FrancophonIA/ELRC3.0 huggingface dataset:
English: Among HIV regimens that can be used (not limited to those below) the following should be taken into account:
Slovenian: Pri načinih zdravljenja HIV, ki so na voljo (niso pa omejeni na spodnje) je treba upoštevati naslednje:
English: Pregnancy and contraception requirements
Slovenian: Zahteve glede nosečnosti in kontracepcije
English: The total dose is 6 tablets per day.
Slovenian: Celokupni odmerek je 6 tablet na dan.
English: These may be symptoms of anaemia.
Slovenian: To so lahko simptomi anemije.
English: Always take the tablets with food.
Slovenian: Tablete vedno jemljite s hrano.
English: Otherwise, the total treatment duration was 48 weeks.
Slovenian: Drugače je zdravljenje trajalo 48 tednov.
English: It is therefore absolutely essential that you take all precautions not to get pregnant during this therapy.
Slovenian: Zato je nujno, da uvedete vse previdnostne ukrepe, da med tem zdravljenjem ne zanosite.
English: - 3 tablets of INCIVO twice daily (morning and evening) with food.
Slovenian: - 3 tablete zdravila INCIVO dvakrat na dan (zjutraj in zvečer) s hrano.
English: amlodipine, diltiazem, felodipine, nicardipine,
Slovenian: amlodipin, diltiazem, felodipin, nikardipin,
English: Data in the paediatric population are currently not available.
Slovenian: Podatki za pediatrično populacijo niso na voljo.
English: Hispanic Latino
Slovenian: Španskega oziroma latinskoameriškega rodu
English: The incidence was calculated by the number of patients for each parameter.
Slovenian: Pogostnost je bila izračunana glede na število bolnikov za vsak parameter posebej.
English: More than 90% of rashes were of mild or moderate severity.
Slovenian: V več kot 90% primerov je bil izpuščaj blag ali zmeren.
English: The rash may take several weeks to resolve.
Slovenian: To lahko traja tudi več tednov.
English: At steady-state, the effective half-life is about 9-11 hours.
Slovenian: V stanju dinamičnega ravnovesja je učinkoviti razpolovni čas približno 9-11 ur.
English: INCIVO is not for use in children or adolescents, because it has not been sufficiently studied in
Slovenian: Zdravilo INCIVO ni namenjeno uporabi pri otrocih ali mladostnikih, ker ni bilo zadostno preučeno pri
English: - to check for changes in some values of your blood cells or chemistry.
Slovenian: - preveril spremembe nekaterih vrednosti vaših krvnih celic in biokemičnih lastnosti krvi.
English: Simvastatin is contraindicated due to the predicted marked increase in exposure caused by multiple mechanisms.
Slovenian: Sočasna uporaba s simvastatinom je kontraindicirana zaradi predvidenega izrazitega povečanja izpostavljenosti, ki je posledica več mehanizmov.
English: The marketing authorisation holder shall submit periodic safety update reports for this product in accordance with the requirements set out in the list of Union reference dates (EURD list) ) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web
Slovenian: • Redno posodobljena poročila o varnosti zdravila (PSUR) Imetnik dovoljenja za promet z zdravilom mora redno posodobljena poročila o varnosti zdravila za to zdravilo predložiti v skladu z zahtevami, določenimi v seznamu referenčnih datumov Unije (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES in objavljenem na evropskem spletnem
English: Effect on concentration of INCIVO or concomitant medicinal product and possible mechanism
Slovenian: Vpliv na koncentracijo zdravila INCIVO oziroma drugega sočasno uporabljenega zdravila in verjetni mehanizem delovanja
English: Do not take INCIVO if you are allergic to telaprevir or any of the other ingredients of this medicine
Slovenian: Ne jemljite zdravila INCIVO, če ste alergični na telaprevir ali katerokoli sestavino tega zdravila
English: Make sure that you check the following points and tell your doctor treating your hepatitis C virus (HCV) if any of these apply to you.
Slovenian: Preveriti morate naslednje navedbe in povedati zdravniku, ki zdravi okužbo z virusom hepatitisa C (HCV), če katera od njih velja za vas.
English: The Physician Leaflet should contain the following key elements:
Slovenian: Navodilo za uporabo za zdravnike mora vsebovati naslednje ključne elemente:
English: What INCIVO is and what it is used for
Slovenian: Kaj je zdravilo INCIVO in za kaj ga uporabljamo
English: Treatment of overdose with INCIVO consists of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient.
Slovenian: Zdravljenje prevelikega odmerjanja zdravila INCIVO je sestavljeno iz splošnih podpornih ukrepov, vključno s spremljanjem vitalnih znakov in opazovanjem bolnikovega kliničnega stanja.
English: Refer to section 4.4, Laboratory tests.
Slovenian: Glejte poglavje 4.4 Laboratorijske preiskave.
English: What INCIVO is and what it is used for What you need to know before you take INCIVO
Slovenian: Kaj je zdravilo INCIVO in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo INCIVO
English: Increased plasma concentrations of quetiapine may lead to coma.
Slovenian: Povečane koncentracije kvetiapina lahko vodijo v komo.
English: Maximum plasma concentrations after a single dose of telaprevir are generally achieved after 4 - 5 hours.
Slovenian: Največje plazemske koncentracije po zaužitju enkratnega odmerka telaprevirja so običajno dosežene po 4 do 5 urah.
English: In rats and dogs, telaprevir was associated with a reversible reduction of red blood cell parameters accompanied by a regenerative response.
Slovenian: Pri podganah in psih je bila uporaba telaprevirja povezana z reverzibilnim zmanjšanjem parametrov rdečih krvničk, ki ga je spremljal regenerativni odziv.
English: The NS3-4A protease inhibitor reduces the amount of hepatitis C virus in your body.
Slovenian: Zaviralci NS3-4A proteaze zmanjšajo količino virusa hepatitisa C v telesu.
English: After ending treatment, approximately one week may be needed for the inhibition to completely disappear.
Slovenian: Po zaključku zdravljenja je potreben približno en teden, da zaviranje popolnoma izzveni.
English: The clinical implications of this finding are currently unknown.
Slovenian: Klinični pomen teh izsledkov trenutno ni znan.
English: Extent and features of Cutaneous Reactions
Slovenian: Obseg in značilnosti kožne reakcije
English: Co-administration should be done in a setting which ensures clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Slovenian: Sočasno uporabo je treba izvajati v okolju, ki zagotavlja klinično spremljanje in ustrezno medicinsko zdravljenje v primeru depresije dihanja in/ali podaljšane sedacije.
English: to decrease blood pressure (calcium channel blockers) to treat HIV infections (CCR5 antagonist)
Slovenian: za znižanje krvnega tlaka (zaviralci kalcijevih kanalčkov) za zdravljenje okužbe s HIV (antagonist CCR5)
English: In rats (but not in dogs), telaprevir caused degenerative changes in testes which were reversible and did not affect fertility.
Slovenian: Pri podganah (pri psih pa ne) je telaprevir povzročil degenerativne spremembe v modih, ki so bile reverzibilne in niso vplivale na plodnost.
English: No clinical studies have been performed in paediatric patients.
Slovenian: Pri pediatričnih bolnikih niso opravili nobenih kliničnih študij.
English: The time dependency indicates that inhibition of CYP3A4 may be intensified during the first 2 weeks of treatment.
Slovenian: Spremljanje časovne odvisnosti kaže, da se zaviranje CYP3A v prvih dveh tednih zdravljenja lahko stopnjuje.
English: INCIVO has only been used in a limited number of patients of 65 years or older.
Slovenian: Zdravilo INCIVO je bilo doslej uporabljeno le pri omejenem številu bolnikov, starih 65 let ali več.
English: Please see section ‘Other medicines and INCIVO'.
Slovenian: Glejte poglavje ‘Druga zdravila in zdravilo INCIVO'.
English: However, sufficiently high concentrations were not tested for intestinal inhibition to be excluded.
Slovenian: Vendar niso preskušali dovolj velikih koncentracij, da bi lahko izključili zaaviranje v črevesju.
English: It may appear at any time after start of treatment, although the majority of cases appeared between six and ten weeks after the start of treatment with INCIVO.
Slovenian: Pojavi se lahko kadarkoli po začetku zdravljenja, v večini primerov se je pojavil v obdobju med šestim in desetim tednom zdravljenja z zdravilom INCIVO.
English: Eesti filiaal Lõõtsa 2
Slovenian: Eesti filiaal
English: - to check if you have anaemia (decrease in your red blood cells).
Slovenian: - preveril, ali ste anemični (imate zmanjšano število rdečih krvničk).
English: Telaprevir is extensively metabolised in the liver, involving hydrolysis, oxidation, and reduction.
Slovenian: Telaprevir se obsežno presnovi v jetrih s hidrolizo, oksidacijo in redukcijo.
English: The food is important to get the right levels of medicine in your body.
Slovenian: To je pomembno, da dosežete primerne koncentracije zdravila v vašem telesu.
English: The median recovery of the administered radioactive dose was approximately 82% in the faeces, 9% in exhaled air and 1% in urine.
Slovenian: Mediane vrednosti izmerjenega radioaktivnega odmerka so bile približno 82% v blatu, 9% v izdihanem zraku in 1% v seču.
English: These recommendations are based on either drug interaction studies (indicated with *) or predicted interactions due to the expected magnitude of interaction and potential for serious adverse reactions or loss of efficacy.
Slovenian: Ta priporočila temeljijo na študijah njegovih interakcij z drugimi zdravili (kar je označeno z *) ali na napovedanih interakcijah glede pričakovane stopnje interakcij in nevarnosti za pojav resnih neželenih učinkov ali neučinkovitost zdravljenja.
English: For additional information on mild to moderate rash, see section 4.8.
Slovenian: Za dodatne informacije o blagih do zmernih izpuščajih glejte poglavje 4.8.
English: INCIVO is not recommended for use in children and adolescents younger than 18 years of age because the safety and efficacy has not been established in this population.
Slovenian: Uporaba zdravila INCIVO pri otrocih in mladostnikih, mlajših od 18 let ni priporočena, ker njegova varnost in učinkovitost pri tej populaciji še ni bila ugotovljena.
English: Usually the rash is mild or moderate, but the rash may be, or may become, severe and/or life-threatening.
Slovenian: Običajno je ta izpuščaj blag ali zmeren, lahko pa je ali postane tudi hud in/ali življenju nevaren.
English: For outcomes obtained in HIV co-infected patients, see section 5.1.
Slovenian: Za izide pri bolnikih s sočasno okužbo s HIV glejte poglavje 5.1.
English: ADRs are listed by system organ class (SOC) and frequency: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100) and rare (≥ 1/10,000 to < 1/1,000).
Slovenian: Neželeni učinki so razvrščeni po organskih sistemih in pogostnosti: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100) in redki (≥ 1/10.000 do < 1/1.000).
English: Pharmacotherapeutic group: Direct-acting antiviral, ATC code: J05AE11.
Slovenian: Farmakoterapevtska skupina: Protivirusna zdravila z neposrednim delovanjem, oznaka ATC: J05AE11
English: What you need to know before you take INCIVO
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo INCIVO
English: However, patients treated with peginterferon alfa-2b experienced more frequent viral breakthrough, and were less likely to meet the criteria for shortened total treatment duration (see section 5.1).
Slovenian: Vendar je pri bolnikih, ki so prejemali peginterferon alfa-2b pogosteje prišlo do virološkga preboja in so imeli manjšo verjetnost, da bodo ustrezali kriterijem za skrajšanje celokupnega trajanja zdravljenja (glejte poglavje 5.1).
English: Two months after completion of INCIVO treatment, hormonal contraceptives are again appropriate as one of the two required effective methods of birth control.
Slovenian: Dva meseca po zaključku zdravljenja z zdravilom INCIVO so hormonski kontraceptivi spet primerni kot ena od dveh zahtevanih učinkovitih kontracepcijskih metod.
English: When co-administration is required, high doses of itraconazole (> 200 mg/day) or ketoconazole (> 200 mg/day) are not recommended.
Slovenian: Kadar je potrebna sočasna uporaba teh zdravil, veliki odmerki itrakonazola (> 200 mg/dan) ali ketokonazola (> 200 mg/dan), niso priporočljivi.
English: There are no data from the use of INCIVO in pregnant women.
Slovenian: Ni podatkov o uporabi zdravila INCIVO pri nosečnicah.
English: However, when fed via milk from telaprevir-treated dams, body weight gain of rat pups was lower than normal (likely due to taste aversion).
Slovenian: Če pa so jih hranili z mlekom samic, ki so prejemale telaprevir, je bilo pridobivanje telesne mase mladičev počasnejše kot je normalno (verjetno zaradi neprijetnega okusa mleka).
English: If you have both hepatitis C virus infection and human immunodeficiency virus infection, and are taking efavirenz, the recommended dose regimen is 3 tablets of INCIVO every 8 hours with food.
Slovenian: Če imate okužbo z virusom hepatitisa C in virusom imunske pomankljivosti pri človeku in jemljete efavirenz, je priporočljivi odmerek zdravila INCIVO 3 tablete na vsakih 8 ur, s hrano.
English: Replicon variants generated from patient-derived sequences showed similar results.
Slovenian: Tudi variante replikonov, dobljene iz sekvenc, odvzetih od bolnikov, so dale podobne rezultate.
English: The Marketing Authorisation Holder shall ensure that all physicians who are expected to prescribe or use INCIVO are provided with a healthcare professional educational pack containing the following:
Slovenian: Imetnik dovoljenja za promet z zdravilom bo zagotovil, da bodo zdravniki, ki bodo predpisovali ali uporabljali zdravilo INCIVO prejeli izobraževalno gradivo, ki bo vsebovalo:
English: What INCIVO looks like and contents of the pack Film-coated tablet.
Slovenian: Izgled zdravila INCIVO in vsebina pakiranja Filmsko obložena tableta.
English: These may be symptoms of anaemia (decrease in your red blood cells);
Slovenian: To so lahko znaki anemije (zmanjšanja števila rdečih krvnih celic).
English: Patients should be instructed to swallow the tablets whole (e.g. patients should not chew, break or
Slovenian: Bolnike je treba poučiti, naj tablete pogoltnejo cele (ne smejo jih žvečiti, zlomiti ali raztopiti).
English: Do not use INCIVO in combination with any of the following medicines as they may increase the risk of severe side effects, and/or affect the way INCIVO or the other medicine works:
Slovenian: Ne jemljite zdravila INCIVO skupaj z naslednjimi zdravili, ker lahko povečajo tveganje za pojav hudih neželenih učinkov in/ali vplivajo na delovanje zdravila INCIVO ali drugih zdravil:
English: The effect of subject gender on telaprevir pharmacokinetics was evaluated using population pharmacokinetics of data from Phase 2 and 3 studies of INCIVO.
Slovenian: Vpliv spola preiskovanca na farmakokinetiko telaprevirja so ovrednotili s pomočjo podatkov populacijske farmakokinetike iz študij zdravila INCIVO faze II in III.
English: Other enzymes are also involved in the metabolism such as aldo-ketoreductases and other proteolytic enzymes.
Slovenian: V presnovo so lahko vključeni tudi drugi encimi, kot so aldo-ketoreduktaze in drugi proteolitični encimi.
English: Patients Co-infected with HIV-1
Slovenian: Bolniki, sočasno okuženi z virusom HIV-1
English: INCIVO tablets should be stored in the original bottle.
Slovenian: Tablete INCIVO shranjujte v originalni plastenki.
English: Transfusion rates over the whole study period were 4.6% and 1.6%, respectively.
Slovenian: Stopnja transfuzije je bila 4,6% in 1,6% za vsako skupino v celotnem času trajanja študij.
English: Tell your doctor if you have an hepatitis B infection so that your doctor can decide if INCIVO
Slovenian: Povejte svojemu zdravniku, če imate okužbo z virusom hepatitisa B, da se bo lahko odločil ali je zdravilo INCIVO primerno za vas.
English: The SVR rate for Black patients was 62% (45/73).
Slovenian: Stopnja trajnega virološkega odziva pri bolnikih iz skupine črncev je bila 62% (45/73).
English: In vitro studies with recombinant UGT1A3 suggested that telaprevir may inhibit this enzyme.
Slovenian: In vitro študije z rekombinantnim UGT1A3 kažejo na možnost, da telaprevir zavira ta encim.
English: The safety and efficacy of INCIVO in children aged < 18 years have not yet been established.
Slovenian: Varnost in učinkovitost zdravila INCIVO pri otrocih, starih < 18 let, še nista ugotovljeni.
English: In clinical trials, the majority of patients were administered antihistamines and topical corticosteroids.
Slovenian: V kliničnih preskušanjih so večini bolnikov predpisali antihistaminike in lokalne kortikosteroide.
English: An effect of telaprevir on UDP-glucuronyltransferases cannot be ruled out and may affect the plasma concentrations of abacavir or zidovudine.
Slovenian: Učinka telaprevirja na UDP-glukuroniltransferaze ne moremo izključiti in lahko vpliva na plazemske koncentracije abakavirja ali zidovudina.
English: However, clinical monitoring is recommended as the dose of methadone during maintenance therapy may need to be adjusted in some patients.
Slovenian: Kljub temu pa je priporočljivo klinično spremljanje, ker bo lahko pri nekaterih bolnikih potrebna prilagoditev odmerka metadona v času vzdrževalnega zdravljenja z njim.
English: The total treatment duration was determined based on the patients' individual on-treatment viral response.
Slovenian: Celokupen čas zdravljenja je bil določen glede na virološki odziv posameznega bolnika.
English: Your doctor will decide on the appropriate dose regimen for you.
Slovenian: Zdravnik vam bo predpisal režim jemanja zdravila, ki je primeren za vas.
English: This difference is likely due to the higher genetic barrier for the V36M and R155K substitutions for genotype 1b than genotype 1a.
Slovenian: Ta razlika je bila verjetno posledica večje genetske ovire substituciji V36M in R155K pri genotipu 1b kot pri genotipu 1a.
English: The lower limit of the 95% CI (-4.9%) was greater than the pre-determined noninferiority margin of -11% and therefore the non inferiority of T12(b.i.d.
Slovenian: Vrednost spodnje meje 95% IZ (-4,9%) je bila višja od vnaprej določene meje primerljivosti, ki je bila -11%, in zato je bila dokazana primerljivost režimov T12(b.i.d.
English: If you are taking INCIVO twice daily (morning and evening) If you notice the missed dose within 6 hours, you must take three tablets immediately.
Slovenian: Če jemljete zdravilo INCIVO dvakrat na dan (zjutraj in zvečer) Če se na pozabljeni odmerek spomnite v roku 6 ur, morate takoj zaužiti tri tablete.
English: Clinical relevance unknown.
Slovenian: Klinični pomen ni znan.
English: Caution should be used and dose reduction for amlodipine should be considered.
Slovenian: Potrebna je previdnost in po potrebi tudi zmanjšanje odmerka amlodipina.
English: Voriconazole should not be administered to patients receiving telaprevir unless an assessment of the benefit/risk ratio justifies its use.
Slovenian: Vorikonazola ne smete predpisovati bolnikom, ki prejemajo telaprevir, razen če njegovo uporabo opravičuje ocena razmerja med tveganjem in koristjo.
English: Fatal cases have been reported in patients with progressive rash and systemic symptoms who continued to receive INCIVO combination treatment after a serious skin reaction was identified.
Slovenian: O smrtnih primerih so poročali pri bolnikih z napredujočim izpuščajem in sistemskimi simptomi, ki so prejemali kombinirano terapijo z zdravilom INCIVO tudi po pojavu hude kožne reakcije.
English: The rash reported during INCIVO combination treatment was assessed as a typically pruritic, eczematous rash, and involved less than 30% of body surface area.
Slovenian: Izpuščaj, o katerem so poročali pri kombiniranem zdravljenju z zdravilom INCIVO, so ocenili kot značilno pruritičen, ekcematozen izpuščaj, ki je zajemal manj kot 30% telesne površine.
English: Plasma HCV RNA values were measured using the COBAS
Slovenian: Plazemske vrednosti HCV RNK so merili s pomočjo testa COBAS
English: Signs and symptoms of dehydration include increased thirst, dry mouth, decreased urine frequency or volume, and dark coloured urine.
Slovenian: Znaki in simptomi dehidracije obsegajo povečano žejo, suha usta, zmanjšano pogostnost uriniranja ali zmanjšano količino urina in temno obarvan urin.
English: Electrolyte disturbances (e.g., hypokalaemia, hypomagnesaemia and hypocalcaemia) should be monitored and corrected, if necessary, prior to initiation and during INCIVO therapy.
Slovenian: Motnje elektrolitov (npr. hipokaliemija, hipomagneziemija in hipokalcemija) je treba spremljati in jih po potrebi odpraviti še pred uvedbo zdravila INCIVO oziroma med zdravljenjem.
English: Detailed information on this medicine is available on the European Medicines Agency (EMA) web
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila
English: Refer to sections 4.4 and 4.6.
Slovenian: Glejte poglavji 4.4 in 4.6.
English: In INCIVO clinical experience, less than 0.1% of patients had Stevens-Johnson Syndrome (SJS).
Slovenian: V okviru kliničnih izkušenj z zdravilom INCIVO se je Stevens-Johnsonov sindrom (SJS) pojavil pri manj kot 0,1% bolnikov.
English: Tell your doctor if you have had other problems with your liver such as liver failure.
Slovenian: Povejte zdravniku, če ste imeli kdaj kakšne druge težave z jetri, kot je jetrna odpoved.
English: P < 0.001, T12/PR compared to Pbo/PR48.
Slovenian: P < 0,001, T12/PR za primerjavo s Pbo/PR48.
English: A decrease in haemoglobin levels occurs during the first 4 weeks of treatment, with lowest values reached at the end of INCIVO dosing.
Slovenian: Do zmanjšanja koncentracije hemoglobina pride v prvih 4 tednih zdravljenja, najnižje vrednosti pa so dosežene ob koncu jemanja zdravila INCIVO.
English: T12/PR All Patients
Slovenian: T12/PR Vsi bolniki
English: Dosing of the animals did not result in any exposure-margin when compared to human exposure.
Slovenian: Odmerki pri živalih niso dosegali meje izpostavljenosti v primerjavi z ljudmi.
English: Drug interactions need to be carefully taken into account, see sections 4.4 and 4.5.
Slovenian: Skrbno je treba upoštevati interakcije z drugimi zdravili, glejte poglavji 4.4 in 4.5.
English: Atazanavir/ritonavir: this combination is associated with a high frequency of hyperbilirubinaemia/icterus.
Slovenian: Atazanavir/ritonavir: to kombinacijo povezujejo z veliko pogostnostjo hiperbilirubinemije/zlatenice.
English: Important information about some of the ingredients of INCIVO This medicinal product contains 2.3 mg sodium per tablet, which should be taken into consideration by patients on a controlled sodium diet.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila INCIVO To zdravilo vsebuje 2,3 mg natrija na tableto, kar je treba upoštevati pri bolnikih na dieti z
English: In case of overdose you may experience nausea, headache, diarrhoea, decreased appetite, abnormal
Slovenian: V primeru prevelikega odmerka se lahko pojavi slabost, glavobol, driska, zmanjšan apetit, nenormalen
English: atazanavir/ritonavir, darunavir/ritonavir, fosamprenavir/ritonavir, lopinavir/ritonavir to treat HIV infections (HIV-protease inhibitors)
Slovenian: atazanavir/ritonavir, darunavir/ritonavir, fosamprenavir/ritonavir, lopinavir/ritonavir za zdravljenje okužbe s HIV (zaviralci proteaze HIV)
English: It is not known whether telaprevir is excreted in human breast milk.
Slovenian: Ni znano, ali se telaprevir pri človeku izloča v materino mleko.
English: Prescribers should ensure that patients are fully informed about the risk of severe rashes, and to consult with their prescriber immediately if they develop a new rash or worsening of an existing rash.
Slovenian: Zdravnik mora zagotoviti, da so bolniki natančno poučeni o tveganju za pojav hudih izpuščajev in o tem, da se morajo ob pojavu izpuščaja ali ob poslabšanju obstoječega izpuščaja takoj posvetovati s svojim zdravnikom.
English: If you notice the missed dose within 4 hours, you must take two tablets immediately.
Slovenian: Če se na pozabljeni odmerek spomnite v roku 4 ur, morate takoj zaužiti dve tableti.