FrancophonIA/ELRC3.0 huggingface dataset:
English: The recommended treatment durations vary and national or local guidelines should be taken into consideration.
Croatian: Preporučeno trajanje liječenja je različito pa u obzir treba uzeti nacionalne ili lokalne smjernice.
English: the heart.
Croatian: • srca.
English: The elimination half-life of total ceftriaxone in adults is about 8 hours.
Croatian: Poluvrijeme eliminacije ukupnog ceftriaksona u odraslih iznosi približno 8 sati.
English: The doctor will consider the benefit of treating you with Rocephin against the risk to your baby.
Croatian: Liječnik će razmotriti koristi liječenja lijekom Rocephin za Vas u odnosu na rizike za Vaše dijete.
English: If you are given more Rocephin than you should
Croatian: Ako primite više lijeka Rocephin nego što ste trebali
English: Rocephin may be used:
Croatian: Rocephin se može koristiti:
English: Interaction with calcium containing products
Croatian: Interakcija s proizvodima koji sadrže kalcij
English: Commonly susceptible species
Croatian: Vrste koje su obično osjetljive
English: Other medicines and Rocephin
Croatian: Drugi lijekovi i Rocephin
English: • An antibiotic called chloramphenicol (used to treat infections, particularly of the eyes).
Croatian: • antibiotik koji se zove kloramfenikol (koristi se za liječenje infekcija, osobito infekcija oka).
English: Symptomatic treatment is recommended in these cases.
Croatian: U tim se slučajevima preporučuje simptomatsko liječenje.
English: Gram-positive aerobes
Croatian: Gram-pozitivni aerobi
English: This effect is usually asymptomatic, but the precipitations have been accompanied by clinical symptoms such as pain, nausea and vomiting in rare cases.
Croatian: Taj je učinak obično asimptomatski, no precipitacije su u rijetkim slučajevima pratili klinički simptomi poput boli, mučnine i povraćanja.
English: Binding is saturable and the bound portion decreases with rising concentration (up to 85 % at a plasma concentration of 300 mg/l).
Croatian: Vezanje je saturabilno, a udio vezanog lijeka smanjuje se s povećanjem koncentracije (do 85% pri koncentraciji u plazmi od 300 mg/l).
English: the middle ear.
Croatian: • srednjeg uha
English: • You are allergic to ceftriaxone or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični na ceftriakson ili bilo koji drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: • hydrolysis by beta-lactamases, including extended-spectrum beta-lactamases (ESBLs),
Croatian: • hidrolize posredovane beta-laktamazama, uključujući beta-laktamaze proširenog spektra,
English: • 1 to 2 g once a day depending on the severity and type of infection.
Croatian: • 1 do 2 g jedanput na dan, ovisno o težini i vrsti infekcije.
English: It can be given as a drip (intravenous infusion) or as an injection directly into a vein or into a muscle.
Croatian: Može se dati ukapavanjem (infuzijom u venu) ili injekcijom izravno u venu ili mišić.
English: As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of ceftriaxone in at least some types of infections is questionable.
Croatian: Prema potrebi treba potražiti savjet stručnjaka ako je lokalna prevalencija rezistencije takva da je korist ceftriaksona upitna barem u nekim vrstama infekcija.
English: • to treat infections of the chest in adults with chronic bronchitis.
Croatian: • liječenje infekcija prsnog koša u odraslih s kroničnim bronhitisom
English: At least one of them had received ceftriaxone and calcium at different times and through different intravenous lines.
Croatian: Barem jedno od njih primilo je ceftriakson i kalcij u različito vrijeme i kroz različite intravenske linije.
English: In children, prospective studies have shown a variable incidence of precipitation with intravenous application - above 30 % in some studies.
Croatian: Prospektivna ispitivanja ukazala su na varijabilnu incidenciju precipitacije kod intravenske primjene u djece - u nekim je ispitivanjima ona bila veća od 30%.
English: Protein binding
Croatian: Vezanje za proteine
English: Intravenous doses of 50 mg/kg or more in infants and children up to 12 years of age should be given by infusion.
Croatian: Intravenske doze od 50 mg/kg ili više u dojenčadi i djece u dobi do 12 godina treba primjenjivati infuzijom.
English: What Rocephin is and what it is used for
Croatian: Što je Rocephin i za što se koristi
English: • outer membrane impermeability in Gram-negative organisms.
Croatian: • nepropusnosti vanjske membrane u gram-negativnih organizama
English: Intramuscular injections should be injected well within the bulk of a relatively large muscle and not more than 1 g should be injected at one site.
Croatian: Intramuskularne injekcije treba injicirati duboko u relativno velik mišić, ali na jednom se mjestu ne smije injicirati više od 1 g.
English: Rocephin is an antibiotic given to adults and children (including newborn babies).
Croatian: Rocephin je antibiotik koji se daje odraslim osobama i djeci (uključujući novorođenčad).
English: Intravenous intermittent injection should be given over 5 minutes preferably in larger veins.
Croatian: Intravensku intermitentnu injekciju treba primjenjivati tijekom 5 minuta, po mogućnosti u veće vene.
English: What you need to know before you are given Rocephin
Croatian: Što morate znati prije nego počnete primati Rocephin
English: A maximum daily dose of 50 mg/kg should not be exceeded.
Croatian: Ne smije se premašiti maksimalna dnevna doza od 50 mg/kg.
English: The plasma clearance and volume of distribution of total ceftriaxone are greater in neonates, infants and children than in adults.
Croatian: Klirens iz plazme i volumen distribucije ukupnog ceftriaksona veći su u novorođenčadi, dojenčadi i djece nego u odraslih osoba.
English: If your daily dose is higher than 2 g, you may receive it as a single dose once a day or as two separate doses.
Croatian: Ako je dnevna doza veća od 2 g, možda ćete je primiti kao jednu dozu jedanput na dan ili kao dvije zasebne doze.
English: Rocephin can be administered by intravenous infusion over at least 30 minutes (preferred route) or by slow intravenous injection over 5 minutes, or by deep intramuscular injection.
Croatian: Rocephin se može primijeniti intravenskom infuzijom tijekom najmanje 30 minuta (preporučeni put primjene) ili sporom intravenskom injekcijom tijekom 5 minuta, ili dubokom intramuskularnom injekcijom.
English: Penetration into particular tissues
Croatian: Prodiranje u određena tkiva
English: If you have a severe infection, your doctor will give you a higher dose up to 100 mg for each kg of body weight to a maximum of 4 g once a day.
Croatian: Ako dijete ima tešku infekciju, liječnik će dati veću dozu od najviše 100 mg po kg tjelesne težine, do maksimalnih 4 g jedanput na dan.
English: From birth to 14 days of age, the levels of free ceftriaxone may be further increased by factors such as reduced glomerular filtration and altered protein binding.
Croatian: Od rođenja do 14 dana starosti koncentracije slobodnog ceftriaksona mogu dodatno povećati faktori poput smanjene glomerularne filtracije i izmijenjena vezanja za proteine.
English: Concentrations for the intravenous injection: 100 mg/ml, Concentrations for the intravenous infusion: 50 mg/ml (Please refer to section 4.2 for further information).
Croatian: <i druga rukovanja lijekom> Koncentracije za intravensku injekciju: 100mg/ml Koncentracije za intravensku infuziju: 50 mg/ml (Molimo vidjeti dio 4.2 za dodatne informacije).
English: Your doctor will decide how much Rocephin you will need and will check you closely depending on the severity of the liver and kidney disease.
Croatian: Liječnik će odlučiti koliko Vam lijeka Rocephin treba te će Vas pažljivo nadzirati u skladu s težinom jetrene i bubrežne bolesti.
English: Severe cases of haemolytic anaemia, including fatalities, have been reported during Rocephin treatment in both adults and children.
Croatian: Teški slučajevi hemolitičke anemije, uključujući smrtne slučajeve, prijavljeni su tijekom liječenja lijekom Rocephin i u odraslih i u djece.
English: • bacterial efflux pumps.
Croatian: • bakterijske efluks pumpe.
English: Ceftriaxone is reversibly bound to albumin.
Croatian: Ceftriakson se reverzibilno veže za albumin.
English: Italy: Rocefin
Croatian: Italija: Rocefin
English: There is evidence from animal studies that high doses of ceftriaxone calcium salt led to formation of concrements and precipitates in the gallbladder of dogs and monkeys, which proved to be reversible.
Croatian: Postoje dokazi iz istraživanja na životinjama koji pokazuju da visoke doze ceftriakson-soli kalcija dovode do stvaranja konkremenata i precipitata u žučnom mjehuru pasa i majmuna, a pojava je reverzibilna.
English: Gram-negative aerobes
Croatian: Gram-negativni aerobi
English: Severe cutaneous adverse reactions (Stevens Johnson syndrome or Lyell's syndrome/toxic epidermal necrolysis) have been reported; however, the frequency of these events is not known (see section 4.8).
Croatian: Prijavljene su teške kožne nuspojave (Stevens-Johnsonov sindrom ili Lyellov sindrom/toksična epidermalna nekroliza); međutim, učestalost tih nuspojava nije poznata (vidjeti dio 4.8).
English: For doses greater than 2 g intravenous administration should be used.
Croatian: Za doze veće od 2 g mora se koristiti intravenska primjena.
English: • to prevent infections during surgery.
Croatian: • sprječavanje infekcija tijekom kirurškog zahvata
English: Cases of renal precipitation have been reported, primarily in children older than 3 years of age and who have been treated with either high daily doses (e.g. ≥ 80 mg/kg/day) or total doses exceeding 10 grams and who presented with other risk factors (e.g. fluid restrictions or confinement to bed).
Croatian: Prijavljeni su slučajevi bubrežne precipitacije, prvenstveno u djece starije od 3 godine koja su liječena ili visokim dnevnim dozama (npr. ≥ 80 mg/kg/dan) ili ukupnim dozama većima od 10 mg i koja su imala neke druge faktore rizika (npr. Smanjeni unos tekućine ili imobilizaciju).
English: Only in cases of preterminal renal failure (creatinine clearance < 10 ml/min) should the ceftriaxone dosage not exceed 2 g daily.
Croatian: Samo u slučajevima preterminalnog zatajenja bubrega (klirens kreatinina < 10 ml/min) doza ceftriaksona ne smije biti veća od 2 g na dan.
English: The dose will depend on the severity and type of infection; whether you are on any other antibiotics; your weight and age; how well your kidneys and liver are working.
Croatian: Doza će ovisiti o težini i vrsti infekcije; o tome primate li neke druge antibiotike; o Vašoj tjelesnoj težini i dobi; o tome koliko dobro Vam rade bubrezi i jetra.
English: There are no study data in patients with severe hepatic impairment (see section 5.2).
Croatian: Nema podataka iz ispitivanja u bolesnika s teškim oštećenjem jetrene funkcije (vidjeti dio 5.2).
English: Each gram of Rocephin contains 3.6 mmol sodium.
Croatian: Jedan gram lijeka Rocephin sadrži 3,6 mmol natrija.
English: You are allergic to lidocaine and you are to be given Rocephin as an injection into a muscle.
Croatian: • ako ste alergični na lidokain, a trebate primite Rocephin injekcijom u mišić.
English: • The maximum daily dose is not to be more than 50 mg for each kg of the baby's weight.
Croatian: • Maksimalna dnevna doza ne smije biti veća od 50 mg po kilogramu tjelesne težine djeteta.
English: • You have had a sudden or severe allergic reaction to penicillin or similar antibiotics (such as cephalosporins, carbapenems or monobactams).
Croatian: • ako ste ikada imali naglu ili tešku alergijsku reakciju na penicilin ili slične antibiotike (poput cefalosporina, karbapenema ili monobaktama).
English: Animal studies produced no evidence of toxicity to reproduction and genotoxicity.
Croatian: Istraživanja na životinjama nisu ukazala na reproduktivnu toksičnost niti na genotoksičnost.
English: Rocephin is made up by the doctor, pharmacist or nurse and will not be mixed with or given to you at the same time as calcium-containing injections.
Croatian: Rocephin će za primjenu pripremiti liječnik, ljekarnik ili medicinska sestra, a neće se miješati niti davati istodobno s injekcijama koje sadrže kalcij.
English: Based on literature reports, ceftriaxone is not compatible with amsacrine, vancomycin, fluconazole and aminoglycosides.
Croatian: Na temelju podataka iz literature, ceftriakson nije kompatibilan s amsakrinom, vankomicinom, flukonazolom ni aminoglikozidima.
English: Talk to your doctor or pharmacist or nurse before you are given Rocephin if:
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego primite Rocephin:
English: Ceftriaxone has a limited spectrum of antibacterial activity and may not be suitable for use as a single agent for the treatment of some types of infections unless the pathogen has already been confirmed (see section 4.2).
Croatian: Ceftriakson ima ograničen spektar antibakterijskog djelovanja pa možda neće biti prikladan kao monoterapija za liječenje nekih vrsta infekcija, osim ako patogen već nije potvrđen (vidjeti dio 4.2).
English: This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.
Croatian: To dovodi do prekida biosinteze stanične stijenke (peptidoglikana), što uzrokuje lizu i smrt bakterijske stanice.
English: Simultaneous administration of probenecid does not reduce the elimination of ceftriaxone.
Croatian: Istodobna primjena probenecida ne smanjuje eliminaciju ceftriaksona.
English: Uncommon (≥ 1/1000 - < 1/100) Rare (≥ 1/10000 - < 1/1000)
Croatian: često (≥ 1/100 - < 1/10) manje često (≥ 1/1000 - < 1/100) rijetko (≥ 1/10 000 - < 1/1000) nepoznato (ne može se procijeniti iz dostupnih podataka)
English: Streptococcus pyogenes (Group A) Streptococcus agalactiae (Group B) Streptococcus pneumoniae Viridans Group Streptococci
Croatian: Streptococcus pyogenes (skupina A) Streptococcus agalactiae (skupina B) Streptococcus pneumoniae streptokoki iz skupine Viridans
English: During prolonged treatment complete blood count should be performed at regular intervals.
Croatian: Dugotrajno liječenje Tijekom dugotrajnog liječenja treba redovito kontrolirati kompletnu krvnu sliku.
English: In neonates, intravenous doses should be given over 60 minutes to reduce the potential risk of bilirubin encephalopathy (see section 4.3 and 4.4).
Croatian: U novorođenčadi, intravenske doze treba primjenjivati tijekom 60 minuta kako bi se smanjio mogući rizik od bilirubinske encefalopatije (vidjeti dijelove 4.3 i 4.4).
English: Rocephin is indicated for the treatment of the following infections in adults and children including term neonates (from birth):
Croatian: Rocephin je indiciran za liječenje sljedećih infekcija u odraslih i djece, uključujući novorođenčad rođenu u terminu (od rođenja):
English: As with antibiotic therapy in general, administration of ceftriaxone should be continued for 48 - 72 hours after the patient has become afebrile or evidence of bacterial eradication has been achieved.
Croatian: Kao i kod drugih antibiotika, primjenu ceftriaksona treba nastaviti još 48-72 sata nakon što bolesnik postane afebrilan ili se utvrdi postizanje eradikacije bakterija.
English: • A neurological condition that may occur in neonates with severe jaundice (kernicterus).
Croatian: • neurološko stanje koje se može javiti u novorođenčadi s teškom žuticom (kernikterus)
English: 50 - 60 % of ceftriaxone is excreted unchanged in the urine, primarily by glomerular filtration, while 40 - 50 % is excreted unchanged in the bile.
Croatian: 50-60% ceftriaksona izlučuje se u nepromijenjenu obliku u mokraći, prvenstveno glomerularnom filtracijom, a 40-50% izlučuje se u neizmijenjenu obliku putem žuči.
English: It belongs to a group of medicines called cephalosporins.
Croatian: Pripada skupini lijekova koji se zovu cefalosporini.
English: • A type of antibiotic called an aminoglycoside.
Croatian: • vrstu antibiotika koji se zove aminoglikozid
English: Intramuscular administration should be considered when the intravenous route is not possible or less appropriate for the patient.
Croatian: Intramuskularnu primjenu treba razmotriti kada lijek nije moguće primijeniti intravenski ili kada je intravenski put primjene manje prikladan za bolesnika.
English: Renal clearance is 5 - 12 ml/min.
Croatian: Bubrežni klirens iznosi 5-12 ml/min.
English: Safety and effectiveness of Rocephin in neonates, infants and children have been established for the dosages described under Posology and Method of Administration (see section 4.2).
Croatian: Sigurnost i djelotvornost lijeka Rocephin u novorođenčadi, dojenčadi i djece ustanovljene su za doze opisane u dijelu 'Doziranje i način primjene' (vidjeti dio 4.2).
English: Syphilis
Croatian: Sifilis
English: In polymicrobial infections, where suspected pathogens include organisms resistant to ceftriaxone, administration of an additional antibiotic should be considered.
Croatian: U slučaju polimikrobnih infekcija, kod kojih suspektni patogeni uključuju mikroorganizme rezistentne na ceftriakson, treba razmotriti primjenu još jednog antibiotika.
English: As with all beta-lactam antibacterial agents, serious and occasionally fatal hypersensitivity reactions have been reported (see section 4.8).
Croatian: Kao i kod svih drugih beta-laktamskih antibiotika, prijavljene su ozbiljne reakcije preosjetljivosti koje su ponekad imale smrtni ishod (vidjeti dio 4.8).
English: • Difficulty in breathing (bronchospasm).
Croatian: • otežano disanje (bronhospazam)
English: For treatment of acute exacerbations of chronic obstructive pulmonary disease in adults For treatment of disseminated Lyme borreliosis (early (stage II) and late (stage III)) in adults and children including neonates from 15 days of age
Croatian: Za liječenje akutnih egzacerbacija kronične opstruktivne plućne bolesti u odraslih Za liječenje diseminirane lajmske borelioze (rane (stadij II) i kasne (stadij III)) u odraslih i djece, uključujući novorođenčad stariju od 15 dana
English: * In vitro studies have shown that ceftriaxone can displace bilirubin from its serum albumin binding sites leading to a possible risk of bilirubin encephalopathy in these patients.
Croatian: *In vitro ispitivanja pokazala su da ceftriakson može izmjestiti bilirubin s mjesta njegova vezivanja za albumin u serumu, što može dovesti do rizika od bilirubinske encefalopatije u tih bolesnika.
English: Non-linearity is due to saturation of plasma protein binding and is therefore observed for total plasma ceftriaxone but not for free (unbound) ceftriaxone.
Croatian: Nelinearnost je posljedica zasićenja vezanja za proteine u plazmi i stoga je primijećena kod ukupnog ceftriaksona u plazmi, ali ne i kod slobodnog (nevezanog) ceftriaksona.
English: In particularly severe cases, doses at the higher end of the recommended range should be considered.
Croatian: U izuzetno teškim slučajevima treba razmotriti primjenu doza u gornjem dijelu preporučenog raspona.
English: In the treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above
Croatian: Liječenje bolesnika s bakterijemijom koja je povezana, ili se sumnja da je povezana, s bilo kojom od gore navedenih infekcija.
English: Interference with Coombs tests may occur, as Rocephin may lead to false-positive test results.
Croatian: Može doći do interferencije s Coombsovim testovima jer Rocephin može izazvati lažno pozitivan nalaz.
English: Plasma protein binding is about 95 % at plasma concentrations below 100 mg/l.
Croatian: Vezanje za proteine u plazmi iznosi približno 95% pri koncentracijama u plazmi manjima od 100 mg/l.
English: • A false positive result in a Coombs' test (a test for some blood problems).
Croatian: • lažno pozitivan nalaz Coombsova testa (testa za utvrđivanje određenih krvnih problema)
English: Anaerobes
Croatian: Anaerobi
English: The maximum plasma concentration after a single intramuscular dose of 1 g is about 81 mg/l and is reached in 2 - 3 hours after administration.
Croatian: Maksimalna koncentracija u plazmi nakon jedne intramuskularne doze od 1 g iznosi približno 81 mg/l, a postiže se 2-3 sata nakon primjene.
English: Plasma clearance of total ceftriaxone (bound and unbound) is 10 - 22 ml/min.
Croatian: Eliminacija Plazmatski klirens ukupnog ceftriaksona (vezanog i nevezanog) iznosi 10-22 ml/min.
English: For pre-operative prophylaxis of surgical site infections, ceftriaxone should be administered 30-90 minutes prior to surgery.
Croatian: Za prijeoperacijsku profilaksu infekcija na mjestu kirurškog zahvata ceftriakson treba primijeniti 30-90 minuta prije kirurškog zahvata.
English: The signs include sudden swelling of the throat or face which might make it difficult to breath or swallow, sudden swelling of the hands, feet and ankles, and a severe rash that develops quickly.
Croatian: Znakovi uključuju iznenadno oticanje grla ili lica, koje može otežati disanje ili gutanje, iznenadno oticanje šaka, stopala i gležnjeva te težak osip koji se brzo razvija.
English: In case of severe hypersensitivity reactions, treatment with ceftriaxone must be discontinued immediately and adequate emergency measures must be initiated.
Croatian: U slučaju teških reakcija preosjetljivosti mora se odmah prekinuti primjena ceftriaksona i uvesti odgovarajuće mjere hitnog liječenja.
English: • to treat patients with low white blood cell counts (neutropenia) who have fever due to bacterial infection.
Croatian: • liječenje bolesnika s niskim brojem bijelih krvnih stanica (neutropenija) koji imaju vrućicu uzrokovanu bakterijskom infekcijom
English: The pharmacokinetics of ceftriaxone are non-linear and all basic pharmacokinetic parameters, except the elimination half-life, are dose dependent if based on total drug concentrations, increasing less than proportionally with dose.
Croatian: Farmakokinetika ceftriaksona je nelinearna, a svi osnovni farmakokinetički parametri, osim poluvijeka eliminacije, ovise o dozi ako se temelje na ukupnim koncentracijama lijeka, pa je njihovo povećanje manje od proporcionalnog u odnosu na povećanje doze.
English: Reproductive studies have shown no evidence of adverse effects on male or female fertility.
Croatian: Ispitivanja učinaka lijeka na reprodukciju nisu ukazala ni na kakve štetne učinke na plodnost muškaraca ni žena.
English: c. Isolates with a ceftriaxone MIC above the susceptible breakpoint are rare and, if found, should be re tested and, if confirmed, should be sent to a reference laboratory.
Croatian: c. Izolati u kojih je MIK ceftriaksona iznad granične vrijednosti za osjetljivost su rijetki; ako se takvi izolati pronađu, treba ih ponovno testirati i u slučaju pozitivnog nalaza poslati u referentni laboratorij.
English: Peak ceftriaxone concentrations in CSF are reached approximately 4-6 hours after intravenous injection.
Croatian: Vršne koncentracije ceftriaksona u cerebrospinalnoj tekućini postižu se približno 4-6 sati nakon intravenske injekcije.
English: Rocephin can also lead to false-positive test results for galactosaemia (see section 4.8).
Croatian: Rocephin također može izazvati lažno pozitivan nalaz testa na galaktozemiju (vidjeti dio 4.8).
English: Ceftriaxone is not metabolised systemically; but is converted to inactive metabolites by the gut flora.
Croatian: Ceftriakson se ne metabolizira sistemski, već ga crijevna flora pretvara u neaktivne metabolite.
English: Ceftriaxone crosses the placental barrier.
Croatian: Ceftriakson prolazi kroz placentarnu barijeru.
English: Borrelia burgdorferi Haemophilus influenzae Haemophilus parainfluenzae Moraxella catarrhalis Neisseria gonorrhoea Neisseria meningitidis Proteus mirabilis Providencia spp.
Croatian: Borrelia burgdorferi Haemophilus influenzae Haemophilus parainfluenzae Moraxella catarrhalis Neisseria gonorrhoea Neisseria meningitidis Proteus mirabilis
English: An 8 - 15 % increase in mean peak plasma concentration (Cmax) is seen on repeated administration; steady state is reached in most cases within 48 - 72 hours depending on the route of administration.
Croatian: Nakon primjene ponovljenih doza primijećeno je povećanje srednje vrijednosti vršne koncentracije u plazmi (Cmax) od 8-15%; stanje dinamičke ravnoteže u većini se slučajeva postiže unutar 48-72 sata, ovisno o putu primjene.
English: the blood.
Croatian: • krvi