FrancophonIA/ELRC3.0 huggingface dataset:
English: Each vial is for single use and should be used immediately.
Danish: Hvert hætteglas er til engangsbrug og skal anvendes straks.
English: In the pivotal SCCHN studies patients who experienced complicated neutropenia (including prolonged neutropenia, febrile neutropenia, or infection), it was recommended to use G-CSF to provide prophylactic coverage (eg, day 6-15) in all subsequent cycles.
Danish: Til patienter, som i SCCHN pivotalstudiet udviklede kompliceret neutropeni (inklusive prolongeret neutropeni, febril neutropeni eller infektion), blev G-CSF anbefalet som profylakse (f.eks. dag 6-15) i alle efterfølgende cyklusser.
English: • Mitoxantrone 12 mg/m2 every 3 weeks for 10 cycles.
Danish: • Mitoxantrone 12 mg/m2 hver 3. uge i 10 behandlingsrunder.
English: This leaflet was last revised in {MM/YYYY}
Danish: Denne indlægsseddel blev senest ændret
English: For combination with capecitabine, the most frequent treatment-related undesirable effects (≥ 5%) reported in a phase III study in breast cancer patients failing anthracycline treatment are presented (see capecitabine summary of product characteristics).
Danish: I kombination med capecitabin er de mest almindelige behandlingsrelaterede bivirkninger (≥ 5 %) medtaget, som blev rapporteret i et fase III-studie med brystkræftpatienter, hvor anthracyclinbehandling ikke havde haft effekt (se: produktresuméet for capecitabin).
English: In first-line treatment, docetaxel 75 mg/m2 is given in combination therapy with doxorubicin (50 mg/m2).
Danish: Som førstebehandling indgives 75 mg/m2 doxetaxel i kombinationsbehandling med doxorubicin (50 mg/m2).
English: Time to progressive disease was superior in the docetaxel + capecitabine combination arm (p < 0.0001).
Danish: Tid indtil progressiv sygdom var længere i kombinationsarmen med Xeloda + docetaxel (p < 0,0001).
English: Polysorbate 80
Danish: 6.1 Hjælpestoffer Polysorbat 80
English: The concomitant use of docetaxel with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin and voriconazole) should be avoided (see section 4.5).
Danish: Samtidig anvendelse af docetaxel og potente CYP3A4-hæmmere (f.eks. ketoconazol, itraconazol, clarithromycin, indinavir, nefazodon, nelfinavir, ritonavir, saquinavir, telithromycin og voriconazol) bør undgås (se pkt.
English: Docetaxel pharmacokinetics in the presence of prednisone was studied in patients with metastatic prostate cancer.
Danish: Docetaxels farmakokinetik under tilstedeværelse af prednison blev undersøgt hos patienter med metastatisk prostatakræft.
English: Excipients: polysorbate 80, ethanol anhydrous (see leaflet for further information), anhydrous citric acid (for pH adjustment).
Danish: Hjælpestoffer: polysorbat 80, ethanol vandfri (se indlægsseddel for yderligere information), citronsyre vandfri (til pH-justering).
English: Very rare cases of cutaneous lupus erythematosus and bullous eruptions such as erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, have been reported with docetaxel.
Danish: Med docetaxel er der rapporter om meget sjældne tilfælde af bulløst udslæt, såsom erythema multiforme, Stevens-Johnson syndrom og toksisk epidermal nekrolyse.
English: DOCETAXEL KABI as single agent
Danish: DOCETAXEL KABI som enkeltstof
English: G-CSF was administered as secondary prophylaxis to patients who experienced complicated neutropenia (febrile neutropenia, prolonged neutropenia, or infection).
Danish: G-CSF blev administreret som sekundær profylakse til patienter, som fik kompliceret neutropeni (febril neutropeni, forlænget neutropen eller infektion).
English: • Then, inject via a single injection (one shot) into a 250 ml infusion bag or bottle containing either 5% glucose solution or sodium chloride 9 mg/ml (0.9%) solution for infusion.
Danish: o Derefter, injicér med en enkelt injektion (one shot) i en 250 ml infusionspose- eller flaske indeholdende enten 5% glucoseopløsning eller natriumchlorid 9 mg/ml (0,9%) infusionsvæske.
English: Infusion site reaction
Danish: Reaktioner på infusionsstedet
English: A survival update analysis conducted with a median follow-up time of 41.6 months no longer showed a statistically significant difference although always in favour of the TCF regimen and showed that the benefit of TCF over CF is clearly observed between 18 and 30 months of follow up.
Danish: En opfølgende analyse af overlevelse efter en median-tid på 41,6 måneder viste ikke længere signifikant forskel, selv om TCF-regimet altid gav bedre resultater.
English: PR = progesterone receptor a ER/PR-negative or Grade 3 or tumour size > 5 cm
Danish: ER/PR-negativ eller grad 3 eller tumorstørrelse >5 cm
English: One large randomised phase III study, involving 429 previously untreated patients with metastatic disease, has been performed with doxorubicin (50 mg/m²) in combination with docetaxel (75 mg/m²) (AT arm) versus doxorubicin (60 mg/m²) in combination with cyclophosphamide (600 mg/m²) (AC arm).
Danish: Et stort randomiseret fase III-studie, med 429 tidligere ubehandlede patienter med metastatisk sygdom, er blevet udført med doxorubicin (50 mg/m2) i kombination med docetaxel (75 mg/2) (AT arm) versus doxorubicin (60 mg/m2) i kombination med cyclophosphamid (600 mg/m2) (AC arm).
English: Median overall survival was also significantly longer in favour of the TPF arm compared to the PF arm (median OS: 18.6 vs. 14.5 months respectively) with a 28% risk reduction of mortality, p = 0.0128.
Danish: Median overlevelse i alt var også signifikant længere til fordel for TPF-armen sammenlignet med PFarmen (median OS: 18,6 vs. 14,5 måneder respektivt) med en 28 % reduktion af risikoen for død, p = 0,0128.
English: The use of docetaxel should be confined to units specialised in the administration of cytotoxic chemotherapy and it should only be administered under the supervision of a physician qualified in the use of anticancer chemotherapy (see section 6.6).
Danish: Anvendelse af docetaxel bør begrænses til afdelinger, der er specialiserede i administration af cytostatika og docetaxel bør kun gives under supervision af en speciallæge i onkologi (se pkt.
English: The median TTP was 37.3 weeks (95% CI: 33.4 - 42.1) in AT arm and 31.9 weeks (95% CI: 27.436.0) in AC arm.
Danish: TTP-medianen var 37,3 uger (95 %CI: 33,4 - 42,1) i AT-armen og 31,9 uger (95 %CI: 27,4 - 36,0) i AC-armen.
English: Cardiac failure; Arrhythmia (no severe)
Danish: Hjertesvigt; Arytmi (ikke alvorlig)
English: Cases of cystoid macular oedema (CMO) have been reported in patients treated with docetaxel.
Danish: Tilfælde af cystoidt makulaødem (CMO) er blevet rapporteret hos patienter behandlet med docetaxel.
English: Febrile neutropenia (G3/4: NA)
Danish: Febril neutropeni (G3/4: NA)
English: Mix the infusion bag or bottle manually using a rocking motion.
Danish: Bland infusionsposen- eller flasken manuelt med vippende bevægelser.
English: In vivo, docetaxel is schedule independent and has a broad spectrum of experimental anti-tumour activity against advanced murine and human grafted tumours.
Danish: In vivo er docetaxels aktivitet uafhængig af behandlingsregimet og har eksperimentielt vist et bredt spektrum af antineoplastisk aktivitet over for murine og transplanterede humane tumorer.
English: • 174 and 251 head and neck cancer patients who received docetaxel in combination with cisplatin and 5-fluorouracil (clinically important treatment related adverse events are presented).
Danish: • 174 og 251 hoved- og hals-kræft-patienter, som blev behandlet med docetaxel i kombination med cisplatin og 5-fluoruracil (klinisk vigtige behandlingsrelaterede bivirkninger er nævnt).
English: • 300 gastric adenocarcinoma patients (221 patients in the phase III part of the study and 79 patients in the phase II part) who received docetaxel in combination with cisplatin and 5-fluorouracil (clinically important treatment related adverse events are presented).
Danish: • 300 gastrisk adenokarcinoma-patienter (221 patienter i fase III-delen af undersøgelsen og 79 patienter i fase II-delen af undersøgelsen), som blev behandlet med docetaxel i kombination med cisplatin og 5-fluoruracil (klinisk vigtige behandlingsrelaterede bivirkninger er nævnt).
English: Rare cases of radiation pneumonitis have been reported in patients receiving concomitant radiotherapy.
Danish: Der er rapporter om sjældne tilfælde af strålepneumonitis hos patienter, som samtidig fik strålebehandling.
English: Headache (G3/4: < 1%); Neuropathy peripheral
Danish: Hovedpine (G3/4: < 1 %); Perifer neuropati
English: Ventricular arrhythmia including ventricular tachycardia (frequency not known), sometimes fatal, has been reported in patients treated with docetaxel in combination regimens including doxorubicin, 5fluorouracil and/ or cyclophosphamide.
Danish: Ventrikulær arytmi inklusive ventrikulær takykardi (hyppighed ikke kendt), undertiden dødelig, er rapporteret hos patienter behandlet med docetaxel i kombinationsregimer, herunder doxorubicin, 5fluorouracil og / eller cyclofosfamid.
English: Patients who experience febrile neutropenia and/or neutropenic infection should have their docetaxel dose reduced to 60 mg/m² in all subsequent cycles (see sections 4.4 and 4.8).
Danish: Patienter, som får febril neutropeni og/eller neutropenisk infektion bør have deres docetaxel-dosis reduceret til 60 mg/m2 i alle efterfølgende cykler (se pkt.
English: The final analysis was performed when all patients had reached their 10-year follow-up visit (unless they had a DFS event or were lost to follow up before).
Danish: Den endelige analyse blev udført, da alle patienter havde nået deres 10 års opfølgningsbesøg (medmindre de havde DFS eller udgik tidligere fra opfølgning).
English: The required volume of DOCETAXEL KABI concentrate for solution for infusion must be injected via a single injection (one shot) into a 250 ml infusion bag or bottle containing either 5% glucose solution or sodium chloride 9 mg/ml (0.9%) solution for infusion.
Danish: Det påkrævede volumen af DOCETAXEL KABI koncentrat til infusionsvæske, opløsning kan injiceres via en enkelt injektion (one shot) i en 250 ml infusionspose- eller flaske indeholdende enten 5% glucoseopløsning eller natriumchlorid 9 mg/ml (0,9%) infusionsvæske.
English: 95% CI p-value† *
Danish: 95 %CI p-værdi†*
English: Recommended dose modifications for toxicities in patients treated with docetaxel in combination with cisplatin and 5-fluorouracil (5-FU):
Danish: De anbefalede dosis-modifikationer for gastrointestinal toksicitet hos patienter behandlet med docetaxel i kombination med cisplatin og 5-fluoruracil (5-FU):
English: There was an increased incidence of SAEs (40% vs. 31%) and Grade 4 AEs (34% vs. 23%) in the trastuzumab combination arm compared to docetaxel monotherapy.
Danish: Der var en forøget forekomst af meget alvorlige bivirkninger (40 % mod 31 %) og grad 4 alvorlige bivirkninger (34 % mod 23 %) i kombination med trastuzumab sammenlignet med docetaxel monoterapi.
English: For capecitabine dose calculation according to body surface area, see capecitabine summary of product characteristics.
Danish: For beregning af capecitabin-dosis i overensstemmelse med legemsoverflade, se capecitabin-produktresuméet.
English: INFORMATION IN BRAILLE Justification for not including Braille accepted.
Danish: INFORMATION I BRAILLESKRIFT Fritaget fra krav om brailleskrift
English: Anorexia (G3/4: 1%); Decreased appetite
Danish: Anoreksi (G3/4: 1 %); Nedsat appetit
English: • Aseptically withdraw the required amount of concentrate for solution for infusion with a calibrated syringe.
Danish: o Udtrak aseptisk den påkrævede mængde koncentrat til infusionsvæske, opløsning med en kalibreret sprøjte.
English: Each vial is for single use and should be used immediately after opening.
Danish: Hvert hætteglas er til engangsbrug og skal anvendes straks efter åbning.
English: There are limited data available in patients > 70 years of age on docetaxel use in combination with doxorubicin and cyclophosphamide.
Danish: Der er begrænsede tilgængelige data vedrørende anvendelse af docetaxel i kombination med doxorubicin og cyclophosphamid til patienter over 70 år.
English: Cystoid macular oedema (CMO) has been reported in patients treated with docetaxel.
Danish: Cystoidt makulaødem (CMO) er blevet rapporteret hos patienter behandlet med docetaxel.
English: • operable node-positive breast cancer
Danish: • operabel, lymfeknude-positiv brystkræft
English: When used in combination, docetaxel does not influence the clearance of doxorubicin and the plasma levels of doxorubicinol (a doxorubicin metabolite).
Danish: Docetaxel influerer ikke på clearence af doxorubicin eller plasmaniveauet af doxorubicinol (en doxorubicinmetabolit), når det anvendes i kombination.
English: G3/4 ALT increased
Danish: G3/4 ALAT forhøjet
English: The development of severe peripheral neurotoxicity requires a reduction of dose (see section 4.2).
Danish: Udvikling af svær perifer neurotoksicitet kræver reduktion af dosis (se pkt.
English: The efficacy and safety evaluation solely addressed survival endpoints and the success of organ preservation was not formally addressed.
Danish: Evaluering af effekt og sikkerhed blev foretaget udelukkende ud fra kriterier om overlevelse.
English: • Induction chemotherapy followed by radiotherapy (TAX 323)
Danish: • Induktionskemoterapi efterfulgt af strålebehandling (TAX 323)
English: For prostate cancer, the premedication is oral dexamethasone 8 mg, 12 hours, 3 hours and 1 hour before the docetaxel infusion (see section 4.2).
Danish: Til prostatakræft er præmedicineringen oral dexamethason 8 mg, 12 timer, 3 timer og 1 time før docetaxel-infusionen (se pkt.
English: If DOCETAXEL KABI concentrate or infusion solution should come into contact with mucous membranes, wash immediately and thoroughly with water.
Danish: Hvis DOCETAXEL KABI koncentrat eller infusionsvæske skulle komme i kontakt med slimhinderne, så vask omgående og grundigt med vand.
English: • For patients developing the first appearance of Grade 2 toxicity, which persists at the time of the next docetaxel/capecitabine treatment, delay treatment until resolved to Grade 0-1, and resume at 100% of the original dose.
Danish: • Hos patienter, der første gang udvikler grad 2-toksicitet, der vedvarer til tidspunktet for den næste docetaxel/capecitabin-behandling skal behandlingen udsættes, til der er grad 0-1toksicitet.
English: In chemotherapy naïve patients treated for non-small cell lung cancer, the recommended dose regimen is docetaxel 75 mg/m2 immediately followed by cisplatin 75 mg/m2 over 30-60 minutes.
Danish: For patienter, der ikke tidligere er behandlet med kemoterapi, der behandles for ikke-småcellet lungekræft, er den anbefalede dosis af docetaxel 75 mg/m2, straks efterfulgt af cisplatin 75 mg/m2 givet over 30-60 minutter.
English: DOCETAXEL KABI in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer.
Danish: DOCETAXEL KABI i kombination med prednison eller prednisolon er indiceret til behandling af patienter med hormonrefraktær metastatisk prostatakræft.
English: The ORR was 59.3% (95% CI: 52.8 - 65.9) in AT arm versus 46.5% (95% CI: 39.8 - 53.2) in AC arm.
Danish: Total responshyppighed var 59,3 % (95 %CI : 52,8 - 65,9) I AT armen i forhold til 46,5 % (95 %CI : 39,8 - 53,2) i AC armen.
English: Frequent monitoring of complete blood counts should be conducted on all patients receiving docetaxel.
Danish: Blodbilledet skal følges løbende hos alle patienter, som behandles med docetaxel.
English: In case of Grade 4 thrombocytopenia the docetaxel dose should be reduced from 75 to 60 mg/m2.
Danish: I tilfælde af grad 4-trombocytopeni bør dosis af docetaxel reduceres fra 75 mg/m2 til 60 mg/m2.
English: The primary efficacy endpoint in this study, overall survival (OS) was significantly longer (log-rank test, p = 0.0058) with the docetaxel-containing regimen compared to PF (median OS: 70.6 versus 30.1 months respectively), with a 30% risk reduction in mortality compared to PF (hazard ratio (HR) = 0.70, 95% confidence interval (CI) = 0.54-0.90) with an overall median follow up time of 41.9 months.
Danish: Det primære endepunkt for effektivitet i dette studie, overlevelse i alt (OS), var signifikant længere (log-rank test, p=0,0058) i det regime, der indeholdt docetaxel sammenlignet med PF (median OS: 70,6 mod 30,1 måneder, respektivt), med en 30 % nedsat risiko i mortalitet sammenlignet med PF (hazard ratio (HR) = 0,70; 95 % konfidensinterval (CI) = 0,54-0,90) med en samlet median opfølgningstid på 41,9 måneder.
English: Amenorrhea was observed to be ongoing at the end of the follow-up period (median follow-up time of 8 years) in 121 of 744 TAC patients (16.3%) and 86 FAC patients (11.7%).
Danish: Det blev observeret, at amenorré fortsatte ved afslutningen af opfølgningsperioden (median opfølgningstid på 8 år) hos 121 af 744 TAC patienter (16,3 %) og hos 86 FAC patienter (11,7 %).
English: For trastuzumab dose and administration, see trastuzumab summary of product characteristics.
Danish: Vedrørende trastuzumab-dosis og -administration, se produktresumé for trastuzumab.
English: Progressive Disease as Best Overall Response (%) *Unstratified logrank test
Danish: Progressiv sygdom som bedste overlevelse respons (%)
English: Infusion site reactions were generally mild and consisted of hyper pigmentation, inflammation, redness or dryness of the skin, phlebitis or extravasation and swelling of the vein.
Danish: Reaktionerne ved infusionsstedet var almindeligvis milde og bestod af hyperpigmentering, inflammation, rødmen eller tørhed, flebitits eller blodudtrækninger og hævelse af venen.
English: • weight gain or loss.
Danish: • Vægtforøgelse eller vægttab
English: Marketing Authorisation Holder Fresenius Kabi Deutschland GmbH Else-Kröner-Straße 1, 61352 Bad Homburg v.d.Höhe Germany
Danish: Indehaver af markedsføringstilladelsen Fresenius Kabi Deutschland GmbH Else-Kröner-Straße 1, 61352 Bad Homburg v.d.Höhe Tyskland
English: Renal insufficiency and renal failure have been reported.
Danish: Nyreinsufficiens og nyresvigt er rapporteret.
English: A total of 449 patients were randomised to receive either docetaxel monotherapy 100 mg/m² as a 1 hour infusion or paclitaxel 175 mg/m² as a 3 hour infusion.
Danish: 449 patienter blev randomiseret til enten at modtage docetaxel monoterapi 100 mg/m2 givet som 1 times infusion eller paclitaxel 175 mg/m2 givet som en infusion over 3 timer.
English: The updated analysis was performed when all patients had reached their 10-year (median follow up time of 10 years and 5 months) follow-up visit (unless they had a DFS event or were lost to follow-up previously).
Danish: Den opdaterede analyse blev udført, da alle patienter havde nået deres 10-års (median opfølgnings-tid var 10 år og 5 måneder) opfølgnings-besøg (medmindre de havde DFS eller tidligere var udgået fra opfølgning).
English: In patients treated with docetaxel in combination with cisplatin and 5-fluorouracil (TCF), febrile neutropenia and neutropenic infection occurred at lower rates when patients received prophylactic G-CSF.
Danish: Hos de patienter, der blev behandlet med docetaxel i kombination med cisplatin og 5-fluoruracil (TCF), opstod der febril neutropeni og neutropenisk infektion i mindre grad, når patienterne fik profylaktisk G-CSF.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Danish: Overfølsomhedsreaktioner forårsaget af det aktive stof eller et af hjælpestofferne anført i pkt.
English: Constipation (severe: 0.2%); Abdominal pain (severe: 1%);
Danish: Konstipation (alvorlig: 0,2 %); Mavesmerter (alvorlig: 1 %);
English: Docetaxel should be administered when the neutrophil count is ≥ 1,500 cells/mm3.
Danish: Docetaxel kan gives, når neutrocyttallet er ≥ 1.500 celler/mm3.
English: Patients on the TAC arm received antibiotic prophylaxis with ciprofloxacin 500 mg orally twice daily for 10 days starting on day 5 of each cycle, or equivalent.
Danish: Patienter på TAC-armen fik antibiotisk profylakse med ciprofloxacin 500 mg oralt 2 gange daglig i 10 dage, startende på dag 5 af hver periode, eller lignende.
English: • chest tightness; difficulty in breathing
Danish: • trykken for brystet, besvær med at trække vejret
English: • oesophagitis
Danish: Oesophagitis (alvorlig:
English: Fresenius Kabi Deutschland GmbH Else-Kröner-Straße 1, 61352 Bad Homburg v.d.Höhe Germany
Danish: Fresenius Kabi Deutschland GmbH Else-Kröner-Straße 1, 61352 Bad Homburg v.d.Höhe Tyskland
English: Tell your doctor, hospital pharmacist or nurse if you have heart problems.
Danish: Kontakt lægen, hospitalsfarmaceuten eller sundhedspersonalet, hvis du har hjerteproblemer.
English: Lacrimation increased; Conjunctivitis
Danish: Forhøjet lakrimation; konjunktivitis
English: In combination with capecitabine, the recommended dose of docetaxel is 75 mg/m2 every three weeks, combined with capecitabine at 1250 mg/m2 twice daily (within 30 minutes after a meal) for 2 weeks followed by 1-week rest period.
Danish: I kombination med capecitabin er den anbefalede DOCETAXEL KABI-dosis 75 mg/m2 hver 3. uge kombineret med capecitabin 1250 mg/m2 to gange daglig (indenfor 30 minutter efter et måltid) i 2 uger efterfulgt af en uges pause.
English: Median duration of response to chemotherapy ± radiotherapy (months) (95% CI)
Danish: Median varighed af respons til kemoterapi ± strålebehandling (måneder) (95 %CI)
English: Some cases of anaphylactic shock, sometimes fatal, have been reported.
Danish: Der er rapporter om anafylaktisk shock, i nogle tilfælde letale.
English: A total of 445 patients with KPS > 70 were treated with either docetaxel (T) (75 mg/m2 on day 1) in combination with cisplatin (C) (75 mg/m2 on day 1) and 5-fluorouracil (F) (750 mg/m2 per day for 5 days) or cisplatin (100 mg/m2 on day 1) and 5-fluorouracil (1000 mg/m2 per day for 5 days).
Danish: 445 patienter med KPS > 70 blev behandlet med enten docetaxel (T) (75 mg/m2 på dag 1) i kombination med cisplatin (C) (75 mg/m2 på dag 1) og 5-fluoruracil (F) (750 mg/m2 pr. dag i 5 dage) eller cisplatin (100 mg/m2 på dag 1) og 5-fluoruracil (1000 mg/m2 pr. dag i 5 dage).
English: • low blood pressure.
Danish: • lavt blodtryk Mere alvorlige reaktioner kan forekomme.
English: In GEICAM 9805 study, 3 patients (0.6 %) in TAC arm and 3 patients (0.6 %) in FAC arm developed congestive heart failure during the follow-up period.
Danish: I studiet GEICAM9805 udviklede 3 patienter (0,6%) i TAC-armen og 3 patienter (0,6%) i FAC-armen kongestivt hjertesvigt i opfølgningsperioden.
English: The safety and efficacy of docetaxel in combination with prednisone or prednisolone in patients with hormone refractory metastatic prostate cancer were evaluated in a randomised multi-centre phase III study.
Danish: Sikkerheden og effekten af docetaxel i kombination med prednison eller prednisolon hos patienter med hormonrefraktær prostatakræft blev undersøgt i et randomiseret multicenter fase III-studium.
English: Neutropenia (G4: 54.2%);
Danish: Neutropeni (G4: 54,2 %);
English: Neutropenic infection; Infection (G3/4: 11.7%)
Danish: Neutropenisk infektion; Infektion (G3/4: 11,7 %)
English: In anthracycline-failure patients, docetaxel was compared to the combination of mitomycin C and vinblastine (12 mg/m² every 6 weeks and 6 mg/m² every 3 weeks).
Danish: Hos de patienter, der tidligere havde fået behandling med anthracyclin uden effekt, blev docetaxel sammenlignet med kombinationsbehandling med mitomycin C og vinblastine (12 mg/m2 hver 6. uge og 6 mg/m2 hver 3. uge).
English: • Docetaxel 75 mg/m2 every 3 weeks for 10 cycles.
Danish: • Docetaxel 75 mg/m2 hver 3. uge i 10 behandlingsrunder.
English: In patients treated with docetaxel in combination with doxorubicin and cyclophosphamide (TAC), febrile neutropenia and/or neutropenic infection occurred at lower rates when patients received primary G-CSF prophylaxis.
Danish: Hos patienter, der blev behandlet med docetaxel i kombination med doxorubicin og cyclophosphamid (TAC), opstod febril neutropeni og/eller neutropenisk infektion sjældnere, når patienterne fik primær G-CSF-profylakse.