FrancophonIA/ELRC3.0 huggingface dataset:
English: • Discolouration of the skin on the face or other parts of the body
Slovenian: • obarvanje kože na obrazu ali drugih delih telesa;
English: DUAVIVE is used for:
Slovenian: Zdravilo DUAVIVE se uporablja za:
English: Women should be advised what changes in their breasts should be reported to their doctor or nurse (see ‘Breast cancer' below).
Slovenian: Ženskam je treba svetovati, o katerih spremembah na dojkah morajo poročati zdravniku ali medicinski sestri (glejte »Rak dojke« spodaj).
English: Serious venous thromboembolic events may occur rarely (less than 1 case per 1,000 patients).
Slovenian: Redko se lahko pojavijo resni venski trombembolični dogodki (manj kot 1 primer na 1.000 bolnic).
English: No foetal developmental anomalies were observed.
Slovenian: Razvojnih anomalij plodov niso opazili.
English: EU/1/14/960/001 28 tablets
Slovenian: EU/1/14/960/001 28 tablet
English: You can take the tablet at any time of the day, with or without food; however, it is advisable to take your tablet at the same time each day as this will help to remind you to take your medicine.
Slovenian: Tableto lahko vzamete kadarkoli v dnevu, s hrano ali brez nje, priporočamo pa, da jo vzamete vsak dan ob istem času, saj si boste tako lažje zapomnili, da jo morate vzeti.
English: This might lead to irregular bleeding.
Slovenian: To lahko privede do neobičajne krvavitve.
English: This may include an examination of your breasts and/or an internal examination, if necessary, or if you have any special concerns.
Slovenian: Morda se bo odločil opraviti telesni pregled, ki lahko vključuje pregled dojk in/ali notranji pregled, če je potreben, ali če imate kakršnekoli posebne skrbi.
English: • drinking too much alcohol
Slovenian: • pretirano pitje alkohola;
English: Tmax (hr)
Slovenian: tmax (h)
English: If you feel drowsy after taking this medicine, you should avoid driving or operating machines.
Slovenian: Če po jemanju tega zdravila občutite dremavost, se morate izogibati vožnji ali upravljanju strojev.
English: You will only be prescribed this medicine if your symptoms seriously hinder your daily life and your doctor determines that other types of HRT are not appropriate for you.
Slovenian: To zdravilo vam bodo predpisali samo, če vas simptomi resno ovirajo pri vsakdanjem življenju in če vaš zdravnik ugotovi, da druge oblike hormonskega nadomestnega zdravljenja (HNZ) za vas niso primerne.
English: • migraine-like headaches which happen for the first time
Slovenian: • glavobole, podobne migreni, ki se pojavijo prvič;
English: Investigations, including appropriate imaging tools, e.g., mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual.
Slovenian: Preiskave, vključno s slikanjem z ustreznimi orodji (npr. mamografijo), je treba opraviti skladno s trenutno veljavno prakso za presejalne preglede, prilagojeno kliničnim potrebam posameznice.
English: • if you have systemic lupus erythematosus (SLE).
Slovenian: • če imate sistemski eritematozni lupus (SLE);
English: The use of DUAVIVE carries risks, which need to be considered when deciding whether to start taking it, or whether to carry on taking it.
Slovenian: Uporaba zdravila DUAVIVE vključuje tveganja, ki jih je treba upoštevati pri odločitvi, ali boste začeli jemati to zdravilo in ali boste jemanje nadaljevali.
English: CE/BZA was evaluated in 4,868 post-menopausal women who participated in 5 phase 3 trials.
Slovenian: Kombinacijo CE/BZA so ocenjevali pri 4.868 ženskah v postmenopavzi, ki so sodelovale v 5 preskušanjih 3. faze.
English: Stop taking DUAVIVE and see a doctor immediately
Slovenian: Prenehajte jemati zdravilo DUAVIVE in takoj obiščite zdravnika
English: If you forget to take a tablet, take it as soon as you remember.
Slovenian: Če pozabite vzeti tableto, jo vzemite takoj, ko se spomnite.
English: • if you have any blood clotting problem that needs long-term treatment with a medicine used to prevent blood clots
Slovenian: • če imate kakršnokoli težavo s strjevanjem krvi, ki zahteva dolgotrajno zdravljenje z zdravilom za preprečevanje krvnih strdkov;
English: • if you are unable to walk for a long time because of major surgery, injury or illness (see also section 3, if you need to have surgery)
Slovenian: • če niste zmožni daljše hoje zaradi večjega kirurškega posega, poškodbe ali bolezni (glejte tudi poglavje 3 »Če vam bodo opravili kirurški poseg«);
English: Pfizer Ireland Pharmaceuticals, Little Connell, Newbridge, County Kildare, Ireland.
Slovenian: Proizvajalec Pfizer Ireland Pharmaceuticals, Little Connell Newbridge, County Kildare, Irska.
English: During these check-ups, discuss with your doctor the benefits and risks of continuing with DUAVIVE.
Slovenian: Pri teh pregledih se z zdravnikom posvetujte o koristih in tveganjih nadaljevanja jemanja zdravila DUAVIVE.
English: Some medicines may interfere with the effect of DUAVIVE.
Slovenian: Nekatera zdravila lahko vplivajo na učinek zdravila DUAVIVE.
English: • any of the conditions mentioned under ‘Do not take DUAVIVE'
Slovenian: • katerokoli bolezen, omenjeno v poglavju »Ne jemljite zdravila DUAVIVE«;
English: Food had little or no effect on the exposure of CE.
Slovenian: Hrana je imela majhen vpliv ali sploh ni imela vpliva na izpostavljenost CE.
English: The major route of excretion of radiolabeled BZA is the faeces, and less than 1% of the dose is eliminated in urine.
Slovenian: Glavna pot izločanja radioaktivno označenega BZA je blato, manj kot 1 % odmerka pa se izloči z urinom.
English: The concentrations of this glucuronide are approximately 10-fold higher than those of unchanged BZA in plasma.
Slovenian: Koncentracije tega glukuronida so približno 10-krat večje kot koncentracije nespremenjenega BZA v plazmi.
English: Longterm exposure to CE/BZA for up to 2 years was evaluated; 3,322 women were exposed to CE/BZA for at least 1 year, and 1,999 women were exposed for 2 years.
Slovenian: Ocenili so dolgotrajno izpostavljenost CE/BZA, ki je trajala do 2 leti; 3.322 žensk je bilo izpostavljenih kombinaciji CE/BZA najmanj 1 leto, 1.999 žensk pa je bilo izpostavljenih 2 leti.
English: During the menopause, the amount of the oestrogen produced by a woman's body drops.
Slovenian: Med menopavzo se količina estrogena, ki ga proizvaja telo, zmanjša.
English: The level of risk is dependent on duration of use (see section 4.4).
Slovenian: Stopnja tveganja je odvisna od trajanja uporabe (glejte poglavje 4.4).
English: If this happens, you should avoid driving or operating machines until your doctor tells you that it is safe to do so.
Slovenian: Če se to zgodi, se morate izogibati vožnji ali upravljanju strojev, dokler vam zdravnik ne pove, da je to varno.
English: Oestrogen therapy will not prevent memory loss.
Slovenian: Zdravljenje z estrogenom ne preprečuje izgube spomina.
English: - Porphyria.
Slovenian: - Porfirija.
English: It is not known whether bazedoxifene is excreted in human milk.
Slovenian: Ni znano, ali se bazedoksifen izloča v materino mleko.
English: Negligible (1%) amounts of BZA are eliminated in urine.
Slovenian: Z urinom se izloči zanemarljiva (1 %) količina BZA.
English: This medicinal product contains sorbitol which may affect the bioavailability of other concomitantly administered medicinal products.
Slovenian: To zdravilo vsebuje sorbitol, ki lahko vpliva na biološko uporabnost drugih sočasno uporabljenih zdravil.
English: CE/BZA can be administered with or without food.
Slovenian: Kombinacijo CE/BZA se lahko daje s hrano ali brez nje.
English: • Increases in liver enzymes (identified in routine liver function testing)
Slovenian: • zvišanje jetrnih encimov (ugotovljeno pri rutinskem testiranju jetrne funkcije);
English: If any of the following conditions are present, have occurred previously, and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised.
Slovenian: Če se pojavi katerokoli od naslednjih bolezenskih stanj oziroma, če se je katerokoli od njih pojavilo že prej in/ali se je med nosečnostjo ali predhodnim hormonskim zdravljenjem poslabšalo, je treba bolnico skrbno nadzirati.
English: If more than one tablet has been forgotten, only the most recent tablet should be taken, the patient should not take double the usual dose to make up for missed tablets.
Slovenian: Če je pozabila vzeti več kot eno tableto, mora vzeti samo zadnjo in ne sme vzeti dvojnega običajnega odmerka, da nadomesti pozabljene tablete.
English: CE/BZA may be taken at any time of day, without regard to meals (see section 5.2).
Slovenian: CE/BZA se lahko jemlje kadarkoli čez dan, ne glede na obroke (glejte poglavje 5.2).
English: Following intravenous administration of a 3 mg dose of BZA alone, the volume of distribution is 14.7 3.9 l/kg.
Slovenian: Po intravenski uporabi 3-mg odmerka samega BZA je volumen porazdelitve 14,73,9 l/kg.
English: Oestrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organs.
Slovenian: Estrogeni se obsežno porazdelijo po telesu, v večjih koncentracijah pa jih je na splošno mogoče najti v ciljnih organih za spolne hormone.
English: BZA is extensively metabolised in women.
Slovenian: BZA se pri ženskah obsežno presnavlja.
English: A meta-analysis from 52 epidemiological studies reported an increased risk of ovarian cancer in women currently using HRT compared to women who have never used HRT (RR 1.43, 95% CI 1.31-1.56).
Slovenian: Pri metaanalizi 52 epidemioloških študij so poročali o povečanem tveganju za raka jajčnikov pri ženskah, ki trenutno uporabljajo HNZ, v primerjavi z ženskami, ki niso nikoli uporabljale HNZ (relativno tveganje 1,43, 95 % IZ 1,31-1,56).
English: • Memory loss (dementia)
Slovenian: • izguba spomina (demenca);
English: If you are having an operation
Slovenian: Če imate načrtovan kirurški poseg
English: Increases in blood pressure
Slovenian: zvišanje krvnega tlaka
English: Like all medicines, this medicine can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi to zdravilo neželene učinke, ki pa se ne pojavijo pri vseh bolnicah.
English: - Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Slovenian: - Preobčutljivost na učinkovino ali katerokoli pomožno snov, navedeno v poglavju 6.1.
English: (thrombosis)'
Slovenian: (tromboza)«.
English: Results of the largest randomised placebo-controlled trial (WHI-study) and largest epidemiological study (MWS) are presented.
Slovenian: Prikazani so rezultati največjega randomiziranega, s placebom nadzorovanega preskušanja (študija WHI) in največje epidemiološke študije (MWS).
English: It should be taken into account that these conditions may recur or be aggravated during treatment with CE/BZA, in particular:
Slovenian: Treba je upoštevati, da se med zdravljenjem s CE/BZA ta bolezenska stanja lahko ponovijo ali poslabšajo, zlasti:
English: In addition, women taking CE/BZA should be advised to move about periodically during travel involving prolonged immobilisation.
Slovenian: Poleg tega je treba ženskam, ki jemljejo CE/BZA, svetovati, da se med potovanjem, pri katerem so dlje časa nepremične, občasno gibljejo.
English: However, if it is almost time to take your next tablet, skip the tablet you missed and only take your next scheduled tablet.
Slovenian: Če pa je skoraj čas za naslednjo tableto, izpustite pozabljeno tableto in vzemite samo naslednjo načrtovano tableto.
English: The European Medicines Agency has waived the obligation to submit the results of studies with CE/BZA in all subsets of the paediatric population in the ‘treatment of oestrogen deficiency symptoms in postmenopausal women' (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od obveze za predložitev rezultatov študij s kombinacijo CE/BZA za vse podskupine pediatrične populacije za »zdravljenje simptomov pomanjkanja estrogena pri ženskah v postmenopavzi« (za informacije o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: In case of overdose it is recommended that the patient be monitored for any signs or symptoms of adverse reactions and appropriate symptomatic treatment be instituted immediately.
Slovenian: V primeru prevelikega odmerjanja je priporočljivo bolnico spremljati glede kakršnihkoli znakov ali simptomov neželenih učinkov in takoj uvesti ustrezno simptomatsko zdravljenje.
English: If you decide to stop taking this medicine before finishing the prescribed course of treatment, you should talk to your doctor first.
Slovenian: Če se odločite, da boste prenehali jemati to zdravilo, preden se konča predpisano zdravljenje, se morate najprej posvetovati z zdravnikom.
English: In a pharmacokinetic study (n=24) BMI appeared to have little impact on systemic exposure to CE and BZA.
Slovenian: V farmakokinetični študiji (n = 24) se je izkazalo, da ima ITM majhen vpliv na sistemsko izpostavljenost CE in BZA.
English: The occurrence of such an event is more likely in the first year of HRT than later (see section 4.8).
Slovenian: Pojav takega dogodka je verjetnejši v prvem letu hormonskega nadomestnega zdravljenja (HNZ) kot pozneje (glejte poglavje 4.8).
English: *study in women with no uterus
Slovenian: * Študija pri ženskah brez maternice
English: Based on available data no dosage adjustment is necessary based on age (see section 5.2).
Slovenian: Na podlagi razpoložljivih podatkov prilagajanje odmerka glede na starost ni potrebno (glejte poglavje 5.2).
English: Oestrogen therapy use does not improve cognitive function.
Slovenian: Zdravljenje z estrogeni ne izboljša kognitivne funkcije.
English: 17β-estradiol is converted reversibly to estrone, and both can be converted to estriol, which is the major urinary metabolite.
Slovenian: 17β-estradiol se reverzibilno pretvori v estron, oba pa se lahko pretvorita v estriol, ki je glavni presnovek v urinu.
English: In vitro and in vivo studies have shown that oestrogens are partially metabolised by cytochrome P450 enzymes, including CYP3A4.
Slovenian: Študije in vitro ter in vivo so pokazale, da se estrogeni delno presnavljajo preko encimov citokroma P450, vključno s CYP3A4.
English: Since you are more likely to get a blood clot in your veins as you get older and if any of the following applies to you, inform your doctor promptly:
Slovenian: Ker je verjetnost, da bo nastal krvni strdek v venah, z naraščanjem starosti večja, in če karkoli izmed navedenega velja za vas, nemudoma obvestite zdravnika:
English: • go for regular breast screening and cervical smear tests, as recommended by your doctor.
Slovenian: • opravite redni preventivni pregled dojk in bris materničnega vratu, kot to priporoča vaš zdravnik;
English: If you are going to have surgery, tell the surgeon you are taking DUAVIVE.
Slovenian: Če imate načrtovan kirurški poseg, povejte kirurgu, da jemljete zdravilo DUAVIVE.
English: Oestrogens circulate in the blood largely bound to SHBG and albumin.
Slovenian: V krvnem obtoku so estrogeni v veliki meri vezani na SHBG in albumin.
English: • Low levels of blood calcium (hypocalcaemia); frequently there will be no symptoms to suggest that your blood calcium is low, but when hypocalcaemia is severe you may feel tired, generally unwell, depressed and become dehydrated.
Slovenian: • nizke ravni kalcija v krvi (hipokalciemija); pogosto ni opaznih simptomov, ki kažejo na pomanjkanje kalcija v krvi, vendar se pri hudi hipokalciemiji lahko počutite utrujeno, na splošno slabo, ste depresivni ali dehidrirate.
English: The results of most epidemiological studies to date relevant to inadvertent foetal exposure to oestrogens indicate no teratogenic or foetotoxic effects.
Slovenian: Rezultati večine do sedaj opravljenih epidemioloških študij v zvezi z nenamernim izpostavljanjem zarodka estrogenom ne kažejo nobenih teratogenih ali fetotoksičnih učinkov.
English: Safety and efficacy have not been evaluated further in women with hepatic insufficiency.
Slovenian: Varnosti in učinkovitosti pri ženskah z jetrno insuficienco niso dodatno ocenjevali.
English: Some other studies, including the WHI trial, suggest that use of combined HRTs may be associated with a similar or slightly smaller risk (see section 4.8).
Slovenian: Nekatere druge študije, vključno s preskušanjem WHI, kažejo, da je uporaba kombiniranih HNZ lahko povezana s podobnim ali rahlo manjšim tveganjem (glejte poglavje 4.8).
English: For more information, see ‘Blood clots in a vein
Slovenian: Za dodatne informacije glejte »Krvni strdki v veni
English: This increase is most likely attributable to age-related changes in hepatic function.
Slovenian: To zvečanje je najverjetneje mogoče pripisati starostnim spremembam v delovanju jeter.
English: The pharmacokinetics of a 20 mg single dose of BZA were evaluated in a study in 26 healthy postmenopausal women.
Slovenian: Farmakokinetiko enkratnega 20 mg odmerka BZA so ocenili v študiji pri 26 zdravih ženskah v postmenopavzi.
English: The number of extra cases of stroke due to use of HRT will increase with age.
Slovenian: Število dodatnih primerov možganske kapi zaradi uporabe HNZ se veča s starostjo.
English: BZA is highly bound (98% - 99%) to plasma proteins in vitro, but does not bind to sex hormone binding globulin (SHBG).
Slovenian: BZA se in vitro v veliki meri (98 %-99 %) veže na beljakovine v plazmi, vendar se ne veže na globulin, ki veže spolne hormone (SHBG).
English: T3 resin uptake is decreased, reflecting the elevated TBG.
Slovenian: Vezava T3 na smolo je zmanjšana, kar odraža zvečanje TBG.
English: What DUAVIVE is and what it is used for
Slovenian: Kaj je zdravilo DUAVIVE in za kaj ga uporabljamo
English: Before initiating or reinstituting treatment with CE/BZA, a complete personal and family medical history should be taken.
Slovenian: Pred začetkom prvega ali ponovnega zdravljenja s CE/BZA je treba raziskati celotno osebno in družinsko anamnezo.
English: Stop taking DUAVIVE and see a doctor immediately if you get any of the following serious side effects:
Slovenian: Prenehajte jemati zdravilo DUAVIVE in nemudoma obiščite zdravnika, če opazite kateregakoli izmed spodaj navedenih resnih neželenih učinkov:
English: Coronary artery disease (CAD)
Slovenian: Koronarna arterijska bolezen (KAB)
English: Women should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e.g., painful swelling of a leg, sudden pain in the chest, dyspnoea).
Slovenian: Ženske je treba opozoriti, naj nemudoma obiščejo svojega zdravnika, če se pojavijo morebitni simptomi trombembolije (npr. boleče otekanje noge, nenadna bolečina v prsnem košu, dispneja).
English: The most commonly reported adverse reaction is abdominal pain, occurring in more than 10% of patients in clinical trials.
Slovenian: Neželeni učinek, o katerem so najpogosteje poročali, je bila bolečina v trebuhu, ki se je med kliničnimi preskušanji pojavila pri več kot 10 % bolnic.
English: The expiry date refers to the last date of that month.
Slovenian: Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Pharmacotherapeutic group: Sex hormones and modulators of the genital system; estrogens, combinations with other drugs; ATC code: G03CC07
Slovenian: Farmakoterapevtska skupina: spolni hormoni in zdravila za uravnavanje delovanja spolovil; estrogeni v kombinaciji z drugimi učinkovinami; oznaka ATC: G03CC07.
English: This can cause symptoms such as hot face, neck and chest ("hot flushes").
Slovenian: To lahko povzroči simptome, kot je občutek vročine v obrazu, vratu in prsih (»vročinski oblivi«).
English: This medicine is for use only by postmenopausal women.
Slovenian: To zdravilo je namenjeno uporabi samo pri ženskah po menopavzi.
English: CE/BZA has not been studied in women with baseline triglyceride levels >300 mg/dL (>3.4 mmol/L).
Slovenian: Kombinacije CE/BZA pri ženskah z izhodiščnimi vrednostmi trigliceridov > 300 mg/dl (> 3,4 mmol/l) niso raziskovali.
English: Talk to your doctor before taking this medicine if you have ever had any of the following problems, as these may return or become worse during treatment with DUAVIVE.
Slovenian: Pred začetkom jemanja tega zdravila se posvetujte z zdravnikom, če ste kadarkoli imeli ali imate katerokoli izmed naštetih bolezni, saj se te med zdravljenjem z zdravilom DUAVIVE lahko ponovijo ali poslabšajo.
English: Women already on chronic anticoagulant treatment require careful consideration of the benefit risk of use of hormone therapy.
Slovenian: Pri ženskah, ki se že kronično zdravijo z antikoagulansi, je treba skrbno pretehtati razmerje koristi in tveganja hormonskega zdravljenja.
English: • Worsening of porphyria, a rare blood disorder which is passed down in families (inherited).
Slovenian: • poslabšanje porfirije, redke bolezni krvi, ki se prenaša v družini (je dedna).
English: • An effect on the way in which your blood sugar (glucose) levels are controlled including increased glucose levels in the blood
Slovenian: • vpliv na način, na katerega telo nadzira ravni sladkorja v krvi (glukozo), vključno z zvišanimi ravnmi glukoze v krvi;
English: Depending on the duration of oestrogen-only use and oestrogen dose, the increase in risk of endometrial cancer in epidemiology studies varied from 5 to 55 extra cases diagnosed in every 1,000 women between the ages of 50 and 65 years.
Slovenian: Glede na trajanje zdravljenja samo z estrogenom in odmerke estrogena je znašalo zvečanje tveganja za raka endometrija v epidemioloških študijah med 5 in 55 dodatnih diagnosticiranih primerov na vsakih 1.000 žensk, starih od 50 do 65 let.
English: Before you start taking this medicine, your doctor will ask you about your own and your family's medical history.
Slovenian: Preden začnete uporabljati to zdravilo, vas bo zdravnik vprašal o vaši osebni in družinski anamnezi (pretekle bolezni in zdravstvena stanja vas in vaših družinskih članov).
English: Breast cancer risk associated with the use of oestrogens alone is represented by several studies.
Slovenian: Tveganje za raka dojke, povezano z uporabo samo estrogena, so predstavili v več študijah.
English: If any of the above conditions appear for the first time while taking this medicine, stop taking it at once and consult your doctor immediately.
Slovenian: Če se katerakoli izmed zgoraj navedenih bolezni prvič pojavi med tem, ko jemljete to zdravilo, ga nemudoma prenehajte jemati in se posvetujte z zdravnikom.
English: In women with no personal history of VTE but with a first-degree relative with a history of thrombosis at young age, screening may be offered after careful counselling regarding its limitations (only a proportion of thrombophilic defects are identified by screening).
Slovenian: Ženskam, ki nimajo VTE v osebni anamnezi, vendar imajo sorodnika v prvem kolenu z anamnezo tromboze v mladosti, se lahko predlaga presejalni pregled po temeljitem svetovanju o omejitvah takšnega testiranja (pri presejalnih pregledih se odkrije le del trombofiličnih okvar).
English: This medicine contains 0.0088 mg sorbitol in each tablet.
Slovenian: To zdravilo vsebuje 0,0088 mg sorbitola na tableto.
English: In postmenopausal women, a significant proportion of the circulating oestrogens exists as sulfate conjugates, especially estrone sulfate, which serves as a circulating reservoir for the formation of more active oestrogens.
Slovenian: Pri ženskah v postmenopavzi velik delež estrogenov v obtoku obstaja v obliki sulfatnih konjugatov, zlasti estronsulfata, ki deluje kot skladišče za tvorbo aktivnejših estrogenov.
English: For initiation and continuation of treatment of postmenopausal symptoms, the lowest effective dose for the shortest duration should be used (see section 4.4).
Slovenian: Za začetek in nadaljevanje zdravljenja simptomov postmenopavze je treba uporabiti najmanjši učinkoviti odmerek, trajanje uporabe pa mora biti čim krajše (glejte poglavje 4.4).
English: Pharmacokinetic studies for CE/BZA were conducted in healthy postmenopausal women who were naturally postmenopausal or who had undergone bilateral oophorectomy.
Slovenian: Farmakokinetične študije kombinacije CE/BZA so izvedli pri zdravih ženskah v postmenopavzi, ki so bile naravno v postmenopavzi ali pa so imele bilateralno ooforektomijo.