FrancophonIA/ELRC3.0 huggingface dataset:
English: Medical history and regular check-ups
Croatian: Povijest bolesti i redoviti pregledi
English: If you have any unexpected vaginal bleeding, you must contact your doctor as soon as possible.
Croatian: Ako imate neočekivano vaginalno krvarenje, morate se odmah obratiti liječniku.
English: For initiation and continuation of treatment of postmenopausal symptoms, the lowest effective dose for the shortest duration should be used (see section 4.4).
Croatian: Za početak i nastavak liječenja postmenopauzalnih simptoma mora se uzimati najniža učinkovita doza tijekom najkraćeg razdoblja (vidjeti dio 4.4).
English: The concentrations of this glucuronide are approximately 10-fold higher than those of unchanged BZA in plasma.
Croatian: Koncentracija ovog glukuronida je otprilike 10 puta veća od nepromijenjene BZA u plazmi.
English: If this happens, you should avoid driving or operating machines until your doctor tells you that it is safe to do so.
Croatian: Ako Vam se to dogodi, izbjegavajte voziti ili upravljati strojevima dok Vam liječnik ne kaže da je sigurno to činiti.
English: This may include an examination of your breasts and/or an internal examination, if necessary, or if you have any special concerns.
Croatian: To može uključiti pregled dojki i/ili pregled unutarnjih organa, ako je potrebno ili ako ste posebno zabrinuti zbog nečega.
English: • Changes in mood
Croatian: • Promjene raspoloženja
English: If you forget to take a tablet, take it as soon as you remember.
Croatian: Ako zaboravite uzeti tabletu, uzmite je čim se sjetite.
English: See your doctor as soon as possible if you notice any changes, such as:
Croatian: Odmah se obratite liječniku ako uočite promjene kao što su:
English: As in all postoperative patients, prophylactic measures need be considered to prevent VTE following surgery.
Croatian: Kao i u svih bolesnika u poslijeoperativnom razdoblju, treba razmotriti profilaktičke mjere kako bi se spriječila VTE nakon operacije.
English: The major route of excretion of radiolabeled BZA is the faeces, and less than 1% of the dose is eliminated in urine.
Croatian: Glavni put izlučivanja radioaktivno obilježene BZA je putem stolice, a manje od 1% doze eliminira se urinom.
English: You may also have ulcers in the mouth, eyes or genitals and have a fever
Croatian: Također možete dobiti ulceracije u ustima, očima ili vanjskim spolnim organima te dobiti vrućicu
English: DUAVIVE alleviates these symptoms after menopause.
Croatian: DUAVIVE ublažava ove simptome nakon menopauze.
English: Date of first authorisation: 16 December 2014 Date of latest renewal:
Croatian: Datum prvog odobrenja: 16. prosinca 2014.
English: Food had little or no effect on the exposure of CE.
Croatian: Hrana je imala mali ili nije imala uopće utjecaj na izloženost KE.
English: DUAVIVE and your heart or circulation
Croatian: DUAVIVE i srce ili cirkulacija
English: These findings are considered rat-specific and presumably not relevant in humans.
Croatian: Smatra se da su ovi nalazi specifični za štakore i da vjerojatno nisu značajni za ljude.
English: Oestrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organs.
Croatian: Estrogeni se široko distribuiraju u tijelu i općenito su nađeni u većim koncentracijama u ciljnim organima za spolne hormone.
English: Dementia; depression; mood altered; changes in libido
Croatian: Demencija; depresija; promjene raspoloženja; promjene libida
English: However, if it is almost time to take your next tablet, skip the tablet you missed and only take your next scheduled tablet.
Croatian: Međutim, ako je vrijeme za uzimanje sljedeće tablete, preskočite tabletu koju ste zaboravili te uzmite samo predviđenu sljedeću tabletu.
English: Before initiating or reinstituting treatment with CE/BZA, a complete personal and family medical history should be taken.
Croatian: Prije početka ili ponovnog liječenja KE/BZA-om mora se uzeti potpuna osobna i obiteljska anamneza.
English: Investigations, including appropriate imaging tools, e.g., mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual.
Croatian: Pretrage, uključujući odgovarajuće metode oslikavanja, npr. mamografiju, treba provoditi u skladu s trenutno prihvaćenim načelima probira, prilagođenim kliničkim potrebama svake pojedine osobe.
English: Tablets should be swallowed whole.
Croatian: Tablete treba progutati cijele.
English: What DUAVIVE contains
Croatian: Što DUAVIVE sadrži
English: What you need to know before you take DUAVIVE
Croatian: Što morate znati prije nego počnete uzimati DUAVIVE
English: There is no evidence that HRT will prevent a heart attack.
Croatian: Nema dokaza da HNL sprječava srčani udar.
English: It should be taken into account that these conditions may recur or be aggravated during treatment with CE/BZA, in particular:
Croatian: Treba voditi računa o tome da se ova stanja mogu ponovno pojaviti ili pogoršati tijekom liječenja KE/BZA-om, a to se osobito odnosi na:
English: • if any of your close relatives has ever had a blood clot in the leg, lung or another organ
Croatian: • ako je bilo tko od Vaše bliže rodbine imao krvni ugrušak u nozi, plućima ili drugim organima
English: If you take too many tablets you may have nausea (feel sick) or vomit.
Croatian: Ako uzmete previše tableta možete osjećati mučninu ili povraćati.
English: If you take more DUAVIVE than you should
Croatian: Ako uzmete više lijeka DUAVIVE nego što ste trebali
English: Following intravenous administration of a 3 mg dose of BZA alone, the volume of distribution is 14.7 3.9 l/kg.
Croatian: Nakon intravenske primjene doze od 3 mg same BZA, volumen distribucije je 14,7  3,9 l/kg.
English: Annual monitoring of serum triglyceride levels should therefore be considered.
Croatian: Potrebno je stoga razmotriti godišnje praćenje razina triglicerida u serumu.
English: These substitute for the loss of oestrogen production in menopausal women, and alleviate menopausal symptoms.
Croatian: Oni zamjenjuju gubitak proizvodnje estrogena kod žena u menopauzi i ublažavaju menopauzalne simptome.
English: CE/BZA may be taken at any time of day, without regard to meals (see section 5.2).
Croatian: KE/BZA se može uzeti u bilo koje doba dana, bez obzira na obroke (vidjeti dio 5.2).
English: • An effect on the way in which your blood sugar (glucose) levels are controlled including increased glucose levels in the blood
Croatian: • Utjecaj na način na koji se kontroliraju razine šećera (glukoze) u krvi uključujući povećanu razinu glukoze u krvi
English: Intolerance to contact lenses
Croatian: Intolerancija na kontaktne leće
English: This increase is most likely attributable to age-related changes in hepatic function.
Croatian: To povećanje se najvjerojatnije može pripisati promjenama funkcije jetre koje su povezane s dobi.
English: • Increases in liver enzymes (identified in routine liver function testing)
Croatian: • Povišene vrijednosti jetrenih enzima (utvrđene rutinskim testom funkcije jetre)
English: • if you have any blood clotting problem that needs long-term treatment with a medicine used to prevent blood clots
Croatian: • ako imate problem sa zgrušavanjem krvi kojeg treba dugotrajno liječiti lijekom koji se koristi u sprječavanju nastanka krvnih ugrušaka
English: Circulating oestrogens exist in a dynamic equilibrium of metabolic interconversions.
Croatian: Cirkulirajući estrogeni postoje u stanju dinamičke ravnoteže metaboličke međupretvorbe.
English: Heart disease (heart attack)
Croatian: Bolest srca (srčani udar)
English: CE/BZA has not been studied in women with baseline triglyceride levels >300 mg/dL (>3.4 mmol/L).
Croatian: KE/BZA nije ispitivan u žena u kojih je početna razina triglicerida >300 mg/dl (>3,4 mmol/l).
English: • Blood clot in a vein at the back of the eye (retinal vein) which may lead to loss of vision
Croatian: • Krvni ugrušak u veni u stražnjem dijelu oka (retinalnoj veni) koji može dovesti do gubitka vida
English: Glucuronidation is the major metabolic pathway.
Croatian: Glukuronidacija je glavni metabolički put.
English: The clearance of BZA is 0.4 ±0.1 L/h/kg based on intravenous administration.
Croatian: Klirens BZA je 0,4 ± 0,1 l/h/kg na temelju intravenske primjene.
English: If you are going to have surgery, tell the surgeon you are taking DUAVIVE.
Croatian: Ako ćete se podvrgnuti kirurškom zahvatu, obavijestite kirurga da uzimate lijek DUAVIVE.
English: • Memory loss (dementia)
Croatian: • Gubitak pamćenja (demencija)
English: 17β-estradiol is converted reversibly to estrone, and both can be converted to estriol, which is the major urinary metabolite.
Croatian: 17βestradiol se reverzibilno konvertira u estron, a oba mogu biti konvertirana u estriol, koji je glavni urinarni metabolit.
English: Ritonavir and nelfinavir, although known as strong inhibitors, by contrast exhibit inducing properties when used concomitantly with steroid hormones.
Croatian: Ritonavir i nelfinavir, iako poznati kao snažni inhibitori, suprotno tome pokazuju inducirajuća svojstva kada se koriste istodobno sa steroidnim hormonima.
English: If prolonged immobilisation is to follow elective surgery temporarily stopping CE/BZA 4 to 6 weeks earlier is recommended.
Croatian: Kad se nakon elektivnog operativnog zahvata očekuje produljena imobilizacija, preporučeno je privremeno prekinuti uzimanje KE/BZA 4 do 6 tjedana prije.
English: Erythema multiforme; erythema nodosum
Croatian: Multiformni eritem; nodozni eritem
English: If you stop taking DUAVIVE
Croatian: Ako prestanete uzimati DUAVIVE
English: Based on available data no dosage adjustment is necessary based on age (see section 5.2).
Croatian: Na temelju dostupnih podataka nije potrebna prilagodba doze zbog dobi (vidjeti dio 5.2).
English: Do not store above 25ºC.
Croatian: Ne čuvati na temperaturi iznad 25ºC.
English: Age range (years)
Croatian: Dobni raspon (godine)
English: The risk ratio is not constant but will increase with increasing duration on use.
Croatian: Omjer rizika nije konstantan već će se povećati uz produljeno trajanje liječenja.
English: The additive effect of all sources of sorbitol from other concomitantly administered medicinal products and dietary sources should be taken into account.
Croatian: Potrebno je uzeti u obzir aditivni učinak svih izvora sorbitola iz drugih istodobno primijenjenih lijekova i prehrane.
English: This medicine contains 0.0088 mg sorbitol in each tablet.
Croatian: Ovaj lijek sadrži 0,0088 mg sorbitola u jednoj tableti.
English: Stop taking DUAVIVE and see a doctor immediately if you get any of the following serious side effects:
Croatian: Prestanite uzimati DUAVIVE te se odmah obratite liječniku ako dobijete bilo koju od sljedećih ozbiljnih nuspojava:
English: • Low levels of blood calcium (hypocalcaemia); frequently there will be no symptoms to suggest that your blood calcium is low, but when hypocalcaemia is severe you may feel tired, generally unwell, depressed and become dehydrated.
Croatian: • Niske razine kalcija u krvi (hipokalcemija); često nema simptoma koji ukazuju da je razina kalcija u krvi niska, ali kod težeg oblika hipokalcemije možete se osjećati umorno, općenito loše, depresivno i možete postati dehidrirani.
English: During these check-ups, discuss with your doctor the benefits and risks of continuing with DUAVIVE.
Croatian: Tijekom pregleda porazgovarajte sa svojim liječnikom o koristima i rizicima daljnjeg uzimanja lijeka DUAVIVE.
English: After opening the blister pouch, use within 60 days.
Croatian: Nakon otvaranja vrećice s blisterom, upotrijebiti unutar 60 dana.
English: This can cause symptoms such as hot face, neck and chest ("hot flushes").
Croatian: To može uzrokovati simptome kao što su vrućina u licu, vratu i prsima („valunzi”).
English: No foetal developmental anomalies were observed.
Croatian: Nisu opažene anomalije u razvoju fetusa.
English: The European Medicines Agency has waived the obligation to submit the results of studies with CE/BZA in all subsets of the paediatric population in the ‘treatment of oestrogen deficiency symptoms in postmenopausal women' (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja s KE/BZA-om u svim podskupinama pedijatrijske populacije za „liječenje simptoma nedostatka estrogena u postmenopauzalnih žena“ (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: On average, women with hepatic impairment showed a 4.3-fold increase in AUC compared with controls.
Croatian: U prosjeku, žene s oštećenjem funkcije jetre pokazale su 4,3 puta veći AUC u usporedbi s kontrolnom skupinom.
English: If you decide to stop taking this medicine before finishing the prescribed course of treatment, you should talk to your doctor first.
Croatian: Ako odlučite prestati uzimati ovaj lijek prije završetka propisane terapije, porazgovarajte prvo sa svojim liječnikom.
English: Blood triglycerides increased, alanine aminotransferase increased; aspartate aminotransferase increased
Croatian: Povišeni trigliceridi u krvi, povišena alanin aminotransferaza; povišena aspartat aminotransferaza
English: - Acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal.
Croatian: - Akutna bolest jetre ili bolest jetre u anamnezi, sve dok se testovi funkcije jetre ne vrate na normalu.
English: Exacerbation of porphyria; hypocalcaemia (in patients with disease that can predispose to severe hypocalcaemia)
Croatian: Pogoršanje porfirije; hipokalcemija (u bolesnica s bolestima koje mogu pogodovati teškoj hipokalcemiji)
English: Uncommon: may affect 1 in 100 people • If you begin to get migraine-like headaches, or severe headaches
Croatian: Manje česte: mogu se javiti u do 1 na 100 osoba • Ako Vam se počnu javljati glavobolje nalik migreni ili jake glavobolje
English: The results of most epidemiological studies to date relevant to inadvertent foetal exposure to oestrogens indicate no teratogenic or foetotoxic effects.
Croatian: Rezultati većine dosadašnjih epidemioloških ispitivanja relevantnih za nenamjernu izloženost fetusa estrogenima nisu ukazali na teratogeni ili fetotoksični učinak.
English: - Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivost na djelatne tvari ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: Longterm exposure to CE/BZA for up to 2 years was evaluated; 3,322 women were exposed to CE/BZA for at least 1 year, and 1,999 women were exposed for 2 years.
Croatian: Ispitivano je dugotrajno izlaganje KE/BZA-u do 2 godine; 3322 žene bile su izložene KE/BZA-u najmanje 1 godinu, a 1999 žena bilo je izloženo 2 godine.
English: This medicinal product contains sorbitol which may affect the bioavailability of other concomitantly administered medicinal products.
Croatian: Ovaj lijek sadrži sorbitol koji može utjecati na bioraspoloživost drugih istodobno primijenjenih lijekova.
English: The most commonly reported adverse reaction is abdominal pain, occurring in more than 10% of patients in clinical trials.
Croatian: Najčešće prijavljena nuspojava bila je bol u trbuhu, opažena u više od 10% bolesnica u kliničkim ispitivanjima.
English: • A worsening of chorea (an existing neurological disorder characterised by involuntary spasmodic movements of the body)
Croatian: • Pogoršanje koreje (postojeći neurološki poremećaj kojeg karakteriziraju nevoljni spazmodični pokreti tijela)
English: If such symptoms occur, patients should avoid driving or use of machines that requires accurate visual perception until symptoms have resolved, or until they have received medical advice that it is safe to do so.
Croatian: Ako se ti simptomi pojave, bolesnice ne bi smjele voziti niti raditi sa strojevima za koje je neophodna precizna vizualna percepcija dok se simptomi ne povuku ili dok ne dobiju liječnički savjet da je to sigurno.
English: CE/BZA was evaluated in 4,868 post-menopausal women who participated in 5 phase 3 trials.
Croatian: KE/BZA je ispitivan u 4868 postmenopauzalnih žena koje su sudjelovale u pet kliničkih ispitivanja faze 3.
English: Coronary artery disease (CAD)
Croatian: Koronarna arterijska bolest (KAB)
English: Estradiol only
Croatian: Samo estradiol
English: This medicine is for use only by postmenopausal women.
Croatian: Ovaj lijek je namijenjen isključivo za liječenje postmenopauzalnih žena.
English: The level of risk is dependent on duration of use (see section 4.4).
Croatian: Razina rizika ovisi o trajanju primjene (vidjeti dio 4.4).
English: The occurrence of such an event is more likely in the first year of HRT than later (see section 4.8).
Croatian: Pojavnost takvog događaja vjerojatnija je u prvoj godini hormonskog nadomjesnog liječenja (HNL) nego kasnije (vidjeti dio 4.8).
English: These tumours are known to occur in aged nonhuman primates and were considered spontaneous in the aged monkeys and irrelevant to humans.
Croatian: Poznato je da se navedeni tumori pojavljuju u starijih životinja primata i smatrali su se spontanima u starijih majmuna te nevažnima za ljude.
English: - Undiagnosed genital bleeding.
Croatian: Nedijagnosticirano genitalno krvarenje.
English: Adverse reactions were categorised as very common ( 1/10), common ( 1/100 to < 1/10), uncommon ( 1/1,000 to < 1/100), rare ( 1/10,000 to < 1/1,000), very rare (< 1/10,000) or not known (cannot be estimated from available data).
Croatian: Nuspojave su kategorizirane kao vrlo često ( 1/10), često ( 1/100 i < 1/10), manje često ( 1/1000 i < 1/100), rijetko ( 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000) ili nepoznato (ne može se procijeniti iz dostupnih podataka).
English: *no differentiation was made between ischaemic and haemorrhagic stroke.
Croatian: *Nije bilo razlika između ishemijskog i hemoragijskog moždanog udara.
English: Oestrogen therapy use does not improve cognitive function.
Croatian: Primjena terapije estrogenom ne poboljšava kognitivnu funkciju.
English: If you forget to take DUAVIVE
Croatian: Ako zaboravite uzeti DUAVIVE
English: Increases in blood pressure
Croatian: Porast krvnog tlaka
English: On average, compared to women 51 to 64 years of age (n=8), women 65 to 74 years of age (n=8) showed a 1.5-fold increase in AUC, and women 75 years of age (n=8) showed a 2.6-fold increase in AUC.
Croatian: U prosjeku, u usporedbi sa ženama u dobi od 51 do 64 godine (n=8), u žena u dobi od 65 do 74 godine (n=8) opažen je 1,5 puta veći AUC, a u žena dobi 75 godina (n=8) opažen je 2,6 puta veći AUC.
English: Physical (including pelvic and breast) examination should be guided by this and by the contraindications and precautions for use.
Croatian: Fizikalni pregled (koji uključuje pregled zdjelice i dojki) treba provoditi vodeći računa o ovome, kao i o kontraindikacijama i mjerama opreza za uporabu.
English: Vulvovaginal candidiasis
Croatian: Vulvovaginalna kandidijaza
English: Depending on the duration of oestrogen-only use and oestrogen dose, the increase in risk of endometrial cancer in epidemiology studies varied from 5 to 55 extra cases diagnosed in every 1,000 women between the ages of 50 and 65 years.
Croatian: Ovisno o trajanju primjene samog estrogena i o dozi estrogena, povećanje rizika od raka endometrija u epidemiološkim ispitivanjima kretalo se od 5 do 55 dodatnih slučajeva na svakih 1000 žena u dobi od 50 do 65 godina.
English: • Painful red bumps on the skin
Croatian: • Bolne crvene kvržice na koži
English: Pharmacokinetic studies for CE/BZA were conducted in healthy postmenopausal women who were naturally postmenopausal or who had undergone bilateral oophorectomy.
Croatian: Farmakokinetička ispitivanja KE/BZA-a provedena su u zdravih posmtenopauzalnih žena koje su prirodno u postmenopauzi ili koje su prošle bilateralnu ooforektomiju.
English: No studies were performed on animals to evaluate the effects on reproduction with the CE/BZA combination.
Croatian: Nisu provedena ispitivanja na životinjama s ciljem procjene učinka kombinacije KE/BZA na reprodukciju.
English: There are no data from the use of CE/BZA in pregnant women.
Croatian: Nema podataka o primjeni KE/BZA u trudnica.
English: You should continue taking this medicine for as long as your doctor tells you.
Croatian: Nastavite uzimati ovaj lijek onoliko dugo koliko Vam kaže liječnik.
English: The additional risk of ischaemic stroke over five years of use was assessed in the largest randomised trial in women without a uterus (WHI) from 50-59 years of age.
Croatian: Dodatni rizik od ishemijskog moždanog udara tijekom pet godina primjene procijenjen je u najvećem randomiziranom ispitivanju u žena bez maternice (WHI) u dobi od 50 do 59 godina.
English: Exacerbation of epilepsy
Croatian: Pogoršanje epilepsije
English: In postmenopausal women, a significant proportion of the circulating oestrogens exists as sulfate conjugates, especially estrone sulfate, which serves as a circulating reservoir for the formation of more active oestrogens.
Croatian: U postmenopauzalnih žena značajan dio cirkulirajućih estrogena nalazi se u obliku sulfatnih konjugata, posebice estron sulfata, koji služi kao cirkulirajući spremnik za stvaranje aktivnijih estrogena.
English: • Feeling nervous
Croatian: • Osjećaj nervoze
English: Change in cervical ectropion and secretion
Croatian: Promjene u cervikalnoj ektropiji i sekreciji
English: Relief of symptoms occurring after menopause
Croatian: Ublažavanje simptoma koji nastaju nakon menopauze
English: - Jaundice or deterioration in liver function - Significant increase in blood pressure -New onset of migraine-type headache
Croatian: žutica ili pogoršanje funkcije jetre značajan porast krvnog tlaka nova pojava glavobolje migrenskog tipa
English: Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1 antitrypsin, ceruloplasmin).
Croatian: Ostali proteini plazme mogu biti povišeni (supstrat angiotenzinogen/renin, alfa-1 antitripsin, ceruloplazmin).
English: • Palpitations (awareness of your heart beat)
Croatian: • Palpitacije (svjesnost otkucaja srca)
English: • Depression
Croatian: • Depresija
English: Bazedoxifene-5-glucuronide is the major circulating metabolite.
Croatian: Bazedoksifen 5-glukuronid je glavni cirkulirajući metabolit.
English: Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgium.
Croatian: Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgija.
English: In clinical trials of up to 2 years duration in postmenopausal women with CE/BZA, cases of VTE have been reported (see section 4.8).
Croatian: U kliničkim ispitivanjima u trajanju do 2 godine u postmenopauzalnih žena s KE/BZA zabilježeni su slučajevi VTE (vidjeti dio 4.8).
English: DUAVIVE is indicated for the treatment of oestrogen deficiency symptoms in postmenopausal women with a uterus (with at least 12 months since the last menses) for whom treatment with progestin-containing therapy is not appropriate.
Croatian: DUAVIVE je indiciran za liječenje simptoma nedostatka estrogena u postmenopauzalnih žena s maternicom (kod kojih je proteklo najmanje 12 mjeseci od zadnje menstruacije) kod kojih nije prikladno liječenje terapijom koja sadrži progestin.
English: • Alopecia (hair loss)
Croatian: • Alopecija (gubitak kose)
English: In vitro and in vivo studies have shown that oestrogens are partially metabolised by cytochrome P450 enzymes, including CYP3A4.
Croatian: In vitro i in vivo ispitivanja pokazala su da se estrogeni jednim dijelom metaboliziraju enzimima citokroma P450 uključujući CYP3A4.
English: BZA is highly bound (98% - 99%) to plasma proteins in vitro, but does not bind to sex hormone binding globulin (SHBG).
Croatian: BZA se u visokom postotku veže (98%-99%) za proteine u plazmi in vitro, ali se ne vezuje za globulin koji veže spolne hormone.
English: DUAVIVE (CE/BZA) has not been studied in the treatment of premature menopause.
Croatian: DUAVIVE (KE/BZA) nije ispitan za liječenje preuranjene menopauze.
English: BZA is extensively metabolised in women.
Croatian: BZA se u velikoj mjeri metabolizira u žena.