FrancophonIA/ELRC3.0 huggingface dataset:
English: Telzir is a type of medicine known as an anti-retroviral.
Slovenian: Zdravilo Telzir spada med protiretrovirusna zdravila.
English: Subjects with >1 log10 change from baseline in plasma HIV1 RNA
Slovenian: Preiskovanci s spremembo HIV-1 RNA v plazmi od izhodišča > 1 log10
English: Each film-coated tablet contains 700 mg fosamprenavir as fosamprenavir calcium (equivalent to approximately 600 mg of amprenavir)
Slovenian: Ena filmsko obložena tableta vsebuje 700 mg fosamprenavirja v obliki kalcijeve soli fosamprenavirja (ustreza približno 600 mg amprenavirja).
English: 300 mg once daily
Slovenian: 600 mg enkrat dnevno
English: GlaxoSmithKline s.r.o.
Slovenian: Česká republika GlaxoSmithKline s.r.o.
English: No new safety concerns were identified from analyses of 48 week data from studies APV29005 or APV20002, in which 54 subjects 4 weeks to <2 years of age received twice daily fosamprenavir / ritonavir with background nucleoside reverse transcriptase inhibitor therapy and 5 subjects received only single doses of fosamprenavir with or without ritonavir.
Slovenian: V teh študijah je 54 preiskovancev, starih od 4 tedne do < 2 leti, prejemalo kombinacijo fosamprenavir/ritonavir dvakrat na dan in osnovno zdravljenje z zaviralcem nukleozidne reverzne transkriptaze, 5 preiskovancev pa je prejelo le enkraten odmerek fosamprenavirja, z ritonavirjem ali brez njega.
English: Ketoconazole 200 mg once daily for four days
Slovenian: 200 mg enkrat dnevno štiri dni itrakonazol
English: Close the bottle tightly with the cap.
Slovenian: Plastenko dobro zaprite s pokrovčkom.
English: No FPV/RTV drug interaction studies dasatinib: ↑ expected nilotinib: ↑ expected ibrutinib: ↑ expected vinblastine: ↑ expected everolimus: ↑ expected (CYP3A4 inhibition)
Slovenian: dasatinib:  pričakovano nilotinib:  pričakovano ibrutinib:  pričakovano vinblastin:  pričakovano everolimus:  pričakovano (inhibicija CYP3A4)
English: Subjects (%) with plasma HIV-1 RNA <50 copies/ml Subjects (%) with plasma HIV-1 RNA <400 copies/ml Subjects with >1 log10 change from baseline in plasma HIV1 RNA Change from baseline in CD4 cells (cells/µl)
Slovenian: > 100.000 kopij/ml, n (%) Mediano število celic CD4/µl Število celic CD4 < 350/µl, n (%) Rezultati učinkovitosti Bolniki s plazemsko HIV-1 RNA < 400 kopij/ml, momentna analiza Mediana sprememba števila celic CD4 od izhodišča (celic/µl), opazovana analiza
English: If you have moderate liver disease the dose is 9 ml Telzir oral suspension (450 mg fosamprenavir) twice daily with 100 mg ritonavir only once daily.
Slovenian: Če imate zmerno bolezen jeter, je odmerek 9 ml Telzir peroralne suspenzije (450 mg fosamprenavirja) dvakrat na dan s 100 mg ritonavirja le enkrat na dan.
English: For adults with moderate hepatic impairment (Child-Pugh score: 7-9) the recommended dose is 450 mg fosamprenavir (i.e. 9 ml Telzir oral suspension) twice daily with 100 mg ritonavir once daily.
Slovenian: Priporočeni odmerek za odrasle z zmerno jetrno okvaro (ocena po Child-Pugh-u: 7-9) je 450 mg fosamprenavirja (npr. 9 ml peroralne suspenzije Telzir) dvakrat na dan v kombinaciji z ritonavirjem v odmerku 100 mg enkrat na dan.
English: If you have mild liver disease, the dose is one Telzir tablet (700 mg) twice daily with 100 mg ritonavir only once daily.
Slovenian: Če imate blago bolezen jeter, je odmerek ena tableta zdravila Telzir (700 mg) dvakrat na dan s 100 mg ritonavirja le enkrat na dan.
English: B CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE
Slovenian: (ODGOVORNI9 ZA SPROŠČANJE SERIJE B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE
English: Each tablet contains 700 mg of fosamprenavir as fosamprenavir calcium (equivalent to approximately 600 mg amprenavir).
Slovenian: Ena tableta vsebuje 700 mg fosamprenavirja v obliki fosamprenavir, kalcijeve soli (ustreza približno 600 mg amprenavirja).
English: Propylene glycol
Slovenian: Okvaro ledvic
English: Children can take the adult dose of one 700 mg Telzir tablet twice daily (with ritonavir 100 mg twice daily) if they weigh at least 39 kg and can swallow the tablets whole.
Slovenian: Kot alternativa jemanju peroralne suspenzije Telzir Otroci lahko dobijo odmerek za odrasle - eno 700 mg tableto zdravila Telzir dvakrat na dan (in 100 mg ritonavirja dvakrat na dan) - če tehtajo vsaj 39 kg in lahko tablete pogoltnejo cele.
English: Push the plastic adapter into the neck of the bottle, while holding the bottle firmly.
Slovenian: Plastenko dobro primite in v vrat plastenke vstavite plastični nastavek.
English: If you have severe liver disease the dose is 6 ml Telzir oral suspension (300 mg fosamprenavir) twice daily with 100 mg ritonavir only once daily.
Slovenian: Če imate hudo bolezen jeter, je odmerek 6 ml Telzir peroralne suspenzije (300 mg fosamprenavirja) dvakrat na dan s 100 mg ritonavirja le enkrat na dan.
English: Amprenavir: AUC ↓ 82% Contraindicated (see section
Slovenian: amprenavir: AUC  82%
English: Lurasidone
Slovenian: lurazidon
English: Efavirenz 600 mg once daily
Slovenian: efavirenz 600 mg enkrat dnevno
English: A dosing syringe with a 10 ml graduation is supplied with the pack so you can measure your dose accurately.
Slovenian: Za natančno odmerjanje odmerka je pakiranju priložena na 10 ml umerjena odmerna brizga.
English: In adults, the oral suspension should be taken without food and on an empty stomach.
Slovenian: Odrasli morajo peroralno suspenzijo vzeti brez hrane in na prazen želodec.
English: Antiretroviral Experienced Adult Patients
Slovenian: Odrasli bolniki, ki so s protiretrovirusnimi zdravili predhodno že bili zdravljeni
English: If you are breast-feeding, or thinking about breast-feeding: →Talk to your doctor immediately.
Slovenian: Če dojite ali nameravate dojiti: →Nemudoma se posvetujte z zdravnikom.
English: FPV/RTV 700 mg/100 mg
Slovenian: LPV/RTV 400 mg/100 mg 2x/dan
English: The full prescribing information for ritonavir must therefore be consulted prior to initiation of therapy with Telzir with ritonavir.
Slovenian: Pred pričetkom zdravljenja z zdravilom Telzir v kombinaciji z ritonavirjem je tako potrebno natančno preveriti podatke o predpisovanju ritonavirja.
English: Results from studies with other HIV protease inhibitors and simeprevir or daclatasvir, suggest that coadministration with fosamprenavir/ritonavir is likely to lead to increased plasma exposures of simeprevir or daclatasvir due to CYP3A4 enzyme inhibition.
Slovenian: Rezultati študij z drugimi zaviralci proteaz HIV in paritaprevirjem/ritonavirjem/ombitasvirjem +/- dasabuvirjem kažejo, da sočasna uporaba fosamprenavirja/ritonavirja s paritaprevirjem/ritonavirjem/ombitasvirjem +/- dasabuvirjem verjetno poveča izpostavljenost paritaprevirju v plazmi zaradi zavrtja encima CYP3A4 in večjega odmerka ritonavirja.
English: Adults should take Telzir oral suspension without food and on an empty stomach.
Slovenian: Odrasli morajo peroralno suspenzijo zdravila Telzir jemati brez hrane in na prazen želodec.
English: Each ml of suspension contains 50 mg of fosamprenavir as fosamprenavir calcium salt (equivalent to approximately 43 mg of amprenavir).
Slovenian: En ml peroralne suspenzije vsebuje 50 mg fosamprenavirja v obliki kalcijeve soli fosamprenavirja (ustreza približno 43 mg amprenavirja).
English: Vardenafil
Slovenian: kvetiapin
English: Daclatasvir
Slovenian: midazolam
English: PDE5 inhibitors: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: PDE5 inhibitorji:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: • stiffness in the joints
Slovenian: • okorelost sklepov.
English: Potential for increased
Slovenian: Možnost za
English: (CYP3A4 inhibition by FPV/RTV)
Slovenian: (inhibicija CYP3A4 z FPV/RTV)
English: In subjects with moderate hepatic impairment (Child-Pugh score of 7-9), a reduced dose of fosamprenavir 450 mg twice daily with a reduced dosing frequency of ritonavir 100 mg once daily is predicted to deliver similar plasma amprenavir Cmax and AUC(0-12), but approximately 35 % lower plasma total amprenavir C12 values and approximately 88 % higher plasma unbound amprenavir C12 values than achieved in subjects with normal hepatic function receiving the standard fosamprenavir with ritonavir 700 mg / 100 mg twice daily regimen.
Slovenian: Pri osebah z zmerno jetrno okvaro (ocena po Child-Pugh-u 7-9) se predvideva, da bo nižji odmerek fosamprenavirja 450 mg dvakrat na dan v kombinaciji z manjšo pogostnostjo odmerjanja ritonavirja v odmerku 100 mg enkrat na dan zagotovil podobne plazemske vrednosti Cmax in AUC(0-12) amprenavirja, vendar pa približno 35 % nižje vrednosti C12 skupnega amprenavirja v plazmi in približno 88 % višje vrednosti C12 nevezanega amprenavirja v plazi kot pri osebah z normalnim delovanjem jeter pri standardnem režimu odmerjanja fosamprenavirja v kombinaciji z ritonavirjem 700 mg /100 mg dvakrat na dan.
English: ADRENORECEPTOR ANTAGONIST
Slovenian: ANTAGONISTI ALFA 1-ADRENERGIČNIH RECEPTORJEV
English: Insert the syringe firmly into the adapter.
Slovenian: V plastični nastavek čvrsto vstavite odmerno brizgo.
English: Subjects (%) with plasma HIV-1 RNA <50 copies/ml
Slovenian: Bolniki (%) s plazemsko HIV-1 RNA <50 kopij/ml
English: Rash (see text below “rash/cutaneous reactions”)
Slovenian: Stevens-Johnsonov sindrom angioedem eksantem (glejte besedilo v nadaljevanju “Eksantem/kožne reakcije”)
English: Also, some people have become diabetic while taking these medicines.
Slovenian: Med zdravljenjem s temi zdravili se je pri nekaterih bolnikih razvila sladkorna bolezen.
English: Children and adolescents: The adverse reaction profile in children and adolescents is based on integrated safety data from two studies (APV29005 Week 24 data and APV20003 Week 168 data [final data]) in which 158 HIV-1 infected subjects 2 to 18 years of age received fosamprenavir with ritonavir with background nucleoside reverse transcriptase inhibitor therapy (see section 5.1 for information on dosing regimens applied for each age group).
Slovenian: Otroci in mladostniki: Značilnosti neželenih učinkov pri otrocih in mladostnikih temeljijo na integriranih podatkih o varnosti iz dveh študij (APV29005 podatki 24. tedna in APV20003 podatki 168. tedna (končni podatki)).
English: All Subjects Baseline HIV-1 RNA < 100,000 copies/ml
Slovenian: Izhodiščna vrednost HIV-1 RNA < 100.000 kopij/ml
English: If you have mild liver disease, the dose is 14 ml Telzir oral suspension (700 mg fosamprenavir) twice daily with 100 mg ritonavir only once daily.
Slovenian: Če imate blago bolezen jeter, je odmerek 14 ml zdravila Telzir peroralna suspenzija (700 mg fosamprenavirja) dvakrat na dan s 100 mg ritonavirja le enkrat na dan.
English: Therapeutic concentration monitoring is recommended for tricyclic antidepressants (e.g. desipramine and nortriptyline) when co-administered with Telzir (see section 4.5).
Slovenian: Če se triciklični antidepresivi (npr. dezipramin in nortriptilin) dajejo sočasno z zdravilom Telzir, je priporočljivo nadzirati njihove terapevtske koncentracije (glejte poglavje 4.5).
English: Baseline Characteristics ART/PI status, n (%) ART-naïve ART-experienced, PI-naïve PI-experienced Median duration of prior ART exposure, weeks NRTI PI Median plasma HIV-1 RNA log10 copies/mL
Slovenian: IZHODIŠČNE ZNAČILNOSTI Stanje zdravljenja s protiretrovirusnimi zdravili/zaviralci proteaz, n (%) Še nezdravljeni s protiretrovirusnimi zdravili Že zdravljeni s protiretrovirusnimi zdravili, še nezdravljeni z zaviralci proteaz Že zdravljeni z zaviralci proteaz Mediano trajanje predhodne izpostavljenosti protiretrovirusnim zdravilom, tedni NRTI Zaviralci proteaz Mediana plazemska HIV-1 RNA log10 kopij/ml
English: These may affect up to 1 in 10 people:
Slovenian: Neželeni učinki, ki se lahko pojavijo pri do 1 od 10 bolnikov:
English: In subjects with severe hepatic impairment (Child-Pugh score of 10-13), a reduced dose of fosamprenavir 300 mg twice daily with a reduced dosing frequency of ritonavir 100 mg once daily delivered 19% lower plasma amprenavir Cmax, 23% lower AUC(0-12), and 38% lower C12 values, but similar unbound plasma amprenavir C12 values than achieved in subjects with normal hepatic function receiving the standard fosamprenavir with ritonavir 700 mg / 100 mg twice daily regimen.
Slovenian: Z manjšim odmerkom fosamprenavirja 300 mg dvakrat na dan in manj pogosto uporabo ritonavirja 100 mg enkrat na dan je bila pri osebah s hudo okvaro jeter (ocena po Child-Pughu 10-13) dosežena 19 % manjša Cmax amprenavirja v plazmi, 23 % manjša AUC(0-12) in 38 % manjša C12, a podobna C12 nevezanega plazemskega amprenavirja kot pri osebah z normalnim delovanjem jeter, ki so dobile standardno shemo fosamprenavirja z ritonavirjem 700 mg/100 mg dvakrat na dan.
English: For adults with mild hepatic impairment (Child-Pugh score: 5-6) the recommended dose is 700 mg fosamprenavir twice daily with 100 mg ritonavir once daily.
Slovenian: Priporočeni odmerek za odrasle z blago jetrno okvaro (ocena po Child-Pugh-u: 5-6) je 700 mg fosamprenavirja dvakrat na dan v kombinaciji z ritonavirjem v odmerku 100 mg enkrat na dan.
English: Children from 6 years of age and weighing less than 39 kg Use Telzir oral suspension.
Slovenian: Otroci od 6. leta starosti in s telesno maso manj kot 39 kg
English: amprenavir and raltegravir (especially in fed conditions) may result in virological
Slovenian: Opazili so pomembno zmanjšanje izpostavljenosti in Cmin tako za amprenavir kot za raltegravir; to lahko pri bolnikih (še posebno na poln želodec) povzroči virološko odpoved.
English: Subjects (%) with plasma HIV-1 RNA <400 copies/ml
Slovenian: Preiskovanci (%) s plazemsko HIV-1 RNA <400 kopij/ml
English: SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)
Slovenian: SEROTONINA (SSRIS)
English: For adults with moderate hepatic impairment (Child-Pugh score: 7-9) the recommended dose is 450 mg fosamprenavir twice daily with 100 mg ritonavir once daily.
Slovenian: Priporočeni odmerek za odrasle z zmerno jetrno okvaro (ocena po Child-Pugh-u: 7-9) je 450 mg fosamprenavirja dvakrat na dan v kombinaciji z ritonavirjem v odmerku 100 mg enkrat na dan.
English: Clinically validated phenotypic interpretation systems may be used in association with the genotypic data to estimate the activity of amprenavir / ritonavir or fosamprenavir / ritonavir in patients with PIresistant isolates.
Slovenian: Za ocenjevanje delovanja amprenavirja /ritonavirja ali fosamprenavirja /ritonavirja pri bolnikih z izolati, odpornimi na zaviralce proteaz, se lahko uporabijo klinično ovrednoteni fenotipski interpretacijski sistemi v kombinaciji z genotipskimi podatki.
English: The Summary of Product Characteristics of ritonavir must therefore be consulted prior to initiation of therapy with Telzir.
Slovenian: Preden se uvede zdravljenje z zdravilom Telzir, je potrebno preveriti povzetek glavnih značilnosti zdravila za ritonavir.
English: Resistant to FPV/RTV
Slovenian: Odporni proti FPV/RTV  4 mutacije iz rezultata
English: • The other ingredients are: hypromellose, sucralose, polysorbate 80, calcium chloride dihydrate,
Slovenian: • Pomožne snovi so: hipromeloza, sukraloza, polisorbat 80, kalcijev klorid dihidrat, umetna aroma žvečilnega gumija z okusom grozdja, naravna aroma poprove mete, prečiščena voda, propilenglikol, metilparahidroksibenzoat (E218) in propilparahidroksibenzoat (E216).
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING BOTTLE LABEL FOR TABLETS
Slovenian: NALEPKA ZA PLASTENKO S TABLETAMI
English: Telzir with ritonavir should be used with caution and at reduced doses in adults with mild, moderate, or severe hepatic impairment (see section 4.2).
Slovenian: Pri odraslih z blago, zmerno ali hudo jetrno okvaro je treba zdravilo Telzir v kombinaciji z ritonavirjem uporabljati previdno in odmerka zmanjšati (glejte poglavje 4.2).
English: Amiodarone: ↑ expected Bepridil: ↑ expected Quinidine: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: amiodaron bepridil kinidin flekainid propafenon amiodaron:  pričakovano bepridil:  pričakovano kinidin:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: (Modest induction of CYP3A4 by FPV/RTV)
Slovenian: (zmerna indukacija CYP3A4 z FPV/RTV)
English: You will be closely monitored if you are taking these medicines with Telzir/ritonavir:
Slovenian: Če boste naslednja zdravila jemali skupaj s kombinacijo Telzir/ritonavir, vas bo zdravnik skrbno nadziral:
English: • dolutegravir (used to treat HIV infection)
Slovenian: • dolutegravir (uporabljamo ga za zdravljenje okužbe z virusom HIV)
English: Amprenavir ↓ expected (CYP3A4 induction by St. John's wort)
Slovenian: amprenavir  pričakovano (indukcija CYP3A4 s šentjanževko)
English: For adult patients the fosamprenavir oral suspension should be taken without food and on an empty stomach.
Slovenian: Odrasli bolniki naj vzamejo peroralno suspenzijo fosamprenavirja brez hrane in na prazen želodec.
English: Baseline HIV-1 RNA ≥ 100,000 copies/ml
Slovenian: Izhodiščna vrednost HIV-1 RNA  100.000 kopij/ml
English: Diarrhoea
Slovenian: INFEKCIJE
English: Fluticasone propionate: ↑ Intrinsic cortisol levels: ↓
Slovenian: Intrinzična raven kortizola:
English: Fosamprenavir is rapidly and almost completely hydrolysed to amprenavir and inorganic phosphate as it is absorbed through the gut epithelium, following oral administration.
Slovenian: Po peroralnem vnosu se med absorpcijo preko črevesnega epitela fosamprenavir hitro in skoraj popolno hidrolizira v amprenavir in anorganski fosfat.
English: Recommendation concerning coadministration
Slovenian: Priporočila o sočasni uporabi drugih zdravil
English: You will be monitored while you are taking Telzir.
Slovenian: Med jemanjem zdravila Telzir boste pod rednim zdravniškim nadzorom.
English: There have been reports of increased bleeding including spontaneous skin haematomas and haemarthroses in haemophiliac patients type A and B treated with protease inhibitors (PIs).
Slovenian: Pri bolnikih s hemofilijo tipa A in B, ki so se zdravili z zaviralci proteaz (PI), so poročali o pogostnejših krvavitvah, vključno s spontanimi kožnimi hematomi in hemartrozami.
English: ANTIARRHYTHMICS
Slovenian: ANTIPSIHOTIKI
English: Common
Slovenian: Vsi
English: ORAL CONTRACEPTIVES Ethinyl estradiol 0.035 mg/norethisterone 0.5 mg once daily
Slovenian: etinilestradiol 0.035 mg/noretisteron 0.5 mg enkrat dnevno etinilestradiol: Cmax  28% etinilestradiol: AUC  37%
English: Telzir should be permanently discontinued in case of severe rash, or in case of rash of moderate intensity with systemic or mucosal symptoms (see section 4.8).
Slovenian: V primeru hudega eksantema ali v primeru eksantema zmerne intenzitete, ki ga spremljajo sistemski simptomi ali simptomi s strani sluznic, je potrebno uporabo zdravila Telzir trajno ukiniti (glejte poglavje 4.8).
English: Methyl parahydroxybenzoate (E218) Propyl parahydroxybenzoate (E216) Polysorbate 80
Slovenian: 6.1 Seznam pomožnih snovi hipromeloza sukraloza propilenglikol metilparahidroksibenzoat (E218) propilparahidroksibenzoat (E216) polisorbat 80 kalcijev klorid dihidrat umetna aroma žvečilnega gumija z okusom grozdja naravna aroma poprove mete prečiščena voda
English: No dosage adjustment of fosamprenavir or dolutegravir is recommended based on observed exposureresponse relationships of clinical data.
Slovenian: Glede na razmerje med izpostavljenostjo in odzivom, opaženim v kliničnih podatkih, prilagoditev odmerka fosamprenavirja ali dolutegravirja ni potrebna.
English: Telzir can make you feel dizzy and have other side effects that make you less alert.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Telzir lahko povzroči omotico in druge neželene učinke, ki lahko zmanjšajo zbranost.
English: Lovastatin: ↑ expected Simvastatin: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: lovastatin:  pričakovano simvastatin:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: Itraconazole: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: itrakonazol:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: Cisapride: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: cisaprid cisaprid:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: Anti-mycobacterial: Rifabutin
Slovenian: Učinkovine za zdravljenje infekcij z mikobakterijami rifabutin
English: Fosamprenavir with ritonavir therapy should be definitively stopped in case of severe rash or in case of rash of mild or moderate intensity associated with systemic or mucosal signs (see section 4.4).
Slovenian: V primeru hudega eksantema ali v primeru eksantema blage ali zmerne intenzitete, ki ga spremljajo sistemski simptomi ali simptomi s strani sluznic, je potrebno zdravljenje s fosamprenavirjem v kombinaciji z ritonavirjem trajno opustiti (glejte poglavje 4.4).
English: ORAL ANTICOAGULANTS
Slovenian: ANTIKONVULZIVI
English: Hypromellose
Slovenian: Hemofiliki
English: For children weighing less than 39 kg, Telzir oral suspension is the recommended option for the most accurate dosing in children based on body weight (please refer to the Summary of Product Characteristics for Telzir oral suspension).
Slovenian: Za otroke s telesno maso vsaj 39 kg, ki lahko pogoltnejo tablete, lahko uporabite odmerek za odrasle: 700 mg zdravila Telzir v tabletah dvakrat na dan in 100 mg ritonavirja dvakrat na dan. Za otroke s telesno maso manj kot 39 kg je priporočljivo izbrati peroralno suspenzijo Telzir, ker ta omogoča najnatančnejše odmerjanje glede na telesno maso (glejte povzetek glavnih značilnosti zdravila za peroralno suspenzijo Telzir).
English: (CYP3A4 induction by FPV/RTV)
Slovenian: (indukcija CYP3A4 z FPV/RTV)
English: Lopinavir: Cmax↑ 30% Lopinavir: AUC ↑ 37% Lopinavir: Cmin ↑ 52%
Slovenian: lopinavir / ritonavir 400 mg/100 mg dvakrat dnevno lopinavir: Cmax 30% lopinavir: AUC  37% lopinavir: Cmin  52%
English: Pimozide: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: pimozid pimozid:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: Lidocaine: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: lidokain:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: ritonavir and ombitasvir other HIV protease inhibitors and co-administered with and paritaprevir/ritonavir/ dasabuvir)
Slovenian: paritaprevir (formuliran z ritonavirjem in ombitasvirjem in sočasno uporabljen z dasabuvirjem)
English: In subjects with mild hepatic impairment (Child-Pugh score of 5-6), the dosage regimen of fosamprenavir 700 mg twice daily with a reduced dosing frequency of ritonavir 100 mg once daily provided slightly higher plasma amprenavir Cmax (17 %), slightly higher plasma amprenavir AUC(0-12) (22 %), similar plasma total amprenavir C12 values and approximately 117 % higher plasma unbound amprenavir C12 values compared to subjects with normal hepatic function receiving the standard fosamprenavir / ritonavir 700 mg /100 mg twice daily regimen.
Slovenian: Pri osebah z blago jetrno okvaro (ocena po Child-Pugh-u 5-6) so bile pri režimu odmerjanja fosamprenavir v odmerku 700 mg dvakrat na dan v kombinaciji z ritonavirjem v odmerku 100 mg enkrat na dan (manjša pogostnost odmerjanja ritonavirja) plazemske vrednosti Cmax in AUC(0-12) amprenavirja nekoliko višje, in sicer Cmax za 17 %, AUC(0-12) pa za 22 %.
English: Non-inferiority was demonstrated between fosamprenavir co-administered with ritonavir and lopinavir / ritonavir based on the proportions of patients achieving plasma HIV-1 RNA levels < 400 copies/ml at 48 weeks (primary endpoint).
Slovenian: Na osnovi odstotka bolnikov, pri katerih je bila v 48. tednu dosežena plazemska vrednost HIV-1 RNA  400 kopij/ml (primarni opazovani dogodek), je bilo dokazano, da je zdravljenje s fosamprenavirjem skupaj z ritonavirjem enakovredno zdravljenju s kombinacijo lopinavir/ritonavir.
English: In vivo a) ART-naïve or PI-naïve patients
Slovenian: In vivo a) Bolniki, ki se še niso zdravili s protiretrovirusnimi zdravili ali z zaviralci proteaz
English: Halofantrine: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: halofantrin:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: Etravirine AUC ↔a
Slovenian: a etravirin Cmin ↔
English: Erythromycin: ↑ expected (CYP3A4 inhibition by FPV/RTV)
Slovenian: eritromicin:  pričakovano (inhibicija CYP3A4 z FPV/RTV)
English: ORAL ANTICOAGULANTS Warfarin
Slovenian: Nenukleozidni zaviralci reverzne transkriptaze: efavirenz