FrancophonIA/ELRC3.0 huggingface dataset:
English: • of these symptoms seek medical advice immediately;
Croatian: Ako primijetite bilo koji od ovih simptoma odmah zatražite liječnički savjet;
English: Do not use this medicine after the expiry date, which is stated on the carton or label after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji ili naljepnici iza EXP.
English: The pharmacokinetic variability observed in the elderly is within the range for the non-elderly.
Croatian: Farmakokinetička varijabilnost uočena u starijih osoba je unutar raspona za mlađe osobe.
English: Olanzapine is bound predominantly to albumin and 1-acid-glycoprotein.
Croatian: Olanzapin se prvenstveno veže na albumin i 1-acidni-glikoprotein.
English: You should not be given this medicine when breast-feeding, as small amounts of olanzapine can pass into breast milk.
Croatian: Ovaj lijek ne smijete uzimati ako dojite, jer mala količina olanzapina može prijeći u majčino mlijeko.
English: Patients who have taken more olanzapine than they should have experienced the following symptoms: rapid beating of the heart, agitation/aggressiveness, problems with speech, unusual movements (especially of the face or tongue) and reduced level of consciousness.
Croatian: Bolesnici koji su uzeli više olanzapina nego što su trebali imaju sljedeće simptome: ubrzani rad srca, uznemirenost/agresivnost, problemi s govorom, neuobičajeni pokreti (osobito lica ili jezika) i snižena razina svijesti.
English: Cardiovascular monitoring is necessary to detect possible arrhythmias.
Croatian: Za otkrivanje mogućih aritmija neophodno je kardiovaskularno praćenje.
English: Clinically significant weight gain was observed across all baseline Body Mass Index (BMI) categories.
Croatian: 1 Klinički značajno povećanje tjelesne težine uočeno je u svim početnim kategorijama indeksa tjelesne mase (BMI).
English: Hepatitis (including hepatocellular, cholestatic or mixed liver injury)11
Croatian: hepatitis (uključujući hepatocelularno, kolestatsko ili mješovito oštećenje jetre)11
English: Although no clinical studies designed to compare adolescents to adults have been conducted, data from the adolescent trials were compared to those of the adult trials.
Croatian: Iako nisu provedena klinička ispitivanja namijenjena usporedbi odraslih i adolescenata, uspoređeni su podaci iz ispitivanja adolescenata s podacima iz ispitivanja odraslih osoba.
English: As a routine precaution, if you are over 65 years your blood pressure may be monitored by your doctor.
Croatian: Ako ste stariji od 65 godina liječnik će Vam, kao rutinsku mjeru opreza, redovito kontrolirati krvni tlak.
English: The metabolism of olanzapine may be induced by smoking and carbamazepine, which may lead to reduced olanzapine concentrations.
Croatian: Metabolizam olanzapina može se inducirati pušenjem i karbamazepinom, što može dovesti do smanjenja koncentracije olanzapina.
English: Because olanzapine may cause somnolence and dizziness, patients should be cautioned about operating machinery, including motor vehicles.
Croatian: S obzirom da olanzapin može uzrokovati somnolenciju i omaglicu, bolesnici moraju biti oprezni kod upravljanja strojevima, uključujući motorna vozila.
English: If you take more Olanzapine Mylan than you should
Croatian: Ako uzmete više Olanzapine Mylan nego što ste trebali
English: Clinically significant weight gain (≥ 7 %) appears to occur more frequently in the adolescent population compared to adults with comparable exposures.
Croatian: Čini se da se klinički značajno povećanje tjelesne težine (≥ 7 %) češće javlja u populaciji adolescenata u usporedbi s odraslim osobama s usporedivim izlaganjima lijeku.
English: In patients with Parkinson's disease Olanzapine Mylan may worsen the symptoms.
Croatian: U bolesnika koji boluju od Parkinsonove bolesti, Olanzapine Mylan može pogoršati simptome.
English: It is important that you carry on taking Olanzapine Mylan for as long as your doctor tells you.
Croatian: Važno je da nastavite uzimati Olanzapine Mylan onoliko dugo koliko Vam je liječnik rekao.
English: Manic episode: The starting dose is 15 mg as a single daily dose in monotherapy or 10 mg daily in combination therapy (see section 5.1).
Croatian: Epizoda manije: početna doza je 15 mg primjenjena kao jednokratna dnevna doza u monoterapiji ili 10 mg dnevno u kombinacijskoj terapiji (vidjeti dio 5.1).
English: Dystonia (including oculogyration)11
Croatian: distonija (uključujući okulogiraciju)11
English: • Heart disease
Croatian: • Bolest srca
English: In adult patients who completed 9-12 months of therapy, the rate of increase in mean blood glucose slowed after approximately 6 months.
Croatian: U odraslih bolesnika koji su nakon 9-12 mjeseci završili liječenje, stopa povećanja srednje vrijednosti glukoze u krvi smanjila se nakon 6 mjeseci.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljne informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu.
English: Fatal outcomes have been reported for acute overdoses as low as 450 mg but survival has also been reported following acute overdose of approximately 2 g of oral olanzapine.
Croatian: Zabilježeni su i smrtni ishodi kod akutnog predoziranja već pri maloj dozi od 450 mg, ali opisano je i preživljavanje nakon akutnog predoziranja od oko 2 g oralnog olanzapina.
English: Possible side effects Like all medicines, this medicine can cause side effects, although not everybody gets them.
Croatian: Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave, iako se neće razviti kod svakoga.
English: The mean increase in olanzapine Cmax following fluvoxamine was 54 % in female nonsmokers and 77 % in male smokers.
Croatian: Srednja vrijednost porasta Cmax olanzapina, nakon primjene fluvoksamina, iznosila je 54 % u žena nepušača i 77 % u muškaraca pušača.
English: What Olanzapine Mylan is and what it is used for
Croatian: Što je Olanzapine Mylan i za što se koristi
English: Very common: Weight gain13, elevated triglyceride levels14, increased appetite.
Croatian: Vrlo često: Povećanje tjelesne težine13, povišene razine triglicerida14, povećani apetit.
English: In these trials, patients were initially required to be stable on the lowest effective dose of antiParkinsonian medicinal products (dopamine agonist) and to remain on the same anti-Parkinsonian medicinal products and dosages throughout the study.
Croatian: Na početku ovih ispitivanja bolesnici su morali biti stabilni na najnižoj učinkovitoj dozi antiparkinsonika (agonisti dopamina) te su na istom antiparkinsoniku i pri istoj dozi morali ostati tijekom cijelog ispitivanja.
English: What Olanzapine Mylan is and what it is used for What you need to know before you take Olanzapine Mylan How to take Olanzapine Mylan Possible side effects
Croatian: Što je Olanzapine Mylan i za što se koristi Što morate znati prije nego počnete uzimati Olanzapine Mylan Kako uzimati Olanzapine Mylan Moguće nuspojave
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja galaktoze, manjkom Lapp laktaze ili malapsorpcijom glukoze-galaktoze ne smiju uzimati ovaj lijek.
English: Children and adolescents Olanzapine Mylan is not for patients who are under 18 years.
Croatian: Djeca i adolescenti Olanzapine Mylan nije za primjenu u bolesnika mlađih od 18 godina.
English: • carbamazepine (an anti-epileptic and mood stabiliser), fluvoxamine (an antidepressant) or ciprofloxacin (an antibiotic) - it may be necessary to change your Olanzapine Mylan dose.
Croatian: • karbamazepin (antiepileptik i stabilizator raspoloženja), fluvoksamin (antidepresiv) ili ciprofloksacin (antibiotik) - možda će biti potrebno promijeniti dozu Olanzapine Mylan.
English: • Stroke or “mini” stroke (temporary symptoms of stroke)
Croatian: • Moždani udar ili „mali” moždani udar (kratkotrajni simptomi moždanog udara)
English: A lower starting dose (5 mg/day) is not routinely indicated but should be considered for those 65 and over when clinical factors warrant (see section 4.4).
Croatian: Niža početna doza (5 mg/dan) nije rutinski indicirana, no treba ju razmotriti u osoba u dobi od 65 godina i starijim, kada to opravdavaju klinički čimbenici (vidjeti dio 4.4).
English: In cases of moderate hepatic insufficiency (cirrhosis, Child-Pugh Class A or B), the starting dose should be 5 mg and only increased with caution.
Croatian: U slučajevima umjerene insuficijencije jetre (ciroza, Child-Pugh stadij A ili B), početna doza treba biti 5 mg i može se povećati samo uz oprez.
English: Patients should be advised not to breast feed an infant if they are taking olanzapine.
Croatian: Bolesnice treba savjetovati da ne doje dijete ako uzimaju olanzapin.
English: An allergic reaction may be recognised as a rash, itching, a swollen face, swollen lips or shortness of breath.
Croatian: Alergijska reakcija može se prepoznati kao osip, svrbež, otečeno lice, otečene usnice ili nedostatak zraka.
English: The frequency terms listed are defined as follows: Very common (≥ 1/10), common (≥ 1/100 to
Croatian: Navedene učestalosti definirane su kako slijedi: vrlo često (≥ 1/10), često (≥ 1/100 do < 1/10).
English: Symptomatic treatment and monitoring of vital organ function should be instituted according to clinical presentation, including treatment of hypotension and circulatory collapse and support of respiratory function.
Croatian: Simptomatsko liječenje i praćenje funkcije vitalnih organa treba započeti prema kliničkoj slici, uključujući liječenje hipotenzije i cirkulatornog kolapsa te potpore respiratorne funkcije.
English: A mass balance study showed that approximately 57 % of radiolabelled olanzapine appeared in urine, principally as metabolites.
Croatian: Ispitivanje masene bilance pokazalo je da se oko 57 % olanzapina označenog radioizotopom pojavljuje u mokraći, uglavnom u obliku metabolita.
English: Therapeutic monitoring of valproate plasma levels did not indicate that valproate dosage adjustment is required after the introduction of concomitant olanzapine.
Croatian: Terapijsko praćenje razina valproata u plazmi nije indiciralo na potrebu za prilagođavanjem doze valproata nakon početka istodobne primjene olanzapina.
English: Sudden cardiac death
Croatian: Iznenadna srčana smrt
English: Inhibition of CYP1A2
Croatian: Inhibicija CYP1A2
English: Preventing recurrence in bipolar disorder: The recommended starting dose is 10 mg/day.
Croatian: Sprječavanje relapsa bipolarnog poremećaja: preporučena početna doza je 10 mg/dan.
English: During treatment for schizophrenia, manic episode and recurrence prevention in bipolar disorder, daily dosage may subsequently be adjusted on the basis of individual clinical status within the range 5-20 mg/day.
Croatian: Tijekom liječenja shizofrenije, epizode manije te prevencije relapsa bipolarnog poremećaja, dnevna doza se može naknadno podesiti na temelju pojedinačne kliničke slike u rasponu od 5 do 20 mg/dan.
English: Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during treatment with olanzapine.
Croatian: Bolesnice treba savjetovati da obavijeste svog liječnika ako tijekom liječenja olanzapinom ostanu trudne ili planiraju trudnoću.
English: However, the incidence of death was higher in olanzapine-treated than in placebo-treated patients independent of these risk factors.
Croatian: Međutim, incidencija smrtnosti bila je veća u bolesnika liječenih olanzapinom nego u bolesnika liječenih placebom, neovisno o ovim čimbenicima rizika.
English: If a patient develops signs and symptoms indicative of NMS, or presents with unexplained high fever without additional clinical manifestations of NMS, all antipsychotic medicines, including olanzapine must be discontinued.
Croatian: Ako se u bolesnika pojave znakovi i simptomi karakteristični za NMS ili se pojavi neuobičajeno visoka temperatura s dodatnim kliničkim manifestacijama NMS-a, potrebno je prekinuti terapiju svim antipsihotičnim lijekovima, uključujući olanzapin.
English: Mean infant exposure (mg/kg) at steady state was estimated to be 1.8 % of the maternal olanzapine dose (mg/kg).
Croatian: Prosječna izloženost novorođenčeta (mg/kg) u stanju dinamičke ravnoteže procijenjena je na 1,8 % majčine doze olanzapina (mg/kg).
English: Very common side effects (may affect more than 1 in 10 people) include weight gain; sleepiness; and increases in levels of prolactin in the blood.
Croatian: Vrlo česte nuspojave (mogu se pojaviti u više od 1 na 10 osoba) uključuju povećanje tjelesne težine; pospanost i povišene razine prolaktina u krvi.
English: In studies up to 3 months duration in mice and up to 1 year in rats and dogs, the predominant effects were CNS depression, anticholinergic effects, and peripheral haematological disorders.
Croatian: U ispitivanjima u trajanju do 3 mjeseca na miševima te do godine dana na štakorima i psima, prevladavajući učinci bili su depresija središnjeg živčanog sustava (SŽS), antikolinergični učinci i periferni hematološki poremećaji.
English: Amnesia9
Croatian: amnezija9
English: The following symptoms may occur in newborn babies of mothers that have used Olanzapine Mylan in the last trimester (last three months of their pregnancy): shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding.
Croatian: Sljedeći simptomi mogu se pojaviti u novorođenčadi majki koje su koristile Olanzapine Mylan u posljednjem tromjesečju (zadnja tri mjeseca trudnoće): drhtanje, ukočenost mišića i/ili slabost, pospanost, uznemirenost, problemi s disanjem te poteškoće u hranjenju.
English: The absorption is not affected by food.
Croatian: Hrana ne utječe na apsorpciju.
English: In the absence of detailed information on the pre-existing history of individual acute and tardive extrapyramidal movement disorders, it cannot be concluded at present that olanzapine produces less tardive dyskinesia and/or other tardive extrapyramidal syndromes.
Croatian: U nedostatku detaljnih informacija u anamnezi o prethodno postojećim individualnim akutnim i tardivnim ekstrapiramidalnim poremećajima kretanja, u ovom se trenutku ne može zaključiti da olanzapin dovodi do manje učestalosti tardivne diskinezije i/ili ostalih tardivnih ekstrapiramidalnih sindroma.
English: Electrophysiological studies demonstrated that olanzapine selectively reduced the firing of mesolimbic (A10) dopaminergic neurons, while having little effect on the striatal (A9) pathways involved in motor function.
Croatian: Elektrofiziološka ispitivanja pokazala su da olanzapin selektivno smanjuje izbijanje mezolimbičkih (A10) dopaminergičkih neurona, a nema većeg učinka na strijatalne (A9) puteve uključene u motoričku funkciju.
English: Very common: Decreased total bilirubin, increased GGT, elevated plasma prolactin levels16.
Croatian: Vrlo često: Smanjenje ukupnog bilirubina, povećan GGT, povišene razine prolaktina u plazmi16.
English: In monkeys, single oral doses up to 100 mg/kg resulted in prostration and, at higher doses, semi-consciousness.
Croatian: U majmuna je pojedinačna oralna doza do 100 mg/kg dovodila do prostracije, a u većim dozama do polusvjesnog stanja.
English: In the early stages of treatment, some people may feel dizzy or faint (with a slow heart rate), especially when getting up from a lying or sitting position.
Croatian: U ranim fazama liječenja neki bolesnici mogu osjećati omaglicu ili nesvjesticu (uz usporen rad srca), posebno pri uspravljanju iz ležećeg ili sjedećeg položaja tijela.
English: Consult your doctor if your symptoms return but do not stop taking Olanzapine Mylan unless your doctor tells you to.
Croatian: Ako Vam se simptomi vrate, posavjetujte se sa svojim liječnikom, ali nemojte prestati uzimati Olanzapine Mylan dok Vam liječnik to ne kaže.
English: Olanzapine was used as a flexible dose starting with 2.5 and ranging up to 20 mg/day.
Croatian: Olanzapin se primjenjivao kao fleksibilna doza koja je započinjala s 2,5 mg dnevno i postupno je povećavana do 20 mg dnevno.
English: Acute (single-dose) toxicity
Croatian: Akutna toksičnost (jedna doza)
English: However the risk of tardive dyskinesia increases with long term exposure, and therefore if signs or symptoms of tardive dyskinesia appear in a patient on olanzapine, a dose reduction or discontinuation should be considered.
Croatian: Međutim, rizik pojave tardivne diskinezije povećava se s dugotrajnom izloženošću te u slučaju pojave znakova ili simptoma tardivne diskinezije u bolesnika na olanzapinu treba razmotriti snižavanje doze ili prekid liječenja.
English: Olanzapine does not inhibit the main CYP450 isoenzymes in vitro (e.g. 1A2, 2D6, 2C9, 2C19, 3A4).
Croatian: Olanzapin ne inhibira glavne izoenzime CYP450 in vitro (npr. 1A2, 2D6, 2C9, 2C19, 3A4).
English: • If you know that you may have salt depletion as a result of prolonged severe diarrhoea and vomiting (being sick) or usage of diuretics (water tablets)
Croatian: • Ako znate da možda imate nedovoljno soli u organizmu kao posljedicu dugotrajnog teškog proljeva i povraćanja ili zbog uzimanja diuretika (tableta za izlučivanje vode iz organizma)
English: While olanzapine demonstrated anticholinergic activity in vitro, experience during the clinical trials revealed a low incidence of related events.
Croatian: Dok olanzapin in vitro pokazuje antikolinergičko djelovanje, iskustvo tijekom kliničkih ispitivanja otkrilo je nisku incidenciju povezanih događaja.
English: However, since patients with schizophrenia often present with acquired risk factors for venous thromboembolism all possible risk factors of VTE e.g. immobilisation of patients, should be identified and preventive measures undertaken.
Croatian: Međutim, budući da bolesnici sa shizofrenijom često imaju stečene čimbenike rizika za vensku tromboemboliju, sve moguće čimbenike rizika VTE npr. imobilizacija bolesnika, treba identificirati te poduzeti preventivne mjere.
English: Do not drink any alcohol if you have been given Olanzapine Mylan as together with alcohol it may make you feel drowsy.
Croatian: Nemojte piti alkohol tijekom uzimanja Olanzapine Mylan, jer u kombinaciji s alkoholom može Vam izazvati pospanost.
English: Acute symptoms such as sweating, insomnia, tremor, anxiety, nausea, or vomiting have been reported rarely (≥ 0.01 % and < 0.1 %) when olanzapine is stopped abruptly.
Croatian: Akutni simptomi kao što su znojenje, nesanica, tremor, anksioznost, mučnina ili povraćanje rijetko su zabilježeni (≥ 0,01 % i < 0,1 %) nakon naglog prekida uzimanja olanzapina.
English: • Schizophrenia, a disease with symptoms such as hearing, seeing or sensing things which are not there, mistaken beliefs, unusual suspiciousness, and becoming withdrawn.
Croatian: • Shizofrenije, bolesti sa simptomima kao što su slušna, vidna ili osjetilna priviđenja stvari koje nisu prisutne, iluzije, neuobičajena sumnjičavost i povučenost.
English: Olanzapine also showed a statistically significant advantage over placebo in terms of preventing either recurrence into mania or recurrence into depression.
Croatian: Olanzapin je također pokazao statistički značajnu prednost nad placebom u sprječavanju relapsa manije ili relapsa depresije.
English: A decrease in the dose of olanzapine should be considered if treatment with an inhibitor of CYP1A2 is initiated.
Croatian: Smanjenje doze olanzapina treba razmotriti u slučaju da se započinje liječenje inhibitorom CYP1A2.
English: In most of these cases, a history of seizures or risk factors for seizures were reported.
Croatian: U većini tih slučajeva zabilježeni su u anamnezi napadaji ili čimbenici rizika za nastanak napadaja.
English: Controlled efficacy data in adolescents (ages 13 to 17 years) are limited to short term studies in schizophrenia (6 weeks) and mania associated with bipolar I disorder (3 weeks), involving less than 200 adolescents.
Croatian: Podaci o djelotvornosti iz kontroliranih ispitivanja u adolescenata (u dobi od 13 do 17 godina) su ograničeni na kratkotrajna ispitivanja u shizofreniji (6 tjedana) i maniji povezanima s bipolarnim poremećajem I (3 tjedna), obuhvaćajući manje od 200 adolescenata.
English: Olanzapine administered with lithium or valproate resulted in increased levels (10 %) of tremor, dry mouth, increased appetite, and weight gain.
Croatian: Olanzapin primijenjen s litijem ili valproatom rezultirao je povećanim razinama (≥ 10 %) tremora, suhoće usta, povećanjem apetita i povećanjem tjelesne težine.
English: The magnitude of weight gain and the proportion of adolescent patients who had clinically significant weight gain were greater with long-term exposure (at least 24 weeks) than with short-term exposure.
Croatian: Povećanje tjelesne težine i omjer adolescentnih bolesnika koji su imali klinički značajno povećanje tjelesne težine bili su veći tijekom dugotrajnog izlaganja (najmanje 24 tjedana) nego tijekom kratkotrajnog izlaganja lijeku.
English: • Blood disorders
Croatian: • Poremećaji krvi
English: Olanzapine reduced a conditioned avoidance response, a test indicative of antipsychotic activity, at doses below those producing catalepsy, an effect indicative of motor side-effects.
Croatian: Olanzapin smanjuje uvjetovani odgovor izbjegavanja, test koji je indikativan za antipsihotičnu aktivnost, pri dozama nižima od onih koje uzrokuju katalepsiju, učinak indikativan za motoričke nuspojave.
English: Lipid alterations should be managed as clinically appropriate, particularly in dyslipidemic patients and in patients with risk factors for the development of lipids disorders.
Croatian: Promjene lipida treba prikladno klinički liječiti, posebno u bolesnika s dislipidemijom ili u bolesnika s čimbenicima rizika za razvoj poremećaja lipida.
English: Olanzapine should be used cautiously in patients who have a history of seizures or are subject to factors which may lower the seizure threshold.
Croatian: Olanzapin treba oprezno primjenjivati u bolesnika koji su imali u anamnezi napadaje ili su izloženi čimbenicima koji mogu sniziti prag za napadaje.
English: Marketing Authorisation Holder Mylan S.A.S., 117 Allée des Parcs, 69800 Saint-Priest, France.
Croatian: Nositelj odobrenja za stavljanje lijeka u promet Mylan S.A.S., 117 Allée des Parcs, 69800 Saint-Priest, Francuska.
English: If this has happened to you, tell your doctor.
Croatian: Ako Vam se ovo pojavi, obavijestite svog liječnika.
English: Caution should be used if olanzapine is being administered concomitantly with medicinal products known to increase QTc interval (see section 4.4).
Croatian: Potreban je oprez ako se olanzapin primjenjuje istodobno s lijekovima za koje se zna da povećavaju QTc interval (vidjeti dio 4.4).
English: Induction of CYP1A2
Croatian: Indukcija CYP1A2
English: In preclinical studies, olanzapine exhibited a range of receptor affinities (Ki < 100 nM) for serotonin 5 HT2A/2C, 5 HT3, 5 HT6; dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; α1 adrenergic; and histamine H1 receptors.
Croatian: U pretkliničkim ispitivanjima, olanzapin je pokazao raspon afiniteta za receptore (Ki < 100 nM) serotonina 5 HT2A/2C, 5 HT3, 5 HT6; dopamina D1, D2, D3, D4, D5; kolinergičke muskarinske receptore M1-M5; α1 adrenergičke; i histaminske H1 receptore.
English: The daily dose of olanzapine is between 5 mg and 20 mg.
Croatian: Dnevna doza Olanzapine Mylan iznosi između 5 mg i 20 mg.
English: If this happens after you have been given Olanzapine Mylan tell your doctor.
Croatian: Ako Vam se ovo pojavi nakon uzimanja Olanzapine Mylan, obratite se svom liječniku.
English: Olanzapine Mylan with alcohol
Croatian: Olanzapine Mylan s alkoholom
English: In a retrospective observational cohort study, the risk of presumed sudden cardiac death in patients treated with olanzapine was approximately twice the risk in patients not using antipsychotics.
Croatian: U retrospektivnom opservacijskom kohortnom ispitivanju, rizik pretpostavljene iznenadne srčane smrti u bolesnika liječenih olanzapinom bio je otprilike dvostruko veći nego u bolesnika koji nisu uzimali antipsihotike.