FrancophonIA/ELRC3.0 huggingface dataset:
English: If your disease responds to Arsenic trioxide Accord, you will be given 4 additional treatment cycles of 20 doses given 5 days per week (followed by 2 days interruption) for 4 weeks followed by 4 weeks interruption.
Croatian: Svaki ciklus sastoji se od 20 doza koje se daju 5 dana u tjednu (nakon čega slijedi 2 dana pauze) tijekom 4 tjedna, nakon čega slijedi pauza od 4 tjedna.
English: • Newly diagnosed low-to-intermediate risk acute promyelocytic leukaemia (APL) (white blood cell count, ≤ 10 x 103/µl) in combination with all-trans-retinoic acid (ATRA)
Croatian: (broj bijelih krvnih stanica ≤ 10 x 103/µl) u kombinaciji sa sve-trans-retinoatnom kiselinom
English: After first opening Once opened the product should be used immediately.
Croatian: Lijek se mora upotrijebiti odmah nakon otvaranja.
English: Negative Positive Not evaluable
Croatian: Nepoznato* Nepoznato*
English: Respiratory, thoracic and mediastinal disorders
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja sindrom diferencijacije
English: Absent Present Not evaluable
Croatian: Ne može se procijeniti
English: In a phase 3, multicenter, noninferiority trial comparing all-trans-retinoic acid (ATRA) plus chemotherapy with ATRA plus arsenic trioxide in newly diagnosed low-to-intermediate risk APL patients (Study APL0406; see also section 5.1), serious adverse reactions including hepatic toxicity, thrombocytopenia, neutropenia and QTc prolongation were observed in patients treated with arsenic trioxide.
Croatian: U multicentričnom ispitivanju neinferiornosti faze 3 u kojem je uspoređena primjena kombinacije sve-trans-retinoatne kiseline (ATRA) i kemoterapije s primjenom kombinacije ATRA-e i arsenovog trioksida u novodijagnosticiranih bolesnika s APL-om niskog do srednjeg rizika (ispitivanje APL0406;
English: Fertility studies have not been conducted with arsenic trioxide.
Croatian: S arsenovim trioksidom nisu provedena ispitivanja plodnosti.
English: Confusional state
Croatian: Psihijatrijski poremećaji konfuzno stanje
English: Common (may affect up to 1 in 10 people): - reduction in blood cell counts (platelets, red and/or white blood cells), increased white blood cells - chills, increased weight - a fever due to an infection and low levels of white blood cells, herpes zoster infection - chest pain, bleeding in the lung, hypoxia (low oxygen level), collection of fluid around the heart or the lung, low blood pressure, abnormal heart rhythm - fit, joint or bone pain, inflammation of the blood vessels - increased sodium or magnesium, ketones in the blood and urine (ketoacidosis), renal function tests abnormal, kidney failure - stomach (abdominal) ache - redness of the skin, swollen face, blurred vision
Croatian: - vrućica zbog infekcije i niskih razina bijelih krvnih stanica, infekcija herpesom zosterom - bolovi u prsima, krvarenje u plućima, hipoksija (niska razina kisika), nakupljanje tekućine oko srca ili pluća, nizak krvni tlak, poremećeni srčani ritam
English: Arsenic trioxide Accord contains sodium:
Croatian: Lijek Arsenov trioksid Accord sadrži natrij.
English: In newly diagnosed patients, with low to intermediate risk APL, QTc prolongation was observed in 15.6 %.
Croatian: Među novodijagnosticiranim bolesnicima s APL-om niskog do srednjeg rizika, njih 63,2% razvilo je
English: Dilution of Arsenic trioxide Accord
Croatian: Razrjeđivanje lijeka Arsenov trioksid Accord
English: Pyrexia
Croatian: RMP-a.
English: Pneumonitis
Croatian: FARMACEUTSKI
English: Oedema
Croatian: Prisutno
English: Lymphopenia
Croatian: BOČICA
English: This event is called extravasation.
Croatian: Taj se događaj naziva ekstravazacija.
English: The infusion will last 1-2 hours.
Croatian: Infuzija će trajati 1-2 sata.
English: • Infection (after an operation or other infections)
Croatian: • Infekcija (nakon operacije ili druge infekcije)
English: Both of these effects are expected for this class of compound.
Croatian: Oba ova učinka očekivana su za ovu skupinu spojeva.
English: Powder and solvent: 3 years.
Croatian: Prašak i otapalo: 3 godine.
English: CTC grade 3-4
Croatian: CTC stupanj 3-4
English: If you receive more Savene than you should
Croatian: Ako primite više lijeka Savene nego što ste trebali
English: It is a serious complication as it can cause severe tissue damage.
Croatian: To je ozbiljna komplikacija jer može izazvati teško oštećenje tkiva.
English: Date of latest renewal: 18 July 2011
Croatian: Datum posljednje obnove odobrenja: 18. srpnja 2011.
English: All adverse reactions have been rapidly reversible.
Croatian: Sve nuspojave su brzo reverzibilne.
English: Total urinary recovery of unchanged dexrazoxane is 34-60 %.
Croatian: Ukupni postotak urinarnog povrata nepromijenjenog deksrazoksana je 34-60%.
English: • Changes in liver function (these may be seen in test results)
Croatian: • Promjene u funkciji jetre (mogu se vidjeti u nalazima pretraga)
English: In both studies the dosage regimen was the same.
Croatian: U oba je ispitivanja režim doziranja bio isti.
English: Treatment Day 2 and Day 3 should start at the same hour (+/- 3 hours) as Day 1.
Croatian: Liječenje drugog i trećeg dana treba započeti u isti sat (+/- 3 sata) kao i prvi dan.
English: Some side effects can be serious and need immediate medical attention.
Croatian: Neke nuspojave mogu biti ozbiljne i zahtijevaju trenutnu medicinsku pažnju.
English: Your doctor will calculate your body surface area in square meter (m2) to determine the dose you should receive.
Croatian: Liječnik će izračunati Vašu površinu tijela u četvornim metrima (m2) kako bi odredio dozu koju trebate primati.
English: Savene will not be used again at the time of your next anthracycline cycle, except if extravasation occurs again.
Croatian: Savene se neće ponovno davati prilikom Vašeg sljedećeg ciklusa antraciklina, osim ako ponovno dođe do ekstravazacije.
English: The dose will depend on your height, weight and kidney function.
Croatian: Doza ovisi o Vašoj visini, težini i funkciji bubrega.
English: None of the patients required surgical intervention.
Croatian: Nitko od bolesnika nije trebao kiruršku intervenciju.
English: The toxicity in combination with doxorubicin was additive and not synergistic.
Croatian: Toksičnost u kombinaciji s doksorubicinom bila je aditivna, a ne sinergistička.
English: It contains no antibacterial preservative.
Croatian: Ne sadrži antibakterijske konzervanse.
English: Treatment with Savene had to be started within 6 hours from the incident and was repeated after 24 and 48 hours.
Croatian: Liječenje lijekom Savene je moralo započeti unutar 6 sati od nezgode te je bilo ponovljeno nakon 24 i 48 sati.
English: • Weight loss, loss of appetite
Croatian: • Gubitak težine, gubitak apetita
English: Only one of the 36 patients required surgery.
Croatian: Samo je jedan od 36 bolesnika trebao kiruršku intervenciju.
English: If you get any of the above symptoms, seek medical advice immediately.
Croatian: Ako imate bilo koji od gore navedenih simptoma, odmah potražite liječničku pomoć.
English: What Savene is and what it is used for What you need to know before you use Savene How to use Savene
Croatian: Što je Savene i za što se koristi Što morate znati prije nego počnete primjenjivati Savene
English: • Other live attenuated vaccines: risk of systemic, possible fatal disease.
Croatian: • drugim živim oslabljenim cjepivima: rizik od sistemske, moguće smrtonosne bolesti.
English: The first infusion should be initiated as soon as possible, within the first six hours after the accident.
Croatian: Prvu infuziju treba dati što je moguće prije, unutar prvih šest sati od nezgode.
English: The elimination half-life of the two-ring opened metabolite ADR-925 is not given in literature.
Croatian: Poluvrijeme eliminacije otvorenog dvoprstenastog metabolita ADR-925 nije navedeno u literaturi.
English: Children and adolescents Savene should not be administered to children below the age of 18 years.
Croatian: Savene se ne smije davati djeci mlađoj od 18 godina.
English: Based on a limited number of patients, interindividual variability calculated as the coefficient of variation (CV %) was estimated to be approximately 30 % for the main pharmacokinetic parameters.
Croatian: Temeljeno na ograničenom broju bolesnika, interindividualna varijabilnost izračunata kao koeficijent varijacije (CV %) procijenjena je na otprilike 30% glavnih farmakokinetičkih parametara.
English: Volume of distribution is independent of dose.
Croatian: Volumen distribucije neovisan je o dozi.
English: - In order to avoid the potential contamination of the medicine by microbes, the product should be used immediately.
Croatian: - Kako bi se izbjegla potencijalna kontaminacija lijeka mikrobima, lijek treba odmah upotrijebiti.
English: This is equivalent to 81% of the recommended maximum daily dietary intake of sodium for an adult.
Croatian: To odgovara 81 % preporučenog maksimalnog dnevnog unosa natrija za odraslu osobu.
English: Inter- and intra-individual pharmacokinetic variabilities have not been studied systematically.
Croatian: Inter- i intraindividualne farmakokinetičke varijabilnosti nisu sustavno ispitivane.
English: Use of gloves and other protective clothing to prevent skin contact is recommended.
Croatian: Preporučuje se upotreba rukavica i ostale zaštitne odjeće za sprječavanje kontakta s kožom.
English: The apparent effects were greater during chronic than acute administration.
Croatian: Vidljivi učinci bili su veći pri kroničnoj nego akutnoj primjeni.
English: Overall, the most commonly received anthracycline was epirubicin (56 % of the patients).
Croatian: Općenito uzevši, najčešći antraciklin koji su primili bio je epirubicin (56% bolesnika).
English: It is important that you read the entire content of this procedure prior to the preparation of Savene.
Croatian: Važno je pročitati sav sadržaj ovog postupka prije pripremanja lijeka Savene.
English: - Myelosuppressive medicines (decrease production of red, white, or coagulating blood cells).
Croatian: - Mijelosupresivne lijekove (smanjuju proizvodnju crvenih, bijelih ili koagulacijskih krvnih stanica).
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby ask your doctor for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego uzmete ovaj lijek.
English: • Blood clot in the vein, usually in an arm or leg
Croatian: • Krvni ugrušak u veni, obično u ruci ili nozi
English: There is insufficient data available to draw any definite conclusions regarding intrinsic pharmacokinetic factors such as age, gender, race and weight.
Croatian: Nema dovoljno dostupnih podataka temeljem kojih bi se utvrdili unutarnji farmakokinetički faktori kao što su starosna dob, spol, rasa i težina.
English: Savene is supplied as:
Croatian: Savene se isporučuje kao:
English: Eighteen were evaluable for efficacy and safety and a further five patients were evaluable for toxicity only.
Croatian: U osamnaest bolesnika su se mogle procijeniti djelotvornost i sigurnost, a u preostalih pet mogla se je procijeniti samo toksičnost.
English: If you are at risk of high potassium levels in your blood, your doctor will monitor this.
Croatian: Ako kod Vas postoji rizik od visoke razine kalija u krvi, Vaš liječnik će to nadzirati.
English: • Reduction in any of your senses (sight, smell, hearing, touch, taste)
Croatian: • Slabljenje bilo kojeg osjeta (vid, njuh, sluh, dodir, okus)
English: A number of published reports comprising more than 1000 patients have demonstrated a uniform pattern of dose dependent adverse reactions.
Croatian: Brojna objavljena izvješća koja obuhvaćaju više od 1000 bolesnika pokazala su uniforman uzorak ovisnosti nuspojava o dozi.
English: < PC: {number} [product code]
Croatian: PC: {broj} [oznaka lijeka]
English: Inhibition of topoisomerase II.
Croatian: Inhibicija topoizomeraze II.
English: Dexrazoxane has two major mechanisms of action:
Croatian: Deksrazoksan ima dva glavna mehanizma djelovanja:
English: There is limited information about the effect of Savene on fertility - if you have a concern about this speak to you doctor.
Croatian: Postoje ograničene informacije o učinku lijeka Savene na plodnost: u slučaju zabrinutosti obratite se liječniku.
English: Savene infusion will be given at the same time every day of your treatment.
Croatian: Infuzija lijeka Savene bit će dana u isto vrijeme svaki dan Vašeg liječenja.
English: Very common (≥1/10) Common (≥1/100 to <1/10) Uncommon (≥1/1,000 to <1/100) Rare (≥1/10,000 to <1/1,000)
Croatian: Vrlo često (≥1/10) Često (≥1/100 i <1/10) Manje često (≥1/1000 i <1/100) Rijetko (≥1/10 000 i <1/1000)
English: • Inflammation of a blood vessel just under the skin, often with a small blood clot
Croatian: • Upala krvne žile odmah ispod kože, često uz mali krvni ugrušak
English: 36 patients were evaluable for efficacy.
Croatian: U 36 bolesnika se je mogla procijeniti djelotvornost.
English: For patients with a body surface area of more than 2 m2 the single dose should not exceed 2000 mg.
Croatian: U bolesnika površine tijela veće od 2 m2 jedna doza ne smije prekoračiti 2000 mg.
English: In both studies all patients had received anthracycline.
Croatian: U oba ispitivanja svi su bolesnici primili antraciklin.
English: The safety and efficacy of Savene in children below the age of 18 years have not been established and no data are available.
Croatian: Pedijatrijska populacija Sigurnost i djelotvornost lijeka Savene u djece mlađe od 18 godina nisu ustanovljeni i nema dostupnih podataka.
English: Due to the rarity of the condition only historical data could be used for comparison (demonstrating surgical rates of 35-50 %, in one country 100% in biopsy proven cases).
Croatian: Zbog male učestalosti navedenog stanja, za usporedbu su se mogli koristiti samo povijesni podaci (pokazujući stopu kirurških zahvata od 35-50%, u jednoj zemlji 100% slučajeva potvrđenih biopsijom).
English: Most anti-cancer medicines are administered intravenously (into a vein).
Croatian: Većina lijekova protiv raka daje se intravenski (u venu).
English: All items for preparation, administration or cleaning, including gloves, as well as liquid waste should be disposed of in accordance with local requirements.
Croatian: Sav pribor za pripremu, primjenu ili čišćenje, uključujući rukavice, kao i tekući otpad treba zbrinuti sukladno nacionalnim propisima.
English: Cooling procedures such as ice packs should have been removed from the area at least 15 minutes before the Savene administration in order to allow sufficient blood flow.
Croatian: Postupci hlađenja, kao što su ledeni oblozi, moraju biti uklonjeni s tog područja barem 15 minuta prije primjene lijeka Savene kako biste omogućili dostatan protok krvi.
English: Savene should not be administered if you are pregnant.
Croatian: Savene se ne smije primijeniti ako ste trudni.
English: The apparent volumes of distribution are 0.13-1.3 l/kg (median 0.49 l/kg).
Croatian: Prividni volumeni distribucije su 0,13-1,3 l/kg (medijan 0,49 l/kg).
English: 4.1 Before reconstitution and dilution: - Store below 25 °C.
Croatian: 4.1 Prije rekonstitucije i razrjeđivanja: - Čuvati na temperaturi ispod 25 °C.
English: If Savene comes into contact with the skin, the affected area should immediately be rinsed thoroughly with water.
Croatian: Ako Savene dođe u kontakt s kožom, obuhvaćeno područje odmah treba temeljito isprati vodom.
English: Tissue distribution is rapid, with the highest levels of unchanged parent compound and hydrolysed product appearing in liver and kidneys.
Croatian: Distribucija u tkivu je brza, s najvišim razinama nepromijenjenog ishodišnog spoja i hidroliziranog produkta koji se pojavljuju u jetri i bubrezima.
English: - Ciclosporin or tacrolimus (both treatments lower the body's immune system and are used to prevent organ rejection after an organ transplant).
Croatian: - Ciklosporin ili takrolimus (oba lijeka oslabljuju imunološki sustav tijela te se koriste za sprječavanje odbacivanja organa nakon presađivanja).
English: The pharmacokinetics of the metabolites is derived from a single study with five patients.
Croatian: Farmakokinetika metabolita je izvedena iz jednog ispitivanja na pet bolesnika.
English: This risk is increased in subjects who are already immunosuppressed by their underlying disease or by concomitant chemotherapy.
Croatian: Ovaj rizik je povećan kod osoba koje su već imunosuprimirane zbog svoje osnovne bolesti ili istodobne kemoterapije.
English: Pharmacokinetics in patients with extravasations
Croatian: Farmakokinetika u bolesnika s ektravazacijama
English: • Reactions at the site of injection (pain at the site, red, swollen or painful skin at the site or hardening of the skin at the site)
Croatian: • Reakcije na mjestu primjene injekcije (bol na tom mjestu, crvenilo kože, otečena ili bolna koža na tom mjestu ili otvrdnjavanje kože na tom mjestu)
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 4 hours at 2 to 8 °C.
Croatian: Ako se ne upotrijebi odmah, vrijeme i uvjeti čuvanja prije uporabe odgovornost su korisnika i ne bi trebali biti dulje od 4 sata pri temperaturi od 2 do 8 °C.
English: - During treatment with Savene the area where the extravasation has occurred will be examined on a regular basis and you will have blood tests taken regularly to check your blood cells.
Croatian: - Tijekom liječenja lijekom Savene područje gdje se pojavila ekstravazacija redovito će se pregledavati i redovito ćete raditi krvne pretrage radi provjere krvnih stanica.
English: - If you have liver problems, your doctor will monitor your liver function during treatment.
Croatian: - Ako imate problema s jetrom, liječnik će pratiti Vašu funkciju jetre tijekom liječenja.
English: The mean AUC0-24 values for day 1 and day 2 were comparable with each other, and the AUC0-last at day 3 was approximately half that of the first two days, suggesting that the pharmacokinetics of dexrazoxane are dose-dependent.
Croatian: Srednje vrijednosti za AUC0-24 za prvi dan i drugi dan bile su usporedive jedna s drugom, a AUC0-last trećeg dana bio je približno upola manji nego prva dva dana, što ukazuje na to da farmakokinetike deksrazoksana ovise o dozi.
English: From a microbiological point of view the product should be used immediately.
Croatian: S mikrobiološkog stajališta, lijek treba odmah upotrijebiti.
English: Treatment should be given once daily for 3 consecutive days.
Croatian: Lijek treba davati jednom dnevno, 3 uzastopna dana.
English: The systemic clearances were similar between day 1 (9.9 L/h ± 3.1) and day 2 (11.1 L/h ± 4.5), and did not differ from those reported in the literature.
Croatian: Sistemski klirens bio je sličan između prvog dana (9,9 l/h ± 3,1) i drugog dana (11,1 l/h ± 4,5) i nije se razlikovao od onih navedenih u literaturi.
English: About 2% of dexrazoxane is protein-bound.
Croatian: Oko 2% deksrazoksana veže se na proteine.
English: • Reduction in the number of white blood cells and platelets
Croatian: • Smanjenje broja bijelih krvnih stanica i trombocita
English: • Muscle pain, tremor (uncontrolled muscle movement)
Croatian: • Bol u mišićima, tremor (nekontrolirani pokreti mišića)
English: PREPARATION FOR THE INTRAVENOUS ADMINISTRATION
Croatian: PRIPREMANJE ZA INTRAVENSKU PRIMJENU
English: ADR-925 is reported to increase three-fold within 15 min after infusion of 1500 mg/m2 and remain relatively constant on a plateau for 4 hours and then decreased to about half at 24 hours.
Croatian: Zabilježeno je da se ADR-925 povećava trostruko unutar 15 minuta nakon infuzije od 1500 mg/m2 i 4 sata ostaje relativno nepromijenjen na platou te se zatim u 24 sata smanji na pola.
English: Dexrazoxane is not recommended in combination with phenytoin.
Croatian: Deksrazoksan se ne preporučuje u kombinaciji s fenitoinom.
English: Pharmacotherapeutic group: Detoxifying agents for antineoplastic agents, ATC code: V03AF02
Croatian: Farmakoterapijska skupina: detoksikacijske tvari za antineoplastične tvari, ATK oznaka: V03AF02
English: It is not known to what extent each of these mechanisms contributes to the preventive effect on tissue destruction following anthracycline extravasation.
Croatian: Nije poznato u kolikoj mjeri svaki od ova dva mehanizma doprinosi preventivnom učinku na uništavanje tkiva nakon ekstravazacije antraciklina.
English: Potassium 98 mg/500 ml or 5.0 mmol/l Sodium 1.61 g/500 ml or 140 mmol/l
Croatian: Kalij 98 mg/500 ml ili 5,0 mmol/l Natrij 1,61 g/500 ml ili 140 mmol/l
English: NN: {number} [national reimbursement number or other national number identifying the medicinal product]>
Croatian: SN: {broj} [serijalizacijski broj] NN: {broj} [nacionalni broj s liste lijekova ili drugi nacionalni broj za identifikaciju lijeka]
English: A requirement for inclusion in the efficacy part of the study was that the anthracycline extravasation was proven by fluorescence microscopy of one or more biopsies.
Croatian: Uvjet za uključenje u dio ispitivanja djelotvornosti bio je taj da je ekstravazacija antraciklina bila dokazana fluorescentnom mikroskopijom na jednoj ili više biopsija.
English: Other medicines and Savene Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.
Croatian: Obavijestite svog liječnika ili medicinsku sestru ako uzimate ili ste nedavno uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: In particular, tell your doctor or nurse if you are taking or may take any of the following medicines: - Vaccines: you must not use Savene if you are going to receive yellow fever vaccine and it is not recommended that you use Savene if you are going to receive a vaccine containing live virus particles.
Croatian: Osobito recite svom liječniku ili medicinskoj sestri ako uzimate ili biste mogli uzeti bilo koji od sljedećih lijekova: - Cjepiva: ne smijete koristiti Savene ako ćete primiti cjepivo protiv žute groznice i ne preporučuje se koristiti Savene ako ćete primiti cjepivo koje sadrži žive virusne čestice.
English: Dexrazoxane undergoes intracellular hydrolysis first to its two one-ring open intermediates (B and C) and then to the two-ring opened form (ADR-925) which has a structure similar to EDTA and is a strong chelator of iron and divalent cations as calcium ions.
Croatian: Deksrazoksan najprije prolazi unutarstaničnu hidrolizu do svoja dva jednoprstenasta otvorena intermedijarna spoja (B i C) te potom do otvorenog dvoprstenastog oblika (ADR-925) čija je struktura slična EDTA-i te je snažni kelator željeza i dvovalentnih kationa kao što su ioni kalcija.
English: Postoperative infection
Croatian: Postoperativna infekcija
English: AUCs were dose-proportional.
Croatian: Površine ispod krivulje (AUC) bile su proporcionalne dozi.
English: - Anticoagulants (blood thinners) (your blood may need to be monitored more frequently).
Croatian: - Antikoagulanse (lijekove koji razrjeđuju krv) (možda ćete morati češće obavljati pretrage krvi).
English: Two pharmacodynamic properties of dexrazoxane are described in the literature: Prevention of anthracycline cardiotoxicity, and Antineoplastic action
Croatian: Dva farmakodinamička svojstva deksrazoksana su opisana u literaturi: prevencija kardiotoksičnosti antraciklina i antineoplastično djelovanje
English: When tested in five major cytochrome P450 isoenzymes CYP1A, CYP2C9, CYP2C19, CYP2D6 and CYP3A4, none of these were inhibited by dexrazoxane.
Croatian: Kad je testiran uz pet glavnih izoenzima citokroma P450: CYP1A, CYP2C9, CYP2C19, CYP2D6 i CYP3A4, deksrazoksan nije inhibirao nijednog od njih.
English: The indicated dose should be administered as an intravenous infusion over 1-2 hours into a large vein of an extremity or area other than the one affected by the extravasation.
Croatian: Naznačena doza mora biti primijenjena kao intravenska infuzija tijekom 1-2 sata u veliku venu jednog od udova ili nekog drugog područja izuzev područja zahvaćenog ekstravazacijom.
English: Haematological monitoring should therefore be undertaken regularly.
Croatian: Zbog toga treba redovito kontrolirati hematološke parametre.
English: Dexrazoxane displays biphasic elimination kinetics.
Croatian: Deksrazoksan pokazuje bifazičnu kinetiku eliminacije.