FrancophonIA/ELRC3.0 huggingface dataset:
English: The effect of linaclotide and its metabolites to inhibit the common intestinal enzymes (CYP2C9 and CYP3A4) and liver enzymes (CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4) or to induce liver enzymes (CYP1A2, 2B6, and 3A4/5) was investigated in vitro.
Croatian: Učinak linaklotida i njegovih metabolita na inhibiciju uobičajenih intestinalnih enzima (CYP2C9 i CYP3A4) i jetrenih enzima (CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 i 3A4) ili na indukciju jetrenih enzima (CYP1A2, 2B6 i 3A4/5) je ispitivan in vitro.
English: The capsule should be taken 30 minutes before a meal (see section 4.2).
Croatian: Kapsula se mora uzeti 30 minuta prije obroka (vidjeti dio 4.2).
English: INFORMATION IN BRAILLE constella 290 mcg
Croatian: 16. PODACI NA BRAILLEOVOM PISMU constella 290 mcg
English: Clinical studies to determine the impact of age and gender on the clinical pharmacokinetics of linaclotide have not been conducted because it is rarely detectable in plasma.
Croatian: Klinička ispitivanja za određivanje utjecaja dobi i spola na kliničku farmakokinetiku linaklotida nisu provedena jer se on rijetko može detektirati u plazmi.
English: There are limited data in elderly patients (see section 5.1).
Croatian: Podaci o bolesnicima starije dobi su ograničeni (vidjeti dio 5.1).
English: Take also special care if you have severe or prolonged diarrhoea and an additional disease, such as high blood pressure, previous disease of the heart and blood vessels (e.g. such as previous heart attacks) or diabetes.
Croatian: Također, posebne mjere opreza su potrebne ako imate teški ili produljeni proljev i dodatnu bolest, kao što je visok krvni tlak, prijašnje bolesti srca ili krvožilnog sustava (npr. prethodni srčani udari) ili šećernu bolest.
English: Should an overdose occur, the patient should be treated symptomatically and supportive measures instituted as required.
Croatian: U slučaju predoziranja, bolesnik se mora liječiti simptomatski i prema potrebi provesti suportivne mjere.
English: Because of the higher risk of diarrhoea seen in the clinical trials (see section 4.8), special attention should be given to these patients and the treatment benefitrisk ratio should be carefully and periodically assessed.
Croatian: Radi većeg rizika od proljeva koji je opažen u kliničkim ispitivanjima (vidjeti dio 4.8), mora se posvetiti posebnu pažnju takvim bolesnicima, a mora se i pažljivo i periodički procijeniti odnos između koristi i rizika liječenja.
English: In rare and more severe cases, this may - as a consequence - lead to the occurrence of dehydration, hypokalaemia, blood bicarbonate decrease, dizziness, and orthostatic hypotension.
Croatian: U rijetkim i težim slučajevima, kao posljedica proljeva moguća je pojava dehidracije, hipokalemije, smanjenja bikarbonata u krvi, omaglice i ortostatske hipotenzije.
English: The most frequently reported adverse reaction associated with Constella therapy was diarrhoea, mainly mild to moderate in intensity, occurring in less than 20% of patients.
Croatian: Najčešće prijavljena nuspojava povezana s terapijom Constellom je bio proljev, najčešće blagog do umjerenog intenziteta, a pojavljivao se u manje od 20% bolesnika.
English: It is unknown whether linaclotide is excreted in human milk.
Croatian: Nije poznato izlučuje li se linaklotid u majčino mlijeko.
English: Linaclotide is metabolised locally within the gastrointestinal tract to its active primary metabolite, destyrosine.
Croatian: Linaklotid se metabolizira lokalno unutar gastrointestinalnog trakta na svoj aktivni primarni metabolit, destirozin.
English: 28 capsules.
Croatian: 28 kapsula.
English: Constella has no or negligible influence on the ability to drive and use machines.
Croatian: Constella ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: They should be instructed to inform their physician if severe or prolonged diarrhoea or lower gastrointestinal bleeding occurs (see section 4.8).
Croatian: Mora ih se uputiti da informiraju svog liječnika u slučajevima pojave teškog ili produljenog proljeva odnosno krvarenja iz donjeg gastrointestinalnog trakta (vidjeti dio 4.8).
English: Results of this study showed that neither peptide is an inhibitor of the common efflux and uptake transporters studied at clinically relevant concentrations.
Croatian: Rezultati ovog ispitivanja su pokazali da niti jedan peptid nije inhibitor uobičajenih transportera izbacivanja i unosa ispitivanih u klinički relevantnim koncentracijama.
English: Effect of linaclotide on IBS-C symptoms during the first 12 weeks of treatment in the pooled phase 3 efficacy clinical studies (studies 1 and 2).
Croatian: Učinak linaklotida na simptome IBS-C-a za vrijeme prvih 12 tjedana liječenja u objedinjenoj fazi III kliničkog ispitivanja djelotvornosti (ispitivanja 1 i 2).
English: • bleeding from the bowel or rectum including bleeding from piles/haemorrhoids
Croatian: • krvarenje iz crijeva ili rektuma, uključujući krvarenje iz hemoroida
English: The efficacy of linaclotide has been established in double-blind placebo-controlled studies for up to 6 months.
Croatian: Djelotvornost linaklotida je ustanovljena u dvostruko slijepim, placebom kontroliranim ispitivanjima u trajanju do 6 mjeseci.
English: In a study in healthy volunteers receiving a single dose of 2,897 micrograms (up to 10-fold the recommended therapeutic dose) the safety profile in these subjects was consistent with that in the overall population, with diarrhoea being the most commonly reported adverse event.
Croatian: Ispitivanja na zdravim dobrovoljcima koji su primili jednokratnu dozu od 2897 mikrograma (do 10 puta više od preporučene terapijske doze) su kod takvih ispitanika pokazala sigurnosni profil u skladu s ukupnom populacijom, a proljev je bio najčešće prijavljeni štetni događaj.
English: In one clinical study (study 1), 804 patients were treated with Constella 290 micrograms or placebo once daily for 26 weeks.
Croatian: U jednom kliničkom ispitivanju (ispitivanje 1), 804 bolesnika su liječena lijekom Constella 290 mikrograma ili placebom jedanput na dan tijekom 26 tjedana.
English: The recommended dose is one capsule (290 micrograms) once daily.
Croatian: Preporučena doza je jedna kapsula (290 mikrograma) jedanput na dan.
English: Special populations Patients with renal or hepatic impairment
Croatian: Posebne populacije Bolesnici s oštećenjem bubrežne ili jetrene funkcije
English: Patients with known or suspected mechanical gastrointestinal obstruction.
Croatian: Bolesnici koji imaju mehaničku gastrointestinalnu opstrukciju ili se sumnja na nju.
English: Patients should be aware of the possible occurrence of diarrhoea and lower gastrointestinal bleeding during treatment.
Croatian: Bolesnici moraju biti svjesni mogućih pojava proljeva i krvarenja iz donjeg gastrointestinalnog trakta za vrijeme liječenja.
English: Driving and using machines Constella will not affect your ability to drive or use machines
Croatian: Upravljanje vozilima i strojevima Constella neće utjecati na Vašu sposobnost upravljanja vozilima ili strojevima.
English: Diarrhoea is the most common adverse reaction and is consistent with the pharmacological action of the active substance.
Croatian: Proljev je najčešća nuspojava i u skladu je s farmakološkim djelovanjem aktivne tvari.
English: How Constella works
Croatian: Kako Constella djeluje
English: If you have not experienced improvement in your symptoms after 4 weeks of treatment, you should contact your doctor.
Croatian: Ako nakon 4 tjedna liječenja ne primijetite poboljšanje simptoma, obratite se svom liječniku.
English: For elderly patients, although no dose adjustment is required, the treatment should be carefully monitored and periodically re-assessed (see section 4.4).
Croatian: Iako nije potrebno prilagođavanje doze za bolesnike starije dobi, njihovo liječenje se mora pažljivo pratiti i periodično procijeniti (vidjeti dio 4.4).
English: Elderly patients
Croatian: Bolesnici starije dobi
English: These effects were reached at 1 week and sustained over the entire treatment periods.
Croatian: Ti učinci su postignuti u 1. tjednu liječenja te su se održali cijelo vrijeme trajanja liječenja.
English: Taking Constella immediately after a high fat breakfast resulted in more frequent and looser stools, as well as more gastrointestinal adverse events, compared with taking it in the fasted state.
Croatian: Uzimanje Constelle neposredno nakon doručka bogatog mastima je rezultiralo češćim i mekšim stolicama kao i s više gastrointestinalnih štetnih događaja, u usporedbi s uzimanjem natašte.
English: Constella produces more frequent bowel movements and diarrhoea (looser stools) when it is taken with food than when it is taken on an empty stomach (see section 3).
Croatian: Constella dovodi do češćeg pražnjenja crijeva i proljeva (mekše stolice) kad se uzima s hranom, nego kad se uzima na prazan želudac (pogledajte dio 3).
English: What Constella is and what it is used for
Croatian: Što je Constella i za što se koristi
English: As linaclotide is rarely detectable in plasma following therapeutic doses, standard distribution studies have not been conducted.
Croatian: Budući da se linaklotid rijetko otkriva u plazmi kod primjene terapijskih doza, nisu izvršena standardna distribucijska ispitivanja.
English: Linaclotide is a 14-amino acid synthetic peptide structurally related to the endogenous guanylin peptide family.
Croatian: Linaklotid je sintetički peptid koji sadrži 14 aminokiselina strukturno srodan sa skupinom endogenih gvanilin peptida.
English: Results of these studies showed that linaclotide and des-tyrosine metabolite are not inhibitors or inducers of the cytochrome P450 enzyme system.
Croatian: Rezultati ovih ispitivanja su pokazali da linaklotid i metabolit des-tirozin nisu inhibitori ili induktori enzimskog sustava citokroma P450.
English: The capsule should be taken at least 30 minutes before a meal (see section 4.5).
Croatian: Kapsulu se mora uzeti najmanje 30 minuta prije obroka (vidjeti dio 4.5).
English: Microcrystalline cellulose Hypromellose 4-6 mPa's - substitution type 2910 Calcium chloride dihydrate Leucine
Croatian: Sadržaj kapsule mikrokristalična celuloza hipromeloza 4-6 mPa.s - supstitucijski tip 2910 kalcijev klorid dihidrat leucin
English: Caution should be used when co-administering Constella with such medications.
Croatian: Potreban je oprez kada se Constella istodobno primjenjuje s tim lijekovima.
English: Pooled Phase III Efficacy clinical studies (Study 1 and 2) OC Approach (ITT Population)
Croatian: Objedinjena faza III kliničkih ispitivanja djelotvornosti (Ispitivanje 1 i 2) Opaženi slučajevi (ITT populacija)
English: Gastroenteritis viral
Croatian: Virusni gastroenteritis
English: All patients met Rome II criteria for IBS-C and were required to report a mean abdominal pain score of ≥ 3 on a 0-to-10-point numeric rating scale (criteria that correspond to a moderate to severe IBS population), < 3 complete spontaneous bowel movements and ≤ 5 SBMs per week during a 2-week baseline period.
Croatian: Svi bolesnici su ispunjavali kriterije Rome II za IBS-C te su prijavili srednju vrijednost intenziteta boli u abdomenu od ≥ 3 na numeričkoj ljestvici 0-10 (kriteriji koji odgovaraju umjerenom do jakom intenzitetu boli kod populacije s IBS-om), < 3 potpuna spontana pražnjenja crijeva i ≤ 5 spontanih pražnjenja crijeva tjedno za vrijeme početnog razdoblja u trajanju od 2 tjedna.
English: The characteristics of the patient population included in Phase 3 clinical trials were as follows: mean age of 43.9 years [range 18 - 87 years with 5.3% ≥ 65 years of age], 90.1% female.
Croatian: Karakteristike populacije bolesnika uključenih u fazu III kliničkih ispitivanja su bile sljedeće: prosječna dob 43,9 godina [raspon 18 - 87 godina s 5,3% ispitanika u dobi
English: Concomitant treatment with proton pump inhibitors, laxatives or NSAIDs may increase the risk of diarrhoea.
Croatian: Istodobno liječenje s inhibitorima protonske pumpe, laksativima ili nesteroidnim protuupalnim lijekovima (NSAIL) može povećati rizik od proljeva.
English: By attaching to this receptor, it blocks the sensation of pain and allows liquid to enter from the body into the gut, thereby loosening the stools and increasing your bowel movements.
Croatian: Vezanjem na taj receptor, blokira se osjećaj boli i dopušta propuštanje tekućine iz tijela u crijeva, što omekšava stolicu i povećava učestalost pražnjenja crijeva.
English: Do not use this medicine after the expiry date which is stated on the carton and the bottle after ¨EXP¨.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i boci iza oznake „Rok valjanosti“.
English: It is used to treat the symptoms of moderate to severe irritable bowel syndrome (often just called “IBS”) with constipation in adult patients.
Croatian: Koristi se za liječenje simptoma umjerenog do teškog oblika sindroma iritabilnog crijeva (koji se često naziva „IBS“) sa zatvorom u odraslih bolesnika.
English: If you stop taking Constella
Croatian: Ako prestanete uzimati Constellu
English: If you forget to take Constella
Croatian: Ako ste zaboravili uzeti Constellu
English: Clinically meaningful response in overall IBS-QoL (> 14 points difference) was achieved in 54% of linaclotide treated patients vs. 39% in placebo treated patients.
Croatian: Klinički značajan odgovor u odnosu na cjelovit IBS-QoL (> 14 bodova razlike) je ostvaren u 54% bolesnika liječenih linaklotidom naspram 39% bolesnika liječenih placebom.
English: What Constella contains - The active substance is linaclotide.
Croatian: Što Constella sadrži - Djelatna tvar je linaklotid.
English: Other common adverse reactions (>1%) were abdominal pain, abdominal distension and flatulence.
Croatian: Ostale česte nuspojave (>1%) su bol u abdomenu, distenzija abdomena i flatulencija.
English: Capsule content: microcrystalline cellulose, hypromellose, calcium chloride dihydrate and leucine.
Croatian: Sadržaj kapsule: mikrokristalična celuloza, hipromeloza, kalcijev klorid dihidrat i leucin.
English: Other signs and symptoms of IBS-C including bloating, complete spontaneous bowel movement (CSBM) frequency, straining, stool consistency, were improved in linaclotide treated patients vs. placebo (p<0.0001) as shown in the following table.
Croatian: Ostali znakovi i simptomi IBS-C-a uključujući nadutost, učestalost potpunog spontanog pražnjenja crijeva, naprezanje i konzistenciju stolice su se poboljšali u bolesnika liječenih linaklotidom u usporedbi s placebom (p< 0,0001) kao što je prikazano u sljedećoj tablici.
English: Following single doses of up to 966 micrograms and multiple doses up to 290 micrograms of linaclotide, there were no detectable plasma levels of parent compound or the active metabolite (des-tyrosine).
Croatian: Nakon primjene jednokratnih doza do 966 mikrograma i višestrukih doza do 290 mikrograma linaklotida, nisu utvrđene razine ishodišnog lijeka ili aktivnog metabolita (des-tirozin) koje bi bilo moguće detektirati u plazmi.
English: Activation of GC-C results in an increase in concentrations of cyclic guanosine monophosphate (cGMP), both extracellularly and intracellularly.
Croatian: Aktiviranje GC-C rezultira povećanjem koncentracija cikličkog gvanozin-monofosfata (cGMP), kako izvanstanično tako i unutarstanično.
English: White to off-white-orange opaque capsule (18 mm x 6.35 mm) marked “290” with grey ink.
Croatian: Neprozirna kapsula bijele do bjelkasto-narančaste boje (18 mm x 6,35 mm) s oznakom „290“ otisnutom sivom tintom.
English: IBS is a common gut disorder.
Croatian: IBS je čest poremećaj crijeva.
English: Pregnancy and breast-feeding Limited information is available on the effects of Constella in pregnant and breast-feeding women.
Croatian: Na raspolaganju su ograničene informacije o utjecajima Constelle u trudnica i dojilja.
English: Linaclotide is rarely detectable in plasma following administration of the recommended clinical doses and in vitro studies have shown that linaclotide is neither a substrate nor an inhibitor/inducer of the cytochrome P450 enzyme system and does not interact with a series of common efflux and uptake transporters (see section 5.2).
Croatian: Linaklotid se rijetko otkriva u plazmi nakon davanja preporučenih kliničkih doza, a in vitro ispitivanja su pokazala da linaklotid nije ni supstrat, niti inhibitor/induktor enzimskog sustava citokroma P450 te da nema interakcija s nizom uobičajenih transportera izbacivanja i unosa u stanici (vidjeti dio 5.2).
English: Constella acts locally in your gut, helping you to feel less pain and less bloated, and to restore the normal functioning of your bowels.
Croatian: Constella djeluje lokalno u Vašim crijevima, pomažući u smanjenju osjećaja boli i nadutosti i ponovno uspostavlja normalni rad crijeva.
English: Linaclotide is a Guanylate Cyclase-C receptor agonist (GCCA) with visceral analgesic and secretory activities.
Croatian: Linaklotid je agonist receptora gvanilat ciklaze-C (GCCA) s visceralnom analgetičkom i sekretornom aktivnošću.
English: Both linaclotide and des-tyrosine active metabolite are reduced and enzymatically proteolyzed within the gastrointestinal tract to smaller peptides and naturally occurring amino acids.
Croatian: Linaklotid i aktivni metabolit des-tirozin se reduciraju i enzimatski proteoliziraju unutar gastrointestinalnog trakta na manje peptide i aminokiseline koje se prirodno pojavljuju.
English: Should prolonged (e.g. more than 1 week) or severe diarrhoea occur, medical advice should be sought and temporary discontinuation of linaclotide until diarrhoea episode is resolved may be considered.
Croatian: Ako se dogode slučajevi produljenog (npr. dulje od tjedan dana) ili teškog proljeva, mora se potražiti savjet liječnika i razmotriti privremeni prekid uzimanja linaklotida za vrijeme trajanja proljeva.
English: In those patients in whom diarrhoea led to discontinuation, it resolved after a few days of discontinuing treatment.
Croatian: U bolesnika koji su prekinuli liječenje radi proljeva, nekoliko dana nakon prekida liječenja proljev je prestao.
English: • low level of potassium in your blood
Croatian: • niska razina kalija u krvi
English: If you experience severe or prolonged diarrhoea (passing of frequent watery stools for 7 days or more), stop taking Constella and contact your doctor (see section 4).
Croatian: Ako imate teški ili produljeni proljev (česta vodenasta stolica u trajanju od 7 dana ili dulje), molimo prekinite primjenu Constelle i kontaktirajte Vašeg liječnika (vidjeti dio 4).
English: Intracellular cGMP causes secretion of chloride and bicarbonate into the intestinal lumen, through activation of the cystic fibrosis transmembrane conductance regulator (CFTR), which results in increased intestinal fluid and accelerated transit.
Croatian: Unutarstanični cGMP uzrokuje lučenje klorida i bikarbonata u lumen crijeva aktivacijom transmembranskog regulatora provodljivosti u cističnoj fibrozi (CFTR), što rezultira povećanjem intestinalne tekućine i ubrzanim prolazom.
English: Talk to your doctor if you suffer from inflammatory diseases of the guts such as Crohn's disease or ulcerative colitis as Constella is not recommended in these patients.
Croatian: Obratite se svom liječniku ako bolujete od upalnih bolesti crijeva kao što su Crohnova bolest ili ulcerozni kolitis, budući da primjena Constelle nije preporučena u tih bolesnika.
English: In general, linaclotide is minimally detectable in plasma following therapeutic oral doses and therefore standard pharmacokinetic parameters cannot be calculated.
Croatian: Općenito, linaklotid se u plazmi detektira u minimalnim količinama pri oralnim terapijskim dozama te se prema tome standardni farmakokinetički parametri ne mogu izmjeriti.
English: The efficacy of linaclotide was established in two randomised, double-blind, placebo-controlled Phase 3 clinical studies in patients with IBS-C.
Croatian: Djelotvornost linaklotida je utvrđena u dva randomizirana, dvostruko slijepa, placebom kontrolirana klinička ispitivanja faze III u bolesnika sa sindromom iritabilnih crijeva s konstipacijom (IBS-C).
English: Extracellular cGMP decreases pain-fiber activity, resulting in reduced visceral pain in animal models.
Croatian: Izvanstanični cGMP smanjuje aktivnost vlakana osjetljivih na bol te rezultira smanjenjem visceralne boli u životinjskih modela.
English: Do not store above 30C Keep the bottle tightly closed in order to protect from moisture
Croatian: POSEBNE MJERE ČUVANJA Ne čuvati na temperaturi iznad 30°C Bocu čuvati čvrsto zatvorenu radi zaštite od vlage
English: When 2,897 micrograms was administered on day 8, following a 7-day course of 290 micrograms/day, linaclotide was detectable in only 2 of 18 subjects at concentrations just above the lower limit of quantification of 0.2 ng/ml (concentrations ranged from 0.212 to 0.735 ng/ml).
Croatian: Kad je 2897 mikrograma primijenjeno 8. dan, nakon sedmodnevne primjene 290 mikrograma dnevno, linaklotid je otkriven u samo 2 od 18 ispitanika u koncentracijama tek malo iznad donje granice kvantifikacije od 0,2 ng/ml (koncentracije su se kretale od 0,212 do 0,735 ng/ml).
English: During the 2-weeks pre-treatment baseline period, patients had a mean abdominal pain score of 5.6 (0-10 scale) with 2.2% of abdominal pain-free days, a mean bloating score of 6.6 (0-10 scale), and an average of 1.8 spontaneous bowel movements (SBM)/week.
Croatian: Za vrijeme 2 tjedna početnog razdoblja prije liječenja, bolesnici su imali prosječan intenzitet boli u abdomenu od 5,6 (na ljestvici 0-10) s 2,2% dana bez boli u abdomenu, dok je prosječan intenzitet nadutosti bio 6,6 (na ljestvici 0-10), a spontano pražnjenje crijeva iznosilo je prosječno 1,8 puta tjedno.
English: In a cross-over food interaction study, 18 healthy subjects were administered Constella 290 micrograms for 7 days both in the fasting and fed state.
Croatian: U ukriženom ispitivanju interakcije hrane, 18 zdravih ispitanika je primalo Constella 290 mikrograma tijekom 7 dana natašte i nakon obroka.
English: Flatulence Abdominal distension
Croatian: Bol u abdomenu Flatulencija Distenzija abdomena
English: The potential inhibitory activity of linaclotide and its active primary metabolite MM-419447 on the human efflux transporters BCRP, MRP2, MRP3, and MRP4 and the human uptake transporters OATP1B1, OATP1B3, OATP2B1, PEPT1 and OCTN1 was investigated in vitro.
Croatian: Potencijalna inhibitorska aktivnost linaklotida i njegovog aktivnog primarnog metabolita MM-419447 na transportere izbacivanja u ljudi BCRP, MRP2, MRP3 i MRP4 i transportere unosa u ljudi OATP1B1,
English: A food interaction clinical study in healthy subjects showed that linaclotide was not detectable in plasma either in fed or in fasted conditions at the therapeutic doses.
Croatian: Kliničko ispitivanje interakcije s hranom na zdravim ispitanicima pokazalo je da se linaklotid u terapijskim dozama ne može otkriti u plazmi niti nakon obroka niti natašte.
English: An IBS degree of relief responder was a patient that was considerably or completely relieved for at least 50% of the treatment period; an abdominal pain/discomfort responder was a patient that had an improvement of 30% or more for at least 50% of the treatment period.
Croatian: Kao bolesnik s odgovorom s obzirom na stupanj olakšanja IBS-a se smatrao onaj koji je značajno ili u potpunosti oslobođen boli u trajanju od najmanje 50% provedenog vremena liječenja; kod bolova/nelagode u abdomenu bolesnik s odgovorom je bio onaj koji je imao 30%-tno poboljšanje ili više u trajanju od najmanje 50% provedenog vremena liječenja.
English: Bloating (11-point NRS)
Croatian: Nadutost (numerička ljestvica od 11 bodova)
English: Constella is indicated for the symptomatic treatment of moderate to severe irritable bowel syndrome with constipation (IBS-C) in adults.
Croatian: Constella je indicirana za simptomatsko liječenje umjerenog do teškog oblika sindroma iritabilnog crijeva s konstipacijom (IBS-C) u odraslih osoba.
English: Of these patients, 892 patients received linaclotide at the recommended dose of 290 micrograms per day.
Croatian: 892 bolesnika od 1166 je primilo linaklotid u preporučenoj dozi od 290 mikrograma dnevno.