FrancophonIA/ELRC3.0 huggingface dataset:
English: ringing sound in your ears uncommon:
Slovenian: zvonjenje v ušesih občasni:
English: That contention is also supported by a greater number of patients who need rescue therapy switching from ciclosporin to tacrolimus than the other way around.
Slovenian: To trditev podpira tudi večje število bolnikov, ki so morali nujno preiti z zdravljenja s ciklosporinom na zdravljenje s takrolimusom, v primerjavi s številom tistih, ki so potrebovali zamenjavo v obratni smeri.
English: In general, paediatric patients require doses 1½ - 2 times higher than the adult doses to achieve similar blood levels.
Slovenian: Pri pediatričnih bolnikih so za doseganje podobnih koncentracij v krvi kot pri odraslih na splošno potrebni 1,5- do 2-krat večji odmerki, kot so odmerki za odrasle.
English: Stevens Johnson syndrome Musculoskeletal and connective tissue disorders common:
Slovenian: Stevens-Johnsonov sindrom Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti:
English: If abnormalities develop, dose reduction of <Invented name> therapy, or change of treatment to another immunosuppressive agent should be considered.
Slovenian: Če se pojavijo nenormalnosti, je treba razmisliti o zmanjšanju odmerka <(Lastniško) ime zdravila> ali o prehodu na drugo imunosupresivno zdravilo.
English: In rats, female reproductive function including birth was impaired at toxic dosages and the offspring showed reduced birth weights, viability and growth.
Slovenian: Pri podganah je bila reprodukcijska funkcija samic, vključno s kotenjem, okvarjena pri toksičnih odmerkih, pri mladičih pa so ugotovili manjšo telesno maso ob skotitvi, manjšo viabilnost in počasnejšo rast.
English: Monitoring of ciclosporin blood levels should be continued following conversion as the clearance of ciclosporin might be affected.
Slovenian: Koncentracijo ciklosporina v krvi je treba nadzirati tudi še po prehodu, ker se očistek ciklosporina lahko upočasni.
English: The clinical trials conducted in indications other than liver and kidney transplantation have been quite small and seem to have been investigator driven rather then driven by the MAH.
Slovenian: Klinična preskušanja, izvedena v zvezi z indikacijami, ki ne zadevajo presaditve ledvic in jeter, so precej majhnega obsega in kaže, da so bile v večji meri vzpodbujena s strani preiskovalcev in ne toliko s strani imetnika dovoljenja za promet z zdravilom.
English: In adult liver, kidney and heart transplant patients, values of 4.1 l/h, 6.7 l/h and 3.9 l/h, respectively, have been observed.
Slovenian: Pri odraslih bolnikih s presajenimi jetri so ugotovili vrednost 4,1 l/uro, ledvicami 6,7 l/uro in srcem 3,9 l/uro.
English: In a study of stable renal transplant patients who were administered <Invented name> immediately after a standard continental breakfast the effect on oral bioavailability was less pronounced.
Slovenian: V študiji stabilnih bolnikov po presaditvi ledvice, ki so zaužili <Invented name> tik po običajnem zajtrku, je bil učinek na peroralno biološko uporabnost manj izrazit.
English: As with other immunosuppressive agents, owing to the potential risk of malignant skin changes, exposure to sunlight and UV light should be limited by wearing protective clothing and using a sunscreen with a high protection factor.
Slovenian: Enako kot pri drugih imunosupresivnih sredstvih obstaja potencialno tveganje za maligne kožne spremembe, zato je treba izpostavljenost sončni in ultravijolični svetlobi omejiti: bolnik naj nosi oblačila, ki varujejo, in naj uporablja sredstvo za sončenje z visokim zaščitnim faktorjem.
English: It is therefore recommended to monitor tacrolimus blood levels whenever substances which have the potential to alter CYP3A metabolism are used concomitantly and to adjust the tacrolimus dose as appropriate in order to maintain similar tacrolimus exposure (see sections 4.2 and 4.4).
Slovenian: Zato je koncentracijo takrolimusa v krvi priporočljivo nadzirati, kadarkoli sočasno uporabljate učinkovine, ki lahko spremenijo presnovo CYP3A, in odmerek takrolimusa ustrezno prilagoditi, da bi izpostavljenost takrolimusu ohranili približno enako (glejte poglavji 4.2 in 4.4).
English: Tacrolimus is also considerably metabolised in the intestinal wall.
Slovenian: V precejšnji meri se presnovi tudi v črevesni steni.
English: [To be implemented nationally] <<Invented name> 5 mg/ml Concentrate for Solution for Infusion contains polyoxyethylene hydrogenated castor oil, which has been reported to cause anaphylactoid reactions.
Slovenian: [Izvrši država članica] <<Lastniško ime> 5 mg/1 ml koncentrat za raztopino za infundiranje vsebuje polioksietilen hidrogenirano ricinusovo olje, za katero je opisano, da povzroča anafilaktoidne reakcije.
English: The 1-year patient survival was 83% in the tacrolimus and 71% in the ciclosporin group, the 2-year survival rates were 76% and 66%, respectively.
Slovenian: Enoletno preživetje v skupini s takrolimusom je bilo 83 % in v skupini s ciklosporinom 71 %, dveletno pa v prvi 76 % in v drugi 66 %.
English: Astellas Pharma Ges.m.b.H.
Slovenian: Astellas Pharma Ges.m.b.H Linzerstr.
English: hepatitic artery thrombosis, venoocclusive liver disease very rare:
Slovenian: tromboza jetrne arterije, venookluzivna bolezen jeter zelo redki:
English: tremor, headache common:
Slovenian: tremor, glavobol pogosti:
English: Pancreas transplantation
Slovenian: Presaditev pankreasa
English: <Invented name> is excreted into breast milk.
Slovenian: <(Lastniško) ime zdravila> se izloča v materinem mleku.
English: blindness
Slovenian: slepota
English: Do not use <Invented name> - If you are allergic (hypersensitive) to tacrolimus or to any antibiotic belonging to the subgroup of macrolide antibiotics.
Slovenian: Ne uporabljajte zdravila <(Lastniško) ime zdravila> - Če ste alergični na (preobčutljivi za) takrolimus ali katerikoli antibiotik iz podskupine makrolidnih antibiotikov.
English: [Method of administration to be completed nationally] Read the package leaflet before use.
Slovenian: [Pot uporabe zdravila izpolni država članica] Pred uporabo preberite priloženo navodilo.
English: Mechanism of action and pharmacodynamic effects At the molecular level, the effects of tacrolimus appear to be mediated by binding to a cytosolic protein (FKBP12) which is responsible for the intracellular accumulation of the compound.
Slovenian: Kaže, da učinek takrolimusa na molekulski ravni posreduje vezava na citosolno beljakovino (FKBP12), ki je odgovorna za njegovo znotrajcelično kopičenje.
English: Other factors observed to increase the risk of these clinical conditions included pre-existing heart disease, corticosteroid usage, hypertension, renal or hepatic dysfunction, infections, fluid overload, and oedema.
Slovenian: Drugi dejavniki, za katere je ugotovljeno, da povečujejo tveganje za te klinične motnje, so obstoječa bolezen srca, jemanje kortikosteroidov, hipertenzija, moteno delovanje ledvic ali jeter, okužbe, preobremenitev s tekočino in edemi.
English: The adverse drug reaction profile associated with immunosuppressive agents is often difficult to establish owing to the underlying disease and the concurrent use of multiple medications.
Slovenian: Značilnosti v zvezi z neželenimi reakcijami na zdravilo je pri imunosupresivih pogosto težko ugotoviti zaradi osnovne bolezni in sočasne uporabe več zdravil.
English: hypertension common:
Slovenian: hipertenzija pogosti:
English: bleeding, partial or complete blocking of blood vessels, reduced blood pressure uncommon:
Slovenian: krvavitve, delna ali popolna zapora žil, znižan krvni tlak občasni:
English: The dose recommendations for lung, pancreas and intestinal transplantation are based on limited prospective clinical trial data.
Slovenian: Priporočeni odmerki pri presaditvah pljuč, pankreasa in črevesa temeljijo na omejenih podatkih prospektivnih kliničnih preskušanj.
English: Tacrolimus affected male fertility in rats (see section 5.3).
Slovenian: Pri podganah je takrolimus prizadel plodnost samcev (glejte poglavje 5.3).
English: <Invented name> can be administered intravenously or orally.
Slovenian: <(Lastniško) ime zdravila> je mogoče uporabljati intravensko ali peroralno.
English: anuria, haemolytic uraemic syndrome very rare:
Slovenian: anurija, hemolitično-uremični sindrom zelo redki:
English: In an additional two-centre study, 26 patients were randomised to the tacrolimus versus 24 patients to the ciclosporin group.
Slovenian: V dodatni študiji v dveh centrih so 26 bolnikov randomizirali na takrolimus in 24 na ciklosporin.
English: Effect of tacrolimus on the metabolism of other medicinal products Tacrolimus is a known CYP3A4 inhibitor; thus concomitant use of tacrolimus with medicinal products known to be metabolised by CYP3A4 may affect the metabolism of such medicinal products.
Slovenian: Takrolimus je znan zaviralec CYP3A4, zato lahko njegova sočasna uporaba z zdravili, ki se presnavljajo s CYP3A4, vpliva na presnovo takšnih zdravil.
English: Only one of these has been shown in vitro to have immunosuppressive activity similar to that of tacrolimus.
Slovenian: Le za enega od njih so in vitro ugotovili, da deluje podobno imunosupresijsko kot takrolimus.
English: There is consistent evidence across many small and some moderate sized clinical trials that tacrolimus is an effective maintenance immunosuppressant when used as part of a multi-agent regimen.
Slovenian: Obstajajo dosledni dokazi iz številnih majhnih in srednje velikih kliničnih preskušanj, ki kažejo, da je takrolimus, uporabljen v kombinacijami z drugimi učinkovinami, učinkovit vzdrževalni imunosupresiv.
English: In current clinical practice, whole blood levels are monitored using immunoassay methods.
Slovenian: V klinični praksi se za nadziranje koncentracije v polni krvi trenutno uporabljajo metode imunskega preizkusa.
English: In vitro the following substances have been shown to be potential inhibitors of tacrolimus metabolism: bromocriptine, cortisone, dapsone, ergotamine, gestodene, lidocaine, mephenytoin, miconazole, midazolam, nilvadipine, norethindrone, quinidine, tamoxifen, (triacetyl)oleandomycin.
Slovenian: In vitro so se kot možni zaviralci presnove takrolimusa izkazale naslednje snovi: bromokriptin, kortizon, dapson, ergotamin, gestoden, lidokain, mefenitoin, mikonazol, midazolam, nilvadipin, noretindron, kinidin, tamoksifen, (triacetil)oleandomicin.
English: Very young (< 2 years), EBV-VCA-negative children have been reported to have an increased risk of developing lymphoproliferative disorders.
Slovenian: Opisano je, da limfoproliferativne bolezni bolj ogrožajo zelo mlade (< 2 leti), EBV-VCA-negativne otroke.
English: - The alcohol content (638 mg per ml) of <Invented name> 5mg/ml Concentrate for Infusion should be taken into account.
Slovenian: - Upoštevati je treba vsebnost alkohola (638 mg na ml) v koncentratu za raztopino za infundiranje <(Lastniško) ime zdravila> 5 mg/ml.
English: [See Annex I - to be completed nationally] Tacrolimus
Slovenian: [Glejte Dodatek I - Izpolni država članica] Takrolimus
English: This effect may be enhanced if <Invented name> is administered in association with alcohol.
Slovenian: Ta učinek se lahko stopnjuje, če je <(Lastniško) ime zdravila> uporabljen skupaj z alkoholom.
English: Endocrine disorders rare:
Slovenian: Bolezni endokrinega sistema redki:
English: Hypersensitivity to any of the excipients <To be implemented nationally - in particular polyoxyethylene hydrogenated castor oil or structurally related compounds.>
Slovenian: Preobčutljivost za katerokoli pomožno snov <Izvrši država članica - zlasti pri polioksietilen hidrogeniranem ricinusovem olju ali strukturno podobnih snoveh.>
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORMS, STRENGTHS OF THE MEDICINAL PRODUCT, ROUTES OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
Slovenian: DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, <PREDLAGATELJEV>, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH TER NORVEŠKA IN ISLANDIJA
English: Treatment of allograft rejection resistant to treatment with other immunosuppressive medicinal products.
Slovenian: Zdravljenje zavrnitve alotransplantata, odporne proti terapiji z drugimi imunosupresivi.
English: <Invented name> is used to control your body's immune response enabling your body to accept the transplanted organ.
Slovenian: <(Lastniško) ime zdravila> uporabljamo za obvladovanje telesnega imunskega odziva, kar omogoči, da telo sprejme presajeni organ.
English: - If you are allergic (hypersensitive) to any of the other ingredients <To be implemented nationally - in particular polyoxyethylene hydrogenated castor oil or similar substances.>
Slovenian: - Če ste alergični na (preobčutljivi za) katerokoli pomožno snov zdravila <Izvrši država članica zlasti pri polioksietilen hidrogeniranem ricinusovem olju in strukturno podobnih snoveh>.
English: Available data suggests that the pharmacokinetics of statins are largely unaltered by the co-administration of tacrolimus.
Slovenian: Podatki, ki so na voljo, kažejo, da sočasna uporaba takrolimusa v glavnem ne spremeni farmakokinetike statinov.
English: As is well known for other potent immunosuppressive agents, patients receiving tacrolimus are frequently at increased risk for infections (viral, bacterial, fungal, protozoal).
Slovenian: Tako kot med zdravljenjem z drugimi močnimi imunosupresivi bolnike tudi med zdravljenjem s takrolimusom pogosto bolj ogrožajo okužbe (virusne, bakterijske, glivične, praživalske).
English: In isolated patients with very high plasma levels, haemofiltration or -diafiltration have been effective in reducing toxic concentrations.
Slovenian: Pri posameznih bolnikih z zelo veliko koncentracijo v plazmi sta toksične koncentracije učinkovito zmanjšali hemofiltracija ali hemodiafiltracija.
English: Subsequently, during maintenance therapy, blood concentrations have generally been in the range of 5 - 15 ng/ml in liver, kidney and heart transplant recipients.
Slovenian: Pozneje, med vzdrževalnim zdravljenjem, so bile koncentracije v krvi pri prejemnikih jeter, ledvic ali srca na splošno od 5 do 15 ng/ml.
English: Other interactions which have led to clinically detrimental effects Concurrent use of tacrolimus with medicinal products known to have nephrotoxic or neurotoxic effects may increase these effects (e.g., aminoglycosides, gyrase inhibitors, vancomycin, cotrimoxazole, NSAIDs, ganciclovir or aciclovir).
Slovenian: Druge interakcije, ki so povzročile klinično škodljive učinke Te učinke lahko poveča sočasna uporaba takrolimusa in zdravil z nefrotoksičnimi ali nevrotoksičnimi učinki (kot so npr. aminoglikozidi, zaviralci giraze, vankomicin, kotrimoksazol, nesteroidni antirevmatiki, ganciklovir ali aciklovir).
English: Clinically the following substances have been shown to increase tacrolimus blood levels: Strong interactions have been observed with antifungal agents such as ketoconazole, fluconazole, itraconazole and voriconazole, the macrolide antibiotic erythromycin or HIV protease inhibitors (e.g. ritonavir).
Slovenian: Klinično je ugotovljeno, da koncentracijo takrolimusa v krvi povečujejo naslednje snovi: Močne interakcije so opažali z antimikotiki, kot so ketokonazol, flukonazol, itrakonazol in vorikonazol, makrolidnim antibiotikom eritromicinom in zaviralci proteaz HIV (npr. ritonavirjem).
English: Systemically available tacrolimus is metabolised by hepatic CYP3A4.
Slovenian: Presnova sistemsko razpoložljivega takrolimusa poteka z jetrnim CYP3A4.
English: It is recommended that the oral daily dose be administered in two divided doses (e.g. morning and evening).
Slovenian: Peroralni dnevni odmerek je priporočljivo uporabiti v dveh deljenih odmerkih (npr. zjutraj in zvečer).
English: Hypersensitivity to any of the excipients.
Slovenian: Preobčutljivost za katerokoli pomožno snov.
English: reduction in blood cell counts (platelets, red or white blood cells), increase in white blood cell counts, changes in red blood cell counts uncommon:
Slovenian: zmanjšanje števila krvnih celic (trombocitov, rdečih ali belih krvnih celic), povečanje števila belih krvnih celic, spremembe števila rdečih krvnih celic občasni:
English: Important information about some of the ingredients of <Invented name> - <Invented name> contains polyoxyethylene hydrogenated castor oil that may, in a small number of patients, lead to a severe allergic reaction.
Slovenian: - <(Lastniško) ime zdravila> vsebuje polioksietilen hidrogenirano ricinusovo olje, ki lahko pri majhnem številu bolnikov povzroči hudo alergijsko reakcijo.
English: cataract rare:
Slovenian: katarakta redki:
English: PHARMACEUTICAL FORM [To be completed nationally]
Slovenian: FARMACEVTSKA OBLIKA [Izpolni država članica]
English: Prograf 5 mg Capsules
Slovenian: PRETISNI OMOT 5 mg KAPSULE
English: collection of fluid around the heart very rare:
Slovenian: kopičenje tekočine okrog srca zelo redki:
English: You should generally take <Invented name> on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal.
Slovenian: Jemanje zdravila <(Lastniško) ime zdravila> skupaj s hrano in pijačo Praviloma morate <(Lastniško) ime zdravila> vzeti na prazen želodec oz. vsaj 1 uro pred jedjo ali 2 do 3 ure po jedi.
English: GROUNDS FOR AMENDMENT OF THE SUMMARY(IES) OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET
Slovenian: PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJA IN NAVODILO ZA UPORABO
English: <Invented name> reduces your body's own defense mechanism to stop you rejecting your transplanted organ.
Slovenian: <(Lastniško) ime zdravila> zavira obrambni mehanizem telesa in tako prepreči zavrnitev presajenega organa.
English: Patients treated with <Invented name> have been reported to develop EBV-associated lymphoproliferative disorders.
Slovenian: Med zdravljenjem s <(Lastniško) ime zdravila> je opisan pojav z EBV povezanih limfoproliferativnih bolezni.
English: Pharma Swiss d.o.o.
Slovenian: PharmaSwiss d.o.o.
English: increased blood sugar, diabetes mellitus, increased potassium in the blood common:
Slovenian: zvišan krvni sladkor, diabetes mellitus, zvišanje kalija v krvi pogosti:
English: This has been done mainly by long time experience with the drug at different centres in Europe and the US. Data from “The Registry of the International Society for Heart and Lung Transplantation” (ISHLT) confirm the findings of the MAH's pivotal study in primary heart transplantation as well as the results of an array of small, single centre, open, randomized/nonrandomized studies.
Slovenian: Podatki iz »Registra Mednarodnega združenja za presaditve srca in pljuč (ISHLT)« potrjujejo ugotovitve osrednje raziskave, ki jo je izvedel imetnik dovoljenja za promet z zdravilom v zvezi z primarno presaditvijo srca, kakor tudi rezultate iz nabora manjših, enocentričnih, odprtih randomiziranih/nerandomiziranih raziskav.
English: Whilst you are receiving <Invented name> your doctor may want to carry out a number of tests (including blood, urine, heart function, visual and neurological tests) from time to time.
Slovenian: - Med jemanjem <(Lastniško) ime zdravila> vam bo zdravnik od časa do časa naredil različne preiskave (vključno s preiskavami krvi, urina, vida, delovanja srca in nevrološkimi preiskavami).
English: hearing impaired
Slovenian: okvara sluha
English: High dose prednisolone or methylprednisolone administered for the treatment of acute rejection have the potential to increase or decrease tacrolimus blood levels.
Slovenian: Veliki odmerki prednizolona ali metilprednizolona, uporabljeni za zdravljenje akutne zavrnitve, lahko koncentracijo takrolimusa v krvi zvišajo ali znižajo.
English: Possible interactions with other medicinal products known to have high affinity for plasma proteins should be considered (e.g., NSAIDs, oral anticoagulants, or oral antidiabetics).
Slovenian: Upoštevati je treba možnost medsebojnega delovanja z drugimi zdravili, ki imajo veliko afiniteto za beljakovine v plazmi (npr. nesteroidna protivnetna zdravila, peroralni antikoagulanti ali peroralni antidiabetiki).
English: dehydration, hypoproteinaemia, hyperphosphataemia, hypoglycaemia Psychiatric disorders very common:
Slovenian: dehidracija, hipoproteinemija, hiperfosfatemija, hipoglikemija Psihiatrične motnje zelo pogosti:
English: After reconstitution: [To be completed nationally]
Slovenian: Po pripravi: [Izpolni država članica]
English: In healthy subjects, <Invented name> 0.5 mg, <Invented name> 1 mg and <Invented name> 5 mg Capsules, hard have been shown to be bioequivalent, when administered as equivalent dose.
Slovenian: Pri zdravih preiskovancih so 0,5-mg, 1-mg in 5-mg trde kapsule <(Lastniško) ime zdravila> dokazano bioekvivalentne, če so uporabljene v ekvivalentnih odmerkih.
English: Therefore you may be more prone to infections than usual while you are taking <Invented name>.
Slovenian: Zato se lahko zgodi, da ste med jemanjem <(Lastniško) ime zdravila> bolj nagnjeni k okužbam kot običajno.
English: insufficient function of the kidneys, reduced production of urine, impaired or painful urination uncommon:
Slovenian: nezadostno delovanje ledvic, zmanjšano nastajanje urina, motnje uriniranja ali boleče uriniranje občasni:
English: Hard Capsules
Slovenian: Kapsula, trda
English: In lung-transplanted patients <Invented name> has been used at an initial oral dose of 0.10 - 0.15 mg/kg/day, in pancreas-transplanted patients at an initial oral dose of 0.2 mg/kg/day and in intestinal transplantation at an initial oral dose of 0.3 mg/kg/day.
Slovenian: Pri bolnikih po presaditvi pljuč so <(Lastniško) ime zdravila> uporabljali v začetnem peroralnem odmerku od 0,10 do 0,15 mg/kg/dan, po presaditvi pankreasa v začetnem peroralnem odmerku 0,2 mg/kg/dan in po presaditvi črevesa v začetnem peroralnem odmerku 0,3 mg/kg/dan.
English: small bleedings in your skin due to blood clots Metabolism and nutrition disorders very common:
Slovenian: drobne krvavitve v kožo kot posledica krvnih strdkov Presnovne in prehranske motnje zelo pogosti:
English: increase of fat tissue Disorders of your transplanted organ common:
Slovenian: povečanje maščobnega tkiva Bolezni presajenega organa pogosti:
English: Care should be taken when converting patients from ciclosporin-based to <Invented name>-based therapy (see sections 4.4 and 4.5).
Slovenian: Pri prehodu s ciklosporinskega zdravljenja na zdravljenje s <(Lastniško) ime zdravila> je potrebna previdnost (glejte poglavji 4.4 in 4.5).
English: EXPIRY DATE EXP: {MM/YYYY}
Slovenian: DATUM IZTEKA ROKA UPORABNOSTI ZDRAVILA EXP: {MM/LLLL}
English: - Please avoid taking any herbal remedies, e.g. St. John's wort (Hypericum perforatum) or any other herbal products as this may affect the effectiveness and the dose of <Invented name> that you need to receive.
Slovenian: - Ne jemljite nobenih zdravil rastlinskega izvora, npr. šentjanževke (Hypericum perforatum), in nobenih drugih izdelkov rastlinskega izvora, ker lahko vplivajo na učinkovitost in odmerek <(Lastniško) ime zdravila>, ki ga morate dobivati.
English: In man tacrolimus has been shown to be able to be absorbed throughout the gastrointestinal tract.
Slovenian: Pri človeku je dokazano, da se takrolimus absorbira skozi celotna prebavila.
English: A variety of innovations, such as techniques for early detection of Epstein-Barr (EBV) and CMV infections, bone marrow augmentation, the adjunct use of the interleukin-2 antagonist daclizumab, lower initial tacrolimus doses with target trough levels of 10 to 15 ng/ml, and most recently allograft irradiation were considered to have contributed to improved results in this indication over time (AbuElmagd et al., Ann Surg 2001;234:404).
Slovenian: Domnevno so k izboljšanju rezultatov skozi čas pri tej indikaciji pripomogle različne inovacije, npr. postopki za zgodnje odkrivanje okužb z virusom Epstein-Barr (EBV) in CMV, prirast kostnega mozga, dodatna uporaba antagonista interlevkina-2 daklizumaba, nižji začetni odmerki takrolimusa s ciljno najnižjo koncentracijo od 10 do 15 ng/ml in, v najnovejšem času, obsevanje alotransplantata (Abu-Elmagd et al., Ann Surg
English: Duration of dosing
Slovenian: Trajanje odmerjanja