FrancophonIA/ELRC3.0 huggingface dataset:
English: Dependent on how comfortable you are, your doctor may then gradually increase the infusion rate.
Croatian: Ovisno kako se osjećate, liječnik može postupno povećati brzinu infuzije.
English: The maximum IgA content is 140 micrograms/ml.
Croatian: Najveći sadržaj IgA je 140 mikrograma/ml.
English: Overdose may lead to fluid overload and hyperviscosity, particularly in patients at risk, including elderly patients or patients with cardiac or renal impairment (see section 4.4 ).
Croatian: Predoziranje može dovesti do preopterećenja tekućinom i povećane viskoznosti, prvenstveno u rizičnih bolesnika, uključujući starije bolesnike ili bolesnike s oštećenjem funkcije srca ili bubrega (vidjeti dio 4.4).
English: This typically occurs within hours or days after IVIg administration and resolves spontaneously within 7 to 14 days.
Croatian: To se obično događa u roku od nekoliko sati ili dana nakon primjene i.v. imunoglobulina, a povlači se spontano unutar 7 do 14 dana.
English: For example, if you have an immunoglobulin A deficiency, you may have antibodies against immunoglobulin A in your blood.
Croatian: Na primjer, ako imate pomanjkanje imunoglobulina A, možda imate antitijela protiv imunoglobulina A u krvi.
English: The treatment required depends on the nature and severity of the adverse reaction.
Croatian: Potrebno liječenje ovisi o naravi i težini nuspojave.
English: If the treatment is effective long term treatment should be subject to the physicians discretion based upon the patient response and maintenance response.
Croatian: Ako je liječenje učinkovito, dugoročno liječenje treba provoditi prema odluci liječnika na temelju bolesnikova odgovora i odgovora na terapiju održavanja.
English: In these studies, a total of 83 subjects at least 2 years of age were treated with doses of 300 to 600 mg/kg body weight every 21 to 28 days for 6 to 12 months.
Croatian: U tim je ispitivanjima ukupan broj od 83 ispitanika u dobi od najmanje 2 godine starosti liječen dozama od 300 do 600 mg/kg tjelesne težine svakih 21 do 28 dana tijekom 6 do 12 mjeseci.
English: Coombs direct test positive, oxygen saturation decreased
Croatian: Pretrage pozitivan direktni Coombsov test, smanjeno zasićenje kisikom nepoznato
English: Please tell your doctor if you have a kidney disorder.
Croatian: Kažite liječniku ako imate poremećaj bubrega.
English: • Your doctor will also take special care if you have or had previously problems with your kidneys, or if you receive medicinal products that may harm your kidney (nephrotoxic medicinal products), as there is a very rare chance of acute kidney failure.
Croatian: • Liječnik će također posebno paziti ako imate ili ste ranije imali tegobe s bubrezima ili ako uzimate lijekove koji im mogu štetiti (nefrotoksični lijekovi), jer postoji vrlo rijetka mogućnost akutnog zatajenja bubrega.
English: • with undetectable IgA who have anti-IgA antibodies
Croatian: • u kojih se ne može detektirati IgA i koji imaju anti-IgA antitijela
English: These include careful selection of blood and plasma donors to make sure those at risk of carrying infections are excluded, and the testing of each donation and pools of plasma for signs of virus/infections.
Croatian: One uključuju oprezan izbor davatelja krvi i plazme kako bi se osiguralo isključivanje onih koji su rizični za prijenos infekcije te testiranje svake donacije i sakupljene plazme na znakove virusa/infekcija.
English: Treatment of patients who do not have sufficient antibodies (replacement therapy).
Croatian: Liječenje bolesnika koji nemaju dovoljno antitijela (nadomjesno liječenje).
English: 0.4 g/kg/day over 5 days (possible repeat of dosing in case of relapse).
Croatian: 0,4 g/kg/dan tijekom 5 dana (moguće je ponoviti doziranje u slučaju relapsa).
English: However, medicines that contain antibodies have been used in pregnant or breast-feeding women, and it has been shown that there are no harmful effects on the course of pregnancy or the baby to be expected.
Croatian: Međutim, lijekovi koji sadrže antitijela su se koristili u trudnica ili dojilja te se pokazalo da nemaju štetnih učinaka na tijek trudnoće ili na bebu koja se očekuje.
English: • Guillain Barré syndrome.
Croatian: • Guillain-Barréovom sindromu.
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će dodatne farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: • in patients with an untreated infection or underlying chronic inflammation.
Croatian: • u bolesnika s neliječenom infekcijom ili podležećom kroničnom upalom.
English: This also applies to unknown or emerging viruses and other pathogens.
Croatian: To se također odnosi na nepoznate ili novootkrivene viruse i ostale patogene.
English: This should be taken into account by physicians, since initiation of treatment for true hyponatremia (i.e. decreasing serum free water) in these patients may lead to a further increase in serum viscosity and a possible predisposition to thromboembolic events.
Croatian: Liječnici to moraju uzeti u obzir, jer započinjanje liječenja u bolesnika sa stvarnom hiponatrijemijom (npr. smanjenje slobodne vode u serumu) može dovesti do daljnjeg povećanja viskoznosti seruma i moguće predispozicije za tromboembolijske događaje.
English: Patients with a disease that is associated with multiple inflammations of the nerves in the whole body (Guillain Barré syndrome).
Croatian: Bolesnici s bolešću povezanom s višestrukim upalama živaca u cijelome tijelu (Guillain-Barréov sindrom).
English: Administration of KIOVIG can lead to false positive readings in assays that depend on detection of beta-D-glucans for diagnosis of fungal infections.
Croatian: Primjena lijeka KIOVIG može dovesti do lažno pozitivnih očitanja u testovima koji se temelje na otkrivanju beta-D-glukana za dijagnozu gljivičnih infekcija.
English: No dose adjustment unless clinically warranted, see section 4.4.
Croatian: Nema prilagodbe doze osim ako je klinički potrebno, vidjeti dio 4.4.
English: • If KIOVIG is administered at a high rate, if you suffer from a condition with low antibody levels in your blood (hypo- or agammaglobulinemia), if you have not received this medicine before or if there has been a long interval (e.g. several weeks) since you last received it, there may be a higher risk of side effects.
Croatian: • Ako se KIOVIG primjenjuje velikom brzinom, ako patite od stanja s niskom razinom antitijela u krvi (hipo- ili agamaglobulinemija), ako niste prethodno primali ovaj lijek ili ako je prošlo dulje vrijeme (npr. nekoliko tjedana) od prethodne primjene, može biti veći rizik od nuspojava.
English: KIOVIG also contains certain antibodies that can prevent an infection with hepatitis A virus and parvovirus B19.
Croatian: KIOVIG također sadrži neka antitijela koja mogu spriječiti infekciju s hepatitis A virusom i parvovirusom B19.
English: • Your doctor will take special care if you are overweight, elderly, diabetic, or if you suffer from high blood pressure, low blood volume (hypovolaemia), or problems with your blood vessels (vascular diseases).
Croatian: • Liječnik će posebno paziti ako ste prekomjerne težine, stariji, ako bolujete od dijabetesa ili visokog krvnog tlaka, niskog volumena krvi (hipovolemija) ili ako imate problema s krvnim žilama (krvožilne bolesti).
English: The ability to drive and operate machines may be impaired by some adverse reactions associated with KIOVIG.
Croatian: Sposobnost upravljanja vozilima i rada na strojevima može biti umanjena nekim nuspojavama povezanim s primjenom lijeka KIOVIG.
English: Medicines like KIOVIG are used in patients who do not have enough antibodies in their blood and tend to get frequent infections.
Croatian: Lijekovi kao KIOVIG koriste se u bolesnika koji nemaju dovoljno vlastitih antitijela u krvi i skloni su čestim infekcijama.
English: Passive transmission of antibodies to erythrocyte antigens, e.g. A, B, D, may interfere with some serological tests for red cell antibodies, for example the direct antiglobulin test (DAT, direct Coombs' test).
Croatian: Pasivno prenošenje antitijela na antigene eritrocita, npr. A, B, D, može interferirati s nekim serološkim ispitivanjima za antitijela crvenih krvnih stanica, primjerice direktni antiglobulinski test (DAT, direktni Coombsov test).
English: Pharmacokinetic parameters for the product are summarized in the table below.
Croatian: Farmakokinetički parametri lijeka su sažeti u donjoj tablici.
English: After infusion of immunoglobulin the transitory rise of the various passively transferred antibodies in the patient's blood may result in misleading positive results in serological testing.
Croatian: Nakon infuzije imunoglobulina, prolazno povećanje raznih pasivno prenesenih antitijela može u krvi bolesnika dati lažno pozitivne rezultate seroloških testova.
English: Depending on your doctor's decision the rate of infusion can be slowed or the infusion can be stopped altogether.
Croatian: Ovisno o odluci Vašeg liječnika, infuzija se može usporiti ili potpuno prekinuti.
English: Patients who experience adverse reactions during treatment should wait for these to resolve before driving or operating machines.
Croatian: Bolesnici koji iskuse nuspojave tijekom liječenja moraju pričekati da iste prestanu prije nego počnu upravljati vozilima ili raditi sa strojevima.
English: OUTER CARTON (1G, 2.5G, 5G, 10G, 20G AND 30G)
Croatian: VANJSKO PAKIRANJE (1G, 2,5G, 5G, 10G, 20G I 30G)
English: The treatment can be repeated if relapse occurs.
Croatian: U slučaju pojave relapsa, liječenje se može ponoviti.
English: • The product must be brought to room or body temperature before use.
Croatian: • Lijek se mora zagrijati na sobnu ili tjelesnu temperaturu prije uporabe.
English: It has a distribution of immunoglobulin G subclasses closely proportional to that in native human plasma.
Croatian: Ima distribuciju imunoglobulin G podskupina usko proporcionalnu onoj u izvornoj ljudskoj plazmi.
English: Treatment of patients with certain inflammatory disorders (immunomodulation).
Croatian: Liječenje bolesnika s nekim upalnim poremećajima (imunomodulacija).
English: The safety of this medicinal product for use in human pregnancy has not been established in controlled clinical trials and therefore it should only be given with caution to pregnant women and breast-feeding mothers.
Croatian: Sigurnost ovog lijeka za primjenu u trudnoći u žena nije ustanovljena u kontroliranim kliničkim ispitivanjima te se stoga u trudnica i dojilja smije primjenjivati samo s oprezom.
English: The product should be brought to room or body temperature before use.
Croatian: Lijek treba zagrijati na sobnu ili tjelesnu temperaturu prije uporabe.
English: VIAL LABEL (1G)
Croatian: NALJEPNICA NA BOČICI (1G)
English: 2 g/kg should be administered as a single dose.
Croatian: 2 g/kg mora se primijeniti u jednokratnoj dozi.
English: • No clinical trials have been made with KIOVIG in pregnant or breast-feeding women.
Croatian: • Nisu provedena klinička ispitivanja s lijekom KIOVIG u trudnica ili dojilja.
English: Pharmacotherapeutic group: immune sera and immunoglobulins: immunoglobulins, normal human, for intravascular administration, ATC code: J06BA02
Croatian: Farmakoterapijska skupina: imunoserumi i imunoglobulini: imunoglobulini, normalni ljudski, za intravaskularnu primjenu, ATK oznaka: J06BA02
English: Human normal immunoglobulin ……………100 mg (purity of at least 98% IgG)
Croatian: Imunoglobulin normalni, ljudski ……………100 mg (čistoće od najmanje 98% IgG)
English: • monitoring of serum creatinine levels
Croatian: • praćenje razina kreatinina u serumu
English: If you use more KIOVIG than you should
Croatian: Ako primijenite više lijeka KIOVIG nego što ste trebali
English: You may have to wait for up to 1 year after receiving immunoglobulins before you receive your measles vaccine.
Croatian: Možda ćete morati pričekati i do godine dana nakon što primite imunoglobuline prije nego primite cjepivo protiv ospica.
English: The dose recommendations are summarised in the following table:
Croatian: Preporuke za doziranje sažete su u sljedećoj tablici:
English: Table 1 shows the adverse reactions from clinical trials and Table 2 shows the post-marketing ARs.
Croatian: Tablica 1 prikazuje nuspojave iz kliničkih ispitivanja, a Tablica 2 prikazuje nuspojave nakon stavljanja lijeka u promet.
English: Patients exhibiting such signs and symptoms should receive a thorough neurological examination, including CSF studies, to rule out other causes of meningitis.
Croatian: U bolesnika u kojih se pojave takvi znakovi i simptomi, potrebno je provesti temeljiti neurološki pregled, uključujući analizu cerebrospinalne tekućine, kako bi se isključili drugi uzroci meningitisa.
English: Hypersensitivity to human immunoglobulins, especially in patients with antibodies against IgA.
Croatian: Preosjetljivost na ljudske imunoglobuline, posebno u bolesnika s antitijelima na IgA.
English: The dose regimen should achieve a trough level of IgG (measured before the next infusion) of at least 5 to 6 g/L.
Croatian: Doziranjem se mora postići najniža koncentracija IgG (mjerena prije sljedeće infuzije) od najmanje 5 do 6 g/l.
English: Patients with a disease which results in multiple inflammations of several organs of the body (Kawasaki disease).
Croatian: Bolesnici s bolešću čiji su rezultat višestruke upale nekoliko tjelesnih organa (Kawasakijeva bolest).
English: Maximum immunoglobulin A (IgA) content: 140 micrograms/ml.
Croatian: Najveći sadržaj imunoglobulina A (IgA) je: 140 mikrograma/ml.
English: Human protein, 100 mg/ml, at least 98% is IgG.
Croatian: Ljudski protein, 100 mg/ml, od kojeg je IgG najmanje 98%.
English: Three to six months are required after the initiation of therapy for equilibration (steady-state IgG levels) to occur.
Croatian: Potrebno je tri do šest mjeseci kako bi se postigla ravnoteža (koncentracija IgG-a u stanju dinamičke ravnoteže) nakon početka terapije.
English: Human normal immunoglobulin contains the IgG antibodies present in the normal population.
Croatian: Ljudski normalni imunoglobulin sadrži IgG antitijela prisutna u normalnoj populaciji.
English: The syndrome usually begins within several hours to 2 days following IVIg treatment.
Croatian: Sindrom se obično javlja unutar nekoliko sati do 2 dana nakon početka liječenja i.v. imunoglobulinima.
English: Frequency, type and severity of adverse reactions in children are the same as in adults.
Croatian: Učestalost, vrsta i težina nuspojava u djece bile su iste kao i u odraslih.
English: For safety with respect to transmissible agents, see section 4.4.
Croatian: Za sigurnost obzirom na prijenos infektivnih agensa, vidjeti dio 4.4.
English: Human normal immunoglobulin contains mainly immunoglobulin G (IgG) with a broad spectrum of antibodies against infectious agents.
Croatian: Ljudski normalni imunoglobulin sadrži većinom imunoglobulin G (IgG) uz široki spektar antitijela protiv uzročnika infekcije.
English: In most cases, risk factors have been identified, such as pre-existing renal insufficiency, diabetes mellitus, hypovolaemia, overweight, concomitant nephrotoxic medicinal products, age over 65, sepsis, hyperviscosity or paraproteinemia.
Croatian: U većini slučajeva bili su identificirani faktori rizika, kao što su prethodno postojeća insuficijencija bubrega, dijabetes, hipovolemija, prekomjerna tjelesna težina, istovremena primjena nefrotoksičnih lijekova, dob iznad 65 godina, sepsa, hiperviskoznost ili paraproteinemija.
English: Replacement therapy in secondary immunodeficiency
Croatian: Nadomjesna terapija u sekundarnoj imunodeficijenciji
English: While these reports of renal dysfunction and acute renal failure have been associated with the use of many of the licensed IVIg products containing various excipients such as sucrose, glucose and maltose, those containing sucrose as a stabiliser accounted for a disproportionate share of the total number.
Croatian: Iako su ove prijave bubrežne disfunkcije i akutnog zatajenja bubrega povezane s primjenom mnogih odobrenih i.v. imunoglobulinskih lijekova koji sadrže različite pomoćne tvari poput saharoze, glukoze i maltoze, oni koji sadrže saharozu kao stabilizator čine nesrazmjerni dio ukupnog broja.
English: This also applies to any unknown or emerging viruses or other types of infections.
Croatian: To se također odnosi na nepoznate ili na viruse tek u nastajanju ili ostale vrste infekcija.
English: Dose based on bodyweight may require adjustment in underweight or overweight patients.
Croatian: Za dozu koja se temelji na tjelesnoj težini može biti potrebna prilagodba u bolesnika premale ili prevelike tjelesne težine.
English: When slowing or stopping the infusion may be required
Croatian: Kada može biti potrebno usporiti ili prekinuti infuziju
English: For obtaining an immunoglobulin solution of 50 mg/ml (5%), KIOVIG 100 mg/ml (10%) should be diluted with an equal volume of the glucose solution.
Croatian: Za dobivanje otopine imunoglobulina od 50 mg/ml (5%), KIOVIG 100 mg/ml (10%) treba razrijediti s jednakim volumenom otopine glukoze.
English: Each vial of 10 ml contains: 1 g of human normal immunoglobulin Each vial of 25 ml contains: 2.5 g of human normal immunoglobulin Each vial of 50 ml contains: 5 g of human normal immunoglobulin Each vial of 100 ml contains: 10 g of human normal immunoglobulin Each vial of 200 ml contains: 20 g of human normal immunoglobulin Each vial of 300 ml contains: 30 g of human normal immunoglobulin
Croatian: Jedna bočica od 10 ml sadrži: 1 g imunoglobulina normalnog, ljudskog Jedna bočica od 25 ml sadrži: 2,5 g imunoglobulina normalnog, ljudskog Jedna bočica od 50 ml sadrži: 5 g imunoglobulina normalnog, ljudskog Jedna bočica od 100 ml sadrži: 10 g imunoglobulina normalnog, ljudskog Jedna bočica od 200 ml sadrži: 20 g imunoglobulina normalnog, ljudskog Jedna bočica od 300 ml sadrži: 30 g imunoglobulina normalnog, ljudskog
English: • You will be carefully observed during the infusion period with KIOVIG to make sure that you do not suffer a reaction.
Croatian: • Zdravstveni radnici pomno će Vas promatrati tijekom trajanja infuzije lijeka KIOVIG kako bi bilo sigurno da nemate reakciju.
English: Hypogammaglobulinaemia (<4 g/l) in patients after allogeneic haematopoietic stem cell transplantation
Croatian: Hipogamaglobulinemija (<4 g/l) u bolesnika nakon alogene transplantacije hematopoetskih matičnih stanica
English: Patients with inborn lack of antibody production (primary immunodeficiency syndromes).
Croatian: Bolesnici s prirođenim nedostatkom stvaranja antitijela (sindromi primarne imunodeficijencije).
English: • Primary immunodeficiency syndromes (PID) with impaired antibody production (see section 4.4).
Croatian: • Sindromima primarne imunodeficijencije s poremećenim stvaranjem antitijela (vidjeti dio 4.4).
English: 1 g/kg over 1-2 consecutive days every 3 weeks.
Croatian: 1 g/kg tijekom 1-2 uzastopna dana svaka 3 tjedna.
English: To reduce the rate of bacterial infection, it may be necessary to increase the dose and aim for higher trough levels.
Croatian: Kako bi se smanjila stopa bakterijske infekcije, možda će biti potrebno povećati dozu kako bi se postigla veća vrijednost najniže koncentracije.
English: The tables presented below are according to the MedDRA system organ classification (SOC and Preferred Term Level).
Croatian: Tablice su u skladu s klasifikacijom organskih sustava prema MedDRA-i (SOC i razina preporučenog pojma).
English: After administration of this product, an interval of 3 months should elapse before vaccination with live attenuated virus vaccines.
Croatian: Nakon primjene ovog lijeka mora se napraviti razmak od 3 mjeseca prije cijepljenja sa živim atenuiranim virusnim cjepivima.
English: Immunoglobulins are excreted into the milk and may contribute to protecting the neonate from pathogens which have a mucosal portal of entry.
Croatian: Imunoglobulini se izlučuju u mlijeko i mogu doprinijeti zaštiti novorođenčeta od patogena kojima je sluznica ulazno mjesto infekcije.
English: The trough levels should be maintained above 5g/l.
Croatian: Najniže koncentracije lijeka moraju se održavati iznad 5 g/l.
English: When medicines are made from human blood or plasma, a number of measures are put in place to prevent infections being passed on to patients.
Croatian: Kada se lijekovi proizvode iz ljudske krvi ili plazme, postoji velik broj mjera koje su uvedene kako bi se spriječio prijenos infekcija na bolesnike.
English: In these conditions, immunoglobulins may increase the risk of cardiac infarction, stroke, lung embolism, or deep vein thrombosis, although only in very rare cases.
Croatian: U tim stanjima, imunoglobulini mogu povećati rizik za infarkt srca, moždani udar, emboliju pluća ili duboku vensku trombozu, premda samo u vrlo rijetkim slučajevima.
English: Patients who do not have enough blood platelets (primary immune thrombocytopenia, ITP), and who are at high risk of bleeding or will have surgery in the near future.
Croatian: Bolesnici koji nemaju dovoljno trombocita u krvi (primarna imunološka trombocitopenija) i oni s visokim rizikom za krvarenje ili oni koji će u bliskoj budućnosti imati kirurški zahvat.
English: VIAL LABEL (2.5G)
Croatian: NALJEPNICA NA BOČICI (2,5G)
English: Other routes of administration have not been evaluated.
Croatian: Ostali načini primjene nisu ispitani.
English: Table 1 Frequency of Adverse Reactions (ADRs) in clinical studies with KIOVIG MedDRA System Organ Class (SOC)
Croatian: Tablica 1 Učestalost nuspojava - u kliničkim ispitivanjima s lijekom KIOVIG MedDRA klasifikacija organskih sustava (SOC)
English: Immunomodulation in adults, and children and adolescents (0-18 years) in:
Croatian: Imunomodulacija u odraslih te djece i adolescenata (0-18 godina) pri:
English: Immunoglobulins are normal constituents of the human body.
Croatian: Imunoglobulini su normalni sastojci ljudskog tijela.
English: The dose interval when steady state has been reached varies from 3-4 weeks.
Croatian: Kada je postignuto stanje dinamičke ravnoteže, razmak između doziranja varira od 3 do 4 tjedna.
English: Cases of reversible aseptic meningitis and rare cases of transient cutaneous reactions (including cutaneous lupus erythematosus - frequency unknown) have been observed with human normal immunoglobulin.
Croatian: Zapaženi su slučajevi reverzibilnog aseptičkog meningitisa i rijetki slučajevi prolaznih kožnih reakcija (uključujući kožni eritemski lupus - učestalost nepoznata) pri primjeni ljudskog normalnog imunoglobulina.
English: • adequate hydration prior to the initiation of the infusion of IVIg
Croatian: • odgovarajuću hidraciju prije početka infuzije i.v. imunoglobulina
English: If well tolerated, the rate of administration may gradually be increased to a maximum of 6 ml/kg bodyweight/hour.
Croatian: Ako se dobro podnosi, brzina primjene se može postepeno povećati do najviše 6 ml/kg tjelesne težine/sat.
English: Therefore, after receiving immunoglobulins you may have to wait up to 3 months before receiving your live-attenuated vaccine.
Croatian: Zbog toga ćete nakon što primite imunoglobuline možda trebati pričekati do 3 mjeseca prije nego primite živo atenuirano cjepivo.
English: The dose required to achieve a trough level of 5-6 g/L is of the order of 0.2-0.8 g/kg/month.
Croatian: Doza potrebna za postizanje najniže koncentracije od 5-6 g/l reda je veličine od 0,2-0,8 g/kg/mjesec.
English: • Multifocal Motor Neuropathy (MMN).
Croatian: • Multifokalnoj motoričkoj neuropatiji (MMN).
English: Since KIOVIG contains trace amounts of immunoglobulin A (less than 0.14 mg/ml), you might get an allergic reaction.
Croatian: A u tragovima (manje od 0,14 mg/ml), možete dobiti alergijsku reakciju.
English: 121 87 to 137 99 75 to 121 104 96 to 114
Croatian: 121 87 do 137 99 75 do 121 104 96 do 114
English: Very rarely: Thromboembolic reactions such as myocardial infarction, stroke, pulmonary embolism, and deep vein thromboses.
Croatian: Vrlo rijetko: tromboembolijske reakcije kao što su infarkt miokarda, moždani udar, plućna embolija i duboka venska tromboza.