FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Medicines Agency has waived the obligation to submit the results of studies with Diovan in all subsets of the paediatric population in heart failure and heart failure after recent myocardial infarction.
Slovenian: Evropska agencija za zdravila je odstopila od obveze za predložitev rezultatov študij z zdravilom Diovan za vse skupine pediatri ne populacije za sr no popuš anje in za sr no popuš anje po nedavnem miokardnem infarktu.
English: • if you are below 18 years of age and you take Diovan in combination with other medicines that inhibit the renin angiotensin aldosterone system (medicines that lower blood pressure), your doctor may check your kidney function and the amount of potassium in your blood at regular intervals.
Slovenian: • e ste stari manj kot 18 let in jemljete zdravilo Diovan v kombinaciji z drugimi zdravili, ki zavirajo sistem renin-angiotenzin-aldosteron (zdravila, ki znižujejo krvni tlak), vam bo morda zdravnik v rednih intervalih preverjal delovanje vaših ledvic in koli ino kalija v vaši krvi,
English: Diovan belongs to a class of medicines known as angiotensin II receptor antagonist, which help to control high blood pressure.
Slovenian: Zdravilo Diovan sodi v skupino zdravil, znano pod imenom antagonisti receptorjev angiotenzina II, ki pomagajo uravnavati visok krvni tlak.
English: A somewhat higher systemic exposure to valsartan was observed in some elderly subjects than in young subjects; however, this has not been shown to have any clinical significance.
Slovenian: Pri nekaterih starejših bolnikih so opazili nekoliko ve jo sistemsko izpostavljenost valsartanu v primerjavi z mladimi osebami; vendar se ni pokazalo, da bi imelo to kakšen klini en pomen.
English: The applicant will initiate a scientific dialogue via the CHMP's Scientific Advice with the involvement of the PDCO for protocol assistance with the aim of gaining further insight on a hypertensive clinical trial in younger children with valsartan and to define objectives and design parameters in investigating the efficacy in this population.
Slovenian: Predlagatelj bo za el strokovni dialog s pomo jo strokovnih nasvetov odbora CHMP ob vklju itvi odbora PDCO za pomo pri protokolu, katerega cilj je pridobiti nadaljnji vpogled v klini no preskušanje hipertenzije pri majhnih otrocih, ki prejemajo valsartan, ter dolo iti cilje in oblikovati parametre za prou evanje u inkovitosti zdravila v tej populaciji.
English: High blood pressure increases the workload on the heart and arteries.
Slovenian: Visok krvni tlak poveuje obremenitev srca in arterij.
English: The rats in the juvenile valsartan study were dosed up to day 70, and effects on renal maturation (postnatal 4-6 weeks) cannot be excluded.
Slovenian: V študiji valsartana pri mladih živalih so podgane prejemale valsartan tudi do 70. dne in vpliva na dozorevanje ledvic (v 4. do 6. tednu po rojstvu) ni mogo e izklju iti.
English: Valsartan is primarily eliminated by biliary excretion in faeces (about 83% of dose) and renally in urine (about 13% of dose), mainly as unchanged drug.
Slovenian: Valsartan se izlo a predvsem z blatom (približno 83 % odmerka) in preko ledvic z urinom (približno 13 % odmerka), ve inoma v obliki nespremenjenega zdravila.
English: DATE OF REVISION OF THE TEXT [To be completed nationally]
Slovenian: DATUM ZADNJE REVIZIJE BESEDILA [Izpolni država lanica]
English: • certain type of pain killers called non-steroidal anti-inflammatory medicines (NSAIDs).
Slovenian: • nekatere vrste zdravil za lajšanje bole in, ki se imenujejo nesteroidna protivnetna zdravila
English: Sodium and/or volume depletion should be corrected before starting treatment with Diovan, for example by reducing the diuretic dose.
Slovenian: Pomanjkanje natrija in hipovolemijo je treba pred za etkom zdravljenja z zdravilom Diovan odpraviti, na primer z zmanjšanjem odmerka diuretika.
English: Within each frequency grouping, adverse reactions are ranked in order of decreasing seriousness.
Slovenian: Znotraj vsake skupine pogostnosti so neželeni u inki navedeni po padajo i resnosti.
English: Due to the lack of experience with concomitant use of valsartan and lithium, this combination is not recommended.
Slovenian: Zaradi pomanjkanja izkušenj o so asni uporabi valsartana in litija ta kombinacija ni priporo ena.
English: The primary endpoint was time to all-cause mortality.
Slovenian: Primarni cilj opazovanja je bil as do smrti (umrljivost iz vseh vzrokov).
English: Irrespective of treatment, mortality was lower in the group of patients treated with a beta blocker, suggesting that the known beta blocker benefit in this population was maintained in this trial.
Slovenian: Ne glede na vrsto zdravljenja je bila umrljivost manjša v skupini bolnikov, ki so se zdravili z antagonistom adrenergi nih receptorjev beta, kar kaže, da so se znane koristi antagonistov adrenergi nih receptorjev beta v tej skupini bolnikov v tem preskušanju ohranile.
English: The apparent clearance of valsartan following oral administration is approximately 4.5 l/h.
Slovenian: Navidezni o istek valsartana po peroralni aplikaciji je približno 4,5 l/h.
English: Valsartan is highly bound to plasma protein and is unlikely to be removed by dialysis.
Slovenian: Valsartan je v veliki meri vezan na beljakovine v plazmi, zato ni verjetno, da bi se izlo al med dializo.
English: In marmosets at similar doses, the changes were similar though more severe, particularly in the kidney where the changes developed to a nephropathy which included raised urea and creatinine.
Slovenian: Pri marmozetkah so bile pri podobnih odmerkih spremembe podobne, vendar bolj resne, še zlasti v ledvicah, kjer so se pojavile spremembe, podobne nefropatiji, ki so vklju evale zvišanje ravni se nine in kreatinina.
English: • if you have lost a lot of fluid (dehydration) caused by diarrhoea, vomiting, or high doses of water tablets (diuretics).
Slovenian: • e izgubite veliko teko ine (dehidracija) zaradi driske, bruhanja ali velikih odmerkov tablet za odvajanje vode (diuretikov),
English: The antihypertensive effect persists over 24 hours after dosing.
Slovenian: Antihipertenzivni u inek traja 24 ur po odmerjanju.
English: 4.6 Fertility, pregnancy and lactation
Slovenian: 4.6 Plodnost, nose nost in dojenje
English: • medicines that increase the amount of potassium in your blood.
Slovenian: • zdravila, ki lahko zvišajo koli ino kalija v vaši krvi.
English: • low blood pressure with or without symptoms such as dizziness and fainting when standing up
Slovenian: • nizek krvni pritisk s simptomi, kot sta omoti nost in izguba zavesti pri vstajanju, ali brez teh simptomov
English: The mean daily dose of Diovan in Val-HeFT was 254 mg.
Slovenian: Povpre ni odmerek zdravila Diovan na dan v študiji Val-HeFT je bil 254 mg.
English: Adult patients with high blood pressure: The usual dose is 80 mg daily.
Slovenian: Odrasli bolniki z visokim krvnim tlakom: Obi ajni odmerek je 80 mg na dan.
English: Reductions in systolic blood pressure were comparable in patients receiving valsartan (15 mmHg) and enalapril (14 mm Hg) (non-inferiority p-value <0.0001).
Slovenian: Znižanje sistoli nega krvnega tlaka je bilo pri bolnikih, ki so prejemali valsartan (za 15 mmHg) primerljivo s tistim pri bolnikih, ki so prejemali enalapril (za 14 mmHg) (vrednost p za ne-inferiornost <0,0001).
English: In hypertensive patients with type 2 diabetes and microalbuminuria, valsartan has been shown to reduce the urinary excretion of albumin.
Slovenian: Pri hipertenzivnih bolnikih s sladkorno boleznijo tipa 2 in z mikroalbuminurijo se je pokazalo, da valsartan zmanjša izlo anje albumina v urinu.
English: A causal relationship to Diovan has not been established.
Slovenian: Vzro ne povezanosti z zdravilom Diovan niso ugotovili.
English: In the first study, the efficacy of valsartan was confirmed compared to placebo but a dose-response could not be demonstrated.
Slovenian: V prvi študiji so dokazali u inkovitost valsartana v primerjavi s placebom, niso pa mogli potrditi odvisnosti odziva od odmerka.
English: However, if it is almost time for your next dose, skip the dose you missed.
Slovenian: e je že skoraj as za naslednji odmerek, presko ite odmerek, ki ste ga pozabili vzeti.
English: Hypertrophy of the renal juxtaglomerular cells was also seen in both species.
Slovenian: Pri obeh vrstah so opazili tudi hipertrofijo ledvi nih jukstaglomerularnih celic.
English: The frequency of some side effects may vary depending on your condition.
Slovenian: Pogostnost nekaterih neželenih u inkov lahko niha glede na vaše stanje.
English: 5.3 Preclinical safety data
Slovenian: 5.3 Predklini ni podatki o varnosti
English: Baseline therapy included ACE inhibitors (93%), diuretics (86%), digoxin (67%) and beta blockers (36%).
Slovenian: Osnovno zdravljenje je vklju evalo zaviralce ACE (93 %), diuretike (86 %), digoksin (67 %) in antagoniste adrenergi nih receptorjev beta (36 %).
English: Following intravenous administration, plasma clearance of valsartan is about 2 l/h and its renal clearance is 0.62 l/h (about 30% of total clearance).
Slovenian: Po intravenski uporabi je plazemski o istek valsartana približno 2 l/uro, njegov ledvi ni o istek pa 0,62 l/uro (približno 30 % celotnega o istka).
English: Pregnancy and breast-feeding Ask your doctor or pharmacist for advice before taking any medicine.
Slovenian: Nose nost in dojenje Posvetujte se z zdravnikom ali s farmacevtom, preden vzamete katerokoli zdravilo.
English: All cause mortality was similar (p=NS) in the valsartan (19.7%) and placebo (19.4%) groups.
Slovenian: Umrljivost iz vseh vzrokov je bila podobna (p = NS) v skupini z valsartanom (19,7 %) in s placebom (19,4 %).
English: In clinically stable patients, therapy may be initiated as early as 12 hours after a myocardial infarction.
Slovenian: Pri klini no stabilnih bolnikih je mogo e zdravljenje za eti že 12 ur po miokardnem infarktu.
English: This makes it all the more important for you to keep your appointments with the doctor even if you are feeling well.
Slovenian: Zato je zelo pomembno, da hodite na preglede k zdravniku, tudi e se po utite dobro.
English: Overall, the three dose levels of valsartan (low, medium and high) significantly reduced systolic blood pressure by 8, 10, 12 mm Hg from the baseline, respectively.
Slovenian: V celoti je pri treh ravneh odmerkov valsartana (nizki, srednji in visoki) prišlo do pomembnega znižanja sistoli nega krvnega tlaka za 8, 10 oziroma 12 mmHg od izhodiš nih vrednosti.
English: Composite mortality and morbidity risk was significantly reduced by 18.3% (95% CI: 8% to 28%) with valsartan compared with placebo (31.0% vs. 36.3%).
Slovenian: Tveganje glede sestavljene umrljivosti in obolevnosti je bilo z valsartanom zna ilno manjše za 18,3 % (95 % IZ: 8% do 28%) v primerjavi s placebom (31,0% v primerjavi z 36,3%).
English: In a double-blind randomized study in 90 children aged 1 to 6 years, which was followed by a one-year open-label extension, two deaths and isolated cases of marked liver transaminases elevations were observed.
Slovenian: V dvojno slepi randomizirani študiji z 90 otroci, ki so bili stari od 1 leta do 6 let, in v enoletnem odprtem podaljšanju te študije so zabeležili dva primera smrti in posamezne primere izrazitega zvišanja koncentracije jetrnih aminotransferaz.
English: The study had two primary endpoints: all cause mortality (time to death) and composite mortality and heart failure morbidity (time to first morbid event) defined as death, sudden death with resuscitation, hospitalisation for heart failure, or administration of intravenous inotropic or vasodilator agents for four hours or more without hospitalisation.
Slovenian: Študija je imela dva primarna cilja opazovanja: umrljivost iz vseh vzrokov ( as do smrti) in cilj opazovanja, sestavljen iz umrljivosti in obolevnosti zaradi sr nega popuš anja ( as do prvega bolezenskega dogodka), ki je bil opredeljen kot smrt, nenadna smrt z oživljanjem, hospitalizacija zaradi sr nega popuš anja ali dajanje intravenskih inotropnih zdravil ali vazodilatorjev štiri ure ali ve brez hospitalizacije.
English: What Diovan is and what it is used for Before you take Diovan How to take Diovan Possible side effects How to store Diovan Further information
Slovenian: Kaj je zdravilo Diovan in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Diovan Kako jemati zdravilo Diovan Možni neželeni u inki
English: Short-term administration of Diovan to twelve patients with renovascular hypertension secondary to unilateral renal artery stenosis did not induce any significant changes in renal haemodynamics, serum creatinine, or blood urea nitrogen (BUN).
Slovenian: Kratkotrajna uporaba zdravila Diovan pri dvanajstih bolnikih z enostransko stenozo ledvi ne arterije in renovaskularno hipertenzijo ni povzro ila pomembnih sprememb ledvi ne hemodinamike, koncentracije kreatinina v serumu ali dušika se nine v krvi (blood urea nitrogen - BUN).
English: • if you have severe liver disease.
Slovenian: • e imate hudo bolezen jeter,
English: In some cases your doctor may prescribe higher doses (e.g. 160 mg or 320 mg).
Slovenian: V nekaterih primerih lahko zdravnik predpiše višje odmerke (npr. 160 mg ali 320 mg).
English: Important information about some of the ingredients of Diovan [To be completed nationally]
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Diovan [Izpolni država lanica]
English: If you have further questions on the use of this product, ask your doctor or pharmacist.
Slovenian: e imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom ali s farmacevtom.
English: In a second study in which 75 children aged 1 to 6 years were randomised, no significant liver transaminase elevations or death occurred with valsartan treatment.
Slovenian: V drugi študiji, v kateri so randomizirali 75 otrok, starih od 1 leta do 6 let, pri zdravljenju z valsartanom ni prišlo do bistvenega zvišanja koncentracije jetrnih aminotransferaz ali do smrti.
English: There was no difference between valsartan and captopril in all-cause mortality based on age, gender, race, baseline therapies or underlying disease.
Slovenian: Med valsartanom in kaptoprilom ni bilo razlik glede umrljivosti iz vseh vzrokov po starosti, spolu, rasi, predhodnem zdravljenju in osnovni bolezni.
English: Consequently, a clinical relevance in children <1 year of age cannot be excluded, while preclinical data do not indicate a safety concern for children older than 1 year.
Slovenian: Iz tega razloga ni mogo e izklju iti možnosti, da bi bili navedeni pojavi lahko klini no pomembni pri otrocih, ki so mlajši od 1 leta, hkrati pa zaradi predklini nih podatkov ni nobenih pomislekov glede varne uporabe zdravila pri otrocih, ki so starejši od 1 leta.
English: 160 mg 80 kg to 160 kg 320 mg
Slovenian: 80 kg do 160 kg 320 mg
English: For example, side effects such as dizziness, and decreased kidney function, were seen less frequently in adult patients treated with high blood pressure than in adult patients treated for heart failure or after a recent heart attack.
Slovenian: Tako so na primer neželeni u inki kot sta omoti nost ali zmanjšano delovanje ledvic manj pogosta pri odraslih bolnikih, ki se zdravijo zaradi visokega krvnega pritiska, kot pri odraslih bolnikih, ki se zdravijo zaradi sr nega popuš anja ali po nedavnem sr nem infarktu.
English: Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy As with all other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or hypertrophic obstructive cardiomyopathy (HOCM).
Slovenian: Stenoza aortne in mitralne zaklopke, obstruktivna hipertrofi na kardiomiopatija Kot pri uporabi drugih vazodilatatorjev je potrebna posebna pozornost pri bolnikih z aortno ali mitralno stenozo ali s hipertrofi no obstruktivno kardiomiopatijo (hypertrophic obstructive cardiomyopathy - HOCM).
English: The maximum daily dose administered in clinical trials is 320 mg in divided doses.
Slovenian: Najve ji dnevni odmerek, ki so ga uporabili v klini nih preskušanjih, je bil 320 mg v razdeljenih odmerkih.
English: Doses higher than those listed have not been studied and are therefore not recommended.
Slovenian: Odmerkov, ki presegajo navedene v preglednici, niso prou evali in jih zato ni priporo eno uporabljati.
English: For therapeutic doses of valsartan in humans, the hypertrophy of the renal juxtaglomerular cells does not seem to have any relevance.
Slovenian: Kaže, da terapevtski odmerki valsartana pri ljudeh ne vplivajo na hipertrofijo ledvi nih jukstaglomerularnih celic.
English: You can take Diovan with or without food.
Slovenian: Zdravilo Diovan je mogo e jemati s hrano ali brez nje.
English: In patients with mild to moderate hepatic impairment without cholestasis, the dose of valsartan should not exceed 80 mg.
Slovenian: Pri bolnikih z blago do zmerno okvaro jeter brez holestaze odmerek valsartana ne sme presegati 80 mg.
English: - Second and third trimester of pregnancy (see sections 4.4 and 4.6).
Slovenian: - Drugo in tretje trimese je nose nosti (glejte poglavji 4.4 in 4.6)
English: In patients receiving an ACE inhibitor without a beta-blocker, all cause mortality was similar (p=NS) in the valsartan (21.8%) and placebo (22.5%) groups.
Slovenian: Pri bolnikih, ki so prejemali zaviralec ACE brez antagonista adrenergi nih receptorjev beta, je bila umrljivost iz vseh vzrokov podobna (p = NS) v skupini z valsartanom (21,8 %) in s placebom (22,5 %).
English: In rats, maternally toxic doses (600 mg/kg/day) during the last days of gestation and lactation led to lower survival, lower weight gain and delayed development (pinna detachment and ear-canal opening) in the offspring (see section 4.6).
Slovenian: Pri podganah so odmerki, toksi ni za mater, (600 mg/kg/dan) v zadnjih dneh brejosti in med dojenjem povzro ili zmanjšano preživetje, nižjo telesno maso, upo asnitev razvoja (neprirasel uhelj in odprt ušesni kanal) (glejte poglavje 4.6) pri potomstvu.
English: The incidence of ADRs did not appear to be related to dose or treatment duration and also showed no association with gender, age or race.
Slovenian: Pogostnost neželenih u inkov ni videti sorodna z velikostjo odmerka ali s trajanjem zdravljenja, pa tudi ne s spolom, starostjo ali raso.
English: Valsartan was also effective in prolonging the time to and reducing cardiovascular mortality, hospitalisation for heart failure, recurrent myocardial infarction, resuscitated cardiac arrest, and non-fatal stroke (secondary composite endpoint).
Slovenian: Valsartan je bil u inkovit tudi pri podaljšanju asa do kardiovaskularne smrti in zmanjševanju kardiovaskularne umrljivosti, hospitalizacij zaradi sr nega popuš anja, ponovitev miokardnega infarkta, zastoja srca z uspešnim oživljanjem in možganske kapi, ki ni smrtna (sekundarni sestavljen cilj opazovanja).
English: Diovan is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Slovenian: Uporaba zdravila Diovan ni priporo ena za matere, ki dojijo, zato lahko vaš zdravnik izbere drugo zdravljenje, e želite dojiti, še zlasti, e gre za novorojen ka ali nedonošen ka.
English: If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Slovenian: e katerikoli neželeni u inek postane resen ali e opazite katerikoli neželeni u inek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
English: Method of administration Diovan may be taken independently of a meal and should be administered with water.
Slovenian: Na in uporabe Zdravilo Diovan je mogo e jemati neodvisno od obrokov, treba pa ga je zaužiti z vodo.
English: The safety profile of valsartan was consistent with the clinical course of patients treated in the postmyocardial infarction setting.
Slovenian: Varnostne lastnosti valsartana so se ujemale s klini nim potekom pri bolnikih, ki so jih zdravili v okviru zdravljenja po miokardnem infarktu.
English: For all the ADRs reported from post-marketing experience and laboratory findings, it is not possible to apply any ADR frequency and therefore they are mentioned with a "not known" frequency.
Slovenian: Za vse neželene u inke, o katerih so poro ali na podlagi izkušenj po za etku trženja zdravila in laboratorijskih izvidov, pogostnosti ni mogo e ugotoviti, zato je njihova pogostnost navedena kot "neznana".
English: Furthermore, concomitant use of angiotensin II antagonists and NSAIDs may lead to an increased risk of worsening of renal function and an increase in serum potassium.
Slovenian: Poleg tega lahko so asna uporaba antagonistov angiotenzina II in nesteroidnih protivnetnih zdravil povzro i pove ano tveganje za poslabšanje delovanja ledvic in zvišanje koncentracije kalija v serumu.
English: The antihypertensive effect of valsartan has been evaluated in two randomised, double-blind clinical studies in 561 paediatric patients from 6 to 18 years of age.
Slovenian: Antihipertenzivno delovanje valsartana so ocenjevali v dveh randomiziranih, dvojno slepih klini nih študijah s 561 pediatri nimi bolniki v starosti od 6 do 18 let.
English: • if you are more than 3 months pregnant (it is also better to avoid Diovan in early pregnancy - see pregnancy section).
Slovenian: • e ste nose i ve kot 3 mesece (tudi v zgodnji nose nosti raje ne jemljite zdravila Diovan)glejte poglavje nose nost.
English: In some cases your doctor may prescribe higher doses (the dose can be increased to 160 mg and to a maximum of 320 mg).
Slovenian: V nekaterih primerih lahko zdravnik predpiše višje odmerke (odmerke lahko zviša na 160 mg oziroma na najve 320 mg).
English: Combined with hydrochlorothiazide, a significant additional reduction in blood pressure is achieved.
Slovenian: V kombinaciji s hidroklorotiazidom je mogo e dose i pomembno dodatno znižanje krvnega tlaka.
English: The purpose of the study was to determine the optimal dose of valsartan for reducing UAE in hypertensive patients with type 2 diabetes.
Slovenian: Namen študije je bil dolo iti optimalni odmerek valsartana za zmanjšanje izlo anja albumina z urinom pri hipertenzivnih bolnikih s sladkorno boleznijo tipa 2.
English: AUC and Cmax values of valsartan are almost proportional with increasing dose over the clinical dosing range (40 to 160 mg twice a day).
Slovenian: Vrednosti AUC in Cmax valsartana se pove ujejo linearno in so v mejah klini nega odmerjanja (40 do 160 mg dvakrat na dan) skoraj sorazmerne ve anju odmerka.
English: Consideration should be given to reducing the dose of concomitant diuretics.
Slovenian: Razmisliti je treba o zmanjšanju odmerkov so asno uporabljenih diuretikov.
English: In hypertension in children and adolescents, where underlying renal abnormalities are common, caution is recommended with the concomitant use of valsartan and other substances that inhibit the renin angiotensin aldosterone system which may increase serum potassium.
Slovenian: Pri otrocih in mladostnikih s hipertenzijo, pri katerih so pogosto prisotne tudi bolezenske spremembe ledvic, je priporo ena previdnost pri so asni uporabi valsartana in drugih u inkovin, ki zavirajo delovanje sistema renin-angiotenzin-aldosteron, kar lahko zviša koncentracijo kalija v serumu.
English: Paediatric population
Slovenian: Pediatri na populacija
English: These cases occurred in a population who had significant comorbidities.
Slovenian: Do tega je prišlo v populaciji otrok, ki so imeli so asno še druge pomembne bolezni.
English: If you have accidentally taken too many tablets, contact your doctor, pharmacist, or hospital.
Slovenian: e nehote vzamete preve tablet, pokli ite svojega zdravnika, farmacevta ali v bolnišnico.
English: The increased plasma levels of Ang II following AT1 receptor blockade with valsartan may stimulate the unblocked AT2 receptor, which appears to counterbalance the effect of the AT1 receptor.
Slovenian: Po zaviranju receptorja AT1 z valsartanom lahko zvišana koncentracija angiotenzina II v plazmi stimulira nezavrte receptorje podvrste AT2, ki, kot kaže, izravnavajo u inek receptorjev AT1.
English: - Post-myocardial infarction and/or heart failure (studied in adult patients only)
Slovenian: - Stanje po miokardnem infarktu in/ali sr no popuš anje (prou evano samo pri odraslih bolnikih)