FrancophonIA/ELRC3.0 huggingface dataset:
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) concluded that there is a need to harmonise the prescribing information for Novantrone in the European Union (EU).
Croatian: Odbor za lijekove za humanu uporabu (CHMP) pri Agenciji zaključio je da postoji potreba za usklađivanjem informacija o propisivanju lijeka Novantrone u Europskoj uniji (EU).
English: The CHMP agreed that Novantrone can be used for the treatment of the following conditions:
Croatian: CHMP se složio da se lijek Novantrone može upotrebljavati za liječenje sljedećih bolesti:
English: • Relief of pain in patients with advanced prostate cancer;
Croatian: • ublažavanja boli u bolesnika s uznapredovalim rakom prostate;
English: Novantrone is a medicine that is used in the treatment of cancers including breast cancer, non-Hodgkin's lymphoma (a cancer of the lymphatic system, which is part of the immune system) and certain types of blood cancer, as well as pain caused by prostate cancer.
Croatian: Novantrone je lijek koji se primjenjuje u liječenju raka, uključujući raka dojke, ne-Hodgkinova limfoma (vrsta raka limfnog sustava, dijela imunosnog sustava) i određenih vrsta raka krvi, kao i boli uzrokovane rakom prostate.
English: The CHMP also harmonised the recommendations on how to use Novantrone for the different indications.
Croatian: CHMP je također uskladio preporuke o načinu uporabe lijeka Novantrone za različite indikacije.
English: The CHMP also agreed that Novantrone should no longer be approved for the treatment of acute lymphocytic leukaemia (a cancer of a different type of white blood cells) and liver cancer.
Croatian: CHMP se također složio da lijek Novantrone više ne bi trebao biti odobren za liječenje akutne limfocitne leukemije (raka druge vrste bijelih krvnih stanica) i raka jetre.
English: On 28 April 2016, the European Medicines Agency completed a review of Novantrone.
Croatian: Europska agencija za lijekove dovršila je ocjenjivanje lijeka Novantrone 28. travnja 2016.
English: On 1 October 2014, the European Commission referred the matter to the CHMP in order to harmonise the marketing authorisations for Novantrone in the EU.
Croatian: Europska je komisija 1. listopada 2014. uputila predmet CHMP-u radi usklađivanja odobrenja za stavljanje u promet lijeka Novantrone u EU-u.
English: The CHMP, in the light of the data submitted and the scientific discussion within the Committee, considered that the SmPCs, labelling and package leaflets should be harmonised across the EU.
Croatian: U svjetlu dostavljenih podataka i znanstvene rasprave u okviru Odbora, CHMP smatra da se sažetci opisa svojstava lijeka, naljepnice i upute o lijeku trebaju uskladiti na razini EU-a.
English: Mitoxantrone, the active substance in Novantrone, passes into breast milk and has been detected in breast milk for up to one month after the medicine was discontinued.
Croatian: Djelatna tvar u lijeku Novantrone, mitoksantron, izlučuje se u majčino mlijeko te je pronađen u njemu do mjesec dana nakon prestanka primjene lijeka.
English: Novantrone contains the active substance mitoxantrone and it is available as a concentrate to be made into a solution for infusion (drip) into a vein.
Croatian: Lijek Novantrone sadrži djelatnu tvar mitoksantron te je dostupan kao koncentrat od kojeg se priprema otopina za intravensku infuziju (drip).
English: This has led to divergences across Member States in the medicine's authorised uses, as seen in the differences in the summaries of product characteristics (SmPCs), labelling and package leaflets.
Croatian: To je dovelo do odstupanja među državama članicama u pogledu načina odobrene primjene lijeka, što je vidljivo u razlikama među sažecima opisa svojstava lijeka, naljepnicama i uputama o lijeku.
English: • ‘Blast crisis' in chronic myeloid leukaemia (the final, rapidly progressive stage of another type of cancer of white blood cells);
Croatian: • „blastnih kriza” u bolesnika s kroničnom mijeloičnom leukemijom (završnog stadija druge vrste raka bijelih krvnih stanica koji brzo napreduje);
English: Novantrone should only be given by infusion into a vein.
Croatian: Lijek Novantrone trebao bi se primjenjivati isključivo intravenskom infuzijom.
English: • Acute myeloid leukaemia (cancer of a type of white blood cell called myeloid cells);
Croatian: • akutne mijeloične leukemije (raka mijeloidnih stanica, vrste bijelih krvnih stanica);
English: Therefore, to avoid potential serious side effects in breastfed infants, breastfeeding must be discontinued before starting treatment with Novantrone.
Croatian: Stoga je potrebno prekinuti dojenje prije početka liječenja lijekom Novantrone kako bi se izbjegle moguće ozbiljne nuspojave u dojenčadi.
English: Novantrone was identified as needing harmonisation by the Co-ordination Group for Mutual Recognition and Decentralised Procedures - Human (CMDh).
Croatian: Koordinacijska skupina za postupak međusobnog priznavanja i decentralizirani postupak za humane lijekove (CMDh) utvrdila je da je u pogledu lijeka Novantrone potrebno provesti usklađivanje.
English: MA (EU) number
Croatian: Broj nositelja odobrenja (MA) (EU)
English: Pack size
Croatian: Pakiranje
English: (Invented) name
Croatian: Naziv
English: A possible risk after short term treatment cannot be excluded.
Croatian: Ne može se isključiti mogući rizik ni nakon kratkotrajnog liječenja.
English: One tablet should be taken once daily.
Croatian: Jedanput na dan treba uzeti jednu tabletu.
English: If necessary your doctor may tell you to take a different dose.
Croatian: Ako bude potrebno, liječnik će Vam reći da uzimate drugačiju dozu.
English: Nederland Focus Care Pharmaceuticals B.V.
Croatian: Focus Care Pharmaceuticals B.V.
English: Frequencies are defined as:
Croatian: Učestalost je navedena kao:
English: If ALT levels remain > 3 times the upper limit of normal, therapy should be discontinued.
Croatian: Ako razine ALT ostanu povišene > 3 puta iznad gornje granice normale, terapiju treba prekinuti.
English: 14 tablets 28 tablets 30 tablets 56 tablets 60 tablets 90 tablets 98 tablets
Croatian: 14 tableta 28 tableta 30 tableta 56 tableta 60 tableta 90 tableta 98 tableta
English: Do not take Pioglitazone Krka: - if you are allergic to pioglitazone or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati Pioglitazone Krka: - ako ste alergični na pioglitazon ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: Blister packs (OPA/Al/PVC-Al foil): 14, 28, 30, 56, 60, 90 and 98 tablets in a box.
Croatian: Blister pakiranja (OPA/Al/PVC-Al folija): 14, 28, 30, 56, 60, 90 i 98 tableta, u kutiji.
English: Proportional increases of the plasma concentration were observed for doses from 2 - 60 mg.
Croatian: Proporcionalno povišenje koncentracije u plazmi bilo je primijećeno kod doza od 2 mg do 60 mg.
English: What Pioglitazone Krka is and what it is used for
Croatian: Što je Pioglitazone Krka i za što se koristi
English: Pioglitazone should be discontinued if any deterioration in cardiac status occurs.
Croatian: Pioglitazon treba prekinuti ako nastupi pogoršanje srčanog statusa.
English: The Prescriber Guide should highlight the following: - Patient selection criteria including that Pioglitazone should not be used as first line therapy and emphasising the need for regular review of treatment benefit.
Croatian: Vodič za propisivanje lijeka treba istaknuti sljedeće: - Kriterije za odabir bolesnika uključujući to da se Pioglitazone ne smije primjenjivati kao prva linija terapije i naglašavajući potrebu za redovitim provjerama koristi od liječenja.
English: Oedema was reported in 6 - 9% of patients treated with pioglitazone over one year in controlled clinical trials.
Croatian: Edem je bio zabilježen u 6-9% bolesnika liječenih pioglitazonom tijekom jedne godine u kontroliranim kliničkim ispitivanjima.
English: The tablets are available in boxes of 14, 28, 30, 56, 60, 90 and 98 tablets in blisters.
Croatian: Tablete su dostupne u kutijama s 14, 28, 30, 56, 60, 90 i 98 tableta u blisterima.
English: Management Symptomatic and general supportive measures should be taken in case of overdose.
Croatian: U slučaju predoziranja treba primijeniti simptomatske i opće suportivne mjere.
English: Close monitoring of glycaemic control should be considered (see section 4.4).
Croatian: Potrebno je razmotriti pozorno praćenje kontrole glikemije (vidjeti dio 4.4).
English: very common (may affect more than 1 in 10 people) - decreased blood sugar (hypoglycaemia)
Croatian: vrlo često (mogu se javiti u više od 1 na 10 osoba) - snižen šećer u krvi (hipoglikemija)
English: Therapy with pioglitazone should not be initiated in patients with increased baseline liver enzyme levels (ALT > 2.5 times the upper limit of normal) or with any other evidence of liver disease.
Croatian: Terapija pioglitazonom ne smije se započeti u bolesnika s povišenim početnim razinama jetrenih enzima (ALT > 2,5 puta iznad gornje granice normale) ili nekim drugim dokazom bolesti jetre.
English: Prior to distribution of the prescriber guide in each Member State, the MAH must agree the content and format of the educational material, together with a communication plan, with the national competent authority.
Croatian: Članici, nositelj odobrenja mora dogovoriti sadržaj i oblik edukacijskog materijala, zajedno s komunikacijskim planom, s nacionalnim nadležnim tijelom.
English: - if you have or ever had bladder cancer.
Croatian: - ako imate ili ste imali karcinom mokraćnog mjehura.
English: Before you start taking Pioglitazone Krka you will have a blood sample taken to check your liver function.
Croatian: Prije nego što počnete uzimati Pioglitazone Krka uzet će Vam se uzorak krvi da bi se provjerila funkcija jetre.
English: Your doctor will check whether Pioglitazone Krka is working 3 to 6 months after you start taking it.
Croatian: Liječnik će provjeriti djelovanje lijeka Pioglitazone Krka 3 do 6 mjeseci nakon što ga počnete uzimati.
English: Pioglitazone Krka helps control the level of sugar in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.
Croatian: Pioglitazone Krka pridonosi kontroli razine šećera u krvi kad imate šećernu bolest tipa 2, tako što pomaže Vašem tijelu da bolje iskoristi inzulin koji stvara.
English: In animals, only a small amount of unchanged pioglitazone can be detected in either urine or faeces.
Croatian: U životinja se samo mala količina neizmijenjenog pioglitazona može otkriti u mokraći ili fecesu.
English: Available epidemiological data also suggest a small increased risk of bladder cancer in diabetic patients treated with pioglitazone in particular in patients treated for the longest durations and with the highest cumulative doses.
Croatian: Dostupni epidemiološki podaci također ukazuju na malo povećan rizik od karcinoma mokraćnog mjehura u bolesnika sa šećernom bolešću liječenih pioglitazonom, osobito u najdulje liječenih bolesnika u kojih su kumulativne doze bile najviše.
English: The rate of deterioration of HbA1c during the second year was less with pioglitazone than with gliclazide.
Croatian: Stopa pogoršanja HbA1c tijekom druge godine bila je manja uz pioglitazon nego uz gliklazid.
English: If you have the impression that the effect of Pioglitazone Krka is too weak, talk to your doctor.
Croatian: Ako imate dojam da je učinak lijeka Pioglitazone Krka preslab, razgovarajte o tome sa svojim liječnikom.
English: If you take Pioglitazone Krka with other medicines for diabetes, it is more likely that your blood sugar could fall below the normal level (hypoglycaemia).
Croatian: Ako uzimate Pioglitazone Krka s drugim lijekovima za šećernu bolest, veća je vjerojatnost da Vam šećer u krvi padne ispod normalne razine (hipoglikemija).
English: What Pioglitazone Krka is and what it is used for What you need to know before you take Pioglitazone Krka How to take Pioglitazone Krka Possible side effects
Croatian: Što je Pioglitazone Krka i za što se koristi Što morate znati prije nego počnete uzimati Pioglitazone Krka Kako uzimati Pioglitazone Krka Moguće nuspojave
English: Pharmacotherapeutic group: Drugs used in diabetes, blood glucose lowering drugs, excl. insulins; ATC code: A10BG03.
Croatian: Farmakoterapijska skupina: Pripravci za liječenje šećerne bolesti; Lijekovi za snižavanje glukoze u krvi, osim inzulina; ATK oznaka: A10BG03.
English: Pioglitazone has no or negligible influence on the ability to drive and use machines.
Croatian: Pioglitazon ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: The risk of fractures should be considered in the long term care of women treated with pioglitazone.
Croatian: Rizik od prijeloma treba uzeti u obzir kod dugotrajnog liječenja žena pioglitazonom.
English: This is the diabetes that usually develops in adulthood.
Croatian: Ovaj tip šećerna bolest obično se razvija u odrasloj dobi.
English: Pioglitazone Krka with food and drink You may take your tablets with or without food.
Croatian: Pioglitazone Krka s hranom i pićem Tablete možete uzimati s hranom ili bez nje.
English: Environmental Risk Assessment (ERA): no environmental impact is anticipated from the clinical use of pioglitazone.
Croatian: Procjena rizika za okoliš (ERA): ne očekuje se utjecaj kliničke primjene pioglitazona na okoliš.
English: Cases of bladder cancer were reported more frequently in a meta-analysis of controlled clinical trials with pioglitazone (19 cases from 12506 patients, 0.15%) than in control groups (7 cases from 10212 patients, 0.07%) HR=2.64 (95% CI 1.11-6.31, P=0.029).
Croatian: U metaanalizi kontroliranih kliničkih ispitivanja češće su zabilježeni slučajevi karcinoma mokraćnog mjehura u skupinama koje su primale pioglitazon (19 slučajeva na 12 506 bolesnika, 0,15%) nego u kontrolnim skupinama (7 slučajeva na 10 212 bolesnika, 0,07%) HR=2,64 (95% CI 1,11-6,31, P=0,029).
English: If you stop using Pioglitazone Krka tablets, your blood sugar may go up.
Croatian: Ako prestanete uzimati Pioglitazone Krka, šećer u krvi Vam se može povisiti.
English: It is an anti-diabetic medicine used to treat type 2 (noninsulin dependent) diabetes mellitus, when metformin is not suitable or has failed to work adequately.
Croatian: To je antidijabetički lijek koji se primjenjuje za liječenje šećerne bolesti tipa 2 (neovisne o inzulinu), kad metformin nije pogodan ili nije imao odgovarajuće djelovanje.
English: - Caution in use in the elderly in light of age related risks (in particular bladder cancer, fractures and heart failure).
Croatian: - Oprez kod primjene u starijih s obzirom na rizike povezane s dobi (osobito karcinom mokraćnog mjehura, prijelome i zatajenje srca).
English: - The physician educational pack should contain: The Summary of Product Characteristics, package leaflet, and a Prescriber Guide.
Croatian: - Edukacijski paket za liječnike treba sadržavati: Sažetak opisa svojstava lijeka, Uputu o lijeku i Vodič za propisivanje lijeka.
English: When Pioglitazone Krka is taken in combination with other medicines used to treat diabetes (such as insulin, chlorpropamide, glibenclamide, gliclazide, tolbutamide) your doctor will tell you whether you need to take a smaller dose of your medicines.
Croatian: Kad se Pioglitazone Krka uzima zajedno s drugim lijekovima za liječenje šećerne bolesti (kao što su inzulin, klorpropamid, glibenklamid, gliklazid, tolbutamid) liječnik će Vam reći trebate li te lijekove uzimati u manjim dozama.
English: Pioglitazone Krka may be used on its own in patients who are unable to take metformin, and where treatment with diet and exercise has failed to control blood sugar or may be added to other therapies (such as sulphonylurea or insulin) which have failed to provide sufficient control of blood sugar.
Croatian: Pioglitazone Krka se može primjenjivati sam u bolesnika koji ne mogu uzimati metformin, a kod kojih se liječenjem dijetom i tjelovježbom nije uspjela postići kontrola šećera u krvi, ili se može dodati drugim lijekovima (kao što su sulfonilureja ili inzulin) koji nisu uspjeli osigurati dostatnu kontrolu šećera u krvi.
English: Immune System Disorders Hypersensitivity and allergic reactions not known not known not known not known not known
Croatian: Poremećaji imunološkog sustava preosjetljivost i alergijske reakcije nepoznato nepoznato nepoznato nepoznato nepoznato
English: - This educational pack is aimed at strengthening awareness of important identified risks of bladder cancer and heart failure and the overall recommendations intended to optimise the benefit-risk margin at the patient level.
Croatian: - Svrha ovog edukacijskog paketa jest povisiti svijest o važnosti utvrđenih rizika od karcinoma mokraćnog mjehura i zatajenja srca te opće preporuke namijenjene optimizaciji raspona koristi u odnosu na rizik na razini bolesnika.
English: A 24month mechanistic study in male rats demonstrated that administration of pioglitazone resulted in an increased incidence of hyperplastic changes in the bladder.
Croatian: Ispitivanjem u trajanju od 24 mjeseca u mužjaka štakora pokazalo se da primjena pioglitazona rezultira povećanom incidencijom hiperplastičkih promjena u mokraćnom mjehuru.
English: If you are following a diabetic diet, you should continue with this while you are taking Pioglitazone Krka.
Croatian: Ako se pridržavate dijabetičke dijete, trebate nastaviti s dijetom dok uzimate Pioglitazone Krka.
English: Pioglitazone Krka contains pioglitazone.
Croatian: Pioglitazone Krka sadrži pioglitazon.
English: What you need to know before you take Pioglitazone Krka
Croatian: Što morate znati prije nego počnete uzimati Pioglitazone Krka
English: - The risk of heart failure and relevant risk minimisation advice.
Croatian: - Rizik od zatajenja srca i odgovarajuće savjete o smanjivanju rizika.
English: - Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus in adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance (see section 4.4).
Croatian: - Pioglitazon je također indiciran u kombinaciji s inzulinom u odraslih bolesnika sa šećernom bolešću tipa 2 i nedostatnom kontrolom glikemije pomoću inzulina u kojih je metformin neprikladan zbog kontraindikacija ili nepodnošljivosti (vidjeti dio 4.4).
English: After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e.g. reduction in HbA1c).
Croatian: Bolesnicima treba napraviti pretrage 3 do 6 mjeseci nakon početka terapije pioglitazonom kako bi se procijenilo imaju li primjereni odgovor na liječenje (npr. smanjenje HbA1c).
English: common (may affect up to 1 in 10 people) - headache - dizziness - joint pain - impotence - back pain - shortness of breath - small reduction in red blood cell count - flatulence uncommon (may affect up to 1 in 100 people) - sugar in urine, proteins in urine - increase in enzymes - spinning sensation (vertigo) - sweating - tiredness - increased appetite
Croatian: često (mogu se javiti u do 1 na 10 osoba) - glavobolja - omaglica - bol u zglobovima - impotencija - križobolja - nedostatak zraka - malo sniženje broja crvenih krvnih stanica - nadutost manje često (mogu se javiti u do 1 na 100 osoba) - šećer u mokraći, proteini u mokraći - povišenje enzima - osjećaj vrtnje (vrtoglavica) - znojenje - umor - pojačan apetit
English: Date of first authorisation: 21 March 2012 Date of latest renewal: DD month YYYY
Croatian: Datum prvog odobrenja: 21. ožujka 2012.
English: Within each frequency grouping, adverse reactions are presented in order of decreasing incidence and seriousness.
Croatian: U svakoj skupini učestalosti nuspojave su prikazani slijedom prema sve manjoj incidenciji i ozbiljnosti.
English: The oedema rates for comparator groups (sulphonylurea, metformin) were 2 - 5%.
Croatian: Stope edema u skupinama koje su primale usporedni lijek (sulfonilureju, metformin) iznosile su 2-5%.
English: Patients should be advised to adhere strictly to a caloriecontrolled diet.
Croatian: Bolesnicima treba savjetovati da se strogo pridržavaju dijete s ograničenim unosom kalorija.
English: The other side effects that have been experienced by some patients when Pioglitazone Krka is taken with other antidiabetic medicines are:
Croatian: Druge nuspojave koje su neki bolesnici osjetili kod uzimanja lijeka Pioglitazone Krka s drugim antidijabetičkim lijekovima su:
English: Pioglitazone Krka tablets contain lactose monohydrate and therefore should not be administered to patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucosegalactose malabsorption.
Croatian: Pioglitazone Krka tablete sadrže laktozu hidrat te se stoga ne smiju primjenjivati u bolesnika s rijetkim nasljednim poremećajima nepodnošenja galaktoze, nedostatka Lapp laktaze ili malapsorpcijom glukoze-galaktoze.
English: Following initiation of therapy with pioglitazone it is recommended that liver enzymes be monitored periodically based on clinical judgement.
Croatian: Nakon početka terapije pioglitazonom preporučuje se povremeno određivati jetrene enzime na temelju kliničke procjene.
English: - Very common ( 1/10) - Common ( 1/100 to < 1/10) - Uncommon ( 1/1,000 to < 1/100) - Rare ( 1/10,000 to < 1/1,000) - Very rare (< 1/10,000) - Not known (cannot be estimated from the available data)
Croatian: - vrlo često (≥ 1/10) - često (≥ 1/100 i < 1/10) - manje često (≥ 1/1000 i < 1/100) - rijetko (≥ 1/10 000 i< 1/1000) - vrlo rijetko (< 1/10 000) - nepoznato (ne može se procijeniti iz dostupnih podataka).
English: - hypersensitivity to the active substance or to any of the excipients listed in section 6.1, - cardiac failure or history of cardiac failure (NYHA stages I to IV), - hepatic impairment, - diabetic ketoacidosis, - current bladder cancer or a history of bladder cancer, - uninvestigated macroscopic haematuria.
Croatian: - preosjetljivošću na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 6.1, - zatajenjem srca ili anamnezom zatajenja srca (NYHA stadiji I do IV), - oštećenjem funkcije jetre, - dijabetičkom ketoacidozom, - postojećim ili preboljenim karcinomom mokraćnog mjehura, - neispitanom makroskopskom hematurijom.
English: If ALT levels are increased to 3 times the upper limit of normal during pioglitazone therapy, liver enzyme levels should be reassessed as soon as possible.
Croatian: Ako se tijekom terapije pioglitazonom razine ALT povise na vrijednosti koje su 3 puta iznad gornje granice normale, razine jetrenih enzima treba čim prije ponovno provjeriti.
English: Do not use this medicine after the expiry date which is stated on the packaging after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza “Rok valjanosti”.
English: Your blood sugar will be checked, and your dose of Pioglitazone Krka may need to be changed.
Croatian: Provjerit će Vam šećer u krvi i nakon toga možda promijeniti dozu lijeka Pioglitazone Krka.
English: Frequencies are defined as: - Very common ( 1/10) - Common ( 1/100 to < 1/10) - Uncommon ( 1/1,000 to < 1/100) - Rare ( 1/10,000 to < 1/1,000) - Very rare (< 1/10,000) - Not known (cannot be estimated from the available data)
Croatian: Učestalost je navedena kao: - vrlo često (≥ 1/10) - često (≥ 1/100 i < 1/10) - manje često (≥ 1/1000 i < 1/100) - rijetko (≥ 1/10 000 i< 1/1000) - vrlo rijetko (< 1/10 000) - nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Older people
Croatian: Stariji
English: common (may affect up to 1 in 10 people) - respiratory infection - abnormal vision - weight gain - numbness uncommon (may affect up to 1 in 100 people) - inflammation of the sinuses (sinusitis) - difficulty sleeping (insomnia)
Croatian: često (mogu se javiti u do 1 na 10 osoba) - infekcija dišnih puteva - poremećen vid - povećanje tjelesne težine - utrnulost manje često (mogu se javiti u do 1 na 100 osoba) - upala sinusa (sinusitis) - poteškoće sa spavanjem (nesanica)
English: - The risk bladder cancer and relevant risk minimisation advice.
Croatian: - Rizik od karcinoma mokraćnog mjehura i odgovarajuće savjete o smanjivanju rizika.