FrancophonIA/ELRC3.0 huggingface dataset:
English: Recommendation concerning co-administration with efavirenz gabapentin are exclusively eliminated unchanged in the urine and are unlikely to compete for the same metabolic enzymes and elimination pathways as efavirenz.
Slovenian: saj se vigabatrin in gabapentin izločata izključno z urinom v nespremenjeni obliki ter ni verjetno, da bi prišlo do kompeticije za iste presnovne encime in poti izločanja kot pri efavirenzu.
English: Efavirenz concentrations not measured, no effect is expected.
Slovenian: Koncentracij efavirenza niso izmerili.
English: Protease inhibitor : Elbasvir/grazoprevir
Slovenian: infibitor proteaze: elbasvir/grazoprevir
English: maraviroc - the combination tablet containing efavirenz, emtricitabine, and tenofovir should not be taken with Efavirenz Teva unless recommended by your doctor since it contains efavirenz, the active ingredient of Efavirenz Teva.
Slovenian: kombinirane tablete, ki vsebujejo kombinacijo efavirenza, emtricitabina in tenofovirja, ne smete jemati skupaj z zdravilom Efavirenz Teva, razen če vam je tako svetoval zdravnik, ker vsebuje efavirenz, ki je učinkovina v zdravilu Efavirenz Teva.
English: (500/125 mg twice daily/ 600 mg once daily)
Slovenian: (500/125 mg dvakrat na dan/600 mg enkrat na dan)
English: In HIV infected patients at steady-state, mean Cmax, mean Cmin, and mean AUC were linear with 200 mg, 400 mg, and 600 mg daily doses.
Slovenian: Pri bolnikih, okuženih s HIV, so bile povprečna Cmax, povprečna Cmin in povprečna AUC v stanju dinamičnega ravnovesja linearno odvisne od dnevnega 200 mg, 400 mg in 600 mg odmerka.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral agents have a higher risk for severe and potentially life-threatening liver problems.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki se zdravijo s kombinacijo protiretrovirusnih učinkovin, obstaja večje tveganje za resne in lahko življenjsko nevarne težave z jetri.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR BLISTER PACK CONTAINING OF <30><30x1><90><90 x 1> EFAVIRENZ TEVA 600 mg FILM-COATED TABLETS
Slovenian: PODATKI NA ZUNANJI OVOJNINI ŠKATLA (pretisni omot vsebuje <30> <30x1> <90> <90x1> tablet) Efavirenz Teva 600 mg filmsko obložene tablete
English: This loss is due to significant decreases in elbasvir and grazoprevir plasma concentrations caused by CYP3A4 induction.
Slovenian: Do te izgube pride zaradi pomembnega zmanjšanja plazemske koncentracije elbasvira in grazoprevira, ki ga povzroči indukcija CYP3A4.
English: Pregnancies have occurred in women taking Efavirenz Teva while using a contraceptive implant, although it has not been established that the Efavirenz Teva therapy caused the contraceptive to fail.
Slovenian: Nekatere ženske, ki so med uporabo kontracepcijskega vsadka jemale zdravilo Efavirenz Teva, so zanosile, kljub temu da ni bilo dokazano, da zdravljenje z zdravilom Efavirenz Teva prepreči delovanje kontraceptiva.
English: If you take more Efavirenz Teva than you should
Slovenian: Če ste vzeli večji odmerek zdravila Efavirenz Teva, kot bi smeli
English: If you forget to take Efavirenz Teva
Slovenian: Če ste pozabili vzeti zdravilo Efavirenz Teva
English: Cross-resistance
Slovenian: Navzkrižna rezistenca
English: When taken with rifampicin in patients weighing 50 kg or greater, increasing efavirenz daily dose to 800 mg may provide exposure similar to a daily dose of 600 mg when taken without rifampicin.
Slovenian: Pri bolnikih s telesno maso 50 kg ali več je pri jemanju z rifampicinom je pri povečanju dnevnega odmerka efavirenza na 800 mg izpostavitev podobna kot pri dnevnem odmerku 600 mg, če bolnik ne jemlje rifampicina.
English: Malformations were observed in 3 of 20 foetuses/newborns from efavirenz-treated cynomolgus monkeys given doses resulting in plasma efavirenz concentrations similar to those seen in humans.
Slovenian: 20 zarodkov/mladičev opic vrste Cynomolgus, ki so bile zdravljene z efavirenzem v odmerkih, s katerimi so dosegli plazemske koncentracije efavirenza, ki so podobne tistim pri človeku.
English: If you had a rash while taking another NNRTI, you may be at a higher risk of getting a rash with Efavirenz Teva.
Slovenian: Če ste imeli izpuščaj med jemanjem drugega NNRTI, je pri vas večja možnost pojava izpuščaja zaradi zdravila Efavirenz Teva.
English: If efavirenz is co-administered with voriconazole, the voriconazole maintenance dose must be increased to 400 mg every 12 hours and the efavirenz dose must be reduced by 50%, i.e. to 300 mg once daily.
Slovenian: Če se zdravilo efavirenz uporablja sočasno z vorikonazolom, je treba vzdrževalni odmerek vorikonazola povečati na 400 mg na vsakih 12 ur, odmerek zdravila efavirenz pa zmanjšati za 50 %, to je na 300 mg enkrat na dan.
English: One hundred two patients 3 months to 16 years of age (median 5.7 years) were treated with efavirenz.
Slovenian: Z efavirenzem sta se zdravila sto dva bolnika, stara od 3 mesecev do 16 let (mediana 5,7 leta).
English: Among co-infected patients in study 006, elevations in AST to greater than five times ULN developed in 13% of efavirenz-treated patients and in 7% of control, and elevations in ALT to greater than five times ULN developed in 20% and 7%, respectively.
Slovenian: Med sočasno okuženimi bolniki v študiji 006 je prišlo do zvišanj AST, večjih od petkratne ZMN, pri 13 % bolnikov, zdravljenih z efavirenzem, in pri 7 % bolnikov v kontrolni skupini, ter do zvišanj ALT, večjih od petkratne ZMN,
English: MANUFACTURER RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Slovenian: B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z
English: When efavirenz is co-administered with an anticonvulsant that is a substrate of CYP450 isoenzymes, periodic monitoring of anticonvulsant levels should be conducted.
Slovenian: Ob sočasni uporabi efavirenza in antikonvulziva, ki je substrat izoencimov CYP450, je treba periodično nadzorovati koncentracije antikonvulzivov.
English: Reported rates of recurrent rash following a switch from nevirapine to efavirenz therapy, primarily based on retrospective cohort data from published literature, range from 13 to 18%, comparable to the rate observed in patients treated with efavirenz in clinical studies (see section 4.4).
Slovenian: Delež ponovitev izpuščaja po zamenjavi zdravljenja z nevirapinom z zdravljenjem z efavirenzem, o katerem so poročali in ki temelji na podatkih iz retrospektivnih kohortnih študij iz objavljene literature, znaša od 13 do 18 %, kar je primerljivo z deležem, ki so ga opazili pri bolnikih,
English: - abnormal dreams, difficulty concentrating, dizziness, headache, difficulty sleeping, drowsiness,
Slovenian: - nenormalne sanje, težave s koncentracijo, omotica, glavobol, oteženo spanje, zaspanost, težave s koordinacijo ali z ravnotežjem
English: Total active HMG CoA reductase inhibitors:
Slovenian: skupni aktivni zaviralci HMG Co-Areduktaze:
English: Since efavirenz is highly protein-bound, dialysis is unlikely to remove significant quantities of it from blood.
Slovenian: Ker se efavirenz močno veže na proteine, je malo verjetno, da bi z dializo iz krvi lahko odstranili znatnejšo količino efavirenza.
English: AUC: ↓ 25% (↓ 16 to ↓32)
Slovenian: AUC: ↓ 25 % (↓ 16 do ↓ 32)
English: Efavirenz has not been adequately studied in patients with advanced HIV disease, namely in patients with CD4 counts < 50 cells/mm3, or after failure of protease inhibitor (PI)-containing regimens.
Slovenian: Uporabe zdravila Efavirenz Teva še niso dovolj preučili pri bolnikih z napredovano boleznijo HIV, to je pri bolnikih z vrednostjo CD4 < 50 celic/mm3, ali po neuspelem zdravljenju z režimom, ki je vključeval zaviralce proteaze (ZP).
English: In HIV infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Sindrom imunske reaktivacije Pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART) lahko nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične okužbe.
English: < 400 copies/ml (95% C.I.b)
Slovenian: < 400 kopij/ml (95-odstotni IZb)
English: If you notice any of these symptoms please inform your doctor.
Slovenian: Če opazite katerega od teh simptomov, prosimo,
English: - nervousness, forgetfulness, confusion, fitting (seizures), abnormal thoughts - blurred vision - a feeling of spinning or tilting (vertigo) - pain in the abdomen (stomach) caused by inflammation of the pancreas - allergic reaction (hypersensitivity) that may cause severe skin reactions (erythema multiforme,
Slovenian: - občutek vrtenja (vrtoglavica) - bolečine v trebuhu (želodcu) zaradi vnetja trebušne slinavke - alergijska reakcija (preobčutljivost), ki lahko povzroči hude kožne reakcije (multiformni eritem,
English: - Medicines used to treat convulsions/seizures (anticonvulsants): carbamazepine, phenytoin,
Slovenian: - Zdravila za zdravljenje konvulzij/napadov krčev (antikonvulzivi): karbamazepin, fenitoin, fenobarbital.
English: Multipack: 90 (3 packs of 30 x 1) film-coated tablets
Slovenian: Škatla: 90 (3 zloženke po 30 x 1) filmsko obloženih tablet
English: ‡These adverse reactions were identified through post-marketing surveillance but not reported as drug-related events for efavirenz-treated patients in 16 clinical trials.
Slovenian: ‡Te neželene učinke so odkrili med spremljanjem zdravila na trgu, vendar o njih v 16 kliničnih preizkušanjih pri bolnikih, zdravljenjih z efavirenzem, niso poročali kot o z zdravilom povezanih neželenih učinkih.
English: Telaprevir (relative to 750 mg q8h):
Slovenian: telaprevir (glede na 750 mg na 8 ur):
English: When using efavirenz with low-dose ritonavir, the possibility of an increase in the incidence of
Slovenian: Pri uporabi efavirenza z majhnim odmerkom ritonavirja, je treba upoštevati možnost povečanja pogostnosti neželenih učinkov,
English: Pregnancy, breast-feeding and fertility Women should not get pregnant during treatment with Efavirenz Teva and for 12 weeks thereafter.
Slovenian: Nosečnost, dojenje, plodnost Ženske med jemanjem in 12 tednov po prenehanju jemanja zdravila Efavirenz Teva ne smejo zanositi.
English: Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Slovenian: Znaki osteonekroze so togost sklepa, bolečnost, bolečine (zlasti v kolku,
English: There have also been post-marketing reports of severe depression, death by suicide, delusions, psychosis-like behaviour and catatonia.
Slovenian: Tudi v obdobju trženja zdravila so poročali o hudi obliki depresije, smrti zaradi samomora, prividih, vedenju,
English: Hypromellose 6cP (HPMC 2910) Lactose monohydrate Titanium dioxide Macrogol/PEG 3350
Slovenian: Filmska obloga hipromeloza 6cP (HPMC 2910) laktoza monohidrat titanov dioksid makrogol/PEG 3350 triacetin 3 rumeni železov oksid
English: Common (affects 1 to 10 users in 100)
Slovenian: Pogosti (pojavijo se pri 1 do 10 od 100 bolnikov)
English: No effect (↔) equals a decrease in mean ratio estimate of ≤20% or increase in mean ratio estimate of administered with efavirenz.
Slovenian: Brez vpliva (↔) ustreza zmanjšanju povprečnega odstotka za ≤ 20 % ali zvečanju povprečnega odstotka za
English: Prophylaxis with appropriate antihistamines prior to initiating therapy with efavirenz in children may be considered.
Slovenian: Pri otrocih lahko pred uvedbo efavirenza razmislimo o profilaksi z ustreznimi antihistaminiki.
English: There have been seven retrospective reports of findings consistent with neural tube defects, including meningomyelocele, all in mothers exposed to efavirenz-containing regimens (excluding any efavirenzcontaining fixed-dose combination tablets) in the first trimester.
Slovenian: Na voljo je sedem retrospektivnih poročil o izsledkih, ki kažejo na okvare nevralne cevi, vključno z meningomielokelo, vsa pa pri materah, ki so bile izpostavljene režimu zdravljenja z efavirenzem
English: (400/100 mg twice daily/ 600 mg once daily)
Slovenian: (400/100 mg dvakrat na dan/600 mg enkrat na dan)
English: Forty-three patients 3 months to 21 years of age (median 9.6 years) were dosed with efavirenz.
Slovenian: Z efavirenzem se je zdravilo triinštirideset bolnikov, starih od 3 mesecev do 21 let (mediana 9,6 leta).
English: Cmin: ↓ 12% (↓ 24% to ↑ 1%)
Slovenian: Cmin: ↓ 12 % (↓ 24 do ↑ 1)
English: AUC: ↓ 7% (↓ 23 to ↑ 13) * Cmax: ↑ 23% (↓ 1 to ↑ 53) *
Slovenian: AUC: ↓ 7 % (↓ 23 do ↑ 13)* Cmax: ↑ 23 % (↓ 1 do ↑ 53)*
English: If you are affected your doctor may suggest that you take Efavirenz Teva at bedtime and on an empty stomach.
Slovenian: Če se pojavijo pri vas, vam bo zdravnik morda svetoval, da zdravilo Efavirenz Teva jemljete pred spanjem in na tešče.
English: outweighs the risk.
Slovenian: razen če korist za bolnika pretehta tveganje.
English: protease inhibitors: darunavir, indinavir, lopinavir/ritonavir, ritonavir, ritonavir-boosted atazanavir, saquinavir or fosamprenavir/saquinavir.
Slovenian: zaviralce proteaze: darunavir, indinavir, lopinavir/ritonavir, ritonavir, z ritonavirom okrepljen atazanavir, sakvinavir ali fosamprenavir/sakvinavir.
English: AUC: ↔ Cmax: ↑ 50% (↑ 20 to ↑ 80)
Slovenian: AUC: ↔ Cmax: ↑ 50 % (↑ 20 do ↑ 80)
English: The frequency category of "rare" was defined per A Guideline on Summary of Product Characteristics (SmPC) (rev. 2, Sept. 2009) on the basis of an estimated upper bound of the 95% confidence interval for 0 events given the number of patients treated with efavirenz in these clinical trials (n=3,969).
Slovenian: Povzetek glavnih značilnosti zdravila (SmPC) (A Guideline on Summary of Product Characteristics, rev. 2., sep. 2009) na podlagi ocenjene zgornje meje 95-odstotnega intervala zaupanja za 0 dogodkov,
English: Efavirenz has not been studied in controlled studies in patients with advanced HIV disease, namely with CD4 counts < 50 cells/mm3, or in PI or NNRTI experienced patients.
Slovenian: Klinična učinkovitost Efavirenza niso preučevali v nadzorovanih študijah pri bolnikih z napredovalo boleznijo HIV, to je pri bolnikih s CD4 < 50 celic/mm3, ali bolnikih, ki so se že zdravili z zaviralcem proteaze ali NNRTI.
English: EFV, efavirenz; ZDV, zidovudine; 3TC, lamivudine; IDV, indinavir; NRTI, nucleoside reverse transcriptase inhibitor; NFV, nelfinavir.
Slovenian: EFV + IDV + NRTI-ji IDV + NRTI-ji a NK = NA, ni končal = napaka analize b EFV, efavirenz; ZDV, zidovudin; 3TC, lamivudin; IDV, indinavir; NRTI, zaviralec nukleozidne reverzne transkriptaze; NFV, nelfinavir.
English: Efavirenz Teva may make hormonal contraceptives less likely to work.
Slovenian: Efavirenz Teva lahko zmanjša delovanje hormonskih kontraceptivov.
English: AUC: ↔*/** (↓ 10 to ↑ 26) Cmax: ↔*/** (↓ 5 to ↑ 26) Cmin: ↑ 12%*/** (↓ 16 to ↑ 49)
Slovenian: AUC: ↔*/** (↓ 10 do ↑ 26) Cmax: ↔*/** (↓ 5 do ↑ 26) Cmin : ↑ 12 %*/** (↓ 16 do ↑ 49)
English: It is an antiretroviral medicine that fights human immunodeficiency virus (HIV-1) infection by reducing the amount of the virus in blood.
Slovenian: ki zmanjšuje količino virusa v krvi in se tako bori proti okužbi z virusom humane imunske pomanjkljivosti (HIV-1).
English: Delusion ‡, neurosis ‡, completed suicide‡,* Nervous system disorders Common Cerebellar co-ordination and balance disturbances†, disturbance in attention (3.6%), dizziness (8.5%), headache (5.7%), somnolence (2.0%)* Uncommon Agitation, amnesia, ataxia, co-ordination abnormal, convulsions, thinking abnormal*, tremor†
Slovenian: Bolezni živčevja pogosti motnje cerebelarne koordinacije in ravnotežja†, motnje koncentracije (3,6 %), omotica (8,5 %), glavobol (5,7 %), zaspanost (2,0 %)*
English: Efavirenz Teva may interact with other medicines, including herbal preparations such as Ginkgo biloba extracts.
Slovenian: Med zdravilom Efavirenz Teva in drugimi zdravili, vključno s pripravki rastlinskega izvora, kot so izvlečki ginka (Ginkgo biloba), lahko pride do medsebojnega vpliva.
English: Amylase: In the clinical trial subset of 1,008 patients, asymptomatic increases in serum amylase levels greater than 1.5 times the upper limit of normal were seen in 10% of patients treated with efavirenz and 6% of patients treated with control regimens.
Slovenian: Amilaze: v kliničnem preizkušanju so v podskupini 1.008 bolnikov asimptomatska zvišanja vrednosti serumskih amilaz, večja kot 1,5-kratna zgornja meja normalne vrednosti, opazili pri 10 % bolnikov,
English: (CYP3A4 and CYP2B6 induction)
Slovenian: (indukcija CYP3A4 in CYP2B6)
English: <50 copies/ml (95% C.I.b)
Slovenian: < 50 kopij/ml (95-odstotni IZb)
English: Your doctor may require you to take a pregnancy test to ensure you are not pregnant before starting treatment with Efavirenz Teva.
Slovenian: Zdravnik vam bo morda naročil, da pred začetkom zdravljenja z zdravilom Efavirenz Teva, opravite test nosečnosti, da se prepriča, da niste noseči.
English: No clinically significant pharmacokinetic interaction The geometric mean Cmin for indinavir (0.33 mg/l) when given with ritonavir and efavirenz was higher than the mean historical Cmin (0.15 mg/l) when indinavir was given alone at 800 mg q8h.
Slovenian: Geometrična srednja vrednost Cmin za indinavir (0,33 mg/l) pri dajanju z ritonavirjem in efavirenzem je bila večja kot srednja vrednost Cmin v preteklosti (0,15 mg/l) za indinavir samo v odmerku 800 mg na vsakih 8 ur.
English: The increased efavirenz concentrations observed following administration of efavirenz with food may lead to an increase in frequency of adverse reactions (see sections 4.4 and 5.2).
Slovenian: Povišana koncentracija efavirenza, ki so jo opazili po zaužitju efavirenza s hrano, lahko vodi do povečane pogostosti neželenih učinkov (glejte poglavji 4.4 in 5.2).
English: Peak efavirenz plasma concentrations of 1.6-9.1 microM were attained by 5 hours following single oral doses of 100 mg to 1,600 mg administered to uninfected volunteers.
Slovenian: Maksimalne plazemske koncentracije efavirenza, 1,6 - 9,1 µM, so bile pri neokuženih prostovoljcih dosežene 5 ur po dajanju enkratnih peroralnih odmerkov 100 mg do 1.600 mg. Od odmerka odvisna zvišanja Cmax in AUC so opazili pri odmerkih do 1.600 mg.
English: Other medicines and Efavirenz Teva You must not take Efavirenz Teva with certain medicines.
Slovenian: Zdravila Efavirenz Teva ne smete jemati skupaj z določenimi zdravili.
English: Liver enzymes in hepatitis B or C co-infected patients In the long-term data set from study 006, 137 patients treated with efavirenz-containing regimens (median duration of therapy, 68 weeks) and 84 treated with a control regimen (median duration, 56 weeks) were seropositive at screening for hepatitis B (surface antigen positive) and/or C (hepatitis C antibody positive).
Slovenian: Po dolgoročnih podatkih iz študije 006 je bilo ob presejanju seropozitivnih na hepatitis B (pozitivnih na površinski antigen) in/ali C (pozitivnih na protitelo proti hepatitisu C) 137 bolnikov na režimu, ki je vseboval efavirenz (mediana vrednost časa trajanja zdravljenja 68 tednov), in 84 bolnikov na kontrolnem režimu (mediana vrednost časa trajanja 56 tednov).
English: (PLIVA Croatia Ltd.), Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia
Slovenian: (PLIVA Croatia Ltd.), Prilaz baruna Filipovića 25, 10000 Zagreb, Hrvaška Za vse morebitne nadaljnje informacije o tem zdravilu se lahko obrnete na predstavništvo imetnika dovoljenja za promet z zdravilom:
English: - Keep this leaflet.
Slovenian: (glejte spodaj).
English: Efavirenz Teva may reduce the amount of voriconazole in your blood and voriconazole may increase the amount of efavirenz in your blood.
Slovenian: Zdravilo Efavirenz Teva lahko zmanjša količino vorikonazola v krvi, vorikonazol pa lahko poveča količino efavirenza v krvi.
English: Lumefantrine:
Slovenian: lumefantrin:
English: Tests may show: - increased liver enzymes in the blood - increased triglycerides (fatty acids) in the blood
Slovenian: Testi lahko pokažejo: - povišane vrednosti jetrnih encimov v krvi
English: In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Slovenian: pojavijo tudi avtoimunske bolezni (stanja, do katerih pride, ko imunski sistem napade zdravo telesno tkivo).
English: Study 020 enrolled 327 patients who had been treated with NRTIs but not with PIs or NNRTIs.
Slovenian: 327 bolnikov, zdravljenih z NRTI, ne pa z ZP ali NNRTI.
English: Despite the decrease in buprenorphine exposure, no patients exhibited withdrawal symptoms.
Slovenian: buprenorfinu se pri bolnikih niso pokazali odtegnitveni simptomi.
English: In a study of HIV infected intravenous drug users, co-administration of efavirenz with methadone resulted in decreased plasma levels of methadone and signs of opiate withdrawal.
Slovenian: (indukcija CYP3A4) V študiji pri uživalcih intravenskih drog, okuženih z virusom HIV, je sočasna uporaba efavirenza in metadona povzročila zmanjšanje ravni metadona v plazmi in znake odtegnitve od opiatov.
English: Approximately 14-34% of a radiolabelled dose of efavirenz was recovered in the urine and less than 1% of the dose was excreted in urine as unchanged efavirenz.
Slovenian: Približno 14 - 34 % radiooznačenega odmerka efavirenza se je izločilo z urinom.
English: AUC: ↔* (↓ 9 to ↑ 10) Cmax: ↑ 17%* (↑ 8 to ↑ 27) Cmin: ↓ 42%* (↓ 31 to ↓ 51)
Slovenian: AUC: ↔* (↓ 9 do ↑ 10) Cmax: ↑ 17 %* (↑ 8 do ↑ 27) Cmin : ↓ 42 %* (↓ 31 do ↓ 51)
English: AUC: ↔ Cmax: ↑ 11% (↑ 3 to ↑19)
Slovenian: AUC: ↔ Cmax: ↑ 11 % (↑ 3 do ↑ 19)
English: - Methadone (a medicine used to treat opiate addiction): your doctor may recommend an alternative treatment.
Slovenian: - Metadon (zdravilo za zdravljenje odvisnosti od opiatov): zdravnik vam bo morda svetoval drugo zdravljenje.
English: Breast-feeding should be discontinued during treatment with efavirenz.
Slovenian: Med zdravljenjem z efavirenzem je treba dojenje prekiniti.
English: concentrations for at least 2 weeks (until stable concentrations are reached) is recommended when starting or stopping treatment with efavirenz.
Slovenian: Na začetku ali ob prenehanju zdravljenja z efavirenzem priporočamo skrbno spremljanje koncentracij imunosupresiva vsaj 2 tedna (dokler niso dosežene stabilne koncentracije).
English: Time to peak plasma concentrations (3-5 hours) did not change following multiple dosing and steady-state plasma concentrations were reached in 67 days.
Slovenian: Čas za doseganje maksimalne plazemske koncentracije (3-5 ur) se pri večkratnem odmerjanju ni spremenil.
English: How to take Efavirenz Teva
Slovenian: Kako jemati zdravilo Efavirenz Teva
English: Efavirenz Teva 600 mg film-coated tablets
Slovenian: Efavirenz Teva 600 mg filmsko obložene tablete
English: Efavirenz is contraindicated with concomitant use of drugs (they may cause prolonged QTc interval and Torsade de Pointes) such as: antiarrhythmics of classes IA and III, neuroleptics and antidepressant agents, certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones, imidazole, and triazole antifungal agents, certain non-sedating antihistaminics (terfenadine, astemizole), cisapride, flecainide, certain antimalarials and methadone (see section 4.3).
Slovenian: Efavirenz je kontraindiciran pri sočasni uporabi zdravil (povzročijo lahko podaljšanje intervala QTc in torsade de pointes) kot so: antiaritmiki razreda IA in III, nevroleptiki in antidepresivi, določeni antibiotiki, vključno z nekaterimi učinkovinami iz naslednjih razredov: makrolidi, fluorokinoloni,
English: General disorders and administration site conditions Common Fatigue *,†, ‡ See section c. Description of selected adverse reactions for more details.
Slovenian: *, †, ‡ Za več podrobnosti glejte poglavje c. Opis izbranih neželenih učinkov.
English: AUC: ↓ 31% (↓ 8 to ↓47) Cmin: ↓ 40%
Slovenian: AUC: ↓ 31 % (↓ 8 do ↓ 47) Cmin: ↓ 40 %
English: - Ginkgo biloba extracts (a herbal preparation)
Slovenian: - Izvlečke ginka (pripravek rastlinskega izvora).