FrancophonIA/ELRC3.0 huggingface dataset:
English: No adverse interactions between either of the non-live vaccines and dupilumab were noted in the study.
Croatian: U ispitivanju nisu primijećene štetne interakcije između ijednog od dvaju neživih cjepiva i dupilumaba.
English: Very rarely, Dupixent can cause serious side effects, including allergic (hypersensitivity) reactions and anaphylactic reaction.
Croatian: U vrlo rijetkim slučajevima Dupixent može uzrokovati ozbiljne nuspojave, uključujući alergijske reakcije (reakcije preosjetljivosti) i anafilaktičku reakciju.
English: Median % reduction in daily OCS dose from baseline
Croatian: Medijan % smanjenja dnevne doze OKS-a od početne vrijednosti
English: If you need to permanently remove the carton from the refrigerator, write down the date of removal in the space provided on the outer carton, and use Dupixent within 14 days.
Croatian: Ako morate trajno izvaditi kutiju iz hladnjaka, zapišite datum kada ste je izvadili na za to namijenjenom mjestu na kutiji i upotrijebite Dupixent unutar 14 dana.
English: Both play a major role in causing the signs and symptoms of atopic dermatitis and asthma.
Croatian: Oba ta proteina igraju veliku ulogu u izazivanju znakova i simptoma atopijskog dermatitisa i astme.
English: Look at the medicine through the viewing window on the syringe:
Croatian: Pregledajte lijek kroz prozorčić za pregled na štrcaljki:
English: Mean AQLQ score (± SD)
Croatian: Srednja vrijednost AQLQ rezultata (± SD)
English: Dupilumab is a fully human monoclonal antibody against interleukin (IL)-4 receptor alpha that inhibits IL-4/IL-13 signalling, produced in Chinese Hamster Ovary (CHO) cells by recombinant DNA technology.
Croatian: Dupilumab je potpuno humano monoklonsko protutijelo protiv interleukin (IL)-4 receptora alfa koje inhibira signalizaciju putem IL-4/IL-13, proizvedeno u stanicama jajnika kineskog hrčka tehnologijom rekombinantne DNK.
English: • Check the expiration date.
Croatian: • Provjerite rok valjanosti.
English: The recommended dose of dupilumab for adolescent patients 12 to 17 years of age is specified in Table 1.
Croatian: Preporučena doza dupilumaba za adolescentne bolesnike u dobi od 12 do 17 godina navedena je u Tablici 1.
English: If you stop using Dupixent
Croatian: Ako prestanete primjenjivati Dupixent
English: 400 mg (two 200 mg injections)
Croatian: 400 mg (dvije injekcije od 200 mg)
English: Carcinogenicity studies have not been conducted with dupilumab.
Croatian: Nisu provedena ispitivanja kancerogenosti dupilumaba.
English: Conjunctivitis occurred more frequently in atopic dermatitis patients who received dupilumab.
Croatian: Konjunktivitis se javljao češće u bolesnika s atopijskim dermatitisom koji su primali dupilumab.
English: If you have forgotten to inject a dose of Dupixent, talk to your doctor, pharmacist or nurse.
Croatian: Ako ste zaboravili injicirati dozu lijeka Dupixent, obratite se svom liječniku, ljekarniku ili medicinskoj sestri.
English: After removing the 300 mg pre-filled syringe from the refrigerator, it should be allowed to reach room temperature by waiting for 45 min before injecting Dupixent.
Croatian: Nakon što se napunjena štrcaljka od 300 mg izvadi iz hladnjaka, treba pričekati 45 minuta da se ugrije na sobnu temperaturu prije nego što se Dupixent injicira.
English: Patients treated with dupilumab who develop conjunctivitis that does not resolve following standard treatment should undergo ophthalmological examination (section 4.8).
Croatian: U bolesnika liječenih dupilumabom u kojih se razvije konjunktivitis koji se ne povlači nakon standardnog liječenja potrebno je provesti oftalmološki pregled (vidjeti dio 4.8).
English: If you have asthma and are taking asthma medicines, do not change or stop your asthma medicine without talking to your doctor.
Croatian: Ako imate astmu i uzimate lijekove za nju, nemojte ih mijenjati niti prestati uzimati bez prethodnog razgovora sa svojim liječnikom.
English: Primary and secondary endpoints for the 16 week CAFE study are summarized in table 6.
Croatian: Primarna i sekundarne mjere ishoda u 16-tjednom ispitivanju CAFE sažeto su prikazane u Tablici 6.
English: A volume of distribution for dupilumab of approximately 4.6 L was estimated by population PK analysis, indicating that dupilumab is distributed primarily in the vascular system.
Croatian: Prema populacijskoj farmakokinetičkoj analizi, procijenjeni volumen distribucije dupilumaba iznosi približno 4,6 l, što ukazuje na to da se dupilumab prvenstveno raspodjeljuje u krvožilni sustav.
English: Dupixent contains the active substance dupilumab.
Croatian: Dupixent sadrži djelatnu tvar dupilumab.
English: The primary endpoint was the proportion of patients with EASI-75 at week 16.
Croatian: Primarna mjera ishoda bio je udio bolesnika s rezultatom EASI-75 u 16. tjednu.
English: Dupilumab should not be used to treat acute asthma symptoms or acute exacerbations.
Croatian: Dupilumab se ne smije koristiti za liječenje akutnih simptoma astme ili akutnih egzacerbacija.
English: Do not keep Dupixent at room temperature for more than 14 days.
Croatian: Nemojte čuvati Dupixent na sobnoj temperaturi dulje od 14 dana.
English: At Week 52
Croatian: U 52. tjednu
English: QUEST was a 52-week confirmatory study which included 1,902 patients (12 years of age and older).
Croatian: Ispitivanje QUEST bilo je 52-tjedno potvrdno ispitivanje koje je obuhvatilo 1902 bolesnika (u dobi od 12 ili više godina).
English: It is recommended to rotate the injection site with each injection.
Croatian: Preporučuje se mijenjati mjesto injiciranja kod svake injekcije.
English: 1 pre-filled syringe with needle shield 2 pre-filled syringes with needle shield Component of a multipack, can't be sold separately.
Croatian: 1 napunjena štrcaljka sa zaštitnim pokrovom igle 2 napunjene štrcaljke sa zaštitnim pokrovom igle Sastavni dio višestrukog pakiranja; ne može se prodavati odvojeno.
English: Helminth infection
Croatian: Infekcija helmintima
English: No dose adjustment is needed in patients with mild or moderate renal impairment.
Croatian: Nije potrebno prilagođavati dozu u bolesnika s blagim ili umjerenim oštećenjem funkcije bubrega.
English: The ACQ-5 and AQLQ(S) were also assessed in VENTURE and showed improvements similar to those in QUEST.
Croatian: U ispitivanju VENTURE također su se ocjenjivali rezultati upitnika ACQ-5 i AQLQ(S), za koje su zabilježena poboljšanja slična onima u ispitivanju QUEST.
English: Relax the pinch.
Croatian: Opustite nabor.
English: VENTURE evaluated the effect of dupilumab on reducing the use of maintenance oral corticosteroids.
Croatian: U ispitivanju VENTURE ocjenjivao se učinak dupilumaba na smanjenje primjene oralnih kortikosteroida za terapiju održavanja.
English: • Keep the pre-filled pen(s) and all medicines out of the reach of children.
Croatian: • Napunjenu brizgalicu/napunjene brizgalice i sve lijekove čuvajte izvan dohvata djece.
English: LS = least squares; SE = standard error a All patients were on background topical corticosteroids therapy and patients were permitted to use topical calcineurin inhibitors.
Croatian: SE = standardna pogreška a Svi bolesnici primali su osnovnu terapiju topikalnim kortikosteroidima, a bilo im je dopušteno koristiti i topikalne inhibitore kalcineurina.
English: Due to nonlinear clearance, dupilumab exposure, as measured by area under the concentration-time curve, increases with dose in a greater than proportional manner following single SC doses from 75600 mg.
Croatian: Zbog nelinearnog se klirensa izloženost dupilumabu, mjerena područjem ispod krivulje koncentracije kroz vrijeme, nakon jedne s.c. doze od 75 - 600 mg povećava više nego proporcionalno dozi.
English: The demographics and baseline characteristics of these 3 studies are provided in Table 5 below.
Croatian: Demografske i početne značajke u ta 3 ispitivanja navedene su u Tablici 5 u nastavku.
English: All Severe Exacerbations DRI12544 study Dupilumab
Croatian: Sve teške egzacerbacije Ispitivanje DRI12544 Dupilumab
English: If you forget to use Dupixent
Croatian: Ako ste zaboravili primijeniti Dupixent
English: In adolescents 12 years and older, it is recommended that Dupixent be administered by or under supervision of an adult.
Croatian: Preporučuje se da adolescentima u dobi od 12 ili više godina Dupixent injicira odrasla osoba ili da se lijek primijeni pod nadzorom odrasle osobe.
English: Look at the medicine in the syringe: Check if the liquid is clear and colourless to pale yellow.
Croatian: Pregledajte lijek u štrcaljki: Provjerite je li otopina bistra te bezbojna do blijedožuta.
English: • Do not use the pre-filled pen if the yellow cap is missing or not securely attached.
Croatian: • Nemojte upotrijebiti napunjenu brizgalicu ako žuti zatvarač nedostaje ili nije čvrsto pričvršćen.
English: Do not press or touch the orange needle cover with your fingers.
Croatian: Nemojte pritiskati niti prstima dodirivati narančasti pokrov igle.
English: The safety and efficacy of dupilumab in children with atopic dermatitis below the age of 12 years have not been established (see section 5.2).
Croatian: Sigurnost i djelotvornost dupilumaba u djece s atopijskim dermatitisom mlađe od 12 godina nisu ustanovljene (vidjeti dio 5.2).
English: CAFE study evaluated the efficacy of dupilumab compared to placebo during a 16-week treatment period, administered with concomitant TCS, in adult patients with AD who are not adequately controlled with, or are intolerant to, oral ciclosporin, or when this treatment is currently contraindicated or not medically advisable.
Croatian: U ispitivanju CAFE ocjenjivala se djelotvornost dupilumaba u odnosu na placebo tijekom 16-tjednog razdoblja liječenja, uz istodobnu primjenu topikalnih kortikosteroida, u odraslih bolesnika s atopijskim dermatitisom kojima stanje nije dovoljno dobro kontrolirano oralnim ciklosporinom ili koji ne podnose liječenje oralnim ciklosporinom ili kada je takvo liječenje u datom trenutku kontraindicirano ili nije medicinski preporučljivo.
English: Conjunctivitis related events
Croatian: Događaji povezani s konjunktivitisom
English: It is recommended that patients should be brought up to date with live and live attenuated immunisations in agreement with current immunisation guidelines prior to treatment with dupilumab.
Croatian: Preporučuje se da bolesnici dovrše cijepljenje živim i živim atenuiranim cjepivima prema važećem programu imunizacije prije početka liječenja dupilumabom.
English: Eligible patients enrolled into the three studies had previous inadequate response to topical medication.
Croatian: Bolesnici koji su ispunjavali kriterije i koji su uključeni u spomenuta tri ispitivanja prethodno nisu ostvarili dovoljno dobar odgovor na topikalne lijekove.
English: If the solution is cloudy, discoloured or contains visible particulate matter, the solution should not be used.
Croatian: Ako je otopina mutna, ako je promijenila boju ili sadrži vidljive čestice, ne smije se upotrijebiti.
English: The pharmacokinetics of dupilumab in paediatric patients (< 12 years of age) with atopic dermatitis has not been studied.
Croatian: Nije se ispitivala farmakokinetika dupilumaba u pedijatrijskih bolesnika (u dobi od < 12 godina) s atopijskim dermatitisom.
English: Insert the needle into the fold of skin at roughly a 45º angle.
Croatian: Ubodite iglu u nabor kože pod kutom od približno 45º.
English: Dupilumab has no or negligible influence on the ability to drive or operate machinery.
Croatian: Dupilumab ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: 600 mg (two 300 mg injections)
Croatian: 600 mg (dvije injekcije od 300 mg)
English: In this study, the mean age was 14.5 years, the median weight was 59.4 kg, 41.0 % were female, 62.5% were White, 15.1% were Asian, and 12.0% were Black.
Croatian: U ovom ispitivanju srednja vrijednost dobi iznosila je 14,5 godina, srednja vrijednost tjelesne težine 59,4 kg, 41,0% bolesnika bile su žene, 62,5% bili su bijelci, 15,1% Azijati, a 12,0% bolesnika crnci.
English: The demographics and baseline characteristics of these 3 studies are provided in Table 11 below.
Croatian: Demografske i početne značajke u ta 3 ispitivanja navedene su u Tablici 11 u nastavku.
English: Based on the population analysis, commonly co-administered medications had no effect on dupilumab pharmacokinetics on patients with moderate to severe asthma.
Croatian: Prema populacijskoj analizi, lijekovi koji se često primjenjuju istodobno nisu utjecali na farmakokinetiku dupilumaba u bolesnika s umjerenom do teškom astmom.
English: Dupilumab is a recombinant human IgG4 monoclonal antibody that inhibits interleukin-4 and interleukin-13 signaling.
Croatian: Dupilumab je rekombinantno humano IgG4 monoklonsko protutijelo koje inhibira signalizaciju putem interleukina-4 i interleukina-13.
English: • Do not get rid of any air bubbles in the syringe.
Croatian: • Nemojte uklanjati mjehuriće zraka iz štrcaljke.
English: STATEMENT OF ACTIVE SUBSTANCE(S)
Croatian: LS srednja vrijednost razlike (SE)
English: DLQI, LS mean change from baseline (SE) (all p values <0.0001)
Croatian: DLQI, LS srednja vrijednost promjene od početne vrijednosti (SE) (sve p-vrijednosti < 0,0001)
English: Clinical efficacy and safety in atopic dermatitis
Croatian: Klinička djelotvornost i sigurnost kod atopijskog dermatitisa
English: Tell your doctor or pharmacist - if you are using, have recently used or might use any other medicines.
Croatian: - ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove - ako ste nedavno primili ili trebate primiti cjepivo
English: After removing the 200 mg pre-filled syringe or pre-filled pen from the refrigerator, it should be allowed to reach room temperature by waiting for 30 min before injecting Dupixent.
Croatian: Nakon što se napunjena štrcaljka ili napunjena brizgalica od 200 mg izvadi iz hladnjaka, treba pričekati 30 minuta da se ugrije na sobnu temperaturu prije nego što se Dupixent injicira.
English: • Do not press or touch the orange needle cover with your fingers.
Croatian: • Nemojte pritiskati niti prstima dodirivati narančasti pokrov igle.
English: Genzyme Flanders BVBA Cipalstraat 8, B-2440 Geel
Croatian: Genzyme Flanders BVBA Cipalstraat 8
English: Step 3: Inspect
Croatian: 3. korak: Pregledajte lijek
English: Dupilumab can be used with or without topical corticosteroids.
Croatian: Dupilumab se može primjenjivati zajedno s topikalnim kortikosteroidima ili bez njih.
English: b FAS week 52 includes all patients randomized at least one year before the cutoff date of the primary analysis.
Croatian: b FAS populacija iz 52. tjedna uključuje sve bolesnike randomizirane najmanje jednu godinu prije završnog datuma prikupljanja podataka za primarnu analizu.
English: Insert the Needle completely into the fold of skin at roughly a 45º angle.
Croatian: Ubodite iglu cijelom dužinom u nabor kože pod kutom od približno 45º.
English: Clean the injection site with an alcohol wipe.
Croatian: Očistite mjesto injiciranja vaticom natopljenom alkoholom.
English: The adverse event profile in adolescents was generally similar to the adults.
Croatian: Profil nuspojava u adolescenata u načelu je bio sličan onome u odraslih.
English: N Responder rate (%)
Croatian: Udio ispitanika (%)
English: • Stomach except for the 5 cm around your belly button (navel).
Croatian: • trbuh, osim područja 5 cm oko pupka
English: Severity Index (EASI) score ≥16, and a minimum body surface area (BSA) involvement of ≥ 10 %.
Croatian: Eczema Area and Severity Index, EASI) i minimalna zahvaćenost tjelesne površine ≥ 10%.
English: In the pooled analysis of DRI12544 and QUEST, hospitalizations and/or emergency room visits due to severe exacerbations were reduced by 25.5% and 46.9% with dupilumab 200 mg or 300 mg every other week, respectively.
Croatian: Prema analizi objedinjenih podataka iz ispitivanja DRI12544 i QUEST, stopa hospitalizacija i/ili posjeta hitnoj službi zbog teških egzacerbacija smanjila se za 25,5% i 46,9% uz dupilumab u dozi od 200 mg odnosno 300 mg svaki drugi tjedan.
English: Dupilumab should not be injected into skin that is tender, damaged or has bruises or scars.
Croatian: Dupilumab se ne smije injicirati u kožu koja je osjetljiva na dodir, oštećena ili prekrivena modricama ili ožiljcima.
English: Dupilumab inhibits IL-4 signaling via the Type I receptor (IL-4Rα/γc), and both IL-4 and IL-13 signaling through the Type II receptor (IL-4Rα/IL-13Rα).
Croatian: Dupilumab inhibira signalizaciju putem interleukina-4 preko receptora tipa I (IL-4Rα/γc) te signalizaciju putem interleukina-4 i interleukina-13 preko receptora tipa II (IL-4Rα/IL-13Rα).
English: Listed in Table 3 are adverse reactions observed in asthma clinical trials presented by system organ class and frequency, using the following categories: very common (≥ 1/10); common (≥ 1/100 to
Croatian: Tablici 3 navode se nuspojave primijećene u kliničkim ispitivanjima kod astme, prikazane prema organskim sustavima i učestalosti, sukladno sljedećim kategorijama: vrlo često (≥ 1/10); često
English: Effects on lung function, on oral steroid and exacerbation reduction were similar irrespective of baseline levels of type 2 inflammatory biomarkers (e.g. blood eosinophils, FeNO).
Croatian: Učinci na plućnu funkciju, smanjenje doze oralnih steroida i smanjenje stope egzacerbacija bili su slični neovisno o početnim vrijednostima bioloških biljega upale tipa 2 (npr. eozinofila u krvi, FeNO).
English: Eligible patients enrolled into this study had previous inadequate response to topical medication.
Croatian: Bolesnici koji su ispunjavali kriterije i koji su uključeni u ovo ispitivanje prethodno nisu ostvarili dovoljno dobar odgovor na topikalne lijekove.
English: • Clean the injection site with an alcohol wipe.
Croatian: • Očistite mjesto injiciranja vaticom natopljenom alkoholom.
English: Quality of Life/Patient-Reported Outcomes in Atopic Dermatitis
Croatian: Kvaliteta života/ishodi koje prijavljuju bolesnici kod atopijskog dermatitisa
English: The safety and efficacy of dupilumab in children with severe asthma below the age of 12 years have not been established (see section 5.2).
Croatian: Sigurnost i djelotvornost dupilumaba u djece s teškom astmom mlađe od 12 godina nisu ustanovljene (vidjeti dio 5.2).
English: 1 pre-filled pen 2 pre-filled pens 3 pre-filled pens 6 pre-filled pens
Croatian: 1 napunjena brizgalica 2 napunjene brizgalice 3 napunjene brizgalice 6 napunjenih brizgalica
English: • Do not shake the syringe at any time.
Croatian: • Nemojte tresti štrcaljku ni u jednom trenutku.
English: After 12 weeks of dupilumab administration, patients were vaccinated with a Tdap vaccine (T cell-dependent), and a meningococcal polysaccharide vaccine (T cell-independent) and immune responses were assessed 4 weeks later.
Croatian: 12 tjedana primjene dupilumaba bolesnici su bili cijepljeni cjepivom Tdap (ovisnim o T-stanicama) i meningokoknim polisaharidnim cjepivom (neovisnim o T-stanicama), a imuni odgovori ocjenjivali su se 4 tjedna kasnije.
English: In asthma clinical trials, dupilumab treatment markedly decreased FeNO and circulating concentrations of eotaxin-3, total IgE, allergen specific IgE, TARC, and periostin in asthma subjects relative to placebo.
Croatian: U kliničkim ispitivanjima kod astme liječenje dupilumabom je u ispitanika s astmom dovelo do izraženog smanjenja razine FeNO i cirkulirajućih koncentracija eotaksina-3, ukupnog IgE-a, IgE-a specifičnog za pojedini alergen, TARC-a i periostina u odnosu na placebo.
English: The pharmacokinetics of dupilumab is similar in patients with atopic dermatitis and asthma.
Croatian: 5.2 Farmakokinetička svojstva Farmakokinetika dupilumaba slična je u bolesnika s atopijskim dermatitisom i astmom.
English: • If somebody else gives you the injection, they can also use your upper arm.
Croatian: • Ako Vam injekciju daje netko drugi, ona se može primijeniti i u nadlakticu.
English: • Change the injection site for each injection.
Croatian: • Promijenite mjesto injiciranja kod svake injekcije.
English: Consideration should be given to discontinuing treatment in patients who have shown no response after 16 weeks of treatment for atopic dermatitis.
Croatian: U bolesnika koji ne ostvare nikakav odgovor nakon 16 tjedana liječenja atopijskog dermatitisa treba razmotriti prekid liječenja.
English: A total of 107 adolescents aged 12 to 17 years with asthma were enrolled in QUEST study.
Croatian: Ukupno je 107 adolescenata u dobi od 12 do 17 godina bilo uključeno u ispitivanje QUEST.
English: LS Mean Difference vs. placebo (95% CI)
Croatian: LS srednja vrijednost razlike u odnosu na placebo (95% CI)
English: The long-term efficacy of dupilumab in adolescent patients with moderate-to-severe AD who had participated in previous clinical trials of dupilumab was assessed in open-label extension study (AD1434).
Croatian: Dugoročna djelotvornost dupilumaba u adolescenata s umjerenim do teškim atopijskim dermatitisom koji su sudjelovali u prethodnim kliničkim ispitivanjima za dupilumab bila je ocijenjena u otvorenom nastavku ispitivanja (AD-1434).
English: Dupixent contains sodium
Croatian: Dupixent sadrži natrij
English: Talk to your doctor before you stop Dupixent or if your asthma remains uncontrolled or worsens during treatment with this medicine.
Croatian: Dupixent ili ako Vam astma i dalje nije pod kontrolom ili se pogorša tijekom liječenja ovim lijekom.
English: In the overall population in DRI12544 and QUEST subjects receiving either dupilumab 200 mg or 300 mg every other week had significant reductions in the rate of severe asthma exacerbations compared to placebo.
Croatian: U cjelokupnoj populaciji bolesnika iz ispitivanja DRI12544 i QUEST, ispitanici koji su primali dupilumab u dozi od 200 mg ili 300 mg svaki drugi tjedan ostvarili su značajno smanjenje stope teških egzacerbacija astme u usporedbi s placebom.
English: Dupilumab-treated patients had a greater mean initial increase from baseline in eosinophil count compared to patients treated with placebo.
Croatian: Bolesnici liječeni dupilumabom imali su veću srednju vrijednost inicijalnog porasta početnog broja eozinofila nego bolesnici koji su primali placebo.
English: PHARMACEUTICAL PARTICULARS 6.1 List of excipients arginine hydrochloride histidine polysorbate 80 sodium acetate trihydrate glacial acetic acid sucrose water for injections
Croatian: 6.1 Popis pomoćnih tvari argininklorid histidin polisorbat 80 natrijev acetat trihidrat ledena acetatna kiselina saharoza voda za injekcije
English: • Store pre-filled pens in the original carton to protect it from light.
Croatian: • Napunjene brizgalice čuvajte u originalnom pakiranju radi zaštite od svjetlosti.
English: Pull the yellow cap straight off.
Croatian: Povucite žuti zatvarač ravno s brizgalice.
English: Select the injection site.
Croatian: Odaberite mjesto injiciranja.
English: Table 11: Demographics and Baseline Characteristics of Asthma Trials
Croatian: Tablica 11: Demografske i početne značajke u ispitivanjima kod astme
English: • Keep unused syringes in the original carton and store in the refrigerator between 2ºC and 8ºC.
Croatian: • Neupotrijebljene štrcaljke držite u originalnom pakiranju i čuvajte u hladnjaku na temperaturi od 2ºC do 8ºC.
English: Anti-Drug-Antibodies (ADA) responses were not generally associated with impact on dupilumab exposure, safety, or efficacy.
Croatian: Stvaranje protutijela na lijek u načelu nije bilo povezano s utjecajem na izloženost dupilumabu, njegovu sigurnost ni djelotvornost.
English: Table 5: Demographics and Baseline Characteristics of Asthma Trials
Croatian: Tablica 5: Demografske i početne značajke u ispitivanjima kod astme
English: The safety of dupilumab was evaluated in four randomized, double-blind, placebo-controlled studies and one dose-ranging study in patients with moderate-to-severe atopic dermatitis.
Croatian: Tablični prikaz nuspojava Sigurnost dupilumaba ocjenjivala se u četiri randomizirana, dvostruko slijepa, placebom kontrolirana ispitivanja i u jednom ispitivanju raspona doza u bolesnika s umjerenim do teškim atopijskim dermatitisom.
English: Eosinophil counts declined to near baseline levels during study treatment.
Croatian: Broj eozinofila pao je gotovo na početnu vrijednost tijekom liječenja u sklopu ispitivanja.