FrancophonIA/ELRC3.0 huggingface dataset:
English: This leads to a high level of sugar (glucose) in your blood.
Slovenian: To povzroči visoko koncentracijo sladkorja (glukoze) v krvi.
English: Periodic safety update reports (PSURs)
Slovenian: • Redno posodobljena poročila o varnosti zdravila (PSUR)
English: The numerical imbalance of breast, bladder, and prostate tumours must be considered with caution; it will be further investigated in post-authorisation studies.
Slovenian: Številsko neravnovesje pri tumorjih dojke, sečnega mehurja in prostate je treba tolmačiti previdno; to bo dodatno raziskano v študijah po izdaji dovoljenja za promet z zdravilom.
English: Occasionally, the inactive ingredients of this medicine will be eliminated in the faeces as a soft, hydrated mass that may resemble the original tablet.
Slovenian: Včasih se lahko neaktivne sestavine tega zdravila izločijo v blatu kot mehka, hidrirana masa, ki je lahko podobna originalni tableti.
English: Swallow the tablets whole with half a glass of water.
Slovenian: Jemanje tega zdravila - Tablete zaužijte cele s pol kozarca vode.
English: o film-coating:
Slovenian: o Filmska obloga:
English: Generally, the most common adverse events reported in ≥ 65 years old were similar to < 65 years old.
Slovenian: Na splošno so bili najpogostejši neželeni učinki, ki so bili zabeleženi pri osebah, starih ≥ 65 let, podobni kot pri osebah, starih < 65 let.
English: Saxagliptin: Elderly patients (65-80 years) had about 60% higher saxagliptin AUC than young patients (18-40 years).
Slovenian: Saksagliptin: Starejši bolniki (65-80 let) so imeli vrednost AUC saksagliptina približno 60 % večjo kot mladi bolniki (18-40 let).
English: The mean Vd ranged between 63-276 L.
Slovenian: Povprečni Vd je od 63 do 276 l.
English: The remaining 219 patients started to take 5 mg saxagliptin 16 weeks ahead of the study start.
Slovenian: Preostalih 219 bolnikov je začelo jemati 5 mg saksagliptina 16 tednov pred začetkom študije.
English: The dose should be taken as two tablets orally, once daily at the same time of the day, with food.
Slovenian: Odmerek morajo vzeti kot dve tableti, peroralno, enkrat na dan in vedno ob istem dnevnem času, skupaj s hrano.
English: A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital malformations.
Slovenian: Maloštevilni podatki o uporabi metformina pri nosečnicah ne kažejo večjega tveganja za prirojene malformacije.
English: Proportion of patients achieving HbA1c < 7%
Slovenian: Delež bolnikov, ki so dosegli HbA1c < 7 %
English: Talk to your doctor about the best way to control your blood sugar while you are pregnant.
Slovenian: Posvetujte se z zdravnikom o tem, kako najbolje uravnavati krvni sladkor med nosečnostjo.
English: Frequency categories were defined according to very common (≥ 1/10), common (≥ 1/100 to ˂ 1/10), uncommon (≥ 1/1,000 to ˂ 1/100), rare ( 1/10,000 to < 1/1,000), very rare ( 1/100,000 to < 1/10,000) and not known (cannot be estimated from the available data).
Slovenian: Kategorije pogostnosti so bile opredeljene kot: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki ( 1/10.000 do < 1/1.000), zelo redki ( 1/10.000 do < 1/10.000), neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov).
English: What Qtrilmet is and what it is used for
Slovenian: Kaj je zdravilo Qtrilmet in za kaj ga uporabljamo
English: Your doctor may prescribe other medicines to lower the amount of sugar in your blood.
Slovenian: Zdravnik vam lahko predpiše še druga zdravila za znižanje sladkorja v krvi.
English: The majority of patients in this study had a baseline HbA1c of > 8% (see Table 4).
Slovenian: Večina bolnikov v tej študiji je imela izhodiščni HbA1c > 8 % (glejte preglednico 4).
English: Difference in HbA1c effect
Slovenian: Razlika v učinku na HbA1c
English: Use in patients at risk for volume depletion, hypotension, and/or electrolyte imbalances
Slovenian: Uporaba pri bolnikih s tveganjem za zmanjšanje volumna, hipotenzijo in/ali neravnovesje elektrolitov
English: In patients at increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3-6 months.
Slovenian: Bolnikom, pri katerih obstaja večje tveganje za nadaljnje napredovanje okvare ledvic, in pri starejših je treba delovanje ledvic oceniti pogosteje, npr. na 3 do 6 mesecev.
English: Frequencies of all uncommon adverse reactions were based on the individual mono-components data.
Slovenian: Pogostnosti vseh občasnih neželenih učinkov temeljijo na podatkih o posameznih učinkovinah.
English: Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption which may very rarely result in clinically significant vitamin B12 deficiency.
Slovenian: Dolgotrajno zdravljenje z metforminom je bilo povezano z zmanjšanjem absorpcije vitamina B12; to lahko zelo redko povzroči klinično pomembno pomanjkanje vitamina B12.
English: Qtrilmet is not recommended for children and adolescents under 18 years of age because it has not been studied in these patients.
Slovenian: Uporaba zdravila Qtrilmet ni priporočljiva pri otrocih in mladostnikih, starih manj kot 18 let, ker pri teh bolnikih zdravilo ni raziskano.
English: Mean absolute lymphocyte counts remained stable with daily dosing up to 102 weeks in duration.
Slovenian: Povprečno absolutno število limfocitov je ostalo stabilno med vsakodnevno uporabo do 102 tedna.
English: Qtrilmet should not be used during pregnancy.
Slovenian: Zdravila Qtrilmet se med nosečnostjo ne sme uporabljati.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Qtrilmet in all subsets of the paediatric population in the treatment of type 2 diabetes (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij z zdravilom Qtrilmet za vse podskupine pediatrične populacije za zdravljenje sladkorne bolezni tipa 2 (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: The majority of events were considered non-serious, mild or moderate in intensity, and resolved.
Slovenian: Večina učinkov ni bila resnih, so bili blagi ali zmerni in so izzveneli.
English: Interaction studies have been performed with the individual active substances of Qtrilmet.
Slovenian: Študije medsebojnih delovanj so izvedli s posameznimi učinkovinami zdravila Qtrilmet.
English: Because elderly patients (≥ 65 years) are more likely to have decreased renal function, this medicinal product should be used with caution as age increases.
Slovenian: Ker je pri starejših bolnikih (≥ 65 let) verjetnost za zmanjšano delovanje ledvic večja, je treba to zdravilo z naraščajočo starostjo uporabljati previdno.
English: This medicine is for a type of diabetes called “type 2 diabetes”.
Slovenian: To zdravilo je namenjeno za zdravljenje vrste sladkorne bolezni, imenovane “sladkorna bolezen tipa 2”.
English: When driving or using machines, it should be taken into account that dizziness has been reported in studies with saxagliptin.
Slovenian: Pri vožnji ali upravljanju strojev je treba upoštevati, da je bila v študijah s saksagliptinom opisana omotica.
English: The AUC values of 5-OH-saxagliptin were also increased.
Slovenian: Večja je bila tudi vrednost AUC 5-OH-saksagliptina.
English: Do not use this medicine after the expiry date, which is stated on the blister and carton after ‘EXP'.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu in škatli poleg oznake ‘EXP'.
English: p-value < 0.0001. p-value = 0.0166.
Slovenian: Vrednost p = 0,0166.
English: If no adequate strength of Qtrilmet is available, individual mono-components should be used instead of the modified-release combination.
Slovenian: Če ni na voljo ustrezne jakosti zdravila Qtrilmet, je treba namesto kombinacije s prirejenim sproščanjem uporabiti posamezne sestavine ločeno.
English: Combinations requiring precautions for use
Slovenian: Kombinacije, ki zahtevajo previdnost
English: The volume of distribution of saxagliptin was 205 L.
Slovenian: Volumen porazdelitve saksagliptina je 205 l.
English: Treatment should be interrupted in patients who are hospitalised for major surgical procedures or acute serious medical illnesses.
Slovenian: Zdravljenje je treba prekiniti pri bolnikih, sprejetih v bolnišnico za večje operacije ali zaradi akutnih resnih internističnih bolezni.
English: The three medicines in Qtrilmet lower the amount of sugar in the blood by causing it to be taken up into cells or passed out of the body in the urine.
Slovenian: Tri zdravila v zdravilu Qtrilmet zmanjšajo količino sladkorja v krvi; to dosežejo tako, da ali povzročijo njegovo vstopanje v celice ali njegovo izločanje iz telesa z urinom.
English: The increases in creatinine were generally transient during continuous treatment or reversible after discontinuation of treatment.
Slovenian: Zvišanja kreatinina so bila med nadaljevanjem zdravljenjem na splošno prehodna oziroma po prenehanju zdravljenja reverzibilna.
English: Due to the limited therapeutic experience with this medicinal product in patients 75 years and older, initiation of therapy is not recommended in this population.
Slovenian: Zaradi omejenih terapevtskih izkušenj s tem zdravilom pri bolnikih, starih 75 let ali več, uvedba zdravljenja pri tej skupini bolnikov ni priporočljiva.
English: Patients with signs and symptoms of urinary tract infections should be evaluated and promptly treated, if indicated.
Slovenian: Bolnike z znaki in simptomi okužbe sečil je treba ovrednotiti in jih nemudoma zdraviti, če je indicirano.
English: Patients and/or care-givers should be informed on the risk of lactic acidosis.
Slovenian: Bolnike in/ali njihove skrbnike je treba opozoriti na tveganje laktacidoze.
English: Organic cation transporters (OCT) Metformin is a substrate of both transporters OCT1 and OCT2.
Slovenian: Prenašalci organskih kationov (OCT - Organic cation transporters) Metformin je substrat prenašalcev OCT1 in OCT2.
English: Do not stop taking Qtrilmet without talking to your doctor first.
Slovenian: Ne prenehajte jemati zdravila Qtrilmet, ne da bi se prej posvetovali z zdravnikom.
English: Metformin: The available data in subjects with moderate renal insufficiency are scarce and no reliable estimation of the systemic exposure to metformin in this subgroup as compared to subjects with normal renal function could be made.
Slovenian: Metformin: Podatkov pri osebah z zmerno insuficienco ledvic je malo in tako ni bilo mogoče zanesljivo oceniti sistemske izpostavljenosti metforminu v tej podskupini v primerjavi z osebami z normalnim delovanjem ledvic.
English: When the patient plans to become pregnant, and during pregnancy, it is recommended that diabetes is not treated with this medicinal product, but insulin be used to maintain blood glucose levels as close to normal as possible, to reduce the risk of malformations of the foetus associated with abnormal blood glucose levels.
Slovenian: Ko bolnica načrtuje nosečnost in med nosečnostjo, je priporočljivo, da se za zdravljenje sladkorne bolezni ne uporablja tega zdravila, temveč insulin, da bi vzdrževali koncentracijo glukoze v krvi čim bližje normalni in tako zmanjšali tveganje za malformacije ploda, povezane z nenormalno koncentracijo glukoze v krvi.
English: To control your diabetes, you need to follow your doctor's advice on diet and exercise, even when you are taking this medicine.
Slovenian: Za obvladovanje sladkorne bolezni morate upoštevati zdravnikova navodila glede diete in telesne dejavnosti, tudi če jemljete to zdravilo.
English: Your doctor may prescribe a medicine to treat your allergic reaction and change your diabetes medicine.
Slovenian: Zdravnik vam bo morda predpisal zdravilo za zdravljenje alergijske reakcije in zamenjal zdravilo za sladkorno bolezen.
English: HbA1c change from baseline at week 24 excluding data after rescue for randomised subjects - studies MB102129 and CV181168
Slovenian: Sprememba HbA1c od izhodišča do 24. tedna, izključujoč podatke pri randomiziranih preiskovancih, pri katerih so uporabili rešilne ukrepe - študiji MB102129 in CV181168
English: n = number of subjects with non-missing baseline and a week 24 value.
Slovenian: n = število preiskovancev, pri katerih ni bilo manjkajočih vrednosti, ne izhodiščne, ne po 24 tednih.
English: Use of alternative methods to monitor glycaemic control is advised.
Slovenian: Priporoča se uporaba drugih metod za nadziranje urejenosti glikemije.
English: Qtrilmet has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Qtrilmet nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: Onset of symptoms following initiation of therapy may be rapid or may occur after longer periods of treatment.
Slovenian: Simptomi se lahko pojavijo kmalu po začetku zdravljenja ali po daljšem obdobju zdravljenja.
English: oedema peripheral
Slovenian: periferni edemi
English: Lactic acidosis Vitamin B12 deficiency
Slovenian: laktacidoza pomanjkan je vitamina B12
English: Additional safety data include clinical trials, post-authorisation safety studies and post-marketing experience with the mono-components.
Slovenian: Dodatni podatki o varnosti izvirajo iz kliničnih preskušanj, študij varnosti po odobritvi dovoljenja za promet z zdravilom in izkušenj s posameznimi sestavinami v obdobju trženja.
English: Therapeutic experience in patients 65 years and older is limited, and very limited in patients 75 years and older.
Slovenian: Terapevtskih izkušenj pri bolnikih, starih 65 let ali več, je malo, pri bolnikih, starih 75 let ali več, pa zelo malo.
English: * LRM = Longitudinal repeated measures using values prior to rescue.
Slovenian: * LPM = longitudinalne ponovljene meritve z uporabo vrednosti pred reševalnim ukrepanjem.
English: Common A Uncommon B Rare Very rare Not known
Slovenian: Zelo redki Neznana pogostnost
English: Patients should be advised of the characteristic symptoms of heart failure, and to immediately report such symptoms.
Slovenian: Bolnike je treba seznaniti z značilnimi simptomi srčnega popuščanja in jim naročiti, da morajo o takšnih simptomih takoj poročati.
English: The safety and efficacy in patients with type 1 diabetes have not been established and Qtrilmet should not be used in patients with type 1 diabetes.
Slovenian: Varnost in učinkovitost pri bolnikih s sladkorno boleznijo tipa 1 nista ugotovljeni in zdravila Qtrilmet se ne sme uporabljati za zdravljenje takšnih bolnikov.
English: This may occur regardless of blood glucose level.
Slovenian: To se lahko pojavi ne glede na koncentracijo glukoze v krvi.
English: These may be symptoms of another rare, but very serious, sometimes life-threatening condition called diabetic ketoacidosis.
Slovenian: To so lahko simptomi druge redke, toda zelo resne in včasih smrtno nevarne motnje, imenovane diabetična ketoacidoza.
English: It is important to check your feet regularly - and follow the advice on foot care from your health care professional.
Slovenian: Pomembno je redno pregledovanje stopal in upoštevanje vseh nasvetov za oskrbo stopal, ki ste jih dobili od zdravstvenega delavca.
English: This decrease in mean absolute lymphocyte count was not associated with clinically relevant adverse reactions.
Slovenian: To zmanjšanje povprečnega absolutnega števila limfocitov ni bilo povezano s klinično pomembnimi neželenimi učinki.
English: Due to its mechanism of action, patients taking dapagliflozin will test positive for glucose in their urine.
Slovenian: Zaradi mehanizma delovanja zdravila imajo bolniki, ki jemljejo dapagliflozin, pozitiven izvid testa za glukozo v urinu.
English: Qtrilmet must be discontinued at the time of surgery with general, spinal or epidural anaesthesia.
Slovenian: Uporabo zdravila Qtrilmet je treba prekiniti v času kirurškega posega v splošni, spinalni ali epiduralni anesteziji.
English: In particular, talk to your doctor before taking Qtrilmet if you are taking any of the following medicines:
Slovenian: Še zlasti se pred uporabo zdravila Qtrilmet posvetujte z zdravnikom, če jemljete katero od naslednjih zdravil:
English: If you have type 2 diabetes, your pancreas does not make enough insulin or your body is not able to use the insulin it produces properly.
Slovenian: Če imate sladkorno bolezen tipa 2, v trebušni slinavki ali ne nastaja dovolj insulina ali pa telo ne zmore uporabiti insulina, ki ustrezno nastaja v trebušni slinavki.
English: Avoid excessive alcohol intake while taking Qtrilmet since this may increase the risk of lactic acidosis (see “Warnings and precautions” and “Do not take Qtrilmet if you”).
Slovenian: Med jemanjem zdravila Qtrilmet se izogibajte prekomernemu uživanju alkohola, kajti to lahko poveča tveganje za laktacidozo (glejte “Opozorila in previdnostni ukrepi” in “Ne jemljite zdravila Qtrilmet”).
English: Metformin: Plasma protein binding is negligible.
Slovenian: Metformin: Vezava na beljakovine v plazmi je zanemarljiva.
English: It is taken on its own, or it can be combined with a different type of diabetes medicine called a sulphonylurea.
Slovenian: Uporablja se samo, mogoče pa ga je uporabljati tudi v kombinaciji z drugačno vrsto zdravil za sladkorno bolezen, imenovano sulfonilsečnine.
English: There was no effect of food on Cmax and Tmax of metformin.
Slovenian: Hrana ni vplivala na Cmax in tmax metformina.
English: Your doctor may ask you to stop taking Qtrilmet.
Slovenian: Zdravnik vam lahko naroči, da nehate jemati zdravilo Qtrilmet.
English: Therefore, dapagliflozin is not expected to alter the metabolic clearance of co-administered medicinal products that are metabolised by these enzymes.
Slovenian: Zato ni pričakovati, da bi dapagliflozin spremenil presnovni očistek sočasno uporabljenih zdravil, ki jih presnavljajo ti encimi.
English: Qtrilmet is only given to adults aged 18 years and older.
Slovenian: Zdravilo Qtrilmet se uporablja le pri odraslih, starih 18 let ali več.
English: The absolute oral bioavailability of dapagliflozin following the administration of a 10 mg dose is 78%.
Slovenian: Absolutna peroralna biološka uporabnost dapagliflozina po uporabi 10-mg odmerka je 78 %.
English: The clinical relevance of the skin lesions is not known, and skin lesions have not been observed in humans.
Slovenian: Klinični pomen kožnih sprememb ni znan in pri človeku kožnih sprememb niso opazili.
English: Before initiating Qtrilmet, factors in the patient history that may predispose to ketoacidosis should be considered.
Slovenian: Pred uvedbo zdravila Qtrilmet je treba v bolnikovi anamnezi oceniti dejavnike, ki bi lahko povečali nagnjenost h ketoacidozi.
English: Dapagliflozin: Dapagliflozin is approximately 91% protein bound.
Slovenian: Dapagliflozin: Dapagliflozin je približno 91-odstotno vezan na beljakovine.
English: Metformin No clinically relevant interaction has been identified.
Slovenian: Metformin Klinično pomembnega medsebojnega delovanja niso ugotovili.
English: If this happens you must stop taking Qtrilmet and contact a doctor or the nearest hospital immediately, as lactic acidosis may lead to coma.
Slovenian: Če se to zgodi, morate prenehati jemati zdravilo Qtrilmet in se nemudoma posvetovati z zdravnikom ali iti v najbližjo bolnišnico, kajti laktacidoza lahko vodi v komo.
English: The patient should be informed and more frequent blood glucose monitoring performed, especially at the beginning of treatment with such medicinal products, and observed for loss of blood glucose control or hypoglycaemia.
Slovenian: Bolnika je treba s tem seznaniti in potrebno je pogosto spremljanje glukoze v krvi, zlasti na začetku zdravljenja s takšnimi zdravili; bolnika je treba spremljati glede izgube nadzora nad glukozo v krvi ali hipoglikemije.
English: Each tablet is to be swallowed whole.
Slovenian: Bolnik mora vsako tableto pogoltniti celo.
English: The treatment groups were proportionally well balanced with regard to demographics, subject characteristics, disease characteristics, and medical history.
Slovenian: Terapevtske skupine so bile v razmerjih dobro uravnotežene, kar zadeva demografske značilnosti, značilnosti preiskovancev, značilnosti bolezni in zdravstveno anamnezo.
English: Thereafter, glimepiride/placebo dose were kept constant, except for down-titration to prevent hypoglycaemia.
Slovenian: Potem je ostal odmerek glimepirida/placeba stalen, razen v primeru zmanjšanja za preprečitev hipoglikemij.
English: What you need to know before you take Qtrilmet
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Qtrilmet
English: Do not take Qtrilmet if any of the above apply to you.
Slovenian: Ne vzemite zdravila Qtrilmet, če kaj od naštetega velja za vas.
English: The corresponding plasma Cmax values were 24 ng/mL and 47 ng/mL, respectively.
Slovenian: Ustrezni vrednosti Cmax v plazmi sta bili 24 ng/ml in 47 ng/ml.
English: When starting or using such products in combination with metformin, close monitoring of renal function is necessary.
Slovenian: Na začetku uporabe in med uporabo takšnih zdravil v kombinaciji z metforminom je treba skrbno spremljati delovanje ledvic.
English: The effect in HbA1c observed at week 24 was sustained at week 52.
Slovenian: Učinek na HbA1c, opažen 24. teden, se je ohranil do 52. tedna.
English: Each tablet contains 48 mg of lactose (as anhydrous).
Slovenian: Ena tableta vsebuje 48 mg laktoze (v obliki brezvodne laktoze).
English: The same recommendations for monitoring of renal function apply to elderly patients as to all patients (see sections 4.2, 4.4, 4.8 and 5.1).
Slovenian: Glede spremljanja delovanja ledvic veljajo za starejše bolnike enaka priporočila kot za vse bolnike (glejte poglavja 4.2, 4.4, 4.8 in 5.1).
English: Saxagliptin: Across clinical studies in the saxagliptin programme a small decrease in absolute lymphocyte count was observed, approximately 100 cells/microL relative to placebo.
Slovenian: Saksagliptin: V programu kliničnih študij saksagliptina so opažali majhno zmanjšanje absolutnega števila limfocitov, približno 100 celic/mikroliter v primerjavi s placebom.
English: Diabetic skin and foot problems
Slovenian: Diabetične kožne spremembe in težave s stopali
English: Diagnostic laboratory findings are decreased blood pH (< 7.35), increased plasma lactate levels above 5 mmol/L, and an increased anion gap and lactate/pyruvate ratio.
Slovenian: Diagnostični laboratorijski izvidi so zmanjšan pH krvi (< 7,35), zvišane ravni laktata v plazmi nad 5 mmol/l ter povečana anionska vrzel in razmerje laktat/piruvat.
English: Considering the short latency between first drug exposure and tumour diagnosis, a causal relationship to any specific tumour type is considered unlikely.
Slovenian: Glede na kratko latenco med prvo izpostavljenostjo zdravilu in diagnozo tumorja vzročna povezava z nobeno od specifičnih vrst tumorjev ni verjetna.
English: No dose adjustment is recommended.
Slovenian: Ni priporočil za prilagoditev odmerka.
English: Monitoring glycaemic control with 1,5-AG assay is not recommended as measurements of 1,5-AG are unreliable in assessing glycaemic control in patients taking SGLT2 inhibitors.
Slovenian: Spremljanje urejenosti glikemije s testom z 1,5-AG ni priporočljivo, ker so meritve 1,5-AG nezanesljive za ocenjevanje urejenosti glikemije pri bolnikih, ki prejemajo zaviralce SGLT2.
English: In case of dehydration (severe diarrhoea or vomiting, fever or reduced fluid intake), Qtrilmet should be temporarily discontinued and contact with a health care professional is recommended.
Slovenian: V primeru dehidracije (huda driska ali bruhanje, zvišana telesna temperatura ali zmanjšan vnos tekočine) je treba uporabo zdravila Qtrilmet začasno prekiniti in priporočljivo je, da se bolnik posvetuje z zdravstvenim delavcem.
English: Metformin: Renal clearance of metformin is > 400 mL/min, indicating that metformin is eliminated by glomerular filtration and tubular secretion.
Slovenian: Metformin: Ledvični očistek metformina je > 400 ml/min, kar kaže, da se zdravilo izloča z glomerularno filtracijo in tubularno sekrecijo.