FrancophonIA/ELRC3.0 huggingface dataset:
English: Intensified Monitoring:
Slovenian: Intenzivno spremljanje
English: If you or your patient take more Epidyolex than you should If you may have taken more Epidyolex than you should, tell a doctor or pharmacist immediately, or contact your nearest hospital casualty department, and take the medicine with you.
Slovenian: Če ste vi ali vaš bolnik vzeli večji odmerek zdravila Epidyolex, kot bi smeli Če ste vzeli večji odmerek zdravila Epidyolex, kot bi smeli, o tem takoj obvestite svojega zdravnika ali farmacevta, ali pa pojdite na urgentni oddelek najbližje bolnišnice in s seboj prinesite zdravilo.
English: The interactions are summarised in the table below.
Slovenian: Interakcije so povzete v spodnji preglednici.
English: As a precautionary measure, cannabidiol should not be used during pregnancy unless the potential benefit to the mother clearly outweighs the potential risk to the foetus.
Slovenian: Iz previdnostnih razlogov se med nosečnostjo kanabidiol ne sme uporabljati, razen če pričakovana korist za mater nedvomno odtehta morebitno tveganje za plod.
English: The most frequent cause of discontinuations was transaminase elevation.
Slovenian: Najpogostejši vzrok prekinitve zdravljenja je bil zvišanje transaminaz.
English: Your doctor may do blood tests to check your liver before you start taking this medicine and during treatment, as Epidyolex can cause liver problems.
Slovenian: Zdravnik bo morda opravil krvne preiskave, da preveri delovanje jeter, preden začnete jemati to zdravilo ali med samim zdravljenjem, saj lahko zdravilo Epidyolex povzroči težave z jetri.
English: The following side effects could be very serious:
Slovenian: Spodaj navedeni neželeni učinki so lahko zelo resni.
English: Cannabidiol does not exert its anticonvulsant effect through interaction with cannabinoid receptors.
Slovenian: Kanabidiol svojega antikonvulzivnega učinka ne doseže na podlagi medsebojnega delovanja s kanabinoidnimi receptorji.
English: Juvenile toxicity
Slovenian: Toksičnost za mladiče
English: Table 1: Dose adjustments in patients with moderate or severe hepatic impairment
Slovenian: Preglednica 1: Prilagoditve odmerka pri bolnikih z zmerno ali hudo okvaro jeter
English: Increases in creatinine
Slovenian: Zvišanje kreatinina
English: Continuous weight loss/absence of weight gain should be periodically checked to evaluate if cannabidiol treatment should be continued.
Slovenian: Kontinuirano izgubo telesne mase/nepridobivanje telesne mase je treba redno preverjati in oceniti, ali lahko zdravljenje s kanabidiolom nadaljujemo.
English: Across both randomised LGS studies, 99.5% of patients who completed the studies were enrolled into the long-term open-label extension study (GWPCARE5).
Slovenian: V obeh randomiziranih študijah LGS je bilo 99,5 % bolnikov, ki so zaključili študijo, vključenih v dolgoročno odprto podaljšano študijo (GWPCARE5).
English: Clobazam (separate analysis) was a significant covariate which caused the probability of GGT to increase, loss of appetite to decrease, and somnolence to increase.
Slovenian: Klobazam (ločena analiza) je bil pomembna sospremenljivka, ki je povzročila večjo verjetnost povečanja GGT, zmanjšanja apetita in povečanja zaspanosti.
English: PK/PD analysis also demonstrated that systemic exposures to cannabidiol were correlated with some adverse events namely elevated ALT, AST, diarrhoea, fatigue, GGT, loss of appetite, rash, and somnolence (see section 4.8).
Slovenian: Analiza FK/FD je pokazala tudi, da so bile sistemske izpostavljenosti kanabidiolu povezane z nekaterimi neželenimi učinki, in sicer zvišanima ALT in AST, drisko, utrujenostjo, GGT, izgubo apetita, izpuščajem in zaspanostjo (glejte poglavje 4.8).
English: Slowly pull back the plunger of the syringe, so the volume (number of ml) of solution needed is drawn into the syringe.
Slovenian: Bat brizge počasi povlecite nazaj, tako da v brizgo potegnete potrebno količino (število mililitrov) raztopine.
English: Across both randomised DS studies, 97.7% of patients who completed the studies were enrolled into GWPCARE5.
Slovenian: V obeh randomiziranih študijah LGS je bilo 97,7 % bolnikov, ki so zaključili študijo, vključenih v študijo GWPCARE5.
English: Concomitant use of cannabidiol and valproate increases the incidence of diarrhoea and events of decreased appetite.
Slovenian: Sočasna uporaba kanabidiola in valproata poveča incidenco diareje in zmanjšanja apetita.
English: Mean age of the study population was 9 years and 94% were taking 2 or more cAEDs during the trial.
Slovenian: Starost študijske populacije je bila v povprečju 9 let, 94 % bolnikov pa je med preskušanjem sočasno jemalo 2 ali več vrst cAED.
English: You should not drive, use machines or take part in activities that require you to be alert and have fine control, until it is established that your ability to perform such activities is not affected.
Slovenian: Ne vozite, ne upravljajte strojev in ne opravljajte dejavnosti, ki zahtevajo vašo pozornost in dober nadzor, dokler ni potrjeno, da zdravilo ne vpliva na vašo sposobnost izvajanja teh dejavnosti.
English: Less than 1% of cannabidiol-treated patients had ALT or AST levels greater than 20 times the ULN.
Slovenian: Manj kot 1 % bolnikov, zdravljenih s kanabidiolom, je imelo vrednosti ALT ali AST zvišane nad 20-kratno ZMN.
English: In an uncontrolled study in patients in a different non-epilepsy indication, 2 elderly patients experienced elevations of alkaline phosphatase levels above 2 times the ULN in combination with transaminase elevations.
Slovenian: V nekontrolirani študiji, opravljeni pri bolnikih z drugačno indikacijo, ki ni povezana z epilepsijo, sta imela 2 starejša bolnika zvišane vrednosti alkalne fosfataze nad 2-kratno ZMN in hkrati zvišane vrednosti transaminaz.
English: Line up the end of the plunger with the volume marking required, as shown opposite.
Slovenian: Konec bata poravnajte z ustrezno oznako za količino, kot je prikazano na sliki na nasprotni strani.
English: Always take Epidyolex according to your doctor's instructions and consistently either with or without food including high-fat meals (such as ketogenic diet).
Slovenian: Zdravilo Epidyolex vedno jemljite v skladu z zdravnikovimi navodili in dosledno bodisi s hrano ali brez nje, vključno z obroki z veliko maščobe (npr. pri ketogeni dieti).
English: Your doctor or pharmacist will let you know which syringe to use depending on the dose that has been prescribed.
Slovenian: Zdravnik ali farmacevt vam bo glede na odmerek, ki vam je bil predpisan, povedal, katero brizgo morate uporabiti.
English: If the dose is more than 5 ml, repeat Steps 4 to 7 to give the remaining dose using the 5 ml oral syringe.
Slovenian: Če odmerek znaša več kot 5 ml, s pomočjo 5-mililitrske brizge ponovite korake od 4 do 7, da aplicirate preostalo količino odmerka.
English: Common side effects (may affect more than 1 in 100 people):
Slovenian: Pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 100 bolnikov):
English: Concomitant Valproate and Clobazam
Slovenian: Sočasna uporaba valproata in klobazama
English: A meta-analysis of randomised placebo-controlled trials with AEDs has shown a small increased risk of suicidal behaviour and ideation.
Slovenian: Metaanaliza randomiziranih, s placebom kontroliranih kliničnih preskušanj AED je pokazala majhno povečanje tveganja za pojav samomorilnega vedenja in razmišljanja.
English: Effect of age, weight, sex, race
Slovenian: Vpliv starosti, telesne mase, spola in rase
English: If you have these thoughts at any time, contact your doctor
Slovenian: Če imate kadar koli takšne misli, se posvetujte z zdravnikom.
English: Population pharmacokinetic analyses demonstrated that there were no clinically relevant effects of age, body weight, sex, or race on exposure to cannabidiol.
Slovenian: Analize populacijske farmakokinetike so pokazale, da starost, telesna masa, spol ali rasa nimajo klinično pomembnega vpliva na izpostavljenost kanabidiolu.
English: Convulsive seizures were defined as atonic, tonic, clonic, and tonic-clonic seizures.
Slovenian: Konvulzivni napadi so bili opredeljeni kot atonični, tonični, klonični in tonično-klonični epileptični napadi.
English: When cannabidiol was combined with stiripentol there was a minor increase in stiripentol levels of 28% for Cmax and 55% for AUC.
Slovenian: Pri uporabi kanabidiola v kombinaciji s stiripentolom je prišlo do majhnega povečanja Cmax koncentracije stiripentola za 28 % in AUC za 55 %.
English: You should not take Epidyolex while you are pregnant unless the doctor decides the benefits outweigh the potential risks.
Slovenian: Med nosečnostjo zdravila Epidyolex ne bi smeli jemati, razen če je zdravnik odločil, da prednosti zdravljenja pretehtajo potencialne nevarnosti.
English: Each ml of Epidyolex contains 79 mg of ethanol.
Slovenian: En ml zdravila Epidyolex vsebuje 79 mg etanola.
English: In controlled studies in healthy adults and in patients with LGS and DS, an increase in serum creatinine of approximately 10% was observed within 2 weeks of starting cannabidiol.
Slovenian: V kontroliranih študijah, opravljenih pri zdravih odraslih in pri bolnikih z LGS in DS, so v 2 tednih od začetka zdravljenja s kanabidiolom opazili zvišanje serumskega kreatinina za približno 10 %.
English: For an adult weighing 70 kg, this is equivalent to 14 millilitres (ml) of beer, or 6 ml of wine per dose.
Slovenian: To pri odraslem s telesno maso 70 kg ustreza 14 mililitrom (ml) piva ali 6 ml vina na odmerek.
English: A slower or faster down titration may be required, as clinically indicated, at the discretion of the prescriber.
Slovenian: Morda bo potrebno počasnejše ali hitrejše zmanjševanje odmerka, kot je to klinično indicirano, o čemer presodi zdravnik, ki zdravilo predpiše.
English: Food may increase cannabidiol levels and therefore it should be taken consistently either with or without food, including the ketogenic diet (see section 5.2).
Slovenian: Hrana lahko poveča koncentracije kanabidiola, zato je treba zdravilo jemati dosledno s hrano ali brez nje,, vključno s ketogeno dieto (glejte poglavje 5.2).
English: Cannabidiol reduces neuronal hyper-excitability through modulation of intracellular calcium via G protein-coupled receptor 55 (GPR55) and transient receptor potential vanilloid 1 (TRPV-1) channels, as well as modulation of adenosine-mediated signalling through inhibition of adenosine cellular uptake via the equilibrative nucleoside transporter 1 (ENT-1).
Slovenian: Kanabidiol zmanjša hiperekscitabilnost živcev z modulacijo znotrajceličnega kalcija preko z G-proteinom sklopljenega receptorja 55 (GPR55 - G protein-coupled receptor 55) in kanalčkov vaniloidnega receptorja 1 (TRPV1 - transient receptor potential vanilloid 1) ter z modulacijo adenozinsko posredovanega signaliziranja, tako da zavira celični privzem adenozina preko ekvilibracijskega nukleozidnega prenašalca 1 (ENT1).
English: In vitro assessment of drug interactions
Slovenian: In vitro ocena medsebojnega delovanja zdravil
English: After single dosing, exposure over the range 750-6000 mg increases in a less than dose-proportional manner, indicating that absorption of cannabidiol may be saturable.
Slovenian: V mejah med 750 mg in 6.000 mg se po enkratnem odmerjanju izpostavljenost poveča manj kot sorazmerno odmerku, kar kaže na to, da absorpcija kanabidiola lahko poteka do zasičenja.
English: Paediatric population There is no relevant use of cannabidiol in children aged below 6 months.
Slovenian: Pediatrična populacija Kanabidiol ni namenjen za uporabo pri otrocih, starih manj kot 6 mesecev.
English: Very common side effects (may affect more than 1 in 10 people):
Slovenian: Zelo pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 10 bolnikov)
English: Each Epidyolex carton is supplied with:
Slovenian: Vsaka škatla z zdravilom Epidyolex vsebuje:
English: The occurrence was higher for those patients on concomitant clobazam (see sections 4.5 and 4.8).
Slovenian: Pojavnost je bila višja pri bolnikih, ki so sočasno prejemali klobazam (glejte poglavji 4.5 in 4.8).
English: Abuse
Slovenian: Zloraba
English: Do not start or stop other medicines without talking to your doctor or pharmacist.
Slovenian: Ne začnite jemati niti ne prenehajte jemati katerih koli zdravil, brez da bi se pred tem posvetovali z zdravnikom ali farmacevtom.
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children
Slovenian: POSEBNO OPOZORILO O SHRANJEVANJU ZDRAVILA ZUNAJ DOSEGA IN POGLEDA OTROK
English: Following the directions from the doctor or pharmacist, the bag containing the other syringes and adapter should be discarded from the pack unless your doctor or pharmacist tells you to keep both syringes until your final dose has been reached.
Slovenian: Vrečko z drugima dvema brizgama in nastavkom iz pakiranja je treba zavreči v skladu z navodili zdravnika ali farmacevta, razen če vam zdravnik ali farmacevt naroči, da obe brizgi shranite, dokler ne uporabite zadnjega odmerka.
English: No human data on the effect of cannabidiol on fertility are available.
Slovenian: Na voljo ni nobenih podatkov o vplivu kanabidiola na plodnost pri človeku.
English: - lack of energy - cold, sore throat - respiratory tract infections (pneumonia, bronchitis) - blood tests showing increases in levels of certain liver enzymes (which may be signs of liver damage) - shaking of the body or parts of it - feeling bad-tempered (irritable, aggressive) - difficulty in sleeping - cough - rash - increased appetite, weight loss - drooling - urinary tract infection - agitation - abnormal behaviour
Slovenian: - pomanjkanje energije - prehlad, vnetje žrela - okužbe dihal (pljučnica, bronhitis) - krvne preiskave, ki kažejo na povečane vrednosti nekaterih jetrnih encimov (kar je lahko znak okvare jeter) - tresenje telesa ali njegovih delov - slabo razpoloženje (razdražljivost, agresivnost) - težave s spanjem - kašelj - izpuščaj - povečan apetit, izguba telesne mase - slinjenje - okužba sečil - vznemirjenost - nenormalno vedenje
English: In clinical trials, the majority of ALT elevations occurred in patients taking concomitant valproate.
Slovenian: V kliničnih preskušanjih se je zvišanje vrednosti ALT večinoma pojavilo pri bolnikih, ki so sočasno jemali valproat.
English: No formal drug-drug interaction studies have been conducted with cannabidiol in combination with UGT inhibitors, therefore caution should be taken when co-administering drugs that are known inhibitors of these UGTs.
Slovenian: Formalnih študij medsebojnega delovanja s kanabidiolom v kombinaciji z zaviralci UGT ni bilo, zato je pri sočasni uporabi zdravil, ki so znani zaviralci teh encimov UGT, potrebna previdnost.
English: In about one-third of the cases, transaminase elevations resolved during continued treatment with cannabidiol, without dose reduction.
Slovenian: Pri približno eni tretjini bolnikov je zvišanje transaminaz izginilo med nadaljevanjem zdravljenja s kanabidiolom, brez zmanjšanja odmerka.
English: Talk to your doctor about driving, using machines or when children undertake activities such as cycling or other sports, because you may feel sleepy after taking this medicine.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Z zdravnikom se posvetujte glede vožnje, upravljanja strojev ali udeleževanja otrok pri dejavnostih, kot so kolesarjenje in druge športne aktivnosti, saj lahko to zdravilo povzroči občutek zaspanosti.
English: A small number of patients < 2 years with treatment-resistant epilepsy have been exposed to cannabidiol in an expanded access programme.
Slovenian: Manjše število bolnikov z epilepsijo, odporno proti zdravljenju, starih < 2 leti, so s kanabidiolom zdravili v okviru programa z razširjenim dostopom.
English: BATCH NUMBER, DONATION AND PRODUCT CODES Lot
Slovenian: ŠTEVILKA SERIJE, ENOTNE OZNAKE DAROVANJA IN IZDELKOV Lot
English: Pneumoniaa, Bronchitis, Nasopharyngitis, Urinary tract infection
Slovenian: Pljučnicaa, bronhitis, nazofaringitis, okužba sečil
English: In patients, there is a potential additive anticonvulsant effect from the bi-directional pharmacokinetic interaction between cannabidiol and clobazam, which leads to increases in circulating levels of their respective active metabolites, 7-OH-CBD (approximately 1.5-fold) and N-CLB (approximately 3-fold) (see sections 4.5, 5.1 and 5.2).
Slovenian: Pri bolnikih obstaja potencialni aditivni antikonvulzivni učinek zaradi dvosmernega farmakokinetičnega medsebojnega delovanja med kanabidiolom in klobazamom, kar vodi do povečanja koncentracij njunih aktivnih presnovkov v obtoku, 7-OH-CBD (za približno 1,5-krat) in N-CLB (za približno 3-krat) (glejte poglavji 4.5, 5.1 in 5.2).
English: In addition, there was an increased exposure to 7-hydroxy-cannabidiol (7-OH-CBD; an active metabolite of cannabidiol), for which plasma area under the curve (AUC) increased by 47% (see section 5.2).
Slovenian: Poleg tega je prišlo do povečane izpostavljenosti 7-hidroksikanabidiolu (7-OH-CBD; aktivni presnovek kanabidiola), za katerega se je površina pod krivuljo (AUC) plazemskih koncentracij povečala za 47 % (glejte poglavje 5.2).
English: If your liver is not working properly, your treatment may need to be stopped.
Slovenian: Če imate motnje delovanja jeter, bo zdravljenje morda treba prekiniti.
English: You should not breast-feed whilst taking Epidyolex, as Epidyolex is likely to be present in breast milk.
Slovenian: V času jemanja zdravila Epidyolex ne smete dojiti, saj se zdravilo Epidyolex lahko izloča v materino mleko.
English: Contact your doctor or go to a hospital straight away.
Slovenian: Nemudoma se posvetujte s svojim zdravnikom ali poiščite pomoč v najbližji bolnišnici.
English: Valproate
Slovenian: Valproat
English: Discard unused portion 8 weeks after first opening Date of first opening:
Slovenian: Neuporabljeno raztopino zavrzite 8 tednov po prvem odprtju.
English: Cannabidiol causes dose-related elevations of liver transaminases (alanine aminotransferase [ALT] and/or aspartate aminotransferase [AST]) (see section 4.8).
Slovenian: Kanabidiol povzroča od odmerka odvisno zvišanje jetrnih transaminaz (alanin-aminotransferaze [ALT] in/ali aspartat-aminotransferaze [AST]) (glejte poglavje 4.8).
English: 2 mg/kg twice daily (4 mg/kg/day)* *Higher doses of cannabidiol may be considered in patients with severe hepatic impairment where the potential benefits outweigh the risks.
Slovenian: 2 mg/kg dvakrat na dan (4 mg/kg/dan)* *Pri bolnikih s hudo okvaro jeter, pri katerih so možne koristi večje od tveganj, se sme razmisliti o večjih odmerkih kanabidiola.
English: Patients with transaminase elevations greater than 3 times the upper limit of normal (ULN) and bilirubin greater than 2 times the ULN (see section 4.4).
Slovenian: Pri bolnikih s povišanjem transaminaz nad 3-kratno zgornjo mejo normalnih vrednosti (ZMN) in bilirubinom, ki je več kot 2-krat večji od ZMN (glejte poglavje 4.4).
English: Mean age of the study population was 15 years and 94% were taking 2 or more concomitant AEDs (cAEDs) during the trial.
Slovenian: Starost študijske populacije je bila v povprečju 15 let, 94 % bolnikov pa je med preskušanjem sočasno jemalo 2 ali več vrst AED (cAEDconcomitant AED).
English: Frequency Adverse reactions from clinical trials
Slovenian: Neželeni učinki iz kliničnih preskušanj
English: Adverse reactions reported with cannabidiol in placebo-controlled clinical studies are listed in the table below by System Organ Class and frequency.
Slovenian: Neželeni učinki, o katerih so poročali pri uporabi kanabidiola v kliničnih študijah, kontroliranih s placebom, so glede na organski sistem in pogostnost navedeni v spodnji preglednici.
English: Cannabidiol can cause elevations in serum creatinine.
Slovenian: Kanabidiol lahko povzroči zvišanje serumskega kreatinina.
English: Epidyolex contains cannabidiol, a medicine which can be used to treat epilepsy, a condition where someone has seizures or fits.
Slovenian: Epidyolex vsebuje kanabidiol, ki se lahko uporablja za zdravljenje epilepsije oziroma bolezni, pri kateri ima oseba epileptične napade ali krče.
English: If clinically significant increases of transaminases occur, cannabidiol and/or concomitant valproate should be reduced or discontinued in all patients until a recovery of transaminase elevations are observed (see section 4.4).
Slovenian: Če pride do klinično pomembnega povečanja transaminaz, je treba pri vseh bolnikih uporabo kanabidiola in/ali sočasno uporabljanega valproata zmanjšati ali prekiniti, dokler ni ugotovljeno izboljšanje zvišanih vrednosti transaminaz (glejte poglavje 4.4).
English: Dose adjustments of other medicinal products used in combination with cannabidiol A physician experienced in treating patients who are on concomitant antiepileptic drugs (AEDs) should evaluate the need for dose adjustments of cannabidiol or of the concomitant medicinal product(s) to manage potential drug interactions (see sections 4.4 and 4.5).
Slovenian: Prilagoditve odmerkov drugih zdravil, ki se uporabljajo sočasno s kanabidiolom Zdravnik, ki ima izkušnje z zdravljenjem bolnikov s sočasnim zdravljenjem z antiepileptičnimi zdravili (AED - antiepileptic drugs), mora oceniti potrebo po prilagoditvi odmerka kanabidiola ali sočasno uporabljenega(ih) zdravil(a) za obvladovanje možnih interakcij med zdravili (glejte poglavji 4.4 in 4.5).
English: Twenty-seven percent (27%) of cannabidiol-treated patients developed a new laboratory-defined anaemia during the course of the study (defined as a normal haemoglobin concentration at baseline, with a reported value less than the lower limit of normal at a subsequent time point).
Slovenian: V času trajanja študije je sedemindvajset (27 %) odstotkov bolnikov, zdravljenih s kanabidiolom, razvilo novo, laboratorijsko opredeljeno anemijo (opredeljeno kot normalno koncentracijo hemoglobina ob izhodišču, ob naslednji časovni točki pa so poročali o vrednosti pod spodnjo mejo normale).
English: The lowest dose causing developmental toxicity in juvenile rats (15 mg/kg subcutaneous/100 mg/kg oral) was associated with Cmax cannabidiol exposures approximately 20 times that in paediatric subjects at 20 mg/kg/day.
Slovenian: Najmanjši odmerek, ki je povzročil razvojno toksičnost pri mladih podganah (15 mg/kg subkutano/100 mg/kg peroralno) je bil povezan s Cmax izpostavljenostjo kanabidiolu, ki je bila približno 20-krat večja kot izpostavljenost pri pediatričnih bolnikih pri 20 mg/kg/dan.
English: Epidyolex is an oral solution (a liquid to be swallowed).
Slovenian: Zdravilo Epidyolex je peroralna raztopina (tekočina, ki jo je treba pogoltniti).
English: The most common adverse reactions are somnolence, decreased appetite, diarrhoea, pyrexia, fatigue, and vomiting.
Slovenian: Najpogostejši neželeni učinki so somnolenca, zmanjšan apetit, diareja, pireksija, utrujenost in bruhanje.
English: The responder rate analysis also showed a correlation in the exposure-response relationship for the active metabolite of cannabidiol (7-OH-CBD).
Slovenian: Analiza deleža odzivnih bolnikov je pokazala tudi korelacijo med izpostavljenostjo in odzivom za aktivni presnovek kanabidiola (7-OH-CBD).
English: The key secondary endpoint for GWPCARE1 was the proportion of patients with at least a 50% reduction in convulsive seizure frequency.
Slovenian: Ključno sekundarno merilo v okviru študije GWPCARE1 je bilo delež bolnikov z vsaj 50-odstotnim zmanjšanjem pogostnosti konvulzivnih napadov.
English: Cannabidiol and the metabolite 7-OH-CBD do not interact with the major renal or hepatic uptake transporters and therefore are unlikely to result in relevant drug-drug interactions: OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1B1and OATP1B3.
Slovenian: Kanabidiol in presnovek 7-OH-CBD ne vplivata na glavne ledvične in jetrne privzemne prenašalce, zato je malo verjetno, da povzročita pomembne interakcije z drugimi zdravili: OAT1, OAT3, OCT1, OCT2, MATE1, MATE2K, OATP1B1 in OATP1B3.
English: Make sure the oral syringe is completely dry before the next use, or it could make the solution appear cloudy if water gets in the bottle.
Slovenian: Pred naslednjo uporabo se prepričajte, da je brizga za peroralno dajanje popolnoma suha, saj je raztopina lahko videti motna, če vanjo zaide voda.