FrancophonIA/ELRC3.0 huggingface dataset:
English: Lopinavir concentrations: similar to lopinavir/ritonavir 400/100 mg twice daily without efavirenz.
Danish: Lopinavirkoncentrationer: samme som for lopinavir/ritonavir 400/100 mg to gange dagligt uden efavirenz.
English: Emtricitabine and tenofovir disoproxil: A large amount of data on pregnant women (more than 1000 pregnancy outcomes) indicates no malformations or foetal/neonatal toxicity associated with emtricitabine and tenofovir disoproxil.
Danish: Emtricitabin og tenofovirdisoproxil: Data fra anvendelse af emtricitabin og tenofovirdisoproxil hos et stort antal gravide kvinder (mere end 1.000) indikerer ingen misdannelser eller føtal/neonatal toksicitet i forbindelse med emtricitabin og tenofovirdisoproxil.
English: - methadone (used to treat opiate addiction)
Danish: Methadon (medicin til behandling af stofmisbrug)
English: Following multiple dose oral administration of emtricitabine to 20 HIV infected patients, steady-state Cmax was 1.8 ± 0.7 µg/ml (mean ± S.D.) (39%CV), steady-state Cmin was 0.09 ± 0.07 µg/ml (80%) and the AUC was 10.0 ± 3.1 µg•h/ml (31%) over a 24 hour dosing interval.
Danish: Efter oral administration af multiple emtricitabindoser til 20 hiv-inficerede patienter var steady-state Cmax 1,8 ± 0,7 µg/ml (middel ± S.D.) (39%CV), steady-state Cmin var 0,09 ± 0,07 µg/ml (80%) og AUC var 10,0 ± 3,1 µg·t/ml (31%) i løbet af et 24-timers doseringsinterval.
English: Atripla has not been studied in patients over the age of 65.
Danish: Atripla er ikke blevet undersøgt hos patienter over 65 år.
English: Experience with efavirenz in patients who discontinued other antiretroviral agents of the NNRTI class is limited.
Danish: Der er begrænset erfaring med efavirenz hos patienter, som er ophørt med andre antiretrovirale lægemidler af NNRTI-gruppen.
English: Animal studies do not indicate harmful effects of efavirenz, emtricitabine or tenofovir disoproxil on fertility.
Danish: Dyreforsøg indikerer ingen skadelige virkninger af efavirenz, emtricitabin eller tenofovirdisoproxil på fertiliteten.
English: Desacetyl diltiazem: AUC: ↓ 75% (↓ 59 to ↓ 84)
Danish: Desacetyl diltiazem: AUC: ↓ 75% (↓ 59 til ↓ 84)
English: As Atripla contains efavirenz, emtricitabine and tenofovir disoproxil, any interactions that have been identified with these agents individually may occur with Atripla.
Danish: Da Atripla indeholder efavirenz, emtricitabin og tenofovirdisoproxil, kan interaktioner, som er identificeret med disse lægemidler individuelt, opstå med Atripla.
English: Atripla is not recommended in this population (see section 4.2).
Danish: Atripla bør ikke anvendes til denne population (se pkt.
English: There were no clinically significant pharmacokinetic interactions when efavirenz was administered with azithromycin, cetirizine, fosamprenavir/ritonavir, lorazepam, nelfinavir, zidovudine, aluminium/magnesium hydroxide antacids, famotidine or fluconazole.
Danish: Der var ingen klinisk signifikante farmakokinetiske interaktioner, når efavirenz blev administreret sammen med azithromycin, cetirizin, fosamprenavir/ritonavir, lorazepam, nelfinavir, zidovudin, aluminium/magnesiumhydroxidantacida, famotidin eller fluconazol.
English: Some examples include, but are not limited to, aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2 (see section 4.4).
Danish: Eksempler omfatter, men er ikke begrænset til, aminoglykosider, amphotericin B, foscarnet, ganciclovir, pentamidin, vancomycin, cidofovir eller interleukin-2 (se pkt.
English: Hydroxyitraconazole:
Danish: Hydroxyitraconazol:
English: The pharmacokinetics of emtricitabine have not been studied in non-HBV infected patients with varying degrees of hepatic insufficiency.
Danish: Emtricitabins farmakokinetik er ikke undersøgt hos ikke-HBV-inficerede patienter med varierende grader af leverinsufficiens.
English: If concomitant use of Atripla and nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir, interleukin-2) is unavoidable, renal function must be monitored weekly (see section 4.5).
Danish: Hvis samtidig brug af Atripla og nefrotoksiske lægemidler (f.eks. aminoglykosider, amphotericin B, foscarnet, ganciclovir, pentamidin, vancomycin, cidofovir, interleukin-2) er uundgåelig, skal nyrefunktionen monitoreres ugentligt (se pkt.
English: When Atripla is taken with rifampicin in patients weighing 50 kg or greater, an additional 200 mg/day (800 mg total) of efavirenz may provide exposure similar to a daily efavirenz dose of 600 mg when taken without rifampicin.
Danish: Når Atripla tages sammen med rifampicin hos patienter, der vejer 50 kg eller derover, kan yderligere 200 mg/dag (800 mg i alt) efavirenz give samme eksponering som en daglig efavirenzdosis på 600 mg, når det tages uden rifampicin.
English: The pharmacokinetics, safety and efficacy of Atripla have not been established in patients with significant underlying liver disorders (see section 5.2).
Danish: Atriplas farmakokinetik, sikkerhed og virkning er ikke klarlagt hos patienter med signifikante, tilgrundliggende leversygdomme (se pkt.
English: If your doctor decides to stop one of the components of Atripla, you may be given efavirenz, emtricitabine and/or tenofovir disoproxil separately or with other medicines for the treatment of your HIV infection.
Danish: Hvis Deres læge beslutter at stoppe behandlingen med et af de aktive stoffer i Atripla, kan De få efavirenz, emtricitabin og/eller tenofovirdisoproxil hver for sig eller sammen med anden medicin til behandling af Deres hiv-infektion.
English: Atripla 600 mg/200 mg/245 mg film-coated tablets Efavirenz/emtricitabine/tenofovir disoproxil
Danish: Atripla 600 mg/200 mg/245 mg filmovertrukne tabletter Efavirenz/emtricitabin/tenofovirdisoproxil
English: Psychiatric disorders: Common depression (severe in 1.6%)3, anxiety3, abnormal dreams3, insomnia3
Danish: Depression (svær hos 1,6%)3, angst3, abnorme drømme3, søvnløshed3
English: Compared to fasted administration, dosing of tenofovir disoproxil and emtricitabine in combination with either a high fat meal or a light meal increased the mean AUC of tenofovir by 43.6% and 40.5%, and Cmax by 16% and 13.5%, respectively without affecting emtricitabine exposures.
Danish: Sammenlignet med administration under faste blev tenofovirs gennemsnitlige AUC forhøjet med henholdsvis 43,6% og 40,5% og Cmax med 16% og 13,5% ved dosering af tenofovirdisoproxil og emtricitabin i kombination med enten et fedtrigt eller et let måltid uden at påvirke emtricitabin-eksponeringen.
English: Carbamazepine can reduce the amount of efavirenz, one of the components of Atripla, in your blood.
Danish: Carbamazepin kan nedsætte mængden af efavirenz, der er et af de aktive stoffer i Atripla, i blodet.
English: Headache has been reported in clinical studies with emtricitabine (see section 4.8).
Danish: Hovedpine er indberettet i kliniske studier med emtricitabin (se pkt.
English: Buprenorphine/naloxone/Emtricitabine Interaction not studied.
Danish: Buprenorphin/naloxon/emtricitabin Interaktion er ikke undersøgt.
English: • yellow skin or eyes, itching, or pain in the abdomen (stomach) caused by inflammation of the liver
Danish: • Gulfarvning af hud eller øjne, kløe eller mavesmerter fremkaldt af betændelse i leveren
English: Atripla was administered on an empty stomach (see section 4.2).
Danish: Atripla blev administreret på tom mave (se pkt.
English: If a patient misses a dose of Atripla within 12 hours of the time it is usually taken, the patient should take Atripla as soon as possible and resume the normal dosing schedule.
Danish: Hvis en patient glemmer at tage en dosis Atripla i mindre end 12 timer efter tidspunktet, hvor patienten normalt tager dosen, skal patienten tage Atripla så snart som muligt og derefter fortsætte med den normale doseringsplan.
English: In vivo resistance (antiretroviral-naïve patients): In a 144-week open-label randomised clinical study (GS-01-934) in antiretroviral-naïve patients, where efavirenz, emtricitabine and tenofovir disoproxil were used as individual formulations (or as efavirenz and the fixed combination of emtricitabine and tenofovir disoproxil (Truvada) from week 96 to 144), genotyping was performed on plasma HIV-1 isolates from all patients with confirmed HIV RNA > 400 copies/ml at week 144 or early study drug discontinuation (see section on Clinical experience).
Danish: In vivo-resistens (antiretroviral-naive patienter): I et 144-ugers åbent, randomiseret, klinisk studie (GS-01-934) med antiretroviral-naive patienter, hvor efavirenz, emtricitabin og tenofovirdisoproxil blev anvendt som individuel formulering (eller som efavirenz og en fast kombination af emtricitabin og tenofovirdisoproxil (Truvada) fra uge 96 til 144), er der foretaget genotypebestemmelser på plasma-hiv-1-isolater fra alle patienter med bekræftet hiv-rna > 400 kopier/ml i uge 144 eller tidlig seponering (se afsnittet om Klinisk erfaring).
English: Your doctor may do blood tests to see if your kidneys are working properly
Danish: Deres læge vil måske tage blodprøver for at se, om nyrerne fungerer ordentligt.
English: Inflammation of the pancreas and lactic acidosis (excess lactic acid in the blood), which sometimes caused death, have been reported rarely when medicines containing tenofovir disoproxil and didanosine were taken together.
Danish: Der er set sjældne tilfælde af betændelse i bugspytkirtlen og laktatacidose (overskud af mælkesyre i blodet), der nogle gange har medført dødsfald, når medicin, der indeholder tenofovirdisoproxil blev indtaget samtidigt med didanosin.
English: - If you get any side effects, talk to your doctor or pharmacist.
Danish: Hvis De oplever bivirkninger, bør De tale med Deres læge eller apoteket.
English: 4 This adverse reaction was identified through post-marketing surveillance for either efavirenz, emtricitabine or tenofovir disoproxil.
Danish: 4 Denne bivirkning blev identificeret under sikkerhedsovervågningen efter markedsføring for enten efavirenz, emtricitabin eller tenofovirdisoproxil.
English: It is important to tell your doctor or pharmacist if you are taking any of the following: - Medicines containing didanosine (for HIV infection): Taking Atripla with other antiviral medicines that contain didanosine can raise the levels of didanosine in your blood and may reduce CD4 cell counts.
Danish: - Medicin der indeholder didanosin (mod hiv-infektion): Hvis De tager Atripla sammen med andre antivirale lægemidler, som indeholder didanosin, kan det øge indholdet af didanosin i blodet og nedsætte CD4-celletallet.
English: A third subject had pre-existing NNRTI resistance-associated substitutions to efavirenz and the M184V reverse transcriptase resistance-associated substitution to emtricitabine at entry into the Atripla extension phase and experienced a suboptimal virologic response, and developed K65K/R, S68N and K70K/E NRTI resistance-associated substitutions at week 180 (36 weeks on Atripla).
Danish: En tredje patient havde præeksisterende NNRTI-resistens-associerede substitutioner over for efavirenz og M184V-revers transkriptase-substitutionen associeret med resistens over for emtricitabin ved inklusionen i den forlængede fase med Atripla og oplevede et suboptimalt virologisk respons og udviklede K65K/R-, S68N- og K70K/E-substitutioner associeret med resistens over for NRTI ved uge 180 (36 uger på Atripla).
English: Decreased exposure of etonogestrel may be expected (CYP3A4 induction).
Danish: Reduceret eksponering for etonogestrel kan forventes (CYP3A4induktion).
English: Women of childbearing potential should undergo pregnancy testing before initiation of Atripla.
Danish: Kvinder i den fertile alder bør altid få foretaget graviditetstest før initiering af behandling med Atripla.
English: Co-administration of tenofovir disoproxil and didanosine results in a 40-60% increase in systemic exposure to didanosine that may increase the risk for didanosine-related adverse reactions.
Danish: Samtidig administration af tenofovirdisoproxil og didanosin medførte en stigning på 40-60% i systemisk eksponering for didanosin, som kan øge risikoen for didanosin-relaterede bivirkninger.
English: Atovaquone:
Danish: Atovaquon:
English: General disorders and administration site conditions: Very common asthenia
Danish: Almene symptomer og reaktioner på administrationsstedet: Meget almindelig
English: Efavirenz+lamivudine/zid ovudine (N=243)
Danish: Efavirenz+ lamivudin/zidovudin (N=243)
English: If you do miss a dose of Atripla within 12 hours of when it is usually taken, take it as soon as you can, and then take your next dose at its regular time.
Danish: Hvis De - inden for 12 timer efter, dosis normalt tages - kommer i tanker om, at De har glemt at tage en dosis, skal De tage den så hurtigt som muligt og derefter tage den næste dosis på det normale tidspunkt.
English: Concomitant administration of simeprevir with efavirenz, a component of Atripla, resulted in significantly decreased plasma concentrations of simeprevir due to CYP3A induction by efavirenz, which may result in loss of therapeutic effect of simeprevir.
Danish: Samtidig administration af simeprevir og efavirenz, et aktivt stof i Atripla, resulterede i signifikant nedsat simeprevirplasmakoncentration på grund af efavirenzforårsaget CYP3A-induktion, som kan resultere i manglende terapeutisk virkning af simeprevir.
English: Severe skin reactions such as Stevens-Johnson syndrome and erythema multiforme; neuropsychiatric adverse reactions (including severe depression, death by suicide, psychosis-like behaviour, seizures); severe hepatic events; pancreatitis and lactic acidosis (sometimes fatal) have been reported.
Danish: Svære hudreaktioner, såsom Stevens-Johnsons syndrom og erythema multiforme, neuropsykiatriske bivirkninger (herunder svær depression, selvmord, psykose-lignende opførsel, kramper), svær leverpåvirkning, pancreatitis og laktatacidose er rapporteret (og nogle af disse tilfælde var letale).
English: If you notice any of these symptoms please inform your doctor.
Danish: Hvis De bemærker et eller flere af disse symptomer, skal De informere Deres læge.
English: If you could get pregnant while receiving Atripla, you need to use a reliable form of barrier contraception (for example, a condom) with other methods of contraception including oral (pill) or other hormonal contraceptives (for example, implants, injection).
Danish: Hvis De kan blive gravid, er det nødvendigt, at De bruger en pålidelig form for barriereprævention (f.eks. kondom) sammen med andre former for prævention, herunder P-piller eller andre hormonale præventionsmidler (f.eks. implantat, injektion), mens De tager Atripla.
English: ↓ exposure of the immunosuppressant may be expected (CYP3A4 induction).
Danish: ↓ eksponering af det immunsupprimerende lægemiddel kan forventes (CYP3A4-induktion).
English: When efavirenz is co-administered with a calcium channel blocker that is a substrate of the CYP3A4 enzyme, there is a potential for reduction in the plasma concentrations of the calcium channel blocker.
Danish: Når efavirenz administreres samtidigt med en calciumantagonist, som er et substrat for CYP3A4-enzymet, er reduktion af calciumantagonistens plasmakoncentrationer mulig.
English: In the prior-NNRTI stratum, response rates were 98.9% vs 97.4% for Atripla and SBR patients respectively; a difference (95%CI) of 1.4% (-4.0%, 6.9%)].
Danish: I før-NNRTI-stratummet var responsraten 98,9% versus 97,4% for henholdsvis Atripla- og SBR-patienterne; en forskel (95% CI) på 1,4% (-4,0%; 6,9%).
English: Specific interaction studies have not been performed with efavirenz and NRTIs other than lamivudine, zidovudine and tenofovir disoproxil.
Danish: Der er ikke udført specifikke interaktionsstudier med efavirenz og NRTIer bortset fra lamivudin, zidovudin og tenofovirdisoproxil.
English: Following oral administration of a single 300 mg dose of tenofovir disoproxil to HIV-1 infected patients in the fasted state, maximum tenofovir concentrations were achieved within one hour and the Cmax and AUC (mean ± S.D.) (%CV) values were 296 ± 90 ng/ml (30%) and 2,287 ± 685 ng•h/ml (30%), respectively.
Danish: Efter oral administration af en enkelt dosis tenofovirdisoproxil 300 mg til hiv-1-inficerede patienter i faste opnåedes maksimal tenofovirkoncentration inden for en time og Cmax og AUC (middel ± S.D.) (%CV) værdierne var henholdsvis 296 ± 90 ng/ml (30%) og 2.287 ± 685 ng·t/ml (30%).
English: • The M184V/I mutation developed in 2/19 (10.5%) isolates analysed from patients in the efavirenz + emtricitabine + tenofovir disoproxil group and in 10/29 (34.5%) isolates analysed from the efavirenz + lamivudine/zidovudine group (p-value < 0.05, Fisher's Exact test comparing the emtricitabine + tenofovir disoproxil group to the lamivudine/zidovudine group among all subjects).
Danish: • M184V/I-mutationen udviklede sig hos 2/19 (10,5%) af de isolater, der blev analyseret fra patienter i efavirenz + emtricitabin + tenofovirdisoproxil-gruppen og hos 10/29 (34,5%) af de isolater, der blev analyseret fra efavirenz + lamivudin/zidovudin-gruppen (p-værdi < 0,05; Fishers eksakte test, som sammenligner alle patienterne fra henholdsvis emtricitabin + tenofovirdisoproxil-gruppen med lamivudin/zidovudin-gruppen).
English: A decreased dosage of 250 mg didanosine co-administered with tenofovir disoproxil therapy has been associated with reports of high rates of virologic failure within several tested combinations.
Danish: I forbindelse med en reduceret dosis på 250 mg didanosin administreret samtidig med tenofovirdisoproxil er der blevet rapporteret om en høj forekomst af manglende virologisk virkning af flere testede kombinationer.
English: It is indicated for the treatment of human immunodeficiency virus-1 (HIV-1) infection in adults aged 18 years and over with virologic suppression to HIV-1 RNA levels of < 50 copies/ml on their current combination antiretroviral therapy for more than three months.
Danish: Atripla er indiceret til behandling af human immundefekt virus-1 (hiv-1)-infektion hos voksne i alderen 18 år og derover med virologisk suppression til hiv-1-rna-koncentrationer < 50 kopier/ml, som er i antiretroviral kombinationsbehandling og har været det i mere end 3 måneder.
English: The K65R mutation can also be selected by abacavir or didanosine and results in reduced susceptibility to these agents plus lamivudine, emtricitabine and tenofovir.
Danish: K65R-mutationen kan desuden selekteres ved hjælp af abacavir eller didanosin og forårsager nedsat følsomhed over for disse stoffer samt lamivudin, emtricitabin og tenofovir.
English: The following pack sizes are available: outer cartons containing 1 bottle of 30 film-coated tablets and 90 (3 bottles of 30) film-coated tablets.
Danish: Fås i pakninger, der indeholder 1 beholder med 30 filmovertrukne tabletter og 90 (3 beholdere med 30) filmovertrukne tabletter.
English: Your doctor may consider giving you an alternative medicine or changing the dose of the protease inhibitors.
Danish: Deres læge kan overveje at give Dem anden medicin eller ændre dosis af proteasehæmmerne.
English: (decrease in itraconazole concentrations: CYP3A4 induction)
Danish: (fald i itraconazolkoncentrationerne: CYP3A4-induktion)
English: They include some common medicines and some herbal preparations (including St. John's wort) which can cause serious interactions.
Danish: Det omfatter nogle almindelige lægemidler og nogle naturlægemidler (inklusive perikon), som kan forårsage alvorlige bivirkninger.
English: Your doctor may need to consider changing your dose or giving you an alternative antibiotic.
Danish: Deres læge kan finde det nødvendigt at ændre Deres dosis eller give Dem et andet antibiotikum.
English: Sufficient data on the tolerability of efavirenz with low-dose ritonavir (100 mg, once or twice daily) are not available.
Danish: tolerancen over for efavirenz sammen med lav-dosis ritonavir (100 mg, én eller to gange dagligt).
English: In 35 patients receiving efavirenz 600 mg once daily, steady-state peak concentration (Cmax) was 12.9 ± 3.7 µM (29%) [mean ± standard deviation (S.D.) (coefficient of variation (%CV))], steady-state Cmin was 5.6 ± 3.2 µM (57%), and AUC was 184 ± 73 µM•h (40%).
Danish: Hos 35 patienter, der fik 600 mg efavirenz en gang dagligt, var den højeste steady-state-koncentration (Cmax) 12,9 ± 3,7 µM (29%) [middel ± standarddeviation (S.D.) (variationskoefficient (%CV))], steady-state Cmin var 5,6 ± 3,2 µM (57%) og AUC var 184 ± 73 µM·t (40%).
English: If you notice any symptoms of infection, please tell your doctor at once.
Danish: Hvis De bemærker symptomer på infektion, skal De omgående fortælle Deres læge det.
English: Artemether/Lumefantrine/Emtricitabine Interaction not studied.
Danish: Artemether/lumefantrin/emtricitabin Interaktion er ikke undersøgt.
English: The rash associated with the efavirenz component usually resolves with continued therapy.
Danish: Udslæt associeret med efavirenz forsvinder sædvanligvis ved fortsat behandling.
English: Prior NNRTI-based regimen (N=104)
Danish: Tidligere NNRTI-baseret behandling (N=104)
English: Because of the limited information available, a reliable method of barrier contraception must be used in addition to hormonal contraceptives (see section 4.6).
Danish: Grundet den begrænsede tilgængelige information, skal en pålidelig kontraceptiv barrieremetode anvendes sammen med hormonkontraceptiva (se pkt.
English: N-monodesmethyl diltiazem: AUC: ↓ 37% (↓ 17 to ↓ 52)
Danish: N-monodesmethyldiltiazem: AUC: ↓ 37% (↓ 17 til ↓ 52)
English: - if you have a history of convulsions (fits or seizures) or if you are being treated with anticonvulsant therapy such as carbamazepine, phenobarbital and phenytoin.
Danish: Hvis De tidligere har haft kramper (krampeanfald), eller hvis De får krampestillende behandling med f.eks. carbamazepin, phenobarbital og phenytoin.
English: QT Prolonging Drugs: Atripla is contraindicated with concomitant use of drugs that are known to prolong the QTc interval and could lead to Torsade de Pointes, such as: antiarrhythmics of classes IA and III, neuroleptics and antidepressant agents, certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones, imidazole, and triazole antifungal agents, certain non-sedating antihistaminics (terfenadine, astemizole), cisapride, flecainide, certain antimalarials and methadone (see section 4.3).
Danish: QT-forlængende lægemidler: Atripla er kontraindiceret ved samtidig brug af lægemidler, som vides at forlænge QTc-intervallet og kan føre til Torsade de Pointes, f.eks. antiarytmika af klasse IA og III, neuroleptika og antidepressiva, visse antibiotika, herunder nogle stoffer af følgende klasser: makrolider, fluorokinoloner, imidazol- og triazol-antimykotika, visse non-sederende antihistaminer (terfenadin, astemizol), cisaprid, flecainid, visse antimalariamidler og methadon (sepkt.
English: • problems with digestion resulting in discomfort after meals, feeling bloated, wind (flatulence)
Danish: • Fordøjelsesproblemer som medfører ubehag efter måltider, oppustethed, øget luftafgang fra tarmen
English: In repeated-dose toxicity studies, biliary hyperplasia was observed in cynomolgus monkeys given efavirenz for ≥ 1 year at a dose resulting in mean AUC values approximately 2-fold greater than those in humans given the recommended dose.
Danish: I toksicitetsstudier efter gentagne doser blev der set biliær hyperplasi i cynomolgusaber, der fik efavirenz i ≥ 1 år i doser, som gav middel AUC-værdier ca. 2 gange højere end hos mennesker, der fik den anbefalede dosis.
English: (decrease in carbamazepine concentrations: CYP3A4 induction; decrease in efavirenz concentrations: CYP3A4 and CYP2B6 induction)
Danish: (fald i carbamazepinkoncen-trationer: CYP3A4-induktion; fald i efavirenzkoncentrationer: CYP3A4CYP2B6-induktion)
English: 1.2% (-2.3% to 6.7%)
Danish: 1,2% (-2,3% til 6,7%)
English: Dose adjustment of warfarin or acenocoumarol may be required when co-administered with Atripla.
Danish: Justering af warfarin- eller acenocoumaroldosis kan være påkrævet, når det administreres samtidigt med Atripla.