FrancophonIA/ELRC3.0 huggingface dataset:
English: The starting dosage in adults is 750 mg/day, in three divided doses provided that it is sufficient to normalise serum cholestanol and/or urine bile alcohols.
Croatian: Početna doza kod odraslih je 750 mg/dan, u tri podijeljene doze pod uvjetom da je to dovoljno za normaliziranje serumskog kolestanola i/ili žučnih alkohola u urinu.
English: Capsule contents: maize starch, magnesium stearate, silica colloidal anhydrous, water,
Croatian: Sadržaj kapsule: kukuruzni škrob, magnezijev stearat, silicijev dioksid koloidni bezvodni, voda,
English: Two intrauterine deaths in a mother with CTX have been reported in the literature.
Croatian: U literaturi su zabilježene dvije unutarmaternične smrti kod majki s CTX-om.
English: Chenodeoxycholic acid is indicated for the treatment of inborn errors of primary bile acid synthesis due to sterol 27 hydroxylase deficiency (presenting as cerebrotendinous xanthomatosis (CTX)) in infants, children and adolescents aged 1 month to 18 years and adults.
Croatian: Kenodeoksikolatna kiselina je indicirana za liječenje urođenih grešaka sinteze primarne žučne kiseline uzrokovanih nedostatkom sterol 27 hidroksilaze (što se iskazuje kao cerebrotendinozna ksantomatoza (CTX)) kod dojenčadi, djece i adolescenata starosti od 1 mjeseca do 18 godina te kod odraslih.
English: Rodent and primate toxicity species lack efficient-sulfating capacity for conjugation of lithocholic acid, and therefore have shown hepatotoxicity.
Croatian: Glodavci i primati za ispitivanja toksičnosti nemaju sposobnost djelotvorne sulfatacije za konjugaciju litokolatne kiseline, pa se radi toga kod njih pojavila hepatoksičnost.
English: The infant's liver function normalised upon temporarily stopping treatment with Chenodeoxycholic acid.
Croatian: Funkcija jetre dojenčeta se normalizirala nakon privremenog prestanka liječenja kenodeoksikolatnom kiselinom.
English: The maximum dose for children is 15 mg per kg per day.
Croatian: Maksimalna doza za djecu je 15 mg po kg na dan.
English: Oral contraceptives therefore may worsen the underlying deficiency and counteract the effectiveness of chenodeoxycholic acid in CTX.
Croatian: Prema tome, oralni kontraceptivi mogu pogoršati prisutni nedostatak i poništiti učinkovitost kenodeoksikolatne kiseline u CTX-u.
English: Reduced production of cholesterol: reduces serum cholestanol (action on HMG CoA reductase).
Croatian: Smanjeno stvaranje kolesterola: smanjuje serumski kolestanol (djelovanje na HMG CoA reduktazu).
English: Capsule shell Gelatine
Croatian: Ovojnica kapsule Želatina
English: Chenodeoxycholic acid Leadiant should be used under medical supervision.
Croatian: Chenodeoxycholic acid Leadiant treba koristiti uz nadzor liječnika.
English: Contents of the pack and other information - What Chenodeoxycholic acid Leadiant contains
Croatian: Sadržaj pakiranja i druge informacije - Što sadrži Chenodeoxycholic acid Leadiant
English: Colestipol or antacid medicinal products containing aluminium hydroxide and/or smectite should be taken either 2 hours before or after taking chenodeoxycholic acid.
Croatian: Kolestipol ili antacide koji sadrže aluminijev hidroksid i/ili smektit treba uzeti ili 2 sata prije ili nakon uzimanja kenodeoksikolatne kiseline.
English: In CTX, a defect in the CYP27A1 gene results in a deficient mitochondrial sterol 27-hydroxylase enzyme.
Croatian: Kod CTX-a, greška u genu za CYP27A1 rezultira nedostatkom mitohondrijskog enzima sterol 27
English: Chenodeoxycholic acid Leadiant is not expected to affect your ability to drive or use machines.
Croatian: Ne očekuje se da će Chenodeoxycholic acid Leadiant utjecati na Vašu sposobnost upravljanja vozilima ili rada sa strojevima.
English: Effects of chenodeoxycholic acid with other medicinal products Co-administration with ciclosporin, sirolimus, phenobarital is not recommended, see section 4.5 for further details.
Croatian: Učinci kenodeoksikolatne kiseline s drugim lijekovima Ne preporučuje se istodobna primjena s ciklosporinom, sirolimusom i fenobarbitalom, pogledajte dio 4.5 za dodatne informacije.
English: Dose calculation (Children 1-12yr, adolescents 12-18yr and adults) chenodeoxycholic acid 10 mg/mL suspension
Croatian: Izračunavanje doze (Djeca 1-12 godina, adolescenti 12-18 godina i odrasli) suspenzija koja sadrži 10 mg/ml kenodeoksikolatne kiseline
English: There was a statistically significant (p = 0.04) improvement (decrease) of -0.31 ± 0.48 in the mean Rankin score for the < 21 years of age subgroup.
Croatian: (smanjenja) od -0,31 ± 0,48 u srednoj vrijednosti rezultata na Rankin ljestvici za podskupinu < 21 godine.
English: If it is necessary to take a medicinal product containing one of these active substances it should be taken either 2 hours before or after taking chenodeoxycholic acid.
Croatian: Ako je potrebno uzeti lijek koji sadrži jednu od navedenih djelatnih tvari, treba ga uzeti 2 sata prije ili nakon uzimanja kenodeoksikolatne kiseline.
English: Treatment must be initiated and monitored by physicians experienced in the management of CTX or inborn errors of primary bile acid synthesis.
Croatian: 4.2 Doziranje i način primjene Liječenje moraju započeti i nadzirati liječnici koji imaju iskustva u liječenju CTX-a ili urođenih grešaka sinteze primarne žučne kiseline.
English: The active substance will be dissolved in the sodium bicarbonate solution and as not all the contents of the capsule will be dissolved it appears as a mixture.
Croatian: Sama djelatna tvar će se otopiti u otopini natrijevog bikarbonata, a budući se neće otopiti svi dijelovi sadržaja kapsule, izgledat će kao suspenzija.
English: In CTX, deficiency of chenodeoxycholic acid causes a lack of feedback of cholesterol 7 alpha hydroxylase (CYP7A1) and HMG CoA reductase, causing increased production of atypical bile acids, bile alcohols and cholestanol that lead to the pathological consequences of the condition.
Croatian: U CTX-u nedostatak kenodeoksikolatne kiseline uzrokuje nedostatak povratne sprege kolesterol 7 alfa hidroksilaze (CYP7A1) i HMG Co A reduktaze, što vodi do povećanog stvaranja atipičnih žučnih kiselina, žučnih alkohola i kolestanola što uzrokuje patološke posljedice tog stanja.
English: Chenodeoxycholic acid Leadiant is available in blister packs containing 100 hard capsules.
Croatian: Lijek Chenodeoxycholic acid Leadiant dostupan je u blister pakiranjima koja sadrže 100 tvrdih kapsula.
English: Whereas 7-keto-lithocholic acid can be formed partially in the colon and also in the liver to chenodeoxycholic acid and ursodeoxycholic acid (3α-, 7ß-di-hydroxycholanic acid), lithocholic acid is absorbed to a small extent only and is thus largely lost with faeces.
Croatian: Iako 7-ketolitokolatna kiselina može djelomično stvarati u debelom crijevu, kao i u jetri, kenodeoksikolatnu kiselinu i ursodeoksikolatnu kiselinu (3α-, 7ß-di-hidroksikolanatna kiselina), litokolatna kiselina se apsorbira samo u malim količinama i stoga uglavnom gubi fecesom.
English: Where the dose calculated is not a multiple of 250 mg, the nearest dose below the maximum of 15 mg/kg/day should be selected, provided that is sufficient to normalise serum cholestanol and/or urine bile alcohols.
Croatian: Kada izračunata doza nije višekratnik 250 mg, treba odabrati dozu koja je najbliže ispod maksimuma od 15 mg/kg/dan, pod uvjetom da je dovoljna za normaliziranje serumskog kolestanola i/ili žučnih alkohola u urinu.
English: Ciclosporin has been shown to reduce the synthesis of chenodeoxycholic acid by inhibition of CYP27A1 and increasing the activity of HMG CoA reductase.
Croatian: Pokazalo se da ciklosporin smanjuje sintezu kenodeoksikolatne kiseline tako što inhibira CYP27A1 i povećava aktivnost HMG CoA reduktaze.
English: Exogenous chenodeoxycholic acid is used as replacement therapy to restore the feedback inhibition lost due to the deficiency/absence of endogenous chenodeoxycholic acid.
Croatian: Egzogena kenodeoksikolatna kiselina koristi se kao nadomjesna terapija za obnavljanje inhibicije povratnom spregom izgubljene radi nedostatka/odsustva endogene kenodeoksikolatne kiseline.
English: • medicines to treat heartburn (antacids) containing aluminium hydroxide and/or smectite
Croatian: • lijekovi za žgaravicu (antacidi) koji sadrže aluminijev hidroksid i/ili smektit (aluminijev oksid)
English: The dose range in children is 5-15 mg/kg per day.
Croatian: Raspon doza za djecu je 5-15 mg/kg na dan.
English: No data are available for patients with hepatic impairment.
Croatian: Nema podataka o bolesnicima s oštećenjem jetre.
English: If your doctor considers it necessary for you to take ciclosporin, sirolimus or phenobarbital they will closely monitor the results of blood and urine tests and adjust the dose of Chenodeoxycholic acid Leadiant if necessary.
Croatian: Ako Vaš liječnik smatra da je neophodno da uzimate ciklosporin, sirolimus ili fenobarbital, on će pažljivo pratiti rezultate testova krvi i mokraće te će prilagoditi dozu lijeka Chenodeoxycholic acid
English: After the initiation period, cholestanol, urine bile alcohols and liver function should be determined annually, at a minimum, and the dose adjusted accordingly.
Croatian: Nakon perioda početka liječenja, kolestanol, žučne alkohole u urinu te funkciju jetre treba određivati najmanje jednom godišnje, te po potrebi prilagoditi dozu.
English: Divided dose*
Croatian: (Učestalost doze)
English: For infants and children who cannot swallow capsules, the capsules may be carefully opened and the content added to sodium bicarbonate solution 8.4%, see section 6.6.
Croatian: Za dojenčad i djecu koja ne mogu progutati kapsule, kapsule se mogu pažljivo otvoriti i sadržaj dodati 8,4%-tnoj otopini natrijevog bikarbonata, vidjeti dio 6.6.
English: Chenodeoxycholic acid is an endogenous bile acid in humans, which is tightly regulated by its secretion into bile via exporter pumps and detoxification by sulfation.
Croatian: Kenodeoksikolatna kiselina je endogena žučna kiselina kod ljudi, koja je visoko regulirana sekrecijom u žuč putem pumpi za izbacivanje i detoksifikacijom sulfatacijom.
English: Exogenous replacement with Chenodeoxycholic acid inhibits CYP7A1 (via nuclear receptor, FXR) and HMG CoA reductase, thus restoring the feedback inhibition.
Croatian: Egzogeno nadomještanje kenodeoksikolatnom kiselinom inhibira CYP7A1 (putem nuklearnog receptora, FXR) i HMG CoA reduktazu,te na taj način obnavlja inhibiciju povratnom spregom.
English: Chenodeoxycholic acid has no or negligible influence on the ability to drive and use machines.
Croatian: Kenodeoksikolatna kiselina ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: After treatment with chenodeoxycholic acid, the endogenous synthesis of the primary bile acids, cholic acid and chenodeoxycholic acid, is inhibited.
Croatian: Nakon liječenja kenodeoksikolatnom kiselinom, endogena sinteza primarnih žučnih kiselina, kolatne kiseline i kenodeoksikolatne kiseline,
English: In the supportive study CDCA-STRCH-CR-14-001 treatment of CTX patients with chenodeoxycholic acid 750 mg/day given for a median duration of 5.75 years was associated with statistically significant decreases in mean serum levels of cholestanol from baseline to any post-baseline visit.
Croatian: U potpornom ispitivanju CDCA-STRCH-CR-14-001 liječenje bolesnika s CTX-om kenodeoksikolatnom kiselinom u dozi od 750 mg/dan davanom u medijanu trajanja od 5,75 godina bilo je povezano sa statistički značajnim smanjenjem srednjih vrijednosti serumskih razina kolestanola u usporedbi između početnih vrijednosti i bilo kojeg kasnijeg posjeta.
English: In the pivotal study CDCA-STUK-15-001 treatment of CTX patients with chenodeoxycholic acid 7501000 mg/day in adults or 5-15 mg/kg/day in infants and children was associated with statistically significant decreases in mean serum levels of cholestanol from baseline to post-baseline in the overall population and in the two subgroups of patients aged < 21 years or ≥ 21 years at first treatment.
Croatian: U pivotalnom ispitivanju CDCA-STUK-15-001 liječenje bolesnika s CTX-om kenodeoksikolatnom kiselinom u dozi od 750-1000 mg/dan za odrasle ili 5-15 mg/kg/dan za dojenčad i djecu bilo je povezano sa statistički značajnim smanjenjem srednjih vrijednosti kolestanola u serumu od početnih vrijednosti do vrijednosti nakon početka liječenja u cjelokupnoj populaciji, kao i u dvije podskupine bolesnika u dobi
English: The net result is a total bile acid pool that is severely deficient in chenodeoxycholic acid but relatively enriched with cholic acid.
Croatian: Krajnji rezultat je ukupna količina žučnih kiselina u tijelu kojoj znatno nedostaje kenodeoksikolatna kiselina, ali koja je prilično obogaćena kolatnom kiselinom.
English: Deconjugation results in the free bile acid, oxidation in the 7-keto-lithocholic acid and lithocholic acid (3α-hydroxycholanic acid) is formed by elimination of the 7-hydroxy group.
Croatian: Dekonjugacijom nastaju slobodne žučne kiseline, oksidacijom 7-keto-litokolatna kiselina, a litokolatna kiselina (3α-hidroksikolanatna kiselina) stvara se eliminacijom 7-hidroksi skupine.
English: Chenodeoxycholic acid Leadiant is unlikely to cause serious side effects.
Croatian: Chenodeoxycholic acid Leadiant najvjerojatnije neće uzrokovati ozbiljne nuspojave.
English: Women should use an effective contraceptive method whilst taking Chenodeoxycholic acid Leadiant.
Croatian: Žene trebaju koristiti učinkovitu kontracepciju dok uzimaju lijek Chenodeoxycholic acid Leadiant.
English: The correct volumes should preferably be marked on the oral syringe.
Croatian: Poželjno je da na štrcaljki za usta budu naznačeni točni volumeni.
English: Co-administration of chenodeoxycholic acid with ciclosporin or sirolimus should be avoided.
Croatian: Treba izbjegavati istodobnu primjenu kenodeoksikolatne kiseline i ciklosporina ili sirolimusa.
English: Chenodeoxycholic acid Leadiant capsules treats CTX by replacing the chenodeoxycholic acid, which prevents the build-up of the fatty deposits.
Croatian: Kapsule lijeka Chenodeoxycholic acid Leadiant liječe CTX tako što nadomještaju kenodeoksikolatnu kiselinu, što sprječava nakupljanje masnih naslaga.
English: The use of oral contraceptives is not recommended in patients taking chenodeoxycholic acid, see section 4.5 for further details.
Croatian: Primjena oralnih kontraceptiva se ne preporučuje za bolesnice koje uzimaju kenodeoksikolatnu kiselinu, vidjeti dio 4.5 za dodatne informacije.
English: What you need to know before you take Chenodeoxycholic acid Leadiant Do not take Chenodeoxycholic acid Leadiant
Croatian: Što morate znati prije nego počnete uzimati Chenodeoxycholic acid Leadiant Nemojte uzimati Chenodeoxycholic acid Leadiant
English: Reduced production of cholestanol: reduces serum cholestanol (action on HMG CoA reductase and CYP7A1).
Croatian: 2. Smanjeno stvaranje kolestanola: smanjuje serumski kolestanol (djelovanje na HMG CoA reduktazu i CYP7A1).
English: The total daily dose = 10 kg x 15 mg/kg = 150 mg
Croatian: Ukupna dnevna doza = 10 kg x 15 mg/kg = 150 mg
English: Chenodeoxycholic acid should not be administered together with colestipol or antacid medicinal products containing aluminium hydroxide and/or smectite (aluminium oxide) since these preparations bind the active substance of chenodeoxycholic acid in the intestine and thus prevent its reabsorption and efficacy.
Croatian: Kenodeoksikolatna kiselina ne smije se primjenjivati zajedno s kolestipolom ili antacidima koji sadrže aluminijev hidroksid i/ili smektit (aluminijev oksid) jer ti pripravci vežu djelatnu tvar kenodeoksikolatnu kiselinu u crijevima i tako sprječavaju njezinu reapsorpciju i djelotvornost.
English: The following medicines may affect the levels of Chenodeoxycholic acid Leadiant:
Croatian: Sljedeći lijekovi mogu utjecati na razine lijeka Chenodeoxycholic acid Leadiant:
English: One instance of mild intermittent constipation occurred in an adult and another instance occurred in a child. One instance of hepatic adverse reactions occurred in a two week old infant diagnosed with CTX and is discussed in the section below.
Croatian: Jedan slučaj nuspojave vezane uz jetru se dogodio kod dva tjedna starog dojenčeta kojem je dijagnosticiran CTX i opisan je u donjem odjeljku.
English: Chenodeoxycholic acid capsules can be taken without regards to food.
Croatian: Kapsule s kenodeoksikolatnom kiselinom mogu se uzimati bez obzira na hranu.
English: (Weight in kg) x (Dose in mg/kg) = Daily dose in mg
Croatian: (Težina u kg) x (doza u mg/kg) = dnevna doza u mg podijeljena doza* (Dnevna doza u mg) = Podijeljena doza u mg
English: What you need to know before you take Chenodeoxycholic acid Leadiant 3.
Croatian: Što trebate znati prije nego počnete uzimati Chenodeoxycholic acid Leadiant 3.
English: A small portion of chenodeoxycholic acid is excreted with faeces.
Croatian: Mali dio kenodeoksikolatne kiseline se izlučuje fecesom.
English: Pharmacotherapeutic group: Alimentary tract and metabolism - Bile therapy - Bile acid preparations, ATC code: A05AA01
Croatian: - Lijekovi koji djeluju na žuč - Pripravci žučnih kiselina, ATK oznaka: A05AA01
English: Two pregnancies in mothers with CTX resulted in premature infants with evidence of intrauterine growth retardation also reported in the literature.
Croatian: U literaturi su također zabilježene dvije trudnoće kod majki s CTX-om koje su rezultirale nedonoščadi s dokazima unutarmaterničnog zastoja rasta.
English: Chenodeoxycholic acid Leadiant 250 mg hard capsules
Croatian: Chenodeoxycholic acid Leadiant 250 mg tvrde kapsule
English: It is not recommended to take oral contraceptives whilst taking Chenodeoxycholic acid Leadiant.
Croatian: Nije preporučljivo uzimati oralnu kontracepciju dok uzimate lijek Chenodeoxycholic acid Leadiant.
English: The total daily dose = 3 kg x 5 mg/kg = 15 mg
Croatian: Ukupna dnevna doza = 3 kg x 5 mg/kg = 15 mg
English: If you take more Chenodeoxycholic acid Leadiant than you should
Croatian: Ako uzmete više lijeka Chenodeoxycholic acid Leadiant nego što ste trebali
English: The divided dose when given three times a day = 15 mg = 5 mg
Croatian: Podijeljena doza kada se daje tri puta dnevno = 15 mg = 5 mg
English: Magnesium stearate Silica, colloidal anhydrous Water
Croatian: Magnezijev stearat Silicijev dioksid, koloidni bezvodni Voda
English: Read the package leaflet before use.
Croatian: Prije uporabe pročitajte uputu o lijeku Primjena kroz usta.
English: 3 kg patient on a dose of 5 mg/kg of chenodeoxycholic acid.
Croatian: bolesnik od 3 kg na dozi od 5 mg/kg kenodeoksikolatne kiseline.
English: 10 kg patient on a dose of 15 mg/kg of chenodeoxycholic acid.
Croatian: bolesnik od 10 kg na dozi od 15 mg/kg kenodeoksikolatne kiseline.
English: What Chenodeoxycholic acid Leadiant is and what it is used for 2.
Croatian: Što je Chenodeoxycholic acid Leadiant i za što se koristi 2.
English: Co-administration with oral contraceptives is not recommended, see section 4.5 for further details.
Croatian: Ne preporučuje se istodobna primjena s oralnim kontracepcijskim sredstvima, pogledajte dio 4.5 za dodatne informacije.
English: Chenodeoxycholic acid Leadiant capsules contain a substance called chenodeoxycholic acid.
Croatian: Kapsule lijeka Chenodeoxycholic acid Leadiant sadrže tvar koja se zove kenodeoksikolatna kiselina.
English: The divided dose when given three times a day = 150 mg = 50 mg
Croatian: Podijeljena doza kada se daje tri puta dnevno = 150 mg = 50mg
English: What Chenodeoxycholic acid Leadiant is and what it is used for
Croatian: Što je Chenodeoxycholic acid Leadiant i za što se koristi
English: For babies, children and those who cannot swallow capsules and/or need to take a dose below 250 mg, a capsule may be opened and the contents mixed with 8.4% sodium bicarbonate solution.
Croatian: Za bebe, djecu i one koji ne mogu progutati kapsule i/ili trebaju primiti dozu manju od 250 mg, kapsula se može otvoriti i sadržaj pomiješati s 8,4%-tnom otopinom natrijevog bikarbonata.
English: Co-administration with oral contraceptives is not recommended.
Croatian: Ne preporučuje se istodobna primjena s oralnim kontraceptivima.
English: even if their signs of illness are the same as yours.
Croatian: Može im naškoditi, čak i ako su njihovi simptomi bolesti jednaki Vašima.
English: Constipation not known
Croatian: Nuspojave vezane uz jetru nepoznato
English: Chenodeoxycholic acid should not be administered together with colestyramine as it binds chenodeoxycholic acid in the intestine and thus prevents its reabsorption and efficacy.
Croatian: Kolestiramin Kenodeoksikolatna kiselina ne smije se primjenjivati zajedno s kolestiraminom jer veže kenodeoksikolatnu kiselinu u crijevima i tako sprječava njezinu reapsorpciju i djelotvornost.
English: Chenodeoxycholic acid Leadiant capsules can be used from the age of one month and patients with CTX will require treatment for the rest of their life.
Croatian: Kapsule lijeka Chenodeoxycholic acid Leadiant mogu se koristiti od dobi od 1 mjeseca, a bolesnici s
English: Dose calculation (Infants 1month-1yr) chenodeoxycholic acid 5 mg/mL suspension Daily dose:
Croatian: Izračunavanje doze (Dojenčad 1 mjesec-1 godina) suspenzija koja sadrži 5 mg/ml kenodeoksikolatne kiseline Dnevna doza:
English: Chenodeoxycholic acid Leadiant is provided as hard capsules.
Croatian: Chenodeoxycholic acid Leadiant je u obliku tvrdih kapsula.
English: No data are available for patients with renal impairment.
Croatian: Nema podataka o bolesnicima s oštećenjem bubrega.
English: It is not known if Chenodeoxycholic acid Leadiant passes into breast milk.
Croatian: Nije poznato izlučuje li se lijek Chenodeoxycholic acid Leadiant u majčino mlijeko.
English: In order to collect long term safety and efficacy data in patients treated with Protocol - by chenodeoxycholic acid, the MAH will submit the results of a study deriving from a registry of patients with inborn errors of primary bile acid synthesis due to sterol 27 hydroxylase deficiency in infants, children and adolescents aged 1 month to 18 years and adults.
Croatian: Kako bi se prikupili podaci o dugoročnoj sigurnosti i djelotvornosti kod bolesnika liječenih kenodeoksikolatnom kiselinom, nositelj odobrenja će podnijeti rezultate ispitivanja dobivene iz registra bolesnika s urođenim greškama sinteze primarne žučne kiseline uzrokovanih nedostatkom sterol
English: D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Croatian: UVJETI I OGRANIČENJA VEZANI UZ SIGURNU I UČINKOVITU PRIMJENU
English: - The active substance is chenodeoxycholic acid.
Croatian: - Djelatna tvar je kenodeoksikolatna kiselina.
English: What Chenodeoxycholic acid Leadiant looks like and contents of the pack
Croatian: Kako izgleda Chenodeoxycholic acid Leadiant i sadržaj pakiranja
English: Chenodeoxycholic acid Leadiant 250 mg hard capsules chenodeoxycholic acid
Croatian: Chenodeoxycholic acid Leadiant 250 mg tvrde kapsule kenodeoksikolatna kiselina
English: In the intestine Chenodeoxycholic acid and its glycine or taurine conjugate are decomposed by bacteria.
Croatian: U crijevu bakterije razgrađuju kenodeoksikolatnu kiselinu i njen konjugat s glicinom ili taurinom.
English: If you have to take colestyramine then take Chenodeoxycholic acid Leadiant either one hour before colestyramine or 4-6 hours after.
Croatian: Ako trebate uzimati kolestiramin, onda uzmite lijek Chenodeoxycholic acid Leadiant ili jedan sat prije ili 4-6 sati nakon uzimanja kolestiramina.
English: If administration of ciclosporin or sirolimus is considered necessary, serum and urine bile alcohol levels should be closely monitored and the chenodeoxycholic acid dose adjusted accordingly.
Croatian: Ako se smatra da je primjena ciklosporina ili sirolimusa nužna, treba pažljivo pratiti razine žučnih alkohola u serumu i urinu, te sukladno tome prilagoditi dozu kenodeoksikolatne kiseline.
English: If administration of phenobarbital is considered necessary, serum and urine bile alcohol levels should be closely monitored and the chenodeoxycholic acid dose adjusted accordingly.
Croatian: Ako se smatra da je primjena fenobarbitala nužna, treba pažljivo pratiti razine žučnih alkohola u serumu i urinu, te sukladno tome prilagoditi dozu kenodeoksikolatne kiseline.
English: Hepatic adverse reactions not known
Croatian: Poremećaji probavnog sustava Konstipacija nepoznato