FrancophonIA/ELRC3.0 huggingface dataset:
English: The physician should bear in mind that the decision to treat women should be based not only on clinical treatment guidelines but also on the determination of the absolute CV risk taking into account gender, age, smoking, blood pressure, cholesterol, etc (e.g. using Score and Framingham).
Slovenian: Zdravnik mora upoštevati, da mora odločitev o zdravljenju žensk temeljiti ne le na smernicah za klinično zdravljenje, ampak tudi na določevanju absolutnega tveganja za srčno-žilno bolezen, pri čemer je treba upoštevati spol, starost, kadilstvo, krvni tlak, holesterol itd. (npr. z uporabo lestvic Score in Framingham).
English: In the atorvastatin group (n=253), there was no progression of atherosclerosis.
Slovenian: V skupini z atorvastatinom (n=253) ateroskleroza ni napredovala.
English: Mortality and morbidity studies with atorvastatin have not yet completed.
Slovenian: Raziskave obolevnosti in umrljivosti z atorvastatinom še niso končane.
English: You should always tell your doctor if you are taking or have recently taken any other medicine, even those not prescribed, because they might interact.
Slovenian: Obvestite svojega zdravnika, če jemljete ali ste pred kratkim jemali katerokoli drugo zdravilo, tudi če ste ga dobili brez recepta, saj lahko pride do medsebojnih učinkov.
English: − if you are pregnant, trying to become pregnant or breast-feeding
Slovenian: − če ste noseči, skušate zanositi ali dojite
English: Ask your doctor or pharmacist for advice before taking any medicine.
Slovenian: Posvetujte z zdravnikom ali s farmacevtom, preden vzamete katerokoli zdravilo.
English: 4.7 Effects on ability to drive and use machines {PRODUCT NAME} has negligible influence on the ability to drive and use machines.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji {(Lastniško) ime} ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: Absolute Risk Reduction p-value
Slovenian: absolutno zmanjšanje tveganja vrednost p
English: The other secondary endpoints did not reach statistical significance on their own (overall: Placebo: 22.2%, Atorvastatin: 22.4%).
Slovenian: Ostali sekundarni opazovani dogodki sami niso bili statistično pomembni (skupno: placebo 22,2%, atorvastatin 22,4%).
English: − if you are a woman able to have children and not using reliable contraception
Slovenian: − če ste ženska v rodni dobi in ne uporabljate zanesljive kontracepcijske zaščite
English: Pharmacotherapeutic group: HMG-CoA-reductase inhibitors, ATC code: C10AA05
Slovenian: Farmakoterapevtska skupina: zaviralci HMG CoA reduktaze, oznaka ATC: C10AA05
English: Other factors that will increase the risk of heart disease include high blood pressure, diabetes, increased weight, lack of exercise, smoking, or a family history of heart disease.
Slovenian: Ostali dejavniki, ki povečujejo tveganje za bolezni srca, so visok krvni pritisk, diabetes, povečana telesna masa, pomanjkanje gibanja, kajenje ali prisotnost bolezni srca v družini.
English: Regarding the interaction observed between atorvastatin and amlodipine, the body of data assessed indicates that this interaction is of questionable clinical relevance, if it exists at all, and does not warrant regulatory action dictating the prescription of the product.
Slovenian: V zvezi z interakcijo, opaženo med atorvastatinom in amlodipinom, zbrani pregledani podatki kažejo, da ima ta interakcija vprašljiv klinični pomen, če le-ta sploh obstaja, in ne more biti podlaga za regulatorne ukrepe, ki bi vplivali na predpisovanje zdravila.
English: Creatine phosphokinase (CPK) should not be measured following strenuous exercise or in the presence of any plausible alternative cause of CPK increase as this makes value interpretation difficult.
Slovenian: Kreatin fosfokinaze (CPK) ne smemo meriti po naporni telesni dejavnosti ali v prisotnosti drugih verjetnih vzrokov za zvišanje CPK, kajti v takšnem primeru je tolmačenje vrednosti težavno.
English: The Applicant has presented arguments for the view that the results for women in ASCOT-LLA based on subgroup analyses are most likely chance findings and are not considered scientifically robust enough to form the basis for regulatory actions.
Slovenian: Vlagatelj je predstavil argumente za stališče, da so rezultati za ženske v raziskavi ASCOT-LLA, pridobljeni v analizi podskupin, najverjetneje posledica naključja in ne štejejo za dovolj znanstveno trdne dokaze, da bi postali osnova za regulatorne ukrepe.
English: − Protease inhibitors used in the treatment of HIV
Slovenian: − zaviralci proteaze HIV, ki se uporabljajo proti virusu HIV
English: However, if there is too much cholesterol in your blood it can be deposited on the walls of the blood vessels, which may eventually become blocked.
Slovenian: Če pa je holesterola v vaši krvi preveč, lahko pride do njegovega odlaganja na stene žil, ki se zato sčasoma lahko zamašijo.
English: This is a very rare reaction, which can be serious if it occurs.
Slovenian: To je zelo redek neželen učinek, ki pa je lahko nevaren.
English: It may harm them, even if their symptoms are the same as yours.
Slovenian: Drugim lahko to zdravilo celo škoduje, tudi če imajo znake bolezni, ki so podobni vašim.
English: {PRODUCT NAME} should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of liver disease.
Slovenian: {(Lastniško) ime} je treba previdno uporabljati pri bolnikih, ki uživajo veliko alkohola in/ali imajo anamnezo o bolezni jeter.
English: Contains one or more components that inhibit CYP3A4 and can increase plasma concentrations of medicinal products metabolized by CYP3A4.
Slovenian: Vsebuje eno ali več sestavin, ki zavirajo CYP3A4, in lahko zveča plazemsko koncentracijo zdravil, ki se presnavljajo s CYP3A4.
English: Experience in pediatrics is limited to a small number of patients (age 4 - 17 years) with severe dyslipidemias, such as homozygous familial hypercholesterolemia.
Slovenian: Izkušnje z uporabo pri otrocih so omejene na maloštevilne bolnike (stare od 4 do 17 let) s hudimi dislipedamijami, npr. s homozigotno familiarno hiperholesterolemijo.
English: There is evidence from animal studies that HMG-CoA reductase inhibitors may influence the development of embryos or foetuses.
Slovenian: Izsledki raziskav na živalih kažejo, da lahko zaviralci HMG CoA reduktaze vplivajo na razvoj zarodka oz. ploda.
English: Therefore, the CHMP favours restricting the indication to patients who have a high risk for a first cardiovascular event, thus forcing the prescriber to perform an individual risk assessment rather than following an algorithm for decision on treatment.
Slovenian: Zato CHMP podpira omejitev indikacije na bolnike, ki imajo veliko tveganje za prvi srčno-žilni dogodek, s čimer se zdravnika, ki zdravilo predpisuje, prisili k individualnemu vrednotenju tveganja in ne k predpisovanju zdravila v skladu z običajnim algoritmom za izbiro zdravljenja.
English: Patients with rare hereditary problems of galactose intolerance, Lapp lactose deficiency or glucosegalactose malabsorption should not take this medicine.
Slovenian: Bolniki z redkimi dednimi težavami, kot so galaktozna intoleranca, Lappovo pomanjkanje laktaze ali glukozno-galaktozna malabsorpcija, ne smejo jemati tega zdravila.
English: Therefore, the benefit and the risk of concurrent treatment should be carefully weighed (see section 4.4).
Slovenian: Zato je treba natančno pretehtati koristi in tveganja sočasnega zdravljenja (glejte poglavje 4.4).
English: − Occasionally, patients have developed muscle wasting or inflammation, and very rarely this has progressed to become a serious, potentially life-threatening condition (called ‘rhabdomyolysis').
Slovenian: − Občasno je pri bolnikih prišlo do propadanja mišic ali vnetja, in zelo redko je le-to vodilo v hudo, potencialno življensko nevarno stanje (imenovano rabdomioliza).
English: The safety of atorvastatin in pregnancy and lactation has not yet been proven.
Slovenian: Varnost atorvastatina med nosečnostjo in dojenjem ni dokazana.
English: In clinical studies in which {PRODUCT NAME} was administered with antihypertensives or hypoglycaemic agents no clinically significant interactions were seen.
Slovenian: V kliničnih raziskavah, v katerih so {(Lastniško) ime} uporabljali hkrati z antihipertenzivi ali antidiabetiki, niso ugotovili klinično pomembnih interakcij.
English: It is not known whether this medicinal product or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se to zdravilo ali njegovi presnovki pri ljudeh človeku izločajo v materinem mleku.
English: Erythromycin, clarithromycin
Slovenian: Eritromicin, klaritromicin
English: − Medicines used to alter the way your immune system works, e.g. ciclosporin
Slovenian: − zdravila, ki spremenijo delovanje vašega imunskega sistema, npr. ciklosporin
English: − If symptoms resolve and CPK levels return to normal, then re-introduction of atorvastatin or introduction of an alternative statin may be considered at the lowest dose and with close monitoring.
Slovenian: - Če simptomi minejo in se CPK normalizira, pretehtamo možnost ponovne uvedbe atorvastatina ali uvedbe kakšnega drugega statina v najmanjšem odmerku in ob natančnem nadzoru.
English: − If you have kidney problems
Slovenian: − če imate težave z ledvicami
English: Uncommon: impotence.
Slovenian: Občasno: impotenca.
English: − if you have or have ever had a disease which affects the liver
Slovenian: − če imate ali ste kdaj imeli kakšno bolezen jeter
English: − If you have had repeated or unexplained muscle aches or pains, a personnal history or family history of muscle problems
Slovenian: − če ste imeli ponavljajoče se in nepojasnjene bolečine v mišicah ter osebno ali družinsko zgodovino težav z mišicami
English: Hospital packs containing 200 (10 x 20) or 500 film-coated tablets.
Slovenian: Bolnišnična pakiranja z 200 (10 x 20) ali 500 filmsko obloženimi tabletami.
English: The possible interaction with other substrates of this isozyme is unknown but should be considered for other medicinal products with a narrow therapeutic index, for example, antiarrhythmic agents Class III including amiodarone.
Slovenian: Morebitne interakcije z drugimi substrati tega izoencima niso znane, vendar jih je treba upoštevati pri drugih zdravilih z nizkim terapevtskim indeksom, npr. pri antiaritmikih iz skupine III, vključno z amiodaronom.
English: Atorvastatin was administered at doses up to 80 mg/day.
Slovenian: Atorvastatin je bil uporabljen v odmerkih do 80 mg/dan.
English: At its meeting of 20-23 March 2006, the CHMP considered the data on efficacy presented by the MAHs and concluded that it had been shown that atorvastatin, as an adjunct to correction of other risk factors, was effective in the prevention of CV events in patients estimated to have a high risk for a first CV event.
Slovenian: CHMP je na svoji seji 20.-23. marca 2006 upošteval podatke o učinkovitosti, ki so jih predložili imetniki dovoljenja za promet z zdravilom, in je bil mnenja, da podatki dokazujejo učinkovitost atorvastatina kot dopolnila h korekciji drugih dejavnikov tveganja za preprečevanje srčno-žilnih dogodkov pri bolnikih z velikim ocenjenim tveganjem za prvi srčno-žilni dogodek.
English: Not all included patients were estimated to have a high risk for a first cardiovascular event.
Slovenian: Niso ocenili, da pri vseh vključenih bolnikih obstaja visoko tveganje za prvi kardiovaskularni dogodek
English: Mean plasma elimination half-life of atorvastatin in humans is approximately 14 hours.
Slovenian: Povprečni eliminacijski razpolovni čas atorvastatina pri ljudeh je približno 14 ur.
English: The main issue discussed by the CHMP has been the results of the ASCOT-LLA trial, most importantly the lack of established benefit and adverse mortality trends in the female subgroup and, secondly, the impact of the observed interaction between the antihypertensive amlodipine and atorvastatin on the main trial outcomes for certain subgroups.
Slovenian: Glavna tema razprave CHMP so bili rezultati preskušanja ASCOT-LLA, zlasti pomanjkanje dokazov o koristnih učinkih in neželeni trendi smrtnosti pri ženskah, na drugem mestu pa vpliv opažene interakcije med antihipertenzivno učinkovino amlodipin in atorvastatinom na glavne kazalce izida v določnih podskupinah.
English: A point of minor discussion was the applicability of the trial results to other strengths of atorvastatin.
Slovenian: Manjša razprava se je vrtela okrog sprejemljivosti rezultatov preskušanja za druge jakosti atorvastatina.
English: This may possibly lead to increased plasma levels of atorvastatin (see section 4.4).
Slovenian: To bi lahko povzročilo zvišano koncentracijo atorvastatina v plazmi (glejte tudi poglavje 4.4).
English: The absolute bioavailability of atorvastatin is approximately 12% and the systemic availability of HMG-CoA reductase inhibitory activity is approximately 30%.
Slovenian: Absolutna biološka uporabnost atorvastatina je približno 12%, sistemska uporabnost zaviralnega delovanja na HMG CoA reduktazo pa približno 30%.
English: Clarithromycin increased the Cmax and AUC of atorvastatin by 56% and 80% respectively.
Slovenian: Klaritromicin je povečal Cmax atorvastatina za 56% in njegovo AUC za 80%.
English: ANNEX II SCIENTIFIC CONCLUSIONS AND GROUNDS FOR AMENDMENT OF THE SUMMARY OF PRODUCT CHARACTERISTICS PRESENTED BY THE EMEA
Slovenian: DODATEK II ZNANSTVENI ZAKLJUČKI IN PODLAGA ZA DOPOLNITEV POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA, PREDSTAVLJENI S STRANI EVROPSKE AGENCIJE ZA ZDRAVILA
English: When compared to pravastatin the effects of atorvastatin were statistically significant (p=0.02).
Slovenian: Učinki atorvastatina so bili v primerjavi z učinki pravastatina statistično pomembni (p=0,02).
English: Despite agreeing to the Applicant's request not to exclude females and non-diabetics from the indication, the CHMP regards the claimed indication, which mirrors the ASCOT-LLA and CARDS patient populations, to be too broad.
Slovenian: Kljub temu, da se CHMP strinja z vlagateljevo zahtevo, da se iz indikacije ne izključi žensk in bolnikov brez sladkorne bolezni, CHMP meni, da je prijavljena indikacija, ki odraža populacije bolnikov v raziskavah ASCOT-LLA in CARDS, preširoka.
English: It is obvious that the age-adjusted absolute benefit of primary CVD prevention is much lower in women than in men, as women have a lower CVD risk at the same age.
Slovenian: Očitno je, da je absolutni koristni učinek primarnega preprečevanja srčno-žilnih bolezni, ki je prilagojen glede na starost, veliko manjši pri ženskah kakor pri moških, saj imajo ženske pri enaki starosti manjše tveganje za srčno-žilne bolezni.
English: If you are at an increased risk of heart disease, {PRODUCT NAME}can also be used to reduce such risk even if your cholesterol levels are normal.
Slovenian: Če imate povišano tveganje za srčne bolezni, se lahko {(Lastniško) ime} uporablja tudi za zmanjševanje takšnega tveganja, čeprav je raven holesterola v vaši krvi normalna.
English: <[To be completed nationally]> {Name and Address} <{tel}> <{fax}> <{e-mail}>
Slovenian: [Izpolni država članica] {Ime in naslov} <{tel.}> <{fax}> <{e-mail}>
English: This was mainly due to a 26% reduction in re-hospitalisation for angina pectoris with evidence of myocardial ischaemia (p=0.018).
Slovenian: Razlog za to je bilo predvsem 26-odstotno zmanjšanje števila ponovnih hospitalizacij zaradi angine pektoris z znaki ishemije miokarda (p=0,018).
English: In order to put the results from ASCOT-LLA into a wider perspective and to further support the safety and benefit of atorvastatin in the primary prevention of CV events, regardless of gender, the Applicant has provided i) a brief review of data with respect to gender from other statin clinical trials, ii) the current position of scientific societies on the recommended management of CVD in women, iii) key results by gender for ASCOT-LLA and CARDS, highlighting similarities between the studies, and iv) reference to current regulatory guidance and scientific limitations in interpreting results from subgroup analyses.
Slovenian: Z namenom oceniti rezultate raziskave ASCOT-LLA s širšega vidika in ponuditi dodatne dokaze za varnost in koristne učinke atorvastatina v primarnem preprečevanju srčno-žilnih dogodkov ne glede na spol je vlagatelj predložil i) kratek pregled podatkov po spolu iz drugih kliničnih preskušanj statinov, ii) trenutno stališče strokovne skupnosti o priporočeni obravnavi srčno-žilnih bolezni pri ženskah, iii) ključne rezultate raziskav ASCOT-LLA in CARDS po spolu, pri čemer so bile izpostavljene podobnosti med obema raziskavama ter iv) sklic na trenutne regulatorne smernice in znanstvene omejitve pri interpretaciji rezultatov analize podskupin.
English: − If you experience problems with unexpected or unusual bleeding or bruising, this may be suggestive of a liver complaint.
Slovenian: − Če pride do težav z nepričakovanim ali nenavadnim krvavenjem ali podplutbami, lahko to kaže na težave z jetri.
English: After oral administration, atorvastatin film-coated tablets are 95% to 99% bioavailable compared to the oral solution.
Slovenian: Po peroralni uporabi filmsko obloženih tablet atorvastatina je njegova biološka uporabnost v primerjavi z raztopino od 95 do 99%.
English: OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF ATORVASTATIN (Sortis and associated names - see Annex I)
Slovenian: SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ATORVASTATINA (zdravilo Sortis in povezana imena - glejte Dodatek I)
English: If you have muscle weakness, tenderness or pain and particularly, if at the same time, you feel unwell or have a high temperature, stop taking {PRODUCT NAME} and tell your doctor immediately.
Slovenian: Če čutite šibkost v mišicah, občutljivost na dotik ali bolečino, in še posebej, če to spremljata slabo počutje in vročina, prenehajte jemati {(Lastniško) ime} in takoj obvestite svojega zdravnika.
English: Atorvastatin increased mean HDL-C by 2.9% (pravastatin: +5.6%, p=NS).
Slovenian: Atorvastatin je zvišal povprečni holesterol HDL za 2,9% (pravastatin: +5,6%, p=NZ).
English: Concomitant administration of atorvastatin 40 mg and itraconazole 200 mg daily resulted in a 3-fold increase in atorvastatin AUC.
Slovenian: Sočasna uporaba 40 mg atorvastatina in 200 mg itrakonazola na dan je povzročila 3-kratno zvečanje AUC atorvastatina.
English: Intake of one 240 ml glass of grapefruit juice resulted in an increase in atorvastatin AUC of 37% and a decreased AUC of 20.4% for the active orthohydroxy metabolite.
Slovenian: Zaužitje 240-ml kozarca grenivkinega soka je AUC atorvastatina zvečalo za 37%, AUC aktivnega ortohidroksi presnovka pa zmanjšalo za 20,4%.
English: − Angioneurotic oedema (swelling of the face, tongue and windpipe which can cause great difficulty in breathing).
Slovenian: − Angionevrotični edem (oteklina obraza, jezika in sapnika, ki lahko povzroči velike težave pri dihanju).
English: − If you have an under-active thyroid gland (hypothyroidism)
Slovenian: − če imate premalo aktivno žlezo ščitnico (hipotiroidizem)
English: Estimated frequencies of events are ranked according to the following convention: common (≥ 1/100, < 1/10); uncommon (≥ 1/1,000, < 1/100); rare (≥ 1/10,000, < 1/1,000); very rare (≤ 1/10,000).
Slovenian: Ocenjene pogostnosti neželenih učinkov so po dogovoru razvrščene, kot sledi: pogosti (≥ 1/100, < 1/10); občasni (≥ 1/1000, < 1/100); redki (≥ 1/10000, < 1/1000); zelo redki (≤ 1/10000).
English: 4 tablets 7 tablets 10 tablets 14 tablets 20 tablets 28 tablets 30 tablets 50 tablets 56 tablets 84 tablets 98 tablets 100 tablets 200 tablets 500 tablets
Slovenian: 4 tablete 7 tablet 10 tablet 14 tablet 20 tablet 28 tablet 30 tablet 50 tablet 56 tablet 84 tablet 98 tablet 100 tablet 200 tablet 500 tablet
English: − if you have had any unexplained abnormal blood tests for liver function
Slovenian: − če ste kdaj dobili nenormalne in nepojasnjene izvide krvnih preiskav za delovanje jeter
English: Uncommon: tinnitus
Slovenian: Občasno: tinitus
English: − If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this product.
Slovenian: − če vam je zdravnik povedal, da imate intoleranco za nekatere sladkorje, se z njim posvetujte,
English: The appropriate place for dose recommendations is section 4.2 of the SPC, not section 4.1, and adequate dosing recommendations have been added.
Slovenian: Ustrezno mesto za priporočila glede odmerjanja je poglavje 4.2 v Povzetku glavnih značilnosti zdravila in ne poglavje 4.1.
English: Uncommon: amnesia.
Slovenian: Občasno: amnezija.
English: Creatine phosphokinase measurement
Slovenian: Merjenje kreatin fosfokinaze
English: Relative Risk Reduction
Slovenian: Relativno zmanjšanje tveganja
English: Levels above 10 times the normal upper range occurred in 0.4% {PRODUCT NAME}-treated patients (see section 4.4).
Slovenian: Zvišanje nad 10-kratno ZNM se je pojavilo pri 0,4% bolnikov, zdravljenih s {(Lastniško) ime} (glejte poglavje 4.4).
English: In rats, plasma concentrations of atorvastatin and its active metabolites are similar to those in milk.
Slovenian: Pri podganah je bila koncentracija atorvastatina in njegovih aktivnih presnovkov v plazmi podobna kot v mleku.
English: Prevention of cardiovascular disease
Slovenian: Preprečevanje kardiovaskularnih bolezni
English: CHD = coronary heart disease; MI = myocardial infarction.
Slovenian: CHD = koronarna srčna bolezen; MI = miokardni infarkt.
English: From these 46 patients, the mean percent reduction in LDL-C was approximately 21%.
Slovenian: Povprečno znižanje holesterola LDL pri teh 46 bolnikih je bilo približno 21%.
English: Should an increase in transaminases of greater than 3 times the upper limit of normal persist, reduction of dose or withdrawal of {PRODUCT NAME} is recommended (see section 4.8).
Slovenian: Če zvišanje transaminaz, ki presega 3-kratno ZNM, traja, je odmerek {(Lastniško) ime} priporočljivo zmanjšati ali zdravilo ukiniti (glejte poglavje 4.8).
English: Therefore, the CHMP agrees that excluding females from the indication would deprive an important sub-group of the population of atorvastatin treatment if their CV risk warrants this treatment, and believes the above findings in the female subgroup of ASCOTLLA should be reflected in section 5.1 of the SPC.
Slovenian: Zato se CHMP strinja, da bi izključitev žensk iz indikacije, pomembno podskupino populacije prikrajšala za zdravljenje z atorvastatinom, če je njihovo tveganje za srčno-žilno bolezen utemeljena podlaga za takšno zdravljenje, ter je mnenja, da naj se zgoraj omenjeni rezultati za ženske v raziskavi ASCOT-LLA prikažejo v poglavju 5.1 Povzetka glavnih značilnosti zdravila.
English: Nevertheless, patients receiving warfarin should be closely monitored when {PRODUCT NAME} is added to their therapy.
Slovenian: Kljub temu je treba bolnike, ki dobivajo varfarin, po dodatku {(Lastniško) ime} v terapijo natančno nadzorovati.
English: To what extent the claimed therapeutic indication could be applied to atorvastatin doses other than the one tested in the CARDS and ASCOT-LLA trials.
Slovenian: Do kakšne mere se lahko prijavljena terapevtska indikacija uporabi za tiste odmerke atorvastatina, ki niso bili raziskani v preskušanjih CARDS in ASCOT-LLA?
English: In animal studies atorvastatin had no effect on male or female fertility at doses up to 175 and 225 mg/kg/day, respectively, and was not teratogenic.
Slovenian: V raziskavah na živalih atorvastatin v odmerkih do 175 mg/kg/dan pri samcih in do 225 mg/kg/dan pri samicah ni vplival na plodnost in ni bil teratogen.
English: However, large quantities of grapefruit juice (over 1.2 l daily for 5 days) increased AUC of atorvastatin 2.5 fold and AUC of active (atorvastatin and metabolites) HMG-CoA reductase inhibitors 1.3 fold.
Slovenian: Vendar pa so velike količine zaužitega grenivkinega soka (več kot 1,2 litra na dan pet dni) AUC atorvastatina zvečale za 2,5-krat in AUC aktivnih zaviralcev HMG CoA reduktaze (atorvastatina in metabolitov) za 1,3-krat.
English: Very rare: angioneurotic oedema, bullous rashes (including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis).
Slovenian: Zelo redko: angionevrotski edem, bulozni izpuščaji (vključno z multiformnim eritemom, StevensJohnsonovim sindromom in toksično epidermalno nekrolizo).