FrancophonIA/ELRC3.0 huggingface dataset:
English: It is believed that these symptoms are due to an improvement in the body's immune response, enabling the body to fight infections that may have been present with no obvious symptoms.
Slovenian: Domnevajo, da so ti simptomi posledica izboljšanja imunskega odziva, kar telesu omogoči, da se bojuje proti okužbam, ki so bile že prej prisotne, a ni bilo očitnih simptomov.
English: OESTROGEN-BASED CONTRACEPTIVES Drospirenone Ethinylestradiol (3 mg/0.02 mg once daily)
Slovenian: ESTROGENSKI KONTRACEPTIVI drospireron/etinilestradiol (3 mg/0,02 mg enkrat na dan)
English: Each bottle contains 30 tablets.
Slovenian: Ena plastenka vsebuje 30 tablet.
English: In vitro selection of darunavir-resistant virus from wild type HIV-1 was lengthy (> 3 years).
Slovenian: In vitro selekcija virusa, odpornega na darunavir, iz divjega tipa virusa HIV-1 je bila dolgotrajna (> 3 leta).
English: EXP Do not use after 6 weeks of first opening the bottle.
Slovenian: EXP Porabite v 6 tednih od prvega odprtja plastenke.
English: If you belong to this age group, please discuss with your doctor if you can use Symtuza.
Slovenian: Če sodite v to starostno skupino, se s svojim zdravnikom pogovorite, ali lahko uporabljate zdravilo Symtuza.
English: Treatment of overdose with Symtuza consists of general supportive measures, including monitoring of vital signs as well as observation of the clinical status of the patient.
Slovenian: Zdravljenje prevelikega odmerjanja zdravila Symtuza predstavljajo splošni podporni ukrepi, vključno s spremljanjem vitalnih znakov in opazovanjem kliničnega stanja bolnika.
English: Symtuza has only been used in limited numbers of patients 65 years or older.
Slovenian: Zdravilo Symtuza je bilo uporabljeno le pri majhnem številu bolnikov, starih 65 let ali več.
English: In juvenile rats receiving darunavir up to days 23-26 (equivalent to less than 2 years of age in humans), increased mortality was observed with convulsions in some animals.
Slovenian: Pri mladih podganah, ki so prejemale darunavir do 23-26 dni (ekvivalentno starosti 2 leti ali manj pri človeku), so pri nekaterih živalih opazili povečano smrtnost s konvulzijami.
English: Tenofovir is efficiently removed by haemodialysis with an extraction coefficient of approximately 54%.
Slovenian: Tenofovir lahko učinkovito odstranimo s hemodializo s koeficientom ekstrakcije približno 54%.
English: Symtuza might reduce its effectiveness.
Slovenian: Zdravilo Symtuza lahko zmanjša njihovo učinkovitost.
English: • if you notice symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, tell your doctor immediately.
Slovenian: • če opazite kakršne koli simptome kot so mišična oslabelost, oslabelost, ki se najprej pojavi v dlaneh in stopalih in se nato širi proti trupu, palpitacije, tremor ali hiperaktivnost, takoj obvestite zdravnika.
English: Darunavir After a 400/100 mg [
Slovenian: Darunavir Po odmerjanju 400/100 mg s
English: MedDRA system organ class Frequency category
Slovenian: Organski sistem po klasifikaciji MedDRA kategorija pogostnosti
English: Then take the next dose at your usual time.
Slovenian: Nato vzemite naslednji odmerek kot običajno.
English: Skin rash may affect more than 1 in 10 patients receiving Symtuza.
Slovenian: Kožni izpuščaj se lahko pojavi pri več kot 1 od 10 bolnikov, ki prejemajo zdravilo Symtuza.
English: The type of food does not affect exposure to Symtuza.
Slovenian: Vrsta hrane ne vpliva na izpostavljenost zdravilu Symtuza.
English: If you notice any of these symptoms tell your doctor.
Slovenian: Če opazite katerega koli od teh simptomov, obvestite svojega zdravnika.
English: Other severe side effects, seen up to 1 patient in 10, were diabetes, increased blood fat levels and symptoms of infection.
Slovenian: Drugi resni neželeni učinki, ki so jih opažali pri največ 1 od 10 bolnikov, so bili sladkorna bolezen, zvišanje maščob v krvi in simptomi okužbe.
English: People taking Symtuza may still develop infections or other illnesses associated with HIV infection.
Slovenian: Pri osebah, ki jemljejo zdravilo Symtuza, se lahko še vedno pojavijo okužbe ali druge bolezni, povezane z okužbo z virusom HIV.
English: Pharmacotherapeutic group: Antivirals for systemic use, antivirals for treatment of HIV infection, combinations ATC code: J05AR22
Slovenian: Farmakoterapevtska skupina: Zdravila za sistemsko zdravljenje virusnih infekcij, zdravila za zdravljenje infekcij s HIV, kombinacije, oznaka ATC: J05AR22
English: Table 1: Interactions between the individual components of Symtuza and other medicinal products
Slovenian: Preglednica 1: Medsebojno delovanje med posameznimi učinkovinami zdravila Symtuza in drugimi zdravili
English: Inflammation of the pancreas (pancreatitis) has been reported in up to 1 patient in 100.
Slovenian: O vnetju trebušne slinavke (pankreatitisu) so poročali pri največ 1 od 100 bolnikov.
English: Medicinal products that decrease renal function may increase concentrations of emtricitabine.
Slovenian: Zdravila, ki zmanjšujejo ledvično funkcijo, lahko povečajo koncentracijo emtricitabina.
English: • if you have had problems with your kidneys.
Slovenian: • če ste že imeli težave z ledvicami.
English: • The tablet should not be crushed, but swallowed whole.
Slovenian: • Tableto ne smete zdrobiti ampak jo morate celo pogoltniti.
English: The risk of muscle damage might be increased.
Slovenian: Lahko se zveča tveganje za poškodbo mišic.
English: While effective viral suppression with antiretroviral therapy (ART) has been proven to substantially reduce the risk of sexual transmission, a residual risk cannot be excluded.
Slovenian: Čeprav je dokazano, da učinkovita virusna supresija s protiretrovirusnimi zdravili bistveno zmanjša tveganje spolnega prenosa, preostalega tveganja ni mogoče izključiti.
English: There are some medicines that you must not combine with Symtuza.
Slovenian: Obstajajo določena zdravila, ki jih ne smete kombinirati z zdravilom Symtuza.
English: It is not known whether emtricitabine or tenofovir can be removed by peritoneal dialysis.
Slovenian: Ni znano, ali je mogoče emtricitabin in tenofovir odstraniti s peritonealno dializo.
English: The following viral load values were observed for these subjects at Week 96: 54 copies/mL, 78 copies/mL, 111 copies/mL, 152 copies/mL, and 210 copies/mL.
Slovenian: Pri teh preiskovancih so po 96 tednih izmerili naslednje virusno breme: 54 kopij/ml, 78 kopij/ml, 111 kopij/ml, 152 kopij/ml in 210 kopij/ml.
English: Week 96* D/C/F/TAF
Slovenian: v 96. tednu* D/C/F/TAF
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Symtuza in one or more subsets of the paediatric population in the treatment of HIV-1 infection (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Symtuza za eno ali več podskupin pediatrične populacije za zdravljenje okužbe z virusom HIV-1 (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Darunavir Results from a mass balance study with [
Slovenian: Darunavir Rezultati študije masnega ravnovesja s
English: This medicine contains less than 1 mmol sodium (23 mg) per dosage unit, that is to say essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na odmerek, kar v bistvu pomeni ‘brez natrija'.
English: However, unbound darunavir concentrations were approximately 55% (Child-Pugh Class A) and 100% (Child-Pugh Class B) higher, respectively.
Slovenian: Koncentracije nevezanega darunavirja pa so bile približno 55% (razred A po Child-Pughovi lestvici) in 100% (razred B po Child-Pughovi lestvici) višje.
English: Ex vivo binding of tenofovir alafenamide to human plasma proteins in samples collected during clinical studies was approximately 80%.
Slovenian: Ex vivo je bila vezava alafenamidtenofovirata na humane plazemske beljakovine v vzorcih, zbranih v okviru kliničnih študij, približno 80%.
English: Postpartum (6-12 weeks) N = 6
Slovenian: Obdobje po porodu (6-12 tednov) (n=6)
English: Do not operate machines or drive if you feel dizzy after taking Symtuza.
Slovenian: Ne upravljajte strojev in ne vozite avtomobila, če ste po jemanju zdravila Symtuza omotični.
English: Tell your doctor immediately about new or unusual symptoms after you stop treatment, particularly symptoms you associate with hepatitis B infection.
Slovenian: Po prenehanju zdravljenja takoj obvestite zdravnika o vsakem novem ali nenavadnem simptomu, zlasti če gre za simptome, ki so povezani z okužbo s hepatitisom B.
English: Mitochondrial dysfunction
Slovenian: Mitohondrijska disfunkcija
English: If you have both HIV infection and hepatitis B, it is very important not to stop taking Symtuza without talking to your doctor first.
Slovenian: Če ste okuženi tako z virusom HIV kot s hepatitisom B, je zelo pomembno, da ne prenehate z jemanjem zdravila Symtuza, ne da bi se prej posvetovali z zdravnikom.
English: It selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus infected cells, thereby preventing the formation of mature infectious virus particles.
Slovenian: Selektivno zavira cepljenje poliproteinov Gag-Pol, ki jih kodira virus HIV v z virusom okuženih celicah, in tako preprečuje nastajanje zrelih infektivnih virusnih delcev.
English: 6 cells/mm 3).
Slovenian: 6 celic/mm 3).
English: They either switched to Symtuza (N = 763) or continued their treatment regimen (N = 378) (randomised 2:1).
Slovenian: Bolniki so bodisi prešli na zdravljenje z zdravilom Symtuza (n = 763) ali nadaljevali s prejšnjim režimom zdravljenja (n = 378) (po randomizaciji v razmerju 2:1).
English: The safety and efficacy of Symtuza in children aged 3-11 years, or weighing < 40 kg, have not yet been established.
Slovenian: Varnost in učinkovitost zdravila Symtuza pri otrocih, starih od 3 do 11 let ali s telesno maso manj kot 40 kg, še nista bili dokazani.
English: • low red blood cell count (anaemia)
Slovenian: • zmanjšano število rdečih krvnih celic (anemija)
English: Based on theoretical considerations, no clinically relevant interaction is expected.
Slovenian: Glede na teoretična izhodišča ni pričakovati klinično pomembnih interakcij.
English: - Budesonide, fluticasone (to control asthma).
Slovenian: - budezonid, flutikazon (za nadzorovanje astme).
English: Voriconazole should not be combined with Symtuza unless an assessment of the benefit/risk ratio justifies the use of voriconazole.
Slovenian: Vorikonazola se ne sme uporabljati v kombinaciji z zdravilom Symtuza, razen če ocena razmerja med koristmi in tveganji upravičuje uporabo vorikonazola.
English: • If you have hepatitis B infection, your liver problems may become worse after you stop taking Symtuza.
Slovenian: • če imate okužbo z virusom hepatitisa B, se lahko težave z jetri poslabšajo, ko prenehate jemati zdravilo Symtuza.
English: The plastic bottle comes with a child resistant cap and must be opened as follows:
Slovenian: Plastenka ima za otroke varno zaporko, ki jo je treba odpreti takole:
English: This may be more likely with long-term HIV treatment, more severe damage to the immune system, being overweight, or the use of alcohol or medicines called corticosteroids.
Slovenian: Verjetnost za to je večja pri dolgotrajnejšem zdravljenju HIV, bolj okvarjenem imunskem sistemu, prekomerni telesni masi ali pri uživanju alkohola ali zdravil, ki jih imenujemo kortikosteroidi.
English: Daclatasvir Ledipasvir Sofosbuvir
Slovenian: daklatasvir ledipasvir sofosbuvir
English: There have been reports of mitochondrial dysfunction in HIV negative infants exposed in utero and/or postnatally to nucleoside analogues.
Slovenian: Obstajajo poročila o mitohondrijski disfunkciji pri HIV-negativnih dojenčkih, ki so bili in utero in/ali postnatalno izpostavljeni nukleozidnim analogom.
English: • symptoms of infection or of autoimmune disorders (immune reconstitution inflammatory syndrome)
Slovenian: • simptomi ok-užbe ali avtoimunskih bolezni (vnetni sindrom imunske obnove)
English: Sulphonamide allergy
Slovenian: Alergija na sulfonamide
English: Symtuza is not for use in children younger than 12 years, or weighing less than 40 kg, as it has not been studied in children under 12 years.
Slovenian: Zdravilo Symtuza ni namenjeno uporabi pri otrocih, ki so stari 12 let ali manj ali je njihova telesna masa manjša od 40 kg, saj uporabe pri otrocih, ki so stari manj kot 12 let, niso raziskali.
English: • if you have haemophilia.
Slovenian: • če imate hemofilijo.
English: 90 film-coated tablets (3 bottles containing 30 tablets each) The bottles are not to be distributed individually.
Slovenian: 90 filmsko obloženih tablet (3 plastenke po 30 tablet) Plastenk se ne sme izdajati posamezno.
English: Clinical monitoring is recommended, as maintenance therapy may need to be adjusted in some patients.
Slovenian: Zato je priporočljivo klinično spremljanje, saj bo pri nekaterih bolnikih verjetno treba prilagoditi vzdrževalni odmerek.
English: For the treatment of pulmonary arterial hypertension Sildenafil Tadalafil
Slovenian: Za zdravljenje pljučne arterijske hipertenzije sildenafil tadalafil
English: If appropriate, initiation of hepatitis B therapy may be warranted.
Slovenian: Lahko se uvede tudi zdravljenje hepatitisa B,če je primerno.
English: A long term carcinogenicity study in mice did not show any carcinogenic potential.
Slovenian: Dolgoročne študije kancerogenosti na miših pa niso pokazale kancerogenega potenciala.
English: What you need to know before you take Symtuza
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Symtuza
English: Your doctor will advise you how to deal with your symptoms or whether Symtuza must be stopped.
Slovenian: Zdravnik vam bo povedal, kako obvladovati simptome, ki jih imate, in ali je treba zdravljenje z zdravilom Symtuza prekiniti.
English: Changes in measures of renal function
Slovenian: Spremembe v meritvah ledvične funkcije
English: Haemophiliac patients should, therefore, be made aware of the possibility of increased bleeding.
Slovenian: Bolniki s hemofilijo se morajo zato zavedati možnosti zvečanih krvavitev.
English: At 48 weeks, 92% (46/50) achieved HIV-1 RNA < 50 copies/mL, similar to response rates in studies of treatment-naïve HIV-1 infected adults.
Slovenian: Po 48 tednih jih je 92% (46/50) doseglo vrednost HIV-1 RNK v plazmi < 50 kopij/ml, kar je podobna stopnja odziva kot v študijah s predhodno nezdravljenimi odraslimi bolniki z okužbo z virusom HIV-1.
English: Norethindrone drospirenone AUC ↑ 58% drospirenone Cmax ↑ 15% drospirenone Cmin ND
Slovenian: etinilestradiol noretindron drospirenon AUC ↑ 58% drospirenon Cmax ↑ 15% drospirenon Cmin ND
English: Rosuvastatin (10 mg once daily): rosuvastatin AUC ↑ 93% rosuvastatin Cmax ↑ 277% rosuvastatin Cmin ND
Slovenian: rosuvastatin (10 mg enkrat na dan): rosuvastatin AUC ↑ 93% rosuvastatin Cmax ↑ 277% rosuvastatin Cmin ND
English: Symtuza is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and adolescents (aged 12 years and older with body weight at least 40 kg).
Slovenian: Zdravilo Symtuza je indicirano za zdravljenje okužbe z virusom humane imunske pomanjkljivosti tipa 1 (HIV-1) pri odraslih in mladostnikih (starih 12 let ali več in s telesno maso najmanj 40 kg).
English: 95-1,110), and median CD4+ % was 23% (range: 7-45%).
Slovenian: 3 (od 95 do 1.110), mediani odstotek celic CD4+ pa je bil 23% (od 7 do 45%).
English: • if you notice any muscle or bone problems.
Slovenian: • če opazite težave z mišicami ali kostmi.
English: The biotransformation of emtricitabine includes oxidation of the thiol moiety to form the 3'-sulfoxide diastereomers (approximately 9% of dose) and conjugation with glucuronic acid to form 2'-O-glucuronide (approximately 4% of dose).
Slovenian: Biotransformacija emtricitabina vključuje oksidacijo tiolne skupine, pri čemer nastanejo 3'-sulfoksid diastereomere (približno 9% odmerka), in konjugacijo z glukuronsko kislino, pri čemer nastane 2'-O-glukuronid (približno 4% odmerka).
English: INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS Medicinal products by therapeutic areas
Slovenian: MEDSEBOJNA DELOVANJA Z DRUGIMI ZDRAVILI IN PRIPOROČILA ZA ODMERJANJE Učinkovine po terapevtskih področjih
English: simvastatin, lovastatin and lomitapide (see section 4.5) - dabigatran, ticagrelor
Slovenian: simvastatin, lovastatin in lomitapid (glejte poglavje 4.5) - dabigatran, tikagrelor
English: ANTIBIOTIC Clarithromycin
Slovenian: ANTIBIOTIKI klaritromicin
English: Patients were on a stable ARV regimen (for at least 6 months), consisting of a boosted protease inhibitor [either darunavir once daily or atazanavir (both boosted with ritonavir or cobicistat), or lopinavir with ritonavir] combined with emtricitabine and TDF.
Slovenian: Bolniki so bili na stabilnem protiretrovirusnem režimu (najmanj 6 mesecev), z uporabo okrepljenega zaviralca proteaze [bodisi darunavirja enkrat na dan ali atazanavirja (v obeh primerih okrepljenega z ritonavirjem ali s kobicistatom) ali lopinavirja z ritonavirjem] v kombinaciji z emtricitabinom in TDF.
English: The tablet should not be crushed.
Slovenian: Tablete se ne sme lomiti ali drobiti.
English: • Push the plastic screw cap down while turning it counter clockwise.
Slovenian: • Potisnite plastično navojno zaporko navzdol in jo pri tem obračajte v nasprotni smeri urinega kazalca.
English: Any inflammatory symptoms should be evaluated and treatment instituted when necessary.
Slovenian: Vse simptome vnetja je treba ovrednotiti in če je potrebno, uvesti primerno zdravljenje.
English: Rash was mostly mild to moderate, often occurring within the first four weeks of treatment and resolving with continued dosing (see section 4.4).
Slovenian: Izpuščaj je bil večinoma blag do zmeren, pogosto se je pojavil v prvih štirih tednih zdravljenja in ob nadaljevanju zdravljenja izzvenel (glejte poglavje 4.4).
English: Ex vivo rabbit studies and in vivo dog studies suggest that cobicistat has a low potential for QT prolongation, and may slightly prolong the PR interval and decrease left ventricular function at mean concentrations at least 10-fold higher than the human exposure at the recommended 150 mg daily dose.
Slovenian: Študije pri kuncih ex vivo in pri psih in vivo kažejo, da ima kobicistat majhen potencial za podaljšanje intervala QT in da lahko nekoliko podaljša interval PR ter zmanjša delovanje levega prekata pri povprečnih koncentracijah, ki so najmanj 10-krat višje od izpostavljenosti pri ljudeh pri uporabi priporočenega dnevnega odmerka 150 mg.
English: Virologic response was defined as a decrease in plasma HIV-1 RNA viral load of at least 1.0 log10 versus baseline (see Table 7).
Slovenian: Virološki odziv je bil opredeljen kot zmanjšanje virusnega bremena HIV-1 RNK v plazmi za najmanj 1,0 log10 v primerjavi z izhodiščno vrednostjo (glejte Preglednico 7).
English: Because of both the potential for HIV transmission and the potential for adverse reactions in breast-fed infants, mothers should be instructed not to breast-feed if they are receiving Symtuza.
Slovenian: Zaradi možnosti prenosa okužbe s HIV in možnosti za neželene učinke pri dojenih otrocih, je treba materam naročiti, naj ne dojijo, če prejemajo zdravilo Symtuza.
English: ANTIMALARIALS Artemether/Lumefantrine
Slovenian: ANTIMALARIKI artemeter/lumefantrin
English: The silica gel desiccant is contained in a separate sachet or canister and should not be swallowed.
Slovenian: Sušilno sredstvo iz silikagela je v posebni vrečki ali vsebniku in ga ne smete pogoltniti.
English: - Atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin (to lower cholesterol levels).
Slovenian: - atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin (za zniževanje holesterola).
English: Population pharmacokinetic analysis showed a slightly higher darunavir exposure (16.8%) in HIV-1 infected females compared to males.
Slovenian: Populacijska analiza farmakokinetike je pokazala nekoliko večjo izpostavljenost darunavirju (16,8%) pri ženskah, okuženih z virusom HIV, kot pri moških.
English: If you have chronic hepatitis B or C infection, your doctor should check your blood tests more often because you have an increased chance of developing liver problems.
Slovenian: Če imate kronično okužbo z virusom hepatitisa B ali C, vam bo zdravnik pogosteje opravljal krvne preiskave, ker pri vas obstaja povečano tveganje za nastanek težav z jetri.
English: You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
Slovenian: Med jemanjem tega zdravila še vedno lahko prenesete okužbo s HIV na druge, čeprav učinkovito protiretrovirusno zdravljenje to tveganje zmanjša.
English: • osteonecrosis (bone damage caused by loss of blood supply to the bone)
Slovenian: • osteonekroza (odmiranje kostnega tkiva kot posledica pomanjkanja oskrbe kosti s krvjo)
English: DRV = darunavir; FTC = emtricitabine; PDVF = protocol-defined virologic failure; PI = protease inhibitor; RAM = resistanceassociated mutation; TDF = tenofovir disoproxil fumarate; TAF = tenofovir alafenamide
Slovenian: DRV = darunavir; FTC = emtricitabin; PDVF = s protokolom opredeljen virološki neuspeh (protocol-defined virologic failure); PI = zaviralec proteaze (protease inhibitor); RAM = mutacija, ki omogoča odpornost (resistance-associated mutation); TDF = dizoproksiltenofovirijev fumarat (tenofovir disoproxil fumarate); TAF = alafenamidtenofovirat (tenofovir alafenamide)
English: It is recommended that women with HIV do not breast-feed their infants because of the possibility of the baby becoming infected with HIV through breast milk and because the medicine may affect the baby.
Slovenian: Ženskam, okuženim s HIV, dojenje odsvetujejo zaradi možnosti okužbe dojenčka s HIV preko mleka in zaradi morebitnih učinkov zdravila na vašega dojenčka.
English: Darunavir has no effect on fertility or early embryonic development and DRV shows no teratogenic potential, at exposure levels below those at the recommended clinical dose in humans.
Slovenian: Darunavir ne vpliva na plodnost ali zgodnji razvoj zarodka in ne kaže teratogenega potenciala pri izpostavljenosti odmerkom, manjšim od priporočenih pri ljudeh..
English: If you forget to take Symtuza It is important not to miss a dose of Symtuza.
Slovenian: Če ste pozabili vzeti zdravilo Symtuza Pomembno je, da ne pozabite vzeti odmerka zdravila Symtuza.
English: Do not use this medicine after 6 weeks of first opening the bottle.
Slovenian: Zdravilo porabite v 6 tednih od prvega odprtja plastenke.
English: Amiodarone Dronedarone Ivabradine Quinidine Ranolazine
Slovenian: amjodaron dronedaron ivabradin kinidin ranolazin
English: There are pharmacokinetic data for the (individual) components of Symtuza.
Slovenian: Na voljo so podatki o farmakokinetiki (posameznih) učinkovin zdravila Symtuza.
English: Studies in animals have demonstrated that darunavir, cobicistat and tenofovir are excreted in milk.
Slovenian: Študije na živalih so pokazale, da se darunavir, kobicistat in tenofovir izločajo v mleko.
English: Symtuza and artemether/lumefantrine can be used without dose adjustments; however, due to the increase in lumefantrine exposure, the combination should be used with caution.
Slovenian: Kombinacija zdravila Symtuza in učinkovini artemeter/lumefantrin se lahko uporablja brez prilagajanja odmerkov, vendar je zaradi povečane izpostavljenosti lumefantrinu, pri tej kombinaciji potrebna previdnost.
English: Do not combine Symtuza with any of the following medicines If you are taking any of these, ask your doctor about switching to another medicine.
Slovenian: Zdravila Symtuuza ne smete kombinirati z nobenim od naslednjih zdravil Če jemljete katero od naštetih zdravil, prosite zdravnika, naj vam predpiše drugo zdravilo.
English: Reduced susceptibility to emtricitabine is associated with M184V/I mutations in HIV-1 RT.
Slovenian: Zmanjšana občutljivost za emtricitabin je povezana z mutacijami M184V/I reverzne transkriptaze virusa HIV-1.