FrancophonIA/ELRC3.0 huggingface dataset:
English: Very common: may affect more than 1 in 10 people ▪ Nausea (feeling sick)
Slovenian: Zelo pogosti: pojavijo se lahko pri več kot 1 od 10 bolnikov • slabost s siljenjem na bruhanje
English: Effect of parecoxib (or its active metabolite valdecoxib) on the pharmacokinetics of other medicinal products
Slovenian: Vpliv parekoksiba (ali njegovega aktivnega presnovka valdekoksiba) na farmakokinetiko drugih zdravil
English: COX-2 is also involved in ovulation, implantation and closure of the ductus arteriosus, regulation of renal function, and central nervous system functions (fever induction, pain perception and cognitive function).
Slovenian: COX-2 je vpletena tudi v ovulacijo, implantacijo, zaprtje arterioznega duktusa, regulacijo delovanja ledvic in v nekatere funkcije osrednjega živčevja (sprožitev zvišane telesne temperature, zaznavanje bolečine in kognitivne funkcije).
English: Injury, poisoning and procedural complications Post procedural complication (skin)
Slovenian: Poškodbe in zastrupitve in zapleti pri posegih Zapleti po posegih (na koži)
English: When adjusted for body weight, steady state plasma exposure of valdecoxib was 16% higher in elderly females compared to elderly males (see section 4.2).
Slovenian: Po prilagoditvi glede na telesno maso je bila ravnotežna plazemska izpostavljenost valdekoksibu pri starejših ženskah 16 % večja kot pri starejših moških (glejte poglavje 4.2).
English: What Dynastat is and what it is used for What you need to know before you use Dynastat How to use Dynastat
Slovenian: Kaj je zdravilo Dynastat in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Dynastat Kako uporabljati zdravilo Dynastat Možni neželeni učinki
English: There are no data indicating less overall adverse events associated with the use of parecoxib compared to placebo when used in conjunction with opioids.
Slovenian: Ni podatkov, ki bi kazali na manjše celokupno število neželenih dogodkov pri uporabi parekoksiba v primerjavi s placebom ob sočasnem jemanju opioidov.
English: The concomitant use of parecoxib with other non- acetylsalicylic acid NSAIDs should be avoided.
Slovenian: Sočasni uporabi parekoksiba z ostalimi ne-aspirinskimi NSAID se je treba izogibati.
English: Excipient with known effect This medicinal product contains less than 1 mmol sodium (23 mg) per dose.
Slovenian: Pomožna snov z znanim učinkom To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na odmerek.
English: Steady state plasma concentrations of valdecoxib were reached within 4 days with twice daily dosing.
Slovenian: Ravnotežna koncentracija valdekoksiba v plazmi je bila pri odmerjanju dvakrat na dan dosežena v 4 dneh.
English: In short-term studies (7 days), the incidence of endoscopically observed gastroduodenal ulcers or erosions in healthy young and elderly ( 65 years) subjects administered Dynastat (5-21%), although higher than placebo (5-12%), was statistically significantly lower than the incidence observed with NSAIDs (66-90%).
Slovenian: V kratkotrajnih (7-dnevnih) študijah je bila incidenca endoskopsko ugotovljenih gastroduodenalnih razjed ali erozij pri zdravih mladih in starejših (≥ 65 let) preskušancih, ki so dobili zdravilo Dynastat (5 do 21 %), sicer večja kot pri placebu (5 do 12 %), vendar statistično pomembno manjša kot pri uporabi nesteroidnih protivnetnih zdravilih (66 do 90 %).
English: Placebo/valdecoxib treatment was also associated with a higher incidence of CV thromboembolic events versus placebo treatment, but this difference did not reach statistical significance.
Slovenian: Zdravljenje s placebom/valdekoksibom je bilo prav tako povezano z višjo pojavnostjo kardioavskularnih/trombemboličnih dogodkov v primerjavi s tistimi, ki so prejemali placebo, vendar ta razlika statistično ni pomembna.
English: The occurrence of adverse events in patients receiving parecoxib for 4-7 days (median duration 4 days) was low after treatment Day 3 and similar to placebo.
Slovenian: Število neželenih dogodkov pri bolnikih, ki so dobivali parekoksib 4-7 dni (mediano trajanje 4 dni), je bilo po 3 dneh zdravljenja majhno in podobno kot pri uporabi placeba.
English: Pre-specified events that occurred with the highest incidence in all three treatment groups involved the category of surgical wound complications, including deep surgical infections and sternal wound healing events.
Slovenian: Vnaprej določeni dogodki, ki so se najpogosteje pojavljali v vseh treh obravnavanih skupinah, so vključevali zaplete v zvezi s kirurško rano, vključno z globokimi infekcijami kirurške rane in dogodki pri zdravljenju rane na prsnici.
English: During the first and second trimester of pregnancy, Dynastat should not be given unless clearly necessary.
Slovenian: Zdravila Dynastat ne smemo uporabljati v prvem in drugem trimesečju nosečnosti, razen če je nujno potrebno.
English: AUC and Cmax following twice daily administration is linear up to 50 mg IV and 20 mg IM.
Slovenian: AUC in Cmax po uporabi dvakrat na dan sta linearna do 50 mg i.v.
English: Dynastat can lead to an increase in blood pressure or worsening of existing high blood pressure which may result in an increase in side-effects associated with heart conditions.
Slovenian: Zdravilo Dynastat lahko povzroči zvišanje krvnega tlaka ali poslabšanje obstoječega zvišanega krvnega tlaka, kar lahko posledično poveča pogostnost neželenih učinkov povezanih z boleznimi srca.
English: Modes of administration other than IV or IM (e.g. intra-articular, intrathecal) have not been studied and should not be used.
Slovenian: Drugih načinov aplikacije, z izjemo intravenskega ali intramuskularnega (npr. intraartikularna, intratekalna aplikacija), niso preučevali in se jih ne sme uporabljati.
English: In addition, the following rare, serious adverse reactions have been reported in association with the use of NSAIDs and cannot be ruled out for Dynastat: bronchospasm and hepatitis.
Slovenian: Poleg tega so bili med uporabo nesteroidnih protivnetnih zdravil opisani naslednji redki, resni neželeni učinki, ki jih pri zdravilu Dynastat ni mogoče izključiti: bronhospazem in hepatitis.
English: Patients with significant risk factors for cardiovascular events (e.g. hypertension, hyperlipidaemia, diabetes mellitus, smoking) should only be treated with parecoxib after careful consideration (see section 5.1).
Slovenian: Bolnike s pomembnimi dejavniki tveganja za srčnožilne dogodke (npr. hipertenzija, hiperlipidemija, diabetes mellitus, kajenje) lahko zdravimo s parekoksibom le po skrbnem premisleku (glejte poglavje
English: Therefore, patients receiving oral anticoagulants should be closely monitored for their prothrombin time INR, particularly in the first few days when therapy with parecoxib is initiated or the dose of parecoxib is changed (see section 4.4).
Slovenian: Zato je pri bolnikih, ki dobivajo peroralne antikoagulante, treba natančno nadzirati protrombinski čas oz. INR, zlasti v prvih dneh po začetku zdravljenja s parekoksibom ali spremembi njegovega odmerka (glejte poglavje 4.4).
English: Because of the possibility for increased adverse reactions at higher doses of parecoxib, other COX-2 inhibitors and NSAIDs, patients treated with parecoxib should be reviewed following dose increase and, in the absence of an increase in efficacy, other therapeutic options should be considered (see section 4.2).
Slovenian: Zaradi možnosti številnejših neželenih učinkov pri večjih odmerkih parekoksiba, drugih zaviralcev COX-2 in nesteroidnih protivnetnih zdravil, je treba bolnike, ki dobivajo parekoksib, po zvečanju odmerka ponovno pregledati in v primeru, da se učinkovitost ne zveča, pretehtati druge terapevtske možnosti (glejte poglavje 4.2).
English: Moderate hepatic impairment did not result in a reduced rate or extent of parecoxib conversion to valdecoxib.
Slovenian: Zmerna okvara jeter ni zmanjšala hitrosti ali obsega pretvorbe parekoksiba v valdekoksib.
English: Hypersensitivity reactions including anaphylaxis and angioedema
Slovenian: Preobčutljivostne reakcije, vključno z anafilaktičnimi reakcijami in angioedemom
English: Reconstitution solvents Acceptable solvents for reconstitution of Dynastat are:
Slovenian: Vehikli za rekonstitucijo Dovoljeni vehikli za rekonstitucijo raztopine zdravila Dynastat so:
English: There is limited clinical experience with Dynastat treatment beyond three days.
Slovenian: Kliničnih izkušenj z več kot tridnevno uporabo zdravila Dynastat je malo.
English: No unchanged parecoxib is detected in urine and only trace amounts in the faeces.
Slovenian: V urinu ni nespremenjenega parekoksiba, v blatu pa se pojavlja le v sledeh.
English: Dynastat works by lowering the amount of these prostaglandins.
Slovenian: Zdravilo Dynastat deluje tako, da zmanjša količino prostaglandinov.
English: In patients with varying degrees of renal impairment administered 20 mg IV Dynastat, parecoxib was rapidly cleared from plasma.
Slovenian: Pri bolnikih z različno stopnjo okvare ledvic, ki so intravensko dobili 20 mg zdravila Dynastat, se je parekoksib hitro očistil iz plazme.
English: 2 ml solvent ampoule contains sodium chloride, hydrochloric acid, sodium hydroxide and water for injection.
Slovenian: 2 ml ampula vehikla vsebuje natrijev klorid, klorovodikovo kislino, natrijev hidroksid in vodo za injekcije.
English: Valdecoxib, but not parecoxib, is extensively partitioned into erythrocytes.
Slovenian: Valdekoksib - ne pa parekoksib - se znatno porazdeli v eritrocite.
English: After IV or IM dosing of parecoxib, the elimination half-life (t1/2) of valdecoxib is about 8 hours.
Slovenian: Po intravenskem ali intramuskularnem vnosu parekoksiba je razpolovni čas izločanja (t1/2) valdekoksiba približno 8 ur.
English: • Use of Sterile Water for Injection for reconstitution is not recommended, as the resulting solution is not isotonic.
Slovenian: • Uporaba sterilne vode za injekcije ni priporočljiva, ker nastala raztopina ni izotonična.
English: The difference in antiplatelet activity between some COX-1 inhibiting NSAIDs and COX-2 selective inhibitors may be of clinical significance in patients at risk of thrombo-embolic reactions.
Slovenian: Razlika v antiagregacijski aktivnosti med nekaterimi nesteroidnimi protivnetnimi zdravili, ki zavirajo COX-1, in selektivnimi zaviralci COX-2 bi lahko bila klinično pomembna pri bolnikih s tveganjem za trombembolične reakcije.
English: Treatment with valdecoxib (40 mg twice daily for 7 days) produced a 3-fold increase in plasma concentrations of dextromethorphan (CYP2D6 substrate).
Slovenian: Zdravljenje z valdekoksibom (40 mg dvakrat na dan 7 dni) je povzročilo 3-kratno povečanje koncentracije dekstrometorfana (substrata CYP2D6) v plazmi.
English: Blood creatinine increased
Slovenian: Zvečanje ravni kreatinina v krvi
English: Some of these cases have occurred without other signs of anaphylaxis.
Slovenian: V nekaterih primerih ni bilo drugih znakov anafilakse.
English: Based on the mechanism of action, the use of NSAIDs, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.
Slovenian: Na osnovi mehanizma delovanja lahko uporaba nesteroidnih protivnetnih zdravil upočasni ali prepreči pretrganje ovarijskih foliklov, kar so povezovali z reverzibilno neplodnostjo pri nekaterih ženskah.
English: In reproduction toxicity tests, the incidence of post-implantation losses, resorptions and foetal body weight retardation occurred at doses not producing maternal toxicity in the rabbit studies.
Slovenian: V preskušanjih reprodukcijske toksičnosti se je incidenca poimplantacijskih izgub, resorpcij in upočasnitve pridobivanja telesne mase ploda pojavila v odmerkih, ki v študijah na kuncih niso bili toksični za samico.
English: Added pain relief compared to opioids alone was shown.
Slovenian: Hkrati je bilo ugotovljeno dodatno olajšanje bolečine v primerjavi s samimi opioidi.
English: In a series of small, multiple dose studies in healthy young and elderly subjects, Dynastat 20 mg or 40 mg twice daily had no effect on platelet aggregation or bleeding compared to placebo.
Slovenian: V več majhnih študijah o večkratnih odmerkih pri zdravih mladih in starejših preskušancih so ugotovili, da 20 ali 40 mg zdravila Dynastat dvakrat na dan v primerjavi s placebom ni vplivalo na agregacijo trombocitov ali krvavitve.
English: Some of these reactions have occurred in patients with a history of allergic-type reactions to sulfonamides (see section 4.3).
Slovenian: Nekaj od teh reakcij se je pojavilo pri bolnikih, ki so imeli reakcije alergijskega tipa na sulfonamide (glejte poglavje 4.3).
English: Patients with a history of sulfonamide allergy may be at greater risk of skin reactions (see section 4.3).
Slovenian: Pri bolnikih z anamnezo alergije na sulfonamid obstaja večje tveganje za pojav kožnih reakcij (glejte poglavje 4.3).
English: Dynastat is contraindicated in the third trimester of pregnancy (see section 4.3).
Slovenian: Zdravilo Dynastat je kontraindicirano v tretjem trimesečju nosečnosti (glejte poglavje 4.3).
English: Uncommon (1/1000 to <1/100)
Slovenian: Občasni ( 1/1.000 do < 1/100)
English: As with all NSAIDs, parecoxib can lead to the onset of new hypertension or worsening of pre-existing hypertension, either of which may contribute to the increased incidence of cardiovascular events.
Slovenian: Kot vsa nesteroidna protivnetna zdravila (NSAID - non-steroidal anti-inflammatory drugs) lahko tudi parekoksib povzroči pojav hipertenzije ali poslabšanje obstoječe hipertenzije; oboje lahko pripomore k večji pojavnosti srčnožilnih dogodkov.
English: Do not use Dynastat if you currently have a gastric or intestinal ulcer or gastrointestinal bleeding
Slovenian: Ne uporabljajte zdravila Dynastat, če imate trenutno razjedo na želodcu ali črevesju ali krvavitev iz prebavil.
English: Parecoxib should be used with caution in patients with hypertension.
Slovenian: Parekoksib je treba pri bolnikih s hipertenzijo uporabljati previdno.
English: History of previous serious allergic drug reaction of any type, especially cutaneous reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme or patients with known hypersensitivity to sulfonamides (see sections 4.4 and 4.8).
Slovenian: Anamneza kakršnekoli resne alergijske reakcije na zdravila, zlasti kožnih reakcij, npr. StevensJohnsonovega sindroma, toksične epidermalne nekrolize, multiformnega eritema ali bolniki z znano preobčutljivostjo na sulfonamide (glejte poglavji 4.4. in 4.8).
English: Treatment of post-operative pain following coronary artery bypass graft (CABG) surgery (see sections 4.8 and 5.1).
Slovenian: Zdravljenje pooperacijske bolečine po CABG (operativna vstavitev presadka koronarnega obvoda) (glejte poglavji 4.8 in 5.1).
English: However, in the repeated dose toxicity studies in dogs and rats, the systemic exposures to valdecoxib (the active metabolite of parecoxib) were approximately 0.8-fold the systemic exposure in elderly human subjects at the maximum recommended therapeutic dose of 80 mg daily.
Slovenian: Vendar je bila sistemska izpostavljenost valdekoksibu (aktivnemu presnovku parekoksiba) v študijah toksičnosti ponavljajočih se odmerkov pri psih in podganah približno 0,8-kratnik sistemske izpostavljenosti pri starejših osebah pri največjem priporočenem terapevtskem odmerku 80 mg na dan.
English: A significantly (p=0.033) greater incidence of events in the cardiovascular/thromboembolic category was detected in the parecoxib/valdecoxib treatment group (2.0%) compared to the placebo/placebo treatment group (0.5%).
Slovenian: Znatno večjo pojavnost (p = 0,033) dogodkov v kategoriji kardiovaskularnih/trombemboličnih obolenj so odkrili pri skupini, ki je bila zdravljena s parekoksibom/valdekoksibom (2,0 %), v primerjavi s skupino, ki je prejemala placebo/placebo
English: However, the reported rate of serious skin events appears to be greater for valdecoxib (the active metabolite of parecoxib) as compared to other COX-2 selective inhibitors.
Slovenian: Toda, kot kaže, je opisani delež resnih kožnih reakcij večji pri valdekoksibu (aktivnem presnovku parekoksiba) kot pri drugih selektivnih zaviralcih COX-2.
English: The IV line must be adequately flushed prior to and after Dynastat injection with a solution of known compatibility (see section 6.6).
Slovenian: Pred injiciranjem zdravila Dynastat in po njem je treba intravensko pot temeljito sprati z znano kompatibilno raztopino (glejte poglavje 6.6).
English: This medicine does not require any special storage conditions prior to reconstitution.
Slovenian: Za shranjevanje zdravila pred rekonstitucijo niso potrebna posebna navodila.
English: In those patients where the same IV line is to be used to inject another medicinal product, the line must be adequately flushed prior to and after Dynastat injection with a solution of known compatibility.
Slovenian: Če se pri bolniku uporablja ista intravenska pot za injiciranje drugih zdravil, je treba pot pred injiciranjem zdravila Dynastat in po njem ustrezno sprati z raztopino, za katero je znano, da je kompatibilna.
English: In women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of NSAIDs, including Dynastat should be considered.
Slovenian: Pri ženskah, ki imajo težave z zanositvijo ali pri katerih potekajo preiskave zaradi neplodnosti, je smiselno razmisliti o prekinitvi zdravljenja z nesteroidnimi protivnetnimi zdravili, vključno z zdravilom Dynastat.
English: Circulatory collapse, congestive heart failure, tachycardia
Slovenian: Cirkulatorni kolaps, kongestivno srčno popuščanje, tahikardija
English: Use of water for injection is not recommended, as the resulting solution is not isotonic.
Slovenian: Uporaba vode za injekcije ni priporočljiva, ker nastala raztopina ni izotonična.
English: ▪ NSAIDs, including Dynastat, may make it more difficult to become pregnant.
Slovenian: • Zaradi nesteroidnih protivnetnih zdravil, vključno z zdravilom Dynastat, je morda težje zanositi.
English: Plasma clearance (CLp) for valdecoxib is about 6 l/hr.
Slovenian: Plazemski očistek (CLp) valdekoksiba je približno 6 l/uro.
English: The NSAIDs class is also associated with increased GI complications when coadministered with glucocorticoids, selective serotonin reuptake inhibitors, other antiplatelet drugs, other NSAIDs or patients ingesting alcohol.
Slovenian: Ta razred NSAID je povezan s pogostejšimi gastrointestinalnimi zapleti tudi pri sočasni uporabi z glukokortikoidi, selektivnimi zaviralci ponovnega privzema serotonina, drugimi antiagregacijskimi zdravili, drugimi NSAID ali pri bolnikih, ki uživajo alkohol.
English: Coadministration of valdecoxib and lithium produced significant decreases in lithium serum clearance (25%) and renal clearance (30%) with a 34% higher serum exposure compared to lithium alone.
Slovenian: Sočasna uporaba valdekoksiba in litija je povzročila pomembno zmanjšanje serumskega (25 %) in ledvičnega očistka (30 %) litija, tako da se je serumska izpostavljenost v primerjavi s samim litijem povečala za 34 %.
English: Dissolve the powder completely using a gentle swirling motion and inspect the reconstituted product before use.
Slovenian: Prašek popolnoma raztopite tako, da vialo previdno obračate; pred uporabo rekonstituirano raztopino preglejte.
English: For storage conditions of the reconstituted medicinal product see section 6.3.
Slovenian: Za pogoje shranjevanja po rekonstituciji zdravila glejte poglavje 6.3.
English: Because renal elimination of valdecoxib is not important to its disposition, no changes in valdecoxib clearance were found even in patients with severe renal impairment or in patients undergoing dialysis (see section 4.2).
Slovenian: Ker izločanje valdekoksiba skozi ledvice ni pomembno za njegovo odstranjevanje, sprememb očistka valdekoksiba niso ugotovili niti pri bolnikih s hudo ledvično okvaro ali na dializi (glejte poglavje 4.2).
English: Also contains disodium hydrogen phosphate, phosphoric acid and sodium hydroxide.
Slovenian: Vsebuje tudi natrijev hidrogenfosfat, fosforjevo kislino in natrijev hidroksid.
English: In humans, studies demonstrated that valdecoxib metabolism is predominantly mediated via CYP3A4 and 2C9 isozymes.
Slovenian: Študije so pokazale, da presnova valdekoksiba pri ljudeh poteka pretežno s pomočjo izoencimov CYP3A4 in 2C9.
English: There is further increase in the risk of gastrointestinal adverse effects (gastrointestinal ulceration or other gastrointestinal complications), when parecoxib is taken concomitantly with acetylsalicylic acid (even at low doses).
Slovenian: Tveganje za neželene učinke v prebavilih (razjeda v prebavilih ali drugi gastrointestinalni zapleti), se še dodatno poveča, kadar se parekoksib uporablja sočasno z acetilsalicilno kislino (celo pri majhnih odmerkih).
English: Precipitation may occur when Dynastat is combined in solution with other medicinal products and therefore Dynastat must not be mixed with any other medicinal product, either during reconstitution or injection.
Slovenian: Če zdravilo Dynastat kombiniramo v raztopini z drugimi zdravili, lahko pride do precipitacije, zato zdravila Dynastat ne smemo mešati z drugimi zdravili niti med rekonstitucijo niti med injiciranjem.
English: Dynastat should not be injected into an IV line delivering any other medicinal product.
Slovenian: Zdravila Dynastat ne smemo injicirati v intravensko pot, v katero apliciramo druga zdravila.
English: The most serious reactions occur uncommonly to rarely, and include cardiovascular events such as myocardial infarction and severe hypotension, as well as hypersensitivity events such as anaphylaxis, angioedema and severe skin reactions.
Slovenian: Večina resnih neželenih učinkov se pojavi občasno do redko in vključujejo srčnožilne dogodke, npr. miokardni infarkt in hudo hipotenzijo, ter preobčutljivostne reakcije, kot so anafilaktične reakcije, angioedem in hude kožne reakcije.
English: Dynastat should be used with caution in patients with moderate hepatic impairment (Child-Pugh score 7-9) (see section 4.2).
Slovenian: Zdravilo Dynastat je treba uporabljati previdno pri bolnikih z zmerno okvaro jeter (ocena od 7 do 9 po Child-Pughu) (glejte poglavje 4.2).
English: Dynastat is available in packs containing 10 vials.
Slovenian: Zdravilo Dynastat je na voljo v naslednjem pakiranju: škatla z 10 vialami.
English: Therefore, caution should be observed when administering Dynastat with medicinal products known to be substrates of CYP2C19 (e.g. phenytoin, diazepam, or imipramine).
Slovenian: Zato je potrebna previdnost med uporabo zdravila Dynastat z zdravili, za katera je znano, da so substrati CYP2C19 (npr. fenitoin, diazepam ali imipramin).
English: Dynastat may mask fever and other signs of inflammation (see section 5.1).
Slovenian: Zdravilo Dynastat lahko prikrije zvišano telesno temperaturo in druge znake vnetja (glejte poglavje 5.1).
English: Marketing Authorisation Holder: Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgium
Slovenian: Imetnik dovoljenja za promet: Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgija
English: Adverse Drug Reaction Frequency Very Common
Slovenian: Pogostnost neželenih učinkov Zelo pogosti
English: Reconstitution solvents This medicinal product must not be mixed with other medicinal products.
Slovenian: Zdravila ne smemo mešati z drugimi zdravili.
English: In two pharmacokinetic interaction studies in rheumatoid arthritis patients receiving a stable weekly methotrexate dose (5-20 mg/week, as a single oral or intramuscular dose), orally administered valdecoxib (10 mg twice daily or 40 mg twice daily) had little or no effect on the steady-state plasma concentrations of methotrexate.
Slovenian: V dveh farmakokinetičnih študijah o medsebojnem delovanju pri bolnikih z revmatoidnim artritisom, ki so enkrat na teden dobivali stabilen odmerek metotreksata (5-20 mg/teden kot enkratni peroralni ali intramuskularni odmerek), je peroralno dan valdekoksib (10 mg dvakrat na dan ali 40 mg dvakrat na dan) malo ali pa sploh ni vplival na koncentracijo metotreksata v plazmi v stanju dinamičnega ravnovesja.
English: Effects of other medicinal products on the pharmacokinetics of parecoxib (or its active metabolite valdecoxib)
Slovenian: Vpliv drugih zdravil na farmakokinetiko parekoksiba (ali njegovega aktivnega presnovka valdekoksiba)