FrancophonIA/ELRC3.0 huggingface dataset:
English: The suggested dose titration of 25mg/day for one week with 25mg weekly increments was endorsed by the CHMP.
Slovenian: CHMP je potrdil priporočeno titracijo odmerkov 25 mg/dan za en teden, čemur sledijo tedenska povečanja odmerka po 25 mg.
English: Janssen-Cilag NV - BE Roderveldlaan 1 2600 Berchem, Belgium
Slovenian: Janssen-Cilag NV - BE Roderveldlaan 1 2600 Berchem, Belgija
English: APPEAR ON THE OUTER PACKAGING Carton for Plastic bottle
Slovenian: PODATKI NA ZUNANJI OVOJNINI Škatla za plastenko
English: • Increase in seizures
Slovenian: • povečano število napadov
English: Janssen-Cilag S.A. - ES
Slovenian: Janssen-Cilag S.A. - FR
English: • Be sure to swallow the entire spoonful of the sprinkle/food mixture immediately.
Slovenian: • Pazite, da boste takoj pogoltnili celotno žličko mešanice hrane z zdravilom.
English: The recommended monotherapy dosage of 100 - 200 mg/day as the initial target dose and the maximum daily dose of 500mg/day in monotherapy in adults, and the initial target dose of 100 mg/day depending on clinical response in children aged 6 years and above was endorsed by the CHMP for use.
Slovenian: CHMP je potrdil priporočeno odmerjanje 100-200 mg/dan kot začetni ciljni odmerek pri monoterapiji in 500 mg/dan kot največji dnevni odmerek v okviru monoterapije pri odraslih bolnikih ter 100 mg/dan kot začetni ciljni odmerek v odvisnosti od kliničnega odziva pri otrocih, starih 6 let ali več.
English: If you stop taking Topamax
Slovenian: Če ste prenehali jemati zdravilo Topamax
English: Effects on growth were also indicated by lower weights at birth and during lactation for pups from female rats treated with 20 or 100 mg/kg/day during gestation and lactation.
Slovenian: Z manjšimi masami ob kotitvi in med laktacijo so se pokazali tudi učinki na rast mladičev samic, ki so prejemale 20 ali 100 mg/kg/dan med brejostjo in laktacijo.
English: A drug-drug interaction study conducted in patients with type 2 diabetes evaluated the steady-state pharmacokinetics of glyburide (5 mg/day) alone and concomitantly with topiramate (150 mg/day).
Slovenian: V študiji medsebojnega delovanja zdravil, opravljeni pri bolnikih s sladkorno boleznijo tipa 2, so ovrednotili farmakokinetiko gliburida v stanju dinamičnega ravnovesja (v odmerku 5 mg/dan), kadar so ga uporabljali samostojno ali sočasno s topiramatom (v odmerku 150 mg/dan).
English: Hypotension, orthostatic hypotension flushing, hot flush,
Slovenian: Žilne bolezni hipotenzija, ortostatska hipotenzija, pordelost, navali vročine
English: Limited observations in patients suggest an extensive excretion of topiramate into breast milk.
Slovenian: Na voljo so omejeni podatki, ki kažejo obsežno izločanje topiramata v materino mleko tudi pri človeku.
English: A drug-drug interaction study conducted in healthy volunteers evaluated the steady-state pharmacokinetics of metformin and topiramate in plasma when metformin was given alone and when metformin and topiramate were given simultaneously.
Slovenian: V študiji medsebojnega delovanja zdravil, opravljeni pri zdravih prostovoljcih, so ovrednotili farmakokinetiko metformina in topiramata v plazmi v stanju dinamičnega ravnovesja, če so metformin uporabljali samostojno ali sočasno s topiramatom.
English: ADRs that were reported in children but not in adults in double-blind controlled studies include: eosinophilia, psychomotor hyperactivity, vertigo, vomiting, hyperthermia, pyrexia, and learning disability.
Slovenian: Neželeni učinki, o katerih so poročali samo pri otrocih in ne pri odraslih v dvojno slepih nadzorovanih preskušanjih: eozinofilija, psihomotorična hiperaktivnost, vrtoglavica, bruhanje, hipertermija, zvišana telesna temperatura in težave z učenjem.
English: 6.1 List of excipients [To be completed nationally] 6.2 Incompatibilities [To be completed nationally] 6.3 Shelf life [To be completed nationally]
Slovenian: 6.2 Inkompatibilnosti [Izpolni država članica]
English: It is important that you do not stop taking your medicine without first consulting your doctor.
Slovenian: Preden prenehate jemati zdravilo, se posvetujte z zdravnikom.
English: Therefore the CHMP considered that the use of topiramate as adjunctive therapy in adults with partial onset seizures with or without secondary generalization is supported.
Slovenian: Zato je CHMP uporabo topiramata kot dodatne terapije pri odraslih z napadi z delnim nastopom s sekundarno generalizacijo ali brez nje štel za podprto.
English: There is undoubtedly statistically significant evidence of efficacy seen in the paediatric population as a whole to support the adjunctive therapy indication in children with POS, PGTS, or LGS seizure types.
Slovenian: Nedvomno obstajajo statistično pomembni dokazi učinkovitosti v populaciji otrok kot celoti, ki podpirajo indikacijo dodatne terapije pri otrocih z napadi z delnim nastopom, primarnimi generaliziranimi tonično-kloničnimi napadi ali napadi, povezanimi z Lennox-Gastautovim sindromom.
English: Therapy should begin at 25-50 mg nightly for one week.
Slovenian: Zdravljenje naj se začne z odmerkom 25-50 mg zvečer za en teden.
English: There was a 25% reduction in glyburide AUC24 during topiramate administration.
Slovenian: Med jemanjem topiramata so opazili 25 % zmanjšanje vrednosti AUC24 za gliburid.
English: 20 hard capsules 28 hard capsules 50 hard capsules 60 hard capsules 100 hard capsules
Slovenian: 20 trdih kapsul 28 trdih kapsul 50 trdih kapsul 60 trdih kapsul 100 trdih kapsul
English: Erectile dysfunction, sexual dysfunction
Slovenian: Motnje reprodukcije in dojk motnje erekcije, spolne motnje
English: Following twice a day dosing with 50 mg and 100 mg of topiramate the mean renal clearance was approximately 18 ml/min and 17 ml/min, respectively.
Slovenian: Po jemanju 50 mg topiramata dvakrat na dan je znašal njegov srednji ledvični očistek približno 18 ml/min, po jemanju 100 mg topiramata dvakrat na dan je znašal približno 17 ml/min.
English: Topamax and associated names (see Annex I) 25 mg film-coated tablets Topamax and associated names (see Annex I) 50 mg film-coated tablets Topamax and associated names (see Annex I) 100 mg film-coated tablets Topamax and associated names (see Annex I) 200 mg film-coated tablets
Slovenian: Topamax in sorodna imena (glejte Dodatek I) 25 mg filmsko obložene tablete Topamax in sorodna imena (glejte Dodatek I) 50 mg filmsko obložene tablete Topamax in sorodna imena (glejte Dodatek I) 100 mg filmsko obložene tablete Topamax in sorodna imena (glejte Dodatek I) 200 mg filmsko obložene tablete
English: A drug-drug interaction study conducted in healthy volunteers evaluated the steady-state pharmacokinetics of HCTZ (25 mg q24h) and topiramate (96 mg q12h) when administered alone and concomitantly.
Slovenian: V študiji medsebojnega delovanja zdravil, opravljeni pri zdravih prostovoljcih, so ovrednotili farmakokinetiko HCTZ (25 mg na 24 ur) in topiramata (96 mg na 12 ur) v stanju dinamičnega ravnovesja pri ločeni in sočasni uporabi.
English: In addition, topiramate inhibits some isoenzymes of carbonic anhydrase.
Slovenian: Topiramat tudi zavira nekatere izoencime karboanhidraze.
English: • Glaucoma which is a blockage of fluid in the eye causing increased pressure in the eye, pain and decreased vision
Slovenian: • glavkom (ker očesna tekočina ne more iztekati se poveča tlak v očesu, pojavi se bolečina in zmanjšanje vida)
English: The recommended initial target dose for topiramate monotherapy in adults is 100 mg/day to 200 mg/day in 2 divided doses.
Slovenian: Priporočeni začetni ciljni odmerek za monoterapijo s topiramatom pri odraslih je 100-200 mg/dan, razdeljen na dva enaka odmerka.
English: Topamax can be taken without regard to meals.
Slovenian: Zdravilo Topamax lahko bolnik jemlje ne glede na obroke.
English: Crystal urine present, tandem gait test abnormal, white blood cell count decreased
Slovenian: prisotnost kristalov v seču, nenormalen izvid tandem testa hoje, zmanjšanje števila levkocitov zmanjšanje vrednosti hidrogenkarbo nata v krvi
English: In patients with moderate to severe hepatic impairment topiramate should be administered with caution as the clearance of topiramate is decreased.
Slovenian: Pri predpisovanju topiramata bolnikom z zmerno do resno jetrno okvaro je potrebna previdnost, ker je pri njih očistek topiramata zmanjšan.
English: In hepatically-impaired patients, topiramate should be administered with caution as the clearance of topiramate may be decreased.
Slovenian: Pri bolnikih z jetrno okvaro je treba topiramat uporabljati previdno, ker je pri njih očistek topiramata lahko zmanjšan.
English: This is seen to be supportive of the proposed indication of topimarate as adjunctive therapy for partial onset seizures with or without secondarily generalised seizures in the paediatric population.
Slovenian: To je štelo kot podpora predlagani indikaciji topiramata kot dodatne terapije za napade z delnim nastopom s sekundarno generalizacijo ali brez nje pri otrocih.
English: If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before using Topamax.
Slovenian: Če niste prepričani, ali katera od zgornjih navedb velja za vas, se posvetujte s svojim zdravnikom ali farmacevtom, preden začnete jemati zdravilo Topamax.
English: A determination should be made whether patients with history of eye disorders should be treated with topiramate.
Slovenian: Treba se je odločiti ali je zdravljenje s topiramatom primerno za bolnika z boleznimi očesa v pretekli anamnezi.
English: In rats, dosage-related maternal and embryo/fetal toxicity (reduced fetal weights and/or skeletal ossification) were observed down to 20 mg/kg/day with teratogenic effects (limb and digit defects) at 400 mg/kg/day and above.
Slovenian: Pri podganah so pri 20 mg/kg/dan opazili z odmerkom povezano toksičnost za samice in zarodek/plod (zmanjšana masa plodu in/ali zakostenevanje) ter teratogene učinke (okvare prstov ali okončin) pri 400 mg/kg/dan ali več.
English: • Toxic epidermal necrolysis which is a more severe form of Stevens-Johnson syndrome (see uncommon side effects).
Slovenian: • toksična razgradnja odmrle plasti kože, ki je resnejša od Stevens-Johnsonovega sindroma
English: The clinical significance of the changes observed is not known.
Slovenian: Klinični pomen opisanih sprememb ni znan.
English: Topiramate antagonized the ability of kainate to activate the kainate/AMPA (α -amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subtype of excitatory amino acid (glutamate) receptor, but had no apparent effect on the activity of N-methyl-Daspartate (NMDA) at the NMDA receptor subtype.
Slovenian: Topiramat je tudi zmanjšal sposobnost kainata za aktivacijo receptorjev za kainat/AMPA (α-amino-3-hidroksi-5-metilizoksazol-4-propionska kislina) - podtip ekscitatorne aminokisline (glutamat), ni pa imel vidnega vpliva na aktivnost N-metil-D-aspartata (NMDA) pri podtipu receptorjev za NMDA. Ti učinki topiramata so bili odvisni od koncentracije, v razponu od 1-μM do 200 μM, minimalno aktivnost pa so opazili pri 1 μM do 10 μM.
English: Belgium Janssen-Cilag NV - BE Roderveldlaan 1 B-2600 Berchem, Belgium
Slovenian: Janssen-Cilag NV - BE Roderveldlaan 1 B-2600 Berchem, Belgija
English: The most common ADRs (those with an incidence of >5% and greater than that observed in placebo in at least 1 indication in double-blind controlled studies with topiramate) include: anorexia, decreased appetite, bradyphrenia, depression, expressive language disorder, insomnia, coordination abnormal, disturbance in attention, dizziness, dysarthria, dysgeusia, hypoesthesia, lethargy, memory impairment, nystagmus, paresthesia, somnolence, tremor, diplopia, vision blurred, diarrhoea, nausea, fatigue, irritability, and weight decreased.
Slovenian: Najpogostejši neželeni učinki (incidenca > 5 % in večja incidenca kot pri placebu za najmanj 1 indikacijo v dvojno slepih nadzorovanih študijah s topiramatom): anoreksija, zmanjšan apetit, bradifrenija, depresija, motnja ekspresivnega govora, nespečnost, motnje koordinacije, zmanjšana pozornost, omotica, disartrija, disgevzija, hipoestezija, letargija, motnje spomina, nistagmus, parestezije, somnolenca, tremor, diplopija, zamegljen vid, driska, slabost, utrujenost, razdražljivost in hujšanje.
English: • Decrease or loss of sweating
Slovenian: • zmanjšanje ali izgubo sluha
English: • Impaired or distorted sense of smell
Slovenian: • okvarjen ali spremenjen voh
English: • Tingling or numbness of the mouth
Slovenian: • ščemenje ali otrplost v ustih
English: The majority of ADRs were mild to moderate in severity.
Slovenian: Po jakosti so bili neželeni učinki večinoma blagi do zmerni.
English: • Slurred speech
Slovenian: • upočasnjen govor
English: The addition of HCTZ to topiramate therapy may require an adjustment of the topiramate dose.
Slovenian: Pri dodatku HCTZ zdravljenju s topiramatom bo lahko potrebna prilagoditev odmerka topiramata.
English: Monotherapy epilepsy
Slovenian: Monoterapija epilepsije
English: Take special care with Topamax
Slovenian: Bodite posebno pozorni pri uporabi zdravila Topamax
English: Film-coated tablets
Slovenian: Filmsko obložena tableta Peroralna uporaba
English: Topiramate is not intended for acute treatment.
Slovenian: Topiramat ni namenjen akutnemu zdravljenju migrenskih glavobolov.
English: Consequently, the plasma concentrations of topiramate for the same mg/kg dose may be lower in children compared to adults.
Slovenian: Pri otrocih je očistek zdravila večji in njegova razpolovna doba krajša, zato so lahko pri njih plazemske koncentracije topiramata za isti odmerek v mg/kg manjše kot pri odraslih.
English: Monotherapy for epilepsy
Slovenian: Monoterapija za epilepsijo
English: Two metabolites, which retained most of the structure of topiramate, were tested and found to have little or no anticonvulsant activity.
Slovenian: Vsak od teh presnovkov predstavlja manj kot 3 % skupne radioaktivnosti, izločene po jemanju topiramata-C14. Testirali so dva presnovka, ki sta ohranila večino strukture topiramata, in ugotovili, da imata malo ali nič antikonvulzivnega delovanja.
English: Hydration can reduce the risk of nephrolithiasis (see below).
Slovenian: Med zdravljenjem s topiramatom je zelo pomembna zadostna hidracija bolnika, ki lahko zmanjša tveganje za nastanek nefrolitiaze (glejte spodaj).
English: The mean apparent volume of distribution was 0.80 to 0.55 l/kg for a single dose range of 100 to 1200 mg. An effect of gender on the volume of distribution was detected, with values for females circa 50% of those for males.
Slovenian: Njegov srednji navidezni porazdelitveni volumen je bil od 0,80 do 0,55 l/kg pri razponu enkratnih odmerkov od 100 do 1.200 mg.
English: You should call your doctor if you notice a change or decrease in your vision.
Slovenian: Če opazite spremembe ali zmanjšanje vida, obvestite zdravnika.
English: It is not necessary to monitor topiramate plasma concentrations to optimize therapy with Topamax.
Slovenian: Da bi dosegli optimalen učinek zdravljenja z zdravilom Topamax ni potrebno spremljati plazemskih koncentracij topiramata.
English: In animal studies, topiramate exhibits anticonvulsant activity in rat and mouse maximal electroshock seizure (MES) tests and is effective in rodent models of epilepsy, which include tonic and absence-like seizures in the spontaneous epileptic rat (SER) and tonic and clonic seizures induced in rats by kindling of the amygdala or by global ischemia.
Slovenian: Učinkovit je bil tudi pri glodalskih modelih epilepsije, v katerih so s stimulacijo amigdale ali s splošno ishemijo sprožali tonične epileptične napade in absencam podobne epileptične napade pri spontano epileptičnih podganah (SER) ter tonične in klonične epileptične napade pri podganah.
English: • have a history of blood and body fluid abnormality (metabolic acidosis)
Slovenian: • če ste kdaj v preteklosti imeli spremenjeno krvno sliko ali spremenjene vrednosti elektrolitov v telesnih tekočinah (metabolična acidoza),
English: Signs and symptoms included convulsions, drowsiness, speech disturbances, blurred vision, diplopia, impaired mentation, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression.
Slovenian: Med njegove znake in simptome sodijo konvulzije, zaspanost, motnje govora, zamegljen vid, diplopija, motnje mišljenja, letargija, motnje koordinacije, stupor, hipotenzija, trebušne bolečine, vznemirjenost, omotica in depresija.
English: • Renal tubular acidosis
Slovenian: • acidozo ledvičnih tubulov
English: • Skin discolouration
Slovenian: • razbarvanje kože
English: Therefore the harmonised indication for topiramate adjunctive therapy in partial onset seizures with or without secondary generalization or primary generalized tonic-clonic seizures in adults and in the paediatric population was supported by the CHMP:
Slovenian: Zato je CHMP podprl usklajeno indikacijo dodatne terapije s topiramatom za napade z delnim nastopom s sekundarno generalizacijo ali brez nje ali primarne generalizirane tonično-klonične napade pri odraslih bolnikih in pri otrocih:
English: • Increased acid levels in the blood
Slovenian: • povečano koncentracijo kislin v krvi (acidoza)
English: If the child is unable to tolerate the titration regimen, smaller increments or longer intervals between dose increments can be used.
Slovenian: Če otrok slabo prenaša to shemo zdravljenja, lahko uporabite tudi manjše odmerke ali daljše razmike med posameznimi povečanji odmerka.
English: An effective dose range of 200-400mg/day for adults was endorsed by the CHMP.
Slovenian: CHMP je za odrasle bolnike potrdil razpon učinkovitih odmerkov od 200 do 400 mg/dan.
English: Primidone
Slovenian: primidon
English: Avoid chewing.
Slovenian: • Navodilo shranite.
English: Approximately 66% of a dose of 14C-topiramate was excreted unchanged in the urine within four days.
Slovenian: V štirih dneh se je s sečem izločilo približno 66 % odmerka topiramata-C14
English: Suicidal ideation, suicide attempt, hallucination, psychotic disorder, hallucination auditory, hallucination visual, apathy, lack of spontaneous speech, sleep disorder, affect lability, libido decreased, restlessness, crying, dysphemia, euphoric mood, paranoia, perseveration, panic attack, tearfulness, reading disorder, initial insomnia, flat affect, thinking abnormal, loss of libido, listless, middle insomnia, distractibility, early morning awakening, panic reaction, elevated mood
Slovenian: samomorilne misli, poskus samomora, halucinacije, psihotične motnje, slišne halucinacije, vidne halucinacije, apatija, nezmožnost spontanega manija, anorgazmija, panična motnja, motnje spolnega vzburjenja, obupanost*, motnje orgazma hipomanija, , oslabljen vznemirjenost , nihanje razpoloženja, depresivno razpoloženje, jeza, nenormalno vedenje govora, motnje spanja, labilnost čustvovanja, zmanjšanje libida, nemir, jok, disfemija, evforično razpoloženje, paranoja, perseveracija, panični napadi, jokavost, motnje branja, nezmožnost zaspati, plitvo čustvovanje, nenormalno mišljenje, izguba libida, nemir, nespečnost sredi noči, hitro preusmerjanje pozornosti, zbujanje zgodaj zjutraj, panične reakcije, vzneseno razpoloženje orgazem
English: Partial onset seizures (POS) with or without secondary generalization in Adults and Children The results of 6 controlled studies indicate that adjunctive therapy in adults with topiramate has significant therapeutic benefit in controlling partial onset seizures with or without secondary generalisation.
Slovenian: Rezultati 6 kontroliranih študij kažejo, da ima dodatna terapija s topiramatom pri odraslih pomembno terapevtsko korist pri obvladovanju napadov z delnim nastopom s sekundarno generalizacijo ali brez nje.
English: An association of hyperammonemia with topiramate monotherapy or concomitant treatment with other anti-epileptics has not been established.
Slovenian: Razlog, zakaj se med monoterapijo s topiramatom ter pri njegovi sočasni uporabi z drugimi antiepileptiki pojavi hiperamonijemija še ni bil ugotovljen.
English: Topamax, when used concomitantly with other agents predisposing to nephrolithiasis, may increase the risk of nephrolithiasis.
Slovenian: Pri sočasni uporabi z drugimi zdravili, ki povečajo nagnjenost k nastanku nefrolitiaze, lahko zdravilo Topamax poveča tveganje za nefrolitiazo.
English: This effect was not blocked by flumazenil, a benzodiazepine antagonist, nor did topiramate increase the duration of the channel open time, differentiating topiramate from barbiturates that modulate GABAA receptors.
Slovenian: Zgoraj opisanega učinka topiramata ni mogel preprečiti flumazenil, antagonist benzodiazepinov, in topiramat tudi ni podaljšal časa odprtosti kanalčkov.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION [To be completed nationally]
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA
English: ADRs reported more frequently (≥2-fold) in children than in adults in double-blind controlled studies include: decreased appetite, increased appetite, acidosis hyperchloraemic, hypokalaemia, abnormal behaviour, aggression, apathy, initial insomnia, suicidal ideation, disturbance in attention, lethargy, circadian rhythm sleep disorder, poor quality sleep, lacrimation increased, sinus bradycardia, feeling abnormal, and gait disturbance.
Slovenian: Neželeni učinki, o katerih so v dvojno slepih nadzorovanih preskušanjih pogosteje poročali pri otrocih kot pri odraslih (≥ 2-krat): zmanjšanje apetita, povečanje apetita, hiperkloremična acidoza, hipokaliemija, nenormalno vedenje, agresivnost, apatija, nezmožnost zaspati, samomorilne misli, motnje pozornosti, letargija, motnje v cirkadianem ritmu spanja, slaba kakovost spanja, povečano solzenje, sinusna bradikardija, nenormalno počutje in motnje hoje.
English: • Swelling in the tissues around the eye
Slovenian: • oteklino okrog oči
English: Indication Migraine Prophylaxis
Slovenian: Profilaksa migrene
English: Indication Epilepsy
Slovenian: Uporaba pri epilepsiji
English: HOW TO TAKE TOPAMAX
Slovenian: KAKO JEMATI ZDRAVILO TOPAMAX
English: Adjunctive therapy epilepsy (partial onset seizures with or without secondary generalization, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut syndrome)
Slovenian: Dodatno zdravljenje epilepsije (pri parcialnih epileptičnih napadih z ali brez sekundarne generalizacije, primarno generaliziranih tonično-kloničnih napadih ali epileptičnih napadih v povezavi z Lennox-Gastautovim sindromom).
English: When Topamax is added or withdrawn in patients on digoxin therapy, careful attention should be given to the routine monitoring of serum digoxin.
Slovenian: Kadar dodajate ali ukinjate zdravilo Topamax pri bolnikih, ki se zdravijo z digoksinom, morate biti zelo pozorni na rutinsko spremljanje koncentracije digoksina v serumu.
English: If the patient is unable to tolerate the titration regimen, smaller increments or longer intervals between increments can be used.
Slovenian: Če bolnik slabo prenaša to shemo zdravljenja, lahko uporabite manjše odmerke ali pa daljše razmike med posameznimi povečanji odmerka.
English: • Disturbed or poor quality sleep
Slovenian: • motnje spanja ali slab spanec
English: • Hot flushing
Slovenian: • vročinske valove
English: A drug-drug interaction study conducted in healthy volunteers evaluated the steady-state pharmacokinetics of topiramate and pioglitazone when administered alone and concomitantly.
Slovenian: V študiji medsebojnega delovanja zdravil, opravljeni pri zdravih prostovoljcih, so ovrednotili farmakokinetiko topiramata in pioglitazona v stanju dinamičnega ravnovesja, kadar so ju uporabljali ločeno ali skupaj.
English: A syndrome consisting of acute myopia associated with secondary angle closure glaucoma has been reported in patients receiving topiramate.
Slovenian: Pri bolnikih, ki jemljejo topiramat, so poročali o sindromu, ki je sestavljen iz akutne miopije v povezavi s sekundarnim glavkomom zaprtega zakotja.
English: Dose and titration rate in children should be guided by clinical outcome.
Slovenian: Odmerek zdravila in hitrost prilagajanja odmerka pri otrocih sta odvisna od bolnikovega kliničnega odziva.
English: Topamax 50 mgGranulat in Kapseln granuals in capsule
Slovenian: Topamax 50 mgGranulat in Kapseln granule v kapsuli
English: Dose recommendations for the renally impaired have been stated.
Slovenian: Navedena so bila priporočila o odmerjanju za bolnike z okvarjenim delovanjem ledvic.