FrancophonIA/ELRC3.0 huggingface dataset:
English: • decrease in blood pressure; irregular or rapid heart beat
Croatian: • pad krvnog tlaka; nepravilni ili brzi srčani otkucaji
English: All except one patient in each arm were diagnosed with CHF more than 30 days after the treatment period.
Croatian: Svim bolesnicima, osim po jednog bolesnika u svakoj skupini, CHF je bio dijagnosticiran nakon više od 30 dana od vremena liječenja.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 28 August 2015
Croatian: DATUM PRVOG ODOBRENJA / DATUM OBNOVE ODOBRENJA
English: In this study, 87% of patients had disease that was IHC 3+, and 95% of patients entered had disease that was IHC 3+ and/or FISH positive.
Croatian: U ovom ispitivanju 87% bolesnika imalo je IHC 3+, a 95% uključenih bolesnika imalo je IHC 3+ i/ili FISH pozitivne rezultate.
English: The first interim analysis was planned 3 years after the date when half of study enrollment was done.
Croatian: Prva privremena analiza planirala se provesti 3 godine nakon datuma pri kojem je polovica bolesnika uključena u ispitivanje.
English: Before each treatment with Taxespira, you will have blood tests to check that you have enough blood cells and sufficient liver function to receive Taxespira.
Croatian: Prije svake primjene lijeka Taxespira, obavit ćete krvne pretrage kako bi se provjerilo imate li dovoljno krvnih stanica te odgovarajuću funkciju jetre kako biste mogli primiti Taxespira.
English: 2D barcode carrying the unique identifier included.
Croatian: Sadrži 2D barkod s jedinstvenim identifikatorom.>
English: • infections, decrease in the number of red blood cells (anaemia), or white blood cells (which are important in fighting infection) and platelets (important in blood clotting)
Croatian: • infekcije, smanjenje broja crvenih krvnih stanica (anemija) ili bijelih krvnih stanica (koje su važne u borbi protiv infekcija) i krvnih pločica
English: If crystals appear, the solution must no longer be used and shall be discarded.
Croatian: Ako se pojave kristali, otopina se ne smije primijeniti i mora se baciti.
English: Between infusions of Taxespira the following may occur, and the frequency may vary with the combinations of medicines that are received:
Croatian: Između infuzija lijeka Taxespira mogu se pojaviti sljedeće nuspojave, a učestalost može varirati ovisno o kombinacijama lijekova koje ste primili:
English: • inflammation of the eye or increased tearing of the eyes
Croatian: • upala oka ili povećano suzenje očiju
English: Primary prophylactic G-CSF was made mandatory in TAC arm after 230 patients were randomized.
Croatian: Primarna GCSF profilaksa uvedena je kao obavezna u TAC skupini nakon što je randomizirano 230 bolesnika.
English: Your doctor may change the dose and frequency of dosing depending on your blood tests, your general condition and your response to Taxespira.
Croatian: Vaš liječnik može mijenjati dozu i učestalost primjene lijeka ovisno o rezultatima krvnih pretraga, Vašem općem stanju i terapijskom odgovoru na Taxespira.
English: Docetaxel is highly protein bound (>95%).
Croatian: Docetaksel se izrazito veže za proteine (> 95%).
English: Taxespira contains ethanol (alcohol)
Croatian: Taxespira sadrži etanol (alkohol)
English: Contraceptive measures must be taken by both men and women during treatment and for men at least 6 months after cessation of therapy (see section 4.6).
Croatian: Tijekom liječenja, muškarci i žene trebaju primjenjivati kontracepcijska sredstva, a muškarci i još najmanje 6 mjeseci nakon prekida liječenja (vidjeti dio 4.6).
English: This may be moderate to severe and has been associated with death (see section 4.8).
Croatian: Ono može biti umjereno do teško, a bilo je povezano sa smrtnim ishodom (vidjeti dio 4.8).
English: This leaflet is available in all EU/EEA languages on the European Medicines Agency website.
Croatian: Ova Uputa o lijeku dostupna je na svim jezicima EU-a/EGP-a na internetskim stranicama Europske agencije za lijekove.
English: These symptoms may be the first signs of a serious gastrointestinal toxicity, which could be fatal.
Croatian: Ovi simptomi mogu biti znakovi ozbiljne toksičnosti u probavnom sustavu koja može biti smrtonosna.
English: The primary analysis was done when all patients had a follow-up of greater than 5 years (median follow-up time of 77 months).
Croatian: Primarna analiza napravljena je nakon što su svi bolesnici imali period praćenja dulji od 5 godina (medijan vremena praćenja od 77 mjeseci).
English: Taxespira will be administered to you by a healthcare professional.
Croatian: Taxespira će Vam davati zdravstveni radnik.
English: Treatment difference: 7.1% [95% CI: 0.7; 13.5] *: Corrected for multiple comparisons and adjusted for stratification factors (stage of disease and region of treatment), based on evaluable patient population.
Croatian: Razlika u liječenju: 7,1% [95% CI: 0,7; 13,5] * Korigirano za višestruku usporedbu i prilagođeno faktorima stratifikacije (stadij bolesti i regija liječenja) na osnovu podataka iz populacije bolesnika koji su se mogli procijeniti
English: Neutropenia (Grade 4) Febrile neutropenia Neutropenic infection Neutropenic infection (Grade 3-4)
Croatian: Neutropenija (stupanj 4) Febrilna neutropenija Neutropenijska infekcija Neutropenijska infekcija (stupanj 3-4)
English: What you need to know before you use Taxespira
Croatian: Što morate znati prije nego počnete primati Taxespira
English: • injection site reactions at the site of a previous reaction.
Croatian: • reakcije na mjestu davanja injekcije na mjestu prethodne reakcije.
English: Limited data from a single uncontrolled study were suggestive of an interaction between docetaxel and carboplatin.
Croatian: Ograničeni podaci iz jedinog nekontroliranog ispitivanja ukazivali su na interakciju između docetaksela i karboplatine.
English: 3) was 7 days), anaemia, alopecia, nausea, vomiting, stomatitis, diarrhoea and asthenia.
Croatian: 3) je bio 7 dana), anemija, alopecija, mučnina, povraćanje, stomatitis, proljev i astenija.
English: Hazard ratio (TAC/FAC)
Croatian: FAC Omjer hazarda (TAC/FAC)
English: Meeting relative indication for chemotherapy No
Croatian: Zadovoljena relativna indikacija za kemoterapiju a Ne
English: Use the vial immediately after its opening.
Croatian: Primijeniti bočicu odmah nakon otvaranja.
English: This regimen was administered every three weeks for 4 cycles in case at least a minor response (≥25% reduction in bidimensionally measured tumour size) was observed after 2 cycles.
Croatian: Taj režim je primjenjivan svaka tri tjedna,tijekom 4 ciklusa u slučaju da je barem minimalni odgovor (≥ 25% smanjenje dvodimenzionalno mjerene veličine tumora) bio primijećen nakon 2 ciklusa.
English: You must not be given Taxespira
Croatian: Ne smijete primiti Taxespira
English: If the patient continues to experience these reactions at 60 mg/m 2, the treatment should be discontinued.
Croatian: 2. Ako se u bolesnika pri primjeni doze od 60 mg/m 2 i dalje javljaju ove reakcije, liječenje treba prekinuti.
English: G-CSF was used for secondary prophylaxis in 19.3% of patients (10.7 % of the cycles).
Croatian: G-CSF se primjenjivao kao sekundarna profilaksa u 19,3% bolesnika (10,7% ciklusa).
English: Docetaxel plus trastuzumab n = 92
Croatian: Docetaksel plus trastuzumab n = 92
English: permanent hair loss has been observed
Croatian: (nepoznata učestalost) primijećen je trajan gubitak kose.
English: If not used immediately, in-use storage times and conditions are the responsibility of the user and would normally not be longer than 6 hours below 25°C including the one hour infusion.
Croatian: Ako se ne primijeni odmah, vrijeme i uvjeti čuvanja odgovornost su korisnika i ne bi smjeli biti dulji od 6 sati na temperaturi ispod 25°C što uključuje i jedan sat trajanja infuzije.
English: The study population comprised patients with technically unresectable disease, patients with low probability of surgical cure and patients aiming at organ preservation.
Croatian: Populacija u ispitivanju uključivala je bolesnike s tehnički neoperabilnom bolešću, bolesnike s malom vjerojatnošću kirurškog izlječenja i bolesnike u kojih se težilo očuvanju organa.
English: Toxicity Diarrhoea grade 3
Croatian: Toksičnost Proljev stupnja 3
English: Reactions were characterised by a rash including localised eruptions mainly on the feet and hands (including severe hand and foot syndrome), but also on the arms, face or thorax, and frequently associated with pruritus.
Croatian: Reakcije je karakterizirala pojava osipa, uključujući lokalizirane erupcije, najčešće na stopalima i šakama (uključujući teški sindrom šaka/stopalo), ali i na rukama, licu ili grudnom košu, a često su bile povezane sa svrbežom.
English: Overall response rate (CR+PR) (%) p-value
Croatian: Ukupna stopa odgovora (CR+PR) (%) p-vrijednost
English: In about 20% of these cases there were no risk factors for acute renal failure such as concomitant nephrotoxic medicinal products and gastro-intestinal disorders.
Croatian: U otprilike 20% ovih slučajeva nije bilo faktora rizika za akutno zatajenje bubrega, kao što su istodobno primijenjeni nefrotoksični lijek i poremećaji probavnog sustava.
English: Hypersensitivity reactions may occur within a few minutes following the initiation of the infusion of docetaxel, thus facilities for the treatment of hypotension and bronchospasm should be available.
Croatian: Reakcije preosjetljivosti mogu se pojaviti unutar nekoliko minuta nakon početka primjene infuzije docetaksela, pa treba imati dostupnu opremu i sredstva za liječenje hipotenzije i bronhospazma.
English: These patients should be closely monitored during initiation of docetaxel therapy.
Croatian: Te bolesnike je potrebno pobliže pratiti na početku terapije docetakselom.
English: The amount of alcohol in this medicinal product may impair your ability to drive or use machines.
Croatian: Količina alkohola u ovom lijeku može smanjiti Vašu sposobnost upravljanja vozilima ili rada sa strojevima.
English: Overall, the study results demonstrate a positive benefit risk ratio for TAC compared to FAC.
Croatian: Sveukupno, rezultati ispitivanja pokazuju pozitivni omjer koristi/rizika za TAC skupinu u usporedbi s FAC skupinom.
English: Patients who received docetaxel every three weeks demonstrated significantly longer OS compared to those treated with mitoxantrone.
Croatian: Bolesnici koji su primali docetaksel svaka tri tjedna pokazali su značajno dulje ukupno preživljenje u odnosu na bolesnike liječene mitoksantronom.
English: Toxic deaths occurred in 1 patient in the AT arm (congestive heart failure) and in 4 patients in the AC arm (1 due to septic shock and 3 due to congestive heart failure).
Croatian: Toksična smrt zabilježena je u jednog bolesnika u AT skupini (kongestivno zatajenje srca) i u 4 bolesnika u AC skupini (jedna zbog septičnog šoka i 3 zbog kongestivnog zatajenja srca).
English: • For any subsequent appearances of toxicities, or any Grade 4 toxicities, discontinue the docetaxel dose.
Croatian: • Za svaku sljedeću pojavu toksičnosti, ili bilo koju pojavu toksičnosti stupnja 4, potrebno je prekinuti terapiju docetakselom.
English: Acute leukaemia /Myelodysplastic syndrome
Croatian: Akutna leukemija/mijelodisplastični sindrom
English: 3 for seven days or more) during a course of docetaxel therapy, a reduction in dose for subsequent courses of therapy or the use of appropriate symptomatic measures are recommended (see section 4.2).
Croatian: 3 u trajanju od sedam dana ili dulje) za vrijeme liječenja docetakselom, preporuča se smanjenje doze u sljedećim ciklusima liječenja ili primjena odgovarajućih simptomatskih mjera (vidjeti dio 4.2).
English: See also section “Taxespira contains ethanol (alcohol)” below.
Croatian: Pogledajte dio „Taxespira sadrži etanol (alkohol)” u nastavku.
English: Second episode: stop 5-FU only, at all subsequent cycles.
Croatian: Druga epizoda: prekinuti samo primjenu 5-FU u svim sljedećim
English: You will be asked to take premedication consisting of an oral corticosteroid such as dexamethasone, one day prior to Taxespira administration and to continue for one or two days after it in order to minimise certain undesirable effects which may occur after the infusion of Taxespira in particular allergic reactions and fluid retention (swelling of the hands, feet, legs or weight gain).
Croatian: Od Vas će se tražiti da uzmete premedikaciju koja se sastoji od oralnih kortikosteroida, poput deksametazona, dan prije primjene lijeka Taxespira te još dan ili dva nakon toga, kako bi se smanjile određene nuspojave, koje se mogu pojaviti nakon infuzije lijeka Taxespira, osobito alergijske reakcije i zadržavanje tekućine u tijelu (oticanje ruku, stopala, nogu ili povećanje tjelesne težine).
English: Tell your doctor, hospital pharmacist or nurse if you have experienced an allergic reaction to previous paclitaxel therapy.
Croatian: Obavijestite svog liječnika, bolničkog ljekarnika ili medicinsku sestru ako ste doživjeli alergijsku reakciju na prethodno liječenje paklitakselom.
English: The onset of moderate and severe retention is delayed (median cumulative dose: 818.9 mg/m2) in patients with premedication compared with patients without premedication (median cumulative dose: 489.7 mg/m2); however, it has been reported in some patients during the early courses of therapy.
Croatian: Pojava umjerene i teške retencije je odgođena (medijan kumulativne doze: 818,9 mg/m2) u bolesnika koji su primili premedikaciju u odnosu na bolesnike koji nisu primili premedikaciju (medijan kumulativne doze: 489,7 mg/m2); retencija je, međutim, bila zabilježena u nekih bolesnika tijekom ranog stupnja liječenja.
English: In non-clinical studies, docetaxel has genotoxic effects and may alter male fertility (see section 5.3).
Croatian: Neklinička ispitivanja pokazuju da docetaksel ima genotoksične učinke i da može utjecati na plodnost muškaraca (vidjeti dio 5.3).
English: Ethanol (anhydrous) Citric acid monohydrate
Croatian: Etanol (bezvodni) Citratna kiselina hidrat
English: Patients who have previously experienced a hypersensitivity reaction to paclitaxel may be at risk to develop hypersensitivity reaction to docetaxel, including more severe hypersensitivity reaction.
Croatian: Bolesnici koji su prethodno doživjeli reakciju preosjetljivosti na paklitaksel mogu biti u riziku od razvoja reakcije preosjetljivosti na docetaksel, uključujući i teže reakcije preosjetljivosti.
English: The most commonly reported adverse reactions of docetaxel alone are: neutropenia (which was reversible and not cumulative; the median day to nadir was 7 days and the median duration of severe neutropenia (<500 cells/mm
Croatian: Najčešće prijavljene nuspojave samog docetaksela su: neutropenija (koja je bila reverzibilna i nije bila kumulativna; medijan javljanja najnižih vrijednosti je bio 7 dana, a medijan trajanja teške neutropenije (<500 stanica/mm
English: For docetaxel/carboplatin combination, neither equivalent nor non-inferior efficacy could be proven compared to the reference treatment combination VCis.
Croatian: Za kombinaciju docetaksel/karboplatin nije se mogla dokazati ekivalentna ili neinferiorna djelotvornost u usporedbi s referentnom kombinacijom liječenja VCis.
English: Dehydration and pulmonary oedema have rarely been reported.
Croatian: Dehidracija i plućni edem zabilježeni su rijetko.
English: Ready to add to infusion solution.
Croatian: Spremno za dodavanje u infuzijsku otopinu.
English: • pneumonia (infection of the lungs)
Croatian: • pneumonija (upala pluća)
English: Discuss with your doctor if you suffer from alcohol dependency, epilepsy, or liver impairment.
Croatian: Razgovarajte sa svojim liječnikom ako ste ovisni o alkoholu ili imate oštećenje jetre.
English: Median survival was 442 days (docetaxel + capecitabine) vs. 352 days (docetaxel alone).
Croatian: Medijan preživljenja je bio 442 dana (docetaksel + kapecitabin) naspram 352 dana (samo docetaksel).
English: Of the 333 patients treated with docetaxel every three weeks in a prostate cancer study, 209 patients were 65 years of age or greater and 68 patients were older than 75 years.
Croatian: Od 333 bolesnika koji su docetaksel primali svaka tri tjedna u ispitivanju liječenja karcinoma prostate, 209 bolesnika bilo je u dobi od 65 godina ili starije, a 68 bolesnika bilo je starije od 75 godina.
English: Injection site recall reaction (recurrence of skin reaction at a site of previous extravasation following administration of docetaxel at a different site) has been observed at the site of previous extravasation (frequency not known).
Croatian: Odzivna upalna reakcija na mjestu injiciranja (ponovna pojava kožne reakcije na mjestu prethodne ekstravazacije nakon primjene docetaksela na drugom mjestu) zapažena je na mjestu prethodne ekstravazacije (učestalost nepoznata).
English: The ORR was 59.3% (95% CI: 52.8 - 65.9) in AT arm versus 46.5% (95% CI: 39.8 - 53.2) in
Croatian: ORR je bio 59,3 % (95% CI: 52,8-65,9) u AT skupini u odnosu na 46,5% (95% CI: 39,8-53,2) u AC skupini.
English: Patients should be closely monitored for early manifestations of serious gastrointestinal toxicity (see sections 4.2, 4.4 Haematology, and 4.8).
Croatian: Bolesnike treba pažljivo nadzirati radi ranih manifestacija ozbiljne gastrointestinalne toksičnosti (vidjeti dijelove 4.2, 4.4 Hematologija i 4.8).
English: Docetaxel has been shown to be both embryotoxic and foetotoxic in rabbits and rats, and to reduce fertility in rats.
Croatian: Docetaksel je pokazao embriotoksičnost i fetotoksičnost u kunića i štakora, kao i smanjenje plodnosti u štakora.
English: Exploratory subgroup analyses for disease-free survival for patients who meet the 2009 St. Gallen chemotherapy criteria - (ITT population) were performed and presented here below:
Croatian: Provedene su eksploracijske analize preživljenja bez znakova bolesti u podskupini bolesnika koji zadovoljavaju kriterije za kemoterapiju po kriterijima iz St.Gallena, 2009. (ITT populacija) - rezultati su prikazani u sljedećoj tablici:
English: • Time to progression (TTP) was significantly longer in the AT arm versus AC arm, p = 0.0138.
Croatian: • Vrijeme do progresije bolesti (TTP) bilo je značajno dulje u AT skupini naspram AC skupine, p=0,0138.
English: Mean values for total body clearance and steady-state volume of distribution were 21 l/h/m2 and 113 l, respectively.
Croatian: Srednje vrijednosti ukupnog klirensa i volumena distribucije u stanju dinamičke ravnoteže bile su 21 l/h/ m2 odnosno 113 l.
English: Nervous system The development of severe peripheral neurotoxicity requires a reduction of dose (see section 4.2).
Croatian: Živčani sustav Razvoj teške periferne neurotoksičnosti zahtijeva smanjenje doze (vidjeti dio 4.2).
English: Clear glass (type I) vial with a chlorobutyl rubber stopper and an aluminium seal with a flip-off cap.
Croatian: Prozirna staklena bočica (staklo tip I) s klorobutilnim gumenim čepom i aluminijskim zatvaračem s „flip-off” kapicom.
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the label of the vial after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i naljepnici bočice iza oznake „Rok valjanosti“/EXP.
English: You may experience side effects of this medicine that may impair your ability to drive, use tools or operate machines (see section 4 Possible side effects).
Croatian: Mogu Vam se javiti nuspojave ovog lijeka koje mogu smanjiti Vašu sposobnost upravljanja vozilima, korištenja alata ili upravljanja strojevima (pogledajte dio 4. Moguće nuspojave).
English: If the vials are stored under refrigeration, allow the required number of boxes of Taxespira concentrate for solution for infusion to stand below 25°C for 5 minutes before use.
Croatian: Ako se bočice čuvaju u hladnjaku, izvadite potreban broj kutija Taxespira koncentrata za otopinu za infuziju iz hladnjaka i ostavite ih na temperaturi ispod 25°C 5 minuta prije primjene.
English: Docetaxel infusion solution is supersaturated, therefore may crystallize over time.
Croatian: Otopina docetaksela za infuziju je prezasićena, stoga tijekom vremena može kristalizirati.
English: For combination with trastuzumab, adverse events (all grades) reported in ≥10% are displayed.
Croatian: Za kombinaciju s trastuzumabom prikazane su nuspojave (svi stupnjevi) zabilježene u ≥ 10% bolesnika.
English: The final analysis was performed when all patients had reached their 10-year follow-up visit (unless they had a DFS event or were lost to follow-up before).
Croatian: Konačna analiza provedena je nakon što su svi bolesnici dosegli 10 godina praćenja (osim ako ranije nisu imali DFS događaj ili su ranije prestali biti praćeni).
English: There was less use of morphinic analgesic (p <0.01), non-morphinic analgesics (p <0.01), other disease-related medicinal products (p = 0.06) and radiotherapy (p <0.01) in patients treated with docetaxel at 75 mg/m² compared to those with BSC.
Croatian: Manje su se davali morfinski analgetici (p<0,01), ne-morfinski analgetici (p<0,01), ostali lijekovi povezani s bolesti (p=0,06) i radioterapija (p<0,01) bolesnicima koji su se liječili docetakselom 75 mg/m2 nego onima iz skupine BSC.
English: The median TTP was 37.3 weeks (95% CI: 33.4 - 42.1) in AT arm and 31.9 weeks (95% CI:
Croatian: Medijan TTP bio je 37,3 tjedna (95% CI: 33,4-42,1) u AT skupini i 31,9 tjedna (95% CI: 27,4-36,0) u AC skupini.
English: The survival rate was 93.7% in the TAC arm and 91.4 % in the FAC arm, at the 8-year follow-up timepoint, and 91.3 % in the TAC arm and 89 % in the FAC arm, at the 10-year follow-up timepoint.
Croatian: Stopa preživljenja bila je 93,7% u TAC skupini i 91,4% u FAC skupini, u točki praćenja od 8 godina te 91,3% u TAC skupini i 89% u FAC skupini, u točki praćenja od 10 godina.
English: Note that this is likely to be an underestimate since docetaxel alone at a dose of 100 mg/m2 is known to result in neutropenia in 97% of patients, 76% grade 4, based on nadir blood counts.
Croatian: Treba uzeti u obzir da su ti podaci vjerojatno podcijenjeni jer je poznato da monoterapija docetakselom u dozi od 100 mg/m uzrokuje neutropeniju u 97% bolesnika, u 76% stupnja 4, baziranu na najnižim vrijednostima broja krvnih stanica.
English: Vascular disorders Venous thromboembolic events have rarely been reported.
Croatian: Rijetko su zabilježeni venski tromboembolički događaji.
English: In patients treated with the TAC regimen for node positive breast cancer, the risk of CHF has been shown to be higher during the first year after treatment (see sections 4.8 and 5.1).
Croatian: U bolesnika liječenih TAC režimom zbog karcinoma dojke s pozitivnim limfnim čvorovima, pokazalo se da je rizik od kongestivnog srčanog zatajenja veći tijekom prve godine nakon liječenja (vidjeti dijelove 4.8 i 5.1).
English: Patients treated with TCF had a longer time to 5% definitive deterioration of global health status on the QLQ-C30 questionnaire (p = 0.0121) and a longer time to definitive worsening of Karnofsky performance status (p = 0.0088) compared to patients treated with CF.
Croatian: Bolesnici liječeni s TCF imali su do 5% dulje vrijeme do definitivnog pogoršanja zdravstvenog statusa prema upitniku QLQ-C30 (p=0,0121) i dulje vrijeme do definitivnog pogoršanja prema Karnofski izvedbenom statusu (p=0,0088) u usporedbi s bolesnicima liječenim s CF.
English: Febrile neutropenia
Croatian: febrilna neutropenija
English: The combined administration of docetaxel, cisplatin and 5-fluorouracil in 12 patients with solid tumours had no influence on the pharmacokinetics of each individual medicinal product.
Croatian: Kombinirana primjena docetaksela, cisplatina i 5-fluoruracila u 12 bolesnika sa solidnim tumorima nije utjecala na pojedinačnu farmakokinetiku tih lijekova.
English: TAC = docetaxel, doxorubicin and cyclophosphamide FAC = 5-fluorouracil, doxorubicin and cyclophosphamide CI = confidence interval; ER = estrogen receptor PR = progesterone receptor
Croatian: TAC = docetaksel, doksorubicin i ciklofosfamid FAC = 5-fluorouracil, doksorubicin i ciklofosfamid CI = interval pouzdanost; ER = estrogenski receptor PR = progesteronski receptor ER/PR-negativni ili gradus 3 ili veličina tumora >5 cm