FrancophonIA/ELRC3.0 huggingface dataset:
English: Medicinal products that prevent or reduce platelet aggregation should not be started for at least 3 days after the procedure.
Croatian: Lijekovi koji sprječavaju ili smanjuju agregaciju trombocita ne smiju se uzimati najmanje 3 dana nakon postupka.
English: Concomitant use of systemic VEGF inhibitors is not recommended with TOOKAD.
Croatian: Ne preporučuje se istodobna uporaba sistemskih VEGF inhibitora s lijekom TOOKAD.
English: No in vitro or in vivo studies have been conducted with radiolabelled padeliporfin.
Croatian: Ni in vitro ni in vivo ispitivanja nisu provedena s radioaktivno označenim padeliporfinom.
English: Radical therapy post VTP procedure
Croatian: Radikalna terapija nakon VTP postupka
English: Penile swelling (balanoposthitis).
Croatian: 13 Oticanje penisa (balanopostitis).
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the marketing authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom planu upravljanja rizikom (RMP), koji se nalazi u modulu 1.8.2. odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMPa.
English: One serious adverse event of prostatic abscess which was considered severe was reported in the study performed in Latin America in a patient who had a unilateral VTP procedure.
Croatian: U ispitivanju provedenom u Latinskoj Americi prijavljen je jedan ozbiljan štetan događaj apscesa prostate u bolesnika koji je podvrgnut unilateralnom VTP postupku.
English: If you have had an active inflammatory bowel disease or any condition that may increase the risk of causing abnormal connection between the rectum and the urethra (recto-urethral fistula), the treatment should be given only after careful evaluation.
Croatian: Ako ste bolovali od aktivne upalne bolesti crijeva ili bilo kojeg stanja koje može povećati rizik od stvaranja abnormalnih veza između rektuma (završnog dijela crijeva) i mokraćne cijevi (rektouretralna fistula), liječenje se vrši isključivo nakon pažljive procjene.
English: Treatment should not be undertaken in patients where an LDI ≥ 1 cannot be achieved (see section 5.1).
Croatian: Kod bolesnika kod kojih nije moguće postići LDI ≥ 1, liječenje se ne bi trebalo izvoditi (vidjeti dio 5.1).
English: Your doctor may prescribe antibiotics to prevent infection and alpha-blockers (medicines given to prevent difficulties in urinating).
Croatian: Liječnik može propisati antibiotike za sprječavanje infekcije i alfa blokatore (lijekove za sprječavanje poteškoća pri mokrenju).
English: Only use light bulbs with a maximum power of 60 watts (for an incandescent light bulb) or 6 watts (for LED lights), or 12 watts (for fluorescent low-energy lights).
Croatian: Smiju se upotrebljavati samo žarulje sa žarnom niti snage od najviše 60 vata (za žarulje sa žarnom niti) ili 6 vati (za LED žarulje), ili 12 vati (za fluorescentnu niskoenergetsku rasvjetu).
English: White blood cell count increased
Croatian: Povećan broj bijelih krvnih zrnaca
English: If it is not possible to stop a photosensitising medicine (such as amiodarone), increased sensitivity may occur, you may need to protect yourself from direct light exposure for a longer period.
Croatian: Ako nije moguće prestati uzimati fotosenzibilizirajuće lijekove (poput amiodarona), može doći do pojačane osjetljivosti i tada može biti potrebno zaštititi se od izlaganja izravnom svjetlu dulje vremena.
English: Antiplatelet agents (medicines that decrease platelet aggregation (stickiness) in the blood and reduce clotting)
Croatian: Antitrombocitni lijekovi (lijekovi koji smanjuju nakupljanje (lijepljenje) trombocita u krvi i smanjuju zgrušavanje)
English: The magnitude of interaction has not been investigated clinically but a transient increase in the plasma concentration of co-administered substrates of OATP1B1 and OATP1B3 cannot be ruled out.
Croatian: Značaj interakcija nije klinički ispitan, ali se ne može isključiti privremeno povećanje koncentracije u plazmi istodobno primijenjenih supstrata OATP1B1 i OATP1B3.
English: Haematoma Hypertension
Croatian: Hematom Hipertenzija
English: In patients with localised prostate cancer who received TOOKAD-VTP, necrosis was observed by Magnetic Resonance Imaging (MRI) at day 7.
Croatian: U bolesnika s lokaliziranim rakom prostate koji su primili TOOKAD-VTP terapiju, nekroza se uočila oslikavanjem magnetskom rezonancijom 7. dan.
English: However, the short duration of action of TOOKAD means that the risk of enhanced phototoxicity is expected to be low provided these patients strictly follow the precautions against light exposure.
Croatian: Ipak, kratko djelovanje lijeka TOOKAD znači da se očekuje niži rizik pojačane fototoksičnosti pod uvjetom da bolesnici strogo slijede mjere opreza vezane uz izlaganje svjetlosti.
English: The safety and efficacy of subsequent radical therapy (surgery or radiotherapy) is uncertain.
Croatian: Sigurnost i djelotvornost radikalne terapije (operacije ili zračenja) koja slijedi nakon VTP-a nije jasna.
English: You may go outdoors during daylight hours but only in shaded areas or when it is overcast.
Croatian: Dopušten je izlazak na danju svjetlost, ali samo u zasjenjena područja ili kad je oblačno.
English: This is enhanced by RNS-induced endothelial cell apoptosis and initiation of self-propagated tumour cells necrosis through peroxidation of their membrane.
Croatian: To je pojačano apoptozom endotelnih stanica induciranom reaktivnim dušikovim spojevima i inicijacijom nekroze tumorskih stanica koja se sama širi putem peroksidacije njihove membrane.
English: Very few patients aged over 75 years were enrolled into studies where pharmacokinetic measurements were taken so it is not known if there is a difference in these older patients compared to patients less than 75 years of age (see sections 4.2 and 5.1).
Croatian: Starija populacija Veoma je malen broj bolesnika starijih od 75 godina bio uključen u ispitivanja s farmakokinetičkim mjerenjima, tako da nije poznato postoji li razlika između starijih bolesnika i onih mlađih od 75 godina
English: PSA should be tested every 3 months for first 2 years post VTP and every 6-months thereafter in order to assess PSA dynamics (PSA Doubling Time (DT), PSA velocity).
Croatian: PSA treba se određivati svaka 3 mjeseca prve 2 godine nakon VTP terapije i svakih 6 mjeseci nakon toga kako bi se procijenila dinamika vrijednosti PSA (vrijeme udvostručenja vrijednosti PSA, brzina porasta vrijednosti PSA).
English: When the analysis was restricted to patients that underwent unilateral VTP, 33 (16.8 %) patients experienced erectile dysfunction for more than 6 months, including 17 (8.6 %) patients in whom the erectile dysfunction had not resolved at the end of the study.
Croatian: Kad je analiza bila ograničena na bolesnike koji su podvrgnuti unilateralnom VTP-u, 33 (16,8 %) bolesnika imalo je erektilnu disfunkciju dulje od 6 mjeseci, uključujući 17 (8,6 %) bolesnika u kojih erektilna disfunkcija nije prestala do završetka ispitivanja.
English: This may also cause bruising, haematuria and/or local pain.
Croatian: To također može uzrokovati pojavu modrica, hematurije i/ili lokalnu bol.
English: See also under “Other medicines and TOOKAD” for photosensitizing medicines.
Croatian: Pogledajte dio „Drugi lijekovi i TOOKAD” u vezi s fotosenzibilizirajućim lijekovima.
English: Due to the photosensitising properties of TOOKAD, the content of the vial should then be transferred into an opaque syringe that should be held in an upright position for 3 minutes to ensure any foam disappears.
Croatian: Zbog fotosenzibilizirajućih svojstava lijeka TOOKAD sadržaj bočice treba premjestiti u neprozirnu štrcaljku koju treba držati u uspravnom položaju 3 minute kako bi nestala pjena.
English: Reconstitution of the TOOKAD powder for solution for injection The solution must be prepared in a dimmed-light environment due to the photosensitizing properties of the medicine.
Croatian: Rekonstitucija TOOKAD praška za otopinu za injekciju Otopina se mora pripremati u okruženju prigušenog svjetla zbog fotosenzibilizirajućih svojstava lijeka.
English: AS involved serial absolute PSA measurements and ultrasound-guided prostatic biospy at 12 and 24 months.
Croatian: Aktivno praćenje (AS) je uključivalo serijska apsolutna mjerenja vrijednosti PSA i ultrazvučno vođenu biopsiju prostate nakon 12 i 24 mjeseca.
English: The median time to onset of urinary retention was 3 days (1-417).
Croatian: Medijan vremena do pojave urinarne retencije iznosio je 3 dana (1 - 417).
English: • Explain what the VTP procedure involves, including the need to follow the rules to protect the Patient against light after the procedure for 48 hours, due to the photosensitising effect of TOOKAD and provide a copy of the TOOKAD Package Leaflet to the Patient ahead of the VTP procedure
Croatian: • Objašnjenje o tome što VTP terapija obuhvaća, uključujući potrebu za poštivanjem pravila radi zaštite bolesnika od svjetlosti nakon postupka idućih 48 sati zbog fotosenzibilizirajućeg učinka lijeka TOOKAD i osiguravanje primjerka upute o lijeku TOOKAD bolesniku prije provedbe VTP postupka.
English: One patient had Grade 3 prostatitis considered as serious that started 4 days after the VTP procedure, and lasted for 31 days before resolving without sequelae.
Croatian: Jedan bolesnik imao je prostatitis 3. stupnja koji se smatrao ozbiljnim i koji je započeo 4 dana nakon VTP postupka, i trajao je 31 dan prije nego što se povukao bez posljedica.
English: Unspecific adverse events probably linked to the general anaesthesia were also observed: transient global amnesia, bradycardia, sinus arrhythmia, atrial fibrillation, hypotension, bronchospasm, pharyngeal inflammation, respiratory tract congestion, nausea, vomiting, constipation, pyrexia, procedural hypotension.
Croatian: Nespecifični štetni događaji vjerojatno povezani s općom anestezijom također su uočeni: prolazna opća amnezija, bradikardija, sinusna aritmija, fibrilacija atrija, hipotenzija, bronhospazam, faringealna upala, kongestija respiratornog sustava, mučnina, povraćanje, konstipacija, vrućica, proceduralna hipotenzija.
English: For instructions on reconstitution of TOOKAD before administration, see section 6.6.
Croatian: Za upute o rekonstituciji lijeka TOOKAD prije primjene vidjeti dio 6.6.
English: The median time to onset of urinary incontinence was 4 days (1-142).
Croatian: Medijan vremena do pojave urinarne inkontinencije iznosio je 4 dana (1 - 142).
English: Excessive extraprostatic necrosis occurred as a result of incorrect calibration of the laser or placement of the light fibres (see section 4.8).
Croatian: Prekomjerna izvanprostatna nekroza koja se pojavila kao posljedica nepravilne kalibracije lasera ili nepravilnog postavljanja svjetlosnih vlakana (vidjeti dio 4.8).
English: Minimal seminiferous epithelial degeneration was also recorded in one high-dose male with vacuolation.
Croatian: Zabilježen je jedan slučaj minimalne epitelne degeneracije sjemenovoda u mužjaka pri visokoj dozi s vakuolacijom.
English: Anticoagulants and antiplatelet agents
Croatian: Antikoagulansi i antitrombocitni lijekovi
English: Its volume is measured after prostate delineation using the treatment guidance software.
Croatian: Volumen se mjeri nakon delineacije prostate uporabom terapijskog vodiča kao programske podrške.
English: First 12 hours after VTP procedure
Croatian: Prvih 12 sati nakon VTP terapije
English: Once it has been given, TOOKAD has to be activated by laser light shone along a fibre that targets the light onto the cancer.
Croatian: Nakon ubrizgavanja, TOOKAD se aktivira laserskim svjetlom duž vlakna kojima se svjetlost cilja na rak.
English: TOOKAD is restricted to hospital use only.
Croatian: Uporaba lijeka TOOKAD ograničena je isključivo na bolničku primjenu.
English: However, as the procedure includes general anaesthesia, patients should not perform complex tasks like driving or using machines until 24 hours after a general anaesthetic is employed.
Croatian: Ipak, budući da postupak uključuje opću anesteziju, bolesnik ne smije izvoditi složene radnje poput upravljanja vozilom ili rada sa strojevima do 24 sata nakon primitka opće anestezije.
English: If you feel skin or eye discomfort while in hospital, you must tell your doctor or nurse so the level of lighting can be reduced and extra care can be taken to protect you from artificial and natural light.
Croatian: Ako osjetite nelagodu na koži ili u očima za vrijeme boravka u bolnici, potrebno je obavijestiti liječnika ili medicinsku sestre tako da smanje razinu osvjetljenja i zaštite Vas od umjetnog i prirodnog svjetla.
English: In other cases, urethral stenosis may have been a late consequence of TOOKAD-VTP induced necrosis.
Croatian: U ostalim slučajevima uretralna stenoza može biti kasna posljedica nekroze izazvane
English: This medicinal product contains potassium and in general the dose (3.66 mg/kg) will be less than 1 mmol (39 mg) i.e. essentially ‘potassium free'.
Croatian: Ovaj lijek sadrži kalij i općenito, doza (3,66 mg/kg) sadrži manje od 1 mmol (39 mg), tj. zanemarive količine kalija.
English: However, as the procedure includes general anaesthesia, you should not perform complex tasks like driving or using machines until 24 hours after a general anaesthetic is used.
Croatian: Ipak, budući da postupak uključuje opću anesteziju, ne smiju se izvoditi složene radnje poput upravljanja vozilom ili rada sa strojevima do 24 sata nakon primitka opće anestezije.
English: Submission of final study results:
Croatian: Podnošenje konačnih rezultata
English: After reconstitution with a 5 % glucose solution in its vial, the chemical and physical stability of TOOKAD has been demonstrated for 8 hours at 15°C-25°C and at 5°C ± 3°C.
Croatian: Nakon rekonstitucije s 5 %-tnom otopinom glukoze u svojoj bočici, kemijska i fizikalna stabilnost lijeka TOOKAD dokazana je tijekom 8 sati na temperaturi od 15 °C - 25 °C i na 5 °C ± 3 °C.
English: This medicine is stored under the responsibility of the specialist.
Croatian: Za čuvanje ovog lijeka su odgovorni specijalisti.
English: Patients in the AS arm were not offered subsequent VTP.
Croatian: Bolesnicima u skupini AS nije ponuđena sljedeća VTP terapija.
English: If the patient must go outdoors during daylight hours, he should wear protective clothes and high protection goggles to shield his skin and eyes.
Croatian: Ako bolesnik mora izići na danju svjetlost, trebao bi nositi zaštitnu odjeću i zaštitne naočale kako bi zaštitio kožu i oči.
English: This medicine contains potassium.
Croatian: Ovaj lijek sadrži kalij.
English: Padeliporfin has not been tested for reproductive toxicity and fertility.
Croatian: Nije ispitan učinak padeliporfina vezano uz reproduktivnu toksičnost i plodnost.
English: 7 Place du Théâtre L-2613 Luxembourg Luxembourg
Croatian: L-2613 Luxembourg
English: If it is not possible to stop a photosensitising medicinal product (such as amiodarone), the patient should be advised that increased sensitivity to sunlight may occur and they may need to protect themselves from direct light exposure for a longer period (see section 4.2).
Croatian: Ako nije moguće prestati uzimati fotosenzibilizirajući lijek (kao što je amiodaron), bolesnika treba upozoriti na moguću povećanu osjetljivost na sunčevu svjetlost i na potrebu zaštite od izravnog izlaganja svjetlosti na dulje vrijeme (vidjeti dio 4.2).
English: It is not expected that a delay in clotting will reduce the effectiveness of the TOOKAD-VTP treatment ; however, it is recommended that drugs that affect clotting are stopped prior to and for the immediate period following the VTP procedure (see section 4.5).
Croatian: Ne očekuje se da će sporije zgrušavanje umanjiti učinkovitost liječenja TOOKADVTP terapijom; ipak, preporučuje se prestanak uzimanja lijekova koji utječu na zgrušavanje krvi prije i odmah nakon VTP postupka (vidjeti dio 4.5).
English: Urinary incontinence (urge incontinence, incontinence, stress urinary incontinence).
Croatian: 8 Urinarna inkontinencija (urgentna inkontinencija, inkontinencija, stres inkontinencija).
English: The patient may go outdoors during daylight hours but only in shaded areas or when it is overcast.
Croatian: Bolesnik smije izaći na danju svjetlost, ali samo u zasjenjena područja ili kad je oblačno.
English: Current exacerbation of rectal inflammatory bowel disease (see section 4.4).
Croatian: Trenutačno pogoršanje rektalne upale bolesti crijeva (vidjeti dio 4.4).
English: A urinary fistula has occurred in one case due to incorrect fibre placement.
Croatian: Zabilježen je jedan slučaj urinarne fistule do koje je došlo zbog nepravilnog postavljanja vlakna.
English: The risk of sphincter damage can be minimised by careful planning of the fibre placement using the treatment guidance software.
Croatian: Rizik od oštećenja sfinktera može se minimizirati pažljivim planiranjem postavljanja vlakana korištenjem terapijskog vodiča u obliku programske podrške.
English: One case of external urethral fistula occurred due to fibre misplacement (see section 4.4).
Croatian: Jedan slučaj vanjske uretralne fistule dogodio se zbog pogrešnog postavljanja vlakana (vidjeti dio 4.4).
English: AS arm N = 78
Croatian: AS skupina N = 78
English: In the Phase III European study, 60 (30.5 %) of patients in the TOOKAD-VTP arm experienced erectile dysfunction and 16 (8.1 %) experienced ejaculation failure.
Croatian: U europskom ispitivanju faze III, 60 (30,5 %) bolesnika u skupini TOOKAD-VTP imalo je erektilnu disfunkciju, a 16 (8,1 %) bolesnika imalo je nemogućnost ejakulacije.
English: Progression to Gleason ≥ 4 49 (23.8) Number of subjects progressed in the treated lobe* at Month 24, n (%)
Croatian: Progresija na Gleason ≥ 4 49 (23,8) 91 (44,0) 19 (23,8) Broj ispitanika s progresijom u liječenom režnju* u 24. mjesecu, n
English: If you have received prior VEGF therapy, you should take particular care to protect your eyes from light for 48 hours post TOOKAD injection.
Croatian: Ako ste ranije primili anti-VEGF terapiju, trebate posebno zaštititi oči od svjetlosti tijekom 48 sati od injiciranja lijeka TOOKAD.
English: - You are having an exacerbation of rectal inflammatory bowel disease.
Croatian: - ako imate pogoršanje rektalne upalne bolesti crijeva;
English: Effects of covariates on pharmacokinetic properties The effects of age, weight and race were investigated in healthy volunteers and patients.
Croatian: U zdravih dobrovoljaca i bolesnika istražili su se učinci dobi, težine i rase.
English: How TOOKAD is used
Croatian: Kako se TOOKAD primjenjuje
English: 4.4 Special warnings and precautions for use
Croatian: 4.4 Posebna upozorenja i mjere opreza pri uporabi Lokalizacija tumora
English: In the Phase III European study, 20 (10.2 %) patients in the TOOKAD-VTP arm experienced genito-urinary infection.
Croatian: europskom ispitivanju faze III, 20 (10,2 %) bolesnika u skupini TOOKAD-VTP imalo je infekciju genitalno-urinarnog sustava.
English: Urethral stenosis Urinary incontinence
Croatian: Uretralna stenoza Urinarna inkontinencija8
English: If the patient reports discomfort to the skin or eyes during hospitalisation, reduce the level of lighting and take extra care to shield the patient from artificial and natural light.
Croatian: Ako bolesnik prijavi nelagodu u području kože ili očiju tijekom hospitalizacije, potrebno je sniziti razinu osvjetljenja i zaštititi bolesnika od umjetnog i prirodnog svjetla.
English: The chemical and physical stability of TOOKAD after reconstitution with 5 % glucose solution, in its vial, has been demonstrated for 8 hours at 15°C-25°C and at 5°C ± 3°C.
Croatian: Kemijska i fizikalna stabilnost lijeka TOOKAD nakon rekonstitucije s 5 %-tnom otopinom glukoze, u svojoj bočici, dokazana je tijekom 8 sati na temperaturi od 15 °C - 25 °C i na 5 °C ± 3 °C.
English: Standard handling of syringes should follow.
Croatian: Potrebno je slijediti uobičajeno rukovanje štrcaljkama.
English: In healthy human male subjects, the Cmax was shown to be linear from 1.25 mg/kg to 15 mg/kg of padeliporfin di-potassium, covering the therapeutic range.
Croatian: U zdravih muških ispitanika, pokazalo se da je Cmax linearan u rasponu doza od 1,25 mg/kg do 15 mg/kg padeliporfindikalija, što pokriva terapijski raspon.
English: You should wear dark clothes and take care to protect your hands and face from the sun.
Croatian: Treba nositi tamniju odjeću i paziti na izlaganje ruku i lica suncu.
English: In the Phase III European study, 30 (15.2 %) patients experienced urinary retention.
Croatian: U europskom ispitivanju faze III, 30 (15,2 %) bolesnika imalo je urinarnu retenciju.
English: Table 2 gives baseline characteristics by arm.
Croatian: Tablica 2. prikazuje početne značajke po skupinama.
English: This should be taken into consideration in patients with reduced kidney function or patients on a controlled potassium diet where a rise in serum potassium would be considered detrimental (see section 4.2).
Croatian: To treba uzeti u obzir u bolesnika sa smanjenom bubrežnom funkcijom ili bolesnika na dijeti s ograničenim unosom kalija u kojih se porast kalija u serumu smatra štetnim (vidjeti dio 4.2).
English: The reconstituted solution is dark.
Croatian: Rekonstituirana je otopina tamna.
English: Hollow needles are used to insert the fibres into the right place in the prostate.
Croatian: Šupljim iglama umeću se vlakna na pravo mjesto u prostati.
English: Abnormal clotting is not expected to affect how well the treatment works ; however, it is recommended that drugs that affect clotting are stopped prior to and for the immediate period following the VTP procedure.
Croatian: Ne očekuje se da će abnormalno zgrušavanje utjecati na djelotvornost liječenja; ipak, preporučuje se prestanak uzimanja lijekova koji utječu na zgrušavanje krvi prije i odmah nakon VTP terapije.
English: Transfer the contents of the vial into an opaque syringe.
Croatian: Prebacite sadržaj bočice u neprozirnu štrcaljku.
English: Urethral stenosis
Croatian: Uretralna stenoza
English: The vial should rest in an upright position for 3 minutes without further shaking or moving.
Croatian: Bočicu treba ostaviti u uspravnom položaju 3 minute bez daljnjeg mućkanja ili pomicanja.
English: There is limited biopsy data beyond 2 years after TOOKAD treatment, so long-term efficacy has not been determined.
Croatian: Daljnje praćenje nakon primjene postupka TOOKAD-VTP Biopsijski podaci nakon dvije godine od liječenja lijekom TOOKAD su ograničeni, tako da nije utvrđena dugoročna djelotvornost.
English: There is limited clinical information on overdose involving TOOKAD.
Croatian: Kliničke su informacije o predoziranju lijekom TOOKAD ograničene.
English: Prostatic abscess
Croatian: Apsces prostate
English: VTP procedure.
Croatian: TOOKAD-VTP postupkom.
English: The vial should then be swirled gently for 2 minutes.
Croatian: Bočica se nakon toga nježno vrti 2 minute.
English: In vitro studies indicate that TOOKAD does not inhibit P-gp, OAT1, OAT3, OCT2, OCT1, BCRP and BSEP but it could inhibit both OATP1B1 and OATP1B3 transporters (see section 4.5).
Croatian: In vitro ispitivanja pokazuju da TOOKAD ne inhibira P-gp, OAT1, OAT3, OCT2, OCT1, BCRP i BSEP, ali može inhibirati transportere OATP1B1 i OATP1B3 (vidjeti dio 4.5).
English: TOOKAD-VTP arm N = 80
Croatian: TOOKAD-VTP skupina N = 80
English: Patients who have received prior VEGF therapy should take particular care to protect the eyes from light for 48 hours post TOOKAD injection.
Croatian: Bolesnici koji su prethodno primili VEGF terapiju trebaju posebno zaštititi oči od svjetlosti tijekom 48 sati nakon injiciranja lijeka TOOKAD.
English: Following TOOKAD VTP, patients should undergo digital rectal examination (DRE) and have their serum PSA monitored, including an assessment of PSA dynamics (PSA doubling time and PSA velocity).
Croatian: Nakon TOOKAD-VTP terapije bolesnici trebaju biti podvrgnuti digitalnom rektalnom pregledu (engl. digital rectal examination, DRE) uz praćenje PSA u serumu, uključujući procjenu dinamike vrijednosti PSA (vrijeme udvostručenja vrijednosti PSA i brzina porasta vrijednosti PSA).