FrancophonIA/ELRC3.0 huggingface dataset:
English: Consider dose escalation up to 20 mg in subsequent cycles based on patient tolerability.
Icelandic: Íhuga að auka skammtinn í 20 mg í síðari meðferðarlotum í samræmi við þol sjúklingsins.
English: - Do not store above 30°C.
Icelandic: - Ef innan við 12 klst.
English: 1.8- and 1.6-fold, respectively, and it cannot be excluded that the effect may be larger on a more sensitive CYP2D6 substrate.
Icelandic: Panobinostat jók Cmax og AUC fyrir dextrometorphan (hvarfefni CYP2D6) 1,8 falt og 1,6 falt, tilgreint í sömu röð, og ekki er hægt að útiloka að áhrifin séu meiri á næmari hvarfefni CYP2D6.
English: ECG
Icelandic: Kaplan
English: Farydak 10 mg hard capsules Gelatin
Icelandic: Farydak 10 mg hörð hylki Gelatína
English: Agents that may increase panobinostat plasma concentrations
Icelandic: Lyf sem panobinostat getur aukið plasmaþéttni hjá
English: Each hard capsule contains panobinostat lactate anhydrous equivalent to 20 mg panobinostat.
Icelandic: Hvert hart hylki inniheldur vatnsfrítt panobinostat laktat sem jafngildir 20 mg af panobinostati.
English: Anti-emetic medicinal products with a known risk of QT prolongation such as dolasetron, granisetron, ondansetron and tropisetron should be used with caution (see section 4.4).
Icelandic: QT bils, svo sem dolasetron, granisetron, ondansetron og tropisetron (sjá kafla 4.4).
English: Agents whose plasma exposure can be decreased by panobinostat
Icelandic: Lyf sem panobinostat getur dregið úr útsetningu fyrir í plasma
English: Grade 3
Icelandic: Vika 3
English: An updated RMP should be submitted:
Icelandic: QT bils gilda eftirfarandi ráðleggingar:
English: Table 8 Progression-free survival in patients who received at least two prior regimens including bortezomib and an immunomodulating agent
Icelandic: Tafla 8 Lifun án sjúkdómsversnunar hjá sjúklingum sem höfðu áður fengið að minnsta kosti tvær meðferðir sem fólu í sér bortezomib og ónæmistemprandi lyf
English: Gastrointestinal haemorrhage, haematochezia, gastritis, cheilitis, abdominal distension, dry mouth, flatulence
Icelandic: Blæðing í meltingarfærum, ferskt blóð í hægðum (haematochezia), magabólga, varabólga, þaninn kviður, munnþurrkur, vindgangur
English: The volume of distribution of panobinostat at steady state (Vss) is approximately 1,000 litres based on final parameter estimates in the population pharmacokinetic analysis.
Icelandic: Dreifingarrúmmál panobinostats við jafnvægi (Vss) er um það bil 1.000 lítrar samkvæmt mati á lokabreytum í lyfjahvarfagreiningu hjá þýði.
English: Hepatic function abnormal, hyperbilirubinaemia a
Icelandic: Óeðlileg lifrarstarfsemi, gallrauðadreyri a
English: Psychiatric disorders
Icelandic: Depilblæðingar
English: Farydak 20 mg capsules panobinostat
Icelandic: Farydak 20 mg hylki panobinostat
English: • flatulence
Icelandic: A. ÁLETRANIR
English: Musculoskeletal and connective tissue disorders
Icelandic: ósjálfráðar líkamshreyfingar
English: Septic shock, urinary tract infection, viral infection, oral herpes, Clostridium difficile colitis, otitis media, cellulitis, sepsis, gastroenteritis, lower respiratory tract infection, candidiasis
Icelandic: Sýklasóttarlost, þvagfærasýking, veirusýking, herpessýking í munni, ristilbólga af völdum Clostridium difficile, miðeyrnabólga, húðbeðsbólga, sýklasótt, maga- og garnabólga, sýking í neðri öndunarvegi, hvítsveppasýking
English: QTcF should be <480 msec prior to initiation of treatment with Farydak.
Icelandic: QTcF skal vera <480 msek.
English: Anti-emetic medicinal products with a known risk of QT prolongation such as dolasetron, granisetron, ondansetron and tropisetron should be used with caution (see section 4.5).
Icelandic: QT bils, svo sem dolasetron, granisetron, ondansetron og tropisetron (sjá kafla 4.5).
English: Each hard capsule contains panobinostat lactate anhydrous equivalent to 15 mg panobinostat.
Icelandic: Hvert hart hylki inniheldur vatnsfrítt panobinostat laktat sem jafngildir 15 mg af panobinostati.
English: Gastrointestinal toxicity
Icelandic: LYFJAGERÐARFRÆÐILEGAR UPPLÝSINGAR
English: It is unknown whether panobinostat is excreted in human milk.
Icelandic: Ekki er vitað hvort hægt er að fjarlægja panobinostat með blóðskilun.
English: Bradycardia, atrial fibrillation, sinus tachycardia, tachycardia, palpitation
Icelandic: halofantrin, metadon, moxifloxacin, bepridil eða pimozíð.
English: EU/1/15/1023/002 12 capsules EU/1/15/1023/003 24 capsules
Icelandic: EU/1/15/1023/001 6 hylki EU/1/15/1023/002 12 hylki EU/1/15/1023/003 24 hylki
English: Respiratory failure, rales, wheezing, epistaxis
Icelandic: Hægtaktur, gáttatif, skútahraðtaktur, hraðtaktur, hjartsláttarónot
English: Table 9 Response rates in patients with multiple myeloma who received at least two prior regimens including bortezomib and an immunomodulatory agent
Icelandic: Tafla 9 Svörunarhlutföll hjá sjúklingum með mergæxlager sem fengu áður að minnsta kosti tvær meðferðir, sem fólu í sér bortezomib og ónæmistemprandi lyf
English: Farydak 15 mg capsules panobinostat
Icelandic: Farydak 15 mg hylki panobinostat
English: • The patient compliance card shall contain instructions on the following key messages: o How to become familiar with the compliance card: this section provides a general overview of the compliance card and its purpose.
Icelandic: Meðferðarheldnispjaldið fyrir sjúklinga skal innihalda leiðbeiningar um eftirtalin lykilatriði:
English: Each hard capsule contains panobinostat lactate anhydrous equivalent to 10 mg panobinostat.
Icelandic: Hvert hart hylki inniheldur vatnsfrítt panobinostat laktat sem jafngildir 10 mg af panobinostati.
English: Permanently discontinue
Icelandic: Hætta meðferð endanlega
English: • feeling thirsty, high urine output, increased appetite with weight loss (signs of a high level of sugar in the blood)
Icelandic: • þorsti, mikil þvaglát, aukin matarlyst ásamt þyngdartapi (einkenni blóðsykurshækkunar)
English: Consider dose escalation up to 15 mg in subsequent cycles based on patient tolerability.
Icelandic: Íhuga að auka skammtinn í 15 mg í síðari meðferðarlotum í samræmi við þol sjúklingsins.
English: In clinical studies in multiple myeloma, the exposure of panobinostat was decreased by approximately 20% by the concomitant use of dexamethasone, which is a dose-dependent mild/moderate CYP3A4 inducer.
Icelandic: 20% við samhliða notkun með dexametasoni, sem er skammtaháður, vægur/miðlungsmikill virkir CYP3A4.
English: QTcF should be <480 msec prior to initiation of treatment with panobinostat (see below section on dose adjustments and section 4.4).
Icelandic: áður en meðferð með panobinostati er hafin (sjá kafla hér fyrir neðan um breytingar á skömmtum og kafla 4.4).
English: Bortezomib dose on recovery to grade 2 neutropenia
Icelandic: Skammtur bortezomibs þegar blóðflagnafæðin er aftur orðin af 2. stigi
English: Farydak 10 mg capsules panobinostat
Icelandic: Farydak 10 mg hylki panobinostat
English: If you are pregnant, think you might be pregnant or plan to become pregnant, ask your doctor for advice.
Icelandic: Við meðgöngu, grun um þungun eða ef þungun er fyrirhuguð skal leita ráða hjá lækninum.
English: Table 1 Recommended schedule for taking Farydak in combination with bortezomib and dexamethasone (cycles 1-8)
Icelandic: Farydak ásamt bortezomibi og dexametasoni (meðferðarlotur 1-8)
English: Cardiac disorders
Icelandic: hjartsláttarónot
English: Fatalities involving either pneumonia or sepsis were reported.
Icelandic: Greint var frá dauðsföllum vegna annaðhvort lungnabólgu eða sýklasóttar.
English: How to take Farydak
Icelandic: Hvernig nota á Farydak
English: Farydak 20 mg hard capsules are red opaque capsules (19.1-19.7 mm) containing white to almost white powder, with radial marking “LBH 20 mg” in black ink on the cap and two radial bands in black ink on the body, provided in blisters.
Icelandic: Farydak 20 mg hörð hylki eru rauð, ógegnsæ hylki (19,1-19,7 mm) sem innihalda hvítt eða því sem næst hvítt duft, auðkennd með textanum „LBH 20 mg“ prentuðum með svörtu bleki umhverfis hettuna og tveimur strikum prentuðum með svörtu bleki umhverfis bolinn.
English: Table 2 Recommended schedule for taking Farydak in combination with bortezomib and dexamethasone (cycles 9-16).
Icelandic: Farydak ásamt bortezomibi og dexametasoni (meðferðarlotur 9-16).
English: • increased blood level of the waste product creatinine
Icelandic: • aukið magn úrgangsefnisins kreatíníns í blóði
English: Farydak 20 mg hard capsules
Icelandic: Farydak 20 mg hörð hylki
English: Skin lesions, rash, erythema
Icelandic: Sár á húð, útbrot, roðaþot
English: • cracked, chapped lips
Icelandic: • sprungnar, flagnaðar varir
English: Farydak 10 mg hard capsules
Icelandic: Farydak 10 mg hörð hylki
English: Farydak 15 mg hard capsules
Icelandic: Farydak 15 mg hörð hylki
English: Farydak 15 mg hard capsules are orange opaque capsules (19.1-19.7 mm) containing white to almost white powder, with radial marking “LBH 15 mg” in black ink on the cap and two radial bands in black ink on the body, provided in blisters.
Icelandic: Farydak 15 mg hörð hylki eru appelsínugul, ógegnsæ hylki (19,1-19,7 mm) sem innihalda hvítt eða því sem næst hvítt duft, auðkennd með textanum „LBH 15 mg“ prentuðum með svörtu bleki umhverfis hettuna og tveimur strikum prentuðum með svörtu bleki umhverfis bolinn.
English: • diarrhoea, abdominal pain, fever (signs of an inflamed colon)
Icelandic: • niðurgangur, kviðverkur, hiti (einkenni ristilbólgu)
English: The baseline platelet count should be ≥100 x 109/l and the baseline absolute neutrophil count (ANC) ≥1.0 x 109/l.
Icelandic: Blóðflagnafjöldi í upphafi skal vera ≥100 x 109/l og heildarfjöldi daufkyrninga í upphafi ≥1,0 x 109/l.
English: For patients experiencing severe adverse drug reactions other than thrombocytopenia, gastrointestinal toxicity, neutropenia or QTc prolongation, the recommendation is the following:
Icelandic: Hjá sjúklingum sem fá alvarlegar aukaverkanir aðrar en blóðflagnafæð, eiturverkanir á meltingarfæri, daufkyrningafæð eða lengingu
English: Discontinuation due to adverse events, regardless of causality, was observed in 36.2% of patients.
Icelandic: Hjá 36,2% sjúklinga var meðferð hætt vegna aukaverkana, óháð orsök.
English: • headache
Icelandic: Hjartalínurit
English: Farydak 10 mg hard capsules are light green opaque capsules (15.6-16.2 mm) containing white to almost white powder, with radial marking “LBH 10 mg” in black ink on the cap and two radial bands in black ink on the body, provided in blisters.
Icelandic: Farydak 10 mg hörð hylki eru ljósgræn, ógegnsæ hylki (15,6-16,2 mm) sem innihalda hvítt eða því sem næst hvítt duft, auðkennd með textanum „LBH 10 mg“ prentuðum með svörtu bleki umhverfis hettuna og tveimur strikum prentuðum með svörtu bleki umhverfis bolinn.
English: Table 7 Panobinostat adverse drug reactions observed in multiple myeloma patients in the phase III study
Icelandic: Aukaverkanir panobinostats sem komu fram hjá sjúklingum með mergæxlager í III.
English: Talk to your doctor or pharmacist before taking Farydak: - if you have liver problems or have ever had liver disease.
Icelandic: Leitið ráða hjá lækninum eða lyfjafræðingi áður en Farydak er notað:
English: Mild hypothyroidism was reported in patients treated with panobinostat + bortezomib + dexamethasone in Study D2308; some patients required treatment (see section 4.4).
Icelandic: Greint var frá vægri vanvirkni skjaldkirtils hjá sjúklingum á meðferð með panobinostati + bortezomibi + dexametasoni í rannsókn D2308.
English: Any
Icelandic: Einhver
English: Light green opaque hard gelatin capsule (15.6-16.2 mm) containing white to almost white powder, with radial marking “LBH 10 mg” in black ink on cap and two radial bands in black ink on body.
Icelandic: Ljósgræn, ógegnsæ, hörð gelatínuhylki (15,6-16,2 mm) sem innihalda hvítt eða því sem næst hvítt duft, auðkennd með textanum „LBH 10 mg“ prentuðum með svörtu bleki umhverfis hettuna og tveimur strikum prentuðum með svörtu bleki umhverfis bolinn.
English: Farydak 15 mg hard capsules panobinostat
Icelandic: Farydak 15 mg hörð hylki panobinostat
English: • chills
Icelandic: (BL)
English: Red opaque hard gelatin capsule (19.1-19.7 mm) containing white to almost white powder, with radial marking “LBH 20 mg” in black ink on cap and two radial bands in black ink on body.
Icelandic: Rauð, ógegnsæ, hörð gelatínuhylki (19,1-19,7 mm) sem innihalda hvítt eða því sem næst hvítt duft, auðkennd með textanum „LBH 20 mg“ prentuðum með svörtu bleki umhverfis hettuna og tveimur strikum prentuðum með svörtu bleki umhverfis bolinn.
English: Haemorrhage intracranial, syncope, tremor, dysgeusia
Icelandic: Innankúpublæðingar, yfirlið, skjálfti, bragðskynstruflun
English: Farydak 20 mg hard capsules panobinostat
Icelandic: Farydak 20 mg hörð hylki panobinostat
English: Hyperglycaemia, dehydration, hypoalbuminaemia, fluid retention, hyperuricaemia, hypocalcaemia, hypomagnesaemia
Icelandic: Blóðsykurshækkun, vökvaskortur, albúmínskortur í blóði, vökvasöfnun, þvagsýrublæði, blóðkalsíumskortur, blóðmagnesíumskortur
English: Resume at same dose Omit dose Resume at same dose
Icelandic: Notkun annarra lyfja samhliða Farydak
English: Farydak 10 mg hard capsules panobinostat
Icelandic: Farydak 10 mg hörð hylki panobinostat
English: Kaplan Meier medians PAN+BTZ+Dex: 12.48 months PBO+BTZ+Dex: 4.70 months
Icelandic: 12,48 mánuðir PBO+BTZ+Dex:
English: Farydak metabolism is through both non-CYP and CYP mediated routes.
Icelandic: Umbrot Farydak verða bæði fyrir tilstilli CYP og eftir ferlum sem ekki fela í sér CYP.
English: Orange opaque hard gelatin capsule (19.1-19.7 mm) containing white to almost white powder, with radial marking “LBH 15 mg” in black ink on cap and two radial bands in black ink on body.
Icelandic: Appelsínugul, ógegnsæ, hörð gelatínuhylki (19,1-19,7 mm) sem innihalda hvítt eða því sem næst hvítt duft, auðkennd með textanum „LBH 15 mg“ prentuðum með svörtu bleki umhverfis hettuna og tveimur strikum prentuðum með svörtu bleki umhverfis bolinn.
English: Patients should be monitored for signs and symptoms of infections during treatment with panobinostat; if a diagnosis of infection is made, appropriate anti-infective treatment should be instituted promptly and interruption or discontinuation of Farydak considered.
Icelandic: Ef sýking greinist skal hefja viðeigandi meðferð við sýkingunni sem fyrst og íhuga að gera hlé á eða stöðva meðferðina með Farydak.
English: Very common Pancytopenia, thrombocytopenia, anaemia, leukopenia, neutropenia, lymphopenia
Icelandic: Blóðfrumnafæð, blóðflagnafæð, blóðleysi, hvítkornafæð, daufkyrningafæð, eitilfrumnafæð
English: EU/1/15/1023/007-009
Icelandic: Farydak 20 mg hörð hylki EU/1/15/1023/007-009
English: • weight gain, feeling tired, hair loss, muscle weakness, feeling cold (signs of an underactive thyroid gland, which is known as hypothyroidism)
Icelandic: • þyngdaraukning, þreyta, hárlos, vöðvamáttleysi, kuldatilfinning (einkenni vanvirks skjaldkirtils,
English: Medicinal products with laxative properties should be used with caution because of the potential for exacerbation of diarrhoea.
Icelandic: Gæta skal varúðar við notkun ógleðistillandi lyfja sem vitað er að auka líkur á lengingu
English: Agents that are predicted to decrease panobinostat concentrations
Icelandic: Lyf sem búist er við að dragi úr þéttni panobinostats
English: Panobinostat is rapidly and almost completely absorbed with Tmax reached within 2 hours of oral administration in patients with advanced cancer.
Icelandic: Upptaka panobinostats er hröð og því sem næst algjör þar sem Tmax næst innan 2 klst.
English: Infection
Icelandic: Lyfjagjöf
English: • feeling tired, itching, yellowing of the skin and whites of the eyes, nausea or vomiting, loss of appetite, pain on the right side of your stomach, dark or brown urine, bleeding or bruising more easily than normal (signs of a liver problem)
Icelandic: verkur hægra megin í kvið, dökkt eða brúnt þvag, blæðingar eða mar af minna tilefni en venjulega (einkenni lifrarsjúkdóms)
English: Very common Insomnia
Icelandic: Mjög algengar
English: Electrocardiographic changes
Icelandic: Breytingar á hjartalínuriti
English: Given its cytostatic/cytotoxic mode of action, breast-feeding is contraindicated during Farydak treatment (see section 4.3).
Icelandic: Vegna frumuhemjandi/frumuskemmandi verkunarmáta má ekki vera með barn á brjósti meðan á meðferð með Farydak stendur (sjá kafla 4.3).
English: • abdominal pain, diarrhoea, swelling or bloating of the abdomen (signs of inflamed stomach lining)
Icelandic: • kviðverkur, niðurgangur, þrútinn eða þaninn kviður (einkenni bólgu í magaslímhúð)
English: The efficacy and safety of panobinostat in combination with bortezomib and dexamethasone were evaluated in a randomised, double-blind, placebo-controlled, multicentre phase III study in patients with relapsed or relapsed and refractory multiple myeloma who had received 1-3 prior lines of therapies.
Icelandic: Lagt var mat á verkun og öryggi panobinostats samhliða bortezomibi og dexametasoni í slembaðri, tvíblindri, fjölsetra, III.
English: Grade on day of treatment
Icelandic: Aukaverkun Alvarleikastig á meðferðardegi
English: • clicking, rattling or crackling noise made by the lungs when breathing
Icelandic: • smellir, skrölt eða brak í lungum við öndun
English: - Based on the recommendation of your doctor, the dose of Farydak is either 20 mg or 15 mg or
Icelandic: - Samkvæmt ráðleggingum læknisins er skammturinn af Farydak annaðhvort
English: Cardiac monitoring and assessment of electrolytes and platelet counts should be undertaken and supportive care given as necessary in the event of overdose.
Icelandic: Ef ofskömmtun á sér stað skal framkvæma eftirlit með hjartastarfsemi og mat á blóðsöltum og blóðflagnafjölda og veita stuðningsmeðferð eftir þörfum.
English: - if you notice any signs of a heart problem.
Icelandic: - einhverjum einkennum hjartakvilla.
English: Each pipette delivers:
Icelandic: Hver pípetta gefur:
English: Each cardboard box contains 1 or 2 pipettes.
Icelandic: Hver askja inniheldur 1 eða 2 pípettur.
English: It takes up to 48 hours for the application site to become dry but it will be noticeable for longer.
Icelandic: Það tekur allt að 48 klukkustundir fyrir notkunarstaðinn að verða þurr en hann verður greinilegur lengur.
English: The product is highly flammable.
Icelandic: Dýralyfið er mjög eldfimt.
English: ATCvet code: QP54AB52.
Icelandic: QP54AB52
English: This includes cuddling the animal and sharing a bed with the animal.
Icelandic: Þetta felur í sér að faðma dýrið og deila rúmi með dýrinu.
English: Butylhydroxytoluene Dimethylacetamide Glycofurol
Icelandic: Butylhydorxytoluen Dímetylacetamið Glycofurol
English: Date of first authorisation: 08/05/2018
Icelandic: Dagsetning fyrstu útgáfu markaðsleyfis: 08/05/2018
English: Do not use directly on skin lesions.
Icelandic: Ekki nota beint á húðskemmdir.
English: Newly emerged fleas on a cat are killed before viable eggs are produced.
Icelandic: Nýtilkomnar flær á ketti eru drepnar áður en lífvænleg egg myndast.
English: Where necessary, cats can be re-treated at 12-week intervals.
Icelandic: Þar sem nauðsyn krefur má meðhöndla ketti á 12 vikna fresti.
English: In some cases, soap and water is not sufficient to remove the product spilled on the fingers, therefore gloves must be used.
Icelandic: Í sumum tilfellum er sápa og vatn ekki nægjanlegt til að fjarlægja lyfið sem hellst hefur á fingurna og því verður að nota hanska.
English: Do not allow treated animals to come into contact with untreated animals until the application site is dry.
Icelandic: Ekki skal leyfa meðhöndluðum dýrum að komast í snertingu við ómeðhöndluð dýr þar til meðferðarsvæðið er þurrt.
English: Intervet UK Limited Walton Manor, Walton, Milton Keynes, Buckinghamshire, MK7 7AJ United Kingdom
Icelandic: Intervet UK Limited Walton Manor, Walton, Milton Keynes, Buckinghamshire, MK7 7AJ Bretland
English: Seek further veterinary examination (i.e. otoscopy) 28 days after treatment to determine whether there is re-infestation requiring additional treatment.
Icelandic: Leitið frekari dýralæknisskoðunar (þ.e. eyrnaspeglunar) 28 dögum eftir meðferð til að ákvarða hvort það sé endursýking sem krefst viðbótarmeðferðar.
English: Bravecto Plus spot-on solution is available in three pipette sizes.
Icelandic: Bravecto Plus blettunarlausn er fáanleg í þremur pípettustærðum.
English: The period between treatment and return from the endemic areas should not exceed 60 days.
Icelandic: Tíminn milli meðferðar og heimkomu frá svæði þar sem sjúkdómurinn er landlægur ætti ekki að vera lengri en 60 dagar.
English: Each ml of solution contains 280 mg fluralaner and 14 mg moxidectin.
Icelandic: Hver ml lausnar inniheldur 280 mg fluralaner og 14 mg moxidectin.
English: Intervet Productions Rue de Lyons 27460 Igoville FRANCE
Icelandic: Rue de Lyons 27460 Igoville FRAKKLAND
English: The cap will stay on the pipette; it is not possible to remove it.
Icelandic: Hettan mun haldast á pípettunni, það er ekki hægt að fjarlægja hana.
English: The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
Icelandic: Lyfið má nota sem hluta af meðferðaráætlun til að hafa hemil á ofnæmishúðbólgu vegna flóabits (flea allergy dermatitis (FAD)).
English: Do not allow recently treated animals to groom each other.
Icelandic: Ekki skal leyfa dýrum sem nýlega hafa fengið meðferð að snyrta hvert annað.
English: If skin contact does occur, wash the affected area immediately with soap and water.
Icelandic: Ef snerting við húð á sér stað skal þvo viðkomandi svæðið strax með sápu og vatni.
English: An in vitro study also demonstrated that very low concentrations of fluralaner stop the production of viable eggs by fleas.
Icelandic: In vitro rannsókn sýndi einnig fram á að mjög lág þéttni fluralaner stöðvar myndun lífvænlegra eggja hjá flóm.
English: Keep away from heat, sparks, open flame or other sources of ignition.
Icelandic: Haldið fjarri hita, neistum, opnum eldi eða öðrum uppsprettum íkveikju.
English: The pipette is open and ready for application when the breaking of the seal is felt.
Icelandic: Pípettan er opin og tilbúin til notkunar þegar notandinn finnur innsiglið rofna.
English: Care should be taken to avoid contact with the eyes of the animal.
Icelandic: Gæta skal þess að dýralyfið komist ekki í snertingu við augu dýrsins.
English: Milbemycins and avermectins have a common mode of action that is based on the binding of ligandgated chloride channels (glutamate-R and GABA-R).
Icelandic: Milbemycin og avermectin eru með sameiginlegan verkunarhátt sem byggist á bindingu við efnastýrð klórgöng (glutamat-R og GABA-R).
English: Skin rashes, tingling or numbness have been reported in a small number of individuals after skin contact.
Icelandic: Húðútbrot, náladofi eða dofi hefur verið tilkynntur hjá fáum einstaklingum eftir snertingu við húð.
English: For the prevention of heartworm disease caused by Dirofilaria immitis for 8 weeks.
Icelandic: Fyrirbyggjandi meðferð gegn hjartaormaveiki af völdum Dirofilaria immitis í 8 vikur.
English: The onset of effect (killing effect) for ticks (I. ricinus) and fleas (C. felis) is within 48 hours after treatment.
Icelandic: Verkun (drápsáhrif) eftir meðferð fyrir mítla (I. ricinus) og fyrir flær (C. felis) kemur fram innan 48 klst.
English: Make sure that your animal's application site is no longer noticeable before resuming contact with the site of application.
Icelandic: Gakktu úr skugga um að notkunarstaður dýrsins sé ekki lengur greinilegur áður en þú snertir notkunarstaðinn aftur.
English: Do not use this veterinary medicinal product after the expiry date stated on the packaging after EXP.
Icelandic: Ekki skal nota dýralyfið eftir fyrningardagsetningu sem tilgreind er á umbúðunum á eftir EXP.
English: The use of this veterinary medicinal product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species in order to limit the possibility of a future selection for resistance.
Icelandic: Notkun þessa dýralyfs ætti að byggjast á mati á hverju tilviki og staðbundnum faraldsfræðilegum upplýsingum um núverandi næmi markdýrategundarinnar í því skyni að takmark möguleika á vali á þolmyndun í framtíðinni.