FrancophonIA/ELRC3.0 huggingface dataset:
English: It should be taken into account in pregnant or breast-feeding women and high-risk groups such as patients with liver disease or epilepsy.
Croatian: To treba uzeti u obzir i u trudnica i dojilja te visokorizičnih skupina ljudi, poput bolesnika s bolešću jetre ili epileptičara.
English: In particular, the nuclear medicine doctor in charge of the procedure may provide ways to increase the passing of urine and stools in order to help remove radioactivity from your body.
Croatian: Konkretno, liječnik specijalist nuklearne medicine koji provodi postupak može primijeniti određene metode kojima se povećava učestalost mokrenja i obavljanja nužde kako bi se ubrzalo uklanjanje radioaktivnosti iz tijela.
English: After administration of Amyvid, you should
Croatian: Nakon primjene lijeka Amyvid morate
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 14 January 2013
Croatian: Datum prvog odobrenja: 14. siječnja 2013.
English: The effective dose resulting from the administration of a 370 MBq dose for an adult weighing 70 kg is about 7 mSv.
Croatian: Efektivna doza nakon primjene doze od 370 MBq u odrasle osobe težine 70 kg iznosi približno 7 mSv.
English: The average cortical to cerebellar SUVR values in AD patients show continual substantial increases from time zero through 30 minutes post-administration, with only small changes thereafter up to 90 minutes post-injection.
Croatian: SUV-a u korteksu u odnosu na mali mozak u bolesnika s Alzheimerovom bolešću pokazuju kontinuirana značajna povećanja od nulte točke do 30. minute nakon primjene, uz tek male promjene nakon toga, do 90 minuta nakon injekcije.
English: Participating readers first evaluated a set of 96 PET scans, including 46 scans with autopsy standard of truth, using the visual qualitative read method to establish a baseline and were subsequently asked to re-evaluate the same set of scans with or without access to quantitative software information.
Croatian: Procjenitelji koji su sudjelovali u ispitivanjima najprije su ocijenili skup od 96 PET snimaka, uključujući 46 snimaka za koje je postojao obdukcijski nalaz kao standard istine, primjenom metode vizualne kvalitativne interpretacije kako bi se dobili polazni parametri, a zatim je zatraženo da ponovno ocijene isti skup snimaka uz pristup kvantitativnim informacijama generiranima softverom ili bez pristupa takvim informacijama.
English: Potential in vivo genotoxicity of florbetapir was evaluated in a rat micronucleus study.
Croatian: Potencijalna genotoksičnost florbetapira in vivo procijenjena je mikronukleusnim ispitivanjem na štakorima.
English: For the limitations of use in patients with mild cognitive impairment (MCI), see section 5.1.
Croatian: Za ograničenja primjene u bolesnika s blagim oštećenjem kognitivne funkcije (engl. mild cognitive impairment, MCI) vidjeti dio 5.1.
English: Adjunctive use of quantitative information for image interpretation The feasibility and reliability of using CE-marked quantitative software as an adjunct to clinical qualitative interpretation was investigated in two studies using three different commercially available quantitative software packages.
Croatian: Dopunska uporaba kvantitativnih informacija za interpretaciju snimaka Primjenjivost i pouzdanost uporabe softvera s oznakom CE za kvantifikaciju snimaka kao dopune kliničkoj kvalitativnoj interpretaciji ispitivale su se u dva ispitivanja uz primjenu tri različita komercijalno dostupna kvantitativna softverska paketa.
English: Before administering radiopharmaceuticals to a mother who is breast-feeding consideration should be given to the possibility of delaying the administration of radionuclide until the mother has ceased breast-feeding, and to what is the most appropriate choice of radiopharmaceuticals, bearing in mind the secretion of activity in breast milk.
Croatian: Prije primjene radiofarmaceutika u dojilja treba razmotriti mogućnost odgode primjene radionuklida do prestanka dojenja te odrediti koji je radiofarmaceutik najprikladniji s obzirom na izlučivanje aktivnosti u majčino mlijeko.
English: This medicinal product contains 10 vol % ethanol (alcohol), i.e. up to 790 mg per dose, equivalent to 20 mL beer or 8 mL wine per dose.
Croatian: Ovaj lijek sadrži 10 vol % etanola (alkohola), tj. do 790 mg po dozi, što odgovara količini od 20 ml piva ili 8 ml vina po dozi.
English: This medicine will only be handled and given to you by people who are trained and qualified to use it safely.
Croatian: Ovaj lijek će primijeniti i njime rukovati samo osobe obučene za njegovu sigurnu primjenu.
English: The solution should be inspected visually prior to use.
Croatian: Otopinu prije uporabe treba vizualno pregledati.
English: Amyvid has no or negligible influence on the ability to drive and use machines.
Croatian: Amyvid ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Incorporation of quantitative information generated by CE-marked image quantitation software as an adjunct to the visual interpretation method may improve readers' accuracy.
Croatian: Uklapanje kvantitativnih informacija generiranih uz pomoć softvera s oznakom CE za kvantifikaciju snimaka, kao dopune vizualnoj metodi interpretacije, može poboljšati procjeniteljevu točnost.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Croatian: Od zdravstvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava: navedenog u Dodatku V. 4.9 Predoziranje
English: The activity of florbetapir (18F) has to be measured with an activimeter (dose calibrator) immediately prior to injection.
Croatian: Aktivnost florbetapira (18F) mora se izmjeriti mjeračem aktivnosti (kalibratorom doze) netom prije injekcije.
English: For cases in which there is uncertainty about the location of grey matter and of the grey/white matter border on the PET scan, and a co-registered recent CT or MR image is available, the interpreter should examine the fused PET-CT or PET-MR image to clarify the relationship of the PET radioactivity and the grey matter anatomy.
Croatian: U slučajevima kada se na PET snimci ne može sa sigurnošću odrediti lokacija sive tvari te granica između sive i bijele tvari, a dostupna je nedavno izrađena relevantna CT ili MR snimka, procjenitelj treba proučiti fuzioniranu PET-CT ili PET-MR snimku kako bi razjasnio odnos između radioaktivnosti na PET snimci i anatomije sive tvari.
English: 4.5 Interaction with other medicinal products and other forms of interaction
Croatian: 4.5 Interakcije s drugim lijekovima i drugi oblici interakcija Nisu provedena ispitivanja interakcija in vivo.
English: For an administered activity of 370 MBq the typical radiation doses delivered to the critical organs, gallbladder, upper large intestine wall, lower large intestine wall, small intestine and liver are 53 mGy, 27.5 mGy, 10.3 mGy, 24.2 mGy and 23.8 mGy, respectively.
Croatian: Kod primjene aktivnosti od 370 MBq uobičajene doze zračenja u kritičnim organima su sljedeće: 53 mGy za žučni mjehur, 27,5 mGy za stijenku gornjeg dijela debelog crijeva, 10,3 mGy za stijenku donjeg dijela debelog crijeva, 24,2 mGy za tanko crijevo i 23,8 mGy za jetru.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT ≤28500 MBq at ToC (see outer packaging)
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI DOZNOJ JEDINICI LIJEKA ≤ 28 500 MBq na ToC (vidjeti vanjsko pakiranje)
English: Sensitivity
Croatian: Osjetljivost
English: You must inform the nuclear medicine doctor before you are given Amyvid if there is a possibility you might be pregnant, if you have missed your period or if you are breast-feeding.
Croatian: Morate obavijestiti liječnika specijalista nuklearne medicine prije nego primite Amyvid ako postoji mogućnost da ste trudni, ako Vam je izostala mjesečnica ili ako dojite.
English: Careful consideration of the benefit risk ratio in these patients is required since an increased radiation exposure is possible.
Croatian: U ovih bolesnika treba pomno razmotriti omjer koristi i rizika jer postoji mogućnost povećane izloženosti zračenju.
English: This medicinal product contains up to 37 mg sodium per dose.
Croatian: Ovaj lijek sadrži do 37 mg natrija po dozi.
English: There are strict laws on the use, handling and disposal of radiopharmaceutical products.
Croatian: Kako se primjenjuje Amyvid Postoje strogi zakoni o uporabi, rukovanju i odlaganju radiofarmaceutika.
English: Final panel to right shows enlarged picture of the brain area in the box.
Croatian: Posljednji stupac nadesno prikazuje uvećanu sliku područja mozga označenog kvadratićem.
English: A PET scan with florbetapir (18F) should be requested by physicians skilled in the clinical management of neurodegenerative disorders.
Croatian: PET snimanje uz primjenu florbetapira (18F) mora zatražiti liječnik s iskustvom u kliničkom liječenju neurodegenerativnih poremećaja.
English: Limitations of use
Croatian: Ograničenja primjene
English: Only clear solutions, free of visible particles should be used.
Croatian: Smije se upotrijebiti samo bistra otopina u kojoj nema vidljivih čestica.
English: Agreement with baseline diagnosis of MCI
Croatian: Slaganje s početnom dijagnozom MCI-a
English: Maximal brain uptake of florbetapir (18F) occurs within several minutes of injection, followed by rapid brain clearance during the first 30 minutes following injection.
Croatian: Maksimalno nakupljanje florbetapira (18F) u mozgu događa se unutar nekoliko minuta od injekcije, a nakon toga slijedi brzi klirens iz mozga tijekom prvih 30 minuta nakon injekcije.
English: average reader accuracy on the scans with autopsy standard of truth improved from 90.1% at baseline to 93.1% (p-value <0.0001), with no observed decrease in either sensitivity or specificity.
Croatian: Među svim procjeniteljima koji su imali pristup kvantitativnim informacijama, prosječna točnost očitanja snimaka za koje je postojao obdukcijski nalaz kao standard istine poboljšala se s 90,1% pri početnoj interpretaciji na 93,1% (p-vrijednost < 0,0001), pri čemu nije opaženo smanjenje ni osjetljivosti ni specifičnosti.
English: The biophysical basis of the white matter retention of florbetapir (18F) in the living human brain cannot be definitively explained.
Croatian: Biofizikalna osnova retencije florbetapira (18F) u bijeloj tvari živog ljudskog mozga ne može se sa sigurnošću objasniti.
English: In vivo, correlation was assessed in end-of-life patients between florbetapir (18F) uptake in cortical grey matter and the total β-amyloid burden using 4G8 anti-amyloid antibody that stains β-amyloid found in both neuritic and diffuse plaques.
Croatian: In vivo je u bolesnika u terminalnoj fazi bolesti procijenjena korelacija između nakupljanja florbetapira (18F) u kortikalnoj sivoj tvari i ukupnog β-amiloidnog opterećenja primjenom 4G8 antiamiloidnog protutijela koje oboji β-amiloide i u neuritičkim i difuznim plakovima.
English: If you have been given more Amyvid than you should An overdose is unlikely because you will only receive a single dose of Amyvid precisely controlled by the nuclear medicine doctor supervising the procedure.
Croatian: Predoziranje nije vjerojatno jer ćete primiti samo jednu dozu lijeka Amyvid, i to pod strogim nadzorom liječnika specijalista nuklearne medicine koji će nadgledati postupak.
English: Image interpretation errors in the estimation of brain β-amyloid neuritic plaque density, including false negatives, have been observed.
Croatian: Primijećene su pogreške u interpretaciji snimke kod procjene broja β-amiloidnih neuritičkih plakova u mozgu, uključujući lažno negativne nalaze.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology and single and repeated dose toxicity, in which florbetapir [the non-radioactive form of florbetapir (18F)] was used.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije te toksičnosti jednokratnih i ponovljenih doza u kojima je primijenjen florbetapir
English: Storage of radiopharmaceuticals should be in accordance with national regulation on radioactive materials.
Croatian: Radiofarmaceutike treba čuvati u skladu s nacionalnim propisima o radioaktivnim materijalima.
English: A brain scan is usually taken about 30 to 50 minutes after the Amyvid injection is given.
Croatian: Oslikavanje mozga provodi se približno 30-50 minuta nakon primjene injekcije lijeka Amyvid.
English: Patients should be supine with the head positioned to centre the brain, including the cerebellum, in the PET scanner field of view.
Croatian: Bolesnici moraju ležati na leđima, glave položene na način da se mozak, uključujući mali mozak, nalazi u središtu vidnog polja PET uređaja.
English: Pharmacodynamic effects At the low chemical concentrations present in Amyvid, florbetapir (18F) does not have any detectable pharmacological activity.
Croatian: Pri niskim kemijskim koncentracijama koje su prisutne u lijeku Amyvid, florbetapir (18F) nema primjetnu farmakološku aktivnost.
English: Paediatric population There is no relevant use of Amyvid in the paediatric population.
Croatian: Nema relevantne primjene lijeka Amyvid u pedijatrijskoj populaciji.
English: The PET results were compared with the maximal neuritic plaque density measured on sections of frontal, temporal or parietal cortex at the patient's autopsy within 24 months of PET scan.
Croatian: Rezultati PET oslikavanja uspoređeni su s maksimalnom gustoćom neuritičkih plakova izmjerenom na presjecima čeonog, sljepoočnog ili tjemenog korteksa tijekom obdukcije bolesnika unutar 24 mjeseca nakon PET oslikavanja.
English: This medicine also contains up to 37 mg sodium per dose (as sodium ascorbate and sodium chloride).
Croatian: Ovaj lijek također sadrži do 37 mg natrija po dozi (u obliku natrijeva askorbata i natrijeva klorida).
English: The organs of greatest exposure are organs of elimination, mainly the gallbladder, liver, and intestines.
Croatian: Organi u kojima je izloženost najveća su oni putem kojih se lijek izlučuje, prvenstveno žučni mjehur, jetra i crijeva.
English: No animal studies have been conducted to investigate the reproductive effects of florbetapir (18F) (see section 5.3).
Croatian: Nisu provedena ispitivanja na životinjama kojima bi se ispitali učinci florbetapira (18F) na reprodukciju (vidjeti dio 5.3).
English: A negative scan indicates sparse or no density of cortical β-amyloid plaques.
Croatian: Negativan nalaz oslikavanja upućuje na mali broj ili nepostojanje β-amiloidnih kortikalnih plakova.
English: A pivotal study in 59 end-of-life patients was aimed at establishing the diagnostic performance of Amyvid to detect the cortical neuritic plaque density (no or sparse vs. moderate or frequent).
Croatian: Cilj pivotalnog ispitivanja u kojem je sudjelovalo 59 bolesnika koji se bliže kraju života bio je utvrditi dijagnostičku uspješnost lijeka Amyvid u otkrivanju gustoće kortikalnih neuritičkih plakova (nepostojanje plakova ili mali broj naspram umjerenog ili velikog broja plakova).
English: You must stop breast-feeding for 24 hours after the injection and the maternal milk pumped must be discarded.
Croatian: Ne smijete dojiti tijekom 24 sata nakon injekcije, a izdojeno mlijeko morate baciti.
English: Of the 17 MCI patients who had a positive PET scan, 6 (35%) were diagnosed with clinical probable AD 36 months later compared to 3 (10%) of 30 who had a negative scan.
Croatian: Od 17 bolesnika s MCI-jem u kojih je nalaz PET oslikavanja bio pozitivan 36 mjeseci kasnije je klinički vjerojatan AB dijagnosticiran u njih 6 (35%), u usporedbi s
English: Avoid any close contact with young children and pregnant women for the 24 hours following the injection.
Croatian: Izbjegavati blizak kontakt s malom djecom i trudnicama tijekom 24 sata nakon injekcije.
English: Radionuclide procedures carried out on pregnant women also involve radiation dose to the foetus.
Croatian: Radionuklidne pretrage u trudnica podrazumijevaju dozu zračenja i za plod.
English: Florbetapir (18F) is distributed throughout the body within several minutes of injection, and then is rapidly metabolised.
Croatian: Florbetapir (18F) se raspodjeljuje po cijelom tijelu unutar nekoliko minuta od injekcije, nakon čega se brzo metabolizira.
English: Skin and subcutaneous tissue disorders
Croatian: Poremećaji kože i potkožnog tkiva pruritus urtikarija
English: EXPIRY DATE EXP: ToC + 7.5 h
Croatian: ROK VALJANOSTI Rok valjanosti: ToC + 7,5 h
English: The dose is administered by intravenous bolus injection, followed by a flush of sodium chloride 9 mg/mL (0.9%) solution for injection to ensure full delivery of the dose.
Croatian: Doza se primjenjuje intravenskom bolus injekcijom, a nakon toga se daje otopina natrijeva klorida za injekciju od 9 mg/ml (0,9%) kojom se osigurava primjena cjelokupne doze lijeka.
English: Mechanism of action Florbetapir (18F) binds to β-amyloid neuritic plaques.
Croatian: Florbetapir (18F) se veže za β-amiloidne neuritičke plakove.
English: The following side effect of Amyvid is common (may affect up to 1 in 10 people): - headache
Croatian: Sljedeća nuspojava lijeka Amyvid je česta (može se javiti u do 1 na 10 osoba):
English: The spatial normalisation and fit of the scan to the template should be re-checked to confirm the accuracy of the placement of the regions of interest (ROIs), search for CSF or bone within the ROI, and evaluate the potential impact of atrophy or ventriculomegaly on quantitation.
Croatian: Potrebno je ponovno provjeriti prostornu normalizaciju i preklapanje snimka s predloškom kako bi se potvrdila točnost smještaja regija od interesa, utvrdilo ima li cerebrospinalne tekućine ili kosti unutar regije od interesa te ocijenio mogući utjecaj atrofije ili ventrikulomegalije na kvantifikaciju.
English: Radioactivity in urine is present as polar metabolites of florbetapir (18F).
Croatian: Radioaktivnost je u mokraći prisutna u obliku polarnih metabolita florbetapira (18F).
English: Binding studies using traditional neuropathological staining methods in post-mortem AD brains demonstrated statistically significant (p < 0.0001) correlations between in vitro florbetapir (18F) binding and β-amyloid aggregate deposition.
Croatian: Ispitivanja vezivanja primjenom tradicionalnih metoda neuropatološkog bojanja mozgova oboljelih od Alzheimerove bolesti post mortem pokazala su statistički značajne (p < 0,0001) korelacije između vezivanja florbetapira (18F) in vitro i stvaranja nakupina β-amiloida.
English: The injection of florbetapir (18F) must be intravenous in order to avoid irradiation as a result of local extravasation, as well as imaging artefacts.
Croatian: Injekcija florbetapira (18F) mora se primijeniti intravenski kako bi se izbjeglo ozračivanje kao posljedica lokalne ekstravazacije te pojava artefakata na snimkama.
English: Amyvid is given to adults with memory problems so that doctors can perform a type of brain scan, called a PET scan.
Croatian: Amyvid se daje odraslim osobama koje imaju tegoba s pamćenjem kako bi liječnici mogli provesti oslikavanje mozga koje se naziva PET oslikavanjem.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT ≤ 12000 MBq at ToC (see outer packaging)
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI DOZNOJ JEDINICI LIJEKA ≤ 12 000 MBq na ToC (vidjeti vanjsko pakiranje)
English: Examination of sagittal images and co-registered CT or MR images could help to distinguish occipital bone from occipital grey matter.
Croatian: Pregled sagitalnih snimaka te dostupnih relevantnih CT ili MR snimaka mogao bi olakšati razlikovanje zatiljne kosti od zatiljne sive tvari.
English: Agreement with baseline diagnosis of clinical AD
Croatian: Slaganje s početnom dijagnozom kliničkog AB-a
English: Amyvid must not be used after the expiry date which is stated on the shield label after EXP.
Croatian: Amyvid se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici na zaštitnom spremniku iza oznake „Rok valjanosti“.
English: Advanced Accelerator Applications Ibérica Avda.
Croatian: Advanced Accelerator Applications Ibérica Avda Navarra 3-5 Pol.
English: In AD subjects, as in controls, there is low retention in cerebellum and hippocampus and high retention in pons and centrum semiovale.
Croatian: Alzheimerovom bolešću, kao i u kontrolnih ispitanika, razina retencije u malom mozgu i hipokampusu je niska, dok pons i centrum semiovale imaju visoku razinu retencije.
English: The in vivo binding of florbetapir (18F) to other β-amyloid structures or other brain structures or receptors remains unknown.
Croatian: Vezivanje florbetapira (18F) za druge β-amiloidne strukture te druge strukture ili receptore u mozgu in vivo i dalje je nepoznato.
English: Individual benefit/risk justification
Croatian: 4.4 Posebna upozorenja i mjere opreza pri uporabi Obrazloženje koristi/rizika za pojedinca
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines webportal.
Croatian: • Periodička izvješća o neškodljivosti Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenim člankom 107.c stavkom 7. Direktive
English: Positive likelihood ratio 1.20 (95% CI: 0.76-1.91)
Croatian: 1,20 (95% CI: 0,76-1,91)
English: Florbetapir (18F) is very rapidly cleared from circulation post-intravenous injection.
Croatian: Florbetapir (18F) se iz cirkulacije uklanja vrlo brzo nakon intravenske injekcije.
English: - If you have any further questions, ask your nuclear medicine doctor who will supervise the procedure.
Croatian: - Ako imate dodatnih pitanja, obratite se specijalistu nuklearne medicine koji će nadgledati postupak.
English: In a longitudinal study, 142 subjects (clinically diagnosed as MCI, AD or cognitively normal) underwent baseline florbetapir (18F) PET scans, and were followed for 3 years to evaluate the relationship between Amyvid imaging and changes in diagnostic status.
Croatian: U longitudinalnom su ispitivanju 142 ispitanika (s kliničkom dijagnozom blagog oštećenja kognitivne funkcije (MCI), Alzheimerove bolesti (AB) ili normalne kognitivne funkcije) na početku podvrgnuta PET oslikavanju uz primjenu florbetapira (18F) nakon čega su 3 godine praćeni kako bi se ocijenila povezanost između oslikavanja uz primjenu lijeka Amyvid i promjena dijagnostičkog statusa.
English: If you have any further question on the use of Amyvid, please ask your nuclear medicine doctor who supervises the procedure.
Croatian: U slučaju bilo kakvih pitanja u vezi s primjenom lijeka Amyvid, obratite se liječniku specijalistu nuklearne medicine koji nadgleda postupak.
English: It is supplied in a 10 mL or 15 mL clear glass vial.
Croatian: Dolazi u prozirnoj staklenoj bočici od 10 ml ili 15 ml.
English: In AD subjects, cortical regions and putamen show significantly greater uptake compared to controls.
Croatian: U ispitanika s Alzheimerovom bolešću primijećeno je značajno veće nakupljanje u kortikalnim regijama i putamenu u usporedbi s kontrolnim ispitanicima.
English: Excipients with known effect Each mL of solution contains 79 mg of ethanol and each dose contains up to 37 mg of sodium.
Croatian: Jedan ml otopine sadrži 79 mg etanola i jedna doza sadrži do 37 mg natrija.
English: EXPIRY DATE EXP: ToC + 10 h
Croatian: ROK VALJANOSTI Rok valjanosti: ToC + 10 h
English: It is not known whether florbetapir (18F) is excreted in human milk during breast-feeding.
Croatian: Nije poznato izlučuje li se florbetapir (18F) u majčino mlijeko tijekom dojenja.
English: No differences in SUVR results were noted in subjects taking common AD treatments relative to those not taking AD treatments.
Croatian: Nisu primijećene razlike između omjera SUV-a u bolesnika koji uzimaju uobičajene lijekove za Alzheimerovu bolest i bolesnika koji ih ne uzimaju.
English: Elimination occurs primarily by clearance through the liver and excretion into the gallbladder and the intestines.
Croatian: Lijek se eliminira prvenstveno klirensom kroz jetru i izlučivanjem u žučni mjehur te crijeva.