FrancophonIA/ELRC3.0 huggingface dataset:
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor, nurse or pharmacist for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku, medicinskoj sestri ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: Other medicines and Rubraca
Croatian: Drugi lijekovi i Rubraca
English: The safety and efficacy of Rubraca in children or adolescents aged less than 18 years have not been established.
Croatian: Pedijatrijska populacija Sigurnost i djelotvornost lijeka Rubraca u djece ili adolescenata u dobi mlađoj od 18 godina nije ustanovljena.
English: Detection of BRCA mutation
Croatian: Otkrivanje BRCA mutacije
English: Investigator Assessment
Croatian: Procjena ispitivača
English: Do not use this medicine after the expiry date which is stated on the bottle and the carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na boci i kutiji iza oznake EXP.
English: Treatment with rucaparib should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.
Croatian: Liječenje lijekom rukaparib treba započeti i nadgledati liječnik koji je iskusan u primjeni lijekova protiv raka.
English: A risk to the newborns/infants cannot be excluded.
Croatian: Rizik po novorođenčad/dojenčad ne može se isključiti.
English: What Rubraca looks like and contents of the pack
Croatian: Kako Rubraca izgleda i sadržaj pakiranja
English: Patients should avoid spending time in direct sunlight because they may burn more easily during rucaparib treatment; when outdoors, patients should wear a hat and protective clothing, and use sunscreen and lip balm with sun protection factor (SPF) of 50 or greater.
Croatian: Bolesnice trebaju izbjegavati boravljenje na izravnoj sunčevoj svjetlosti jer mogu lakše dobiti opekline tijekom liječenja rukaparibom; kada su vani, bolesnice trebaju nositi šešir i zaštitnu odjeću te koristiti kremu za sunčanje i balzam za usne sa zaštitnim faktorom (SPF) 50 ili višim.
English: In repeat-dose toxicity studies of up to 3 months duration in rats and dogs, the target organs were the gastrointestinal, haematopoietic, and lymphopoietic systems.
Croatian: U ispitivanjima toksičnosti ponovljene doze u trajanju do 3 mjeseca na štakorima i psima, ciljni organi bili su gastrointestinalni, hematopoetski i limfopoetski sustavi.
English: The recommended dose is 600 mg rucaparib taken twice daily, equivalent to a total daily dose of 1,200 mg, until disease progression or unacceptable toxicity.
Croatian: Preporučena doza je 600 mg rukapariba dva puta dnevno, što odgovara ukupnoj dnevnoj dozi od 1200 mg, sve do progresije bolesti ili neprihvatljive toksičnosti.
English: Patients were randomised within 8 weeks of completion of platinum chemotherapy and no intervening maintenance treatment was permitted.
Croatian: Pacijentice su randomizirane unutar 8 tjedana nakon završetka kemoterapije na bazi platine i nije bila dozvoljena intervencijska terapija održavanja.
English: In vitro, M324 was at least 30 fold less potent than rucaparib against PARP-1, PARP-2, and PARP-3.
Croatian: In vitro, M324 je bio najmanje 30 puta manje snažan od rukapariba protiv PARP-1, PARP-2 i PARP-3.
English: Dose adjustments may be considered, if clinically indicated based on observed adverse reactions.
Croatian: Mogu se razmotriti prilagodbe doze ako je klinički indicirano na temelju uočenih nuspojava.
English: Frequency of all CTCAE grades Frequency of CTCAE grade 3 and above
Croatian: Učestalost svih CTCAE stupnjeva Učestalost CTCAE 3. stupnja ili više
English: Tell your doctor, pharmacist or nurse if you are taking, have recently taken, or might take any other medicines.
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: Decreased appetite, Dehydration
Croatian: Često smanjen apetit, dehidracija
English: The in vitro protein binding of rucaparib is 70.2% in human plasma at therapeutic concentration levels.
Croatian: Vezanje rukapariba za proteine in vitro iznosi 70,2 % u ljudskoj plazmi pri terapijskim koncentracijama.
English: Maintenance treatment of recurrent ovarian cancer
Croatian: Terapija održavanja za recidivirajući rak jajnika
English: No significant P-gp inhibition was observed in vivo (section 4.5).
Croatian: Nije opažena značajna P-gp inhibicija in vivo (dio 4.5).
English: Rubraca blocks an enzyme that repairs damaged DNA in the cancer cells, resulting in their death.
Croatian: Rubraca blokira enzim koji popravlja oštećenu DNK u stanicama raka, što rezultira smrću tih stanica
English: Oxidation, N-demethylation, N-methylation, glucuronidation, and N-formylation were the major metabolic pathways for rucaparib.
Croatian: Oksidacija, Ndemetilacija, N-metilacija, glukuronidacija i N-formilacija bili su glavni metabolički putevi za rukaparib.
English: This is because Rubraca can affect the way some other medicines work.
Croatian: To je zbog toga jer Rubraca može utjecati na djelovanje nekih lijekova.
English: Blood tests
Croatian: Pretrage krvi
English: If the levels have not recovered to CTCAE Grade 1 or better after 4 weeks, the patient should be referred to a haematologist for further investigations.
Croatian: Ako se razine nakon 4 tjedna ne oporave na CTCAE 1. stupnja ili bolje od tog, bolesnicu treba uputiti hematologu radi daljnjih pretraga.
English: Patients who had been hospitalised for bowel obstruction in the last 3 months were excluded.
Croatian: Bolesnice koje su bile hospitalizirane zbog opstrukcije crijeva u posljednja 3 mjeseca su bile isključene.
English: The mean half-life (t1/2) of rucaparib was 25.9 hours.
Croatian: Srednja vrijednost poluvijeka (t1/2) rukapariba bila je 25,9 sati.
English: Rucaparib was not mutagenic in a bacterial reverse mutation (Ames) assay.
Croatian: Rukaparib nije bio mutagen u testu bakterijske reverzne mutacije (Ames).
English: Four (0.4%) patients reported a CTCAE Grade 3 reaction.
Croatian: Kod četiri bolesnice (0,4 %) zabilježena je reakcija CTCAE 3. stupnja.
English: PFS assessed by blinded independent radiology review (BIR) was a key secondary efficacy outcome.
Croatian: Blinded independent radiology review, BIR), bio je ključni sekundarni ishod učinkovitosti.
English: • changes in the way food tastes
Croatian: • promjena okusa hrane
English: The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Croatian: Irska Na tiskanoj uputi o lijeku mora se navesti naziv i adresa proizvođača odgovornog za puštanje navedene serije u promet.
English: Frequencies of occurrence of adverse reactions are defined as: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1000); very rare
Croatian: vrlo često (≥ 1/10); često (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i <
English: Patients should not start Rubraca treatment until they have recovered from haematological toxicities caused by previous chemotherapy (≤ CTCAE Grade 1).
Croatian: Bolesnice ne trebaju početi liječenje lijekom Rubraca sve dok se ne oporave od hematoloških toksičnosti uzrokovanih prethodnom kemoterapijom (≤ CTCAE 1. stupnja).
English: Check with your doctor, pharmacist, or nurse if you are not sure.
Croatian: Provjerite s liječnikom, ljekarnikom ili medicinskom sestrom ako niste sigurni.
English: Interactions between rucaparib and oral contraceptives have not been studied.
Croatian: Nisu proučavane interakcije između rukapariba i oralnih kontraceptiva.
English: What Rubraca is and what it is used for What Rubraca is and how it works
Croatian: Što je Rubraca i za što se koristi Što je Rubraca i kako djeluje
English: Rubraca should not be used during pregnancy unless the clinical condition of the woman requires treatment with rucaparib.
Croatian: Lijek Rubraca se ne smije primjenjivati u trudnoći osim ako kliničko stanje žene ne zahtijeva liječenje rukaparibom.
English: If MDS/AML is suspected, the patient should be referred to a haematologist for further investigations, including bone marrow analysis and blood sampling for cytogenetics.
Croatian: Ako postoji sumnja na MDS/AML, bolesnicu treba uputiti hematologu radi daljnjih pretraga, uključujući analizu koštane srži i uzorkovanje krvi za citogenetske pretrage.
English: Elevations in creatinine with rucaparib treatment may be due to inhibition of the renal transporters MATE1 and MATE2-K (see section 4.5).
Croatian: Povišene vrijednosti kreatinina u liječenju rukaparibom mogu nastati zbog inhibicije bubrežnih transportera MATE1 i MATE2-K (vidjeti dio 4.5).
English: There is no specific treatment in the event of Rubraca overdose, and symptoms of overdose are not established.
Croatian: Ne postoji specifično liječenje u slučaju predoziranja lijekom Rubraca i nisu utvrđeni simptomi predoziranja.
English: K67 P6K2, Ireland
Croatian: K67 P6K2, Irska
English: If you take Rubraca because your cancer has progressed you will need to have a clinical test to identify an abnormality in the BRCA gene.
Croatian: Ako uzimate lijek Rubraca jer je Vaš rak uznapredovao, morat ćete obaviti kliničku pretragu da bi se utvrdila abnormalnost gena BRCA.
English: Greater sensitivity of some elderly patients (≥ 65 years of age) to adverse events cannot be ruled out.
Croatian: Ne može se isključiti veća osjetljivosti na štetne događaje kod nekih starijih bolesnika (u dobi od ≥ 65 godina).
English: Central BRCA testing was performed retrospectively after patients were enrolled.
Croatian: BRCA testiranje provedeno je retrospektivno nakon uključivanja bolesnica.
English: What Rubraca is used for
Croatian: Za što se Rubraca koristi
English: There are no or limited data from the use of rucaparib in pregnant women.
Croatian: Ne postoje ili su ograničeni podaci o primjeni rukapariba u trudnica.
English: • Rubraca is available as either 200 mg, 250 mg or 300 mg tablets.
Croatian: • Rubraca je dostupna kao tableta od 200 mg, 250 mg ili 300 mg.
English: • The usual recommended dose is 600 mg twice a day.
Croatian: • Uobičajena preporučena doza je 600 mg dva puta dnevno.
English: In addition, rucaparib is an inhibitor of the BCRP with IC50 value suggesting potential BCRP inhibition and increased exposures of medicinal products that are BCRP substrates (e.g., rosuvastatin).
Croatian: Pored toga, rukaparib je inhibitor BCRP-a s vrijednošću IC50 koja ukazuje na potencijalnu inhibiciju BCRP-a i povećane izloženosti lijekovima koji su supstrati BCRP-a (npr. rosuvastatin).
English: As inhibition of these transporters could increase metformin renal elimination and decrease liver uptake of metformin, caution is advised when metformin is co-administered with rucaparib.
Croatian: Budući da inhibicija ovih transportera može povećati bubrežnu eliminaciju metformina i smanjiti unos metformina u jetru, savjetuje se oprez kad se metformin primjenjuje istodobno s rukaparibom.
English: AST/ALT elevations may need to be managed with treatment interruption and/or dose reduction as described in Table 2 (see section 4.2).
Croatian: Povišene vrijednosti ASTa/ALT-a možda će se trebati zbrinuti prekidom liječenja i/ili smanjenjem doze kako je opisano u Tablici 2 (vidjeti dio 4.2).
English: The median duration of response was 196 days (95% CI [113 - NA]).
Croatian: Medijan trajanja odgovora bio je 196 dana (95 % CI [113 - NA]).
English: Based on population PK analysis, no clinically significant relationships were identified between predicted steady-state exposure and patient's age, race, and body weight.
Croatian: Na temelju populacijske PK analize, nisu identificirani klinički značajni odnosi između predviđene izloženosti u stanju dinamičke ravnoteže i dobi, rase i tjelesne težine bolesnika.
English: All patients had potential contributing factors for the development of MDS/AML; in all cases, patients had received previous platinumcontaining chemotherapy regimens and/or other DNA damaging agents.
Croatian: Sve bolesnice imale su potencijalne faktore koji su doprinijeli razvoju MDS/AML-a; u svim slučajevima bolesnice su prethodno primile režim kemoterapije koji sadrži platinu i/ili druge lijekove koji oštećuju DNK.
English: No adjustment is recommended to the starting dose for elderly patients (≥ 65 years of age) (see sections 4.8 and 5.2).
Croatian: Ne preporučuje se prilagodba početne doze za starije bolesnice (u dobi od ≥ 65 godina) (vidjeti dijelove 4.8 i 5.2).
English: What Rubraca is and what it is used for What you need to know before you take Rubraca How to take Rubraca
Croatian: Što je Rubraca i za što se koristi Što morate znati prije nego počnete uzimati lijek Rubraca Kako uzimati lijek Rubraca
English: Kaplan-Meier Curves of Progression-Free Survival in ARIEL3 as Assessed by Investigator: ITT population
Croatian: Slika 1. Kaplan-Meierove krivulje preživljenja bez progresije bolesti u ispitivanju ARIEL 3 prema procjeni ispitivača: ITT populacija
English: Rubraca is for oral use and can be taken with or without food.
Croatian: Rubraca je namjenjena za peroralnu primjenu i može se uzeti sa ili bez hrane.
English: No effects on male and female fertility were observed in 3-month general toxicology studies in rats and dogs at exposures of 0.09 to 0.3 times the human AUC at the recommended dose.
Croatian: Nisu opaženi učinci na plodnost mužjaka i ženki u 3-mjesečnim ispitivanjima opće toksikologije na štakorima i psima pri izloženosti od 0,09 do 0,3 puta AUC-a u ljudi pri preporučenoj dozi.
English: The primary efficacy outcome measure of both studies was objective response rate (ORR) as assessed by the investigator according to RECIST version 1.1.
Croatian: Mjera primarnog ishoda djelotvornosti u oba ispitivanja bila je stopa objektivnog odgovora (objective response rate, ORR) prema procjeni ispitivača u skladu s verzijom 1.1. RECIST-a.
English: Interaction of rucaparib with other enzymes and transporter was evaluated in vitro.
Croatian: Interakcija rukapariba s drugim enzimima i transporterima procijenjena je in vitro.
English: Effect of other medicinal products on rucaparib
Croatian: Učinak drugih lijekova na rukaparib
English: In vitro studies have shown that rucaparibinduced cytotoxicity involves inhibition of PARP enzymatic activity and the trapping of PARP-DNA complexes resulting in increased DNA damage, apoptosis, and cell death.
Croatian: In vitro ispitivanja pokazala su da citotoksičnost izazvana rukaparibom uključuje inhibiciju enzimske aktivnosti PARP-a i hvatanje PARP-DNK kompleksa što dovodi do povećanog oštećenja DNK-a, apoptoze i smrti stanice.
English: Rucaparib is an inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, including PARP-1, PARP-2, and PARP-3, which play a role in DNA repair.
Croatian: Rukaparib je inhibitor enzima poli(ADP-riboza) polimeraze (PARP), uključujući PARP-1, PARP-2 i PARP-3, koji igra ulogu u popravku DNK-a.
English: Women of childbearing potential/contraception in females
Croatian: Žene u reproduktivnoj dobi/kontracepcija u žena
English: Rubraca can be used as maintenance therapy immediately after a course of chemotherapy that has caused the tumour to shrink.
Croatian: Rubraca se može primjenjivati kao terapija održavanja odmah nakon ciklusa kemoterapije kojom je postignuto smanjenje tumora.
English: In the pivotal Phase 3 study (ARIEL3), the incidence of MDS/AML during therapy in patients who received rucaparib was 0.8%.
Croatian: U pivotalnom ispitivanju faze 3 (ARIEL3) incidencija MDS/AML-a tijekom liječenja u bolesnica koje su primale rukaparib iznosila je 0,8 %.
English: The mean absolute oral bioavailability following a single oral dose of 12 to 120 mg rucaparib was 36%.
Croatian: Srednja vrijednost apsolutne peroralne bioraspoloživosti nakon jedne peroralne doze od 12 do 120 mg rukapariba bila je 36 %.
English: Rubraca is used to treat a type of cancer of the ovary.
Croatian: Rubraca se koristi za liječenje jedne vrste raka jajnika.
English: Tell your doctor, pharmacist or nurse if you are taking any of the following medicines:
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako uzimate neke od sljedećih lijekova:
English: Supportive care and institutional guidelines should be implemented for the management of low blood counts for the treatment of anaemia and neutropenia.
Croatian: Potrebno je primijeniti suportivnu njegu i smjernice ustanove za zbrinjavanje niskog broja krvnih stanica s ciljem liječenja anemije i neutropenije.
English: The clinical relevance of UGT1A1 inhibition by rucaparib is not clear.
Croatian: Klinička relevantnost inhibicije UGT1A1 rukaparibom nije jasna.
English: No interaction with MRP2 or MRP3 was observed in vitro at the clinical exposure of rucaparib, however, mild bi-phasic activation and inhibition of MRP2 and concentration dependent inhibition of MRP3 were observed at concentrations higher than the observed plasma Cmax of rucaparib.
Croatian: Nije opažena nikakva interakcija s MRP2 ili MRP3 in vitro pri kliničkoj izloženosti rukaparibu, međutim, blaga bi-fazna aktivacija i inhibicija MRP2 i inhibicija MRP3 ovisna o koncentraciji opažene su pri koncentracijama višim od uočenog Cmax rukapariba u plazmi.
English: The pharmacokinetic characteristics of rucaparib in patients with CLcr less than 30 mL/min or patients on dialysis are unknown (see section 4.2).
Croatian: Farmakokinetičke karakteristike rukapariba u bolesnica s CLcr manjim od 30 ml/min ili bolesnica na dijalizi nisu poznate (vidjeti dio 4.2).
English: The European Medicines Agency has waived the obligation to submit the results of studies with Rubraca in all subsets of the paediatric population in ovarian cancer (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obavezu podnošenja rezultata ispitivanja lijeka Rubraca u svim podskupinama pedijatrijske populacije za rak jajnika (vidjeti dio 4.2 za informacije o primjeni u pedijatriji).
English: Rubraca should be interrupted or dose reduced according to Table 1 (see section 4.2) and blood counts monitored weekly until recovery.
Croatian: Primjenu doza lijeka Rubraca treba prekinuti ili smanjiti dozu prema Tablici 1 (vidjeti dio 4.2) i svaki tjedan pratiti broj krvnih stanica sve do oporavka.
English: Rubraca can also be used if your cancer has progressed after chemotherapy has been used and you have an abnormality of the BRCA gene.
Croatian: Rubraca se također može primjenjivati ako je Vaš rak napredovao nakon primjene kemoterapije a imate abnormalnost gena BRCA.
English: Also some other medicines can affect the way Rubraca works.
Croatian: Također, neki drugi lijekovi mogu utjecati na djelovanje lijeka Rubraca.
English: Although no cases were reported during therapy in patients who received placebo, one case has been reported in a placebo - treated patient during the long term safety follow up.
Croatian: Iako u bolesnica koje su primale placebo nije prijavljen nijedan slučaj za samo vrijeme trajanja njegove primjene, jedan slučaj u bolesnice koja je primala placebo prijavljen je tijekom dugoročnog sigurnosnog praćenja.
English: All patients had achieved a response (complete or partial) to their most recent platinum-based chemotherapy and their cancer antigen 125 (CA-125) was below the upper limit of normal (ULN).
Croatian: Sve bolesnice postigle su odgovor (potpun ili djelomičan) na zadnju kemoterapiju na bazi platine a karcinomski antigen 125 (CA-125) bio im je ispod gornje granice normale (GGN).
English: The overall safety profile of rucaparib is based on data from 937 patients in clinical trials in ovarian cancer treated with rucaparib monotherapy.
Croatian: Cjelokupni sigurnosni profil rukapariba temelji se na podacima iz kliničkih ispitivanja raka jajnika u 937 bolesnica liječenih monoterapijom rukaparibom.
English: Other moderate to severe non-haematological adverse reactions such as nausea and vomiting, can be managed through dose interruption and/or reductions, if not adequately controlled by appropriate symptomatic management.
Croatian: Druge umjerene do teške nehematološke nuspojave poput mučnine i povraćanja mogu se zbrinjavati prekidima primjene doza i/ili smanjenjem doze ako se adekvatno ne kontroliraju odgovarajućim zbrinjavanjem simptoma.
English: Caution should be used when rucaparib is co-administered with UGT1A1 substrates (i.e. irinotecan) to patients with UGT1A1*28 (poor metabolizer) due to a possible increase in the exposure of SN-38 (the active metabolite of irinotecan) and associated toxicities.
Croatian: Potreban je oprez prilikom istodobne primjene rukapariba i supstrata UGT1A1 (tj. irinotekana) kod pacijenata s UGT1A1*28 (slab metabolizator) radi mogućeg povećanja izlaganju SN-38 (aktivnom metabolitu irinotekana) i povezanom toksičnošću.
English: Gastrointestinal toxicities (nausea and vomiting) are frequently reported with rucaparib, are generally low grade (CTCAE Grade 1 or 2), and may be managed with dose reduction (refer to Table 1) or interruption.
Croatian: Gastrointestinalne toksičnosti (mučnina i povraćanje) često prijavljene s rukaparibom, općenito su niskog stupnja (CTCAE 1. ili 2. stupnja) i mogu se zbrinjavati smanjenjem doze (vidjeti Tablicu 1) ili prekidom.
English: P-gp substrates
Croatian: Supstrati P-gp
English: Each bottle contains 60 film-coated tablets.
Croatian: Jedna boca sadrži 60 filmom obloženih tableta.
English: For risk mitigation and management, see section 4.4.
Croatian: Za ublažavanje rizika i zbrinjavanje, vidjeti dio 4.4.
English: Although no cardiac effects were observed following oral dosing, based on the findings in the intravenous studies and safety margins, cardiac effects in patients cannot be excluded when rucaparib is given orally.
Croatian: Iako nisu uočeni kardiološki učinci nakon peroralnog doziranja lijeka, na temelju rezultata ispitivanja s intravenskom primjenom i granica sigurnosti, kardiološki učinci u bolesnica ne mogu se isključiti pri peroralnom davanju rukapariba.
English: Clovis Oncology Ireland Ltd. Regus Dublin Airport Skybridge House - Dublin Airport Swords
Croatian: Regus Dublin Airport Skybridge House - Dublin Airport Swords
English: Tumour tissue samples for all of the patients (N=564) were tested centrally to determine HRD positive status (as defined by the presence of a deleterious tumour BRCA [tBRCA] mutation or high genomic loss of heterozygosity).
Croatian: Uzorci tumorskog tkiva za sve bolesnice (N = 564) centralno su testirani kako bi se utvrdio pozitivan HRD status (kako se definira prisutnošću štetne mutacije gena BRCA [tBRCA] u tumorskom tkivu ili visokim genomskim gubitkom heterozigotnosti).
English: Talk to your doctor if you feel sick (nauseous), have been sick (vomiting) or you have had diarrhoea.
Croatian: Razgovarajte sa svojim liječnikom ako imate mučninu, povraćanje ili ste imali proljev.
English: The most abundant metabolite was M324, an oxidative deamination product of rucaparib, accounting for 18.6% of the radioactivity in plasma.
Croatian: Najobilniji metabolit bio je M324, produkt rukapariba koji nastaje oksidativnom deaminacijom i odgovoran je za 18,6 % radioaktivnosti u plazmi.
English: Ninety percent of the observed faecal recovery was achieved within 168 hours postdose.
Croatian: Devedest posto zabilježenog fekalnog oporavka postignuto je unutar 168 sati nakon doze.
English: The duration of therapy with rucaparib in patients who developed MDS/AML varied from less than 1 month to approximately 28 months.
Croatian: Trajanje terapije rukaparibom u bolesnica koje su razvile MDS/AML variralo je u rasponu od manje od 1 mjeseca do približno 28
English: The time of onset for adverse reactions of myelosuppression Grade 3 or higher was generally later in treatment (after 2 or more months).
Croatian: Vrijeme do početka nuspojava mijelosupresije stupnja 3. ili više bilo je uglavnom kasnije u liječenju (nakon 2 ili više mjeseci).