FrancophonIA/ELRC3.0 huggingface dataset:
English: The adverse reactions with suspected (at least possible) relationship to treatment are listed below by body system organ class and frequency.
Slovenian: Neželeni učinki, domnevno (vsaj morda) povezani z zdravljenjem, so navedeni spodaj po organskih sistemih in pogostnosti.
English: The EC50 values for tenofovir were in the range of 0.04-8.5 microM.
Slovenian: Vrednosti EC50 tenofovirja so bile v razponu od 0,04 do 8,5 mikroM.
English: The highest frequency category reported in the 3TC or TDF Summary of Product Characteristics is used.
Slovenian: Uporabljena je najvišja kategorija pogostnosti, navedena v povzetku glavnih značilnosti zdravila za 3TC ali TDF.
English: No dose adjustment is required.
Slovenian: Odmerka ni treba prilagoditi.
English: • medicines (usually liquids) containing sorbitol and other sugar alcohols (such as xylitol,
Slovenian: • zdravila (običajno tekočine), ki vsebujejo sorbitol ali druge sladkorne alkohole (kot so ksilitol,
English: The muscle pain, muscle weakness and decreases in potassium or phosphate in the blood may occur due to damage to kidney tubule cells.
Slovenian: Bolečine v mišicah, šibkost mišic in znižanje kalija ali fosfata v krvi se lahko pojavijo zaradi okvare celic ledvičnih tubulov.
English: Viral subtype non-B
Slovenian: Podtip virusa ne-B
English: Lamivudine is a nucleoside analogue.
Slovenian: Lamivudin je nukleozidni analog.
English: If bone abnormalities are suspected, then appropriate consultation should be obtained.
Slovenian: V primeru suma na kostne nepravilnosti je potrebno ustrezno posvetovanje.
English: During the initial phase of combination antiretroviral treatment, patients whose immune system responds may develop an inflammatory response to indolent or residual opportunistic infections (such as Mycobacterium avium infection, cytomegalovirus, Pneumocystis jirovecii pneumonia [PCP], or tuberculosis), which may necessitate further evaluation and treatment.
Slovenian: Med uvodno fazo kombiniranega protiretrovirusnega zdravljenja se lahko pri bolnikih, katerih imunski sistem se odzove, razvije vnetni odziv na indolentne ali rezidualne oportunistične okužbe (kot so npr. okužba z Mycobacterium avium, z virusom citomegalije, pljučnica zaradi Pneumocystis jirovecii [PCP] ali tuberkuloza), zaradi katerih so lahko potrebne dodatne preiskave in zdravljenje.
English: A large amount of data on pregnant women (more than 3,000 outcomes from first trimester) taking the individual active component lamivudine in combination with other antiretrovirals indicates no malformative toxicity.
Slovenian: Obsežni podatki pri nosečnicah (več kot 3.000 izidov od prvega trimesečja), ki so jemale samostojno učinkovino lamivudin v kombinaciji z drugimi protiretrovirusnimi zdravili, ne kažejo malformacijskih toksičnih učinkov.
English: While effective viral suppression with antiretroviral therapy has been proven to substantially reduce the risk of sexual transmission of HIV-1, a residual risk cannot be excluded.
Slovenian: Dokazano je sicer, da učinkovita supresija virusov s protiretrovirusnim zdravljenjem bistveno zmanjša tveganje za spolni prenos HIV-1, vendar določenega preostalega tveganja ni mogoče izključiti.
English: In a population pharmacokinetic analysis, which included subjects with CrCl between 17 and 317 mL/min, renal function did not have a clinically relevant effect on doravirine pharmacokinetics.
Slovenian: V populacijski farmakokinetični analizi, ki je vključevala preiskovance z očistkom kreatinina med 17 in 317 ml/min, delovanje ledvic ni klinično pomembno vplivalo na farmakokinetiko doravirina.
English: EC50 values were in the range of 0.003 to 15 microM (1 microM = 0.23 micrograms per mL).
Slovenian: Vrednosti EC50 so bile v razponu od 0,003 do 15 mikroM (1 mikroM = 0,23 mikrograma na ml).
English: Patients who are co-infected with HIV-1 and HBV should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment with Delstrigo.
Slovenian: Bolnike, ki so sočasno okuženi s HIV-1 in HBV, je treba natančno klinično in laboratorijsko spremljati vsaj še nekaj mesecev po prenehanju zdravljenja z zdravilom Delstrigo.
English: If you have HIV infection and hepatitis B infection, it is especially important not to stop your Delstrigo treatment without talking to your doctor first.
Slovenian: Če ste okuženi s HIV in s hepatitisom B, je še posebej pomembno, da z zdravljenjem z zdravilom Delstrigo ne prenehate, ne da bi se prej posvetovali z zdravnikom.
English: Ribavirin (50 microM) used in the treatment of chronic HCV infection decreased the anti-HIV-1 activity of lamivudine by 3.5-fold in MT-4 cells.
Slovenian: Ribavirin (50 mikroM), uporabljen pri zdravljenju kronične okužbe s HCV, je v celicah MT-4 zmanjšal aktivnost lamivudina proti HIV-1 za 3,5-krat.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Slovenian: V študijah na živalih lamivudin ni bil teratogen, obstajali pa so znaki večjega števila zgodnjih smrti zarodkov pri kuncih ob razmeroma majhnih sistemskih izpostavljenostih, primerljivih tistim, ki so dosežene pri človeku.
English: Delstrigo is a complete regimen for the treatment of HIV-1 infection; therefore, Delstrigo should not be administered with other antiretroviral medicinal products.
Slovenian: Zdravilo Delstrigo je popolna shema za zdravljenje okužbe s HIV-1, zato se ga ne sme uporabljati z drugimi protiretrovirusnimi zdravili.
English: • if you are allergic to doravirine, lamivudine or tenofovir disoproxil or any of the other ingredients of this medicine listed in section 6.
Slovenian: • če ste alergični na doravirin, lamivudin, dizoproksiltenofovirat ali katero koli sestavino tega zdravila, navedeno v poglavju 6.
English: It is unknown whether doravirine is excreted in human milk.
Slovenian: Ni znano, ali se doravirin pri človeku izloča v materino mleko.
English: If appropriate, initiation of anti-hepatitis B therapy may be warranted, especially in patients with advanced liver disease or cirrhosis, since post-treatment exacerbation of hepatitis may lead to hepatic decompensation and liver failure.
Slovenian: Če je primerno, je lahko potrebna uvedba zdravljenja proti hepatitisu B, zlasti pri bolnikih z napredovalo boleznijo jeter ali cirozo, kajti poslabšanje hepatitisa po zdravljenju lahko povzroči jetrno dekompenzacijo in odpoved jeter.
English: • This medicinal product does not require any special temperature storage conditions.
Slovenian: • Za shranjevanje zdravila niso potrebna posebna navodila glede temperature.
English: Week 48 N=447
Slovenian: 48. teden N = 447
English: Doravirine 100 mg once daily
Slovenian: Doravirin 100 mg enkrat na dan
English: Studies with lamivudine show that plasma concentrations (AUC) are increased in patients with renal dysfunction due to decreased clearance.
Slovenian: Rezultati študije z lamivudinom kažejo, da se koncentracija v plazmi (AUC) pri bolnikih z motenim delovanjem ledvic zaradi manjšega očistka poveča.
English: Genotypic analysis showed that the resistance was due to a specific amino acid substitution in the HIV-1 RT at codon 184 changing the methionine to either isoleucine or valine (M184V/I).
Slovenian: Genotipska analiza je pokazala, da je bila odpornost posledica specifične aminokislinske substitucije v RT HIV-1 na kodonu 184 s spremembo metionina ali v izolevcin ali v valin (M184V/I)
English: Based on administration of an IV microdose, the volume of distribution of doravirine is 60.5 L. Doravirine is approximately 76 % bound to plasma proteins.
Slovenian: Na podlagi uporabe intravenskega mikroodmerka je volumen porazdelitve doravirina 60,5 l. Doravirin je približno v 76 % vezan na beljakovine v plazmi.
English: In some patients with advanced liver disease or cirrhosis, stopping treatment is not recommended as this may lead to worsening of your hepatitis, which may be life-threatening.
Slovenian: Pri nekaterih bolnikih z napredovalo boleznijo jeter ali cirozo prenehanje zdravljenja ni priporočljivo, ker lahko povzroči poslabšanje hepatitisa, to pa je lahko življenjsko nevarno.
English: Following oral administration, the terminal halflife of tenofovir is approximately 12 to 18 hours.
Slovenian: Terminalni razpolovni čas tenofovirja po peroralni uporabi je približno 12 do 18 ur.
English: Because of the potential for HIV-1 transmission and the potential for serious adverse reactions in breast-feeding infants, mothers should be instructed not to breast-feed if they are receiving Delstrigo.
Slovenian: Zaradi možnosti prenosa HIV-1 z matere na otroka in zaradi potencialno nevarnih neželenih učinkov pri dojenih otrocih je treba matere podučiti, naj ne dojijo, če prejemajo zdravilo Delstrigo.
English: At baseline, the median age of subjects was 43 years, 16 % were female, and 24 % were nonwhite.
Slovenian: Izhodiščno je bila mediana starost preiskovancev 43 let, 16 % je bilo žensk in 24 % preiskovancev ni bilo belcev.
English: Miscellaneous sorbitol solution (3.2 g, 10.2 g, 13.4 g)/lamivudine
Slovenian: Razno raztopina sorbitola (3,2 g, 10,2 g, 13,4 g)/lamivudin
English: There is not sufficient clinical evidence to support the use of doravirine in patients infected with HIV-1 with evidence of resistance to the NNRTI class.
Slovenian: Ni zadostnih kliničnih dokazov za podporo uporabi doravirina pri bolnikih, okuženih z virusom HIV-1, ki imajo dokazano odpornost proti NNRTI.
English: Of the 7 subjects who developed high level doravirine resistance in the pivotal studies, 6 had phenotypic resistance to EFV and nevirapine, 3 to rilpivirine, and 2 had partial resistance to etravirine based on the Monogram Phenosense assay.
Slovenian: Od 7 preiskovancev, ki se jim je v ključnih študijah pojavila visoka raven odpornosti proti doravirinu, jih je 6 imelo fenotipsko odpornost proti efavirenzu in nevirapinu, 3 proti rilpivirinu, 2 pa sta imela na podlagi preizkusa Monogram Phenosense delno odpornost proti etravirinu.
English: Delstrigo is used to treat HIV (‘human immunodeficiency virus') infection.
Slovenian: Zdravilo Delstrigo se uporablja za zdravljenje okužbe z virusom HIV (virusom humane imunske pomanjkljivosti).
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breast-fed infants of mothers treated for HIV are very low (< 4 % of maternal serum concentrations) and progressively decrease to undetectable levels when breast-fed infants reach 24 weeks of age.
Slovenian: Določitev pri več kot 200 parih mater in otrok, zdravljenih zaradi HIV, je pokazala, da je koncentracija lamivudina v serumu dojenih dojenčkov mater, zdravljenih zaradi HIV, zelo majhna (manj kot 4 % koncentracije v materinem serumu) in se progresivno zmanjša do nezaznavne ravni, ko dojenček doseže 24 tednov starosti.
English: Tenofovir diphosphate inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5´-triphosphate and, after incorporation into DNA, by DNA chain termination.
Slovenian: Tenofovirdifosfat zavira aktivnost RT HIV-1 s tekmovanjem z naravnim substratom deoksiadenozin 5'-trifosfatom in - po vključitvi v DNA - z zaključitvijo verige DNA.
English: Administration of doravirine in animal toxicity studies was not associated with toxicity.
Slovenian: Doravirin Uporaba doravirina v študijah toksičnosti na živalih ni bila povezana s toksičnimi učinki.
English: NNRTI-associated mutations detected at screening were part of exclusion criteria in the Phase 2b/3-studies.
Slovenian: Z NNRTI povezane mutacije, ugotovljene ob presejanju, so bile v študijah faz 2b/3 eno od meril za nevključitev.
English: Talk with your doctor about the best way to feed your baby.
Slovenian: O najustreznejšem načinu hranjenja otroka se posvetujte z zdravnikom.
English: • muscle symptoms (pain, stiffness)
Slovenian: • mišični simptomi (bolečine, togost)
English: Special care is advised in this age group due to age associated changes such as decreases in renal function (see section 4.4).
Slovenian: Posebna previdnost je v tej starostni skupini potrebna zaradi starostnih sprememb, npr. zmanjšanega delovanja ledvic (glejte poglavje 4.4).
English: The DRIVE-SHIFT study included virologically suppressed patients (N=670) with no history of treatment failure (see section, Clinical experience).
Slovenian: V študiji DRIVE-SHIFT so bili vključeni virološko suprimirani bolniki (N = 670), ki v anamnezi niso imeli neuspeha zdravljenja (glejte naslednje poglavje, Klinične izkušnje).
English: Delstrigo contains the active substances:
Slovenian: Zdravilo Delstrigo vsebuje naslednje učinkovine:
English: If you have both HIV and hepatitis B virus infections, your hepatitis B may get worse if you stop taking Delstrigo.
Slovenian: Če ste okuženi z virusom HIV in virusom hepatitisa B, se vam hepatitis B lahko poslabša, če nehate jemati zdravilo Delstrigo.
English: If you take more Delstrigo than you should Do not take more than the recommended dose.
Slovenian: Če ste vzeli večji odmerek zdravila Delstrigo, kot bi smeli Ne vzemite odmerka, večjega od priporočenega.
English: Safety and efficacy of Delstrigo have not been established in patients younger than 18 years of age.
Slovenian: Varnost in učinkovitost zdravila Delstrigo pri bolnikih, mlajših od 18 let, nista bili dokazani.
English: Approximately 71 % of an intravenous dose of lamivudine is recovered as unchanged medicinal product in the urine.
Slovenian: Približno 71 % intravenskega odmerka lamivudina se izloči z urinom kot nespremenjeno zdravilo.
English: Based on the results of in vitro experiments and the known elimination pathway of tenofovir, the potential for CYP-mediated interactions involving tenofovir with other medicinal products is low.
Slovenian: Glede na rezultate poskusov in vitro in znane poti odstranjevanja tenofovirja je možnost za medsebojna delovanja tenofovirja in drugih zdravil preko CYP majhna.
English: The following de novo resistance was seen in the resistance analysis subset (subjects with HIV-1 RNA greater than 400 copies per mL at virologic failure or at early study discontinuation and having resistance data).
Slovenian: Naslednjo de novo odpornost so ugotovili v podskupini za analizo odpornosti (preiskovanci, ki so imeli HIV-1 RNA več kot 400 kopij/ml ob virološkem neuspehu ali zgodnjem prenehanju sodelovanja v študiji ter so zanje imeli podatke o odpornosti).
English: At baseline, the median age of subjects was 33 years (range 18 to 69 years), 86 % had CD4
Slovenian: V izhodišču je bila mediana starost preiskovancev 33 let (razpon: od 18 do 69 let), 86 % jih je imelo število celic T CD4
English: Endothelin Receptor Antagonists bosentan
Slovenian: Antagonisti endotelinskih receptorjev bosentan
English: What Delstrigo is and what it is used for
Slovenian: Kaj je zdravilo Delstrigo in za kaj ga uporabljamo
English: The principal mode of action of 3TC-TP is inhibition of RT via DNA chain termination after incorporation of the nucleotide analogue.
Slovenian: Glavni način delovanja 3TC-TP je zavrtje RT z zaključitvijo verige DNA po vgradnji nukleotidnega analoga.
English: Animal studies with lamivudine showed an increase in early embryonic deaths in rabbits but not in rats (see section 5.3).
Slovenian: Rezultati študij na živalih z lamivudinom so pokazali porast zgodnjih smrti zarodkov pri kuncih, ne pa pri podganah (glejte poglavje 5.3).
English: Talk to your doctor before taking the following medicines with Delstrigo as your doctor may need to change the dose of your medicines:
Slovenian: Preden vzamete katero od naslednjih zdravil skupaj z zdravilom Delstrigo, se posvetujte z zdravnikom, kajti morda vam bo moral spremeniti odmerek vaših zdravil:
English: Lamivudine-resistant HIV-1 mutants were also cross resistant to didanosine (ddI).
Slovenian: Proti lamivudinu odporni mutanti HIV-1 so bili tudi navzkrižno odporni proti didanozinu (ddI).
English: There are some medicines you must not take with Delstrigo.
Slovenian: Nekaterih zdravil ne smete jemati skupaj z zdravilom Delstrigo.
English: Approximately 70-80 % of the intravenous dose of tenofovir is recovered as unchanged medicinal product in the urine within 72 hours of dosing.
Slovenian: Približno 70 do 80 % intravenskega odmerka tenofovirja se v 72 urah po uporabi pojavi v urinu kot nespremenjeno zdravilo.
English: In HIV-1-infected subjects, total clearance was 398.5 ± 69.1 mL per min (mean ± SD).
Slovenian: Pri preiskovancih, okuženih s HIV-1, je bil celotni očistek 398,5 ± 69,1 ml na minuto (povprečje ± standardni odklon).
English: In a study comparing 8 subjects with severe renal impairment to 8 subjects without renal impairment, the single dose exposure of doravirine was 31 % higher in subjects with severe renal impairment.
Slovenian: V študiji, v kateri so primerjali 8 preiskovancev s hudo okvaro ledvic in 8 preiskovancev brez okvare ledvic, je bila izpostavljenost po enkratnem odmerku doravirina pri preiskovancih s hudo okvaro ledvic za 31 % večja.
English: 2031 BN Haarlem NETHERLANDS
Slovenian: 2031 BN Haarlem Nizozemska
English: • cough, nasal symptoms
Slovenian: • kašelj, nosni simptomi
English: The K65R substitution in HIV-1 RT selected by tenofovir is also selected in some HIV-1 infected patients treated with abacavir or didanosine.
Slovenian: Substitucija K65R v RT HIV-1, selekcionirana s tenofovirjem, je selekcionirana tudi pri nekaterih s HIV-1 okuženih bolnikih, zdravljenih z abakavirjem ali didanozinom.
English: The recommended dose of Delstrigo is one 100/300/245 mg tablet taken orally once daily with or without food.
Slovenian: Priporočeni odmerek zdravila Delstrigo je ena 100/300/245-mg tableta peroralno enkrat na dan s hrano ali brez nje.
English: Doravirine was excreted into the milk of lactating rats following oral administration, with milk concentrations approximately 1.5 times that of maternal plasma concentrations.
Slovenian: Doravirin se je po peroralni uporabi izločal v mleko doječih podgan; koncentracija v mleku je bila približno 1,5-krat večja kot koncentracija v materini plazmi.
English: What you need to know before you take Delstrigo
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Delstrigo
English: Doravirine has been evaluated in a limited number of patients with NNRTI resistance (K103N n = 7, G190A n = 1); all patients were suppressed to < 40 copies/mL at Week 48.
Slovenian: Doravirin so ovrednotili pri majhnem številu bolnikov z odpornostjo proti NNRTI (K103N n = 7, G190A n = 1); vsi bolniki so bili 48. teden suprimirani na < 40 kopij/ml.
English: Lamivudine may inhibit cellular DNA replication (see section 5.3).
Slovenian: Lamivudin lahko zavira replikacijo celične DNA (glejte poglavje 5.3).
English: Available pharmacodynamic/toxicological data in animals have shown excretion of doravirine in milk (see section 5.3).
Slovenian: Razpoložljivi farmakodinamični/toksikološki podatki pri živalih so pokazali, da se doravirin izloča v mleko (glejte poglavje 5.3).
English: *NRTI in DOR arm: FTC/TDF (333) or ABC/3TC (50); NRTI in DRV+r arm: FTC/TDF (335) or ABC/3TC (48) **Subjects received FTC/TDF
Slovenian: *NRTI-ji v skupini z DOR: FTC/TDF (333) ali ABC/3TC (50); NRTI-ji v skupini z DRV+r: FTC/TDF (335) ali ABC/3TC
English: Following a single 245 mg dose of tenofovir disoproxil, a 4-hour hemodialysis session removed approximately 10 % of the administered tenofovir dose.
Slovenian: Po enkratnem 245-mg odmerku dizoproksiltenofovirata je 4-urna hemodializa odstranila približno 10 % uporabljenega odmerka tenofovirja.
English: Steady state was generally achieved by Day 2 of once daily dosing, with accumulation ratios of 1.2 to 1.4 for AUC0-24, Cmax, and C24.
Slovenian: Stanje dinamičnega ravnovesja je bilo na splošno doseženo 2. dan odmerjanja enkrat na dan; razmerja kopičenja za AUC0-24, Cmax in C24 so bila med 1,2 in 1,4.
English: The bone toxicity in young adult rats and dogs occurred at exposures ≥ 5-fold the exposure in paediatric or adult patients; bone toxicity occurred in juvenile infected monkeys at very high exposures following subcutaneous dosing (≥ 40-fold the exposure in patients).
Slovenian: Toksičnost za kosti se je pri mladih odraslih podganah in psih pojavila pri izpostavljenosti, ki je bila ≥ 5-krat večja kot izpostavljenost pri pediatričnih ali odraslih bolnikih; pri mladih okuženih opicah pa se je toksičnost za kosti pojavila pri zelo velikih izpostavljenostih po subkutani uporabi (≥ 40-kratnik izpostavljenosti pri bolnikih).
English: Virologically suppressed adult subjects
Slovenian: Virološko suprimirani odrasli preiskovanci
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Delstrigo in one or more subsets of the paediatric population in treatment of human immunodeficiency virus-1 (HIV-1) infection, as per Paediatric Investigation Plans (PIP) decision in the granted indication.
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Delstrigo za eno ali več podskupin pediatrične populacije za zdravljenje okužbe s HIV-1 pod pogoji, ki so za odobreno indikacijo zdravila navedeni v izvedbenem načrtu za pediatrično populacijo (PIPPaediatric Investigation Plan).
English: See also the list in section “Other Medicines and Delstrigo”.
Slovenian: Glejte tudi seznam v poglavju "Druga zdravila in zdravilo Delstrigo".
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Slovenian: Zdravljenje mora uvesti zdravnik, ki ima izkušnje z zdravljenjem oseb, ki so okužene z virusom HIV.
English: In most singledose trials in HIV-1 infected subjects, or healthy subjects with serum sampling for 24 hours after dosing, the observed mean elimination half-life (t½) ranged from 5 to 7 hours.
Slovenian: V večini preskušanj z enkratnim odmerkom pri osebah, okuženih s HIV-1 ali zdravih osebah, z vzorčenjem seruma 24 ur po odmerku je bil opaženi povprečni eliminacijski razpolovni čas (t½) od 5 do 7 ur.
English: • reducing the amount of HIV in your blood (this is called your ‘viral load')
Slovenian: • zmanjša količino virusa HIV v krvi (tako imenovano "virusno breme"),
English: Cystic Fibrosis Treatment lumacaftor
Slovenian: Zdravila za cistično fibrozo lumakaftor
English: Safety and efficacy of lamivudine have not been established in the presence of decompensated liver disease.
Slovenian: Varnost in učinkovitost lamivudina pri bolnikih z dekompenzirano boleznijo jeter nista dokazani.
English: Tenofovir Cmax decreased by 12 % and AUC increased by 27 % with a high fat meal.
Slovenian: Cmax tenofovirja se je z zelo mastnim obrokom zmanjšala za 12 %, AUC pa se je povečala za 27 %.
English: Bone loss and mineralisation defects
Slovenian: Izgubljanje kostnine in motnje mineralizacije
English: • The bottle contains desiccant protecting the tablets from moisture.
Slovenian: • Plastenka vsebuje sušilo, ki tablete varuje pred vlago.
English: • modafinil (a medicine to treat excessive sleepiness)
Slovenian: • modafinil (zdravilo za zdravljenje prekomerne zaspanosti),
English: Although a limited number of subjects aged 65 years and over has been included (n = 36), no clinically relevant differences in the pharmacokinetics of doravirine have been identified in subjects at least 65 years of age compared to subjects less than 65 years of age in a Phase 1 trial or in a population pharmacokinetic analysis.
Slovenian: Čeprav je bilo vključenih le malo preiskovancev, starih 65 let ali več (n = 36), v preskušanju 1. faze oz. v populacijski farmakokinetični analizi niso ugotovili klinično pomembnih razlik v farmakokinetiki doravirina med preiskovanci, starimi vsaj 65 let, in preiskovanci, mlajšimi od 65 let.
English: Kinase Inhibitors dabrafenib
Slovenian: Zaviralci kinaz dabrafenib
English: However, co-administration of doravirine and the sensitive CYP3A substrate midazolam resulted in a 18 % decrease in midazolam exposure, suggesting that doravirine may be a weak CYP3A inducer.
Slovenian: Vendar pa je sočasna uporaba doravirina in občutljivega substrata CYP3A midazolama za 18 % zmanjšala izpostavljenost midazolamu; to kaže, da doravirin morda šibko inducira CYP3A.