FrancophonIA/ELRC3.0 huggingface dataset:
English: Thereafter your child will be switched to a twice daily dosing schedule and your child's doctor will decide the right dose based either on your child's weight or body surface area.
Croatian: Nakon toga će se Vaše dijete prebaciti na raspored doziranja dvaput dnevno te će liječnik Vašeg djeteta odlučiti o pravilnoj dozi na osnovi težine ili površine tijela Vašeg djeteta.
English: The first 18 weeks of treatment is a critical period which requires close monitoring.
Croatian: Prvih 18 tjedana liječenja predstavlja kritično razdoblje koje zahtijeva pomno praćenje.
English: Do not chew your prolonged-release tablets.
Croatian: Ne žvačite tablete s produljenim oslobađanjem.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Croatian: Bolesnici s kroničnim hepatitisom B ili C koji se liječe kombiniranom antiretrovirusnom terapijom su pod povećanim rizikom od teških i potencijalno fatalnih jetrenih nuspojava.
English: Renal impairment (mild, moderate and severe) resulted in no significant change in the pharmacokinetics of nevirapine.
Croatian: Oštećenje bubrega (blago, umjereno i teško) nije rezultiralo značajnim promjenama u pogledu farmakokinetike nevirapina.
English: An increased risk was observed in men with detectable HIV-1 RNA in plasma and CD4 counts > 400 cells/mm
Croatian: Povećan rizik primijećen je u muškaraca s detektabilnom HIV-1 RNK u plazmi i brojem CD4 >400 stanica/mm
English: Taking Viramune with food and drink There are no restrictions on taking Viramune with food and drink.
Croatian: Ne postoje ograničenja u uzimanju Viramunea s hranom i pićem.
English: Viramune 50 mg/5 ml Oral suspension and Viramune 400 mg and 100 mg prolonged-release tablets
Croatian: Viramune 50 mg/5 ml oralna suspenzija i Viramune 400 mg i 100 mg tablete s produljenim oslobađanjem
English: Appropriate doses for hormonal contraceptives (oral or other forms of application) other than DMPA in combination with Viramune have not been established with respect to safety and efficacy.
Croatian: Odgovarajuće doze hormonskih kontraceptiva (oralni ili drugi oblici primjene), osim DMPA, u kombinaciji s Viramuneom nisu utvrđene s obzirom na sigurnost i djelotvornost.
English: The safety and efficacy of Viramune has not been established in patients with significant underlying liver disorders.
Croatian: Sigurnost i djelotvornost lijeka Viramune nije ustanovljena u bolesnika s već značajnim podležećim poremećajima jetre.
English: Percent change n=419
Croatian: Postotak promjene n=419
English: Women appear to be at higher risk than men of developing rash, whether receiving nevirapine or non-nevirapine containing therapy.
Croatian: Pokazalo se da su žene rizičnija skupina od muškaraca za razvoj osipa, bez obzira primaju li terapiju nevirapinom ili primaju terapiju koja ne sadrži nevirapin.
English: For children, increase of the dose of lopinavir/ritonavir to 300/75 mg/m twice daily with food should be considered when used in combination with Viramune, particularly for patients in whom reduced susceptibility to lopinavir/ritonavir is suspected.
Croatian: Za djecu, povišenje doze lopinavir/ritonavira na 300/75 mg/m dvaput dnevno s hranom treba razmotriti kada se primjenjuje u kombinaciji s Viramuneom osobito za bolesnike u kojih se sumnja na smanjenu podložnost na lopinavir/ritonavir.
English: EXP Use within 2 months after 1
Croatian: EXP Upotrijebiti unutar 2 mjeseca nakon prvog otvaranja
English: If you forget to take Viramune
Croatian: Ako ste zaboravili uzeti Viramune
English: Nevirapine pharmacokinetics in HIV-1 infected adults does not appear to change with age (range 19-68 years) or race (Black, Hispanic, or Caucasian).
Croatian: Smatra se da se farmakokinetika nevirapina u odraslih osoba s HIV-1 infekcijom ne mijenja ovisno o dobi (između 19-68 godina) ili rasi (crnci, Hispanci ili bijelci).
English: In such patients haematological parameters should be carefully monitored.
Croatian: Kod takvih bolesnika potrebno je pažljivo praćenje hematoloških parametara.
English: You should stop breast-feeding if you are taking Viramune.
Croatian: Potrebno je prekinuti dojenje ako uzimate Viramune.
English: All of these effects subsided following discontinuation of nevirapine.
Croatian: Svi ovi učinci povukli su se nakon prekida terapije nevirapinom.
English: All patients less than 16 years of age receiving Viramune oral suspension should have their weight or BSA checked frequently to assess if dose adjustments are necessary.
Croatian: Svi bolesnici ispod 16 godina starosti koji primaju Viramune oralnu suspenziju moraju redovito kontrolirati tjelesnu težinu ili BSA radi ocjene potrebe za prilagođavanjem doze.
English: All paediatric patients should have their weight or BSA checked frequently to assess if dose adjustments are necessary.
Croatian: Svi pedijatrijski bolesnici moraju redovito kontrolirati težinu ili BSA radi ocjene potrebe za prilagođavanjem doze.
English: Medicinal products by therapeutic areas
Croatian: Lijekovi prema terapijskim područjima
English: If rash occurs and you also feel sick, you must stop treatment and visit your doctor immediately.
Croatian: Ako se pojavi osip i osjećate se bolesnim, morate prekinuti liječenje i odmah se javiti liječniku.
English: The primary endpoint, treatment failure, was defined as less than 1 log10 decline in plasma HIV-1 RNA in the first 12 weeks, or two consecutive measurements of more than 50 copies/ ml from week 24 onwards, or disease progression.
Croatian: Primarni ishod, terapijski neuspjeh, definiran je kao sniženje plazmatske razine HIV-1 RNK tijekom prvih 12 tjedana ili nalaza dva uzastopna mjerenja koja pokazuju više od 50 kopija/ml nakon 24 tjedana liječenja ili progresija bolesti.
English: This should be taken into account in patients with diabetes mellitus.
Croatian: O tome treba voditi računa u kod bolesnika sa šećernom bolešću.
English: Measure the exact dose using the measuring syringe and adapter supplied as follows:
Croatian: Odmjerite točno doziranje, uz pomoć dozirne štrcaljke i nastavka koji su priloženi, na sljedeći način:
English: For patients 8 years and older the recommended dose is 4 mg/kg once daily for two weeks followed by 4 mg/kg twice daily thereafter.
Croatian: Za bolesnike u dobi 8 i više godina starosti preporučena doza je 4 mg/kg jednom dnevno tijekom dva tjedna iza čega slijedi 4 mg/kg dvaput dnevno.
English: Cross-resistance between nevirapine and either HIV protease inhibitors, HIV integrase inhibitors or HIV entry inhibitors is unlikely because the enzyme targets involved are different.
Croatian: Ukrižena rezistencija na nevirapin i inhibitore proteaza HIV-a, inhibitore integraza HIV-a ili inhibitore ulaska HIV-a nije vjerojatna budući da ti lijekovi djeluju na različite enzime.
English: A clinically not relevant increase in the apparent clearance of nevirapine (by 9%) compared to historical data was reported.
Croatian: Prijavljeno je klinički beznačajno povećanje vidljivog klirensa nevirapina za 9% u usporedbi s povijesnom kontrolom.
English: Patients who interrupt nevirapine dosing for more than 7 days should restart the recommended dosing regimen using the two week lead-in period.
Croatian: Bolesnici koji prekinu doziranje nevirapina dulje od 7 dana moraju ponovo početi s preporučenim režimom doziranja uz dvotjedno uvodno razdoblje.
English: Weight Range (kg) for patients  8 years of age
Croatian: Raspon težine (kg) za bolesnike  8 godina
English: Triglycerides (mg/dL) * Percent change is the median of within-patient changes from baseline for patients with both baseline and week 48 values and is not a simple difference of the baseline and week 48 mean values, respectively.
Croatian: Trigliceridi (mg/dl) * Promjena u postotku je medijan promjena među bolesnicima u odnosu na početne vrijednosti za bolesnike za koje postoje i početne vrijednosti i vrijednosti nakon 48 tjedana, te nije jednostavna razlika srednjih vrijednosti između početnih vrijednosti i nakon 48 tjedana.
English: If patients experience fatigue they should avoid potentially hazardous tasks such as driving or operating machinery.
Croatian: Ako bolesnik osjeti umor mora izbjegavati potencijalno opasne radnje kao što su upravljanje vozilima i rad sa strojevima.
English: The interaction between nevirapine and the antithrombotic agent warfarin is complex, with the potential for both increases and decreases in coagulation time when used concomitantly.
Croatian: Interakcije između nevirapina i antitrombotika varfarina su kompleksne, s potencijalom za povećanje i za smanjenje vremena koagulacije, kada se primjenjuju istodobno.
English: Viramune oral suspension is in a liquid suspension form and should only be taken by mouth.
Croatian: Viramune oralna suspenzija je tekući oblik suspenzije te se primjenuje samo kroz usta.
English: Clinical hepatitis reported as clinical adverse event occurred in 10 (2.6 %) and 2 (0.5 %) patients in the nevirapine twice daily and efavirenz groups respectively.
Croatian: Klinički hepatitis prijavljen kao klinička nuspojava dogodio se u 10 (2,6%) bolesnika na nevirapinu dvaput dnevno i u 2 (0,5%) bolesnika na efavirenzu.
English: Biotransformation and elimination: In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 (oxidative) metabolism to several hydroxylated metabolites.
Croatian: Biotransformacija i eliminacija: In vivo i in vitro ispitivanja u ljudi s pripravcima humanih jetrenih mikrosoma pokazuju da se nevirapin opsežno (oksidativno) biotransformira posredstvom metabolizma citokroma P450 u nekoliko hidroksiliranih metabolita.
English: Nevirapine Cmax  1.24 compared to historical controls.
Croatian: Nevirapin Cmax  1,24 u usporedbi s povijesnom kontrolom.
English: Concomitant prednisone use (40 mg/day for the first 14 days of Viramune administration) has been shown not to decrease the incidence of nevirapine-associated rash, and may be associated with an increase in incidence and severity of rash during the first 6 weeks of nevirapine therapy.
Croatian: Istodobna primjena prednizona (40 mg/dan prvih 14 dana primjene Viramunea) nije smanjila incidenciju osipa povezanog s nevirapinom, a može biti povezana s povećanjem incidencije i težine osipa tijekom prvih 6 tjedana terapije nevirapinom.
English: The incidence of symptomatic hepatic events during the Viramune immediate-release lead-in phase was 0.5 %.
Croatian: Incidencija simptomatskih jetrenih događaja tijekom uvodnog razdoblja Viramunea s trenutnim oslobađanjem bila je 0,5 %.
English: By weight the recommended oral dose for paediatric patients up to 8 years of age is 4 mg/kg once daily for two weeks followed by 7 mg/kg twice daily thereafter.
Croatian: Prema težini preporučena oralna doza za pedijatrijske bolesnike do 8 godina starosti je 4 mg/kg jednom dnevno tijekom dva tjedna iza čega slijedi 7 mg/kg dvaput dnevno.
English: Severe and life-threatening skin reactions, including fatal cases, have occurred in patients treated with nevirapine mainly during the first 6 weeks of therapy.
Croatian: Teške i po život opasne kožne reakcije, uključujući smrtne ishode, dogodile su se u bolesnika liječenih nevirapinom, uglavnom tijekom prvih 6 tjedana terapije.
English: Itraconazole AUC  0.39 Itraconazole Cmin  0.13
Croatian: Itrakonazol AUC  0,39 Itrakonazol Cmin  0,13
English: Anaphylactic reaction was identified through post-marketing surveillance but not observed in randomised, controlled clinical studies.
Croatian: Anafilaktičke reakcije identificirane su u postmarketinškom praćenju, ali nisu opažene u randomiziranim, kontroliranim kliničkim ispitivanjima.
English: * Includes patients who received at least one dose of blinded medicinal product after randomisation.
Croatian: * Uključuje bolesnike koji su primili najmanje jednu dozu lijeka “naslijepo” nakon randomizacije.
English: However the risk continues past this period and monitoring should continue at frequent intervals throughout treatment.
Croatian: Međutim, rizik se nastavlja nakon ovog razdoblja te je potrebno nastaviti praćenje u čestim intervalima tijekom liječenja.
English: Severe or lifethreatening rash considered related to nevirapine treatment occurred in 1.1 % of patients during the lead-in phase with Viramune immediate-release.
Croatian: Teški ili po život opasan osip koji se smatrao povezanim s liječenjem nevirapinom pojavio se kod 1,1 % bolesnika tijekom uvodnog razdoblja uz Viramune s trenutnim oslobađanjem.
English: Combination therapy with nevirapine is not a curative treatment of patients infected with HIV-1; patients may continue to experience illnesses associated with advanced HIV-1 infection, including opportunistic infections.
Croatian: Kombinirana terapija nevirapinom u bolesnika inficiranih HIV-1 nije kurativna; bolesnici i dalje mogu osjećati smetnje povezane s uznapredovalom HIV-1 infekcijom, uključujući oportunističke infekcije.
English: The following data were generated using the Viramune immediate-release tablets but are expected to apply to all dosage forms.
Croatian: Sljedeći podaci dobiveni su iż primjene Viramune tableta s trenutnim oslobađanjem, ali smatraju se primjenjivima na sve oblike doziranja.
English: An oral suspension dosage form, which can be dosed according to body weight or body surface area, is available for children in this age group weighing less than 50 kg or whose body surface area is below 1.25 m2 (please refer to the
Croatian: Doziranje u obliku oralne suspenzije, koja se može dozirati prema tjelesnoj težini ili tjelesnoj površini, namijenjen je djeci u toj dobnoj skupini čija je tjelesna težina manja od 50 kg ili čija je tjelesna površina manja od 1,25 m2 (molimo,
English: 3, who have a detectable plasma HIV-1 RNA unless the benefit outweighs the risk.
Croatian: 3 koji imaju detektibilan HIV 1RNK u plazmi, osim ako mogući pozitivni učinci ne nadilaze rizike.
English: These outcomes include all patients who were randomised after the 14 day lead-in with Viramune immediate-release and received at least one dose of blinded medicinal product.
Croatian: Ovi ishodi uključuju sve bolesnike koji su bili randomizirani nakon 14 dana uvodnog razdoblja uz Viramune s trenutnim oslobađanjem te su primili najmanje jednu dozu lijeka “naslijepo”.
English: Significantly fewer patients in the abacavir group (9 patients, or 6 %) than in the nevirapine group (26 patients, or 17 %) or the efavirenz group (27 patients, or 17 %) discontinued the medicinal product because of adverse events.
Croatian: Značajno manje bolesnika u skupini na abakaviru (9 bolesnika ili 6%) nego u skupini na nevirapinu (26 bolesnika ili 17%) ili skupini na efavirenzu (27 bolesnika ili 17%) prekinulo je uzimanje lijeka zbog nuspojava.
English: Nevirapine Cmax  0.50 compared to historical controls.
Croatian: Nevirapin Cmax  0,50 u usporedbi s povijesnom kontrolom.
English: Patients developing signs or symptoms of hepatitis, severe skin reaction or hypersensitivity reactions must discontinue nevirapine and seek medical evaluation immediately.
Croatian: Bolesnici u kojih se razvijaju znaci ili simptomi hepatitisa, teške kožne reakcije i reakcije preosjetljivosti moraju prekinuti primjenu nevirapina i odmah potražiti liječničku pomoć.
English: YOU SHOULD DISCONTINUE TAKING VIRAMUNE AND YOU MUST CONTACT your doctor IMMEDIATELY as such reactions can be potentially life-threatening or lead to death.
Croatian: I ODMAH SE JAVITI LIJEČNIKU jer takve reakcije mogu biti potencijalno opasne po život te dovesti do smrti.
English: Nevirapine readily crosses the placenta and is found in breast milk.
Croatian: Nevirapin dobro prolazi placentu i nađen je u majčinom mlijeku.
English: Viramune prolonged-release tablets or parts of tablets may occasionally be passed and seen in the stool (faeces).
Croatian: Viramune tablete s produljenim oslobađanjem ili njihovi dijelovi mogu ponekad proći te se primijetiti u stolici (fecesu).
English: In this 48-week study no unexpected safety findings were observed in either dosing group.
Croatian: U ovom 48-tjednom ispitivanju nisu opaženi neočekivanih sigurnosnih otkrića.
English: Each 5 ml contains 50 mg of the active substance nevirapine (as hemihydrate).
Croatian: Svakih 5 ml sadrži 50 mg djelatne tvari nevirapina (u obliku hemihidrata).
English: If clinical hepatitis occurs, characterised by anorexia, nausea, vomiting, icterus AND laboratory findings (such as moderate or severe liver function test abnormalities (excluding GGT)), nevirapine must be permanently stopped.
Croatian: Ako dođe do pojave kliničkog hepatitisa karakteriziranog anoreksijom, mučninom, povraćanjem, ikterusom i poremećajima laboratorijskih nalaza (kao što su umjerene ili teške abnormalnosti u testovima jetrenih funkcija (isključujući GGT)), trajno se mora obustaviti terapija nevirapinom.
English: Shake the bottle gently.
Croatian: Lagano promućkajte bocu.
English: There is no known antidote for nevirapine overdose.
Croatian: Nije poznat antidot pri predoziranju nevirapinom.
English: Peak plasma nevirapine concentrations of 2  0.4 µg/ml (7.5 µM) were attained by 4 hours following a single 200 mg dose.
Croatian: Vršne koncentracije nevirapina u plazmi od 2 ± 0,4 µg/ml (7,5 µM) postignute su 4 sata nakon jednokratne doze od 200 mg.
English: Any inflammatory symptoms should be evaluated and treatment instituted when necessary.
Croatian: Potrebna je ocjena svih simptoma upale, a liječenje se određuje, prema potrebi.
English: Otherwise patients with CLcr  20 ml/min do not require an adjustment in nevirapine dosing.
Croatian: Inače, bolesnici s CLcr ≥20 ml/min ne zahtijevaju podešavanje doze nevirapina.
English: Asymptomatic elevations of GGT levels are the most frequent.
Croatian: Najčešća su bila asimptomatska povišenja razina GGT-a.
English: The dose must be strictly adhered to, especially the 14-days lead-in period (see section 4.2).
Croatian: Nužno je strogo se pridržavati doze, osobito tijekom 14-dnevnog uvodnog razdoblja (vidjeti dio
English: The frequencies estimated are based on pooled clinical study data for adverse reactions considered related to Viramune treatment.
Croatian: Procjena učestalosti temelji se na objedinjenim podacima iz kliničkih ispitivanja o nuspojavama za koje se smatra da su povezane s liječenjem Viramuneom.
English: In study 1100.1090, from which the majority of related adverse events (n=28) were received, patients on placebo had a higher incidence of events of granulocytopenia (3.3 %) than patients on nevirapine
Croatian: U studiji 1100.1090 iz kojeg potječe većina prijavljenih nuspojava (n=28), bolesnici na placebu imali su višu incidenciju događaja granulocitopenije (3,3%) nego belesnici na nevirapinu (2,5%).
English: Post-Exposure-Prophylaxis: Serious hepatotoxicity, including liver failure requiring transplantation, has been reported in HIV-uninfected individuals receiving multiple doses of Viramune in the setting of post-exposure-prophylaxis (PEP), an unapproved use.
Croatian: Postekspozicijska profilaksa: Teška hepatotoksičnost, uključujući zatajenje jetre koje zahtijeva transplataciju, prijavljena je u osoba koje nisu inficirane HIV-om, a koje su primale višekratne doze Viramunea u svrhu postekspozicijske profilakse (PEP), što nije odobrena indikacija primjene.
English: Due to the metabolic pathway of raltegravir no interaction is expected.
Croatian: Zbog metaboličkog puta raltegravira ne očekuju se interakcije.
English: Recommended paediatric dosing by BSA after the lead-in period BSA (m2) Viramune prolonged-release tablets dose (mg) 0.58-0.83 200 (2 x 100 mg) 0.84-1.16 300 (3 x 100 mg) 400 (1 x 400 mg)
Croatian: Preporučeno pedijatrijsko doziranje prema BSA nakon uvodnog razdoblja BSA (m2) Doza Viramune tableta s produljenim oslobađanjem (mg) 0,58-0,83 200 (2 x 100 mg) 0,84-1,16 300 (3 x 100 mg) 400 (1 x 400 mg)
English: Nevirapine belongs to a class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Croatian: Nevirapin spada u skupinu lijekova protiv HIV-a koji se nazivaju nenukleozidni inhibitori reverzne transkriptaze (NNRTI-i).
English: As mentioned in ‘Warnings and precautions', above, the most important side effects of Viramune are severe and life threatening skin reactions and serious liver damage.
Croatian: Kao što je navedeno u dijelu «Upozorenja i mjere opreza», najvažnije nuspojave Viramunea su teške i po život opasne kožne reakcije te ozbiljna oštećenja jetre.
English: Dividing a 200 mg total dose into four 50 mg doses rather than two 100 mg doses produced a 7-11 % greater overall absorption, but with comparable medicinal product release rates.
Croatian: Dijeljenje ukupne doze od 200 mg u četiri doze od 50 mg prije nego dvije doze od 100 mg dovelo je do veće ukupne apsorpcije od 7-11 %, ali uz usporedive stope oslobađanja lijeka.
English: The following adverse reactions have also been reported when nevirapine has been used in combination with other anti-retroviral agents: pancreatitis, peripheral neuropathy and thrombocytopaenia.
Croatian: Sljedeće nuspojave također su prijavljene u kombinaciji primjene nevirapina s drugim antiretrovirusnim lijekovima: pankreatitis, periferna neuropatija i trombocitopenija.
English: Overall, the exposure in children was similar to that observed in adults receiving Viramune prolonged-release in study 1100.1486.
Croatian: Ukupno izlaganje kod djece bilo je slično kao kod odraslih osoba na Viramuneu s produljenim oslobađanjem u ispitivanju 1100.1486.
English: Table 2 describes week 48 outcomes in the VERxVE study (1100.1486).
Croatian: Tablica 2 opisuje ishode nakon 48 tjedana u ispitivanju VERxVE (1100.1486).
English: Rare (may affect up to 1 in 1000 people): - inflammation of the liver (hepatitis) - decreased numbers of red blood cells (anaemia)
Croatian: Rijetko (može se javiti u do 1 na 1 000 osoba): - upala jetre (hepatitis) - smanjen broj crvenih krvnih stanica (anemija)
English: Summary of Product Characteristics of Viramune oral suspension).
Croatian: pogledajte sažetak opisa svojstava lijeka za Viramune oralnu suspenziju).
English: Viramune is also supplied as 200 mg tablets for older children and adults.
Croatian: Viramune je također dostupan u obliku tableta od 200 mg za stariju djecu i odrasle.
English: If you experience symptoms suggesting damage of the liver, such as - loss of appetite, - feeling sick (nausea), - vomiting, - yellow skin (jaundice), - abdominal pain you should discontinue taking Viramune and must contact your doctor immediately.
Croatian: Ako imate simptome koji ukazuju na oštećenje jetre, kao što su - gubitak apetita, - mučnina, - povraćanje, - žuta koža (žutica), - bol u trbuhu prekinite uzimanje Viramunea i odmah se javite liječniku.
English: Viramune is also available in liquid form as an oral suspension.
Croatian: Viramune je također dostupan u tekućem obliku kao oralna suspenzija.
English: A reduction in white blood cells (granulocytopenia) can occur, which is more common in children.
Croatian: Može doći do smanjenja broja bijelih krvnih stanica (granulocitopenija), što je češće u djece.
English: The relative bioavailability of nevirapine when dosed as one 400 mg Viramune prolonged-release tablet, relative to two 200 mg Viramune immediaterelease tablets, was approximately 75 %.
Croatian: Relativna bioraspoloživost nevirapina pri dozi od jedne 400 mg Viramune tablete s produljenim oslobađanjem, u odnosu na dvije 200 mg Viramune tablete s trenutnim oslobađanjem, bila je oko 75 %.
English: Virologic responder (HIV-1 RNA <50 copies/ml)
Croatian: Osobe s virološkim odgovorom (HIV-1 RNK <50 kopija/ml)
English: Of the patients with grade 3 or 4 liver-associated laboratory toxicity, the proportions coinfected with hepatitis B or hepatitis C virus were 6.7 % and 20.0 % in the nevirapine twice daily group, 5.6 % and 11.1 % in the efavirenz group.
Croatian: Među bolesnicima koji su imali laboratorijske nalaze oštećenja jetre stupnja 3 ili 4, udio onih koji su bili istodobno inficirani s virusom hepatitisa B ili C bio je 6,7% odnosno 20,0% u skupini koja je dobivala nevirapin dvaput dnevno, odnosno 5,6% i 11,1% u skupini koja je dobivala efavirenz.