FrancophonIA/ELRC3.0 huggingface dataset:
English: Your doctor will advise on an appropriate diet, and may prescribe potassium, calcium or vitamin D supplements.
Croatian: Vaš liječnik će Vam savjetovati odgovarajuću prehranu, te može propisati nadomjeske kalija, kalcija ili vitamina D.
English: However, both incidence and severity of peripheral neuropathy increase with concomitant bortezomib or thalidomide administration.
Croatian: Međutim, i incidencija i ozbiljnost periferne neuropatije povećavaju se s istodobnom primjenom bortezomiba ili talidomida.
English: Acute toxicity of dexamethasone is weak and toxic effects have rarely been observed after an acute overdose.
Croatian: Akutna toksičnost deksametazona je slaba, a toksičan učinak rijetko je uočen nakon akutnog predoziranja.
English: The major part is hydrogenated or hydroxylated in humans, the major metabolites being hydroxy-6-dexamethasone and dihydro-20-dexamethasone.
Croatian: Veći dio je hidrogeniziran ili hidroksiliran u ljudi, pri čemu su glavni metaboliti hidroksi-6-deksametazon i dihidro-20-deksametazon.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim problemima netolerancije na galaktozu, deficijencije Lapp laktaze ili malapsorbcije glukoze-galaktoze ne smiju uzimati ovaj lijek.
English: These are common (may affect up to 1 in 10 people) and may include: - feeling depressed (including thinking about suicide) - feeling high (mania), very happy (euphoria) or moods that go up and down, - feeling anxious, having difficulty in concentrating and memory loss, - feeling, seeing or hearing things that do not exist or believing in things that are not real, having gloomy thoughts, changing how you act.
Croatian: Ove su nuspojave česte (javljaju se u do 1 na 10 osoba) i mogu uključivati: - osjećaj depresije (uključujući i razmišljanja o samoubojstvu) - osjećaj ushićenosti (manija), izrazite sreće (euforija) ili raspoloženja koja se naglo mijenjaju, - osjećaj anksioznosti, poteškoće pri koncentriranju i gubitak pamćenja, - osjećati, vidjeti ili čuti stvari koje ne postoje ili vjerovati u stvari koje nisu stvarne, imati tmurne misli, promjene u ponašanju.
English: The following combinations require precautions due to safety concerns:
Croatian: Sljedeće kombinacije zahtijevaju mjere opreza zbog sigurnosnih razloga:
English: FN was reported to be serious in 4.0% of patients.
Croatian: U 4,0 % bolesnika zabilježena je ozbiljna FN.
English: The administration of such medicinal products and Neofordex should be separated by at least two hours.
Croatian: Takve lijekove i Neofordex treba primjenjivati s razmakom od najmanje dva sata.
English: Do not use this medicine if you notice any defects, or any signs of deterioration of the tablets or packaging.
Croatian: Ovaj lijek se ne smije upotrijebiti ako primijetite oštećenja ili bilo kakve znakove odstupanja u kakvoći tableta ili pakiranja.
English: If affected, patients should be instructed not to drive, use machines or perform hazardous tasks while being treated with dexamethasone.
Croatian: Ako su zahvaćeni, bolesnicima se treba savjetovati da ne upravljaju vozilima, ne koriste strojeve ili ne provode opasne zadatke tijekom liječenja deksametazonom.
English: Laboratoires CTRS 63, rue de l'Est 92100 Boulogne-Billancourt France
Croatian: Laboratoires CTRS 63, rue de l'Est 92100 Boulogne-Billancourt Francuska
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Neofordex therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je donijeti odluku o prekidu dojenja ili prekidu/apstinenciji terapije lijekom Neofordex, pri čemu se mora uzeti u obzir korist od dojenja za dijete i korist od terapije za ženu.
English: • With acetylsalicylic acid, at doses ≥ 1 g per dose or 3 g per day, due to an increased risk of bleeding.
Croatian: • s acetilsalicilatnom kiselinom, pri dozama ≥ 1 g po dozi ili 3 g na dan, zbog povećanog rizika od krvarenja.
English: Depending on the duration of treatment, calcium metabolism may be impaired.
Croatian: Ovisno o trajanju liječenja može doći do oštećenja metabolizma kalcija.
English: If your dose is half a tablet (20 mg), the tablet should be divided into two equal halves.
Croatian: Ako Vam je propisana doza od pola tablete (20 mg), tableta se treba podijeliti na dvije jednake polovice.
English: Prescribing physicians should carefully evaluate which dose of dexamethasone to use, taking into account the condition and disease status of the patient.
Croatian: Propisivači trebaju pažljivo ocijeniti koja će se doza deksametazona primjenjivati uzimajući u obzir uvjete i status bolesti bolesnika.
English: The tablet can be divided for administration of a 20 mg dose (see section 4.2).
Croatian: Tableta se može razdijeliti za primjenu doze od 20 mg (vidjeti dio 4.2).
English: In patients not already prescribed bisphosphonates for multiple myeloma related bone disease, bisphosphonates should be considered, particularly if risk factors for osteoporosis are present.
Croatian: U bolesnika za koje još nisu propisani bisfosfonati za liječene koštanih bolesti povezanih s multiplom mjelomom, treba razmotriti primjenu bisfosfonata, posebno ako su prisutni faktori rizika od osteoporoze.
English: Bioavailability of dexamethasone is approximately 80%.
Croatian: Bioraspoloživost deksametazona je otprilike 80%.
English: Prophylactic antithrombotic treatment should be recommended, especially in patients with additional thrombotic risk factors.
Croatian: Treba preporučiti profilaktično antitrombotsko liječenje, posebice u bolesnika s dodatnim faktorima rizika od tromboze.
English: Treatment must be initiated and monitored under the supervision of physicians experienced in the management of multiple myeloma.
Croatian: Liječenje se treba započeti i provoditi pod nadzorom liječnika s iskustvom u liječenju multiplog mijeloma.
English: • With live attenuated vaccines, due to risk of vaccine-related illness with risk of death.
Croatian: • s živim atenuiranim cjepivima, zbog rizika od s cjepivom povezanom bolesti s rizikom od smrti.
English: At doses ≥ 500 mg per dose or < 3 g per day, precautions are required due to increased risk of haemorrhage, ulcerations and gastro-intestinal perforation.
Croatian: Pri dozama ≥ 500 mg po dozi ili < 3 g na dan potrebno je poduzeti mjere opreza zbog povećanog rizika od krvarenja, ulceracija i gastrointestinalne perforacije.
English: Lactose intolerance
Croatian: Netolerancija na laktozu
English: The decision to take antithrombotic prophylactic measures should be made after careful assessment of an individual patient's underlying risk factors.
Croatian: Odluka o poduzimanju antitrombotskih profilaktičkih mjera treba biti pažljivo donijeta nakon detaljne ocjene prikrivenih faktora rizika bolesnika.
English: You should also tell your doctor if you have recently received a vaccination or are planning to be vaccinated.
Croatian: Svog liječnika morate obavijestiti i o tome jeste li nedavno primili cjepivo ili se planirate cijepiti.
English: Patients/carers should be encouraged to seek medical advice if worrying psychological symptoms develop, especially if depressed mood or suicidal ideation is suspected.
Croatian: Potrebno je potaknuti bolesnike/skrbnike da potraže savjet liječnika ako dođe do razvoja zabrinjavajućih psiholoških simptoma, posebice ako se sumnja na depresivno raspoloženje ili suicidalna razmišljanja.
English: Patients should be monitored clinically, including by endoscopy.
Croatian: Bolesnike treba pratiti klinički, uključujući i endoskopijom.
English: Patients should be made aware of this risk and self-monitoring of blood and urine should be reinforced, especially during the initiation of treatment.
Croatian: Bolesnici moraju biti svjesni ovog rizika te se samostalno praćenje vrijednosti krvi i razina mora intenzivirati, posebice tijekom početka liječenja.
English: No interaction study has been performed with oral contraceptives.
Croatian: Ispitivanja interakcija s oralnim kontkontraceptivima nisu provedena.
English: If you get an infection of any kind during treatment with this medicine, contact your doctor immediately.
Croatian: Ako dobijete bilo kakvu infekciju tijekom liječenja ovim lijekom, odmah kontaktirajte svojeg liječnika.
English: What Neofordex is and what it is used for
Croatian: Što je Neofordex i za što se koristi
English: Dexamethasone crosses the blood-brain barrier and the placental barrier and passes into breast milk.
Croatian: Deksametazon prolazi kroz krvno-moždanu barijeru i placentalnu barijeru i ulazi u mlijeko iz dojki.
English: However, the immune response and hence the effect of the vaccination can be diminished by high glucocorticoid doses.
Croatian: No, imunosni odgovor te stoga i učinak cjepiva mogu biti umanjeni snažnim dozama glukokortikoida.
English: Dexamethasone is a type of hormone called a glucocorticoid, sometimes called a corticoid or corticosteroid, with various actions including effects on white blood cells, which form part of the immune system (the body's natural defences).
Croatian: Deksametazon je vrsta hormona naziva glukokortikoid, koji se ponekad naziva kortikoid ili kortikosteroid, s različitim djelovanjima uključujući učinke na bijele krvne stanice, koje su dio imunološkog sustava (prirodne obrane u tijelu).
English: Elimination The plasma half-life of dexamethasone is approximately 250 minutes.
Croatian: Eliminacija Poluvijek deksametazona u plazmi iznosi otprilike 250 minuta.
English: Pharmacotherapeutic group: Corticosteroids for systemic use, glucocorticoids, ATC code: H02AB02
Croatian: Farmakoterapijska skupina: kortikosteroidi za sistemsku primjenu, glukokortikoidi, ATK oznaka: H02AB02
English: Please inform any doctor, dentist or person who may prescribe a treatment for you that you are currently taking or have recently taken dexamethasone.
Croatian: Molimo obavijestite svakog liječnika, stomatologa ili osobu koja Vam može propisati liječenje da trenutno uzimate ili da ste uzimali deksametazon.
English: This can sometimes lead to infections caused by germs that rarely cause infection under normal circumstances (called opportunistic infections).
Croatian: To ponekad može prouzročiti infekcije koje izazivaju klice koje u normalnim okolnostima rijetko uzrokuju infekciju (naziva oportunističke infekcije).
English: Advise patients to not dispose of unused tablets through household waste or wastewater.
Croatian: Savjetujte bolesnike da ne bacaju neiskorištene tablete u kućni otpad ili otpadne vode.
English: The efficacy and safety of dexamethasone combination treatment in multiple myeloma has been confirmed in numerous clinical studies in newly diagnosed patients and in patients with relapsed or refractory disease.
Croatian: Djelotvornost i sigurnost kombiniranog liječenja deksametazonom za multipli mijelom potvrđeni su u brojnim kliničkim ispitivanjima u novodijagnosticiranih bolesnika i u bolesnika s recidivirajućom ili refraktornom bolesti.
English: Not known: Convulsions.
Croatian: Nepoznato: konvulzije.
English: Dexamethasone is similar to glucocorticoids which are naturally produced in the body.
Croatian: Deksametazon je sličan glukokortikoidima koje tijelo prirodno proizvodi.
English: Neofordex should not be used during pregnancy unless the clinical condition of the woman requires treatment with dexamethasone.
Croatian: Neofordex se ne smije koristiti tijekom trudnoće osim ako kliničko stanje žene ne zahtjeva liječenje deksametazonom.
English: In controlled studies, combination treatment with dexamethasone consistently showed better outcomes in terms of survival and response than single-agent dexamethasone.
Croatian: U kontroliranim ispitivanjima, kombinirano liječenje deksametazonom konstantno je pokazivalo bolje ishode u smislu preživljenja i odgovora od deksametazona kao samostalnog agensa.
English: The patient populations studied included a wide range of ages, as well as patients considered eligible or ineligible for autologous stem cell transplantation.
Croatian: Populacija bolesnika koja je sudjelovala u ispitivanju uključivala je širok dobni raspon, kao i bolesnike smatrane pogodnima ili nepogodnima za autolognu transplantaciju matičnih stanica.
English: If you think you may have had contact with anyone with these conditions, you should inform your doctor immediately.
Croatian: Ako smatrate da ste možda bili u kontaktu s takvom osobom, morate odmah obavijestiti svog liječnika.
English: Patients and physicians are advised to be observant for signs and symptoms of bleeding, including petechiae and epistaxes, especially in case of concomitant treatment susceptible to induce bleeding.
Croatian: Bolesnicima i liječnicima se savjetuje da budu na oprezu zbog znakova i simptoma krvarenja, uključujući petehije i epitakse, posebice u slučaju istodobne primjene liječenja za koju se sumnja da uzrokuje krvarenje.
English: White, oblong (11 mm × 5.5 mm) tablet with a score-line on one face.
Croatian: Bijela, duguljasta (11 mm × 5,5 mm) tableta s razdjelnim urezom na jednoj strani.
English: − Inability of the body to respond normally to severe stress such as accidents, surgery or illness due to insufficient function of the adrenal glands, severe unusual headache with visual disturbances linked to the withdrawal of treatment, irregularity of menstrual cycles in women;
Croatian: Nemogućnost tijela da normalno odgovori na teški oblik stresa poput nesreće, kirurškog zahvata ili bolesti zbog nedovoljne funkcije nadbubrežne žlijezde, ozbiljne neuobičajene glavobolje s poremećajima vida povezanima s ustezanjem od liječenja, nepravilnosti menstrualnog ciklusa u žena;
English: In particular, the requirements of the pregnancy prevention programme for combination treatment with thalidomide or its analogues must be followed.
Croatian: Posebice, moraju se pridržavati zahtjeva programa za prevenciju trudnoće za kombinirano liječenje talidomidom ili njegovim analozima.
English: Patients with hepatic impairment or renal insufficiency require appropriate monitoring; patients with hepatic impairment should be dosed with caution as there are no data for this patient population (see sections 4.4 and
Croatian: Bolesnici s oštećenjem funkcije jetre ili bubrežnom insuficijencijom zahtijevaju odgovarajuće praćenje; doza za bolesnike s oštećenjem funkcije jetre treba se pažljivo odrediti jer ne postoje podaci za ovu populaciju bolesnika (vidjeti dijelove 4.4 i 5.2).
English: Dexamethasone may cause confusional state, hallucinations, dizziness, somnolence, fatigue, syncope and blurred vision (see section 4.8).
Croatian: Deksametazon može uzrokovati konfuzna stanja, halucinacije, omaglicu, somnolenciju, umor, sinkopu i zamućeni vid (vidjeti dio 4.8).
English: Very common: Insomnia;
Croatian: Vrlo često: insomnija;
English: Insomnia may be minimised by administering Neofordex in the morning.
Croatian: Nesanica se može smanjiti primjenom lijeka Neofordex ujutro.
English: In extremely rare cases, a tendon may rupture.
Croatian: U iznimno rijetkim slučajevima može doći i do rupture tetive.
English: If the patient experiences any thromboembolic events, treatment must be discontinued and standard anticoagulation therapy started.
Croatian: Ako se u bolesnika pojave bilo kakvi tromboembolijski događaji, liječenje se mora prekinuti, te je potrebno započeti standardnu antikoagulacijsku terapiju.
English: Studies in animals have shown reproductive toxicity (see section 5.3).
Croatian: Ispitivanja provedena na životinjama dokazala su reproduktivnu toksičnost (vidjeti dio 5.3).
English: The usual posology of dexamethasone is 40 mg once per day of administration.
Croatian: Uobičajeno doziranje deksametazona iznosi 40 mg jednom na dan primjene.
English: This medicine does not require any special storage conditions.
Croatian: Ovaj lijek ne zahtjeva posebne uvjete čuvanja.
English: The dose and administration frequency varies with the therapeutic protocol and the associated treatment(s).
Croatian: Doza i učestalost primjene ovise o terapijskom protokolu i povezanom(im) liječenju(ima).
English: It is characterized by excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein only (free immunoglobulin monoclonal κ and λ light chains).
Croatian: Karakterizirana je prekomjernim brojem abnormalnih stanica plazme u koštanoj srži i prekomjernom proizvodnjom samo intaktnog monoklonskog imunoglobulina (IgG, IgA, IgD, or IgE) ili Bence-Jones proteina (slobodni monoklonski κ i λ lagani lanaci imunoglobulina).
English: Very common: may affect more than 1 in 10 people
Croatian: Vrlo često: javljaju se u više od 1 na 10 osoba
English: Particular care is needed when treating patients with glaucoma (or family history of glaucoma) as well as when treating patients with ocular herpes simplex, because of possible corneal perforation.
Croatian: Potrebno je obratiti posebnu pozornost pri liječenju bolesnika s glaukomom (ili obiteljskom anamnezom glaukoma) kao i prilikom liječenja bolesnika s očnim herpes simpleksom, jer je moguća perforacija rožnice.
English: − Epileptic fits;
Croatian: Epileptički napadaji;
English: • With digitalis, as hypokalaemia enhances the toxic effects of digitalis.
Croatian: • s digitalisom, budući da hipokalemija pojačava toksično djelovanje digitalisa.
English: Patients and physicians are advised to be observant for the signs and symptoms of thromboembolism.
Croatian: Bolesnicima i liječnicima se savjetuje da budu na oprezu kako bi uočili znakove i simptome tromboembolije.
English: Patients and/or carers should be warned that potentially severe psychiatric adverse reactions may occur with systemic steroids (see section 4.8).
Croatian: Potrebno je upozoriti bolesnike i/ili skrbnike da u slučaju terapije sistemskim steroidima mogu nastupiti ozbiljne psihijatrijske nuspojave (vidjeti dio 4.8).
English: Treatment with a high-dose corticosteroid may reduce your body's ability to fight infection.
Croatian: Liječenje visokim dozama kortikosteroida može smanjiti sposobnost tijela da se brani od infekcije.
English: However, antithrombotic prophylaxis with low-dose acetylsalicylic acid is possible.
Croatian: No, moguća je antitrombotska profilaksa s niskom dozom acetilsalicilatne kiseline.
English: Dexamethasone is transported by the P-glycoprotein (also known as MDR1).
Croatian: Deksametazon se prenosi P-glikoproteinom (također poznatim pod nazivom MDR1).
English: • With fluoroquinolones, due to possibly increased risk of tendonitis and, in exceptional cases, rupture of the affected tendon, particularly after long-term treatment.
Croatian: • s fluorokinolonima, zbog mogućeg povećanog rizika od tendonitisa i, u iznimnim slučajevima, rupture zahvaćene tetive, posebice nakon dugotrajnog liječenja.
English: Vaccinations with inactivated vaccines are usually possible.
Croatian: Najčešće je moguće provoditi cijepljenja neaktivnim cjepivima.
English: Based on human experience, dexamethasone is suggested to cause congenital malformations, particularly intra-uterine growth retardation and rarely neonatal adrenal insufficiency, when administered during pregnancy.
Croatian: Na temelju iskustva u ljudi, postoje naznake da deksametazon uzrokuje kongenitalne malformacije, posebice zaostajanja u intrauterinom rastu ploda, a rijetko i neonatalnu adrenalnu insuficijenciju, ako se primjenjuje tijekom trudnoće.
English: Treatment with high-dose dexamethasone increases the risk of developing serious infections, in particular due to bacteria, yeasts and/or parasites.
Croatian: Liječenje velikom dozom deksametazona povećava rizik od razvoja ozbiljnih infekcija, posebice zbog bakterije, kvasaca i/ili parazita.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Neofordex in all subsets of the paediatric population in multiple myeloma (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Neofordex u svim podskupinama pedijatrijske populacije oboljele od multiplog mijeloma (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: - The other ingredients are lactose monohydrate, microcrystalline cellulose, magnesium stearate and colloidal anhydrous silica (see section 2).
Croatian: - Drugi sastojci su laktoza hidrat, mikrokristalična celuloza, magnezijev stearat i koloidni bezvodni silicijev dioksid (vidjeti dio 2.).
English: Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regulation of Nuclear Factor-κB activity and an activation of caspase-9 through second mitochondria-derived activator of caspase (Smac; an apoptosis promoting factor) release.
Croatian: Dokazano je da deksametazon inducira smrt stanica multiplog mijeloma (apoptoza) putem snižavanja aktivnosti nuklearnog faktora-κB i aktiviranjem kaspaze-9 otpuštanjem drugog aktivatora kaspaze dobivenog iz mitohondrija (Smac; faktora koji promiče apoptozu).
English: You should also tell your doctor if you have had tuberculosis or if you have stayed in regions where roundworm infections are common.
Croatian: Morate obavijestiti svojeg liječnika i ako ste bolovali od tuberkuloze ili ako ste boravili u područjima u kojima su česte infekcije crvima naziva oblići .
English: FN was associated with dose interruption in 3.7% of patients, and with dose reduction in 1.3% of patients, and with no treatment discontinuations.
Croatian: FN je bila povezana s prekidima u doziranju u 3,7 % bolesnika i smanjenjem doze u 1,3 % bolesnika te bez prekida liječenja.
English: Glucocorticoid therapy may reduce the effect of anti-diabetic and antihypertensive treatment.
Croatian: Terapija glukokortikoidima može smanjiti djelovanje liječenja protiv dijabetesa i antihipetenzivnog liječenja.
English: Signs of a developing infection may be masked by dexamethasone therapy.
Croatian: Znakovi dobivanja infekcije mogu biti maskirani terapijom deksametazona.
English: Other MDR transporters may also have a role in dexamethasone transport.
Croatian: Drugi MDR prijenosnici mogu također imati ulogu u prijenosu deksametazona.
English: Less common but serious adverse reactions include: pneumonia and other infections and psychiatric disorders (see section 4.4).
Croatian: Manje česte no ozbiljne nuspojave uključuju: upalu pluća i druge infekcije te psihijatrijske poremećaje (vidjeti dio 4.4).
English: This includes any possible side effects not listed in this leaflet.
Croatian: To uključuje i svaku moguću nuspojavu koja nije navedena u ovoj uputi.Pogledajte dio 4.
English: No dose adjustment is needed in the treatment of multiple myeloma.
Croatian: Nije potrebna prilagodba doze u liječenju multiplog mijeloma.
English: Active viral disease (especially viral hepatitis, herpes, varicella, shingles).
Croatian: Aktivne virusne bolesti (posebice virusni hepatitis, herpes, varicela, herpes zoster).
English: This is particularly important if you notice signs of pneumonia: cough, fever, shortness of breath and chest pain.
Croatian: Ovo je posebno važno ako uočite znakove upale pluća: kašalj, groznicu, nedostatak zraka ili bol u prsima.
English: When thalidomide, lenalidomide or pomalidomide is used, particular attention to pregnancy testing and prevention requirements is needed.
Croatian: Ako se koriste talidomid, lenalidomid ili pomalidomid, posebna se pozornost mora obratiti na testiranje na trudnoću, kao i provođenje prevencije.
English: Patient at high risk of TLS, such as patients with high proliferative rate, high tumour burden, and high sensitivity to cytotoxic agents, should be monitored closely and appropriate precaution taken.
Croatian: Bolesnici s visokim rizikom od razvoja TLS-a, poput bolesnika s visokom stopom proliferacije, velikim tumorskim opterećenjem i izrazitom osjetljivošću na citotoksične lijekove, trebali bi biti pažljivo praćeni uz prikladne mjere opreza.
English: Other cytochrome P450 isoenzymes may also play a role in dexamethasone biotransformation.
Croatian: Ostali izoenzimi citokroma P450 mogu također imati ulogu u biotransformaciji deksametazona.