FrancophonIA/ELRC3.0 huggingface dataset:
English: Rare (may affect up to 1 in 1,000 people) - Radiation recall (a skin rash like severe sunburn) which can occur on skin that has previously been exposed to radiotherapy, from days to years after the radiation - Bullous conditions (blistering skin diseases)-including Stevens-Johnson syndrome and Toxic epidermal necrolysis
Danish: Sjælden (kan forekomme hos op til 1 ud af 1.000 patienter) - Radiation recall (et hududslæt, der ligner en alvorlig solskoldning), som kan opstå på hud, der tidligere har været udsat for strålebehandling, dage eller op til år efter strålebehandlingen - Bulløse tilstande (hudsygdomme med blæredannelser), inklusive Stevens-Johnson syndrom og toksisk epidermal nekrolyse.
English: Treatment with Pemetrexed Krka should be discontinued if a patient experiences any haematologic or non-haematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed.
Danish: Behandlingen med Pemetrexed Krka skal afbrydes, hvis patienten efter to dosisreduktioner oplever hæmatologisk eller ikke-hæmatologisk toksicitet af grad 3 eller 4 eller omgående, hvis der observeres neurotoksicitet af grad 3 eller 4.
English: - If you experience sudden breathlessness, intense chest pain or cough with bloody sputum (uncommon) (may indicate a blood clot in the blood vessels of the lungs).
Danish: - Hvis du pludselig får åndenød, stærke smerter i brystet eller hoste med blodigt spyt (ikke almindeligt) (dette kan betyde, at der er en blodprop i en af lungernes blodårer).
English: Pemetrexed Krka is available in transparent glass vials containing either 100 mg or 500 mg pemetrexed.
Danish: Pemetrexed Krka får i gennemsigtige hætteglas (af glas), som indeholder enten 100 mg eller 500 mg pemetrexed.
English: Not known: frequency cannot be estimated from the available data - Lower limb swelling with pain and redness - Increased urine output - Thirst and increased water consumption - Hypernatraemia - increased sodium in blood - Inflammation of the skin, mainly of the lower limb with swelling, pain and redness
Danish: Ikke kendt: hyppigheden kan ikke vurderes ud fra forhåndenværende data - Hævelse i de nedre lemmer med smerte og rødme - Øget urinproduktion - Tørst og øget vandforbrug - Øget koncentration af natrium i blodet (hypernatriæmi) - Betændelse i huden, hovedsagligt i underbenet med hævelse, smerte og rødme
English: Stomatitis/Pharyngitis Diarrhoea without colostomy
Danish: Stomatitis/pharyngitis Diarré uden kolostomi Almindelig Dyspepsi/halsbrand
English: Efficacy of pemetrexed vs. docetaxel in NSCLC - ITT population
Danish: Effekt af pemetrexed versus docetaxel mod NSCLC - ITT-population
English: Clinically relevant Grade 3 and Grade 4 laboratory toxicities were similar between integrated Phase 2 results from three single-agent pemetrexed studies (N=164) and the Phase 3 single-agent pemetrexed study described above, with the exception of neutropenia (12.8% versus 5.3%, respectively) and alanine aminotransferase elevation (15.2% versus 1.9%, respectively).
Danish: De klinisk relevante laboratorierelaterede toksiciteter af grad 3 og 4 var ensartede mellem de integrerede fase 2-resultater fra tre studier med pemetrexed som enkeltstofbehandling (n = 164) og det fase 3-enkeltstofstudie med pemetrexed, som er beskrevet ovenfor, med undtagelse af neutropeni (12,8 % versus 5,3 %) og forhøjet alaninaminotransferase (15,2 % versus 1,9 %).
English: Creatinine elevation Creatinine clearance decreased**
Danish: Forhøjet kreatininniveau Nedsat kreatininclearance**
English: What you need to know before you use Pemetrexed Krka
Danish: Det skal du vide, før du begynder at bruge Pemetrexed Krka
English: 100% of previous dose a
Danish: 100 % af tidligere dosis a
English: Pemetrexed Krka contains sodium
Danish: Pemetrexed Krka indeholder natrium
English: What Pemetrexed Krka contains - The active substance is pemetrexed.
Danish: Pemetrexed Krka indeholder: - Aktivt stof: Pemetrexed.
English: Stomatitis/Pharyngitis Nausea
Danish: Stomatitis/pharyngitis Kvalme
English: - If you experience tiredness, feeling faint, becoming easily breathless or if you look pale (since you might have less haemoglobin than normal which is very common).
Danish: - Hvis du føler træthed, svimmelhed, hurtigt mister vejret, eller hvis du er bleg (fordi du muligvis har mindre hæmoglobin end normalt, hvilket er meget almindeligt).
English: Common Rash/desquamation 8.1
Danish: Almindelig Udslæt/hudafskalning 8,1
English: 3 and platelet count returns to ≥ 100,000 cells/mm
Danish: 3, og trombocyt tallet igen er  100.000 celler/mm
English: If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), Pemetrexed Krka should be withheld until resolution to less than or equal to the patient's pre-therapy value.
Danish: Hvis patienter udvikler ikke-hæmatologisk toksicitet  grad 3 (undtagen neurotoksicitet), skal behandlingen med Pemetrexed Krka seponeres, indtil patientens værdier er nået ned på eller under niveauet fra før behandlingen.
English: There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore, the use of pemetrexed is not recommended (see section 4.4).
Danish: Der foreligger ikke tilstrækkelige data om anvendelse af pemetrexed til patienter med en kreatinin-clearance under 45 ml/min, og pemetrexed anbefales derfor ikke til disse patienter (se pkt.
English: Pemetrexed Krka 500 mg powder for concentrate for solution for infusion This medicinal product contains 54 mg sodium per vial, equivalent to 2.7% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Danish: Pemetrexed Krka 500 mg pulver til koncentrat til infusionsvæske, opløsning Dette lægemiddel indeholder ca. 54 mg natrium pr. hætteglas, svarende til 2,7 % af den WHO anbefalede maximale daglige indtagelse af 2 g natrium for en voksen.
English: - If you experience bleeding from the gums, nose or mouth or any bleeding that would not stop, reddish or pinkish urine, unexpected bruising (since you might have less platelets than normal which is very common).
Danish: - Hvis du bløder fra gummer, næse eller mund eller anden blødning, som ikke vil stoppe, rødlig eller lyserødlig urin, uventede blå mærker (fordi du muligvis har færre blodplader end normalt, hvilket er meget almindeligt).
English: Pemetrexed solutions are for single use only.
Danish: Pemetrexed-opløsninger er kun beregnet til engangsbrug.
English: Pemetrexed Krka (pemetrexed) is a multi-targeted anti-cancer antifolate agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication.
Danish: Pemetrexed Krka (pemetrexed) er et bredspektret anti-cancer-antifolat, som virker ved at forstyrre de centrale folatafhængige metaboliske processer, der er afgørende for celledannelsen.
English: 75% of previous dose (both Pemetrexed Krka and cisplatin)
Danish: 75 % af tidligere dosis (både Pemetrexed Krka og cisplatin)
English: Pemetrexed Krka 500 mg contains 54 mg sodium (main component of cooking/table salt) per vial.
Danish: Pemetrexed Krka 500 mg indeholder 54 mg natrium (hovedkomponenten af madlavnings-/bordsalt) pr. hætteglas.
English: 50% of previous dose (both Pemetrexed Krka and cisplatin)
Danish: 50 % af tidligere dosis (både Pemetrexed Krka og cisplatin)
English: If a pemetrexed solution contacts the skin, wash the skin immediately and thoroughly with soap and water.
Danish: Hvis pemetrexed-opløsning kommer i kontakt med huden, skal det berørte område straks vaskes grundigt med vand og sæbe.
English: Neuropathy- sensory
Danish: Sensorisk neuropati
English: Each 100 mg vial contains an excess of pemetrexed to facilitate delivery of the label amount.
Danish: Hvert 100 mg hætteglas indeholder tilstrækkeligt pemetrexed til at indgive den angivne mængde.
English: Excipients: mannitol, hydrochloric acid, sodium hydroxide (E524).
Danish: Hjælpestoffer: mannitol, saltsyre, natriumhydroxid (E524).
English: Concomitant administration of nephrotoxic drugs (e.g., aminoglycoside, loop diuretics, platinum compounds, cyclosporin) could potentially result in delayed clearance of pemetrexed.
Danish: Samtidig behandling med nefrotoksiske lægemidler (f.eks. aminoglycosid, loop-diuretika, platinforbindelser, ciclosporin) kan resultere i forsinket clearance af pemetrexed.
English: Hydrochloric acid (for pH adjustment) Sodium hydroxide (for pH adjustment) (E524)
Danish: Saltsyre (til justering af pH) Natriumhydroxid (til justering af pH) (E524)
English: - The other ingredients are mannitol, hydrochloric acid (for pH adjustment), sodium hydroxide (for pH adjustment) (E524).
Danish: - Øvrige indholdsstoffer: Mannitol, saltsyre (til justering af pH), natriumhydroxid (til justering af pH) (E524).
English: A hospital pharmacist, nurse or doctor will have mixed the Pemetrexed Krka powder with 9 mg/ml (0.9%) sodium chloride solution for injection before it is given to you.
Danish: Hospitalsapoteket, sygeplejersken eller lægen blander på forhånd Pemetrexed Krka-pulveret med natriumchlorid-injektionsvæske 9 mg/ml (0,9%), før det indgives til dig.
English: Pemetrexed at a dose of 500 mg/m2 was studied as a single agent in 64 chemonaive patients with malignant pleural mesothelioma.
Danish: Pemetrexed i en dosis på 500 mg/m2 blev undersøgt som enkeltstofbehandling til 64 patienter med malignt pleuramesoteliom, som ikke tidligere havde modtaget kemoterapi.
English: Nadir platelets < 50,000/mm regardless of nadir
Danish: Nadir for trombocytter < 50.000/mm uanset
English: Nadir ANC < 500/mm 3 and nadir platelets
Danish: ANC-nadir < 500 /mm
English: In patients with normal renal function (creatinine clearance ≥ 80 ml/min), high doses of non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen > 1600 mg/day) and acetylsalicylic acid at higher doses (≥ 1.3 g daily) may decrease pemetrexed elimination and, consequently, increase the occurrence of pemetrexed adverse events.
Danish: Hos patienter med en normal nyrefunktion (kreatinin-clearance 80 ml/min) kan høje doser af nonsteroide anti-inflammatoriske lægemidler (NSAID-præparater såsom ibuprofen > 1.600 mg/dag) og acetylsalicylsyre i høje doser ( 1,3 g daglig) nedsætte udskillelsen af pemetrexed, og dermed øge forekomsten af bivirkninger relateret til pemetrexed.
English: Sepsis, sometimes fatal, has been commonly reported during clinical trials with pemetrexed.
Danish: Sepsis, sommetider dødelig, blev rapporteret med frekvensen ”almindelig” under kliniske studier med pemetrexed.
English: • Response rate (%) (95% CI)
Danish: • Responsrate (%) (95 % CI)
English: Patients also required lower administration of erythropoietin/darbopoietin (10.4% versus 18.1%, p < 0.001), G-CSF/GM-CSF (3.1% versus 6.1%, p=0.004), and iron preparations (4.3% versus 7.0%, p=0.021).
Danish: Patienterne behøvede ligeledes mindre erythropoietin/darbopoietin (10,4 % mod 18,1 %, p<0,001), G-CSF/GM-CSF (3,1 % mod 6,1 %; p = 0,004) og midler med jern (4,3 % mod 7,0 %; p = 0,021).
English: Neutrophils/Granulocytes decreased
Danish: Nedsat neutrofiler/ granulocytter
English: In clinical trials, cases of colitis (including intestinal and rectal bleeding, sometimes fatal, intestinal perforation, intestinal necrosis and typhlitis) have been reported uncommonly in patients treated with pemetrexed.
Danish: Tilfælde af colitis (inklusive intestinal og rektal blødning, sommetider dødelig, intestinal nekrose og typhlitis) er ikke almindeligt rapporteret hos patienter behandlet med pemetrexed i kliniske studier.
English: There is no relevant use of Pemetrexed Krka in the paediatric population in malignant pleural mesothelioma and non-small cell lung cancer.
Danish: Det er ikke relevant at bruge Pemetrexed Krka til malignt pleuramesoteliom og ikke-småcellet lungecancer i den pædiatriske population.
English: Large Cell Carcinoma
Danish: Lame Cell Cardnonia
English: Progression-free survival (PFS) and overall response rate were similar between treatment arms: median PFS was 4.8 months for pemetrexed plus cisplatin versus 5.1 months for gemcitabine plus cisplatin (adjusted hazard ratio (HR) 1.04; 95% CI=0.94-1.15), and overall response rate was 30.6% (95% CI=27.3- 33.9) for pemetrexed plus cisplatin versus 28.2% (95% CI=25.0-31.4) for gemcitabine plus cisplatin.
Danish: Progressionsfri overlevelse (PFS) og størrelsen af det totale respons var ens mellem de to behandlingsarme: Middel PFS var 4,8 måneder for pemetrexed plus cisplatin mod 5,1 måneder for gemcitabin plus cisplatin (justeret hazard ratio (HR) 1.04; 95 % CI = 0,94-1,15) og det totale respons var 30,6 % (95 % CI = 27,3-33,9) for pemetrexed plus cisplatin mod 28,2 % (95 % CI = 25,0-31,4) for gemcitabin plus cisplatin.
English: Pemetrexed total systemic clearance is 91.8 ml/min and the elimination half-life from plasma is 3.5 hours in patients with normal renal function (creatinine clearance of 90 ml/min).
Danish: Pemetrexeds samlede systemiske clearance er 91,8 ml/min, og halveringstiden i plasma er 3,5 timer
English: Pemetrexed Krka 100 mg contains less than 1 mmol sodium (23 mg) per vial, that is to say essentially “sodium-free”.
Danish: Pemetrexed Krka 100 mg indeholder mindre end 1 mmol (23 mg) natrium pr. hætteglas, dvs. den er i det væsentlige natrium-fri.
English: Patients treated with pemetrexed and cisplatin required fewer transfusions (16.4% versus 28.9%, p < 0.001), red blood cell transfusions (16.1% versus 27.3%, p < 0.001) and platelet transfusions (1.8% versus 4.5%, p=0.002).
Danish: Patienter, der blev behandlet med pemetrexed og cisplatin, havde brug for færre transfusioner (16,4 % mod 28,9 %; p<0,001), transfusioner af røde blodlegemer (16,1 % mod 27,3 %; p<0,001) og blodpladetransfusioner (1,8 % mod 4,2 %; p = 0,002).
English: Excipient with known effect Each vial contains approximately 11 mg (0.48 mmol) sodium.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hvert hætteglas indeholder ca. 11 mg (0,48 mmol) natrium.
English: Women must use effective contraception during treatment with Pemetrexed Krka.
Danish: Kvinder skal anvende effektive svangerskabsforebyggende midler under behandlingen med Pemetrexed Krka.
English: Gemcitabine/ Cisplatin (N=830)
Danish: Gemcitabin/ cisplatin (n = 830)
English: During the study, low-dose folic acid and vitamin B12 supplementation was introduced to patients' therapy to reduce toxicity.
Danish: I løbet af studiet blev patienternes behandling suppleret med et lavdosistilskud af folsyre og B12-vitamin for at mindske toksiciteten.
English: Excipient with known effect Each vial contains approximately 54 mg (2.35 mmol) sodium.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hvert hætteglas indeholder ca. 54 mg (2,35 mmol) natrium.
English: Pemetrexed Krka is given in combination with cisplatin, another anti-cancer medicine, as treatment for malignant pleural mesothelioma, a form of cancer that affects the lining of the lung, to patients who have not received prior chemotherapy.
Danish: Pemetrexed Krka anvendes sammen med cisplatin, en anden medicin mod kræft, til behandling af malignt pleuramesoteliom, en kræftform som påvirker lungehinderne, til patienter, som ikke tidligere har fået kemoterapi.
English: The table below provides the frequency and severity of undesirable effects that have been reported in >5% of 168 patients with mesothelioma who were randomised to receive cisplatin and pemetrexed, and 163 patients with mesothelioma randomised to receive single-agent cisplatin.
Danish: Nedenstående tabel viser hyppigheden og sværhedsgraden af bivirkninger, der blev rapporteret hos >5 % af 168 patienter med mesoteliom, som var randomiseret til behandling med cisplatin og pemetrexed, og 163 patienter med mesoteliom, som var randomiseret til enkeltstofbehandling med cisplatin.
English: A multi-centre, randomised, open-label Phase 3 study of pemetrexed versus docetaxel in patients with locally advanced or metastatic NSCLC after prior chemotherapy has shown median survival times of 8.3 months for patients treated with pemetrexed (Intent-To-Treat [ITT] population N=283) and 7.9 months for patients treated with docetaxel (ITT N=288).
Danish: Et åbent, randomiseret fase 3-multicenterstudie med pemetrexed versus docetaxel til patienter med lokalt fremskreden eller metastatisk NSCLC (ikke-småcellet lungekræft), der tidligere var behandlet med kemoterapi, har vist en median-overlevelsestid på 8,3 måneder for patienter, som blev behandlet med pemetrexed (intent-to-treat-population n = 283), og 7,9 måneder for patienter, som blev behandlet med docetaxel (ITT n = 288).
English: Please tell your doctor or hospital pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Danish: Fortæl det altid til lægen eller hospitalsapoteket, hvis du bruger anden medicin eller har gjort det for nylig.
English: Nadir platelets < 50,000/mm 3 with bleeding a,
Danish: Nadir for trombocytter < 50.000/mm 3 med blødning a uanset ANC-nadir
English: Children and adolescents There is no relevant use of Pemetrexed Krka in the paediatric population
Danish: Børn og unge Det er ikke relevant at bruge Pemetrexed Krka til børn og unge.
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1000 micrograms) that you must take once a day while you are taking Pemetrexed Krka.
Danish: Vitamintilskud: Du skal tage en folsyretablet eller en multivitamin indeholdende folsyre (3501000 mikrogram) 1 gang dagligt, mens du tager Pemetrexed Krka.
English: Breast-feeding must be discontinued during Pemetrexed Krka treatment.
Danish: Amningen skal afbrydes under behandling med Pemetrexed Krka.
English: In patients treated for non-small cell lung cancer after prior chemotherapy, the recommended dose of Pemetrexed Krka is 500 mg/m2 BSA administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Danish: Til patienter, der behandles for ikke-småcellet lungecancer efter tidligere behandling med kemoterapi, er den anbefalede dosis af Pemetrexed Krka 500 mg/m2 legemesoverflade indgivet som intravenøs infusion over 10 minutter på den første dag i hver 21-dages-serie.
English: A multi-centre, randomised, open-label, Phase 3 study of pemetrexed plus cisplatin versus gemcitabine plus cisplatin in chemonaive patients with locally advanced or metastatic (Stage IIIb or IV) non-small cell lung cancer (NSCLC) showed that pemetrexed plus cisplatin (Intent-To-Treat [ITT] population N=862) met its primary endpoint and showed similar clinical efficacy as gemcitabine plus cisplatin (ITT N=863) in overall survival (adjusted hazard ratio (HR) 0.94; 95% CI=0.84-1.05).
Danish: Et randomiseret, åbent, fase 3-multicenterstudie af pemetrexed plus cisplatin mod gemcitabin plus cisplatin med patienter, der ikke tidligere har fået kemoterapi, med lokalt fremskreden eller metastatisk (fase IIIb eller IV) ikke-småcellet lungecancer (NSCLC) viste, at pemetrexed plus cisplatin (Intent-To-Treat [ITT] population n = 862) mødte dets primære endepunkt og viste lignende klinisk virkning som gemcitabin plus cisplatin (ITT n = 863) på total overlevelse (justeret hazard ratio (HR) 0,94; 95 % CI = 0,84-1,05).
English: Table 2 - Dose modification table for Pemetrexed Krka (as single agent or in combination) and cisplatin - Non-haematologic toxicities a, b
Danish: Tabel 2 - Dosisjustering for Pemetrexed Krka (som enkeltstof eller i kombination) og cisplatin - ikke-hæmatologisk toksicitet a, b
English: Very common (may affect more than 1 in 10 people) - Low white blood cells - Low haemoglobin level (anaemia) - Low platelet count - Diarrhoea - Vomiting - Pain, redness, swelling or sores in your mouth - Nausea - Loss of appetite - Fatigue (tiredness) - Skin rash - Hair loss - Constipation - Loss of sensation - Kidney: abnormal blood tests
Danish: Meget almindelig (kan forekomme hos flere end 1 ud af 10 patienter) - Lavt antal hvide blodlegemer - Lavt hæmoglobin niveau (anæmi) - Lavt antal blodplader - Diarré - Opkastning - Smerter, rødmen, hævelse eller sår i munden - Kvalme - Appetitløshed - Træthed - Udslæt - Hårtab - Forstoppelse - Nedsat føleevne - Nyrer: abnorme blodprøveresultater
English: Nervous system disorders
Danish: Nervesystemet Meget almindelig
English: Pemetrexed + Cisplatin Gemcitabine + Cisplatin
Danish: Pemetrexed + Cisplatin
English: Oesophagitis/radiation oesophagitis has been uncommonly reported during clinical trials with pemetrexed:
Danish: Øsophagitis/ strålings-øsophagitis er ikke almindeligt rapporteret under kliniske studier med pemetrexed.
English: PARAMOUNT: Kaplan-Meier plot of progression-free survival (PFS) and Overall Survival (OS) for continuation pemetrexed maintenance versus placebo in patients with NSCLC other than predominantly squamous cell histology (measured from randomisation)
Danish: PARAMOUNT: Kaplan Meier-kurver for progressionsfri overlevelse (PFS) og total overlevelse (OS, overall survival) for pemetrexed-induktionsbehandling efterfulgt af pemetrexedvedligeholdelsesbehandling versus placebo hos patienter med NSCLC bortset fra cancer hovedsagelig bestående af pladeepitelceller (målt fra randomiseringen)
English: Therefore, the use of pemetrexed in patients with creatinine clearance of <45 ml/min is not recommended (see section 4.2).
Danish: Pemetrexed anbefales derfor ikke til patienter med en kreatinin-clearance på < 45 ml/min (se pkt.
English: An analysis of the impact of NSCLC histology on the treatment effect on overall survival was in favour of pemetrexed versus docetaxel for other than predominantly squamous histologies (N=399, 9.3 versus 8.0 months, adjusted hazard ratio (HR) = 0.78; 95% CI=0.61-1.00, p=0.047) and was in favour of docetaxel for squamous cell carcinoma histology (N=172, 6.2 versus 7.4 months, adjusted HR=1.56; 95% CI=1.08-2.26, p=0.018).
Danish: En analyse af virkningen på NSCLCs histologi for behandlingens virkning på overlevelse var til fordel for pemetrexed versus docetaxel bortset fra cancerformer hovedsageligt bestående af pladeepitelceller (n = 399; 9,3 versus 8,0 måneder, justeret HR = 0,78; 95 % CI = 0,61-1,00; p = 0,047) og til fordel for docetaxel for carcinom af pladeepitelceller (n = 172; 6,2 versus 7,4 måneder, justeret HR = 1,56; 95 % CI = 1,08-2,26; p = 0,018).
English: Pemetrexed Krka is also a treatment for patients with advanced stage of lung cancer whose disease has progressed after other initial chemotherapy has been used.
Danish: Pemetrexed Krka er også en behandling til patienter med fremskreden lungekræft, hvor sygdommen har udviklet sig, efter anden indledende behandling med kemoterapi har været forsøgt.
English: In the absence of data regarding potential interaction with NSAIDs having longer half-lives such as piroxicam or rofecoxib, the concomitant administration with pemetrexed in patients with mild to moderate renal insufficiency should be interrupted for at least 5 days prior to, on the day of, and at least 2 days following pemetrexed administration (see section 4.4).
Danish: Da der ikke foreligger data om potentielle interaktioner mellem pemetrexed og NSAID-præparater med længere halveringstid, såsom piroxicam eller rofecoxib, skal behandling med disse afbrydes hos patienter med let til moderat nyreinsufficiens mindst 5 dage før, på behandlingsdagen og i mindst 2 dage efter indgift af pemetrexed (se pkt.
English: Pemetrexed Krka 100 mg powder for concentrate for solution for infusion This medicinal product contains less than 1 mmol sodium (23 mg) per vial, that is to say essentially “sodium-free”.
Danish: Pemetrexed Krka 100 mg pulver til koncentrat til infusionsvæske, opløsning Dette lægemiddel indeholder mindre en 1 mmol (23 mg) natrium pr. hætteglas, dvs. den er i det væsentlige natrium-fri.