FrancophonIA/ELRC3.0 huggingface dataset:
English: • increased blood levels of the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) or alkaline phosphatase (ALP).
Danish: • forhøjet mængde af leverenzymerne alanin-aminotransferase (ALAT) og aspartat aminotransferase (ASAT) eller basisk fosfatase i blodet (ALP)
English: When panobinostat is administered together with dexamethasone, which is known to be a weak to moderate inducer of CYP3A4 as well as other enzymes and transporters, the risk for reduced efficacy of hormonal contraceptives needs to be considered.
Danish: Når panobinostat administreres sammen med dexamethason, som vides at være en svag til moderat inducer af CYP3A4 samt andre enzymer og transportere, skal risikoen for nedsættelse af hormaonale kontraceptivas virkning tages i betragtning.
English: Elderly population
Danish: Ældre mennesker
English: • reduced blood level of magnesium
Danish: • nedsat mængde magnesium i blodet
English: Dizziness may occur following administration of Farydak (see section 4.8).
Danish: Svimmelhed kan opstå efter administration af Farydak (se pkt.
English: Inhibition of HDAC activity results in increased acetylation of histone proteins, an epigenetic alteration that results in a relaxing of chromatin, leading to transcriptional activation.
Danish: Hæmning af HDAC-aktivitet resulterer i øget acetylering af histonproteiner, en epigenetisk modifikation, der resulterer i løsere kromatin førende til transkriptionel aktivering.
English: The most frequently reported infections include upper respiratory tract infection, pneumonia and nasopharyngitis.
Danish: De hyppigst indberettede infektioner omfattede infektion i de øvre luftveje, pneumoni og nasopharyngitis.
English: Complete blood counts should be frequently monitored during treatment (in particular before each injection of bortezomib, i.e. on days 1, 4, 8 and 11 of cycles 1 to 8 and on days 1 and 8 of cycles 9 to 16), especially for thrombocytopenia (see section 4.4).
Danish: De komplette blodtællinger bør monitoreres hyppigt under behandlingen (særligt før hver injektion med bortezomib, fx på dag 1, 4, 8 og 11 i cyklus 1 til 8 og på dag 1 og 8 i cyklus 9 til 16), især for trombocytopeni (se pkt.
English: Farydak is always used together with two other medicines: bortezomib and dexamethasone.
Danish: Farydak bruges altid sammen med to andre typer medicin: bortezomib og dexamethason.
English: Concomitant use of anti-arrhythmic medicinal products (including, but not limited to, amiodarone, disopyramide, procainamide, quinidine and sotalol) and other substances that are known to prolong the QT interval (including, but not limited to, chloroquine, halofantrine, clarithromycin, methadone, moxifloxacin, bepridil and pimozide) is not recommended.
Danish: Samtidig brug af antiarytmisk medicin (herunder, men ikke begrænset til amiodaron, disopyramid, procainamid, quinidin og sotalol) og andre stoffer, der vides at forlænge QT-intervallet (herunder, men ikke begrænset til chloroquin, halofantrin, clarithromycin, methadon, moxifloxacin, bepridil og pimozid) frarådes.
English: • clicking, rattling or crackling noise made by the lungs when breathing
Danish: • klikkende, raslende eller knitrende lyd fra lungerne, når du trækker vejret
English: Haematological adverse drug reactions, including severe thrombocytopenia, neutropenia and anaemia (CTC grade 3 to 4) were reported in patients treated with panobinostat.
Danish: Hæmatologiske bivirkninger, herunder svær trombocytopeni, neutropeni og anæmi (CTC-grad 3 til 4) er blevet indberettet hos patienter, der blev behandlet med panobinostat.
English: Embryo foetal lethality and increases in skeletal anomalies (extra sternabrae, extra ribs, increases in minor skeletal variations, delayed ossification and variations of the sternabrae) were seen above exposures corresponding to 0.25 of the human clinical AUC.
Danish: Der sås embryo-føtal letalitet og stigning i skeletalanomalier (ekstra sternumled, ekstra ribben, stigning i mindre skeletvariationer, forsinket ossifikation og variationer af sternumled) ved højere eksponering svarende til 0,25 af det humane kliniske AUC.
English: 20.7% of patients experienced haemorrhage, most frequently epistaxis (4.7%), haematoma (2.6%), and conjunctival haemorrhage (2.1%).
Danish: 20,7 % af patienterne oplevede hæmoragi, som oftest epistaxis (4,7 %), hæmatom (2,6 %) og konjunktival hæmoragi (2,1 %).
English: - Store in the original package in order to protect from moisture.
Danish: • Opbevares i den originale yderpakning for at beskytte mod fugt.
English: Panobinostat is used in combination treatment, therefore the prescribing information of bortezomib and dexamethasone should be consulted prior to initiation of treatment with panobinostat.
Danish: Panobinostat anvendes som kombinationsbehandling, og derfor skal produktresuméerne for bortezomib og dexamethason gennemses, før der initieres behandling med panobinostat.
English: 10 mg, to be taken once a day on days 1, 3, 5, 8, 10 and 12 of the 21-day cycle.
Danish: 10 mg, som skal tages en gang daglig på dag 1, 3, 5, 8, 10 og 12 i den 21 dage lange behandlingscyklus.
English: Clinical efficacy in patients with bortezomib-refractory multiple myeloma (Study DUS71Panorama 2)
Danish: Klinisk effekt hos patienter med bortezomib-refraktær myelomatose (Forsøg DUS71 - Panorama 2)
English: Based on findings in animals, the likelihood of panobinostat increasing the risk of both foetal death and developmental skeletal abnormalities when administered to pregnant women is predicted to be high.
Danish: Baseret på resultater fra dyr forventes det, at der er stor sandsynlighed for, at panobinostat øger risikoen for både fosterdød og unormal skeletudvikling, når det administreres til gravide kvinder.
English: Co-administration of a single 20 mg panobinostat dose with ketoconazole, a strong CYP3A inhibitor, increased the Cmax and AUC of panobinostat by 1.6- and 1.8-fold, respectively, compared to when panobinostat was given alone.
Danish: Samtidig administration af en enkelt dosis på 20 mg panobinostat med ketoconazol, en stærk CYP3Ahæmmer, øgede panobinostats Cmax og AUC henholdsvis 1,6 og 1,8 gange sammenlignet med administration af panobinostat alene.
English: The efficacy and safety of panobinostat in combination with bortezomib and dexamethasone were evaluated in a randomised, double-blind, placebo-controlled, multicentre phase III study in patients with relapsed or relapsed and refractory multiple myeloma who had received 1-3 prior lines of therapies.
Danish: Panobinostats virkning og sikkerhed i kombination med bortezomib og dexamethason blev evalueret i et randomiseret, dobbeltblindet, placebokontrolleret, fase III-multicenterforsøg hos patienter med recidiverende eller recidiverende og behandlingsrefraktær myelomatose, som havde fået 1-3 tidligere behandlingslinjer.
English: Mild and moderate hepatic impairment as per NCI-CTEP classification increased panobinostat plasma exposure by 43% and 105%, respectively.
Danish: Mild og moderat leverinsufficiens ifølge NCI-CTEP-klassificeringen øgede plasmaeksponeringen for panobinostat med henholdsvis 43 % og 105 %.
English: At the first sign of abdominal cramping, loose stools or onset of diarrhoea, it is recommended that the patient be treated with anti-diarrhoeal medicinal product (e.g. loperamide) or any additional treatment in accordance with local treatment guidelines.
Danish: Ved første tegn på mavekramper, løs afføring eller begyndende diarré anbefales det, at patienten behandles med et lægemiddel mod diarré (f.eks. loperamid) eller en anden behandling i overensstemmelse med lokale behandlingsguidelines.
English: Clinical efficacy in patients with relapsed and relapsed and refractory multiple myeloma (Study D2308 - Panorama 1)
Danish: Klinisk virkning hos patienter med recidiverende og recidiverende og behandlingsrefraktær myelomatose (Forsøg D2308 - Panorama 1)
English: Tell your doctor or pharmacist straight away during treatment with Farydak: - if you notice any signs of a gastrointestinal problem.
Danish: Fortæl det straks til lægen eller apotekspersonalet under behandlingen med Farydak: - hvis du bemærker et eller flere tegn på et mave-tarmproblem.
English: How to use the Farydak blister
Danish: Sådan skal du bruge Farydak blisterpakning
English: In patients with CTC grade 3 thrombocytopenia (platelet count <50 x 109/l with bleeding) panobinostat may need to be temporarily withheld and/or the subsequent dose may need to be reduced.
Danish: Hos patienter med trombocytopeni CTC-grad 3 (trombocyttal <50 x 109/l med blødning) skal panobinostat eventuelt stoppes midlertidigt, og/eller den efterfølgende dosis skal eventuelt nedsættes.
English: Platelets <50 x 109/l with bleeding
Danish: Trombocytter <50 x 109/l med blødning
English: Platelet counts should be monitored prior to each dose of bortezomib (i.e. on days 1, 4, 8 and 11 of cycles 1-8, see Table 1, and on days 1 and 8 of cycles 9-16, see Table 2).
Danish: Trombocyttallet bør monitoreres før hver dosis bortezomib (fx på dag 1, 4, 8 og 11 i cyklus 1-8, se tabel 1, og på dag 1 og 8 i cyklus 9-16, se tabel 2).
English: Prior to initiating any cycle of therapy with panobinostat in combination with bortezomib and dexamethasone, platelet count should be at least ≥100 x 109/l (see section 4.4).
Danish: Før enhver behandlingscyklus med panobinostat i kombination med bortezomib og dexamethason påbegyndes, bør trombocyttallet være mindst ≥100 x 109/l (se pkt.
English: - If it is less than 12 hours since you should have taken the medicine, take the missed dose as soon as you remember.
Danish: - Hvis det er mindre end 12 timer siden, du skulle have taget medicinen, skal du tage den glemte dosis, så snart du kommer i tanke om det. Fortsæt derefter med at tage medicinen, som du plejer.
English: If a diagnosis of invasive systemic fungal infection is made, panobinostat should be discontinued and appropriate anti-fungal therapy instituted.
Danish: Hvis diagnosen invasiv systemisk svampeinfektion stilles, skal panobinostat omgående seponeres, og der skal iværksættes relevant antimykotisk behandling.
English: • fast weight gain, swelling of hands, ankles, feet or face (signs of water retention)
Danish: • hurtig vægtstigning, hævelse af hænder, ankler, fødder eller ansigt (tegn på vand i kroppen)
English: Omit dose Resume at reduced dose or with the same dose but with a once-weekly schedule
Danish: Udelad dosis Genoptag med nedsat dosis eller med samme dosis, men med en behandling én gang ugentligt
English: • inflamed ear, nose bleed or bleeding in the white of the eye, bruising, inflamed skin caused by infection (rash, red skin, which is also known as erythema)
Danish: • betændelse i øret, næseblod eller blødning i det hvide i øjnene, blodudtrædning, betændt hud forårsaget af infektion (udslæt, rød hud, hvilket også kaldes erytem)
English: For adverse drug reactions that are related to bortezomib or dexamethasone treatment, please refer to the relevant SmPC.
Danish: For bivirkninger, som er relateret til bortezomib eller dexamethason, se venligst det relevante produktresumé.
English: There is no relevant use of panobinostat in paediatric patients below the age of 18 years in the indication multiple myeloma (see section 5.2).
Danish: Det er ikke relevant at anvende panobinostat i den pædiatriske population under 18 år for indikationen myelomatose (se pkt.
English: The list of associated symptoms is provided in section 4, Possible side effects.
Danish: Listen over de tilknyttede symptomer findes i punkt.
English: Liver function should be monitored prior to treatment and regularly during treatment as clinically indicated, especially in patients with hepatic impairment (see section 4.4).
Danish: Leverfunktionen bør monitoreres før behandlingen og regelmæssigt under behandlingen som klinisk indiceret, især hos patienter med nedsat leverfunktion (se pkt.
English: Table 7 Panobinostat adverse drug reactions observed in multiple myeloma patients in the phase III study
Danish: Tabel 7 Panobinostat bivirkninger observeret hos patienter med myelomatose i fase IIIforsøget
English: QT prolongation and ECG abnormalities
Danish: QT-forlængelse og EKG-abnormiteter
English: Package leaflet: Information for the patient Farydak 10 mg hard capsules
Danish: Indlægsseddel: Information til patienten Farydak 10 mg hårde kapsler
English: Pre-existing infections should be treated prior to initiation of the therapy.
Danish: Før behandlingen påbegyndes skal eksisterende infektioner behandles.
English: If you are a sexually active woman, you should have a pregnancy test before starting Farydak treatment and you must use a highly effective method of contraception during treatment with Farydak.
Danish: Hvis du er en seksuelt aktiv kvinde, skal du have taget en graviditetstest, før du starter behandlingen med Farydak, og du skal bruge en yderst effektiv præventionsmetode under behandlingen med Farydak.
English: Blood electrolytes, especially potassium, magnesium and phosphorus, should be measured at baseline and monitored periodically as clinically indicated, especially in patients with diarrhoea.
Danish: Blodelektrolytter, især kalium, magnesium og fosfor, bør måles ved baseline og monitoreres periodisk ifølge klinisk indikation, særlig hos patienter med diarré.
English: The most common non-haematological adverse reactions were diarrhoea, fatigue, nausea and vomiting.
Danish: De mest almindelige ikke-hæmatologiske bivirkninger var diarré, træthed, kvalme og opkastning.
English: Progression-free survival Probability
Danish: Sandsynlighed for proressionsfri overlevelse (%)
English: Table 3 Recommended dose modifications for thrombocytopenia Thrombocytopenia grade on day of treatment
Danish: Tabel 3 Anbefalede dosismodifikationer ved thrombocytopeni Thrombocytopenigrad på behandlingsdagen
English: • new or worsening symptoms such as cough with or without mucus, fever, difficult or painful breathing, wheezing, pain in chest when breathing, shortness of breath or, difficulty breathing,
Danish: • nye eller forværrede symptomer, som fx hoste med eller uden slim, feber, besværet eller smertefuld vejrtrækning, hvæsende vejrtrækning, smerter i brystet, når du trækker vejret,
English: ≤1.0 x ULN >ULN Reduce panobinostat dose to 15 mg in the first treatment cycle.
Danish: ≤1,0 x ULN >ULN Nedsæt panobinostatdosis til 15 mg i den første behandlingscyklus.
English: • oral thrush (yeast infection of the mouth)
Danish: • trøske (gærinfektion i munden)
English: Prolongation of QT interval
Danish: Forlængelse af QT-interval
English: It is not known whether panobinostat is dialysable.
Danish: Det vides ikke, om panobinostat kan fjernes ved dialyse.
English: Panobinostat may prolong cardiac ventricular repolarisation (QT interval).
Danish: Panobinostat kan forlænge hjertets ventrikulære repolarisering (QT-interval).
English: CTC grade 3 or 4 haemorrhage was reported in 4.2% of patients, including cases of gastrointestinal and pulmonary haemorrhage with fatal outcomes.
Danish: Blødning i CTCgrad 3 eller 4 blev indberettet hos 4,2 % af patienterne, herunder tilfælde af gastrointestinal og pulmonal blødning med fatal udgang.
English: In patients with platelet count <50 x 109/l (complicated by bleeding) or <25 x 109/l, Farydak therapy should be withheld and resumed at a reduced dose upon recovery to platelet count ≥50 x 109/l.
Danish: Hos patienter med trombocyttal<50 x 109/l, kompliceret af blødning) eller <25 x 109/l), bør behandlingen med Farydak seponeres og genoptages med nedsat dosis efter bedring til trombocyttal ≥50 x 109/l).
English: Very common Decreased appetite, hypophosphataemia a, hyponatraemia a, hypokalaemia a
Danish: Metabolisme og ernæring Meget almindelig Nedsat appetit, hypofosfatæmi a, hyponatriæmi a, hypokaliæmi a
English: Progression-free survival Median, months [95% CI] Hazard ratio [95% CI]1
Danish: Progressionsfri overlevelse Median, måneder [95 %
English: • difficulty in breathing with blueness around the mouth, which could lead to loss of consciousness (sign of serious lung problems)
Danish: • vejrtrækningsbesvær med blåfarvning omkring munden, som kan medføre besvimelse (tegn på alvorlige lungeproblemer)
English: • The dose should be omitted, if QTcF is ≥480 msec or above 60 msec from baseline.
Danish: • Dosis skal udelades, hvis QTcF er ≥480 msek.
English: - medicines used to stop seizures or fits (anti-epileptics such as carbamazepine, pherphenazine,
Danish: - medicin til at stoppe krampeanfald (anti-epileptika, som fx carbamazepin, pherphenazin,
English: Severe nausea, diarrhoea, constipation and vomiting, sometimes requiring the use of anti-emetic and anti-diarrhoeal medicinal products, have been reported in patients treated with Farydak (see section 4.8).
Danish: Svær kvalme, diarré, obstipation og opkastning, som undertiden nødvendiggjorde brug af antiemetika eller lægemidler mod diarré, er blevet indberettet hos patienter, der blev behandlet med Farydak (se pkt.
English: Likewise ischaemic heart disease (including myocardial infarction and ischaemia) were reported in 4.5% of patients with ST-T depression and 4.8% of patients with T wave change and 2.7% of patients with neither of these ECG abnormalities.
Danish: Tilsvarende blev iskæmisk hjertelidelse (inklusive myokardieinfakt og iskæmi) indrapporteret for 4,5% af patienter med nedsat ST-T og 4,8% af patienter med T-bølge ændringer og 2,7% af patienter uden nogle af disse EKG-afvigelser.
English: Hyperglycaemia, dehydration, hypoalbuminaemia, fluid retention, hyperuricaemia, hypocalcaemia, hypomagnesaemia
Danish: Hyperglykæmi, dehydrering, hypoalbuminæmi, væskeretention, hyperurikæmi, hypokalciæmi, hypomagnesiæmi
English: SGOT (AST) levels
Danish: Bilirubin-niveau SGOT (ASAT)niveauer
English: Grade 3 neutropenia (<1.0-0.5 x 109/l)
Danish: Grad 3 neutropeni (<1,0-0,5 x 109/l)
English: Sexually active men taking Farydak and their female partners should use a highly effective method of contraception during the man's treatment and for six months after his last dose of Farydak.
Danish: Seksuelt aktive mænd, der tager panobinostat, og deres kvindelige partnere skal anvende yderst effektiv kontraception under mandens behandling og i seks måneder efter hans sidste dosis Farydak.
English: Cycles 9-16 (3-week cycles)
Danish: Cyklus 9-16 (3-ugers cyklusser)
English: Due to its cytostatic/cytotoxic mode of action, panobinostat can influence the quality of sperm formed during treatment.
Danish: På grund af dets cytostatiske/cytotoksiske virkning kan Farydak påvirke kvaliteten af den sæd, der dannes under behandlingen.
English: ECG (electrocardiogram) abnormalities have been reported in patients treated with panobinostat + bortezomib + dexamethasone, mainly involving ST-T depression (21.7%) and T wave changes (39.6%).
Danish: Der er blevet indberettet EKG- (elektrokardiogram) afvigelser hos patienter behandlet med panobinostat + bortezonib + dexamethason, der hovedsageligt involverer nedsat ST-T (21,7%) og Tbølge ændringer (39,6%).
English: Grade 4 neutropenia (<0.5 x 109/l) or febrile neutropenia (<1.0 x 109/l and fever ≥38.5°C)
Danish: Grad 4 neutropeni (<0,5 x 109/l) eller febril neutropeni (<1,0 x 109/l og feber
English: A total of 768 patients were randomised in a 1:1 ratio to either the panobinostat + bortezomib + dexamethasone (n=387) or the placebo + bortezomib + dexamethasone (n=381) arm, stratified by prior use of bortezomib [Yes (n=336 (43.8%)), No (n=432 (56.3%))] and number of prior lines of anti-myeloma therapy [1 prior line (n=352 (45.8%)), 2 to 3 prior lines (n=416 (54.2%))].
Danish: I alt 768 patienter blev randomiseret i forholdet 1:1 til enten behandlingsarmen med panobinostat + bortezomib + dexamethason (n=387) eller med placebo + bortezomib + dexamethason (n=381), stratificeret efter tidligere brug af bortezomib [Ja (n=336 (43,8 %)), Nej (n=432 (56,3 %))] og antal tidligere anti-myelombehandlingslinjer [1 tidligere linje (n=352 (45,8 %)), 2 til 3 tidligere linjer (n=416 (54,2 %))].
English: - medicines used to treat HIV, such as ritonavir or saquinavir.
Danish: - medicin til behandling af HIV, som fx ritonavir eller saquinavir.
English: Farydak, in combination with bortezomib and dexamethasone, is indicated for the treatment of adult patients with relapsed and/or refractory multiple myeloma who have received at least two prior regimens including bortezomib and an immunomodulatory agent.
Danish: Farydak, er i kombination med bortezomib og dexamethason, indiceret til behandling af voksne patienter med recidiv og/eller refraktær myelomatose, som har modtaget mindst to forudgående behandlingsregimer, herunder med bortezomib og en immunmodulator.
English: Hypothyroidism events were reported in 8 of 381 patients treated with panobinostat + bortezomib + dexamethasone in Study D2308, of whom 2 required treatment.
Danish: Der er blevet rapporteret tilfælde af hypothyroidisme hos 8 ud af 381 patienter behandlet med panobinostat + bortezomib + dexamethason i studie D2308, hvoraf to krævede behandling.
English: Haemorrhage intracranial, syncope, tremor, dysgeusia
Danish: Intrakraniel blødning, synkope, tremor, dysgeusi
English: Study DUS71 was a two-stage, single-arm, open-label multicentre phase II study of oral panobinostat (20 mg) in combination with bortezomib (1.3 mg/m2) and dexamethasone (20 mg) in 55 patients with relapsed and refractory multiple myeloma, who were bortezomib-refractory and had received at least two prior lines of therapy.
Danish: Forsøg DUS71 var et enkeltarmet, ublindet, fase II-multicenterforsøg i to faser med oral panobinostat (20 mg) i kombination med bortezomib (1,3 mg/m2) og dexamethason (20 mg) hos 55 patienter med recidiverende og behandlingsrefraktær myelomatose, som var bortezomib-refraktære og havde modtaget mindst to forudgående behandlingslinjer.
English: At the first sign of abdominal cramping, loose stools or onset of diarrhoea, it is recommended that the patient be treated with an anti-diarrhoeal medicinal product (e.g. loperamide).
Danish: Ved første tegn på mavekramper, løs afføring eller begyndende diarré anbefales det, at patienten behandles med et lægemiddel mod diarré (f.eks. loperamid).
English: Rest period
Danish: Hvileperiode
English: CTC grade 3 or 4 haemorrhage was reported in 4.2% of patients, mostly commonly involving gastrointestinal haemorrhage.
Danish: Hæmoragi i CTC-grad 3 eller 4 blev indberettet hos 4,2 % af patienterne og for det meste gastrointestinal hæmoragi.
English: Table 6 Recommended starting dose modification for patients with hepatic impairment Grade of hepatic impairment*
Danish: Tabel 6 Anbefalet justering af startdosis for patienter med leverinsufficiens Leverinsufficiensg rad*
English: Resume at reduced dose
Danish: Genoptag med nedsat dosis
English: • vomiting, nausea, upset stomach, indigestion
Danish: • opkastning, kvalme, uro i maven, fordøjelsesbesvær
English: - check how well your thyroid and pituitary gland are working (by measuring your blood levels of thyroid hormones).
Danish: - kontrollere hvor godt din skjoldbruskkirtel og hypofyse virker (ved at måle niveauet af dine skjoldbruskkirtel-hormoner i blodet)
English: • sudden bleeding or bruising underneath the skin (signs of low level of blood platelets)
Danish: • pludselig blødning eller blodudtrædning under huden (tegn på et lavt antal blodplader)
English: Cycles 1-8 (3-week cycles)
Danish: Cyklus 1-8 (3-ugers cyklusser)
English: Adjustment of bortezomib dose should also be considered (see bortezomib SmPC and Table 6).
Danish: Justering af bortezomib-dosis skal også overvejes (se produktresuméet for bortezomib og tabel 6).
English: The baseline platelet count should be ≥100 x 109/l and the baseline absolute neutrophil count (ANC) ≥1.0 x 109/l.
Danish: Trombocyttallet ved baseline bør være ≥100 x 109/l og absolut neutrofiltal (ANC) ved baseline ≥1,0 x 109/l.
English: Push the Farydak capsule through the pocket on days 1, 3 and 5 of week 1 and days 8, 10 and 12 of week 2.
Danish: Tryk Farydak kapsler gennem blisterens hulrum på dag 1, 3 og 5 i uge 1 og dag 8, 10 og 12 i uge 2.
English: • feeling thirsty, low urine output, weight loss, dry flushed skin, irritability (signs of dehydration)
Danish: • tørst, lav urinmængde, vægttab, tør, rødmende hud, irritabilitet (tegn på dehydrering)