FrancophonIA/ELRC3.0 huggingface dataset:
English: Package Leaflet: Information for the user Helixate NexGen 3000 IU powder and solvent for solution for injection Recombinant coagulation factor VIII (octocog alfa)
Slovenian: Navodilo za uporabo Helixate NexGen 3000 i.e. prašek in vehikel za raztopino za injiciranje rekombinantni koagulacijski faktor VIII (oktokog alfa)
English: Warnings and precautions Talk to your doctor or pharmacist before using Helixate NexGen 2000 IU.
Slovenian: Pred začetkom uporabe zdravila Helixate NexGen 2000 i.e. se posvetujte s svojim zdravnikom ali farmacevtom.
English: Package Leaflet: Information for the user Helixate NexGen 1000 IU powder and solvent for solution for injection Recombinant coagulation factor VIII (octocog alfa)
Slovenian: Navodilo za uporabo Helixate NexGen 1000 i.e. prašek in vehikel za raztopino za injiciranje rekombinantni koagulacijski faktor VIII (oktokog alfa)
English: MARKETING AUTHORISATION NUMBER(S) EU/1/00/144/004
Slovenian: ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/00/144/004
English: Helixate NexGen is provided as a powder and solvent for solution for injection and is a dry white to slightly yellow powder or cake.
Slovenian: Zdravilo Helixate NexGen 250 i.e. je na voljo kot prašek (suh, bel do rahlo rumen prašek ali pogača)
English: Check with your doctor or pharmacist if you are not sure.
Slovenian: Če ste negotovi, se posvetujte s svojim zdravnikom ali farmacevtom.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/00/144/003
Slovenian: ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/00/144/003
English: Desired plasma FVIII level
Slovenian: nastanek inhibitorjev proti FVIII
English: The formation of neutralising antibodies (inhibitors) to factor VIII is a known complication in the management of individuals with haemophilia A. These inhibitors are usually IgG immunoglobulins directed against the factor VIII procoagulant activity, which are quantified in Bethesda Units (BU) per ml of plasma using the modified assay.
Slovenian: Primer izračuna hitrosti infundiranja kontinuirane infuzije po začetni bolusni injekciji želena aktivnost FVIII v plazmi hitrost infundiranja i.e./h/kg hitrost infundiranja za 75 kg bolnika ml/h očistek:
English: (See section also 3 “How to take <product name>” for further advice).
Slovenian: (Glej tudi poglavje 3 "Kako jemati zdravilo <ime zdravila>" za nadaljnje nasvete).
English: Do not delay taking the tablet.
Slovenian: Z uporabo tablete ne smete odlašati.
English: Annex III Amendments to the relevant sections of the Product information
Slovenian: Priloga III Sprememba ustreznih poglavij v informacijah o zdravilu
English: Do not chew but swallow the tablet whole with water.
Slovenian: Tablete ne smete žvečiti, temveč jo morate pogoltniti celo, z vodo.
English: If you use these medicines take [number of] tablets of <product name>.
Slovenian: Če uporabljate ta zdravila, vzemite [število tablet] tablet zdravila <ime zdravila>.
English: Section 4.2 Posology and method of administration [The wording below should be inserted in this section]
Slovenian: Poglavje 4.2 Odmerjanje in način uporabe [Spodnje besedilo je treba vstaviti v to poglavje]
English: The tablet works best better the sooner you take it after having unprotected sex.
Slovenian: Tableta učinkuje najbolje tem bolje, čim prej po nezaščitenem spolnem odnosu jo vzamete.
English: • If you are already using a regular method of contraception such as the contraceptive pill, you can continue to take this at your regular times.
Slovenian: • Če že uporabljate redno zaščito pred nosečnostjo, kot je npr. kontracepcijska tableta, lahko nadaljujete z običajnim jemanjem tablet.
English: Speak to your pharmacist or doctor if you need further advice on the correct dose for you.
Slovenian: Pogovorite se s farmacevtom ali zdravnikom, če potrebujete dodatne nasvete o pravilnem odmerku za vas.
English: Concomitant administration of efavirenz has been found to reduce plasma levels of levonorgestrel (AUC) by around 50%.
Slovenian: Pri sočasni uporabi z efavirenzom so ugotovili za približno 50% nižje plazemske ravni (AUC) levonorgestrela.
English: <product name> may also affect how well other medicines work - a medicine called cyclosporin (suppresses the immune system).
Slovenian: Zdravilo <ime zdravila> lahko tudi vpliva na to, kako dobro delujejo druga zdravila: - zdravilo, imenovalno ciklosporin (zavira imunski sistem)
English: • If you are using one of the medicines that may prevent <product name> from working properly (see section above “Other medicines and <product name>”) or if you have used one of these medicines in the past 4 weeks, <product name> may work less effectively for you.
Slovenian: • Če uporabljate eno od zdravil, ki lahko prepreči pravilno delovanje <ime zdravila> (glejte poglavje zgoraj "Druga zdravila in zdravilo<ime zdravila>") ali če ste uporabili eno od teh zdravil v zadnjih 4 tednih, lahko <ime zdravila > pri vas deluje manj učinkovito.
English: Some medicines may prevent <product name> from working properly effectively these include.
Slovenian: Nekatera zdravila lahko preprečijo, da zdravilo <ime zdravila> deluje pravilno učinkovito.
English: The metabolism of levonorgestrel is enhanced by concomitant use of liver enzyme inducers, mainly CYP3A4 enzyme inducers.
Slovenian: Presnova levonorgestrela se okrepi ob sočasni uporabi induktorjev jetrnih encimov, zlasti induktorji encimov CYP3A4.
English: [The wording in this section should be amended as below]
Slovenian: [Besedilo v tem poglavju je treba spremeniti, kot sledi]
English: - barbiturates and other medicines (used to treat epilepsy (for example, primidone, phenytoin, and carbamazepine) - medicines used to treat tuberculosis (for example, rifampicin, rifabutin) - a treatment for HIV infection (ritonavir, efavirenz) - a medicine used to treat fungal infections (griseofulvin) - herbal remedies containing St John's wort (Hypericum perforatum) - a medicine called cyclosporin (suppresses the immune system).
Slovenian: - barbiturati in druga zdravila (za zdravljenje epilepsije (npr. primidon, fenitoin in karbamazepin), - zdravila za zdravljenje tuberkuloze (npr. rifampicin, rifabutin), - zdravila za zdravljenje okužbe z virusom HIV (ritonavir, efavirenz), - zdravilo, s katerim zdravimo okužbe z glivicami (grizeofulvin), - zdravila rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum), - zdravilo ciklosporin (zavira imunski sistem).
English: Other medicines and Levonelle 1500 [The wording below should be amended in this section] Tell your pharmacist or doctor if you are taking or have recently taken or might take any other medicines, including medicines obtained without a prescription or herbal medicines.
Slovenian: Druga zdravila in zdravilo <ime zdravila> [Besedilo v tem poglavju je treba spremeniti, kot sledi] Obvestite svojega farmacevta ali zdravnika, če jemljete ali ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo, vključno z zdravili brez recepta ali zdravili rastlinskega izvora.
English: If you are unsure or to ask for an alternative treatment speak to your doctor or pharmacist before using <product name>.”
Slovenian: Če niste prepričani ali če želite drugačno zdravljenje, se pogovorite s svojim zdravnikom ali farmacevtom, preden uporabite zdravilo <ime zdravila>. "
English: Drugs suspected of having the similar capacity to reduce the efficacy of levonorgestrel containing medication due to similar effects on plasma levels of levonorgestrel include barbiturates (including primidone), phenytoin, carbamazepine, herbal medicines containing Hypericum perforatum (St. John's Wort), rifampicin, ritonavir, rifabutin, and griseofulvin.
Slovenian: Med zdravili, ki domnevno lahko podobno zmanjšajo plazemske ravni zmanjšajo učinkovitost zdravil, ki vsebujejo levonorgestrel levonorgestrela, so barbiturati (vključno s primidonom), fenitoin, karbamazepin, zdravila rastlinskega izvora, ki vsebujejo Hypericum perforatum (šentjanževko), rifampicin, ritonavir, rifabutin in grizeofulvin.
English: “If you have used certain other medicines in the last 4 weeks, in particular treatment for epilepsy, tuberculosis, for HIV infection or herbal medicines containing St. John´s wort (see leaflet), <product name> may work less effectively.
Slovenian: "Če ste v zadnjih 4 tednih uporabljali določena druga zdravila, zlasti za zdravljenje epilepsije, tuberkuloze, za okužbe z virusom HIV ali zdravila rastlinskega izvora, ki vsebujejo šentjanževko (glej navodilo), je lahko <ime zdravila> manj učinkovito.
English: Speak to your pharmacist or doctor if you need further advice.
Slovenian: Pogovorite se z zdravnikom ali s farmacevtom, če potrebujete dodatne nasvete.
English: Taking a double dose of levonorgestrel (i.e. 3000 mcg within 72 hours after the unprotected intercourse) is an option for women who are unable or unwilling to use a Cu-IUD, although this specific combination (a double dose of levonorgestrel during concomitant use of an enzyme inducer) has not been studied.
Slovenian: 3000 mcg v 72 urah po nezaščitenem spolnem odnosu) je možnost za ženske, ki ne morejo ali ne želijo uporabiti Cu-IUD, čeprav ta posebna kombinacija (dvojni odmerek levonorgestrela med sočasno uporabo induktorjev encimov) ni raziskana.
English: C. Package leaflet
Slovenian: Predlagana ovojnina
English: If you have used any of the medicines below during the last 4 weeks, <product name> may be less suitable for you.
Slovenian: vključno s spodaj naštetimi Če ste v zadnjih 4 tednih uporabili katero od spodaj naštetih zdravil, je zdravilo <ime zdravila> morda manj primerno za vas.
English: Your doctor may prescribe another type of (non-hormonal) emergency contraceptive, i.e. a copper intrauterine device (Cu-IUD).
Slovenian: Zdravnik vam lahko predpiše drugo vrsto (ne hormonske) nujne kontracepcije, tj. bakreni maternični vložek (Cu-IUD).
English: For women who need levonorgestrel emergency contraception whilst using or and who have used enzyme-inducing drugs in the past 4 weeks and need emergency contraception, the use of nonhormonal emergency contraception (i.e. a Cu-IUD) should be considered.
Slovenian: Pri ženskah ki potrebujejo nujno kontracepcijo levonorgestrela med uporabo ali in, ki so v zadnjih 4 tednih uporabljale zdravila, ki inducirajo encime in potrebujejo nujno kontracepcijo, je potrebno razmisliti o uporabi nehormonske nujne kontracepcije (npr. bakrenega materničnega vložka (Cu-IUD)).
English: Consult your doctor as soon as possible after taking the tablets for further advice on a reliable form of regular contraception and to exclude a pregnancy.before using Levonelle 1500 if you use any of the above mentioned medicines.
Slovenian: Po jemanju teh tablet se čim prej posvetujte z zdravnikom za nadaljnje nasvete o zanesljivih oblikah redne kontracepcije in da izključite nosečnost.
English: If this is not an option for you or if you are unable to see your doctor promptly, you can take a double dose of <product name>:
Slovenian: Če to ne pride v poštev za vas ali če ne morete takoj obiskati zdravnika, lahko vzemite dvojni odmerek zdravila <ime zdravila>:
English: A. Summary of Product Characteristics
Slovenian: Povzetek glavnih značilnosti zdravila (SmPC)
English: Medicines containing levonorgestrel may increase the risk of cyclosporin toxicity due to possible inhibition of cyclosporin metabolism.
Slovenian: Zdravila, ki vsebujejo levonorgestrel, utegnejo zavreti presnovo ciklosporina in s tem povečati tveganje za njegovo toksičnost.
English: If this is not an option for you or if you are unable to see your doctor promptly, you can take a double dose of <product name> (i.e. 2 tablets taken together at the same time).
Slovenian: Če to ne pride v poštev za vas ali če ne morete takoj obiskati zdravnika, lahko vzemite dvojni odmerek zdravila <ime zdravila> (t.j.
English: How to take Levonelle 1500 [The wording below should be amended in this section] Always use this medicine exactly as described in the leaflet or as your pharmacist has told you.
Slovenian: Kako jemati <ime zdravila> [Besedilo v tem poglavju je treba spremeniti, kot sledi] Pri jemanju tega zdravila natančno upoštevajte napotke v tem navodilu ali navodila farmacevta.
English: • Take the tablet as soon as possible, preferably within 12 hours, and no later than 72 hours (3 days) after you have had unprotected sex. <product name> can be taken at any time in your menstrual cycle assuming you are not already pregnant or think you may be pregnant.
Slovenian: • Vzemite tableto čim prej, najbolje v 12 urah, najpozneje pa v 72 urah (3 dneh) po nezaščitenem spolnem odnosu.
English: Women who have used enzyme-inducing drugs during the last 4 weeks and need emergency contraception are recommended to use a non-hormonal EC, i.e. Cu-IUD or take a double dose of levonorgestrel (i.e. 2 tablets taken together) for those women unable or unwilling to use Cu-IUD (see section 4.5).
Slovenian: bakrenega materničnega vložka (Cu-IUD) ali dvojnega odmerka levonorgestrela (to je 2 tableti skupaj) za ženske, ki ne morejo ali ne želijo uporabiti Cu-IUD (glejte poglavje 4.5).
English: What you need to know before you take Levonelle 1500
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo <ime zdravila>
English: OTHER SPECIAL WARNING(S), IF NECESSARY
Slovenian: DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA [Spodnje besedilo je treba vstaviti v to poglavje]
English: Also do not use tools or machines if you feel very sleepy - or do anything else which may put others or yourself at risk of serious injury.
Slovenian: Prav tako ne uporabljajte orodja ali upravljajte strojev, če ste zelo zaspani - oziroma ne počnite ničesar, kar bi lahko v nevarnost za resne poškodbe spravilo vas ali druge.
English: If any of the above apply to you, do not use Neupro.
Slovenian: Če kaj od zgoraj navedenega velja za vas, ne uporabljajte zdravila Neupro.
English: • altered or increased sexual interest and behaviour which causes significant concern to you or others - for example, an increased sex drive
Slovenian: • spremenjena ali povečana želja po spolnosti in vedenje, ki je zaskrbljujoče za vas ali druge - na primer povečan spolni nagon
English: These packages are usually needed for the first four weeks of therapy, but depending on your response to Neupro, you may not need to use all of the dose packages included or you may need additional higher doses after week 4, which are not covered by this package.
Slovenian: Ta pakiranja se ponavadi potrebujejo za prve štiri tedne zdravljenja, vendar odvisno od vašega odziva na zdravilo Neupro morda ne boste uporabili vseh priloženih pakiranj ali pa boste potrebovali dodatne večje odmerke po 4. tednu, ki jih v tem pakiranju ni.
English: In isolated cases “sudden onset of sleep” occurred while driving and resulted in motor vehicle accidents (see also sections 4.4 and 4.7).
Slovenian: V posameznih primerih je nastopil "nenaden spanec" med vožnjo, zaradi katerega so se zgodile prometne nesreče (glejte tudi poglavji 4.4 in 4.7).
English: • Keep it pressed for about 30 seconds.
Slovenian: • Pritiskajte približno 30
English: Do not take the following medicines while using Neupro - because they may decrease its effect:
Slovenian: Naslednjih zdravil ne jemljite med uporabo zdravila Neupro, saj lahko zmanjšajo njegov učinek:
English: • your blood pressure needs checking regularly while using Neupro, especially at the start of the treatment.
Slovenian: • potrebujete redne meritve krvnega tlaka med uporabo zdravila Neupro, zlasti na začetku zdravljenja.
English: • Parkinson's disease - Neupro can be used on its own or with another medicine called levodopa.
Slovenian: • Parkinsonove bolezni - zdravilo Neupro se lahko uporablja samostojno ali z drugim zdravilom, imenovanim levodopa.
English: Date of first authorisation: 15 February 2006 Date of latest renewal: 22 January 2016
Slovenian: Datum zadnjega podaljšanja dovoljenja za promet:22. januar 2016
English: BOX OF 7 [14] [28] [30] PATCHES
Slovenian: ŠKATLA S 7 [14] [28] [30] OBLIŽI
English: Neupro should not be placed on skin that is red, irritated or damaged (see section 4.4).
Slovenian: Zdravila Neupro ne smemo namestiti na rdečo, razdraženo ali poškodovano kožo (glejte poglavje 4.4).
English: What you need to know before you use Neupro
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Neupro
English: • Do not stick the patch on broken or damaged skin - or on skin that is red or irritated.
Slovenian: • Obliža zdravila Neupro ne uporabite na razpokani ali poškodovani koži - ali na koži, ki je pordela ali razdražena.
English: The efficacy of rotigotine was evaluated in 5 placebo-controlled trials with more than 1,400 patients with idiopathic Restless Legs Syndrome (RLS).
Slovenian: Učinkovitost rotigotina so ocenili v petih s placebom kontroliranih študijah z več kot 1.400 bolniki z idiopatičnim sindromom nemirnih nog (RLS - Restless Legs Syndrom).
English: If there is a skin rash or irritation from the transdermal system, direct sunlight on the area should be avoided until the skin heals, as exposure could lead to changes in the skin color.
Slovenian: Če se zaradi transdermalnega sistema pojavijo kožni izpuščaji ali je koža razdražena, se je treba izogibati izpostavljanju tega mesta neposredni sončni svetlobi, dokler se koža ne zaceli, saj lahko izpostavljanje povzroči spremembe barve kože.
English: • you may feel very sleepy or fall asleep suddenly - see ‘Driving and using machines' in section 2.
Slovenian: • lahko postanete zelo zaspani ali nenadno zaspite - glejte 'Vpliv na sposobnost upravljanja vozil in strojev'v poglavju 2.
English: You should take Neupro 2 mg for 7 days (e.g. if you start on a Sunday, switch to the next dose on the following Sunday).
Slovenian: Zdravilo Neupro 2 mg jemljite 7 dni (npr. če začnete v nedeljo, preidite na naslednji odmerek naslednjo nedeljo).
English: • craving large doses of medicines like Neupro - more than needed for the illness.
Slovenian: • hrepenenje po velikih odmerkih zdravil, kot je zdravilo Neupro - več kot je potrebno za zdravljenje bolezni.
English: If you experience such symptoms either before or after beginning treatment with Neupro, contact your doctor as your treatment may need to be adjusted.
Slovenian: Če se pri vas pojavijo takšni simptomi pred ali po začetku zdravljenja z zdravilom Neupro, se posvetujte z zdravnikom, saj bo vaše zdravljenje morda treba prilagoditi.
English: Neupro is available in the following pack-sizes:
Slovenian: Zdravilo Neupro je na voljo v naslednjih velikostih pakiranja:
English: Neupro may decrease blood pressure when you stand up this effect may be worsened by the medicines used to lower blood pressure.
Slovenian: Zdravilo Neupro lahko zniža krvni tlak, ko vstanete - ta učinek se lahko poslabša ob jemanju zdravila za zniževanje krvnega tlaka.
English: The dose of Neupro will depend on your illness - see below.
Slovenian: Odmerek zdravila Neupro bo odvisen od vaše bolezni - glejte spodaj.
English: If you stop using Neupro
Slovenian: Če ste prenehali uporabljati zdravilo Neupro
English: Neupro may potentiate the dopaminergic adverse reaction of L-dopa and may cause and/or exacerbate pre-existing dyskinesia, as described with other dopamine agonists.
Slovenian: Zdravilo Neupro lahko okrepi dopaminergične neželene učinke L-dope ter povzroči in/ali poslabša obstoječo diskinezijo, kot je opisano pri drugih agonistih dopamina.
English: If you have used a different patch (e.g. Neupro 4 mg/24 h instead of Neupro 2 mg/24 h) than your doctor told you to, contact your doctor or hospital for advice immediately, and follow their advice on changes of patches.
Slovenian: Če ste uporabili drugačen obliž (npr. Neupro 4 mg/24 h, namesto Neupro 2 mg/24 h), kot vam je predpisal zdravnik, takoj obvestite svojega zdravnika ali bolnišnico in sledite njihovemu navodilu za odstranitev obližev.
English: Other medicines and Neupro
Slovenian: Druga zdravila in zdravilo Neupro
English: You should discuss with your doctor if it is safe for you to drink alcohol while using Neupro.
Slovenian: Posvetujte se z zdravnikom, če je varno, da med uporabo zdravila Neupro pijete alkohol.
English: Your doctor will let you know if it is safe to keep taking these medicines while using Neupro.
Slovenian: Zdravnik vam bo svetoval, če je varno jemati ta zdravila med zdravljenjem z zdravilom Neupro.
English: This is normally reached within 3 to 4 weeks.
Slovenian: Ta odmerek se ponavadi doseže v 3 do 4 tednih.
English: Neupro may affect your blood pressure.
Slovenian: Zdravilo Neupro lahko vpliva na vaš krvni tlak.
English: 4 mg of Neupro every day may be an effective dose for some patients.
Slovenian: 4 mg zdravila Neupro vsak dan je lahko učinkovit odmerek za nekatere bolnike.
English: • you need to have a magnetic resonance imaging (MRI) scan (diagnostic pictures of the inside of the body, created using magnetic rather than x-ray energy)
Slovenian: • vam bodo opravili magnetnoresonančno slikanje (MRI) (diagnostična slika notranje zgradbe telesa, narejena z uporabo magnetne energije namesto energije rentgenskih žarkov)
English: What Neupro is and what it is used for
Slovenian: Kaj je zdravilo Neupro in za kaj ga uporabljamo
English: Neupro can cause side effects that change your behaviour (how you act).
Slovenian: Zdravilo Neupro lahko povzroči neželene učinke in spremeni vaše vedenje (obnašanje).
English: Because rotigotine is a dopamine agonist, it is assumed that dopamine antagonists, such as neuroleptics (e.g. phenothiazines, butyrophenones, thioxanthenes) or metoclopramide, may diminish the effectiveness of Neupro, and co-administration should be avoided.
Slovenian: Rotigotin je agonist dopamina, zato se predpostavlja, da lahko antagonisti dopamina, kot so nevroleptiki (npr. fenotiazini, butirofenoni, tioksanteni) ali metoklopramid, zmanjšajo učinkovitost zdravila Neupro in se je treba njihovi sočasni uporabi izogibati.
English: UCB Pharma S.A. Chemin du Foriest B-1420 Braine l'Alleud Belgium
Slovenian: UCB Pharma S.A. Chemin du Foriest B-1420 Braine l'Alleud Belgija
English: Because therapy with Neupro is initiated at a low dose and gradually titrated according to clinical tolerability to obtain the optimum therapeutic effect, adjustment of the dose based on gender, weight, or age is not necessary.
Slovenian: Zdravljenje z zdravilom Neupro se začne z majhnim odmerkom, ki se za doseganje optimalnega učinka zdravljenja postopno povečuje glede na klinično toleranco, zato prilagajanje odmerka glede na spol, telesno maso ali starost ni potrebno.
English: The patches of 2 mg/24 h are used for the treatment of Parkinson's disease and Restless Leg Syndrome.
Slovenian: Obliži jakosti 2 mg/24 h se uporabljajo za zdravljenje Parkinsonove bolezni in sindroma nemirnih nog.
English: Do not use Neupro if:
Slovenian: Ne uporabljajte zdravila Neupro, če:
English: Neupro contains sodium metabisulphite, a sulphite that may cause allergic-type reactions including anaphylactic symptoms and life threatening or less severe asthmatic episodes in certain susceptible people.
Slovenian: Sulfit lahko povzroči alergijski tip reakcij, ki pri občutljivih ljudeh vključujejo simptome anafilaksije in življensko ogrožujoče ali manj hude epizode astme.
English: This can happen especially when you start using Neupro or when your dose is increased.
Slovenian: To se lahko zgodi zlasti na začetku zdravljenja z zdravilom Neupro ali ob povečanju odmerka.
English: There is no relevant use of Neupro in the paediatric population in Parkinson's disease.
Slovenian: Zdravilo Neupro ni primerno za uporabo pri pediatrični populaciji s Parkinsonovo boleznijo.
English: A further multinational double-blind study (SP889) was conducted in 287 patients with early or advanced stages of Parkinson's disease who had unsatisfactory early morning motor symptom control.
Slovenian: Naslednja večnacionalna dvojno slepa študija (SP889)je bila opravljena z 287 bolniki v zgodnji ali napredovali fazi Parkinsonove bolezni, ki so imeli zgodaj zjutraj nezadovoljivo kontrolo nad motoriko.