FrancophonIA/ELRC3.0 huggingface dataset:
English: There is limited experience in treatment-naïve patients and long-term treatment.
Danish: Der er begrænset erfaring med behandling af patienter, der ikke tidligere har fået botulinumtoksin, og med langtidsbehandling.
English: The applicant is requested to submit the results of all scheduled HDA tests of the upper limb spasticity study (MRZ 0410) and the cervical dystonia study (MRZ 0408) after unblinding of the respective studies.
Danish: Ansøgeren anmodes om at forelægge resultaterne af alle planlagte HDA-test fra undersøgelsen vedrørende spasticitet af overekstremiteterne (MRZ 0410) og fra undersøgelsen vedrørende cervikal dystoni (MRZ 0408), når de pågældende undersøgelser er afblindet.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR MULTI PACK WITH 2, 3, 6 VIALS
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON TIL FLERSTYKSPAKNING MED 2, 3, 6 HÆTTEGLAS
English: Some of the therapeutic and/or side effects of Xeomin may also interfere with the ability to drive and operate machinery.
Danish: Nogle af Xeomins virkninger og bivirkninger kan også påvirke evnen til at føre bil eller betjene maskiner.
English: In 2003, Jankovic compared 130 patients treated for cervical dystonia with original Botox (25ng protein/100 U before 1998), 42 of whom were exposed only to the original Botox and 119 treated with the current Botox (5ng protein/100 U since 1998).
Danish: I 2003 undersøgte Jankovic 130 patienter, der var behandlet for cervikal dystoni med det oprindelige Botox (25 ng protein/100 E før 1998).
English: Of note, the only severe case of dysphagia occurred in a Botox treated patient.
Danish: Det eneste tilfælde af svær dysfagi optrådte hos en patient behandlet med Botox.
English: Due to differences in the LD50 assay, these units are specific to Xeomin and are not applicable to other Botulinum toxin preparations.
Danish: På grund af forskelle i LD50-testen er disse enheder specifikke for Xeomin og kan ikke overføres til andre præparater med botulinumtoksin.
English: very common more than 1 per 10 treated people common less than 1 per 10, but more than 1 per 100 treated people uncommon less than 1 per 100, but more than 1 per 1,000 treated people rare less than 1 per 1,000, but more than 1 per 10,000 treated people very rare less than 1 per 10,000 treated people, incl.
Danish: Mindre almindelig hos færre end 1 ud af 100, men flere end 1 ud af 1.000 behandlede
English: In cases where no therapeutic effect is apparent, alternative therapies should be taken into consideration.
Danish: I tilfælde, hvor behandlingen ikke synes at virke, bør det overvejes at skifte til en anden behandling.
English: A female patient developed brachial plexopathy two days after injection of a conventional preparation containing the Botulinum toxin type A complex for the treatment of cervical dystonia, with recovery after five months.
Danish: En kvindelig patient udviklede plexopathia brachialis to dage efter injektion af et konventionelt præparat med botulinum type A-toksinkompleks til behandling af cervikal dystoni med raskmelding efter fem måneder.
English: The optimum dosage and number of injection sites in the treated muscle will be chosen by your doctor individually for you.
Danish: Den optimale dosering og antallet af injektionssteder i den behandlede muskel fastsættes af lægen specielt for Dem.
English: • aminoglycoside antibiotics
Danish: • antibiotika med aminoglykosid.
English: Various forms of skin eruptions (erythema multiforme, urticaria, psoriasis-like rash), itching, and allergic reactions have been described with the use of conventional preparations containing the Botulinum toxin type A complex, but their causal relationship remains unclear.
Danish: Forskellige former for hududslæt (erythema multiforme, urticaria, psoriasis-lignende udslæt), kløe og allergiske reaktioner er beskrevet ved brug af standardpræparater med botulinum type Atoksinkompleks, men årsagen kendes ikke med sikkerhed.
English: This disease leads to a wasting of muscle tissue.
Danish: Denne sygdom fører til vævshenfald.
English: Uncommon: breathing difficulties (dyspnoea), double vision (diplopia), drooping eyelid (ptosis), voice alteration, fever
Danish: Ikke almindelige: Vejrtrækningsbesvær (dyspnø), dobbeltsyn (diplopi), hængende øjenlåg (ptose), stemmeforandringer, feber
English: Xeomin is indicated for the symptomatic management of blepharospasm and cervical dystonia of a predominantly rotational form (spasmodic torticollis) in adults.
Danish: Xeomin er indiceret til symptombehandling af blefarospame og cervikal dystoni, specielt spastisk torticollis hos voksne.
English: However, there is no indication of a higher antigenic potential of Xeomin compared to Botox.
Danish: Intet tyder imidlertid på, at Xeomin skulle have større antigenvirkning end Botox.
English: generalised weakness, flu like symptoms, malaise Uncommon: fever
Danish: Generel svækkelse, influenzalignende symptomer, utilpashed
English: The treatment of twisted neck may cause swallowing difficulties with varying degrees of severity.
Danish: Behandlingen af ufrivillig halsdrejning kan medføre synkebesvær af forskellig grad.
English: Due to differences in the LD50 assay, these units are specific to Xeomin and are not interchangeable with other Botulinum toxin preparations.
Danish: På grund af forskelle i LD50-testen er disse enheder specifikke for Xeomin og kan ikke erstattes med andre præparater med botulinumtoksin.
English: Resulting dose in units per 0.1 ml
Danish: Dosis efter fortynding (enheder/0,1 ml)
English: The second most frequent (at least possibly related) AE ptosis was reported in a comparable degree (1.9% for Xeomin vs. 1.8% for Botox in the pooled sample and 6.1% for Xeomin vs. 4.6% for Botox in the blepharospasm Phase III study) and occurred in BPS patients only.
Danish: Den næsthyppigste (i det mindste muligvis behandlingsrelaterede) bivirkning var ptose, der optrådte med sammenlignelig hyppighed (henholdsvis 1,9 % for Xeomin og 1,8 % for Botox i den poolede stikprøve, og 6,1% for Xeomin mod 4,6 % for Botox i fase III-blefarospasmeundersøgelsen).
English: Thus, related adverse effects occurred more frequently in the Xeomin group compared to Botox.
Danish: Behandlingsrelaterede bivirkninger optrådte således hyppigere i Xeomin-gruppen end i Botoxgruppen.
English: However, there appears to be no additional benefit obtainable from injecting more than 5.0 U per site.
Danish: Injektion af mere end 5,0 E pr. injektionssted synes imidlertid ikke at indebære yderligere fordele.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR 1 VIAL WHEN THIS IS PART/COMPONENT OF A MULTIPACK WITH 2, 3, 6 VIALS
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON TIL 1 HÆTTEGLAS, NÅR DET ER EN DEL/KOMPONENT AF EN FLERSTYKSPAKNING MED 2, 3, 6 HÆTTEGLAS
English: • if you suffer from any disease that disturbs the interaction between nerves and skeletal muscles
Danish: • hvis De har en sygdom, der forstyrrer interaktionen mellem nerver og skeletmuskulatur (perifer neuromuskulær dysfunktion)
English: Side effects may occur from misplaced injections of Xeomin temporarily paralysing nearby muscle groups.
Danish: Der kan opstå bivirkninger, hvis Xeomin indsprøjtes et forkert sted, med midlertidig lammelse af de nærliggende muskelgrupper.
English: The numbers of adverse events in Phase II study and in Phase III dystonia Study are submitted in the following Table:
Danish: Følgende tabel angiver det oplyste antal bivirkninger i fase II-undersøgelsen og i fase IIIdystoniundersøgelsen:
English: If you have any further questions on the use of this product, ask your doctor or pharmacist.
Danish: Spørg Deres læge eller apotek, hvis De har yderligere spørgsmål om brug af lægemidlet.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR SINGLE UNIT PACK (1 VIAL)
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON TIL ENKELTDOSISPAKNING (1 HÆTTEGLAS)
English: Undesirable effects may occur from misplaced injections of Botulinum neurotoxin type A temporarily paralysing nearby muscle groups.
Danish: Bivirkninger kan opstå på grund af fejlplacerede injektioner af botulinum type A-neurotoksin, der midlertidigt paralyserer nærliggende muskelgrupper.
English: For safe disposal, unused vials should be reconstituted with a small amount of water and then autoclaved.
Danish: For sikker bortskaffelse skal ubrugte hætteglas rekonstitueres med lidt vand og dernæst autoklaveres.
English: • To submit the results of all scheduled HDA tests of the upper limb spasticity study (MRZ 0410) and the cervical dystonia study (MRZ 0408) after unblinding of the respective studies.
Danish: • Forelæggelse af resultaterne af alle planlagte HDA-test i undersøgelsen vedrørende spasticitet af overekstremiteterne (MRZ 0410) og vedrørende cervikal dystoni (MRZ 0408), når de pågældende undersøgelser er afblindet.
English: Side effects related to spread of toxin distant from the site of administration have been reported very rarely (exaggerated muscle weakness, dysphagia, aspiration pneumonitis with fatal outcome in some cases) (see section 4.4).
Danish: Der er rapporteret meget sjældne bivirkninger, der skyldtes spredning af toksinet fjernt fra administrationsstedet (voldsom muskelsvækkelse, dysfagi og aspirationspneumoni med dødeligt udfald i nogle tilfælde) (se pkt.
English: In contrast to conventional preparations containing the Botulinum toxin type A complex, Xeomin contains pure (150 kD) neurotoxin since it is free of complexing proteins.
Danish: Modsat konventionelt fremstillede præparater med botulinum type A-toksinkompleks indeholder Xeomin rent (150 kD) neurotoksin, idet det ikke indeholder kompleksdannende proteiner.
English: It is not known whether Botulinum neurotoxin type A is excreted into the breast milk.
Danish: Det vides ikke, om botulinum type A-neurotoksin udskilles i modermælk, og brug af Xeomin under amningen frarådes.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR 1 VIAL WHEN THIS IS PART/COMPONENT OF A CLINICAL PACK WITH 6 VIALS
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON TIL 1 HÆTTEGLAS, NÅR DET ER EN DEL/KOMPONENT AF EN HOSPITALSPAKNING MED 6 HÆTTEGLAS
English: • if bleeding disorders of any type occur
Danish: • hvis der opstår en blødningsforstyrrelse uanset art
English: Unit doses recommended for Xeomin are not interchangeable with those for other preparations of Botulinum toxin.
Danish: Det anbefalede antal enheder af Xeomin kan ikke erstattes med enheder af andre præparater med botulinumtoksin.
English: Merz Pharma GmbH & Co. KGaA Eckenheimer Landstraße 100 60318 Frankfurt/Main Germany
Danish: Merz Pharma GmbH & Co. KGaA Eckenheimer Landstraße 100 D-60318 Frankfurt am Main Tyskland
English: The incidence of Serious Adverse Events was low in all studies, with a similar frequency in both treatment groups.
Danish: Forekomsten af alvorlige bivirkninger var lav i alle undersøgelserne, og hyppigheden i de to behandlingsgrupper var ens. Der blev ikke rapporteret om behandlingsrelaterede alvorlige bivirkninger eller udtræden på grund af bivirkninger.
English: The HDA tests of the available samples were still in analysis, when the applicant's response was circulated.
Danish: Da ansøgerens besvarelse blev modtaget, var HDA-analyserne af de foreliggende prøver endnu ikke afsluttet.
English: Overall, the safety data shows that the prevalence of adverse events (AEs) was nearly identical in the Xeomin and in the Botox group (26.6% vs. 26%, respectively).
Danish: Overordnet viser sikkerhedsdataene, at forekomsten af bivirkninger er næsten den samme i de to behandlingsgrupper (26,6 % i Xeomin-gruppen og 26 % i Botox-gruppen).
English: the CHMP has recommended the granting of the Marketing Authorisation for which the Summary of Product Characteristics, Labelling and Package Leaflet are set out in Annex III for Xeomin.
Danish: Produktresumé, etikettering og indlægsseddel fremgår af bilag III for Xeomin.
English: Xeomin is reconstituted prior to use with sterile unpreserved sodium chloride 9 mg/ml (0.9%) solution for injection.
Danish: Xeomin rekonstitueres før brug med steril natriumchlorid 9 mg/ml injektionsvæske, opløsning, uden konserveringsmidler.
English: It remains unclear whether these deaths were induced by conventional preparations containing the Botulinum toxin type A complex or caused by a pre-existing cardiovascular disease.
Danish: Det er uklart, om disse dødsfald skyldtes standardpræparater med botulinum type A-toksinkompleks eller skyldtes en eksisterende hjerte-karsygdom.
English: Intubation and assisted ventilation will become necessary until improvement if paralysis of the respiratory muscles occurs.
Danish: I tilfælde af lammelse af åndedrætsmusklerne vil intubering og assisteret ventilation vil være nødvendigt, indtil der opnås bedring.
English: Strength
Danish: Træthed
English: When dissolved Xeomin is a clear and colourless solution which is free of particulate matter.
Danish: Efter fortynding udgør Xeomin en klar og farveløs opløsning uden partikelindhold.
English: A clinical pack is also available with 6 vials.
Danish: Fås også i hospitalspakning med 6 hætteglas.
English: Dissolved Xeomin is intended for injections into the muscle.
Danish: Efter fortynding er Xeomin beregnet til injektion i en muskel.
English: Two non-clinical studies, LPT10929 and LPT12444 with repeated high dose administration of Xeomin (25 LDU/animal in LPT10929 and 16-40LDU/animal in LPT12444) at very short injection intervals were performed in rabbits: - In LPT10929, in study week 12, two weeks after the last administration, Botulinum neurotoxin type A neutralising antibodies were found in 4 of 8 surviving rabbits treated with Botox, but in none of the 10 surviving rabbits treated with Xeomin.
Danish: Der blev udført to kortvarige ikke-kliniske undersøgelser i kaniner: LPT10929 og LPT12444 med gentagen administration af Xeomin i høje doser (25 LDU pr. dyr i LPT10929 og 16-40 LDU pr. dyr i LPT12444) med meget kort mellemrum mellem injektionerne:
English: Side effects related to spread of toxin distant from the site of administration have been reported very rarely (excessive muscle weakness, swallowing difficulties, lung infection or inflammation due to the inhalation of foreign substances (aspiration pneumonitis) with fatal outcome in some cases).
Danish: Der er set sjældne tilfælde af bivirkninger, der skyldtes spredning af toksinet fjernt fra administrationsstedet (voldsom muskelsvækkelse, lungeinfektion eller -betændelse på grund af inhalation af fremmedlegemer (aspirationspneumoni) - nogle af dem med dødelig udgang.
English: Medical supervision for up to several days and assisted ventilation may be necessary.
Danish: De kan have behov for lægetilsyn i flere dage og vejrtrækning gennem en respirator.
English: drooping eyelid (ptosis), dry eyes
Danish: Hængende øjenlåg (ptose), tørre øjne
English: For safe disposal, unused vials should be reconstituted with a small amount of water then sterilised under high pressure.
Danish: For sikker bortskaffelse skal ubrugte hætteglas rekonstitueres med lidt vand og dernæst steriliseres under højt tryk.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR CLINICAL PACK WITH 6 VIALS
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON TIL HOSPITALSPAKNING MED 6 HÆTTEGLAS
English: {Name and Address} <{tel}> <{fax}> <{e-mail}>
Danish: E E E E E
English: A female patient developed a nerve lesion affecting the arm (brachial plexopathy) two days after injection of a conventional preparation containing the Botulinum toxin type A complex for the treatment of twisted neck, with recovery after five months.
Danish: En kvindelig patient fik en nerveskade i armen (plexopathia brachialis) to dage efter injektion af et standardpræparat med botulinum type A-toksinkompleks til behandling af ufrivillig halsdrejning med raskmelding efter fem måneder.
English: For safe disposal, any unused vials should be dissolved with a small amount of water and then sterilised under high pressure (autoclaved).
Danish: For sikker bortskaffelse skal ikke anvendt indhold i hætteglas opløses med lidt vand og dernæst steriliseres under højt tryk (i en autoklave).
English: Careful testing of corneal sensation should be performed in patients with previous eye operations.
Danish: Patienter, der tidligere har fået øjenoperationer, skal testes omhyggeligt for følsomhed i cornea.
English: Diplopia may develop as a result of Botulinum neurotoxin type A diffusion into the inferior oblique.
Danish: Der kan udvikles diplopi som følge af diffusion af botulinum type Aneurotoksin ind i musculus obliquus inferior bulbi.
English: Powder for solution for injection 2 vials
Danish: Pulver til injektionsvæske, opløsning 2 hætteglas
English: Xeomin is injected into the medial and lateral orbicularis oculi of the upper lid and the lateral orbicularis oculi of the lower lid. Additional sites in the brow area, the lateral orbicularis and in the upper facial area may also be injected if spasms here interfere with vision.
Danish: Xeomin injiceres medialt og lateralt i musculus orbicularis oculi i det øvre øjenlåg og lateralt i musculus orbicularis oculi i det nedre øjenlåg.
English: • if you suffer from pronounced weakness or decreased muscle volume in the muscle where you will receive the injection
Danish: • hvis den muskel, hvor De skal have injektionen, er stærkt svækket eller dens størrelse er nedsat
English: Reconstituted Xeomin is a clear colourless solution free of particulate matter.
Danish: Efter rekonstitution fremstår Xeomin som en klar farveløs opløsning uden partikelindhold.
English: One death (colon carcinoma), assessed as unrelated to study treatment (Botox), was reported during the Phase II cervical dystonia study.
Danish: I fase II-undersøgelsen vedrørende cervikal dystoni blev der indberettet ét dødsfald (kolonkarcinom), der blev vurderet til at være uden sammenhæng med forsøgsbehandlingen (Botox).
English: • In the upper limb spasticity study (MRZ 0410) 144 patients entered the second injection cycle, in which doses up to 400 U of Xeomin are administered.
Danish: • I undersøgelsen vedrørende spasticitet i overekstremiteterne (MRZ 0410) har 144 patienter påbegyndt det andet injektionsforløb, hvor der bliver givet indtil 400 E Xeomin.
English: This can lead to an overlong exposure of the transparent front part of the eye (cornea).
Danish: Det kan føre til, at øjets hornhinde (den gennemsigtige hinde foran øjet) udsættes for længe for lægemidlet.
English: Merz Pharmaceuticals GmbH Eckenheimer Landstraße 100 60318 Frankfurt/Main
Danish: Merz Pharmaceuticals GmbH Eckenheimer Landstraße 100 D-60318 Frankfurt am Main
English: The two related adverse events were reported in the same patient who received 30/60 U of Xeomin (one injection site pain and one dysphagia).
Danish: De to medicinrelaterede bivirkninger optrådte begge samme patient, der fik 30/60 E Xeomin.
English: Merz Pharmaceuticals GmbH Eckenheimer Landstraße 100 60318 Frankfurt/Main Germany
Danish: Merz Pharmaceuticals GmbH Eckenheimer Landstraße 100 D-60318 Frankfurt am Main Tyskland
English: generalised weakness, flu like symptoms, malaise, dizziness, numbness, sleepiness (drowsiness), nasal inflammation (rhinitis), upper respiratory tract infection, nausea, oral dryness, skin sores, stiffness, increased muscle tone (hypertonia)
Danish: Udbredt svækkelse, influenzalignende symptomer, utilpashed, svimmelhed, følelsesløshed, søvnighed (sløvhed), betændelse i næsens slimhinder (rhinitis), øvre luftvejsinfektion, kvalme, mundtørhed, hudsår, stivhed, øget muskeltonus (hypertoni)
English: Take special care with Xeomin
Danish: Vær ekstra forsigtig med at bruge Xeomin
English: special form of inflammation of the cornea (superficial punctate keratitis), inability to close eye (lagophthalmos), eye irritation, fear of light (photophobia), tearing (lacrimation)
Danish: En særlig betændelse i øjets hornhinde (overfladisk punktformig keratitis), øjet kan ikke lukkes (øjenlågslammelse), øjenirritation, lysfølsomhed (fotofobi), tåreflåd
English: Dysphagia has been reported following injection to sites other than the cervical musculature.
Danish: Dysfagi er forekommet efter injektion andre steder end i halsmuskulaturen.
English: INFORMATION IN BRAILLE Justification for not including Braille accepted
Danish: INFORMATION I BRAILLE-SKRIFT Fritages fra krav om blindeskrift.
English: In the upper limb spasticity study (MRZ 0410) 144 patients entered the 2nd injection cycle, in which doses up to 400 U of Xeomin are administered.
Danish: I undersøgelsen vedrørende spasticitet i overekstremiteterne (MRZ 0410) har 144 patienter påbegyndt det andet injektionsforløb, hvor der gives indtil 400 E Xeomin.
English: The muscle mass and the degree of hypertrophy or atrophy are factors to be taken into consideration when selecting the appropriate dose.
Danish: Ved valg af en passende dosis skal der tages højde for muskelmassen og graden af hypertrofi eller atrofi.
English: dysphagia Uncommon: diarrhoea, dry mouth, vomiting, colitis
Danish: Diaré, mundtørhed, opkastning, colitis.
English: Additionally, the following side effects are known for the comparative compound containing conventional Botulinum toxin type A complex used in the clinical trials with Xeomin.
Danish: Derudover kendes følgende bivirkninger ved det sammenlignelige stof, der indeholder almindeligt botulinum type-A-toksinkompleks, og som er anvendt i undersøgelser af Xeomin hos patienter.
English: General disorders and administration site conditions Very common: pain, local weakness Common:
Danish: Almene symptomer og reaktioner på administrationsstedet Meget almindelige:
English: • The active substance is Clostridium Botulinum neurotoxin type A (150 kD), free of complexing proteins
Danish: • Aktivt stof: Clostridium botulinum type A-neurotoksin (150kD) uden kompleksdannende proteiner.
English: Treatment-related muscular weakness was observed in 1.1% of all patients randomised to Xeomin vs. 0.2% of all Botox patients, whereas the Phase Ib study MRZ-0113 showed no difference in the diffusion of both preparations in adjacent muscles.
Danish: Behandlingsrelateret muskelslaphed blev iagttaget hos 1,1 % af alle patienter, der var randomiseret til Xeomin, mod 0,2 % af alle Botox-patienter.
English: Uncommon: speech disorders (dysphonia), weakness (asthenia), muscle pain (myalgia), headache, shaking (tremor), eye pain, diarrhoea, dry mouth, vomiting, inflammation of the colon (colitis), skin rash, skin redness (erythema), itching (pruritus), sweating increased, skeletal pain, injection site inflammation, injection site tenderness
Danish: Ikke almindelige: Taleforstyrrelser (dysfoni), svækkelse (asteni), muskelsmerter (myalgi), hovedpine, rysten (tremor), øjensmerter, diaré, mundtørhed, opkastning, betændelse i tyktarmen (colitis), hududslæt, rødmen i huden (erytem), kløe (pruritus), øget svedtendens, skeletsmerter, betændelse ved injektionsstedet, ømhed ved injektionsstedet
English: Nevertheless, the mean change of surface EMG level in the sternocleidomastoid muscle, which is to be regarded as an objective parameter, showed a clear dose-trend of Xeomin.
Danish: Der var imidlertid klar sammenhæng mellem Xeomin-dosis og den gennemsnitlige ændring i det overfladiske EMGsignal fra musculus sternocleidomastoideus, hvilket må betragtes som en objektiv parameter.
English: 1.3 RECOMMENDATION
Danish: Fase 1
English: If you develop swallowing difficulties, speech or breathing disorders, please contact medical emergency services immediately or ask your relatives to do so.
Danish: Kontakt omgående lægen eller skadestuen, hvis De får synke-, tale- eller vejrtrækningsbesvær, eller bed Deres pårørende om at gøre det.
English: Human albumin Sucrose
Danish: Humant albumin
English: • if you suffer from any type of bleeding disorders
Danish: • hvis De har en blødningsforstyrrelse uanset art
English: In clinical trials with Botulinum toxin type A complex, it was reported that swallowing difficulties occur less frequently with low doses.
Danish: I undersøgelsesr af botulinum type A-neurotoksinkompleks hos patienterforekom synkebesvær mindre hyppigt med lave doser.