FrancophonIA/ELRC3.0 huggingface dataset:
English: When there is also a potential for voriconazole to increase the plasma concentrations of substances metabolised by CYP3A4 isoenzymes (certain antihistamines, quinidine, cisapride, pimozide), co-administration is contraindicated (see below and section 4.3).
Croatian: Istodobna je primjena kontraindicirana kada postoji mogućnost da će vorikonazol povećati plazmatske koncentracije lijekova koji se metaboliziraju pomoću izoenzima CYP3A4 (određeni antihistaminici, kinidin, cisaprid, pimozid), (vidjeti u nastavku i dio 4.3).
English: The findings of the effect of efavirenz on voriconazole suggest that the metabolism of voriconazole may be induced by a NNRTI.
Croatian: Nalazi o učinku efavirenza na vorikonazol upućuju na to NNRTI može inducirati metabolizam vorikonazola.
English: General disorders and administration site conditions pyrexia chest pain, face oedema11, asthenia, chills infusion site reaction, influenza like illness
Croatian: Opći poremećaji i reakcije na mjestu primjene pireksija bol u prsištu, edem lica11, astenija, zimica reakcija na mjestu injekcije, bolest nalik gripi
English: Co-administration with sirolimus, since voriconazole is likely to increase plasma concentrations of sirolimus significantly (see section 4.5).
Croatian: Istodobna primjena sa sirolimusom, jer će vorikonazol vjerojatno dovesti do značajnog povećanja koncentracije sirolimusa u plazmi (vidjeti dio 4.5.).
English: Voriconazole (N=98)
Croatian: Vorikonazol (N=98)
English: Voriconazole Hikma 200 mg powder for solution for infusion is for intravenous use only.
Croatian: Vorikonazol Hikma 200 mg prašak za otopinu za infuziju je namijenjen samo za intravensku primjenu.
English: When voriconazole treatment is stopped, the initial dose of efavirenz should be restored (see section 4.2 and 4.4).
Croatian: Kad se prekine liječenje vorikonazolom, treba se vratiti na početnu dozu efavirenza (vidjeti dijelove 4.2 i 4.4).
English: Omeprazole (40 mg QD)* [CYP2C19 inhibitor; CYP2C19 and CYP3A4 substrate]
Croatian: Omeprazol (40 mg QD)* [inhibitor CYP2C19; supstrat CYP2C19 i CYP3A4]
English: Ritonavir Cmax and AUCτ ↔ Voriconazole Cmax ↓ 66% Voriconazole AUCτ ↓ 82%
Croatian: Ritonavir Cmax i AUCτ↔ Vorikonazol Cmax ↓66% Vorikonazol AUCτ ↓ 82%
English: In vitro studies show that the metabolism of voriconazole may be inhibited by NNRTIs and voriconazole may inhibit the metabolism of NNRTIs.
Croatian: Ispitivanja in vitro pokazuju da NNRTI-i mogu inhibirati metabolizam vorikonazola kao i da vorikonazol može inhibirati metabolizam NNRTI-ja.
English: Fluconazole (200 mg QD) [CYP2C9, CYP2C19 and CYP3A4 inhibitor]
Croatian: Flukonazol (200 mg QD) [inhibitor CYP2C9, CYP2C19 I CYP3A4]
English: Phenytoin Cmax ↑ 67% Phenytoin AUCτ ↑ 81% Compared to voriconazole 200 mg BID,
Croatian: Fenitoin Cmax ↑67% Fenitoin AUCτ ↑81% U usporedbi s dozom vorikonazola od 200 mg
English: In the pre and postnatal development study in rats at exposures lower than those obtained in humans with therapeutic doses, voriconazole prolonged the duration of gestation and labour and produced dystocia with consequent maternal mortality and reduced perinatal survival of pups.
Croatian: U ispitivanjima reproduktivne toksičnosti vorikonazol se pokazao teratogenim u štakora te embriotoksičnim u kunića, pri sustavnoj izloženosti jednakoj onoj koja se postiže u ljudi primjenom terapijskih doza.U istraživanjima prenatalnog i postnatalnog razvoja na štakorima, pri nižim razinama izloženosti od onih koje se postižu primjenom terapijskih doza u ljudi, vorikonazol je produljio gestacijski period i trajanje okota, uz otežan okot koji je za posljedicu imao veći mortalitet majki i manje perinatalno preživljenje mladunčadi.
English: Voriconazole Cmax and AUCτ ↔ The effect of voriconazole on either erythromycin or azithromycin is unknown.
Croatian: ↔ Nije poznat učinak vorikonazola ni na eritromicin ni na azitromicin.
English: If you stop taking Voriconazole Hikma
Croatian: Ako prestanete primati Vorikonazol Hikma
English: Indinavir (800 mg TID) [CYP3A4 inhibitor and substrate]
Croatian: Indinavir (800 mg TID) [inhibitor i supstrat CYP3A4]
English: Voriconazole Hikma powder for solution for infusion needs to first be reconstituted with either 19 ml of water for injections or 19 ml of sodium chloride 9 mg/ml (0.9%) solution for injection to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml voriconazole.
Croatian: Hikma prašak za otopinu za infuziju se najprije mora pripremiti za primjenu ili s 19 ml vode za injekcije ili s 19 ml otopine natrijevog klorida za injekciju od 9 mg/ml (0,9%) kako bi se dobio iskoristivi volumen od 20 ml bistrog koncentrata koji sadrži 10 mg/ml vorikonazola.
English: If patient response to treatment is inadequate, the intravenous dose may be increased by 1 mg/kg steps.
Croatian: Ako bolesnik ne postiže zadovoljavajući odgovor na liječenje, doza se može povećavati u koracima od 1 mg/kg.
English: As you will be given this medicine under close medical supervision, it is unlikely that a dose would be missed.
Croatian: Ako se zaboravi primijeniti doza lijeka Vorikonazol Hikma Budući da ćete ovaj lijek primati pod strogim nadzorom liječnika, nije vjerojatno da ćete propustiti dozu.
English: Patients should be monitored for the development of abnormal renal function.
Croatian: Bolesnike treba nadzirati zbog mogućeg poremećaja bubrežne funkcije.
English: Methadone (CYP3A4 substrate)
Croatian: Metadon (supstrat CYP3A4)
English: Electrolyte disturbances such as hypokalaemia, hypomagnesaemia and hypocalcaemia should be monitored and corrected, if necessary, prior to initiation and during voriconazole therapy (see section 4.4).
Croatian: Poremećaje elektrolita poput hipokalemije, hipomagnezemije i hipokalcemije treba nadzirati i po potrebi korigirati prije započinjanja i tijekom liječenja vorikonazolom (vidjeti dio 4.4).
English: Concomitant use of voriconazole and phenytoin should be avoided unless the benefit outweighs the risk (see section 4.5).
Croatian: Treba izbjegavati istodobnu primjenu vorikonazola i fenitoina, osim u slučajevima kada korist nadilazi rizik (vidjeti dio 4.5).
English: This medicinal product is for single use only and any unused solution should be discarded and only clear solutions without particles should be used.
Croatian: Smije se upotrijebiti samo bistra otopina bez vidljivih čestica.
English: It is recommended that a standard 20 ml (non-automated) syringe be used to ensure that the exact amount (19.0 ml) of water for injections or of sodium chloride 9 mg/ml (0.9%) solution for injection is dispensed.
Croatian: Preporučuje se uporaba standardne (neautomatizirane) štrcaljke od 20 ml, kako bi se osiguralo odmjeravanje točne količine (19,0 ml) vode za injekcije ili otopine natrijevog klorida za injekciju od 9 mg/ml (0,9%).
English: Detailed information on dosage recommendations is provided in the following table:
Croatian: Detaljne upute o preporučenom doziranju nalaze se u sljedećoj tablici: Peroralno*
English: Hepatobiliary disorders liver function test abnormal jaundice, jaundice cholestatic, hepatitis10
Croatian: Poremećaji jetre i žuči abnormalne vrijednosti testova žutica, žutica kolestatska, hepatitis10
English: Larger inter-subject variability was observed in paediatric patients compared to adults.
Croatian: U usporedbi s odraslima, u pedijatrijskih je bolesnika zabilježena veća varijabilnost između ispitanika.
English: After reconstitution with 19 ml of water for injections or sodium chloride 9 mg/ml (0.9%) solution for injection, a clear solution is obtained.
Croatian: Nakon pripreme s 19 ml vode za injekcije ili otopine natrijevog klorida za injekciju od 9 mg/ml (0,9%) dobiva se bistra otopina.
English: Vinca Alkaloids (e.g., vincristine and vinblastine) [CYP3A4 substrates]
Croatian: Vinka alkaloidi (npr. vinkristin i vinblastin) [supstrati CYP3A4]
English: Dose reduction in oxycodone and other long-acting opiates metabolized by CYP3A4 (e.g., hydrocodone) should be considered.
Croatian: Treba razmotriti smanjenje doze oksikodona i drugih opijata dugog djelovanja koji se metaboliziraju pomoću CYP3A4 (npr. hidrokodon).
English: Although not studied, voriconazole is likely to significantly increase the plasma concentrations of everolimus.
Croatian: Iako nije ispitivano, vorikonazol će vjerojatno značajno povisiti koncentracije everolimusa u plazmi.
English: Hepatic toxicity
Croatian: Hepatotoksičnost
English: Skin rashes which may lead to severe blistering and peeling of the skin characterized by a flat, red area on the skin that is covered with small confluent bumps, redness of the skin
Croatian: Kožni osipi koji mogu dovesti do jakog stvaranja mjehurića i ljuštenja kože karakterizirano ravnim, crvenim područjem kože koje je prekriveno malim izraslinama koje se spajaju, crvenilo kože - svrbež - gubitak kose - bol u leđima - zatajenje bubrega, krv u mokraći, promjene u testovima funkcije bubrega.
English: IFI while on study drug * Primary endpoint of the study ** Difference in proportions, 95% CI and p-values obtained after adjustment for randomization
Croatian: * Primarni ishod ispitivanja ** Razlika u udjelima, 95%-tni CI i p-vrijednosti dobivene nakon prilagodbe za randomizaciju
English: Everolimus [CYP3A4 substrate, P-gp substrate]
Croatian: Everolimus [supstrat CYP3A4, supstrat P-glikoproteina]
English: Although not studied clinically, voriconazole is likely to increase the plasma concentrations of benzodiazepines that are metabolised by CYP3A4 and lead to a prolonged sedative effect.
Croatian: Iako ova interakcija nije klinički ispitana, vorikonazol će vjerojatno povisiti plazmatske koncentracije benzodiazepina koji se metaboliziraju putem CYP3A4 i time produljiti sedativni učinak
English: Although not studied clinically, voriconazole is likely to increase the plasma concentrations of statins that are metabolised by CYP3A4 and could lead to rhabdomyolysis.
Croatian: Iako ova interakcija nije klinički ispitana, vorikonazol će vjerojatno povisiti plazmatske koncentracije statina koji se metaboliziraju putem CYP3A4, što može dovesti do rabdomiolize.
English: Concomitant use of voriconazole and phenytoin should be avoided unless the benefit outweighs the risk.
Croatian: Istodobnu primjenu vorikonazola i fenitoina treba izbjegavati, osim kad korist nadilazi rizik liječenja.
English: 6 mg/kg every 12 hours for the first 24 hours
Croatian: 6 mg/kg svakih 12 sati tijekom prva 24 sata
English: In vitro studies showed that voriconazole is metabolised by the hepatic cytochrome P450 isoenzymes, CYP2C19, CYP2C9 and CYP3A4.
Croatian: Ispitivanja in vitro pokazala su da se vorikonazol metabolizira pomoću jetrenih izoenzima citokroma P450, i to CYP2C19, CYP2C9 i CYP3A4.
English: Voriconazole Cmax ↑ 34% Voriconazole AUCτ ↑ 39%
Croatian: Vorikonazol Cmax ↑34% Vorikonazol AUCτ ↑39%
English: The oral maintenance dose of 200 mg (or 100 mg for patients less than 40 kg) achieves a voriconazole exposure similar to 3 mg/kg IV. A 300 mg (or 150 mg for patients less than 40 kg) oral maintenance dose achieves an exposure similar to 4 mg/kg IV.
Croatian: Peroralnom dozom održavanja od 300 mg (ili 150 mg za bolesnike tjelesne težine manje od 40 kg) postiže se podjednaka izloženost kao kod intravenske primjene doze od 4 mg/kg.
English: Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder
Croatian: Nositelj odobrenja za stavljanje gotovog lijeka u promet i proizvođač Nositelj odobrenja za stavljanje gotovog lijeka u promet
English: 4 mg/kg twice daily 200 mg twice daily
Croatian: 4 mg/kg dvaput na dan 200 mg dvaput na dan 100 mg dvaput na dan
English: Monitoring for voriconazoleassociated adverse reactions is recommended if voriconazole is used sequentially after fluconazole.
Croatian: Preporučuje se nadzor kako bi se uočile nuspojave povezane s vorikonazolom ako se vorikonazol primjenjuje nakon liječenja flukonazolom.
English: 11 Includes periorbital oedema, lip oedema, and oedema mouth.
Croatian: 11 Uključuje periorbitalni edem, edem usana i usne šupljine.
English: A placebo-controlled, randomized, single-dose, crossover study to evaluate the effect on the QTc interval of healthy volunteers was conducted with three oral doses of voriconazole and ketoconazole.
Croatian: Klinička ispitivanja u kojima je ispitivan QTc-interval U placebom kontroliranom, randomiziranom, ukrižanom ispitivanju s primjenom jednokratne doze lijeka praćen je učinak lijeka na QTc-interval u zdravih dobrovoljaca.
English: 9 mg/kg every 12 hours for the first 24 hours
Croatian: 9 mg/kg svakih 12 sati tijekom prva 24 sata
English: Ear and labyrinth disorders hypoacusis, vertigo, tinnitus
Croatian: Poremećaji uha i labirinta hipoakuzija, vrtoglavica, tinitus
English: If a patient develops a rash he should be monitored closely and VORICONAZOLE HIKMA discontinued if lesions progress.
Croatian: Ako se u bolesnika pojavi osip, treba ga pomno nadzirati te prekinuti primjenu Vorikonazola Hikma u slučaju progresije lezija.
English: 12 weeks after EOT
Croatian: 12 tjedana po završetku liječenja
English: While being treated with Voriconazole Hikma:
Croatian: Za vrijeme liječenja lijekom Vorikonazol Hikma:
English: Prednisolone (60 mg single dose) [CYP3A4 substrate]
Croatian: Prednizolon (jedna doza od 60 mg) [supstrat CYP3A4]
English: Prednisolone Cmax ↑ 11% Prednisolone AUC0-∞ ↑ 34%
Croatian: Prednizolon Cmax ↑11% Prednizolon AUC0-∞↑34%
English: Voriconazole Hikma is intended for patients with worsening, possibly life-threatening, fungal infections.
Croatian: Hikma je namijenjen bolesnicima s gljivičnim infekcijama koje se pogoršavaju, a mogu biti opasne po život.
English: Once reconstituted further dilution is required before administration.
Croatian: Pripremljenu otopinu prije primjene treba dodatno razrijediti.
English: Voriconazole Hikma is an antifungal medicine.
Croatian: Vorikonazol Hikma je lijek za liječenje gljivičnih infekcija.
English: In an independent published study, Alfentanil AUC∞ ↑ 6-fold
Croatian: Alfentanil AUC0-∞↑6 puta
English: In an independent published study, Sirolimus Cmax ↑ 6.6-fold Sirolimus AUC0-∞ ↑ 11-fold
Croatian: Sirolimus Cmax ↑6,6 puta Sirolimus AUC0-∞↑11 puta
English: Single use vial
Croatian: Bočica za jednokratnu uporabu.
English: Oral voriconazole should be administered to these patients, unless an assessment of the risk benefit to the patient justifies the use of intravenous voriconazole.
Croatian: U tih bolesnika vorikonazol treba primijeniti peroralnim putem, osim ako omjer rizika i koristi ne opravdava intravensku primjenu lijeka.
English: Some medicines, when taken at the same time as Voriconazole Hikma, may affect the way that Voriconazole Hikma works or Voriconazole Hikma may affect the way they work.
Croatian: Kada se primjenjuju istodobno s lijekom Vorikonazol Hikma, neki lijekovi mogu utjecati na djelovanje lijeka Vorikonazol Hikma, ali i Vorikonazol
English: The powder is reconstituted with either 19 ml of water for injections or 19 ml of sodium chloride 9 mg/ml (0.9%) solution for injection to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml of voriconazole.
Croatian: Prašak se priprema za primjenu ili s 19 ml vode za injekcije ili s 19 ml otopine natrijevog klorida za injekciju od 9 mg/ml (0,9%), kako bi se dobio iskoristivi volumen od 20 ml bistrog koncentrata koji sadrži 10 mg/ml vorikonazola.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Voriconazole Hikma 200 mg powder for infusion Voriconazole
Croatian: NAZIV LIJEKA I PUT(EVI) PRIMJENE LIJEKA Vorikonazol Hikma 200 mg prašak za infuziju vorikonazol
English: General pharmacokinetic characteristics
Croatian: Opća farmakokinetička obilježja
English: 300 mg QD (co-administered with voriconazole 350 mg BID)*
Croatian: 300 mg QD (primijenjeno istodobno s vorikonazolom u dozi od 350 mg BID)*
English: Reduction in the dose of oxycodone and other long-acting opiates metabolized by CYP3A4 (e.g., hydrocodone) should be considered when coadministered with voriconazole.
Croatian: Treba razmotriti smanjenje doze oksikodona i drugih opijata dugog djelovanja koji se metaboliziraju putem CYP3A4 (npr. hidrokodon) kada se primjenjuju istodobno s vorikonazolom.
English: Skin and subcutaneous tissue disorders rash dermatitis exfoliative, alopecia, rash maculo-papular, pruritus, erythema
Croatian: Poremećaji kože i potkožnog tkiva osip eksfolijativni dermatitis, alopecija, makulopapulozni osip, pruritus, eritem
English: If you or your child develops skin disorders, your doctor may refer you to a dermatologist, who after consultation may decide that it is important for you or your child to be seen on a regular basis.
Croatian: Opekotine od sunca ili teška kožna reakcija uslijed izlaganja svjetlosti ili suncu nastale su češće u djece Ako Vi ili Vaše dijete primijetite promjene na koži, Vaš liječnik može Vas uputiti dermatologu, koji nakon pregleda može ustanoviti da je važno da Vi ili Vaše dijete redovito dolazite na kontrolu.
English: unspecified (including cysts and polyps) Blood and lymphatic system disorders agranulocytosis1, pancytopenia, thrombocytopenia2, leukopenia, anaemia bone marrow failure, lymphadenopathy, eosinophilia disseminated intravascular coagulation
Croatian: Poremećaji krvi i limfnog sustava agranulocitoza1, pancitopenija, trombocitopenija 2, leukopenija, anemija zatajenje koštane srži, limfadenopatija, eozinofilija diseminirana intravaskularna koagulacija
English: S-Ibuprofen Cmax ↑ 20% S-Ibuprofen AUC0-∞ ↑ 100%
Croatian: S-ibuprofen Cmax ↑20% S-ibuprofen AUC0-∞ ↑100% Diklofenak Cmax ↑114% Diklofenak AUC0-∞↑78%
English: : Seven (3 complete, 4 partial responses) of 17 patients were successfully treated with voriconazole.
Croatian: Vrsta iz roda Fusarium: Sedam od ukupno 17 bolesnika liječenih vorikonazolom uspješno je odgovorilo na terapiju (3 potpuna, 4 djelomična odgovora).
English: Visual adverse reactions
Croatian: Kožne reakcije
English: Co-administration with high dose ritonavir (400 mg and above twice daily) because ritonavir significantly decreases plasma voriconazole concentrations in healthy subjects at this dose.
Croatian: Istodobna primjena s visokom dozom ritonavira (400 mg i više dvaput na dan), jer ritonavir u toj dozi značajno smanjuje koncentraciju vorikonazola u plazmi zdravih ispitanika (vidjeti dio 4.5; za manje doze vidjeti dio 4.4).
English: The predicted total exposures in children following IV maintenance doses of 4 and 8 mg/kg twice daily were comparable to those in adults following 3 and 4 mg/kg IV twice daily, respectively.
Croatian: Predviđena ukupna izloženost u djece nakon i.v. primjene doze održavanja od 4 mg/kg dvaput na dan bila je usporediva s onom u odraslih nakon i.v. primjene 3 mg/kg dvaput na dan, dok je izloženost u djece nakon i.v. primjene doze od 8 mg/kg dvaput na dan bila usporediva s onom u odraslih nakon i.v. primjene doze od 4 mg/kg dvaput na dan.
English: Reconstitute and dilute before use - see leaflet.
Croatian: Prije primjene potrebno je pripremiti i razrijediti - vidjeti Uputu o lijeku.
English: Survived to day 180
Croatian: Stopa preživljenja na 180.
English: It is recommended that the standard loading dose regimens be used but that the maintenance dose be halved in patients with mild to moderate hepatic cirrhosis (Child-Pugh A and B) receiving voriconazole (see section
Croatian: Preporučuje se da se u bolesnika s blagom do umjerenom cirozom jetre (Child-Pugh stadij A i B) koji dobivaju vorikonazol liječenje započne standardnom udarnom dozom, no da se doza održavanja prepolovi (vidjeti dio 5.2).
English: - If you get any side effects, talk to your doctor,pharmacist or nurse.
Croatian: - Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika, ljekarnika ili medicinsku sestru.
English: Ritonavir (protease inhibitor) [potent CYP450 inducer; CYP3A4 inhibitor and substrate] High dose (400 mg BID)
Croatian: Ritonavir (inhibitor proteaze) [snažan induktor CYP450; inhibitor i supstrat CYP3A4]
English: Although not studied, voriconazole may increase the plasma concentrations of coumarins that may cause an increase in prothrombin time.
Croatian: Iako nije ispitivano, vorikonazol može povisiti koncentracije kumarina u plazmi, što može produljiti protrombinsko vrijeme.
English: Monitoring of hepatic function
Croatian: Nadzor bubrežne funkcije
English: 6 weeks after EOT
Croatian: 6 tjedana po završetku liječenja
English: Voriconazole Cmax ↑ 18% Voriconazole AUCτ ↑ 23%
Croatian: Vorikonazol Cmax ↑18% Vorikonazol AUCτ ↑23%
English: The recommended dosing regimen is as follows:
Croatian: Preporučeni režim doziranja je kako slijedi: Intravenski
English: This includes cases of jaundice, hepatitis and hepatic failure leading to death (see section 4.4).
Croatian: Tu se ubrajaju slučajevi žutice, hepatitisa i zatajenja jetre sa smrtnim ishodom (vidjeti dio
English: Monitoring of renal function
Croatian: Nadzor funkcije gušterače
English: There have been post-marketing reports of prolonged visual adverse events (see section 4.4).
Croatian: Nakon što je lijek stavljen u promet bile su prijavljene produljene nuspojave vida (vidjeti dio 4.4).
English: Reactions during the infusion have occurred uncommonly with Voriconazole Hikma (including flushing, fever, sweating, increased heart rate and shortness of breath).
Croatian: Hikma su se manje često javile reakcije tijekom infuzije (uključujući crvenilo praćeno osjećajem užarenosti, vrućicu, znojenje, ubrzani puls i nedostatak zraka).
English: You may be switched from the intravenous infusion to tablets once your condition improves.
Croatian: Nakon što Vam se stanje poboljša, možda ćete umjesto infuzije u venu ovaj lijek uzimati u obliku tableta.
English: Reduction in the dose of alfentanil, fentanyl and other short acting opiates similar in structure to alfentanil and metabolised by CYP3A4 (e.g., sufentanil) should be considered when co-administered with voriconazole (see section 4.5).
Croatian: Kada se primjenjuju istodobno s vorikonazolom, treba razmotriti smanjenje doze alfentanila, fentanila i ostalih kratkodjelujućih opijata koji imaju strukturu sličnu alfentanilu i metaboliziraju se pomoću CYP3A4 (npr. sufentanil) (vidjeti dio 4.5).
English: • serious invasive Candida sp. infections when the fungus is resistant to fluconazole (another antifungal medicine),
Croatian: • ozbiljne invazivne infekcije uzrokovane vrstama iz roda Candida kada je gljivica otporna na flukonazol
English: Renal and urinary disorders renal failure acute, haematuria renal tubular necrosis, proteinuria, nephritis
Croatian: Poremećaji bubrega i mokraćnog sustava akutno zatajenje bubrega, hematurija bubrežna tubularna nekroza, proteinurija, nefritis
English: • Allergic skin reactions (sometimes severe), including life-threatening skin condition that causes painful blisters and sores of the skin and mucous membranes, especially in the mouth inflammation of the skin hives, sunburn or severe skin reaction following exposure to light or sun,
Croatian: - alergijska reakcija opasna po život - poremećaj u zgrušavanju krvi - alergijska reakcija kože (katkad ozbiljna), uključujući brzo oticanje (edem) kože, potkožnog tkiva, sluzokože i podsluzokože, svrab ili bolni dijelovi debele, crvene kože sa srebrnastim kožnim ljuskicama, nadraženost kože i sluzokože, kožna stanja opasna po život koja uzrokuju odvajanje velikih površina epidermisa, gornjeg sloja kože, od donjih dijelova kože
English: • Cisapride (used for stomach problems)
Croatian: • cisaprid (koristi se za ublažavanje želučanih tegoba)
English: Voriconazole Hikma must not be infused into the same line or cannula concomitantly with other intravenous products.
Croatian: Hikma se ne smije infundirati istodobno s drugim lijekovima u istoj infuzijskoj liniji ili kanili.
English: • Phenytoin (used to treat epilepsy).
Croatian: • fenitoin (koristi se za liječenje epilepsije).
English: retinal haemorrhage optic nerve disorder7, papilloedema8, oculogyric crisis, diplopia, scleritis, blepharitis optic atrophy, corneal opacity
Croatian: krvarenje u retini poremećaj vidnog živca7, papiloedem8, okulogirična kriza, diplopija, skleritis, blefaritis atrofija vidnog živca, zamućenje rožnice
English: • Ciclosporin (used in transplant patients)
Croatian: • ciklosporin (koristi se u bolesnika s presatkom organa)