FrancophonIA/ELRC3.0 huggingface dataset:
English: If you take too many tablets, or if someone else takes your medicine, contact your doctor immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Ipreziv, kot bi smeli Če ste vzeli preveč tablet ali če je kdo drug vzel vaše zdravilo, takoj pokličite svojega zdravnika.
English: For Ipreziv, olmesartan medoxomil and valsartan, respectively dizziness was observed at an incidence of 3.0%, 3.3% and 1.8%; headache at 4.8%, 5.5% and 7.6% and dyslipidemia at 3.5%, 2.4% and 1.1%.
Slovenian: Za zdravilo Ipreziv, medoksomilolmesartanat in valsartan je bila omotica opažena s pogostnostjo 3,0 %, 3,3 % in 1,8 %, glavobol s pogostnostjo 4,8 %, 5,5 % in 7,6 % ter dislipidemija s pogostnostjo 3,5 %, 2,4 % in 1,1 %.
English: Ipreziv was compared with placebo and active comparators in two 6-week randomized, double blind studies.
Slovenian: Zdravilo Ipreziv so primerjali s placebom in primerjalnimi učinkovinami v dveh 6-tedenskih randomiziranih, dvojno slepih študijah.
English: Pack sizes: One blister pack contains either 14 tablets or 15 tablets.
Slovenian: En pretisni omot vsebuje 14 ali 15 tablet.
English: - Hypersensitivity to the active substance or to any of the excipients.
Slovenian: - Preobčutljivost na zdravilno učinkovino ali katerokoli pomožno snov.
English: Ipreziv is provided in blister packs with each blister pack having either 14 tablets or 15 tablets within cartons containing: - 14, 28, 30, 56, 90 or 98 tablets for 20 mg tablets - 14, 28, 30, 56, 90 or 98 tablets for 40 mg tablets - 14, 28, 30, 56, 90 or 98 tablets for 80 mg tablets
Slovenian: V enem pretisnem omotu je 14 ali 15 tablet, ena škatla pa vsebuje: - 14, 28, 30, 56, 90 ali 98 tablet po 20 mg - 14, 28, 30, 56, 90 ali 98 tablet po 40 mg - 14, 28, 30, 56, 90 ali 98 tablet po 80 mg
English: Small mean increases of serum uric acid were observed with Ipreziv (10.8 µmol/l) compared with placebo (4.3 µmol/l).
Slovenian: Manjše povečanje srednje vrednosti sečne kisline v serumu so opazili pri zdravilu Ipreziv (10,8 mol/l) v primerjavi s placebom (4,3 mol/l).
English: Takeda Pharma A/S, Dybendal Alle 10, 2630 Taastrup, Denmark Manufacturer:
Slovenian: Takeda Pharma A/S, Dybendal Alle 10, 2630 Taastrup, Danska Izdelovalec:
English: Pharmacotherapeutic group: Angiotensin II antagonists, plain ATC Code: C09CA09
Slovenian: Farmakoterapevtska skupina: Antagonisti angiotenzina II, enokomponentna zdravila, oznaka ATC: C09CA09
English: Primary End point:
Slovenian: Primarni opazovani dogodek:
English: Following an oral dose of 14C-labelled azilsartan medoxomil, approximately 55% of radioactivity was recovered in feces and approximately 42% in urine, with 15% of the dose excreted in urine as azilsartan.
Slovenian: Po peroralnem odmerku s 14C-označenega medoksomilazilsartanata je bilo 55 % radioaktivnosti ugotovljene v blatu in približno 42 % v urinu.
English: In seven double blind controlled studies, a total of 5941 patients (3672 given Ipreziv, 801 given placebo, and 1468 given active comparator) were evaluated.
Slovenian: V sedmih dvojno slepih kontroliranih študijah je bilo skupaj vključenih 5.941 bolnikov (3.672 jih je prejemalo zdravilo Ipreziv, 801 jih je prejemalo placebo, 1.468 pa jih je prejemalo primerjalno učinkovino).
English: Based on its pharmacodynamic properties it is expected that azilsartan medoxomil would have negligible influence on the ability to drive and use machines.
Slovenian: Na podlagi farmakodinamičnih lastnosti je pričakovati, da bi lahko imel medoksomilazilsartanat zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: croscarmellose sodium, microcrystalline cellulose, and magnesium stearate.
Slovenian: premreženi natrijev karmelozat, mikrokristalna celuloza in magnezijev stearat.
English: Fumaric acid (E 297) Sodium hydroxide Hydroxypropylcellulose (E 463) Croscarmellose sodium Cellulose, microcrystalline (E 460) Magnesium stearate (E 572)
Slovenian: 6.1 Seznam pomožnih snovi manitol (E 421) fumarna kislina (E 297) natrijev hidroksid hidroksipropilceluloza (E 463) premreženi natrijev karmelozat mikrokristalna celuloza (E 460) magnezijev stearat (E 572)
English: - have diabetes mellitus or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Slovenian: - imate sladkorno bolezen ali okvarjeno delovanje ledvic in se zdravite z zdravilom za znižanje krvnega tlaka, ki vsebuje aliskiren.
English: In active-comparator studies with either valsartan or ramipril, the blood-pressure-lowering effect with Ipreziv was sustained during long-term treatment.
Slovenian: V primerjalnih študijah z valsartanom ali ramiprilom, se je učinek znižanja krvnega tlaka z zdravilom Ipreziv ohranjal pri dolgotrajnem zdravljenju.
English: Ipreziv at doses of 20, 40 or 80 mg has been evaluated for safety in clinical studies in patients treated for up to 56 weeks.
Slovenian: Povzetek varnostnega profila Varnost zdravila Ipreziv v odmerkih po 20, 40 ali 80 mg je bilo opredeljena s kliničnimi študijami pri bolnikih v trajanju do 56 tednov.
English: Coadministration of Ipreziv 40 and 80 mg with a calcium channel blocker (amlodipine) or a thiazidetype diuretic (chlortalidone) resulted in additional blood pressure reductions compared with the other antihypertensive alone.
Slovenian: Sočasna uporaba 40 in 80 mg zdravila Ipreziv z zaviralci kalcijevih kanalčkov (amlodipin) ali z diuretiki tiazidnega tipa (klortalidon) je v primerjavi z zdravljenjem z drugim antihipertenzivom samim pokazala dodatna znižanja krvnega tlaka.
English: In the repeated-dose toxicity studies, doses producing exposure comparable to that in the clinical therapeutic range caused reduced red cell parameters, changes in the kidney and renal haemodynamics, as well as increased serum potassium in normotensive animals.
Slovenian: V študijah toksičnosti pri ponovljenih odmerkih so odmerki, ki so povzročili izpostavljenost, primerljivo s tisto v kliničnem terapevtskem območju, povzročili zmanjšanje parametrov rdečih krvničk, spremembe v ledvicah in hemodinamike ledvic, kakor tudi povečanje koncentracije kalija v serumu pri živalih z normalnim krvnim tlakom.
English: Near-maximal antihypertensive effect is evident at 2 weeks, with maximal effects attained by 4 weeks.
Slovenian: Skoraj najvišji antihipertenzivni učinek se pokaže v 2 tednih, največji učinki pa so doseženi po
English: Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
English: Ipreziv is not recommended in early pregnancy, and must NOT be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Slovenian: Uporaba zdravila Ipreziv ni priporočljiva v zgodnjem obdobju nosečnosti in ga NE smete jemati, če ste noseči dlje kot 3 mesece, ker lahko v tem obdobju resno škoduje vašemu otroku (glejte poglavje o nosečnosti).
English: Ipreziv is not recommended in early pregnancy, and must NOT be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Slovenian: Zdravilo Ipreziv v zgodnji nosečnosti ne priporočajo; NE smete pa ga jemati, ko boste noseči dlje kot 3 mesece, ker lahko po tretjem mesecu nosečnosti resno škoduje vašemu otroku.
English: Rare side effects affecting less than 1 in 1000 people: - Changes in blood test results including decreased levels of a protein in the red blood cells
Slovenian: Redki neželeni učinki (pojavijo se pri manj kot 1 od 1.000 bolnikov): - spremembe vrednosti krvnih preiskav, vključno z znižanjem vrednosti beljakovine v
English: Read all of this leaflet carefully before you start taking this medicine because it contains
Slovenian: Pred začetkom jemanja zdravila natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
English: There is no experience with the use of Ipreziv in children or adolescents under 18 years of age.
Slovenian: Izkušenj z uporabo zdravila Ipreziv pri otrocih in mladostnikih, mlajših od 18 let, ni.
English: Therefore, adequate hydration and monitoring of renal function at the beginning of the treatment are recommended.
Slovenian: Zato je na začetku zdravljenja priporočljiv nadzor delovanje ledvic,
English: The blood pressure lowering effect of Ipreziv was also maintained throughout the 24-hour dosing interval.
Slovenian: Učinek znižanja krvnega tlaka zdravila Ipreziv se je ohranjal v vsem 24urnem intervalu jemanja odmerka.
English: The elevations in serum creatinine during coadminstiration of Ipreziv with diuretics were associated with larger blood pressure reductions compared with a single medicinal product.
Slovenian: Dvigi koncentracij serumskega kreatinina pri sočasnem jemanju zdravila Ipreziv z diuretiki so bili povezani z večjimi znižanji krvnega tlaka, v primerjavi z jemanjem enega samega zdravila.
English: Ipreziv has not been studied in patients with severe hepatic impairment.
Slovenian: Zdravilo Ipreziv ni bilo raziskano pri bolnikih s hudo jetrno okvaro.
English: As with other angiotensin II receptor antagonists and angiotensin converting enzyme inhibitors the antihypertensive effect was lower in black patients (usually a lowrenin population).
Slovenian: Kot pri drugih antagonistih angiotenzina II in zaviralcih angiotenzinske konvertaze je antihipertenzivni učinek nižji pri temnopoltih bolnikih (običajno je to populacija z nizkim reninom).
English: If you forget to take Ipreziv Do not take a double dose to make up for a forgotten dose.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: As with all other angiotensin II receptor antagonist medicines, azilsartan medoxomil may be less effective in lowering the blood pressure in black patients.
Slovenian: Kot velja za vse druge antagoniste angiotenzina II, je tudi medoksomilazilsartanat lahko manj učinkovit pri nižanju krvnega tlaka pri temnopoltih bolnikih.
English: During controlled clinical studies in healthy subjects, once daily doses up to 320 mg of Ipreziv were administered for 7 days and were well tolerated.
Slovenian: V kontroliranih kliničnih študijah so udeleženci 7 dni prejemali enkratni dnevni odmerek 320 mg zdravila Ipreziv, ki so ga dobro prenašali.
English: Method of administration Ipreziv is for oral use and may be taken with or without food (see section 5.2).
Slovenian: Zdravilo Ipreziv se jemlje peroralno, s hrano ali brez nje (glejte poglavje 5.2).
English: Ipreziv is for oral use.
Slovenian: Zdravilo Ipreziv je za peroralno uporabo.
English: Systemic exposures to the major and minor metabolites in humans were approximately 50% and less than 1% that of azilsartan, respectively.
Slovenian: Sistemska izpostavljenost glavnemu in stranskemu presnovku v primerjavi z azilsartanom je bila pri človeku 50 % oz. manj kot
English: The incidence of elevations in serum creatinine following treatment with Ipreziv was similar to placebo in the randomised placebo-controlled monotherapy studies.
Slovenian: Pogostnost zvišanih koncentracij serumskega kreatinina po zdravljenju z zdravilom Ipreziv je bila v randomizirani, s placebom kontrolirani študiji monoterapije podobna kot pri placebu.
English: Ipreziv is indicated for the treatment of essential hypertension in adults.
Slovenian: 4.1 Terapevtske indikacije Zdravilo Ipreziv je indicirano za zdravljenje esencialne hipertenzije pri odraslih.
English: When Ipreziv was coadministered with amlodipine, the frequency of peripheral oedema was increased from uncommon to common, but was lower than amlodipine alone.
Slovenian: Pri sočasni uporabi zdravila Ipreziv in amlodipina se je pogostnost perifernega edema z občasne povečala na pogosto, vendar pa je bila nižja kot pri uporabi amlodipina samega.
English: Additionally, Ipreziv 80 mg resulted in significantly greater reductions in SBP than the highest approved doses of olmesartan medoxomil and valsartan.
Slovenian: 80 mg pokazalo pomembno večje znižanje sistoličnega krvnega tlaka (SKT) kot največji dovoljeni odmerki medoksomilolmesartanata in valsartana.
English: Like all medicines, Ipreziv can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila, ima lahko tudi to zdravilo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Administration of Ipreziv for up to 5 days in subjects with mild (Child-Pugh A) or moderate (ChildPugh B) hepatic impairment resulted in slight increase in azilsartan exposure (AUC increased by 1.3 to 1.6 fold, see section 4.2).
Slovenian: Dajanje zdravila Ipreziv bolnikom z blago (Child-Pugh A) ali zmerno (Child-Pugh B) jetrno okvaro v trajanju 5 dni, je pokazalo majhno povečanje izpostavljenosti azilsartanu (AUC se je povečala za 1,3
English: - The concomitant use of Ipreziv with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73m2) (see sections 4.5 and 5.1).
Slovenian: - Sočasna uporaba zdravila Ipreziv in zdravil, ki vsebujejo aliskiren, je kontraindicirana pri bolnikih s sladkorno boleznijo ali okvaro ledvic (hitrost glomerularne filtracije < 60 ml/min/1,73 m2) (glejte poglavji 4.5 in 5.1).
English: The antihypertensive effect of Ipreziv occurred within the first 2 weeks of dosing with the full effect achieved by 4 weeks.
Slovenian: Antihipertenzivni učinek zdravila Ipreziv se je pokazal v prvih dveh tednih zdravljenja, poln učinek pa je bil dosežen v štirih tednih.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Ipreziv in one or more subsets of the paediatric population in hypertension (see section 4.2 for information on paediatric use).
Slovenian: Ipreziv za eno ali več podskupin pediatrične populacije s hipertenzijo (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Do not use Ipreziv after the expiry date which is stated on the carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Hypotension in volume- and /or salt-depleted patients In patients with marked volume- and/or salt-depletion (e.g. patients with vomiting, diarrhoea or taking high doses of diuretics) symptomatic hypotension could occur after initiation of treatment with Ipreziv.
Slovenian: Hipotenzija in bolniki z zmanjšanim volumnom in/ali izgubo soli Pri bolnikih z izrazitim zmanjšanim volumnom ali z izgubo soli (npr. pri bolnikih, ki bruhajo, imajo drisko ali jemljejo visoke odmerke diuretikov) lahko po začetku zdravljenja z zdravilom Ipreziv pride do pojava simptomatične hipotenzije.
English: Do NOT take Ipreziv if you - are allergic (hypersensitive) to azilsartan medoxomil or any of the other ingredients of Ipreziv (see section 6).
Slovenian: NE jemljite zdravila Ipreziv, če - ste alergični na medoksomilazilsartanat ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING
Slovenian: B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z
English: IPREZIV 20 MG TABLETS IPREZIV 40 MG TABLETS IPREZIV 80 MG TABLETS
Slovenian: Ipreziv 20 mg tablete Ipreziv 40 mg tablete Ipreziv 80 mg tablete medoksomilazilsartanat
English: Because no information is available regarding the use of Ipreziv during breastfeeding, Ipreziv is not recommended and alternative treatments with better established safety profiles during breastfeeding are preferable, especially while nursing a newborn or preterm infant.
Slovenian: Ker o uporabi zdravila Ipreziv med dojenjem ni podatkov, ga ne priporočajo, zato je treba med dojenjem, še zlasti med dojenjem novorojenčkov ali prezgodaj rojenih dojenčkov, dati prednost alternativnim zdravilom z uveljavljenim varnostnim profilom za uporabo med dojenjem.
English: This effect is also seen with other inhibitors of the renin-angiotensin-aldosterone system.
Slovenian: Ta učinek je bil opažen tudi pri drugih zaviralcih sistema renin-angiotenzin-aldosteron.
English: Dose dependent adverse events including dizziness, hypotension and serum creatinine elevations were more frequent with diuretic coadministration compared with Ipreziv alone, while hypokalemia was less frequent compared with diuretic alone.
Slovenian: Od odmerka odvisni neželeni učinki, kot so omotica, hipotenzija in zvišana serumska koncentracija kreatinina, so bili pogostejši pri sočasnem dajanju diuretika kot pri zdravljenju samo z zdravilom Ipreziv, medtem ko je bila hipokaliemija manj pogosta kot pri zdravljenju samo z diuretikom.
English: - Heparin (a medicine for thinning the blood) - Diuretics (water tablets) - Aliskiren or other medicines to lower your blood pressure (angiotensin converting enzyme inhibitor or angiotensin II receptor blocker, such as enalapril, lisinopril, ramipril or valsartan,
Slovenian: - diuretike (zdravila za odvajanje vode), - aliskiren ali druga zdravila za nižanje krvnega tlaka (zaviralci angiotenzinske konvertaze ali antagonisti angiotenzina II, kot so enalapril, lizinopril, ramipril ali valsartan, telmisartan, irbesartan).
English: In patients whose vascular tone and renal function depend predominantly on the activity of the reninangiotensin-aldosterone system (e.g. patients with congestive heart failure, severe renal impairment or renal artery stenosis), treatment with medicinal products that affect this system, such as angiotensinconverting enzyme inhibitors and angiotensin II receptor antagonists, has been associated with acute hypotension, azotaemia, oliguria or, rarely, acute renal failure.
Slovenian: Pri bolnikih, pri katerih sta žilni tonus in delovanje ledvic odvisna predvsem od delovanja sistema renin-angiotenzin-aldosteron (npr. pri bolnikih s kongestivnim srčnim popuščanjem, hudo ledvično okvaro ali stenozo ledvične arterije) je bilo zdravljenje z zdravili, ki vplivajo na ta sistem, kot so zaviralci angiotenzinske konvertaze ali antagonisti angiotenzina II, povezano z akutno hipotenzijo, azotemijo, oligurijo ali redkeje, z akutno odpovedjo ledvic.
English: Doses were force-titrated at Week 2 from 20 to 40 mg and 40 to 80 mg for Ipreziv, and 20 to 40 mg and 160 to 320 mg, respectively, for olmesartan medoxomil and valsartan
Slovenian: 40 na 80 mg zdravila Ipreziv, ter z 20 na 40 mg medoksomilolmesartanata oz. s 160 na 320 mg valsartana.
English: When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti in, če je primerno, začeti alternativno zdravljenje (glejte poglavji 4.3 in
English: STOP taking Ipreziv and seek medical help immediately if you have any of the following allergic reactions, which occur rarely (less than 1 in 1000 people): - Difficulties in breathing, or swallowing, or swelling of the face, lips, tongue and/or throat
Slovenian: PRENEHAJTE z jemanjem zdravila Ipreziv in takoj poiščite zdravniško pomoč, če opazite katero od naslednjih alergičnih reakcij, ki se pojavijo redko (pri manj kot 1 od 1.000 bolnikov):
English: Hypovolemia should be corrected prior to administration of Ipreziv, or the treatment should start under close medical supervision, and consideration can be given to a starting dose of 20 mg.
Slovenian: Hipovolemijo je potrebno pred dajanjem zdravila Ipreziv odpraviti, ali pa je treba zdravljenje uvesti pod skrbnim zdravniškim nadzorom.
English: If blood pressure is not adequately controlled with Ipreziv alone, additional blood pressure reduction can be achieved when Ipreziv is coadministered with other antihypertensive medicinal products, including diuretics (such as chlortalidone and hydrochlorothiazide) and calcium channel blockers (see sections 4.3, 4.4, 4.5 and 5.1).
Slovenian: Če zdravilo Ipreziv samo ne zagotovi ustreznega uravnavanja krvnega tlaka, se lahko dodatno znižanje krvnega tlaka doseže tako, da se zdravilo Ipreziv daje skupaj z drugimi antihipertenzivi, vključno z diuretiki (kot sta klortalidon in hidroklorotiazid) in zaviralci kalcijevih kanalčkov (glejte poglavja 4.3,
English: Ipreziv is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Slovenian: Če boste želeli dojiti, bo zdravnik za vas izbral drugo zdravilo, še zlasti, če je vaš otrok novorojenček ali se je prezgodaj rodil.
English: SPECIAL STORAGE CONDITIONS Store in the original package in order to protect from light and moisture.
Slovenian: Zdravilo Ipreziv shranjujte v originalni ovojnini za zagotovitev zaščite pred svetlobo in vlago.
English: Cartons containing aluminum blisters packs integrated with desiccant.
Slovenian: Škatle z aluminijastimi pretisnimi omoti z integriranim sušilnim sredstvom.
English: Ipreziv blocks this effect so that the blood vessels relax, which helps lower your blood pressure.
Slovenian: krvne žile se sprostijo in to prispeva k znižanju krvnega tlaka.
English: As with other angiotensin II receptor antagonists the combination of lithium and Ipreziv is not recommended (see section 4.5).
Slovenian: Kot pri vseh drugih antagonistih angiotenzina II, kombinacije litija in zdravila Ipreziv ne priporočamo (glejte poglavje 4.5).
English: Nonclinical studies demonstrated that azilsartan did not appear to affect male or female fertility in the rat (see section 5.3).
Slovenian: Podatkov o vplivu zdravila Ipreziv na plodnost pri ljudeh ni. Ne-klinične študije o vplivu azilsartana na moško ali žensko plodnost pri podganah vpliva niso pokazale (glejte poglavje 5.3).
English: Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium.
Slovenian: Angiotenzin II je glavni agens zvišanja tlaka v sistemu renin-angiotenzin in povzroča vazokonstrikcijo, stimulacijo tvorbe in sproščanja aldosterona,
English: Blood creatine phosphokinase increased Blood creatinine increased Blood uric acid increased / Hyperuricemia
Slovenian: Preiskave zvišana koncentracija kreatinfosfokinaze v krvi zvišana koncentracija kreatinina v krvi zvišana koncentracija sečne kisline / hiperurikemija
English: Ipreziv contains an active substance called azilsartan medoxomil and belongs to a class of medicines called angiotensin II receptor antagonists (AIIRAs).
Slovenian: Zdravilo Ipreziv vsebuje zdravilno učinkovino medoksomilazilsartanat in sodi v razred zdravil, ki se imenujejo antagonisti angiotenzina II.
English: Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy Special caution is indicated in patients suffering from aortic or mitral valve stenosis, or hypertrophic obstructive cardiomyopathy (HOCM).
Slovenian: Stenoza aortne in mitralne zaklopke, obstruktivna hipertrofična kardiomiopatija Pri bolnikih s stenozo aortne ali mitralne zaklopke ali s hipertrofično obstruktivno kardiomiopatijo je potrebna posebna previdnost.
English: Azilsartan medoxomil is rapidly hydrolysed to the active moiety azilsartan by esterases in the gastro intestinal tract and/or during drug absorption (see section 5.2).
Slovenian: Medoksomilazilsartanat se hitro hidrolizira v aktivno obliko azilsartan, s pomočjo esteraz v prebavnem traktu in/ali med absorpcijo zdravila (glejte poglavje 5.2).
English: In these two studies, clinically important and most common adverse events included dizziness, headache and dyslipidemia.
Slovenian: V teh dveh študijah so klinično pomembni in najpogostejši neželeni učinki vključevali omotico,