FrancophonIA/ELRC3.0 huggingface dataset:
English: Results from the main study show that Strimvelis is effective at improving survival of ADA-SCID patients.
Croatian: Rezultati glavnog ispitivanja pokazuju da lijek Strimvelis učinkovito djeluje na povećanje stope preživljavanja bolesnika koji boluju od bolesti ADASCID.
English: Strimvelis can only be obtained with a prescription and treatment should only be given in a specialist transplant centre by a doctor who has experience in the treatment of ADA-SCID and the use of this type of medicine.
Croatian: Lijek Strimvelis izdaje se samo na liječnički recept, a liječenje smije provoditi samo liječnik s iskustvom u liječenju bolesti ADA-SCID i primjeni te vrste lijeka u specijalističkom transplantacijskom centru.
English: Strimvelis is used in patients with ADA-SCID who cannot be treated by a bone-marrow transplant because they do not have a suitable, matched, related donor.
Croatian: Lijek Strimvelis primjenjuje se u bolesnika s bolešću ADA-SCID koje nije moguće liječiti presađivanjem koštane srži jer nemaju pogodnog, podudarnog, srodnog davatelja.
English: Strimvelis contains cells derived from the patient's own bone marrow.
Croatian: Lijek Strimvelis sadrži stanice dobivene iz bolesnikove koštane srži.
English: Strimvelis provides the opportunity of a cure that improves the working of the immune system for patients with ADA-SCID, which is a life-threatening condition.
Croatian: Lijek Strimvelis pruža mogućnost liječenja koje poboljšava djelovanje imunosnog sustava u bolesnika koji boluju od bolesti ADA-SCID koja je opasna po život.
English: For the full list of restrictions and side effects reported with Strimvelis, see the package leaflet.
Croatian: Potpuni popis svih ograničenja i nuspojava zabilježenih pri primjeni lijeka Strimvelis potražite u uputi o lijeku.
English: What benefits of Strimvelis have been shown in studies?
Croatian: Koje su koristi lijeka Strimvelis utvrđene u ispitivanjima?
English: For practical information about using Strimvelis, patients should read the package leaflet or contact their doctor or pharmacist.
Croatian: Praktične informacije o korištenju lijeka Strimvelis pročitajte u uputi o lijeku, odnosno obratite se svom liječniku ili ljekarniku.
English: To make Strimvelis, a sample of the patient's bone marrow is collected.
Croatian: Za pripravljanje lijeka Strimvelis uzima se uzorak koštane srži bolesnika.
English: It must not be used in patients who have tested positive for human immunodeficiency virus (HIV, the virus that causes AIDS) or some other infections, or in patients who have previously had gene therapy treatment.
Croatian: (HIV, virus koji uzrokuje AIDS) ili neke druge infekcije ili u bolesnika koji su prethodno liječeni genskom terapijom.
English: How does Strimvelis work?
Croatian: Kako djeluje Strimvelis?
English: Then, CD34+ cells (cells that can make lymphocytes) are extracted from the bone marrow cells.
Croatian: Zatim se iz stanica koštane srži ekstrahiraju CD34+ stanice (stanice koje mogu proizvoditi limfocite).
English: It is therefore very important that you (or your partner) do not become pregnant during this treatment.
Croatian: Stoga je vrlo važno da Vi (ili Vaša partnerica) ne zatrudnite tijekom liječenja.
English: The potential risk for humans is unknown.
Croatian: Moguć rizik za ljude je nepoznat.
English: None of these effects have been observed in humans.
Croatian: Nijedan od ovih učinaka nije primijećen u ljudi.
English: Ribavirin can harm your unborn baby.
Croatian: Ribavirin može naškoditi nerođenu djetetu.
English: A risk to the newborn/infant cannot be excluded.
Croatian: Ne može se isključiti rizik na novorođenče/dojenče.
English: Do not take a double dose (two doses close together).
Croatian: Nemojte uzeti dvostruku dozu (dvije doze u prekratkom razdoblju).
English: All 4 patients achieved SVR12.
Croatian: Sva 4 bolesnika postigla su SVR12.
English: Keep the tablet blister with you so that you can easily describe what you have taken.
Croatian: Ponesite blister s tabletama sa sobom kako biste mogli s lakoćom opisati što ste uzeli.
English: The studies presented in Table 4 were conducted in healthy adult subjects unless otherwise noted.
Croatian: Ispitivanja prikazana u Tablici 4 provedena su u zdravih odraslih ispitanika, osim ako nije drugačije navedeno.
English: The final study report shall be submitted by:
Croatian: Završno izvješće o ispitivanju treba dostaviti u:
English: Black/African American Other
Croatian: bijela crna/afroamerička druga
English: What Daklinza is and what it is used for
Croatian: Što je Daklinza i za što se koristi
English: Excretion into milk
Croatian: Izlučivanje u mlijeko
English: **GS-331007 is the major circulating metabolite of the prodrug sofosbuvir.
Croatian: **GS-331007 je glavni cirkulirajući metabolit predlijeka sofosbuvira.
English: Ribavirin may be added based on clinical assessment of an individual patient.
Croatian: Ribavirin se može dodati na temelju kliničke ocjene pojedinog bolesnika.
English: End of treatment
Croatian: Kraj liječenja
English: Patients should be instructed to swallow the tablet whole.
Croatian: Bolesnike treba uputiti da tabletu progutaju cijelu.
English: Otherwise the medicine may not work against the hepatitis C virus.
Croatian: U suprotnom, lijek možda neće djelovati protiv virusa hepatitisa C.
English: Other oral contraceptives have not been studied.
Croatian: Drugi oralni kontraceptivi nisu ispitivani.
English: Loc. Fontana del Ceraso 03012 Anagni (FR) Italy
Croatian: Fontana del Ceraso 03012 Anagni (FR) Italija
English: Long term efficacy data
Croatian: Podaci o dugoročnoj djelotvornosti
English: If you have any of these side effects, do not drive or use any tools or machines.
Croatian: Ako imate bilo koju od tih nuspojava, nemojte upravljati vozilom niti raditi sa strojevima.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 August 2014
Croatian: Datum prvog odobrenja: 22. kolovoza 2014.
English: Do not chew or crush the tablet as it has a very unpleasant taste.
Croatian: Tabletu nemojte žvakati niti drobiti jer je jako neugodna okusa.
English: If you take more Daklinza than you should
Croatian: Ako uzmete više lijeka Daklinza nego što ste trebali
English: HORMONAL CONTRACEPTIVES
Croatian: HORMONSKI KONTRACEPTIVI
English: It is important that you continue to take Daklinza during the whole treatment period.
Croatian: Važno je da nastavite uzimati lijek Daklinza tijekom čitavog razdoblja liječenja.
English: See section 4.5.
Croatian: Vidjeti dio 4.5.
English: The lowest dose of digoxin should be initially prescribed.
Croatian: Inicijalno treba propisati najnižu dozu digoksina.
English: Daklinza has not yet been studied in children and adolescents.
Croatian: Daklinza još nije ispitana u djece i adolescenata.
English: Other medicines and Daklinza
Croatian: Drugi lijekovi i Daklinza
English: Daklinza is not recommended for patients below 18 years of age.
Croatian: Daklinza se ne preporučuje za bolesnike mlađe od 18 godina.
English: Regimen and duration HCV GT 1 or 4
Croatian: Režim i trajanje HCV GT 1 ili 4
English: The table is not all-inclusive.
Croatian: Tablica ne uključuje sve.
English: The relevance of adding ribavirin to that regimen is unclear (see section 5.1).
Croatian: Značajnost dodavanja ribavirina tom režimu nije jasna (vidjeti dio 5.1).
English: The absolute bioavailability of the tablet formulation is 67%.
Croatian: Apsolutna bioraspoloživost lijeka u obliku tablete iznosi 67%.
English: Patients who are identified as being at high risk of bradyarrhythmia should be continuously monitored for 48 hours in an appropriate clinical setting.
Croatian: Bolesnike kojima je utvrđen visok rizik od bradiaritmije treba se kontinuirano nadzirati tijekom 48 sati u odgovarajućem kliničkom okruženju.
English: What you need to know before you take Daklinza
Croatian: Što morate znati prije nego počnete uzimati lijek Daklinza
English: This lowers the amount of hepatitis C virus in your body and removes the virus from your blood over a period of time.
Croatian: To smanjuje količinu virusa u tijelu te ga s vremenom uklanja iz krvi.
English: Fibrosis stage F0
Croatian: Stadij fibroze F0
English: Daklinza is sometimes used together with ribavirin.
Croatian: Daklinza se ponekad uzima zajedno s ribavirinom.
English: The active transport is mediated by OCT1 and other unidentified uptake transporters.
Croatian: Aktivni prijenos je posredovan pomoću OCT1 i drugih neidentificiranih transportera preuzimanja.
English: *results are dose-normalised to 60 mg dose.
Croatian: *rezultati su normalizirani za dozu od 60 mg.
English: Not reported CP classes
Croatian: Nije prijavljeno CP stadij
English: * the effect of 60 mg daclatasvir on lopinavir may be higher.
Croatian: * učinak daklatazvira od 60 mg na lopinavir može biti viši
English: It is used to treat adults with hepatitis C, an infectious disease that affects the liver, caused by the hepatitis C virus.
Croatian: Koristi se za liječenje odraslih osoba s hepatitisom C, zaraznom bolesti koja zahvaća jetru, uzrokovanu virusom hepatitisa C.
English: *Compared to historical data.
Croatian: *U usporedbi s podacima iz prethodnih ispitivanja.
English: The relevance of including ribavirin as part of the 24-week regimen is unclear.
Croatian: Značajnost uključivanja ribavirina u 24-tjedni režim liječenja je nejasna.
English: No metabolites circulated at levels more than 5% of the parent concentration.
Croatian: Niti jedan cirkulirajući metabolit nije bio prisutan u koncentraciji većoj od 5% koncentracije osnovnog spoja.
English: Demographic and baseline characteristics of these 50 patients were generally comparable to those for patients who received 12 weeks of study treatment.
Croatian: Demografske i početne značajke tih 50 bolesnika načelno su bile usporedive s onima u bolesnika koji su primili 12 tjedana ispitivane terapije.
English: If you are taking any of these medicines, your doctor may decide to change your daily dose of Daklinza to ensure that the treatment is safe and effective for you.
Croatian: Ako uzimate neki od tih lijekova, liječnik će možda odlučiti promijeniti dnevnu dozu lijeka Daklinza kako bi bio siguran da je liječenje sigurno i djelotvorno.
English: Interaction not studied for this fixed dose combination tablet.
Croatian: Interakcija nije ispitivana za tabletu s ovom fiksnom kombinacijom.
English: The serum digoxin concentrations should be monitored and used for titration of digoxin dose to obtain the desired clinical effect.
Croatian: Koncentracije digoksina u serumu treba nadzirati i na temelju njih titrirati dozu digoksina kako bi se postigao željeni klinički učinak.
English: If you accidentally take more Daklinza tablets than your doctor recommended, contact your doctor at once or contact the nearest hospital for advice.
Croatian: Ako nehotice uzmete više Daklinza tableta nego što Vam je liječnik preporučio, odmah se obratite svom liječniku ili zatražite savjet u najbližoj bolnici.
English: Special populations Elderly
Croatian: Posebne populacije Starije osobe
English: The HCV RNA thresholds that trigger discontinuation of treatment (i.e. treatment stopping rules) are presented in Table 3.
Croatian: Granične vrijednosti HCV RNK koje upućuju na prekid liječenja (tj. pravila prekida liječenja) navedene su u Tablici 3.
English: Because daclatasvir is highly protein bound (99%) and has a molecular weight >500, dialysis is unlikely to significantly reduce plasma concentrations of daclatasvir.
Croatian: Budući da se daklatazvir u velikoj mjeri veže za proteine (99%) i ima molekularnu težinu > 500, nije vjerojatno da bi dijaliza značajno smanjila koncentracije daklatazvira u plazmi.
English: Pharmacotherapeutic group: Direct-acting antiviral, ATC code: J05AX14
Croatian: Farmakoterapijska skupina: antivirusni lijek s izravnim djelovanjem, ATK oznaka: J05AX14
English: Study AI444010
Croatian: Ispitivanje AI444010
English: Study AI444042
Croatian: Ispitivanje AI444042
English: These data indicate that the liver is the major clearance organ for daclatasvir in humans.
Croatian: Ovi podaci pokazuju da je jetra glavni organ za uklanjanje daklatazvira u ljudi.
English: Grade 3 adverse reactions were reported in less than 1% of patients, and no patients had a Grade 4 adverse reaction.
Croatian: Nuspojave 3. stupnja prijavljene su u manje od 1% bolesnika, a nijedan bolesnik nije imao nuspojavu 4. stupnja.
English: If you are pregnant you must not take Daklinza.
Croatian: Ako ste trudni, ne smijete uzimati lijek Daklinza.
English: Treatment of overdose with daclatasvir should consist of general supportive measures, including monitoring of vital signs, and observation of the patient's clinical status.
Croatian: Liječenje predoziranja daklatazvirom treba obuhvaćati opće potporne mjere, uključujući nadzor vitalnih znakova te praćenje kliničkog statusa bolesnika.
English: If you become pregnant, stop taking Daklinza and tell your doctor immediately.
Croatian: Ako zatrudnite, odmah prestanite uzimati lijek Daklinza i obratite se svom liječniku.
English: It is very important that you also read the package leaflets for the other medicines that you will be taking with Daklinza.
Croatian: Vrlo je važno da pročitate i Uputu o lijeku ostalih lijekova koje ćete uzimati s lijekom Daklinza.
English: CCR5 receptor antagonist Maraviroc
Croatian: Antagonist receptora CCR5 maravirok
English: In order to evaluate the recurrence of hepatocellular carcinoma associated with Daklinza, the MAH shall conduct and submit the results of a prospective safety study using data deriving from a cohort of a well-defined group of patients, based on an agreed protocol.
Croatian: Kako bi se procijenilo ponovno pojavljivanje hepatocelularnog karcinoma povezanog s primjenom lijeka Daklinza, nositelj odobrenja mora provesti i dostaviti rezultate prospektivnog ispitivanja sigurnosti, koristeći podatake koji proizlaze iz kohorte dobro definirane skupine bolesnika, na temelju dogovorenog protokola.
English: The duration of your treatment with Daklinza will be either 12 or 24 weeks.
Croatian: Liječenje lijekom Daklinza trajat će 12 ili 24 tjedna.
English: In vitro studies indicate that daclatasvir is actively and passively transported into hepatocytes.
Croatian: In vitro ispitivanja pokazuju da se daklatazvir aktivno i pasivno prenosi u hepatocite.
English: Developmental toxicity consisted of increased embryofoetal lethality, reduced foetal body weights and increased incidence of foetal malformations and variations.
Croatian: Razvojna toksičnost obuhvaćala je povećanu embriofetalnu smrtnost, smanjenu tjelesnu težinu ploda te povećanu incidenciju malformacija i varijacija.
English: Q2 2021
Croatian: 2021. godine
English: No antagonism of antiviral activity was observed.
Croatian: Nisu primijećeni antagonistički učinci na antivirusnu aktivnost.
English: Uxbridge UB8 1DH United Kingdom
Croatian: Uxbridge UB8 1DH Ujedinjeno Kraljevstvo
English: Daclatasvir is an inhibitor of nonstructural protein 5A (NS5A), a multifunctional protein that is an essential component of the HCV replication complex.
Croatian: Daklatazvir je inhibitor nestrukturnog proteina 5A (NS5A), multifunkcionalnog proteina koji je neophodan dio kompleksa za replikaciju HCV-a.
English: Q1, Q3
Croatian: Q1, Q3 min., maks.
English: Daklinza is not recommended for use in children and adolescents aged below 18 years because the safety and efficacy have not been established in this population.
Croatian: Ne preporučuje se primjena lijeka Daklinza u djece i adolescenata mlađih od 18 godina jer sigurnost i djelotvornost u toj populaciji nisu ustanovljene.
English: Fusion inhibitor Enfuvirtide
Croatian: Inhibitor fuzije enfuvirtid
English: Daklinza must be administered in combination with other medicinal products.
Croatian: Daklinza se mora primjenjivati u kombinaciji s drugim lijekovima.
English: HCV Genotype 3 (ALLY-3)
Croatian: HCV genotipa 3 (ALLY-3)
English: NARCOTIC ANALGESICS
Croatian: NARKOTIČKI ANALGETICI
English: 8 weeks therapy
Croatian: 8 tjedana terapije
English: Your doctor may need to adjust the dose of Daklinza or you may not be able to take Daklinza with certain medicines.
Croatian: Vaš liječnik će možda morati prilagoditi dozu lijeka Daklinza ili nećete moći uzimati lijek Daklinza s određenim lijekovima.
English: In phase 1 clinical studies, healthy subjects who received up to 100 mg once daily for up to 14 days or single doses up to 200 mg had no unexpected adverse reactions.
Croatian: kliničkim ispitivanjima faze I, zdravi ispitanici koji su primali do 100 mg jedanput na dan tijekom najdulje 14 dana ili jednokratne doze do najviše 200 mg, nisu imali neočekivanih nuspojava.
English: Table 4 provides information from drug interaction studies with daclatasvir including clinical recommendations for established or potentially significant drug interactions.
Croatian: U Tablici 4 navode se informacije iz ispitivanja interakcija između daklatazvira i drugih lijekova, uključujući kliničke preporuke za utvrđene ili potencijalno značajne interakcije među lijekovima.
English: Daclatasvir is a very weak inducer of CYP3A4 and caused a 13% decrease in midazolam exposure.
Croatian: Daklatazvir je vrlo slab induktor CYP3A4 i uzrokuje smanjenje izloženosti midazolamu od 13%.
English: If you stop taking Daklinza
Croatian: Ako prestanete uzimati lijek Daklinza
English: Resistance in clinical studies
Croatian: Rezistencija u kliničkim ispitivanjima
English: Embryo-foetal development
Croatian: Embriofetalni razvoj
English: Etravirine Nevirapine
Croatian: etravirin nevirapin
English: The European Medicines Agency has deferred the obligation to submit the results of studies with daclatasvir in one or more subsets of the paediatric population in the treatment of chronic hepatitis C (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je odgodila obvezu podnošenja rezultata ispitivanja daklatazvira u jednoj ili više podskupina pedijatrijske populacije za liječenje kroničnog hepatitisa C (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: The mean score on the FibroTest (a validated non-invasive diagnostic assay) was 0.460 (range: 0.03 to 0.89).
Croatian: Srednja vrijednost rezultata na FibroTestu (validiran i neinvazivan dijagnostički test) iznosila je 0,460 (raspon: 0,03 do 0,89).
English: There is limited experience of accidental overdose of daclatasvir in clinical studies.
Croatian: Ograničena su iskustva sa slučajnim predoziranjem daklatazvirom u kliničkim ispitivanjima.
English: This regimen is an alternative recommended regimen for patients with genotype 4 infection, without cirrhosis or with compensated cirrhosis.
Croatian: Ovo je alternativni preporučeni režim za bolesnike s infekcijom genotipom 4, bez ciroze ili s kompenziranom cirozom.
English: Blood and lymphatic system disorders very common anaemia
Croatian: Poremećaji krvi i limfnog sustava vrlo često anemija
English: Follow guidelines above for haemoglobin
Croatian: Slijediti gore navedene smjernice za hemoglobin
English: Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to ribavirin; therefore, extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients (see the Summary of Product Characteristics for ribavirin).
Croatian: U svih životinjskih vrsta izloženih ribavirinu primijećeni su značajni teratogeni i/ili embriocidni učinci; stoga je potrebno strogo paziti da se izbjegne trudnoća u bolesnica i partnerica bolesnika (vidjeti Sažetak opisa svojstava lijeka za ribavirin).
English: Daclatasvir Cmax, AUC, and Cmin increased in a near dose-proportional manner.
Croatian: Cmax, AUC, i Cmin daklatazvira povećavali su se gotovo proporcionalno dozi.
English: Genotype 1a Genotype 1b Genotype 2 Genotype 3 N=301
Croatian: Genotip 1a Genotip 1b Genotip 2 Genotip 3 N=301
English: ↔ Ethinylestradiol
Croatian: ↔ etinilestradiol
English: Clinically relevant increase in concentration is indicated as “↑”, clinically relevant decrease as “↓”, no clinically relevant change as “↔”.
Croatian: Klinički značajan porast koncentracije označen je kao “↑”, klinički značajan pad kao “↓”, a stanje bez klinički značajne promjene kao “↔”.
English: All Genotype 3 N=18
Croatian: svi s genotipom 3 N=18
English: Refer to section 4.3 for a listing of medicinal products that are contraindicated for use with Daklinza due to potential loss of therapeutic effect.
Croatian: Vidjeti dio 4.3 za popis lijekova čija je istodobna primjena s lijekom Daklinza kontraindicirana zbog mogućeg gubitka terapijskog učinka.
English: Mothers should be instructed not to breastfeed if they are taking Daklinza.
Croatian: Majkama treba napomenuti da ne smiju dojiti ako uzimaju lijek Daklinza.
English: Age (years): median (range) Race:
Croatian: Dob (godine): medijan (raspon)
English: Studies of daclatasvir in animals have shown embryotoxic and teratogenic effects (see section 5.3).
Croatian: Ispitivanja daklatazvira na životinjama ukazala su na embriotoksične i teratogene učinke (vidjeti dio 5.3).
English: Important information about some of the ingredients in Daklinza Daklinza contains lactose.
Croatian: Važne informacije o nekim sastojcima lijeka Daklinza Daklinza sadrži laktozu.
English: Patients with Child-Pugh C liver disease
Croatian: Bolesnici s bolešću jetre Child-Pugh stadija C
English: Psychiatric disorders common insomnia, irritability insomnia
Croatian: Psihijatrijski poremećaji često nesanica, razdražljivost nesanica
English: Limited data are available from an ongoing follow-up study to assess durability of response up to 3 years after treatment with daclatasvir.
Croatian: Dostupni su malobrojni podaci iz ispitivanja praćenja koje je u tijeku, a u kojem se ocjenjuje postojanost odgovora do 3 godine nakon liječenja daklatazvirom.
English: However, as this is a limited effect, dose adjustment of concomitantly administered CYP3A4 substrates is not necessary.
Croatian: No s tim ograničenim učinkom, prilagodba doze istodobno primijenjenog supstrata CYP3A4 nije potrebna.
English: In genotype 4, amino acid substitutions at 30 and 93 (EC50 < 16 nM) were frequently selected.
Croatian: Kod genotipa 4 često su se izdvajale aminokiselinske supstitucije na položajima 30 i 93 (EC50 < 16 nM).
English: Daklinza must always be used together with other medicines against hepatitis C infection and must never be used by itself.
Croatian: Daklinza se uvijek mora uzimati zajedno s drugim lijekovima protiv infekcije hepatitisom C i nikada se ne smije uzimati samostalno.
English: The patient with virologic breakthrough met the original protocol definition of confirmed HCV RNA <LLOQ, detectable at treatment Week 8.
Croatian: Bolesnik s virološkim probojem zadovoljio je izvornu protokolarnu definiciju potvrđene razine HCV RNK < LLOQ, koja je bila mjerljiva u 8. tjednu liječenja.
English: SVR12 was achieved by 74% of patients in this study (genotype 1a: 70%, genotype 1b: 79%).
Croatian: SVR12 je postignut kod 74% bolesnika u ovom ispitivanju (genotip 1a: 70%, genotip1b: 79%).
English: Amiodarone
Croatian: Amiodaron
English: If available, ratios of geometric means are shown, with 90% confidence intervals (CI) in parentheses.
Croatian: Ondje gdje su dostupni, prikazani su i omjeri geometrijskih srednjih vrijednosti, uz intervale pouzdanosti (engl. confidence interval, CI) od 90% navedene u zagradama.
English: Very common (may affect more than 1 in 10 people): headache, fatigue
Croatian: Vrlo često (mogu se javiti u više od 1 na 10 osoba): glavobolja, umor
English: For patients with Child-Pugh A, B, or C cirrhosis or recurrence of HCV infection after liver transplantation, the recommended initial dose of ribavirin is 600 mg daily with food.
Croatian: Za bolesnike s cirozom Child-Pugh stadija A, B ili C ili povratom infekcije HCV-om nakon presađivanja jetre, preporučena početna doza ribavirina iznosi 600 mg na dan, a uzima se s hranom.
English: This is because Daklinza may affect the way some medicines work.
Croatian: To je stoga što Daklinza može utjecati na način kako djeluju neki lijekovi.
English: Daclatasvir in vitro did not inhibit (IC50 >40 µM) CYP enzymes 1A2, 2B6, 2C8, 2C9, 2C19, or 2D6.
Croatian: Daklatazvir nije inhibirao (IC50 > 40 µM) enzime CYP1A2, 2B6, 2C8, 2C9, 2C19 ni 2D6 in vitro.