FrancophonIA/ELRC3.0 huggingface dataset:
English: The median baseline CD4+ cell count was 628 x 10
Danish: Medianen for CD4+-celletallet ved baseline var 628 x 10
English: Although darunavir has not been studied in patients with renal impairment, population pharmacokinetic analysis showed that the pharmacokinetics of darunavir were not significantly affected in HIV infected patients with moderate renal impairment (eGFRCG between 30-60 mL/min, N = 20) (see sections 4.2 and 4.4).
Danish: Selvom darunavir ikke er blevet undersøgt hos patienter med nedsat nyrefunktion, viste en populationsfarmakokinetisk analyse, at darunavirs farmakokinetik ikke var signifikant påvirket hos hiv-inficerede patienter med moderat nedsat nyrefunktion (eGFRCG mellem 30 og 60 ml/min, N=20) (se pkt.
English: Week 48 and 96 virologic outcomes in the EMERALD trial are provided in Table 6.
Danish: De virologiske resultater fra uge 48 og 96 i EMERALD-studiet er vist i tabel 6.
English: Over 96 weeks of treatment in the Phase 3 studies TMC114FD2HTX3001 (AMBER) in treatmentnaïve patients and TMC114IFD3013 (EMERALD) in virologically suppressed treatment-experienced patients, resistance testing was performed on samples from patients experiencing protocol-defined virologic failure (PDVF) and who had HIV-1 RNA ≥400 copies/mL at failure or at later time points.
Danish: Over 96 ugers behandling i fase 3-studierne TMC114FD2HTX3001 (AMBER) hos behandlingsnaive patienter og TMC114IFD3013 (EMERALD) hos virologisk supprimerede, behandlingserfarne patienter blev der udført resistenstestning på prøver fra patienter, som oplevede protokoldefineret virologisk svigt (PDVF), og som havde hiv-1 RNA ≥ 400 kopier/ml ved svigtet eller på senere tidspunkter.
English: Symtuza is, therefore, contraindicated in patients with severe hepatic impairment.
Danish: Symtuza er derfor kontraindiceret til patienter med svært nedsat leverfunktion.
English: In HIV infected patients with severe immune deficiency at the time of initiation of CART, an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Danish: Hos hivinficerede patienter med svær immuninsufficiens på tidspunktet for påbegyndelse af CART kan der opstå en inflammatorisk reaktion på asymptomatiske eller residuale opportunistiske patogener, som kan forårsage alvorlige kliniske tilstande eller forværring af symptomer.
English: Symtuza might increase sugar levels in the blood.
Danish: Symtuza kan forhøje blodsukkerniveauet.
English: HIV-1 Treatment experienced Patients
Danish: Hiv-1-behandlingserfarne patienter
English: The antiviral activity of emtricitabine against laboratory and clinical isolates of HIV-1 was assessed in lymphoblastoid cell lines, the MAGI CCR5 cell line, and PBMCs.
Danish: Emtricitabins antivirale aktivitet mod laboratorie- og kliniske isolater af hiv-1 blev vurderet i lymfoblastoide cellelinjer, MAGI CCR5-cellelinjen og PBMC'er.
English: However,the safety of components of Symtuza was evaluated through the clinical study TMC114-C230 (N = 12) for darunavir with ritonavir and GS-US-292-0106 (N = 50) for a fixed dose combination containing elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide.
Danish: Sikkerheden af komponenterne i Symtuza blev imidlertid evalueret i det kliniske studie TMC114-C230 (N=12) for darunavir med ritonavir og GS-US-292-0106 (N=50) for en fastdosiskombination indeholdende elvitegravir, cobicistat, emtricitabin og tenofoviralafenamid.
English: General disorders and administration site conditions common asthenia, fatigue
Danish: Almene symptomer og reaktioner på administrationsstedet almindelig asteni, træthed
English: There have been reports of increased spontaneous bleeding in haemophiliac patients receiving antiretroviral protease inhibitors (see section 4.4).
Danish: Der har været rapporter om hyppigere spontane blødninger hos patienter med hæmofili, der fik antiretrovirale proteasehæmmere (se pkt.
English: Darunavir exhibits activity against laboratory strains and clinical isolates of HIV-1 and laboratory strains of HIV-2 in acutely infected T-cell lines, human PBMCs and human monocytes/macrophages with median EC50 values ranging from 1.2 to 8.5 nM (0.7 to 5.0 ng/mL).
Danish: Darunavir udviser aktivitet mod laboratoriestammer og kliniske isolater af hiv-1 og laboratoriestammer af hiv-2 i akut inficerede T-cellelinjer, humane PBMC'er og humane monocytter/makrofager med mediane EC50-værdier i intervallet fra 1,2 til 8,5 nM (0,7 til 5,0 ng/ml).
English: When your supply of Symtuza starts to run low, get more from your doctor or pharmacist.
Danish: Når du er ved at løbe tør for Symtuza, skal du bede om mere fra lægen eller på apoteket.
English: In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Danish: Udover disse opportunistiske infektioner kan autoimmune lidelser (en tilstand, der opstår, når immunsystemet angriber sundt kropsvæv) også opstå, efter du er begyndt at tage medicin til behandling af din hiv-infektion.
English: The below list of examples of drug drug interactions is not comprehensive and therefore the label of each drug that is co-administered with Symtuza should be consulted for information related to the route of metabolism, interaction pathways, potential risks, and specific actions to be taken with regards to co-administration.
Danish: Derfor skal mærkningen af hvert lægemiddel, som administreres sammen med Symtuza, gennemgås for information releteret til metabolismevejen, interaktions mekanismerne, potentielle riscici og konkrete forholdsregler, som skal tages i forbindelse med co-administration.
English: In the study GS-US-292-0106, the efficacy, safety, and pharmacokinetics of emtricitabine and tenofovir alafenamide were evaluated in an open-label study in which 50 HIV-1 infected, treatment-naïve adolescents received emtricitabine and tenofovir alafenamide (10 mg) given with elvitegravir and cobicistat as a fixed-dose combination tablet.
Danish: I studie GS-US-292-0106 blev virkningen, sikkerheden og farmakokinetikken af emtricitabin og tenofoviralafenamid evalueret i et åbent studie, i hvilket 50 hiv-1-inficerede behandlingsnaive unge fik emtricitabin og tenofoviralafenamid (10 mg) med elvitegravir og cobicistat som en fastdosiskombinationstablet.
English: In some patients with advanced HIV infection and who had unusual infections due to a weakened immune system (opportunistic infection), signs and symptoms of inflammation from previous infections may occur soon after you start HIV treatment.
Danish: Hos nogle patienter med fremskreden hiv-infektion, som havde usædvanlige infektioner på grund af et svækket immunforsvar (opportunistiske infektioner), kan tegn og symptomer på betændelse fra tidligere infektioner vise sig kort efter, at du har påbegyndt hiv-behandling.
English: Fluticasone
Danish: Fluticason
English: However, there are pharmacokinetic data for the different components of Symtuza, indicating that doses of 800 mg darunavir, 150 mg cobicistat, 200 mg emtricitabine and 10 mg tenofovir alafenamide result in similar exposures in adults and adolescents aged 12 years and older, weighing at least 40 kg.
Danish: Der findes imidlertid farmakokinetiske data for de forskellige komponenter i Symtuza, der indikerer, at doser på 800 mg darunavir, 150 mg cobicistat, 200 mg emtricitabin og 10 mg tenofoviralafenamid resulterer i tilsvarende eksponeringer hos voksne og unge fra alderen 12 år og op, som vejer mindst 40 kg.
English: HIV-1 Treatment naïve Patients
Danish: Hiv-1-behandlingsnaive patienter
English: Nucleoside and nucleotide analogues have been demonstrated in vitro and in vivo to cause a variable degree of mitochondrial damage.
Danish: Det er påvist in vitro og in vivo, at nukleosid- og nukleotidanaloger i forskellig grad forårsager skader på mitokondrierne.
English: Concomitant use of a HMG CoA reductase inhibitor and Symtuza may increase plasma concentrations of the lipid lowering agent, which may lead to adverse reactions such as myopathy.
Danish: Samtidig brug af en HMG-CoAreduktasehæmmer og Symtuza kan øge plasmakoncentrationen af det lipidsænkende stof, hvilket kan medføre bivirkninger såsom myopati.
English: Nizatidine
Danish: Nizatidin
English: In the Phase 2/3 trials in treatment-naïve patients, 12.7% (59/465) of patients receiving Symtuza experienced rash (most of which were grade 1), 1.5% (7/465) of patients discontinued treatment due to rash, of whom one for rash and hypersensitivity.
Danish: I fase 2/3-studierne af behandlingsnaive patienter oplevede 12,7 % (59/465) af de patienter, der fik Symtuza, udslæt (af hvilke de fleste var af grad 1), 1,5 % (7/465) af patienterne afbrød behandlingen på grund af udslæt, af hvilke én både havde udslæt og overfølsomhed.
English: The active substances are darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.
Danish: Aktive stoffer: darunavir, cobicistat, emtricitabin og tenofoviralafenamid.
English: Concomitant use of everolimus and Symtuza is not recommended.
Danish: Samtidig brug af everolimus og Symtuza frarådes.
English: A trial of the pharmacokinetics of cobicistat was performed in non-HIV-1 infected subjects with severe renal impairment (eGFRCG below 30 mL/min).
Danish: Et forøsg med farmakokinetikken af cobicistat blev udført hos ikke-hiv-1-inficerede personer med svært nedsat nyrefunktion (eGFRCG under 30 ml/min).
English: Tenofovir diphosphate inhibits HIV replication through incorporation into viral DNA by the HIV RT, which results in DNA chain-termination.
Danish: Tenofovirdiphosphat hæmmer hiv-replikationen ved optagelsen i det virale DNA, der medieres af hiv-RT, hvilket resulterer i DNA-kædeafslutning.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with Symtuza is not recommended.
Danish: Co-administration of tadalafil til behandling af pulmonal arteriel hypertension med Symtuza frarådes.
English: Co-administration of tenofovir alafenamide with other medicinal products that inhibit P-gp (e.g., cobicistat, ritonavir, ciclosporin) are expected to increase the absorption and plasma concentration of tenofovir alafenamide.
Danish: Co-administration af tenofoviralafenamid med andre lægemidler, som hæmmer P-gp (f.eks. cobicistat, ritonavir, ciclosporin), forventes at øge absorptionen og plasmakoncentrationen af tenofoviralafenamid.
English: Please contact your doctor whenever you develop a rash.
Danish: Kontakt altid lægen, når du får udslæt.
English: Symtuza should not be used in paediatric patients below 3 years of age because of safety concerns (see sections 4.4 and 5.3).
Danish: Symtuza bør ikke anvendes til pædiatriske patienter under 3 år på grund af problemstillinger vedrørende sikkerhed (se pkt.
English: Patients with chronic hepatitis B or C treated with antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Danish: Patienter med kronisk hepatitis B eller C, som er i antiretroviral behandling, har en øget risiko for alvorlige og potentielt dødelige leverbivirkninger.
English: Viruses selected in these conditions and showing decreased susceptibility to darunavir (range: 23-50-fold) harboured 2 to 4 amino acid substitutions in the protease gene.
Danish: De selekterede vira kunne ikke vokse ved tilstedeværelse af darunavir-koncentrationer over 400 nM. Vira, der blev selekteret under disse betingelser, og som viste nedsat følsomhed over for darunavir (interval: 23-50 fold), indeholdt 2 til 4 aminosyresubstitutioner i proteasegenet.
English: Co-administration of Symtuza and these anticoagulants is not recommended.
Danish: Co-administration af Symtuza og disse antikoagulantia frarådes.
English: An increase in weight and in levels of blood lipids and glucose may occur during antiretroviral therapy.
Danish: Vægtøgning og forhøjede lipider og glucose i blodet kan forekomme under antiretroviral behandling.
English: Patients with pre-existing liver dysfunction, including chronic hepatitis B or C, have an increased risk for liver function abnormalities including severe and potentially fatal hepatic adverse reactions.
Danish: Patienter med eksisterende leverdysfunktion, herunder kronisk hepatitis B eller C, har en øget risiko for leverfunktionsanomalier, herunder alvorlige og potentielt dødelige leverbivirkninger.
English: Cross-resistance in HIV-1 infected, treatment-naïve and virologically suppressed patients
Danish: Krydsresistens hos hiv-1-inficerede, behandlingsnaive og virologisk supprimerede patienter
English: In HIV infected patients with severe immune deficiency at the time of CART, an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Danish: Hos hiv-inficerede patienter med svær immundefekt på tidspunktet for initiering af CART kan der opstå en inflammatorisk reaktion på asymptomatiske eller resterende opportunistiske infektioner.
English: No clinically relevant differences in tenofovir alafenamide, or tenofovir pharmacokinetics were observed between healthy subjects and patients with severe renal impairment (eGFRCG > 15 but < 30 mL/min) in studies of tenofovir alafenamide.
Danish: Der blev ikke observeret nogen klinisk relevante forskelle i farmakokinetikken for tenofoviralafenamid eller tenofovir hos raske personer og hos patienter med svært nedsat nyrefunktion (eGFRCG > 15 men < 30 ml/min) i studier af tenofoviralafenamid.
English: Alternative or additional contraceptive measures are recommended when oestrogen based contraceptives are coadministered with Symtuza.
Danish: Alternativ eller yderligere prævention anbefales ved coadministration af østrogenbaseret prævention med Symtuza.
English: The main adverse reactions reported are haematological disorders (anaemia, neutropenia) and metabolic disorders (hyperlactataemia, hyperlipasaemia).
Danish: De hyppigst indrapporterede bivirkninger er hæmatologiske forstyrrelser (anæmi, neutropeni) og metaboliske forstyrrelser (hyperlactatæmi, hyperlipasæmi).
English: Symtuza can be co-administered with proton pump inhibitors without dose adjustments.
Danish: Symtuza kan co-administreres med protonpumpehæmmere uden dosisjustering.
English: FDA Snapshot Outcome HIV-1 RNA < 50 copies/mL Virologic Failure
Danish: FDA-snapshot-resultater Hiv-1 RNA <50 kopier/ml Virologisk svigt
English: Clinical monitoring of therapeutic and adverse effects is recommended when these medicines are co-administered with Symtuza.
Danish: Klinisk monitorering af terapeutisk virkning og bivirkninger anbefales, når disse lægemidler administreres samtidigt med Symtuza.
English: (CYP3A inhibition) Co-administration of ciclosporin is expected to increase plasma concentrations of tenofovir alafenamide.
Danish: (CYP3A-hæmning) Co-administration af ciclosporin forventes at øge plasmakoncentrationen af tenofoviralafenamid.
English: If a dose of Symtuza is missed within 12 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of Symtuza with food as soon as possible.
Danish: Hvis en dosis Symtuza glemmes i op til 12 timer efter det tidspunkt, hvor den sædvanligvis tages, skal patienterne informeres om snarest muligt at tage den ordinerede dosis Symtuza sammen med mad.
English: In double-blind Phase 3 Trial TMC114FD2HTX3001 (AMBER), treatment-naïve patients were randomised to receive either Symtuza (N = 362) or a combination of fixed-dose combination of darunavir and cobicistat and fixed-dose combination of emtricitabine and tenofovir disoproxil fumarate (F/TDF) (N = 363) once daily.
Danish: I det dobbeltblindede fase-3-studie TMC114FD2HTX3001 (AMBER) blev behandlingsnaive patienter randomiseret til at få enten Symtuza (N = 362) eller en kombination af en fastdosis-kombination af darunavir og cobicistat og en fastdosis-kombination af emtricitabin og tenofovirdisoproxilfumarat (F/TDF) (N = 363) en gang dagligt.
English: Week 48 and 96 Virologic Outcomes in EMERALD Trial Week 48
Danish: Virologiske resultater ved uge 48 og 96 i EMERALD-studiet Uge 48
English: Therefore, therapy with Symtuza should not be initiated during pregnancy, and women who become pregnant during therapy with Symtuza should be switched to an alternative regimen (see sections 4.2 and 4.4).
Danish: Behandling med Symtuza bør derfor ikke påbegyndes under graviditet, og kvinder, som bliver gravide under behandling med Symtuza, bør skiftes til et alternativt regime (se pkt.
English: As Symtuza contains darunavir, cobicistat, emtricitabine, and tenofovir alafenamide, the adverse reactions associated with each of the individual compounds may be expected.
Danish: Da Symtuza indeholder darunavir, cobicistat, emtricitabin og tenofoviralafenamid, kan der forventes de samme bivirkninger som dem, der er forbundet med de enkelte stoffer.
English: Treatment with darunavir/cobicistat 800/150 mg once daily during pregnancy results in low darunavir exposure (see Table 8).
Danish: Behandling med 800/150 mg darunavir/cobicistat en gang dagligt under graviditet fører til lav eksponering for darunavir (se tabel 8).
English: 6 cells/L),
Danish: 6 celler/l).
English: Patients had a median age of 46 years (range 19-78), 82% were male, 75.5% White, 20.9% Black, and 2.3% Asian.
Danish: Patienterne havde en medianalder på 46 år (interval 19-78), 82 % var mænd, 75,5 % hvide, 20,9 % sorte og 2,3 % asiater.
English: No drug interaction trials have been performed using Symtuza.
Danish: Der er ikke udført interaktionsstudier med Symtuza.
English: The most frequent (> 5%) adverse reactions reported in suppressed treatment-experienced patients (EMERALD Study TMC114IFD3013, Week 96 analysis) were diarrhoea (10.5%), headache (10.4%), arthralgia (7.7%), abdominal pain (7.5%), fatigue (5.9%), and rash (5.1%).
Danish: De hyppigst rapporterede bivirkninger (> 5 %) hos supprimerede, behandlingserfarne patienter (EMERALD-studiet TMC114IFD3013, uge 96-analyse) var diarré (10,5 %), hovedpine (10,4 %), artralgi (7,7 %), abdominalsmerter (7,5 %), træthed (5,9 %) og udslæt (5,1 %).
English: Caution is warranted and therapeutic concentration monitoring, if available, is recommended for these antiarrhythmics when co-administered with Symtuza.
Danish: Forsigtighed tilrådes, og monitorering af den terapeutiske koncentration anbefales om muligt, når disse antiarytmika administreres samtidig med Symtuza.
English: Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets
Danish: Symtuza 800 mg/150 mg/200 mg/10 mg filmovertrukne tabletter
English: Metabolism and nutrition disorders common diabetes mellitus, anorexia, hypercholesterolaemia, low density lipoprotein increased, hypertriglyceridaemia, hyperlipidaemia, dyslipidaemia uncommon hyperglycaemia
Danish: Metabolisme og ernæring almindelig diabetes mellitus, anoreksi, hyperkolesterolæmi, forhøjet LDL-kolesterol, hypertriglyceridæmi, hyperlipidæmi, dyslipidæmi ikke almindelig hyperglykæmi
English: In the Phase 3 trial in suppressed treatment-experienced patients (EMERALD Study TMC114IFD3013), 5.1% (39/763) of patients receiving Symtuza experienced rash (most of which were grade 1), none discontinued treatment due to rash.
Danish: I fase 3-studiet hos supprimerede, behandlingserfarne patienter (EMERALD-studiet TMC114IFD3013) oplevede 5,1 % (39/763) af de patienter, der fik Symtuza, udslæt (af hvilke de fleste var af grad 1), ingen afbrød behandlingen på grund af udslæt.
English: The mean baseline plasma HIV-1 RNA and the median baseline CD4+ cell count were 4.48 log10 copies/mL (SD = 0.61) and 453 x 10
Danish: Gennemsnitligt baseline plasma hiv-1 RNA og medianen for CD4+-celletal ved baseline var henholdsvis 4,48 log10 kopier/ml (SD = 0,61) og 453 x 10
English: When used for birth control, non-hormonal contraception methods are recommended.
Danish: I forbindelse med svangerskabsforebyggelse anbefales det, at du anvender prævention, der ikke indeholder hormoner.
English: Therefore, co-administration of Symtuza and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Danish: Co-administration af Symtuza og sildenafil til behandling af pulmonal arteriel hypertension er derfor kontraindiceret (se pkt.
English: • muscle pain, muscle cramps or weakness
Danish: • muskelsmerter, muskelkramper eller muskelsvaghed
English: HMG CO-A REDUCTASE INHIBITORS Atorvastatin
Danish: HMG-CO-A-REDUKTASEHÆMMERE Atorvastatin
English: Emerging resistance in HIV-1 infected, treatment-naïve and virologically suppressed patients
Danish: Ny resistens hos hiv 1-inficerede, behandlingsnaive og virologisk supprimerede patienter
English: (drug) hypersensitivity uncommon immune reconstitution inflammatory syndrome
Danish: (lægemiddel)overfølsomhed ikke almindelig immunrekonstitutionsinflammatorisk syndrom
English: Darunavir is an inhibitor of CYP3A, a weak inhibitor of CYP2D6 and an inhibitor of P-gp.
Danish: Darunavir er en CYP3A-hæmmer, en svag CYP2D6-hæmmer og en P-gp-hæmmer.
English: What Symtuza looks like and contents of the pack Yellow to yellowish-brown capsule shaped film-coated tablet, mentioning “8121” on one side and “JG” on the other side.
Danish: Gul til gullig-brun kapselformet, filmovertrukket tablet, hvor der står „8121“ på den ene side og „JG“ på den anden side.
English: Discontinuation of Symtuza therapy in patients co-infected with HIV and HBV may be associated with severe acute exacerbations of hepatitis.
Danish: Afbrydelse af behandlingen med Symtuza hos patienter med samtidig hiv- og HBV-infektion kan føre til alvorlig, akut forværring af hepatitis.
English: At baseline, median plasma HIV-1 RNA was 4.7 log10 copies/mL, median CD4+ cell count was 456 cells/mm
Danish: Ved baseline var gennemsnitligt hiv-1 RNA i plasma 4,7 log10 kopier/ml, middel CD4+-celletal var 456 celler/mm
English: (CYP3A induction) Symtuza is expected to increase bosentan plasma concentrations.
Danish: (CYP3A-induktion) Symtuza forventes at øge plasmakoncentrationen af bosentan.
English: Based on theoretical considerations co-administration of DRV/COBI with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Danish: Baseret på teoretiske overvejelser kan co-administration af DRV/COBI med disse antikoagulantia øge koncentrationen af antikoagulansen, hvilket kan medføre en øget blødningsrisiko.
English: The most frequent (> 5%) adverse reactions reported in treatment-naïve patients in the Phase 2 (GSUS-299-0102) and Phase 3 Study (AMBER, TMC114FD2HTX3001, Week 96 analysis) were diarrhoea (22.6%), headache (13.1%), rash (12.7%), nausea (9.7%), fatigue (8.0%), and abdominal pain (5.8%).
Danish: De hyppigst rapporterede bivirkninger (> 5 %) hos behandlingsnaive patienter i fase 2-studiet (GS299-0102) og fase 3-studiet (AMBER, TMC114FD2HTX3001, uge 96-analyse) var diarré (22,6 %), hovedpine (13,1 %), udslæt (12,7 %), kvalme (9,7 %), træthed (8,0 %) og abdominalsmerter (5,8 %).
English: Monitor for fesoterodine or solifenacin adverse reactions, dose reduction of fesoterodine or solifenacin may be necessary.
Danish: Dosisreduktion af fesoterodin eller solifenacin kan være nødvendig.
English: The recommended dose for adults and adolescents 12 years of age and older, who weigh at least 40 kg is one tablet each day with food.
Danish: Den anbefalede dosis til voksne og unge i alderen 12 år og derover, der vejer mindst 40 kg, er én tablet, der tages én gang dagligt sammen med mad.
English: Tenofovir alafenamide is a nucleotide reverse transcriptase inhibitor (NtRTI) and phosphonoamidate prodrug of tenofovir (2'-deoxyadenosine monophosphate analogue).
Danish: Tenofoviralafenamid er en nukleotid revers transkriptasehæmmer (NtRTI) og et phosphonoamidatprodrug for tenofovir (2'-deoxyadenosinmonophosphat-analog).
English: • vomiting, pain or swelling of the belly, indigestion, flatulence (wind)
Danish: • opkastning, mavesmerter eller -udspiling, fordøjelsesbesvær, luft i tarmene
English: What you need to know before you take Symtuza
Danish: Det skal du vide, før du begynder at tage Symtuza
English: Rash is a common adverse drug reaction in patients treated with darunavir.
Danish: Udslæt er en almindelig bivirkning hos patienter, der er i behandling med darunavir.