FrancophonIA/ELRC3.0 huggingface dataset:
English: Adverse reactions were reported in approximately 4 % of adults treated with 40 mg aprepitant compared with approximately 6 % of patients treated with 4 mg ondansetron intravenously.
Slovenian: O neželenih učinkih so poročali pri približno 4 % odraslih, ki so se zdravili z aprepitantom v odmerku 40 mg in pri približno 6 % bolnikov, ki so se zdravili z ondansetronom v odmerku 4 mg intravensko.
English: No clinically important effect resulted on Day 4 (midazolam AUC0-∞ 1.2-fold increase) and a slight change in midazolam AUC0-∞ was observed on Day 8 (35 % decrease).
Slovenian: 4. dan ni bilo nobenega klinično pomembnega učinka (1,2-kratno povečanje vrednosti AUC0- midazolama), 8. dan pa so opazili rahlo spremembo vrednosti AUC0- midazolama (35 % zmanjšanje).
English: Do not give EMEND powder for oral suspension to children under 6 months of age or who weigh less than 6 kg, or to adolescents between 12 and 18 years, because the powder for oral suspension has not been studied in this population.
Slovenian: Zdravila EMEND prašek za peroralno suspenzijo ne dajajte otrokom, mlajšim od 6 mesecev ali s telesno maso manj kot 6 kg, in prav tako ne mladostnikom, starim od 12 do 18 let, ker prašek za peroralno suspenzijo pri tej populaciji ni bil raziskan.
English: *The confidence intervals were calculated with no adjustment for gender and region, which were included in the primary analysis using logistic models.
Slovenian: *Intervali zaupanja so bili izračunani brez prilagoditve na spol ali področje, ki sta bila vključena v primarno analizo z uporabo logističnih modelov.
English: The content of each single-use sachet is to be suspended in 4.6 mL of water giving a final concentration of 25 mg per mL.
Slovenian: Vsebino ene vrečke za enkratno uporabo je treba suspendirati v 4,6 ml vode, da je končna koncentracija 25 mg na ml.
English: Complete response (no emesis and no rescue therapy) Overall (0-120 hours)
Slovenian: Popoln odziv (brez bruhanja in brez rešilnega zdravljenja) Skupaj (0-120 ur)
English: Figure 2 Time to first vomiting episode from start of chemotherapy administration - paediatric patients in the overall phase-Cycle 1 (Intent to treat population)
Slovenian: Slika 2 Čas do prvega bruhanja od začetka dajanja kemoterapije - pediatrični bolniki v celotni fazi - 1. ciklus (populacija z-namenom-zdravljenja)
English: When you have finished do not throw away any medicines via wastewater or household waste.
Slovenian: Ko ste končali, zdravila ne smete odvreči v odpadne vode ali med gospodinjske odpadke.
English: For information regarding birth control, see ‘Other medicines and EMEND'.
Slovenian: Za podatke glede kontracepcije glejte poglavje "Druga zdravila in zdravilo EMEND".
English: In controlled clinical studies in adults receiving general anaesthesia, 564 patients were administered 40 mg aprepitant orally and 538 patients were administered 4 mg ondansetron intravenously.
Slovenian: V nadzorovanih kliničnih študijah pri odraslih s splošno anestezijo je 564 bolnikov prejelo aprepitant v odmerku 40 mg peroralno, 538 bolnikov pa ondansetron v odmerku 4 mg intravensko.
English: Gender: Following oral administration of a single 125 mg dose of aprepitant, the Cmax for aprepitant is 16 % higher in females as compared with males.
Slovenian: Spol: Po enem peroralnem odmerku 125 mg aprepitanta je Cmax aprepitanta pri ženskah za 16 % višja kot pri moških.
English: No significant nausea (maximum VAS < 25 mm on a scale of 0-100 mm) Overall (0-120 hours)
Slovenian: Brez pomembne navzee (največja ocena < 25 mm na vizualni analogni lestvici 0-100 mm) Skupaj (0-120 ur)
English: WHEN: Take one EMEND 80 mg capsule each morning on the next two days.
Slovenian: KDAJ: V naslednjih 2 dneh vzemite eno EMEND 80 mg kapsulo zjutraj.
English: This combination (i.e. EMEND, ondansetron and dexamethasone) decreased the AUC of oral midazolam 16 % on Day 6, 9 % on Day 8, 7 % on Day 15 and 17 % on Day 22.
Slovenian: Ta kombinacija (to je zdravilo EMEND, ondansetron in deksametazon) je zmanjšala AUC peroralnega midazolama 6. dan za 16 %, 8. dan za 9 %, 15. dan za 7 % in 22. dan za 17 %.
English: If you have taken too many capsules, contact your doctor immediately.
Slovenian: Če ste vzeli preveč kapsul, se nemudoma posvetujte z zdravnikom.
English: The safety and efficacy of EMEND powder for oral suspension in infants below 6 months of age or weighing less than 6 kg has not been established.
Slovenian: Varnost in učinkovitost zdravila EMEND prašek za peroralno suspenzijo pri dojenčkih, mlajših od 6 mesecev ali s telesno maso manj kot 6 kg, nista bili dokazani.
English: The Cmax was 10 % higher on Day 1 and 24 % higher on Day 5 in elderly relative to younger adults.
Slovenian: Cmax je bila pri starejših preiskovancih 1. dan za 10 % višja, 5. dan pa za 24 % višja kot pri mlajših odraslih preiskovancih.
English: The estimated time to first emesis in the combined analysis is depicted by the Kaplan-Meier plot in Figure 1.
Slovenian: Oceno časa do prvega bruhanja v kombinirani analizi prikazuje Kaplan-Meierjeva krivulja na sliki 1.
English: Fill the oral dispenser with the prescribed dose from the mixing cup according to the table below.
Slovenian: Odmernik napolnite s predpisanim odmerkom iz čaše za mešanje glede na spodnjo preglednico.
English: Tell the doctor if you or the child is taking these medicines since the treatment must be modified before you or the child start taking EMEND.
Slovenian: Obvestite zdravnika, če vi ali otrok jemljete katerega od teh zdravil, ker je zdravljenje treba prilagoditi, preden vi ali otrok začnete jemati zdravilo EMEND.
English: Oral administration of the capsule with a standard light breakfast and a high-fat breakfast resulted in an up to an 8 % and a 47 % increase in AUC0-∞ of aprepitant, respectively.
Slovenian: Po peroralni aplikaciji kapsule skupaj s standardnim lahkim zajtrkom oz. z zajtrkom z visoko vsebnostjo maščob je prišlo do 8 % oz. 47 % povečanja vrednosti AUC0- aprepitanta.
English: This is because their treatment will need to be changed before starting EMEND: - pimozide - for mental health problems - terfenadine and astemizole - for hay fever and other allergies - cisapride - for problems with digestion
Slovenian: Otrokovo zdravljenje bo namreč treba pred začetkom uporabe zdravila EMEND prilagoditi: - pimozid - za težave z duševnim zdravjem - terfenadin in astemizol - za seneni nahod in druge alergije - cisaprid - za zdravljenje prebavnih težav
English: Highly Emetogenic Chemotherapy Regimen Day 1
Slovenian: Zelo emetogena kemoterapija 1. dan
English: In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 and potentially with minor contribution by CYP1A2 and CYP2C19.
Slovenian: Študije in vitro s humanimi jetrnimi mikrosomi kažejo, da se aprepitant presnavlja predvsem s CYP3A4 in morda z manjšim prispevkom CYP1A2 in CYP2C19.
English: % (95 % CI)
Slovenian: % (95 % IZ)
English: Given the short duration of increased exposure, dose reduction of the immunosuppressant based on Therapeutic Dose Monitoring is not recommended on the day of and the day after administration of EMEND 165 mg.
Slovenian: Zaradi kratkega trajanja povečane izpostavljenosti zmanjšanja odmerka imunosupresivov na podlagi spremljanja terapevtskih odmerkov (Therapeutic Dose Monitoring) na dan uporabe zdravila EMEND 165 mg in dan po njej ne priporočamo.
English: Aprepitant is also an inducer of CYP2C9.
Slovenian: Aprepitant je tudi induktor CYP2C9.
English: Aprepitant is a selective high-affinity antagonist at human substance P neurokinin 1 (NK1) receptors.
Slovenian: Aprepitant je selektivni antagonist z visoko afiniteto na humanih receptorjih za substanco P nevrokinin 1 (NK1).
English: If you or the child has taken too many capsules, contact your doctor immediately.
Slovenian: Če ste vi ali otrok vzeli preveč kapsul, se nemudoma posvetujte z zdravnikom.
English: Table 4 Number (%) of paediatric patients with complete response and no vomiting by treatment group and phase - Cycle 1 (Intent to treat population)
Slovenian: Preglednica 4 Število (%) pediatričnih bolnikov s popolnim odzivom in brez bruhanja po zdravljenih skupinah in fazi - 1. ciklus (populacija z-namenom-zdravljenja)
English: EMEND is administered orally 1 hour prior to chemotherapy on Days 1, 2 and 3.
Slovenian: Zdravilo EMEND se uporablja peroralno 1 uro pred kemoterapijo 1., 2. in 3. dan.
English: Given the short duration of the 3-day regimen and the time-dependent limited changes in exposure, dose reduction of the immunosuppressant is not recommended during the 3 days of co-administration with EMEND.
Slovenian: Zaradi kratkega 3-dnevnega režima in časovno odvisnih manjših sprememb izpostavljenosti zmanjšanja odmerka imunosupresivov med 3-dnevno sočasno uporabo z zdravilom EMEND ne priporočamo.
English: Using a highly specific NK1-receptor tracer, positron emission tomography (PET) studies in healthy young men have shown that aprepitant penetrates into the brain and occupies NK1 receptors in a doseand plasma-concentration-dependent manner.
Slovenian: S študijami pozitronske emisijske tomografije (PET) pri zdravih mladih moških so z uporabo visoko specifičnega označevalca receptorjev NK1 ugotovili, da aprepitant prodre v možgane in zasede receptorje NK1, pri čemer je stopnja zasedenosti odvisna od odmerka in plazemske koncentracije.
English: % 95 % C.I.
Slovenian: % 95 % IZ
English: The mean absolute oral bioavailability of aprepitant is 67 % for the 80 mg capsule and 59 % for the 125 mg capsule.
Slovenian: Povprečna absolutna biološka uporabnost po peroralnem zaužitju 80 mg kapsule aprepitanta je 67 %, pri 125 mg kapsuli pa 59 %.
English: Moderately Emetogenic Chemotherapy Regimen Day 1
Slovenian: Zmerno emetogena kemoterapija 1. dan
English: EMEND 125 mg/80 mg is given as part of combination therapy (see section 4.2).
Slovenian: Zdravilo EMEND 125 mg/80 mg se daje v sklopu kombiniranega zdravljenja (glejte poglavje 4.2).
English: It can also be stored refrigerated (between 2°C and 8°C) for up to 72 hours.
Slovenian: Shranjuje se lahko tudi v hladilniku (med 2 °C in 8 °C) do 72 ur.
English: No dose reduction was required for paediatric patients receiving the control regimen.
Slovenian: Pediatričnim bolnikom, ki so prejemali kontrolno shemo, odmerka ni bilo treba zmanjšati.
English: Based on interaction studies with tolbutamide and oral contraceptives, total exposure of concomitantly administered active substances metabolised by CYP2C9 or CYP3A4 may be reduced up to 15-30 %.
Slovenian: Na podlagi študij interakcij s tolbutamidom in peroralnimi kontraceptivi se lahko celokupna izpostavljenost sočasno uporabljenim zdravilnim učinkovinam, ki se presnavljajo s CYP2C9 ali CYP3A4, zmanjša za do
English: Side effects for which the frequency is not known: - Stevens-Johnson syndrome/toxic epidermal necrolysis (rare severe skin reaction).
Slovenian: Neželeni učinki z neznano pogostnostjo so: - Stevens-Johnsonov sindrom/toksična epidermalna nekroliza (redka huda kožna reakcija)
English: One patient in the Aprepitant regimen only had data in the acute phase and was excluded from the overall and delayed phase analyses; one patient in the Standard regimen only had data in the delayed phase and was excluded from the overall and acute phase analyses.
Slovenian: Za enega bolnika, ki je prejemal aprepitant, so na voljo le podatki iz akutne faze zdravljenja in je bil izključen iz celotne analize in analize podaljšane faze; za enega bolnika, ki je prejemal običajno zdravljenje, so na voljo le podatki iz podaljšane faze in je bil izključen iz celotne analize in analize akutne faze.
English: - if the child is using ‘cisapride' - (for problems with digestion).
Slovenian: - če otrok uporablja cisaprid - (za zdravljenje prebavnih težav).
English: Your doctor will ask you to continue taking other medicines including a corticosteroid (such as dexamethasone) and a ‘5HT3 antagonist' (such as ondansetron) for preventing nausea and vomiting the following three days.
Slovenian: Zdravnik vam bo naročil, da nadaljujete z jemanjem drugih zdravil, vključno s kortikosteroidom (kot je deksametazon) in zaviralcem 5HT3 (kot je ondasetron) za preprečevanje navzee in bruhanja še naslednje tri dni.
English: In healthy young adults, the increase in AUC0- was 26 % greater than dose proportional between 80 mg and 125 mg single doses administered in the fed state.
Slovenian: Pri zdravih mladih odraslih je bilo povečanje AUC0- za 26 % višje od razmerja odmerkov med posameznima 80 mg in 125 mg odmerkoma, ki so ju preiskovanci prejeli siti.
English: - with medicines containing pimozide (used to treat psychiatric illnesses), terfenadine and astemizole (used for hay fever and other allergic conditions), cisapride (used for treating digestive problems).
Slovenian: - skupaj z zdravili, ki vsebujejo pimozid (ki se uporablja za zdravljenje psihiatričnih bolezni), terfenadin ali astemizol (ki se uporabljata za zdravljenje senenega nahoda in drugih alergij) ali cisaprid (ki se uporablja za zdravljenje prebavnih težav).
English: The mixture will be cloudy pink to light pink.
Slovenian: Mešanica bo motna in rožnata do svetlorožnata.
English: Each sachet of EMEND for oral suspension contains 125 mg of aprepitant which is to be suspended in 4.6 mL of water giving a final concentration of 25 mg/mL.
Slovenian: Ena vrečka zdravila EMEND za peroralno suspenzijo vsebuje 125 mg aprepitanta, ki ga je potrebno suspendirati v 4,6 ml vode, da je končna koncentracija 25 mg/ml.
English: In 2 multicentre, randomised, double-blind, active comparator-controlled, parallel-group phase III clinical studies in adults, aprepitant was compared with ondansetron for the prevention of PONV in 1,658 patients undergoing open abdominal surgery.
Slovenian: V 2 multicentričnih, randomiziranih, dvojno slepih, s primerjalno zdravilno učinkovino nadzorovanih kliničnih študijah vzporednih skupin III. faze pri odraslih, so pri preprečevanju PONV aprepitant primerjali z ondansetronom pri 1.658 bolnikih z operacijo na odprti trebušni votlini.
English: EMEND should be used with caution in these patients (see section 5.2).
Slovenian: Pri teh bolnikih je treba zdravilo EMEND uporabljati previdno (glejte poglavje 5.2).
English: Aprepitant (125 mg/80 mg) is a substrate, a moderate inhibitor, and an inducer of CYP3A4.
Slovenian: Aprepitant (125 mg/80 mg) je substrat, zmerni zaviralec in induktor CYP3A4.
English: The AUC0-∞ of aprepitant following oral administration of 165 mg was equivalent to the AUC0-∞ of 150 mg fosaprepitant administered intravenously, while the Cmax was 2.4-fold lower.
Slovenian: Vrednost AUC0- aprepitanta po peroralni aplikaciji 165 mg odmerka je bila ekvivalentna vrednosti AUC0- 150 mg fosaprepitanta, apliciranega intravensko, Cmax pa je bila 2,4-krat nižja.
English: Studies evaluating the use of aprepitant in paediatric patients are on-going (see section 4.2 for information on paediatric use).
Slovenian: Študije za ovrednotenje uporabe aprepitanta pri pediatričnih bolnikih so v teku (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: If any of the above apply to the child (or you are not sure), talk to the doctor, pharmacist or nurse before giving this medicine.
Slovenian: Če kar koli od naštetega velja za otroka (ali če ste negotovi), se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro, preden daste to zdravilo.
English: Concomitant intake of a 40 mg dose with a standard breakfast decreased the aprepitant Cmax by 18 % but did not affect AUC.
Slovenian: Pri jemanju 40 mg odmerka skupaj z običajnim zajtrkom se zmanjša le Cmax aprepitanta za 18 %, vrednost AUC pa se ne spremeni.
English: A summary of the primary and secondary endpoints is shown in Table 4.
Slovenian: Povzetek primarnih in sekundarnih opazovanih dogodkov je prikazan v preglednici 4.
English: The potential for effects of aprepitant on fertility has not been fully characterised because exposure levels above the therapeutic exposure in humans could not be attained in animal studies.
Slovenian: Možnost vpliva aprepitanta na plodnost ni v celoti raziskana, saj med študijami na živalih niso mogli doseči ravni izpostavljenosti, ki bi bila višja od terapevtske izpostavljenosti pri človeku.
English: In a randomised, double-blind, active comparator-controlled clinical study that included 302 children and adolescents (aged 6 months to 17 years) receiving moderately or highly emetogenic chemotherapy, the aprepitant regimen was compared to a control regimen for the prevention of CINV.
Slovenian: V randomizirani, dvojno slepi, s primerjalno zdravilno učinkovino nadzorovani klinični študiji, ki je vključevala 302 otrok in mladostnikov (starih od 6 mesecev do 17 let), ki so prejemali zmerno ali zelo emetogeno kemoterapijo, so primerjali shemo z aprepitantom in kontrolno shemo za preprečevanje navzee in bruhanja zaradi kemoterapije (CINV).
English: An additional study was completed with intravenous administration of midazolam and EMEND.
Slovenian: Dokončana je bila tudi dodatna študija, v kateri so bolniki prejeli midazolam intravensko in zdravilo EMEND.
English: Start on the day after your chemotherapy.
Slovenian: Z zdravljenjem začnite dan po kemoterapiji.
English: Take the EMEND capsule on the first day of your chemotherapy cycle, together with other medicines, to prevent nausea and vomiting.
Slovenian: Vzemite kapsulo zdravila EMEND 1. dan kemoterapije skupaj z drugimi zdravili za preprečevanje navzee in bruhanja.
English: The median peak plasma concentration (Cmax) was approximately 1.3 µg/mL on Day 1, occurring at approximately 4 hours.
Slovenian: Mediana najvišja koncentracija v plazmi (Cmax) je bila 1. dan približno 1,3 µg/ml in je bila dosežena po približno 4 urah.
English: In patients with severe renal impairment, the AUC0- of total aprepitant (unbound and protein bound) decreased by 21 % and Cmax decreased by 32 %, relative to healthy subjects.
Slovenian: Pri bolnikih s hudo okvaro ledvic je bila vrednost AUC0- celokupnega aprepitanta (nevezanega in vezanega na beljakovine) za 21 % manjša, Cmax pa je bila za 32 % nižja kot pri zdravih preiskovancih.
English: Aprepitant does not seem to interact with the P-glycoprotein transporter, as suggested by the lack of interaction of aprepitant with digoxin.
Slovenian: Kaže, da aprepitant ne vstopa v interakcije z digoksinom, kar nakazuje, da nima interakcij s P-glikoproteinskim prenašalcem.
English: 1 hard capsule 6 x 1 hard capsule
Slovenian: 1 trda kapsula 6 x 1 trda kapsula
English: A PET study in healthy young men administered a single oral dose of 165 mg aprepitant or a single intravenous dose of 150 mg fosaprepitant demonstrated similar brain NK1 receptor occupancy at Tmax, (≥ 99 %), 24 hours (≥ 99 %), 48 hours (≥ 97 %), and 120 hours (37 to 76 %) following dosing.
Slovenian: Študija PET pri zdravih mladih moških, ki so prejeli enkratni peroralni 165 mg odmerek aprepitanta ali enkratni intravenski 150 mg odmerek fosaprepitanta, je pokazala podobno zasedenost možganskih receptorjev NK1 ob času tmax (≥ 99 %), 24 ur (≥ 99 %), 48 ur (≥ 97 %) in 120 ur (37 do 76 %) po odmerjanju.
English: In patients with ESRD undergoing haemodialysis, the AUC0- of total aprepitant decreased by 42 % and Cmax decreased by 32 %.
Slovenian: Pri bolnikih s končno odpovedjo ledvic na hemodializi je bila vrednost AUC0- celokupnega aprepitanta za 42 % manjša, Cmax pa je bila za 32 % nižja.
English: - birth control medicines which can include birth control pills, skin patches, implants, and certain Intrauterine devices (IUDs) that release hormones may not work adequately when taken together with EMEND.
Slovenian: - Zanesljivost kontracepcijskih zdravil, vključno s kontracepcijskimi tabletkami, obliži, vsadki in določenimi materničnimi vložki (IUD), ki sproščajo hormone, se lahko pri jemanju skupaj z zdravilom EMEND zmanjša.
English: Discard any remaining suspension and waste material.
Slovenian: Zavrzite preostalo suspenzijo in odpadni material.
English: Take the capsule 1 hour before you start your chemotherapy session.
Slovenian: Kapsulo vzemite 1 uro pred začetkom vaše kemoterapije.
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkanjem saharoza-izomaltaze ne smejo jemati tega zdravila.
English: Musculoskeletal and connective tissue disorders muscular weakness, muscle spasms rare
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva mišična oslabelost, mišični spazmi redki
English: Table 1 Percent of post-operative adults responding by treatment group Combined results from 2 Phase III trials
Slovenian: Preglednica 1 Odstotek odraslih z odzivom po operaciji glede na skupino zdravljenja Kombinirani rezultati iz 2 preskušanj faze III
English: The pharmacokinetics of aprepitant is non-linear across the clinical dose range.
Slovenian: Farmakokinetika aprepitanta je v območju kliničnih odmerkov nelinearna.
English: Following a single oral dose of aprepitant 165 mg to healthy volunteers, the mean AUC0-∞ of aprepitant was 32.5 µg•hr/mL and the mean maximal aprepitant concentration was 1.67 µg/mL.
Slovenian: Po enkratnem peroralnem 165 mg odmerku aprepitanta je bila pri zdravih prostovoljcih povprečna vrednost AUC0- aprepitanta 32,5 µg•hr/ml, povprečna najvišja koncentracija aprepitanta pa 1,67 µg/ml.
English: As nausea and vomiting may occur in the days following your chemotherapy, it is important that you take EMEND for 2 consecutive days as prescribed by your doctor.
Slovenian: Ker se v dneh po kemoterapiji lahko pojavita navzea (siljenje na bruhanje) in bruhanje, je pomembno, da zdravilo EMEND jemljete dva dni zapored, kot vam je predpisal zdravnik.
English: As nausea and vomiting may occur in the days following your chemotherapy, it is important that you take EMEND for 3 consecutive days as prescribed by your doctor.
Slovenian: Ker se v dneh po kemoterapiji lahko pojavita navzea (siljenje na bruhanje) in bruhanje, je pomembno, da zdravilo EMEND jemljete tri dni zapored, kot vam je predpisal zdravnik.
English: The 3-day oral aprepitant regimen resulted in an about 30-35 % reduction in AUC of CYP2C9 substrates and up to a 64 % decrease in ethinyl estradiol trough concentrations.
Slovenian: Pri uporabi 3-dnevne sheme s peroralnim aprepitantom je prišlo do približno 30-35 % zmanjšanja vrednosti AUC substratov CYP2C9 in do 64 % znižanja najmanjše koncentracije etinilestradiola.
English: The median peak plasma concentration (Cmax) was approximately 1.2 µg/mL on Day 1, occurring between 5 and 7 hours.
Slovenian: Mediana najvišja koncentracija v plazmi (Cmax) je bila 1. dan približno 1,2 µg/ml in je bila dosežena po 5 do 7 urah.
English: EMEND works by blocking signals to that area, thereby reducing nausea and vomiting.
Slovenian: Zdravilo EMEND deluje tako, da blokira signale v to področje, s čimer se zmanjšata navzea in bruhanje.
English: 3 mg/kg orally Maximum dose 125 mg
Slovenian: 3 mg/kg peroralno največji odmerek 125 mg
English: Further studies evaluating the use of aprepitant in paediatric patients are on-going (see section 4.2 for information on paediatric use).
Slovenian: V teku so nadaljnje študije za ovrednotenje uporabe aprepitanta pri pediatričnih bolnikih (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Administer the dose orally.
Slovenian: Odmerek uporabite peroralno.
English: In the same 2 clinical studies, 851 adult patients continued into the Multiple-Cycle extension for up to 5 additional cycles of chemotherapy.
Slovenian: 851 odraslih bolnikov iz teh dveh kliničnih študij je zdravljenje nadaljevalo v podaljšku z več ciklusi, in sicer do 5 dodatnih ciklusov kemoterapije.
English: During treatment with EMEND, CYP3A4 is inhibited for up to 4 days.
Slovenian: Med zdravljenjem z zdravilom EMEND je CYP3A4 inhibiran do 4 dni.