FrancophonIA/ELRC3.0 huggingface dataset:
English: The absolute bioavailability of subcutaneously administered canakinumab was estimated to be 66%.
Croatian: Apsolutna bioraspoloživost supkutano primjenjenog kanakinumaba procjenjivala se na 66%.
English: Inflammatory markers* C-reactive protein, mg/l Serum amyloid A, mg/l * mean (median) change from beginning of Part II
Croatian: Upalni markeri* C-reativni protein, mg/l Serumski amiloid A, mg/l * srednja (medijan) promjena od početka II. dijela
English: After proper training in the correct injection technique, patients or their caregivers may inject Ilaris if the physician determines that it is appropriate and with medical follow-up as necessary (see section 6.6).
Croatian: Nakon odgovarajuće obuke iz pravilne tehnike davanja injekcije bolesnici ili njihovi njegovatelji mogu ubrizgati Ilaris ako njihov liječnik smatra da je to primjereno te uz odgovarajuću medicinsku kontrolu prema potrebi (vidjeti dio 6.6).
English: Of the patients treated with 600 mg or 8 mg/kg (or even higher), 43.8% achieved complete response.
Croatian: Od bolesnika liječenih dozom od 600 mg ili 8 mg/kg (ili čak i većom), 43,8% postiglo je potpun odgovor.
English: The distribution volume (Vss) of canakinumab varied according to body weight.
Croatian: Volumen distribucije (Vss) kanakinumaba bio je različit ovisno o tjelesnoj težini.
English: There is no significant difference in safety profile observed in patients ≥ 65 years of age.
Croatian: Nema značajne razlike u sigurnosnom profilu uočenom kod bolesnika u dobi od ≥65 godina.
English: For chronic or repeated therapies, it is also recommended to assess WBC counts periodically during treatment.
Croatian: Za kroničnu ili ponovljene terapije također se preporučuje utvrditi broj Lkc periodički tijekom liječenja.
English: - It is important not to try to inject yourself until you have been trained by your healthcare professional.
Croatian: Važno je da ne pokušavate sami sebi dati injekciju dok Vas zdravstveni djelatnik nije tome podučio.
English: The Marketing Authorisation Holder (MAH) shall ensure that, prior to launch, all physicians who are expected to prescribe/use Ilaris are provided with a physician information pack containing the following:
Croatian: Nositelj odobrenja dužan je osigurati da prije stavljanja lijeka na tržište svi liječnici za koje se očekuje da će propisivati/primjenjivati Ilaris dobiju informativni paket za liječnike koji će sadržavati sljedeće:
English: Injection into scar tissue should be avoided as this may result in insufficient exposure to canakinumab.
Croatian: Injiciranje u ožiljkasto tkivo treba izbjegavati budući da bi to moglo rezultirati nedostatnom izloženošću kanakinumabu.
English: After removing the vial from the refrigerator, check the expiry date on the vial.
Croatian: Nakon što izvadite bočicu iz hladnjaka, provjerite rok valjanosti na bočici.
English: If you experience a new attack, your doctor may consider giving you a new dose of Ilaris but not earlier than 12 weeks from the previous dose.
Croatian: Ako doživite novi napad, Vaš liječnik može razmotriti primjenu nove doze Ilarisa, ali ne prije nego što protekne 12 tjedana od prethodne doze.
English: However, the risk of severe hypersensitivity reactions, which is not uncommon for injectable proteins, cannot be excluded (see section 4.3).
Croatian: Međutim, rizik od teških reakcija preosjetljivosti, koji nije neubičajen kod proteina koji se ubrizgavaju, ne može se isključiti (vidjeti dio 4.3).
English: Avoid injecting into a vein.
Croatian: Izbjegavajte ubrizgavanje u venu.
English: Over 85% of patients had comorbidity, including hypertension (60%), diabetes (15%), ischaemic heart disease (12%), and stage ≥ 3 chronic kidney disease (25%).
Croatian: Više od 85% bolesnika imalo je komorbiditete koji su uključivali hipertenziju (60%), šećernu bolest (15%), ishemijsku bolest srca (12%) i kroničnu bolest bubrega stadija ≥3 (25%).
English: CAPS in adults and children  4 years of age  15 kg
Croatian: CAPS u odraslih i djece 4 godine 15 kg
English: They should not be used with Ilaris because this may increase the risk of infections.
Croatian: Ne smiju se primjenjivati s Ilarisom zato što bi to moglo povećati rizik od infekcija.
English: - After mixing (reconstitution) the medicine should be used immediately.
Croatian: Nakon miješanja (rekonstitucije) lijeka, potrebno ga je odmah upotrijebiti.
English: The majority of paediatric patients achieved improvement in clinical symptoms and objective markers of inflammation (e.g. SAA and CRP).
Croatian: Većina pedijatrijskih bolesnika postigla je poboljšanje kliničkih simptoma i objektivnih markera upale (npr. SAA i CRP).
English: Tuberculosis screening
Croatian: Probir tuberkuloze
English: No differences in safety or efficacy were observed in patients under the age of 2 years compared with patients aged 2 years and above.
Croatian: Nisu bile uočene razlike u sigurnosti ili djelotvornosti u bolesnika mlađih od 2 godine u usporedbi s bolesnicima u dobi od 2 i više godina.
English: Never re-use syringes or needles.
Croatian: Nikada nemojte ponovno upotrebljavati štrcaljke ili igle.
English: The doctor or nurse will demonstrate how to administer Ilaris injections.
Croatian: Liječnik ili medicinska sestra pokazat će kako se primjenjuju injekcije Ilarisa.
English: What Ilaris is and what it is used for What you need to know before you use Ilaris How to use Ilaris
Croatian: Što je Ilaris i za što se koristi Što morate znati prije nego počnete primjenjivati Ilaris Kako primjenjivati Ilaris
English: Mutation in NLRP3 gene in CAPS patients
Croatian: Mutacija u genu NLRP3 kod bolesnika s CAPS-om
English: Although limited, evidence from the clinical trials suggests that patients not responding to tocilizumab or anakinra may respond to canakinumab.
Croatian: Iako ograničeni, dokazi iz kliničkih ispitivanja upućuju na to da bi bolesnici koji nemaju odgovor na tocilizumab ili anakinru mogli imati odgovor na kanakinumab.
English: Accordingly, Tmax was shorter (3.6 days) in younger SJIA patients (2-3 years) compared to older SJIA patients (12-19 years; Tmax 6 days).
Croatian: Sukladno tome, Tmax bio je kraći (3,6 dana) u mlađih bolesnika sa SJIA-om (2-3 godine) u usporedbi sa starijim bolesnicima sa SJIA-om (12-19 godina; Tmax 6 dana).
English: If the solution has a distinctly brown discolouration it should not be used.
Croatian: Ako je otopina izrazito smeđe boje ne smije se koristiti.
English: Canakinumab is associated with an increased incidence of serious infections.
Croatian: Kanakinumab je povezan s povećanom incidencijom ozbiljnih infekcija.
English: The study included 243 CAPS patients (including 85 patients less than 18 years of age).
Croatian: Ispitivanje je uključivalo 243 bolesnika s CAPS-om (uključujući 85 bolesnika mlađih od 18 godina).
English: The European Medicines Agency has waived the obligation to submit the results of studies with Ilaris in all subsets of the paediatric population in gouty arthritis (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja Ilarisa u svim podskupinama pedijatrijske populacije s uričnim artritisom (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: A total of 185 patients aged 28 days and above were enrolled and a total of 181 patients aged 2 years and above were randomised in part II of the study.
Croatian: Ukupno je 185 bolesnika u dobi od 28 dana i starijih bilo uključeno, a ukupno je 181 bolesnik u dobi od 2 i više godina bio randomiziran u II. dio ispitivanja.
English: Fifty-seven (62%) of the 92 patients who attempted to taper were able to successfully taper their corticosteroid dose and 42 (46%) discontinued corticosteroids.
Croatian: Pedeset sedam (62%) od 92 bolesnika koji su pokušali smanjiti dozu uspješno je smanjilo svoju dozu kortikosteroida, a 42 (46%) prestalo je uzimati kortikosteroide.
English: Appropriate screening tests (e.g. tuberculin skin test, interferon gamma release assay or chest X-ray) should be performed in all patients (local recommendations may apply).
Croatian: Odgovarajuće testove probira (npr. tuberkulinski kožni test, test otpuštanja interferona gama ili rendgenska snimka pluća) valja provesti u svih bolesnika (mogu se primijeniti lokalne preporuke).
English: Clinical experience with dosing at intervals of less than 4 weeks or at doses above 600 mg or 8 mg/kg is limited.
Croatian: Klinička iskustva s doziranjem u intervalima kraćima od 4 tjedna ili pri dozama iznad 600 mg ili 8 mg/kg su ograničena.
English: From a microbiological point of view, the product should be used immediately after first opening.
Croatian: S mikrobiološkog stajališta, lijek se mora upotrijebiti odmah nakon prvog otvaranja.
English: • Muckle-Wells syndrome (MWS),
Croatian: • Muckle-Wellsov sindrom (MWS),
English: * Denotes significant p-value ≤ 0.025
Croatian: * Označava značajnu p-vrijednost <0,025
English: The study consisted of two parts with two independent primary endpoints (successful steroid taper and time to flare).
Croatian: Ispitivanje se sastojalo od dva dijela s dvije neovisne primarne mjere ishoda (uspješno smanjivanje doze steroida i vrijeme do naglog pogoršanja bolesti).
English: * human monoclonal antibody produced in mouse myeloma Sp2/0 cells by recombinant DNA technology
Croatian: * humano monoklonsko protutijelo proizvedeno u stanicama mišjeg mijeloma Sp2/0 tehnologijom rekombinantne DNA
English: Before initiation of therapy, all patients must be evaluated for both active and latent tuberculosis infection.
Croatian: Prije početka terapije potrebno je kod svih bolesnika odrediti postoji li aktivna ili latentna infekcija tuberkulozom.
English: Canakinumab also demonstrated superior efficacy compared to placebo on the secondary endpoints of PGA < 2 and CRP ≤ 10 mg/l in all three cohorts.
Croatian: Kanakinumab je ujedno pokazao i superiornu djelotvornost u odnosu na placebo za sekundarne mjere ishoda PGA <2 i CRP ≤10 mg/l u sve tri kohorte.
English: Periodic fever syndromes
Croatian: Sindromi periodičnih vrućica
English: 9/l) and leukopenia have been observed with medicinal products that inhibit IL-1, including canakinumab.
Croatian: 9/l) i leukopenija su bile zabilježene kod primjene lijekova koji inhibiraju IL-1, što uključuje i kanakinumab.
English: This is consistent with the observations of higher exposure in higher body weight groups in CAPS patients.
Croatian: To je ujednačeno s opažanjima više izloženosti u skupinama s većom tjelesnom težinom u bolesnika s CAPS-om.
English: It is recommended to select a different injection site each time the product is injected to avoid soreness.
Croatian: Preporučuje se odabrati drugo mjesto primjene za svaku injekciju lijeka kako bi se izbjegla bolnost.
English: Based on clinical trial experience, canakinumab does not appear to increase the incidence of MAS in SJIA patients, but no definitive conclusion can be made.
Croatian: Na temelju iskustava iz kliničkih ispitivanja, čini se da kanakinumab ne povećava incidenciju MAS-a u bolesnika sa SJIA-om, ali ne mogu se donijeti konačni zaključci.
English: Animal studies indicate that canakinumab crosses the placenta and is detectable in the foetus.
Croatian: Ispitivanja na životinjama pokazuju da kanakinumab prolazi placentu i može se otkriti u fetusu.
English: Formal studies of the potential effect of canakinumab on human fertility have not been conducted.
Croatian: Formalna ispitivanja potencijalnog učinka kanakinumaba na ljudsku plodnost nisu provedena.
English: Stopping your treatment with Ilaris may cause your condition to get worse.
Croatian: Prestanak liječenja Ilarisom može uzrokovati pogoršanje Vašeg stanja.
English: Only patients with confirmed NLRP3 mutation were included in the pivotal study.
Croatian: Samo su bolesnici s potvrđenim NLRP3 mutacijama bili uključeni u ključno ispitivanje.
English: Data from the first 12 weeks of canakinumab treatment from studies G2305, G2301 and the extension study were pooled to assess maintenance of efficacy.
Croatian: Podaci o prvih 12 tjedana liječenja kanakinumabom iz ispitivanja G2305, G2301 i produžetka ispitivanja bili su objedinjeni da bi se ocijenilo održavanje djelotvornosti.
English: Single use.
Croatian: Za jednokratnu primjenu.
English: All patients who received non-live, standard of care childhood vaccinations (N=7) developed protective antibody levels.
Croatian: U svih su se bolesnika koji su primili neživa, standardna dječja cjepiva (N=7) razvile zaštitne razine protutijela.
English: Although approximately 22% of patients receiving canakinumab required dose adjustment, only a small percentage of patients (1.2%) discontinued canakinumab due to lack of therapeutic effect.
Croatian: Iako je oko 22% bolesnika koji su primali kanakinumab trebalo prilagođavanje doze, samo je mali postotak bolesnika (1,2%) prestao uzimati kanakinumab zbog izostanka terapijskog učinka.
English: Abnormal levels of triglycerides in your blood (lipid metabolism disorder).
Croatian: Poremećene razine triglicerida u Vašoj krvi (poremećaj metabolizma lipida).
English: A total of 324 SJIA patients aged 2 to < 20 years have received Ilaris in interventional clinical trials, including 293 patients aged 2 to < 16 years old, 21 patients aged 16 to < 18 years old and 10 patients aged 18 to < 20 years old.
Croatian: Ukupno su 324 bolesnika sa SJIA-om u dobi od 2 do < 20 godina primala Ilaris u intervencijskim kliničkim ispitivanjima, uključujući 293 bolesnika u dobi od 2 do < 16 godina, 21 bolesnika u dobi od 16 do < 18 godina i 10 bolesnika u dobi od 18 do < 20 godina.
English: Should vaccination with live vaccines be indicated after initiation of canakinumab treatment, the recommendation is to wait for at least 3 months after the last canakinumab injection and before the next one (see section 4.4).
Croatian: Ako je cijepljenje živim cjepivima indicirano nakon početka liječenja kanakinumabom, preporuka je da se čeka najmanje 3 mjeseca nakon posljednje injekcije kanakinumaba i prije sljedeće (vidjeti dio 4.4).
English: In patients with periodic fever syndromes (CAPS, TRAPS, HIDS/MKD and FMF), the body produces too much IL-1 beta.
Croatian: Kod bolesnika sa sindromima periodičnih vrućica (CAPS-om, TRAPS-om, HIDS/MKD-om i FMFom), tijelo proizvodi previše IL-1 beta.
English: The patient or caregiver and the doctor should decide together who will administer the Ilaris injections.
Croatian: Bolesnik ili njegovatelj i liječnik moraju zajedno odlučiti tko će primijeniti injekcije Ilarisa.
English: Isolated cases of ANC counts < 0.5 x 10
Croatian: Izolirani slučajevi broja ABN <0,5 x 10
English: If you need to be given a live vaccine after starting treatment with Ilaris, discuss this with your doctor.
Croatian: Ako Vam je potrebno živo cjepivo nakon što započnete liječenje Ilarisom,,obratite se liječniku za savjet.
English: This is consistent with the observed increase in CL/F with body weight.
Croatian: To je u skladu s povećanjem CL/F uočenim s povećanjem tjelesne težine.
English: No apparent correlation of antibody development to clinical response or adverse events was observed.
Croatian: Nije bila uočena nikakva prividna veza između razvoja protutijela i kliničkog odgovora ili štetnih događaja.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C - 8°C.
Croatian: Ako se ne upotrijebi odmah, vrijeme i uvjeti čuvanja prije primjene odgovornost su korisnika i ne bi smjeli biti dulji od 24 sata na temperaturi od 2°C - 8°C.
English: Ilaris is available in packs containing one vial or multipacks comprising four intermediate packs, each containing one vial.
Croatian: Ilaris je dostupan u pakiranjima koja sadrže jednu bočicu ili u višestrukim pakiranjima koja sadrže četiri srednja pakiranja, od koji svako sadrži jednu bočicu.
English: At week 12, the adapted paediatric ACR30, 50, 70, 90 and 100 responses were: 70%, 69%, 61%, 49% and 30%, respectively and 28% of patients had inactive disease (N=178).
Croatian: Nakon 12 tjedana, prilagođeni pedijatrijski odgovori ACR30, 50, 70, 90 i 100 bili su: 70%, 69%, 61%, 49% odnosno 30%, a 28% bolesnika imalo je neaktivnu bolest (N=178).
English: The study also evaluated the effect of canakinumab on the development of antibodies to standard childhood vaccines.
Croatian: U ispitivanju se ocjenjivao i učinak kanakinumaba na razvoj protutijela na standardna dječja cjepiva.
English: You are advised to avoid being vaccinated with a type of vaccine called a live vaccine while being treated with Ilaris (see also “Other medicines and Ilaris”).
Croatian: Preporučuje se da izbjegavate cijepljenje vrstom cjepiva koje se naziva živim cjepivom dok se liječite Ilarisom (pogledajte također „Drugi lijekovi i Ilaris“).
English: The efficacy of canakinumab for the treatment of active SJIA was assessed in two pivotal studies (G2305 and G2301).
Croatian: Djelotvornost kanakinumaba u liječenju aktivne SJIA-e ocijenjena je u dva ključna ispitivanja (G2305 i G2301).
English: Drop in level of white blood cells which help prevent infection (neutropenia).
Croatian: Smanjenje razine bijelih krvnih stanica koje pomažu spriječiti infekciju (neutropenija).
English: You are advised to avoid becoming pregnant and must use adequate contraception while using Ilaris and for at least 3 months after the last Ilaris treatment.
Croatian: Preporučuje se da izbjegavate trudnoću i obvezno koristite odgovarajuću kontracepciju dok primjenjujete Ilaris te najmanje 3 mjeseca nakon posljednje terapije Ilarisom.
English: Without touching the rubber stopper, swirl (do not shake) the vial slowly at an angle of about 45 degrees for about 1 minute.
Croatian: Ne dodirujući gumeni čep polako vrtite (nemojte tresti) bočicu pod kutom od oko 45 stupnjeva otprilike 1 minutu.
English: Your doctor may check whether you have tuberculosis using a specific test. if you have signs of a liver disorder such as yellow skin and eyes, nausea, loss of appetite, darkcoloured urine and light-coloured stools.
Croatian: Vaš liječnik može provjeriti imate li tuberkulozu korištenjem specifičnog testa. ako imate znakove poremećaja jetre kao što su žutilo kože i očiju, mučnina, gubitak apetita, zatamnjena mokraća ili svjetla stolica.
English: Broken skin and areas which are bruised or covered by a rash should be avoided.
Croatian: Ozlijeđenu kožu i područja s modricama ili područja pokrivena osipom potrebno je izbjegavati.
English: Find a clean place in which to prepare and give yourself the injection.
Croatian: Pronađite čisto mjesto na kojem ćete pripremiti i dati si injekciju.
English: Patients who do not respond to initial treatment should not be re-treated with canakinumab.
Croatian: Bolesnici koji ne odgovore na početno liječenje ne smiju se ponovno liječiti kanakinumabom.
English: Your doctor will discuss with you the potential risks of taking Ilaris during pregnancy.
Croatian: Vaš liječnik će razgovarati s Vama o mogućim rizicima primjene Ilarisa tijekom trudnoće.
English: Release the pinched skin and pull the needle straight out.
Croatian: Otpustite uštipnutu kožu i izvucite iglu ravno prema gore.
English: Safety results showed an increased incidence of adverse events for canakinumab compared to triamcinolone acetonide, with 66% vs 53% of patients reporting any adverse event and 20% vs 10% of patients reporting an infection adverse event over 24 weeks.
Croatian: Rezultati sigurnosti pokazali su povećanu incidenciju štetnih događaja za kanakinumab u usporedbi s triamcinolon acetonidom, pri čemu je 66% u odnosu na 53% bolesnika prijavilo bilo koji štetni događaj te 20% u odnosu na 10% bolesnika prijavilo štetni događaj infekcije tijekom 24 tjedna.
English: A new flare was defined as a PGA score ≥ 2 (“mild, moderate, or severe disease”) and CRP ≥ 30 mg/l.
Croatian: Novo razbuktavanje bilo je definirano kao PGA ≥2 („blaga, umjerena ili teška bolest“) i CRP ≥30 mg/l.
English: Patients who maintained inactive disease status for 6 additional months at this lowest dose regimen were allowed to discontinue canakinumab.
Croatian: Bolesnici koji su održali status neaktivne bolesti dodatnih 6 mjeseci u ovom najmanjem režimu doziranja smjeli su prekinuti liječenje kanakinumabom.
English: Table 5 Efficacy for the overall study population and in a subgroup of patients currently using ULT and unable to use both NSAIDs and colchicine
Croatian: Tablica 5 Djelotvornost za cjelokupnu ispitivanu populaciju i u podskupini bolesnika koji trenutačno koriste ULT i koji ne mogu koristiti ni NSAIL-ove niti kolhicin
English: - Part I: Patients in each disease cohort aged 2 years and older entered a 12-week screening period during which they were evaluated for the onset of disease flare.
Croatian: - I. dio: bolesnici u svakoj kohorti prema bolesti u dobi od 2 i više godina ušli su u 12-tjedno razdoblje probira tijekom kojeg se kod njih ocjenjivao nastup razbuktavanja bolesti.
English: SJIA in young adults and AOSD
Croatian: SJIA u mladih osoba i SBOD
English: Neutropenia (absolute neutrophil count [ANC] < 1.5 x 10
Croatian: Neutropenija (apsolutni broj neutrofila [ABN] <1,5 x 10
English: Non-clinical data reveal no special hazard for humans based on conventional studies of crossreactivity, repeated dose toxicity, immunotoxicity, toxicity to reproduction and development.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja križne reaktivnosti, toksičnosti ponovljenih doza, imunotoksičnosti, ispitivanja toksičnosti za reprodukciju i razvoj.
English: Physicians should be attentive to symptoms of infection or worsening of Still's disease, as these are known triggers for MAS.
Croatian: Liječnici moraju obratiti pozornost na simptome infekcije ili pogoršanja Stillove bolesti, budući da su to poznati okidači za MAS.
English: Exposure parameters (such as AUC and Cmax) increased in proportion to dose over the dose range of 0.30 to 10.0 mg/kg given as intravenous infusion or from 150 to 600 mg as subcutaneous injection.
Croatian: Parametri izloženosti (kao što su AUC i Cmax) povećali su se proporcionalno dozi u rasponu doze od 0,30 do 10,0 mg/kg primijenjenih kao intravenska infuzija ili od 150 do 600 mg kao supkutana injekcija.
English: It is recommended that white blood cell (WBC) counts including neutrophil counts be assessed prior to initiating treatment and again after 1 to 2 months.
Croatian: Preporučuje se utvrditi broj leukocita (Lkc) uključujući broj neutrofila prije početka liječenja te ponovno nakon 1 do 2 mjeseca.
English: Drop in level of white blood cells (leukopenia).
Croatian: Smanjenje razine bijelih krvnih stanica (leukopenija).
English: Do not use an area that has a rash or broken skin, or is bruised or lumpy.
Croatian: Nemojte koristiti područje na kojem je osip ili ozlijeđena koža, ili koje ima modrice ili kvržice.
English: Prior to initiation of canakinumab therapy it is recommended that adult and paediatric patients receive all vaccinations, as appropriate, including pneumococcal vaccine and inactivated influenza vaccine (see section 4.5).
Croatian: Prije započinjanja terapije kanakinumabom, preporučuje se da odrasli i pedijatrijski bolesnici prime sva cjepiva, prema potrebi, uključujući pneumokokno cjepivo i inaktivirano cjepivo protiv gripe (vidjeti dio 4.5).
English: Centre de Biotechnologie 8, rue de l'Industrie 68330 Huningue France
Croatian: Novartis Pharma S.A.S. Centre de Biotechnologie 8, rue de l'Industrie 68330 Huningue Francuska
English: The results of a study in healthy adult subjects demonstrated that a single dose of Ilaris 300 mg did not affect the induction and persistence of antibody responses after vaccination with influenza or glycosylated protein based meningococcus vaccines.
Croatian: Rezultati ispitivanja u zdravih odraslih ispitanika pokazali su da jednokratna doza Ilarisa 300 mg nije utjecala na indukciju i perzistenciju odgovora protutijela nakon cijepljenja s cjepivima protiv gripe ili meningokoknog cjepiva temeljenog na glikoziliranom proteinu.