FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients taking Tafinlar may commonly (may affect up to 1 in 10 people) develop a different type of skin cancer called cutaneous squamous cell carcinoma (cuSCC).
Slovenian: Pri bolnikih, ki jemljejo zdravilo Tafinlar, se pogosto (pri največ 1 od 10 ljudi) lahko pojavi drugačna vrsta kožnega raka, ki ga imenujemo ploščatocelični karcinom kože (cuSCC - Cutaneous Squamous Cell Carcinoma).
English: These melanomas are usually removed by surgery and treatment with Tafinlar can be continued without interruption.
Slovenian: Te melanome po navadi odstranijo z operacijo in zdravljenje z zdravilom Tafinlar je mogoče nadaljevati brez prekinitve.
English: Patients should be routinely monitored for visual signs and symptoms (such as change in vision, photophobia and eye pain) while on therapy.
Slovenian: Bolnike je treba med zdravljenjem redno kontrolirati glede znakov in simptomov s strani vida (npr. sprememb vida, fotofobije in bolečin v očesu).
English: The study included patients with all sub-stages of Stage III disease prior to resection; 18% of these patients had lymph node involvement only identifiable by microscope and no primary tumour ulceration.
Slovenian: V študijo so bili vključeni bolniki, ki so imeli pred resekcijo melanom vseh podstadijev stadija III; pri 18 % teh bolnikov so bile zajete bezgavke odkrite samo pri mikroskopskem pregledu, niso pa imeli ulceracije primarnega tumorja.
English: earlier in section 4)
Slovenian: 4. poglavju)
English: • some medicines used to treat certain psychiatric conditions, such as haloperidol
Slovenian: • nekatera zdravila za zdravljenje določenih psihiatričnih motenj, npr. haloperidol
English: Data as of June 25, 2012
Slovenian: Podatki z dne 25. junija 2012
English: Enrollment required complete resection of melanoma with complete lymphadenectomy within 12 weeks prior to randomisation.
Slovenian: Pogoj za vključitev v študijo je bila totalna resekcija melanoma s popolno limfadenektomijo v zadnjih 12 tednih pred randomizacijo.
English: These changes in dabrafenib AUC and Cmax are considered not clinically meaningful.
Slovenian: Te spremembe AUC in Cmax dabrafeniba ne veljajo za klinično pomembne.
English: • If you do become pregnant while you are taking this medicine, tell your doctor immediately.
Slovenian: • Če med jemanjem tega zdravila zanosite, morate nemudoma obvestiti zdravnika.
English: • coloured dots in your vision
Slovenian: • obarvane pike v vašem vidu
English: Do not take a double dose to make up for a missed dose.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: Results were also consistent across stratification factors for disease stage and BRAF V600 mutation type.
Slovenian: Rezultati so se ujemali tudi po skupinah glede na stratifikacijske dejavnike stadija bolezni in vrste mutacije BRAF V600.
English: b This study was designed to support or reject the null hypothesis of OIRR ≤10% (based on historical results) in favour of the alternative hypothesis of OIRR ≥ 30% in BRAF V600E mutation positive subjects.
Slovenian: b Namen študije je bil podpreti ali zavrniti ničelno hipotezo o OIRR ≤ 10 % (na podlagi preteklih rezultatov) v korist alternativne hipoteze o OIRR ≥ 30 % med preiskovanci z mutacijo BRAF
English: Elderly No adjustment of the initial dose is required in patients >65 years of age.
Slovenian: Starejši bolniki Bolnikom, starejšim od 65 let, začetnega odmerka ni treba prilagoditi.
English: The increased Cmax of rosuvastatin is unlikely to have clinical relevance.
Slovenian: Povečanje vrednosti Cmax rosuvastatina verjetno ni klinično pomembno.
English: These checks are to detect if any other cancer, including squamous cell carcinoma, develops inside your body.
Slovenian: Namen teh preiskav je ugotoviti, ali se vam je v telesu pojavil kakšen drug rak, vključno s ploščatoceličnim karcinomom.
English: Dabrafenib is a substrate of human P-glycoprotein (Pgp) and human BCRP in vitro.
Slovenian: Dabrafenib je substrat humanega P-glikoproteina (Pgp) in humanega BCRP in vitro.
English: Compared with younger subjects (<65), more subjects 65 years old had adverse reactions that led to study drug dose reductions (22% versus 12%) or interruptions (39% versus 27%).
Slovenian: V primerjavi z mlajšimi bolniki (< 65 let) je imelo več bolnikov, starih  65 let, takšne neželene učinke, ki so povzročili znižanje odmerka preskušanega zdravila (22 % v primerjavi z 12 %) ali prekinitev zdravljenja (39 % v primerjavi s 27 %).
English: Once the fever is controlled, your doctor may recommend that you start taking Tafinlar again.
Slovenian: Ko je zvišana telesna temperatura obvladana, lahko zdravnik naroči, da znova začnete jemati zdravilo Tafinlar.
English: The assay was designed to detect the BRAF V600E and V600K mutations with high sensitivity (down to 5% V600E and V600K sequence in a background of wild-type sequence using DNA extracted from FFPE tissue).
Slovenian: Test je bil zasnovan za odkrivanje mutacij BRAF V600E in V600K z veliko senzitivnostjo (navzdol do 5 % sekvence V600E in V600K v ozadju sekvence divjega tipa ob uporabi DNA, pridobljene iz tkiva FFPE).
English: Effects of dabrafenib on substance transport systems
Slovenian: Vplivi dabrafeniba na transportne sisteme snovi
English: • floating spots before the eyes
Slovenian: • plavajoče pike pred očmi
English: Tell your doctor, pharmacist or nurse if you are taking any of these (or if you are not sure).
Slovenian: Zdravniku, farmacevtu ali medicinski sestri morate povedati, če jemljete katero od teh zdravil (ali če ste negotovi).
English: The median duration of follow-up (time from randomisation to last contact or death) was 2.83 years in the dabrafenib and trametinib combination arm and 2.75 years in the placebo arm.
Slovenian: Mediano trajanje spremljanja (čas od randomizacije do zadnjega kontakta z bolnikom oziroma njegove smrti) je bilo 2,83 let v skupini s kombinacijo dabrafeniba in trametiniba ter 2,75 let v skupini s placebom.
English: Taking the combination of Tafinlar and trametinib may increase the risk of developing holes in the gut wall.
Slovenian: Jemanje kombinacije zdravila Tafinlar in trametiniba lahko poveča tveganje za nastanek lukenj v steni črevesa.
English: Table 5 Kinase inhibitory activity of dabrafenib against RAF kinases
Slovenian: Preglednica 5 Kinazna inhibitorna aktivnost dabrafeniba proti RAF-kinazam
English: Red iron oxide (E172) Titanium dioxide (E171) Hypromellose (E464)
Slovenian: Ovojnica kapsule rdeči železov oksid (E172) titanov dioksid (E171) hipromeloza (E464)
English: Part B of study BRF113220 included a cohort of 26 patients that had progressed on a BRAF inhibitor.
Slovenian: Del B študije BRF113220 je vključeval kohorto s 26 bolniki, pri katerih je bolezen napredovala med predhodnim zdravljenjem z zaviralcem BRAF.
English: Unresectable or metastatic melanoma
Slovenian: Inoperabilni ali metastatski melanom
English: Both cancers have a particular change (mutation) in a gene called BRAF at the V600 position.
Slovenian: Pri obeh navedenih vrstah raka se pojavlja posebna sprememba (mutacija) gena z imenom BRAF na mestu V600.
English: NR = Not reached, NA = Not applicable
Slovenian: ND = ni doseženo, NA = ni relevantno
English: If the fever is severe, your doctor may recommend that you stop taking Tafinlar while they treat the fever with other medicines.
Slovenian: Če je telesna temperatura močno zvišana, lahko zdravnik naroči, da nehate jemati zdravilo Tafinlar, medtem ko zvišano telesno temperaturo zdravijo z drugimi zdravili.
English: If patients develop symptoms of pulmonary embolism or deep vein thrombosis such as shortness of breath, chest pain, or arm or leg swelling, they should immediately seek medical care.
Slovenian: Če se pri bolniku pojavijo znaki pljučne embolije ali globoke venske tromboze, kot so zadihanost, bolečine v prsnem košu ali zatekanje rok ali nog, mora takoj poiskati zdravniško pomoč.
English: Therefore, transient inhibition of CYP3A4 may be observed during the first few days of treatment.
Slovenian: Zato se lahko v prvih nekaj dneh zdravljenja pojavi prehodno zavrtje CYP3A4.
English: Stevens-Johnson syndrome Drug reaction with eosinophilia and systemic symptoms Dermatitis exfoliative generalised
Slovenian: Stevens-Johnsonov sindrom reakcija na zdravilo z eozinofilijo in sistemskimi simptomi (DRESS sindrom) generaliziran eksfoliativni dermatitis
English: How to take it Swallow the capsules whole with water, one after the other.
Slovenian: Kapsule zaužijte cele, z vodo, eno za drugo.
English: Pharmacotherapeutic group: Antineoplastic agents, protein kinase inhibitors, ATC code: L01XE23
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe (citostatiki), zaviralci protein-kinaze, oznaka ATC: L01XE23
English: Onset of induction is likely to occur after 3 days of repeat dosing with dabrafenib.
Slovenian: Pojav indukcije je verjeten po 3 dneh ponavljajočega se odmerjanja dabrafeniba.
English: Subjects with brain metastases were not included in the trial.
Slovenian: Bolniki z metastazami v možganih niso bili vključeni v študijo.
English: The bottles also include a silica gel desiccant in a small cylinder shaped container.
Slovenian: Plastenke vsebujejo tudi sušilo s silicijevim dioksidom v majhnem vsebniku cilindrične oblike.
English: Cases were managed with excision and did not require treatment modification (see section 4.4).
Slovenian: Zdravili so jih z ekscizijo in niso zahtevali prilagoditve zdravljenja (glejte poglavje 4.4).
English: • after eating, you must wait at least 2 hours before taking Tafinlar.
Slovenian: • morate po jedi počakati vsaj 2 uri, preden vzamete zdravilo Tafinlar.
English: Tafinlar is a medicine that contains the active substance dabrafenib.
Slovenian: Zdravilo Tafinlar je zdravilo, ki vsebuje učinkovino dabrafenib.
English: Patients on the DTIC arm were allowed to cross over to dabrafenib after independent radiographic confirmation of initial progression.
Slovenian: Bolniki v kraku z DTIC so po neodvisni radiografski potrditvi uvodnega napredovanja lahko prešli na dabrafenib.
English: The risk for liver injury after paracetamol administration is suspected to be higher in patients concomitantly treated with enzyme inducers.
Slovenian: Tveganje za okvaro jeter po uporabi paracetamola je domnevno večje pri bolnikih, ki sočasno prejemajo induktorje encimov.
English: Complete blood cell counts and blood chemistry should be performed as clinically indicated.
Slovenian: Opraviti je treba pregled celotne krvne slike in biokemične preiskave krvi, kot je klinično indicirano.
English: Patients with serious non-infectious febrile events responded well to dose interruption and/or dose reduction and supportive care.
Slovenian: Bolniki z resnimi neinfekcijskimi febrilnimi pojavi so se dobro odzvali na prekinitev uporabe in/ali znižanje odmerka ter podporno oskrbo.
English: The potential effect of dabrafenib on QT prolongation was assessed in a dedicated multiple dose QT study.
Slovenian: Možnost učinkovanja dabrafeniba na podaljšanje QT intervala so ocenjevali v posebni študiji za ovrednotenje QT intervala z več odmerki.
English: If you forget to take Tafinlar
Slovenian: Če ste pozabili vzeti zdravilo Tafinlar
English: Thus, trametinib and dabrafenib inhibit two kinases in this pathway, MEK and RAF, and therefore the combination provides concomitant inhibition of the pathway.
Slovenian: Trametinib in dabrafenib zavirata dve kinazi na tej poti, MEK in RAF, kombinacija zdravil torej sočasno zavira pot.
English: Please also read the trametinib package leaflet for details of the side effects you may get with trametinib.
Slovenian: Preberite tudi navodilo za uporabo za trametinib glede podrobnosti o neželenih učinkih, do katerih lahko pride zaradi trametiniba.
English: Neither dabrafenib nor its 3 main metabolites were demonstrated to be inhibitors of Pgp in vitro.
Slovenian: Niti za dabrafenib niti za tri njegove presnovke ni dokazano, da bi bili zaviralci Pgp in vitro.
English: • If you are a woman who could become pregnant you must use a reliable birth control method while you are taking Tafinlar and for at least 2 weeks after you stop taking it and for at least 16 weeks following the last dose of trametinib when given in combination with Tafinlar.
Slovenian: • Če ste ženska, ki bi lahko zanosila, morate med jemanjem zdravila Tafinlar in še vsaj 2 tedna po koncu jemanja tega zdravila oziroma še vsaj 16 tednov po zadnjem odmerku trametiniba, če ga uporabljate v kombinaciji z zdravilom Tafinlar, uporabljati zanesljivo kontracepcijsko zaščito.
English: Dabrafenib terminal half-life after a single oral dose is 8 hours due to absorption-limited elimination after oral administration (flip-flop pharmacokinetics).
Slovenian: Terminalni razpolovni čas dabrafeniba po enem samem peroralnem odmerku je 8 ur, in sicer zaradi absorpcijsko omejenega odstranjevanja po peroralni uporabi ("flip-flop farmakokinetika").
English: If possible, show them the Tafinlar pack with this leaflet.
Slovenian: Če je mogoče, jim pokažite pakiranje zdravila Tafinlar in to navodilo.
English: Usually, these skin changes remain local and can be removed with surgery and treatment with Tafinlar can be continued without interruption.
Slovenian: Po navadi ostanejo te spremembe kože lokalizirane in jih je mogoče odstraniti z operacijo ter nadaljevati zdravljenje z zdravilom Tafinlar brez prekinitve.
English: The primary endpoint was investigator-assessed relapse-free survival (RFS), defined as the time from randomisation to disease recurrence or death from any cause.
Slovenian: Primarni cilj opazovanja je bilo preživetje brez ponovitve bolezni (relapse-free survival, RFS) po oceni raziskovalca, ki je bilo opredeljeno kot čas od randomizacije do ponovitve bolezni ali smrti iz kateregakoli vzroka.
English: Cases of new primary melanoma can be managed with excision and do not require treatment modification.
Slovenian: V primeru novega primarnega melanoma je bolnika mogoče zdraviti z ekscizijo, spremembe v zdravljenju niso potrebne.
English: Adjuvant treatment of Stage III melanoma
Slovenian: Adjuvantno zdravljenje melanoma stadija III
English: Patients should take dabrafenib as monotherapy or in combination with trametinib at least one hour prior to or two hours after a meal due to the effect of food on dabrafenib absorption (see section 5.2).
Slovenian: Bolniki morajo dabrafenib, bodisi v monoterapiji ali v kombinaciji s trametinibom, vzeti vsaj eno uro pred jedjo ali vsaj dve uri po jedi, ker hrana vpliva na absorpcijo dabrafeniba (glejte poglavje 5.2).
English: Tell your doctor, pharmacist or nurse immediately if you get a fever (temperature 38.5ºC or above) while you are taking this medicine.
Slovenian: Zdravniku, farmacevtu ali medicinski sestri morate nemudoma povedati, če med jemanjem tega zdravila dobite zvišano telesno temperaturo (38,5 °C ali več).
English: Liver monitoring may be continued thereafter as clinically indicated.
Slovenian: Kontroliranje delovanja jeter se lahko nadaljuje, kot je klinično indicirano.
English: Subjects were enrolled into Cohort A (subjects with no prior local therapy for brain metastasis) or Cohort B (subjects who received prior local therapy for brain metastasis).
Slovenian: Bolniki so bili vključeni v kohorto A (bolniki brez predhodnega lokalnega zdravljenja metastaz na možganih) ali v kohorto B (bolniki, ki so pred tem že prejemali lokalno zdravljenje metastaz na možganih).
English: 24.6 (11.7, NE)
Slovenian: 24,6 (11,7; NO)
English: Rare side effects (may affect up to 1 in 1000 people) • A hole (perforation) in the stomach or intestines
Slovenian: Redki neželeni učinki (pojavijo se lahko pri največ 1 od 1000 bolnikov): • predrtje (perforacija) stene želodca ali črevesa
English: The primary endpoint of the study was overall intracranial response rate (OIRR) in the V600E patient population, as assessed by investigators.
Slovenian: Primarni opazovani dogodek študije je bil celotni delež intrakranialnega odziva (OIRR - overall intracranial response rate) v populaciji bolnikov z V600E po raziskovalčevi oceni.
English: • Increase in creatine phosphokinase, an enzyme found mainly in heart, brain, and skeletal muscle
Slovenian: • zvišana vrednost kreatin-kinaze, encima, ki je večinoma prisoten v srcu, možganih in skeletnih mišicah
English: Dabrafenib 438 405 + Trametinib
Slovenian: število izpostavljenih tveganju dabrafenib 438 405 + trametinib placebo
English: Before you take Tafinlar in combination with trametinib your doctor also needs to know if you:
Slovenian: Preden boste začeli jemati zdravilo Tafinlar v kombinaciji s trametinibom, mora vaš zdravnik vedeti tudi:
English: Medicinal products that alter the pH of the upper gastrointestinal (GI) tract (e.g. proton pump inhibitors, H2-receptor antagonists, antacids) are not expected to reduce the bioavailability of dabrafenib.
Slovenian: Ne pričakuje se, da bi zdravila, ki spreminjajo pH zgornjega gastrointestinalnega trakta (npr. zaviralci protonske črpalke, antagonisti histaminskih receptorjev H2, antacidi), zmanjšala biološko uporabnost dabrafeniba.
English: These results did not meet the pre-specified boundary to claim statistical significance at this first OS interim analysis (HR=0.50; p=0.000019).
Slovenian: Navedeni rezultati ne dosegajo vnaprej opredeljene omejitve za doseganje statistične značilnosti pri prvi vmesni analizi celokupnega preživetja (razmerje ogroženosti = 0,50; p = 0,000019).
English: The Kaplan-Meier OS curve appears to stabilise from 3 to 5 years (see Figure 2).
Slovenian: Videti je, da pride do stabilizacije Kaplan-Meierjeve krivulje za OS pri 3 do 5 letih (glejte sliko 2).
English: Some medicines may affect how Tafinlar works, or make it more likely that you will have side effects.
Slovenian: Nekatera zdravila lahko vplivajo na delovanje zdravila Tafinlar ali povečajo verjetnost neželenih učinkov.
English: • have or have had any gastrointestinal problems such as diverticulitis (inflamed pouches in the colon) or metastases to the gastrointestinal tract.
Slovenian: • če imate ali ste kdaj imeli težave s prebavili, kot so divertikulitis (vnetje žepkov v debelem črevesu) ali metastaze v prebavnem traktu.
English: Non-clinical and clinical trials with retrospective bi-directional Sanger sequencing analyses have shown that the test also detects the less common BRAF V600D mutation and V600E/K601E mutation with lower sensitivity.
Slovenian: Predklinične in klinične študije z retrospektivnimi analizami obojestranskega sekvenciranja po Sangerju so pokazale, da ta test odkrije tudi manj pogosti mutaciji BRAF V600D in mutacijo V600E/K601E z manjšo senzitivnostjo.
English: HR for recurrence = 0.49 95% CI (0.40, 0.59)
Slovenian: razmerje ogroženosti za ponovitev = 0,49 95% IZ (0,40; 0,59)
English: It is recommended that the doses of dabrafenib be taken at similar times every day, leaving an interval of approximately 12 hours between doses.
Slovenian: Priporočljivo je, da bolnik odmerek dabrafeniba vzame vsak dan ob približno istem času, presledek med odmerkoma pa naj bo približno 12 ur.
English: The desiccant must be kept inside the bottle and must not be eaten.
Slovenian: Sušilo mora ostati v plastenki in se ga ne sme zaužiti.
English: The Kaplan-Meier OS curve appears to stabilise from 3 to 5 years (see Figure 1).
Slovenian: Videti je, da pride do stabilizacije Kaplan-Meierjeve krivulje za OS pri 3 do 5 letih (glejte sliko 1).
English: Further, the capsules are printed with black ink that contains black iron oxide (E172) shellac and propylene glycol.
Slovenian: Poleg tega so oznake na kapsulah natisnjene s črnim črnilom, ki vsebuje črni železov oksid (E172), šelak in propilenglikol.
English: The other side effects that you may see when you take Tafinlar alone are as follows:
Slovenian: Drugi neželeni učinki, ki jih lahko opazite, če jemljete samo zdravilo Tafinlar so:
English: The primary objective for this study was to evaluate the efficacy of dabrafenib compared to DTIC with respect to PFS per investigator assessment.
Slovenian: Primarni cilj študije je bila ocena učinkovitosti dabrafeniba v primerjavi z DTIC, kar zadeva preživetje brez napredovanja bolezni (PFS) po raziskovalčevi oceni.
English: Secondary endpoints include overall survival (OS; key secondary endpoint), freedom from relapse (FFR) and distant metastasis-free survival (DMFS).
Slovenian: Med sekundarnimi cilji opazovanja so bili celokupno preživetje (OS; ključni sekundarni cilj opazovanja), stanje brez ponovitve bolezni (freedom from relapse, FFR) in preživetje brez oddaljenih metastaz (distant metastasis-free survival, DMFS).
English: This is to look for any new skin cancers.
Slovenian: Namen tega je, da bi odkril morebitne nove kožne rake.
English: If you stop taking Tafinlar
Slovenian: Če ste prenehali jemati zdravilo Tafinlar
English: The majority of subjects had Stage IV M1c disease (61% overall).
Slovenian: Pri večini preiskovancev je bil stadij bolezni IV M1c (skupno pri 61 %).
English: Not all pack sizes may be marketed in your country.
Slovenian: V vaši državi morda ni na trgu vseh navedenih pakiranj.
English: Women of childbearing potential must use effective methods of contraception during therapy and for 2 weeks following discontinuation of dabrafenib and 16 weeks following the last dose of trametinib when given in combination with dabrafenib.
Slovenian: Ženske v rodni dobi morajo uporabljati učinkovito kontracepcijo med zdravljenjem in še 2 tedna po prenehanju zdravljenja z dabrafenibom in še 16 tednov po zadnjem odmerku trametiniba, če ga uporabljajo v kombinaciji z dabrafenibom.
English: Carcinogenicity studies with dabrafenib have not been conducted.
Slovenian: Študij kancerogenosti z dabrafenibom niso izvedli.
English: • Increase in blood sugar level
Slovenian: • zvišana vrednost sladkorja v krvi
English: Taking Tafinlar or the combination of Tafinlar and trametinib may cause fever, although it is more likely if you are taking the combination treatment (see also section 4).
Slovenian: Jemanje zdravila Tafinlar ali kombinacije zdravila Tafinlar in trametiniba lahko povzroči zvišanje telesne temperature, pri čemer je verjetnost za to večja pri jemanju navedene kombinacije zdravil (glejte tudi poglavje 4).
English: However, these transporters have minimal impact on dabrafenib oral bioavailability and elimination and the risk for clinically relevant drug-drug interactions with inhibitors of Pgp or BCRP is low.
Slovenian: Vendar ta dva prenašalca le minimalno vplivata na biološko uporabnost in izločanje peroralno apliciranega dabrafeniba, tudi tveganje za klinično pomembno medsebojno delovanje z zaviralci Pgp ali BCRP je majhno.
English: Trametinib is a reversible, highly selective, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and kinase activity.
Slovenian: Trametinib je reverzibilen, visoko selektiven, alosterični zaviralec aktivacije in kinazne aktivnosti MEK1 in MEK2 (MEK - mitogeno aktivirana, z zunajceličnim signalom aktivirana kinaza).
English: OS data from a further post-hoc analysis based on the 18 December 2012 data cut demonstrated a 12-month OS rate of 63% and 70% for DTIC and dabrafenib treatments, respectively.
Slovenian: Podatki o celokupnem preživetju iz nadaljnje post hoc analize na podlagi podatkov do presečnega datuma 18. decembra 2012 so pokazali, da je stopnja 12-mesečnega celokupnega preživetja 63 % ob zdravljenju z DTIC in 70 % ob zdravljenju z dabrafenibom.
English: BRF115532 (COMBI-AD)
Slovenian: Študija BRF115532 (COMBI-AD)
English: Do not change your dose or stop Tafinlar or trametinib unless your doctor, nurse or pharmacist tells you to.
Slovenian: Ne spreminjajte odmerka in ne prekinjajte zdravljenja z zdravilom Tafinlar ali trametinibom, razen če vam tako naroči zdravnik, medicinska sestra ali farmacevt.
English: The majority of patients had a non-squamous histology.
Slovenian: Pri večini bolnikov je šlo za neploščatocelični histološki tip raka.