FrancophonIA/ELRC3.0 huggingface dataset:
English: • Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction) including patients undergoing a stent placement following percutaneous coronary intervention
Slovenian: • akutnem koronarnem sindromu brez elevacije ST spojnice (nestabilna angina ali miokardni infarkt brez Q-zobca), vključno z bolniki, katerim je bila vstavljena opornica po perkutani koronarni intervenciji,
English: • paclitaxel, medicine to treat cancer,
Slovenian: • paklitaksel, zdravilo za zdravljenje raka,
English: • if you have a medical condition that includes the combination of asthma, nasal discharge (runny nose) and polyps (a type of growth in the nose).
Slovenian: • če imate kombinacijo astme, izcedka iz nosu in polipov (polipi so vrsta tkivne rašče v nosu),
English: th month of pregnancy), acetylsalicylic acid should not be given unless clearly necessary.
Slovenian: Do 24. tedna amenoreje (5. meseca nosečnosti) se acetilsalicilne kisline ne sme uporabljati, če ni nujno potrebno.
English: There is insufficient clinical experience regarding the use of doses above 100 mg/day up to 500 mg/day.
Slovenian: Z uporabo odmerkov nad 100 mg/dan in do 500 mg/dan ni dovolj kliničnih izkušenj.
English: • the varicella vaccine, a medicine used to prevent chickenpox or shingles, within 6 weeks of taking Clopidogrel/Acetylsalicylic acid Mylan, or if you have active chickenpox or shingles infection (see section 2 ‘Children and adolescents'),
Slovenian: • cepivo proti noricam, ki preprečuje nastanek noric ali pasastega izpuščaja, 6 tednov po zaužitju zdravila Klopidogrel/acetilsalicilna kislina Mylan, ali med okužbo z noricami ali s pasastim izpuščajem (glejte poglavje 2 »Otroci in mladostniki«),
English: • moclobemide, medicine to treat depression,
Slovenian: • moklobemid, zdravilo za zdravljenje depresije,
English: Clopidogrel/Acetylsalicylic acid Mylan should be used with caution in patients with a history of peptic ulcer or gastroduodenal haemorrhage or minor upper GI symptoms as this may be due to gastric ulceration which may lead to gastric bleeding.
Slovenian: Zdravilo Klopidogrel/acetilsalicilna kislina Mylan morate previdno uporabljati pri bolnikih z anamnezo peptične razjede, gastroduodenalne krvavitve ali manj izrazitih gastrointestinalnih simptomov zgornjega trakta, saj so ti simptomi lahko posledica želodčne razjede, ki lahko povzroči krvavitev v želodcu.
English: Clopidogrel/Acetylsalicylic acid Mylan is a fixed-dose combination medicinal product for continuation of therapy in:
Slovenian: Zdravilo Klopidogrel/acetilsalicilna kislina Mylan je kombinirano zdravilo s stalnim odmerkom za nadaljevalno zdravljenje pri:
English: There are no fertility data with clopidogrel/acetylsalicylic acid.
Slovenian: Podatkov o plodnosti za klopidogrel/acetilsalicilno kislino ni.
English: Due to the presence of ASA, Clopidogrel/Acetylsalicylic acid Mylan is contraindicated during the third trimester of pregnancy.
Slovenian: Zaradi vsebnosti ASA je zdravilo Klopidogrel/acetilsalicilna kislina Mylan kontraindicirano v tretjem trimesečju nosečnosti.
English: Jaundice (yellowing of skin and/or eyes); burning in stomach and/or oesophagus (gullet); severe abdominal pain with or without back pain; fever, breathing difficulties sometimes associated with cough; generalised allergic reactions (for example, overall sensation of heat with sudden general discomfort until fainting); swelling in the mouth; blisters of the skin; skin allergy; sore mouth (stomatitis); decrease in blood pressure; confusion; hallucinations; joint pain; muscular pain; changes in taste or loss of taste of foods, inflammation of small vessels.
Slovenian: Zlatenica (porumenelost kože in/ali oči), pekoč občutek v želodcu in/ali požiralniku (grlu), huda bolečina v trebuhu z ali brez bolečine v hrbtu, zvišana telesna temperatura, težave pri dihanju, ki so včasih povezane s kašljem, splošne alergijske reakcije (na primer, splošni občutek toplote z nenadnim nelagodjem do nezavesti), oteklina v ustih, mehurji na koži, kožna alergija, vnetje v ustih (stomatitis), znižanje krvnega tlaka, zmedenost, halucinacije, bolečine v sklepih, bolečine v mišicah, motnje okusa ali izguba okusa, vnetje malih žil.
English: The concomitant administration of salicylates and valproic acid may result in decreased valproic acid protein binding and inhibition of valproic acid metabolism resulting in increased serum levels of total and free valproic acid.
Slovenian: Sočasna uporaba salicilatov in valprojske kisline lahko vodi v zmanjšano vezavo valprojske kisline na proteine in v inhibicijo presnove valprojske kisline, kar se kaže v porastu serumskih koncentracij skupne in proste valprojske kisline.
English: Due to the risk of bleeding and haematological adverse reactions, blood cell count determination and/or other appropriate testing should be promptly considered whenever clinical symptoms suggestive of bleeding arise during the course of treatment (see section 4.8).
Slovenian: Zaradi tveganja za krvavitve in hematološke neželene učinke je potrebno v primeru kliničnih simptomov, ki nakazujejo krvavitev med zdravljenjem, takoj pregledati krvno sliko in/ali narediti druge ustrezne preiskave (glejte poglavje 4.8).
English: Intracranial bleeding (some cases were reported with fatal outcome, especially in elderly), headache, paraesthesia, dizziness
Slovenian: Bolezni živčevja intrakranialna krvavitev (opisani so primeri s smrtnim izidom, zlasti pri starejših), glavobol, parestezije, omotica motnje okusa, agevzija
English: This effect lasts for the life of the platelet.
Slovenian: Učinek traja celotno življenjsko dobo trombocitov.
English: • methotrexate, a medicine used to treat severe joint disease (rheumatoid arthritis) or skin disease (psoriasis),
Slovenian: • metotreksat, zdravilo za zdravljenje hude bolezni sklepov (revmatoidnega artritisa) ali bolezni kože (luskavice),
English: As a dual antiplatelet agent, Clopidogrel/Acetylsalicylic acid Mylan should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions and in patients receiving treatment with other NSAIDs including Cox-2 inhibitors, heparin, glycoprotein IIb/IIIa inhibitors, selective serotonin reuptake inhibitors (SSRIs), thrombolytics, or other medicinal products associated with bleeding risk such as pentoxifylline (see section 4.5).
Slovenian: Zdravilo Klopidogrel/acetilsalicilna kislina Mylan kot dvojno antiagregacijsko sredstvo je treba previdno uporabljati pri bolnikih s povečanim tveganjem krvavitev zaradi poškodbe, kirurškega posega ali drugih patoloških stanj in pri bolnikih, ki so na zdravljenju z drugimi nesteroidnimi protivnetnimi zdravili vključno z zaviralci COX2, heparinom, zaviralci glikoproteina IIb/IIIa, s selektivnimi zaviralci privzema serotonina (SSRI), trombolitiki ali z drugimi zdravili, ki so povezana s tveganjem za krvavitve, kot je pentoksifilin (glejte poglavje 4.5).
English: Overdose with ASA/clopidogrel fixed dose combination may be associated with increased bleeding and subsequent bleeding complications due to the pharmacological activity of clopidogrel and ASA.
Slovenian: Preveliko odmerjanje fiksne kombinacije acetilsalicilne kisline/klopidogrela lahko spremljajo večja nagnjenost h krvavitvam in posledični krvavitveni zapleti; to je posledica farmakološkega delovanja klopidogrela in acetilsalicilne kisline.
English: Elimination Following an oral dose of
Slovenian: Izločanje Po peroralnem odmerku
English: Do not swallow the desiccant.
Slovenian: Ne pogoltnite sušilnega sredstva.
English: • ST segment elevation acute myocardial infarction in medically treated patients eligible for thrombolytic therapy
Slovenian: • akutnem miokardnem infarktu z elevacijo ST spojnice pri bolnikih, ki se zdravijo z zdravili in so primerni za trombolitično zdravljenje.
English: Patients should be counselled about the risks of gastrointestinal injury and bleeding while taking clopidogrel plus ASA with alcohol, especially if alcohol consumption is chronic or heavy (see section 4.4).
Slovenian: Bolnike je treba opozoriti o povečani nevarnosti gastrointestinalnih poškodb in krvavitev pri sočasnem zaužitju klopidogrela in ASA z alkoholom, še posebej, če gre za veliko ali kronično rabo alkohola (glejte poglavje 4.4.
English: Renal failure*, acute renal impairment (especially in patients with existing renal impairment, heart decompensation, nephritic syndrome, or concomitant treatment with diuretics) *, glomerulonephritis, blood creatinine increased
Slovenian: Bolezni sečil hematurija odpoved ledvic akutna okvara ledvic (zlasti pri bolnikih z obstoječo okvaro ledvic, srčnim popuščanjem, nefritičnim sindromom ali sočasnim zdravljenjem z diuretiki) glomerulonefritis, zvišanje kreatinina v krvi
English: As a precaution, concomitant use of strong or moderate CYP2C19 inhibitors should be discouraged (see section 4.5 for a list of CYP2C19 inhibitors, see also section 5.2).
Slovenian: Iz previdnosti naj sočasno ne bi uporabljali močnih ali srednje močnih zaviralcev CYP2C19 (za seznam zaviralcev CYP2C19 glejte poglavje 4.5; glejte tudi poglavje 5.2).
English: Clopidogrel
Slovenian: Klopidogrel
English: Clopidogrel/Acetylsalicylic acid Mylan contains clopidogrel and acetylsalicylic acid (ASA) and belongs to a group of medicines called antiplatelet medicinal products.
Slovenian: Zdravilo Klopidogrel/acetilsalicilna kislina Mylan vsebuje klopidogrel in acetilsalicilno kislino (ASA) in spada v skupino zdravil, ki se imenujejo zaviralci agregacije trombocitov.
English: Recent transient ischaemic attack or stroke
Slovenian: Nedavne tranzitorne ishemične atake (TIA)
English: Metamizole may reduce the effect of ASA on platelet aggregation when taken concomitantly.
Slovenian: Metamizol lahko zmanjša vpliv acetilsalicilne kisline na agregacijo trombocitov, če sta zdravili uporabljeni sočasno.
English: 2D barcode carrying the unique identifier included
Slovenian: Vsebuje dvodimenzionalno črtno kodo z edinstveno oznako
English: Colitis (including ulcerative or lymphocytic colitis), stomatitis, acute pancreatitis in the context of a hypersensitivity reaction due to acetylsalicylic acid*
Slovenian: Kolitis (vključno z ulceroznim ali limfocitnim kolitisom), stomatitis, akutni pankreatitis v okviru preobčutljivostne reakcije zaradi acetilsalicilne kisline
English: Do not take Clopidogrel/Acetylsalicylic acid Mylan during third trimester of pregnancy.
Slovenian: Zdravila Klopidogrel/acetilsalicilna kislina Mylan ne smete jemati v tretjem trimesečju nosečnosti.
English: Clopidogrel/Acetylsalicylic acid Mylan fixed-dose combination is used following initiation of therapy with clopidogrel and ASA given separately and replaces the individual clopidogrel and ASA products.
Slovenian: Kombinirano zdravilo Klopidogrel/acetilsalicilna kislina Mylan se uporablja po začetni ločeni terapiji s klopidogrelom in ASA, namesto posameznega zdravila s klopidogrelom ali ASA:
English: Valproic acid
Slovenian: Valprojska kislina
English: What Clopidogrel/Acetylsalicylic acid Mylan is and what it is used for What you need to know before you take Clopidogrel/Acetylsalicylic acid Mylan How to take Clopidogrel/Acetylsalicylic acid Mylan Possible side effects
Slovenian: Kaj je zdravilo Klopidogrel/acetilsalicilna kislina Mylan in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Klopidogrel/acetilsalicilna kislina Mylan
English: Subsequently a respiratory acidosis occurs as a result of a suppressive effect on the respiratory centre.
Slovenian: Potem se zaradi supresivnega učinka na dihalni center pojavi respiratorna acidoza.
English: If you have any further questions, ask your doctor, or pharmacist.
Slovenian: - Če imate dodatna vprašanja, se posvetujte z zdravnikom ali farmacevtom.
English: The recommended dose is one tablet of Clopidogrel/Acetylsalicylic acid Mylan per day to be taken orally with a glass of water, with or without food.
Slovenian: Priporočeni odmerek je ena tableta zdravila Klopidogrel/acetilsalicilna kislina Mylan na dan. Tableto vzemite s kozarcem vode.
English: • This medicinal product must be administered under close medical supervision in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to risk of haemolysis (see section 4.8).
Slovenian: • Pri bolnikih s pomanjkanjem glukoza-6-fosfat-dehidrogenaze (G6PD) je treba to zdravilo uporabljati pod natančnim zdravniškim nadzorom, ker pri njih obstaja tveganje za hemolizo (glejte poglavje 4.8).
English: Clopidogrel/Acetylsalicylic acid Mylan contains lactose.
Slovenian: Zdravilo Klopidogrel/acetilsalicilna kislina Mylan vsebuje laktozo.
English: In CURE there was no excess in major bleeds with clopidogrel plus ASA within 7 days after coronary bypass graft surgery in patients who stopped therapy more than five days prior to surgery.
Slovenian: V CURE pri bolnikih, ki so imeli narejeno koronarno premostitev in so pred tem uporabljali klopidogrel in ASA, v 7 dneh po operaciji niso ugotovili čezmernega števila hujših krvavitev, če so to zdravljenje prekinili pet dni pred operacijo.
English: The most common side effect which has been seen with Clopidogrel/Acetylsalicylic acid Mylan is bleeding.
Slovenian: Najpogostejši neželeni učinek med zdravljenjem z zdravilom Klopidogrel/acetilsalicilna kislina Mylan so krvavitve.
English: The 2x2 factorial design COMMIT trial included 45,852 patients presenting within 24 hours of the onset of the symptoms of suspected MI with supporting ECG abnormalities (i.e. ST elevation, ST
Slovenian: V raziskavo COMMIT z 2×2 faktorsko raziskovalno zasnovo je bilo vključenih 45.852 bolnikov v 24 urah po nastopu simptomov, ki bi lahko kazali na miokardni infarkt, z neustreznimi vrednostmi EKG, ki so to potrjevale (elevacija ST spojnice, depresija ST spojnice ali levokračni blok).
English: Consider the use of a parenteral antiplatelet agent in acute coronary syndrome patients requiring co-administration of morphine or other opioid agonists.
Slovenian: Pri bolnikih z akutnim koronarnim sindromom, ki potrebujejo sočasno uporabo morfina ali drugih opioidnih agonistov, razmislite o uporabi parenteralnega antiagregacijskega zdravila.
English: Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly.
Slovenian: Eksperimentalni podatki kažejo, da lahko ibuprofen med sočasno uporabo majhnih odmerkov acetilsalicilne kisline zavre njen učinek na agregacijo trombocitov.
English: What Clopidogrel/Acetylsalicylic acid Mylan is and what it is used for
Slovenian: Kaj je zdravilo Klopidogrel/acetilsalicilna kislina Mylan in za kaj ga uporabljamo
English: Aluminium blisters with desiccant layer containing 28 or 30 film-coated tablets.
Slovenian: Aluminijasti pretisni omoti s sušilno plastjo, ki vsebujejo 28 ali 30 filmsko obloženih tablet.
English: Breast-feeding should be discontinued during treatment with Clopidogrel/Acetylsalicylic acid Mylan.
Slovenian: Dojenje je med zdravljenjem z zdravilom Klopidogrel/acetilsalicilna kislina Mylan potrebno prekiniti.
English: Patients should be told about the signs and symptoms of GI undesirable effects and what steps to take if they occur.
Slovenian: Bolnike je treba seznaniti z znaki in simptomi neželenih gastrointestinalnih učinkov in jim povedati, kako naj ukrepajo, če bi se ti pojavili (glejte poglavje 4.8.
English: New cardiovascular events (primary endpoint) were prevented, with relative risk reductions of 22% (CI: 8.6, 33.4), 32% (CI: 12.8, 46.4), 4% (CI: -26.9, 26.7), 6% (CI: -33.5, 34.3) and 14% (CI: -31.6, 44.2), during the 0-1, 1-3, 3-6, 6-9 and 9-12-month study intervals, respectively.
Slovenian: 8,6; 33,4), 32 % (IZ: 12,8; 46,4), 4 % (IZ: −26,9; 26,7), 6 % (IZ: −33,5; 34,3), 14 % (IZ:
English: • nicorandil, medicine to treat cardiac chest pain.
Slovenian: • nikorandil, zdravilo za zdravljenje bolečine v prsih srčnega izvora,
English: The following symptoms are associated with moderate intoxication: dizziness, headache, tinnitus, confusion and gastrointestinal symptoms (nausea, vomiting and gastric pain).
Slovenian: Preveliko odmerjanje se kaže z naslednjimi simptomi: omotico, glavobolom, tinitusom, zmedenostjo in prebavnimi simptomi (navzea, bruhanje in želodčna bolečina).
English: GI undesirable effects including stomach pain, heartburn, nausea, vomiting, and GI bleeding may occur.
Slovenian: Pojavijo se lahko gastrointestinalni (GI) neželeni učinki, vključno z bolečino v želodcu, zgago, navzeo, bruhanjem in krvavitvijo v prebavila.
English: Clopidogrel/Acetylsalicylic acid Mylan should be used with caution in patients who receive concomitant glycoprotein IIb/IIIa inhibitors (see section 4.4).
Slovenian: Zdravilo Klopidogrel/acetilsalicilna kislina Mylan morate uporabljati previdno pri bolnikih, ki prejemajo sočasno zaviralce glikoproteina IIb/IIIa (glejte poglavje 4.4).
English: Moreover, the safety profile of clopidogrel in this subgroup of patients did not raise any particular concern.
Slovenian: Pri tej podskupini bolnikov tudi niso ugotovili nobenih posebnih težav z varnostjo klopidogrela.
English: The Cmax of the active metabolite is twice as high following a single 300 mg clopidogrel loading dose as it is after four days of 75 -mg maintenance dose.
Slovenian: Cmax aktivnega presnovka je po enem 300-mg polnilnem odmerku klopidogrela dvakrat večja kot po štirih dneh uporabe vzdrževalnega odmerka 75 mg. Cmax je dosežena približno 30 do 60 minut po uporabi zdravila.
English: Clopidogrel/Acetylsalicylic acid Mylan has no or negligible influence on the ability to drive and use machines.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja strojev Zdravilo Klopidogrel/acetilsalicilna kislina Mylan nima ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: Patients were randomised to clopidogrel (300 mg loading dose followed by 75 mg/day, N=6,259) plus ASA (75-325 mg once daily) or ASA alone (N=6,303), (75-325 mg once daily) and other standard therapies.
Slovenian: Bolniki so bili naključno razporejeni v skupino, ki je prejemala klopidogrel (začetni odmerek 300 mg, nato 75 mg/dan, N = 6.259) in ASA (75 - 325 mg enkrat dnevno) ali samo ASA (N = 6.303), (75 - 325 mg enkrat dnevno) in drugimi standardnimi terapijami.
English: • repaglinide, medicine to treat diabetes,
Slovenian: • repaglinid, zdravilo za zdravljenje sladkorne bolezni,
English: • if you suffer from severe liver disease.
Slovenian: • če imate hudo bolezen ledvic,
English: Therapeutic experience is limited in patients with moderate hepatic disease who may have bleeding diatheses (see section 4.4).
Slovenian: Terapevtskih izkušenj pri bolnikih z zmerno boleznijo jeter, ki imajo lahko hemoragično diatezo, je malo (glejte poglavje 4.4).
English: Common side effects (may affect up to 1 in 10 people): Diarrhoea, abdominal pain, indigestion or heartburn.
Slovenian: Pogosti neželeni učinki (pojavijo se lahko pri največ 1 od 10 bolnikov): Driska, bolečine v trebuhu, težave z želodcem ali zgaga.
English: Therapeutic experience is limited in patients with mild to moderate renal impairment (see section 4.4).
Slovenian: Terapevtskih izkušenj pri bolnikih z blago do zmerno okvaro ledvic je malo (glejte poglavje 4.4).
English: The number of patients experiencing the co-primary endpoint (CV death, MI, stroke or refractory ischaemia) was 1,035 (16.5%) in the clopidogrel plus ASA group and 1,187 (18.8%) in the ASA group, a 14% relative risk reduction (95% CI of 6%-21%, p=0.0005) for the clopidogrel plus ASA group.
Slovenian: Število bolnikov s primarnim opazovanim dogodkom (SŽ smrt, MI, kap ali neodzivna ishemija) je bilo 1.035 (16,5 %) v skupini zdravljeni s klopidogrelom in ASA in 1.187 (18,8 %) v skupini z ASA, to je 14 % zmanjšanje relativnega tveganja (95 % IZ od 6 %
English: Side effects with frequency not known (frequency cannot be estimated from the available data): Ulcer perforation, ringing in the ears, hearing loss, sudden life-threatening allergic or hypersensitivity reactions with chest or abdominal pain, kidney disease, low blood sugar, gout (a condition of painful, swollen joints caused by uric acid crystals) and worsening of food allergies, a particular form of anaemia (low number of red blood cells) (see section 2 ‘Warnings and precautions'), swelling.
Slovenian: Predrtje razjede, zvonjenje v ušesih, poslabšanje sluha, nenadne smrtno nevarne alergijske ali preobčutljivostne reakcije z bolečinami v prsih ali trebuhu, bolezen ledvic, nizek krvni sladkor, protin (stanje z bolečimi, oteklimi sklepi, ki ga povzročijo kristali sečne kisline) in poslabšanje alergij na hrano, posebna oblika anemije (nizko število rdečih krvnih celic) (glejte poglavje 2 »Opozorila in previdnostni ukrepi«).
English: Interactions with the following medicinal products with higher (anti-inflammatory) doses of ASA have also been reported: angiotensin converting enzyme (ACE) inhibitors, phenytoin, beta blockers, diuretics, and oral hypoglycemic agents.
Slovenian: Med uporabo večjih (protivnetnih) odmerkov ASA so opisane interakcije z naslednjmi zdravili: zaviralci angiotenzin konvertaze (ACE), fenitoin, zaviralci adrenergičnih receptorjev beta, diuretiki in peroralni antidiabetiki.
English: Serious haemorrhage, haemorrhage of operative wound, vasculitis (including Henoch-Schönlein purpura*), hypotension
Slovenian: Žilne bolezni hematom resne krvavitve, krvavitev operacijske rane, vaskulitis (vključno s HenochSchönleinovo purpuro
English: Patients received clopidogrel (300 mg loading dose, followed by 75 mg/day, n=1,752) plus ASA or ASA alone (n=1,739), (150 to 325 mg as a loading dose, followed by 75 to 162 mg/day), a fibrinolytic agent and, when appropriate, heparin.
Slovenian: Bolniki so dobivali klopidogrel (300 mg udarni odmerek, nato pa 75 mg dnevno, n = 1.752) in ASA ali samo ASA (n = 1.739), (150 mg do 325 mg kot udarni odmerek, nato 75 mg do 162 mg dnevno), fibrinolitičnim sredstvom in po potrebi heparinom.
English: Patients received clopidogrel (75 mg/day, n=22,961) plus ASA (162 mg/day), or ASA alone (162 mg/day) (n=22,891), for 28 days or until hospital discharge.
Slovenian: Bolniki so 28 dni oziroma do odpusta dobivali klopidogrel (75 mg dnevno, n = 22.961) in ASA (162 mg dnevno), ali samo ASA (162 mg dnevno, n = 22.891).
English: Patients were randomized to receive either prasugrel 5 or 10 mg/d (Days 0-14) (n=1306), or prasugrel 5 or 10 mg/d (Days 0-7) then de-escalated to clopidogrel 75 mg/d (Days 8-14) (n=1306), in combination with ASA (<100 mg/day).
Slovenian: Bolnike so randomizirali bodisi na prejemanje prasugrela 5 ali 10 mg/dan (od 0. do 14. dne) (n = 1309) bodisi na prejemanje prasugrela 5 ali 10 mg/dan (od 0. do 7. dne) s poznejšim deeskaliranjem na 75 mg klopidogrela na dan (od 8. do 14. dne) (n = 1309) v kombinaciji z ASA (< 100 mg/dan).
English: Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Slovenian: Če sta bila klopidogrel in omeprazol 80 mg uporabljena istočasno ali v presledku 12 ur, se je izpostavljenost aktivnemu presnovku klopidogrela zmanjšala za 45 % (začetni odmerek) oz.
English: No clinically significant pharmacodynamic interactions were observed when clopidogrel was co-administered with atenolol, nifedipine, or both atenolol and nifedipine.
Slovenian: Pri sočasni uporabi klopidogrela z atenololom, nifedipinom, ali z obema - atenololom in nifedipinomniso opazili nobenih klinično pomembnih farmakodinamičnih interakcij.
English: From the beginning of the sixth month of pregnancy, all prostaglandin synthesis inhibitors may expose: the foetus to: cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension); renal dysfunction, which may progress to renal failure with oligo-hydroamniosis;
Slovenian: • plod: - kardiopulmonalnim toksičnim učinkom (s prezgodnjim zaprtjem arterioznega duktusa in pljučno hipertenzijo), - motenemu delovanju ledvic, ki lahko napreduje v odpoved ledvic in oligohidramnij;