FrancophonIA/ELRC3.0 huggingface dataset:
English: Clinical efficacy in swine dysentery at a dosing regimen close to the recommended harmonised regimen of 10 mg/kg bw for 7 days is supported by older laboratory and field clinical studies, despite the fact that these are not GLP or GCP-compliant and that the clinical and bacteriological criteria for inclusion are not always precisely defined in the study reports.
Croatian: Klinička djelotvornost u svinjske dizenterije u režimu doziranja približno jednakom preporučenom usklađenom režimu od 10 mg/kg tjelesne težine tijekom 7 dana podržana je starijim laboratorijskim i terenskim kliničkim ispitivanjima, usprkos činjenici da ova ispitivanja nisu u skladu s DLP-om niti DKPom, te da klinički i bakteriološki kriteriji za uvrštavanje nisu uvijek bili precizno definirani u izvješćima ispitivanja.
English: 6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Croatian: 6.6 Posebne mjere opreza prilikom odlaganja neupotrijebljenog veterinarsko-medicinskog proizvoda ili otpadnih materijala dobivenih primjenom tih proizvoda
English: In vitro studies as well as clinical efficacy data show that the lincomycin-spectinomycin combination is active against Lawsonia intracellularis.
Croatian: In vitro pokusi, kao i podaci o kliničkoj učinkovitosti, pokazuju da je kombinacija linkomicin spektinomicin učinkovita protiv Lawsonia intracellularis.
English: For E. coli, a newly conducted pan-European MIC survey, involving 67 chicken isolates and 33 turkey isolates, showed a wide MIC range (from 2:4 to ≥256:512 µg/ml), a high spectinomycin MIC90 (256 µg/ml) and a bimodal distribution.
Croatian: U slučaju E. coli, novo provedeno paneuropsko MIC ispitivanje, koje je obuhvatilo 67 pilećih izolata i 33 puranska izolata, dokazalo je široki MIC raspon (od 2:4 do ≥256:512 µg/ml), visoke vrijednosti spektinomicina MIC90 (256 µg/ml) i bimodalnu distribuciju.
English: For those reasons, despite that the available data show no negative evolution over time, it could not be excluded that the results obtained in the old clinical studies conducted at the time of product development do not reflect clinical efficacy in modern outbreaks of swine dysentery.
Croatian: Iz navedenih razloga, usprkos činjenici da dostupni podaci ne dokazuju negativnu evoluciju tijekom vremena, ne može se isključiti da rezultati dobiveni u starim kliničkim ispitivanjima provedeni u trenutku razvoja proizvoda ne prikazuju kliničku djelotvornost u modernim izbijanjima svinjske dizenterije.
English: The indication for swine dysentery caused by Brachyspira hyodysenteriae and associated pathogens was substantiated trough a review of literature and old proprietary in vitro susceptibility data, a newly conducted B. hyodysenteriae MIC survey, and old clinical studies.
Croatian: Indikacija za svinjsku dizenteriju koju uzrokuje Brachyspira hyodysenteriae i povezanim patogenima dostavljena je potkrijepljena pregledom literature i starim vlasničkim podacima o in vitro osjetljivosti, novoprovedenim MIC ispitivanjem B. hyodysenteriae i starim kliničkim ispitivanjima.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER AND OF THE MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE, IF DIFFERENT
Croatian: NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE U PROMET I NOSITELJA ODOBRENJA ZA PROIZVODNJU ODGOVORNOG ZA PUŠTANJE SERIJE U
English: It is mainly active against Gram-positive bacteria and obligate anaerobes, and against mycoplasmas.
Croatian: Uglavnom djeluje protiv grampozitivnih bakterija i obveznih anaeroba, te protiv mikoplazmi.
English: For the preparation of drinking water, the incorporation rate of the veterinary medicinal product in water will depend on the body weight of the animals and their actual daily intake of water.
Croatian: Koncentracija VMP-a u vodi za piće ovisit će o tjelesnoj masi životinja i dnevnom unosu vode.
English: Despite the poor in vitro activity of the active substances against L. intracellularis, the combination might be effective due to combined intra- and extracellular action of lincomycin and spectinomycin, respectively.
Croatian: Usprkos slabom in vitro djelovanju aktivnih tvari kojima se suzbija L. intracellularis, kombinacija može biti djelotvorna uslijed kombiniranog unutarstaničnog i izvanstaničnog djelovanja linkomicina odnosno spektinomicina.
English: Furthermore, in addition to old experimental and field clinical efficacy studies, a recent proprietary challenge study was presented, where a total of 210 chickens were used to test efficacy of the product against induced E. coli and/or M. gallisepticum infection.
Croatian: Nadalje, uz starija eksperimentalna i terenska, klinička ispitivanja djelotvornosti, dostavljeno je novije vlasničko ispitivanje provokacije, u kojem je korišteno ukupno 210 pilića za testiranje djelotvornosti VMP-a protiv infekcija induciranih bakterijom E. coli i/ili M. gallisepticum.
English: Spectinomycin is poorly absorbed by the gastro-intestinal tract and does not easily cross membranes.
Croatian: Spektinomicin se slabo apsorbira u gastrointestinalnom traktu i ne ulazi u membrane.
English: Do not administer with kaolin or pectine as they impair lincomycin absorption.
Croatian: VMP se ne smije primjenjivati zajedno s kaolinom ili pektinom jer mogu nepovoljno utjecati na resorpciju linkomicina.
English: It inhibits protein synthesis through binding to the 50S bacterial ribosome subunit.
Croatian: Inhibira sintezu proteina tako što se vezuje na 30S ribosomsku podjedinicu.
English: Therefore, even though no evolution over time appears from the provided literature data, it cannot be excluded that the results obtained in the old clinical studies conducted at the time of product development do not reflect clinical efficacy in modern outbreaks of swine dysentery.
Croatian: Stoga, iako se čini da nije došlo do evolucije tijekom vremena na temelju podataka dostupnih iz literature, ne može se isključiti mogućnost da rezultati dobiveni u starim kliničkim ispitivanjima provedenima u trenutku razvoja proizvoda ne prikazuju kliničku djelotvornost u modernih izbijanja svinjske dizenterije.
English: Do not use in case of hypersensitivity to the active substances or any of the excipients.
Croatian: VMP se ne smije primjenjivati u slučaju preosjetljivosti na djelatne tvari ili na bilo koju pomoćnu tvar.
English: However, the most prevalent mechanism in B. hyodysenteriae and mycoplasmas is the alteration of the binding site through mutational events (chromosomal resistance).
Croatian: Međutim, najčešći mehanizam rezistencije u B. hyodysenteriae i mikoplazmi je promjena mjesta vezanja kroz zbog kromosomskih mutacija (rezistencija posredovana kromosomima).
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment) - common (more than 1 but less than 10 animals in 100 animals) - uncommon (more than 1 but less than 10 animals in 1,000 animals) - rare (more than 1 but less than 10 animals in 10,000 animals)
Croatian: Učestalost nuspojava je određena sukladno sljedećim pravilima: - vrlo česte (više od 1 na 10 životinja pokazuju nuspojavu(e) za vrijeme trajanja tretmana) - česte (više od 1 ali manje od 10 životinja na 100 životinja) - manje česte (više od 1 ali manje od 10 životinja na 1 000 životinja)
English: Lincomycin binds to the 50S sub-unit of the bacterial ribosome close to the peptidyl transfer centre and interferes with the peptide chain elongation process by inhibiting the formation of the 50S sub-unit and by stimulating ribosomal peptidyl-tRNA dissociation.
Croatian: Linkomicin se veže za podjedinicu 50S bakterijskog ribosoma u blizini centra peptidiltransferaze i sprječava produljenje peptidnih lanca, tako što sprječava tvorbu podjedinice 50S i onemogućuje vezanje peptidil-tRNK na ribosomu.
English: Volume (L) for 150 g of the veterinary medicinal product
Croatian: Volumen (L) za 150 g VMP-a =
English: Lincomycin pharmacokinetic studies in pigs show that lincomycin is bioavailable when given intravenously, intramuscularly or orally.
Croatian: Pokusi farmakokinetike linkomicina na svinjama pokazali su da je linkomicin bioraspoloživ nakon primjene u venu, mišić ili kroz usta.
English: It was the only available trial where the 50 mg/kg bw dose was firmly shown to be beneficial in a treatment context, although the challenge was rather mild (e.g. no mortality was recorded);
Croatian: dostupno ispitivanje u kojem je jasno dokazano da je doza od 50 mg/kg tjelesne težine korisna u kontekstu liječenja, iako je provokacija bila blaga (primjerice nema zabilježene smrtnosti);
English: The indication for chronic respiratory disease (CRD) associated with Mycoplasma gallisepticum and E. coli was supported by two recent MIC surveys and by older literature MIC data.
Croatian: Indikacija za kroničnu respiratornu bolest (KRB) povezana s bakterijom Mycoplasma gallisepticum i E. coli podržana je s dva novija MIC ispitivanja i starijim MIC podacima iz literature.
English: Co. Cork
Croatian: Cork
English: June http://www.who.int/foodsafety/foodborne_disease/AGISAR_2009_report_final.pdf?ua=1
Croatian: 3 Report of the first meeting of the WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR), 15-19 June 2009. http://www.who.int/foodsafety/foodborne_disease/AGISAR_2009_report_final.pdf?ua=1
English: TARGET SPECIES Pigs and chickens
Croatian: CILJNE VRSTE ŽIVOTINJA Svinja i kokoš
English: Lincomycin resistance mediated by efflux pumps, or by inactivating enzymes, has also been described.
Croatian: Također je opisana rezistencija na linkomicin posredovana pumpama za istiskivanje štetnih tvari iz stanice (efluks pumpe) ili inaktivacijskim enzimima.
English: Chickens: 16.65 mg lincomycin and 33.35 mg spectinomycin/kg bw/day, for 7 days.
Croatian: Kokoši: 16,65 mg linkomicina i 33,35 mg spektinomicina/kg tjelesne mase dnevno tijekom 7 dana.
English: 2,000 x [daily water consumption per bird (L)] average body weight of one bird (kg)
Croatian: 2 000 x [dnevni unos vode po ptici (L)]
English: Pigs: for administration via drinking water.
Croatian: Svinje: za primjenu putem vode za piće.
English: Ask your veterinary surgeon how to dispose of medicines no longer required.
Croatian: Za način odlaganja lijekova koji više nisu potrebni treba pitati veterinara.
English: This could be due to combined intra- and extracellular action of lincomycin and spectinomycin, respectively.
Croatian: Razlog tomu može biti kombinacija unutarstaničnog i izvanstaničnog djelovanja linkomicina odnosno spektinomicina.
English: Chicken
Croatian: Pilići
English: The combination was superior to lincomycin alone.
Croatian: Kombinacija je bila uspješnija od monoterapije linkomicinom.
English: SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIALS, IF ANY
Croatian: POSEBNE MJERE OPREZA PRILIKOM ODLAGANJA NEUPOTRIJEBLJENOG PROIZVODA ILI OTPADNIH MATERIJALA, AKO IH IMA
English: Likewise, information about the lack of data on the development of resistance in L. intracellularis should be included in the above mentioned sections of the SPC.
Croatian: Podjednako, u prethodno spomenute dijelove SPC-a treba uvrstiti informacije o nedostatku podataka o razvoju rezistencije u bakterije L. intracellularis.
English: The proposed withdrawal time of 0 days was well supported by a residue study where pigs were treated using the proposed harmonised dosing regimen 10 mg/kg bw/day for 7 days, and is considered acceptable by the CVMP.
Croatian: Predložena karencija u trajanju od 0 dana bila je dobro potkrijepljena ispitivanjem rezidua u slučaju kada su svinje tretirane primjenom predloženog usklađenog režima doziranja od 10 mg/kg tjelesne težine/danu tijekom 7 dana, te CVMP istu smatra prihvatljivom.
English: Strains with chromosomal resistance do not show cross-resistance with aminoglycosides.
Croatian: Sojevi čija je rezistencija na spektinomicin posredovana kromosomima ne pokazuju križnu rezistenciju na aminoglikozide.
English: Nevertheless, a clear warning as to the possibility of treatment failure due to clinically resistant strains in B. hyodysenteriae and associated Enterobacteriaceae (E. coli) should be included in section 4.4.
Croatian: Bez obzira na navedeno, u sažetak opisa svojstava VMP-a (SPC) potrebno je uvrstiti jasno upozorenje vezano uz mogućnost neuspješnog liječenja uslijed klinički rezistentnih sojeva u B. hyodysenteriae i povezane enterobakterije (E. coli) u dio 4.4.
English: Lithuania Zoetis Belgium SA Rue Laid Burniat 1
Croatian: Bugarska Zoetis Belgium SA Rue Laid Burniat 1
English: Benefit assessment
Croatian: Ocjena koristi
English: This benefit-risk evaluation is performed in the context of Article 34 of Directive 2001/82/EC, which in the present procedure has the purpose of obtaining harmonisation within the EU of the conditions of authorisation for the product Linco-Spectin 100 (and associated names).
Croatian: Direktive 2001/82/EC, koja u aktualnom postupku ima svrhu postizanja usklađivanja uvjeta odobrenja za VMP Linco-Spectin 100 (i povezane nazive) na razini EU-a.
English: Among in vitro susceptibility data for M. gallisepticum, a new MIC survey of lincomycin-spectinomycin (1:2 ratio) was carried out on 60 isolates, and showed a MIC range of [0.25:0.5 - 8:16 µg/ml], and MIC50/MIC90 values of 0.5:1 and 2:4 µg/ml, respectively.
Croatian: Uz podatke o in vitro osjetljivosti za M. gallisepticum, provedeno je novo MIC ispitivanje kombinacije linkomicina i spektinomicina (omjer 1:2) na 60 izolata, te je dokazan omjer MIC-a od [0.25:0.5 - 8:16 µg/ml], i vrijednosti MIC50/MIC90 od 0.5:1 odnosno 2:4 µg/ml.
English: Double LDPE bag containing 4.5 kg powder inside a tamper evident polypropylene tub with a polypropylene lid.
Croatian: Dvostruke vreće od LDPE s 4,5 kg praška u polipropilenskom spremniku s polipropilenskim poklopcem, koji je zapečaćen.
English: Pigs Poultry
Croatian: Svinje pilići
English: In chickens treated at several times the recommended dose, enlargement of the caecum and abnormal caecum content was observed.
Croatian: U kokoši kojima je primijenjena nekoliko puta veća doza od propisane, primijećeno je povećanje slijepog crijeva ili abnormalni sadržaj u slijepom crijevu.
English: The combination lincomycin-spectinomycin was also shown to be superior to each individual active substance.
Croatian: Kombinacija linkomicina - spektinomicina također se pokazala djelotvornijom u odnosu na svaku pojedinačnu djelatnu tvar.
English: In pigs, lincomycin is rapidly absorbed following oral administration.
Croatian: Linkomicin se u svinja vrlo brzo resorbira nakon primjene kroz usta.
English: The withdrawal time is supported by a study where chickens were treated at 500 mg/kg bw during their first week of life and at 60 mg/kg during their third week of life; depletion follow-up was conducted only after the second phase.
Croatian: Karencija je poduprijeta ispitivanjem u kojem su pilići liječeni dozom od 500 mg/kg tjelesne težine tijekom prvog tjedna života i dozom od 60 mg/kg tijekom trećeg tjedna života.
English: Use of the veterinary medicinal product deviating from the instructions in the SPC may increase the risk of development and selection of resistant bacteria and decrease the effectiveness of treatment with macrolides due to the potential for cross-resistance.
Croatian: U slučaju odstupanja od uputa za primjenu VMP-a, navedenih u Sažetku opisa svojstava, može se povećati rizik od razvoja i selekcije rezistentnih bakterija te smanjiti učinkovitost liječenja s makrolidima zbog moguće pojave križne rezistencije.
English: The proposed withdrawal time of 5 days is considered sufficient by the CVMP when chickens are treated using the proposed harmonised dosing regimen 50 mg/kg bw/day for 7 days.
Croatian: CVMP smatra ovo razdoblje dostatnim u slučaju kada se pilići liječe primjenom predloženog usklađenog režima doziranja od 50 mg/kg tjelesne težine/dana tijekom 7 dana.
English: LINCO SPECTIN 100 plv.
Croatian: LINCO SPECTIN 100 plv. sol.
English: Also, information as to widespread decreased susceptibility in B. hyodysenteriae and as to the bimodal distribution in E. coli should be added to section 5.1.
Croatian: Također, u dio 5.1. - Farmakodinamička svojstva treba dodati informacije o raširenoj smanjenoj osjetljivosti u bakterije B. hyodysenteriae i vezano uz bimodalnu distribuciju u E. coli.
English: It is known from the pharmacokinetic properties of spectinomycin that only negligible amounts are absorbed from the gut and that in any case, blood levels do not reach MIC concentrations within the respiratory tract of chickens after oral administration; in addition, spectinomycin is polar and does not readily cross membranes and distribute into the intracellular compartment.
Croatian: Na temelju farmakokinetičkih svojstava spektinomicina poznato je da su se samo zanemarive količine apsorbiraju u crijevima te da nakon peroralne primjene niti u jednom slučaju koncentracije u krvi ne dosežu koncentracije MIC-a unutar respiratornog trakta pilića.
English: Resistance to lincomycin is frequently conferred by plasmid-borne factors (erm genes) coding for methylases modifying the ribosomal binding site and frequently leading to cross-resistance to other antimicrobials of the MLSb group.
Croatian: Za rezistenciju na linkomicin često su odgovorni plazmidni čimbenici (geni erm, engl. “erythromycin resistance methylase”) za kodiranje metilaza, koje mijenjaju mjesta vezanja na ribosomu, što često dovodi do pojave križne rezistencije na antimikrobne tvari iz skupine MLSB (makrolidi, linkozamidi i streptogramin B).
English: 2 Goren E, de Jong WA, Doornenbal P. Therapeutic efficacy of medicating drinking water with spectinomycin and lincomycin-spectinomycin in experimental Escherichia coli infection in poultry.
Croatian: Therapeutic efficacy of medicating drinking water with spectinomycin and lincomycinspectinomycin in experimental Escherichia coli infection in poultry.
English: The most frequent dosing recommendation for treatment is 50 mg/kg bw/day; few SPCs recommend 150 mg/kg bw and some other ones give only a concentration in water, which corresponds approximately to 50 mg/kg bw.
Croatian: Nekoliko SPC-ova preporučilo je 150 mg/kg tjelesne težine, a pojedini drugi navode samo koncentraciju u vodi, što odgovara tjelesnoj težini od otprilike 50 mg/kg.
English: Rare cases of irritability/excitation, skin rash/pruritus were also observed.
Croatian: U manjeg broja životinja također su primijećeni razdražljivost/uzbuđenost i osip/svrbež kože.
English: Pigs and poultry (nonlayers)
Croatian: Svinje i perad (ne nesilice)
English: This amounts to 75 mg powder/kg bw/day for 7 days.
Croatian: To odgovara 75 mg praška/kg tjelesne mase dnevno tijekom 7 dana.
English: Lincomycin is a lincosamide antibiotic derived from Streptomyces lincolnensis which inhibits protein synthesis.
Croatian: Linkomicin je linkozamidni antibiotik koji se dobiva od Streptomyces lincolensis i sprječava sintezu bjelančevina.
English: The presence of the disease in the flock must be established before the product is used.
Croatian: Prisutnost bolesti u jatu mora se utvrditi prije primjene proizvoda.
English: Poultry, not eggs for human consumptio n oral
Croatian: Svinje perad, jaja nisu za ljudsku upitrebu
English: Personal protective equipment consisting of approved dust masks (either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator conforming to European Standard EN 140 with a filter EN 143), gloves and safety glasses should be worn when handling and mixing the product.
Croatian: Tijekom rada s VMP-om i njegove pripreme (miješanja) treba nositi zaštitnu opremu koja uključuje odobrene zaštitne maske protiv prašine (polumaska za jednokratnu primjenu u skladu s europskim standardom EN 149 ili maska za višekratnu primjenu u skladu s europskim standardom EN 140, s filterom EN 143), rukavice i zaštitne naočale.
English: As an indication, standard water intake varies around 0.15 L/kg bw/day.
Croatian: Standardni unos vode varira oko 0,15 L/kg tjelesne mase dnevno.
English: In a newly provided GCP challenge study the product used at 50 mg/kg bw/day for 7 days was shown to be effective in reducing clinical signs, lesions and bacteriological re-isolation associated to E. coli and/or M. gallisepticum experimental infection in chickens, although the bacterial re-isolation rate was high, with a non-statistically significant reduction for E. coli, and the MIC of the infective strains was low when compared to most field strains.
Croatian: U novo dostavljenom ispitivanju provokacije provedenom u skladu sa DKP-om, dokazano je da je proizvod korišten u dozi od 50 mg/kg tjelesne težine/danu tijekom 7 dana bio učinkovitiji u smanjivanju kliničkih znakova, lezija i bakteriologijske ponovne izolacije povezane s eksperimentalnom infekcijom E. coli i/ili M. gallisepticum u pilića, iako je stopa bakterijske ponovne izolacije bila visoka s nestatistički značajnim smanjenjem za E. coli, i MIC nedjelotvornih sojeva bio je nizak u usporedbi s većinom terenskih sojeva.
English: Do not allow rabbits, rodents (e.g. chinchillas, hamsters, guinea pigs), horses or ruminants access to water or feeds containing lincomycin.
Croatian: Kunićima, glodavcima (npr. činčilama, hrčcima, zamorčadi), konjima ili preživačima ne smije se dozvoliti pristup vodi ili hrani koja sadržava linkomicin.
English: Lincomycin resistance is widespread in B. hyodysenteriae and may lead to clinical treatment failure.
Croatian: Rezistencija na linkomicina je raširena među sojevima B. hyodysenteriae i može dovesti do neuspješnog kliničkog liječenja.
English: In a newly provided GCP-compliant challenge study the product used at 50 mg/kg/day for 7 days was shown to be effective in reducing clinical signs and lesions associated with E. coli and/or M. gallisepticum experimental infection in chickens, although the bacterial re-isolation rate was high - and its reduction was non statistically significant for E. coli - and the MIC values of the infective strains were at the very lower end of the range determined in the MIC surveys.
Croatian: U novo dostavljenom ispitivanju provokacije provedenom u skladu s DKP-om, proizvod se koristio u dozi od 50 mg/kg/danu tijekom 7 dana te se pokazao djelotvornim u smanjivanju kliničkih znakova i lezija povezanih s eksperimentalnom infekcijom bakterijom E. coli i/ili M. gallisepticum u pilića, iako je stopa bakterijskog reizolata bila vrlo visoka - i njegovo smanjenje nije bilo statistički značajno za E. coli - i MIC vrijednosti za nedjelotvorne sojeve bile su također u samom donjem području vrijednosti utvrđenih u MIC ispitivanju.
English: White HDPE bottle containing 150 g or 1.5 kg powder for oral solution with a white tamper evident LDPE lid.
Croatian: 6.5 Osobine i sastav unutarnjeg pakovanja Bijele boce od HDPE s 150 g ili 1,5 kg praška za primjenu u vodi za piće, zatvorene s bijelim poklopcem od LDPE koji je zapečaćen.
English: Tolerance is still adequately reflected by the harmonised texts for SPC sections 4.5 (i) Special precautions for use in animals, 4.6 Adverse reactions (frequency and seriousness) and 4.10 Overdose.
Croatian: Posebne mjere opreza za primjenu u životinja, 4.6 Nuspojave (učestalost i ozbiljnost) i 4.10 Prekomjerna doza.
English: In chickens, in order to reflect the fact that in the only study formally demonstrating efficacy of the 50 mg/kg dose against CRD clinical signs and lesions, the challenge was mild to moderate with no mortality recorded, it is proposed to amend the indication as follows:
Croatian: U slučaju pilića, kako bi se prikazala činjenica da je samo u jednom ispitivanju formalno prikazana djelotvornost doze od 50 mg/kg protiv kliničkih znakova KRB-a i lezija, provokacija je bila blaga do umjerena bez prijavljene smrtnosti.
English: MANUFACTURER'S BATCH NUMBER Lot:
Croatian: 17. BROJ PROIZVODNE SERIJE PROIZVOĐAČA
English: Poultry (broilers)
Croatian: Pilići (brojleri)
English: Resistance to lincomycin can develop in B. hyodysenteriae and most of the isolates studied show decreased susceptibility in vitro.
Croatian: Rezistencija B. hyodysenteriae na linkomicin može se brzo razviti i većina ispitivanih izolata je pokazala smanjenu osjetljivost in vitro.