FrancophonIA/ELRC3.0 huggingface dataset:
English: For abacavir there was a decrease in Cmax with 23% and AUC was unchanged.
Slovenian: Pri abakavirju se je vrednost Cmax zmanjšala za 23%, AUC pa je ostala nespremenjena.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Slovenian: Opisani so bili primeri osteonekroze, zlasti pri bolnikih s splošno znanimi dejavniki tveganja, napredovalno boleznijo HIV ali dolgotrajno izpostavljenostjo CART.
English: Clinical diagnosis of suspected hypersensitivity to ABC remains the basis for clinical decision making.
Slovenian: Klinična diagnoza suma na preobčutljivostno reakcijo za ABC je še vedno osnova kliničnega odločanja.
English: The effect of a high fat meal on the Triumeq tablet was evaluated in a subgroup of subjects in this study (n=12).
Slovenian: Učinek zelo mastnega obroka na tableto zdravila Triumeq so ocenjevali pri podskupini oseb v tej študiji (n = 12).
English: Triumeq can also affect how some other medicines work.
Slovenian: Zdravilo Triumeq lahko vpliva tudi na delovanje drugih zdravil.
English: The systemic exposures were equivalent to 7 to 21 times the expected systemic exposure in humans.
Slovenian: Sistemske izpostavljenosti so bile ekvivalentne od 7- do 24-kratni sistemski izpostavljenosti, kakršna se pričakuje pri človeku.
English: Look out for important symptoms Some people taking medicines for HIV infection develop other conditions, which can be serious.
Slovenian: Bodite pozorni na pomembne simptome Pri nekaterih ljudeh, ki jemljejo zdravila za zdravljenje okužbe z virusom HIV, se pojavijo druge zdravstvene težave, ki so lahko resne.
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Slovenian: Bolnikom je treba svetovati, naj poiščejo zdravniško pomoč, če se jim pojavijo bolečine v sklepih, okorelost sklepov ali težave pri gibanju.
English: Both of these active ingredients can cause a serious allergic reaction known as a hypersensitivity reaction.
Slovenian: Obe navedeni zdravilni učinkovini lahko povzročita hudo alergijsko reakcijo, tako imenovano preobčutljivostno reakcijo.
English: Increases in serum creatinine occurred within the first week of treatment with dolutegravir and remained stable through 96 weeks.
Slovenian: Zvišane vrednosti serumskega kreatinina so se pojavile v prvem tednu zdravljenja z dolutegravirjem in ostale nespremenjene skozi 96 tednov.
English: Emtricitabine, didanosine, stavudine, zidovudine.
Slovenian: emtricitabin, didanozin, stavudin in zidovudin
English: Triumeq should not be administered to adults or adolescents who weigh less than 40 kg because it is a fixed-dose tablet that cannot be dose reduced.
Slovenian: Zdravilo Triumeq se ne sme dajati odraslim ali mladostnikom, ki tehtajo manj kot 40 kg, saj gre za tableto s fiksnim odmerkom, ki se ga ne da zmanjševati.
English: The concentration of active substance necessary to effect viral replication by 50% (IC50 - half maximal inhibitory concentration) varied according to virus and host cell type.
Slovenian: Koncentracija učinkovine, potrebna za 50% učinek na replikacijo virusov (IC50 polovična maksimalna inhibitorna koncentracija), se je razlikovala glede na virus in tip gostiteljske celice.
English: Data from clinical trials showed limited numbers of myocardial infarction and could not exclude a small increase in risk.
Slovenian: Podatki iz kliničnih študij so pokazali omejeno število miokardnih infarktov, kar ne more izključiti majhnega povečanja tveganja.
English: It is recommended women who are HIV-positive do not breast-feed because HIV infection can be passed on to the baby in breast milk.
Slovenian: Za ženske, ki so HIV-pozitivne, dojenje ni priporočljivo, saj se okužba z virusom HIV lahko z materinim mlekom prenese na otroka.
English: Dolutegravir has a <10-fold change against 94% of the 705 clinical isolates.
Slovenian: Dolutegravir ima <10-kratne spremembe občutljivosti proti 94% od 705 kliničnih izolatov.
English: Do not take Triumeq:
Slovenian: Ne jemljite zdravila Triumeq:
English: • emtricitabine, etravirine, efavirenz, nevirapine or tipranavir/ritonavir, to treat HIV infection
Slovenian: • emtricitabin, etravirin, efavirenz, nevirapin ali tipranavir/ritonavir za zdravljenje okužb z virusom HIV
English: Do not discontinue Triumeq without consulting your doctor, as this may harm you and your unborn child.
Slovenian: Brez posvetovanja z zdravnikom ne prenehajte jemati zdravilo Triumeq, ker to lahko škoduje vam in vašemu nerojenemu otroku.
English: Lamivudine monotherapy is generally not considered an adequate treatment for hepatitis B, since the risk for hepatitis B resistance development is high.
Slovenian: Monoterapija z lamivudinom na splošno ne velja za ustrezno zdravljenje hepatitisa B, ker je tveganje za razvoj odpornosti hepatitisa B visoko.
English: Both the time to viral suppression and change from baseline analyses were pre-specified and adjusted for multiplicity.
Slovenian: Tako čas do virusne supresije kot tudi sprememba odklona od izhodiščne vrednosti analize sta bila vnaprej določena in prilagojena za mnogoterost.
English: → Talk to your doctor immediately.
Slovenian: → se takoj posvetujte z zdravnikom.
English: Abacavir and lamivudine are potent selective inhibitors of HIV-1 and HIV-2.
Slovenian: Abakavir in lamivudin sta močna selektivna zaviralca HIV-1 in HIV-2.
English: • other medicines containing lamivudine, used to treat HIV infection or hepatitis B infection
Slovenian: • druga zdravila, ki vsebujejo lamivudin in se uporabljajo za zdravljenje okužb z virusom HIV ali hepatitisom B.
English: • rifampicin, to treat tuberculosis (TB) and other bacterial infections
Slovenian: • rifampicin za zdravljenje tuberkuloze (TBC) in drugih bakterijskih okužb
English: These mutations have been selected in patients with pre-existing raltegravir resistance and who were then treated with dolutegravir (listed as secondary mutations for dolutegravir).
Slovenian: Te mutacije so bile izbrane pri bolnikih s predhodno odpornostjo na raltegravir in zdravljenih z dolutegravirjem (navedene kot sekundarne mutacije za dolutegravir).
English: Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na učinkovine ali na katero koli pomožno snov, navedeno v poglavju 6.1.
English: In the SINGLE study a mean change from baseline of 12.6 µmol/L was observed after 96 weeks of treatment.
Slovenian: V študiji SINGLE je bil povprečni odklon od izhodiščne vrednosti 12,6 mol/L zabeležen po 96 tednih zdravljenja.
English: erythema multiform1, Stevens-Johnson syndrome1, toxic epidermal necrolysis1
Slovenian: multiformni eritem 1, Stevens-Johnsonov sindrom 1, toksična epidermalna nekroliza
English: You are more likely to develop this reaction if you have a gene called HLA-B*5701 (but you can get a reaction even if you don't have this gene).
Slovenian: Pojav te reakcije je verjetnejši, če imate gen HLA-B*5701 (vendar se vam reakcija lahko pojavi, tudi če nimate tega gena).
English: Primary mutations for raltegravir/elvitegravir (Q148H/R/K, N155H, Y143R/H/C, E92Q, T66I) do not affect the in vitro susceptibility of dolutegravir as single mutations.
Slovenian: Primarne mutacije za raltegravir/elvitegravir (Q148H/R/K, N155H, Y143R/H/C, E92Q, T66I) ne vplivajo na občutljivost dolutegravirja in vitro kot posamezne mutacije.
English: → If you think this applies to you, tell your doctor.
Slovenian: → Če menite, da to velja za vas, se posvetujte z zdravnikom.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Slovenian: V študijah na živalih lamivudin ni pokazal teratogenih učinkov, obstajajo pa indikacije za povečano embrionalno smrtnost kuncev, in to že pri relativno nizkih sistemskih izpostavljenostih, ki so primerljive s tistimi doseženimi pri ljudeh.
English: Taking Triumeq at the time of becoming pregnant or during the first twelve weeks of pregnancy, may increase the risk of a type of birth defect, called neural tube defect, such as spina bifida (malformed spinal cord).
Slovenian: Jemanje zdravila Triumeq ob zanositvi ali v prvih dvanajstih tednih nosečnosti lahko poveča tveganje za prirojeno napako, imenovano okvara nevralne cevi, kot je spina bifida (nepravilno oblikovana hrbtenjača).
English: In these cases the physician should refer to the individual product information for these medicinal products.
Slovenian: V takšnih primerih mora zdravnik upoštevati navodila za uporabo posameznih zdravil.
English: Restarting abacavir in such patients must be done in a setting where medical assistance is readily available.
Slovenian: Pri takih bolnikih je treba ponovno uvedbo abakavirja izvesti v pogojih, kjer je zdravniška pomoč takoj na voljo.
English: Patients should be advised that Triumeq or any other antiretroviral therapy does not cure HIV infection and that they may still develop opportunistic infections and other complications of HIV infection.
Slovenian: Bolnike je treba opozoriti, da Triumeq ali katera koli druga protiretrovirusna terapija ne ozdravi okužbe s HIV in da se lahko pri njih vseeno pojavijo oportunistične okužbe in drugi s HIV povezani zapleti.
English: After starting treatment, the immune system becomes stronger, and may attack the infections, which can cause symptoms of infection or inflammation.
Slovenian: Ko se začne zdravljenje HIV, se imunski sistem okrepi in začne napadati povzročitelje okužbe, kar lahko privede do simptomov okužbe ali vnetja.
English: • supplements or multivitamins containing calcium, iron or magnesium.
Slovenian: • dodatke ali multivitaminske pripravke, ki vsebujejo kalcij, železo ali magnezij.
English: If your doctor advises that you can start taking Triumeq again, you may be asked to take your first doses in a place where you will have ready access to medical care if you need it.
Slovenian: Če vam zdravnik svetuje, da lahko ponovno začnete z jemanjem zdravila Triumeq, vam bo morda naročil, da prvi odmerek vzamete na mestu, kjer bo takoj na voljo zdravniška pomoč, če bi jo potrebovali.
English: People with advanced HIV infection or AIDS have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Slovenian: Osebe z napredovalo okužbo z virusom HIV ali AIDS imajo oslabljen imunski sistem in večjo verjetnost, da razvijejo hujše okužbe (oportunistične okužbe).
English: What Triumeq is and what it is used for 2.
Slovenian: Kaj je zdravilo Triumeq in za kaj ga uporabljamo 2.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jirovecii pneumonia (often referred to as PCP).
Slovenian: Pomembni primeri so citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami ter s Pneumocystis jiroveci povzročena pljučnica (pogosto omenjena kot PCP).
English: These findings should be considered for any child exposed in utero to nucleoside and nucleotide analogues, who presents with severe clinical findings of unknown aetiology, particularly neurologic findings.
Slovenian: Te ugotovitve je treba upoštevati pri vseh otrokih, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom, pri katerih se pojavijo resne klinične ugotovitve neznanega vzroka, še zlasti nevrološke.
English: Due to the potential risk of neural tube defects with dolutegravir, Triumeq should not be used during the first trimester unless there is no alternative.
Slovenian: Zaradi morebitnega tveganja za nastanek okvar nevralne cevi se zdravila Triumeq ne sme uporabljati v prvem trimesečju, razen če ni alternative.
English: Very rarely cases of erythema multiforme, Stevens-Johnson syndrome or toxic epidermal necrolysis have been reported where abacavir hypersensitivity could not be ruled out.
Slovenian: Zelo redko so poročali o primerih multiformnega eritema, Stevens-Johnsonovega sindroma ali toksične epidemalne nekrolize, kjer preobčutljivosti za abakavir ni bilo mogoče izključiti.
English: Changes in laboratory chemistries
Slovenian: Spremembe v izvidih laboratorijskih biokemijskih preiskav
English: If you are hypersensitive to Triumeq, return all your unused Triumeq tablets for safe disposal.
Slovenian: Če ste preobčutljivi na zdravilo Triumeq, vrnite vse neporabljene tablete zdravila Triumeq, da se varno uničijo.
English: Investigations: Common:
Slovenian: Preiskave: Pogosti:
English: At baseline, median patient age was 35 years, 16% were female, 32% non-white, 7% had hepatitis C coinfection and 4% were CDC Class C, these characteristics were similar between treatment groups.
Slovenian: Ob izhodišču je bila mediana starost bolnikov 35 let, 16% je bilo žensk, 32% ne-belcev, 7% jih je imelo sočasno okužbo z virusom hepatitisa C, 4% pa jih je bilo razvrščenih v CDC razred C; te lastnosti so bile pri obeh terapevtskih skupinah podobne.
English: The absolute bioavailability of oral abacavir and lamivudine in adults is about 83% and 80-85% respectively.
Slovenian: Pri odraslih znaša absolutna biološka razpoložljivost abakavirja in lamivudina po peroralnem dajanju približno 83% oziroma 80 - 85%.
English: In further selection experiments using clinical isolates of subtype B, mutation R263K was seen in all five isolates (after 20 weeks and onwards).
Slovenian: Pri nadaljnjih preskušanjih selekcije z uporabo kliničnih izolatov podtipa B so pri vseh petih izolatih opazili mutacijo R263K (po 20 tednih in naprej).
English: • if you are allergic (hypersensitive) to dolutegravir, abacavir (or any other medicine containing abacavir), or lamivudine, or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični (preobčutljivi) na dolutegravir, abakavir (ali katero koli drugo zdravilo, ki vsebuje abakavir) ali lamivudin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: In the case of the Q148-mutation viruses, increasing dolutegravir fold change is seen as the number of secondary mutations increase.
Slovenian: V primeru virusov z mutacijo Q148 se povečevanje spremembe občutljivosti odraža kot število povečanja sekundarnih mutacij.
English: → Talk to your doctor about the risks and benefits of taking Triumeq.
Slovenian: → Posvetujte se z zdravnikom o tveganjih in koristih jemanja zdravila Triumeq.
English: Your doctor may advise you to stop taking Triumeq.
Slovenian: Zdravnik vam bo morda svetoval, da prenehate jemati zdravilo Triumeq.
English: There are no clinical study data on the effects of Triumeq in the paediatric population.
Slovenian: Ni podatkov iz kliničnih študij o učinkih zdravila Triumeq pri pediatrični populaciji.
English: • joint pain, stiffness and bone problems You need to know about important signs and symptoms to look out for while you're taking Triumeq.
Slovenian: • bolečine v sklepih, otrplost in težave s kostmi Pomembne znake in simptome morate poznati, da boste nanje pozorni med jemanjem zdravila Triumeq.
English: When using the lab-strain HIVIII during passage over 112 days, mutations selected appeared slowly, with substitutions at positions S153Y and F. These mutations were not selected in patients treated with dolutegravir in the clinical studies.
Slovenian: Kadar se pri prehodu skozi 112 dni uprablja laboratorijski sev HIVIII, se izbrane mutacije pojavljajo počasi, z zamenjavami na pozicijah S153Y in F. Te mutacije pri bolnikih, zdravljenih z dolutegravirjem v kliničnih študijah niso bile izbrane.
English: Isolates resistant to abacavir may also show reduced sensitivity to lamivudine.
Slovenian: Izolati, odporni na abakavir, lahko kažejo tudi zmanjšano občutljivost na lamivudin.
English: Abacavir can cause a hypersensitivity reaction (a serious allergic reaction), especially in people who carry a particular type of gene called HLA-B*5701.
Slovenian: Abakavir lahko povzroči preobčutljivostno reakcijo (hudo alergijsko reakcijo), posebno pri ljudeh, ki so nosilci določenega tipa gena, ki se imenuje HLA-B*5701.
English: Based on the above patients are advised to contact their physician immediately to determine whether they should stop taking abacavir if:
Slovenian: Na podlagi zgoraj navedenega bolnikom svetujemo, da se takoj posvetujejo s svojim zdravnikom, ali naj prenehajo jemati abakavir v primeru pojava:
English: Don't stop taking Triumeq unless your doctor advises you to do so.
Slovenian: Ne prenehajte z jemanjem zdravila Triumeq, razen če vam tega ne svetuje zdravnik.
English: Current ART N=278 n (%)
Slovenian: N = 278 n (%)
English: Notes: DRV+RTV = darunavir + ritonavir, DTG = dolutegravir.
Slovenian: Opombe: DRV+RTV = darunavir + ritonavir, DTG = dolutegravir.
English: Studies with abacavir demonstrate a CSF to plasma AUC ratio of between 30 to 44%.
Slovenian: Študije z abakavirjem kažejo, da je razmerje med CST in plazemsko AUC med 30 do 44%.
English: Uncommon suicidal ideation or suicide attempt (particularly in patients with a pre-existing history of depression or psychiatric illness)
Slovenian: samomorilne misli ali poskus samomora (zlasti pri bolnikih z že obstoječo anamnezo depresije ali psihiatričnih bolezni)
English: Triumeq is a fixed-dose tablet and should not be prescribed for patients requiring dose adjustments.
Slovenian: Zdravilo Triumeq je tableta s fiksnim odmerkom, zato se ga ne sme predpisovati bolnikom, pri katerih je potrebno prilagajanje odmerka.
English: Symptoms usually appeared within the first six weeks (median time to onset 11 days) of initiation of treatment with abacavir, although these reactions may occur at any time during therapy.
Slovenian: Simptomi so se običajno pojavili v prvih šestih tednih (mediana časa do pojava je 11 dni) po začetku zdravljenja z abakavirjem, čeprav se te reakcije lahko pojavijo kadar koli med zdravljenjem.
English: Cimetidine
Slovenian: cimetidin
English: M184V is associated with about a 2-fold increase in abacavir resistance but does not confer clinical resistance for abacavir.
Slovenian: M184V je povezan s približno 2-kratnim povečanjem odpornosti na abakavir, vendar ne povzroča klinične odpornosti na abakavir.
English: Missing data during window but on study
Slovenian: Manjkajoči podatki v opazovanem obdobju vendar v študijii
English: • hypersensitivity reaction (see ‘Hypersensitivity reactions' earlier in this section)
Slovenian: • preobčutljivostne reakcije (glejte »Preobčutljivostne reakcije« na začetku tega poglavja)
English: If the patient misses a dose of Triumeq, the patient should take it as soon as possible, providing the next dose is not due within 4 hours.
Slovenian: Če bolnik izpusti odmerek zdravila Triumeq, ga mora vzeti čimprej, pod pogojem, da v naslednjih 4 urah ne vzame že naslednjega odmerka.
English: This medicine contains less than 1 mmol sodium (23 mg) per dosage unit, that is to say essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni »brez natrija«.
English: You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy, so it is important you take your medicine exactly as your doctor has told you.
Slovenian: Med jemanjem tega zdravila lahko še vedno prenesete okužbo z virusom HIV na druge, čeprav učinkovito protiretrovirusno zdravljenje to tveganje zmanjša, zato je pomembno, da pri jemanju tega zdravila natančno upoštevate navodila zdravnika.
English: These have been identified either from clinical studies or post marketing surveillance.
Slovenian: Ugotovljeni so bili bodisi v kliničnih študijah ali v študijah v obdobju trženja zdravila.
English: The use of Triumeq in children under 12 years of age has not yet been studied.
Slovenian: Uporaba zdravila Triumeq pri otrocih, mlajših od 12 let, še ni bila raziskana.
English: Some people taking combination therapy for HIV develop a condition called osteonecrosis.
Slovenian: Pri nekaterih osebah, ki jemljejo kombininacijo zdravil za HIV, se lahko pojavi stanje, imenovano osteonekroza.
English: Symptoms can occur at any time during treatment with ABC, but usually occur within the first 6 weeks of therapy.
Slovenian: Simptomi se lahko pojavijo kadarkoli med zdravljenjem z ABC, a se običajno pojavijo v prvih 6 tednih zdravljenja.
English: Triumeq is used to treat HIV (human immunodeficiency virus) infection in adults and children over 12 years old who weigh at least 40 kg.
Slovenian: Zdravilo Triumeq se uporablja za zdravljenje okužbe z virusom HIV (virus humane imunske pomanjkljivosti) pri odraslih in otrocih, starejših od 12 let, ki tehtajo vsaj 40 kg.
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breastfed infants of mothers treated for HIV are very low (< 4% of maternal serum concentrations) and progressively decrease to undetectable levels when breastfed infants reach 24 weeks of age.
Slovenian: Glede na podatke pri več kot 200 parih mater in otrok, zdravljenih zaradi okužbe HIV, je koncentracija lamivudina v serumu dojenčkov mater, zdravljenih zaradi okužbe s HIV, zelo majhna (manj kot 4 % koncentracije v materinem serumu) in se progresivno zmanjša do nezaznavne ravni, ko dojenček doseže 24 tednov starosti.
English: Fosamprenavir/ritonavir decreases dolutegravir concentrations, but based on limited data, did not result in decreased efficacy in Phase III studies.
Slovenian: Fosamprenavir/ritonavir znižuje koncentracije dolutegravirja, vendar pa po omejenih podatkih v študijah 3. faze ni zmanjšal (njegove) učinkovitosti.
English: If you could get pregnant while receiving Triumeq, you need to use a reliable method of barrier contraception (for example, a condom) with other methods of contraception including oral (pill) or other hormonal contraceptives (for example, implants, injection), to prevent pregnancy.
Slovenian: Če bi lahko med jemanjem zdravila Triumeq zanosili, morate za preprečitev nosečnosti poleg drugih načinov kontracepcije, vključno s peroralnimi (kontracepcijske tablete) ali drugimi hormonskimi kontracepcijskimi sredstvi (na primer vsadki, injekcije), uporabljati zanesljiv način pregradne kontracepcije (na primer kondom).
English: Dolutegravir, abacavir and lamivudine are present in cerebrospinal fluid (CSF).
Slovenian: Dolutegravir, abakavir in lamivudin so prisotni v cerebrospinalni tekočini (CSF).
English: Two mutations conferred a 7 to 8-fold change in abacavir susceptibility and combinations of three mutations were required to confer more than an 8-fold change in susceptibility.
Slovenian: Dve mutaciji sta povzročili 7- do 8-kratno spremembo občutljivosti na abakavir, za več kot 8-kratno spremembo občutljivosti pa so bile potrebne kombinacije treh mutacij.
English: You may need extra check-ups, including blood tests, while you're taking your medicine.
Slovenian: Morda boste med jemanjem tega zdravila potrebovali dodatne preglede, vključno s preiskavami krvi.
English: Hypersensitivity reactions (see section 4.8)
Slovenian: Preobčutljivostne reakcije (glejte poglavje 4.8)
English: Important information about the contents of Triumeq tablets.
Slovenian: Pomembne informacije o sestavi tablet zdravila Triumeq.
English: The majority of these tumours occurred at the highest abacavir dose of 330 mg/kg/day in mice and 600 mg/kg/day in rats.
Slovenian: Do večine omenjenih tumorjev je prišlo pri dajanju najvišjih odmerkov abakavirja, to je 330 mg/kg/dan pri miših in 600 mg/kg/dan pri podganah.
English: When you're being treated for HIV, it can be hard to tell whether a symptom is a side effect of Triumeq or other medicines you are taking, or an effect of the HIV disease itself.
Slovenian: Ko se zdravite zaradi okužbe z virusom HIV, je težko presoditi, ali je nek simptom neželeni učinek zdravila Triumeq ali drugih zdravil, ki jih jemljete, ali pa je posledica same okužbe z virusom HIV.
English: Once the bottle has been opened keep the desiccant in the bottle, do not remove it.
Slovenian: Po odprtju plastenke pustite sušilno sredstvo v njej in ga ne odstranjujte.