FrancophonIA/ELRC3.0 huggingface dataset:
English: Docetaxel belongs to the group of anti-cancer medicines called taxoids.
Slovenian: Docetaksel spada v skupino zdravil za zdravljenje raka, imenovanih taksoidi.
English: If you had an allergic reaction to paclitaxel, you may also experience an allergic reaction to docetaxel, which may be more severe.
Slovenian: Če ste imeli alergijsko reakcijo na paklitaksel, se vam lahko pojavi tudi alergijska reakcija na docetaksel, ki pa je lahko hujša.
English: Stratified log rank test *Threshold for statistical significance = 0.0175 **PSA: Prostate-Specific Antigen
Slovenian: Stratificiran log-rang test *Prag statistične značilnosti = 0,0175 **PSA: prostatični specifični antigen
English: • redness and swelling of the palms of your hands or soles of your feet which may cause your skin to peel (this may also occur on the arms, face, or body)
Slovenian: • pordelost in otekanje dlani ali podplatov, ki lahko povzroči olupljenje kože (to se lahko pojavi tudi na rokah, obrazu ali telesu)
English: Taxespira contains ethanol (alcohol)
Slovenian: Zdravilo Taxespira vsebuje etanol (alkohol)
English: This leaflet was last revised in {month YYYY}.
Slovenian: Navodilo je bilo nazadnje revidirano dne mesec LLLL
English: Pharmacotherapeutic group: antineoplastic agents, taxanes, ATC Code: L01CD02
Slovenian: Farmakoterapevtska skupina: Zdravila z delovanjem na novotvorbe, taksani, oznaka ATC: L01CD02
English: • infections, decrease in the number of red blood cells (anaemia), or white blood cells (which are important in fighting infection) and platelets (important in blood clotting)
Slovenian: • okužbe, zmanjšanještevila rdečih krvnih celic (anemija), belih krvnih celic (ki so pomembne za premagovanje okužbe) in trombocitov (pomembni za strjevanje krvi)
English: In about 20% of these cases there were no risk factors for acute renal failure such as concomitant nephrotoxic medicinal products and gastro-intestinal disorders.
Slovenian: V približno 20 % teh primerov ni bilo nobenih dejavnikov tveganja za akutno ledvično odpoved, sočasnih nefrotoksičnih zdravil in bolezni prebavil.
English: Use the vial immediately after its opening.
Slovenian: Vialo je treba uporabiti takoj po odprtju.
English: See also section “Taxespira contains ethanol (alcohol)” below.
Slovenian: Glejte tudi poglavje "Zdravilo Taxespira vsebuje etanol (alkohol)" spodaj.
English: 3) was 7 days), anaemia, alopecia, nausea, vomiting, stomatitis, diarrhoea and asthenia.
Slovenian: 3) pa 7 dni), anemija, alopecija, navzea, bruhanje, stomatitis, driska in astenija.
English: What you need to know before you use Taxespira
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Taxespira
English: Inflammation of the lungs can also develop when docetaxel therapy is used with radiotherapy)
Slovenian: Vnetje pljuč se lahko razvije tudi, če se zdravljenje z docetakselom uporablja sočasno z radioterapijo)
English: You must not become pregnant during treatment with this medicine and must use an effective method of contraception during therapy, because Taxespira may be harmful for the unborn baby.
Slovenian: Med zdravljenjem z zdravilom Taxespira ne smete zanositi in morate uporabljati učinkovito kontracepcijsko zaščito, ker zdravilo Taxespira lahko škoduje vašemu nerojenemu otroku.
English: What Taxespira is and what it is used for
Slovenian: Kaj je zdravilo Taxespira in za kaj ga uporabljamo
English: Hazard ratio (TAC/FAC)
Slovenian: Razmerje ogroženosti (TAC/FAC)
English: Docetaxel is metabolised by CYP3A4 and prednisone is known to induce CYP3A4.
Slovenian: Docetaksel se metabolizira s CYP3A4, za prednizon pa je znano, da inducira CYP3A4.
English: Taxespira will be administered to you by a healthcare professional.
Slovenian: Zdravilo Taxespira vam bo dal pristojni zdravstveni delavec.
English: The name of this medicine is Taxespira.
Slovenian: To zdravilo se imenuje Taxespira.
English: The amount of alcohol in this medicinal product and the side effects of the product may impair the ability to drive or use machines (see sections 4.4 and 4.8).
Slovenian: Količina alkohola v tem zdravilu in neželeni učinki zdravila lahko poslabšajo sposobnost vožnje in upravljanja s stroji (glejte poglavji 4.4 in 4.8).
English: Symptoms such as early abdominal pain and tenderness, fever, diarrhoea, with or without neutropenia, may be early manifestations of serious gastrointestinal toxicity and should be evaluated and treated promptly.
Slovenian: Simptomi kot so: abdominalne bolečine in občutljivost, pireksija, driska z ali brez nevtropenije, so lahko zgodnja manifestacija resne gastrointestinalne toksičnosti ter jih je potrebno nemudoma ovrednotiti in zdraviti.
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE
Slovenian: B. POGOJI ALI OMEJITVEGLEDE OSKRBE IN UPORABE
English: • decrease in blood pressure; irregular or rapid heart beat
Slovenian: • znižanje krvnega tlaka, nereden ali hiter srčni utrip
English: • Mitoxantrone 12 mg/m
Slovenian: • Mitoksantron12 mg/m
English: In case of white blood cells disturbances, you may experience associated fever or infections.
Slovenian: Če imate spremenjeno število belih krvnih celic, se lahko pojavijo zvišana telesna temperatura ali okužbe.
English: Taxespira was administered as a 1-hour infusion, all other medicinal products were given intravenously on day 1 every three weeks.
Slovenian: Zdravilo Taxespira je bilo uporabljeno v 1-urni infuziji, vsa druga zdravila pa intravensko 1. dan na tri tedne.
English: Neutropenia (Grade 4) Febrile neutropenia Neutropenic infection Neutropenic infection (Grade 3-4)
Slovenian: Nevtropenija (4. stopnje) Febrilna nevtropenija Nevtropenična okužba Nevtropenična okužba (3.-4. stopnja)
English: Blood and lymphatic system disorders Rare: bleeding episodes associated with grade 3/4 thrombocytopenia.
Slovenian: Bolezni krvi in limfatičnega sistema Redki: krvavitve povezane s trombocitopenijo stopnje 3/4.
English: Discuss with your doctor if you suffer from alcohol dependency, epilepsy, or liver impairment.
Slovenian: Posvetujte se z zdravnikom, če ste odvisni od alkohola, imate epilepsijo ali okvaro jeter.
English: Exploratory subgroup analyses for disease-free survival for patients who meet the 2009 St. Gallen chemotherapy criteria - (ITT population) were performed and presented here below:
Slovenian: Opravljene so bile eksplorativne analize podskupin glede preživetja brez bolezni pri bolnicah, ki izpolnjujejo St.-Gallenska merila 2009 za kemoterapijo (populacija ZNZ); predstavljene so spodaj
English: It is important that you read the entire contents of this guide prior to the preparation of the Taxespira infusion solution.
Slovenian: Pomembno je, da pred pripravo zdravila Taxespira v celoti preberete ta navodila.
English: It should be used within 6 hours (including the one hour
Slovenian: Porabiti jo je treba v 6 urah (ena ura infundiranja všteta).
English: The final analysis was performed when all patients had reached their 10-year follow-up visit (unless they had a DFS event or were lost to follow-up before).
Slovenian: Končna analiza je bila opravljena, ko so vse bolnice prišle na pregled po 10letnem spremljanju (razen če se jim je prej pojavil dogodek DFS ali so se prej izgubile spremljanju).
English: The most commonly reported adverse reactions of docetaxel alone are: neutropenia (which was reversible and not cumulative; the median day to nadir was 7 days and the median duration of severe neutropenia (<500 cells/mm
Slovenian: Najpogosteje opisani neželeni učinki na sam docetaksel so: nevtropenija (ki je bila reverzibilna in ni bila kumulativna; srednji čas do najmanjšega števila je bil 7 dni, srednje trajanje hude nevtropenije (< 500 celic/mm
English: Rare occurrences of dehydration have been reported as a consequence of gastrointestinal events including enterocolitis and gastrointestinal perforation.
Slovenian: Opisani so redki primeri dehidracije zaradi dogodkov, povezanih s prebavili vključno z enterokolitisom in gastrointestinalno perforacijo.
English: Disseminated intravascular coagulation (DIC), often in association with sepsis or multiorgan failure, has been reported.
Slovenian: Poročali so o diseminirani intravaskularni koagulaciji (DIK), pogosto v povezavi s sepso ali multiorgansko odpovedjo.
English: 1,000 mg/m2 per day for 5 days.
Slovenian: (1000 mg/m2 na dan, 5 dni).
English: Each vial is for single use and should be used immediately after opening.
Slovenian: Vsaka viala je namenjena za enkratno uporabo in jo je treba uporabiti takoj po odprtju.
English: Patients who received docetaxel every three weeks demonstrated significantly longer OS compared to those treated with mitoxantrone.
Slovenian: Pri bolnikih, ki so prejemali docetaksel vsake tri tedne so prikazali značilno daljše skupno preživetje v primerjavi s tistimi, ki so bili zdravljeni z mitoksantronom.
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the label of the vial after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in na nalepki na viali poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: • fever: if this happens you must tell your doctor immediately
Slovenian: • zvišana telesna temperatura: če se vam to zgodi, morate nemudoma povedati zdravniku
English: • Periodic safety update reports
Slovenian: • Redno posodobljenaporočila o varnosti zdravila (PSUR)
English: Patients in both treatment arms were to receive 7 weeks of CRT following induction chemotherapy with a minimum interval of 3 weeks and no later than 8 weeks after start of the last cycle (day 22 to day 56 of last cycle).
Slovenian: Bolniki v obeh terapevtskih krakih so po indukcijski kemoterapiji dobili 7 tednov kemoradioterapije; najkrajši presledek je bil 3 tedne in ne več kot 8 tednov po začetku zadnjega ciklusa (22. do 56. dan zadnjega ciklusa).
English: Patients who experience febrile neutropenia and/or neutropenic infection should have their docetaxel dose reduced to 60 mg/m2 in all subsequent cycles (see sections 4.4 and 4.8).
Slovenian: Bolnicam, ki se jim pojavi febrilna nevtropenija in/ali nevtropenična okužba, je treba odmerek docetaksela v vseh nadaljnjih ciklusih zmanjšati na 60 mg/m2 (glejte poglavji 4.4 in 4.8).
English: • pneumonia (infection of the lungs)
Slovenian: • pljučnica (okužba pljuč)
English: 95% CI p =
Slovenian: 95 % IZ p =
English: • haemorrhage (bleeding)
Slovenian: • hemoragija (krvavitev)
English: • For any subsequent appearances of toxicities, or any Grade 4 toxicities, discontinue the docetaxel dose.
Slovenian: • V primeru vsakega ponovnega pojava toksičnih učinkov ali pojava toksičnih učinkov 4. stopnje, odmerek docetaksela prekinite.
English: If you develop acute or worsening problems with your lungs (fever, shortness of breath or cough), please tell your doctor, hospital pharmacist or nurse immediately.
Slovenian: Če se pojavijo akutne težave s pljuči ali pride do poslabšanja simptomov (povišana telesna temperatura, težko dihanje/kratka sapa ali kašelj), takoj obvestite svojega zdravnika, medicinsko sestro ali bolnišničnega farmacevta.
English: Acute leukaemia /Myelodysplastic syndrome
Slovenian: Akutna levkemija / mielodisplastični sindrom
English: Hormonal receptor status
Slovenian: Stanje hormonskih receptorjev Negativno
English: If a dose greater than 190 mg of docetaxel is required, use a larger volume of the infusion vehicle so that a concentration of 0.74 mg/ml docetaxel is not exceeded.
Slovenian: Če je potrebni odmerek večji od 190 mg docetaksela, uporabite več infuzijskega vehikla, tako da končna koncentracija v raztopini za infundiranje ne preseže koncetracije docetaksela 0,74 mg/ml.
English: In addition, docetaxel was found to be active on some but not all cell lines over expressing the p-glycoprotein which is encoded by the multidrug resistance gene.
Slovenian: Poleg tega je ugotovljeno, da je docetaksel aktiven na nekaterih, ne pa na vseh celičnih linijah s hipereksprimiranim pglikoproteinom, ki ga kodira gen za rezistenco proti več zdravilom.
English: Meeting relative indication for chemotherapy No
Slovenian: Izpolnjena relativna indikacija za kemoterapijo
English: If you are a man being treated with Taxespira you are advised not to father a child during and up to 6 months after treatment and to seek advice on conservation of sperm prior to treatment because Docetaxel may alter male fertility.
Slovenian: Če ste moški, ki se zdravi z zdravilom Taxespira je priporočljivo, da ne zaplodite otroka med zdravljenjem in v obdobju 6 mesecev po koncu zdravljenja ter da pred začetkom zdravljenja poiščete nasvet glede ohranitve sperme, ker docetaksel lahko prizadene moško plodnost.
English: Taxespira must NOT be administered if you are pregnant unless clearly indicated by your doctor.
Slovenian: Zdravila Taxespira NE smete dobiti, če ste noseči, razen če vam vaš zdravnik ne odredi drugače.
English: One hundred eighty six patients were randomized to receive docetaxel (100 mg/m2) with or without trastuzumab; 60% of patients received prior anthracycline-based adjuvant chemotherapy.
Slovenian: Stošestinosemdeset (186) bolnic je bilo randomiziranih na prejemanje docetaksela (100 mg/m2) s trastuzumabom ali brez njega; 60 % bolnic je prej dobilo adjuvantno kemoterapijo na osnovi antraciklinov.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION
Slovenian: IME ZDRAVILA IN POT(I) UPORABE ZDRAVILA
English: Each vial is of single use and should be used immediately.
Slovenian: Vsaka viala je za enkratno uporabo in jo je treba uporabiti takoj.
English: If the vials are stored under refrigeration, allow the required number of boxes of Taxespira concentrate for solution for infusion to stand below 25°C for 5 minutes before use.
Slovenian: Če so viale shranjene v hladilniku, pred uporabo pustite potrebno število škatel zdravila Taxespira koncentrat za raztopino za infundiranje 5 minut stati na sobni temperaturi (do 25°C).
English: 3, or in patients who experience febrile neutropenia, or in patients with serious non-haematologic toxicities, the docetaxel dose in subsequent cycles should be reduced to 65 mg/m2.
Slovenian: 3, bolnikom, ki doživijo febrilno nevtropenijo, in bolnikom z resnimi nehematološkimi toksičnimi učinki je treba odmerek docetaksela v naslednjih ciklusih zmanjšati na 65 mg/m2.
English: In vivo, docetaxel is schedule independent and has a broad spectrum of experimental antitumour activity against advanced murine and human grafted tumours.
Slovenian: In vivo docetaksel ni odvisen od sheme in ima širok spekter eksperimentalnega protitumorskega delovanja proti napredovalim mišjim in humanim transplantiranim tumorjem.
English: Taxespira concentrate for solution for infusion requires NO prior dilution with a solvent and is ready to add to the infusion solution.
Slovenian: Zdravila Taxespira koncentrat za raztopino za infundiranje predhodno NI potrebno redčiti z vehiklom in je pripravljeno za dodajanje v infuzijsko raztopino.
English: This regimen was administered every three weeks for 4 cycles in case at least a minor response (≥25% reduction in bidimensionally measured tumour size) was observed after 2 cycles.
Slovenian: To shemo so uporabljali 4 cikluse vsake 3 tedne, če so po 2 ciklusih opazili vsaj majhen odziv (≥ 25 % zmanjšanje dvodimenzionalno merjene velikosti tumorja).
English: In non-clinical studies, docetaxel has genotoxic effects and may alter male fertility (see section 5.3).
Slovenian: V predkliničnih študijah so opazili genotoksične učinke docetaksela in lahko prizadene moško plodnost (glejte poglavje 5.3).
English: 3 for seven days or more) during a course of docetaxel therapy, a reduction in dose for subsequent courses of therapy or the use of appropriate symptomatic measures are recommended (see section 4.2).
Slovenian: 3 sedem dni ali več), je med naslednjimi ciklusi priporočljivo zmanjšati odmerek ali uporabiti ustrezne simptomatske ukrepe (glejte poglavje 4.2).
English: The European Medicines Agency has waived the obligation to submit the results of studies with Taxespira in all subsets of the paediatric population in breast cancer, non-small cell lung cancer, prostate cancer, gastric carcinoma and head and neck cancer, not including type II and III less differentiated nasopharyngeal carcinoma (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila (EMA) je odstopila od obveze za predložitev rezultatov študij z zdravilom Taxespira za vse skupine pediatrične populacije za raka dojke, nedrobnoceličnega pljučnega raka, raka prostate, karcinom želodca in raka glave in vratu, ne vključujoč manj diferenciiran nazofaringealni karcinom tipa II oz. III (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: TAC = docetaxel, doxorubicin and cyclophosphamide FAC = 5-fluorouracil, doxorubicin and cyclophosphamide CI = confidence interval; ER = estrogen receptor PR = progesterone receptor
Slovenian: TAC = docetaksel, doksorubicin in ciklofosfamid FAC = 5-fluorouracil, doksorubicin in ciklofosfamid IZ = interval zaupanja, ER = estrogenski receptor PR = progesteronski receptor a negativno ER/PR ali 3. stopnja ali velikost tumorja > 5 cm
English: The incidence of the following adverse events (all grades): lethargy, stomatitis, neutropenic infection occurred at rates ≥ 10% higher in patients who were 65 years of age or older compared to younger patients.
Slovenian: Incidenca naslednjih neželenih učinkov (vse stopnje) - letargije, stomatitisa in nevtropenične okužbe - je bila pri bolnikih, starih 65 let ali več, ≥ 10 % večja kot pri mlajših bolnikih.
English: The pharmacokinetics of docetaxel have been evaluated in cancer patients after administration of 20-115 mg/m2 in phase I studies.
Slovenian: Absorpcija Farmakokinetiko docetaksela so ocenili pri onkoloških bolnikih po uporabi 20-115 mg/m2 v študijah I. faze.
English: Median duration of response to chemotherapy ± radiotherapy (months) (95% CI)
Slovenian: Mediano trajanje odziva na kemoterapijo radioterapijo(meseci) (95 % IZ)
English: From a microbiological point of view, reconstitution/dilution must take place in controlled and aseptic conditions.
Slovenian: Z mikrobiološkega vidika morata rekonstitucija/redčenje potekati v nadzorovanih in aseptičnih pogojih.
English: • at the injection site, skin reactions, phlebitis (inflammation of the vein) or swelling
Slovenian: • na mestu injiciranja, kožne reakcije, flebitis (vnetje vene) ali otekanje
English: If not used immediately, in-use storage times and conditions are the responsibility of the user and would normally not be longer than 6 hours below 25°C including the one hour infusion.
Slovenian: Če zdravilo ni uporabljeno takoj, je za čas in pogoje hranjenja med uporabo odgovoren uporabnik in ne sme biti daljši kot 6 ur pri temperaturi do 25°C, pri čemer je ena ura infundiranja všteta v ta čas.
English: • blurred vision due to swelling of the retina within the eye (cystoid macular oedema)
Slovenian: • zamegljen vid zaradi oteklosti očesne mrežnice (cistoidni makularni edem)
English: 2-year estimate (%)
Slovenian: 2-letno preživetje (%)
English: • swelling caused by faulty lymphatic drainage
Slovenian: • otekanje zaradi nepravilnelimfatične drenaže
English: In combination with trastuzumab the recommended dose of docetaxel is 100 mg/m2 every three weeks, with trastuzumab administered weekly.
Slovenian: Za kombinacijo s trastuzumabom je priporočeni odmerek docetaksela 100 mg/m2 vsake tri tedne, s tedensko aplikacijo trastuzumaba.
English: A population pharmacokinetic analysis has been performed with docetaxel in 577 patients.
Slovenian: Starost in spol Farmakokinetične analize docetaksela na populaciji so opravili pri 577 bolnikih.
English: Cases of permanent alopecia (frequency not known) have been reported.
Slovenian: Opisani so bili primeri trajne plešavosti (pogostnost neznana).
English: • tiredness or flu-like symptoms
Slovenian: • utrujenost ali gripi podobni simptomi
English: These reactions were described using the NCI Common Toxicity Criteria (grade 3 = G3; grade 3-4 = G3/4; grade 4 = G4), the COSTART and the MedDRA terms.
Slovenian: Neželeni učinki so bili opisani po merilih NCI Common Toxicity Criteria (3. stopnja = S3, 3.-4. stopnja = S3/4, 4. stopnja = S4) in z izrazi COSTART in MedDRA.
English: For combination with capecitabine, the most frequent treatment-related undesirable effects (≥5%) reported in a phase III study in breast cancer patients failing anthracycline treatment are presented (see capecitabine summary of product characteristics).
Slovenian: Pri kombinaciji s kapecitabinom so predstavljeni najpogostejši z zdravljenjem povezani neželeni učinki (≥ 5 %), o katerih so poročali v fazi III klinične študije pri bolnicah z rakom dojke z neuspelim zdravljenjem z antraciklini (prosimo, glejte povzetek glavnih značilnosti kapecitabina).
English: The most commonly reported adverse reactions of Taxespira alone are: decrease in the number of red blood cells or white blood cells, alopecia (hair loss), nausea, vomiting, sores in the mouth, diarrhoea and tiredness.
Slovenian: Najpogosteje poročani neželeni učinki zdravila Taxespira samega so: zmanjšanje števila rdečih ali belih krvnih celic, alopecija (izguba las), siljenje na bruhanje, bruhanje, razjede v ustih, driska in utrujenost.
English: • difficulty or painful swallowing
Slovenian: • težave ali bolečine pri požiranju
English: PREPARATION GUIDE FOR USE WITH TAXESPIRA CONCENTRATE FOR SOLUTION FOR INFUSION
Slovenian: NAVODILA ZA UPORABO ZDRAVILA TAXESPIRA KONCENTRAT ZA RAZTOPINO ZA INFUNDIRANJE
English: The kinetic profile of docetaxel is dose independent and consistent with a three-compartment pharmacokinetic model with half lives for the α, β and γ phases of 4 min, 36 min and 11.1 h, respectively.
Slovenian: Kinetični profil docetaksela ni odvisen od odmerka in se sklada s trirazdelčnim farmakokinetičnim modelom, pri čemer je razpolovni čas faze α 4 minute, β 36 minut in γ 11,1 ure.
English: Subset analyses-adjuvant therapy in patients with node-negative breast cancer study (intent-to-treat analysis)
Slovenian: Analize podskupine - adjuvantno zdravljenje bolnic v študiji raka dojke z negativnimi bezgavkami (analiza z-namenom-zdravljenja)
English: 5-fluorouracil (F) 750 mg/m2 per day as a continuous infusion for 5 days.
Slovenian: fluorouracil (F) 750 mg/m2 na dan v obliki neprekinjene infuzije 5 dni.
English: Post-Menopausal *a hazard ratio (TAC/FAC) of less than 1 indicates that TAC is associated with a longer disease free survival compared to FAC.
Slovenian: Po menopavzi *a razmerje ogroženosti Vrednost (TAC/FAC) manj kot 1 pomeni, da je kombinacija TAC povezana z daljšim preživetjem brez bolezni kot kombinacija FAC.
English: The safety and efficacy of docetaxel in combination with prednisone or prednisolone in patients with hormone refractory metastatic prostate cancer were evaluated in a randomized multicenter phase III study.
Slovenian: Varnost in učinkovitost docetaksela v kombinaciji s prednizonom ali prednizolonom pri bolnikih z metastatskim hormonsko neodzivnim rakom prostate je bila ocenjena v randominizirani multicentrični študiji faze III.
English: In the pivotal SCCHN studies patients who experienced complicated neutropenia (including prolonged neutropenia, febrile neutropenia, or infection), it was recommended to use G-CSF to provide prophylactic coverage (e.g., day 6-15) in all subsequent cycles.
Slovenian: V ključnih SCCHN študijah pri bolnikih, pri katerih se je pojavila komplicirana nevtropenija (ki vključuje dolgotrajno nevtropenijo, fibrilno nevtropenijo ali okužbo), je bilo priporočeno, naj se v vseh naslednjih ciklih za profilaktično kritje (na primer med 6. in 15. dnem) uporablja G-CSF.
English: How to use Taxespira
Slovenian: Kako uporabljati zdravilo Taxespira
English: Therefore, men being treated with docetaxel are advised not to father a child during and up to 6 months after treatment and to seek advice on conservation of sperm prior to treatment
Slovenian: Zato je priporočljivo, da moški, ki se zdravijo z docetakselom, ne zaplodijo otroka med zdravljenjem in v obdobju šestih mesecev po koncu zdravljenja ter da pred začetkom zdravljenja poiščejo nasvet glede ohranitve sperme.
English: Overall
Slovenian: Celotno