FrancophonIA/ELRC3.0 huggingface dataset:
English: Pleural effusions and ascites should be drained prior to initiation of methotrexate treatment.
Romanian: Exsudatele pleurale şi ascita trebuie drenate înainte de iniţierea tratamentului cu metotrexat.
English: How to store Nordimet
Romanian: Cum se păstrează Nordimet
English: Uncommon: Photosensitisation, loss of hair, increase in rheumatic nodules, skin ulcer, herpes zoster, vasculitis, herpetiform eruptions of the skin, urticaria.
Romanian: Mai puţin frecvente: fotosensibilitate, alopecie, creşterea nodulilor reumatici, ulcerații ale pielii, herpes zoster, vasculită, erupţii herpetiforme cutanate, urticarie.
English: Concomitant administration of folate antagonists such as trimethoprim /sulphamethoxazole has been reported to cause an acute megaloblastic pancytopenia in rare instances.
Romanian: S-a raportat că administrarea concomitentă de antagonişti de acid folic cum sunt trimetoprimul/sulfametoxazolul determină, în cazuri rare, pancitopenie megaloblastică acută.
English: In cases of possible renal impairment (e.g. in elderly patients), closer monitoring is required.
Romanian: În cazurile în care funcţia renală poate fi compromisă (de exemplu, la vârstnici), monitorizarea trebuie să aibă loc mai frecvent.
English: Bleeding from the lungs, bone damage in the jaw (secondary to excessive growth of white blood cells), tissue destruction at injection site.
Romanian: Cu frecvență necunoscută (frecvența nu poate fi estimată din datele disponibile): sângerare la nivelul plămânilor, lezarea osului maxilarului (secundară înmulțirii exagerate a celulelor albe ale sângelui), distrugerea țesutului la locul de injectare.
English: This includes any possible side effects not listed in this leaflet.
Romanian: Acestea includ orice posibile reacţii adverse nemenţionate în acest prospect.
English: Depending on the individual activity of the disease and patient tolerability, the initial dose may be increased.
Romanian: În funcţie de gradul individual de activitate a bolii şi de tolerabilitatea fiecărui pacient, doza iniţială poate fi crescută.
English: Treatment of overdose
Romanian: Abordarea terapeutică a supradozajului
English: Men should not donate semen during therapy or for 6 months following discontinuation of methotrexate.
Romanian: Bărbații nu trebuie să doneze spermă în timpul tratamentului cu metotrexat și timp de 6 luni după întreruperea acestuia,
English: Uncommon: Gastrointestinal ulcers and bleeding, enteritis, vomiting, pancreatitis.
Romanian: Mai puţin frecvente: ulcere și sângerare gastro-intestinală, enterită, vărsături, pancreatită.
English: Though the combination of methotrexate and sulfasalazine may enhance methotrexate efficacy by sulfasalazine related inhibition of folic acid synthesis, and thus may lead to an increased risk of adverse reactions, these were only observed in single patients within several trials.
Romanian: Deşi asocierea metotrexatului cu sulfasalazina poate cauza o creştere a eficacităţii metotrexatului şi, prin urmare, o creştere a reacţiilor adverse cauzate de inhibarea sintezei de acid folic pe care o exercită sulfasalazina, asemenea reacţii adverse au fost observate numai în cazuri individuale rare, în cadrul câtorva studii.
English: Contraception in males
Romanian: Contracepția la bărbați
English: Overdose symptoms may include easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, coughing up blood or vomit that looks like coffee grounds, and decreased urinating.
Romanian: Simptomele de supradozare pot include învinețire ușoară sau sângerări, senzație de slăbiciune neobișnuită, ulcerații la nivelul gurii, greață, vărsături, scaune negre sau cu sânge, tuse cu sânge sau vărsătură cu aspect de zaț de cafea și scădere a urinatului.
English: - Examination of the oral cavity and throat for mucosal changes.
Romanian: - Examinarea cavităţii bucale şi a gâtului, pentru observarea modificărilor apărute pe mucoase.
English: Symptoms include leukocytopenia, thrombocytopenia, anaemia, pancytopenia, neutropenia, bone marrow depression, mucositis, stomatitis, oral ulceration, nausea, vomiting, gastrointestinal ulceration and gastrointestinal bleeding.
Romanian: Simptomatologia cuprinde leucocitopenie, trombocitopenie, anemie, pancitopenie, neutropenie, deprimarea măduvei oasoase, mucozită, stomatită, ulcerații la nivelul cavității orale, greață, vărsături, ulcerații și sângerări gastrointestinale.
English: As methotrexate is predominantly excreted via the renal route, increased concentrations can be expected in cases of renal impairment, which may result in severe adverse reactions.
Romanian: Deoarece metotrexatul se elimină în principal pe cale renală, este de aşteptat apariţia unor concentraţii plasmatice crescute în caz de insuficienţă renală, ceea ce poate determina reacţii adverse severe.
English: Keep the pen in the outer carton in order to protect from light.
Romanian: A se ține stiloul injector în cutie, pentru a fi protejat de lumină.
English: Incorrect dosing of methotrexate may lead to serious adverse effects which may be fatal.
Romanian: Administrarea incorectă a metotrexatului poate produce reacții adverse severe, care pot fi fatale.
English: In patients concomitantly taking haematotoxic medicinal products (e.g. leflunomide), the blood count and platelets should be closely monitored.
Romanian: Pacienţii care utilizează concomitent medicamente hematotoxice (de exemplu leflunomidă) trebuie să fie monitorizaţi îndeaproape din punct de vedere al hemoleucogramei şi numărului de plachete sanguine.
English: Acute bleeding from the lungs in patients with underlying rheumatologic disease has been reported with methotrexate.
Romanian: Episoade apărute brusc de sângerări la nivelul plămânilor au fost raportate la pacienți cu boală reumatologică preexistentă, în asociere cu tratamentul cu metotrexat.
English: Pre-filled syringes of 0.4 ml containing 10 mg methotrexate Pre-filled syringes of 0.5 ml containing 12.5 mg methotrexate Pre-filled syringes of 0.6 ml containing 15 mg methotrexate Pre-filled syringes of 0.7 ml containing 17.5 mg methotrexate Pre-filled syringes of 0.8 ml containing 20 mg methotrexate Pre-filled syringes of 0.9 ml containing 22.5 mg methotrexate Pre-filled syringes of 1.0 ml containing 25 mg methotrexate
Romanian: Stilou injector preumplut cu 0,3 ml soluție care conține metotrexat 7,5 mg Stilou injector preumplut cu 0,4 ml soluție care conține metotrexat 10 mg Stilou injector preumplut cu 0,5 ml soluție care conține metotrexat 12,5 mg Stilou injector preumplut cu 0,6 ml soluție care conține metotrexat 15 mg Stilou injector preumplut cu 0,7 ml soluție care conține metotrexat 17,5 mg Stilou injector preumplut cu 0,8 ml soluție care conține metotrexat 20 mg Stilou injector preumplut cu 0,9 ml soluție care conține metotrexat 22,5 mg Stilou injector preumplut cu 1,0 ml soluție care conține metotrexat 25 mg
English: Symptoms may return if treatment with Nordimet is stopped.
Romanian: Atunci când tratamentul cu Nordimet este întrerupt, simptomele pot reapărea.
English: • Obligation to conduct post-authorisation measures The MAH shall complete, within the stated timeframe, the below measures: Description
Romanian: DAPP trebuie să finalizeze, în intervalul de timp specificat, următoarele măsuri:
English: Pre-filled pen with a 1 mL type I glass syringe with attached stainless steel needle and a chlorobutyl rubber plunger stopper.
Romanian: Stilou injector preumplut care conține o seringă preumplută din sticlă de tip I de 1 ml, prevăzută cu ac atașat de oțel inoxidabil și un piston cu dop de cauciuc clorobutilic.
English: If women of a sexually mature age are treated, effective contraception must be performed during treatment and for at least six months after.
Romanian: În cazul tratamentului aplicat femeilor aflate la vârsta maturității sexuale, trebuie instituite măsuri eficace de contracepţie pe durata tratamentului şi timp de cel puţin şase luni după întreruperea acestuia.
English: Nordimet 22.5 mg solution for injection methotrexate
Romanian: Nordimet 22,5 mg soluție injectabilă metotrexat
English: In the treatment of rheumatoid arthritis, active juvenile idiopathic arthritis,psoriasis and psoriatic arthritis requiring dosing once a week.
Romanian: În tratamentul artritei reumatoide, al artritei juvenile idiopatice active, al psoriazisului și al artritei psoriazice care necesită administrare o dată pe săptămână, Nordimet trebuie administrat doar o dată pe săptămână.
English: Nordimet 17.5 mg solution for injection methotrexate
Romanian: Nordimet 17,5 mg soluție injectabilă metotrexat
English: Blister - PRE-FILLED SYRINGE
Romanian: Stiloul injector preumplut
English: The average weekly dose is 15-20 mg. Generally, a weekly dose of 25 mg should not be exceeded.
Romanian: Doza medie săptămânală este de 15-20 mg.
English: Nordimet 20 mg solution for injection methotrexate
Romanian: Nordimet 20 mg soluție injectabilă metotrexat
English: Nordimet 12.5 mg solution for injection methotrexate
Romanian: Nordimet 12,5 mg soluție injectabilă metotrexat
English: Nordimet 7.5 mg solution for injection methotrexate
Romanian: Nordimet 7,5 mg soluție injectabilă metotrexat
English: Keep the syringe in the outer carton in order to protect from light.
Romanian: A se ține seringa în cutie, pentru a fi protejată de lumină.
English: Decrease in the number of blood cells and platelets , dizziness, confusion, depression, fits, inflammation of blood vessels, lung damage, ulcers and bleeding in the digestive tract, liver disorders, diabetes, decreased blood protein, nettle rash, light sensitivity, brown skin, hair loss, increase of rheumatic nodules, shingles, painful psoriasis, joint or muscle pain, osteoporosis (reduction of bone mass), inflammation and ulcers of the bladder (possibly with blood in the urine), painful urination, severe allergic reactions, inflammation and ulcers of the vagina, slow wound healing.
Romanian: Mai puțin frecvente (pot afecta până la 1 persoană din 100): scădere a numărului de celule și plachete sanguine, amețeli, confuzie, depresie, crize convulsive, inflamare a vaselor de sânge, afectare a plămânului, ulcere și sângerări la nivelul tubului digestiv, tulburări la nivelul ficatului, diabet zaharat, scădere a proteinelor din sânge, urticarie, sensibilitate crecută la lumină, colorare brună a pielii, cădere a părului, creștere a numărului de noduli reumatoizi, zona zoster, psoriazis dureros, durere articulară sau musculară, osteoporoză (scădere a masei osoase), inflamație și ulcere la nivelul vezicii urinare (posibil însoțite de sânge în urină), urinat dureros, reacții alergice severe, inflamație și ulcerații la nivelul vaginului, vindecare încetinită a rănilor.
English: PRE-FILLED SYRINGE CARTON OUTER LABEL CONTAINS BLUE BOX
Romanian: INFORMAŢII CARE TREBUIE SĂ APARĂ PE AMBALAJUL SECUNDAR STILOU INJECTOR (PEN) PREUMPLUT CUTIE ETICHETA CONȚINE CHENAR ALBASTRU
English: Very rare: Hepatic failure.
Romanian: Foarte rare: insuficienţă hepatică.
English: - If you get any side effects, talk to your doctor or pharmacist.
Romanian: - Dacă manifestaţi orice reacţii adverse, adresaţi-vă medicului dumneavoastră sau farmacistului.
English: Nordimet 10 mg solution for injection methotrexate
Romanian: Nordimet 10 mg soluție injectabilă metotrexat
English: Not known: Osteonecrosis of jaw (secondary to lymphoproliferative disorders)
Romanian: Cu frecvență necunoscută: osteonecroză mandibulară (secundară tulburărilor limfoproliferative).
English: Nordimet 25 mg solution for injection methotrexate
Romanian: Nordimet 25 mg soluție injectabilă metotrexat
English: The skin on the front side abdominal wall and the skin at the front of the thigh are suitable as injection sites.
Romanian: Se recomandă ca sedii de injectare pielea de pe fața peretelui abdomenului și pielea de pe fața anterioară a coapsei.
English: Nordimet 15 mg solution for injection methotrexate
Romanian: Nordimet 15 mg soluție injectabilă metotrexat
English: Particular caution should therefore also be exercised in the presence of existing folic acid deficiency.
Romanian: Prin urmare, se recomandă o deosebită prudenţă în condiţiile existenţei unui deficit de acid folic.
English: Nordimet 20 mg solution for injection in pre-filled pen Each pre-filled pen contains 20 mg methotrexate in 0.8 mL
Romanian: Nordimet 20 mg soluţie injectabilă în stilou injector (pen) preumplut Fiecare stilou injector preumplut cu 0,8 ml soluție conține metotrexat 20 mg.
English: An overactive immune system has been linked to inflammatory diseases.
Romanian: Există legătură între un sistem imunitar activ în mod excesiv și afecțiunile inflamatorii.
English: In the event of contamination, the affected area must be rinsed immediately with ample amount of water.
Romanian: În caz de contaminare, părțile afectate se vor clăti imediat cu apă din abundenţă.
English: In rheumatological indications, there is no evidence to support use of liver biopsies in monitoring hepatotoxicity.
Romanian: Nu există dovezi care să susţină necesitatea utilizării biopsiei hepatice pentru monitorizarea toxicităţii hepatice în indicaţiile reumatologice.
English: Infections, severe failure of the bone marrow, liver failure, swollen glands, sleeplessness, pain, muscle weakness, pins and needles, changes in sense of taste (metallic taste), inflammation of the lining of the brain causing paralysis or vomiting, red eyes, damage to the retina of the eye, fluid in the lungs, vomiting blood, cold sores, protein in the urine, fever, loss of sex drive, problems having an erection, infection around a fingernail, severe complications of the gastrointestinal tract, boils, small blood vessels in the skin, fungal infections, damage to the blood vessels of the skin, vaginal discharge, infertility, male breast enlargement (gynaecomastia), inflammation of the brain, lymphoproliferative disorders (excessive growth of white blood cells).
Romanian: Foarte rare (pot afecta până la 1 persoană din 10000): infecții, insuficiență severă a măduvei osoase, insuficiență hepatică, tumefiere a glandelor, insomnie, durere, slăbiciune musculară, înțepături și furnicături, modificare a gustului (gust metalic), inflamație a învelișului creierului care poate produce paralizie sau vărsături, ochi roșii, afectare a retinei (retinopatie), acumulare de lichide în plămâni, vărsături cu sânge, herpes, proteine în urină, febră, pierdere a apetitului sexual, impotență, infecție în jurul unghiilor, complicații severe la nivelul tubului digestiv, abcese, afectare a vaselor mici de sânge din piele, secreții vaginale, infertilitate, mărire în volum a sânilor la bărbați (ginecomastie), inflamație a creierului, tulburări limfoproliferative (înmulțire excesivă a celulelor albe ale sângelui).
English: Side effects affecting the central nervous system, such as tiredness and dizziness, may occur during treatment with Nordimet.
Romanian: Tratamentul cu Nordimet poate provoca reacţii adverse care afectează sistemul nervos central, de exemplu oboseală şi ameţeli.
English: - Complete blood count with differential blood count and platelets.
Romanian: - Hemoleucograma completă cu formula leucocitară şi cu determinarea plachetelor sanguine.
English: If your doctor considers treatment with methotrexate absolutely necessary during the lactation period, you must stop breast-feeding.
Romanian: Va trebui să întrerupeți alăptarea dacă medicul dumneavoastră consideră că tratamentul cu metotrexat este absolut necesar în timpul perioadei de lactație.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING
Romanian: INFORMAŢII CARE TREBUIE SĂ APARĂ PE AMBALAJUL SECUNDAR SERINGĂ PREUMPLUTĂ CUTIE
English: Nordimet 22.5 mg solution for injection in pre-filled pen Each pre-filled pen contains 22.5 mg methotrexate in 0.9 mL
Romanian: Nordimet 22,5 mg soluţie injectabilă în stilou injector (pen) preumplut Fiecare stilou injector preumplut cu 0,9 ml soluție conține metotrexat 22,5 mg.
English: The recommended initial dose is 7.5 mg methotrexate once weekly.
Romanian: Doza inițială recomandată este de 7,5 mg metotrexat o dată pe săptămână.
English: EU/1/16/1124/049 - 12 pack
Romanian: EU/1/16/1124/049 - 12 cutii
English: In the event of any significant drop in leukocytes or platelets, treatment must be discontinued immediately and appropriate supportive therapy instituted.
Romanian: Orice scădere marcată a numărului de leucocite sau de plachete sanguine indică necesitatea întreruperii imediate a administrării medicamentului şi instituirea unui tratament de susţinere adecvat.
English: See section 4.
Romanian: Administrare subcutanată.
English: You will receive appropriate training for you to do this.
Romanian: Veţi primi pregătirea necesară pentru a face acest lucru.
English: EU/1/16/1124/027 - 6 pack
Romanian: EU/1/16/1124/027 - 6 cutii
English: Inflammation of the sac around the heart, fluid in the sac around the heart, severe visual disturbance, mood fluctuations, low blood pressure, blood clots, sore throat, interruption of breathing, asthma, inflammation of the digestive tract, bloody stools, inflamed gums, abnormal digestion, acute hepatitis (inflammation of the liver), changed colour of nails, acne, red or purple spots due to vessel bleeding, bone fracture, kidney failure, decrease or absence of urine, electrolyte disturbances, defective sperm formation, menstruation disorders.
Romanian: Rare (pot afecta până la 1 persoană din 1000): inflamație a sacului din jurul inimii, acumulare de lichid în sacul din jurul inimii, tulburări severe de vedere, fluctuații ale dispoziției, tensiune arterială scăzută, cheaguri de sânge, dureri în gât, respirație înteruptă, astm bronșic, inflamație la nivelul aparatului digestiv, scaune cu sânge, inflamație a gingiilor, digestie anormală, hepatită acută (inflamația ficatului), modificare a culorii unghiilor, acnee, pete roșii sau violet din cauza spargerii unor vase de sânge, fracturi osoase, insuficiență renală, scădere a sau absență a urinatului, tulburări electrolitice, afectare a formării spermei, tulburări menstruale.
English: Nordimet 25 mg solution for injection in pre-filled pen Each pre-filled pen contains 25 mg methotrexate in 1.0 mL
Romanian: Nordimet 25 mg soluţie injectabilă în stilou injector (pen) preumplut Fiecare stilou injector preumplut cu 1,0 ml soluție conține metotrexat 25 mg.
English: EU/1/16/1124/035 - 4 pack
Romanian: EU/1/16/1124/035 - 4 cutii
English: How to give yourself an injection of Nordimet If you have difficulty handling the syringe, ask your doctor or pharmacist.
Romanian: Adresați-vă medicului dumneavoastră sau farmacistului dacă aveți dificultăți în manipularea stiloului injector.
English: Nordimet 17.5 mg solution for injection in pre-filled pen Each pre-filled pen contains 17.5 mg methotrexate in 0.7 mL
Romanian: Nordimet 17,5 mg soluţie injectabilă în stilou injector (pen) preumplut Fiecare stilou injector preumplut cu 0,7 ml soluție conține metotrexat 17,5 mg.
English: Reduced blood cell formation with decrease in white and/or red blood cells and/or platelets (leukopenia, anaemia, thrombocytopenia), headache, tiredness, drowsiness, inflammation of the lungs (pneumonia) with dry, non-productive cough, shortness of breath and fever, diarrhoea, rash, reddening of the skin, itching.
Romanian: scădere a formării de celule ale sângelui, cu scădere a numărului de globule albe și/sau roșii și/sau de plachete sanguine (leucopenie, anemie, trombocitopenie), durere de cap, oboseală, somnolență,
English: EU/1/16/1124/009 - 4 pack (4 packs of 1) EU/1/16/1124/010 - 6 pack
Romanian: EU/1/16/1124/009 - 4 cutii (4 cutii a 1) EU/1/16/1124/010 - 6 cutii
English: Nordimet 12.5 mg solution for injection in pre-filled pen Each pre-filled pen contains 12.5 mg methotrexate in 0.5 mL
Romanian: Nordimet 12,5 mg soluţie injectabilă în stilou injector (pen) preumplu, Fiecare stilou injector preumplut cu 0,5 ml soluție conține metotrexat 12,5 mg.
English: EU/1/16/1124/029 - 4 pack
Romanian: EU/1/16/1124/029 - 4 cutii
English: Nordimet 20 mg solution for injection in pre-filled syringe Each pre-filled syringe contains 20 mg methotrexate in 0.8 mL
Romanian: Nordimet 20 mg soluţie injectabilă în seringă preumplută Fiecare seringă preumplută cu 0,8 ml soluție conține metotrexat 20 mg.
English: EU/1/16/1124/048 - 6 pack
Romanian: EU/1/16/1124/048 - 6 cutii
English: EU/1/16/1124/047 - 4 pack
Romanian: EU/1/16/1124/047 - 4 cutii
English: BSA), methotrexate has a mean bioavailability of approximately 70%, although considerable inter- and intra-subject variations are possible (25-100%).
Romanian: În cazul administrării în doză mică (doze cuprinse între 7,5 mg pe m şi 80 mg pe m suprafaţă corporală), valoarea medie a biodisponibilităţii este de aproximativ 70%, dar sunt posibile variaţii interindividuale şi intra-individuale semnificative (25-100%).
English: EU/1/16/1124/045 - 6 pack
Romanian: EU/1/16/1124/045 - 6 cutii
English: Delayed methotrexate clearance should be considered in combination with other cytostatic medicinal products.
Romanian: Clearance-ul întârziat al metotrexatului poate apărea în cazul asocierii acestuia cu ale medicamente citostatice.
English: One pre-filled pen of 0.9 ml contains 22.5 mg methotrexate (25mg/ml)
Romanian: Un stilou injector (pen) preumplut cu 0,9 ml soluție conține metotrexat 22,5 mg (25 mg/ml)
English: Nordimet 10 mg solution for injection in pre-filled pen Each pre-filled pen contains 10 mg methotrexate in 0.4 mL
Romanian: Nordimet 10 mg soluţie injectabilă în stilou injector (pen) preumplut Fiecare stilou injector preumplut cu 0,4 ml soluție conține metotrexat 10 mg.
English: Nordimet 22.5 mg solution for injection in pre-filled pen EU/1/16/1124/007 - 1 pack
Romanian: Nordimet 22,5 mg soluţie injectabilă în stilou injector (pen) preumplut EU/1/16/1124/007 - 1 cutie
English: If you get any side effects, talk to your doctor or pharmacist.
Romanian: Dacă manifestaţi orice reacţii adverse, adresaţi-vă medicului dumneavoastră sau farmacistului.
English: 5) While holding the body of the pen, pull the cap off. Once you have taken the cap off, keep the pen in your hand.
Romanian: 5) În timp ce cu o mână țineți corpul stiloului injector, trageți capacul cu cealaltă mână.
English: One pre-filled pen of 0.8 ml contains 20 mg methotrexate (25mg/ml)
Romanian: Un stilou injector (pen) preumplut cu 0,8 ml soluție conține metotrexat 20 mg (25 mg/ml)
English: EU/1/16/1124/038 - 4 pack
Romanian: EU/1/16/1124/038 - 4 cutii
English: Nordimet 22.5 mg solution for injection in pre-filled syringe EU/1/16/1124/043 - 1 pack
Romanian: Nordimet 22,5 mg soluţie injectabilă în seringă preumplută EU/1/16/1124/043 - 1 cutie
English: EU/1/16/1124/032 - 4 pack
Romanian: EU/1/16/1124/032 - 4 cutii
English: The doctor will calculate the dose required from the child's body surface area (m2), and the dose is expressed as mg/m
Romanian: Doza la copii și adolescenți sub 16 ani cu formă poliartritică de artrită juvenilă idiopatică Medicul va calcula doza necesară în funcție de suprafața corpului (m2) copilului, iar doza va fi exprimată în mg/m2.
English: EU/1/16/1124/057 - 4 pack (1 pack of 4) EU/1/16/1124/058 - 12 pack
Romanian: EU/1/16/1124/057 - 4 cutii (1 cutie a 4) EU/1/16/1124/058 - 12 cutii
English: Nordimet 7.5 mg solution for injection in pre-filled pen Each pre-filled pen contains 7.5 mg methotrexate in 0.3 mL
Romanian: Nordimet 7,5 mg soluţie injectabilă în stilou injector (pen) preumplut Fiecare stilou injector preumplut cu 0,3 ml soluție conține metotrexat 7,5 mg.
English: One pre-filled pen of 1.0 ml contains 25 mg methotrexate (25mg/ml)
Romanian: Un stilou injector (pen) preumplut cu 1,0 ml soluție conține metotrexat 25 mg (25 mg/ml)
English: If use of methotrexate during the breast-feeding period should become necessary, breast-feeding is to be stopped prior to treatment.
Romanian: Prin urmare, dacă este necesară administrarea metotrexatului în timpul alăptării, se va întrerupe alăptarea înainte de administrarea medicamentului.