FrancophonIA/ELRC3.0 huggingface dataset:
English: - You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
Slovenian: - Kljub jemanju tega zdravila lahko še vedno s HIV okužite druge osebe, čeprav je tveganje zmanjšano z učinkovitim protiretrovirusnim zdravljenjem.
English: This proportion is approximately 3-fold higher than the non-protein-bound (free) fraction of efavirenz in plasma.
Slovenian: Ta delež je približno 3-krat višji od frakcije efavirenza v plazmi, ki ni vezana na beljakovine (prosta frakcija).
English: - Medicines used to treat infection with the hepatitis C virus: boceprevir, telaprevir,
Slovenian: - Zdravila za zdravljenje okužbe z virusom hepatitisa C: boceprevir, telaprevir,
English: Patients should be advised that if they experience symptoms such as severe depression, psychosis or suicidal ideation, they should contact their doctor immediately to assess the possibility that the symptoms may be related to the use of efavirenz, and if so, to determine whether the risks of continued therapy outweigh the benefits (see section 4.8).
Slovenian: Bolnikom je treba svetovati, naj se v primeru pojava simptomov, kot so huda oblika depresije, psihoza ali misel na samomor, nemudoma posvetujejo z zdravnikom, ki bo ocenil, ali so simptomi lahko povezani z jemanjem efavirenza, in odločil, ali je tveganje nadaljevanja zdravljenja z efavirenzem večje od koristi (glejte poglavje 4.8).
English: Tell your doctor if you notice any of the following side effects: Very common (affects more than 1 user in 10)
Slovenian: Zdravniku povejte, če opazite katerega koli od naslednjih neželenih učinkov: Zelo pogosti (pojavijo se pri več kot 1 od 10 bolnikov) - kožni izpuščaj
English: No dose adjustment is necessary for rifampicin, including 600 mg.
Slovenian: Prilagoditev odmerka rifampicina, vključno s 600 mg, ni potrebna.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucosegalactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, odsotnostjo encima laktaze ali malabsorpcijo glukozegalaktoze ne smejo jemati tega zdravila.
English: Verapamil, felodipine, nifedipine and nicardipine
Slovenian: verapamil, felodipin, nifedipin in nikardipin
English: If you are pregnant, you should take Efavirenz Teva only if you and your doctor decide it is clearly needed.
Slovenian: Če ste noseči, lahko zdravilo Efavirenz Teva jemljete le, če se z zdravnikom skupaj odločita, da je to nujno potrebno.
English: Neither aluminium/magnesium hydroxide antacids nor famotidine altered the absorption of efavirenz.
Slovenian: Niti aluminijevi/ magnezijevi hidroksidni antacidi niti famotidin niso spremenili absorpcije efavirenza.
English: elbasvir/grazoprevir, simeprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, glecaprevir/pibrentasvir.
Slovenian: elbasvir/grazoprevir, simeprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voksilaprevir, glekaprevir/pibrentasvir.
English: These drugs include: - antiarrhythmics of classes IA and III, - neuroleptics, antidepressive agents,
Slovenian: Med taka zdravila sodijo: - antiaritmiki razreda IA in III, - nevroleptiki, antidepresivi,
English: In addition, your doctor may prescribe a higher dose of Efavirenz Teva.
Slovenian: Poleg tega vam bo zdravnik morda predpisal večji odmerek zdravila Efavirenz Teva.
English: Your doctor has prescribed Efavirenz Teva for you because you have HIV infection.
Slovenian: Zdravnik vam je predpisal zdravilo Efavirenz Teva, ker ste okuženi z virusom HIV.
English: Clarithromycin 14-hydroxymetabolite:
Slovenian: klaritromicin 14-hidroksimetabolit:
English: If you have taken Efavirenz Teva or the combination tablet containing efavirenz, emtricitabine, and tenofovir during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Slovenian: Če zdravilo Efavirenz Teva ali kombinirano zdravilo, ki vsebuje efavirenz, emtricitabin in tenofovir jemljete med nosečnostjo, bo zdravnik morda naročil redne krvne preiskave in druge diagnostične teste za spremljanje razvoja otroka.
English: - Immunosuppressants such as cyclosporine, sirolimus, or tacrolimus (medicines used to prevent organ transplant rejection): when you start or stop taking Efavirenz Teva, your doctor will closely monitor your plasma levels of the immunosuppressant and may need to adjust its dose.
Slovenian: - Imunosupresive, kot so ciklosporin, sirolimus ali takrolimus (zdravila za preprečitev zavrnitve presajenega organa): ko boste začeli ali prenehali jemati zdravilo Efavirenz Teva, bo zdravnik skrbno nadzoroval količino imunosupresiva v plazmi in bo morda moral prilagoditi njegov odmerek.
English: Efavirenz has a relatively long terminal half-life of at least 52 hours after single doses and 40-55 hours after multiple doses.
Slovenian: Efavirenz ima relativno dolg končni razpolovni čas: vsaj 52 ur po enkratnem odmerku in 40 do 55 ur po večkratnih odmerkih.
English: Five of these NNRTI-resistant isolates were found to have K103N or a valine-to-isoleucine substitution at position 108 (V108I) in RT. Three of the efavirenz treatment failure isolates tested remained sensitive to efavirenz in cell culture and were also sensitive to nevirapine and delavirdine.
Slovenian: Pri petih od teh na NNRTI rezistentnih izolatov so našli substitucijo K103N ali substitucijo valin-v-izolevcin na položaju 108 (V108I) na RT. Trije od teh testiranih izolatov iz neuspešnega zdravljenja z efavirenzem so ostali občutljivi na efavirenz v celični kulturi in so bili občutljivi tudi na nevirapin in delavirdin.
English: Since use of two NNRTIs proved not beneficial in terms of efficacy and safety, co-administration of efavirenz and another NNRTI is not recommended.
Slovenian: Ker uporaba dveh zdravil NNRTI ni pokazala koristi glede učinkovitosti in varnosti, sočasne uporabe efavirenza in drugega zdravila NNRTI ne priporočamo.
English: 30 x 1 film-coated tablets.
Slovenian: 30 x1 filmsko obložena tableta.
English: Study 020 showed similar activity in NRTI-experienced patients over 24 weeks.
Slovenian: Študija 020 je pri bolnikih, ki so se že zdravili z NRTI, po 24 tednih pokazala podobno aktivnost.
English: Efavirenz regimen Control regimen (n=1,008)
Slovenian: bolniki, ki so prejemali efavirenz kontrolna skupina (n = 1.008)
English: - Medicines used to lower blood fats (also called statins): atorvastatin, pravastatin, simvastatin.
Slovenian: - Zdravila za znižanje maščob v krvi (imenovana tudi statini): atorvastatin, pravastatin, simvastatin.
English: Sufficient data on the tolerability of efavirenz with low-dose ritonavir (100 mg, once or twice daily) are not available.
Slovenian: Zadostnih podatkov o prenašanju efavirenza z majhnimi odmerki ritonavirja (100 mg, enkrat ali dvakrat na dan) ni na voljo.
English: Taking these medicines with Efavirenz Teva could create the potential for serious and/or life-threatening side effects or stop Efavirenz Teva from working properly.
Slovenian: Jemanje teh zdravil skupaj z zdravilom Efavirenz Teva bi lahko povzročilo resne in/ali življenjsko nevarne neželene učinke ali preprečilo pravilno delovanje zdravila Efavirenz Teva.
English: The potency of efavirenz in cell culture against viral variants with amino acid substitutions at positions 48, 108, 179, 181 or 236 in RT or variants with amino acid substitutions in the protease was similar to that observed against wild-type viral strains.
Slovenian: Učinkovitost efavirenza v celičnih kulturah proti virusnim različicam z aminokislinskimi substitucijami na mestih 48, 108, 179, 181 ali 236 na RT ali različicam z aminokislinskimi substitucijami na proteazi je bila podobna njegovi učinkovitosti proti divjim tipom virusnih sevov.
English: Efavirenz: no clinically significant interaction.
Slovenian: efavirenz: Ni klinično pomembnih interakcij.
English: - Diltiazem or similar medicines (called calcium channel blockers which are medicines typically used for high blood pressure or heart problems): when you start taking Efavirenz
Slovenian: - Diltiazem ali podobna zdravila (imenovana zaviralci kalcijevih kanalčkov, zdravila, ki se običajno uporabljajo za zvišan krvni tlak ali težave s srcem): ko boste začeli jemati zdravilo
English: Mean Cmin µg/mL
Slovenian: Cmin µg/ml
English: ↓velpatasvir ↓voxilaprevir
Slovenian: ↓velpatasvir ↓voksilaprevir
English: Cross-resistance profiles for efavirenz, nevirapine and delavirdine in cell culture demonstrated that the K103N substitution confers loss of susceptibility to all three NNRTIs.
Slovenian: Profili navzkrižne rezistence na efavirenz, nevirapin in delavirdin v celičnih kulturah so pokazali, da substitucija K103N povzroči izgubo občutljivosti na vse tri NNRTI.
English: - Efavirenz Teva must be taken with other medicines that act against the HIV virus.
Slovenian: - Efavirenz Teva je treba jemati skupaj z drugimi zdravili, ki delujejo proti virusu HIV.
English: Efficacy results for studies ACTG 364 and 020 are found in Table 3.
Slovenian: Rezultate učinkovitosti v študijah ACTG 364 in 020 prikazuje preglednica 4.
English: The free concentration of efavirenz required for 90 to 95% inhibition of wild type or zidovudine-resistant laboratory and clinical isolates in vitro ranged from 0.46 to 6.8 nM in lymphoblastoid cell lines, peripheral blood mononuclear cells (PBMCs) and macrophage/monocyte cultures.
Slovenian: Koncentracija prostega efavirenza, potrebna za 90 % do 95 % in vitro inhibicijo laboratorijskih in kliničnih izolatov divjega tipa ali tistih, ki so rezistentni na zidovudin, je bila v območju od 0,46 do 6,8 nM, in sicer v limfoblastoidnih celičnih linijah, perifernih krvnih enojedrnih celicah (PBMC) in v kulturah makrofagov/monocitov.
English: Lipid disorders should be managed as clinically appropriate
Slovenian: Motnje lipidov je treba obravnavati klinično ustrezno.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se, preden začnete jemati to zdravilo, posvetujte z njim.
English: Tests may show: - increased cholesterol in the blood
Slovenian: Testi lahko pokažejo: - povišane vrednosti holesterola v krvi
English: Component of a multipack, can't be sold separately.
Slovenian: Pakiranje je del pakiranja z več enotami in se ne izdaja posamezno.
English: This medicine contains 9.98 mg lactose (as monohydrate) per tablet.
Slovenian: To zdravilo vsebuje 9,98 mg laktoze (v obliki monohidrata) na tableto.
English: Cetirizine:
Slovenian: cetirizin:
English: In HIV-1 infected patients (n=6), the pharmacokinetics of indinavir and efavirenz were generally comparable to these uninfected volunteer data.
Slovenian: Pri bolnikih, okuženih s HIV-1 (n = 6), sta bili farmakokinetiki indinavirja in efavirenza primerljivi s podatki za neokužene prostovoljce.
English: When prescribing medicinal products concomitantly with efavirenz, physicians should refer to the corresponding Summary of Product Characteristics.
Slovenian: Pri predpisovanju zdravil, ki se jemljejo hkrati z efavirenzem, mora zdravnik upoštevati ustrezni povzetek glavnih značilnosti zdravila.
English: If you take too much Efavirenz Teva, contact your doctor or nearest emergency department for advice.
Slovenian: Če vzamete preveč zdravila Efavirenz Teva, se posvetujte z zdravnikom ali z najbližjo urgenco.
English: The pharmacokinetic parameters for efavirenz at steady state in paediatric patients were predicted by a population pharmacokinetic model and are summarized in Table 4 by weight ranges that correspond to the recommended doses of the capsules.
Slovenian: Pediatrična populacija Farmakokinetični parametri efavirenza v stanju dinamičnega ravnovesja pri pediatričnih bolnikih so bili predvideni s populacijskim modelom farmakokinetike in so povzeti v preglednici 4, razvrščeni po telesni masi, ki ustreza priporočenim odmerkom kapsul.
English: Interactions between efavirenz and protease inhibitors, antiretroviral agents other than protease inhibitors and other non-antiretroviral medicinal products are listed in Table 1 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, and once every 8 or 12 hours as “q8h” or “q12h”).
Slovenian: Interakcije med efavirenzem in zaviralci proteaze, protiretrovirusnimi učinkovinami, ki niso zaviralci proteaze, in drugimi neprotiretrovirusnimi zdravili so navedene v preglednici 1 spodaj (povečanje je označeno z znakom “↑”, zmanjšanje z “↓”, brez spremembe z “↔”, ter enkrat na 8 ur oz. 12 ur z oznako “q8h” oz. “q12h”).
English: - Medicines that impact heart rhythm: Medicines used to treat heart rhythm problems: such as flecainide or metoprolol.
Slovenian: - Zdravila, ki vplivajo na srčni ritem: - zdravila za zdravljenje težav s srčnim ritmom: kot sta flekainid ali metoprolol.
English: This medicine contains less than 1 mmol sodium (23 mg) per tablet that is to say essentially ‘sodiumfree'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na tableto, kar v bistvu pomeni 'brez natrija'.
English: Efavirenz has been studied in over 9,000 patients.
Slovenian: Povzetek profila varnosti Efavirenz so preučevali pri več kot 9.000 bolnikih.
English: (hallucinations), mania (mental condition characterised by episodes of overactivity, elation or irritability), paranoia, suicidal thoughts, catatonia (condition in which the patient is rendered motionless and speechless for a period) - whistling, ringing or other persistent noise in the ears - tremor (shaking) - flushing
Slovenian: (duševno stanje, za katerega so značilna obdobja povečane aktivnosti, vznesenosti ali razdražljivosti), paranoja, misli na samomor, katatonija (stanje pri katerem bolnik v nekem obdobju ostane negiben in onemel) - piskanje, zvonjenje ali drugi nenehni zvoki v ušesih - tremor (tresenje) - zardevanje
English: - The dose for Efavirenz Teva may need to be increased or decreased if you are also taking certain medicines (see Other medicines and Efavirenz Teva).
Slovenian: - Odmerek zdravila Efavirenz Teva bo morda treba povečati ali zmanjšati v primeru, da jemljete še kakšna druga zdravila (glejte poglavje Druga zdravila in zdravilo Efavirenz Teva).
English: - If you have a heart condition, such as changes in the rhythm or rate of the heart beat, a slow heart beat, or severe heart disease.
Slovenian: - če imate hudo bolezen jeter - če imate bolezen srca, kot so sprememba ritma ali hitrosti bitja srca, počasen srčni utrip ali hudo bolezen srca.
English: What Efavirenz Teva is and what it is used for
Slovenian: Kaj je zdravilo Efavirenz Teva in za kaj ga uporabljamo
English: - severe depression - suicidal ideation - non-fatal suicide attempts - aggressive behaviour - paranoid reactions - manic reactions
Slovenian: - huda oblika depresije - misel na samomor - samomorilni poskusi (ne smrtni) 0,4 % - agresivno vedenje - paranoidne reakcije
English: Teva, your doctor may need to adjust your dose of the calcium channel blocker.
Slovenian: Efavirenz Teva, vam bo zdravnik morda moral prilagoditi odmerek zaviralca kalcijevih kanalčkov.
English: Patients should be instructed that if they experience these symptoms they should avoid potentially hazardous tasks such as driving or operating machinery.
Slovenian: naj se v primeru teh simptomov izogibajo potencialno nevarnim opravilom, kakršna sta vožnja ali upravljanje strojev.
English: A few of the postmarketing reports of hepatic failure, including cases in patients with no pre-existing hepatic disease or other identifiable risk factors, were characterized by a fulminant course, progressing in some cases to transplantation or death.
Slovenian: V nekaj postmarketinških poročilih o odpovedi jeter, vključno s primeri pri bolnikih brez predhodne bolezni jeter ali drugih odkritih dejavnikov tveganja, je bil opisan tudi fulminantni potek, ki je v nekaterih primerih napredoval do transplatacije ali smrti.
English: - Medicines used to treat bacterial infections including tuberculosis and AIDS-related mycobacterium avium complex: clarithromycin, rifabutin, rifampicin.
Slovenian: - Zdravila za zdravljenje bakterijskih okužb, vključno s tuberkulozo in z AIDS-om povezano okužbo z Mycobacterium avium: klaritromicin, rifabutin, rifampicin.
English: Efavirenz is a NNRTI of HIV-1.
Slovenian: Mehanizem delovanja Efavirenz je NNRTI HIV-1.
English: - a history of symptomatic cardiac arrhythmias or with clinically relevant bradycardia or with congestive cardiac failure accompanied by reduced left ventricle ejection fraction.
Slovenian: - anamnezo simptomatskih srčnih aritmij ali s klinično pomembno bradikardijo ali s kongestivnim srčnim popuščanjem skupaj z zmanjšanim iztisnim deležem levega prekata.
English: Table 1: Interactions between efavirenz and other medicinal products in adults
Slovenian: Interakcije med efavirenzem in drugimi zdravili pri odraslih
English: paranoia, psychosis†, suicide attempt, suicide ideation, catatonia*
Slovenian: halucinacije, manija, paranoja, psihoza†, poskus samomora, misli na samomor, katatonija*
English: It is recommended that efavirenz be taken on an empty stomach.
Slovenian: Priporočamo, da se efavirenz jemlje na prazen želodec.
English: Mean Cmax µg/mL
Slovenian: Cmax µg/ml
English: Efavirenz Teva with food and drink
Slovenian: Zdravilo Efavirenz Teva skupaj s hrano in pijačo
English: - certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones,
Slovenian: - določeni antibiotiki, vključno z učinkovinami iz naslednjih razredov: makrolidi, fluorokinoloni,
English: (CYP3A4 induction) Rash developed in 46% of uninfected volunteers receiving efavirenz and clarithromycin.
Slovenian: (indukcija CYP3A4) Pri 46 % neokuženih prostovoljcih se je med jemanjem efavirenza in klaritromicina pojavil izpuščaj.
English: If you notice any symptoms of infection, please tell your doctor immediately.
Slovenian: Če opazite kakršne koli znake okužbe, prosimo, da to takoj poveste zdravniku.
English: (UGT1A1 induction)
Slovenian: (indukcija UGT1A1)
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV in/ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART).
English: Each film-coated tablet contains 9.98 mg lactose (as monohydrate).
Slovenian: Ena filmsko obložena tableta vsebuje 9,98 mg laktoze (v obliki monohidrata).
English: If you have severe liver disease, do not take Efavirenz Teva (see section 2,
Slovenian: Če imate hudo bolezen jeter, ne jemljite zdravila Efavirenz Teva (glejte poglavje 2, NE jemljite zdravila Efavirenz Teva).
English: Taking Efavirenz Teva on an empty stomach may reduce the undesirable effects.
Slovenian: Jemanje zdravila Efavirenz Teva na tešče lahko zmanjša neželene učinke.
English: What Efavirenz Teva is and what it is used for What you need to know before you take Efavirenz Teva How to take Efavirenz Teva Possible side effects
Slovenian: Kaj je zdravilo Efavirenz Teva in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Efavirenz Teva Kako jemati zdravilo Efavirenz Teva Možni neželeni učinki
English: If efavirenz and telaprevir are coadministered, telaprevir 1,125 mg every 8 hours should be used.
Slovenian: Pri sočasni uporabi efavirenza in telaprevirja je treba uporabiti telaprevir v odmerku 1,125 mg vsakih 8 ur.
English: - Hormonal contraceptive, such as birth control pills, an injected contraceptive (for example, Depo-Provera), or a contraceptive implant (for example, Implanon): you must also use a reliable barrier method of contraception (see Pregnancy, breast-feeding and fertility).
Slovenian: - Hormonske kontraceptive, kot so kontracepcijske tablete, kontraceptivi v obliki injekcij (na primer Depo-Provera) ali kontracepcijski vsadki (na primer Implanon): uporabljati morate tudi zanesljivo mehansko obliko kontracepcije (glejte Nosečnost in dojenje).
English: The potential for cross-resistance between efavirenz and NRTIs is low because of the different binding sites on the target and mechanism of action.
Slovenian: Možnost za navzkrižno rezistenco med efavirenzem in NRTI je majhna zaradi različnih vezavnih mest in različnega mehanizma delovanja.
English: Efavirenz film-coated tablets are not suitable for children weighing less than 40 kg. Other formulations are available for these patients.
Slovenian: Zdravilo Efavirenz filmsko obložene tablete niso primerne za otroke, katerih telesna teža je manj kot 40 kg. Za te bolnike so na voljo druge formulacije.
English: Injection:
Slovenian: injekcija).
English: Efavirenz is not recommended for patients who have had a life-threatening cutaneous reaction (e.g., Stevens-Johnson syndrome) while taking another NNRTI.
Slovenian: Efavirenza ne priporočamo bolnikom, ki so imeli med jemanjem drugega NNRTI življenje ogrožajočo reakcijo na koži (npr. Stevens-Johnsonov sindrom).
English: (Inhibition of CYP-mediated oxidative metabolism) When efavirenz was given with ritonavir 500 mg or 600 mg twice daily, the combination was not well tolerated (for example, dizziness, nausea, paraesthesia and elevated liver enzymes occurred).
Slovenian: (zaviranje oksidativne presnove, pri kateri sodelujejo encimi CYP) Kadar so efavirenz dajali skupaj s 500 mg ali 600 mg ritonavirja dvakrat na dan, bolniki te kombinacije niso dobro prenašali (pojavili so se na primer omotica, navzea, parestezija in zvišane vrednosti jetrnih encimov).
English: In a subset of 1,008 adult patients who received 600 mg efavirenz daily in combination with PIs and/or NRTIs in controlled clinical studies, the most frequently reported adverse reactions of at least moderate severity reported in at least 5% of patients were rash (11.6%), dizziness (8.5%), nausea (8.0%), headache (5.7%) and fatigue (5.5%).
Slovenian: V podskupini 1.008 odraslih bolnikov, ki so v nadzorovanih kliničnih študijah prejemali dnevno 600 mg efavirenza v kombinaciji z ZP-ji in/ali NRTI-ji, so bili najpogostejši neželeni učinki, ki so bili vsaj zmerne jakosti in so o njih poročali pri vsaj 5 % bolnikov: izpuščaj (11,6 %), omotica (8,5 %), navzea (8,0 %), glavobol (5,7 %) in utrujenost
English: Efavirenz may be an inducer of CYP2C19 and CYP2C9; however inhibition has also been observed in vitro and the net effect of co-administration with substrates of these enzymes is not clear (see section 5.2).
Slovenian: Efavirenz morda inducira CYP2C19 in CYP2C9, vendar so opazili tudi inhibicijo in vitro, in zato skupni učinek sočasne uporabe s substrati za ta encima ni jasen (glejte poglavje 5.2).
English: 30 film-coated tablets 30 x 1 film-coated-tablets 90 x 1 film-coated tablets 90 film-coated tablets
Slovenian: 30 filmsko obloženih tablet 30 x 1 filmsko obložena tableta 90 x 1 filmsko obložena tableta 90 filmsko obloženih tablet
English: Two of three delavirdine-resistant clinical isolates examined were cross-resistant to efavirenz and contained the K103N substitution.
Slovenian: Dva od treh kliničnih izolatov, rezistentnih na delavirdin, ki so jih preučevali, sta bila navzkrižno rezistentna na efavirenz in sta vsebovala substitucijo K103N.
English: Evening Cmax: ↔
Slovenian: Cmax zvečer: ↔
English: Frequency is defined using the following convention: very common (≥ 1/10); common (≥ 1/100 to
Slovenian: Pogostnost je definirana z uporabo sledečega dogovora: zelo pogosti (≥ 1/10); pogosti (≥ 1/100, < 1/10); občasni (≥ 1/1.000, < 1/100); redki (≥ 1/10.000, < 1/1.000)
English: Exposures of raltegravir (a UGT1A1 substrate) are reduced in the presence of efavirenz (see section 4.5, table 1).
Slovenian: Izpostavitev raltegravirju (substratu za UGT1A1) se v prisotnosti efavirenza zmanjša (glejte poglavje 4.5, Preglednica 1).