FrancophonIA/ELRC3.0 huggingface dataset:
English: Nervous system disorders headache convulsion, syncope, tremor, hypertonia3, paraesthesia, somnolence, dizziness brain oedema, encephalopathy4, extrapyramidal disorder5, neuropathy peripheral, ataxia, hypoaesthesia, dysgeusia hepatic encephalopathy, Guillain-Barre syndrome, nystagmus
Croatian: Poremećaji živčanog sustava glavobolja konvulzije, sinkopa, tremor, hipertonija3, parestezija, somnolencija, omaglica edem mozga, encefalopatija4, ekstrapiramidni poremećaj5, periferna neuropatija, ataksija, hipoestezija, disgeuzija jetrena encefalopatija, GuillainBarréov sindrom, nistagmus
English: The placeboadjusted mean maximum increases in QTc from baseline after 800, 1200 and 1600 mg of voriconazole were 5.1, 4.8, and 8.2 msec, respectively and 7.0 msec for ketoconazole 800 mg. No subject in any group had an increase in QTc of ≥60 msec from baseline.
Croatian: Srednja vrijednost maksimalnog produljenja QTcintervala u odnosu na početne vrijednosti, korigirana za placebo, iznosila je 5,1 ms kod primjene doze vorikonazola od 800 mg, 4,8 ms kod primjene doze od 1200 mg te 8,2 ms kod primjene doze od 1600 mg, dok je kod primjene ketokonazola u dozi od 800 mg produljenje iznosilo 7,0 ms.
English: Co-administration with ergot alkaloids (ergotamine, dihydroergotamine), which are CYP3A4 substrates, since increased plasma concentrations of these medicinal products can lead to ergotism (see section 4.5).
Croatian: Istodobna primjena s ergot alkaloidima (ergotamin, dihidroergotamin) koji su supstrati CYP3A4, jer porast njihove koncentracije u plazmi može dovesti do ergotizma (vidjeti dio 4.5.)
English: Inhibitors or inducers of these isoenzymes may increase or decrease voriconazole plasma concentrations, respectively, and there is potential for voriconazole to increase the plasma concentrations of substances metabolised by these CYP450 isoenzymes.
Croatian: Inhibitori ovih izoenzima mogu povisiti, a njihovi induktori sniziti koncentraciju vorikonazola u plazmi, a vorikonazol potencijalno može povećati plazmatske koncentracije lijekova koji se metaboliziraju putem navedenih izoenzima citokroma P450.
English: including A. flavus, A. fumigatus, A. terreus, A. niger, A. nidulans, Candida spp., including C. albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis and limited numbers of C. dubliniensis, C. inconspicua and C. guilliermondii, Scedosporium spp., including S. apiospermum, S. prolificans and Fusarium spp.
Croatian: Klinička je djelotvornost, definirana kao djelomičan ili potpun odgovor, dokazana za vrste iz roda Aspergillus uključujući A. flavus, A. fumigatus, A. terreus, A. niger, A. nidulans, vrste iz roda Candida uključujući C. albicans, C. glabrata, C. krusei, C.parapsilosis i C. tropicalis i za ograničen broj C. dubliniensis, C. inconspicua i C. guilliermondii, vrste iz roda Scedosporium uključujući S. apiospermum, S. prolificans te vrste iz roda Fusarium.
English: Frequent monitoring for adverse reactions and toxicity related to methadone, including QTc prolongation, is recommended.
Croatian: Preporučuju se česte kontrole zbog mogućih nuspojava i toksičnosti vezanih uz metadon, uključujući produljenje QT intervala.
English: Endocrine disorders adrenal insufficiency, hypothyroidism hyperthyroidism
Croatian: Endokrini poremećaji insuficijencija nadbubrežnih žlijezda, hipotireoidizam hipertireoidizam
English: Psychiatric disorders depression, hallucination, anxiety, insomnia, agitation, confusional state
Croatian: Psihijatrijski poremećaji depresija, halucinacije, anksioznost,
English: • Sulfonylureas (e.g., tolbutamide, glipizide and glyburide) (used for diabetes)
Croatian: • preparate sulfonilureje (tj. tolbutamid, glipizid, i gliburid) (koriste se za liječenje šećerne bolesti)
English: In an oral multiple dose study, AUCτ was similar in subjects with moderate hepatic cirrhosis (Child-Pugh B) given a maintenance dose of 100 mg twice daily and subjects with normal hepatic function given 200 mg twice daily.
Croatian: U ispitivanju primjene višekratnih peroralnih doza AUCτ je bio podjednak u ispitanika s umjerenom cirozom jetre (Child-Pugh stadij B) koji su dobivali dozu održavanja od 100 mg dvaput na dan i u ispitanika s normalnom jetrenom funkcijom koji su primali dozu od 200 mg dvaput na dan.
English: Voriconazole (N=125)
Croatian: Vorikonazol (N=125)
English: Immunosuppressants [CYP3A4 substrates] Sirolimus (2 mg single dose)
Croatian: Imunosupresivi [supstrati CYP3A4] Sirolimus (jedna doza od 2 mg)
English: Frequent monitoring for opiateassociated adverse reactions may be necessary (see section 4.5).
Croatian: Možda će biti potrebne česte kontrole zbog mogućih nuspojava povezanih s opijatima (vidjeti dio 4.5).
English: Therapy must be initiated with the specified loading dose regimen of either intravenous or oral voriconazole to achieve plasma concentrations on Day 1 that are close to steady state.
Croatian: Liječenje mora započeti primjenom odgovarajuće udarne doze intravenskog ili peroralnog oblika voriknazola, kako bi se već prvog dana dosegle koncentracije lijeka u plazmi približne onima u stanju dinamičke ravnoteže.
English: Voriconazole should be administered with caution in patients with concomitant medication that is known to prolong QTc interval.
Croatian: Vorikonazol treba primjenjivati s oprezom u bolesnika koji istodobno primaju lijek koji produljuju QTcinterval.
English: - The other ingredient is sulfobutylether beta cyclodextrin sodium.
Croatian: - Drugi sastojaci su: natrijev sulfobutileter beta ciklodekstrin.
English: Pharmacotherapeutic group: Antimycotics for systemic use, - triazole derivatives ATC code: J02AC03
Croatian: Farmakoterapijska skupina: Antimikotici za sistemsku primjenu, derivati triazola.
English: The most commonly reported adverse reactions were visual impairment, pyrexia, rash, vomiting, nausea, diarrhoea, headache, peripheral oedema liver function test abnormal, respiratory distress and abdominal pain.
Croatian: Najčešće prijavljene nuspojave bile su oštećenje vida, pireksija, osip, povraćanje, mučnina, proljev, glavobolja, periferni edem, abnormalne vrijednosti testova funkcije jetre, respiratorni distres i bol u abdomenu.
English: Hikma Italia S.p.A. Tél/Tel: + 39 0382 1751801
Croatian: Tél/Tel: + 39 0382 1751801
English: If patients are unable to tolerate treatment, reduce the intravenous dose by 1 mg/kg steps.
Croatian: Ako bolesnik ne podnosi liječenje, treba smanjivati dozu u koracima od 1 mg/kg.
English: Sulphobutylether beta cyclodextrin sodium (SBECD)
Croatian: Natrijev sulfobutileter beta ciklodekstrin (SBECD)
English: Liver function test abnormalities may be associated with higher plasma concentrations and/or doses.
Croatian: Moguće je da su poremećaji testova funkcije jetre povezani s višim koncentracijama vorikonazola u plazmi i/ili višim dozama.
English: Cardiac disorders arrhythmia supraventricular, tachycardia, bradycardia ventricular fibrillation, ventricular extrasystoles, ventricular tachycardia, electrocardiogram QT prolonged, supraventricular tachycardia torsades de pointes, atrioventricular block complete, bundle branch block, nodal rhythm
Croatian: Srčani poremećaji supraventrikularna aritmija, tahikardija, bradikardija ventrikularna fibrilacija, ventrikularne ekstrasistole, ventrikularna tahikardija, produljenje QTintervala na EKGu, supraventrikularna tahikardija torsades de pointes, kompletna atrioventrikularn a blokada, blokada provodnog sustava srca, nodalni ritam
English: Voriconazole was investigated as secondary prophylaxis in an open-label, non-comparative, multicenter study of adult allogeneic HSCT recipients with prior proven or probable IFI.
Croatian: Vorikonazol je ispitan kao sekundarna profilaksa u otvorenom, neusporednom, multicentričnom ispitivanju u odraslih primatelja alogene HSCT s prethodnom dokazanom ili vjerojatnom invazivnomgljivičnom infekcijom.
English: 8 mg/kg twice a day
Croatian: 8 mg/kg dvaput na dan
English: Co-administration of voriconazole with everolimus is not recommended because voriconazole is expected to significantly increase everolimus concentrations.
Croatian: Ne preporučuje se istodobna primjena vorikonazola s everolimusom jer se očekuje da će vorikonazol značajno povisiti koncentracije everolimusa.
English: Voriconazole may be coadministered with efavirenz if the voriconazole maintenance dose is increased to 400 mg BID and the efavirenz dose is decreased to 300 mg QD.
Croatian: Vorikonazol se smije primijeniti istodobno s efavirenzom ako se doza održavanja vorikonazola povisi na 400 mg BID, a doza efavirenza snizi na 300 mg QD.
English: Voriconazole Hikma has a moderate influence on the ability to drive and use machines.
Croatian: Hikma umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: There have been post-marketing reports of pancreatitis in paediatric patients.
Croatian: Nakon stavljanja lijeka u promet u pedijatrijskih su bolesnika prijavljeni slučajevi pankreatitisa.
English: Voriconazole N=224
Croatian: Vorikonazol N=224
English: When initiating voriconazole in patients already on tacrolimus, it is recommended that the tacrolimus dose be reduced to a third of the original dose and tacrolimus level carefully monitored.
Croatian: Kad se započinje primjena vorikonazola u bolesnika koji već primaju takrolimus, preporučuje se smanjiti dozu takrolimusa na jednu trećinu prijašnje doze i pažljivo kontrolirati razinu
English: Statins (e.g., lovastatin) [CYP3A4 substrates]
Croatian: Statini (npr. lovastatin) [supstrati CYP3A4]
English: Co-administration of voriconazole and sirolimus is contraindicated (see section 4.3).
Croatian: Istodobna primjena vorikonazola i sirolimusa je kontraindicirana (vidjeti dio 4.3).
English: Use of voriconazole in prophylaxis for greater than 180 days (6 months) requires careful assessment of the benefit-risk balance (see sections 4.4 and 5.1).
Croatian: Upotreba vorikonazola u profilaksi duže od 180 dana (6 mjeseci) zahtijeva temeljitu procjenu omjera koristi i rizika (vidjeti dijelove 4.4 i 5.1.)
English: Co-administration with rifampicin, carbamazepine and phenobarbital since these medicinal products are likely to decrease plasma voriconazole concentrations significantly (see section 4.5).
Croatian: Istodobna primjena s rifampicinom, karbamazepinom i fenobarbitalom, jer će navedeni lijekovi vjerojatno dovesti do značajnog smanjenja koncentracije vorikonazola u plazmi (vidjeti dio 4.5.).
English: Total parenteral nutrition (TPN) need not be discontinued when prescribed with Voriconazole Hikma, but does need to be infused through a separate line.
Croatian: Potpuna parenteralna prehrana: Infuzija pripravka potpune parenteralne prehrane (TPN - total parenteral nutrition) ne mora se prekidati ako se istodobno primjenjuje Vorikonazol Hikma, ali je treba davati u zasebnoj infuzijskoj liniji.
English: Efavirenz Cmax ↑ 38% Efavirenz AUCτ ↑ 44% Voriconazole Cmax ↓ 61% Voriconazole AUCτ ↓ 77%
Croatian: Efavirenz Cmax ↑38% Efavirenz AUCτ ↑ 44% Vorikonazol Cmax ↓61% Vorikonazol AUCτ ↓ 77%
English: Long term exposure to voriconazole greater than 180 days (6 months) requires careful assessment of the benefit-risk balance (see sections 4.4 and 5.1).
Croatian: Dugotrajno izlaganje vorikonazolu, duže od 180 dana (6 mjeseci) zahtjeva temeljitu procjenu omjera koristi i rizika (vidjeti dijelove 4.4 i 5.1).
English: When voriconazole is discontinued, ciclosporin levels must be carefully monitored and the dose increased as necessary.
Croatian: Nakon prekida primjene vorikonazola moraju se pažljivo pratiti razine ciklosporina i po potrebi povećati doza.
English: There is no known antidote to voriconazole.
Croatian: Antidot za vorikonazol nije poznat.
English: • Methadone (used to treat heroin addiction)
Croatian: • metadon (koristi se za liječenje ovisnosti o heroinu)
English: Gastrointestin al disorders diarrhoea, vomiting, abdominal pain, nausea cheilitis, dyspepsia, constipation, gingivitis peritonitis, pancreatitis, swollen tongue, duodenitis, gastroenteritis, glossitis
Croatian: Poremećaji probavnog sustava proljev, povraćanje, bol u abdomenu, mučnina heilitis, dispepsija, konstipacija, gingivitis peritonitis, pankreatitis, otečeni jezik, duodenitis, gastroenteritis, glositis
English: Each vial of Voriconazole Hikma contains 217.6 mg of sodium per vial.
Croatian: Jedna bočica Vorikonazola Hikma sadrži 217,6 mg natrija.
English: During infusion of the intravenous formulation of voriconazole in healthy subjects, anaphylactoid-type reactions, including flushing, fever, sweating, tachycardia, chest tightness, dyspnoea, faintness, nausea, pruritus and rash have occurred.
Croatian: Tijekom infuzije intravenskog oblika vorikonazola u zdravih ispitanika su nastupile anafilaktoidne reakcije, uključujući crvenilo praćeno osjećajem užarenosti, vrućicu, znojenje, tahikardiju, stezanje u prsima, zaduhu, nesvjesticu, mučninu, svrbež i osip.
English: • Terfenadine (used for allergy)
Croatian: • terfenadin (koristi se za liječenje alergija)
English: Ritonavir Cmax ↓ 25% Ritonavir AUCτ ↓13% Voriconazole Cmax ↓ 24% Voriconazole AUCτ ↓ 39%
Croatian: Ritonavir Cmax ↓25% Ritonavir AUCτ ↓13% Vorikonazol Cmax ↓24% Vorikonazol AUCτ ↓ 39%
English: No dose adjustment of voriconazole is recommended.
Croatian: Ne preporučuje se prilagodba doze vorikonazola.
English: Frequent monitoring for opiate-associated adverse reactions may be necessary.
Croatian: Možda će biti potrebne česte kontrole zbog mogućih nuspojava povezanih s opijatima.
English: • Health Care Professional (HCP) Checklist for Phototoxicity, SCC and Hepatic toxicity: - Reminds HCPs of the risks of phototoxicity, skin SCC and hepatotoxicity reported with voriconazole use.
Croatian: • Kontrolni spisak za zdravstvenog radnika za fototoksičnost, SCC te za toksičnosti za jetru: - Podsjeća zdravstvene radnike na rizik od fototoksičnosti, SCC kože te o toksičnosti za jetru povezane uz primjenom vorikonazola.
English: Tell your docotor if you experience this.
Croatian: Obavijestite svog liječnika ako imate te nuspojave.
English: Electrolyte disturbances such as hypokalemia, hypomagnesemia and hypocalcemia should be corrected prior to initiation of voriconazole therapy (see sections 4.2 and 4.4).
Croatian: Poremećaje elektrolita poput hipokalemije, hipomagnezemije i hipokalcemije treba korigirati prije započinjanja liječenja vorikonazolom (vidjeti dijelove 4.2 i 4.4).
English: Carbamazepine and long-acting barbiturates (e.g., phenobarbital, mephobarbital) [potent CYP450 inducers]
Croatian: Karbamazepin i barbiturati dugog djelovanja (npr. fenobarbital, mefobarbital)
English: When Voriconazole Hikma treatment is stopped by your doctor you should not experience any effects.
Croatian: Kada liječnik odredi prekid liječenja lijekom Vorikonazol Hikma, ne biste trebali imati nikakvih nuspojava.
English: If patient response to treatment is inadequate, the maintenance dose may be increased to 300 mg twice daily for oral administration.
Croatian: Ako bolesnik ne postiže zadovoljavajući odgovor na liječenje, peroralna doza održavanja može se povećati na 300 mg dvaput na dan.
English: Monitoring for adverse reactions related to oral contraceptives, in addition to those for voriconazole, is recommended.
Croatian: Preporučuje se nadzor zbog nuspojava povezanih s oralnim kontraceptivima, koje mogu nastupiti uz one povezane s primjenom vorikonazola.
English: Phenytoin [CYP2C9 substrate and potent CYP450 inducer] 300 mg QD
Croatian: Fenitoin [supstrat CYP2C9 i snažan induktor CYP450] 300 mg QD
English: • Low numbers of some types, including severe, of red (sometimes immune-related) and/or white blood cells (sometimes with fever), low numbers of cells called platelets that help blood to clot
Croatian: Česte: mogu se javiti u do 1 na 10 osoba - upala sinusa, upala desni, zimica, slabost - smanjen (ukjučujući i značajno smanjen) broj nekih vrsta crvenih (katkad povezano s imunitetom) i/ili bijelih krvnih stanica (katkad popraćeno temperaturom), niski broj stanica koje se nazivaju trombociti i koje pomažu u zgrušavanju krvi
English: Primary Prophylaxis of Invasive Fungal Infections - Efficacy in HSCT recipients without prior proven or probable IFI
Croatian: Sekundarna profilaksa invazivnih gljivičnih infekcija - djelotvornost u primatelja HSCT s prethodnom dokazanom ili vjerojatnom invazivnom gljivičnom infekcijom
English: Co-administration of voriconazole with everolimus is not recommended because voriconazole is expected to significantly increase everolimus concentrations (see section 4.4).
Croatian: Istodobna primjena vorikonazola i everolimusa se ne preporučuje jer se očekuje da bi vorikonazol značajno povisio koncentracije everolimusa (vidjeti dio 4.4).
English: Use of standard doses of voriconazole with efavirenz doses of 400 mg QD or higher is contraindicated (see section 4.3).
Croatian: Primjena standardnih doza vorikonazola s dozama efavirenza od 400 mg QD ili više je kontraindicirana (vidjeti dio
English: Rare (may affect up to 1 in 1000 people)
Croatian: Rijetke: mogu se javiti u do 1 na 1000 osoba
English: EUCAST Breakpoints
Croatian: EUCAST granične vrijednosti
English: Patients with renal failure were excluded from this study.
Croatian: Bolesnici sa zatajenjem bubrega nisu bili uključeni u ispitivanje.
English: Compared to voriconazole 200 mg BID,
Croatian: U usporedbi s dozom vorikonazola od 200 mg BID:,
English: Digoxin Cmax ↔ Digoxin AUCτ ↔
Croatian: Digoksin Cmax ↔ Digoksin AUCτ ↔
English: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Croatian: 6.6 Posebne mjere za zbrinjavanje i druga rukovanja lijekom Neiskorišteni lijek ili otpadni materijal valja zbrinuti sukladno lokalnim propisima.
English: 3 In clinical studies, response to voriconazole in C. krusei infections was similar to C. albicans, C.
Croatian: 3 U kliničkim ispitivanjima je odgovor na vorikonazol u infekcijama čiji je uzročnik bila C. krusei bio podjednak kao u infekcijama uzročnika C. albicans, C. parapsilosis i C. tropicalis.
English: Concomitant use of voriconazole and rifabutin should be avoided unless the benefit outweighs the risk (see section 4.5).
Croatian: Treba izbjegavati istodobnu primjenu vorikonazola i rifabutina, osim u slučajevima kada korist nadilazi rizik (vidjeti dio 4.5).
English: An 8 mg/kg intravenous dose will provide voriconazole exposure approximately 2-fold higher than a 9 mg/kg oral dose.
Croatian: Primjenom intravenske doze od 8 mg/kg omogućuje se približno dvostruko veća izloženost vorikonazolu u odnosu na peroralnu dozu od 9 mg/kg.
English: • Ritonavir (used for treating HIV) in doses of 100 mg twice daily
Croatian: • ritonavir (koristi se za liječenje HIV-a) u dozi od 100 mg dva puta na dan.
English: Vascular disorders hypotension, phlebitis thrombophlebitis, lymphangitis
Croatian: Krvožilni poremećaji hipotenzija, flebitis tromboflebitis, limfangitis
English: In vivo studies indicated that CYP2C19 is significantly involved in the metabolism of voriconazole.
Croatian: Ispitivanja in vivo ukazuju na značajnu ulogu enzima CYP2C19 u metabolizmu vorikonazola.
English: 9 mg/kg every 12 hours
Croatian: 9 mg/kg svakih 12 sati
English: Hepatotoxicity occurred at plasma exposures similar to those obtained at therapeutic doses in humans, in common with other antifungal agents.
Croatian: Kao i kod drugih antimikotika, hepatotoksičnost je zabilježena pri razinama izloženosti u plazmi koje su podjednake onima koje se postižu primjenom terapijskih doza u ljudi.
English: Ergot alkaloids (e.g., ergotamine and dihydroergotamine) [CYP3A4 substrates]
Croatian: Ergot alkaloidi (npr. ergotamin i dihidroergotamin) [supstrati CYP3A4]
English: Efavirenz may be co-administered with voriconazole if the maintenance dose of voriconazole is increased to 400 mg every 12 hours and the efavirenz dose is reduced by 50%, i.e. to 300 mg once daily.
Croatian: Efavirenz se smije istodobno primijeniti s vorikonazolom ako se doza održavanja vorikonazola poveća na 400 mg svakih 12 sati, a doza efavirenza smanji za 50%, tj. na 300 mg jedanput na dan.
English: When multiple doses of voriconazole are administered with high fat meals, Cmax and AUCτ are reduced by 34 % and 24 %, respectively.
Croatian: Nakon višekratne primjene vorikonazola s punomasnim obrokom Cmax se smanjuje za 34%, a AUCτ za 24%.
English: Co-administration with St John's Wort (see section 4.5).
Croatian: Istodobna primjena s gospinom travom (vidjeti dio 4.5).
English: Monitoring for voriconazole associated adverse reactions is recommended if voriconazole is used sequentially after fluconazole (see section 4.5).
Croatian: Preporučuje se nadzor kako bi se uočile nuspojave povezane s vorikonazolom ako se vorikonazol primjenjuje nakon liječenja flukonazolom (vidjeti dio 4.5).
English: * Primary endpoint of study ** Using a margin of 5%, non inferiority is demonstrated ***Difference in proportions, 95% CI obtained after adjustment for randomization
Croatian: * Primarni ishod ispitivanja ** Uz primjenu granice od 5%, dokazana je neinferiornost ***Razlika u udjelima, 95%-tni CI dobiven nakon prilagodbe za randomizaciju
English: In patients with moderate to severe renal dysfunction (creatinine clearance < 50 ml/min), accumulation of the intravenous vehicle, SBECD, occurs.
Croatian: U bolesnika s umjerenom do teškom disfunkcijom bubrega (klirens kreatinina < 50 ml/min), dolazi do kumulacije intravenskog vehikuluma, natrijevog sulfobutileter beta ciklodekstrina (SBECD).
English: * Primary endpoint of study ** Using a margin of 5%, non inferiority is demonstrated *** Difference in proportions, 95% CI obtained after adjustment for randomization
Croatian: * Primarni ishod ispitivanja ** Uz primjenu tolerancije od 5%, dokazana je neinferiornost *** Razlika u udjelima, 95%-tni CI dobiven nakon prilagodbe za randomizaciju
English: • Treatment of serious fungal infections caused by Scedosporium spp.
Croatian: • liječenje teških gljivičnih infekcija uzrokovanih vrstama iz rodova Scedosporium i Fusarium.
English: This medicinal product must not be mixed with other medicinal products except those mentioned in section
Croatian: Lijek se ne smije miješati s drugim lijekovima osim onih navedenih u dijelu 6.6 6.3 Rok valjanosti
English: When voriconazole is discontinued, tacrolimus levels must be carefully monitored and the dose increased as necessary.
Croatian: Nakon prekida primjene vorikonazola moraju se pažljivo pratiti razine takrolimusa i po potrebi povisiti doza.
English: Concomitant use of voriconazole and rifabutin should be avoided unless the benefit outweighs the risk.
Croatian: Istodobnu primjenu vorikonazola i rifabutina treba izbjegavati, osim kad korist nadilazi rizik liječenja.
English: • Visual impairment (change in vision including blurred vision, visual color alterations, abnormal intolerance to visual perception of light, colour blindness, eye disorder, halo vision, night blindness,
Croatian: - oštećenje vida (promjene vida koje uključuju zamagljeni vid, izmjene doživljaja boja, neuobičajenu netoleranciju na vizualnu percepciju svjetlosti, sljepoću za boje, poremećaje oka, halo vid, noćnu sljepoću, ljuljajuću sliku, iskrenje pred očima, vizualnu auru, smanjenu oštrinu vida, vizualnu svjetlinu, gubitak dijela uobičajenog vidnog polja, točke pred očima)
English: St John's Wort [CYP450 inducer; P-gp inducer] 300 mg TID (co-administered with voriconazole 400 mg single dose)
Croatian: Gospina trava [induktor CYP450; induktor P-glikoproteina] 300 mg TID (primijenjeno istodobno s jednom dozom vorikonazola od 400 mg)
English: 4 mg/kg twice a day
Croatian: 4 mg/kg dvaput na dan
English: In clinical trials, visual impairments (including blurred vision, photophobia, chloropsia, chromatopsia, colour blindness, cyanopsia, eye disorder, halo vision, night blindness, oscillopsia, photopsia, scintillating scotoma, visual acuity reduced, visual brightness, visual field defect, vitreous floaters, and xanthopsia) with voriconazole were very common.
Croatian: Oštećenja vida s vorikonazolom bila su vrlo česta u kliničkim ispitivanjima (uključujući zamagljeni vid, fotofobiju, kloropsiju, kromatopsiju, sljepoću za boje, cijanopsiju, poremećaj oka, halo vid, noćnu sljepoću, oscilopsiju, fotopsiju, svjetlucajuću skotomu, smanjenje oštrine vida, svjetlinu vida, ispade vidnog polja, skotome i ksanatopsiju).