FrancophonIA/ELRC3.0 huggingface dataset:
English: Tell your doctor immediately, before or after taking this medicine, if you notice any of the following symptoms, which could be a sign of another, more serious, disease: - an unintentional loss of weight (not related to a diet or an exercise programme) - vomiting, particularly if repeated - vomiting blood; this may appear as dark coffee grounds in your vomit - you notice blood in your stools; which may be black or tarry in appearance - difficulty in swallowing or pain when swallowing - you look pale and feel weak (anaemia) - chest pain - stomach pain - severe and/or persistent diarrhoea, because this medicine has been associated with a small increase in infectious diarrhoea.
Croatian: Odmah obavijestite svog liječnika, prije ili nakon uzimanja ovog lijeka, ako primijetite neki od sljedećih simptoma koji može biti znak druge, ozbiljnije bolesti: - nenamjeran gubitak težine (koji nije vezan uz dijetu ili program tjelovježbe) - povraćanje, osobito ako se ponavlja - povraćanje krvi, što možete primijetiti u obliku tamnih zrnaca veličine zrna kave - krv u stolici, koja može biti crna ili poput katrana - teškoće pri gutanju ili bol pri gutanju - bljedoća ili osjećaj slabosti (anemija) - bol u prsnom košu - bol u trbuhu - težak i/ili stalan proljev, jer je ovaj lijek povezan sa malim porastom zaraznog proljeva - ako dobijete osip na koži, posebice na područjima izloženima suncu obavijestite svojeg liječnika što je prije moguće, jer ćete možda morati prekinuti liječenje lijekom CONTROLOC Control.
English: - methotrexate (used to treat rheumatoid arthritis, psoriasis, and cancer) - if you are taking methotrexate your doctor may temporarily stop your CONTROLOC Control treatment because pantoprazole can increase levels of methotrexate in the blood.
Croatian: - metotreksat (koristi se za liječenje reumatoidnog artritisa, psorijaze ili raka) - ako uzimate metotreksat liječnik će možda preporučiti da privremeno prekinete uzimati CONTROLOC
English: How to take CONTROLOC Control
Croatian: Kako uzimati CONTROLOC Control
English: - Printing ink: shellac, red, black and yellow iron oxide (E172) and ammonia solution, concentrated.
Croatian: - Tinta za označavanje: šelak, crveni, crni i žuti željezov oksid, (E172) i koncentrirana otopina amonijaka.
English: Decreased gastric acidity, due to any means - including proton pump inhibitors - increases gastric counts of bacteria normally present in the gastrointestinal tract.
Croatian: Gastrointestinalne infekcije izazvane bakterijama Smanjena kiselost u želucu koja nastaje iz bilo kojeg razloga-uključujući uzimanje inhibitora protonske pumpe-povećava brojnost bakterija koje su inače prisutne u gastrointestinalnom traktu.
English: Abdominal distension and bloating; Constipation ; Dry mouth; Abdominal pain and discomfort
Croatian: proljev; mučnina / povraćanje; distenzija abdomena i nadutost; konstipacija; suha usta; bol i nelagoda u abdomenu
English: Stop taking CONTROLOC Control when you are completely symptom-free.
Croatian: Control kada nastupi potpuno povlačenje simptoma.
English: Do not take CONTROLOC Control tablets for more than 4 weeks without consulting your doctor.
Croatian: Control tablete dulje od 4 tjedna bez savjetovanja s liječnikom.
English: - fracture of your hip, wrist or spine, especially if you already suffer from osteoporosis or if you are taking corticosteroids (which can increase the risk of osteoporosis).
Croatian: - smanjenje apsorpcije vitamina B12 i pomanjkanje vitamina B12 ako su vam tjelesne zalihe vitamina B12 već smanjene. - prijelom kuka, zapešća ili kralježnice, posebno ako već bolujete od osteoporoze ili ako uzimate kortikosteroide (koji mogu povećati rizik od osteoporoze).
English: CONTROLOC Control 20 mg gastro-resistant tablets Pantoprazole
Croatian: CONTROLOC Control 20 mg želučanootporne tablete pantoprazol
English: - Frequency not known: hallucination, confusion (especially in patients with a history of these symptoms); decreased level of sodium in blood; decreased level of magnesium in blood, rash, possibly with pain in the joints; feeling of tingling, prickling, pins and needles, burning sensation or numbness, inflammation in the large bowel, that causes persistent watery diarrhoea.
Croatian: Nepoznata učestalost: halucinacije, smetenost (pogotovo kod bolesnika koji su već imali te simptome), smanjenje razine natrija u krvi; smanjenje razine magnezija u krvi; osip, moguće praćen boli u zglobovima; osjećaj bockanja, peckanja, trnaca i mravinjanja, žarenja ili utrnulosti, upala debelog crijeva koja uzrokuje ustrajan vodenasti proljev.
English: Hepatocellular injury; Jaundice; Hepatocellular failure
Croatian: povišenje bilirubina oštećenje jetre; žutica; hepatocelular no zatajenje
English: CONTROLOC Control is indicated for short-term treatment of reflux symptoms (e.g. heartburn, acid regurgitation) in adults.
Croatian: Control je indiciran za kratkotrajno liječenje simptoma refluksa (npr. žgaravica, regurgitacija kiseline) u odraslih.
English: Agranulocytosis Thrombocytopenia ; Leukopenia,
Croatian: Poremećaji krvi i limfnog sustava agranulocitoza trombocitopenija; leukopenija, pancitopenija
English: - if you have been treated for heartburn or indigestion continuously for 4 or more weeks - if you are over 55 years old and taking non-prescription indigestion treatment on a daily basis - if you are over 55 years old with any new or recently changed reflux symptoms - if you have previously had a gastric ulcer or stomach surgery - if you have liver problems or jaundice (yellowing of skin or eyes) - if you regularly see your doctor for serious complaints or conditions - if you are due to have an endoscopy or a breath test called a C-urea test. - if you have ever had a skin reaction after treatment with a medicine similar to CONTROLOC
Croatian: - ako ste imali čir na želucu ili operaciju želuca - ako imate probleme s jetrom ili žuticu (žutilo kože ili očiju) - ako redovno posjećujete liječnika zbog neke ozbiljne bolesti ili stanja - ako ste naručeni na endoskopiju ili C-urea izdisajni test - ako ste ikad imali kožnu reakciju nakon terapije s lijekom sličnim lijeku CONTROLOC
English: How to store CONTROLOC Control
Croatian: Kako čuvati CONTROLOC Control
English: CONTROLOC Control is used for the short-term treatment of reflux symptoms (for example heartburn, acid regurgitation) in adults.
Croatian: Control se koristi za kratkotrajno liječenje simptoma refluksa (npr. žgaravica, vraćanje kiseline iz želuca u usta) u odraslih.
English: Pregnancy and, breast-feeding
Croatian: Trudnoća i dojenje
English: CONTROLOC Control 20 mg gastro-resistant tablets
Croatian: CONTROLOC Control 20 mg želučanootporne tablete
English: - Serious skin reactions (frequency not known: frequency cannot be estimated from the available data): rash with swelling, blistering or peeling of the skin, losing skin and bleeding around eyes, nose, mouth or genitals and rapid deterioration of your general health, or rash when exposed to the sun. - Other serious reactions (frequency not known): yellowing of the skin and eyes (due to severe liver damage), or kidney problems such as painful urination and lower back pain with fever.
Croatian: Tipični simptomi su: oticanje lica, usana, usta, jezika i/ili grla, što može uzrokovati teškoće pri gutanju ili disanju, koprivnjača (urtikarija), jaka omaglica s vrlo brzim otkucajima srca i izrazitim znojenjem. - ozbiljne kožne reakcije (nepoznata učestalost: učestalost se ne može procijeniti iz dostupnih podataka): osip sa oticanjem, stvaranje mjehurića na koži ili ljuštenje kože, gubljenje kože i krvarenje oko očiju, nosa, usta ili genitalija, brzo pogoršanje općeg zdravstvenog stanja, ili osip nastao kod izlaganja suncu. - ostale ozbiljne reakcije (nepoznata učestalost): žutilo kože i očiju (zbog teškog oštećenja jetre) ili problemi s bubrezima kao što je bolno mokrenje i bol u donjem dijelu leđa s vrućicom.
English: - warfarin and phenprocoumon (used to thin blood and prevent clots).
Croatian: Pogledajte 'Ne uzimajte CONTROLOC Control'. - ketokonazol (koristi se za gljivične infekcije) - varfarin i fenprokumon (koristi se za razrjeđivanje krvi i sprječavanje ugrušaka).
English: - if you are due to have a specific blood test (Chromogranin A) - if you are taking HIV protease inhibitors such as atazanavir; nelfinavir (for the treatment of
Croatian: Control koji smanjuje želučanu kiselinu - ako morate napraviti određenu krvnu pretragu (kromogranin A). - ako istodobno s pantoprazolom uzimate inhibitore HIV proteaze kao što su atazanavir i nelfinavir (za liječenje infekcije HIV-om), posavjetujte se s liječnikom.
English: Tabulated list of adverse reactions The following adverse reactions have been reported with pantoprazole.
Croatian: Prijavljene su sljedeće nuspojave pantoprazola.
English: If you forget to take CONTROLOC Control
Croatian: Prestanite uzimati CONTROLOC
English: Subacute cutaneous lupus erythematosus (see section
Croatian: Lyellov sindrom; erythema multiforme; fotoosjetljivo st; subakutni kožni lupus eritematodes (pogledajte dio 4.4.).
English: Hyperlipidaemias and lipid increases (triglycerides, cholesterol);
Croatian: Poremećaji metabolizma i prehrane hiperlipidemije i povišenja lipida (triglicerida, kolesterola); promjene u tjelesnoj težini hiponatrijemi ja; hipomagnezij emija; hipokalcijemi ja
English: EU (MA) number
Croatian: EU (MA) broj
English: 1 After reconstitution, each dose (2 ml) contains 1.4-2.5 x 106 chondrogenic induced equine allogeneic peripheral blood-derived mesenchymal stem cells .
Croatian: 1 Nakon miješanja, svaka doza (2 ml) sadrži hondrogeno inducirane, alogenične mezenhimske matične stanice izvedene iz periferne krvi konja (1,42,5 x 106).
English: 1 vial of stem cell suspension + 1 vial of plasma suspension
Croatian: 1 bočica sa suspenzijo m matičnih stanica + 1 bočica sa suspenzijo m plazme
English: Suspension (plasma): 1 ml
Croatian: Suspenzija (plazma): 1 ml
English: Suspension (plasma): vial (plastic).
Croatian: Suspenzija (plazma): bočica (plastična).
English: Horses Intraarticular use Suspension (stem cells): vial (plastic).
Croatian: Suspenzija (matične stanice): bočica (plastična).
English: No formal statistical comparisons were planned.
Croatian: Nisu planirane formalne statističke usporedbe.
English: Follow all the doctor's instructions carefully.
Croatian: Pažljivo slijedite sve liječničke upute.
English: Includes different bleeding events from different sites not listed individually c
Croatian: Uključuje različite događaje krvarenja iz različitih mjesta koji nisu pojedinačno navedeni c
English: Afinitor may also: weaken your immune system.
Croatian: Afinitor također može: oslabiti Vaš imunološki sustav.
English: What Afinitor is and what it is used for
Croatian: Što je Afinitor i za što se koristi
English: Open the blister just before taking the tablets.
Croatian: Blister otvorite neposredno prije uzimanja tableta.
English: Plus exemestane b
Croatian: Plus eksemestan b
English: Population n
Croatian: Populacija n
English: Intermediate risk
Croatian: Srednji rizik
English: NSE: Neuron specific enolase
Croatian: NSE: Neuron specifična enolaza
English: Your doctor will tell you how many tablets of Afinitor to take.
Croatian: Liječnik će Vam reći koliko tableta Afinitora ćete uzimati.
English: CgA: Chromogranin A
Croatian: CgA: Kromogranin A
English: If you take more Afinitor than you should
Croatian: Ako uzmete više Afinitora nego što ste trebali
English: Discontinue treatment if failure to recover within 4 weeks.
Croatian: Prekinuti liječenje ako nema oporavka unutar 4 tjedna.
English: They may differ from the general information contained in this leaflet.
Croatian: One se mogu razlikovati od općih informacija koje sadrži ova uputa.
English: Frequency based upon number of women from 10 to 55 years of age in the pooled data
Croatian: Učestalost temeljena na broju žena od 10 do 55 godina u objedinjenim podacima
English: Probability (%)
Croatian: Vjerojatnost (%)
English: Afinitor could harm your unborn baby and is not recommended during pregnancy.
Croatian: Afinitor može naštetiti Vašem nerođenom djetetu te se ne preporučuje tijekom trudnoće.
English: Your doctor will discuss with you whether you should take this medicine during your pregnancy.
Croatian: Vaš će liječnik s Vama raspraviti hoćete li uzimati ovaj lijek tijekom trudnoće.
English: Children and adolescents Afinitor is not to be used in children or adolescents (age below 18 years).
Croatian: Djeca i adolescenti Afinitor nije namijenjen za primjenu u djece ili adolescenata (mlađi od 18 godina).
English: STOP taking Afinitor and seek medical help immediately if you experience any of the following signs of an allergic reaction:
Croatian: PRESTANITE uzimati Afinitor i odmah potražite liječničku pomoć ako osjetite bilo koji od sljedećih znakova alergijske rekacije:
English: Other medicines and Afinitor
Croatian: Drugi lijekovi i Afinitor
English: The increase in exemestane levels is unlikely to have an impact on efficacy or safety.
Croatian: Nije vjerojatno da bi porast razina eksemestana imao učinka na djelotvornost ili sigurnost primjene.
English: Reactivation of infection is an expected event during periods of immunosuppression.
Croatian: Reaktivacija infekcije je očekivani događaj tijekom razdoblja imunosupresije.
English: The safety and efficacy of Afinitor in children aged 0 to 18 years have not been established.
Croatian: Sigurnost i djelotvornost Afinitora u djece u dobi od 0 do 18 godina nisu još ustanovljene.
English: Some mouthwashes and gels can make ulcers worse, so do not try anything without checking with your doctor first.
Croatian: Neke otopine za ispiranje usta i gelovi mogu pogoršati ranice, stoga ne pokušavajte ništa bez prethodne provjere s Vašim liječnikom.
English: Stratified log-rank test
Croatian: Stratificirano log-rank testom
English: What you need to know before you take Afinitor
Croatian: Što morate znati prije nego počnete uzimati Afinitor
English: Re-initiate treatment at same dose.
Croatian: Ponovno započeti liječenje u istoj dozi.
English: Independent radiological review
Croatian: Neovisna radiološka procjena
English: Talk to your doctor before taking Afinitor: if you have any problems with your liver or if you have ever had any disease which may have affected your liver.
Croatian: Obratite se svom liječniku prije nego uzmete Afinitor: ako imate bilo kakvih problema s jetrom ili ako ste ikada imali neku bolest kojom je mogla biti zahvaćena jetra.
English: Supportive/sensitivity analyses All (local review by investigator)
Croatian: Suportivna analiza/analiza osjetljivosti Svi (lokalna procjena od strane ispitivača)
English: • Passing urine more often during daytime
Croatian: • Češće mokrenje tijekom dana
English: Aluminium/polyamide/aluminium/PVC blister containing 10 tablets.
Croatian: Aluminij/poliamid/aluminij/PVC blister sadrži 10 tableta.
English: Probability (%) of event
Croatian: Vjerojatnost (%) događaja
English: The Independent Data Monitoring Committee recommended termination of this trial at the time of the second interim analysis as the primary endpoint had been met.
Croatian: Nezavisno povjerenstvo koje prikuplja podatke je preporučilo prekid ovog ispitivanja u vrijeme kada je napravljena druga interim analiza, jer je primarni ishod bio postignut.
English: Date of first authorisation: 03 August 2009 Date of latest renewal: 16 May 2014
Croatian: Datum posljednje obnove odobrenja: 16. svibnja 2014.
English: Kaplan-Meier medians
Croatian: Kaplan-Meierovi medijani
English: Afinitor tablets should be swallowed whole with a glass of water.
Croatian: Afinitor tablete moraju se progutati cijele sa čašom vode.
English: Table 4 BOLERO-2 efficacy results
Croatian: Tablica 4 BOLERO-2 rezultati djelotvornosti
English: If you feel unusually tired (fatigue is a very common side effect), take special care when driving or using machines.
Croatian: Ako se osjećate neuobičajeno umorno (umor je vrlo česta nuspojava), budite oprezni dok upravljate vozilima ili strojevima.
English: leukopenia, lymphopenia and/or neutropenia)
Croatian: leukopenija, limfopenija i/ili neutropenija)
English: If you think you may be allergic, ask your doctor for advice.
Croatian: Ako mislite da biste mogli biti alergični, potražite savjet od svog liječnika.
English: Treatment should continue as long as clinical benefit is observed or until unacceptable toxicity occurs.
Croatian: Liječenje treba nastaviti sve dok postoji klinička dobit ili do pojave neprihvatljive toksičnosti.
English: You might need treatment with a mouthwash, gel or other products.
Croatian: Možda ćete trebati primjenu otopine za ispiranje usta, gela ili drugih proizvoda.
English: Table 5 RADIANT-3 - efficacy results
Croatian: Tablica 5 RADIANT-3 - rezultati djelotvornosti
English: Best overall response (%) (95% CI) Objective response rate b
Croatian: Najbolji ukupan odgovor (%) (95% CI) Stopa objektivnog odgovora b
English: • Mild loss of hair
Croatian: • Blagi gubitak kose
English: Other possible side effects of Afinitor include:
Croatian: Druge moguće nuspojave Afinitora uključuju:
English: Your doctor might restart treatment with Afinitor at the same dose or at a lower dose.
Croatian: Vaš liječnik bi mogao ponovno započeti liječenje Afinitorom u istoj dozi ili u nižoj dozi.
English: Efavirenz, nevirapine Not studied.
Croatian: Efavirenz, nevirapin Nije ispitivano.
English: Afinitor contains lactose (milk sugar).
Croatian: Afinitor sadrži laktozu (mliječni šećer).
English: Not applicable e p value is obtained from the exact Cochran-Mantel-Haenszel test using a stratified version of the Cochran-Armitage permutation test.
Croatian: Nije primjenjivo e p vrijednost preuzeta je iz egzaktnoga Cochran-Mantel-Haenszelovog testa primjenom stratificirane verzije Cochran-Armitageovog permutacijskog testa.
English: The grades follow CTCAE Version 3.0 and 4.03.
Croatian: Stupnjevi nuspojava određeni su prema CTCAE Verziji 3.0 i 4.03.
English: Talk to your doctor if you wish to have children.
Croatian: Popričajte sa svojim liječnikom ako želite imati djecu.
English: Table 3 Adverse reactions reported in clinical studies
Croatian: Tablica 3 Nuspojave prijavljene u kliničkim ispitivanjima
English: In the safety pooling, 37% of the Afinitor-treated patients were ≥65 years of age.
Croatian: U objedinjenim sigurnosnim podacima, 37% bolesnika liječenih Afinitorom imalo je ≥65 godina.
English: If you have taken too much Afinitor, or if someone else accidentally takes your tablets, see a doctor or go to a hospital immediately.
Croatian: Ako ste uzeli previše Afinitora, ili je netko drugi zabunom popio Vaše tablete, odmah se javite liječniku ili otiđite u bolnicu.
English: Rare (may affect up to 1 in 1,000 people) • Shortness of breath or rapid breath (signs of acute respiratory distress syndrome)
Croatian: Rijetke (mogu se javiti kod do 1 na 1000 osoba) • Nedostatak zraka ili ubrzano disanje (znakovi sindroma akutnog respiratornog distresa)
English: Primary analysis All (blinded independent central review)
Croatian: Primarna analiza Svi (slijepa neovisna centralna procjena)
English: Afinitor will only be prescribed for you by a doctor with experience in cancer treatment.
Croatian: Afinitor će Vam propisati liječnik s iskustvom u liječenju raka.
English: MSKCC prognostic score (blinded independent central review) Favourable risk
Croatian: MSKCC prognostička ljestvica (slijepa neovisna centralna procjena) Povoljan rizik
English: Confirmed objective tumour responses were observed in 5 patients (2%) receiving Afinitor, while none were observed in patients receiving placebo.
Croatian: Potvrđeni objektivni tumorski odgovori zabilježeni su u 5 bolesnika (2%) koji su primili Afinitor, dok u bolesnika koji su primili placebo nije zabilježen niti jedan.
English: Frequency categories are defined using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000).
Croatian: Kategorije učestalosti definirane su na sljedeći način: vrlo često (≥1/10); često (≥1/100 i <1/10); manje često (≥1/1000 i <1/100); rijetko (≥1/10 000 i <1/1000); vrlo rijetko (<1/10 000).
English: Infections and infestations Very common Infections a, *
Croatian: Infekcije i infestacije Vrlo često Infekcije a,
English: Women who could potentially become pregnant should use highly effective contraception during treatment.
Croatian: Tijekom liječenja, žene koje bi mogle zatrudnjeti moraju provoditi visoko učinkovitu kontracepciju.
English: If you experience any of these side effects, tell your doctor immediately as this might have life-threatening consequences.
Croatian: Ako osjetite bilo koju od nuspojava, odmah obavijestite svog liječnika, jer posljedice mogu biti opasne po život.
English: Afinitor should be administered orally once daily at the same time every day, consistently either with or without food (see section 5.2).
Croatian: Afinitor je potrebno uzimati peroralno, jednom dnevno, svaki dan u isto vrijeme, dosljedno ili uz obrok ili bez obroka (vidjeti dio 5.2).
English: Fifty-eight percent of the patients in both arms received prior systemic therapy.
Croatian: Pedesetosam posto bolesnika u obje skupine prethodno je primalo sistemsko liječenje.
English: If you have liver problems, your doctor may start you on a lower dose of Afinitor (2.5, 5 or 7.5 mg per day).
Croatian: Ako imate probleme s jetrom, liječnik će možda započeti liječenje nižom dozom Afinitora (2,5, 5 ili 7,5 mg na dan).
English: If a dose is missed, the patient should not take an additional dose, but take the next prescribed dose as usual.
Croatian: U slučaju propuštene doze, bolesnik ne smije uzeti dodatnu dozu, već uzeti uobičajeno propisanu sljedeću dozu.
English: Investigator radiological review a
Croatian: Radiološka procjena od strane ispitivača a
English: Afinitor may affect the way some other medicines work.
Croatian: Afinitor može utjecati na mehanizam djelovanja nekih drugih lijekova.
English: Management of severe and/or intolerable suspected adverse reactions may require dose reduction and/or temporary interruption of Afinitor therapy.
Croatian: Zbrinjavanje suspektnih teških i/ili nepodnošljivih nuspojava moglo bi zahtijevati smanjenje doze i/ili privremeni prekid liječenja Afinitorom.
English: Serious side effects of Afinitor include:
Croatian: Ozbiljne nuspojave Afinitora uključuju:
English: Swallow the tablet(s) whole with a glass of water.
Croatian: Tabletu(e) progutajte cijele s čašom vode.
English: Very common Weight decreased * See also subsection “Description of selected adverse reactions”
Croatian: Vrlo često Gubitak tjelesne težine * Vidjeti i pododjeljak „Opis odabranih nuspojava“
English: Afinitor may elevate cholesterol and/or other blood fats.
Croatian: Afinitor može povisiti razine kolesterola i/ili drugih masnoća u krvi.
English: The tablets should not be chewed or crushed.
Croatian: Tablete se ne smiju žvakati niti drobiti.
English: • Trouble sleeping (insomnia)
Croatian: • Otežano spavanje (nesanica)
English: If symptoms are moderate (Grade 2) or severe (Grade 3) the use of corticosteroids may be indicated until clinical symptoms resolve.
Croatian: Ako su simptomi umjereni (stupanj 2) ili teški (stupanj 3) možda će biti indicirana primjena kortikosteroida dok se klinički simptomi ne povuku.
English: Randomisation was stratified by documented sensitivity to prior hormonal therapy and by the presence of visceral metastasis.
Croatian: Dodatna randomizacija provedena je s obzirom na dokumentiranu osjetljivost na prethodno hormonsko liječenje i prisutnosti visceralnih metastaza.
English: • Pink eye or red eye (conjunctivitis)
Croatian: • Ljubičasto ili crveno oko (konjuktivitis)
English: Grade 4 Discontinue treatment.
Croatian: Stupanj 4 Prekinuti liječenje.
English: Afinitor may have a minor or moderate influence on the ability to drive and use machines.
Croatian: Afinitor može malo ili umjereno utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Objective response rate = proportion of patients with complete or partial response c
Croatian: Stopa objektivnog odgovora = udio bolesnica s potpunim ili djelomičnim odgovorom c
English: Grade 2 If toxicity is tolerable, no dose adjustment required.
Croatian: Stupanj 2 Ako je toksičnost podnošljiva, nije potrebno prilagođavanje doze.