FrancophonIA/ELRC3.0 huggingface dataset:
English: Letrozole showed a low degree of acute toxicity in rodents exposed up to 2000 mg/kg.
Slovenian: Letrozol je pokazal nizko stopnjo akutne toksičnosti pri glodalcih, izpostavljenih odmerkom do največ 2000 mg/kg.
English: If you take more {Invented Name} than you should If you have taken too much {Invented Name}, or if someone else accidentally takes your tablets, contact a doctor or hospital for advice immediately.
Slovenian: Če ste vzeli večji odmerek zdravila {Izmišljeno ime}, kot bi smeli Če ste vzeli preveč zdravila {Izmišljeno ime} ali je kdo drug pomotoma vzel vaše tablete, se takoj posvetujete s svojim zdravnikom ali pokličite v bolnišnico.
English: {Invented Name} contains lactose {Invented Name} contains lactose (milk sugar).
Slovenian: Zdravilo {Izmišljeno ime} vsebuje laktozo (mlečni sladkor).
English: Age had no effect on the pharmacokinetics of letrozole.
Slovenian: Starost ni vplivala na farmakokinetiko letrozola.
English: It is not known whether this was an indirect consequence of the pharmacological properties (inhibition of oestrogen biosynthesis) or a direct drug effect (see sections 4.3 and 4.6).
Slovenian: Ni jasno, ali gre za posreden vpliv farmakoloških lastnosti zdravila (zaviranja biosinteze estrogenov) ali za neposredno delovanje zdravila (glejte poglavji 4.3 in 4.6).
English: 3 Observations in the tamoxifen arm censored at the date of selectively switching to letrozole
Slovenian: 3 podatki v skupini s tamoksifenom so cenzurirani na dan selektivnega prehoda na letrozol
English: After administration of 2.5 mg 14C-labelled letrozole, approximately 82% of the radioactivity in plasma was unchanged compound.
Slovenian: Po dajanju 2,5 mg letrozola, označenega s 14C, je približno 82 % radioaktivnosti v plazmi pripadalo nespremenjeni spojini.
English: Median duration of treatment was 5 years for {Invented Name}, compared with 3 years for placebo.
Slovenian: Mediana vrednost trajanja zdravljenja je bila pri zdravilu {Izmišljeno ime} 5 let v primerjavi s 3 leti pri placebu.
English: No dose adjustment is required for elderly patients.
Slovenian: Pri starejših bolnicah ni potrebno prilagajanje odmerka.
English: Cimetidine, a weak, unspecific inhibitor of CYP450 enzymes, did not affect the plasma concentrations of letrozole.
Slovenian: Cimetidin, ki je šibek in nespecifičen zaviralec encima CYP450, ni vplival na koncentracijo letrozola v plazmi.
English: Since steady-state levels are maintained over time, it can be concluded that no continuous accumulation of letrozole occurs.
Slovenian: Ker se koncentracije v stanju dinamičnega ravnovesja s časom ohranjajo, je mogoče sklepati, da ne prihaja do stalnega kopičenja letrozola.
English: Do not take {Invented Name} if you are allergic to letrozole or to any of the other ingredients of this medicine (listed in section 6), if you still have periods, i.e. if you have not yet gone through the menopause,
Slovenian: Ne jemljite zdravila {Izmišljeno ime} - če ste alergični na letrozol ali katero koli sestavino tega zdravila (navedeno v poglavju 6); - če imate še vedno menstrualne krvavitve, kar pomeni, da še niste v obdobju po menopavzi, - če ste noseči,
English: The no-adverse-effect level was 0.3 mg/kg in both species.
Slovenian: Koncentracija brez neželenih učinkov je bila pri obeh vrstah 0,3 mg/kg.
English: {Invented Name} has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo {Izmišljeno ime} ima blag vpliv na sposobnost vožnje in upravljanja s stroji.
English: Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Slovenian: Zdravnik se bo morda odločil za merjenje vaše kostne gostote (s čimer je mogoče spremljati stanje osteoporoze) pred in med zdravljenjem, pa tudi po zaključku zdravljenja.
English: If you have any questions about how {Invented Name} works or why this medicine has been prescribed for you, ask your doctor.
Slovenian: Če vas zanima, kako zdravilo {Izmišljeno ime} deluje ali zakaj so vam predpisali to zdravilo, se obrnite na svojega zdravnika.
English: The suppression of oestrogen biosynthesis in peripheral tissues and the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme.
Slovenian: Zaviranje biosinteze estrogenov v perifernih tkivih in v rakastem tkivu samem je torej mogoče doseči s specifičnim zaviranjem encima aromataze.
English: Protocol definition, including second non-breast primary malignancies, after switch / beyond two years
Slovenian: 1 po opredelitvi v protokolu, vključno z drugim primarnim rakom izven področja dojk, po zamenjavi zdravila / po več kot 2 letih
English: The minor effect on the absorption rate is not considered to be of clinical relevance, and therefore letrozole may be taken without regard to mealtimes.
Slovenian: Manjši vpliv na hitrost absorpcije verjetno nima kliničnega pomena, zato lahko bolnice jemljejo letrozol ne glede na čas obrokov.
English: Study D2407 is an open-label, randomised, multicentre post approval safety study designed to compare the effects of adjuvant treatment with letrozole and tamoxifen on bone mineral density (BMD) and serum lipid profiles.
Slovenian: Študija D2407 je odprta, randomizirana, multicentrična študija varnosti zdravila po njegovi odobritvi, namenjena primerjavi vpliva adjuvantnega zdravljenja z letrozolom in tamoksifenom na mineralno gostoto kosti in na profil lipidov v serumu.
English: As there are reports of women regaining ovarian function during treatment with {Invented Name} despite a clear postmenopausal status at start of therapy, the physician needs to discuss adequate contraception when necessary.
Slovenian: Obstajajo poročila o ženskah, pri katerih se je v času zdravljenja z zdravilom {Izmišljeno ime} ponovno vzpostavilo delovanje jajčnikov kljub jasnemu postmenopavznemu statusu na začetku zdravljenja, zato se mora zdravnik z bolnico pogovoriti o ustrezni kontracepciji, kadar je to potrebno.
English: It inhibits the aromatase enzyme by competitively binding to the haem of the aromatase cytochrome P450, resulting in a reduction of oestrogen biosynthesis in all tissues where present.
Slovenian: Aromatazo zavira tako, da se kompetitivno veže na hem encimske podenote citokroma P450, kar ima za posledico zmanjšanje biosinteze estrogenov v vseh tkivih, v katerih sicer poteka.
English: Food slightly decreases the rate of absorption (median tmax 1 hour fasted versus 2 hours fed; and mean Cmax 129 ± 20.3 nmol/litre fasted versus 98.7 ± 18.6 nmol/litre fed) but the extent of absorption (AUC) is not changed.
Slovenian: Hrana rahlo zmanjša hitrost absorpcije (mediana vrednost tmax na tešče je 1 ura v primerjavi z 2 urama pri zaužitju po obroku; povprečna Cmax na tešče je 129 ± 20,3 nmol/l v primerjavi z 98,7 ± 18,6 nmol/l pri zaužitju po obroku), vendar se obseg absorpcije (AUC) ne spremeni.
English: (95% CI) P
Slovenian: (95 % IZ) P
English: In the neoadjuvant setting, treatment with {Invented Name} could be continued for 4 to 8 months in order to establish optimal tumour reduction.
Slovenian: V okviru neoadjuvantnega zdravljenja je mogoče zdravljenje z zdravilom {Izmišljeno ime} nadaljevati 4 do 8 mesecev, da bi s tem dosegli kar največje zmanjšanje tumorja.
English: In a study involving 19 volunteers with varying degrees of renal function (24-hour creatinine clearance 9116 ml/min) no effect on the pharmacokinetics of letrozole was found after a single dose of 2.5 mg.
Slovenian: V študiji, ki je zajela 19 prostovoljk z različnimi stopnjami delovanja ledvic (24-urni očistek kreatinina 9-116 ml/min), po enkratnem odmerku 2,5 mg niso opažali nobenega vpliva na farmakokinetiko letrozola.
English: Do not take a double dose to make up for the one that you missed.
Slovenian: - Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: Pharmacotherapeutic group: Endocrine therapy.
Slovenian: Farmakoterapevtska skupina: Endokrino zdravljenje.
English: Patients with severe hepatic impairment (Child-Pugh C) require close supervision (see sections 4.4 and 5.2).
Slovenian: Bolnice s hudo okvaro jeter (Child-Pugh razreda C) potrebujejo skrben zdravniški nadzor (glejte poglavji 4.4 in 5.2).
English: HR (95% CI)2
Slovenian: HR (95 % IZ)2
English: {Invented Name} monotherapy
Slovenian: {Izmišljeno ime} monoterapija
English: In patients with severe hepatic impairment (Child-Pugh C), systemic exposure and terminal half-life were approximately doubled compared to healthy volunteers.
Slovenian: Pri bolnicah s hudo okvaro jeter (Child-Pugh razreda C) je bila sistemska izpostavljenost zdravilu približno dvakrat večja, končni razpolovni čas pa je bil približno dvakrat daljši kot pri zdravih prostovoljkah.
English: The most frequently reported adverse reactions in clinical studies were hot flushes, hypercholesterolaemia, arthralgia, fatigue, increased sweating and nausea.
Slovenian: Neželeni učinki, o katerih so v kliničnih študijah najbolj pogosto poročali, so bili vročinski oblivi, hiperholesterolemija, artralgija, utrujenost, povečano znojenje in navzea.
English: The Sequential Treatments Analysis (STA) addresses the second primary question of BIG 1-98, namely whether sequencing of tamoxifen and letrozole would be superior to monotherapy.
Slovenian: Analiza sekvenčnega zdravljenja (sequential treatmens analysis -STA) Analiza sekvenčnega zdravljenja se nanaša na drugo glavno vprašanje v študiji BIG 1-98, in sicer ali je sekvenčno zdravljenje s tamoksifenom in letrozolom boljše od monoterapije.
English: What {Invented Name} is and what it is used for
Slovenian: Kaj je zdravilo {Izmišljeno ime} in za kaj ga uporabljamo
English: Adjusted by chemotherapy use
Slovenian: 2 prilagojeno na uporabo kemoterapije
English: {Invented Name} N=453
Slovenian: {Izmišljeno ime} N=453
English: If you have any further questions, ask your doctor or pharmacist.
Slovenian: - Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom ali farmacevtom.
English: • Advanced breast cancer after relapse or disease progression, in women with natural or artificially induced postmenopausal endocrine status, who have previously been treated with anti-oestrogens.
Slovenian: • Napredovali rak dojke po recidivu ali napredovanju bolezni pri ženskah z naravnim ali umetno povzročenim postmenopavznim endokrinim statusom, ki so se prej zdravile z antiestrogeni.
English: These side effects may affect more than 10 in every 100 patients.
Slovenian: Lahko se pojavijo pri več kot 10 na vsakih 100 bolnikov.
English: In 907 women, letrozole was superior to tamoxifen in time to progression (primary endpoint) and in overall objective response, time to treatment failure and clinical benefit.
Slovenian: Pri 907 ženskah je bil letrozol boljši od tamoksifena glede časa do napredovanja (kar je bil primarni cilj opazovanja) in celotnega objektivnega odziva, časa do prenehanja učinkovitosti zdravljenja in kliničnih koristi.
English: Pruritus, urticaria
Slovenian: dispneja, kašelj
English: Such patients should therefore be kept under close supervision (see section 5.2).
Slovenian: Pri takšnih bolnicah je zato potreben skrben zdravniški nadzor (glejte poglavje 5.2).
English: There is no clinical experience to date on the use of {Invented Name} in combination with oestrogens or other anticancer agents, other than tamoxifen.
Slovenian: Doslej nimamo kliničnih izkušenj z uporabo zdravila {Izmišljeno ime} v kombinaciji z estrogeni ali z drugimi zdravili proti raku, razen s tamoksifenom.
English: The final analysis included 1,551 women who switched from placebo to {Invented Name} at a median of 31 months (range 12 to 106 months) after completion of tamoxifen adjuvant therapy.
Slovenian: V končno analizo je bilo vključenih 1.551 žensk, ki so z uporabe placeba prešle na uporabo zdravila {Izmišljeno ime} po mediano 31 mesecih (od 12 do 106 mesecev) od zaključenega adjuvantnega zdravljenja s tamoksifenom.
English: In postmenopausal women, oestrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens - primarily androstenedione and testosterone - to oestrone and oestradiol.
Slovenian: Pri ženskah v pomenopavzi nastajajo estrogeni predvsem z delovanjem encima aromataze, ki pretvori androgene hormone iz nadledvične žleze, predvsem androstendion in testosteron, v estron in estradiol.
English: Male breast cancer Use of {Invented Name} in men with breast cancer has not been studied.
Slovenian: Rak dojke pri moških Uporabe zdravila {Izmišljeno ime} pri moških z rakom dojke niso proučevali.
English: In female rats, a reduced incidence of benign and malignant mammary tumours at all the doses of letrozole was found.
Slovenian: Pri podganjih samicah so ugotovili zmanjšano pogostnost benignih in malignih tumorjev dojke pri vseh odmerkih letrozola.
English: These side effects may affect between 1 to 10 in every 1,000 patients.
Slovenian: Lahko se pojavijo pri 1 do 10 na vsakih 1.000 bolnikov.
English: It is unknown whether letrozole and its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se letrozol in njegovi presnovki izločajo v materino mleko.
English: The absence of an advantage for {Invented Name} on overall survival could be explained by the crossover design of the study.
Slovenian: Dejstvo, da uporaba zdravila {Izmišljeno ime} ni pomenila prednosti za celokupno preživetje, je mogoče razložiti z navzkrižno zasnovo študije.
English: The first planned interim analysis at a median follow-up of around 28 months (25% of patients being followed up for at least 38 months), showed that {Invented Name} significantly reduced the risk of breast cancer recurrence by 42% compared with placebo (HR 0.58; 95% CI 0.45, 0.76; P=0.00003).
Slovenian: Prva načrtovana vmesna analiza po medianem trajanju spremljanja približno 28 mesecev (25 % bolnic so spremljali najmanj 38 mesecev) je pokazala, da je zdravilo {Izmišljeno ime} v primerjavi s placebom značilno zmanjšalo tveganje recidiva raka dojke za 42 % (razmerje ogroženosti 0,58; 95odstotni IZ 0,45, 0,76 P=0,00003).
English: Angioedema, toxic epidermal necrolysis, erythema multiforme Musculoskeletal and connective tissue disorders Very common:
Slovenian: angioedem, toksična epidermalna nekroliza, multiformni eritem Bolezni mišično-skeletnega sistema in vezivnega tkiva zelo pogosti:
English: Hazard ratio2 (97.5% confidence interval)
Slovenian: N število dogodkov1 razmerje ogroženosti2 (97,5 % interval zaupanja)
English: If any of the above occurs, tell your doctor straight away.
Slovenian: Če se vam zgodi kaj od zgoraj navedenega, takoj sporočite svojemu zdravniku.
English: {Invented Name} is contraindicated during pregnancy (see sections 4.3 and 5.3).
Slovenian: Zdravilo {Izmišljeno ime}je kontraindicirano med nosečnostjo (glejte poglavji 4.3 in 5.3).
English: Table 9 Results at a median follow-up of 32 months
Slovenian: Preglednica 9 Rezultati po medianem trajanju spremljanja 32 mesecev spremenljivka statistična mera
English: As the tablets contain lactose, {Invented Name} is not recommended for patients with rare hereditary problems of galactose intolerance, of severe lactase deficiency or of glucose-galactose malabsorption.
Slovenian: Tablete zdravila {Izmišljeno ime} vsebujejo laktozo, zato njihova uporaba ni priporočena za bolnike z redko dedno intoleranco za galaktozo, s hudo obliko zmanjšane aktivnosti laktaze ali z malabsorpcijo glukoze/galaktoze.
English: Letrozole is highly specific in inhibiting aromatase activity.
Slovenian: Letrozol zelo specifično zavira aktivnost aromataze.
English: [Letrozole →]Tamoxifen 1460
Slovenian: [letrozol →] tamoskifen 1.460 letrozol
English: labelled letrozole to healthy postmenopausal volunteers, 88.2 ± 7.6% of the radioactivity was recovered in urine and 3.8 ± 0.9% in faeces.
Slovenian: zdravim prostovoljkam v pomenopavzi so 88,2 ± 7,6 % radioaktivnosti prestregli iz urina, 3,8± 0,9 % pa iz blata.
English: In the updated quality of life substudy there were no significant differences between treatments in physical component summary score or mental component summary score, or in any domain score in the SF-36 scale.
Slovenian: V dopolnjeni podštudiji kakovosti življenja ni prišlo do nobene značilne razlike med obema načinoma zdravljenja niti pri skupni oceni telesne komponente niti pri skupni oceni duševne komponente ali pri kateri od ocen po področjih na lestvici SF-36.
English: At baseline all patients had tumours stage T2-T4c, N0-2, M0, ER and/or PgR positive and none of the patients would have qualified for breast-conserving surgery.
Slovenian: Ob izhodišču so imele vse bolnice tumorski stadij T2-T4c, N0-2, M0, in ER in/ali PgR pozitiven receptorski status, nobena od bolnic pa ni bila primerna za konzervirajoče kirurško zdravljenje dojke.
English: Hazard ratio (HR) (95% CI for HR) P
Slovenian: razmerje ogroženosti (HR) (95 % IZ za HR) P
English: In premenopausal women, the inhibition of oestrogen synthesis leads to feedback increases in gonadotropin (LH, FSH) levels.
Slovenian: Pri ženskah pred menopavzo zaviranje sinteze estrogenov povzroči povratno zvišanje koncentracije gonadotropinov (LH, FSH).
English: Since fatigue and dizziness have been observed with the use of {Invented Name} and somnolence has been reported uncommonly, caution is advised when driving or using machines.
Slovenian: Ker so pri uporabi zdravila {Izmišljeno ime} opažali utrujenost in omotičnost, občasno pa so poročali tudi o somnolenci, je pri vožnji in upravljanju s stroji priporočena previdnost.
English: In rats that had live foetuses, there was an increase in the incidence of foetal malformations including domed head and cervical/centrum vertebral fusion.
Slovenian: Pri podganah, ki so nosile živ plod, je prišlo do povečane pogostnosti malformacij ploda, vključno s kupolasto obliko glave in zraščenim vratnim/osrednjim delom vretenc.
English: Time to progression was significantly longer, and response rate significantly higher for letrozole irrespective of whether adjuvant anti-oestrogen therapy had been given or not.
Slovenian: V skupini z letrozolom je bil čas do napredovanja značilno daljši, delež bolnic z odzivom pa značilno večji ne glede na to, ali je bolnica prejemala adjuvantno antiestrogensko zdravljenje ali ne.
English: Palpitations1, tachycardia, ischaemic cardiac events(including new or worsening angina, angina requiring surgery, myocardial infarction and myocardial ischaemia)
Slovenian: palpitacije1, tahikardija, ishemični srčni dogodki (vključno z razvojem nove ali s poslabšanjem obstoječe angine pektoris, z angino pektoris, pri kateri je potreben kirurški poseg, z miokardnim infarktom in z ishemijo miokarda)
English: How to store {Invented Name} Contents of the pack and other information
Slovenian: Shranjevanje zdravila {Izmišljeno ime} Vsebina pakiranja in dodatne informacije
English: Women with a history of osteoporosis and/or fractures, or who are at increased risk of osteoporosis, should have their bone mineral density formally assessed prior to the commencement of adjuvant and extended adjuvant treatment and monitored during and following treatment with letrozole.
Slovenian: Ženskam z anamnezo osteoporoze in/ali zlomov kosti ali s povečanim tveganjem za osteoporozo je treba pred začetkom adjuvantnega ali podaljšanega adjuvantnega zdravljenja formalno izmeriti mineralno gostoto kosti in jo nato spremljati v času jemanja letrozola in po zaključku zdravljenja z njim.
English: Increased FSH levels in turn stimulate follicular growth, and can induce ovulation.
Slovenian: Zvišana koncentracija FSH pa nato spet stimulira rast foliklov in lahko sproži ovulacijo.
English: Both in vitro and in vivo investigations of letrozole's mutagenic potential revealed no indications of any genotoxicity.
Slovenian: Raziskave mutagenega potenciala letrozola tako in vitro kot in vivo niso razkrile nikakršnih znakov genotoksičnosti.
English: In a multicentre, double-blind, randomised, placebo-controlled study (MA-17), over 5,100 postmenopausal women with receptor-positive or unknown primary breast cancer who had completed adjuvant treatment with tamoxifen (4.5 to 6 years) were randomised to either {Invented Name} or placebo for 5 years.
Slovenian: V multicentrični, dvojno slepi, randomizirani, s placebom kontrolirani študiji (MA-17) so več kot 5.100 bolnic v pomenopavzi s primarnim rakom dojke s pozitivnim ali neznanim receptorskim statusom po zaključenem adjuvantnem zdravljenju s tamoksifenom (4,5 do 6 let) randomizirali bodisi v skupino z zdravilom {Izmišljeno ime} ali v skupino s placebom za 5 let.
English: Overall survival Deaths
Slovenian: Celokupno preživetje umrli umrli4
English: Some adverse reactions have been reported with notably different frequencies in the adjuvant treatment setting.
Slovenian: O nekaterih neželenih učinkih so v okviru adjuvantnega zdravljenja poročali z bistveno drugačno pogostnostjo.
English: Skeletal adverse reactions For skeletal safety data from the adjuvant setting, please refer to Table 2.
Slovenian: Skeletni neželeni učinki Za podatke o varnosti zdravila glede skeleta v okviru adjuvantnega zdravljenja glejte preglednico 2.
English: Most of the side effects are mild to moderate and will generally disappear after a few days to a few weeks of treatment.
Slovenian: Večina neželenih učinkov zdravila {Izmišljeno ime} je blago do zmerno izraženih in večinoma izzvenijo po nekaj dneh do nekaj tednih zdravljenja.
English: Plasma levels of LH and FSH are not affected by letrozole in patients, nor is thyroid function as evaluated by TSH, T4, and T3 uptake test.
Slovenian: Letrozol pri bolnicah ne vpliva niti na ravni LH in FSH v plazmi niti na delovanje ščitnice, ocenjeno z meritvijo vrednosti TSH in T4 ter testom privzema T3.
English: You must not take {Invented Name} if you are pregnant or breast feeding as it may harm your baby.
Slovenian: - Če ste noseči ali dojite, ne smete jemati zdravila {Izmišljeno ime}, saj bi lahko škodilo vašemu otroku.
English: Study design allowed patients to cross over upon progression to the other therapy or discontinue from the study.
Slovenian: Zasnova študije je dovoljevala, da so bolnice po napredovanju bolezni lahko zamenjale zdravilo ali prekinile sodelovanje v študiji.
English: Co-administration of {Invented Name} with tamoxifen, other anti-oestrogens or oestrogen-containing therapies should be avoided as these substances may diminish the pharmacological action of letrozole (see section 4.5).
Slovenian: Sočasni uporabi zdravila {Izmišljeno ime} s tamoksifenom, z drugimi antiestrogeni ali z zdravili, ki vsebujejo estrogen, se je treba izogibati, saj navedena zdravila lahko zmanjšajo farmakološko delovanje letrozola (glejte poglavje 4.5).
English: Letrozole 2.5 mg was statistically superior to aminoglutethimide for time to progression (P=0.008), time to treatment failure (P=0.003) and overall survival (P=0.002).
Slovenian: Letrozol v odmerku 2,5 mg je bil statistično boljši od aminoglutetimida glede časa do napredovanja bolezni (P=0,008), časa do prenehanja učinkovitosti zdravljenja (P=0,003) in celokupnega preživetja (P=0,002).
English: Metabolic clearance to a pharmacologically inactive carbinol metabolite is the major elimination pathway of letrozole (CLm = 2.1 l/h) but is relatively slow when compared to hepatic blood flow (about 90 l/h).
Slovenian: Poglavitna pot odstranjevanja letrozola iz telesa je presnova v farmakološko neaktiven karbinolni presnovek (s presnovnim očistkom Clm = 2,1 l/h), kar poteka razmeroma počasi v primerjavi s pretokom krvi skozi jetra (okrog 90 l/h).
English: {Invented Name} reduces the amount of oestrogen by blocking an enzyme (“aromatase”) involved in the production of oestrogens and therefore may block the growth of breast cancer that needs oestrogens to grow.
Slovenian: Zdravilo {Izmišljeno ime} zmanjšuje količino estrogenov tako, da zavira encim ("aromatazo"), ki sodeluje pri nastajanju estrogenov, s tem pa zavira tudi rast raka dojke, ki za svojo rast potrebuje estrogene.
English: With doses of 0.5 mg and higher, many values of oestrone and oestrone sulphate were below the limit of detection in the assays, indicating that higher oestrogen suppression is achieved with these doses.
Slovenian: Pri odmerkih 0,5 mg ali več so bile vrednosti estrona in estron sulfata pri testiranjih pogosto pod mejo merljivosti, kar kaže, da je s takimi odmerki mogoče doseči močnejšo supresijo estrogenov.