FrancophonIA/ELRC3.0 huggingface dataset:
English: The risk of hypokalaemia is greatest in patients with cirrhosis of the liver, in patients experiencing rapid diuresis, in patients who are receiving inadequate electrolytes and in patients receiving concomitant therapy with corticosteroids or ACTH (see section 4.5).
Slovenian: Tveganje za hipokaliemijo je največje pri bolnikih s cirozo jeter, bolnikih, ki se jim pojavi hitra diureza, bolnikih, ki ne uživajo dovolj elektrolitov, in tistih, ki sočasno dobivajo kortikosteroide ali ACTH (glejte poglavje 4.5).
English: Potassium and magnesium excretion are increased, uric acid excretion is decreased.
Slovenian: Izločanje kalija in magnezija se poveča, izločanje sečne kisline pa se zmanjša.
English: Combination of an ACE-inhibitor with a thiazide diuretic produces a synergistic effect and also lessens the risk of hypokalaemia provoked by the diuretic alone.
Slovenian: Kombinacija zaviralca ACE in tiazidnega diuretika povzroči sinergističen učinek in tudi zmanjša tveganje hipokaliemije, ki jo povzroči diuretik sam.
English: Calcium salts and plasma calcium increasing medicinal products: Rise in serum calcium concentration is to be anticipated in case of concomitant administration of hydrochlorothiazide; therefore close monitoring of serum calcium is required.
Slovenian: Kalcijeve soli in zdravila, ki povečujejo koncentracijo kalcija v plazmi: V primeru sočasne uporabe hidroklorotiazida je treba pričakovati povečanje koncentracija kalcija v serumu, zato je treba kalcij v serumu natančno kontrolirati.
English: • If you have abnormal amounts of salt substances (calcium, potassium, sodium) in your blood
Slovenian: • če imate nenormalno količino soli (kalcija, kalija, natrija) v krvi.
English: Pregnancy: ACE inhibitors such as ramipril, or Angiotensin II Receptor Antagonists (AIIRAs) should not be initiated during pregnancy.
Slovenian: Nosečnost: Med nosečnostjo se ne sme uvesti zaviralcev ACE, kakršen je ramipril, ali antagonistov receptorjev angiotenzina II (AIIRA).
English: This could be a sign of pancreatitis (inflammation of the pancreas)
Slovenian: To je lahko znak pankreatitisa (vnetja trebušne slinavke).
English: The CHMP adopted the harmonised wording: “The dose should be individualised according to the patient profile (see section 4.4) and blood pressure control.
Slovenian: CHMP je sprejel usklajeno besedilo: „Odmerek je treba prilagoditi vsakemu bolniku posebej glede na njegov profil (glejte poglavje 4.4) in uravnavanje krvnega tlaka.
English: Penicillin: hydrochlorothiazide is excreted in the distal tubulus, and reduces excretion of penicillin.
Slovenian: Penicilin: Hidroklorotiazid se izloča v distalnem tubulu in zmanjša izločanje penicilina.
English: Hydrochlorothiazide, in cases of prolonged exposure during the third trimester of pregnancy, may cause a foeto-placental ischaemia and risk of growth retardation.
Slovenian: Hidroklorotiazid lahko med dolgotrajno izpostavljenostjo v tretjem trimesečju nosečnosti povzroči feto-placentno ishemijo in tveganje za upočasnitev rasti.
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORMS, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTES OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
Slovenian: DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, PREDLAGATELJEV IN IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
English: These can be signs of liver problems such as hepatitis (inflammation of the liver) or liver damage.
Slovenian: To so lahko znaki težav z jetri, npr. hepatitisa (vnetja jeter) ali okvare jeter.
English: • Blotches on your skin and cold extremities
Slovenian: • pege na koži in hladni udi
English: The maximum antihypertensive effect of continued treatment with ramipril is generally apparent after 3 to 4 weeks.
Slovenian: Največji antihipertenzivni učinek trajnega zdravljenja z ramiprilom je praviloma opazen po 3 do 4 tednih.
English: • Medicines for diabetes such as oral glucose lowering medicines and insulin.
Slovenian: • zdravila proti sladkorni bolezni (npr. peroralna zdravila za zniževanje glukoze in insulin).
English: Evropská 2590/33c
Slovenian: Evropská 2590/33c 16000 Praha 6
English: Carbamazepine: risk of hyponatraemia due to additive effect with hydrochlorothiazide.
Slovenian: Karbamazepin: Tveganje hiponatriemije zaradi aditivnega učinka hidroklorotiazida.
English: More frequent monitoring is advised in the initial phase of treatment and in patients with impaired renal function, those with concomitant collagen disease (e.g. lupus erythematosus or scleroderma), and all those treated with other medicinal products that can cause changes in the blood picture (see sections 4.5 and 4.8).
Slovenian: Pogostejše kontrole so priporočljive v uvodnem obdobju zdravljenja, pa tudi pri bolnikih z okvarjenim delovanjem ledvic, sočasno kolagensko boleznijo (npr. eritematoznim lupusom ali sklerodermo) ter pri vseh bolnikih, zdravljenih z zdravili, ki lahko spremenijo krvno sliko (glejte poglavji 4.5 in 4.8).
English: Nonsteroidal anti-inflammatory drugs and acetylsalicylic acid: Reduction of the antihypertensive effect of TRITAZIDE is to be anticipated.
Slovenian: Nesteroidna protivnetna zdravila in acetilsalicilna kislina: Pričakovati je mogoče zmanjšanje antihipertenzivnega učinka TRITAZIDE.
English: • If you have heart, liver or kidney problems
Slovenian: • če imate težave s srcem, jetri ali ledvicami.
English: the CHMP has recommended the amendment of the Marketing Authorisation(s) for which the Summary of Product Characteristics, labelling and package leaflet are set out in Annex III for Tritazide and associated names (see Annex I).
Slovenian: je CHMP priporočil dopolnitev dovoljenj(a) za promet, za katera so povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo določeni v Dodatku III za zdravilo Tritazide in z njim povezana imena (glejte Dodatek I).
English: As with other ACE inhibitors, ramipril may be less effective in lowering blood pressure in black people than in non black patients, possibly because of a higher prevalence of hypertension with low renin level in the black hypertensive population.
Slovenian: Tako kot drugi zaviralci ACE lahko tudi ramipril manj učinkovito zniža krvni tlak pri bolnikih-črncih kot nečrncih, morda zaradi večje prevalence hipertenzije z majhno koncentracijo renina pri črni hipertenzivni populaciji.
English: In conclusion, the CHMP adopted a harmonised wording according to the PhVWP recommendations: “Tritazide is not recommended during the first trimester of pregnancy (see section 4.4) and contraindicated during the second and third trimesters of pregnancy (see section 4.3).
Slovenian: CHMP je sprejel usklajeno besedilo v skladu s priporočili skupine PhVWP: „Zdravilo Tritazide v prvem trimesečju nosečnosti (glejte poglavje 4.4) ni priporočljivo, v drugem in tretjem trimesečju nosečnosti (glejte poglavje 4.3) pa je kontraindicirano.
English: Suggested measures include primary detoxification (gastric lavage, administration of adsorbents) and measures to restore haemodynamic stability, including administration of alpha 1 adrenergic agonists or angiotensin II (angiotensinamide) administration.
Slovenian: Med priporočljivimi ukrepi so primarna detoksifikacija (izpiranje želodca, uporaba adsorbensov) in ukrepi za obnovitev hemodinamske stabilnosti, vključno z uporabo adrenergičnih agonistov alfa 1 ali angiotenzina II (angiotenzinamid).
English: Considering that no major concern can be established concerning the safety, efficacy and clinical adverse event of the ramipril/HCTZ combination in non responders to HCTZ and ramipril alone, the CHMP adopted the following two harmonised wordings for indications: -Treatment of essential hypertension -This fixed dose combination is indicated in patients whose blood pressure is not adequately controlled with ramipril alone or hydrochlorothiazide alone.
Slovenian: Ker ni opaziti večje zaskrbljenosti glede varnosti, učinkovitosti in kliničnih neželenih učinkov za kombinacijo ramipril/HCTZ pri bolnikih, ki se ne odzivajo na samostojno zdravljenje s HCTZ ali ramiprilom, je CHMP sprejel naslednji usklajeni besedili za indikacije: - Zdravljenje esencialne hipertenzije - Ta kombinacija učinkovin v fiksnem odmerku je indicirana pri bolnikih, pri katerih krvnega tlaka ni mogoče ustrezno uravnavati samo z ramiprilom ali hidroklorotiazidom.
English: (See also 5.3 'Preclinical safety data').
Slovenian: hiperkaliemija) (glejte tudi poglavje 5.3 Predklinični podatki o varnosti).
English: • Painful, red, and swollen joints
Slovenian: • boleči, rdeči in otekli sklepi.
English: Peak concentrations of ramiprilat in these patients, however, are not different from those seen in subjects with normal hepatic function.
Slovenian: Vendar se največja koncentracija ramiprilata pri teh bolnikih ne razlikuje od tiste pri osebah z normalnim delovanjem jeter.
English: • Allopurinol (used to lower the uric acid in your blood)
Slovenian: • alopurinol (uporablja se za zniževanje sečne kisline v krvi).
English: Very rare (affects less than 1 in 10,000 people)
Slovenian: Zelo redki (pojavijo se pri manj kot 1 do 10.000 bolnikov)
English: SANOFI-AVENTIS GMBH OSTERREICH SATURN Tower Leonard-Bernstein-Straße 10 A-1220 Vienna Austria
Slovenian: SANOFI-AVENTIS GMBH OSTERREICH SATURN Tower Leonard-Bernstein-Straße 10 A-1220 Dunaj
English: The administration of the fixed combination of ramipril and hydrochlorothiazide is usually recommended after dosage titration with one of the individual components.
Slovenian: Uporaba fiksne kombinacije ramiprila in hidroklorotiazida je po navadi priporočljiva po titriranju odmerjanja z eno od posameznih sestavin.
English: How to store TRITAZIDE Further information
Slovenian: Shranjevanje zdravila TRITAZIDE Dodatne informacije
English: This is more likely to happen when you start taking TRITAZIDE or start taking a higher dose.
Slovenian: Verjetnost omotice je večja, ko začnete jemati zdravilo TRITAZIDE ali začnete jemati večji odmerek.
English: Iodine containing contrast media: in case of dehydration induced by diuretics including hydrochlorothiazide, there is increased risk of acute renal impairment, in particular when use of important doses of iodine containing contrast media.
Slovenian: Kontrastna sredstva, ki vsebujejo jod: V primeru dehidracije zaradi diuretikov (vključno s hidroklorotiazidom) obstaja večje tveganje akutne okvare ledvic, zlasti med uporabo večje količine kontrastnih sredstev, ki vsebujejo jod.
English: Malta Netherlands
Slovenian: Malta Nizozemska
English: ANNEX IISCIENTIFIC CONCLUSIONS AND GROUNDS FOR AMENDMENT OF THE SUMMARIES OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET PRESENTED BY THE EMEA
Slovenian: DODATEK IIZNANSTVENI ZAKLJUČKI IN PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJA IN NAVODILA ZA UPORABO, KI JIH JE PREDSTAVILA EMEA
English: TRITAZIDE is contraindicated in severe renal impairment due to the hydrochlorothiazide component (creatinine clearance < 30 ml/min) (see section 4.3).
Slovenian: TRITAZIDE je zaradi hidroklorotiazida kontraindiciran pri bolnikih s hudo okvaro ledvic (očistek kreatinina < 30 ml/min) (glejte poglavje 4.3).
English: Antidiabetic agents including insulin: Hypoglycaemic reactions may occur.
Slovenian: Antidiabetična zdravila, vključno z insulinom: Pojavi se lahko hipoglikemična reakcija.
English: The pharmacokinetics of hydrochlorothiazide has not been studied in patients with cardiac failure.
Slovenian: Farmakokinetika hidroklorotiazida ni raziskana pri bolnikih s srčnim popuščanjem.
English: Particularly close blood glucose monitoring is therefore recommended in the initial phase of co-administration.
Slovenian: Zato je v uvodnem obdobju sočasne uporabe priporočljivo posebno natančno kontroliranje glukoze v krvi.
English: TRITAZIDE might affect the results of the test
Slovenian: Zdravilo TRITAZIDE lahko vpliva na rezultate te preiskave.
English: Your lithium amount will need to be closely checked by your doctor
Slovenian: Zdravnik vam bo moral natančno kontrolirati količino litija.
English: • Dry tickly cough or bronchitis
Slovenian: • suh, dražeč kašelj ali bronhitis
English: This difference is related to the saturable capacity of the enzyme to bind ramiprilat.
Slovenian: Razlika je povezana s saturabilno kapaciteto encima za vezavo ramiprilata.
English: Depressed mood, apathy, anxiety, nervousness, sleep disorders including somnolence,
Slovenian: Psihiatrične motnje depresivno razpoloženje, apatija, anksioznost, živčnost, motnje spanja, vključno z zaspanostjo,
English: Lithium levels must be monitored.
Slovenian: Koncentracijo litija je treba kontrolirati.
English: Patients with strongly activated renin-angiotensin-aldosterone system are at risk of an acute pronounced fall in blood pressure and deterioration of renal function due to ACE inhibition, especially when an ACE inhibitor or a concomitant diuretic is given for the first time or at first dose increase.
Slovenian: - Bolniki z močno aktiviranim sistemom renin-angiotenzin-aldosteron Pri bolnikih z močno aktiviranim sistemom renin-angiotenzin-aldosteron obstaja tveganje akutnega, izrazitega padca krvnega tlaka in poslabšanja delovanja ledvic zaradi zavrtja ACE, zlasti če je zaviralec ACE ali sočasni diuretik uporabljen prvič ali prvič v večjem odmerku.
English: TRITAZIDE is a combination of two medicines called ramipril and hydrochlorothiazide.
Slovenian: Zdravilo TRITAZIDE je kombinacija dveh zdravil: ramiprila in hidroklorotiazida.
English: Signs of an allergic reaction may include a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
Slovenian: Med znaki alergijske reakcije so lahko izpuščaj, težave s požiranjem ali dihanjem, oteklost ustnic, obraza, žrela ali jezika.
English: • Musculoskeletal rigidity or not being able to move your jaw (tetany)
Slovenian: • mišično-skeletna togost ali nezmožnost za premikanje čeljusti (tetanija)
English: This is because TRITAZIDE can affect the way some other medicines work.
Slovenian: Zdravilo TRITAZIDE namreč lahko vpliva na delovanje nekaterih drugih zdravil.
English: Hydrochlorothiazide belongs to a group of medicines called “thiazide diuretics” or water tablets.
Slovenian: Hidroklorotiazid spada v skupino zdravil, ki jih imenujemo tiazidni diuretiki (ali "tablete za odvajanje vode").
English: SANOFI-AVENTIS SPA Viale Bodio, 37/b 20158 Milano Italy
Slovenian: SANOFI-AVENTIS SPA Viale Bodio, 37/b 20158 Milano Italija
English: Hydrochlorothiazide stimulates renal calcium reabsorption and may cause hypercalcaemia.
Slovenian: Hidroklorotiazid stimulira reabsorpcijo kalcija v ledvicah in lahko povzroči hiperkalciemijo.
English: The maximum permitted doses are 5 mg of ramipril and 25 mg of hydrochlorothiazide daily.
Slovenian: Največji dovoljeni odmerek je 5 mg ramiprila in 25 hidroklorotiazida na dan.
English: [See Annex I - To be completed nationally]
Slovenian: [Glejte Dodatek I - Izpolni država članica]
English: A switch to a suitable alternative treatment should be carried out in advance of a planned pregnancy.
Slovenian: Pred načrtovano nosečnostjo je treba vnaprej opraviti prehod na ustrezno drugačno zdravljenje.
English: The bioavailability of the active metabolite ramiprilat after oral administration of 2.5 mg and 5 mg ramipril is 45 %.
Slovenian: Biološka uporabnost aktivnega presnovka ramiprilata je po peroralni uporabi 2,5 mg in 5 mg ramiprila 45 %.
English: Antihypertensive agents (e.g. diuretics) and other substances that may decrease blood pressure (e.g. nitrates, tricyclic antidepressants, anaesthetics, acute alcohol intake, baclofen, alfuzosin, doxazosin, prazosin, tamsulosin, terazosin): Potentiation of the risk of hypotension is to be anticipated (see section 4.2 for diuretics).
Slovenian: Antihipertenzivna zdravila (npr. diuretiki) in druge snovi, ki lahko znižajo krvni tlak (npr. nitrati, triciklični antidepresivi, anestetiki, akutno pitje alkohola, baklofen, alfuzosin, doksazosin, prazosin, tamsulosin, terazosin): Pričakovati je treba večje tveganje hipotenzije (glejte poglavje 4.2 za diuretike).
English: Oral anticoagulants: anticoagulant effect may be decreased due to concomitant use of hydrochlorothiazide.
Slovenian: Peroralni antikoagulansi: Antikoagulantni učinek se lahko zaradi sočasne uporabe hidroklorotiazida zmanjša.
English: Ramipril and hydrochlorothiazide are excreted in breast milk to such an extent that effects on the suckling child are likely if therapeutic doses of ramipril and hydrochlorothiazide are administered to breast-feeding women.
Slovenian: Ramipril in hidroklorotiazid se v materinem mleku izločata v tolikšni meri, da so med uporabo terapevtskih odmerkov ramiprila in hidroklorotiazida pri doječi ženski verjetni učinki na dojenčka.
English: • Faster heart rate, uneven or forceful heartbeat (palpitations), chest pain, tightness in your chest or more serious problems including heart attack and stroke
Slovenian: • hitrejše bitje srca, neenakomerno ali močno bitje srca (palpitacije), bolečine v prsih, tiščanje v prsih ali resnejše težave, vključno srčnim infarktom in možgansko kapjo.
English: If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Slovenian: Če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
English: [See Annex I - To be completed nationally] {Name and address} {tel} {fax} {e-mail}
Slovenian: [Glejte Dodatek I - Izpolni država članica] {Ime in naslov} {tel.} {faks} {e-pošta}
English: TRITAZIDE may increase the amount of lithium in your blood.
Slovenian: Zdravilo TRITAZIDE lahko poveča količino litija v krvi.
English: Corticosteroids, ACTH, amphotericin B, carbenoxolone, large amounts of liquorice, laxatives (in case of a prolonged use), and other kaliuretic or plasma potassium decreasing agents: increased risk of hypokalaemia.
Slovenian: Kortikosteroidi, ACTH, amfotericin B, karbenoksolon, velika količina likviricije, odvajala (v primeru dolgotrajne uporabe) ter druga zdravila, ki delujejo kaliuretično ali zmanjšujejo koncentracijo kalija v plazmi: Večje tveganje hipokaliemije.
English: Allopurinol, immunosuppressants, corticosteroids, procainamide, cytostatics and other substances that may change the blood cell count.
Slovenian: Alopurinol, imunosupresivi, kortikosteroidi, prokainamid, citostatiki in druge snovi lahko spremenijo krvno sliko.
English: Any unused product or waste material should be disposed of in accordance with local requirements.
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
English: In plasma and tissue, this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin.
Slovenian: Ta encim v plazmi in tkivih katalizira pretvorbo angiotenzina I v aktivno vazokonstrikcijsko snov angiotenzin II ter razgradnjo vazodilatatorja bradikinina.
English: Extracorporeal treatments leading to contact of blood with negatively charged surfaces such as dialysis or haemofiltration with certain high-flux membranes (e.g. polyacrylonitril membranes) and low density lipoprotein apheresis with dextran sulphate due to increased risk of severe anaphylactoid reactions (see section 4.3).
Slovenian: Zunajtelesna zdravljenja, med katerimi pride kri v stik z negativno nabitimi površinami, npr. dializa ali hemofiltracija z določenimi visokopretočnimi membranami (npr. poliakrilonitrilnimi membranami) in afereza lipoproteina majhne gostote z dekstranovim sulfatom, zaradi večjega tveganja za hude anafilaktoidne reakcije (glejte poglavje 4.3).
English: Ramiprilat, the active metabolite of the prodrug ramipril, inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II).
Slovenian: Ramiprilat, aktivni presnovek ramiprila, zavira encim dipeptidilkarboksipeptidazo I (sinonima: angiotenzinska konvertaza, kininaza II).
English: When pregnancy is diagnosed, treatment with ACE inhibitors should be stopped immediately, and, if appropriate, alternative therapy should be started.
Slovenian: Ko je nosečnost potrjena, je treba zdravljenje z zaviralci ACE nemudoma ustaviti in po potrebi pričeti drugačno zdravljenje.
English: Hydrochlorothiazide may attenuate the effect of antidiabetic medicines.
Slovenian: Hidroklorotiazid lahko oslabi učinek zdravil proti sladkorni bolezni.
English: • Swelling of the face, lips or throat which make it difficult to swallow or breathe, as well as itching and rashes.
Slovenian: • Oteklost obraza, ustnic ali žrela, ki otežijo požiranje ali dihanje, ali srbenje in izpuščaj.
English: In conclusions, the CHMP adopted a harmonised wording in line with PhVWP wording on use of AEC-I in pregnancy.
Slovenian: CHMP je sprejel usklajeno besedilo v skladu z besedilom skupine PhVWP o uporabi ACE-I med nosečnostjo.
English: Hydrochlorothiazide is excreted in human milk.
Slovenian: Hidroklorotiazid se pri človeku izloča v materinem mleku.
English: Concomitant use of thiazide diuretics may increase the risk of lithium toxicity and enhance the already increased risk of lithium toxicity with ACE inhibitors.
Slovenian: Sočasna uporaba tiazidnih diuretikov lahko poveča tveganje za toksične učinke litija in stopnjuje že tako večje tveganje za toksične učinke litija ob zaviralcih ACE.
English: These include medicines for constipation, diuretics (water tablets), amphotericin B (used for fungal infections) and ACTH (used to test if your adrenal glands are working properly)
Slovenian: diuretiki (zdravila za odvajanje vode), amfotericin B (uporablja se za zdravljenje glivičnih okužb) in ACTH (uporablja se za preverjanje, ali nadledvične žleze dobro delujejo).
English: Colestyramine or other enterally administered ion exchangers: reduced absorption of hydrochlorothiazide.
Slovenian: Holestiramin in drugi enteralno uporabljeni ionski izmenjevalci: Manjša absorpcija hidroklorotiazida.
English: Newborns whose mothers have taken ACE inhibitors should be closely observed for hypotension, oliguria and hyperkalaemia (see also sections 4.3 and 4.4).
Slovenian: Novorojenčke mater, ki so jemale zaviralce ACE, je treba natančno nadzirati glede hipotenzije, oligurije in hiperkaliemije (glejte tudi poglavji 4.3 in 4.4).
English: • Severe skin reactions including rash, ulcers in your mouth, worsening of a pre-existing skin disease, reddening, blistering or detachment of skin (such as Stevens-Johnson syndrome, toxic epidermal necrolysis or erythema multiform).
Slovenian: • Med hudimi kožnimi reakcijami so izpuščaj, razjede v ustih, poslabšanje že obstoječe bolezni kože, pordelost, mehurji ali odstopanje kože (npr. Stevens-Johnsonov sindrom, toksična epidermalna nekroliza ali multiformni eritem).
English: Czech Republic sanofi-aventis, s.r.o.
Slovenian: Češka sanofi-aventis, s.r.o.
English: Serious adverse reactions include angioedema or anaphylactic reaction, renal or hepatic impairment, pancreatitis, severe skin reactions and neutropenia/agranulocytosis.
Slovenian: Med resnimi neželenimi učinki so angioedem ali anafilaktična reakcija, okvara ledvic ali jeter, pankreatitis, hude kožne reakcije in nevtropenija/agranulocitoza.
English: Ramipril is almost completely metabolised to ramiprilat, and to the diketopiperazine ester, the diketopiperazine acid, and the glucuronides of ramipril and ramiprilat.
Slovenian: Ramipril se skoraj povsem presnovi v ramiprilat ter v diketopiperazinski ester, diketopiperazinsko kislino in glukuronida ramiprila in ramiprilata.
English: Administration of ramipril to patients with hypertension leads to a reduction in supine and standing blood pressure without a compensatory rise in heart rate.
Slovenian: Uporaba ramiprila pri bolnikih s hipertenzijo zniža krvni tlak v leže in stoje, brez kompenzacijskega povečanja srčne frekvence.
English: Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnesaemia.
Slovenian: Tiazidi povečajo izločanje magnezija v urinu; posledica je lahko hipomagneziemija.