FrancophonIA/ELRC3.0 huggingface dataset:
English: Concomitant use of medicinal products that are inducers of CYP3A4, such as carbamazepine, phenobarbital and phenytoin may reduce indinavir plasma concentrations.
Slovenian: Sočasna uporaba zdravil, ki zavirajo CYP3A4, kot so karbamazepin, fenobarbital in fenitoin, lahko zmanjša koncentracijo indinavirja v plazmi.
English: • If you cannot take it without food then take CRIXIVAN with a low-fat light meal.
Slovenian: • Če zdravila CRIXIVAN ne morete vzeti brez hrane, potem ga vzemite z lahkim obrokom, ki ne vsebuje veliko maščob.
English: Crystals have been seen in the urine of rats, one monkey, and one dog.
Slovenian: V urinu podgan, ene opice in enega psa so našli kristale.
English: When CRIXIVAN is used with ritonavir, consult the Summary of Product Characteristics of ritonavir for additional contraindications.
Slovenian: Kadar se zdravilo CRIXIVAN uporablja skupaj z ritonavirjem, glejte Povzetek glavnih značilnosti ritonavirja za dodatne kontraindikacije.
English: The bioavailability of a single 800-mg dose of indinavir was approximately 65 % (90 % CI, 58 - 72 %).
Slovenian: Biološka uporabnost enkratnega 800 mg odmerka indinavirja je bila približno 65 % (90 % CI - "confidential interval", 58-72 %).
English: 3 years for HDPE bottles containing 90 and 180 hard capsules.
Slovenian: 3 leta za HDPE plastenke z 90 in 180 trdimi kapsulami.
English: Adequate hydration is recommended in all patients on indinavir (see sections 4.2 and 4.8).
Slovenian: Pri vseh bolnikih, ki se zdravijo z indinavirjem, priporočamo zadostno oskrbo s tekočino (glejte poglavji 4.2 in 4.8).
English: In zidovudine experienced patients, indinavir, zidovudine and lamivudine in combination compared with lamivudine added to zidovudine reduced the probability of AIDS defining illness or death (ADID) at 48 weeks from 13 % to 7 %.
Slovenian: Pri bolnikih, zdravljenih z zidovudinom, je kombinacija indinavirja, zidovudina in lamivudina v primerjavi z lamivudinom dodanim zidovudinu zmanjšala verjetnost določitve bolezni AIDS ali smrti (ADID) po 48 tednih s 13 % na 7 %.
English: Similarly, in antiretroviral naive patients, indinavir with and without zidovudine compared with zidovudine alone reduced the probability of ADID at 48 weeks from 15 % with zidovudine alone to approximately 6 % with indinavir alone or in combination with zidovudine.
Slovenian: Podobno je pri bolnikih, ki se še niso zdravili s protiretrovirusnimi zdravili, indinavir z ali brez zidovudina v primerjavi s samim zidovudinom zmanjšal verjetnost ADID po 48 tednih s 15 % pri zidovudinu samem na približno 6 % pri indinavirju samem ali v kombinaciji z zidovudinom.
English: • venlafaxine, trazodone - used for depression
Slovenian: • venlafaksin, trazodon - za depresijo
English: Administration of indinavir to pregnant Rhesus monkeys during the third trimester did not cause a similar exacerbation in neonates; however, only limited placental transfer of indinavir occurred.
Slovenian: Uporaba indinavirja v obdobju tretjega trimesečja brejosti pri mladičih opic Rhesus ni povzročila podobnega poslabšanja; prišlo je le do omejenega prehoda indinavirja preko posteljice.
English: Nephrolithiasis has occurred with indinavir therapy in adult patients with a cumulative frequency of 12.4 % (range across individual trials: 4.7 % to 34.4 %).
Slovenian: Pri uporabi indinavirja so se pri odraslih bolnikih pojavili ledvični kamni s skupno pogostnostjo pojavljanja 12,4 % (razpon med posameznimi študijami: 4,7 % do 34,4 %).
English: • liver problems - people with ‘chronic hepatitis B or C' or ‘cirrhosis' who are treated with ‘antiretroviral' medicines are more likely to have serious and potentially fatal liver side effects with this medicine.
Slovenian: • težave z jetri - ljudje s 'kroničnim hepatitisom B ali C' ali 'cirozo', ki se zdravijo z 'protiretrovirusnimi' zdravili, so bolj dovzetni za resne in potencialno smrtne neželene učinke na jetra.
English: Indinavir binds reversibly to the protease active site and inhibits competitively the enzyme, thereby preventing cleavage of the viral precursor polyproteins that occurs during maturation of the newly formed viral particle.
Slovenian: Indinavir se reverzibilno veže na aktivno mesto proteaze, kompetitivno zavira encim ter tako preprečuje cepitev virusnih prekurzorskih poliproteinov, do katere pride med zorenjem novega virusnega delca.
English: The safety and efficacy of indinavir has not been established in patients with significant underlying liver disorders.
Slovenian: Varnost in učinkovitost indinavirja pri bolnikih s pomembnimi, že obstoječimi motnjami v delovanju jeter ni bila dokazana.
English: • amlodipine, felodipine, nifedipine, nicardipine, digoxin, diltiazem - used for high blood pressure and some heart problems.
Slovenian: • amlodipin, felodipin, nifedipin, nikardipin, digoksin, diltiazem - za zvišan krvni tlak in določene okvare srca
English: CRIXIVAN should be administered by physicians who are experienced in the treatment of HIV infection.
Slovenian: Zdravilo CRIXIVAN mora predpisati zdravnik, ki ima izkušnje z zdravljenjem okužbe s HIV.
English: 3; and the mean increase in percent CD4 cell counts was 1.2 %.
Slovenian: 3 ter povprečno povečanje odstotka števila CD4 celic 1,2 %.
English: The maximum non-lethal oral dose of indinavir was at least 5,000 mg/kg in rats and mice, the highest dose tested in acute toxicity studies.
Slovenian: Največji peroralni odmerek indinavirja pri podganah in miših, ki ni povzročil smrti, je bil najmanj 5000 mg/kg, kar je tudi najvišji odmerek, ki so ga preizkusili v raziskavah akutne toksičnosti.
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Slovenian: Pri bolnikih s predhodnimi motnjami delovanja jeter, vključno s kroničnim aktivnim hepatitisom, je pogostnost funkcijskih nepravilnosti jeter med kombiniranim protiretrovirusnim zdravljenjem večja in jih je treba spremljati skladno z ustaljeno prakso.
English: Ritonavir may induce glucuronidation of methadone.
Slovenian: Ritonavir lahko inducira glukuronidacijo metadona.
English: The use of rifampicin with indinavir is contraindicated.
Slovenian: Uporaba rifampicina skupaj z indinavirjem je kontraindicirana.
English: Patients with coexisting conditions
Slovenian: Bolniki s sočasnimi bolezenskimi stanji
English: By intent to treat analysis 65 % of patients had HIV RNA < 400 copies/mL and 50 % had viral load < 50 copies/mL; by on-treatment analysis 96 % of patients had HIV RNA < 400 copies/mL and 74 % had viral load < 50 copies/mL.
Slovenian: Pri analizi populacije, ki so jo nameravali zdraviti, je imelo 65 % bolnikov HIV RNA < 400 kopij/ml, 50 % pa virusno breme < 50 kopij/ml; pri analizi zdravljene populacije je imelo 96 % bolnikov HIV RNA < 400 kopij/ml, 74 % pa virusno breme < 50 kopij/ml.
English: What CRIXIVAN looks like and contents of the pack
Slovenian: Izgled zdravila CRIXIVAN in vsebina pakiranja
English: Once a diagnosis is apparent, appropriate measures for the treatment of haemolytic anaemia should be instituted which may include discontinuation of indinavir.
Slovenian: Ko je diagnoza postavljena, je treba uvesti ustrezne ukrepe za zdravljenje hemolitične anemije in, če je treba, celo prekiniti z jemanjem indinavirja.
English: • rash or dry skin
Slovenian: • izpuščaj ali suha koža
English: Indinavir AUC:  28 % Nevirapine:  (CYP3A induction)
Slovenian: AUC indinavirja:  28 % Nevirapin:  (indukcija CYP3A)
English: Administration with light meals (e.g., dry toast with jam or fruit conserve, apple juice, and coffee with skimmed or fat-free milk and sugar or corn flakes, skimmed or fat-free milk and sugar) resulted in plasma concentrations comparable to the corresponding fasted values.
Slovenian: Pri jemanju skupaj z lahkim obrokom (npr. prepečenec z marmelado ali konzerviranim sadjem, jabolčni sok in kava s posnetim mlekom ali mlekom brez maščobe in sladkor; koruzni kosmiči, posneto mleko ali mleko brez maščobe in sladkor) so bile plazemske koncentracije primerljive s tistimi po zaužitju na tešče.
English: A normal (acidic) gastric pH may be necessary for optimum absorption of indinavir whereas acid rapidly degrades didanosine which is formulated with buffering agents to increase pH.
Slovenian: Za optimalno absorpcijo indinavirja bo morda potreben pH normalne (kislinske) želodčne kisline, pri čemer kislina hitro razgradi didanozin, ki se uporablja v formulaciji s pufrom za povečanje pH.
English: What CRIXIVAN is and what it is used for What you need to know before you take CRIXIVAN How to take CRIXIVAN
Slovenian: Kaj je zdravilo CRIXIVAN in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo CRIXIVAN Kako jemati zdravilo CRIXIVAN Možni neželeni učinki
English: • ritonavir - 100 mg - taken twice a day.
Slovenian: • Ritonavir - 100 mg - vzet dvakrat na dan.
English: No dose recommendations for indinavir/ritonavir with rifabutin could be given, therefore the combination is not recommended.
Slovenian: Pri kombinaciji indinavirja/ritonavirja in rifabutina ni mogoče dati priporočil za odmerjanje, zato ta kombinacija ni priporočljiva.
English: Immune Reactivation Syndrome
Slovenian: Sindrom imunske reaktivacije:
English: Therefore, other substances that either share this metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of indinavir.
Slovenian: Tako lahko snovi, ki se presnavljajo preko te presnovne poti ali kako drugače vplivajo na aktivnost CYP3A4, vplivajo na farmakokinetiko indinavirja.
English: Indinavir AUC:  11 % Sildenafil AUC  340 %
Slovenian: AUC indinavirja:  11 % AUC sildenafila  340 %
English: When indinavir is administered as monotherapy resistant viruses rapidly emerge (see section 5.1).
Slovenian: Če se indinavir uporablja kot samostojno zdravilo, se hitro pojavijo rezistentni virusi (glejte poglavje 5.1).
English: CRIXIVAN contains a substance called indinavir.
Slovenian: Zdravilo CRIXIVAN vsebuje učinkovino, imenovano indinavir.
English: In one comparative trial, combination therapy with nucleoside analogues (triple therapy with zidovudine plus didanosine) conferred protection against the selection of virus expressing at least one resistanceassociated amino acid substitution to both indinavir (from 13/24 to 2/20 at therapy week 24) and to the nucleoside analogues (from 10/16 to 0/20 at therapy week 24).
Slovenian: V primerjalni raziskavi je kombinirano zdravljenje z nukleozidnimi analogi (trojno zdravljenje z zidovudinom in didanozinom) potrdilo zaščito pred selekcijo virusa, ki ima izraženo vsaj eno aminokislinsko substitucijo, povezano z rezistenco na indinavir (od 13/24 do 2/20 v 24. tednu zdravljenja) in na nukleozidne analoge (od 10/16 do 0/20 v 24. tednu zdravljenja).
English: Similarly, indinavir might also modify the pharmacokinetics of other substances that share this metabolic pathway.
Slovenian: Podobno lahko tudi indinavir vpliva na farmakokinetiko drugih učinkovin, ki se presnavljajo po omenjeni poti.
English: The crystals have not been associated with medicinal product -induced renal injury.
Slovenian: Kristali niso bili povezani s poškodbo ledvic, povzročeno z zdravilom.
English: No data has been obtained comparing rifabutin 150 mg QD in combination with indinavir 800 mg TID with a reference dose of 150 mg rifabutin alone)
Slovenian: Ni podatkov o primerjavi rifabutina 150 mg QD v kombinaciji z indinavirjem 800 mg TID in referenčnega odmerka samostojnega rifabutina 150 mg.)
English: Excipient with known effect Each 400 mg capsule contains 149.6 mg of lactose.
Slovenian: Pomožna snov z znanim učinkom Ena 400 mg kapsula vsebuje 149,6 mg laktoze.
English: Nephrolithiasis, including flank pain with or without haematuria (including microscopic haematuria), has been reported in approximately 10 % (252/2,577) of patients receiving CRIXIVAN in clinical trials at the recommended dose compared to 2.2 % in the control arms.
Slovenian: O ledvičnih kamnih, vključno z bolečino v ledvenem predelu in s hematurijo (vključno z mikrohematurijo) ali brez nje, so poročali pri približno 10 % bolnikov (252/2.577), ki so v kliničnih preskušanjih prejemali zdravilo CRIXIVAN v priporočenih odmerkih, v primerjavi z 2,2 % bolnikov iz kontrolne skupine.
English: Coadministration of ritonavir and ketoconazole caused an increased incidence of gastrointestinal and hepatic adverse events.
Slovenian: Sočasna uporaba ritonavirja in ketokonazola je povzročila povečano incidenco gastrointestinalnih in jetrnih neželenih učinkov.
English: Effects on viral load were consistently more pronounced in patients treated with indinavir in combination with nucleoside analogues, but the proportion of patients with serum viral RNA below the limit of quantification (500 copies/mL) varied between studies, at week 24 from 40 % to more than 80 %.
Slovenian: Učinki na virusno obremenitev so bili pri bolnikih, zdravljenih z indinavirjem v kombinaciji z nukleozidnimi analogi, dosledno bolj izraziti, vendar je delež bolnikov s serumsko virusno RNA pod mejo določitve (500 kopij/ml) med raziskavami v 24. tednu nihal od 40 % do več kot 80 %.
English: In clinical trials in paediatric patients (≥ 3 years), the adverse reaction profile was similar to that for adult patients except for a higher frequency of nephrolithiasis of 29 % (20/70) in paediatric patients treated with CRIXIVAN.
Slovenian: V kliničnih preskušanjih pri pediatričnih bolnikih (≥ 3 leta) je bil profil neželenih učinkov podoben kot pri odraslih bolnikih, z izjemo večje pogostnosti ledvičnih kamnov pri pediatričnih bolnikih (29 % (20/70)), ki so prejemali zdravilo CRIXIVAN.
English: • do not take CRIXIVAN with food that is high in calories, fat and protein.
Slovenian: • ne jemljete zdravila CRIXIVAN s hrano, ki je visokokalorična, z veliko maščobami in proteini.
English: The interaction of indinavir or indinavir/ritonavir with pravastatin or fluvastatin is not known (see section 4.5).
Slovenian: Medsebojno delovanje indinavirja ali indinavirja/ritonavirja s pravastatinom ali fluvastatinom ni znano (glejte poglavje 4.5).
English: Among patients experiencing viral RNA rebound during indinavir monotherapy at 800 mg q8h, substitutions at only three of these sites were observed in the majority of patients: V82 (to A or F), M46 (to I or L), and L10 (to I or R).
Slovenian: Med bolniki, ki so bili zdravljeni samo z 800 mg indinavirja vsakih 8 ur in je prišlo do ponovnega izbruha virusne RNA, so pri večini bolnikov substitucije opazili samo na treh mestih: V82 (na A ali F), M46 (na I ali L) in L10 (na I ali R).
English: Zidovudine AUC: ↑ 39 % Zidovudine Cmin: 
Slovenian: AUC zidovudina: ↑ 39 % Cmin zidovudina: 
English: SPECIAL STORAGE CONDITIONS:
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE
English: Hyperbilirubinaemia, reported predominantly as elevated indirect bilirubin, has occurred in 14 % of patients during treatment with indinavir.
Slovenian: Hiperbilirubinemija, o kateri so poročali večinoma kot o zvišani koncentraciji indirektnega bilirubina, se je med zdravljenjem z indinavirjem pojavila pri 14 % bolnikov.
English: HIV 1 patient isolates with reduced susceptibility to indinavir expressed varying patterns and degrees of cross-resistance to a series of diverse HIV PIs, including ritonavir and saquinavir.
Slovenian: Izolati bolnikov, okuženih s HIV-1, z zmanjšano občutljivostjo na indinavir, so kazali različne vzorce in stopnje navzkrižne rezistence na vrsto različnih zaviralcev HIV proteaze, vključno z ritonavirjem in sakvinavirom.
English: Administration of indinavir with a meal high in calories, fat, and protein resulted in a blunted and reduced absorption with an approximate 80 % reduction in AUC and an 86 % reduction in Cmax.
Slovenian: Pri jemanju indinavirja skupaj z visokokaloričnim obrokom hrane z veliko maščobami in beljakovinami je prišlo do upočasnjene in zmanjšane absorpcije z okrog 80 % zmanjšanjem AUC in 86 % zmanjšanjem Cmax.
English: Vardenafil AUC: ↑ 16-fold
Slovenian: AUC vardenafil: ↑ 16-krat
English: There have been reports of human overdose with CRIXIVAN.
Slovenian: Poročali so o prevelikem odmerjanju zdravila CRIXIVAN pri človeku.
English: Sixty-two patients completed the study to week 96.
Slovenian: Do 96. tedna je študijo končalo 62 bolnikov.
English: 3; and the mean increase in percent CD4 cell counts was 4.2 %.
Slovenian: 3 ter povprečno povečanje odstotka števila CD4 celic 4,2 %.
English: Concomitant administration of indinavir and quetiapine may increase plasma concentrations of quetiapine leading to quetiapine-related toxicity, including coma.
Slovenian: Pri sočasni uporabi indinavirja in kvetiapina se lahko povečajo plazemske koncentracije kvetiapina, ki vodijo do s kvetiapinom povezane toksičnosti, vključno s komo.
English: These adverse reactions were: nausea (35.3 %), headache (25.2 %), diarrhoea (24.6 %), asthenia/fatigue (24.3 %), rash (19.1 %), taste perversion (19.1 %), dry skin (16.2 %), abdominal pain (14.6 %), vomiting (11.0 %), dizziness (10.7 %).
Slovenian: Ti neželeni učinki so bili: navzea (35,3 %), glavobol (25,2 %), driska (24,6 %), občutek šibkosti/utrujenosti (24,3 %), izpuščaj (19,1 %), motnje okušanja (19,1 %), suha koža (16,2 %), bolečine v trebuhu (14,6 %), bruhanje (11,0 %), omotica (10,7 %).
English: Hyperbilirubinaemia occurred more frequently at doses exceeding 2.4 g/day compared to doses less than 2.4 g/day.
Slovenian: Do hiperbilirubinemije je pogosteje prišlo pri odmerkih, višjih od 2,4 g na dan, kot pa pri odmerkih, manjših od 2,4 g na dan.
English: A boosted dose of 800 mg indinavir/100 mg ritonavir twice daily results in increased risk of adverse events.
Slovenian: Okrepljeni odmerek 800 mg indinavirja s 100 mg ritonavirja dvakrat na dan povzroči povečano tveganje neželenih učinkov.
English: Isolated asymptomatic hyperbilirubinaemia (total bilirubin  2.5 mg/dL, 43 mcmol/L) was reported predominantly as elevated indirect bilirubin and rarely associated with elevations in ALT, AST, or alkaline phosphatase, has occurred in approximately 14 % of patients treated with CRIXIVAN alone or in combination with other antiretroviral agents.
Slovenian: Do izolirane asimptomatične hiperbilirubinemije (koncentracija skupnega bilirubina ≥ 2,5 mg/dl, 43 μmol/l), o kateri so večinoma poročali kot o zvišani koncentraciji indirektnega bilirubina in, ki je bila redko povezana s povečanjem vrednosti ALT, AST ali alkalne fosfataze, je prišlo pri približno 14 % bolnikov, zdravljenih z zdravilom CRIXIVAN samim ali v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: myalgia myositis, rhabdomyolysis, increased CPK, osteonecrosis (see section 4.4), periarthritis.
Slovenian: mialgija miozitis, rabdomioliza, povišan CPK, osteonekroza (glejte poglavje 4.4), periartritis
English: Excipient with known effect Each 200 mg capsule contains 74.8 mg lactose.
Slovenian: Pomožna snov z znanim učinkom Ena 200 mg kapsula vsebuje 74,8 mg laktoze.
English: Other Anti-infectives Atovaquone
Slovenian: Druga protiinfekcijska zdravila Atovakon
English: In one published study, 20 HIV-infected patients with undetectable plasma viral load (< 200 copies/mL) receiving indinavir 800 mg every 8 hours were switched in an open, cross-over design to indinavir/ritonavir 400/100 mg every 12 hours.
Slovenian: V eni objavljeni študiji so 20 bolnikom, okuženim z virusom HIV in nedoločljivo količino virusa v plazmi (< 200 kopij/ml), ki so prejemali indinavir 800 mg na vsakih 8 ur, odprto, navzkrižno začeli dajati indinavir/ritonavir 400/100 mg na vsakih 12 ur.
English: • delavirdine, efavirenz, nevirapine - used for HIV
Slovenian: • delavirdin, efavirenz, nevirapin - za okužbe s HIV
English: The concomitant use of indinavir with nucleoside analogues (to which the patient is naive) may lessen the risk of the development of resistance to both indinavir and the nucleoside analogues.
Slovenian: Sočasna uporaba indinavirja in nukleozidnih analogov (s katerimi bolniki še niso bili zdravljeni) lahko zmanjša tveganje za razvoj rezistence tako proti indinavirju kot tudi proti nukleozidnim analogom.
English: Lamivudine AUC:  Lamivudine Cmin: 
Slovenian: AUC lamivudina:  Cmin lamivudina: 
English: Indinavir inhibits recombinant HIV-1 and HIV-2 protease with an approximate tenfold selectivity for HIV-1 over HIV-2 proteinase.
Slovenian: Indinavir zavira rekombinantno HIV-1 in HIV-2 proteazo; za prvo je približno desetkrat bolj selektiven kot za drugo.
English: Ritonavir oral solution should not be coadministered with amprenavir oral solution to children due to the risk of toxicity from excipients in the two formulations.
Slovenian: Peroralna raztopina ritonavir in peroralna raztopina amprenavirja se ne smeta sočasno dajati otrokom, saj obstaja tveganje toksičnosti zaradi pomožnih snovi v teh dveh formulacijah.
English: The inducing effect may persist up to 2 weeks after cessation of treatment with St. John's wort.
Slovenian: Induktivni učinek lahko traja do dva tedna po prenehanju jemanja šentjanževke.
English: At week 4, the indinavir Cmin was 500 ng/mL with substantial trough variability (range 5 to 8,100 ng/mL).
Slovenian: V četrtem tednu je bil Cmin indinavirja 500 ng/ml, pri čemer je najmanjša koncentracija pomembno nihala (razpon od 5 do 8100 ng/ml).
English: If you forget to take CRIXIVAN
Slovenian: Če ste pozabili vzeti zdravilo CRIXIVAN
English: Characteristics in patients Pharmacokinetics of indinavir do not appear to be affected by race.
Slovenian: Značilnosti pri bolnikih Ni videti, da bi rasa vplivala na farmakokinetiko indinavirja.
English:  indinavir plasma concentrations may be expected (CYP3A induction).
Slovenian: Pričakujejo se lahko  koncentracije indinavirja v plazmi (indukcija CYP3A).
English: nausea, vomiting, diarrhoea, dyspepsia flatulence, dry mouth, acid regurgitation hepatitis, including reports of hepatic failure, pancreatitis.
Slovenian: navzea, bruhanje, diareja, dispepsija flatulenca, suha usta, refluks kisline hepatitis, vključno s poročili o jetrni odpovedi, pankreatitis
English: Indinavir must not be given with ritonavir to patients with decompensated liver disease as ritonavir is principally metabolized and eliminated by the liver (see section 4.4).
Slovenian: Indinavir se v kombinaciji z ritonavirjem ne sme dajati bolnikom z dekompenzirano jetrno boleznijo, saj se ritonavir večinoma presnavlja in izloča v jetrih (glejte poglavje 4.4).
English: • itraconazole, ketoconazole - used to treat fungal infections
Slovenian: • itrakonazol, ketokonazol - za zdravljenje glivičnih okužb
English: In this open label nonrandomized single arm study, patients were treated with stavudine and lamivudine plus indinavir/ritonavir 400/100 mg every 12 hours.
Slovenian: V tej odprti nerandomizirani študiji z eno skupino so bolnike zdravili s stavudinom in lamivudinom v kombinaciji z indinavirjem/ritonavirjem 400/100 mg na vsakih 12 ur.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki so zdravljeni s kombinirano protiretrovirusno terapijo, obstaja povečano tveganje za resne in potencialno smrtne jetrne neželene učinke.
English: Dose modification of calcium channel blockers should be considered when coadministered with indinavir/ritonavir as it may result in an increased response.
Slovenian: Kadar se blokatorji kalcijevih kanalčkov dajejo sočasno z indinavirjem/ritonavirjem, je treba razmisliti o spremembi njihovega odmerka, saj lahko povečajo odziv.
English: Dose increases of indinavir/ritonavir when given in combination with efavirenz have not been studied.
Slovenian: Povečanja odmerka indinavirja/ritonavirja v kombinaciji z efavirenzom niso preučevali.
English: Zidovudine AUC:  Zidovudine Cmin: ↑ 51 %
Slovenian: AUC zidovudina:  Cmin zidovudina: ↑ 51 %