FrancophonIA/ELRC3.0 huggingface dataset:
English: 18 mg/kg (0.36 ml/kg ); maximum 700 mg or 14 ml
Slovenian: 18 mg/kg (0,36 ml/kg); največ 700 mg ali 14 ml Peroralno suspenzijo je treba vzeti s hrano
English: Telzir suspension is administered orally.
Slovenian: Zdravilo Telzir suspenzija se uporablja peroralno.
English: What Telzir looks like and contents of the pack Telzir is supplied in plastic bottles containing 60 film-coated tablets.
Slovenian: Zdravilo Telzir je na voljo v plastenkah, ki vsebujejo 60 filmsko obloženih tablet.
English: Telzir with ritonavir must not be co-administered with medicinal products with narrow therapeutic windows that are highly dependent on CYP2D6 metabolism, e.g. flecainide and propafenone (see section 4.5).
Slovenian: Zdravilo Telzir v kombinaciji z ritonavirjem se ne sme uporabljati sočasno z zdravili ozke terapevtske širine, ki so pri svoji presnovi zelo odvisni od CYP2D6, npr. s flekainidom in propafenonom (glejte poglavje 4.5).
English: In a clinical study on pharmacokinetics of fosamprenavir in paediatric patients, eight subjects 12 to 18 years of age received the standard fosamprenavir adult tablet dose of 700 mg twice daily (with ritonavir 100 mg twice daily).
Slovenian: V klinični študiji o farmakokinetiki fosamprenavirja pri pediatričnih bolnikih, je 8 oseb, starih od 12 do 18 let prejemalo standardni odmerek fosamprenavirja za odrasle v obliki 700 mg tablet dvakrat na dan (z ritonavirjem 100 mg dvakrat na dan).
English: Administration of fosamprenavir 700 mg twice daily with ritonavir 100 mg twice daily results in plasma amprenavir concentrations (data from study APV30003 in antiretroviral experienced patients) which results in protein adjusted median ratios of Cmin/IC50 and Cmin/IC95 of 21.7 (range 1.19-240) and 3.21 (range 0.26-30.0), respectively.
Slovenian: Pri uporabi fosamprenavirja v odmerku 700 mg dvakrat na dan skupaj z ritonavirjem v odmerku 100 mg dvakrat na dan se pojavijo plazemske koncentracije amprenavirja (podatki iz študije APV30003 pri bolnikih, ki so že bili zdravljeni s protiretrovirusnimi zdravili), katerih na proteine prilagojena vrednost srednjega razmerja Cmin/IC50 znaša 21,7 (razpon 1,19-240), na proteine prilagojena vrednost srednjega razmerja Cmin/IC95 pa 3,21 (razpon 0,26-30,0).
English: In moderately antiretroviral experienced adults, Telzir in combination with low dose ritonavir has not been shown to be as effective as lopinavir / ritonavir.
Slovenian: Pri odraslih bolnikih, ki so bili predhodno zmerno zdravljeni s protiretrovirusnimi zdravili, ni bilo dokazano, da bi bilo zdravilo Telzir v kombinaciji z nizkim odmerkom ritonavirja tako učinkovito kot kombinacija lopinavir/ritonavir.
English: Results were in favour of the lopinavir / ritonavir arm as detailed below.
Slovenian: Rezultati so bili v korist skupine lopinavir/ritonavir, kot je prikazano v nadaljevanju.
English: The adverse reaction profile was similar across all the respective adult studies: antiretroviral naïve patients (APV30002, ESS100732), protease inhibitor experienced (twice daily dosing, APV30003) patients.
Slovenian: Profil neželenih učinkov je bil pri odraslih podoben v vseh študijah: tako pri populaciji odraslih bolnikov, ki s protiretrovirusnimi zdravili še ni bila zdravljena (APV30002, ESS100732), kot pri populaciji, ki je že bila zdravljena z zaviralcem proteaz (odmerjanje dvakrat dnevno, APV30003).
English: Table 3 Efficacy at Week 48 Outcomes in APV30003 ITT(E) Population (ART-experienced Patients)
Slovenian: Preglednica 3: Rezultati učinkovitost v 48. tednu pri študiji APV30003 ITT(E) populacija (bolniki, ki so se predhodno že zdravili z zaviralci proteaz)
English: Clarithromycin
Slovenian: klaritromicin
English: Change from baseline in CD4 cells (cells/µl)
Slovenian: Sprememba od izhodiščne vrednosti v številu CD4 celic (cells/l)
English: • if they have been taking combination therapy for a long time
Slovenian: • ki se dolgotrajno zdravijo s kombiniranim zdravljenjem.
English: Amprenavir: AUC12 ↓ 0.65 Amprenavir: Cmax ↓ 0.66
Slovenian: amprenavir: AUC12  0,65 amprenavir: Cmax  0,66 amprenavir: C12  0,64
English: Table 2 Efficacy Outcome at Weeks 96 and 144 in ESS100732 Extension (ART-Naïve Patients)
Slovenian: Preglednica 2: Rezultati učinkovitosti v 96. in 144. tednu pri razširjeni študiji ESS100732 (bolniki, ki predhodno še niso bili zdravljeni s protiretrovirusnimi zdravili)
English: When warfarin or other oral anticoagulants are coadministered with Telzir a reinforced monitoring of INR (International Normalised Ratio) is recommended (see section 4.5).
Slovenian: Če se varfarin ali drugi peroralni antitrombotiki dajejo sočasno z zdravilom Telzir, je priporočljivo poostreno nadzirati INR (internacionalno normalizirano razmerje) (glejte poglavje 4.5).
English: Amprenavir AUC ↑↑ 69% Amprenavir Cmin ↑ 77% Amprenavir Cmax ↑ 62%
Slovenian: amprenavir AUC  69% amprenavir Cmin 77% amprenavir Cmax 62% etravirin AUC ↔
English: The use of Telzir concomitantly with halofantrine or lidocaine (systemic) is not recommended (see section 4.5).
Slovenian: Zdravila Telzir ni priporočljivo uporabljati sočasno s halofantrinom ali z lidokainom (sistemskim) (glejte poglavje 4.5).
English: Compared to the historical adult population receiving fosamprenavir / ritonavir 700 / 100 mg twice daily, 12 to 18 year old subjects had 20 % lower plasma APV AUC(024), 23 % lower Cmax, and 20 % lower Cmin values.
Slovenian: V primerjavi s prejšnjo odraslo populacijo, ki je prejemala fosamprenavir/ritonavir 700/100 mg dvakrat na dan, so imeli od 12 do 18 let stari bolniki za 20 % nižje plazemske koncentracije APV (AUC(0-24)), za 23 % nižjo Cmax in 20 % nižje Cmin vrednosti.
English: What Telzir contains
Slovenian: Kaj vsebuje zdravilo Telzir
English: Therefore medicinal products that are inducers, inhibitors or substrates of CYP3A4 must be used with caution when administered concurrently with Telzir with ritonavir (see sections 4.3 and 4.5).
Slovenian: Pri sočasni uporabi zdravil, ki so induktorji, zaviralci ali substrati CYP3A4, in zdravila Telzir v kombinaciji z ritonavirjem je torej potrebna previdnost (glejte poglavji 4.3 in 4.5).
English: Telzir/ritonavir should not be co-administered with orally administered midazolam (see section 4.3), whereas caution should be used with co-administration of Telzir/ritonavir and parenteral midazolam.
Slovenian: Zdravilo Telzir naj se ne daje sočasno s peroralno apliciranim midazolamom (glejte poglavje 4.3), ob sočasni parenteralni aplikaciji zdravila Telzir/ritonavir in midazolama pa je potrebna previdnost.
English: In rats only there was an increase in interstitial cell hyperplasia in males at exposure levels equivalent to 0.5-fold those in humans, and an increase in uterine endometrial adenocarcinoma in females at an exposure level equivalent to 1.1-fold those in humans.
Slovenian: Le pri podganah so pri samcih pri izpostavljenosti, ki je ustrezala 0,5-kratni izpostavljenosti pri človeku, ugotovili večjo pojavnost hiperplazije intersticijskih celic, pri samicah pa pri izpostavljenosti, ki je ustrezala 1,1-kratni izpostavljenosti pri človeku, večjo pojavnost adenokarcinomov na maternični sluznici.
English: Amprenavir metabolism is inhibited by ritonavir, via inhibition of CYP3A4, resulting in increased plasma concentrations of amprenavir.
Slovenian: Z inhibicijo CYP3A4 ritonavir zavira presnovo amprenavirja, kar vodi do večjih plazemskih koncentracij amprenavirja.
English: Patients should be warned about these possible side effects when using PDE5 inhibitors with Telzir/ritonavir (see section 4.4).
Slovenian: Bolnike je treba v primeru uporabe inhibitorjev PDE5 z zdravilom Telzir/ritonavir opozoriti na možne neželene učinke (glejte poglavje 4.4).
English: (R-) methadone: AUC ↓
Slovenian: (R-) metadon: AUC  18%
English: Note that co-administration of Telzir with low dose ritonavir with sildenafil used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Slovenian: Upoštevajte, da je sočasna uporaba zdravila Telzir z majhnimi odmerki ritonavirja hkrati s sildenafilom, ki se uporablja za zdravljenje pljučne arterijske hipertenzije, kontraindicirana (glejte poglavje 4.3).
English: The Telzir oral suspension contains propyl and methyl parahydroxybenzoate.
Slovenian: Zdravilo Telzir peroralna suspenzija vsebuje propilparahidroksibenzoat in metilparahidroksibenzoat.
English: (CYP2D6 inhibition by RTV)
Slovenian: (inhibicija CYP2D6 z RTV)
English: Rhabdomyolysis: an increase in CPK, myalgia, myositis, and rarely, rhabdomyolysis, have been reported with protease inhibitors, more specifically in association with nucleoside analogues.
Slovenian: Rabdomioliza: V povezavi z zaviralci proteaz, natančneje v povezavi z nukleozidnimi analogi, so poročali o zvišanih vrednostih CPK, mialgiji, miozitisu in redkeje o rabdomiolizi.
English: Administration of the fosamprenavir oral suspension formulation with a high fat meal (967 kcal, 67 grams fat, 33 grams protein, 58 grams carbohydrate) reduced plasma amprenavir AUC(0-∞) by 28% and Cmax by 46% and delayed Tmax by 0.72 hours.
Slovenian: Dajanje fosamprenavirja v obliki peroralne suspenzije skupaj z obrokom z veliko količino maščob (967 kcal, 67 g maščobe, 33 g beljakovin, 58 g ogljikovih hidratov) je plazemsko AUC amprenavirja (0-) zmanjšalo za 28 %, cmax za 48 % in tmax zakasnilo za 0,72 ure.
English: The pharmacokinetic properties of amprenavir following co-administration of Telzir with ritonavir have been evaluated in healthy adult subjects and HIV-infected patients and no substantial differences were observed between these two groups.
Slovenian: Farmakokinetične lastnosti amprenavirja po sočasnem dajanju zdravila Telzir skupaj z ritonavirjem so bile ovrednotene tako pri zdravih odraslih osebah kot pri z virusom HIV okuženih bolnikih.
English: When antineoplastic agents that are metabolised by CYP3A are co-administered with fosamprenavir/ritonavir, plasma concentrations of these antineoplastic medications may be increased and could increase the risk of adverse events usually associated with these antineoplastic agents.
Slovenian: Pri sočasni uporabi antineoplastičnih učinkovin, ki se metabolizirajo s CYP3A in fosamprenavirja/ritonavirja, so lahko koncentracije teh antineoplastičnih zdravil v plazmi povečane; to lahko poveča tveganje za neželene učinke, ki so običajno povezani s temi antineoplastičnimi učinkovinami.
English: ANTIRETROVIRAL MEDICINAL PRODUCTS
Slovenian: PROTIRETROVIRUSNA ZDRAVILA
English: The recommended dose is 0.36 ml/kg of Telzir oral suspension (18 mg per kg fosamprenavir) twice daily with 3 mg/kg ritonavir oral solution twice daily.
Slovenian: Priporočeni odmerek je 0,36 ml/kg peroralne suspenzije Telzir (18 mg fosemprenavirja na kg) dvakrat na dan skupaj s 3 mg/kg peroralne raztopine ritonavirja dvakrat na dan.
English: Do not leave the syringe in the bottle.
Slovenian: Odmerne brizge ne smete pustiti pritrjene na plastenko.
English: Nevirapine 200 mg twice daily
Slovenian: nevirapin 200 mg dvakrat dnevno
English: No dosage adjustment necessary with antacids, proton-pump inhibitors or histamine H2 receptor antagonists.
Slovenian: Odmerkov ni potrebno prilagajati z antacidi, antagonisti histaminskih receptorjev H2 ali zaviralci protonske črpalke.
English: Median Change from baseline in CD4 cells (cells/µl)
Slovenian: Srednja sprememba od izhodiščne vrednosti števila CD4 celic (celice/l)
English: Oral suspension should be taken with food 25-32 kg Oral suspension
Slovenian: 25-32 kg Peroralna suspenzija
English: The mutational profiles were similar to those described for PIexperienced adults treated with fosamprenavir / ritonavir.
Slovenian: Profili mutacij so bili podobni tistim pri odraslih bolnikih, ki so se predhodno že zdravili z zaviralci proteaz in so se zdravili s fosamprenavirjem/ritonavirjem.
English: Your doctor will work out the right dose based on your weight.
Slovenian: Natančen odmerek bo določil zdravnik na osnovi telesne mase.
English: Some people taking medicines for HIV infection develop other conditions, which can be serious.
Slovenian: Pri posameznih bolnikih lahko med jemanjem zdravil za zdravljenje okužbe z virusom HIV pride do pojava stanja, ki je lahko resno.
English: After multiple dose oral administration of fosamprenavir 700 mg with ritonavir 100 mg twice daily, amprenavir was rapidly absorbed with a geometric mean (95 % CI) steady state peak plasma amprenavir concentration (Cmax) of 6.08 (5.38-6.86) µg/ml occurring approximately 1.5 (0.75-5.0) hours after dosing (tmax).
Slovenian: Po večkratnem peroralnem dajanju fosamprenavirja v odmerku 700 mg skupaj z ritonavirjem v odmerku 100 mg dvakrat dnevno se je amprenavir hitro absorbiral, pri čemer so se geometrične srednje (95 % interval zaupanja) najvišje plazemske koncentracije v stanju dinamičnega ravnovesja (Cmax) 6,08 (5,38-6,86) µg/ml pojavile približno po 1,5 (0,75-5,0) urah po dajanju (tmax).
English: • maraviroc (used to treat HIV infection)
Slovenian: • maravirok (uporabljamo ga za zdravljenje okužbe z virusom HIV)
English: ANTACIDS, HISTAMINE H2 RECEPTOR ANTAGONIST AND PROTON-PUMP INHIBITORS
Slovenian: ANTACIDI, ANTAGONISTI HISTAMINSKIH RECEPTORJEV H2 IN ZAVIRALCI PROTONSKE ČRPALKE
English: The adverse reaction profile of Telzir should be borne in mind when considering the patient's ability to drive or operate machinery (see section 4.8).
Slovenian: Pri presojanju bolnikovih sposobnosti za vožnjo in upravljanje strojev je potrebno upoštevati profil neželenih reakcij zdravila Telzir (glejte poglavje 4.8).
English: Rash / cutaneous reactions: erythematous or maculopapular cutaneous eruptions, with or without pruritus, may occur during therapy.
Slovenian: Eksantem/kožne reakcije: Med zdravljenjem se lahko pojavijo eritematozne ali makulopapularne kožne erupcije s srbežem ali brez.
English: Telzir with ritonavir is not recommended in children below 6 years due to insufficient data on pharmacokinetics, safety and antiviral response (see section 5.2).
Slovenian: Otroci, mlajši od 6 let zdravilo Telzir v kombinaciji z ritonavirjem zaradi pomanjkljivih podatkov o farmakokinetiki, varnosti in in protivirusnemu odzivu ni priporočljiv za otroke, mlajše od 6 let (glejte poglavje 5.2).
English: Your doctor may lower your dose of Telzir and ritonavir depending on the amount of liver damage.
Slovenian: Zdravnik lahko glede na obseg okvare jeter zmanjša odmerek zdravila Telzir in ritonavirja.
English: Telzir does not require any other special storage conditions.
Slovenian: Za shranjevanje zdravila Telzir niso potrebna druga posebna navodila.
English: The plasma amprenavir pharmacokinetics were evaluated in a 14 day repeat-dose study in HIV-1 infected adult subjects with mild, moderate, or severe hepatic impairment receiving fosamprenavir with ritonavir compared to matched control subjects with normal hepatic function.
Slovenian: Pri z virusom HIV-1 okuženih odraslih osebah z blago, zmerno ali hudo jetrno okvaro je bila izvedena 14-dnevna študija s ponavljajočimi se odmerki, ki je ovrednotila plazemsko farmakokinetiko amprenavirja pri uporabi fosamprenavirja v kombinaciji z ritonavirjem v primerjavi s primerljivimi kontrolnimi osebami z normalnim delovanjem jeter.
English: Ergonovine: ↑ expected Ergotamine: ↑ expected Methylergonovine: ↑ expected
Slovenian: dihidroergotamin ergotamin ergonovin metilergonovin dihidroergotamin:  pričakovano ergonovin:  pričakovano ergotamin:  pričakovano metilergonovin:  pričakovano
English: fosamprenavir/ritonavir, plasma concentrations of these antineoplastic medications may be increased and could increase the risk of adverse events usually associated with these antineoplastic agents.
Slovenian: so lahko koncentracije teh antineoplastičnih zdravil v plazmi povečane; to lahko poveča tveganje za neželene učinke, ki so običajno povezani s temi antineoplastičnimi učinkovinami.
English: Unless otherwise stated, studies detailed below have been performed with the recommended dosage of fosamprenavir/ritonavir (i.e. 700/100 mg twice daily), and the interaction was assessed under steadystate conditions where drugs were administered for 10 to 21 days.
Slovenian: Če ni drugače navedeno, so bile navedene študije izvedene s priporočenimi odmerki fosamprenavirja/ritonavirja (700/100 mg dvakrat dnevno) in interakcije so bile ocenjene v stanju dinamičnega ravnovesja, kjer je bilo zdravilo aplicirano 10 do 21 dni.
English: A reduction in the rifabutin dosage by at least 75 % is recommended when administered with Telzir with ritonavir.
Slovenian: Pri sočasnem dajanju rifabutina ter zdravila Telzir v kombinaciji z ritonavirjem je priporočljivo, da se odmerek rifabutina zmanjša vsaj za 75 %.
English: Shake the bottle for 5 seconds before subsequent uses.
Slovenian: Pred vsako naslednjo uporabo plastenko stresajte 5 sekund.
English: 25-O-desacetylrifabutin: Cmax ↑ 6-fold* 25-O-desacetylrifabutin: AUC(0-48) ↑ 11-fold* *compared to rifabutin 300 mg once daily
Slovenian: 25-O-dezacetilrifabutin: Cmax6-krat* 25-O-dezacetilrifabutin: AUC(0-48)  11krat* *primerjava z rifabutin 300 mg enkrat dnevno
English: 225 ml oral suspension A 10 ml graduated dosing syringe and adapter are also provided in the pack
Slovenian: 225 ml peroralne suspenzije V škatli je priložena tudi 10 ml umerjena odmerna brizga in nastavek.
English: In long-term carcinogenicity studies with fosamprenavir in mice and rats, there were increases in hepatocellular adenomas and hepatocellular carcinomas in mice at exposure levels equivalent to 0.1 to 0.3-fold those in humans given 700 mg of fosamprenavir plus 100 mg ritonavir twice daily, and increases in hepatocellular adenomas and thyroid follicular cell adenomas in rats at exposure levels equivalent to 0.3 to 0.6-fold those in humans given 700 mg of fosamprenavir plus 100 mg ritonavir twice daily.
Slovenian: Pri dolgotrajnih študijah kancerogenosti fosamprenavirja na miših in podganah so pri miših pri izpostavljenosti, ki je ustrezala 0,1- do 0,3-kratni izpostavljenosti pri človeku pri uporabi fosamprenavirja v odmerku 700 mg in ritonavirja v odmerku 100 mg dvakrat na dan, opazili večjo pojavnost hepatocelularnih adenomov in hepatocelularnih karcinomov, pri podganah pa pri izpostavljenosti, ki je ustrezala 0,3- do 0,6-kratni izpostavljenosti pri človeku pri uporabi fosamprenavirja v odmerku 700 mg in ritonavirja v odmerku 100 mg dvakrat na dan, večjo pojavnost hepatocelularnih adenomov in folikularnih adenomov ščitnice.
English: Rifabutin: Cmax ↓ 14%* Rifabutin: AUC(0-48) ↔*
Slovenian: rifabutin 150 mg vsak drug dan rifabutin: Cmax  14%* rifabutin: AUC(0-48) *
English: Cyclosporin: ↑ expected Rapamycin: ↑ expected Tacrolimus: ↑ expected
Slovenian: ciklosporin:  pričakovano rapamicin:  pričakovano takrolimus:  pričakovano
English: Headache, dizziness, oral paraesthesia
Slovenian: Bolezni živčevja glavobol, omotica, oralna parestezija pogosti
English: Slowly push the plunger in, allowing time to swallow.
Slovenian: Počasi pritiskajte na bat, da boste imeli dovolj časa, da lahko zdravilo pogoltnete.
English: Clinical experience with fosamprenavir boosted with ritonavir is mainly based on two open label studies, one in antiretroviral naïve patients (study ESS100732), and one study in antiretroviral experienced patients (study APV30003).
Slovenian: Klinične izkušnje z uporabo fosamprenavirja skupaj z ritonavirjem v glavnem temeljijo na dveh odprtih študijah, ena pri bolnikih, ki predhodno še niso bili zdravljeni s protiretrovirusnimi zdravili (študija ESS100732) in ena pri bolnikih, ki so predhodno že bili zdravljeni s protiretrovirusnimi zdravili (študija APV30003).
English: • raltegravir (used to treat HIV infection)
Slovenian: • raltegravir (uporabljamo ga za zdravljenje okužbe z virusom HIV)
English: 400 mg twice daily
Slovenian: 400 mg dvakrat dnevno
English: Combination of rifampicin with Telzir with concomitant low-dose ritonavir is contraindicated (see section 4.5).
Slovenian: Kombinacija rifampicina in zdravila Telzir skupaj z nizkim odmerkom ritonavirja je kontraindicirana (glejte poglavje 4.5).
English: In patients with haemophilia type A and B, there have been reports of increased bleeding while taking protease inhibitors.
Slovenian: Pri bolnikih s hemofilijo se lahko pojavijo hujše krvavitve Pri bolnikih s hemofilijo tipa A in B so med jemanjem zaviralcev proteaz poročali o hujših krvavitvah.
English: For adults with severe hepatic impairment (Child-Pugh score: 10-15): fosamprenavir should be used with caution and at a reduced dose of 300 mg fosamprenavir twice daily with 100 mg ritonavir once daily.
Slovenian: Pri odraslih s hudo jetrno okvaro (ocena po Child-Pugh-u: 10-15): fosamprenavir je potrebno uporabljati previdno in v manjšem odmerku 300 mg fosamprenavirja dvakrat na dan s 100 mg ritonavirjem enkrat na dan.
English: In this patient population, the oral suspension should be taken without food and on an empty stomach.
Slovenian: V tej skupini bolnikov je treba peroralno suspenzijo vzeti brez hrane in na prazen želodec.
English: Co-administration of TELZIR/ritonavir with alfuzosin is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba zdravila TELZIR/ritonavir z alfuzosinom je kontraindicirana (glejte poglavje 4.3).
English: Glaxo Wellcome Operations, Priory Street, Ware, Hertfordshire SG12 0DJ, United Kingdom Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero Burgos, Spain Oral suspension
Slovenian: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero Burgos, Španija Peroralna suspenzija
English: Drugs by Therapeutic Area Interaction
Slovenian: Zdravila po terapevtski skupini
English: Pup survival was decreased.
Slovenian: Mladiči, ki so preživeli, so bili manjši.
English: In the studies of PI-experienced adult patients, PRO30017 (amprenavir 600 mg / ritonavir 100 mg twice daily in sub-study A and B with 80 and 37 patients respectively), the following mutations emerged in patients with virological failure: L10F/I/V, V11I, I13V, K20R, V32I, L33F, E34Q, M36I, M46I/L, I47V, G48V, I50V, I54L/M/T/V, Q58E, D60E, I62V, A71V, V77I, V82A/I, I84V, I85V, L90M and I93L/M.
Slovenian: V študijah odraslih bolnikov, ki so že bili zdravljeni z zaviralci proteaz, PRO30017 (amprenavir 600 mg / ritonavir 100 mg dvakrat na dan in podštudijah A in B, v katere je bilo vključenih 80 oziroma 37 bolnikov), so se pri bolnikih z virusnim neodzivom pojavile naslednje mutacije: L10F/I/V, V11I, I13V, K20R, V32I, L33F, E34Q, M36I, M46I/L, I47V, G48V, I50V, I54L/M/T/V, Q58E, D60E, I62V, A71V, V77I, V82A/I, I84V, I85V, L90M in I93L/M.
English: Fosamprenavir tablets and oral suspension with ritonavir in combination with NRTIs have been evaluated in protease inhibitor naïve and experienced children and adolescent patients.
Slovenian: Uporaba fosamprenavirja v obliki tablet in peroralne suspenzije skupaj z ritonavirjem v kombinaciji z zdravljenjem z NRTI je bila v dveh študijah ovrednotena pri otrocih in mladostnikih, ki so so že bili oziroma še niso bili zdravljeni z zaviralci proteaz.
English: Children from 6 years of age and weighing at least 39 kg Children can take the adult tablet dose of one 700 mg Telzir tablet twice daily with ritonavir 100 mg twice daily if they can swallow the tablets whole.
Slovenian: Otroci od 6. leta starosti in s telesno maso vsaj 39 kg Otroci lahko dobijo odmerek za odrasle - eno 700 mg tableto zdravila Telzir dvakrat na dan in 100 mg ritonavirja dvakrat na dan - če lahko tablete pogoltnejo cele.
English: Industriestrasse 32-36 D-23843 Bad Oldesloe Germany or
Slovenian: Aspen Bad Oldesloe GmbH Industriestrasse 32-36 D-23843 Bad Oldesloe Nemčija ali
English: The median durations of prior exposure to NRTIs were 257 weeks for patients receiving fosamprenavir with ritonavir twice daily (79 % had ≥ 3 prior NRTIs) and 210 weeks for patients receiving lopinavir/ritonavir (64 % had ≥ 3 prior NRTIs).
Slovenian: Bolniki, ki so prejemali fosamprenavir v kombinaciji z ritonavirjem dvakrat dnevno, so bili pred tem v povprečju 257 tednov izpostavljeni NRTI (79 % izmed njih ≥ 3 NRTI), bolniki, ki so prejemali lopinavir/ritonavir pa 210 tednov (64 % izmed njih ≥ 3 NRTI).
English: GASTROINTESTINAL MOTILITY AGENTS
Slovenian: ZDRAVILA ZA GASTROINTESTINALN O MOTILITETO