FrancophonIA/ELRC3.0 huggingface dataset:
English: Treatment of essential hypertension.
Slovak: Zdravljenje esencialne hipertenzije.
English: It is important that you take Kinzalkomb every day until your doctor tells you otherwise.
Slovak: Zdravilo Kinzalkomb morate jemati vsak dan, dokler vam ga bo zdravnik predpisoval.
English: Thiazides have an effect on the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts.
Slovak: Tiazidi vplivajo na mehanizme ponovne absorpcije elektrolitov v ledvičnih tubulih in tako neposredno in v približno enakih količinah povečujejo izločanje natrija in klorida.
English: Telmisartan In patients taking telmisartan alone the following additional side effects have been reported:
Slovak: Pri bolnikih, ki so jemali samo telmisartan, so poročali še o naslednjih neželenih učinkih:
English: In case of surgery or anaesthetics, you should tell your doctor that you are taking Kinzalkomb.
Slovak: Če boste operirani ali boste dobili anestetike, morate zdravniku povedati, da jemljete zdravilo Kinzalkomb.
English: Other conditions with stimulation of the renin-angiotensin-aldosterone system
Slovak: Druga stanja, pri katerih prihaja do spodbujanja renin-angiotenzin-aldosteronskega sistema
English: Total plasma clearance of telmisartan after oral administration is >1500 ml/min.
Slovak: Skupni očistek telmisartana iz plazme je po peroralnem dajanju > 1500 ml/min.
English: Kinzalkomb is a combination of two active substances, telmisartan and hydrochlorothiazide in one tablet.
Slovak: Zdravilo Kinzalkomb je kombinacija dveh zdravilnih učinkovin, telmisartana in hidroklorotiazida v eni tableti.
English: • if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Slovak: • če imate sladkorno bolezen ali okvarjeno delovanje ledvic in se zdravite z zdravilom za znižanje krvnega tlaka, ki vsebuje aliskiren.
English: Pharmacokinetic studies in patients with hepatic impairment showed an increase in absolute bioavailability up to nearly 100 %.
Slovak: Farmakokinetične raziskave so pri bolnikih z jetrno okvaro odkrile skoraj 100-odstotno povečanje absolutne biološke uporabnosti.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 19 April 2002
Slovak: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve:
English: Kinzalkomb is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Slovak: Uporaba zdravila Kinzalkomb ni priporočljiva v zgodnjem obdobju nosečnosti in ga ne smete jemati, če ste noseči več kot 3 mesece, ker lahko v tem obdobju resno škoduje vašemu otroku (glejte poglavje o nosečnosti).
English: The glucuronide of the parent compound is the only metabolite that has been identified in humans.
Slovak: Glukuronid matične spojine je edini znani presnovek pri človeku.
English: Patients taking HCTZ should be informed of the risk of NMSC and advised to regularly check their skin for any new lesions and promptly report any suspicious skin lesions.
Slovak: Bolniki, ki se zdravijo s hidroklorotiazidom, morajo biti obveščeni o tveganju za razvoj nemelanomskega kožnega raka, in treba jim je svetovati, naj si redno pregledujejo kožo in naj takoj obvestijo zdravnika, če najdejo kakršne koli na novo nastale sumljive kožne spremembe.
English: Telmisartan is metabolised by conjugation to form a pharmacologically inactive acylglucuronide.
Slovak: Telmisartan se presnavlja s konjugacijo v farmakološko neaktivni acilglukuronid.
English: Hydrochlorothiazide should not be used for gestational oedema, gestational hypertension or preeclampsia due to the risk of decreased plasma volume and placental hypoperfusion, without a beneficial effect on the course of the disease.
Slovak: Hidroklorotiazida ne smemo uporabljati za zdravljenje gestacijskega edema, gestacijske hipertenzije ali preeklampsije zaradi možnosti zmanjšanja plazemskega volumna in pojava placentne hipoperfuzije, če ni ugodnega vpliva na potek bolezni.
English: pentamidine, sparfloxacine, terfenadine, vincamine IV.)
Slovak: sparfloksacin, terfenadin, vinkamin iv.).
English: In a follow-up trial with the 80 mg/25 mg combination, blood pressure was further decreased (resulting in an overall reduction of 11.5/9.9 mm Hg (SBP/DBP).
Slovak: V nadaljnji raziskavi s kombinacijo 80 mg/25 mg se je krvni tlak nadalje znižal (skupno za 11,5/9,9 mm Hg) (AKT/DKT).
English: NAME OF THE MARKETING AUTHORISATION HOLDER Bayer (Logo)
Slovak: IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM Bayer (Logo)
English: The toxicological findings observed appear to have no relevance to human therapeutic use.
Slovak: Kaže, da toksikološki izvidi v raziskavah na živalih za terapevtsko uporabo pri človeku niso pomembni.
English: Kinzalkomb with food and alcohol
Slovak: Zdravilo Kinzalkomb skupaj s hrano in alkoholom
English: Medicinal products affected by serum potassium disturbances
Slovak: Zdravila, na delovanje katerih vplivajo motnje serumskega kalija
English: Telmisartan does not show affinity for other receptors, including AT2 and other less characterised AT receptors.
Slovak: Telmisartan nima afinitete za druge receptorje, niti za AT2 niti za druge manj raziskane receptorje AT.
English: ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
Slovak: PRILOGA I POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA
English: No additional preclinical studies have been performed with the Fixed Dose Combination product 80 mg/25 mg.
Slovak: Dodatnih predkliničnih raziskav s fiksno kombinacijo zdravila 80 mg/25 mg niso izvedli.
English: These studies have shown no significant beneficial effect on renal and/or cardiovascular outcomes and mortality, while an increased risk of hyperkalaemia, acute kidney injury and/or hypotension as compared to monotherapy was observed.
Slovak: Ti študiji nista pokazali pomembne koristi glede ledvičnih in/ali kardiovaskularnih izidov ali umrljivosti, v primerjavi z monoterapijo pa so opažali večje tveganje za hiperkaliemijo, akutno odpoved ledvic in/ali hipotenzijo.
English: Adverse reactions of unknown frequency reported with the use of hydrochlorothiazide alone include: Infections and infestations
Slovak: Neželeni učinki neznane pogostnosti, o katerih so poročali med samostojno uporabo hidroklorotiazida: Infekcijske in parazitske bolezni
English: Occasionally, the outer layer of the blister pack separates from the inner layer between the blister pockets.
Slovak: Občasno se lahko zunanji sloj pretisnega omota loči od notranjega sloja med pretisnimi žepki.
English: Periodic monitoring of renal function is advised (see section 4.4).
Slovak: Priporočamo periodične kontrolne preglede delovanja ledvic (glejte poglavje 4.4).
English: If hypotension occurs, the patient should be placed in a supine position, with salt and volume replacements given quickly.
Slovak: Če se pojavi hipotenzija, bolnika namestimo v ležeč položaj in mu takoj začnemo nadomeščati sol in volumen.
English: The maximum reduction in blood pressure is generally attained 4-8 weeks after the start of treatment and is sustained during long-term therapy.
Slovak: Največje znižanje krvnega tlaka, ki ga telmisartan običajno doseže 4 do 8 tednov po začetku zdravljenja, se med dolgotrajnim zdravljenjem ne spreminja.
English: Tablets should be taken out of the blister shortly before administration.
Slovak: Tablete je treba vzeti iz pretisnega omota tik pred uporabo.
English: An increase in cholesterol and triglyceride levels has been associated with thiazide diuretic therapy; however, at the 12.5 mg dose contained in Kinzalkomb, minimal or no effects were reported.
Slovak: Z zdravljenjem s tiazidnimi diuretiki povezujejo povečanje ravni holesterola in trigliceridov, vendar za odmerek po 12,5 mg, ki ga vsebuje zdravilo Kinzalkomb, poročajo le o minimalnih ali nikakršnih tovrstnih učinkih.
English: These medicinal products may potentiate the effect of hydrochlorothiazide on serum potassium (see section 4.4).
Slovak: Ta zdravila lahko povečajo učinek hidroklorotiazida na serumski kalij (glejte poglavje 4.4).
English: Infants whose mothers have taken angiotensin II receptor antagonists should be closely observed for hypotension (see sections 4.3 and 4.4).
Slovak: Otroke, katerih matere so prejemale antagoniste angiotenzina II, je treba pozorno spremljati zaradi možnosti hipotenzije (glejte poglavji 4.3 in 4.4).
English: 4.1 Therapeutic indications
Slovak: Terapevtske indikacije
English: Kinzalkomb is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Slovak: Zdravila Kinzalkomb med nosečnostjo ne priporočajo; ne smete pa ga jemati, ko boste noseči več kot 3 mesece, ker lahko po tretjem mesecu nosečnosti resno škoduje vašemu otroku.
English: Hydrochlorothiazide is excreted almost entirely as unchanged substance in urine.
Slovak: Hidroklorotiazid se skoraj v celoti izloči v obliki nespremenjene učinkovine s sečem.
English: If calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) must be prescribed, serum calcium levels should be monitored and calcium dosage adjusted accordingly.
Slovak: Če so kalcijevi nadomestki ali zdravila, ki varčujejo s kalcijem, (npr. zdravljenje z vitaminom D) nujno potrebni, je treba spremljati serumsko raven kalcija in njegov odmerek ustrezno prilagoditi.
English: Cardiovascular prevention
Slovak: Preprečevanje srčnožilnih bolezni
English: Dual blockade of RAAS through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is therefore not recommended (see sections 4.5 and 5.1).
Slovak: Dvojna blokada sistema RAAS s hkratno uporabo zaviralcev ACE, blokatorjev receptorjev angiotenzina II ali aliskirena zato ni priporočljiva (glejte poglavji 4.5 in 5.1).
English: If you forget to take Kinzalkomb
Slovak: Če ste pozabili vzeti zdravilo Kinzalkomb
English: Occasionally, the outer layer of the blister pack has been observed to separate from the inner layer between the blister pockets.
Slovak: Občasno so zasledili, da se zunanji sloj pretisnega omota loči od notranjega sloja med pretisnimi žepki.
English: The antihypertensive efficacy of telmisartan is comparable to that of agents representative of other classes of antihypertensive medicinal products (demonstrated in clinical trials comparing telmisartan to amlodipine, atenolol, enalapril, hydrochlorothiazide, and lisinopril).
Slovak: Antihipertenzivna učinkovitost telmisartana je primerljiva z učinkovitostjo zdravil iz drugih skupin antihipertenzivnih zdravil (primerljivost dokazujejo klinična preskušanja, v katerih so telmisartan primerjali z amlodipinom, atenololom, enalaprilom, hidroklorotiazidom in lizinoprilom).
English: The use of Kinzalkomb during breast feeding is not recommended.
Slovak: Uporabe zdravila Kinzalkomb med dojenjem ne priporočajo.
English: The concomitant use of Kinzalkomb with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1).
Slovak: Sočasna uporaba zdravila Kinzalkomb in zdravil, ki vsebujejo aliskiren je kontraindicirana pri bolnikih s sladkorno boleznijo ali z okvaro ledvic (hitrost glomerularne filtracije < 60 ml/min/1,73 m2) (glejte poglavji 4.5 in 5.1).
English: The use of Kinzalkomb in children and adolescents up to the age of 18 years is not recommended.
Slovak: Uporabe zdravila Kinzalkomb pri otrocih in mladostnikih do 18. leta ne priporočamo.
English: C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORIZATION
Slovak: DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: Increase in dosage of probenecid or sulfinpyrazone may be necessary.
Slovak: Včasih je treba povečati odmerek probenecida ali sulfinpirazona.
English: Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma.
Slovak: Sulfonamid hidroklorotiazid lahko povzroči idiosinkratično reakcijo, ki ima za posledico akutno prehodno miopijo in akutni glavkom zaprtega zakotja.
English: Hydrochlorothiazide is not metabolised in man.
Slovak: Hidroklorotiazid se pri človeku ne presnavlja.
English: When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started.
Slovak: Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti in, če je primerno, začeti alternativno zdravljenje.
English: Investigations Rare:
Slovak: Preiskave Redki:
English: If any of the above applies to you, tell your doctor or pharmacist before taking Kinzalkomb.
Slovak: Če imate katero od naštetih stanj, povejte zdravniku ali farmacevtu preden boste vzeli zdravilo Kinzalkomb.
English: Bronchitis, pharyngitis, sinusitis
Slovak: bronhitis, faringitis, sinuzitis
English: Telmisartan blocks the effect of angiotensin II so that the blood vessels relax, and your blood pressure is lowered.
Slovak: Telmisartan prepreči učinek angiotenzina II, žile se sprostijo in krvni tlak se zniža.
English: If you have further questions on the use of this medicine, ask your doctor or pharmacist.
Slovak: Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom ali farmacevtom.
English: In addition, Kinzalkomb should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Slovak: Zdravilo Kinzalkomb moramo previdno dajati tudi bolnikom z motnjami delovanja jeter ali napredujočo jetrno boleznijo, ker lahko že manjše spremembe ravnovesja tekočin in elektrolitov povzročijo jetrno komo.
English: Rare cases have also been reported with angiotensin II receptor antagonists (including Kinzalkomb).
Slovak: O redkih tovrstnih primerih poročajo tudi za antagoniste angiotenzina II (vključno z zdravilom Kinzalkomb).
English: The inhibitory effect is maintained over 24 hours and still measurable up to 48 hours.
Slovak: Zaviralni učinek traja 24 ur, izmerimo pa ga lahko še do 48 ur po vnosu zdravila.
English: 14 tablets 28 tablets 56 tablets 98 tablets 28 x 1 tablets
Slovak: 14 tablet 28 tablet 56 tablet 98 tablet 28
English: You should consult with your doctor if you need to adjust the dose of your other medicine while taking Kinzalkomb.
Slovak: Z zdravnikom se morate posvetovati z zdravnikom, ali je treba med jemanjem zdravila Kinzalkomb prilagoditi odmerek vašega drugega zdravila.
English: Based on cumulative renal excretion of hydrochlorothiazide the absolute bioavailability was about 60 %.
Slovak: Glede na skupno količino hidroklorotiazida, ki se izloči skozi ledvice, je njegova absolutna biološka uporabnost približno 60-odstotna.
English: ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage.
Slovak: Študijo ONTARGET so izvedli pri bolnikih, ki so imeli anamnezo kardiovaskularne ali cerebrovaskularne bolezni ali sladkorno bolezen tipa 2 z znaki okvare končnih organov.
English: Experience with Kinzalkomb is modest in the patients with mild to moderate renal impairment, therefore periodic monitoring of potassium, creatinine and uric acid serum levels is recommended.
Slovak: Z zdravilom Kinzalkomb je malo izkušenj pri bolnikih z blago do zmerno zmanjšanim delovanjem ledvic, zato so priporočljivi periodični kontrolni pregledi serumskih ravni kalija, kreatinina in sečne kisline.
English: Description of selected adverse reactions
Slovak: Opis izbranih neželenih učinkov
English: Very rare side effects (may affect up to 1 in 10,000 people): Increased pH (disturbed acid-base balance) due to low blood chloride level.
Slovak: Zelo redki neželeni učinki (lahko se pojavijo pri največ 1 od 10.000 bolnikov): povišan pH (porušeno ravnovesje med kislino in bazo) zaradi nizke ravni klorida v krvi.
English: Very rare:
Slovak: Zelo redki:
English: Untreated acute angle-closure glaucoma can lead to permanent vision loss.
Slovak: Nezdravljeni akutni glavkom zaprtega zakotja lahko povzroči trajno izgubo vida.
English: Combining telmisartan with ramipril did not add further benefit over ramipril or telmisartan alone.
Slovak: Kombiniranje telmisartana in ramiprila ni pokazalo dodatne prednosti v primerjavi z jemanjem samo ramiprila ali samo telmisartana.
English: Telmisartan is an orally effective and specific angiotensin II receptor subtype 1 (AT1) antagonist.
Slovak: Telmisartan je peroralno učinkovit antagonist receptorjev angiotenzina II, podtipa 1 (AT1), s specifičnim delovanjem.
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children.
Slovak: POSEBNO OPOZORILO O SHRANJEVANJU ZDRAVILA ZUNAJ DOSEGA IN POGLEDA OTROK
English: VA NEPHRON-D was a study in patients with type 2 diabetes mellitus and diabetic nephropathy.
Slovak: Študija VA NEPHRON-D je zajela bolnike s sladkorno boleznijo tipa 2 in diabetično nefropatijo.
English: Excipients with known effect
Slovak: Pomožne snovi z znanim učinkom:
English: The use of angiotensin II receptor antagonists is contraindicated during the second and third trimesters of pregnancy (see sections 4.3 and 4.4).
Slovak: Uporaba antagonistov angiotenzina II je kontraindicirana v drugem in tretjem trimesečju nosečnosti (glejte poglavji 4.3. in 4.4).
English: ** Cases of progressive scarring of lung tissue have been reported during intake of telmisartan.
Slovak: ** Poročali so o primerih progresivnega brazgotinjenja pljučnega tkiva med jemanjem telmisartana, vendar ni znano ali je vzrok telmisartan.
English: Kinzalkomb contains milk sugar (lactose) and sorbitol.
Slovak: Zdravilo Kinzalkomb vsebuje mlečni sladkor (laktozo) in sorbitol.
English: Possible side effects
Slovak: Možni neželeni učinki
English: An 80 mg dose of telmisartan administered to healthy volunteers almost completely inhibits the angiotensin II evoked blood pressure increase.
Slovak: Pri zdravih prostovoljcih odmerek telmisartana po 80 mg skoraj povsem zavre zvišanje krvnega tlaka, ki ga povzroča angiotenzin II.
English: Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system.
Slovak: Na splošno se bolniki s primarnim aldosteronizmom ne odzivajo na antihipertenzive, ki delujejo z zaviranjem renin-angiotenzinskega sistema, zato zanje zdravljenja z zdravilom Kinzalkomb ne priporočamo.
English: Not all pack sizes may be marketed.
Slovak: Na trgu morda ni vseh navedenih pakiranj.
English: Not known:
Slovak: Neznana:
English: The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium.
Slovak: Diuretični učinek hidroklorotiazida zmanjša volumen plazme, poveča aktivnost renina v plazmi in izločanje aldosterona, zaradi česar se poveča izguba kalija s sečem in bikarbonata ter zmanjša količina kalija v serumu.
English: Reporting of suspected adverse reactions
Slovak: Poročanje o domnevnih neželenih učinkih
English: As with all other angiotensin II receptor antagonists, telmisartan is apparently less effective in lowering blood pressure in black patients than in non blacks, possibly because of higher prevalence of low renin states in the black hypertensive population.
Slovak: Kaže, da telmisartan, tako kot drugi antagonisti receptorjev angiotenzina II, manj učinkovito znižuje krvni tlak pri črni kot pri drugih rasah, kar je verjetno posledica večje razširjenosti stanj z manjšo količino renina pri osebah črne rase, ki imajo hipertenzijo.
English: Based on available data from epidemiological studies, cumulative dose-dependent association between HCTZ and NMSC has been observed (see also sections 4.4 and 5.1).
Slovak: Na podlagi obstoječih podatkov epidemioloških študij so ugotovili, da obstaja razmerje med kumulativnim odmerkom hidroklorotiazida in nemelanomskim kožnim rakom (glejte tudi poglavji 4.4 in 5.1).
English: Gastric lesions could be prevented/ameliorated by oral saline supplementation and group housing of animals.
Slovak: Poškodbe v želodcu so lahko preprečili ali ublažili s peroralnim dajanjem solne raztopine in s skupinsko nastanitvijo živali.
English: ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both.
Slovak: Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) je preučevala koristi dodatka aliskirena standardnemu zdravljenju z zaviralcem ACE ali blokatorjem receptorjev angiotenzina II pri bolnikih s sladkorno boleznijo tipa 2 in kronično boleznijo ledvic, kardiovaskularno boleznijo ali obojim.
English: The effects of fixed dose combination of telmisartan/HCTZ on mortality and cardiovascular morbidity are currently unknown.
Slovak: Učinki fiksne kombinacije telmisartana in hidroklorotiazida na umrljivost in obolevnost zaradi srčnožilnih bolezni še niso raziskani.
English: The incidence of dry cough was significantly lower in patients treated with telmisartan than in those given angiotensin converting enzyme inhibitors in clinical trials directly comparing the two antihypertensive treatments.
Slovak: Pogostnost suhega kašlja je bila med bolniki, ki so se zdravili s telmisartanom, pomembno manjša kot pri tistih, ki so jemali zaviralce angiotenzinske konvertaze, kar dokazujejo rezultati kliničnih preskušanj, v katerih so neposredno primerjali obe vrsti antihipertenzivov.
English: Digitalis glycosides
Slovak: Glikozidi digitalisa
English: This includes any possible side effects not listed in this leaflet.
Slovak: Posvetujte se tudi, če opazite katere koli neželene učinke, ki niso navedeni v tem navodilu.
English: In one study the co-administration of telmisartan and ramipril led to an increase of up to 2.5 fold in the AUC0-24 and Cmax of ramipril and ramiprilat.
Slovak: V eni študiji sta se med sočasnim dajanjem telmisartana in ramiprila do 2,5-krat povečala AUC0-24 in Cmax ramiprila in ramiprilata.
English: Calcium salts
Slovak: Kalcijeve soli
English: Non-steroidal anti-inflammatory medicinal products NSAIDs (i.e. acetylsalicylic acid at anti-inflammatory dosage regimens, COX-2 inhibitors and nonselective NSAIDs) may reduce the diuretic, natriuretic and antihypertensive effects of thiazide diuretics and the antihypertensive effects of angiotensin II receptor antagonists.
Slovak: Nesteroidna protivnetna zdravila (acetilsalicilna kislina v odmerkih, ki učinkujejo protivnetno, zaviralci ciklooksigenaze 2 in neselektivna nesteroidna protivnetna zdravila) lahko zmanjšajo diuretičnidiuretične, natriuretični natriuretične in antihipertenzivne učinke tiazidnih diuretikov ter antihipertenzivne učinke antagonistov receptorjev angiotenzina II.
English: What Kinzalkomb is and what it is used for
Slovak: Kaj je zdravilo Kinzalkomb in za kaj ga uporabljamo