FrancophonIA/ELRC3.0 huggingface dataset:
English: in certain patients who have used antiretroviral medicines before (your doctor will determine this).
Danish: Dosis til voksne, som tidligere har fået hiv-medicin (din læge vil afgøre dette)
English: The recommended dose regimen is 800 mg once daily with ritonavir 100 mg once daily taken with food.
Danish: Den anbefalede dosis er 800 mg en gang dagligt sammen med ritonavir 100 mg en gang dagligt i forbindelse med et måltid.
English: A once daily dose regimen of darunavir taken with ritonavir taken with food may be used in patients with prior exposure to antiretroviral medicinal products but without darunavir resistance associated mutations (DRV-RAMs)* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: Et dosisregime med darunavir taget med ritonavir en gang dagligt i forbindelse med et måltid kan anvendes til patienter, der tidligere har været eksponeret for antiretrovirale lægemidler, men uden mutationer associeret med darunavirresistens (DRV-RAMs)*, og som har plasma-hiv-1-RNA < 100.000 kopier/ml og CD4+-celletal  100 x 10 celler /l.
English: Darunavir Krka might increase the risk for elevated potassium levels by drospirenone.
Danish: Darunavir Krka kan muligvis øge risikoen for forhøjet kaliumindhold i blodet pga. drospirenon.
English: During the second trimester of pregnancy, cobicistat Cmax, AUC24h, and Cmin were 50%, 63%, and 83% lower, respectively, as compared with postpartum.
Danish: I andet trimester af graviditeten var værdierne for Cmax, AUC24t og Cmin for cobicistat hhv. 50 %, 63 % og 83 % lavere i forhold til post partum.
English: Lopinavir/ritonavir 533/133.3 mg twice daily lopinavir AUC ↑ 9% lopinavir Cmin ↑ 23% lopinavir Cmax ↓ 2% darunavir AUC ↓ 38% darunavir Cmin ↓ 51% darunavir Cmax ↓ 21% lopinavir AUC ↔ lopinavir Cmin ↑ 13% lopinavir Cmax ↑ 11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% based upon non dose normalised values
Danish: Lopinavir/ritonavir 533/133,3 mg to gange daglig lopinavir AUC ↑ 9% lopinavir Cmin ↑ 23% lopinavir Cmax ↓ 2% darunavir AUC ↓ 38%‡ darunavir Cmin ↓ 51%‡ darunavir Cmax ↓ 21%‡ lopinavir AUC ↔ lopinavir Cmin ↑ 13% lopinavir Cmax ↑ 11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% baseret på ikkedosisnormaliserede værdier
English: Human experience of acute overdose with darunavir co-administered with cobicistat or low dose ritonavir is limited.
Danish: Der er kun begrænset erfaring med akut overdosering af darunavir, co-administreret med cobicistat eller lavdosis ritonavir, hos mennesker.
English: Postpartum (6-12 weeks) (n=12)
Danish: Post partum (6-12 uger) (n=12)
English: Method of administration
Danish: Samtidig administration af
English: Efficacy of darunavir 800 mg once daily co-administered with 100 mg ritonavir once daily in ARTnaïve patients
Danish: Virkning af darunavir 800 mg en gang dagligt co-administreret med 100 mg ritonavir en gang dagligt hos ART-naive patienter
English: Darunavir Krka is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) infection.
Danish: Darunavir Krka, anvendes til behandling af hiv-infektion (hiv: humant immundefektvirus).
English: Co administration of darunavir coadministered with cobicistat and bosentan is not recommended.
Danish: Co-administration af darunavir co-administreret med cobicistat og bosentan frarådes.
English: During the third trimester of pregnancy, cobicistat Cmax, AUC24h, and Cmin, were 27%, 49%, and 83% lower, respectively, as compared with postpartum.
Danish: I tredje trimester af graviditeten var værdierne for Cmax, AUC24t og Cmin for cobicistat hhv. 27 %, 49 % og 83 % lavere i forhold til post partum.
English: The combination of rifapentine and darunavir with concomitant low dose ritonavir is not recommended.
Danish: Kombinationen af rifapentin og darunavir med samtidig lavdosis ritonavir frarådes.
English: Musculoskeletal and connective tissue disorders uncommon myalgia, osteonecrosis, muscle spasms, muscular weakness, arthralgia, pain in extremity, osteoporosis, increased blood creatine phosphokinase rare musculoskeletal stiffness, arthritis, joint stiffness
Danish: Knogler, led, muskler og bindevæv ikke almindelig myalgi, osteonekrose, muskelspasmer, muskelsvaghed, artralgi, smerter i ekstremiteter, osteoporose, forhøjet kreatinphospho-kinase i blodet sjælden stivhed i skeletmuskulaturen, artritis, ledstivhed
English: # in the table below) have been performed at lower than recommended doses of darunavir or with a different dosing regimen (see section 4.2 Posology).
Danish: Adskillige af interaktionsstudierne (markeret med # i tabellen nedenfor) er gennemført med doser af darunavir, der er lavere end de anbefalede doser, eller med et andet doseringsregime (se pkt.
English: Take two 400 milligram tablets at the same time or one 800 miligram tablet, once a day, every day.
Danish: Anvisninger for voksne - Tag hver dag 2 tabletter på 400 mg på samme tidspunkt, eller 1 tablet på 800
English: 450 milligram darunavir + 60 milligram ritonavir twice a day more than 40 kilograms*
Danish: 450 mg Darunavir Krka + 60 mg ritonavir to gange dagligt mere end 40 kg*
English: 600 mg darunavir /100 mg ritonavir twice daily with ritonavir oral solution: 80 mg/ml
Danish: 600 mg darunavir/100 mg ritonavir to gange dagligt ritonavir oral opløsning: 80 mg/ml
English: Lopinavir/ritonavir 400/100 mg twice daily + OBR N=297
Danish: Lopinavir/ritonavir 400/100 mg to gange daglig + OBR N=297
English: Twice daily dosing Weight
Danish: Dosering to gange dagligt
English: Concomitant use of darunavir with low dose ritonavir and elbasvir/grazoprevir is contraindicated (see section 4.3).
Danish: Samtidig brug af darunavir med lavdosis ritonavir og elbasvir/grazoprevir er kontraindiceret (se pkt.
English: (CYP3A, CYP2D6 and/or P-gp inhibition)
Danish: (CYP3A, CYP2D6 og/eller Pgp-hæmning)
English: Alternative or additional contraceptive measures are recommended when oestrogen-based contraceptives are co-administered
Danish: Det anbefales at bruge andre eller supplerende svangerskabsforebyggende metoder, når østrogenbaserede kontraceptiva gives sammen med boostet darunavir.
English: The Summary of Product Characteristics of ritonavir must, therefore, be consulted prior to initiation of therapy with darunavir.
Danish: Produktresuméet for ritonavir skal derfor læses, inden behandling med darunavir påbegyndes.
English: 21 ART-experienced HIV-1 infected paediatric patients aged from 3 to < 6 years and weighing 10 kg to < 20 kg (16 participants from 15 kg to < 20 kg) who received darunavir oral suspension with low dose ritonavir twice daily in combination with other antiretroviral agents.
Danish: 21 ART-erfarne hiv-1-smittede pædiatriske patienter i alderen 3 til <6 år med en legemsvægt på 10 kg til <20 kg (16 deltagere fra 15 kg til <20 kg) som fik darunavir oral suspension med lavdosis ritonavir to gange daglig i kombination med andre antiretrovirale lægemidler.
English: Darunavir Krka might reduce its effectiveness.
Danish: Darunavir Krka kan nedsætte virkningen af disse.
English: Concomitant use of bosentan and boosted darunavir may increase plasma concentrations of bosentan.
Danish: Samtidig anvendelse af bosentan og boostet darunavir kan øge plasmakoncentrationen af bosentan.
English: Lovastatin and simvastatin are expected to have markedly increased plasma concentrations when coadministered with boosted darunavir.
Danish: Plasmakoncentrationen af lovastatin og simvastatin forventes at stige markant, når de gives sammen med boostet darunavir.
English: Number of subjects with virologic failure and paired baseline/endpoint phenotypes, showing loss of susceptibility to PIs at endpoint compared to baseline, n/N PI darunavir amprenavir atazanavir indinavir lopinavir saquinavir tipranavir
Danish: Antal deltagere med virologisk svigt og parrede fænotyper ved baseline/endepunkt, der udviste tab af følsomhed over for PI'er ved endepunktet sammenlignet med baseline, n/N
English: General disorders and administration site conditions common asthenia, fatigue uncommon pyrexia, chest pain, peripheral oedema, malaise, feeling hot, irritability, pain rare chills, abnormal feeling, xerosis
Danish: Almene symptomer og reaktioner på administrationsstedet almindelig asteni, træthed ikke almindelig pyrexi, brystsmerter, perifert ødem, utilpashed, varmefølelse, irritabilitet, smerte sjælden kulderystelse, unormal følelse, tørhed
English: Concominant administration of darunavir with low dose ritonavir and lurasidone, pimozide or sertindole is contraindicated (see section 4.3).
Danish: Samtidig administration af darunavir med lavdosis ritonavir og lurasidon, pimozid eller sertindol er kontraindiceret (se pkt.
English: Concomitant systemic use of clotrimazole and darunavir co-administered with low dose ritonavir may increase plasma concentrations of darunavir and/or clotrimazole.
Danish: Samtidig systemisk brug af clotrimazol og darunavir med samtidigt administreret lavdosis ritonavir kan øge plasmakoncentrationen af darunavir og/eller clotrimazol.
English: Gastrointestinal disorders very common diarrhoea common vomiting, nausea, abdominal pain, increased blood amylase, dyspepsia, abdominal distension, flatulence uncommon pancreatitis, gastritis, gastrooesophageal reflux disease, aphthous stomatitis, retching, dry mouth, abdominal discomfort, constipation, increased lipase, eructation, oral dysaesthesia rare stomatitis, haematemesis, cheilitis, dry lip, coated tongue
Danish: Mave-tarm-kanalen meget almindelig diarré almindelig opkastning, kvalme, abdominale smerter, forhøjet blodamylase, dyspepsi, abdominal distention, flatulens ikke almindelig pankreatitis, gastritis, gastroøsofageal reflukssygdom, aftøs stomatitis, opkastningsfornemmelser, mundtørhed, mavebesvær, forstoppelse, forhøjet lipase, ræben, oral dysæstesi sjælden stomatitis, hæmatemese, keilit, tørre læber, belægninger på tungen
English: CORTICOSTEROIDS
Danish: Andre kortikosteroider:
English: Boosted darunavir must not be used concomitantly with products containing St John's wort (Hypericum perforatum) (see section 4.3).
Danish: Boostet darunavir må ikke anvendes samtidig med produkter, der indeholder perikon (Hypericum perforatum) (se pkt.
English: Therefore, co-administration of darunavir with low dose ritonavir and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Danish: Co-administration af darunavir, lavdosis ritonavir og sildenafil til behandling af pulmonal arteriel hypertension er derfor kontraindiceret (se pkt.
English: The usual dose of Darunavir Krka is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) once daily.
Danish: Den sædvanlige dosis af Darunavir Krka er 800 mg (2 tabletter a 400 mg Darunavir Krka eller 1 tablet a 800 mg Darunavir Krka) en gang dagligt.
English: Renal impairment No dose adjustment is required in patients with renal impairment (see sections 4.4 and 5.2).
Danish: Der er ikke behov for dosisjustering hos patienter med nedsat nyrefunktion (se pkt.
English: 600 milligram Darunavir Krka (1 tablet containing 600 milligram of Darunavir Krka) together with 100 milligram ritonavir twice daily.
Danish: ELLER - 600 mg Darunavir Krka (1 tablet a 600 mg Darunavir Krka) sammen med 100 mg ritonavir to gange dagligt.
English: Concomitant use of boosted darunavir and elbasvir/grazoprevir is contraindicated (see section 4.3).
Danish: Samtidig brug af boostet darunavir og elbasvir/grazoprevir er kontraindiceret (se pkt.
English: A safe and effective dose of sildenafil for the treatment of pulmonary arterial hypertension co-administered with darunavir and low dose ritonavir has not been established.
Danish: En sikker og effektiv dosis af sildenafil til behandling af pulmonal arteriel hypertension administreret sammen med darunavir og lavdosis ritonavir.er ikke fastlagt.
English: Concominant administration of boosted darunavir and lurasidone, pimozide or sertindole is contraindicated (see section 4.3).
Danish: Samtidig administration af boostet darunavir og lurasidon, pimozid eller sertindol er kontraindiceret (se pkt.
English: Clinical monitoring is recommended when co-administering darunavir with low dose ritonavir with these analgesics.
Danish: Klinisk monitoring anbefales ved administration af boostet darunavir og lavdosis ritonavir sammen med disse analgetika.
English: Darunavir should not be used in paediatric patients below 3 years of age or less than 15 kg body weight (see sections 4.4 and 5.3).
Danish: Darunavir bør ikke anvendes til pædiatriske patienter under 3 år eller med en legemsvægt under 15 kg (se pkt.
English: Darunavir Krka 800 mg film-coated tablets (tablets):
Danish: Darunavir Krka 800 mg filmovertrukne tabletter (tabletter):
English: Respiratory, thoracic and mediastinal disorders uncommon dyspnoea, cough, epistaxis, throat irritation rare rhinorrhoea
Danish: Luftveje, thorax og mediastinum ikke almindelig dyspnø, hoste, næseblødning, halsirritation sjælden næseflåd
English: Darunavir Krka 400 mg and 800 mg tablets can be used to construct the once daily 800 mg regimen.
Danish: Darunavir Krka 400 mg og 800 mg tabletter kan anvendes til at sammensætte regimet med 800 mg en gang dagligt.
English: Concomitant systemic use of clotrimazole and boosted darunavir may increase plasma concentrations of darunavir and/or clotrimazole.
Danish: Samtidig systemisk brug af clotrimazol og boostet darunavir kan øge plasmakoncentrationen af darunavir og/eller clotrimazol.
English: Concomitant use of salmeterol and darunavir co-administered with low dose ritonavir is not recommended.
Danish: Samtidig anvendelse af salmeterol og darunavir administreret sammen med lavdosis ritonavir anbefales ikke.
English: At 48 weeks non-inferiority in virologic response to the darunavir/ritonavir treatment, defined as the percentage of patients with plasma HIV-1 RNA level < 400 and < 50 copies/ml, was demonstrated (at the pre-defined 12% non-inferiority margin) for both ITT and OP populations.
Danish: Ved 48 uger blev non-inferioritet i virologisk respons over for darunavir/ritonavirbehandlingen, defineret som procentdelen af patienter med plasma hiv-1-RNA-niveau < 400 og < 50 kopier/ml, påvist (ved den forud definerede 12 % grænse for noninferioritet) hos begge populationer (”Intent-To-Treat” og ”On Protocol”).
English: Darunavir is not recommended for use in paediatric patients below 3 years of age or less than 15 kg body weight (see sections 4.2 and 5.3).
Danish: Darunavir anbefales ikke til brug til pædiatriske patienter under 3 år eller med en legemsvægt under 15 kg (se pkt.
English: Rifapentine and rifampicin are strong CYP3A inducers and have been shown to cause profound decreases in concentrations of other protease inhibitors, which can result in virological failure and resistance development (CYP450 enzyme induction).
Danish: Rifapentin og rifampicin er potente CYP3Ainduktorer, som er vist at forårsage et væsentligt fald i koncentrationen af andre proteasehæmmere.
English: The effect of severe hepatic impairment on the pharmacokinetics of darunavir has not been studied (see sections 4.2, 4.3 and 4.4).
Danish: Effekten af svært nedsat leverfunktion på farmakokinetikken for darunavir er ikke blevet undersøgt (se pkt.
English: 30 film-coated tablets: EU/1/17/1249/009 90 film-coated tablets: EU/1/17/1249/010
Danish: 30 filmovertrukne tabletter: EU/1/17/1249/009 90 filmovertrukne tabletter: EU/1/17/1249/010
English: For information on cobicistat, consult the cobicistat Summary of Product Characteristics.
Danish: For oplysninger om cobicistat, se produktresuméet for cobicistat.
English: Interaction Geometric mean change (%)
Danish: Interaktion Geometrisk middelændring
English: If efavirenz is to be used in combination with darunavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used.
Danish: Hvis efavirenz skal anvendes i kombination med darunavir, bør der anvendes et regime med darunavir/ritonavir 600/100 mg to gange daglig.
English: Please contact your doctor whenever you develop a rash.
Danish: Kontakt din læge, hvis du får hududslæt.
English: 800 mg darunavir/100 mg ritonavir once daily ritonavir oral solution: 80 mg/ml
Danish: 800 mg darunavir/100 mg ritonavir en gang dagligt ritonavir oral opløsning: 80 mg/ml
English: This can be seen in a blood test. high blood pressure, flushing red or dry eyes fever, swelling of lower limbs due to fluids, malaise, irritability, pain symptoms of infection, herpes simplex erectile dysfunction, enlargement of breasts sleeping problems, sleepiness, depression, anxiety, abnormal dreams, decrease in sexual drive
Danish: knogleskørhed - nedsættelse af skjoldbruskkirtlens funktion.Dettekan ses ved en blodprøve - forhøjet blodtryk, rødme - røde eller tørre øjne - feber, hævede ben på grund af væske, utilpashed, irritabilitet, smerte - symptomer på infektion, herpes simplex - impotens, større bryster - søvnproblemer, søvnighed, depression, angst, unormale drømme, nedgang i seksuallyst.
English: Darunavir must always be given orally with cobicistat or low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products (see section 5.2).
Danish: Darunavir skal altid gives oralt med cobicistat eller lavdosis ritonavir som en farmakokinetisk forstærker og i kombination med andre antiretrovirale lægemidler (se pkt.
English: ART-experienced with no darunavir resistance associated mutations (DRV-RAMs) and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: - ART-erfarne uden mutationer associeret med darunavirresistens (DRV-RAMs), og som har plasma hiv-1-RNA < 100.000 kopier/ml og CD4+-celletal ≥ 100 x 6 celler/l.
English: 12 ART-naïve HIV-1 infected paediatric patients aged from 12 to 17 years and weighing at least 40 kg who received darunavir tablets with low dose ritonavir once daily in combination with other antiretroviral agents (see section 5.1).
Danish: 12 ART-naive hiv-1-smittede pædiatriske patienter i alderen 12 til 17 år med en legemsvægt på mindst 40 kg, som fik darunavir tabletter sammen med lavdosis ritonavir en gang daglig i kombination med andre antiretrovirale lægemidler (se pkt.
English: In women receiving darunavir/ritonavir 600/100 mg twice daily during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC12h and Cmin were 28%, 26% and 26% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC12h and Cmin values were 18%, 16% lower and 2% higher, respectively, as compared with postpartum.
Danish: Hos kvinder, der fik 600/100 mg darunavir/ritonavir to gange dagligt i andet trimester af graviditeten, var de gennemsnitlige intraindividuelle værdier for Cmax, AUC12t og Cmin for total-darunavir hhv. 28 %, 26 % og 26 % lavere i forhold til post partum.
English: Co-administration of boosted darunavir with dapoxetine is contraindicated.
Danish: Co-administration af boostet darunavir og dapoxetin er kontraindiceret.
English: Co-administration with herbal preparations containing St John's wort (Hypericum perforatum) (see section 4.5).
Danish: Samtidig administration af naturlægemidler, der indeholder perikon (Hypericum perforatum) (se pkt.
English: Co-administration of darunavir/ritonavir with medicinal products primarily metabolised by CYP3A and/or CYP2D6 or transported by P-gp may result in increased systemic exposure to such medicinal products, which could increase or prolong their therapeutic effect and adverse reactions.
Danish: Co-administration af darunavir/ritonavir med lægemidler, der især metaboliseres af CYP3A og/eller CYP2D6 eller transporteres af P-gp, kan forårsage øget systemisk eksponering for sådanne lægemidler, hvilket kan øge eller forlænge både den terapeutiske virkning og bivirkninger.
English: EU/1/17/1249/009 30 film-coated tablets EU/1/17/1249/010 90 film-coated tablets
Danish: EU/1/17/1249/009 30 filmovertrukne tabletter EU/1/17/1249/010 90 filmovertrukne tabletter
English: Clinical monitoring is recommended when co-administering boosted darunavir with these analgesics.
Danish: Klinisk monitoring anbefales ved administration af boostet darunavir sammen med disse analgetika.
English: Nucleo(s/t)ide reverse transcriptase inhibitors (NRTIs) Didanosine
Danish: Nukleosid-revers-transkriptase-hæmmere (NRTI'er) Didanosin
English: UROLOGICAL DRUGS Fesoterodine Solifenacin
Danish: UROLOGISKE LÆGEMIDLER Fesoterodin
English: Boosted darunavir and didanosine can be used without dose adjustments.
Danish: Boostet darunavir og didanosin kan administreres uden dosisjusteringer.
English: Third Trimester of pregnancy (n=15)
Danish: Tredje trimester af graviditeten (n=15)
English: Last Observation Carried Forward imputation
Danish: Tilregning af LOCF (sidste overførte observation)
English: darunavir /ritonavir 10 kg to < 15 kg N=5
Danish: 10 kg til <15 kg N=5
English: Boosted darunavir can be coadministered with proton pump inhibitors without dose adjustments.
Danish: Boostet darunavir kan administreres sammen med protonpumpehæmmere uden dosisjusteringer.
English: Therefore, darunavir must only be used in combination with a pharmacokinetic enhancer (see sections 4.4 and 5.2).
Danish: Derfor må darunavir kun anvendes i kombination med en farmakokinetisk forstærker (se pkt.
English: Concomitant use of bosentan and darunavir co-administered with low dose ritonavir may increase plasma concentrations of bosentan.
Danish: Samtidig anvendelse af bosentan og darunavir administreret sammen med lavdosis ritonavir kan øge plasmakoncentrationen af bosentan.
English: ART-experienced paediatric patients from the age of 6 to < 18 years and weighing at least 20 kg DELPHI is an open-label, Phase II trial evaluating the pharmacokinetics, safety, tolerability, and efficacy of darunavir with low dose ritonavir in 80 ART-experienced HIV-1 infected paediatric patients aged 6 to 17 years and weighing at least 20 kg.
Danish: DELPHI er et åben label fase II studie, hvor farmakokinetikken, sikkerheden, tolerabiliteten og effekten af darunavir med lavdosis ritonavir blev undersøgt hos 80 ART-erfarne hiv-1-smittede pædiatriske patienter i alderen 6 til 17 år og med en vægt på mindst 20 kg.
English: ANTICOAGULANT/PLATELET AGGREGATION INHIBITOR Apixaban
Danish: ANTIKOAGULANTIA/TROMBOCYTHÆMMENDE MIDLER Apixaban
English: Co-administration of darunavir and ritonavir and medicinal products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Danish: Co-administration af darunavir og ritonavir og lægemidler, som primært metaboliseres af CYP2C9 (såsom warfarin) og CYP2C19 (såsom metadon) kan resultere i nedsat systemisk eksponering af disse lægemidler, hvilket kan nedsætte eller forkorte deres terapeutiske effekt.
English: Concomitant use of everolimus and boosted darunavir is not recommended.
Danish: Samtidig brug af everolimus og boostet darunavir frarådes.
English: 6/l (see section 4.2 and 4.4).
Danish: 4.2, 4.3 og 4.4).
English: Co-administration of darunavir and ritonavir with medicinal products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Danish: Co-administration af darunavir og ritonavir med lægemidler, som primært metaboliseres af CYP2C9 (såsom warfarin) og CYP2C19 (såsom metadon) kan resultere i nedsat systemisk eksponering af disse lægemidler, hvilket kan nedsætte eller forkorte deres terapeutiske effekt.
English: Concominant use of everolimus or irinotecan and boosted darunavir is not recommended.
Danish: Samtidig brug af everolimus eller irinotecan og boostet darunavir frarådes.
English: Concominant use of everolimus or irinotecan and darunavir coadministered with low dose ritonavir is not recommended.
Danish: Samtidig brug af everolimus eller irinotecan og darunavir coadministreret med lavdosis ritonavir frarådes.
English: 450 mg darunavir /60 mg ritonavir twice daily
Danish: 450 mg darunavir/60 mg ritonavir to gange dagligt