FrancophonIA/ELRC3.0 huggingface dataset:
English: The safety of dabrafenib in combination with trametinib has been evaluated in the integrated safety population of 1076 patients with BRAF V600 mutant unresectable or metastatic melanoma, Stage III BRAF V600 mutant melanoma following complete resection (adjuvant treatment) and advanced NSCLC treated with dabrafenib 150 mg twice daily and trametinib 2 mg once daily.
Danish: Sikkerheden af dabrafenib i kombination med trametinib er blevet evalueret i den integrerede sikkerhedspopulation på 1076 patienter med BRAF V600-muteret, inoperabelt eller metastatisk melanom, stadie III BRAF V600-muteret melanom efter komplet resektion (adjuverende behandling) og fremskreden NSCLC, der blev behandlet med dabrafenib 150 mg to gange dagligt og 2 mg trametinib en gang dagligt.
English: Serious skin reactions have been reported in people taking Tafinlar in combination with trametinib.
Danish: Der er rapporteret tilfælde af alvorlige hudreaktioner hos personer, der tog Tafinlar i kombination med trametinib.
English: • some anti-inflammatory medicines, such as dexamethasone and methylprednisolone
Danish: • visse antiinflammatoriske lægemidler, fx dexamethason og methylprednisolon
English: Improvements for the secondary endpoint of PFS were sustained over a 5 year timeframe in the combination arm compared to vemurafenib monotherapy.
Danish: Forbedringeri det sekundære endepunkt PFS blev opretholdt i en tidsramme på 5 år i kombinationsarmen, sammenlignet med vemurafenib monoterapi.
English: separation of the light-sensitive membrane in the back of the eye (the retina) from its supporting layers (retinal detachment) and swelling around the eyes
Danish: løsning af den lysfølsomme membran bagerst i øjet (nethinden) fra dens understøttende lag
English: Patients should be evaluated for signs and symptoms of infection (see section 4.4).
Danish: Patienterne bør vurderes for tegn og symptomer på infektion (se pkt.
English: • Corticosteroids (e.g. dexamethasone, methylprednisolone)
Danish: • Kortikosteroider (fx dexamethason, methylprednisolon)
English: There are insufficient data to evaluate the potential effect of other races on dabrafenib pharmacokinetics.
Danish: Der er ikke tilstrækkelige data til at vurdere, i hvilken udstrækning dabrafenibs farmakokinetik bliver påvirket af andre racer.
English: The efficacy and safety of dabrafenib have not been established in patients with wild-type BRAF melanoma or wild-type BRAF NSCLC.
Danish: Dabrafenibs virkning og sikkerhed er ikke klarlagt hos patienter med vildtype BRAF-melanom eller vildtype BRAF-NSCLC.
English: Elevations in blood pressure have been reported in association with dabrafenib in combination with trametinib, in patients with or without pre-existing hypertension.
Danish: Der er set blodtryksstigning i forbindelse med behandling med dabrafenib i kombination med trametinib, hos patienter med eller uden allerede eksisterende hypertension.
English: In the Phase III study BRF115532 in the adjuvant treatment of melanoma, the incidence and severity of pyrexia were higher in the dabrafenib in combination with trametinib arm (67%; 6% Grade 3/4) as compared to the placebo arm (15%; <1% Grade 3).
Danish: I fase III-studiet BRF115532 med den adjuverende behandling af melanom, var forekomsten og sværhedsgraden af feber højere i armen med dabrafenib i kombination med trametinib (67 %; 6 % grad 3/4) sammenlignet med placebo-armen (15 %; < 1 % grad 3).
English: • have or have had any gastrointestinal problems such as diverticulitis (inflamed pouches in the colon) or metastases to the gastrointestinal tract.
Danish: • om du har eller har haft problemer med mave eller tarm, som fx diverticulitis (betændte udposninger i tyktarmen) eller metastaser i mave-tarmkanalen.
English: Ask your doctor, pharmacist or nurse for advice.
Danish: Spørg lægen, apotekspersonalet eller sundhedspersonalet til råds.
English: How should you take Tafinlar in combination with trametinib
Danish: Sådan skal du tage Tafinlar i kombination med trametinib
English: Of the total number of patients in the integrated safety population of dabrafenib monotherapy (n=578), 22% were 65 years of age and older, and 6% were 75 years of age and older.
Danish: Af det samlede antal patienter i den integrerede sikkerhedspopulation med dabrafenib-monoterapi (n = 578) var 22 % ≥ 65 år og 6 % ≥ 75 år.
English: In patients with BRAF V600K mutation positive metastatic melanoma (n=16) the response rate was 13% (95% CI: 0.0, 28.7) with a median DoR of 5.3 months (95% CI: 3.7, 6.8).
Danish: Hos patienterne med metastatisk BRAF V600K-mutationspositivt melanom (n = 16) var responsraten 13 % (95 % CI: 0,0; 28,7) med en median DoR på 5,3 måneder (95 % CI: 3,7; 6,8).
English: Dehydration Hyponatraemia Hypophosphataemia Hyperglycaemia
Danish: Dehydrering Hyponatriæmi Hypofosfatæmi Hyperglykæmi
English: • coughing up of blood or blood clots
Danish: • ophostning af blod eller blodklumper
English: There are no data in humans for dabrafenib as monotherapy or in combination with trametinib.
Danish: Der er ingen data om mennesker for dabrafenib som monoterapi eller i kombination med trametinib.
English: Table 14 Investigator-assessed RFS results for Study BRF115532 (COMBI-AD)
Danish: Tabel 14 Investigator-vurderede RFS-resultater for studie BRF115532 (COMBI-AD)
English: The recommended dose of dabrafenib, either used as monotherapy or in combination with trametinib, is 150 mg (two 75 mg capsules) twice daily (corresponding to a total daily dose of 300 mg).
Danish: Den anbefalede dosis af dabrafenib, enten som monoterapi eller i kombination med trametinib, er 150 mg (to 75 mg kapsler) to gange dagligt (svarende til en samlet daglig dosis på 300 mg).
English: • Calcium channel blockers (e.g. diltiazem, felodipine, nicardipine, nifedipine, verapamil)
Danish: • Calciumantagonister (fx diltiazem, felodipin, nicardipin, nifedipin, verapamil)
English: • passing blood in the stools or passing black stools
Danish: • blod i afføringen eller sort afføring
English: • Skin effects including cutaneous squamous cell carcinoma (a type of skin cancer), wart-like growths, skin tags, uncontrolled skin growths or lesions (basal cell carcinoma), dry skin, itching or redness of skin, patches of thick, scaly, or crusty skin (actinic keratosis), skin lesions, skin reddening, increased sensitivity of the skin to sun
Danish: • hudreaktioner, herunder kutant pladecellekarcinom (en form for hudkræft), vortelignende vækster, stilkevorter (skin tags), ukontrolleret hudvækst eller mindre forandringer i huden (basal cellekarcinom), tør hud, kløe eller rød hud, tykke, skællede eller skorpede pletter på huden
English: Dabrafenib was not mutagenic or clastogenic using in vitro tests in bacteria and cultured mammalian cells, and an in vivo rodent micronucleus assay.
Danish: Dabrafenib var ikke mutagent eller klastogent i test udført in vitro på bakterier og dyrkede pattedyrsceller og i en mikronukleusanalyse udført in vivo hos gnavere.
English: If creatinine increases, dabrafenib may need to be interrupted as clinically appropriate.
Danish: Hvis serum-kreatinin stiger, kan det være nødvendigt at pausere dabrafenib efter klinisk behov.
English: The investigator assessed confirmed response rate in patients with BRAF V600E metastatic melanoma (n=76) was 59% (95% CI: 48.2, 70.3) and the median DoR was 5.2 months (95% CI: 3.9, not calculable) based on a median follow-up time of 6.5 months.
Danish: Den af investigator vurderede bekræftede responsrate hos patienterne med metastatisk BRAF V600E-mutationspositivt melanom (n = 76) var 59 % (95 % CI: 48,2; 70,3), og den mediane DoR var 5,2 måneder (95 % CI: 3,9; kunne ikke beregnes) baseret på en median opfølgningstid på 6,5 måneder.
English: You will be checked for any heart problems while you are taking Tafinlar in combination with trametinib.
Danish: Det vil løbende blive kontrolleret, om du har hjerteproblemer, mens du tager Tafinlar i kombination med trametinib.
English: 3.7 (1.6, 5.2) 5.0 (3.5, NR) Abbreviations: CI: confidence interval; NR: not reached; NA: not applicable a Confirmed response.
Danish: Forkortelser: CI: konfidensinterval; NR: ikke nået; NA: ikke relevant a Bekræftet respons.
English: • Inflammation of the fatty layer under the skin (panniculitis)
Danish: • betændelse i fedtlaget under huden (panniculitis)
English: The 5-year overall survival rate was 40% (95% CI: 31.2, 48.4) in the combination arm versus 33% (95% CI: 25.0, 41.0) in the dabrafenib monotherapy arm for patients who had a normal lactate dehydrogenase level at baseline, and 16% (95% CI: 8.4, 26.0) in the combination arm versus 14% (95% CI: 6.8, 23.1) in the dabrafenib monotherapy arm for patients with an elevated lactate dehydrogenase level at baseline.
Danish: 5 års samlet overlevelsesrate var 40% (95% CI: 31,2; 48,4) i kombinationsarmen versus 33% (95% CI: 25,0; 41,0) i dabrafenib monoterapiarmen, for patienter der havde normal laktatdehydrogenaseniveau ved baseline, og 16% (95% CI: 8,4; 26,0) i kombinationsarmen versus 14% (95% CI: 6,8; 23,1) i dabrafenib monoterapiarmen, for patienter med forhøjet laktatdehydrogenaseniveau ved baseline.
English: In vitro, dabrafenib is a mechanism based inhibitor of CYP3A4.
Danish: In vitro er dabrafenib en mekanismebaseret hæmmer af CYP3A4.
English: For patients with unresectable or metastatic melanoma who received dabrafenib in combination with trametinib and developed pyrexia, approximately half of the first occurrences of pyrexia happened within the first month of therapy and approximately one-third of the patients had 3 or more events.
Danish: For patienter med inoperabelt eller metastatisk melanom, der fik dabrafenib i kombination med trametinib, og som udviklede feber, opstod ca. halvdelen af febertilfældene inden for den første behandlingsmåned, og ca. 1/3 af patienterne havde 3 eller flere tilfælde.
English: The majority of subjects had a BRAF V600E mutation (85%).
Danish: Størstedelen af forsøgsdeltagerne havde BRAF V600E-mutation (85 %).
English: • birth control medicines (contraceptives) containing hormones, such as pills, injections, or patches
Danish: • svangerskabsforebyggende lægemidler (kontraceptiva), der indeholder hormoner, fx piller,
English: In the Phase III study MEK116513 four patients (1%) treated with trametinib in combination with dabrafenib had a QTcB Grade 3 increase (>500 msec).
Danish: I fase III-studiet MEK 116513 havde 4 patienter (1 %), som blev behandlet med trametinib i kombination med dabrafenib, QTcB grad 3-forlængelse (> 500 ms).
English: In the Phase II study BRF113928 in patients with advanced NSCLC the incidence and severity of pyrexia were increased slightly when dabrafenib was used in combination with trametinib (48%, 3% Grade 3) as compared to dabrafenib monotherapy (39%, 2% Grade 3).
Danish: I fase II-studiet BRF113928 med patienter med fremskreden NSCLC var forekomsten og sværhedsgraden af feber en smule højere, når dabrafenib blev anvendt i kombination med trametinib (48 %, heraf grad 3 hos 3 %) sammenlignet med dabrafenib-monoterapi (39 %, heraf grad 3 hos 2 %).
English: In the Phase III clinical trials MEK115306 and MEK116513 in patients with unresectable or metastatic melanoma, cuSCC occurred in 10% (22/211) of patients receiving dabrafenib as a monotherapy and in 18% (63/349) of patients receiving vemurafenib as a monotherapy, respectively.
Danish: I de kliniske fase III-forsøg MEK115306 og MEK116513 med patienter med inoperabelt eller metastatisk melanom forekom cuSCC hos 10 % (22/211) af de patienter, der fik dabrafenib som monoterapi, og hos 18 % (63/349) af de patienter, der fik vemurafenib som monoterapi.
English: As hepatic metabolism and biliary secretion are the primary routes of elimination of dabrafenib and its metabolites, administration of dabrafenib should be undertaken with caution in patients with moderate to severe hepatic impairment (see section 4.2).
Danish: Da dabrafenib og dets metabolitter primært elimineres via hepatisk metabolisering og biliær udskillelse, bør dabrafenib administreres med forsigtighed hos patienter med moderat til svært nedsat leverfunktion (se pkt.
English: • Dabrafenib monotherapy
Danish: • Dabrafenib-monoterapi
English: The most common adverse reactions (incidence 15%) reported with dabrafenib were hyperkeratosis, headache, pyrexia, arthralgia, fatigue, nausea, papilloma, alopecia, rash, and vomiting.
Danish: De hyppigste bivirkninger (forekomst  15 %) rapporteret ved dabrafenib var hyperkeratose, hovedpine, pyreksi, artralgi, træthed, kvalme, papillom, alopeci, udslæt og opkastning.
English: Trametinib is not recommended if you have ever had blockage of the vein draining the eye (retinal vein occlusion).
Danish: Trametinib anbefales ikke, hvis du har haft blokade af den vene, som leder væske fra øjet (retinal veneokklusion).
English: Dose adjustment for trametinib below 1 mg once daily is not recommended, when used in combination with dabrafenib.
Danish: Justering af trametinibdosis til en dosis lavere end 1 mg en gange dagligt anbefales ikke, når det anvendes i kombination med dabrafenib.
English: Do not stop unless your doctor, pharmacist or nurse advises you to.
Danish: Hold ikke op med at tage Tafinlar, medmindre lægen, apotekspersonalet eller sundhedspersonalet råder dig til at stoppe.
English: New malignancies
Danish: Nye maligniteter
English: New primary melanomas have been reported in clinical trials in patients treated with dabrafenib.
Danish: I kliniske studier er der rapporteret nye primære melanomer hos patienter, behandlet med dabrafenib.
English: Cutaneous squamous cell carcinoma Seborrhoeic keratosis Acrochordon (skin tags) Basal cell carcinoma
Danish: Kutant planocellulært karcinom Seborroisk keratose Akrokordon (skin tags) Basal celle karcinom
English: Eye problems
Danish: Øjenproblemer
English: The combination of dabrafenib with trametinib has shown anti-tumour activity in BRAF V600 mutation positive melanoma cell lines in vitro and delays the emergence of resistance in vivo in BRAF V600 mutation positive melanoma xenografts.
Danish: Kombinationen af dabrafenib og trametinib har vist anti-tumoraktivitet i BRAF V600-mutationspositive melanomcellelinjer in vitro og forsinket resistensudvikling i xenografter med BRAF V600-mutationspositive melanomer in vivo.
English: In the Phase III study MEK115306 no patients treated with trametinib in combination with dabrafenib had worst-case QTcB prolongation to >500 msec; QTcB was increased more than 60 msec from baseline in 1% (3/209) of patients.
Danish: Ingen patienter, som blev behandlet med trametinib i kombination med dabrafenib, i fase III-studiet MEK115306 havde alvorlig QTcB-forlængelse til > 500 ms. QTcB blev forlænget med mere end 60 ms i forhold til baseline hos 1 % (3/209) af patienterne.
English: palpitations and chest pain
Danish: hjertebanken og brystsmerter
English: Hypophosphataemia has been reported commonly in the integrated safety population of dabrafenib monotherapy (7%) and of dabrafenib in combination with trametinib (4%).
Danish: Hypofosfatæmi er almindeligt forekommende i den integrerede sikkerhedspopulation med dabrafenib som monoterapi (7 %) og med dabrafenib i kombination med trametinib (4 %).
English: The efficacy of dabrafenib in the treatment of adult patients with BRAF V600 mutation positive unresectable or metastatic melanoma has been evaluated in 3 clinical trials (BRF113683 [BREAK-3], BRF113929 [BREAK-MB], and BRF113710 [BREAK-2]) including patients with BRAF V600E and/or V600K mutations.
Danish: Effekten af dabrafenib i behandlingen af voksne patienter med inoperabelt eller metastatisk BRAF V600-mutationspositivt melanom er blevet vurderet i 3 kliniske forsøg (BRF113683 [BREAK-3], BRF113929 [BREAK-MB] og BRF113710 [BREAK-2]), som omfattede patienter med BRAF V600E- og/eller V600K-mutationer.
English: • Thickening of the outer layer of the skin (hyperkeratosis), patches of thick, scaly, or crusty skin
Danish: • fortykkelse af det ydre hudlag (hyperkeratose), tykke, skællede eller skorpede pletter på huden
English: • Eye changes including swelling in the eye caused by fluid leakage (chorioretinopathy),
Danish: • øjenforandringer, herunder hævelse i øjet forårsaget af udsivning af væske (korioretinopati),
English: Dabrafenib in combination with trametinib is indicated for the adjuvant treatment of adult patients with Stage III melanoma with a BRAF V600 mutation, following complete resection.
Danish: Dabrafenib i kombination med trametinib er indiceret til adjuverende behandling af voksne patienter med stadie III melanom med en BRAF V600-mutation efter komplet resektion.
English: • Anticoagulants (e.g. acenocoumarol, warfarin, see section 4.4)
Danish: • Antikoagulantia (fx acenocoumarol, warfarin, se pkt.
English: Dabrafenib in combination with trametinib is indicated for the treatment of adult patients with advanced non-small cell lung cancer with a BRAF V600 mutation.
Danish: Dabrafenib i kombination med trametinib er indiceret til behandling af voksne patienter med fremskreden ikke-småcellet lungecancer med BRAF V600-mutation.
English: • Cohort A: Monotherapy (dabrafenib 150 mg twice daily), 84 patients enrolled.
Danish: • Kohorte A: Monoterapi (dabrafenib 150 mg to gange dagligt), 84 patienter inkluderet.
English: Cutaneous squamous cell carcinoma (cuSCC)
Danish: Kutant planocellulært karcinom (cuSCC)
English: From an OS analysis at 5 years, the median OS for the combination arm was approximately 7 months longer than for dabrafenib monotherapy (25.8 months versus 18.7 months) with 5-year survival rates of 32% for the combination versus 27% for dabrafenib monotherapy (Table 6, Figure 1).
Danish: Fra en analyse af OS ved 5 år var median OS i kombinationsarmen ca. 7 måneder længere end for dabrafenib monoterapi (25,8 måneder vs. 18,7 måneder) med 5-års overlevelsesrater på 32% for kombinationen, versus 27% for dabrafenib monoterapi (tabel 6, figur 1).
English: For patients who received dabrafenib in combination with trametinib and developed pyrexia, approximately half of the first occurrences of pyrexia happened within the first month of therapy and approximately one-third of the patients had 3 or more events.
Danish: For patienter, som fik dabrafenib i kombination med trametinib, og som udviklede feber, opstod ca. halvdelen af febertilfældene inden for den første behandlingsmåned, og ca. 1/3 af patienterne havde 3 eller flere tilfælde.
English: Cohort B N=65
Danish: Kohorte B N = 65
English: Table 2 Dose modification schedule based on the grade of any adverse events (AE)
Danish: Tabel 2: Dosisjusteringsskema baseret på graden af bivirkningen
English: 2nd dose reduction
Danish: 2. dosisreduktion
English: How to take Tafinlar
Danish: Sådan skal du tage Tafinlar
English: From an OS analysis at 5 years, the median OS for the combination arm was approximately 8 months longer than the median OS for vemurafenib monotherapy (26.0 months versus 17.8 months) with 5-year survival rates of 36% for the combination versus 23% for vemurafenib monotherapy (Table 8, Figure 2).
Danish: Fra en analyse af OS ved 5 år var median OS i kombinationsarmen ca. 8 måneder længere end for vemurafenib monoterapi (26,0 måneder vs. 17,8 måneder) med 5-års overlevelsesrater på 36% for kombinationen, versus 23% for vemurafenib monoterapi (tabel 8, figur 2).
English: New primary melanomas have been reported in clinical trials with dabrafenib as monotherapy and in combination with trametinib in melanoma studies.
Danish: Der er rapporteret nye primære melanomer i kliniske studier med dabrafenib som monoterapi og i kombination med trametinib i melanomstudier.
English: Permanently discontinue trametinib and dabrafenib for life-threatening pulmonary embolism.
Danish: Trametinib og dabrafenib skal seponeres permanent ved livstruende lungeemboli.
English: Do not make up for missed doses and just take your next dose at your regular time: o If it is less than 6 hours to your next scheduled dose of Tafinlar, which is taken twice daily.
Danish: • Hvis du glemmer at tage en dosis af Tafinlar eller trametinib, skal du tage den, så snart du kommer i tanke om det. Erstat ikke glemte doser, og tag blot din næste dosis på det sædvanlige tidspunkt: o Hvis der er mindre end 6 timer til din næste planlagte dosis af Tafinlar, som tages to gange dagligt.
English: No clinically relevant effect of dabrafenib or its metabolites on the QTc interval was observed.
Danish: Der blev ikke observeret nogen klinisk relevant indvirkning på QT-intervallet af dabrafenib eller dets metabolitter.
English: Tafinlar 75 mg hard capsules are opaque dark pink and imprinted with “GS LHF” and “75 mg”.
Danish: Tafinlar 75 mg hårde kapsler er uigennemsigtige, mørk pink og påtrykt ”GS LHF” og ”75 mg”.
English: Cohort A N=15
Danish: Kohorte A N = 15
English: In these patients a 13% (95 CI: 5.0, 27.0) confirmed response rate was observed with a median PFS of 3.6 months (95% CI: 2, 4).
Danish: Hos disse patienter blev der observeret en bekræftet responsrate på 13 % (95 % CI: 5,0; 27,0) med en median PFS på 3,6 måneder (95 % CI: 2; 4).
English: No dose modifications are required as long as effective local therapies can control ocular inflammation.
Danish: Det er ikke nødvendigt at justere dosis ved uveitis, så længe effektiv lokalbehandling kan kontrollere den okulære inflammation.
English: Combination with trametinib
Danish: Kombination med trametinib
English: Nausea Vomiting Diarrhoea
Danish: Kvalme Opkastning Diarré
English: In the combination therapy arm of study MEK115306 in patients with unresectable or metastatic melanoma, pyrexia was reported in 57% (119/209) of patients with 7% Grade 3, as compared to the dabrafenib monotherapy arm with 33% (69/211) of patients reporting pyrexia, 2% Grade 3.
Danish: I kombinationsbehandlings-armen i MEK115306-studiet med patienter med inoperabelt eller metastatisk melanom blev feber rapporteret hos 57 % (119/209) af patienterne, heraf grad 3 hos 7 %, sammenlignet med dabrafenib-monoterapiarmen, hvor 33 % (69/211) af patienterne rapporterede feber, heraf grad 3 hos 2 %.
English: Previously untreated patients (results from the Phase III study [BREAK-3]) The efficacy and safety of dabrafenib were evaluated in a Phase III randomised, open-label study [BREAK 3] comparing dabrafenib to dacarbazine (DTIC) in previously untreated patients with BRAF V600E mutation positive advanced (unresectable Stage III) or metastatic (Stage IV) melanoma.
Danish: Tidligere ubehandlede patienter (resultater fra fase III-studiet [BREAK-3]) Effekten og sikkerheden af dabrafenib blev undersøgt i et randomiseret, ublindet fase III-studie (BREAK-3), hvor dabrafenib blev sammenlignet med dacarbazin (DTIC) hos tidligere ubehandlede patienter med fremskredent (inoperabelt, stadium III) eller metastatisk (stadium IV) BRAF V600E-mutationspositivt melanom.
English: In vitro, dabrafenib produced dose-dependent increases in CYP2B6 and CYP3A4.
Danish: In vitro medførte dabrafenib dosisafhængige stigninger i CYP2B6- og CYP3A4-niveauet.
English: New malignancies, cutaneous and non-cutaneous, can occur when dabrafenib is used as monotherapy or in combination with trametinib.
Danish: Der kan opstå nye maligniteter, kutane og ikke-kutane, når dabrafenib anvendes som monoterapi eller i kombination med trametinib.
English: Carcinogenicity studies with dabrafenib have not been conducted.
Danish: Der er ikke udført studier, hvor karcinogeniciteten af dabrafenib er blevet undersøgt.
English: • Kidney problems, kidney failure
Danish: • nyreproblemer, nyresvigt
English: The majority of subjects had BRAF V600E mutation-positive melanoma (89%).
Danish: Størstedelen af forsøgsdeltagerne havde BRAF V600E-mutationspositivt melanom (89 %).
English: Opaque white high density polyethylene (HDPE) bottle with polypropylene screw cap and a silica gel desiccant.
Danish: Uigennemsigtig hvid beholder af højdensitetspolyethylen (HDPE) med polypropylenlåg og et tørremiddel bestående af silicagel.
English: Effects of dabrafenib on substance transport systems
Danish: Dabrafenibs indvirkning på stoftransportsystemer
English: Your doctor may take blood samples to monitor your liver and kidney function while you are taking Tafinlar.
Danish: Lægen vil tage blodprøver for at måle din lever- og nyrefunktion, mens du er i behandling med