FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Croatian: U bolesnika koji već boluju od poremećaja jetrene funkcije, uključujući kronični aktivni hepatitis, češće su zabilježene abnormalnosti funkcije jetre tijekom kombiniranog antiretrovirusnog liječenja te takve bolesnike treba pratiti prema uobičajenoj praksi.
English: D. CONDITIONS OR RESTRICTIONSWITH REGARD TO THE SAFE ANDEFFECTIVE USE OF THE MEDICINAL PRODUCT
Croatian: UVJETI ILI OGRANIČENJA VEZANI UZ SIGURNU I UČINKOVITU PRIMJENU LIJEKA
English: Observational studies have shown an association between myocardial infarction and the use of abacavir.
Croatian: Opservacijske studije pokazale su povezanost infarkta miokarda s uporabom abakavira.
English: The tablet coating contains hypromellose, titanium dioxide, polyethylene glycol, indigo carmine aluminium lake, iron oxide yellow.
Croatian: Ovojnica tablete sadrži hipromelozu, titanijev dioksid, polietilenglikol, te boju indigo carmine aluminium lake i žuti željezov oksid.
English: The demonstration of the benefit of Trizivir is mainly based on results of studies performed in treatment naive patients or moderately antiretroviral experienced patients with non-advanced disease.
Croatian: Pokazana korist primjene lijeka Trizivir uglavnom se temelji na rezultatima ispitivanja provedenim na bolesnicima koji ranije nisu primali nikakvu terapiju ili onima s umjerenim iskustvom liječenja antiretrovirusnim lijekovima i bolešću koja nije uznapredovala.
English: In the present case, the use in pregnant women of zidovudine, with subsequent treatment of the newborn infants, has been shown to reduce the rate of maternal-foetal transmission of HIV.
Croatian: U ovom trenutku, upotreba zidovudina kod trudnica te naknadna terapija novorođenčadi pokazala je smanjenu stopu prijenosa HIV-a s majke na fetus.
English: The Trizivir pack includes an Alert Card, to remind you and medical staff about hypersensitivity reactions.
Croatian: Pakiranje lijeka Trizivir sadrži Karticu s upozorenjima, koja služi da Vas i zdravstvene djelatnike podsjeti na reakcije preosjetljivosti.
English: • dapsone, to prevent pneumonia and treat skin infections
Croatian: • dapson, za sprječavanje upale pluća i liječenje kožnih infekcija
English: Zidovudine showed clastogenic effects in oral repeated dose micronucleus tests in mice and rats.
Croatian: Zidovudin je pokazao klastogeni učinak u mikronukleusnom testu na miševima i štakorima pri ponavljanim oralnim dozama.
English: At a therapeutic dose (one Trizivir tablet twice daily) in patients, the mean (CV) steady-state Cmax of abacavir, lamivudine and zidovudine in plasma are 3.49 µg/ml (45 %), 1.33 µg/ml (33 %) and 1.56 µg/ml (83 %), respectively.
Croatian: Pri terapijskim dozama (jedna tableta lijeka Trizivir dva puta na dan) u bolesnika su izmjerene srednje vrijednosti (CV) ravnotežnog Cmax za abakavir, lamivudin i zidovudin u plazmi bile, prema redoslijedu navođenja, 3,49 µg/ml (45%), 1,33 µg/ml (33%) i 1,56 µg/ml (83%).
English: If you forget to take Trizivir
Croatian: Ako ste zaboravili uzeti Trizivir
English: If you have discontinued Trizivir due to this reaction, YOU MUST NEVER TAKE Trizivir, or any medicine containing abacavir (Kivexa, Ziagen or Triumeq) again as within hours you may experience a life-threatening lowering of your blood pressure or death.
Croatian: Ako ste zbog takve reakcije prestali uzimati Trizivir, VIŠE NIKADA NE SMIJETE UZIMATI Trizivir niti druge lijekove koji sadrže abakavir (npr. Kivexa, Ziagen ili Tiumeq) jer unutar nekoliko sati možete razviti po život opasno sniženje krvnog tlaka ili smrt.
English: Carcinogenicity studies with orally administered abacavir in mice and rats showed an increase in the incidence of malignant and non-malignant tumours.
Croatian: Ispitivanja karcinogenosti peroralno primijenjenog abakavira u miševa i štakora pokazala su porast incidencije malignih i nemalignih tumora.
English: The other ingredients are microcrystalline cellulose, sodium starch glycollate and magnesium stearate in the core of the tablet.
Croatian: Pomoćne tvari su mikrokristalična celuloza, natrijev škroboglikolat i magnezijev stearat u jezgri tablete.
English: They are listed by body system, organ class and absolute frequency.
Croatian: Nuspojave su navedene prema klasifikaciji po organskim sustavima i apsolutnoj učestalosti.
English: • Trizivir must be stopped without delay, even in the absence of the HLA-B*5701 allele, if an HSR is suspected.
Croatian: • Liječenje lijekom Trizivir mora se bez odlaganja prekinuti, čak i u odsustvu alela HLA-B*5701, ako se posumnja na reakciju preosjetljivosti.
English: MISCELLANEOUS Ethanol/Abacavir (0.7 g/kg single dose/600mg single dose)
Croatian: OSTALO etanol/abakavir (0,7 g/kg jednokratna doza/600 mg jednokratna doza)
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Croatian: Zabilježeno je da se autoimuni poremećaji (kao što je Gravesova bolest i autoimuni hepatitis) javljaju kod imune reaktivacije, međutim, zabilježeno vrijeme početka je varijabilno te se ovi događaji mogu javiti mnogo mjeseci nakon početka liječenja (vidjeti dio 4.4).
English: The mean ratios of CSF/serum lamivudine and zidovudine concentrations 2 - 4 hours after oral administration were approximately 0.12 and 0.5 respectively.
Croatian: Srednji omjeri koncentracija lamivudina i zidovudina u SŽS/serumu 2 - 4 sata nakon peroralne primjene iznose oko 0,12 i 0,5, prema redoslijedu navođenja.
English: Abacavir, lamivudine and zidovudine are rapidly and well absorbed from the gastro-intestinal tract following oral administration.
Croatian: Abakavir, lamivudin i zidovudin se brzo i dobro apsorbiraju iz gastrointestinalnog sustava nakon peroralne primjene.
English: Since Trizivir contains abacavir some patients taking Trizivir may develop a hypersensitivity reaction (serious allergic reaction) which can be life-threatening if treatment with Trizivir is continued.
Croatian: Budući da Trizivir sadržava abakavir, neki bolesnici koji uzimaju Trizivir mogu razviti reakciju preosjetljivosti (ozbiljnu alergijsku reakciju) koja može biti opasna po život ako se nastavi s uzimanjem lijeka Trizivir.
English: Most patients experiencing virological failure with a regimen containing abacavir in a pivotal clinical trial with Combivir (fixed dose combination of lamivudine and zidovudine) showed either no NRTI-related changes from baseline (15 %) or only M184V or M184I selection (78 %).
Croatian: Većina bolesnika u kojih je izostao virološki odgovor na liječenje abakavirom iz pivotalnih kliničkih ispitivanja lijeka Combivir (kombinacija fiksne doze lamivudina i zidovudina),pokazali su ili nikakav pomak od početnih vrijednosti povezan s NRTI (15%) ili samo selekciju M184V ili M184I (78 %).
English: Headache, paraesthesia
Croatian: dispepsija, pankreatitis
English: The carcinogenic potential of a combination of abacavir, lamivudine and zidovudine has not been tested.
Croatian: Karcinogeni potencijal kombinacije abakavira, lamivudina i zidovudina nije ispitivan.
English: Zidovudine AUC ↑33% Atovaquone AUC ↔
Croatian: zidovudin AUC ↑33% atovakon AUC ↔
English: Tablet Coating:
Croatian: Ovojnica tablete:
English: Uncommon: rash and pruritus Rare: nail and skin pigmentation, urticaria and sweating
Croatian: Manje često: osip i pruritus Rijetko: pigmentacija kože i noktiju, urtikarija i znojenje
English: Patients should be advised that Trizivir or any other antiretroviral therapy does not cure HIV infection and that they may still develop opportunistic infections and other complications of HIV infection.
Croatian: Bolesnici koji uzimaju Trizivir ili bilo koju drugu antiretrovirusnu terapiju, mogu i dalje razvijati oportunističke infekcije i druge komplikacije HIV infekcije jer ti lijekovi ne liječe HIV infekciju.
English: A moderate amount of data on pregnant women taking the individual actives abacavir, lamivudine and zidovudine in combination indicates no malformative toxicity (more than 300 outcomes from first trimester exposures).
Croatian: Određena količina podataka koja se odnosi na trudnice koje su uzimale abakavir, lamivudin i zidovudin u kombinaciji upućuje da ne postoji malformacijska toksičnost (više od 300 ishoda za izloženost tijekom prvog trimestra).
English: • feeling depressed or anxious, not being able to concentrate, feeling drowsy
Croatian: • osjećaj depresije ili tjeskobe, nemogućnost uspostavljanja koncentracije, osjećaj mamurnosti • probavne tegobe, poremećaj okusa
English: No definitive recommendation on dose reduction is possible in patients with mild hepatic impairment due to substantial variability of abacavir exposure in this patient population.
Croatian: Ne može se dati konačna preporuka za redukciju doze u bolesnika s blagim oštećenjem funkcije jetre zbog znatnih varijacija u izloženosti abakaviru.
English: Other effects may show up in blood tests
Croatian: Ostali učinci koji se mogu pojaviti u krvnim pretragama
English: In patients with early HIV disease haematological adverse reactions are infrequent.
Croatian: U bolesnika koji su u ranoj fazi HIV bolesti hematološke nuspojave su rijetke.
English: The observed values of the peak concentrations are 9 fold greater than the IC50 of abacavir of 0.08 µg/ml or 0.26 µM when abacavir is given at 600 mg twice daily.
Croatian: Opažene vrijednosti vršnih koncentracija su 9 puta veće nego IC50 abakavira od 0,08 µg/ml ili 0,26 µM
English: • numbness or weakness in the limbs
Croatian: • utrnulost ili slabost u udovima.
English: • a decrease in the number of cells involved in blood clotting (thrombocytopenia), or in all kinds of blood cells (pancytopenia)
Croatian: • smanjenje broja trombocita, krvnih pločica važnih za zgrušavanje krvi (trombocitopenija), ili svih vrsta krvnih stanica (pancitopenija).
English: • fluconazole or flucytosine, to treat fungal infections such as candida
Croatian: • flukonazol ili flucitozin, za liječenje gljivičnih infekcija poput kandidijaze
English: No antagonistic effects in vitro were seen with zidovudine and other antiretrovirals (tested agents: didanosine and interferon-alpha).
Croatian: Nisu primijećeni antagonistički učinci in vitro s primjenom zidovudina i ostalih antiretrovirotika (testirani lijekovi: didanozin i interferon alfa).
English: A transplacental genotoxicity study conducted in monkeys compared zidovudine alone with the combination of zidovudine and lamivudine at humanequivalent exposures.
Croatian: U ispitivanjima transplacentarne genotoksičnosti na majmunima uspoređivao se sami zidovudin s kombinacijom zidovudina i lamivudina u dozama ekvivalentnim ljudskima.
English: Although a similar antiviral effect was observed between the abacavir and indinavir containing regimens in terms of proportion of patients with undetectable viral load (≤ 400 copies/ml; intention to treat analysis (ITT), 47 % versus 49 %; as treated analysis (AT), 86 % versus 94 % for abacavir and indinavir combinations respectively), results favoured the indinavir combination, particularly in the subset of patients with high viral load (> 100,000 copies/ml at baseline; ITT, 46 % versus 55 %; AT, 84 % versus 93 % for abacavir and indinavir respectively).
Croatian: Iako je prema udjelu bolesnika s virusnim opterećenjem kojeg se ne može otkriti zamijećen sličan antivirusni učinak režima koji sadrže abakavir i indinavir (≤ 400 kopija/ml; analiza namjere liječenja (ITT), 47% prema 49%; analiza prema terapiji (AT), 86% prema 94% za kombinacije koje prema redoslijedu navođenja sadrže abakavir i indinavir), rezultati su išli u prilog kombinacija koje sadrže indinavir, osobito u podskupini bolesnika s visokim virusnim opterećenjem (> 100 000 kopija/ml na početku terapije; ITT, 46% prema 55%; AT,
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: U bolesnika zaraženih HIV-om s teškim imunološkim deficitom u vrijeme započinjanja kombinirane antiretrovirusne terapije (KART) može nastupiti upalna reakcija na asimptomatske ili rezidualne oportunističke infekcije.
English: Abacavir, lamivudine and zidovudine triphosphates show significantly less affinity for host cell DNA polymerases.
Croatian: lamivudina i zidovudina pokazuju značajno manji afinitet za DNK polimeraze stanica domaćina.
English: How to take Trizivir
Croatian: Kako uzimati Trizivir
English: Screening is also recommended prior to re-initiation of abacavir in patients of unknown HLA-B*5701 status who have previously tolerated abacavir.
Croatian: Probir se preporučuje i prije ponovnog uvođenja abakavira u bolesnika s nepoznatim HLA-B*5701 statusom koji su prethodno dobro podnosili abakavir.
English: A fertility study in the rat has shown that abacavir had no effect on male or female fertility.
Croatian: Ispitivanja o plodnosti u štakora pokazuju da abakavir i lamivudin nisu imali učinaka na plodnost mužjaka ni ženki.
English: EU/1/00/156/004 - child-resistant foil PVC/PCTFE/PVC-Al/Paper Blister pack (60 Tablets)
Croatian: EU/1/00/156/004 - PVC/ PCTFE /PVC-Al/papir blister pakiranje (60 tableta)
English: Therefore, patients should remain under close clinical observation by physicians experienced in the treatment of these associated HIV diseases.
Croatian: Stoga te bolesnike mora pažljivo nadzirati liječnik koji ima iskustva u liječenju bolesti povezanih s
English: Patients with end-stage renal disease.
Croatian: Bolesnici u završnom stadiju bubrežne bolesti.
English: Patients co-infected with hepatitis C and treated with alpha interferon and ribavirin may constitute a special risk.
Croatian: Poseban rizik mogu predstavljati bolesnici zaraženi hepatitisom C koji se liječe alfa interferonom i ribavirinom.
English: The concomitant use of stavudine with zidovudine should be avoided (see section 4.5).
Croatian: Treba izbjegavati istovremenu primjenu stavudina i zidovudina (vidjeti dio 4.5).
English: The Trizivir pack includes an Alert Card, to remind you and medical staff about abacavir hypersensitivity.
Croatian: Pakiranje lijeka Trizivir sadrži i Karticu s upozorenjem kako bi podsjetila Vas i medicinske djelatnike na moguću preosjetljivost na abakavir.
English: If you have stopped taking Trizivir
Croatian: Ako prestanete uzimati Trizivir
English: Lactic acidosis is more likely to develop in people who have liver disease, or in obese (very overweight) people, especially women.
Croatian: Laktacidoza će se prije razviti u bolesnika koji već imaju bolest jetre ili su pretili (sa znatno prekomjernom tjelesnom težinom), posebice žene.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and can occur many months after initiation of treatment.
Croatian: Zabilježeno je da se autoimuni poremećaji (kao što je Gravesova bolest i autoimuni hepatitis) javljaju kod imune reaktivacije, međutim, zabilježeno vrijeme početka je varijabilno te se ovi događaji mogu javiti mnogo mjeseci nakon početka liječenja.
English: Cases of pancreatitis have occurred rarely in patients treated with abacavir, lamivudine and zidovudine.
Croatian: Rijetko su zabilježeni slučajevi pankreatitisa u bolesnika liječenih abakavirom, lamivudinom i zidovudinom.
English: Doctor:.......................…………………………………………… Tel:...................………………………………………… If your doctor is not available, you must urgently seek alternative medical advice (e.g. the emergency unit of the nearest hospital).
Croatian: Ako Vaš liječnik nije dostupan, hitno potražite savjet drugog liječnika (npr. hitni prijem najbliže liječničke ustanove).
English: Overall the available data from observational cohorts and from randomised trials show some inconsistency so can neither confirm nor refute a causal relationship between abacavir treatment and the risk of myocardial infarction.
Croatian: Sveukupni dostupni podaci iz opservacijskih kohorti i randomiziranih ispitivanja uputili su na određenu nedosljednost zbog čega se ne može do kraja isključiti ili povezati razvoj infarkta miokarda s uporabom abakavira.
English: • a flu-like feeling - chills and sweating
Croatian: • osjećaj kao kod gripe - zimica i znojenje
English: Phenytoin AUC ↑↓
Croatian: fenitoin/zidovudin fenitoin AUC ↑↓
English: Abacavir is associated with a risk for hypersensitivity reactions (HSR) (see section4.8) characterised by fever and/or rash with other symptoms indicating multi-organ involvement.
Croatian: Reakcije preosjetljivosti (vidjeti također dio 4.8): Abakavir se povezuje s rizikom od reakcija preosjetljivosti (vidjeti dio 4.8), koje karakteriziraju vrućica i/ili osip praćeni drugim simptomima koji upućuju na zahvaćenost većeg broja organa.
English: From studies with intravenous zidovudine, the mean terminal plasma half-life was 1.1 hours and the mean systemic clearance was 1.6 l/h/kg.
Croatian: U ispitivanjima s intravenski primijenjenim zidovudinom izmjerena srednja vrijednost poluvremena života u plazmi iznosila je 1,1 sat, a prosječni sistemski klirens iznosio je 1,6 l/h/kg.
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Croatian: U bolesnika zaraženih HIV-om, koji u trenutku započinjanja kombinirane antiretrovirusne terapije (KART) imaju teški imunološki deficit, može se razviti upalna reakcija na asimptomatske ili rezidualne oportunističke patogene te izazvati ozbiljna klinička stanja ili pogoršanje simptoma.
English: Logistic regression modelling of the predictive value for genotype (adjusted for baseline plasma HIV-1 RNA [vRNA], CD4+ cell count, number and duration of prior antiretroviral therapies) showed that the presence of 3 or more NRTI resistance-associated mutations was associated with reduced response at Week 4 (p=0.015) or 4 or more mutations at median Week 24 (p≤0.012).
Croatian: broj CD4+ stanica, broj i trajanje prethodnih antiretrovirusnih terapija) pokazao je da je prisustvo 3 ili više mutacija povezanih s rezistencijom na NRTI povezano sa smanjenim odgovorom u 4. tjednu liječenja (p=0,015), a prisustvo 4 ili više mutacija u 24. tjednu (medijan) (p≤0,012).
English: Where discontinuation of therapy with one of the active substances of Trizivir is indicated, or where dose reduction is necessary separate preparations of abacavir, lamivudine and zidovudine are available.
Croatian: U slučajevima kada je indiciran prekid terapije jednom od djelatnih tvari lijeka Trizivir ili je potrebno smanjenje doze, dostupni su odvojeni pripravci abakavira, lamivudina i zidovudina.
English: For patients co-infected with hepatitis who are being treated with a lamivudine containing medicinal product such as Trizivir and subsequently become pregnant, consideration should be given to the possibility of a recurrence of hepatitis on discontinuation of lamivudine.
Croatian: Za bolesnice istodobno zaražene virusom hepatitisa, a koje su liječene lijekovima koji sadrže lamivudin, kao što je Trizivir te koje u međuvremenu zatrudnile, mora se razmotriti mogućnost recidiva hepatitisa prilikom obustave terapije lamivudinom.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant product information for these medicinal products.
Croatian: U slučaju da bolesnik istodobno prima neki antivirusni lijek za liječenje hepatitisa B ili C, treba proučiti sažetke opisa svojstava lijeka i za te lijekove.
English: Anyone taking Trizivir could develop a hypersensitivity reaction to abacavir, which could be life threatening if they continue to take Trizivir.
Croatian: Svatko tko uzima Trizivir može razviti reakciju preosjetljivosti na abakavir koja može ugroziti život bolesnika ako nastavi uzimati Trizivir.
English: Data obtained in patients with moderate to severe hepatic impairment show that lamivudine pharmacokinetics are not significantly affected by hepatic dysfunction.
Croatian: Podaci dobiveni u bolesnika s umjerenim i teškim oštećenjem funkcije jetre pokazuju da oštećenje jetrene funkcije ne utječe značajno na farmakokinetiku lamivudina.
English: • high doses of co-trimoxazole, an antibiotic
Croatian: • visoke doze kotrimoksazola, antibiotika.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/00/156/003
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/00/156/003
English: Musculoskeletal and connective tissue disorders Common: arthralgia, muscle disorders
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva Često: artralgija, mišićni poremećaji
English: • if you have severe kidney problems
Croatian: • ako imate tešku bolest bubrega
English: Whilst no dose adjustment of abacavir is necessary in patients with renal dysfunction, lamivudine and zidovudine concentrations are increased in patients with renal impairment due to decreased clearance.
Croatian: Iako nije potrebno prilagođavati dozu abakavira u bolesnika s poremećajem funkcije bubrega, u bolesnika s oštećenjem bubrežne funkcije povećane su koncentracije lamivudina i zidovudina zbog smanjenog klirensa.
English: Abacavir is also excreted into human milk.
Croatian: Abakavir se izlučuje i u majčino mlijeko u ljudi.
English: The metabolites and unchanged abacavir account for about 83 % of the administered abacavir dose in the urine the remainder is eliminated in the faeces.
Croatian: Metaboliti i nepromijenjeni abakavir čine oko 83% ukupne primijenjene doze koja se izlučuje urinom.
English: Abacavir HSR has been well characterised through clinical studies and during post marketing followup.
Croatian: Reakcije preosjetljivosti na abakavir temeljito su okarakterizirane tijekom kliničkih ispitivanja i praćenja nakon stavljanja lijeka u promet.
English: Trizivir can make you dizzy and have other side effects that make you less alert.
Croatian: Od lijeka Trizivir možete osjećati vrtoglavicu ili neku drugu nuspojavu zbog koje možete biti manje oprezni.
English: In oral carcinogenicity studies with zidovudine in mice and rats, late appearing vaginal epithelial tumours were observed.
Croatian: U ispitivanjima karcinogenosti peroralne uporabe zidovudina na miševima i štakorima opažena je kasna pojava tumora vaginalnog epitela.
English: Some people who take abacavir may develop a hypersensitivity reaction (a serious allergic reaction), which can be life-threatening if they continue to take abacavir containing products .
Croatian: Neki bolesnici koji uzimaju abakavir mogu razviti reakciju preosjetljivosti (ozbiljnu alergijsku reakciju) koja može biti opasna po život ako se nastavi s uzimanjem lijekova koji sadrže abakavir.
English: Methadone/Abacavir (40 to 90mg once daily for 14 days/600mg single dose, then 600mg twice daily for 14 days)
Croatian: OPIOIDI metadon/abakavir (40 do 90 mg jednom dnevno tijekom 14 dana/600 mg jednokratna doza, zatim 600 mg dva puta na dan tijekom 14 dana)
English: Following multiple oral doses of abacavir 300 mg twice a day there is no significant accumulation of abacavir.
Croatian: 300 mg dva puta na dan nije bilo značajnog nakupljanja lijeka.
English: Pharmacokinetic data has been obtained for abacavir, lamivudine and zidovudine separately.
Croatian: Farmakokinetički podaci su dobiveni odvojeno za abakavir, lamivudin i zidovudin.
English: Trizivir contains abacavir (which is also an active substance in medicines such as Kivexa, Triumeq and Ziagen).
Croatian: Trizivir sadrži abakavir (koji je također djelatna tvar u lijekovima kao što su Kivexa, Triumeq i Ziagen).