FrancophonIA/ELRC3.0 huggingface dataset:
English: Ammonaps may still be supplied where no alternatives are available
Croatian: Moguć je nastavak opskrbe lijekom Ammonaps ako nisu dostupni alternativni lijekovi
English: Pharmaceutics International Inc, US: supply of noncritical medicines to EU stopped due to manufacturing failings
Croatian: Pharmaceutics International Inc, SAD: obustava opskrbe
English: Date of latest renewal: 19 November 2014
Croatian: Datum posljednje obnove odobrenja: 19. studenog 2014.
English: • Third trimester of pregnancy (see section 4.6).
Croatian: • u trećem tromjesječju trudnoće (vidjeti dio 4.6.).
English: Other medicines and DuoPlavin
Croatian: Drugi lijekovi i DuoPlavin
English: From the beginning of the sixth month of pregnancy, all prostaglandin synthesis inhibitors may expose:
Croatian: Od početka šestog mjeseca trudnoće, svi inhibitori sinteze prostaglandina mogu uzrokovati:
English: Some other medicines may influence the use of DuoPlavin or vice versa.
Croatian: Neki lijekovi mogu utjecati na djelovanje DuoPlavina ili obratno.
English: What DuoPlavin is and what it is used for
Croatian: Što je DuoPlavin i za što se koristi
English: At low concentrations (<100 micrograms/ml), approximately 90% of salicylic acid is bound to albumin.
Croatian: Pri niskim koncentracijama (<100 µg/ml), otprilike 90% salicilatne kiseline vezano je za albumin.
English: Their frequency is defined using the following conventions: common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Njihova je učestalost definirana na sljedeći način: česte (≥1/100, <1/10); manje česte (≥1/1000, <1/100); rijetke (≥1/10 000, <1/1000); vrlo rijetke (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: (See section 4.8.)
Croatian: (Vidjeti dio 4.8)
English: Therefore, this combination should be used with caution in patients taking low dose ASA for cardioprotection .
Croatian: Stoga se ova kombinacija treba primjenjivati s oprezom u bolesnika koji uzimaju nisku dozu ASK za kardioprotekciju.
English: Fever, edema*
Croatian: Vrućica, edem*
English: The safety and efficacy of DuoPlavin in children and adolescents under 18 years old have not been established.
Croatian: Sigurnost i djelotvornost lijeka DuoPlavin u djece i adolescenata do 18 godina starosti još nije ustanovljena.
English: If patients must temporarily stop antiplatelet therapy, DuoPlavin should be discontinued 7 days prior to surgery.
Croatian: Ako bolesnik mora privremeno prekinuti antitrombocitnu terapiju, DuoPlavin treba prestati uzimati 7 dana prije kirurškog zahvata.
English: While you are taking DuoPlavin:
Croatian: Dok uzimate DuoPlavin:
English: Store below 25°C.
Croatian: Čuvati na temperaturi ispod 25ºC.
English: What DuoPlavin is and what it is used for What you need to know before you take DuoPlavin How to take DuoPlavin
Croatian: Što je DuoPlavin i za što se koristi Što morate znati prije nego počnete uzmati DuoPlavin Kako uzimati DuoPlavin
English: DuoPlavin should not be used during the first two trimesters of pregnancy unless the clinical condition of the woman requires treatment with clopidogrel/ASA.
Croatian: DuoPlavin se ne smije koristiti tijekom prva dva tromjesječja trudnoće, osim ako kliničko stanje bolesnice zahtijeva liječenje klopidogrelom/ASK.
English: DuoPlavin is not intended for use in children or adolescents less than 18 years of age.
Croatian: DuoPlavin nije namijenjen liječenju djece ili adolescenata mlađih od 18 godina.
English: The recommended dose is one tablet of DuoPlavin per day to be taken orally with a glass of water, with or without food.
Croatian: Uobičajena doza je jedna tableta DuoPlavina dnevno koja se uzima kroz usta, s čašom vode, s hranom ili bez nje.
English: The other ingredients are:
Croatian: Ostale nuspojave uključuju:
English: Following toxic doses (10 20 g), the plasma half-life may be increased to over 20 hours.
Croatian: Nakon toksičnih doza (10-20 g) poluvijek u plazmi može biti produljen na preko 20 sati.
English: If any of the situations mentioned below apply to you, you should tell your doctor before taking DuoPlavin:
Croatian: Ako se na Vas odnosi bilo koje od dolje navedenih stanja, morate obavijestiti liječnika prije nego što uzmete DuoPlavin:
English: Store below 25C.
Croatian: Čuvati na temperaturi ispod 25C.
English: Patients should inform physicians and dentists that they are taking DuoPlavin before any surgery is scheduled and before any new medicinal product is taken.
Croatian: Bolesnici trebaju obavijestiti liječnika ili stomatologa o uzimanju DuoPlavina prije planiranja bilo kakvog kirurškog zahvata i prije početka uzimanja bilo kojeg novog lijeka.
English: This leaflet was last revised in <Month YYYY>.
Croatian: Ova uputa je zadnji puta revidrana u <mjesec GGGG>.
English: What you need to know before you take DuoPlavin
Croatian: Što morate znati prije nego počnete uzimati DuoPlavin
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 15 March 2010
Croatian: Datum prvog odobrenja: 15. ožujak 2010.
English: By preventing this clumping in some types of blood vessels (called arteries), antiplatelet medicinal products reduce the chances of blood clots forming (a process called atherothrombosis).
Croatian: Sprječavanjem tog nakupljanja u nekim vrstama krvih žila (arterijama), antitrombocitni lijekovi smanjuju mogućnost stvaranja krvnih ugrušaka (proces koji se zove aterotromboza).
English: TOPIC (Timing Of Platelet Inhibition after acute Coronary syndrome)
Croatian: Timing of Platelet Inhibition after Acute Coronary Syndrome)
English: In patients with ST segment elevation acute myocardial infarction: Therapy should be started as early as possible after symptoms start and continued for at least four weeks.
Croatian: U bolesnika s akutnim infarktom miokarda s elevacijom ST-segmenta: liječenje treba započeti što je ranije moguće nakon pojave simptoma te nastaviti tijekom najmanje 4 tjedna.
English: This was associated with a reduction of the mean inhibition of platelet aggregation by 15% and 11%, respectively.
Croatian: To je bilo povezano sa smanjenjem prosječne vrijednosti inhibicije agregacije trombocita od 15% i 11%.
English: A pharmacodynamic interaction between DuoPlavin and heparin is possible, leading to increased risk of bleeding.
Croatian: Farmakodinamička interakcija između DuoPlavina i heparina je moguća i može povećati rizik od krvarenja.
English: Do not take DuoPlavin during third trimester of pregnancy.
Croatian: Nemojte uzimati DuoPlavin u trećem tromjesečju trudnoće.
English: Single-dose studies have shown that the oral toxicity of ASA is low.
Croatian: Ispitivanja sa jednokratnom dozom pokazala su da je oralna toksičnost ASK niska.
English: If acetylsalicylic acid is used by a woman attempting to conceive, or until the 24th amenorrhea week (5th month of pregnancy), the dose should be kept as low and duration of treatment as short as possible.
Croatian: Ako acetilsalicilatnu kiselinu uzimaju žene koje pokušavaju začeti ili žene do 24-og tjedna amenoreje (5-og mjeseca trudnoće), doza treba biti što niža, a trajanje liječenja što kraće.
English: Driving and using machines DuoPlavin should not affect your ability to drive or to use machines.
Croatian: Upravljanje vozilima i strojevima DuoPlavin ne bi trebao utjecati na Vašu sposobnost upravljanja vozilima ili strojevima.
English: Do not use this medicine after the expiry date which is stated on the carton and on the blister, after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake "EXP“
English: For the treatment of this condition your doctor may have placed a stent in the blocked or narrowed artery to restore effective blood flow.
Croatian: Za liječenje tog stanja liječnik vam je možda ugradio stent (cjevčicu koja krvnu žilu drži protočnom) u začepljenu ili suženu arteriju da bi ponovno uspostavio normalan protok krvi.
English: What DuoPlavin looks like and contents of the pack
Croatian: Kako DuoPlavin izgleda i sadržaj pakiranja
English: If you become pregnant while taking DuoPlavin, consult your doctor immediately as it is recommended not to take DuoPlavin while you are pregnant.
Croatian: Ako zatrudnite za vrijeme uzimanja DuoPlavina, odmah se posavjetujte s liječnikom, jer nije preporučeno uzimati DuoPlavin za vrijeme trudnoće.
English: For the 14, 28 and 84 tablets pack sizes you can check the day on which you last took a tablet of DuoPlavin by referring to the calendar printed on the blister.
Croatian: Za pakiranja od 14, 28 i 84 tablete možete pomoću kalendara otisnutog na blisteru provjeriti dan kada ste zadnji put uzeli tabletu DuoPlavina.
English: Due to the presence of both components of the medicinal product, DuoPlavin is contraindicated in case of:
Croatian: Zbog prisutnosti dvije djelatne tvari u lijeku, DuoPlavin je kontraindiciran u slučaju:
English: * Information reported in published information for ASA with frequency “not known”.
Croatian: * Podaci se odnose na objavljene podatke za ASK s učestalosti „nepoznato“.
English: DuoPlavin contains clopidogrel and acetylsalicylic acid (ASA) and belongs to a group of medicines called antiplatelet medicinal products.
Croatian: DuoPlavin sadrži klopidogrel i acetilsalicilatnu kiselinu (ASK) i pripada skupini lijekova koji se nazivaju antitrombocitni lijekovi.
English: 5 How to store DuoPlavin Contents of the pack and other information
Croatian: Kako čuvati DuoPlavin Sadržaj pakiranja i druge informacije
English: Clinical studies indicate that doses up to 100 mg/day for restricted obstetrical use, which require specialised monitoring, appear safe.
Croatian: Klinička ispitivanja upućuju na to da se primjena doze do 100 mg dnevno, u ograničenoj opstetricijskoj uporabi, koja zahtijeva posebno motrenje, čini sigurna.
English: The benefit of the combination of clopidogrel with ASA beyond four weeks has not been studied in this setting (see section 5.1).
Croatian: Korist kombinacije klopidogrela s ASK u trajanju dužem od 4 tjedna nije ispitivana u ovim okolnostima (vidjeti dio 5.1.).
English: There is no evidence that other medicinal products that reduce stomach acid such as H2 blockers or antacids interfere with antiplatelet activity of clopidogrel.
Croatian: Nema dokaza da drugi lijekovi koji smanjuju lučenje želučane kiseline, poput H2 blokatora ili antacida, utječu na antitrombocitni učinak klopidogrela.
English: Doses of 100-500 mg/day:
Croatian: Doze od 100-500 mg dnevno:
English: • the mother and the neonate, at the end of pregnancy, to: - possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses; - inhibition of uterine contractions resulting in delayed or prolonged labour.
Croatian: • majke i novorođenčad, pri kraju trudnoće: - moguće produljenje vremena krvarenja, antitrombocitni učinak koji se može pojaviti već pri vrlo niskim dozama; - inhibiciju kontrakcija maternice što za ishod može imati odgođeni ili produljeni porod.
English: Clinical trial data support use up to 12 months, and the maximum benefit was seen at 3 months (see section 5.1).
Croatian: Rezultati kliničkih ispitivanja podupiru trajanje liječenja do najviše 12 mjeseci, a najveći učinak zabilježen je nakon 3 mjeseca liječenja (vidjeti dio 5.1.).
English: Salicylic acid is widely distributed to all tissues and fluids in the body, including the central nervous system, breast milk, and foetal tissues.
Croatian: Salicilatna kiselina dobro je raspodjeljena po svim tkivima i tekućinama u tijelu uključujući središnji živčani sustav, majčino mlijeko i fetalno tkivo.
English: No clinical data on exposure to DuoPlavin during pregnancy are available.
Croatian: Nisu dostupni klinički podaci o primjeni DuoPlavina tijekom trudnoće.
English: ** Information related to clopidogrel with frequency “not known”.
Croatian: ** Podaci se odnose na klopidogrel s učestalosti „nepoznato“.
English: As no clinical data on exposure to clopidogrel during pregnancy are available, it is preferable not to use clopidogrel during pregnancy as a precautionary measure.
Croatian: S obzirom na to da nema dostupnih podataka o izloženosti klopidogrelu tijekom trudnoće, preporučljivo je, kao mjera opreza, ne koristiti klopidogrel za vrijeme trudnoće.
English: Repeated doses of clopidogrel 75 mg per day produced substantial inhibition of ADP-induced platelet aggregation from the first day; this increased progressively and reached steady state between Day 3 and Day 7.
Croatian: Ponovljene doze klopidogrela od 75 mg dnevno uzrokuju snažnu inhibiciju ADP-om posredovane agregacije trombocita od prvoga dana; to se progresivno pojačava i doseže stanje dinamičke ravnoteže između dana 3 i dana 7.
English: DuoPlavin is not recommended in this population.
Croatian: DuoPlavin se ne preporučuje ovoj skupini bolesnika.
English: If you are pregnant or suspect that you are pregnant, you should tell your doctor or your pharmacist before taking DuoPlavin.
Croatian: Ako ste trudni ili sumnjate na trudnoću, obavijestite svog liječnika ili ljekarnika prije nego što uzmete DuoPlavin.
English: New cardiovascular events (primary endpoint) were prevented, with relative risk reductions of 22% (CI: 8.6, 33.4), 32% (CI: 12.8, 46.4), 4% (CI: -26.9, 26.7), 6% (CI: -33.5, 34.3) and 14% (CI: -31.6, 44.2), during the 0-1, 1-3, 3-6, 6-9 and 9-12 month study intervals, respectively.
Croatian: Novi kardiovaskularni događaji (primarni ishod) su spriječeni, sa smanjenjem relativnoga rizika od 22% (CI: 8,6; 33,4), 32% (CI: 12,8; 46,4), 4% (CI:26,9; 26,7), 6% (CI: -33,5; 34,3) i 14% (CI: -31,6; 44,2) tijekom razdoblja u studiji od 0 do 1 mjesec, 1 do 3 mjeseca, 3 do 6 mjeseci, 6 do 9 mjeseci, odnosno 9 do 12 mjeseci.
English: It also contains: lactose and hydrogenated castor oil.
Croatian: Također sadrži: laktozu i hidrogenirano ricinusovo ulje.
English: DuoPlavin prolongs bleeding time and should be used with caution in patients who have lesions with a propensity to bleed (particularly gastrointestinal and intraocular).
Croatian: DuoPlavin produljuje vrijeme krvarenja, te ga s oprezom treba davati bolesnicima koji imaju lezije sklone krvarenju (posebice gastrointestinalne i intraokularne).
English: DuoPlavin is a fixed-dose combination medicinal product for continuation of therapy in:
Croatian: DuoPlavin je lijek sa fiksnom kombinacijom djelatnih tvari koji je namijenjen za nastavak terapije:
English: Apart from the specific medicinal product interaction information described above, interaction studies with DuoPlavin and some medicinal products commonly administered in patients with atherothrombotic disease have not been performed.
Croatian: Osim gore opisanih specifičnih interakcija, nisu provedena ispitivanja interakcija DuoPlavina s drugim lijekovima koji se obično propisuju bolesnicima s aterotrombotskim bolestima.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER / 14, 28 and 84 tablets
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP BLISTER / 14, 28 i 84 tablete
English: Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Croatian: Omeprazol primjenjen u dozi od 80 mg dnevno, istodobno s klopidogrelom ili s razmakom od 12 sati između primjene dvaju lijekova, smanjio je izloženost aktivnom metabolitu za 45% (udarna doza) i 40% (doza održavanja).
English: Due to the presence of ASA, DuoPlavin is contraindicated during the third trimester of pregnancy.
Croatian: Zbog ASK u svome sastavu, Duoplavin je kontraindiciran tijekom trećeg tromjesečja trudnoće.
English: If you stop taking DuoPlavin
Croatian: Ako prestanete uzimati Duoplavin
English: For minor cuts and injuries e.g., cutting yourself, shaving, this is usually of no concern.
Croatian: Za male posjekotine ili ozljede, primjerice, porezotine nastale tijekom brijanja, obično se ne trebate zabrinjavati.
English: Pharmacotherapeutic group: Antithrombotic agents, platelet aggregation inhibitors excl. Heparin, ATC Code: B01AC30.
Croatian: Farmakoterapijska skupina: antitrombotici, inhibitori agregacije trombocita izuzev heparina, ATK oznaka: B01AC30.
English: A patient with poor metaboliser status will possess two loss-offunction alleles as defined above.
Croatian: Bolesnici sa statusom sporih metabolizatora imaju 2 nefunkcionalna alela kako je definirano gore.
English: DuoPlavin is indicated for the secondary prevention of atherothrombotic events in adult patients already taking both clopidogrel and acetylsalicylic acid (ASA).
Croatian: DuoPlavin je indiciran za sekundarnu prevenciju aterotrombotičnih događaja u odraslih bolesnika koji već uzimaju klopidogrel i acetilsalicilatnu kiselinu (ASK).
English: In one study, when a single dose of ibuprofen 400 mg was taken within 8 hours before or within 30 minutes after immediate release aspirin dosing (81 mg), a decreased effect of ASA on the formation of thromboxane or platelet aggregation occurred.
Croatian: U jednom ispitivanju, u kojem je primjenjena jednokratna doza ibuprofena od 400 mg unutar 8 sati prije ili unutar 30 min nakon uzimanja ASK s trenutnim otpuštanjem u dozi od 81 mg, primjećen je smanjeni učinak ASK na stvaranje tromboksana ili agregaciju trombocita.
English: However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 2 ‘Warnings and precautions').
Croatian: Ako ste ipak zabrinuti zbog krvarenja, odmah obavijestite svog liječnika (vidjeti dio 2. "Upozorenja i mjere opreza").
English: If you forget to take a dose of DuoPlavin, but remember within 12 hours of your usual time, take your tablet straightaway and then take your next tablet at the usual time.
Croatian: Ako zaboravite uzeti dozu DuoPlavina, ali se toga sjetite u roku od 12 sati, odmah uzmite tabletu, a sljedeću tabletu uzmite u uobičajeno vrijeme.
English: In animals, administration of a prostaglandin synthesis inhibitor has been shown to result in reproductive toxicity (see section 5.3).
Croatian: Primjena inhibitora sinteze prostaglandina u životinja, rezultirala je reproduktivnom toksičnošću (vidjeti dio 5.3.).
English: You have been prescribed DuoPlavin in place of the two separate medicines, clopidogrel and ASA, to help prevent blood clots because you have experienced a severe type of chest pain known as ‘unstable angina' or heart attack (myocardial infarction).
Croatian: DuoPlavin Vam je propisan u zamjenu za dva odvojena lijeka, klopidogrel i ASK, u svrhu sprječavanja stvaranja krvnih ugrušaka jer ste imali teški oblik boli u prsištu, koji je poznat pod nazivom "nestabilna angina" ili ste imali srčani udar (infarkt miokarda).
English: Due to the risk of bleeding and haematological adverse reactions, blood cell count determination and/or other appropriate testing should be promptly considered whenever clinical symptoms suggestive of bleeding arise during the course of treatment (see section 4.8).
Croatian: Zbog rizika od krvarenja i hematoloških nuspojava, potrebno je odmah provjeriti krvnu sliku i/ili napraviti druge odgovarajuće pretrage kad god se tijekom liječenja pojave klinički simptomi koji ukazuju na krvarenje (vidjeti dio 4.8.).
English: DuoPlavin is taken by adults to prevent blood clots forming in hardened arteries which can lead to atherothrombotic events (such as stroke, heart attack, or death).
Croatian: DuoPlavin uzimaju odrasli za sprječavanje stvaranja krvnih ugrušaka (tromba) u zadebljanim arterijama, što može dovesti do aterotrombotičkih događaja (kao što su moždani udar, srčani udar ili smrt).
English: • Severe renal impairment (creatinine clearance <30 ml/min).
Croatian: • kod teškog oštećenja funkcije bubrega (klirens kreatinina<30 ml/min),
English: In a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and naproxen increased occult gastrointestinal blood loss.
Croatian: U jednom kliničkom ispitivanju sa zdravim dobrovoljcima, istodobna primjena klopidrogela i naproksena povećala je gastrointestinalno okultno krvarenje.
English: The safety and efficacy of clopidogrel plus ASA have been evaluated in three double-blind studies involving over 61,900 patients: the CURE, CLARITY and COMMIT studies, comparing clopidogrel plus ASA to ASA alone, both treatments given in combination with other standard therapy.
Croatian: Sigurnost primjene i djelotvornost klopidogrela plus ASK procijenjeni su u tri dvostrukoslijepe studije koje su uključivale preko 61 900 bolesnika: CURE, CLARITY i COMMIT studije, u kojima se uspoređivalo djelovanje klopidogrela plus ASK prema samoj ASK, s tim da su obje terapije davane u kombinaciji s drugim standardnim terapijama.
English: Following an oral dose of 14C-labelled clopidogrel in man, approximately 50% was excreted in the urine and approximately 46% in the faeces in the 120-hour interval after dosing.
Croatian: Nakon primjene oralne doze 14C radioaktivno označenog klopidogrela u ljudi, otprilike 50% doze se izlučuje u urinu te otprilike 46% u fecesu u razdoblju od 120 sati nakon doziranja.
English: This medicinal product also contains hydrogenated castor oil which may cause stomach upset and diarrhoea.
Croatian: Ovaj lijek također sadrži hidrogenirano ricinusovo ulje koje može uzrokovati probavne smetnje i proljev.
English: Follow-up at one year was performed for 316 patients (98.1%) in the de-escalated DAPT group and 318 patients (98.5%) in the unchanged DAPT group.
Croatian: Nakon godine dana provedeno je praćenje 316 bolesnika (98,1%) u skupini sa de-eskaliranim DAPT-om i 318 bolesnika (98,5%) u skupini sa nepromijenjenim DAPTom.
English: In patients with recent transient ischaemic attack or stroke who are at high risk of recurrent ischaemic events, the combination of ASA and clopidogrel has been shown to increase major bleeding.
Croatian: U bolesnika s TIA-om ili moždanim udarom, koji su izloženi visokom riziku recidiva ishemijskih događaja, utvrđeno je da kombinacija ASK i klopidogrela pojačava velika krvarenja.
English: • the foetus to: - cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension); - renal dysfunction, which may progress to renal failure with oligo-hydroamniosis;
Croatian: • fetus: - kardiopulmonalnu toksičnost (s preranim zatvaranjem duktusa arteriosusa i plućnom hipertenzijom); - bubrežnu disfunkciju, koja se može razviti u bubrežno zatajenje sa oligohidroamnionom;
English: Depending on your condition, your doctor will determine the length of time for which you need to take DuoPlavin.
Croatian: Ovisno o Vašem stanju, liječnik će Vam odrediti duljinu terapije lijekom DuoPlavin.
English: Physicians should remain alert for signs of GI ulceration and bleeding, even in the absence of previous GI symptoms.
Croatian: Liječnici trebaju obratiti pozornost na znakove gastrointestinalnih ulceracija i krvarenja, čak i u izostanku navedenih gastointestinalnih simptoma.
English: Patients should be told about the signs and symptoms of GI undesirable effects and what steps to take if they occur.
Croatian: Bolesnicima treba objasniti znakove i simptome mogućih gastrointestinalnih nuspojava i što učiniti ako se pojave.
English: The guided de-escalation did not result in an increased combined risk of ischemic events (2.5% in the deescalation group vs 3.2% in the control group; p non-inferiority=0.0115), nor in the key secondary endpoint of BARC bleeding ≥2 ((5%) in the de-escalation group versus 6% in the control group
Croatian: Vođena de-eskalacija nije rezultirala povećanjem u kombiniranom riziku od ishemijskih događaja (2,5 % u skupini sa vođenom de-eskalacijom u odnosu na 3,2% u kontrolnoj skupini; p neinferiornosti=0,0115) niti u ključnoj sekundarnoj mjeri ishoda BARC stupnja krvarenja ≥ 2 ((5%) u skupini s vođenom de-eskalacijom nasuprot 6% u kontrolnoj skupini (p=0,23)).
English: Therefore DuoPlavin should be used with caution in these patients.
Croatian: Stoga, u tih bolesnika, DuoPlavin treba primjenjivati s oprezom.