FrancophonIA/ELRC3.0 huggingface dataset:
English: In the absence of compatibility studies, this product should not be mixed with other veterinary medicinal products.
Slovenian: Zaradi odsotnosti študij kompatibilnosti se tega zdravila ne sme mešati z drugimi zdravili za uporabo v veterinarski medicini.
English: It was accepted that this level of resistance could not be directly extrapolated to doxycycline.
Slovenian: Sprejeto je bilo, da se ta raven odpornosti ne more neposredno ekstrapolirati na doksiciklin.
English: Since mostly this is caused by overdosage, it is important to measure the dosage accurately.
Slovenian: Ker gre v večini teh primerov za čezmerni odmerek, je pomembno, da odmerek pravilno izmerite.
English: The use of the product as proposed is not expected to pose a risk for the environment.
Slovenian: Predlagana uporaba zdravila naj ne bi predstavljala tveganja za okolje.
English: Quarterly, 10,48-52 (1988)
Slovenian: The Vet Quarterly, 10, 48-52 (1988)
English: Pigs: 8 days
Slovenian: Prašiči: 8 dni
English: Considering all factors there was insufficient evidence to justify an alteration in the dose rate or regimen.
Slovenian: Ob upoštevanju vseh dejavnikov ni bilo dovolj dokazov, ki bi upravičili spremembo odmerka ali režima odmerjanja.
English: The final conclusion for the benefit: risk balance for the use of the product remains positive.
Slovenian: Končna ocena razmerja med tveganji in koristmi za uporabo tega zdravila ostaja pozitivna.
English: The presence of food in the intestine has no effect on the actual absorption of doxycycline.
Slovenian: Prisotnost hrane v črevesju nima vpliva na dejansko absorpcijo doksiciklina.
English: THE WORDS "FOR ANIMAL TREATMENT ONLY" AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, if applicable
Slovenian: BESEDILO „SAMO ZA ŽIVALI“ IN POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE, če je navedba smiselna
English: OTHER INFORMATION To be completed nationally
Slovenian: DRUGE INFORMACIJE Izpolni se na nacionalni ravni
English: The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours.
Slovenian: Dnevno količino zdravila je treba dodati pitni vodi na tak način, da se vse zdravilo zaužije v 24 urah.
English: It is clear that there are very limited scientific data available to support many of the proposed indications for use of the product, however it could be considered to have “well established use”.
Slovenian: Jasno je, da so razpoložljivi znanstveni podatki v podporo več predlaganim indikacijam za uporabo tega zdravila zelo omejeni, vendar pa lahko velja, da ima zdravilo „dobro uveljavljeno uporabo“.
English: = .... mg product per litre drinking water
Slovenian: = .... mg zdravila na liter pitne vode
English: A summary of field trial data (Van Gool, 198612) provided evidence of efficacy of Ronaxan P.S.
Slovenian: Povzetek podatkov iz terenskega preskušanja (Van Gool, 198612) je ponudil dokaze o učinkovitosti zdravila Ronaxan P.S.
English: To ensure a correct dosage body weight should be determined as accurately as possible.
Slovenian: Za zagotovitev ustreznega odmerjanja morate telesno maso določiti čim bolj natančno.
English: The medicated milk replacer should be used immediately.
Slovenian: Mlečni nadomestek z zdravilom morate uporabiti nemudoma.
English: Do not use after the expiry date stated on the label after exp.
Slovenian: Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na nalepki po exp.
English: In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.
Slovenian: Da zagotovite pravilen odmerek, boste morda morali prilagoditi koncentracijo zdravila v pitni vodi.
English: For animal treatment only - to be supplied only on veterinary prescription.
Slovenian: Samo za živali - le na veterinarski recepta.
English: • Indications;
Slovenian: • indikacijah;
English: As no data have been provided for species of poultry other than chickens, it was agreed that the target species should be restricted to “chickens” across all Member States where the product is authorised or pending authorisation.
Slovenian: Ker razen za piščance niso bili predloženi nobeni podatki za drugo perutnino, je bilo dogovorjeno, da je treba ciljne živalske vrste omejiti na „piščance“ v vseh državah članicah, v katerih je zdravilo odobreno ali čaka na odobritev.
English: The study highlighted the importance of susceptibility testing prior to treatment with doxycycline.
Slovenian: S študijo so poudarili pomen testiranja občutljivosti pred zdravljenjem z doksiciklinom.
English: Overall summary of the scientific evaluation of Doxycycline 50% WSP and associated names (see annex I)
Slovenian: Splošni povzetek znanstvenega vrednotenja zdravila Doxycycline 50% WSP in povezanih imen (glejte Prilogo I)
English: Doxycycline is quickly and almost completely absorbed from the intestine.
Slovenian: Doksiciklin se hitro in skoraj v popolnosti absorbira iz črevesja.
English: The uptake of medicated water is dependant on the clinical conditions of the animals.
Slovenian: Pitje vode z zdravilom je odvisno od kliničnega stanja živali.
English: It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required.
Slovenian: Priporoča se, da pripravite koncentrirano predraztopino, ki vsebuje približno 100 gramov zdravila na liter pitne vode - nato pa to raztopino po potrebi razredčite na terapevtske koncentracije.
English: There have been no discrepancies across the Member States in the following indications:
Slovenian: Pri naslednjih indikacijah med državami članicami ni bilo neskladij:
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Per gram:
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA
English: Due to the divergent national decisions taken by Member States concerning the authorisation of Doxycycline 50 % WSP and associated names, the issue was referred to CVMP under Article 34(1) of Directive 2001/82/EC, in order to resolve divergences amongst the nationally authorised Summary of Product Characteristics (SPC) across the European Union.
Slovenian: Zaradi različnih nacionalnih odločitev držav članic glede odobritve zdravila Doxycycline 50% WSP in povezanih imen je bila zadeva napotena na CVMP v skladu s členom 34(1) Direktive 2001/82/ES, da bi se odpravile razlike med nacionalno odobrenimi povzetki glavnih značilnosti zdravila v Evropski uniji.
English: Therefore the product should be used for the treatment of infections caused by E. coli only after susceptibility testing has been carried out.
Slovenian: Zaradi tega se lahko zdravilo uporablja za zdravljenje okužb, ki jih povzroča bakterija E. coli, samo po izvedbi preskušanja občutljivosti na zdravilo.
English: For a full list of excipients, see section 6.1.
Slovenian: Pomožne snovi: Za celoten seznam pomožnih snovi, glejte poglavje 6.1.
English: There are no proposals to alter the dose regimen for chickens, pigs and calves thus the exposure of the environment to doxycycline will not increase.
Slovenian: Za režim odmerjanja pri piščancih, prašičih in teletih ni predlogov za spremembe, zato se ne bo povečala niti izpostavljenost okolja doksiciklinu.
English: NAME OF THE VETERINARY MEDICINAL PRODUCT To be completed nationally
Slovenian: IME ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI Izpolni se na nacionalni ravni
English: • Target species;
Slovenian: • ciljnih živalskih vrstah;
English: Although the data provided suggested that that this dose might not be optimal and there is recent literature evidence for resistance development in swine respiratory pathogens to tetracyclines, there was no clear evidence upon which to base a revision of the dose/indications.
Slovenian: Čeprav predloženi podatki kažejo, da ta odmerek morda ni optimalen, in v nedavno objavljeni literaturi obstajajo dokazi za razvoj odpornosti na tetracikline pri patogenih iz prašičjih dihal, pa ni bilo nobenih jasnih dokazov, na podlagi katerih bi bilo mogoče zahtevati ponoven pregled odmerka/indikacij.
English: There have been no major discrepancies across the Member States in the following indications:
Slovenian: Pri naslednjih indikacijah med državami članicami ni bilo večjih neskladij:
English: DATE OF REVISION OF THE TEXT To be completed nationally
Slovenian: DATUM REVIZIJE BESEDILA Izpolni se na nacionalni ravni
English: Shelf life after reconstitution in drinking water: 24 hours.
Slovenian: Rok uporabnosti po rekonstituciji v pitni vodi: 24 ur.
English: Alternatively, the concentrated solution can be used in a proportional water medicator.
Slovenian: Namesto tega lahko koncentrirano raztopino uporabite v pripomočku za dajanje proporcionalnega odmerka v vodo.
English: Medicated drinking water should be freshly prepared every 24 hours.
Slovenian: Vodo z zdravilom morate pripraviti na novo vsakih 24 ur.
English: Any unused product or waste material should be disposed of in accordance with national requirements.
Slovenian: Vsako neporabljeno zdravilo za uporabo v veterinarski medicini ali odpadne snovi, ki nastanejo iz teh zdravil, je treba odstraniti v skladu z nacionalnimi zahtevami.
English: Chickens: 5 days
Slovenian: Piščanci: 5 dni
English: As eradication of the target pathogens may not be achieved, medication should therefore be combined with good management practices, e.g. good hygiene, proper ventilation, no overstocking.
Slovenian: Ker popolnega uničenja ciljnega patogena morda ne bo mogoče doseči, je treba zdravilo kombinirati z dobro prakso upravljanja, npr. dobro higieno, ustreznim prezračevanjem, preprečevanjem prenapolnjenosti vzrejnega objekta.
English: Do not administer to animals with severe liver- or kidney insufficiency.
Slovenian: Ne dajajte živalim s hudo insuficienco jeter ali ledvic.
English: Goren E., Treatment of Infectious Disease Due to Bacteria in Commercial Poultry, Tijdschr.
Slovenian: 1 Goren E.: Treatment of Infectious Disease Due to Bacteria in Commercial Poultry.
English: List of the names, pharmaceutical form(s), strength of the veterinary medicinal products, animal species, route of administration, applicant/marketing authorisation holder in the member states
Slovenian: Seznam imen, farmacevtskih oblik, jakosti zdravila, živalskih vrst, poti uporabe zdravila in imetnikov dovoljenja za promet/predlagateljev
English: In view of the weaknesses in the existing data, the indications have been made more precise and SPC warnings and advice related to antimicrobial resistance have been strengthened.
Slovenian: Zaradi šibkih točk pri obstoječih podatkih so bile indikacije natančneje določene, v povzetku glavnih značilnosti zdravila pa so bila tudi okrepljena opozorila in nasveti v zvezi s protimikrobno odpornostjo.
English: No field trial data were submitted to support the use of the product in pigs.
Slovenian: Predloženi niso bili nobeni podatki iz terenskih preskušanj, ki bi podprli uporabo zdravila pri prašičih.
English: As pigs are a target species on all current SPCs (except for the product in the Netherlands), it was agreed that target species “pigs” can be accepted in the harmonised product information.
Slovenian: Ker so prašiči ciljna živalska vrsta v vseh trenutno veljavnih povzetkih glavnih značilnosti zdravila (razen za zdravilo na Nizozemskem), je bilo dogovorjeno, da se ciljna živalska vrsta „prašiči“ lahko potrdi v usklajenih informacijah o zdravilu.
English: Pharmacotherapeutic group: Antibacterial for systemic use, tetracyclines ATCvet-code: QJ01AA02
Slovenian: Farmakoterapevtska skupina: Protibakterijsko zdravilo za sistemsko uporabo, tetraciklini Oznaka ATCvet: QJ01AA02
English: Shelf life after reconstitution in milk replacer: use immediately.
Slovenian: Rok uporabnosti po rekonstituciji v mlečnem nadomestku: uporabite takoj.
English: Tetracycline resistance is usually acquired by means of plasmids or other mobile elements (e.g. conjugative transposones).
Slovenian: Odpornost na tetraciklin se ponavadi pridobi s pomočjo plazmidov ali drugih mobilnih elementov (npr. konjugativni transpozoni).
English: Data for some indications were absent, however, at the time of the Article 35 referral, there was no documented evidence in relation to suspected lack of expected efficacy of doxycycline products in chickens.
Slovenian: Podatkov za nekatere indikacije ni bilo, vendar pa v času napotitve v skladu s členom 35 ni bilo nobenih dokumentiranih dokazov glede domnevno manjše učinkovitosti zdravil z doksiciklinom od pričakovane pri piščancih.
English: SPECIAL WARNING(S) Read the package leaflet before use.
Slovenian: POSEBNO(A) OPOZORILO(A) Pred uporabo preberite navodila za uporabo.
English: Slightly yellowish powder.
Slovenian: Rahlo rumenkast prašek.
English: SPECIAL STORAGE CONDITIONS Store below 25 ºC.
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi pod 25 °C.
English: 4941 VX Raamsdonksveer The Netherlands
Slovenian: 4941 VX Raamsdonksveer Nizozemska
English: In contrast to the other tetracyclines, doxycycline is mainly excreted via the faeces.
Slovenian: Za razliko od drugih tetraciklinov se doksiciklin v glavnem izloča preko fecesa.
English: In order to help to ensure optimal bioavailability in the field, a warning has been included in section 4.8 of the SPC regarding the potential for doxycycline to chelate cations.
Slovenian: Da bi pomagali zagotoviti optimalno biološko razpoložljivost na terenu, je bilo v poglavje 4.8 povzetka glavnih značilnosti zdravila vključeno opozorilo glede potenciala doksiciklina za keliranje kationov.
English: Due to the greater liposolubility and greater facility to pass through cell membranes (in comparison to tetracycline), doxycycline retains a certain degree of efficacy against microorganisms with acquired resistance to tetracyclines.
Slovenian: Zaradi večje topnosti v maščobah in večje zmožnosti prehajanja skozi celične membrane (v primerjavi s tetraciklinom) ohrani doksiciklin določeno stopnjo učinkovitosti proti mikroorganizmov, ki so razvili odpornosti na tetracikline.
English: A study by Kuttler, 197813 showed that doxycycline was effective in moderating anaplasmosis in splenectomised calves infected with Anaplasma marginale.
Slovenian: Študija Kuttlerja, 197813, je pokazala, da je bil doksiciklin učinkovit pri uravnavanju anaplazmoze pri splenektomiranih teletih, okuženih z Anaplasma marginale.
English: Two literature references reported that doxycycline at 50 mg per litre in drinking water for 3 - 5 days was effective in treating challenge infections with E. coli (George, 19772) and E. coli and M. gallisepticum (Migaki, 19773).
Slovenian: V dveh referencah v literaturi so poročali, da je bil doksiciklin v odmerku 50 mg na liter pitne vode 3 do 5 dni učinkovit pri zdravljenju izzvanih okužb z E. coli (George, 19772) ter E. coli in M. gallisepticum (Migaki, 19773).
English: The distribution of doxycycline and penetration of doxycycline throughout most body tissues is good.
Slovenian: Porazdelitev doksiciklina in prodiranje doksiciklina v večino tkiv sta dobra.
English: Citric acid
Slovenian: Citronska kislina Laktoza
English: Food-borne, direct as well as environmental transmission of resistant microorganisms (resistant determinants) has to be considered a risk related to the use of the product despite the fact that quantification of transmission of zoonotic agents and horizontal transfer of resistance genes between animal and human bacteria is extremely difficult in vivo (F. J. Angulo et al., 2004)14.
Slovenian: Prenos s hrano ter neposredni in okoljski prenos odpornih mikroorganizmov (odporne determinante) se morajo upoštevati kot tveganje, povezano z uporabo zdravila, ne glede na to, da je kvantifikacija in vivo prenosa povzročiteljev zoonoze ter horizontalnega prenosa genov odpornosti med živalskimi in človeškimi bakterijami zelo težavna (F. J. Angulo et al., 2004)14.
English: It was agreed that the target species should be clarified to be “pre-ruminant calves” in the harmonised product information.
Slovenian: Dogovorjeno je bilo, da je treba ciljne živalske vrste pojasniti in v usklajenih informacijah o zdravilu navesti „teleta neprežvekovalci“.
English: The MIC90s values ranged from 0.03 μg/ml for Mycoplasma hyopneumoniae to 0.5 μg/ml for P. multocida.
Slovenian: Vrednosti MIC90s so se gibale med 0,03 μg/ml pri Mycoplasma hyopneumoniae in 0,5 μg/ml pri P. multocida.
English: Four resistance mechanisms acquired by microorganisms against tetracyclines in general have been reported: Decreased accumulation of tetracyclines (decreased permeability of the bacterial cell wall and active efflux), protein protection of the bacterial ribosome, enzymatic inactivation of the antibiotic and rRNA mutations (preventing the tetracycline binding to ribosome).
Slovenian: Poročali so o štirih mehanizmih odpornosti, ki so jih mikroorganizmi na splošno razvili proti tetraciklinom: Zmanjšano nabiranje tetraciklinov (zmanjšana prehodnost bakterijske celične stene in aktiven iztok), zaščita beljakovin bakterijskega ribosoma, encimska inkativacija antibiotika in mutacij rRNA (preprečevanje vezanja tetraciklinov na ribosome).
English: However, administration at 5 X and 10 X Recommended Treatment Dose was not well tolerated with animals showing anorexia, diarrhoea and evidence of renal failure necessitating euthanasia.
Slovenian: Pet- in desetkratnega priporočenega odmerka za zdravljenje pa niso dobro prenašale živali, ki so kazale znake anoreksije, driske in odpovedovanja ledvic, zaradi česar je bila potrebna evtanazija.
English: Do not use in conjunction with bactericidal antibiotics, such as penicillins and cephalosporins.
Slovenian: Ne uporabljajte v povezavi z baktericidnimi antibiotiki, kot so penicilini in cefalosporini.
English: Cross resistance between tetracyclines has also been described.
Slovenian: Opisali so tudi navzkrižno odpornost proti tetraciklinom.
English: In pigs, no accumulation of doxycycline in plasma was found after treatment via the drinking water.
Slovenian: Pri prašičih niso ugotovili zbiranja doksiciklina v plazmi po zdravljenju z dajanjem zdravila preko pitne vode.
English: Powder for administration in drinking water
Slovenian: Prašek za dajanje v pitno vodo
English: For the administration through the drinking water, the exact daily amount of product should be calculated, based on the recommended dose, and the number and weight of the animals to be treated, according to the following formula:
Slovenian: Za dajanje s pitno vodo je treba izračunati natančno dnevno količino zdravila glede na priporočeni odmerek, število in maso živali, ki jih boste zdravili, skladno s formulo:
English: The doxycycline plasma level reached an average of 2.2 to 2.5 μg/ml.
Slovenian: Koncentracija doksiciklina v plazmi je dosegla povprečno vrednost 2,2 do 2,5 μg/ml.
English: MIC data from literature for porcine respiratory tract pathogens isolated from clinical cases in the Netherlands were provided (Pijpers, 19905).
Slovenian: Predloženi so bili podatki o vrednostih MIC iz literature v zvezi s patogeni iz prašičjih dihal, izoliranimi v kliničnih primerih na Nizozemskem (Pijpers, 19905).
English: To be administered orally through the milk-replacer and/or the drinking water.
Slovenian: Za peroralno dajanje v mlečnem nadomestku in/ali pitni vodi.
English: PHARMACEUTICAL FORM Powder for oral solution.
Slovenian: FARMACEVTSKA OBLIKA Prašek za peroralno raztopino.
English: • Pleuropneumonia caused by Actinobacillus pleuropneumoniae.
Slovenian: • Plevropnevmonija, ki jo povzroča Actinobacillus pleuropneumoniae.
English: In addition, no evidence from pharmacovigilance of serious risk has been demonstrated to be associated with the current dosing regimens for chickens, pigs or pre-ruminant calves and as such they can be maintained.
Slovenian: Prav tako ni nobenih farmakovigilančnih dokazov, ki bi kazali na resno tveganje, povezano s trenutnim režimom odmerjanja za piščance, prašiče ali teleta neprežvekovalce, kar pomeni, da se tak način odmerjanja lahko ohrani.
English: A dose finding study by Pijpers, 1990b6, investigated the prophylactic effect of doxycycline in feed against challenge with Actinobacillus pleuropneumoniae.
Slovenian: V študiji za določanje odmerka avtorja Pijpersa, 1990b6, so primerjali profilaktični učinek doksiciklina v krmi z izzivom z Actinobacillus pleuropneumoniae.
English: • Enteritis caused by Clostridium perfringens and Clostridium colinum.
Slovenian: • Enteritis, ki ga povzročata Clostridium perfringens in Clostridium colinum.
English: Interactions with other medicinal products and other forms of interaction Do not use in conjunction with bactericidal antibiotics, such as penicillins and cephalosporins.
Slovenian: Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Ne uporabljajte v povezavi z baktericidnimi antibiotiki, kot so penicilini in cefalosporini.
English: In this study, doses of doxycycline equivalent to 16, 7.5 and 3.6 mg/kg body weight/day were effective in preventing disease in 6/6, 5/6 and 1/6 pigs, respectively.
Slovenian: V tej študiji se je pokazalo, da so bili odmerki doksiciklina, ki so enakovredni 16, 7,5 oz. 3,6 mg na kg telesne mase na dan, učinkoviti pri preprečevanju bolezni pri 6/6, 5/6 oz. 1/6 prašičev.
English: It inhibits bacterial protein synthesis intracellularly by binding on the 30-S ribosome subunits.
Slovenian: Zavira znotrajcelično sintezo bakterijskih beljakovin, tako da se veže na ribosomske podenote 30-S.
English: 4941 VX Raamsdonksveer The Netherlands research@dopharma.com
Slovenian: 4941 VX Raamsdonksveer Nizozemska research@dopharma.com
English: The main sections of disharmony of the existing SPCs were:
Slovenian: Največja neskladja med obstoječimi povzetki glavnih značilnosti zdravila so bila pri:
English: This interferes with binding of aminoacetyl-tRNA to the acceptor site on the mRNA ribosome complex and prevents coupling of amino acids to the elongating peptide chains.
Slovenian: To moti vezanje aminoacetila-tRNA na sprejemno mesto na kompleksu ribosoma in mRNA in preprečuje spajanje aminokislin z nastajajočimi peptidnimi verigami.
English: STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENT(S) Active substance:
Slovenian: NAVEDBA ZDRAVILNE UČINKOVIN(E) IN DRUGE(IH) SNOVI
English: No Minimum Inhibitory Concentration (MIC) data were submitted that were specifically relevant to isolates from target pathogens from chickens.
Slovenian: Predloženi niso bili nobeni podatki glede minimalne inhibitorne koncentracije (MIC), ki bi bili posebej pomembni za izolate iz ciljnih patogenov pri piščancih.
English: A Good Clinical Practice standard field study was provided investigating the efficacy of Doxycycline 50% WSP to treat naturally occurring outbreaks of colibacillosis on 5 farms in The Netherlands in 1998.
Slovenian: Predložena je bila tudi terenska študija, ki so jo opravili v skladu s standardi dobre klinične prakse in s katero so preučevali učinkovitost zdravila Doxycycline 50% WSP za zdravljenje naravnih izbruhov kolibaciloze na petih farmah na Nizozemskem leta 1998.
English: 4.4 Special warnings for each target species
Slovenian: 4.4 Posebna opozorila za posamezne ciljne živalske vrste Jih ni.
English: Data from Goren, 19831, on the in vitro susceptibility of pathogens isolated from poultry between 1978 and 1981 showed that susceptibility of P. multocida was > 70%, but that of E. coli varied between 4 to 34% over the time period studied.
Slovenian: Podatki avtorja Gorena1, 1983, o občutljivosti in vitro patogenov, izoliranih iz piščancev med letoma 1978 in 1981, so pokazali, da je bila občutljivost P. multocida > 70 %, občutljivost E. coli pa je v preučevanem obdobju nihala med 4 in 34 %.
English: High levels of resistance to tetracyclines in swine respiratory pathogens have also been documented (ARBAO-II study, 2008)7.
Slovenian: Dokumentirane so bile visoke stopnje odpornosti na tetracikline pri prašičjih respiratornih patogenih (študija ARBAO-II, 2008).
English: Doxycycline is a broad spectrum antibiotic.
Slovenian: Doksiciklin je antibiotik s širokim spektrom delovanja.
English: 8 Meijer et al, Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves, Vet. Quart.
Slovenian: Meijer et al, Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves.