FrancophonIA/ELRC3.0 huggingface dataset:
English: - determine how much LUSDUNA per day you will need and at what time, - tell you when to check your blood sugar level, and whether you need to carry out urine tests, - tell you when you may need to inject a higher or lower dose of LUSDUNA.
Slovenian: - določil, koliko zdravila LUSDUNA na dan boste potrebovali in ob katerem času, - povedal, kdaj morate izmeriti krvni sladkor in ali morate opravljati teste urina, - povedal, kdaj boste morda morali zvečati ali zmanjšati odmerek zdravila LUSDUNA.
English: Mixing or diluting can change its time/action profile and mixing can cause precipitation.
Slovenian: Mešanje ali redčenje lahko spremeni profil časovnega poteka/delovanja; mešanje lahko povzroči precipitacijo.
English: Is the insulin clear, colourless and free of particles?
Slovenian: Je insulin bister, brezbarven in brez delcev?
English: If normal or decreased values for glycated haemoglobin are noted, the possibility of recurrent, unrecognised (especially nocturnal) episodes of hypoglycaemia must be considered.
Slovenian: V primeru normalnih ali znižanih vrednosti glikoziliranega hemoglobina je treba pomisliti na možnost ponavljajočih se, neprepoznanih (zlasti nočnih) hipoglikemij.
English: Intercurrent illness requires intensified metabolic monitoring.
Slovenian: V primeru sočasnih bolezni je potreben intenzivnejši nadzor metabolne presnove.
English: Follow closely the instructions for posology, monitoring (blood and urine tests), diet and physical activity (physical work and exercise), injection technique as discussed with your doctor.
Slovenian: Natančno upoštevajte navodila za odmerjanje, nadzorovanje bolezni (preiskave krvi in urina), prehrano in telesno aktivnost (fizično delo in telovadbo) ter postopek injiciranja, kot ste se dogovorili z zdravnikom.
English: Clinical study safety data are not available for children under 2 years.
Slovenian: Podatkov o varnosti iz kliničnih študij pri otrocih, mlajših od 2 let, ni na voljo.
English: If you need to inject more than the number of units left in the pen, you may either: - inject the amount left in your pen and then use a new pen to give the rest of your dose, or - get a new pen and inject the full dose.
Slovenian: Če morate injicirati več enot, kot jih je v injekcijskem peresniku, lahko: - injicirajte količino, ki je še ostala v injekcijskem peresniku, nato pa uporabite nov peresnik, da boste injicirali še preostanek odmerka, ali - vzemite novi injekcijski peresnik in z njim injicirajte celoten odmerek.
English: Count to 10 slowly after you see 0 and the green stripe.
Slovenian: Potem, ko zagledate 0 in zeleno črto, počasi preštejte do 10.
English: Severe hypoglycaemic attacks, especially if recurrent, may lead to neurological damage.
Slovenian: Hude hipoglikemije, zlasti ponavljajoče se, lahko povzročijo nevrološke okvare.
English: Do not use LUSDUNA - If you are allergic to insulin glargine or any of the other ingredients of this medicine (listed in
Slovenian: Ne uporabljajte zdravila LUSDUNA - če ste alergični na insulin glargin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: These units are exclusive to insulin glargine and are not the same as IU or the units used to express the potency of other insulin analogues (see section 5.1).
Slovenian: Te enote veljajo izključno za insulin glargin in niso enake mednarodnim enotam (i.e.) ali enotam, ki se uporabljajo za izražanje moči drugih insulinskih analogov (glejte poglavje 5.1).
English: This should be kept in mind if treatment with the combination of pioglitazone and LUSDUNA is considered.
Slovenian: To je treba upoštevati pri odločitvi glede zdravljenja s kombinacijo pioglitazona in zdravila LUSDUNA.
English: Continuous rotation of the injection site within the given injection area may help to reduce or prevent these reactions.
Slovenian: Stalna menjava mest injiciranja na posameznem predelu za injiciranje pomaga zmanjšati ali preprečiti te reakcije.
English: Patients should be advised to take precautions to avoid hypoglycaemia whilst driving.
Slovenian: Bolnikom je treba naročiti, naj upoštevajo previdnostne ukrepe za preprečitev hipoglikemije med vožnjo.
English: If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and oedema.
Slovenian: V primeru uporabe kombinacije je treba bolnike spremljati glede znakov in simptomov srčnega popuščanja, povečevanja telesne mase in edemov.
English: Only use needles that are compatible for use with Nexvue (see “Nexvue Instructions for Use”).
Slovenian: Uporabljajte le igle, ki so združljive s peresnikom Nexvue (glejte "Navodila za uporabo injekcijskega peresnika Nexvue").
English: Changes in strength, brand (manufacturer), type (regular, NPH, lente, long-acting, etc.), origin (animal, human, human insulin analogue) and/or method of manufacture may result in the need for a change in dose.
Slovenian: Spremembe jakosti, znamke (izdelovalca), vrste (običajni, NPH, lente, dolgodelujoči, itd.), izvora (živalski, humani, analog humanega insulina) in/ali načina izdelave lahko zahtevajo spremembo odmerka.
English: What you need to know before you use LUSDUNA
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo LUSDUNA
English: Over the course of this 6-year study, 42 % of the insulin glargine group did not experience any hypoglycaemia.
Slovenian: Med to 6-letno študijo 42 % bolnikov v skupini z insulinom glargin ni imelo nobene hipoglikemije.
English: LUSDUNA is not the insulin of choice for the treatment of diabetic ketoacidosis.
Slovenian: Zdravilo LUSDUNA ni insulin prve izbire za zdravljenje diabetične ketoacidoze.
English: Your insulin dose may need to be changed during pregnancy and after giving birth.
Slovenian: Odmerek insulina bo med nosečnostjo in po porodu morda potrebno spremeniti.
English: A large amount of data on pregnant women (more than 1,000 pregnancy outcomes) indicate no specific adverse effects of insulin glargine on pregnancy and no specific malformative nor foeto/neonatal toxicity of insulin glargine.
Slovenian: Velika količina podatkov o nosečnicah (več kot 1.000 izidov nosečnosti) ne kaže specifičnih neželenih učinkov insulina glargin na nosečnost in ne kaže nobenih specifičnih malformacij ali fetotoksičnih učinkov/toksičnih učinkov na novorojenčka.
English: QR code linking to the instructions for use to be included.
Slovenian: Vstaviti je treba QR-kodo s povezavo na navodila za uporabo.
English: What LUSDUNA is and what it is used for
Slovenian: Kaj je zdravilo LUSDUNA in za kaj ga uporabljamo
English: For insulin glargine no clinical data on exposed pregnancies from controlled clinical studies are available.
Slovenian: Za insulin glargin iz kontroliranih kliničnih študij ni na voljo kliničnih podatkov o nosečnicah, ki so bile izpostavljene zdravilu.
English: Check the dose window...
Slovenian: Preverite okence odmerka ...
English: You should contact your doctor for advice on driving if: - you have frequent episodes of hypoglycaemia, - the first warning symptoms which help you to recognise hypoglycaemia are reduced or absent.
Slovenian: Glede upravljanja vozil se morate posvetovati z zdravnikom: - če imate pogoste hipoglikemije, - če se prvi opozorilni znaki, ki vam pomagajo prepoznati hipoglikemijo, zmanjšajo ali jih nimate.
English: Select the dose
Slovenian: Izberite odmerek
English: In general, the side effects in children and adolescents of 18 years of age or less are similar to those seen in adults.
Slovenian: Na splošno so neželeni učinki pri otrocih in mladostnikih, starih 18 let ali manj, podobni kot pri odraslih.
English: Since LUSDUNA is a solution, it does not require resuspension before use.
Slovenian: Zdravilo LUSDUNA je raztopina, zato pred uporabo ne potrebuje resuspendiranja.
English: Rarely, insulin may cause sodium retention and oedema particularly if previously poor metabolic control is improved by intensified insulin therapy.
Slovenian: Redko lahko insulin povzroči zadrževanje natrija in edeme, zlasti, če se predhodno slaba metabolna presnovna urejenost z intenziviranim insulinskim zdravljenjem izboljša.
English: Do not use Nexvue if it is damaged or not working properly; it has to be discarded and a new pen has to be used.
Slovenian: Injekcijskega peresnika Nexvue ne uporabite, če je poškodovan ali ne deluje pravilno; injekcijski peresnik morate zavreči in uporabiti novega.
English: Insulin treatment can cause the body to produce antibodies to insulin (substances that act against insulin).
Slovenian: Zdravljenje z insulinom lahko povzroči, da telo začne tvoriti protitelesa proti insulinu (snovi, ki delujejo proti insulinu).
English: Counting to 10 allows time for all of the insulin to come out of the pen, making sure that you get your full dose.
Slovenian: Štetje do 10 omogoči čas, da iz injekcijskega peresnika pride ves insulin in da boste prejeli celotni odmerek.
English: However, only very rarely, this will require a change to your insulin dose.
Slovenian: Vendar pa bo to samo v zelo redkih primerih zahtevalo spremembo odmerka insulina.
English: A marked change (improvement or worsening) in your blood sugar control can disturb your vision temporarily.
Slovenian: Izrazita sprememba (izboljšanje ali poslabšanje) urejenosti krvnega sladkorja lahko povzroči prehodne motnje vida.
English: Make sure that neither alcohol nor other disinfectants or other substances contaminate the insulin.
Slovenian: Poskrbite, da insulina ne bodo onesnažili alkohol, druga dezinfekcijska sredstva ali kakšne druge snovi.
English: A. MANUFACTURER(S) OF THE BIOLOGICAL ACTIVE SUBSTANCE(S) AND MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALEC (IZDELOVALCI) BIOLOŠKE UČINKOVINE (UČINKOVIN) IN IZDELOVALEC (IZDELOVALCI) ODGOVOREN (ODGOVORNI) ZA SPROŠČANJE SERIJ
English: If you haven't been trained before, ask your doctor or nurse to show you how to use your pen.
Slovenian: Če se še niste usposobili, prosite zdravnika ali medicinsko sestro, naj vam pokažeta, kako uporabljati
English: Inform your doctor as soon as possible if you experience signs of heart failure such as unusual shortness of breath or rapid increase in weight or localised swelling (oedema).
Slovenian: Nemudoma obvestite zdravnika, če se pri vas pojavijo znaki srčnega popuščanja, kot so neobičajna kratka sapa, naglo povečanje telesne mase ali lokalizirano otekanje (edemi).
English: This helps make sure you get your full dose of insulin.
Slovenian: To pomaga zagotoviti, da boste prejeli celotni odmerek insulina.
English: Most minor reactions to insulins at the injection site usually resolve in a few days to a few weeks.
Slovenian: Večina manjših reakcij na insuline na mestu injiciranja po navadi izzveni v nekaj dneh do nekaj tednih.
English: Prepare for your injection
Slovenian: Pripravite se za injiciranje
English: • Eye reactions
Slovenian: • Očesne reakcije
English: Pentamidine (used to treat some infections caused by parasites) may cause hypoglycaemia which may sometimes be followed by hyperglycaemia.
Slovenian: Pentamidin (uporablja se za zdravljenje nekaterih okužb, ki jih povzročijo paraziti) lahko povzroči hipoglikemijo, ki ji včasih sledi hiperglikemija.
English: What LUSDUNA is and what it is used for What you need to know before you use LUSDUNA
Slovenian: Kaj je zdravilo LUSDUNA in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo LUSDUNA
English: If your pen is in cool storage, take it out 1 to 2 hours before you inject to allow it to warm up.
Slovenian: Če je injekcijski peresnik shranjen v hladnem prostoru, ga vzemite ven 1 do 2 uri pred injiciranjem, da se ogreje.
English: Before taking a medicine ask your doctor if it can affect your blood sugar level and what action, if any, you need to take.
Slovenian: Pred jemanjem zdravila zdravnika vprašajte, ali zdravilo lahko vpliva na koncentracijo krvnega sladkorja ter ali je v zvezi s tem potrebno kakšno posebno ravnanje, in če, kakšno.
English: In patients with type 2 diabetes mellitus, LUSDUNA can also be given together with oral antidiabetic medicinal products.
Slovenian: Pri bolnikih s sladkorno boleznijo tipa 2 se zdravilo LUSDUNA lahko uporablja skupaj s peroralnimi antidiabetiki.
English: Don't use your pen if it has been removed from the refrigerator for more than 28 days.
Slovenian: Injekcijskega peresnika ne uporabljajte, če ste ga iz hladilnika vzeli pred več kot 28 dnevi.
English: The patient's ability to concentrate and react may be impaired as a result of hypoglycaemia or hyperglycaemia or, for example, as a result of visual impairment.
Slovenian: Bolnikova zmožnost koncentracije in reagiranja se lahko poslabša zaradi hipoglikemije ali hiperglikemije ali npr. zaradi okvare vida.
English: You may need to talk about: - the availability of your insulin in the country you are visiting, - supplies of insulin, syringes etc., - correct storage of your insulin while travelling, - timing of meals and insulin administration while travelling, - the possible effects of changing to different time zones, - possible new health risks in the countries to be visited, - what you should do in emergency situations when you feel unwell or become ill.
Slovenian: Med drugim se boste morali z njim pogovoriti o: - razpoložljivosti svojega insulina v državi, v katero se odpravljate, - zalogah insulina, injekcijskih brizg itd., - pravilnem shranjevanju insulina med potovanjem, - časovnem razporedu obrokov in dajanja insulina na potovanju, - možnih vplivih spremembe časovnih pasov, - možnih novih zdravstvenih tveganjih v državah, ki jih boste obiskali, - ukrepih v nujnih primerih, če se ne počutite dobro ali zbolite.
English: • Do not put it back in the refrigerator or freeze.
Slovenian: • Ne dajajte ga nazaj v hladilnik in ga ne zamrznite.
English: Deliver the dose by pressing the injection button until you see 0 and a green stripe appears in the window.
Slovenian: Odmerek injicirajte tako, da pritiskate gumb za injiciranje, dokler ne zagledate 0 in se v okencu pokaže zelena črta.
English: OUTER CARTON (with blue box) multipack - 10 (2 x 5)
Slovenian: ZUNANJA ŠKATLA (z modrim okencem) multi pakiranje - 10 (2 x 5)
English: Check the cartridge to make sure the insulin is clear, colourless and free of particles.
Slovenian: Preverite vložek in se prepričajte, da je insulin bister, brezbarven in brez delcev.
English: Mean dose of insulin glargine by study end was 0.42 U/kg.
Slovenian: Povprečni odmerek insulina glargin je bil na koncu študije 0,42 enot/kg.
English: The Nexvue pen delivers LUSDUNA in increments of 1 unit up to a maximum single dose of 60 units.
Slovenian: Injekcijski peresnik Nexvue omogoča povečevanje odmerkov zdravila LUSDUNA po 1 enoto do največjega enkratnega odmerka 60 enot.
English: This medicinal product contains less than 1 mmol (23 mg) sodium per dose, i.e., essentially “sodium-free”.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni "brez natrija".
English: Insulin glargine did not alter the relative risk for CV disease and CV mortality when compared to standard of care.
Slovenian: Insulin glargin v primerjavi s standardnim zdravljenjem ni spremenil relativnega tveganja za CV bolezni ali CV umrljivost.
English: It is advisable to test your blood sugar immediately after taking glucose to check that you really have hypoglycaemia.
Slovenian: Takoj po zaužitju glukoze je priporočljivo izmeriti krvni sladkor, da preverite, ali gre res za hipoglikemijo.
English: There were no differences between insulin glargine and standard care for the two co-primary outcomes; for any component endpoint comprising these outcomes; for all-cause mortality; or for the composite microvascular outcome.
Slovenian: Med insulinom glargin in standardnim zdravljenjem ni bilo razlik glede obeh soprimarnih izidov, glede nobene komponente opazovanega dogodka, ki je obsegal te izide, glede umrljivosti zaradi vseh vzrokov ali glede sestavljenega mikrovaskularnega izida.
English: Every time you inject you need to do a small test dose to make sure your pen is working.
Slovenian: Pred vsakim injiciranjem morate opraviti preizkus z majhnim testnim odmerkom, da se prepričate, če injekcijski peresnik deluje.
English: LUSDUNA and medicinal products containing insulin glargine 300 units/mL are not bioequivalent and are not directly interchangeable.
Slovenian: Zdravilo LUSDUNA in zdravila, ki vsebujejo insulin glargin 300 enot/ml, niso bioekvivalentna in niso neposredno medsebojno zamenljiva.
English: Pens in use must not be stored in the refrigerator.
Slovenian: Injekcijskih peresnikov, ki so v uporabi, se ne sme shranjevati v hladilniku.
English: Insulin overdose may lead to severe and sometimes long-term and life-threatening hypoglycaemia.
Slovenian: Preveliko odmerjanje insulina lahko povzroči hudo ter včasih dolgotrajno in življenjsko nevarno hipoglikemijo.
English: Before first use, the pen must be stored at room temperature for 1 to 2 hours to allow it to warm up.
Slovenian: Pred prvo uporabo mora biti injekcijski peresnik 1 do 2 uri na sobni temperaturi, da se segreje.
English: Press to inject into the air
Slovenian: Pritisnite, da boste injicirali v zrak
English: Factors increasing the susceptibility to hypoglycaemia require particularly close monitoring and may necessitate dose adjustment.
Slovenian: V primeru dejavnikov, ki povečujejo dovzetnost za hipoglikemijo, je potrebno posebno skrbno spremljanje in morda prilagoditev odmerka.
English: Pre-filled pens in use or carried as a spare may be stored for a maximum of 28 days up to 30°C and away from direct heat and direct light.
Slovenian: Napolnjene injekcijske peresnike, ki jih uporabljate ali nosite s seboj za rezervo, lahko shranjujete največ 28 dni pri temperaturi do 30 °C in zaščitene pred neposredno vročino in svetlobo.
English: Thirst, increased need to urinate, tiredness, dry skin, reddening of the face, loss of appetite, low blood pressure, fast heartbeat, and glucose and ketone bodies in urine.
Slovenian: Žeja, pogostejša potreba po uriniranju, utrujenost, suha koža, pordelost obraza, izguba apetita, nizek krvni tlak, hitro bitje srca ter prisotnost glukoze in ketonskih teles v urinu.
English: Generally, the greater and more rapid the decline in blood glucose, the more marked is the phenomenon of counter-regulation and its symptoms (see section 4.4).
Slovenian: Praviloma so pojav protiregulacije in njegovi simptomi toliko izrazitejši, kolikor večje in hitrejše je znižanje koncentracije glukoze v krvi (glejte poglavje 4.4).
English: Severe allergic reactions (rare, may affect up to 1 in 1,000 people) - the signs may include largescale skin reactions (rash and itching all over the body), severe swelling of skin or mucous membranes (angioedema), shortness of breath, a fall in blood pressure with rapid heartbeat and sweating.
Slovenian: Hude alergijske reakcije (redke, pojavijo se lahko pri največ 1 od 1.000 bolnikov) - znaki lahko vključujejo obsežne kožne reakcije (izpuščaj in srbenje po celem telesu), hudo oteklost kože ali sluznic (angioedem), kratko sapo, padec krvnega tlaka s hitrim bitjem srca in znojenje.
English: Always check you have the right pen.
Slovenian: Vedno preverite, da imate pravi injekcijski peresnik.
English: Such reactions to insulin (including insulin glargine) or the excipients may, for example, be associated with generalised skin reactions, angio-oedema, bronchospasm, hypotension and shock, and may be life-threatening.
Slovenian: Takšne reakcije na insulin (tudi na insulin glargin) ali pomožne snovi so lahko na primer povezane z generaliziranimi kožnimi reakcijami, angioedemom, bronhospazmom, hipotenzijo in šokom, ter so lahko življenjsko nevarne.
English: Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.
Slovenian: Insulin in njegovi analogi zmanjšajo koncentracijo glukoze v krvi s spodbujanjem perifernega privzema glukoze, zlasti v skeletnih mišicah in maščevju, in z zaviranjem nastajanja glukoze v jetrih.
English: Empty pens must never be reused and must be properly discarded.
Slovenian: Praznih injekcijskih peresnikov se ne sme nikoli ponovno uporabiti in jih je treba ustrezno zavreči.
English: Pharmacotherapeutic group: Drugs used in diabetes, insulins and analogues for injection, long-acting.
Slovenian: Farmakoterapevtska skupina: zdravila za zdravljenje diabetesa, insulini za injiciranje z dolgotrajnim delovanjem in analogi.
English: Empty pens must not be re-filled and must be properly discarded.
Slovenian: Praznih peresnikov se ne sme ponovno polniti in jih je treba ustrezno zavreči.
English: Important information about some of the ingredients of LUSDUNA This medicine contains less than 1 mmol (23 mg) sodium per dose, i.e. it is essentially ‘sodium-free'.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila LUSDUNA To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni "brez natrija".
English: Hypoglycaemia (very common), in general the most frequent adverse reaction of insulin therapy, may occur if the insulin dose is too high in relation to the insulin requirement (see section 4.4).
Slovenian: Hipoglikemija (zelo pogosta), na splošno najpogostejši neželeni učinek pri zdravljenju z insulinom, se lahko pojavi, če je odmerek insulina prevelik glede na potrebo po insulinu (glejte poglavje 4.4).
English: One hundred forty three of the patients treated with insulin glargine in this study continued treatment with insulin glargine in an uncontrolled extension study with mean duration of follow-up of 2 years.
Slovenian: Stotriinštirideset bolnikov, ki so v tej študiji prejemali insulin glargin, je zdravljenje z njim nadaljevalo v nekontrolirani podaljšani študiji, v kateri je povprečno spremljanje trajalo 2 leti.
English: INTERMEDIATE CARTON (without blue box) component of a multipack - 5 pens
Slovenian: VMESNA ŠKATLA (brez modrega okenca) del multi pakiranja - 5 peresnikov
English: In clinical studies, subgroup analyses based on age and gender did not indicate any difference in safety and efficacy in insulin glargine-treated patients compared to the entire study population.
Slovenian: Analize podskupin po starosti in spolu v kliničnih študijah niso pokazale razlik glede varnosti in učinkovitosti pri bolnikih, zdravljenih z insulinom glargin, v primerjavi s celotno raziskovano populacijo.
English: If you have proliferative retinopathy (an eye disease related to diabetes) severe hypoglycaemic attacks may cause temporary loss of vision.
Slovenian: Če imate proliferativno retinopatijo (očesno bolezen, povezano s sladkorno boleznijo), lahko hude hipoglikemije povzročijo prehodno izgubo vida.
English: Other medicines and LUSDUNA
Slovenian: Druga zdravila in zdravilo LUSDUNA
English: In such a case, you may develop severe hypoglycaemia (and even faint) before you are aware of the problem.
Slovenian: V takšnem primeru se lahko pojavi huda hipoglikemija (in celo nezavest), še preden se sploh zaveste, da je kaj narobe.
English: After the injection Be careful not to stick your finger with the needle.
Slovenian: Po injiciranju Pazite, da se z iglo ne zbodete v prste.
English: The primary aim of demonstrating non-inferiority of insulin glargine to NPH in all hypoglycaemia was not met and there was a trend to an increase of hypoglycaemic events with insulin glargine [insulin glargine: NPH rate ratio (95 % CI) = 1.18 (0.97-1.44)].
Slovenian: Primarni cilj, dokazati neinferiornost insulina glargin v primerjavi z insulinom NPH pri vseh hipoglikemijah, ni bil dosežen in opazen je bil trend povečanja hipoglikemičnih dogodkov z insulinom glargin [razmerje deležev insulin glargin:NPH (95 % IZ) = 1,18 (0,97-1,44)].
English: OUTER CARTON - Packs of 1 and 5
Slovenian: ZUNANJA ŠKATLA - pakiranja po 1 in po 5
English: If you inject your insulin too often at the same skin site, fatty tissue under the skin at this site may either shrink (lipoatrophy, may affect up to 1 in 100 people) or thicken (lipohypertrophy).
Slovenian: Če si insulin prepogosto injicirate na isto mesto, se podkožno maščevje na tem mestu lahko skrči (lipoatrofija, pojavi se lahko pri največ 1 od 100 bolnikov) ali zadebeli (lipohipertrofija).