FrancophonIA/ELRC3.0 huggingface dataset:
English: Sodium hydroxide (for pH-adjustment) Water for injections
Slovenian: 6.1 Seznam pomožnih snovi benzalkonijev klorid manitol borova kislina natrijev hidroksid (za uravnavanje pH) voda za injekcije
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Rhokiinsa 200 micrograms/ml eye drops netarsudil
Slovenian: IME ZDRAVILA IN POT(I) UPORABE Rhokiinsa 200 mikrogramov/ml kapljice za oko netarsudil okularna uporaba
English: What you need to know before you use Rhokiinsa Do not use Rhokiinsa: - if you are allergic to netarsudil or any of the other ingredients of this medicine (listed in section
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Rhokiinsa Ne uporabljajte zdravila Rhokiinsa:
English: PHARMACEUTICAL FORM AND CONTENTS Eye drops, solution
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA kapljice za oko, raztopina 1 x 2,5 ml
English: Rhokiinsa is supplied sterile in opaque white low density polyethylene bottles (2.5 ml fill in a 4 ml container) and tips with white polypropylene caps and anti-tamper seals.
Slovenian: (polnjenje 2,5 ml v 4-ml vsebniku) s kapalno konico z belim polipropilenskim pokrovčkom in tesnilom za zaščito pred poseganjem v zdravilo.
English: If you get any side effects, talk to your doctor, or pharmacist.
Slovenian: Če opazite katerega koli izmed neželenih učinkov, se posvetujte z zdravnikom ali farmacevtom.
English: Netarsudil and its active metabolite AR-13503 was found to have a possible phototoxic potential in a modified 3T3 NRU-PT in vitro assay, where the wavelength was extended to include UVB light.
Slovenian: Z modificiranim testom 3T3 NRU-PT in vitro, pri katerem so valovne dolžine razširili in vanje vključili tudi UVB-svetlobo, so ugotovili, da imata netarsudil in njegov aktivni presnovek AR-13503
English: How to store Rhokiinsa
Slovenian: Shranjevanje zdravila Rhokiinsa
English: Common headache Uncommon dizziness,
Slovenian: Pogosti krvavitev v veznico, zamegljen vid,
English: Boric acid
Slovenian: diabetična retinopatija,
English: Common conjunctival haemorrhage, vision blurred, lacrimation increased, erythema of eyelid, eye pruritis, eye irritation, visual acuity reduced, eyelid oedema, punctate keratitis, conjunctival oedema, foreign body sensation in eyes, conjunctivitis, conjunctivitis allergic, photophobia, eyelid pruritus, eye pain, corneal opacity, dry eye, eye discharge,
Slovenian: občutek tujka na mestu vkapanja, draženje na mestu vkapanja, steklaste oči, utrujenost, izsušenost na mestu vkapanja, edem na mestu vkapanja, parestezija na mestu vkapanja, obarvanost veznice,
English: You may find that your vision is blurred or abnormal just after using Rhokiinsa.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Morda boste tik po uporabi zdravila Rhokiinsa ugotovili, da imate zamegljen ali nenormalen vid. Ne vozite in ne upravljajte strojev, dokler ti simptomi ne izginejo.
English: The following adverse reactions have been reported with netarsudil, dosed once daily.
Slovenian: Pri netarsudilu, ki so ga dajali enkrat na dan, so poročali o naslednjih neželenih učinkih.
English: Uncommon dermatitis allergic, dermatitis contact, lichenification, petechiae Musculoskeletal and connective tissue disorders Uncommon polychondritis Injury, poisoning and procedural complications Uncommon excoriation 1 See Description of selected adverse reactions for further information
Slovenian: Občasni alergijski dermatitis, kontaktni dermatitis, lihenifikacija, petehije
English: Nervous system disorders
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva
English: Rinse your eye with warm water.
Slovenian: Če ste uporabili večji odmerek zdravila Rhokiinsa, kot bi smeli Oko si sperite s toplo vodo.
English: Respiratory, thoracic and mediastinal disorders Uncommon nasal discomfort, rhinalgia
Slovenian: motnja veke, disfunkcija Meibomovih žlez, pigmentacija roženice, diplopija, ektropij,
English: Date of first authorisation: 28 February 2002 Date of latest renewal: 20 November 2006
Slovenian: Datum prve odobritve: 28. februar 2002 Datum zadnjega podaljšanja: 20. november 2006
English: Therefore it should not be used in this age group.
Slovenian: Zato se ga pri tej starostni skupini ne sme uporabljati.
English: County Kerry Ireland
Slovenian: County Kerry Irska
English: Data from six major trials are presented here.
Slovenian: Tukaj so prikazani podatki iz šestih velikih raziskav.
English: Your doctor will decide which strength is best for you.
Slovenian: Zdravnik bo odločil, katera jakost je primerna za vas.
English: Improvement is usually seen within one week.
Slovenian: Izboljšanje je ponavadi vidno v enem tednu.
English: These may include monitoring of vital signs and observation of clinical status.
Slovenian: To lahko vključuje nadziranje vitalnih znakov in opazovanje kliničnega stanja.
English: The average total body clearance is approximately 2.25 l/h.
Slovenian: Povprečni celotni telesni očistek je približno 2,25 l/uro.
English: The results in the control group were similar.
Slovenian: Izsledki v kontrolni skupini so bili primerljivi.
English: Treatment duration was for up to three weeks.
Slovenian: Zdravljenje je trajalo do tri tedne.
English: If you forget to apply the ointment at the scheduled time, do it as soon as you remember and then continue as before.
Slovenian: Če mazilo pozabite nanesti ob predvidenem času, ga nanesite, čim se spomnite, in nato nadaljujte kot prej.
English: Specific studies have not been conducted in older people.
Slovenian: Posebne študije pri starejših ljudeh niso bile izvedene.
English: In addition, ask your doctor for advice on other appropriate sun protection methods.
Slovenian: Poleg tega zdravnika prosite za nasvet o drugih primernih načinih za zaščito pred soncem.
English: • increased skin sensitivity (especially to hot and cold)
Slovenian: • zvečana občutljivost kože (zlasti za vročino in mraz);
English: Children, 2-15 years
Slovenian: Otroci, 2-15 let
English: • feeling of warmth
Slovenian: • občutek toplote;
English: The primary response to vaccination was not affected.
Slovenian: Ni bilo vpliva na primarni odziv na cepljenje.
English: Rosacea* Lentigo*
Slovenian: Rozacea* Lentigo*
English: However, the clinical experience available in this patient population has not shown the necessity for any dosage adjustment.
Slovenian: Vendar pa klinične izkušnje, ki so na voljo pri tej populaciji bolnikov, ne kažejo potrebe po prilagajanju odmerka.
English: If ingested, general supportive measures may be appropriate.
Slovenian: Če oseba zdravilo zaužije, utegnejo biti primerni splošni podporni ukrepi.
English: If you accidentally swallow some ointment
Slovenian: Če pomotoma zaužijete nekaj mazila
English: Do not try to induce vomiting.
Slovenian: Ne poskušajte izzvati bruhanja.
English: Other medicines, cosmetics and Protopic
Slovenian: Druga zdravila, kozmetična sredstva in zdravilo Protopic
English: It is supplied in tubes containing 10, 30 or 60 grams of ointment.
Slovenian: Pripravljeno je v tubah, ki vsebujejo po 10, 30 ali 60 gramov mazila.
English: LEO Pharma A/S Industriparken 55 2750 Ballerup Denmark
Slovenian: LEO Pharma A/S Industriparken 55 2750 Ballerup Danska
English: Reproduction toxicity
Slovenian: Reprodukcijska toksičnost
English: Adults, ≥16 years
Slovenian: Odrasli, ≥ 16 let
English: § lower values = greater improvement
Slovenian: § nižje vrednosti = večje izboljšanje
English: It is unclear whether the effect of tacrolimus is due to systemic immunosuppression or a local effect.
Slovenian: Ni jasno, ali je učinek takrolimusa posledica sistemske imunosupresije ali lokalnega učinka.
English: • Before applying Protopic after a bath or shower, be sure your skin is completely dry.
Slovenian: • Preden zdravilo Protopic nanesete po kopeli ali prhanju, se prepričajte, da je koža popolnoma suha.
English: 4.6 Fertility, Pregnancy and lactation
Slovenian: 4.6 Plodnost, nosečnost in dojenje
English: Response rate of ≥ 60%
Slovenian: Delež odziva z ≥ 60-%
English: • Avoid using the ointment inside your nose or mouth or in your eyes.
Slovenian: • Mazila ne uporabljajte v nosu, ustih ali na očeh.
English: At the first signs of recurrence (flares) of the disease symptoms, treatment should be re-initiated.
Slovenian: Ob prvih znakih recidiva (ponovnega izbruha) simptomov bolezni je treba zdravljenje začeti znova.
English: The incidence and nature of most adverse events were similar in the two treatment groups.
Slovenian: Incidenca in narava večine neželenih učinkov sta bili v obeh terapevtskih skupinah podobni.
English: Fertility There are no fertility data available.
Slovenian: Podatki o plodnosti niso na voljo.
English: Protopic treatment should begin at the first appearance of signs and symptoms.
Slovenian: Zdravljenje z zdravilom Protopic je treba začeti ob prvem pojavu znakov in simptomov.
English: Pharmacotherapeutic group: Other dermatologicals, ATC code: D11AH01
Slovenian: Farmakoterapevtska skupina: Druga dermatološka zdravila, oznaka ATC: D11AH01
English: The majority of these cases were related to infections (skin, respiratory tract, tooth) and resolved with appropriate antibiotic therapy.
Slovenian: Večina teh primerov je bila povezana z okužbami (koža, dihala, zobje) in je izginila po ustreznem antibiotičnem zdravljenju.
English: Do not use this medicine after the expiry date which is stated on the tube and carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na tubi in škatli poleg oznake »EXP«.
English: Package sizes: 10 g, 30 g and 60 g. Not all pack sizes may be marketed.
Slovenian: Velikosti pakiranj: 10 g, 30 g in 60 g. Na trgu morda ni vseh navedenih pakiranj.
English: Systemic carcinogenicity studies in mice (18 months) and rats (24 months) revealed no carcinogenic potential of tacrolimus.
Slovenian: Raziskave sistemske kancerogenosti pri miših (18 mesecev) in podganah (24 mesecev) niso odkrile kancerogenega potenciala takrolimusa.
English: • The safety of using Protopic for a long time is not known.
Slovenian: • Varnost dolgotrajne uporabe zdravila Protopic ni znana.
English: The risk for humans cannot be completely ruled out as the potential for local immunosuppression with the long-term use of tacrolimus ointment is unknown.
Slovenian: Tveganja za človeka ni mogoče povsem izključiti, ker možnost lokalne imunosupresije med dolgotrajno uporabo mazila s takrolimusom ni znana.
English: Paediatric population Frequency, type and severity of adverse reactions in children are similar to those reported in adults.
Slovenian: Pediatrična populacija Pogostnost, vrsta in stopnja resnosti neželenih učinkov pri otrocih so primerljive s tistimi, ki so opisane pri odraslih.
English: Treatment should be started twice a day for up to three weeks.
Slovenian: Zdravljenje je treba začeti z uporabo dvakrat na dan do tri tedne.
English: The response rates at month 6 were comparable to the 3-month results.
Slovenian: Deleži odziva so bili po 6 mesecih primerljivi rezultatom po 3 mesecih.
English: Frequencies are defined as very common (≥1/10), common (≥1/100 to <1/10) and uncommon (≥1/1,000 to <1/100).
Slovenian: Opredelitev pogostnosti: zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10) in občasni (≥1/1.000 do <1/100).
English: In the absence of a clear aetiology for the lymphadenopathy or in the presence of acute infectious mononucleosis, discontinuation of Protopic should be considered.
Slovenian: V odsotnosti jasne etiologije za limfadenopatijo ali v navzočnosti akutne infekcijske mononukleoze je treba pretehtati opustitev zdravila Protopic.
English: If you do not see any improvement after two weeks, see your doctor about other possible treatments.
Slovenian: Če po dveh tednih ne opazite izboljšanja, se z zdravnikom posvetujte o drugih možnih načinih zdravljenja.
English: The lowest tacrolimus blood concentration at which systemic effects can be observed is not known.
Slovenian: Najmanjša koncentracija takrolimusa v krvi, pri kateri je mogoče ugotoviti sistemske učinke, ni znana.
English: During this period all patients and control subjects (n=44) received a primary immunisation and a rechallenge with a protein-conjugate vaccine against Neisseria menigitidis serogroup C.
Slovenian: V tem obdobju so vsi bolniki in kontrolni preskušanci (n=44) prejeli primarno cepljenje ter reekspozicijo z beljakovinsko konjugiranim cepivom proti bakteriji Neisseria meningitidis seroskupine C.
English: • The effect of treatment with Protopic on the developing immune system in children, especially the young, has not been established.
Slovenian: • Učinek zdravljenja z zdravilom Protopic na razvijajoči se imunski sistem pri otrocih, posebno pri mlajših, ni ugotovljen.
English: In the presence of these infections, the balance of risks and benefits associated with Protopic use should be evaluated.
Slovenian: V primeru teh okužb je treba pretehtati tveganja in koristi uporabe zdravila Protopic.
English: Protopic ointment has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Protopic nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: If no signs of improvement are seen after two weeks of treatment, further treatment options should be considered.
Slovenian: Če po dveh tednih zdravljenja ni znakov izboljšanja, je treba preučiti druge možnosti zdravljenja.
English: As with any topical medicinal product, patients should wash their hands after application if the hands are not intended for treatment.
Slovenian: Tako kot velja za vsa lokalna zdravila, si morajo bolniki po uporabi umiti roke, razen če gre za zdravljenje sprememb na rokah.
English: If accidentally applied to these areas, the ointment should be thoroughly wiped off and/or rinsed off with water.
Slovenian: Če slučajno pride na te predele, ga je treba z njih temeljito obrisati in/ali splakniti z vodo.
English: one in adult patients (≥16 years) and one in paediatric patients (2-15 years).
Slovenian: Eno preskušanje je zajelo odrasle (≥ 16 let), eno pa pediatrične bolnike (od 2 do 15 let).
English: Protopic can be used for short-term and intermittent long-term treatment.
Slovenian: Zdravilo Protopic se lahko uporablja za kratkotrajno in dolgotrajno zdravljenje s prekinitvami.
English: Analysis of the response rate at week 5 showed equivalence between the treatment groups (hydrocortisone 98.3%, tacrolimus ointment 95.4%; 7-11 years: 100% in both arms).
Slovenian: Analiza stopnje odziva v 5. tednu ni pokazala razlik med študijskima skupinama (hidrokortizon: 98,3%, mazilo s takrolimusom: 95,4%; 7-11 let: 100% v obeh skupinah).
English: Protopic ointment should not be used in children aged below 2 years until further data are available.
Slovenian: Zdravila Protopic mazilo se ne sme uporabljati pri otrocih, mlajših od 2 let, dokler ne bodo na voljo dodatni podatki.
English: Elderly Specific studies have not been conducted in older people (see flare treatment section above).
Slovenian: Posebne študije pri starejših ljudeh niso bile izvedene (glejte zgornje poglavje o zdravljenju izbruha bolezni).
English: Oral use of tacrolimus is also not recommended to treat these skin conditions.
Slovenian: Peroralna uporaba takrolimusa se prav tako ne priporoča za zdravljenje teh kožnih bolezni.
English: Physicians should advise patients on appropriate sun protection methods, such as minimisation of the time in the sun, use of a sunscreen product and covering of the skin with appropriate clothing.
Slovenian: Zdravniki morajo bolnikom svetovati o ustreznih načinih zaščite pred soncem, npr. zmanjšanje časa, prebitega na soncu, uporabo sredstev za sončenje in zakritje kože z ustreznimi oblačili.
English: The potential for local immunosuppression (possibly resulting in infections or cutaneous malignancies) in the long term (i.e. over a period of years) is unknown (see section 5.1).
Slovenian: Potencial za lokalno imunosupresijo (ki bi morda lahko povzročila okužbe ali kožne malignome) med dolgotrajnim zdravljenjem (tj. v obdobju več let) ni znan (glejte poglavje 5.1).
English: Concomitant use of other topical preparations has not been assessed.
Slovenian: Sočasna uporaba drugih lokalnih pripravkov ni raziskana.
English: • Avoid exposing the skin to long periods of sunlight or artificial sunlight such as tanning beds.
Slovenian: • Kože ne smete dolgo časa izpostavljati sončni svetlobi ali umetni sončni svetlobi, npr. v solarijih.
English: These skin conditions may increase systemic absorption of tacrolimus.
Slovenian: Te kožne bolezni lahko zvečajo sistemsko absorpcijo takrolimusa.
English: Treatment should not be continuous on a long-term basis.
Slovenian: Dolgotrajno zdravljenje ne sme biti neprekinjeno.
English: No effect on immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity has been observed (see section 5.1).
Slovenian: Zaznali niso nobenega vpliva niti na takojšnji odziv na cepljenje in na izgrajevanje imunskega spomina niti na humoralno in celično imunost (glejte poglavje 5.1).
English: In a subanalysis of a pooled population of patients with moderate to severe atopic dermatitis these differences remained statistically significant (Table 4).
Slovenian: V subanalizi skupne populacije bolnikov z zmernim do hudim atopičnim dermatitisom so te razlike ostale statistično značilne (preglednica 4).
English: Protopic ointment should not be used during pregnancy unless clearly necessary.
Slovenian: Zdravila Protopic mazilo ne smete uporabljati med nosečnostjo, razen če je nujno potrebno.
English: If you spend time outdoors after applying Protopic, use a sunscreen and wear loose fitting clothing that protects the skin from the sun.
Slovenian: Če greste po uporabi zdravila Protopic na prosto, uporabite sredstvo za sončenje in oblecite ohlapna oblačila, ki kožo varujejo pred soncem.
English: Ophthalmic Herpes Infection*
Slovenian: Očesna okužba z virusom herpes*
English: • If you have any skin malignancies (tumours) or if you have a weakened immune system (immuno-compromised) whatever the cause.
Slovenian: • Če imate katerokoli vrsto kožnih malignomov (tumorji), ali če imate oslabljen imunski sistem (če ste imunokompromitirani), ne glede na vzrok;
English: • If you notice any change to the appearance of your skin, please inform your physician.
Slovenian: • Če opazite kakršnekoli spremembe na koži, to povejte svojemu zdravniku.
English: The changes were caused by high systemic exposure of rodents resulting from high transdermal absorption of tacrolimus.
Slovenian: Spremembe je povzročila velika sistemska izpostavljenost glodavcev, ki je bila posledica velike transdermalne absorpcije takrolimusa.
English: Table 4: Efficacy (moderate to severe subpopulation)
Slovenian: Preglednica 4: Učinkovitost (populacija z zmerno do hudo boleznijo)
English: Median time to first DE 123 days
Slovenian: Mediana časa do prvega
English: There are no adequate data from the use of tacrolimus ointment in pregnant women.
Slovenian: Ni zadostnih podatkov o uporabi mazila s takrolimusom pri nosečnicah.
English: Via its binding to a specific cytoplasmic immunophilin (FKBP12), tacrolimus inhibits calciumdependent signal transduction pathways in T cells, thereby preventing the transcription and synthesis of IL-2, IL-3, IL-4, IL-5 and other cytokines such as GM-CSF, TNF-α and IFN-γ.
Slovenian: Z vezavo na specifični citoplazemski imunofilin (FKBP12) takrolimus zavre od kalcija odvisne poti prevajanja v celicah T ter tako prepreči transkripcijo in sintezo IL-2, IL-3, IL-4, IL-5 in drugih citokinov, npr. GM-CSF, TNF-α in IFN-γ.
English: Hypersensitivity to the active substance, macrolides in general, or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na učinkovino, na makrolide na splošno, ali katerokoli pomožno snov, navedeno v poglavju 6.1.
English: • If you are allergic to tacrolimus or any of the other ingredients of this medicine (listed in section 6) or to macrolide antibiotics (e.g. azithromycin, clarithromycin, erythromycin).
Slovenian: • Če ste alergični na takrolimus ali katero koli sestavino tega zdravila (navedeno v poglavju 6) ali na makrolidne antibiotike (npr. azitromicin, klaritromicin, eritromicin).
English: What Protopic is and what it is used for What you need to know before you use Protopic How to use Protopic
Slovenian: Kaj je zdravilo Protopic in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Protopic Kako uporabljati zdravilo Protopic
English: If you forget to use Protopic
Slovenian: Če ste pozabili uporabiti zdravilo Protopic
English: Thereafter, patients entered a double-blind disease control period (DCP) for up to 12 months.
Slovenian: Potem so bolniki vstopili v dvojno slepo obdobje obvladovanja bolezni, ki je trajalo do 12 mesecev.
English: When observed, blood concentrations exceeding 1.0 ng/ml were transient.
Slovenian: V primerih, ko so zabeležili koncentracijo v krvi prek 1,0 ng/ml, je bila prehodna.
English: The efficacy and safety of Protopic was assessed in more than 18,500 patients treated with tacrolimus ointment in Phase I to Phase III clinical trials.
Slovenian: Učinkovitost in varnost zdravila Protopic so ocenili pri več kot 18.500 bolnikih, zdravljenih z mazilom s takrolimusom v kliničnih raziskavah od I. do III. faze.
English: An interaction study with protein-conjugated vaccine against Neisseria menigitidis serogroup C has been investigated in children aged 2-11 years.
Slovenian: Beljakovinsko konjugirano cepivo proti bakteriji Neisseria meningitidis seroskupine C so preučevali v študiji medsebojnega delovanja pri otrocih, starih od 2 do 11 let.
English: Embryo/foetal toxicity was observed in rats and rabbits, but only at doses that caused significant toxicity in maternal animals.
Slovenian: Pri podganah in kuncih so opažali toksičnost za zarodek/plod, vendar le v odmerkih, ki so povzročili pomembne toksične učinke pri samicah-materah.
English: Protopic with alcohol
Slovenian: Zdravilo Protopic skupaj z alkoholom
English: What Protopic is and what it is used for
Slovenian: Kaj je zdravilo Protopic in za kaj ga uporabljamo
English: Adverse reactions with suspected relationship to treatment are listed below by system organ class.
Slovenian: Neželene reakcije, za katere obstaja sum, da so povezane z zdravljenjem, so navedene spodaj po organskih sistemih.
English: In a study of maintenance treatment (twice weekly treatment) in adults and children with moderate and severe atopic dermatitis the following adverse events were noted to occur more frequently than in the control group: application site impetigo (7.7% in children) and application site infections (6.4% in children and 6.3% in adults).
Slovenian: Vzdrževalno zdravljenje V študiji vzdrževalnega zdravljenja (zdravljenje dvakrat na teden) pri odraslih in otrocih z zmernim in hudim atopičnim dermatitisom so naslednje neželene učinke zabeležili pogosteje kot v kontrolni skupini: impetigo na mestu uporabe (7,7% pri otrocih) in okužbe na mestu uporabe (6,4% pri otrocih in 6,3% pri odraslih).
English: In clinical studies approximately 50% of patients experienced some type of skin irritation adverse reaction at the site of application.
Slovenian: V kliničnih študijah je približno 50% bolnikov kot neželeni učinek na mestu uporabe doživelo draženje kože.
English: In a 24-month dermal carcinogenicity study performed in mice with 0.1% ointment, no skin tumours were observed.
Slovenian: V 24-mesečni raziskavi dermalne kancerogenosti pri miših, opravljeni z 0,1-% mazilom, niso opazili tumorjev kože.
English: The review of the child`s condition after 12 months treatment should include suspension of treatment to assess the need to continue this regimen and to evaluate the course of the disease.
Slovenian: Ponovni pregled zdravstvenega stanja po 12-mesečnem zdravljenju pri otrocih vključuje prekinitev zdravljenja, da se oceni potreba po nadaljevanju takšnega režima zdravljenja ter ovrednoti potek bolezni.
English: If symptoms reappear you should use Protopic twice daily as outlined above and arrange to see your doctor to review your treatment.
Slovenian: Če se simptomi znova pojavijo, morate uporabljati zdravilo Protopic dvakrat dnevno, kot je opisano zgoraj, in se dogovoriti za pregled pri zdravniku, ki bo znova ocenil vaše zdravljenje.