FrancophonIA/ELRC3.0 huggingface dataset:
English: - if your doctor has told you that you have high or low levels of electrolytes such as potassium or magnesium in your blood.
Slovenian: če vam je zdravnik povedal, da imate v krvi visok ali nizek nivo elektrolitov, kot sta kalij ali magnezij,
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
Slovenian: V primeru sočasnega protivirusnega zdravljenja hepatitisa B ali C glejte tudi ustrezne Povzetke glavnih značilnosti teh zdravil.
English: However, as would be expected in this patient population, elevations in AST and ALT occurred more frequently than in the general HIV infected population.
Slovenian: Vendar so se po pričakovanju zvišanja AST in ALT pri tej skupini bolnikov pojavila pogosteje kot pri splošni populaciji bolnikov, okuženih z virusom HIV.
English: Pharmacotherapeutic group: Antiviral for systemic use, antivirals for treatment of HIV infections, combinations, ATC code: J05AR06.
Slovenian: Farmakoterapevtska skupina: zdravila za sistemsko zdravljenje virusnih infekcij, protivirusna zdravila za zdravljenje infekcij s HIV, kombinacije, oznaka ATC: J05AR06.
English: Stayed on original treatment regimen (N=97) n/N (%)
Slovenian: Bolniki, ki so ostali na prvotnem zdravljenju (N = 97) n/N (%)
English: Refer to the Summary of Product Characteristics for the medicinal product containing maraviroc.
Slovenian: Glejte Povzetke glavnih značilnosti zdravila, ki vsebuje maravirok.
English: Cross-resistance profiles for efavirenz, nevirapine and delavirdine in vitro demonstrated that the K103N substitution confers loss of susceptibility to all three NNRTIs.
Slovenian: Profili navzkrižne odpornosti na efavirenz, nevirapin in delavirdin in vitro so pokazali, da substitucija K103N povzroči izgubo občutljivosti za vse tri NNRTI.
English: As a general rule, it is recommended that HIV infected women do not breast-feed their infants in order to avoid transmission of HIV to the infant.
Slovenian: Na splošno je priporočljivo, da ženske, okužene z virusom HIV, ne dojijo, da se prepreči prenos virusa HIV na dojenčka.
English: Sertraline:
Slovenian: Sertralin:
English: As neural tube defects occur within the first 4 weeks of foetal development (at which time neural tubes are sealed), this potential risk would concern women exposed to efavirenz during the first trimester of pregnancy.
Slovenian: Ker do okvar nevralne cevi pride samo v prvih 4 tednih razvoja plodu (ko se nevralne cevi zaprejo), bi to potencialno tveganje zadevalo ženske, izpostavljene efavirenzu v prvem trimesečju nosečnosti.
English: In children whose mothers took NRTIs during pregnancy, the benefit from the protection against HIV outweighed the risk of side effects.
Slovenian: Pri otrocih, katerih matere so med nosečnostjo jemale nukleozidne zaviralce reverzne transkriptaze (NRTI), je korist zaščite pred virusom HIV odtehtala tveganje za neželene učinke.
English: Both the K65R and M184V/I mutation remain fully susceptible to efavirenz.
Slovenian: Tako mutacija K65R kot M184V/I pa ostajata popolnoma občutljivi za efavirenz.
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Slovenian: Bolnikom je treba svetovati, naj poiščejo zdravniško pomoč, če se pojavijo bolečine v sklepih, togost sklepov ali težave pri gibanju.
English: Tenofovir is primarily excreted by the kidneys by both filtration and an active tubular transport system with approximately 70 to 80% of the dose excreted unchanged in urine following intravenous administration.
Slovenian: Tenofovir se primarno izloča skozi ledvici tako z glomerulno filtracijo kot z aktivnim tubularnim transportnim sistemom, pri čemer se po intravenskem vnosu približno 70 do 80 % odmerka izloči nespremenjenega z urinom.
English: The oral bioavailability of tenofovir from tenofovir disoproxil in fasted patients was approximately 25%.
Slovenian: Peroralna biološka uporabnost tenofovirja iz dizoproksiltenofovirata pri teščih bolnikih je bila približno 25 %.
English: One tablet taken each day by mouth.
Slovenian: Priporočeni odmerek je: ena tableta na dan, ki jo zaužijete skozi usta.
English: The clinical outcome of this observed reduction of boceprevir trough concentrations has not been directly assessed.
Slovenian: Klinični izid tega opazovanega zmanjšanja najmanjše koncentracije boceprevira še ni bil neposredno ovrednoten.
English: 117 Allée Des Parcs, 69 800 Saint-Priest, France
Slovenian: 117 Allée Des Parcs, 69 800 Saint-Priest, Francija
English: - Independent of a history of liver disease, your doctor will consider regular blood tests to check how your liver is working.
Slovenian: - Neodvisno od tega, ali ste prej kdaj imeli jetrno bolezen, bo vaš zdravnik razmislil o rednih krvnih preiskavah, da preveri, kako delujejo vaša jetra.
English: Verapamil, Felodipine, Nifedipine and Nicardipine
Slovenian: Verapamil, felodipin, nifedipin in nikardipin
English: It is not considered to be causally associated with tenofovir disoproxil in the absence of this condition.
Slovenian: Ne obravnava se, kot da je vzročno povezana s dizoproksiltenofoviratom v odsotnosti tega stanja.
English: abnormal dreams, insomnia
Slovenian: nenormalne sanje, nespečnost
English: There were insufficient data to determine whether moderate or severe hepatic impairment (Child-Pugh-Turcotte Class B or C) affects efavirenz pharmacokinetics.
Slovenian: Ni bilo dovolj podatkov, da bi ugotovili, ali zmerna ali huda jetrna okvara (razreda B ali C po Child- PughTurcotteovi lestvici) vpliva na farmakokinetiko efavirenza.
English: These problems tend to occur more often in those who have a history of mental illness.
Slovenian: Te težave se pogosteje pojavijo pri bolnikih, ki so v preteklosti imeli duševno bolezen.
English: Patients should be advised that if they experience symptoms such as severe depression, psychosis or suicidal ideation, they should contact their doctor immediately to assess the possibility that the symptoms may be related to the use of efavirenz, and if so, to determine whether the risk of continued therapy outweighs the benefits (see section 4.8).
Slovenian: Bolnikom je treba svetovati, naj se v primeru pojava simptomov, kot so huda oblika depresije, psihoza ali misel na samomor, nemudoma posvetujejo s svojim zdravnikom, ki bo ocenil, ali so simptomi povezani z jemanjem efavirenza, in če je tako, odločil, ali je tveganje nadaljevanja zdravljenja z efavirenzom večje od koristi (glejte poglavje 4.8).
English: In other studies (prospective and cross-sectional), the most pronounced decreases in BMD were seen in patients treated with tenofovir disoproxil as part of a regimen containing a boosted protease inhibitor.
Slovenian: V drugih študijah (prospektivne in presečne) so najbolj izrazito zmanjšanje MGK opazili pri bolnikih, zdravljenih z dizoproksiltenofoviratom kot delom režima, ki je vseboval okrepljenega zaviralca proteaze.
English: • itchy rash to the skin caused by a reaction to sunlight
Slovenian: • srbeč kožni izpuščaj, ki ga povzroči reakcija na sončno svetlobo.
English: This medicine is available in plastic bottles containing a desiccant labelled ‘DO NOT EAT' and 30 tablets and in multipacks of 90 tablets comprising 3 bottles, each containing 30 tablets.
Slovenian: To zdravilo je na voljo v plastenkah s sušilnim sredstvom z oznako „DO NOT EAT“, ki vsebujejo 30 filmsko obloženih tablet in v skupnih pakiranjih z 90 filmsko obloženimi tabletami, ki vsebujejo 3 plastenke s 30 filmsko obloženimi tabletami.
English: Dihydroartemisinin (active metabolite):
Slovenian: Dihidroartemizinin (aktivni presnovek):
English: It contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni ‘'brez natrija''.
English: Rare completed suicide3,4, delusion3,4, neurosis3,4
Slovenian: Redki storjen samomor3,4, deluzija3,4, nevroza3,4
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Slovenian: Če opazite kakršne koli simptome okužbe ali druge simptome, na primer mišično oslabelost, oslabelost, ki se najprej pojavi v dlaneh in stopalih in nato širi proti trupu, palpitacije, tremor ali hiperaktivnost, zaradi potrebnega zdravljenja nemudoma obvestite zdravnika.
English: - signs of dizziness, difficulty sleeping, drowsiness, difficulty concentrating or abnormal dreaming.
Slovenian: - znake omotice, težave pri spanju, zaspanost, težave s koncentracijo ali nenormalne sanje.
English: Most cases occurred in patients who already had liver disease, but there have been a few reports in patients without any existing liver disease
Slovenian: Ta učinek se je pojavil večinoma pri bolnikih, ki so že imeli jetrno bolezen, vendar pa je bilo nekaj poročanj o pojavu pri bolnikih, ki prej niso imeli jetrne bolezni;
English: Skin and subcutaneous tissue disorders: Very common rash (moderate-severe, 11.6%, all grades, 18%)3
Slovenian: Bolezni kože in podkožja: Zelo pogosti izpuščaj (zmeren-hud, 11,6 %, vse stopnje, 18 %)3
English: Emtricitabine is primarily excreted by the kidneys with complete recovery of the dose achieved in urine (approximately 86%) and faeces (approximately 14%).
Slovenian: Emtricitabin se primarno izloča skozi ledvici - celoten odmerek se izloči z urinom (približno 86 %) in blatom (približno 14 %).
English: - Medicines used to lower blood fats (also called statins): Atorvastatin, pravastatin, simvastatin.
Slovenian: - Zdravila za znižanje količine maščob v krvi (imenovana tudi statini): atorvastatin, pravastatin, simvastatin.
English: These drugs include: - antiarrhythmics of classes IA and III, - neuroleptics, antidepressive agents, - certain antibiotics including some agents of the following classes: macrolides,
Slovenian: Med taka zdravila sodijo: - antiaritmiki razreda IA in III, - nevroleptiki, antidepresivi, - določeni antibiotiki, vključno z učinkovinami iz naslednjih razredov: makrolidi,
English: Rare osteomalacia (manifested as bone pain and infrequently contributing to fractures)2,4, myopathy2
Slovenian: Redki alacija (ki se kaže kot bolečine v kosteh in redko prispeva k zlomom)2,4, miopatija2
English: If you think you may have lactic acidosis, contact your doctor immediately.
Slovenian: Če menite, da imate laktacidozo, se takoj posvetujte s svojim zdravnikom.
English: In uninfected volunteers, multiple doses of 200 to 400 mg per day for 10 days resulted in a lower than predicted extent of accumulation (22 to 42% lower) and a shorter terminal half-life of 40 to 55 hours (single dose half-life 52 to 76 hours).
Slovenian: Pri neokuženih prostovoljcih so 10-dnevni večkratni odmerki 200-400 mg dnevno povzročili manjšo akumulacijo zdravila od pričakovane (za 22-42 % manjšo) in krajši končni razpolovni čas 40-55 ur (razpolovni čas enkratnega odmerka je 52-76 ur).
English: This medicinal product contains 7.5 mg of sodium metabisulfite per dose, which may rarely cause severe hypersensitivity reactions and bronchospasm.
Slovenian: To zdravilo vsebuje 7,5 mg natrijevega metabisulfita na odmerek, kar lahko redko povzroči hude preobčutljivostne reakcije in bronhospazem.
English: Mylan Hungary Kft Mylan utca 1, Komárom 2900, Hungary
Slovenian: Mylan Hungary Kft Mylan utca 1, Komárom 2900, Madžarska
English: - Medicines used to prevent organ transplant rejection (also called immunosuppressants), such as cyclosporine, sirolimus or tacrolimus.
Slovenian: - Zdravila za preprečevanje zavrnitve presajenih organov (imenovana tudi imunosupresivi), kakršna so ciklosporin, sirolimus ali takrolimus.
English: Laboratory tests should be performed to evaluate their liver disease at periodic intervals (see section 4.2).
Slovenian: Za ocenjevanje njihove jetrne bolezni je treba redno opravljati laboratorijske preiskave (glejte poglavje 4.2).
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se posvetujte z zdravnikom, preden vzamete to zdravilo.
English: Approximately 14 to 34% of a radiolabelled dose of efavirenz was recovered in the urine and less than 1% of the dose was excreted in urine as unchanged efavirenz.
Slovenian: Približno 14 do 34 % radioaktivno označenega odmerka efavirenza se je izločilo z urinom, manj kot 1 % odmerka pa se je z urinom izločilo v obliki nespremenjenega efavirenza.
English: - if you have a heart disorder, such as abnormal electrical signal called prolongation of the QT interval.
Slovenian: če imate bolezen srca, kot je nenormalen električni signal, kar se imenuje podaljšanje intervala QT.
English: - dry mouth - incoherent speech - increased appetite - libido decreased - myalgia
Slovenian: - suha usta - nepovezano govorjenje - povečan tek - zmanjšanje spolne sle - mialgija
English: Carbamazepine plasma levels should be monitored periodically.
Slovenian: Redno je treba spremljati koncentracije karbamazepina v plazmi.
English: Findings in the rat and monkey studies indicated that there was a substance-related decrease in intestinal absorption of phosphate with potential secondary reduction in BMD.
Slovenian: Ugotovitve študij pri podganah in opicah so pokazale, da je prišlo do z učinkovino povezanega zmanjšanja črevesne absorpcije fosfata s potencialnim sekundarnim zmanjšanjem BMD.
English: Reproductive toxicity studies in rats and rabbits showed no effects on mating, fertility, pregnancy or foetal parameters.
Slovenian: Študije vpliva na sposobnost razmnoževanja pri podganah in kuncih niso pokazale učinka na parjenje, plodnost, nosečnost ali parametre zarodka.
English: Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucosegalactose malabsorption should not take this medicine.
Slovenian: Bolniki z redkimi dednimi težavami, kot so intoleranca za galaktozo, skupno zmanjšanje aktivnosti laktaze ali malabsorpcija glukoze/galaktoze tega zdravila ne smejo jemati.
English: Genotoxicity studies revealed positive results in the in vitro mouse lymphoma assay, equivocal results in one of the strains used in the Ames test, and weakly positive results in an UDS test in primary rat hepatocytes.
Slovenian: Študije genotoksičnosti so pokazale pozitivne rezultate pri testu mišjega limfoma in vitro, dvoumne rezultate pri enem od sevov, ki so ga uporabili pri Amesovem testu, in šibko pozitivne rezultate pri testu UDS pri primarnih podganjih hepatocitih.
English: This may stop your medicines from working properly, or may make any side effects worse.
Slovenian: Zdravilu lahko preneha pravilno delovati ali pa se okrepijo neželeni učinki.
English: Interrupting treatment with efavirenz/emtricitabine/tenofovir disoproxil should also be considered in case of progressive decline of renal function when no other cause has been identified.
Slovenian: O prekinitvi zdravljenja z efavirenzom/emtricitabinom/dizoproksiltenofoviratom je treba razmisliti tudi v primeru progresivnega upada ledvične funkcije, če ni bil ugotovljen noben drug razlog.
English: EXP: Once opened use within 60 days.
Slovenian: EXP: Po odprtju porabiti v 60 dneh.
English: Cmin: ↑ 51% (↑ 37 to ↑ 66) Higher tenofovir concentrations could potentiate tenofovirassociated adverse events, including renal disorders.
Slovenian: Cmin: ↑ 51 % (↑ 37 do ↑ 66) Višje koncentracije tenofovirja bi lahko okrepile neželene učinke, povezane s tenofovirjem, vključno z motnjami delovanja ledvic.
English: This loss is due to significant decreases in elbasvir/grazoprevir plasma concentrations caused by CYP3A4 or P gp induction.
Slovenian: Ta izguba je posledica pomembnega zmanjšanja koncentracij elbasvirja/grazoprevirja v plazmi, ki jih povzroči indukcija CYP3A4 ali P-gp.
English: 1 Other efavirenz resistance mutations included A98G (n=1), K103E (n=1), V179D (n=1), and M230L (n=1).
Slovenian: 1 Druge mutacije za odpornost na efavirenz so vključevale A98G (n = 1), K103E (n = 1), V179D (n = 1) in M230L (n = 1).
English: Monitoring of renal function may be indicated, particularly in patients with underlying systemic or renal disease, or in patients taking nephrotoxic agents.
Slovenian: Spremljanje ledvične funkcije je lahko indicirano, zlasti pri blonikih z že obstoječo sistemsko ali ledvično boleznijo ali pri bolnikih, ki jemljejo nefrotoksična zdravila.
English: These findings should be considered for any child exposed in utero to nucleos(t)ide analogues, who present with severe clinical findings of unknown etiology, particularly neurologic findings.
Slovenian: Te ugotovitve je treba upoštevati pri vseh otrocih, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom, pri katerih se pojavijo resne klinične ugotovitve neznanega vzroka, zlasti nevrološke.
English: The frequency category was estimated from a statistical calculation based on the total number of patients treated with efavirenz in clinical trials (n = 3,969) or exposed to emtricitabine in randomised controlled clinical trials (n = 1,563) or exposed to tenofovir disoproxil in randomised controlled clinical trials and the expanded access programme (n = 7,319).
Slovenian: Kategorija pogostnosti je bila ocenjena s pomočjo statističnega izračuna na podlagi skupnega števila bolnikov, zdravljenih z efavirenzom v kliničnih preskušanjih (n = 3.969) ali izpostavljenih emtricitabinu v randomiziranih kontroliranih kliničnih preskušanjih (n = 1.563) ali izpostavljenih dizoproksiltenofoviratu v randomiziranih kontroliranih kliničnih preskušanjih in razširjenjem programu dostopa (n = 7.319).
English: Efavirenz may be an inducer of CYP2C19 and CYP2C9; however, inhibition has also been observed in vitro and the net effect of co-administration with substrates of these enzymes is not clear (see section 5.2).
Slovenian: Efavirenz je morda induktor encimov CYP2C19 in CYP2C9; vendar pa so in vitro opazili tudi zaviranje in neto učinek sočasne uporabe s substrati teh encimov ni razjasnjen (glejte poglavje 5.2).
English: As of July 2013, the Antiretroviral Pregnancy Registry (APR) has received prospective reports of 904 pregnancies with first trimester exposure to efavirenz-containing regimens, resulting in 766 live births.
Slovenian: Julija 2013 so v Registru nosečnosti za protiretrovirusna zdravila (Antiretroviral Pregnancy RegistryAPR) prejeli prospektivna poročila o 904 nosečnostih, pri katerih so bile ženske v prvem trimesečju v okviru zdravljenja izpostavljene efavirenzu, število živorojenih otrok pa je bilo 766.
English: Common cerebellar coordination and balance disturbances3, somnolence (2.0%)3, headache (5.7%)3, disturbance in attention (3.6%)3, dizziness dizziness headache
Slovenian: Pogosti cerebelarne motnje koordinacije in ravnotežja3, somnolenca (2,0 %)3, glavobol (5,7 %)3, motnje pozornosti (3,6 %)3, omotica (8,5 %)3
English: Exposures of raltegravir (a UGT1A1 substrate) are reduced in the presence of efavirenz (see section 4.5, Table 1).
Slovenian: Izpostavljenost raltegravirju (substratu UGT1A1) se v prisotnosti efavirenza zmanjša (glejte poglavje 4.5, tabela 1).
English: Emtricitabine (n=45)
Slovenian: Emtricitabin (n = 45)
English: McDermott Laboratories Limited t/a Gerard Laboratories t/a Mylan Dublin 35/36 Baldoyle Industrial Estate, Grange Road, Dublin 13 Ireland
Slovenian: McDermott Laboratories Limited t/a Gerard Laboratories t/a Mylan Dublin 35/36 Baldoyle Industrial Estate, Grange Road, Dublin 13 Irska
English: Rare renal failure (acute and chronic), acute tubular necrosis, nephritis (including acute interstitial nephritis)4, nephrogenic diabetes insipidus
Slovenian: Redki ledvična odpoved (akutna in kronična), akutna tubularna nekroza, nefritis, (vključno z akutnim intersticijskim nefritisom)4, nefrogeni diabetes insipidus
English: EXP Once opened use within 60 days.
Slovenian: EXP Po odprtju porabiti v 60 dneh.
English: The inducing effect of St. John's wort may persist for at least 2 weeks after cessation of treatment (see section 4.3).
Slovenian: Indukcijski učinek šentjanževke lahko traja vsaj še 2 tedna po prekinitvi zdravljenja (glejte poglavje 4.3).
English: 2 Thymidine analogue associated mutations included D67N (n=1) and K70R (n=1).
Slovenian: 2 Mutacije, povezane z analogom timidina (TAM = thymidine-analogue associated mutations), so vključevale D67N (n = 1) in K70R (n = 1).
English: - Medicines used to treat bacterial infections, including tuberculosis and AIDS-related mycobacterium avium complex: Clarithromycin, rifabutin, rifampicin.
Slovenian: - Zdravila za zdravljenje bakterijskih okužb, vključno s tuberkulozo in z AIDS-om povezanim kompleksom Mycobacterium avium: klaritromicin, rifabutin, rifampicin.
English: Clinically significant interactions are not expected as simeprevir and emtricitabine are eliminated via different pathways.
Slovenian: Klinično pomembnega medsebojnega delovanja ni pričakovati, saj se simeprevir in emtricitabin izločata po različnih poteh.
English: These patients should be carefully monitored for rises in viral load and, since the safety profile of efavirenz differs from that of protease inhibitors, for adverse reactions.
Slovenian: Pri teh bolnikih je treba skrbno nadzirati večanje virusnega bremena in neželene učinke, ker se profil varnosti efavirenza razlikuje od profila varnosti zaviralcev proteaz.
English: Patients who are receiving concomitant anticonvulsant medicinal products primarily metabolised by the liver, such as phenytoin, carbamazepine and phenobarbital, may require periodic monitoring of plasma levels.
Slovenian: Pri bolnikih, ki sočasno prejemajo antikonvulzive, ki se primarno presnavljajo v jetrih, kot so fenitoin, karbamazepin in fenobarbital, je morda potrebno redno spremljanje plazemske koncentracije.
English: - Sertraline, a medicine used to treat depression, as your doctor may need to change your dose of sertraline.
Slovenian: - Sertralin, zdravilo, ki se uporablja za zdravljenje depresije - zdravnik vam bo morda moral spremeniti odmerek sertralina.
English: Each film-coated tablet contains 7.5 mg of sodium metabisulfite and 105.5 mg of lactose monohydrate.
Slovenian: Ena filmsko obložena tableta vsebuje 7,5 mg natrijevega metabisulfita in 105,5 mg laktoze monohidrata.
English: In HIV infected patients, peak efavirenz plasma concentrations were attained by 5 hours and steadystate concentrations reached in 6 to 7 days.
Slovenian: Pri bolnikih, okuženih z virusom HIV, so bile največje koncentracije efavirenza v plazmi dosežene v 5 urah, dinamično ravnovesje koncentracije pa v 6 do 7 dneh.
English: Alternatives to clarithromycin (e.g. azithromycin) may be considered.
Slovenian: Morda bi bilo dobro razmisliti o možnosti uporabe alternativ za klaritromicin (npr. azitromicin).
English: Psychiatric disorders: Common depression (severe in 1.6%)3, anxiety3, abnormal dreams3, insomnia3
Slovenian: Psihiatrične motnje: Pogosti depresija (huda pri 1,6 %)3, anksioznost3, nenormalne sanje3, nespečnost3
English: Also, emtricitabine did not inhibit uridine 5'-diphosphoglucuronyl transferase, the enzyme responsible for glucuronidation.
Slovenian: Emtricitabin prav tako ni zaviral uridin-5'- difosfoglukuronil-transferaze, encima, ki je odgovoren za glukuronidacijo.
English: Cmax: ↔ 11% (CYP3A induction - effect on boceprevir) *0-8 hours
Slovenian: Cmax: ↔ 11 % (indukcija CYP3A - učinek na boceprevir) *0-8 ur
English: Phenytoin, Phenobarbital, and other anticonvulsants that are substrates of CYP isozymes
Slovenian: Fenitoin, fenobarbital in drugi antikonvulzivi, ki so substrati izocimov CYP
English: Resistance to efavirenz can be selected in vitro and resulted in single or multiple amino acid substitutions in HIV-1 RT, including L100I, V108I, V179D, and Y181C.
Slovenian: Odpornost proti efavirenzu se lahko selekcionira in vitro, kar je povzročilo enkratne ali večkratne substitucije aminokislin pri RT virusa HIV-1, vključno z L100I, V108I, V179D in Y181C.