FrancophonIA/ELRC3.0 huggingface dataset:
English: Suspend treatment until Grade 0 or 1 Reduce by 1 dose level from previous level Second occurrence Suspend treatment until Grade 0 or 1 Reduce by 1 dose level from previous level
Danish: Indstil behandlingen indtil grad 0 eller 1 Reducer med 1 dosisniveau i forhold til foregående niveau
English: 4.6 Fertility, pregnancy and lactation
Danish: 4.6 Fertilitet, graviditet og amning/kontraception hos mænd og kvinder Kvinder i den fertile alder
English: - Nerve disorder: you may feel numbness, tingling, pain, abnormal sensation, weak muscle, shaking, or movement difficulties.
Danish: - Nervelidelser: du kan få følelsesløshed, prikken, smerter, unormale fornemmelser, svage muskler, rystelser eller besvær med at bevæge dig.
English: Dose reduction 1 (mg/m2)
Danish: Dosisreduktion 1 (mg/m2)
English: No data are available on the effect of Teysuno in combination with cisplatin on human fertility.
Danish: Der foreligger ingen data om virkningen af Teysuno i kombination med cisplatin på human fertilitet.
English: Toxic epidermal necrolysis, Stevens-Johnson syndrome, photosensitivity reaction, nail disorder
Danish: Toksisk epidermal nekrolyse, StevensJohnsons syndrom, lysfølsomhedsre aktion, neglesygdom
English: The median Tmax for 5-FU was 2.0 hours and the mean AUC0-inf and Cmax was 842 ± 252 ng.hr/ml and 174 ± 58 ng/ml.
Danish: Den gennemsnitlige Tmaks for 5-FU var 2,0 timer, og den gennemsnitlige AUC0-inf og Cmaks var 842 ± 252 ng.t/ml og 174 ± 58 ng/ml.
English: In case you are using blood thinning or anti-seizure medicines, stopping Teysuno might require that your doctor adjusts the dose of your medicines.
Danish: Hvis du får blodfortyndende medicin eller anfaldsmedicin, skal lægen eventuelt justere dosis af lægemidlerne, når du stopper med at tage Teysuno.
English: No adjustment of the standard dose is recommended in patients >70 years old (see section 4.8).
Danish: Der anbefales ingen justering af den sædvanlige dosis hos patienter >70 år (se pkt.
English: Diarrhoea, vomiting, nausea, constipation
Danish: Diarré, opkastning, kvalme, obstipation
English: • Vision disorder includes adverse reactions of blurred vision, diplopia, photopsia, reduced visual acuity, and blindness;
Danish: • Synsforstyrrelser omfatter bivirkninger i form af tågesyn, diplopi, fotopsi, nedsat visuel akuitet og blindhed
English: Suspend cisplatin treatment until resumption criterion (≥30 ml/min) is met and then start treatment at a 50% dose reduction from the previous cycle a Treatment for patients with CrCl <30 ml/min is not recommended unless the benefits of Teysuno treatment clearly outweigh the risks.
Danish: er opfyldt og genindled dernæst behandlingen ved en 50 % lavere dosis end det foregående behandlingsforløb a Behandling af patienter med CrCl <30 ml/min anbefales ikke, medmindre fordelene ved Teysunobehandlingen klart opvejer risiciene.
English: Mean 5-FU maximum plasma concentration (Cmax) and area under the concentration-time curve (AUC) values were approximately 3-fold higher after Teysuno administration than after administration of tegafur alone, despite a 16-fold lower Teysuno dose (50 mg of tegafur) compared to tegafur alone (800 mg), and are attributed to inhibition of DPD by gimeracil.
Danish: Den gennemsnitlige maksimale plasmakoncentration (Cmaks) af 5-FU og arealet under koncentration/tid-kurven (AUC) var ca. 3 gange højere efter indgift af Teysuno end efter indgift af tegafur alene, på trods af en 16 gange lavere Teysuno-dosis (50 mg tegafur) i sammenligning med tegafur alene (800 mg), hvilket tilskrives gimeracils hæmning af DPD.
English: • Hypersensitivity to any of the active substances (tegafur, gimeracil, and oteracil) or to any of the excipients listed in section 6.1.
Danish: • Overfølsomhed over for et eller flere af de aktive stoffer (tegafur, gimeracil og oteracil) eller over for et eller flere af hjælpestofferne anført i pkt.
English: Other oral fluorpyrimidines
Danish: Andre orale fluoropyrimidiner
English: However, metabolites of folinate/folinic acid will form a ternary structure with thymidylate synthase and fluorodeoxyuridine monophosphate (FdUMP), potentially increasing the cytotoxicity of 5-FU.
Danish: Metabolitter af folinat/folinsyre stabiliserer et tertiært kompleks med thymidylatsyntase og fluorodeoxyuridinmonofosfat (FdUMP), hvilket potentielt kan øge cytotoksiciteten i 5-FU.
English: You should check with your doctor if you are not sure.
Danish: Tal med lægen, hvis der er noget, du er i tvivl om.
English: Adverse reactions of Grade 3 or higher such as increased blood creatinine, decreased creatinine clearance, toxic nephropathy, and acute renal failure have all been reported in patients receiving Teysuno in combination with cisplatin (see section 4.8).
Danish: grad 3 eller værre, såsom forhøjet creatinin i blodet, nedsat creatinin-clearance, toksisk nefropati og akut nyresvigt er alle rapporteret hos patienter i behandling med Teysuno i kombination med cisplatin (se pkt.
English: Each pack contains either 42 capsules, 84 capsules or 126 capsules.
Danish: Hver pakning indeholder enten 42 kapsler, 84 kapsler eller 126 kapsler.
English: Teysuno dose modification at the start of the cycle of treatment
Danish: Dosisændring af Teysuno ved starten på et behandlingsforløb
English: Dose reduction 2 (mg/m2)
Danish: Dosisreduktion 2 (mg/m2)
English: Patients receiving oral coumarin-derivative anticoagulant therapy must have their anticoagulant response (International Normalized Ratio for prothrombin time [INR] or prothrombin time [PT]) monitored closely and the anticoagulant dose adjusted accordingly (see section 4.5).
Danish: Patienter, som er i behandling med peroral antikoagulant behandling med coumarin (eller coumarinderivat), skal have effekten af antikoagulantbehandlingen (INR-værdi [International Normalized Ratio] for protrombintid [PT]) nøje kontrolleret og antikoagulantdosis justeret tilsvarende (se pkt.
English: Therefore, brivudine must not be administered concomitantly with Teysuno (see section 4.3 and 4.4).
Danish: Brivudin må derfor ikke administreres samtidig med Teysuno (se pkt.
English: Teysuno should only be given on Days 1 to 21 of each cycle, i.e., treatment should not be given on Days 22 to 28 of a cycle.
Danish: Teysuno bør kun gives på dag 1 til 21 i hvert behandlingsforløb.
English: Dehydration, hypokalaemia, hyponatraemia, hypocalcaemia, hypomagnesaemia, hypoalbuminaemia, hyperkalaemia
Danish: Dehydrering, hypokaliæmi, hyponatriæmi, hypocalcæmi, hypomagnesiæmi hypoalbuminæmi , hyperkaliæmi
English: MARKETING AUTHORISATION NUMBER(S) EU/1/11/669/001
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (NUMRE) EU/1/11/669/001
English: Table 5: Haematologic toxicities for which Teysuno treatment should be suspended Units
Danish: Tabel 5: Hæmatologiske toksiciteter ved hvilke Teysuno-behandlingen skal pauseres Enheder Neutrofile Trombocytt er
English: No pharmacokinetc studies have been conducted with Teysuno in paediatric patients.
Danish: Der er ikke udført farmakokinetiske forsøg med Teysuno hos børn.
English: Nonclinical studies demonstrated that Teysuno did not appear to affect male or female fertility in the rat (see section 5.3).
Danish: Prækliniske forsøg har påvist, at Teysuno ikke lader til at påvirke fertiliteten hos han- og hunrotter (se pkt.
English: No adjustment of the standard dose is recommended for patients of Asian ethnicity (see section 5.2).
Danish: Der anbefales ingen justering af den sædvanlige dosis hos patienter af asiatisk oprindelse (se pkt.
English: - Nerve: headache, dizziness, sleeplessness, changes in taste - Eye: eye problems, increased or decreased tearing discomfort, vision problems, serious illness with blistering of the eyes, wearing away of the surface “skin” of the eye (corneal erosion).
Danish: - Nerver: Hovedpine, svimmelhed, søvnløshed, smagsændringer - Øjne: Øjenproblemer, øget eller nedsat tåreflåd, synsforstyrrelser, alvorlig sygdom med blæredannelse i øjnene, slitage af øjets “overfladehud” (corneaerosion).
English: Each pack contains 42 capsules or 84 capsules.
Danish: Hver pakning indeholder 42 kapsler eller 84 kapsler.
English: A. MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE
Danish: A. FREMSTILLER AF DET BIOLOGISK AKTIVE STOF OG FREMSTILLER ANSVARLIG FOR BATCHFRIGIVELSE
English: MARKETING AUTHORISATION NUMBER(S) EU/1/11/669/003
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (NUMRE) EU/1/11/669/003
English: Renal failure, blood creatinine increased, glomerular filtration rate decreased, blood urea increased
Danish: Nyresvigt, øget blodcreatinin, reduceret glomerulær filtrationshastighed, øget urinstof i blodet
English: (pain, swelling and redness of hands and/or feet), pigmented skin patches - Kidney: decreased urine volume, changes in blood tests which show the way the kidney is working, kidney impairment and failure - Other: chills, weight decrease, swelling in specific areas and muscle bone pain
Danish: (smerter, hævelse og rødme af hænder og/eller fødder), mørke hudområder - Nyrer: Mindre urinmængde, ændringer i blodprøver der viser, hvordan nyrerne fungerer, nedsat nyrefunktion og nyresvigt - Andet: kulderystelser, vægttab, hævelse i særlige områder og smerter i muskler og knogler
English: The median Tmax for 5-FU was 2.0 hours and the mean AUC(0-12h) and Cmax was 870 ± 405 ng.hr/ml and 165 ± 62 ng/ml, respectively.
Danish: Den mediane Tmaks for 5-FU var 2,0 timer, og den gennemsnitlige AUC(0-12t) og Cmaks var hhv. 870 ± 405 ng.t/ml og 165 ± 62 ng/ml.
English: 4.7 Effects on ability to drive and use machines Teysuno has a moderate influence on the ability to drive and use machines as fatigue, dizziness, blurred vision, and nausea are common adverse reactions of Teysuno in combination with cisplatin.
Danish: Teysuno påvirker i moderat grad evnen til at føre motorkøretøj eller betjene maskiner, eftersom træthed, svimmelhed, tågesyn og kvalme er almindelige bivirkninger af Teysuno i kombination med cisplatin.
English: • Recent or concomitant treatment with brivudine (see section 4.4 and 4.5 for drug-drug interaction).
Danish: • Nylig eller samtidig behandling med brivudin (se pkt.
English: Neutropenia, leukopenia, anaemia, thrombocytopenia
Danish: Neutropeni, leukopeni, anæmi, , trombocytope ni
English: Patients with moderate renal impairment (CrCl 30 to 50 ml/min) who received a reduced dose of 20 mg/m2 twice daily showed no significant increase in mean 5-FU AUC0-inf relative to that of the normal group.
Danish: ), som fik en reduceret dosis på 20 mg/m2 to gange dagligt, viste ingen signifikant stigning i gennemsnitlig 5-FU AUC0-inf i forhold til den normale gruppe.
English: Use caution when driving or operating a machine, as Teysuno may make you tired, nauseous or have blurred vision.
Danish: Teysuno kan gøre dig træt, give dig kvalme eller sløret syn.
English: Ocular toxicity
Danish: Toksicitet i øjnene
English: Teysuno doses
Danish: Teysuno-dosis
English: Pancytopenia, prothrombin time prolonged, international normalised ratio increased, hypoprothrombinaemia, prothrombin time shortened, granulocytosis, leukocytosis, eosinophilia, lymphocytosis, monocyte count decreased, monocyte count increased, thrombocythaemia
Danish: Pancytopeni, forlænget protrombintid, øget INR (International Normalised Ratio), hypoprotrombinæmi, forkortet protrombintid, granulocytose, leukocytose, eosinofili, lymfocytose, reduceret monocyttal, øget monocyttal, trombocytæmi
English: After multiple dose administration (30 mg/m2, expressed as tegafur content, twice daily for 14 days; N=10), the median Tmax of tegafur, gimeracil, and oteracil was 0.8, 1.0, and 2.0 hours, respectively, and the corresponding mean ± SD AUC(0-12h) and Cmax was 19967 ± 6027 ng.hr/ml and 2970 ± 852 ng/ml for tegafur, 1483 ± 527 ng.hr/ml and 305 ± 116 ng/ml for gimeracil, and 692 ± 529 ng.hr/ml and 122 ± 82 ng/ml for oteracil.
Danish: Efter multiple doser (30 mg/m2, udtrykt som tegafurindhold, to gange dagligt i 14 dage, N=10) var den medianeTmaks af tegafur, gimeracil og oteracil hhv. 0,8, 1,0 og 2,0 timer, og den tilsvarende gennemsnitlige ± SD AUC(0-12t) og Cmaks var 19967 ± 6027 ng.t/ml og 2970 ± 852 ng/ml for tegafur, 1483 ± 527 ng.t/ml og 305 ± 116 ng/ml for gimeracil og 692 ± 529 ng.t/ml og 122 ± 82 ng/ml for oteracil.
English: Cardiac failure, acute myocardial infarction, pericardial effusion, atrial fibrillation, angina pectoris, cardiac fibrillation, tachycardia, palpitations
Danish: Hjertesvigt, akut myokardieinfarkt, perikardial effusion, atrieflimmer, angina pectoris, hjerteflimmer, takykardi, palpitationer
English: The use of coumarin-derivative anticoagulant in clinical trials has been associated with elevated INR and gastrointestinal bleeding, bleeding tendency, haematuria, and anaemia in patients receiving Teysuno therapy.
Danish: Brug af coumarin-derivative antikoagulantia hos patienter i behandling med Teysuno er i kliniske forsøg blevet associeret med forhøjet INR og gastrointestinal blødning, blødningstendens, hæmaturi og anæmi.
English: • Severe bone marrow suppression (severe leukopaenia, neutropaenia, or thrombocytopaenia; see section 4.2, Table 5).
Danish: • Svær knoglemarvssuppression (svær leukopeni, neutropeni eller trombocytopeni, se pkt.
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, ATC code: L01BC53.
Danish: ATC-kode: L01BC53.
English: Palmar-plantar erythrodysaesthesia syndrome, rash, skin hyperpigmentation, dry skin, pruritus, alopecia,
Danish: Palmar-plantar erytrodysæstesi syndrom, udslæt, hyperpigmentering af hud, tør hud, pruritus, alopeci
English: Multi-organ failure, performance status decreased, pain, oedema, chest pain, chest discomfort, generalized oedema, face oedema, local swelling, localized oedema, weight increased, early satiety, feeling cold, injection site reaction, malaise
Danish: Multiorgansvigt, nedsat performance status, smerter, ødem, brystsmerter, thorakalt ubehag, generaliseret ødem, ansigtsødem, lokal hævelse, lokaliseret ødem, vægtøgning, tidlig mæthedsfornemmelse, kuldefølelse, reaktion på injektionsstedet, utilpashed
English: Titanium dioxide (E171) Sodium lauryl sulphate Talc
Danish: Titandioxid (E171) Natriumlaurylsulphat Talkum
English: Neutropenic sepsis, septic shock, sepsis, infection, pneumonia, bacteremia, respiratory tract infection, upper respiratory tract infection, pyelonephritis acute, urinary tract infection, pharyngitis, nasopharyngitis, rhinitis, tooth infection, candidiasis, oral herpes, paronychia, furuncle
Danish: Neutropen sepsis, septisk shock, sepsis, infektion, lungebetændelse, bakteriæmi, luftvejsinfektion, øvre luftvejsinfektion, pyelonephritis acuta, urinvejsinfektion, pharyngitis, nasofaryngitis, rhinitis, tandbetændelse, candidiasis, oral herpes, paronychion, furunculus
English: Standard dose (mg/m2)
Danish: Sædvanlig dosis (mg/m2)
English: INFORMATION IN BRAILLE Teysuno 15 mg/4.35 mg/11.8 mg 17.
Danish: INFORMATION I BRAILLE-SKRIFT Teysuno 15 mg/4,35 mg/11,8 mg
English: Leukoencephalopathy, anosmia
Danish: Leukoencefalopati, anosmi
English: Hearing impairment, deafness
Danish: Nedsat hørelse, døvhed
English: Very common side effects (may affect more than 1 in 10 people) include:
Danish: Meget almindelige bivirkninger (kan forekomme hos flere end 1 ud af 10 personer) omfatter:
English: Dose modifications for haematologic toxicities
Danish: Dosisændringer på grund af hæmatologiske toksiciteter
English: INFORMATION IN BRAILLE Teysuno 20 mg/5.8 mg/15.8 mg 17.
Danish: INFORMATION I BRAILLE-SKRIFT Teysuno 20 mg/5,8 mg/15,8 mg
English: - Skin: hair loss, itchiness, rash or dermatitis, skin reaction, dry skin, hand-and-foot reaction
Danish: - Hud: Hårtab, kløe, udslæt (eller hudbetændelse, hudreaktion), tør hud, hånd-og-fod-reaktion
English: Red iron oxide (E172) Titanium dioxide (E171) Sodium lauryl sulphate
Danish: Rød jernoxid (E172) Titandioxid (E171) Natriumlaurylsulphat Talkum
English: Therefore, concurrent administration with Teysuno should be avoided.
Danish: Derfor bør samtidig indgift med Teysuno undgås.
English: Teysuno does not appear to affect male or female fertility in the rat; however, administration at any time after conception resulted in a range of external, visceral, and skeletal foetal abnormalities in rat and rabbit.
Danish: Men indgift på et vilkårligt tidspunkt efter konception resulterede i en række eksterne, viscerale og skeletale abnormaliteter hos rotte- og kaninfostre.
English: Teysuno dose modification criteria
Danish: Kriterier for dosisændring af Teysuno
English: Nordic Pharma
Danish: Ireland Nordic Pharma Ireland
English: The highest single dose of Teysuno taken was 1400 mg; this patient developed leukopenia (Grade 3).
Danish: Den største enkeltdosis, der er blevet taget af Teysuno, var 1400 mg.
English: How to take Teysuno
Danish: Sådan skal du tage Teysuno
English: NAME OF THE MEDICINAL PRODUCT Teysuno 15 mg/4.35 mg/11.8 mg hard capsules
Danish: LÆGEMIDLETS NAVN Teysuno 15 mg/4,35 mg/11,8 mg hårde kapsler
English: No adjustment of the standard dose is recommended for patients with hepatic impairment (see section 5.2).
Danish: Der anbefales ingen justering af den sædvanlige dosis hos patienter med nedsat leverfunktion (se pkt.
English: - are taking other fluoropyrimidine anti-cancer medicine such as fluorouracil and capecitabine, or have had severe and unexpected reactions to fluoropyrimidines - have known genetic deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD) - are pregnant or breast-feeding - have severe blood disorders - have kidney disease requiring dialysis - are being treated now or have been treated in the last 4 weeks with brivudine as part of herpes zoster (chickenpox or shingles) therapy.
Danish: - hvis du har kendt genetisk mangel på enzymet dihydropyrimidin-dehydrogenase (DPD) - hvis du er gravid eller ammer - hvis du har en alvorlig blodsygdom - hvis du har en nyresygdom, der kræver dialyse - hvis du bliver behandlet på nuværende tidspunkt eller inden for de sidste 4 uger har været behandlet med brivudin som en del af herpes zoster (skoldkopper eller helvedesild) behandling .
English: • Eye disorder includes adverse reactions of eye pruritus, ocular hyperaemia, eye irritation, eye disorder, and foreign body sensation in eyes.
Danish: • Øjenlidelser omfatter bivirkninger i form af pruritus i øjnene, okulær hyperæmi, øjenirritation,
English: Erectile dysfunction, breast tenderness, nipple pain
Danish: Erektil dysfunktion, ømme bryster, smerter i brystvorter
English: • Moderate renal impairment (CrCl 30 to 50 ml/min) The recommended standard dose in patients with moderate renal impairment is 20 mg/m2 twice daily (expressed as tegafur content) (see sections 4.8 and 5.2).
Danish: Den anbefalede, sædvanlige dosis hos patienter med moderat nedsat nyrefunktion er 20 mg/m2 to gange dagligt (udtrykt som tegafurindhold) (se pkt.
English: Hyperglycaemia, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, hypophosphatameia, hypermagnesaemia, gout, hypoproteinaemia, hyperglobulinaemia, hyperlipidaemia, oral intake reduced
Danish: Hyperglykæmi, øget alkalisk phosphatase i blod, øget lactatdehydrogenase i blod, hypofosfatæmi, hypermagnesiæmi, urinsyregigt, hypoproteinæmi, hyperglobulinæmi, hyperlipidæmi, nedsat peroralt indtag
English: Exfoliative rash, skin exfoliation, necrolytic migratory erythema, blood blister, dermatitis allergic, skin reaction, dermatitis acneiform, erythema, increased tendency to bruise, purpura, hyperhidrosis, night sweats, nail atrophy, pigmentation disorder, skin discoloration, hypertrichosis
Danish: Eksfoliativt udslæt, afskalning af huden, nekrolytisk migratorisk erytem, klemmelus, allergisk dermatitis, hudreaktion, dermatitis acneiform, erytem, øget tendens til at få blå mærker, purpura, hyperhidrose, nattesved, negleatrofi, pigmenteringssygdom, misfarvning af huden, hypertrikose
English: Teysuno is contraindicated during breast-feeding (see section 4.3).
Danish: Teysuno er kontraindiceret under amning (se pkt.
English: Breast-feeding must be discontinued while receiving treatment with Teysuno.
Danish: Amning skal stoppes under behandling med Teysuno.
English: NAME OF THE MEDICINAL PRODUCT Teysuno 20 mg/5.8 mg/15.8 mg hard capsules
Danish: LÆGEMIDLETS NAVN Teysuno 20 mg/5,8 mg/15,8 mg hårde kapsler
English: Calculated creatinine clearance ≥30 ml/mina Neutrophils ≥1.5 x 109/l
Danish: Beregnet creatinin-clearance ≥30 ml/mina
English: - acute liver failure - pancreas infection - muscle breakdown - loss of sense of smell - sun allergy - widespread blood clotting and bleeding - disease affecting the white matter of the brain - serious illness with blistering of the skin, mouth and genitals recurrence (reactivation) of hepatitis B infection when you have had hepatitis B in the past (a liver infection)
Danish: - Alvorlig sygdom med blæredannelser på hud, mund og kønsorganer - tilbagefald (reaktivering) af hepatitis B-infektion, hvis du tidligere har haft hepatitis B (en leverinfektion)
English: Common side effects (may affect 1 to 10 in 100 people) include:
Danish: Almindelige bivirkninger (kan forekomme hos mellem 1 til 10 ud af 100 personer) omfatter:
English: Teysuno contains
Danish: Teysuno indeholder:
English: The hard capsules have a white body and white cap imprinted "TC442" in grey.
Danish: De hårde kapsler består af en hvid kapsel og en hvid kapselende med “TC442” præget i gråt.
English: Gastrointestinal haemorrhage, stomatitis, gastrointestinal inflammation, flatulence, abdominal pain, dysphagia, abdominal discomfort, dyspepsia, dry mouth
Danish: Gastrointestinal blødning, stomatitis, mavetarm-betændelse, flatulens, abdominalsmerter, dysfagi, abdominalt ubehag, dyspepsi, mundtørhed
English: Respiratory, tThoracic and mediastinal disorders
Danish: Luftveje, thorax og mediastinum
English: Standard anti-diarrhoeal therapy (e.g., loperamide) and intravenous fluids/electrolytes should be initiated early when diarrhoea develops.
Danish: væske/elektrolytter bør indledes tidligt ved udvikling af diarré.
English: Red iron oxide (E172) Yellow iron oxide (E172) Indigo carmine (E132) Carnauba wax Bleached shellac
Danish: Rød jernoxid (E172) Gul jernoxid (E172) Indigocarmin (E132) Carnaubavoks Bleget shellac Glyceryl monooleat
English: Rhabdomyolysis
Danish: Rabdomyolose
English: Suspend treatment until resumption criterion (≥30 ml/min) is met and then start treatment at one reduced dose level
Danish: Indstil behandlingen, indtil kriterierne for genoptagelse (≥30 ml/min.)
English: o If you vomit more than two times in 24 hours, stop taking Teysuno and contact your doctor immediately.
Danish: Du må ikke tage en ny dosis som erstatning for den, du har kastet op. o Hvis du kaster op mere end to gange på 24 timer, skal du holde op med at tage Teysuno og kontakte lægen med det samme.