FrancophonIA/ELRC3.0 huggingface dataset:
English: n=1, Actinomucor elegans n=1).
Croatian: Kliničko iskustvo s drugim vrstama je vrlo ograničeno (Lichtheimia spp. n=2, Cunninghamella spp. n=1, Actinomucor elegans n=1).
English: Medicinal products metabolised by CYP3A4/5
Croatian: Lijekovi koji se metaboliziraju putem CYP3A4/5
English: (CYP3A4 inhibition)
Croatian: (Inhibicija CYP3A4)
English: Prednisone (CYP3A4 substrate)
Croatian: Prednizon (supstrat za CYP3A4)
English: - sensation of tingling, tickling, or pricking of the skin (paraesthesia), - altered mental state (encephalopathy), - changes in taste (dysgeusia), - feeling of ‘spinning' or being dizzy (vertigo), - heart beat problems - may be too fast or uneven, or extra heart beats - this may show in your heart tracing (electrocardiogram or ECG), - problems with the blood circulation, - low blood pressure, - wheezing, very fast breathing, coughing up blood or blood-stained sputum, nose bleeding, - indigestion, - constipation, - feeling bloated (abdominal distension), - enlarged liver, - inflammation of the liver, - problems with the skin, red or purple spots on the skin (petechiae), inflamed skin (dermatitis),
Croatian: - nedovoljno dobivanje hranjivih tvari iz prehrane (malnutricija), - depresija, problemi sa spavanjem, - napadaji, nesvjestica ili osjećaj nesvjestice ili omaglica, - osjećaj trnaca, škakljanja ili bockanja po koži (paraestezije), - poremećaj mentalnog stanja (encefalopatija), - poremećaj okusa (disguezija), - osjećaj „vrtnje“ ili vrtoglavica, - problemi s otkucajima srca - mogu biti ubrzani, neujednačeni ili dodatni - vidljivo na snimci rada srca (elektrokardiogram iliEKG), - poremećaji cirkulacije, - niski krvni tlak, - piskanje, ubrzano disanje, iskašljavanje krvi ili ispljuvka koji sadrži krv, krvarenje iz nosa - probavne smetnje, - zatvor, - osjećaj nadutosti (nadimanje trbuha), - povećana jetra, - upala jetre, - problemi s kožom, crvena ili ljubičasta točkasta krvarenja na koži (petehije), upala kože
English: Co-administration with mild CYP3A4/5 inducers such as aprepitant, prednisone, and pioglitazone, may result in mild to moderate decreases of isavuconazole plasma levels; co-administration with mild CYP3A4/5 inducers should be avoided unless the potential benefit is considered to outweigh the risk (see section 4.5).
Croatian: Istodobna primjena sa slabim induktorima CYP3A4/5 poput aprepitanta, prednizona i pioglitazona, može rezultirati blagim do umjerenim smanjenjem razina izavukonazola u plazmi pa istodobnu primjenu sa slabim induktorima CYP3A4/5 treba izbjegavati osim ako postoji potencijalna korist za bolesnika koja bi nadmašila rizike (vidjeti dio 4.5).
English: Blood and lymphatic system disorders Uncommon Neutropenia; Thrombocytopenia^; Pancytopenia; Leukopenia^; Anaemia^ Immune system disorders Uncommon Hypersensitivity^ Metabolism and nutrition disorders Common Hypokalaemia; Decreased appetite Uncommon Hypomagnesaemia; Hypoglycaemia; Hypoalbuminaemia; Malnutrition^ Psychiatric disorders Common Delirium^ Uncommon Depression; Insomnia^ Nervous system disorders Common Headache; Somnolence Uncommon Convulsion^; Syncope; Dizziness ; Paraesthesia^; Encephalopathy; Presyncope; Neuropathy peripheral; Dysgeusia; Ear and labyrinth disorders Uncommon Vertigo Cardiac disorders Uncommon Atrial fibrillation; Tachycardia; Bradycardia^; Palpitations Atrial flutter; Electrocardiogram QT shortened; Supraventricular tachycardia; Ventricular extrasystoles ; Supraventricular extrasystoles Vascular disorders Common Thrombophlebitis^ Uncommon Circulatory collapse; Hypotension Respiratory, thoracic and mediastinal disorders Common Dyspnoea;^ Acute respiratory failure^ Uncommon Bronchospasm; Tachypnoea; Haemoptysis; Epistaxis Gastrointestinal disorders Common Vomiting; Diarrhoea; Nausea; Abdominal pain^ Uncommon Dyspepsia; Constipation; Abdominal distension Hepatobiliary disorders Common Elevated liver chemistry tests^ Uncommon Hepatomegaly; Hepatitis
Croatian: Srčani poremećaji manje često fibrilacija atrija; tahikardija; bradikardija^; palpitacije undulacija atrija; skraćenje QT intervala na elektrokardiogramu; supraventirkularna tahikardija; ventrikularne ekstrasistole; supraventrikularne ekstrasistole Krvožilni poremećaji često tromboflebitis^ manje često cirkulatorni kolaps; hipotenzija Poremećaji dišnog sustava, prsišta i sredoprsja često dispneja^; akutno zatajenje disanja^ manje često bronhospazam; tahipneja; hemoptiza; epistaksa Poremećaji probavnog sustava često povraćanje; proljev; mučnina; bol u abdomenu^ manje često dispepsija; konstipacija; abdominalna distenzija Poremećaji jetre i žuči često povišene vrijednosti laboratorijskih nalaza jetre^ manje često Hepatomegalija; hepatitis Poremećaji kože i potkožnog tkiva često osip^; pruritus manje često petehije; alopecija; izbijanje kožnih promjena uzrokovano lijekom; dermatitis^
English: Uncommon: may affect up to 1 in 100 people - reduced white blood cells - can increase your risk of infection and fever, - reduced blood cells called ‘platelets' - can increase your risk for bleeding or bruising, - reduced red blood cells - can make you feel weak or short of breath or make your skin pale, - severe reduction in blood cells - can make you feel weak, cause bruising or make infections more likely, - rash, swelling of your lips, mouth, tongue or throat with difficulty breathing (hypersensitivity), - low blood sugar levels, - low blood levels of magnesium , - low levels in the blood of a protein called ‘albumin', - not getting the right goodness from your diet (malnutrition), - depression, difficulty sleeping, - seizure, fainting or feeling faint, dizziness,
Croatian: Manje često: mogu se javiti u manje od 1 na 100 osoba - smanjenje broja bijelih krvnih stanica - može se povećati rizik od infekcije i vrućice, - smanjenje broja krvnih stanica koje se nazivaju “trombociti” - može se povećati rizik od krvarenja i nastanka modrica, - smanjenje broja crvenih krvnih stanica - može izazvati osjećaj slabosti ili nedostatak zraka te bljedoću, - jako smanjenje broja krvnih stanica - može izazvati osjećaj slabosti, modrice ili veću podložnost infekcijama, - osip, oticanje usana, usta, jezika ili grla uz otežano disanje (preosjetljivost), - niska razina šećera u krvi, - niska razina magnezija u krvi, - niska razina proteina u krvi koji se naziva “albumin”,
English: Common: may affect up to 1 in 10 people - low potassium in your blood, - decreased appetite, - hallucinations (delirium), - headache, - sleepiness, - inflamed veins that could lead to blood clots, - shortness of breath or sudden and severe difficulty breathing, - feeling sick (nausea), being sick (vomiting), diarrhoea, stomach pain, - changes in blood tests of liver function, - rash, itching, - kidney failure, - chest pain, feeling tired or sleepy, - problems where the injection was given.
Croatian: Često: mogu se javiti u manje od 1 na 10 osoba - niska vrijednost kalija u krvi, - smanjeni apetit, - halucinacije (delirij), - glavobolja, - pospanost, - upala vena zbog koje bi moglo doći do stvaranja ugrušaka, - nedostatak zraka ili naglo i jako otežano disanje, - mučnina, povraćanje, proljev, bolovi u trbuhu, - promjene krvnih nalaza funkcije jetre, - osip, svrbež, - zatajenje bubrega, - bolovi u prsima, osjećaj umora ili pospanosti, - problemi na mjestu primanja injekcije.
English: Common: may affect up to 1 in 10 people - low potassium in your blood, - decreased appetite, - hallucinations (delirium), - headache, - sleepiness, - inflamed veins that could lead to blood clots, - shortness of breath or sudden and severe difficulty breathing, - feeling sick (nausea), being sick (vomiting), diarrhoea, stomach pain, - changes in blood tests of liver function, - rash, itching, - kidney failure, - chest pain, feeling tired or sleepy.
Croatian: Često: mogu se javiti u više od 1 na 10 osoba - niska vrijednost kalija u krvi, - smanjeni apetit, - halucinacije (delirij), - glavobolja, - pospanost, - upala vena zbog koje bi moglo doći do stvaranja ugrušaka, - nedostatak zraka ili naglo i jako otežano disanje, - mučnina, povraćanje, proljev, bolovi u trbuhu, - promjene krvnih nalaza funkcije jetre,, - osip, svrbež, - zatajenje bubrega, - bolovi u prsima, osjećaj umora ili pospanosti.
English: How to use Cresemba
Croatian: Kako primjenjivati lijek Cresemba
English: Do not take Cresemba: - if you are allergic to isavuconazole or any of the other ingredients of this medicine (listed in section 6), - if you have a heart beat problem called ‘familial short QT syndrome', - if you are using any of the following medicines: - ketoconazole, used for fungal infections, - high doses of ritonavir (400 mg every 12 hours), used for HIV, - rifampicin, rifabutin, used for tuberculosis, - carbamazepine, used for epilepsy, - barbiturate medicines like phenobarbital, used for epilepsy and sleep disorders,
Croatian: Nemojte primjenjivati lijek Cresemba: - ako ste alergični na izavukonazol ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.), - ako imate problema s otkucajima srca poznatim kao „nasljedni sindrom kratkog QT intervala“, - ako uzimate bilo koji od sljedećih lijekova: - ketokonazol, za liječenje gljivičnih infekcija, - visoke doze ritonavira (400 mg svakih 12 sati), za liječenje HIV-a, - rifampicin, rifabutin za liječenje tuberkuloze, - karbamazepin za liječenje epilepsije, - barbiturate poput fenobarbitala za liječenje epilepsije i poremećaja spavanja, - fenitoin za liječenje epilepsije, - gospinu travu, biljni lijek za depresiju, - efavirenz, etravirin za liječenje HIV-a, - nafcilin za liječenje bakterijskih infekcija.
English: If you stop taking Cresemba
Croatian: Ako prekinete s uzimanjem lijeka Cresemba
English: How to store Cresemba
Croatian: Kako čuvati lijek Cresemba
English: Do not use Cresemba: - if you are allergic to isavuconazole or any of the other ingredients of this medicine (listed in section 6), - if you have a heart beat problem called ‘familial short QT syndrome', - if you are using any of the following medicines: - ketoconazole, used for fungal infections, - high doses of ritonavir (400 mg every 12 hours), used for HIV, - rifampicin, rifabutin, used for tuberculosis, - carbamazepine, used for epilepsy, - barbiturate medicines like phenobarbital, used for epilepsy and sleep disorders, - phenytoin, used for epilepsy, - St John's wort, a herbal medicine used for depression,
Croatian: Lijek Cresemba nemojte uzimati : - ako ste alergični na izavukonazol ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.), - ako imate problema s otkucajima srca poznatim kao „nasljedni sindrom kratkog QT intervala“, - ako uzimate bilo koji od sljedećih lijekova: - ketokonazol, za liječenje gljivičnih infekcija, - visoke doze ritonavira (400 mg svakih 12 sati), za liječenje HIV-a, - rifampicin, rifabutin za liječenje tuberkuloze, - karbamazepin za liječenje epilepsije, - barbiturate poput fenobarbitala za liječenje epilepsije i poremećaja spavanja, - fenitoin za liječenje epilepsije, - gospinu travu, biljni lijek za depresiju, - efavirenz, etravirin za liječenje HIV-a, - nafcilin za liječenje bakterijskih infekcija.
English: (CYP3A4/5 inhibition).
Croatian: (Inhibicija CYP3A4/5).
English: No CRESEMBA dose adjustment necessary.
Croatian: Nije potrebno prilagodba doze lijeka CRESEMBA.
English: Adverse Drug Reactions Blood and lymphatic system disorders Uncommon Neutropenia; Thrombocytopenia^; Pancytopenia; Leukopenia^; Anaemia^ Immune system disorders Uncommon Hypersensitivity^ Metabolism and nutrition disorders Common Hypokalaemia; Decreased appetite Uncommon Hypomagnesaemia; Hypoglycaemia; Hypoalbuminaemia; Malnutrition^ Psychiatric disorders Common Delirium^ Uncommon Depression; Insomnia^ Nervous system disorders Common Headache; Somnolence Uncommon Convulsion^; Syncope; Dizziness ; Paraesthesia^; Encephalopathy; Presyncope; Neuropathy peripheral; Dysgeusia; Ear and labyrinth disorders Uncommon Vertigo Cardiac disorders Uncommon Atrial fibrillation; Tachycardia; Bradycardia^; Palpitations Atrial flutter; Electrocardiogram QT shortened; Supraventricular tachycardia; Ventricular extrasystoles ; Supraventricular extrasystoles
Croatian: Poremećaji metabolizma i prehrane često hipokalemija; smanjen apetit manje često hipomagnezemija; hipoglikemija; hipoalbuminemija; malnutricija^ Psihijatrijski poremećaji često delirij^ manje često depresija; nesanica^ Poremećaji živčanog sustava često glavobolja; somnolencija manje često konvulzije^; sinkopa; omaglica; parestezije^; encefalopatija; presinkopa; periferna neuropatija; disgeuzija; Poremećaji uha i labirinta manje često vrtoglavica
English: Antidiabetics
Croatian: Antidijabetici
English: Dabigatran etexilate concentrations may increase.
Croatian: Koncentracije dabigatraneteksilata se mogu povećati.
English: Methotrexate: no dose adjustment required.
Croatian: Metotreksat: nije potrebna prilagodba doze.
English: The concomitant administration of CRESEMBA and nafcillin is contraindicated.
Croatian: Istodobna primjena lijeka CRESEMBA i nafcilina je kontraindicirana.
English: Omeprazole: no dose adjustment required.
Croatian: Omeprazol: nije potrebna prilagodba doze.
English: Dextromethorphan:
Croatian: Dekstrometorfan:
English: Isavuconazole concentrations may significantly decrease.
Croatian: Koncentracije izavukonazola mogu se značajno smanjiti.
English: Methotrexate: AUCinf: ↓ 3% Cmax: ↓ 11%
Croatian: AUCinf: ↓ 3% Cmax: ↓ 11%
English: Etravirine (moderate CYP3A4/5 inducer)
Croatian: Etravirin (umjereni induktor enzima CYP3A4/5)
English: (CYP3A4/5 induction)
Croatian: (Indukcija CYP3A4/5)
English: Pioglitazone (mild CYP3A4/5 inducer)
Croatian: Pioglitazon (slab induktor enzima CYP3A4/5)
English: Hepatic impairment
Croatian: Udarna doza
English: QT shortening
Croatian: Skraćenje QT intervala
English: Esomeprazole: no dose adjustment required.
Croatian: Ezomeprazol: nije potrebna prilagodba doze.
English: Carton for 100 mg hard capsules
Croatian: Kutija za tvrde kapsule od 100 mg
English: You may have more side effects such as: - headache, feeling dizzy, restless or sleepy, - tingling, reduced sense of touch or sensation in the mouth, - problems being aware of things, hot flushes, anxiety, joint pain, - changes in the way things taste, dry mouth, diarrhoea, vomiting,
Croatian: Možete imati više nuspojava kao što su: - glavobolja, omaglica, nemir ili pospanost, - trnci, smanjenje osjeta dodira ili osjeta u ustima,
English: (CYP3A4/5 inhibition)
Croatian: (Inhibicija CYP3A4/5)
English: Antigout agent Colchicine (P-gp substrate)
Croatian: Lijekovi protiv gihta Kolhicin (Supstrat za P-gp)
English: Oral contraceptives Ethinyl oestradiol and norethindrone
Croatian: Oralni kontraceptivi Etinilestradiol i noretindron (supstrati za CYP3A4/5)
English: Label on vial for 200 mg powder for concentrate for solution for infusion
Croatian: Naljepnica na bočici za 200 mg praška za koncentrat za otopinu za infuziju
English: The concomitant administration of CRESEMBA and efavirenz is contraindicated.
Croatian: Istodobna primjena lijeka CRESEMBA i efavirenza je kontraindicirana.
English: Range
Croatian: Raspon
English: Carton for vial for 200 mg powder for concentrate for solution for infusion
Croatian: Kutija za bočicu za 200 mg praška za koncentrat za otopinu za infuziju
English: (mild CYP3A4/5 inducer)
Croatian: (slab induktor CYP3A4/5)
English: Indinavir (CYP3A4/5 strong inhibitor and substrate)
Croatian: Indinavir (snažan inhibitor i supstrat za CYP3A4/5)
English: Antifungals
Croatian: Antitusici
English: Each vial contains 372.6 mg isavuconazonium sulfate,
Croatian: Jedna bočica sadrži 372,6 mg izavukonazonijevog sulfata što odgovara 200 mg izavukonazola.
English: Herbal medicines St John's wort (strong CYP3A4/5 inducer)
Croatian: Antibkterijski lijekovi Rifampicin (snažan induktor CYP3A4/5)
English: Tel: +39 06 33 18 21
Croatian: Pfizer Italia S.r.l. Tel: +39 06 33 18 21
English: Skin and subcutaneous tissue disorders Common Rash^; Pruritus Uncommon Petechiae; Alopecia; Drug eruption; Dermatitis^ Musculoskeletal and connective tissue disorders Uncommon Back pain
Croatian: Nuspojave na lijek Poremećaji krvi i limfnog sustava manje često neutropenija; trombocitopenija^; pancitopenija; leukopenija^; anemija^
English: Discard partially-used vials.
Croatian: Djelomično iskorištene bočice bacite.
English: Warfarin: no dose adjustment required.
Croatian: Varfarin: nije potrebna prilagodba doze.
English: For example:
Croatian: Primjerice:
English: Do not exceed the recommended dose or duration of treatment.
Croatian: Nemojte prekoračiti preporučenu dozu ili trajanje liječenja.
English: The product information may be subsequently updated by the Member State competent authorities, in liaison with the Reference Member State, as appropriate, in accordance with the procedures laid down in Chapter 4 of Title III of Directive 2001/83/EC.
Croatian: Nadležna tijela država članica mogu naknadno ažurirati informacije o lijeku, na odgovarajući način u suradnji s referentnom državom članicom, sukladno postupcima navedenima u poglavlju 4 glave III Direktive 2001/83/EC.
English: The dosage should be adjusted to the severity of the disorder and the complaints of the patient.
Croatian: Doziranje se mora prilagoditi jačini poremećaja i pritužbama bolesnika.
English: Severe heart failure (NYHA Class IV)
Croatian: Teško zatajenje srca (NYHA stupanj IV)
English: Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms (see section 4.4).
Croatian: Nuspojave se mogu minimizirati primjenom najniže učinkovite doze tijekom najkraćeg vremena potrebnog za kontrolu simptoma (vidjeti dio 4.4)
English: [Invented name] may affect or be affected by some other medicines.
Croatian: [Zaštićeno ime] može utjecati na druge lijekove ili na njega mogu utjecati drugi lijekovi.
English: You should discuss your treatment with your doctor or pharmacist before taking [Invented name] if you:
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete [zaštićeno ime] ako:
English: For all ibuprofen-containing products
Croatian: Za sve lijekove koji sadrže ibuprofen
English: - medicines that reduce high blood pressure (ACE-inhibitors such as captopril, beta-blockers such as atenolol medicines, angiotensin-II receptor antagonists such as losartan)
Croatian: - lijekovi koji snižavaju visoki krvni tlak (ACE-inhibitori poput kaptoprila, beta-blokatori poput atenolola, antagonisti receptora angiotenzina-II kao što je losartan)
English: You should therefore always seek the advice of your doctor or pharmacist before you use [Invented name] with other medicines.
Croatian: Uvijek provjerite s Vašim liječnikom ili ljekarnikom prije upotrebe lijeka[zaštićeno ime] zajedno s drugim lijekovima.
English: - have high blood pressure, diabetes, high cholesterol, have a family history of heart disease or stroke, or if you are a smoker.
Croatian: - imate visoki krvni tlak, dijabetes, visoki kolesterol, povijest srčane bolesti ili moždanog udara u obitelji, ili ako ste pušač.
English: B. Package Leaflet Section 2 - What you need to know before you take [Invented name]
Croatian: Uputa o lijeku Dio 2 - Što morate znati prije nego počnete uzimati lijek [zaštićeno ime]
English: Other medicines and [Invented name] [The section should be amended to reflect the following wording]
Croatian: Drugi lijekovi i [zaštićeno ime] [Ovaj dio treba izmijeniti tako da sadrži sljedeći tekst]
English: Although there are limited data on the arterial thrombotic risk of dexibuprofen, it is reasonable to assume that the risk with high dose dexibuprofen (1200 mg/day) would be similar to that associated with high dose ibuprofen (2400 mg/day).
Croatian: Iako su podaci o riziku od arterijskih trombotičnih događaja kod primjene deksibuprofena ograničeni, razumna je pretpostavka da će rizik visoke doze deksibuprofena (1200 mg/dan) biti sličan riziku povezanom s visokim dozama ibuprofena (2400 mg/dan).
English: - have heart problems including heart failure, angina (chest pain), or if you have had a heart attack, bypass surgery, peripheral artery disease (poor circulation in the legs of feet due to narrow or blocked arteries), or any kind of stroke (including ‘mini-stroke' or transient ischaemic attack “TIA”).
Croatian: - imate srčanih problema, uključujući zatajenje srca, anginu (bol u prsištu), ili ako ste imali srčani udar, ugradnju premosnice, bolest perifernih arterija (slabu cirkulaciju u stopalima zbog uskih ili začepljenih arterija) ili bilo koju vrstu moždanog udara (uključujući "mini moždani udar" ili prolazni ishemijski napadaj).
English: These amendments to the relevant sections of the Summary of Product Characteristics and Package Leaflet are the outcome of the referral procedure.
Croatian: Ove izmjene određenih dijelova sažetka opisa svojstava lijeka i upute o lijeku ishod su arbitražnog postupka.
English: Concomitant administration of dexibuprofen and acetylsalicylic acid is not generally recommended because of the potential of increased adverse effects.
Croatian: Istodobna primjena deksibuprofena i acetilsalicilatne kiseline općenito se ne preporučuje zbog veće mogućnosti nuspojava.
English: Overall, epidemiological studies do not suggest that low dose ibuprofen (e.g. ≤ 1200 mg/day) is associated with an increased risk of arterial thrombotic events.
Croatian: Općenito, epidemiološka ispitivanja ne upućuju na to da bi ibuprofen u niskoj dozi (npr. ≤ 1200 mg/dan) bio povezan s povećanim rizikom od arterijskih trombotičnih događaja.
English: - medicines that are anti-coagulants (i.e. thin blood/prevent clotting e.g. aspirin/acetylsalicylic acid, warfarin, ticlopidine)
Croatian: - lijekovi koji su antikoagulansi (tj. razrjeđuju krv/sprječavaju zgrušavanje krvi, primjerice, aspirin/acetilsalicilatna kiselina, vafarin, tiklopidin)
English: Some pharmacodynamic studies show that when single doses of ibuprofen 400 mg were taken within 8 h before or within 30 min after immediate release acetylsalicylic acid dosing (81 mg), a decreased effect of acetylsalicylic acid on the formation of thromboxane or platelet aggregation occurred.
Croatian: Određena ispitivanja farmakodinamike pokazuju da je zamijećen smanjen učinak acetilsalicilatne kiseline na stvaranje tromboksana ili agregaciju trombocita kada se jednokratna doza ibuprofena od 400 mg uzela unutar 8 sati prije, ili unutar 30 minuta nakon uzimanja acetilsalicilatne kiseline s trenutnim oslobađanjem (81 mg).
English: Annex III Amendments to relevant sections of the summary of product characteristics and package leaflet
Croatian: Dodatak III Izmjene određenih dijelova sažetka opisa svojstava lijeka i upute o lijeku
English: Experimental data suggest that ibuprofen may competitively inhibit the effect of low dose acetylsalicylic acid on platelet aggregation when they are dosed concomitantly.
Croatian: Eksperimentalni podaci pokazuju da ibuprofen može kompetitivno inhibirati učinak niske doze acetilsalicilatne kiseline na agregaciju trombocita, ako se oba lijeka uzimaju istodobno.
English: Concomitant administration of ibuprofen and acetylsalicylic acid is not generally recommended because of the potential of increased adverse effects.
Croatian: Istodobna primjena ibuprofena i acetilsalicilatne kiseline općenito se ne preporučuje zbog veće mogućnosti nuspojava.
English: No clinically relevant effect is considered to be likely for occasional ibuprofen use (see section 5.1).
Croatian: Smatra se da pri povremenom uzimanju ibuprofena klinički značajan učinak nije vjerojatan (vidjeti dio 5.1).
English: Although there are uncertainties regarding extrapolation of these data to the clinical situation, the possibility that regular, long-term use of ibuprofen may reduce the cardioprotective effect of low-dose acetylsalicylic acid cannot be excluded.
Croatian: Iako postoje nesigurnosti glede ekstrapolacije ovih podataka na kliničku praksu, mogućnost da redovita, dugotrajna primjena ibuprofena može smanjiti kardioprotektivni učinak niske doze acetilsalicilatne kiseline ne može se isključiti.