FrancophonIA/ELRC3.0 huggingface dataset:
English: There have been post-marketing reports of pancreatitis in paediatric patients.
Slovenian: V obdobju trženja zdravila so pri pediatričnih bolnikih poročali o primerih pankreatitisa.
English: Voriconazole is a broad spectrum, triazole antifungal agent and is indicated in adults and children aged 2 years and above as follows:
Slovenian: Vorikonazol je širokospektralen triazolski antimikotik, indiciran pri odraslih in otrocih, starih 2 leti ali več, za:
English: When the Voriconazole Hikma infusion is complete, the line may be used for administration of other intravenous products.
Slovenian: Ko je infuzija zdravila Vorikonazol Hikma končana, se lahko linija uporabi za dajanje drugih intravenskih pripravkov.
English: The median duration of study drug prophylaxis was 96 days for voriconazole and 68 days for itraconazole in the MITT group.
Slovenian: V skupini MITT je bila mediana trajanja študije profilakse pri vorikonazolu 96 dni, pri itrakonazolu pa 68 dni.
English: 4 Includes hypoxic-ischaemic encephalopathy and metabolic encephalopathy.
Slovenian: 4 Vključuje hipoksično-ishemično encefalopatijo in presnovno encefalopatijo.
English: Serum creatinine levels should be closely monitored in these patients and, if increases occur, consideration should be given to changing to oral voriconazole therapy (see section 5.2).
Slovenian: Pri teh bolnikih je treba skrbno nadzirati kreatinin v serumu; če se zviša, je treba razmisliti o prehodu na peroralno zdravljenje z vorikonazolom (glejte poglavje 5.2).
English: Pharmacokinetic-Pharmacodynamic analyses of clinical trial data identified positive associations between plasma voriconazole concentrations and both liver function test abnormalities and visual disturbances.
Slovenian: Farmakokinetično-farmakodinamične analize podatkov iz kliničnih preskušanj so odkrile pozitivno povezavo med koncentracijo vorikonazola v plazmi ter nenormalnostmi testov jetrne funkcije in motnjami vida.
English: • Treatment of candidaemia in non-neutropenic patients
Slovenian: • zdravljenje kandidemije pri nenevtropeničnih bolnikih
English: Cerebrospinal fluid samples from eight patients in a compassionate programme showed detectable voriconazole concentrations in all patients.
Slovenian: V vzorcih cerebrospinalne tekočine osmih bolnikov v programu sočutne uporabe je bila koncentracija vorikonazola merljiva pri vseh bolnikih.
English: If you are already being treated with rifabutin, your blood counts and side effects to rifabutin will need to be monitored.
Slovenian: Če se že zdravite z rifabutinom, bo treba nadzirati vašo krvno sliko in neželene učinke rifabutina.
English: • Indinavir and other HIV protease inhibitors (used for treating HIV)
Slovenian: • indinavir oz. druge zaviralce proteaze HIV (uporabljajo se za zdravljenje okužbe s HIV)
English: When multiple doses of voriconazole are administered with high fat meals, Cmax and AUCτ are reduced by 34 % and 24 %, respectively.
Slovenian: Če se večkratne odmerke vorikonazola uporablja z zelo mastnimi obroki, se Cmax zmanjša za 34 % in AUCτ za 24 %.
English: A comparison of the paediatric and adult population pharmacokinetic data indicated that the predicted total exposure (AUCτ) in children following administration of a 9 mg/kg IV loading dose was comparable to that in adults following a 6 mg/kg IV loading dose.
Slovenian: Primerjava podatkov populacijske farmakokinetike pediatrične in odrasle populacije kaže, da je bila pričakovana celokupna izpostavljenost (AUCτ) pri otrocih po uporabi 9 mg/kg intravenskega polnilnega odmerka primerljiva s tisto pri odraslih po uporabi 6 mg/kg intravenskega polnilnega odmerka.
English: Based on the population pharmacokinetic analysis, 12- to 14year-old adolescents weighing less than 50 kg should receive children's doses (see section 4.2).
Slovenian: Na osnovi populacijske farmakokinetične analize morajo bolniki, stari od 12 do 14 let, s telesno maso manj kot 50 kg, prejemati odmerke za otroke (glejte poglavje 4.2).
English: If any side effects occur, most are likely to be minor and temporary.
Slovenian: Če se kakršni koli neželeni učinki sploh pojavijo, so običajno blagi in prehodni.
English: • Small dry scaly skin patches, sometimes thick with spikes or ‘horns'
Slovenian: • majhni, suhi, luskasti predeli kože, včasih odebeljeni in s koničastimi izrastki ali ''rogovi''
English: Nine subjects in the voriconazole group and five in the amphotericin B followed by fluconazole group also had mycologically proven infection in deep tissue.
Slovenian: Devet preskušancev v skupini z vorikonazolom in 5 v skupini z amfotericinom B/flukonazolom je imelo tudi mikološko dokazano okužbo v globokem tkivu.
English: Reconstitute and dilute before use - see leaflet.
Slovenian: Pred uporabo rekonstituirajte in razredčite - glejte navodilo za uporabo!
English: Voriconazole Hikma treatment will continue for as long as your doctor advises, however the duration of treatment with voriconazole should be no more than 6 months.
Slovenian: Zdravljenje z zdravilom Vorikonazol Hikma se bo nadaljevalo, dokler bo zdravnik menil, da je potrebno, vendar pa zdravljenje s praškom za raztopino za infundiranje ne sme trajati več kot 6 mesecev.
English: Voriconazole was administered intravenously with a loading dose of 6 mg/kg every 12 hours for the first 24 hours followed by a maintenance dose of 4 mg/kg every 12 hours for a minimum of seven days.
Slovenian: Vorikonazol so dajali intravensko s polnilnim odmerkom 6 mg/kg vsakih 12 ur prvih 24 ur, nato je sledil vzdrževalni odmerek 4 mg/kg vsakih 12 ur najmanj 7 dni.
English: Voriconazole is rapidly and almost completely absorbed following oral administration, with maximum plasma concentrations (Cmax) achieved 1-2 hours after dosing.
Slovenian: Vorikonazol se po peroralni uporabi hitro in skoraj popolnoma absorbira in doseže največjo koncentracijo v plazmi (C max) 1 do 2 uri po zaužitju.
English: Recommendations concerning co-administration
Slovenian: Priporočila glede sočasne uporabe
English: Patients should be monitored for the development of abnormal renal function.
Slovenian: Bolnike je treba nadzorovati, da bi odkrili nenormalno delovanje ledvic.
English: The required volume of the reconstituted concentrate is then added to a recommended compatible infusion solution listed below to obtain a final Voriconazole Hikma solution containing 0.5 to 5 mg/ml of voriconazole.
Slovenian: Potrebni volumen pripravljenega koncentrata se nato doda eni od priporočenih združljivih infuzijskih raztopin, naštetih spodaj, da nastane končna raztopina zdravila Vorikonazol Hikma , ki vsebuje od 0,5 do 5 mg/ml vorikonazola.
English: Investigations blood creatinine increased blood urea increased, blood cholesterol increased
Slovenian: Preiskave zvišanje ravni kreatinina v krvi zvišanje ravni sečnine v krvi, zvišanje ravni holesterola v krvi
English: Your doctor may change your dose depending upon your condition.
Slovenian: Morda bo spremenil odmerek za vas glede na vaše splošno stanje.
English: The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of voriconazole.
Slovenian: Kopičenje 14α-metil sterolov korelira s posledično izgubo ergosterola v celični membrani glive in je lahko odgovorno za antimikotično delovanje vorikonazola.
English: Undesirable effects reported in subjects receiving voriconazole:
Slovenian: Neželeni učinki, opisani pri preskušancih, ki so prejemali vorikonazol:
English: • Non-nucleoside reverse transcriptase inhibitors (e.g., efavirenz, delavirdine, nevirapine) (used for treating HIV) (some doses of efavirenz can NOT be taken at the same time as Voriconazole Hikma)
Slovenian: • nenukleozidne zaviralce reverzne transkriptaze (npr. efavirenz, delavirdin, nevirapin) (uporabljajo se za zdravljenje okužbe s HIV) (določenih odmerkov efavirenza se NE sme vzeti sočasno z zdravilom Vorikonazol Hikma)
English: In clinical trials, 705 patients received voriconazole therapy for greater than 12 weeks, with 164 patients receiving voriconazole for over 6 months.
Slovenian: Trajanje zdravljenja V kliničnih preskušanjih je 705 bolnikov dobivalo vorikonazol več kot 12 tednov, 164 pa več kot 6 mesecev.
English: Photosensitivity reactions, such as ephelides, lentigo and actinic keratosis, have been reported, especially during long-term therapy (see section 4.4).
Slovenian: Opisane so bile fotosenzitivnostne reakcije kot so efelide, lentigo ter aktinična keratoza,, zlasti med dolgotrajnim zdravljenjem (glejte poglavje 4.4).
English: Depending on your response to treatment, your doctor may decrease the dose to 3 mg/kg twice daily.
Slovenian: Glede na vaš odziv na zdravljenje zdravnik lahko zmanjša odmerek na 3 mg/kg dvakrat na dan.
English: R-methadone (active) Cmax ↑ 31% R-methadone (active) AUCτ ↑ S-methadone Cmax ↑ 65% S-methadone AUCτ ↑ 103%
Slovenian: R-metadon (aktivni) Cmax ↑ 31% R-metadon (aktivni) AUCτ ↑ 47% S-metadon Cmax ↑ 65% S-metadon AUCτ ↑ 103%
English: As the half-life of alfentanil is prolonged in a 4-fold manner when alfentanil is coadministered with voriconazole and in an independent published study, concomitant use of voriconazole with fentanyl resulted in an increase in the mean AUC 0-∞ of fentanyl, frequent monitoring for opiate-associated adverse reactions (including a longer respiratory monitoring period) may be necessary.
Slovenian: Razpolovni čas alfentanila se ob sočasni uporabi z vorikonazolom 4-krat podaljša, v objavljeni neodvisni študiji pa je imela sočasna uporaba vorikonazola skupaj s fentanilom za posledico povečanje povprečne vrednosti AUC 0-∞ fentanila, zato utegne biti potreben pogostejši nadzor z opiati povezanih neželenih učinkov (vključno z daljšim obdobjem respiratornega nadzora).
English: No subject experienced an interval exceeding the potentially clinically relevant threshold of 500 msec.
Slovenian: Pri nobenem izmed preskušancev interval ni presegel potencialno klinično pomembnega praga 500 milisekund.
English: In vivo studies indicated that CYP2C19 is significantly involved in the metabolism of voriconazole.
Slovenian: Študije in vivo nakazujejo, da je CYP2C19 pomembno vpleten v presnovo vorikonazola.
English: The studies included cerebral, sinus, pulmonary and disseminated aspergillosis in patients with bone marrow and solid organ transplants, haematological malignancies, cancer and AIDS.
Slovenian: Študije so zajele možgansko, sinusno, pljučno in diseminirano aspergilozo pri bolnikih po presaditvi kostnega mozga in presaditvi organov, s hematološkimi malignomi, rakom in aidsom.
English: • Heart rhythm problems including very fast heartbeat, very slow heartbeat, fainting
Slovenian: • težave s srčnim ritmom, vključno s prehitrim utripom in prepočasnim utripom, omedlevica
English: Serious dermatological adverse reactions
Slovenian: Resni dermatološki neželeni učinki
English: Fertility In an animal study, no impairment of fertility was demonstrated in male and female rats (see section 5.3).
Slovenian: Plodnost Študije na živalih niso pokazale zmanjšane plodnosti pri podganjih samcih in samicah (glejte poglavje 5.3).
English: Frequent monitoring for opiateassociated adverse reactions may be necessary (see section 4.5).
Slovenian: Lahko je potreben pogost nadzor glede pojavljanja z opiati povezanih neželenih učinkov (glejte poglavje 4.5).
English: Depending on the severity of symptoms, consideration should be given to stopping treatment (see section 4.8).
Slovenian: Glede na izrazitost simptomov je treba pretehtati možnost prekinitve zdravljenja (glejte poglavje 4.8).
English: • Phototoxicity
Slovenian: • Fototoksičnost
English: Visual impairments may be associated with higher plasma concentrations and/or doses.
Slovenian: okvare vida so lahko povezane z večjimi koncentracijami v plazmi in/ali večjimi odmerki.
English: • Low blood pressure, inflammation of a vein (which may be associated with the formation of a blood clot)
Slovenian: • nizek krvni tlak, vnetje žile (ki je lahko povezano z nastankom krvnega strdka)
English: Elderly No dose adjustment is necessary for elderly patients (see section 5.2).
Slovenian: Starejši Pri starejših bolnikih odmerka ni treba prilagoditi (glejte poglavje 5.2).
English: • Jaundice; changes in blood tests of liver function
Slovenian: • zlatenica; spremembe izvidov krvnih preiskav za spremljanje delovanja jeter
English: Tell your doctor if you are taking any of the following medicines, as a dose adjustment or monitoring may be required to check that the medicines and/or Voriconazole Hikma are still having the desired effect:
Slovenian: Zdravniku povejte, če jemljete katerokoli od naslednjih zdravil, ker bo morda potrebna prilagoditev odmerka ali nadziranje, da preveri, ali imajo le-ta oziroma zdravilo Vorikonazol Hikma še vedno želeni učinek:
English: In a study in healthy volunteers investigating the impact of voriconazole on retinal function, voriconazole caused a decrease in the electroretinogram (ERG) waveform amplitude.
Slovenian: V študiji, s katero so pri zdravih prostovoljcih proučevali vpliv vorikonazola na delovanje mrežnice, je vorikonazol zmanjšal amplitudo valov v elektroretinogramu (ERG).
English: The recommended doses in children and adolescent patients are based on a population pharmacokinetic analysis of data obtained from 112 immunocompromised paediatric patients aged 2 to <12 years and 26 immunocompromised adolescent patients aged 12 to <17 years.
Slovenian: Priporočeni odmerki pri otrocih in mladostnikih temeljijo na podatkih analize populacijske farmakokinetike, zbranih pri 112 imunsko oslabelih pediatričnih bolnikih, starih od 2 do < 12 let, ter 26 imunsko oslabelih mladostnikih, starih od 12 do < 17 let.
English: For patients less than 40 kg the oral dose may be increased to 150 mg twice daily.
Slovenian: Pri bolnikih, ki tehtajo manj kot 40 kg, se peroralni odmerek lahko poveča na 150 mg dvakrat na dan.
English: Median duration of IV voriconazole therapy was 10 days (range 2-85 days).
Slovenian: obliko vorikonazola je bila 10 dni (območje 2-85 dni).
English: • Infusion site reaction
Slovenian: • reakcije na mestu infundiranja
English: Dose reduction of benzodiazepines should be considered.
Slovenian: Razmisliti je treba o zmanjšanju odmerka benzodiazepinov..
English: In addition voriconazole shows in vitro fungicidal activity against emerging fungal pathogens, including those such as Scedosporium or Fusarium which have limited susceptibility to existing antifungal agents.
Slovenian: Poleg tega deluje vorikonazol in vitro fungicidno proti pojavljajočim se glivičnim patogenom, vključno s takšnimi, kot sta Scedosporium ali Fusarium, ki sta le omejeno občutljiva za obstoječa antimikotična zdravila.
English: It is recommended that voriconazole is administered at a maximum rate of 3 mg/kg per hour over 1 to 3 hours.
Slovenian: Vorikonazol je priporočljivo dajati s hitrostjo največ 3 mg/kg na uro v obdobju 1 do 3 ur.
English: A study has been conducted in healthy volunteers which examined the effect on QTc interval of single doses of voriconazole up to 4 times the usual daily dose.
Slovenian: Na zdravih prostovoljcih je bila izvedena študija, ki je preučevala učinek enkratnega odmerka vorikonazola, v višini 4-kratnega običajnega dnevnega odmerka, na interval QTc.
English: Voriconazole is haemodialysed with a clearance of 121 ml/min.
Slovenian: Vorikonazol se hemodializira z očistkom 121 ml/min.
English: A placebo-controlled, randomized, single-dose, crossover study to evaluate the effect on the QTc interval of healthy volunteers was conducted with three oral doses of voriconazole and ketoconazole.
Slovenian: S placebom nadzorovana, randomizirana, navzkrižna študija z enkratnim odmerkom, ki je ocenjevala vpliv na interval QTc, je bila izvedena s tremi peroralnimi odmerki vorikonazola in ketokonazola pri zdravih prostovoljcih.
English: Rare ≥ 1/10,000 to <
Slovenian: Redki ≥ 1/10.000 do
English: 9 mg/kg twice daily (a maximum dose of 350 mg twice daily)
Slovenian: 9 mg/kg dvakrat na dan (največji odmerek 350 mg dvakrat na dan)
English: Each vial contains 200 mg voriconazole, equivalent to 10 mg/ml solution when reconstituted as directed by your hospital pharmacist or nurse.
Slovenian: Ena viala vsebuje 200 mg vorikonazola, kar ustreza raztopini 10 mg/ml, če jo bolnišnični farmacevt ali medicinska sestra pripravita po navodilu.
English: After reconstitution each ml contains 10 mg of voriconazole.
Slovenian: Po rekonstituciji 1 ml vsebuje 10 mg vorikonazola.
English: In case of treatment-related adverse events (hepatotoxicity, severe skin reactions including phototoxicity and SCC, severe or prolonged visual disorders and periostitis), discontinuation of voriconazole and use of alternative antifungal agents must be considered.
Slovenian: V primeru pojava z zdravljenjem povezanih neželenih učinkov (hepatotoksičnost, hude kožne reakcije, vključno s fototoksičnostjo in ploščatoceličnim karcinomom, hude ali dolgotrajne motnje vida ter periostitis), je treba razmisliti o prekinitvi zdravljenja z vorikonazolom in uporabi drugih antimikotikov.
English: • Heart rhythm or conduction problems that (sometimes life threatening)
Slovenian: • hude težave s srčnim ritmom ali prevajanjem (včasih smrtno nevarne)
English: PHARMACEUTICAL FORM Powder for solution for infusion (powder for infusion) White to off-white lyophilised cake.
Slovenian: FARMACEVTSKA OBLIKA prašek za raztopino za infundiranje (prašek za infundiranje) Bela do umazano bela liofilizirana pogača.
English: In vitro, voriconazole displays broad-spectrum antifungal activity with antifungal potency against Candida species (including fluconazole resistant C. krusei and resistant strains of C. glabrata and C. albicans) and fungicidal activity against all Aspergillus species tested.
Slovenian: Vorikonazol ima in vitro širok spekter antimikotičnega delovanja z antimikotičnim učinkom proti vrsti Candida (vključno s C. krusei, odporno na flukonazol, in odpornimi sevi C. glabrata in C. albicans) ter fungiciden učinek proti vsem testiranim vrstam Aspergillus.
English: Chemical and physical in-use stability has been demonstrated for 36 hours at 2°C to 8° C for the reconstituted solution.
Slovenian: Kemična in fizikalna stabilnost rekonstituirane raztopine med uporabo sta bili dokazani za 36 ur pri temperaturi med 2 °C in 8 °C.
English: Each vial contains 217.6 mg of sodium.
Slovenian: Ena viala vsebuje 217,6 mg natrija.
English: Specifically, for C. glabrata, the MICs of voriconazole for fluconazole-resistant isolates are proportionally higher than are those of fluconazole-susceptible isolates.
Slovenian: Še zlasti je značilno, da so pri C. glabrata minimalne inhibitorne koncentracije (MIK) vorikonazola za izolate, odporne na flukonazol, sorazmerno višje od tistih, ki so bile ugotovljene za izolate, občutljive na flukonazol.
English: Voriconazole Hikma must not be infused into the same line or cannula concomitantly with other intravenous products.
Slovenian: Zdravila Vorikonazol Hikma se ne sme infundirati v isto linijo ali kanilo sočasno z drugimi intravenskimi pripravki.
English: There have been reports of squamous cell carcinoma of the skin in patients treated with voriconazole for long periods of time; the mechanism has not been established (see section 4.4).
Slovenian: Pri bolnikih, ki so se dlje časa zdravili z vorikonazolom, so poročali o ploščatoceličnem karcinomu kože; mehanizem ni dokazan (glejte poglavje 4.4).
English: These visual impairmentswere transient and fully reversible, with the majority spontaneously resolving within 60 minutes and no clinically significant long-term visual effects were observed.
Slovenian: Okvare vida so bile prehodne in popolnoma reverzibilne; večina jih je spontano minila v 60 minutah in niso opazili nobenih klinično pomembnih dolgotrajnih učinkov na vid. Obstajali so dokazi o njihovem zmanjševanju s ponavljajočimi odmerki vorikonazola.
English: Dose reduction of NSAIDs may be needed.
Slovenian: Morda bo treba odmerek NSAID zmanjšati.
English: • Warfarin and other anticoagulants (e.g. phenprocoumon, acenocoumarol; used to slow down clotting of the blood)
Slovenian: • varfarin ali druge antikoagulante (npr. fenprokumon, acenokumarol; uporabljajo se za upočasnitev strjevanja krvi)
English: • Hair loss
Slovenian: • izguba las
English: This will be given to you by intravenous infusion (into a vein) at a maximum rate of 3 mg/kg per hour over 1 to 3 hours.
Slovenian: Zdravilo boste dobili v intravenski infuziji (v veno) z največjo hitrostjo 3 mg/kg na uro; infuzija bo tekla od 1 do 3 ure.
English: Liver dysfunction has usually been reversible on discontinuation of therapy (see section 4.8).
Slovenian: Jetrna disfunkcija je bila po prekinitvi zdravljenja običajno reverzibilna (glejte poglavje 4.8).
English: Omeprazole Cmax ↑ 116% Omeprazole AUCτ ↑ 280% Voriconazole Cmax ↑ 15% Voriconazole AUCτ ↑ 41% Other proton pump inhibitors that are CYP2C19 substrates may also be inhibited by voriconazole and may result in increased plasma concentrations of these medicinal products.
Slovenian: omeprazol Cmax ↑ 116% omeprazol AUCτ ↑ 280% vorikonazol Cmax ↑ 15% vorikonazol AUCτ ↑ 41% Vorikonazol lahko zavre tudi presnovo drugih zaviralcev protonske črpalke, ki so substrati CYP2C19, zaradi česar se zviša njihova koncentracija v plazmi.
English: Voriconazole Hikma must not be used during pregnancy, unless indicated by your doctor.
Slovenian: Zdravila Vorikonazol Hikma se med nosečnostjo ne sme jemati, razen če tako ne odloči vaš zdravnik.
English: Although not studied, increased plasma concentrations of these medicinal products can lead to QTc prolongation and rare occurrences of torsades de pointes.
Slovenian: Čeprav ni raziskano, lahko povečana koncentracija teh zdravil v plazmi povzroči podaljšanje QTc in v redkih primerih nastanek torsades de pointes.
English: No subject experienced an interval exceeding the potentially clinically relevant threshold of 500 msec (see section 5.1).
Slovenian: Pri nobenem od preskušancev ni prišlo do podaljšanja intervala prek potencialno klinično pomembnih 500 milisekund (glejte poglavje 5.1).
English: Infusions of blood products must not occur simultaneously with Voriconazole Hikma.
Slovenian: Infuzije krvnih pripravkov se ne sme dajati hkrati z zdravilom Vorikonazol Hikma .
English: In an oral multiple dose study, Cmax and AUCτ for healthy young females were 83 % and 113 % higher, respectively, than in healthy young males (18-45 years).
Slovenian: V študiji večkratnih peroralnih odmerkov je bila pri zdravih mladih ženskah Cmax 83 % višja, AUCτ pa 113 % višja kot pri zdravih mladih moških (18-45 let).
English: - If you have any further questions, ask your doctor,pharmacist or nurse.
Slovenian: - Če imate dodatna vprašanja, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: The efficacy of voriconazole compared to the regimen of amphotericin B followed by fluconazole in the primary treatment of candidaemia was demonstrated in an open, comparative study.
Slovenian: Učinkovitost vorikonazola v primerjavi s shemo amfotericina B, ki mu je sledil flukonazol (shema amfotericin B/flukonazol), je v primarnem zdravljenju kandidemije dokazala odprta primerjalna študija.
English: • Oxycodone and other long acting opiates such as hydrocodone (used for moderate to severe pain)
Slovenian: • oksikodon in druge dolgodelujoče opiate, kot na primer hidrokodon (uporablja se pri zmernih do hudih bolečinah)
English: This includes cases of jaundice, hepatitis and hepatic failure leading to death (see section 4.4).
Slovenian: Mednje spadajo primeri ikterusa, hepatitisa in jetrne odpovedi s posledično smrtjo (glejte poglavje 4.4).
English: Prior to use this medicine does not require any special temperature storage conditions.
Slovenian: Pred uporabo za shranjevanje zdravila ni posebnih temperaturnih omejitev.
English: Voriconazole should be administered with caution to patients with potentially proarrhythmic conditions, such as
Slovenian: Vorikonazol je treba pazljivo predpisati bolnikom s potencialno proaritmičnimi stanji, kot so:
English: It is likely that these subjects may metabolize voriconazole more similarly to children than to adolescents/adults.
Slovenian: Mogoče je, da je presnova vorikonazola pri teh preskušancih bolj podobna presnovi pri otrocih kakor tisti pri mladostnikih/odraslih.