FrancophonIA/ELRC3.0 huggingface dataset:
English: There was one case of discontinuation in a patient receiving the 70 mg dose due to injection site rash.
Croatian: Bio je jedan slučaj prekida primjene lijeka u bolesnika koji je primao dozu od 70 mg zbog osipa na mjestu primjene injekcije.
English: Each pre-filled syringe is for single use only and designed to deliver the entire contents with no residual content remaining.
Croatian: Jedna napunjena štrcaljka namijenjena je samo za jednokratnu uporabu i izrađena tako da isporuči cjelokupni sadržaj bez da išta sadržaja preostane.
English: No studies have been performed in patients with hepatic impairment.
Croatian: Nisu provedena ispitivanja u bolesnika s oštećenjem jetre.
English: See section “Injection site reactions” below.
Croatian: Vidjeti dio “Reakcije na mjestu primjene injekcije” u nastavku.
English: White cap off
Croatian: Bijela kapica skinuta
English: Illustration of the Aimovig 70 mg pen (with light blue body, purple start button, white cap and green safety guard)
Croatian: Ilustracija Aimovig 70 mg brizgalice (sa svijetloplavim tijelom, ljubičastom tipkom za aktivaciju, bijelom kapicom i zelenim štitnikom)
English: Erenumab exhibits non-linear kinetics as a result of binding to the CGRP-R receptor.
Croatian: Erenumab pokazuje nelinearnu kinetiku uslijed vezanja za CGRP-R receptor.
English: Figure 2 Change from baseline in monthly migraine days over time in Study 2 (including primary endpoint over Months 4, 5 and 6)
Croatian: Slika 2 Promjena u danima migrene mjesečno tijekom vremena u odnosu na početnu vrijednost u Ispitivanju 2 (uključujući primarnu mjeru ishoda tijekom 4., 5. i 6. mjeseca)
English: Pooled across the two doses, a reduction of -9.3 MMD was observed after 52 weeks relative to core study baseline.
Croatian: Prikupljeno u zbirnim podacima za obje doze, uočeno je smanjenje od -9,3 DMM nakon 52 tjedna u odnosu na početnu vrijednost glavnog ispitivanja.
English: In all cases described above, use a new pen, and if you are unsure contact your doctor or pharmacist.
Croatian: U svim opisanim slučajevima upotrijebite novu brizgalicu, a ako niste sigurni obratite se svom liječniku ili ljekarniku.
English: Do not twist or bend the grey needle cap.
Croatian: Ne okrećite ni ne savijajte sivu kapicu igle.
English: Comprehensive instructions for administration are given in the instructions for use in the package leaflet.
Croatian: Sveobuhvatne upute za primjenu navedene su u uputama za uporabu u uputi o lijeku.
English: The reduction in monthly migraine days from baseline to Week 52 was -4.22 in the 70 mg ATP group and -4.64 days in the 140 mg ATP group.
Croatian: Smanjenje u danima migrene mjesečno u odnosu na početne vrijednosti u 52. tjednu bilo je -4,22 u ATP grupi od 70 mg te -4,64 dana u ATP grupi od 140 mg.
English: Stretch or pinch the injection site to create a firm surface.
Croatian: Rastegnite ili uštipnite kožu na mjestu primjene injekcije da dobijete čvrstu površinu.
English: Treatment difference (95% CI)
Croatian: Razlika u liječenju (95% CI)
English: 667 patients were randomised in a 3:2:2 ratio to receive placebo (n = 286) or 70 mg (n = 191) or 140 mg (n = 190) erenumab, stratified by the presence of acute medication overuse (present in 41% of overall patients).
Croatian: 667 bolesnika bilo je randomizirano u omjeru 3:2:2 na primanje placeba (n = 286) ili 70 mg (n = 191) ili 140 mg (n = 190) erenumaba, stratificirano prema prisutnosti akutne prekomjerne uporabe lijekova (prisutne u 41% svih bolesnika).
English: 955 patients were randomised in a 1:1:1 ratio to receive 140 mg (n = 319) or 70 mg (n = 317) erenumab or placebo (n = 319).
Croatian: 955 bolesnika bilo je randomizirano u omjeru 1:1:1 na primanje 140 mg (n = 319) ili 70 mg (n = 317) erenumaba ili placeba (n = 319).
English: In repeated-dose toxicology studies there were no adverse effects in sexually mature monkeys dosed up to 150 mg/kg subcutaneously twice weekly for up to 6 months at systemic exposures up to 123-fold and 246-fold higher than the clinical dose of 140 mg and 70 mg, respectively, every 4 weeks, based on serum AUC.
Croatian: U toksikološkim ispitivanjima ponovljenih doza nije bilo štetnih učinaka u spolno zrelih majmuna koji su primali do 150 mg/kg supkutano dvaput tjedno u razdoblju do 6 mjeseci pri sistemskim izloženostima do 123 puta odnosno 246 puta višima od kliničke doze od 140 mg odnosno 70 mg, svaka 4 tjedna, na temelju serumskog AUC-a.
English: At Week 52, the proportion of subjects who achieved a ≥50% reduction in MMD from baseline was 61.0% in the 70 mg ATP and 64.9% in the 140 mg ATP group.
Croatian: U 52. tjednu udio ispitanika koji su postigli smanjenje od ≥50% DMM-a u odnosu na početne vrijednosti bio je 61,0% u ATP grupi od 70 mg te 64,9% u ATP grupi od 140 mg.
English: After removal from the refrigerator, Aimovig must be used within 14 days when stored at room temperature (up to 25°C), or discarded.
Croatian: Nakon što se izvadi iz hladnjaka, Aimovig se mora upotrijebiti u roku od 14 dana ako se čuva na sobnoj temperaturi (do 25°C) ili baciti.
English: Do not recycle the syringe or sharps disposal container, or throw them into household waste.
Croatian: Nemojte reciklirati štrcaljku ili spremnik za oštre predmete ili ih bacati u kućanski otpad.
English: Episodic migraine
Croatian: Epizodne migrene
English: Aimovig (erenumab) was evaluated as monotherapy for prophylaxis of chronic migraine in a randomised, multicentre, 12-week, placebo-controlled, double-blind study in patients suffering from migraine with or without aura (≥15 headache days per month with ≥8 migraine days per month).
Croatian: Aimovig (erenumab) se procjenjivao kao monoterapija za profilaksu kronične migrene u randomiziranom, multicentričnom, 12-tjednom, placebom kontroliranom, dvostruko slijepom ispitivanju u bolesnika koji boluju od migrene sa ili bez aure (≥15 dana glavobolje mjesečno uz ≥8 dana migrene mjesečno).
English: Inspect the syringe(s).
Croatian: Pregledajte brizgalicu(e).
English: Aimovig syringes are for single use only.
Croatian: Aimovig štrcaljke namijenjene su samo za jednokratnu uporabu.
English: Multipack containing 3 (3x 1) pre-filled pens
Croatian: Višestruko pakiranje koje sadrži 3 (3x 1) napunjene brizgalice
English: Discard the used syringe and the grey needle cap.
Croatian: Zbrinite iskorištenu štrcaljku i sivu kapicu igle.
English: For MIDAS: Change and reduction from baseline were evaluated over 24 weeks.
Croatian: Za MIDAS: promjena i smanjenje u odnosu na početnu vrijednost procijenjeni su tijekom 24 tjedna.
English: In a reproduction study in cynomolgus monkeys there were no effects on pregnancy, embryo-foetal or post-natal development (up to 6 months of age) when erenumab was dosed throughout pregnancy at exposure levels approximately 17-fold and 34-fold higher than those achieved in patients receiving erenumab 140 mg and 70 mg, respectively, every 4 weeks dosing regimen based on AUC.
Croatian: U ispitivanju reprodukcije u cynomolgus majmuna nije bilo učinaka na trudnoću, embrio-fetalni ili postnatalni razvoj (do starosti od 6 mjeseci) kad je erenumab bio doziran tijekom trudnoće pri razinama izloženosti koje su bile otprilike 17 puta odnosno 34 puta više od onih postignutih u bolesnika koji su primali 140 mg odnosno 70 mg erenumaba svaka 4 tjedna na temelju AUC-a.
English: Less than 2-fold accumulation was observed in trough serum concentrations following 140 mg doses administered subcutaneously every 4 weeks and serum trough concentrations approached steady state by 12 weeks of dosing.
Croatian: Manje od dvostruke akumulacije opaženo je u najnižim koncentracijama u serumu nakon doza od 140 mg primijenjenih supkutano svaka 4 tjedna, a najniže koncentracije u serumu približile su se stanju dinamičke ravnoteže nakon 12 tjedana doziranja.
English: Stomach area (abdomen) (except for a 5 cm area around the navel) Outer area of upper arm (only if someone else is giving you the injection)
Croatian: Možete upotrijebiti bilo koje od sljedećih mjesta za primjenu injekcije: bedro područje trbuha (abdomen) (osim područja 5 cm oko pupka) vanjski dio nadlaktice (samo ako Vam netko drugi daje injekciju)
English: After Aimovig has been taken out of the refrigerator, it must be kept at room temperature (up to 25°C) in the outer carton and must be used within 14 days, or else discarded.
Croatian: Nakon što se Aimovig izvadi iz hladnjaka, mora se držati na sobnoj temperaturi (do 25°C) u vanjskoj kutiji i mora se upotrijebiti u roku od 14 dana ili baciti.
English: For exploratory endpoints, no p-value is presented.
Croatian: Za eksploratorne mjere ishoda nije prikazana nikakva p-vrijednost.
English: Do not put the grey needle cap back onto the syringe once it has been removed.
Croatian: Ne vraćajte sivu kapicu igle na štrcaljku nakon što ste je skinuli.
English: Aimovig is used to prevent migraine in adults who have at least 4 migraine days per month when starting treatment with Aimovig.
Croatian: Aimovig se koristi za sprječavanje migrene u odraslih koji imaju najmanje 4 dana migrene mjesečno kad počinju liječenje Aimovigom.
English: Within each system organ class, the ADRs are ranked by frequency, with the most frequent reactions first.
Croatian: Unutar svake klasifikacije organskog sustava nuspojave su poredane po učestalosti, počevši od najučestalijih.
English: There were 117 cases with 130 adverse events of hypersensitivity in the MAH's global safety database.
Croatian: U globalnoj sigurnosnoj bazi podataka nositelja odobrenja bilo je 117 slučajeva sa 130 nuspojava preosjetljivosti.
English: For MIDAS: Change and reduction from baseline were evaluated over 12 weeks.
Croatian: Za MIDAS: promjena i smanjenje u odnosu na početnu vrijednost procijenjeni su tijekom 12 tjedana.
English: INTERMEDIATE CARTON OF MULTIPACK (WITHOUT BLUE BOX) - pre-filled pen
Croatian: SREDNJA KUTIJA VIŠESTRUKOG PAKIRANJA (BEZ PLAVOG OKVIRA) - napunjena brizgalica
English: Pull the cap straight off, only when you are ready to inject.
Croatian: Skinite kapicu povlačenjem s brizgalice tek kad ste spremni za injekciju.
English: How to store Aimovig
Croatian: Kako čuvati Aimovig
English: Aimovig is available in packs containing 1 pre-filled syringe.
Croatian: Aimovig je dostupan u pakiranjima koja sadrže 1 napunjenu štrcaljku.
English: Aimovig (erenumab) was evaluated for prophylaxis of episodic migraine in a randomised, multicentre, 24-week, placebo-controlled, double-blind study in patients suffering from migraine with or without aura (4-14 migraine days per month).
Croatian: Aimovig (erenumab) se procjenjivao za profilaksu epizodne migrene u randomiziranom, multicentričnom, 24-tjednom, placebom kontroliranom, dvostruko slijepom ispitivanju u bolesnika koji boluju od migrene s aurom ili bez nje (4-14 dana migrene mjesečno).
English: Aimovig contains sodium Aimovig contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially “sodium-free”.
Croatian: Aimovig sadrži manje od 1 mmol (23 mg) natrija po dozi, tj. zanemarive količine natrija.
English: Aimovig pens are for single use only.
Croatian: Aimovig brizgalice namijenjene su samo za jednokratnu uporabu.
English: Erenumab is a fully human IgG2 monoclonal antibody produced using recombinant DNA technology in Chinese hamster ovary (CHO) cells.
Croatian: Erenumab je potpuno humano IgG2 monoklonsko protutijelo proizvedeno na stanicama jajnika kineskog hrčka (engl.
English: Instructions for use of Aimovig pre-filled pens
Croatian: Upute za uporabu Aimovig napunjene brizgalice
English: In the clinical studies, the incidence of anti-erenumab antibody development during the double-blind treatment phase was 6.3% (56/884) among subjects receiving a 70 mg dose of erenumab (3 of whom had in vitro neutralising activity) and 2.6% (13/504) among subjects receiving a 140 mg dose of erenumab (none of whom had in vitro neutralising activity).
Croatian: U kliničkim ispitivanjima incidencija razvoja protutijela na erenumab tijekom faze dvostruko slijepog liječenja bila je 6,3% (56/884) među ispitanicima koji su primali dozu erenumaba od 70 mg (od kojih je 3 imalo in vitro neutralizirajuću aktivnost) i 2,6% (13/504) među ispitanicima koji su primali dozu erenumaba od 140 mg (od kojih nijedan nije imao in vitro neutralizirajuću aktivnost).
English: Remove Aimovig pre-filled syringe(s) from the carton by holding it/them at the barrel.
Croatian: Izvadite Aimovig napunjenu štrcaljku(e) iz pakiranja držeći je/ih za tijelo.
English: Put the used syringe in a sharps disposal container immediately after use.
Croatian: Stavite iskorištenu brizgalicu u spremnik za odlaganje oštrih predmeta odmah nakon uporabe.
English: Figure 1 Change from baseline in monthly migraine days over time in Study 1 (including primary endpoint at Month 3)
Croatian: Slika 1 Promjena u broju dana migrene mjesečno tijekom vremena u odnosu na početnu vrijednost u Ispitivanju 1 (uključujući primarnu mjeru ishoda u 3. mjesecu)
English: How to use Aimovig
Croatian: Kako primjenjivati Aimovig
English: What Aimovig looks like and contents of the pack Aimovig solution for injection is clear to opalescent, colourless to light yellow, and practically free from particles.
Croatian: Aimovig otopina za injekciju je bistra do opalescentna, bezbojna do svijetlo žuta te praktički bez čestica.
English: Do not use the syringe if the needle cap is missing or is not securely attached.
Croatian: Ne upotrebljavajte štrcaljku ako nema kapicu igle ili ako kapica nije sigurno pričvršćena.
English: Pinch method Pinch skin firmly between your thumb and fingers, creating an area about five cm wide.
Croatian: Čvrsto uštipnite kožu između palca i prstiju kako biste dobili područje široko oko pet cm.
English: Note: Needle is inside the pen.
Croatian: Napomena: igla se nalazi u brizgalici.
English: Illustration of the Aimovig 140 mg pen (with dark blue body, grey start button, orange cap and yellow safety guard)
Croatian: Ilustracija Aimovig 140 mg brizgalice (s tamnoplavim tijelom, sivom tipkom za aktivaciju, narančastom kapicom i žutim štitnikom)
English: OUTER CARTON OF MULTIPACK (INCLUDING BLUE BOX) - pre-filled pen
Croatian: VANJSKA KUTIJA VIŠESTRUKOG PAKIRANJA (UKLJUČUJUĆI PLAVI OKVIR)napunjena brizgalica
English: If your doctor prescribes the 140 mg dose you should have either one injection of Aimovig 140 mg or two injections of Aimovig 70 mg once every 4 weeks.
Croatian: Ako Vaš liječnik propiše dozu od 140 mg, trebate primiti ili jednu injekciju Aimoviga 140 mg ili dvije injekcije Aimoviga 70 mg jedanput svaka 4 tjedna.
English: Each 140 mg dose is given either as one subcutaneous injection of 140 mg or as two subcutaneous injections of 70 mg.
Croatian: Jedna doza od 140 mg se daje ili kao jedna supkutana injekcija od 140 mg ili kao dvije supkutane injekcije od 70 mg.
English: Efficacy outcomes MMD
Croatian: Ishodi u pogledu djelotvornosti DMM
English: Make sure the solution you see in the window is clear and colourless to light yellow.
Croatian: Provjerite da je otopina koju vidite u prozorčiću bistra i bezbojna do svijetlo žuta.
English: Erenumab is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor.
Croatian: Erenumab je humano monoklonsko protutijelo koje se veže za receptor peptida povezanog s kalcitoninskim genom (engl. calcitonin gene-related peptide, CGRP).
English: No effect on exposure of co-administered medicinal products is expected based on the metabolic pathways of monoclonal antibodies.
Croatian: Na osnovu metaboličkih puteva monoklonskih protutijela ne očekuje se učinak na izloženost istodobno primijenjenih lijekova.
English: Aimovig is supplied in a pre-filled syringe (1 ml, Type 1 glass) with a stainless steel needle and a needle cover (rubber containing latex).
Croatian: Aimovig se isporučuje u napunjenoj štrcaljki (1 ml, staklo tipa 1) s iglom od nehrđajućeg čelika i pokrovom igle (guma koja sadrži lateks).
English: If your dose is 140 mg and you are using two Aimovig 70 mg pens, repeat steps 1(D) to 4 with the second pen to inject the full dose.
Croatian: Ako je Vaša doza 140 mg i koristite dvije brizgalice Aimoviga 70 mg, ponovite korake od 1(D) do 4 s drugom brizgalicom da biste ubrizgali cijelu dozu.
English: If your dose is 140 mg and you are using two Aimovig 70 mg syringes, repeat steps 1(D) to 4 with the second syringe to inject the full dose.
Croatian: Ako je Vaša doza 140 mg i koristite dvije štrcaljke Aimoviga 70 mg, ponovite korake od 1(D) do 4 s drugom štrcaljkom da biste ubrizgali cijelu dozu.
English: Table 3 Change from baseline in efficacy and patient-reported outcomes at Weeks 13-24 in Study 2
Croatian: Tablica 3 Promjena u djelotvornosti i ishodima prema procjeni bolesnika od početne vrijednosti u tjednima 13.-24. u Ispitivanju 2
English: Within each frequency grouping, adverse drug reactions are presented in order of decreasing seriousness.
Croatian: Unutar jedne skupine po učestalosti, nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
English: Step 3: Inject
Croatian: 3. korak: ubrizgajte lijek
English: Used plunger Finger flange
Croatian: Iskorišteni klip Oslonac za prste
English: The mean migraine frequency at baseline was approximately 18 migraine days per month.
Croatian: Srednja učestalost migrene na početku bila je otprilike 18 dana migrene mjesečno.
English: The mean migraine frequency at baseline was approximately 8 migraine days per month.
Croatian: Srednja učestalost migrene na početku bila je otprilike 8 dana migrene mjesečno.
English: Carefully lift Aimovig pre-filled pen(s) out of the carton.
Croatian: Pažljivo izvadite Aimovig napunjenu brizgalicu(e) iz pakiranja.
English: The reported adverse drug reactions for 70 mg and 140 mg were injection site reactions (5.6%/4.5%), constipation (1.3%/3.2%), muscle spasms (0.1%/2.0%) and pruritus (0.7%/1.8%).
Croatian: Prijavljene nuspojave za 70 mg i 140 mg bile su reakcije na mjestu primjene injekcije (5,6%/4,5%), konstipacija (1,3%/3,2%), mišićni spazmi (0,1%/2,0%) i pruritus (0,7%/1,8%).
English: The container of this medicinal product contains latex rubber within the cap. - if you suffer from a cardiovascular disease.
Croatian: Spremnik ovog lijeka sadrži lateks od prirodne gume unutar kapice.
English: Aimovig is supplied in a pre-filled pen (1 ml, Type 1 glass) with a stainless steel needle and a needle cover (rubber containing latex).
Croatian: Aimovig se isporučuje u napunjenoj brizgalici (1 ml, staklo tipa 1) s iglom od nehrđajućeg čelika i pokrovom igle (guma koja sadrži lateks).
English: The solution is clear to opalescent, colourless to light yellow.
Croatian: Otopina je bistra do opalescentna, bezbojna do svijetlo žuta.
English: Driving and using machines Aimovig is unlikely to affect your ability to drive and use machines.
Croatian: Mala je vjerojatnost da će Aimovig utjecati na Vašu sposobnost upravljanja vozilima i strojevima.
English: Yellow safety guard
Croatian: Žuti štitnik
English: Note: Do not touch the start button yet.
Croatian: Napomena: ne dirajte još tipku za aktivaciju.
English: Make sure the solution you see in the syringe is clear and colourless to light yellow.
Croatian: Provjerite da je otopina koju vidite u štrcaljki bistra i bezbojna do svijetlo žuta.
English: Aimovig is available in packs containing 1 pre-filled pen and in multipacks containing 3 (3x1) pre-filled pens.
Croatian: Aimovig je dostupan u pakiranjima koja sadrže 1 napunjenu brizgalicu te u višestrukim pakiranjima koja sadrže 3 (3x1) napunjene brizgalice.
English: Aimovig is available in packs containing one single-use pre-filled pen and in multipacks containing 3 (3x1) pre-filled pens.
Croatian: Aimovig je dostupan u pakiranjima koja sadrže jednu napunjenu brizgalicu za jednokratnu uporabu te u višestrukim pakiranjima koja sadrže 3 (3x1) napunjene brizgalice.
English: Each pack contains one single-use pre-filled syringe.
Croatian: Jedno pakiranje sadrži jednu napunjenu štrcaljku za jednokratnu uporabu.
English: This means that for the 70 mg dose you must inject the contents of one 70 mg single-use syringe.
Croatian: To znači da za dozu od 70 mg morate ubrizgati sadržaj jedne brizgalice za jednokratnu uporabu od 70 mg.
English: Mean change (95% CI)
Croatian: Srednja promjena (95% CI)
English: Note: Do not try to warm the syringe(s) by using a heat source such as hot water or microwave.
Croatian: Napomena: Ne pokušavajte zagrijati štrcaljku(e) koristeći izvor topline kao što je vruća voda ili mikrovalna pećnica.
English: Do not put the cap back onto the pen once it has been removed.
Croatian: Ne vraćajte kapicu na brizgalicu nakon što ste je skinuli.
English: Orange cap off
Croatian: Narančasta kapica skinuta
English: However, at therapeutically relevant doses, the pharmacokinetics of erenumab following subcutaneous dosing every 4 weeks are predominantly linear due to saturation of binding to CGRP-R. Subcutaneous administration of a 140 mg once monthly dose and a 70 mg once monthly dose in healthy volunteers resulted in a Cmax mean (standard deviation [SD]) of 15.8 (4.8) µg/ml and 6.1 (2.1) µg/ml, respectively, and AUClast mean (SD) of 505 (139) day*µg/ml and 159 (58) day*µg/ml, respectively.
Croatian: Supkutana primjena doze od 140 mg jednom mjesečno i doze od 70 mg jednom mjesečno u zdravih dobrovoljaca rezultirala je srednjim Cmax (standardna devijacija [SD]) od 15,8 (4,8) µg/ml odnosno 6,1 (2,1) µg/ml i srednjim AUClast (SD) od 505 (139) dan*µg/ml odnosno 159 (58) dan*µg/ml.
English: Table 2 Change from baseline in efficacy and patient-reported outcomes at Week 12 in Study 1
Croatian: Tablica 2 Promjena u djelotvornosti i ishodima prema procjeni bolesnika od početne vrijednosti do 12. tjedna u Ispitivanju 1
English: Pack containing 1 pre-filled pen
Croatian: Pakiranje koje sadrži 1 napunjenu brizgalicu
English: The solution should not be injected if it is cloudy, distinctly yellow or contains flakes or particles.
Croatian: Ako je otopina zamućena, izrazito žuta ili sadrži pahuljice ili čestice, ne smije se ubrizgati.
English: Do not rub the injection site.
Croatian: Nemojte trljati mjesto primjene.
English: The entire contents of the Aimovig pre-filled pen should be injected.
Croatian: Potrebno je ubrizgati sav sadržaj napunjene brizgalice Aimoviga.
English: The syringe(s) must not be warmed by using a heat source such as hot water or microwave and must not be shaken.
Croatian: Brizgalica(e) se ne smije zagrijavati pomoću izvora topline kao što je vruća voda ili mikrovalna pećnica i ne smiju se tresti.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE NALJEPNICA ŠTRCALJKE
English: Aimovig contains the active substance erenumab.
Croatian: Aimovig sadrži djelatnu tvar erenumab.
English: The treatment difference observed between erenumab 140 mg and placebo and between erenumab 70 mg and placebo for the reduction of MMD in these patients was -3.1 days (95% CI: -4.8, -1.4) in both cases, and for the reduction of acute migraine-specific medication days was -2.8 (95% CI: -4.2, -1.4) for 140 mg and -3.3 (95% CI: -4.7, -1.9) for 70 mg.
Croatian: Razlika u liječenju opažena između erenumaba 140 mg i placeba i između erenumaba 70 mg i placeba za smanjenje DMM-a u ovih bolesnika bila je -3,1 dana (95% CI: -4,8; -1,4) u oba slučaja, a za smanjenje dana akutne medikacije za migrenu bila je -2,8 (95% CI: -4,2; -1,4) za 140 mg i -3,3 (95% CI: -4,7; -1,9) za 70 mg.
English: Aimovig is for subcutaneous use.
Croatian: Način primjene Aimovig je namijenjen za supkutanu primjenu.
English: Pack containing 1 pre-filled syringe
Croatian: Pakiranje koje sadrži 1 napunjenu štrcaljku
English: Common a
Croatian: Pruritus a
English: The entire contents of the Aimovig pre-filled syringe should be injected.
Croatian: Potrebno je ubrizgati sav sadržaj napunjene štrcaljke Aimoviga.
English: Aimovig 70 mg solution for injection in pre-filled syringe Aimovig 140 mg solution for injection in pre-filled syringe Aimovig 70 mg solution for injection in pre-filled pen Aimovig 140 mg solution for injection in pre-filled pen
Croatian: Aimovig 70 mg otopina za injekciju u napunjenoj štrcaljki Aimovig 140 mg otopina za injekciju u napunjenoj štrcaljki Aimovig 70 mg otopina za injekciju u napunjenoj brizgalici Aimovig 140 mg otopina za injekciju u napunjenoj brizgalici