FrancophonIA/ELRC3.0 huggingface dataset:
English: - All materials that may have come in contact with Luxturna (e.g. vial, syringe, needle, cotton gauze, gloves, masks or dressings) must be disposed of in accordance with local biosafety guidelines.
Croatian: • Svi materijali koji su mogli doći u kontakt s Luxturnom (npr. bočica, štrcaljka, igla, pamučna gaza, rukavice, maske ili zavoji) moraju se odložiti u skladu s lokalnim smjernicama za biosigurnost.
English: Mutations in the RPE65 gene lead to reduced or absent RPE65 all-trans-retinyl isomerase activity, blocking the visual cycle and resulting in vision loss.
Croatian: Mutacije u RPE65 genu dovode do smanjene ili odsutne aktivnosti RPE65 sav-trans-retinil izomeraze, što blokira vidni ciklus i dovodi do gubitka vida.
English: • You and your caregiver, especially if pregnant, breast-feeding or with a suppressed immune system, should wear gloves during dressing changes and when disposing of the dressings and other waste material.
Croatian: • Vi i Vaš(a) njegovatelj(ica), osobito u slučaju trudnoće, dojenja ili potisnutog imunološkog sustava, trebate nositi rukavice kod mijenjanja zavoja te odlaganja zavoja i drugih otpadnih materijala.
English: If you are given more Luxturna than you should be As this medicine is given to you by a doctor, it is unlikely that you will be given too much.
Croatian: Budući da Vam ovaj lijek daje liječnik, malo je vjerojatno da ćete dobiti previše.
English: Figure 2 shows the effect of the medicinal product over the three-year period in the voretigene neparvovec treatment group, as well as the effect in the control group after crossing over to receive subretinal injection of voretigene neparvovec.
Croatian: Slika 2 prikazuje učinak lijeka tijekom trogodišnjeg razdoblja u terapijskoj skupini koja je primila voretigen neparvovek, kao i učinak u kontrolnoj skupini nakon prijelaza na primanje subretinalne injekcije voretigen neparvoveka.
English: Luxturna will be given to you in an operating room by surgeons experienced in performing eye surgery.
Croatian: Luxturnu će u operacijskoj sali primijeniti kirurg iskusan u izvođenju operacija oka.
English: For storage conditions after thawing and dilution of the medicinal product, see section 6.3.
Croatian: Uvjete čuvanja nakon odmrzavanja i razrjeđivanja lijeka vidjeti u dijelu 6.3.
English: After thawing and dilution
Croatian: Nakon odmrzavanja i razrjeđivanja
English: The retinal pigment epithelium-specific 65 kilodalton protein (RPE65) is located in the retinal pigment epithelial cells and converts all-trans-retinol to 11-cis-retinol, which subsequently forms the chromophore, 11-cis-retinal, during the visual (retinoid) cycle.
Croatian: Protein od 65 kilodaltona specifičan za retinalni pigmentni epitel (RPE65) nalazi se u stanicama retinalnog pigmentnog epitela i pretvara sav-trans-retinol u 11-cis-retinol, koji zatim tijekom vidnog (retinoidnog) ciklusa stvara kromofor, 11-cis-retinal.
English: Figure 1A Subretinal injection cannula introduced via pars plana
Croatian: Slika 1A Kanila za subretinalnu injekciju uvedena kroz pars plana
English: • Retinal disorder (foveal thinning, loss of foveal function), macular hole, maculopathy (epiretinal membrane, macular pucker) and eye disorder (foveal dehiscence).
Croatian: • Poremećaj mrežnice (stanjenje fovee, gubitak funkcije fovee), rupa u makuli, makulopatija (epiretinalna membrana, makularno nabiranje) i poremećaj oka (fovealna dehiscencija).
English: vg voretigene neparvovec in a total volume of 300 μL.
Croatian: vg voretigen neparvoveka u ukupnom volumenu od 300 μl.
English: The concentrate (0.5 mL extractable volume in a single-dose 2 mL vial) requires a 1:10 dilution prior to administration.
Croatian: Koncentrat (0,5 ml raspoloživog volumena u jednodoznoj bočici od 2 ml) se mora razrijediti u omjeru 1:10 prije primjene.
English: • Supine head positioning is initiated immediately in the post-operative period and, upon discharge, patients should be advised to rest in a supine position as much as possible for 24 hours.
Croatian: • Glava se odmah postavlja vodoravno okrenuta prema gore u postoperativnom razdoblju, a nakon otpusta bolesnike treba uputiti da 24 sata miruju koliko god je moguće u tom istom položaju.
English: Difference (95% CI) (Intervention-Control) -2.33 (-3.44, -1.22), p<0.001
Croatian: N Srednja vrijednost (SE) -1,65 (0,14) Razlika (95% CI) (intervencijska-kontrolna) -2,33 (-3,44; -1,22), p<0,001
English: No pharmacokinetic studies with voretigene neparvovec have been conducted in special populations.
Croatian: Nisu provedena farmakokinetička ispitivanja s voretigen neparvovekom u posebnim populacijama.
English: After injection, any unused product must be discarded.
Croatian: Nakon injekcije, neiskorišteni lijek mora se odbaciti.
English: The safety and efficacy of voretigene neparvovec in patients ≥65 years old have not been established.
Croatian: Sigurnost i djelotvornost voretigen neparvoveka u bolesnika u dobi od ≥ 65 godina nisu ustanovljene.
English: SPKRPE-EUPASS: Non-interventional PASS: In order to further characterise the safety including long-term safety of Luxturna, the applicant should conduct and submit a study based on data from a disease registry in patients vision loss due to inherited retinal dystrophy caused by confirmed biallelic RPE65 mutations.
Croatian: Neintervencijski PASS: Kako bi se dodatno okarakterizirala sigurnost, uključujući dugotrajnu sigurnost primjene Luxturne, podnositelj zahtjeva treba provesti i predati ispitivanje temeljeno na podacima iz registra bolesti u bolesnika koji gube vid uslijed naslijeđene retinalne distrofije uzrokovane potvrđenim bialelnim RPE65 mutacijama.
English: System organ class / Frequency
Croatian: Klasifikacija organskih sustava / učestalost
English: The primary endpoint of the Phase 3 study measured the mean change from baseline to one year in binocular multi-luminance mobility testing (MLMT) between the intervention and control groups.
Croatian: Mjera primarnog ishoda ispitivanja faze 3 mjerila je srednju vrijednost promjene od početne vrijednosti do jedne godine u binokularnom testu mobilnosti uz različita osvjetljenja (engl. binocular multi-luminance mobility testing, MLMT) između skupine koja je dobivala lijek i kontrolne skupine.
English: The recommended site of injection is located along the superior vascular arcade, at least 2 mm distal to the centre of the fovea.
Croatian: Preporučeno mjesto primjene injekcije treba biti smješteno uz gornju vaskularnu arkadu, najmanje 2 mm distalno od središta fovee.
English: 21 subjects were randomised to receive subretinal injection of voretigene neparvovec.
Croatian: 21 ispitanik bio je randomiziran na primanje subretinalne injekcije voretigen neparvoveka.
English: Post-operative
Croatian: Poslije operacije
English: The corticosteroids may decrease the potential immune reaction to either vector capsid (adeno-associated virus serotype 2 [AAV2] vector) or transgene product (retinal pigment epithelial 65 kDa protein [RPE65]).
Croatian: Kortikosteroidi mogu smanjiti moguću imunološku reakciju ili na kapsidu vektora (vektor adeno-vezanog virusnog serotipa 2 [AAV2]) ili na produkt transgena (protein retinalnog pigmentnog epitela mase 65 kDa [RPE65]).
English: Patients should avoid swimming because of an increased risk of infection in the eye.
Croatian: Bolesnici trebaju izbjegavati plivanje zbog povećanog rizika of infekcije u oku.
English: Local biosafety guidelines for preparation, administration and handling of Luxturna should be followed.
Croatian: Potrebno je slijediti lokalne smjernice za biosigurnost kod pripreme, primjene i rukovanja Luxturnom.
English: Treatment should be initiated and administered by a retinal surgeon experienced in performing macular surgery.
Croatian: Liječenje mora započeti i primjenjivati retinalni kirurg s iskustvom u izvođenju operacija makule.
English: Prednisone (or equivalent) 1 mg/kg/day (maximum of 40 mg/day)
Croatian: Prednizon (ili ekvivalent) 1 mg/kg/dan (najviše 40 mg/dan)
English: Clinical pharmacokinetics and shedding
Croatian: Klinička farmakokinetika i izlučivanje
English: The solid line connects the mean MLMT score changes over visits for the treatment group.
Croatian: Puna linija povezuje srednje vrijednosti promjene rezultata za MLMT tijekom posjeta za terapijsku skupinu.
English: Do not prepare syringes for injection if the vials show any damage or if any visual particulates are observed.
Croatian: Ne pripremajte štrcaljke za injekciju ako bočice imaju bilo kakve znakove oštećenja ili ako uočite bilo kakve vidljive čestice.
English: Visual acuity (LogMAR) of the first eye of these subjects at baseline was 1.18 (0.14), mean (SE).
Croatian: Vidna oštrina (LogMAR) prvog oka tih ispitanika na početku bila je 1,18 (0,14), srednja vrijednost (SE).
English: A small amount of the product is slowly injected until an initial subretinal bleb is observed, and then, the remaining volume is slowly injected until the total 0.3 mL is delivered (Figure 1).
Croatian: Mala količina lijeka polako se injicira dok se ne vidi inicijalni subretinalni mjehurić, a zatim se preostali volumen polako injicira dok se ne injicira svih 0,3 ml (Slika 1).
English: XBL; XD30; XD90; XD180: baseline, 30, 90 and 180 days after start of study for control crossover group; XY1; XY2: one and two years after start of study for control crossover group.
Croatian: XBL; XD30; XD90; XD180: početak praćenja, 30, 90 i 180 dana nakon početka ispitivanja za kontrolnu skupinu koja je prešla na voretigen neparvovek;
English: • Headache, dizziness
Croatian: • Glavobolja, omaglica
English: These handling precautions should be followed for 14 days after administration of voretigene neparvovec.
Croatian: Te je mjere opreza kod rukovanja potrebno slijediti tijekom 14 dana nakon primjene voretigen neparvoveka.
English: Patients should avoid strenuous physical activity because of an increased risk of injury to the eye.
Croatian: Bolesnici trebaju izbjegavati naporne fizičke aktivnosti zbog povećanog rizika od ozljede oka.
English: Each single-dose 2 mL vial of Luxturna contains 0.5 extractable mL of concentrate which requires a 1:10 dilution prior to administration, see section 6.6.
Croatian: Jedna jednodozna bočica od 2 ml Luxturne sadrži 0,5 raspoloživih ml koncentrata koji je potrebno razrijediti u omjeru 1:10 prije primjene, vidjeti dio 6.6.
English: • After vitrectomy is completed, Luxturna is administered by subretinal injection using a subretinal injection cannula introduced via pars plana (Figure 1A).
Croatian: • Nakon što se obavi vitrektomija, Luxturna se primjenjuje subretinalnom injekcijom pomoću kanile za subretinalnu injekciju koja se uvodi kroz pars plana (Slika 1A).
English: Do not prepare syringe if the vial shows any damage or if any visual particulates are observed.
Croatian: Ne pripremajte štrcaljku ako bočice imaju bilo kakve znakove oštećenja ili ako uočite bilo kakve vidljive čestice.
English: The administration of voretigene neparvovec should be carried out in the surgical suite under controlled aseptic conditions.
Croatian: Voretigen neparvovek mora se primijeniti u operacijskoj sali u kontroliranim aseptičnim uvjetima.
English: • At the completion of the injection, the subretinal injection cannula is removed from the eye.
Croatian: • Po dovršetku injekcije, kanila za subretinalnu injekciju uklanja se iz oka.
English: However, after crossing-over to receive subretinal injection of voretigene neparvovec, the subjects in the control group showed a similar response to the voretigene neparvovec as compared to the subjects in the voretigene neparvovec treatment group.
Croatian: Međutim, nakon prijelaza na primanje subretinalne injekcije voretigen neparvoveka, ispitanici u kontrolnoj skupini imali su sličan odgovor na voretigen neparvovek u usporedbi s ispitanicima u terapijskoj skupini koja je primila voretigen neparvovek.
English: The following adverse reactions have been observed with the administration procedure:
Croatian: Sljedeće su nuspojave opažene uz postupak primjene:
English: • Breakdown of the surgical wound
Croatian: • Rascjep kirurške rane
English: Based on non-clinical studies and clinical data from trials of AAV2 vectors, and considering the subretinal route of administration of Luxturna, inadvertent germ-line transmission with AAV vectors is highly unlikely.
Croatian: Na temelju pretkliničkih ispitivanja i kliničkih podataka iz ispitivanja vektora AAV2 te uzimajući u obzir subretinalni način primjene Luxturne, vrlo je malo vjerojatna nehotična transmisija vektora AAV-a u genetski materijal gameta.
English: Solvent for Luxturna
Croatian: Otapalo za Luxturnu
English: Low levels of vector DNA sequences were detected in the optic nerve of the vector-injected eye, optic chiasm, spleen and liver, and sporadically in the stomach and lymph nodes.
Croatian: Niske razine sekvenci vektorske DNK bile su uočene u optičkom živcu oka u koje je bio injiciran vektor, optičkoj hijazmi (križanje vidnog živca), slezeni i jetri, te sporadično u želucu i limfnim čvorovima.
English: Table 3 Adverse reactions related to administration procedure
Croatian: Tablica 3 Nuspojave povezane s postupkom primjene
English: • Connect the syringe containing the diluted product to the tubing and microcannula.
Croatian: • Spojite štrcaljku koja sadrži razrijeđeni lijek na cjevčicu i mikrokanilu.
English: • After vitrectomy is completed, Luxturna is administered by subretinal injection using a commercially available subretinal injection cannula introduced via pars plana.
Croatian: • Nakon što se obavi vitrektomija, Luxturna se primjenjuje subretinalnom injekcijom pomoću komercijalno dostupne kanile za subretinalnu injekciju koja se uvodi putem pars plana.
English: vg (5 times the recommended per eye dose), vector DNA sequences were detected in colon, duodenum and trachea.
Croatian: vg (5 puta više od preporučene doze po oku), sekvence vektorske DNK bile su otkrivene u debelom crijevu, dvanaesniku i dušniku.
English: Thaw one single-dose vial of concentrate and two vials of solvent at room temperature.
Croatian: Odmrznite jednu jednodoznu bočicu koncentrata i dvije bočice otapala na sobnoj temperaturi.
English: Patients will receive a single dose of 1.5 x 10
Croatian: Bolesnici će primiti jednokratnu dozu od 1,5 x 10
English: The solvent is a clear, colourless liquid supplied in a clear plastic vial.
Croatian: Otapalo je bistra, bezbojna tekućina koja se isporučuje u prozirnoj plastičnoj bočici.
English: The most common adverse reactions (incidence ≥5%) related to the administration procedure were conjunctival hyperaemia, cataract, increased intraocular pressure, retinal tear, dellen, macular hole, subretinal deposits, eye inflammation, eye irritation, eye pain and maculopathy (wrinkling on the surface of the macula).
Croatian: Najčešće nuspojave (incidencija ≥ 5%) povezane s postupkom primjene bile su hiperemija konjunktive, katarakta, povišeni intraokularni tlak, ruptura mrežnice, ulegnuća na rubu rožnice, rupa u makuli, subretinalni depoziti, upala oka, nadražaj oka, bol u oku i makulopatija (nabiranje na površini makule).
English: Patients/caregivers should be advised to handle waste material generated from dressings, tears and nasal secretion appropriately, which may include storage of waste material in sealed bags prior to disposal.
Croatian: Bolesnike/njegovatelje potrebno je uputiti da na odgovarajući način postupaju s otpadnim materijalom nastalim od zavoja, suza i izlučevina iz nosa, što može uključivati spremanje otpadnog materijala u zapečaćene vrećice prije odlaganja.
English: The safety and efficacy of voretigene neparvovec in children aged up to 4 years have not been established.
Croatian: Sigurnost i djelotvornost voretigen neparvoveka u djece u dobi do 4 godine nisu još ustanovljene.
English: After dilution each dose of Luxturna contains 1.5 x 10
Croatian: Nakon razrjeđivanja, jedna doza Luxturne sadrži 1,5 x 10
English: Table 2 Adverse reactions related to voretigene neparvovec
Croatian: Tablica 2 Nuspojave povezane s voretigen neparvovekom
English: Luxturna is a sterile concentrate solution for subretinal injection that requires thawing and dilution prior to administration (see section 6.6).
Croatian: Luxturna je sterilni koncentrat otopine za subretinalnu injekciju koji se mora odmrznuti i razrijediti prije primjene (vidjeti dio 6.6).
English: Injection of voretigene neparvovec into the subretinal space results in transduction of retinal pigment epithelial cells with a cDNA encoding normal human RPE65 protein (gene augmentation therapy), providing the potential to restore the visual cycle.
Croatian: Injekcija voretigen neparvoveka u subretinalni prostor rezultira transdukcijom stanica retinalnog pigmentnog epitela s cDNK koja kodira normalni humani RPE65 protein (terapija augmentacije gena), što stvara mogućnost obnove vidnog ciklusa.
English: Concentrate and solvent must be stored and transported frozen at ≤-65 ºC.
Croatian: Koncentrat i otapalo moraju se čuvati i prevoziti zamrznuti na ≤ -65 ºC.
English: Subretinal use after dilution.
Croatian: Subretinalna primjena nakon razrjeđivanja.
English: Other findings from voretigene neparvovec non-clinical studies included occasional and isolated inflammatory cells in the retina, with no apparent retinal degeneration.
Croatian: Drugi nalazi iz nekliničkih ispitivanja voretigen neparvoveka uključivali su povremene i izolirane upalne stanice u mrežnici, bez vidljive degeneracije mrežnice.
English: A small amount of the product is slowly injected until an initial subretinal bleb is observed, and then the remaining volume is slowly injected until the total 0.3 mL is delivered.
Croatian: Mala količina lijeka polako se injicira dok se ne vidi inicijalni subretinalni mjehurić, a zatim se preostali volumen polako injicira dok se ne injicira svih 0,3 ml.
English: • You should avoid strenuous physical activity because of an increased risk of injury to the eye.
Croatian: • Izbjegavajte napornu fizičku aktivnost zbog povećanog rizika od ozljede oka.
English: Single-dose vial, 0.5 mL extractable volume
Croatian: Jednodozna bočica, 0,5 ml raspoloživog volumena
English: vg in a deliverable volume of 0.3 mL.
Croatian: vg u isporučivom volumenu od 0,3 ml.
English: Each single dose of 1.5 x 10
Croatian: Jedna jednokratna doza od 1,5 x 10
English: Therefore, no adjustment in dosage is necessary for patients with hepatic or renal impairment.
Croatian: Stoga nije potrebna prilagodba doze za bolesnike s oštećenjem funkcije jetre ili bubrega.
English: Symptomatic and supportive treatment, as deemed necessary by the treating physician, is advised in case of overdose.
Croatian: U slučaju predoziranja savjetuje se simptomatsko i suportivno liječenje, prema prosudbi liječnika koji provodi liječenje.
English: 1 vial concentrate 2 vials solvent
Croatian: 1 bočica koncentrata 2 bočice otapala
English: There is no clinical experience with overdose of voretigene neparvovec.
Croatian: Nema kliničkog iskustva s predoziranjem voretigen neparvovekom.
English: The highest levels of vector DNA sequences were detected in intraocular fluids (anterior chamber fluid and vitreous) of vector-injected eyes.
Croatian: Najviše razine sekvenci vektorske DNK bile su uočene u intraokularnim tekućinama (tekućina prednje očne komore i staklovina) očiju u koje je bio injiciran vektor.
English: The pupil of the eye to be injected must be dilated, and a broad-spectrum microbiocide should be topically administered prior to the surgery according to standard medical practice.
Croatian: Potrebno je raširiti zjenicu oka u koje će se primijeniti injekcija te topikalno primijeniti mikrobicid širokog spektra prije zahvata sukladno standardnoj medicinskoj praksi.
English: Visual acuity (LogMAR) of the first eye of these subjects at baseline was 1.29 (0.21), mean (SE).
Croatian: Vidna oštrina (LogMAR) prvog oka tih ispitanika na početku bila je 1,29 (0,21), srednja vrijednost (SE).
English: Luxturna is a single-use vial for a single administration in one eye only.
Croatian: Luxturna je bočica za jednokratnu uporabu za jednokratnu primjenu samo u jedno oko.
English: Once thawed, the medicine should not be re-frozen and should be left at room temperature (below 25 °C).
Croatian: Nakon što se odmrzne, lijek se ne smije ponovo zamrzavati i treba se ostaviti na sobnoj temperaturi (ispod 25 °C).
English: The active substance in Luxturna, voretigene neparvovec, is a modified virus that contains a working copy of the RPE65 gene.
Croatian: Djelatna tvar u Luxturni, voretigen neparvovek, modificirani je virus koji sadrži ispravnu kopiju RPE65 gena.
English: Luxturna is a gene therapy product that contains the active substance voretigene neparvovec.
Croatian: Luxturna je lijek za gensku terapiju koji sadrži djelatnu tvar voretigen neparvovek.
English: AAV2-hRPE65v2-LTFU-01: In order to further evaluate the long-term efficacy and safety outcomes of Luxturna in adult and paediatric patients with vision loss due to inherited retinal dystrophy caused by confirmed biallelic RPE65 mutations, the applicant should submit the long-term efficacy and safety follow-up of trial participants who received Luxturna in the clinical programme (15-year follow-up).
Croatian: Da bi se dodatno procijenilo dugoročne ishode djelotvornosti i sigurnosti Luxturne u odraslih i pedijatrijskih bolesnika s gubitkom vida uslijed naslijeđene retinalne distrofije uzrokovane potvrđenim bialelnim RPE65 mutacijama, podnositelj zahtjeva treba podnijeti rezultate dugoročnog praćenja (follow-up) djelotvornosti i sigurnosti u ispitanika koji su primili Luxturnu u kliničkom programu (15-godišnje praćenje).
English: Prednisone (or equivalent) 0.5 mg/kg every other day (maximum of 20 mg/day)
Croatian: Prednizon (ili ekvivalent) 0,5 mg/kg svaki drugi dan (najviše 20 mg/dan)
English: Active intraocular inflammation.
Croatian: Aktivna intraokularna upala.
English: vg will be delivered into the subretinal space in a total volume of 0.3 mL per eye.
Croatian: vg primijenit će se u subretinalni prostor u ukupnom volumenu od 0,3 ml po oku.
English: Each foil pouch includes a carton containing 1 vial of concentrate and 2 vials of solvent.
Croatian: Svaka vrećica od folije uključuje kutiju koja sadrži 1 bočicu koncentrata i 2 bočice otapala.
English: The safety and efficacy of voretigene neparvovec have not been established in patients with hepatic or renal impairment.
Croatian: Sigurnost i djelotvornost voretigen neparvoveka nisu ustanovljene u bolesnika s oštećenjem funkcije jetre ili bubrega.
English: XY2
Croatian: XG2
English: The dot within each box represents the mean.
Croatian: Točka unutar svakog pravokutnika predstavlja srednju vrijednost.
English: Voretigene neparvovec is a gene transfer vector that employs an adeno-associated viral vector serotype 2 (AAV2) capsid as a delivery vehicle for the human retinal pigment epithelium 65 kDa protein (hRPE65) cDNA to the retina.
Croatian: Voretigen neparvovek je vektor za transfer gena koji koristi kapsidu adeno-vezanog virusnog vektora serotipa 2 (AAV2) kao sredstvo dostave cDNK proteina humanog retinalnog pigmentnog epitela mase 65 kDa (hRPE65) u mrežnicu.
English: • All materials that may have come in contact with voretigene neparvovec (e.g. vial, syringe, needle, cotton gauze, gloves, masks or dressings) must be disposed of in accordance with local biosafety guidelines.
Croatian: • Svi materijali koji su mogli doći u kontakt s voretigen neparvovekom (npr. bočica, štrcaljka, igla, pamučna gaza, rukavice, maske ili zavoji) moraju se odložiti u skladu s lokalnim smjernicama za biološki opasne materijale.
English: Difference (95% CI) (Intervention-Control) -1.89 (-3.03, -0.75), p=0.002 Full-field light sensitivity testing - Averaged across both eyes (ITT) Difference (95% CI) (Intervention-Control): -2.11 (-3.19, -1.04), p<0.001
Croatian: Testiranje fotoosjetljivosti u punom vidnom polju-prosječno za oba oka (ITT) Razlika (95% CI) (intervencijska-kontrolna): -2,11 (-3,19; -1,04), p<0,001
English: • All spills of voretigene neparvovec must be treated with a virucidal agent such as 1% sodium hypochlorite and blot using absorbent materials.
Croatian: • Mogući proliveni voretigen neparvovek mora se tretirati virucidnim sredstvom kao što je 1%-tni natrijev hipoklorit i upiti upijajućim materijalom.