FrancophonIA/ELRC3.0 huggingface dataset:
English: † Includes subjects who discontinued prior to Week 48 for lack or loss of efficacy and subjects who are ≥50 copies in the 48 week window.
Danish: † Omfatter personer, der fik seponeret behandlingen før uge 48 på grund af manglende eller tab af effekt, og personer med ≥ 50 kopier inden for tidsrammen på de 48 uger.
English: • phenytoin and phenobarbital, to treat epilepsy
Danish: • phenytoin og phenobarbital til behandling af epilepsi.
English: For the comparators typical resistance was detected with TDF/FTC/EFV (SINGLE; six with NNRTI associated resistance and one with major NRTI resistance) and with 2 NRTIs + raltegravir (SPRING2; four with major NRTI resistance and one with raltegravir resistance), while no de novo resistance was detected in patients treated with 2 NRTIs + DRV/RTV (FLAMINGO).
Danish: For komparatorerne blev typisk resistens set med TDF/FTC/EFV (SINGLE: 6 med NNRTI-relateret resistens og 1 med udtalt NRTI-resistens) og med 2 NRTI'er + raltegravir (SPRING-2: 4 med udtalt NRTI-resistens og 1 med raltegravir-resistens), mens der ikke blev set nogen de novo-resistens hos de patienter, der blev behandlet med 2 NRTI'er + DRV/RTV (FLAMINGO).
English: In patients with mild hepatic impairment (Child-Pugh score 5-6) close monitoring is required, including monitoring of abacavir plasma levels if feasible (see sections 4.4 and 5.2).
Danish: Hos patienter med let nedsat leverfunktion (Child-Pugh-klasse 5-6) er tæt monitorering påkrævet, herunder monitorering af plasmaniveauer af abacavir, hvis muligt (se pkt.
English: • supplements or multivitamins containing calcium, iron or magnesium.
Danish: • kosttilskud eller multivitaminpræparaterer, der indeholder calcium, jern eller magnesium.
English: Dolutegravir is also a substrate of UGT1A3, UGT1A9, CYP3A4, Pglycoprotein (P-gp), and breast cancer resistance protein (BCRP).
Danish: Dolutegravir er også et substrat for UGT1A3, UGT1A9, CYP3A4, P-glycoprotein (Pgp) og brystkræftresistentprotein (BCRP).
English: SIDE 2 You should immediately contact your doctor if you think you are having a hypersensitivity reaction to Triumeq.
Danish: Du skal straks kontakte lægen, hvis du tror, at du har en overfølsomhedsreaktion over for Triumeq.
English: Symptoms have included rash, constitutional findings, and sometimes, organ dysfunction, including severe liver reactions.
Danish: Symptomerne har omfattet udslæt, konstitutionelle fund og nogle gange organdysfunktion, herunder alvorlige leverreaktioner.
English: Interactions between dolutegravir, abacavir, lamivudine and co-administered medical products are listed in Table 1 (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, area under the concentration versus time curve as “AUC”, maximum observed concentration as “Cmax”).
Danish: Interaktioner mellem dolutegravir, abacavir, lamivudine og samtidigt administrerede lægemidler er anført i tabel 1 (stigning er angivet som "↑", fald som "↓", ingen ændring som "↔", arealet under kurven over koncentration som funktion af tid som "AUC" og den observerede maksimumskoncentration som "Cmax").
English: Twenty out of 23 children and adolescents (87%) had >1 log10 c/mL decrease from Baseline in HIV-1 RNA or HIV-1 RNA <400 c/mL at Week 24.
Danish: 20 ud af 23 børn og unge (87 %) havde et fald på > 1 log10 kopier/ml i forhold til baseline i hiv-1RNA eller hiv-1-RNA < 400 kopier/ml i uge 24.
English: After 24 weeks all remaining subjects switched to ABC/DTG/3TC FDC (Late Switch).
Danish: Efter 24 uger skiftede alle tilbageværende patienter til ABC/DTG/3TC FDC (sent skift).
English: Of these four, two subjects had a unique R263K integrase substitution, with a maximum fold change of 1.93, one subject had a polymorphic V151V/I integrase substitution, with maximum fold change of 0.92, and one subject had pre-existing integrase mutations and is assumed to have been integrase experienced or infected with integrase resistant virus by transmission.
Danish: Af disse 4 havde 2 personer en unik R263K-integrasesubstitution, med en FC på maksimalt 1,93, 1 person havde en polymorf V151V/I-integrasesubstitution, med en FC på maksimalt 0,92, og 1 person havde præeksisterende integrasemutationer og anses for at have været integraseerfaren eller inficeret med integraseresistent virus ved overførsel.
English: → Read the information ‘Other possible side effects of combination therapy for HIV' in Section 4 of this leaflet.
Danish: → Læs oplysningerne under 'Andre mulige bivirkninger ved kombinationsbehandling af hiv' i punkt 4 i denne indlægsseddel.
English: Virologic suppression (HIV-1 RNA <50 copies/mL) in the ABC/DTG/3TC FDC group (85%) was statistically non-inferior to the current ART groups (88%) at 24 weeks.
Danish: Virologisk suppression (HIV-1-RNA <50 kopier / ml) i ABC/DTG/3TC FDC-gruppen (85 %) var statistisk non-inferior til de aktuelle ART-grupper (88 %) efter 24 uger.
English: Dolutegravir, abacavir and lamivudine have been shown to inhibit replication of lab-strains and clinical isolates of HIV in a number of cell types, including transformed T cell lines, monocyte/macrophage derived lines and primary cultures of activated peripheral blood mononuclear cells (PMBCs) and monocyte/macrophages.
Danish: Dolutegravir, abacavir og lamivudin har vist sig at hæmme replikation af laboratoriestammer og kliniske isolater af hiv i en række celletyper, herunder transformerede T-cellelinjer, linjer stammende fra monocytter/makrofager og primærkulturer af aktiverede mononukleære celler fra perifert blod (PMBC'er) samt monocytter/makrofager.
English: Triumeq can be taken with or without food.
Danish: Triumeq kan indtages med eller uden mad.
English: Occasionally, hypersensitivity reactions have developed in people who start taking abacavir containing products again, but who had only one symptom on the Alert Card before they stopped taking it.
Danish: I nogle tilfælde er overfølsomhedsreaktioner opstået hos personer, som genoptog behandlingen med lægemidler, der indeholdt abacavir, men som kun havde haft ét af symptomerne på oplysningskortet, før de stoppede med at tage medicinen.
English: If you have stopped taking Triumeq for any reason - especially because you think you are having side effects, or because you have another illness:
Danish: Hvis du er holdt op med at tage Triumeq af en eller anden grund - særligt hvis det er, fordi du mener, at du får bivirkninger, eller fordi du har en anden sygdom:
English: Ethanol/Abacavir (0.7 g/kg single dose/600mg single dose)
Danish: Ethanol/abacavir (0,7 g/kg enkeltdosis/600 mg enkeltdosis)
English: The primary effect of dolutegravir was gastrointestinal intolerance or irritation in rats and monkeys at doses that produce systemic exposures approximately 38 and 1.5 times the 50 mg human clinical exposure based on AUC, respectively.
Danish: Den primære effekt af dolutegravir var gastrointestinal intolerance eller irritation hos rotter og aber ved doser, der medfører systemiske eksponeringer på henholdsvis ca. 38 og 1,5 gange den humane kliniske eksponering ved 50 mg baseret på AUC.
English: Drug Interactions Medicinal products by therapeutic areas
Danish: Tabel 1 Lægemiddelinteraktioner Lægemidler efter terapeutiske områder
English: The observed values of the peak concentrations are 9-fold greater than the IC50 of abacavir of 0.08 µg/ml or 0.26 µM when abacavir is given at 600 mg twice daily.
Danish: De observerede værdier ved maksimal plasmakoncentration er 9 gange større end IC50 for abacavir, som er 0,08 μg/ml eller 0,26 μM, når der gives 600 mg abacavir to gange daglig.
English: Available toxicological data in animals have shown excretion of dolutegravir in milk.
Danish: De tilgængelige toksikogiske data fra dyrestudier viser, at dolutegravir udskilles i mælk.
English: Resistance in vitro: (dolutegravir)
Danish: Resistens in vitro: (dolutegravir)
English: The adjusted mean change in CD4+ T cell count from baseline were 267 cells versus 208 cells/mm3, respectively (p<0.001).
Danish: Den justerede middelændring i CD4+ T-celletallet i forhold til baseline var henholdsvis 267 celler/mm3 vs. 208 celler/mm3 (p < 0,001).
English: The mean time to maximal serum concentrations (tmax) is about 2 to 3 hours (post dose for tablet formulation), 1.5 hours and 1.0 hour for dolutegravir, abacavir and lamivudine, respectively.
Danish: Den gennemsnitlige tid til maksimale serumkoncentrationer (tmax) er henholdsvis omkring 2-3 timer (efter dosering af tabletformulering), 1,5 timer og 1,0 timer for dolutegravir, abacavir og lamivudin.
English: Patients with chronic hepatitis B or C
Danish: Patienter med kronisk hepatitis B eller C
English: (See ‘Patients with chronic hepatitis B or C' earlier in this section and also see section 4.8).
Danish: (Se 'Patienter med kronisk hepatitis B eller C' tidligere idette afsnit og se også pkt.
English: In serial passage with strain NL432-based site directed mutants at N155H or E92Q, no further selection of resistance was seen (fold change unchanged around 1).
Danish: I seriepassage med stamme NL432, som husede de stedspecifikke mutationer N155H eller E92Q, blev der ikke set nogen yderligere selektion af resistens (FC uændret omkring 1).
English: Dolutegravir ↓ (Not studied, a similar reduction in exposure as observed with efavirenz is expected, due to induction)
Danish: Dolutegravir ↓ (Ikke undersøgt, et lignende fald i eksponering som set med efavirenz forventes, pga. induktion).
English: During in vitro abacavir selection the M184V mutation occurred first and resulted in about a 2-fold increase in IC50, below the abacavir clinical cut-off of 4.5-fold change.
Danish: Under abacavir-selektionen in vitro opstod M184V-mutationen først og resulterede i en fordobling af IC50, under den kliniske skæring for abacavir, som er en FC på 4,5.
English: Store in the original package in order to protect from moisture.
Danish: Opbevares i den originale beholder for at beskytte mod fugt.
English: You may also be told never again to take any other medicine containing dolutegravir.
Danish: Du kan også få at vide, at du aldrig mere må tage nogen lægemidler, der indeholder dolutegravir.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse reactions.
Danish: Patienter med kronisk hepatitis B eller C, behandlet med antiretroviral kombinationsbehandling, har større risiko for alvorlige og potentielt dødelige leverbivirkninger.
English: The safety and efficacy of Triumeq in children less than 12 years of age has not yet been established.
Danish: Sikkerheden og virkningen af Triumeq hos børn under 12 år er endnu ikke klarlagt.
English: Similar reactions have also occurred infrequently after restarting abacavir in patients who had only one of the key symptoms of hypersensitivity (see above) prior to stopping abacavir; and on very rare occasions have also been seen in patients who have restarted therapy with no preceding symptoms of a HSR (i.e., patients previously considered to be abacavir tolerant).
Danish: Der er i sjældne tilfælde også forekommet lignende reaktioner med hurtig indtrædelse efter genoptagelse af behandling med abacavir hos patienter, som kun havde ét af de kendetegnende symptomer på overfølsomhed (se ovenfor), og disse reaktioner er også i meget sjældne tilfælde set hos patienter, som genoptog behandlingen uden forudgående symptomer på en overfølsomhedsreaktion (dvs. patienter, der tidligere blev vurderet som værende tolerante over for abacavir).
English: Response rates at 96 weeks were 82% for DTG+ABC/3TC and 75% for DRV/r+ABC/3TC.
Danish: Efter 96 uger var responset 82 % for DTG+ABC/3 TC og 75 % for DRV/r+ABC/3 TC.
English: Using strain NL432 mutations E92Q (fold change 3) and G193E (fold change 3) were selected.
Danish: Ved brug af brug af stamme NL432 blev mutationerne E92Q (FC 3) og G193E (også FC 3) selekteret.
English: The carcinogenic potential of a combination of dolutegravir, abacavir and lamivudine has not been tested.
Danish: Det karcinogene potentiale af en kombination af dolutegravir, abacavir og lamivudin er ikke blevet testet.
English: Hypersensitivity reactions can start at any time during treatment with Triumeq, but are more likely during the first 6 weeks of treatment.
Danish: Du kan få en overfølsomhedsreaktion på et hvilket som helst tidspunkt under behandlingen med Triumeq, men risikoen er størst i de første 6 uger af behandlingen.
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
Danish: Hos patienter med leverinsufficiens, herunder kronisk aktiv hepatitis, ses oftere abnorm leverfunktion i forbindelse med antiretroviral kombinationsbehandling, og disse patienter bør monitoreres i henhold til standardpraksis.
English: In vitro, lamivudine was an inhibitor of OCT1 and OCT2; the clinical consequences are not known.
Danish: In vitro var lamivudin en hæmmer af OCT1 og OCT2; de kliniske konsekvenser er ikke kendt.
English: Mannitol (E421) Microcrystalline cellulose Povidone (K29/32) Sodium starch glycollate Magnesium stearate
Danish: Mannitol (E421) Mikrokrystallinsk cellulose Povidon (K29/32) Natriumstivelsesglycolat Magnesiumstearat
English: Effect of dolutegravir, abacavir and lamivudine on the pharmacokinetics of other medicinal products
Danish: Virkning af dolutegravir, abacavir og lamivudin på farmakokinetikken af andre lægemidler
English: abnormal dreams, depression, anxiety1, nightmare, sleep disorder
Danish: Abnormale drømme, depression, angst, mareridt, søvnforstyrrelser
English: In the case of the Q148-mutation viruses, increasing dolutegravir fold change is seen as the number of secondary mutations increase.
Danish: I tilfælde af virus med Q148-mutation er der set en stigende dolutegravir-FC, efterhånden som antallet af sekundære mutationer stiger.
English: At 96 weeks, virologic suppression in the dolutegravir group (80%) was superior to the DRV/r group (68%), (adjusted treatment difference [DTG-(DRV+RTV)]: 12.4%; 95% CI: [4.7, 20.2]).
Danish: Virologisk suppression i dolutegravir-gruppen (80 %) var superior i forhold til DRV/r-gruppen (68 %) efter 96 uger (justeret behandlingsforskel [DTG-(DRV+RTV)]: 12,4 %; 95 % CI: [4,7, 20,2]).
English: (organic cation transporter inhibition)
Danish: (hæmning af organiske kation transportere)
English: Plasma Cmax and AUC of dolutegravir following administration of Triumeq with a high fat meal were 37% and 48% higher, respectively, than those following administration of Triumeq in the fasted state.
Danish: Plasma-Cmax og -AUC af dolutegravir efter administration af Triumeq sammen med et måltid med højt fedtindhold var henholdsvis 37 % og 48 % højere end efter administration af Triumeq ved fastende tilstand.
English: The geometric mean terminal half-life of intracellular active moiety carbovirtriphosphate (TP) at steady-state is 20.6 hours.
Danish: Den geometriske middelværdi af den terminale halveringstid af den intracellulært aktive del carbovirtriphosphat (CBVTP) ved steady state er 20,6 timer.
English: This recurrence is usually more severe than on initial presentation, and may include life-threatening hypotension and death.
Danish: Denne tilbagevenden er normalt sværere end den initiale reaktion og kan eventuelt inkludere livstruende hypotension og død.
English: Diagnosis of Abacavir Hypersensitivity Reaction Major symptoms associated with ABC HSR are fever (~80%), rash (~70%), gastrointestinal symptoms (>50%) such as nausea, abdominal pain, vomiting, and diarrhoea, generalise malaise, fatigue, and headache (~50%) and other symptoms (~30%) such as respiratory, mucosal, and musculoskeletal symptoms.
Danish: De vigtigste symptomer forbundet med ABC-overfølsomhedsreaktion er feber (~80%), udslæt (~70%), gastrointestinale symptomer (>50%) som f.eks. kvalme, abdominalsmerter, opkastning og diarré, generel utilpashed, træthed og hovedpine (~50%) og andre symptomer (~30%) som f.eks. respiratoriske, slimhinde- og muskuloskeletale symptomer.
English: Additionally, autoinduction of abacavir metabolism or induction of the metabolism of other medicinal products hepatically metabolised has not been observed in humans.
Danish: Desuden er der ikke hos mennesker observeret autoinduktion af metaboliseringen af abacavir eller induktion af metaboliseringen af andre stoffer, som metaboliseres i leveren.
English: The pharmacokinetics of abacavir in patients with end-stage renal disease is similar to patients with normal renal function.
Danish: Farmakokinetikken af abacavir hos patienter med nyresygdom i slutstadiet svarer til farmakokinetikken hos patienter med normal nyrefunktion.
English: There are no data available on the effects of the combination of dolutegravir, abacavir and lamivudine in animals, except a negative in vivo rat micronucleus test which tested the effects of the combination of abacavir and lamivudine.
Danish: Der er ingen tilgængelige data om effekterne af kombinationen af dolutegravir, abacavir og lamivudin hos dyr, bortset fra en negativ mikronukleusanalyse udført in vivo hos rotter, hvor effekterne af kombinationen af abacavir og lamivudin blev undersøgt.
English: The results of an in vivo rat micronucleus test with abacavir and lamivudine in combination were negative.
Danish: Resultaterne af en mikronukleusanalyse udført in vivo hos rotter med abacavir og lamivudin i kombination var negative.
English: Uncommon suicidal ideation or suicide attempt (particularly in patients with a pre-existing history of depression or psychiatric illness)
Danish: Selvmordstanker eller selvmordsforsøg (særligt hos patienter med depression eller psykisk sygdom i anamnesen)
English: ‡ Includes subjects who discontinued due to an adverse event or death at any time point from Day 1 through the Week 48 analysis window if this resulted in no virologic data on treatment during the analysis window.
Danish: ‡ Omfatter personer, der fik seponeret behandlingen på grund af bivirkning eller dødsfald på et hvilket som helst tidspunkt fra dag 1 og gennem hele analysetidsrammen på de 48 uger, hvis dette resulterede i ingen virologiske data på behandlingen inden for analysevinduet.
English: Please refer to section 4.4 for further details on patient management in the event of a suspected HSR to Triumeq.
Danish: 4.4 for nærmere oplysninger om håndtering af patienter i tilfælde af en formodet overfølsomhedsreaktion over for Triumeq.
English: The unbound fraction of dolutegravir in plasma is increased at low levels of serum albumin (<35 g/L) as seen in subjects with moderate hepatic impairment.
Danish: Den ubundne fraktion af dolutegravir i plasma øges ved lave niveauer af serumalbumin (< 35 g/l), som set hos personer med moderat nedsat leverfunktion.
English: GI intolerance in monkeys occurred at 30 times the human mg/kg equivalent dose (based on 50 kg human), and 11 times the human mg/m2 equivalent dose for a total daily clinical dose of 50 mg.
Danish: GI intolerance hos aber forekom ved 30 gange den ækvivalente humane dosis udtrykt i mg/kg (baseret på et menneske på 50 kg) og ved 11 gange den ækvivalente humane dosis udtrykt i mg/m2 for en klinisk dosis på 50 mg.
English: Abacavir and lamivudine triphosphates show significantly less affinity for host cell DNA polymerases.
Danish: Abacavir- og lamivudintriphosphater har signifikant mindre affinitet for værtscelle-DNA-polymeraser.
English: STRIIVING (201147) is a 48-week, randomized, open-label, active controlled, multicenter, noninferiority study in patients without any prior treatment failure, and without any documented resistance to any class.
Danish: STRIIVING (201147) er et 48-ugers randomiseret, åbent, non-inferiort multicenterstudie med aktiv kontrol hos patienter uden forudgående behandlingssvigt og uden dokumenteret resistens over for nogen klasser.
English: If Triumeq is discontinued in patients co-infected with hepatitis B virus, periodic monitoring of both liver function tests and markers of HBV replication is recommended, as withdrawal of lamivudine may result in an acute exacerbation of hepatitis.
Danish: Hvis Triumeq seponeres hos patienter, der er co-inficeret med hepatitis B-virus, anbefales periodisk monitorering af både levertal og markører for HBV-replikation, da seponering af lamivudin kan resultere i en akut forværring af patientens hepatitis.
English: EFV/TDF/FTC = efavirenz 600 mg, tenofovir disoproxil 245 mg, emtricitabine 200 mg in the form of Atripla FDC.
Danish: EFV/TDF/FTC = 600 mg efavirenz, 245 mg tenofovir disoproxil, 200 mg emtricitabin i form af fast-dosis-kombinationen (FDC) Atripla.
English: Key elements included in the educational material to increase understanding and awareness of ABC HSR and expand on the information already included in the SmPC:
Danish: Hovedelementer i uddannelsesmaterialet for at øge forståelsen for og opmærksomheden på ABCoverfølsomhedsreaktion og udvide informationen, som allerede er inkluderet i det godkendte EU produktresumé.
English: hypertriglyceridaemia, hyperglycaemia
Danish: Hypertriglyceridæmi, hyperglykæmi
English: OTHER SPECIAL WARNING(S), IF NECESSARY WARNING!
Danish: EVENTUELLE ANDRE SÆRLIGE ADVARSLER ADVARSEL!
English: HIV-1 RNA <50 copies/mL Treatment Difference*
Danish: Hiv-1-RNA < 50 kopier/ml Behandlingsforskel*
English: In ARIA (ING117172), a randomized, open-label, active-controlled, multicenter, parallel group, noninferiority study; 499 HIV-1 infected ART naïve adult women were randomized 1:1 to receive either; DTG/ABC/3TC FDC 50 mg/600 mg/300 mg; or atazanavir 300 mg plus ritonavir 100 mg plus tenofovir disproxil / emtricitabine 245 mg/200 mg (ATV+RTV+TDF/FTC FDC), all administered once daily.
Danish: I ARIA (ING117172), et randomiseret, åbent, non-inferiort multicenterstudie med aktiv kontrol og parallelle grupper, blev 499 HIV-1-inficerede ART-naive voksne kvinder randomiseret 1:1 til at få enten DTG/ABC/3TC FDC 50 mg/600 mg/300 mg; eller atazanavir 300 mg plus ritonavir 100 mg plus tenofovir disproxil/emtricitabin 245 mg/ 200 mg (ATV + RTV + TDF/FTC FDC), alle administreret én gang dagligt.
English: In contrast, starting passage with mutants with mutation Q148H (fold change 1), a variety of raltegravir associated secondary mutations accumulated with a consequent increase of fold change to values >10.
Danish: Blev passage derimod startet med mutanter, der husede mutation Q148H (FC 1), akkumuleredes en række raltegravir-relaterede sekundære mutationer, der resulterede i en øgning af FC til en værdi > 10.
English: HIV-1 isolates (CRF01_AE, n=12; CRF02_AG, n=12; and Subtype C or CRF_AC, n=13) from 37 untreated patients in Africa and Asia were susceptible to abacavir (IC50 fold changes < 2.5), and lamivudine (IC50 fold changes < 3.0), except for two CRF02_AG isolates with fold changes of 2.9 and 3.4 for abacavir.
Danish: Hiv-1-isolater (CRF01_AE, n = 12, CRF02_AG, n = 12 og undertype C eller CRF_AC, n = 13) fra 37 ubehandlede patienter i Afrika og Asien var følsomme over for abacavir (IC50 < 2,5-gange ændring) og lamivudin (IC50 < 3,0-gange ændring), med undtagelse af to CRF02_AG-isolater med 2,9- og 3,4gange ændring for abacavir.
English: In 100% human serum, the mean fold shift for dolutegravir activity was 75-fold, resulting in protein adjusted IC90 of 0.064 ug/mL.
Danish: Virkning af humant serum I 100 % humant serum var den gennemsnitlige ændring i proteinfoldning en faktor 75, hvilket resulterede i en proteinjusteret IC90-værdi på 0,064 ug/ml.
English: The terminal intracellular half-life of lamivudine-TP was prolonged to 16-19 hours, compared to the plasma lamivudine half-life of 5-7 hours, supporting once daily dosing of ABC and 3TC.
Danish: Den terminale intracellulære halveringstid af lamivudin-TP var forlænget til 16-19 timer, mens halveringstiden af lamivudin i plasma var 5-7 timer, hvilket understøtter dosering af ABC og 3TC én gang daglig.
English: Co-administration of Triumeq and other medicinal products that inhibit UGT1A1, UGT1A3, UGT1A9, CYP3A4, and/or P-gp may therefore increase dolutegravir plasma concentration.
Danish: Samtidig administration af Triumeq og andre lægemidler, der hæmmer UGT1A1, UGT1A3, UGT1A9, CYP3A4 og/eller Pgp, kan derfor øge plasmakoncentrationen af dolutegravir.