FrancophonIA/ELRC3.0 huggingface dataset:
English: Take two 400 milligram tablets at the same time or one 800 miligram tablet, once a day, every day.
Slovenian: Navodila za odrasle - Vsak dan (enkrat na dan) vzemite dve400mg tableti istočasno ali eno 800mg tableto.
English: If antidepressants are co-administered with darunavir with low dose ritonavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Slovenian: Pri sočasni uporabi antidepresivov in darunavirja skupaj z majhnim odmerkom ritonavirja se priporoča titracija odmerka antidepresiva na podlagi klinične ocene učinka antidepresiva.
English: The metabolism of alfentanil is mediated via CYP3A, and may as such be inhibited by darunavir co-administered with low dose ritonavir.
Slovenian: Presnova alfentanila poteka preko CYP3A in jo lahko zavira darunavir skupaj z majhnim odmerkom ritonavirja.
English: Darunavir Krka 800 mg film-coated tablets (tablets):
Slovenian: Darunavir Krka 800 mg filmsko obložene tablete (tablete):
English: Imputations according to the TLOVR algorithm d Based on normal approximation to the difference in % response Non-completer is failure imputation: patients who discontinued prematurely are imputed with a change equal to 0
Slovenian: podatki na osnovi analiz po 48. tednu podatki na osnovi analiz po 96. tednu pripisane vrednosti, izračunane z uporabo algoritma TLOVR na osnovi normalne aproksimacije razlike v % odziva bolniki, ki niso dokončali preskušanja, so označeni kot neuspešni: bolnikom, ki so predčasno prenehali sodelovati v preskušanju, so pripisali vrednost spremembe 0
English: Efficacy of darunavir 800 mg once daily co-administered with 100 mg ritonavir once daily in ARTexperienced patients
Slovenian: Učinkovitost 800 mg darunavirja enkrat na dan s 100 mg ritonavirja enkrat na dan pri bolnikih, ki imajo izkušnje z ART
English: The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing this disease.
Slovenian: Pri dolgotrajnem zdravljenju HIV, hujši prizadetosti imunskega sistema, preveliki telesni masi, uživanju alkohola ali kortikosteroidov je verjetnost za pojav osteonekroze večja.
English: Given that digoxin has a narrow therapeutic index, it is recommended that the lowest possible dose of digoxin should initially be prescribed in case digoxin is given to patients on boosted darunavir therapy.
Slovenian: Zaradi majhne terapevtske širine digoksina se priporoča, da bolniki, ki sočasno prejemajo zdravili darunavir/ritonavir, na začetku prejemajo najnižji možni odmerek digoksina.
English: Life-threatening and fatal drug interactions have been reported in patients treated with colchicine and strong inhibitors of CYP3A and P-glycoprotein (P-gp; see sections 4.3 and 4.5).
Slovenian: Pri bolnikih, ki so se zdravili s kolhicinom in močnimi zaviralci CYP3A in Pglikoproteina (P-gp; glejte poglavji 4.3 in 4.5) so poročali o življenjsko nevarnih medsebojnih delovanjih zdravil ter smrtnih primerih.
English: Plasma concentrations of these medicinal products may be increased when co-administered with boosted darunavir, resulting in reduced serum cortisol concentrations.
Slovenian: Ob sočasni uporabi z okrepljenim darunavirjem se lahko plazemske koncentracije teh zdravil zvišajo, serumske koncentracije kortizola pa znižajo.
English: Darunavir co-administered with low dose ritonavir must not be used concomitantly with products containing St John's wort (Hypericum perforatum) (see section 4.3).
Slovenian: Med jemanjem darunavirja skupaj z majhnim odmerkom ritonavirja se ne smejo uporabljati pripravki, ki vsebujejo šentjanževko (Hypericum perforatum) (glejte poglavje 4.3).
English: Combinations with optimised background regimen (OBRs) other than ≥ 2 NRTIs have not been studied in this population.
Slovenian: Pri tej populaciji so preučevali samo kombinacije z optimiziranim osnovnim režimom zdravljenja (OBROptimised Background Regimen) z ≥ 2 NRTI.
English: The recommended dose of emtricitabine/tenofovir alafenamide is 200/10 mg once daily when used with boosted darunavir.
Slovenian: Priporočeni odmerek emtricitabin/alafenamidtenofovirata v kombinaciji z okrepljenim zdravilom darunavir je 200/10 mg enkrat na dan abakavir emtricitabin lamivudin stavudin zidovudin
English: Co-administration of darunavir and ritonavir with other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir, which may result in increased plasma concentrations of darunavir and ritonavir.
Slovenian: Sočasna uporaba darunavirja in ritonavirja z drugimi zdravili, ki zavirajo CYP3A, lahko zmanjša očistek darunavirja in ritonavirja ter povzroči zvišanje njunih plazemskih koncentracij.
English: Response (HIV-1 RNA < 50 copies/ml at week 24) %, n/N
Slovenian: kopij/ml v 24. tednu) %, n/N
English: Hence, concomitant use of boosted darunavir and the combination product lopinavir/ritonavir is contraindicated (see section 4.3).
Slovenian: Zato je sočasna uporaba okrepljenega darunavirja in kombinacije zdravil lopinavir/ritonavir kontraindicirana (glejte poglavje 4.3).
English: Hepatobiliary disorders common hepatic enzyme increased uncommon hepatitis*, cytolytic hepatitis*
Slovenian: Občasni hepatitis*, citolitično hepatitis*
English: You will require a different dose of Darunavir Krka which cannot be administered with these 600 milligram tablets.
Slovenian: Potrebovali boste odmerek, ki se ga ne da doseči s tabletami po 600 mg. Na voljo so druge jakosti zdravila Darunavir Krka.
English: Darunavir Krka is available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a boxes.
Slovenian: Zdravilo Darunavir Krka je na voljo v plastenkah po 30 filmsko obloženih tablet (1 plastenka po 30 filmsko obloženih tablet), 60 filmsko obloženih tablet (2 plastenki po 30 filmsko obloženih tablet), 90 filmsko obloženih tablet (3 plastenke po 30 filmsko obloženih tablet) in 180 filmsko obloženih tablet (6 plastenk po 30 filmsko obloženih tablet), v škatli.
English: dysfunction with darunavir coadministered with low dose ritonavir should be done with caution.
Slovenian: motenj erekcije) z darunavirjem z majhnim odmerkom ritonavirja je potrebna previdnost.
English: Concomitant use of colchicine and darunavir co-administered with low dose ritonavir may increase the exposure to colchicine.
Slovenian: Pri sočasni uporabi kolhicina in darunavirja skupaj z majhnim odmerkom ritonavirja se lahko zveča izpostavljenost kolhicinu.
English: When administered without food, the relative bioavailability of darunavir in the presence of cobicistat or low dose ritonavir is lower as compared to intake with food.
Slovenian: Pri jemanju darunavirja (v prisotnosti kobicistata ali ritonavirja v majhnem odmerku) brez hrane je njegova relativna biološka uporabnost manjša kot pri jemanju s hrano, zato je treba tablete darunavirja jemati s kobicistatom ali z ritonavirjem in s hrano.
English: Co-administration with herbal preparations containing St John's wort (Hypericum perforatum) (see section 4.5).
Slovenian: Sočasno jemanje z zdravili rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum) (glejte poglavje 4.5).
English: Darunavir Krka 400 and 800 milligram tablets are only to be used to construct the once daily 800 milligram regimen.
Slovenian: Tablete zdravila Darunavir Krka po 400 in 800 mg se lahko uporabljajo samo za režim odmerjanja 800 mg enkrat na dan.
English: The use of these medicines with darunavir/cobicistat is contraindicated (see section 4.3).
Slovenian: Uporaba teh učinkovin s kombinacijo darunavir/kobicistat je kontraindicirana (glejte poglavje 4.3).
English: Edoxaban
Slovenian: Nisopreučevali.
English: Concomitant administration of darunavir with low dose ritonavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity.
Slovenian: Sočasna uporaba darunavirja skupaj z majhnim odmerkom ritonavirja in s kvetiapinom je kontraindicirana, ker lahko zveča s kvetiapinom povezano toksičnost.
English: PHOSPHODIESTERASE, TYPE 5 (PDE-5) INHIBITORS
Slovenian: ZAVIRALCI FOSFODIESTRAZE TIPA 5 (PDE-5) Za zdravljenje motenj erekcije avanafil sildenafil tadalafil vardenafil
English: 6/l (see section
Slovenian: 6/l (glejte poglavje
English: Combination of rifampicin with darunavir with concomitant low dose ritonavir (see section 4.5).
Slovenian: Kombinacija rifampicina in darunavirja skupaj z majhnim odmerkom ritonavirja (glejte poglavje 4.5).
English: Co-administration of darunavir and ritonavir with medicinal products which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result in increased plasma concentrations of these medicinal products, which could increase or prolong their therapeutic effect and adverse reactions.
Slovenian: Sočasna uporaba darunavirja in ritonavirja z zdravili, ki se presnavljajo predvsem s CYP2D6 (flekainid, propafenon, metoprolol), lahko povzroči zvečanje plazemskih koncentracij teh zdravil, kar lahko zveča ali podaljša njihov terapevtski učinek in neželene učinke.
English: In clinical trials, rash was mostly mild to moderate, often occurring within the first four weeks of treatment and resolving with continued dosing.
Slovenian: Najpogosteje se je pojavljal v prvih štirih tednih zdravljenja in ob nadaljevanju zdravljenja izzvenel.
English: Third trimester of pregnancy (n=6)
Slovenian: Tretje trimesečje nosečnosti (n=6)
English: Monitoring of renal function may be indicated when boosted darunavir is given in combination with tenofovir disoproxil, particularly in patients with underlying systemic or renal disease, or in patients taking nephrotoxic agents.
Slovenian: Kadar se okrepljen darunavir uporablja v kombinaciji z dizoproksiltenofoviratom, še posebej pri bolnikih s sistemsko ali ledvično boleznijo ali pri bolnikih, ki jemljejo nefrotoksična zdravila, bo morda potrebno spremljanje ledvične funkcije.
English: In the table below the specific pharmacokinetic enhancer is specified when recommendations differ.
Slovenian: Če se priporočila razlikujejo, je v spodnji preglednici naveden farmakokinetični ojačevalec.
English: Boosted darunavir can be expected to increase the plasma concentrations of calcium channel
Slovenian: Pričakovati je, da okrepljen darunavir zviša plazemske koncentracije zaviralcev kalcijevih kanalčkov.
English: Appropriate laboratory testing should be conducted prior to initiating therapy with darunavir used in combination with cobicistat or low dose ritonavir and patients should be monitored during treatment.
Slovenian: Pred začetkom zdravljenja z darunavirjem v kombinaciji s kobicistatom ali z majhnim odmerkom ritonavirja je treba opraviti ustrezne laboratorijske teste in spremljati bolnika med zdravljenjem.
English: Exposure to these immunosuppressants will be increased when co-administered with darunavir coadministered with low dose ritonavir.
Slovenian: Pričakovano je zvečanje izpostavljenosti navedenim imunosupresivompri njihovi sočasni uporabi z darunavirjem skupaj z majhnim odmerkom ritonavirja.
English: Phenobarbital and phenytoin are expected to decrease plasma concentrations of darunavir and its pharmacoenhancer.
Slovenian: Zaradi indukcije encimov CYP450 s fenobarbitalom in fenitoinom je pričakovati znižanje koncentracij darunavirja in njegovih farmakokinetičnih ojačevalcev.
English: When administration of atorvastatin and darunavir co-administered with low dose ritonavir is desired, it is recommended to start with an atorvastatin dose of 10 mg once daily.
Slovenian: Če želite uporabljati atorvastatin in darunavir skupaj z majhnim odmerkom ritonavirja, je priporočljivo začeti z odmerkom atorvastatina 10 mg enkrat na dan. Glede na klinični odziv bolnika lahko odmerek atorvastatina postopoma zvečate.
English: Gastrointestinal disorders very common diarrhoea, nausea common vomiting, abdominal pain, abdominal distension, dyspepsia, flatulence, pancreatic enzymes increased uncommon pancreatitis acute
Slovenian: Bolezni prebavil zelo pogosti diareja, navzea pogosti bruhanje, bolečine v trebuhu, napihnjen trebuh, dispepsija, flatulenca, zvišane koncentracije encimov trebušne slinavke občasni akutni pankreatitis
English: These can include, but are not limited to, severe rash or rash accompanied by fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis and/or eosinophilia.
Slovenian: Znaki in simptomi hudih kožnih reakcij lahko med drugimi vključujejo hud izpuščaj ali izpuščaj in zvišanje telesne temperature, slabo počutje, utrujenost, bolečine v mišicah ali sklepih, mehurjaste izpuščaje, razjede v ustih, konjunktivitis, hepatitis in/ali eozinofilijo.
English: You must eat a meal or a snack within 30 minutes prior to taking your Darunavir Krka and ritonavir.
Slovenian: 30 minut preden vzamete zdravilo Darunavir Krka in ritonavir, morate pojesti obrok ali prigrizek.
English: Metabolism and nutrition disorders common diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia, hyperlipidaemia uncommon gout, anorexia, decreased appetite, decreased weight, increased weight, hyperglycaemia, insulin resistance, decreased high density lipoprotein, increased appetite, polydipsia, increased blood lactate dehydrogenase
Slovenian: Presnovne in prehranske motnje pogosti sladkorna bolezen, hipertrigliceridemija, hiperholesterolemija, hiperlipidemija občasni protin, anoreksija, zmanjšan tek, zmanjšana telesna masa, zvečana telesna masa, hiperglikemija, odpornost proti insulinu, znižana koncentracija lipoproteinov visoke gostote, zvečan tek, polidipsija, povišana koncentracija laktatdehidrogenaze v krvi
English: In the 96 week analysis, the safety profile of darunavir/ritonavir 800/100 mg once daily in treatmentnaïve subjects was similar to that seen with darunavir/ritonavir 600/100 mg twice daily in treatmentexperienced subjects except for nausea which was observed more frequently in treatment-naïve subjects.
Slovenian: Pri analizi podatkov po 96 tednih zdravljenja je bila varnost zdravil darunavir/ritonavir 800/100 mg enkrat na dan pri bolnikih, ki še niso bili zdravljeni s protiretrovirusnimi zdravili, podobna kot varnost zdravil darunavir/ ritonavir 600/100 mg dvakrat na dan pri bolnikih, ki so se že zdravili s protiretrovirusnimi zdravili.
English: Concominant use of everolimus or irinotecan and darunavir coadministered with low dose ritonavir is not recommended.
Slovenian: Sočasna uporaba everolimusa ali irinotekana in darunavirja skupaj z majhnim odmerkom ritonavirja ni priporočljiva.
English: Ethinylestradiol Norethindrone 35 μg/1 mg once daily drospirenone AUC ↑ 58% drospirenone Cmin ND drospirenone Cmax ↑ 15%
Slovenian: 35 µg/1 mg enkrat na dan drospirenon AUC ↑ 58% drospirenon Cmin ND drospirenon Cmax ↑ 15% etinilestradiol AUC  30% etinilestradiol Cmin ND etinilestradiol Cmax  14%
English: In women receiving darunavir/ritonavir 800/100 mg once daily during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC24h and Cmin were 33%, 31% and 30% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC24h and Cmin values were 29%, 32% and 50% lower, respectively, as compared with postpartum.
Slovenian: Pri ženskah, ki so med drugim trimesečjem nosečnosti prejemale zdravili darunavir/ritonavir v odmerkih 800/100 mg enkrat na dan, so bile med posameznicami povprečne vrednosti celokupnega darunavirja Cmax, AUC24h in Cmin za 33 %, 31 % oziroma 30 % manjše kot v obdobju po porodu.
English: Therapeutic drug monitoring of the immunosuppressive agent must be done when co-administration occurs.
Slovenian: Pri sočasni uporabi je treba spremljati terapevtske koncentracije imunosupresiva.
English: darunavir/ ritonavir darunavir/ ritonavir 800/100 mg darunavir/ ritonavir darunavir/ ritonavir 600/100 mg
Slovenian: TITAN 48. teden darunavir/ritona vir 800/100 mg darunavir/ritona vir 800/100 mg darunavir/ritona vir 600/100 mg darunavir/ritona vir 600/100 mg enkrat na dan n = 343
English: Concomitant use of salmeterol and darunavir co-administered with low dose ritonavir may increase plasma
Slovenian: Pri sočasni uporabi salmeterola in darunavirja v kombinaciji z majhnim odmerkom ritonavirja lahko pride do zvišanja
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with darunavir and low dose ritonavir is not recommended.
Slovenian: Sočasna uporaba tadalafila (za zdravljenje pljučne arterijske hipertenzije) z darunavirjem skupaj z majhnim odmerkom ritonavirja ni priporočljiva.
English: Do not stop taking Darunavir Krkawithout talking to your doctor first Anti-HIVmedicinesmaymake you feel better.
Slovenian: Ne prenehajte jemati zdravila Darunavir Krka, ne da bi se najprej posvetovali s svojim zdravnikom
English: Treatment difference darunavir / ritonavir 600/100 mg twice daily n=131
Slovenian: razlika v zdravljenju darunavir/ ritonavir 600/100 mg dvakrat na dan n = 131
English: HIV-1 RNA < 50 copies/ml median CD4+ cell count change from baseline (x 10
Slovenian: HIV-1 RNK < 50 kopij/ml Povprečna sprememba števila celic CD4+ glede na začetno vrednost (x 10
English: (CYP2D6 and/or CYP3A inhibition)
Slovenian: (zaviranje CYP2D6 in/ali CYP3A)
English: Monitoring of renal function may be indicated when darunavir coadministered with low dose ritonavir is given in combination with tenofovir disoproxil, particularly in patients with underlying systemic or renal disease, or in patients taking nephrotoxic agents.
Slovenian: Kadar se darunavir z majhnim odmerkom ritonavirja uporablja v kombinaciji z dizoproksiltenofoviratom, še posebej pri bolnikih s sistemsko ali ledvično boleznijo ali pri bolnikih, ki jemljejo nefrotoksična zdravila, bo morda potrebno spremljanje ledvične funkcije.
English: 800 mg darunavir/100 mg ritonavir once daily ritonavir oral solution: 80 mg/ml
Slovenian: 800 mg darunavirja/100 mg ritonavirja enkrat na dan peroralna raztopina ritonavirja: 80 mg/ml
English: Human experience of acute overdose with darunavir co-administered with low dose ritonavir is limited.
Slovenian: Izkušnje z akutnim prevelikim odmerjanjem darunavirja skupaj z majhnim odmerkom ritonavirja pri ljudeh so omejene.
English: Therefore, co-administration of darunavir with low dose ritonavir and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Slovenian: Zato je sočasna uporaba darunavirja skupaj z majhnim odmerkom ritonavirja in sildenafila za zdravljenje pljučne arterijske hipertenzije kontraindicirana (glejte poglavje 4.3).
English: Cmax, ng/ml AUC24h, ng.h/ml Cmin, ng/ml
Slovenian: AUC24h, ng.h/ml Cmin, ng/ml
English: The use of carbamazepine with darunavir co-administered with cobicistat is contraindicated (see section 4.3).
Slovenian: Uporaba karbamazepina s kombinacijo darunavir/kobicistat je kontraindicirana (glejte poglavje 4.3).
English: Atorvastatin 10 mg once daily atorvastatin AUC ↑ 3-4 fold atorvastatin Cmin ↑ ≈5.5-10 fold atorvastatin Cmax ↑ ≈2 fold darunavir/ritonavir atorvastatin AUC ↑ 290% atorvastatin Cmax ↑ 319% atorvastatin Cmin ND
Slovenian: Zato je sočasna uporaba okrepljenega darunavirja z lovastatinom ali s simvastatinom kontraindicirana (glejte poglavje atorvastatin 10 mg enkrat na dan atorvastatin AUC ↑ 3- do 4-krat atorvastatin Cmin ↑ ≈5,5- do 10-krat atorvastatin Cmax ↑ ≈2-krat darunavir/ritonavir atorvastatin AUC ↑ 290% atorvastatin Cmax ↑ 319% atorvastatin Cmin ND
English: Systemic corticosteroid effects including Cushing's syndrome and adrenal suppression have been reported in patients receiving ritonavir and inhaled or intranasally administered fluticasone.
Slovenian: Pri bolnikih, ki so prejemali ritonavir in inhalacijsko ali intranazalno dani flutikazon, so poročali o sistemskih učinkih kortikosteroidov, vključno s Cushingovim sindromom in supresijo nadledvične žleze.
English: General disorders and administration site conditions common asthenia, fatigue uncommon pyrexia, chest pain, peripheral oedema, malaise, feeling hot, irritability, pain rare chills, abnormal feeling, xerosis
Slovenian: Splošne težave in spremembe na mestu aplikacije pogosti astenija, izčrpanost občasni pireksija, bolečine v prsih, periferni edem, splošno slabo počutje, občutek vročine, razdražljivost, bolečina redki mrzlica, nenavadno počutje, kseroza
English: Metabolic parameters Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section
Slovenian: Presnovni parametri Med protiretrovirusnim zdravljenjem se lahko poveča telesna masa ter zviša koncentracija lipidov in glukoze v krvi (glejte poglavje 4.4).
English: Artemether/lumefantrine (a combination medicine to treat malaria) Dasatinib, everolimus,irinotecan,nilotinib, vinblastine, vincristine (to treat cancer) Sildenafil, tadalafil, vardenafil (for erectile dysfunction or to treat a heart and lung disorder called pulmonary arterial hypertension)
Slovenian: - buprenorfin/nalokson (zdravili za zdravljenje odvisnosti od opioidov) - salmeterol(zdravilo za zdravljenje astme) - artemeter/lumefantrin (kombinirano zdravilo za zdravljenje malarije) - dasatinib, everolimus, irinotekan, nilotinib, vinblastin, vinkristin (za zdravljenje raka) - sildenafil, tadalafil, vardenafil (za zdravljenjemotenj erekcije ali boleznisrca in pljuč, ki jo imenujemo pljučna arterijska hipertenzija) - glekaprevir/pibrentasvir,simeprevir (za zdravljenje okužbe z virusom hepatitisa C) - fentanil, oksikodon, tramadol(za zdravljenje bolečine) - fesoterodin, solifenacin (za zdravljenje bolezni sečil)
English: Darunavir dose is
Slovenian: En odmerek je
English: Darunavir co-administered with low dose ritonavir can be co-administered with H2-receptor antagonists without dose adjustments.
Slovenian: Darunavir skupaj z majhnim odmerkom ritonavirja lahko uporabljamo sočasno z antagonisti receptorjev H2, brez prilagajanja odmerka.
English: Adverse reactions observed with darunavir/cobicistat in adult patients
Slovenian: Neželeni učinki darunavirja/kobicistata opaženi pri odraslih bolnikih
English: The recommended dose of emtricitabine/tenofovir alafenamide is 200/10 mg once daily when used with darunavir with low dose ritonavir.
Slovenian: Priporočeni odmerek emtricitabin/alafenamidtenofovirata v kombinaciji z darunavirjem z majhnim odmerkom ritonavirja je 200/10 mg enkrat na dan.
English: Second trimester of pregnancy (n=17)
Slovenian: Drugo trimesečje nosečnosti (n = 17)
English: 600 mg darunavir /100 mg ritonavir twice daily with ritonavir oral solution: 80 mg/ml
Slovenian: 600 mg darunavirja/100 mg ritonavirja dvakrat na dan peroralna raztopina ritonavirja: 80 mg/ml
English: St John's wort is expected to decrease the plasma concentrations of darunavir and ritonavir.
Slovenian: Lahko pričakujemo znižanje plazemskih koncentracij darunavirja in ritonavirja.
English: Concomitant systemic use of clotrimazole and darunavir co-administered with low dose ritonavir may increase plasma concentrations of darunavir and/or clotrimazole.
Slovenian: Sočasna sistemska uporaba klotrimazola in darunavirja skupaj z majhnim odmerkom ritonavirja lahko zveča plazemske koncentracije darunavirja in/ali klotrimazola.
English: Second trimester of pregnancy (n=7)
Slovenian: Drugo trimesečje nosečnosti (n=7)
English: (CYP3A and/or CYP2D6 inhibition)
Slovenian: (zaviranje CYP3A in/ali CYP2D6)
English: The combination of avanafil and darunavir with low dose ritonavir is contraindicated (see section 4.3).
Slovenian: Kombinacija avanafila in darunavirja skupaj z majhnim odmerkom ritonavirja je kontraindicirana (glejte poglavje 4.3).
English: Therefore, coadministration of boosted darunavir and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Slovenian: Zato je sočasna uporaba okrepljenega darunavirja in sildenafila za zdravljenje pljučne arterijske hipertenzije kontraindicirana (glejte poglavje 4.3).