FrancophonIA/ELRC3.0 huggingface dataset:
English: 6.5 Nature and contents of container White High Density Polyethylene (HDPE) bottles containing 480 capsules.
Slovenian: Bele plastenke iz polietilena visoke gostote (HDPE), ki vsebujejo 480 kapsul.
English: Agenerase must not be administered concurrently with medicinal products with narrow therapeutic windows that are substrates of cytochrome P450 3A4 (CYP3A4).
Slovenian: Zdravilo Agenerase se ne sme uporabljati sočasno z zdravili ozke terapevtske širine, ki so substrat za citokrom P450 3A4 (CYP3A4).
English: The use of the following medicines, together with Agenerase, should only take place on the basis of medical advice: anaesthetics (e.g. lidocaine), antibiotics (e.g. rifabutin, clarithromycin, dapsone and erythromycin), antifungals (e.g. ketoconazole, itraconazole), antimalarials (e.g. halofantrine), anticonvulsant medicines (e.g. carbamazepine, phenytoin and phenobarbital), calcium channel blockers (e.g. amlodipine, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine and verapamil), cholesterol lowering medicines (e.g. atorvastatin, lovastatin and simvastatin), erectile dysfunction medicines (e.g. sildenafil and vardenafil), non-nucleoside reverse transcriptase inhibitors (e.g. delavirdine, efavirenz and nevirapine), opioids (e.g. methadone), hormones like oestrogens and progestogens (e.g. hormonal contraceptives such as the ‘pill'), some glucocorticoids (e.g. fluticasone propionate and budesonide), tricyclic antidepressants (i.e. desipramine and nortriptyline), sedative agents (e.g. midazolam administered by injection), paroxetine, and others (e.g. clozapine and loratadine).
Slovenian: Naslednja zdravila se smejo uporabljati sočasno z zdravilom Agenerase le, če tako odredi zdravnik: anestetiki (npr. lidokain), antibiotiki (npr. rifabutin, klaritromicin, dapson in eritromicin), antimikotiki (npr. ketokonazol, itrakonazol), antimalariki (npr. halofantrin), antiepileptiki (npr. karbamazepin, fenitoin in fenobarbital), zaviralci kalcijevih kanalčkov (npr. amlodipin, diltiazem, felodipin, isradipin, nikardipin, nifedipin, nimodipin, nisoldipin in verapamil), zdravila za zniževanje holesterola (npr. atorvastatin, lovastatin in simvastatin), zdravila proti motnjam erekcije (npr. sildenafil in vardenafil), nenukleozidni zaviralci reverzne transkriptaze (npr. delavirdin, efavirenz in nevirapin), opioidi (npr. metadon), hormoni kot so estrogeni in progestogeni (npr. hormonski kontraceptivi kot so kontracepcijske tabletke), nekateri glukokortikoidi (npr. flutikazonpropionat in budezonid), triciklični antidepresivi (npr. dezipramin in nortriptilin), pomirjevala (npr. midazolam v obliki injekcije), paroksetin in druga (klozapin in loratadin).
English: The long-term consequences of these events are currently unknown.
Slovenian: Dolgotrajne posledice takšnega dogajanja trenutno niso poznane, vedenje o mehanizmu pa je nepopolno.
English: These combinations should be used with caution and therapeutic concentration monitoring is recommended (see section 4.4).
Slovenian: Priporočamo nadziranje terapevtskih koncentracij (glejte poglavje 4.4).
English: The other ingredients are propylene glycol, macrogol 400 (polyethylene glycol 400), d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), acesulfame potassium, saccharin sodium, sodium chloride, artificial grape bubblegum flavour, natural peppermint flavour, menthol, citric acid anhydrous, sodium citrate dihydrate, purified water.
Slovenian: Pomožne snovi so: propilenglikol, makrogol 400, D-α-tokoferilpolietilenglikol 1000 sukcinat (TPGS), kalijev acesulfamat, saharin natrijeva sol, natrijev klorid, umetna aroma žvečilnega gumija z okusom grozdja, naravna aroma poprove mete, mentol, brezvodna citronska kislina, natrijev citrat dihidrat, prečiščena voda.
English: NAME OF THE MEDICINAL PRODUCT Agenerase 15 mg/ml oral solution Amprenavir
Slovenian: IME ZDRAVILA Agenerase 15 mg/ml peroralna raztopina
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product
Slovenian: Če katerega koli sladkorja ne prenašate, to povejte svojemu zdravniku, še preden prvič vzamete to zdravilo.
English: Paroxetine: plasma concentrations of paroxetine may be significantly decreased when co-administered with amprenavir and ritonavir.
Slovenian: Paroksetin: Med sočasno uporabo z amprenavirjem in ritonavirjem se lahko koncentracija paroksetina v plazmi bistveno zmanjša.
English: Caution is advised when Agenerase is used concomitantly with PDE5 inhibitors (e.g. sildenafil and vardenafil) (see section 4.5).
Slovenian: Pri sočasni uporabi zdravila Agenerase in zaviralcev PDE5 (npr. sildenafil in vardenafil) svetujemo previdnost (glejte poglavje 4.5).
English: In the studies of PI-experienced patients, PRO30017 (amprenavir 600 mg / ritonavir 100 mg twice daily in sub-study A and B with 80 and 37 patients respectively), the following mutations emerged in patients with virological failure: L10F/I/V, V11I, I13V, K20R, V32I, L33F, E34Q, M36I, M46I/L, I47V, G48V, I50V, I54L/M/T/V, Q58E, D60E, I62V, A71V, V77I, V82A/I, I84V, I85V, L90M and I93L/M.
Slovenian: V študijah bolnikov, ki so že bili zdravljeni z zaviralci proteaz, PRO30017 (amprenavir 600 mg / ritonavir 100 mg dvakrat na dan in podštudijah A in B, v katere je bilo vključenih 80 oziroma 37 bolnikov), so se pri bolnikih z virusnim neodzivom pojavile naslednje mutacije: L10F/I/V, V11I, I13V, K20R, V32I, L33F, E34Q, M36I, M46I/L, I47V, G48V, I50V, I54L/M/T/V, Q58E, D60E, I62V, A71V, V77I, V82A/I, I84V, I85V, L90M in I93L/M.
English: - Redistribution, accumulation or loss of body fat may occur in patients receiving combination antiretroviral therapy.
Slovenian: - Pri bolnikih, ki se zdravijo s kombiniranim protiretrovirusnim zdravljenjem, se lahko pojavi prerazdelitev, kopičenje ali izguba telesnega maščevja.
English: Indinavir: the AUC, Cmin and Cmax of indinavir were decreased by 38 %, 27 %, and 22 %, respectively, when given with amprenavir.
Slovenian: Indinavir: Ob sočasnem dajanju z amprenavirjem so se AUC, Cmin in Cmax indinavirja zmanjšale, in sicer AUC za 38 %, Cmin za 27 % in Cmax za 22 %.
English: Caution is advised when Agenerase is used concomitantly with delavirdine (see section 4.5).
Slovenian: Pri sočasni uporabi zdravila Agenerase in delavirdina svetujemo previdnost (glejte poglavje 4.5).
English: Additionally, it is recommended that HIV infected women do not breast-feed their infants in order to avoid transmission of HIV.
Slovenian: Še več, priporočljivo je, da matere, okužene z virusom HIV, otrok sploh ne dojijo, saj se tako izognejo eni od možnosti za širjenje virusa HIV.
English: The benefit of Agenerase boosted with ritonavir has not been demonstrated in PI naïve patients (see section 5.1)
Slovenian: Pri bolnikih, ki še niso bili zdravljeni s PI-jem, korist okrepitve učinka zdravila Agenerase z ritonavirjem ni bila dokazana (glejte poglavje 5.1).
English: Bottle contents : 240 ml oral solution containing 15 mg/ml amprenavir.
Slovenian: Plastenka vsebuje: 240 ml peroralne raztopine, ki vsebuje 15 mg/ml amprenavirja.
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Slovenian: Med kombiniranim protiretrovirusnim zdravljenjem so se pri bolnikih z obstoječimi motnjami v delovanju jeter, vključno s kroničnim aktivnim hepatitisom, pogosteje pojavljale nepravilnosti v jetrnem delovanju in jih je bilo potrebno nadzirati po splošno uveljavljenih načelih.
English: Only one case (a buffalo hump) was reported in 113 (< 1 %) antiretroviral naive subjects treated with amprenavir in combination with lamivudine/zidovudine for a median duration of 36 weeks.
Slovenian: Med 113 bolniki, ki predhodno še niso bili zdravljeni s protiretrovirusnimi zdravili in so 36 tednov (srednji čas zdravljenja) prejemali amprenavir v kombinaciji z lamivudinom/zidovudinom, so poročali le o enem primeru (bivolja grba; < 1 %).
English: In some cases, your doctor may adapt the dose of Agenerase when other drugs are administered concomitantly with Agenerase.
Slovenian: V nekaterih primerih sočasne uporabe zdravila Agenerase in drugih zdravil lahko vaš zdravnik prilagodi odmerek zdravila Agenerase.
English: These soft capsules are oblong, opaque, off white to cream in colour and marked with the code GX CC2.
Slovenian: Mehke kapsule so podolgovate, neprozorne, sivobele do krem barve in označene z oznako GX CC2.
English: Common side effects (these can affect 1 to 10 in 100 patients treated)
Slovenian: Pogosti neželeni učinki (ki se lahko pojavijo pri 1 do 10 od 100 zdravljenih bolnikov)
English: No recommendations can currently be made regarding adjustment of amprenavir dose when amprenavir is co-administered with methadone.
Slovenian: Priporočil glede prilagajanja odmerka amprenavirja, če se le-ta uporablja sočasno z metadonom, ne moremo podati.
English: - Adults and adolescents (of 12 years of age and older), (greater than 50 kg body weight): the usual dose of Agenerase capsules is 600 mg twice daily with ritonavir 100 mg twice daily, in combination with other antiretroviral medicinal products.
Slovenian: - Odrasli in mladostniki (stari 12 let in starejši; s telesno težo, večjo od 50 kg): Običajen odmerek kapsul Agenerase je 600 mg dvakrat dnevno skupaj z ritonavirjem v odmerku 100 mg dvakrat dnevno in v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: A reduction of rifabutin dosage of at least 50 % is recommended when administered with Agenerase (see section 4.5).
Slovenian: Če se rifabutin daje sočasno z zdravilom Agenerase priporočamo, da se odmerek rifabutina zmanjša vsaj za 50 % (glejte poglavje 4.5).
English: The AUC and Cmax of amprenavir were increased by 31 % and decreased by 16 %, respectively.
Slovenian: AUC amprenavirja se je zvišala za 31 %, Cmax amprenavirja pa znižala za 16 %.
English: Agenerase, in combination with other antiretroviral agents, is indicated for the treatment of protease inhibitor (PI) experienced HIV-1 infected adults and children above the age of 4 years.
Slovenian: Zdravilo Agenerase je, v kombinaciji z drugimi protiretrovirusnimi zdravili, indicirano za zdravljenje odraslih in otrok, starejših od 4 let, ki so okuženi z virusom humane imunske pomanjkljivosti tipa 1 (HIV-1) in so predhodno že bili zdravljeni z zaviralcem proteaz (PI-jem).
English: HOW TO STORE AGENERASE
Slovenian: SHRANJEVANJE ZDRAVILA AGENERASE
English: Because Agenerase oral solution contains vitamin E, you should not take additional vitamin E supplements.
Slovenian: Ker peroralna raztopina Agenerase vsebujejo vitamin E, le-tega ne jemljite še dodatno.
English: For some medicinal products that can cause serious or life-threatening undesirable effects, such as carbamazepine, phenobarbital, phenytoin, tricyclic antidepressants and warfarin (monitor International Normalised Ratio), concentration monitoring is available; this should minimise the risk of potential safety problems with concomitant use.
Slovenian: Nekatera zdravila, kot so: karbamazepin, fenobarbital, fenitoin, triciklični antidepresivi in varfarin (nadzirati internacionalno normalizirano razmerje) lahko povzročijo resne ali življenjsko usodne neželene učinke.
English: The full prescribing information for ritonavir must therefore be consulted prior to initiation of therapy with Agenerase and ritonavir.
Slovenian: Pred pričetkom zdravljenja z zdravilom Agenerase in ritonavirjem je tako potrebno natančno preveriti podatke o predpisovanju ritonavirja.
English: Agenerase oral solution, in combination with other antiretroviral agents, is indicated for the treatment of protease inhibitor (PI) experienced HIV-1 infected adults and children above the age of 4 years.
Slovenian: Peroralna raztopina Agenerase je, v kombinaciji z drugimi protiretrovirusnimi zdravili, indicirana za zdravljenje odraslih in otrok, starejših od 4 let, ki so okuženi z virusom humane imunske pomanjkljivosti tipa 1 (HIV-1) in so predhodno že bili zdravljeni z zaviralcem proteaz (PI-jem).
English: Agenerase may be less effective due to decreased amprenavir plasma concentrations in patients taking these medicinal products concomitantly (see section 4.5).
Slovenian: Pri bolnikih, ki jemljejo omenjena zdravila sočasno z zdravilom Agenerase se učinkovitost slednjega lahko zmanjša zaradi zmanjšanih koncentracij amprenavirja v plazmi (glejte poglavje 4.5).
English: Therefore medicinal products that are inducers, inhibitors or substrates of CYP3A4 must be used with caution when administered concurrently with Agenerase (see sections 4.3, 4.4 and 4.5).
Slovenian: Amprenavir je substrat za CYP3A4 in ga zavira, zato je potrebna previdnost pri sočasni uporabi zdravil, ki so induktorji, zaviralci ali substrati CYP3A4, in zdravila Agenerase (glejte poglavja 4.3, 4.4, in 4.5).
English: A dosedependent increase in placental weight was found in the rabbit and rat which may indicate effects on placental function.
Slovenian: Tako pri kunčicah kot pri podganah so opazili povečanje teže posteljice v odvisnosti od odmerka, kar bi lahko pomenilo, da amprenavir vpliva na funkcijo placente.
English: Agenerase capsules should be swallowed whole with water or another drink.
Slovenian: Jemanje zdravila Agenerase skupaj s hrano in pijačo Kapsule Agenerase morate pogoltniti cele skupaj z vodo ali drugo pijačo.
English: These soft capsules are oblong, opaque, off white to cream in colour and marked with the code GX CC1.
Slovenian: Mehke kapsule so podolgovate, neprozorne, sivobele do krem barve in označene z oznako GX CC1.
English: Combination antiretroviral therapy has been associated with the redistribution of body fat (lipodystrophy) in HIV patients.
Slovenian: Pri bolnikih, okuženih z virusom HIV, je bilo kombinirano protiretrovirusno zdravljenje povezano s prerazdelitvijo telesnega maščevja (lipodistrofija).
English: In the same study, the AUC, Cmax, and Cmin of amprenavir were increased 72%, 12%, and 483%, respectively, when compared to values after standard doses of amprenavir (1200 mg twice daily).
Slovenian: V isti študiji so se, v primerjavi z doseženimi vrednostmi po običajnih odmerkih amprenavirja (1200 mg dvakrat dnevno), AUC, Cmax in Cmin amprenavirja zvečale, in sicer AUC za 72 %, Cmax za 12 % in Cmin za 483 %.
English: Each Agenerase capsule contains 150 mg of amprenavir.
Slovenian: Vsaka kapsula Agenerase vsebuje 150 mg amprenavirja.
English: Agenerase is used in protease inhibitor experienced HIV-1 infected adults and children above the age of 4 years.
Slovenian: Zdravilo Agenerase se uporablja pri odraslih in otrocih, starejših od 4 let, ki so okuženi z virusom HIV-1 in so že bili zdravljeni z zaviralcem proteaz.
English: Each Agenerase capsule contains 50 mg of amprenavir.
Slovenian: Vsaka kapsula Agenerase vsebuje 50 mg amprenavirja.
English: Uncommon side effects (these can affect less than 1 in 100 patients treated)
Slovenian: Občasni neželeni učinki (ki se lahko pojavijo pri manj kot 10 od 100 zdravljenih bolnikov)
English: In clinical trials, doses of amprenavir 600 mg twice daily and ritonavir 100 mg twice daily have been used; confirming the safety and efficacy of this regimen.
Slovenian: Da bi potrdili varnost in učinkovitost takšnega načina odmerjanja, so v kliničnih študijah uporabljali amprenavir v odmerku 600 mg dvakrat dnevno in ritonavir v odmerku 100 mg dvakrat dnevno.
English: Co-administration may result in competitive inhibition of the metabolism of these medicinal products and create the potential for serious and/or life-threatening adverse events such as cardiac arrhythmia (e.g. amiodarone, bepridil, quinidine, terfenadine, astemizole, cisapride, pimozide), respiratory depression and /or prolonged sedation (e.g. oral triazolam and oral midazolam (for caution on parenterally administred midazolam, see section 4.5)) or peripheral vasospasm or ischaemia and ischaemia of other tissues, including cerebral or myocardial ischaemia (e.g. ergot derivatives).
Slovenian: Sočasna uporaba ima lahko za posledico kompetitivno inhibicijo presnavljanja teh zdravil in izzove možnost hujših in/ali življenjsko usodnih neželenih učinkov, kot so: aritmija (npr. amiodaron, bepridil, kinidin, terfenadin, astemizol, cisaprid, pimozid), depresija dihanja in/ali podaljšana sedacija (npr. peroralna uporaba triazolama ali midazolama (glede previdnostnih ukrepov ob parenteralni uporabi midazolama glejte poglavje 4.5)) ali periferni vazospazem ali ishemija in ishemija drugih tkiv, vključno s cerebralno ali miokardno ishemijo (npr. derivati ergot alkaloidov).
English: Coadministration with Agenerase may substantially increase PDE5 inhibitor plasma concentrations and associated adverse events, including hypotension, visual changes and priapism (see section 4.4).
Slovenian: Zaradi sočasne uporabe zdravila Agenerase in zaviralcev PDE5 se lahko znatno povišajo plazemske koncentracije slednjih, kar lahko privede do neželenih dogodkov, vključno s hipotenzijo, motnjami vida in priapizmom (glejte poglavje 4.4)..
English: PI-experienced adults, boosted Agenerase capsules
Slovenian: Odrasli, ki so se že zdravili s PI-ji; okrepljeno zdravilo Agenerase v obliki kapsul
English: Various regimens have been assessed in the amprenavir/fosamprenavir development programs with and without co-administration of ritonavir.
Slovenian: V razvojnem programu uporabe amprenavirja/fosamprenavirja s sočasno uporabo ritonavirja ali brez so bili ovrednoteni različni režimi zdravljenja.
English: In the studies of PI-experienced patients, APV30003 and its extension, APV30005 (fosamprenavir 700 mg / ritonavir 100 mg twice daily: n=107), the following mutations emerged in patients experiencing virological failure through 96 weeks: L10F/I, L24I, V32I, L33F, M36I, M46I/L, I47V, I50V, I54L/M/S, A71I/T/V, G73S, V82A, I84V, and L90M.
Slovenian: V študijah bolnikov, ki so že bili zdravljeni z zaviralci proteaz, APV30003 in njenem podaljšku, APV30005 (fosamprenavir 700 mg / ritonavir 100 mg dvakrat na dan: n=107), so se pri bolnikih z virusnim neodzivom med 96 tedni zdravljenja pojavile naslednje mutacije: L10F/I, L24I, V32I, L33F, M36I, M46I/L, I47V, I50V, I54L/M/S, A71I/T/V, G73S, V82A, I84V in L90M.
English: Ketoconazole / Itraconazole: the AUC and Cmax of ketoconazole were increased by 44 % and 19 % respectively when given with amprenavir.
Slovenian: Ketokonazol/itrakonazol: Pri sočasni uporabi ketokonazola in amprenavirja sta se AUC in Cmax ketokonazola zvišali, in sicer AUC za 44 %, Cmax pa za 19 %.
English: Agenerase oral solution is also contraindicated in patients treated with disulfiram or other medicinal products that reduce alcohol metabolism (e.g. metronidazole) and preparations that contain alcohol (e.g. ritonavir oral solution) or additional propylene glycol (see section 4.4and 5.1).
Slovenian: Ravno tako je peroralna raztopina Agenerase kontraindicirana pri bolnikih, ki se zdravijo z disulfiramom ali drugimi zdravili, ki zmanjšujejo presnovo alkohola (npr. metronidazol), pripravki z alkoholom (npr. peroralna raztopina ritonavirja) ali pripravki z dodatnim propilenglikolom (glejte poglavji 4.4 in 5.1).
English: Adults and adolescents of 12 years of age and older (greater than 50 kg body weight): the recommended dose of Agenerase capsules is 600 mg twice daily with ritonavir, 100 mg twice daily, in combination with other antiretroviral agents.
Slovenian: Odrasli in mladostniki, stari 12 let ali več (s telesno maso, večjo od 50 kg): Priporočen odmerek kapsul Agenerase je 600 mg dvakrat dnevno skupaj z ritonavirjem v odmerku 100 mg dvakrat dnevno in v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: No dose adjustment is necessary for either medicinal product when nelfinavir is administered in combination with amprenavir (see also efavirenz below).
Slovenian: Ob sočasni uporabi nelfinavirja in amprenavirja njunih odmerkov ni potrebno prilagajati (glejte tudi Efavirenz spodaj).
English: • Pain, discomfort or excess acid in the stomach, loose stools,
Slovenian: • Bolečina in neugodje v želodcu.
English: HIV-1 isolates with decreased susceptibility to amprenavir have been selected during in vitro serial passage experiments.
Slovenian: Med serijskimi pasažami in vitro so izolirali izolate virusa HIV-1 z zmanjšano občutljivostjo za amprenavir.
English: The AUC, Cmin and Cmax of amprenavir were increased by 33 %, 25 %, and 18 %, respectively.
Slovenian: AUC, Cmin in Cmax amprenavirja so se zvečale: AUC za 33 %, Cmin za 25 % in Cmax za 18 %.
English: Agenerase capsules should be used with caution in patients with hepatic impairment.
Slovenian: Pri bolnikih z oslabljenim delovanjem jeter je potrebna previdnost pri uporabi kapsul Agenerase.
English: Saquinavir: the AUC, Cmin and Cmax of saquinavir were decreased by 19 % and 48 % and increased by 21 %, respectively, when given with amprenavir.
Slovenian: Sakvinavir: Ob sočasnem dajanju z amprenavirjem sta se AUC in Cmin sakvinavirja zmanjšali, in sicer AUC za 19 %, Cmin pa za 48 %; Cmax sakvinavirja se je zvišala za 21 %.
English: Agenerase can be taken with or without food.
Slovenian: Zdravilo Agenerase smete jemati s hrano ali brez nje.
English: Patients with chronic hepatitis B or C and treated with antiretroviral agents are at increased risk for severe and potentially fatal liver adverse events and may require blood tests for control of liver function.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki se zdravijo s protiretrovirusnimi zdravili, obstaja povečano tveganje za pojav hudih, lahko tudi usodnih, z jetri povezanih neželenih učinkov.
English: When ART naïve patients were treated with the currently approved doses of fosamprenavir/ritonavir, as for other ritonavir boosted PI regimens, the mutations described were rarely observed.
Slovenian: Pri bolnikih, ki se predhodno še niso zdravili s protiretrovirusnimi zdravili, so se pri zdravljenju s trenutno priporočenimi odmerki fosamprenavirja/ritonavirja opisane mutacije pojavile redko, podobno kot pri drugih režimih zdravljenja z zaviralci proteaz z okrepitvijo z ritonavirjem.
English: The AUC, Cmin and Cmax of amprenavir were increased by 18 %, 39 %, and 15 % respectively.
Slovenian: AUC, Cmin in Cmax amprenavirja so se zvečale, in sicer AUC za 18 %, Cmin za 39 % in Cmax za 15 %.
English: What Agenerase looks like and the contents of the pack Agenerase 150 mg soft capsules are supplied in plastic bottles containing 240 soft capsules.
Slovenian: Zdravilo Agenerase v obliki 150 mg mehkih kapsul je na voljo v plastenkah, ki vsebujejo 240 mehkih kapsul.
English: The AUC, Cmin and Cmax of amprenavir were decreased by 32 %, 14 %, and 37 %, respectively.
Slovenian: AUC, Cmin in Cmax amprenavirja so se zmanjšale: AUC za 32 %, Cmin za 14 % in Cmax za 37 %.
English: This is due to induction of drug metabolising enzymes by St John's wort.
Slovenian: Slednje je posledica šentjanževkine indukcije presnovnih encimov zdravila.
English: The AUC, Cmin and Cmax of amprenavir were increased by 29 %, 27 %, and 47 %, respectively.
Slovenian: AUC, Cmin in Cmax amprenavirja so se zvečale: AUC za 29 %, Cmin za 27 % in Cmax za 47 %.
English: Agenerase oral solution is supplied in plastic bottles containing 240 ml of oral solution.
Slovenian: Peroralna raztopina Agenerase je na voljo v plastenkah, ki vsebujejo 240 ml peroralne raztopine.
English: Psychiatric disorders Common:
Slovenian: Bolezni živčevja Zelo pogosti:
English: Nelfinavir: the AUC, Cmin and Cmax of nelfinavir were increased by 15 %, 14 %, and 12 % respectively when given with amprenavir.
Slovenian: Nelfinavir: Ob sočasnem dajanju z amprenavirjem so se AUC, Cmin in Cmax nelfinavirja zvečale, in sicer AUC za 15 %, Cmin za 14 % in Cmax za 12 %.