FrancophonIA/ELRC3.0 huggingface dataset:
English: CYP2C9 is likely also induced.
Croatian: Vjerojatno dolazi i do indukcije CYP2C9.
English: - Examples of medicinal products that are metabolised by CYP2B6 include bupropion.
Croatian: - Primjeri lijekova koji se metaboliziraju putem CYP2B6 uključuju bupropion.
English: Anti-arrhythmic medicinal products amiodarone
Croatian: Antiaritmici amiodaron
English: -Examples of such medicinal products include HMG Co-A reductase inhibitors, fexofenadine, repaglinide and glyburide (see Table 1).
Croatian: - Primjeri takvih lijekova uključuju inhibitore HMG Co-A reduktaze, feksofenadin, repaglinid i gliburid (vidjeti Tablicu 1).
English: - Examples of P-gp/BCRP inhibitors include clarithromycin,erythromycin, azitromycin, itraconazole, ketoconazole, verapamil, quinidine, fluvoxamine, ranolazine, and some of the HIV protease inhibitors.
Croatian: - Primjeri inhibitora P-gp-a/BCRP-a uključuju klaritromicin, eritromicin, azitromicin, itrakonazol, ketokonazol, verapamil, kinidin, fluvoksamin, ranolazin i neke inhibitore HIV proteaze.
English: Expected; ↔ fluconazole ↔ letermovir
Croatian: Očekivano: ↔ flukonazol ↔ letermovir
English: In the pre- and post-natal developmental study, letermovir was administered orally to pregnant rats.
Croatian: U ispitivanju razvoja prije i nakon okota letermovir se primjenjivao peroralno skotnim ženkama štakora.
English: If you are on a low sodium diet, talk to your doctor before you are given this medicine.
Croatian: Ako ste na dijeti s niskim unosom natrija, obratite se svom liječniku prije nego što primite ovaj lijek.
English: (CYP2C8 induction, CYP2C8 and OATP1B inhibition)
Croatian: (indukcija CYP2C8, inhibicija CYP2C8 i OATP1B)
English: PREVYMIS 240 mg concentrate for solution for infusion contains 23 mg (or 1.0 mmol) sodium per dose.
Croatian: 240 mg koncentrat za otopinu za infuziju sadrži 23 mg (ili 1,0 mmol) natrija po dozi.
English: If they do not remember until it is time for the next dose, they should skip the missed dose and go back to the regular schedule.
Croatian: Ako se sjeti tek kad je već vrijeme za sljedeću dozu, treba preskočiti propuštenu dozu i nastaviti uzimati lijek prema uobičajenom rasporedu.
English: If PREVYMIS is coadministered with cyclosporine (a potent OATP1B1/3 inhibitor), the recommended dose of PREVYMIS is 240 mg once daily (see Table 1 and sections 4.2 and 5.2).
Croatian: Ako se PREVYMIS primjenjuje istodobno s ciklosporinom (snažnim inhibitorom OATP1B1/3), preporučena doza lijeka PREVYMIS je 240 mg jedanput na dan (vidjeti Tablicu 1 i dijelove 4.2 i 5.2).
English: This medicinal product contains 46 mg (2.0 mmol) sodium per 480 mg vial, equivalent to 2.30% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Croatian: Ovaj lijek sadrži 46 mg (2,0 mmol) natrija po bočici od 480 mg, što odgovara 2,30% maksimalnog dnevnog unosa od 2 g natrija prema preporukama SZO za odraslu osobu.
English: • feeling like you are spinning (vertigo)
Croatian: • osjećaj da se sve oko Vas okreće (vrtoglavica)
English: Risk of ↓ contraceptive steroids Letermovir may reduce plasma concentrations of other oral contraceptive steroids thereby affecting their efficacy.
Croatian: Letermovir može sniziti koncentracije drugih oralnih steroidnih kontraceptiva u plazmi i tako utjecati na njihovu djelotvornost.
English: Posology PREVYMIS is also available as concentrate for solution for infusion (240 mg and 480 mg).
Croatian: PREVYMIS je dostupan i u obliku koncentrata za otopinu za infuziju (240 mg i 480 mg).
English: The medicine helps stop you from getting ill from CMV (‘cytomegalovirus').
Croatian: On pomaže spriječiti razvoj bolesti koju uzrokuje citomegalovirus (CMV).
English: Medicinal products metabolised by CYP3A
Croatian: Lijekovi koji se metaboliziraju putem CYP3A
English: No dose recommendation can be made for patients with end stage renal disease (ESRD) with or without dialysis.
Croatian: Ne može se dati preporuka o doziranju za bolesnike u terminalnoj fazi bubrežne bolesti, bez obzira na to jesu li na dijalizi ili ne.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke vrste šećera, posavjetujte se sa svojim liječnikom prije uzimanja ovog lijeka.
English: See the package leaflet for your other medicine for further information.
Croatian: Za dodatne informacije pogledajte uputu o lijeku za drugi lijek koji uzimate.
English: PREVYMIS concentrate for solution for infusion is physically incompatible with amiodarone hydrochloride, amphotericin B (liposomal), aztreonam, cefepime hydrochloride, ciprofloxacin, cyclosporine, diltiazem hydrochloride, filgrastim, gentamicin sulfate, levofloxacin, linezolid, lorazepam, midazolam HCl, mycophenolate mofetil hydrochloride, ondansetron, palonosetron.
Croatian: PREVYMIS koncentrat za otopinu za infuziju fizički je inkompatibilan s amiodaronkloridom, amfotericinom B (liposomskim), aztreonamom, cefepimkloridom, ciprofloksacinom, ciklosporinom, diltiazemkloridom, filgrastimom, gentamicinsulfatom, levofloksacinom, linezolidom, lorazepamom, midazolamkloridom, mofetilmikofenolatkloridom, ondanzetronom i palonozetronomo.
English: If letermovir is co-administered with cyclosporine, the recommended dose of letermovir is 240 mg once daily (see section 4.2).
Croatian: Ako se letermovir primjenjuje istodobno s ciklosporinom, preporučena doza letermovira je 240 mg jedanput na dan (vidjeti dio 4.2).
English: Letermovir may increase or decrease the plasma concentrations of repaglinide.
Croatian: Letermovir može povisiti ili sniziti koncentracije repaglinida u plazmi.
English: If you also take cyclosporine, your doctor will decrease the dose of PREVYMIS to one 240 mg tablet once a day.
Croatian: Ako uz to uzimate i ciklosporin, liječnik će Vam smanjiti dozu lijeka PREVYMIS na jednu tabletu od 240 mg jedanput na dan.
English: The elimination pathways of letermovir in vivo are biliary excretion and glucuronidation.
Croatian: Putovi eliminacije letermovira in vivo su izlučivanje putem žuči i glukuronidacija.
English: Letermovir may decrease the plasma concentrations of CYP2C19 substrates.
Croatian: Letermovir može sniziti koncentracije supstrata CYP2C19 u plazmi.
English: Concomitant use is not recommended glyburide
Croatian: Ne preporučuje se istodobna primjena gliburid
English: List of compatible medicinal products when PREVYMIS and medicinal products* are prepared in 0.9% sodium chloride
Croatian: Popis kompatibilnih lijekova* koji se mogu koristiti kada se PREVYMIS i drugi lijekovi pripremaju s 0,9%-tnom otopinom natrijeva klorida
English: PREVYMIS contains cyclodextrin
Croatian: PREVYMIS sadrži ciklodekstrin
English: (OATP1B1/3 inhibition CYP3A inhibition, CYP2C9 induction)
Croatian: (inhibicija OATP1B1/3, inhibicija CYP3A, indukcija CYP2C9)
English: When PREVYMIS is co-administered with cyclosporine, also refer to the sirolimus prescribing information for specific dosing recommendations for use of sirolimus with cyclosporine.
Croatian: Kada se PREVYMIS primjenjuje istodobno s ciklosporinom, vidjeti i informacije o lijeku za sirolimus za specifične preporuke za doziranje kod primjene sirolimusa u kombinaciji s ciklosporinom.
English: The major elimination pathways of letermovir is biliary excretion as well as direct glucuronidation.
Croatian: Glavni putovi eliminacije letermovira su izlučivanje putem žuči i izravna glukuronidacija.
English: When PREVYMIS is co-administered with cyclosporine, refer also to the glyburide prescribing information for specific dosing recommendations.
Croatian: Kada se PREVYMIS primjenjuje istodobno s ciklosporinom, vidjeti i informacije o lijeku za gliburid za specifične preporuke za doziranje.
English: The primary efficacy endpoint of clinically significant CMV infection in P001 was defined by the incidence of CMV DNAemia warranting anti-CMV pre-emptive therapy (PET) or the occurrence of CMV end-organ disease.
Croatian: Primarna mjera ishoda za djelotvornost u ispitivanju P001 - klinički značajna CMV infekcijadefinirala se kao razina CMV DNK u krvi koja je zahtijevala primjenu preemptivne terapije (PET) protiv CMV-a ili razvoj bolesti ciljnog organa uzrokovane CMV-om.
English: What PREVYMIS contains
Croatian: Što PREVYMIS sadrži
English: Each carton contains four (4) cardboard, each containing a 7-count blister card for a total of 28 tablets.
Croatian: Jedna kutija sadrži četiri (4) kartonske kartice, od kojih svaka sadrži blister karticu sa 7 tableta, ukupno 28 tableta.
English: Do not use this medicine after the expiry date which is stated on the carton and vial after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i bočici iza oznake "EXP".
English: • If you have any further questions, ask your doctor, pharmacist, or nurse.
Croatian: • Ako imate dodatnih pitanja, obratite se liječniku, ljekarniku ili medicinskoj sestri.
English: Therapeutic drug monitoring (TDM) is therefore recommended for voriconazole.
Croatian: Stoga se preporučuje terapijsko praćenje koncentracija vorikonazola.
English: PREVYMIS is an antiviral prescription medicine that contains the active substance letermovir.
Croatian: PREVYMIS je antivirusni lijek koji se izdaje na recept i sadrži djelatnu tvar letermovir.
English: With NC=F approach, subjects who discontinued from the study prior to Week 24 post-transplant or had a missing outcome at Week 24 post-transplant were counted as failures.
Croatian: Prema NC=F pristupu, ispitanike koji su prekinuli ispitivanja prije 24. tjedna nakon transplantacije ili za koje su nedostajali podaci o ishodu u 24. tjednu nakon transplantacije smatralo se neuspješno liječenima.
English: The diluted solution should be inspected visually for particulate matter and discolouration prior to administration, whenever solution and container permit.
Croatian: Prije primjene razrijeđenu otopinu treba pregledati vizualno zbog moguće prisutnosti čestica i promjene boje, kad god to otopina i spremnik dopuštaju.
English: Each mL contains 20 mg of letermovir.
Croatian: Jedan ml sadrži 20 mg letermovira.
English: The changes in letermovir exposure in subjects with moderate hepatic impairment are not clinically relevant.
Croatian: Promjene u izloženosti letermoviru u ispitanika s umjerenim oštećenjem funkcije jetre nisu klinički značajne.
English: • Norepinephrine bitartrate
Croatian: • cefazolinnatrij norepinefrin bitartarat
English: Viral resistance
Croatian: Virusna rezistencija
English: Gastrointestinal disorders Common nausea, diarrhoea, vomiting
Croatian: Poremećaji probavnog sustava Često mučnina, proljev, povraćanje
English: There is no experience with human overdose with PREVYMIS.
Croatian: Nema iskustva s predoziranjem lijekom PREVYMIS u ljudi.
English: Mismatched unrelated (n=43, 24)
Croatian: Darivatelj s nepodudarnošću koji nije krvni srodnik (n=43, 24)
English: This medicinal product contains 23 mg (1.0 mmol) sodium per 240 mg vial, equivalent to 1.15% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Croatian: Ovaj lijek sadrži 23 mg (1,0 mmol) natrija po bočici od 240 mg, što odgovara 1,15% maksimalnog dnevnog unosa od 2 g natrija prema preporukama SZO za odraslu osobu.
English: No maternal or developmental effects were noted at the dose of 50 mg/kg/day (approximately 2.5-fold the AUC at the RHD).
Croatian: Pri dozi od 50 mg/kg na dan nisu opaženi nikakvi učinci na majku ni razvoj ploda (izloženost približno 2,5 puta veća od AUC-a nakon primjene preporučene doze za ljude).
English: This should be taken into consideration by patients on a controlled sodium diet.
Croatian: O tome treba voditi računa u bolesnika na dijeti s ograničenim unosom natrija.
English: Patients should be instructed that if they miss a dose of PREVYMIS, they should take it as soon as they remember.
Croatian: Ako bolesnik propusti uzeti dozu lijeka PREVYMIS, treba ga uputiti da je uzme čim se sjeti.
English: Primary efficacy endpoint
Croatian: Primarna mjera ishoda za djelotvornost
English: Peripheral blood (n=241, 117)
Croatian: Periferna krv (n=241, 117) Koštana srž (n=72, 43)
English: HIV medicinal products efavirenz
Croatian: Lijekovi protiv HIV-a efavirenz
English: -Examples of strong inducers include rifampicin, phenytoin, carbamazepine, St. John's wort (Hypericum perforatum), rifabutin and phenobarbital.
Croatian: - Primjeri snažnih induktora uključuju rifampicin, fenitoin, karbamazepin, gospinu travu (Hypericum perforatum), rifabutin i fenobarbital.
English: Yellow oval tablet of dimensions 16.5 mm x 8.5 mm, debossed with “591” on one side and MSD logo on the other side.
Croatian: Žuta ovalna tableta dimenzija 16,5 mm x 8,5 mm, s utisnutom oznakom '591' na jednoj strani i logotipom MSD na drugoj strani.
English: After uptake, glucuronidation of letermovir is mediated by UGT1A1 and 3.
Croatian: Nakon unosa u jetru slijedi glukuronidacija letermovira u kojoj posreduju UGT1A1 i 3.
English: Lactose monohydrate, hypromellose (E464), titanium dioxide (E171), triacetin (E1518), iron oxide yellow (E172), iron oxide red (only for 480 mg tablets) (E172), carnauba wax (E903).
Croatian: Laktoza hidrat, hipromeloza (E464), titanijev dioksid (E171), triacetin (E1518), žuti željezov oksid (E172), crveni željezov oksid (samo za tablete od 480 mg) (E172), karnauba vosak (E903).
English: If you also take cyclosporine, your doctor will decrease the dose of PREVYMIS to 240 mg once a day.
Croatian: Ako uz to uzimate i ciklosporin, liječnik će Vam smanjiti dozu lijeka PREVYMIS na 240 mg jedanput na dan.
English: Although not studied, when PREVYMIS is co-administered with cyclosporine, the magnitude of the increase in atorvastatin plasma concentrations is expected to be greater than with PREVYMIS alone.
Croatian: Iako se to nije ispitivalo, očekuje se da će koncentracije atorvastatina u plazmi porasti više kada se PREVYMIS primjenjuje istodobno s ciklosporinom nego kada se primjenjuje sam.
English: List of compatible medicinal products when PREVYMIS and medicinal products* are prepared in 5% dextrose
Croatian: Popis kompatibilnih lijekova* koji se mogu koristiti kada se PREVYMIS i drugi lijekovi pripremaju s 5%-tnom otopinom glukoze
English: Dose adjustment of CYP3A metabolised opioids may be needed
Croatian: Možda će biti potrebno prilagoditi dozu opioida koji se metaboliziraju putem CYP3A
English: (likely due to induction of CYP2C19)
Croatian: (vjerojatno zbog indukcije CYP2C19)
English: Figure 2: P001: Forest plot of the proportion of subjects initiating anti-CMV PET or with CMV end-organ disease through Week 24 post-transplant by selected subgroups (NC=F approach, FAS population)
Croatian: Slika 2: P001: Grafikon raspona pouzdanosti (engl. forest plot) za udio ispitanika kojima je uveden PET protiv CMV-a ili u kojih se razvila bolest ciljnog organa uzrokovana CMV-om do 24. tjedna nakon transplantacije prema odabranim podskupinama (NC=F pristup, FAS populacija)
English: • voriconazole - for fungal infections
Croatian: • vorikonazol - koristi se za liječenje gljivičnih infekcija
English: • If cyclosporine is initiated after starting PREVYMIS, the next dose of PREVYMIS should be decreased to 240 mg once daily.
Croatian: • Ako se ciklosporin uvede nakon početka liječenja lijekom PREVYMIS, sljedeću dozu lijeka PREVYMIS treba smanjiti na 240 mg jedanput na dan.
English: Frequent monitoring of glucose concentrations is recommended the first 2 weeks after initiating or ending letermovir, as well as after changing route of administration of letermovir.
Croatian: Preporučuje se često kontrolirati koncentracije glukoze tijekom prva 2 tjedna nakon uvođenja ili nakon prekida primjene letermovira, kao i nakon promjene puta primjene letermovira.
English: Each 480 mg film-coated tablet contains less than 1 mmol sodium (23 mg).
Croatian: Jedna filmom obložena tableta od 480 mg sadrži manje od 1 mmol natrija (23 mg).
English: Each 480 mg film-coated tablet contains 6.4 mg of lactose (as monohydrate).
Croatian: Jedna filmom obložena tableta od 480 mg sadrži 6,4 mg laktoze (u obliku hidrata).
English: Carbamazepine or phenobarbital may decrease plasma concentrations of letermovir.
Croatian: Karbamazepin ili fenobarbital mogu sniziti koncentracije letermovira u plazmi.
English: Any unused portion of the infusion solution should be discarded.
Croatian: Preostala neupotrijebljena otopina za infuziju mora se baciti.
English: Renal and urinary disorders Uncommon blood creatinine increased
Croatian: Poremećaji bubrega i mokraćnog sustava Manje često povišene vrijednosti kreatinina u krvi
English: • modafinil - for wakefulness
Croatian: • modafinil - koristi se za budnost
English: Expected: ↓ dabigatran
Croatian: Očekivano: ↓ dabigatran
English: Medicinal products transported by OATP1B1/3
Croatian: Lijekovi koje prenosi OATP1B1/3
English: Interaction at steady state not studied.
Croatian: Interakcija u stanju dinamičke ravnoteže se nije ispitivala.
English: PREVYMIS contains lactose monohydrate.
Croatian: PREVYMIS sadrži laktozu hidrat.
English: Pink oval, bi-convex tablet of dimensions 21.2 mm x 10.3 mm, debossed with “595” on one side and MSD logo on the other side.
Croatian: Ružičasta, ovalna, bikonveksna tableta dimenzija 21,2 mm x 10,3 mm, s utisnutom oznakom '595' na jednoj strani i logotipom MSD na drugoj strani.
English: The 480 mg tablets are packaged into a carton containing four (4) cardboard cards, each containing a 7-count Polyamide/Aluminium/PVC - Aluminium blister card for a total of 28 tablets.
Croatian: Tablete od 480 mg pakirane su u kutiju koja sadrži četiri (4) kartonske kartice, od kojih svaka sadrži poliamidnu/aluminijsku/PVC - aluminijsku blister karticu sa 7 tableta, ukupno 28 tableta.
English: Frequent monitoring of cyclosporine whole blood concentrations should be performed during treatment, when changing PREVYMIS administration route, and at discontinuation of PREVYMIS and the dose of cyclosporine adjusted accordingly cyclosporine (200 mg single dose)/ letermovir (240 mg daily)
Croatian: Potrebno je često kontrolirati koncentracije ciklosporina u punoj krvi tijekom liječenja, kada se mijenja put primjene lijeka PREVYMIS i po prestanku liječenja lijekom PREVYMIS te sukladno njima prilagoditi dozu ciklosporina ciklosporin (jedna doza od 200 mg)/letermovir (240 mg na dan)
English: Expected: ↑ quinidine
Croatian: Očekivano: ↑ kinidin
English: (600 mg once daily PO (24 hours after rifampicin)) letermovir (480 mg once daily PO)
Croatian: (600 mg jedanput na dan peroralno (24 sata nakon rifampicina)) letermovir (480 mg jedanput na dan peroralno)
English: • Magnesium sulfate
Croatian: • antitimocitni globulin magnezijev sulfat
English: There was no testicular toxicity in rats at exposures (AUC) similar to the exposures in humans at the RHD.
Croatian: Nije bilo toksičnih učinaka na testise štakora pri razinama izloženosti (AUC) sličnima onima koje se postižu u ljudi nakon primjene preporučene doze za ljude.
English: In healthy subjects, the geometric mean steady-state AUC and Cmax values were 71,500 ng•hr/mL and 13,000 ng/mL, respectively, with 480 mg once daily oral letermovir.
Croatian: U zdravih je ispitanika geometrijska srednja vrijednost AUC-a i Cmax u stanju dinamičke ravnoteže nakon peroralne primjene letermovira u dozi od 480 mg jedanput na dan iznosila 71 500 ng•h/ml odnosno 13 000 ng/ml.
English: Administration of PREVYMIS may result in a clinically relevant increase in plasma concentrations of co-administered medicinal products that are OATP1B1/3 substrates.
Croatian: Primjena lijeka PREVYMIS može dovesti do klinički važnih porasta koncentracija istodobno primijenjenih supstrata prijenosnika OATP1B1/3 u plazmi.
English: In HSCT recipients, bioavailability of letermovir was estimated to be approximately 35% with 480 mg once daily oral letermovir administered without cyclosporine.
Croatian: Procijenjena bioraspoloživost letermovira u primatelja HSCT-a iznosila je približno 35% kada se letermovir primjenjivao peroralno u dozi od 480 mg jedanput na dan bez ciklosporina.
English: Based on population pharmacokinetic analyses, letermovir steady-state apparent CL is estimated to be 4.84 L/hr following intravenous administration of 480 mg in HSCT recipients.
Croatian: Prema populacijskim farmakokinetičkim analizama, procijenjen prividni klirens letermovira u stanju dinamičke ravnoteže nakon intravenske primjene doze od 480 mg primateljima HSCT-a iznosi 4,84 l/h.
English: The Non-Completer=Failure (NC=F) approach was used, where subjects who discontinued from the study prior to Week 24 post-transplant or had a missing outcome at Week 24 post-transplant were counted as failures.
Croatian: Non-Completer=Failure, NC=F), prema kojem se ispitanike koji su se povukli iz ispitivanja prije 24. tjedna nakon transplantacije ili za koje su nedostajali podaci o ishodu u 24. tjednu nakon transplantacije smatralo neuspješno liječenima.
English: The 240 mg tablets are packaged into a carton containing four (4) cardboard cards, each containing a 7-count Polyamide/Aluminium/PVC - Aluminium blister card for a total of 28 tablets.
Croatian: Tablete od 240 mg pakirane su u kutiju koja sadrži četiri (4) kartonske kartice, od kojih svaka sadrži poliamidnu/aluminijsku/PVC - aluminijsku blister karticu sa 7 tableta, ukupno 28 tableta.
English: Each 240 mg film-coated tablet contains less than 1 mmol sodium (23 mg).
Croatian: Jedna filmom obložena tableta od 240 mg sadrži manje od 1 mmol natrija (23 mg).
English: When PREVYMIS is co-administered with cyclosporine, the plasma concentrations of repaglinide is expected to increase due to the additional OATP1B inhibition by cyclosporine.
Croatian: Očekuje se da će pri istodobnoj primjeni lijeka PREVYMIS i ciklosporina koncentracije repaglinida u plazmi porasti zbog dodatne inhibicije OATP1B uzrokovane djelovanjem ciklosporina.
English: (primarily CYP3A inhibition and CYP2C8 inhibition or induction)
Croatian: (prvenstveno inhibicija CYP3A te inhibicija ili indukcija CYP2C8)
English: Favors Letermovir
Croatian: U korist letermovira
English: Incompatible intravenous bags and infusion set materials PREVYMIS concentrate for solution for infusion is incompatible with polyurethane-containing IV administration set tubing.
Croatian: Inkompatibilne infuzijske vrećice i infuzijski setovi PREVYMIS koncentrat za otopinu za infuziju inkompatibilan je s cijevima za intravensku primjenu koje sadrže poliuretan.
English: Marked increases in letermovir unbound exposure are anticipated in patients with moderate hepatic impairment combined with moderate or severe renal impairment (see section 4.2).
Croatian: Izraženo povećanje izloženosti nevezanom letermoviru očekuje se u bolesnika s umjerenim oštećenjem funkcije jetre koji uz to imaju i umjereno ili teško oštećenje funkcije bubrega (vidjeti dio 4.2).
English: The size of the induction effect is dependent on letermovir route of administration and whether cyclosporine is concomitantly used.
Croatian: Veličina indukcijskog učinka ovisi o putu primjene letermovira i o tome primjenjuje li se istodobno i ciklosporin.
English: ↓ phenytoin
Croatian: ↓ fenitoin
English: (P-gp induction)
Croatian: (indukcija P-gp-a)
English: PREVYMIS contains lactose
Croatian: PREVYMIS sadrži laktozu
English: Each 240 mg film-coated tablet contains 4 mg of lactose (as monohydrate).
Croatian: Jedna filmom obložena tableta od 240 mg sadrži 4 mg laktoze (u obliku hidrata).
English: Do not take PREVYMIS if:
Croatian: Nemojte uzimati PREVYMIS:
English: Frequent monitoring of tacrolimus whole blood concentrations should be performed during treatment, when changing PREVYMIS administration route, and at discontinuation of PREVYMIS and the dose of tacrolimus adjusted accordingly tacrolimus (5 mg single dose)/ letermovir (80 mg twice daily)
Croatian: Potrebno je često kontrolirati koncentracije takrolimusa u punoj krvi tijekom liječenja, kada se mijenja put primjene lijeka PREVYMIS i po prestanku liječenja lijekom PREVYMIS te sukladno njima prilagoditi dozu takrolimusa takrolimus (jedna doza od 5 mg)/letermovir (80 mg dvaput na dan)
English: • fentanyl - for severe pain
Croatian: • fentanil - koristi se za liječenje jake boli