FrancophonIA/ELRC3.0 huggingface dataset:
English: Your doctor will stop Votrient at least 7 days before your operation as it may affect wound healing.
Croatian: Liječnik će Vam prestati davati Votrient najmanje 7 dana prije operacije jer može utjecati na zacjeljivanje rane.
English: This can result in a very fast heartbeat causing a sudden loss of consciousness.
Croatian: Posljedica toga je vrlo brz srčani ritam koji može uzrokovati iznenadan gubitak svijesti.
English: Votrient can also affect how some other medicines work.
Croatian: Votrient također može utjecati na djelovanje nekih drugih lijekova.
English: Don't stop unless your doctor advises you to.
Croatian: Nemojte prestati ako Vam liječnik nije tako preporučio.
English: The dose of pazopanib should not exceed 800 mg.
Croatian: Doza pazopaniba ne bi smjela prijeći 800 mg.
English: While observed in both RCC and STS studies, the incidence was higher in the STS population (5%) than in the RCC population (2%).
Croatian: Iako zabilježeni i u ispitivanjima RCC-a i STS-a, incidencija je bila viša u populaciji sa STS-om (5%) nego u populaciji s RCC-om (2%).
English: Based on the rodent-specific pathogenesis and mechanism for these findings, they are not considered to represent an increased carcinogenic risk for patients taking pazopanib.
Croatian: Temeljeno na specifičnoj patogenezi u glodavaca i mehanizmu ovih nalaza, ne smatra se da predstavljaju povećani rizik kancerogenosti za bolesnike koji uzimaju pazopanib.
English: Overall efficacy results are summarised in Table 5.
Croatian: Ukupni rezultati djelotvornosti sažeto su prikazani u tablici 5.
English: Symptoms include shortness of breath or cough that will not go away.
Croatian: Simptomi uključuju nedostatak zraka ili kašalj koji ne prolazi.
English: The 200 mg tablets also contain iron oxide red (E172).
Croatian: Tablete od 200 mg također sadrže i crveni željezov oksid (E172).
English: The following tumour types were eligible:
Croatian: Sljedeći tipovi tumora su bili pogodni:
English: These could be signs of a blood clot in your body (thromboembolism).
Croatian: Ovo mogu biti znakovi krvnih ugrušaka u Vašem tijelu (tromboembolija).
English: However, the UGT1A1 genotype was not always predictive of the effect of pazopanib on SN-38 disposition.
Croatian: Međutim, UGT1A1 genotip nije uvijek prediktivan za učinak pazopaniba na SN-38 dispoziciju.
English: Hypertensive crisis (sudden and severe rise in blood pressure) Votrient can on occasion cause a sudden and severe rise in blood pressure.
Croatian: Hipertenzivna kriza (iznenadno i jako povećanje krvnog tlaka) Votrient ponekad može uzrokovati iznenadno i jako povećanje krvnog tlaka.
English: Possible side effects (including possible serious side effects under the relevant frequency category).
Croatian: Moguće nuspojave (uključujući moguće ozbiljne nuspojave pod odgovarajućom skupinom učestalosti).
English: Combination with other systemic anti-cancer therapies
Croatian: Kombinacija s drugim sistemskim antitumorskim terapijama
English: Cases of serious infections (with or without neutropenia), in some cases with fatal outcome, have been reported.
Croatian: Prijavljeni su slučajevi ozbiljnih infekcija (s ili bez neutropenije), u nekim slučajevima s fatalnim ishodom.
English: There is no specific antidote for overdose with pazopanib and treatment of overdose should consist of general supportive measures.
Croatian: Ne postoji specifični antidot za predoziranje pazopanibom i terapija predoziranja treba se sastojati od općih suportivnih mjera.
English: Votrient is a type of medicine called a protein kinase inhibitor.
Croatian: Votrient spada u grupu lijekova koje nazivamo inhibitorima protein kinaze.
English: Patients should be monitored for hypertension early after starting treatment (no longer than one week after starting pazopanib) and frequently thereafter to ensure blood pressure control.
Croatian: Bolesnike treba pratiti zbog hipertenzije ubrzo nakon početka liječenja (ne dulje od tjedan dana od početka liječenja pazopanibom) i nakon toga učestalo kako bi se osigurala kontrola krvnog tlaka.
English: Glaxo Operations UK Ltd (trading as Glaxo Wellcome Operations) Priory Street
Croatian: Glaxo Operations UK Ltd (posluje kao Glaxo Wellcome Operations) Priory Street
English: Pazopanib is not indicated for use in combination with other agents.
Croatian: Pazopanib nije indiciran za uporabu u kombinaciji s drugim tvarima.
English: Pazopanib is eliminated slowly with a mean half-life of 30.9 hours after administration of the recommended dose of 800 mg.
Croatian: Pazopanib se sporo eliminira s prosječnim poluvijekom od 30,9 sati nakon uzimanja preporučene doze od 800 mg.
English: Extremadura, 3, 09400 Aranda De Duero, Burgos, Spain Novartis Pharmaceuticals UK Limited, Frimley Business Park, Frimley, Camberley, Surrey GU16 7SR, United Kingdom
Croatian: Extremadure 3, 09400 Aranda de Duero, Burgos, Španjolska Novartis Pharmaceuticals UK Limited, Frimley Business Park, Frimley, Camberley, Surrey GU16 7SR, Ujedinjeno Kraljevstvo
English: Categories have been assigned based on absolute frequencies in the clinical trial data.
Croatian: Kategorije su dodijeljene ovisno o apsolutnim učestalostima u podacima kliničkih ispitivanja.
English: Pazopanib has not been studied in patients who have had an event within the previous 6 months.
Croatian: Pazopanib nije ispitivan u bolesnika koji su imali događaj unutar prethodnih 6 mjeseci.
English: Your treatment will be restarted when the wound has adequately healed.
Croatian: Nastavit ćete sa terapijom nakon što rana dovoljno zacijeli.
English: For example, you could take it two hours after breakfast or one hour before lunch.
Croatian: Na primjer, možete ga uzeti dva sata nakon doručka ili jedan sat prije ručka.
English: The primary objective of this study was to evaluate and compare PFS in patients treated with pazopanib to those treated with sunitinib.
Croatian: Primarni cilj tog ispitivanja bio je procijeniti i usporediti PFS bolesnika koji su primali pazopanib u odnosu na one koji su primali sunitinib.
English: 99% of patients (243/246) enrolled in the STS Phase III study, including the 15 subjects, received anthracycline.
Croatian: 99% bolesnika (243/246) uključenih u ispitivanje STS-a faze III, uključujući onih 15 ispitanika, primalo je antracikline.
English: The recommendations for how PPIs and H2-receptor antagonists are co-administered are based on physiological considerations.
Croatian: Preporuke kako istodobno primijeniti IPP i antagoniste H2 receptora temelje se na fiziološkim karakteristikama.
English: Votrient can lower the amount of thyroid hormone produced in your body.
Croatian: Votrient može sniziti količinu hormona štitnjače koju Vaše tijelo proizvodi.
English: If the clot breaks off, it may travel to your lungs and this may be life threatening or even fatal.
Croatian: Ako se ugrušak otkine, mogao bi stići do pluća, a to može biti životno ugrožavajuće ili čak smrtonosno.
English: This can result in blurry or impaired vision.
Croatian: To može rezultirati zamagljenim ili oslabljenim vidom.
English: “Other STS” subgroups*
Croatian: „Ostale STS“ podgrupe*
English: Demographic characteristics were similar between the treatment arms.
Croatian: Demografske karakteristike oba terapijska kraka bile su slične.
English: Results indicate that less than 4% of an orally administered pazopanib dose is excreted in the urine as pazopanib and metabolites.
Croatian: Rezultati ukazuju da se manje od 4% peroralno primijenjene doze pazopaniba izlučuje urinom kao pazopanib i metaboliti.
English: P value = 0.245 (2-sided)
Croatian: P vrijednost = 0,245 (dvostrano)
English: Tell your doctor if any of these apply to you.
Croatian: Recite svom liječniku ako se bilo što od ovoga odnosi na Vas.
English: Importantly, only patients with selective histological subtypes of STS were allowed to participate to the study, therefore efficacy and safety of pazopanib can only be considered established for those subgroups of STS and treatment with pazopanib should be restricted to such STS subtypes.
Croatian: Važno je da su samo bolesnici s odabranim histološkim podtipovima STS-a mogli sudjelovati u ispitivanju, stoga, djelotvornost i sigurnost primjene pazopaniba može biti utvrđena za te podgrupe STS-a, a liječenje pazopanibom bi trebalo biti ograničeno na te STS podtipove.
English: Table 5 Overall efficacy results (VEG108844)
Croatian: Tablica 5 Ukupni rezultati djelotvornosti (VEG108844)
English: Daily dosing results in 1.23- to 4-fold increase in AUC0-T.
Croatian: Dnevno doziranje rezultira povećanjem AUC0-T od 1,23 do 4 puta.
English: Seek medical help immediately if you get any of these symptoms.
Croatian: Odmah potražite liječničku pomoć u slučaju pojave bilo kojega od navedenih simptoma.
English: - if you have had stomach or bowel problems such as perforation (hole) or fistula (abnormal passages forming between parts of the intestine).
Croatian: - ako ste imali tegobe sa želucem ili crijevima poput perforacije (rupe) ili fistule (abnormalni prolazi koji se stvaraju između dijelova crijeva).
English: Binding of pazopanib to human plasma protein in vivo was greater than 99% with no concentration dependence over the range of 10-100 g/ml.
Croatian: Vezanje pazopaniba za protein u ljudskoj plazmi in vivo bilo je veće od 99%, neovisno o koncentraciji u rasponu od 10-100 g/ml.
English: In this dataset, 133/2235 (6%) of the patients carried the HLA-B*57:01 allele (see section 4.4).
Croatian: U ovom skupu podataka, 133/2235 (6%) bolesnika nosilo je alel HLA-B*57:01 (vidjeti dio 4.4).
English: P value (one-sided)
Croatian: P vrijednost (jednostrano)
English: - if you have had problems with bleeding, blood clots or narrowing of the arteries
Croatian: - ako ste imali problema s krvarenjem, krvnim ugrušcima i suženjem arterija.
English: The type of medicine that you are taking to reduce your stomach acid (e.g. proton pump inhibitor, H2 antagonists or antacids) may affect how Votrient is taken.
Croatian: Vrsta lijeka kojeg uzimate kako bi smanjili želučanu kiselinu (npr. inhibitori protonske pumpe, H2 antagonisti ili antacidi) može utjecati na uzimanje lijeka Votrient.
English: For patients who responded to treatment, the median time to response was 11.9 weeks and the median duration of response was 58.7 weeks as per independent review (VEG105192).
Croatian: Prema neovisnoj procjeni, za bolesnike koji su odgovorili na liječenje, medijan vremena do odgovora bio je 11,9 tjedana, a medijan trajanja odgovora bio je 58,7 tjedana (VEG105192).
English: In the majority of the cases, isolated increases in ALT and AST have been reported, without concomitant elevations of alkaline phosphatase or bilirubin.
Croatian: U većini slučajeva radilo se o izoliranom porastu vrijednosti ALT-a i AST-a, bez istovremenog porasta vrijednosti alkalne fosfataze ili bilirubina.
English: Efficacy and safety has only been established in certain STS histological tumour subtypes (see section 5.1).
Croatian: Djelotvornost i sigurnost su ustanovljene samo za određene histološke podtipove STS tumora (vidjeti dio 5.1).
English: The four principle pazopanib metabolites account for only 6% of the exposure in plasma.
Croatian: Četiri glavna metabolita pazopaniba zaslužna su za samo 6% izloženosti u plazmi.
English: Male patients (including those who have had vasectomies) who have partners who are either pregnant or who could become pregnant (including those who use other methods of contraception) should use condoms during sexual intercourse while taking Votrient and for at least 2 weeks after the last dose.
Croatian: Muški bolesnici (uključujući one koji su imali vazektomiju) čije su partnerice ili trudne ili mogu zatrudnjeti (uključujući one koji koriste druge metode kontracepcije) trebaju koristiti prezervative tijekom spolnog odnosa dok uzimaju Votrient i najmanje 2 tjedna nakon posljednje doze.
English: Within each system organ class, adverse reactions with the same frequency are presented in order of decreasing seriousness.
Croatian: U svakoj klasi organskog sustava nuspojave iste učestalosti su predstavljene u padajućem nizu prema ozbiljnosti.
English: Table 3 Treatment-related adverse reactions reported in STS studies (n=382)
Croatian: Tablica 3: Nuspojave povezane s liječenjem prijavljene u ispitivanjima STS-a (n=382)
English: The OS results are subject to potential bias as 54% of patients in the placebo arm also received pazopanib in the extension part of this study following disease progression.
Croatian: Postoji potencijalna pristranost za OS rezultate jer je 54% bolesnika iz placebo skupine također primalo pazopanib u produžetku ove studije kojom se pratila progresija bolesti.
English: Possible serious side effects
Croatian: Moguće ozbiljne nuspojave
English: There are limited data on the use of pazopanib in patients aged 65 years and older.
Croatian: Postoje ograničeni podaci o primjeni pazopaniba u bolesnika starijih od 65 godina.
English: Pazopanib should not be used during pregnancy unless the clinical condition of the woman requires treatment with pazopanib.
Croatian: Pazopanib se ne bi smio primjenjivati tijekom trudnoće, osim ako kliničko stanje žene ne zahtijeva liječenje pazopanibom.
English: - certain forms of soft-tissue sarcoma, which is a type of cancer that affects the supportive tissues of the body.
Croatian: - određenih oblika sarkoma mekih tkiva, vrste raka koja zahvaća potporna tkiva u tijelu.
English: Patients who carry the HLA-B*57:01 allele have an increased risk of pazopanib-associated ALT elevations.
Croatian: Bolesnici koji nose alel HLA-B*57:01 imaju povećani rizik od porasta vrijednosti ALT-a povezanog s pazopanibom.
English: Serum liver tests should be performed before initiation of treatment with pazopanib, at weeks 3, 5, 7 and 9, then at months 3 and 4, with additional tests as clinically indicated.
Croatian: Treba provjeriti jetrene enzime u serumu prije uvođenja liječenja pazopanibom, u 3., 5., 7. i 9. tjednu, zatim u 3. i 4. mjesecu, s dodatnim testovima ako je klinički indicirano.
English: The preclinical safety profile of pazopanib was assessed in mice, rats, rabbits and monkeys.
Croatian: Neklinički profil sigurnosti primjene pazopaniba procjenjivan je u miševa, štakora, zečeva i majmuna.
English: If the concomitant administration of an H2-receptor antagonist is medically necessary, pazopanib should be taken without food at least 2 hours before or at least 10 hours after a dose of an H2-receptor antagonist.
Croatian: Ukoliko je istodobna primjena antagonista H2 receptora medicinski neophodna, pazopanib treba uzeti bez hrane najmanje 2 sata prije ili najmanje 10 sati nakon doze antagonista H2 receptora.
English: In the cytokine pre-treated subgroup, the majority (75%) had received interferon-based treatment.
Croatian: U skupini ranije liječenih citokinima, većina (75%) je primala terapiju temeljenu na interferonu.
English: Prior anthracycline therapy may be a risk factor for cardiac dysfunction.
Croatian: Prethodno liječenje antraciklinima može biti čimbenik rizika za disfunkciju srca.
English: Please consult your doctor or nurse for advice.
Croatian: Savjetujte se sa svojim liječnikom ili medicinskom sestrom.
English: Effect of concomitant use of pazopanib and simvastatin
Croatian: Učinak istodobne uporabe pazopaniba i simvastatina
English: Ninety-eight percent (98%) of subjects received prior doxorubicin, 70% prior ifosfamide, and 65% of subjects had received at least three or more chemotherapeutic agents prior to study enrolment.
Croatian: Devedeset i osam posto (98%) bolesnika prethodno je primilo doksorubicin, 70% ifosfamid, a njih 65% primilo je najmanje tri ili više kemoterapijskih lijekova prije uključenja u ispitivanje.
English: Frequency (all grades)
Croatian: Učestalost (svi stupnjevi)
English: Tell your doctor if you notice significant weight gain or tiredness.
Croatian: Recite svom liječniku ako primijetite značajno povećanje tjelesne težine ili umor.
English: Pazopanib should not be used in children younger than 2 years of age because of safety concerns with regard to organ growth and maturation (see sections 4.4 and 5.3).
Croatian: Pazopanib se ne smije primjenjivati u djece mlađe od 2 godine zbog sigurnosnih razloga vezanih uz rast i sazrijevanje organa (vidjeti dijelove 4.4 i 5.3).
English: From the total of 435 patients in this study, 233 patients were treatment-naïve and 202 were second-line patients who had received one prior IL-2 or INF-based therapy.
Croatian: Od ukupno 435 bolesnika u ovom ispitivanju, 233 bolesnika nije ranije primalo terapiju, a 202 bolesnika druge linije je ranije primilo jednu IL-2 ili INF-baziranu terapiju.
English: Risk factors
Croatian: Čimbenici rizika
English: If you forget to take Votrient Do not take a double dose to make up for a forgotten dose.
Croatian: Nemojte uzeti dvostruku dozu kako bi nadoknadili zaboravljenu dozu.
English: OS = overall survival * Overall survival for the respective STS histological subgroups (leiomyosarcoma, synovial sarcoma and “Other” STS) should be interpreted with caution due to the small number of subjects and wide confidence intervals
Croatian: OS = sveukupno preživljenje Sveukupno preživljenje za navedene STS histološke podgrupe (leiomiosarkom, sinovijalni sarkom i „ostali“ sarkomi) treba interpretirati s oprezom zbog malog broja ispitanika i širokih intervala pouzdanosti
English: Table 2 Treatment-related adverse reactions reported in RCC studies (n = 1149) or during post-marketing period
Croatian: Tablica 2 Nuspojave povezane s liječenjem prijavljene u ispitivanjima RCC-a (n=1149) ili nakon stavljanja lijeka u promet
English: System Organ Class
Croatian: Razred organskog sustava
English: Thirteen of the 15 subjects in the pazopanib arm of the STS Phase III study had concurrent hypertension which may have exacerbated cardiac dysfunction in patients at risk by increasing cardiac after-load.
Croatian: Trinaest od 15 ispitanika u kraku s pazopanibom u ispitivanju STS-a faze III imalo je istodobno hipertenziju koja je možda pogoršala disfunkciju srca u rizičnih bolesnika, povećanjem naknadnog opterećenja srca.
English: Other key eligibility criteria of the VEG110727 study were: histological evidence of high or intermediate grade malignant STS and disease progression within 6 months of therapy for metastatic disease, or recurrence within 12 months of (neo) -/adjuvant therapy.
Croatian: Ostali ključni kriteriji VEG110727 ispitivanja bili su: histološki dokaz malignog STS-a visokog ili srednjeg stupnja i progresija bolesti unutar 6 mjeseci od liječenja metastatske bolesti, ili povratak bolesti unutar 12 mjeseci od (neo)adjuvantnog liječenja.
English: Votrient can make some conditions worse or cause serious side effects.
Croatian: Votrient može pogoršati neka stanja ili izazvati ozbiljne nuspojave.
English: Don't take Votrient with food, as it affects the way the medicine is absorbed.
Croatian: Ne uzimajte Votrient s hranom jer utječe na način apsorpcije lijeka.
English: How to take Votrient
Croatian: Kako uzimati Votrient
English: Votrient has no or negligible influence on the ability to drive and use machines.
Croatian: Votrient ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Infections (with or without neutropenia)†
Croatian: Infekcije i infestacije često infekcije (s ili bez neutropenije)†
English: Four of the 15 subjects had full recovery (within 5% of baseline) and 5 had partial recovery (within the normal range, but >5% below baseline).
Croatian: Potpuni oporavak imala su četiri od 15 ispitanika (unutar 5% odstupanja od početnih vrijednosti), a 5 ispitanika imalo je djelomični oporavak (unutar normalnog raspona, ali >5% ispod početne vrijednosti).
English: You must look out for certain symptoms while you are taking Votrient to reduce the risk of any problems.
Croatian: Za vrijeme uzimanja lijeka Votrient morate pripaziti na određene simptome kako bi smanjili rizik bilo kakvog problema.
English: Effect of food on pazopanib
Croatian: Učinci hrane na pazopanib
English: The majority of these cases describe mucositis f Frequency is based on laboratory value tables from VEG110727 (N=240).
Croatian: Većina slučajeva opisuje mukozitis f Frekvencija se temelji na tablicama laboratorijskih vrijednosti iz ispitivanja VEG110727 (n=240).
English: Pazopanib may have a greater impact on SN-38 disposition in subjects with the UGT1A1*28 polymorphism relative to subjects with the wild-type allele.
Croatian: Pazopanib možda ima veći utjecaj na SN-38 dispoziciju u ispitanika s UGT1A1*28 polimorfizmom u odnosu na ispitanike s divljim tipom alela.
English: This can result in weight increase and tiredness.
Croatian: To može rezultirati povećanjem tjelesne težine i umorom.
English: Neutropenia, thrombocytopenia and palmar-plantar erythrodysaethesia syndrome were observed more frequently in patients of East Asian descent.
Croatian: Neutropenija, trombocitopenija i sindrom palmarno-plantarne eritrodizestezije češće su primijećeni u bolesnika podrijetlom iz istočne Azije.
English: Before initiating pazopanib, this risk should be carefully considered in patients with risk factors such as hypertension or history of aneurysm.
Croatian: Prije početka primjene pazopaniba potrebno je pažljivo razmotriti ovaj rizik u bolesnika s čimbenicima rizika kao što su hipertenzija ili aneurizma u anamnezi.
English: Response rate (CR+PR) % (95% CI) Duration of response Median (weeks) (95% CI) 38.9 (16.7, 40.0)
Croatian: Stopa odgovora (CR+PR) % (95% CI) Trajanje odgovora Medijan (tjedni) (95% CI) 38,9 (16,7; 40,0)
English: Votrient is used in adults to treat: - kidney cancer that is advanced or has spread to other organs.
Croatian: Votrient se u odraslih koristi za liječenje: - karcinoma bubrega koji je uznapredovao ili se proširio na druge organe.
English: Medicinal products that raise gastric pH
Croatian: Lijekovi koji povisuju želučani pH
English: Based on in vitro IC50 and in vivo plasma Cmax values, pazopanib metabolites GSK1268992 and GSK1268997 may contribute to the net inhibitory effect of pazopanib towards BCRP.
Croatian: Temeljem vrijednosti in vitro IC50 i Cmax in vivo u plazmi, metaboliti pazopaniba GSK1268992 i GSK1268997 mogu doprinijeti ukupnom inhibitornom učinku pazopaniba na BCRP.
English: See section 4.4 for liver monitoring and dose modification for patients with drug-induced hepatotoxicity.
Croatian: Vidjeti dio 4.4 za praćenje funkcije jetre i prilagodbu doze u bolesnika s hepatotoksičnošću uzrokovanom primjenom lijeka.
English: Patients should avoid driving or using machines if they feel dizzy, tired or weak.
Croatian: Bolesnici trebaju izbjegavati upravljanje vozilima i rad sa strojevima ako osjećaju omaglicu, umor ili slabost.
English: One of these metabolites inhibits the proliferation of VEGF-stimulated human umbilical vein endothelial cells with a similar potency to that of pazopanib, the others are 10- to 20-fold less active.
Croatian: Jedan od tih metabolita inhibira proliferaciju endotelnih stanica umbilikalne vene stimuliranih VEGF-om potentnošću sličnom pazopanibu, dok su ostali 10 do 20 puta manje aktivni.
English: Because the mechanism of action of pazopanib can severely affect organ growth and maturation during early post-natal development in rodents (see section 5.3), pazopanib should not be given to paediatric patients younger than 2 years of age.
Croatian: Kako mehanizam djelovanja pazopaniba može ozbiljno utjecati na razvoj i sazrijevanje organa tijekom ranog postanatalnog razvoja u glodavaca (vidjeti dio 5.3), pazopanib se ne smije davati pedijatrijskim bolesnicima mlađim od 2 godine života.
English: Votrient is not recommended if you are pregnant.
Croatian: Votrient se ne preporučuje u trudnoći.
English: Baseline and periodic evaluation of LVEF is recommended in patients at risk of cardiac dysfunction.
Croatian: Početna i povremene procjene LVEF-a se preporučuju u bolesnika s rizikom disfunkcije srca.
English: OS Overall ITT
Croatian: OS Sveukupna ITT
English: Pharmacotherapeutic group: Antineoplastic agents, other antineoplastic agents, protein kinase inhibitors, ATC code: L01XE11
Croatian: Farmakoterapijska skupina: Antineoplastični lijekovi, inhibitori protein kinaze, ATK oznaka: L01XE11
English: Renal cell carcinoma (RCC)
Croatian: Karcinom bubrega (RCC)