FrancophonIA/ELRC3.0 huggingface dataset:
English: i) adverse cognitive outcomes ii) adverse psychiatric outcomes (e.g. mood disorders, hostility and psychotic disorders)
Slovenian: i) neželeni kognitivni izidi ii) neželeni psihiatrični izidi (npr. motnje razpoloženja, sovražnost in psihotične motnje)
English: Fatigue Methylphenidate should not be used for the prevention or treatment of normal fatigue states.
Slovenian: Utrujenost Metilfenidata ne smete uporabljati za preprečevanje ali zdravljenje normalnih stanj utrujenosti.
English: LV - Latvia Novartis Finland Oy, Metsanneidonkuja 10, , FI-02130 Espoo, Finland,
Slovenian: LV - Latvija Novartis Finland Oy, Metsanneidonkuja 10, , FI-02130 Espoo, Finland,
English: Following the discussions at the CHMP it was agreed that long-term use data is still needed on a potential effect of methylphenidate on cardiovascular and cerebrovascular events.
Slovenian: CHMP se je po razpravi strinjal, da so še vedno potrebni podatki o dolgoročni uporabi glede potencialnega učinka metilfenidata na srčno-žilne in cerebrovaskularne dogodke.
English: Although the study focuses on smoking prevention, Tanner staging examinations will occur every 6 months during the 2-year follow-up and will monitor each subject's pubertal development to demonstrate whether methylphenidate has any effect on adolescent growth and development compared to population norms.
Slovenian: Čeprav se študija osredotoča na preprečevanje kajenja, se v dveletnem obdobju sledenja vsakih 6 mesecev opravi preiskava z ocenjevanjem po Tannerju ter se spremlja pubertetni razvoj vsakega preiskovanca, da bi ugotovili, ali metilfenidat vpliva na rast in razvoj mladostnikov v primerjavi z normami populacije.
English: The safety of using methylphenidate in combination with clonidine or other centrally acting alpha-2 agonists has not been systematically evaluated.
Slovenian: Varnost uporabe metilfenidata v kombinaciji s klonidinom ali drugimi centralno delujočimi agonisti adrenergičnih receptorjev alfa-2 še niso sistematsko ovrednotili.
English: Aside from the issue of growth, there is lack of adequate clinical or pharmacoepidemiological data on the effects of long-term treatment with methylphenidate in the EU, in relation to cardiovascular, cerebrovascular, psychiatric, carcinogenicity or any other long-term risks.
Slovenian: Poleg vprašanja rasti manjkajo zadostni klinični ali farmakoepidemiološki podatki o učinkih dolgoročnega zdravljenja z metilfenidatom v EU v zvezi s tveganjem srčno-žilnih obolenj, cerebrovaskularnih obolenj, psihiatričnih motenj, karcinogenosti ter drugimi dolgoročnimi tveganji.
English: IE - Ireland Ratiopharm GmbH, Graf-Arco-Strasse 3, D
Slovenian: Ratiopharm GmbH, Graf-Arco-Strasse 3, D
English: • Diagnosis or history of severe and episodic (Type I) Bipolar (affective) Disorder (that is not wellcontrolled)
Slovenian: • diagnoza ali anamneza hude ali epizodne bipolarne (afektivne) motnje (tipa I), ki ni dobro nadzorovana
English: Additionally, there was some preclinical evidence of a direct effect of methylphenidate on the structure of cardiac tissue.
Slovenian: Poleg tega je bilo nekaj predkliničnih dokazov o neposrednem učinku metilfenidata na strukturo srčnega tkiva.
English: - pregnant or think you may be pregnant.
Slovenian: Zdravnik vam bo svetoval glede kontracepcije; - noseči ali mislite, da bi lahko bili noseči.
English: {For inclusion in the PL of non-modified release formulations of methylphenidate:} “Taking methylphenidate with food and drink Taking methylphenidate with food may help relieve stomach pains, feeling sick or vomitting.”
Slovenian: {Za vključitev v navodilo za uporabo nespremenjenih formulacij za sproščanje metilfenidata:} „Jemanje metilfenidata skupaj s hrano in pijačo Jemanje metilfenidata s hrano lahko pomaga ublažiti bolečine v želodcu, občutke slabosti ali bruhanje.“
English: - The Committee, considered the benefit/risk balance of medicinal products containing methylphenidate in the treatment of ADHD in children aged 6 years and over and in adolescents in the EU.
Slovenian: - Odbor je upošteval razmerje med koristnimi učinki in tveganji za zdravila, ki vsebujejo metilfenidat, za zdravljenje motnje ADHD pri otrocih, starih 6 let in več, in pri mladostnikih v EU.
English: The MAHs committed to provide a detailed feasibility assessment for a scientifically valid, welldesigned and suitably powered long-term safety study to examine specific endpoints for the following outcomes:
Slovenian: Imetniki dovoljenj za promet z zdravilom so se zavezali k izvedbi podrobnega vrednotenja izvedljivosti znanstveno veljavne, dobro zasnovane in primerno močne študije dolgoročne varnosti, v kateri bi pregledali specifične končne točne naslednjih izidov:
English: In addition the results of the ongoing study on suicidality will be submitted once available and the MAHs undertook the commitment to investigate psychiatric outcomes in a future long-term study.
Slovenian: Poleg tega bodo, ko bodo na voljo, predloženi rezultati tekoče študije o samomorilnosti, imetniki dovoljenj za promet z zdravilom pa so se zavezali, da bodo raziskali psihiatrične izide v prihodnji dolgoročni študiji.
English: Fax: +30-210-6140072
Slovenian: Telefaks: +30-210-6140072
English: Review of the pre-clinical data in the responses shows that methylphenidate causes behavioural changes in animal models, mainly as hyperactivity and stereotyped behaviour.
Slovenian: Pregled predkliničnih podatkov v odzivih kaže, da metilfenidat povzroča spremembe vedenja pri živalskih modelih, zlasti hiperaktivnost ter stereotipno vedenje.
English: However, a sympathetomimetic effect on the cardiovascular system was considered plausible.
Slovenian: Vendar se za možnega šteje simpatikomimetični učinek na srčno-žilni sistem.
English: • whether there is a family history of tics
Slovenian: • o morebitni družinski anamnezi tikov.
English: These will include:
Slovenian: Ob upoštevanju naslednjega:
English: Long-term treatment
Slovenian: Dolgoročno zdravljenje
English: Long Term Use effects
Slovenian: Učinki zaradi dolgoročne uporabe
English: FR - France NOVARTIS PHARMA SAS 2-4 rue Lionel Terray
Slovenian: FR - Francija NOVARTIS PHARMA SAS 2-4 rue Lionel Terray
English: Use with halogenated anaesthetics
Slovenian: Uporaba s halogeniranimi anestetiki
English: HU - Hungary Novartis Hungária Kft.Pharma 1114 Budapest
Slovenian: Novartis Hungária Kft.Pharma 1114 Budapest
English: In life-time rat and mouse carcinogenicity studies, increased numbers of malignant liver tumours were noted in male mice only.
Slovenian: V življenjskih študijah kancerogenosti na podganah in miših, so samo pri mišjih samicah opazili povečano število malignih jetrnih tumorjev.
English: Pregnancy There is a limited amount of data from the use of methylphenidate in pregnant women.
Slovenian: Nosečnost Na voljo je le malo podatkov o uporabi metilfenidata pri nosečnicah.
English: Very common (more than 1 out of 10 persons) Common (more than 1 out of 100 persons and less than 1 out of 10 persons) Uncommon (more than 1 out of 1,000 persons and less than 1 out of 100 persons) Rare (more than 1 out of 10,000 persons and less than 1 out of 1,000 persons) Very rare (less than 1 out of 10,000 persons) Not known (cannot be estimated from the available data).
Slovenian: Zelo pogosti (pri več kot 1 osebi od 10) Pogosti(pri več kot 1 osebi od 100 in pri manj kot 1 osebi od 10) Občasni (pri več kot 1 osebi od 1 000 in pri manj kot 1 osebi od 100) Redki (pri več kot 1 osebi od 10 000 in pri manj kot 1 osebi od 1 000)
English: It is important that you provide all information so your doctor can decide if methylphenidate is the correct medicine for you or your child.
Slovenian: Pomembno je, da navedete vse podatke, da se bo lahko zdravnik odločil, ali je metilfenidat pravo zdravilo za vas ali vašega otroka.
English: ES - Spain Laboratorios RUBIO, SA Industria 29- Polígono industrial Comte de Sert
Slovenian: ES - Španija Laboratorios RUBIO, SA Industria 29- Polígono industrial Comte de Sert
English: The MAHs commit to provide all available retrospective data on an annual review basis for the next five years in all Member States where methylphenidate is used, to allow an evaluation of changes in usage over time.
Slovenian: Imetniki dovoljenj za promet z zdravilom so se zavezali, da bodo za letne revizije v obdobju naslednjih petih let predlagali vse razpoložljive retrospektivne podatke iz vseh držav članic, kjer se metilfenidat uporablja, da se bodo ovrednotile spremembe uporabe zdravila s časom.
English: Methylphenidate is not recommended for use during pregnancy unless a clinical decision is made that postponing treatment may pose a greater risk to the pregnancy.
Slovenian: Uporaba metilfenidata med nosečnostjo ni priporočljiva, razen če na osnovi klinične ocene, odložitev zdravljenja predstavlja večje tveganje za nosečnost.
English: The difficulty in determining the effects of methylphenidate in most of the studies due to the co-morbidity between ADHD and psychiatric disorders was also noted.
Slovenian: Ugotovljeno je bilo tudi težavno določanje učinkov metilfenidata v večini študij zaradi sočasnosti ADHD in psihiatričnih motenj.
English: Patients with emergent suicidal ideation or behaviour during treatment for ADHD should be evaluated immediately by their physician.
Slovenian: Bolnike, pri katerih se začnejo pojavljati samomorilne misli ali vedenje med zdravljenjem ADHD, mora nemudoma pregledati njihov zdravnik in oceniti njihovo stanje.
English: FR - France UCB PHARMA S.A. 21 rue de Neuilly
Slovenian: FR - Francija UCB PHARMA S.A. 21 rue de Neuilly
English: Methylphenidate may have some activity as a nongenotoxic carcinogen in mouse liver; however, the limited human analyses do not suggest that this activity is reproduced in humans exposed to therapeutic doses.
Slovenian: Metilfenidat morda ima nekaj aktivnosti kot negenotoksična karcinogena snov v jetrih miši, vendar omejene analize pri človeku ne nakazujejo enake aktivnosti pri človeku, izpostavljenemu terapevtskim odmerkom.
English: 2.6 Effects of long term treatment
Slovenian: 2.6 Učinki dolgoročnega zdravljenja
English: The product information (PI) of most products contains key elements on the above safety concerns of methylphenidate.
Slovenian: Podatki o večini zdravil vsebujejo ključne elemente zgoraj omenjenih varnostnih zadržkov za metilfenidat.
English: The product information for most of the methylphenidate-containing products in the EU contain warnings for use in patients with underlying cardiac disorders and lists many of the disorders reported with cyanosis as possible ADRs in section 4.8.
Slovenian: Podatki o zdravilu za večino zdravil, ki vsebujejo metilfenidat, v EU vsebujejo opozorila glede uporabe pri bolnikih z obstoječimi obolenji srca ter navedbe veliko motenj, ki so bile poročane skupaj s cianozo, kot možnih neželenih učinkov v poglavju 4.8.
English: If paradoxical aggravation of symptoms or other serious adverse events occur, the dosage should be reduced or discontinued.
Slovenian: Če se pojavi paradoksno poslabšanje simptomov ali nastopijo drugi resni neželeni učinki, je treba zmanjšati odmerek zdravila ali prekiniti zdravljenje.
English: The long-term safety of treatment with methylphenidate is not fully known.
Slovenian: Varnost dolgotrajnega zdravljenja z metilfenidatom ni popolnoma pojasnjena.
English: Caution is called for in emotionally unstable patients, such as those with a history of drug or alcohol dependence, because such patients may increase the dosage on their own initiative.
Slovenian: Posebna previdnost je potrebna pri čustveno neuravnovešenih bolnikih, bolnikih z zgodovino zlorabe drog ali odvisnostjo od alkohola, ker si ti bolniki lahko samovoljno povečajo odmerek zdravila.
English: Janssen-Cilag s.r.o., Karla Engliše 3201/6, 150 00 Praha 5 - Smíchov, Czech Republic
Slovenian: CS - Češka Janssen-Cilag s.r.o., Karla Engliše 3201/6, 150 00 Praha 5 - Smíchov, Czech Republic
English: If surgery is planned using a halogenated anaesthetic (a certain type of anaesthetic), you or your child should not take methylphenidate on the day of surgery, due to the risk of a sudden rise in blood pressure during surgery.
Slovenian: Če je načrtovan kirurški poseg z uporabo halogeniranega anestetika (določena oblika anestetika), vi ali vaš otrok zaradi tveganja nenadnega dviga krvnega tlaka med operativnim posegom na dan kirurškega posega ne smete vzeti metilfenidata.
English: Very common: insomnia, nervousness
Slovenian: Zelo pogosti: nespečnost, živčnost
English: The use of methylphenidate should always be used in this way according to the licensed indication and according to prescribing / diagnostic guidelines.
Slovenian: Metilfenidat je treba vedno uporabiti skladno z odobrenimi indikacijami in v skladu s smernicami za predpisovanje/diagnosticiranje.
English: Study CRIT124D2201 “An open label, behavioural treatment controlled evaluation of the effects of extended release methylphenidate (Ritalin LA) on the frequency of cytogenetic abnormalities in children 6-12 years old with attention deficit hyperactivity disorder”.
Slovenian: Študija CRIT124D2201 „Odprto, z behaviorističnim zdravljenjem nadzorovano vrednotenje učinkov metilfenidata s podaljšanim sproščanjem (Ritalin LA) na pogostnost citogenskih nenormalnosti pri otrocih, starih od 6 do 12 let, z motnjo pomanjkanja pozornosti in hiperaktivnostjo“.
English: Patients who are not growing or gaining height or weight as expected may need to have their treatment interrupted.
Slovenian: Pri bolnikih, ki ne rastejo in ne pridobivajo telesne višine ali mase v skladu s pričakovanji, je lahko potrebna prekinitev zdravljenja.
English: Hexal B.V.; Pastoorslaan 28; 2182 BX HILLEGOM/NL
Slovenian: ; Pastoorslaan 28; 2182 BX HILLEGOM/NL
English: Cardiovascular status should be carefully monitored.
Slovenian: Stanje srčnožilnega sistema pri bolniku je treba skrbno spremljati.
English: If you or your child is taking other medicines, methylphenidate may affect how well other medicines work or may cause side effects.
Slovenian: Če vi ali vaš otrok jemljete druga zdravila, lahko metilfenidat vpliva na uspešnost delovanja drugih zdravil ali povzroči neželene učinke.
English: In addition the harmonisation of the submission of the PSURs and the Risk Management Plans (RMP) by the MAHs will insure that the safety information is assessed simultaneously by the Members States via the PhVWP and the continuity of the harmonisation will be ensured.
Slovenian: Poleg tega bo usklajevanje oddaje rednih poročil o varnosti tveganja in načrtov obvladovanja tveganja s strani imetnikov dovoljenj za promet z zdravilom zagotovilo sočasno vrednotenje podatkov o varnosti v državah članicah preko Delovne skupine za farmakovigilanco, zagotovljena pa bo tudi kontinuiteta usklajevanja.
English: Administration of the tablets should not stop abruptly.
Slovenian: Uporabe tablet ne smete prekiniti nenadoma.
English: Effects on growth and maturation
Slovenian: Učinki na rast in dozorevanje
English: Learning may or may not be impaired.
Slovenian: Sposobnost učenja je lahko zmanjšana ali ne.
English: The CHMP concluded that the current initiatives to further evaluate any risk of carcinogenicity with methylphenidate are endorsed.
Slovenian: CHMP meni, da so trenutne pobude za dodatno vrednotenje vseh tveganj kancerogenosti zaradi metilfenidata dobrodošle.
English: The MAHs have committed to distribute education material for guidance of the prescribers.
Slovenian: Imetniki dovoljenj za promet z zdravilom so se zavezali k razdeljevanju izobraževalnega gradiva s priporočili za osebe, ki predpisujejo zdravila.
English: If you or your child is not growing or gaining weight as expected, then you or your child's treatment with methylphenidate may be stopped for a short time
Slovenian: Če vi ali vaš otrok ne rastete ali ne pridobivate na telesni masi po pričakovanjih, se lahko zdravljenje vas ali vašega otroka z metilfenidatom za krajši čas prekine.
English: Pharmachemie B.V.; Swensweg 5; 2003 RN HAARLEM/NL
Slovenian: ; Swensweg 5; 2003 RN HAARLEM/NL
English: Misuse and Cardiovascular Events
Slovenian: Napačna uporaba in srčnožilni dogodki
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from methylphenidate therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba, ali naj mati preneha dojiti ali naj raje prekine zdravljenje z metilfenidatom , ob upoštevanju koristi dojenja za otroka in koristi zdravljenja za mater.
English: DE - Germany 1 A Pharma GmbH Keltenring 1 + 3
Slovenian: DE - Nemčija 1 A Pharma GmbH Keltenring 1 + 3
English: Pregnancy and breast-feeding Tell your doctor or pharmacist before using methylphenidate if you or your child is: - sexually active.
Slovenian: Nosečnost in dojenje Pred uporabo metilfenidata obvestite svojega zdravnika ali farmacevta, če ste vi ali vaš otrok: - spolno aktivni.
English: There have been rare reports of obstructive symptoms in patients with known strictures in association with the ingestion of drugs in nondeformable prolonged-release formulations.
Slovenian: Obstajajo redka poročila o simptomih obstrukcije pri bolnikih z znanimi strikturami v povezavi z zaužitjem zdravil v oblikah s podaljšanim sproščanjem, ki se ne spremenijo.
English: Frank psychotic episodes can occur, especially in response to parenteral abuse.
Slovenian: Lahko pride celo do očitnih psihotičnih epizod, še posebej pri parenteralni zlorabi zdravila.
English: Very rare: cerebral arteritis and/or occlusion, peripheral coldness, Raynaud's phenomenon
Slovenian: Zelo redki: možganski arteritis in/ali zapora, periferna hladnost, Raynaudov fenomen
English: BG - Bulgaria Johnson & Johnson D.O.O.
Slovenian: BG - Bolgarija Johnson & Johnson D.O.O.
English: Methylphenidate did not affect reproductive performance or fertility at low multiples of the clinical dose.
Slovenian: Metilfenidat ni vplival na uspešnost reprodukcije ali na plodnost pri majhnih večkratnih kliničnih odmerkih.
English: Conversely, the d- and l- enantiomers of methylphenidate do not relevantly inhibit cytochrome P450 1A2, 2C8, 2C9, 2C19, 2D6, 2E1 or 3A.
Slovenian: Ni pričakovati, da bi imeli induktorji ali zaviralci citokroma P450 kakršenkoli pomemben vpliv na farmakokinetiko metilfenidata, velja tudi obratno, namreč da d- in l- enantiomer metilfenidata ne zavirata citokroma P450 1A2, 2C8, 2C9, 2C19, 2D6, 2E1 ali 3A v pomembni meri.
English: • palpitations, unexplained fainting chest pain, shortness of breath ( these can sometimes be signs of cardiac disease)
Slovenian: • palpitacije, nerazložljiva omedlevica, bolečina v prsih, zasoplost (to so včasih lahko znaki srčnega obolenja);
English: When starting or stopping treatment with methylphenidate, it may be necessary to adjust the dosage of these drugs already being taken and establish drug plasma concentrations (or for coumarin, coagulation times).
Slovenian: Ob uvedbi ali ukinitvi zdravljenja z metilfenidatom bo morda potrebna prilagoditev odmerka zdravil, ki jih bolnik že jemlje, in določitev plazemskih koncentracij zdravila (oziroma pri kumarinu določitev časa koagulacije).
English: Treatment with methylphenidate is not contraindicated in patients with hemiplegic cerebral palsy
Slovenian: Zdravljenje z metilfenidatom ni kontraindicirano pri bolnikih s hemiplegično cerebralno paralizo.
English: Before you start treatment, at every change of dose and then at least every 6 months or every visit your doctor will conduct various tests to make sure that methylphenidate is still acceptabley safe and beneficial.
Slovenian: Zdravnik bo pred pričetkom zdravljenja, ob vsaki spremembi odmerka in nato vsaj vsakih 6 mesecev ali ob vsakem obisku izvedel različne preskuse, da zagotovi, da je metilfenidat še vedno sprejemljivo varen in koristen.
English: The use of methylphenidate is contraindicated in certain pre-existing cardiovascular disorders unless specialist paediatric cardiac advice has been obtained (see Section 4.3 ‘Contraindications').
Slovenian: Uporaba metilfenidata je pri določenih srčnožilnih motnjah kontraindicirana, razen če je bilo pridobljeno mnenje pediatra kardiologa (glejte poglavje 4.3).
English: 2.1.c Pre-clinical data
Slovenian: 2.1.c Predklinični podatki
English: On 22 June 2007, the European Commission requested a referral to the CHMP under Article 31 of Directive 2001/83/EC, as amended, for all methylphenidate containing products.
Slovenian: Evropska komisija je 22. junija 2007 za vsa zdravila, ki vsebujejo metilfenidat, zahtevala napotitev na Odbor za zdravila za uporabo v humani medicini skladno s členom 31 Direktive 2001/83/ES, kakor je bila spremenjena.
English: ALFRED E TIEFENBACHER GMBH & CO; VAN-DER-SMISSEN-STRASSE 1; HAMBURG D-22767; GERMANY
Slovenian: ALFRED E TIEFENBACHER GMBH & CO; VAN-DER-SMISSENSTRASSE 1; HAMBURG D-22767; GERMANY
English: Overall, it can be concluded that the exact causal mechanism for the effects of methylphenidate on growth remains uncertain.
Slovenian: Splošen zaključek je bil, da natančni vzročni mehanizem učinkov metilfenidata na rast ostaja neznan.
English: - The CHMP concluded that the Product Information of all methylphenidate-containing products should include the same safety information and therefore recommended the harmonisation of relevant sections of the Summaries of Product Characteristics and Package Leaflets.
Slovenian: - CHMP je zaključil, da morajo podatki o vseh zdravilih, ki vsebujejo metilfenidat, vsebovati enake podatke o varnosti, zato priporoča uskladitev zadevnih poglavij povzetkov glavnih značilnosti zdravila in navodil za uporabo.
English: • about any mental health/psychiatric/behavioural problems you or your child or other family members have or have had in the past.
Slovenian: • o kakršnihkoli sedanjih ali preteklih težavah duševnega zdravja/psihiatričnih/vedenjskih težavah, ki zadevajo vas, vašega otroka ali druge člane družine.
English: 2.3 Psychiatric risk
Slovenian: 2.3 Tveganje psihiatričnih motenj
English: Some pre-clinical evidence was submitted suggesting that there is a differential effect of acute vs. chronic treatment with methylphenidate on expression of genes involved in neuronal plasticity, a differential effect of methylphenidate exposure in juveniles vs adults on expression of central neurotransmitter receptors and an effect of treatment in adolescence on survival of new brain cells.
Slovenian: Predloženih je bilo nekaj dokazov iz predkliničnih študij, ki kažejo različen učinek akutnega oz. kroničnega zdravljenja z metilfenidatom na izražanje genov, ki sodelujejo pri nevronski plastičnosti, različen učinek izpostavitve metilfenidatu na izražanje centralnih nevrotransmiterskih receptorjev pri mladostnikih oz. odraslih in učinek zdravljenja v mladostništvu na preživetje novih možganskih celic.
English: The maximum daily dosage of methylphenidate is {to be completed nationally}.
Slovenian: Največji dnevni odmerek metilfenidata je [izpolni država članica]
English: Novartis Healthcare Lyngbyvej 172
Slovenian: DK - Danska Novartis Healthcare Lyngbyvej 172
English: If you are in any doubt about whether any medicines you or your child is taking are included in the list above, ask your doctor or pharmacist before taking methylphenidate.
Slovenian: Če dvomite, ali je katero od zdravil, ki ga jemljete vi ali vaš otrok, vključeno na zgornji seznam, se pred jemanjem metilfenidata posvetujte s svojim zdravnikom ali farmacevtom.
English: Your doctor may decide you or your child need other medical tests before you or your child take this medicine.
Slovenian: Zdravnik lahko odloči, da je treba, preden vzamete to zdravilo, pri vas ali vašem otroku opraviti še druge medicinske preskuse.
English: • to measure you or your child's height and weight, heart rate and blood pressure and will record these on a chart
Slovenian: • da bo vam in vašemu otroku izmeril telesno višino in maso, srčni utrip in krvni tlak ter vrednosti zabeležil na diagram;
English: Methylphenidate is associated with the worsening of pre-existing anxiety, agitation or tension.
Slovenian: Metilfenidat so povezovali s poslabšanjem obstoječe tesnobe, razburjenosti ali napetosti.
English: Methylphenidate is not metabolised by cytochrome P450 to a clinically relevant extent.
Slovenian: Metilfenidat se ne presnavlja s citokromom P450 v klinično pomembni meri.