FrancophonIA/ELRC3.0 huggingface dataset:
English: In a second study, patients with invasive candidiasis received daily doses of caspofungin at 50 mg/day (following a 70-mg loading dose on Day 1) or caspofungin at 150 mg/day (see section 4.8).
Croatian: U drugom ispitivanju bolesnici s invazivnom kandidijazom primali su kaspofungin u dnevnoj dozi od 50 mg/dan (nakon udarne doze od 70 mg 1. dana) ili 150 mg/dan (vidjeti dio 4.8).
English: The favourable response rate, by indication, at the end of caspofungin therapy was as follows in the MITT analysis: 81 % (30/37) in invasive candidiasis, 50 % (5/10) in invasive aspergillosis, and 100 % (1/1) in esophageal candidiasis.
Croatian: Prema MITT analizi stopa povoljnog odgovora na kraju terapije kaspofunginom prema indikaciji bila je prisutna u 81% (30/37) bolesnika s invazivnom kandidijazom, 50% (5/10) bolesnika s invazivnom aspergilozom i 100% (1/1) bolesnika s kandidijazom jednjaka.
English: • Feeling dizzy, decreased feeling or sensitivity (especially in the skin), shaking, feeling sleepy, change in the way things taste, tingling or numbness
Croatian: • Osjećaj omaglice, smanjeni osjet (osobito na koži), tresavica, osjećaj pospanosti, promjene osjeta okusa, trnci ili obamrlost
English: There were transient increases in liver ALT and AST of less than or equal to 3-fold the upper limit of normal (ULN) when caspofungin and cyclosporin were co-administered, that resolved with discontinuation of the medicinal products.
Croatian: Postojala su prolazna povišenja jetrenih ALT i AST čije su vrijednosti bile do 3 puta veće od gornje granice normale kad su se kaspofungin i ciklosporin primjenjivali istodobno, a nestala su prekidom primjene tih lijekova.
English: The concentrations of the reconstituted vials will be 5.2 mg/mL.
Croatian: Koncentracija rekonstituirane otopine u bočici iznosit će 5,2 mg/ml.
English: Caspofungin Accord makes fungal cells fragile and stops the fungus from growing properly.
Croatian: Caspofungin Accord djeluje na gljivice čineći njihovu staničnu stijenku krhkom i sprečavajući njihov rast.
English: • Flushing, hot flush, high blood pressure, low blood pressure, redness along a vein which is extremely tender when touched
Croatian: • Crvenilo uz osjećaj vrućine, navale vrućine, visok krvni tlak, nizak krvni tlak, crvenilo duž krvne žile koja je jako osjetljiva na dodir
English: * 10.5 mL should be used for reconstitution of all vials.
Croatian: * Sve bočice moraju se rekonstituirati pomoću volumena od 10,5 ml.
English: Pharmacokinetic data from one 10-month old child receiving the 50 mg/m2 daily dose indicated an AUC0-24 hr within the same range as that observed in older children and adults at the 50 mg/m2 and the 50 mg dose, respectively, while in one 6-month old child receiving the 50 mg/m2
Croatian: Farmakokinetički podaci jednog djeteta u dobi od 10 mjeseci, koje je primalo dozu od 50 mg/m2 na dan pokazali su da je AUC0-24 h bila u istom rasponu kao i u starije djece koja su primala 50 mg/m2 i odraslih koji su primali dozu od 50 mg, dok je u jednog šestomjesečnog djeteta, koje je primalo dozu od 50 mg/m2, AUC0-24 h bila nešto veća.
English: Nervous system disorders headache dizziness, dysgeusia, paraesthesia, somnolence, tremor, hypoaesthesia
Croatian: Poremećaji živčanog sustava glavobolja omaglica, disgeuzija, parestezije, somnolencija, tremor, hipoestezija
English: No dosage adjustment is necessary based on renal impairment (see section 5.2).
Croatian: Nije potrebno prilagođavati dozu zbog oštećenja funkcije bubrega (vidjeti dio 5.2).
English: Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2)
Croatian: Lijek se izdaje na ograničeni recept (vidjeti Dodatak I: Sažetak opisa svojstava lijeka, dio 4.2).
English: Step 1 Reconstitution of conventional vials
Croatian: Rekonstitucija uobičajenih bočica
English: • cough, serious breathing difficulties - if you are an adult and have invasive aspergillosis you may be experiencing a serious respiratory problem that could result in respiratory failure.
Croatian: • kašalj, ozbiljne poteškoće pri disanju - ako ste odrasla osoba i imate invazivnu aspergilozu,
English: In this group of patients, the safety of caspofungin at this higher dose appeared generally similar to patients receiving the 50-mg daily dose of caspofungin.
Croatian: U skupini bolesnika koja je primala kaspofungin u višoj dozi sigurnost primjene općenito se činila sličnom onoj u bolesnika koji su primali kaspofungin u dnevnoj dozi od 50 mg.
English: • Decreased flow of bile, enlarged liver, yellowing of the skin and/or whites of the eyes, liver injury caused by a drug or chemical, liver disorder
Croatian: • Smanjen protok žuči, povećana jetra, žuta boja kože i/ili bjeloočnica, kemijski uzrokovano oštećenje jetre, poremećaj jetre
English: 0.45 %, or 0.225 % Sodium Chloride solution for infusion or Lactated Ringers solution for infusion, not to exceed a final concentration of 0.5 mg/mL.
Croatian: 0,225% otopine natrijevog klorida za infuziju ili Ringerove otopine s laktatom za infuziju, s time da završna koncentracija ne smije biti veća od 0,5 mg/ml.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Intravenous use after reconstitution and dilution.
Croatian: 1 bočica NAČIN I PUT(EVI) PRIMJENE LIJEKA Za primjenu u venu nakon rekonstitucije i razrjeđivanja.
English: To reconstitute the powder, bring the vial to room temperature and aseptically add 10.5 mL of water for injection.
Croatian: Kako biste rekonstituirali prašak, zagrijte bočicu na sobnu temperaturu i u aseptičkim uvjetima dodajte 10,5 ml vode za injekciju.
English: Co-administration with inducers of metabolic enzymes Limited data suggest that an increase in the daily dose of caspofungin to 70 mg, following the 70 mg loading dose, should be considered when co-administering caspofungin in adult patients with certain inducers of metabolic enzymes (see section 4.5).
Croatian: Istodobna primjena s induktorima metaboličkih enzima Ograničeni podaci pokazuju da bi se moralo razmotriti povišenje dnevne doze kaspofungina na 70 mg nakon jednokratne udarne doze od 70 mg kad se kaspofungin u odraslih bolesnika primjenjuje istodobno s određenim induktorima metaboličkih enzima (vidjeti dio 4.5).
English: All adult drug-drug interaction studies described above were conducted at a 50 or 70 mg daily caspofungin dose.
Croatian: U svim ranije opisanim ispitivanjima interakcija lijekova u odraslih ispitanika korištena je doza kaspofungina od 50 mg ili 70 mg na dan.
English: If you have any further questions on the use of this medicine, ask your doctor, nurse or pharmacist.
Croatian: U slučaju bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se svom liječniku, medicinskoj sestri ili ljekarniku.
English: • you are already taking cyclosporin (used to help prevent organ transplant rejection or to suppress your immune system) - as your doctor may need to run extra blood tests during your treatment.
Croatian: • ako već primate ciklosporin (koristi se za sprečavanje odbacivanja presađenog organa ili kako bi se potisnuo Vaš imunološki sustav).
English: People who are at risk of getting a fungal infection include those who have just had an operation or those whose immune systems are weak.
Croatian: Osobe u kojih postoji rizik od gljivične infekcije uključuju osobe koje su nedavno operirane i osobe čiji je imunološki sustav oslabljen.
English: In lieu of breakpoints, Candida isolates that are susceptible to anidulafungin as well as micafungin should be considered susceptible to caspofungin.
Croatian: Što se tiče graničnih vrijednosti, izolati roda Candida koji su osjetljivi na anidulafungin, isto kao i na mikafungin trebaju se smatrati osjetljivima na kaspofungin.
English: Fungicidal activity with caspofungin has been demonstrated against Candida yeasts.
Croatian: Pokazalo se da kaspofungin ima fungicidno djelovanje protiv kvasaca roda Candida.
English: Volume of reconstituted Caspofungin Accord for transfer to intravenous bag or bottle
Croatian: Volumen rekonstituiranog lijeka Caspofungin Accord koji se dodaje u vrećicu ili bocu za intravensku infuziju
English: • Fast heart beat
Croatian: Ubrzani otkucaji srca
English: Do not use Caspofungin Accord
Croatian: Nemojte primjenjivati Caspofungin Accord
English: In clinical studies, caspofungin did not induce the CYP3A4 metabolism of other substances.
Croatian: U kliničkim ispitivanjima kaspofungin nije inducirao metaboličku razgradnju drugih tvari putem CYP3A4.
English: Invasive Candidiasis in Adult Patients: Two hundred thirty-nine patients were enrolled in an initial study to compare caspofungin and amphotericin B for the treatment of invasive candidiasis.
Croatian: Invazivna kandidijaza u odraslih bolesnika: u početno ispitivanje kojim su se uspoređivali kaspofungin i amfotericin B u liječenju invazivne kandidijaze bilo je uključeno 239 bolesnika.
English: White to off-white, powder.
Croatian: Bijeli do bjelkasti prašak.
English: Eligible patients had received chemotherapy for malignancy or had undergone hematopoietic stem-cell transplantation, and presented with neutropaenia (<500 cells/mm3 for 96 hours) and fever (>38.0°C)
Croatian: Odabrani bolesnici primali su kemoterapiju zbog maligne bolesti ili su im bile presađene krvotvorne matične stanice, a imali su neutropeniju (<500 stanica/mm3
English: not responding to ≥96 hours of parenteral antibacterial therapy.
Croatian: tijekom 96 sati) i vrućicu (>38,0°C) koje nisu odgovarale na parenteralnu antibakterijsku terapiju koja je trajala ≥96 sati.
English: Caspofungin Accord for transfer to intravenous bag or bottle
Croatian: Caspofungin Accord koji se dodaje u vrećicu ili bocu za intravensku infuziju
English: Development of in vitro resistance to caspofungin by Aspergillus species has been identified.
Croatian: Razvoj in vitro rezistencije vrsta roda Aspergillus na kaspofungin je istražen.
English: To reconstitute the powder bring the vial to room temperature and aseptically add 10.5 mL of water for injection.
Croatian: Kako biste rekonstituirali prašak zagrijte bočicu na sobnu temperaturu i u aseptičkim uvjetima dodajte 10,5 ml vode za injekciju.
English: • rash, skin peeling, mucous membrane sores, hives, large areas of peeling skin.
Croatian: • osip, guljenje kože, ranice na sluznici, koprivnjača, velika područja kože koja se guli.
English: Caspofungin displays moderate non-linear pharmacokinetics with increased accumulation as the dose is increased, and a dose dependency in the time to reach steady state upon multiple-dose administration.
Croatian: Farmakokinetika kaspofungina je umjereno nelinearna, pri čemu nakupljanje raste s porastom doze, a postizanje stanja dinamičke ravnoteže ovisi o dozi i vremenu nakon primjene višekratnih doza.
English: Caspofungin has been shown to cross the placental barrier in animal studies.
Croatian: U ispitivanjima na životinjama pokazalo se da kaspofungin prolazi placentalnu barijeru.
English: • cyclosporin or tacrolimus (used to help prevent organ transplant rejection or to suppress your immune system) as your doctor may need to run extra blood tests during your treatment
Croatian: • ciklosporin ili takrolimus (koriste se za sprečavanje odbacivanja presađenog organa ili za suzbijanje Vašeg imunološkog sustava).
English: cholestasis, hepatomegaly, hyperbilirubinaemia, jaundice, hepatic function abnormal, hepatotoxicity, liver disorder, gamma-glutamyltransferase increased
Croatian: kolestaza, hepatomegalija, hiperbilirubinemija, žutica, poremećena jetrena funkcija, hepatotoksičnost, poremećaj funkcije jetre, povišene vrijednosti gamaglutamiltransferaze
English: In a retrospective study of 40 patients treated during marketed use with caspofungin and cyclosporin for 1 to 290 days (median 17.5 days), no serious hepatic adverse reactions were noted (see section 4.4).
Croatian: U retrospektivnom ispitivanju nakon stavljanja lijeka u promet, koje je uključivalo 40 bolesnika istodobno liječenih kaspofunginom i ciklosporinom u trajanju od 1 do 290 dana (medijan 17,5 dana), nisu zabilježene nuspojave povezane s jetrom (vidjeti dio 4.4).
English: Response rates to caspofungin and liposomal amphotericin B for baseline infections caused by Aspergillus species were, respectively, 41.7 % (5/12) and 8.3 % (1/12), and by Candida species were 66.7 % (8/12) and 41.7 % (5/12).
Croatian: Stopa odgovora infekcija prouzročenih vrstama roda Aspergillus prisutnih na početku kliničkog ispitivanja na kaspofungin bila je 41,7% (5/12), a na liposomalni amfotericin B 8,3% (1/12), dok je stopa odgovora infekcija prouzročenih vrstama roda Candida na kaspofungin bila 66,7% (8/12), a na liposomalni amfotericin B 41,7% (5/12).
English: For all indications, a single 70-mg/m2 loading dose (not to exceed an actual dose of 70 mg) should be administered on Day 1, followed by 50 mg/m2 daily thereafter (not to exceed an actual dose of 70 mg daily).
Croatian: U svim se indikacijama prvog dana liječenja primjenjuje jednokratna udarna doza od 70 mg/m2 (ne smije biti viša od 70 mg na dan), a nakon toga nastavlja liječenje s dozom od 50 mg/m2 jedanput na dan (ne smije biti viša od 70 mg na dan).
English: • Chest discomfort, chest pain, feeling of body temperature change, generally feeling unwell, general pain, swelling of the face, swelling of the ankles, hands or feet, swelling, tenderness, feeling tired.
Croatian: • Nelagoda u prsima, bol u prsima, osjećaj promjene tjelesne temperature, opće loše osjećanje, bolovi, oticanje lica, oticanje zglobova, ruku ili nogu, oticanje, osjetljivost, osjećaj umora.
English: Alternatively, the volume (mL)c of reconstituted Caspofungin Accord can be added to a reduced volume of 0.9 %, 0.45 %, or 0.225 % Sodium Chloride solution for infusion or Lactated Ringers solution for infusion, not to exceed a final concentration of 0.5 mg/mL.
Croatian: Alternativno možete dodati volumen (ml)c rekonstituiranog lijeka Caspofungin Accord u smanjeni volumen 0,9%, 0,45% ili 0,225% otopine natrijevog klorida za infuziju ili Ringerove otopine s laktatom za infuziju, s time da završna koncentracija ne smije biti veća od 0,5 mg/ml.
English: Paediatric Patients
Croatian: Pedijatrijski bolesnici
English: Remove the volume of medicinal product equal to the calculated daily maintenance dose (Step 1) from the vial.
Croatian: Izvucite iz bočice volumen lijeka jednak izračunatoj dnevnoj dozi održavanja (Korak 1).
English: 35 mg for moderate hepatic impairment (from one 50 mg vial) at reduced volume
Croatian: 35 mg pri umjerenom oštećenju funkcije jetre (iz jedne bočice od 50 mg) pri smanjenom volumenu
English: • Back pain, pain in an arm or leg, bone pain, muscle pain, muscle weakness
Croatian: • Bolovi u leđima, bolovi u rukama i nogama, bolovi u kostima, bolovi u mišićima, slabost mišića
English: • Blurred vision, increase in tears, swollen eyelid, yellowing of the whites of the eyes
Croatian: • Zamagljen vid, pojačano suzenje, otečeni kapci, žutilo bjeloočnica
English: If you have been given more Caspofungin Accord than you should
Croatian: Akoprimite više lijeka Caspofungin Accord nego što ste trebali
English: • Changes in some laboratory blood tests (including disease of blood clotting, platelets, red blood cells and white blood cells)
Croatian: • Promjene nekih laboratorijskih krvnih testova (uključujući i bolest zgrušavanja krvi, trombocita,
English: a The white to off-white cake will dissolve completely.
Croatian: Bijeli do bjelkasti kompaktni prašak potpuno će se otopiti.
English: In patients weighing more than 80 kg, after the initial 70 mg loading dose, caspofungin 70 mg daily is recommended (see section 5.2).
Croatian: U bolesnika težih od 80 kg preporučuje se nakon početne udarne doze od 70 mg nastaviti s dozom od 70 mg kaspofungina jedanput na dan (vidjeti dio 5.2).
English: Developmental toxicity studies in rats showed that caspofungin caused decreases in foetal body weights and an increase in the incidence of incomplete ossification of vertebra, sternebra, and skull bone at doses of 5 mg/kg that were coupled to adverse maternal effects such as signs of histamine release in pregnant rats.
Croatian: Ispitivanja razvojne toksičnosti kaspofungina kod štakora pokazala su da kaspofungin izaziva gubitak fetalne tjelesne težine i povišenje incidencije nedovršenog okoštavanja kralježaka, segmenata prsne kosti i kostiju lubanje pri dozama od 5 mg/kg.
English: (maximum 70 mg daily), the caspofungin plasma AUC0-24 hr after multiple doses was comparable to that seen in adults receiving caspofungin at 50 mg daily and to that in older children (2 to 11 years of age) receiving the 50 mg/m2 daily dose.
Croatian: (maksimalno 70 mg na dan), AUC0-24 h kaspofungina u plazmi nakon višekratnih doza bila je usporediva s onom izmjerenom u odraslih koji su primali kaspofungin u dozi od 50 mg na dan i onom u starije djece (u dobi od 2 do 11 godina) koja su primala dozu od 50 mg/m2 na dan.
English: What Caspofungin Accord contains
Croatian: Što Caspofungin Accord sadrži
English: There were 1,095 patients included in the primary Modified Intention-To-Treat (MITT) efficacy analysis of overall favourable response; caspofungin (33.9 %) was as effective as liposomal amphotericin B (33.7 %) [% difference 0.2 (95.2 % CI -5.6, 6.0)].
Croatian: MITT) ukupnog povoljnog odgovora uključila je 1095 bolesnika; kaspofungin (33,9%) je bio jednako djelotvoran kao i liposomalni amfotericin B (33,7%) [% razlika 0,2 (95,2 % CI -5,6, 6,0)].
English: If any of the above apply to you (or you are not sure), talk to your doctor, nurse or pharmacist before you are given Caspofungin Accord.
Croatian: Ako se nešto od gore navedenog odnosi na Vas (ili ako niste sigurni) obratite se svom liječniku, medicinskoj sestri ili ljekarniku prije nego primite Caspofungin Accord .
English: The study compared caspofungin at 50 mg daily (following a 70-mg loading dose on Day 1) versus 150 mg daily in the treatment of invasive candidiasis.
Croatian: U ispitivanju je uspoređivana doza kaspofungina od 50 mg na dan (nakon udarne doze od 70 mg prvog dana) s dozom od 150 mg na dan u liječenju invazivne kandidijaze.
English: Blood and lymphatic system disorders haemoglobin decreased, haematocrit decreased, white blood cell count decreased anaemia, thrombocytopaenia, coagulopathy, leukopaenia, eosinophil count increased, platelet count decreased, platelet count increased, lymphocyte count decreased, white blood cell count increased, neutrophil count decreased
Croatian: Poremećaji krvi i limfnog sustava snižen hemoglobin, snižen hematokrit, smanjeni broj leukocita anemija, trombocitopenija, koagulopatija, leukopenija, povećani broj eozinofila, smanjeni broj trombocita, povećani broj trombocita, smanjeni broj limfocita, povećani broj leukocita, smanjeni broj neutrofila
English: The favourable overall response rates at the end of caspofungin therapy were similar in the 2 treatment groups: 72 % (73/102) and 78 % (74/95) for the caspofungin 50-mg and 150-mg treatment groups, respectively (difference 6.3 % [95 % CI -5.9, 18.4]).
Croatian: Povoljna ukupna stopa odgovora na kraju terapije kaspofunginom bila je slična u te 2 terapijske skupine: 72% (73/102) u skupini koja je primala kaspofungin u dozi od 50 mg i 78% (74/95) u skupini koja je primala kaspofungin u dozi od 150 mg (razlika 6,3% [95% CI, -5,9, 18,4]).
English: Each vial of Caspofungin Accord contains 50 mg or 70 mg of caspofungin (as acetate).
Croatian: Jedna bočica lijeka Caspofungin Accord sadrži 50 ili 70 mg kaspofungina (u obliku kaspofunginacetata).
English: An initial 70 mg loading dose should be administered on Day-1.
Croatian: Prvog dana mora se primijeniti početna udarna doza od 70 mg.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Caspofungin Accord 50 mg powder for concentrate for solution for infusion Each vial contains 50 mg caspofungin (as acetate).
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Caspofungin Accord 50 mg prašak za koncentrat za otopinu za infuziju Jedna bočica sadrži 50 mg kaspofungina (u obliku kaspofunginacetata).
English: • Catheter site pain, injection site complaints (redness, hard lump, pain, swelling, irritation, rash, hives, leaking of fluid from the catheter into the tissue), inflammation of vein at injection site
Croatian: • Bol na mjestu katetera, znakovi na mjestu injekcije (crvenilo, tvrdi otok, bol, oticanje, nadraženost, osip, koprivnjača, curenje tekućine iz katetera u tkivo), upala vene na mjestu injekcije
English: Refractoriness is defined as progression of infection or failure to improve after a minimum of
Croatian: Izostanak odgovora na liječenje definira se kao napredovanje infekcije ili izostanak poboljšanja nakon najmanje 7 dana uzimanja terapijskih doza učinkovite antifungalne terapije.
English: Aseptically transfer this volume (mL)c of reconstituted Caspofungin Accord to an IV bag (or bottle) containing 250 mL of 0.9 %, 0.45 %, or 0.225 % Sodium Chloride solution for infusion or Lactated Ringers solution for infusion.
Croatian: U aseptičkim uvjetima prenesite taj volumen (ml)c rekonstituiranog lijeka Caspofungin Accord u vrećicu (ili bocu) za i.v. primjenu koja sadrži 250 ml 0,9%, 0,45% ili 0,225% otopine natrijevog klorida za infuziju ili Ringerovu otopinu s laktatom za infuziju.
English: This reconstituted solution may be stored for up to 24 hours at or below 25°C.
Croatian: Rekonstituirana otopina može se čuvati do 24 sata pri temperaturi od 25°C ili nižoj.
English: There is no clinical experience in adults with severe hepatic impairment or in paediatric patients with any degree of hepatic impairment.
Croatian: Ne postoji kliničko iskustvo u bolesnika s teškim oštećenjem funkcije jetre, kao ni u pedijatrijskih bolesnika s bilo kojim stupnjem oštećenja jetre.
English: General disorders and administration site conditions pyrexia, chills, infusion-site pruritus pain, catheter site pain, fatigue, feeling cold, feeling hot, infusion site erythema, infusion site induration, infusion site pain, infusion site swelling, injection site phlebitis, oedema peripheral, tenderness, chest discomfort, chest pain, face oedema, feeling of body temperature change, induration, infusion site extravasation, infusion site irritation, infusion site phlebitis, infusion site rash, infusion site urticaria, injection site erythema, injection site oedema, injection site pain, injection site swelling, malaise, oedema
Croatian: Opći poremećaji i reakcije na mjestu primjene vrućica, zimica, pruritus na mjestu infuzije bol, bol na mjestu katetera, umor, osjećaj hladnoće, osjećaj vrućine, eritem na mjestu infuzije, induracija na mjestu infuzije, bol na mjestu infuzije, oticanje na mjestu infuzije, flebitis na mjestu injekcije, periferni edem, osjetljivost, nelagoda u prsištu, bol u prsištu, edem lica, osjećaj promjene tjelesne temperature, induracija, ekstravazacija na mjestu infuzije, nadraženost na mjestu infuzije, flebitis na mjestu infuzije, osip na mjestu infuzije, urtikarija na mjestu infuzije, eritem na mjestu injekcije, edem na mjestu injekcije, bol na mjestu injekcije, oticanje na mjestu injekcije, malaksalost, edem
English: This is because it does not contain any ingredients to stop the growth of bacteria.
Croatian: Pripremljeni Caspofungin Accord mora se odmah primijeniti jer ne sadrži sastojke koji bi zaustavili rast bakterija.
English: A single 70 mg loading dose should be administered on Day-1, followed by 50 mg daily thereafter.
Croatian: Prvog dana liječenja potrebno je primijeniti jednokratnu udarnu dozu od 70 mg, a nakon toga nastaviti s dozom od 50 mg jedanput na dan.
English: Musculoskeletal and connective tissue disorders arthralgia back pain, pain in extremity, bone pain, muscular weakness, myalgia
Croatian: Poremećaji mišićnokoštanog sustava i vezivnog tkiva artralgija bol u leđima, bol u udovima, bol u kostima, slabost mišića, mialgija
English: Invasive Aspergillosis in Adult Patients: Sixty-nine adult patients (age 18-80) with invasive aspergillosis were enrolled in an open-label, non-comparative study to evaluate the safety, tolerability, and efficacy of caspofungin.
Croatian: Invazivna aspergiloza u odraslih bolesnika: u otvoreno, nekomparativno ispitivanje, u kojem je procjenjivana sigurnost primjene, podnošljivost i djelotvornost kaspofungina bilo je uključeno 69 odraslih (u dobi od 18 do 80 godina) bolesnika s invazivnom aspergilozom.