FrancophonIA/ELRC3.0 huggingface dataset:
English: • severe skin reactions
Danish: • alvorlige hudreaktioner
English: Such problems might be due to a bone disease called ‘osteonecrosis' (loss of blood supply to the bone causing bone death), which can occur months to years after starting HIV therapy.
Danish: Sådanne problemer kan skyldes en knoglesygdom kaldet ”ostenekrose” (knogledød på grund af manglende blodtilførsel til knoglerne), som kan forekomme to år efter påbegyndelse af hiv-behandling.
English: Indinavir alone or in combination with nucleoside analogues (zidovudine/stavudine and lamivudine) has been shown to delay clinical progression rate compared with nucleoside analogues and to provide a sustained effect on viral load and CD4 count.
Danish: Indinavir alene eller i kombination med nukleosidanaloger (zidovudin/stavudin og lamivudin) har vist at forsinke den kliniske progressionsrate sammenlignet med nukleosidanaloger og yder en vedvarende effekt på viralmængden og CD4-tallet.
English: In some patients, resolution of the interstitial nephritis did not occur following discontinuation of indinavir therapy; renal insufficiency, renal failure, leucocyturia (see section 4.4).
Danish: Hos nogle patienter svandt den interstitielle nefritis ikke ved seponering af behandling med indinavir; nyreinsufficiens, nyresvigt, leukocyturi (se pkt.
English: 3; and the mean increase in percent CD4 cell counts was 4.2 %.
Danish: 3, og middelstigningen af CD4-celletal var, angivet i procent, 4,2 %.
English: • itraconazole, ketoconazole - used to treat fungal infections
Danish: • itraconazol, ketoconazol - anvendes til behandling af svampeinfektioner
English: Synergistic antiretroviral activity was observed when human T-lymphoid cells infected with the LAI variant of HIV-1 were incubated with indinavir and either zidovudine, didanosine, or NNRTIs.
Danish: Der sås synergistisk antiretroviral aktivitet, når humane T-lymfeceller inficerede med LAI varianten af hiv-1 blev inkuberet med indinavir og enten zidovudin, didanosin eller en non-nukleosid revers transcriptasehæmmer.
English: HIV 1 patient isolates with reduced susceptibility to indinavir expressed varying patterns and degrees of cross-resistance to a series of diverse HIV PIs, including ritonavir and saquinavir.
Danish: Isolater fra hiv-1 patienter med nedsat følsomhed overfor indinavir udviste varierende mønstre og grader af krydsresistens overfor serier af forskellige hiv-proteasehæmmere, inklusive ritonavir og saquinavir.
English: Dose reduction of CRIXIVAN to 400-600 mg every 8 hours should be considered.
Danish: Dosisreduktion af CRIXIVAN til 400-600 mg hver 8. time bør overvejes.
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Danish: Hos hiv-inficerede patienter med svær immundefekt kan der ved påbegyndelse af antiretroviral kombinationsbehandling (CART) opstå en inflammatorisk reaktion på asymptomatiske eller residuale opportunistiske infektioner.
English: If CRIXIVAN is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Danish: Hvis CRIXIVAN administreres samtidigt med parenteral midazolam, bør det gøres på en intensivafdeling med tæt klinisk monitorering i tilfælde af respirationsdepression og/eller forlænget sedering.
English: Talk to your doctor, pharmacist or nurse before taking CRIXIVAN if you have had or develop any of the following:
Danish: Kontakt lægen, apotekspersonalet eller sundhedspersonalet, før De tager CRIXIVAN, hvis De har haft eller får noget af følgende:
English:  dihydropyridine calcium channel blocker concentration
Danish:  dihydropyridin calciumantagonistkoncentration
English: Patients with severe hepatic impairment have not been studied; therefore, no dosing recommendations can be made (see section 4.4).
Danish: Patienter med alvorligt nedsat leverfunktion er ikke undersøgt; derfor kan der ikke gives doseringsvejledning til disse patienter (se pkt.
English: If you stop taking CRIXIVAN
Danish: Hvis De holder op med at tage CRIXIVAN
English: For information regarding diet or the effect of food on indinavir absorption (see sections 4.2 and 5.2).
Danish: For information om effekt af diæt eller mad på indinavirabsorption (se pkt.
English: At week 4, the indinavir Cmin was 500 ng/mL with substantial trough variability (range 5 to 8,100 ng/mL).
Danish: Ved uge 4 var indinavirs Cmin 500 ng/ml med væsentlig variabilitet i minimumsværdien (5-8100
English:  indinavir plasma concentrations may be expected (CYP3A induction).
Danish:  indinavirs plasmakoncentrationer kan forventes (CYP3A-induktion).
English: • liver problems - people with ‘chronic hepatitis B or C' or ‘cirrhosis' who are treated with ‘antiretroviral' medicines are more likely to have serious and potentially fatal liver side effects with this medicine.
Danish: • leverproblemer - patienter med kronisk hepatitis B eller C eller cirrose, der bliver behandlet med antiretrovirale lægemidler, har større risiko for at få alvorlige og potentielt livsfarlige leverpåvirkninger med dette lægemiddel.
English: Metabolism of pravastatin and fluvastatin is not dependent on CYP3A4.
Danish: Pravastatins og fluvastatins metabolisme er ikke afhængig af CYP3A4.
English: Indinavir is rapidly absorbed in the fasted state with a time to peak plasma concentration of 0.8 hours ± 0.3 hours (mean ± S.D.).
Danish: Indinavir absorberes hurtigt i fastende tilstand med 0,8 times varighed ± 0,3 time (middelværdi ± S.D.) til maksimalt plasmaniveau nås.
English: ANTICONVULSANTS Carbamazepine, phenobarbital phenytoin
Danish: ANTIKONVULSIVA Carbamazepin, phenobarbital phenytoin
English: Amprenavir 600 mg BID AUC ↑ 64 % with 100 mg BID ritonavir alone (relative to amprenavir 1,200 mg BID alone).
Danish: Amprenavir 600 mg BID AUC ↑ 64 % med 100 mg BID ritonavir alene (i forhold til amprenavir 1200 mg BID alene).
English: Due to CYP3A inhibition by indinavir, concentrations of quetiapine are expected to increase.
Danish: På grund af indinavirs hæmning af CYP3A forventes koncentrationen af quetiapin at stige.
English: Haemophiliac patients should therefore be made aware of the possibility of increased bleeding.
Danish: Patienter med hæmofili bør gøres opmærksom på risikoen for øget blødningstendens.
English: Amprenavir 1,200 mg BID AUC ↑90 % with 800 mg TID indinavir alone (see Table 1).
Danish: Amprenavir 1200 mg BID AUC ↑ 90 % med 800 mg TID indinavir alene (se tabel 1).
English: There are no data to suggest that indinavir affects the ability to drive and use machines.
Danish: Der er ingen data, der viser, at indinavir påvirker evnen til at køre bil og anvende maskiner.
English: liver function abnormalities
Danish: Abnorm leverfunktion
English: Boosted indinavir (indinavir with ritonavir) may have additive pharmacokinetic effects on substances that share the CYP3A4 pathway as both ritonavir and indinavir inhibit the cytochrome P450 enzyme CYP3A4.
Danish: Boostet indinavir (indinavir med ritonavir) kan have additiv farmakokinetisk effekt på substanser, som metaboliseres ad samme vej som CYP3A4, da både ritonavir og indinavir hæmmer cytochrom P450 enzymet, CYP3A4.
English: What CRIXIVAN is
Danish: Hvad er CRIXIVAN
English: What you need to know before you take CRIXIVAN
Danish: Det skal De vide, før De begynder at tage CRIXIVAN
English: The interaction of indinavir or indinavir/ritonavir with pravastatin or fluvastatin is not known (see section 4.5).
Danish: Indinavirs eller indinavir/ritonavirs interaktion med pravastatin eller fluvastatin er ukendt (se pkt.
English: Medicinal product resistance
Danish: Lægemiddelresistens
English: Taking this medicine
Danish: Sådan skal De tage medicinen
English: Excipient with known effect Each 400 mg capsule contains 149.6 mg of lactose.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver 400 mg kapsel indeholder 149,6 mg lactose.
English: • fluconazole - used for fungal infections
Danish: • fluconazol - anvendes mod svampeinfektioner
English: Medicinal products interactions
Danish: Lægemiddelinteraktioner
English: ANALGESICS Fentanyl
Danish: ANALGETIKA Fentanyl
English: • An example of another medicine that might be given to you, at the same time as CRIXIVAN,
Danish: • Et eksempel på et andet lægemiddel, De kan få sammen med CRIXIVAN, er ritonavir.
English: HMG-CoA REDUCTASE INHIBITORS Lovastatin, simvastatin
Danish: HMG-Co- REDUKTASEHÆMMERE Lovastatin, simvastatin
English: CRIXIVAN is indicated in combination with antiretroviral nucleoside analogues for the treatment of HIV-1 infected adults.
Danish: CRIXIVAN er i kombination med antiretrovirale nukleosidanaloger indiceret til behandling af voksne med hiv-1 infektion.
English: If you forget to take CRIXIVAN
Danish: Hvis De har glemt at tage CRIXIVAN
English: Dizziness and blurred vision have been reported during treatment with CRIXIVAN.
Danish: Der er indberettet svimmelhed og sløret syn under behandling med CRIXIVAN.
English: Norethindrone AUC: ↑ 26 % Norethindrone Cmin: ↑ 44 %
Danish: Norethindron AUC: ↑ 26 % Norethindron Cmin: ↑ 44 %
English: • dry mouth
Danish: • tør mund
English: Indinavir AUC:  92 % (Relative to Indinavir 800 mg TID alone) This effect is due to an induction of CYP3A4 by rifampicin.
Danish: Indinavir AUC:  92 % (I forhold til indinavir 800 mg TID alene) Denne effekt skyldes rifampicins induktion af CYP3A4.
English: ANTI-INFECTIVES Antiretrovirals NRTIs
Danish: ANTI-INFEKTIVA Antiretrovirale lægemidler NRTIer
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Danish: Patienter med kronisk hepatitis B eller C, og som har modtaget antiretroviral kombinationsbehandling, har øget risiko for at få alvorlige og potentielt fatale leverbivirkninger.
English: This could be dry toast with jam or cornflakes with skimmed or low-fat milk and sugar.
Danish: For eksempel ristet brød med marmelade eller cornflakes med mælk med lavt fedtindhold og sukker.
English: Dose modification of calcium channel blockers should be considered when coadministered with indinavir/ritonavir as it may result in an increased response.
Danish: Dosismodificering af calciumantagonister bør overvejes, når de administreres samtidigt med indinavir/ritonavir, da det kan medføre øget respons.
English: Caution should be used with coadministration of CRIXIVAN and parenteral midazolam.
Danish: Forsigtighed bør udvises ved samtidig administration af CRIXIVAN og parenteral midazolam.
English: Patients with mild-to-moderate hepatic insufficiency due to cirrhosis will require a dose reduction of indinavir due to decreased metabolism of indinavir (see section 4.2).
Danish: Hos patienter med mild til moderat leverinsufficiens på grund af cirrose vil det være nødvendigt at reducere indinavirdosis på grund af nedsat metabolisme af indinavir (se pkt.
English: Isolated asymptomatic hyperbilirubinaemia (total bilirubin  2.5 mg/dL, 43 mcmol/L) was reported predominantly as elevated indirect bilirubin and rarely associated with elevations in ALT, AST, or alkaline phosphatase, has occurred in approximately 14 % of patients treated with CRIXIVAN alone or in combination with other antiretroviral agents.
Danish: Der er rapporteret om isoleret asymptomatisk hyperbilirubinæmi (totalbilirubin ≥2,5 mg/dl, 43 µmol/l) overvejende som forhøjet indirekte bilirubin og sjældent forbundet med stigning i ALAT, ASAT eller alkalisk fosfatase hos ca. 14 % af de patienter, der blev behandlet med CRIXIVAN alene eller i kombination med andre antiretrovirale lægemidler.
English: Anti-Mycobacterial Rifabutin
Danish: Antimykobakterielle lægemidler Rifabutin
English: Excipient with known effect Each 200 mg capsule contains 74.8 mg lactose.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver 200 mg kapsel indeholder 74,8 mg lactose.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Danish: Autoimmune lidelser (såsom Graves' sygdom og autoimmun hepatitis) er også set; tiden til udbrud er mere variabel og kan være mange måneder efter initiering af behandling (se pkt.
English: In one published study, 20 HIV-infected patients with undetectable plasma viral load (< 200 copies/mL) receiving indinavir 800 mg every 8 hours were switched in an open, cross-over design to indinavir/ritonavir 400/100 mg every 12 hours.
Danish: I en publiceret undersøgelse blev 20 hiv-inficerede patienter med upåviselig virusbelastning i plasma (< 200 kopier/ml), og som fik indinavir 800 mg hver 8. time, skiftet over til indinavir/ritonavir 400/100 mg hver 12. time i et åbent, cross-over design.
English: Concomitant use of indinavir with lovastatin or simvastatin is not recommended due to an increased risk of myopathy including rhabdomyolysis.
Danish: Samtidig brug af indinavir og lovastatin eller simvastatin anbefales ikke på grund af en øget risiko for myopati omfattende rhabdomyolyse.
English: ANTI-INFECTIVES Antiretrovirals Amprenavir
Danish: ANTI-INFEKTIVA Antiretrovirale lægemidler Amprenavir
English: Stavudine AUC: ↑ 21 % Stavudine Cmin: not evaluated
Danish: Stavudin AUC: ↑ 21 % Stavudin Cmin: ikke evalueret
English: Based on an interaction study with lopinavir/ritonavir, combination of rosuvastatin and protease inhibitors is not recommended.
Danish: Baseret på en interaktionsundersøgelse med lopanavir/ritonavir anbefales kombinationen af rosuvastatin og proteasehæmmere ikke.
English: Indinavir AUC:  28 % (Relative to Indinavir 800 mg SD alone) Venlafaxine and active metabolite Odesmethyl-venlafaxine: 
Danish: Indinavir AUC:  28 % (I forhold til indinavir 800 mg SD alene) Venlafaxin og den aktive metabolit Odesmethyl-venlafaxin: 
English: CRIXIVAN contains lactose
Danish: CRIXIVAN indeholder lactose
English: ORAL CONTRACEPTIVES Norethindrone/ethinyl estradiol 1/35 1 mcg QD (Indinavir 800 mg TID)
Danish: ORALE KONTRACEPTIVA Norethindron/ethinylestradiol 1/35 1 mcg QD (Indinavir 800 mg TID)
English: If co-administered with ritonavir, CRIXIVAN may be administered with or without food
Danish: Hvis CRIXIVAN administreres sammen med ritonavir, kan det administreres med eller uden mad.
English: Marketing Authorisation Holder: Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, The Netherlands
Danish: Indehaver af markedsføringstilladelsen: Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, Holland.
English: Cyclosporine A dose adjustments should be made according to measured cyclosporine A trough blood levels.
Danish: Dosisjustering af ciclosporin bør foretages i henhold til den lavest målte ciclosporin koncentration i blodet.
English: No data has been obtained comparing rifabutin 150 mg QD in combination with indinavir 800 mg TID with a reference dose of 150 mg rifabutin alone)
Danish: sammenligning af rifabutin 150 mg QD sammen med indinavir 800 mg TID og en referencedosis på 150 mg rifabutin alene)
English: If CRIXIVAN with ritonavir is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Danish: Hvis CRIXIVAN og ritonavir administreres samtidigt med parenteral midazolam, bør det gøres på en intensivafdeling med tæt klinisk monitorering i tilfælde af respirationsdepression og/eller forlænget sedering.
English: (Relative to Indinavir 800 mg TID alone)
Danish: (I forhold til indinavir 800 mg TID alene)
English: By intent to treat analysis 65 % of patients had HIV RNA < 400 copies/mL and 50 % had viral load < 50 copies/mL; by on-treatment analysis 96 % of patients had HIV RNA < 400 copies/mL and 74 % had viral load < 50 copies/mL.
Danish: Ved analyse af intent-to-treat havde 65 % af patienterne hiv RNA <400 kopier/ml, og 50 % havde en virusbelastning på < 50 kopier/ml; ved analyse af on-treatment havde 96 % af disse hiv RNA < 400 kopier/ml, og 74 % havde en virusbelastning på < 50 kopier/ml.
English: • quetiapine - used for some mental illnesses such as schizophrenia, bipolar disorder and major depressive disorder
Danish: • quetiapin - anvendes til visse sindslidelser, fx skizofreni, bipolare affektive sindslidelser
English: Indinavir at concentrations of 50 to 100 nM mediated 95 % inhibition (IC95) of viral spread (relative to an untreated virus-infected control) in human T-lymphoid cell cultures and primary human monocytes/macrophages infected with HIV 1 variants LAI, MN, RF, and a macrophage-tropic variant SF-162, respectively.
Danish: Indinavir medierede i koncentrationer på 50-100 nM 95 % hæmning (IC95) af viral spredning (i forhold til en ubehandlet virusinficeret kontrol) i humane T-lymfocytcellekulturer og primære humane monocytter/makrofager inficeret med henholdsvis hiv-1 varianterne LAI, MN, RF og en makrofagtrofisk variant SF-162.
English: Safety in patients with impaired renal function has not been studied; however, less than 20 % of indinavir is excreted in the urine as unchanged medicinal product or metabolites (see section 4.2).
Danish: Sikkerhed hos patienter med nedsat nyrefunktion er ikke undersøgt; mindre end 20 % af indinavir udskilles imidlertid i urinen som uomdannet lægemiddel eller metabolitter (se pkt.
English: The metabolism of indinavir is mediated by the cytochrome P450 enzyme CYP3A4.
Danish: Indinavirs metabolisme er medieret af cytokrom P450-enzymet CYP3A4.
English: Interaction with indinavir/ritonavir not studied R-warfarin levels may be decreased leading to reduced anticoagulation due to induction of CYP1A2 and CYP2C9 by ritonavir.
Danish: R-warfarinkoncentrationen kan falde, hvilket fører til reduceret antikoagulation på grund af ritonavirs induktion af CYP1A2 og CYP2C9.
English: • Do not crush or chew the capsules.
Danish: • Kapslerne må ikke knuses eller tygges.
English: Similarly, in antiretroviral naive patients, indinavir with and without zidovudine compared with zidovudine alone reduced the probability of ADID at 48 weeks from 15 % with zidovudine alone to approximately 6 % with indinavir alone or in combination with zidovudine.
Danish: Hos antiretroviralt naive patienter, reducerede indinavir ligeledes, med og uden zidovudin, sandsynligheden for ADID efter 48 uger fra 15 % med zidovudin alene til ca. 6 % med indinavir alene eller i kombination med zidovudin.
English: Indinavir and norethindrone/ethinyl estradiol 1/35 can be coadministered without dose adjustment.
Danish: Indinavir og norethindron/ethinylestradiol 1/35 kan administreres samtidigt uden dosisjustering.
English: Caution is warranted and therapeutic concentration monitoring is recommended for quinidine when coadministered with CRIXIVAN.
Danish: Forsigtighed tilrådes og monitorering af den terapeutiske koncentration anbefales for quinidin, når dette administreres sammen med CRIXIVAN.
English: The inducing effect may persist up to 2 weeks after cessation of treatment with St. John's wort.
Danish: Den inducerende virkning kan vare i op til 2 uger efter seponering af behandling med perikon.
English: CALCIUM CHANNEL BLOCKERS Dihydropyridine: e.g., felodipine, nifedipine, nicardipine
Danish: CALCIUMANTAGONISTER Dihydropyridin: fx felodipin, nifedipin, nicardipin
English: The most commonly reported symptoms were gastro-intestinal (e.g., nausea, vomiting, diarrhoea) and renal (e.g., nephrolithiasis, flank pain, haematuria).
Danish: De hyppigst rapporterede symptomer var gastrointestinale (fx kvalme, opkastning, diarré) og renale (fx nefrolitiasis, lændesmerter, hæmaturi).
English: Safety in patients with impaired renal function has not been studied; however, less than 20 % of indinavir is excreted in the urine as unchanged medicinal product or metabolites (see section 4.4).
Danish: Sikkerhed hos patienter med nedsat nyrefunktion er ikke undersøgt; mindre end 20% af indinavir udskilles imidlertid i urinen som uomdannet lægemiddel eller metabolitter (se pkt.
English: • allergic reactions - signs include itchy skin, redness of the skin, ‘wheals' or ‘hives', swelling of the face, lips, tongue or throat and difficulty breathing.
Danish: • allergiske reaktioner - fx følgende symptomer: hudkløe, hudrødme, blærer eller nældefeber, hævelse af ansigt, læber, tunge eller svælg samt vejrtrækningsbesvær.
English: The bottles contain desiccant canisters that should remain in the container.
Danish: Beholderen indeholder et fugtabsorberende middel som bør forblive i beholderen.
English: Rifabutin AUC*: ↑ 54 % Rifabutin Cmin*: ↑ 99 % (*Relative to rifabutin 300 mg QD alone.
Danish: Rifabutin AUC*: ↑ 54 % Rifabutin Cmin*: ↑ 99 % (*I forhold til rifabutin 300 mg QD alene.
English: Indinavir:  (Relative to Indinavir 800 mg SD alone) Didanosine: 
Danish: Indinavir:  (I forhold til indinavir 800 mg SD alene) Didanosin: 
English: In HIV-infected paediatric patients, the pharmacokinetic parameters of indinavir in apple sauce were: AUC0-8hr of 26,980 nM*h; peak plasma concentration of 13,711 nM; and plasma concentration at 8 hours post dose of 146 nM.
Danish: I hiv-inficerede pædiatriske patienter var indinavirs farmakokinetiske parametre i æblemos: AUC0-8 timer på 26980 nM*t; maksimal plasmakoncentration på 13711 nM og plasmakoncentration på 146 nM 8 timer efter dosering.
English: No studies on the effects on the ability to drive and use machines have been performed.
Danish: Der er ikke udført studier af indvirkningen på evnen til at føre motorkøretøj og betjene maskiner.
English: Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered.
Danish: Dosisreduktion af CRIXIVAN til 600 mg hver 8. time bør overvejes.
English: Indinavir AUC and Cmin: ↔ (Relative to Indinavir 400 mg SD)  Quinidine concentration expected (CYP3A4 inhibition by indinavir)
Danish: Indinavir AUC og Cmin: ↔ (I forhold til indinavir 400 mg SD)  Quinidinkoncentration forventelig (indinavirs CYP3A4-hæmning)
English: Capsule content anhydrous lactose magnesium stearate
Danish: Kapselindhold: lactose, vandfri magnesiumstearat
English: Preliminary clinical data suggest that CRIXIVAN 400 mg in combination with ritonavir 100 mg, both administered orally twice daily, may be an alternative dosing regimen (see section 5.2).
Danish: Præliminære kliniske data antyder, at CRIXIVAN 400 mg i kombination med ritonavir 100 mg, når begge administreres peroralt to gange dagligt, kan være et alternativt dosisregimen (se pkt.
English: When indinavir is administered as monotherapy resistant viruses rapidly emerge (see section 5.1).
Danish: Når indinavir administreres som monoterapi, dannes hurtigt resistent virus (se pkt.
English: • rash or dry skin
Danish: • udslæt eller tør hud
English: increases in MCV, decreases in neutrophils increased spontaneous bleeding in patients with haemophilia, anemia including acute haemolytic anaemia, thrombocytopenia (see section 4.4).
Danish: Øget antal spontane blødninger hos patienter med hæmofili, anæmi inklusive akut hæmolytisk anæmi; trombocytopeni (se pkt.
English: Indinavir inhibits CYP3A4 and as a result is expected to markedly increase the plasma concentrations of these HMG-CoA reductase inhibitors, which are highly dependent on CYP3A4 metabolism.
Danish: Indinavir hæmmer CYP3A4 og forventes derfor at øge plasmakoncentrationen af de HMG-CoA-reduktasehæmmere markant, som er yderst afhængige af CYP3A4metabolismen.
English: With the exception of dry skin, rash, and taste perversion, the incidence of clinical adverse reactions was similar or higher among patients treated with antiretroviral nucleoside analogue controls than among patients treated with CRIXIVAN monotherapy or in combination with NRTI(s).
Danish: Med undtagelse af tør hud, udslæt og smagsforstyrrelser var forekomsten af bivirkninger den samme eller højere hos patienter i antiretroviral nukleosidanalogkontrolgruppen end hos patienter behandlet med CRIXIVAN alene eller i kombination med NRTI.
English: Manufacturer: Merck Sharp & Dohme B.V., Waarderweg 39, Postbus 581, 2003 PC Haarlem The Netherlands
Danish: Fremstiller: Merck Sharp & Dohme B.V., Waarderweg 39, Postbus 581, 2003 PC Haarlem, Holland.