FrancophonIA/ELRC3.0 huggingface dataset:
English: Therefore care should be taken if ospemifene is administered with a BCRP inhibitor.
Danish: Der skal derfor udvises forsigtighed, hvis ospemifen administreres sammen med en BCRP-hæmmer.
English: The risk of cerebrovascular events associated with ospemifene cannot be excluded.
Danish: Risikoen for cerebrovaskulære hændelser i forbindelse med ospemifen kan ikke udelukkes.
English: Systemic exposure (AUC) at the administered doses was 0.3-, 1.0- and 1.2-times the AUC in postmenopausal woman administered 60 mg/day.
Danish: Den systemiske eksponering (AUC) ved de administrerede doser var 0,3, 1,0 og 1,2 gange AUC'en hos postmenopausale kvinder, som fik administreret 60 mg/dag.
English: In healthy subjects, the absorption of ospemifene is not affected by co-administration of oral omeprazole, a medicinal product that increases gastric pH.
Danish: Hos raske forsøgspersoner blev absorptionen af ospemifen ikke påvirket af den samtidige administration af peroral omeprazol, et lægemiddel, som øger gastrisk pH.
English: Oestrogens.
Danish: • Østrogener.
English: Carbamazepine and phenytoin used to treat convulsions/seizures (anticonvulsants).
Danish: o Carbamazepin og phenytoin, som bruges til behandling af kramper/krampetrækninger (antiepileptika).
English: The clinical efficacy and safety of ospemifene was determined primarily from two multi-centre, placebo-controlled trials of 12 weeks duration (trials 1 and 2) and a third long-term safety trial of 52 weeks duration (trial 3) in post-menopausal patients with VVA.
Danish: Ospemifens kliniske virkning og sikkerhed blev påvist hovedsageligt ved to multicenter-, placebokontrollerede studier af 12 ugers varighed (studie 1 og 2) og et tredje, længerevarende sikkerhedsstudie af 52 ugers varighed (studie 3) hos postmenopausale patienter med VVA.
English: If you stop using Senshio
Danish: Hvis du holder op med at bruge Senshio
English: These changes in pharmacokinetics of ospemifene by moderate hepatic impairment are not considered to be clinically significant in consideration of inherent pharmacokinetic variability of ospemifene.
Danish: Disse ændringer i ospemifens farmakokinetik ved moderat leverinsufficiens betragtes ikke som klinisk signifikante i betragtning af ospemifens iboende farmakokinetiske variabilitet.
English: Systemic exposure (AUC) at these doses was 2.1-, 4.0- and 4.7-times the AUC in postmenopausal woman administered 60 mg/day.
Danish: Den systemiske eksponering (AUC) ved disse doser var 2,1, 4,0 og 4,7 gange AUC'en hos postmenopausale kvinder, som fik administreret 60 mg/dag.
English: Ospemifene has not been formally studied in women with a prior history of breast cancer.
Danish: Ospemifen er ikke undersøgt formelt hos kvinder, hvis anamnese inkluderer brystcancer.
English: In patients with severe renal impairment the ospemifene exposure was increased by approximately 20%, when compared to healthy matched subjects.
Danish: Hos patienter med svær nyreinsufficiens var eksponeringen af ospemifen ca. 20% højere end hos raske, matchede forsøgspersoner.
English: Senshio has no or negligible influence on the ability to drive and use machines.
Danish: Senshio påvirker ikke eller kun i ubetydelig grad evnen til at føre motorkøretøj og betjene maskiner.
English: Decreases in oestrogen levels that occur after the menopause lead to VVA, characterised by decreased maturation of vaginal epithelial cells, a progressive decrease in the vascularity of the vaginal tissues, and decreased lubrication.
Danish: Reduktioner i østrogenniveauet, der forekommer efter menopause, fører til VVA, der karakteriseres ved nedsat modning af vaginale epitelceller, en progressiv reduktion i vaskulariteten af vaginalt væv og tørhed i skeden.
English: While taking Senshio:
Danish: Mens du tager Senshio:
English: Any other medicine belonging to the group called SERMs, such as tamoxifen, toremifene, bazedoxifene and raloxifene.
Danish: • Alle andre lægemidler, som tilhører gruppen SERM'er (selektive østrogen-receptor modulatorer), som f.eks. tamoxifen, toremifen, bazedoxifen og raloxifen.
English: Across all placebo controlled clinical trials, there was no significant difference in breast related adverse events between ospemifene and placebo.
Danish: Der var ikke nogen signifikant forskel på tværs af alle placebokontrollerede kliniske studier i brystrelaterede utilsigtede hændelser ospemifen og placebo imellem.
English: Senshio tablets are oval biconvex, white to off-white, film-coated tablets (approximately 12 mm long by 6.45 mm wide) debossed with “60” on one side.
Danish: Senshio tabletter er ovale, bikonvekse, mathvide, filmovertrukne tabletter (ca. 12 mm lang gange 6,45 mm bred), der er præget med "60" på den ene side.
English: No dose adjustment is necessary for patients with mild, moderate or severe renal impairment (see section 5.2).
Danish: Dosisjustering er ikke nødvendig for patienter med mild, moderat eller svær nyreinsufficiens (se pkt.
English: For subjects completing the trial 1 extension study (ospemifene, n=41; placebo, n= 18) and for subjects in the long-term 52-week safety study (trial 3: ospemifene, n=276; placebo, n=46), endometrial safety was assessed by endometrial biopsy at baseline and at 12 months.
Danish: For de forsøgspersoner, som gennemførte studie 1-forlængelsesstudiet (ospemifen, n=41; placebo, n= 18), og de forsøgspersoner, som deltog i det langvarige sikkerhedsstudie af 52 ugers varighed (studie 3: ospemifen, n=276; placebo, n=46), blev endometriel sikkerhed vurderet med endometriebiopsi ved baseline og efter12 måneder.
English: The risk of VTE associated with ospemifene cannot be excluded.
Danish: Risikoen for VTE i forbindelse med ospemifen kan ikke udelukkes.
English: There were four co-primary endpoints for which change from baseline was assessed: percentage parabasal cells and superficial cells in the vaginal smear, vaginal pH, and MBS of VVA (dryness or dyspareunia).
Danish: studiet inkluderede fire indbyrdes relaterede primære endepunkter, hvor ændringen i forhold til baseline blev vurderet: procentdel parabasale celler og overfladiske celler i vaginal celleprøve, vaginalt pH og mest generende symptom (MBS) ved VVA (tørhed eller dyspareuni).
English: What you need to know before you take Senshio Do not take Senshio
Danish: Det skal du vide, før du begynder at tage Senshio Tag ikke Senshio
English: Rifampicin, a strong CYP3A / CYP2C9 enzyme inducer, decreased the AUC of ospemifene by 58%.
Danish: Rifampicin, en stærk CYP3A/CYP2C9-enzyminduktor, reducerede AUC for ospemifen med 58 %.
English: Nonclinical findings show that ospemifene and its major metabolite have an oestrogen like effect in the vagina increasing the cellular maturation and mucification of the vaginal epithelium.
Danish: Ikke-kliniske resultater viser, at ospemifen og dets hovedmetabolit har en østrogenlignende virkning i skeden, idet de øger cellemodningen og fugtigheden af det vaginale epitel.
English: In in vitro studies, ospemifene and 4-hydroxyospemifene did not inhibit P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), organic anion transporter polypeptide (OATP)1B1, OATP1B3, OCT2, organic anion transporter (OAT)1, OAT3, or bile salt export pump (BSEP) transporters at clinically relevant concentrations.
Danish: I in vitro undersøgelser hæmmede ospemifen og 4-hydroxyospemifen ikke P-glycoprotein (P-gp), brystcancerresistent protein (BCRP), organisk aniontransportørpolypeptid (OATP)1B1, OATP1B3, OCT2, organisk aniontransportør (OAT)1, OAT3 eller galde-salt-eksportpumpe (BSEP) transportører ved klinisk relevante koncentrationer.
English: This medicine is only intended for use in postmenopausal women.
Danish: Dette lægemiddel er kun beregnet til kvinder efter overgangsalderen.
English: Trial 1 Trial 2
Danish: Studie 1 Studie 2
English: Other medicines and Senshio
Danish: Brug af anden medicin sammen med Senshio
English: The recommended dose is one tablet taken orally at the same time each day.
Danish: Den anbefalede dosis er én tablet, som tages gennem munden på samme tidspunkt hver dag.
English: Obligation to conduct post-authorisation measures
Danish: Forpligtelse til at gennemføre foranstaltninger efter udstedelse af markedsføringstilladelse
English: This increase is not considered to be clinically significant given the inherent pharmacokinetic variability of ospemifene.
Danish: Denne stigning betragtes ikke som værende klinisk signifikant i lyset af ospemifens iboende farmakokinetik.
English: No clinically important pharmacokinetic differences between subjects with severe renal impairment and healthy subjects were observed.
Danish: Der blev ikke observeret nogen klinisk vigtige, farmakokinetiske forskelle mellem forsøgspersoner med svær nyreinsufficiens og raske forsøgspersoner.
English: In the adrenal gland, there was an increased incidence of adrenal subcapsular cell and adrenal cortical tumours in animals dosed at high dose.
Danish: Der var i binyrerne øget incidens af adrenale subkapsulær celle- og adrenale kortikale tumorer hos dyr doseret ved høj dosis.
English: If you forget to take Senshio
Danish: Hvis du har glemt at tage Senshio
English: Hypromellose (E 464) Lactose monohydrate Titanium dioxide (E 171) Triacetin (E 1518) Macrogols (E 1521)
Danish: Hypromellose (E 464) Laktosemonohydrat Titandioxid (E 171) Triacetin (E 1518) Macrogoler (E 1521)
English: If pregnancy occurs during treatment with ospemifene, ospemifene should be withdrawn immediately.
Danish: Hvis patienten bliver gravid under anvendelse af ospemifen, skal lægemidlet straks seponeres.
English: If a dose is missed it should be taken with food as soon as the patient remembers.
Danish: Hvis en dosis glemmes, skal den tages i forbindelse med et måltid, så snart patienten husker det. Der må ikke tages en dobbeltdosis på samme dag.
English: In the liver, an increase in hepatocellular tumours were recorded at all ospemifene dose levels.
Danish: Der blev i leveren registreret en øgning i hepatocellulære tumorer ved alle dosisniveauer af ospemifen.
English: No dose adjustment is necessary in patients above the age of 65 years (see section 5.2).
Danish: Ældre (> 65 år) Dosisjustering er ikke nødvendig for patienter på 65 år og derover (se pkt.
English: Trial 2 Dyspareunia
Danish: Studie 2 Dyspareuni
English: Uncommon side effects (may affect up to 1 in 100 people): - Thickening of the womb lining (endometrium) as seen on ultrasound scan (endometrial hypertrophy).
Danish: Ikke almindelige bivirkninger (kan forekomme hos op til 1 ud af 100 patienter): - Fortykket livmoderslimhinde (endometrium) konstateret ved ultralydsscanning (hypertrofisk endometrium).
English: In vitro, ospemifene and 4-hydroxyospemifene did not inhibit or induce the activity of CYP450 enzymes at clinically relevant concentrations.
Danish: Ospemifen og 4-hydroxyospemifen hverken hæmmede eller inducerede aktiviteten af CYP450enzymer in vitro ved klinisk relevante koncentrationer.
English: Active or past history of venous thromboembolic events (VTEs), including deep vein thrombosis, pulmonary embolism and retinal vein thrombosis.
Danish: Patientens anamnese inkluderer aktiv eller tidligere venøse tromboemboliske hændelser (VTE'er), herunder dyb venetrombose, lungeemboli og retinal venetrombose.
English: Trial 1 Dyspareunia
Danish: Studie 1 Dyspareuni
English: Oval biconvex, white to off-white, film-coated tablets of dimensions 12 mm x 6.45 mm, debossed with “60” on one side.
Danish: Ovale, bikonvekse, mathvide, filmovertrukne tabletter i størrelsen 12 mm x 6,45 mm, præget med "60" på den ene side.
English: Effects of other medicinal products on ospemifene
Danish: Andre præparaters indvirkning på ospemifen
English: In CYP2C9 poor metabolizers, co-administration of CYP3A4 inhibitors may increase systemic concentration of ospemifene to a larger extent.
Danish: Hos personer med dårlig CYP2C9-metabolisering kan samtidig administration af CYP3A4-hæmmere øge den systemiske koncentration af ospemifen til et højere niveau.
English: Fluconazole, a moderate CYP3A / moderate CYP2C9 / strong CYP2C19 inhibitor, increased the AUC of ospemifene by 2.7-fold.
Danish: Fluconazol, en moderat CYP3A/moderat CYP2C9/stærk CYP2C19-hæmmer, øgede AUC for ospemifen 2,7 gange.
English: Trial 2 Dryness
Danish: Studie 2 Tørhed
English: - If you have unexplained vaginal bleeding.
Danish: - Hvis du har uforklarlig blødning fra skeden.
English: Ospemifene and its major metabolite, 4-hydroxyospemifene, inhibited organic cation transporter (OCT)1 in vitro at clinically relevant concentrations.
Danish: Ospemifen og dets hovedmetabolit, 4-hydroxyospemifen, hæmmede organisk kationtransportør (OCT)1 in vitro ved klinisk relevante koncentrationer.
English: Trial 1 Dryness
Danish: Studie 1 Tørhed
English: In a 2-year carcinogenicity study in female mice, ospemifene caused treatment related increases in neoplastic findings in the adrenal gland and ovary.
Danish: I et 2 år langt carcinogenicitetsstudie med hunmus forårsagede ospemifen behandlingsrelaterede stigninger i neoplastiske fund i binyrerne og ovarie.
English: Therefore, co-administration of ospemifene with strong/moderate CYP3A4 inhibitors should be avoided in patients who are known, or suspected to be CYP2C9 poor metabolizers based on genotyping or previous history/experience with other CYP2C9 substrates.
Danish: Administration af ospemifen samtidig med stærke/moderate CYP3A4-hæmmere skal derfor undgås hos patienter med en kendt eller mistænkt dårlig CYP2C9-metabolisering baseret på genotypebestemmelse eller tidligere anamnese/erfaring med andre CYP2C9-substrater.
English: - If you have excessive thickening of the womb lining such as endometrial hyperplasia.
Danish: - Hvis din livmoderslimhinde er væsentligt fortykket, som f.eks. ved endometriehypertrofi.
English: Ospemifene and its major metabolite, 4-hydroxyospemifene, are metabolised by multiple metabolic pathways, the main enzymes involved are UGT1A3, UGT2B7, UGT1A1 and UGT1A8, and CYP2C9,
Danish: Ospemifen og dens hovedmetabolit, 4-hydroxyospemifen, metaboliseres via flere metabolske pathways, hvor de vigtigste involverede enzymer er UGT1A3, UGT2B7, UGT1A1 og UGT1A8 og CYP2C9, CYP3A4 og CYP2C19.
English: Senshio is only for use in postmenopausal women and should not be used in women of child-bearing potential.
Danish: Senshio anvendes kun til postmenopausale kvinder og bør ikke anvendes til kvinder i den fertile alder.
English: If necessary, because of impaired tolerance, ospemifene should be stopped as long as treatment with fluconazole lasts.
Danish: Hvis det pga. nedsat tolerance skulle blive nødvendigt, skal ospemifen seponeres under hele behandlingsforløbet med fluconazol.
English: These changes result in clinical signs which include vaginal dryness, redness, petechiae, pallor, and friability in the mucosa.
Danish: Disse ændringer resulterer i kliniske tegn, som inkluderer tørhed i skeden, rødme, petekkier, bleghed og tynd/sart/tør slimhinde.
English: Caution is recommended when co-administering ospemifene with fluconazole (see section 4.5).
Danish: Der tilrådes forsigtighed ved samtidig administration af ospemifen og fluconazol (se pkt.
English: One tablet should be swallowed whole once daily with food and should be taken at the same time each day.
Danish: Patienten skal synke én tablet én gang dagligt i forbindelse med et måltid, og tabletten skal tages på samme tidspunkt hver dag.
English: Tell your doctor immediately if you become pregnant while taking Senshio; treatment should be stopped immediately.
Danish: Fortæl det straks til lægen, hvis du bliver gravid, mens du tager Senshio.
English: In case of impaired tolerance of ospemifene, the latter should be stopped as long as treatment with fluconazole lasts.
Danish: Ved nedsat tolerance over for ospemifen skal sidstnævnte seponeres under hele behandlingsforløbet med fluconazol.
English: Oxaliplatin, an anti-cancer medicine for advanced (metastatic) cancer of the large bowel (colon) or back passage (rectum).
Danish: o Oxaliplatin, som bruges til behandling af fremskreden (metastaserende) tyktarmskræft (kolon) eller endetarmskræft (rektum).
English: Overall, tumour development in these studies is believed to be the result of rodent specific hormonal mechanisms when treated during their reproductive lives; these findings are unlikely to have any clinical relevance in postmenopausal women.
Danish: Alt i alt menes tumorudvikling i disse studier at skyldes hormonelle mekanismer, som er specifikke for gnavere, når de behandles i deres formeringsdygtige liv.
English: Ketoconazole, a strong CYP3A4 inhibitor and moderate P-glycoprotein inhibitor, increased the AUC of ospemifene by 1.4-fold.
Danish: Ketoconazol, en stærk CYP3A4-hæmmer og moderat P-glycoproteinhæmmer, øgede AUC for ospemifen 1,4 gang.
English: The major metabolite, 4-hydroxyospemifene, was seen to undergo formation rate-limited elimination (with t1/2 similar to the parent compound) in a human mass balance study.
Danish: Det blev i et humant massebalancestudie observeret, at hovedmetabolitten, 4-hydroxyospemifen, undergik dannelseshastighedsbegrænset eliminering (med en t1/2, der svarer til stamstoffets).
English: Senshio contains lactose
Danish: Senshio indeholder lactose
English: Pharmacokinetics in subpopulations
Danish: Farmakokinetik hos specielle grupper
English: Ospemifene should be discontinued at least 4 to 6 weeks prior to and during prolonged immobilisation (e.g., post-surgical recovery, prolonged bed rest).
Danish: Ospemifen skal seponeres mindst 4 til 6 uger timer forud for og under længerevarende immobilisering
English: Co-administration of ketoconazole, a strong CYP3A4 inhibitor, increased the AUC of ospemifene by 1.4-fold.
Danish: Samtidig administration af ketoconazol, som er en stærk CYP3A4-hæmmer, bevirkede en 1,4 gange forøgelse af AUC for ospemifen.
English: - The other ingredients are: Tablet core: Colloidal silicon dioxide (E 551), magnesium stearate (E 578), mannitol (E 421), microcrystalline cellulose (E 460), povidone (E 1201), pregelatinised starch (maize), sodium starch glycolate (type A).
Danish: - Øvrige indholdsstoffer: Tabletkerne: Kolloid siliciumdioxid (E551), magnesiumstearat (E578), mannitol (E421), mikrokrystallinsk cellulose (E460), povidon (E1201), prægelatiniseret stivelse (majs), natriumstivelsesglykolat (type A).
English: No dose adjustment is necessary in patients with mild or moderate hepatic impairment.
Danish: Dosisjustering er ikke nødvendig for patienter med mild eller moderat leverinsufficiens.
English: Senshio contains lactose.
Danish: Senshio indeholder lactose.
English: 23-24 Tafarnaubach Industrial Estate Tredegar, Gwent, South Wales
Danish: 23-24 Tafarnaubach Industrial Estate
English: Dyspareunia 60 mg OSP Placebo p-value 60 mg OSP Placebo p-value
Danish: 60 mg OSP Placebo p-værdi
English: Common side effects (may affect up to 1 in 10 people): - An infection of the genitals caused by a fungus (thrush) - Hot flushes - Muscle cramps - Vaginal or genital discharge - Rash
Danish: Almindelige bivirkninger (kan forekomme hos op til 1 ud af 10 patienter): - Betændelse i skeden, som skyldes svamp (vaginal trøske) - Hedestigninger - Muskelkramper - Udflåd fra skeden - Udslæt - Hovedpine - Blødning fra skeden
English: Film coating: Hypromellose (E 464), lactose monohydrate, titanium dioxide (E 171), triacetin (E 1518), polyethylene glycol (E 1521).
Danish: Filmovertræk: Hypromellose (E464), lactosemonohydrat, titandioxid (E171), triacetin (E1518), polyethylenglykol (E1521).
English: Gender Senshio is indicated for use only in postmenopausal women.
Danish: Køn Senshio er kun indiceret til brug til postmenopausale kvinder.
English: In bone, ospemifene has agonist-like activity.
Danish: I knogle har ospemifen agonistlignende aktivitet.
English: No cases of endometrial hyperplasia were reported at either time point.
Danish: Der blev ikke rapporteret noget tilfælde af hyperplasi af endometriet hverken ved baseline eller i uge 52.
English: Patients with signs or symptoms of endometrial hyperplasia; safety in this patient group has not been studied.
Danish: Patienter med tegn eller symptomer på endometriehyperplasi.
English: In vitro, ospemifene and 4-hydroxyospemifene inhibited glucuronidation mainly via UGT1A3 and UGT1A9 at clinically relevant concentrations.
Danish: Ospemifen og 4-hydroxyospemifen hæmmede glukuronideringen in vitro primært via UGT1A3 og UGT1A9 ved klinisk relevante koncentrationer.
English: There were no discernible differences in ospemifene plasma concentrations among these groups; however, the influence of race cannot be conclusively determined.
Danish: Der var ingen påviselig forskel i koncentrationen af ospemifen i plasma blandt disse grupper.
English: Periodic safety update reports (PSURs)
Danish: C. ANDRE FORHOLD OG BETINGELSER FOR MARKEDSFØRINGSTILLADELSEN Periodiske, opdaterede sikkerhedsindberetninger (PSUR'er)
English: Senshio is for use only in postmenopausal women.
Danish: Senshio er kun beregnet til brug til postmenopausale kvinder.
English: Relief
Danish: Lindring
English: No dose adjustment is necessary for patients with mild to moderate hepatic impairment.
Danish: Dosisjustering er ikke nødvendig for patienter med let til moderat leverinsufficiens.
English: 5.0% superficial cells in the vaginal smear, a vaginal pH >5.0 and were required to have at least one moderate or severe VVA symptom, where patients had to choose the symptom that was the most bothersome (MBS).
Danish: Studiepopulationen bestod af generelt raske, postmenopausale kvinder i alderen 41 til 80 år (gennemsnitsalder = 59 år), som ved baseline havde ≤ 5,0% overfladiske celler i vaginale celleprøver, et vaginalt pH på >5,0, og kvinderne skulle samtidig have mindst et moderat til svært VVA-symptom, hvor patienten skulle vælge det symptom, som var mest generende (MBS, Most Bothersome Symptom).
English: Senshio 60 mg tablets ospemifene
Danish: Senshio 60 mg tabletter ospemifen
English: Senshio 60 mg film-coated tablets ospemifene
Danish: Senshio 60 mg filmovertrukne tabletter ospemifen
English: Senshio contains sodium
Danish: Senshio indeholder natrium
English: Therefore, caution is recommended when co-administering ospemifene with fluconazole.
Danish: Der bør derfor udvises forsigtighed ved samtidig administration af ospemifen og fluconazol.
English: How to take Senshio
Danish: Sådan skal du tage Senshio
English: - If you have had a stroke (a cerebrovascular accident), or if your doctor has told you that you are at high risk of having one.
Danish: - Hvis du har haft et slagtilfælde, eller hvis din læge har fortalt dig, at du har høj risiko for at få et. - Hvis du lider af andre gynækologiske sygdomme (ud over atrofi af vulva og vagina).
English: Senshio 60 mg film-coated tablets
Danish: Senshio 60 mg filmovertrukket tablet
English: Senshio is not indicated during breast-feeding.
Danish: Senshio er kontraindiceret under amning.
English: All patients received non-hormonal vaginal lubricant for use as needed; therefore, the effects on efficacy endpoints in the ospemifene treatment group were in addition to those achieved with lubricant use alone.
Danish: Derfor var virkningen i virkningsendepunkterne i den ospemifen-behandlede gruppe i tillæg til dem, som blev opnået ved brug af glidecreme alene.
English: Colloidal silicon dioxide (E 551) Magnesium stearate (E 578) Mannitol (E 421) Microcrystalline cellulose (E 460) Povidone (E 1201) Pregelatinised starch (maize) Sodium starch glycolate (type A)
Danish: Mikrokrystallinsk cellulose (E 460) Povidon (E 1201) Prægelatiniseret stivelse (majs) Natriumstivelsesglykolat (type A)
English: - Headache - Vaginal bleeding
Danish: Vaginalt udflåd, udflåd fra skeden, vaginal blødning
English: Renal impairment
Danish: Pruritus Urticaria
English: What Senshio is and what it is used for What you need to know before you take Senshio How to take Senshio
Danish: Det skal du vide, før du begynder at tage Senshio Sådan skal du tage Senshio Bivirkninger
English: Dryness
Danish: Amning
English: In in vitro studies ospemifene is a weak inhibitor for CYP2B6, CYP2C9, CYP2C19, CYP2C8 and CYP2D6.
Danish: Ospemifen og 4-hydroxyospemifen hæmmede glukuronideringen in vitro via UGT1A3 og UGT1A9 ved klinisk relevante koncentrationer, I in vitro undersøgelser er ospemifen en svag hæmmer af CYP2B6, CYP2C9, CYP2C19, CYP2C8 og CYP2D6.
English: Posology
Danish: Hovedpinec