FrancophonIA/ELRC3.0 huggingface dataset:
English: However, children previously treated with Aptivus oral solution and becoming 12 years of age should be switched to capsules, particularly because of the more favourable safety profile of the capsules.
Slovenian: Toda za otroke, ki so se do 12. leta zdravili z zdravilom Aptivus peroralna raztopina, je prehod na kapsule potreben, zlasti zaradi ugodnejših varnostnih lastnosti kapsul.
English: These occur particularly when Aptivus or other protease inhibitors are taken together with nucleoside analogues.
Slovenian: Pojavljajo se predvsem ob hkratnem jemanju zdravila Aptivus ali drugih zaviralcev proteaze in nukleozidnih analogov.
English: If your child takes other medicines at the same time as Aptivus and ritonavir, this can strengthen or weaken the effect of the medicines.
Slovenian: Če vaš otrok sočasno jemlje druga zdravila z zdravilom Aptivus in ritonavirjem, to lahko okrepi ali oslabi učinek zdravil.
English: This adverse reaction was identified through post-marketing surveillance but not observed in randomised controlled clinical trials (n=6300).
Slovenian: Ta neželeni učinek so odkrili med nadzorom uporabe zdravila po začetku trženja, ne pa tudi v nadzorovanih kliničnih preskušanjih z naključno razvrstitvijo bolnikov (n = 6300).
English: These drug-drug interactions may reduce the effectiveness of HIV protease inhibitors and/or boceprevir when co-administered.
Slovenian: Te interakcije zdravil lahko pri sočasni uporabi zmanjšajo učinkovitost zaviralcev proteaze HIV in/ali boceprevirja.
English: Do not give Aptivus - if your child is allergic to tipranavir or any of the other ingredients of this medicine (listed in section 6) - if your child has moderate to severe liver problems.
Slovenian: Ne dajajte zdravila Aptivus - če je vaš otrok alergičen na tipranavir ali katero koli sestavino tega zdravila (navedeno v poglavju 6); - če ima vaš otrok zmerne do hude jetrne težave.
English: SPECIAL STORAGE CONDITIONS Do not store below 15°C.
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi do 15°C.
English: Insert the oral syringe into the adapter located in the neck of the bottle.
Slovenian: Brizgo vstavite v peroralni adapter v stekleničinem vratu.
English: It belongs to a group of medicines called protease inhibitors and is used in the treatment of Human Immunodeficiency Virus (HIV) infection.
Slovenian: Sodi v skupino zaviralcev proteaze, ki ga uporabljamo pri zdravljenju okužbe z virusom humane imunske pomanjkljivosti (HIV).
English: Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) Since there is no significant impact of nucleoside and nucleotide analogues on the P450 enzyme system no dosage adjustment of Aptivus is required when co-administered with these agents.
Slovenian: Nukleozidni in nukleotidni zaviralci reverzne transkriptaze (NRTI) Ker nukleozidni in nukleotidni analogi na encimski sistem P450 pomembneje ne vplivajo, odmerka zdravila Aptivus pri sočasnem dajanju s temi zdravili ni treba prilagoditi.
English: In use storage: 60 days, after first opening of the bottle.
Slovenian: Shranjevanje med uporabo: 60 dni po prvem odprtju steklenice.
English: Studies in human liver microsomes indicated tipranavir is an inhibitor of CYP 1A2, CYP 2C9, CYP 2C19 and CYP 2D6.
Slovenian: Raziskave s človeškimi jetrnimi mikrosomi so pokazale, da je tipranavir zaviralec CYP 1A2, CYP 2C9, CYP 2C19 in CYP 2D6.
English: Aptivus is supplied in bottles containing 120 capsules.
Slovenian: Zdravilo Aptivus je na voljo v steklenicah po 120 kapsul.
English: The potential net effect of tipranavir with ritonavir on CYP 2D6 is inhibition, because ritonavir is also a CYP 2D6 inhibitor.
Slovenian: Možen neto učinek tipranavirja ob ritonavirju na CYP 2D6 je zaviranje, ker je ritonavir tudi zaviralec CYP 2D6.
English: Patients using clarithromycin at doses higher than 500 mg twice daily should be carefully monitored for signs of toxicity of clarithromycin and tipranavir.
Slovenian: Bolnike, ki jemljejo večje odmerke klaritromicina od 500 mg dvakrat na dan, moramo natančno spremljati, da bi odkrili morebitne znake toksičnosti klaritromicina in tipranavirja.
English: Typically, such reactions have been observed within the first few weeks or months of initiation of CART.
Slovenian: Takšne reakcije so se značilno pojavljale prvih nekaj tednov ali mesecev po začetku kombiniranega protiretrovirusnega zdravljenja.
English: These effects are called interactions, and can lead to serious side effects, or prevent proper control of other conditions your child may have.
Slovenian: Te učinke imenujemo interakcije in lahko povzročijo resne neželene učinke ali preprečijo ustrezen nadzor otrokovih drugih bolezni.
English: Isolates with baseline fold change of >0 to 3 are considered susceptible; isolates with >3 to 10 fold changes have decreased susceptibility; isolates with >10 fold changes are resistant.
Slovenian: Izolati z izhodiščno stopnjo razlike občutljivosti > 0 do 3 veljajo za občutljive, izolati s stopnjo razlike > 3 do 10 imajo zmanjšano občutljivost in izolati s stopnjo razlike > 10 so odporni.
English: Fluconazole doses 200 mg/day are not recommended.
Slovenian: Odmerkov flukonazola nad 200 mg na dan ne priporočamo.
English: Patients should be monitored for opiate withdrawal syndrome.
Slovenian: Bolnike je treba spremljati zaradi sindroma odvzema opiatov.
English: Your child's doctor will test for these changes.
Slovenian: Otrokov zdravnik bo opravil preiskave glede teh sprememb.
English: Endothelin receptor antagonists Bosentan
Slovenian: Antagonisti endotelinskih receptorjev Bosentan
English: This score has been determined from the selected RESIST patient population having specific mutation inclusion criteria and therefore extrapolation to a wider population mandates caution.
Slovenian: To oceno so določili pri izbrani populaciji bolnikov iz raziskave RESIST, za katere so veljala posebna vključitvena merila, zato moramo biti previdni pri njeni ekstrapolaciji na širšo populacijo bolnikov.
English: Clinical isolates that exhibited a  10-fold decrease in tipranavir susceptibility harboured 8 or more tipranavir-associated mutations.
Slovenian: Klinični izolati z  10-krat zmanjšano občutljivostjo za tipranavir so imeli 8 ali več s tipranavirjem povezanih mutacij.
English: Aptivus capsules should be taken with food.
Slovenian: Zdravilo Aptivus kapsule je treba jemati skupaj s hrano.
English: In cases where co-administration is necessary, the dose of 10 mg atorvastatin daily should not be exceeded.
Slovenian: Kadar je potrebno sočasno dajanje zdravil, ne smemo prekoračiti odmerka 10 mg atorvastatina na dan.
English: Contains macrogolglycerol ricinoleate, sorbitol and ethanol (see package leaflet for further information)
Slovenian: Vsebuje makrogolglicerol ricinolat, sorbitol in etanol (za podrobnejše informacije glejte navodilo za uporabo).
English: These factors lead to the conclusion that the benefits outweigh the risks of Aptivus oral solution only in children between 2 and 12 years of age without any other therapeutic option (see section 4.1).
Slovenian: Na podlagi navedenega lahko sklepamo, da je korist peroralne raztopine Aptivus večja od tveganja samo pri otrocih od 2. do 12. leta, za katere ne obstaja druga možnost zdravljenja (glejte poglavje 4.1).
English: Before taking Aptivus it should be checked that the oral solution is clear and whether there are crystals or other particles at the bottom of the bottle.
Slovenian: Pred uporabo zdravila Aptivus je treba preveriti ali je peroralna raztopina prozorna in ali so na dnu steklenice kristali.
English: Aptivus soft capsules contain alcohol (7% ethanol, ie 100 mg per capsule or up to 200 mg per dose) which can produce disulfiram-like reactions when co-administered with disulfiram or other medicinal products which produce this reaction (e.g. metronidazole).
Slovenian: Mehke kapsule zdravila Aptivus vsebujejo alkohol (7% etanol, to je 100 mg v eni kapsuli ali do 200 mg v enem odmerku), ki lahko povzroči disulfiramske reakcije, če ga dajemo sočasno z disulfiramom ali drugimi zdravili, ki jih sicer povzročajo (na primer metronidazolom).
English: A 5 ml oral syringe and adapter is supplied for dosing.
Slovenian: Za odmerjanje sta priložena 5-mililitrska peroralna brizga in adapter.
English: Dosage reductions of rifabutin by at least 75% of the usual 300 mg/day are recommended (ie 150 mg on alternate days, or three times per week).
Slovenian: Priporočamo zmanjšanje odmerka rifabutina za najmanj 75% običajnega odmerka, ki je 300 mg na dan (to je 150 mg vsak drugi dan ali 3-krat na teden).
English: Patients receiving Aptivus or any other antiretroviral therapy may continue to develop opportunistic infections and other complications of HIV-1 infection.
Slovenian: Pri bolnikih, ki prejemajo zdravilo Aptivus ali katerokoli drugo protivirusno zdravilo, se lahko še naprej pojavljajo oportunistične okužbe in drugi zapleti okužbe s HIV-1.
English: The human immunodeficiency virus (HIV-1) encodes an aspartyl protease that is essential for the cleavage and maturation of viral protein precursors.
Slovenian: Virus humane imunske pomanjkljivosti (HIV-1) kodira aspartil-proteazo, ki je nujna za cepitev in dozorevanje predhodnikov virusne beljakovine.
English: Baseline phenotypic susceptibility was evaluated in 454 baseline patient samples.
Slovenian: Izhodiščno fenotipsko občutljivost so ovrednotili pri 454 izhodiščnih bolniških vzorcih.
English: In an open-label, dose-finding study of tipranavir plus ritonavir (Trial 1182.14), 28 children who were 12 years of age or above received Aptivus capsules.
Slovenian: V odprti raziskavi za določitev odmerka tipranavirja z ritonavirjem (raziskava 1182.14), je 28 otrok, starih 12 let ali več, prejemalo kapsule Aptivus.
English: If the co-administration with bupropion is judged unavoidable, this should be done under close clinical monitoring for bupropion efficacy, without exceeding the recommended dosage, despite the observed induction.
Slovenian: Če je sočasno dajanje bupropiona nujno potrebno, je treba bupropionovo učinkovitost natančno klinično spremljati in paziti, da ne bi prekoračili njegovega priporočenega odmerka, ne glede na indukcijo.
English: Due to limitations in the study design (e.g. nonrandomized switch allowed according to patient/clinician decision), any comparisons between patients taking capsules and oral solution are not meaningful.
Slovenian: Zaradi pomanjkljive oblike študije (dovoljena je bila na primer zamenjava oblike zdravila brez naključne izbire, ki je temeljila na odločitvi bolnika in kliničnega zdravnika), primerjave med bolniki, ki jemljejo kapsule in peroralno raztopino niso smiselne.
English: If there is more than a thin layer of crystals at the bottom of the bottle or uncertainty about the amount of crystals observed, the bottle should be returned for a replacement as soon as possible.
Slovenian: Če je na njenem dnu več kristalov kot le tanek sloj ali ste o količini kristalov negotovi, steklenico čim prej vrnite in nadomestite z novo.
English: There are no data available indicating that omeprazole or esomeprazole dose adjustments will overcome the observed pharmacokinetic interaction.
Slovenian: Ni podatkov, ki bi kazali, da prilagoditev odmerka omeprazola ali esomeprazola prepreči farmakokinetično interakcijo.
English: By contrast, evaluation of the steady-state plasma tipranavir trough concentrations at 10-14 h after dosing from the RESIST-1 and RESIST-2 studies demonstrate that females generally had higher tipranavir concentrations than males.
Slovenian: Nasprotno, pa ocena koncentracij tipranavirja v ravnovesnem stanju pred naslednjim odmerkom, 10-14 ur po dajanju v raziskavah RESIST-1 in RESIST-2 kaže, da so koncentracije tipranavirja pri ženskah na splošno večje kot pri moških.
English: The exact dose should be measured using the supplied measuring syringe and adapter, as follows:
Slovenian: Odmerek je treba natančno izmeriti s priloženo odmerno brizgo in adapterjem po naslednje postopku:
English: rilpivirine: If you are taking rilpivirine, your doctor will monitor you closely.
Slovenian: - Rilpivirin: Če jemljete rilpivirin, bo vaš zdravnik zdravljenje natančno spremljal.
English: An increase in gastric pH that may result from H2-receptor antagonist therapy is not expected to have an impact on tipranavir plasma concentrations.
Slovenian: Povečanje želodčnega pH, ki ga lahko povzroči zdravljenje z zaviralci receptorjev H2, predvidoma ne vpliva na koncentracijo tipranavirja v plazmi.
English: Further information on possible side effects related to combination antiretroviral treatment: - Bleeding - Increased bleeding.
Slovenian: Drugi podatki o možnih neželenih učinkih, ki se pojavijo pri kombiniranem protiretrovirusnem zdravljenju: -Krvavitev: povečane krvavitve.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete nosečnost, se posvetujte s svojim zdravnikom ali farmacevtom, preden vzamete to zdravilo.
English: Concomitant use of Aptivus/ritonavir caused a decrease of etravirine exposure that could significantly impair the virologic response to etravirine.
Slovenian: Pri sočasni uporabi zdravila Aptivus/ritonavirja se je zmanjšala izpostavljenost etravirinu, kar bi lahko pomembno poslabšalo virološki odziv na etravirin.
English: It blocks an enzyme called protease that is involved in the reproduction of HIV.
Slovenian: Zavira encim proteazo, ki sodeluje pri razmnoževanju HIV.
English: The influence of moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment on the multiple dose pharmacokinetics of either tipranavir or ritonavir has so far not been investigated.
Slovenian: Vpliva zmerno hude (stopnje B po Child-Pughovi razvrstitvi) ali hude jetrne okvare (stopnje C po Child-Pughovi razvrstitvi) na farmakokinetiko tipranavirja ali ritonavirja po večkratnih odmerkih do zdaj niso raziskovali.
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Slovenian: Če boste opazili kakršnekoli znake okužbe ali druge simptome, na primer mišično oslabelost ali oslabelost, ki se najprej pojavi v dlaneh in stopalih in nato širi proti trupu, palpitacije, tremor ali hiperaktivnost, zaradi potrebnega zdravljenja nemudoma obvestite zdravnika.
English: This study was also conducted with Aptivus oral solution 500 mg with ritonavir 200 mg and showed the same CYP P450 and P-gp interactions as the Aptivus capsule 500 mg with ritonavir 200 mg. Based on the results from this study, Aptivus oral solution might be expected to have a similar interaction profile as the capsules.
Slovenian: Raziskavo so izvedli tudi z zdravilom Aptivus peroralna raztopina 500 mg ob ritonavirju po 200 mg in med njegovim jemanjem so se pojavile enake interakcije s CYP P450 in P-gp kot ob zdravilu Aptivus kapsule 500 mg ob ritonavirju po 200 mg. Na podlagi izsledkov te raziskave lahko pričakujemo, da ima zdravilo Aptivus peroralna raztopina podoben profil interakcij kot kapsule.
English: This will depend on, for example: which other medicines your child has already taken for HIV which medicines your child's HIV is resistant to.
Slovenian: To bo na primer odvisno od tega: - katera druga zdravila proti virusu HIV je vaš otrok že jemal, - proti katerim zdravilom je HIV pri vašem otroku odporen.
English: The clinical relevance of this reduction has not been established, but may decrease the efficacy of zidovudine.
Slovenian: Klinični pomen tega zmanjšanja ni znan, vendar lahko zmanjša zidovudinovo učinkovitost.
English: In the tipranavir and comparator arms median baseline CD4 cell counts were 158 and 166 cells/mm
Slovenian: V skupini, ki je prejemala tipranavir, in primerjani skupini, je bilo srednje začetno število celic CD4 158 in 166 celic/mm
English: Tipranavir inhibits the replication of laboratory strains of HIV-1 and clinical isolates in acute models of T-cell infection, with 50% and 90% effective concentrations (EC50 and EC90) ranging from 0.03 to 0.07 µM (18-42 ng/ml) and 0.07 to 0.18 µM (42-108 ng/ml), respectively.
Slovenian: Tipranavir zavira replikacijo laboratorijskih sevov HIV-1 in kliničnih izolatov pri akutnih modelih okužbe celic T v 50- in 90-odstotni učinkoviti koncentraciji (EC50 in EC90) v razponu 0,03 do 0,07 µM (18 do 42 ng/ml) in 0,07 do 0,18 µM (42 do 108 ng/ml).
English: Potent inhibition of CYP 2D6 and both hepatic and intestinal CYP 3A4 activities were observed.
Slovenian: Prišlo je do močnega zaviranja CYP 2D6 in obeh, jetrne in črevesne aktivnosti CYP 3A4.
English: Dosage of methadone may need to be increased.
Slovenian: Včasih je treba odmerek metadona zmanjšati.
English: You must not breast-feed your baby because it is possible that the baby can become HIV-infected through the breast milk.
Slovenian: Otroka ne smete dojiti, ker se lahko z materinim mlekom okuži s HIV.
English: Clinical studies of Aptivus did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects (see section 5.2).
Slovenian: V kliničnih študijah o zdravilu Aptivus je sodelovalo premajhno število oseb, starih 65 let in starejših, da bi lahko določili, ali se na zdravljenje odzivajo drugače kot mlajše osebe (glejte poglavje
English: Most patients were able to continue treatment with tipranavir with ritonavir.
Slovenian: Večina bolnikov je lahko zdravljenje s tipranavirjem ob ritonavirju nadaljevala.
English: Remove the syringe cap covering the tip of the oral syringe (the cap will not be attached if this is the first time the oral syringe has been used) and insert the oral syringe into the adapter located in the neck of the bottle.
Slovenian: Snemite zaporko na vrhu peroralne brizge (zaporka ni pritrjena, če je peroralna brizga uporabljena prvič) in peroralno brizgo vstavite v adapter v stekleničnem vratu.
English: This medicinal product contains 7 vol % ethanol (alcohol), i.e. up to 400 mg per daily dose, equivalent to 8 ml of beer, or less than 4 ml of wine.
Slovenian: Zdravilo vsebuje 7 vol % etanola (alkohol), to je do 400 mg v dnevnem odmerku, kar ustreza 8 ml piva ali manj kot 4 ml vina.
English: In a clinical study where ritonavir 100 mg capsules bid were coadministered with 50 µg intranasal fluticasone propionate (4 times daily) for 7 days in healthy subjects, the fluticasone propionate plasma levels increased significantly, whereas the intrinsic cortisol levels decreased by approximately 86% (90% confidence interval 82-89%).
Slovenian: V klinični študiji, v kateri so kapsule ritonavirja po 100 mg, 2krat na dan, dajali sočasno s 50 μg intranazalnega flutikazon propionata (4-krat na dan) 7 dni zdravim osebam, so se ravni flutikazon propionata v plazmi pomembno povečale, medtem ko so se ravni intrinzičnega kortizola zmanjšale za približno 86% (90-odstotni interval zaupanja 8289%).
English: Rarely these muscle disorders have been serious, involving breakdown of muscle tissue (rhabdomyolysis).
Slovenian: Mišične motnje so bile le redko resne (rabdomioliza).
English: Whilst the changes in clarithromycin parameters are not considered clinically relevant, the reduction in the 14-OH metabolite AUC should be considered for the treatment of infections caused by Haemophilus influenzae in which the 14-OH metabolite is most active.
Slovenian: Spremembe parametrov klaritromicina ne veljajo za klinično pomembne, zmanjšanje AUC presnovka 14-OH pa je treba upoštevati pri zdravljenju okužb s Haemophilusom influenzae, pri katerih je presnovek 14-OH zelo aktiven.
English: If you have haemophilia type A and B, you may experience increased bleeding.
Slovenian: Če imate hemofilijo tipa A in B, se lahko pri vas povečajo krvavitve.
English: No specific signs and symptoms of overdose are known.
Slovenian: Specifični znaki in simptomi, ki se pojavijo po prevelikem odmerku, niso znani.
English: In a study conducted in rats with tipranavir at systemic exposure levels (AUC) equivalent to human exposure at the recommended clinical dose, no adverse effects on mating or fertility were observed.
Slovenian: V študiji pri podganah, v kateri je raven tipranavirja povzročila sistemsko izpostavljenost (AUC), ki je bila enaka izpostavljenosti pri človeku po dajanju priporočenega kliničnega odmerka, niso zasledili neželenih učinkov na parjenje ali plodnost.
English: Caution should be used when prescribing carbamazepine, phenobarbital, and phenytoin.
Slovenian: Antikonvulzivi Previdni moramo biti, kadar predpisujemo karbamazepin, fenobarbital in fenitoin.
English: If you have liver disease or hepatitis, your doctor will decide if you need additional testing.
Slovenian: Če imate jetrno bolezen ali hepatitis, bo zdravnik presodil o potrebi po dodatnih preiskavah.
English: Aptivus therapy should be discontinued in patients experiencing ASAT or ALAT elevations greater than 10X ULN, or developing signs or symptoms of clinical hepatitis during therapy.
Slovenian: Zdravljenje z zdravilom Aptivus moramo ukiniti pri bolnikih, pri katerih se ASAT ali ALAT povečata na več kot 10-kratno zgornjo normalno vrednost ali se pri njih med zdravljenjem razvijejo znaki ali simptomi kliničnega hepatitisa.
English: Aptivus should only be used as part of an active combination antiretroviral regimen in patients with no other therapeutic options (see sections 4.4 and 5.1).
Slovenian: Zdravilo Aptivus lahko uporabljamo samo v sklopu aktivnega protiretrovirusnega režima zdravljenja pri bolnikih, pri katerih ni drugih možnosti zdravljenja (glejte poglavje 4.4 in 5.1)
English: The Summary of Product Characteristics of ritonavir must therefore be consulted prior to initiation of therapy with Aptivus (especially as regards the contraindications, warnings and undesirable effects sections).
Slovenian: Preden uvedemo zdravljenje z zdravilom Aptivus, moramo pogledati v Povzetek glavnih značilnosti ritonavirja (zlasti kontraindikacije, opozorila in neželene učinke).
English: The clinical significance of these observations has not been fully explored.
Slovenian: Klinični pomen teh pojavov ni povsem raziskan.
English: Mild to moderate rash, including: - hives - rash with flat or raised small red spots - sensitivity to the sun have been reported in approximately 1 in 10 patients receiving Aptivus.
Slovenian: O blagem do zmernem izpuščaju, ki vključuje: koprivnico, izpuščaj s ploskimi ali privzdignjenimi majhnimi rdečimi lisami, občutljivost na sonce, so poročali pri približno 1 od 10 bolnikov, ki so jemali zdravilo Aptivus.
English: Co-administration of valaciclovir, tipranavir and low dose ritonavir was not associated with clinically relevant pharmacokinetic effects.
Slovenian: Sočasno dajanje valaciklovirja, tipranavirja in majhnih odmerkov ritonavirja ni bilo povezano s klinično pomembnimi farmakokinetičnimi učinki.
English: Tipranavir pharmacokinetics have not been studied in patients with renal impairment.
Slovenian: Farmakokinetike tipranavirja pri bolnikih z ledvično okvaro niso proučevali.
English: With repeated dosing, tipranavir plasma concentrations are lower than predicted from single dose data, presumably due to hepatic enzyme induction.
Slovenian: Po večkratnih odmerkih je plazemska koncentracija tipranavirja manjša, kot bi pričakovali po podatkih za enkratni odmerek, kar je verjetno posledica indukcije jetrnih encimov.
English: If you suffer increased bleeding you should see your doctor immediately.
Slovenian: Če se povečajo krvavitve, se morate nemudoma posvetovati z zdravnikom.
English: Do NOT stop taking Aptivus unless your doctor instructs you to do so.
Slovenian: NE prenehajte jemati zdravila Aptivus, razen, če vam tako naroči zdravnik.
English: The most serious adverse reactions include hepatic impairment and liver toxicity.
Slovenian: Najresnejši neželeni učinki so jetrna okvara in jetrna toksičnost.
English: Food improves the tolerability of tipranavir with ritonavir.
Slovenian: Hrana izboljša prenašanje tipranavirja ob ritonavirju.