FrancophonIA/ELRC3.0 huggingface dataset:
English: In placebo controlled clinical trials of adult patients quetiapine was associated with an increased incidence of extrapyramidal symptoms (EPS) compared to placebo in patients treated for major depressive episodes in bipolar disorder(see sections 4.8 and 5.1).
Maltese: Fi provi kliniċi kkontrollati bi plaċebo f'pazjenti adulti quetiapine kien assoċjat ma' żieda fl-inċidenza ta' sintomi ekstrapiramidali (EPS) meta mqabbla ma' plaċebo f'pazjenti li kienu qed jirċievu kura għal episodji depressivi maġġuri f'disturbi bipolari (ara sezzjonijiet 4.8 u 5.1).
English: Coating
Maltese: Nekroliżi
English: In a clinical trial to evaluate the cataractogenic potential of Seroquel (200-800 mg/day) versus risperidone (2-8 mg/day) in patients with schizophrenia or schizoaffective disorder, the percentage of patients with increased lens opacity grade was not higher in Seroquel (4%) compared with risperidone (10%), for patients with at least 21 months of exposure.
Maltese: Fi prova klinika biex jiġi vvalutat il-potenzjal katarrettoġeniku ta' Seroquel (200-800 mg/kuljum) kontra risperidone (2-8 mg) f'pazjenti bi skizofrenija jew disturb skiżoaffettiv, il-persentaġġ ta' pazjenti b'żieda fil-grad tal-opaċità tal-lenti ma kienx ogħla f'Seroquel (4%) meta mqabbla ma' risperidone (10%), għal pazjenti li kellhom espożizzjoni ta' anqas minn 21 xahar.
English: Physostigmine may be used if there are no ECG aberrations.
Maltese: Physostigmine jista' jintuża jekk ma jkunx hemm aberrazzjonijiet fuq l-ECG.
English: Elderly patients with dementia-related psychosis Quetiapine is not approved for the treatment of dementia-related psychosis.
Maltese: Pazjenti anzjani bi psikożi relatata mad-dimenzja Quetiapine mhuwiex approvat għall-kura ta' psikożi relatata mad-dimenzja.
English: The recommended daily dose is 300 mg.
Maltese: Id-doża rakkomandata ta' kuljum hija ta' 300 mg.
English: 400 mg of quetiapine (as quetiapine fumarate).
Maltese: Kull pillola fiha 400 mg ta' quetiapine (bħala fumarate)
English: Seroquel 25 mg film-coated tablets Seroquel 100 mg film-coated tablets Seroquel 150 mg film-coated tablets Seroquel 200 mg film-coated tablets Seroquel 300 mg film-coated tablets Seroquel 3-Day Starterpack (Combined pack) Seroquel 4-Day Starterpack
Maltese: Seroquel 25 mg pilloli miksijin b'rita Seroquel 100 mg pilloli miksijin b'rita Seroquel 150 mg miksijin b'rita Seroquel 200 mg pilloli miksijin b'ritad Seroquel 300 mg pilloli miksijin b'rita Seroquel Pakkett tal-Bidu ta' 3 ijiem (Pakkett Ikkombinat) Seroquel Pakkett tal-Bidu ta' 4 ijiem
English: Neither low dose (400 mg/day) nor high dose regimen (800 mg/day) quetiapine was superior to placebo with respect to the percentage of patients achieving response, defined as ≥30% reduction from baseline in PANSS total score.
Maltese: La r-reġimen bid-doża l-baxxa (400 mg/kuljum) u l-anqas dak bid-doża l-għolja (800 mg/kuljum) ta' quetiapine ma' kien superjuri għal plaċebo fir-rigward tal-persentaġġ ta' pazjenti li kisbu rispons, definit bħala tnaqqis ta' ≥30% mil-linja bażi fil-punteġġ totali fuq PANSS.
English: Each tablet contains 300 mg quetiapine (as fumarate)
Maltese: Kull pillola fiha 300 mg ta' quetiapine (bħala fumarate)
English: The usual effective dose is in the range of 400 to 800 mg/day.
Maltese: Id-doża effettiva tas-soltu hija fil-medda ta' 500 sa 800 mg/kuljum.
English: INFORMATION IN BRAILLE Seroquel XR 300 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Seroquel XR 300 mg
English: Thrombocytope nia, Anaemia, platelet count decreased13
Maltese: Stitikezza, dispepsja, rimettar25
English: Among post marketing reports, while not all cases were confounded by risk factors, many patients had factors which are known to be associated with pancreatitis such as increased triglycerides (see section 4.4), gallstones, and alcohol consumption.
Maltese: Fost irrapporti ta' wara t-tqegħid fis-suq, filwaqt li mhux il-każijiet kollha kienu mfixkla minn fatturi ta' riskju, ħafna pazjenti kellhom fatturi li huma magħrufa li huma assoċjati ma' pankreatite bħal żieda fit-trigliċeridi (ara sezzjoni 4.4), ġebel fil-marrara, u konsum ta' alkoħol.
English: A retrospective study of children and adolescents who received valproate, quetiapine, or both, found a higher incidence of leucopenia and neutropenia in the combination group versus the monotherapy groups
Maltese: Studju retrospettiv ta' tfal u adolexxenti li rċevew valproate, quetiapine, jew it-tnejn, sab inċidenza ogħla ta' lewkopenja u newtropenja fil-grupp tal-kombinazzjoni kontra l-gruppi ta' monoterapija
English: There are no data from long-term studies to demonstrate Seroquel's effectiveness in preventing subsequent manic or depressive episodes.
Maltese: M'hemm ebda dejta minn studji fit-tul li turi l-effikaċja ta' Seroquel fil-prevenzjoni ta' episodji manijaċi jew depressivi sussegwenti.
English: Seroquel 150 mg contains 150 mg quetiapine (as quetiapine fumarate) Excipient : 29 mg lactose (anhydrous) per tablet
Maltese: Seroquel 150 mg fih 150 mg ta' quetiapine (bħala quetiapine fumarate)
English: Seroquel XR tablets contain lactose.
Maltese: Il-pilloli Seroquel XR fihom il-lattosju.
English: Decreased haemoglobin
Maltese: Tnaqqis flemoglobina
English: There have been reports of false positive results in enzyme immunoassays for methadone and tricyclic antidepressants in patients who have taken quetiapine.
Maltese: Kien hemm rapporti ta' riżultati pożittivi meta fil-fatt kienu negattivi f'immunoassaġġi tal-enzimi għal methadone u antidipressanti triċikliċi f'pazjenti li kienu ħadu quetiapine.
English: Seroquel Depot United Kingdom Seroquel XL
Maltese: Jekk iva, Seroquel XR
English: Pharmacokinetic data were sampled in 9 children aged 10-12 years old and 12 adolescents, who were on steady-state treatment with 400 mg quetiapine (Seroquel) twice daily.
Maltese: Dejta farmakokinetika ittieħdet bħala kampjun f'9 itfal bejn l-10-12-il sena u 12-il adolexxenti, li kienu fuq kura fi stat fiss b'400 mg ta' quetiapine (Seroquel) darbtejn kuljum.
English: Treatment with Seroquel was initiated at 50 mg/day and on day 2 increased to 100 mg/day; subsequently the dose was titrated to a target dose (mania 400-600 mg/day; schizophrenia 400-800 mg/day) using increments of 100 mg/day given two or three times daily.
Maltese: Il-kura b'Seroquel bdiet b'50 mg/kuljum u f'jum 2 żdiedet għal 100 mg/kuljum; sussegwentement id-doża ġiet titrata għaddoża fil-mira (manija 400-600 mg/kuljum; skizofrenija 400-800 mg/kuljum) permezz ta' inkrementi ta' 100 mg/kuljum li ngħataw darbtejn jew tliet darbiet kuljum.
English: Each tablet contains 50 mg quetiapine (as fumarate)
Maltese: Kull pillola fiha 50 mg ta' quetiapine (bħala fumarate) LISTA
English: Seroquel XR 200 mg prolonged-release tablets quetiapine
Maltese: Seroquel XR 200 mg fih 200 mg ta' quetiapine (bħala quetiapine fumarate)
English: 3 blisters of 10 tablets
Maltese: 3 folji ta' 10 pilloli
English: Seroquel XR 150 mg prolonged-release tablets quetiapine
Maltese: Seroquel XR 150 mg fih 150 mg ta' quetiapine (bħala quetiapine fumarate)
English: In clinical trials, no additional benefit was seen in the 600 mg group compared to the 300 mg group (see section 5.1).
Maltese: Fi provi kliniċi, ma deher l-ebda benefiċċju addizzjonali filgrupp fuq 600 mg meta mqabbel mal-grupp fuq 300 mg (ara sezzjoni 5.1).
English: Each tablet contains 150 mg quetiapine (as fumarate)
Maltese: Kull pillola fiha 150 mg ta' quetiapine (bħala fumarate) LISTA
English: The product information may be subsequently updated by the Member State competent authorities, in liaison with the Reference Member State, as appropriate, in accordance with the procedures laid down in Chapter 4 of Title III of Directive 2001/83/EC.
Maltese: L-informazzjoni dwar il-prodott tista' tiġi aġġornata sussegwentament mill-awtoritajiet kompetenti tal-Istati Membri, b'kollaborazzjon mal-Istat Membru ta' Referenza, kif xieraq, skont il-proċedura stabbilita fil-Kapitolu 4 tat-Titlu III tad-Direttiva 2001/83/KE.
English: Seroquel 300 mg contains 300 mg quetiapine (as quetiapine fumarate) Excipient : 59 mg lactose (anhydrous) per tablet
Maltese: Seroquel 300 mg fih 300 mg ta' quetiapine (bħala quetiapine fumarate)
English: Dizziness 4, 16,
Maltese: Ipotensjoni ortostatika 4,16
English: 10 blisters of 10 tablets
Maltese: 10 folji ta' 10 pilloli
English: There was no difference in magnitude of effect between the patients who received 300 mg Seroquel IR and those who received 600 mg dose.
Maltese: Ma kienx hemm differenza fid-daqs tal-effett bejn ilpazjenti li rċevew 300 mg ta' Seroquel IR u dawk li rċevew doża ta' 600 mg.
English: • Vomiting
Maltese: • Aċċessjonijiet
English: Individual patients may benefit from a 600 mg dose.
Maltese: Pazjenti individwali jistgħu jibbenefikaw minn doża ta' 600 mg.
English: The incidence of shifts to >0.5-<1.0 x 109/L was the same (0.2%) in patients treated with quetiapine as with placebo-treated patients.
Maltese: L-inċidenza ta' tibdil għal >0.5-<1.0 x 109/L kienet l-istess (0.2%) f'pazjenti li ngħataw kura bi quetiapine bħal fil-pazjenti li ngħataw kura bi plaċebo.
English: 1 blister of 6 tablets
Maltese: 6 pillloli folja ta' 6 pilloli
English: INFORMATION IN BRAILLE Seroquel 100 mg (or 150 mg, or 200 mg or 300 mg)
Maltese: ISTRUZZJONIJIET DWAR L-UŻU INFORMAZZJONI BIL-BRAILLE Seroquel 100 mg (jew 150 mg, jew 200 mg jew 300 mg)
English: For the treatment of moderate to severe manic episodes in bipolar disorder For the treatment of manic episodes associated with bipolar disorder, Seroquel should be administered twice a day.
Maltese: Għall-kura ta' episodji manijaċi assoċjati ma' disturbi bipolari, Seroquel għandu jingħata darbtejn kuljum.
English: Quetiapine and the active human plasma metabolite, norquetiapine interact with a broad range of neurotransmitter receptors.
Maltese: Quetiapine u l-metabolit attiv fil-plasma umana, norquetiapine jinteraġixxu ma' firxa wiesgħa ta' riċetturi newrotrasmettituri.
English: The mean quetiapine plasma clearance decreases with approx. 25% in persons with known hepatic impairment (stable alcohol cirrhosis).
Maltese: It-tneħħija medja ta' quetiapine mill-plasma tonqos b'madwar 25% f'persuni b'indeboliment epatiku magħruf (b'ċirrożi alkoħolika stabbli).
English: Pharmacokinetic data were sampled in 9 children aged 10-12 years old and 12 adolescents, who were on steady-state treatment with 400 mg quetiapine twice daily.
Maltese: Dejta farmakokinetika ittieħdet bħala kampjun f'9 itfal bejn l-10-12-il sena u 12-il adolexxenti, li kienu fuq kura fi stat fiss b'400 mg ta' quetiapine darbtejn kuljum.
English: • Fits (seizures).
Maltese: • Erezzjoni fit-tul u bl-uġigħ (Prijapiżmu).
English: Increases in blood pressure were reported in children and adolescents and increased appetite, extrapyramidal symptoms and elevations in serum prolactin were reported with higher frequency in children and adolescents than in adult patients (see sections 4.4 and 4.8).
Maltese: Żidiet fil pressjoni tad-demm kienu rrapportati fi tfal u adolexxenti u żieda fl-aptit, sintomi ekstrapiramidali u żidiet fil-prolactin fis-serum kienu rrapportati bi frekwenza ogħla fit-tfal u l-adolexxenti milli f'pazjenti adulti (ara sezzjonijiet 4.4 u 4.8).
English: At steady-state, the dose-normalised plasma levels of the parent compound, quetiapine, in children and adolescents (10-17 years of age) were in general similar to adults, though Cmax in children was at the higher end of the range observed in adults.
Maltese: Fi stat fiss, il-livelli tad doża normalizzata fil-plasma tal-kompost oriġinali, quetiapine, fi tfal u adolexxenti (10-17-il sena) kienu ġeneralment simili għal dawk fl-adulti, għalkemm fit-tfal is-Cmax kien fil-parti għolja tal medda li kienet osservata fl-adulti.
English: Dizziness 4, 16, somnolence headache, Extrapyramidal symptoms1, 21
Maltese: Sturdament ngħas 2,16, uġigħ ta' ras, Sintomi ekstrapiramidali
English: A 26-week open-label extension to the acute trials (n=380 patients), with Seroquel flexibly dosed at 400800 mg/day, provided additional safety data.
Maltese: Estensjoni b'tikketta miftuħa ta' 26-ġimgħa għall-provi akuti (n=380 pazjent), b'Seroquel mgħoti b'mod flessibbli f'400-800 mg/kuljum, ipprovdiet dejta addizzjonali dwar is-sigurtà.
English: Neutropenia
Maltese: Disartrija
English: At steady-state, the dosenormalized plasma levels of the parent compound, quetiapine, in children and adolescents (10-17 years of age) were in general similar to adults, though Cmax in children was at the higher end of the range observed in adults.
Maltese: Fi stat fiss, il-livelli tad-doża normalizzata fil-plasma tal-kompost oriġinali, quetiapine, fi tfal u adolexxenti (10-17-il sena) kienu ġeneralment simili għal dawk fl-adulti, għalkemm fit-tfal is-Cmax kien fil-parti għolja tal-medda li kienet osservata fl-adulti.
English: Seroquel XR 400 mg prolonged-release tablets quetiapine
Maltese: Seroquel XR 400 mg fih 400 mg ta' quetiapine (bħala quetiapine fumarate)
English: 6 x 25 mg film-coated tablets 2 x 100 mg film-coated tablets
Maltese: 6 x 25 mg pilloli miksjin b'rita 2 x 100 mg pilloli miksjin b'rita
English: Acute withdrawal symptoms such as insomnia, nausea, headache, diarrhoea, vomiting, dizziness, and irritability have been described after abrupt cessation of quetiapine.
Maltese: Sintomi akuti ta' irtirar bħal insomnja, dardir, uġigħ ta' ras, dijarea, rimettar, sturdament, u irritabilità kienu deskritti wara l-waqfien f'daqqa ta' quetiapine.
English: In vitro investigations established that CYP3A4 is the primary enzyme responsible for cytochrome P450 mediated metabolism of quetiapine.
Maltese: Minn studji fuq l-annimali jidher li quetiapine jista' jinduċi enzimi taċ-ċitokromju P450.
English: Based on shifts from normal baseline to potentially clinically important value at anytime post-baseline in all trials.
Maltese: Abbażi ta' tibdil mil-linja bażi normali għal valur potenzjalment klinikament importanti fi kwalunkwe ħin wara l-linja bażi fil-provi kollha.
English: Each tablet contains 200 mg quetiapine (as fumarate)
Maltese: Kull pillola fiha 200 mg ta' quetiapine (bħala fumarate)
English: The daily dose at the start of therapy is 300 mg on Day 1 and 600 mg on Day 2.
Maltese: Fil-bidu tat-terapija d-doża ta' kuljum hija ta' 300 mg f'Jum 1 u ta' 600 mg f'Jum 2.
English: • Swallow your tablets whole with a drink of water.
Maltese: • Ibla' l-pilloli tiegħek sħaħ ma' tazza ilma.
English: • You have problems with your liver.
Maltese: • Għandek problemi bil-fwied tiegħek.
English: Seroquel XR 300 mg prolonged-release tablets quetiapine
Maltese: Seroquel XR 300 mg fih 300 mg ta' quetiapine (bħala quetiapine fumarate)
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 25 mg quetiapine (as fumarate) Each tablet contains 100 mg quetiapine (as fumarate) Each tablet contains 200 mg quetiapine (as fumarate)
Maltese: Kull pillola fiha 25 mg ta' quetiapine (bħala fumarate) Kull pillola fiha 100 mg ta' quetiapine (bħala fumarate)
English: • Serious, sudden allergic reaction with symptoms such as fever and blisters on the skin and peeling of the skin (toxic epidermal necrolysis)
Maltese: • Reazzjoni allerġika serja u f'daqqa b'sintomi bħal deni u nfafet fuq il-ġilda u tqaxxir tal-ġilda (nekroliżi epidermali tossika)
English: The pharmacokinetics of quetiapine were not significantly altered by co-administration of the antidepressants imipramine (a known CYP 2D6 inhibitor) or fluoxetine (a known CYP 3A4 and CYP 2D6 inhibitor).
Maltese: Il-farmakokinetika ta' quetiapine ma kinitx mibdula b'mod sinjifikanti bl-għoti fl-istess ħin tal antidipressanti imipramine (inibitur magħruf ta' CYP 2D6) jew fluoxetine (inibitur magħruf ta'
English: As with other antipsychotics, caution is recommended when treating patients with a history of seizures (see Section 4.8).
Maltese: Bħal b'antipsikotiċi oħra, hija rakkomandata kawtela waqt il-kura ta' pazjenti bi storja ta' aċċessjonijiet (ara Sezzjoni 4.8).
English: Patients should be advised to immediately report the appearance of signs/symptoms consistent with agranulocytosis or infection (e.g., fever, weakness, lethargy, or sore throat) at any time during Seroquel therapy.
Maltese: Il-pazjenti għandhom jingħataw parir biex jirrapportaw minnufih id-dehra ta' sinjali/sintomi konsistenti ma' agranuloċitosi jew infezzjoni (eż., deni, dgħjufija, letarġija, jew uġigħ fil-griżmejn) fi kwalunkwe ħin matul it-terapija b'Seroquel.
English: Bradycardia32
Maltese: Newtropenja1
English: These effects are related to elevated prolactin levels and not directly relevant to humans because of species differences in hormonal control of reproduction
Maltese: Dawn l effetti huma relatati ma' livelli elevati ta' prolactin u mhumiex direttament rilevanti għall-bniedem minħabba differenzi fil-kontroll ormonali tar-riproduzzjoni bejn l-ispeċi.
English: Breastfeeding
Maltese: Newtropenja
English: <[To be completed nationally]>
Maltese: <[ Biex timtela mill-pajjiż partikolari]>
English: Co-administration of quetiapine and phenytoin (another microsomal enzyme inducer) caused a greatly increased clearance of quetiapine by approx. 450%.
Maltese: L-għoti ta' quetiapine flimkien ma' phenytoin (induttur ieħor talenzimi mikrosomali) ikkawża żieda ħafna akbar fit-tneħħija ta' quetiapine b'madwar 450%.
English: In a third short-term placebo-controlled monotherapy trial with Seroquel XR in children and adolescent patients (10-17 years of age) with bipolar depression, efficacy was not demonstrated.
Maltese: F'tielet prova fuq żmien qasir ikkontrollata bi plaċebo b'monoterapija b'Seroquel XR f'pazjenti tfal u adolexxenti (10-17 sena) b'dipressjoni bipolari, l-effikaċja ma ntwerietx.
English: Quetiapine treatment was associated with dose-related decreases in thyroid hormone levels.
Maltese: Kura bi quetiapine kien assoċjata ma' tnaqqis fil-livelli ta' ormoni tat-tirojde relatati mad-doża.
English: 100 mg, 150 mg, 200 mg and 300 mg tablets
Maltese: 10 folji ta' 10 pilloli pilloli ta' 100 mg, 150 mg, 200 mg u 300 mg
English: Based on these in vitro results, it is unlikely that co-administration of quetiapine with other drugs will result in clinically significant drug inhibition of cytochrome P450 mediated metabolism of the other drug.
Maltese: Abbażi ta' dawn ir-riżultati in vitro, mhuwiex probabbli li l-għoti ta' quetiapine flimkien ma' mediċini oħra se jwassal għal inibizzjoni klinikament sinifikanti tal-mediċina tal-metaboliżmu tal-mediċina l-oħra medjat miċ-ċitokromju P450.
English: Based on clinical trial adverse event reports of blood creatine phosphokinase increase not associated with neuroleptic malignant syndrome 15.
Maltese: Abbażi ta' rapporti ta' avvenimenti avversi fil-provi kliniċi ta' żieda fil-creatine phosphokinase fid-demm mhux assoċjata ma' sindromu newrolettiku malinn 15.
English: Seroquel XR contains a substance called quetiapine.
Maltese: Seroquel XR fih sustanza msejħa quetiapine.
English: Prolonged-release tablet
Maltese: Qawwa tal-Pillola
English: Seroquel 3-Day Starterpack (Combined pack) contains 6 tablets Seroquel 25 mg and 2 tablets Seroquel 100 mg
Maltese: Eċċipjent : 59 mg ta' lattosju (anidru) f'kull pillola Seroquel Pakkett tal-Bidu ta' 3 ijiem (Pakkett ikkombinat) fih 6 pilloli Seroquel 25 mg u 2 pilloli Seroquel 100 mg
English: Seroquel XR 50 mg prolonged-release tablets quetiapine
Maltese: Seroquel XR 50 mg pilloli li jerħu l-mediċina bil-mod quetiapine
English: Jaundice Hepatitis
Maltese: 5, Epatite Suffejra
English: An increase in the rate of dysphagia with quetiapine vs. placebo was only observed in the clinical trials in bipolar depression.
Maltese: Żieda fir-rata ta' disfaġja bi quetiapine kontra plaċebo kienet osservata biss fil-provi kliniċi b'dipressjoni bipolari.
English: The effect size of the 600 mg and 800 mg doses was greater than that of the 400 mg dose.
Maltese: Id daqs tal-effett tad-dożi ta' 600 mg u ta' 800 mg kien akbar minn dak tad-doża ta' 400 mg.
English: In patients who develop these symptoms, increasing the dose may be detrimental.
Maltese: F'pazjenti li jiżviluppaw dawn is-sintomi, żieda fid-doża tista' tkun detrimentali.
English: When Seroquel XR administered once daily is compared to the same total daily dose of immediate-release quetiapine fumarate (Seroquel immediate release) administered twice daily, the area under the plasma concentration-time curve (AUC) is equivalent, but the maximum plasma concentration (Cmax) is 13% lower at steady state.
Maltese: Meta Seroquel XR mogħti darba kuljum jiġi mqabbel mal-istess doża totali ta' kuljum ta' quetiapine fumarate b'rilaxx f'daqqa (Seroquel b'rilaxx f'daqqa) mogħti darbtejn kuljum, l-erja taħt il-kurva tal-konċentrazzjoni fil-plasma mal-ħin (AUC) hija ekwivalenti, iżda l konċentrazzjoni massima fil-plasma (Cmax) hija ta' 13% aktar baxxa fi stat fiss.
English: In a study examining the effects of food on the bioavailability of quetiapine, a high-fat meal was found to produce statistically significant increases in the Seroquel XR Cmax and AUC of approximately 50% and 20% respectively., It cannot be excluded that the effect of a high fat meal on the formulation may be larger.
Maltese: Fi studju li eżamina l-effetti tal-ikel fuq il-bijodisponibilità ta' quetiapine, instab li ikla b'kontenut għoli ta' xaħam tikkawża żidiet statistikament sinifikanti fis-Cmax u l-AUC ta' Seroquel XR ta' madwar 50% u 20% rispettivament.
English: Depending on the clinical response and tolerability of the individual patient, the dose may be adjusted within the range 150 to 750 mg/day.
Maltese: Skont ir-rispons kliniku u t-tollerabilità tal-pazjent individwali, id-doża tista' tiġi aġġustata fil-medda ta' bejn 150 sa 750 mg/kuljum.
English: • If you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel (see section 6: Further information)
Maltese: • Jekk inti allerġiku (tbati minn sensittività eċċessiva) għal quetiapine jew għal xi sustanza oħra ta' Seroquel (ara sezzjoni 6: Informazzjoni oħra)
English: It is this combination of receptor antagonism with a higher selectivity for 5HT2 relative to D2- receptors, which is believed to contribute to the clinical antipsychotic properties and low extrapyramidal side effect (EPS) liability of Seroquel compared to typical antispychotics.
Maltese: Din il-kombinazzjoni ta' antagoniżmu għar-riċetturi b'selettività ogħla għal 5HT2 relattiv għal riċetturi-D2, hija maħsuba li tikkontribwixxi għall-karatteristiċi kliniċi antipsikotiċi u l-effett ekstrapiramidali sekondarju (EPS) baxx ta' Seroquel meta mqabbel ma' antipsikotiċi tipiċi.
English: Based on public literature, patients with delerium and agitation and a clear anticholinergic syndrome may be treated with physostigmine, 1-2 mg (under continuous ECG monitoring), This is not recommended as standard treatment, because of potential negative effect of physostigmine on cardiac conductance.
Maltese: Abbażi tal-letteratura pubblika, pazjenti b'delirju u aġitazzjoni u sindromu antikolinerġiku ċar jistgħu jiġu ttrattati b'physostigmine, 1-2 mg (taħt monitoraġġ kontinwu b'ECG), Dan mhuwiex rakkomandat bħala kura standard, minħabba l-effett negattiv potenzjali ta' physostigmine fuq il-konduttanza tal qalb.
English: In individual patients, in the event of tolerance concerns, clinical trials have indicated that dose reduction to a minimum of 200 mg could be considered.
Maltese: F'pazjenti individwali, fil-każ li jkun hemm tħassib dwar it tolleranza, provi kliniċi indikaw li jista' jiġi kkunsidrat tnaqqis fid-doża għal minimu ta' 200 mg.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 100 mg (or 150 mg, or 200 mg or 300 mg) quetiapine (as fumarate)
Maltese: Kull pillola fiha 100 mg (jew 150 mg, jew 200 mg jew 300 mg) ta' quetiapine (bħala fumarate) LISTA
English: In a short-term (9 week) study non-demented elderly patients (aged 66 to 89 years) with major depressive disorder, Seroquel XR dosed flexibly in the range of 50 mg to 300 mg/day demonstrated superior efficacy to placebo in reducing depressive symptoms as measured by improvement in MADRS total score (LS mean change vs placebo -7.54).
Maltese: 50 mg sa 300 mg/kuljum wera effikaċja superjuri għall-plaċebo fit-tnaqqis ta' sintomi depressivi kif imkejjel minn titjib fil-punteġġ totali fuq MADRS (bidla medja fl-LS kontra plaċebo ta' -7.54).