FrancophonIA/ELRC3.0 huggingface dataset:
English: These events were mild to moderate in nature, none were reported as serious and were generally resolved while the patient continued treatment.
Slovenian: Ti učinki so bili blagi do zmerni, noben ni bil prijavljen kot resen in so na splošno minili med nadaljevanjem zdravljenja.
English: If normokalaemia is not achieved after 72 hours of treatment, other treatment approaches should be considered.
Slovenian: Če normokaliemija ni dosežena niti po 72 urah zdravljenja, je treba razmisliti o drugih načinih zdravljenja.
English: The adverse reactions identified from controlled trials are shown in Table 1.
Slovenian: Neželeni učinki, ugotovljeni v kontroliranih preskušanjih, so prikazani v Preglednici 1.
English: • Your doctor may decide that you need more (10 g once a day) or less than this (5 g every other day).
Slovenian: • Zdravnik se lahko odloči, da potrebujete več (10 g enkrat na dan) ali manj (5 g vsaki drugi dan) od tega.
English: Also, tell your doctor or nurse if you are taking any of the following:
Slovenian: Prav tako obvestite zdravnika ali medicinsko sestro, če jemljete katero od naslednjih zdravil:
English: • Rinse the glass with more water and drink it all up to take all the medicine.
Slovenian: • Splaknite kozarec z nekaj dodatne vode in to vodo popijte, da boste zaužili vse zdravilo.
English: The sachets are supplied in a carton containing 3, 28 or 30 sachets.
Slovenian: Vrečice so na voljo v škatlah, ki vsebujejo 3, 28 ali 30 vrečic.
English: Therefore, the subject was eligible for the Correction Phase ITT Population; however, the time point was excluded from the analysis.
Slovenian: Zato je bil sicer ustrezen za populacijo z namenom zdravljenja v obdobju korekcije, toda časovna točka je bila izključena iz analize.
English: If the powder settles, the water should be stirred again.
Slovenian: Če se prašek sesede, je treba vodo znova premešati.
English: Do not use this medicine after the expiry date which is stated on the carton and the sachet after ‘EXP'.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in vrečici poleg oznake "EXP".
English: Summary of the safety profile The most commonly reported adverse reactions were hypokalaemia (4.1%) and oedema related events
Slovenian: Povzetek varnostnih značilnosti Najpogosteje poročani neželeni učinki so bili hipokaliemija (4,1 %) in z edemi povezani dogodki
English: • you start to have a build up of fluid in the tissues, leading to swelling anywhere in your body (usually in the feet and ankles).
Slovenian: • če se vam začne kopičiti tekočina v tkivih; to povzroči otekanje kjer koli v telesu (običajno v stopalih ali gležnjih).
English: Typically, normokalaemia is achieved within 24 to 48 hours.
Slovenian: Praviloma je normokaliemija dosežena v 24 do 48 urah.
English: The entire contents of the sachet should be emptied in a drinking glass containing approximately 45 ml of water and stirred well.
Slovenian: Celotno vsebino vrečice je treba stresti v kozarec, v katerem je približno 45 ml vode in dobro premešati.
English: If patients are still hyperkalaemic after 48 hours of treatment, the same regimen can be continued for an additional 24 hours.
Slovenian: Če je bolnik tudi po 48 urah zdravljenja še vedno hiperkaliemičen, je treba enako shemo nadaljevati dodatnih 24 ur.
English: Long-term exposure Clinical trials with Lokelma have not included exposure longer than one year.
Slovenian: Dolgotrajna izpostavljenost Klinična preskušanja z zdravilom Lokelma niso obsegala izpostavljenosti, daljše od enega leta.
English: Long term exposure
Slovenian: Dolgotrajna izpostavljenost
English: The following convention was used for frequency of adverse reactions: Very common (≥ 1/10); Common (≥ 1/100 to < 1/10); Uncommon (≥ 1/1,000 to < 1/100); Rare (≥ 1/10,000 to < 1/1,000); Very rare (< 1/10,000), not known (cannot be estimated from the available data).
Slovenian: Pogostnost neželenih učinkov je razvrščena po naslednji konvenciji: zelo pogosti (≥ 1/10), pogosti (od ≥ 1/100 do < 1/10), občasni (od ≥ 1/1.000 do < 1/100), redki (od ≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: Median time to normokalaemia was 2.2 hours with 66% of patients achieving normokalaemia at 24 hours and 88% at 48 hours.
Slovenian: Mediani čas do normokaliemije je bil 2,2 ure; 66 % bolnikov je doseglo normokaliemijo v 24 urah in 88 % v 48 urah.
English: Tell your doctor or nurse if you experience any of the following: Common side effects (may affect up to 1 in 10 people).
Slovenian: Zdravniku ali medicinski sestri povejte, če se vam pojavi kaj od naslednjega: Pogosti neželeni učinki (pojavijo se lahko pri največ 1 od 10 bolnikov).
English: CP at 48 hours
Slovenian: FK po 48 urah
English: • The powder does not dissolve and the liquid appears cloudy.
Slovenian: • Prašek se ne raztopi in tekočina je motnega videza.
English: Lokelma is indicated for the treatment of hyperkalaemia in adult patients (see section 4.4 and 5.1).
Slovenian: Zdravilo Lokelma je indicirano za zdravljenje hiperkaliemije pri odraslih bolnikih (glejte poglavji 4.4 in 5.1).
English: 5 or 10 g of powder in sachets made of a PET/alu/LLDPE or PET/LDPE/alu/EAA/LLDPE laminate
Slovenian: 5 ali 10 g praška v vrečicah, narejenih iz PET/aluminij/LLDPE ali PET/LDPE/aluminij/EEA/LLDPE laminata.
English: The suspension can be taken with or without food.
Slovenian: Suspenzijo lahko bolnik popije s hrano ali brez nje.
English: Pack sizes: 3, 28 or 30 sachets
Slovenian: Velikosti pakiranj: 3, 28 ali 30 vrečic.
English: Do not take Lokelma • If you are allergic to the active substance.
Slovenian: Ne jemljite zdravila Lokelma: • Če ste alergični na učinkovino.
English: Maintenance (day)
Slovenian: Vzdrževanje (dan)
English: Lokelma 10 g three times daily (N=749)
Slovenian: Zdravilo Lokelma 10 g trikrat na dan (N = 749)
English: All three studies tested the initial effect of Lokelma to correct hyperkalaemia during a 48-hour period and two studies also tested maintenance of normokalaemia effect obtained.
Slovenian: Vse tri študije so preverjale začetni učinek zdravila Lokelma na odpravo hiperkaliemije v 48-urnem obdobju, dve študiji pa sta preverjali tudi vzdrževanje doseženega normokaliemičnega učinka.
English: What Lokelma is and what it is used for
Slovenian: Kaj je zdravilo Lokelma in za kaj ga uporabljamo
English: • you have sudden or severe pain in your abdomen as this may be a sign of a problem that is observed with other medications that work in the gastrointestinal tract.
Slovenian: • če imate nenadne ali hude bolečine v trebuhu; to je lahko znak težave, opažene med uporabo drugih zdravil, ki delujejo v prebavilih.
English: CP at 24 hours
Slovenian: FK po 24 urah
English: 1.25 g three times daily
Slovenian: 1,25 g trikrat na dan
English: Do not take any more until you have spoken to a doctor.
Slovenian: Zdravila ne vzemite več, dokler se ne posvetujete z zdravnikom.
English: • Stir well and drink the tasteless liquid straight away.
Slovenian: • Dobro premešajte in tekočino, ki je brez okusa, takoj popijte.
English: When normokalaemia is achieved, the maintenance regimen should be followed (see below).
Slovenian: Ko je dosežena normokaliemija, je treba upoštevati shemo za vzdrževalno zdravljenje (glejte spodaj).
English: • Do not take a maintenance dose of more than 10 g once a day.
Slovenian: • Ne jemljite vzdrževalnega odmerka, večjega od 10 g enkrat na dan.
English: Note: One subject had a post-dose value that was more than 1 day after last dose.
Slovenian: Opomba: En preiskovanec je imel evidentirano vrednost po odmerku več kot 1 dan po zadnjem odmerku.
English: If the patient is having abdominal X-rays, radiographers should keep this in mind.
Slovenian: Če mora bolnik opraviti rentgensko slikanje trebuha, mora radiolog upoštevati to dejstvo.
English: This is because the effects of Lokelma in children and adolescents are not known.
Slovenian: Učinki zdravila Lokelma pri otrocih in mladostnikih namreč niso znani.
English: Pharmacotherapeutic group: Drugs for treatment of hyperkalaemia and hyperphosphatemia, ATC code: V03AE10
Slovenian: Farmakoterapevtska skupina: zdravila za zdravljenje hiperkaliemije in hiperfosfatemije, Oznaka ATC: V03AE10
English: When normokalaemia has been achieved, the minimal effective dose of Lokelma to prevent recurrence of hyperkalaemia should be established.
Slovenian: Ko je normokaliemija dosežena je treba uvesti najmanjši učinkoviti odmerek zdravila Lokelma za preprečevanje ponovne hiperkaliemije.
English: What you need to know before you take Lokelma
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Lokelma
English: Correction (hour)
Slovenian: Korekcija (ura)
English: Maintenance phase
Slovenian: Obdobje vzdrževanja
English: • angiotensin converting enzyme (ACE) inhibitors such as enalapril, and angiotensin receptor blockers which name ends with sartan (medicines for high blood pressure and for heart problems)
Slovenian: • zaviralci angiotenzinske konvertaze (ACE), na primer enalapril in blokatorji receptorjev angiotenzina, katerih ime se končuje na "sartan" (zdravila za visok krvni tlak in za težave s srcem)
English: There are no other ingredients in this medicine.
Slovenian: To zdravilo ne vsebuje drugih sestavin.
English: The safety profile of Lokelma was evaluated in clinical trials involving 1760 patients with 507 patients exposed for one year.
Slovenian: Varnostne značilnosti zdravila Lokelma so ocenili v kliničnih preskušanjih, ki so zajela 1760 bolnikov; 507 bolnikov je bilo izpostavljenih eno leto.
English: Hypokalaemia
Slovenian: Hipokaliemija
English: These five studies included 1760 patients given doses of Lokelma; 507 exposed for at least 360 days.
Slovenian: Teh pet študij je zajelo 1760 bolnikov, ki so dobivali odmerke zdravila Lokelma; 507 bolnikov je bilo zdravilu izpostavljenih vsaj 360 dni.
English: Correction Phase (CP)
Slovenian: Faza korekcije (FK)
English: No statistically significant changes in urinary sodium excretion were observed.
Slovenian: Statistično značilnih sprememb v izločanju natrija v urinu niso ugotovili.
English: The events were observed in the maintenance phase only and were more commonly seen in patients treated with 15 g. Up to 53% were managed by initiating a diuretic or adjusting a diuretic dose; the remainder did not require treatment.
Slovenian: Te učinke so opažali le v vzdrževalni fazi in so bili pogostejši pri bolnikih, zdravljenih s 15 g. Do 53 % je bilo obvladanih z uvedbo diuretika ali prilagoditvijo odmerka diuretika; preostali niso potrebovali zdravljenja.
English: Due to the open label study design, a causal relationship between these events and Lokelma cannot be definitively established.
Slovenian: Zaradi odprtega načrta te študije ni mogoče dokončno ugotoviti vzročne povezanosti med temi učinki in zdravilom Lokelma.
English: • you start to feel tired, or have muscle weakness or cramps, this may be a sign that your blood potassium has become too low.
Slovenian: • če se začnete počutiti utrujene ali če občutite šibkost mišic ali krče - to so lahko znaki prenizkega kalija v krvi.
English: Reductions in potassium were observed 1 hour after the first 10 g dose of Lokelma.
Slovenian: Znižanje kalija so opazili 1 uro po prvem 10 g odmerku zdravila Lokelma.
English: In an environment where other factors affecting renin and aldosterone were not controlled, Lokelma demonstrated a dose-independent change in mean serum aldosterone levels (range: -30% to -31%) compared with the placebo group (+14%).
Slovenian: V okolju, kjer niso bili kontrolirani drugi dejavniki, ki vplivajo na renin in aldosteron, je zdravilo Lokelma doseglo od odmerka neodvisno spremembo povprečne koncentracije aldosterona v serumu (razpon: -30 % do -31 %), v primerjavi s placebom (+14 %).
English: During the correction phase, 10 g of Lokelma was administered three times daily for at least 24 hours and up to 72 hours.
Slovenian: Med fazo korekcije so 10 g zdravila Lokelma uporabljali trikrat na dan vsaj 24 ur in do 72 ur.
English: • renin inhibitors such as aliskiren (for high blood pressure)
Slovenian: • zaviralci renina kot je aliskiren (za visok krvni tlak).
English: Maintenance phase with Lokelma titration (open-label) results: 123 patients entered the 11-month open-label phase.
Slovenian: Rezultati (odprtega) obdobja vzdrževanja s titriranjem zdravila Lokelma: 123 bolnikov je vstopilo v 11-mesečno odprto obdobje podaljšanja.
English: Days
Slovenian: Dnevi
English: Oedema related events
Slovenian: Z edemi povezani dogodki
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Lokelma in one or more subsets of the paediatric population in male and female children from birth to less than 18 years of age, with hyperkalaemia (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Lokelma za eno ali več podskupin pediatrične populacije pri dečkih in deklicah od rojstva do manj kot 18. leta starosti pri hiperkaliemiji (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Hyperkalaemia means that there is a high level of potassium in the blood.
Slovenian: Hiperkaliemija pomeni visoko koncentracijo kalija v krvi.
English: Monitoring frequency will depend upon a variety of factors including other medications, progression of chronic kidney disease and dietary potassium intake.
Slovenian: Pogostnost kontrol je odvisna od različnih dejavnikov, med drugim od uporabe drugih zdravil, napredovanja kronične ledvične bolezni in prehranskega vnosa kalija.
English: List of adverse reactions in clinical studies System Organ class
Slovenian: Preglednica 1: Seznam neželenih učinkov v kliničnih študijah Organski sistem
English: Lokelma lowers the high levels of potassium in your body and helps to keep it at a normal level.
Slovenian: Zdravilo Lokelma znižuje visoko koncentracijo kalija v telesu in jo pomaga vzdrževati v normalnem območju.
English: The tasteless liquid should be drunk while still cloudy.
Slovenian: Tekočino, ki je brez okusa, je treba popiti, dokler je še motna.
English: Exit=Last Visit within 1 day of Last Dose, EOS=End of Study (7 days +/- 1 day after Last Dose) *Given three times daily
Slovenian: Izhod = zadnji obisk v okviru 1 dne po zadnjem odmerku, KŠ = konec študije (7 dni +/- 1 dan po zadnjem odmerku) *Uporabljeno trikrat na dan.
English: The primary endpoint was the rate of change in serum potassium from baseline throughout the initial 2 days of treatment.
Slovenian: Primarni opazovani dogodek je bil delež spremembe kalija v serumu od izhodišča v uvodnih 2 dnevih zdravljenja.
English: Monitoring
Slovenian: Nadzor
English: No more than 10 g once daily should be used for maintenance therapy.
Slovenian: Za vzdrževalno zdravljenje se ne sme uporabljati več kot 10 g zdravila enkrat na dan.
English: Lokelma is used to treat hyperkalaemia in adults.
Slovenian: Zdravilo Lokelma se uporablja za zdravljenje hiperkaliemije pri odraslih.
English: Detailed information on this medicine is also available on the European Medicines Agency web site: http://www.ema.europa.eu
Slovenian: Podrobne informacije o zdravilu so objavljene tudi na spletni strani Evropske agencije za zdravila: http://www.ema.europa.eu.
English: Exit EOS
Slovenian: Izhod KŠ
English: The risk for intestinal perforation with the use of Lokelma is currently unknown.
Slovenian: Tveganje za predrtje črevesa med uporabo zdravila Lokelma trenutno ni znano.
English: Serum potassium should be monitored periodically and the Lokelma dose titrated as described in section 4.2 Posology and Method of Administration.
Slovenian: Kalij v serumu je treba redno kontrolirati in odmerek zdravila Lokelma titrirati, kot je opisano v poglavju 4.2, Odmerjanje in način uporabe.
English: • ketokonazole, itraconazole and posaconazole (used to treat fungal infections)
Slovenian: • ketokonazol, itrakonazol ali posakonazol (uporabljajo se za zdravljenje glivičnih okužb)
English: Since intestinal perforation has been reported with polymers that act in the gastrointestinal tract, specific attention should be paid to signs and symptoms related to intestinal perforation.
Slovenian: Ker pa je bilo predrtje črevesa opisano pri polimerih, ki delujejo v prebavilih, je treba posebno pozornost nameniti znakom in simptomom,
English: 2.5 g three times daily 5 g three times daily 10 g three times daily NS: not significant
Slovenian: 2,5 g trikrat na dan 5 g trikrat na dan 10 g trikrat na dan NZ: neznačilno
English: Among those patients using RAAS inhibitors at baseline, 89% did not discontinue RAAS inhibitor therapy, 74% were able to maintain the same dose during the maintenance phase and among those not on RAAS inhibitors at baseline, 14% were able to initiate this therapy.
Slovenian: Med bolniki, ki so izhodiščno uporabljali zaviralce RAAS, jih 89 % ni prenehalo jemati zaviralce RAAS, 74 % jih je lahko med obdobjem vzdrževanja ohranilo enak odmerek; med tistimi, ki izhodiščno niso prejemali zaviralcev RAAS, jih je to zdravljenje lahko začelo 14 %.
English: The dose may be raised or lowered based on your blood potassium level.
Slovenian: Odmerek je mogoče na podlagi koncentracije kalija v krvi povečati ali zmanjšati.
English: The potassium-lowering effects of Lokelma have been demonstrated in three randomised, double-blind, placebo-controlled trials in patients with hyperkalaemia.
Slovenian: Učinek zdravila Lokelma na znižanje kalija so dokazali tudi v treh randomiziranih, dvojno slepih, s placebom kontroliranih preskušanjih pri bolnikih s hiperkaliemijo.
English: n/N Proportion 95% CI
Slovenian: 95 % IZ n/N Delež
English: During maintenance phase, 75.6% of subjects maintained normokalaemia, despite use of RAAS inhibitors.
Slovenian: Med obdobjem vzdrževanja se je normokaliemija kljub uporabi zaviralcev RAAS ohranila pri 75,6 % preiskovancev.
English: Hypersensitivity to the active substance.
Slovenian: Preobčutljivost na učinkovino.
English: • If you forget to take a dose of this medicine, skip the missed dose.
Slovenian: • Če ste pozabili vzeti odmerek zdravila, izpuščeni odmerek preskočite.
English: • you start to have itching of the skin or recognise redness or scaling of your skin.
Slovenian: • če se vam pojavi srbenje kože ali opazite pordelost ali luščenje kože.
English: At the end of the maintenance period, when Lokelma was no longer administered, average potassium levels increased to near baseline levels.
Slovenian: Na koncu obdobja vzdrževanja, ko zdravila Lokelma niso več uporabljali, se je povprečna koncentracija kalija znova zvišala skoraj na izhodiščno raven.
English: There are no data from the use of sodium zirconium cyclosilicate in pregnant women.
Slovenian: Podatkov o uporabi natrijevega cirkonijevega ciklosilikata pri nosečnicah ni.
English: Powder for oral suspension.
Slovenian: prašek za peroralno suspenzijo
English: Subjects who achieved normokalaemia (3.5-5.0 mmol/L, inclusive) within 72 hours entered the maintenance phase of the study.
Slovenian: Preiskovanci, ki so v 72 urah dosegli normokaliemijo (3,5-5,0 mmol/l, vključno), so vstopili v vzdrževalno fazo študije.
English: Sodium zirconium cyclosilicate starts reducing serum potassium concentrations as soon as 1 hour after ingestion and normokalaemia can be achieved typically within 24 to 48 hours.
Slovenian: Natrijev cirkonijev ciklosilikat začne zniževati koncentracijo kalija v serumu že 1 uro po zaužitju in normokaliemija je praviloma lahko dosežena v 24 do 48 urah.
English: • Open the sachet and pour the powder into a drinking glass with approximately 45 ml of still
Slovenian: • Odprite vrečico in vsujte prašek v kozarec, v katerem je približno 45 ml navadne (negazirane)
English: 28 sachets
Slovenian: 28 vrečic
English: As a precautionary measure, it is preferable to avoid the use of Lokelma during pregnancy.
Slovenian: Zaradi previdnosti se je uporabi zdravila Lokelma med nosečnostjo bolje izogibati.
English: Your doctor or nurse will check your blood potassium level when you start taking this medicine:
Slovenian: Zdravnik ali medicinska sestra vam bosta ob začetku jemanja tega zdravila kontrolirala koncentracijo kalija v krvi:
English: In the studies, Lokelma reduced serum potassium and maintained normal serum potassium levels regardless of the underlying cause of hyperkalaemia, age, sex, race, comorbid disease or concomitant use of RAAS inhibitors.
Slovenian: V teh študijah je zdravilo Lokelma znižalo kalij v serumu in ohranilo normalno koncentracijo kalija v serumu ne glede na osnovni vzrok hiperkaliemije, starost, spol, raso, sočasne bolezni ali sočasno uporabo zaviralcev RAAS.
English: Serum potassium should be monitored when clinically indicated, including after changes are made to medicinal products that affect the serum potassium concentration (e.g. renin-angiotensin-aldosterone system (RAAS) inhibitors or diuretics) and after the Lokelma dose is titrated.
Slovenian: Koncentracijo kalija v serumu je treba kontrolirati, če je to klinično indicirano, med drugim po spremembi zdravil, ki vplivajo na koncentracijo kalija v serumu (npr. zaviralci sistema reninangiotenzin-aldosteron (RAAS) in diuretiki) in po titriranju odmerka zdravila Lokelma.
English: Serum potassium should be checked and potassium supplemented as needed.
Slovenian: Kalij v serumu je treba kontrolirati in dodajati kalij, kot je potrebno.
English: Patients on dialysis
Slovenian: Bolniki na dializi
English: In a study of healthy subjects given Lokelma 5 g or 10 g once daily for four days, dosedependent reduction in serum potassium concentration and total urinary potassium excretion were accompanied by mean increases in faecal potassium excretion.
Slovenian: V študiji zdravih oseb, ki so štiri dni prejemale 5 g ali 10 g zdravila Lokelma enkrat na dan, je od odmerka odvisno znižanje koncentracije kalija v serumu in zmanjšanje celotnega izločanja kalija v urinu spremljalo povprečno povečanje izločanja kalija v blatu.
English: Driving and using machines This medicine has no or negligible influence on your ability to drive or to use machines.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev To zdravilo nima vpliva ali ima zanemarljiv vpliv na sposobnost upravljanja vozil in strojev.
English: No dose adjustments or separation of time of dosing are required for any of these medicinal products.
Slovenian: Odmerka nobenega od teh zdravil ni treba prilagoditi, prav tako ni potreben ločen čas uporabe.
English: Lokelma has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Lokelma nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: • The recommended dose is 5 g taken once a day.
Slovenian: • Priporočeni odmerek je 5 g enkrat na dan.
English: Sodium zirconium cyclosilicate is highly selective for potassium ions, even in the presence of other cations, such as calcium and magnesium, in vitro.
Slovenian: Natrijev cirkonijev ciklosilikat je in vitro visoko selektiven za kalijeve ione, celo v prisotnosti drugih kationov, na primer kalcija in magnezija.
English: What Lokelma is and what it is used for What you need to know before you take Lokelma How to take Lokelma
Slovenian: Kaj je zdravilo Lokelma in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Lokelma Kako jemati zdravilo Lokelma Možni neželeni učinki
English: Kaplan-Meier estimates of time to relapse for maintenance phase showed dose dependence in time to relapse with median time for 5 g dose ranging from 4 to 21 days depending on the baseline serum potassium values.
Slovenian: Kaplan-Meierjeve ocene časa do ponovitve za fazo vzdrževanja so pokazale, da je čas do ponovitve odvisen od odmerka; s srednjim časom v razponu od 4 do 21 dni za 5 g odmerek, odvisno od izhodiščne vrednosti kalija v serumu.