FrancophonIA/ELRC3.0 huggingface dataset:
English: The weight of evidence indicates that nelfinavir is unlikely to be a carcinogen in humans.
Slovenian: Glede na rezultate raziskave je zelo malo verjetno, da bi bil nelfinavir za ljudi karcinogen.
English: Some patients taking combination anti-retroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki jemljejo kombinirano protiretrovirusno zdravljenje, se lahko pojavi bolezen kosti, imenovana osteonekroza (odmiranje kostnega tkiva zaradi nezadostne prekrvitve kosti).
English: HMG-CoA reductase inhibitors (statins): HMG-CoA reductase inhibitors may interact with protease inhibitors and increase the risk of myopathy, including rhabdomyolysis.
Slovenian: Zaviralci reduktaze HMG-CoA (statini): zaviralci reduktaze HMG-CoA lahko medsebojno delujejo z zaviralci proteaz in povečajo tveganje za miopatijo, vključno z rabdomiolizo.
English: Ketoconazole
Slovenian: ketokonazol
English: Nelfinavir exposure increases with increasing calorie or fat content of meals taken with VIRACEPT.
Slovenian: Izpostavljenost nelfinavirju narašča s povečanjem števila kalorij ali vsebnostjo maščob v obroku, ki se zaužije skupaj z zdravilom VIRACEPT.
English: Osteonecrosis: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Osteonekroza: čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV in/ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART - combination antiretroviral therapy).
English: • You have a rare blood problem which runs in families called ‘haemophilia'.
Slovenian: • imate redko dedno bolezen krvi, ki se imenuje »hemofilija«,
English: • When your child weighs 18 kg or more, you may provide the tablets either two or three times a day.
Slovenian: • Kadar vaš otrok tehta 18 kg ali več, mu lahko date tablete dvakrat ali trikrat na dan.
English: It is believed that these symptoms are due to an improvement in the body's immune response, enabling the body to fight infections that may have been present
Slovenian: Menijo, da so ti simptomi posledica izboljšanja telesnega imunskega odgovora, ki omogoča telesu, da se brani pred okužbami, ki so bile prej prisotne brez
English: • Rifabutin, erythromycin or clarithromycin (for bacterial infections)
Slovenian: • rifabutin, eritromicin ali klaritromicin (za bakterijske okužbe),
English: If you stop taking Viracept
Slovenian: Če ste prenehali jemati zdravilo Viracept
English: Administration of 300 mg/kg/day resulted in an increased incidence of thyroid follicular cell adenoma.
Slovenian: Dajanje 300 mg/kg/dan je povzročilo porast pogostnosti folikularnega celičnega adenoma ščitnice.
English: Nelfinavir is also an inhibitor of CYP 3A4.
Slovenian: Nelfinavir je tudi zaviralec CYP 3A4.
English: The use of nelfinavir in patients with moderate hepatic impairment has not been studied.
Slovenian: Uporabe nelfinavirja pri bolnikih z zmerno jetrno okvaro niso proučevali.
English: The pharmacokinetic properties of nelfinavir have been evaluated in healthy volunteers and HIV-infected patients.
Slovenian: Farmakokinetične lastnosti nelfinavirja so proučevali pri zdravih prostovoljcih in pri s HIV okuženih bolnikih.
English: A total of approximately 400 patients received nelfinavir in paediatric treatment trials (Studies 524, 556, PACTG 377/725, and PENTA-7) for up to 96 weeks.
Slovenian: V študijah zdravljenja pediatričnih bolnikov (študije 524, 556, PACTG 377/725 in PENTA-7) je nelfinavir v celoti prejemalo približno 400 bolnikov do 96 tednov.
English: The combination may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations and sinus tachycardia.
Slovenian: Kombinacija lahko povzroči povečano tveganje za kardiovaskularne neželene dogodke, povezane s salmeterolom, vključno z podaljšanim QT, palpitacijami in sinusno tahikardijo.
English: • White 1 gram (1g) scoop.
Slovenian: • Bela merica po 1 gram (1 g).
English: Carcinogenicity: Two year oral carcinogenicity studies with nelfinavir mesilate were conducted in mice and rats.
Slovenian: Karcinogenost: pri miših in podganah so izvedli dvoletne študije karcinogenosti s peroralnim nelfinavirjevim mesilatom.
English: Increased alanine aminotransferase, increased aspartate aminotransferase, neutropenia, blood creatinine phosphokinase increased, neutrophil count decreased
Slovenian: Preiskave pogosti povečana alanin aminotransferaza, povečana aspartat aminotransferaza, nevtropenija, povečana keratinin fosfokinaza, znižano število nevtrofilcev
English: Concomitant use of sildenafil prescribed for the treatment of pulmonary arterial hypertension with VIRACEPT is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba sildenafila, predpisanega za zdravljenje pljučne arterijske hipertenzije, z zdravilom VIRACEPT je kontraindicirana (glejte poglavje 4.3).
English: The glass should be rinsed with a half cup of water and the rinse should be swallowed to ensure that the entire dose is consumed.
Slovenian: Kozarec je treba poplakniti s pol kozarca vode in jo popiti, saj s tem zagotovimo, da se zaužije celoten odmerek.
English: Do not stop taking this medicine without talking to your doctor first.
Slovenian: Zdravila ne smete prenehati jemati brez predhodnega posvetovanja z vašim zdravnikom.
English: This helps your body to get the full benefit from your
Slovenian: Na ta način bo vaše telo dobilo največ koristi od
English: Patients with chronic hepatitis B or C and treated with anti-retroviral agents are at increased risk for severe and potentially fatal liver adverse events and may require blood tests for control of liver function.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki se zdravijo s protiretrovirusnimi zdravili, obstaja zvečano tveganje za hude in potencialno smrtne jetrne neželene dogodke, zato bodo morda potrebni krvni testi za nadzor jetrnega delovanja.
English: 144 g Oral powder
Slovenian: 144 g peroralnega praška
English: Adverse reactions from clinical trials with nelfinavir
Slovenian: Neželeni učinki iz kliničnih študij z nelfinavirjem
English: Viracept TID (%)
Slovenian: Viracept trikrat na dan (%)
English: Combination of simvastatin or lovastatin and nelfinavir is contraindicated (see contraindication).
Slovenian: Kombinacija simvastatina ali lovastatina in nelfinavirja je kontraindicirana (glejte kontraindikacije).
English: • The active substance in Viracept is nelfinavir.
Slovenian: • Zdravilna učinkovina zdravila Viracept je nelfinavir.
English: An HIV isolate obtained from a patient receiving saquinavir therapy showed decreased susceptibility to saquinavir (7- fold) but did not demonstrate a concordant decrease in susceptibility to nelfinavir.
Slovenian: Pri izolatu HIV, ki so ga pridobili od bolnika, ki je prejemal zdravljenje s sakvinavirjem, so opazili zmanjšano občutljivost za sakvinavir (7-krat), niso pa opazili zmanjšane občutljivosti za nelfinavir.
English: • Ketoconazole, itraconazole or fluconazole (for fungal infections)
Slovenian: • ketokonazol, itrakonazol ali flukonazol (za glivične okužbe),
English: In vivo: The overall incidence of the D30N mutation in the viral protease of assessable isolates (n=157) from patients receiving nelfinavir monotherapy or nelfinavir in combination with zidovudine and lamivudine or stavudine was 54.8 %.
Slovenian: In vivo: skupna incidenca mutacije D30N virusne proteaze ocenljivih izolatov (n = 157) bolnikov, ki so prejemali samostojno zdravljenje z nelfinavirjem ali nelfinavir v kombinaciji z zidovudinom in lamivudinom ali stavudinom, je bila 54,8 %.
English: These may include loss of fat from legs, arms and face, increased fat in the abdomen (belly) and other internal organs, breast enlargement and fatty lumps on the back of the neck (‘buffalo hump').
Slovenian: Spremembe lahko zajemajo izgubo maščevja na nogah, rokah in obrazu, povečanje maščevja v abdomnu (trebuhu) in drugih notranjih organih, povečanje prsi in maščobne kepe na zadnjem delu vratu (bivolja grba).
English: Clinical pharmacodynamic data: treatment with nelfinavir alone or in combination with other antiretroviral agents has been documented to reduce viral load and increase CD4 cell counts in HIV-1 seropositive patients.
Slovenian: Klinični farmakodinamični podatki: zdravljenje s samim nelfinavirjem ali v kombinaciji z drugimi protiretrovirusnimi učinkovinami dokazano zmanjšuje virusno obremenitev in poveča število celic CD4 pri HIV-1 seropozitivnih bolnikih.
English: PDE5 inhibitors: particular caution should be used when prescribing sildenafil, tadalafil or vardenafil for the treatment of erectile dysfunction in patients receiving VIRACEPT.
Slovenian: Zaviralci PDE-5: pri predpisovanju sildenafila, tadalafila ali verdenafila za zdravljenje erektilne disfunkcije pri bolnikih, ki prejemajo zdravilo VIRACEPT, je potrebna posebna previdnost.
English: Neutropenia/leukopenia was the most frequently observed laboratory abnormality.
Slovenian: Najpogosteje opažena laboratorijska nenormalnost je bila nevtropenija/levkopenija.
English: Excipients: - Contains sucrose palmitate: 10.0 mg per gram of oral powder.
Slovenian: Pomožne snovi: - vsebuje saharozo palmitat: 10,0 mg na gram peroralnega praška.
English: Of 19 patients for whom both phenotypic and genotypic analyses were performed on clinical isolates, 9 patients isolates showed reduced susceptibility (5- to 93-fold) to nelfinavir in vitro.
Slovenian: Od 19 bolnikov, za katere so na kliničnih izolatih opravili fenotipske in genotipske analize, se je pri 9 izolatih bolnikov pokazala zmanjšana občutljivost (5- do 93-krat) na nelfinavir v in vitro.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu/.
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/, kjer lahko najdete tudi povezave do drugih spletnih strani o redkih boleznih in zdravljenju.
English: Roche Pharma AG Emil-Barell-Strasse 1 D-79639 Grenzach-Wyhlen Germany
Slovenian: Roche Pharma AG Emil-Barell-Strasse 1 D-79639 Grenzach/Wyhlen Nemčija
English: CONDITIONS OF THE MARKETING AUTHORISATION
Slovenian: B. POGOJI DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: • This medicine contains sucrose, which is a type of sugar.
Slovenian: • Zdravilo vsebuje vrsto sladkorja, saharozo.
English: Sedatives/Anxiolytics Midazolam
Slovenian: Sedativi/anksiolitiki midazolam
English: Bone disease (osteonecrosis)
Slovenian: Bolezni skeletnega sistema (osteonekroza)
English: ↑ Fluticasone
Slovenian: ↑ flutikazon
English: • Terfenadine or astemizole (for allergy)
Slovenian: • terfenadin ali astemizol (za alergijo),
English: All patients older than 13 years should take either 5 level scoops of the blue 5 gram spoon twice daily or 3 level scoops of the blue 5 gram spoon three times daily.
Slovenian: Vsi bolniki, starejši od 13 let, morajo vzeti ali 5 poravnanih modrih 5-g meric dvakrat na dan ali 3 poravnane modre 5-g merice praška trikrat na dan.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 January 1998
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 22.1.1998
English: Viracept tablets can be taken either two or three times a day with a meal.
Slovenian: Zdravilo Viracept tablete se lahko vzame bodisi dvakrat ali trikrat na dan z obrokom.
English: Coadministration of nelfinavir with omeprazole may lead to a loss of virologic response and therefore concomitant use is contraindicated.
Slovenian: Sočasna uporaba nelfinavirja in omeprazola lahko povzroči izgubo virološkega odziva, zato je kontraindicirana.
English: Monitoring of overdosed patients is warranted.
Slovenian: Bolnike, ki so zaužili prevelike odmerke zdravila, je smiselno spremljati.
English: Based on data for other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally.
Slovenian: Na osnovi podatkov drugih zaviralcev CYP3A4 je pričakovati, da bodo plazemske koncentracije midazolama značilno višje pri peroralnem dajanju midazolama.
English: Co-administration of VIRACEPT with these medicinal products is expected to increase their concentrations and may result in associated adverse events such as hypotension, syncope, visual changes and prolonged erection (see section 4.5).
Slovenian: Pri sočasno danem zdravilu VIRACEPT s temi zdravili se pričakuje, da se bo njihova koncentracija povečala, kar lahko privede do z njimi povezanih neželenih učinkov kot so hipotenzija, sinkopa, spremembe vida in podaljšanje erekcije (glejte poglavje 4.5).
English: Dosing Regimen1 N2
Slovenian: Režim odmerjanja1
English: Nelfinavir reversibly binds to the active site of HIV protease and prevents cleavage of the polyproteins resulting in the formation of immature non-infectious viral particles.
Slovenian: Nelfinavir se reverzibilno veže na aktivno mesto HIVproteaze in prepreči cepitev polibeljakovin, kar povzroči nastanek nezrelih neinfektivnih virusnih delcev.
English: PDE-5 inhibitors for the treatment of erectile dysfunction (ED) Tadalafil
Slovenian: Zaviralec PDE-5 za zdravljenje erektilne disfunkcije (ED) tadalafil
English: There were no significant differences between low doses of ritonavir (either 100 or 200 mg BID) for effects on AUCs of nelfinavir and M8.
Slovenian: Med nizkimi odmerki ritonavirja (100 ali 200 mg dvakrat na dan) ni bilo klinično značilnih razlik glede učinkov na AUC nelfinavirja in M8.
English: • Store in the original container.
Slovenian: • Shranjujte v originalnem vsebniku.
English: Resistance: Viral escape from nelfinavir can occure via viral protease mutations at amino acid positions 30, 88 and 90.
Slovenian: Odpornost: virus se lahko izogne učinku nelfinavirja s pomočjo mutacij virusne proteaze na aminokislinskih mestih 30, 88 in 90.
English: A connection between visceral lipomatosis and PIs and lipoatrophy and nucleoside analogue reverse transcriptase inhibitors (NRTIs) has been hypothesised.
Slovenian: Obstajajo hipoteze o povezavi med visceralno lipomatozo in PI ter lipoatrofijo in nukleozidnimi analogi zaviralcev reverzne transkriptaze (NRTI - “nucleoside analogue reverse transcriptase inhibitors”).
English: H1 Receptor Antagonists, 5-HT Agonists Terfenadine, astemizole, cisapride Nelfinavir increases terfenadine
Slovenian: Antagonisti receptorjev H1, agonisti 5-HT terfenadin, astemizol, cisaprid Nelfinavir poveča plazemske
English: • Medicines made from ergot such as cabergoline, ergotamine or lisuride (for Parkinson's disease or migraine)
Slovenian: • zdravila iz derivatov ergot, kot so kabergolin, ergotamin ali lizurid (za Parkinsonovo bolezen ali migreno),
English: Renal Impairment: Since nelfinavir is highly bound to plasma proteins, it is unlikely that it will be significantly removed by haemodiaylisis or peritoneal dialysis.
Slovenian: Ledvična okvara: ker se nelfinavir močno veže na plazemske proteine, je malo verjetno, da se pomembno izloča s hemodializo ali peritonalno dializo.
English: Do not take Viracept and tell your doctor or pharmacist if you are taking any of the following medicines:
Slovenian: Ne jemljite zdravila Viracept in obvestite svojega zdravnika ali farmacevta, če jemljete katerokoli od navedenih zdravil:
English: Amino acid position 30 appeared to be the most frequent mutation site.
Slovenian: Najpogostejše mesto mutacije je bilo aminokislinsko mesto 30.
English: If you want to take the tablets instead please see the Package Leaflet for Viracept 250 mg tablets.
Slovenian: Če želite namesto praška jemati tablete, prosimo, glejte Navodilo za uporabo za zdravilo Viracept 250 mg tablete.
English: • Colchicine (for gout-flares or Mediterranean fever)
Slovenian: • kolhicin ( za zdravljenje putike ali Mediteranske vročine),
English: The prescriber should also advise the caregiver about the importance of adhering to the dosing instructions and that the appropriate number of tablets should be taken at each dose with a meal.
Slovenian: Predpisovalec zdravila mora osebi, ki skrbi za bolnika prav tako razložiti, kako pomembno je, da se upoštevajo navodila za odmerjanje ter da se pravilno število tablet vzame pri vsakem odmerku ob obroku.
English: Nelfinavir is primarily metabolised via the cytochrome P450 isoenzymes CYP3A4 and CYP2C19 (see section 5.2).
Slovenian: Nelfinavir se v glavnem presnavlja z izoencimi CYP3A4 in CYP2C19 citokroma P450 (glejte poglavje 5.2).
English: Ultrasensitive
Slovenian: Zelo občutljive
English: Clinical experience in pregnant women is limited.
Slovenian: Klinične izkušnje z uporabo zdravila VIRACEPT pri nosečnicah so pomanjkljive.
English: Taking Viracept with food and drink Take Viracept with a meal.
Slovenian: Jemanje zdravila Viracept skupaj s hrano in pijačo Zdravilo Viracept zaužijte z obrokom.
English: The clinical relevance of these in vitro data is unknown.
Slovenian: Klinična pomembnost teh in vitro ugotovitev ni znana.
English: The safety of the combination indinavir + nelfinavir has not been established
Slovenian: Varnosti kombinacije indinavirja in nelfinavirja niso ugotovili.
English: In protease inhibitor (PI) experienced patients the choice of nelfinavir should be based on individual viral resistance testing and treatment history.
Slovenian: Izbira nelfinavirja pri bolnikih, že zdravljenih z zaviralci proteaz (PI - “protease inhibitor”), mora biti osnovana na testiranju virusne odpornosti posameznika in predhodnega zdravljenja.
English: Caution is recommended when nelfinavir is co-administered with other proton pump inhibitors
Slovenian: Previdnost je potrebna, ko se nelfinavir jemlje skupaj z drugimi zaviralci protonske črpalke.
English: • Fluoxetine, paroxetine, imipramine, amitriptyline or trazodone (for depression)
Slovenian: • fluoksetin, paroksetin, imipramin in amitriptilin ali trazodon (za depresijo),
English: Other HMG-CoA reductase inhibitors may also interact with protease inhibitors and should be used with caution .
Slovenian: Drugi zaviralci reduktaze HMG-CoA lahko prav tako medsebojno delujejo z zaviralci proteaz in se morajo uporabljati s previdnostjo.
English: The clinical relevance of relating in vitro measures to drug potency and clinical outcome has not been established.
Slovenian: Klinične pomembnosti povezave med in vitro meritvami učinkovitosti zdravila in kliničnim izidom niso ugotovili.
English: Cross resistance in vitro: HIV isolates obtained from 5 patients during nelfinavir therapy showed a 5- to 93-fold decrease in nelfinavir susceptibility in vitro when compared to matched baseline isolates but did not demonstrate a concordant decrease in susceptibility to indinavir, ritonavir, saquinavir or amprenavir in vitro.
Slovenian: Navzkrižna odpornost in vitro: pri izolatih HIV, ki so jih pridobili od 5 bolnikov med zdravljenjem z nelfinavirjem, so odkrili 5- do 93-krat manjšo občutljivost za nelfinavir v in vitro v primerjavi z izolati ob začetku zdravljenja, niso pa odkrili skladnega zmanjšanja občutljivosti za indinavir, ritonavir, sakvinavir ali amprenavir in vitro.
English: The major oxidative metabolite, M8 (tertbutyl hydroxy nelfinavir), has in vitro antiviral activity equal to the parent drug and its formation is catalysed by the polymorphic cytochrome CYP2C19.
Slovenian: Glavni oksidirani presnovek, M8 (terc-butil hidroksinelfinavir), ima in vitro enako protivirusno aktivnost kot učinkovina, njegovo tvorbo katalizira polimorfni citokrom CYP2C19.
English: In addition, an updated RMP should be submitted
Slovenian: Poleg tega je treba predložiti posodobljen načrt za obvladovanje tveganja:
English: If you notice any of the above, contact your doctor straight away.
Slovenian: Če opazite karkoli od zgoraj navedenega, takoj obvestite svojega zdravnika.
English: • Table 2: if you give the medicine two times a day (for children who weigh 18 kg or more), you will give 50-55 mg nelfinavir each time for each kg of body weight.
Slovenian: • Preglednica 2: če dajete zdravilo dvakrat na dan (otrokom, ki tehtajo 18 kg ali več), potem boste vsakič dali 50-55 mg nelfinavirja za vsak kg telesne mase.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse events.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki jih zdravimo s kombiniranim protiretrovirusnim zdravljenjem, obstaja povečano tveganje za razvoj hudih in potencialno smrtnih jetrnih neželenih dogodkov.
English: • Do not add liquid to the powder in its original container
Slovenian: • Praška ne smete mešati s tekočino v originalnem vsebniku.
English: • Once the tablet is dispersed, mix the cloudy bluish liquid thoroughly and take immediately.
Slovenian: • ko se tableta raztopi temeljito premešajte motno modrikasto tekočino in takoj popijte,
English: A second study evaluated the steady state pharmacokinetics of nelfinavir (1250 mg twice daily for 2 weeks) in adult HIV-seronegative subjects with mild (Child-Pugh A; n=6) or moderate (Child-Pugh B; n=6) hepatic impairment.
Slovenian: V drugi študiji so ocenjevali farmakokinetiko nelfinavirja v stanju dinamičnega ravnovesja (1250 mg dvakrat na dan 2 tedna) pri odraslih HIV seronegativnih osebah z blago (ChildPugh A; n=6) ali zmerno (Child-Pugh B; n=6) jetrno okvaro.
English: Blue, oblong biconvex film-coated tablets.
Slovenian: Modre podolgovate, bikonveksne filmsko obložene tablete.
English: Plasma levels of certain HIV-1 protease inhibitors, which are metabolised predominantly by CYP3A4, can be increased by the co-administration of low-dose ritonavir, which is an inhibitor of this metabolism.
Slovenian: Plazemske koncentracije nekaterih zaviralcev HIV-1 proteaze, ki se presnavljajo pretežno s CYP3A4, se lahko povišajo s sočasnim dajanjem majhnih odmerkov ritonavirja, ki je zaviralec te presnove.
English: Also contains sweetener aspartame (E951), sucrose palmitate, potassium, natural and artificial flavourings and other constituents.
Slovenian: Vsebuje tudi sladilo aspartam (E951), saharozo palmitat, kalij, naravne in umetne arome in druge pomožne snovi.
English: If you want to take the powder instead please see the Package Leaflet for Viracept 50 mg/g oral powder.
Slovenian: Če želite namesto tablet jemati prašek, prosimo, glejte Navodilo za uporabo za zdravilo Viracept 50 mg/g peroralni prašek.
English: If treatment with HMG-CoA reductase inhibitors is indicated in combination with nelfinavir, pravastatin or fluvastatin are recommended.
Slovenian: Če je potrebno zdravljenje z zaviralci HMG-CoA reduktaze, se priporočata pravastatin ali fluvastatin.
English: Conversely, following ritonavir therapy, 6 of 7 clinical isolates with decreased ritonavir susceptibility (8- to 113-fold) in vitro compared to baseline also exhibited decreased susceptibility to nelfinavir in vitro (5- to 40 fold).
Slovenian: Nasprotno pa so po zdravljenju z ritonavirjem pri 6 od 7 kliničnih izolatov z zmanjšano občutljivostjo za ritonavir (8- do 113-krat) in vitro v primerjavi z izolati na začetku zdravljenja opazili tudi zmanjšano občutljivost za nelfinavir in vitro (5- do 40-krat).
English: Two measuring scoops are provided in the medicine box:
Slovenian: Kako pripraviti zdravilo Viracept V škatli sta dve merici:
English: • Alfuzosin (for benign prostatic hyperplasia (BPH))
Slovenian: • alfuzosin (za zdravljenje benigne hiperplazije prostate (BHP)),
English: Potent inducers of CYP3A (e.g., rifampicin, phenobarbital and carbamazepine) reduce nelfinavir plasma concentrations.
Slovenian: Močni induktorji CYP3A (npr. rifampicin, fenobarbital in karbamazepin) zmanjšajo plazemske koncentracije nelfinavirja.