FrancophonIA/ELRC3.0 huggingface dataset:
English: In a separate clinical pharmacokinetic interaction study of healthy subjects, co-administration of ketoconazole, a strong inhibitor of CYP3A4, had no clinically meaningful effect on the pharmacokinetics of abiraterone.
Croatian: U odvojenom kliničkom ispitivanju farmakokinetičkih interakcija u zdravih ispitanika, istodobna primjena ketokonazola, snažnog CYP3A4 inhibitora nije imala klinički značajan učinak na farmakokinetiku abiraterona.
English: In all studies spironolactone use was not allowed as spironolactone binds to the androgen receptor and may increase PSA levels.
Croatian: U svim ispitivanjima primjena spironolaktona nije bila dopuštena, budući da se spironolakton veže na androgene receptore i može povisiti razine PSA.
English: Six hundred and seven (607) subjects had radiographic progression or died: 271 (50%) in the abiraterone acetate group and 336 (62%) in the placebo group.
Croatian: Šeststosedam (607) ispitanika imalo je radiografsku progresiju ili je umrlo: 271 (50%) u skupini koja je primala abirateronacetat i 336 (62%) u skupini koja je primala placebo.
English: In these fertility and developmental toxicity studies performed in the rat, all effects were related to the pharmacological activity of abiraterone.
Croatian: U ovim ispitivanjima plodnosti i ispitivanjima razvojne toksičnosti koja su provedene na štakorima, svi učinci su bili povezani s farmakološkom aktivnosti abiraterona.
English: Patients were not required to show disease progression on docetaxel, as toxicity from this chemotherapy may have led to discontinuation.
Croatian: Kod bolesnika se nije moralo doći do progresije bolesti dok su na docetakselu, jer je zbog toksičnosti ove kemoterapije moglo doći do prestanka primjene lijeka.
English: Treatment with ZYTIGA should not be reinitiated until symptoms of the toxicity have resolved to Grade 1 or baseline.
Croatian: Liječenje lijekom ZYTIGA ne treba ponovno uvoditi dok se simptomi toksičnosti ne smanje do stupnja 1, ili povuku na početne vrijednosti.
English: For patients who develop Grade ≥ 3 toxicities including hypertension, hypokalaemia, oedema and other non-mineralocorticoid toxicities, treatment should be withheld and appropriate medical management should be instituted.
Croatian: Za bolesnike koji razviju toksičnosti stupnja ≥ 3 uključujući hipertenziju, hipokalemiju, edem i druge nemineralokortikoidne toksičnosti, liječenje treba prekinuti te uvesti prikladnu medicinsku skrb.
English: During treatment, blood pressure, serum potassium, fluid retention (weight gain, peripheral oedema), and other signs and symptoms of congestive heart failure should be monitored every 2 weeks for 3 months, then monthly thereafter and abnormalities corrected.
Croatian: Tijekom liječenja treba kontrolirati krvni tlak, kalij u serumu, zadržavanje tekućine (povećanje težine, periferni edemi) i druge znakove i simptome kongestivnog zatajenja srca, svaka 2 tjedna tijekom tri mjeseca, a nakon toga jednom mjesečno i korigirati primijećena odstupanja.
English: Taking the tablets with food increases systemic exposure to abiraterone (see sections 4.5 and 5.2).
Croatian: Uzimanje tableta s hranom povećava sustavnu izloženost abirateronu (vidjeti dijelove 4.5 i 5.2).
English: Each carton contains one bottle.
Croatian: Svaka kutija sadrži jednu bocu.
English: Frequency categories are defined as follows: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000) and not known (frequency cannot be estimated from the available data).
Croatian: U tablici su nuspojave zabilježene u kliničkim ispitivanjima i nakon stavljanja lijeka u promet popisane prema kategorijama učestalosti, definiranima kao: vrlo često (≥ 1/10); često (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000) i nepoznato (učestalost se ne može procijeniti iz dostupnih podataka).
English: Prior use of ketoconazole
Croatian: Prethodna primjena ketokonazola
English: Do not take ZYTIGA - if you are allergic to abiraterone acetate or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati lijek ZYTIGA - ako ste alergični na abirateronacetat ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.). - ako ste žena, a posebice ako ste trudni.
English: Round white HDPE bottles fitted with a polypropylene child-resistant closure containing 120 tablets.
Croatian: Okrugle, bijele boce od polietilena visoke gustoće (HDPE) s polipropilenskim sigurnosnim zatvaračem za djecu, koje sadrže 120 tableta.
English: Patients were using an LHRH analogue or were previously treated with orchiectomy.
Croatian: Bolesnici su primali neki LHRH-analog ili su prethodno podvrgnuti orhidektomiji.
English: In addition to the observed improvement in overall survival, all secondary study endpoints favoured ZYTIGA and were statistically significant after adjusting for multiple testing as follows:
Croatian: Osim opaženog poboljšanja ukupnog preživljenja, sve sekundarne mjere ishoda išle su u korist lijeka ZYTIGA i bile su statistički značajne nakon prilagodbe za višestruke testove, kako slijedi:
English: In Study 3011, grade 3 or 4 hepatotoxicity was observed in 8.4% of patients treated with ZYTIGA.
Croatian: U ispitivanju 3011, hepatotoksičnosti stupnja 3 i 4 bile su zabilježene u 8,4% bolesnika liječenih lijekom ZYTIGA.
English: It is recommended that subsequent treatment with Ra-223 is not initiated for at least 5 days after the last administration of ZYTIGA in combination with prednisone/prednisolone.
Croatian: Sljedeće liječenje s Ra-223 nije preporučeno započinjati barem 5 dana nakon zadnje primjene lijeka ZYTIGA u kombinaciji s prednizonom/prednizolonom.
English: Censored
Croatian: Cenzurirano
English: CYP17 inhibition also results in increased mineralocorticoid production by the adrenals (see section 4.4).
Croatian: Inhibicija CYP17 dovodi i do povećanog stvaranja mineralokortikoida u nadbubrežnim žlijezdama (vidjeti dio 4.4).
English: Patients that were treated with prior pharmacotherapy, radiation therapy, or surgery for metastatic prostate cancer were excluded with the exception of up to 3 months of ADT or 1 course of palliative radiation or surgical therapy to treat symptoms resulting from metastatic disease.
Croatian: Bolesnici koji su bili prethodno liječeni farmakoterapijom, radioterapijom ili kirurškim zahvatom metastatskog raka prostate bili su isključeni s iznimkom od najviše 3 mjeseca ADT-a ili 1 ciklusa palijativne radijacije ili kirurškog zahvata za liječenje simptoma koji su rezultat metastatske bolesti.
English: Based on a cumulative review of the data in relation to latency of rhabdomyolysis/myopathy cases, almost half of these cases occurred between 1 to 6 months after initiation of therapy with abiraterone acetate (AA).
Croatian: Temeljem kumulativnog pregleda podataka vezanih uz latenciju slučajeva rabdomiolize/miopatije, gotovo pola od tih slučajeva se pojavilo 1 do 6 mjeseci nakon započinjanja liječenja s abirateronacetatom (AA).
English: Table 1: Adverse reactions identified in clinical studies and post-marketing System Organ Class
Croatian: Tablica 1: Nuspojave zabilježene u kliničkim ispitivanjima i nakon stavljanja lijeka u promet
English: There have been rare post-marketing reports of acute liver failure and hepatitis fulminant, some with fatal outcome (see section 4.8).
Croatian: Nakon stavljanja lijeka u promet rijetko su prijavljeni akutno zatajenje jetre i fulminantni hepatitis, neki sa smrtnim ishodom (vidjeti dio 4.8).
English: EU/1/11/714/002 (56 film-coated tablets) EU/1/11/714/003 (60 film-coated tablets)
Croatian: EU/1/11/714/002 (56 filmom obloženih tableta) EU/1/11/714/003 (60 filmom obloženih tableta)
English: ZYTIGA should be used with caution in patients with a history of cardiovascular disease.
Croatian: ZYTIGA se treba primjenjivati uz oprez u bolesnika s anamnezom kardiovaskularnih bolesti.
English: This enzyme is expressed in and is required for androgen biosynthesis in testicular, adrenal and prostatic tumour tissues.
Croatian: Taj je enzim aktivan i potreban za biosintezu androgena u tkivu tumora testisa, nadbubrežne žlijezde i prostate.
English: Effect of food on abiraterone acetate
Croatian: Djelovanje hrane na abirateronacetat
English: ZYTIGA is not for use in women and is contraindicated in women who are or may potentially be pregnant (see section 4.3 and 5.3).
Croatian: ZYTIGA nije namijenjena za primjenu u žena i kontraindicirana je u žena koje su trudne ili bi mogle biti trudne (vidjeti dijelove 4.3 i 5.3).
English: Therefore, ZYTIGA must not be taken with food.
Croatian: Stoga se ZYTIGA ne smije uzimati s hranom.
English: • the treatment of metastatic castration resistant prostate cancer (mCRPC) in adult men who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated (see section 5.1)
Croatian: • liječenje metastatskog karcinoma prostate rezistentnog na kastraciju (engl. metastatic castration resistant prostate cancer, mCRPC) u odraslih muškaraca koji nemaju simptome ili imaju blage simptome nakon neuspješne terapije deprivacijom androgena, u kojih kemoterapija još nije klinički indicirana (vidjeti dio 5.1)
English: A significant difference in rPFS between treatment groups was observed (see Table 4 and Figure 3).
Croatian: Primijećena je značajna razlika u rPFS između liječenih skupina (vidjeti Tablicu 4 i Sliku 3).
English: If you are not sure, talk to your doctor or pharmacist before taking this medicine.
Croatian: Ako niste sigurni, porazgovarajte s liječnikom ili ljekarnikom prije nego uzmete ovaj lijek.
English: Androgen deprivation therapies, such as treatment with LHRH analogues or orchiectomy, decrease androgen production in the testes but do not affect androgen production by the adrenals or in the tumour.
Croatian: Liječenja androgenom deprivacijom, poput liječenja analozima LHRH ili orhidektomijom, smanjuju stvaranje androgena u testisima, ali ne utječu na stvaranje androgena u nadbubrežnim žlijezdama niti u tumoru.
English: In the event of a missed daily dose of either ZYTIGA, prednisone or prednisolone, treatment should be resumed the following day with the usual daily dose.
Croatian: U slučaju da se propusti dnevna doza lijeka ZYTIGA, prednizona ili prednizolona, liječenje treba nastaviti sljedećeg dana uobičajenom dnevnom dozom.
English: - Taking ZYTIGA with food may cause side effects.
Croatian: - Uzimanje lijeka ZYTIGA s hranom može izazvati nuspojave.
English: PVdC/PE/PVC/aluminum blister of 14 film-coated tablets in a cardboard wallet.
Croatian: PVdC/PE/PVC/aluminijski blister s 14 filmom obloženih tableta u kartonskom omotu.
English: Your doctor may also prescribe other medicines while you are taking ZYTIGA and prednisone or prednisolone.
Croatian: Liječnik Vam može propisati i druge lijekove dok uzimate lijek ZYTIGA te prednizon ili prednizolon.
English: - If you forget to take ZYTIGA or prednisone or prednisolone for more than one day, talk to your doctor without delay.
Croatian: - Ako zaboravite uzeti lijek ZYTIGA ili prednizon ili prednizolon dulje od jednog dana, bez odlaganja se javite liječniku.
English: At the planned rPFS analysis there were 401 events, 150 (28%) of patients treated with ZYTIGA and 251 (46%) of patients treated with placebo had radiographic evidence of progression or had died.
Croatian: Pri planiranoj rPFS analizi bio je 401 događaj; 150 (28%) bolesnika liječenih s lijekom ZYTIGA i 251 (46%) bolesnika liječenih s placebom imalo je radiografski dokaz progresije ili je umrlo.
English: In patients with pre-existing hypokalaemia or those that develop hypokalaemia whilst being treated with ZYTIGA, consider maintaining the patient's potassium level at ≥ 4.0 mM.
Croatian: U bolesnika s postojećom hipokalemijom ili u onih kod kojih se razvije hipokalemija tijekom liječenja lijekom ZYTIGA, razmotrite održavanje razine kalija u bolesnika na ≥ 4,0 mM.
English: PVdC/PE/PVC/aluminum blister of 12 film-coated tablets in a cardboard wallet.
Croatian: PVdC/PE/PVC/aluminijski blister s 12 filmom obloženih tableta u kartonskom omotu.
English: Blood monitoring
Croatian: Krvne pretrage
English: In clinical trials, the risk for hepatotoxicity was mitigated by exclusion of patients with baseline hepatitis or significant abnormalities of liver function tests.
Croatian: U kliničkim je ispitivanjima rizik od hepatotoksičnosti umanjen činjenicom da nisu uključivani bolesnici s postojećim hepatitisom ili značajnim abnormalnostima testova jetrene funkcije.
English: Do not stop taking prednisone or prednisolone unless your doctor tells you to.
Croatian: Nemojte prestati uzimati prednizon ili prednizolon osim ako Vam to ne kaže liječnik.
English: Moreover, sections 4.3 and 4.4 of the SmPC should be amended to reflect the contraindication of the use of Xofigo (Radium-223) in combination with abiraterone acetate and prednisone/prednisolone and the increased risk for fractures and mortality in patients treated with Radium-223 in combination with abiraterone.
Croatian: Štoviše, dijelove 4.3 i 4.4 SmPC-ja potrebno je izmijeniti kako bi se uvrstila kontraindikacija primjene lijeka Xofigo (Radij-223) u kombinaciji s abirateronacetatom i prednizonom/prednizolonom i povećan rizik za frakture i smrtnost u bolesnika liječenih s radijem-223 u kombinaciji s abirateronom.
English: ZYTIGA is indicated with prednisone or prednisolone for:
Croatian: ZYTIGA je indicirana u kombinaciji s prednizonom ili prednizolonom za:
English: C-abiraterone acetate 1,000 mg, approximately 88% of the radioactive dose is recovered in faeces and approximately 5% in urine.
Croatian: C-abirateronacetata u dozi od 1000 mg, približno 88% radioaktivne doze nađe se u stolici, a približno 5% u mokraći.
English: - in combination with Ra-223 (which is used to treat prostate cancer).
Croatian: - ako imate teško oštećenje jetre. - u kombinaciji s Ra-223 (koji se koristi za liječenje raka prostate).
English: Androgen-sensitive prostatic carcinoma responds to treatment that decreases androgen levels.
Croatian: Karcinom prostate osjetljiv na androgene odgovara na liječenje kojim se snižavaju razine androgena.
English: Hepatotoxicity and hepatic impairment
Croatian: Hepatotoksičnost i oštećenje jetre
English: Efficacy was established in three randomised placebo-controlled multicentre Phase 3 clinical studies (studies 3011, 302 and 301) of patients with mHSPC and mCRPC.
Croatian: Djelotvornost je ustanovljena u tri randomizirana placebom kontrolirana multicentrična klinička ispitivanja faze 3 (ispitivanja 3011, 302 i 301), provedena u bolesnika s mHSPC-om i mCRPC-om.
English: Strong inducers of CYP3A4 (e.g., phenytoin, carbamazepine, rifampicin, rifabutin, rifapentine, phenobarbital, St John's wort [Hypericum perforatum]) during treatment are to be avoided, unless there is no therapeutic alternative.
Croatian: Primjenu snažnih induktora CYP3A4 (npr. fenitoina, karbamazepina, rifampicina, rifabutina, rifapentina, fenobarbitala, Gospine trave [Hypericum perforatum]) tijekom liječenja treba izbjegavati, osim ako nema terapijske alternative.
English: The median baseline pain score, as measured by the Brief Pain Inventory Short Form (BPI-SF) was 2.0 in both the treatment and Placebo groups.
Croatian: Brief Pain Inventory Short Form, BPI-SF) bio je 2,0 i u liječenoj i u placebo skupini.
English: Johnson & Johnson România SRL Str. Tipografilor nr. 11-15, Clădirea S-Park, Corp B3-B4, Etaj 3 013714 Bucureşti.
Croatian: Tipografilor nr. 11-15, Clădirea S-Park, Corp B3-B4, Etaj 3 013714 Bucureşti.
English: Administration with food significantly increases the absorption of abiraterone acetate.
Croatian: Primjena s hranom značajno povećava apsorpciju abirateronacetata.
English: Assess cardiac function as clinically indicated, institute appropriate management and consider discontinuation of this treatment if there is a clinically significant decrease in cardiac function (see section 4.2).
Croatian: Procijenite srčanu funkciju, prema kliničkim indikacijama, uvedite prikladno liječenje i uzmite u obzir prekid ovog liječenja, ako dođe do klinički značajnog smanjenja srčane funkcije (vidjeti dio 4.2).
English: Corticosteroid withdrawal and coverage of stress situations Caution is advised and monitoring for adrenocortical insufficiency should occur if patients are withdrawn from prednisone or prednisolone.
Croatian: Ukidanje kortikosteroida i pokrivanje stresnih situacija Preporučuje se oprez i potreban je nadzor zbog moguće adrenokortikalne insuficijencije ako bolesnik prestane uzimati prednizon ili prednizolon.
English: A significant difference in rPFS between treatment groups was observed (see Table 2 and Figure 1).
Croatian: Bila je zabilježena značajna razlika u rPFS između dvije liječene skupine (vidjeti Tablicu 2 i Sliku 1).
English: Concomitant use of a corticosteroid reduces the incidence and severity of these adverse reactions (see section 4.4).
Croatian: Istodobna primjena kortikosteroida smanjuje incidenciju i težinu tih nuspojava (vidjeti dio 4.4).
English: Failure of the liver to function (also called acute liver failure).
Croatian: Zatajenje funkcije jetre (također nazvano akutno zatajenje jetre).
English: Fluid in your legs or feet, low blood potassium, liver function test increases, high blood pressure, urinary tract infection, diarrhoea.
Croatian: Nakupljanje vode u nogama ili stopalima, niska razina kalija u krvi, povišene vrijednosti testova jetrene funkcije, visoki krvni tlak, infekcije mokraćnih puteva, proljev.
English: Before treating patients with a significant risk for congestive heart failure (e.g.a history of cardiac failure, uncontrolled hypertension, or cardiac events such as ischaemic heart disease), consider obtaining an assessment of cardiac function (e.g. echocardiogram).
Croatian: Prije liječenja bolesnika sa značajnim rizikom za nastanak kongestivnog zatajenja srca (npr. zatajenje srca, nekontrolirana hipertenzija ili srčani događaji poput ishemijske bolesti srca u anamnezi), razmotrite procjenu srčane funkcije (npr. ultrazvuk srca).
English: Based on this observed trend, the product information (SmPC Section 4.4) should be updated to reflect that rhabdomyolysis/myopathy may occur between 1 to 6 months after initiation of therapy with AA.
Croatian: Temljem tog uočenog trenda, potrebno je ažurirati informacije o lijeku (SmPC dio 4.4) kako bi se upozorilo da se rabdomioliza/miopatija mogu pojaviti 1 do 6 mjeseci nakon započinjanja liječenja s AA.
English: PSA serves as a biomarker in patients with prostate cancer.
Croatian: PSA služi kao tumorski biljeg u bolesnika s karcinomom prostate.
English: • Periodic Safety Update Report
Croatian: • Periodička izvješća o neškodljivosti
English: Caution is recommended in patients concomitantly treated with medicinal products known to be associated with myopathy/rhabdomyolysis.
Croatian: Preporučen je oprez u bolesnika koji se istodobno liječe lijekovima poznate povezanosti s miopatijom/rabdomiolizom.
English: This study enrolled chemotherapy naïve patients who were asymptomatic or mildly symptomatic and for whom chemotherapy was not yet clinically indicated.
Croatian: Ovo ispitivanje uključilo je bolesnike koji prethodno nisu primili kemoterapiju, koji su bili asimptomatski ili s blagim simptomima, te bolesnike kojima kemoterapija još nije bila klinički indicirana.
English: Tell your doctor if you are receiving medicine - used to treat heart rhythm problems (e.g. quinidine, procainamide, amiodarone and sotalol); - known to increase the risk of heart rhythm problems [e.g. methadone (used for pain relief and part of drug addiction detoxification), moxifloxacin (an antibiotic), antipsychotics (used for serious mental illnesses)].
Croatian: Recite svom liječniku ako primate lijekove - koji se koriste za liječenje problema sa srčanim ritmom (npr. kinidin, prokainamid, amiodaron i sotalol); - za koje je poznato da povisuju rizik od nastanka problema sa srčanim ritmom [npr. metadon (koristi se za ublažavanje boli i kao dio detoksikacije kod ovisnosti o drogi), moksifloksacin (antibiotik), antipsihotici (koriste se za ozbiljna mentalna oboljenja)].
English: At all evaluation time points after the initial few months of treatment, a higher proportion of patients treated with ZYTIGA remained alive, compared with the proportion of patients treated with placebo (see Figure 6).
Croatian: U svim vremenskim točkama u kojima su ocjenjivani rezultati nakon prvih mjeseci liječenja, preživio je veći udio bolesnika liječenih lijekom ZYTIGA u odnosu na udio bolesnika koji su primali placebo (vidjeti Sliku 6).
English: Dose reduction of medicinal products with a narrow therapeutic index that are metabolised by CYP2D6 should be considered.
Croatian: Treba razmotriti smanjenje doze lijekova s uskim terapijskim indeksom koji se metaboliziraju putem CYP2D6.
English: In a study to determine the effects of abiraterone acetate (plus prednisone) on a single dose of the CYP2D6 substrate dextromethorphan, the systemic exposure (AUC) of dextromethorphan was increased approximately 2.9 fold.
Croatian: U ispitivanju u kojem su se trebali utvrditi učinci abirateronacetata (uz prednizon) na jednu dozu dekstrometorfana, supstrata CYP2D6, sustavna izloženost (AUC) dekstrometorfanu povećala se približno 2,9 puta.
English: Patients were maintained on study treatments until there was PSA progression (confirmed 25% increase over the patient's baseline/nadir) together with protocol-defined radiographic progression and symptomatic or clinical progression.
Croatian: Bolesnike se održavalo na lijekovima u ispitivanju do progresije PSA (potvrđen 25%-tni porast u odnosu na bolesnikove početne vrijednosti/nadir) uz protokol definirane radiografske progresije i simptomatske ili kliničke progresije.
English: In the event of an overdose, administration should be withheld and general supportive measures undertaken, including monitoring for arrhythmias, hypokalaemia and for signs and symptoms of fluid retention.
Croatian: U slučaju predoziranja, treba zaustaviti primjenu lijeka i primijeniti opće potporne mjere, uključujući nadzor zbog moguće pojave aritmije, hipokalemije te znakova i simptoma retencije tekućine.
English: Administration of abiraterone acetate with food, compared with administration in a fasted state, results in up to a 10-fold (AUC) and up to a 17-fold (Cmax) increase in mean systemic exposure of abiraterone, depending on the fat content of the meal.
Croatian: Primjena abirateronacetata s hranom, u usporedbi s primjenom natašte, rezultira do 10 puta (AUC), odnosno do 17 puta (Cmax) većom srednjom sustavnom izloženošću abirateronu, ovisno o sadržaju masnoće u obroku.
English: As a result, reduction in organ weights and morphological and/or histopathological changes in the reproductive organs, and the adrenal, pituitary and mammary glands were observed.
Croatian: Kao rezultat toga opaženo je smanjenje mase organa te morfološke i/ili histopatološke promjene spolnih organa, hipofize, nadbubrežnih i mliječnih žlijezda.
English: For patients who develop hepatotoxicity during treatment, suspension of treatment and dose adjustment may be required (see sections 4.2 and 4.4).
Croatian: U bolesnika u kojih se tijekom liječenja razvije hepatotoksičnost možda će biti potrebno prekinuti liječenje i prilagoditi dozu (vidjeti dijelove 4.2 i 4.4).
English: The AUC to abiraterone increased by approximately 600% and the fraction of free drug increased by 80% in subjects with severe hepatic impairment compared to subjects with normal hepatic function.
Croatian: AUC abirateronu povećana je za približno 600%, te je slobodna frakcija lijeka povećana približno 80% u ispitanika s teškim oštećenjem jetre u odnosu na ispitanike s normalnom funkcijom jetre.
English: Medical castration with luteinising hormone releasing hormone (LHRH) analogue should be continued during treatment in patients not surgically castrated.
Croatian: Medicinska kastracija analogom hormona koji oslobađa luteinizirajući hormon (engl. luteinising hormone releasing hormone, LHRH) mora se nastaviti tijekom liječenja u bolesnika koji nisu kastrirani operativnim zahvatom.