FrancophonIA/ELRC3.0 huggingface dataset:
English: When efavirenz was given with ritonavir 500 mg or 600 mg twice daily, the combination was not well tolerated (for example, dizziness, nausea, paraesthesia and elevated liver enzymes occurred).
Icelandic: Þegar efavírenz var gefið með rítónavíri 500 mg eða 600 mg tvisvar á dag, þoldist samsetningin ekki vel.
English: Dosage adjustments of atorvastatin may be required when co-administered with Atripla (refer to the Summary of Product Characteristics for atorvastatin).
Icelandic: Nauðsynlegt getur verið að aðlaga skammtastærð atorvastatíns þegar gefið með Atripla (sjá Samantekt á eiginleikum lyfs fyrir atorvastatín).
English: Indinavir/Tenofovir disoproxil (800 mg q8h/245 mg q.d.)
Icelandic: Indínavír/tenofovír tvísóproxíl (800 mg á 8 klst. fresti/245 mg einu sinni á dag)
English: There is no clinical experience with Atripla in patients who are experiencing virological failure in a first-line antiretroviral treatment regimen or in combination with other antiretroviral agents.
Icelandic: Atripla hjá sjúklingum þar sem meðferð gegn retróveirum hefur brugðist ein sér eða ásamt öðrum lyfjum gegn retróveirum.
English: EXPIRY DATE
Icelandic: Frábendingar samtímis notkunar
English: The safety and efficacy of Atripla have not been studied for the treatment of chronic HBV infection.
Icelandic: Atripla hafa ekki verið rannsökuð við meðferð á langvinnri sýkingu af völdum lifrarbólgu
English: Efavirenz, emtricitabine and tenofovir have been shown to be excreted in human milk.
Icelandic: Sýnt hefur verið fram á að efavírenz, emtrícítabín og tenófóvír skiljast út í brjóstamjólk.
English: - severe disturbances of electrolyte balance e.g. hypokalemia or hypomagnesemia.
Icelandic: - verulegar truflanir á blóðsaltajafnvægi, t.d. blóðkalíumlækkun eða blóðmagnesíumlækkun.
English: Raltegravir/Tenofovir disoproxil (400 mg b.i.d./-)
Icelandic: Raltegravír/tenófovír tvísóproxíl (400 mg tvisvar sinnum á dag/-)
English: Sofosbuvir/Velpatasvir (400 mg/100 mg q.d.)
Icelandic: Sófosbúvír/velpatasvír (400 mg/100 mg einu sinni á dag)
English: Atripla is a fixed-dose combination of efavirenz, emtricitabine and tenofovir disoproxil fumarate.
Icelandic: Atripla er föst skammtasamsetning efavírenz, emtrícítabíns og tenófóvír tvísóproxíl fúmarats.
English: Buprenorphine/naloxone/Efavirenz
Icelandic: Búprenorfín/naloxon/efavírenz
English: Psychiatric symptoms
Icelandic: LYFJAGERÐARFRÆÐILEGAR UPPLÝSINGAR
English: Dosage adjustments of pravastatin may be required when co-administered with Atripla (refer to the Summary of Product Characteristics for pravastatin).
Icelandic: Nauðsynlegt getur verið að aðlaga skammtastærð pravastatíns þegar gefið með Atripla (sjá Samantekt á eiginleikum lyfs fyrir pravastatín).
English: 300 mg/ritonavir 100 mg q.d.
Icelandic: 800 ml/kg.
English: Tenofovir disoproxil and emtricitabine, two of the active substances in Atripla, show some activity against hepatitis B virus although emtricitabine is not approved for the treatment of hepatitis B infection.
Icelandic: Tenófóvír tvísóproxíl og emtrícítabín, tvö af virku innihaldsefnunum í Atripla hafa sýnt einhverja virkni gegn lifrarbólgu
English: The potential for interactions with efavirenz and other azole antifungals, such as ketoconazole, has not been studied.
Icelandic: Hugsanlegar milliverkanir efavírenz og annarra azól sveppalyfja, svo sem ketókónazóls, hafa ekki verið rannsakaðar.
English: Uncommon rhabdomyolysis2, muscular weakness2
Icelandic: Sjaldgæfar rákvöðvalýsa2, vöðvaslen2
English: Morning Cmin: ↑ 42% (↑ 9 to ↑ 86) Evening Cmin: ↑ 24% (↑ 3 to ↑ 50)
Icelandic: ↑ 42% (↑ 9 til ↑ 86) Kvöld Cmin:
English: • proteins in urine
Icelandic: • prótein í þvagi
English: Patients with moderate or severe renal impairment require dose interval adjustment of emtricitabine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.4 and 5.2).
Icelandic: Hjá sjúklingum með miðlungsmikla eða alvarlega skerta nýrnastarfsemi þarf að aðlaga bil milli skammta emtrícítabíns og tenófóvír tvísóproxíl sem ekki næst með samsettu töflunni (sjá kafla 4.4 og 5.2).
English: Test: single fixed-dose combination tablet taken under fasted conditions.
Icelandic: Ein samsett tafla með föstum skammti tekin á fastandi maga.
English: Expected:
Icelandic: Gert ráð fyrir:
English: Dosage adjustments of simvastatin may be required when co-administered with Atripla (refer to the Summary of Product Characteristics for simvastatin).
Icelandic: Nauðsynlegt getur verið að aðlaga skammtastærð simvastatíns þegar gefið með Atripla (sjá Samantekt á eiginleikum lyfs fyrir simvastatín).
English: Rash: In clinical trials of efavirenz, rashes were usually mild-to-moderate maculopapular skin eruptions that occurred within the first two weeks of initiating therapy with efavirenz.
Icelandic: á efavírenz voru útbrot venjulega væg eða miðlungsmikil dröfnuörðu húðútþot sem komu fram á fyrstu tveimur vikunum eftir að meðferð með efavírenz hefst.
English: Mechanism of action and pharmacodynamic effects Efavirenz is an NNRTI of HIV-1.
Icelandic: Efavírenz er HIV-1 bakritahemill, sem ekki er núkleósíð (NNRTI).
English: AUC: ↓ 60% (↓ 52 to ↓ 68) Cmax: ↓ 62% (↓ 55 to ↓ 78)
Icelandic: ↓ 60% (↓ 52 til ↓ 68) Cmax:
English: Limited clinical experience suggests that emtricitabine and tenofovir disoproxil have an anti-HBV activity when used in antiretroviral combination therapy to control HIV infection.
Icelandic: Takmörkuð klínísk reynsla bendir til þess að emtrícítabín og tenófóvír tvísóproxíl verki gegn lifrarbólgu
English: The net effect of co-administration is not clear.
Icelandic: Bein áhrif samtímis lyfjagjafar eru ekki ljós.
English: AUC: ↓ 69% (↓ 62 to ↓ 73) Cmax: ↓ 76% (↓ 63 to ↓ 79)
Icelandic: ↓ 69% (↓ 62 til ↓ 73)
English: AUC: ↔*/** (↓ 10% to ↑ 26%) Cmax: ↔*/** (↓ 5% to ↑ 26%) Cmin: ↑ 12%*/** (↓ 16 to ↑ 49)
Icelandic: ↔*/** (↓ 5% til ↑ 26%) Cmin:
English: * When compared to atazanavir
Icelandic: * Þegar miðað er við atazanavír
English: Atripla is not recommended in this population (see section 4.2).
Icelandic: Atripla fyrir þennan aldurshóp (sjá kafla 4.2).
English: It is anticipated that tenofovir exposure (AUC) will be approximately 30% lower following administration of Atripla on an empty stomach as compared to the individual component tenofovir disoproxil when taken with food (see section 5.1).
Icelandic: 30% eftir að Atripla hefur verið gefið á fastandi maga samanborið við gjöf staka innihaldsefnisins tenófóvír tvísóproxíl með mat (sjá kafla 5.1).
English: Simvastatin acid:
Icelandic: Ónæmiskerfi:
English: • inflammation of the kidney, passing a lot of urine and feeling thirsty
Icelandic: • bólga í nýrum, mikil þvaglát og þorsti
English: Discontinuation of Atripla therapy in patients co-infected with HIV and HBV may be associated with severe acute exacerbations of hepatitis.
Icelandic: Þegar Atripla meðferð er hætt hjá sjúklingum sem samtímis eru sýktir af HIV og lifrarbólgu
English: - if you have a history of liver disease, including chronic active hepatitis.
Icelandic: ef þú hefur haft lifrarsjúkdóm að meðtalinni langvinnri, virkri lifrarbólgu.
English: AUC: ↔ Cmax: ↔
Icelandic: ↔ Cmax: ↔
English: Selective Serotonin Reuptake Inhibitors (SSRIs) Sertraline/Efavirenz (50 mg q.d./600 mg q.d.)
Icelandic: Sértækir serótónín endurupptökuhemlar (SSRI) Sertralín/efavírenz (50 mg einu sinni á dag/600 mg einu sinni á dag)
English: Atripla contains sodium
Icelandic: Atripla inniheldur natríum
English: AUC: ↓ 58% (↓ 39 to ↓ 68) Cmax: ↓ 51% (↓ 32 to ↓ 58)
Icelandic: ↓ 58% (↓ 39 til ↓ 68)
English: AUC: ↓ 34% (↓ 21 to ↓ 41) Cmax: ↓ 20% (↓ 2 to ↓ 26)
Icelandic: ↓ 34% (↓ 21 til ↓ 41) Cmax:
English: AUC: ↓ 54% Cmax: ↓ 45%
Icelandic: ↓ 54% Cmax:
English: Carbamazepine:
Icelandic: Karbamazepín:
English: AUC: ↓ 43% (↓ 7 to ↓ 65) Cmax: ↔
Icelandic: ↓ 43% (↓ 34 til ↓ 50) Cmax:
English: Atorvastatin/Emtricitabine
Icelandic: Atorvastatín/emtricitabín
English: Paroxetine/Efavirenz (20 mg q.d./600 mg q.d.)
Icelandic: Paroxetín/efavírenz (20 mg einu sinni á dag/600 mg einu sinni á dag)
English: Resistance to emtricitabine or tenofovir has been seen in vitro and in some HIV-1 infected patients due to the development of an M184V or M184I substitution in RT with emtricitabine or a K65R substitution in RT with tenofovir.
Icelandic: M184V eða M184I skiptihvarfs í bakrita hvað varðar emtrícítabín og K65R skiptihvarfs í bakrita hvað varðar tenófóvír.
English: Paroxetine/Tenofovir disoproxil
Icelandic: Paroxetín/tenófóvír tvísóproxíl
English: AUC: ↓ 83% (↓ 79 to ↓ 87) Cmax: ↓ 80% (↓ 77 to ↓ 83) Cmin: ↓ 86% (↓ 80 to ↓ 90)
Icelandic: ↓ 80% (↓ 77 til ↓ 83) Cmin:
English: Atripla and rosuvastatin can be co-administered without dose adjustment.
Icelandic: Atripla og rósúvastatín má gefa samhliða án skammtaaðlögunar
English: Atripla may make hormonal contraceptives less likely to work.
Icelandic: Atripla kann að draga úr virkni getnaðarvarnarlyfs með hormónum.
English: Fosamprenavir/ritonavir/Tenofovir disoproxil
Icelandic: Saquínavír/rítónavír/tenófóvír tvísóproxíl
English: AUC: ↔ Cmax: ↓ 23% (↓ 30 to ↑ 16)
Icelandic: ↓ 23% (↓ 30 til ↑ 16)
English: Musculoskeletal and connective tissue disorders: Very common elevated creatine kinase
Icelandic: Mjög algengar hækkaður kreatínkínasi
English: • angry behaviour, suicidal thoughts, strange thoughts, paranoia, unable to think clearly, mood being affected, seeing or hearing things that are not really there (hallucinations), suicide attempts, personality change (psychosis), catatonia (a condition in which the patient is rendered motionless and speechless for a period).
Icelandic: • reiði, sjálfsvígshugsanir, undarlegar hugsanir, ofsóknarkennd, óskýrar hugsanir, skapsveiflur,
English: Sertraline/Tenofovir disoproxil
Icelandic: Sertralín/tenófóvír tvísóproxíl
English: AUC: ↓ 35% (↓ 13 to ↓ 40) Cmax: ↓ 13% (↓ 0 to ↓ 23)
Icelandic: ↓ 35% (↓ 13 til ↓ 40) Cmax:
English: Carcinogenicity studies in male mice, male and female rats were negative.
Icelandic: Engin krabbmeinsvaldandi áhrif komu fram við rannsóknir hjá karlmúsum og karl- og kvenrottum.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
Icelandic: B eða C er jafnframt vísað til viðkomandi Samantektar á eiginleikum lyfs fyrir þau lyf.
English: Atripla and fluoxetine can be co-administered without dose adjustment.
Icelandic: Atripla og flúoxetín má gefa samhliða án skammtaaðlögunar.
English: AUC: ↓ 4% (↓ 0 to ↓ 31) Cmax: ↓ 47% (↓ 9 to ↓ 51)
Icelandic: ↓ 47% (↓ 9 til ↓ 51)
English: A summary of resistance mutation development is shown in Table 3.
Icelandic: Samantekt á þróun ónæmisstökkbreytinga má sjá í töflu
English: AUC: ↑ 34% (↑ 18 to ↑ 53) Cmax: ↑ 49% (↑ 32 to ↑ 69)
Icelandic: ↑ 34% (↑ 18 til ↑ 53)
English: ANTI-INFECTIVES HIV antivirals
Icelandic: Veirulyf gegn lifrarbólguveiru
English: CCR5 antagonist Maraviroc/Efavirenz (100 mg b.i.d./600 mg q.d.)
Icelandic: CCR5 blokki Maravírok/efavírenz (100 mg tvisvar sinnum á dag/600 mg einu sinni á dag)
English: The adverse reaction profile of efavirenz, emtricitabine and tenofovir disoproxil in patients co-infected with HIV/HBV or HIV/HCV was similar to that observed in patients infected with HIV without co-infection.
Icelandic: B veiru eða HIV og lifrarbólgu C veiru voru svipaðar og komið hefur í ljós hjá sjúklingum sem sýktir eru af HIV án samhliða sýkingar.
English: AUCinf
Icelandic: Beindrep
English: Didanosine/Tenofovir disoproxil
Icelandic: Dídanósín/tenófóvír tvísóproxíl
English: • chills
Icelandic: • kláði
English: - Other medicines used for HIV infection: The following protease inhibitors: darunavir, indinavir, lopinavir/ritonavir, ritonavir, or ritonavir boosted atazanavir or saquinavir.
Icelandic: Eftirfarandi próteasahemlar: darúnavír, indínavír, lópínavír/rítónavír, rítónavír eða rítónavírstyrkt atazanavír eða saquínavír.
English: It is important to tell your doctor or pharmacist if you are taking any of the following: - Medicines containing didanosine (for HIV infection): Taking Atripla with other antiviral medicines that contain didanosine can raise the levels of didanosine in your blood and may reduce CD4 cell counts.
Icelandic: Ef Atripla er tekið ásamt lyfjum við veirusýkingum sem innihalda dídanósín getur magn dídanósíns í blóði aukist og dregið getur úr CD4 frumufjölda.
English: - Hormonal contraceptive, such as birth control pills, an injected contraceptive (for example, Depo-Provera), or a contraceptive implant (for example, Implanon): You must also use a reliable barrier method of contraception (see Pregnancy and breast-feeding).
Icelandic: - Getnaðarvarnarlyf með hormónum, svo sem getnaðarvarnartöflur, getnaðarvörn á formi stungulyfs (t.d. Depo-Provera) eða vefjalyf (t.d. Implanon):
English: Protease inhibitors
Icelandic: Lyf við mycobakteríum
English: For co-administration of efavirenz with low-dose ritonavir in combination with a protease inhibitor, see section on ritonavir above.
Icelandic: Fyrir samhliða gjöf á efavírenzi og lág-skammta rítónavíri í meðferð með próteasahemli, sjá kaflann um rítónavír hér á undan.
English: Simvastatin:
Icelandic: Efavírenz:
English: Pravastatin/Emtricitabine
Icelandic: Pravastatín/emtricitabín
English: • dizziness, headache, diarrhoea, feeling sick (nausea), being sick (vomiting)
Icelandic: sundl, höfuðverkur, niðurgangur, ógleði, uppköst
English: Boceprevir/Efavirenz (800 mg q8h/600 mg q.d.)
Icelandic: Boceprevír/efavírenz (800 mg á 8 klst. fresti/600 mg einu sinni á dag)
English: Rosuvastatin/Tenofovir disoproxil
Icelandic: Rósúvastatín/tenófovír tvísóproxíl
English: Efavirenz: no clinically significant interaction.
Icelandic: Efavírenz: engar klínískt mikilvægar milliverkanir.
English: Atorvastatin:
Icelandic: Darúnavír:
English: AUC12h: ↔ Cmax: ↔
Icelandic: AUC12h:
English: Antifungals
Icelandic: Emtrícítabín
English: If you are taking any of these medicines, tell your doctor immediately.
Icelandic: Láttu lækninn tafarlaust vita ef þú ert að taka einhver þessara lyfja.
English: Marketing Authorisation Holder:
Icelandic: Nýjasta dagsetning endurnýjunar markaðsleyfis:
English: Treatment group
Icelandic: 14. AFGREIÐSLUTILHÖGUN
English: The following side effects are common (these may affect up to 1 in 10 patients)
Icelandic: Eftirfarandi aukaverkanir eru algengar (þær kunna að koma fyrir hjá allt að 1 af 10 sjúklingum):
English: Atripla and fosamprenavir/ritonavir can be co-administered without dose adjustment.
Icelandic: Atripla og fosamprenavír/rítonavír má gefa samhliða án skammtaaðlögunar.
English: Tenofovir disoproxil
Icelandic: Tenófóvír tvísóproxíl
English: Co-administration of Atripla with sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/ voxilaprevir is not recommended (see section 4.4).
Icelandic: Ekki er mælt með samhliða gjöf Atripla og sófosbúvírs/velpatasvírs eða sófosbúvírs/velpatasvírs/voxílaprevírs (sjá kafla 4.4)
English: AUC: ↓ 83% Cmax: ↓ 87%
Icelandic: ↓ 83% Cmax:
English: The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing this disease.
Icelandic: Nokkrir af mörgum áhættuþáttum þessa sjúkdóms geta verið lengd samsettrar meðferðar gegn retróveirum, notkun barkstera, áfengisneysla, öflug ónæmisbæling og hár líkamsþyngdarstuðull (BMI).
English: Diltiazem/Tenofovir disoproxil
Icelandic: Diltíazem/tenófóvír tvísóproxíl
English: If appropriate, resumption of antihepatitis B therapy may be warranted.
Icelandic: Ef við á má fyrirskipa að meðferð gegn lifrarbólgu
English: Saquinavir/ritonavir/Tenofovir disoproxil There were no clinically significant pharmacokinetic interactions when tenofovir disoproxil was co-administered with ritonavir boosted saquinavir.
Icelandic: Ekki komu fram klínískt marktækar lyfjahvarfa milliverkanir þegar tenófóvír tvísóproxíl var gefið samtímis rítónavírefldu saquínavíri.
English: When the two strata were analysed separately, response rates in the stratum with prior PI-treatment were numerically lower for patients switched to Atripla [92.4% versus 94.0% for the PVR (sensitivity analysis) for Atripla and SBR patients respectively; a difference (95%CI) of -1.6% (-10.0%, 6.7%).
Icelandic: Þegar undirhóparnir tveir voru greindir hvor fyrir sig var svörunarhlutfall hjá undirhópnum sem fékk próteasahemla áður tölulega lægra hjá sjúklingum sem skiptu yfir í Atripla [PVR (næmisgreining) var 92,4% hjá sjúklingum sem fengu
English: Atorvastatin/Tenofovir disoproxil
Icelandic: Atorvastatín/tenófóvír tvísóproxíl
English: Up to 30% of the emtricitabine dose and approximately 10% of the tenofovir dose can be removed by haemodialysis.
Icelandic: Unnt er að fjarlægja allt að 30% af skammtinum af emtrícítabíni og u.þ.b. 10% af skammtinum af tenófóvíri með blóðskiljun.
English: Renal and urinary disorders: Uncommon increased creatinine, proteinuria, proximal renal tubulopathy including Fanconi syndrome
Icelandic: Sjaldgæfar hækkað kreatínín, prótein í þvagi, aðlægur píplukvilli í nýrum þ.m.t. Fanconi heilkenni
English: AUC: ↓ 39% (↓ 30 to ↓ 46) Cmax: ↓ 26% (↓ 15 to ↓ 35)
Icelandic: ↓ 39% (↓ 30 til ↓ 46) Cmax:
English: Indinavir/Efavirenz (800 mg q8h/200 mg q.d.)
Icelandic: Indínavír/efavírenz (800 mg á 8 klst. fresti/200 mg einu sinni á dag)
English: AUC: ↓ 34% (↓ 41 to ↓ 25) Cmax: ↓ 34% (↓ 41 to ↑ 25) Cmin: ↓ 34% (↓ 43 to ↑ 24)
Icelandic: ↓ 34% (↓ 41 til ↑ 25) Cmin:
English: Simvastatin/Tenofovir disoproxil
Icelandic: Simvastatín/tenófóvír tvísóproxíl
English: Vigabatrin/Tenofovir disoproxil Gabapentin/Tenofovir disoproxil
Icelandic: Vígabatrín/tenófóvír tvísóproxíl Gabapentín/tenófóvír tvísóproxíl
English: Dose adjustment of buprenorphine may not be necessary when co-administered with Atripla.
Icelandic: Ekki er víst að þörf sé á skammtaaðlögun búprenorfíns þegar gefið með Atripla
English: (CYP3A4 induction) Efavirenz:
Icelandic: (CYP3A4 örvun) Efavírenz:
English: AUC: ↓ 50% Cmax: ↓ 45%
Icelandic: ↓ 50% Cmax:
English: Tenofovir disoproxil:
Icelandic: N-mónódesmethýl diltíazem:
English: Antimalarials
Icelandic: Lifrarsjúkdómar
English: AUC: ↓ 51% Cmax: ↓ 21%
Icelandic: ↓ 51% Cmax:
English: Atazanavir:
Icelandic: Atazanavír/rítónavír:
English: BATCH NUMBER
Icelandic: B sýkingu.
English: It is indicated for the treatment of human immunodeficiency virus-1 (HIV-1) infection in adults aged 18 years and over with virologic suppression to HIV-1 RNA levels of < 50 copies/ml on their current combination antiretroviral therapy for more than three months.
Icelandic: Lyfið er ætlað til meðferðar á HIV-1 veirusýkingu hjá fullorðnum 18 ára og eldri með veirufræðilega bælingu HIV-1
English: Maraviroc/Tenofovir disoproxil (300 mg b.i.d./245 mg q.d.)
Icelandic: Maravírok/tenófovír tvísóproxíl (300 mg tvisvar sinnum á dag/245 mg einu sinni á dag)
English: Simvastatin/Emtricitabine
Icelandic: Posakónazól/emtricitabín
English: Atripla can reduce the amount of itraconazole or posaconazole in your blood.
Icelandic: Atripla getur dregið úr magni ítrakónazóls eða posakónazóls í blóði.
English: AUC: ↓ 46% Cmax: ↓ 38%
Icelandic: ↓ 46% Cmax:
English: AUC: ↓ 75% (↓ 62 to ↓ 84) Cmax: ↓ 44% (↓ 20 to ↓ 61)
Icelandic: ↓ 75% (↓ 62 til ↓ 84) Cmax:
English: Fluoxetine/Tenofovir disoproxil
Icelandic: Flúoxetín/tenófóvír tvísóproxíl
English: Cmax: ↓ 64% (↓ 57 to ↓ 69) Cmin: ↓ 62% (↓ 44 to ↓ 75)
Icelandic: ↓ 64% (↓ 57 til ↓ 69) Cmin:
English: - Medicines used to treat bacterial infections, including tuberculosis and AIDS-related mycobacterium avium complex: Clarithromycin, rifabutin, rifampicin.
Icelandic: - Lyf til meðferðar við bakteríusýkingum, að meðtalinni berkla og alnæmistengdri mycobacterium avium complex:
English: Your doctor may give you a different anticonvulsant.
Icelandic: Verið getur að læknirinn ávísi annars konar krampastillandi lyfi.
English: Gastrointestinal disorders: Very common diarrhoea, nausea diarrhoea, vomiting, nausea
Icelandic: Mjög algengar niðurgangur, ógleði niðurgangur, uppköst, ógleði
English: Patients with HIV and hepatitis B (HBV) or C virus (HCV) co-infection Patients with chronic hepatitis B or C and treated with CART are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Icelandic: B eða C sem fá CART eru í aukinni hættu á að fá alvarlegar og hugsanlega lífshættulegar aukaverkanir á lifur.
English: AUC: ↓ 55% (↓ 48 to ↓ 62) Cmax: ↓ 34% (↓ 21 to ↓ 47)
Icelandic: ↓ 55% (↓ 48 til ↓ 62) Cmax:
English: Rifampicin/Emtricitabine
Icelandic: Rífabútín/emtricitabín
English: Lopinavir/ritonavir/Emtricitabine
Icelandic: Fosamprenavír/rítonavír/ emtricitabín
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING
Icelandic: Atripla sem aukaverkanirnar eru raktar til, í eftirfarandi töflu
English: Buprenorphine/naloxone/Tenofovir disoproxil
Icelandic: Efavírenz/emtrícítabín/ tenófóvír tvísóproxíl
English: AUC12h: ↓ 45% (↓ 38 to ↓ 51) Cmax: ↓ 51% (↓ 37 to ↓ 62)
Icelandic: ↓ 45% (↓ 38 til ↓ 51)
English: Symptoms including, but not limited to, dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming are frequently reported undesirable effects in patients receiving efavirenz 600 mg daily in clinical studies.
Icelandic: 600 mg af efavírenzi á dag í klínískum rannsóknum voru meðal annars sundl, svefnleysi, svefndrungi, skert einbeiting og óeðlilegir draumar (ekki tæmandi upptalning).
English: In patients with a history of renal dysfunction or in patients who are at risk of renal dysfunction, a more frequent monitoring of renal function is required.
Icelandic: Tíðara eftirlit þarf með nýrnastarfsemi hjá sjúklingum með sögu um starfstruflun í nýrum eða sjúklingum sem eiga slíka starfstruflun á hættu.
English: HORMONAL CONTRACEPTIVES Oral:
Icelandic: Lyf til meðferðar við malaríu:
English: Atazanavir/ritonavir/Tenofovir disoproxil (300 mg q.d./100 mg q.d./245 mg q.d.)
Icelandic: Darúnavír/rítonavír/tenófovír tvísóproxíl (300 mg tvisvar sinnum á dag*/100 mg tvisvar sinnum á dag/245 mg einu sinni á dag)
English: Atazanavir/ritonavir/Efavirenz (400 mg q.d./100 mg q.d./600 mg q.d., all administered with food)
Icelandic: Atazanavír/ritonavír/efavírenz (400 mg einu sinni á dag/100 mg einu sinni á dag/600 mg einu sinni á dag, allt gefið með mat)
English: Table 2: Adverse reactions associated with Atripla listed by the component(s) of Atripla to which the adverse reactions are attributable
Icelandic: Aukaverkanir í tengslum við Atripla flokkaðar eftir þeim virku innihaldsefnum
English: AUC: ↓ 52% (↓ 33 to ↓ 66) Cmax: ↓ 45% (↓ 25 to ↓ 59)
Icelandic: ↓ 52% (↓ 33 til ↓ 66) Cmax:
English: Atripla and valproic acid can be co-administered without dose adjustment.
Icelandic: Atripla og valpróínsýru má gefa samhliða án skammtaaðlögunar.
English: AUC: ↓ 71% (↓ 67 to ↓ 74) Cmax: ↓ 51% (↓ 46 to ↓ 56) Cmin: ↓ 91% (↓ 88 to ↓ 92)
Icelandic: ↓ 71% (↓ 67 til ↓ 74) Cmax:
English: AUC: ↓ 69% (↓ 55 to ↓ 79) Cmax: ↓ 60% (↓ 50 to ↓ 68) Cmin: ↓ 63% (↓ 44 to ↓ 75)
Icelandic: ↓ 69% (↓ 55 til ↓ 79) Cmax:
English: • increased cholesterol in the blood
Icelandic: • aukið kólesteról í blóði
English: Pravastatin/Efavirenz (40 mg q.d./600 mg q.d.)
Icelandic: Pravastatín/efavírenz (40 mg einu sinni á dag/600 mg einu sinni á dag)
English: See ritonavir row below.
Icelandic: Sjá rítonavír dálk hér á eftir.
English: Lopinavir/ritonavir/Tenofovir disoproxil (400 mg b.i.d./100 mg b.i.d./245 mg q.d.)
Icelandic: Lópínavír/rítónavír/Tenófóvír tvísóproxíl (400 mg tvisvar sinnum á dag/100 mg tvisvar sinnum á dag/245 mg einu sinni á dag)
English: In order to improve the tolerability to efavirenz with respect to undesirable effects on the nervous system, bedtime dosing is recommended (see section 4.8).
Icelandic: Mælt er með því að gefa lyfið fyrir svefn að kvöldi til að draga úr líkum á óæskilegum aukaverkunum á taugakerfið (sjá kafla 4.8).
English: Saquinavir/ritonavir/Efavirenz
Icelandic: Saquínavír/rítónavír/efavírenz
English: AUC: ↓ 39% (↓ 21 to ↓ 53) Cmax: ↓ 37% (↓ 20 to ↓ 51) Cmin: ↓ 44% (↓ 27 to ↓ 58)
Icelandic: ↓ 37% (↓ 20 til ↓ 51) Cmin:
English: AUC: ↑ 21% (↑ 10 to ↑ 34) Cmax: ↑ 14% (↑ 4 to ↑ 26) Cmin: ↑ 25% (↑ 7 to ↑ 46)
Icelandic: ↑ 14% (↑ 4 til ↑ 26) Cmin:
English: Emtricitabine
Icelandic: Brjóstagjöf