FrancophonIA/ELRC3.0 huggingface dataset:
English: Treatment was well tolerated as documented by clinical laboratory tests, vital signs, and ECG interval data, including QTc.
Slovenian: Bolniki so zdravilo dobro prenašali, kar so pokazali tudi klinični laboratorijski testi, vitalni znaki in podatki o EKG intervalih, vključno z QTc.
English: The effect of desloratadine on newborns/infants is unknown.
Slovenian: Učinek desloratadina na dojene novorojence/otroke ni znan.
English: These symptoms include itching and hives.
Slovenian: Ti simptomi vključujejo srbenje in koprivnico.
English: Swallow the tablet whole with water.
Slovenian: Tableto pogoltnite celo z vodo.
English: Common in children less than 2 years of age: the following may affect up to 1 in 10 children
Slovenian: Pogosti, pri otrocih, mlajših od 2 let: naslednji se lahko pojavijo pri največ 1 od 10 otrocih
English: The absence of upper respiratory tract infection or structural abnormalities, as well as patient history, physical examinations, and appropriate laboratory and skin tests should be considered.
Slovenian: Upoštevajte morebitne okužbe zgornjih dihal ali strukturne anomalije, pa tudi bolnikovo anamnezo, fizikalne preglede in ustrezne laboratorijske in kožne preiskave.
English: For urticaria, the duration of treatment may be variable from patient to patient and therefore you should follow the instructions of your physician.
Slovenian: Pri urtikariji se lahko potrebna dolžina zdravljenja razlikuje od bolnika do bolnika, zato upoštevajte navodila zdravnika.
English: Desloratadine is a non-sedating, long-acting histamine antagonist with selective peripheral H1receptor antagonist activity.
Slovenian: Desloratadin je nesedativen, dolgodelujoč histaminski antagonist s selektivnim antagonističnim delovanjem na periferne histaminske receptorje H1.
English: The enzyme responsible for the metabolism of desloratadine has not been identified yet, and therefore, some interactions with other medicinal products cannot be fully excluded.
Slovenian: Encima, ki je odgovoren za presnovo desloratadina, še niso določili, zato ni mogoče v celoti izključiti nekaterih interakcij desloratadina z drugimi zdravili.
English: In the case of severe renal insufficiency, Aerius should be used with caution (see section 5.2).
Slovenian: V primeru hude ledvične insuficience morate zdravilo Aerius uporabljati previdno (glejte poglavje 5.2).
English: Detailed information on this medicine is available on the European Medicines Agency website http://www.ema.europa.eu.
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http:// www.ema.europa.eu.
English: Other undesirable effects reported during the post-marketing period in paediatric patients with an unknown frequency included QT prolongation, arrhythmia, bradycardia, abnormal behaviour, and aggression.
Slovenian: Ostali neželeni učinki, o katerih so poročali v obdobju trženja zdravila pri pediatričnih bolnikih z neznano pogostnostjo, vključujejo podaljšanje QT intervala, aritmijo, bradikardijo, nenormalno vedenje in agresivnost.
English: Contains propylene glycol and sorbitol.
Slovenian: Vsebuje propilenglikol in sorbitol.
English: Nevertheless, as there is individual variation in response to all medicinal products, it is recommended that patients are advised not to engage in activities requiring mental alertness, such as driving a car or using machines, until they have established their own response to the medicinal product.
Slovenian: Ker pa se pri vseh zdravilih odziv posameznikov razlikuje, je priporočljivo bolnikom svetovati, da ne opravljajo dejavnosti, ki zahtevajo pozornost, kot je vožnja avtomobila ali upravljanje s stroji, dokler ne ugotovijo, kako se odzovejo na zdravilo.
English: The adverse event profile associated with overdosage, as seen during post-marketing use, is similar to that seen with therapeutic doses, but the magnitude of the effects can be higher.
Slovenian: Profil neželenih učinkov pri prevelikem odmerjanju, opaženem v obdobju trženja zdravila, je podoben kot pri terapevtskih odmerkih, le da je jakost učinkov lahko večja.
English: Non-clinical studies conducted with desloratadine and loratadine demonstrated that there are no qualitative or quantitative differences in the toxicity profile of desloratadine and loratadine at comparable levels of exposure to desloratadine.
Slovenian: Predklinične raziskave z desloratadinom in loratadinom so pokazale, da ni kakovostnih ali količinskih razlik med profiloma toksičnosti desloratadina in loratadina pri primerljivi ravni izpostavljenosti desloratadinu.
English: In both studies, changes in exposure (AUC and Cmax) of desloratadine and 3-hydroxydesloratadine were not clinically relevant.
Slovenian: Spremembe izpostavljenosti (AUC in Cmax) desloratadinu in 3-hidroksidesloratadinu v nobeni od obeh študij niso bile klinično pomembne.
English: In two placebo-controlled six week trials in patients with chronic idiopathic urticaria, Aerius was effective in relieving pruritus and decreasing the size and number of hives by the end of the first dosing interval.
Slovenian: V dveh s placebom kontroliranih šesttedenskih preskušanjih pri bolnikih s kronično idiopatsko urtikarijo je zdravilo Aerius učinkovito blažilo srbenje in zmanjšalo velikost in število izpuščajev koprivnice že do konca prvega intervala odmerjanja.
English: Water had no effect on the bioavailability of Aerius orodispersible tablets.
Slovenian: Voda ni vplivala na biološko uporabnost zdravila Aerius orodisperzibilne tablete.
English: However, cases of alcohol intolerance and intoxication have been reported during post-marketing use.
Slovenian: Kljub temu so v obdobju trženja zdravila poročali o primerih intolerance in zastrupitve z alkoholom.
English: Although most people do not experience drowsiness, it is recommended not to engage in activities requiring mental alertness, such as driving a car or operating machinery until you have established your own response to the medicinal product.
Slovenian: Čeprav se pri večini ljudi zaspanost ne pojavi, je priporočljivo, da ne opravljate dejavnosti, ki zahtevajo pozornost, kot je vožnja avtomobila ali upravljanje strojev, dokler ne ugotovite vašega odziva na zdravilo.
English: Water or other liquid is not needed to swallow the dose.
Slovenian: Bolnik ne bo potreboval vode ali druge tekočine, da pogoltne odmerek.
English: Desloratadine does not inhibit CYP3A4 in vivo, and in vitro studies have shown that the medicinal product does not inhibit CYP2D6 and is neither a substrate nor an inhibitor of P-glycoprotein.
Slovenian: Desloratadin ne inhibira encima CYP3A4 in vivo, in vitro študije pa so pokazale, da zdravilo tudi ne inhibira encima CYP2D6 in da ni ne substrat ne inhibitor P-glikoproteina.
English: Excipient(s) with known effect: This medicinal product contains 150 mg/ml of sorbitol
Slovenian: Pomožne snovi z znanim učinkom: To zdravilo vsebuje 150 mg/ml sorbitola.
English: INFORMATION IN BRAILLE
Slovenian: PODATKI O BRAILLOVI PISAVI
English: The prescriber should be aware that most cases of rhinitis below 2 years of age are of infectious origin (see section 4.4) and there are no data supporting the treatment of infectious rhinitis with Aerius.
Slovenian: Zdravnik, ki predpiše zdravilo, naj se zaveda, da je pri otrocih, mlajših od 2 let, večina primerov rinitisa infekcijskega izvora (glejte poglavje 4.4) in da ni nobenih podatkov, ki bi govorili v prid zdravljenju infekcijskega rinitisa z zdravilom Aerius.
English: In clinical trials in a paediatric population, the desloratadine syrup formulation was administered to a total of 246 children aged 6 months through 11 years.
Slovenian: V kliničnih preskušanjih pri pediatričnih populacijah so zdravilo desloratadin sirup dajali skupaj 246 otrokom, starim od 6 mesecev do 11 let.
English: The greatest amelioration was seen in the domains of practical problems and daily activities limited by symptoms.
Slovenian: Največje izboljšanje so ugotavljali v zvezi s praktičnimi problemi in pri dnevnih dejavnostih, ki jih sicer ovirajo simptomi te bolezni.
English: The lack of carcinogenic potential was demonstrated in studies conducted with desloratadine and loratadine.
Slovenian: Odsotnost kancerogenih učinkov so pokazali v študijah z desloratadinom in loratadinom.
English: Therefore, caution is recommended if alcohol is taken concomitantly.
Slovenian: Pri sočasnem uživanju alkohola je zato potrebna previdnost.
English: The safety of desloratadine in children 2- to 11-years of age who are poor metabolisers is the same as in children who are normal metabolisers.
Slovenian: Varnost zdravila desloratadin pri otrocih, starih od 2 do 11 let, ki slabo presnavljajo zdravilo, je enaka kot pri tistih otrocih, ki zdravilo presnavljajo normalno.
English: Hypersensitivity to the active substance, to any of the excipients listed in section 6.1, or to loratadine.
Slovenian: Preobčutljivost na zdravilno učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1, ali na loratadin.
English: Children, 1-11 years of age, who were candidates for antihistamine therapy received a daily desloratadine dose of 1.25 mg (1 through 5 years of age) or 2.5 mg (6 through 11 years of age).
Slovenian: Otroci v starosti od 1 do 11 let, ki so bili kandidati za antihistaminsko terapijo, so prejemali dnevni odmerek desloratadina po 1,25 mg (starost od 1 do 5 let) ali 2,5 mg (starost od 6 do 11 let).
English: Aerius 2.5 mg tablets has not been evaluated in paediatric patients however in conjunction with the dose finding studies in paediatrics, the pharmacokinetics data for Aerius orodispersible tablets supports the use of the 2.5 mg dose in paediatric patients 6 to 11 years of age.
Slovenian: Uporabe zdravila Aerius 2,5 mg tablete niso ovrednotili pri pediatričnih bolnikih, vendar pa skupaj s študijami za ugotavljanje pediatričnega odmerka tudi farmakokinetični podatki za zdravilo Aerius orodisperzibilne tablete govorijo v prid uporabi 2,5 mg odmerka pri pediatričnih bolnikih starih 6 do 11 let.
English: In each trial, the effects were sustained over the 24 hour dosing interval.
Slovenian: V vsakem preskušanju so učinki zdravila trajali ves čas 24-urnega intervala odmerjanja.
English: The exposure (AUC) to desloratadine was about 6-fold higher and the Cmax was about 3 to 4 fold higher at 3-6 hours with a terminal half-life of approximately 120 hours.
Slovenian: Izpostavljenost (AUC) desloratadinu je bila približno 6-krat večja, vrednost Cmax pa je bila približno 3 do 4-krat večja po 3 do 6 urah, pri čemer je bila razpolovna doba končne faze približno 120 ur.
English: However, the safety of desloratadine syrup formulation, which contains the same concentration of desloratadine as Aerius oral solution, was demonstrated in three paediatric trials.
Slovenian: Varnost desloratadina v obliki sirupa, ki vsebuje isto koncentracijo desloratadina kot Aerius peroralna raztopina, pa so dokazali v treh preskušanjih pri pediatričnih bolnikih.
English: You can take this medicine with or without food.
Slovenian: To zdravilo lahko jemljete s hrano ali brez.
English: Aspartame is a source of phenylalanine, which may be harmful for people with phenylketonuria.
Slovenian: Aspartam je vir fenilalanina, ki je lahko škodljiv za osebe s fenilketonurijo.
English: ● hallucinations
Slovenian: ● halucinacije
English: What Aerius is Aerius contains desloratadine which is an antihistamine.
Slovenian: Kaj je zdravilo Aerius Zdravilo Aerius vsebuje desloratadin, ki je antihistaminik.
English: These include inhibiting the release of proinflammatory cytokines such as IL-4, IL-6, IL-8, and IL-13 from human mast cells/basophils, as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells.
Slovenian: Med drugim gre pri tem za inhibicijo sproščanja vnetnih citokinov, kakor so npr. IL-4, IL-6, IL-8 in IL-13 iz človeških mastocitov ali bazofilcev, pa tudi za inhibicijo ekspresije adhezijske molekule P-selektina na endotelijskih celicah.
English: ● increased sensitivity of the skin to the sun, even in case of hazy sun, and to UV light, for instance to UV lights of a solarium
Slovenian: ● povečana občutljivost kože za sonce, tudi če gre za indirektno izpostavljenost soncu (čez oblake, meglo) in UV (ultravijolično) svetlobo, na primer UV svetlobo v solariju.
English: The frequency of the clinical trial adverse reactions reported in excess of placebo and other undesirable effects reported during the post-marketing period are listed in the following table.
Slovenian: Neželeni učinki, o katerih so med kliničnim preskušanjem poročali pogosteje kot pri placebu in ostali neželeni učinki, o katerih so poročali v obdobju trženja zdravila, so našteti v naslednji preglednici.
English: Desloratadine is not eliminated by haemodialysis; it is not known if it is eliminated by peritoneal dialysis.
Slovenian: Desloratadina iz telesa ni mogoče odstraniti s hemodializo in ni znano, ali se odstranjuje s peritonealno dializo.
English: Phenylalanine may be harmful for people with phenylketonuria.
Slovenian: Fenilalanin je lahko škodljiv za osebe s fenilketonurijo.
English: Excipient(s) with known effect: This medicine contains lactose.
Slovenian: Pomožne snovi z znanim učinkom: To zdravilo vsebuje laktozo.
English: In adolescents, headache was the most commonly reported side effect.
Slovenian: Pri mladostnikih je bil najpogosteje prijavljen neželeni učinek glavobol.
English: ● aggression
Slovenian: ● agresivnost
English: Aerius orodispersible tablet contains aspartame This product contains aspartame.
Slovenian: Zdravilo Aerius orodisperzibilna tableta vsebuje aspartam To zdravilo vsebuje aspartam.
English: The most frequent of adverse events reported in excess of placebo were fatigue (1.2 %), dry mouth (0.8 %) and headache (0.6 %).
Slovenian: Najpogostejši neželeni učinki, katerih pogostnost je bila večja kot pri placebu, so bili utrujenost (1,2 %), suha usta (0,8 %) in glavobol (0,6 %).
English: Approximately 6 % of adults and children 2- to 11-year old are phenotypic poor metabolisers of desloratadine and exhibit a higher exposure (see section 5.2).
Slovenian: Približno 6 % odraslih in otrok, starih od 2 do 11 let, ima fenotip slabega presnavljanja desloratadina in je pri njih izpostavljenost zdravilu večja (glejte poglavje 5.2).
English: The dose of orodispersible tablet is placed in the mouth where it will disperse immediately.
Slovenian: Orodisperzibilno tableto naj položi v usta, kjer bo takoj razpadel.
English: Do not take a double dose to make up for forgotten individual doses.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji individualni odmerek.
English: In infants and toddlers aged 6 to 23 months, the most frequent adverse reactions reported in excess of placebo were diarrhoea (3.7 %), fever (2.3 %) and insomnia (2.3 %).
Slovenian: Pri dojenčkih in majhnih otrocih, starih od 6 do 23 mesecev, so bili najpogostejši neželeni učinki, o katerih so poročali z večjo pogostnostjo kot pri placebu, driska (3,7 %), zvišana telesna temperatura (2,3 %) in nespečnost (2,3 %).
English: In a series of pharmacokinetic and clinical trials, 6 % of the subjects reached a higher concentration of desloratadine.
Slovenian: V vrsti farmakokinetičnih in kliničnih preskušanj je 6 % preiskovancev doseglo večje koncentracije desloratadina.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno motnjo neprenašanja galaktoze, laponske oblike pomanjkanja laktaze ali malabsorpcije glukoze in galaktoze ne smejo jemati tega zdravila.
English: The overall incidence of adverse reactions was similar between the desloratadine syrup and the placebo groups and did not differ significantly than the safety profile seen in adult patients.
Slovenian: Skupna incidenca neželenih učinkov pri sirupu z desloratadinom je bila podobna kot v skupini, ki je prejemala placebo, in se ni bistveno razlikovala od profila varnosti tega zdravila pri odraslih bolnikih.
English: Since histamine release is a causal factor in all urticarial diseases, desloratadine is expected to be effective in providing symptomatic relief for other urticarial conditions, in addition to chronic idiopathic urticaria, as advised in clinical guidelines.
Slovenian: Ker pa je vzročni dejavnik pri vseh urtikarijskih boleznih enak, to je sproščanje histamina, lahko upravičeno pričakujemo, da bi z uporabo desloratadina dosegli učinkovito lajšanje simptomov tudi pri drugih urtikarijskih stanjih poleg kronične idiopatske urtikarije, saj je to priporočeno tudi v kliničnih smernicah.
English: ● restlessness with increased
Slovenian: ● nemir z okrepljenimi
English: ● fatigue
Slovenian: • utrujenost
English: During the marketing of Aerius, cases of severe allergic reactions (difficulty in breathing, wheezing, itching, hives and swelling) have been reported very rarely.
Slovenian: Med trženjem zdravila Aerius so zelo redko poročali o primerih hudih alergijskih reakcij (težave z dihanjem, piskanje, srbenje, koprivnica in otekanje).
English: An improvement in pruritus of more than 50 % was observed in 55 % of patients treated with desloratadine compared with 19 % of patients treated with placebo.
Slovenian: Pri 55 % bolnikov, zdravljenih z desloratadinom, so ugotavljali več kot 50 % izboljšanje srbenja, v primerjavi z 19 % bolnikov, zdravljenih s placebom.
English: If you forget to take your dose on time, take it as soon as possible and then go back to your regular dosing schedule.
Slovenian: Če ste pozabili vzeti odmerek pravočasno, ga vzemite čimprej in potem nadaljujte z ustaljenim režimom odmerjanja.
English: The overall safety profile of these subjects was not different from that of the general population.
Slovenian: Skupni profil varnosti pri teh preiskovancih se ni razlikoval od profila za splošno populacijo.
English: In an additional study, no adverse events were seen in subjects between 6 and 11 years of age following a single 2.5 mg dose of desloratadine oral solution.
Slovenian: V dodatni študiji niso opazili nobenih neželenih učinkov pri preiskovancih, starih od 6 do 11 let, po dajanju enkratnega 2,5 mg odmerka desloratadina v peroralni raztopini.
English: In a separate study, grapefruit juice had no effect on the disposition of desloratadine.
Slovenian: V ločeni študiji sok grenivke ni imel nobenega vpliva na porazdelitev desloratadina.
English: - if you have medical or familial history of seizures.
Slovenian: - če ste imeli v preteklosti vi ali kdo v vaši družini epileptične napade.
English: In separate single dose studies, at the recommended doses, paediatric patients had comparable AUC and Cmax values of desloratadine to those in adults who received a 5 mg dose of desloratadine syrup.
Slovenian: V ločenih študijah uporabe enkratnega odmerka desloratadina v priporočenih odmerkih so bile vrednosti AUC in Cmax pri pediatričnih bolnikih podobne tistim pri odraslih, ki so prejeli 5 mg odmerek sirupa z desloratadinom.
English: At the recommended dose, this medicine is not expected to affect your ability to drive or use machines.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Ni pričakovati, da bi to zdravilo v priporočenem odmerku vplivalo na vašo sposobnost za vožnjo ali upravljanje strojev.
English: This medicinal product contains sorbitol; thus, patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Slovenian: To zdravilo vsebuje sorbitol, zato ga ne smejo jemati bolniki z redkimi dednimi boleznimi, ki imajo prirojeno intoleranco fruktoze, pri glukoza-galaktoza malabsorpcijskem sindromu ali pomanjkanju saharozne-izomaltaze.
English: Desloratadine plasma concentrations can be detected within 30 minutes of administration.
Slovenian: Plazemsko koncentracijo desloratadina lahko zaznamo že v 30 minutah po uporabi zdravila.
English: Efficacy of Aerius oral solution has not been investigated in separate paediatric trials.
Slovenian: Učinkovitosti zdravila Aerius peroralna raztopina niso raziskovali v ločenih pediatričnih preskušanjih.
English: Talk to your doctor, pharmacist or nurse before taking Aerius: - if you have poor kidney function.
Slovenian: Pred začetkom jemanja zdravila Aerius se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro: - če vam ledvice slabo delujejo.
English: In a pharmacokinetic trial in which patient demographics were comparable to those of the general seasonal allergic rhinitis population, 4 % of the subjects achieved a higher concentration of desloratadine.
Slovenian: V preskušanjih farmakokinetike zdravila, v kateri so bile demografske značilnosti bolnikov podobne tistim za splošno populacijo s sezonskim alergijskim rinitisom, so pri 4 % preiskovancev dosegli višje koncentracije desloratadina.
English: 1 film-coated tablet 2 film-coated tablets 3 film-coated tablets 5 film-coated tablets 7 film-coated tablets 10 film-coated tablets 14 film-coated tablets 15 film-coated tablets 20 film-coated tablets 21 film-coated tablets 30 film-coated tablets 50 film-coated tablets 90 film-coated tablets 100 film-coated tablets
Slovenian: 1 filmsko obložena tableta 2 filmsko obloženi tableti 3 filmsko obložene tablete 5 filmsko obloženih tablet 7 filmsko obloženih tablet 10 filmsko obloženih tablet 14 filmsko obloženih tablet 15 filmsko obloženih tablet 20 filmsko obloženih tablet 21 filmsko obloženih tablet 30 filmsko obloženih tablet 50 filmsko obloženih tablet 90 filmsko obloženih tablet 100 filmsko obloženih tablet
English: Fertility There are no data available on male and female fertility.
Slovenian: Plodnost Podatkov o plodnosti pri moških in ženskah ni na voljo.
English: BOTTLE OF 30 ML, 50 ML, 60 ML, 100 ML, 120 ML, 150 ML, 225 ML, 300 ML
Slovenian: STEKLENIČKA PO 30 ML, 50 ML, 60 ML, 100 ML, 120 ML, 150 ML, 225 ML, 300 ML
English: 5 orodispersible tablets 6 orodispersible tablets 10 orodispersible tablets 12 orodispersible tablets 15 orodispersible tablets 18 orodispersible tablets 20 orodispersible tablets 30 orodispersible tablets 50 orodispersible tablets 60 orodispersible tablets 90 orodispersible tablets 100 orodispersible tablets
Slovenian: 5 orodisperzibilnih tablet 6 orodisperzibilnih tablet 10 orodisperzibilnih tablet 12 orodisperzibilnih tablet 15 orodisperzibilnih tablet 18 orodisperzibilnih tablet 20 orodisperzibilnih tablet 30 orodisperzibilnih tablet 50 orodisperzibilnih tablet 60 orodisperzibilnih tablet 90 orodisperzibilnih tablet 100 orodisperzibilnih tablet
English: Thus, since the course of allergic rhinitis/chronic idiopathic urticaria and the profile of desloratadine are similar in adults and paediatric patients, desloratadine efficacy data in adults can be extrapolated to the paediatric population.
Slovenian: Ker sta potek alergijskega rinitisa oz. kronične idiopatske urtikarije ter profil desloratadina pri otrocih in mladostnikih ter odraslih podobna, lahko torej podatke o učinkovitosti desloratadina za odrasle ekstrapoliramo na otroke in mladostnike.
English: Efficacy of Aerius syrup has not been investigated in paediatric trials in children less than 12 years of age.
Slovenian: Učinkovitosti zdravila Aerius sirup niso raziskovali v pediatričnih preskušanjih pri otrocih, mlajših od 12 let.
English: The collective analysis of preclinical and clinical irritation studies for the orodispersible tablet indicate that this formulation in unlikely to pose risk for local irritation with clinical use.
Slovenian: Skupna analiza zbranih podatkov iz predkliničnih in kliničnih študij draženja pri uporabi orodisperzibilnih tablet je pokazala, da pri tej formulaciji ni skoraj nikakršnega tveganja za lokalno draženje med klinično uporabo zdravila.
English: After oral administration, desloratadine selectively blocks peripheral histamine H1-receptors because the substance is excluded from entry to the central nervous system.
Slovenian: Po peroralni uporabi selektivno zavira le periferne receptorje H1, saj učinkovina ne prehaja v osrednji živčni sistem.
English: MSD Danmark ApS Tlf: + 45 4482 4000 dkmail@merck.com
Slovenian: Danmark MSD Danmark ApS Tlf: + 45 4482 4000 dkmail@merck.com