FrancophonIA/ELRC3.0 huggingface dataset:
English: Tamiflu can also be used as preventative treatment in exceptional cases, for instance when the seasonal flu vaccine may not provide sufficient protection and when there is a pandemic (a global epidemic of flu).
Croatian: Lijek Tamiflu može se primjenjivati i kao preventivna terapija u iznimnim slučajevima, primjerice ako sezonsko cjepivo protiv gripe možda ne pruža dovoljnu zaštitu i ako vlada pandemija (globalna epidemija gripe).
English: Tamiflu received a marketing authorisation valid throughout the EU on 20 June 2002.
Croatian: Lijek Tamiflu dobio je odobrenje za stavljanje u promet koje je na snazi u EU-u od 20. lipnja 2002.
English: Tamiflu is available as capsules (30 mg, 45 mg, and 75 mg) and as a powder that is made up into a liquid to be drunk (6 mg/ml and 12 mg/ml).
Croatian: Tamiflu je dostupan u obliku kapsula (30 mg, 45 mg i 75 mg) i u prahu od kojeg se priprema tekućina za oralnu primjenu (6 mg/ml i 12 mg/ml).
English: What measures are being taken to ensure the safe and effective use of Tamiflu?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Tamiflu?
English: In adults, the duration of the illness was reduced from an average of 5.2 days for patients taking placebo, to 4.2 days for patients taking Tamiflu.
Croatian: U odraslih je osoba trajanje bolesti skraćeno s prosječnih 5,2 dana za bolesnike koji uzimaju placebo na 4,2 dana za bolesnike koji uzimaju Tamiflu.
English: The medicine contains the active substance oseltamivir.
Croatian: Lijek sadrži djelatnu tvar oseltamivir.
English: The usual dose for adults and children weighing more than 40 kg is 75 mg given once a day for at least 10 days after contact with an infected person.
Croatian: Uobičajena doza za odrasle osobe i djecu tjelesne težine veće od 40 kg iznosi 75 mg jedanput na dan tijekom najmanje 10 dana nakon kontakta sa zaraženom osobom.
English: Side effects reported with Tamiflu are carefully evaluated and any necessary action taken to protect patients.
Croatian: Nuspojave prijavljene za lijek Tamiflu pažljivo se procjenjuju i poduzimaju se potrebne mjere za zaštitu bolesnika.
English: It can also reduce the incidence of flu in patients who had come into contact with the disease or during a pandemic.
Croatian: Lijek isto tako može smanjiti incidenciju gripe u bolesnika koji su bili u kontaktu s bolešću ili tijekom pandemije.
English: A study also looked at using Tamiflu in a family setting (277 families) for both the treatment of the person with flu, and the treatment or prevention of flu in those in contact with the person.
Croatian: U ispitivanju se također promatrala primjena lijeka Tamiflu u obiteljskom okruženju (277 obitelji) za liječenje osobe zaražene gripom, ali i liječenje ili prevenciju gripe u osoba koje su u kontaktu s tom osobom.
English: Tamiflu reduced the incidence of flu in people who had come into contact with the disease when one of their family members contracted flu (962 cases) or during an epidemic (1,562 people aged between 16 and 65 years, and 548 elderly people in nursing homes).
Croatian: Lijek Tamiflu smanjio je incidenciju gripe u osoba koje su bile u kontaktu s bolešću ako je jedan član njihove obitelji zaražen gripom (962 slučaja) ili tijekom epidemije (1 562 osobe u dobi između 16 i 65 godina i 548 starije osobe u domovima za starije i nemoćne osobe).
English: Tamiflu is an antiviral medicine used to treat or prevent influenza (flu).
Croatian: Tamiflu je antivirusni lijek za liječenje ili prevenciju influence (gripe):
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Tamiflu have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Tamiflu nalaze se u sažetku opisa svojstava i u uputi o lijeku.
English: Oseltamivir works on the neuramidases of both influenza A (the most common type) and influenza B viruses.
Croatian: Oseltamivir djeluje na neuraminidaze oba virusa, influence A (najčešćeg tipa) i influence B.
English: When used for treatment of flu, Tamiflu reduces the duration of illness in adults and children.
Croatian: Kada se primjenjuje u liječenju gripe, lijek Tamiflu skraćuje trajanje bolesti u odraslih osoba i djece.
English: In families with one patient who had flu, 7% of the family members in the household developed flu when receiving Tamiflu, compared with 20% of those receiving no preventative treatment.
Croatian: U obiteljima u kojima je jedan bolesnik imao gripu, 7 % članova obitelji u kućanstvu dobilo je gripu nakon uzimanja lijeka Tamiflu, u usporedbi s 20 % osoba koje nisu uzimale preventivnu terapiju.
English: • to treat flu, it can be used in adults and children (including full-term newborns) who have the symptoms of flu, when the flu virus is circulating in the community;
Croatian: • u svrhu liječenja gripe primjenjuje se u odraslih osoba i djece (uključujući novorođenčad rođenu na vrijeme) koji imaju simptome gripe, kada se virus gripe širi u zajednici;
English: In the study carried out during an epidemic, 1% of the people taking Tamiflu developed flu after contact, compared with 5% of those taking placebo.
Croatian: U ispitivanju provedenom tijekom epidemije, 1 % osoba koje su uzimale Tamiflu dobilo je gripu nakon kontakta, u usporedbi s 5 % onih koji su uzimali placebo.
English: Tamiflu reduced the duration of the illness compared with placebo (a dummy treatment) in several studies (involving 2,413 patients aged 13 years or over, 741 elderly patients aged 65 years or over and 1,033 children aged between 1 and 12 years).
Croatian: Lijek Tamiflu skratio je trajanje bolesti u usporedbi s placebom (prividno liječenje) u nekoliko ispitivanja (na 2 413 bolesnika u dobi od 13 godina i starijih, 741 starijeg bolesnika u dobi od 65 godina ili starijih i u 1 033 djece u dobi između jedne godine i 12 godina).
English: Why is Tamiflu authorised in the EU?
Croatian: Zašto je Tamiflu odobren u EU-u?
English: As for all medicines, data on the use of Tamiflu are continuously monitored.
Croatian: Kao i za sve lijekove, podatci o primjeni lijeka Tamiflu kontinuirano se prate.
English: What is Tamiflu and what it is used for?
Croatian: Što je Tamiflu i za što se primjenjuje?
English: When Tamiflu is used during a flu epidemic, it is given for up to 6 weeks.
Croatian: Ako se Tamiflu primjenjuje tijekom epidemije gripe, može se primjenjivati do šest tjedana.
English: The European Medicines Agency decided that Tamiflu's benefits are greater than its risks and recommended that it can be authorised for use in the EU.
Croatian: Europska agencija za lijekove zaključila je da koristi od lijeka Tamiflu nadmašuju s njim povezane rizike te da lijek može biti odobren za primjenu u Europskoj uniji.
English: Other information about Tamiflu
Croatian: Ostale informacije o lijeku Tamiflu
English: During a flu pandemic, Tamiflu can also be used to prevent flu in babies below 1 year of age.
Croatian: Tijekom pandemije gripe, Tamiflu se može primjenjivati i za prevenciju gripe kod beba mlađih od godinu dana.
English: The active substance in Tamiflu, oseltamivir, acts on the flu virus, blocking some of the enzymes on its surface known as neuramidases.
Croatian: Djelatna tvar lijeka Tamiflu, oseltamivir, djeluje na virus gripe tako da inhibira neuraminidaze, određene enzime na njegovoj površini.
English: For more information about using Tamiflu, see the package leaflet or contact your doctor or pharmacist.
Croatian: Više informacija o primjeni lijeka Tamiflu pročitajte u uputi o lijeku, odnosno obratite se liječniku ili ljekarniku.
English: The most common side effects with Tamiflu (seen in more than 1 patient in 10) in adults and adolescents are headache and nausea (feeling sick).
Croatian: Najčešće nuspojave povezane s lijekom Tamiflu (zabilježene u više od 1 na 10 bolesnika) u odraslih osoba i adolescenata jesu glavobolja i mučnina (slabost).
English: What are the risks associated with Tamiflu?
Croatian: Koji su rizici povezani s lijekom Tamiflu?
English: • to prevent flu, it can be used in adults and children over 1 year of age who have been in contact with someone who has flu and flu is circulating in the community.
Croatian: • radi prevencije gripe može se primjenjivati u odraslih osoba i djece starije od jedne godine koji su bili u kontaktu s osobom oboljelom od gripe i ako u zajednici kruži gripa.
English: In children the most common side effects (seen in more than 1 patient in 10) are vomiting, cough and nasal congestion (a blocked nose).
Croatian: Najčešće nuspojave u djece (zabilježene u više od 1 na 10 bolesnika) jesu povraćanje, kašalj i nazalna kongestija (začepljenost nosa).
English: An overview of Tamiflu and why it is authorised in the EU
Croatian: Pregled informacija o lijeku Tamiflu i zašto je odobren u EU-u
English: In the prevention of flu, Tamiflu must be started within two days of contact with someone who has flu.
Croatian: Za prevenciju gripe terapiju lijekom Tamiflu treba započeti unutar dva dana od kontakta s osobom koja ima gripu.
English: In the treatment of flu, Tamiflu must be started within two days of the onset of symptoms.
Croatian: Tijekom liječenja gripe primjenu lijeka Tamiflu treba započeti unutar dva dana od nastupa simptoma.
English: What benefits of Tamiflu have been shown in studies?
Croatian: Koje su koristi od lijeka Tamiflu utvrđene u ispitivanjima?
English: How does Tamiflu work?
Croatian: Kako djeluje Tamiflu?
English: For the full list of side effects and restrictions with Tamiflu, see the package leaflet.
Croatian: Potpuni popis nuspojava i ograničenja pri primjeni lijeka Tamiflu potražite u uputi o lijeku.
English: This is generally done on a caseby-case basis.
Croatian: Primjena lijeka u načelu ovisi o pojedinačnom slučaju.
English: How is Tamiflu used?
Croatian: Kako se Tamiflu primjenjuje?
English: Patients can inject the medicine themselves after being trained.
Croatian: Bolesnici si mogu sami ubrizgavati lijek nakon što prođu odgovarajuću obuku.
English: EMA/CHMP/249688/2019 EMEA/H/C/004447
Croatian: EMA/191978/2019 EMEA/H/C/004447
English: Further information on Aimovig can be found on the Agency's website: ema.europa.eu/medicines/human/EPAR/aimovig.
Croatian: Više informacija o lijeku Aimovig nalazi se na internetskim stranicama Agencije: ema.europa.eu/medicines/human/EPAR/aimovig.
English: Aimovig received a marketing authorisation valid throughout the EU on 26 July 2018.
Croatian: Lijek Aimovig dobio je odobrenje za stavljanje u promet koje je na snazi na prostoru EU-a od 26. srpnja 2018.
English: The recommended dose is 70 mg every 4 weeks as a single injection.
Croatian: Preporučena doza je 70 mg svaka četiri tjedna u obliku jedne injekcije.
English: Most of the side effects are mild or moderate in severity.
Croatian: Većina nuspojava bila je blage ili umjerene težine.
English: Some patients may benefit from a dose of 140 mg every 4 weeks, given as either a single injection of 140 mg or two injections of 70 mg.
Croatian: Neki bolesnici mogu imati koristi od doze od 140 mg svaka četiri tjedna koja se primjenjuje ili kao jednokratna injekcija od 140 mg ili kao dvije injekcije od 70 mg.
English: What is Aimovig and what is it used for?
Croatian: Što je Aimovig i za što se koristi?
English: What measures are being taken to ensure the safe and effective use of Aimovig?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Aimovig?
English: Aimovig can only be obtained with a prescription and treatment should be started by a doctor experienced in the diagnosis and treatment of migraine.
Croatian: Aimovig se izdaje samo na liječnički recept, a liječenje mora započeti liječnik s iskustvom u dijagnosticiranju i liječenju migrene.
English: Side effects reported with Aimovig are carefully evaluated and any necessary action taken to protect patients.
Croatian: Nuspojave prijavljene za lijek Aimovig pažljivo se procjenjuju i poduzimaju se potrebne mjere za zaštitu bolesnika.
English: The most common side effects with Aimovig (which may affect up to 1 in 10 people) are reactions at the site of injection, constipation, muscle spasms and itching.
Croatian: Najčešće nuspojave lijeka Aimovig (koje se mogu javiti u najviše 1 na 10 osoba) su reakcije na mjestu injekcije, zatvor, grčevi u mišićima i svrbež.
English: By attaching to this receptor, the medicine stops CGRP from attaching to it and causing migraine.
Croatian: Vezivanjem na taj receptor lijek onemogućuje da se na njega veže CGRP i izazove migrenu.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Aimovig have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Aimovig nalaze se u sažetku opisa svojstava i u uputi o lijeku.
English: The European Medicines Agency therefore decided that Aimovig's benefits are greater than its risks and it can be authorised for use in the EU.
Croatian: Europska agencija za lijekove stoga je zaključila da koristi od lijeka Aimovig nadmašuju s njim povezane rizike te da lijek može biti odobren za primjenu u Europskoj uniji.
English: Other information about Aimovig
Croatian: Ostale informacije o lijeku Aimovig
English: The active substance in Aimovig, erenumab, is a monoclonal antibody (a type of protein) designed to attach to a receptor (target) for CGRP on body's cells.
Croatian: Djelatna tvari lijeka Aimovig, erenumab, monoklonsko je protutijelo (vrsta bjelančevine) osmišljeno za vezivanje na receptor (cilj) za CGRP na stanicama u tijelu.
English: Aimovig is a medicine used to prevent migraine in adults who have migraines at least 4 days a month.
Croatian: Aimovig je lijek koji se primjenjuje za sprječavanje migrene u odraslih osoba koje imaju migrenu najmanje četiri dana mjesečno.
English: As for all medicines, data on the use of Aimovig are continuously monitored.
Croatian: Kao za sve lijekove, podatci o primjeni lijeka Aimovig kontinuirano se prate.
English: An overview of Aimovig and why it is authorised in the EU
Croatian: Pregled informacija o lijeku Aimovig i zašto je odobren u EU-u
English: What are the risks associated with Aimovig?
Croatian: Koji su rizici povezani s lijekom Aimovig?
English: Aimovig (erenumab) EMA/CHMP/249688/2019
Croatian: Aimovig (erenumab) EMA/191978/2019
English: Aimovig is injected under the skin using a pre-filled syringe or pen.
Croatian: Aimovig se ubrizgava pod kožu s pomoću napunjene štrcaljke ili brizgalice.
English: Why is Aimovig authorised in the EU?
Croatian: Zašto je lijek Aimovig odobren u EU-u?
English: In a second study of 955 patients who had migraines 8 days a month on average, those treated with Aimovig had on average 3 to 4 fewer days with migraines per month compared with around 2 fewer days for patients on placebo.
Croatian: U drugom ispitivanju koje je obuhvatilo 955 bolesnika koji su u prosjeku imali migrenu osam dana mjesečno, bolesnici liječeni lijekom Aimovig iskusili su u prosjeku tri do četiri dana s migrenom manje, u usporedbi s otprilike dva dana manje u bolesnika koji su primali placebo.
English: How is Aimovig used?
Croatian: Kako se Aimovig koristi?
English: For more information about using Aimovig, see the package leaflet or contact your doctor or pharmacist.
Croatian: Više informacija o primjeni lijeka Aimovig pročitajte u uputi o lijeku, odnosno obratite se liječniku ili ljekarniku.
English: In a study of 667 patients who had migraines 18 days a month on average, those treated with Aimovig had 7 fewer days with migraines per month, compared with 4 fewer days for patients on placebo.
Croatian: U ispitivanju koje je obuhvatilo 667 bolesnika koji su u prosjeku imali migrenu 18 dana mjesečno, bolesnici liječeni lijekom Aimovig iskusili su sedam dana s migrenom manje, u usporedbi s četiri dana manje u bolesnika koji su primali placebo.
English: A chemical messenger called CGRP has been shown to be involved in the development of migraine.
Croatian: Dokazano je da je u nastajanje migrene uključen kemijski glasnik naziva CGRP.
English: Only patients with migraines at least 4 days a month were included in the studies as patients with less frequent migraines are not usually eligible for preventative treatment.
Croatian: Ispitivanja su obuhvatila samo bolesnike koji imaju migrenu najmanje četiri dana mjesečno jer preventivno liječenje uglavnom nije prikladno u bolesnika u kojih su migrene rjeđe.
English: Aimovig is effective at reducing the number of days patients suffer migraines.
Croatian: Aimovig je djelotvoran u smanjivanju broja dana kada bolesnici imaju migrenu.
English: Aimovig was shown to be effective at reducing the number of days patients have migraines.
Croatian: Lijek Aimovig pokazao se djelotvornim u smanjivanju broja dana kada bolesnici imaju migrenu.
English: What benefits of Aimovig have been shown in studies?
Croatian: Koje su koristi od lijeka Aimovig utvrđene u ispitivanjima?
English: For the full list of side effects and restrictions of Aimovig, see the package leaflet.
Croatian: Potpuni popis nuspojava i ograničenja pri primjeni lijeka Aimovig potražite u uputi o lijeku.
English: How does Aimovig work?
Croatian: Kako djeluje Aimovig?
English: Κύπρος Γ.Α.Σταμάτης & Σια Λτδ.
Croatian: Γ.Α.Σταμάτης & Σια Λτδ.
English: Each cycle lasts 21 days.
Croatian: Svaki ciklus traje 21 dan.
English: Contraception (women and men)
Croatian: Kontracepcija (žene i muškarci)
English: These are a type of blood cells.
Croatian: Oni su jedna vrsta krvnih stanica.
English: The safety and efficacy in children and adolescents less than 18 years have not been established.
Croatian: Sigurnost i djelotvornost u djece i adolescenata mlađih od 18 godina nisu ustanovljene.
English: For the treatment to be fully effective, it is very important not to miss a dose.
Croatian: Da bi liječenje postiglo puni učinak, vrlo je važno da ne propustite nijednu dozu.
English: Reactivation of latent infections has been reported.
Croatian: Prijavljena je reaktivacija latentnih infekcija.
English: Irreferi għall-Irlanda
Croatian: Malta Irreferi għall-Irlanda
English: This is because Polivy can affect your baby's health.
Croatian: Naime, Polivy može utjecati na zdravlje Vašeg djeteta.
English: Other medicines and Polivy
Croatian: Drugi lijekovi i Polivy
English: • you are due to have a vaccine or you know you may need to have one in the near future
Croatian: • ako trebate primiti cjepivo ili ako znate da ćete ga možda trebati primiti u bliskoj budućnosti
English: • you have ever had liver problems
Croatian: • ako ste ikada imali jetrenih tegoba
English: It is important to tell your doctor before and during treatment if you are pregnant, think you may be pregnant, or are planning to get pregnant.
Croatian: Važno je da prije i tijekom liječenja obavijestite svog liječnika ako ste trudni, mislite da biste mogli biti trudni ili planirate trudnoću.
English: Pay attention to the following side effects
Croatian: Obratite pozornost na sljedeće nuspojave
English: Polivy will be stored by the healthcare professionals at the hospital or clinic.
Croatian: Polivy će čuvati zdravstveni radnici u bolnici ili klinici.
English: This medicine should not be used in children or young people under the age of 18.
Croatian: Ovaj se lijek ne smije primjenjivati u djece ili osoba mlađih od 18 godina.
English: 10.3 (5.6, NE)
Croatian: 10,3 (5,6; NP)
English: Lonzastrasse CH-3930 Visp Switzerland
Croatian: Lonzastrasse CH-3930 Visp Švicarska
English: If you had any of these symptoms before treatment with Polivy, tell your doctor straight away if you notice any changes in them.
Croatian: Ako ste imali bilo koji od tih simptoma prije liječenja lijekom Polivy, odmah se obratite svom liječniku ako primijetite bilo kakve promjene u njima.
English: You should not use this medicine if you are pregnant unless you and your doctor decide that the benefit to you outweighs possible risk to the unborn baby.
Croatian: Ne smijete primati ovaj lijek ako ste trudni, osim ako Vi i Vaš liječnik ne odlučite da korist liječenja za Vas nadmašuje mogući rizik za nerođeno dijete.
English: • memory loss, trouble speaking, difficulty walking or problems with your eyesight
Croatian: • gubitak pamćenja, otežan govor, poteškoće s hodanjem ili tegobe s vidom
English: Human Immunodeficiency Virus (HIV)
Croatian: Virus humane imunodeficijencije (HIV)
English: Studies have not been conducted in patients who recently received live vaccines.
Croatian: Nisu provedena ispitivanja u bolesnika koji su nedavno primili živa cjepiva.
English: The median age was 69 years (range: 30-86 years).
Croatian: Medijan dobi iznosio je 69 godina (raspon: 30 - 86 godina).
English: These include:
Croatian: One uključuju sljedeće:
English: If you get any serious reaction, your doctor may stop treatment with Polivy.
Croatian: Ako se kod Vas pojavi bilo koja ozbiljna reakcija, Vaš će liječnik možda prekinuti liječenje lijekom Polivy.
English: This is because stopping treatment may make your condition worse.
Croatian: Naime, prekid liječenja mogao bi dovesti do pogoršanja Vašeg stanja.
English: This medicinal product must not be mixed or diluted with other medicinal products except those mentioned in section 6.6.
Croatian: Lijek ne smije miješati niti razrjeđivati s drugim lijekovima osim onih navedenih u dijelu 6.6.
English: The reconstituted solution and solution for infusion should not be frozen or exposed to direct sunlight.
Croatian: Rekonstituirana otopina i otopina za infuziju ne smiju se zamrzavati niti izlagati izravnoj sunčevoj svjetlosti.
English: White to greyish-white lyophilized cake.
Croatian: Bijeli do sivkasto-bijeli liofilizirani kolačić.
English: Do not stop treatment with Polivy unless you have discussed this with your doctor.
Croatian: Nemojte prekinuti liječenje lijekom Polivy ako o tome prethodno niste razgovarali sa svojim liječnikom.
English: Polivy, bendamustine and rituximab can be administered in any order on Day 1 of each cycle.
Croatian: Polivy, bendamustin i rituksimab mogu se primijeniti bilo kojim redoslijedom 1. dana svakog ciklusa.
English: The reconstituted product contains no preservative and is intended for single-dose only.
Croatian: Rekonstituirani lijek ne sadrži konzervanse i namijenjen je za primjenu samo jedne doze.
English: If you have symptoms of peripheral neuropathy, your doctor may lower your dose.
Croatian: Ako imate simptome periferne neuropatije, liječnik će Vam možda smanjiti dozu.
English: These may be new symptoms or a change in your current symptoms.
Croatian: Može se raditi o pojavi novih ili promjeni postojećih simptoma.
English: Your doctor, pharmacist or nurse will do blood tests to check for the condition.
Croatian: Vaš liječnik, ljekarnik ili medicinska sestra provest će krvne pretrage kako bi provjerili imate li navedeno stanje.
English: What Polivy looks like and contents of the pack
Croatian: Kako Polivy izgleda i sadržaj pakiranja
English: MMAE does not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP2D6.
Croatian: MMAE ne inhibira CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 ni CYP2D6.
English: If you stop receiving Polivy
Croatian: Ako prestanete primati Polivy
English: This medicine can cause inflammation or damage to cells in the liver that affect the normal function of the liver.
Croatian: Ovaj lijek može uzrokovati upalu ili oštećenje jetrenih stanica koje utječe na normalnu funkciju jetre.
English: Polivy can cause some serious side effects that you need to tell your doctor or nurse about straight away.
Croatian: Polivy može uzrokovati neke ozbiljne nuspojave o kojima odmah morate obavijestiti svog liječnika ili medicinsku sestru.
English: • The usual starting dose is 1.8 mg for each kilogram of your body weight.
Croatian: • Uobičajena početna doza je 1,8 mg po kilogramu tjelesne težine.
English: This patient had three prior lines of therapy that included anti-CD20 antibodies.
Croatian: Taj je bolesnik prethodno primio tri linije liječenja, koje su uključivale protutijela na CD20.