FrancophonIA/ELRC3.0 huggingface dataset:
English: Although there were more fractures in the Relvar Ellipta groups compared with the vilanterol 22 micrograms group, fractures typically associated with corticosteroid use (e.g., spinal compression/thoracolumbar vertebral fractures, hip and acetabular fractures) occurred in <1% of the Relvar Ellipta and vilanterol treatment arms.
Danish: Selvom der var flere frakturer i Relvar Ellipta-grupperne sammenlignet med gruppen, der fik vilanterol 22 mikrogram, var forekomsten af de frakturer, der typisk er forbundet med brug af kortikosteroider (f.eks. spinale kompressionsfrakturer/torakolumbale vertebrale frakturer, hofte- og hofteskålsfrakturer), <1 % i behandlingsarmene med Relvar Ellipta og vilanterol.
English: • awareness of heart beat (palpitations)
Danish: • hjertebanken (palpitationer)
English: Asthma is a serious, long term lung disease where the muscles surrounding the smaller airways become tight (bronchoconstriction) and swollen and irritated (inflammation).
Danish: Astma er en alvorlig, langvarig lungesygdom, hvor musklerne omkring de små luftveje trækker sig sammen og strammes og dermed besværliggør luftpassage (bronkokonstriktion) samtidigt med, at luftvejene er hævede og irriterede (inflammation).
English: The safety and efficacy of fluticasone furoate/vilanterol in children under the age of 12 years has not yet been established.
Danish: Sikkerheden og virkningen af fluticasonfuroat/vilanterol hos børn under 12 år er endnu ikke klarlagt.
English: A decision must be made whether to discontinue breast-feeding or to discontinue fluticasone furoate/vilanterol therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Danish: Det skal besluttes, om amning eller behandling med fluticasonfuroat/vilanterol skal ophøre, idet der tages højde for fordelene ved amning for barnet i forhold til de terapeutiske fordele for moderen.
English: In peripheral blood mononuclear cells from subjects with COPD, a larger anti-inflammatory effect was seen in the presence of the combination of fluticasone furoate/vilanterol compared with fluticasone furoate alone at concentrations achieved with clinical doses.
Danish: I de mononukleære celler i perifert blod hos personer med KOL, blev der set en større antiinflamatorisk virkning i forbindelse med kombinationen af fluticasonfuroat/vilanterol sammenlignet med fluticasonfuroat alene ved koncentrationer opnået med kliniske doser.
English: Hypersensitivity reactions including anaphylaxis, angioedema, rash, and urticaria.
Danish: Overfølsomhedsreaktioner, herunder anafylaksi, angioødem, udslæt og urticaria
English: *FF/VI = fluticasone furoate/vilanterol
Danish: *FF/VI = fluticasonfuroat/vilanterol
English: A clinical pharmacology study of fluticasone furoate/vilanterol showed that severe renal impairment (creatinine clearance <30mL/min) did not result in significantly greater exposure to fluticasone furoate or vilanterol or more marked corticosteroid or beta2-agonist systemic effects compared with healthy subjects.
Danish: Et klinisk farmakologisk studie med fluticasonfuroat/vilanterol viste, at svær nyreinsufficiens (kreatininclearance < 30 ml/min) ikke resulterede i signifikant større eksponering af fluticasonfuroat eller vilanterol eller i en mere udtalt systemisk virkning af kortikosteroid eller beta2-agonist end hos raske personer.
English: Interaction with P-glycoprotein inhibitors
Danish: Interaktion med P-glykoproteinhæmmere
English: In inhalation studies in rabbits, vilanterol trifenatate caused effects similar to those seen with other beta2 agonists (cleft palate, open eyelids, sternebral fusion and limb flexure/malrotation).
Danish: I inhalationsstudier med kaniner medførte vilanteroltrifenatat effekter, der lignede de effekter, der ses med andre beta2-agonister (ganespalte, åbne øjenlåg, sammenvoksning ved sternum og abnormt bøjede lemmer/malrotation).
English: The 184/22 micrograms strength is used to treat asthma in adults and adolescents aged 12 years and older.
Danish: Styrken på 184/22 mikrogram anvendes til behandling af astma hos voksne og unge fra 12 år og derover.
English: Fluticasone furoate and vilanterol are both rapidly cleared by extensive first pass metabolism mediated by the liver enzyme CYP3A4.
Danish: Både fluticasonfuroat og vilanterol elimineres hurtigt via omfattende first pass-metabolisme, medieret af leverenzymet CYP3A4.
English: Don't use this medicine if you are breastfeeding unless your doctor tells you that you can.
Danish: Brug ikke dette lægemiddel hvis du ammer, medmindre din læge siger du kan.
English: There is no additional benefit of the 184/22 micrograms dose compared to the 92/22 micrograms dose and there is a potential increased risk of pneumonia and systemic corticosteroid-related adverse reactions (see sections 4.4 and 4.8).
Danish: Der er ingen yderligere fordel ved dosen på 184/22 mikrogram sammenlignet med dosen på 92/22 mikrogram, og der er en potentielt øget risiko for pneumoni og bivirkninger relateret til kortikosteroiders systemiske virkninger (se pkt.
English: Relvar Ellipta contains two active substances: fluticasone furoate and vilanterol.
Danish: Relvar Ellipta indeholder to aktive stoffer: fluticasonfuroat og vilanterol.
English: The primary endpoint was all-cause mortality and a secondary endpoint was a composite of cardiovascular events (on-treatment cardiovascular death, myocardial infarction, stroke, unstable angina, or transient ischemic attack).
Danish: Et sekundært endepunkt var en sammensætning af kardiovaskulære hændelser (kardiovaskulære dødsfald under behandling, myokardieinfarkt, slagtilfælde, ustabil angina, eller forbigående iskæmisk anfald).
English: Asthma Relvar Ellipta is indicated for the regular treatment of asthma in adults and adolescents aged 12 years and older where use of a combination medicinal product (long-acting beta2-agonist and inhaled corticosteroid) is appropriate:
Danish: Astma Relvar Ellipta er indiceret til behandling af astma hos voksne og unge på 12 år og derover, hvor behandling med et kombinationspræparat (langtidsvirkende beta2-agonist og inhalationssteroid) er hensigtsmæssig:
English: Do not open until ready to inhale.
Danish: Åbn ikke, før du er klar til inhalation.
English: Vilanterol trifenatate is a selective long-acting, beta2-adrenergic agonist (LABA).
Danish: Vilanteroltrifenatat er en selektiv, langtidsvirkende beta2-adrenerg agonist (LABA).
English: The 92/22 micrograms strength is used for the regular treatment of chronic obstructive pulmonary disease (COPD) in adults, and asthma in adults and adolescents 12 years and over.
Danish: Styrken på 92/22 mikrogram anvendes til behandling af kronisk obstruktiv lungesygdom (KOL) hos voksne, og til behandling af astma hos voksne og unge fra 12 år og derover.
English: There was no decrease in the extent of in vitro plasma protein binding in subjects with renal or hepatic impairment.
Danish: Der var ingen reduktion i plasmaproteinbindingen in vitro hos patienter med nedsat nyre- eller leverfunktion.
English: Put the mouthpiece between your lips and close your lips firmly around it.
Danish: Placér mundstykket mellem læberne og luk læberne godt sammen omkring mundstykket.
English: 3-4 seconds).
Danish: 4.4 og 4.8).
English: The absolute bioavailability for fluticasone furoate and vilanterol when administered by inhalation as fluticasone furoate/vilanterol was on average 15.2% and 27.3%, respectively.
Danish: Den absolutte biotilgængelighed for fluticasonfuroat og vilanterol, administreret i kombination som inhalation, var i gennemsnit henholdsvis 15,2 % og 27,3 %.
English: Relvar Ellipta 184/22 micrograms is not indicated for patients with COPD.
Danish: Relvar Ellipta 184/22 mikrogram er ikke indiceret til patienter med KOL.
English: If you open and close the cover without inhaling the medicine, you will lose the dose.
Danish: Hvis du åbner og lukker beskyttelseshætten, uden at medicinen inhaleres, vil dosis gå tabt.
English: What you need to know before you use Relvar Ellipta 3.
Danish: Det skal du vide, før du begynder at tage Relvar Ellipta 3.
English: Close the inhaler and rinse your mouth Slide the cover upwards as far as it will go to cover the mouthpiece.
Danish: Luk inhalatoren og skyl munden • Skub beskyttelseshætten så langt tilbage som muligt, så den dækker for mundstykket.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Relvar Ellipta in one or more subsets of the paediatric population in asthma (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har udsat forpligtelsen til at fremlægge resultaterne af studier med Relvar Ellipta i en eller flere undergrupper af den pædiatriske population med astma (se pkt.
English: Chronic Obstructive Pulmonary Disease
Danish: Kronisk obstruktiv lungesygdom
English: Data from large asthma and COPD clinical trials were used to determine the frequency of adverse reactions associated with fluticasone furoate/vilanterol.
Danish: Data fra store kliniske studier med astma og KOL danner baggrund for at fastlægge hyppigheden af bivirkninger forbundet med fluticasonfuroat/vilanterol.
English: The 184/22 micrograms strength is not approved for the treatment of COPD.
Danish: Styrken på 184/22 mikrogram er ikke godkendt til behandling af KOL.
English: PHARMACEUTICAL FORM Inhalation powder, pre-dispensed (Inhalation powder).
Danish: LÆGEMIDDELFORM Inhalationspulver, afdelt (Inhalationspulver)
English: Exposure-adjusted all-cause mortality per 100 patients/year (%/yr) was: fluticasone furoate/vilanterol, 3.1 %/yr; placebo, 3.5 %/yr; fluticasone furoate, 3.2 %/yr; and vilanterol, 3.4 %/yr.
Danish: Forekomst justeret for eksponering for total mortalitet pr. 100 patienter/år (%/år) var: fluticasonfuroat/vilanterol, 3,1 %/år; placebo, 3,5 %/år; fluticasonfuroat, 3,2 %/år; og vilanterol, 3,4 %/år.
English: How to inhale the medicine
Danish: Sådan inhalerer du medicinen
English: The maximum recommended dose is Relvar Ellipta 184/22 micrograms once daily.
Danish: Den anbefalede maksimale dosis er Relvar Ellipta 184/22 mikrogram én gang dagligt.
English: It should not be used to relieve a sudden attack of breathlessness or wheezing.
Danish: Det kan ikke anvendes til lindring ved pludselige anfald af åndenød eller hvæsende vejrtrækning.
English: The bronchoprotective effect of fluticasone furoate/vilanterol 92/22 micrograms on the early and late asthmatic response to inhaled allergen was evaluated in a repeat dose, placebo-controlled four-way crossover study (HZA113126) in patients with mild asthma.
Danish: Den bronkoprotektive effekt af fluticasonfuroat/vilanterol 92/22 mikrogram på tidligt og sent astmatisk respons på inhaleret allergen blev undersøgt hos patienter med let astma i et placebokontrolleret, fire gange overkrydsningsstudie med gentagen dosering (HZA113126).
English: Upper respiratory tract infection Bronchitis
Danish: Infektion i øvre luftveje Bronkitis
English: There was no effect of race on pharmacokinetic parameter estimates of vilanterol in subjects with COPD.
Danish: Race havde ingen indvirkning på estimaterne af de farmakokinetiske parametre for vilanterol hos KOL-patienter.
English: Following intravenous dosing, both fluticasone furoate and vilanterol are extensively distributed with average volumes of distribution at steady state of 661 L and 165 L, respectively.
Danish: Efter intravenøs administration fordeles både fluticasonfuroat og vilanterol i stor udstrækning med et gennemsnitligt distributionsvolumen ved steady state på henholdsvis 661 l og 165 l. Både fluticasonfuroat og vilanterol har lav binding til de røde blodlegemer.
English: If the dose counter does not count down as you hear the ‘click', the inhaler will not deliver medicine.
Danish: Hvis dosistælleren ikke tæller nedad, når du hører 'klikket', vil inhalatoren ikke afgive medicin.
English: The higher strength of Relvar Ellipta (184 micrograms fluticasone furoate and 22 micrograms of vilanterol) is not suitable for the treatment of COPD.
Danish: Den høje styrke af Relvar Ellipta (184 mikrogram fluticasonfuroat og 22 mikrogram vilanterol) er ikke egnet til behandling af KOL.
English: If your breathing or wheezing gets worse straight after using this medicine, stop using it and get medical help immediately.
Danish: Hvis din vejrtrækning eller hvæsen bliver værre umiddelbart efter, at du har taget dette lægemiddel, skal du stoppe med at tage medicinen og søge lægehjælp med det samme.
English: Both fluticasone furoate/vilanterol 92/22 micrograms and FF 92 micrograms virtually abolished the late asthmatic response compared with vilanterol alone.
Danish: Både fluticasonfuroat/vilanterol 92/22 mikrogram og FF 92 mikrogram ophævede stort set det sene astmatiske respons sammenlignet med vilanterol alene.
English: A clinical pharmacology study in healthy subjects with co-administered vilanterol and the potent P-gp and moderate CYP3A4 inhibitor verapamil did not show any significant effect on the pharmacokinetics of vilanterol.
Danish: I et klinisk farmakologisk studie med raske personer, der fik samtidig administration af vilanterol og verapamil, der er en potent P-gphæmmer og en moderat CYP3A4-hæmmer, blev der ikke set nogen signifikant effekt på farmakokinetikken af vilanterol.
English: Pharmacological and toxicological effects seen with fluticasone furoate or vilanterol in nonclinical studies were those typically associated with either glucocorticoids or beta2-agonists.
Danish: De farmakologiske og toksikologiske effekter, der blev set med fluticasonfuroat eller vilanterol i prækliniske studier, var typisk de samme, som normalt ses med henholdsvis glukokortikoider og beta2-agonister.
English: COPD (Chronic Obstructive Pulmonary Disease)
Danish: KOL (kronisk obstruktiv lungesygdom)
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS DEVICE LABEL
Danish: MINDSTEKRAV TIL MÆRKNING PÅ SMÅ INDRE EMBALLAGER ETIKET TIL INHALATOR
English: How to use Relvar Ellipta 4.
Danish: Sådan skal du tage Relvar Ellipta 4.
English: Prescribers should be aware that in patients with asthma, fluticasone furoate (FF) 100 micrograms once daily is approximately equivalent to fluticasone propionate (FP) 250 micrograms twice daily, while FF 200 micrograms once daily is approximately equivalent to FP 500 micrograms twice daily.
Danish: Lægen skal være opmærksom på, at 100 mikrogram fluticasonfuroat (FF) én gang dagligt omtrent er ækvivalent med 250 mg fluticasonpropionat (FP) to gange dagligt, mens 200 mikrogram FF én gang dagligt omtrent er ækvivalent med 500 mikrogram FP to gange dagligt, hos patienter med astma.
English: Relvar Ellipta should not be used to relieve a sudden attack of breathlessness or wheezing.
Danish: Relvar Ellipta kan ikke anvendes til lindring af pludselige anfald af åndenød eller hvæsende vejrtrækning.
English: It will only be effective as long as you are using it. Do not stop unless your doctor advises you to, even if you feel better.
Danish: Medicinen virker kun, så længe du tager den. Du må ikke stoppe behandlingen, medmindre lægen siger det.
English: The safety and efficacy of Relvar Ellipta in children under 12 years of age has not yet been established in the indication for asthma.
Danish: Sikkerhed og virkning af Relvar Ellipta hos børn med astma under 12 år er endnu ikke klarlagt.
English: Following repeat dosing of fluticasone furoate/vilanterol for 7 days, there was no significant increase in systemic exposure to vilanterol (Cmax and AUC) in subjects with mild, moderate, or severe hepatic impairment (Child-Pugh A, B or C).
Danish: Efter gentagen dosering af fluticasonfuroat/vilanterol i 7 dage var der ingen signifikant stigning i den systemiske eksponering af vilanterol (Cmax og AUC) hos patienter med let, moderat eller svær leverinsufficiens (Child-Pugh A, B eller C).
English: Weighted Mean Serial FEV1 over 0-24 hours post-dose Treatment difference
Danish: Vægtet gennemsnitligt seriemåling af FEV1 i de første 24 timer efter dosering Behandlingsforskel
English: If you have severe asthma, your doctor may decide that you should use one inhalation of the higher strength inhaler (184 micrograms fluticasone furoate and 22 micrograms of vilanterol).
Danish: Hvis du har alvorlig astma, kan lægen ordinere en inhalation med den høje styrke (184 mikrogram fluticasonfuroat og 22 mikrogram vilanterol).
English: Asthma-related adverse events and exacerbations may occur during treatment with fluticasone furoate/vilanterol.
Danish: Astmarelaterede bivirkninger og eksacerbationer kan indtræde under behandling med fluticasonfuroat/vilanterol.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Relvar Ellipta in all subsets of the paediatric population in COPD (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med Relvar Ellipta i alle undergrupper af den pædiatriske population ved indikationen KOL (se pkt.
English: Relvar Ellipta is indicated for the symptomatic treatment of adults with COPD with a FEV1<70% predicted normal (post-bronchodilator) with an exacerbation history despite regular bronchodilator therapy.
Danish: Relvar Ellipta er indiceret til symptomatisk behandling af voksne med KOL med FEV1< 70 % af forventet (post-bronkodilatator) med tilbagevendende eksacerbationer, hvor fast behandling med bronkodilatator ikke er tilstrækkelig.
English: Based on in vitro data, the major routes of metabolism of both fluticasone furoate and vilanterol in human are mediated primarily by CYP3A4.
Danish: Baseret på in vitro-data metaboliseres både fluticasonfuroat og vilanterol primært via CYP3A4 hos mennesker.
English: Prepare a dose Wait to open the cover until you are ready to take your dose.
Danish: Vent med at åbne beskyttelseshætten, til du er klar til at tage din dosis.
English: The 24-hour bronchodilator effect of fluticasone furoate/vilanterol was maintained from the first dose throughout a one-year treatment period with no evidence of loss in efficacy (no tachyphylaxis).
Danish: Den 24 timers bronkodilaterende effekt af fluticasonfuroat/vilanterol blev opretholdt fra første dosis og igennem hele behandlingsperioden på et år uden tegn på nedsat effekt (ingen takyfylaksi).
English: The effects of age on the pharmacokinetics of fluticasone furoate and vilanterol were determined in phase III studies in COPD and asthma.
Danish: Alderens indvirkning på farmakokinetikken af fluticasonfuroat og vilanterol er blevet undersøgt i fase IIIstudier med KOL-og astma patienter.
English: Cardioselective beta-blocking medicinal products should be used with caution in patients with a history of bronchospasm.
Danish: Kardioselektive betablokkere skal anvendes med forsigtighed hos patienter med bronkospasme i anamnesen.
English: Visual disturbance may be reported with systemic and topical corticosteroid use.
Danish: Ved brug af systemisk og topikal kortikosteroid kan der blive indberettet sysnforstyrrelser.
English: Symptoms include shortness of breath, cough, chest discomfort and coughing up mucus.
Danish: Symptomerne omfatter åndenød, hoste, ubehag i brystet og ophostning af slim.
English: Subjects randomised to once-daily FF/VI maintained lung function comparable with those randomised to twice-daily salmeterol/FP [difference in trough FEV1 of +19 mL (95% CI: -11, 49)].
Danish: Patienter randomiseret til FF/VI givet en gang daglig vedligeholdte lungefunktion, sammenlignelig med patienter randomiseret til salmeterol/FP givet to gange daglig [forskel i trough-FEV1-værdien på +19 ml (95 % konfidensinterval -11;49)].
English: FF/VI 184/22 Once Daily vs FP 500 Twice Daily
Danish: FF/VI 184/22 en gang daglig versus FP 500 to gange daglig
English: The rate of severe asthma exacerbations per patient per year was 0.19 in the FF 92 micrograms group (approximately 1 in every 5 years) and 0.14 in the fluticasone furoate/vilanterol 92/22 micrograms group (approximately 1 in every 7 years).
Danish: Forekomsten af svære astma-eksacerbationer pr. patient pr. år var 0,19 i FF 92 mikrogram-gruppen (ca. 1 hvert 5. år) og 0,14 i gruppen med fluticasonfuroat/vilanterol 92/22 mikrogram (ca. 1 hvert 7. år).
English: Relvar Ellipta should be discontinued immediately, the patient assessed and alternative therapy instituted if necessary.
Danish: Relvar Ellipta bør omgående seponeres og patienten vurderes.
English: A repeat dose CYP3A4 drug interaction study was performed in healthy subjects with the fluticasone furoate/vilanterol combination (184/22 micrograms) and the strong CYP3A4 inhibitor ketoconazole (400mg).
Danish: Der er udført et CYP3A4-interaktionsstudie med gentagen dosering hos raske voksne af kombinationen fluticasonfuroat/vilanterol (184/22 mikrogram) og den potente CYP3A4hæmmer ketoconazol (400 mg).
English: FF/VI 184/22 Once Daily vs FF 184 Once Daily
Danish: FF/VI 184/22 en gang daglig versus FF 184 en gang daglig
English: Fluticasone furoate/vilanterol 92/22 micrograms provided significantly greater protection against allergen-induced bronchial hyper-reactivity compared with monotherapies FF and vilanterol as assessed on Day 22 by methacholine challenge.
Danish: Fluticasonfuroat/vilanterol 92/22 mikrogram medførte signifikant større beskyttelse mod allergeninduceret bronkial hyperreaktivitet sammenlignet med monoterapi med FF og vilanterol, målt ved metacholintest på dag 22.
English: Co-administration increased mean vilanterol AUC(0-t) and Cmax 65% and 22%, respectively.
Danish: Samtidig administration øgede det gennemsnitlige AUC(0-t) og Cmax af vilanterol med henholdsvis 65 % og 22 %.
English: INFORMATION IN BRAILLE relvar ellipta 92:22
Danish: INFORMATION I BRAILLESKRIFT relvar ellipta 92:22
English: There were no clinically relevant effects of the fluticasone furoate/vilanterol combination on beta-adrenergic systemic effects (heart rate or serum potassium) in subjects with mild or moderate hepatic impairment (vilanterol, 22 micrograms) or with severe hepatic impairment (vilanterol, 12.5 micrograms) compared with healthy subjects.
Danish: Der var ingen klinisk relevant effekt af fluticasonfuroat/vilanterol-kombinationen på beta-adrenerge systemiske måleobjekter (hjertefrekvens eller serumkalium) hos patienter med let eller moderat leverinsufficiens (22 mikrogram vilanterol) eller svær leverinsufficiens (12,5 mikrogram vilanterol) sammenlignet med raske personer.
English: White powder in a light grey inhaler with a yellow mouthpiece cover and a dose counter.
Danish: Hvidt pulver i en lysegrå inhalator med en gul beskyttelseshætte over mundstykket og en dosistæller.
English: Dose-normalised fluticasone furoate systemic exposure was similar in subjects with moderate and severe hepatic impairment (Child-Pugh B or C).
Danish: Den dosis-normaliserede systemiske eksponering af fluticasonfuroat var ens hos patienter med moderat og svær leverinsufficiens (Child-Pugh B eller C).
English: INFORMATION IN BRAILLE relvar ellipta 184:22
Danish: INFORMATION I BRAILLESKRIFT relvar ellipta 184:22
English: FF/VI 92/22 Once Daily vs FF 92 Once Daily
Danish: FF/VI 92/22 en gang daglig versus FF 92 en gang daglig
English: This helps to open the airways and makes it easier for air to get in and out of the lungs.
Danish: Det afslapper musklerne i de små luftveje i lungerne, hvilket er med til at åbne luftvejene og gøre det lettere for luften at komme ind og ud af lungerne.
English: SUMMIT was a multi-centre, randomised, double-blind study evaluating the effect on survival of fluticasone furoate/vilanterol 92/22 micrograms compared with placebo in 16,485 subjects.
Danish: SUMMIT var et multicenter, randomiseret, dobbeltblindet studie med 16.485 personer, der undersøgte effekten af fluticasonfuroat/vilanterol 92/22 mikrogram på overlevelsen sammenlignet med placebo.
English: Patients were randomized to receive fluticasone furoate/vilanterol 92/22 micrograms, FF 92 micrograms, vilanterol 22 micrograms or placebo once daily for 21 days followed by challenge with allergen 1 hour after the final dose.
Danish: Patienterne blev randomiseret til at få fluticasonfuroat/vilanterol 92/22 mikrogram, FF 92 mikrogram, vilanterol 22 mikrogram eller placebo en gang daglig i 21 dage efterfulgt af allergeneksponering 1 time efter den sidste dosis.