FrancophonIA/ELRC3.0 huggingface dataset:
English: Other substitutions yielded a fold change of 5-10 (G190S (5.7); K103N/P225H (7.9), V108I/Y181C (6.9), Y181V (5.1)).
Slovenian: Druge substitucije so povzročile od 5- do 10-kratno spremembo (G190S (5,7-kratno), K103N/P225H (7,9-kratno), V108I/Y181C (6,9-kratno), Y181V (5,1-kratno)).
English: Exclusionary NNRTI substitutions were those listed above (DRIVE-FORWARD and DRIVE-AHEAD), with the exception of substitutions RT K103N, G190A and Y181C (accepted in DRIVE-SHIFT).
Slovenian: Nevključene z NNRTI povezane substitucije so navedene zgoraj (preskušanji DRIVE-FORWARD in DRIVE-AHEAD) z izjemo substitucij RT K103N, G190A in Y181C (vključene v preskušanje DRIVE-SHIFT).
English: Animal studies do not indicate harmful effects of doravirine, lamivudine, or tenofovir disoproxil on fertility at exposure levels higher than the exposure in humans at the recommended clinical dose (see section 5.3).
Slovenian: Rezultati študij na živalih niso pokazali škodljivih vplivov doravirina, lamivudina ali dizoproksiltenofovirata na plodnost ob izpostavljenostih, ki so bile večje od izpostavljenosti pri človeku med uporabo priporočenega kliničnega odmerka (glejte poglavje 5.3).
English: Expected:  rosuvastatin  simvastatin
Slovenian: Pričakovano:  rosuvastatin  simvastatin
English: Bone abnormalities (infrequently contributing to fractures) may be associated with proximal renal tubulopathy.
Slovenian: Kostne nepravilnosti (ki v redkih primerih pripomorejo k zlomom) so lahko povezane s proksimalno ledvično tubulopatijo.
English: Following oral dosing, peak plasma concentrations are achieved 2 hours after dosing.
Slovenian: Po peroralni uporabi je bila največja koncentracija v plazmi dosežena v 2 urah po odmerku.
English: Caution should be given to prescribing doravirine with medicinal products that may reduce the exposure of doravirine (see sections 4.3 and 4.5).
Slovenian: V primeru predpisovanja doravirina z zdravili, ki lahko zmanjšajo izpostavljenost doravirinu, je potrebna previdnost (glejte poglavji 4.3 in 4.5).
English: If you forget to take Delstrigo
Slovenian: Če ste pozabili vzeti zdravilo Delstrigo
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Pri z virusom HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo se lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - combination antiretroviral therapy) pojavi vnetna reakcija na asimptomatične ali rezidualne oportunistične okužbe.
English: Lamivudine was not mutagenic in a microbial mutagenicity assay, in an in vitro cell transformation assay, in a rat micronucleus test, in a rat bone marrow cytogenetic assay, and in an assay for unscheduled DNA synthesis in rat liver.
Slovenian: Lamivudin ni bil mutagen v preizkusu mutagenosti pri mikrobih, v preizkusu transformacije celic in vitro, v mikrojedrnem preizkusu pri podganah, v citogenetskem preizkusu na kostnem mozgu podgan in v preizkusu nenačrtne sinteze DNA v jetrih podgan.
English: Therefore, cross-resistance among these NRTIs may occur in patients whose virus harbours the K65R substitution.
Slovenian: Zato se lahko pri bolnikih, katerih virus ima substitucijo K65R, pojavi navzkrižna odpornost med temi NRTI.
English: In clinical trials in HIV-1 infected adults, tenofovir disoproxil was associated with slightly greater decreases in bone mineral density (BMD) and increases in biochemical markers of bone metabolism, suggesting increased bone turnover relative to comparators.
Slovenian: V kliničnih preskušanjih pri odraslih, okuženih s HIV-1, je uporabo dizoproksiltenofovirata spremljalo nekoliko večje zmanjšanje mineralne gostote kosti (MKG) in povečanje biokemičnih označevalcev kostne presnove, kar nakazuje večjo kostno premeno v primerjavi s primerjalnimi učinkovinami.
English: Therefore, caution should be used when co-administering doravirine with medicinal products that are sensitive CYP3A substrates that also have a narrow therapeutic window (e.g., tacrolimus and sirolimus).
Slovenian: Zato je med sočasno uporabo doravirina in zdravil, ki so občutljivi substrati CYP3A in imajo tudi ozko terapevtsko okno (npr. takrolimus in sirolimus), potrebna previdnost.
English: Refer to Resistance section for NNRTI substitutions that were part of exclusion criteria.
Slovenian: Za informacije o substitucijah, povezanih z NNRTI, ki so bile del meril za nevključitev, glejte poglavje Odpornost.
English: • decreased number of red blood cells in your blood (anaemia)
Slovenian: • zmanjšanje števila rdečih krvnih celic (anemija)
English: Delstrigo contains doravirine, lamivudine, and tenofovir disoproxil, therefore any interactions identified for these individually are relevant to Delstrigo and are presented in Table 1.
Slovenian: Zdravilo Delstrigo vsebuje doravirin, lamivudin in dizoproksiltenofovirat, zato so zanj pomembna vsa medsebojna delovanja, ugotovljena za vsako od teh učinkovin posamezno; prikazana so v preglednici 1.
English: New or worsening kidney problems, including kidney failure This can happen in some people who take Delstrigo.
Slovenian: Novonastale težave z ledvicami, vključno z odpovedjo ledvic, ali njihovo poslabšanje Te se lahko pojavijo pri nekaterih ljudeh, ki jemljejo zdravilo Delstrigo.
English: Laboratory strains of HIV-1 harbouring the common NNRTI-associated mutations K103N, Y181C, or K103N/Y181C substitutions in RT exhibit less than a 3-fold decrease in susceptibility to doravirine compared to wild-type virus when evaluated in the presence of 100 % normal human serum.
Slovenian: Laboratorijskim sevom HIV-1, ki imajo v RT pogoste z NNRTI povezane mutacije, substitucije K103N, Y181C K103N/Y181C, se občutljivost za doravirin zmanjša manj kot 3-krat v primerjavi z divjim tipom virusa (ocenjeno v prisotnosti 100 % normalnega človeškega seruma).
English: • nafcillin (a medicine to treat some bacterial infections)
Slovenian: • nafcilin (zdravilo za zdravljenje nekaterih bakterijskih okužb),
English: canagliflozin liraglutide sitagliptin
Slovenian: kanagliflozin liraglutid sitagliptin
English: Expected:  canagliflozin  liraglutide  sitagliptin
Slovenian: Pričakovano:  kanagliflozin  liraglutid  sitagliptin
English: Delstrigo should not be initiated in patients with estimated CrCl < 50 mL/min (see sections 4.4 and 5.2).
Slovenian: Zdravila Delstrigo se ne sme uvesti bolnikom, ki imajo ocenjeni očistek kreatinina < 50 ml/min (glejte poglavji 4.4 in 5.2).
English: • sofosbuvir/velpatasvir (medicines used to treat hepatitis C infection)
Slovenian: • sofosbuvir/velpatasvir (zdravili za zdravljenje okužbe s hepatitisom C),
English: Delstrigo should be avoided with concurrent or recent use of nephrotoxic medicinal products (e.g., high-dose or multiple nonsteroidal anti-inflammatory medicinal products [NSAIDs]) (see section 4.5).
Slovenian: Zdravilu Delstrigo se je treba izogniti, če bolnik trenutno uporablja ali je nedavno uporabljal kakšna nefrotoksična zdravila (npr. velike odmerke ali več različnih nesteroidnih protivnetnih zdravil [NSAID - nonsteroidal anti-inflammatory medicinal products]) (glejte poglavje 4.5).
English: If you stop taking Delstrigo
Slovenian: Če ste prenehali jemati zdravilo Delstrigo
English: Psychiatric disorders Common abnormal dreams, insomnia
Slovenian: Psihiatrične motnje Pogosti nenormalne sanje, nespečnost
English: The pharmacokinetics of tenofovir following a 245 mg dose of tenofovir disoproxil have been studied in healthy subjects with moderate to severe hepatic impairment.
Slovenian: Dizoproksiltenofovirat Farmakokinetiko tenofovirja po odmerku 245 mg dizoproksiltenofovirata so raziskali pri zdravih osebah z zmerno do hudo okvaro jeter.
English: Pharmacokinetic parameters were not altered by diminishing hepatic function.
Slovenian: Zmanjšanje delovanja jeter ni spremenilo farmakokinetičnih parametrov.
English: Delstrigo is indicated for the treatment of adults infected with HIV-1 without past or present evidence of resistance to the NNRTI class, lamivudine, or tenofovir (see sections 4.4 and 5.1).
Slovenian: Zdravilo Delstrigo je indicirano za zdravljenje odraslih, okuženih s HIV-1, ki nimajo in tudi nikoli niso imeli znakov odpornosti proti nenukleozidnim zaviralcem reverzne transkriptaze (NNRTI), lamivudinu ali tenofovirju (glejte poglavji 4.4 in 5.1).
English: It is preferable to avoid the use of Delstrigo during pregnancy.
Slovenian: Iz previdnosti se je uporabi zdravila Delstrigo med nosečnostjo bolje izogniti.
English: After multiple-dose oral administration of lamivudine 300 mg once daily for 7 days to 60 healthy subjects, steady-state Cmax (Cmax,ss) was 2.04 ± 0.54 mcg per mL (mean ± SD) and the 24-hour steady-state AUC (AUC24,ss) was 8.87 ± 1.83 mcg•hour per mL.
Slovenian: Po uporabi večkratnih peroralnih odmerkov 300 mg lamivudina enkrat na dan 7 dni pri 60 zdravih osebah je bila Cmax v stanju dinamičnega ravnovesja (Cmax,ss) 2,04 ± 0,54 mikrograma na ml (povprečje ± standardni odklon), in 24-urna AUC v stanju dinamičnega ravnovesja (AUC24,ss) 8,87 ± 1,83 mikrograma•ura na ml. Vezava na beljakovine v plazmi je majhna.
English: • thioridazine (a medicine to treat psychiatric conditions such as schizophrenia)
Slovenian: • tioridazin (zdravilo za zdravljenje psihiatričnih motenj, na primer shizofrenije).
English: Subjects must have been virologically suppressed (HIV-1 RNA < 40 copies/mL) on their baseline regimen for at least 6 months prior to trial entry, with no history of virologic failure, and a documented absence of RT substitutions conferring resistance to doravirine, lamivudine and tenofovir (see section, Resistance).
Slovenian: Preiskovanci so morali biti med uporabo svoje izhodiščne sheme virološko suprimirani (HIV-1 RNA < 40 kopij/ml) vsaj 6 mesecev pred vključitvijo v preskušanje, v anamnezi niso smeli imeti virološkega neuspeha in so morali imeti potrjeno odsotnost substitucij RT, ki povzročajo odpornost proti doravirinu, lamivudinu in tenofovirju (glejte poglavje Odpornost).
English: Studies in pregnant rats and rabbits showed that doravirine is transferred to the foetus through the placenta, with foetal plasma concentrations of up to 40 % (rabbits) and 52 % (rats) that of maternal concentrations observed on gestation Day 20.
Slovenian: Rezultati študije pri brejih podganah in kunkah so pokazali, da doravirin prehaja v plod skozi placento; 20. dan gestacije je bila koncentracija v plodovi plazmi do 40 % (kunci) oz. 52 % (podgane) koncentracije pri materi.
English: Effects of doravirine, lamivudine, and tenofovir disoproxil on other medicinal products Doravirine
Slovenian: Vpliv doravirina, lamivudina in dizoproksiltenofovirata na druga zdravila
English: Lamivudine Lamivudine did not affect male or female fertility in rats.
Slovenian: Lamivudin Lamivudin ni vplival na plodnost podganjih samcev in samic.
English: • inflammation of the skin due to allergy, redness on the cheeks, nose, chin or forehead, bumps or pimples on the face, swelling of the face, lips, tongue or throat
Slovenian: • vnetje kože zaradi alergije, pordelost lic, nosu, brade ali čela, bulice ali mozolji na obrazu,
English: Doravirine does not inhibit the human cellular DNA polymerases α, ß, and mitochondrial DNA polymerase γ.
Slovenian: Doravirin ne zavira človeških celičnih DNA polimeraz α in β ali mitohondrijske DNA polimeraze γ.
English: • mitotane
Slovenian: • mitotan,
English: • ledipasvir/sofosbuvir (medicines used to treat hepatitis C infection)
Slovenian: • ledipasvir/sofosbuvir (zdravili za zdravljenje okužbe s hepatitisom C),
English: • feeling weak, general feeling of being unwell
Slovenian: • občutek šibkosti, splošno slabo počutje
English: If the patient misses a dose of Delstrigo within 12 hours of the time it is usually taken, the patient should take Delstrigo as soon as possible and resume the normal dosing schedule.
Slovenian: Če bolnik izpusti odmerek zdravila Delstrigo in je od časa, ko ga vzame po navadi, minilo manj kot 12 ur, mora zdravilo Delstrigo vzeti čim prej in nato nadaljevati jemanje po običajnem urniku.
English: Delstrigo is a complete regimen taken as a single tablet for the treatment of HIV infection.
Slovenian: Zdravilo Delstrigo je popolna shema za zdravljenje okužbe s HIV v eni sami tableti.
English: The antiviral activity of tenofovir against laboratory and clinical isolates of HIV-1 was assessed in T lymphoblastoid cell lines, primary monocyte/macrophage cells and peripheral blood lymphocytes.
Slovenian: Protivirusno aktivnost tenofovirja proti laboratorijskim in kliničnim izolatom HIV-1 so ocenili v celičnih linijah limfoblastoidnih celic T, predvsem v monocitih/makrofagih in v limfocitih periferne krvi.
English: Tenofovir disoproxil was mutagenic in the in vitro mouse lymphoma assay and negative in an in vitro bacterial mutagenicity test (Ames test).
Slovenian: Dizoproksiltenofovirat je bil mutagen v preizkusu mišjega limfoma in vitro, negativen pa je bil v testu mutagenosti pri bakterijah (Amesov test) in vitro.
English: Co-administration with the moderate CYP3A inducer rifabutin decreased doravirine concentrations (see Table 1).
Slovenian: Sočasna uporaba z zmernim induktorjem CYP3A rifabutinom je zmanjšala koncentracijo doravirina (glejte preglednico 1).
English: If a patient misses a dose of Delstrigo by more than 12 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time.
Slovenian: Če bolnik izpusti odmerek zdravila Delstrigo in je od časa, ko ga vzame po navadi, minilo več kot 12 ur, naj ne vzame izpuščenega odmerka, temveč naj namesto tega vzame naslednji odmerek ob rednem predvidenem času.
English: Film-coated tablets 30 film-coated tablets 90 (3 bottles of 30) film-coated tablets
Slovenian: filmsko obložene tablete 30 filmsko obloženih tablet 90 (3 plastenke po 30) filmsko obloženih tablet
English: Autoimmune disorders (such as Graves' disease, autoimmune hepatitis, polymyositis, and GuillainBarré syndrome) have also been reported to occur in the setting of immune reactivation; however, the time to onset is more variable and can occur many months after initiation of treatment.
Slovenian: V okviru imunske obnove so poročali tudi o pojavu avtoimunskih bolezni (npr. Gravesove bolezni, avtoimunski hepatitis, polimiozitisa in Guillan-Barréjevega sindroma), toda čas do začetka njihovega pojava je bolj spremenljiv in pojavijo se lahko več mesecev po uvedbi zdravljenja.
English: Immune reactivation syndrome
Slovenian: Vnetni sindrom imunske obnove
English: • increased levels of creatine phosphokinase
Slovenian: • zvišanje kreatin-fosfokinaze
English: None of the 24 subjects (11 in the immediate switch group, 13 in the delayed switch group) with baseline NNRTI mutations (RT K103N, G190A, or Y181C) experienced virologic failure through Week 48, or at time of discontinuation.
Slovenian: Pri nobenem od 24 preiskovancev (11 v skupini s takojšnim prehodom, 13 v skupini z odloženim prehodom), ki so imeli v izhodišču z NNRTI povezane mutacije (RT K103N, G190A ali Y181C), se do 48. tedna oz. ob času prenehanja ni pojavil virološki neuspeh.
English: Doravirine steady state pharmacokinetics following administration of 100 mg once daily to HIV-1 infected subjects, based on a population pharmacokinetics analysis are provided below.
Slovenian: Spodaj je prikazana farmakokinetika doravirina v stanju dinamičnega ravnovesja po uporabi 100 mg enkrat na dan pri preiskovancih, okuženih s HIV-1, na podlagi populacijske farmakokinetične analize.
English: • Keep the bottle tightly closed in order to protect from moisture.
Slovenian: • Plastenko shranjujte dobro zaprto za zagotovitev zaščite pred vlago.
English: Doravirine is primarily metabolised and eliminated by the liver.
Slovenian: Doravirin se v prvi vrsti presnovi in odstrani v jetrih.
English: < 200 cells/mm
Slovenian: < 200 celic/mm
English: 12 hours, skip the dose you missed and take the next one at the usual time.
Slovenian: Toda če je do vašega naslednjega odmerka manj kot 12 ur, pozabljeni odmerek izpustite in vzemite naslednjega ob običajnem času.
English: HIV-1 isolates with the K65R substitution also showed reduced susceptibility to emtricitabine and lamivudine.
Slovenian: Izolati HIV-1 s substitucijo K65R so bili tudi manj občutljivi na emtricitabin in lamivudin.
English: The clinically relevant effects noted were a reduction in red blood cell count and neutropenia.
Slovenian: Opažena klinično pomembna učinka sta bila zmanjšanje števila eritrocitov in nevtropenija.
English: Rare hypomagnesaemia, lactic acidosis*
Slovenian: Redki hipomagneziemija, laktacidoza*
English: HIV-1 isolates selected by tenofovir expressed a K65R substitution in HIV-1 RT and showed a 2-4 fold reduction in susceptibility to tenofovir.
Slovenian: Izolati HIV-1, selekcionirani s tenofovirjem, so imeli v RT HIV-1 izraženo substitucijo K65R in so bili od 2- do 4-krat manj občutljivi za tenofovir.
English: Keep the bottle tightly closed in order to protect from moisture.
Slovenian: Plastenko shranjujte dobro zaprto za zagotovitev zaščite pred vlago.
English: The median EC50 values of lamivudine were 60 nM (range: 20 to 70 nM), 35 nM (range: 30 to 40 nM), 30 nM (range: 20 to 90 nM), 20 nM (range: 3 to 40 nM), 30 nM (range: 1 to 60 nM), 30 nM (range: 20 to 70 nM), 30 nM (range: 3 to 70 nM), and 30 nM (range: 20 to 90 nM) against HIV-1 clades A-G and group O viruses (n = 3 except n = 2 for clade B) respectively.
Slovenian: Mediana vrednost EC50 lamivudina proti HIV-1 kladov od A do G in virusom skupine O (n = 3 razen n = 2 za klad B) je bila 60 nM (razpon: 20-70 nM), 35 nM (razpon: 30-40 nM), 30 nM (razpon: 20-90 nM), 20 nM (razpon: od 3-40 nM ), 30 nM (razpon: od 1-60 nM), 30 nM (razpon: 20-70 nM), 30 nM (razpon: 3-70 nM) in 30 nM (razpon: 20-90 nM), v tem zaporedju.
English: This is because it has not been studied in pregnancy and it is not known if Delstrigo will harm your baby while you are pregnant.
Slovenian: Uporaba zdravila Delstrigo med nosečnostjo namreč ni raziskana in tako ni znano, ali zdravilo Delstrigo med nosečnostjo škoduje otroku.
English: Persistent or worsening bone pain, pain in extremities, fractures, and/or muscular pain or weakness may be manifestations of proximal renal tubulopathy and should prompt an evaluation of renal function in at risk patients.
Slovenian: Stalne kostne bolečine ali njihovo poslabšanje, bolečine v okončinah, zlomi in/ali boleče ali šibke mišice so lahko znaki proksimalne ledvične tubulopatije; če se pojavijo, je treba pri bolnikih s tveganjem nemudoma oceniti delovanje ledvic.
English: Expected:  doravirine
Slovenian: Pričakovano:  doravirin
English: Doravirine pharmacokinetics are similar in healthy subjects and HIV-1-infected subjects.
Slovenian: Farmakokinetika doravirina je pri zdravih osebah in preiskovancih, okuženih s HIV-1, podobna.
English: Lamivudine and tenofovir disoproxil are primarily excreted by the kidney.
Slovenian: Lamivudin in dizoproksiltenofovirat se izločata predvsem skozi ledvice.
English: • telotristat ethyl (a medicine to treat diarrhea in people with carcinoid syndrome)
Slovenian: • etiltelotristat (zdravilo za zdravljenje driske pri osebah s karcinoidnim sindromom),
English: MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. PROIZVAJALEC (PROIZVAJALCI), ODGOVOREN (ODGOVORNI) ZA SPROŠČANJE SERIJ
English: At baseline, the median age of subjects was 31 years (range 18-70 years), 85 % were male, 52 % were non-white, 3 % had hepatitis B or C co-infection, 14 % had a history of AIDS, 21 % had HIV-1 RNA > 100,000 copies per mL, and 12 % had CD4
Slovenian: V izhodišču je bila mediana starost preiskovancev 31 let (razpon: od 18 do 70 let), 85 % je bilo moških, 52 % je bilo nebelcev, 3 % so imeli sočasno okužbo z virusom hepatitisa B in/ali C, 14 % je imelo v anamnezi aids, 21 % je imelo HIV-1 RNA > 100.000 kopij/ml in 12 % jih je imelo število celic T CD4 < 200 celic/mm
English: Compared with subjects with normal renal function, the mean (% CV) tenofovir exposure increased from 2,185 (12 %) ng·h/mL in subjects with CrCl > 80 mL/min to respectively 3,064 (30 %) ng·h/mL, 6,009 (42 %) ng·h/mL and 15,985 (45 %) ng·h/mL in subjects with mild, moderate, and severe renal impairment.
Slovenian: V primerjavi s preiskovanci z normalnim delovanjem ledvic se je povprečna (% KV) izpostavljenost tenofovirju od 2.185 (12 %) ng·h/ml pri preiskovancih z očistkom kreatinina > 80 ml/min pri preiskovancih z blago okvaro povečala na 3.064 ng·h/ml (30 %), pri tistih z zmerno okvaro na 6.009 ng·h/ml (42 %) in tistih s hudo okvaro ledvic na 15.985 ng·h/ml (45 %).
English: Baseline regimen = ritonavir or cobicistat-boosted PI (specifically atazanavir, darunavir, or lopinavir), or cobicistat-boosted elvitegravir, or NNRTI (specifically efavirenz, nevirapine, or rilpivirine), each administered with two NRTIs.
Slovenian: Izhodiščna shema = zaviralec proteaz (specifično atazanavir, darunavir ali lopinavir), ojačen z ritonavirjem ali kobicistatom, ali elvitegravir, ojačen s kobicistatom, ali NNRTI (specifično efavirenz, nevirapin ali rilpivirin), vsi uporabljeni z dvema NRTI.
English: Oral Contraceptives
Slovenian: Peroralni kontraceptivi
English: Administration of lamivudine in animal toxicity studies at high doses was not associated with any major organ toxicity.
Slovenian: Uporaba velikih odmerkov lamivudina v študijah toksičnosti na živalih ni bila povezana s toksičnimi učinki na katerega od pomembnih organov.
English: HIV-1 isolates from patients (n = 20) whose HIV-1 expressed a mean of 3 zidovudine associated RT amino acid substitutions (M41L, D67N, K70R, L210W, T215Y/F, or K219Q/E/N) showed a 3.1-fold decrease in the susceptibility to tenofovir.
Slovenian: Izolati HIV-1 bolnikov (n = 20), katerih HIV-1 je imel izražene povprečno 3 z zidovudinom povezane aminokislinske substitucije RT (M41L, D67N, K70R, L210W, T215Y/F ali K219Q/E/N), so imeli 3,1-krat manjšo občutljivost za tenofovir.
English: Refill your prescription or talk to your doctor before your Delstrigo is all gone.
Slovenian: Zdravilo prevzemite v lekarni ali se posvetujte z zdravnikom, še preden vam zmanjka zdravila Delstrigo.
English: In DRIVE-FORWARD, 766 subjects were randomised and received at least 1 dose of either doravirine 100 mg or darunavir + ritonavir 800+100 mg once daily, each in combination with emtricitabine/tenofovir disoproxil (FTC/TDF) or abacavir/lamivudine (ABC/3TC) selected by the investigator.
Slovenian: V preskušanju DRIVE-FORWARD je bilo randomiziranih 766 preiskovancev in prejeli so vsaj 1 odmerek bodisi 100 mg doravirina bodisi kombinacije darunavirja + ritonavirja 800 + 100 mg enkrat na dan, oboje v kombinaciji z emtricitabinom/dizoproksiltenofoviratom (FTC/TDF) ali z abakavirjem/lamivudinom (ABC/3TC) po izbiri raziskovalca.
English: If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Slovenian: Če imate kakršna koli dodatna vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Mean CD4 change from baseline
Slovenian: Povprečna sprememba CD4 od izhodišča
English: Uncommon myalgia, arthralgia, rhabdomyolysis* muscular weakness*
Slovenian: Občasni mialgija, artralgija, rabdomioliza* †, šibkost mišic*
English: The K70E substitution selected clinically by tenofovir disoproxil results in reduced susceptibility to abacavir, didanosine, emtricitabine, lamivudine, and tenofovir.
Slovenian: Substitucija K70E, klinično selekcionirana z dizoproksiltenofoviratom, zmanjša občutljivost za abakavir, didanozin, emtricitabin, lamivudin in tenofovir.
English: • decreased levels of magnesium
Slovenian: • znižanje koncentracije magnezija
English: This adverse reaction may occur as a consequence of proximal renal tubulopathy.
Slovenian: Ta neželeni učinek se lahko pojavi kot posledica proksimalne ledvične tubulopatije.
English: Joint or muscle pain or muscle weakness may also occur.
Slovenian: Pojavijo se lahko tudi bolečine v sklepih ali mišicah ali šibkost mišic.
English: Medicinal Product by Therapeutic Area
Slovenian: Zdravila po terapevtskih področjih
English: • decreased number of white blood cells in your blood (neutropenia)
Slovenian: • zmanjšanje števila belih krvnih celic (nevtropenija)