FrancophonIA/ELRC3.0 huggingface dataset:
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Danish: De kan finde yderligere oplysninger om Mimpara på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu
English: • medicines used to treat bacterial infections (telithromycin, rifampicin and ciprofloxacin);
Danish: • medicin, som anvendes til behandling af bakterieinfektioner (telithromycin, rifampicin og ciprofloxacin),
English: Soon after dosing, PTH begins to decrease until a nadir at approximately 2 to 6 hours post-dose, corresponding with cinacalcet Cmax.
Danish: PTH begynder at falde kort tid efter dosering indtil nadir ca. 2-6 timer efter dosering, som stemmer overens med cinacalcet-Cmax.
English: Paediatric Population: The pharmacokinetics of cinacalcet was studied in paediatric patients with ESRD receiving dialysis aged 3 to 17 years of age.
Danish: Pædiatrisk population: De farmakokinetiske egenskaber for cinacalcet blev undersøgt hos pædiatriske patienter med ESRD i dialysebehandling i alderen 3 til 17 år.
English: Dosing recommendations
Danish: Anbefalinger til dosering
English: What Mimpara contains - The active substance is cinacalcet.
Danish: Mimpara indeholder - Aktivt stof: cinacalcet.
English: • medicines used to treat depression (amitriptyline, desipramine, nortriptyline and clomipramine);
Danish: • medicin, som anvendes til behandling af depression (amitriptylin, desipramin, nortriptylin og clomipramin),
English: Since cinacalcet lowers serum calcium, patients should be monitored carefully for the occurrence of hypocalcaemia (see section 4.2).
Danish: Da cinacalcet sænker serumcalciumniveauet, skal patienterne omhyggeligt overvåges for forekomst af hypokalcæmi (se pkt.
English: A small bowl, cup or spoon with soft food (such as apple sauce or yogurt) or liquid (such as apple juice or renal infant formula).
Danish: En lille skål, kop eller ske med søbemad (for eksempel æblegrød eller youghurt) eller væske (for eksempel æblejuice eller modermælkserstatning til nyrebørn).
English: Worsening heart failure† QT prolongation and ventricular arrhythmia secondary to hypocalcaemia†
Danish: Forværring af hjerteinsufficiens† QT-forlængelse og ventrikulær arytmi sekundært til hypokalcæmi†
English: Corrected serum calcium should be measured and monitored and should be at or above the lower limit of the normal range prior to administration of first dose of Mimpara (see section 4.4).
Danish: Korrigeret serumcalcium bør måles og monitoreres og bør være ved eller over den nedre grænse for normalområdet inden administration af den første dosis Mimpara (se pkt.
English: Serum calcium
Danish: Serumcalcium
English: For patients who cannot swallow, you can administer the granules through a tube into the stomach (“nasogastric” or “gastrostomy” tubes, made of polyvinylchloride) in a small amount of water (at least 5 mL).
Danish: Hvis patienten ikke kan synke, kan granulatet tages gennem en sonde i maven (en “nasogastrisk sonde” eller “gastrostomisonde”, der er fremstillet af polyvinylklorid) i en lille smule vand (mindst 5 ml).
English: After steady state is reached, serum calcium concentrations remain constant over the dosing interval.
Danish: Når steady state er nået, forbliver serumcalciumkoncentrationen konstant i doseringsintervallet.
English: Before you start taking Mimpara, tell your doctor if you have or have ever had:
Danish: Tal med Deres læge, før De begynder at tage Mimpara, hvis De lider eller nogen sinde har lidt af:
English: Granules mixed with soft food or liquid should be administered immediately.
Danish: Granulat blandet med søbemad eller væske skal indgives med det samme.
English: Cinacalcet decreased iPTH and Ca x P, calcium and phosphorus levels regardless of baseline iPTH or Ca x P level, dialysis modality (PD versus HD), duration of dialysis, and whether or not vitamin D sterols were administered.
Danish: Cinacalcet sænkede niveauet af iPTH og Ca x P, calcium og fosfor uanset baseline-iPTH eller Ca x P-niveau, dialysemodalitet (PD i forhold til HD), dialysens varighed, og hvorvidt der blev administreret D-vitamin-steroler eller ej.
English: The threshold for seizures is lowered by significant reductions in serum calcium levels.
Danish: Tærsklen for krampeanfald sænkes ved betydelig reduktion i serumcalciumniveauet.
English: The safety and efficacy of Mimpara in children aged less than 3 years for the treatment of secondary hyperparathyroidism have not been established.
Danish: Mimparas sikkerhed og virkning hos børn under 3 år til behandling af sekundær hyperparatyroidisme er ikke klarlagt.
English: Upper respiratory infection Dyspnoea
Danish: Infektion i øvre luftveje Dyspnø
English: White to off-white granules in capsules for opening.
Danish: Hvidt til offwhite granulat i kapsler til åbning
English: Administer Mimpara with caution in patients receiving any other medicinal products known to lower serum calcium.
Danish: Mimpara skal anvendes med forsigtighed til patienter, der får andre lægemidler, som vides at sænke serumcalcium.
English: “Primary” means that the hyperparathyroidism is not caused by any other condition and “secondary” means that the hyperparathyroidism is caused by another condition, e.g. kidney disease.
Danish: Ved primær og sekundær hyperparatyroidisme afgiver biskjoldbruskkirtlerne for meget PTH. “Primær” betyder, at hyperparatyroidismen ikke skyldes nogen anden tilstand, og “sekundær” betyder, at hyperparatyroidismen skyldes en anden tilstand, for eksempel nyresygdom.
English: QT prolongation and ventricular arrhythmia secondary to hypocalcaemia QT prolongation and ventricular arrhythmia secondary to hypocalcaemia have been identified during post-marketing use of Mimpara, the frequencies of which cannot be estimated from available data (see section 4.4).
Danish: QT-forlængelse og ventrikulær arytmi sekundært til hypokalcæmi I forbindelse med anvendelse af Mimpara efter markedsføring er der påvist QT-forlængelse og ventrikulær arytmi sekundært til hypokalcæmi, men hyppigheden kan ikke estimeres ud fra de forhåndenværende data (se pkt.
English: Investigational studies in patients with CKD and secondary HPT not undergoing dialysis indicated that cinacalcet reduced PTH levels to a similar extent as in patients with ESRD and secondary HPT receiving dialysis.
Danish: Studier af patienter med CKD og sekundær HPT, der ikke var i dialysebehandling, indikerede, at cinacalcet reducerede PTH-niveauet i et lignende omfang som hos patienter med ESRD og sekundær HPT, der var i dialyse.
English: • If iPTH < 100 pg/mL (10.6 pmol/L), stop Mimpara treatment, restart Mimpara at the next lower dose once the iPTH is > 150 pg/mL (15.9 pmol/L).
Danish: • Hvis iPTH < 100 pg/ml (10,6 pmol/l), skal Mimpara seponeres og reinitieres ved den næste lavere dosis, når iPTH er > 150 pg/ml (15,9 pmol/l).
English: Both primary and secondary hyperparathyroidism can cause the loss of calcium in the bones, which can lead to bone pain and fractures, problems with blood and heart vessels, kidney stones, mental illness and coma.
Danish: Både primær og sekundær hyperparatyroidisme kan medføre et for lavt calciumniveau i knoglerne, som kan give smerter i knoglerne, knoglebrud, hjerte-kar-sygdom, nyresten, psykiske lidelser og koma.
English: • to treat secondary hyperparathyroidism in patients with serious kidney disease who need dialysis to clear their blood of waste products, whose condition is not controlled with other treatments.
Danish: • at behandle sekundær hyperparatyroidisme hos patienter med alvorlig nyresygdom, som har behov for dialyse for at fjerne affaldsprodukter fra blodet, og hvis sygdom ikke kan kontrolleres med andre behandlinger.
English: Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.
Danish: Brug ikke dette lægemiddel efter den udløbsdato, der står på pakningen og blisterkortet efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: In the event that corrected serum calcium levels fall below 8.4 mg/dL (2.1 mmol/L) and/or symptoms of hypocalcaemia occur the following management is recommended:
Danish: Hvis de korrigerede serumcalciumniveauer falder til under 8,4 mg/dl (2,1 mmol/l), og/eller der opstår symptomer på hypocalcæmi, anbefales følgende behandling:
English: • Microcrystalline cellulose
Danish: • Mikrokrystallinsk cellulose,
English: Significant reductions in iPTH, serum calcium-phosphorus product (Ca x P), calcium, and phosphorus were observed in the cinacalcet-treated patients compared with placebo-treated patients receiving standard of care, and the results were consistent across the 3 studies.
Danish: Der blev observeret signifikante reduktioner i iPTH, serumcalcium-fosforprodukt (Ca x P), serumcalcium og fosfor hos de patienter, der blev behandlet med cinacalcet, sammenlignet med de patienter, der gennemgik standardplacebobehandling, og resultaterne var konsekvente i alle 3 studier.
English: Treatment of secondary hyperparathyroidism (HPT) in adult patients with end-stage renal disease (ESRD) on maintenance dialysis therapy.
Danish: Behandling af sekundær hyperparatyroidisme (HPT) hos voksne patienter med slutstadium af nyresygdom (ESRD) i vedligeholdelsesdialyseterapi.
English: Withhold administration of Mimpara until serum calcium levels reach 8.0 mg/dL (2.0 mmol/L) and/or symptoms of hypocalcaemia have resolved.
Danish: Seponer Mimpara, indtil serumcalciumniveauerne når 8,0 mg/dl (2,0 mmol/l), og/eller symptomer på hypocalcæmi er svundet.
English: Desipramine: Concurrent administration of 90 mg cinacalcet once daily with 50 mg desipramine, a tricyclic antidepressant metabolised primarily by CYP2D6, significantly increased desipramine exposure 3.6-fold (90% CI 3.0, 4.4) in CYP2D6 extensive metabolisers.
Danish: Desipramin: Samtidig administration af 90 mg cinacalcet én gang dagligt med 50 mg desipramin, som er et tricyklisk antidepressivum, der primært metaboliseres af CYP2D6, øgede desipramineksponeringen betydeligt med ca. 3,6 gange (90 % CI 3,0; 4,4) hos ekstensive CYP2D6-metabolisers.
English: • a medicine used to treat high blood pressure (metoprolol).
Danish: • medicin, som anvendes til behandling af forhøjet blodtryk (metoprolol).
English: After taking Mimpara a very small number of patients with heart failure had worsening of their condition and/or low blood pressure (hypotension).
Danish: I meget få tilfælde hos patienter med hjertesvigt blev dette forværret efter indtagelse af Mimpara, og/eller patienterne fik lavt blodtryk (hypotension).
English: Mimpara may be used as part of a therapeutic regimen including phosphate binders and/or Vitamin D sterols, as appropriate (see section 5.1).
Danish: Mimpara kan bruges som en del af en terapeutisk behandling, som omfatter fosfatbindere og/eller D-vitamin-steroler efter behov (se pkt.
English: This study was terminated early due to a fatality with severe hypocalcaemia in the cinacalcet group (see section 4.8).
Danish: Dette studie blev afbrudt før det planlagte tidspunkt på grund af et dødsfald som følge af svær hypocalcæmi i cinacalcet-gruppen (se pkt.
English: The entire granules should be sprinkled on to a small amount of soft food (e.g. apple sauce or yogurt) or liquid (e.g. apple juice or renal infant formula), and swallowed.
Danish: Hele granulatet skal drysses hen over en lille mængde søbemad (f.eks. æblegrød eller youghurt) eller væske (f.eks. æblejuice eller modermælkserstatning til nyrebørn) og synkes.
English: In patients with parathyroid carcinoma, mean serum calcium declined from 14.1 mg/dL to 12.4 mg/dL (3.5 mmol/L to 3.1 mmol/L), while in patients with primary HPT, serum calcium levels declined from 12.7 mg/dL to 10.4 mg/dL (3.2 mmol/L to 2.6 mmol/L).
Danish: Hos patienter med cancer i paratyroidea faldt det gennemsnitlige serumcalciumniveau fra 14,1 mg/dl til 12,4 mg/dl (3,5 mmol/l til 3,1 mmol/l) medens serumcalciumniveauet hos patienter med primær HPT faldt fra 12,7 mg/dl til 10,4 mg/dl (3,2 mmol/l til 2,6 mmol/l).
English: Mean baseline iPTH concentrations across the 3 studies were 733 and 683 pg/mL (77.8 and 72.4 pmol/L) for the cinacalcet and placebo groups, respectively.
Danish: De gennemsnitlige baseline-iPTH-koncentrationer i de 3 studier var henholdsvis 733 og 683 pg/ml (77,8 og 72,4 pmol/l) for grupperne med cinacalcet og placebo.
English: • medicines used to treat changes in heart rate (flecainide and propafenone);
Danish: • medicin, som anvendes til behandling af hjerterytmeforstyrrelser (flecainid og propafenon),
English: The capsules are provided in High Density Polyethylene (HDPE) bottle with a foil induction seal and a child-resistant polypropylene cap, packed into a carton.
Danish: Kapslerne leveres i en HDPE-flaske (polyetylen med høj densitet) med en folieinduktionsforsegling samt børnesikret polypropylenlåg, pakket i en æske.
English: Once the maintenance dose has been established, weekly measurement of serum calcium is recommended.
Danish: Når vedligeholdelsesdosen er fastlagt, anbefales ugentlige målinger af serumcalcium.
English: ≤ 7.5 mg/dL (1.9 mmol/L) or persistent symptoms of hypocalcaemia and Vitamin D cannot be increased
Danish: ≤ 7,5 mg/dl (1,9 mmol/l) eller vedvarende symptomer på hypocalcæmi, og vitamin D kan ikke forhøjes
English: A significantly higher percentage of cinacalcet-treated patients achieved mean corrected total serum calcium concentration ≤ 10.3 mg/dL (2.57 mmol/L) and ≥ 1 mg/dL (0.25 mmol/L) decrease from baseline in mean corrected total serum calcium concentration, when compared with the placebo-treated patients (75.8% versus 0% and 84.8% versus 5.9% respectively).
Danish: En betydeligt højere procentdel af patienter, der blev behandlet med cinacalcet, opnåede et gennemsnitligt korrigeret total serumcalcium på ≤ 10,3 mg/dl (2,57 mmol/l) og et fald på ≥ 1 mg/dl (0,25 mmol/l) i forhold til baseline i gennemsnitligt korrigeret total serumcalcium sammenlignet med placebobehandlede patienter (henholdsvis 75,8 % vs. 0 % og 84,8 % vs. 5,9 %).
English: • to treat secondary hyperparathyroidism in adults with serious kidney disease who need dialysis to clear their blood of waste products.
Danish: • at behandle sekundær hyperparatyroidisme hos voksne med alvorlig nyresygdom, som har behov for dialyse for at fjerne affaldsprodukter fra blodet.
English: Other medicines and Mimpara
Danish: Brug af anden medicin sammen med Mimpara
English: In a 28 week placebo-controlled study, 67 adult patients with primary HPT who met criteria for parathyroidectomy on the basis of corrected total serum calcium (> 11.3 mg/dL (2.82 mmol/L) but ≤ 12.5 mg/dL (3.12 mmol/L), but who were unable to undergo parathyroidectomy were included.
Danish: I et 28 ugers placebokontrolleret studie deltog 67 voksne patienter med primær HPT, der opfyldte kriterierne for paratyreoidektomi med hensyn til korrigeret total serumcalcium >11,3 mg/dl (2,82 mmol/l), men ≤ 12,5 mg/dl (3,12 mmol/l), men som ikke kunne gennemgå paratyreoidektomi.
English: PHARMACEUTICAL FORM AND CONTENTS 14 tablets
Danish: LÆGEMIDDELFORM OG INDHOLD (PAKNINGSSTØRRELSE) 14 tabletter
English: • to reduce high levels of calcium in the blood (hypercalcaemia) in adult patients with parathyroid cancer.
Danish: • at reducere forhøjede calciumniveauer i blodet (hyperkalcæmi) hos voksne patienter med biskjoldbruskkirtelkræft.
English: * Administer calcium supplements, calcium-containing phosphate binders and/or vitamin D sterols, as clinically indicated.
Danish: Administrer calciumtilskud, calciumholdige fosfatbindere og/eller D-vitamin-steroler som klinisk indiceret.
English: High Density Polyethylene (HDPE) bottle with a cotton coil, and a child-resistant polypropylene cap with an induction seal, packed into a carton.
Danish: HDPE-flaske (polyetylen med høj densitet) med en bomuldsring samt børnesikret polypropylenlåg med induktionsforsegling, pakket i en æske.
English: You should take the granules with food or liquid.
Danish: Granulatet skal tages sammen med mad eller væske.
English: • a medicine used to relieve cough (dextromethorphan);
Danish: • medicin, som anvendes til at lindre hoste (dextromethorphan),
English: • to reduce high levels of calcium in the blood (hypercalcaemia) in adult patients with primary hyperparathyroidism when removal of the gland is not possible.
Danish: • at reducere forhøjede calciumniveauer i blodet (hyperkalcæmi) hos voksne patienter med primær hyperparatyroidisme, hvor det ikke er muligt at fjerne biskjoldbruskkirtlen.
English: Eighteen (18) of 29 patients (62%) with parathyroid carcinoma and 15 of 17 subjects (88%) with primary HPT achieved a reduction in serum calcium of ≥ 1 mg/dL (≥ 0.25 mmol/L).
Danish: Atten (18) af 29 (62 %) patienter med cancer i paratyroidea samt 15 af 17 (88 %) patienter med primær HPT opnåede en reduktion i serumcalciumniveauet på ≥ 1 mg/dl (≥ 0,25 mmol/l).
English: PTH levels should be assessed at least 12 hours after dosing with Mimpara and iPTH should be measured 1 to 4 weeks after initiation or dose adjustment of Mimpara.
Danish: PTH-niveauerne skal måles mindst 12 timer efter dosering af Mimpara, og iPTH skal måles 1-4 uger efter initiering eller dosisjustering af Mimpara.
English: • Empty the entire contents of the bottom of the capsule onto the food or liquid.
Danish: • Tøm hele indholdet af den nederste del af kapslen ud over maden eller væsken.
English: Prior to initiating cinacalcet and during treatment, consider the risks and benefits of treatment and the ability of the patient to comply with the recommendations to monitor and manage the risk of hypocalcaemia.
Danish: Behandlingens risici og fordele og patientens evne til at følge anbefalingerne til monitorering og håndtering af risikoen for hypocalcæmi skal overvejes inden initiering af cinacalcet og under behandlingen.
English: Do not take a double dose to make up for a forgotten dose.
Danish: Hvis De har glemt at tage Mimpara De må ikke tage en dobbeltdosis som erstatning for den glemte tablet.
English: • breathing difficulties (dyspnoea)
Danish: • vejrtrækningsbesvær (dyspnø),
English: The safety and efficacy of Mimpara in children for the treatment of parathyroid carcinoma and primary hyperparathyroidism have not been established.
Danish: Mimparas sikkerhed og virkning hos børn til behandling af cancer i paratyroidea og primær hyperparatyroidisme er ikke klarlagt.
English: This analysis showed no significant impact of age, sex, race, body surface area, and body weight on cinacalcet pharmacokinetics.
Danish: Denne analyse viste ingen signifikant indvirkning på cinacalcets farmakokinetik som følge af alder, køn, race, legemsoverfladeareal og legemsvægt.
English: Do not store Mimpara mixed with food or liquid.
Danish: Mimpara må ikke opbevares sammen med mad eller væske.
English: Patients receiving Mimpara should not be given etelcalcetide.
Danish: Patienter, der får Mimpara, må ikke få etelcalcetid.
English: Life threatening events and fatal outcomes associated with low calcium levels (hypocalcaemia) have been reported in adults and children treated with Mimpara.
Danish: Der er indberettet livstruende hændelser og dødeligt udfald i forbindelse med lave calciumniveauer (hypokalcæmi) hos voksne og børn, der blev behandlet med Mimpara.
English: Granules are provided in capsules for opening.
Danish: Granulatet fås i kapsler til åbning.
English: • If you experience swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing (angioedema).
Danish: • hvis De får hævelse i ansigt, læber, mund, tunge eller hals, som kan give synke- eller åndedrætsbesvær (angioødem).
English: The recommended starting dose for adults is 30 mg once per day.
Danish: Den anbefalede startdosis er for voksne 30 mg én gang daglig.
English: The capsules should not be swallowed.
Danish: Kapslerne må ikke synkes.
English: • Titanium dioxide (E171) (1 mg, 2.5 mg and 5 mg capsules)
Danish: • Titandioxid (E171) (1 mg, 2,5 mg og 5 mg kapsler)
English: During treatment with Mimpara, tell your doctor:
Danish: Tal med deres læge undervejs i behandlingen med Mimpara:
English: Once maintenance dose levels have been established, serum calcium should be measured every 2 to 3 months.
Danish: Når niveauerne for vedligeholdelsesdosis er blevet fastslået, skal serumcalcium måles hver 2.-3. måned.
English: Very common: may affect more than 1 in 10 people • nausea and vomiting, these side effects are normally quite mild and do not last for long.
Danish: Meget almindelige: kan ramme mere end 1 ud af 10 personer • kvalme og opkastning.
English: Mimpara is available in bottles of 1 mg, 2.5 mg or 5 mg capsules, inside a carton.
Danish: Mimpara fås i flasker med 1 mg, 2,5 mg eller 5 mg kapsler i en æske.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Danish: Bør ikke anvendes til patienter med arvelig galactoseintolerans, en særlig form af arvelig lactasemangel (Lapp Lactase deficiency) eller glucose-/galactose-malabsorption.
English: • Amorphous silicon dioxide
Danish: • Amorf siliciumdioxid.
English: The efficacy and safety of cinacalcet for the treatment of secondary HPT in paediatric patients with ESRD receiving dialysis was evaluated in two randomised controlled studies and one single-arm study.
Danish: Cinacalcets virkning og sikkerhed i behandlingen af sekundær HPT hos pædiatriske patienter med ESRD, der er i dialysebehandling, blev undersøgt i to randomiserede, kontrollerede studier og et studie med en enkelt behandlingsarm.
English: Corrected serum calcium at or below age-specified lower limit of normal or if symptoms of hypocalcaemia occur, regardless of calcium level.
Danish: Korrigeret serumcalcium på eller under den aldersspecifikke nedre grænse af normalområdet eller i tilfælde af symptomer på hypocalcæmi, uanset calciumniveauet.
English: • numbness or tingling sensation (paraesthesia)
Danish: • følelsesløshed eller prikkende fornemmelse (paræstesi),
English: The majority of patients (75%) were using vitamin D sterols at baseline.
Danish: Størstedelen af patienterne (75 %) brugte vitamin D-steroler ved baseline.
English: 90 mg tablets are approximately 13.9 mm long and 8.7 mm wide.
Danish: 90 mg tabletter er cirka 13,9 mm lange og 8,7 mm brede.
English: The majority of patients (91%) were using vitamin D sterols at baseline.
Danish: Størstedelen af patienterne (91 %) brugte vitamin D-steroler ved baseline.
English: In one study, 46 adult patients (29 with parathyroid carcinoma and 17 with primary HPT and severe hypercalcaemia who had failed or had contraindications to parathyroidectomy) received cinacalcet for up to 3 years (mean of 328 days for patients with parathyroid carcinoma and mean of 347 days for patients with primary HPT).
Danish: I et studie fik 46 voksne patienter (29 med cancer i paratyroidea og 17 med primær HPT og svær hyperkalcæmi hvor paratyroidektomi var mislykket eller kontraindiceret) cinacalcet i op til 3 år (gennemsnitligt 328 dage for patienter med cancer i paratyroidea og gennemsnitligt 347 dage for patienter med primær HPT).
English: Abdominal pain Abdominal pain - upper Constipation
Danish: Abdominalsmerter Abdominalsmerter - øvre Obstipation
English: Mimpara should be used with caution in patients with moderate to severe hepatic impairment and treatment should be closely monitored during dose titration and continued treatment (see sections 4.4 and 5.2).
Danish: Mimpara skal anvendes med forsigtighed til patienter med moderat til svær leverinsufficiens, og behandlingen skal monitoreres nøje under dosistitrering og den videre behandling (se pkt.
English: Co-administration of 200 mg bid ketoconazole, a strong inhibitor of CYP3A4, caused an approximate 2-fold increase in cinacalcet levels.
Danish: Co-administration af ketoconazol (200 mg 2 gange daglig), en stærk hæmmer af CYP3A4, forårsagede en stigning i cinacalcet-niveauerne til ca. det dobbelte.
English: Either the intact PTH (iPTH) or bio-intact PTH (biPTH) may be used to measure PTH levels; treatment with Mimpara does not alter the relationship between iPTH and biPTH.
Danish: Enten det intakte PTH (iPTH) eller biointakte PTH (biPTH) kan bruges til at måle PTH-niveauet.
English: Capsule Printing ink: iron oxide black, shellac, propylene glycol
Danish: Kapsel Trykfarve: sort jernoxid, shellak, propylenglycol