FrancophonIA/ELRC3.0 huggingface dataset:
English: During INCIVO treatment, rash events (all grades) were reported in 55% of patients who received INCIVO combination treatment and in 33% of patients who received peginterferon alfa and ribavirin.
Danish: Under INCIVO-behandlingen rapporteredes der om hændelser med udslæt (af alle grader) hos 55% af de patienter, som fik INCIVOkombinationsbehandling, og hos 33% af de patienter, som kun fik pegyleret interferon-alfa og
English: Table 7 shows the response rates for the recommended T12/PR and the Pbo/PR48 groups.
Danish: I tabel 7 vises responsraterne for de anbefalede T12/PR- og Pbo/PR48-grupper.
English: HCV/HBV (hepatitis B virus) co-infection There are no data on the use of INCIVO in patients with HCV/HBV co-infection.
Danish: Samtidig infektion med hepatitis C og hepatitis B-virus Der foreligger ingen data om anvendelse af INCIVO til patienter, som er co-inficeret med både
English: In placebo-controlled Phase 2 and 3 clinical trials, the overall incidence and severity of anaemia increased with INCIVO combination treatment compared to peginterferon alfa and ribavirin alone.
Danish: I kliniske placebokontrollede fase 2- og 3-studier øgedes den samlede incidens og sværhedsgrad af anæmi med INCIVO-kombinationsbehandling sammenlignet med pegyleret interferon-alfa og ribavirin alene.
English: What INCIVO looks like and contents of the pack Film-coated tablet.
Danish: Udseende og pakningsstørrelser Filmovertrukne tabletter.
English: In placebo-controlled Phase 2 and 3 trials, anaemia (all grades) was reported in 32.1% of patients who received INCIVO combination treatment and in 14.8% of patients who received peginterferon alfa and ribavirin.
Danish: I placebokontrollerede fase 2- og 3-studier rapporteredes anæmi (af alle grader) hos 32,1% af de patienter, som fik INCIVO-kombinationsbehandling, og hos 14,8% af de patienter, som kun fik pegyleret interferon-alfa og ribavirin.
English: Patients with undetectable HCV RNA (target not detected) at weeks 4 and 12
Danish: Patienter med ikke-detekterbart HCV-RNA (HCV-RNA ikke påvist) i uge 4 og 12
English: Excipient: 2.3 mg of sodium per film-coated tablet.
Danish: Hjælpestof, som behandleren skal være opmærksom på: 2,3 mg natrium pr. filmovertrukket tablet.
English: No relevant induction by telaprevir of CYP1A2, CYP2B6, CYP2C, and CYP3A isozymes was observed in vitro.
Danish: In vitro fandtes der ingen relevant telaprevir-relateret induktion af CYP1A2-, CYP2B6-, CYP2C- og CYP3A-isozymer.
English: Haemoglobin should be monitored at regular intervals prior to and during INCIVO combination treatment (see section 4.4, Laboratory tests).
Danish: Hæmoglobin bør kontrolleres med jævne mellemrum før og under kombinationsbehandling med INCIVO (se pkt.
English: On-treatment virologic failure was defined as meeting a virologic stopping rule and/or having viral breakthrough.
Danish: Virologisk svigt under behandlingen blev defineret som udløsning af en virologisk stopregel og/eller med viralt
English: In placebo-controlled Phase 2 and 3 trials, the overall incidence and severity of rash increased when INCIVO was co-administered with peginterferon alfa and ribavirin.
Danish: I placebokontrollerede fase 2og 3-studier steg den samlede incidens og sværhedsgrad af udslæt, når INCIVO blev givet sammen med pegyleret interferon-alfa og ribavirin.
English: Refer also to the Summary of Product Characteristics for ribavirin for patients with CrCL < 50 ml/min
Danish: Der henvises også til produktresuméet for ribavirin vedrørende patienter med CrCl < 50 ml/min (se også
English: This medicine contains 2.3 mg sodium per tablet, which should be taken into consideration by patients on a controlled sodium diet. Tell your doctor if you have to take care of your salt intake and follow a
Danish: Dette lægemiddel indeholder 2,3 mg natrium pr. tablet, og patienter, som får en diæt med kontrolleret natriumindhold, skal tage hensyn hertil.
English: If co-administered, no dose adjustment is required.
Danish: Dosisjustering er ikke nødvendig ved co-administration.
English: During the INCIVO/placebo treatment phase, the most frequently reported ADRs of at least Grade 3 in the INCIVO group (incidence ≥ 1.0%) were anaemia, rash, thrombocytopenia, lymphopenia,
Danish: Under fasen med INCIVO-/placebo-behandling var de hyppigst rapporterede bivirkninger (incidens ≥ 1,0%) i INCIVO-gruppen, som havde en sværhedsgrad på mindst grad 3, anæmi, udslæt, trombocytopeni, lymfopeni, pruritus og kvalme.
English: hypromellose acetate succinate, calcium hydrogen phosphate (anhydrous), microcrystalline cellulose, silica colloidal anhydrous, sodium lauryl sulphate, croscarmellose sodium, sodium polyvinyl alcohol, macrogol, talc, titanium dioxide (E171), iron oxide yellow (E172)
Danish: Hypromelloseacetatsuccinat, calciumhydrogenphosphat (vandfrit), mikrokrystallinsk cellulose, vandfri kolloid silica, natriumlaurilsulfat, croscarmellosenatrium, natriumstearylfumarat.
English: At the initiation and discontinuation of INCIVO treatment, doses of co-administered tacrolimus or cyclosporine A need to be markedly adjusted (see sections 4.4 and 4.5, Immunosuppressants).
Danish: Ved indledning og seponering af behandling med INCIVO skal doser af co-administreret tacrolimus eller ciclosporin justeres markant (se pkt.
English: If the missed dose is noticed more than 4 hours after the time INCIVO should be taken, the missed dose should be skipped and the patient should resume the normal dosing schedule.
Danish: Hvis det først opdages mere end 4 timer efter det sædvanlige tidspunkt for indgift af INCIVO, skal den glemte dosis springes over, og det sædvanlige behandlingsskema følges.
English: abacavir, efavirenz, tenofovir disoproxil to treat HIV infections (reverse transcriptase inhibitors) to lower cholesterol levels (HMG CoA reductase inhibitors) all types of hormonal contraceptives (‘the pill') hormonal contraceptives hormone replacement therapy to lower your immune system (immunosuppressants), medicines used in some rheumatic diseases or to avoid problems with organ transplants to improve breathing for asthma (inhaled beta agonists) to treat type II diabetes (blood glucose lowering medicine) for the treatment of opioid (narcotic) dependence to treat erectile dysfunction or to treat a heart and lung disorder called pulmonary arterial hypertension (PDE-5 inhibitors)
Danish: til at behandle hiv-infektioner (revers transkriptasehæmmere) fluvastatin, pitavastatin, pravastatin, rosuvastatin til at sænke kolesteroltallet (HMG-CoAreduktasehæmmere) hormonale kontraceptiva hormonsubstitution/hormonterapi medicin til at undertrykke immunsystemet (immunsupprimerende midler), medicin mod visse gigtsygdomme eller til at undgå problemer ved organtransplantation salmeterol til at forbedre vejrtrækningen ved astma (betaagonister til inhalation)
English: Recommendations for Monitoring of Cutaneous Reactions and Discontinuation of INCIVO, Ribavirin and Peginterferon alfa for Severe Rash
Danish: Anbefalinger for overvågning af kutane reaktioner og seponering af behandling med INCIVO, ribavirin og pegyleret interferon-alfa ved alvorligt udslæt
English: The resistance profile observed in Study HPC3006 in treatment-naïve and treatment-experienced HCV-1 infected liver transplant recipients who were on a stable regimen of the immunosuppressants tacrolimus or cyclosporine A was similar to the resistance profile in HCV-infected patients without a liver transplant.
Danish: Den observerede resistensprofil i studie HPC3006 hos behandlingsnaive og behandlingserfarne HCV-1-inficerede levertransplantatmodtagere i stabil behandling med de immunsupprimerende midler tacrolimus eller ciclosporin svarede til resistensprofilen hos HCV-inficerede patienter, der ikke havde gennemgået en levertransplantation.
English: Push the plastic screw cap down while turning it counter clockwise.
Danish: Plastbeholderen er forsynet med et børnesikret låg, der åbnes som følger: - Tryk plastskruelåget ned, mens det drejes mod uret.
English: Following completion of INCIVO therapy contraceptive recommendations should be followed as in the Summary of Product Characteristics for ribavirin, and as described below.
Danish: Efter afslutningen af INCIVO-behandlingen skal kontraceptionsrekommendationerne i produktresumeet for ribavirin følges
English: Study 106 was a randomised, double-blind, placebo-controlled, Phase 2 study that enrolled patients who had failed prior treatment with peginterferon alfa-2a and ribavirin or peginterferon alfa-2b and ribavirin.
Danish: Studie 106 var et randomiseret, dobbeltblindt, placebokontrolleret, fase 2-studie med patienter, som oplevede behandlingssvigt med pegyleret interferon-alfa-2a og ribavirin eller pegyleret interferon-alfa-2b og ribavirin.
English: dexamethasone if taken by mouth or through to treat asthma or to treat inflammatory and autoimmune conditions (corticosteroids)
Danish: budesonid, fluticason til inhalation eller som næsespray, dexamethason der indtages gennem til at behandle astma, betændelsestilstande eller autoimmune lidelser (kortikosteroider)
English: If medically indicated, earlier interruption or discontinuation of peginterferon alfa and ribavirin may be needed.
Danish: Der kan opstå medicinsk indikation for tidligere indstilling eller seponering af pegyleret interferonalfa og ribavirin.
English: All patients received 12 weeks of treatment with INCIVO in combination with peginterferon alfa-2a and ribavirin.
Danish: Alle patienter fik 12 ugers behandling med INCIVO i kombination med pegyleret interferon-alfa-2a og ribavirin.
English: INCIVO must not be taken alone and must be taken in combination with peginterferon alfa and ribavirin to be sure your treatment works.
Danish: INCIVO må ikke tages alene, men skal anvendes sammen med pegyleret interferon-alfa og ribavirin for at sikre, at behandlingen virker.
English: No dose adjustment of INCIVO is required in stable liver transplant patients (see sections 4.8 and 5.1).
Danish: Det er ikke nødvendigt at justere INCIVO-dosis hos stabile levertransplanterede patienter (se pkt.
English: Ribavirin dose reductions were used for management of anaemia.
Danish: Anæmi blev behandlet ved at reducere doseringen af ribavirin.
English: Patients who had undetectable HCV RNA (target not detected) at weeks 4 and 12 received 24 weeks of peginterferon alfa-2a and ribavirin treatment, and patients who did not have undetectable HCV RNA (target not detected) at week 4 and week 12 received 48 weeks of peginterferon alfa-2a and ribavirin treatment.
Danish: Patienter, som havde ikkedetekterbart HCV-RNA (HCV-RNA ikke påvist) i uge 4 og 12, fik 24 ugers behandling med pegyleret interferon-alfa-2a og ribavirin, og patienter, som havde påviseligt HCV-RNA (HCV-RNA ikke påvist) i uge 4 og uge 12 fik 48 ugers behandling med pegyleret interferon-alfa-2a og ribavirin.
English: Because INCIVO must be used in combination with peginterferon alfa and ribavirin, the contraindications and warnings applicable to those medicinal products are applicable to combination therapy.
Danish: Eftersom INCIVO skal anvendes i kombination med pegyleret interferon-alfa og ribarivin, gælder kontraindikationerne og advarslerne for disse lægemidler også for kombinationsbehandlingen.
English: Pregnancy and breast-feeding If you are pregnant, you must not take INCIVO.
Danish: Du må ikke tage INCIVO, hvis du er gravid.
English: These guidelines may not perform similarly when a lead-in treatment with peginterferon alfa and ribavirin has been used prior to starting INCIVO therapy (see section 5.1).
Danish: Denne vejledning fungerer muligvis ikke tilsvarende, når der er anvendt en indledende behandling med pegyleret interferon-alfa og ribavirin (lead-in) før start på
English: - Patients with undetectable hepatitis C virus ribonucleic acid (HCV RNA) (target not detected) at weeks 4 and 12 receive an additional 12 weeks of peginterferon alfa and ribavirin alone for a total treatment duration of 24 weeks.
Danish: - Patienter med ikke-detekterbar hepatitis C-virus-ribonukleinsyre (HCV-RNA) (HCV-RNA ikke påvist) i uge 4 og 12 skal behandles i yderligere 12 uger med pegyleret interferon-alfa og ribavirin alene, så den samlede behandlingsvarighed bliver 24 uger.
English: Permanent and immediate discontinuation of INCIVO, peginterferon alfa, and ribavirin.
Danish: Omgående og permanent seponering af INCIVO, pegyleret interferon-alfa og ribavirin.
English: At week 12, INCIVO dosing ended and patients continued on peginterferon alfa-2a and ribavirin treatment.
Danish: Efter 12 uger stoppede administration af INCIVO, og patienterne fortsatte behandling med pegyleret interferon-alfa-2a og ribavirin.
English: INCIVO must not be administered as monotherapy and must only be prescribed in combination with both peginterferon alfa and ribavirin.
Danish: INCIVO må ikke gives som monoterapi, men skal ordineres i kombination med både pegyleret interferon-alfa og ribavirin.
English: Anorectal signs and symptoms
Danish: Symptomer i anus og rektum
English: Caution is warranted and clinical monitoring is recommended when co-administered with INCIVO.
Danish: Forsigtighed tilrådes, og klinisk monitorering anbefales ved samtidig anvendelse af INCIVO.
English: Caution is warranted and clinical monitoring is recommended.
Danish: Forsigtighed tilrådes, og klinisk monitorering anbefales.
English: Patients with undetectable HCV RNA ( target not detected) at weeks 4 and 12 were randomised at week 20 to receive either 24 weeks or 48 weeks of peginterferon alfa-2a and ribavirin treatment.
Danish: Patienter med ikke-detekterbart HCV-RNA (HCV-RNA ikke påvist) i uge 4 og 12 blev randomiseret i uge 20 til behandling i enten 24 uger eller 48 uger med pegyleret interferon-alfa-2a og ribavirin.
English: INCIVO must not be restarted if discontinued by your doctor.
Danish: Du må ikke begynde at tage INCIVO igen, hvis din læge har afbrudt behandlingen.
English: See section 4.4 for recommendations for monitoring of rash and discontinuation of INCIVO, ribavirin, and peginterferon alfa.
Danish: 4.4 vedrørende anbefalinger for kontrol af udslæt og seponering af behandling med INCIVO, ribavirin og pegyleret interferon-alfa.
English: Treatment-naive patients or prior relapsers who were non-cirrhotic and achieved extended rapid virologic response (eRVR) received 12 weeks of treatment with INCIVO plus peginterferon alfa-2a and ribavirin followed by 12 weeks of treatment with peginterferon alfa-2a and ribavirin (total treatment duration of 24 weeks).
Danish: Behandlingsnaive patienter og tidligere relapsers, som ikke havde cirrose, og som opnåede hurtig virologisk respons (eRVR), fik behandling med INCIVO plus peginterferon alfa-2a og ribavirin i 12 uger efterfulgt af 12 ugers behandling med peginterferon alfa-2a og ribavirin (samlet behandlingsvarighed 24 uger).
English: Since INCIVO treatment always needs to be used together with peginterferon alfa and ribavirin, please also check the package leaflets for the dosage instructions of these medicines.
Danish: Da INCIVO altid skal anvendes sammen med pegyleret interferon-alfa og ribavirin, er det vigtigt, at du også læser afsnittene om dosisvejledninger i indlægssedlerne for disse lægemidler.
English: Table 17: Treatment outcome in genotype 1 HCV-infected liver transplant recipients (Study HPC3006)
Danish: Tabel 17: Behandlingsresultater hos levertransplantatmodtagere inficeret med HCV
English: The difference in SVR rates (95% confidence interval) between the T12/PR and Pbo/PR groups was 33 (26, 39).
Danish: Forskellen i SVR-rater (95% konfidensinterval) mellem T12/PR
English: All patients received 12 weeks of INCIVO in combination with the peginterferon alfa/ribavirin standard therapy.
Danish: Alle patienter fik INCIVO i 12 uger i kombination med standardbehandling med pegyleret interferon-alfa/ribavirin.
English: Treatment-naive patients and prior relapsers who did not achieve eRVR, prior partial responders, prior null responders, and all cirrhotic patients received 12 weeks of treatment with INCIVO plus peginterferon alfa-2a and ribavirin followed by 36 weeks of treatment with peginterferon alfa-2a and ribavirin (total treatment duration of 48 weeks).
Danish: Behandlingsnaive patienter og tidligere relapsers, som ikke opnåede eRVR, tidligere partial responders, tidligere null responders og alle patienter med cirrose fik behandling i 12 uger med INCIVO plus peginterferon alfa-2a og ribavirin efterfulgt af 36 ugers behandling med peginterferon alfa-2a og ribavirin (samlet behandlingsvarighed 48 uger).
English: Relapse was defined as having detectable plasma HCV RNA from planned end of treatment onwards after previous HCV RNA < 25 IU/ml at planned end of HCV treatment, and not achieving SVR12.
Danish: Relaps blev defineret som havende detekterbart plasma-HCV RNA fra det planlagte tidspunkt for behandlingsafslutning og fremefter efter tidligere at have haft HCV RNA < 25 IE/ml på det planlagte tidspunkt for HCV-behandlingsafslutning og manglende opnåelse af SVR12.
English: Plasma concentrations of telaprevir can be reduced by concomitant use of the herbal preparation St John's wort (Hypericum perforatum).
Danish: Telaprevirs plasmakoncentration kan blive reduceret ved samtidig brug af plantelægemidlet perikon (Hypericum perforatum), og naturmedicin, der indeholder perikon, må derfor ikke kombineres med
English: All treatment regimens had a 48-week duration of peginterferon alfa-2a and ribavirin treatment.
Danish: Alle behandlingsregimer omfattede 48 ugers behandling med pegyleret interferon-alfa-2a og ribavirin.
English: These active substances include alfuzosin, amiodarone, bepridil, quinidine, astemizole, terfenadine, cisapride, pimozide, ergot derivatives (dihydroergotamine, ergonovine, ergotamine, methylergonovine), lovastatin, simvastatin, atorvastatin, sildenafil or tadalafil (only when used for treatment of pulmonary arterial hypertension), quetiapine and orally administered midazolam or triazolam (see section 4.5).
Danish: Disse aktive stoffer omfatter alfuzosin, amiodaron, bepridil, quinidin, astemizol, terfenadin, cisaprid, pimozid, sekalealkaloider (dihydroergotamin, ergometrin, ergotamin, methylergometrin), lovastatin,
English: a Grade ≥ 2) that represent a worsening from baseline and are considered adverse drug reactions in HCV-infected patients treated with INCIVO combination treatment from the pooled data from the placebo-controlled
Danish: a) som udgør en forværring fra baseline og anses for bivirkninger hos HCV-inficerede patienter, der får INCIVOkombinationsbehandling, fra de poolede data fra de placebokontrollerede fase 2- og 3-studier Grad 3
English: Other includes patients with detectable HCV RNA at their actual end of treatment but who did not meet the definition of on-treatment virologic failure, and patients with a missing HCV RNA assessment during planned follow-up.
Danish: Andet omfatter patienter med detekterbart HCV RNA på det faktiske tidspunkt for behandlingsafslutning, men som ikke opfyldte definitionen af virologisk svigt under behandlingen, samt patienter med manglende HCV RNAvurdering under den planlagte opfølgning.
English: In placebo-controlled Phase 2 and 3 trials, severe rash (primarily eczematous, pruritic and involving more than 50% body surface area) was reported in 4.8% of patients who received INCIVO combination treatment compared to 0.4% receiving peginterferon alfa and ribavirin.
Danish: I placebokontrollerede fase 2- og 3-studier forekom alvorligt udslæt (primært eksematøst og kløende udslæt, der berører over 50% af legemsoverfladen) hos 4,8% af de patienter, der fik INCIVOkombinationsbehandling, sammenlignet med 0,4% af dem, der fik pegyleret interferon-alfa og ribavirin.
English: Other includes patients with detectable HCV RNA at the planned end of treatment but who did not have viral breakthrough, and patients with a missing SVR assessment during planned follow-up.
Danish: Andet omfatter patienter med detekterbart HCV-RNA på det planlagte tidspunkt for behandlingsafslutning, men som ikke fik et viralt gennembrud, samt patienter med manglende SVR-vurdering under den planlagte opfølgning.
English: Figure 1: Duration of treatment for treatment-naïve patients and prior treatment
Danish: Figur 1: Behandlingsvarighed for behandlingsnaive patienter og patienter med tilbagefald efter tidligere behandling (tidligere relapsers)
English: BOTTLE LABEL (1-bottle pack)
Danish: BEHOLDERENS ETIKET (pakning med 1 beholder)
English: The rash may take several weeks to resolve.
Danish: Der kan gå flere uger, før udslættet er væk.
English: 5.3 Preclinical safety data
Danish: Langtids-effektdata
English: If you need help, ask your doctor or pharmacist.
Danish: Er du i tvivl, så spørg lægen eller på apoteket.
English: Co-administration of rifampicin with telaprevir is contraindicated.
Danish: Samtidig brug af rifampicin og telaprevir er kontraindiceret.
English: It is not recommended to co-administer sildenafil or vardenafil and telaprevir.
Danish: Sildenalfil eller vardenafil anbefales ikke anvendt sammen med telaprevir.
English: Use of peginterferon alfa 2a or 2b Two types of peginterferon alfa (2a and 2b) were studied in the Phase 2a open label, randomised
Danish: Anvendelse af pegyleret interferon-alfa-2a eller -2b To typer pegyleret interferon-alfa (2a og 2b) blev undersøgt i det åbne, randomiserede fase 2a-studie C208 hos behandlingsnaive patienter.
English: - For all patients with cirrhosis irrespective of undetectable HCV RNA (target not detected) at weeks 4 or 12, an additional 36 weeks of peginterferon alfa and ribavirin alone for a total treatment duration of 48 weeks is recommended (see section 5.1).
Danish: - For alle patienter med cirrose, uanset om de har ikke-detekterbart HCV-RNA (HCV-RNA ikke påvist) i uge 4 eller 12, anbefales supplerende behandling i 36 uger med pegyleret interferon-alfa og ribavirin alene, så den samlede behandlingsvarighed bliver 48 uger (se
English: Co-administration of INCIVO and medicinal products that inhibit CYP3A and/or P-gp may increase telaprevir plasma concentrations.
Danish: Samtidig anvendelse af INCIVO og lægemidler, der hæmmer CYP3A og/eller P-gp, kan øge
English: CYP3A and organic anion transporter polypeptides (OATPs) by telaprevir
Danish: bosentan medfører induktion af CYP3A, telaprevis hæmmer CYP3A og organisk aniontransportpolypeptider (OATP)
English: See also the package leaflets for peginterferon alfa and ribavirin.
Danish: Se også indlægssedlen for pegyleret interferon-alfa og ribavirin.
English: In the C211 Phase 3 clinical trial, there was no difference in the type of emerging variants between patients receiving telaprevir 1,125 mg twice daily (b.i.d.)
Danish: I det kliniske fase 3-studie C211 var der ingen forskel mellem den type varianter, der opstod hos patienter, som fik telaprevir 1.125 mg to gange dagligt, og typen hos patienter, som fik telaprevir 750 mg hver 8. time.
English: Patients in these studies, 108, 111 and C216, had compensated liver disease, detectable HCV RNA, and liver histopathology consistent with chronic hepatitis C. Unless otherwise indicated, INCIVO was administered at a dosage of 750 mg every 8 hours (q8h); the peginterferon alfa-2a dose was 180 µg/week, and the ribavirin dose was 1,000 mg/day (patients weighing < 75 kg) or 1,200 mg/day (patients weighing ≥ 75 kg).
Danish: Patienterne i disse studier, 108, 111 og C216, havde kompenseret leversygdom, påviseligt HCV-RNA, og lever-histopatologi svarende til kronisk hepatitis C. Med mindre andet angives, blev INCIVO givet i en dosis på 750 mg hver 8. time.
English: Relapse was defined as having HCV RNA ≥ 25 IU/ml during the follow-up period after previous HCV RNA < 25 IU/ml at planned end of treatment and not achieving SVR12.
Danish: Relaps blev defineret som havende HCV RNA ≥ 25 IE/ml i opfølgningsperioden efter tidligere at have haft HCV RNA < 25 IE/ml på det planlagte tidspunkt for behandlingsafslutning og manglende opnåelse af SVR12.
English: All patients received 12 weeks of treatment with INCIVO plus peginterferon alfa-2a and ribavirin followed by 36 weeks of treatment with peginterferon alfa-2a and ribavirin (total treatment duration of 48 weeks).
Danish: Alle patienter fik INCIVO plus pegyleret interferon alfa-2a og ribavirin i 12 uger, efterfulgt af pegyleret interferon alfa-2a og ribavirin i 36 uger (samlet behandlingsvarighed 48 uger).