FrancophonIA/ELRC3.0 huggingface dataset:
English: ALPROLIX 500 IU powder and solvent for solution for injection ALPROLIX 1000 IU powder and solvent for solution for injection ALPROLIX 2000 IU powder and solvent for solution for injection ALPROLIX 3000 IU powder and solvent for solution for injection eftrenonacog alfa recombinant coagulation factor IX, Fc fusion protein This medicine is subject to additional monitoring.
Croatian: ALPROLIX 500 IU prašak i otapalo za otopinu za injekciju ALPROLIX 1000 IU prašak i otapalo za otopinu za injekciju ALPROLIX 2000 IU prašak i otapalo za otopinu za injekciju ALPROLIX 3000 IU prašak i otapalo za otopinu za injekciju eftrenonakog alfa (eftrenonacog alfa) (fuzijski protein rekombinantnog faktora zgrušavanja krvi IX i Fc fragmenta)
English: After reconstitution, each mL of solution for injection contains approximately 50 IU eftrenonacog alfa.
Croatian: Nakon rekonstitucije, svaki ml otopine za injekciju sadrži približno 50 IU eftrenonakoga alfa.
English: Solvent: sodium chloride, water for injections
Croatian: Otapalo: natrijev klorid voda za injekcije
English: After reconstitution, each mL of solution for injection contains approximately 600 IU eftrenonacog alfa.
Croatian: Nakon rekonstitucije, svaki ml otopine za injekciju sadrži približno 600 IU eftrenonakoga alfa.
English: After reconstitution, each mL of solution for injection contains approximately 400 IU eftrenonacog alfa.
Croatian: Nakon rekonstitucije, svaki ml otopine za injekciju sadrži približno 400 IU eftrenonakoga alfa.
English: After reconstitution, each mL of solution for injection contains approximately 100 IU eftrenonacog alfa.
Croatian: Nakon rekonstitucije, svaki ml otopine za injekciju sadrži približno 100 IU eftrenonakoga alfa.
English: After reconstitution, each mL of solution for injection contains approximately 200 IU eftrenonacog alfa.
Croatian: Nakon rekonstitucije, svaki ml otopine za injekciju sadrži približno 200 IU eftrenonakoga alfa.
English: You should always use ALPROLIX exactly as your doctor has told you, check with your doctor, pharmacist or nurse if you are not sure.
Croatian: Uvijek primijenite ALPROLIX točno onako kako Vam je rekao Vaš liječnik.
English: Each pack contains: - powder in a type 1 glass vial with a chlorobutyl rubber stopper - 5 mL solvent in a type 1 glass pre-filled syringe with a bromobutyl rubber plunger stopper - a plunger rod - a sterile vial adapter for reconstitution - a sterile infusion set - alcohol swab(s) - plaster(s) - gauze pad(s).
Croatian: - 5 ml otapala u napunjenoj štrcaljki od stakla tipa 1 s čepom klipa od brombutilne gume - klip
English: Mannitol
Croatian: ALPROLIX.
English: 12 to <18 years
Croatian: 18 godina.
English: Paresthesia oral Breath odour
Croatian: Izraženija hemartroza,
English: Attach the syringe with the prepared ALPROLIX solution to the end of the infusion set tubing by turning clockwise.
Croatian: ALPROLIX na kraj cijevi kompleta za infuziju tako što ćete je zakrenuti u smjeru kazaljke na satu.
English: Previously untreated patients
Croatian: Iskustvo u bolesnika u dobi
English: … or onto a small amount of food.
Croatian: … ili na malu količinu hrane.
English: No significant gender effect was seen.
Croatian: Nije utvrđen značajan učinak spola.
English: The product is to be administered once daily directly into the mouth or with a small amount of food.
Croatian: Proizvod treba primjenjivati jedanput na dan, izravno u usta ili s malom količinom hrane.
English: Wash hands after use.
Croatian: Operite ruke poslije primjene.
English: EXP {month/year} Once opened use by ....
Croatian: EXP {mjesec/godina} Jednom otvoren upotrijebiti do…
English: The terminal elimination half-life (t1/2) ranged from 7.3 hours to 8.6 hours, with mean value 7.7 hours.
Croatian: Terminalni poluvijek eliminacije (t1/2) kretao se u rasponu od 7,3 sata do 8,6 sati, uz prosječnu vrijednost od 7,7 sati.
English: ATCvet code: QC09CA07
Croatian: ATCvet kod: QC09CA07
English: EXP {month/year} Once opened use within 6 months.
Croatian: EXP {mjesec/godina} Jednom otvoren upotrijebiti u roku od 6 mjeseci.
English: See section “Contraindications”.
Croatian: Vidjeti dio „Kontraindikacije“.
English: Elevated liver enzymes have been very rarely observed and values normalised within a few days following cessation of therapy.
Croatian: Povišeni jetreni enzimi primijećeni su vrlo rijetko, a vrijednosti su se normalizirale u roku od nekoliko dana po prestanku terapije.
English: In case of accidental eye contact, rinse eyes with water.
Croatian: U slučaju nehotičnog doticaja s očima, oči isperite vodom.
English: Semintra is an oral solution and is well accepted by most cats.
Croatian: Semintra je otopina za peroralnu primjenu i većina je mačaka dobro prihvaća.
English: The absolute bioavailability after oral administration was found to be 33%.
Croatian: Apsolutna bioraspoloživost nakon peroralne primjene iznosila je 33%.
English: Treatment of systemic hypertension in cats.
Croatian: Liječenje sustavne hipertenzije u mačaka.
English: The CVMP agreed that the periodic safety update report (PSUR) cycle would be re-started at 6 months, 12 months and 24 months following authorisation of the extension, as detailed in the CVMP assessment report.
Croatian: Odbor za veterinarsko-medicinske proizvode (CVMP) odlučio je da će ciklus dostave periodičkih izvješća o neškodljivosti (PSUR) ponovno početi 6 mjeseci, 12 mjeseci i 24 mjeseca nakon produljenja odobrenja, kako je opisano u izvješću o procjeni CVMP-a.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the carton and the bottle after EXP.
Croatian: Ne koristite veterinarsko-medicinski proizvod poslije isteka roka valjanosti naznačenog na kutiji i bočici poslije EXP.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reactions) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Croatian: Učestalost nuspojava je određena sukladno sljedećim pravilima: - vrlo česte (više od 1 na 10 tretiranih životinja pokazuju nuspojave) - česte (više od 1 ali manje od 10 životinja na 100 tretiranih životinja) - manje česte (više od 1 ali manje od 10 životinja na 1.000 tretiranih životinja) - rijetke (više od 1 ali manje od 10 životinja na 10.000 tretiranih životinja) - vrlo rijetke (manje od 1 životinje na 10.000 tretiranih životinja, uključujući izolirane slučajeve).
English: Shelf life of the veterinary medicinal product as packaged for sale (30 ml or 100 ml): 3 years.
Croatian: Rok valjanosti veterinarsko-medicinskog proizvoda kad je zapakiran za prodaju (30 ml ili 100 ml): 3 godine.
English: See section “Pregnancy and lactation”.
Croatian: Vidjeti dio „Graviditet i laktacija“.
English: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Croatian: Bilo koji neupotrijebljeni veterinarsko-medicinski proizvod ili otpadni materijali dobiveni primjenom tih veterinarsko-medicinskih proizvoda trebaju se odlagati u skladu s lokalnim propisima.
English: Do not use during pregnancy or lactation (see also section 4.7).
Croatian: Ne primjenjivati za vrijeme graviditeta ili laktacije (vidjeti također dio 4.7).
English: Separate the dosing syringe from the bottle.
Croatian: Odvojite štrcaljku za doziranje od bočice.
English: It is good clinical practice to monitor the blood pressure of cats receiving Semintra which are under anaesthesia.
Croatian: Dobra je klinička praksa nadzirati krvni tlak u mačaka koje primaju proizvod Semintra kad su pod anestezijom.
English: When using this product in cats with severe kidney disease, it is advisable to monitor renal function (plasma creatinine concentration).
Croatian: Pri primjeni ovog proizvoda u mačaka s teškom bubrežnom bolešću preporučuje se nadzirati bubrežnu funkciju (koncentracija kreatinina u plazmi).
English: The safety and efficacy of telmisartan for the management of systemic hypertension above 200 mmHg has not been investigated.
Croatian: Neškodljivost i djelotvornost telmisartana za regulaciju sustavne hipertenzije više od 200 mmHg nisu ispitane.
English: The safety and efficacy of telmisartan in such patients has not been investigated.
Croatian: Neškodljivost i djelotvornost telmisartana u takvih pacijenata još nisu ispitane.
English: Telmisartan is highly lipophilic and has rapid membrane permeability kinetics, which facilitates easy distribution into tissue.
Croatian: Telmisartan je visoko lipofilan i ima brzu kinetiku permeabilnosti membrane što olakšava raspodjelu u tkivo.
English: After oral administration, telmisartan is almost exclusively excreted in the faeces mainly as the unchanged active substance.
Croatian: Nakon peroralne primjene telmisartan se gotovo isključivo izlučuje u stolici, uglavnom kao nepromijenjena djelatna tvar.
English: The safety and efficacy of telmisartan has not been tested in cats under the age of 6 months.
Croatian: Neškodljivost i djelotvornost telmisartana nisu ispitane u mačaka mlađih od 6 mjeseci.
English: Telmisartan selectively binds to the AT1 receptor and does not show affinity for other receptors, including AT2 or other less characterised AT receptors.
Croatian: Telmisartan se selektivno veže na receptore AT1 i ne pokazuje afinitet prema drugim receptorima, uključujući AT2 ili druge manje karakterizirane receptore za AT.
English: Clear, colourless to yellowish viscous solution.
Croatian: Bistra, bezbojna do žućkasta viskozna otopina.
English: The glucuronidation resulted in the formation of the 1-O-acylglucuronide metabolite of telmisartan.
Croatian: Glukuronidacija je rezultirala stvaranjem metabolita telmisartana 1-O-acilglukuronida.
English: Turn the bottle/syringe upside down.
Croatian: Okrenite bočicu/štrcaljku prema dolje.
English: To avoid contamination, use the provided syringe only to administer Semintra.
Croatian: Da bi se izbjegla kontaminacija, priloženu štrcaljku upotrijebite samo za primjenu Semintre.
English: One ml contains: Telmisartan
Croatian: Jedan ml sadrži: telmisartan
English: Do not use during pregnancy and lactation (see section 4.3).
Croatian: Ne primjenjivati za vrijeme graviditeta i laktacije (vidjeti dio 4.3).
English: The safety of Semintra has not been established in breeding, pregnant or lactating cats.
Croatian: Neškodljivost proizvoda Semintra nije utvrđena u mačaka za vrijeme parenja, graviditeta ili laktacije.
English: Avoid eye contact.
Croatian: Izbjegavati da dođe u doticaj s očima.
English: People with hypersensitivity to telmisartan or other sartans/ARBs should avoid contact with the veterinary medicinal product.
Croatian: Osobe preosjetljive na telmisartan ili druge sartane/blokatore angiotenzinskih receptora moraju izbjegavati doticaj s ovim veterinarsko-medicinskim proizvodom.
English: If the SBP increases over the course of the disease the daily dose may be increased again up to 2 mg/kg.
Croatian: Ako se sistolički krvni tlak poveća u tijeku bolesti, dnevna doza može se ponovno povećati do 2 mg/kg.
English: The combination of telmisartan with such agents may lead to additive hypotensive effects or may alter renal function.
Croatian: Kombinacija telmisartana i takvih tvari može dovesti do aditivnog hipotenzivnog učinka ili može utjecati na bubrežnu funkciju.
English: For both, Cmax-values, and AUC-values, a dose proportional increase over the dose range from 0.5 mg/kg to 3 mg/kg was observed.
Croatian: Za obje vrijednosti; Cmax i površinu ispod krivulje, opaženo je povećanje proporcionalno dozi iznad raspona doza od 0,5 mg do 3 mg/kg.
English: In vitro studies in human, dog, mouse and rat plasma showed a high plasma protein binding (>99.5%), mainly to albumin and α-1-acid glycoprotein.
Croatian: In vitro ispitivanja u plazmi čovjeka, psa, miša i štakora pokazala su visoko vezanje na proteine u plazmi (> 99,5%) uglavnom na albumin i α-1 kiseli glikoprotein.
English: No pharmacological activity has been shown for the conjugate.
Croatian: Za konjugat se nije pokazala Farmakološka aktivnost konjugata nije dokazana.
English: Due to the mode of action of the veterinary medicinal product, transient hypotension (low blood pressure) may occur.
Croatian: Zbog načina djelovanja veterinarsko-medicinskog proizvoda može se pojaviti prolazna hipotenzija (niski krvni tlak).
English: Push the plunger to empty the contents of the syringe directly into the mouth of the cat
Croatian: Gurnite klip i istisnite sadržaj štrcaljke izravno u usta mačke...
English: Due to the combination of these pharmacodynamic properties, telmisartan is an appropriate treatment for cats with concomitant hypertension and CKD.
Croatian: Zbog kombinacije tih farmakodinamičkih svojstava telmisartan je prikladan za liječenje mačaka s istodobnom hipertenzijom i kroničnom bubrežnom bolešću.
English: The following mild and transient gastrointestinal signs have rarely been observed in a clinical study (in order of decreasing frequency): mild and intermittent regurgitation, vomiting, diarrhoea or soft faeces.
Croatian: U kliničkom ispitivanju rijetko su opaženi sljedeći blagi i prolazni gastrointestinalni znakovi (redoslijed prema sve rjeđoj pojavnosti): blaga i intermitentna regurgitacija, povraćanje, proljev ili mekani izmet.
English: The receptor binding is long lasting due to the slow dissociation of telmisartan from the AT1 receptor binding site.
Croatian: Vezanje za receptor dugotrajno je zbog spore razgradnje telmisartana s mjesta vezanja za receptor AT1.
English: As known from substances acting on the Renin-Angiotensin-Aldosterone System (RAAS), a slight decrease in red blood cell count may occur.
Croatian: Kao tvar za koju se zna da djeluje na sustav renina-angiotenzina-aldosterona (RAAS), može se pojaviti neznatno smanjenje broja crvenih krvnih stanica.
English: Due to the mode of action of the veterinary medicinal product, transient hypotension may occur.
Croatian: Zbog načina djelovanja veterinarsko-medicinskog proizvoda može se pojaviti prolazna hipotenzija.
English: In a European clinical field study, adverse events categorised as renal disorder/insufficiency (includes cases of chronic renal failure, elevated creatinine and/or blood urea nitrogen) were recorded in 3.6% of telmisartan-treated cats and 1% of placebo-treated cats.
Croatian: U europskom kliničkom terenskom ispitivanju nuspojave kategorizirane kao bubrežni poremećaj / bubrežna insuficijencija (uključuje slučajeve kroničnog zatajenja bubrega, povišenog kreatinina i/ili urea nitrata u krvi) zabilježene su u 3,6 % mačaka tretiranih telmisartanom i 1 % mačaka tretiranih placebom.
English: The dosage of telmisartan should be reduced if systolic blood pressure (SBP) is consistently lower than 120 mmHg or if there are concurrent signs of hypotension.
Croatian: Dozu telmisartana treba smanjiti ako je sistolički krvni tlak (SKT) konzistentno niži od 120 mmHg ili ako istodobno postoje klinički znakovi hipotenzije.
English: The dosing regimen for hypertensive cats with concomitant chronic kidney disease is as described above except that for these cats the recommended minimum effective dose is 1 mg/kg.
Croatian: U mačaka s hipertenzijom i istodobnom kroničnom bubrežnom bolešću način doziranja jednak je prethodno opisanom, ali za te mačke preporučena minimalna djelotvorna doza iznosi 1 mg/kg.
English: From in vitro and ex vivo studies with feline liver microsomes it can be concluded that telmisartan is effectively glucuronidated in the cat.
Croatian: Na temelju in vitro i ex vivo ispitivanja s mačjim mikrosomima jetre, može se zaključiti da se telmisartan u mačaka djelotvorno glukuronizira.
English: After 4 weeks, the dosage of telmisartan may be reduced in cats with systolic blood pressure (SBP) of less than 140 mmHg (in 0.5 mg/kg increments) at the discretion of the veterinarian.
Croatian: Nakon 4 tjedna, doza telmisartana može se smanjiti u mačaka sa sistoličkim krvnim tlakom nižim od 140 mmHg (u koracima od 0,5 mg/kg) prema odluci veterinara.
English: Red blood cell count should be monitored during therapy.
Croatian: Tijekom terapije treba pratiti broj crvenih krvnih stanica.
English: Telmisartan does not exhibit any partial agonist activity at the AT1 receptor.
Croatian: Telmisartan ne pokazuje parcijalni agonistički učinak na receptoru AT1.
English: Boehringer Ingelheim Vetmedica GmbH 55216 Ingelheim/Rhein GERMANY
Croatian: Boehringer Ingelheim Vetmedica GmbH 55216 Ingelheim/Rhein Njemačka
English: No clinically relevant accumulation was observed following multiple dose administration once daily for 21 days.
Croatian: Nakon primjene višestruke doze jedanput na dan tijekom 21 dana nije opažena klinički relevantna akumulacija.
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system, angiotensin II antagonists, plain.
Croatian: Farmakoterapijska skupina: tvari koje djeluju na sustav renin-angiotenzin, antagonisti angiotenzina II, jednokomponentni proizvodi.
English: After administration of the veterinary medicinal product, close the bottle tightly with the cap, wash the measuring syringe with water and let it dry.
Croatian: Poslije primjene veterinarsko-medicinskog proizvoda čvrsto zatvorite bočicu zatvaračem, mjernu štrcaljku operite s vodom i pustite da se osuši.
English: Pull the plunger out until the end of the plunger corresponds to the amount needed in ml.
Croatian: Izvlačite klip štrcaljke sve dok kraj klipa ne dosegne oznaku potrebne količine u mililitrima.
English: Pull the plunger out until the end of the plunger corresponds to your cat´s body weight in kilograms.
Croatian: Izvlačite klip štrcaljke sve dok kraj klipa ne dosegne oznaku u kilogramima koja odgovara težini Vaše mačke.
English: 5.2 Pharmacokinetic properties
Croatian: 5.2 Farmakokinetički podaci
English: Pregnant women should take special care to avoid contact with the product because substances acting on the RAAS, such as Angiotensin Receptor Blockers (ARBs) and ACE inhibitors (ACEis), have been found to affect the unborn child during pregnancy in humans.
Croatian: Trudnice moraju osobito paziti da izbjegavaju doticaj s ovim proizvodom jer je ustanovljeno da tvari koje djeluju na sustav renin-angiotenzin-aldosteron, kao što su blokatori angiotenzinskih receptora (ARB) i inhibitori acetilkolinesteraze (ACEi), utječu na nerođeno dijete tijekom trudnoće u ljudi.
English: 35 ml 1 measuring syringe
Croatian: 35 ml 1 mjerna štrcaljka
English: Excipients: Benzalkonium chloride 0.1 mg
Croatian: Pomoćna tvar: Benzalkonijev klorid 0,1 mg
English: Benzalkonium chloride Hydroxyethylcellulose Sodium hydroxide (for pH adjustment) Hydrochloric acid (for pH adjustment) Maltitol
Croatian: 6.1 Popis pomoćnih tvari benzalkonijev klorid hidroksietilceluloza natrijev hidroksid (za podešavanje pH) kloridna kiselina (za podešavanje pH) maltitol pročišćena voda
English: Shelf life after first opening of the bottle: 6 months.
Croatian: Rok valjanosti poslije prvog otvaranja spremnika: 6 mjeseci.
English: In a clinical trial in cats with chronic kidney disease, a reduction in proteinuria was seen within the first 7 days after the start of treatment.
Croatian: U kliničkom ispitivanju provedenom u mačaka s kroničnom bubrežnom bolešću, smanjenje proteinurije ustanovljeno je u prvih 7 dana nakon početka liječenja.
English: One HDPE bottle filled with 30 ml or 100 ml.
Croatian: Jedna HDPE bočica sadržaja sa 30 ml ili 100 ml.
English: The initial recommended dose is 2 mg telmisartan/kg body weight (0.2 ml/kg body weight).
Croatian: Početna preporučena doza iznosi 2 mg telmisartana po kilogramu tjelesne mase (0,2 ml/kg tjelesne mase).
English: Telmisartan displaces angiotensin II from its binding site at the AT1 receptor subtype.
Croatian: Telmisartan izmješta angiotenzin II s njegova mjesta vezanja na receptoru podtipa AT1.
English: Reduction of proteinuria associated with chronic kidney disease (CKD) in cats.
Croatian: Smanjenje proteinurije povezane s kroničnom bubrežnom bolešću u mačaka.
English: Stimulation of the AT1 receptor is responsible for pathologic effects of angiotensin II in the kidney and other organs associated with angiotensin II such as vasoconstriction, retention of sodium and water, increased aldosterone synthesis, organ remodelling and proteinuria.
Croatian: Stimulacija receptora AT1 odgovorna je za patološke učinke angiotenzina II u bubregu i drugim organima povezanim s angiotenzinom II kao što su vazokonstrikcija, retencija natrija i vode, povećana sinteza aldosterona, remodeliranje organa i proteinurija.
English: Effects associated with stimulation of the AT2 receptor such as vasodilatation, natriuresis and inhibition of inappropriate cell growth are not suppressed.
Croatian: Učinci povezani sa stimulacijom receptora AT2 kao što je vazodilatacija, natriureza i inhibicija neodgovarajućeg rasta stanica nisu suprimirane.
English: Telmisartan is metabolised by conjugation to the glucuronide of the parent compound.
Croatian: Telmisartan se metabolizira konjugacijom u glukuronid početnog spoja.
English: The recommended dose is 1 mg telmisartan/kg body weight (0.25 ml/kg body weight).
Croatian: Preporučena doza iznosi 1 mg telmisartana po kilogramu tjelesne mase (0,25 ml/kg tjelesne mase).
English: Effects attributable to the pharmacological activity of the product observed at the recommended treatment dose included reductions in blood pressure and decreases in red blood cell counts.
Croatian: Učinci koji se mogu pripisati farmakološkoj aktivnosti proizvoda, a opaženi su uz preporučenu terapijsku dozu, uključivali su sniženje krvnog tlaka i smanjenje broja crvenih krvnih stanica.
English: Following oral administration of telmisartan to cats, plasma-concentration-time curves of the parent compound are characterised by rapid absorption, with maximum plasma concentrations (Cmax) achieved after 0.5 hours (tmax).
Croatian: Nakon peroralne primjene telmisartana u mačaka krivulje plazmatske koncentracije osnovnog spoja u odnosu na vrijeme obilježava brza apsorpcija uz maksimalnu koncentraciju u plazmi (Cmax) postignutu nakon 0,5 sati (tmax).
English: Telmisartan is an orally active and specific angiotensin II receptor (subtype AT1) antagonist which causes a dose-dependent decrease in mean arterial blood pressure in mammalian species including the cat.
Croatian: Telmisartan je u peroralnoj primjeni aktivan i specifičan antagonist receptora angiotenzina II (podtip AT1) koji uzrokuje o dozi ovisno smanjenje prosječnog arterijskog krvnog tlaka sisavaca, uključujući mačku.
English: In a clinical trial in cats with chronic kidney disease, a reduction in proteinuria was seen within the first 7 days after the start of treatment with 1 mg/kg.
Croatian: U kliničkom ispitivanju provedenom u mačaka s kroničnom bubrežnom bolešću, smanjenje proteinurije ustanovljeno je u prvih 7 dana nakon početka liječenja dozom od 1 mg/kg.
English: Marketing authorisation holder and manufacturer responsible for batch release Boehringer Ingelheim Vetmedica GmbH 55216 Ingelheim/Rhein
Croatian: Naziv i adresa proizvođača odgovornog za puštanje serije u promet Boehringer Ingelheim Vetmedica GmbH 55216 Ingelheim/Rhein
English: Stimulation of the AT1 receptor is responsible for pathologic effects of angiotensin II in the kidney and other organs associated with angiotensin II such as vasoconstriction, retention of sodium and water, increased aldosterone synthesis and organ remodelling.
Croatian: Stimulacija receptora AT1 odgovorna je za patološke učinke angiotenzina II u bubregu i drugim organima povezanim s angiotenzinom II kao što su vazokonstrikcija, retencija natrija i vode, povećana sinteza aldosterona i remodeliranje organa.