FrancophonIA/ELRC3.0 huggingface dataset:
English: Only clear solution without particles should be used.
Croatian: Smije se koristiti samo bistra otopina bez čestica.
English: Gender Bioavailability and pharmacokinetics of ibandronic acid are similar in both men and women.
Croatian: Bioraspoloživost i farmakokinetika ibandronatne kiseline su slični u žena i muškaraca.
English: Mean Cmax was not increased in patients with mild renal impairment and increased by 12% in patients with moderate renal impairment.
Croatian: Srednja vrijednost Cmax nije bila povećana u bolesnika s blagim oštećenjem bubrega, a bila je povećana za 12% u bolesnika s umjerenim oštećenjem bubrega.
English: There are no data available characterising the use of a shorter infusion time in patients with creatinine clearance below 50 ml/min.
Croatian: Nema dostupnih podataka koji bi karakterizirali primjenu kraćeg vremena trajanja infuzije u bolesnika s klirensom kreatinina nižim od 50 ml/min.
English: Taking medicines that reduce stomach acid such as cimetidine and ranitidine, may slightly increase the effects of Iasibon.
Croatian: Uzimanje lijekova za smanjenje kiseline u želucu poput cimetidina i ranitidina može neznatno povećati učinak lijeka Iasibon.
English: Iasibon tablets contain lactose and should not be administered to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Croatian: Rijetki nasljedni poremećaji Iasibon tablete sadrže laktozu i ne smiju se davati bolesnicima s rijetkim nasljednim poremećajima nepodnošenja galaktoze, deficijencije Lapp laktaze ili malapsorpcije glukoze-galaktoze.
English: The results from this trial are summarised below.
Croatian: U nastavku su navedeni rezultati ovog ispitivanja.
English: In the dose range recommended for treatment, the following response rates with the respective confidence intervals have been shown in clinical trials for patients with baseline albumin-corrected serum calcium ≥ 3.0 mmol/l after adequate rehydration.
Croatian: U rasponu doza preporučenih za liječenje, sljedeće stope odgovora s pripadajućim intervalima pouzdanosti uočene su u kliničkim ispitivanjima bolesnika s početnom razinom kalcija u serumu korigiranog albuminom od ≥3,0 mmol/l nakon odgovarajuće rehidracije.
English: Ibandronic acid dose
Croatian: Doza ibandronatne kiseline
English: • itching or tingling skin (paraesthesia)
Croatian: • svrbež ili trnci kože (parestezija)
English: Up to now there is no experience of acute poisoning with Iasibon concentrate for solution for infusion.
Croatian: Do sada nije bilo slučajeva akutnog trovanja Iasibon koncentratom za otopinu za infuziju.
English: Because of these possible irritant effects and a potential for worsening of the underlying disease, caution should be used when Iasibon is given to patients with active upper gastrointestinal problems (e.g. known Barrett's oesophagus, dysphagia, other oesophageal diseases, gastritis, duodenitis or ulcers).
Croatian: Zbog pojave ovih mogućih iritacija i mogućnosti pogoršanja osnovne bolesti, potreban je oprez kad se Iasibon propisuje bolesnicima s problemima gornjeg dijela gastrointestinalnog sustava (na primjer Barrettov jednjak, disfagija, druge bolesti jednjaka, gastritis, upala dvanaesnika ili vrijedovi).
English: • acetylsalicylic acid and non-steroidal anti-inflammatory medicines called “NSAIDs”, such as, ibuprofen or naproxen.
Croatian: • acetilsalicilatnu kiselinu i nesteroidne protuupalne lijekove (NSAR) kao što su ibuprofen i naproksen.
English: These fractures occur after minimal or no trauma and some patients experience thigh or groin pain, often associated with imaging features of stress fractures, weeks to months before presenting with a completed femoral fracture.
Croatian: Ovi prijelomi nastaju uslijed neznatne traume ili bez traume, dok su neki bolesnici osjećali bol u bedrima ili preponama, koja je često bila povezana sa snimkama stres-fraktura, tjednima, pa čak i mjesecima prije kliničke slike potpunoga prijeloma bedrene kosti.
English: Frequency categories are defined using the following convention: very common (>1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare
Croatian: Kategorije učestalosti definirane su na sljedeći način: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: For patients who develop osteonecrosis of the jaw while on bisphosphonate therapy, dental surgery may exacerbate the condition.
Croatian: U bolesnika u kojih se osteonekroza čeljusti pojavi tijekom liječenja bisfosfonatima operacija na zubima bi mogla pogoršati stanje.
English: This is because NSAIDs and Iasibon can both irritate your stomach and gut
Croatian: To je važno stoga što i NSAR i Iasibon mogu uzrokovati nadražaj želuca i crijeva
English: You may have early signs of a possible unusual fracture of the thigh bone.
Croatian: To mogu biti rani znakovi mogućeg neuobičajenog prijeloma bedrene kosti.
English: Ibandronate 6 mg n=154
Croatian: ibandronat 6 mg n=154
English: Also, some other medicines can affect the way Iasibon works.
Croatian: Također, drugi lijekovi mogu utjecati na djelovanje lijeka Iasibon.
English: • sleep problems, feeling anxious, emotional instability, or mood swings
Croatian: • poremećaj spavanja, osjećaj tjeskobe, emotivna nestabilnost ili promjene raspoloženja
English: No specific information is available on the treatment of overdosage with Iasibon.
Croatian: Nisu dostupne specifične informacije o liječenju u slučaju predoziranja lijekom Iasibon.
English: It is recommended that the product once diluted be used immediately (see point 5 of this leaflet “How to store Iasibon”).
Croatian: Preporučuje se da se lijek upotrijebi odmah nakon razrjeđivanja (pogledajte dio 5. ove upute o lijeku, “Kako čuvati Iasibon”).
English: Decreased renal calcium excretion may be accompanied by a fall in serum phosphate levels not requiring therapeutic measures.
Croatian: Smanjeno bubrežno izlučivanje kalcija može biti popraćeno padom razine fosfata u serumu koji ne zahtijeva terapijske mjere.
English: Cerebrovascular disorder, nerve root lesion , amnesia, migraine, neuralgia, hypertonia, hyperaestesia, paraesthesia circumoral, parosmia
Croatian: cerebrovaskularni poremećaj, lezija korijena živca, amnezija, migrena, neuralgija, hipertonija, hiperestezija, cirkumoralna parestezija, parosmija
English: Clinical studies have not shown any evidence of deterioration in renal function with long term Iasibon therapy.
Croatian: U kliničkim ispitivanjima nije bilo dokaza pogoršanja bubrežne funkcije tijekom dugotrajne terapije lijekom Iasibon.
English: Ask your doctor or pharmacist for advice before taking this medicine.
Croatian: Obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: Ibandronic acid selectively inhibits osteoclast activity, reducing bone resorption and thereby reducing skeletal complications of the malignant disease.
Croatian: Ibandronatna kiselina selektivno inhibira aktivnost osteoklasta, smanjujući resorpciju kostiju i time smanjuje koštane komplikacije zloćudne bolesti.
English: Female patients with breast cancer and radiologically confirmed bone metastases were randomised to receive placebo (158 patients) or 6 mg Ibandronate (154 patients).
Croatian: Bolesnice s rakom dojke i radiološki potvrđenim koštanim metastazama randomizirane su za primanje placeba (158 bolesnica) ili 6 mg ibandronata (154 bolesnica).
English: Paediatric population (see section 4.2 and section 5.1) There are no data on the use of Iasibon in patients less than 18 years old.
Croatian: Pedijatrijska populacija (vidjeti dijelove 4.2 i 5.1) Ne postoje podaci o primjeni lijeka Iasibon u bolesnika mlađih od 18 godina.
English: • changes in your blood cells (‘anaemia')
Croatian: • promjena broja krvnih stanica (anemija)
English: The medicine should be administered as an infusion in your vein over two hours.
Croatian: Lijek se daje u obliku infuzije u venu, u trajanju od 2 sata.
English: Milk or antacids should be given to bind Iasibon.
Croatian: Potrebno je uzeti mlijeko ili antacide kako bi se Iasibon vezao.
English: • if you are allergic to ibandronic acid or any of the other ingredients of this medicine that are listed in section 6
Croatian: • ako ste alergični na ibandronatnu kiselinu ili neki drugi sastojak ovog lijeka naveden u dijelu 6
English: • if you are having dental treatment or surgery or know that you need some in the future, tell your dentist that you are being treated with Iasibon for cancer
Croatian: • ako liječite zube ili imate operaciju na zubima ili znate da ćete nešto od toga trebati u budućnosti, obavijestite svog stomatologa da se liječite lijekom Iasibon zbog raka.
English: Female patients with breast cancer and radiologically confirmed bone metastases were randomised to receive placebo (277 patients) or 50 mg Ibandronate (287 patients).
Croatian: Bolesnice s rakom dojke i radiološki potvrđenim koštanim metastazama randomizirane su za primanje placeba (277 bolesnica) ili 50 mg ibandronata (287 bolesnica).
English: Clinical studies in the treatment of tumour-induced hypercalcaemia Clinical studies in hypercalcaemia of malignancy demonstrated that the inhibitory effect of ibandronic acid on tumour-induced osteolysis, and specifically on tumour-induced hypercalcaemia, is characterised by a decrease in serum calcium and urinary calcium excretion.
Croatian: Klinička ispitivanja u liječenju hiperkalcijemije nastale zbog tumora Klinička ispitivanja hiperkalcijemije povezane sa zloćudnim bolestima pokazala su da je inhibitorni učinak ibandronatne kiseline na osteolizu uzrokovanu tumorom, a osobito hiperkalcijemiju uzrokovanu tumorom, karakteriziran smanjenjem kalcija u serumu i izlučivanjem kalcija urinom.
English: Urinary concentrations of the bone resorption marker CTx (C-terminal telopeptide released from Type I collagen) were significantly reduced in the Ibandronate group compared to placebo.
Croatian: Koncentracije biljega resorpcije kostiju CTx (C-terminalni telopeptid otpušten iz kolagena tipa I) u urinu bile su znatno smanjene u grupi koja je primala ibandronat u usporedbi s placebo grupom.
English: Patients with cardiac impairment Overhydration should be avoided in patients at risk of cardiac failure.
Croatian: Treba izbjegavati prekomjernu hidraciju u bolesnika u kojih postoji rizik od zatajenja srca.
English: • feeling thirsty, sore throat, changes in taste
Croatian: • osjećaj žeđi, grlobolja, promjene osjeta okusa
English: Metabolic interactions are not considered likely, since ibandronic acid does not inhibit the major human hepatic P450 isoenzymes and has been shown not to induce the hepatic cytochrome P450 system in rats (see section 5.2).
Croatian: Smatra se da metaboličke interakcije s lijekovima nisu vjerojatne s obzirom da ibandronatna kiselina ne inhibira glavne jetrene izoenzime P450 u ljudi i ne inducira jetreni P450 citokromski sustav u štakora (vidjeti dio 5.2).
English: Diagnosis of cancer, chemotherapy, radiotherapy, corticosteroids and poor oral hygiene are also deemed as risk factors (see section 4.4).
Croatian: Rak, kemoterapija, radioterapija, kortikosteroidi i loša zubna higijena također se smatraju faktorima rizika (vidjeti dio 4.4).
English: Clinical judgement of the treating physician should guide the management plan of each patient based on individual benefit/risk assessment.
Croatian: Liječnik koji provodi liječenje mora na temelju svoje kliničke procjene odrediti plan liječenja za svakog bolesnika pojedinačno na osnovi individualne procjene koristi i rizika.
English: Iasibon is indicated in adults for the prevention of skeletal events (pathological fractures, bone complications requiring radiotherapy or surgery) in patients with breast cancer and bone metastases.
Croatian: Iasibon je indiciran u odraslih za sprječavanje koštanih poremećaja (patološki prijelomi, komplikacije na kostima koje zahtijevaju radioterapiju ili operaciju) u bolesnika s rakom dojke i koštanim metastazama.
English: Prior to treatment with Iasibon the patient should be adequately rehydrated with 9 mg/ml (0.9%) sodium chloride.
Croatian: Prije liječenja lijekom Iasibon bolesnika treba odgovarajuće rehidrirati s 9 mg/ml (0,9%) otopine natrijevog klorida.
English: • Do not use this medicine after the expiry date which is stated on the folding box and on the label after EXP.
Croatian: • Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i naljepnici iza „Rok valjanosti“ ili kratice „EXP“.
English: How much to receive
Croatian: Koliko lijeka morate primiti
English: Therefore, Iasibon should not be used during pregnancy.
Croatian: Stoga se Iasibon ne smije koristiti u trudnoći.
English: For treatment of tumour induced hypercalcaemia, Iasibon concentrate for solution for infusion is generally given as a single infusion.
Croatian: Za liječenje hiperkalcijemije uzrokovane tumorom, Iasibon koncentrat za otopinu za infuziju obično se daje kao jednokratna infuzija.
English: Clinically relevant hypocalcaemia should be corrected by intravenous administration of calcium gluconate.
Croatian: Klinički značajnu hipokalcijemiju potrebno je korigirati intravenskom primjenom kalcijevog glukonata.
English: Do not take your tablet with any drink other than water
Croatian: Ne uzimajte tabletu ni s jednim drugim pićem osim vode.
English: • mouth ulcers, swollen lips (‘cheilitis'), oral thrush
Croatian: • vrijed usta, natečene usne (“heilitis”), oralna kandidijaza
English: Do not take a double dose to make up for a forgotten dose.
Croatian: Ako ste zaboravili uzeti Iasibon Nemojte uzeti dvostruku dozu da biste nadoknadili dozu koju ste propustili.
English: Exposure to ibandronic acid in patients with various degrees of renal impairment is related to creatinine clearance (CLcr).
Croatian: Izloženost ibandronatnoj kiselini u bolesnika s različitim stupnjevima oštećenja bubrega povezana je s klirensom kreatinina (CLcr).
English: Studies in lactating rats have demonstrated the presence of low levels of ibandronic acid in the milk following intravenous administration.
Croatian: Ispitivanja provedena na štakorima u laktacijskom razdoblju pokazala su niske razine ibandronatne kiseline u mlijeku nakon intravenske primjene.
English: Since Acetylsalicylic acid, Nonsteroidal Anti-Inflammatory medicinal products (NSAIDs) and bisphosphonates are associated with gastrointestinal irritation, caution should be taken during concomitant administration (see section 4.4).
Croatian: Budući da se acetilsalicilatna kiselina, nesteroidni protuupalni lijekovi i bisfosfonati povezuju s gastrointestinalnom iritacijom, potreban je oprez pri njihovoj istodobnoj primjeni (vidjeti dio 4.4).
English: Less frequently, decrease in serum calcium below normal range (hypocalcaemia) is reported.
Croatian: Manje često je prijavljeno sniženje razine kalcija u serumu ispod granice normale (hipokalcijemija).
English: Elderly (see section 4.2)
Croatian: Starije osobe (vidjeti dio 4.2)
English: Method of administration For intravenous administration.
Croatian: Za intravensku primjenu.
English: • a high level of alkaline phosphatase in your blood
Croatian: • visoka razina alkalne fosfataze u krvi
English: - Prevention of skeletal events (pathological fractures, bone complications requiring radiotherapy or surgery) in patients with breast cancer and bone metastases
Croatian: - prevencija koštanih događaja (patološki prijelomi, komplikacije na kostima koje zahtijevaju radioterapiju ili operaciju) u bolesnika s rakom dojke i koštanim metastazama.
English: During bisphosphonate treatment patients should be advised to report any thigh, hip or groin pain and any patient presenting with such symptoms should be evaluated for an incomplete femur fracture.
Croatian: Tijekom liječenja bisfosfonatima, bolesnike treba uputiti da prijave bol u bedrima, kukovima ili preponama te svakoga bolesnika s ovim simptomima treba pregledati ne bi li se otkrio nepotpuni lom bedrene kosti.
English: • heart and circulatory problems (including palpitations, heart attack, hypertension , high blood pressure and varicose veins)
Croatian: • problemi sa srcem i cirkulacijom (uključujući lupanje srca, srčani udar, povišeni krvni tlak
English: Posology The recommended dose is one 50 mg film-coated tablet daily.
Croatian: Doziranje Preporučena je doza jedna 50 mg filmom obložena tableta dnevno.
English: In clinical pharmacology trial WP18551, after a single dose intravenous administration of 6 mg (15 minutes infusion), mean AUC0-24 increased by 14% and 86%, respectively, in subjects with mild (mean estimated CLcr=68.1 mL/min) and moderate (mean estimated CLcr=41.2 mL/min) renal impairment compared to healthy volunteers (mean estimated CLcr=120 mL/min).
Croatian: nakon intravenske primjene jedne doze od 6 mg (15-minutna infuzija) prosječni AUC0-24 se povećao za 14% u ispitanika s blagim (srednja procijenjena vrijednost CLcr = 68,1 ml/min) odnosno za 86% u ispitanika s umjerenim (srednja procijenjena vrijednost CLcr = 41,2 ml/min) oštećenjem bubrega u usporedbi sa zdravim dobrovoljcima (srednja procijenjena vrijednost CLcr = 120 ml/min).
English: In the prevention of skeletal events in patients with breast cancer and bone metastases, treatment is most frequently associated with asthenia followed by rise in body temperature and headache.
Croatian: Kod sprječavanja koštanih događaja u bolesnika s rakom dojke i koštanim metastazama liječenje je najčešće povezano s astenijom praćenom povišenjem tjelesne temperature i glavoboljom.
English: Calcium containing solutions should not be mixed with Iasibon concentrate for solution for infusion.
Croatian: Otopine koje sadrže kalcij ne smiju se miješati s Iasibon koncentratom za otopinu za infuziju.
English: What Iasibon looks like and contents of the pack The film-coated tablets are white, round biconvex tablets supplied in Polyamide/Al/PVC - Aluminum foil blister.
Croatian: Filmom obložene tablete su bijele, okrugle, bikonveksne tablete pakirane u blistere od poliamid/Al/PVC - aluminijske folije.
English: PHARMACEUTICAL FORM AND CONTENTS Concentrate for solution for infusion 1 ampoule
Croatian: OBLIK I SADRŽAJ Koncentrat za otopinu za infuziju 1 ampula
English: The unabsorbed fraction of ibandronic acid is eliminated unchanged in the faeces.
Croatian: Neapsorbirana frakcija ibandronatne kiseline se nepromijenjena uklanja stolicom.
English: No difference was observed in the indicators of renal function.
Croatian: Nije opažena razlika u pokazateljima bubrežne funkcije.
English: ≥50 CLcr <80 6 mg (6 ml of concentrate for solution for infusion)
Croatian: ≥50 klirens kreatinina<80 6 mg (6 ml koncentrata za otopinu za infuziju)
English: Then you can have your first food and drink and and take any medicines or supplements
Croatian: Nakon toga možete uzeti svoj prvi jutarnji obrok, piće i druge lijekove ili nadomjesne pripravke.
English: Otherwise, some of the medicine could leak back into your food pipe/gullet (oesophagus)
Croatian: U suprotnom, dio lijeka vam se može vratiti u jednjak (ezofagus).
English: Patients with disturbances of bone and mineral metabolism Hypocalcaemia and other disturbances of bone and mineral metabolism should be effectively treated before starting Iasibon therapy.
Croatian: Bolesnici s poremećajima metabolizma kosti i minerala Hipokalcijemiju i ostale poremećaje metabolizma kostiju i minerala potrebno je učinkovito liječiti prije početka terapije lijekom Iasibon.
English: Uncommon Rare Very rare
Croatian: Rijetko Vrlo rijetko Nepoznato
English: The median time to relapse (return of albumin-corrected serum calcium above 3.0 mmol/l) was 18 to 26 days.
Croatian: Medijan vremena do recidiva (povratka razine kalcija u serumu korigiranog albuminom iznad 3,0 mmol/l) iznosio je 18 do 26 dana.
English: The pain reduction was consistently below baseline throughout the entire study and accompanied by a significantly reduced use of analgesics compared to placebo.
Croatian: Smanjenje boli bilo je tijekom cjelokupnog ispitivanja ispod početne vrijednosti i praćeno značajno smanjenom uporabom analgetika u usporedbi s placebom.
English: • if you have high or low levels of vitamin D, calcium or any other minerals
Croatian: • ako imate visoke ili niske razine vitamina D, kalcija ili drugih minerala • ako imate problema s bubrezima.
English: • flu-like symptoms, feeling generally unwell or in pain
Croatian: • simptomi slični gripi, opće loše osjećanje ili bol
English: Table 1 lists adverse drug reactions from the pivotal phase III studies (Treatment of tumour induced hypercalcaemia: 311 patients treated with ibandronic acid 2 mg or 4 mg; Prevention of skeletal events in patients with breast cancer and bone metastases: 152 patients treated with ibandronic acid 6 mg), and from post-marketing experience.
Croatian: Tablici 1 popisane su nuspojave iz pivotalnih ispitivanja faze III (Liječenje hiperkalcijemije uzrokovane tumorom: 311 bolesnika liječenih ibandronatnom kiselinom u dozi od 2 mg ili 4 mg; Prevencija koštanih događaja u bolesnika s rakom dojke i koštanim metastazama: 152 bolesnika liječena ibandronatnom kiselinom u dozi od 6 mg) i iz iskustva nakon stavljanja lijeka na tržište.
English: • The active substance is ibandronic acid.
Croatian: • Djelatna tvar je ibandronatna kiselina.
English: The deterioration in Quality of Life was significantly less in Ibandronate treated patients compared with placebo.
Croatian: Pogoršanje kvalitete života bilo je znatno manje u bolesnika liječenih ibandronatom u usporedbi s placebom.
English: Albumin-corrected Serum calcium (mmol/l)
Croatian: kalcij u serumu korigiran albuminom (mmol/l)
English: On the basis of the pharmacodynamic and pharmacokinetic profile and reported adverse reactions, it is expected that Iasibon has no or negligible influence on the ability to drive and use machines.
Croatian: S obzirom na farmakodinamički i farmakokinetički profil lijeka i prijavljene nuspojave, očekuje se da Iasibon ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Osteonecrosis of the jaw is generally associated with tooth extraction and/or local infection (including osteomyelitis).
Croatian: Osteonekroza čeljusti obično je povezana s vađenjem zuba i/ili lokalnom infekcijom (uključujući osteomijelitis).
English: Receiving this medicine
Croatian: Primanje lijeka
English: Do not receive Iasibon
Croatian: Nemojte primati Iasibon
English: Protein binding in human plasma is approximately 87% at therapeutic concentrations, and thus interaction with other medicinal products, due to displacement is unlikely.
Croatian: Vezanje za proteine plazme u ljudi iznosi otprilike 87% pri terapijskim koncentracijama i stoga interakcija lijeka s drugim lijekovima zbog istiskivanja nije vjerojatna.
English: ≥30 CLcr <50 4 mg (4 ml of concentrate for solution for infusion)
Croatian: ≥30 klirens kreatinina <50 4 mg (4 ml koncentrata za otopinu za infuziju)
English: - Treatment of tumour-induced hypercalcaemia with or without metastases
Croatian: - liječenje hiperkalcijemije nastale kao posljedica tumora s metastazama ili bez njih.
English: - Hypersensitivity to ibandronic acid or to any of the excipients listed in section 6.1.
Croatian: - Preosjetljivost na ibandronatnu kiselinu ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2).
Croatian: Lijek se izdaje na ograničeni recept (Vidjeti Dodatak I: Sažetak opisa svojstava lijeka, dio 4.2).
English: The inhibition of endogenous bone resorption has also been documented by 45Ca kinetic studies and by the release of radioactive tetracycline previously incorporated into the skeleton.
Croatian: Inhibicija endogene resorpcije kosti dokazana je i u kinetičkim ispitivanjima s 45Ca te otpuštanjem radioaktivnog tetraciklina prethodno ugrađenog u skelet.
English: For the prevention of skeletal events in patients with breast cancer and bone metastases, the Iasibon infusion is repeated at 3-4 week intervals.
Croatian: Za prevenciju koštanih događaja u bolesnika s rakom dojke i koštanim metastazama, infuzija lijeka Iasibon ponavlja se u intervalima od 3 - 4 tjedna.