FrancophonIA/ELRC3.0 huggingface dataset:
English: Treatment of adult patients with moderate to severe Alzheimer's disease.
Croatian: Liječenje odraslih bolesnika s umjerenom do teškom Alzheimerovom bolešću.
English: Main human metabolites are N-3,5-dimethyl-gludantan, the isomeric mixture of 4- and 6-hydroxymemantine, and 1-nitroso-3,5-dimethyl-adamantane.
Croatian: Glavni metaboliti kod ljudi su N-3,5-dimetil-gludantan, izomerna mješavina 4- i 6-hidroksi-memantina i 1-nitrozo-3,5dimetil-adamantan.
English: On the basis of the clinical studies, the recommended dose for patients over the age of 65 years is 20 mg per day (two 10 mg film-coated tablets or one 20 mg film-coated tablet once a day) as described above.
Croatian: Temeljem kliničkih ispitivanja, preporučena doza za bolesnike starije od 65 godina iznosi 20 mg dnevno (dvije filmom obložene tablete od 10 mg ili jedna filmom obložena tableta od 20 mg jednom dnevno), kao što je gore opisano.
English: From the fourth week on, the usual dose is two tablets once a day (1 x 20 mg).
Croatian: Od četvrtog tjedna nadalje, uobičajena doza je dvije tablete jedanput na dan (1 x 20 mg).
English: In a clinical study in young healthy subjects, no relevant effect of memantine on the pharmacokinetics of galantamine was observed.
Croatian: U kliničkom ispitivanju na mladim zdravim ispitanicima nije uočen značajan učinak memantina na farmakokinetiku galantamina.
English: When daily doses of 5 to 30 mg were administered, a mean cerebrospinal fluid (CSF)/serum ratio of 0.52 was calculated.
Croatian: Pri primjeni dnevnih doza od 5 do 30 mg, izračunat je srednji omjer cerebrospinalni likvor (CSL)/serum od 0,52.
English: - In post-marketing experience, isolated cases with international normalized ratio (INR) increases have been reported in patients concomitantly treated with warfarin.
Croatian: - Nakon stavljanja lijeka u promet, zabilježeni su izolirani slučajevi povišenja internacionalnog normaliziranog omjera (INR-a) kod bolesnika koji su istodobno liječeni varfarinom.
English: Breast-feeding Women taking Marixino should not breast-feed.
Croatian: Dojenje Žene koje uzimaju Marixino ne smiju dojiti.
English: Marixino acts on these NMDA-receptors improving the transmission of nerve signals and the memory.
Croatian: Marixino djeluje na navedene NMDA receptore poboljšavajući prijenos živčanih signala i pamćenje.
English: Marixino film-coated tablets are available in boxes of 14, 28, 30, 42, 50, 56, 60, 70, 84, 90, 98, 100 and 112 film-coated tablets in blisters.
Croatian: Marixino filmom obložene tablete su dostupne u kutijama od 14, 28, 30, 42, 50, 56, 60, 70, 84, 90, 98, 100 i 112 filmom obloženih tableta, u blisterima.
English: At a dose of memantine of 20 mg per day the CSF levels match the ki-value (ki = inhibition constant) of memantine, which is 0.5 μmol in human frontal cortex.
Croatian: Pri dozi od 20 mg memantina dnevno, razine u CSL-u odgovaraju ki-vrijednosti (ki = konstanta inhibicije) memantina, koja u frontalnom korteksu kod ljudi iznosi 0,5 µmol.
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Croatian: Nuspojave možete prijaviti izravno putem nacionalnog sustava za prijavu nuspojava: navedenog u Dodatku V.* Prijavljivanjem nuspojava možete pridonijeti u procjeni sigurnosti ovog lijeka.
English: Concomitant use of N-methyl-D-aspartate (NMDA)-antagonists such as amantadine, ketamine or dextromethorphan should be avoided.
Croatian: Treba izbjegavati istodobnu primjenu antagonista N-metil-D-aspartata (NMDA) kao što su amantadin, ketamin ili dekstrometorfan.
English: Marixino should be administered orally once a day.
Croatian: Marixino treba primjenjivati na usta jedanput na dan.
English: Pharmacokinetic/pharmacodynamic relationship
Croatian: Odnos farmakokinetike/farmakodinamike
English: A meta-analysis of patients with moderate to severe Alzheimer's disease (MMSE total scores < 20) from the six phase III, placebo-controlled, 6-month studies (including monotherapy studies and studies with patients on a stable dose of acetylcholinesterase inhibitors) showed that there was a statistically significant effect in favour of memantine treatment for the cognitive, global, and functional domains.
Croatian: Metaanaliza bolesnika s umjerenom do teškom Alzheimerovom bolešću (ukupni MMSE rezultat <20) iz šest placebom kontroliranih ispitivanja faze III u trajanju od 6 mjeseci (uključujući monoterapijska ispitivanja i ispitivanja s bolesnicima na stabilnoj dozi inhibitora acetilkolinesteraze) pokazala je da postoji statistički značajan učinak u korist liječenja memantinom u kognitivnom, globalnom i funkcionalnom području.
English: Daily doses of 20 mg lead to steady-state plasma concentrations of memantine ranging from 70 to 150 ng/ml (0.5 - 1 μmol) with large interindividual variations.
Croatian: Dnevne doze od 20 mg dovode do plazmatskih koncentracija memantina u stanju dinamičke ravnoteže u rasponu od 70 do 150 ng/ml (0,5 - 1 µmol) s velikim interindividualnim razlikama.
English: The use of medicinal products called amantadine (for the treatment of Parkinson's disease), ketamine (a substance generally used as an anaesthetic), dextromethorphan (generally used to treat cough) and other NMDA-antagonists at the same time should be avoided.
Croatian: Trebalo bi izbjegavati istodobnu primjenu lijekova koji se zovu amantadin (za liječenje Parkinsonove bolesti), ketamin (tvar koja se obično koristi kao anestetik), dekstrometorfan (obično se koristi za liječenje kašlja) i ostalih antagonista NMDA.
English: Marixino is used for the treatment of patients with moderate to severe Alzheimer's disease.
Croatian: Marixino se koristi za liječenje bolesnika s umjerenom do teškom Alzheimerovom bolešću.
English: In clinical trials in mild to severe dementia, involving 1,784 patients treated with memantine and 1,595 patients treated with placebo, the overall incidence rate of adverse reactions with memantine did not differ from those with placebo; the adverse reactions were usually mild to moderate in severity.
Croatian: U kliničkim ispitivanjima blage do teške demencije, u kojima je 1784 bolesnika liječeno memantinom, a 1595 ih je dobivalo placebo, sveukupna stopa incidencije nuspojava u skupini liječenoj memantinom nije se razlikovala od one u skupini koja je primala placebo; nuspojave su uglavnom bile blage do umjerene težine.
English: Maintenance dose The recommended maintenance dose is 20 mg per day.
Croatian: Doza održavanja Preporučena doza održavanja je 20 mg dnevno.
English: Medicinal product subject to restricted prescription (see Annex I: Summary of Product Characteristics, section 4.2).
Croatian: Lijek se izdaje na ograničeni recept (vidjeti Prilog I.: Sažetak opisa svojstava lijeka, dio 4.2).
English: No adverse reactions of memantine were noted on male and female fertility.
Croatian: Nisu zabilježeni štetni učinci memantina na mušku i žensku plodnost.
English: Isolated cases reported in post-marketing experience.
Croatian: Izolirani slučajevi prijavljeni nakon stavljanja lijeka u promet.
English: In the overdose cases below 140 mg or unknown dose the patients revealed symptoms from central nervous system (confusion, drowsiness, somnolence, vertigo, agitation, aggression, hallucination, and gait disturbance) and/or of gastrointestinal origin (vomiting and diarrhoea).
Croatian: U slučajevima predoziranja s dozom manjom od 140 mg ili nepoznatom dozom, bolesnici su opisivali simptome središnjeg živčanog sustava (konfuziju, omamljenost, somnolenciju, vrtoglavicu, agitaciju, agresiju, halucinacije i poremećaj hoda) i/ili gastrointestinalne simptome (povraćanje i proljev).
English: The patient should take two 10 mg film-coated tablets (20 mg) or one 20 mg film-coated tablet per day.
Croatian: Bolesnik treba uzimati dvije filmom obložene tablete od 10 mg (20 mg) ili jednu filmom obloženu tabletu od 20 mg dnevno.
English: You should inform your doctor if you have recently changed or intend to change your diet substantially (e.g. from normal diet to strict vegetarian diet) or if you are suffering from states of renal tubulary acidosis (RTA, an excess of acid-forming substances in the blood due to renal dysfunction (poor kidney function)) or severe infections of the urinary tract (structure that carries urine), as your doctor may need to adjust the dose of your medicine.
Croatian: Ako ste nedavno promijenili ili namjeravate značajno promijeniti svoj način prehrane (npr. s normalne prehrane na strogu vegetarijansku prehranu) ili ako bolujete od stanja renalne tubularne acidoze (RTA - izrazito povećana količina tvari koje tvore kiseline u krvi zbog poremećaja rada bubrega (slaba funkcija bubrega)) ili teških infekcija mokraćnog trakta (struktura kroz koje prolazi mokraća), trebali bi obavijestiti svog liječnika, jer će Vam liječnik možda morati prilagoditi dozu lijeka.
English: What Marixino contains - The active substance is memantine hydrochloride.
Croatian: Što Marixino sadrži - Djelatna tvar je memantinklorid.
English: In volunteers with normal kidney function, total clearance (Cltot) amounts to 170 ml/min/1.73 m2 and part of total renal clearance is achieved by tubular secretion.
Croatian: Kod dobrovoljaca s normalnom funkcijom bubrega, ukupni klirens (Cltot) iznosi do 170 ml/min/1,73 m², te se dio ukupnog bubrežnog klirensa postiže tubularnom sekrecijom.
English: Memantine-treated patients showed a statistically significantly better effect than placebo-treated patients on the primary endpoints: Alzheimer's disease assessment scale (ADAS-cog) (p = 0.003) and CIBIC-plus (p = 0.004) at week 24 (last observation carried forward (LOCF)).
Croatian: Bolesnici liječeni memantinom pokazali su statistički značajno bolji učinak nego bolesnici koji su primali placebo u pogledu primarnih ishoda: skala procjene Alzheimerove bolesti (ADAS-cog) (p=0,003) i CIBIC-plus (p=0,004) u 24. tjednu liječenja (zadnje opažanje preneseno nadalje (LOCF)).
English: In single-dose pharmacokinetic (PK) studies in young healthy subjects, no relevant active substance-active substance interaction of memantine with glyburide/metformin or donepezil was observed.
Croatian: U farmakokinetičkim ispitivanjima (PK) u kojima su primijenjene pojedinačne doze kod mladih zdravih ispitanika nije uočena značajna interakcija djelatna tvar-djelatna tvar između memantina i gliburida/metformina ili donepezila.
English: This is increased to one tablet once a day (1 x 10 mg) in the second week and to 1 and a half tablets once a day (1 x 15 mg) in the third week.
Croatian: Ova doza se povećava na jednu tabletu jedanput na dan (1 x 10 mg) u drugom tjednu, te na jednu i pol tabletu jednom dnevno (1 x 15 mg) u trećem tjednu.
English: In these situations the treatment should be carefully supervised, and the clinical benefit of Marixino reassessed by your doctor on a regular basis.
Croatian: U tim slučajevima liječenje mora biti pažljivo nadzirano, a Vaš liječnik treba redovito ponovno procjenjivati kliničku korist od uzimanja lijeka Marixino.
English: 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 42 film-coated tablets 50 film-coated tablets 56 film-coated tablets 60 film-coated tablets 70 film-coated tablets 84 film-coated tablets 90 film-coated tablets 98 film-coated tablets 100 film-coated tablets 112 film-coated tablets
Croatian: 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 42 filmom obložene tablete 50 filmom obloženih tableta 56 filmom obloženih tableta 60 filmom obloženih tableta 70 filmom obloženih tableta 84 filmom obloženih tableta 90 filmom obloženih tableta 98 filmom obloženih tableta 100 filmom obloženih tableta 112 filmom obloženih tableta
English: Nervous System disorders
Croatian: Poremećaji živčanog sustava
English: The study showed beneficial effects of memantine treatment in comparison to placebo at 6 months (observed cases analysis for the clinician´s interview based impression of change (CIBIC-plus): p = 0.025; Alzheimer's disease cooperative study - activities of daily living (ADCS-ADLsev): p = 0.003; severe impairment battery (SIB): p = 0.002).
Croatian: U 6. mjesecu ispitivanja pokazani su povoljni učinci liječenja memantinom u usporedbi s placebom (analiza opaženih slučajeva za promjene bazirane na dojmu kliničara nakon intervjua (CIBIC-plus): p=0,025; kooperativno ispitivanje Alzheimerove bolesti - aktivnosti svakodnevnog života (ADCS-ADLsev): p=0,003; skup znakova teške onesposobljenosti (SIB): p=0,002).
English: In order to reduce the risk of side effects this dose is achieved gradually by the following daily treatment scheme:
Croatian: Kako bi se smanjio rizik od nuspojava, ta doza se postiže postupno, pridržavajući se sljedeće sheme dnevnog liječenja:
English: When patients were identified with concurrent worsening in all three domains, results showed a statistically significant effect of memantine in preventing worsening, as twice as many placebo-treated patients as memantine-treated patients showed worsening in all three domains (21 % vs. 11 %, p < 0.0001).
Croatian: Kada je ustanovljeno istodobno pogoršanje stanja bolesnika u sva tri područja, rezultati su pokazali statistički značajan učinak memantina u sprječavanju pogoršanja, u skupini bolesnika liječenih placebom bilo je dvostruko više pogoršanja u sva tri područja nego u skupini bolesnika liječenih memantinom (21% naspram 11%, p<0,0001).
English: Not known (frequency cannot be estimated from the available data): - Inflammation of the pancreas, inflammation of the liver (hepatitis) and psychotic reactions
Croatian: Nepoznate učestalosti (učestalost se ne može procijeniti iz raspoloživih podataka): - Upala gušterače, upala jetre (hepatitis) i psihotične reakcije.
English: In order to reduce the risk of side effects this dose is achieved gradually by the following daily treatment scheme.
Croatian: Kako bi se smanjio rizik od nuspojava, ta doza se postiže postupno, pridržavajući se sljedeće sheme dnevnog liječenja.
English: Women taking memantine should not breast-feed.
Croatian: Žene koje uzimaju memantin ne smiju dojiti.
English: No data on the use of memantine in patients with severe hepatic impairment are available.
Croatian: Nisu dostupni podaci o primjeni memantina kod bolesnika s teškim oštećenjem jetre.
English: How to store Marixino
Croatian: Kako čuvati Marixino
English: At the beginning of treatment you will start by using half a 10 mg tablet once a day (1 x 5 mg).
Croatian: Liječenje ćete započeti korištenjem polovice tablete od 10 mg jedanput na dan (1 x 5 mg).
English: Standard clinical procedures to remove active substance material, e.g. gastric lavage, carbo medicinalis (interruption of potential entero-hepatic recirculation), acidification of urine, forced diuresis should be used as appropriate.
Croatian: Treba koristiti standardne kliničke postupke za uklanjanje djelatne tvari, npr. ispiranje želuca, primjenu medicinskog ugljena (prekidanje potencijalne enterohepatičke recirkulacije), zakiseljavanje urina te forsiranu diurezu, kako je prikladno.
English: Dosage in patients with impaired kidney function If you have impaired kidney function, your doctor will decide upon a dose that suits your condition.
Croatian: Ako imate oštećenu funkciju bubrega, liječnik će odlučiti o dozi koja odgovara Vašem stanju.
English: The recommended dose of Marixino for adults and older people is 20 mg once a day.
Croatian: Preporučena doza lijeka Marixino za odrasle i starije osobe je 20 mg jednom dnevno.
English: In man, about 80 % of the circulating memantine-related material is present as the parent compound.
Croatian: Kod ljudi je oko 80% memantina u cirkulaciji prisutno u nepromijenjenom obliku.
English: Pregnancy The use of memantine in pregnant women is not recommended.
Croatian: Trudnicama se ne preporučuje upotreba memantina.
English: In patients with severe renal impairment (creatinine clearance 5 - 29 ml/min) daily dose should be 10 mg per day.
Croatian: Kod bolesnika s teškim oštećenjem bubrega (klirens kreatinina 5 - 29 ml/min) dnevna doza bi trebala biti 10 mg dnevno.
English: In patients with mildly impaired renal function (creatinine clearance 50 - 80 ml/min) no dose adjustment is required.
Croatian: Kod bolesnika s blagim oštećenjem funkcije bubrega (klirens kreatinina 50 - 80 ml/min) nije potrebna prilagodba doze.
English: In patients with moderate renal impairment (creatinine clearance 30 - 49 ml/min) daily dose should be 10 mg per day.
Croatian: Kod bolesnika s umjerenim oštećenjem bubrega (klirens kreatinina 30 - 49 ml/min), dnevna doza bi trebala biti 10 mg na dan.
English: If you take more Marixino than you should - In general, taking too much Marixino should not result in any harm to you.
Croatian: - Općenito, uzimanje previše lijeka Marixino ne bi Vam trebalo naškoditi.
English: There are no or limited amount of data from the use of memantine in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni memantina u trudnica ograničeni.
English: Dosage The recommended dose of Marixino for adults and older people is 20 mg once a day.
Croatian: Doziranje Preporučena doza lijeka Marixino za odrasle i starije osobe je 20 mg jednom dnevno.
English: Only limited experience with overdose is available from clinical studies and post-marketing experience.
Croatian: Iz kliničkih ispitivanja i nakon stavljanja lijeka u promet dostupno je samo ograničeno iskustvo u vezi s predoziranjem.
English: Very rare
Croatian: Vrlo rijetko napadaji
English: In another monotherapy study in mild to moderate Alzheimer's disease a total of 470 patients (MMSE total scores at baseline of 11 - 23) were randomised.
Croatian: U drugom monoterapijskom ispitivanju blage do umjerene Alzheimerove bolesti randomizirano je ukupno 470 bolesnika (početne vrijednosti ukupnog MMSE od 11-23).
English: Psychotic reactions
Croatian: Nepoznato psihotične reakcije
English: Marixino 10 mg film-coated tablets Each film-coated tablet contains 51.45 mg lactose monohydrate.
Croatian: Marixino 10 mg filmom obložene tablete Svaka filmom obložena tableta sadrži 51,45 mg laktoze hidrata.
English: Each film-coated tablet contains 10 mg memantine hydrochloride equivalent to 8.31 mg memantine.
Croatian: Svaka filmom obložena tableta sadrži 10 mg memantinklorida, što odgovara 8,31 mg memantina.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar pojedine skupine učestalosti nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
English: • Periodic Safety Update Reports
Croatian: • Periodička izvješća o neškodljivosti lijeka
English: The usual starting dose is half a tablet once a day (1 x 5 mg) for the first week.
Croatian: Uobičajena početna doza iznosi pola tablete jedanput na dan (1 x 5 mg) tijekom prvog tjedna.
English: A pivotal monotherapy study in a population of patients suffering from moderate to severe Alzheimer's disease (mini mental state examination (MMSE) total scores at baseline of 3 - 14) included a total of 252 outpatients.
Croatian: Pivotalno ispitivanje monoterapije u populaciji bolesnika koji pate od umjerene do teške Alzheimerove bolesti (početne vrijednosti kratkog testa određivanja mentalnog statusa (MMSE) bile su 3-14) uključivalo je ukupno 252 ambulantna bolesnika.
English: Marixino 20 mg film-coated tablets Each film-coated tablet contains 102.90 mg lactose monohydrate.
Croatian: Marixino 20 mg filmom obložene tablete Svaka filmom obložena tableta sadrži 102,90 mg laktoze hidrata.
English: The following Adverse Reactions listed in the table below have been accumulated in clinical studies with memantine and since its introduction in the market.
Croatian: Sljedeće nuspojave koje su prikupljene tijekom kliničkih ispitivanja s memantinom i nakon stavljanja lijeka u promet su prikazane u tablici ispod.
English: Memantine is a voltage-dependent, moderate-affinity uncompetitive NMDA-receptor antagonist.
Croatian: Memantin je nekompetitivni antagonist NMDA-receptora, umjerenog afiniteta i ovisan o naponu.
English: Marixino contains the active substance memantine hydrochloride.
Croatian: Marixino sadrži djelatnu tvar memantinklorid.
English: Administration of Marixino is not recommended in patients with severe hepatic impairment.
Croatian: Ne preporučuje se primjena lijeka Marixino kod bolesnika s teškim oštećenjem jetre.
English: Each film-coated tablet contains 20 mg memantine hydrochloride equivalent to 16.62 mg memantine.
Croatian: Svaka filmom obložena tableta sadržava 20 mg memantinklorida što odgovara 16,62 mg memantina.
English: Week 3 (day 15-21) The patient should take one and a half 10 mg film-coated tablets (15 mg) per day for 7 days.
Croatian: 3. tjedan (15-21. dan) Bolesnik treba uzimati jednu i pol filmom obloženu tabletu od 10 mg (15 mg) dnevno tijekom 7 dana.
English: Tablet core: lactose monohydrate, microcrystalline cellulose (E460), anhydrous colloidal silica, talc (E553b), magnesium stearate (E470b).
Croatian: Jezgra tablete: laktoza hidrat, mikrokristalična celuloza (E460), koloidni bezvodni silicijev dioksid, talk (E553b), magnezijev stearat (E470b).
English: Film coating: methacrylic acid-ethyl acrylate copolymer (1:1), sodium laurilsulfate, polysorbate 80, talc (E553b), triacetin, simeticone.
Croatian: Film ovojnica: metakrilatna kiselina/etilakrilat kopolimer (1:1), natrijev laurilsulfat, polisorbat 80, talk (E553b), triacetin, simetikon.
English: Week 2 (day 8-14) The patient should take one 10 mg film-coated tablet (10 mg) per day for 7 days.
Croatian: 2. tjedan (8-14. dan) Bolesnik treba uzimati jednu filmom obloženu tabletu od 10 mg (10 mg) dnevno tijekom 7 dana.
English: Uncommon (may affect up to 1 in 100 people): - Tiredness, fungal infections, confusion, hallucinations, vomiting, abnormal gait, heart failure and venous blood clotting (thrombosis/thromboembolism).
Croatian: Manje česte (mogu se javiti u manje od 1 na 100 osoba): - Umor, gljivične infekcije, smetenost, halucinacije, povraćanje, poremećaj hoda, zatajenje srca i zgrušavanje venske krvi (tromboza/tromboembolija).
English: Week 1 (day 1-7) The patient should take half a 10 mg film-coated tablet (5 mg) per day for 7 days.
Croatian: 1. tjedan (1-7. dan) Bolesnik treba uzimati polovicu filmom obložene tablete od 10 mg (5 mg) dnevno tijekom 7 dana.
English: In post-marketing experience these reactions have been reported in patients treated with memantine.
Croatian: Ove su nuspojave prijavljene nakon stavljanja lijeka u promet kod bolesnika liječenih memantinom.
English: - There may be a possibility of reduced serum level of hydrochlorothiazide (HCT) when memantine is co-administered with HCT or any combination with HCT.
Croatian: - Pri istodobnoj primjeni memantina i hidroklorotiazida (HCT-a) ili bilo koje od kombinacija s HCT-om, postoji mogućnost smanjenja koncentracije HCT-a u serumu.
English: Two 10 mg tablets
Croatian: Dvije tablete od 10 mg
English: One and a half 10 mg tablets
Croatian: Jedna i pol tableta od 10 mg
English: Gait abnormal
Croatian: Manje često abnormalni hod
English: White, oval, biconvex film-coated tablet, scored on one side (tablet length: 12.2-12.9 mm, thickness: 3.5-4.5 mm).
Croatian: Bijela, ovalna, bikonveksna filmom obložena tableta, s razdjelnom crtom na jednoj strani (dužina tablete: 12,2-12,9 mm, debljina: 3,5-4,5 mm).
English: One 10 mg tablet
Croatian: Jedna tableta od 10 mg
English: Lactose monohydrate Cellulose, microcrystalline (E460) Silica, colloidal anhydrous Talc (E553b)
Croatian: Jezgra tablete laktoza hidrat celuloza, mikrokristalična (E460) silicijev dioksid, koloidni, bezvodni talk (E553b) magnezijev stearat (E470b)
English: Marixino 10 mg film-coated tablets Marixino 20 mg film-coated tablets
Croatian: Marixino 10 mg filmom obložene tablete Marixino 20 mg filmom obložene tablete
English: Common (may affect up to 1 in 10 people): - Headache, sleepiness, constipation, elevated liver function test, dizziness, balance disorders,
Croatian: Česte (mogu se javiti u manje od 1 na 10 osoba): - Glavobolja, pospanost, zatvor, povišeni rezultati testova jetrene funkcije, omaglica, poremećaji ravnoteže, nedostatak zraka, visoki krvni tlak i preosjetljivost na lijek.