FrancophonIA/ELRC3.0 huggingface dataset:
English: In rabbits, maternal toxicity (including mortality and abortions) was noted at 225 mg/kg/day (approximately 2-fold the AUC at the RHD); in the offspring, an increased incidence of malformations and variations in the vertebrae and ribs were observed.
Danish: Hos kaniner blev maternel toksicitet (herunder mortalitet og aborter) bemærket ved 225 mg/kg/dag (ca. 2 gange AUC ved RHD); hos afkommet blev der observeret en øget incidens af misdannelser af og forandringer i ryghvirvler og ribben.
English: Antidiabetic medicinal products repaglinide
Danish: Antidiabetika repaglinid
English: CMV DNA was monitored on a weekly basis until posttransplant Week 14, and subsequently bi-weekly until Week 24.
Danish: CMV-DNA blev monitoreret en gang om ugen indtil uge 14 efter transplantation og herefter hver anden uge indtil uge 24.
English: Testicular toxicity was not observed in mice and monkeys at the highest doses tested at exposures up to 4-fold and 2-fold, respectively, the exposures in humans at the RHD.
Danish: Testikeltoksicitet blev ikke observeret hos mus og aber ved de højeste afprøvede doser ved eksponeringer på op til henholdsvis 4 gange og 2 gange eksponeringerne hos mennesker ved RHD.
English: Some patients have reported fatigue (feeling very tired) or vertigo (feeling like you are spinning) during treatment with PREVYMIS.
Danish: Nogle patienter har rapporteret træthedsfølelse eller vertigo (snurrende fornemmelse) under behandlingen med Prevymis.
English: In a Phase 2b trial evaluating letermovir doses of 60, 120, or 240 mg/day or placebo for up to 84 days in 131 HSCT recipients, DNA sequence analysis of a select region of UL56 (amino acids 231 to 369) was performed on samples obtained from 12 letermovir-treated subjects who experienced prophylaxis failure and for whom samples were available for analysis.
Danish: I et fase 2b-studie, hvor doser af letermovir på 60, 120 eller 240 mg/dag eller placebo i op til 84 dage blev vurderet hos 131 HSCT-recipienter, blev der foretaget DNA-sekvensanalyse af et udvalgt område af UL56 (aminosyre 231 til 369) på prøver indhentet fra 12 letermovir-behandlede forsøgspersoner, der oplevede profylaksesvigt, og hvis prøver var tilgængelige for analyse.
English: The changes in letermovir exposure due to moderate or severe renal impairment are not considered to be clinically relevant.
Danish: Ændringerne i eksponeringen for letermovir som følge af moderat eller svært nedsat nyrefunktion anses ikke for at være klinisk relevante.
English: Adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant To evaluate letermovir prophylaxis as a preventive strategy for CMV infection or disease, the efficacy of letermovir was assessed in a multicenter, double-blind, placebo-controlled Phase 3 trial (P001) in adult CMV-seropositive recipients [R+] of an allogeneic HSCT.
Danish: Voksne CMV-seropositive recipienter [R+] af allogen hæmatopoietisk stamcelletransplantation Med henblik på at vurdere profylakse med letermovir som en forebyggelsesstrategi mod CMVinfektion eller -sygdom blev letermovirs virkning vurderet i et dobbeltblindet, placebokontrolleret fase 3-multicenterstudie (P001) hos voksne CMV-seropositive recipienter [R+] af allogen HSCT.
English: No dose adjustment of PREVYMIS is recommended for patients with mild, moderate, or severe renal impairment.
Danish: Det anbefales ikke at justere dosis af PREVYMIS hos patienter med let, moderat eller svært nedsat nyrefunktion.
English: Antipsychotics thioridazine
Danish: Antipsykotika thioridazin
English: * Population post-hoc predictions from the population PK analysis using Phase 3 data
Danish: *Post hoc-populationsprædiktioner fra den farmakokinetiske populationsanalyse, hvor fase 3-data blev benyttet.
English: There was no developmental toxicity observed up to the highest exposure tested (2-fold the AUC at the RHD).
Danish: Der blev ikke observeret udviklingstoksicitet ved op til den højeste afprøvede eksponering (2 gange AUC ved RHD).
English: ↑ midazolam IV:
Danish: ↑ midazolam Intravenøs:
English: • quinidine - for abnormal heart rhythms.
Danish: • quinidin - mod unormal hjerterytme
English: Close clinical monitoring should be exercised during administration of PREVYMIS with quinidine.
Danish: Der bør foretages nøje klinisk monitorering under samtidig administration af PREVYMIS og quinidin.
English: • abnormalities in laboratory tests of liver function
Danish: • unormale prøveresultater for leverfunktion
English: Please note that the interaction potential and clinical consequences may be different depending on whether letermovir is administered orally or IV, and whether cyclosporine is concomitantly used.
Danish: Bemærk, at interaktionspotentialet og de kliniske konsekvenser kan være forskellige, afhængigt af om letermovir administreres oralt eller intravenøst og om ciclosporin anvendes samtidigt.
English: In healthy subjects, the geometric mean steady-state AUC and Cmax values were 71,500 ng•hr/mL and 13,000 ng/mL, respectively, with 480 mg once daily oral letermovir.
Danish: Hos raske forsøgspersoner var de geometriske gennemsnitlige AUC- og Cmax-værdier ved steady state henholdsvis 71.500 ng•t/ml og 13.000 ng/ml med 480 mg oralt letermovir en gang dagligt.
English: It is very important that you do not miss or skip doses of PREVYMIS.
Danish: Det er meget vigtigt, at du ikke glemmer at tage eller springer doser af Prevymis over.
English: • thioridazine - for psychiatric disorders
Danish: • thioridazin - mod psykiske forstyrrelser
English: For additional information, see section 4.2.
Danish: 4.2 for yderligere oplysninger.
English: In vitro data indicate that letermovir is an inhibitor of OAT3; therefore, letemovir may be an OAT3 inhibitor in vivo.
Danish: Lægemidler, der transporteres af den renale transportør OAT3 In vitro-data indikerer, at letermovir er en OAT3-hæmmer; derfor kan letermovir være en OAT3hæmmer in vivo.
English: No dose adjustment of PREVYMIS is required based on mild (Child-Pugh Class A) to moderate (Child-Pugh Class B) hepatic impairment.
Danish: Det er ikke nødvendigt at justere dosis af PREVYMIS på baggrund af let nedsat (Child-Pughklasse A) til moderat nedsat (Child-Pugh-klasse B) leverfunktion.
English: This is equivalent to 2.30% of the recommended maximum daily dietary intake of sodium for an adult.
Danish: Dette svarer til 2,30 % af det anbefalede maksimale daglige indtag af natrium for voksne.
English: The mechanism is likely saturation/autoinhibition of OATP1B1/3.
Danish: Mekanismen er sandsynligvis mætning/autohæmning af OATP1B1/3.
English: - Examples of medicinal products metabolised by UGT1A1 are raltegravir and dolutegravir.
Danish: - Eksempler på lægemidler, der metaboliseres af UGT1A1, er raltegravir og dolutegravir.
English: However, Amphotericin B (liposomal) is incompatible (see section 6.2).
Danish: Amphotericin B (liposomalt) er imidlertid inkompatibelt (se pkt.
English: Discard if discolouration or visible particles are observed.
Danish: Kasser infusionsvæsken, hvis der observeres misfarvning eller synlige partikler.
English: Antimycobacterials rifabutin
Danish: Antimykobakterielle midler rifabutin
English: Subjects were randomised (2:1) to receive either letermovir at a dose of 480 mg once daily adjusted to 240 mg when co-administered with cyclosporine, or placebo.
Danish: Forsøgspersonerne blev randomiseret i forholdet 2:1 til at modtage enten letermovir med en dosis på 480 mg en gang dagligt justeret til 240 mg, når det blev administreret samtidigt med ciclosporin, eller placebo.
English: In a Phase 3 trial (P001), DNA sequence analysis of the entire coding regions of UL56 and UL89 was performed on samples obtained from 22 letermovir-treated subjects, in the FAS population who experienced prophylaxis failure and for whom samples were available for analysis.
Danish: I et fase 3-studie (P001) blev der foretaget DNA-sekvensanalyse af de fulde kodningsområder af UL56 og UL89 på prøver indhentet fra 22 letermovir-behandlede forsøgspersoner i det fulde analysesæt (FAS)-populationen, der oplevede profylaksesvigt, og hvis prøver var tilgængelige for analyse.
English: Endothelin antagonists bosentan
Danish: Endothelin-receptorantagonister bosentan
English: Letermovir unbound AUC was approximately 81%- and 4-fold higher in subjects with moderate (Child-Pugh Class B [CP-B], score of 7-9) and severe (Child-Pugh Class C [CP-C], score of 10-15) hepatic impairment, respectively, compared to healthy subjects.
Danish: AUC for ubundet letermovir var ca. 81 % og 4 gange højere hos forsøgspersoner med henholdsvis moderat nedsat (Child-Pugh-klasse B [CP-B], score på 7-9) og svært nedsat (Child-Pugh-klasse C [CP-C], score på 10-15) leverfunktion sammenlignet med raske forsøgspersoner.
English: Subjects were monitored through Week 24 post-transplant for the primary efficacy endpoint with continued follow-up through Week 48 post-transplant.
Danish: Forsøgspersonerne blev monitoreret til og med uge 24 efter transplantation for det primære virkningsmål med fortsat opfølgning til og med uge 48 efter transplantation.
English: Dose adjustment of CYP3A metabolised opioids may be needed
Danish: Dosisjustering af CYP3A-metaboliserede opioider kan være nødvendig
English: Medicinal products metabolised by CYP3A
Danish: Lægemidler, der metaboliseres af CYP3A
English: HIV medicinal products efavirenz
Danish: Hiv-lægemidler efavirenz
English: Do not run out of PREVYMIS.
Danish: Sørg for ikke at løbe tør for Prevymis.
English: In vivo studies are available investigating the net effect on CYP3A4, P-gp, OATP1B1/3 additionally on CYP2C19.
Danish: Der foreligger in vivo-studier, som har undersøgt nettoeffekten på CYP3A4, P-gp, OATP1B1/3 og yderligere på CYP2C19.
English: Expected: ↓omeprazole
Danish: Forventet: ↓ omeprazol
English: After dilution, PREVYMIS should be administered by intravenous infusion via peripheral or central venous catheter using a total time of approximately 60 minutes.
Danish: Efter fortynding skal PREVYMIS administreres som intravenøs infusion via et perifert eller centralt venekateter over et samlet tidsrum på ca. 60 minutter.
English: pantoprazole
Danish: pantoprazol
English: The magnitude of the OATP1B1/3 inhibition on co-administered medicinal products is likely greater when PREVYMIS is co-administered with cyclosporine (a potent OATP1B1/3 inhibitor).
Danish: Omfanget af OATP1B1/3-hæmning på samtidigt administrede lægemidler er sandsynligvis større, når PREVYMIS administreres sammen med ciclosporin (en potent OATP1B1/3-hæmmer).
English: Vacuolation was noted in the kidneys of rats administered IV letermovir formulated with 1500 mg/kg/day of the cyclodextrin excipient hydroxypropylbetadex.
Danish: Vakuolisering blev registreret i nyrerne hos rotter, som fik administreret letermovir intravenøst formuleret med 1.500 mg/kg/dag af cyclodextrinhjælpestoffet hydroxypropylbetadex.
English: If you are taking PREVYMIS with cyclosporine, do not take the following medicines: o dabigatran - used for blood clots o atorvastatin, simvastatin, rosuvastatin, pitavastatin -for high cholesterol
Danish: Hvis du tager Prevymis sammen med ciclosporin, må du ikke tage følgende lægemidler: o dabigatran - anvendes mod blodpropper o atorvastatin, simvastatin, rosuvastatin, pitavastatin - mod forhøjet kolesterol.
English: When PREVYMIS is co-administered with cyclosporine, use of these statins is contraindicated.
Danish: Når PREVYMIS administreres sammen med ciclosporin, er anvendelse af disse statiner kontraindiceret.
English: Conditioning Regimen Myeloablative (n=154, 85)
Danish: Konditioneringsregime Myeloablativt (n=154, 85)
English: Letermovir inhibits the CMV DNA terminase complex which is required for cleavage and packaging of viral progeny DNA.
Danish: Letermovir hæmmer CMV-DNA-terminase-komplekset, der kræves til spaltning og pakning af virusDNA.
English: Risk stratum
Danish: Risikostratum
English: • After dilution, administer PREVYMIS via intravenous infusion via peripheral or central venous catheter using a total time of approximately 60 minutes.
Danish: • Efter fortynding skal Prevymis administreres som intravenøs infusion via et perifert eller centralt venekateter over et samlet tidsrum på ca. 60 minutter.
English: Co-administration of PREVYMIS with voriconazole (a CYP2C19 substrate) results in significantly decreased voriconazole plasma concentrations, indicating that letermovir is an inducer of CYP2C19.
Danish: Samtidig administration af PREVYMIS og voriconazol (et CYP2C19-substrat) resulterer i signifikant nedsat plasmakoncentration af voriconazol, hvilket indikerer, at letermovir er en CYP2C19-induktor.
English: PREVYMIS should be initiated by a physician experienced in the management of patients who have had an allogeneic haematopoietic stem cell transplant.
Danish: Behandlingen med PREVYMIS skal initieres af en læge med erfaring i behandling af patienter, som har gennemgået en allogen hæmatopoietisk stamcelletransplantation.
English: Inducers of drug metabolizing enzymes or transporters Co-administration of PREVYMIS (with or without cyclosporine) with strong and moderate inducers of transporters (e.g., P-gp) and/or enzymes (e.g., UGTs) is not recommended, as it may lead to subtherapeutic letermovir exposure (see Table 1).
Danish: Induktorer af lægemiddelmetaboliserende enzymer eller transportører Administration af PREVYMIS (med eller uden cyclosporin) sammen med stærke og moderate induktorer af transportører (f.eks. P-gp) og/eller enzymer (f.eks. UGTer) anbefales ikke, da det kan medføre subterapeutisk eksponering for letermovir (se tabel 1).
English: Mismatched related (n=52, 18) Matched unrelated (n=122, 70)
Danish: Mismatch beslægtet (n=52, 18) Match ubeslægtet (n=122, 70)
English: - Examples of medicinal products transported by BCRP include rosuvastatin and sulfasalazine.
Danish: - Eksempler på lægemidler, der transporteres af BCRP, er rosuvastatin og sulfasalazin.
English: Type I (30 mL) clear glass vial with a 20 mm fluorocoated chlorobutyl stopper with aluminium flip-off cap containing 12 mL(medium green cap) or 24 mL (dark blue cap) of solution.
Danish: 30 ml klart hætteglas (type I-glas) med en 20 mm fluor-coated chlorbutylprop og en aluminiumshætte med et flip-off-låg, som indeholder 12 ml (mellemgrønt låg) eller 24 ml (mørkeblåt låg) opløsning.
English: Medicinal products metabolised by CYP2C8
Danish: Lægemidler, der metaboliseres af CYP2C8
English: The elimination pathways of letermovir in vivo are biliary excretion and glucuronidation.
Danish: Letermovirs eliminationsveje in vivo er biliær udskillelse og glucuronidering.
English: Subjects had continued follow-up through Week 48 post-transplant.
Danish: Forsøgspersonerne fortsatte opfølgningen til og med uge 48 efter transplantation.
English: Irreversible testicular toxicity was noted only in rats at systemic exposures (AUC) ≥3-fold the exposures in humans at the recommended human dose (RHD).
Danish: Irreversibel testikeltoksicitet blev kun bemærket hos rotter ved systemiske eksponeringer (AUC) ≥ 3 gange eksponeringerne hos mennesker ved den anbefalede dosis til mennesker (RHD).
English: Monitoring of amiodarone concentrations should be performed regularly when amiodarone is co-administered with PREVYMIS
Danish: Der bør foretages hyppig monitorering af amiodaronkoncentrationen, når amiodaron administreres sammen med PREVYMIS
English: Number of Subjects at Risk Letermovir
Danish: Antal forsorsøgspersoner i risikogruppen Letermovir
English: Risk of adverse reactions or reduced therapeutic effect due to medicinal product interactions The concomitant use of PREVYMIS and certain medicinal products may result in known or potentially significant medicinal product interactions, some of which may lead to:
Danish: Samtidig anvendelse af PREVYMIS og visse lægemidler kan resultere i dokumenterede eller potentielt signifikante lægemiddelinteraktioner, hvoraf nogle kan føre til:
English: Do not stop taking PREVYMIS
Danish: Du må ikke holde op med at tage Prevymis
English: Letermovir may decrease the plasma concentrations of CYP2C19 substrates.
Danish: Letermovir kan nedsætte plasmakoncentrationer af CYP2C19substrater.
English: There was no testicular toxicity in rats at exposures (AUC) similar to the exposures in humans at the RHD.
Danish: Der var ingen testikeltoksicitet hos rotter ved eksponeringer (AUC), der var sammenlignelige med eksponeringerne hos mennesker ved RHD.
English: • Inspect vial contents for discolouration and particulate matter prior to dilution.
Danish: • Kontroller hætteglassets indhold for misfarvning og partikler før fortynding.
English: In HSCT recipients, bioavailability of letermovir was estimated to be approximately 35% with 480 mg once daily oral letermovir administered without cyclosporine.
Danish: Hos HSCT-recipienter blev letermovirs biotilgængelighed estimeret til at være ca. 35 % med 480 mg letermovir oralt en gang dagligt administreret uden ciclosporin.
English: In rats, maternal toxicity (including decrease in body weight gain) was noted at 250 mg/kg/day (approximately 11-fold the AUC at the RHD); in the offspring, decreased foetal weight with delayed ossification, slightly oedematous foetuses, and increased incidence of shortened umbilical cords and of variations and malformations in the vertebrae, ribs, and pelvis were observed.
Danish: Hos rotter blev maternel toksicitet (herunder fald i graden af vægtøgning) bemærket ved 250 mg/kg/dag (ca. 11 gange AUC ved RHD); hos afkommet blev der observeret nedsat fostervægt med forsinket ossifikation, let ødematøse fostre og øget incidens af forkortede navlestrenge og af forandringer i og misdannelser af ryghvirvler, ribben og bækken.
English: Letermovir does not prolong QTc to any clinically relevant extent following the 960 mg IV dose with plasma concentrations approximately 2-fold higher than the 480 mg IV dose.
Danish: Letermovir forlænger ikke QTc-intervallet i klinisk relevant grad efter den intravenøse 960 mg dosis, og plasmakoncentrationerne er ca. 2 gange højere end ved den intravenøse 480 mg dosis.
English: Concomitant use is not recommended.
Danish: Samtidig anvendelse anbefales ikke.
English: Close clinical monitoring for respiratory depression and/or prolonged sedation should be exercised during coadministration of PREVYMIS in combination with cyclosporine and alfentanil or fentanyl.
Danish: Der bør foretages nøje klinisk monitorering for respiratorisk depression og/eller langvarig sedation under samtidig administration af PREVYMIS i kombination med ciclosporin og alfentanil eller fentanyl.
English: Intravenous use after dilution Single use only
Danish: Intravenøs anvendelse efter fortynding Kun til engangsbrug
English: In vitro, letermovir is an inhibitor of CYP3A, CYP2C8, CYP2B6, BCRP, UGT1A1, OATP2B1, and OAT3 at in vivo relevant concentrations.
Danish: In vitro er letermovir en hæmmer af CYP3A, CYP2C8, CYP2B6, BCRP, UGT1A1, OATP2B1, og OAT3 ved in vivo-relevante koncentrationer.
English: The primary efficacy endpoint of clinically significant CMV infection in P001 was defined by the incidence of CMV DNAemia warranting anti-CMV pre-emptive therapy (PET) or the occurrence of CMV end-organ disease.
Danish: Det primære virkningsmål for klinisk signifikant CMV-infektion i P001 blev defineret ud fra forekomsten af CMV-DNAæmi, som indicerer præemptiv behandling (PET) mod CMV eller forekomst af CMV-sygdom i målorgan.
English: • fentanyl - for severe pain
Danish: • fentanyl - mod stærke smerter
English: Concomitant use of dabigatran, atorvastatin, simvastatin, rosuvastatin or pitavastatin is contraindicated (see section 4.5).
Danish: Samtidig anvendelse af dabigatran, atorvastatin, simvastatin, rosuvastatin eller pitavastatin er kontraindiceret (se pkt.
English: The mean apparent terminal half-life for letermovir is approximately 12 hours with 480 mg IV letermovir in healthy subjects.
Danish: Letermovirs gennemsnitlige tilsyneladende terminale halveringstid er ca. 12 timer med 480 mg intravenøst letermovir hos raske forsøgspersoner.
English: Frequent monitoring for adverse reactions related to amiodarone is recommended during co-administration.
Danish: Der anbefales hyppig monitorering for bivirkninger relateret til amiodaron under samtidig administration.
English: -Examples of such medicinal products include warfarin, voriconazole, diazepam, lansoprazole, omeprazole, esomeprazole, pantoprazole, tilidine, tolbutamide (see Table 1).
Danish: - Eksempler på sådanne lægemidler er warfarin, voriconazol, diazepam, lansoprazol, omeprazol, esomeprazol, pantoprazol, tilidin, tolbutamid (se tabel 1).
English: The effect of letermovir on doses up to 960 mg given IV on the QTc interval was evaluated in a randomised, single-dose, placebo- and active-controlled (moxifloxacin 400 mg oral) 4-period crossover thorough QT trial in 38 healthy subjects.
Danish: Indvirkningen af letermovir på QTc-intervallet ved doser på op til 960 mg givet intravenøst blev vurderet i et randomiseret, placebo- og aktivkontrolleret (400 mg moxifloxacin givet oralt), tilbundsgående 4-perioders-overkrydsnings-QT-studie med enkeltdoser hos 38 raske forsøgspersoner.
English: In male rats, reduced sperm concentration, reduced sperm motility, and decreased fertility were observed at systemic exposures ≥ 3-fold the AUC in humans at the RHD (see General toxicology).
Danish: Hos hanrotter blev der observeret reduceret sædkoncentration, reduceret sædmotilitet og nedsat fertilitet ved systemiske eksponeringer ≥ 3 gange AUC hos mennesker ved RHD (se Generel toksicitet).
English: • carbamazepine, phenobarbital, phenytoin - for fits or seizures
Danish: • carbamazepin, phenobarbital, phenytoin - mod epileptiske anfald eller krampeanfald
English: (intestinal P-gp induction)
Danish: (intestinal P-gp-induktion)
English: • Anti-thymocyte globulin
Danish: • Antithymocytglobulin
English: • Tigecycline
Danish: Tigecyclin
English: o pimozide - used for Tourette's syndrome o ergot alkaloids (such as ergotamine and dihydroergotamine) - used for migraine headaches.
Danish: • hvis du tager et eller flere af disse lægemidler: o pimozid - anvendes mod Tourettes syndrom o sekalealkaloider (f.eks. ergotamin og dihydroergotamin) - anvendes mod migrænehovedpiner.
English: Concentrate for solution for infusion (sterile concentrate) Clear, colourless liquid pH between 7 and 8
Danish: Klar, farveløs væske pH mellem 7 og 8
English: This medicinal product contains 46 mg (2.0 mmol) sodium per 480 mg vial, equivalent to 2.30% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Danish: Dette lægemiddel indeholder 46 mg (2,0 mmol) natrium pr. 480 mg hætteglas, svarende til 2,30 % af WHO's anbefalede maksimale daglige indtag af natrium på 2 g for voksne.
English: Overall (N=325, 170)
Danish: Samlet (N=325, 170)
English: With NC=F approach, failure was defined as all subjects with clinically significant CMV infection or who prematurely discontinued from the study or had a missing outcome through Week 24 post-transplant visit window.
Danish: Med NC = Fmetoden blev failure defineret som alle forsøgspersoner med klinisk signifikant CMV-infektion eller som udgik af studiet før tid eller havde et manglende resultat ved besøget i uge 24 efter transplantation.
English: • allergic reaction (hypersensitivity) - the signs may include wheezing, difficulty breathing, rashes or hives, itchiness, swelling.
Danish: • allergisk reaktion (overfølsomhed) - symptomerne kan omfatte hvæsende vejrtrækning,
English: Based on population pharmacokinetic analyses, letermovir steady-state apparent CL is estimated to be 4.84 L/hr following intravenous administration of 480 mg in HSCT recipients.
Danish: På basis af farmakokinetiske populationsanalyser estimeres letermovirs tilsyneladende clearance ved steady state at være 4,84 l/t efter intravenøs administration af 480 mg hos HSCT-recipienter.
English: However, caution is advised if P-gp/BCRP inhibitors are added to letermovir combined with cyclosporine.
Danish: Der skal dog udvises forsigtighed, hvis P-gp-/BCRP-hæmmere tilføjes til letermovir-regimer i kombination med ciclosporin.
English: Letermovir may increase or decrease the plasma concentrations of repaglinide.
Danish: Letermovir kan øge eller nedsætte plasmakoncentrationerne af repaglinid.
English: • Fluconazole
Danish: Fluconazol