FrancophonIA/ELRC3.0 huggingface dataset:
English: Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
Slovenian: Pred začetkom jemanja uporabo natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
English: In the open label phase of Study 1 (N = 184), the overall response rate increased to 66.7%.
Slovenian: V odprti fazi študije 1 (N = 184) se je skupna stopnja odziva povečala na 66,7 %.
English: The incidence of mild/moderate rash (all events regardless of causality) was less in patients treated for less than 16 weeks than in those treated for 16 weeks or more (mild, 33% v 63%; moderate, 29% v 43%).
Slovenian: Rahli/zmerni izpuščaji (vsi primeri ne glede na vzročnost) so se pojavljali redkeje pri bolnikih, ki so se zdravili manj kot 16 tednov v primerjavi s tistimi, ki so se zdravili za čas 16 tednov ali dlje (rahlo: 33 % napram 63 %; zmerno: 29 % napram 43 %).
English: After that, your doctor will decide how often you should apply the gel depending on the response of your KS and any side effects.
Slovenian: Za tem bo zdravnik določil, kolikokrat boste gel nanesli, in sicer odvisno od odziva KS ter morebitnih stranskih učinkov.
English: Each carton contains one tube of gel.
Slovenian: Vsaka škatla vsebuje eno tubo z gelom.
English: Carcinogenesis, mutagenesis, impairment of fertility
Slovenian: Karcinogeneza, mutageneza, oslabitev plodnosti
English: Once activated, these receptors function as ligand dependent transcription factors that regulate the expression of specific genes.
Slovenian: Ko so aktivirani, delujejo ti receptorji kot od liganda odvisni transkripcijski faktorji in uravnavajo izražanje specifičnih genov.
English: Studies have not been performed to determine the carcinogenic potential of alitretinoin.
Slovenian: Ni izvršenih študij za določitev kancerogenega potenciala alitretinoina.
English: Lesions responding during the first 12 weeks on study, initial blinded phase, confirmed over at least four study weeks (confirmation of response may have occurred after 12 weeks for some lesions in Study 1).
Slovenian: Lezije, ki so se odzvale v času prvih 12 tednov študije, začetna slepa faza, potrjeno za čas najmanj štirih tednov študije (dokaz odziva se je lahko pojavil po 12 tednih pri nekaterih lezijah v študiji 1).
English: How to apply Panretin: For cutaneous use (on the skin) only Apply Panretin twice a day to start with, once in the morning and once in the evening.
Slovenian: Kako uporabljamo zdravilo Panretin gel: samo za kožno uporabo (nanos na kožo) Na začetku nanesite dvakrat dnevno, enkrat zjutraj in enkrat zvečer.
English: Observed increases in mean heart-to-final body weight differences were attributed principally to the difference in the terminal body weights.
Slovenian: Opažena povečanja v povprečnih razlikah vrednosti razmerja »srce / končna telesna teža« so predpisali predvsem razliki v končnih telesnih težah.
English: Study 1, 6 index lesions; Study 2, up to 8 index lesions Each index lesion assessed individually for response.
Slovenian: Študija 1, 6 indeksnih lezij; študija 2, do 8 indeksnih lezij Odziv vsake indeksne lezije je bil ocenjen posebej.
English: For cutaneous use.
Slovenian: Za dermalno uporabo.
English: - Do not apply the gel on or near sensitive parts of your body such as eyes, nostrils, mouth,
Slovenian: - Gela ne nanašajte na ali blizu občutljivih delov telesa, kot so oči, nosnice, usta, ustnice, vagina,
English: The projected time for lesions that were in partial response (PR) to later attain clinical complete response (CCR) was 168 days.
Slovenian: Napovedani čas za lezije, ki so naprej pokazale delni odziv (PR) in dosegle kasnejši celotni klinični odziv (CCR), je bil 168 dni.
English: Percentages calculated as number of patients with responding lesions divided by total number of patients in the initial blinded phase.
Slovenian: Odstotek izračunan kot število bolnikov z odzivajočimi se lezijami, deljeno s skupnim številom bolnikov v začetni slepi fazi.
English: Very red, with oedema, with or without vesiculation
Slovenian: Zelo rdeče, z edemom, z ali brez mehurjenja
English: Do not cover the treated lesions with any bandage or other material.
Slovenian: Ne pokrivajte oskrbljene lezije s povojem ali drugim materialom.
English: DO NOT use Panretin if you are pregnant or thinking of becoming pregnant.
Slovenian: NE uporabljajte zdravila Panretin gel, če ste noseči ali če nameravate zanositi.
English: Your doctor will tell you how long your treatment will last.
Slovenian: Zdravnik vas bo seznanil s trajanjem zdravljenja.
English: The regulation of gene expression by alitretinoin controls the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Slovenian: Regulacija izražanja genov z alitretinoinom nadzoruje proces celične diferenciacije in proliferacije v tako normalnih kot tudi neoplastičnih celicah.
English: However, treatment should not be restarted if Grade 4 toxicity occurred at an application frequency of less than twice a day.
Slovenian: Zdravljenje pa se ne sme ponovno uvesti, če se je pojavila toksičnost stopnje 4 pri pogostosti nanosa manj kot dvakrat dnevno.
English: Store in the original container in order to protect from light.
Slovenian: Shranjujte v originalni ovojnini za zagotovitev zaščite pred svetlobo.
English: Treatment of lesions that have not shown a decrease in area and/or height by week 12 should be discontinued.
Slovenian: Zdravljenje lezij, ki se niso zmanjšale po površini oz. višini do 12. tedna, je treba prekiniti.
English: Do not use after the expiry date which is stated on the end of the tube.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na tubi.
English: The safety of Panretin gel has been assessed in clinical studies of more than 469 patients with AIDS-related KS, 439 of whom were treated with an alitretinoin concentration of 0.1%.
Slovenian: Varnost zdravila Panretin gel je bila ocenjena v kliničnih raziskavah z več kot 469 bolniki, obolelimi z AIDS povezanim KS, od katerih je bilo 439 zdravljenih z alitretinoinom v koncentraciji 0,1 %.
English: Do not use Panretin: - if you are allergic to alitretinoin or to similar medicines containing retinoids - if you are allergic to any of the other ingredients of this medicine (listed in section 6) - if you are pregnant - if you are planning a pregnancy - if you are breast-feeding - on KS lesions close to any other skin complaint
Slovenian: Ne uporabljajte zdravila Panretin - če ste alergični na alitretinoin ali podobna zdravila, ki vsebujejo retinoide, - če ste alergični na katero koli sestavino tega zdravila (navedeno v poglavju 6), - če ste noseči, - če načrtujete nosečnost, - če dojite, - za nanos na KS lezije, ki se nahajajo v neposredni bližini drugih obolenj kože.
English: If application site toxicity occurs, the application frequency can be reduced as described below.
Slovenian: Če se pojavi toksičnost na predelu nanosa, se lahko pogostost uporabe zmanjša tako kot je opisano spodaj.
English: Local dermal toxicity associated with Panretin gel therapy generally resolved with treatment adjustment or discontinuation (see section 4.2).
Slovenian: Lokalna dermalna toksičnost, ki je povezana s terapijo z zdravilom Panretin gel, je bila večinoma odpravljena s prilagoditvijo zdravljenja ali s prekinitvijo (glejte poglavje 4.2).
English: Wash your hands using soap and water and wipe the healthy skin touched by the gel.
Slovenian: Z milom in vodo si umijte roke ter obrišite zdravo kožo, ki je prišla v stik z gelom.
English: Increased redness, possible oedema
Slovenian: Povečana pordelost, morebitni edem
English: Duration of application
Slovenian: Trajanje uporabe
English: Alitretinoin (9-cis-retinoic acid), a naturally-occurring endogenous hormone related to vitamin A, binds to and activates all known intracellular retinoid receptor subtypes (RAR, RAR, RAR, RXR, RXR, RXR).
Slovenian: Alitretinoin (9-cis-retinoidna kislina), je naravno prisoten endogeni hormon, soroden z vitaminom A, ki se veže na in aktivira vse znane znotrajcelične podtipe retinoidne receptorje (RARα, RAR, RAR, RXRα, RXRβ, RXRγ).
English: Other medicines and Panretin
Slovenian: Druga zdravila in zdravilo Panretin
English: It is recommended that HIV-infected mothers do not breast-feed their children to exclude the risk of transmission of the virus.
Slovenian: Matere, ki so okužene z virusom HIV, naj ne dojijo svojih otrok, saj v nasprotnem primeru obstaja nevarnost prenosa virusa.
English: The frequency of application should be adjusted for each lesion independently.
Slovenian: Pogostost uporabe je treba določiti za vsako lezijo posebej.
English: There are no data on the efficacy of Panretin applied less frequently than twice daily.
Slovenian: Ni podatkov o učinkovitosti zdravila Panretin, če se ta nanaša manj kot dvakrat dnevno.
English: Patients should initially apply Panretin twice a day to cutaneous KS lesions.
Slovenian: Bolniki naj na začetku nanesejo zdravilo Panretin dvakrat dnevno na kožne KS lezije.
English: What Panretin is and what it is used for
Slovenian: Kaj je zdravilo Panretin in za kaj ga uporabljamo
English: If you forget to take Panretin
Slovenian: Če ste pozabili vzeti zdravilo Panretin
English: - lesions are not ulcerated or lymphoedematous - treatment of visceral KS is not required - lesions are not responding to systemic antiretroviral therapy - radiotherapy or chemotherapy are not appropriate
Slovenian: - lezije niso zagnojene in se niso razvili limfedemi, - zdravljenje visceralnega KS ni potrebno, - če se lezije ne odzovejo na sistemsko antiretrovirusno terapijo, - če radioterapija ali kemoterapija nista primerni.
English: For any information about this medicine please contact the local representative of the Marketing Authorisation Holder.
Slovenian: Za vse morebitne nadaljnje informacije o tem zdravilu se lahko obrnete na predstavništvo imetnika dovoljenja za promet z zdravilom.
English: Panretin is used in patients with AIDS-related Kaposi's sarcoma (KS) and is for the treatment of the KS lesions: - that are on the skin only - which have not responded to your HIV treatment - where the skin or lesion is not broken - where the surrounding skin is not swollen - if your doctor thinks that other treatments are not suitable for you.
Slovenian: Zdravilo Panretin se uporablja pri bolnikih s Kaposijevim sarkomom (KS), ki se pojavi zaradi AIDS Namenjen je zdravljenju KS lezij: - ki se nahajajo le na koži, - ki se niso odzvale na vaše HIV zdravljenje, - kjer koža oz. lezija ni počila, - kjer koža v okolici ni otekla in - če vaš zdravnik meni, da druge oblike zdravljenja za vas niso primerne.
English: This level is about 1/100 the mean concentration measured in male rats.
Slovenian: Ta raven predstavlja približno 1/100 srednje koncentracije, merjene pri podganjih samcih.
English: If the product is used during pregnancy, or if the patient becomes pregnant while taking this drug, treatment should be discontinued.
Slovenian: Če bolnica zdravilo uporablja med nosečnostjo ali če med jemanjem tega zdravila zanosi, je treba zdravljenje prekiniti.
English: If your side effects become too uncomfortable, with intense redness and irritation, rash, swelling, or pain, you should ask your doctor for advice on adjusting the dosage of your treatment.
Slovenian: Če stranski učinki postanejo zelo neprijetni, z intenzivno pordelostjo in draženjem kože, če se razvijejo izpuščaji, otekline ali bolečine, se obrnite na svojega zdravnika za nasvet glede odmerjanja zdravila za vaše zdravljenje.
English: Number of Responding
Slovenian: Število odzivov
English: In one trial, 29% of the lesions that had reached a partial response (PR) but had not attained clinical complete response (CCR) within the first 12 weeks of treatment developed a CCR during continuing treatment beyond 12 weeks.
Slovenian: V enem poskusu je 29 % lezij, ki so dosegle delni odziv (PR), ne pa celotnega kliničnega odziva (CCR) v času prvih 12 tednov zdravljenja, doseglo celotni klinični odziv (CCR) med podaljšanim zdravljenjem po 12 tednih.
English: Treatment of any lesion that has fully resolved on clinical assessment should be discontinued.
Slovenian: Prekiniti je treba zdravljenje lezij, ki so se po kliničnih ocenah v celoti odpravile.
English: Like all medicines, Panretin can have side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Panretin neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: However, the incidence of other equally common drug-related adverse events such as pruritus, oedema, exfoliative dermatitis and dry skin did not appear to increase as a function of the frequency of application.
Slovenian: Vendar pa se pojav drugih enako običajnih neželenih učinkov, ki so posledica uporabe zdravila, kot so npr. pruritus, edem, eksfoliativni dermatitis in suha koža, ni povečal kot posledica pogostosti aplikacije.
English: After opening, use within 90 days.
Slovenian: Po odprtju lahko zdravilo uporabljate največ 90 dni.
English: - Allow the gel to dry for three to five minutes before covering a treated area with loose clothing.
Slovenian: - Pustite gel sušiti tri do pet minut, preden zdravljene predele kože pokrijete z ohlapnim oblačilom.
English: Protocol-specified dose regimen was application twice a day (BD) only, with downward adjustments for toxicity.
Slovenian: S protokolom določeno odmerjanje je bila uporaba le dvakrat dnevno (BD), s prilagoditvijo navzdol pri toksičnosti.
English: Local dermal irritation may be graded according to the five-point scale shown in Table 1.
Slovenian: Lokalno draženje kože se lahko razvrsti po pet-točkovni lestvici, prikazani v razpredelnici 1.
English: - CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE IMPOSED ON THE MARKETING AUTHORISATION HOLDER
Slovenian: • POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE, PREDPISANI IMETNIKU DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: However, alitretinoin is teratogenic so both men and women should take adequate precautions to avoid female partners becoming pregnant.
Slovenian: Vendar pa je alitretinoin teratogen, zato morajo moški in ženske z ustreznimi zaščitnimi ukrepi pri ženski preprečiti nosečnost.
English: What you need to know before you use Panretin
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Panretin
English: 1 g of gel contains 1 mg of alitretinoin.
Slovenian: 1 g gela vsebuje 1 mg alitretinoina.
English: There was no clinical evidence in the vehicle-controlled studies of interactions with systemic antiretroviral agents, including protease inhibitors; macrolide antibiotics and azole antifungals.
Slovenian: Kliničnih izsledkov v nadzorovanih študijah medsebojnega delovanja zdravila s sistemskimi antiretrovirusnimi učinkovinami, kot so inhibitorji proteaze, makrolidni antibiotiki in azolni antimikotiki, ni bilo.
English: There are no data regarding the use of Panretin gel in patients with renal insufficiency or liver disease.
Slovenian: Ni podatkov glede uporabe zdravila Panretin gel pri bolnikih z ledvično insuficienco ali jetrno boleznijo.
English: Three doses of alitretinoin (0.01%, 0.05%, or 0.5%) in a topical gel formulation were given to rats in a 28-day dermal toxicology study.
Slovenian: Trije različni odmerki alitretinoina (0,01 %, 0,05 %, ali 0,5 %) v obliki gela za lokalno uporabo so bili dani podganam v študiji dermalne toksičnosti, ki je trajala 28 dni.
English: 1 g of gel contains 1 mg alitretinoin (0.1%).
Slovenian: 1 g gela vsebuje 1 mg alitretinoina (0,1 %).
English: Do not use a double dose to make up for forgotten individual doses.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnjega.
English: 2 = Moderate
Slovenian: 2 = Zmerno
English: Keep away from naked flame.
Slovenian: Ne približujte ga odprtemu plamenu.
English: After opening the tube for application, the tube cap must be replaced and closed tightly to provide an airtight seal.
Slovenian: Po odpiranju tube morate pokrovček tube ponovno namestiti ter tesno zapreti, tako da je tuba nepropustna za zrak.
English: When used in accordance with the prescribing information topically administered retinoids are generally assumed to result in low systemic exposure due to minimal dermal absorption.
Slovenian: Če retinoide za lokalno uporabo uporabljamo v skladu z informacijami za njihovo predpisovanje, se zanje v splošnem smatra, da zaradi minimalne absorbcije skozi kožo povzročajo nizko sistemsko izpostavljenost.
English: Deep red, swelling and oedema with or without signs of bullae formation and necrosis
Slovenian: Intenzivno rdeče, oteklina in edem z ali brez znakov nastajanja bul in nekroze
English: Protocol-specified dose regimen was application three times a day (TID) escalating to four times a day (QID) after two weeks, with downward adjustments for toxicity.
Slovenian: S protokolom določeno odmerjanje je bila uporaba trikrat dnevno (TID), ki se je stopnjevala do štirikrat dnevno (QID) po dveh tednih, s prilagoditvijo navzdol pri toksičnosti.
English: - Avoid prolonged exposure of the treated area to sunlight or other ultraviolet (UV) light (such as tanning lamps).
Slovenian: - Preprečite daljšo izpostavljenost zdravljenih delov kože sončni svetlobi ali drugi ultravijolični (UV) svetlobi (kot so npr. solariji).
English: Table 3 Adverse reactions reported in patients in clinical trials
Slovenian: Razpredelnica 3 Neželeni učinki, o katerih so poročali bolniki v kliničnih preskušanjih
English: In contrast to these findings in rats, plasma concentrations of 9-cis-retinoic acid in patients with KS applying Panretin gel never exceeded 0.638 ng/ml (2.13 nMol).
Slovenian: V nasprotju s temi spoznanji pri podganah, koncentracije 9-cis-retinoidne kisline v plazmi pri bolnikih s KS, ki so uporabljali zdravilo Panretin gel, nikoli niso presegle 0,638 ng/ml (2,13 nMol).
English: Overall Response %
Slovenian: Skupni odziv %
English: Treatment frequency for that lesion should be reduced or suspended.
Slovenian: Pogostost zdravljenja za to lezijo je treba zmanjšati ali zdravljenje v celoti ustaviti.
English: While no data are available, it is possible that co-administration of medicinal products which induce CYP isozymes may reduce circulating levels of alitretinoin, with a possible negative effect on the efficacy of Panretin gel.
Slovenian: Čeprav ni razpoložljivih podatkov, je možno, da sočasna uporaba zdravil, ki inducirajo CYP izoencime, zmanjša nivoje alitretinoina v plazmi, s posledičnim možnim negativnim vplivom na učinkovitost zdravila Panretin gel.
English: Showering, bathing, or swimming for at least three hours after any application should be avoided.
Slovenian: Prhanju, kopanju ali plavanju se je po nanosu potrebno izogniti za najmanj tri ure.
English: - Do not use insect repellents containing DEET (N,N-diethyl-m-toluamide) or other products containing DEET while using Panretin.
Slovenian: - Ne uporabljajte sredstev proti insektom, ki vsebujejo DEET (N,N-dietil-m-toluamid) ali drugih izdelkov, ki vsebujejo DEET v času uporabe zdravila Panretin gel.
English: If any of the side effects gets serious or if you notice any side effects not mentioned in this leaflet, please tell your doctor or pharmacist.
Slovenian: Če katerikoli neželeni učinek postane resen ali če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
English: Based on the plasma concentrations observed in patients, milk concentrations of 9-cis-retinoic acid probably pose a low risk for the infant.
Slovenian: Na osnovi koncentracij izmerjenih v plazmi bolnikov, predstavljajo verjetno koncentracije 9-cis-retinoidne kisline v materinem mleku le nizko tveganje za dojenčka.
English: Although the molecular action of alitretinoin is thought to be mediated through interaction with the retinoid receptors, the exact mechanism of action of this medicinal product in the topical treatment of cutaneous lesions of AIDS-related KS is unknown.
Slovenian: Čeprav se za molekularno delovanje alitretinoina misli, da je posredovano z njegovim medsebojnim delovanjem z retnoidnimi receptorji, natančni mehanizem delovanja tega zdravila pri lokalnem zdravljenju kožnih lezij, ki nastanejo zaradi z AIDS povezanim KS ni znan.
English: However, because of the potential for undesirable effects from Panretin gel in infants being breast-fed, mothers must discontinue breast-feeding prior to using the medicinal product and not initiate breast-feeding while using the medicinal product.
Slovenian: Vendar pa morajo matere zaradi možnosti neželenih učinkov pri dojenih otrocih, ki bi bili posledica uporabe zdravila Panretin gel, pred uporabo tega zdravila prenehati z dojenjem oz. ne smejo začeti z dojenjem v času uporabe tega zdravila.
English: Panretin gel should not be used concurrently with products containing DEET.
Slovenian: Zdravilo Panretin gel se ne sme uporabiti sočasno z izdelki, ki vsebujejo DEET.
English: The safety and efficacy of Panretin gel in children under 18 years has not been established.
Slovenian: Varnost in učinkovitost zdravila Panretin gel pri otrocih, starih do 18 let, še nista bili dokazani.
English: Panretin therapy should only be initiated and maintained by specialist physicians experienced in the treatment of patients with KS.
Slovenian: Terapijo z zdravilom Panretin naj predpiše in nadzoruje le zdravnik specialist, ki ima izkušnje z zdravljenjem bolnikov s KS.
English: Guidelines for treatment adjustments necessitated by local dermal treatment-related toxicity are specified in Table 2.
Slovenian: Smernice za prilagoditev zdravljenja zaradi z zdravljenjem povezane lokalne toksičnosti, so specificirane v razpredelnici 2.
English: When applying Panretin gel, 69.1% of patients experienced adverse drug reactions at the application site.
Slovenian: Pri uporabi zdravila Panretin gel je 69,1 % bolnikov opazilo neželene učinke zdravila na mestu nanosa.
English: Contains alcohol, keep away from naked flame.
Slovenian: Vsebuje alkohol, zavarujte pred odprtim ognjem.
English: The results suggest that alitretinoin absorbs light in the UV range and is subject to photodegradation to other isomers (predominantly all-trans-retinoic acid).
Slovenian: Na osnovi rezultatov je verjetno, da alitretinoin absorbira svetlobo na UV področju ter da je podvržen fotodegradaciji drugih izomerov (predvsem trans-retinoidne kisline).
English: Take special care with Panretin - Panretin is not approved for use in children and adolescents under 18 years of age.
Slovenian: Bodite posebno pozorni pri uporabi zdravila Panretin - Uporaba zdravila Panretin pri otrocih in mladostnikih, starih manj kot 18 let, ni odobrena.
English: It is recommended that Panretin gel should be applied for an initial treatment period of up to 12 weeks.
Slovenian: Priporočamo, da se zdravilo Panretin gel uporablja za začetno fazo zdravljenja, ki traja do 12 tednov.
English: Clinical pathology evaluations revealed significant increases in absolute polymorphonuclear leukocyte counts, monocyte counts, percentage of monocytes and decreases in percentage of lymphocyte differential white blood cell counts on day 29 of rats treated with alitretinoin 0.5% gel.
Slovenian: Analize klinične patologije so pokazale občutno povečanje absolutnega števila polimorfonuklearnih levkocitov, števila monocitov, odstotek monocitov ter upadanje odstotka limfocidov v diferencialni krvni sliki belih krvnih telesc na 29. dan, in sicer pri podganah, ki so jih zdravili z 0,5 % alitretinoinovim gelom.
English: Frequency of application
Slovenian: Pogostost uporabe
English: Avoid the use of other products on your treated KS lesions such as insect repellents that you use on your skin.
Slovenian: Izogibajte se uporabi drugih izdelkov na zdravljenih KS lezijah, kot so sredstva za odvračanje insektov (repelenti), ki se nanesejo na kožo.
English: It is recommended that Panretin should be applied to lesions for an initial period of up to 12 weeks.
Slovenian: Priporočamo, da se zdravilo Panretin nanaša na lezije v začetnem obdobju, ki traja do 12 tednov.
English: Table 5 provides the individual lesion response rates for patients being treated with Panretin gel in the Phase III studies.
Slovenian: V razpredelnici 5 so posredovane posamezne stopnje odziva bolnikov, ki so se zdravili z zdravilom Panretin gel v fazi III.
English: Pale skin
Slovenian: Bledica kože