FrancophonIA/ELRC3.0 huggingface dataset:
English: Use in children of 2 years of age and above
Slovenian: Uporaba pri otrocih, starih 2 leti in več
English: Read all of this leaflet carefully before you start taking this medicine because it contains important information for you or your child. - Keep this leaflet.
Slovenian: Pred začetkom jemanja natančno preberite navodilo, ker vsebuje za vas ali vašega otroka pomembne podatke!
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1000 to < 1/100) and not known (cannot be estimated from the available data).
Slovenian: V razvrstitvah pogostnosti so neželeni učinki navedeni po padajoči resnosti: zelo pogosti (> 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100) in neznana pogostnost (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti).
English: For storage conditions after first opening of the medicinal product, see section 6.3.
Slovenian: Za shranjevanje zdravila po prvem odprtju vsebnika glejte poglavje 6.3.
English: No special requirements.
Slovenian: Ni posebnih zahtev za odstranjevanje.
English: The clinical significance of reduced abacavir and zidovudine concentrations is unknown.
Slovenian: Klinični pomen zmanjšane koncentracije abakavirja in zidovudina ni znan.
English: Sedatives/hypnotics
Slovenian: Sedativi/ hipnotiki
English: Lopinavir: ↔ (relative to historical comparison)
Slovenian: lopinavir: ↔ (v primerjavi z retrospektivno primerjavo)
English: There are limited pharmacokinetic data in children below 2 years of age.
Slovenian: Farmakokinetični podatki pri otrocih do 2. leta starosti so omejeni.
English: − Always keep enough lopinavir/ritonavir on hand so you don't run out.
Slovenian: - Vedno imejte pri roki dovolj lopinavirja/ritonavirja, da vam ga ne bo zmanjkalo.
English: Virologic Response of Study Subjects at Week 48 and Week 96 Week 48
Slovenian: Virološk i odziv preiskovancev v študiji po 48 in 96 tednih 48. teden
English: The increased digoxin level may lessen over time as Pgp induction develops.
Slovenian: Povečana koncentracija digoksina se sčasoma lahko zmanjša, ko se razvije indukcija Pgp.
English: * n = 18 for Cmax ** n = 16 for Cpredose
Slovenian: * n = 18 za Cmax
English: Studies in rats revealed that lopinavir is excreted in the milk.
Slovenian: Dojenje Študije pri podganah so pokazale, da se lopinavir izloča v mleku.
English: Pharmacotherapeutic group: antivirals for systemic use, antivirals for treatment of HIV infections, combinations, ATC code: J05AR10
Slovenian: Farmakoterapevtska skupina: protivirusne učinkovine za sistemsko uporabo, protivirusne učinkovine za zdravljenje okužb s HIV, kombinacije, oznaka ATC: J05AR10
English: The dose increase did not result in a significant increase in the plasma lopinavir concentration.
Slovenian: Povečanje odmerka ni povzročilo pomembnega povečanja plazemske koncentracije lopinavirja.
English: − It is recommended that HIV-infected women do not breast-feed their infants because there is a possibility that the baby can be infected with HIV through your breast milk.
Slovenian: - Priporočeno je, da z virusom HIV okužene ženske ne dojijo, ker se otrok lahko z materinim mlekom okuži z virusom HIV.
English: Treatment of overdose with lopinavir/ritonavir is to consist of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient.
Slovenian: Zdravljenje prevelikega odmerjanja lopinavirja/ritonavirja mora obsegati splošne podporne ukrepe, vključno z nadziranjem vitalnih znakov in opazovanjem bolnikovega kliničnega stanja.
English: Do not drive a car or operate machinery if you experience any side effects (e.g. nausea) that impact your ability to do so safely.
Slovenian: Ne vozite in ne upravljajte s stroji, če se vam pojavi katerikoli neželeni učinek (npr. siljenje na bruhanje), ki bi vplival na vaše varno ravnanje.
English: Since these patients had not previously been exposed to either lopinavir/ritonavir or efavirenz, part of the response may be attributed to the antiviral activity of efavirenz, particularly in patients harbouring highly lopinavir resistant virus.
Slovenian: Ker ti bolniki predhodno niso bili izpostavljeni niti lopinavirju/ritonavirju niti efavirenzu, je del odziva mogoče pripisati protivirusni dejavnosti efavirenza, zlasti pri bolnikih, ki so imeli proti lopinavirju zelo odporen virus.
English: This may result in lowered plasma concentrations and potential decrease of efficacy of co-administered medicinal products.
Slovenian: To lahko zmanjša plazemske koncentracije in potencialno zmanjša učinkovitost sočasno uporabljenih zdravil.
English: Postpartum n = 17**
Slovenian: Po porodu n = 17**
English: Mylan SAS 117 Allee des Parcs 69800 Saint-Priest France
Slovenian: 117 Allee des Parcs 69 800 Saint Priest Francija
English: Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Slovenian: - Preobčutljivost na zdravilni učinkovini ali katerokoli pomožno snov, navedeno v poglavju 6.1.
English: Dieselweg 25, 3752 Bunschoten The Netherlands
Slovenian: Dieselweg 25, 3752 Bunschoten Nizozemska
English: When you travel or need to stay in the hospital make sure you will have enough lopinavir/ritonavir to last until you can get a new supply.
Slovenian: Če greste na potovanje ali v bolnišnico, imejte s seboj vedno toliko lopinavirja/ritonavirja, da vam bo zadostovalo, dokler ne dobite nove zaloge.
English: (combinations of mechanisms including CYP3A inhibition)
Slovenian: (kombinacije mehanizmov, vključno z inhibicijo CYP3A)
English: Diarrhoea, nausea and vomiting may occur at the beginning of the treatment while hypertriglyceridaemia and hypercholesterolemia may occur later.
Slovenian: Driska, navzea in bruhanje se lahko pojavijo v začetku zdravljenja, medtem ko se hipertrigliceridemija in hiperholesterolemija lahko pojavita kasneje.
English: Lopinavir/ritonavir may cause changes in your heart rhythm and the electrical activity of your heart.
Slovenian: Lopinavir/ritonavir lahko povzroči spremembe srčnega ritma in električne aktivnosti srca.
English: Further stratification within each group was 1:1 (tablet versus.
Slovenian: Dodatna stratifikacija znotraj posamezne skupine je bila narejena v razmerju 1:1 (tablete v primerjavi z mehkimi kapsulami).
English: Treatment emergent adverse events led to premature study discontinuation for 7% of subjects from Phase II-IV studies.
Slovenian: Hudi neželeni učinki, ki so se pojavili med zdravljenjem, so vodili do predčasne prekinitve terapije pri 7% bolnikov v študijah faze II doIV.
English: Fluvastatin or Pravastatin Fluvastatin, Pravastatin: No clinical relevant interaction expected.
Slovenian: fluvastatin ali pravastatin fluvastatin, pravastatin: klinično pomembnih medsebojnih delovanj ni pričakovati.
English: − For children, your doctor will decide the right dose (number of tablets) based on the child's height and weight.
Slovenian: - Pravi odmerek (število tablet) za otroka bo zdravnik določil na osnovi otrokove višine in telesne mase.
English: Lopinavir is an inhibitor of the HIV-1 and HIV-2 proteases.
Slovenian: Lopinavir je zaviralec proteaz HIV-1 in HIV-2.
English: In post-marketing surveillance through the Antiretroviral Pregnancy Registry, established since January 1989, an increased risk of birth defects exposures with lopinavir/ritonavir has not been reported among over 1000 women exposed during the first trimester.
Slovenian: V nadzoru v obdobju trženja s pomočjo Protiretrovirusnega nosečnostnega registra, ki je vzpostavljen od januarja 1989, niso poročali o povečanem tveganju prirojenih napak med 1000 ženskami, ki so bile izpostavljene v prvem trimesečju.
English: The pharmacokinetic properties of lopinavir co-administered with ritonavir have been evaluated in healthy adult volunteers and in HIV-infected patients; no substantial differences were observed between the two groups.
Slovenian: Farmakokinetične lastnosti lopinavirja, uporabljenega hkrati z ritonavirjem, so ocenili pri zdravih odraslih prostovoljcih in pri bolnikih, okuženih z virusom HIV; med skupinama niso opazili bistvenih razlik.
English: Do not take Lopinavir/Ritonavir Mylan if: - you are allergic to lopinavir, ritonavir or any of the other ingredients of this medicine (listed in section 6); - you have severe liver problems.
Slovenian: Ne jemljite zdravila Lopinavir/ritonavir Mylan, če: - ste alergični na lopinavir, ritonavir ali katerokoli drugo sestavino tega zdravila (navedeno v poglavju 6); - imate hude težave z jetri.
English: − The usual adult dose is 400 mg/100 mg twice a day i.e. every 12 hours, in combination with other antiHIV medicines.
Slovenian: - Običajni odmerek za odrasle je 400 mg/100 mg dvakrat na dan, to je vsakih 12 ur, v kombinaciji z drugimi zdravili proti okužbam z virusom HIV.
English: If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please inform your doctor or pharmacist.
Slovenian: Če katerikoli neželeni učinek postane resen ali če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite zdravnika ali farmacevta.
English: The combination may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations and sinus tachycardia.
Slovenian: Kombinacija lahko poveča tveganje za srčno-žilne neželene učinke, povezane s salmeterolom, vključno s podaljšanjem QT, palpitacijami in sinusno tahikardijo.
English: HIV-1 isolates with reduced susceptibility to lopinavir have been selected in vitro.
Slovenian: Izolati virusa HIV-1 z zmanjšano občutljivostjo za lopinavir so bili izbrani in vitro.
English: All interaction studies, when otherwise not stated, were performed using lopinavir/ritonavir capsules, which gives an approximately 20% lower exposure of lopinavir than the 200/50 mg tablets.
Slovenian: Vse študije interakcij, če ni drugače navedeno, so bile izvedene z uporabo zdravila lopinavir/ritonavir kapsule, kar pomeni za približno 20 % nižjo izpostavljenost lopinavirju kot pri 200 mg/50 mg tabletah.
English: Lopinavir/ritonavir has not specifically been tested for its possible effects on the ability to drive a car or operate machines.
Slovenian: Lopinavirja/ritonavirja niso posebej preizkušali glede možnih učinkov na sposobnost za upravljanje vozil ali delo s stroji.
English: − Breast-feeding mothers should not take lopinavir/ritonavir unless specifically directed by the doctor.
Slovenian: - Doječe matere ne smejo jemati lopinavirja/ritonavirja, razen če jim tega posebej ne naroči zdravnik.
English: No pattern of birth defects suggestive of a common etiology was seen.
Slovenian: V skupni etilogiji niso opazili vzorca prirojenih napak.
English: A limited increase in total lopinavir concentrations of approximately 30% has been observed which is not expected to be of clinical relevance (see section 4.2).
Slovenian: Opazili so omejeno povečanje koncentracij lopinavirja za približno 30 %, kar ni pričakovati, da bi bilo klinično pomembno (glejte poglavje 4.2).
English: − Tell your doctor immediately if you are planning to have a baby, you are pregnant, think you may be pregnant or if you are breast-feeding.
Slovenian: - Zdravniku takoj povejte, če nameravate zanositi, če ste ali če mislite, da bi lahko bili noseči, ali če dojite.
English: Table 6 Mean (%CV) Steady-State Pharmacokinetic Parameters of Lopinavir in HIV-Infected Pregnant Women
Slovenian: Srednji (% CV) farmakokinetični parametri v stanju ravnovesja za lopinavir pri nosečnicah, okuženih z virusom HIV
English: Mechanism of action
Slovenian: Mehanizem medsebojnega delovanja
English: Children less than 2 years of age
Slovenian: Otroci do 2. leta starosti
English: Lopinavir/ritonavir does not inhibit CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP2B6 or CYP1A2 at clinically relevant concentrations (see section 4.3).
Slovenian: Lopinavir/ritonavir v klinično pomembnih koncentracijah ne zavira CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP2B6 ali CYP1A2 (glejte poglavje 4.3).
English: Outcomes at Week 48: Study M98-863 Lopinavir/ritonavir (N=326)
Slovenian: Rezultati v 48.tednu: Študija M98-863 lopinavir/ritonavir (N=326)
English: − medicines used to treat pulmonary arterial hypertension (high blood pressure in the pulmonary artery)
Slovenian: - zdravila za zdravljenje pljučne arterijske hipertenzije (visokega krvnega tlaka v pljučni arteriji)
English: The use of a once daily dosing should be limited to those adult patients having only very few protease inhibitor (PI) associated mutations (i.e. less than 3 PI mutations in line with clinical trial results, see section 5.1 for the full description of the population) and should take into account the risk of a lesser sustainability of the virologic suppression (see section 5.1) and higher risk of diarrhoea (see section 4.8) compared to the recommended standard twice daily dosing.
Slovenian: Uporabo enkrat na dan je treba omejiti na odrasle, ki imajo le zelo malo mutacij, povezanih z zaviralci proteaz (manj kot 3 takšne mutacije v skladu z rezultati klinične študije; za celoten opis populacije glejte poglavje 5.1), in upoštevati je treba tveganje manjše stalnosti virološke supresije (glejte poglavje 5.1) in večje tveganje driske (glejte poglavje 4.8) v primerjavi s priporočeno standardno uporabo dvakrat na dan.
English: Other forms of this medicine may be more suitable for children; ask your doctor or pharmacist.
Slovenian: Za otroke so morda primernejše druge farmacevtske oblike tega zdravila; posvetujte se z zdravnikom ali framacevtom.
English: Subsequently, all patients were continued on the 300/75 mg per m2 dose.
Slovenian: Potem so vsi bolniki nadaljevali z odmerkom 300 mg/75 mg na m2.
English: Within this panel, the following mutations in HIV protease were associated with reduced in vitro susceptibility to lopinavir: L10F/I/R/V, K20M/R, L24I, M46I/L, F53L, I54L/T/V, L63P, A71I/L/T/V, V82A/F/T, I84V and L90M.
Slovenian: V tem okviru so bile z manjšo občutljivostjo za lopinavir in vitro povezane naslednje mutacije proteaze HIV: L10F/I/R/V, K20M/R, L24I, M46I/L, F53L, I54L/T/V, L63P, A71I/L/T/V, V82A/F/T, I84V in L90M.
English: Paediatric populations
Slovenian: Pediatrična populacija
English: The safety of lopinavir/ritonavir has been investigated in over 2600 patients in Phase II-IV clinical trials, of which over 700 have received a dose of 800/200 mg (6 capsules or 4 tablets) once daily.
Slovenian: Varnost lopinavirja/ritonavirja so raziskali pri več kot 2600 bolnikih v kliničnih preskušanjih faze II do IV, v katerih jih je preko 700 prejemalo odmerek 800 mg/200 mg (6 kapsul ali 4 tablete) enkrat dnevno.
English: Voriconazole: Concentrations may be decreased.
Slovenian: vorikonazol vorikonazol: koncentracija se lahko zmanjša.
English: See section 4.4 and section 4.5 for co-administration of sildenafil in patients with erectile dysfunction.
Slovenian: Glejte poglavje 4.4 in poglavje 4.5 za sočasno uporabo sildenafila pribolnikih zerektilno disfunkcijo.
English: For patients who have completed the ramp-up phase and are on a steady daily dose of venetoclax, reduce the venetoclax dose by at least 75% when used with strong CYP3A inhibitors (refer to the venetoclax SmPC for dosing instructions).
Slovenian: Za bolnike, ki so zaključili fazo povečevanja odmerka in prejemajo stalen dnevni odmerek venetoklaksa, zmanjšajte dnevni odmerek venetoklaksa za najmanj 75 %, kadar je ta uporabljen z močnimi zaviralci CYP3A (glejte povzetek glavnih značilnosti zdravila za venetoklaks).
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jiroveci pneumonia.
Slovenian: Ustrezni primeri so citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami in s Pneumocystis jiroveci povzročena pljučnica.
English: In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Slovenian: - Pri bolnikih z napredovalo okužbo z virusom HIV in z zgodovino opurtunistične infekcije se lahko znaki in simptomi vnetja prejšnje infekcije pojavijo kmalu po uvedbi zdravljenja zoper okužbo z virusom HIV.
English: Lopinavir/ritonavir does this by slowing down the spread of the infection in your body.
Slovenian: Lopinavir/ritonavir to doseže tako, da upočasni širjenje okužbe v telesu.
English: Sustained virological response to lopinavir/ritonavir (in combination with nucleoside/nucleotide reverse transcriptase inhibitors) has been also observed in a small Phase II study (M97-720) through 360 weeks of treatment.
Slovenian: Dolgotrajni virološki odziv na lopinavirj/ritonavir (v kombinaciji z nukleozidnimi/nukleotidnimi zaviralci reverzne transkriptaze) so ugotovili tudi v majhni študiji faze II (M97-720) med 360 tedni zdravljenja.
English: Co-administration with other HIV protease inhibitors (PIs) According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended.
Slovenian: Sočasna uporaba z drugimi zaviralci proteaz HIV (PI) Glede na trenutne terapevtske smernice dvotirno zdravljenje z zaviralci proteaz praviloma ni priporočljivo.
English: For infants and young children unable to swallow tablets, more suitable formulations containing lopinavir/ritonavir should be checked for their availability.
Slovenian: Za dojenčke in majhne otroke, ki ne morejo pogoltniti tablet, je treba preveriti razpoložljivost primernejše farmacevtske oblike, ki vsebuje lopinavir/ritonavir.
English: As a general rule, it is recommended that mothers infected by HIV do not breastfeed their babies under any circumstances in order to avoid transmission of HIV.
Slovenian: V splošnem se priporoča, da doječe matere, okužene z virusom HIV, nikakor ne smejo dojiti, da ne pride do prenosa virusa HIV na otroka.
English: Concomitant Therapy: Efavirenz or nevirapine
Slovenian: Sočasno zdravljenje: efavirenz ali nevirapin
English: Strong CYP3A4 inhibitors such as protease inhibitors may increase bedaquiline exposure which could potentially increase the risk of bedaquiline related adverse reactions.
Slovenian: Močni zaviralci CYP3A4 kot so zaviralci proteaz lahko povečajo izpostavljenost bedakilinu, kar bi potencialno lahko povečalo tveganje za neželene učinke povezane z bedakilinom.
English: The safety and efficacy of lopinavir/ritonavir has not been established in patients with significant underlying liver disorders.
Slovenian: Varnost in učinkovitost lopinavirja/ritonavirja nista ugotovljeni pri bolnikih s pomembnimi osnovnimi boleznimi jeter.
English: Patients with pre-existing liver dysfunction including chronic hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Slovenian: Pri bolnikih z predobstoječo disfunkcijo jeter, vključno s kroničnim hepatitisom, se med kombiniranim protiretrovirusnim zdravljenjem pogosteje pojavljajo nepravilnosti v delovanju jeter, zato jih je treba nadzirati v skladu s standardno prakso.
English: No subject experienced an increase in QTcF of ≥ 60 ms from baseline or a QTcF interval exceeding the potentially clinically relevant threshold of 500 ms.
Slovenian: Nobenemu preiskovancu se QTcF ni podaljšal za ≥ 60 ms v primerjavi z izhodiščem, dolžina intervala QTcF pa ni pri nobenem presegla potencialno klinično pomembnega praga 500 ms.
English: You should tell your doctor promptly about these or any other symptoms.
Slovenian: Zdravnika takoj obvestite o neželenih učinkih ali katerihkoli drugih simptomih.
English: Antipsychotics/ Neuroleptics
Slovenian: Antipsihotiki/ nevroleptiki lurasidon
English: Further dosage reduction of rifabutin to 150 mg twice weekly on set days is recommended for patients in whom the 150 mg dose 3 times per week is not tolerated.
Slovenian: Nadaljnje zmanjševanje odmerka rifabutina na 150 mg 2-krat na teden ob določenih dnevih je priporočljivo pribolnikih, ki ne prenašajo odmerka 150 mg 3-krat na teden.
English: − If you are currently using an oral contraceptive or using a patch contraceptive to prevent pregnancy, you should use an additional or different type of contraception (e.g. condom) as lopinavir/ritonavir may reduce the effectiveness of oral and patch contraceptives.
Slovenian: - Če za preprečevanje nosečnosti jemljete peroralne kontraceptive ali kontraceptive v obliki obliža, morate uporabiti dodatno ali drugačno kontracepcijsko zaščito (npr. kondom), kajti lopinavir/ritonavir lahko zmanjša učinkovitost peroralnih kontraceptivov ali kontraceptivov v obliki obliža.
English: This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na tableto, kar v bistvu pomeni ''brez natrija''.
English: − Lopinavir/ritonavir should always be taken every day to help control your HIV infection, no matter how much better you feel.
Slovenian: - Da bo lopinavir/ritonavir pomagal obvladovati okužbo z virusom HIV, ga morate vzeti vsak dan, ne glede na to, koliko bolje se počutite.
English: If you are taking lopinavir/ritonavir once a day
Slovenian: Če jemljete lopinavir/ritonavir enkrat na dan
English: Increased plasma concentrations of quetiapine which may lead to coma.
Slovenian: Povečana plazemska koncentracija kvetiapina, ki lahko vodi v komo.
English: − If you realise you have taken more lopinavir/ritonavir than you were supposed to, contact your doctor right away.
Slovenian: - Če ugotovite, da ste vzeli več lopinavirja/ritonavirja, kot bi bilo treba, se takoj posvetujte z zdravnikom.
English: − Muscle pain, tenderness or weakness, particularly in combination with these medicines.
Slovenian: - Bolečine, občutljivost ali šibkost mišic, zlasti v kombinaciji s protiretrovirusnimi zdravili.
English: − Lopinavir/ritonavir does not reduce the risk of passing HIV to others.
Slovenian: - Lopinavir/ritonavir ne zmanjša tveganja za prenos okužbe z virusom HIV na druge.
English: Unless otherwise stated, studies detailed below have been performed with the recommended dosage of lopinavir/ritonavir (i.e. 400/100 mg twice daily).
Slovenian: Če ni navedeno drugače, so bile spodaj omenjene študije opravljene s priporočenim odmerjanjem lopinavirja/ritonavirja (tj. 400 mg/100 mg dvakrat na dan).
English: − Do not stop or change the daily dose of lopinavir/ritonavir without first consulting with your doctor.
Slovenian: - Dnevnega odmerka lopinavirja/ritonavirja ne opuščajte in ne spreminjajte, ne da bi se prej posvetovali z zdravnikom.
English: The adequate dosing may be achieved with the two available strengths of lopinavir/ritonavir tablets: 100/25 mg and 200/50 mg.*
Slovenian: Ustrezen odmerek lahko dosežemo z uporabo dveh razpoložljivih jakosti tablet lopinavirja/ritonavirja: 100 mg/25 mg in 200 mg/50 mg.*
English: The enrolled population was moderately PI-experienced with more than half of patients having never received prior PI and around 80% of patients presenting a viral strain with less than 3 PI mutations.
Slovenian: Vključena populacija je bila zmerno izkušena z zaviralci proteaz: več kot polovica bolnikov ni še nikoli prej dobivalo zaviralce proteaz in približno 80 % bolnikov je imelo virusni sev z manj kot tremi mutacijami, povezanimi z zaviralci proteaz.
English: Based on the current data available, lopinavir/ritonavir should not be administered once daily in paediatric patients (see section 5.1).
Slovenian: Na podlagi omejenih dosedanjih podatkov, ki so na razpolago, se lopinavirja/ritonavija ne sme odmerjati enkrat na dan pri pediatričnih bolnikih (glejte poglavje 5.1).