FrancophonIA/ELRC3.0 huggingface dataset:
English: Disturbance in attention, memory impairment, amnesia, cognitive disorder, mental impairment, psychomotor skills impaired, convulsion, coordination abnormal, tremor, lethargy, hypoaesthesia, nystagmus, dysgeusia, balance disorder, dysarthria, intention tremor, sedation ,
Maltese: Disturb flattenzjoni, indeboliment tal-memorja, amnesija, disturb konoxxottiv, indeboliment mentali, abbilitajiet psikomuturi indeboliti, konvulżjoni, koordinazzjo ni mhux normali, tregħid, letarġija, ipestesija, nistagmus, disgużja, disturb filbilanċ, disartrija, tregħid ma' moviment volontarju, sedazzjoni
English: Topiramate antagonized the ability of kainate to activate the kainate/AMPA (α -amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subtype of excitatory amino acid (glutamate) receptor, but had no apparent effect on the activity of N-methyl-Daspartate (NMDA) at the NMDA receptor subtype.
Maltese: Topiramate antagonizza labbiltà ta' kainate li jattiva s-sottoptip ta' riċettur li jistimula l-aċidu amminiku (glutamate), kainate/AMPA (α -amino-3-hydroxy-5-methylisoxazole-4-propionic acid) iżda ma' kellu l-ebda effett li jidher fuq l-attività ta' N-methyl-D-aspartate (NMDA) fis-sottotip tar-riċettur NMDA.
English: Monotherapy epilepsy
Maltese: Monoterapija għall-epilessija
English: In newly diagnosed patients, topiramate showed benefit in monotherapy in two (TOPMAT-EPMN-105 and TOPMAT-EPMN-106) out of the three studies conducted.
Maltese: F'pazjenti li jkunu għadhom kif ġew iddijanjostikati, topiramate wera benefiċċju fil-monoterapija fi tnejn (TOPMAT-EPMN-105 u TOPMAT-EPMN-106) mit-tliet studji li saru.
English: In patients with bipolar disorder, the pharmacokinetics of lithium were unaffected during treatment with topiramate at doses of 200 mg/day; however, there was an observed increase in systemic exposure (26% for AUC) following topiramate doses of up to 600 mg/day.
Maltese: F'pazjenti b'disturb bipolari, ilfarmakokinetika ta' lithium ma kinitx affettwata waqt kura b'topiramate f'dożi ta' 200 mg/jum; madankollu, kien hemm żieda osservata fl-esponiment sistemiku (26% għall-AUC) wara li ngħataw dożi ta' topiramate sa 600 mg/jum.
English: Indication Migraine Prophylaxis
Maltese: Indikazzjoni il-Profilassi tal-Emigranja
English: The results of this study indicated that metformin mean Cmax and mean AUC0-12h increased by 18% and 25%, respectively, while mean CL/F decreased 20% when metformin was co-administered with topiramate.
Maltese: Ir-riżultati ta' dan l-istudju indikaw li lmedja tas-Cmax u l-medja tal-AUC0-12h ta' metformin żdiedu bi 18% u 25% rispettivament filwaqt li lCL/F naqqset b'20% meta metformin ingħata flimkien ma' topiramate.
English: b a % values are the changes in treatment mean Cmax or AUC with respect to monotherapy ↔ = No effect on Cmax and AUC (≤ 15% change) of the parent compound NS = Not studied *DEA = des acetyl diltiazem, DEM = N-demethyl diltiazem b Flunarizine AUC increased 14% in subjects taking flunarizine alone.
Maltese: monoterapija ↔ = L-ebda effett fuq is-Cmax u l-AUC (bidla ta' ≤ 15%) tas-sustanza oriġinali NS = Ma Ġiex Studjat *DEA = des acetyl diltiazem, DEM = N-demethyl diltiazem b L-AUC ta' flunarizine żdiedet b'14% f'individwi li kienu qed jieħdu flunarizine waħdu.
English: The investigation of topiramate as monotherapy in the paediatric population related to a minority (~20%) of the patients evaluated in the randomized controlled studies of topiramate monotherapy who were children (≤16 years of age).
Maltese: L-investigazzjoni ta' topiramate bħala monoterapija fil-popolazzjoni pedjatrika kienet relatata ma' minorità (~20%) tal-pazjenti evalwati fl-istudji kkontrollati maħdumin fuq bażi każwali talmonoterapija b'topiramate li kienu tfal (età ta' ≤16-il sena).
English: Topiramate Concentrationa
Maltese: Konċentrazzjonia ta' Topiramate
English: When topiramate was added to existing risperidone (1-6 mg/day) treatment, adverse events were reported more frequently than prior to topiramate (250-400 mg/day) introduction (90% and 54 % respectively).
Maltese: Meta topiramate żdied ma' kura b'risperidone (1-6 mg/jum) li kienet qed tittieħed diġà, kienu rrappurtati każijiet avversi b'mod aktar frekwenti minn qabel ma żdied topiramate (250-400 mg/jum) (90% u 54 % rispettivament).
English: Based on the recovery of radioactivity from the urine the mean extent of absorption of a 100 mg oral dose of 14C-topiramate was at least 81%.
Maltese: Fuq bażi tal-ġbir lura tiegħu minn radjuattività fl-awrina l-medja ta' kemm tiġi assorbita doża orali ta' 100 mg 14C-topiramate kienet ta' mill-anqas 81%.
English: Mania, anorgasmia, panic disorder, disturbance in sexual arousal, feeling of despair*, orgasm abnormal, hypomania, orgasmic sensation decreased
Maltese: Manija, anorgasmija, disturb ta' paniku, disturb fil-passjoni sesswali, tħoss disprament*, orgażmu mhux normali, ipomanija, tnaqqis fissensazzjoni orgażmika,
English: Janssen-Cilag Kft. - HU 2045 Törökbálint Tó park, Hungary
Maltese: Törökbálint Tó park, L-Ungerija
English: Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not take this medication.
Maltese: Pazjenti bi problemi ereditarji rari ta' intolleranza għal galactose, defiċjenza talLapp lactase jew malassorbiment tal-glucose-galactose m'għandhomx jieħdu din il-mediċina.
English: In addition, topiramate inhibits some isoenzymes of carbonic anhydrase.
Maltese: Huwa wkoll inibitur ta' xi isożimi ta' carbonic anhydrase.
English: Concomitant administration of Topamax and alcohol or other CNS depressant medicinal products has not been evaluated in clinical studies.
Maltese: Amministrazzjoni konkomitanti ta' Topamax u alkoħol jew prodotti mediċinali oħra li jiddepressaw is-CNS ma ġewx evalwati fi provi kliniċi.
English: A decrease in Topamax (topiramate) dosage may be required if clinically indicated.
Maltese: Tnaqqis fid-doża ta' Topamax (topiramate) tista' tinħtieġ jekk huwa klinikament indikat.
English: UAB Johnson & Johnson - LT Šeimyniškių g.1A, LT-09312 Vilnius,
Maltese: UAB Johnson & Johnson - LT Šeimyniškių g.1A, LT-09312 Vilnius, Il
English: UAB Johnson & Johnson Šeimyniškių g. 1A, LT-09312 Vilnius, Lithuania
Maltese: UAB Johnson & Johnson Šeimyniškių g. 1A, LT-09312 Vilnius, IlLitwanja
English: The maximum weekly incremental dose titration has been amended to 50mg/day, as opposed to the 100mg/day.
Maltese: Titrazzjoni tad-doża inkrimentali massima ta' kull ġimgħa ġiet emendata għal 50 mg kuljum, kontra dik ta' 100 mg kuljum.
English: Topamax gélules 15 mg 15 milligram(s)
Maltese: Topamax gélules 15 mg 15 milligramma
English: Each metabolite represents less than 3% of the total radioactivity excreted following administration of 14C-topiramate.
Maltese: Kull metabolit jirrapreżenta anqas minn 3% tar-radjuattività totali mneħħija wara l-għoti ta' 14C-topiramate.
English: A drug-drug interaction study conducted in patients with type 2 diabetes evaluated the steady-state pharmacokinetics of glyburide (5 mg/day) alone and concomitantly with topiramate (150 mg/day).
Maltese: Studju ta' azzjoni reċiproka bejn żewġ mediċini li sar f'pazjenti b'dijabete tat-tip 2 evalwa ilfarmakokinetika ta' glyburide (5 mg/jum) waħdu u flimkien ma' topiramate (150 mg/jum) fl-istat fiss.
English: Effects of Topamax on other antiepileptic medicinal products
Maltese: Effetti ta' Topamax fuq prodotti mediċinali oħra kontra l-epilessija
English: Topamax 15 mgGranulat in Kapseln granuals in capsule
Maltese: Topamax 15 mgGranulat in Kapseln
English: Topamax 25 mgGranulat in Kapseln granuals in capsule
Maltese: Topamax 25 mgGranulat in Kapseln
English: • birth control pills.
Maltese: • pilloli tal-kontroll tat-twelid.
English: TOPAMAX 100 mg tabs 100 milligram(s)
Maltese: TOPAMAX 100 mg tabs 100 milligramma
English: Anhidrosis, hypoaesthesia facial, urticaria, erythema, pruritus generalised, rash macular, skin discolouration, dermatitis allergic, swelling face
Maltese: Anidrożi, ipestesija talwiċċ, urtikarja, eritema, ħakk mifrux, raxx makluari, telf ta' kulur tal-ġilda, dermatite allerġika, nefħa fil-wiċċ
English: In mice, fetal weights and skeletal ossification were reduced at 500 mg/kg/day in conjunction with maternal toxicity.
Maltese: Fil-ġrieden, piżijiet tal-feti u ossifikazzjoni skeletrika tnaqqsu b'500 mg/kg/jum flimkien ma' tossiċità tal-omm.
English: Conditions or therapies that predispose to acidosis (such as renal disease, severe respiratory disorders, status epilepticus, diarrhoea, surgery, ketogenic diet, or certain medicinal products) may be additive to the bicarbonate lowering effects of topiramate.
Maltese: Kundizzjonijiet jew kuri li jippredisponu għal aċidożi (bħal mard tal-kliewi, disturbi respiratorji qawwija, status epilepticus, dijarea, kirurġija, dieta ketoġenika, jew ċerti prodotti mediċinali) jistgħu jżidu ma' l-effett ta' topiramate li jnaqqas il-bikarbonat.
English: Studies in mice receiving concomitant administration of topiramate and carbamazepine or phenobarbital showed synergistic anticonvulsant activity, while combination with phenytoin showed additive anticonvulsant activity.
Maltese: Studji fil-ġrieden li kienu qed jirċievu topiramate mogħti flimkien ma' carbamazepine jew phenobarbital, urew attività sinerġetika kontra l-konvulżjonijiet, filwaqt li flimkien ma' phenytoin intweriet attività addittiva kontra l-konvulżjonijiet.
English: The most common ADRs (those with an incidence of >5% and greater than that observed in placebo in at least 1 indication in double-blind controlled studies with topiramate) include: anorexia, decreased appetite, bradyphrenia, depression, expressive language disorder, insomnia, coordination abnormal, disturbance in attention, dizziness, dysarthria, dysgeusia, hypoesthesia, lethargy, memory impairment, nystagmus, paresthesia, somnolence, tremor, diplopia, vision blurred, diarrhoea, nausea, fatigue, irritability, and weight decreased.
Maltese: L-aktar ADRs komuni (dawk b'inċidenza ta' >5% u aktar minn dak li ġie osservat bi plaċebo f'millanqas indikazzjoni waħda fi studji double-blind b'topiramate) jinkludu: anoressija, tnaqqis fl-aptit, bradifrenija, depressjoni, disturb ta' lingwaġġ espressiv, insomnija, koordinazzjoni mhux normali, disturb fl-attenzjoni, sturdament, disartrija, disgużja, ipestesija, telqa, indeboliment tal-memorja, nistagmus, parestesija, ħedla tan-ngħas, tregħid, diplopja, vista mċajpra, dijarea, tqalligħ, għeja kbira, irritabilità, u tnaqqis fil-piż.
English: TOPAMAX 200 mg tabs 200 milligram(s)
Maltese: TOPAMAX 200 mg tabs 200 milligramma
English: Weight increased*
Maltese: Nażofarinġite *
English: A 15% decrease in the AUCτ,ss of pioglitazone with no alteration in Cmax,ss was observed.
Maltese: Ġie osservat tnaqqis ta' 15% fl- AUCτ,ss ta' pioglitazone mingħajr l-ebda tibdil fis-Cmax,ss.
English: Face oedema, calcinosis
Maltese: Edima filwiċċ, kalċinożi
English: Nutritional supplementation
Maltese: Supplimentar ta' nutrizzjoni
English: The recommended total daily dose of Topamax (topiramate) as adjunctive therapy is approximately 5 to 9 mg/kg/day in two divided doses.
Maltese: Id-doża totali ta' Topamax (topiramate) rakkommandata li tittieħed kuljum bħala kura miżjuda hija bejn wieħed u ieħor minn 5 sa 9 mg/kg/jum maqsuma f'darbtejn.
English: Pizotifen Diltiazem25% decrease in AUC of diltiazem and 18% decrease in DEA, and ↔ for DEM*
Maltese: Pizotifen Diltiazem tnaqqis ta' 25% fl-AUC ta' diltiazem u tnaqqis ta' 18% fidDEA, u ↔ għal DEM*
English: About 300 patients between the age of 6 and 16 years old have been included in the clinical development of topiramate as monotherapy.
Maltese: Madwar 300 pazjent ta' età bejn is-6 u s16-il sena ġew inklużi fl-iżvilupp kliniku ta' topiramate bħala monoterapija.
English: Arthralgia, muscle spasms, myalgia, muscle twitching, muscular weakness, musculoskeletal chest pain
Maltese: Artralġja, spażmi filmuskoli, mijalġja, kontrazzjoni fil-muskoli, dgħjufija filmuskoli, uġigħ muskoluskel etrali fissider
English: Topamax 25 mg Kapseln 25 milligram(s)
Maltese: Topamax 25 mg Kapseln 25 milligramma
English: The plasma and renal clearance of topiramate are decreased in patients with impaired renal function (CLCR ≤ 60 ml/min), and the plasma clearance is decreased in patients with end-stage renal disease.
Maltese: It-tneħħija ta' topiramate mill-plasma u mill-kliewi hija mnaqqsa f'pazjenti b'indeboliment tal-kliewi (CLCR ≤ 60 ml/min), u t-tneħħija mill-plasma hija mnaqqsa f'pazjenti b'mard tal-kliewi tal-aħħar fażi.
English: TOPAMAX 25 mg tabs 25 milligram(s)
Maltese: TOPAMAX 25 mg tabs 25 milligramma
English: Approximately 66% of a dose of 14C-topiramate was excreted unchanged in the urine within four days.
Maltese: Bejn wieħed u ieħor 66% tad-doża ta' 14C-topiramate tneħħiet mhux mibdula fl-awrina fi żmien 4 ijiem.
English: Topamax 50 mg Kapseln 50 milligram(s)
Maltese: Topamax 50 mg Kapseln 50 milligramma
English: Topamax 50 mgGranulat in Kapseln granuals in capsule
Maltese: Topamax 50 mgGranulat in Kapseln
English: • if you are allergic (hypersensitive) to topiramate or any of the other ingredients of Topamax (listed in section 6).
Maltese: • jekk inti allerġiku (tbati minn sensittività eċċessiva għal topiramate jew għal xi sustanza oħra ta' Topamax (elenkati f'sezzjoni 6).
English: UAB Johnson & Johnson - LT Šeimyniškių g.1A, LT-09312 Vilnius, Lithuania
Maltese: UAB Johnson & Johnson - LT Šeimyniškių g.1A, LT-09312 Vilnius, IlLitwanja
English: The recommended total daily dose of approximately 5 - 9 mg/kg/day in two divided doses as adjunctive therapy in the paediatric population (children aged 2 years and above) was endorsed by the CHMP.
Maltese: Id-doża totali ta' kuljum rakkomandata ta' madwar 5 - 9 mg/kg/kuljum f'żewġ dożi diviżi bħala terapija aġġuntiva fil-popolazzjoni pedjatrika (tfal ta' età ta' sentejn u akbar) ġiet approvata millCHMP.
English: Seizures associated with Lennox-Gastaut syndrome (LGS) The use of topiramate as add-on therapy in patients (adults and paediatrics) with LGS treated with up to 2 AEDs was supported by only one, controlled, rather short study.
Maltese: Attakki assoċjati mas-sindrome ta' Lennox-Gastaut (LGS) L-użu ta' topiramate bħala terapija aġġuntiva f'pazjenti (adulti u pedjatriċi) b'LGS ikkurati b'massimu ta' 2 AEDs ġie appoġġjat bi studju wieħed biss li kien ikkontrollat u pjuttost qasir.
English: A contraindication for the use of topiramate for the indication of migraine prophylaxis in pregnancy and in women of childbearing potential if not using effective methods of contraception has been included in the SPC in sections 4.3 and 4.6.
Maltese: Kontraindikazzjoni għall-użu ta' topiramate għall-indikazzjoni tal-profilassi tal-emigranja matul ittqala u f'nisa ta' età li fiha jista' jkollhom it-tfal jekk ma jkunux qegħdin jużaw metodi effikaċi ta' kontraċezzjoni ġiet inkluża fl-SPC fis-sezzjonijiet 4.3 u 4.6.
English: There is undoubtedly statistically significant evidence of efficacy seen in the paediatric population as a whole to support the adjunctive therapy indication in children with POS, PGTS, or LGS seizure types.
Maltese: Mingħajr dubju ta' xejn, hemm evidenza statistikament sinifikanti ta' effikaċja li tidher fil-popolazzjoni pedjatrika in ġenerali li tappoġġa t-terapija aġġuntiva fit-tfal b'tipi ta' attakki POS, PGTS, jew LGS.
English: Topamax gélules 25 mg 25 milligram(s)
Maltese: Topamax gélules 25 mg 25 milligramma
English: Because the antiepileptic profile of topiramate differs markedly from that of the benzodiazepines, it may modulate a benzodiazepine-insensitive subtype of GABAA receptor.
Maltese: Minħabba li l-profil kontra l-epilessija ma jaqbilx b'mod ċar ma' dak tal-benzodiazepines, huwa jista' jimmodula sottotip ta' riċettur ta' GABAA insensittiv għal benzodiazepine.
English: TOPAMAX 50 mg tabs 50 milligram(s)
Maltese: TOPAMAX 50 mg tabs 50 milligramma
English: In humans, the major route of elimination of unchanged topiramate and its metabolites is via the kidney (at least 81% of the dose).
Maltese: Fil-bnedmin, ir-rotta prinċipali ta' eliminazzjoni ta' topiramate mhux mibdul u l-metaboliti tiegħu hija permezz tal-kilwa (mill-anqas 81% tad-doża).
English: Janssen-Cilag NV - BE Roderveldlaan 1 2600 Berchem, Belgium
Maltese: Il-Lussemburgu Janssen-Cilag NV - BE Roderveldlaan 1 2600
English: Vertigo, tinnitus, ear pain
Maltese: Vertigini, tinnitus, uġigħ filwidnejn
English: Children, however, have a higher clearance and a shorter elimination half-life.
Maltese: Madankollu t-tfal għandhom tneħħija ogħla u half-life ta' eliminazzjoni iqsar.
English: Lithium levels should be monitored when co-administered with topiramate.
Maltese: Livelli ta' lithium għandhom jiġu mmonitorjati meta jingħata flimkien ma' topiramate.
English: Topiramate is only weakly effective in blocking clonic seizures induced by the GABAA receptor antagonist, pentylenetetrazole.
Maltese: Topiramate huwa effettiv biss b'mod dgħajjef fl-imblukkar ta' aċċessjonijiet clonic indotti mill-antagonist tar-riċettur GABAA, pentylenetetrazole.
English: Topamax gélules 50 mg 50 milligram(s)
Maltese: Topamax gélules 50 mg 50 milligramma
English: Following oral administration of 100 mg topiramate to healthy subjects, a mean peak plasma concentration (Cmax) of 1.5 µg/ml was achieved within 2 to 3 hours (Tmax).
Maltese: Wara l-għoti mill-ħalq ta' 100 mg topiramate lill-individwi b'saħħithom, il-medja tal-ogħla konċentrazzjonijiet fil-plasma (Cmax) ta' 1.5 µg/ml inkisbet fi żmien sagħtejn sa 3 sigħat (Tmax).
English: Adjunctive therapy for epilepsy in children and adults The proposed indication of adjunctive therapy is approved in all of 29 countries involved in the Article 30 procedure.
Maltese: L-indikazzjoni proposta tat-terapija aġġuntiva hija approvata fid-29 pajjiż kollha li huma involuti filproċedura tal-Artikolu 30.
English: In animal studies, topiramate exhibits anticonvulsant activity in rat and mouse maximal electroshock seizure (MES) tests and is effective in rodent models of epilepsy, which include tonic and absence-like seizures in the spontaneous epileptic rat (SER) and tonic and clonic seizures induced in rats by kindling of the amygdala or by global ischemia.
Maltese: Fi studji fl-annimali, topiramate wera attività kontra l-konvulżjonijiet f'testijiet ta' aċċessjonijiet minn xokk elettriku massimu (MES) fil-far u l-ġurdien u huwa effettiv fil-mudelli ta' annimali gerriema blepilessija, li jinkludu aċċessjonijiet tonic u aċċessjonijiet jixbħu lill-aċċessjonijiet absence fil-far spontanjament epilettiku (SER) u aċċessjonijiet tonic u clonic ikkaġunati fil-firien bi stimulu tattunsilli jew b'iskemija globali.
English: Adjunctive Therapy for Primary Generalized Tonic-Clonic (PGTC) Seizures in Adults and Children Two studies YTC and YTC-E, explored the efficacy of topiramate as adjunctive therapy in primary generalised tonic-clonic (PGTC) seizures patients.
Maltese: Terapija Aġġuntiva għall-Attakki Toniċi-Kloniċi Ġeneralizzati Primarji (Primary Generalized Tonic-Clonic - PGTC) fl-Adulti u fit-Tfal
English: Following administration of multiple doses of 50 mg and 100 mg of topiramate twice a day, the mean plasma elimination half-life was approximately 21 hours.
Maltese: Wara ħafna dożi ta' topirmate ta' 50 mg u 100 mg mogħtija darbtejn kuljum, il-half-life medja ta' eliminazzjoni millplasma kienet ta' bejn wieħed u ieħor 21 siegħa.
English: Suicidal ideation, suicide attempt, hallucination, psychotic disorder, hallucination auditory, hallucination visual, apathy, lack of spontaneous speech, sleep disorder, affect lability, libido decreased, restlessness, crying, dysphemia, euphoric mood, paranoia, perseveration, panic attack, tearfulness, reading disorder, initial insomnia, flat affect, thinking abnormal, loss of libido, listless, middle insomnia, distractibility, early morning awakening, panic reaction, elevated mood
Maltese: Ħsibijiet ta' suwiċidju, attentat ta' suwiċidju, alluċinazzjoni, disturb psikotiku, alluċinazzjoni tassmigħ, alluċinazzjoni viżwali, apatija, nuqqas ta' taħdit spontanju, disturb fl-irqad, affettazzjoni ta' nuqqas ta' stabbilità emozzjonali, libido mnaqqas, nuqqas ta' kwiet, biki, disfemija, burdata ewforika, paranoja, perseverazzjoni, attakk ta' paniku, tixrid ta' dmugħ, disturb fil-qari, insomnja fil-bidu tar-raqda, tnaqqis qawwi flespressività talemozzjoni, ħsibijiet mhux
English: Respiratory, thoracic and mediastinal disorders
Maltese: Disturbi respiratorji toraċiċi u medjastinali
English: There would appear to be a reduction in all measured parameters (Cmax, Tmax and AUC) for Ethinyl Estradiol associated with concomitant topiramate administration in the epilepsy study.
Maltese: Jidher li jista' jkun hemm tnaqqis fil-parametri kollha mkejla (Cmax, Tmax u AUC) għal Ethinyl Estradiol assoċjati ma' amministrazzjoni fl-istess ħin ta' topiramate flistudju tal-epilessija.
English: Overall, plasma clearance is approximately 20 to 30 ml/min in humans following oral administration.
Maltese: Globalment, tneħħija mill-plasma fil-bnedmin hija bejn wieħed u ieħor minn 20 sa 30 ml/min wara li jingħata mill-ħalq.
English: • are on a high fat diet (ketogenic diet)
Maltese: • qiegħed fuq dieta li fiha ħafna xaħmijiet (dieta ketoġenika)
English: This pharmacologic effect is much weaker than that of acetazolamide, a known carbonic anhydrase inhibitor, and is not thought to be a major component of topiramate's antiepileptic activity.
Maltese: Dan l-effett farmakoloġiku huwa ħafna anqas minn dak ta' acetazolamide, impeditur magħruf ta' carbonic anhydrase, u mhuwiex maħsub li huwa komponent ta' importanza fl-attivita kontra l-epilessija ta' topiramate.
English: The results of this study indicate that topiramate Cmax increased by 27% and AUC increased by 29% when HCTZ was added to topiramate.
Maltese: Ir-riżultati ta' dan l-istudju jindikaw li s-Cmax ta' topiramate żdiedet b'27% u l-AUC żdiedet b'29% meta HCTZ żdied ma' topiramate.
English: TOPAMAX MIGRÄNE 50 mg Hartkapseln
Maltese: MIGRÄNE 50 mg Hartkapseln
English: ”Adjunctive therapy in children aged 2 years and above, adolescents and adults with partial onset seizures with or without secondary generalization or primary generalized tonic-clonic seizures and for the treatment of seizures associated with Lennox-Gastaut syndrome.”
Maltese: “Terapija aġġuntiva fit-tfal ta' età ta' sentejn u aktar, fl-adoloxxenti u fl-adulti b'attakki parzjali f'daqqa bi jew mingħajr ġeneralizzazzjoni sekondarja jew attakki toniċi-kloniċi ġeneralizzati primarji u għat-trattament ta' attakki assoċjati mas-sindrome ta' Lennox-Gastaut.
English: TOPAMAX 200 tablets 200 milligram(s)
Maltese: TOPAMAX 200 tablets 200 milligramma
English: Topamax and associated names (see Annex I) 25 mg film-coated tablets Topamax and associated names (see Annex I) 50 mg film-coated tablets Topamax and associated names (see Annex I) 100 mg film-coated tablets Topamax and associated names (see Annex I) 200 mg film-coated tablets
Maltese: Topamax u ismijiet assoċjati miegħu (ara Anness I) pilloli ta' 25 mg miksijin b'rita Topamax u ismijiet assoċjati miegħu (ara Anness I) pilloli ta' 50 mg miksijin b'rita Topamax u ismijiet assoċjati miegħu (ara Anness I) pilloli ta' 100 mg miksijin b'rita Topamax u ismijiet assoċjati miegħu (ara Anness I) pilloli ta' 200 mg miksijin b'rita
English: Rarely, patients have experienced decreases to values below 10 mmol/l.
Maltese: B'mod rari, pazjenti esperjenzaw tnaqqis għal valuri anqas minn 10 mmol/l.
English: The recommended monotherapy dosage of 100 - 200 mg/day as the initial target dose and the maximum daily dose of 500mg/day in monotherapy in adults, and the initial target dose of 100 mg/day depending on clinical response in children aged 6 years and above was endorsed by the CHMP for use.
Maltese: Id-dożaġġ irrakkomandat għall-monoterapija ta' 100 - 200 mg kuljum bħala d-doża fil-mira inizjali u d-doża massima ta' kuljum ta' 500 mg kuljum fil-monoterapija għall-adulti, u d-doża fil-mira inizjali ta' 100 mg kuljum skont ir-reazzjoni klinika fit-tfal ta' sitt snin u aktar ġie rrakkomandat mill-CHMP għall-użu.
English: However, differences in AUC for the total active moiety between treatment with risperidone alone and combination treatment with topiramate were not statistically significant.
Maltese: Madankollu, differenzi fl-AUC għat-total tal-parti attiva bejn kura b'risperidone waħdu u kura flimkien ma' topiramate ma kinux statistikament sinifikanti.