FrancophonIA/ELRC3.0 huggingface dataset:
English: 1,216 antiretroviral-therapy naïve patients with plasma HIV-1 RNA > 5,000 copies/ml at baseline were assigned to nevirapine 400 mg once daily, nevirapine 200 mg twice daily, efavirenz 600 mg once daily, or nevirapine (400 mg) and efavirenz (800 mg) once daily, plus stavudine and lamivudine for 48 weeks.
Danish: 1.216 antiretroviralterapi-naive patienter med plasma hiv-1 RNA ved baseline > 5.000 kopier/ml blev i 48 uger allokeret til nevirapin 400 mg én gang daglig, nevirapin 200 mg to gange daglig, efavirenz 600 mg én gang daglig eller nevirapin (400 mg) og efavirenz (800 mg) én gang daglig, plus stavudin og lamivudin.
English: Nevirapine Teva with food and drink
Danish: Brug af Nevirapin Teva sammen med mad og drikke
English: Methadone-maintained patients beginning Nevirapine Teva therapy should be monitored for evidence of withdrawal and methadone dose should be adjusted accordingly.
Danish: Methadonbehandlede patienter, som skal begynde Nevirapin Teva-behandling, bør monitoreres for abstinenssymptomer og efterfølgende have methadondosis justeret afhængigt af disse.
English: Hormonal methods of birth control other than Depot-medroxyprogesterone acetate (DMPA) should not be used as the sole method of contraception in women taking Nevirapine Teva, since nevirapine might lower the plasma concentrations of these medicinal products.
Danish: Hormonel kontraceptiva, bortset fra depot-medroxyprogesteronacetat (DMPA) bør ikke bruges som eneste antikonception af kvinder, som tager Nevirapin Teva, da nevirapin kan sænke plasmakoncentrationen af disse lægemidler.
English: They should be informed that occurrence of symptoms suggestive of hepatitis should lead them to discontinue nevirapine and immediately seek medical evaluation, which should include liver function tests.
Danish: De skal informeres om, at hvis de oplever symptomer, der tyder på hepatitis, skal de straks stoppe med nevirapin og omgående søge lægehjælp som bør omfatte leverfunktionstest.
English: No significant effect on rifabutin and nevirapine mean PK parameters is seen.
Danish: Ingen signifikant virkning på rifabutin og nevirapin gennemsnitlige farmakokinetiske (PK) parametre er observeret.
English: Women have a three fold higher risk than men for symptomatic, often rash-associated, hepatic events (5.8 % versus 2.2 %), and treatment-naïve patients of either gender with detectable HIV-1 RNA in plasma with higher CD4 counts at initiation of nevirapine therapy are at higher risk for symptomatic hepatic events with nevirapine.
Danish: Kvinder har 3 gange større risiko end mænd for symptomatiske, ofte udslætassocierede leverpåvirkninger (5,8 % versus 2,2 %), og behandlingsnaive patienter af begge køn med detekterbart hiv-1-RNA i plasma og med et højere CD4-celletal ved behandlingsstart af nevirapin har en større risiko for symptomatisk leverpåvirkning under nevirapinbehandling.
English: Ribavirin does not inhibit cytochrome P450 enzymes, and there is no evidence from toxicity studies that ribavirin induces liver enzymes.
Danish: Ribavirin hæmmer ikke CYPenzymer, og fra toksicitetesstudier er der ingen tegn på, at ribavirin inducerer leverenzymer.
English: This increased risk for toxicity based on CD4 count thresholds has not been detected in patients with undetectable (i.e. < 50 copies/ml) plasma viral load.
Danish: Denne øgede risiko for toksicitet baseret på CD4-celletalniveauer, er ikke set hos patienter med en udetekterbar viral belastning i plasma - dvs. <50 kopier/ml.
English: Renal dysfunction: The single-dose pharmacokinetics of nevirapine has been compared in 23 patients with either mild (50 ≤ CLcr < 80 ml/min), moderate (30 ≤ CLcr < 50 ml/min) or severe renal dysfunction (CLcr < 30 ml/min), renal impairment or end-stage renal disease (ESRD) requiring dialysis, and 8 patients with normal renal function (CLcr > 80 ml/min).
Danish: Nedsat nyrefunktion: Enkeltdosis-farmakokinetikken af nevirapin er blevet sammenlignet med 23 patienter med enten mild (50 ≤ CLcr < 80 ml/min), moderat (30 ≤ CLcr < 50 ml/min) eller svært nedsat nyrefunktion (CLcr < 30 ml/min), dialysekrævende end-stage nyresygdom (ESRD), og 8 patienter med normal nyrefunktion (CLcr > 80 ml/min).
English: There are toxicities that require interruption of Nevirapine Teva therapy (see section 4.4).
Danish: Der er bivirkninger, som kræver afbrydelse af Nevirapin-behandling (se pkt.
English: In a mass balance/excretion study in eight healthy male volunteers dosed to steady state with nevirapine 200 mg given twice daily followed by a single 50 mg dose of 14C-nevirapine, approximately 91.4 ± 10.5 % of the radiolabelled dose was recovered, with urine (81.3 ± 11.1 %) representing the primary route of excretion compared to faeces (10.1 ± 1.5%).
Danish: I et massebalance/ ekskretionsstudie med 8 raske, frivillige, mandlige forsøgspersoner, som blev behandlet indtil steady state med nevirapin 200 mg 2 gange daglig efterfulgt af en enkelt dosis på 50 mg af 14Cnevirapin blev tilnærmelsesvis 91,4±10,5 % af den radioaktivt mærkede dosis genfundet: I urinen (81,3±11,1 %), hvilket repræsenterer den primære ekskretionsvej sammenlignet med fæces (10,1±1,5 %).
English: The nevirapine twice daily regimen and the efavirenz regimen were not significantly different (p= 0.091) in terms of efficacy as measured by treatment failure, or any component of treatment failure including virological failure.
Danish: Der sås ikke signifikant forskel på virkningen i ”nevirapin 2 gange daglig”-regimegruppen og efavirenz-regimegruppen (p = 0,091) bedømt ud fra behandlingssvigt, eller tilfælde af behandlingssvigt, herunder virologisk svigt.
English: The following events have also been reported when nevirapine has been used in combination with other antiretroviral agents: - decreased numbers of red blood cells or platelets - inflammation of the pancreas - decrease in or abnormal skin sensations.
Danish: Følgende tilfælde har også været rapporteret, når nevirapin er blevet taget i kombination med andre retrovirale midler: - fald i antal røde blodlegemer eller i blodplader - betændelse i bugspytkirtlen - nedsat eller abnorm følsomhed i huden
English: What you need to know before you take Nevirapine Teva Do not take Nevirapine Teva
Danish: Det skal du vide, før du begynder at tage Nevirapin Teva Tag ikke Nevirapin Teva
English: Hepatic dysfunction: A steady state study comparing 46 patients with mild (n=17: Ishak Score 1-2), moderate (n=20; Ishak Score 3-4), or severe (n=9; Ishak Score 5-6, Child-Pugh A in 8 pts., for 1 Child-Pugh score not applicable) liver fibrosis as a measure of hepatic impairment was conducted.
Danish: Nedsat leverfunktion: Et steady state-studie blev udført, hvilket sammenlignede 46 patienter med mild (n=17; Ishak Score 1-2), moderat (n=20; Ishak Score 3-4), eller alvorlig (n=9; Ishak Score 5-6, Child-Pugh A i 8 patienter, score for 1 Child-Pugh er ikke tilgængelig) leverfibrose som målestok for hepatisk dysfunktion.
English: If you are taking or are prescribed rifampicin to treat tuberculosis please inform your doctor before taking this medicine with Nevirapine Teva.
Danish: Hvis du tager eller får ordineret rifampicin til behandling af tuberkulose, skal du tale med din læge, før du tager Nevirapin Teva.
English: Your doctor will carefully monitor the effect of Nevirapine Teva and any of these medicines if you are taking them together.
Danish: Din læge vil nøje kontrollere virkningen af Nevirapin Teva og den nævnte medicin ovenfor, hvis du bliver behandlet med flere slags medicin på samme tid.
English: Of the patients with grade 3 or 4 liver-associated laboratory toxicity, the proportions coinfected with hepatitis B or hepatitis C virus were 6.7% and 20.0% in the nevirapine twice daily group, 5.6% and 11.1% in the efavirenz group.
Danish: I gruppen med grad 3 eller 4 leverrelateret laboratorietoksicitet var andelen, som samtidig havde hepatitis B henholdsvis hepatitis C-virus, 6,7 % og 20,0 % i ”nevirapin 2 gange daglig”-gruppen, og 5,6 % og 11,1 % i efavirenzgruppen.
English: Coadministration of telaprevir and medicinal products that induce CYP3A and/or P-gp may decrease telaprevir plasma concentrations.
Danish: Samtidig administration af telaprevir og CYP3A- og/eller P-gp-inducere kan nedsætte telaprevirplasmakoncentrationen.
English: Peak plasma nevirapine concentrations of 2 ± 0.4 μg/ml (7.5 μM) were attained by 4 hours following a single 200 mg dose.
Danish: Peakplasmakoncentration for nevirapin på 2 ± 0,4 µg/ml (7,5 µM) opnås efter 4 timer efter en enkelt dosis på 200 mg.
English: Fosamprenavir 1,400 mg BID
Danish: Fosamprenavir 1.400 mg 2 gange daglig
English: Dose adjustment of Nevirapine Teva is not required when co-administered with lopinavir.
Danish: Dosisjustering for Nevirapin Teva er ikke påkrævet når der coadministreres med lopinavir.
English: For children under 16 years of age who weigh less than 50 kg or whose body surface area is below 1.25 m2 other nevirapine containing oral formulations are available and should be used if appropriate.
Danish: Til børn under 16 år, som vejer mindre end 50 kg eller hvis kropsareal er under 1,25 m2, findes nevirapin i flydende form, som kan anvendes, hvis det er hensigtsmæssigt.
English: Patients developing signs or symptoms of hepatitis, severe skin reaction or hypersensitivity reactions must discontinue nevirapine and seek medical evaluation immediately.
Danish: Patienter, som udvikler tegn eller symptomer på hepatitis, svært hududslæt eller overfølsomhedsreaktioner, skal stoppe nevirapinbehandling og søge lægehjælp omgående.
English: Significantly fewer patients in the abacavir group (9 patients, or 6%) than in the nevirapine group (26 patients, or 17%) or the efavirenz group (27 patients, or 17%) discontinued the medicinal product because of adverse events.
Danish: Signifikant færre patienter i abacavirgruppen stoppede behandlingen på grund af uønskede hændelser (9 patienter eller 6 %) end i nevirapingruppen (26 patienter eller 17 %) eller i efavirenzgruppen (27 patienter eller 17 %).
English: Increased ASAT or ALAT levels ≥ 2.5 ULN and/or co-infection with hepatitis B and/or C at the start of antiretroviral therapy is associated with greater risk of hepatic adverse reactions during antiretroviral therapy in general, including nevirapine containing regimens.
Danish: Generelt er stigende ASAT- eller ALAT-niveauer ≥ 2,5 ULN og/eller samtidig infektion med hepatitis B og/eller C ved starten af antiretroviral behandling forbundet med større risiko for leverbivirkninger under antiretroviral behandling inklusive regimer indeholdende nevirapin.
English: Nevirapine must not be readministered to patients who have required permanent discontinuation for clinical hepatitis due to nevirapine.
Danish: Nevirapin må ikke readministreres til patienter, hvor en seponering af nevirapin har været begrundet i klinisk hepatitis.
English: Norethindrone (NET) 1.0 mg QD
Danish: Norethindron (NET) 1,0 mg 4 gange daglig
English: The dose of Nevirapine Teva may need adjusting.
Danish: Nevirapin Teva-dosering skal muligvis justeres.
English: The 14-day “lead-in” period has been shown to lower the risk of skin rash.
Danish: Det har vist sig, at en 14-dages optrapningsperiode mindsker risikoen for hududslæt.
English: ANTI-INFECTIVES Antiretrovirals
Danish: ANTI-INFEKTIVA Antivirale lægemidler
English: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Danish: Nogle patienter, der får flere antiretrovirale lægemidler på samme tid, kan udvikle en knoglesygdom, som kaldes knoglenekrose (knoglevævet dør på grund af blodmangel til knoglerne).
English: Therefore, patients who receive nevirapine and zidovudine concomitantly and especially paediatric patients and patients who receive higher zidovudine doses or patients with poor bone marrow reserve, in particular those with advanced HIV disease, have an increased risk of granulocytopenia.
Danish: Patienter i samtidig behandling med nevirapin og zidovudin og især pædiatriske patienter, patienter, som får højere doser af zidovudin, samt patienter med ringe knoglemarvsreserve, specielt patienter med fremskreden hiv-sygdom, har derfor øget risiko for granulocytopeni.
English: Nevirapine has been shown to be an inducer of hepatic cytochrome P450 metabolic enzymes.
Danish: Nevirapin har vist sig at inducere leverens cytokrome P450-metaboliske enzymer.
English: Package leaflet: Information for the patient Nevirapine Teva 200 mg tablets nevirapine
Danish: Indlægsseddel: Information til patienten Nevirapin Teva 200 mg tabletter nevirapin
English: CONTRACEPTIVES
Danish: KONTRACEPTIVA
English: If you develop severe liver, skin or hypersensitivity reactions whilst taking Nevirapine Teva, NEVER TAKE Nevirapine Teva again without referring to your doctor.
Danish: Hvis du får alvorlige lever-, hud- eller overfølsomhedsreaktioner under behandling med Nevirapin Teva, må du ALDRIG tage Nevirapin Teva igen, medmindre det er ordineret af lægen.
English: Nevirapine must not be restarted following severe hepatic, skin or hypersensitivity reactions (see section 4.3).
Danish: Behandling med nevirapin må ikke genstartes efter svær lever-, hud- eller overfølsomhedsreaktioner (se pkt.
English: Nevirapine Teva contains lactose
Danish: Nevirapin Teva indeholder lactose
English: Investigations Common liver function tests abnormal (alanine aminotransferase increased; transaminases increased; aspartate aminotransferase increased; gamma-glutamyltransferase increased; hepatic enzyme increased; hypertransaminasaemia) Uncommon blood phosphorus decreased; blood pressure increased
Danish: Leverfunktionstests uden for normalområdet (forhøjet alanin aminotransferase; forhøjede transaminaser; forhøjet aspartat aminotransferase; forhøjet gammaglutamyltransferase; forhøjet hepatisk enzym; hypertransaminasaemi)
English: Prednisone should not be used to treat a rash related to Nevirapine Teva.
Danish: Prednison bør ikke anvendes til behandling af udslæt forårsaget af Nevirapin Teva.
English: Contents of the pack and other information What Nevirapine Teva contains
Danish: Pakningsstørrelser og yderligere oplysninger Nevirapin Teva indeholder:
English: The study randomly assigned 460 adults who were taking two nucleoside reverse-transcriptase inhibitors and at least one PI and whose plasma HIV-1 RNA levels had been less than 200 c/ml for at least the previous six months to switch from the PI to nevirapine (155 patients), efavirenz (156), or abacavir (149).
Danish: I studiet blev 460 voksne, som var i behandling med 2 nukleosid-revers-transkriptasehæmmere og mindst en PI, og hvis plasma-hiv-1 RNA-niveau havde været lavere end 200 c/ml i mindst 6 måneder, skiftet til behandling fra proteasehæmmeren enten til nevirapin (155 patienter), til efavirenz (156 patienter) eller til abacavir (149 patienter).
English: It is not recommended to coadminister efavirenz and Nevirapine Teva (see section 4.4), because of additive toxicity and no benefit in terms of efficacy over either NNRTI alone (for results of 2NN study, see section 5.1).
Danish: Co-administration af efavirenz og Nevirapin Teva anbefales ikke på grund af additiv toksicitet og ingen fordel med hensyn til virkning i forhold til det enkelte NNRTI alene (for resultaterne fra 2NN-studiet, se pkt.
English: Dosing of nevirapine at 150 mg/m2 BID (after a two-week lead in at 150 mg/m2 QD) produced geometric mean or mean trough nevirapine concentrations between 4-6 μg/ml (as targeted from adult data).
Danish: Dosering af nevirapin med 150 mg/m² to gange dagligt (efter en to ugers indkøringsperiode med 150 mg/m² en gang dagligt) gav geometriske middelværdier eller middelværdi af trough nevirapinkoncentrationer på 4-6 μg/ml (som voksendata).
English: Itraconazole Cmin ↓ 0.13 Itraconazole Cmax ↓ 0.62
Danish: Itraconazol Cmin ↓ 0,13 Itraconazol Cmax ↓ 0,62
English: Do not take Nevirapine Teva after an exposure to HIV unless you have been diagnosed with HIV and instructed to do so by your doctor.
Danish: Tag ikke Nevirapin Teva hvis du er blevet udsat for hiv, med mindre du er blevet diagnosticeret med hiv, og lægen har foreskrevet det. Nevirapin Teva kan ikke helbrede en hiv-infektion.
English: If co-administered with Nevirapine Teva, an adjustment in the telaprevir dose should be considered.
Danish: Ved administration sammen med Nevirapin Teva bør justering af telaprevirdosis overvejes.
English: If you forget to take Nevirapine Teva
Danish: Hvis du har glemt at tage Nevirapin Teva
English: Depotmedroxyprogesterone acetate (DMPA) 150 mg every 3 months
Danish: Depotmedroxyprogesteronacetat (DMPA) 150 mg hver 3. måned
English: These have included cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity reactions characterised by rash, constitutional findings and visceral involvement.
Danish: Disse tilfælde omfatter Stevens-Johnsons syndrom, toksisk epidermal nekrolyse og overfølsomhedsreaktioner kendetegnet ved udslæt, konstitutionelle symptomer og andre organpåvirkninger.
English: Appropriate doses for hormonal contraceptives (oral or other forms of application) other than DMPA in combination with nevirapine have not been established with respect to safety and efficacy.
Danish: I forhold til sikkerhed og virkning er der ikke fastlagt egnede doser for hormonel antikonception (oral eller anden administration) ud over DMPA sammen med nevirapin.
English: Nevirapine Teva should only be used with at least two other antiretroviral agents (see section 5.1).
Danish: Nevirapin Teva bør kun anvendes sammen med mindst to andre antiretrovirale lægemidler (se pkt.
English: DMPA AUC ↔ DMPA Cmin ↔ DMPA Cmax ↔
Danish: DMPA AUC ↔ DMPA Cmin ↔ DMPA Cmax ↔ Nevirapin AUC ↑ 1,20 Nevirapin Cmax ↑ 1,20
English: Most of the experience with nevirapine is in combination with nucleoside reverse transcriptase inhibitors (NRTIs).
Danish: Hovedparten af erfaringen med nevirapin er i kombinationen med nukleosid reverse transkriptasehæmmere.
English: Patients have experienced oedema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonary infiltrates, rash, vertigo, vomiting, increase in transaminases and weight decrease.
Danish: Patienter har oplevet ødemer, erythema nodosum, træthed, feber, hovedpine, søvnmangel, kvalme, lungeinfiltrater, udslæt, svimmelhed, opkastninger, stigning i transsaminaser og vægttab.
English: If you stop taking Nevirapine Teva
Danish: Hvis du holder op med at tage Nevirapin Teva
English: Oral hormonal contraceptives should not be used as the sole method of contraception in women taking Nevirapine Teva (see section 4.4).
Danish: Oral hormonel antikonception bør ikke anvendes, som den eneste svangerskabsforebyggende metode hos kvinder, der behandles med Nevirapin Teva (se pkt.
English: Talk to your doctor or pharmacist before taking Nevirapine Teva During the first 18 weeks of treatment with Nevirapine Teva it is very important that you and your doctor watch out for signs of liver or skin reactions.
Danish: I de første 18 uger, hvor du er i behandling med Nevirapin Teva, er det meget vigtigt, at du og din læge holder øje med, om der er tegn på leverskader eller hududslæt.
English: You must take the dose of Nevirapine Teva as prescribed by your doctor.
Danish: Du bør tage den dosis Nevirapin Teva, som er foreskrevet af lægen.
English: The following patients are at increased risk of developing liver problems: - women - infected with hepatitis B or C - abnormal liver function tests - treatment-naïve patients with higher CD4 cell counts at the start of Nevirapine Teva therapy
Danish: Følgende patientgrupper har en forhøjet risiko for at udvikle leverskader: - kvinder - patienter, der er smittet med hepatitis B eller hepatitis C - patienter med unormale leverfunktionsværdier - tidligere ubehandlede patienter, der har forhøjede CD4-celletal ved starten af behandling med
English: Nevirapine Teva tablets contain lactose (milk sugar).
Danish: Nevirapin Teva tabletter indeholder lactose.
English: In a 200 mg nevirapine single dose pharmacokinetic study of HIV-negative patients with mild and moderate hepatic impairment (Child-Pugh A, n=6; Child-Pugh B, n=4), a significant increase in the AUC of nevirapine was observed in one Child-Pugh B patient with ascites suggesting that patients with worsening hepatic function and ascites may be at risk of accumulating nevirapine in the systemic circulation.
Danish: I et 200 mg nevirapin enkeltdosis farmakokinetisk studie af hiv-negative patienter med mild til moderat hepatisk dysfunktion (Child-Pugh A, n=6; Child-Pugh B, n=4), blev der observeret en signifikant forøgelse af nevirapin-AUC hos en Child-Pugh B-patient med ascites.
English: The frequency category was estimated from a statistical calculation based on the total number of patients exposed to nevirapine in randomised controlled clinical studies (n= 2,718).
Danish: Hyppigheden er estimeret statistisk ud fra det antal patienter, som fik nevirapin behandling i randomiserede, kontrollerede kliniske studier (n
English: Patients experiencing rash during the 14-day lead-in period of 200 mg/day should not have their Nevirapine Teva dose increased until the rash has resolved.
Danish: Overvejelser i forbindelse med fastsættelse af dosis Patienter, som udvikler udslæt i optrapningsperioden på 14 dage med 200 mg/dag, bør ikke øge dosis af Nevirapin Teva, før udslættet er forsvundet.
English: Mild isolated neutropenia and hyperlactataemia was observed, which spontaneously disappeared within one week without any clinical complications.
Danish: Det forsvandt spontant inden for en uge uden kliniske komplikationer.
English: Lactose: Nevirapine Teva tablets contain 336 mg of lactose per maximum recommended daily dose.
Danish: Lactose: Ved den maksimale, anbefalede daglige dosis af Nevirapin Teva tabletter indtages 336 mg lactose.
English: Coadministration with herbal preparations containing St John's wort (Hypericum perforatum) due to the risk of decreased plasma concentrations and reduced clinical effects of nevirapine (see section 4.5).
Danish: Samtidig behandling med naturlægemidler indeholdende perikon (Hypericum perforatum) pga. risiko for nedsat plasmakoncentration og reduceret klinisk effekt af nevirapin (Se pkt.
English: If you experience symptoms suggesting a damage of the liver, such as - loss of appetite, - feeling sick (nausea), - vomiting, - yellow skin (jaundice), - abdominal pain you should discontinue taking Nevirapine Teva and must contact your doctor immediately.
Danish: Hvis du får symptomer, som kan tyde på, at leveren har taget skade såsom - appetitløshed - kvalme - opkastning - gulsot (huden bliver gul) - mavesmerter skal du stoppe med at tage Nevirapin Teva og straks kontakte lægen.
English: Serum levels of nevirapine can be reduced by concomitant use of the herbal preparation St. John's Wort (Hypericum perforatum).
Danish: Serumniveauet af nevirapin kan være reduceret ved samtidig brug af naturlægemidlet, perikon (Hypericum perforatum).
English: The most frequently reported adverse reactions related to nevirapine therapy, across all clinical studies, were rash, allergic reactions, hepatitis, abnormal liver function tests, nausea, vomiting, diarrhoea, abdominal pain, fatigue, fever, headache and myalgia.
Danish: De hyppigst rapporterede bivirkninger relateret til nevirapinbehandling, på tværs af alle kliniske studier, var udslæt, allergiske reaktioner, hepatitis, leverfunktionstests uden for normalområdet, kvalme, opkastninger, diarré, abdominalsmerter, træthed, feber, hovedpine og myalgi.
English: Nevirapine concentrations not measured, no effect is expected.
Danish: Nevirapin-koncentrationer er ikke blevet målt.
English: If you notice that you have missed a dose within 8 hours of when it was due, take the missed dose as soon as possible.
Danish: Hvis du inden for 8 timer opdager, at du har glemt en dosis, så tag den glemte dosis straks.
English: Nevirapine AUC ↓ 0.42
Danish: Nevirapin AUC ↓ 0,42