FrancophonIA/ELRC3.0 huggingface dataset:
English: In a study of children with Sickle Cell Disease, liquid and capsule formulations resulted in similar area under the curve, peak concentrations, and half-life.
Croatian: U ispitivanju djece s bolešću srpastih stanica, formulacije lijeka u obliku tekućine i kapsula rezultirale su sličnim područjem ispod krivulje, vršnom koncentracijom i poluvijekom.
English: Cutaneous vasculitic toxicities
Croatian: Kožna vaskulitična toksičnost
English: It comes in glass bottles of 150 ml capped with a child-resistant closure.
Croatian: Isporučuje se u staklenim bočicama od 150 ml sa zatvaračem sigurnim za djecu.
English: Immediate treatment consists of gastric lavage, followed by supportive therapy for the cardiorespiratory systems if required.
Croatian: Liječenje Hitno liječenje sastoji se od ispiranja želudca nakon čega slijedi potporna terapija za kardiorespiratorni sustav ako je potrebno.
English: A target absolute neutrophil count 2000-4000/μL should be aimed for, whilst maintaining platelet count > 80,000/μL.
Croatian: Trebalo bi postići ciljni apsolutni broj neutrofila 2000 - 4000/μl uz održavanje broja trombocita > 80 000/μl.
English: To decrease the risk of exposure, parents and care givers should wear disposable gloves when handling hydroxycarbamide.
Croatian: Kako bi se smanjio rizik od izloženosti, roditelji i njegovatelji trebaju nositi jednokratne rukavice pri rukovanju hidroksikarbamidom.
English: A total of 299 participants were randomised; 152 to hydroxycarbamide and 147 to matching placebo.
Croatian: Randomizirano je ukupno 299 sudionika; 152 je primalo hidroksikarbamid, a 147 odgovarajući placebo.
English: The volume of distribution following oral dosing of hydroxycarbamide is approximately equal to total body water: adult values of 0.48 - 0.90 L/kg have been reported, whilst in children a population estimate of 0.7 L/kg has been reported.
Croatian: Volumen distribucije nakon peroralne doze hidroksikarbamida približno je jednak ukupnom volumenu tjelesne vode: prijavljene su vrijednosti od 0,48 do 0,90 l/kg u odraslih, dok je u dječjoj populaciji prijavljena procjena od 0,7 l/kg.
English: This possibility should be carefully considered before administering this medicinal product to male or female patients who may contemplate conception.
Croatian: Tu je mogućnost potrebno pažljivo razmotriti prije primjene ovog lijeka u bolesnika ili bolesnica koji mogu razmišljati o začeću.
English: Toxic ranges of myelosuppression as described in section 4.2.
Croatian: Toksična mijelosupresija sukladno vrijednostima navedenima u dijelu 4.2.
English: The morphologic change resembles pernicious anaemia, but is not related to vitamin B12 or folic acid deficiency.
Croatian: Morfološka promjena nalikuje pernicioznoj anemiji, ali nije povezana s nedostatkom vitamina B12 ili folne kiseline.
English: Close monitoring of blood parameters is advised in these patients (see section 4.4).
Croatian: Preporučuje se pomno praćenje krvnih parametara u tih bolesnika (vidjeti dio 4.4.).
English: Table 1: Adverse reactions System organ class
Croatian: Tablica 1.: Nuspojave Klasifikacija organskih sustava
English: Red blood cell (RBC), mean cell volume (MCV), and foetal haemoglobin (HbF) levels should be monitored for evidence of consistent or progressive laboratory response.
Croatian: Treba pratiti razinu crvenih krvnih stanica, srednji stanični volumen (engl. mean cell volume, MCV) i vrijednost fetalnog hemoglobina (HbF) kako bi se utvrdilo postojanje konzistentnog ili progresivnog laboratorijskog odgovora.
English: Platelets (×109/L)
Croatian: Bijele krvne stanice (×109/l)
English: In a single dose study in children with Sickle Cell Disease, the mean half-life was reported to be 1.7 hours.
Croatian: U ispitivanju jednokratnog doziranja na djeci s bolešću srpastih stanica zabilježena srednja vrijednost poluvijeka iznosila je 1,7 sati.
English: It is unknown whether this leukaemogenic effect is secondary to hydroxycarbamide or associated with the patient's underlying disease.
Croatian: Nije poznato je li taj leukemogeni učinak sekundarni učinak hidroksikarbamida ili je povezan s osnovnom bolešću bolesnika.
English: Take the medicine pack and this leaflet with you.
Croatian: Sa sobom ponesite ambalažu lijeka i ovu uputu o lijeku.
English: Spillages must be wiped immediately.
Croatian: Proliveni lijek mora se odmah obrisati.
English: Secondary outcomes included the decrease in frequency of blood transfusions and hospitalizations, and increase in HbF levels.
Croatian: Sekundarni ishodi uključivali su smanjenje učestalosti transfuzija krvi i hospitalizacija te povećanje razine HbF.
English: The physician educational material should contain:
Croatian: Materijali za obuku liječnika trebaju sadržavati sljedeće:
English: Severe renal impairment (CrCl < 30 ml/min).
Croatian: Teško oštećenje funkcije bubrega (CrCl < 30 ml/min).
English: Hence, no interaction is to be expected in case of concomitant administration with substances being substrates of cytochromes P450 or P-gp.
Croatian: Stoga se ne očekuje interakcija u slučaju istodobne primjene tvari koje su supstrati citokroma P450 ili P-glikoproteina.
English: P value1
Croatian: P vrijedn ost1
English: See section 2 “Xromi contains methyl parahydroxybenzoate”.
Croatian: Vidjeti dio 2 „Xromi sadrži metilparahidroksibenzoat”.
English: The smaller 3 ml syringe (red), marked from 0.5 ml to 3 ml, is for measuring doses of less than or equal to 3 ml.
Croatian: Manja štrcaljka od 3 ml (crvena), označena od 0,5 ml do 3 ml, namijenjena je za mjerenje doza koje su manje ili jednake količini od 3 ml.
English: Hydroxycarbamide is an orally active antineoplastic agent.
Croatian: Hidroksikarbamid je oralno aktivni antineoplastični lijek.
English: Hydroxycarbamide may also delay plasma iron clearance and reduce the rate of iron utilisation by erythrocytes but it does not appear to alter the red blood cell survival time.
Croatian: Primjena hidroksikarbamida također može odgoditi klirens željeza iz plazme i smanjiti brzinu iskorištavanja željeza u eritrocitima, no čini se da ne mijenja vrijeme preživljavanja crvenih krvnih stanica.
English: - Do not use this medicine after the expiry date which is stated on the carton and the bottle after
Croatian: - Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i bočici iza oznake EXP.
English: o Teratogenicity and male fertility; Need for contraception; Breast feeding; o Growth follow-up in children; - Key signs and symptoms of serious adverse reactions; - Information on crisis or infections; When to seek urgent attention from the health care provider
Croatian: o Praćenje rasta djece; - Ključni znakovi i simptomi ozbiljnih nuspojava; - Informacije o krizama ili infekcijama; Kada zatražiti hitnu pomoć liječnika
English: Studies have shown that there is an analytical interference of hydroxycarbamide with the enzymes (urease, uricase, and lactic dehydrogenase) used in the determination of urea, uric acid, and lactic acid, rendering falsely elevated results of these in patients treated with hydroxycarbamide.
Croatian: Ispitivanja su pokazala da postoji analitička interferencija hidroksikarbamida s enzimima (ureaza, urikaza i laktat dehidrogenaza) koji se koriste za određivanje vrijednosti uree, mokraćne kiseline i mliječne kiseline, što uzrokuje lažno povišene rezultate u bolesnika liječenih hidroksikarbamidom.
English: In a comparative bioavailability study in healthy adult volunteers (n=28), 500 mg of hydroxycarbamide oral solution was demonstrated to be bioequivalent to the reference 500 mg capsule, with respect to both the peak concentration and area under the curve.
Croatian: U komparativnom ispitivanju bioraspoloživosti u zdravih odraslih dobrovoljaca (n = 28) dokazano je da je 500 mg oralne otopine hidroksikarbamida bioekvivalentno referentnoj kapsuli od 500 mg s obzirom na vršnu koncentraciju i područje ispod krivulje.
English: These vasculitic toxicities were reported most often in patients with a history of, or currently receiving, interferon therapy (see section 4.4).
Croatian: Takvi oblici vaskulitične toksičnosti najčešće su zabilježeni u bolesnika koji su u prošlosti primali ili trenutačno primaju terapiju interferonom (vidjeti dio 4.4.).
English: Peripheral neuropathy, which was severe in some cases, has been reported in HIV-infected patients receiving hydroxycarbamide in combination with anti-retroviral medicinal products, including didanosine, with or without stavudine (see section 4.4).
Croatian: Periferna neuropatija, koja je u nekim slučajevima bila teška, zabilježena je u bolesnika zaraženih HIV-om koji su primali hidroksikarbamid u kombinaciji s antiretrovirusnim lijekovima, uključujući didanozin u kombinaciji sa stavudinom ili bez njega (vidjeti dio 4.4.).
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON
Croatian: PODATCI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA
English: Dose was reduced by 50% for bone marrow toxicity.
Croatian: Doza je smanjena za 50 %
English: Hydroxycarbamide must not be used in combination with anti-retroviral medicinal products for HIV
Croatian: Hidroksikarbamid se ne smije primjenjivati u kombinaciji s antiretrovirusnim lijekovima za liječenje
English: The educational programme is aimed to ensure the safe and effective use of the product, to minimise the risks listed below and to reduce the burden of adverse reactions with Xromi.
Croatian: Program obuke ima za cilj osigurati sigurnu i učinkovitu uporabu lijeka, smanjiti rizike navedene u nastavku kao i nuspojave lijeka Xromi.
English: Patients treated with hydroxycarbamide in combination with didanosine, stavudine, and indinavir showed a median decline in CD4 cells of approximately 100/mm3.
Croatian: U bolesnika liječenih hidroksikarbamidom u kombinaciji s didanozinom, stavudinom i indinavirom primijećen je medijan smanjenja broja CD4 stanica od oko 100/mm3.
English: Adverse reactions affecting the skin and subcutaneous tissue such as darkening of the skin nail beds, dry skin, skin ulcers, and alopecia tend to occur following several years of long-term daily maintenance therapy.
Croatian: Nuspojave koje utječu na kožu i potkožno tkivo, kao što su zatamnjenje kože na ležištu nokta, suha koža, kožni ulkusi i alopecija obično se javljaju nakon nekoliko godina dugotrajne svakodnevne terapije održavanja.
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom planu upravljanja rizikom (RMP), koji se nalazi u modulu 1.8.2.
English: Hydroxycarbamide treatment should be supervised by a physician or other healthcare professionals experienced in the management of patients with Sickle Cell Disease.
Croatian: Liječenje hidroksikarbamidom treba nadzirati liječnik ili drugi zdravstveni radnici s iskustvom u liječenju bolesnika s bolešću srpastih stanica.
English: Although the mechanism of action has not yet been clearly defined, hydroxycarbamide appears to act by interfering with synthesis of DNA by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or protein.
Croatian: Iako mehanizam djelovanja još nije jasno utvrđen, čini se da hidroksikarbamid djeluje tako da ometa sintezu DNK djelujući kao inhibitor ribonukleotid reduktaze, bez utjecaja na sintezu ribonukleinske kiseline ili proteina.
English: Hydroxycarbamide distributes rapidly throughout the human body, enters the cerebrospinal fluid, appears in peritoneal fluid and ascites, and concentrates in leukocytes and erythrocytes.
Croatian: Hidroksikarbamid se brzo distribuira po ljudskom tijelu, ulazi u cerebrospinalnu tekućinu, prisutan je u peritonealnoj tekućini i ascitesu te se koncentrira u leukocitima i eritrocitima.
English: Hydroxycarbamide may produce bone marrow suppression; leukopenia is generally its first and most common manifestation.
Croatian: Primjena hidroksikarbamida može dovesti do supresije koštane srži, a leukopenija je uglavnom njezin prvi i najčešći znak.
English: To minimise air bubbles, the bottle should not be shaken prior to dosing.
Croatian: Kako bi se mjehurići zraka sveli na najmanju moguću mjeru, bočicu se ne smije tresti prije doziranja.
English: Patients should be advised not to drive or operate machines, if dizziness is experienced while taking hydroxycarbamide.
Croatian: Bolesnike je potrebno savjetovati da ne upravljaju vozilima i ne rade na strojevima ako osjete omaglicu dok uzimaju hidroksikarbamid.
English: There was a statistically significant reduction in time to peak concentration with hydroxycarbamide oral solution compared to the reference 500 mg capsule (0.5 versus 0.75 hours, p = 0.0467), indicating a faster rate of absorption.
Croatian: Došlo je do statistički značajnog smanjenja u vremenu postizanja vršne koncentracije pri primjeni oralne otopine hidroksikarbamida u odnosu na referentnu kapsulu od 500 mg (0,5 naspram 0,75 sati, p = 0,0467), što ukazuje na bržu apsorpciju.
English: If Xromi comes into contact with skin, eyes or nose, it should be washed immediately and thoroughly with soap and water.
Croatian: Ako Xromi dođe u kontakt s kožom, očima ili nosom, to područje treba odmah temeljito oprati vodom i sapunom.
English: The sickle cells also get stuck in blood vessels, blocking blood flow.
Croatian: Osim toga, srpaste stanice zapinju u krvnim žilama i blokiraju krvotok.
English: Elevated liver enzymes, Hepatotoxicity
Croatian: Povišene vrijednosti enzima jetre, hepatotoksičnost
English: Embryotoxicity manifesting as decreased foetal viability, reduced live litter sizes, and developmental delays has been reported in species including mice, hamsters, cats, dogs, and monkeys at doses comparable to human doses.
Croatian: Embriotoksičnost se očitovala u smanjenom preživljavanju fetusa, manjem broju živih mladunaca i zastojima u razvoju, a zabilježena je u više vrsta uključujući miševe, hrčke, mačke, pse i majmune u dozama koje su usporedive s dozama u ljudi.
English: The total body clearance of hydroxycarbamide in adult patients with Sickle Cell Disease is 0.17L/h/kg.
Croatian: Ukupni tjelesni klirens hidroksikarbamida u odraslih bolesnika s bolešću srpastih stanica iznosi 0,17 l/h/kg.
English: The study reported 16 patients out of 22 (73%) did not require any hospitalisation for painful episodes when treated with hydroxycarbamide as compared with only 3 of 22 (14%) when treated with placebo.
Croatian: U okviru ispitivanja zabilježeno je da u 16 od 22 bolesnika (73 %) liječenih hidroksikarbamidom nije bila potrebna hospitalizacija zbog bolnih epizoda, u usporedbi sa samo 3 od 22 bolesnika (14 %)
English: The extent of protein binding of hydroxycarbamide is unknown.
Croatian: Opseg vezanja hidroksikarbamida za proteine nije poznat.
English: Elderly patients may be more sensitive to the myelosuppressive effects of hydroxycarbamide, and may require a lower dosage regimen.
Croatian: Stariji bolesnici mogu biti osjetljiviji na mijelosupresivne učinke hidroksikarbamida te im može trebati smanjenje režima doziranja.
English: The larger 12 ml syringe (white), marked 1 ml to 12 ml, is for measuring doses of more than 3 ml.
Croatian: Veća štrcaljka od 12 ml (bijela), označena od 1 ml do 12 ml, namijenjena je za mjerenje doza koje su veće od 3 ml.
English: Both male and female patients should be advised to use contraceptive measures before and during treatment with hydroxycarbamide.
Croatian: Bolesnicima i bolesnicama treba savjetovati da prije i tijekom liječenja hidroksikarbamidom primjenjuju kontracepcijske mjere.
English: The risk of vasculitic toxicities is increased in patients who receive prior or concomitant interferon therapy.
Croatian: Rizik od vaskulitične toksičnosti povećan je u bolesnika koji su prethodno primali ili istodobno primaju terapiju interferonom.
English: Other commonly reported adverse effects also include nausea, constipation, headache, and dizziness.
Croatian: Ostale često prijavljene nuspojave uključuju mučninu, zatvor, glavobolju i omaglicu.
English: Skin ulcer, oral, nail and skin hyperpigmentation, dry skin, alopecia
Croatian: Kožni ulkus, hiperpigmentacija usne šupljine, noktiju i kože, suha koža, alopecija
English: Very common reversible oligo- and azoo-spermia have been observed in man, although these disorders are also associated with the underlying disease.
Croatian: Vrlo često su u muškaraca primijećene reverzibilna oligospermija i azoospermija, iako se ti poremećaji mogu povezati i s već postojećom bolešću.
English: - Keep the bottle tightly closed to prevent spoilage of the medicine and reduce the risk of accidental spillage.
Croatian: Držite bočicu čvrsto zatvorenu kako biste zaštitili cjelovitost lijeka i smanjili rizik od slučajnog izlijevanja.
English: Patients were randomly assigned to receive either hydroxycarbamide first for 6 months, followed by placebo for 6 months, or placebo first, followed by hydroxycarbamide for 6 months.
Croatian: Nasumično su odabrani bolesnici koji su prvih šest mjeseci primali hidroksikarbamid, nakon čega su šest mjeseci primali placebo, ili su prvo primali placebo, a potom su šest mjeseci primali hidroksikarbamid.
English: Your doctor or pharmacist will advise which syringe to use depending on the dose that has been prescribed.
Croatian: Liječnik ili ljekarnik savjetovat će vas o tome koju štrcaljku upotrijebiti ovisno o propisanoj dozi.
English: Once a maximum tolerated dose is established, laboratory safety monitoring should include full blood cell count with white cell differential, reticulocyte count, and platelet count every 2-3 months.
Croatian: Nakon što se utvrdi najviša podnošljiva doza, laboratorijsko praćenje sigurnosti treba uključivati izradu kompletne krvne slike s diferencijalnom bijelom krvnom slikom, brojem retikulocita i brojem trombocita svaka dva do tri mjeseca.
English: The complete status of the blood, including bone marrow examination, if indicated, as well as kidney function and liver function should be determined prior to, and repeatedly during, treatment.
Croatian: Potrebno je napraviti kompletnu krvnu sliku, uključujući pregled koštane srži ako je indicirano, te ocijeniti funkciju bubrega i funkciju jetre prije liječenja te više puta tijekom liječenja.
English: In adult cancer patients, hydroxycarbamide was eliminated with a half-life of approximately 2-3 hours.
Croatian: U odraslih bolesnika s rakom, poluvijek eliminacije hidroksikarbamida iznosio je približno dva do tri sata.
English: The myelosuppressive activity may be potentiated by previous or concomitant radiotherapy or cytotoxic therapy.
Croatian: Mijelosupresivno djelovanje može biti pojačano prethodnom ili istodobnom radioterapijom ili citotoksičnom terapijom.
English: In patients, whose CrCl was below 60 ml/min or patients with End Stage Renal Disease the mean exposure to hydroxycarbamide was approximately 64% higher than in patients with normal renal function.
Croatian: U bolesnika čiji je CrCl bio niži od 60 ml/min ili u bolesnika u završnom stadiju bolesti bubrega srednja vrijednost izloženosti hidroksikarbamidu bila je otprilike 64 % viša no u bolesnika s normalnom bubrežnom funkcijom.
English: It is important that you use the correct dosing syringe for your medicine.
Croatian: Važno je da kod uzimanja lijeka upotrebljavate odgovarajuće štrcaljke za doziranje.
English: Severe anaemia must be corrected with whole blood replacement before initiating therapy with hydroxycarbamide.
Croatian: Teška anemija mora se korigirati transfuzijom pune krvi prije no što se započne liječenje hidroksikarbamidom.
English: If, during treatment, anaemia occurs, correct without interrupting hydroxycarbamide therapy.
Croatian: Ako tijekom terapije nastupi anemija, potrebno ju je korigirati bez prekidanja liječenja hidroksikarbamidom.
English: The usual starting dose for adults, adolescents and children over the age of 2 years is 15 mg/kg each day and the usual maintenance dose is between 20-25 mg/kg.
Croatian: adolescente i djecu stariju od dvije godine je 15 mg/kg na dan, a uobičajena doza održavanja je između 20 i 25 mg/kg.
English: Parents / care givers and patients should be advised to keep hydroxycarbamide out of the sight and reach of children.
Croatian: Roditelje/njegovatelje i bolesnike potrebno je savjetovati da hidroksikarbamid čuvaju izvan pogleda i dohvata djece.
English: Ulysses House Foley Street, Dublin 1 D01 W2T2
Croatian: Foley Street, Dublin 1
English: In addition patients should conduct self-inspection of the skin during the treatment and after discontinuation of the therapy with hydroxycarbamide and be screened for secondary malignancies during routine follow-up visits.
Croatian: Dodatno, bolesnici bi trebali samostalno pregledavati kožu za vrijeme liječenja i nakon prekida terapije hidroksikarbamidom, a tijekom redovitih kontrolnih posjeta treba napraviti pretrage na sekundarne zloćudne bolesti.
English: Not significant
Croatian: Nije statistički značajno
English: If you are not sure how much medicine to take, always ask your doctor or nurse.
Croatian: Ako niste sigurni koliko lijeka uzeti, uvijek se obratite svom liječniku ili medicinskoj sestri.
English: In the event of bone marrow suppression, haematological recovery usually occurs within two weeks of withdrawal of hydroxycarbamide.
Croatian: U slučaju supresije koštane srži krvna se slika obično oporavlja unutar dva tjedna nakon prestanka uzimanja hidroksikarbamida.
English: Close monitoring of blood parameters is advised in these patients.
Croatian: Preporučuje se pomno praćenje krvnih parametara u tih bolesnika.
English: How to take Xromi
Croatian: Kako uzimati Xromi
English: Patients on hydroxycarbamide should be made aware of the theoretical risks to the foetus.
Croatian: Bolesnici koji primaju hidroksikarbamid moraju biti upoznati s teoretskim rizicima za fetus.
English: Xromi is indicated for the prevention of vaso-occlusive complications of Sickle Cell Disease in patients over 2 years of age.
Croatian: Xromi je indiciran za prevenciju vazookluzivnih komplikacija bolesti srpastih stanica u bolesnika starijih od dvije godine.
English: Xromi is for oral use.
Croatian: Xromi je namijenjen za peroralnu primjenu.
English: Patients should be monitored for vital signs, blood and urine chemistry, renal and hepatic function and full blood counts for at least 3 weeks.
Croatian: Bolesnici trebaju najmanje tri tjedna biti pod nadzorom radi praćenja vitalnih znakova, utvrđivanja kemijskog sastava krvi i urina, funkcije bubrega i jetre i kompletne krvne slike.
English: Hydroxycarbamide therapy can then be re-initiated at a lower dose (see section 4.2).
Croatian: Potom se ponovno može započeti liječenje nižom dozom hidroksikarbamida (vidjeti dio 4.2.).
English: There are no data that support specific guidance for dose adjustment in patients with hepatic impairment, but, due to safety considerations, hydroxycarbamide is contraindicated in patients with severe hepatic impairment (see section 4.3).
Croatian: Ne postoje podatci koji podupiru specifične smjernice za prilagođavanje doze u bolesnika s oštećenjem funkcije jetre, ali je hidroksikarbamid iz sigurnosnih razloga kontraindiciran u bolesnika s teškim oštećenjem funkcije jetre (vidjeti dio 4.3.).
English: Once the blood count had recovered, treatment was restarted at 2.5 mg/kg per day less than the toxic dose.
Croatian: Nakon oporavka krvne slike ponovno je započeto liječenje primjenom doze koja je za 2,5 mg/kg na dan niža od toksične doze.
English: Do not shake.
Croatian: Ne smije se tresti.
English: Pregnancy (see section 4.6)
Croatian: Trudnoća (vidjeti dio 4.6.).
English: Xromi is used to prevent the complications of blocked blood vessels caused by Sickle Cell Disease in patients over 2 years of age.
Croatian: Xromi se uzima za prevenciju komplikacija blokiranih krvnih žila uzrokovanih bolešću srpastih stanica u bolesnika starijih od dvije godine.
English: If you are not sure about how much medicine to draw into the syringe, always ask your doctor or nurse for advice.
Croatian: Ako niste sigurni koliko lijeka povući u štrcaljku, uvijek potražite savjet svog liječnika ili medicinske sestre.