FrancophonIA/ELRC3.0 huggingface dataset:
English: The study population included 2089 (35%) patients with cardiovascular disease and 1130 (19%) patients with renal impairment with an eGFR < 60ml/min/1.73m2 at baseline.
Croatian: Ispitivana populacija uključila je 2089 (35%) bolesnika s kardiovaskularnom bolešću i 1130 (19%) bolesnika s oštećenjem funkcije bubrega uz eGFR < 60 ml/min/1,73 m2 na početku ispitivanja.
English: Adverse reactions reported in all clinical trials with the linagliptin+metformin combination or the use of the monocomponents (linagliptin or metformin) in clinical trials or from post-marketing experience are shown below according to system organ class.
Croatian: Nuspojave prijavljene u svim kliničkim ispitivanjima s kombinacijom linagliptin+metformin ili uz primjenu pojedinačnih komponenti (linagliptina ili metformina) u kliničkim ispitivanjima ili nakon stavljanja lijeka u promet navedene su u nastavku prema klasifikaciji organskih sustava.
English: A NOAEL of 78 times human exposure was derived for embryo-fetal toxicity in rabbits, and for maternal toxicity the NOAEL was 2.1 times human exposure.
Croatian: NOAEL pri 78 puta većoj izloženosti od one u ljudi, dobiven je za embriofetalnu toksičnost kod kunića, a za toksičnost majke NOAEL je bio 2,1 puta viši od izloženosti kod ljudi.
English: Placebo Linagliptin 5 mg Once
Croatian: Placebo Linagliptin 5 mg jedanput dnevno
English: Cardiac function
Croatian: Funkcija srca
English: Based on these results and in vivo drug interaction studies, linagliptin is considered unlikely to cause interactions with other P-gp substrates.
Croatian: Na osnovi ovih rezultata kao i in vivo ispitivanja interakcija lijekova, ne smatra se da linagliptin izaziva interakcije s drugim
English: Sulphonylureas:
Croatian: Sulfonilureje:
English: Jentadueto combines two antihyperglycaemic medicinal products with complementary mechanisms of action to improve glycaemic control in patients with type 2 diabetes: linagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, and metformin hydrochloride, a member of the biguanide class.
Croatian: Jentadueto kombinira dva antihiperglikemijska lijeka s komplementarnim mehanizmima djelovanja kako bi se poboljšala kontrola glikemije u bolesnika s dijabetesom tipa 2: linagliptin, inhibitor dipeptidil peptidaze 4 (DPP-4), i metforminklorid, član skupine bigvanida.
English: Multiple daily doses of linagliptin had a minimal effect on the steady-state pharmacokinetics of simvastatin, a sensitive CYP3A4 substrate, in healthy subjects.
Croatian: Višekratne dnevne doze linagliptina imale su minimalan učinak na farmakokinetiku simvastatina u stanju dinamičke ravnoteže, osjetljivog supstrata enzima CYP3A4, u zdravih ispitanika.
English: * Based on lipase elevations >3xULN observed in clinical trials # Based on Linagliptin cardiovascular and renal safety study (CARMELINA), see also below Adverse reactions reported in patients who received metformin as monotherapy and that were not observed in patients receiving Jentadueto.
Croatian: * na osnovi povišenja lipaze >3xGGN opaženih u kliničkim ispitivanjima na osnovi Ispitivanja sigurnosti primjene linagliptina za kardiovaskularni sustav i bubrege (CARMELINA), vidjeti u nastavku nuspojave prijavljene u bolesnika koji su primili metformin kao monoterapiju i koje nisu bile opažene u bolesnika koji su primili Jentadueto.
English: Linagliptin glucose-dependently increases insulin secretion and lowers glucagon secretion thus resulting in an overall improvement in the glucose homeostasis.
Croatian: Linagliptin povećava sekreciju inzulina ovisno o glukozi i snižava sekreciju glukagona, što rezultira ukupnim poboljšanjem homeostaze glukoze.
English: Studies in animals have shown excretion of both metformin and linagliptin into milk in lactating rats.
Croatian: Ispitivanja na životinjama pokazala su da se i metformin i linagliptin izlučuju u mlijeko ženki štakora u laktaciji.
English: In clinical trials, the incidence rates of hypoglycemia were comparably low in patients taking linagliptin in combination with metformin or metformin alone.
Croatian: U kliničkim ispitivanjima, stope incidencije hipoglikemije bile su usporedivo niske u bolesnika koji su uzimali linagliptin u kombinaciji s metforminom ili metformin kao monoterapiju.
English: A statistically significant greater proportion of patients with a baseline HbA1c ≥7.0% and treated with linagliptin 5 mg achieved a target HbA1c of <7% compared to placebo.
Croatian: Statistički značajno veći udio bolesnika s početnom vrijednošću HbA1c ≥ 7,0% i liječenih linagliptinom 5 mg postigli su ciljnu vrijednost HbA1c < 7% u usporedbi s placebom.
English: Boehringer Ingelheim Ellas A.E. 5th km Paiania - Markopoulo Koropi Attiki, 194 00
Croatian: 5th km Paiania - Markopoulo Koropi Attiki, 194 00
English: Abdominal pain very common
Croatian: Bol u abdomenu vrlo često
English: Maximum daily dose is 1000 mg.
Croatian: Maksimalna dnevna doza je 1000 mg.
English: Maximum daily dose is 3000 mg.
Croatian: Maksimalna dnevna doza je 3000 mg.
English: Digoxin:
Croatian: Digoksin:
English: If this happens you must stop taking Jentadueto and contact a doctor or the nearest hospital immediately, as lactic acidosis may lead to coma.
Croatian: Ako Vam se to dogodi, morate prestati uzimati lijek Jentadueto i odmah se obratiti liječniku ili otići u najbližu bolnicu, jer laktacidoza može dovesti do kome.
English: Intravascular administration of iodinated contrast agents may lead to contrast induced nephropathy, resulting in metformin accumulation and an increased risk of lactic acidosis.
Croatian: Intravaskularna primjena jodiranih kontrastnih sredstava može dovesti do nefropatije izazvane kontrastom, što dovodi do nakupljanja metformina i povećanja rizika od laktacidoze.
English: Metformin hydrochloride stimulates intracellular glycogen synthesis by acting on glycogen synthase.
Croatian: Metforminklorid potiče intracelularnu sintezu glikogena djelovanjem na glikogen sintazu.
English: Jentadueto is also available in plastic bottles with plastic screw cap and a silica gel desiccant.
Croatian: Jentadueto je također dostupan u plastičnim bocama s plastičnim zatvaračem na navoj i silikagelom kao sredstvom za sušenje.
English: Non-clinical reproduction studies did not indicate an additive teratogenic effect attributed to the coadministration of linagliptin and metformin.
Croatian: Neklinička ispitivanja utjecaja na reprodukciju nisu ukazala na dodatne teratogene učinke povezane s istovremenom primjenom linagliptina i metformina.
English: Linagliptin 5 mg once daily and 2.5 mg twice daily provided comparable (CI: -0.07; 0.19) significant HbA1c reductions of -0.80% (from baseline 7.98%), and -0.74% (from baseline 7.96%) compared to placebo.
Croatian: Linagliptin 5 mg jedanput dnevno i 2,5 mg dvaput dnevno dali su usporediva (CI: -0,07; 0,19) značajna smanjenja HbA1c od -0,80% (od početne vrijednosti 7,98%), i -0,74% (od početne vrijednosti 7,96%) u usporedbi s placebom.
English: Jentadueto should not be used during pregnancy.
Croatian: Jentadueto se ne smije primjenjivati u trudnoći.
English: The NOAEL for fertility, early embryonic development and teratogenicity in rats was set at > 900 times the human exposure.
Croatian: NOAEL za plodnost, rani razvoj embrija i teratogenost kod štakora postavljen je na doze > 900 puta više od izloženosti kod ljudi.
English: Bioequivalence studies in healthy subjects demonstrated that the Jentadueto (linagliptin/metformin hydrochloride) combination tablets are bioequivalent to co-administration of linagliptin and metformin hydrochloride as individual tablets.
Croatian: Ispitivanja bioekvivalencije na zdravim ispitanicima pokazala su da su Jentadueto (linagliptin/metforminklorid) kombinirane tablete bioekvivalentne istovremenoj primjeni linagliptina i metforminklorida u obliku odvojenih tableta.
English: Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3).
Croatian: Ispitivanja na životinjama ne ukazuju na izravan ili neizravan štetan učinak na reprodukciju (vidjeti dio 5.3).
English: No teratogenic effects were observed in rabbits at > 1,000 times human exposure.
Croatian: Nisu primijećeni teratogeni učinci u kunića pri dozama > 1000 puta višima od izloženosti kod ljudi.
English: The safety of linagliptin 2.5 mg twice daily (or its bioequivalent of 5 mg once daily) in combination with metformin has been evaluated in over 6800 patients with type 2 diabetes mellitus.
Croatian: Sigurnost linagliptina 2,5 mg dvaput dnevno (ili njegovog bioekvivalenta od 5 mg jedanput dnevno) u kombinaciji s metforminom ocjenjivana je na više od 6800 bolesnika s dijabetes melitusom tipa 2.
English: Steady-state predictions for AUC of linagliptin in patients with ESRD indicated comparable exposure to that of patients with moderate or severe renal impairment.
Croatian: Predviđanja za AUC linagliptina u stanju dinamičke ravnoteže kod bolesnika s ESRD-om (bolešću bubrega u završnoj fazi) ukazala su na usporedivu izloženost s onom kod bolesnika s umjerenim ili teškim oštećenjem bubrega.
English: • in patients already being treated with the combination of linagliptin and metformin as separate tablets.
Croatian: • u bolesnika koji se već liječe kombinacijom linagliptina i metformina u obliku zasebnih tableta.
English: The observed incidence of hypoglycaemia in patients treated with linagliptin was similar to placebo.
Croatian: Primijećena incidencija hipoglikemije kod bolesnika liječenih linagliptinom bila je slična placebu.
English: Erythema very rare
Croatian: Eritem vrlo rijetko
English: An embryofetal development study in pregnant rats did not indicate a teratogenic effect attributed to the co-administration of linagliptin and metformin at AUC exposure levels up to 4 and 30 times human exposure, respectively.
Croatian: Ispitivanje embrio-fetalnog razvoja u skotnih štakora nije ukazalo na teratogene učinke pripisane istovremenoj primjeni linagliptina i metformina pri vrijednostima AUC izloženosti do 4, odnosno 30 puta većoj od izloženosti u ljudi.
English: Pack sizes of 14, 60 and 180 film-coated tablets.
Croatian: Veličine pakiranja od 14, 60 i 180 filmom obloženih tableta.
English: When linagliptin and metformin were administered in combination with insulin, hypoglycaemia was the most frequently reported adverse event, but occurred at comparable rate when placebo and metformin were combined with insulin (linagliptin plus metformin plus insulin 29.5% and 30.9% in the placebo plus metformin plus insulin group) with a low rate of severe (requiring assistance) episodes (1.5% and 0.9%).
Croatian: Kada su se linagliptin i metformin primijenili u kombinaciji s inzulinom, hipoglikemija je bila najčešće prijavljen štetni događaj, ali se ona pojavila u usporedivoj stopi kada su se placebo i metformin kombinirali s inzulinom (linagliptin plus metformin plus inzulin 29,5% i 30,9% u skupini placebo plus metformin plus inzulin) s niskom stopom teških (koje su zahtijevale pomoć) epizoda (1,5% i 0,9%).
English: Symptoms of lactic acidosis are non-specific such as feeling or being very sick, vomiting, stomach ache with muscle cramps, a general feeling of not being well with severe tiredness, and difficulty in breathing.
Croatian: Simptomi laktacidoze su nespecifični kao što su mučnina ili jako povraćanje, bol u trbuhu uz grčeve mišića, općeniti osjećaj lošeg stanja uz težak umor i otežano disanje.
English: Change in clinical status of patients with previously controlled type 2 diabetes As Jentadueto contains metformin, a patient with previously well controlled type 2 diabetes on Jentadueto who develops laboratory abnormalities or clinical illness (especially vague and poorly defined illness) should be evaluated promptly for evidence of ketoacidosis or lactic acidosis.
Croatian: S obzirom da Jentadueto sadrži metformin, bolesnik s prethodno dobro kontroliranim dijabetesom tipa 2 na Jentaduetu koji razvije laboratorijske abnormalnosti ili kliničku bolest (naročito nejasno i loše definiranu bolest), mora se hitno ocijeniti u pogledu dokaza ketoacidoze ili laktacidoze.
English: The pharmacokinetics of linagliptin was generally similar in healthy subjects and in patients with type 2 diabetes.
Croatian: Farmakokinetika linagliptina bila je općenito slična kod zdravih osoba i kod bolesnika s dijabetesom tipa 2.
English: Therapy may be restarted no earlier than 48 hours following surgery or resumption of oral nutrition and provided that renal function has been re-evaluated and found to be stable.
Croatian: S terapijom se smije ponovno započeti tek nakon što je od kirurškog zahvata ili ponovne uspostave peroralne prehrane prošlo najmanje 48 sati i pod uvjetom da je funkcija bubrega bila ponovno procijenjena i da je potvrđeno da je stabilna.
English: After once daily dosing of 5 mg linagliptin, steady-state plasma concentrations are reached by the third dose.
Croatian: Nakon jednokratnog dnevnog doziranja 5 mg linagliptina stanje dinamičke ravnoteže koncentracije u plazmi se postiže trećom dozom.
English: Some patients have experienced the following side effects while taking Jentadueto with insulin - Uncommon: liver function disorders, constipation
Croatian: Neki bolesnici su imali sljedeće nuspojave tijekom uzimanja Jentadueta s inzulinom - Manje često: poremećaji jetrene funkcije, zatvor
English: Hazard Ratio
Croatian: Omjer hazarda
English: It is not known whether linagliptin passes into human milk.
Croatian: Nije poznato prolazi li linagliptin u majčino mlijeko.
English: When renal function is impaired, renal clearance is decreased in proportion to that of creatinine and thus the elimination half-life is prolonged, leading to increased levels of metformin hydrochloride in plasma.
Croatian: Kada je bubrežna funkcija oštećena, bubrežni klirens je smanjen proporcionalno klirensu kreatinina i stoga je poluvijek eliminacije produljen, dovodeći do povišenih razina metforminklorida u plazmi.
English: In placebocontrolled studies, more than 1800 patients were treated with the therapeutic dose of either 2.5 mg linagliptin twice daily (or its bioequivalent of 5 mg linagliptin once daily) in combination with metformin for ≥ 12/24 weeks.
Croatian: U placebom kontroliranim ispitivanjima više od 1800 bolesnika bilo je liječeno terapijskom dozom od 2,5 mg linagliptina dvaput dnevno (ili njegovim bioekvivalentom od 5 mg linagliptina jedanput dnevno) u kombinaciji s metforminom u trajanju ≥ 12/24 tjedna.
English: In vitro assessment of interactions
Croatian: Procjena interakcija lijeka in vitro
English: When linagliptin and metformin were administered in combination with a sulphonylurea, hypoglycaemia was the most frequently reported adverse event (linagliptin plus metformin plus sulphonylurea 23.9% and 16.0% in placebo plus metformin plus sulphonylurea).
Croatian: Kada su se linaglitptin i metformin primijenili u kombinaciji sa sulfonilurejom, hipoglikemija je bila najčešće prijavljen štetni događaj (linagliptin plus metformin plus sulfonilureja 23,9% i 16,0% u skupini placebo plus metformin plus sulfonilureja).
English: Hypoglycaemia is not identified as adverse reaction for linagliptin, metformin, or linagliptin plus metformin.
Croatian: Hipoglikemija nije utvrđena kao nuspojava linagliptina, metformina ili kombinacije linagliptin plus metformin.
English: Liver, kidneys, stomach, reproductive organs, thymus, spleen, and lymph nodes were target organs of toxicity in Cynomolgus monkeys at more than 450 times human exposure.
Croatian: Jetra, bubrezi, želudac, reproduktivni organi, timus, slezena i limfni čvorovi bili su ciljni organi toksičnosti kod cynomolgus majmuna pri dozama 450 puta višima nego kod izloženosti u ljudi.
English: 90 x 1 film-coated tablets.
Croatian: 60 x 1 filmom obložena tableta.
English: When linagliptin plus metformin hydrochloride is used in combination with insulin, a lower dose of insulin may be required to reduce the risk of hypoglycaemia (see section 4.4).
Croatian: Kada se kombinacija linagliptin plus metforminklorid primjenjuje zajedno s inzulinom, može biti potrebna niža doza inzulina radi smanjenja rizika od hipoglikemije (vidjeti dio 4.4).
English: Animal studies with metformin do not indicate harmful effects with respect to reproductive toxicity (see section 5.3).
Croatian: Ispitivanja metformina na životinjama ne ukazuju na štetne učinke na reprodukciju (vidjeti dio 5.3).
English: Linagliptin as add-on to a combination of metformin and sulphonylurea therapy A placebo-controlled study of 24 weeks in duration was conducted to evaluate the efficacy and safety of linagliptin 5 mg to placebo, in patients not sufficiently treated with a combination with metformin and a sulphonylurea.
Croatian: Linagliptin kao dodatak kombiniranom liječenju metforminom i sulfonilurejom Provedeno je placebom kontrolirano ispitivanje u trajanju od 24 tjedna u svrhu ocjene djelotvornosti i sigurnosti linagliptina od 5 mg, u odnosu na placebo, kod bolesnika koji nisu dostatno liječeni kombinacijom metformina i sulfonilureje.
English: When linagliptin was added to a sulphonylurea on a background of metformin, the incidence of hypoglycaemia was increased over that of placebo.
Croatian: Kada se na osnovno liječenje metforminom dodao linagliptin uz sulfonilureju, povećala se incidencija hipoglikemije u odnosu na placebo.
English: When linagliptin plus metformin hydrochloride is used in combination with a sulphonylurea, a lower dose of the sulphonylurea may be required to reduce the risk of hypoglycaemia (see section 4.4).
Croatian: Kada se linagliptin plus metforminklorid primjenjuje u kombinaciji sa sulfonilurejom, može se razmotriti niža doza sulfonilureje kako bi se smanjio rizik od hipoglikemije (vidjeti dio 4.4).
English: PHARMACEUTICAL FORM AND CONTENTS Multipack comprising 2 packs, each containing 60 x 1 film-coated tablets Multipack comprising 2 packs, each containing 90 x 1 film-coated tablets Multipack comprising 2 packs, each containing 100 x 1 film-coated tablets
Croatian: Višestruko pakiranje koje sadrži 2 pakiranja, svako sa 60 x 1 filmom obloženom tabletom Višestruko pakiranje koje sadrži 2 pakiranja, svako sa 90 x 1 filmom obloženom tabletom Višestruko pakiranje koje sadrži 2 pakiranja, svako sa 100 x 1 filmom obloženom tabletom
English: Linagliptin trough concentrations were also measured in elderly (age ≥ 70 years) with type 2 diabetes in a phase III study of 24 weeks duration.
Croatian: Koncentracije linagliptina na kraju dozirnog intervala bile su također mjerene na starijim osobama (dob ≥ 70 godina) s dijabetesom tipa 2 u fazi III ispitivanja u trajanju 24 tjedna.
English: In the pooled analysis of the seven placebo-controlled trials, the overall incidence of adverse events in patients treated with placebo and metformin was comparable to that seen with linagliptin 2.5 mg and metformin (54.3 and 49.0%).
Croatian: U združenoj analizi sedam placebom kontroliranih ispitivanja, ukupna incidencija štetnih događaja u bolesnika liječenih placebom i metforminom bila je slična skupini na linagliptinu 2,5 mg i metforminu (54,3% i 49,0%).
English: Number of patients Primary CV composite (Cardiovascular death, non-fatal MI, non-fatal stroke)
Croatian: Broj bolesnika Primarna KV kompozitna mjera (kardiovaskularna smrt, MI bez smrtnog ishoda, moždani udar bez smrtnog ishoda) Mortalitet zbog svih uzroka
English: When Jentadueto is used with a sulphonylurea medicine or with insulin, low blood sugar can occur and your doctor may reduce the dose of your sulphonylurea or insulin.
Croatian: Kada se Jentadueto primjenjuje sa sulfonilurejom ili inzulinom može doći do niskih vrijednosti šećera u krvi te Vam liječnik može sniziti dozu sulfonilureje ili inzulina.
English: Use of DPP-4 inhibitors has been associated with a risk of developing acute pancreatitis.
Croatian: Upotreba Jentadueta povezana je s rizikom od razvoja akutnog pankreatitisa.
English: Bottle: Keep the bottle tightly closed in order to protect from moisture.
Croatian: Boca: Bocu čuvati čvrsto zatvorenu radi zaštite od vlage.
English: Renal clearance at steady-state was approximately 70 ml/min.
Croatian: Bubrežni klirens je pri stanju dinamičke ravnoteže bio oko 70 ml/min.
English: Investigations Amylase increased uncommon
Croatian: Pretrage Povišena amilaza manje često
English: Metformin is excreted in human milk in small amounts.
Croatian: Metformin se izlučuje u majčino mlijeko u ljudi u malim količinama.
English: Lactic acidosis is characterised by acidotic dyspnea, abdominal pain, muscle cramps, asthenia and hypothermia followed by coma.
Croatian: Značajke laktacidoze su acidozna dispneja, bol u abdomenu, grčevi u mišićima, astenija i hipotermija nakon koje slijedi koma.
English: Caution should be exercised in patients with a history of pancreatitis.
Croatian: Potreban je oprez u bolesnika s pankreatitisom u anamnezi.
English: Linagliptin cardiovascular safety study (CAROLINA) CAROLINA was a randomized study in 6033 patients with early type 2 diabetes and increased CV risk or established complications who were treated with linagliptin 5 mg (3023) or glimepiride 1-4mg (3010) added to standard of care (including background therapy with metformin in 83% of patients) targeting regional standards for HbA1c and CV risk factors.
Croatian: Ispitivanje kardiovaskularne sigurnosti primjene linagliptina (CAROLINA) CAROLINA je bila randomizirano ispitivanje u 6033 bolesnika s ranim dijabetesom tipa 2 i povećanim kardiovaskularnim rizikom ili utvrđenim komplikacijama koji su bili liječeni linagliptinom 5 mg (3023) ili glimepiridom 1 - 4 mg (3010) dodanim uz standardno liječenje (uključujući osnovnu terapiju metforminom u 83% bolesnika) s ciljem postizanja regionalnih standarda za HbA1c i kardiovaskularne faktore rizika.
English: The efficacy and safety of linagliptin 2.5 mg twice daily versus 5 mg once daily in combination with metformin in patients with insufficient glycaemic control on metformin monotherapy was evaluated in a double-blind placebo-controlled study of 12 weeks duration.
Croatian: Djelotvornost i sigurnost linagliptina 2,5 mg dvaput dnevno naspram 5 mg jedanput dnevno u kombinaciji s metforminom u bolesnika s nedostatnom kontrolom glikemije na monoterapiji metforminom bila je ocijenjena u dvostruko slijepom placebom kontroliranom ispitivanju u trajanju od 12 tjedana.
English: The dose of Jentadueto should provide linagliptin dosed as 2.5 mg twice daily (5 mg total daily dose) and a dose of metformin similar to the dose already being taken.
Croatian: Doza Jentadueta mora osigurati linagliptin u dozi od 2,5 mg dvaput dnevno (ukupna dnevna doza 5 mg) i dozu metformina sličnu dozi koja se već uzima.
English: In rats, effects on reproductive organs, thyroid and the lymphoid organs were seen at more than 1500 times human exposure.
Croatian: Kod štakora, učinci na reproduktivne organe, štitnjaču i limfoidne organe primijećeni su pri dozama preko 1500 puta višima nego kod izloženosti u ljudi.
English: The steady-state pharmacokinetics of 5 mg linagliptin were not changed by concomitant administration of a single 1.75 mg dose glibenclamide (glyburide).
Croatian: Farmakokinetika 5 mg linagliptina u stanju dinamičke ravnoteže nije se promijenila uslijed istodobne primjene jednokratne doze od 1,75 mg glibenklamida (gliburid).
English: Adverse reactions reported in patients who received linagliptin+metformin alone (as mono-components or in combination) or as add-on to other anti-diabetic therapies in clinical trial and from post-marketing experience
Croatian: Tablica 2: Nuspojave prijavljene u bolesnika koji su primali linagliptin+metformin kao monoterapiju (kao pojedinačne komponente ili u kombinaciji) ili kao dodatnu terapiju uz druge antidijabetičke terapije u kliničkim ispitivanjima te iz iskustva nakon stavljanja lijeka u promet
English: • Inhibitors of OCT1 (such as verapamil) may reduce efficacy of metformin.
Croatian: • inhibitorima OCT1 (kao što je verapamil) može smanjiti djelotvornost metformina.
English: Linagliptin is a P-glycoprotein substrate, and inhibits P-glycoprotein mediated transport of digoxin with low potency.
Croatian: Linagliptin je P-glikoproteinski supstrat koji s niskom potentnošću inhibira prijenos digoksina posredovan P-glikoproteinom.