FrancophonIA/ELRC3.0 huggingface dataset:
English: • the level of uric acid in blood increased (which can, in severe cases, trigger gout)
Danish: • for meget urinsyre i blodet (hvilket i alvorlige tilfælde kan give podagra)
English: Anticholinergic agents (e.g. atropine, biperiden)
Danish: Antikolinerge midler (f.eks. atropin, biperiden)
English: The combination led to kidney damage (nephropathy with tubular basophilia, rises in plasma urea, plasma creatinine and serum potassium, increases in urine volume and urinary electrolytes from 30 mg/kg/day valsartan + 9 mg/kg/day hydrochlorothiazide in rats and 10 + 3 mg/kg/d in marmosets), probably by way of altered renal haemodynamics.
Danish: stigninger i plasmaurea, plasmakreatinin og serumkalium, stigning i urinvolumen og urinelektrolytter fra 30 mg/kg/dag valsartan + 9 mg/kg/day hydrochlorthiazid hos rotter og 10 + 3 mg/kg/dag hos silkeaber), sandsynligvis som følge af ændringer i renal hæmodynamik.
English: • mild nausea and vomiting
Danish: • let kvalme og opkastning
English: • irregular heart beat
Danish: • uregelmæssigt hjerteslag (puls)
English: Do not take Diovan Comp:
Danish: Tag ikke Diovan Comp
English: If you stop taking Diovan Comp
Danish: Hvis du holder op med at tage Diovan
English: joint pain, muscle pain, swollen lymph nodes and/or flu-like symptoms
Danish: ledsmerter, muskelsmerter, hævede lymfekirtler og /eller influenzalignende symptomer
English: It was concluded that 160-320 mg of valsartan produced clinically relevant reductions in UAE in hypertensive patients with type 2 diabetes.
Danish: (95 % konfidensinterval: 31 til 54 %).Konklusionen var, at 160-320 mg valsartan gav klinisk relevante reduktioner af UAE hos hypertensive patienter med type 2 diabetes.
English: Increase of serum potassium
Danish: Forhøjet serumkalium
English: Other antihypertensive agents
Danish: Andre antihypertensiva
English: Novartis Pharmaceuticals UK Ltd Frimley Business Park Frimley, Camberley Surrey GU16 7SR United Kingdom
Danish: Novartis Pharmaceuticals UK Ltd Frimley Business Park Frimley, Camberley Surrey GU16 7SR Storbritannien
English: The kinetics of valsartan are not markedly affected by the co-administration of hydrochlorothiazide.
Danish: Valsartans kinetik ændres ikke markant af samtidig administration sammen med hydrochlorthiazid.
English: Take special care with Diovan Comp
Danish: Vær ekstra forsigtig med at tage Diovan Comp
English: Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other agents that may increase potassium levels (heparin, etc.) is not recommended.
Danish: Samtidig brug af kaliumtilskud, kaliumbesparende diuretika, salterstatninger indeholdende kalium eller andre præparater, som kan øge kaliumniveauet (heparin o.
English: Interactions related to hydrochlorothiazide
Danish: Interaktioner relateret til hydrochlorthiazid
English: Eye disorders Uncommon
Danish: Øjne Ikke almindelig
English: Diovan Comp fixed-dose combination is indicated in patients whose blood pressure is not adequately controlled on valsartan or hydrochlorothiazide monotherapy.
Danish: Den faste dosiskombination af Diovan Comp er indiceret til behandling af patienter, hvis blodtryk ikke er tilstrækkeligt kontrolleret med valsartan eller hydrochlorthiazid i monoterapi.
English: Nervous system disorders Very rare
Danish: Nervesystemet Meget sjælden
English: • if you suffer from a narrowing of the kidney artery.
Danish: • hvis du lider af forsnævring i blodårerne til nyrerne.
English: What Diovan Comp is and what it is used for Before you take Diovan Comp How to take Diovan Comp Possible side effects
Danish: Det skal du vide, før du begynder at tage Diovan Comp Sådan skal du tage Diovan Comp Bivirkninger
English: • swollen face, tongue or pharynx
Danish: • hævelse i ansigt, tunge eller svælg
English: • [Storage conditions statements-To be completed nationally].
Danish: • [Angivelse af opbevaringsforhold - Udfyldes nationalt]
English: D-90429 Nürnberg provas 80 comp 80/12.5 mg 80 mg / 12.5 mg film-coated tablets oral
Danish: D-90429 Nürnberg provas 80 comp 80/12.5 mg 80 mg / 12,5 mg Filmovertrukne tabletter
English: D-90429 Nürnberg provas 160 maxx 160/25 mg 160 mg / 25 mg film-coated tablets oral
Danish: D-90429 Nürnberg provas 160 maxx 160/25 mg 160 mg / 25 mg Filmovertrukne tabletter
English: • breathing difficulty
Danish: • vejrtrækningsbesvær
English: Medicinal products associated with potassium loss and hypokalaemia (e.g. kaliuretic diuretics, corticosteroids, laxatives, ACTH, amphotericin, carbenoxolone, penicillin G, salicylic acid and derivatives)
Danish: Lægemidler forbundet med kaliumtab og hypokaliæmi (f.eks. kaliuretiske diuretika, kortikosteroider, laksantia, ACTH, amphotericin, carbenoxolon, benzylpenicillin samt salicylsyre og derivater deraf) Hvis disse lægemidler skal ordineres sammen med kombinationen valsartan-hydrochlorthiazid, tilrådes monitorering af plasmakalium.
English: • skin peeling
Danish: • afskallende hud
English: Nervous system disorders Rare
Danish: Nervesystemet Sjælden
English: D-90429 Nürnberg provas 320 maxx 320/25 mg 320 mg / 25 mg film-coated tablets oral
Danish: D-90429 Nürnberg provas 320 maxx 320/25 mg 320 mg / 25 mg Filmovertrukne tabletter
English: • arthritis medicines
Danish: • smertestillende midler
English: • low level of potassium in the blood (sometimes with muscle weakness, muscle spasms,
Danish: • lavt kaliumindhold i blodet (undertiden med muskelsvaghed, muskelkramper, unormal hjerterytme)
English: • high level of potassium in the blood (sometimes with muscle spasms, abnormal heart rhythm)
Danish: • for meget kalium i blodet (undertiden med muskelkramper, unormal hjerterytme)
English: The use of Angiotensin II Receptor Antagonists (AIIRAs) is not recommended during first trimester of pregnancy (see section 4.4).The use of AIIRAs is contra-indicated during the second and third trimester of pregnancy (see sections 4.3 and 4.4).
Danish: Brug af AIIA er kontraindiceret i andet og tredje trimester af graviditeten (se pkt.
English: In severely sodium-depleted and/or volume-depleted patients, such as those receiving high doses of diuretics, symptomatic hypotension may occur in rare cases after initiation of therapy with Diovan Comp.
Danish: Symptomatisk hypotension kan i sjældne tilfælde opstå efter påbegyndt behandling med Diovan Comp hos patienter med alvorlig natrium- og/eller væskemangel, såsom de, der får høje doser af diuretika.
English: • swelling mainly of the face and throat; rash; itching
Danish: • hævelser, især i ansigt og hals, udslæt, kløe
English: Coadministration of thiazide diuretics, including hydrochlorothiazide, may increase the incidence of hypersensitivity reactions to allopurinol.
Danish: Samtidig administration af thiaziddiuretika, herunder hydrochlorthiazid, kan øge forekomsten af overfølsomhedsreaktioner over for allopurinol.
English: • if you have had allergic reactions with the use of other blood pressure-lowering agents of this class (angiotensin II receptor antagonists) or if you have allergy or asthma.
Danish: • hvis du har haft allergiske reaktioner ved brug af andre blodtrykssænkende midler af denne type
English: Due to the hydrochlorothiazide component, Diovan Comp is contraindicated in patients with severe renal impairment (see sections 4.3, 4.4 and 5.2).
Danish: Pga. indholdet af hydrochlorthiazid er Diovan Comp kontraindiceret til patienter med stærkt nedsat nyrefunktion (se pkt.
English: Concomitant use of thiazide diuretics, including hydrochlorothiazide, with beta blockers may increase the risk of hyperglycaemia.
Danish: Samtidig brug af thiaziddiuretika, herunder hydrochlorthiazid, og betablokkere kan øge risikoen for hyperglykæmi.
English: Thiazides, including hydrochlorothiazide, may increase the risk of adverse effects caused by amantadine.
Danish: Amantadin Thiazider, herunder hydrochlorthiazid, kan øge risikoen for bivirkninger forårsaget af amantadin.
English: Diovan Comp is contraindicated in patients with severe hepatic impairment (see sections 4.3, 4.4 and 5.2).
Danish: Diovan Comp er kontraindiceret til patienter med stærkt nedsat leverfunktion (se pkt.
English: You can take Diovan Comp with or without food.
Danish: Brug af Diovan Comp sammen med mad og drikke Du kan tage Diovan Comp med eller uden mad.
English: • other medicines to lower your blood pressure, such as beta blockers or methyldopa, or medicines that tighten your blood vessels or stimulate your heart, such as noradrenaline or adrenaline
Danish: • anden medicin, der sænker blodtrykket, såsom betablokkere eller methyldopa, eller medicin,
English: Amantadine
Danish: Paræstesi
English: • if you are allergic (hypersensitive) to valsartan, hydrochlorothiazide, sulphonamide derivatives
Danish: • hvis du er overfølsom (allergisk) over for valsartan, hydrochlorthiazid, sulfonamidderivater (stoffer, der er kemisk beslægtede med hydrochlorthiazid) eller over for et af de øvrige indholdsstoffer i Diovan Comp.
English: • muscle disorder
Danish: • muskelsmerter
English: Frequency of adverse reactions with valsartan/hydrochlorothiazide
Danish: Bivirkningsfrekvens for valsartan/hydrochlorthiazid
English: Frequency of adverse reactions with valsartan
Danish: Bivirkningfrekvens for valsartan
English: Netherlands Novartis Pharma B.V. Raapopseweg 1
Danish: Holland Novartis Pharma B.V.
English: Sodium and/or volume-depleted patients
Danish: Patienter med natrium- og/eller væskemangel
English: The steady-state volume of distribution of valsartan after intravenous administration is about 17 litres, indicating that valsartan does not distribute into tissues extensively.
Danish: Steady-state fordelingsvolumen af valsartan efter intravenøs administration er cirka 17 liter, hvilket tyder på, at valsartan ikke fordeles i væv i udstrakt grad. Valsartan er i høj grad bundet til serumproteiner (94-97 %), hovedsageligt serumalbumin.
English: • elevation of liver function values
Danish: • forhøjede levertal
English: • itchy rash and other types of rash
Danish: • kløende udslæt og andre typer udslæt
English: Table 3: Frequency of adverse reactions with hydrochlorothiazide Hydrochlorothiazide has been extensively prescribed for many years, frequently in higher doses than those administered with Diovan Comp.
Danish: Hydrochlorthiazid er blevet ordineret ekstensivt i mange år, ofte i højere doser end dem, der administreres med Diovan Comp. Følgende bivirkninger er blevet rapporteret hos patienter, der behandles med thiazid, herunder hydrochlorthiazid, som monoterapi.
English: HOW TO TAKE DIOVAN COMP
Danish: SÅDAN SKAL DU TAGE DIOVAN COMP
English: PHARMACEUTICAL PARTICULARS 6.1 List of excipients
Danish: FARMACEUTISKE OPLYSNINGER 6.1 Hjælpestoffer [Udfyldes nationalt]
English: In a double-blind, randomised, active-controlled trial in patients not adequately controlled on hydrochlorothiazide 12.5 mg, significantly greater mean systolic/diastolic BP reductions were observed with the combination of valsartan/hydrochlorothiazide 160/12.5 mg (12.4/7.5 mmHg) compared to hydrochlorothiazide 25 mg (5.6/2.1 mmHg).
Danish: I et dobbeltblindt, randomiseret, aktiv-kontrolleret forsøg med patienter, der ikke responderede tilstrækkeligt på hydrochlorthiazid 12,5 mg, sås signifikant større middelreduktioner i systolisk/diastolisk blodtryk med kombinationen valsartan/hydrochlorthiazid 160/12,5 mg (12,4/7,5 mmHg) sammenlignet med hydrochlorthiazid 25 mg (5,6/2,1 mmHg).
English: Greece
Danish: Island
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 320/25 mg (85%) and 320/12.5 mg (83%) compared to placebo (45%) and the respective monotherapies, i.e. hydrochlorothiazide 12.5 mg (60%), hydrochlorothiazide 25 mg (66%), and valsartan 320 mg (69%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 320/25 mg (85 %) og 320/12,5 mg (83 %) sammenlignet med placebo (45 %) og de respektive monoterapier, dvs. hydrochlorthiazid 12,5 mg (60 %), hydrochlorthiazid 25 mg (66 %) og valsartan 320 mg (69 %).
English: Diovan Comp and associated names (see Annex I) 80 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 160 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 160 mg/25 mg film-coated tablets Diovan Comp and associated names (see Annex I) 320 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 320 mg/25 mg film-coated tablets [See Annex I - To be completed nationally]
Danish: Diovan Comp og tilhørende navne (se bilag I) 80 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 160 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 160 mg/25 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 320 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 320 mg/25 mg filmovertrukne tabletter [Se Bilag I - Udfyldes nationalt]
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 160/25 mg (81%) and valsartan/ hydrochlorothiazide 160/12.5 mg (76%) compared to placebo (29%) and the respective monotherapies, i.e. hydrochlorothiazide 12.5 mg (41%), hydrochlorothiazide 25 mg (54%), and valsartan 160 mg (59%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 160/25 mg (81 %) og valsartan/hydrochlorthiazid 160/12,5 mg (76 %) sammenlignet med placebo (29 %) og de respektive monoterapier, dvs. hydrochlorthiazid 12,5 mg (41 %), hydrochlorthiazid 25 mg (54 %) og valsartan 160 mg (59 %).
English: If you have accidentally taken too many tablets, contact your doctor, pharmacist or hospital.
Danish: Kontakt lægen, skadestuen eller apoteket, hvis du er kommet til at tage for mange tabletter.
English: In a double-blind, randomised, placebo-controlled, factorial design trial comparing various dose combinations of valsartan/hydrochlorothiazide to their respective components, significantly greater mean systolic/diastolic BP reductions were observed with the combination of valsartan/hydrochlorothiazide 160/12.5 mg (17.8/13.5 mmHg) and 160/25 mg (22.5/15.3 mmHg) compared to placebo (1.9/4.1 mmHg) and the respective monotherapies, i.e., hydrochlorothiazide 12.5 mg (7.3/7.2 mmHg), hydrochlorothiazide 25 mg (12.7/9.3 mmHg) and valsartan 160 mg (12.1/9.4 mmHg).
Danish: I et dobbeltblindt, randomiseret, placebo-kontrolleret faktorforsøg til sammenligning af forskellige dosiskombinationer af valsartan/hydrochlorthiazid i forhold til deres respektive komponenter sås signifikant større middelreduktioner i systolisk/diastolisk blodtryk med kombinationen valsartan/hydrochlorthiazid 160/12,5 mg (17,8/13,5 mmHg) og 160/25 mg (22,5/15,3 mmHg) sammenlignet med placebo (1,9/4,1 mmHg) og de respektive monoterapier, dvs. hydrochlorthiazid 12,5 mg (7,3/7,2 mmHg), hydrochlorthiazid 25 mg (12,7/9,3 mmHg) og valsartan 160 mg (12,1/9,4 mmHg).
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 320/25 mg (75%) and 320/12.5 mg (69%) compared to valsartan 320 mg (53%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 320/25 mg (75 %) og 320/12,5 mg (69 %) sammenlignet med valsartan 320 mg (53 %).
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 80/12.5 mg (64%) compared to placebo (29%) and hydrochlorothiazide (41%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 80/12,5 mg (64 %) sammenlignet med placebo (29 %) og hydrochlorthiazid (41 %).
English: Iodine contrast media
Danish: Kontraststoffer med iod
English: In a double-blind, randomised, active-controlled trial in patients not adequately controlled on valsartan 160 mg, significantly greater mean systolic/diastolic BP reductions were observed with both the combination of valsartan/hydrochlorothiazide 160/25 mg (14.6/11.9 mmHg) and valsartan/hydrochlorothiazide 160/12.5 mg (12.4/10.4 mmHg) compared to valsartan 160 mg (8.7/8.8 mmHg).
Danish: I et dobbeltblindt, randomiseret, aktiv-kontrolleret forsøg med patienter, der ikke responderede tilstrækkeligt på valsartan 160 mg, sås signifikant større middelreduktioner i systolisk/diastolisk blodtryk med både kombinationen valsartan/hydrochlorthiazid 160/25 mg (14,6/11,9 mmHg) og valsartan/hydrochlorthiazid 160/12,5 mg (12,4/10,4 mmHg) sammenlignet med valsartan 160 mg (8,7/8,8 mmHg).
English: In a double-blind, randomised, active-controlled trial in patients not adequately controlled on valsartan 320 mg, significantly greater mean systolic/diastolic BP reductions were observed with both the combination of valsartan/hydrochlorothiazide 320/25 mg (15.4/10.4 mmHg) and valsartan/hydrochlorothiazide 320/12.5 mg (13.6/9.7 mmHg) compared to valsartan 320 mg (6.1/5.8 mmHg).
Danish: I et dobbeltblindt, randomiseret, aktiv-kontrolleret forsøg med patienter, der ikke responderede tilstrækkeligt på valsartan 320 mg, sås signifikant større middelreduktioner i systolisk/diastolisk blodtryk med både kombinationen valsartan/hydrochlorthiazid 320/25 mg (15,4/10,4 mmHg) og valsartan/hydrochlorthiazid 320/12,5 mg (13,6/9,7 mmHg) sammenlignet med valsartan 320 mg (6,1/5,8 mmHg).
English: Diovan Comp and associated names (see Annex I) 80 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 160 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 160 mg/25 mg film-coated tablets Diovan Comp and associated names (see Annex I) 320 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 320 mg/25 mg film-coated tablets Valsartan/hydrochlorothiazide
Danish: Diovan Comp og tilhørende navne (se bilag I) 80 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 160 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 160 mg/25 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 320 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 320 mg/25 mg filmovertrukne tabletter Valsartan/hydrochlorthiazid
English: • Medicines should not be disposed of via wastewater or household waste.
Danish: Af hensyn til miljøet må du ikke smide medicinrester i afløbet, toilettet eller skraldespanden.
English: Marketing Authorisation Holder and Manufacturer [See Annex I - To be completed nationally]
Danish: Indehaver af markedsføringstilladelsen og fremstiller [Se bilag I - Udfyldes nationalt]
English: Diovan Comp and associated names (see Annex I) 80 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 160 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 160 mg/25 mg film-coated tablets Diovan Comp and associated names (see Annex I) 320 mg/12.5 mg film-coated tablets Diovan Comp and associated names (see Annex I) 320 mg/25 mg film-coated tablets [See Annex I - To be completed nationally] Valsartan/hydrochlorothiazide
Danish: Diovan Comp og tilhørende navne (se bilag I) 80 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 160 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 160 mg/25 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 320 mg/12,5 mg filmovertrukne tabletter Diovan Comp og tilhørende navne (se bilag I) 320 mg/25 mg filmovertrukne tabletter [Se bilag I - Udfyldes nationalt] Valsartan/hydrochlorthiazid
English: In a double-blind, randomised, active-controlled trial in patients not adequately controlled on valsartan 80 mg, significantly greater mean systolic/diastolic BP reductions were observed with the combination of valsartan/hydrochlorothiazide 80/12.5 mg (9.8/8.2 mmHg) compared to valsartan 80 mg (3.9/5.1 mmHg) and valsartan 160 mg (6.5/6.2 mmHg).
Danish: I et dobbeltblindt, randomiseret, aktiv-kontrolleret forsøg med patienter, der ikke responderede tilstrækkeligt på valsartan 80 mg, sås signifikant større middelreduktioner i systolisk/diastolisk blodtryk med kombinationen valsartan/hydrochlorthiazid 80/12,5 mg (9,8/8,2 mmHg) sammenlignet med valsartan 80 mg (3,9/5,1 mmHg) og valsartan 160 mg (6,5/6,2 mmHg).
English: Spain
Danish: Sverige
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 160/25 mg (68%) and 160/12.5 mg (62%) compared to valsartan 160 mg (49%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 160/25 mg (68 %) og 160/12,5 mg (62 %) sammenlignet med valsartan 160 mg (49 %).
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 80/12.5 mg (51%) compared to valsartan 80 mg (36%) and valsartan 160 mg (37%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 80/12,5 mg (51 %) sammenlignet med valsartan 80 mg (36 %) og valsartan 160 mg (37 %).
English: Cordinate plus 80/12.5 mg 80 mg / 12.5 mg film-coated tablets oral
Danish: Cordinate plus 80/12.5 mg 80 mg / 12,5 mg Filmovertrukne tabletter
English: In a double-blind, randomised, placebo-controlled, factorial design trial comparing various dose combinations of valsartan/hydrochlorothiazide to their respective components, significantly greater mean systolic/diastolic BP reductions were observed with the combination of valsartan/hydrochlorothiazide 320/12.5 mg (21.7/15.0 mmHg) and 320/25 mg (24.7/16.6 mmHg) compared to placebo (7.0/5.9 mmHg) and the respective monotherapies, i.e. hydrochlorothiazide 12.5 mg (11.1/9.0 mmHg), hydrochlorothiazide 25 mg (14.5/10.8 mmHg) and valsartan 320 mg (13.7/11.3 mmHg).
Danish: I et dobbeltblindt, randomiseret, placebo-kontrolleret faktorforsøg til sammenligning af forskellige dosiskombinationer af valsartan/hydrochlorthiazid i forhold til deres respektive komponenter sås signifikant større middelreduktioner i systolisk/diastolisk blodtryk med kombinationen valsartan/hydrochlorthiazid 320/12,5 mg (21,7/15,0 mmHg) og 320/25 mg (24,7/16,6 mmHg) sammenlignet med placebo (7,0/5,9 mmHg) og de respektive monoterapier, dvs. hydrochlorthiazid 12,5 mg (11,1/9,0 mmHg), hydrochlorthiazid 25 mg (14,5/10,8 mmHg) og valsartan 320 mg (13,7/11,3 mmHg).
English: Co-Dalzad (160+25) mg 160 mg / 25 mg film-coated tablets oral
Danish: Co-Dalzad (160+25) mg 160 mg / 25 mg Filmovertrukne tabletter
English: In addition, a significantly greater percentage of patients responded (diastolic BP <90 mmHg or reduction ≥10 mmHg) with valsartan/hydrochlorothiazide 80/12.5 mg (60%) compared to hydrochlorothiazide 12.5 mg (25%) and hydrochlorothiazide 25 mg (27%).
Danish: Desuden responderede en signifikant højere procentdel af patienterne (diastolisk blodtryk <90 mmHg eller reduktion ≥10 mmHg) med valsartan/hydrochlorthiazid 80/12,5 mg (60 %) sammenlignet med hydrochlorthiazid 12,5 mg (25 %) og hydrochlorthiazid 25 mg (27 %).