FrancophonIA/ELRC3.0 huggingface dataset:
English: AZOPT is a carbonic anhydrase inhibitor and, although administered topically, is absorbed systemically.
Croatian: AZOPT je inhibitor karboanhidraze i premda se primjenjuje lokalno, apsorbira se sistemski.
English: Nasolacrimal occlusion or gently closing the eyelid after instillation is recommended.
Croatian: Nakon ukapavanja preporučuje se nazolakrimalna okluzija ili lagano zatvaranje vjeđa.
English: AZOPT is a sulphonamide inhibitor of carbonic anhydrase and, although administered topically, is absorbed systemically.
Croatian: AZOPT je sulfonamidni inhibitor karboanhidraze i premda se primjenjuje lokalno, apsorbira se sistemski.
English: Each millilitre contains 10 mg of brinzolamide.
Croatian: Svaki mililitar sadrži 10 mg/ml brinzolamida.
English: Uncommon: back pain, muscle spasms, myalgia Not Known: arthralgia, pain in extremity
Croatian: Manje često: bol u leđima, spazam mišića, mijalgija Nepoznato: artralgija, bol u ekstremitetima
English: This metabolite binds mainly to CA-I in the presence of brinzolamide.
Croatian: U prisutnosti brinzolamida ovaj metabolit se uglavnom veže na CA-I.
English: A MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Croatian: PROIZVOĐAČ(I) ODGOVORAN(ODGOVORNI) ZA PUŠTANJE SERIJE LIJEKA U PROMET
English: The same type of adverse reactions that are attributable to oral carbonic anhydrase inhibitors may occur with topical administration.
Croatian: Iste vrste nuspojava koje su vezane uz peroralnu primjenu inhibitora karboanhidraze mogu se javiti i pri lokalnoj primjeni.
English: Currently available data are described in sections 4.8 and 5.1.
Croatian: Trenutno dostupni podaci opisani su u dijelovima 4.8 i 5.1. AZOPT se ne preporučuje za primjenu u dojenčadi, djece i adolescenata.
English: • Put the bottle cap back on firmly immediately after use
Croatian: • Bočicu dobro zatvorite zatvaračem odmah nakon primjene.
English: AZOPT was primarily evaluated in concomitant administration with timolol during adjunctive glaucoma therapy.
Croatian: AZOPT je primarno evaluiran u kombiniranoj terapiji glaukoma uz istodobno primjenjivan timolol.
English: In humans, the metabolite N-desethylbrinzolamide is formed, which also binds to CA and accumulates in RBCs.
Croatian: N-desetil-brinzolamid, koji se veže na CA i akumulira u eritrocitima.
English: - Effects in the eye: sensitivity to light, inflammation or infection of the conjunctiva, eye swelling, eyelid itching, redness or swelling, deposits in eye, glare, burning sensation, growth on surface of eye, increased pigmentation of the eye, tired eyes, eyelid crusting, or increased tear production.
Croatian: - Nuspojave na oku: osjetljivost na svjetlo, upala ili infekcija spojnice, oticanje oka, svrbež vjeđa, crvenilo ili oticanje, naslage u oku, blještanje pred očima, osjećaj pečenja, naslage na površini oka, pojačana pigmentacija oka, umorne oči, krustanje vjeđa ili pojačano stvaranje suza.
English: Rare: angina pectoris, heart rate irregular Not Known: arrhythmia, tachycardia, hypertension, blood pressure increased, blood pressure decreased, heart rate increased
Croatian: Nepoznato: aritmija, tahikardija, hipertenzija, povišeni krvni tlak, sniženi krvni tlak, povišena srčana frekvencija
English: The IOP-reducing effect of AZOPT as adjunctive therapy to the prostaglandin analogue travoprost was studied.
Croatian: Ispitivan je učinak AZOPTA na snižavanje IOT-a kao dodatne terapije analogu prostaglandina travoprostu.
English: Carbonic anhydrase (CA) is an enzyme found in many tissues of the body, including the eye. Carbonic anhydrase catalyses the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid.
Croatian: Karboanhidraza katalizira reverzibilnu reakciju koja obuhvaća i hidraciju ugljičnog dioksida i dehidraciju ugljične kiseline.
English: Rare: tinnitus Not Known: vertigo
Croatian: Rijetko: tinitus Nepoznato: vrtoglavica
English: Careful monitoring of patients with compromised corneas such as patients with diabetes mellitus or corneal dystrophies is recommended.
Croatian: Kod bolesnika s oštećenjem rožnice, npr. kod bolesnika s diabetes mellitusom ili distrofijom rožnice, preporučuje se pažljivo praćenje.
English: Discard four weeks after first opening.
Croatian: Odbaciti 4 tjedna nakon prvog otvaranja.
English: Additionally the IOP-reducing effect of AZOPT as adjunctive therapy to the prostaglandin analogue travoprost has been studied.
Croatian: Dodatno je ispitivan utjecaj AZOPTA na snižavanje IOT-a kao dodatne terapije s analogom prostanglandina travoprostom.
English: Uncommon: pain, chest discomfort, fatigue, feeling abnormal Rare: chest pain, feeling jittery, asthenia, irritability Not Known: peripheral oedema, malaise
Croatian: Manje često: bol, nelagoda u prsištu, umor, neuobičajen osjećaj, Rijetko: bol u prsištu, osjećaj treme, astenija, razdražljivost Nepoznato: periferni edem, malaksalost
English: Metabolism and nutrition disorders Not known: decreased appetite Psychiatric disorders
Croatian: Poremećaji imunološkog sustava Nepoznato: preosjetljivost Poremećaji metabolizma i prehrane
English: - General side effects: increased allergic symptoms, decreased sensation, tremor, loss or decrease in taste, decreased blood pressure, increased blood pressure, increased heart rate, joint pain, asthma, pain in extremity, skin redness, inflammation, or itching, abnormal liver blood tests, swelling of the extremities, frequent urination, decreased appetite, feeling unwell.
Croatian: Opće nuspojave: pojačani simptomi alergije, smanjena osjetljivost, nevoljno drhtanje, gubitak ili smanjena osjetljivost okusa, sniženi krvni tlak, povišeni krvni tlak, povećana brzina srčanih otkucaja, bol u zglobovima, astma, bol u ekstremitetima, crvenilo kože, upala, ili svrbež, abnormalan nalaz krvnih pretraga funkcije jetre, oticanje ekstremiteta, učestalo mokrenje, smanjeni apetit, opće loše osjećanje.
English: - Effects in the eye: eyelid abnormality, visual disturbance, corneal disorder, eye allergy, decreased growth or number of eyelashes, eyelid redness.
Croatian: - Nuspojave na oku: poremećaj vjeđa, smetnje vida, poremećaj rožnice, alergija oka, smanjen rast ili broj trepavica, crvenilo vjeđa.
English: Common: blurred vision, eye irritation, eye pain, foreign body sensation in eyes, ocular hyperaemia Uncommon: corneal erosion, keratitis, punctate keratitis, keratopathy, deposit eye, corneal staining, corneal epithelium defect, corneal epithelium disorder, blepharitis, eye pruritus, conjunctivitis, eye swelling, meibomianitis, glare, photophobiadry eye, allergic conjunctivitis, pterygium, scleral pigmentation, asthenopia, ocular discomfort, abnormal sensation in eye, keratoconjunctivitis sicca, subconjunctival cyst, conjunctival hyperaemia, eyelids pruritus, eye discharge, eyelid margin crusting, lacrimation increased Rare: corneal oedema, diplopia, visual acuity reduced, photopsia, hypoaesthesia eye, periorbital oedema, intraocular pressure increased, optic nerve cup/disc ratio increased Not Known: corneal disorder, visual disturbance, eye allergy, madarosis, eyelid disorder, erythema of eyelid
Croatian: Manje često: erozija rožnice, keratitis, punktiformni keratitis, keratopatija, depoziti u oku, obojenje rožnice, defekt epitela rožnice, poremećaj epitela rožnice, blefaritis, svrbež oka, konjunktivitis, oticanje oka, meibomianitisa, blještavilo pred očima, fotofobija, suho oko, alergijski konjunktivitis, pterigij, skleralna pigmentacija, astenopija, nelagodan osjećaj u oku, neuobičajen osjećaj u oku, keratokonjunktivitis sicca, subkonjunktivalna cista, konjunktivalna hiperemija, svrbež vjeđa, iscjedak iz oka, krustanje rubova vjeđa, pojačano suzenje Rijetko: edem rožnice, diplopija, smanjena oštrina vida, fotopsija, hipoestezija oka, periorbitalni edem, povišeni intraokularni tlak, povećanje omjera jamice/diska glave vidnog živca.
English: - General side effects: decreased or reduced heart function, a forceful heartbeat that may be rapid or irregular, decreased heart rate, difficulty breathing, shortness of breath, cough, decreased red blood cell count in blood, increased chlorine level in blood, dizziness, difficulty with memory, depression, nervousness, decreased emotional interest, nightmare, generalized weakness, fatigue, feeling abnormal, pain, movement problems, decreased sex drive, male sexual difficulty, cold symptoms, chest congestion, sinus infection, throat irritation, throat pain, abnormal or decreased sensation in mouth, inflammation of the lining of the oesophagus, abdominal pain, nausea, vomiting, upset stomach, frequent bowel movements, diarrhoea, intestinal gas, digestive disorder, kidney pain, muscle pain, muscle spasms, back pain, nose bleeds, runny nose, stuffy nose, sneezing, rash, abnormal skin sensation, itching, smooth skin rash or redness covered by elevated bumps, skin tightness, headache, dry mouth, debris in eye.
Croatian: Opće nuspojave: smanjena srčana funkcija, snažni ubrzani ili nepravilni otkucaji srca, smanjen puls, otežano disanje, nedostatak zraka, kašalj, smanjenje broja crvenih krvnih stanica u krvi, povećanje razine klorida u krvi, omaglica, poteškoće s pamćenjem, depresija, nervoza, bezvoljnost, noćne more, opća slabost, umor, neuobičajen osjećaj, bol, problemi sa kretanjem, smanjeni spolni nagon, spolna disfunkcija kod muškaraca, simptomi prehlade, kongestija u prsnom košu, upala sinusa, iritacija grla, bolu grlu, neuobičajena ili smanjena osjetljivost u ustima, upala sluznice jednjaka, bol u trbuhu, mučnina, povraćanje, nadražen želudac, učestalo pražnjenje crijeva, proljev, plinovi u crijevima, probavni poremećaj, bol u bubrezima, bol u mišićima, grčevi u mišićima, bol u leđima, krvarenje iz nosa, curenje iz nosa, začepljenost nosa, kihanje, osip, neuobičajen osjećaj na koži, svrbež, plitki osip ili crvenilo s izbočinama, zatezanje kože, glavobolja, suha usta, strano tijelo u oku.
English: Association between AZOPT and miotics or adrenergic agonists has not been evaluated during adjunctive glaucoma therapy.
Croatian: Tijekom dodatne terapije glaukoma AZOPT kapima i mioticima ili adrenergičkim agonistima nije praćeno njihovo međusobno djelovanje.
English: - General side effects: memory impairment, drowsiness, chest pain, upper respiratory tract congestion, sinus congestion, nasal congestion, dry nose, ringing in ears, hair loss, generalized itching, feeling jittery, irritability, irregular heart rate, body weakness, difficulty sleeping, wheezing, itchy skin rash.
Croatian: Opće nuspojave: slabljenje pamćenja, omamljenost, bol u prsnom košu, oticanje gornjih dišnih puteva, začepljenje sinusa, začepljenje nosa, suhoća nosa, zvonjava u ušima, gubitak dlaka, opći svrbež, osjećaj nervoze, razdražljivost, nepravilan puls, slabost tijela, poteškoće sa spavanjem, piskanje, osip kože praćen svrbežom.
English: Uncommon: oesophagitis, diarrhoea, nausea, vomiting, dyspepsia, upper abdominal pain, abdominal discomfort, stomach discomfort, flatulence, frequent bowel movements, gastrointestinal disorder, hypoaesthesia oral, paraesthesia oral, dry mouth
Croatian: Poremećaji probavnog sustava Često: disgeuzija Manje često: ezofagitis, dijareja, mučnina, povraćanje, dispepsija, bol u gornjem dijelu abdomena, nelagoda u abdomenu, nelagoda u želucu, flatulencija, učestalo pražnjenje crijeva, gastrointestinalni poremećaj, oralna hipoestezija, oralna parestezija, suha usta
English: Uncommon: cardio-respiratory distress, bradycardia, palpitations
Croatian: Manje često: kardio-respiratorni distres, bradikardija, palpitacije Rijetko: angina pektoris, nepravilna srčana frekvencija
English: Brinzolamide RBC concentration ranged from about 20 to 40 µM by week 4 of treatment.
Croatian: Do 4. tjedna liječenja koncentracije brinzolamida u eritrocitima bile su između 20 i 40 M.
English: • Bring the bottle tip close to the eye. Use the mirror if it helps
Croatian: • Vrh bočice približite oku.
English: CLINICAL PARTICULARS
Croatian: Psihijatrijski poremećaji
English: - Effects in the eye: blurred vision, eye irritation, eye pain, eye discharge, itchy eye, dry eye, abnormal eye sensation, redness of the eye.
Croatian: - Nuspojave na oku: zamagljen vid, iritacija oka, bol u oku, iscjedak iz oka, svrbež oka, suho oko, neuobičajen osjećaj u oku, crvenilo oka.
English: • Shake the bottle and twist off the cap. After the cap is removed, if the tamper evident snap collar is loose, remove before using product.
Croatian: Nakon skidanja zatvarača, ukoliko je zaštitni obruč s evidencijom otvaranja klimav, uklonite ga prije primjene lijeka.
English: Posology
Croatian: Proizvođač
English: Uncommon: dyspnoea, epistaxis, oropharyngeal pain, pharyngolaryngeal pain, throat irritation, upper airway cough syndrome, rhinorrhoea, sneezing Rare: bronchial hyperreactivity, upper respiratory tract congestion, sinus congestion, nasal congestion, cough, nasal dryness
Croatian: Manje često: dispneja, epistaksa, orofaringealna bol, faringolaringealna bol, iritacija grla, postnazalni drip, rinoreja, kihanje
English: Uncommon: rash, rash maculo-papular, skin tightness Rare: urticaria, alopecia, pruritus generalised Not Known: dermatitis, erythema
Croatian: Nepoznato: abnormalne vrijednosti testova jetrene funkcije Poremećaj kože i potkožnog tkiva Manje često: osip, makulopapularni osip, zategnutost kože Rijetko: urtikarija, alopecija, generalizirani svrbež
English: Further information on Grastofil can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Croatian: Više informacija o lijeku Grastofil možete naći na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: Severe neutropenia lasted on average for 1.4 days which compared with 1.6 days and 1.8 days reported in studies using filgrastim found in the literature.
Croatian: Teška neutropenija trajala je u prosjeku 1,4 dana, u usporedbi s 1,6 dana i 1,8 dana prijavljenih u ispitivanjima s filgrastima dostupnima u literaturi.
English: Patients were given the chemotherapy on day 1 of a three-week cycle, and then received one dose of Grastofil the next day and daily for up to 14 days.
Croatian: Bolesnice su primile kemoterapiju prvog dana trotjednog ciklusa, a zatim su primile jednu dozu lijeka Grastofil sljedećeg dana i svakodnevno po jednu dozu tijekom 14 dana.
English: What measures are being taken to ensure the safe and effective use of Grastofil?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Grastofil?
English: This means that Grastofil is highly similar to another biological medicine (the ‘reference medicine') that is already authorised in the EU.
Croatian: Drugim riječima, Grastofil je vrlo sličan drugom biološkom lijeku („referentni lijek”) koji je već odobren u EU-u.
English: An overview of Grastofil and why it is authorised in the EU
Croatian: Pregled informacija o lijeku Grastofil i zašto je odobren u EU-u
English: Other information about Grastofil
Croatian: Ostale informacije o lijeku Grastofil
English: Other side effects may be seen in more than 1 patient in 10, depending on the condition that Grastofil is being used for.
Croatian: Druge nuspojave mogu se javiti u više od 1 na 10 bolesnika, ovisno o stanju za koje se Grastofil primjenjuje.
English: Grastofil received a marketing authorisation valid throughout the EU on 18 October 2013.
Croatian: Lijek Grastofil dobio je odobrenje za stavljanje u promet koje vrijedi na prostoru EU-a od 18. listopada
English: The way Grastofil is given, its dose and the duration of treatment depend on why it is being used, the patient's body weight and the response to treatment.
Croatian: Način primjene lijeka Grastofil, njegovo doziranje i trajanje liječenja ovise o svrsi primjene, tjelesnoj težini bolesnika i odgovoru na liječenje.
English: Grastofil was studied in one main study involving 120 female adult patients with breast cancer treated with chemotherapy (medicines to treat cancer) known to cause neutropenia.
Croatian: Grastofil je ispitan u jednom glavnom ispitivanju koje je obuhvaćalo 120 odraslih žena oboljelih od raka dojke i liječenih kemoterapijom (lijekovi za liječenje raka) za koju je poznato da uzrokuje neutropeniju.
English: Grastofil is a ‘biosimilar medicine'.
Croatian: Grastofil je „biosličan lijek”.
English: Grastofil can only be obtained with a prescription and treatment should be given in collaboration with a centre for cancer treatment.
Croatian: Grastofil se izdaje samo na liječnički recept, a liječenje se mora primjenjivati u suradnji s centrom za liječenje raka.
English: Data from published studies indicate that the benefits and safety of filgrastim are similar in both adults and children receiving chemotherapy.
Croatian: Podatci iz objavljenih ispitivanja upućuju na to da su koristi i sigurnost filgrastima slične u odraslih i u djece koja primaju kemoterapiju.
English: What is Grastofil and what is it used for?
Croatian: Što je Grastofil i za što se primjenjuje?
English: The European Medicines Agency decided that, in accordance with EU requirements for biosimilar medicines, Grastofil has been shown to have a comparable quality, safety and effectiveness to Neupogen.
Croatian: Europska agencija za lijekove zaključila je kako je, u skladu sa zahtjevima EU-a za bioslične lijekove, lijek Grastofil dokazao kakvoću, sigurnost i učinkovitost usporedivu s lijekom Neupogen.
English: Filgrastim works in the same way as naturally produced G-CSF by encouraging the bone marrow to produce more white blood cells.
Croatian: Filgrastim djeluje na isti način kao i prirodno stvoren GCSF tako što potiče koštanu srž na stvaranje većeg broja bijelih krvnih stanica.
English: Grastofil is a medicine that stimulates the production of white blood cells and is used:
Croatian: Grastofil je lijek koji potiče stvaranje bijelih krvnih stanica, a primjenjuje se:
English: The active substance in Grastofil, filgrastim, is very similar to a human protein called granulocyte colony stimulating factor (G-CSF).
Croatian: Djelatna tvar u lijeku Grastofil, filgrastim, vrlo je slična ljudskom proteinu koji se zove čimbenik poticanja rasta granulocitnih kolonija (G-CSF).
English: Side effects reported with Grastofil are carefully evaluated and any necessary action taken to protect patients.
Croatian: Nuspojave prijavljene za lijek Grastofil pažljivo se procjenjuju i poduzimaju se potrebne mjere za zaštitu bolesnika.
English: The most common side effects with Grastofil (which may affect more than 1 in 10 people) are fever, musculoskeletal pain (pain in the muscles and bones), anaemia (low red blood cell counts), vomiting and nausea (feeling sick).
Croatian: Najčešće nuspojave lijeka Grastofil (koje se mogu javiti u više od 1 na 10 osoba) jesu vrućica, mišićnokoštana bol (bol u mišićima i kostima), anemija (nizak broj crvenih krvnih stanica), povraćanje i mučnina (osjećaj slabosti).
English: For more information about using Grastofil, see the package leaflet or contact your doctor or pharmacist.
Croatian: Za više informacija o primjeni lijeka Grastofil pogledajte uputu o lijeku ili se obratite liječniku ili ljekarniku.
English: What are the risks associated with Grastofil?
Croatian: Koji su rizici povezani s lijekom Grastofil?
English: Neutropenia is a common side effect of cancer treatment and can leave patients vulnerable to infections;
Croatian: Neutropenija je česta nuspojava liječenja raka i može učiniti bolesnike osjetljivima na infekcije;
English: As for all medicines, data on the use of Grastofil are continuously monitored.
Croatian: Kao i za sve lijekove, podatci o primjeni lijeka Grastofil kontinuirano se prate.
English: • to treat persistent neutropenia in patients with advanced human-immunodeficiency-virus (HIV) infection, to reduce the risk of bacterial infections when other treatments are not appropriate.
Croatian: • za liječenje perzistentne neutropenije u bolesnika s uznapredovalom infekcijom virusom humane imunodeficijencije (HIV) u svrhu smanjenja rizika od bakterijskih infekcija kad drugi načini liječenja nisu prikladni.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Grastofil have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Grastofil nalaze se u sažetku opisa svojstava lijeka i u uputi o lijeku.
English: Studies were also carried out to show that Grastofil produces levels of the active substance in the body that are comparable to the reference medicine, Neupogen.
Croatian: Ispitivanja su također provedena kako bi se dokazalo da Grastofil stvara razine djelatne tvari u tijelu koje su usporedive s referentnim lijekom Neupogen.
English: The medicine is available in prefilled syringes and is given by injection under the skin or infusion (drip) into a vein.
Croatian: Lijek je dostupan u napunjenim štrcaljkama, a primjenjuje se supkutanom injekcijom ili infuzijom u venu.
English: The reference medicine for Grastofil is Neupogen.
Croatian: Referentni lijek za Grastofil je Neupogen.
English: Why is Grastofil approved?
Croatian: Zašto je lijek Grastofil odobren?
English: How does Grastofil work?
Croatian: Kako djeluje Grastofil?
English: What benefits of Grastofil have been shown in studies?
Croatian: Koje su koristi od lijeka Grastofil utvrđene u ispitivanjima?
English: Therefore, the Agency's view was that, as for Neupogen, the benefits of Grastofil are greater than its risks and it can be authorised for use in the EU.
Croatian: Stoga je stav Agencije da koristi kod lijeka Grastofil, kao i kod lijeka Neupogen, nadmašuju rizike te da lijek može biti odobren za primjenu u EU-u.
English: • to help release cells from the bone marrow in patients who are about to donate blood stem cells for transplant;
Croatian: • kao pomoć za otpuštanje stanica iz koštane srži bolesnika koji će donirati matične stanice za transplantaciju;
English: For the full list of side effects and restrictions with Grastofil, see the package leaflet.
Croatian: Potpuni popis nuspojava i ograničenja pri primjeni lijeka Grastofil potražite u uputi o lijeku.
English: How is Grastofil used?
Croatian: Kako se Grastofil primjenjuje?
English: Cattle: subcutaneous or intravenous use Pigs: intramuscular use Horses: intravenous use
Croatian: Goveda: supkutana ili intravenska Svinje:
English: Pigs: intramuscular use Horses: intravenous use
Croatian: Svinje: intramuskularna Konje:
English: Meat and offal: 15 days (Cattle), Milk: 5 days
Croatian: 1 bočica Meso i jestive iznutrice: 15 dana (Goveda), Meso i jestive iznutrice: 5 dana (Svinje)
English: HDPE bottle polypropylene measuring syringe
Croatian: Rheumocam 330 mg Granule u vrećici.
English: (Cattle), Meat and offal: 5 days.
Croatian: Meso i jestive intravenska iznutrice: 5 dana
English: (Horses) Meat and offal: 5 days (Pigs)
Croatian: 1 bočica Meso i jestive iznutrice: 15 dana (Goveda), Meso i jestive iznutrice offal: 5 dana (Svinje)
English: Previously known as Anoro.
Croatian: Prethodno poznat kao Anoro.
English: Further information on Anoro Ellipta can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Croatian: Više informacija o lijeku Anoro Ellipta možete naći na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: To investigate this further the Agency recommended that a study be carried out.
Croatian: Agencija je preporučila provedbu ispitivanja kako bi se to dalje istraživalo.
English: In all 5 studies, involving over 5,600 patients, the main measure of effectiveness was based on changes in the patients' forced expiratory volumes (FEV1, the maximum volume of air a person can breathe out in one second).
Croatian: U svih pet ispitivanja, koja su uključivala 5 600 bolesnika, glavna mjera učinkovitosti lijeka temeljila se na promjenama forsiranog izdisajnog volumena bolesnika (FEV1, maksimalnog volumena zraka koji osoba može izdahnuti u prvoj sekundi).