FrancophonIA/ELRC3.0 huggingface dataset:
English: Netupitant is a moderate inhibitor of CYP3A4 and can increase the exposure of chemotherapeutic agents that are substrates for CYP3A4 e.g. docetaxel (see section 4.5).
Danish: Netupitant er en moderat hæmmer af CYP3A4 og kan øge eksponeringen over for kemoterapi-stoffer, der er substrater for CYP3A4, f.eks. docetaxel (se pkt.
English: After administration of a single oral dose of 300 mg netupitant, mean plasma netupitant/plasma radioactivity ratios ranged from 0.13 to 0.49 over 96 h post-dose.
Danish: Efter administration af en enkelt oral dosis med 300 mg netupitant var det gennemsnitlige forhold af plasma-netupitant/plasma-radioaktivitet i intervallet fra 0,13 til 0,49 i løbet af 96 timer efter doseringen.
English: A high fat meal did not affect the Cmax and AUC of oral palonosetron.
Danish: Et måltid med højt fedtindhold påvirkede ikke Cmaks og AUC for oral palonosetron.
English: Akynzeo is indicated in adults for the: - Prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based cancer chemotherapy.
Danish: Akynzeo er indiceret til voksne til: - Forebyggelse af akut og sen kvalme og opkastning forbundet med højemetogen cisplatin-baseret cancerkemoterapi.
English: Titanium dioxide (E171) Yellow iron oxide (E172) Red iron oxide (E172)
Danish: Titandioxid (E171) Gul jernoxid (E172) Rød jernoxid (E172)
English: • coating of the tongue, difficulty swallowing, dry mouth, belching, abnormal taste after medicine intake
Danish: • belægning på tungen, synkebesvær, mundtørhed, opstød, unormal smagsfornemmelse efter lægemiddelindtagelsen
English: Delayed phase: 25 to 120 hours post-cisplatin treatment.
Danish: †Sen fase: 25 til 120 timer efter behandling med cisplatin.
English: 135 patients who received a single oral dose (netupitant 300 mg and palonosetron 0.5 mg) and 136 patients who received oral palonosetron 0.5 mg alone.
Danish: Virkningen af Akynzeo blev vurderet hos 135 patienter, der fik en enkelt oral dosis (netupitant 300 mg og palonosetron 0,5 mg), og hos 136 patienter, der fik oral palonosetron 0,5 mg alene.
English: In humans, netupitant is eliminated mainly by hepatic metabolism mediated by CYP3A4 with a marginal renal excretion.
Danish: Hos mennesker elimineres netupitant primært via levermetabolisme medieret via CYP3A4 med en marginal nyreudskillelse.
English: • The recommended dose is one capsule (each capsule contains 300 mg of netupitant and 0.5 mg of palonosetron).
Danish: • Den anbefalede dosis er én kapsel (hver kapsel indeholder 300 mg netupitant og 0,5 mg palonosetron).
English: If you are not sure, talk to your doctor, pharmacist or nurse before taking this medicine.
Danish: Er du i tvivl, så spørg lægen, apotekspersonalet eller sygeplejersken, før du tager dette lægemiddel.
English: Netupitant/palonosetron capsules, when given with a single oral dose of 60 μg ethinylestradiol and 300 μg levonorgestrel had no significant effect on the AUC of ethinylestradiol and increased the AUC of levonorgestrel by 1.4-fold; clinical effects on the efficacy of hormonal contraception are unlikely.
Danish: Når netupitant/palonosetron kapsler blev givet med en enkelt oral dosis på 60 μg ethinyløstradiol og 300 μg levonorgestrel, havde det ingen signifikant virkning på AUC for ethinyløstradiol, og det forøgede AUC for levonorgestrel 1,4 gange.
English: Akynzeo is taken before the chemotherapy to prevent sickness and feelings of sickness from developing.
Danish: Akynzeo tages før kemoterapi for at forhindre, at du udvikler opkastninger og kvalme.
English: • stomach problems including stomach discomfort, feeling bloated, nausea, pain, indigestion,
Danish: • maveproblemer, herunder mavebesvær, følelse af oppustethed, kvalme, smerter,
English: Co-administration with ketoconazole did not affect the pharmacokinetics of palonosetron.
Danish: Administration sammen med ketoconazol påvirkede ikke farmakokinetikken af palonosetron.
English: Primary endpoint Complete response Overall phase Major secondary endpoints Complete response Acute phase Delayed phase No emesis Acute phase Delayed phase Overall phase No significant nausea Acute phase Delayed phase Overall phase Acute phase: 0 to 24 hours post-cisplatin treatment.
Danish: Ingen emese Akut fase Sen fase Samlet fase Ingen signifikant kvalme Akut fase Sen fase Samlet fase ‡Akut fase: 0 til 24 timer efter behandling med cisplatin.
English: The symptoms of overdose may include headache, dizziness, constipation, anxiety, palpitations, euphoric mood and pain in the legs.
Danish: Symptomerne på overdosering kan omfatte hovedpine, svimmelhed, forstoppelse, angst, hjertebanken, euforisk humør og smerter i benene.
English: Akynzeo 300 mg/0.5 mg hard capsules netupitant/palonosetron
Danish: Akynzeo 300 mg/0,5 mg hårde kapsler netupitant/palonosetron
English: Palonosetron is mainly metabolised by CYP2D6, with minor contribution by CYP3A4 and CYP1A2 isoenzymes.
Danish: Palonosetron metaboliseres primært af CYP2D6, med mindre bidrag fra CYP3A4- og CYP1A2-isoenzymer.
English: Akynzeo 300 mg/0.5 mg hard capsules
Danish: Akynzeo 300 mg/0,5 mg hårde kapsler
English: The European Medicines Agency has waived the obligation to submit the results of studies with Akynzeo in all subsets of the paediatric population in prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based and moderately emetogenic cancer chemotherapy (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med Akynzeo i alle undergrupper af den pædiatriske population til forebyggelse af akut og sen kvalme og opkastning i forbindelse med højemetogen cisplatin-baseret og moderat emetogen cancerkemoterapi (se pkt.
English: • medicines with a narrow therapeutic range that are primarily metabolized by CYP3A4, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine, ergotamine, fentanyl,
Danish: • lægemidler med et snævert terapeutisk interval, der primært metaboliseres af CYP3A4, såsom ciclosporin, tacrolimus, sirolimus, everolimus, alfentanil, diergotamin, ergotamin, fentanyl eller quinidin
English: Akynzeo is used to help prevent adults with cancer feeling sick (nausea) or being sick (vomiting) while having cancer treatment called ‘chemotherapy'.
Danish: Akynzeo anvendes til at hjælpe voksne med kræft med at undgå at få kvalme eller kaste op, mens de får den kræftbehandling, der kaldes 'kemoterapi'.
English: In vitro data show that netupitant is a P-gp inhibitor.
Danish: In vitro-data viser, at netupitant er en P-gp-hæmmer.
English: Therefore, patients with known hypersensitivity to peanut or soya should be monitored closely for signs of an allergic reaction (see section 4.8).
Danish: Derfor skal patienter med en kendt overfølsomhed over for jordnødder eller soja overvåges nøje for tegn på en allergisk reaktion (se pkt.
English: Hard capsule content:
Danish: Indhold af hård kapsel:
English: In 12 cancer patients given a single oral dose of palonosetron 0.5 mg one hour prior to chemotherapy, Cmax was 0.93 ± 0.34 ng/mL and Tmax was 5.1 ± 5.9 hours.
Danish: Hos 12 cancerpatienter, der fik en enkelt oral dosis palonosetron 0,5 mg en time før kemoterapi, var Cmaks 0,93 ± 0,34 ng/ml, og Tmaks var 5,1 ± 5,9 timer.
English: Pack size containing 1 capsule in an aluminium blister or 4 x 1 hard capsules in aluminium perforated unit dose blisters.
Danish: Pakningsstørrelse med 1 kapsel i en aluminiumsblister eller 4 x 1 hård kapsel i perforerede enkeltdosis-aluminiumsblistre.
English: Highly Emetogenic Chemotherapy (HEC) study
Danish: Højemetogen kemoterapi (HEC)-studie
English: Renal excretion for netupitant is negligible.
Danish: Nyreudskillelsen af netupitant er ubetydelig.
English: Total systemic exposure to intravenous palonosetron increased by approximately 28% in severe renal impairment relative to healthy subjects.
Danish: Total systemisk eksponering over for intravenøs palonosetron blev øget med ca. 28 % hos personer med svært nedsat nyrefunktion i forhold til raske personer.
English: In healthy subjects given palonosetron capsules 0.5 mg, the terminal elimination half-life (t½) of palonosetron was 37 ± 12 hours (mean ± SD), and in cancer patients, t½ was 48 ± 19 hours.
Danish: Hos raske personer, der fik palonosetron i kapsler med 0,5 mg, var den terminale elimineringshalveringstid (t½) for palonosetron 37 ± 12 timer (gennemsnit ± SD), og t½ var 48 ± 19 timer hos cancerpatienter.
English: Akynzeo is taken to help prevent you feeling and being sick when you are having chemotherapy.
Danish: Akynzeo tages for at hjælpe dig med at forhindre, at du får kvalme og kaster op, når du får kemoterapi.
English: Furthermore, netupitant may also affect the efficacy of chemotherapeutic agents that need activation by CYP3A4 metabolism.
Danish: Desuden kan netupitant også påvirke virkningen af kemoterapeutiske stoffer, der skal aktiveres af CYP3A4-metabolismen.
English: In vitro data suggests that netupitant inhibits the efflux of transporter BCRP.
Danish: In vitro-data tyder på, at netupitant hæmmer effluks af transporteren BCRP.
English: After a single dose of approximately 0.75 mg intravenous palonosetron, the total body clearance of palonosetron in healthy subjects was 160 ± 35 mL/h/kg (mean ± SD) and renal clearance was 66.5± 18.2 mL/h/kg.
Danish: Efter en enkelt dosis med ca. 0,75 mg intravenøs palonosetron var den totale legemsclearance for palonosetron hos raske personer 160 ± 35 ml/t/kg (gennemsnit ± SD), og nyreclearance var 66,5 ± 18,2 ml/t/kg.
English: In a pooled analysis, females had a higher netupitant exposure compared to males; there was a 1.31-fold increase in Cmax, a 1.02 fold increase for AUC and a 1.36 fold increase in half-life.
Danish: Der var en forhøjelse i Cmaks på 1,31 gange, en forhøjelse af AUC på 1,02 gange og en forlængelse af halveringstiden på 1,36 gange.
English: Do not take Akynzeo if:
Danish: Tag ikke Akynzeo:
English: It may contain traces of lecithin - which comes from soya.
Danish: Medicinen kan indeholde spor af lecithin - som kommer fra soja.
English: Non-cardiac chest pain Product taste abnormal
Danish: Brystsmerter ikke fra hjertet Præparatet smager unormalt
English: Consequently, concomitant administration with strong CYP3A4 inhibitors (e.g., ketoconazole) should be approached with caution and concomitant administration with strong CYP3A4 inducers (e.g. rifampicin) should be avoided.
Danish: Som følge heraf bør administration sammen med kraftige CYP3A4-hæmmere (f.eks. ketoconazol) udføres med forsigtighed og administration sammen med kraftige CYP3A4 -induktorer (f.eks. rifampicin) bør undgås.
English: Limited data exist in patients with severe hepatic impairment (Child Pugh score ≥ 9).
Danish: Der foreligger begrænsede data fra patienter med svært nedsat leverfunktion (Child-Pugh-score ≥ 9).
English: Dexamethasone 8 mg twice a day
Danish: Dexamethason 8 mg to gange dagligt
English: It may also contain a trace of lecithin derived from soya.
Danish: Der kan også være spor af lecithin fra soja.
English: As such, the oral dexamethasone dose should be reduced by approximately 50% when co-administered with netupitant/palonosetron capsules (see section 4.2).
Danish: Den orale dexamethason-dosis bør som sådan reduceres med ca. 50 % ved administration sammen med netupitant/palonosetron kapsler (se pkt.
English: Netupitant AUC0-∞ and Cmax increased by 1.1 fold and 1.2 fold, respectively, after a high fat meal.
Danish: AUC0-∞ og Cmaks for netupitant var forhøjet med hhv. 1,1 gange og 1,2 gange efter et måltid med højt fedtindhold.
English: Cases of constipation with faecal impaction requiring hospitalisation have been reported in association with palonosetron 0.75 mg.
Danish: Der er blevet rapporteret tilfælde af indlæggelseskrævende forstoppelse med fækal retention i forbindelse med palonosetron 0,75 mg.
English: hiccups, wind or diarrhoea
Danish: fordøjelsesbesvær, hikke, luftafgang eller diarré
English: Absolute netupitant bioavailability data are not available in humans; based on data from two studies with intravenous netupitant, the bioavailability in humans is estimated to be greater than 60%.
Danish: Baseret på data fra to studier med intravenøst netupitant er biotilgængeligheden hos mennesker estimeret til at være over
English: The medicines in Akynzeo attach to the receptors in the nervous system through which serotonin and substance P work: netupitant (an NK1 receptor antagonist) blocks the receptors for substance P, and palonosetron (a 5HT3 receptor antagonist) blocks certain receptors for serotonin.
Danish: Kemoterapi-lægemidler kan få kroppen til at frigive stoffer, der kaldes serotonin og substans P. De stimulerer opkastningscentret i hjernen og giver dig kvalme eller får dig til at kaste op. Lægemidlerne i Akynzeo hæfter sig til receptorer i nervesystemet, som serotonin og substans P virker igennem: netupitant (en NK1-receptorantagonist) blokerer receptorerne for substans P, og palonosetron (en 5-HT3-receptorantagonist) blokerer visse receptorer for serotonin.
English: Co-administration of rifampicin did not affect the pharmacokinetics of palonosetron.
Danish: Administration sammen med rifampicin påvirkede ikke farmakokinetikken af palonosetron.
English: Blood bilirubin increased
Danish: Forhøjet niveau af bilirubin i blodet
English: • low levels of ‘neutrophils' - a kind of white blood cell which fight infections (shown in blood tests)
Danish: • lavt niveau af ‘neutrofiler' - en slags hvide blodlegemer, som bekæmper infektioner (kan ses i blodprøver)
English: Other medicines and Akynzeo
Danish: Brug af anden medicin sammen med Akynzeo
English: • high levels of creatine phosphokinase/ creatine phosphokinase MB - which indicates sudden decreased blood flow to the heart muscle (shown in blood tests)
Danish: • højt niveau af kreatinphosphokinase/kreatinphosphokinase MB - hvilket indikerer en pludselig nedsat blodforsyning til hjertemuskulaturen (kan ses i blodprøver)
English: Moderately Emetogenic Chemotherapy (MEC) study
Danish: Moderat emetogen kemoterapi (HEC)-studie
English: At a dose of 300 mg in humans, netupitant is a substrate and moderate inhibitor of CYP3A4.
Danish: Netupitant er ved en dosis på 300 mg et substrat og en moderat hæmmer af CYP3A4 hos mennesker.
English: Akynzeo (Netupitant 300 mg + Palonosetron 0.5 mg) Dexamethasone 12 mg
Danish: Akynzeo (netupitant 300 mg + palonosetron 0,5 mg) Dexamethason 12 mg
English: In vitro metabolism studies have suggested that CYP3A4 and, to a lesser extent, CYP2D6 and CYP2C9 are involved in the metabolism of netupitant.
Danish: In vitrometabolismestudier har tydet på, at CYP3A4 og i mindre grad CYP2D6 og CYP2C9 er involveret i netupitants metabolisme.
English: Name and address of the manufacturer(s) responsible for batch release
Danish: Navn og adresse på den fremstiller (de fremstillere), der er ansvarlig(e) for batchfrigivelse Helsinn Birex Pharmaceuticals Ltd.
English: Dosage adjustment is not considered necessary in patients with mild to severe renal impairment.
Danish: Det anses ikke for at være nødvendigt med en dosisjustering hos patienter med let til svært nedsat nyrefunktion.
English: • high level of ‘lymphocytes'- type of white blood cell which help the body fight disease (shown in blood tests)
Danish: • højt niveau af 'lymfocytter'- en type hvide blodlegemer, som hjælper kroppen med at bekæmpe sygdomme (kan ses i blodprøver)
English: If you stop taking Akynzeo
Danish: Hvis du holder op med at tage Akynzeo
English: Do not breast-feed if you are taking Akynzeo.
Danish: Du må ikke amme, hvis du tager Akynzeo.
English: Major secondary endpoints Complete response Acute phase
Danish: Primære endepunkt Fuldstændigt respons Samlet fase Vigtigste sekundære endepunkter Fuldstændigt respons Akut fase Sen fase†
English: If you forget to take Akynzeo
Danish: Hvis du har glemt at tage Akynzeo
English: In vitro metabolism studies have suggested that CYP2D6 and to a lesser extent, CYP3A4 and CYP1A2 are involved in the metabolism of palonosetron.
Danish: In vitro-metabolismestudier har tydet på, at CYP2D6 og i mindre grad CYP3A4 og CYP1A2 er involveret i palonosetrons metabolisme.
English: As such, no dosage adjustment is necessary for patients with mild to moderate hepatic impairment.
Danish: Ingen dosisjustering er som sådan nødvendig for patienter med let til moderat nedsat leverfunktion.
English: • numbness, blurred vision
Danish: • følelsesløshed, sløret syn
English: The signs may include hives, itch, angioedema, low blood pressure, throat tightness, chest tightness, dyspnoea, loss of consciousness.
Danish: Tegnene kan omfatte nældefeber, kløe, angioødem, lavt blodtryk, halssammensnøring, trykken for brystet, dyspnø, bevidsthedstab.
English: These conditions include patients with a personal or family history of QT prolongation, electrolyte abnormalities, congestive heart failure, bradyarrhythmia, conduction disturbances and in patients taking anti-arrhythmic medicinal products or other medicinal products that lead to QT prolongation or electrolyte abnormalities.
Danish: kongestivt hjertesvigt, bradyarytmi, ledningsforstyrrelser, og hos patienter, der tager lægemidler mod arytmi eller andre lægemidler, der fører til QT-forlængelse eller elektrolytforstyrrelser.
English: What you need to know before you take Akynzeo
Danish: Det skal du vide, før du begynder at tage Akynzeo
English: Palonosetron 0.5 mg Dexamethasone 20 mg
Danish: Palonosetron 0,5 mg Dexamethason 20 mg
English: Akynzeo Netupitant 300 mg Palonosetron 0.5 mg Dexamethasone 12 mg
Danish: Akynzeo netupitant 300 mg Palonosetron 0,5 mg Dexamethason 12 mg
English: In 36 healthy male and female subjects given a single oral dose of 0.5 mg palonosetron, maximum plasma concentration (Cmax) was 0.81 ± 1.66 ng/mL (mean ± SD) and time to maximum concentration (Tmax) was 5.1 ± 1.7 hours.
Danish: Hos 36 raske mænd og kvinder, der fik en enkelt oral dosis palonosetron på 0,5 mg var den maksimale plasmakoncentration (Cmaks) 0,81 ± 1,66 ng/ml (gennemsnit ± SD) og tiden til maks.
English: Day 1
Danish: Behandlingsprogram Dag 1
English: Each hard capsule contains 300 milligrams of netupitant and 0.5 milligrams of palonosetron (as hydrochloride).
Danish: Hver hård kapsel indeholder 300 milligram netupitant og 0,5 milligram palonosetron (som hydrochlorid).
English: Each hard capsule contains 300 mg of netupitant and palonosetron hydrochloride equivalent to 0.5 mg of palonosetron.
Danish: Hver hård kapsel indeholder 300 mg netupitant og palonosetronhydrochlorid svarende til 0,5 mg palonosetron.
English: Rare (≥1/10,000 to <1/1,000),
Danish: Ikke almindelig (≥ 1/1.000 til < 1/100), Sjælden (≥ 1/10.000 til < 1/1.000),
English: Blood creatine phosphokinase increased
Danish: Forhøjet niveau af kreatinphosphokinase i blodet
English: • feeling tired.
Danish: • træthedsfølelse.
English: Rare: (may affect up to 1 in 1,000 people)
Danish: Sjælden: (kan forekomme hos op til 1 ud af 1.000 personer)
English: • high level of white blood cells (shown in blood tests).
Danish: • højt niveau af hvide blodlegemer (kan ses i blodprøver).
English: • high levels of myoglobin - which indicates muscle injury (shown in blood tests)
Danish: • højt niveau af myoglobin - hvilket indikerer muskelskade (kan ses i blodprøver)
English: Each hard capsule contains three tablets (300 mg of netupitant), and one soft capsule (palonosetron hydrochloride equivalent to 0.5 milligrams of palonosetron).
Danish: Hver hård kapsel indeholder tre tabletter (300 mg netupitant) og en blød kapsel (palonosetronhydrochlorid svarende til 0,5 mg palonosetron).
English: • high levels of certain enzymes, including blood alkaline phosphatase and liver transaminases
Danish: • højt niveau af visse enzymer, herunder basisk fosfatase i blodet og levertransaminaser (kan ses i blodprøver)
English: • raised, itchy rash on the skin (hives)
Danish: • hævet, kløende udslæt på huden (nældefeber)
English: Croscarmellose sodium Colloidal hydrated silica Sodium stearyl fumarate Magnesium stearate
Danish: Natriumstearylfumarat Magnesiumstearat
English: Constipation Abdominal distension
Danish: Mave-tarm-kanalen Forstoppelse Abdominal distension
English: In 82 healthy subjects given a single oral dose of netupitant 300 mg, maximum plasma netupitant concentration (Cmax) was 486 ±268 ng/mL (mean ± SD) and median time to maximum concentration (Tmax) was 5.25 hours, the AUC was 15032 ± 6858 h.ng/mL.
Danish: Hos 82 raske personer, der fik en enkelt oral dosis netupitant på 300 mg, var den maksimale plasmakoncentration af netupitant (Cmaks) 486 ± 268 ng/ml (gennemsnit ± SD), og den mediane tid til maks.
English: Bundle branch block right Mitral valve incompetence Myocardial ischaemia Ventricular extrasystoles
Danish: Højresidigt grenblok Mitralklapinkompetens Myokardieiskæmi Ventrikulære ekstrasystoler
English: What Akynzeo contains
Danish: Akynzeo indeholder:
English: • low level of potassium (shown in blood tests)
Danish: • lavt niveau af kalium (kan ses i blodprøver)
English: Hard capsule shell:
Danish: Hård kapselskal:
English: The recommended oral dexamethasone dose should be reduced by approximately 50 % when coadministered with netupitant/palonosetron capsules (see section 4.5 and clinical studies administration schedule in section 5.1).
Danish: Den anbefalede dosis oral dexamethason bør reduceres med ca. 50 % ved administration sammen med netupitant/palonosetron kapsler (se pkt.
English: • low level of white blood cells (shown in blood tests)
Danish: • lavt niveau af hvide blodlegemer (kan ses i blodprøver)
English: Overall phase
Danish: Sen fase
English: The signs may include hives, skin rash, itching, difficulty breathing or swallowing, swollen mouth, face, lips, tongue or throat and sometimes a drop in blood pressure.
Danish: Tegnene kan omfatte nældefeber, hududslæt, kløe, vejrtræknings- eller synkebesvær, hævelse i mund, ansigt, læber, tunge eller hals og til tider et blodtryksfald.
English: • medicines for depression or anxiety called SNRIs (serotonin noradrenaline re-uptake inhibitors)
Danish: • lægemidler mod depression eller angst, der kaldes SNRI'er (serotoninnoradrenalingenoptagshæmmere) - såsom venlafaxin eller duloxetin.
English: • high levels of troponin - which indicates heart muscle dysfunction (shown in blood tests)
Danish: • højt niveau af troponin - som indikerer dysfunktion af hjertemusklen (kan ses i blodprøver)
English: Other side effects Tell your doctor, pharmacist or nurse if you notice any of the following side effects:
Danish: Fortæl det til lægen, apotekspersonalet eller sundhedspersonalet, hvis du får nogle af følgende bivirkninger:
English: The signs may include hives, skin rash, itching, difficulty breathing or swallowing, swollen mouth, face, lips, tongue or throat and sometimes a drop-in blood pressure.
Danish: Tegnene kan omfatte nældefeber, hududslæt, kløe, vejrtræknings- eller synkebesvær, hævelse i mund, ansigt, læber, tunge eller hals og undertiden blodtryksfald.
English: How Akynzeo works
Danish: Sådan virker Akynzeo
English: Decreased appetite Hypokalaemia
Danish: Nedsat appetit
English: • high levels of the pigment bilirubin - which indicates liver dysfunction (shown in blood tests)
Danish: • højt niveau af pigmentet bilirubin - hvilket indikerer leverdysfunktion (kan ses i blodprøver)
English: • ECG (electrocardiogram) problems (called ‘QT and PR interval prolongation', ‘conduction disorder', ‘tachycardia' and ‘atrioventricular block first degree')
Danish: • problemer på EKG'et (elektrokardiogrammet) (som kaldes ‘forlængelse af QT- eller PR
English: such as fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram or escitalopram
Danish: • lægemidler mod depression eller angst, der kaldes SSRI'er (selektive serotoningenoptagshæmmere) - såsom fluoxetin, paroxetin, sertralin, fluvoxamin, citalopram eller escitalopram
English: Liver transaminases increased
Danish: Forhøjet niveau af levertransaminaser
English: ‘bundle branch block right/left', and ‘atrioventricular block second degree')
Danish: ST-T-segment', ‘højre/venstre-sidigt grenblok' og ‘2.
English: How to take Akynzeo
Danish: Sådan skal du tage Akynzeo
English: Delayed phase Overall phase No significant nausea Acute phase
Danish: Ingen emese Akut fase Sen fase Samlet fase