FrancophonIA/ELRC3.0 huggingface dataset:
English: In this study, the majority of patients (79%) mixed their short acting insulin with NPH insulin immediately prior to injection and 58% of subjects used oral hypoglycaemic agents at randomization and were instructed to continue to use them at the same dose.
Slovenian: Večina bolnikov (79 %) v tej študiji je kratkodelujoči insulin tik pred injiciranjem zmešala z insulinom NPH, 58% preiskovancev pa je ob randomizaciji uporabljalo peroralne antidiabetike in so dobili navodilo, naj jih v enakem odmerku uporabljajo še naprej.
English: Beta-blockers like other sympatholytic medicines (such as clonidine, guanethidine and reserpine) may weaken or suppress entirely the first warning symptoms which help you to recognise a hypoglycaemia.
Slovenian: Zaviralci adrenergičnih receptorjev beta lahko, tako kot druga simpatikolitična zdravila (kot so klonidin, gvanetidin in reserpin), oslabijo ali popolnoma preprečijo prve opozorilne simptome, ki vam pomagajo prepoznati hipoglikemijo.
English: Insulin glulisine for intravenous use at a concentration of 1 Unit/ml is stable between 15°C and 25°C for 48 hours (see section 6.6).
Slovenian: Insulin glulisin za intravensko uporabo je v koncentraciji 1 enota/ml pri temperaturi od 15°C do 25°C stabilen 48 ur (glejte poglavje 6.6).
English: Step 1 Check the insulin
Slovenian: 1. korak; Preverite insulin
English: Apidra is a short-acting insulin.
Slovenian: Apidra je kratkodelujoč insulin.
English: The glucose excursion (AUC 0-6h) was 641 mg.h.dl-1 for insulin glulisine and 801 mg.h.dl-1 for regular human insulin.
Slovenian: Ekskurz glukoze (AUC 0-6h) je bil pri insulinu glulisin 641 mg.h.dl-1 in pri navadnem humanem insulinu 801 mg.h.dl-1.
English: Needles must not be reused.
Slovenian: Igel ne smete ponovno uporabiti.
English: Severe hypoglycaemic episodes, where the patient has become unconscious, can be treated by glucagon (0.5 mg to 1 mg) given intramuscularly or subcutaneously by a person who has received appropriate instruction, or by glucose given intravenously by a healthcare professional.
Slovenian: Hude hipoglikemije, ko je bolnik nezavesten, je mogoče zdraviti z intramuskularno ali subkutano injekcijo glukagona (0,5 mg do 1 mg), ki jo da ustrezno usposobljena oseba, ali z intravensko injekcijo glukoze, ki jo da zdravstveni delavec.
English: Figure 1B
Slovenian: slika 1B
English: Do not use Apidra
Slovenian: Ne uporabljajte zdravila Apidra
English: If you think you may have a problem with Apidra, have it checked by your doctor or pharmacist.
Slovenian: Če se vam zdi, da imate težave z zdravilom Apidra, naj ga pregleda vaš zdravnik ali farmacevt.
English: These are serious side effects.
Slovenian: To so resni neželeni učinki.
English: Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu/
Slovenian: DATUM ZADNJE REVIZIJE BESEDILA Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/
English: If your blood sugar level starts to rise, contact your doctor, pharmacist or nurse as soon as possible.
Slovenian: Če se vam začne krvni sladkor zviševati, se čim prej posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Keep this possible problem in mind in all situations where you might put yourself and others at risk (such as driving a car or using machines).
Slovenian: Ne pozabite na to v okoliščinah, v katerih bi lahko ogrozili sebe in druge (kot je vožnja avtomobila ali upravljanje strojev).
English: However, hypoglycaemia may develop over sequential stages.
Slovenian: A hipoglikemija se lahko razvije v dveh zaporednih stopnjah:
English: Hypoglycaemia, the most frequent adverse reaction of insulin therapy, may occur if the insulin dose is too high in relation to the insulin requirement.
Slovenian: Hipoglikemija, ki je najpogostejši neželeni učinek zdravljenja z insulinom, se pojavi, če je odmerek insulina prevelik glede na potrebo po insulinu.
English: Step 4 Select the dose
Slovenian: Korak 4 Izberite odmerek
English: The used SoloStar must be discarded as required by your local authorities.
Slovenian: Porabljeni SoloStar morate zavreči v skladu z lokalnimi predpisi.
English: Apidra is a clear insulin.
Slovenian: Apidra je bister insulin.
English: The primary activity of insulins and insulin analogues, including insulin glulisine, is regulation of glucose metabolism.
Slovenian: Temeljno delovanje insulinov in insulinskih analogov, tudi insulina glulisin, je uravnavanje presnove glukoze.
English: In insulin glulisine the replacement of the human insulin amino acid asparagine in position B3 by lysine and the lysine in position B29 by glutamic acid favours more rapid absorption.
Slovenian: V insulinu glulisin je aminokislina asparagin na položaju B3 humanega insulina nadomeščena z lizinom, lizin na položaju B29 pa z glutaminsko kislino; to zagotavlja hitrejšo absorpcijo.
English: You should contact your doctor for advice on driving if: - you have frequent episodes of hypoglycaemia, - the first warning symptoms which help you to recognise hypoglycaemia are reduced or absent.
Slovenian: Z zdravnikom se pogovorite glede vožnje, če: - imate pogoste hipoglikemije, - so prvi opozorilni znaki hipoglikemije šibki ali jih sploh nimate.
English: The infusion set and reservoir used with Apidra must be changed at least every 48 hours using aseptic technique.
Slovenian: Komplet za infundiranje in rezervoar, ki se uporabljata z zdravilom Apidra, je treba zamenjati vsaj na 48 ur; pri tem je treba uporabljati aseptičen postopek.
English: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products except NPH human insulin.
Slovenian: Zaradi pomanjkanja študij kompatibilnosti, tega zdravila ne smemo mešati z drugimi zdravili razen s humanim insulinom NPH.
English: When you use Apidra in the pump system, it is important that you always follow these specific instructions.
Slovenian: Če uporabljate zdravilo Apidra v sistemu s črpalko, je pomembno, da vedno upoštevate specifična navodila za zdravilo Apidra.
English: Special patient groups If you have liver or kidney problems, speak to your doctor as you may need a lower dose.
Slovenian: Pogovorite se z zdravnikom, če imate težave z jetri ali ledvicami, ker morda potrebujete nižji odmerek.
English: Apidra 100 Units/ml solution for injection in a vial For further details on handling, see section 6.6.
Slovenian: Apidra 100 enot/ml raztopina za injiciranje v viali Za dodatne podrobnosti o ravnanju glejte poglavje 6.6.
English: Figure 1C
Slovenian: slika 1C
English: Mixing with insulins
Slovenian: Mešanje z insulini
English: Hyperglycaemia (potentially leading to Diabetic ketoacidosis(1))
Slovenian: Hiperglikemija (ki lahko vodi v diabetično ketoacidozo
English: If you switch from another insulin to insulin glulisine, your dosage may have to be adjusted by your doctor.
Slovenian: Če na insulin glulisin preidete z drugega insulina, vam bo zdravnik morda moral prilagoditi odmerek.
English: You should always have an alternative insulin delivery system available for injection under the skin in case the pump system fails.
Slovenian: Vedno morate imeti na voljo še drug insulin za injiciranje pod kožo za primer, da sistem s črpalko odpove.
English: Hypoglycaemia (low blood sugar) means that there is not enough sugar in the blood.
Slovenian: Hipoglikemija (nizka koncentracija krvnega sladkorja) pomeni, da v krvi ni dovolj sladkorja.
English: Cases of diabetic ketoacidosis have been reported when Apidra has been given in continuous subcutaneous insulin infusion in pump systems.
Slovenian: Primeri diabetične ketoacidoze so bili opisani, če je bilo zdravilo Apidra uporabljeno za kontinuirano subkutano infundiranje insulina v sistemih s črpalko.
English: Failure to follow Apidra specific instructions may lead to serious adverse events.
Slovenian: Neupoštevanje specifičnih navodil za zdravilo Apidra lahko povzroči resne neželene učinke.
English: Elderly Very limited pharmacokinetic data are available for elderly patients with diabetes mellitus.
Slovenian: Starejši Na voljo so le zelo omejeni podatki o farmakokinetiki pri starejših bolnikih z diabetesom mellitusom.
English: Apidra contains metacresol, which may cause allergic reactions.
Slovenian: Zdravilo Apidra vsebuje metakrezol, ki lahko povzroči alergijske reakcije.
English: INFORMATION IN BRAILLE Apidra
Slovenian: PODATKI V BRAILLOVI PISAVI Apidra
English: In controlled clinical studies in adults, insulin glulisine did not show differences in safety and efficacy in subgroup analyses based on race and gender.
Slovenian: V kontroliranih kliničnih preizkušanjih pri odraslih se varnost in učinkovitost insulina glulisin v analizah podskupin po starosti in spolu nista razlikovali.
English: Do not stop Apidra without speaking to a doctor, who will tell you what needs to be done.
Slovenian: Ne prenehajte zdravljenja z zdravilom Apidra, ne da bi se pogovorili z zdravnikom.
English: What Apidra looks like and contents of the pack
Slovenian: Izgled zdravila Apidra in vsebina pakiranja
English: SoloStar has to be used as recommended in these Instructions for use (see section 6.6).
Slovenian: SoloStar uporabljajte kot je priporočeno v navodilih za ravnanje z injekcijskim peresnikom (glejte poglavje 6.6).
English: Apidra contains metacresol Apidra contains metacresol, which may cause allergic reactions.
Slovenian: Apidra vsebuje metakrezol Zdravilo Apidra vsebuje metakrezol, ki lahko povzroči alergijske reakcije.
English: Read and follow the instructions that come with your insulin infusion pump.
Slovenian: Preberite in upoštevajte navodila, priložena vaši črpalki za infundiranje insulina.
English: If you forget to use Apidra
Slovenian: Če ste pozabili uporabiti zdravilo Apidra
English: They may include cold sweats, cool pale skin, fatigue, nervousness or tremor, anxiousness, unusual tiredness or weakness, confusion, difficulty in concentration, drowsiness, excessive hunger, vision changes, headache, nausea and palpitation.
Slovenian: Obsegajo lahko hladno znojenje, hladno in bledo kožo, izčrpanost, živčnost ali tremor, anksioznost, nenavadno utrujenost ali šibkost, zmedenost, težave s koncentracijo, zaspanost, čezmerno lakoto, spremembe vida, glavobol, navzeo in palpitacije.
English: The pen must not be soaked, washed or lubricated as this may damage it.
Slovenian: Injekcijskega peresnika ne smete namakati, umivati ali mazati, ker ga s tem lahko poškodujete.
English: The patient should always follow the Apidra specific instructions and always have access to alternative insulin delivery system in case of pump system failure.
Slovenian: Bolnik mora vedno upoštevati specifična navodila za uporabo zdravila Apidra in mora vedno imeti na voljo še drug sistem za dajanje insulina za primer, da sistem s črpalko odpove.
English: Continuous subcutaneous infusion pump Refer to section 4.2 and 4.4 for advice.
Slovenian: Stalno subkutano infundiranje s črpalko Glejte poglavji 4.2 in 4.4.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bil lahko bili noseči ali načrtujete zanositev, se posvetujte s svojim zdravnikom ali s farmacevtom, preden vzamete to zdravilo.
English: These could be symptoms of severe cases of generalised allergy to insulin, including anaphylactic reaction, which may be life-threatening.
Slovenian: To so lahko znaki generalizirane alergije na insulin, vključno z anafilaktično reakcijo, ki je lahko smrtno nevarna.
English: If you experience the following symptoms, contact your doctor immediately:
Slovenian: Takoj povejte zdravniku, če izkusite sledeče simptome:
English: If you stop using Apidra
Slovenian: Če ste prenehali uporabljati zdravilo Apidra
English: Severe cases of generalized allergy, including anaphylactic reaction, may be life-threatening.
Slovenian: Hudi primeri generaliziranih alergij, vključno z anafilaktičnimi reakcijami, so lahko smrtno nevarni.
English: A number of substances affect glucose metabolism and may require dose adjustment of insulin glulisine and particularly close monitoring.
Slovenian: Na presnovo glukoze vplivajo številna zdravila; potrebna utegneta biti prilagoditev odmerka insulina glulisin in posebno natančno nadziranje.
English: Hyperglycaemia (high blood sugar) means that there is too much sugar in the blood.
Slovenian: Hiperglikemija (visok krvni sladkor) pomeni, da je v krvi preveč sladkorja.
English: Packs of 1, 2, 4 and 5 vials are available.
Slovenian: Na voljo so pakiranja z 1, 2, 4 in 5 vialami.
English: To prevent the possible transmission of disease, each pen must be used by one patient only.
Slovenian: Da preprečite možen prenos bolezni, sme vsak injekcijski peresnik uporabljati samo en bolnik.
English: Malfunction of the insulin pump or infusion set or handling errors can rapidly lead to hyperglycaemia, ketosis and diabetic ketoacidosis.
Slovenian: Nepravilno delovanje insulinske črpalke ali kompleta za infundiranje, ali napake pri ravnanju lahko hitro povzročijo hiperglikemijo, ketozo in diabetično ketoacidozo.
English: Studies in healthy volunteers and patients with diabetes demonstrated that insulin glulisine is more rapid in onset of action and of shorter duration of action than regular human insulin when given subcutaneously.
Slovenian: Študije pri zdravih prostovoljcih in bolnikih z diabetesom so pokazale, da začne insulin glulisin po subkutani uporabi delovati hitreje in deluje krajši čas kot navadni humani insulin.
English: Continuous subcutaneous insulin infusion
Slovenian: Kontinuirano subkutano infundiranje insulina
English: Your doctor may tell you to use it in combination with an intermediate, long-acting insulin, a basal insulin or with tablets used to treat high blood sugar levels.
Slovenian: Zdravnik vam bo morda naročil, da ga uporabljate v kombinaciji s srednjedolgo-, dolgodelujočim insulinom, z bazalnim insulinom ali s tabletami, ki se uporabljajo za zdravljenje visokih koncentracij krvnega sladkorja.
English: B. Line up the needle with the pen, and keep it straight as you attach it (screw or push on,
Slovenian: B. Naravnajte iglo z injekcijskim peresnikom in jo držite naravnost, medtem ko jo nameščate (privijte jo ali jo potisnite, odvisno od vrste igle).
English: If administration by syringe, intravenous injection or infusion pump is necessary, a vial should be used (see section 4.4).
Slovenian: Če je potrebno dajanje z injekcijsko brizgo, intravensko injekcijo ali infuzijsko črpalko, je treba uporabiti vialo (glejte poglavje 4.4).
English: Recommended safety measures for removal and disposal of needles must be followed (e.g. a one handed capping technique) in order to reduce the risk of accidental needle injury and transmission of infectious diseases.
Slovenian: Upoštevajte priporočene varnostne ukrepe, ko igle odstranjujete in zavržete (npr. tehniko pokrivanja z eno roko), da boste zmanjšali tveganje za naključno poškodbo z iglo in prenos nalezljivih bolezni.
English: The distribution and elimination of insulin glulisine and regular human insulin after intravenous administration is similar with volumes of distribution of 13 l and 22 l and half-lives of 13 and 18 minutes, respectively.
Slovenian: Porazdelitev in izločanje insulina glulisin in navadnega humanega insulina sta po intravenski uporabi podobni: volumen porazdelitve je pri prvem 13 l in pri drugem 22 l, razpolovni čas pa pri prvem 13 minut in pri drugem 18 minut.
English: Read carefully the "SoloStar Instructions for use" included in this package leaflet.
Slovenian: Natančno preberite "Navodila za ravnanje s SoloStarjem", ki jih vključuje to navodilo.
English: You may need to use Apidra with syringes or pens.
Slovenian: Morda boste morali zdravilo Apidra uporabiti z injekcijskimi brizgami ali injekcijskimi peresniki.
English: In a clinical study performed in non-diabetic subjects covering a wide range of renal function (CrCl >80 ml/min, 30-50 ml/min, <30 ml/min), the rapid-acting properties of insulin glulisine were generally maintained.
Slovenian: V klinični študiji pri nediabetičnih preiskovancih z zelo različnim delovanjem ledvic (očistek kreatinina > 80 ml/min, 30-50 ml/min, < 30 ml/min) se je hitro delovanje insulina glulisin praviloma ohranilo.
English: Insulin glulisine was shown to be comparable to regular human insulin with regard to glycated haemoglobin (expressed as HbA1c equivalent) changes from baseline to the 6-month endpoint (-0.46% for insulin glulisine and -0.30% for regular human insulin, p=0.0029) and from baseline to the 12-month endpoint (-0.23% for insulin glulisine and -0.13% for regular human insulin, difference not significant).
Slovenian: Insulin glulisin je primerljiv navadnemu humanemu insulinu, kar zadeva spremembo glikiranega hemoglobina (izraženo kot ekvivalent HbA1c) od izhodišča do končne točke po 6-ih mesecih (-0,46 % za insulin glulisin in -0,30 % za navadni humani insulin, p = 0,0029) in od izhodišča do končne točke po 12-ih mesecih (-0,23 % za insulin glulisin in -0,13 % za navadni humani insulin, razlika ni značilna).
English: They can also spread around the injection site.
Slovenian: Te reakcije se lahko razširijo tudi okoli mesta injiciranja.
English: Comparable self-monitored blood glucose values were observed.
Slovenian: Ugotovili so tudi primerljive vrednosti glukoze v krvi, izmerjene s samokontrolo.
English: Check the insulin A. Check the label on your SoloStar to make sure you have the correct insulin.
Slovenian: A. Preverite nalepko na injekcijskem peresniku SoloStar, da se boste prepričali, ali imate pravi insulin.
English: When insulin glulisine is injected subcutaneously, the glucose lowering activity will begin within 10-20 minutes.
Slovenian: Po subkutanem injiciranju insulina glulisin se učinek na zniževanje glukoze pojavi v 10 do 20 minutah.
English: • Always have a spare SoloStar in case your SoloStar is lost or damaged.
Slovenian: • Vedno imejte na zalogi rezerven SoloStar, če injekcijski peresnik izgubite ali se poškoduje.
English: There are no or limited amount of data (less than 300 pregnancy outcomes) from the use of insulin glulisine in pregnant women.
Slovenian: Podatkov o uporabi insulina glulisin pri nosečnicah ni oziroma so na voljo le omejene količine podatkov (manj kot 300 izidov nosečnosti).
English: Administered immediately before a test meal, insulin glulisine provided better postprandial control than regular human insulin, as in adults (see section 5.1).
Slovenian: Insulin glulisin, apliciran tik pred testnim obrokom, je zagotovil boljšo postprandialno urejenost kot navadni humani insulin, tako kot pri odraslih (glejte poglavje 5.1).
English: GLULISINE LISPRO REGULAR
Slovenian: GLULISIN LISPRO NAVADNI
English: Apidra should be used at a concentration of 1 Unit/ml insulin glulisine in infusion systems with sodium chloride 9 mg/ml (0.9%) solution for infusion with or without 40 mmol/l potassium chloride using coextruded polyolefin/polyamide plastic infusion bags with a dedicated infusion line.
Slovenian: Zdravilo Apidra je treba v koncentraciji 1 enota/ml insulina glulisin uporabiti v infuzijskih sistemih z 0,9 % (9 mg/ml) raztopino natrijevega klorida za infundiranje, s 40 mmol/l kalijevega klorida ali brez njega, ter z uporabo koekstrudiranih plastičnih infuzijskih vrečk iz poliolefina/poliamida in namensko infuzijsko linijo.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Subcutaneous use.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Za subkutano uporabo.
English: A phase I study carried out with insulin glulisine, lispro and regular human insulin in an obese population has demonstrated that insulin glulisine maintains its rapid-acting properties.
Slovenian: Študija faze I, opravljena z insulinom glulisin, insulinom lispro in navadnim humanim insulinom pri populaciji debelih preiskovancev, je pokazala, da insulin glulisin ohrani svoje hitro delovanje.
English: The label on the pen should be checked to make sure it contains the correct insulin.
Slovenian: Preveriti morate oznako na injekcijskem peresniku in se tako prepričati, da vsebuje pravi insulin.
English: The time to 10% of total INS exposure was reached earlier by approximately 5-6 min with insulin glulisine.
Slovenian: Z insulinom lispro je bila 10 % skupna INS izpostavljenost dosežena približno 5-6 minut hitreje.
English: If SoloStar is in cool storage, it should be taken out 1 to 2 hours before you inject to allow it to warm up.
Slovenian: Če je SoloStar shranjen na hladnem, ga morate vzeti iz hladilnika 1 do 2 uri pred injiciranjem, da se ogreje.
English: OTHER SPECIAL WARNING(S), IF NECESSARY Use only clear and colourless solutions.
Slovenian: DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA Raztopino uporabite le, če je bistra in brezbarvna.
English: After removing the pen cap, the appearance of insulin should also be checked: the insulin solution must be clear, colourless, with no solid particles visible, and must have a water-like consistency.
Slovenian: Po odstranitvi pokrovčka injekcijskega peresnika je treba preveriti videz insulina: raztopina insulina mora biti bistra, brezbarvna, brez vidnih delcev in vodi podobne konsistence.
English: Hydrochloric acid, concentrated Sodium hydroxide Water for injections
Slovenian: koncentrirana klorovodikova kislina, natrijev hidroksid, voda za injekcije.
English: Figure 2: Glucose infusion rates (GIR) after subcutaneous injection of 0.3 Units/kg of insulin glulisine (GLULISINE) or insulin lispro (LISPRO) or regular human insulin (REGULAR) in an obese population.
Slovenian: Slika 2: Hitrost infundiranja glukoze (GIR) po subkutani injekciji 0,3 enot/kg insulina glulisin (GLULISIN) ali insulina lispro (LISPRO) ali navadnega humanega insulina (NAVADNI) pri debelih preiskovancih.
English: When insulin glulisine was injected subcutaneously into abdomen, deltoid and thigh, the concentration-time profiles were similar with a slightly faster absorption when administered in the abdomen compared to the thigh.
Slovenian: Po subkutanem injiciranju insulina glulisin v trebuh, deltoidni predel in stegno je bil profil časovnega poteka koncentracije podoben, z nekoliko hitrejšo absorpcijo po aplikaciji v trebuh kot po aplikaciji v stegno.
English: Apidra should be given by subcutaneous injection shortly (0-15 min) before or soon after meals or by continuous subcutaneous pump infusion.
Slovenian: Zdravilo Apidra se uporablja v subkutani injekciji tik (0-15 minut) pred obroki ali kmalu po njih ali stalni subkutani infuziji s črpalko.
English: When mixed with NPH human insulin, Apidra should be drawn into the syringe first.
Slovenian: V primeru mešanja s humanim insulinom NPH, je treba insulin Apidra v brizgo potegniti najprej.
English: Before using Apidra in the pump system you should have been given detailed instructions on how to use the pump system.
Slovenian: Preden insulin Apidra uporabite v sistemu s črpalko, morate dobiti izčrpna navodila o uporabi črpalke.
English: A. Use the injection method as instructed by your doctor, pharmacist or nurse.
Slovenian: A. Uporabite postopek injiciranja, ki vam ga je pokazal vaš zdravnik, farmacevt ali medicinska sestra..
English: Important information about some of the ingredients of Apidra This medicine contains less than 1 mmol (23 mg) sodium per dose, i.e. it is essentially ‘sodium-free'.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Apidra To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni brez natrija.
English: Breast-feeding mothers may require adjustments in insulin dose and diet.
Slovenian: Pri doječih materah utegne biti potrebna prilagoditev odmerka insulina in prehrane.
English: What Apidra is and what it is used for
Slovenian: Kaj je zdravilo Apidra in za kaj ga uporabljamo
English: What Apidra is and what it is used for What you need to know before you use Apidra How to use Apidra
Slovenian: Kaj je zdravilo Apidra in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Apidra Kako uporabljati zdravilo Apidra Možni neželeni učinki