FrancophonIA/ELRC3.0 huggingface dataset:
English: The primary mode of action of voriconazole is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis.
Croatian: Primarni je način djelovanja vorikonazola inhibicija gljivičnim citokromom P450 posredovane demetilacije 14-alfa-lanosterola, što predstavlja ključni korak u biosintezi gljivičnog ergosterola.
English: In case of use as prophylaxis, refer below.
Croatian: U slučaju primjene kao profilakse, pogledajte u nastavku.
English: There have been reports of prolonged visual adverse reactions, including blurred vision, optic neuritis and papilloedema (see section 4.8).
Croatian: Prijavljeni su slučajevi produljenih nuspojava vida koje uključuju zamagljen vid, optički neuritis i papiloedem (vidjeti dio 4.8)
English: What Voriconazole Hikma is and what it is used for
Croatian: Što je Vorikonazol Hikma i za što se koristi
English: Fifty-three paediatric patients aged 2 to <18 years were treated with voriconazole in two prospective, openlabel, non-comparative, multi-center clinical trials.
Croatian: Vorikonazolom je liječeno 53 pedijatrijskih bolesnika u dobi od 2 do <18 godina u dva prospektivna, otvorena, nekomparativna, multicentrična klinička ispitivanja.
English: The effects on parturition are probably mediated by species-specific mechanisms, involving reduction of oestradiol levels, and are consistent with those observed with other azole antifungal agents.
Croatian: Ovi učinci na okot vjerojatno su posredovani mehanizmima specifičnima za pojedinu vrstu koji uključuju smanjenje razina estradiola i odgovaraju učincima ostalih azolskih antimikotika.
English: When the Voriconazole Hikma infusion is complete, the line may be used for administration of other intravenous products.
Croatian: Kada se dovrši infuzija lijeka Vorikonazol Hikma, ista se linija može upotrijebiti za primjenu drugih intravenskih lijekova.
English: The ERG changes did not progress over 29 days of treatment and were fully reversible on withdrawal of voriconazole.
Croatian: Promjene na ERG-u nisu se pogoršavale tijekom 29 dana primjene lijeka i u cijelosti su se povukle nakon prestanka primjene vorikonazola.
English: Contact your doctor immediately if you become pregnant while being treated with Voriconazole Hikma.
Croatian: Odmah se javite svom liječniku ako zatrudnite za vrijeme liječenja lijekom Vorikonazol Hikma.
English: Voriconazole has not been studied in patients with severe chronic hepatic cirrhosis (Child-Pugh C).
Croatian: Vorikonazol nije ispitivan u bolesnika s teškom kroničnom cirozom jetre (Child-Pugh stadij C).
English: Oral bioavailability may, however, be limited in paediatric patients with malabsorption and very low body weight for their age.
Croatian: Međutim, bioraspoloživost nakon peroralne primjene može biti ograničena u pedijatrijskih bolesnika s malapsorpcijom i vrlo malom tjelesnom težinom za njihovu dob.
English: Instances of hepatic reactions were noted to occur primarily in patients with serious underlying medical conditions (predominantly haematological malignancy).
Croatian: Primijećeno je da se jetrene reakcije pojavljuju prvenstveno u bolesnika s teškim popratnim bolestima (pretežno s malignim hematološkim bolestima).
English: The overall incidence of transaminase increases >3 xULN (not necessarily comprising an adverse event) in the voriconazole clinical programme was 18.0% (319/1768) in adults and 25.8% (73/283) in paediatric subjects who received voriconazole for pooled therapeutic and prophylaxis use.
Croatian: Ukupna incidencija povećanja vrijednosti transaminaza >3 x ULN (ne nužno uključujući i nuspojavu) u ispitanika koji su u kliničkim ispitivanjima primali vorikonazol iznosila je 18,0 % (319/1768) ) u odraslih i 25,8% (73/283) kod pedijatrijskih ispitanika koji su primili vorikonazol u kombiniranu terapeutskoprofilaktičku svrhu.
English: • Oxycodone and other long acting opiates such as hydrocodone (used for moderate to severe pain)
Croatian: • oksikodon i ostale opijate dugog djelovanja, kao što je hidrokodon (koriste se za ublažavanje umjerene do jake boli)
English: R-methadone (active) Cmax ↑ 31% R-methadone (active) AUCτ ↑ S-methadone Cmax ↑ 65% S-methadone AUCτ ↑ 103%
Croatian: R-metadon (aktivni) Cmax ↑31% R-metadon (aktivni) AUCτ ↑ 47% S-metadon Cmax ↑65% S-metadon AUCτ ↑103%
English: - If you have any further questions, ask your doctor,pharmacist or nurse.
Croatian: - Ako imate dodatnih pitanja, obratite se svom liječniku, ljekarniku ili medicinskoj sestri.
English: The breakthrough IFI rate to Day 180 and the primary endpoint of the study, which is Success at Day 180, for patients with AML and myeloablative conditioning regimens respectively, is presented in the table below:
Croatian: Stopa pojave invazivne gljivične infekcije (IFI) do 180. dana i primarni ishod ispitivanja, tj. uspjeh na 180. dan, za bolesnike s akutnom mijeloičnom leukemijom (AML), odnosno s mijeloablativnim postupkom, prikazani su u tablici u nastavku:
English: It is recommended that all patients, including children, avoid exposure to direct sunlight during VORICONAZOLE HIKMA treatment and use measures such as protective clothing and sunscreen with high sun protection factor (SPF).
Croatian: Preporučuje se da svi bolesnici tijekom primjene lijeka VORIKONAZOL HIKMA, uključujući djecu, izbjegavaju izlaganje izravnoj sunčevoj svjetlosti te koriste zaštitnu odjeću i sredstva za zaštitu od sunca s visokim zaštitnim faktorom (SPF).
English: The medicines in the following list must not be taken during your Voriconazole Hikma treatment:
Croatian: Lijekovi navedeni u sljedećem popisu ne smiju se uzimati za vrijeme liječenja lijekom Vorikonazol Hikma:
English: In an overdose, haemodialysis may assist in the removal of voriconazole and SBECD from the body.
Croatian: U slučaju predoziranja hemodijaliza može pomoći u odstranjivanju vorikonazola i SBECD-a iz organizma.
English: Depending on your response to treatment, your doctor may decrease the dose to 3 mg/kg twice daily.
Croatian: Ovisno o Vašem odgovoru na liječenje, liječnik može smanjiti dnevnu dozu na 3 mg/kg dva puta na dan.
English: If the liver function tests become markedly elevated, Voriconazole Hikma should be discontinued, unless the medical judgment of the risk-benefit of the treatment for the patient justifies continued use.
Croatian: Ako testovi funkcije jetre postanu značajno povišeni, mora se prekinuti uzimanje lijeka Vorikonazol Hikma, osim ako medicinska procjena rizika i koristi liječenja za pacijenta opravdava nastavak korištenja.
English: Dose reduction of benzodiazepines should be considered.
Croatian: Treba razmotriti smanjenje doze benzodiazepina.
English: Careful monitoring of phenytoin plasma levels is recommended.
Croatian: Preporučuje se pažljivo praćenje razine fenitoina u plazmi.
English: Low dose (100 mg BID)*
Croatian: Niska doza (100 mg BID)*
English: In the primary analysis, successful response as assessed by a Data Review Committee (DRC) blinded to study medicinal product was defined as resolution/improvement in all clinical signs and symptoms of infection with eradication of Candida from blood and infected deep tissue sites at 12 weeks after the end of therapy (EOT).
Croatian: Data Review Committee - DRC) koje nije znalo koji su lijek ispitanici uzimali, pozitivan odgovor definiran kao povlačenje/poboljšanje svih kliničkih znakova i simptoma infekcije uz eradikaciju kandide iz krvi i inficiranih dubokih tkiva 12 tjedana po završetku liječenja.
English: : Successful response to voriconazole therapy was seen in 16 (6 complete, 10 partial responses) of 28 patients with S. apiospermum and in 2 (both partial responses) of 7 patients with S. prolificans infection.
Croatian: Vrsta iz roda Scedosporium: Pozitivan odgovor na liječenje vorikonazolom postignut je u 16 (6 potpunih, 10 djelomičnih odgovora) od 28 bolesnika s infekcijom uzročnika S. apiospermum te u 2 (oba djelomična odgovora) od 7 bolesnika s infekcijom uzročnika S. prolificans.
English: Dose reduction of vinca alkaloids should be considered.
Croatian: Treba razmotriti smanjenje doze vinka alkaloida.
English: However, a trend towards a higher frequency of liver enzyme elevations, reported as adverse events in clinical trials was observed in paediatric patients as compared to adults (14.2% transaminases increased in paediatrics compared to 5.3% in adults).
Croatian: Međutim, u odnosu na odrasle bolesnike, kod pedijatrijskih je bolesnika u kliničkim ispitivanjima, kao nuspojava, zabilježen trend povećanja učestalosti povišenog enzima jetre (14,2% povećanih tranzaminaza u pedijatrijskih bolesnika u odnosu na 5,3% kod odraslih).
English: • Tell your doctor immediately if you develop o sunburn o severe skin rash or blisters o bone pain.
Croatian: • odmah recite svom liječniku ako razvijete: o opekline od sunca o teški osip ili mjehure na koži o osjetite bol u kostima
English: A 4 hour haemodialysis session does not remove a sufficient amount of voriconazole to warrant dose adjustment.
Croatian: Tijekom četverosatne hemodijalize ne odstrani se dovoljna količina vorikonazola koja bi opravdavala prilagodbu doze.
English: - Reminds HCPs of use of the HCP Checklist and the Patient Alert Card and how to obtain additional copies.
Croatian: - Podsjeća zdravstvene radnike na korištenje kontrolnog spiska i kartice s upozorenjima za bolesnika te kako dobiti dodatne primjerke.
English: In addition VORICONAZOLE HIKMA has been associated with phototoxicity including reactions such as ephelides, lentigo, actinic keratosis and pseudoporphyria.
Croatian: HIKMA se povezuje s fototoksičnošću, uključujući reakcije kao što su pjege, lentigo, aktinička keratoza i pseudoporfirija.
English: No significant differences in Cmax and AUCτ were observed between healthy elderly females (≥ 65 years) and healthy young females (18-45 years).
Croatian: Nisu zabilježene značajne razlike u Cmax i AUCτ između zdravih starijih žena (≥ 65 godina) i zdravih mladih žena (18-45 godina).
English: If VORICONAZOLE HIKMA is continued, however, dermatologic evaluation should be performed on a systematic and regular basis, to allow early detection and management of premalignant lesions.
Croatian: Ako se, usprkos tome, nastavlja primjena lijeka VORIKONAZOL HIKMA, dermatološku procjenu treba provoditi sistematično i redovito, kako bi se omogućila rana detekcija i liječenje premalignih lezija.
English: An impurity, present in SBECD, has been shown to be an alkylating mutagenic agent with evidence for carcinogenicity in rodents.
Croatian: Pokazalo se da je onečišćenje prisutno u SBECD-u alkilirajuća mutagena tvar, dokazano kancerogena u glodavaca.
English: Not for administration as a bolus injection.
Croatian: Nije za primjenu u obliku bolus injekcije.
English: Nine subjects in the voriconazole group and five in the amphotericin B followed by fluconazole group also had mycologically proven infection in deep tissue.
Croatian: Devet bolesnika iz skupine liječene vorikonazolom i 5 iz skupine liječene amfotericinom B pa potom flukonazolom, imali su i mikološki dokazanu infekciju dubokih tkiva.
English: When initiating voriconazole in patients already receiving omeprazole doses of 40 mg or above, it is recommended that the omeprazole dose be halved.
Croatian: Kad se započinje primjena vorikonazola u bolesnika koji već primaju omeprazol u dozi od 40 mg ili većoj, preporučuje se prepoloviti dozu omeprazola.
English: As Voriconazole Hikma has been known to affect the liver and the kidney, your doctor should monitor the function of your liver and kidneys by doing blood tests.
Croatian: S obzirom da je poznato da Vorikonazol Hikma utječe na jetru i bubrege, liječnik Vam mora pratiti funkciju jetre i bubrega putem krvnih pretraga.
English: Voriconazole Hikma is presented in packs of 1 or 5 glass vials as a powder for solution for infusion.
Croatian: Hikma je dostupan u pakiranjima od 1 ili 5 staklenih bočica u obliku praška za otopinu za infuziju.
English: Patients 40 kg and above**
Croatian: Bolesnici tjelesne težine 40 kg i više**
English: Increased ciclosporin levels have been associated with nephrotoxicity.
Croatian: Povišene razine ciklosporina povezuju se s nefrotoksičnošću.
English: Studies conducted in Caucasian and Japanese healthy subjects have shown that poor metabolisers have, on average, 4-fold higher voriconazole exposure (AUCτ) than their homozygous extensive metaboliser counterparts.
Croatian: Ispitivanja provedena u zdravih bijelaca i Japanaca pokazala su da spori metabolizatori imaju prosječno 4 puta veću izloženost vorikonazolu (AUCτ ) nego odgovarajući im homozigotni brzi metabolizatori.
English: • Warfarin and other anticoagulants (e.g. phenprocoumon, acenocoumarol; used to slow down clotting of the blood)
Croatian: • varfarin i ostale antikoagulanse (npr. fenprokumon, acenokumarol; primjenjuju se za usporavanje zgrušavanja krvi)
English: Repeated-dose toxicity studies with voriconazole indicated the liver to be the target organ.
Croatian: Ispitivanja toksičnosti ponovljenih doza vorikonazola pokazala su da je jetra ciljni organ.
English: 9 mg/kg twice daily (a maximum dose of 350 mg twice daily)
Croatian: 9 mg/kg dvaput na dan (maksimalna doza je 350 mg dvaput na dan)
English: Investigations blood creatinine increased blood urea increased, blood cholesterol increased
Croatian: Pretrage povišene vrijednosti kreatinina povišene vrijednosti ureje u krvi, povišene vrijednosti kolesterola
English: The terminal half-life of voriconazole depends on dose and is approximately 6 hours at 200 mg (orally).
Croatian: Terminalni poluvijek vorikonazola ovisan je o dozi i iznosi približno 6 sati pri dozi od 200 mg (peroralno).
English: Voriconazole also significantly increases efavirenz plasma concentrations (see section 4.5, for lower doses see section 4.4).
Croatian: Vorikonazol također značajno povećava koncentraciju efavirenza u plazmi (vidjeti dio 4.5; za manje doze vidjeti dio 4.4).
English: In vitro, voriconazole displays broad-spectrum antifungal activity with antifungal potency against Candida species (including fluconazole resistant C. krusei and resistant strains of C. glabrata and C. albicans) and fungicidal activity against all Aspergillus species tested.
Croatian: Vorikonazol pokazuje širok spektar antifungalne aktivnosti in vitro, sa snažnim djelovanjem protiv vrsta iz roda Candida (uključujući C. krusei rezistentnu na flukonazol i rezistentne sojeve C. glabrata i C. albicans) te fungicidnim djelovanjem protiv svih ispitanih vrsta iz roda Aspergillus.
English: Specimens for fungal culture and other relevant laboratory studies (serology, histopathology) should be obtained prior to therapy to isolate and identify causative organisms.
Croatian: Prije početka liječenja treba uzeti uzorke za mikokulturu i druge relevantne laboratorijske pretrage (serologija, histopatologija) kako bi se izoliralo i identificiralo uzročnike.
English: • Phototoxicity
Croatian: • Fototoksičnost
English: The efficacy of voriconazole compared to the regimen of amphotericin B followed by fluconazole in the primary treatment of candidaemia was demonstrated in an open, comparative study.
Croatian: Djelotvornost vorikonazola u odnosu na primjenu režima liječenja amfotericinom B nakon kojeg se davao flukonazol u primarnom liječenju kandidemije dokazana je u otvorenom komparativnom ispitivanju.
English: A comparison of the paediatric and adult population pharmacokinetic data indicated that the predicted total exposure (AUCτ) in children following administration of a 9 mg/kg IV loading dose was comparable to that in adults following a 6 mg/kg IV loading dose.
Croatian: Usporedba farmakokinetičkih podataka u pedijatrijskoj i odrasloj populaciji pokazala je da je predviđena ukupna izloženost (AUCτ) u djece nakon intravenske primjene udarne doze od 9 mg/kg bila usporediva s onom u odraslih nakon intravenske primjene udarne doze od 6 mg/kg.
English: Dermatological reactions were very common in patients treated with voriconazole in clinical trials, but these patients had serious underlying diseases and were receiving multiple concomitant medicinal products.
Croatian: Kožne su reakcije bile vrlo česte u bolesnika liječenih vorikonazolom u kliničkim ispitivanjima, no to su bili bolesnici s ozbiljnim osnovnim bolestima koji su istodobno primali velik broj lijekova.
English: Very common: may affect more than 1 in 10 people
Croatian: Druge nuspojave Vrlo česte: mogu se javiti u više od 1 na 10 osoba
English: Chemical and physical stability of the of the diluted solutions for infusion has been demonstrated for 36 hours at 2°C to 8°C followed by 3 hours at room temperature.
Croatian: Za razrijeđenu otopinu za infuziju kemijska i fizikalna stabilnost dokazana je tijekom 36 sati na 2°C do 8°C nakon čega slijedi 3 sata na sobnoj temperaturi.
English: No subject experienced an interval exceeding the potentially clinically relevant threshold of 500 msec.
Croatian: Niti u jednog ispitanika nije primijećeno produljenje intervala preko potencijalno klinički značajnog praga od 500 ms.
English: The MITT group included 40 patients with prior IFI, including 31 with aspergillosis, 5 with candidiasis, and 4 with other IFI.
Croatian: Skupina MITT obuhvaćala je 40 bolesnika s prethodnom invazivnom gljivičnom infekcijom, uključujući 31 s aspergilozom, 5 s kandidijazom i 4 s drugom invazivnom gljivičnom infekcijom.
English: Tell your doctor if you are taking any of the following medicines, as a dose adjustment or monitoring may be required to check that the medicines and/or Voriconazole Hikma are still having the desired effect:
Croatian: Obavijestite svog liječnika ako uzimate neki od sljedećih lijekova, jer će možda trebati prilagoditi dozu lijeka ili provjeravati imaju li oni i/ili Vorikonazol Hikma i dalje željeni učinak:
English: Prophylaxis of invasive fungal infections in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients.
Croatian: Profilaksa invazivnih gljivičnih infekcija u visokorizičnih primatelja alogene transplantacije hematopoetskih matičnih stanica (HSCT, engl. hematopoietic stem cell transplant).
English: - Reminds HCPs to discuss with the patient/care giver the risks of phototoxicity/skin SCC and hepatotoxicity, what to look for, how and when to seek immediate attention.
Croatian: - Podsjeća zdravstvene radnike da razgovaraju s bolesnikom/skrbnikom o riziku fototoksičnosti/SCCa i toksičnosti za jetru, što tražiti, kako i kada potražiti hitnu pomoć.
English: Four additional patients with fusariosis had an infection caused by several organisms; two of them had a successful outcome.
Croatian: Još su 4 bolesnika s fuzariozom imala infekciju izazvanu više nego jednim uzročnikom, a u 2 od njih je ishod liječenja bio pozitivan.
English: The visual impairmentswere generally mild, rarely resulted in discontinuation and were not associated with long-term sequelae.
Croatian: Oštećenja vida su uglavnom bila blaga, rijetko su dovela do prekida primjene lijeka i nisu bila povezana s dugoročnim posljedicama.
English: There have been reports of squamous cell carcinoma of the skin in patients treated with voriconazole for long periods of time; the mechanism has not been established (see section 4.4).
Croatian: Prijavljen je karcinom skvamoznih stanica na koži u bolesnika koji su liječeni vorikonazolom kroz duži vremenski period, mehanizam djelovanja još nije utvrđen (vidjeti dio 4.4).
English: • Benzodiazepines (e.g., midazolam, triazolam) (used for severe insomnia and stress)
Croatian: • benzodiazepine (npr. midazolam, triazolam) (koriste se kod teške nesanice i stresa)
English: The pharmacokinetics of voriconazole have been characterised in healthy subjects, special populations and patients.
Croatian: Određena su farmakokinetička svojstva vorikonazola u zdravih ispitanika, u posebnim populacijskim skupinama te u bolesnika.
English: Dose reduction of statins should be considered.
Croatian: Treba razmotriti smanjenje doze statina.
English: In a study in healthy volunteers investigating the impact of voriconazole on retinal function, voriconazole caused a decrease in the electroretinogram (ERG) waveform amplitude.
Croatian: U zdravih je dobrovoljaca provedeno ispitivanje utjecaja vorikonazola na funkciju mrežnice, u kojem je vorikonazol uzrokovao smanjenje valnih amplituda elektroretinograma (ERG).
English: Women of child-bearing potential must always use effective contraception during treatment.
Croatian: Žene reproduktivne dobi uvijek moraju koristiti učinkovitu kontracepciju tijekom liječenja vorikonazolom.
English: Standard genotoxicity and reproduction studies with the excipient SBECD reveal no special hazard for humans.
Croatian: Stadardna ispitivanja genotoksičnosti i reproduktivne toksičnosti pomoćne tvari SBECD-a nisu otkrila poseban rizik za ljude.
English: • Everolimus (used for treating advanced kidney cancer and in transplant patients)
Croatian: • everolimus (koristi se za liječenje uznapredovalog raka bubrega i u bolesnika s presatkom organa).
English: Aspergillus infections - efficacy in aspergillosis patients with poor prognosis Voriconazole has in vitro fungicidal activity against Aspergillus spp.
Croatian: Infekcije uzročnikom Aspergillus - djelotvornost u bolesnika s aspergilozom s lošom prognozom Vorikonazol in vitro djeluje fungicidno na vrste iz roda Aspergillus.
English: MIC breakpoint (mg/L)
Croatian: Granična vrijednost MIK-a (mg/L)
English: Dose reduction of sulfonylureas should be considered.
Croatian: Treba razmotriti smanjenje doze sulfonilureje.
English: Each vial contains 217.6 mg of sodium.
Croatian: Jedna bočica sadrži 217,6 mg natrija.
English: Hepatic function should be monitored in both children and adults.
Croatian: Funkciju jetre je potrebno pratiti i u djece i u odraslih.
English: During oral administration of 200 mg or 300 mg twice daily for 14 days in patients at risk of aspergillosis (mainly patients with malignant neoplasms of lymphatic or haematopoietic tissue), the observed pharmacokinetic characteristics of rapid and consistent absorption, accumulation and non-linear pharmacokinetics were in agreement with those observed in healthy subjects.
Croatian: Tijekom 14-dnevne peroralne primjene vorikonazola u dozi od 200-300 mg dvaput na dan u bolesnika s rizikom za razvoj aspergiloze (uglavnom bolesnika s malignim neoplazmama limfatičkog i hematopoetskog sustava) opažena farmakokinetička svojstva - brza i stabilna apsorpcija, kumulacija i nelinearna farmakokinetika - odgovarala su onima opaženima u zdravih ispitanika.
English: Voriconazole was administered intravenously with a loading dose of 6 mg/kg every 12 hours for the first 24 hours followed by a maintenance dose of 4 mg/kg every 12 hours for a minimum of seven days.
Croatian: Vorikonazol se primjenjivao intravenski, počevši s udarnom dozom od 6 mg/kg svakih 12 sati tijekom prva 24 sata i nastavljajući dozom održavanja od 4 mg/kg svakih 12 sati tijekom najmanje 7 dana.
English: Voriconazole Cmax ↑ 57% Voriconazole AUCτ ↑ 79% Fluconazole Cmax ND Fluconazole AUCτ ND
Croatian: Vorikonazol Cmax ↑57% Vorikonazol AUCτ ↑ 79% Flukonazol Cmax ND Flukonazol AUCτ ND
English: Patients being treated with voriconazole are likely to be treated concomitantly with nephrotoxic medicinal products and have concurrent conditions that may result in decreased renal function (see section 4.8).
Croatian: Tijekom liječenja vorikonazolom bolesnici će vjerojatno istodobno primati neki nefrotoksičan lijek i imati popratnu bolest koja može dovesti do slabljenja bubrežne funkcije (vidjeti dio 4.8).
English: Caution should be used in prescribing Voriconazole Hikma to patients with hypersensitivity to other azoles (see also section 4.8).
Croatian: Potreban je oprez kod propisivanja lijeka Vorikonazol Hikma bolesnicima preosjetljivima na ostale azole (vidjeti i dio 4.8).
English: • Statins (e.g., atorvastatin, simvastatin) (used for lowering cholesterol)
Croatian: • statine (npr. atorvastatin, simvastatin) (koriste se za snižavanje razine kolesterola)
English: The intravenous vehicle, SBECD, is haemodialysed with a clearance of 55 ml/min.
Croatian: Intravenski vehikulum, SBECD, odstranjuje se hemodijalizom, klirensom od 55 ml/min.