FrancophonIA/ELRC3.0 huggingface dataset:
English: The rate and extent of absorption of Twynsta are equivalent to the bioavailability of telmisartan and amlodipine when administered as individual tablets.
Danish: Absorptionshastighed og -grad for Twynsta er ækvivalent med telmisartans og amlodipins biotilgængelighed, når de gives som individuelle tabletter.
English: Patients treated with 10 mg amlodipine who experience any dose limiting adverse reactions such as oedema, may be switched to Twynsta 40 mg/5 mg once daily, reducing the dose of amlodipine without reducing the overall expected antihypertensive response.
Danish: Patienter i behandling med 10 mg amlodipin, som oplever en hvilken som helst dosisbegrænsende bivirkning såsom ødem, kan skiftes til Twynsta 40 mg/5 mg én gang dagligt og dermed få reduceret amlodipin-dosen, uden at det samlede forventede antihypertensive respons reduceres.
English: Patients with hepatic insufficiency have decreased clearance of amlodipine with resulting increase of approximately 40-60 % in AUC.
Danish: Clearance af amlodipin hos patienter med nedsat leverfunktion er nedsat, hvilket medfører en stigning i AUC på ca. 40-60 %.
English: Due to risk of hyperkalemia, it is recommended that the coadministration of calcium channel blockers such as amlodipine be avoided in patients susceptible to malignant hyperthermia and in the management of malignant hyperthermia.
Danish: På grund af risikoen for hyperkaliæmi anbefales det at undgå samtidig administration af calciumkanalblokkere, såsom amlodipin, hos patienter, der er modtagelige for malign hypertermi, og i behandlingen af malign hypertermi.
English: • in adult patients whose blood pressure is not controlled enough with amlodipine alone.
Danish: • hos voksne patienter, hvis blodtryk ikke er tilstrækkeligt kontrolleret med amlodipin alene
English: NSAIDs (i.e. acetylsalicylic acid at anti-inflammatory dosage regimens, COX-2 inhibitors and nonselective NSAIDs) may reduce the antihypertensive effect of angiotensin II receptor antagonists.
Danish: NSAID'er (dvs. acetylsalicylsyre ved antiinflammatoriske dosisregimener, COX-2-hæmmere og ikkeselektive NSAID'er) kan reducere den antihypertensive virkning af angiotensin II-receptorantagonister.
English: • Medicines used for HIV/AIDS (e.g. ritonavir) or for treatment of fungal infections (e.g.
Danish: • Lægemidler, der bruges til behandling af hiv/aids (f.eks. ritonavir) eller svampeinfektioner (f.eks.
English: Adverse reactions previously reported with one of the individual components (telmisartan or amlodipine) may be potential adverse reactions with Twynsta as well, even if not observed in clinical trials or during the post-marketing period.
Danish: Tidligere rapporterede bivirkninger for hvert af de aktive stoffer (telmisartan eller amlodipin) kan ligeledes være mulige bivirkninger ved Twynsta, selvom de ikke er observeret i kliniske studier eller efter markedsføring.
English: In case of surgery or anaesthesia, you should tell your doctor that you are taking Twynsta.
Danish: Hvis du skal opereres eller bedøves, skal du fortælle din læge, at du tager Twynsta.
English: heparin, immunosuppressives (e.g. cyclosporin or tacrolimus), and the antibiotic trimethoprim.
Danish: heparin, immunsupprimerende lægemidler (f.eks. ciclosporin eller tacrolimus) og det antibiotiske middel trimethoprim.
English: This is because grapefruit and grapefruit juice may lead to increased blood levels of the active ingredient amlodipine in some patients and may increase the blood pressure lowering effect of Twynsta.
Danish: Det skyldes, at grapefrugt og grapefrugtjuice kan medføre øgede blodkoncentrationer af det aktive stof amlodipin hos nogle patienter, hvilket kan øge den blodtrykssænkende virkning af Twynsta.
English: In animal studies, reproductive toxicity was observed at high doses (see section 5.3).
Danish: I dyreforsøg blev der observeret reproduktionstoksicitet ved høje doser (se pkt.
English: The reduction in diastolic blood pressure <90 mmHg was achieved in 71.6 %, 74.8 %, 82.1 %, 85.3 % of patients respectively.
Danish: Reduktion af det diastoliske blodtryk til < 90 mmHg sås hos henholdsvis 71,6 %, 74,8 %, 82,1 % 85,3 % af patienterne.
English: These changes, also a class effect of angiotensin converting enzyme inhibitors and other angiotensin II receptor antagonists, do not appear to have clinical significance.
Danish: Disse forandringer, som også udgør en klassevirkning af ACE-hæmmere og andre angiotensin IIreceptorantagonister, synes ikke at have klinisk betydning.
English: Rare malaise influenza-like illness
Danish: Sjældne utilpashed influenzalignende sygdom
English: Very rare extrapyramidal syndrome, hypertonia
Danish: Meget sjældne extrapyramidale syndromer, hypertoni
English: Concomitant use of amlodipine with strong or moderate CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) may give rise to significant increase in amlodipine exposure resulting in an increased risk of hypotension.
Danish: Anvendelse af amlodipin sammen med potente eller moderate CYP3A4-hæmmere (proteasehæmmere, azol-antimykotika, makrolider som erytromycin eller claritromycin, verapamil eller diltiazem) kan føre til en signifikant øget eksponering over for amlodipin, og føre til en forhøjet risiko for hypotension.
English: Co-administration of multiple doses of 10 mg of amlodipine with simvastatin 80 mg resulted in an increase in exposure to simvastatin up to 77 % compared to simvastatin alone.
Danish: Samtidig behandling med 80 mg simvastatin og gentagne doser med 10 mg amlodipin resulterede i en øget eksponering for simvastatin med op til 77 % sammenlignet med simvastatin alene.
English: In animals, lethal ventricular fibrillation and cardiovascular collapse are observed in association with hyperkalemia after administration of verapamil and intravenous dantrolene.
Danish: Hos dyr observeres der dødelig ventrikelflimmer og kardiovaskulært kollaps forbundet med hyperkaliæmi efter administration af verapamil og intravenøs dantrolen.
English: Blood and lymphatic system disorders: Uncommon anaemia
Danish: Blod og lymfesystemet: Ikke almindelige anæmi
English: Twynsta contains sorbitol This medicine contains 168.64 mg sorbitol in each tablet.
Danish: Twynsta indeholder sorbitol Dette lægemiddel indeholder 168,64 mg sorbitol pr. tablet.
English: Twynsta combines two antihypertensive compounds with complementary mechanisms to control blood pressure in patients with essential hypertension: an angiotensin II receptor antagonist, telmisartan, and a dihydropyridinic calcium channel blocker, amlodipine.
Danish: Twynsta kombinerer to antihypertensive stoffer med komplementære virkningsmekanismer, som kontrollerer blodtrykket hos patienter med essentiel hypertension: en angiotensin II-receptorantagonist, telmisartan, og en dihydropyridin-calciumantagonist, amlodipin.
English: Normal amlodipine dosage regimens are recommended in the elderly, but increase of dosage should take place with care (see section 4.4).
Danish: Normale amlodipin-dosisregimener anbefales til ældre, men dosis skal forhøjes med forsigtighed (se pkt.
English: The following side effects have been observed with the components telmisartan or amlodipine and may occur also with Twynsta:
Danish: Følgende bivirkninger er observeret med henholdsvis telmisartan og amlodipin taget alene og kan også forekomme med Twynsta:
English: Very rare vasculitis
Danish: Meget sjældne vaskulitis
English: • NSAIDs (non steroidal anti-inflammatory medicines, e.g. acetylsalicylic acid or ibuprofen),
Danish: • NSAID'er (nonsteroide antiinflammatoriske lægemidler, f.eks. acetylsalicylsyre eller ibuprofen),
English: Ear and labyrinth disorders Uncommon vertigo tinnitus
Danish: Øre og labyrint: Ikke almindelige vertigo tinnitus
English: • The other ingredients are colloidal anhydrous silica, brilliant blue FCF (E133), ferric oxide black (E172), ferric oxide yellow (E172), magnesium stearate, maize starch, meglumine, microcrystalline cellulose, povidone K25, pregelatinized starch prepared from maize starch, sodium hydroxide, sorbitol (E420).
Danish: - Øvrige indholdsstoffer: kolloid vandfri silica, brilliant blue FCF (E133), sort jernoxid (E172), gul jernoxid (E172), magnesiumstearat, majsstivelse, meglumin, mikrokrystallinsk cellulose, povidon K25, prægelatineret stivelse fremstillet af majsstivelse, natriumhydroxid, sorbitol (E420).
English: Amlodipine is extensively (approximatively 90 %) metabolised by the liver to inactive metabolites.
Danish: Amlodipin metaboliseres i vid udstrækning til inaktive metabolitter (ca. 90 %) i leveren.
English: Twynsta has not been studied in any patient population other than hypertension.
Danish: Twynsta er kun undersøgt i patientpopulationer med hypertension.
English: Telmisartan is characterised by biexponential decay pharmacokinetics with a terminal elimination halflife of >20 hours.
Danish: Telmisartan har en bieksponentiel faldende farmakokinetik med en terminal eliminationshalveringstid på >20 timer.
English: Rare thrombocytopenia, eosinophilia
Danish: Sjældne thrombocytopeni, eosinofili
English: Children and adolescents Twynsta is not recommended in children and adolescents up to the age of 18 years.
Danish: Børn og unge Behandling af børn og unge under 18 år med Twynsta frarådes.
English: Very rare angioedema, erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, photosensitivity
Danish: Meget sjældne angiødem, erythema multiforme, nældefeber, eksfoliativ dermatitis, Stevens-Johnson syndrom, lysfølsomhed
English: Very rare hyperglycaemia
Danish: Meget Sjældne hyperglykæmi
English: The safety of amlodipine in human pregnancy has not been established.
Danish: Amlodipins sikkerhed under graviditet hos mennesker er ikke klarlagt.
English: When telmisartan was co-administered with digoxin, median increases in digoxin peak plasma concentration (49 %) and in trough concentration (20 %) were observed.
Danish: Ved samtidig administration af telmisartan og digoxin sås stigning i medianværdien for digoxin-Cmax (49 %) og -Cmin (20 %).
English: Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin converting enzyme inhibitors, and with angiotensin II receptor antagonists, including telmisartan.
Danish: Der er rapporteret om reversibel forøgelse af serumlitiumkoncentrationer og toksicitet ved administration af litium samtidig med angiotensinkonverterende enzymhæmmere og med angiotensin IIreceptorantagonister, herunder telmisartan.
English: Two large randomised, controlled trials (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and VA NEPHRON-D (The Veterans Affairs Nephropathy in
Danish: Kombinationen af en ACE-hæmmer og en angiotensin II-receptorantagonist er undersøgt i to store randomiserede, kontrollerede studier (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) og VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)).
English: Very rare hepatitis, jaundice, hepatic enzyme elevations (mostly consistent with cholestasis)
Danish: Meget sjældne hepatitis, gulsot, forhøjede leverenzymtal (ofte som følge af cholestase)
English: In some patients with compromised renal function (e.g. dehydrated patients or elderly patients with compromised renal function), the co-administration of angiotensin II receptor antagonists and medicinal products that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Danish: Hos nogle patienter med kompromitteret nyrefunktion (f.eks. dehydrerede patienter eller ældre patienter med kompromitteret nyrefunktion) kan samtidig administration af angiotensin II-receptorantagonister og lægemidler, der hæmmer cyklooxygenase, resultere i yderligere forværring af nyrefunktionen, herunder muligvis akut nyresvigt, hvilket sædvanligvis er reversibelt.
English: As with other blood pressure lowering medicines, the effect of Twynsta may be reduced when you take NSAIDs (non steroidal anti-inflammatory medicines, e.g. acetylsalicylic acid or ibuprofen) or corticosteroids.
Danish: Som ved andre blodtrykssænkende lægemidler kan virkningen af Twynsta være nedsat, hvis du samtidig tager NSAID'er (nonsteroide antiinflammatoriske lægemidler, f.eks. acetylsalicylsyre eller ibuprofen) eller kortikosteroider.
English: Rare syncope, peripheral neuropathy, hypoaesthesia, dysgeusia, tremor
Danish: Sjældne synkope, perifer neuropati, hypæstesi, dysgeusi, tremor
English: Caution is advised when using telmisartan/amlodipine in such patients as amlodipine and telmisartan are not dialysable (see also section 4.4).
Danish: Der skal udvises forsigtighed ved brug af telmisartan/amlodipin til sådanne patienter, da amlodipin og telmisartan ikke kan fjernes ved dialyse (se også pkt.
English: PHARMACEUTICAL FORM AND CONTENTS Multipack comprising 4 packs, each containing 90 x 1 tablets
Danish: LÆGEMIDDELFORM OG INDHOLD (PAKNINGSSTØRRELSE) Del af en multipakning med 4 pakninger, hver med 90 x 1 tabletter
English: Very rare hypersensitivity
Danish: Meget sjældne overfølsomhed
English: • in adult patients who already receive telmisartan and amlodipine from separate tablets and who wish to take instead the same doses in one tablet for convenience.
Danish: • hos voksne patienter, der allerede får telmisartan og amlodipin fra 2 forskellige tabletter, og som ønsker at gøre behandlingen lettere ved i stedet at tage de samme doser i én tablet
English: Twynsta may increase the blood pressure lowering effect of other medicines used to treat high blood pressure or of medicines with blood pressure lowering potential (e.g. baclofen, amifostine, neuroleptics or antidepressants).
Danish: Twynsta kan øge den blodtrykssænkende virkning af andre lægemidler, der bruges til behandling af højt blodtryk, eller af lægemidler, der potentielt kan sænke blodtrykket (f.eks. baklofen, amifostin, antipsykotika eller antidepressiva).
English: Each tablet contains 168.64 mg sorbitol (E420).
Danish: Hver tablet indeholder 168,64 mg sorbitol (E420).
English: Colloidal anhydrous silica Brilliant blue FCF (E133) Ferric oxide black (E172) Ferric oxide yellow (E172) Magnesium stearate
Danish: Brilliant blue FCF (E133) Sort jernoxid (E172)
English: Very rare leukocytopenia, thrombocytopenia
Danish: Meget sjældne leukocytopeni, thrombocytopeni
English: If hypotension occurs with telmisartan/amlodipine, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline.
Danish: Ved hypotension i forbindelse med telmisartan/amlodipin bør patienten placeres i liggende stilling, og om nødvendigt gives intravenøs infusion af isotonisk saltvand.
English: Administration of Twynsta with grapefruit or grapefruit juice is not recommended since bioavailability may be increased in certain patients resulting in increased blood pressure lowering effects.
Danish: Administration af Twynsta sammen med grapefrugt eller grapefrugtjuice anbefales ikke da biotilgængeligheden kan øges hos visse patienter og resultere i en forstærket blodtrykssænkende virkning.
English: Aluminium/aluminium blisters (PA/Al/PVC/Al) in a carton containing 14, 28, 56, 98 tablets or aluminium/aluminium perforated unit dose blisters (PA/Al/PVC/Al) in a carton containing 30 x 1, 90 x 1 tablets and multipacks containing 360 (4 packs of 90 x 1) tablets.
Danish: Aluminium/aluminium-blisterkort (PA/Al/PVC/Al) i æske indeholdende 14, 28, 56, 98 tabletter, eller perforerede enkeltdosis-aluminium/aluminium-blisterkort (PA/Al/PVC/Al) i æske indeholdende 30 x 1, 90 x 1 tabletter, og multipakninger indeholdende 360 (4 pakninger med 90 x 1) tabletter.
English: These pharmacologically-mediated undesirable effects, known from preclinical studies with both angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists, were prevented by oral saline supplementation.
Danish: Disse farmakologiskmedierede uønskede virkninger, som er kendt fra prækliniske studier med både ACE-hæmmere og angiotensin II-receptorantagonister, blev forebygget ved peroralt saltvandstilskud.
English: In order to avoid toxicity of tacrolimus, administration of amlodipine in a patient treated with tacrolimus requires monitoring of tacrolimus blood levels and dose adjustment of tacrolimus when appropriate.
Danish: For at undgå toksicitet af tacrolimus er overvågning af tacrolimus blodkoncentrationer samt en justering af tacrolimus dosis, når det er relevant, påkrævet.
English: Each tablet contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free'.
Danish: Hver tablet indeholder mindre end 1 mmol (23 mg) natrium pr. tablet, dvs. de er i det væsentlige natrium-frie.
English: With concomitant use of mTOR inhibitors, amlodipine may increase exposure of mTOR inhibitors.
Danish: Med samtidig brug af mTOR-hæmmere kan amlodipin øge eksponeringen over for mTOR-hæmmere.
English: This medicine contains 337.28 mg sorbitol in each tablet.
Danish: Dette lægemiddel indeholder 337,28 mg sorbitol pr. tablet.
English: • Low blood pressure (hypotension), likely to occur if you are dehydrated (excessive loss of body water) or have salt deficiency due to diuretic therapy (‘water tablets'), low-salt diet, diarrhoea, or vomiting.
Danish: • Lavt blodtryk (hypotension), som kan opstå, hvis du er dehydreret (overdrevent væsketab fra kroppen) eller har saltmangel på grund af diuretikabehandling (”vanddrivende tabletter”),
English: Animal reproductive toxicity studies with telmisartan/amlodipine have not been performed.
Danish: Der er ikke udført undersøgelser af reproduktionstoksicitet i dyrestudier med telmisartan/amlodipin.
English: Twynsta contains sodium
Danish: Twynsta indeholder natrium
English: Very rare myocardial infarction, arrhythmia, ventricular tachycardia, atrial fibrillation
Danish: Meget sjældne myocardieinfarkt, arytmi, ventrikulær takykardi, atrieflimren
English: Rare visual disturbance
Danish: Sjældne synsforstyrrelser
English: Twynsta is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Danish: Din læge kan vælge en anden behandling til dig, hvis du ønsker at amme - især hvis dit barn er nyfødt eller født for tidligt.
English: Do not take Twynsta
Danish: Tag ikke Twynsta
English: Rare tachycardia
Danish: Sjældne takykardi
English: Consideration should be given for monitoring cyclosporine levels in renal transplant patients on amlodipine, and cyclosporine dose reductions should be made as necessary.
Danish: Overvågning af ciclosporinniveauerne i nyretransplanterede patienter behandlet med amlodipin, bør overvejes og cyclosporin dosis nedsættes.
English: Cardiac disorders Uncommon bradycardia, palpitations
Danish: Hjerte: Ikke almindelige bradykardi, palpitationer
English: The concomitant use of telmisartan/amlodipine with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and
Danish: Samtidig brug af telmisartan/amlodipin og lægemidler indeholdende aliskiren er kontraindiceret hos patienter med diabetes mellitus eller nedsat nyrefunktion (GFR < 60 ml/min/1,73 m2) (se pkt.
English: Each tablet contains 337.28 mg sorbitol (E420).
Danish: Hver tablet indeholder 337,28 mg sorbitol (E420).
English: Twynsta tablets contain two active substances called telmisartan and amlodipine.
Danish: Twynsta tabletter indeholder to aktive stoffer - telmisartan og amlodipin.
English: Patients receiving telmisartan and amlodipine from separate tablets can instead receive tablets of Twynsta containing the same component doses in one tablet once daily.
Danish: Patienter, der får telmisartan og amlodipin fra separate tabletter, kan i stedet én gang dagligt få Twynsta tabletter, der indeholder de samme aktive stoffer i én tablet.
English: Common side effects (may affect up to 1 in 10 people): Altered bowel habits, diarrhoea, constipation, visual disturbances, double vision, ankle swelling.
Danish: Almindelige bivirkninger (kan forekomme hos op til 1 ud af 10 brugere): Ændring i afføringsvaner, diarré, forstoppelse, synsforstyrrelser, dobbeltsyn, ankelhævelse.
English: If you forget to take Twynsta
Danish: Hvis du har glemt at tage Twynsta
English: Unstable angina pectoris, acute myocardial infarction There are no data to support the use of telmisartan/amlodipine in unstable angina pectoris and during or within one month of a myocardial infarction.
Danish: Der er ingen data, som understøtter anvendelsen af telmisartan/amlodipin ved ustabil angina pectoris eller under og inden for en måned efter myokardieinfarkt.
English: • Medicines used to alter the way your immune system works (e.g. sirolimus, temsirolimus and everolimus).
Danish: • Lægemidler, der anvendes til at ændre den måde, immunsystemet virker på (f.eks. sirolimus,
English: Other medicines and Twynsta
Danish: Brug af anden medicin sammen med Twynsta
English: Adult patients receiving telmisartan and amlodipine from separate tablets can instead receive tablets of Twynsta containing the same component doses.
Danish: Voksne patienter, der får telmisartan og amlodipin fra separate tabletter, kan i stedet få Twynsta tabletter, der indeholder de samme doser af de aktive stoffer.
English: Metabolism and nutrition disorders Uncommon hyperkalaemia
Danish: Metabolisme og ernæring: Ikke almindelige hyperkaliæmi
English: In an amlodipine long-term, placebo controlled study in patients with severe heart failure (NYHA class III and IV) the reported incidence of pulmonary oedema was higher in the amlodipine treated group than in the placebo group (see section 5.1).
Danish: I et langtids, placebokontrolleret studie med amlodipin hos patienter med svær hjerteinsufficiens (NYHA-klasse III og IV) var den rapporterede forekomst af pulmonært ødem højere i gruppen behandlet med amlodipin end i placebogruppen (se pkt.
English: Skin and subcutaneous tissue disorders Uncommon pruritus hyperhidrosis alopecia, purpura, skin discolouration, hyperhidrosis
Danish: Hud og subkutane væv: Ikke almindelige pruritus hyperhidrose alopeci, purpura, misfarvning af huden, hyperhidrose
English: Twynsta is contraindicated in patients with severe hepatic impairment (see section 4.3).
Danish: Twynsta er kontraindiceret til patienter med svært nedsat leverfunktion (se pkt.
English: In patients not controlled on amlodipine 5 mg the oedema rates were 4.4 % for 40 mg/5 mg and 80 mg/5 mg and 24.9 % for amlodipine 10 mg.
Danish: Hos patienter, der fik amlodipin 5 mg, og som ikke var kontrollerede, var ødemfrekvensen 4,4 % for 40 mg/5 mg og 80 mg/5 mg og 24,9 % for amlodipin 10 mg.
English: Immune system disorders: Rare hypersensitivity, anaphylactic reaction
Danish: Immunsystemet: Sjældne overfølsomhed, anafylaktisk reaktion
English: In an 8-week multicenter, randomised, double-blind, placebo-controlled, parallel group factorial study in 1461 patients with mild to severe hypertension (mean seated diastolic blood pressure ≥95 and ≤119 mmHg), treatment with each combination dose of Twynsta resulted in significantly greater diastolic and systolic blood pressure reductions and higher control rates compared to the respective monotherapy components.
Danish: I et 8-ugers randomiseret, dobbeltblindet, placebokontrolleret, faktuelt, parallelgruppe-, multicenterstudie med 1.461 patienter med let til svær hypertension (gennemsnitligt DBP siddende ≥95 og ≤119 mmHg) resulterede behandling med enhver Twynsta kombination i signifikant større reduktion af diastolisk og systolisk blodtryk og bedre blodtrykskontrol sammenlignet med monoterapi med de to aktive stoffer.
English: Uncommon arthralgia, muscle spasms (cramps in legs), myalgia
Danish: Ikke almindelige arthralgi, muskelspasmer (kramper i benene), myalgi
English: Infections and infestations Uncommon upper respiratory tract infection including pharyngitis and sinusitis, urinary tract infection including cystitis
Danish: Øvre luftvejsinfektion inklusiv halsbetændelse og bihulebetændelse, urinvejsinfektion inklusiv cystitis