FrancophonIA/ELRC3.0 huggingface dataset:
English: Thyrogen is indicated for use with serum thyroglobulin (Tg) testing with or without radioiodine imaging for the detection of thyroid remnants and well-differentiated thyroid cancer in post-thyroidectomy patients maintained on hormone suppression therapy (THST).
Croatian: Thyrogen je indiciran za primjenu pri određivanju tireoglobulina (Tg) u serumu, sa ili bez radiojodne scintigrafije, radi otkrivanja ostatnog tkiva štitnjače i dobro diferenciranog karcinoma štitnjače nakon provedene tireoidektomije u bolesnika koji dalje primaju supresijsku terapiju tireoidnim hormonom.
English: - The active substance is thyrotropin alfa.
Croatian: Djelatna tvar je tireotropin alfa.
English: When you undergo radioiodine imaging or elimination (ablation), your doctor will give you radioiodine 24 hours after your final Thyrogen injection.
Croatian: Kada morate obaviti pretragu ili uklanjanje tkiva (ablaciju) radioaktivnim jodom, liječnik će Vam dati radioaktivni jod 24 sata nakon zadnje injekcije lijeka Thyrogen.
English: neoplasm swelling, metastatic pain
Croatian: oticanje novotvorine, metastatska bol
English: In patients with thyroid cancer, several cases of stimulated tumour growth have been reported during withdrawal of thyroid hormones for diagnostic procedures which have been attributed to the associated prolonged elevation of TSH levels.
Croatian: Prijavljeno je nekoliko slučajeva stimulacije rasta tumora u bolesnika s karcinomom štitnjače tijekom razdoblja prekida terapije hormonima štitnjače u svrhu provođenja dijagnostičke obrade, a što se pripisuje produljenom povišenju razine TSH-a.
English: Only one vial of Thyrogen is required per injection.
Croatian: Za jednu injekciju potrebna je samo jedna bočica lijeka Thyrogen.
English: When used as an alternative to thyroid hormone withdrawal, the combination of the whole body scintigraphy (WBS) and Tg testing after Thyrogen administration assures the highest sensitivity for detection of thyroid remnants or cancer.
Croatian: Kad se primjenjuje kao alternativa ukidanju terapije tireoidnim hormonom, najviša osjetljivost pri otkrivanju ostatnog tkiva štitnjače ili karcinoma, osigurava se kombinacijom scintigrafije cijeloga tijela i određivanjem tireoglobulina nakon primjene lijeka Thyrogen.
English: • prickling or tingling sensation (paraesthesia),
Croatian: • osjećaj bockanja ili trnaca (parestezija)
English: The recommended dose regimen of Thyrogen is two intramuscular injections of 0.9 mg thyrotropin alfa administered at a 24-hour interval.
Croatian: Preporučeno doziranje lijeka Thyrogen su dvije intramuskularne injekcije tireotropina alfa u dozi od 0,9 mg primijenjene u razmaku od 24 sata.
English: Thyrotropin alfa was non-inferior to thyroid hormone withdrawal for pretherapeutic stimulation in combination with radioiodine for post-surgical ablation of thyroid remnant tissue.
Croatian: Tireotropin alfa nije bio inferioran prekidu terapije tireoidnim hormonom za predterapijsku stimulaciju u kombinaciji s radioaktivnim jodom u svrhu poslijeoperacijske ablacije ostatnog tkiva štitnjače.
English: Tel: +44 (0)845 372 7101
Croatian: Sanofi Tel +44 (0)845 372 7101
English: It is recommended that the Thyrogen solution be injected within three hours.
Croatian: Otopinu lijeka Thyrogen preporučuje se primijeniti u roku od tri sata.
English: Thyrogen is also used with radioiodine treatment to eliminate (ablate) the thyroid tissue left over after surgical removal of the thyroid gland (remnant) in patients who do not have secondary cancer growths (metastases) and who are taking thyroid hormone.
Croatian: Thyrogen se također primjenjuje u kombinaciji s radioaktivnim jodom za odstranjivanje (ablaciju) ostataka tkiva štitnjače nakon kirurškog uklanjanja štitne žlijezde u bolesnika bez sekundarnog rasta karcinoma (metastaza) koji uzimaju hormone štitnjače.
English: Thyrogen 0.9 mg powder for solution for injection
Croatian: Thyrogen 0,9 mg prašak za otopinu za injekciju
English: Thyrogen should not be used during breast-feeding.
Croatian: Thyrogen se ne smije primjenjivati tijekom dojenja.
English: Binding of thyrotropin alfa to TSH receptors on thyroid epithelial cells stimulates iodine uptake and organification, and synthesis and release of thyroglobulin, triiodothyronine (T3) and thyroxine (T4).
Croatian: Vezivanje tireotropina alfa na TSH receptore epitelnih stanica štitnjače stimulira pohranu i organifikaciju joda u štitnjači te sintezu i otpuštanje tireoglobulina,
English: Withdraw 1.0 ml of the Thyrogen solution from the product vial.
Croatian: Iz bočice izvucite 1,0 ml otopine lijeka Thyrogen.
English: HiLo study recurrence rates in patients who prepared for ablation with Thyrogen or Thyroid Hormone Withdrawal
Croatian: Tablica 3. Stopa povrata bolesti u bolesnika koji su pripremani za ablaciju lijekom Thyrogen ili prekidom uzimanja tireoidnog hormona
English: What Thyrogen contains
Croatian: Thyrogen sadrži natrij
English: Patients with renal/hepatic impairment
Croatian: Bolesnici s oštećenjem bubrega/jetre
English: It is recommended that pre-treatment with corticosteroids be considered for patients in whom local tumour expansion may compromise vital anatomic structures.
Croatian: U bolesnika u kojih lokalno širenje tumora može ugroziti vitalne anatomske strukture preporučuje se razmotriti mogućnost primjene kortikosteroida prije liječenja.
English: Thyrogen in combination with diagnostic radioiodine whole body scintigraphy is contra-indicated in pregnancy (see section 4.3), because of the consequent exposure of the foetus to a high dose of radioactive material.
Croatian: Zbog posljedične izloženosti ploda visokoj dozi radioaktivne tvari, Thyrogen je u kombinaciji s dijagnostičkom radiojodnom scintigrafijom cijeloga tijela kontraindiciran u trudnoći (vidjeti dio 4.3).
English: <PC: SN:
Croatian: SN:
English: Gastrointestinal disorders nausea vomiting diarrhoea
Croatian: Poremećaji probavnog sustava mučnina povraćanje proljev
English: Thyrogen should not be given to breast-feeding women.
Croatian: Thyrogen se ne smije davati ženama koje doje.
English: Use of Thyrogen with Tg testing in follow up of post-thyroidectomy well differentiated thyroid cancer patients should be in accordance with official guidelines.
Croatian: Tg tijekom praćenja bolesnika s dobro diferenciranim karcinomom štitnjače nakon tireoidektomije treba se odvijati sukladno važećim smjernicama.
English: Thyrogen is a human thyroid stimulating hormone (TSH) manufactured using biotechnology processes.
Croatian: Thyrogen je ljudski hormon koji stimulira štitnjaču (TSH)
English: Thyrogen 0.9 mg powder for solution for injection Thyrotropin alfa
Croatian: THYROGEN 0,9 mg prašak za otopinu za injekciju tireotropin alfa
English: ESTIMABL1 study recurrence rates in patients who received low or high dose RAI and those who prepared with Thyrogen or THW
Croatian: Stopa povrata bolesti u ispitivanju ESTIMABL1 u bolesnika koji su primili nisku ili visoku dozu radioaktivnog joda i bolesnika pripremanih lijekom Thyrogen ili prekidom uzimanja tireoidnog hormona
English: For radioiodine imaging or ablation, radioiodine administration should be given 24 hours following the final Thyrogen injection.
Croatian: Za radiojodnu scintigrafiju ili ablaciju, radioaktivni se jod mora primijeniti 24 sata nakon zadnje injekcije lijeka Thyrogen.
English: Sodium phosphate monobasic, monohydrate Sodium phosphate dibasic, heptahydrate Sodium chloride
Croatian: manitol natrijev dihidrogenfosfat hidrat natrijev hidrogenfosfat heptahidrat natrijev klorid
English: Respiratory, thoracic and mediastinal disorder dyspnoea
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja dispneja
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati Thyrogen Lijek čuvajte izvan pogleda i dohvata djece.
English: With the use of Thyrogen, the TSH stimulation necessary for radioiodine uptake and thyroglobulin release is achieved while patients are maintained euthyroid on THST, thus avoiding the morbidity associated with hypothyroidism.
Croatian: Primjenom lijeka Thyrogen postiže se stimulacija TSH-om neophodna za nakupljanje radioaktivnog joda i otpuštanje tireoglobulina, a bolesnici istodobno ne prekidaju supresijsku terapiju tireoidnim hormonom i ostaju u eutireozi, čime se izbjegavaju stanja povezana s hipotireozom.
English: • injection site reactions (including: redness, discomfort, itching, local pain or stinging, and an itchy rash)
Croatian: • bol u mišićima ili zglobovima • reakcije na mjestu injekcije (uključujući: crvenilo, nelagodu, svrbež, lokaliziranu bol ili pečenje te osip koji svrbi) • niske vrijednosti TSH-a
English: Thyrogen-stimulated thyroglobulin testing was also performed.
Croatian: Također je provedeno određivanje tireoglobulina nakon stimulacije lijekom Thyrogen.
English: Laryngeal oedema, respiratory distress requiring tracheotomy, and pain at the site of metastasis have also been reported after Thyrogen administration.
Croatian: Nakon primjene lijeka Thyrogen prijavljeni su i laringealni edem, respiratorni distres koji zahtijeva traheotomiju te bol na mjestu metastaza.
English: 2 vials of powder for solution for injection equal to 2 doses to be administered at a 24-hour interval.
Croatian: 1 bočica praška za otopinu za injekciju 2 bočice praška za otopinu za injekciju, što odgovara 2 dozama koje se primjenjuju u razmaku od 24 sata
English: • inability to taste (ageusia)
Croatian: • bol u vratu • gubitak osjeta okusa (ageuzija)
English: Specifically in a Phase III study involving 164 patients the detection rate of tissue of thyroid origin after a Thyrogen thyroglobulin test ranged from 73-87%, whereas, by using thyroglobulin on TSHT it was 42-62% for the same cut-off values and comparable reference standards.
Croatian: 87%, dok je pri određivanju tireoglobulina za vrijeme supresijske terapije tireoidnim hormonom iznosila 42-62%, uz primjenu istih graničnih vrijednosti i usporedivih referentnih standarda.
English: The third patient experienced nausea, vomiting and hot flushes after 3.6 mg IM dose.
Croatian: U trećega bolesnika su se nakon i.m. doze od 3,6 mg javili mučnina, povraćanje i navale vrućine.
English: Intramuscular use.
Croatian: Primjena u mišić.
English: • swelling of the tumour
Croatian: • oticanje tumora
English: Pregnancy Animal reproduction studies have not been conducted with Thyrogen.
Croatian: Nisu provedena istraživanja na životinjama kojima bi se ispitao utjecaj lijeka Thyrogen na njihovu reprodukciju.
English: - If you experience any side effects, talk to your doctor or pharmacist.
Croatian: - Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
English: If a high index of suspicion for metastatic disease persists, a confirmatory withdrawal WBS and Tg testing should be considered.
Croatian: Ako i dalje postoji osnovana sumnja na metastatsku bolest, treba razmisliti o provođenju scintigrafije cijeloga tijela i određivanju tireoglobulina nakon prestanka primjene hormonske terapije, radi potvrde dijagnoze.
English: • shortness of breath
Croatian: • osjećaj lupanja srca
English: Do not use vials exhibiting foreign particles, cloudiness or discoloration.
Croatian: Ne smiju se upotrijebiti bočice u kojima postoje vidljive čestice, koje su zamućene ili su promijenile boju.
English: General disorders and administration site conditions fatigue, asthenia influenza like illness, pyrexia, chills, feeling hot discomfort, pain, pruritus, rash and urticaria at the site of injection
Croatian: zimica, osjećaj vrućine nelagoda, bol, pruritus, osip i urtikarija na mjestu injekcije
English: Thyrogen Thyroid Hormone Withdrawal (THW)
Croatian: Prekid uzimanja tireoidnog hormona
English: This equals 0.9 mg thyrotropin alfa to be injected.
Croatian: To odgovara dozi od 0,9 mg tireotropina alfa koju treba injicirati.
English: In these studies the use of thyroglobulin testing on Thyrogen was found to be more sensitive than thyroglobulin testing on TSHT.
Croatian: U tim je ispitivanjima zapaženo da je osjetljivost tireoglobulinskog testa nakon primjene lijeka
English: The use of Thyrogen allows for radioiodine imaging while patients are euthyroid on thyroid hormone suppression treatment.
Croatian: Primjena lijeka Thyrogen omogućuje radiojodnu scintigrafiju bez prekidanja supresijske terapije tireoidnim hormonom za vrijeme koje su bolesnici u eutireozi.
English: Low risk patients with well-differentiated thyroid carcinoma who have undetectable serum Tg levels on THST and no rh (recombinant human) TSH-stimulated increase of Tg levels may be followed-up by assaying rhTSH-stimulated Tg levels.
Croatian: Niskorizični bolesnici s dobro diferenciranim karcinomom štitnjače koji imaju nemjerljivu razinu Tg u serumu tijekom supresijske terapije tireoidnim hormonom i koji nemaju porast vrijednosti
English: Enlargement of residual thyroid tissue or metastases can occur following treatment with Thyrogen.
Croatian: Nakon liječenja lijekom Thyrogen može doći do povećanja ostatnog tkiva štitnjače ili metastaza.
English: TSH decreased
Croatian: Pretrage snižena vrijednost TSH-a
English: HR: 1.62 [95% CI 0.67 - 3.91], p=0.28
Croatian: Ukupan broj bolesnika s povratom bolesti Stopa povrata bolesti (3 godine) Stopa povrata bolesti (5 godina) Stopa povrata bolesti (7 godina) HR: 1,62 [95% CI 0,67 - 3,91], p=0,28
English: Any unused solution should be discarded.
Croatian: Neupotrijebljenu otopinu treba zbrinuti.
English: Add 1.2 ml water for injection to the Thyrogen powder in the vial.
Croatian: Primijenite aseptičku tehniku Thyrogen prašku u bočici dodajte 1,2 ml vode za injekcije.
English: The closure consists of a siliconised butyl stopper with a tamper proof flip-off cap. Each vial contains 1.1 mg thyrotropin alfa.
Croatian: Zatvarač se sastoji od silikoniziranog butilnog čepa sa "flip-off" zatvaračem s evidencijom otvaranja.
English: Two large prospective randomised studies, the HiLo study (Mallick) and the ESTIMABL1 study (Schlumberger), compared methods of thyroid remnant ablation in patients with differentiated thyroid cancer who had been thyroidectomised.
Croatian: Dva velika prospektivna randomizirana ispitivanja, HiLo (Mallick) i ESTIMABL1 (Schlumberger),
English: This may lead to acute symptoms, which depend on the anatomical location of the tissue e.g. hemiplegia, hemiparesis, loss of vision have occurred in patients with CNS metastases.
Croatian: U bolesnika s metastazama u SŽS-u javili su se, primjerice, hemiplegija, hemipareza ili gubitak vida.
English: Visually inspect the Thyrogen solution in the vial for foreign particles and discoloration.
Croatian: Vizualno pregledajte otopinu lijeka Thyrogen u bočici, kako biste utvrdili sadrži li vidljive čestice i je li promijenila boju.
English: Diagnostic use
Croatian: PRIMJENU LIJEKA
English: Sodium
Croatian: Dojenje
English: For example, hemiplegia, hemiparesis or loss of vision have occurred in patients with CNS metastases.
Croatian: SŽS-u javili su se, primjerice, hemiplegija, hemipareza, gubitak vida.
English: Vascular disorders flushing
Croatian: Krvožilni poremećaji navale crvenila
English: In both studies, patients were randomised to 1 of 4 treatment groups: Thyrogen + 30 mCi
Croatian: U oba su ispitivanja bolesnici randomizirani u 1 od 4 terapijske skupine: Thyrogen + 30 mCi 131I, Thyrogen + 100 mCi 131I, prekid terapije tireoidnim hormonom + 30 mCi 131I ili prekid terapije tireoidnim hormonom + 100 mCi 131I te su ocijenjeni nakon približno 8 mjeseci.
English: Very rare cases of hyperthyroidism (increased activity of the thyroid gland) or atrial fibrillation have been reported when Thyrogen was administered to patients who had not undergone total or partial removal of the thyroid gland.
Croatian: Prijavljeni su vrlo rijetki slučajevi hipertireoze (pojačana aktivnost štitnjače) ili fibrilacije atrija kad je
English: Uncommon (may affect up to 1 in 100 people): • feeling hot
Croatian: Manje često (mogu se javiti u manje 1 na 100 osoba):
English: Fertility
Croatian: Thyrogen
English: Intramuscular injection only.
Croatian: NAČIN I PUT(EVI) PRIMJENE LIJEKA Samo za injekciju u mišić.
English: Recurrence rate (3 years)
Croatian: 6.3 Rok valjanosti
English: For thyroglobulin (Tg) testing, your doctor or nurse will take a serum sample 72 hours after the last injection of Thyrogen.
Croatian: Za određivanje vrijednosti tireoglobulina (Tg), liječnik ili medicinska sestra uzet će Vam uzorak seruma
English: Make sure you and your child are ready!
Croatian: Pobrinite se da ste Vi i Vaše dijete spremni!
English: Before You Start
Croatian: Prije nego što počnete
English: • Put your child in a safe place.
Croatian: • Stavite dijete na sigurno mjesto.
English: This is because it is very important not to be without the medicine, even for a short time.
Croatian: To je zato jer je vrlo važno da ne ostanete bez lijeka, makar i na kratko.
English: Do not stop taking it because:
Croatian: Nemojte ga prestati uzimati zbog sljedećih razloga:
English: After that, you will give it 2 times a day.
Croatian: Nakon toga ćete ga davati dvaput na dan.
English: Put everything in a clean, dry place.
Croatian: Stavite sve na čisto i suho mjesto.
English: • At the request of the the European Medicines Agency
Croatian: • na zahtjev Europske agencije za lijekove;
English: This kit has changed and may be different than the one you have used before.
Croatian: Ovaj se komplet promijenio i može se razlikovati od onoga koji ste koristili prije.
English: • Your child's dose may be different from the one shown in this figure.
Croatian: • Doza Vašeg djeteta može se razlikovati od one prikazane na ovoj slici.
English: 15 to 18 days
Croatian: 15 - 18 dana
English: • The dose will change over time.
Croatian: • Doza će se s vremenom mijenjati.
English: During your child's first week of life, you will give Isentress 1 time a day.
Croatian: Tijekom prvog tjedna djetetova života davat ćete mu Isentress jedanput na dan.
English: • suicide intention or attempt
Croatian: • namjera ili pokušaj samoubojstva
English: Interaction (mechanism, if known)
Croatian: Interakcija (mehanizam, ako je poznat)
English: Stop when you get to the 10 mL mark.
Croatian: Stanite kad dođete do oznake za 10 ml.
English: • If you forget to take a dose, take it as soon as you remember it.
Croatian: • Ako zaboravite uzeti dozu lijeka, uzmite je čim se sjetite.
English: After mixing Isentress, use it within 30 minutes.
Croatian: Nakon što pomiješate Isentress, primijenite ga unutar 30 minuta.
English: a clean glass
Croatian: čista čaša
English: However, breaking the tablets should be avoided whenever possible.
Croatian: Ipak, lomljenje tableta treba izbjegavati kad god je to moguće.
English: Birth - 48 hours
Croatian: Rođenje - 48 sati
English: Make sure the sachet is completely empty.
Croatian: Provjerite je li vrećica potpuno prazna.
English: Talk to your doctor about other antacids you can take.
Croatian: Razgovarajte s liječnikom o drugim antacidima koje možete uzimati.
English: • Instructions (this booklet)
Croatian: • upute (ova knjižica)
English: You will need both hands to prepare Isentress.
Croatian: Trebat će Vam obje ruke za pripremu lijeka Isentress.
English: Pull the plungers out of any syringes you used.
Croatian: Izvadite klipove iz svih štrcaljki koje ste koristili.
English: Sweeteners contained in this medicine may be harmful to teeth.
Croatian: Sladila u ovom lijeku mogu štetiti zubima.
English: Remember that the dose may change each time you go to the doctor, so make sure you have all the recent information.
Croatian: Zapamtite da se doza može mijenjati pri svakom posjetu liječniku, pa se pobrinite da imate sve najnovije informacije.
English: See section 5.2 regarding the limited data on which these dose recommendations are based.
Croatian: Vidjeti dio 5.2 za ograničene podatke na kojima se temelje ove preporuke za doziranje.
English: Additional formulations and strengths available
Croatian: Dodatni dostupni oblici i jačine
English: This means that you may keep getting infections or other illnesses associated with HIV.
Croatian: To znači da i dalje možete obolijevati od infekcija ili drugih bolesti povezanih sa zarazom HIV-om.
English: Do not use any damaged cups or syringes.
Croatian: Nemojte koristiti oštećene čaše ili štrcaljke.
English: Taking Isentress with food and drink See section 3.
Croatian: Isentress s hranom i pićem Vidjeti dio 3.
English: IMPORTANT: If your child does not take all of the prescribed dose or spits some of it out, call your doctor to find out what to do.
Croatian: VAŽNO: Ako Vaše dijete ne popije cijelu propisanu dozu ili ispljune jedan dio, nazovite svog liječnika i pitajte ga što učiniti.
English: No data are available in this population and no dosing recommendations can be made.
Croatian: Nema dostupnih podataka o primjeni u toj populaciji i ne mogu se dati preporuke za doziranje.
English: Make sure to follow the instructions of your doctor.
Croatian: Obavezno slijedite liječnikove upute.
English: • anaemia including due to low iron
Croatian: • anemiju, uključujući onu uzrokovanu niskom razinom željeza
English: • certain kinds of rash (more often when used in combination with darunavir)
Croatian: • neke vrste osipa (češće se javljaju kad se uzima u kombinaciji s darunavirom)
English: After reconstitution: 30 minutes when stored at or below 30 C.
Croatian: Nakon rekonstitucije: 30 minuta ako se čuva na temperaturi od ili ispod 30ºC.
English: • signs and symptoms of infection or inflammation
Croatian: • znakove i simptome infekcije ili upale
English: If your child fusses, take the tip of the syringe out of the mouth and try again.
Croatian: Ako se dijete bude meškoljilo, izvadite štrcaljku iz usta i pokušajte ponovno.
English: Two tablets once a day
Croatian: Dvije tablete jedanput na dan
English: During a short break in taking the medicine the amount of virus in your blood may increase.
Croatian: Naime, tijekom kratkog prekida uzimanja lijeka količina virusa u krvi može se povećati.
English: • Take out what you need to make 1 dose and place on a clean surface:
Croatian: • Izvadite sav pribor koji Vam je potreban za pripremu 1 doze i položite ga na čistu površinu:
English: Virologic failure
Croatian: Virološki neuspjeh
English: After administration of the required volume, the remaining suspension in the mixing cup cannot be reused and must be discarded.
Croatian: Nakon primjene potrebnog volumena, preostala suspenzija u čaši za miješanje ne može se ponovno upotrijebiti te se mora zbrinuti.
English: Place the tip of the syringe inside your child's mouth so that it touches either the right or left cheek.
Croatian: Stavite vrh štrcaljke djetetu u usta, tako da dodiruje desni ili lijevi obraz.
English: Gender, race, ethnicity and body weight
Croatian: Spol, rasa, etničko podrijetlo i tjelesna težina
English: Keep the booklet and follow it each time you prepare the medicine.
Croatian: Sačuvajte tu knjižicu i slijedite upute svaki put kad pripremate lijek.
English: The virus produces an enzyme called HIV integrase.
Croatian: Virus proizvodi enzim koji se naziva HIV integraza.
English: Do not chew, crush or split the tablets because it may change the level of medicine in your body.
Croatian: Nemojte žvakati, drobiti niti lomiti tablete jer to može promijeniti razinu lijeka u tijelu.
English: Stop when you get to the line that matches your child's prescribed dose.
Croatian: Stanite kada dođete do linije koja odgovara dozi propisanoj Vašem djetetu.
English: PET/aluminium/LLDPE sachets.
Croatian: PET/aluminij/LLDPE vrećice.
English: The mixture should look cloudy.
Croatian: Mješavina mora izgledati mutno.
English: Serious side effects - these are uncommon (may affect up to 1 in 100 people) See a doctor immediately, if you notice any of the following:
Croatian: Ozbiljne nuspojave - one su manje česte (mogu se javiti u do 1 na 100 osoba) Odmah se javite liječniku ako primijetite bilo što od sljedećeg:
English: • hot flush; high blood pressure
Croatian: • navale vrućine; povišen krvni tlak
English: Do not take more tablets than the doctor recommends.
Croatian: Nemojte uzeti više tableta nego što je preporučio liječnik.
English: • The granules need to be mixed with water before use.
Croatian: • Granule se prije primjene moraju pomiješati s vodom.