FrancophonIA/ELRC3.0 huggingface dataset:
English: Before you drive a vehicle, use tools or operate machines, or carry out other activities that require concentration, make sure you know how Neparvis affects you.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Preden začnete voziti, uporabljati orodje, upravljati stroje ali izvajati druge dejavnosti, ki zahtevajo zbranost, morate zagotovo vedeti, kako zdravilo Neparvis deluje na vas.
English: The median follow-up duration was 27 months and patients were treated for up to 4.3 years.
Slovenian: Spremljanje bolnikov je trajalo mediano 27 mesecev, bolniki pa so bili zdravljeni največ 4,3 leta.
English: No significant interaction
Slovenian: Zdravila brez pomembnih interakcij
English: Other preclinical findings
Slovenian: Druge predklinične ugotovitve
English: What you need to know before you take Neparvis
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Neparvis
English: If this happens, your doctor may reduce the dose of any other medicine you are taking, temporarily reduce your Neparvis dose, or stop your Neparvis treatment completely.
Slovenian: Če pride do navedenega, vam zdravnik lahko zniža odmerek katerega od drugih zdravil, ki jih jemljete, začasno zniža odmerek zdravila Neparvis ali pa vam dokončno ukine zdravljenje z zdravilom Neparvis.
English: • if you have low blood pressure or are taking any other medicines that reduce your blood pressure (for example, a diuretic) or are suffering from vomiting or diarrhoea, especially if you are aged 65 years or more, or if you have kidney disease and low blood pressure.
Slovenian: • če imate nizek krvni tlak ali jemljete katero od drugih zdravil, ki znižujejo krvni tlak (na primer diuretike - zdravila za odvajanje vode) ali če bruhate ali imate drisko, zlasti če ste stari 65 let ali več ali če imate bolezen ledvic in nizek krvni tlak.
English: In general no dose adjustment is required.
Slovenian: Prilagajanje odmerkov načeloma ni potrebno.
English: Appropriate care should be exercised when initiating or ending concomitant treatment with such medicinal products.
Slovenian: Pri uvedbi ali ukinjanju sočasnega zdravljenja s takšnimi zdravili je zato potrebna ustrezna pozornost.
English: Evaluation of patients with heart failure should always include assessment of renal function.
Slovenian: Pregled bolnikov s popuščanjem srca mora vedno vključevati oceno ledvične funkcije.
English: Within each frequency grouping, adverse reactions are ranked in order of decreasing seriousness.
Slovenian: V vsaki skupini pogostnosti so neželeni učinki navedeni po padajoči resnosti.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Neparvis in one or more subsets of the paediatric population in the treatment of heart failure (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Neparvis za eno ali več podskupin pediatrične populacije za zdravljenje srčnega popuščanja (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Interactions requiring precautions
Slovenian: Interakcije, zaradi katerih je potrebna previdnost
English: While there was no relevant change in urine volume, the urinary excretion of sodium was reduced within 4 hours and 24 hours after co-administration.
Slovenian: Volumen izločenega urina se ni bistveno spremenil, izločanje natrija z urinom pa se je zmanjšalo v času od 4 do 24 ur po sočasnem odmerjanju.
English: A hydroxyl metabolite of valsartan has been identified in plasma at low concentrations (<10%).
Slovenian: V plazmi so odkrili hidroksilni presnovek valsartana v nizki koncentraciji (<10 %).
English: These reach peak plasma concentrations in 2 hours, 1 hour, and 2 hours, respectively.
Slovenian: Navedene snovi dosežejo najvišjo koncentracijo v plazmi v 2 urah, v 1 uri oziroma v 2 urah.
English: When initiating therapy or during dose titration with Neparvis, blood pressure should be monitored routinely.
Slovenian: Ob začetku zdravljenja oziroma med titriranjem odmerka zdravila Neparvis je treba rutinsko spremljati krvni tlak.
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system; angiotensin II antagonists, other combinations, ATC code: C09DX04
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na renin-angiotenzinski sistem; antagonisti angiotenzina II, druge kombinacije, oznaka ATC: C09DX04
English: • dizziness when switching from sitting to standing position
Slovenian: • omotičnost pri vstajanju iz sedečega položaja
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however, a small increase in risk cannot be excluded.
Slovenian: Epidemiološki podatki niso prepričljivo potrdili tveganja za teratogeno delovanje pri nosečnicah, ki so bile v prvem trimesečju nosečnosti izpostavljene zaviralcem ACE, vendar pa majhnega povečanja tveganja ni možno izključiti.
English: Neparvis does not induce or inhibit CYP450 enzymes.
Slovenian: Zdravilo Neparvis niti ne inducira niti ne zavira encimov CYP450.
English: At randomisation, 70% of patients were NYHA class II, 24% were class III and 0.7% were class IV.
Slovenian: Ob randomizaciji je imelo 70 % bolnikov srčno popuščanje razreda II, 24 % razreda III in 0,7 % razreda IV po klasifikaciji NYHA.
English: Other medicines and Neparvis Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.
Slovenian: Druga zdravila in zdravilo Neparvis Obvestite zdravnika, farmacevta ali medicinsko sestro, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
English: Caution is therefore recommended when using it in these patients (see section 4.2 and 5.2).
Slovenian: Pri uporabi zdravila pri teh bolnikih je torej potrebna previdnost (glejte poglavji 4.2 in 5.2).
English: The recommended starting dose of Neparvis is one tablet of 49 mg/51 mg twice daily, except in the situations described below.
Slovenian: Priporočeni začetni odmerek zdravila Neparvis je ena tableta 49 mg/51 mg dvakrat na dan, razen v spodaj opisanih primerih.
English: • Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Slovenian: • Preobčutljivost na učinkovini ali katero koli pomožno snov, navedeno v poglavju 6.1.
English: ACE inhibitors are used to treat high blood pressure or heart failure.
Slovenian: Zaviralce ACE uporabljamo za zdravljenje visokega krvnega tlaka ali srčnega popuščanja.
English: Table 2 Treatment effect for the primary composite endpoint, its components and all-cause mortality over a median follow-up of 27 months
Slovenian: Preglednica 2 Učinek zdravljenja na sestavljeni primarni cilj opazovanja v celoti, na njegove posamezne dogodke in na umrljivost iz kateregakoli vzroka v času spremljanja, ki je mediano trajalo 27 mesecev
English: Because of the potential risk for adverse reactions in breast-fed newborns/infants, it is not recommended during breast-feeding.
Slovenian: Zaradi možnega tveganja za neželene učinke na dojene novorojence/otroke uporaba zdravila v času dojenja ni priporočena.
English: • furosemide, a medicine belonging to the type known as diuretics, which are used to increase the amount of urine you produce.
Slovenian: • furosemida, zdravila, ki sodi med diuretike, ki jih uporabljamo za povečevanje količine urina, ki nastaja v telesu.
English: PARADIGM-HF
Slovenian: Študija PARADIGM-HF
English: If angioedema occurs, Neparvis should be immediately discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred.
Slovenian: Če pride do angioedema, je treba zdravljenje z zdravilom Neparvis takoj prekiniti in poskrbeti za ustrezno zdravljenje in spremljanje bolnika, dokler znaki in simptomi angioedema niso v celoti in trajno odpravljeni.
English: It is not known whether Neparvis is excreted in human milk.
Slovenian: Ni znano, ali se zdravilo Neparvis izloča v materino mleko.
English: Novartis Pharma GmbH Roonstrasse 25
Slovenian: Novartis Pharma GmbH Roonstraße 25
English: • some medicines known as statins that are used to lower high cholesterol levels (for example atorvastatin).
Slovenian: • nekaterih zdravil iz skupine imenovane statini, ki jih uporabljamo za zniževanje previsoke ravni holesterola (na primer atorvastatin).
English: If you are taking one of these, your doctor may want to check your kidney function when starting or adjusting treatment (see “Warnings and precautions”).
Slovenian: Če jemljete katero od teh zdravil, bo zdravnik verjetno preverjal delovanje vaših ledvic ob začetku zdravljenja in ob spremembah odmerkov (glejte pod naslovom "Opozorila in previdnostni ukrepi").
English: A study in adult rats showed only a minimal transient inhibitory effect on bone mineral density but not on any other parameters relevant for bone growth, suggesting no relevant effect of sacubitril on bone in adult patient populations under normal conditions.
Slovenian: Rezultati raziskave pri odraslih podganah kažejo le manjši in prehoden zaviralni vpliv na mineralno kostno gostoto, na druge parametre, ki so pomembni za rast kosti, pa ne, kar bi lahko kazalo na to, da sakubitril v populaciji odraslih bolnikov v običajnih pogojih ne vpliva bistveno na kosti.
English: OUTER CARTON OF MULTIPACK (INCLUDING BLUE BOX)
Slovenian: ZUNANJA ŠKATLA SKUPNEGA PAKIRANJA (VKLJUČNO Z "BLUE BOX" PODATKI)
English: *See description of selected adverse reactions.
Slovenian: * glejte opis izbranih neželenih učinkov Opis izbranih neželenih učinkov
English: If a diuretic is also used, the risk of lithium toxicity may be increased further.
Slovenian: Če bolnik uporablja tudi diuretik, je lahko tveganje za toksično delovanje dodatno povečano.
English: The most common symptoms of heart failure are breathlessness, fatigue, tiredness and ankle swelling.
Slovenian: Najbolj pogosti simptomi srčnega popuščanja so zadihanost, izčrpanost, utrujenost in otekanje gležnjev.
English: • if you or a member of your family have ever had a reaction called angioedema (swelling of the face, lips, tongue and/or throat, difficulties in breathing) when taking an ACE inhibitor or an angiotensin receptor blocker (ARB) (such as valsartan, telmisartan or irbesartan).
Slovenian: • če ste imeli kadarkoli sami ali je imel kdo iz vaše družine reakcijo, ki jo imenujemo angioedem (otekanje obraza, ustnic, jezika in/ali grla oziroma žrela, oteženo dihanje) v času jemanja zaviralca ACE ali zaviralca angiotenzinskih receptorjev (kot so valsartan, telmisartan ali irbesartan).
English: The AT1-receptor was also blocked as evidenced by increased plasma renin activity and plasma renin concentrations.
Slovenian: Blokirani so bili tudi receptorji AT1, kar je dokazovalo povečanje aktivnosti renina v plazmi in zvišanje koncentracije renina v plazmi.
English: Overall, 76% of patients achieved and maintained the target dose of Neparvis 200 mg twice daily without any dose interruption or down-titration over 12 weeks.
Slovenian: Skupno je 76 % bolnikov doseglo in vztrajalo pri prejemanju ciljnega odmerka 200 mg zdravila Neparvis dvakrat na dan brez prekinitve odmerjanja ali zniževanja odmerka v obdobju 12 tednov.
English: • allergic reaction with rash and itching
Slovenian: • alergijska reakcija z izpuščajem in srbežem
English: Your doctor will normally advise you to stop taking this medicine before you become pregnant or as soon as you know you are pregnant, and will advise you to take another medicine instead of Neparvis.
Slovenian: Zdravnik vam bo načeloma svetoval, da prenehate jemati to zdravilo, prede zanosite ali takoj, ko ugotovite, da ste noseči.
English: Dose adjustment of diuretics, concomitant antihypertensives and treatment of other causes of hypotension (e.g. hypovolaemia) should be considered.
Slovenian: Razmisliti je treba o prilagajanju odmerjanja diuretikov, sočasno uporabljanih antihipertenzivov in odpravljanju drugih vzrokov hipotenzije (na primer hipovolemije).
English: Sodium and/or volume depletion should be corrected before starting treatment with Neparvis, however, such corrective action must be carefully weighed against the risk of volume overload.
Slovenian: Pomanjkanje natrija in/ali hipovolemijo je treba odpraviti pred začetkom zdravljenja z zdravilom Neparvis, vendar je pri izvajanju takšnih korektivnih ukrepov potreben skrben razmislek zaradi tveganja za volumsko preobremenitev.
English: Hazard ratio (95% CI)
Slovenian: razmerje ogroženosti (95-odstotni IZ)
English: Use of Neparvis may be associated with decreased renal function.
Slovenian: Uporaba zdravila Neparvis je lahko povezana z zmanjšanim delovanjem ledvic.
English: 14 film-coated tablets 20 film-coated tablets 28 film-coated tablets 56 film-coated tablets
Slovenian: 14 filmsko obloženih tablet 20 filmsko obloženih tablet 28 filmsko obloženih tablet 56 filmsko obloženih tablet
English: There are no data from the use of sacubitril in pregnant women.
Slovenian: O uporabi sakubitrila pri nosečnicah ni na voljo nobenih podatkov.
English: Patients randomised to the Neparvis group received treatment for a median duration of exposure of 24 months; 3,271 patients were treated for more than one year.
Slovenian: Bolniki, ki so jih randomizirali v skupino z zdravilom Neparvis, so zdravilo prejemali z medianim trajanjem izpostavljenosti zdravilu 24 mesecev, pri tem pa je 3.271 bolnikov prejemalo zdravilo več kot eno leto.
English: However, if you forget to take a dose, you should simply take the next one at the scheduled time.
Slovenian: Če kljub temu pozabite vzeti odmerek, enostavno vzemite samo naslednji odmerek po razporedu.
English: There was no drug-drug interaction between Neparvis and intravenously administered nitroglycerin with regard to blood pressure reduction.
Slovenian: Med zdravilom Neparvis in intravensko apliciranim nitroglicerinom ni bilo nobenih interakcij, povezanih z znižanjem krvnega tlaka.
English: Your doctor will decide your exact starting dose based on which medicines you have been taking previously.
Slovenian: Točen odmerek, s katerim boste začeli zdravljenje, bo določil zdravnik na podlagi tega, katera zdravila ste jemali pred tem.
English: Interactions resulting in a contraindication
Slovenian: Interakcije, ki so razlog za kontraindikacije
English: • gastritis (stomach pain, nausea)
Slovenian: • gastritis (bolečine v želodcu, občutek slabosti)
English: Prior to study participation, patients were well treated with standard of care therapy which included ACE inhibitors/ARBs (>99%), beta blockers (94%), mineralocorticoid antagonists (58%) and diuretics (82%).
Slovenian: Pred vključitvijo v študijo so bili bolniki ustrezno zdravljeni z zdravili, ki predstavljajo standard zdravljenja, med drugim z zaviralci ACE/angiotenzinskih receptorjev (>99 %), antagonisti adrenergičnih receptorjev beta (94 %), antagonisti mineralokortikoidov (58 %) in diuretiki (82 %).
English: Sacubitril
Slovenian: Sakubitril
English: The exposure of valsartan was similar in patients with moderate and severe renal impairment compared to patients with mild renal impairment.
Slovenian: Izpostavljenost valsartanu je bila pri bolnikih z zmerno in hudo okvaro ledvic približno enaka kot pri bolnikih z blago okvaro ledvic.
English: If you stop taking Neparvis
Slovenian: Če ste prenehali jemati zdravilo Neparvis
English: • sildenafil, a medicine used to treat erectile dysfunction or lung hypertension.
Slovenian: • sildenafila, zdravila, ki ga uporabljamo za zdravljenje erektilne disfunkcije ali pljučne hipertenzije.
English: If you have accidentally taken too many Neparvis tablets, or if someone else has taken your tablets, contact your doctor immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Neparvis, kot bi smeli Če ste pomotoma vzeli preveč tablet zdravila Neparvis ali če je vaše tablete zaužil kdo drug, takoj obvestite zdravnika.
English: If you forget to take Neparvis
Slovenian: Če ste pozabili vzeti zdravilo Neparvis
English: If you think you may be allergic to any component of this medicine, talk to your doctor before taking Neparvis.
Slovenian: Če mislite, da bi lahko bili alergični na katero od sestavin tega zdravila, se posvetujte z zdravnikom, preden začnete jemati zdravilo Neparvis.
English: Tell your doctor if you are breastfeeding or about to start breastfeeding.
Slovenian: Zdravniku povejte, če dojite ali nameravate začeti z dojenjem.
English: Max. daily dose (mg)
Slovenian: Učinkovina* Največji dnevni odmerek (mg)
English: Angioedema associated with laryngeal oedema may be fatal.
Slovenian: Angioedem povezan z edemom grla je lahko smrten.
English: A decision should be made whether to abstain from breast-feeding or to discontinue Neparvis while breast-feeding, taking into account the importance of Neparvis to the mother.
Slovenian: Odločiti se je treba med prenehanjem dojenja ali prenehanjem zdravljenja z zdravilom Neparvis v času dojenja, pri čemer je treba pretehtati, kako pomembno je zdravilo Neparvis za mater.
English: You can take Neparvis with or without food.
Slovenian: Zdravilo Neparvis lahko jemljete skupaj s hrano ali brez nje.
English: Valsartan is minimally metabolised, as only about 20% of the dose is recovered as metabolites.
Slovenian: Valsartan se zelo malo presnavlja, saj je le 20 % odmerka mogoče prestreči v obliki presnovkov.
English: Stopping your treatment with Neparvis may cause your condition to get worse.
Slovenian: Če prekinete zdravljenje z zdravilom Neparvis, se vam lahko bolezen poslabša.
English: • if you are suffering from dehydration.
Slovenian: • če ste dehidrirani.
English: The concomitant use of Neparvis with ACE inhibitors is contraindicated, as the concomitant inhibition of neprilysin (NEP) and ACE may increase the risk of angioedema.
Slovenian: Sočasna uporaba zdravila Neparvis in zaviralcev ACE je kontraindicirana, saj sočasno zaviranje neprilizina (NEP) in ACE lahko poveča tveganje za angioedem.
English: • some types of antibiotics (rifamycin group), ciclosporin (used to prevent rejection of transplanted organs) or antivirals such as ritonavir (used to treat HIV/AIDS).
Slovenian: • nekaterih vrst antibiotikov (iz skupine rifamicinskih antibiotikov), ciklosporina (ki ga uporabljamo za preprečevanje zavrnitve presajenih organov) ali protivirusnih zdravil, kot je ritonavir (ki ga uporabljamo za zdravljenje okužbe z virusom HIV oziroma bolezni AIDS).
English: If the combination proves necessary, careful monitoring of serum lithium levels is recommended.
Slovenian: Če se pokaže, da je ju je treba uporabiti v kombinaciji, je priporočeno skrbno spremljanje koncentracije litija v serumu.
English: Caution is required in patients with renal artery stenosis and monitoring of renal function is recommended.
Slovenian: Pri bolnikih s stenozo ledvične arterije je potrebna previdnost, priporočeno pa je spremljanje delovanja ledvic.
English: What Neparvis is and what it is used for What you need to know before you take Neparvis How to take Neparvis
Slovenian: Kaj je zdravilo Neparvis in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Neparvis Kako jemati zdravilo Neparvis Možni neželeni učinki
English: Due to discontinuations during the run-in period, the adverse reaction rates as presented in table below may be lower than the adverse reaction rates expected in clinical practice.
Slovenian: Zaradi izstopov iz študije že v uvajalnem obdobju so spodaj navedene pogostnosti neželenih učinkov morda manjše od pogostnosti neželenih učinkov, ki bi jih pričakovali v klinični praksi.
English: The usual recommended target dose is 97 mg/103 mg twice a day (one tablet in the morning and one tablet in the evening).
Slovenian: Običajni priporočeni ciljni odmerek je 97 mg/103 mg dvakrat na dan (ena tableta zjutraj in ena tableta zvečer).
English: Where there is involvement of the tongue, glottis or larynx likely to cause airway obstruction, appropriate therapy, e.g. adrenaline solution 1 mg/1 ml (0.3-0.5 ml), and/or measures necessary to ensure a patent airway, should be promptly administered.
Slovenian: Kadar so zajeti jezik, glotis ali grlo, kar lahko povzroči zaporo dihalnih poti, je treba takoj začeti z ustreznim zdravljenjem, na primer z apliciranjem raztopine adrenalina 1 mg/1 ml (0,3-0,5 ml) in/ali z ukrepi za zagotavljanje prehodnosti dihalnih poti.
English: In vitro metabolism studies indicate that potential for CYP 450-based drug interactions is low since there is limited metabolism of Neparvis via CYP450 enzymes.
Slovenian: In vitro študije metabolizma kažejo, da je možnost za s CYP 450 povezane interakcije majhna, saj se zdravilo Neparvis le v majhni meri presnavlja z encimi CYP450.
English: Nitrates, e.g. nitroglycerine
Slovenian: Nitrati, na primer nitroglicerin
English: The average apparent volume of distribution of valsartan and sacubitril were 75 litres to 103 litres, respectively.
Slovenian: Povprečni navidezni volumen porazdelitve valsartana znaša 75 litrov, sakubitrila pa 103 litre.
English: This medicine is not for use in children (aged below 18 years).
Slovenian: To zdravilo ni namenjeno uporabi pri otrocih (starih manj kot 18 let), ker uporabe zdravila pri tej starostni skupini niso proučili.
English: There are no available data on the effect of Neparvis on human fertility.
Slovenian: O vplivu zdravila Neparvis na plodnost pri ljudeh ni na voljo nobenih podatkov.
English: • Hereditary or idiopathic angioedema (see section 4.4).
Slovenian: • Dedni ali idiopatski angioedem (glejte poglavje 4.4).
English: If any of the above applies to you, do not take Neparvis and talk to your doctor.
Slovenian: Če karkoli od navedenega velja za vas, ne jemljite zdravila Neparvis, ampak se pogovorite s svojim zdravnikom.
English: Very common Orthostatic hypotension Common
Slovenian: zelo pogosti ortostatska hipotenzija pogosti
English: Table 1 List of adverse reactions
Slovenian: Preglednica 1 Seznam neželenih učinkov
English: These kidney changes represent an expected exaggerated pharmacological effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 blockers; such effects are observed if rats are treated during the first 13 days of life.
Slovenian: Navedene spremembe v ledvicah predstavljajo pričakovano prekomerno farmakološko delovanje zaviralcev angiotenzinske konvertaze in zaviralcev receptorjev angiotenzina II tipa 1: tako delovanje opažajo pri podganah, če jim dajejo zdravilo v prvih 13 dneh življenja.
English: • if you are taking another type of medicine called an angiotensin converting enzyme (ACE) inhibitor (for example enalapril, lisinopril or ramipril).
Slovenian: • če jemljete drugo vrsto zdravil, ki jih imenujemo zaviralci angiotenzinske konvertaze (zaviralci ACE, na primer enalapril, lizinopril ali ramipril).
English: Sacubitril, LBQ657 and valsartan are eliminated from plasma with a mean elimination half-life (T½) of approximately 1.43 hours, 11.48 hours, and 9.90 hours, respectively.
Slovenian: Sakubitril, substanca LBQ657 in valsartan se izločajo iz plazme s povprečnimi razpolovnimi časi izločanja (T½) približno 1,43 ure, 11,48 ure oziroma 9,90 ure.
English: The medicinal product is unlikely to be removed by haemodialysis due to high protein binding.
Slovenian: Zdravila po vsej verjetnosti ni mogoče odstranjevati iz telesa s hemodializo, ker se v veliki meri veže na beljakovine.
English: The components of Neparvis, sacubitril and valsartan, were excreted in the milk of lactating rats (see section 5.3).
Slovenian: Sestavini zdravila Neparvis - sakubitril in valsartan - sta se izločali v mleko doječih podgan (glejte poglavje 5.3).
English: Co-administration of Neparvis with metformin reduced both Cmax and AUC of metformin by 23%.
Slovenian: Sočasna uporaba zdravila Neparvis in metformina je zmanjšala vrednosti tako Cmax kot AUC metformina za 23 %.
English: Sacubitril is further metabolised to the active metabolite LBQ657.
Slovenian: Sakubitril se naprej metabolizira v aktivni presnovek LBQ657.