FrancophonIA/ELRC3.0 huggingface dataset:
English: Paradoxical bronchopasm responds to a rapid-acting inhaled bronchodilator and should be treated straightaway (see section 4.8).
Slovenian: Paradoksni bronhospazem se odziva na hitrodelujoči inhalacijski bronhodilatator in ga moramo zdraviti takoj (glejte poglavje 4.8).
English: If this is not possible the time interval between administration of the inhibitor and budesonide should be as long as possible (see section 4.4).
Slovenian: Če to ni mogoče, pazite, da bo časovni razmik med uporabo zaviralca in budezonida kolikor je mogoče dolg (glejte poglavje 4.4).
English: • Medicines for allergies or antihistamines (such as terfenadine).
Slovenian: • zdravila proti alergijam ali antihistaminiki, (kot je npr. Terfenadin).
English: Take care not to block the air vents.
Slovenian: Pazite, da ne zamašite oddušnikov.
English: Additional blood glucose controls should be considered in diabetic patients.
Slovenian: Pri bolnikih s sladkorno boleznijo je treba razmisliti o dodatnih kontrolnih meritvah glukoze v krvi.
English: • Sudden acute wheezing and/or shortness of breath immediately after using your inhaler (also referred to as ‘paradoxical bronchospasm'.
Slovenian: • nenadno akutno piskajoče in/ali težko dihanje nemudoma po uporabi inhalatorja (imenovano tudi »paradoksni bronhospazem«).
English: It is also important to advise patients not to shake the inhaler before use and not to breathe out through the Spiromax and not to block the air vents when they are preparing the “Breathe” step.
Slovenian: Pomembno je tudi, da bolnikom svetujete, naj inhalatorja pred uporabo ne stresajo, naj ne izdihnejo skozi inhalator Spiromax in naj ne zamašijo oddušnikov med pripravo koraka »Vdihnite«.
English: The exact mechanism responsible for the antiinflammatory effect of glucocorticosteroids is unknown.
Slovenian: Natančen mehanizem protivnetnega delovanja kortikosteroidov ni znan.
English: Contents of the pack and other information (page 19)
Slovenian: (stran 19) Vsebina pakiranja in dodatne informacije (stran 19)
English: Your doctor may need to change your treatment in order to reduce your symptoms of asthma (breathlessness, wheezing and cough) and improve your asthma control and make your breathing easier.
Slovenian: Zdravnik bo morda moral spremeniti vaše zdravljenje, da bi zmanjšal vaše simptome astme (zasoplost, piskanje v pljučih in kašelj) in izboljšal kontolo vaše astme ter olajšal vaše dihanje.
English: β2 adrenoreceptor agonists
Slovenian: Agonisti adrenergičnih receptorjev β2
English: If growth is slowed, therapy should be re-evaluated with the aim of reducing the dose of inhaled corticosteroid to the lowest dose at which effective control of asthma is maintained, if possible.
Slovenian: V primeru upočasnitve rasti je treba ponovno ovrednotiti zdravljenje z namenom zmanjšanja odmerka inhalacijskih kortikosteroidov na najmanjši odmerek, pri katerem je ohranjen učinkovit nadzor nad simptomi astme, če je to mogoče.
English: • Keep the mouthpiece closed all the time unless you are about to use your inhaler.
Slovenian: • Ustnik mora biti ves čas zaprt, razen kadar nameravate uporabiti inhalator.
English: Animal reproduction studies with formoterol have shown a somewhat reduced fertility in male rats at high systemic exposure and implantation losses as well as decreased early postnatal survival and birth weight at considerably higher systemic exposures than those reached during clinical use.
Slovenian: Študije razmnoževanja živali z uporabo formoterola so pokazale nekoliko zmanjšano plodnost podganjih samcev pri veliki sistemski izpostavljenosti ter izgube implantatov, pa tudi zmanjšano zgodnje postnatalno preživetje in manjšo maso mladičev ob kotitvi pri stopnjah sistemske izpostavljenosti, ki so bile znatno višje od tiste, dosežene ob klinični uporabi zdravila.
English: If you are regularly using up to 8 inhalations a day or you need to increase the amount of ‘reliever inhaler' you require, you should see your doctor as soon as possible.
Slovenian: Če redno uporabljate do 8 inhalacij na dan ali morate povečati odmerek »inhalatorja z olajševalcem«, ki ga potrebujete, obiščite zdravnika.
English: However, these animal experimental results do not seem to be relevant in humans.
Slovenian: Kaže pa, da ti eksperimentalni podatki, dobljeni na živalih, ne veljajo tudi za človeka.
English: • Do not shake your inhaler before use.
Slovenian: • Inhalatorja pred uporabo ne stresajte.
English: Close: Breathe out gently and close the mouthpiece cover.
Slovenian: Zaprite: Rahlo izdihnite in zaprite pokrovček ustnika.
English: Place the mouthpiece between your teeth.
Slovenian: Ustnik nežno namestite med zobe.
English: Plasma protein binding is approximately 50% for formoterol and 90% for budesonide.
Slovenian: Vezava formoterola na plazemske beljakovine je približno 50 %, vezava budezonida pa 90 %.
English: After inhalation, 8% to 13% of the delivered dose of formoterol is excreted unmetabolised in the urine.
Slovenian: Po inhalaciji se 8 % do 13 % prejetega odmerka formoterola izloči s sečem v nespremenjeni obliki.
English: The toxicity observed in animal studies with budesonide and formoterol, given in combination or separately, were effects associated with exaggerated pharmacological activity.
Slovenian: Toksični učinki, ki so jih ugotavljali v študijah uporabe budezonida in formoterola (danih v kombinaciji ali ločeno) pri živalih, so bili vezani na pretirano farmakološko aktivnost zdravila.
English: Inhaled budesonide has less severe adverse reactions than systemic corticosteroids.
Slovenian: Inhalirani budezonid ima manj hudih neželenih učinkov kot sistemski kortikosteroidi.
English: Formoterol is a selective β2 adrenoceptor agonist that when inhaled results in rapid and long-acting relaxation of bronchial smooth muscle in patients with reversible airways obstruction.
Slovenian: Formoterol je selektiven agonist adrenergičnih receptorjev β2 , ki povzroči hitro in dolgodelujočo relaksacijo gladkega mišičja bronhijev pri bolnikih z reverzibilno obstrukcijo dihalnih poti.
English: In both studies, lung function was improved and the treatment was well tolerated compared to the corresponding dose of budesonide alone.
Slovenian: Pljučna funkcija se je izboljšala v obeh študijah, bolniki pa so dobro prenašali zdravljenje, v primerjavi z odgovarjajočim odmerkom budezonida v monoterapiji.
English: Rinse your mouth with water after every dose, and spit it out.
Slovenian: Po vsakem odmerku si usta splaknite z vodo in jo izpljunite.
English: Very few patients had PIFRs below 40L/min; when PIFRs were less than 40L/min there appeared to be no clustering by age or disease severity.
Slovenian: Pri zelo malo bolnikih je bila najvišja stopnja PIFR nižja od 40 l/min; v teh primerih ni kazalo, da bi bilo to povezano s starostjo ali resnostjo bolezni.
English: The specific properties of budesonide and formoterol allow the combination to be used as maintenance treatment of asthma.
Slovenian: Posebne lastnosti budezonida in formoterola omogočajo, da se kombinacija teh dveh učinkovin uporablja za vzdrževalno zdravljenje astme.
English: In usual practice when control of symptoms is achieved with the twice daily dose regimen with a lower strength product, titration to a lower effective dose could include once daily dosing when, in the opinion of the prescriber, a long-acting bronchodilator is required to maintain control rather than treatment with an inhaled corticosteroid alone.
Slovenian: Ko v običajni praksi dosežemo ustrezen nadzor simptomov z odmerjanjem nižje jakosti zdravila dvakrat na dan, lahko titracijo do manjšega še učinkovitega odmerka opravimo tudi z zmanjšanjem pogostnosti odmerjanja na enkrat na dan, če je po mnenju zdravnika predpisovalca za nadzor bolezni potreben dolgodelujoči bronhodilatator in ne zdravljenje samo z inhalacijskim kortikosteroidom.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/14/950/001
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/14/950/001
English: • Medicines for Parkinson's disease (such as levodopa).
Slovenian: • zdravila proti Parkinsonovi bolezni (npr. levodopa).
English: When to start using a new Spiromax
Slovenian: Kdaj začeti uporabljati nov inhalator Spiromax
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT Contains 1 inhaler.
Slovenian: VSEBINA, IZRAŽENA Z MASO, PROSTORNINO ALI ŠTEVILOM ENOT Vsebuje 1 inhalator.
English: It is not known whether formoterol passes into human breast milk.
Slovenian: Ni znano, ali se formoterol izloča v materino mleko.
English: Budesonide is excreted in breast milk.
Slovenian: Budezonid se izloča v materino mleko.
English: How to take an inhalation Every time you need to take an inhalation, follow the instructions below.
Slovenian: Vsakokrat, ko morate vdihniti zdravilo, upoštevajte spodnja navodila.
English: Data on approximately 2000 exposed pregnancies indicate no increased teratogenic risk associated with the use of inhaled budesonide.
Slovenian: Podatki, zbrani pri približno 2000 nosečnicah, ki so bile izpostavljene inhalacijskemu budezonidu, niso pokazali povečanega tveganja za pojav teratogenih učinkov pri uporabi inhalacijskega budezonida.
English: A fixed-dose combination therapy of budesonide and formoterol fumarate dihydrate should therefore not be given together with β adrenergic blockers (including eye drops) unless there are compelling reasons.
Slovenian: Zdravljenja s kombinacijo budezonida in formoterolijevega fumarata dihidrata v fiksnih odmerkih torej ne bi smeli predpisovati skupaj z antagonisti adrenergičnih receptorjev β (vključno s kapljicami za oko), če za to ni tehtnih razlogov.
English: The exposure of budesonide and formoterol may be increased in patients with liver disease.
Slovenian: Izpostavljenost budezonidu in formoterolu je lahko povečana pri bolnikih z jetrnimi boleznimi.
English: Each dose contains approximately 5 milligrams of lactose (as monohydrate).
Slovenian: En odmerek vsebuje približno 5 miligramov laktoze (v obliki monohidrata).
English: • Tricyclic antidepressants (such as amitriptyline) and the antidepressant nefazodone.
Slovenian: • triciklične antidepresive (npr. amitriptilin) in antidepresiv nefazodon.
English: Only negligible amounts of unchanged budesonide have been detected in the urine.
Slovenian: V seču so našli le zanemarljive količine nespremenjenega budezonida.
English: Sudden and progressive deterioration in control of asthma is potentially life-threatening and the patient should undergo urgent medical assessment.
Slovenian: Nenadno in progresivno poslabšanje nadzora simptomov astme je lahko za bolnika življenjsko nevarno, zato je potreben nujen zdravniški pregled.
English: • Bronchospasm (tightening of the muscles in the airways which causes wheezing and shortness of breath).
Slovenian: • bronhospazem (krči mišic dihalnih poti, ki povzročijo piskajoče in kratka sapa).
English: High dose corticosteroids
Slovenian: Kortikosteroidi v visokih odmerkih
English: However, these animal experimental results do not seem to be relevant in humans at the recommended doses.
Slovenian: Vendar pa kaže, da ti eksperimentalni podatki, dobljeni na živalih, ne veljajo tudi za uporabo zdravila pri človeku v priporočenih odmerkih.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/14/950/002
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/14/950/002
English: The dose should be titrated to the lowest dose at which effective control of symptoms is maintained.
Slovenian: Odmerek je treba titrirati do najmanjšega odmerka, pri katerem je še ohranjen učinkovit nadzor nad simptomi.
English: It works by relaxing the muscles in your airways.
Slovenian: Deluje tako, da sprošča mišice v dihalih.
English: Always keep your ‘reliever inhaler' with you and use it to relieve sudden attacks of breathlessness and wheezing.
Slovenian: »Inhalator z olajševalcem« imejte vedno pri sebi in ga uporabite za lajšanje napadov zasoplosti ali piskajočega dihanja.
English: Limited data about this interaction for high-dose inhaled budesonide indicates that marked increases in plasma levels (on average four fold) may occur if itraconazole, 200 mg once daily, is administered concomitantly with inhaled budesonide (single dose of 1000 micrograms).
Slovenian: Omejeni podatki o tej interakciji za visokoodmerni inhalacijski budezonid kažejo, da lahko pride do bistvenega povečanja plazemskih koncentracij (v povprečju štirikratnih), če itrakonazol, 200 mg enkrat na dan, dajemo sočasno z inhalacijskim budezonidom (enkratni odmerek
English: The potent CYP3A4 inhibitor ketoconazole, 200 mg once daily, increased plasma levels of concomitantly orally administered budesonide (single dose 3 mg) on average six-fold.
Slovenian: Močni zaviralec CYP3A4 ketokonazol je v odmerku 200 mg enkrat na dan povečal plazemske koncentracije sočasno uporabljanega peroralnega budezonida (enkratni odmerek 3 mg) v povprečju za 6-krat.
English: If this is not possible the time interval between administrations of the interacting medicinal products should be as long as possible.
Slovenian: Če to ni mogoče, pazite, da bo časovni razmik med njuno uporabo kolikor je mogoče dolg.
English: Concomitant treatment with quinidine, disopyramide, procainamide, phenothiazines, antihistamines (terfenadine), monoamine oxidase inhibitors and tricyclic antidepressants can prolong the QTc-interval and increase the risk of ventricular arrhythmias.
Slovenian: Sočasno zdravljenje s kinidinom, dizopiramidom, prokainamidom, fenotiazini, antihistaminiki (terfenadin), zaviralci monoaminooksidaze in tricikličnimi antidepresivi lahko podaljša interval QTc in poveča nevarnost za pojav ventrikularnih aritmij.
English: 1 inhaler containing 120 doses.
Slovenian: 1 inhalator, ki vsebuje 120 odmerkov.
English: Pharmacodynamic interactions β adrenergic blockers can weaken or inhibit the effect of formoterol.
Slovenian: Farmakodinamične interakcije Adrenergični zaviralci receptorjev β lahko oslabijo ali zavrejo delovanje formoterola.
English: Depression, behavioural changes (predominantly in children)
Slovenian: anksioznost, motnje spanja zelo redki depresija, vedenjske spremembe (pretežno pri otrocih)
English: Remove the Spiromax from mouth and hold the breath for 10 seconds or as long as comfortable for the patients.
Slovenian: Odstranite inhalator Spiromax iz ust in zadržite dih za 10 sekund ali za toliko časa, kot ga lahko, ne da bi vam bilo ob tem neudobno.
English: The mean PIFR achieved by patients with asthma was over 60L/min, a flow rate at which both devices studied are known to deliver comparable amounts of drug to the lungs.
Slovenian: Povprečna PIFR, ki so jo dosegli bolniki z astmo, je presegala 60 l/min, pri tej stopnji obe preiskovani napravi v pljuča dovedeta primerljivi količini zdravila.
English: • Do not use this medicine after the expiry date which is stated on the carton or on the label of your inhaler after EXP.
Slovenian: • Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli ali nalepki inhalatorja poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Treatment with β2 adrenoceptor agonists may result in an increase in blood levels of insulin, free fatty acids, glycerol and ketone bodies.
Slovenian: Zdravljenje z agonisti adrenergičnih receptorjev β2 lahko povzroči povečanje koncentracije insulina, prostih maščobnih kislin, glicerola in ketonskih teles v krvi.
English: Oropharyngeal Candida infection usually responds to topical anti-fungal treatment without the need to discontinue the inhaled corticosteroid.
Slovenian: Orofaringealna okužba s kandido se običajno odziva na lokalno antimikotično zdravljenje, ne da bi bilo treba prekiniti jemanje inhalacijskega kortikosteroida.
English: If these effects occur, they are usually mild and usually disappear as you continue to use Budesonide/Formoterol Teva Pharma B.V.
Slovenian: Če se ti učinki pojavijo, so po navadi blagi in po navadi izginejo med nadaljevanjem zdravljenja z zdravilom Budezonid/formoterol Teva Pharma B.V..
English: • Uneven heartbeat.
Slovenian: • neenakomerno bitje srca.
English: Long-term studies with inhaled budesonide in children at mean daily doses of 400 micrograms (metered dose) or in adults at daily doses of 800 micrograms (metered dose) have not shown any significant effects on bone mineral density.
Slovenian: 400 mikrogramov (odmerjen odmerek) ali pri odraslih v dnevnih odmerkih 800 mikrogramov (odmerjen odmerek) niso pokazale pomembnega vpliva na kostno mineralno gostoto.
English: Use your separate ‘reliever inhaler' to treat asthma symptoms when they happen.
Slovenian: Svoj drugi »inhalator z olajševalcem« uporabljajte za odpravljanje simptomov astme, ko se pojavijo.
English: Other possible side effects:
Slovenian: Drugi možni neželeni učinki:
English: In patients using potent CYP3A4 inhibitors, a budesonide/formoterol fumarate fixed-dose combination is not recommended.
Slovenian: Pri bolnikih, ki jemljejo močne zaviralce CYP3A4, zdravljenje s fiksno kombinacijo budezonida/formoterolijevega fumarata ni priporočeno.
English: • Swelling of your face, particularly around your mouth (tongue and/or throat and/or difficulty to swallow) or hives together with difficulties to breathe (angioedema) and/or sudden feeling of faintness.
Slovenian: • otekanje obraza, zlasti okrog ust (jezik in/ali žrelo in/ali težave s požiranjem) ali koprivnica,
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze, ne smejo jemati tega zdravila.
English: • Medicines to treat infections (such as ketoconazole, itraconazole, voriconazole, posaconazole,
Slovenian: • zdravila za zdravljenje okužb (npr. ketokonazol, itrakonazol, vorikonazol, posakonazol,
English: Budesonide is eliminated via metabolism mainly catalysed by the enzyme CYP3A4.
Slovenian: Budezonid se izloča s presnovo, predvsem s pomočjo encima CYP3A4.
English: Variations in blood pressure
Slovenian: Žilne bolezni spremembe krvnega tlaka
English: Special populations:
Slovenian: Posebne skupine bolnikov:
English: • Write the date you opened the foil pouch on the label of the inhaler.
Slovenian: • Zabeležite datum odprtja vrečke iz folije na nalepki inhalatorja.
English: Not for use in children or adolescents under 18 years of age.
Slovenian: Ni za uporabo pri otrocih ali mladostnikih, mlajših od 18 let.
English: In animal studies glucocorticosteroids have been shown to induce malformations (see section 5.3).
Slovenian: V študijah na živalih so dokazali, da kortikosteroidi povzročajo deformacije ploda (glejte poglavje 5.3).
English: Concomitant use of other β adrenergic medicinal products and anticholinergic medicinal products can have a potentially additive bronchodilating effect.
Slovenian: Pri sočasni uporabi drugih agonistov adrenergičnih receptorjev β in antiholinergičnih zdravil lahko pride do morebitnega aditivnega bronhodilatatornega učinka.
English: An overdose of formoterol would likely lead to effects that are typical for β2 adrenoceptor agonists: tremor, headache, palpitations.
Slovenian: Preveliko odmerjanje formoterola bi najverjetneje povzročilo učinke, ki so tudi sicer značilni za agoniste adrenergičnih receptorjev β2: tremor, glavobol, palpitacije.
English: Effects on bone density
Slovenian: Učinki na kostno gostoto
English: Inhalation use.
Slovenian: Način uporabe za inhaliranje
English: However, do not take a double dose to make up for a forgotten dose.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: • you have a lung infection.
Slovenian: • če imate okužbo pljuč.
English: Paradoxical bronchopasm responds to a rapidacting inhaled bronchodilator and should be treated straightaway.
Slovenian: Paradoksni bronhospazem se odziva na hitrodelujoči inhalacijski bronhodilatator in ga moramo zdraviti takoj.
English: There are no indications of any metabolic interactions or any displacement reactions between formoterol and budesonide.
Slovenian: Ni znakov za obstoj kakršnih koli presnovnih interakcij ali reakcij izrivanja med formoterolom in budezonidom.
English: Budesonide undergoes an extensive degree (approximately 90%) of biotransformation on first passage through the liver to metabolites of low glucocorticosteroid activity.
Slovenian: Budezonid se v veliki meri (približno 90 %) presnovi že pri prvem prehodu skozi jetra do presnovkov z majhno kortikosteroidno aktivnostjo.
English: Acute overdose with budesonide, even in excessive doses, is not expected to be a clinical problem.
Slovenian: Pri akutnem prevelikem odmerjanju budezonida, tudi v izrazito prevelikih odmerkih, ne pričakujemo kliničnih problemov.
English: Inhaled formoterol is rapidly absorbed and the maximum plasma concentration is reached within 10 minutes after inhalation.
Slovenian: Inhalirani formoterol se hitro absorbira in doseže največjo plazemsko koncentracijo 10 minut po inhalaciji.
English: However, do not adjust the number of inhalations your doctor has prescribed without talking to your doctor first.
Slovenian: Števila predpisanih inhalacij ne prilagajajte sami, ne da bi se prej posvetovali z zdravnikom.
English: Side panel: For use in adults 18 years of age and older only.
Slovenian: Stranska ploskev: Samo za uporabo pri odraslih, starih 18 in več let.
English: This is not likely to be relevant for humans given recommended doses.
Slovenian: Ta izsledek verjetno ni relevanten za ljudi, ki jemljejo priporočene odmerke zdravila.
English: Open: Hold the Spiromax with the mouthpiece cover at the bottom and open the mouthpiece cover by folding it down until it is fully opened when one click is heard.
Slovenian: Odprite: Držite inhalator Spiromax pokonci, tako da je ustnik spodaj, in odprite pokrovček ustnika tako, da ga preganete navzdol, dokler ni v celoti odprt in ne zaslišite klika.
English: If oropharyngeal thrush occurs, patients should also rinse their mouth with water after the as-needed inhalations.
Slovenian: Ob pojavu orofaringealne kandidoze si morajo bolniki sprati usta tudi po vsaki inhalaciji po potrebi.
English: Clinical studies in adults have shown that the addition of formoterol to budesonide improved asthma symptoms and lung function, and reduced exacerbations.
Slovenian: Klinične študije pri odraslih so pokazale, da se z dodatkom formoterola k budezonidu ublažijo simptomi astme, izboljša se pljučna funkcija, pogostnost napadov pa zmanjša.
English: Caution should be observed when treating patients with prolongation of the QTc-interval.
Slovenian: Pri zdravljenju bolnikov s podaljšanim intervalom Q-Tc je potrebna previdnost.
English: During transfer from oral therapy to a budesonide/formoterol fumarate fixed-dose combination therapy, a generally lower systemic steroid action will be experienced which may result in the appearance of allergic or arthritic symptoms such as rhinitis, eczema and muscle and joint pain.
Slovenian: Med prehodom s peroralnega zdravljenja na zdravljenje s fiksno kombinacijo budezonida/formoterolijevega fumarata se običajno pojavi splošno manjše delovanje sistemskih steroidov, kar lahko povzroči pojav alergijskih ali artritičnih simptomov, kot so npr. rinitis, ekcem in bolečine v mišicah in sklepih.
English: In studies, mean lung deposition of budesonide after inhalation via the powder inhaler ranged from 32% to 44% of the delivered dose.
Slovenian: V študijah se je povprečna vrednost količine budezonida, odložene v pljučih ob uporabi inhalatorja, gibala med 32 % in 44 % dovedenega odmerka.
English: Budesonide and formoterol have not been observed to interact with any other medicinal products used in the treatment of asthma.
Slovenian: Medsebojnega delovanja budezonida in formoterola z drugimi zdravili za zdravljenje astme niso opazili.
English: For budesonide, AUC was slightly higher, rate of absorption more rapid and maximal plasma concentration higher after administration of the fixed combination.
Slovenian: Površina pod krivuljo plazemske koncentracije po času (AUC) je bila pri budezonidu nekoliko večja, absorpcija hitrejša, največja plazemska koncentracija pa višja po dajanju fiksne kombinacije.