FrancophonIA/ELRC3.0 huggingface dataset:
English: 1 ml solution contains 40 international units insulin human* (equivalent to 1.4 mg).
Danish: 1 ml injektionsvæske indeholder 40 internationale enheder humant insulin* (svarende til 1,4 mg).
English: Actrapid vial (40 international units/ml)/Actrapid vial (100 international units/ml) During use or when carried as a spare: Store below 25°C.
Danish: Actrapid hætteglas (40 internationale enheder/ml)/Actrapid hætteglas (100 internationale enheder/ml) Under brug eller medbragt som reserve: Opbevar under 25°C.
English: - If the second and third characters are H7 or T6, the manufacturer is Novo Nordisk Production SAS, 45 Avenue d'Orléans, F-28000 Chartres, France.
Danish: - Hvis andet og tredje skrifttegn er H7 eller T6, så er fremstilleren Novo Nordisk Production SAS, 45 Avenue d'Orléans, F-28000 Chartres, Frankrig.
English: Dose selector
Danish: Trykknap Dosisvælger
English: Cartridge (type 1 glass) with a plunger (bromobutyl) and a rubber closure (bromobutyl/polyisoprene) containing 3 ml of solution in a pre-filled multidose disposable pen made of polypropylene.
Danish: Cylinderampul (type 1-glas) med et stempel (brombutyl) og en gummiprop (brombutyl/polyisopren) i en fyldt engangspen til flergangsbrug lavet af polypropylen, indeholdende 3 ml injektionsvæske.
English: Actrapid is often given in combination with intermediate-acting or long-acting insulin preparations.
Danish: Actrapid gives ofte i kombination med insulin med middellang virkningstid eller langtidsvirkende insulin.
English: You can carry it with you and keep it at room temperature (below 25ºC) for up to 4 weeks.
Danish: Du kan have det med dig og opbevare det ved stuetemperatur (under 25°C) i op til 4 uger.
English: Draw into the syringe the same amount of air as the dose of Actrapid.
Danish: Træk en mængde luft ind i sprøjten, som svarer til dosen af Actrapid.
English: Read carefully the Instructions on how to use Actrapid InnoLet included in this package leaflet.
Danish: Vær omhyggelig med at læse brugervejledningen til Actrapid InnoLet i denne indlægsseddel.
English: 1 ml solution contains 100 international units insulin human* (equivalent to 3.5 mg).
Danish: 1 ml injektionsvæske indeholder 100 internationale enheder humant insulin* (svarende til 3,5 mg).
English: The following substances may increase the patient's insulin requirement: Oral contraceptives, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone and danazol.
Danish: Orale kontraceptiva, thiazider, glukokortikoider, thyreoideahormoner,sympatomimetika, væksthormon og danazol.
English: ► Keep the needle under your skin for at least 6 seconds to make sure that you have injected all the insulin.
Danish: ► Efter injektionen skal nålen forblive under huden i mindst 6 sekunder for at sikre, at du har injiceret hele insulindosen.
English: You can carry it with you and keep it at room temperature (below 25ºC) for up to 6 weeks.
Danish: Du kan have det med dig og opbevare det ved stuetemperatur (under 25°C) i op til 6 uger.
English: Solution for injection 1 x 3 ml cartridge 5 x 3 ml cartridges 10 x 3 ml cartridges
Danish: Injektionsvæske, opløsning 1 x 3 ml cylinderampul 5 x 3 ml cylinderampuller 10 x 3 ml cylinderampuller
English: FlexPen is designed to be used with NovoFine or NovoTwist disposable needles up to a length of 8 mm. As a precautionary measure, always carry a spare insulin delivery device in case your FlexPen is lost or damaged.
Danish: FlexPen er beregnet til anvendelse sammen NovoFine eller NovoTwist engangsnåle med en længde på op til 8 mm. Medbring for en sikkerheds skyld altid et ekstra insulindispenseringssystem i tilfælde af, at din FlexPen mistes eller ødelægges.
English: • Always use a new needle for each injection.
Danish: • Brug altid en nål til hver injektion.
English: Read carefully the Instructions on how to use Actrapid FlexPen included in this package leaflet.
Danish: Vær omhyggelig med at læse brugervejledningen til Actrapid FlexPen i denne indlægsseddel.
English: The solution is clear, colourless and aqueous.
Danish: Opløsningen er klar, farveløs og vandig.
English: Push the needle into the vial of intermediate- or long-acting insulin, turn the vial and syringe upside down and draw out the dose you have been prescribed.
Danish: Stik nålen ind i hætteglasset med insulinet med middellang eller lang virkningstid, vend hætteglasset og sprøjten med bunden i vejret, og træk den ordinerede dosis ind i sprøjten.
English: Actrapid Penfill is only suitable for subcutaneous injections from a reusable pen.
Danish: Actrapid Penfill er kun egnet til subkutan injektion fra en genanvendelig pen.
English: How to handle Actrapid FlexPen
Danish: Sådan skal du bruge Actrapid FlexPen
English: At the beginning of the insulin treatment, refraction anomalies, oedema and injection site reactions (pain, redness, hives, inflammation, bruising, swelling and itching at the injection site) may occur.
Danish: I starten af insulinbehandlingen kan der forekomme refraktionsanomalier, ødemer og reaktioner på injektionsstedet (smerte, rødme, udslæt, inflammation, blå mærker, hævelser og kløe).
English: ► Needles and Actrapid InnoLet must not be shared.
Danish: ► Nåle og Actrapid InnoLet må ikke deles med andre.
English: Pack sizes of 1 or 5 vials of 10 ml or a multipack of 5 packs of 1 x 10 ml vial.
Danish: Pakningsstørrelser med 1 eller 5 hætteglas a 10 ml eller en multipakning med 5 pakker a 1 x 10 ml hætteglas.
English: How to take Actrapid
Danish: Sådan skal du tage Actrapid
English: Solution for injection 1 vial of 10 ml.
Danish: Injektionsvæske, opløsning 1 hætteglas med 10 ml.
English: Actrapid vial (40 international units/ml)
Danish: Actrapid hætteglas (40 internationale enheder/ml)
English: EU/1/02/230/016 5 packs of 1 x 10 ml vial
Danish: EU/1/02/230/016 5 pakker med 1 x 10 ml hætteglas
English: This may lead to inaccurate dosing that can make your blood sugar level too high or too low.
Danish: Dette kan føre til upræcis dosering, som kan gøre dit blodsukker for højt eller for lavt.
English: Always mix Actrapid and intermediate- or long-acting insulin in the same sequence.
Danish: Bland altid Actrapid og insulinet med middellang eller lang virkningstid i samme rækkefølge.
English: Solution for injection Multipack: 5 packs of 1 x 10 ml vial
Danish: Injektionsvæske, opløsning Multipakning: 5 pakker med 1 x10 ml hætteglas
English: Actrapid vial (40 international units/ml)/Actrapid vial (100 international units/ml) Intravenous use
Danish: Actrapid hætteglas (40 internationale enheder/ml)/Actrapid hættglas (100 internationale enheder) Intravenøs anvendelse
English: Actrapid vial (100 international units/ml)
Danish: Actrapid hætteglas (100 internationale enheder/ml)
English: Actrapid InnoLet is a pre-filled disposable pen containing human insulin.
Danish: Actrapid InnoLet er en fyldt engangspen til flergangsbrug, der indeholder humant insulin.
English: 1 pre-filled pen contains 3 ml equivalent to 300 international units.
Danish: 1 fyldt pen indeholder 3 ml, svarende til 300 internationale enheder.
English: Draw into the syringe the same amount of air as the dose of intermediate- or long-acting insulin.
Danish: Træk en mængde luft ind i sprøjten, som svarer til dosen af insulinet med middellang eller lang virkningstid.
English: EU/1/02/230/017 5 packs of 1 x 10 ml vial
Danish: EU/1/02/230/017 5 pakker med 1 x 10 ml hætteglas
English: Actrapid vial, Penfill and FlexPen:
Danish: Actrapid hætteglas, Penfill og FlexPen:
English: • Screw the needle straight and tightly onto your InnoLet (picture 1A).
Danish: • Skru nålen lige og stramt på din InnoLet (figur 1A) • Fjern den store ydre og den indre nålehætte fra nålen.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTES OF ADMINISTRATION
Danish: LÆGEMIDLETS NAVN, STYRKE OG ADMINISTRATIONSVEJE
English: How to inject Actrapid
Danish: Sådan injiceres Actrapid
English: Actrapid vial (40 international units/ml)/Actrapid vial (100 international units/ml) Administration with a syringe
Danish: Actrapid hætteglas (40 internationale enheder/ml)/Actrapid hætteglas (100 internationale enheder/ml) Administration med injektionssprøjte
English: ► Actrapid Penfill is only suitable for injecting under the skin using a reusable pen.
Danish: ► Actrapid Penfill er kun egnet til indsprøjtning under huden ved hjælp af en genanvendelig pen.
English: 1 vial contains 10 ml equivalent to 1,000 international units.
Danish: 1 hætteglas indeholder 10 ml, svarende til 1000 internationale enheder.
English: Actrapid InnoLet is only suitable for subcutaneous injections.
Danish: Actrapid InnoLet er kun egnet til subkutan injektion.
English: Actrapid FlexPen is only suitable for subcutaneous injections.
Danish: Actrapid FlexPen er kun egnet til subkutan injektion.
English: PC: SN:
Danish: SN: NN:
English: Pack sizes of 1, 5 and 10 cartridges of 3 ml.
Danish: Pakningstørrelser med 1, 5 og 10 cylinderampuller a 3 ml.
English: The insulin will work more quickly if you inject into the waist (abdomen).
Danish: Du vil få en hurtigere virkning, hvis insulinet injiceres i maveskindet.
English: ► After each injection, be sure to remove and discard the needle and store Actrapid without the needle attached.
Danish: ► Husk at fjerne og kassere nålen efter hver injektion og opbevar Actrapid uden nålen påsat.
English: Actrapid Penfill is only suitable for injecting under the skin using a reusable pen.
Danish: Actrapid Penfill er kun egnet til indsprøjtning under huden ved hjælp af en genanvendelig pen.
English: Actrapid FlexPen 100 international units/ml solution for injection in pre-filled pen.
Danish: Actrapid FlexPen 100 internationale enheder/ml injektionsvæske, opløsning i fyldt pen.
English: This may cause inaccurate dosing, which can lead to too high or too low blood sugar level.
Danish: Dette kan føre til ukorrekt dosering, som kan føre til et for højt eller for lavt blodsukkerniveau.
English: 1 vial contains 10 ml equivalent to 400 international units.
Danish: 1 hætteglas indeholder 10 ml, svarende til 400 internationale enheder.
English: EU/1/02/230/013 1 pen of 3 ml EU/1/02/230/014 5 pens of 3 ml EU/1/02/230/015 10 pens of 3 ml
Danish: EU/1/02/230/013 1 pen a 3 ml EU/1/02/230/014 5 penne a 3 ml EU/1/02/230/015 10 penne a 3 ml
English: 1 ml solution contains 40 IU insulin human (equivalent to 1.4 mg),
Danish: 1 hætteglas indeholder 10 ml svarende til 400 IE. 1 ml injektionsvæske indeholder 40 IE humant insulin (svarende til 1,4 mg),
English: Actrapid FlexPen is only suitable for injecting under the skin.
Danish: Actrapid FlexPen er kun egnet til indsprøjtning under huden.
English: EU/1/02/230/010 1 pen of 3 ml EU/1/02/230/011 5 pens of 3 ml EU/1/02/230/012 10 pens of 3 ml
Danish: EU/1/02/230/010 1 pen a 3 ml EU/1/02/230/011 5 penne a 3 ml EU/1/02/230/012 10 penne a 3 ml
English: Injection sites should always be rotated within the same region in order to reduce the risk of lipodystrophy.
Danish: For at nedsætte risikoen for lipodystrofi skal injektionsstedet altid varieres inden for samme område.
English: 1 cartridge contains 3 ml equivalent to 300 international units.
Danish: 1 cylinderampul indeholder 3 ml, svarende til 300 internationale enheder.
English: ► Actrapid FlexPen is only suitable for injecting under the skin.
Danish: ► Actrapid FlexPen er kun egnet til indsprøjtning under huden.
English: Keep the cartridge in the outer carton in order to protect from light.
Danish: Opbevar hætteglasset i den ydre karton for at beskytte mod lys
English: ► Actrapid InnoLet is only suitable for injecting under the skin.
Danish: ► Actrapid InnoLet er kun egnet til indsprøjtning under huden.
English: Checking the insulin flow
Danish: Kontrol af insulingennemløb
English: Actrapid InnoLet is only suitable for injecting under the skin.
Danish: Actrapid InnoLet er kun egnet til indsprøjtning under huden.
English: For detailed user instructions, please refer to the package leaflet.
Danish: Se indlægssedlen for detaljeret brugervejledning.
English: C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION
Danish: C ANDRE FORHOLD OG BETINGELSER FOR MARKEDSFØRINGSTILLADELSEN Periodiske, opdaterede sikkerhedsindberetninger (PSUR'er)
English: Each prefilled pen contains 300 IU of human insulin in 3 ml solution for injection.
Danish: Hver fyldt pen indeholder 300 IE humant insulin i 3 ml injektionsvæske, opløsning.
English: EU/1/02/230/005 1 cartridge of 3 ml EU/1/02/230/006 5 cartridges of 3 ml EU/1/02/230/007 10 cartridges of 3 ml
Danish: EU/1/02/230/005 1 cylinderampul a 3 ml EU/1/02/230/006 5 cylinderampuller a 3 ml EU/1/02/230/007 10 cylinderampuller a 3 ml
English: Actrapid InnoLet 100 international units/ml solution for injection in pre-filled pen.
Danish: Actrapid InnoLet 100 internationale enheder/ml injektionsvæske, opløsning i fyldt pen.
English: Actrapid 40 IU/ml Solution for injection Insulin human
Danish: Actrapid 40 IE/ml Injektionsvæske, opløsning Humant insulin
English: Actrapid Penfill 100 international units/ml solution for injection in cartridge.
Danish: Actrapid Penfill 100 internationale enheder/ml injektionsvæske, opløsning i cylinderampul.
English: Then turn the vial and syringe upside down and draw up the prescribed dose of Actrapid.
Danish: Vend derefter hætteglasset og sprøjten med bunden i vejret og træk den ordinerede dosis Actrapid ind i sprøjten.
English: Each cartridge contains 300 IU of human insulin in 3 ml solution for injection.
Danish: Hver cylinderampul indeholder 300 IE humant insulin i 3 ml injektionsvæske, opløsning.
English: Actrapid FlexPen 100 IU/ml Solution for injection in pre-filled pen Insulin human
Danish: Actrapid FlexPen 100 IE/ml Injektionsvæske, opløsning i fyldt pen Humant insulin
English: Each vial contains 1,000 IU of human insulin in 10 ml solution for injection.
Danish: Hvert hætteglas indeholder 1000 IE humant insulin i 10 ml injektionsvæske, opløsning.
English: Actrapid 40 IU/ml Solution for injection Insulin human SC, IV
Danish: Actrapid 40 IE/ml Injektionsvæske, opløsning Humant insulin s.c., i.v.
English: Actrapid 40 international units/ml solution for injection in vial.
Danish: Actrapid 40 internationale enheder/ml injektionsvæske, opløsning i hætteglas.
English: How to handle Actrapid InnoLet
Danish: Sådan skal du bruge Actrapid InnoLet
English: Do not use this medicine after the expiry date, which is stated on the FlexPen label and carton after ‘EXP'.
Danish: Brug ikke dette lægemiddel efter den udløbsdato, der står på FlexPen etiketten og pakningen efter ‘EXP'.
English: Always keep the vial in the outer carton when you are not using it, in order to protect from light.
Danish: Opbevar altid hætteglasset i den ydre karton, når du ikke anvender det, for at beskytte det mod lys.
English: Each vial contains 400 IU of human insulin in 10 ml solution for injection.
Danish: Hvert hætteglas indeholder 400 IE humant insulin i 10 ml injektionsvæske, opløsning.
English: Actrapid 100 IU/ml Solution for injection Insulin human
Danish: Actrapid 100 IE/ml Injektionsvæske, opløsning Humant insulin
English: Actrapid 100 IU/ml Solution for injection Insulin human SC, IV
Danish: Actrapid 100 IE/ml Injektionsvæske, opløsning Humant insulin s.c., i.v.
English: Actrapid Penfill 100 IU/ml Solution for injection in cartridge Insulin human
Danish: Actrapid Penfill 100 IE/ml Injektionsvæske, opløsning i cylinderampul Humant insulin
English: 1 ml solution contains 100 IU insulin human (equivalent to 3.5 mg),
Danish: 1 cylinderampul indeholder 3 ml svarende til 300 IE. 1 ml injektionsvæske indeholder 100 IE humant insulin (svarende til 3,5 mg),
English: Actrapid InnoLet 100 IU/ml Solution for injection in pre-filled pen Insulin human
Danish: Actrapid InnoLet 100 IE/ml Injektionsvæske, opløsning i fyldt pen Humant insulin
English: Do not use this medicine after the expiry date, which is stated on the InnoLet label and carton after ‘EXP'.
Danish: Brug ikke dette lægemiddel efter den udløbsdato, der står på InnoLet etiketten og pakningen efter ‘EXP'.
English: What Actrapid is and what it is used for What you need to know before you use Actrapid How to use Actrapid
Danish: Det skal du vide, før du begynder at tage Actrapid Sådan skal du tage Actrapid Bivirkninger
English: Actrapid FlexPen 100 IU/ml Solution for injection Insulin human SC
Danish: Actrapid FlexPen 100 IE/ml Injektionsvæske, opløsning Humant insulin s.c.
English: EU/1/02/230/001 1 vial of 10 ml EU/1/02/230/002 5 vials of 10 ml
Danish: EU/1/02/230/001 1 hætteglas a 10 ml EU/1/02/230/002 5 hætteglas a 10 ml
English: EU/1/02/230/003 1 vial of 10 ml EU/1/02/230/004 5 vials of 10 ml
Danish: EU/1/02/230/003 1 hætteglas a 10 ml EU/1/02/230/004 5 hætteglas a 10 ml
English: leakage of insulin, blocked needles and inaccurate dosing.
Danish: Dette reducerer risiken for forurening, infektion, udsivning af insulin, blokerede nåle og upræcis dosering.
English: Package leaflet: Information for the user Actrapid 40 IU/ml (international units/ml) solution for injection in vial human insulin
Danish: Indlægsseddel: Information til brugeren Actrapid 40 IE/ml (internationale enheder/ml) injektionsvæske, opløsning i hætteglas humant insulin
English: Needle
Danish: Nål
English: Package leaflet: Information for the user Actrapid FlexPen 100 IU/ml (international units/ml) solution for injection in pre-filled pen human insulin
Danish: Indlægsseddel: Information til brugeren Actrapid FlexPen 100 IE/ml (internationale enheder/ml) injektionsvæske, opløsning i fyldt pen humant insulin
English: Actrapid 100 international units/ml solution for injection in vial.
Danish: Actrapid 100 internationale enheder/ml injektionsvæske, opløsning i hætteglas.
English: Package leaflet: Information for the user Actrapid InnoLet 100 IU/ml (international units/ml) solution for injection in pre-filled pen human insulin
Danish: Indlægsseddel: Information til brugeren Actrapid InnoLet 100 IE/ml (internationale enheder/ml) injektionsvæske, opløsning i fyldt pen humant insulin
English: Actrapid Penfill 100 IU/ml Solution for injection Insulin human SC
Danish: Actrapid Penfill 100 IE/ml Injektionsvæske, opløsning Humant insulin s.c.
English: Package leaflet: Information for the user Actrapid Penfill 100 IU/ml (international units/ml) solution for injection in cartridge human insulin
Danish: Indlægsseddel: Information til brugeren Actrapid Penfill 100 IE/ml (internationale enheder/ml) injektionsvæske, opløsning i cylinderampul humant insulin
English: Package leaflet: Information for the user Actrapid 100 IU/ml (international units/ml) solution for injection in vial human insulin
Danish: Indlægsseddel: Information til brugeren Actrapid 100 IE/ml (internationale enheder/ml) injektionsvæske, opløsning i hætteglas humant insulin
English: Actrapid InnoLet 100 IU/ml Solution for injection Insulin human SC
Danish: Actrapid InnoLet 100 IE/ml Injektionsvæske, opløsning Humant Insulin s.c.
English: Do not use this medicine after the expiry date, which is stated on the vial label and carton after ‘EXP'.
Danish: Brug ikke dette lægemiddel efter den udløbsdato, der står på pakningen og hætteglasset efter ‘EXP'.
English: What Actrapid looks like and contents of the pack
Danish: Udseende og pakningsstørrelser
English: Actrapid is presented as a solution for injection.
Danish: Actrapid er en injektionsvæske, opløsning.
English: • Hold your InnoLet with the needle upwards and tap the cartridge gently with your finger a few times (picture 1B) to make any air bubbles collect at the top of the cartridge.
Danish: • Indstil dosisvælgeren på 2 enheder ved at dreje den med uret • Hold din InnoLet med nålen opad og bank let på cylinderampullen med fingeren et par gange
English: 30 March 2012
Danish: Den 30. marts 2012
English: Outcome of a procedure under Article 107 of Directive 2001/83/EC
Danish: Resultatet af en procedure i henhold til artikel 107 i direktiv 2001/83/EF
English: The European Commission issued a decision on 30 March 2012.
Danish: Europa-Kommissionen traf en afgørelse den 30. marts 2012.
English: What is meprobamate?
Danish: Hvad er meprobamat?
English: These medicines are currently authorised in France, the Netherlands, Finland, Hungary, Italy, Romania and the United Kingdom, as well as Iceland and Norway, under the invented name Equanil and other trade names.
Danish: Sådanne lægemidler er på nuværende tidspunkt godkendt i Frankrig, Nederlandene, Finland, Ungarn, Italien, Rumænien og Det Forenede Kongerige samt i Island og Norge under særnavnet Equanil og andre handelsnavne.
English: Oral meprobamate-containing medicines have been authorised in a number of EU Member States for several decades via national procedures.
Danish: Lægemidler indeholdende meprobamat har i flere tiår været godkendt i en række EU-medlemsstater via nationale procedurer.
English: Why was meprobamate reviewed?
Danish: Hvorfor blev meprobamat vurderet igen?
English: Finally, the CHMP considered that there was limited data on the benefits of meprobamate.
Danish: Endelig tog CHMP i betragtning, at der findes begrænsede data om fordelene ved meprobamat.
English: They are available as tablets containing meprobamate on its own or in combination with other medicines.
Danish: De leveres som tabletter, der indeholder meprobamat enten alene eller kombineret med andre lægemidler.
English: Measures to minimise the risks with meprobamate had already been taken in France.
Danish: I Frankrig var der allerede truffet foranstaltninger til at minimere risiciene i forbindelse med meprobamat.
English: All oral meprobamatecontaining medicines will be withdrawn from the EU market until any further data show that the benefits outweigh the risks.
Danish: Alle orale lægemidler indeholdende meprobamat skal trækkes tilbage fra markedet i EU, indtil til yderligere data viser, at fordelene er større end risiciene.
English: To ensure prescribers have enough time to determine the most appropriate treatments for individual patients, the Committee recommended that the withdrawal of the medicines from the market be carried out gradually, within 15 months of the adoption of the European Commission decision.
Danish: For at give de ordinerende læger tid til at fastlægge den mest velegnede behandling for den enkelte patient anbefalede udvalget, at tilbagetrækningen af lægemidlerne fra markedet sker gradvis i løbet af 15 måneder efter vedtagelsen af Europa-Kommissionens afgørelse.
English: It will be the responsibility of each Member State to set the precise timeframe for this market withdrawal at national level, within the 15 month framework, and to assess the need for other activities, such as recommendations for prescribers and patients on safe and effective alternatives.
Danish: Hver medlemsstat fastsætter på nationalt plan den nøjagtige tidsramme for denne tilbagetrækning inden for 15 måneders fristen og vurderer behovet for andre aktiviteter, såsom anbefalinger til ordinerende læger og patienter om sikre og effektive behandlingsalternativer.
English: The French medicines agency concluded in July 2011 that these measures had not been sufficient to prevent overdose and serious side effects from occurring in France.
Danish: I juli 2011 konkluderede den franske lægemiddelstyrelse, at foranstaltningerne ikke havde været tilstrækkelige til at forhindre forekomsten af overdosering og alvorlige bivirkninger i Frankrig.
English: The French medicines agency was also concerned by reports of these medicines being taken for longer than recommended and cases of overdose (sometimes in combination with other medicines) leading to coma or death.
Danish: Den franske lægemiddelstyrelse var endvidere betænkelig ved indberetninger om, at disse lægemidler anvendes i længere perioder end anbefalet, og at der har været tilfælde af overdosering (undertiden ved anvendelse kombineret med andre lægemidler), som har ført til koma eller død.