FrancophonIA/ELRC3.0 huggingface dataset:
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with alfuzosin is contraindicated.
Slovenian: Sočasna uporaba zdravila Aptivus ob hkratnih majhnih odmerkih ritonavirja in alfuzosina je kontraindicirana.
English: In in vitro experiments, tipranavir was observed to inhibit human platelet aggregation at levels consistent with exposures observed in patients receiving Aptivus with ritonavir.
Slovenian: Pri poskusih in vitro je bil zaviralni učinek tipranavirja na agregacijo humanih trombocitov v skladu z izpostavljenostjo pri bolnikih, ki so prejemali zdravilo Aptivus ob ritonavirju.
English: 150 mg/m 2 ritonavir, twice daily.
Slovenian: 150 mg/m 2 ritonavirja.
English: Switching from Aptivus oral solution to the capsules Aptivus oral solution is not interchangeable with the capsules.
Slovenian: Prehod z zdravila Aptivus peroralna raztopina na kapsule Zdravilo Aptivus peroralna raztopina ni zamenljivo s kapsulami.
English: Omeprazole and other proton pump inhibitors
Slovenian: Omeprazol in drugi zaviralci protonske črpalke
English: 500 mg Tipranavir co-administered with low dose ritonavir (200 mg; twice daily) was associated with a 29-fold increase in the geometric mean morning steady-state trough plasma concentrations compared to tipranavir 500 mg twice daily without ritonavir.
Slovenian: Tipranavir 500 mg je ob hkratnih majhnih odmerkih ritonavirja (200 mg; dvakrat na dan) povzročil 29-kratno povečanje vrednosti geometrične sredine jutranjih ravnovesnih plazemskih koncentracij v primerjavi s tipranavirjem brez ritonavirja, po 500 mg dvakrat na dan.
English: PARTICULARS TO APPEAR ON THE OUTER FOLDING BOX/OUTER PACKAGING
Slovenian: PODATKI NA ZUNANJI OVOJNINI ŠKATLA/ZUNANJA OVOJNINA
English: Each capsule contains 250 mg tipranavir.
Slovenian: Ena kapsula vsebuje 250 mg tipranavirja.
English: No dosage adjustments are recommended.
Slovenian: Ni priporočil o prilagajanju odmerkov.
English: Saquinavir/ritonavir 600/100 mg QD
Slovenian: Sakinavir/ritonavir 600/100 mg 1-krat na dan
English: NAME OF THE MEDICINAL PRODUCT Aptivus 250 mg soft capsules tipranavir
Slovenian: IME ZDRAVILA Aptivus 250 mg mehke kapsule tipranavir
English: Due to the marked hepatotoxicity of bosentan and the potential for increasing the liver toxicity associated with Aptivus,co-administered with low dose ritonavir, this combination is not recommended.
Slovenian: Zaradi znatne hepatotoksičnosti bosentana in možnega povečanja toksičnega delovanja zdravila Aptivus ob hkratnih majhnih odmerkih ritonavirja te kombinacije ne priporočajo.
English: Open the bottle by pressing down on the cap and turning it in an anti-clockwise direction.
Slovenian: Steklenico odprite s pritiskom na zaporko, ki jo nato zavrtite v obratni smeri urinega kazalca.
English: Pharmacokinetic enhancer Cobicistat and cobicistatcontaining products
Slovenian: Farmakokinetični stopnjevalec Kobicistat in zdravila, ki ga vsebujejo
English: Abacavir Cmax ↓ 46% Abacavir AUC ↓ 36%
Slovenian: Cmax abakavirja ↓ 46% AUC abakavirja ↓ 36%
English: - If you have any further questions, please ask your child's doctor or pharmacist.
Slovenian: Če imate dodatna vprašanja, se prosim posvetujte z otrokovim zdravnikom ali farmacevtom.
English: Ask your child's pharmacist how to throw away medicines you no longer use.
Slovenian: O načinu odstranjevanja zdravila, ki ga ne uporabljateveč, se posvetujte z otrokovim farmacevtom.
English: low dose ritonavir (this helps Aptivus to reach a high enough level in your child's blood) other HIV medicines.
Slovenian: - majhnimi odmerki ritonavirja (da bi zdravilo Aptivus v krvi otroka lahko dosegel dovolj veliko raven), - drugimi zdravili proti virusu HIV.
English: Tipranavir Cmax  8% Tipranavir AUC  20% Tipranavir Cmin  75%
Slovenian: Cmax tipranavirja  8% AUC tipranavirja  20% Cmin tipranavirja  75%
English: The mechanisms and potential mechanisms contributing to the interaction profile of tipranavir are described (see section 4.5).
Slovenian: Opisani so mehanizmi in možni mehanizmi medsebojnega delovanja s tipranavirjem (glejte poglavje
English: Through a series of multiple stepwise regression analyses of baseline and on-treatment genotypes from all clinical studies, 16 amino acids have been associated with reduced tipranavir susceptibility and/or reduced 48-week viral load response: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D and 84V.
Slovenian: Z nizom stopenjskih regresijskih analiz izhodiščnih genotipov in genotipov med zdravljenjem v vseh kliničnih študijah so z zmanjšano občutljivostjo za tipranavir ali zmanjšanim 48-tedenskim odzivom virusnega bremena povezali 16 aminokislin: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D in 84V.
English: Narcotic analgesics Methadone 5 mg QD Methadone Cmax ↓ 55% Methadone AUC ↓ 53% Methadone Cmin ↓ 50%
Slovenian: Cmax metadona ↓ 55% AUC metadona ↓ 53% Cmin metadona ↓ 50%
English: Therefore patients should not be switched from Aptivus capsules to Aptivus oral solution (see sections 5.1 and 5.2).
Slovenian: Zato bolnikom zdravila Aptivus kapsule ne smemo zamenjati za zdravilo Aptivus peroralna raztopina (glejte poglavji 5.1 in 5.2).
English: You should continue to take Aptivus for as long as your doctor tells you.
Slovenian: Zdravilo Aptivus morate jemati tako dolgo, kot vam je predpisal zdravnik.
English: Colchicine
Slovenian: Kolhicin
English: Loperamide 16 mg QD Loperamide Cmax ↓ 61% Loperamide AUC ↓ 51%
Slovenian: Cmax loperamida ↓ 61% AUC loperamida ↓ 51%
English: Didanosine 200 mg BID, ≥ 60 kg (TPV/r 250/200 mg BID) - 125 mg BID, < 60 kg (TPV/r 750/100 mg BID)
Slovenian: Didanozin, 200 mg 2-krat na dan, ≥ 60 kg (TPV/r 250/200 mg 2-krat na dan) - 125 mg 2-krat na dan, < 60 kg (TPV/r, 750/100 mg 2-krat na dan)
English: Therefore, tipranavir with ritonavir should not be used in treatment-naïve patients (see section 4.2).
Slovenian: Zato tipranavirja z ritonavirjem ne smemo dajati bolnikom, ki se prvič zdravijo (glejte poglavje 4.2).
English: Rare: may affect up to 1 in 1,000 people - Liver failure (including fatal outcome) - Hepatitis - Fatty liver - Increased blood levels of bilirubin (a breakdown product of haemoglobin) - Dehydration (when the body does not have enough water) - Thinning of the face - Bleeding in the brain* (see above) - Increased blood levels of the pancreas enzyme lipase
Slovenian: Redki: pojavijo se lahko pri največ 1 od 1.000 bolnikov jetrna odpoved (tudi s smrtnim izidom), hepatitis, zamaščena jetra, povečana raven bilirubina v krvi (razpadni produkt hemoglobina), dehidracija (premajhna količina vode v telesu), hujšanje v obraz, možganska krvavitev* (glejte zgoraj), povečana raven encima trebušne slinavke lipaze v krvi.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestitezdravnika ali farmacevta, če jemljete,ste pred kratkimjemali ali pa boste morda začeli jemati katero kolidrugozdravilo, tudi če ste ga dobili brez recepta.
English: You should inform your child's doctor as soon as possible if you notice your child has the signs or symptoms of hepatitis: - fever - malaise (feeling generally unwell) - nausea (upset stomach) - vomiting - abdominal pain
Slovenian: Čim prej obvestite otrokovega zdravinika, če opazite da ima vaš otrok znake ali simptome hepatitisa, kot so: - vročina, - splošno slabo počutje,
English: If your child takes more Aptivus than he/she should Inform your child's doctor as soon as possible if they take more than the prescribed dose of Aptivus.
Slovenian: Če je vaš otrok vzel večji odmerek zdravila Aptivus, kot bi smel Če je vaš otrok vzel večji odmerek zdravila Aptivus od predpisanega, čim prej obvestite njegovega zdravnika.
English: This score (counting the 16 amino acids that have been associated with reduced tipranavir susceptibility and/or reduced viral load response: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D and 84V) was applied to baseline viral protease sequences.
Slovenian: To oceno (štetje 16 aminokislin, ki jih povezujejo z zmanjšano občutljivostjo za tipranavir ali zmanjšanim odzivom virusnega bremena: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D in 84V) so povezali z izhodiščnimi sekvencami virusne proteaze.
English: In such cases no dosage adjustment of abacavir can be recommended (see section
Slovenian: Za takšne primere ni priporočil za prilagoditev odmerjanja abakavirja (glejte poglavje 4.4).
English: Monitoring of digoxin serum concentrations is recommended until steady state has been obtained.
Slovenian: Dokler se ne vzpostavi stanje dinamičnega ravnovesja, je priporočljivo spremljati koncentracijo digoksina v serumu..
English: Therefore, the concomitant use of zidovudine or abacavir with Aptivus, co-administered with low dose ritonavir, is not-recommended unless there are no other available NRTIs suitable for patient management (see section 4.5).
Slovenian: Zato sočasne uporabe zidovudina ali abakavirja z zdravilom Aptivus, ob hkratnih majhnih odmerkih ritonavirja, ne priporočamo, razen kadar ni na voljo drugih nukleozidnih zaviralcev reverzne transkriptaze, ki bi bili primerni za zdravljenje (glejte poglavje 4.5).
English: Herbal preparations containing St John's wort (Hypericum perforatum) due to the risk of decreased plasma concentrations and reduced clinical effects of tipranavir (see section 4.5).
Slovenian: Pripravki rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum), ker lahko zmanjšajo koncentracijo tipranavirja v plazmi in oslabijo njegove klinične učinke (glejte poglavje 4.5).
English: Intracranial haemorrhage (ICH) was only observed in post marketing experience (see section 4.4).
Slovenian: O intrakranialni krvavitvi so poročali le v obdobju po začetku trženja zdravila (glejte poglavje 4.4).
English: Response rates were higher in tipranavir with ritonavir patients than comparator PI boosted with ritonavir in new enfuvirtide patients, or patients without new enfuvirtide.
Slovenian: Stopnja odzivnosti je bila pri bolnikih, ki so jemali tipranavir ob ritonavirju, večja kot pri primerjanem zaviralcu proteaze (PI), okrepljenem z ritonavirjem, in sicer pri bolnikih, ki so prvič prejeli enfuvirtid ali pa le-tega niso prejeli.
English: Lopinavir/ritonavir 400/100 mg BID
Slovenian: Lopinavir/ritonavir 400/100 mg 2-krat na dan
English: Aptivus oral solution is available for children between 2 and 12 years of age (please refer to the respective SmPC for further details).
Slovenian: Za otroke, stare 2 do 12 let, je na voljo peroralna raztopina Aptivus (podrobnejše podatke najdete v ustreznem Povzetku glavnih značilnosti zdravila).
English: Rifabutin 150 mg QD Rifabutin Cmax ↑ 70% Rifabutin AUC ↑ 190%
Slovenian: Cmax rifabutina ↑ 70% AUC rifabutina ↑ 190% Cmin rifabutina ↑ 114%
English: Baseline characteristics for patients 2 - <12 years treated with Aptivus oral solution
Slovenian: Izhodiščne značilnosti bolnikov, starih 2 do < 12 let, zdravljenih s peroralno raztopino Aptivus
English: Of note, patients in the RESIST studies had a specific mutational pattern at baseline of at least one primary protease gene mutation among codons 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V or 90M, and no more than two mutations on codons 33, 82, 84 or 90.
Slovenian: Pomemben je podatek, da so imeli bolniki v raziskavi RESIST specifičen izhodiščni mutacijski vzorec, in sicer najmanj eno primarno mutacijo gena za proteazo med kodoni 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V ali 90 M in ne več kot dve mutaciji na kodonih 33, 82, 84 ali 90.
English: Genotypic or phenotypic testing (when available) and treatment history should guide the use of Aptivus.
Slovenian: Vodilo pri uporabi zdravila Aptivus morajo biti genotipsko in fenotipsko testiranje (kadar je možno) ter podatki o prejšnjem zdravljenju.
English: UNIQUE IDENTIFIER --- HUMAN READABLE DATA
Slovenian: EDINSTVENA OZNAKA - V BERLJIVI OBLIKI
English: could be expected.
Slovenian: Lahko je usodna.
English: Atazanavir/ritonavir 300/100 mg QD (TPV/r 500/100 mg BID)
Slovenian: Atazanavir/ritonavir 300/100 mg 1-krat na dan (TPV/r, 500/100 mg 2-krat na dan)
English: Tipranavir, co-administered with low dose ritonavir, exhibits linear pharmacokinetics at steady state.
Slovenian: Tipranavir ima ob hkratnih majhnih odmerkih ritonavirja v ravnovesnem stanju linearno farmakokinetiko.
English: Protease inhibitors other than those listed above
Slovenian: Zaviralci proteaze, razen že naštetih
English: The metabolism of tipranavir in the presence of low dose ritonavir is minimal.
Slovenian: Tipranavir se v prisotnosti majhnih odmerkov ritonavirja minimalno presnavlja.
English: If you use oral contraceptives or HRT you have an increased chance of developing a skin rash while taking Aptivus.
Slovenian: Če boste uporabljali peroralne kontraceptive ali zdravila za hormonsko nadomestno zdravljenje, se bo med jemanjem zdravila Aptivus povečala verjetnost razvoja kožnega izpuščaja.
English: 25-O-desacetylrifabutin Cmin ↑ 7.8 fold
Slovenian: Cmin 25-O-dezacetilrifabutina ↑ 7,8-krat
English: low dose ritonavir (this helps Aptivus to reach a high enough level in your blood) other HIV medicines.
Slovenian: - majhnimi odmerki ritonavirja (da bi zdravilo Aptivusv krvi lahko dosegel dovolj veliko raven), - drugimi zdravili proti virusu HIV.
English: The clinical relevance of this reduction in didanosine concentrations has not been established.
Slovenian: Klinični pomen zmanjšanja didanozinove koncentracije ni raziskan.
English: Reactivation of herpes simplex and herpes zoster virus infections were observed in the RESIST trials.
Slovenian: V raziskavah RESIST so zasledili reaktivacijo okužb z virusom herpes simpleks in herpes zoster.
English: Failure to correctly co-administer tipranavir with ritonavir will result in reduced plasma levels of tipranavir that may be insufficient to achieve the desired antiviral effect.
Slovenian: Če hkratnega dajanja tipranavirja in ritonavirja ne izvajamo pravilno, je koncentracija tipranavirja v plazmi manjša in včasih ne zadošča za želeni protivirusni učinek.
English: However, since the renal clearance of tipranavir is negligible, a decrease in total body clearance is not expected in patients with renal impairment.
Slovenian: Ker je njegov ledvični očistek neznaten, pri bolnikih z ledvično okvaro ne pričakujemo zmanjšanja skupnega očistka iz telesa.
English: This indication is based on the results of one phase II study investigating pharmacokinetics, safety and efficacy of Aptivus oral solution in mostly treatment-experienced children aged 2 to 12 years.
Slovenian: faze, v kateri so proučevali farmakokinetiko, varnost in učinkovitost peroralne raztopine Aptivus pri otrocih, starih 2 do 12 let, ki so se pred tem večinoma že zdravili.
English: Steady-state tipranavir/r: S-warfarin Cmax ↓ 17% S-warfarin AUC ↓ 12%
Slovenian: Tipranavir/r v ravnovesnem stanju: Cmax S-varfarina ↓ 17% AUC varfarina ↓ 12%
English: PP * Composite endpoint defined as patients with a confirmed 1 log RNA drop from baseline and without evidence of treatment failure ** Comparator PI/RTV: LPV/r 400 mg/100 mg twice daily (n=358), IDV/r 800 mg/100 mg twice daily (n=23), SQV/r 1000 mg/100 mg twice daily or 800 mg/200 mg twice daily (n=162), APV/r 600 mg/100 mg twice daily (n=194)
Slovenian: PP * Sestavljeni opazovani dogodek opredeljen kot bolniki s potrjenim zmanjšanjem 1 log RNA glede na izhodiščno vrednost in brez znakov neuspešnega zdravljenja ** PI/RTV primerjalnega zdravljenja: LPV/r 400 mg/100 mg dvakrat na dan (n = 358).
English: Lopinavir Cmax ↓ 47% Lopinavir AUC ↓ 55% Lopinavir Cmin ↓ 70%
Slovenian: Cmax lopinavirja ↓ 47% AUC lopinavirja ↓ 55% Cmin lopinavirja ↓ 70%
English: Tipranavir phenotypic resistance
Slovenian: Fenotipska odpornost proti tipranavirju
English: You must take Aptivus in combination with low dose ritonavir and other antiretroviral medicines.
Slovenian: Zdravilo Aptivus morate jemati v kombinaciji z majhnimi odmerki ritonavirja in drugimi protiretrovirusnimi zdravili.
English: Based on theoretical considerations, tipranavir or ritonavir concentrations might increase upon co-administration with itraconazole or ketoconazole.
Slovenian: Po presoji na teoretični podlagi se lahko poveča koncentracija tipranavirja ali ritonavirja pri sočasnem dajanju z itrakonazolom ali s ketonazolom.
English: Your child must take Aptivus in combination with low dose ritonavir and other antiretroviral medicines.
Slovenian: Zdravilo Aptivus mora vaš otrok jemati v kombinaciji z majhnimi odmerki ritonavirja in drugimi protiretrovirusnimi zdravili.
English: In case of concomitant administration of emtricitabine and Aptivus/ritonavir, renal function should be evaluated before initiating the co-administration.
Slovenian: Pred sočasno uporabo emtricitabina in zdravila Aptivusa/ritonavirja je treba oceniti ledvično delovanje.
English: Compared to the capsules, tipranavir exposure is higher when administering the same dose as oral solution.
Slovenian: V primerjavi s kapsulami je po dajanju enakega odmerka peroralne raztopine izpostavljenost tipranavirju večja.
English: You should therefore carefully read the Package Leaflets of ritonavir and your other antiretroviral medicines.
Slovenian: Natančno preberite navodila za uporabo ritonavirja in vaših drugih protiretrovirusnih zdravil.
English: Volume Aptivus (ml)
Slovenian: Volumen zdravila Aptivus(ml)
English: It is difficult to predict the net effect of Aptivus co-administered with low dose ritonavir on oral bioavailability and plasma concentrations of agents that are dual substrates of CYP3A and P-gp.
Slovenian: Neto učinek zdravila Aptivus, ob hkratnih majhnih odmerkih ritonavirja, na peroralno biološko uporabnost in koncentracije zdravil, ki so dvojni substrati CYP3A in P-gp, v plazmi je težko predvideti.
English: * AIDS defining illness
Slovenian: Srednje število prejšnjih PI *bolezen, ki opredeljuje AIDS
English: Didanosine Cmax ↓ 24% Didanosine AUC ↔
Slovenian: Cmax didanozina ↓ 24% AUC didanozina ↔
English: Muscle disorders
Slovenian: Mišične motnje
English: At least one primary protease gene mutation from among 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V or 90M had to be present at baseline, with not more than two mutations on codons 33, 82, 84 or 90.
Slovenian: Na začetku raziskave so morali bolniki imeti najmanj eno primarno gensko mutacijo proteaze od 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V ali 90M in ne več kot dve mutaciji na kodonih 33, 82, 84 ali 90.
English: No dosing adjustment is required in patients with mild hepatic impairment but patients should be closely monitored (see sections 4.2 and
Slovenian: Bolnikom z blago jetrno okvaro odmerka ni treba prilagajati, vendar jim morajo skrbno spremljati (glejte poglavji 4.2 in 4.4).
English: Some of the side effects of Aptivus may affect your ability to drive or operate machinery (e.g. dizziness and sleepiness).
Slovenian: Vpliv na sposobnost upravljanjavozil in strojev Nekateri neželeni učinki zdravila Aptivus lahko zmanjšajo sposobnost za vožnjo avtomobila ali upravljanje strojev(npr. omotica in zaspanost).
English: First-dose tipranavir/r Digoxin Cmax ↔ Digoxin AUC ↔
Slovenian: Prvi odmerek tipranavirja/r Cmax digoksina ↔ AUC digoksina ↔
English: Fluticasone
Slovenian: Flutikazon
English: No dosage adjustment necessary.
Slovenian: Odmerjanja ni treba prilagoditi.
English: Co-administration of colchicine with Aptivus/ritonavir in patients with renal or hepatic impairment (see section 4.5).
Slovenian: Sočasna uporaba kolhicina in zdravila Aptivus/ritonavirja pri bolnikih z ledvično ali jetrno okvaro (glejte poglavje 4.5).
English: Based on theoretical considerations tipranavir, co-administered with low dose ritonavir, is expected to increase itraconazole or ketoconazole concentrations.
Slovenian: Po presoji na teoretični podlagi tipranavir ob hkratnih majhnih odmerkih ritonavirja poveča koncentracijo itrakonazola ali ketokonazola.
English: Concentrations of cyclosporin, tacrolimus, or sirolimus cannot be predicted when co-administered with tipranavir co-administered with low dose ritonavir, due to conflicting effect of tipranavir, coadministered with low dose ritonavir, on CYP 3A and P-gp.
Slovenian: Pri hkratnem dajanju s tipranavirjem ob majhnih odmerkih ritonavirja koncentracij ciklosporina, takrolimusa ali sirolimusa ne moremo napovedati zaradi zapletenega učinka tipranavirja ob hkratnih majhnih odmerkih ritonavirja na CYP 3A in P-gp.
English: First-dose tipranavir/r Midazolam Cmax ↑ 5.0 fold Midazolam AUC ↑ 27 fold
Slovenian: Prvi odmerek tipranavirja/r Cmax midazolama ↑ 5,0-krat AUC midazolama ↑ 27-krat
English: Co-administration of Aptivus/ritonavir with sildenafil, when used to treat pulmonary arterial hypertension, is contraindicated.
Slovenian: Sočasna uporaba zdravila Aptivus/ritonavirja s sildenafilom je pri zdravljenju pljučne arterijske hipertenzije kontraindicirana.
English: 600/100 mg BID
Slovenian: 600/100 mg 2-krat na dan
English: emtricitabine: If you are taking emtricitabine your kidney function should be checked before initiation of Aptivus.
Slovenian: Če jemljete emtricitabin, je treba opraviti preiskavo delovanja ledvic, preden boste začeli jemati zdravilo Aptivus.
English: In such cases no dosage adjustment of zidovudine can be recommended (see section
Slovenian: Za takšen primer ni priporočil o prilagajanju odmerkov zidovudina (glejte poglavje 4.4).
English: Open the bottle by pressing down on the cap and turning in an anti-clockwise direction.
Slovenian: Odprite steklenico s pritiskom na zaporko, katero nato zavrtite v obratni smeri urinega kazalca.
English: The combined use of Aptivus with ritonavir with either omeprazole, esomeprazole or with other proton pump inhibitors is not recommended (see section 4.5).
Slovenian: Kombinirane uporabe zdravila Aptivus ob ritonavirju z omeprazolom, esomeprazolom ali drugimi zaviralci protonske črpalke ne priporočamo (glejte poglavje 4.5).
English: You should therefore carefully read the Package Leaflets of ritonavir and your child's other antiretroviral medicines.
Slovenian: Natančno preberete navodila za uporabo ritonavirja in otrokovih drugih protiretrovirusnih zdravil.
English: CYP 3A4 inhibition by tipranavir/r and P-gp (an intestinal efflux transporter) inhibition by clarithromycin.
Slovenian: Tipranavir/r zavira CYP 3A4, klaritromicin pa P-gp (efluksni prenašalec v črevesu).
English: 40 mg BID > 60 kg 30 mg BID < 60 kg (TPV/r 750/100 mg BID)
Slovenian: 40 mg 2-krat na dan > 60 kg 30 mg 2-krat na dan < 60 kg (TPV/r, 750/100 mg 2-krat na dan)
English: Adults and adolescents (from 12 - 18 years of age) The recommended dose of Aptivus is 500 mg, co-administered with 200 mg ritonavir (low dose ritonavir), twice daily (see section 4.4 for precautionary measures in adolescents).
Slovenian: Priporočeni odmerek zdravila Aptivus je 500 mg, hkrati z 200 mg ritonavirja (ritonavir v majhnih odmerkih), dvakrat na dan (za previdnostne ukrepe pri mladostnikih glejte poglavje 4.4).
English: How to store Aptivus
Slovenian: Shranjevanje zdravila Aptivus
English: Common: may affect up to 1 in 10 people - Vomiting - Abdominal pain (tummy pain) - Flatulence (breaking wind more often) - Tiredness - Headache - Mild rashes e.g. with hives or with flat or raised small red spots - Increases in blood lipid (fat) levels - Dyspepsia
Slovenian: Pogosti: pojavijo se lahko pri največ 1 od 10 bolnikov bruhanje, abdominalna bolečina (trebušna bolečina), napenjanje(pogosti vetrovi), utrujenost, glavobol, blag izpuščaj, npr. s koprivnico ali ploskimi ali privzdignjenimi rdečimi lisami, povečanja lipidov (maščob) v krvi, dispepsija.
English: Tipranavir is metabolised by the hepatic system.
Slovenian: Tipranavir se presnavlja v jetrih.
English: Clarithromycin 500 mg BID
Slovenian: Antibiotiki Klaritromicin 500 mg 2-krat na dan
English: If you take more Aptivus than you should Inform your doctor as soon as possible if you take more than the prescribed dose of Aptivus.
Slovenian: Če ste vzeli večji odmerek zdravila Aptivus, kot bi smeli Če ste vzeli večji odmerek zdravila Aptivus od predpisanega, čim prej obvestite zdravnika.