FrancophonIA/ELRC3.0 huggingface dataset:
English: The active substance in Binocrit, epoetin alfa, is a copy of a hormone called erythropoietin, and works in exactly the same way as the natural hormone to stimulate the production of red blood cells in the bone marrow.
Slovenian: Učinkovina v zdravilu Binocrit, epoetin alfa, je kopija hormona eritropoetina in deluje popolnoma enako kot naravni hormon pri spodbujanju nastajanja rdečih krvnih celic v kostnem mozgu.
English: Binocrit contains the active substance epoetin alfa and is a ‘biosimilar medicine'.
Slovenian: Zdravilo Binocrit vsebuje učinkovino epoetin alfa in je „podobno biološko zdravilo“.
English: Binocrit is used when patients are at low or intermediate risk of developing acute myeloid leukaemia and have low levels of the natural hormone erythropoietin.
Slovenian: Zdravilo Binocrit se uporablja pri bolnikih, pri katerih obstaja majhno do srednje tveganje za pojav akutne mieloične levkemije in ki imajo nizke ravni naravnega hormona eritropoetina.
English: The reference medicine for Binocrit is Eprex/Erypo.
Slovenian: Referenčno zdravilo za zdravilo Binocrit je zdravilo Eprex/Erypo.
English: All of the patients had been receiving Eprex/Erypo injected into a vein for at least 8 weeks before they were either switched to Binocrit or remained on Eprex/Erypo.
Slovenian: Vsem bolnikom so zdravilo Eprex/Erypo najmanj osem tednov injicirali v veno, preden so bodisi začeli prejemati zdravilo Binocrit bodisi so še naprej jemali zdravilo Eprex/Erypo.
English: Binocrit can only be obtained with a prescription and treatment must be started under the supervision of a doctor who has experience in the management of patients with the conditions that Binocrit is used for.
Slovenian: Predpisovanje in izdaja zdravila Binocrit je le na recept, zdravljenje z njim pa se lahko uvede le pod nadzorom zdravnika, ki ima izkušnje z zdravljenjem bolnikov z bolezni, za katere se to zdravilo uporablja.
English: Binocrit is available in pre-filled syringes of various strengths and is given as an injection into a vein or as an injection under the skin, depending on the condition for which the patient is being treated.
Slovenian: Zdravilo Binocrit je na voljo v napolnjenih injekcijskih brizgah različnih jakosti in se daje z injiciranjem v veno ali podkožje, kar je odvisno od bolezenskega stanja bolnika, ki se zdravi.
English: The European Medicines Agency decided that, in accordance with EU requirements for biosimilar medicines, Binocrit has a highly similar structure, purity and biological activity to Eprex/Erypo and is distributed in the body in the same way.
Slovenian: Evropska agencija za zdravila je zaključila, da je bilo v skladu z zahtevami EU glede podobnih bioloških zdravil dokazano, da je zdravilo Binocrit po zgradbi, čistosti in biološkem delovanju primerljivo zdravilu Eprex/Erypo in da se po telesu enako prenaša.
English: Therefore the Agency's view was that, as for Eprex/Erypo, the benefit of Binocrit outweighs the identified risk and it can be authorised.
Slovenian: Agencija je zato menila, da koristi zdravila Binocrit enako kot pri zdravilu Eprex/Erypo odtehtajo znana tveganja in da se zdravilo lahko odobri.
English: How is Binocrit used?
Slovenian: Kako se zdravilo Binocrit uporablja?
English: For the full list of side effects of Binocrit, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Binocrit, glejte navodilo za uporabo.
English: Patients switching to Binocrit maintained haemoglobin levels to the same extent as those continuing with Eprex/Erypo.
Slovenian: Bolniki, ki so prešli na jemanje zdravila Binocrit, so ohranili enako raven hemoglobina v krvi kot bolniki, ki so nadaljevali zdravljenje z zdravilom Eprex/Erypo.
English: Laboratory studies comparing Binocrit with the reference medicine Eprex/Erypo have shown that the active substance in Binocrit is highly similar to that in Eprex/Erypo in terms of structure, purity and biological activity.
Slovenian: Laboratorijske študije, v katerih so zdravilo Binocrit primerjali z referenčnim zdravilom Eprex/Erypo, so pokazale, da je učinkovina v zdravilu Binocrit po zgradbi, čistosti in biološkem delovanju zelo podobna učinkovini v zdravilu Eprex/Erypo.
English: Studies have also shown that giving Binocrit produces similar levels of the active substance in the body to giving Eprex/Erypo.
Slovenian: Študije so pokazale tudi, da zdravilo Binocrit vzpostavi podobne ravni učinkovine v telesu kot zdravilo Eprex/Erypo.
English: In addition, studies have shown that the effects of the medicine are equivalent to those of Eprex/Erypo in increasing and maintaining blood cell counts in patients with chronic kidney failure or undergoing chemotherapy.
Slovenian: Poleg tega so študije pokazale, da so učinki tega zdravila pri zviševanju in ohranjanju ravni krvnih celic pri bolnikih s kronično odpovedjo ledvic ali tistih, ki prejemajo kemoterapijo, enakovredni učinkom zdravila Eprex/Erypo.
English: How does Binocrit work?
Slovenian: Kako zdravilo Binocrit deluje?
English: Binocrit must not be used in the following groups:
Slovenian: Zdravilo se ne sme uporabljati pri naslednjih skupinah bolnikov:
English: A further study showed that Binocrit was safe and effective when given under the skin in 416 patients with chronic kidney failure.
Slovenian: V dodatni študiji so pri 416 bolnikih s kronično odpovedjo ledvic dokazali, da je zdravilo Binocrit pri injiciranju v podkožje varno in učinkovito.
English: Binocrit, injected into a vein, was compared with the reference medicine in one main study involving 479 patients with anaemia caused by kidney problems.
Slovenian: V eni glavni študiji, ki je vključevala 479 bolnikov z anemijo, povezano z obolenjem ledvic, so zdravilo Binocrit, injicirano v veno, primerjali z referenčnim zdravilom.
English: In addition, Binocrit was shown to be as effective as Eprex/Erypo at increasing and maintaining red blood cell counts in several studies.
Slovenian: Poleg tega so v več študijah dokazali, da je zdravilo Binocrit pri zviševanju in ohranjanju števila rdečih krvnih celic enako učinkovito kot zdravilo Eprex/Erypo.
English: Another study showed that Binocrit injected under the skin was as effective in maintaining haemoglobin levels as Eprex/Erypo in 114 cancer patients who were receiving chemotherapy.
Slovenian: Druga študija pri 114 bolnikih z rakavimi obolenji, ki so prejemali kemoterapijo, je pokazala, da je zdravilo Binocrit, injicirano v podkožje, enako učinkovito za ohranjanje ravni hemoglobina v krvi kot zdravilo Eprex/Erypo.
English: You need to keep taking it every day to stop your illness getting worse.
Slovenian: Morate ga jemati vsak dan, da se vaša bolezen ne bo slabšala.
English: Repeat steps 3 to 7 in the same way until you have taken your whole dose.
Slovenian: št. od 3 do 7 ponavljajte na enak način, dokler ne vzamete vašega celotnega odmerka.
English: If you notice any of these symptoms:
Slovenian: Če opazite kateregakoli od teh simptomov:
English: These differences were observed in each different age group studied.
Slovenian: Te razlike so bile opažene v vsaki preiskovani starostni skupini.
English: The dose should therefore be adjusted (see tables).
Slovenian: Odmerek je torej potrebno prilagoditi (glejte tabele).
English: So it is very important to talk to your doctor about any changes in your health.
Slovenian: Zato je zelo pomembno, da se z zdravnikom pogovorite o vseh spremembah, ki jih opazite glede vašega zdravja.
English: Stay in regular contact with your doctor
Slovenian: Bodite v rednem stiku z zdravnikom
English: Sucrose may be harmful to the teeth.
Slovenian: Saharoza ima lahko škodljiv učinek na zobe.
English: Pancreatitis: Cases of pancreatitis have occurred rarely.
Slovenian: Pankreatitis: Primeri pankreatitisa so bili redki.
English: For example, if your dose is 15 ml, you need to take one and a half syringe-fulls of medicine.
Slovenian: Na primer če je vaš odmerek 15 ml, morate vzeti eno in pol napolnjeno brizgo z zdravilom.
English: • if you are seriously overweight (especially if you are a woman)
Slovenian: • če imate prekomerno telesno težo (še posebej, če ste ženska),
English: This is consistent with the lower rates of antiviral suppression observed in these patients.
Slovenian: To je skladno z nižjimi stopnjami protivirusne supresije, ki so jo opazili pri teh bolnikih.
English: United Kingdom.
Slovenian: Velika Britanija.
English: It should be taken into account that data for the once daily regimen are very limited in this population (see sections 4.4, 5.1 and 5.2).
Slovenian: Treba je upoštevati, da so podatki o režimu odmerjanja enkrat na dan za to populacijo omejeni (glejte poglavje 4.4, 5.1 in 5.2).
English: VIIVHIV HEALTHCARE, UNIPESSOAL, LDA.
Slovenian: VIIV HIV HEALTHCARE, UNIPESSOAL, LDA
English: Frequencies are defined as very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000).
Slovenian: Pogostnost je definirana z izrazi zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10), občasni (≥1/1.000 do <1/100), redki (≥1/10.000 do <1/1.000) in zelo redki (<1/10.000).
English: Instructions for use are included in the pack.
Slovenian: Navodila za uporabo so priložena v škatli.
English: • if they are also taking anti-inflammatory medicines called corticosteroids
Slovenian: • ki jemljejo tudi protivnetna zdravila imenovana kortikosteroidi,
English: Turn the bottle upside down.
Slovenian: Obrnite zgornjo stran plastenke navzdol.
English: This medicine has been prescribed for you or for your child. Do not pass it on to others.
Slovenian: Zdravilo je bilo predpisano vam ali vašemu otroku in ga ne smete dajati drugim.
English: Absorption differences have been observed between adult and paediatric populations (see Special populations).
Slovenian: Pri odraslih in pediatrični populaciji je bila opažena razlika v absorpciji (glejte Posebne populacije).
English: Following oral administration, the mean time (tmax) to maximal serum concentrations (Cmax) is about an hour.
Slovenian: Po peroralnem dajanju je srednji čas (tmax) do maksimalnih serumskih koncentracij (Cmax) približno ena uro.
English: This conclusion is based on the physiochemical and pharmacokinetic data assuming that the patient crushes and transfers 100% of the tablet and ingests immediately.
Slovenian: Ta zaključek temelji na fizikalno-kemijskih in farmakokinetičnih podatkih na predpostavki, da bolnik zdrobi in prenese 100 % tablete ter jo takoj zaužije.
English: Epivir does not completely cure HIV infection; it reduces the amount of virus in your body, and keeps it at a low level.
Slovenian: Zdravilo Epivir ne pozdravi popolnoma okužbe z virusom HIV, vendar zmanjša količino virusa v telesu in jo vzdržuje na nizki ravni.
English: The observed half-life of elimination is 5 to 7 hours.
Slovenian: Opazovan eliminacijski razpolovni čas lamivudina znaša 5 do 7 ur.
English: Aspen Bad Oldesloe GmbH Industriestrasse 32-36 23843 Bad Oldesloe Germany
Slovenian: Aspen Bad Oldesloe GmbH Industriestrasse 32-36 23843 Bad Oldesloe Nemčija
English: CD4 cells are a type of white blood cells that are important in helping your body to fight infection.
Slovenian: Celice CD4 so vrsta belih krvnih celic, ki opravljajo pomembno vlogo v boju z okužbo.
English: The results of long-term carcinogenicity studies in rats and mice did not show any carcinogenic potential relevant for humans.
Slovenian: Rezultati dolgoročnih raziskav karcinogenosti lamivudina pri podganah in miših niso pokazali karcinogenega potenciala, ki bi bil pomemben za človeka.
English: • an increase in the level of liver enzymes.
Slovenian: • povečane vrednosti jetrnih encimov.
English: Do not take a double dose to make up for a forgotten dose.
Slovenian: Ne vzemite dvojnega odmerka, da bi nadoknadili izpuščeni odmerek.
English: mannitol, lactitol or maltitol), if taken regularly
Slovenian: manitol, laktitol, maltitol), če se jemljejo redno,
English: The tablets also contain the following other ingredients:
Slovenian: Tablete vsebujejo tudi naslednje pomožne snovi:
English: Remember to tell your doctor or pharmacist if you begin taking a new medicine while you are taking Epivir.
Slovenian: Ne pozabite povedati zdravniku ali farmacevtu, če boste začeli jemati novo zdravilo, medtem ko jemljete zdravilo Epivir.
English: The frequency of which is unknown (see section 4.4).
Slovenian: Pogostnost tega ni znana (glejte poglavje 4.4).
English: If a twice daily regimen is not feasible, a once daily regimen (10 mg/kg/day) could be considered.
Slovenian: Če režim odmerjanja dvakrat na dan ni izvedljiv, se lahko razmisli o režimu odmerjanja enkrat na dan (10 mg/kg/dan).
English: 3 to 12 years (N=35)
Slovenian: Od 3 do 12 let (n = 35)
English: If you have taken Epivir during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Slovenian: Če ste zdravilo Epivir jemali med nosečnostjo, vas lahko zdravnik naroči na redne preiskave krvi in druge diagnostične preiskave, da bo spremljal razvoj vašega otroka.
English: These symptoms are probably caused by the body's immune system becoming stronger, so that the body starts to fight these infections.
Slovenian: Ti simptomi so verjetno posledica okrepitve imunskega sistema, s tem da se organizem zopet prične boriti proti tem okužbam.
English: Let it dry completely before you use it again.
Slovenian: Pred ponovno uporabo mora biti popolnoma suha.
English: Epivir helps to control your condition.
Slovenian: Zdravilo Epivir pomaga nadzorovati vaše stanje.
English: A small amount of the ingredients in Epivir can also pass into your breast milk.
Slovenian: Majhna količina sestavin zdravila Epivir lahko prehaja v materino mleko.
English: Swallow the tablet with some water.
Slovenian: Tableto pogoltnite celo z nekaj vode.
English: Pull out syringe plunger until the syringe contains the first part of your full dose.
Slovenian: Izvlecite bat odmerne brizge dokler odmerne brizge ne napolnite s prvim delom vašega celotnega odmerka.
English: Tell your doctor or pharmacist if you are taking any other medicines, or if you have taken any recently, including herbal medicines or other medicines you bought without a prescription.
Slovenian: Povejte zdravniku ali farmacevtu, če jemljete katera druga zdravila, ali ste jih pred kratkim jemali, vključno z zdravili rastlinskega izvora ali drugimi zdravili, ki ste jih kupili brez recepta.
English: Not everyone responds to treatment with Epivir in the same way.
Slovenian: Na zdravljenje z zdravilom Epivir se ne odzove vsak na enak način.
English: Important information about some of the ingredients of Epivir
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Epivir
English: Older people: No specific data are available; however, special care is advised in this age group due to age-associated changes such as the decrease in renal function and alteration of haematological parameters.
Slovenian: Starostniki: Specifičnih podatkov ni na voljo, vendar pri tej starostni skupini priporočamo posebno previdnost zaradi starostnih sprememb, npr. zmanjšanja ledvične funkcije in sprememb hematoloških parametrov.
English: • breakdown of muscle tissue
Slovenian: • razpad mišičnega tkiva,
English: Talk to your doctor immediately.
Slovenian: se takoj posvetujte z zdravnikom.
English: Epivir and similar medicines may cause side effects in unborn babies.
Slovenian: Zdravilo Epivir in podobna zdravila lahko povzročijo neželene učinke pri nerojenemu otroku.
English: Keep in touch with your doctor, and do not stop taking Epivir without your doctor's advice.
Slovenian: Bodite v stiku z zdravnikom in ne prenehajte jemati zdravila Epivir brez zdravnikovega nasveta.
English: More than 1000 outcomes from first trimester and more than 1000 outcomes from second and third trimester exposure in pregnant women indicate no malformative and foeto/neonatal effect.
Slovenian: Pri nosečnicah je znanih več kot 1000 izidov po izpostavljenosti v prvem trimesečju in več kot 1000 izidov po izpostavljenosti v drugem in tretjem trimesečju, ki ne kažejo na malformacijske učinke ali učinke na plod ali novorojenčka.
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali s pomanjkanjem saharoza-izomaltaze ne smejo jemati tega zdravila.
English: Do not take other medicines for the infection without your doctor's advice.
Slovenian: Ne jemljite drugih zdravil za zdravljenje okužbe brez zdravnikovega nasveta.
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breastfed infants of mothers treated for HIV are very low (< 4% of maternal serum concentrations) and progressively decrease to undetectable levels when breastfed infants reach 24 weeks of age.
Slovenian: Na podlagi podatkov pri več kot 200 parih mater in otrok, zdravljenih zaradi okužbe HIV, so koncentracije lamivudina v serumu dojenih otrok mater, zdravljenih zaradi okužbe s HIV, zelo majhne (manj kot 4 % koncentracije v materinem serumu) in se progresivno zmanjšujejo do nezaznavne ravni, ko dojeni otroci dosežejo 24 tednov starosti.
English: Its main mode of action is as a chain terminator of viral reverse transcription.
Slovenian: Njegov glavni način delovanja je prekinitev verige pri virusni reverzni transkripciji.
English: Women who are HIV-positive must not breast-feed, because HIV infection can be passed on to the baby in breast milk.
Slovenian: Ženske, ki so HIV pozitivne, ne smejo dojiti otrok, kajti okužba z virusom HIV se lahko z mlekom prenese na otroka.
English: Accidentally taking too much Epivir is unlikely to cause any serious problems.
Slovenian: Če ste pomotoma vzeli prevelik odmerek zdravila Epivir, je malo verjetno, da bi prišlo do kakršnihkoli resnih težav.
English: No specific signs or symptoms have been identified following such overdose.
Slovenian: Po tovrstnem prevelikem odmerjanju niso opazili nobenih specifičnih znakov ali simptomov.
English: Limited data are available on the consequences of ingestion of acute overdoses in humans.
Slovenian: Na razpolago je le nekaj podatkov o posledicah zaužitja akutnih prevelikih odmerkov pri človeku.
English: There are limited pharmacokinetic data for patients less than three months of age.
Slovenian: Za bolnike, mlajše od treh mesecev, je na voljo le nekaj farmakokinetičnih podatkov.
English: Push the plastic adapter into the neck of the bottle.
Slovenian: Potisnite plastični nastavek v vrat plastenke.
English: Pharmacokinetic data were derived from 3 pharmacokinetic studies (PENTA 13, PENTA 15 and ARROW PK substudy) enrolling children under 12 years of age.
Slovenian: Farmakokinetični podatki so bili pridobljeni iz 3 farmakokinetičnih študij (PENTA 13, PENTA 15 in FK podštudija ARROW), ki so zajele otroke do 12. leta starosti.
English: • muscle pain and discomfort
Slovenian: • bolečine v mišicah in neudobje,
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterium infections, and Pneumocystis jirovecii pneumonia (often referred to as PCP).
Slovenian: Ustrezni primeri so citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami in s Pneumocystis jirovecii povzročena pljučnica (pogosto omenjena kot PCP).
English: Lamivudine is a nucleoside analogue which has activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Slovenian: Lamivudin je nukleozidni analog, ki deluje proti virusu humane imunske pomanjkljivosti (HIV) in proti virusu hepatitisa B (HBV).
English: • Lactic acidosis (excess lactic acid in the blood)
Slovenian: • laktacidoza (čezmerno kopičenje mlečne kisline v krvi),
English: Do not push too hard and squirt the liquid into the back of your throat or you may choke.
Slovenian: Ne pritiskajte premočno in ne izpraznite tekočine prehitro v žrelo, ker se lahko zadušite.
English: When concomitant administration is warranted, patients should be monitored clinically.
Slovenian: V primeru potrebe po sočasni uporabi, je bolnike potrebno klinično nadzorovati.
English: When you are being treated for HIV, it can be hard to tell whether a symptom is a side effect of Epivir or other medicines you are taking, or an effect of the HIV disease itself.
Slovenian: Če se zdravite zaradi okužbe s HIV, je včasih težko reči ali je simptom neželeni učinek zdravila Epivir ali drugih zdravil, ki jih tudi jemljete, ali je to posledica same bolezni.
English: The adverse reactions considered at least possibly related to the treatment are listed below by body system, organ class and absolute frequency.
Slovenian: V nadaljevanju so navedeni neželeni učinki, za katere obstaja vsaj najmanjša možnost, da so povezani z zdravljenjem; razvrščeni so po telesnih sistemih, organih in po absolutni pogostnosti.
English: The 300 mg tablet is only suitable for the once a day regimen.
Slovenian: 300 mg tableta je primerna le za režim odmerjanja enkrat na dan.
English: Lamivudine has no effect on the pharmacokinetics of trimethoprim or sulfamethoxazole.
Slovenian: Lamivudin ne vpliva na farmakokinetične lastnosti trimetoprima ali sulfametoksazola.
English: If overdosage occurs the patient should be monitored, and standard supportive treatment applied as required.
Slovenian: V primeru zaužitja prevelikega odmerka je bolnika potrebno nadzirati in po potrebi uvesti standardno podporno zdravljenje.
English: Genotypic resistance analyses were conducted on samples with plasma HIV-1 RNA >1000 copies/ml.
Slovenian: Analize genotipske odpornosti so bile opravljene na vzorcih z HIV-1 RNA v plazmi > 1000 kopij/ml.
English: The mean (CV) AUC over a dosing interval of 12 hours is 4.7 µg.h/ml (18%).
Slovenian: Srednja (CV) AUC v 12-urnem odmernem intervalu je 4,7 µg.h/ml (18%).
English: Children from three months of age: As an accurate dosage cannot be achieved with the 300 mg nonscored tablet formulation in this patient population, it is recommended that the Epivir 150 mg scored tablet formulation is used and the corresponding recommended dosage instructions are followed.
Slovenian: Otroci, starejši od treh mesecev: Ker pri tej populaciji bolnikov ne moremo zagotoviti točnega odmerka s 300 mg tableto brez razdelilne zareze, je priporočljiva uporaba zdravila Epivir 150 mg tablete z razdelilno zarezo, pri čemer je potrebno slediti ustreznim priporočilom odmerjanja.
English: What Epivir is and what it is used for
Slovenian: Kaj je zdravilo Epivir in za kaj ga uporabljamo
English: The active moiety, intracellular lamivudine triphosphate, has a prolonged terminal half-life in the cell (16 to 19 hours) compared to the plasma lamivudine half-life (5 to 7 hours).
Slovenian: Aktivna oblika, znotrajcelični lamivudinov trifosfat, ima podaljšan končni razpolovni čas v celici (16 do 19 ur) v primerjavi z razpolovnim časom lamivudina v plazmi (5 do 7 ur).
English: The likelihood of metabolic interactions of lamivudine with other medicinal products is low due to the small extent of hepatic metabolism (5-10%) and low plasma protein binding.
Slovenian: Verjetnost presnovnih interakcij z drugimi zdravili je majhna zaradi majhnega obsega jetrne presnove (5 do 10%) in majhne vezave na plazemske proteine.
English: Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine.
Slovenian: Druga zdravila (npr. ranitidin, cimetidin) se le deloma izločajo s pomočjo tega mehanizma in zanje je bilo dokazano, da z lamivudinom medsebojno ne delujejo.
English: • if they have been taking combination therapy for a long time
Slovenian: • ki so prejemali kombinirano zdravljenje daljše časovno obdobje,
English: These findings should be considered for any child exposed in utero to nucleoside and nucleotide analogues, who presents with severe clinical findings of unknown etiology, particularly neurologic findings.
Slovenian: Te ugotovitve je treba upoštevati pri vseh otrokih, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom, pri katerih se pojavijo resne klinične ugotovitve neznanega vzroka, še zlasti nevrološke.