomitant use of colchicine and boosted darunavir may increase the exposure to colchicine.
Slovenian: Pri sočasni uporabi kolhicina in okrepljenega darunavirja, se lahko zveča izpostavljenost kolhicinu.
English: - Take darunavir always together with 150 milligram of cobicistat or 100 milligram of ritonavir.
Slovenian: - Darunavir vzemite vedno skupaj s 150 miligrami kobicistata ali 100 miligrami ritonavirja.
English: kidney or lung] - heart attack, slow heart beating, palpitations - visual disturbance - chills, feeling abnormal - a feeling of confusion or disorientation, altered mood, restlessness - fainting, epileptic fits, changes or loss of taste - mouth sores, vomiting blood, inflamation of the lips, dry lips, coated tongue - running nose - skin lesions, dry skin - stiffness of muscles or joints, joint pain with or without inflammation - changes in some values of your blood cells or chemistry.
Slovenian: - stanje zmedenosti ali dezorientacije, spremembe razpoloženja, nemir - omedlevica, epileptični napadi, spremembe ali izguba okusa - razjede v ustih, bruhanje krvi, vnetje ustnic, suhe ustnice, obložen jezik - izcedek iz nosu - razjede na koži, suha koža - okorelost mišic ali sklepov, bolečina v sklepih z vnetjem ali brez vnetja - spremembe v vrednostih nekaterih krvnih celic ali kemijskih parametrov.
English: Based on theoretical considerations boosted darunavir may increase the exposure to glecaprevir and pibrentasvir.
Slovenian: glekaprevir/pibrentasvir Glede na teoretična izhodišča je mogoče pričakovati, da lahko okrepljeni darunavir zveča izpostavljenost glekaprevirju in pibrentasvirju.
English: Plasma concentrations of these medicinal products may be increased when co-administered with darunavir with low dose ritonavir, resulting in reduced serum cortisol concentrations.
Slovenian: Koncentracije teh zdravil v plazmi se lahko pri sočasnem dajanju z darunavirjem skupaj z majhnim odmerkom ritonavirja zvečajo, kar povzroči zmanjšanje koncentracije kortizola v serumu.
English: Atorvastatin 10 mg once daily atorvastatin AUC ↑ 3-4 fold atorvastatin Cmin ↑ ≈5.5-10 fold atorvastatin Cmax ↑ ≈2 fold #darunavir/ritonavir atorvastatin AUC ↑ 290% Ω
Slovenian: atorvastatin 10 mg enkrat na dan atorvastatin AUC ↑ 3-4-krat atorvastatin Cmin ↑ ≈5,5-10-krat atorvastatin Cmax ↑ ≈2-krat darunavir/ritonavir atorvastatin AUC ↑ 290 %
English: Last Observation Carried Forward imputation
Slovenian: Pripisano: prenos zadnjega opažanja.
English: Amlodipine Diltiazem Felodipine Nicardipine Nifedipine Verapamil
Slovenian: ZAVIRALCI KALCIJEVIH KANALČKOV amlodipin diltiazem felodipin nikardipin nifedipin verapamil
English: - Darunavir Mylan 75 milligram and 150 milligram tablets have been developed for use in children, but can also be used in adults in some cases.
Slovenian: - 75-miligramske in 150-miligramske tablete zdravila Darunavir Mylan so namenjene uporabi pri otrocih, vendar jih v nekaterih primerih lahko uporabljajo tudi odrasli.
English: - Swallow the tablet with a drink such as water or milk.
Slovenian: - Tableto pogoltnite s pijačo, kot je voda ali mleko.
English: Boosted darunavir can be coadministered with H2-receptor antagonists without dose adjustments.
Slovenian: Okrepljeni darunavir lahko uporabljamo sočasno z antagonisti receptorjev H2, brez prilagajanja odmerka.
English: tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% #darunavir AUC ↑ 21% darunavir Cmin ↑ 24% #darunavir Cmax ↑ 16% (↑ tenofovir from effect on MDR-1 transport in the renal tubules)
Slovenian: tenofovir AUC ↑ 22 % tenofovir Cmin ↑ 37 % tenofovir Cmax ↑ 24 % #darunavir AUC ↑ 21 % darunavir Cmin ↑ 24 % #darunavir Cmax ↑ 16 % (↑ koncentracij tenofovirja zaradi učinka na MDR-1 transport v ledvičnih tubulih)
English: - Atorvastatin, pravastatin, rosuvastatin (to lower cholesterol levels).
Slovenian: - atorvastatin, pravastatin, rosuvastatin (za zmanjševanje vrednosti holesterola); lahko se zveča tveganje za poškodbo mišic.
English: Patients co-infected with hepatitis B and/or hepatitis C virus Among 1,968 treatment-experienced patients receiving darunavir co-administered with ritonavir 600/100 mg twice daily, 236 patients were co-infected with hepatitis B or C. Co-infected patients were more likely to have baseline and treatment emergent hepatic transaminase elevations than those without chronic viral hepatitis (see section 4.4).
Slovenian: Bolniki, sočasno okuženi z virusom hepatitisa B in/ali virusom hepatitisa C Med 1.968 bolniki, predhodno zdravljeni s protiretrovirusnimi zdravili in so prejemali darunavir skupaj z ritonavirjem (600 mg/100 mg dvakrat na dan), jih je bilo 236 okuženih tudi s hepatitisom B ali C. Pri bolnikih s sočasno okužbo je povišanje koncentracij jetrnih transaminaz bolj verjetno (pred zdravljenjem in kot posledica zdravljenja), kot pri bolnikih, ki nimajo kroničnega virusnega hepatitisa (glejte poglavje 4.4).
English: Darunavir is used to treat adults and children (3 years of age and above, at least 40 kilograms body weight) who are infected by HIV and - who have not used antiretroviral medicines before.
Slovenian: Darunavir uporabljamo za zdravljenje odraslih in otrok (starih 3 leta ali starejših in s telesno maso najmanj 40 kg), ki so okuženi z virusom HIV in - še niso prejemali nobenega drugega protiretrovirusnega zdravila.
English: OR - 600 milligram darunavir (2 tablets containing 300 milligram of darunavir or 1 tablet containing 600 milligram of darunavir) together with 100 milligram ritonavir twice daily.
Slovenian: ALI - 600 miligramov darunavirja (dve tableti po 300 miligramov darunavirja ali ena tableta po 600 miligramov darunavirja) skupaj s 100 miligrami ritonavirja dvakrat na dan.
English: Renal impairment No dose adjustment is required in patients with renal impairment (see sections 4.4 and 5.2).
Slovenian: Pri bolnikih z okvaro ledvic prilagajanje odmerka ni potrebno (glejte poglavji 4.4 in 5.2).
English: Your child's doctor will determine the appropriate dosing regimen for your child. - The child must take darunavir with food.
Slovenian: Otrokov zdravnik bo določil najprimernejši odmerek za vašega otroka.
English: HIV Protease inhibitors (PIs) - without additional co-administration of low dose ritonavir Atazanavir
Slovenian: Zaviralci proteaze (PI) - brez sočasne uporabe majhnega odmerka ritonavirja atazanavir
English: You must eat a meal or a snack within 30 minutes prior to taking your darunavir and cobicistat or ritonavir.
Slovenian: 30 minut preden vzamete darunavir in kobicistat ali ritonavir morate pojesti obrok ali prigrizek.
English: Combinations with optimised background regimen (OBRs) other than ≥ 2 NRTIs have not been studied in this population.
Slovenian: Pri tej populaciji so preučevali samo kombinacije z optimirano osnovno shemo (OBR) z ≥ 2 NRTIji.
English: Boosted darunavir can be expected to increase the plasma concentrations of calcium channel blockers.
Slovenian: Pričakovati je, da okrepljeni darunavir zveča plazemske koncentracije zaviralcev kalcijevih kanalčkov.
English: Concentrations of these medicinal products may be increased when co-administered with darunavir with low dose ritonavir resulting in the potential for increased adverse events usually associated with these agents.
Slovenian: Koncentracije teh zdravil se lahko pri sočasnem dajanju z darunavirjem skupaj z majhnim odmerkom ritonavirja zvečajo, kar lahko zveča možnost za neželene učinke, ki se običajno pojavljajo pri uporabi teh zdravil.
English: Concomitant use of darunavir coadministered with low dose ritonavir and these antidepressants may increase concentrations of the antidepressant.
Slovenian: Sočasna uporaba darunavirja z majhnim odmerkom ritonavirja in z navedenimi antidepresivi lahko zveča koncentracije antidepresivov.
English: According to the TLOVR non-virologic failure censored algorithm 24 (30.0%) patients experienced virological failure, of which 17 (21.3%) patients were rebounders and 7 (8.8%) patients were nonresponders.
Slovenian: Glede na vrednosti izračunane s TLOVR algoritmom je bilo zdravljenje pri 24 (30,0 %) bolnikih virološko neuspešno.
English: The dose of cobicistat to be used with Darunavir has not been established in this patient population.
Slovenian: Odmerka kobicistata za uporabo z darunavirjem pri tej populaciji niso določili.
English: Reproductive system and breast disorders Uncommon erectile dysfunction, gynaecomastia General disorders and administration site conditions Common
Slovenian: Motnje reprodukcije in dojk občasni erektilna disfunkcija, ginekomastija
English: For bottles: Once opened, use within 90 days.
Slovenian: Za plastenke: Po odprtju porabiti v 90 dneh.
English: Concomitant use of darunavir/ritonavir and darunavir/cobicistat with lopinavir/ritonavir, rifampicin and herbal products containing St John's wort, Hypericum perforatum, is contraindicated (see section 4.5).
Slovenian: Sočasna uporaba učinkovin darunavir/ritonavir in darunavir/kobicistat z učinkovinami lopinavir/ritonavir, rifampicin in zdravil rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum), je kontraindicirana (glejte poglavje 4.5).
English: ethinylestradiol Cmax  14% € with darunavir/cobicistat ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindrone AUC ↓ 14% norethindrone Cmin ↓ 30% norethindrone Cmax ↔ β with darunavir/ritonavir
Slovenian: etinilestradiol Cmin ND etinilestradiol Cmax  14 % € s kombinacijo darunavir/kobicistat ethinilestradiol AUC ↓ 44 % β ethinilestradiol Cmin ↓ 62 % β ethinilestradiol Cmax ↓ 32 % β noretindron AUC ↓ 14 % β noretindron Cmin ↓ 30 % β noretindron Cmax ↔ β β s kombinacijo darunavir/ritonavir
English: Reproductive system and breast disorders Uncommon gynaecomastia*
Slovenian: Motnje reprodukcije in dojk občasni ginekomastija*
English: When administered concomitantly with darunavir and low dose ritonavir, the patient's tolerability of bosentan should be monitored.
Slovenian: Ob sočasni uporabi z darunavirjem in majhnim odmerkom ritonavirja je treba spremljati bolnikovo prenašanje bosentana.
English: How to take Darunavir Mylan
Slovenian: Kako jemati zdravilo Darunavir Mylan
English: What Darunavir Mylan looks like and contents of the pack
Slovenian: Izgled zdravila Darunavir Mylan in vsebina pakiranja
English: Co-administration of boosted darunavir and amiodarone, bepridil, dronedarone, ivabradine, quinidine, or ranolazine is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba okrepljenega darunavirja z amiodaronom, bepridilom, dronedaronom, ivabradinom, kinidinom ali ranolazinom je kontraindicirana (glejte poglavje 4.3).
English: Do not combine darunavir with products that contain St John's wort (Hypericum perforatum).
Slovenian: Darunavirja ne smete jemati sočasno z zdravili rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum).
English: These results were confirmed in the analysis of data at 96 weeks of treatment in the TITAN trial, with 60.4% of patients in the darunavir/ritonavir arm having HIV-1 RNA < 50 copies/ml at week 96 compared to 55.2% in the lopinavir/ritonavir arm [difference: 5.2%, 95% CI (-2.8; 13.1)].
Slovenian: < 50 kopij/ml HIV-1 RNK je imelo 60,4 % bolnikov v kraku študije z darunavirjem/ritonavirjem, v primerjavi s 55,2 % v kraku študije z lopinavirjem/ritonavirjem [razlika: 5,2 %, 95 IZ (-2,8-13,1)].
English: HDPE bottle pack with a PP screw cap containing 30, 60, 90 tablets.
Slovenian: HDPE plastenka s polipropilensko (PP) navojno zaporko s po 30, 60, 90 filmsko obloženimi tabletami.
English: Pravastatin 40 mg single dose pravastatin AUC ↑ 81%¶
Slovenian: pravastatin enkratni odmerek 40 mg pravastatin AUC ↑ 81 %¶ pravastatin Cmin ND pravastatin Cmax ↑ 63 %
English: Darunavir must be taken in combination with a low dose of ritonavir and other anti-HIV medicines.
Slovenian: Darunavir je treba jemati skupaj z majhnimi odmerki ritonavirja in drugimi zdravili proti okužbi s HIV.
English: Darunavir co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection.
Slovenian: Darunavir je v kombinaciji z majhnim odmerkom ritonavirja in z drugimi protiretrovirusnimi zdravili indiciran za zdravljenje bolnikov okuženih z virusom humane imunske pomanjkljivosti (HIV-1).
English: Darunavir/ritonavir N=12
Slovenian: Izidi v 48. tednu darunavir/ritonavir n=12
English: copies/ml at the week-8; rebound: HIV-1 RNA < 50 copies/ml followed by confirmed HIV-1 RNA to ≥ 400 copies/ml or confirmed > 1 log10 HIV-1 RNA increase from the nadir; discontinuations with HIV-1 RNA ≥ 400 copies/ml at last visit b IAS-USA lists c In GS-US216-130 baseline phenotype was not available
Slovenian: Virološki neuspeh zdravljenja je bil opredeljen kot: brez supresije: zmanjšanje koncentracije HIV-1 RNA za < 1 log10 od izhodišča in ≥ 50 kopij/ml po 8 tednih zdravljenja, potrjeno pri naslednjem obisku; povratni učinek: koncentracija HIV-1 RNA < 50 kopij/ml s kasnejšim potrjenim zvišanjem koncentracije HIV-1 RNA na ≥ 400 kopij/ml ali s potrjenim zvišanjem koncentracije HIV-1 RNA za > 1 log10 od najnižje vrednosti; prekinitve s koncentracijo HIV-1 RNA ≥ 400 kopij/ml pri zadnjem b po seznamih IAS-USA (International AIDS Society-USA)
English: See the Summary of Product Characteristics for darunavir 75 mg, 150 mg, 300 mg or 600 mg tablets.
Slovenian: Glejte povzetke glavnih značilnosti zdravil za 75 mg, 150 mg, 300 mg ali 600 mg filmsko obložene tablete z darunavirjem.
English: When darunavir is coadministered with a drospirenone-containing product, clinical monitoring is recommended due to the potential for hyperkalaemia.
Slovenian: Pri sočasni uporabi darunavirja z zdravili, ki vsebujejo drospirenon, je priporočljivo klinično spremljanje bolnika zaradi možne hiperkaliemije.
English: Blister carton 480 film-coated tablets 480 x 1 film-coated tablets
Slovenian: Škatla s pretisnimi omoti 480 filmsko obloženih tablet 480 x 1 filmsko obložena tableta
English: Postpartum (6-12 weeks) (n=16)
Slovenian: Obdobje po porodu (6-12 tednov) (n=16)
English: Each film-coated tablet contains 75 mg of darunavir.
Slovenian: Ena filmsko obložena tableta vsebuje 75 mg darunavirja.
English: Each tablet contains 75 milligrams of darunavir.
Slovenian: Ena tableta vsebuje 75 miligramov darunavirja.
English: sodium starch glycolate, hypromellose, magnesium stearate.
Slovenian: krospovidon, natrijev karboksimetilškrob, hipromeloza, magnezijev stearat.
English: Rare headache, peripheral neuropathy, dizziness lethargy, paraesthesia, hypoaesthesia, dysgeusia, disturbance in attention, memory impairment, somnolence syncope, convulsion, ageusia, sleep phase rhythm disturbance
Slovenian: Bolezni živčevja pogosti glavobol, periferna nevropatija, omotica občasni letargija, parestezija, hipestezija, disgevzija, motnje pozornosti, motnje spomina, zaspanost redki sinkopa, konvulzije, agevzija, motnje spalnega ritma
English: Number of subjects with virologic failure and paired baseline/endpoint phenotypes, showing loss of susceptibility to PIs at endpoint compared to baseline, n/N PI darunavir amprenavir atazanavir indinavir lopinavir saquinavir tipranavir a TLOVR non-VF censored algorithm based on HIV-1 RNA < 50 copies/ml, except for TITAN (HIV-1 RNA <
Slovenian: Število preiskovancev z virološkim neuspehom zdravljenja a in podatki o fenotipu, ki kažejo odpornost na zaviralce proteaz (PI) ob zaključku zdravljenjac, n/N HIV PI darunavir amprenavir atazanavir indinavir lopinavir sakvinavir tipranavir a
English: Rifapentine and rifampicin are strong CYP3A inducers and have been shown to cause profound decreases in concentrations of other protease inhibitors, which can result in virological failure and resistance development (CYP450 enzyme induction).
Slovenian: Dokazano je bilo, da povzročata precejšnje zmanjšanje koncentracij drugih zaviralcev proteaz, kar tega lahko vodi v virološko neuspešnost in razvoj rezistence (indukcija CYP450).
English: 30 film-coated tablets 60 film-coated tablets 90 film-coated tablets
Slovenian: 30 filmsko obloženih tablet 60 filmsko obloženih tablet 90 filmsko obloženih tablet
English: This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodiumfree'.
Slovenian: Zdravilo Darunavir Mylan vsebuje natrij To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na odmerek, kar v bistvu pomeni ''brez natrija''.
English: Concomitant use of sildenafil or tadalafil for the treatment of pulmonary arterial hypertension and darunavir co-administered with low dose ritonavir may increase plasma concentrations of sildenafil or tadalafil.
Slovenian: Pri sočasni uporabi sildenafila ali tadalafila (za zdravljenje pljučne arterijske hipertenzije) in darunavirja v kombinaciji z majhnim odmerkom ritonavirja lahko pride do zvečanja plazemskih koncentracij sildenafila ali tadalafila.
English: - Take your other HIV medicines used in combination with darunavir and ritonavir as recommended by your doctor.
Slovenian: - Po navodilih zdravnika, vzemite tudi ostala zdravila proti HIV, ki jih uporabljate v kombinaciji z darunavirjem in ritonavir.
English: Concomitant use of salmeterol and boosted darunavir may increase plasma concentrations of salmeterol.
Slovenian: Pri sočasni uporabi salmeterola in okrepljenega darunavirja lahko pride do zvečanja plazemskih koncentracij salmeterola.
English: Darunavir must be taken in combination with a low dose of cobicistat or ritonavir and other anti-HIV medicines.
Slovenian: Darunavir je treba jemati skupaj z majhnimi odmerki kobicistata ali ritonavirja in drugimi zdravili proti okužbi s HIV.