FrancophonIA/ELRC3.0 huggingface dataset:
English: Your doctor may increase your dose by doubling the dose at intervals of at least 2 weeks up to 32 mg once a day.
Slovenian: Zdravnik vam lahko odmerek poveča s podvojitvijo, vendar v presledkih, ki niso krajši od 2 tednov, in do 32 mg enkrat na dan.
English: • if you have recently had a kidney transplant.
Slovenian: • če so vam pred kratkim presadili ledvico.
English: There were 26.7 events per 1000 patient-years in the candesartan group versus 30.0 events per 1000 patient-years in the control group (relative risk 0.89, 95%CI 0.75 to 1.06, p=0.19).
Slovenian: V skupini s kandesartanom so zabeležili 26,7 dogodka na 1000 bolnik-let, v kontrolni skupini pa 30,0 dogodkov na 1000 bolnik-let (relativno tveganje 0,89, 95 % IZ: od 0,75 do 1,06, p = 0,19).
English: Patients on optimal CHF therapy at baseline were randomised to placebo or candesartan cilexetil (titrated from 4 mg or 8 mg once daily to 32 mg once daily or the highest tolerated dose, mean dose 24 mg) and followed for a median of 37.7 months.
Slovenian: Bolnike, ki so imeli izhodiščno optimalno zdravljenje kroničnega srčnega popuščanja, so naključno razporedili v skupino, ki je prejemala placebo ali v skupino, ki je prejemala cileksetilkandesartanat (s prilagajanjem odmerka od 4 mg ali 8 mg enkrat na dan do 32 mg enkrat na dan ali največjega toleriranega odmerka, povprečni odmerek 24 mg) ter jih spremljali mediano 37,7 meseca.
English: In a pooled analysis of clinical trial data of hypertensive patients, adverse reactions with candesartan cilexetil were defined based on an incidence of adverse events with candesartan cilexetil at least 1% higher than the incidence seen with placebo.
Slovenian: V skupni analizi podatkov kliničnih preskušanj pri hipertenzivnih bolnikih so bili neželeni učinki s cileksetilkandesartanatom opredeljeni kot incidenca neželenih učinkov s cileksetilkandesartanatom vsaj 1 % večja od tiste s placebom.
English: Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter.
Slovenian: Bolniki morajo biti ustrezno hidrirani; po začetku sočasnega zdravljenja in občasno med zdravljenjem jim je treba kontrolirati delovanje ledvic.
English: Very rare Hyponatraemia
Slovenian: Zelo redki hiponatriemija
English: Your doctor may want to see you more often and do some tests if you have any of these conditions.
Slovenian: Če imate katero od teh stanj, vas bo zdravnik morda pogosteje kontroliral in bo opravil nekatere preiskave.
English: the CHMP has recommended the amendment of the Marketing Authorisations for which the Summary of Product Characteristics, labelling and package leaflet are set out in Annex III for Atacand and associated names (see Annex I).
Slovenian: CHMP je priporočil dopolnitev dovoljenj za promet z zdravilom Atacand in z njim povezanimi imeni (glejte Dodatek I), za katere povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo so navedeni v Dodatku III.
English: The use of AIIRAs is contraindicated during the second and third trimesters of pregnancy (see sections 4.3 and 4.4).
Slovenian: Uporaba AIIRA je kontraindicirana v drugem in tretjem trimesečju nosečnosti (glejte poglavji 4.3 in 4.4).
English: If you take more Atacand than prescribed by your doctor, contact a doctor or pharmacist immediately for advice.
Slovenian: Če ste vzeli večji odmerek zdravila Atacand, kot bi smeli Če ste vzeli več zdravila Atacand, kot vam je predpisal zdravnik, se takoj posvetujte z zdravnikom ali s farmacevtom.
English: The area under the serum concentration versus time curve (AUC) of candesartan is not significantly affected by food.
Slovenian: Hrana nima pomembnega vpliva na površino pod krivuljo serumske koncentracije kandesartana po času (AUC).
English: Treatment with candesartan cilexetil resulted in improved NYHA functional class (p=0.020).
Slovenian: Zdravljenje s cileksetilkandesartanat je povzročilo izboljšanje funkcijskega razreda po NYHA (p = 0,020).
English: In the CHARM clinical programme, comparing Atacand in doses up to 32 mg (n=3,803) to placebo (n=3,796), 21.0% of the candesartan cilexetil group and 16.1% of the placebo group discontinued treatment because of adverse events.
Slovenian: V kliničnem programu CHARM, v katerem so Atacand v odmerkih do 32 mg (n = 3.803) primerjali s placebom (n = 3.796), je bil delež prekinitev zaradi neželenih učinkov v skupini s cileksetilkandesartanatom 21,0 % in v skupini s placebom 16,1 %.
English: As with other agents inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible patients treated with Atacand.
Slovenian: Tako kot pri drugih zdravilih, ki zavirajo sistem renin-angiotenzin-aldosteron, je tudi pri občutljivih bolnikih, zdravljenih z Atacandom, mogoče pričakovati spremembe delovanja ledvic.
English: You may notice tiredness, an infection or a fever.
Slovenian: Lahko občutite utrujenost, pojavi se okužba ali zvišana telesna temperatura.
English: Up-titration to the target dose of 32 mg once daily (maximum dose) or the highest tolerated dose is done by doubling the dose at intervals of at least 2 weeks.
Slovenian: Povečevanje odmerka do ciljnega odmerka 32 mg enkrat na dan (največji odmerek) ali do največjega odmerka, ki ga bolniki še dobro prenašajo, poteka tako, da se odmerek podvoji na vsaj 2 tedna.
English: The bioavailability of candesartan is not affected by food.
Slovenian: Hrana ne vpliva na biološko uporabnost kandesartana.
English: In preclinical safety studies candesartan had effects on the kidneys and on red cell parameters at high doses in mice, rats, dogs and monkeys.
Slovenian: V predkliničnih študijah varnosti so veliki odmerki kandesartana pri miših, podganah, psih in opicah vplivali na ledvice in parametre rdečih krvnih celic.
English: The CHMP thus considered that although candesartan can be administered with other heart failure treatment (including ACE inhibitors, beta-blockers, diuretics and digitalis or a combination thereof), the association of an ACE inhibitor, a potassium-sparing diuretic and candesartan is not recommended.
Slovenian: CHMP je zato menil, čeprav se kandesartan lahko daje z drugimi zdravili za srčno popuščanje (vključno z zaviralci ACE, zaviralci beta, diuretiki in digitalisom ali kombinacijami omenjenega), kombinacija zaviralca ACE, diuretika, ki varčuje s kalijem, in kandesartana ni priporočljiva.
English: In patients with mild to moderate renal impairment Cmax and AUC of candesartan increased during repeated dosing by approximately 50% and 70%, respectively, but t½ was not altered, compared to patients with normal renal function.
Slovenian: Pri bolnikih z blago do zmerno okvaro ledvic sta se Cmax in AUC kandesartana med večkratnim odmerjanjem povečali za približno 50 % (Cmax) in 70 % (AUC), t1/2 pa se ni spremenil v primerjavi z bolniki z normalnim delovanjem ledvic.
English: • Feeling dizzy/spinning sensation.
Slovenian: • Omotičnost/vrtoglavica.
English: Bocskai út 134-146
Slovenian: AstraZeneca Kft. 1113 Budapest, Bocskai út 134-146 Hungary
English: However, the CHMP/PhVWP report on the use of ACE inhibitors and Angiotensin II Receptor Antagonists (ARBs) during the 1st trimester of pregnancy (EMEA/CHMP/PhVWP/474692/2007)
Slovenian: Vendar poročilo CHMP/PhVWP o uporabi zaviralcev ACE in antagonistov receptorjev za angiotenzina II v prvem trimesečju nosečnosti (EMEA/CHMP/PhVWP/474692/2007) kaže, da kontraindikacija v prvem trimesečju nosečnosti ni utemeljena; uporaba antagonistov AIIRA v prvem trimesečju nosečnosti ni priporočljiva.
English: Very rare Renal impairment, including renal failure in susceptible patients (see section 4.4)
Slovenian: Zelo redki okvara ledvic, vključno z odpovedjo ledvic pri občutljivih bolnikih (glejte poglavje 4.4)
English: • Low blood pressure.
Slovenian: • Nizek krvni tlak.
English: • Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, diclofenac,
Slovenian: • nesteroidna protivnetna zdravila (NSAID), npr. ibuprofen, naproksen, diklofenak, celekoksib ali etorikoksib (zdravila za lajšanje bolečin in ublažitev vnetja).
English: The CHMP considered that the available clinical data support a dose of candesartan up to 32 mg for the treatment of hypertension.
Slovenian: CHMP je menil, da razpoložljivi klinični podatki za zdravljenje hipertenzije podpirajo odmerek kandesartana do 32 mg. Vključen je bil tudi sklic, da se lahko kandesartan daje tudi z drugimi antihipertenzivnimi zdravili.
English: Hypotension may occur during anaesthesia and surgery in patients treated with angiotensin II antagonists due to blockade of the renin-angiotensin system.
Slovenian: Med anestezijo in operacijami se lahko bolnikom, ki prejemajo antagoniste angiotenzina II, zaradi blokade sistema renin-angiotenzin pojavi hipotenzija.
English: Candesartan is not removed by haemodialysis.
Slovenian: Hemodializa ne odstrani kandesartana.
English: In patients with CHF and depressed left ventricular systolic function (left ventricular ejection fraction, LVEF  40%), candesartan decreases systemic vascular resistance and pulmonary capillary wedge pressure, increases plasma renin activity and angiotensin II concentration, and decreases aldosterone levels.
Slovenian: Pri bolnikih s kroničnim srčnim popuščanjem in oslabljeno sistolično funkcijo levega prekata (iztisni delež levega prekata, LVEF  40 %) kandesartan zniža sistemsko žilno upornost in pljučni kapilarni zagozditveni tlak, poveča aktivnost renina in koncentracijo angiotenzina II v plazmi in zmanjša koncentracijo aldosterona.
English: • Nausea.
Slovenian: • Srbenje.
English: inhibitors such as enalapril, captopril, lisinopril or ramipril.
Slovenian: ACE, npr. enalaprilom, kaptoprilom, lizinoprilom ali ramiprilom.
English: In some patients whose blood pressure is not adequately controlled, the dose can be increased to 16 mg once daily and to a maximum of 32 mg once daily.
Slovenian: Nekaterim bolnikom, ki krvnega tlaka nimajo ustrezno urejenega, je odmerek mogoče povečati na 16 mg enkrat na dan in do največ 32 mg enkrat na dan. Zdravljenje je treba prilagoditi odzivu krvnega tlaka.
English: Concomitant use of potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium, or other medicinal products (e.g. heparin) may increase potassium levels.
Slovenian: Sočasna uporaba diuretikov, ki varčujejo s kalijem, dodatkov kalija, nadomestkov soli, ki vsebujejo kalij, ali drugih zdravil (npr. heparin) lahko povečajo koncentracijo kalija.
English: There was no statistically significant difference in the primary endpoint, major cardiovascular events (cardiovascular mortality, non-fatal stroke and non-fatal myocardial infarction).
Slovenian: Primarna končna točka, pomembni kardiovaskularni dogodki (kardiovaskularna umrljivost, možganska kap brez smrtnega izida in miokardni infarkt brez smrtnega izida), se med skupinama ni statistično značilno razlikovala.
English: Estrada Consiglieri Pedroso, 69 BQueluz de Baixo
Slovenian: Estrada Consiglieri Pedroso, 69 B - Queluz de Baixo 2730-055 Barcarena
English: There was no evidence of abnormal systemic or target organ toxicity at clinically relevant doses.
Slovenian: V klinično pomembnih odmerkih niso ugotovili nenormalnih sistemskih toksičnih učinkov ali toksičnih učinkov na ciljnih organih.
English: • difficulties in breathing, with or without swelling of the face, lips, tongue and/or throat
Slovenian: • težko dihanje - z otekanjem obraza, ustnic, jezika in/ali žrela ali brez otekanja.
English: Concomitant therapy with an ACE inhibitor in heart failure The risk of adverse reactions, especially renal function impairment and hyperkalaemia, may increase when Atacand is used in combination with an ACE inhibitor (see section 4.8).
Slovenian: Sočasno zdravljenje z zaviralcem ACE pri srčnem popuščanju Uporaba Atacanda v kombinaciji z zaviralci ACE lahko poveča tveganje neželenih učinkov, zlasti okvare delovanja ledvic in hiperkaliemije (glejte poglavje 4.8).
English: You can take Atacand with or without food.
Slovenian: Zdravilo Atacand lahko vzamete s hrano ali brez nje.
English: Concomitant use of Atacand with potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (e.g. heparin) may lead to increases in serum potassium in hypertensive patients.
Slovenian: Sočasna uporaba Atacanda in diuretikov, ki varčujejo s kalijem, dodatkov kalija, nadomestkov soli, ki vsebujejo kalij, ali drugih zdravil, ki lahko povečajo koncentracijo kalija v serumu (npr. heparina), lahko pri hipertenzivnih bolnikih povzroči porast kalija v serumu.
English: As with ACE inhibitors, concomitant use of AIIRAs and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Slovenian: Tako kot zaviralci ACE lahko tudi AIIRA, uporabljeni hkrati z nesteroidnimi protivnetnimi zdravili, povečajo tveganje za poslabšanje delovanja ledvic (vključno z akutno odpovedjo ledvic) in povečanje koncentracije kalija v serumu, zlasti pri bolnikih, ki jim ledvice že sicer delujejo slabo.
English: Hypertension indication
Slovenian: Indikacija hipertenzije
English: Treatment of Heart Failure
Slovenian: Zdravljenje srčnega popuščanja
English: Additional wording separating the adverse events (AEs) findings from the CHARM programme was included as it illustrated that AE are more common in subjects who received other medicinal products which affect the renin-angiotensin system (RAS).
Slovenian: Dodano je bilo besedilo, da se ločijo neželeni pojavi iz programa CHARM in prikaže večja pogostnost neželenih pojavov pri preiskovancih, ki so prejemali druga zdravila, ki vplivajo na retikularni aktivacijski sistem.
English: Monitoring of potassium should be undertaken as appropriate (see section 4.4).
Slovenian: Če je primerno, moramo spremljati nivo kalija (glejte poglavje 4.4).
English: Should these agents be less than effective, addition of an ARB or a potassium sparing diuretic should be considered.
Slovenian: Če bi bili ti zdravili manj učinkoviti, je treba proučiti možnost dodatka antagonista receptorjev za angiotenzin ali diuretika, ki varčuje s kalijem.
English: If this is severe you may notice tiredness, weakness, irregular heart beat or pins and needles.
Slovenian: Če je to povečanje hudo, lahko občutite utrujenost, šibkost, neredno bitje srca ali mravljinčenje.
English: Common Renal impairment, including renal failure in susceptible patients (see section 4.4)
Slovenian: Pogosti okvara ledvic, vključno z odpovedjo ledvic pri občutljivih bolnikih (glejte poglavje 4.4)
English: Sympathomimetic medicinal products may be administered if the above-mentioned measures are not sufficient.
Slovenian: Če našteti ukrepi ne zadoščajo, se lahko uporabi simpatikomimetična zdravila.
English: HOW TO TAKE ATACAND
Slovenian: KAKO JEMATI ZDRAVILO ATACAND
English: In line with the referred above, for heart failure patients treated with candesartan, hyperkalaemia may occur.
Slovenian: Glede na opisano se lahko pri bolnikih s srčnim popuščanjem, ki se zdravijo s kandesartanom, pojavi hiperkaliemija.
English: Treatment of Hypertension
Slovenian: Zdravljenje hipertenzije
English: • if you are allergic (hypersensitive) to candesartan cilexetil or any of the other ingredients of Atacand (see section 6).
Slovenian: • če ste alergični na (preobčutljivi za) cileksetilkandesartanat ali katerokoli sestavino zdravila
English: Atacand contains candesartan cilexetil, an angiotensin receptor blocker (ARB), indicated for the treatment of essential hypertension in adults and of adult patients with heart failure and impaired left ventricle systolic function (left ventricular ejection fraction  40%) as add-on therapy to Angiotensin Converting Enzyme (ACE inhibitors) or when ACE inhibitors are not tolerated.
Slovenian: Zdravilo Atacand vsebuje kandesartan cileksetil, antagonist receptorjev za angiotenzin, in je indicirano za zdravljenje odraslih bolnikov z esencialno hipertenzijo ter srčnim popuščanjem in zmanjšano sistolično funkcijo levega prekata (iztisni delež levega prekata  40 %) kot dodatek zdravljenju poleg zaviralcev angiotenzinske konvertaze (zaviralcev ACE) ali kadar bolniki zaviralce ACE slabo prenašajo.
English: Pharmacotherapeutic group: Angiotensin II antagonists, plain, ATC code: C09CA06
Slovenian: Oznaka ATC: C09CA06
English: Netherlands AstraZeneca BV Louis Pasteurlaan 5
Slovenian: AstraZeneca BV Louis Pasteurlaan 5 2719 EE Zoetermeer The Netherlands
English: Tell your doctor if you are breast-feeding or about to start breast-feeding.
Slovenian: Povejte svojemu zdravniku, če dojite ali boste začeli dojiti.
English: Following an oral dose of
Slovenian: Po peroralnem odmerku s
English: Following oral administration, candesartan cilexetil is converted to the active substance candesartan.
Slovenian: Po peroralni uporabi se cileksetilkandesartanat spremeni v zdravilno učinkovino kandesartan.
English: The changes to the SPC have been taken into account in the amendments to the PL and labelling as appropriate.
Slovenian: Spremembe povzetka glavnih značilnosti zdravila so bile po potrebi upoštevane pri dopolnitvah navodila za uporabo in označevanja.
English: During dose titration of Atacand, monitoring of serum creatinine and potassium is recommended.
Slovenian: Med prilagajanjem odmerka Atacanda je priporočljivo kontrolirati kreatinin in kalij v serumu.
English: Effects on the kidneys (such as interstitial nephritis, tubular distension, basophilic tubules; increased plasma concentrations of urea and creatinine) were induced by candesartan which could be secondary to the hypotensive effect leading to alterations of renal perfusion.
Slovenian: Kandesartan je povzročil zmanjšanje parametrov rdečih krvnih celic (eritrociti, hemoglobin, hematokrit), Kandesartan je povzročil učinke na ledvicah (npr. intersticijski nefritis, razširitev tubulov, bazofilne tubule, povečanje koncentracije sečnine in kreatinina v plazmi); ti bi lahko bili sekundarni zaradi hipotenzivnega učinka, ki povzroči spremembe ledvične perfuzije.
English: Because no information is available regarding the use of Atacand during breastfeeding, Atacand is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
Slovenian: Med dojenjem ima prednost nadomestno zdravljenje z dokazanim varnostnim profilom, posebej pri dojenju novorojenčka ali nedonošenčka.
English: • The usual dose of Atacand is 8 mg once a day.
Slovenian: • Običajen odmerek zdravila Atacand je 8 mg enkrat na dan.
English: For therapeutic doses of candesartan in humans, the hyperplasia/hypertrophy of the renal juxtaglomerular cells does not seem to have any relevance.
Slovenian: Hiperplazija/hipertrofija ledvičnih jukstaglomerularnih celic pri terapevtskih odmerkih kandesartana pri človeku po vsem sodeč ni pomembna.
English: What Atacand contains
Slovenian: Kaj vsebuje zdravilo Atacand
English: Hypersensitivity to candesartan cilexetil or to any of the excipients.
Slovenian: Preobčutljivost za cileksetilkandesartanat ali katerokoli pomožno snov.
English: There is no experience regarding the administration of Atacand in patients with a recent kidney transplantation.
Slovenian: Presaditev ledvice Z Atacandom ni izkušenj pri bolnikih, ki jim je bila pred kratkim presajena ledvica.
English: Atacand can be taken together with other medicines for heart failure, and your doctor will decide which treatment is suitable for you.
Slovenian: Zdravnik bo presodil, kakšno zdravljenje je primerno za vas.
English: In heart failure patients treated with Atacand, hyperkalaemia may occur.
Slovenian: Bolnikom s srčnim popuščanjem, ki prejemajo Atacand, se lahko pojavi hiperkaliemija.
English: The recommended initial dose and usual maintenance dose of Atacand is 8 mg once daily.
Slovenian: Priporočeni začetni in običajni vzdrževalni odmerek Atacanda je 8 mg enkrat na dan.
English: Finland AstraZeneca Oy Luomanportti 3
Slovenian: AstraZeneca Oy Luomanportti 3 FI-02200 Espoo Finland
English: Atacand 2, tabletten 2 mg 2 mg
Slovenian: Atacand 2, tabletten 2 mg
English: Periodic monitoring of serum potassium is recommended.
Slovenian: Zato je priporočljivo redno spremljanje kalija v serumu.
English: Common Respiratory infection
Slovenian: Pogosti okužba dihal
English: Anaesthesia and surgery
Slovenian: Anestezija in operacije
English: Hypotension may occur during treatment with Atacand in heart failure patients.
Slovenian: Bolnikom s srčnim popuščanjem se lahko med zdravljenjem z Atacandom pojavi hipotenzija.
English: No initial dose adjustment is necessary for elderly patients or in patients with intravascular volume depletion or renal impairment or mild to moderate hepatic impairment.
Slovenian: Starejšim bolnikom, bolnikom s hipovolemijo, okvaro ledvic ali blago do zmerno okvaro jeter začetnega odmerka ni treba prilagoditi.
English: Both the mortality and morbidity components of these composite endpoints contributed to the favourable effects of candesartan.
Slovenian: K ugodnemu učinku kandesartana sta pripomogla oba elementa te sestavljene končne točke, umrljivost in obolevnost.
English: Therefore, Atacand should be carefully titrated with thorough monitoring of blood pressure in patients on haemodialysis.
Slovenian: Zato je treba bolnikom na hemodializi odmerek Atacanda skrbno prilagajati in jim ob tem natančno kontrolirati krvni tlak.
English: However, in patients with renal impairment, periodic monitoring of serum potassium and creatinine levels is recommended.
Slovenian: Pri bolnikih z okvarjenim delovanjem ledvic pa so priporočljive redne kontrole koncentracije kalija in kreatinina v serumu.
English: Foetotoxicity has been observed in late pregnancy (see section 4.6).
Slovenian: Med pozno brejostjo so opažali fototoksičnost (glejte poglavje 4.6).
English: • Treatment of adult patients with heart failure and impaired left ventricular systolic function (left ventricular ejection fraction ≤ 40%) as add-on therapy to Angiotensin Converting Enzyme (ACE) inhibitors or when ACE inhibitors are not tolerated (see section 5.1).
Slovenian: • zdravljenje odraslih bolnikov s srčnim popuščanjem in okvarjeno sistolično funkcijo levega prekata (iztisni delež levega prekata ≤ 40 %) kot dodatno zdravilo poleg zaviralcev angiotenzinske konvertaze (ACE), ali če bolnik zaviralcev ACE ne prenese (glejte poglavje
English: The usual recommended initial dose of Atacand is 4 mg once daily.
Slovenian: Običajni priporočeni začetni odmerek Atacanda je 4 mg enkrat na dan.
English: Atacand 4, tabletten 4 mg 4 mg
Slovenian: Atacand 4, tabletten 4 mg
English: Atacand 8, tabletten 8 mg 8 mg
Slovenian: Atacand 8, tabletten 8 mg
English: An initial dose of 4 mg once daily is recommended in patients with mild to moderate hepatic impairment.
Slovenian: Pri bolnikih z blago ali zmerno okvaro jeter je priporočljiv začetni odmerek 4 mg enkrat na dan. Odmerek je lahko potrebno prilagoditi glede na odziv.
English: • The usual starting dose of Atacand is 4 mg once a day.
Slovenian: • Običajen začetni odmerek zdravila Atacand je 4 mg enkrat na dan.
English: Heart failure indication
Slovenian: Indikacija srčnega popuščanja
English: The composite endpoint of all-cause mortality or first CHF hospitalisation was also significantly reduced with candesartan, HR 0.87 (95%CI: 0.78 to 0.98, p=0.021).
Slovenian: Sestavljena končna točka umrljivosti zaradi vseh vzrokov ali prve hospitalizacije zaradi kroničnega srčnega popuščanja se je s kandesartanom prav tako značilno zmanjšala, HR 0,87 (95 % IZ: od 0,78 do 0,98, p = 0,021).
English: It is rapidly converted to the active substance, candesartan, by ester hydrolysis during absorption from the gastrointestinal tract.
Slovenian: Med absorpcijo iz prebavil se z estersko hidrolizo hitro spremeni v zdravilno učinkovino, kandesartan.
English: No routine monitoring of laboratory variables is usually necessary for patients receiving Atacand.
Slovenian: Pri bolnikih, ki prejemajo Atacand, po navadi ni treba rutinsko kontrolirati laboratorijskih vrednosti.