FrancophonIA/ELRC3.0 huggingface dataset:
English: Hence, the CHMP recommended that Milnacipran Pierre Fabre Médicament/Impulsor be refused marketing authorisation.
Slovenian: Zato je CHMP priporočil zavrnitev dovoljenja za promet z zdravilom Milnacipran Pierre Fabre Médicament/Impulsor.
English: How was Milnacipran Pierre Fabre Médicament/Impulsor expected to work?
Slovenian: Kako naj bi zdravilo Milnacipran Pierre Fabre Médicament/Impulsor delovalo?
English: What was Milnacipran Pierre Fabre Médicament/Impulsor expected to be used for?
Slovenian: Za kaj naj bi se zdravilo Milnacipran Pierre Fabre Médicament/Impulsor uporabljalo?
English: Please open here
Slovenian: Prosimo, odprite tukaj.
English: The response rate in these patients was about 52%.
Slovenian: Stopnja odzivnosti pri teh bolnikih je bila okrog 52 %.
English: • At the request of the European Medicines Agency,
Slovenian: • na zahtevo Evropske agencije za zdravila;
English: Time on study (weeks)
Slovenian: čas v študiji (tedni)
English: Adults and older people
Slovenian: Odrasli in starejši ljudje
English: The most common ones are usually mild and will probably disappear after a short time.
Slovenian: Najpogostejši so navadno blagi in bodo verjetno v kratkem času izginili.
English: Use the entire contents.
Slovenian: Vsebino porabite v celoti.
English: Any SRE (+TIH)
Slovenian: katerikoli SRE (+TIH)
English: Patients aged 65 years and over
Slovenian: Bolniki, stari 65 let ali več
English: You should therefore be careful when driving, using machinery or performing other tasks that need full attention.
Slovenian: Zato morate biti previdni pri upravljanju motornih vozil, uporabi strojev in opravljanju drugih nalog, ki zahtevajo vašo celotno pozornost.
English: Unopened bottle: 3 years.
Slovenian: Neodprta plastenka: 3 leta
English: Currently available data are described in section 5.1 but no recommendation on a posology can be made.
Slovenian: Trenutno razpoložljivi podatki so opisani v poglavju 5.1, vendar priporočil o odmerjanju ni mogoče dati.
English: In most cases no specific treatment is required and the symptoms disappear after a short time (couple of hours or days).
Slovenian: V večini primerov ni potrebno nikakršno specifično zdravljenje in simptomi v kratkem (čez nekaj ur ali dni) izzvenijo.
English: Acquired Fanconi syndrome
Slovenian: pridobljen Fanconijev sindrom
English: Median time to normocalcaemia was 4 days.
Slovenian: Mediana časa do normalne vrednosti kalcija je bila 4 dni.
English: Read all of this leaflet carefully before you are given this medicine because it contains important information for you.
Slovenian: Natančno preberite navodilo, preden vam dajo zdravilo, ker vsebuje za vas pomembne podatke!
English: Mutagenicity and carcinogenic potential
Slovenian: Mutagenost in kancerogeni potencial
English: Use immediately after first opening.
Slovenian: Uporabite takoj po prvem odpiranju.
English: Zometa can be given to people aged 65 years and over.
Slovenian: Zdravilo Zometa lahko dajemo ljudem, ki so stari 65 let ali več.
English: In some instances the hypocalcaemia may be life-threatening.
Slovenian: Hipokalciemija je v nekaterih primerih lahko življenjsko ogrožujoča.
English: Follow carefully all instructions given to you by your doctor.
Slovenian: Skrbno se ravnajte po vseh navodilih, ki vam jih je dal vaš zdravnik.
English: CLcr is calculated from serum creatinine using the Cockcroft-Gault formula.
Slovenian: CLcr se izračuna iz serumskega kreatinina s Cockcroft-Gaultovo formulo.
English: Tell your doctor if you are or think that you may be pregnant.
Slovenian: Povejte zdravniku, če mislite, da ste noseči ali da bi utegnili biti noseči.
English: INFORMATION FOR THE HEALTHCARE PROFESSIONAL
Slovenian: INFORMACIJE ZA ZDRAVSTVENE DELAVCE
English: Subchronic and chronic toxicity
Slovenian: Subkronična in kronična toksičnost
English: There is no evidence to suggest that any extra precautions are needed.
Slovenian: Ni dokazov, ki bi kazali, da so potrebni kakšni posebni varnostni ukrepi.
English: These could be signs of bone damage in the ear.
Slovenian: To so lahko znaki poškodbe kosti v ušesu.
English: The time to onset of symptoms varied from one day to several months after starting treatment.
Slovenian: Čas do pojava simptomov je bil različen: od enega dneva do nekaj mesecev po začetku zdravljenja.
English: Attention should also be paid to the possibility of hypomagnesaemia developing during treatment.
Slovenian: Pozorni moramo biti tudi na možnost, da bi se med zdravljenjem razvila hipomagneziemija.
English: • To reduce the amount of calcium in the blood in adult patients where it is too high due to the presence of a tumour.
Slovenian: • zniževanje količine kalcija v krvi pri odraslih, kadar je ta prevelika zaradi prisotnosti tumorja.
English: 1.0 mg/dl or 88 µmol/l.
Slovenian: 1,0 mg/dl ali 88 µmol/l.
English: The following response rates were observed:
Slovenian: Ugotovili so naslednje stopnje odzivnosti:
English: Osteonecrosis of other anatomical sites
Slovenian: Osteonekroza na drugih anatomskih lokacijah
English: Acute toxicity
Slovenian: Akutna toksičnost
English: Your doctor, pharmacist or nurse knows how to store Zometa properly (see section 6).
Slovenian: Vaš zdravnik, farmacevt ali medicinska sestra vedo, kako je treba zdravilo Zometa pravilno shranjevati (glejte poglavje 6).
English: The reconstituted solution is stable for 24 hours at 2°C - 8°C.
Slovenian: Rekonstituirana raztopina je stabilna 24 ur pri 2 °C - 8 °C.
English: Many of these patients were also receiving chemotherapy and corticosteroids and had signs of local infection including osteomyelitis.
Slovenian: Izmed teh bolnikov so številni prejemali tudi kemoterapijo in kortikosteroide in imeli znake lokalne infekcije, vključno z osteomielitisom.
English: The total body clearance is 5.04 ± 2.5 l/h, independent of dose, and unaffected by gender, age, race, and body weight.
Slovenian: Skupni telesni očistek je 5,04  2,5 l/h, je neodvisen od odmerka in nanj ne vplivajo spol, starost, rasa in telesna masa.
English: The mechanism behind the increased incidence of atrial fibrillation in this single clinical trial is unknown.
Slovenian: Mehanizem, na katerem temelji zvišana pojavnost atrijske fibrilacije v tem edinem kliničnem preskušanju, ni znan.
English: Aseptic techniques must be followed during the preparation of the infusion.
Slovenian: Pri pripravljanju infuzije je treba uporabljati aseptične tehnike.
English: As only limited clinical data are available in patients with severe hepatic insufficiency, no specific recommendations can be given for this patient population.
Slovenian: Ker so za bolnike s težko insuficienco jeter na voljo le omejeni klinični podatki, za to skupino bolnikov ne moremo dati specifičnih priporočil.
English: If the solution is not used immediately, it should be stored in a refrigerator at 2°C - 8°C.
Slovenian: Če raztopine ne uporabite takoj, jo je treba shraniti v hladilnik pri temperaturi 2 °C 8 °C.
English: Pharmacotherapeutic group: Drugs for treatment of bone diseases, bisphosphonates, ATC code: M05BA08
Slovenian: Farmakoterapevtska skupina: zdravila za zdravljenje bolezni kosti, difosfonati, oznaka ATC: M05BA08
English: There are no adequate data on the use of zoledronic acid in pregnant women.
Slovenian: Ni zadostnih podatkov o uporabi zoledronske kisline pri nosečnicah.
English: The majority of the reports refer to cancer patients following tooth extractions or other dental surgeries.
Slovenian: Večina poročil se nanaša na bolnike z rakom po ekstrakciji zoba ali drugih zobozdravniških operativnih posegih.
English: Over the first 24 hours, 39 ± 16% of the administered dose is recovered in the urine, while the remainder is principally bound to bone tissue.
Slovenian: V prvih 24 urah se izloči v urin 39  16 % danega odmerka, preostanek pa se predvsem veže v kostno tkivo.
English: In some instances, the hypocalcaemia may be life-threatening (see section 4.8).
Slovenian: Hipokalciemija je v nekaterih primerih lahko življenjsko ogrožujoča (glejte poglavje 4.8).
English: The treatment effects were less pronounced in patients with blastic lesions.
Slovenian: Učinki zdravljenja so bili manj izraziti pri bolnikih z blastnimi lezijami.
English: If any of these apply to you, tell your doctor straight away.
Slovenian: Če se pri vas razvije karkoli od navedenega, takoj obvestite svojega zdravnika.
English: Day 7
Slovenian: 7. dan
English: Each pack contains the vial with concentrate.
Slovenian: Vsako pakiranje vsebuje vialo s koncentratom.
English: Other medicines and Zometa Tell your doctor if you are taking, have recently taken or might take any other medicines.
Slovenian: Druga zdravila in zdravilo Zometa Obvestite zdravnika, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
English: Your doctor will recommend that you drink enough water before each treatment to help prevent dehydration.
Slovenian: - Zdravnik vam bo priporočil, da pred vsako infuzijo spijete dovolj vode, kar bo pomagalo preprečiti dehidracijo.
English: What Zometa is and what it is used for
Slovenian: Kaj je zdravilo Zometa in za kaj ga uporabljamo
English: Since those patients were retreated with the 8 mg dose only, there are no data available allowing comparison with the 4 mg zoledronic acid dose.
Slovenian: Ker so bili ti bolniki ponovno zdravljeni samo z odmerkom 8 mg, ni na voljo podatkov, ki bi omogočali primerjavo z odmerkom 4 mg zoledronske kisline.
English: Baseline creatinine clearance (ml/min)
Slovenian: Izhodiščni očistek kreatinina (ml/min)
English: In particular there was no clear evidence of efficacy on incidence of fracture or on pain.
Slovenian: V študiji namreč niso mogli jasno potrditi učinkovitosti na pogostnost zlomov ali na bolečino.
English: Arthritis and joint swelling as a symptom of acute phase reaction
Slovenian: artritis in otekline sklepov kot simptoma reakcije akutne faze
English: The safety and efficacy of zoledronic acid in children aged 1 year to 17 years have not been established.
Slovenian: Varnost in učinkovitost zoledronske kisline pri otrocih, starih 1 do 17 let, nista bili dokazani.
English: - If you are being treated to reduce the amount of calcium in your blood, you will normally only be given one infusion of Zometa.
Slovenian: - Če prejemate zdravilo za zniževanje količine kalcija v krvi, boste običajno prejeli samo eno infuzijo zdravila Zometa.
English: It is an inhibitor of osteoclastic bone resorption.
Slovenian: Je zaviralec osteoklastne resorpcije kosti.
English: Most patients had relief of symptoms after stopping treatment.
Slovenian: Pri večini bolnikov je prišlo do olajšanja po prekinitvi zdravljenja.
English: It is currently unclear whether zoledronic acid causes this irregular heart rhythm but you should report it to your doctor if you experience such symptoms after you have received zoledronic acid.
Slovenian: Zaenkrat ni jasno, ali to nepravilno bitje srca povzroča zoledronska kislina, kljub temu pa morate zdravniku sporočiti, če pri vas pride do takih simptomov po tem, ko ste prejeli zoledronsko kislino.
English: What you need to know before you are given Zometa
Slovenian: Kaj morate vedeti, preden vam bodo dali zdravilo Zometa
English: Patients receiving zoledronic acid 4 mg reported less increase in pain than those receiving placebo, and the difference reached significance at months 3, 9, 21 and 24.
Slovenian: Bolniki, ki so dobivali zoledronsko kislino 4 mg, so poročali o manjšem porastu bolečin kot tisti, ki so dobivali placebo, ta razlika pa je dosegla statistično značilnost v 3., 9., 21. in 24. mesecu.
English: Acute phase reaction, pain
Slovenian: reakcija akutne faze, bolečina
English: It is used:
Slovenian: Uporabljamo jo za:
English: Age, body weight, gender and creatinine clearance appear to have no effect on zoledronic acid systemic exposure.
Slovenian: Kaže, da starost, telesna masa, spol in očistek kreatinina ne vplivajo na sistemsko izpostavljenost zoledronski kislini.
English: These transverse or short oblique fractures can occur anywhere along the femur from just below the lesser trochanter to just above the supracondylar flare.
Slovenian: Ti prečni ali kratki poševni zlomi se lahko pojavljajo kjerkoli na stegnenici, od mesta tik pod malim trohanterjem do tik nad suprakondilarno grčo.
English: A kidney function disorder called Fanconi syndrome (will normally be determined by your doctor with certain urine tests).
Slovenian: okvara v delovanju ledvic, imenovana Fanconijev sindrom (običajno jo ugotovi zdravnik s pomočjo določenih preiskav urina).
English: * Includes vertebral and non-vertebral fractures ** Accounts for all skeletal events, the total number as well as time to each event during the trial NR Not Reached
Slovenian: * zajema vertebralne in nevertebralne zlome; ** velja za vse skeletne dogodke, tako za njihovo celotno število kot za trajanje vsakega dogodka med preskušanjem;
English: Tumours can accelerate normal bone change in such a way that the release of calcium from bone is increased.
Slovenian: Tumorji lahko pospešijo normalno spreminjanje kosti, tako da se poveča sproščanje kalcija iz kosti.
English: Tell your doctor about any of the following serious side effects straight away:
Slovenian: Takoj povejte zdravniku, če imate katerega od naslednjih resnih neželenih učinkov:
English: Although no teratogenicity or foetotoxicity was observed in the rabbit, maternal toxicity was found.
Slovenian: Čeprav pri kuncu niso opazili teratogenosti ali fetotoksičnosti, je bila ugotovljena toksičnost za mater.
English: In addition to being a potent inhibitor of bone resorption, zoledronic acid also possesses several antitumour properties that could contribute to its overall efficacy in the treatment of metastatic bone disease.
Slovenian: Poleg tega, da je zoledronska kislina močan inhibitor resorpcije kosti, ima tudi več protitumorskih lastnosti, ki bi lahko prispevale k njeni celotni učinkovitosti v zdravljenju metastatične bolezni kosti.
English: In long-term animal studies, zoledronic acid inhibits bone resorption without adversely affecting the formation, mineralisation or mechanical properties of bone.
Slovenian: V dolgoročnih raziskavah na živalih zoledronska kislina zavira resorpcijo kosti, ne da bi neugodno vplivala na oblikovanje, mineralizacijo ali mehanske lastnosti kosti.
English: For patients requiring dental procedures, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of osteonecrosis of the jaw.
Slovenian: Glede bolnikov, pri katerih so potrebni zobozdravstveni postopki, ni na voljo nikakršnih podatkov, ki bi kazali na to, ali prekinitev difosfonatnega zdravljenja zmanjša tveganje za osteonekrozo čeljustnic.
English: How much Zometa is given - The usual single dose given is 4 mg. - If you have a kidney problem, your doctor will give you a lower dose depending on the severity of your kidney problem.
Slovenian: Koliko zdravila Zometa se daje - Običajni posamezni odmerek je 4 mg. - Če imate težave z ledvicami, vam bo zdravnik dal manjši odmerek, ki bo odvisen od tega, kako hude so vaše težave z ledvicami.
English: The most frequent finding in repeat-dose studies consisted of increased primary spongiosa in the metaphyses of long bones in growing animals at nearly all doses, a finding that reflected the compound's pharmacological antiresorptive activity.
Slovenian: Najpogostejša ugotovitev v študijah večkratnih odmerkov je bilo zvečanje primarne spongiozne kostne substance v metafizah dolgih kosti pri rastočih živalih pri skoraj vseh odmerkih; ta ugotovitev odseva farmakološki antiresorpcijski učinek zdravila.
English: Increasing the infusion time from 5 to 15 minutes caused a 30% decrease in zoledronic acid concentration at the end of the infusion, but had no effect on the area under the plasma concentration versus time curve.
Slovenian: Podaljšanje časa infundiranja s 5 na 15 minut je povzročilo 30-odstotno znižanje koncentracije zoledronske kisline ob koncu infuzije, ni pa vplivalo na površino pod krivuljo plazemske koncentracije proti času.
English: The selective action of bisphosphonates on bone is based on their high affinity for mineralised bone, but the precise molecular mechanism leading to the inhibition of osteoclastic activity is still unclear.
Slovenian: Selektivno delovanje difosfonatov na kost temelji na njihovi veliki afiniteti do mineralizirane kosti, vendar je natančen molekularni mehanizem, ki privede do inhibicije osteoklastne aktivnosti, še nejasen.
English: Clinical experience with acute overdose of Zometa is limited.
Slovenian: Klinične izkušnje z akutnim prevelikim odmerjanjem zdravila Zometa so omejene.
English: Date of first authorisation: 20.03.2001 Date of latest renewal: 20.03.2006
Slovenian: Datum prve odobritve: 20. marec 2001 Datum zadnjega podaljšanja: 20. marec 2006
English: Possible risk factors for osteonecrosis of the external auditory canal include steroid use and chemotherapy and/or local risk factors such as infection or trauma.
Slovenian: Med možne dejavnike tveganja za osteonekrozo zunanjega slušnega kanala spadajo uporaba steroidov in kemoterapija in/ali lokalni dejavniki tveganja, kot sta okužba in poškodba.
English: How often Zometa is given - If you are being treated for the prevention of bone complications due to bone metastases, you will be given one infusion of Zometa every three to four weeks.
Slovenian: Kako pogosto se daje zdravilo Zometa - Če prejemate zdravilo za preprečevanje zapletov na kosteh zaradi kostnih metastaz, boste prejeli eno infuzijo zdravila Zometa vsake tri do štiri tedne.
English: *Doses have been calculated assuming target AUC of 0.66 (mg•hr/l) (CLcr = 75 ml/min).
Slovenian: *Odmerki so preračunani s predpostavko, da je ciljna AUC 0,66 (mg•h/l) (za CLcr=75 ml/min).
English: Cases of severe hypocalcaemia requiring hospitalisation have been reported.
Slovenian: Poročali so tudi o primerih hude hipokalciemije, zaradi katere je bilo treba bolnika hospitalizirati.
English: Acute phase reaction
Slovenian: Reakcija akutne faze
English: The SRE rate (events/person year) was 0.628 for zoledronic acid and 1.096 for placebo.
Slovenian: Pogostnost SRE (dogodki/osebe-leta) je bila 0,628 z zoledronsko kislino in 1,096 s placebom.
English: • Hypersensitivity to the active substance, to other bisphosphonates or to any of the excipients listed in section 6.1.
Slovenian: • Preobčutljivost na učinkovino, na druge difosfonate ali katero koli pomožno snov, navedeno v poglavju 6.1.
English: If hypocalcaemia, hypophosphataemia, or hypomagnesaemia occurs, short-term supplemental therapy may be necessary.
Slovenian: Če nastopi hipokalciemija, hipofosfatemija ali hipomagneziemija, moramo uvesti kratkoročno dopolnilno zdravljenje.
English: Patients received either 4 mg zoledronic acid or placebo every four weeks for one year.
Slovenian: Bolnice so v obdobju enega leta prejemale bodisi 4 mg zoledronske kisline bodisi placebo vsake štiri tedne.
English: Date of first authorisation: 24.03.2003 Date of latest renewal: 20.03.2006
Slovenian: Datum prve odobritve: 24. marec 2003 Datum zadnjega podaljšanja: 20. marec 2006
English: It is not known whether zoledronic acid is excreted into human milk.
Slovenian: Ni znano, ali se zoledronska kislina izloča v materino mleko.
English: Zoledronic acid was not mutagenic in the mutagenicity tests performed and carcinogenicity testing did not provide any evidence of carcinogenic potential.
Slovenian: V opravljenih testih mutagenosti zoledronska kislina ni bila mutagena, testiranje kancerogenosti pa ni dalo nikakršnih dokazov o kancerogenem potencialu.
English: Children and adolescents Zometa is not recommended for use in adolescents and children below the age of 18 years.
Slovenian: Otroci in mladostniki Pri otrocih in mladostnikih, ki so stari manj kot 18 let, uporaba zdravila Zometa ni priporočena.
English: Healthcare professionals are advised not to dispose of unused Zometa via the domestic sewage system.
Slovenian: Zdravstvenim delavcem svetujemo, da neporabljenega zdravila Zometa ne izlijejo v gospodinjske odplake.
English: Use immediately after reconstitution and dilution.
Slovenian: Uporabite takoj po rekonstituciji in redčenju.
English: • Breast-feeding (see section 4.6).
Slovenian: • Dojenje (glejte poglavje 4.6).
English: Zometa should not be used during pregnancy.
Slovenian: Zdravila Zometa ne smete uporabljati med nosečnostjo.
English: Following initiation of therapy, serum creatinine should be measured prior to each dose of Zometa and treatment should be withheld if renal function has deteriorated.
Slovenian: Po uvedbi terapije je treba izmeriti serumski kreatinin pred vsakim odmerkom zdravila Zometa, terapijo pa je treba prekiniti, če se je ledvična funkcija poslabšala.
English: Limited pharmacokinetic data in children with severe osteogenesis imperfecta suggest that zoledronic acid pharmacokinetics in children aged 3 to 17 years are similar to those in adults at a similar mg/kg dose level.
Slovenian: Majhno število podatkov o farmakokinetiki pri bolnikih s hudo obliko osteogenesis imperfecta kaže, da so farmakokinetične lastnosti zoledronske kisline pri otrocih v starosti od 3 do 17 let podobne tistim pri odraslih pri enakovredni ravni odmerjanja v mg/kg.
English: While being treated with Zometa, you should maintain good oral hygiene (including regular teeth brushing) and receive routine dental check-ups.
Slovenian: V času zdravljenja z zdravilom Zometa morate skrbeti za dobro ustno higieno (kar vključuje redno čiščenje zob) in redno hoditi na rutinske preglede k zobozdravniku.
English: The type of adverse reactions observed in this population were similar to those previously seen in adults with advanced malignancies involving the bone (see section 4.8).
Slovenian: Vrste neželenih dogodkov, ki so jih opažali v tej populaciji, so bile večinoma podobne tistim, ki so jih prej opažali pri odraslih z napredovalimi malignimi boleznimi, ki zajamejo kosti (glejte poglavje 4.8).
English: Clinical trial results in the treatment of severe osteogenesis imperfecta in paediatric patients aged 1 to 17 years
Slovenian: Rezultati kliničnih preskušanj zdravljenja hude oblike osteogenesis imperfecta pri pediatričnih bolnikih, starih od 1 leta do 17 let
English: Adverse reactions, such as dizziness and somnolence, may have influence on the ability to drive or use machines, therefore caution should be exercised with the use of Zometa along with driving and operating of machinery.
Slovenian: Neželeni učinki, kot na primer vrtoglavost in somnolenca, lahko vplivajo na sposobnost vožnje in upravljanja strojev, zato je ob uporabi zdravila Zometa potrebna previdnost pri vožnji in upravljanju strojev.
English: The highest non-lethal single intravenous dose was 10 mg/kg bodyweight in mice and 0.6 mg/kg in rats.
Slovenian: Največji neletalni posamezni intravenski odmerek je bil 10 mg/kg telesne mase pri miših in 0,6 mg/kg pri podganah.
English: - Treatment of adult patients with tumour-induced hypercalcaemia (TIH).
Slovenian: - Zdravljenje odraslih bolnikov s tumorsko povzročeno hiperkalciemijo (TIH).
English: Furthermore, there is evidence of an association between hypocalcaemia and secondary neurological events reported in these cases including; convulsions, hypoaesthesia and tetany (see section 4.4).
Slovenian: Poleg tega obstajajo dokazi o povezanosti hipokalciemije in posledičnih nevroloških dogodkov, o katerih so poročali v teh primerih in so vključevali konvulzije, hipestezijo in tetanijo (glejte poglavje 4.4).
English: The possibility of osteonecrosis of the external auditory canal should be considered in patients receiving bisphosphonates who present with ear symptoms including chronic ear infections.
Slovenian: Možnost osteonekroze zunanjega slušnega kanala je treba upoštevati pri bolnikih, ki prejemajo bisfosfonate in pri katerih se pojavljajo simptomi bolezni ušesa, vključno s kroničnimi vnetji ušesa.
English: Confusion
Slovenian: zmedenost
English: How Zometa is used
Slovenian: Kako se zdravilo Zometa uporablja
English: Untreated hypercalcaemia patients generally have some degree of renal function impairment, therefore careful renal function monitoring should be considered.
Slovenian: Bolniki z nezdravljeno hiperkalciemijo imajo na splošno bolj ali manj izraženo okvaro delovanja ledvic, zato moramo razmisliti o skrbnem spremljanju ledvične funkcije.