FrancophonIA/ELRC3.0 huggingface dataset:
English: • Concomitant use of other anti-VEGF (vascular endothelial growth factor) There is no data available on the concomitant use of Eylea with other anti-VEGF medicinal products (systemic or ocular).
Croatian: • Istodobna primjena ostalih anti-VEGF (vaskularni endotelni faktor rasta) lijekova Nema dostupnih podataka o istodobnoj primjeni lijeka Eylea s drugim anti-VEGF lijekovima (sistemskim ili okularnim).
English: These new blood vessels can cause the leak of blood components into the eye and eventual damage to tissues in the eye responsible for vision.
Croatian: Te nove krvne žile propusne su za sastavne dijelove krvi koji ulaze u oko i eventualno oštećenje očnog tkiva zaduženog za vid.
English: Active Control (laser)/Eylea 2mgE)
Croatian: Aktivna kontrola (laser) / Eylea 2 mg E)
English: The following is a list of the side effects reported to be possibly related to the injection procedure or to the medicine.
Croatian: Sljedeći popis sadrži nuspojave zabilježene kao moguće povezane s postupkom davanja injekcije ili lijekom.
English: At week 24 these proportions were 80% and 67%, respectively.
Croatian: U 24. tjednu ti su udjeli bili 80%, odnosno 67%.
English: Therefore, in case of overdose, intraocular pressure should be monitored and if deemed necessary by the treating physician, adequate treatment should be initiated.
Croatian: Stoga, u slučaju predoziranja treba pratiti intraokularni tlak te ako nadležni liječnik procijeni da je to potrebno, započeti odgovarajuće liječenje.
English: • Eylea should not be used in pregnancy unless the potential benefit outweighs the potential risk to the foetus (see section 4.6).
Croatian: • Eylea se ne smije primjenjivati u trudnoći osim ako moguća korist nadmašuje mogući rizik za plod (vidjeti dio 4.6.).
English: Weighted differenceA,B,E) (95% CI)
Croatian: Ponderirana razlikaA,B,E) (95% CI)
English: Within each frequency grouping, adverse drug reactions are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti, nuspojave su prikazane slijedom prema sve manjoj ozbiljnosti.
English: Bayer AG Müllerstraße 178 13353 Berlin Germany
Croatian: Bayer AG Müllerstraße 178 13353 Berlin Njemačka
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 November 2012
Croatian: Datum prvog odobrenja: 22. studeni 2012.
English: Immediately following the intravitreal injection, patients should be monitored for elevation in intraocular pressure.
Croatian: Neposredno nakon intravitrealne injekcije bolesnike treba nadzirati zbog povišenja intraokularnog tlaka.
English: If you are pregnant or planning to become pregnant, discuss this with your doctor before treatment with Eylea.
Croatian: Ako ste trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije liječenja lijekom Eylea.
English: Pharmacotherapeutic group: Ophthalmologicals / Antineovascularisation agents ATC code: S01LA05
Croatian: Farmakoterapijska skupina: Oftalmici / Lijekovi za liječenje neovaskularizacije ATK oznaka: S01LA05
English: The mean maximum plasma concentration of free aflibercept is approximately 50 to 500 times below the aflibercept concentration required to inhibit the biologic activity of systemic VEGF by 50% in animal models, in which blood pressure changes were observed after circulating levels of free aflibercept attained approximately 10 microgram/ml and returned to baseline when levels fell below approximately 1 microgram/ml.
Croatian: Srednje vrijednosti najveće koncentracije slobodnog aflibercepta u plazmi približno su 50 do 500 puta niže od koncentracije aflibercepta potrebne da inhibira biološku aktivnost sistemskog VEGF-a za 50% na životinjskim modelima, u kojih su bile opažene promjene krvnog tlaka nakon što su razine slobodnog aflibercepta u krvotoku postigle vrijednost od približno 10 mikrograma/ml i vratile se na početne vrijednosti nakon što su razine pale ispod približno 1 mikrogram/ml.
English: If there are bubbles, gently tap the syringe with your finger until the bubbles rise to the top.
Croatian: Ako su prisutni mjehurići, nježno prstom kucnite po štrcaljki tako da se mjehurići podignu prema vrhu.
English: Beginning at week 24, patients meeting a pre-specified threshold of vision loss were eligible to receive additional treatment: patients in the Eylea groups could receive laser and patients in the control group could receive Eylea.
Croatian: Počevši od 24. tjedna, bolesnici koji su zadovoljili prethodno određeni prag za gubitak vida bili su pogodni za primanje dodatnog liječenja: bolesnici u skupinama koje su primale lijek Eylea mogli su dobiti lasersko liječenje, a bolesnici u kontrolnoj skupini mogli su dobiti lijek Eylea.
English: In the laser group 67 patients received rescue treatment with Eylea beginning at week 24 (Active Control/ Eylea 2mg group), which resulted in improvement of visual acuity by about 5 letters from week 24 to 52.
Croatian: U skupini s laserom 67 bolesnika primilo je spasonosno liječenje lijekom Eylea početkom 24. tjedna (aktivna kontrola/skupina s lijekom Eylea 2 mg), što je rezultiralo poboljšanjem oštrine vida za otprilike 5 slova od 24. do 52. tjedna.
English: As this is a therapeutic protein, there is a potential for immunogenicity with Eylea (see section 4.8).
Croatian: Budući da se radi o terapijskom proteinu, postoji mogućnost imunogenosti lijeka Eylea (vidjeti dio 4.8).
English: Although the systemic exposure after ocular administration is very low, Eylea should not be used during pregnancy unless the potential benefit outweighs the potential risk to the foetus.
Croatian: Iako je sistemska izloženost nakon primjene u oko vrlo niska, Eylea se ne smije primjenjivati tijekom trudnoće osim ako je moguća korist veća od mogućeg rizika za plod.
English: Overdosing with increased injection volume may increase intraocular pressure.
Croatian: Predoziranje većim volumenom injekcije može povećati intraokularni tlak.
English: Consult your doctor before stopping the treatment.
Croatian: Potražite savjet liječnika prije prestanka liječenja.
English: In general, adequate anaesthesia and asepsis, including topical broad spectrum microbicide (e.g. povidone iodine applied to the periocular skin, eyelid and ocular surface), have to be ensured.
Croatian: Općenito je potrebno osigurati odgovarajuću anesteziju i asepsu, uključujući topikalni mikrobicid širokog spektra (npr. povidon, jodirani primijenjen na kožu periokularno, vjeđe i površinu oka).
English: - There is no experience of using Eylea in pregnant women.
Croatian: - Nema iskustava s primjenom lijeka Eylea u trudnica.
English: Aflibercept is slowly absorbed from the eye into the systemic circulation after intravitreal administration and is predominately observed in the systemic circulation as an inactive, stable complex with VEGF; however only “free aflibercept” is able to bind endogenous VEGF.
Croatian: Aflibercept se nakon intravitrealne primjene polako apsorbira iz oka u sistemski krvotok i u sistemskom se krvotoku pretežno nalazi kao inaktivan, stabilni kompleks s VEGF-om; međutim, samo se “slobodni aflibercept” može vezati za endogeni VEGF.
English: Ask your doctor for advice before starting Eylea treatment.
Croatian: Obratite se svom liječniku za savjet prije početka liječenja lijekom Eylea.
English: (95% CI) p-value p<0.0001
Croatian: (95% CI) p-vrijednost p < 0,0001
English: Eylea is administered directly into the vitreous to exert local effects in the eye.
Croatian: Eylea se primjenjuje izravno u staklovinu kako bi mogla djelovati lokalno u oku.
English: As with other intravitreal anti-VEGF treatments for AMD, CRVO, BRVO, DME and myopic CNV the following also applies:
Croatian: Kao i za ostale anti-VEGF lijekove za intravitrealnu primjenu za AMD, CRVO, BRVO, DME i miopijski CNV vrijedi sljedeće:
English: • Female patients of childbearing potential have to use effective contraception and pregnant women should not use Eylea
Croatian: • Žene reproduktivne dobi moraju koristiti učinkovitu kontracepciju i trudnice ne smiju koristiti lijek Eylea
English: After opening the vial, proceed under aseptic conditions.
Croatian: Nakon otvaranja bočice, postupak treba nastaviti u aseptičkim uvjetima.
English: An effect of aflibercept on intrauterine development was shown in embryo-foetal development studies in pregnant rabbits with intravenous (3 to 60 mg/kg) as well as subcutaneous (0.1 to 1 mg/kg) administration.
Croatian: Učinak aflibercepta na intrauterini razvoj pokazan je u ispitivanjima utjecaja na embriofetalni razvoj u skotnih ženki kunića kod intravenske (3 do 60 mg/kg) kao i supkutane (0,1 do 1 mg/kg) primjene.
English: In the VIVIDDME and VISTADME studies, 36 (9%) and 197 (43%) patients received prior anti-VEGF therapy, respectively, with a 3-month or longer washout period.
Croatian: U ispitivanjima VIVIDDME i VISTADME, 36 (9%) odnosno 197 (43%) bolesnika prethodno je primalo anti-VEGF terapiju, uz razdoblje ispiranja lijeka iz organizma od 3 mjeseca ili dulje.
English: The injection volume of 0.05 ml is then delivered; a different scleral site should be used for subsequent injections.
Croatian: Potom se ubrizgava volumen injekcije od 0,05 ml; sljedeću injekciju treba primijeniti na drugo mjesto na bjeloočnici.
English: Eylea has been shown to stop the growth of new abnormal blood vessels in the eye which often leak fluid or bleed.
Croatian: Pokazalo se da lijek Eylea zaustavlja rast novih abnormalnih krvnih žila u oku, koje često propuštaju tekućinu ili krv.
English: After 6 consecutive monthly injections, patients received treatment only if they met pre-specified retreatment criteria, except for patients in the control group in the GALILEO study who continued to receive sham (control to control) until week 52.
Croatian: Nakon 6 uzastopnih mjesečnih injekcija, bolesnici su primili liječenje samo ako su zadovoljili unaprijed definirane kriterije za ponavljanje liječenja, osim bolesnika u kontrolnoj skupini u ispitivanju GALILEO koji su nastavili primati placebo (kontrola kontrole) do 52. tjedna.
English: Eylea 2Q8 E) (Eylea 2 mg every 8 weeks following 3 initial monthly doses) (N = 607)
Croatian: Eylea 2Q8 E) (Eylea 2 mg svakih 8 tjedana nakon 3 početne mjesečne doze) (N = 607)
English: Aflibercept is a recombinant fusion protein consisting of portions of human VEGF receptor 1 and 2 extracellular domains fused to the Fc portion of human IgG1.
Croatian: Aflibercept je rekombinantni fuzijski protein koji se sastoji od dijelova izvanstaničnih domena 1 i 2 ljudskog VEGF receptora spojenih na Fc dio ljudskog IgG1.
English: Always discuss any suspected side effects with your doctor.
Croatian: Uvijek obavijestite svog liječnika o svakoj sumnji na nuspojavu.
English: The schedule for monitoring should be determined by the treating physician.
Croatian: Raspored kontrolnih pregleda treba odrediti nadležni liječnik.
English: Intravitreal use.
Croatian: Intravitrealna primjena.
English: Manufacturer Bayer AG Müllerstraße 178 13353 Berlin Germany
Croatian: Proizvođač Bayer AG Müllerstraße 178 13353 Berlin Njemačka
English: Other medicines and Eylea Tell your doctor if you are using, have recently used or might use any other medicines.
Croatian: Obavijestite svog liječnika ako uzimate ili ste nedavno uzimali ili biste mogli uzimati bilo koje druge lijekove.
English: F)
Croatian: G)
English: Pharmacokinetic analysis of patients in the VIEW2 study, of which 40% had renal impairment (24% mild, 15% moderate, and 1% severe), revealed no differences with respect to plasma concentrations of active drug after intravitreal administration every 4 or 8 weeks.
Croatian: Farmakokinetička analiza u bolesnika u ispitivanju VIEW2, od kojih je 40% imalo oštećenje funkcije bubrega (24% blago, 15% umjereno i 1% teško), pokazala je da nema razlika s obzirom na koncentracije djelatnog lijeka u plazmi nakon intravitrealne primjene svakih 4 ili 8 tjedana.
English: Treatment effects in the subgroup of patients who had previously been treated with a VEGF inhibitor were similar to those seen in patients who were VEGF inhibitor naïve.
Croatian: Učinci liječenja u podskupinama bolesnika koji su prethodno bili liječeni inhibitorom VEGF-a bili su slični onima opaženima u bolesnika koji nikad nisu primali inhibitor VEGF-a.
English: Eylea is indicated for adults for the treatment of
Croatian: Lijek Eylea je indiciran u odraslih osoba za liječenje
English: In all cases, both the intraocular pressure and the perfusion of the optic nerve head must therefore be monitored and managed appropriately.
Croatian: Stoga je u svim slučajevima potrebno pratiti i intraokularni tlak i perfuziju glave optičkog živca i primjereno ih liječiti.
English: In each study, patients were randomly assigned in a 1:1:1:1 ratio to 1 of 4 dosing regimens:
Croatian: U svakom od ispitivanja, bolesnici su bili randomizirani u omjeru 1:1:1:1 u skupine koje su primale 1 od 4 sljedeća režima doziranja:
English: This decrease from baseline in CRT was maintained to the end of each study, week 100 in COPERNICUS, week 76 in GALILEO, and week 52 in VIBRANT.
Croatian: To smanjenje od početne vrijednosti CRT-a zadržano je do kraja svakog ispitivanja, 100. tjedna u ispitivanju COPERNICUS, 76. tjedna u ispitivanju GALILEO te 52. tjedna u ispitivanju VIBRANT.
English: D) From week 24 on the treatment interval in the Eylea treatment group was extended for all subjects from 4
Croatian: D) Od 24. tjedna nadalje interval liječenja u skupini liječenoj lijekom Eylea produljen je za sve ispitanike s 4
English: Effects in non-clinical studies on repeated dose toxicity were observed only at systemic exposures considered substantially in excess of the maximum human exposure after intravitreal administration at the intended clinical dose indicating little relevance to clinical use.
Croatian: U nekliničkim ispitivanjima toksičnosti ponovljene doze opaženi su učinci pri sistemskoj izloženosti koja se smatra znatno većom od najveće izloženosti ljudi nakon intravitrealne primjene u planiranoj kliničkoj dozi, čime se pokazalo da to nema važnosti u kliničkoj primjeni.
English: The maximal improvement in visual acuity was achieved at month 3 with subsequent stabilisation of visual acuity and CRT until month 6.
Croatian: Maksimalno poboljšanje oštrine vida postignuto je nakon 3 mjeseca s kasnijom stabilizacijom oštrine vida i CRT-a do 6. mjeseca.
English: There is only limited experience in the treatment of - patients with DME due to type I diabetes.
Croatian: Postoji samo ograničeno iskustvo s liječenjem - bolesnika s DME-om zbog šećerne bolesti tipa
English: Diabetic macular oedema (DME)
Croatian: Dijabetički makularni edem (DME)
English: Erosions and ulcerations of the respiratory epithelium in nasal turbinates in monkeys treated with aflibercept intravitreally were observed at systemic exposures in excess of the maximum human exposure.
Croatian: Erozije i ulceracije respiratornog epitela nosnih školjki opažene su u majmuna liječenih intravitrealno primijenjenim afliberceptom u kojih je sistemska izloženost bila veća od maksimalne izloženosti u ljudi.
English: • Treatment should be withheld in patients with rhegmatogenous retinal detachment or stage 3 or 4 macular holes.
Croatian: • Liječenje treba obustaviti u bolesnika s regmatogenim odignućem mrežnice ili makularnim rupama 3. ili 4. stupnja.
English: A total of 121 patients were treated and evaluable for efficacy (90 with Eylea).
Croatian: Ukupno 121 bolesnik se liječio i bio pogodan za procjenu djelotvornosti (90 lijekom Eylea).
English: 100 Weeks
Croatian: 100 tjedana
English: Injection with Eylea has a minor influence on the ability to drive and use machines due to possible temporary visual disturbances associated either with the injection or the eye examination.
Croatian: Injekcija lijeka Eylea malo utječe na sposobnost upravljanja vozilima i rada sa strojevima zbog mogućeg privremenog poremećaja vida povezanog s injekcijom ili pregledom oka.
English: When initiating Eylea therapy, caution should be used in patients with these risk factors for retinal pigment epithelial tears.
Croatian: Kad se započinje terapija lijekom Eylea, potreban je oprez kod bolesnika s ovim čimbenicima rizika za nastanak razderotine pigmentnog epitela mrežnice.
English: In patients with wet AMD and myopic CNV, these factors, in excess are involved in the abnormal formation of new blood vessels in the eye.
Croatian: U bolesnika s vlažnim AMD-om i miopijskim CNV-om, ovi čimbenici, kad su prisutni u suvišku, uključeni su u abnormalno stvaranje novih krvnih žila u oku.
English: The DRSS score was gradable in 73.7% of the patients in VIVIDDME and 98.3% of the patients in VISTADME.
Croatian: Rezultat DRSS-a mogao se ocijeniti u 73,7% bolesnika u ispitivanju VIVIDDME i 98,3% bolesnika u ispitivanju VISTADME.
English: Push the filter needle into the centre of the vial stopper until the needle is completely inserted into the vial and the tip touches the bottom or bottom edge of the vial.
Croatian: Potisnite filtar-iglu kroz središte čepa bočice sve dok cijela ne bude u bočici, tako da joj vrh dodiruje dno ili rub dna bočice.
English: After the initial injection, treatment is given monthly.
Croatian: Nakon prve injekcije, lijek se primjenjuje jedanput na mjesec.
English: Using aseptic technique withdraw all of the Eylea vial contents into the syringe, keeping the vial in an upright position, slightly inclined to ease complete withdrawal.
Croatian: Koristeći se aseptičkom tehnikom, izvucite sav sadržaj lijeka Eylea iz bočice u štrcaljku, držeći bočicu u uspravnom položaju i blago nagnutu, da se olakša izvlačenje cijelog sadržaja.
English: Vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) are members of the VEGF family of angiogenic factors that can act as potent mitogenic, chemotactic, and vascular permeability factors for endothelial cells.
Croatian: Vaskularni endotelni čimbenik rasta-A (VEGF-A) i placentni čimbenik rasta (PlGF) članovi su VEGF obitelji angiogenih čimbenika koji mogu djelovati kao jaki mitogeni i kemotaktični čimbenici i čimbenici vaskularne permeabilnosti za endotelne stanice.
English: The schedule for monitoring should therefore be determined by the treating physician and may be more frequent than the schedule of injections.
Croatian: Raspored kontrolnih pregleda treba stoga odrediti nadležni liječnik i pregledi mogu biti češći od rasporeda injekcija.
English: Myopic choroidal neovascularisation (myopic CNV) is a frequent cause of vision loss in adults with pathologic myopia.
Croatian: Neovaskularizacija žilnice kod kratkovidnosti (engl. myopic choroidal neovascularisation - myopic CNV) često je uzrok gubitka vida u odraslih s patološkom kratkovidnošću.
English: • Patient monitoring after intravitreal injection including monitoring for visual acuity and increase of intraocular pressure post-injection
Croatian: • Nadziranje bolesnika nakon intravitrealne injekcije, uključujući praćenje oštrine vida i povišenja intraokularnog tlaka nakon injekcije
English: In the laser group, where patients were eligible for rescue treatment with Eylea from week 24, the proportion of perfused patients increased to 78% by week 52.
Croatian: U skupini liječenoj laserom, u kojoj su bolesnici bili pogodni za spasonosno liječenje lijekom Eylea od 24. tjedna, udio bolesnika s perfuzijom porastao je do 78% do 52. tjedna.
English: PlGF can synergize with VEGFA in these processes, and is also known to promote leucocyte infiltration and vascular inflammation.
Croatian: PlGF može sinergistički djelovati s VEGF-A u ovim procesima, a zna se i da potiče inflitraciju leukocitima i upalu krvnih žila.
English: • Confirmation that the vial is for single use only
Croatian: • Potvrdu da je bočica namijenjena samo za jednokratnu primjenu
English: After the first 12 months of treatment with Eylea, the treatment interval may be extended based on your doctor's examination.
Croatian: Nakon prvih 12 mjeseci liječenja lijekom Eylea, vremenski razmak između doza može se produljiti ovisno o nalazima na liječničkom pregledu.
English: In the wet AMD phase III studies, there was an increased incidence of conjunctival haemorrhage in patients receiving anti-thrombotic agents.
Croatian: U ispitivanjima faze III kod vlažnog AMD, postojala je povećana incidencija krvarenja u spojnicu u bolesnika koji su primali antitrombotičke lijekove.
English: Elimination As Eylea is a protein-based therapeutic, no metabolism studies have been conducted.
Croatian: Budući da je lijek Eylea proteinsko terapijsko sredstvo, nisu provedena ispitivanja njegovog metabolizma.
English: Instructions for use of pre-filled syringe:
Croatian: Upute za uporabu napunjene štrcaljke:
English: As with all therapeutic proteins, there is a potential for immunogenicity with Eylea.
Croatian: Kao i sa svim terapijskim proteinima, postoji mogućnost imunogenosti lijeka Eylea.
English: In pharmacokinetic sub-studies in patients with CRVO, BRVO, DME or myopic CNV mean Cmax of free aflibercept in plasma were similar with values in the range of 0.03 to 0.05 microgram/ml and individual values not exceeding 0.14 microgram/ml.
Croatian: U farmakokinetičkim podispitivanjima u bolesnika s CRVO-om, BRVO-om, DME-om ili miopijskim CNV-om, srednje vrijednosti Cmax slobodnog aflibercepta u plazmi su bile slične vrijednostima raspona od 0,03 do 0,05 mikrograma/ml i individualne vrijednosti nisu prelazile 0,14 mikrograma/ml.
English: Eylea can help to stabilise, and in many cases, improve the vision loss related to wet AMD, CRVO, BRVO, DME and myopic CNV.
Croatian: Lijek Eylea može pridonijeti stabilizaciji i, u mnogim slučajevima, poboljšanju gubitka vida povezanog s vlažnim AMD-om, CRVO-om, BRVO-om, DME-om i miopijskim CNVom.
English: When the macula swells with fluid, central vision becomes blurry.
Croatian: Kada makula otekne zbog tekućine, centralni vid postane zamagljen.
English: A total of 862 patients were treated and evaluable for efficacy, 576 with Eylea.
Croatian: U ukupno 862 liječena bolesnika mogla se procijeniti djelotvornost, a njih 576 liječeno je lijekom Eylea.
English: In patients treated with 6 consecutive monthly injections of Eylea 2mg, there was a consistent, rapid and robust morphologic response (as measured by improvements in mean CRT) observed.
Croatian: U bolesnika liječenih sa šest uzastopnih mjesečnih injekcija lijeka Eylea 2 mg zabilježen je dosljedan, brz i robustan morfološki odgovor (mjeren kao poboljšanje srednjeg CRT-a).
English: In myopic CNV there is no experience with Eylea in the treatment of non-Asian patients, patients who have previously undergone treatment for myopic CNV, and patients with extrafoveal lesions.
Croatian: Kod miopijskog CNV-a nema iskustva s lijekom Eylea u liječenju bolesnika koji nisu azijatskog podrijetla, bolesnika koji su već bili liječeni zbog miopijskog CNV-a i bolesnika s ekstrafovealnim lezijama.
English: There is also no experience of treatment with Eylea in diabetic patients with uncontrolled hypertension.
Croatian: Ne postoji ni iskustvo s liječenjem lijekom Eylea bolesnika sa šećernom bolešću i nekontroliranom hipertenzijom.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Eylea in all subsets of the paediatric population in wet AMD, CRVO, BRVO, DME and myopic CNV populations (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja lijeka Eylea u svim podskupinama pedijatrijske populacije za vlažni AMD, CRVO, BRVO, DME i populacijama s miopijskim CNV (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: The interval between two injections should not be shorter than one month.
Croatian: Interval između dvije injekcije ne smije biti kraći od jednog mjeseca.
English: In CRVO and BRVO, retinal ischaemia occurs and signals the release of VEGF which in turn destabilises the tight junctions, and promotes endothelial cell proliferation.
Croatian: Kod CRVO i BRVO, nastupa ishemija mrežnice što signalizira oslobađanje VEGF-a, koji onda destabilizira čvrste spojeve i potiče proliferaciju endotelnih stanica.
English: Active severe intraocular inflammation.
Croatian: Aktivna teška intraokularna upala.