FrancophonIA/ELRC3.0 huggingface dataset:
English: Administration of indinavir with a meal high in calories, fat, and protein resulted in a blunted and reduced absorption with an approximate 80 % reduction in AUC and an 86 % reduction in Cmax.
Maltese: Meta indinavir ngħata ma' ikla b'ħafna kaloriji, xaħam u proteini, l-assorbiment tiegħu tnaqqas bejn wieħed u ieħor bi 80 % fl-AUC u tnaqqas bi 86 % f' Cmax.
English: increases in MCV, decreases in neutrophils increased spontaneous bleeding in patients with haemophilia, anemia including acute haemolytic anaemia, thrombocytopenia (see section 4.4).
Maltese: b'anemija inkluż anemija emolitika akuta, bi tromboċitopenija (ara sezzjoni 4.4).
English: Herbal preparations containing St. John's wort are contraindicated with Crixivan.
Maltese: John's wort mhumiex rakkomandati ma' Crixivan.
English: The recommendation is based on limited pharmacokinetic data (see section 5.2).
Maltese: Din ir-rakkomandazzjoni hija bbażata fuq dejta farmakokinetika limitata (ara sezzjoni 5.2).
English: In HIV-infected paediatric patients, the pharmacokinetic parameters of indinavir in apple sauce were: AUC0-8hr of 26,980 nM*h; peak plasma concentration of 13,711 nM; and plasma concentration at 8 hours post dose of 146 nM.
Maltese: F'pazjenti tfal infettati blHIV, il-parametri farmakokinetiċi ta' indinavir fiz-zalza tat-tuffieħ kienu : AUC0-8hr ta' 26980 nM*h; l-ogħla konċentrazzjonijiet fil-plażma ta' 13711 nM; u konċentrazzjonijiet tal-plażma 8 sigħat wara ddoża ta' 146 nM.
English: Indinavir Cmin: ↑ 49 % (Relative to Indinavir 800 mg TID alone)
Maltese: Cmin Indinavir: ↑ 49% (Għal Indinavir 800 mg TID waħdu)
English:  atorvastatin concentration Atorvastatin is less dependent on CYP3A4 for metabolism than lovastatin or simvastatin
Maltese:  konċentrazzjoni atorvastatin Atorvastatin huwa inqas dipendenti fuq CYP3A4 għal metaboliżmu minn lovastatin jew simvastatin
English: CRIXIVAN with or without ritonavir should not be administered concurrently with amiodarone, terfenadine, cisapride, astemizole, quetiapine, alprazolam, triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see Table 1 and 2 below), pimozide, ergot derivatives, simvastatin or lovastatin.
Maltese: CRIXIVAN bi jew mingħajr ritonavir ma għandux jingħata fl-istess ħin ma' amiodarone, terfenadine, cisapride, astemizole, quetiapine, alprazolam, triazolam, midazolam mogħti mill-ħalq (għal twissija fuq midazolam mogħti b'mod parneterali, ara t-Tabella 1 u 2 taħt), pimozide, derivattivi ergot, simvastatin jew lovastatin.
English: HMG-CoA REDUCTASE INHIBITORS
Maltese: Il-kombinazzjoni mhijiex rakkomandata
English: No carcinogenicity was noted in mice at the maximum tolerated dose, which corresponded to a systemic exposure approximately 2 to 3 times higher than the clinical exposure.
Maltese: Ma ġietx innutata karċinoġeniċita` fil-ġrieden bid-doża massima tollerata, li kien jikkorrispondi għal espożizzjoni sistemika bejn wieħed u ieħor 2 jew 3 ogħla mill-espożizzjoni klinika.
English: Indinavir and norethindrone/ethinyl estradiol 1/35 can be coadministered without dose adjustment.
Maltese: Indinavir u norethindrone/ethinyl estradiol 1/35 jistgħu jingħataw flimkien mingħajr aġġustament fiddoża.
English: Indinavir Cmin : ↓ 39 %
Maltese: Cmin Ritonavir: 39%
English: Erythromycin, Itraconazole Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of erythromycin and itraconazole.
Maltese: Indinavir u ritonavir jinibixxu CYP3A4 u b'konsegwenza t'hekk huma mistennija li jżidu l-konċentrazzjonijiet talplażma ta' erythromycin and itraconazole.
English: Each hard capsule contains indinavir sulphate corresponding to 200 mg of indinavir.
Maltese: Kull kapsula iebsa fiha indinavir sulphate li jikkorrispondi għal 200 mg ta' indinavir.
English: The mean indinavir plasma AUC0-8hr at week 30-32 of gestation (n = 11) was 9,231 nMhr, which is 74 % (95 % CI: 50 %, 86 %) lower than that observed 6 weeks postpartum.
Maltese: IL-medja għall-plażma AUC0-8hr ta' indinavir fit-30-32 ġimgħa tat-tqala (n=11) kienet 9,231 nM∗hr, li hi 74% (95% CI: 50%, 86%) inqas minn dik osservata 6 ġimgħat wara l-ħlas.
English: Cross resistance
Maltese: Resistenza msallba
English: Boosted indinavir (indinavir with ritonavir) may have additive pharmacokinetic effects on substances that share the CYP3A4 pathway as both ritonavir and indinavir inhibit the cytochrome P450 enzyme CYP3A4.
Maltese: Indinavir imsaħħaħ (indinavir ma' ritonavir) jista' jkollu effetti farmakokinetiċi addittivi fuq sustanzi li jaqsmu l-istess mogħdija ta' CYP3A4 minħabba li kemm ritonavir kif ukoll indinavir jinibixxu lenzim ta' cytochrome P450, CYP3A4.
English: Efavirenz AUC: 
Maltese: AUC u Cmin Efavirenz:
English: Amlodipine AUC0-24hr:  80 % Indinavir/ritonavir AUCs: 
Maltese: AUC0-24hr Amlodipine:  80%
English: Nephrolithiasis and tubulointerstitial nephritis
Maltese: Nefrolitjasis u nefrajtis tubulointerstizjali
English: This overall safety profile remained similar for 107 patients treated with CRIXIVAN monotherapy or in combination with NRTI(s) for up to 48 weeks.
Maltese: Dan il-profil globali ta' sigurta` kien simili wkoll għal 107 pazjenti kkurati bi CRIXIVAN waħdu jew flimkien ma' NRTI(s) għal perjodu sa 48 ġimgħa.
English: PIs
Maltese: Tqala
English: Indinavir AUC:  31 % Indinavir Cmin:  40 %
Maltese: AUC Indinavir: ↓ 20% Cmin Indinavir: ↑ 29%
English: Batch
Maltese: Jekk
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Maltese: Pazjenti li kellhom minn qabel mard fil-fwied li jinkludi epatite attiva kronika għandhom frekwenza ogħla ta' anormalitajiet fil-funzjoni tal-fwied waqt it-terapija kombinata antiretrovirali u għandhom ikunu taħt osservazzjoni skond il-prattika normali.
English: This medicine contains lactose (type of sugar).
Maltese: Din il-mediċina fiha lactose (tip ta' zokkor).
English: Amprenavir 1,200 mg BID (Indinavir 1,200 mg BID)
Maltese: (Indinavir 1200 mg BID)
English: HIV 1 patient isolates with reduced susceptibility to indinavir expressed varying patterns and degrees of cross-resistance to a series of diverse HIV PIs, including ritonavir and saquinavir.
Maltese: L-iżolati tal-pazjenti bl-HIV-1 b'suxxettibilita` mnaqqsa għal indinavir kellhom varjeta` ta' forom u livelli ta' reżistenza li tintiret lil serje ta' HIV PIs differenti, inkluż ritonavir u saquinavir.
English: Indinavir inhibits recombinant HIV-1 and HIV-2 protease with an approximate tenfold selectivity for HIV-1 over HIV-2 proteinase.
Maltese: Mekkaniżmu ta' azzjoni Indinavir jinibixxi l-protease rikombinanti ta' l-HIV-1 u l-HIV-2 b'selettivita` bejn wieħed u ieħor ta'
English: INSTRUCTIONS ON USE
Maltese: INIBITURI REDUCTASE
English: Interaction unknown.
Maltese: interazzjoni formali.
English: • itraconazole, ketoconazole - used to treat fungal infections
Maltese: • itraconazole, ketoconazole - jintużaw biex jikkuraw infezzjonijiet bil-fungu
English: Metabolism of pravastatin and fluvastatin is not dependent on CYP3A4.
Maltese: Interazzjoni mhux studjata Il-metaboliżmu ta' pravastatin u fluvastatin mhuwiex dipendenti fuq CYP3A4.
English: Interactions between indinavir/ritonavir and other medicinal products are listed in the tables below (increase is indicated as “↑”, decrease as “↓”, no change (≤ +/- 20 %) as “↔”, single dose as “SD”, once daily as “QD”, twice daily as “BID”, three times daily as “TID”, and four times daily as "QID").
Maltese: Interazzjonijiet bejn indinavir/ritonavir u prodotti mediċinali oħrajn huma elenkati fit-tabelli taħt (żieda hija indikata bħala “↑”, tnaqqis bħala “↓”, ebda bidla (≤ +/- 20%) bħala “↔”, doża waħda bħala “SD”, darba kuljum bħala “QD”, darbtejn kuljum bħala “BID”, tliet darbiet kuljum bħala “TID” u erba' darbiet kuljum bħala "QID").
English: Synergistic antiretroviral activity was observed when human T-lymphoid cells infected with the LAI variant of HIV-1 were incubated with indinavir and either zidovudine, didanosine, or NNRTIs.
Maltese: T-limfojdi infettati bil-varjant LAI ta' l-HIV-1 kienu inkubati b'indinavir u jew zidovudine, didanosine, jew NNRTIs.
English: In addition, when CRIXIVAN is given at the same time as the medicine ritonavir: Do not take either CRIXIVAN or ritonavir:
Maltese: Tiħux la CRIXIVAN u lanqas ritonavir:
English: Nephrolithiasis, including flank pain with or without haematuria (including microscopic haematuria), has been reported in approximately 10 % (252/2,577) of patients receiving CRIXIVAN in clinical trials at the recommended dose compared to 2.2 % in the control arms.
Maltese: Nefrolitjasi li tinkludi uġigħ fil-ġenb b'ematurja jew mingħajrha (li tinkludi ematurja mikroskopika), ġiet irrappurtata f'madwar 10 % (252/2,577) tal-pazjenti li kienu qed jirċievu CRIXIVAN fi provi kliniċi fid-dożi rrakkomandati meta mqabbla ma' 2.2 % fil-fergħat ta' kontroll.
English: Nephrolithiasis occurred in approximately 10 % of patients treated with the recommended (unboosted) dose of CRIXIVAN in a pooled analysis of controlled clinical trials (see also below table and in section 4.4).
Maltese: Nefrolitjasi seħħet f'madwar 10 % tal-pazjenti kkurati bid-doża (mhux msaħħa) rrakkomandata ta' CRIXIVAN f'analiżi pooled ta' provi kliniċi kkontrollati (ara wkoll it-tabella hawn taħt u f'sezzjoni 4.4).
English: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthroses, in haemophiliac patients type A and B treated with PIs.
Maltese: Kien hemm rapporti ta' żieda fid-dmija, inkluż ematomi spontanji tal-ġilda u emartrożi, f'pazjenti emofiliċi ta' tipi A u B kkurati bil-PIs.
English: Indinavir inhibits CYP3A4 and as a result is expected to markedly increase the plasma concentrations of these HMG-CoA reductase inhibitors, which are highly dependent on CYP3A4 metabolism.
Maltese: Indinavir jinibixxi CYP3A4 u għalhekk huwa mistenni li jżid sostanzjalment il konċentrazzjonijiet tal-plażma ta' dawn l-inibituri reductase ta' HMG-CoA, li huma dipendenti ferm fuq il-metaboliżmu ta' CYP3A4.
English: Coadministration of ritonavir and ketoconazole caused an increased incidence of gastrointestinal and hepatic adverse events.
Maltese: L-għoti fl-istess ħin ta' ritonavir u ketoconazole ikkawża żieda fl-inċidenza ta' episodji avversi gastrointestinali u epatiċi.
English: Frequency Adverse reactions CRIXIVAN
Maltese: Reazzjonijiet avversi CRIXIVAN
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Maltese: Għalkemm l-etjoloġija titqies li hi multifattorjali (inkluż l-użu ta' kortikosterojdi, il-konsum ta' lalkolħol immunosoppressjoni severa, indiċi ogħla tal-massa tal-ġisem), ġew irrapurtati każijiet ta' ostejonekrożi speċjalment f'pazjenti b'mard avvanzat ta' l-HIV u/jew espożizzjoni fit-tul għat-terapija antiretrovirali kombinata (CART).
English: Distribution Indinavir was not highly bound to human plasma proteins (39 % unbound).
Maltese: Indinavir mhux marbut b'mod qawwi mal-proteini tal-bniedem fil-plażma (39 % mhux marbuta).
English: The combination of rifampicin and CRIXIVAN with concomitant low-dose ritonavir is contraindicated (see section 4.3).
Maltese: Il-kombinazzjoni ta' rifampicin u CRIXIVAN ma' doża baxxa ta' ritonavir li tingħata fl-istess ħin hija kontraindikata (ara sezzjoni 4.3).
English: Caution is advised.
Maltese: episodji avversi.
English: A boosted dose of 800 mg indinavir/100 mg ritonavir twice daily results in increased risk of adverse events.
Maltese: Doża msaħħa ta' 800 mg indinavir/100 mg ritonavir darbtejn kuljum tirriżulta f'riskju miżjud ta'
English: The suggestion is based on limited published data (see section 5.2).
Maltese: Is-suġġeriment huwa bbażat fuq data ppubblikata limitata (ara sezzjoni 5.2).
English: Indinavir alone or in combination with nucleoside analogues (zidovudine/stavudine and lamivudine) has been shown to delay clinical progression rate compared with nucleoside analogues and to provide a sustained effect on viral load and CD4 count.
Maltese: Intwera li indinavir waħdu jew flimkien ma' analogi nukleosidi (zidovudine/stavudine u lamivudine) idawwar il-progressjoni klinika meta mqabbel ma' analogi nukleosidi u jipprovdi effett sostnut fuq l ammont ta' virus u l-għadd CD4.
English: At steady state following a dose regimen of 800 mg every 8 hours, HIV-seropositive adult patients in one study achieved geometric means of: AUC0-8h of 27,813 nM*h (90 % confidence interval = 22,185, 34,869), peak plasma concentrations 11,144 nM (90 % confidence interval = 9,192, 13,512) and plasma concentrations at 8 hours post dose 211 nM (90 % confidence interval = 163,
Maltese: HIV-seropożittivi fi studju wieħed kellhom medji ġeometriċi ta' : AUC0-8h ta' 27813 nM*h (intervall tad-90 % = 22185, 34869), l-ogħla konċentrazzjonijiet tal-plażma 11144 nM (intervall tad-90 % = 9192, 13512) u l-ogħla konċentrazzjonijiet tal-plażma 8 sigħat wara d-doża 211 nM (intervall tad-90 % = 163, 274).
English: • indigestion or diarrhoea
Maltese: • rimettar • dijarea
English: - rifampicin - an antibiotic used to treat infections - cisapride - used for gut problems - amiodarone - used for heart rhythm problems - pimozide - used for some mental health problems - lovastatin or simvastatin - used to lower cholesterol - St. John's wort (Hypericum perforatum) - a herbal medicine used for depression - ergot tartramine (with or without caffeine) - used for migraines - astemizole or terfenadine - antihistamines used for hay fever and other allergies - quetiapine - used for some mental illnesses such as schizophrenia, bipolar disorder and major depressive disorder - alprazolam, triazolam and midazolam (by mouth) - used to make you calmer or help you sleep.
Maltese: - ergot tartramine (bil-kafeina jew mingħajrha) - jintuża għall-emigranji - astemizole jew terfenadine - antiistamini li jintużaw għall-hay fever u allerġiji oħrajn - quetiapine - użat għal xi mard mentali bħall-iskizofrenja, disturb bipolari u disturb ta' dipressjoni maġġuri - alprazolam, triazolam u midazolam (mill-ħalq) - jintużaw biex jikkalmawk jew jgħinuk torqod.
English: Between 800-mg and 1,000-mg dose levels, the deviation from dose-proportionality is less pronounced.
Maltese: Bejn il-livelli ta' doża minn 800 mg u 1,000 mg, id-devjazzjoni mill-proporzjonalita`
English: CALCIUM CHANNEL BLOCKERS Diltiazem 120 mg QD (Indinavir/ritonavir 800/100 BID)
Maltese: Diltiazem 120 mg QD (Indinavir/ritonavir 800/100
English: The use of indinavir/ritonavir with quinidine is contraindicated.
Maltese: L-użu ta' indinavir/ritonavir ma' quinidine mhuwiex rakkomandat.
English: The interaction of indinavir or indinavir/ritonavir with pravastatin or fluvastatin is not known (see section 4.5).
Maltese: L-interazzjoni ta' indinavir jew indinavir/ritonavir ma' pravastatin jew fluvastatin mhijiex magħrufa (ara sezzjoni 4.5).
English: • CRIXIVAN - one 400 mg capsules (400 mg) - taken twice a day.
Maltese: CRIXIVAN - kapsula waħda ta' 400 mg (400 mg) - tittieħed darbtejn kuljum.
English: Saquinavir 1,200 mg SD (soft gel capsule formulation) (Indinavir 800 mg TID)
Maltese: Saquinavir 1200 mg SD (formulazzjoni ta' kapsula b'ġell artab)
English: Interaction with indinavir/ritonavir not studied
Maltese: L-interazzjoni indinavir/ritonavir ma ġietx studjata
English: Saquinavir 800 mg SD (soft gel capsule formulation) (Indinavir 800 mg TID)
Maltese: Saquinavir 800 mg SD (formulazzjoni ta' kapsula b'ġell artab)
English: In vitro studies with human liver microsomes indicated that CYP3A4 is the only P450 isozyme that plays a major role in the oxidative metabolism of indinavir.
Maltese: Studji in vitro b'mikrożomi tal-fwied talbniedem indikaw li CYP3A4 huwa l-unika iżozima P450 li għandha sehem maġġuri fil-metaboliżmu ossidativ ta' indinavir.
English: • The capsules are printed with printing ink containing indigo carmine (E 132).
Maltese: • Il-kapsuli huma stampati b'linka tal-istampar li fiha indigo carmine (E 132).
English: CALCIUM CHANNEL BLOCKERS Dihydropyridine: e.g., felodipine, nifedipine, nicardipine
Maltese: TAL-KALĊJU Dihydropyridine: eż., felodipine,
English: Distribution of indinavir across the placental barrier was significant in rats, but limited in rabbits.
Maltese: Id-distribuzzjoni ta' indinavir mill-barriera tal-plaċenta kien sinifikanti, imma kien limitat fil-fniek.
English: PDE5 INHIBITOR Sildenafil 25 mg SD (Indinavir 800 mg TID)
Maltese: INIBITUR PDE5 Sildenafil 25 mg SD
English: Indinavir AUC: ↓ 32 % Indinavir Cmin: ↓ 40 % (Relative to Indinavir 800 mg TID alone)
Maltese: AUC Indinavir ↓ 34% Indinavir Cmin : ↓ 39% (Għal Indinavir 800 mg TID waħdu)
English: Interactions and dose recommendations with other medical products - INDINAVIR BOOSTED WITH RITONAVIR.
Maltese: Interazzjonijiet u rakkomandazzjonijiet dwar id-doża ma' prodotti mediċinali oħrajn - INDINAVIR IMSAĦĦAĦ MA' RITONAVIR.
English: Renal clearance (116 mL/min) of indinavir is concentration-independent over the clinical dose range.
Maltese: It-tneħħija permezz tal-kliewi (116 mL/min) ta' indinavir tiddependi mill konċentrazzjoni fuq il-medda tad-doża.
English: Interaction with indinavir/ritonavir not studied Ritonavir induces oxidation by CYP2C9 and glucuronidation and as a result is expected to decrease the plasma concentrations of anticonvulsants.
Maltese: Ritonavir jinduċi l-ossidazzjoni minn CYP2C9 u glukuronidazzjoni u b'konsegwenza huwa mistenni li jnaqqas ilkonċentrazzjoni tal-plażma ta' antikonvulsanti.
English: If CRIXIVAN with ritonavir is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Maltese: Jekk CRIXIVAN jingħata flistess ħin ma' midazolam parenterali, dan għandu jsir f'taqsima ta' kura intensiva b'monitoraġġ kliniku millqrib fil-każ ta' depressjoni respiratorja u/jew sedazzjoni mtawwla.
English: A normal (acidic) gastric pH may be necessary for optimum absorption of indinavir whereas acid rapidly degrades didanosine which is formulated with buffering agents to increase pH.
Maltese: Jista' jkun hemm bżonn ta' pH gastriku normali (aċidiku) għal assorbiment ottimu ta' indinavir filwaqt li l-aċidu jiddegrada rapidament didanosine li hija fformulata b'sustanzi ta' buffer sabiex iżidu l-pH.
English: • Two 400 mg capsules (800 mg) - taken three times a day (every 8 hours).
Maltese: Żewġ kapsuli ta' 400 mg (800 mg) - jittieħdu tliet darbiet kuljum (kull 8 sigħat).
English: Data from published studies suggest that CRIXIVAN 400 mg in combination with ritonavir 100 mg, both administered orally twice daily, may be an alternative dosing regimen.
Maltese: Data mill-istudji ppubblikati tissuġġerixxi li CRIXIVAN 400 mg f'kombinazzjoni ma' ritonavir 100 mg, it-tnejn li huma mogħtija mill-ħalq darbtejn kuljum, jista' jkun reġimen ta' dożaġġ alternattiv.
English: EXPIRY DATE
Maltese: mg TID
English: CRIXIVAN 200 mg hard capsules Indinavir
Maltese: CRIXIVAN 200 mg kapsuli iebsin Indinavir
English: • The other ingredients are anhydrous lactose, magnesium stearate, gelatin and titanium dioxide (E 171).
Maltese: • Is-sustanzi l-oħra huma anhydrous lactose, magnesium stearate, ġelatina u titanium dioxide (E
English: Indinavir AUC and Cmin: ↔ (Relative to Indinavir 800 mg TID alone*)
Maltese: AUC u Cmin Indinavir: ↔ (Għal Indinavir 800 mg TID waħdu)
English: Vardenafil dose should not exceed a maximum of 2.5 mg in a 24-hour period in patients receiving concomitant indinavir therapy.
Maltese: Doża ta' Vardenafil ma għandhiex taqbeż massimu ta' 2.5 mg f'perjodu ta' 24 siegħa f'pazjenti li jirċievu terapija ta' indinavir fl-istess ħin.
English: Lactose
Maltese: KALĊJU
English: Caution should be used with coadministration of CRIXIVAN and parenteral midazolam.
Maltese: Għandha tingħata kawtela meta CRIXIVAN u midazolam parenterali jingħataw flimkien.
English: ANTI-INFECTIVES Antiretrovirals Amprenavir
Maltese: Antiretrovirali
English: CRIXIVAN 200 mg hard capsules
Maltese: CRIXIVAN 200 mg kapsuli ibsin
English: CRIXIVAN 400 mg hard capsules
Maltese: CRIXIVAN 400 mg kapsuli ibsin
English: In one published study, 20 HIV-infected patients with undetectable plasma viral load (< 200 copies/mL) receiving indinavir 800 mg every 8 hours were switched in an open, cross-over design to indinavir/ritonavir 400/100 mg every 12 hours.
Maltese: Fi studju wieħed ippubblikat, 20 pazjent infettat bl-HIV b'tagħbija virali tal-plażma li ma tistax tiġi ntraċċata (<200 kopja/ml) li kienu qegħdin jirċievu 800 mg kull 8 sigħat inqelbu għal disinn miftuħ, cross-over għal indinavir/ritonavir 400/100 mg kull 12-il siegħa.
English: CRIXIVAN 400 mg hard capsules indinavir
Maltese: CRIXIVAN 400 mg kapsuli iebsin Indinavir
English: Please see ‘Do not take CRIXIVAN' and ‘Do not take either CRIXIVAN or ritonavir' above under Section 2 for an important list of medicines that you must not combine with CRIXIVAN.
Maltese: Jekk jogħġbok ara ‘Tiħux CRIXIVAN' u ‘Tiħux la CRIXIVAN u lanqas ritonavir' fuq taħt Sezzjoni 2 għal-lista importanti ta' mediċini li inti m'għandekx tieħu flimkien ma' CRIXIVAN.
English: The pharmacokinetics of indinavir (400 mg) with ritonavir (100 mg) dosed twice daily was examined in two studies.
Maltese: Il-farmakokinetika ta' indinavir (400 mg) ma' ritonavir (100 mg) iddożat darbtejn kuljum kienet eżaminata f'żewġ studji.
English: Careful monitoring of therapeutic and adverse effects is recommended when buspirone is concomitantly administered with indinavir/ritonavir.
Maltese: Huwa rrakkomandat monitoraġġ attent ta' l-effetti terapewtiċi u avversi meta buspirone jingħata fl-istess ħin ma' indinavir/ritonavir.
English: Rifampicin is a strong CYP3A4 inducer and has been shown to cause a 92 % decrease in indinavir AUC which can result in virological failure and resistance development.
Maltese: Rifampicin huwa induttur b'saħħtu ta' CYP3A4 u ntwera li jikkawża tnaqqis ta' 92% fl-AUC ta' indinavir li tista' tirriżulta fi ħsara viroloġika u f'reżistenza għall-iżvilupp.
English: Co-administration of quetiapine with indinavir is contraindicated (see section 4.3).
Maltese: L-għoti fl-istess ħin ta' quetiapine ma' indinavir huwa kontraindikat (ara sezzjoni 4.3).
English: Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered.
Maltese: Għandu jitqies tnaqqis fid-doża ta' CRIXIVAN għal 600 mg kull 8 sigħat.
English: There is no significant effect of unboosted indinavir on methadone AUC (see Table 1 above).
Maltese: Ma hemm ebda effett sinjifikanti ta' indinavir mhux imsaħħaħ fuq l-AUC tal-methadone (ara t-Tabella 1 fuq).
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Maltese: Pazjenti b'epatite B jew C kronika u kkurati b'terapija mħallta antiretrovirali għandhom riskju ogħla ta' reazzjonijiet negattivi qawwija u potenzjalment fatali fil-fwied.
English: Effects on viral load were consistently more pronounced in patients treated with indinavir in combination with nucleoside analogues, but the proportion of patients with serum viral RNA below the limit of quantification (500 copies/mL) varied between studies, at week 24 from 40 % to more than 80 %.
Maltese: L-effetti fuq l-ammont ta' virus kienu iktar qawwija b'mod konsistenti f'pazjenti kkurati b'indinavir flimkien ma' analogi nukleosidi, imma l-proporzjon ta' pazjenti bis-serum virali RNA taħt il-livell minimu ta' kwantifikazzjoni (500 kopji/mL) kien ivarja minn studju għal ieħor, fl-24 ġimgħa minn 40 % sa iktar minn 80 %.
English:  dihydropyridine calcium channel blocker concentration
Maltese: Għalxiex jintuża CRIXIVAN
English: Tel.: +48 22 549 51 00 msdpolska@merck.com
Maltese: Tel.: +421 2 58282010 dpoc_czechslovak@merck.com
English: CRIXIVAN 200 mg - packs of 180, 270 and 360 capsules - Bottle label
Maltese: TAGĦRIF LI GĦANDU JIDHER FUQ IL-PAKKETT TA' BARRA CRIXIVAN 200 mg - pakketti ta' 180, 270 u 360 kapsula - Kartuna ta' barra