FrancophonIA/ELRC3.0 huggingface dataset:
English: Tell your doctor immediately before or after taking this medicine, if you notice any of the following symptoms, which could be a sign of another, more serious, disease.
Slovenian: Zdravniku morate takoj, pred ali po jemanju tega zdravila povedati, če opazite katerega od naslednjih simptomov, ki so lahko znak druge, resnejše bolezni:
English: If you have very low levels of magnesium, you may also have low levels of calcium and/or potassium in your blood.
Slovenian: Če imate zelo nizko koncentracijo magnezija, imate lahko v krvi tudi nizko koncentracijo kalcija in/ali kalija.
English: The reactions are classified according to MedDRA frequency convention: very common (≥ 1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Slovenian: Učinki so razvrščeni glede na dogovor o pogostnosti MedDRA: zelo pogosti (> 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: There is insufficient information on the effects of esomeprazole in newborns/infants.
Slovenian: O učinkih esomeprazola pri novorojenčkih in dojenčkih ni dovolj informacij.
English: Hypersensitivity to the active substance, substituted benzimidazoles or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na učinkovino, substituirane benzimidazole ali katerokoli pomožno snov, navedeno v poglavju 6.1.
English: Medicinal products with pH dependent absorption
Slovenian: Zdravila, katerih absorpcija je odvisna od pH
English: Adverse reactions not observed in clinical studies, but seen in animals at exposure levels similar to clinical exposure levels and with possible relevance to clinical use were as follows:
Slovenian: Neželeni učinki, ki jih v kliničnih študijah niso zabeležili, opazili pa so jih pri živalih ob izpostavljenostih, podobnih kliničnim izpostavljenostim, in bi lahko bili pomembni za klinično uporabo, so:
English: Heartburn can be a result of eating too much, eating high fat food, eating too quickly and drinking lots of alcohol.
Slovenian: Zgaga je lahko posledica prenajedanja, uživanja hrane z veliko vsebnostjo maščob, prehitrega zaužitja hrane in pitja velike količine alkohola.
English: Capsules
Slovenian: kapsule
English: Pfizer Consumer Manufacturing Italy S.r.l., Via Nettunense, 90, 04011, Aprilia (LT), Italy.
Slovenian: Pfizer Consumer Manufacturing Italy S.r.l., Via Nettunense, 90, 04011 Aprilia (LT), Italija
English: Patients should not take Nexium Control as a long term preventive medicinal product.
Slovenian: Bolniki zdravila Nexium Control ne smejo jemati kot zdravila za dolgoročno preventivo.
English: Due to limited experience in patients with severe renal insufficiency, such patients should be treated with caution (see section 5.2).
Slovenian: Izkušenj pri bolnikih s hudo insuficienco ledvic je malo, zato je treba takšne bolnike zdraviti previdno (glejte poglavje 5.2).
English: A dose adjustment of esomeprazole is not regularly required in either of these situations.
Slovenian: V nobeni od teh okoliščin odmerka esomeprazola praviloma ni treba prilagoditi.
English: • Medicines that are used to thin your blood, such as warfarin.
Slovenian: • zdravila, ki se uporabljajo za redčenje krvi, na primer varfarin.
English: What are the symptoms of heartburn?
Slovenian: Kakšni so simptomi zgage?
English: You should specifically tell your doctor or pharmacist if you are taking clopidogrel (used to prevent blood clots).
Slovenian: Zdravniku ali farmacevtu morate posebej povedati, če jemljete klopidogrel (zdravilo, ki se uporablja za preprečevanje nastajanja krvnih strdkov).
English: • You can take your capsule at any time of the day either with food or on an empty stomach.
Slovenian: • Kapsulo lahko vzamete kadarkoli v teku dneva, s hrano ali na prazen želodec.
English: A reinforced monitoring of tacrolimus concentrations as well as renal function (creatinine clearance) should be performed, and the dose of tacrolimus adjusted if needed.
Slovenian: Intenzivneje je treba nadzirati koncentracijo takrolimusa in delovanje ledvic (očistek kreatinina), odmerek takrolimusa pa prilagoditi, če je treba.
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicinal product.
Slovenian: Bolniki z redko dedno intoleranco za fruktozo, malabsorbcijo glukoze/galaktoze ali pomanjkanjem saharoza-izomaltaze ne smejo jemati tega zdravila.
English: • Increased liver enzymes shown in blood tests that check how the liver is working.
Slovenian: • zvišane vrednosti jetrnih encimov, ki jih pokažejo izvidi krvnih preiskav, s katerimi preverjamo delovanje jeter
English: You should not use this medicine during breast-feeding.
Slovenian: Tega zdravila ne uporabljajte med dojenjem.
English: They work by reducing the amount of acid that your stomach produces.
Slovenian: Delujejo tako, da zmanjšajo količino kisline, ki nastaja v želodcu.
English: • You lose a lot of weight for no reason.
Slovenian: • hujšanje brez razloga,
English: • Low levels of magnesium in the blood.
Slovenian: • nizka koncentracija magnezija v krvi.
English: A moderate amount of data on pregnant women (between 300-1,000 pregnancy outcomes) indicate no malformative or feto/ neonatal toxicity of esomeprazole.
Slovenian: Zmeren obseg podatkov o nosečnicah (od 300 do 1.000 izidov nosečnosti) ne kaže, da bi esomeprazol povzročal malformacije, fetotoksične učinke ali toksične učinke na novorojenčka.
English: • You can take your tablet at any time of the day either with food or on an empty stomach.
Slovenian: • Tableto lahko vzamete kadarkoli v teku dneva, s hrano ali na prazen želodec.
English: Approximately 2.9±1.5% of the population lack a functional CYP2C19 enzyme and are called poor metabolisers.
Slovenian: Približno 2,9 ± 1,5 % populacije nima funkcionalnega CYP2C19 in jih imenujemo slabi metabolizatorji.
English: You may also notice that when you lie down, that your heartburn gets worse.
Slovenian: Morda boste opazili, da se zgaga poslabša, kadar se uležete.
English: • You have problems or pain when swallowing.
Slovenian: • težave ali bolečine pri požiranju,
English: If you have persistent or longstanding, frequently recurring symptoms even after treatment with this medicine, you should contact your doctor.
Slovenian: Če imate trdovratne ali dolgotrajne, pogosto ponavljajoče se simptome tudi še po zdravljenju s tem zdravilom, se morate posvetovati z zdravnikom.
English: However, the maximum levels of inhibition of (ADP induced) platelet aggregation in these subjects were the same in both groups.
Slovenian: Največja raven zavrtja (z ADP inducirane) agregacije trombocitov pa je bila pri preiskovancih v obeh skupinah enaka.
English: • The recommended dose is one tablet a day.
Slovenian: • Priporočeni odmerek je ena tableta na dan.
English: Patients over 55 years taking any non-prescription indigestion or heartburn remedy on a daily basis should inform their pharmacist or doctor.
Slovenian: Bolniki, starejši od 55 let, ki vsak dan jemljejo brez recepta dostopna zdravila proti želodčnim težavam ali zgagi, morajo o tem obvestiti farmacevta ali zdravnika.
English: This increase is dose-dependent and results in a more than dose proportional increase in AUC after repeated administration.
Slovenian: Povečanje je odvisno od odmerka in po večkratni uporabi povzroči več kot odmerku sorazmerno povečanje AUC.
English: No other liquids should be used as the enteric coating may be dissolved.
Slovenian: Drugih tekočin se ne sme uporabljati, ker se lahko gastrorezistentna obloga raztopi.
English: Symptoms associated with acid reflux (such as heartburn and acid regurgitation) were evaluated retrospectively over a 24 hour period.
Slovenian: Simptome, povezane z refluksom želodčne kisline (kot sta zgaga in regurgitacija kisline), so ocenjevali retrospektivno v 24-urnem obdobju.
English: To avoid this interference, Nexium Control treatment should be stopped for at least 5 days before CgA measurements (see section 5.1).
Slovenian: Da bi to preprečili, je treba vsaj pet dni pred meritvami CgA prekiniti zdravljenje z zdravilom Nexium Control (glejte poglavje 5.1).
English: Do not use if you are allergic to esomeprazole or any of the other ingredients of this medicine.
Slovenian: Ne jemljite zdravila, če ste alergični na esomeprazol ali katerokoli drugo sestavino tega zdravila.
English: • You have severe or persistent diarrhoea; esomeprazole has been associated with a small increased risk of infectious diarrhoea.
Slovenian: • huda ali trdovratna driska; esomeprazol je povezan z nekoliko večjim tveganjem za infekcijsko drisko,
English: Esomeprazole has minor influence on the ability to drive or use machines.
Slovenian: Esomeprazol ima manjši vpliv na sposobnost vožnje in upravljanja strojev.
English: It belongs to a group of medicines called ‘proton pump inhibitors'.
Slovenian: Spada v skupino zdravil, ki jih imenujemo "zaviralci protonske črpalke".
English: If you notice any of the following serious side effects, stop taking Nexium Control and contact a doctor immediately:
Slovenian: Če opazite katerega od naslednjih resnih neželenih učinkov, nehajte jemati zdravilo Nexium Control in se takoj posvetujte z zdravnikom:
English: Due to the similar pharmacodynamic effects and pharmacokinetic properties of omeprazole and esomeprazole, concomitant administration with esomeprazole and atazanavir is not recommended and concomitant administration with esomeprazole and nelfinavir is contraindicated (see section 4.3 and 4.4).
Slovenian: Zaradi podobnih farmakodinamičnih učinkov in farmakokinetičnih značilnosti omeprazola in esomeprazola sočasna uporaba esomeprazola in atazanavirja ni priporočljiva, sočasna uporaba esomeprazola in nelfinavirja pa je kontraindicirana (glejte poglavji 4.3 in 4.4).
English: • The active substance is esomeprazole.
Slovenian: • Učinkovina je esomeprazol.
English: If lesions occur, especially in sun-exposed areas of the skin, and if accompanied by arthralgia, the patient should seek medical help promptly and the health care professional should consider stopping Nexium Control.
Slovenian: Če se pojavijo lezije, zlasti na koži, ki je izpostavljena soncu, in sočasna artralgija, mora bolnik takoj poiskati zdravniško pomoč, zdravstveni delavec pa mora razmisliti o prekinitvi zdravljenja z zdravilom Nexium Control.
English: However, patients with severe liver impairment should be advised by a doctor before taking Nexium Control (see sections 4.4 and 5.2).
Slovenian: Bolnikom s hudo okvaro jeter pa je treba naročiti, naj se pred jemanjem zdravila Nexium Control posvetujejo z zdravnikom (glejte poglavji 4.4 in 5.2).
English: - If you are allergic to medicines containing other proton pump inhibitors (e.g. pantoprazole,
Slovenian: - Če ste alergični na zdravila, ki vsebujejo druge zaviralce protonske črpalke (npr. pantoprazol,
English: Almost 80% of an oral dose of esomeprazole is excreted as metabolites in the urine, the remainder in the faeces.
Slovenian: Skoraj 80 % peroralnega odmerka esomeprazola se izloči v obliki presnovkov v urinu, preostanek pa v blatu.
English: The median time to first resolution of night-time heartburn was 1 day, statistically significant compared to placebo in one study (p=0.048) and approaching significance in the other (p=0.069).
Slovenian: Mediana časa do prvega prenehanja nočne zgage je bila en dan, kar je bilo v eni študiji statistično pomembno v primerjavi s placebom (p = 0,048) in skoraj statistično pomembno v drugi študiji (p = 0,069).
English: • The recommended dose is one capsule a day.
Slovenian: • Priporočeni odmerek je ena kapsula na dan.
English: • Put the tablet in a glass of still (non-fizzy) water.
Slovenian: • Tableto dajte v kozarec negazirane vode (vode brez mehurčkov).
English: Metabolism and nutrition disorders peripheral oedema hyponatraemia hypomagnesaemia; severe hypomagnesaemia can correlate with hypocalcaemia; hypomagnesaemia may also result in hypokalaemia
Slovenian: Presnovne in prehranske motnje periferni edemi hiponatriemija hipomagneziemija, huda hipomagneziemija je lahko povezana s hipokalciemijo; hipomagneziemija lahko povzroči hipokaliemijo
English: Esomeprazole 20 mg should not be exceeded.
Slovenian: Odmerek esomeprazola ne sme preseči 20 mg.
English: +K+-ATPase
Slovenian: +K+-ATPazo (kislinsko črpalko).
English: This could be ‘Stevens-Johnson syndrome' or ‘toxic epidermal necrolysis', seen very rarely.
Slovenian: To je lahko t. i. Stevens-Johnsonov sindrom ali toksična epidermalna nekroliza; pojavi se zelo redko.
English: Talk to your pharmacist or doctor if:
Slovenian: Posvetujte se z zdravnikom ali farmacevtom, če:
English: Absorption of esomeprazole is rapid, with peak plasma levels occurring approximately 1-2 hours after dose.
Slovenian: Absorpcija esomeprazola je hitra, najvišjo koncentracijo v plazmi pa doseže približno 1 do 2 uri po odmerku.
English: Corresponding proportions for esomeprazole 40 mg were 97%, 92% and 56%.
Slovenian: Po 40 mg esomeprazola so bili ti deleži 97 %, 92 % in 56 %.
English: Combination with other medicinal products
Slovenian: Kombinacija z drugimi zdravili
English: • To make sure that you have drunk all of the medicine, rinse the glass very well with half a glass of water and drink it.
Slovenian: • Da boste popili zares vse zdravilo, kozarec nato zelo dobro splaknite s pol kozarca vode in to vodo popijte.
English: Nexium Control is not meant to bring immediate relief.
Slovenian: Zdravilo Nexium Control ni namenjeno takojšnjemu olajšanju težav.
English: You may take this medicine with antacids (e.g. magaldrate, alginic acid, sodium bicarbonate, aluminium hydroxide, magnesium carbonate or combinations of these) if needed.
Slovenian: To zdravilo lahko jemljete z antacidi (na primer z magaldratom, alginsko kislino, natrijevim bikarbonatom, aluminijevim hidroksidom, magnezijevim karbonatom ali njihovimi kombinacijami), če je to potrebno.
English: The apparent volume of distribution at steady state in healthy subjects is approximately 0.22 l/kg body weight.
Slovenian: Navidezni volumen porazdelitve v stanju dinamičnega ravnovesja je pri zdravih preiskovancih približno 0,22 l/kg telesne mase.
English: Tell your doctor or pharmacist if you are taking any of the following medicines:
Slovenian: Zdravniku ali farmacevtu morate povedati, če jemljete katero od naslednjih zdravil:
English: Esomeprazole should not be used during breast-feeding.
Slovenian: Esomeprazola se med obdobjem dojenja ne sme uporabljati.
English: • You have ever had a skin reaction after treatment with a medicine similar to Nexium Control that reduces stomach acid.
Slovenian: • ste že kdaj imeli kožno reakcijo po zdravljenju z zdravilom, podobnim zdravilu Nexium
English: Patients should consult their doctor before taking this medicinal product if they are due to have an endoscopy or urea breath test.
Slovenian: Pred jemanjem tega zdravila naj se bolniki posvetujejo z zdravnikom, če imajo predvideno endoskopijo ali dihalni test s sečnino.
English: Esomeprazole is 97% plasma protein bound.
Slovenian: Esomeprazol se v 97 % veže na beljakovine v plazmi.
English: Esomeprazole is completely metabolised by the cytochrome P450 system (CYP).
Slovenian: Esomeprazol se povsem presnovi s sistemom citokroma P450 (CYP).
English: • Do not take more than this recommended dose of one tablet (20 mg) a day, even if you don't feel an improvement immediately.
Slovenian: • Ne vzemite večjega odmerka od priporočenega, ki je ena tableta (20 mg) na dan, tudi če ne čutite takoj izboljšanja.
English: Gastro-resistant tablet.
Slovenian: Gastrorezistentna tableta.
English: Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action.
Slovenian: Esomeprazol je S-izomer omeprazola in zmanjša izločanje želodčne kisline prek specifičnega mehanizma delovanja.
English: It is important not to damage the pellets.
Slovenian: Pomembno je, da se zrnca ne poškodujejo.
English: Pharmacotherapeutic group: Drugs for acid related disorders, proton pump inhibitors, ATC code: A02BC05.
Slovenian: Farmakoterapevtska skupina: zdravila za kislinsko pogojene bolezni, zaviralci protonske črpalke, oznaka ATC: A02BC05.
English: The slightly prolonged QTc interval observed after administration of cisapride alone, was not further prolonged when cisapride was given in combination with esomeprazole.
Slovenian: Rahlo podaljšanje intervala QTc, opaženo po uporabi samega cisaprida, se med sočasno uporabo cisaprida in esomeprazola ni dodatno povečalo.
English: • You get a rash on your skin, especially in areas exposed to the sun tell your doctor as soon as you can, as you may need to stop your treatment with Nexium Control.
Slovenian: • če se pojavi kožni izpuščaj, zlasti na koži, ki je izpostavljena soncu, čim prej obvestite zdravnika, saj boste morda morali prekiniti zdravljenje z zdravilom Nexium Control.
English: Your doctor may need to monitor you when you start or stop taking Nexium Control.
Slovenian: Zdravnik vas bo morda moral spremljati, ko boste začeli ali nehali jemati zdravilo Nexium Control.
English: The capsule has a yellow centre band, and contains yellow and purple enteric coated pellets.
Slovenian: Kapsula ima rumeno sredinsko črto in vsebuje rumena in vijolična zrnca z gastrorezistentno oblogo.
English: Elderly patients (≥65 years old) Dose adjustment is not required in elderly patients.
Slovenian: Starejši bolniki (stari 65 let ali več) Starejšim bolnikom odmerka ni treba prilagoditi.
English: Esomeprazole is extensively plasma protein bound and is therefore not readily dialysable.
Slovenian: Esomeprazol se v veliki meri vezže na beljakovine v plazmi in se zato ne dializira zlahka.
English: • If you are allergic to esomeprazole or any of the other ingredients of this medicine (listed in section 6).
Slovenian: - Če ste alergični na esomeprazol ali katerokoli sestavino tega zdravila (navedeno v poglavju 6).
English: • Do not take more than this recommended dose of one capsule (20 mg) a day, even if you don't feel an improvement immediately.
Slovenian: • Ne vzemite večjega odmerka od priporočenega, ki je ena kapsula (20 mg) na dan, tudi če ne čutite takoj izboljšanja.
English: Alternative method of taking this medicine
Slovenian: Drugi možni način jemanja tega zdravila
English: The parameters below reflect mainly the pharmacokinetics in individuals with a functional CYP2C19 enzyme, extensive metabolisers.
Slovenian: Spodaj navedeni parametri odražajo predvsem farmakokinetiko pri posameznikih s funkcionalnim encimom CYP2C19, tj. dobrih metabolizatorjih.
English: Total plasma clearance is about 17 l/h after a single dose and about 9 l/h after repeated administration.
Slovenian: Celotni plazemski očistek je približno 17 l/h po posamičnem odmerku in približno 9 l/h po večkratni uporabi.
English: These findings have no implications for the posology of esomeprazole.
Slovenian: Ti izsledki ne vplivajo na odmerjanje esomeprazola.
English: • If you are suffering from any of the side effects detailed in Section 4 which require medical attention.
Slovenian: • če imate katerekoli neželene učinke, opisane v poglavju 4, zaradi katerih morate poiskati zdravniško pomoč.
English: In healthy volunteers, concomitant administration of 40 mg esomeprazole resulted in a 32% increase in area under the plasma concentration-time curve (AUC) and a 31% prolongation of elimination half-life(t1/2) but no significant increase in peak plasma levels of cisapride.
Slovenian: Pri zdravih prostovoljcih je sočasna uporaba 40 mg esomeprazola povzročila 32 % povečanje površine pod krivuljo plazemske koncentracije po času (AUC) in 31 % podaljšanje eliminacijskega razpolovnega časa (t1/2), a brez pomembnega povečanja največje koncentracije cisaprida v plazmi.
English: Psychiatric disorders insomnia agitation, confusion, depression aggression, hallucinations
Slovenian: Psihiatrične motnje nespečnost agitiranost, zmedenost, depresija agresivnost, halucinacije
English: • Aggression
Slovenian: • napadalnost
English: If affected, patients should not drive or use machines.
Slovenian: Bolniki, pri katerih se pojavijo ti neželeni učinki, ne smejo voziti ali upravljati strojev.
English: • If you experience any of the symptoms detailed in Section 2 of this leaflet and it advises you to talk to your doctor or pharmacist.
Slovenian: • če se pojavijo katerikoli simptomi, opisani v poglavju 2 teh navodil za uporabo, in je navedeno, da se posvetujte z zdravnikom ali farmacevtom;
English: Do not take this medicine with other medicines that limit the amount of acid produced in your stomach such as proton pump inhibitors (e.g. pantoprazole, lansoprazole, rabeprazole or omeprazole) or an H2 antagonist (e.g. ranitidine or famotidine).
Slovenian: Ne jemljite tega zdravila z drugimi zdravili, ki zmanjšujejo nastajanje kisline v želodcu, npr. z zaviralcem protonske črpalke (na primer s pantoprazolom, lansoprazolom, rabeprazolom ali omeprazolom) ali antagonistom receptorjev H2 (na primer z ranitidinom, famotidinom).
English: Thus, when esomeprazole is combined with medicinal products metabolised by CYP2C19, such as warfarin, phenytoin, citalopram, imipramine, clomipramine, diazepam, etc., the plasma concentrations of these medicinal products may be increased and a dose reduction could be needed.
Slovenian: Če je torej esomeprazol uporabljen v kombinaciji z zdravili, ki se presnavljajo s CYP2C19, npr. z varfarinom, fenitoinom, citalopramom, imipraminom, klomipraminom, diazepamom itn., se lahko koncentracija teh zdravil v plazmi zviša in potrebno je lahko zmanjšanje odmerka.
English: lansoprazole, rabeprazole or omeprazole).
Slovenian: lansoprazol, rabeprazol ali omeprazol).
English: • Low numbers of red blood cells, white blood cells, and platelets (a condition called pancytopenia).
Slovenian: • majhno število rdečih krvnih celic, belih krvnih celic in krvnih ploščic (takšno stanje imenujemo pancitopenija)
English: • You are taking any medicines listed in the package leaflet.
Slovenian: • jemljete katerakoli zdravila, ki so navedena v navodilu za uporabo;
English: The absorption of medicinal products taken orally such as ketoconazole, itraconazole and erlotinib can decrease during treatment with esomeprazole and the absorption of digoxin can increase during treatment with esomeprazole.
Slovenian: Absorpcija peroralnih zdravil, kot so ketokonazol, itrakonazol in erlotinib, se lahko med zdravljenjem z esomeprazolom zmanjša, absorpcija digoksina pa se lahko med zdravljenjem z esomeprazolom poveča.
English: In two multicentre, randomised, double-blind, placebo-controlled pivotal studies 234 subjects with a recent history of frequent heartburn were treated with 20 mg esomeprazole for 4 weeks.
Slovenian: V dveh multicentričnih, randomiziranih, dvojno slepih, s placebom kontroliranih ključnih študijah je 234 preiskovancev z nedavno anamnezo pogoste zgage 4 tedne prejemalo 20 mg esomeprazola.
English: dry mouth stomatitis, gastrointestinal candidiasis microscopic colitis
Slovenian: suha usta stomatitis, gastrointestinalna kandidoza mikroskopski kolitis
English: Patients with long-term recurrent symptoms of indigestion or heartburn should see their doctor at regular intervals.
Slovenian: Bolniki, ki imajo dolgotrajne ponavljajoče se simptome težav z želodcem ali zgago, morajo hoditi na redne preglede k zdravniku.
English: For 20 mg esomeprazole the corresponding values are 50% and 68% respectively.
Slovenian: Za 20-mg odmerek esomeprazola sta ti vrednosti 50 % oz. 68 %.
English: The bottle also contains a sealed container with silica gel desiccant.
Slovenian: Plastenka vsebuje tudi zapečaten vsebnik s sušilom iz silikagela.
English: This medicinal product contains sugar spheres (sucrose).
Slovenian: To zdravilo vsebuje sladkorne kroglice (saharozo).
English: The remaining part is dependent on another specific isoform, CYP3A4, responsible for the formation of esomeprazole sulphone, the main metabolite in plasma.
Slovenian: Preostali del je odvisen od druge specifične izooblike, CYP3A4; CYP3A4 je odgovoren za tvorbo esomeprazolsulfona, glavnega presnovka esomeprazola v plazmi.