FrancophonIA/ELRC3.0 huggingface dataset:
English: • Probenecid may interact with other medicines commonly used in the treatment of AIDS and AIDS-related illnesses, such as zidovudine (AZT).
Slovenian: • Probenecid ima lahko medsebojne učinke z drugimi zdravili, ki se pogosto uporabljajo za zdravljenje AIDS-a in z AIDS-om povezanih bolezni, npr. z zidovudinom (AZT).
English: The safety and efficacy of Vistide have not been established in patients with hepatic disease and therefore it should be used with caution in this patient population.
Slovenian: Varnost in učinkovitost zdravila Vistide pri bolnikih z boleznijo jeter nista bili dokazani, zato ga je treba pri tej populaciji bolnikov uporabljati previdno.
English: If visible particles or discolouration are observed, the vial should not be used.
Slovenian: Če so opazni vidni delci ali obarvanje, se takšne viale ne sme uporabiti.
English: Use of cidofovir without concomitant probenecid has not been clinically investigated.
Slovenian: Uporaba cidofovira brez sočasne uporabe probenecida klinično ni raziskana.
English: If you can tolerate the additional fluid load, your doctor may administer a second litre of fluid.
Slovenian: Če prenesete dodatno obremenitev s tekočino, vam zdravnik lahko da še drugi liter tekočine.
English: The safety and efficacy of Vistide in children below 18 years of age have not been established.
Slovenian: Varnost in učinkovitost zdravila Vistide pri otrocih, mlajših od 18 let nista bili dokazani.
English: • aminoglycosides, pentamidine or vancomycin (for bacterial infections)
Slovenian: • aminoglikozide, pentamidin ali vankomicin (za bakterijske okužbe)
English: It must not be administered by other methods including intraocular injection (direct injection into the eye) or topically (on the skin).
Slovenian: Ne sme se ga dati na drugačen način, vključno z intraokularnim injiciranjem (injicirati neposredno v oko) ali zunanje (na kožo).
English: Probenecid is only taken on the same day that Vistide is given.
Slovenian: Probenecid se vzame samo na isti dan, kot se da zdravilo Vistide.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/97/037/001
Slovenian: ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/97/037/001
English: The formulation is pH-adjusted with sodium hydroxide (and hydrochloric acid if needed) and contains no preservatives.
Slovenian: Pripravek ima pH uravnan z natrijevim hidroksidom (in klorovodikovo kislino, če je potrebno) in ne vsebuje konzervansov.
English: Do not use Vistide after the expiry date which is stated on the label.
Slovenian: Zdravila Vistide ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini.
English: Direct intraocular injection of Vistide is contraindicated; direct injection may be associated with significant decreases in intraocular pressure and impairment of vision.
Slovenian: Neposredno intraokularno injiciranje zdravila Vistide je kontraindicirano; neposredno injiciranje lahko spremljata pomembno znižanje očesnega tlaka in okvara vida.
English: • If you cannot take the medicine probenecid because of a serious allergy to probenecid or other sulfa-containing medicines (e.g. sulfamethoxazole).
Slovenian: • Če ne morete jemati zdravila probenecid, ker imate resno alergijo na probenecid ali druga zdravila, ki vsebujejo žveplo (npr. sulfametoksazol).
English: 1 vial 375 mg/5 ml
Slovenian: 1 viala 375 mg/5 ml
English: • The potential for interactions between Vistide and anti-HIV protease inhibitors has not been studied.
Slovenian: • Možni medsebojni učinki med zdravilom Vistide in zaviralci proteaz proti HIV niso raziskani.
English: For those patients who fully recover from cidofovir associated renal toxicity, the benefits-risk balance of reintroducing cidofovir has not yet been evaluated.
Slovenian: Za tiste bolnike, ki popolnoma okrevajo po okvari ledvic, ki jo je povzročil cidofovir, razmerje med koristjo in tveganji pri ponovni uvedbi cidofovira še ni raziskano.
English: In both cases, the overdose occurred during the first induction dose and no additional cidofovir therapy was administered.
Slovenian: V obeh primerih je do prevelikega odmerjanja prišlo med prvim začetnim odmerkom in nadaljnja terapija s cidofovirom ni bila uporabljena.
English: Chemical and physical in-use stability has been demonstrated for up to 24 hours at 2 - 8ºC when dilution is performed under controlled and validated aseptic conditions.
Slovenian: Kemična in fizikalna stabilnost med uporabo sta dokazani za 24 ur pri temperaturi od 2-8°C, če je bila raztopitev izvedena pod kontroliranimi in validiranimi aseptičnimi pogoji.
English: Your doctor may also instruct you to drink plenty of fluids.
Slovenian: Zdravnik vam bo morda tudi naročil, da pijte veliko tekočin.
English: • During treatment with Vistide you should receive regular follow-up eye examinations for possible eye irritation, inflammation or swelling.
Slovenian: • Med zdravljenjem z zdravilom Vistide morate redno opravljati preglede oči zaradi morebitnega draženja, vnetja ali otekanja oči.
English: Sodium hydroxide Hydrochloric acid Water for injections
Slovenian: natrijev hidroksid klorovodikova kislina voda za injekcije
English: The recommended dose, frequency of use, or rate of infusion must not be exceeded.
Slovenian: Ne sme se preseči priporočenega odmerka, pogostnosti uporabe in hitrosti infundiranja.
English: Vistide should be used only when other agents are considered unsuitable.
Slovenian: Zdravilo Vistide naj bi uporabljali le, če druga zdravila niso primerna.
English: Vistide is formulated for intravenous infusion only and must not be administered by other methods including intraocular injection or topically.
Slovenian: Zdravilo Vistide je formulirano samo za intravensko infundiranje in se ne sme uporabljati na noben drugačen način, vključno z intraokularnim injiciranjem ali zunanje.
English: Nausea, vomiting
Slovenian: Navzea, bruhanje
English: The major route of elimination of cidofovir was by renal excretion of unchanged drug by a combination of glomerular filtration and tubular secretion.
Slovenian: Glavna pot izločanja cidofovira je bilo ledvično izločanje nespremenjenega zdravila s kombinacijo glomerulne filtracije in tubulne sekrecije.
English: Vistide will not stop you passing HIV infection onto other people so you should continue to take precautions to avoid infecting
Slovenian: Zdravilo Vistidine ne bo preprečilo prenosa okužbe na druge ljudi, zato morate nadaljevati z ustreznimi previdnostnimi ukrepi, da ne okužite drugih.
English: If you drive or operate machinery, discuss this with your doctor to get their advice about stopping these activities based upon your disease and your tolerance of the medicine.
Slovenian: Če vozite ali upravljate s stroji, se posvetujte z zdravnikom o prekinitvi dejavnosti glede na vašo bolezen in vaše prenašanje zdravila.
English: However, in case of difficulty in obtaining probenecid the local representative of the Marketing Authorisation Holder of Vistide should be contacted for information (see also sections 4.2 and 4.4).
Slovenian: V primeru težav z dobavo probenecida pa se je mogoče za informacije obrniti na lokalnega predstavnika imetnika dovoljenja za promet z zdravilom Vistide (glejte tudi poglavji 4.2 in 4.4).
English: What Vistide looks like and contents of the pack
Slovenian: Izgled zdravila Vistide in vsebina pakiranja
English: Iritis, uveitis, hypotony of the eye (see section 4.4)
Slovenian: Iritis, uveitis, hipotonija očesa (glejte poglavje 4.4)
English: Cases of acute renal failure have been reported after only one or two doses of cidofovir.
Slovenian: Opisani so primeri akutne odpovedi ledvic po le enem ali dveh odmerkih cidofovirja.
English: There have been reports of reduced white blood counts, liver toxicity, kidney toxicity and destruction of red blood cells.
Slovenian: Poročali so o znižanem številu belih krvnih celic, jetrni toksičnosti, ledvični toksičnosti in propadu rdečih krvnih celic.
English: Blood and lymphatic system disorders Very common
Slovenian: Bolezni krvi in limfatičnega sistema Zelo pogosti
English: Maintenance treatment.
Slovenian: Vzdrževalno zdravljenje.
English: Proteinuria appears to be an early and sensitive indicator of cidofovir-induced nephrotoxicity.
Slovenian: Kaže, da je proteinurija zgoden in občutljiv kazalec nefrotoksičnih učinkov cidofovira.
English: There are no data from the use of cidofovir in pregnant women.
Slovenian: Podatkov o uporabi cidofovira pri nosečnicah ni.
English: If you are taking zidovudine, you should discuss with your doctor whether to temporarily stop taking zidovudine or decrease the dose of zidovudine by 50% on days when Vistide and probenecid are given.
Slovenian: Če jemljete zidovudin, se morate z zdravnikom posvetovati, ali naj začasno prekinete uporabo zidovudina ali pa ob dneh, ko dobite zdravilo Vistide in probenecid, zmanjšate odmerek zidovudina za 50%.
English: It is recommended to discontinue potentially nephrotoxic agents at least 7 days before starting cidofovir.
Slovenian: Zdravljenje s potencialno nefrotoksičnimi sredstvi je priporočljivo opustiti vsaj 7 dni pred začetkom zdravljenja s cidofovirom.
English: Not known
Slovenian: Neznano
English: CMV attacks the retina of the eye and may cause loss of vision, and eventually lead to blindness.
Slovenian: CMV napade očesno mrežnico in lahko povzroči poslabšanje vida in končno tudi s slepoto.
English: Refrigerated infusion bags should be allowed to warm to room temperature prior to use.
Slovenian: Ohlajene infuzijske vrečke je treba pustiti, da se pred uporabo ogrejejo na sobno temperaturo.
English: Peri- and post-natal development studies in which female rats received subcutaneous injections of cidofovir once daily at doses up to 1.0 mg/kg/day from day 7 of gestation through day 21 postpartum (approximately 5 weeks) resulted in no adverse effects on viability, growth, behaviour, sexual maturation or reproductive capacity in the offspring.
Slovenian: Peri- in postnatalne razvojne študije, v katerih so podganje samice enkrat na dan dobivale subkutane injekcije cidofovira v odmerkih do 1,0 mg/kg/dan, in sicer od 7. dne gestacije do 21. postpartalnega dneva (približno 5 tednov), niso pokazale nobenih neželenih učinkov na sposobnost za življenje mladičev, njihovo rast, vedenje, spolno dozorevanje ali reprodukcijsko zmožnost.
English: Patients receiving both drugs should be closely monitored for zidovudine induced haematological toxicity.
Slovenian: Bolnike, ki jemljejo obe zdravili, je treba skrbno opazovati glede hematološke toksičnosti, ki jo povzroča zidovodin.
English: Adverse reactions possibly or probably related to cidofovir based on clinical trial experience and post-marketing surveillance
Slovenian: Neželeni učinki, morda ali verjetno povezani s cidofovirjem na podlagi kliničnih preskušanj in pomarketinškega spremljanja
English: Cidofovir diphosphate inhibits these viral polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerases alpha, beta, and gamma.
Slovenian: Cidofovirdifosfat zavre te virusne polimeraze v koncentracijah, ki so od 8- do 600-krat nižje od koncentracij, potrebnih za zavrtje DNA polimeraz alfa, beta in gama v človeških celicah.
English: Renal insufficiency [creatinine clearance ≤ 55 ml/min or ≥ 2+ proteinuria (≥ 100 mg/dl)] is a contraindication for the use of Vistide (see sections 4.3 and 4.4).
Slovenian: Ledvična insuficienca [očistek kreatinina ≤ 55 ml/min ali proteinurija ≥ 2+ (≥ 100 mg/dl)] je kontraindikacija za uporabo zdravila Vistide (glejte poglavji 4.3 in 4.4).
English: If Vistide contacts the skin, wash membranes and flush thoroughly with water.
Slovenian: Če pride zdravilo Vistide v stik s kožo, jo je treba umiti in temeljito splakniti z vodo.
English: The therapy should be prescribed by a physician experienced in the management of HIV infection.
Slovenian: Zdravljenje mora predpisati zdravnik, ki ima izkušnje z vodenjem okužbe s HIV.
English: Vistide will not cure CMV retinitis but may improve your condition by delaying progression of the disease.
Slovenian: Zdravilo Vistide citomegalovirusnega retinitisa ne ozdravi, lahko pa izboljša stanje, ker upočasni napredovanje bolezni.
English: If you have accidentally been given more Vistide than prescribed for you, tell your doctor immediately.
Slovenian: Če ste pomotoma prejeli večji odmerek zdravila Vistide, kot vam je bil predpisan, to nemudoma povejte zdravniku.
English: Allergic reactions, with skin inflammation, itching, hives and, rarely, severe allergic reactions, and serious skin reaction have occurred.
Slovenian: Prišlo je do alergijskih reakcij z vnetjem kože, srbenjem in koprivnico; redko je prišlo tudi do hudih alergijskih reakcij in hudih kožnih reakcij.
English: Therefore before giving you probenecid your doctor should consult the current prescribing information regarding the safety of probenecid.
Slovenian: Preden vam predpiše probenecid, mora vaš zdravnik za dodatne podatke o varnosti preveriti veljavne informacije o varnosti probenecida.
English: At the 4 cidofovir levels (12.5 to 100 µg/ml) tested, the percentage of damaged metaphases and number of aberrations per cell increased in a concentrationdependent manner.
Slovenian: Pri 4 raziskanih koncentracijah cidofovira (od 12,5 do 100 µg/ml) sta odstotek okvarjenih metafaz in število aberacij na celico naraščala od koncentracije odvisno.
English: Women of childbearing potential have to use effective contraception during and after treatment with cidofovir.
Slovenian: Ženske v rodni dobi morajo uporabljati učinkovito kontracepcijo med zdravljenjem s cidofovirom in po njem.
English: Renal insufficiency/Haemodialysis
Slovenian: Insuficienca ledvic/hemodializa
English: The in vitro sensitivity to cidofovir is shown in the following table:
Slovenian: Občutljivost za cidofovir in vitro prikazuje naslednja preglednica:
English: In vitro protein binding
Slovenian: Vezava na beljakovine in vitro
English: Patients receiving cidofovir must have their serum creatinine and urine protein levels determined on specimens obtained within 24 hours prior to the administration of each dose of cidofovir.
Slovenian: Pri bolnikih, ki dobivajo cidofovir, je treba koncentracijo kreatinina v serumu in beljakovin v urinu določiti v vzorcih, dobljenih v 24 urah pred vsakim odmerkom cidofovira.
English: How to take probenecid with Vistide
Slovenian: Kako jemati probenecid z zdravilom Vistide
English: Vistide must be given by a doctor or nurse with appropriate experience in treating people with AIDS.
Slovenian: Zdravilo Vistide mora dati zdravnik ali medicinska sestra z ustreznimi izkušnjami v zdravljenju bolnikov z AIDS-om.
English: It is unknown whether cidofovir/metabolites are excreted in human milk.
Slovenian: Ni znano, ali se cidofovir/presnovki izločajo v materino mleko.
English: High flux haemodialysis has been shown to reduce the serum levels of cidofovir by approximately 75%.
Slovenian: Dokazano je, da visokopretočna hemodializa zmanjša koncentracijo cidofovira v serumu za približno 75%.
English: All clinical trials relevant to clinical efficacy evaluation were performed using probenecid concomitantly with cidofovir.
Slovenian: V vseh kliničnih preizkušanjih, pomembnih za oceno klinične učinkovitosti, so sočasno s cidofovirom uporabljali probenecid.
English: In vitro protein binding of cidofovir to plasma or serum protein was 10% or less over the cidofovir concentration range 0.25 to 25 µg/ml.
Slovenian: Vezava cidofovira na beljakovine v plazmi ali serumu in vitro je bila v koncentracijskem območju od 0,25 do 25 µg/ml cidofovira 10% ali manj.
English: Treatment with Vistide must not be initiated in patients with creatinine clearance ≤ 55 ml/min, or ≥ 2+ proteinuria (≥ 100 mg/dl), as the optimum induction and maintenance doses for patients with moderate to severe renal impairment are not known.
Slovenian: Zdravljenja z zdravilom Vistide se ne sme začeti pri bolnikih, ki imajo očistek kreatinina ≤ 55 ml/min ali proteinurijo ≥ 2+ (≥ 100 mg/dl), ker optimalni začetni in vzdrževalni odmerki za bolnike z zmerno do hudo okvaro ledvic niso znani.
English: If you become pregnant while receiving this medication, you must inform your doctor immediately.
Slovenian: Če zanosite med uporabo tega zdravila, morate nemudoma obvestiti zdravnika.
English: See the package leaflet for further information.
Slovenian: Za nadaljne informacije glejte navodilo za uporabo.
English: Probenecid tablets are given to lower the risk of kidney damage.
Slovenian: Tablete probenecida se uporabljajo za zmanjšanje tveganja okvare ledvic.
English: In patients exhibiting ≥ 2+ proteinuria, intravenous hydration should be performed and the test repeated.
Slovenian: Pri bolnikih s proteinurijo ≥ 2+ je treba opraviti intravensko hidracijo in preiskavo ponoviti.
English: Refrigerated solutions should be allowed to warm to room temperature prior to use.
Slovenian: Ohlajeno raztopino je treba pustiti, da se pred uporabo ogreje na sobno temperaturo.
English: In patients with normal renal function, 80 to 100% of the intravenous dose was recovered in the urine over 24 hours as unchanged cidofovir.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic se je v 24 urah od 80 do 100-odstotnega intravenskega odmerka izločilo v urinu kot nespremenjeni cidofovir.
English: Patients receiving cidofovir should be advised to have regular follow-up ophthalmologic examinations for possible occurrence of uveitis/iritis and ocular hypotony.
Slovenian: Bolnikom, ki dobivajo cidofovir, je treba svetovati, naj redno opravljajo oftalmološke preglede zaradi morebitnega pojava uveitisa/iritisa in očesne hipotonije.
English: To reduce the risk of kidney damage, you will receive intravenous fluids (normal saline) before each dose of Vistide and probenecid tablets before and after each dose of Vistide (see section 3 below for more information).
Slovenian: Da bi zmanjšali tveganje za okvaro ledvic, boste dobili intravensko tekočino (fiziološko raztopino) pred vsakim odmerkom zdravila Vistide in tablete probenecida pred in po vsakem odmerku zdravila Vistide (glejte poglavje 3 spodaj za več informacij).
English: Should not be administered by intraocular injection.
Slovenian: Ne sme se uporabljati za intraokularno injiciranje.
English: The safety of cidofovir has not been evaluated in patients receiving other known potentially nephrotoxic agents (e.g. tenofovir, aminoglycosides, amphotericin B, foscarnet, intravenous pentamidine, adefovir and vancomycin).
Slovenian: Varnost cidofovira ni ugotovljena pri bolnikih, ki dobivajo druge potencialno nefrotoksične učinkovine (npr. tenofovir, aminoglikozide, amfotericin B, foskarnet, intravenski pentamidin, adefovir in vankomicin).
English: Probenecid may also cause other side effects including loss of appetite, sore gums, flushing, hair loss, dizziness, reduced red blood cell count and increased frequency of passing water (urinating).
Slovenian: Probenecid lahko povzroči tudi druge neželene učinke, kot so izguba apetita, boleče dlesni, zardevanje, izpadanje las, omotica, znižano število rdečih krvnih celic in večja pogostost odvajanja vode (uriniranja).
English: 5 ml clear glass vials with a 5 ml nominal fill volume.
Slovenian: 5 ml viale iz prozornega stekla za enkratno uporabo, s 5 ml nominalnega polnilnega volumna.
English: Hypersensitivity reactions, with dermatitis, pruritus, urticaria and, rarely, anaphylaxis, and Stevens-Johnson syndrome have occurred.
Slovenian: Pojavile so se preobčutljivostne reakcije z dermatitisom, srbenjem, urtikarijo in, redko, anafilaksijo in Stevens-Johnsonovim sindromom.
English: Two cases of cidofovir overdose have been reported.
Slovenian: Opisana sta dva primera prevelikega odmerjanja cidofovira.
English: Preclinical animal studies demonstrated that nephrotoxicity was the major dose-limiting toxicity of cidofovir.
Slovenian: Predklinične študije na živalih so pokazale, da so nefrotoksični učinki glavni toksični pojavi, ki omejujejo odmerek cidofovira.
English: Probenecid is known to increase the exposure of many substances (e.g., paracetamol, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicyclic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).
Slovenian: Znano je, da probenecid zveča izpostavljenost številnim zdravilom (npr. paracetamolu, acikloviru, zaviralcem angiotenzinske konvertaze, aminosalicilni kislini, barbituratom, benzodiazepinom, bumetanidu, klofibratu, metotreksatu, famotidinu, furosemidu, nesteroidnim protivnetnim zdravilom, teofilinu in zidovudinu).
English: The preparation of Vistide diluted solution should be done in a laminar flow biological safety cabinet.
Slovenian: Raztopino zdravila Vistide je treba pripraviti v biološkem varnostnem sistemu z laminarnim pretokom.
English: Cidofovir enters cells by fluid-phase endocytosis and is phosphorylated to cidofovir monophosphate and subsequently to cidofovir diphosphate.
Slovenian: Cidofovir vstopi v celice z endocitozo tekoče faze ter se fosforilira v cidofovirmonofosfat in nato v cidofovirdifosfat.
English: If you get pain, redness or itching of the eye or changes in your vision, tell your doctor promptly.
Slovenian: Če dobite bolečino, pordelost ali srbenje oči ali spremembe vida, nemudoma obvestitite svojega zdravnika.
English: Any pain, redness or itching of the eye or changes in your vision should be promptly reported to your doctor so that your treatment can be reviewed.
Slovenian: Za vsako bolečino, pordelost ali srbenje oči in za vsako spremembo vida morate takoj povedati zdravniku, da bo lahko pretehtal vaše zdravljenje.
English: Your doctor might instruct you to take other medicines such as anti-emetics (anti sickness medicines), antihistamines and/or paracetamol to decrease the side effects of probenecid.
Slovenian: Vaš zdravnik vam lahko naroči, da za ublažitev neželenih učinkov probenecida uporabite še druga zdravila, npr. antiemetike (zdravila proti slabosti), antihistaminike in/ali paracetamol.
English: SPECIAL STORAGE CONDITIONS Do not store above 30°C.
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi do 30°C.
English: Prolonged antiviral effects of cidofovir are related to the half-lives of its metabolites; cidofovir diphosphate persists inside cells with a half-life of 17-65 hours and a cidofovir phosphate-choline adduct has a half-life of 87 hours.
Slovenian: Podaljšano protivirusno učinkovanje cidofovira je povezano z razpolovnimi časi njegovih presnovkov; cidofovirdifosfat ostane v notranjosti celic z razpolovnim časom od 17 do 65 ur; adukt cidofovirfosfat-holin ima razpolovni čas 87 ur.
English: In patients who develop allergic or hypersensitivity symptoms to probenecid (e.g., rash, fever, chills and anaphylaxis), prophylactic or therapeutic use of an appropriate antihistamine and/or paracetamol should be considered.
Slovenian: Pri bolnikih, ki doživijo simptome alergije ali preobčutljivosti za probenecid (npr. izpuščaj, zvišana telesna temperatura, mrzlica in anafilaksija), je treba razmisliti o profilaktični ali terapevtski uporabi antihistaminika in/ali paracetamola.
English: Dilute before use.
Slovenian: Pred uporabo raztopite.
English: Ear and labyrinth disorders Not known
Slovenian: Ušesne bolezni, vključno z motnjami labirinta Neznano
English: There are no studies of cidofovir on the fertility of men or women.
Slovenian: Ni študij o vplivu cidofovira na sposobnost razmnoževanja moških ali žensk.
English: Excess Vistide and all other materials used in the admixture preparation and administration should be placed in a leak-proof, puncture-proof container for disposal.
Slovenian: Ostanke zdravila Vistide in vseh drugih materialov, ki se uporabljajo za pripravo in apliciranje mešanice, je treba dati v neprepusten, proti vbodom varen vsebnik za odlaganje.
English: Personnel preparing the solution should wear surgical gloves, safety glasses and a closed front surgical-type gown with knit cuffs.
Slovenian: Osebje, ki pripravlja raztopino, mora nositi kirurške rokavice, varnostna očala in spredaj zaprto kirurško haljo s stisnjenimi manšetami.