FrancophonIA/ELRC3.0 huggingface dataset:
English: Levodopa/Carbidopa/Entacapone Orion contains three active substances (levodopa, carbidopa and entacapone) in one film-coated tablet.
Croatian: Orion sadrži tri djelatne tvari (levodopu, karbidopu i entakapon) u jednoj filmom obloženoj tableti.
English: Total clearance for levodopa is in the range of 0.55-1.38 l/kg/h and for entacapone is in the range of 0.70 l/kg/h.
Croatian: Ukupni klirens za levodopu nalazi se u rasponu od 0,55-1,38 l/kg/h, dok za entakapon iznosi oko 0,70 l/kg/h.
English: Croscarmellose sodium Magnesium stearate Maize starch Mannitol (E421) Povidone K 30 (E1201)
Croatian: Jezgra tablete: karmelozanatrij, umrežena magnezijev stearat kukuruzni škrob manitol (E421) povidon K 30 (E1201)
English: 75 mg/18.75 mg/200 mg, 100 mg/25 mg/200 mg, 125 mg/31.25 mg/200 mg or
Croatian: 75 mg/18,75 mg/200 mg, 100 mg/25 mg/200 mg, 125 mg/31,25 mg/200 mg ili
English: Levodopa, carbidopa and entacapone together may cause dizziness and symptomatic orthostatism.
Croatian: Levodopa, karbidopa i entakapon mogu zajedno izazvati omaglicu i simptomatsku ortostatsku hipotenziju.
English: - All patients treated with Levodopa/Carbidopa/Entacapone Orion should be monitored carefully for the development of mental changes, depression with suicidal tendencies, and other serious antisocial behaviour.
Croatian: Orionom treba pažljivo pratiti glede razvoja mentalnih promjena, depresije sa suicidalnim tendencijama i drugog teškog antisocijalnog ponašanja.
English: MAO-B inhibitors, or non-selective MAO-inhibitors) - have ever had neuroleptic malignant syndrome (NMS - this is a rare reaction to medicines used to treat severe mental disorders) - have ever had non-traumatic rhabdomyolysis (a rare muscle disorder) - have a severe liver disease.
Croatian: B inhibitora, ili neselektivne MAO-inhibitore), - ako ste ikada imali neuroleptički maligni sindrom (NMS - to je rijetka reakcija na lijekove koji se koriste za liječenje teških duševnih poremećaja), - ako ste bilo kada imali netraumatsku rabdomiolizu (rijetki mišićni poremećaj), - ako imate tešku bolest jetre.
English: Parkinsonism aggravated (e.g. bradykinesia)*, tremor, on and off phenomenon, dystonia, mental impairment (e.g. memory impairment, dementia), somnolence, dizziness*, headache
Croatian: Pogoršanje parkinsonizma (npr. bradikinezija)*, tremor, on-off fenomen, distonija, mentalni poremećaj (npr. poremećaj pamćenja, demencija), somnolencija, omaglica*, glavobolja
English: Levodopa/Carbidopa/Entacapone Orion is not recommended to be used for treatment of extrapyramidal symptoms (e.g. involuntary movements, shaking, muscle rigidity and muscle contractions) caused by other medicines.
Croatian: Orion se ne preporučuje koristiti za liječenje ekstrapiramidnih simptoma (npr. nevoljnih pokreta, tresenja, mišićne ukočenosti i mišićnih kontrakcija) uzrokovanih drugim lijekovima.
English: BOTTLE LABEL AND OUTER CARTON TEXT
Croatian: TEKST NA NALJEPNICI BOČICE I NA VANJSKOM PAKIRANJU
English: - If you are taking Levodopa/Carbidopa/Entacapone Orion 50 mg/12.5 mg/200 mg,
Croatian: - Ako uzimate Levodopa/Carbidopa/Entacapone Orion 50 mg/12,5 mg/200 mg,
English: No particular studies are reported on the pharmacokinetics of levodopa and carbidopa in patients with renal impairment.
Croatian: Nisu objavljena posebna ispitivanja farmakokinetike levodope i karbidope kod bolesnika s oštećenjem bubrega.
English: Common (may affect up to 1 in 10 people) - light-headedness or fainting due to low blood pressure, high blood pressure - worsening of Parkinson`s symptoms, dizziness, drowsiness - vomiting, abdominal pain and discomfort, heartburn, dry mouth, constipation - inability to sleep, hallucinations, confusion, abnormal dreams (including nightmares), tiredness - mental changes - including problems with memory, anxiety and depression (possibly with thoughts of suicide) - heart or artery disease events (e.g. chest pain), irregular heart rate or rhythm - more frequent falling - shortness of breath - increased sweating, rashes - muscle cramps, swelling of legs - blurred vision - anaemia - decreased appetite, decreased weight - headache, joint pain - urinary tract infection
Croatian: Često (može se javiti kod do 1 na 10 osoba) - ošamućenost ili nesvjestica zbog niskog krvnog tlaka, visok krvni tlak - pogoršanje simptoma Parkinsonove bolesti, omaglica, omamljenost - povraćanje, bol i nelagoda u trbuhu, žgaravica, suha usta, zatvor - nesanica, halucinacije, smetenost, poremećeni snovi (uključujući noćne more), umor - duševne promjene - uključujući probleme s pamćenjem, tjeskobu, depresiju (uz moguće samoubilačke misli) - događaji vezani uz bolest srca ili arterija (npr. bol u prsištu), nepravilan puls ili ritam srca - češći padovi - nedostatak zraka - pojačano znojenje, osip - grčevi mišića, oticanje nogu - zamagljen vid - anemija - smanjeni apetit, smanjenje tjelesne težine - glavobolja, bol u zglobovima - upala mokraćnog sustava.
English: Tell your doctor if you or your family/carer notices you are developing addiction-like symptoms leading to craving for large doses of Levodopa/Carbidopa/Entacapone Orion and other medicines used to treat Parkinson's disease.
Croatian: Obavijestite svog liječnika ako Vi ili Vaša obitelj/njegovatelj primijetite da se kod Vas razvijaju simptomi nalik na ovisnost, zbog kojih žudite za velikim dozama lijeka Levodopa/Carbidopa/Entacapone
English: Muscle spasms, arthralgia
Croatian: Spazmi mišića, artralgija
English: Levodopa/Carbidopa/Entacapone Orion with food and drink
Croatian: Levodopa/Carbidopa/Entacapone Orion s hranom i pićem
English: Because the effects of Levodopa/Carbidopa/Entacapone Orion tablets are equivalent with entacapone 200 mg tablet administered concomitantly with the commercially available standard release carbidopa/levodopa preparations in corresponding doses these results are applicable to describe the effects of Levodopa/Carbidopa/Entacapone Orion as well.
Croatian: Orion tableta ekvivalentni s entakapon 200 mg tabletom primijenjenom istodobno s komercijalno dostupnim preparatima karbidope/levodope sa standardnim oslobađanjem u odgovarajućim dozama, ovi su rezultati isto tako primjenjivi za opis učinaka Levodopa/Carbidopa/Entacapone Oriona.
English: If this happens, a general medical evaluation including liver function should be considered - feel the need to stop using Levodopa/Carbidopa/Entacapone Orion, see section 'If you stop taking Levodopa/Carbidopa/Entacapone Orion'.
Croatian: Ako se to dogodi, mora se razmotriti opća medicinska procjena uključujući procjenu jetrene funkcije. - osjetite potrebu da prestanete uzimati Levodopa/Carbidopa/Entacapone
English: Yellow iron oxide (E172)
Croatian: željezov oksid, crveni (E172) saharoza titanijev dioksid (E171) željezov oksid, žuti (E172)
English: - Levodopa/Carbidopa/Entacapone Orion therapy should be administered cautiously to patients with ischemic heart disease, severe cardiovascular or pulmonary disease, bronchial asthma, renal or endocrine disease, history of peptic ulcer disease or history of convulsions.
Croatian: Orionom treba provoditi uz oprez u bolesnika s ishemijskom bolešću srca, teškom kardiovaskularnom ili plućnom bolešću, bronhijalnom astmom, bubrežnom ili endokrinom bolešću, kao i u bolesnika s peptičkim ulkusom ili konvulzijama u anamnezi.
English: The evidence of the therapeutic effects of Levodopa/Carbidopa/Entacapone Orion is based on two phase III double-blind studies, in which 376 Parkinson's disease patients with end-of-dose motor fluctuations received either entacapone or placebo with each levodopa/DDC inhibitor dose.
Croatian: Oriona temelji se na dva dvostruko slijepa klinička ispitivanja faze III, u kojima je 376 bolesnika s Parkinsonovom bolešću i motoričkim fluktuacijama na kraju intervala doziranja, uz svaku dozu levodope/DDC-inhibitora primalo ili entakapon ili placebo.
English: Chest pain, peripheral oedema, fall, gait disturbance, asthenia, fatigue
Croatian: Bol u prsištu, periferni edem, pad, poremećaj hoda, astenija, umor Manje često: Malaksalost
English: Rare:
Croatian: (rijetko).
English: - Coadministration with a selective MAO-A inhibitor and a selective MAO-B inhibitor (see section 4.5).
Croatian: - Istodobna primjena sa selektivnim MAO-A inhibitorom i selektivnim MAO-B inhibitorom
English: - If you are taking Levodopa/Carbidopa/Entacapone Orion 175 mg/43.75 mg/200 mg tablets, do not take more than 8 tablets of this strength per day.
Croatian: - Ako uzimate Levodopa/Carbidopa/Entacapone Orion 175 mg/43,75 mg/200 mg tablete, nemojte uzeti više od 8 tableta dnevno.
English: Do not take Levodopa/Carbidopa/Entacapone Orion if you are taking certain medicines for treating depression (combinations of selective MAO-A and MAO-B inhibitors, or non-selective MAO inhibitors).
Croatian: Orion ako uzimate određene lijekove za liječenje depresije (kombinaciju selektivnih MAO-A i MAO-B inhibitora, ili neselektivne MAO inhibitore).
English: Pack sizes of 50/12.5/200 mg, 100/25/200 mg and 150/37.5/200 mg: 10, 30, 100, 130, 175 and 250 tablets.
Croatian: Veličine pakiranja za 50/12,5/200 mg, 100/25/200 mg i 150/37,5/200 mg: 10, 30, 100, 130, 175 i 250 tableta.
English: Orion Pharma (Ireland) Ltd. c/o Allphar Services Ltd. Tel: +353 1 428 7777
Croatian: Orion Pharma (Ireland) Ltd. c/o Allphar Services Ltd.
English: Antihypertensives: Symptomatic postural hypotension may occur when levodopa is added to the treatment of patients already receiving antihypertensives.
Croatian: Antihipertenzivi: kada se levodopa dodaje bolesnicima koji već uzimaju antihipertenzive može se javiti simptomatska posturalna hipotenzija.
English: Constipation*, vomiting*, dyspepsia, abdominal pain and discomfort*, dry mouth*
Croatian: Konstipacija*, povraćanje*, dispepsija, bol i nelagoda u abdomenu*, suha usta* Manje često: Kolitis*, disfagija
English: Grounds for the variation to the terms of the Marketing Authorisations
Croatian: Razlozi za izmjenu uvjeta odobrenja za stavljanje lijeka u promet
English: Discolourations other than urine (e.g. skin, nail, hair, sweat)*
Croatian: Manje često: Diskoloracije nevezane uz mokraću (npr. koža, nokti, kosa, znoj)* Rijetko:
English: As part of this PSUSA procedure, update of the levodopa/carbidopa/entacapone SmPCs with identical changes regarding dopamine dysregulation syndrome as agreed previously by the CMDh in the PSUSA process for levodopa/carbidopa containing products is considered warranted.
Croatian: Smatra se opravdanim da se u sklopu ovog PSUSA postupka ažuriraju sažeci opisa svojstava lijeka za levodopu/karbidopu/entakapon s identičnim promjenama vezano uz sindrom poremećene regulacije dopamina, kako je dogovoreno s CMDh-om u prethodnom PSUSA postupku za lijekove koji sadrže levodopu/karbidopu.
English: A syndrome resembling the neuroleptic malignant syndrome including muscular rigidity, elevated body temperature, mental changes and increased serum creatine phosphokinase has been reported with the abrupt withdrawal of antiparkinsonian agents.
Croatian: Prilikom naglog prekida uzimanja antiparkinsonika zabilježen je sindrom sličan neuroleptičkom malignom sindromu uključujući mišićnu rigidnost, povišenu tjelesnu temperaturu, mentalne promjene i povišenu kreatin fosfokinazu u serumu.
English: Serious hepatitis with mainly cholestatic features, rhabdomyolysis and neuroleptic malignant syndrome may occur with Levodopa/Carbidopa/Entacapone Orion although no cases have been identified from the clinical trial data.
Croatian: Ozbiljni hepatitis s uglavnom kolestatskim obilježjima, rabdomioliza i neuroleptički maligni sindrom mogu se javiti uz Levodopa/Carbidopa/Entacapone
English: - If you are taking Levodopa/Carbidopa/Entacapone Orion 200 mg/50 mg/200 mg, do not take more than 7 tablets of this strength per day.
Croatian: - Ako uzimate Levodopa/Carbidopa/Entacapone Orion 200 mg/50 mg/200 mg tablete, nemojte uzeti više od 7 tableta dnevno.
English: Antidepressants: Rarely, reactions including hypertension and dyskinesia have been reported with the concomitant use of tricyclic antidepressants and levodopa/carbidopa.
Croatian: Antidepresivi: s istodobnom primjenom tricikličkih antidepresiva i levodope/karbidope rijetko su zabilježene reakcije koje uključuju hipertenziju i diskineziju.
English: If therapy has to be stopped temporarily, Levodopa/Carbidopa/Entacapone Orion may be restarted as soon as oral medicinal products can be taken at the same daily dose as before.
Croatian: Oriona može se ponovno započeti čim se mogu uzimati oralni lijekovi uz isto dnevno doziranje kao i prije.
English: If you suddenly stop taking Levodopa/Carbidopa/Entacapone Orion and other antiparkinsonian medicines it may result in unwanted side effects.
Croatian: Naglo ukidanje Levodopa/Carbidopa/Entacapone Oriona i drugih antiparkinsonika može rezultirati neželjenim nuspojavama.
English: Talk to your doctor or pharmacist before taking Levodopa/Carbidopa/Entacapone Orion if you have or have ever had: - a heart attack or any other diseases of the heart including cardiac arrhythmias, or of the blood vessels - asthma or any other disease of the lungs
Croatian: Orion ako imate ili ste ikada imali: - srčani udar ili bilo koju drugu bolest srca uključujući srčane aritmije, ili bolest krvnih žila - astmu ili bilo koju drugu bolest pluća,
English: - The other ingredients in the tablet core are croscarmellose sodium, magnesium stearate, maize starch, mannitol (E421) and povidone (E1201).
Croatian: - Drugi sastojci u jezgri tablete su umrežena karmelozanatrij, magnezijev stearat, kukuruzni škrob, manitol (E421) i povidon (E1201).
English: Therefore Levodopa/Carbidopa/Entacapone Orion should be given cautiously to patients who are taking other medicinal products which may cause orthostatic hypotension.
Croatian: Orion treba oprezno davati bolesnicima koji uzimaju druge lijekove koji mogu prouzročiti ortostatsku hipotenziju.
English: For example, a patient taking one tablet of 50 mg/12.5 mg of levodopa/carbidopa with one tablet of entacapone 200 mg four times daily can take one 50 mg/12.5 mg/200 mg Levodopa/Carbidopa/Entacapone Orion tablet four times daily in place of their usual levodopa/carbidopa and entacapone doses.
Croatian: Na primjer, bolesnik koji uzima jednu tabletu od 50 mg/12,5 mg levodope/karbidope s jednom tabletom entakapona 200 mg četiri puta dnevno može uzeti jednu Levodopa/Carbidopa/Entacapone
English: What Levodopa/Carbidopa/Entacapone Orion is and what it is used for What you need to know before you take Levodopa/Carbidopa/Entacapone Orion How to take Levodopa/Carbidopa/Entacapone Orion Possible side effects
Croatian: Orion i za što se koristi Što morate znati prije nego počnete uzimati Levodopa/Carbidopa/Entacapone Orion Kako uzimati Levodopa/Carbidopa/Entacapone Orion Moguće nuspojave
English: c. When initiating Levodopa/Carbidopa/Entacapone Orion in patients currently treated with entacapone and levodopa/benserazide in a standard release formulation, the dosing of levodopa/benserazide should be discontinued in the previous night, and Levodopa/Carbidopa/Entacapone Orion should be started in the next morning.
Croatian: Orion uvodi bolesnicima koji su trenutno liječeni entakaponom i formulacijom sa standardnim oslobađanjem levodope/benzerazida, potrebno je prekinuti doziranje levodope/benzerazida noć prije i započeti sa Levodopa/Carbidopa/Entacapone
English: Urticaria*
Croatian: Urtikarija*
English: Women should not breast-feed during treatment with Levodopa/Carbidopa/Entacapone Orion.
Croatian: Žene ne smiju dojiti tijekom liječenja Levodopa/Carbidopa/Entacapone Orionom.
English: Label 10 tablets 30 tablets 100 tablets 130 tablets 175 tablets
Croatian: Naljepnica 10 tableta 30 tableta 100 tableta 130 tableta 175 tableta
English: Levodopa/Carbidopa/Entacapone Orion is indicated for the treatment of adult patients with Parkinson's disease and end-of-dose motor fluctuations not stabilised on levodopa/dopa decarboxylase (DDC) inhibitor treatment.
Croatian: Orion je indiciran za liječenje odraslih bolesnika s Parkinsonovom bolešću, kao i za liječenje motoričkih fluktuacija na kraju intervala doziranja koje nisu stabilizirane primjenom levodope/inhibitora dopa dekarboksilaze (DDC).
English: Pack sizes of 75/18.75/200 mg, 125/31.25/200 mg, 175/43.75/200 mg and 200/50/200 mg: 10, 30, 100, 130 and 175 tablets.
Croatian: Veličine pakiranja za 75/18,75/200 mg, 125/31,25/200 mg, 175/43,75/200 mg i 200/50/200 mg: 10, 30, 100, 130 i 175 tableta.
English: 5 How to store Levodopa/Carbidopa/Entacapone Orion Contents of the pack and other information
Croatian: Kako čuvati Levodopa/Carbidopa/Entacapone Orion Sadržaj pakiranja i druge informacije
English: Elderly: No dose adjustment of Levodopa/Carbidopa/Entacapone Orion is required for elderly.
Croatian: Starije osobe: starijim osobama nije potrebno prilagođavati dozu Levodopa/Carbidopa/Entacapone Oriona.
English: Label 10 tablets 30 tablets 100 tablets 130 tablets 175 tablets 250 tablets
Croatian: Naljepnica 10 tableta 30 tableta 100 tableta 130 tableta 175 tableta 250 tableta
English: The daily dose should be preferably optimised using one of the seven available tablet strengths (50 mg/12.5 mg/200 mg, 75 mg/18.75 mg/200 mg, 100 mg/25 mg/200 mg, 125 mg/31.25 mg/200 mg, 150 mg/37.5 mg/200 mg, 175 mg/43.75 mg/200 mg or 200 mg/50 mg/200 mg levodopa/carbidopa/entacapone).
Croatian: Dnevna doza treba se optimalno postići korištenjem jedne od sedam jačina tableta koje su na raspolaganju (50 mg/12,5 mg/200 mg, 75 mg/18,75 mg/200 mg, 100 mg/25 mg/200 mg, 125 mg/31,25 mg/200 mg, 150 mg/37,5 mg/200 mg, 175 mg/43,75 mg/200 mg ili 200 mg/50 mg/200 mg levodope/karbidope/entakapona).
English: - Dopamine Dysregulation Syndrome (DDS) is an addictive disorder resulting in excessive use of the product seen in some patients treated with carbidopa/levodopa.
Croatian: Dopamine Dysregulation Syndrome, DDS) je poremećaj s ovisnosničkim obrascem ponašanja koji dovodi do prekomjerne primjene lijeka, a primijećen je u nekih bolesnika liječenih karbidopom/levodopom.
English: What you need to know before you take Levodopa/Carbidopa/Entacapone Orion
Croatian: Što morate znati prije nego počnete uzimati Levodopa/Carbidopa/Entacapone Orion
English: The following adverse reactions, listed in Table 1, have been accumulated both from a pooled data of eleven double-blind clinical trials consisting of 3230 patients (1810 treated with Levodopa/Carbidopa/Entacapone Orion or entacapone combined with levodopa/DDC inhibitor, and 1420 treated with placebo combined with levodopa/DDC inhibitor or cabergoline combined with levodopa/ DDC inhibitor), and from the post-marketing data since the introduction of entacapone into the market for the combination use of entacapone with levodopa/DDC inhibitor.
Croatian: Orionom ili entakaponom u kombinaciji s levodopom/DDCinhibitorom, i 1420 liječenih placebom u kombinaciji s levodopom/DDC-inhibitorom ili kabergolinom u kombinaciji s levodopom/DDC-inhibitorom) i iz podataka dobivenih nakon stavljanja entakapona na tržište za njegovu kombiniranu primjenu s levodopom/DDC-inhibitorom.
English: When considered necessary, the replacement of Levodopa/Carbidopa/Entacapone Orion with levodopa and DDC inhibitor without entacapone or other dopaminergic treatment should proceed slowly and an increase in levodopa dose may be necessary.
Croatian: Oriona levodopom i DDC-inhibitorom bez entakapona ili drugim dopaminergičkim liječenjem treba se odvijati polako te može biti potrebno povećanje doziranja levodope.
English: - Rhabdomyolysis secondary to severe dyskinesias or neuroleptic malignant syndrome (NMS) has been observed rarely in patients with Parkinson's disease.
Croatian: - U bolesnika s Parkinsonovom bolešću rijetko je opažena rabdomioliza uslijed teških diskinezija ili neuroleptičkog malignog sindroma (NMS).
English: Dopamine Dysregulation Syndrome (DDS) is an addictive disorder seen in some patients treated with carbidopa/levodopa.
Croatian: Sindrom poremećene regulacije dopamina je poremećaj s ovisničkim obrascem ponašanja primijećen u nekih bolesnika liječenih karbidopom/levodopom.
English: Usually Levodopa/Carbidopa/Entacapone Orion is to be used in patients who are currently treated with corresponding doses of standard release levodopa/DDC inhibitor and entacapone.
Croatian: Orion obično treba koristiti u bolesnika koji se već liječe odgovarajućim dozama levodope/DDC-inhibitora sa standardnim oslobađanjem i entakapona.
English: At the initiation, Levodopa/Carbidopa/Entacapone Orion should be adjusted to correspond as closely as possible to the total daily dose of levodopa currently used.
Croatian: Oriona da bi ona bila što je moguće bliža ukupnoj dnevnoj dozi levodope koja se trenutno koristi.
English: Uncommon (may affect up to 1 in 100 people) - heart attack - bleeding in the gut - changes in the blood cell count which may result in bleeding, abnormal liver function tests - convulsions - feeling agitated - psychotic symptoms - colitis (inflammation of the colon) - discolourations other than urine (e.g. skin, nail, hair, sweat) - swallowing difficulties - inability to urinate
Croatian: Manje često (može se javiti kod do 1 na 100 osoba) - srčani udar - krvarenje u crijevima - promjene broja krvnih stanica što može dovesti do krvarenja, poremećeni nalazi pretrage jetrene funkcije - konvulzije - osjećaj uznemirenosti - psihotički simptomi - kolitis (upala debelog crijeva) - promjene boje nevezane uz mokraću (npr. koža, nokti, kosa, znoj) - teškoće s gutanjem, nemogućnost mokrenja.
English: Film-coating of 50/12.5/200 mg, 100/25/200 mg and 150/37.5/200 mg: Glycerol (85 per cent) (E422)
Croatian: Film ovojnica za 50/12,5/200 mg, 100/25/200 mg i 150/37,5/200 mg: glicerol (85-postotni) (E422) hipromeloza magnezijev stearat polisorbat 80
English: However, a direct switch from levodopa/DDC inhibitor to Levodopa/Carbidopa/Entacapone Orion is not recommended for patients who have dyskinesias or whose daily levodopa dose is above 800 mg.
Croatian: Orion ne preporučuje se za bolesnike koji imaju diskinezije ili čija je dnevna doza levodope iznad 800 mg.
English: 10 film-coated tablets 30 film-coated tablets 100 film-coated tablets 130 film-coated tablets 175 film-coated tablets 250 film-coated tablets
Croatian: 10 filmom obloženih tableta 30 filmom obloženih tableta 100 filmom obloženih tableta 130 filmom obloženih tableta 175 filmom obloženih tableta 250 filmom obloženih tableta
English: b. When initiating Levodopa/Carbidopa/Entacapone Orion therapy for patients currently treated with entacapone and levodopa/carbidopa in doses not equal to Levodopa/Carbidopa/Entacapone Orion tablets (50 mg/12.5 mg/200 mg or 75 mg/18.75 mg/200 mg or 100 mg/25 mg/200 mg or 125 mg/31.25 mg/200 mg or 150 mg/37.5 mg/200 mg or 175 mg/43.75 mg/200 mg or 200 mg/50 mg/200 mg), Levodopa/Carbidopa/Entacapone Orion dosing should be carefully titrated for optimal clinical response.
Croatian: Orionom uvodi bolesnicima koji su trenutno liječeni entakaponom i levodopom/karbidopom u dozama koje ne odgovaraju Levodopa/Carbidopa/Entacapone Orion tabletama (50 mg/12,5 mg/200 mg ili 75 mg/18,75 mg/200 mg ili 100 mg/25 mg/200 mg ili 125 mg/31,25 mg/200 mg ili 150 mg/37,5 mg/200 mg ili 175 mg/43,75 mg/200 mg ili 200 mg/50 mg/200 mg), doziranje Levodopa/Carbidopa/Entacapone
English: No particular studies on the pharmacokinetics of carbidopa and levodopa in patients with hepatic impairment are reported, however, it is advised that Levodopa/Carbidopa/Entacapone Orion should be administered cautiously to patients with mild or moderate hepatic impairment.
Croatian: Nisu objavljena posebna ispitivanja farmakokinetike karbidope i levodope kod bolesnika s oštećenjem jetre, međutim, savjetuje se oprezna primjena Levodopa/Carbidopa/Entacapone
English: Other medicines and Levodopa/Carbidopa/Entacapone Orion
Croatian: Drugi lijekovi i Levodopa/Carbidopa/Entacapone Orion
English: - Patients with chronic wide-angle glaucoma may be treated with Levodopa/Carbidopa/Entacapone Orion with caution, provided the intra-ocular pressure is well controlled and the patient is monitored carefully for changes in intra-ocular pressure.
Croatian: Orionom pod uvjetom da je intraokularni tlak dobro kontroliran i da se bolesnike pažljivo prati zbog promjena intraokularnog tlaka.