FrancophonIA/ELRC3.0 huggingface dataset:
English: Frequencies have been evaluated on a per patient basis according to the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Učestalost pojavljivanja procijenjena je po bolesniku prema sljedećoj konvenciji: vrlo često (≤1/10), često (≤1/100 i <1/10), manje često (≤1/1000 i <1/100), rijetko (≤1/10 000 i <1/1000), vrlo rijetko (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: It is strongly recommended that every time AFSTYLA is given, you record the date of administration, the batch number and the injected volume in your treatment diary.
Croatian: Izrazito se preporučuje da za svaku primjenu lijeka AFSTYLA bilježite datum primjene, broj serije i ubrizgani volumen u svoj dnevnik liječenja.
English: Study 3002 enrolled a total of 84 previously treated patients <12 years of age (35 <6 years of age and 49 6 to <12 years of age).
Croatian: Ispitivanje 3002 uključilo je ukupno 84 prethodno liječenih bolesnika < 12 godina (35 < 6 godina i 49 u dobi od 6 do < 12 godina).
English: The factor VIII/von Willebrand factor complex consists of two molecules (factor VIII and von Willebrand factor) with different physiological functions.
Croatian: Kompleks faktora VIII i von Willebrandova faktora sastoji se od dviju molekula (faktor VIII i von Willebrandov faktor) s različitim fiziološkim funkcijama.
English: • AFSTYLA must not be mixed with other medicines or solvents except those mentioned in section 6.
Croatian: • AFSTYLA se ne smije miješati s drugim lijekovima ili otapalima osim onih navedenih u dijelu
English: Activated AFSTYLA has an amino acid sequence identical to endogenous FVIIIa.
Croatian: Aktivirani AFSTYLA ima slijed aminokiselina identičan endogenom FVIIIa.
English: Make sure that you only pull away the blister package and not the Mix2Vial set.
Croatian: Pazite da odvojite samo blister pakiranje, a ne i komplet Mix2Vial.
English: Children above 12 years of age can use the same dose as adults.
Croatian: Djeca dobi iznad 12 godina mogu upotrebljavati doze jednake onima za odrasle.
English: In patients with existing cardiovascular risk factors, substitution therapy with factor VIII may increase the cardiovascular risk.
Croatian: U bolesnika s postojećim kardiovaskularnim faktorima rizika, nadomjesna terapija faktorom VIII može povećati kardiovaskularni rizik.
English: The newly formed linkage of the heavy and light chain of factor VIII introduces a new Nglycosylation site.
Croatian: Novonastala veza teških i lakih lanaca faktora VIII uvodi novo mjesto N-glikozilacije.
English: What you need to know before you use AFSTYLA
Croatian: Što morate znati prije nego počnete primjenjivati lijek AFSTYLA
English: Inject every 24 hours, at least 1 day, until healing is achieved.
Croatian: Injekcija svaka 24 sata, barem 1 dan do zacjeljenja.
English: • The powder must be mixed with the solvent (liquid) and withdrawn from the vial under aseptic conditions.
Croatian: • Prašak se mora pomiješati s otapalom (tekućinom) te izvući iz bočice u aseptičkim uvjetima.
English: The dose and duration of the substitution therapy depend on the severity of the factor VIII deficiency, on the location and extent of the bleeding and on the patient's clinical condition.
Croatian: Doziranje i trajanje nadomjesne terapije ovise o težini nedostatka faktora VIII, mjestu i opsegu krvarenja te kliničkom stanju bolesnika.
English: FVIII inhibition uncommon (PTPs)* very common (PUPs)*
Croatian: manje često (PTPs)* vrlo često (PUPs) *
English: Once the product has been taken out of the refrigerator, the product must not be returned to the refrigerator.
Croatian: Jednom kad se lijek izvadi iz hladnjaka, ne smije se više vraćati u hladnjak.
English: Do not expose the vials to direct heat.
Croatian: Nemojte izlagati bočice izravnom izvoru topline.
English: In general, all patients treated with coagulation factor VIII products should be carefully monitored for the development of inhibitors by appropriate clinical observations and laboratory tests.
Croatian: Općenito, sve bolesnike liječene lijekovima koji sadrže koagulacijski faktor VIII potrebno je pažljivo pratiti na razvoj inhibitora pomoću odgovarajućih kliničkih pregleda i laboratorijskih testova zbog razvoja inhibitora.
English: Dose (IU) = body weight (kg) x Desired factor VIII rise (IU/dl or % of normal) x 0.5 (IU/kg per IU/dl)
Croatian: Doza (IU) = tjelesna težina (kg) x željeno povećanje faktora VIII (IU/dl ili % normalne vrijednosti) x 0,5 (IU/kg po IU/dl).
English: Repeat injection every 8 to 24 hours until threat is resolved.
Croatian: Ponavljati injekciju svakih 8 - 24 sata do otklanjanja opasnosti.
English: • The formation of inhibitors (antibodies) is a known complication that can occur during treatment with all Factor VIII medicines.
Croatian: • Stvaranje inhibitora (antitijela) poznata je komplikacija koja se može pojaviti tijekom liječenja bilo kojim lijekom koji sadrži faktor VIII.
English: AFSTYLA can be used for all age groups.
Croatian: AFSTYLA se može primjenjivati u svim dobnim skupinama.
English: In a completed clinical trial a patient who received more than double the prescribed dose of AFSTYLA experienced dizziness, feeling hot, and itching not considered related to AFSTYLA but more plausibly attributed to co-administration of an analgesic.
Croatian: U završenom kliničkom ispitivanju bolesnik koji je primio više od dvostruke propisane doze lijeka AFSTYLA osjetio je omaglicu, osjećaj vrućine, i svrbež za koji se smatra da nije povezan s lijekom AFSTYLA, već je vjerojatnije da se može pripisati istovremenoj primjeni analgetika.
English: If the expected factor VIII activity plasma levels are not attained, or if bleeding is not controlled with an appropriate dose, testing for factor VIII inhibitor presence should be performed.
Croatian: Ako se ne postignu očekivane razine aktivnosti faktora VIII u plazmi ili ako se krvarenje ne može kontrolirati primjerenom odgovarajuće doze, potrebno je napraviti ispitivanje na prisutnost inhibitora faktora VIII.
English: AFSTYLA (INN: lonoctocog alfa) is a recombinant human protein that replaces the missing coagulation factor VIII needed for effective hemostasis.
Croatian: AFSTYLA (INN: lonoktokog alfa) rekombinantni je ljudski protein koji zamjenjuje koagulacijski faktor VIII koji nedostaje, a koji je potreban za učinkovitu hemostazu.
English: - Do not use visibly cloudy solutions or solutions still containing flakes or particles.
Croatian: - Nemojte upotrijebiti vidljivo mutne otopine ili otopine koje još sadrže pahuljice ili čestice.
English: The solvent will automatically flow into the powder vial.
Croatian: Otapalo će automatski protjecati u bočicu s praškom.
English: The amount to be administered and the frequency of administration should always be oriented to the clinical effectiveness in the individual case.
Croatian: Količinu koju treba primijeniti i učestalost primjene uvijek treba uskladiti s kliničkom učinkovitosti u svakom pojedinom slučaju.
English: The calculation of the required dose of factor VIII is based on the empirical finding that 1 International Unit (IU) factor VIII per kg body weight raises the plasma factor VIII activity by 2 IU/dl.
Croatian: Izračun potrebne doze faktora VIII temelji se na empirijskom saznanju da 1 međunarodna jedinica (IU) faktora VIII po kg tjelesne težine povećava aktivnost faktora VIII u plazmi za 2 IU/dl.
English: Hypersensitivity or allergic reactions (which may include angioedema, burning and stinging at the injection site, chills, flushing, generalised urticaria, headache, hives, hypotension, lethargy, nausea, restlessness, tachycardia, tightness of the chest, tingling, vomiting, wheezing) have been observed rarely with the use of factor VIII products and may in some cases progress to severe anaphylaxis (including shock).
Croatian: Reakcije preosjetljivosti ili alergijske reakcije (koje mogu uključivati angioedem, žarenje i peckanje na mjestu injekcije, zimicu, navale crvenila, generaliziranu urtikariju, glavobolju, koprivnjaču, hipotenziju, letargiju, mučninu, nemir, tahikardiju, stezanje u prsištu, trnce, povraćanje, piskanje pri disanju) primijećene su rijetko pri uporabi lijekova s faktorom VIII, a u nekim slučajevima mogu napredovati do teške anafilaksije (uključujući šok).
English: AFSTYLA is a single polypeptide chain with a truncated B-domain that allows for a covalent bridge to link the factor VIII heavy and light chains.
Croatian: AFSTYLA je jednolančani polipeptidni lanac sa skraćenom B-domenom, što omogućava kovalentno povezivanje teških i lakih lanaca faktora VIII.
English: Individual patients may vary in their responses to factor VIII, demonstrating different half-lives and recoveries.
Croatian: Pojedini bolesnici mogu imati različite odgovore na faktor VIII, pri čemu se postižu različite vrijednosti poluvijekova i povrata.
English: For injection of AFSTYLA the provided administration sets are recommended to be used because treatment failure can occur as a consequence of factor VIII adsorption to the internal surface of some injection equipment.
Croatian: Za injiciranje lijeka AFSTYLA preporučuje se upotreba priloženih kompleta za primjenu jer se može dogoditi neuspjeh u liječenju kao posljedica adsorpcije faktora VIII na unutarnje površine neke opreme za injiciranje.
English: Repeat injection every 12 to 24 hours for 3-4 days or more until pain and acute disability are resolved.
Croatian: Ponavljati injekciju svakih 12 do 24 sata tijekom 3 - 4 dana ili dulje do prestanka boli i akutne onesposobljenosti.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with AFSTYLA in the treatment of hereditary factor VIII deficiency in previously untreated paediatric patients (PUPs) (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka AFSTYLA za liječenje nasljednog nedostatka faktora VIII za prethodno neliječene pedijatrijske ispitanike (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: If you use more AFSTYLA than you should If you have injected more AFSTYLA than you should, please inform your doctor.
Croatian: Ako ste ubrizgali više lijeka AFSTYLA nego što ste trebali, obavijestite svog liječnika.
English: All patients had been diagnosed with severe haemophilia A with <1% factor VIII.
Croatian: Svi bolesnici imali su dijagnozu teške hemofilije A s <1 % faktora VIII.
English: • Once the product has been taken out of the refrigerator, the product must not be returned to the refrigerator.
Croatian: • Jednom kad se lijek izvadi iz hladnjaka, ne smije se više vraćati u hladnjak.
English: 1 filter transfer device 20/20
Croatian: 1 naprava za prijenos s filtrom 20/20
English: It is a construct where most of the B-domain occurring in wild-type, full-length factor VIII and 4 amino acids of the adjacent acidic a3 domain were removed (amino acids 765 to 1652 of full-length factor VIII).
Croatian: Radi se o konstruktu kojem je uklonjena većina B-domene koja je prisutna u divljem tipu faktora VIII pune duljine i 4 aminokiseline susjedne kisele a3 domene (aminokiseline 765 do 1652 faktora VIII pune duljine).
English: The median dose to treat a bleeding episode was 34.7 IU/kg.
Croatian: Medijan doze za liječenje epizode krvarenja bio je 34,7 IU/kg.
English: IR and Cmax were baseline corrected while the remaining parameters were not baseline corrected with N = 81.
Croatian: Vrijednosti IR i Cmax korigirane su za početne vrijednosti, dok ostali parametri nisu korigirani za početne vrijednosti sa N = 81.
English: Haemophilia A is an x-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII and results in profuse bleeding into joints, muscles or internal organs, either spontaneously or as result of accidental or surgical trauma.
Croatian: Hemofilija A je X-vezani nasljedni poremećaj koagulacije krvi uslijed smanjenih razina faktora VIII, a uzrokuje obilno krvarenje u zglobove, mišiće ili unutarnje organe, koje može nastati spontano ili kao posljedica slučajne ili kirurške traume.
English: Factor VIII level required (%) (IU/dl)
Croatian: Potrebna razina faktora VIII (%)(IU/dl)
English: Treatment of bleeding: Of the 848 bleeding events observed during Study 1001, 93.5% were controlled with 2 or fewer injections.
Croatian: Liječenje krvarenja: Od 848 događaja krvarenja zabilježenih tijekom ispitivanja 1001, 93,5% je bilo kontrolirano pomoću 2 ili manje injekcija.
English: Based on the rare occurrence of haemophilia A in women, experience regarding the use of factor VIII during pregnancy and breast-feeding is not available.
Croatian: Budući da se hemofilija A rijetko javlja u žena, iskustva s primjenom faktora VIII tijekom trudnoće i dojenja nisu dostupna.
English: The AFSTYLA solution must not be diluted.
Croatian: Otopina lijeka AFSTYLA ne smije se razrijediti.
English: 25 °C) for a single period not exceeding 3 months, within the expiration date printed on the cartons and the vials.
Croatian: 25 °C) tijekom jednokratnog razdoblja ne dužeg od 3 mjeseca, unutar roka valjanosti otisnutoga na kutijama i bočicama.
English: The following table can be used to guide dosing in bleeding episodes and surgery: Degree of haemorrhage / Type of surgical procedure
Croatian: Sljedeća se tablica može upotrijebiti kao vodič za doziranje kod epizoda krvarenja i kirurških zahvata: Stupanj krvarenja / vrsta kirurškog zahvata
English: This medicine contains up to 7 mg (0.3 mmol) sodium per ml after reconstitution.
Croatian: Ovaj lijek sadrži do 7 mg (0,3 mmol) natrija po ml nakon rekonstitucije.
English: In the case of the following haemorrhagic events, the factor VIII activity should not fall below the given plasma activity level (in % of normal or IU/dl) within the corresponding period.
Croatian: U slučaju sljedećih događaja krvarenja, aktivnost faktora VIII ne smije pasti ispod navedene razine aktivnosti u plazmi (izražene u % normalne vrijednosti ili u IU/dl) u odgovarajućem razdoblju.
English: Driving and using machines AFSTYLA does not affect your ability to drive and use machines.
Croatian: Upravljanje vozilima i strojevima AFSTYLA ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: As the furin cleavage site present in wild type factor VIII between the Bdomain and the a3 domain was removed, AFSTYLA is expressed as a single-chain factor VIII molecule.
Croatian: Budući da je uklonjeno mjesto cijepanja za furin u divljem tipu faktora VIII između B-domene i a3 domene, AFSTYLA se eksprimira kao molekula jednolančanog faktora VIII.
English: Treatment of bleeding: Of the 347 bleeding events observed during Study 3002, 95.7%were controlled with 2 or fewer injections.
Croatian: Liječenje krvarenja: Od 347 događaja krvarenja zabilježenih tijekom ispitivanja 3002, 95,7 % je bilo kontrolirano pomoću 2 ili manje injekcija.
English: AFSTYLA is a human clotting (coagulation) factor VIII product that is produced by recombinant DNA technology.
Croatian: AFSTYLA je lijek s ljudskim faktorom zgrušavanja (koagulacije) VIII koji se proizvodi tehnologijom rekombinantne DNK.
English: AFSTYLA contains up to 7 mg (0.3 mmol) sodium per ml after reconstitution.
Croatian: AFSTYLA sadrži do 7 mg (0,3 mmol) natrija po ml nakon rekonstitucije.
English: Carefully remove the protective caps from the vials, and clean the exposed rubber stoppers with an alcohol swab.
Croatian: Pažljivo uklonite zaštitne poklopce s bočica i očistite izložene gumene čepove blazinicama natopljenima alkoholom.
English: Feeling hot uncommon *Frequency is based on studies with all FVIII products which included patients with severe haemophilia A. PTPs = previously-treated patients, PUPs = previously-untreated patients.
Croatian: *Učestalost se temelji na ispitivanjima sa svim lijekovima s FVIII koja su uključivala bolesnike s teškom hemofilijom A. PTPs=prethodno liječeni bolesnici (engl. previously-treated patients), PUPs=prethodno neliječeni bolesnici (engl. previously-untreated patients).
English: 2.5 ml [for reconstitution of strengths 250/500/1000 IU] 5 ml [for reconstitution of strengths 1500/2000/2500/3000 IU]
Croatian: 2,5 ml [za rekonstituciju lijeka jačine 250/500/1000 IU] 5 ml [za rekonstituciju lijeka jačine 1500/2000/2500/3000 IU]
English: • Any unused product or waste material should be disposed of in accordance with local requirements and as instructed by your doctor.
Croatian: • Neiskorišteni lijek ili otpadni materijal potrebno je zbrinuti sukladno nacionalnim propisima te prema uputama liječnika.
English: AFSTYLA has no influence on the ability to drive and use machines.
Croatian: AFSTYLA ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: The study participants accumulated a total of 5,239 EDs with rVIIISingleChain.
Croatian: Ispitanici su skupili ukupno 5239 dana izloženosti s jednolančanim faktorom rVIII.
English: The frequencies in the table below were observed in completed clinical studies in previously treated patients with severe haemophilia A.
Croatian: Učestalosti navedene u donjoj tablici su zabilježene u završenim kliničkim ispitivanjima kod prethodno liječenih bolesnika sa teškom hemofilijom A.
English: By replacement therapy the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of the bleeding tendencies.
Croatian: Nadomjesnom terapijom povećavaju se razine faktora VIII u plazmi, čime se omogućuje privremena korekcija nedostatka faktora te korekcija sklonosti krvarenju.
English: Use the venipuncture kit supplied with the product, insert the needle into a vein.
Croatian: Upotrijebite set za venepunkciju koji je priložen s ovim lijekom te stavite iglu u venu.
English: The study enrolled 175 previously treated patients (12 to 65 years of age) with severe haemophilia A (1 subject >60 years of age was enrolled) who accumulated a total of 14,306 EDs with rVIII-SingleChain.
Croatian: Ispitivanje je uključilo 175 prethodno liječenih bolesnika (u dobi od 12 do 65 godina) s teškom hemofilijom A (bio je uključen 1 ispitanik >60 godina starosti) koji su skupili ukupno 14 306 dana izloženosti s jednolančanim faktorom rVIII.
English: If symptoms of allergic reactions occur, stop using the medicine immediately and contact your doctor.
Croatian: Ako se pojave simptomi alergijskih reakcija, odmah prestanite primjenjivati lijek i obratite se liječniku.
English: Inject the reconstituted solution slowly (as comfortable for you, up to a maximum of 10 ml/min) into the vein following the instructions given to you by your doctor.
Croatian: Polako ubrizgajte rekonstituiranu otopinu (brzinom koja Vam je ugodna, do najviše 10 ml/min intravenski slijedeći upute koje Vam da liječnik.
English: The recommended starting regimen in children (0 to <12 years of age) is 30 to 50 IU per kg of AFSTYLA administered 2 to 3 times weekly.
Croatian: Preporučeni početni režim u djece (od 0 do <12 godina) jest od 30 do 50 IU/kg lijeka AFSTYLA primijenjeno 2 do 3 puta tjedno.
English: AFSTYLA is a single-chain recombinant human factor VIII produced in Chinese hamster ovary (CHO) cells.
Croatian: AFSTYLA je jednolančani rekombinantni ljudski faktor VIII koji se proizvodi na staničnoj liniji jajnika kineskoga hrčka (CHO).
English: When infused into a haemophiliac patient, factor VIII binds to von Willebrand factor in the patient's circulation.
Croatian: Kada se primijeni infuzijom u bolesnika s hemofilijom, faktor VIII veže se na von Willebrandov faktor u cirkulaciji bolesnika.
English: After filtering or withdrawal (see below) the solution should be checked by eye, before it is used.
Croatian: Nakon filtriranja ili izvlačenja (vidjeti u nastavku), a prije same primjene, otopinu treba vizualno provjeriti.
English: Factor VIII activity in plasma is expressed either as a percentage (relative to normal human plasma) or preferably in International Units (relative to an International Standard for factor VIII in plasma).
Croatian: Aktivnost faktora VIII u plazmi izražava se ili postotkom (u odnosu na normalnu ljudsku plazmu) ili radije u međunarodnim jedinicama (u odnosu na međunarodni standard za faktor VIII u plazmi).
English: The pharmacokinetics (PK) of AFSTYLA were evaluated in 10 previously treated adolescents (12 to <18 years of age) and 39 previously treated children (0 to <12 years of age) following an intravenous injection of a single dose of 50 IU/kg.
Croatian: Farmakokinetika lijeka AFSTYLA procijenjena je u 10 prethodno liječenih adolescenata (u dobi od 12 do <18 godina) i 39 prethodno liječene djece (u dobi od 0 do <12 godina) nakon intravenske injekcije jedne doze od 50 IU/kg.
English: • The solution should be clear or slightly opalescent, yellow to colourless, i.e., it might be sparkling when held up to the light but must not contain any obvious particles.
Croatian: • Otopina treba biti bistra ili blago opalescentna, žuta do bezbojna, tj. može se sjajiti kad se drži prema svjetlu, ali ne smije sadržavati nikakve vidljive čestice.
English: The one-stage clotting assay result underestimates the factor VIII activity level compared to the chromogenic assay result by approximately 45%.
Croatian: Jednostupanjski test koagulacije podcjenjuje razinu aktivnosti faktora VIII u usporedbi s rezultatom kromogenog testa za oko 45 %.
English: If not used immediately, in-use storage times and conditions prior to use are in the responsibility of the user.
Croatian: Ako se ne primijeni odmah, trajanje i uvjeti čuvanja do primjene lijeka odgovornost su korisnika.
English: These include hives, generalised skin rash, tightness of the chest, wheezing, fall in blood pressure and anaphylaxis (a serious allergic reaction that causes severe difficulty in breathing, and dizziness).
Croatian: Oni uključuju koprivnjaču, generalizirani kožni osip, stezanje u prsištu, piskanje pri disanju, pad krvnog tlaka i anafilaksiju (ozbiljnu alergijsku reakciju koja uzrokuje jako otežano disanje i omaglicu).
English: If you stop using AFSTYLA
Croatian: Ako prestanete primjenjivati lijek AFSTYLA
English: Ensure powder and solvent vial flip caps are removed and the stoppers are treated with an antiseptic solution and allowed to dry prior to opening the Mix2Vial package.
Croatian: Pobrinite se da uklonite poklopce s bočica praška i otapala i čepove obradite antiseptičkom otopinom i pustite da se osuše prije otvaranja pakiranja naprave Mix2Vial .
English: The reconstituted preparation should be injected slowly at a rate comfortable for the patient at a maximum injection rate of 10 ml/min.
Croatian: Rekonstituirani pripravak treba se ubrizgavati polako brzinom koja je ugodna za bolesnika, a maksimalnom brzinom ubrizgavanja od 10 ml/min.
English: Development of neutralizing antibodies (inhibitors) may occur in patients with haemophilia A treated with factor VIII, including with AFSTYLA.
Croatian: Do razvoja neutralizirajućih antitijela (inhibitora) može doći u bolesnika s hemofilijom A koji su liječeni faktorom VIII, uključujući Afstylu.
English: If you forget to use AFSTYLA
Croatian: Ako ste zaboravili primijeniti lijek AFSTYLA
English: One International Unit (IU) of factor VIII activity is equivalent to that quantity of factor VIII in one ml of normal human plasma.
Croatian: Jedna međunarodna jedinica (IU) aktivnosti faktora VIII jednaka je količini faktora VIII u jednome ml normalne ljudske plazme.
English: In the case of major surgical interventions in particular, precise monitoring of the substitution therapy by means of coagulation analysis (plasma factor VIII activity) is indispensable.
Croatian: Osobito u slučaju većih kirurških zahvata neizostavno je precizno praćenje nadomjesne terapije pomoću analize koagulacija (određivanja aktivnosti faktora VIII u plazmi).
English: The reconstituted solution should be administered by a separate injection/infusion line by slow intravenous injection, at a rate comfortable to the patient, up to a maximum of 10 ml/min.
Croatian: Rekonstituirana otopina treba se primijeniti zasebnom injekcijskom/infuzijskom linijom sporom intravenskom injekcijom, brzinom koja je ugodna za bolesnika, do najviše 10 ml/min.