FrancophonIA/ELRC3.0 huggingface dataset:
English: All were treated with a single infusion of Coagadex; mean and median doses 31.7 IU/kg (range 24.6 to 38.8 IU/kg) and all recorded efficacy ratings were categorized as excellent.
Croatian: Svi su liječeni jednom infuzijom lijeka Coagadex; srednja vrijednost i medijan doza iznosili su 31,7 IU/kg (raspon od 24,6 do 38,8 IU/kg) a sve zabilježene ocjene djelotvornosti bile su kategorizirane kao odlične.
English: It is recommended that post-infusion plasma factor X levels are measured for each patient before and after surgery, to ensure that haemostatic levels are obtained and maintained.
Croatian: Preporučuje se da se razine faktora X u plazmi nakon infuzije mjere za svakog bolesnika prije i nakon operativnog zahvata, kako bi se osiguralo ostvarivanje i održavanje hemostatskih razina.
English: Coagadex is likely to be counteracted by factor Xa inhibitors, direct or indirect.
Croatian: Učinak Coagadexa će vjerojatno biti poništen inhibitorima faktora Xa, direktnim ili indirektnim.
English: Do not use this medicine if you notice small bits in the dissolved product.
Croatian: Nemojte primijeniti ovaj lijek ako primijetite čestice u otopljenom lijeku.
English: In adults and adolescents at least 12 years of age, the expected in vivo peak increase in factor X level expressed as IU/dL (or % of normal) can be estimated using the following formulae:
Croatian: U odraslih i adolescenata u dobi od najmanje 12 godina, očekivani vršni porast razine faktora X in vivo izražen kao IU/dl (ili % normalne vrijednosti) može se procijeniti primjenom sljedeće formule:
English: Some patients may achieve desired FX trough levels on once weekly prophylactic therapy (see section 5.1).
Croatian: U nekih se bolesnika željena koncentracija faktora X može postići profilaktičkom terapijom jednom tjedno (vidjeti dio 5.1).
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: If expected factor X activity levels are not attained, or if bleeding is not controlled with an expected dose, perform an assay that measures factor X inhibitor concentration.
Croatian: Ako se ne postignu očekivane razine aktivnosti faktora X ili ako krvarenje nije kontrolirano očekivanom dozom, provedite test koji mjeri koncentraciju inhibitora faktora X.
English: The efficacy of Coagadex in treating bleeding episodes was assessed by the subject and/or investigator for each new bleeding episode, using a pre-determined bleed-specific ordinal rating scale of excellent, good, poor and unassessable.
Croatian: Djelotvornost lijeka Coagadex u liječenju epizoda krvarenja procijenjena je od strane ispitanika i/ili ispitivača za svaku novu epizodu krvarenja prethodno zadanom ljestvicom ocjenjivanja krvarenja sa stavkama odlično, dobro, slabo i nemoguće procijeniti.
English: No investigations on genotoxicity, carcinogenicity and reproductive or developmental toxitcity have been conducted since human plasma coagulation factor X (as contained in Coagadex) is an endogenous protein.
Croatian: Ispitivanja genotoksičnosti, kancerogenosti kao ni reproduktivne ili razvojne toksičnosti nisu provedena jer je koagulacijski faktor X iz ljudske plazme (sadržan u lijeku Coagadex) endogeni protein.
English: Due to inter-and intra-patient variability, it is recommended that trough blood levels of Factor X should be monitored at intervals, especially in the first weeks of therapy or after dosage changes.
Croatian: Zbog varijabilnosti između bolesnika te u svakog pojedinog bolesnika, preporučuje se u intervalima pratiti najnižu koncentraciju faktora X u krvi, osobito u prvim tjednima terapije ili nakon promjene doze.
English: This medicinal product contains up to 0.4 mmol/mL (9.2 mg/mL) of sodium.
Croatian: Ovaj lijek sadrži do 0,4 mmol/ml (9,2 mg/ml) natrija.
English: Your doctor will recommend an appropriate dose for you.
Croatian: Odgovarajuću dozu preporučit će Vam liječnik.
English: A transfer device called Mix2Vial is also provided.
Croatian: Također je priložena naprava za prijenos nazvana Mix2Vial.
English: What Coagadex looks like and contents of the pack
Croatian: Kako Coagadex izgleda i sadržaj pakiranja
English: - if you are allergic to human coagulation factor X or any of the other ingredients of this medicine
Croatian: - ako ste alergični na ljudski koagulacijski faktor X ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: The solution should be colourless, clear or slightly opalescent when administered.
Croatian: Otopina mora biti bezbojna, bistra ili blago opalescentna kada se primjenjuje.
English: Systemic exposure to FX:C at the Repeat PK visit (at least 6 months later) was equivalent to that at baseline, since repeat/baseline ratios for all PK parameters were within the range of 90% to 110%.
Croatian: Sistemska izloženost aktivnosti faktora X kod ponovljenog posjeta za FK (najmanje 6 mjeseci kasnije) bila je ekvivalentna onoj početnoj jer su omjeri ponovljenog/početnog za sve FK parametre bili unutar raspona od 90% do 110%.
English: After reconstitution, from a microbiological point of view, the product should be used immediately.
Croatian: S mikrobiološkog gledišta, lijek treba upotrijebiti odmah nakon rekonstitucije.
English: Each vial contains nominally 250 IU or 500 IU human coagulation factor X.
Croatian: Svaka bočica sadrži nominalno 250 IU ili 500 IU ljudskog koagulacijskog faktora X.
English: The dose and duration of the treatment depend on the severity of the factor X deficiency (i.e. the patient's baseline factor X level), on the location and extent of the bleeding and on the patient's clinical condition.
Croatian: Doziranje Doza i trajanje liječenja ovise o težini nedostatka faktora X (tj. bolesnikovoj početnoj vrijednosti razine faktora X), o mjestu i opsegu krvarenja te o kliničkom stanju bolesnika.
English: Your doctor may recommend that you consider vaccination against hepatitis A and B if you regularly or repeatedly receive human plasma-derived factor X products.
Croatian: Vaš liječnik može Vam preporučiti da razmotrite cijepljenje protiv hepatitisa A i B ako redovito ili opetovano primate lijekove s faktorom X dobivenim iz ljudske plazme.
English: Coagadex is a concentrate of human coagulation factor X, a protein that is needed for blood to clot.
Croatian: Coagadex je koncentrat ljudskog koagulacijskog faktora X, protein koji je potreban za zgrušavanje krvi.
English: Certain anticoagulants including those blocking a blood clotting factor (factor Xa) should not be used in patients with factor X deficiency receiving Coagadex due to a risk of blood clots.
Croatian: Neki antikoagulansi uključujući one koji blokiraju faktor zgrušavanja krvi (faktor Xa) ne smiju se koristiti kod bolesnika s nedostatkom faktora X koji primaju Coagadex zbog opasnosti od stvaranja krvnih ugrušaka.
English: There are limited data on the use of Coagadex for long periods of prophylaxis in adults.
Croatian: Ograničeni su podaci o primjeni lijeka Coagadex tijekom duljih razdoblja profilakse u odraslih.
English: Gently swirl the vial to make sure the powder is thoroughly mixed.
Croatian: Nježno provrtite bočicu kako biste bili sigurni da je prašak u potpunosti izmiješan.
English: If you know you have used too much, tell the doctor, pharmacist or nurse as soon as possible.
Croatian: Ako znate da ste primijenili previše lijeka, obratite se liječniku, ljekarniku ili medicinskoj sestri što je prije moguće.
English: The adverse reactions that occurred in the highest frequency were infusion site erythema, infusion site pain, fatigue, and back pain.
Croatian: Nuspojave koje su se najčešće pojavljivale bile su eritem na mjestu infuzije, bol na mjestu infuzije, umor i bol u leđima.
English: Coagadex replaces the missing factor X and allows their blood to clot normally.
Croatian: Coagadex zamjenjuje nedostajući faktor X i omogućuje normalno zgrušavanje krvi.
English: The expected in vivo peak increase in factor X level expressed as IU/dL (or % of normal) can be estimated using the following formulae:
Croatian: Očekivani vršni porast razine faktora X in vivo izražen kao IU/dl (ili % normalne vrijednosti) može se procijeniti primjenom sljedeće formule:
English: Human coagulation factor X is largely retained within the vascular compartment: mean apparent volume of distribution (Vss) was 56.3 (24.0) mL/kg.
Croatian: Ljudski koagulacijski faktor X velikim dijelom se zadržava u krvožilnom odjeljku: srednji prividni volumen distribucije (Vss) bio je 56,3 (24,0) ml/kg.
English: It is used to treat and prevent bleeding in patients with hereditary factor X deficiency, including during surgery.
Croatian: Koristi se za liječenje i sprečavanje krvarenja u bolesnika s nasljednim nedostatkom faktora X, uključujući tijekom operativnog zahvata.
English: Other medicines and Coagadex
Croatian: Drugi lijekovi i Coagadex
English: If you think you may be using too much, stop the injection and tell the doctor, pharmacist or nurse.
Croatian: Ako mislite da možda primjenjujete previše lijeka, prekinite injiciranje i obratite se liječniku, ljekarniku ili medicinskoj sestri.
English: The factor X in Coagadex is extracted from human plasma (the liquid part of blood).
Croatian: Faktor X u lijeku Coagadex se dobiva iz ljudske plazme (tekućeg dijela krvi).
English: It is strongly recommended that every time that Coagadex is administered to a patient, the name and batch number of the product are recorded in order to maintain a link between the patient and the batch of the product.
Croatian: Izrazito se preporučuje da se svaki put kada se Coagadex primjenjuje bolesniku, zabilježe naziv i broj serije lijeka kako bi se održala veza između bolesnika i serije lijeka.
English: A total of 537 (mean 59.7 per subject) prophylactic infusions were administered.
Croatian: Primijenjeno je ukupno 537 (srednja vrijednost 59,7 po ispitaniku)
English: Coagadex contains up to 0.4 mmol/mL (9.2 mg/mL) of sodium.
Croatian: Coagadex sadrži do 0,4 mmol/ml (9,2 mg/ml) natrija.
English: Vaccination against hepatitis A and B in patients who regularly or repeatedly receive human plasma-derived Factor X products may be warranted.
Croatian: Cijepljenje protiv hepatitisa A i B u bolesnika koji redovito ili opetovano primaju lijekove s faktorom X dobivenim iz ljudske plazme može biti opravdano.
English: • Draw air into the syringe by pulling the plunger to the required volume of water added.
Croatian: • Uvucite zrak u štrcaljku povlačeći klip do potrebnog volumena dodane vode.
English: There were no adverse drug reactions in this study in children less than 12 years of age.
Croatian: U ovom ispitivanju nije bilo nuspojava lijeka u djece mlađe od 12 godina.
English: The desired factor X rise is the difference between the patient's plasma factor X level and the desired level, and based on the observed recovery of 2 IU/dL per IU/kg.
Croatian: Željeni porast faktora X je razlika između razine faktora X u plazmi bolesnika i željene razine, a temelji se na opaženom povratu od 2 IU/dl po IU/kg.
English: The formation of neutralising antibodies (inhibitors) to factor X is a possible complication in the management of individuals with factor X deficiency.
Croatian: Stvaranje neutralizirajućih antitijela (inhibitora) za faktor X moguća je komplikacija u liječenju osoba s nedostatkom faktora X.
English: Draw air into the syringe by pulling the plunger to the volume of water added.
Croatian: Uvucite zrak u štrcaljku povlačeći klip do volumena dodane vode.
English: For home therapy, the patient should be given appropriate training and reviewed at intervals.
Croatian: Za liječenje kod kuće, bolesnika treba odgovarajuće obučiti te ga redovito kontrolirati.
English: Pharmacokinetic (PK) parameters were calculated from plasma factor X:C (one-stage clotting assay) activity measurements after subtraction of the pre-dose value.
Croatian: Farmakokinetički (FK) parametri izračunati su iz mjerenja aktivnosti faktora X u plazmi (jednofazni test zgrušavanja) nakon oduzimanja vrijednosti prije doziranja.
English: Before: The dose of Coagadex used should be sufficient to raise your blood factor X level to between 70 and 90 units/dL.
Croatian: Prije: Primijenjena doza lijeka Coagadex treba biti dovoljna da podigne Vašu razinu faktora X u krvi na vrijednost između 70 i 90 jedinica/dl.
English: Some patients with a shortage of factor X may develop inhibitors (antibodies) to factor X during treatment.
Croatian: Neki bolesnici s nedostatkom faktora X tijekom liječenja mogu razviti inhibitore (protutijela) na faktor X.
English: Hypersensitivity reactions, allergic reactions, and anaphylaxis have not been reported in Coagadex clinical trials.
Croatian: Reakcije preosjetljivosti, alergijske reakcije i anafilaksija nisu zabilježeni u kliničkim ispitivanjima lijeka Coagadex.
English: • Gently swirl the vial to make sure the powder is thoroughly mixed.
Croatian: • Nježno provrtite bočicu kako biste bili sigurni da je prašak u potpunosti izmiješan.
English: Patients with factor X deficiency do not have sufficient factor X for their blood to clot properly, leading to excessive bleeding.
Croatian: Bolesnici s nedostatkom faktora X nemaju dovoljne količine faktora X za normalno zgrušavanje krvi što uzrokuje prekomjerno krvarenje.
English: Step 4: The solvent will be pulled into the powder vial by the vacuum contained within it.
Croatian: 4. korak: Otapalo će se uvući u bočicu s praškom pomoću vakuuma koji se nalazi u njoj.
English: Coagadex is derived from human plasma and used as a replacement for the naturally existing coagulation factor X in patients with hereditary factor X deficiency.
Croatian: Coagadex se dobiva iz ljudske plazme i koristi kao zamjena za prirodno postojeći koagulacijski faktor X u bolesnika s nasljednim nedostatkom faktora X.
English: The mean (CV%) half-life of human coagulation factor X was 30.3 (22.8) hr and clearance was 1.35 (21.7) mL/kg/hr.
Croatian: Srednji (CV%) poluvijek ljudskog koagulacijskog faktora X bio je 30,3 (22,8) h, a klirens je iznosio 1,35 (21,7) ml/kg/h.
English: A peak factor X level of 90% of normal is required in a 70 kg patient.
Croatian: Vršna razina faktora X od 90 % normalne vrijednosti potrebna je u bolesnika tjelesne težine od
English: The mean (CV%) for incremental recovery was 2.08 (18.1).
Croatian: Srednja vrijednost (CV%) za prirast po jedinici doze bila je 2,08 (18,1).
English: The mean (CV%) maximum plasma concentration (Cmax) was 0.504 (17.2) IU/mL.
Croatian: Srednja vrijednost (CV%) najviše koncentracije u plazmi (Cmax) bila je 0,504 (17,2) IU/ml.
English: 25 IU/kg twice weekly is the proposed starting dose for prophylaxis in patients >12 years of age with dose levels and dosing intervals to be adjusted as clinically indicated.
Croatian: >12 godina kao početna doza predlaže se 25 IU/kg dva puta tjedno, s tim da razine doze i intervale doziranja treba prilagoditi kako je klinički indicirano.
English: Disconnect the filled syringe from the device.
Croatian: Odvojite napunjenu štrcaljku od naprave.
English: Repeat this step with the solvent vial.
Croatian: Ponovite ovaj korak s bočicom otapala.
English: What you need to know before you use Coagadex 3.
Croatian: Što morate znati prije nego počnete primjenjivati Coagadex
English: This should be taken into consideration by patients on a controlled sodium diet.
Croatian: To treba uzeti u obzir za bolesnike na dijeti s kontroliranim unosom natrija.
English: Coagadex should not be used as an antidote to the effects of direct oral anti-coagulants (DOACs) in patients who do not have factor X deficiency.
Croatian: Coagadex se ne smije koristiti kao antidot za učinke direktnih oralnih antikoagulansa kod bolesnika koji nemaju nedostatak faktora X.
English: Routine prophylaxis was started with unit doses of 40-50 IU/kg and during the first 6 weeks trough levels of Factor X were measured to adjust the dosage regimen to maintain a trough level of at least 5 IU/dL.
Croatian: Rutinska profilaksa započeta je jediničnim dozama od 40-50 IU/kg, a tijekom prvih 6 tjedana mjerene su najniže koncentracije faktora X kako bi se režim doziranja prilagodio tako da se održi najmanja koncentracija od barem 5 IU/dL.
English: Post-surgery: dose as necessary to maintain plasma factor X levels at a minimum of 50 IU/dL until the subject is no longer at risk of bleeding due to surgery.
Croatian: Nakon operativnog zahvata: dozirati prema potrebi za održavanje razina faktora X u plazmi od najmanje 50 IU/dl, sve dok u osobe više ne postoji rizik od krvarenja uslijed operativnog zahvata.
English: When medicines are made from human blood or plasma, certain measures are put in place to prevent infections being passed on to recipients.
Croatian: Kada se lijekovi dobivaju iz ljudske krvi ili plazme, poduzimaju se određene mjere opreza kako bi se spriječilo prenošenje infekcija na primatelje.
English: - careful selection of blood and plasma donors to make sure those at risk of carrying infections are excluded, - the testing of each donation and pools of plasma for signs of virus/infections, - the inclusion of steps in the processing of the blood or plasma that can inactivate or remove viruses.
Croatian: - pažljiv odabir darivatelja krvi i plazme kako bi bili sigurni da su isključeni oni koji nose rizik prenošenja infekcija, - testiranje svake donacije i prikupljene plazme na znakove virusa/infekcija,
English: Hypersensitivity or allergic reactions (which may include angioedema, burning and stinging at the infusion site, chills, flushing, generalised urticaria, headache, hives, hypotension, lethargy, nausea, restlessness, tachycardia, tightness of the chest, tingling, vomiting, wheezing) have been observed rarely with treatment of other haemophilias and may in some cases have progressed to severe anaphylaxis (including shock).
Croatian: Reakcije preosjetljivosti ili alergijske reakcije (koje mogu uključivati angioedem, žarenje i peckanje na mjestu infuzije, zimicu, navale crvenila, generaliziranu urtikariju, glavobolju, koprivnjaču, hipotenziju, letargiju, mučninu, nemir, tahikardiju, stezanje u prsištu, trnce, povraćanje, piskanje pri disanju) rijetko su zabilježene u liječenju drugih hemofilija i u nekim se slučajevima mogu razviti u tešku anafilaksiju (uključujući šok).
English: However, chemical and physical in-use stability has been demonstrated for 1 hour at room temperature (up to 25°C +/-2°C).
Croatian: Međutim, utvrđena je kemijska i fizikalna stabilnost u primjeni tijekom 1 sata na sobnoj temperaturi
English: Dissolving your medicines before use
Croatian: Otapanje lijeka prije primjene
English: Despite these measures, when medicines prepared from human blood or plasma are administered, the possibility of passing on an infection cannot be totally excluded.
Croatian: Usprkos tim mjerama, kada se primjenjuju lijekovi pripremljeni od ljudske krvi ili plazme, ne može se u potpunosti isključiti mogućnost prijenosa infekcije.
English: Adjust dosage regimen to clinical response and trough levels of Factor X of at least 5 IU/dL.
Croatian: Režim doziranja treba prilagoditi prema kliničkom odgovoru i najnižim koncentracijama faktora X od najmanje 5 IU/dl.
English: If you get any of these contact your doctor.
Croatian: Ako primijetite bilo koji od ovih simptoma, obratite se svom liječniku.
English: The other two subjects used doses up to 30 IU/kg and 33 IU/kg.
Croatian: Drugo dvoje ispitanika primalo je doze do 30 IU/kg i 33 IU/kg.
English: There is a potential for thromboembolism with overdose.
Croatian: Pri predoziranju je moguća pojava tromboembolije.
English: It is strongly recommended that every time you receive a dose of Coagadex, the name and batch number of the product are recorded in order to maintain a record of the batches used.
Croatian: Izrazito se preporučuje da se svaki put kada primite dozu lijeka Coagadex zapiše naziv i broj serije lijeka kako bi se vodila evidencija o primijenjenim serijama.
English: These antithrombotic agents should not be used in patients with factor X deficiency.
Croatian: Ti antitrombotički lijekovi ne smiju se primjenjivati kod bolesnika s nedostatkom faktora X.
English: The safety and efficacy of Coagadex for perioperative management was evaluated in five subjects aged 14 to 59 years with mild (n=2), moderate (n=1), and severe (n=2) disease, who underwent a total of seven surgical procedures.
Croatian: Kirurška hemostaza Sigurnost i djelotvornost lijeka Coagadex za perioperativno zbrinjavanje procijenjene su kod petero ispitanika u dobi od 14 do 59 godina s blagom (n=2), umjerenom (n=1) i teškom (n=2) bolešću koji su prošli ukupno sedam kirurških zahvata.
English: Required dose (IU) = body weight (kg) x desired factor X rise (IU/dL) x 0.5
Croatian: Potrebna doza (IU) = tjelesna težina (kg) x željeni porast faktora X (IU/dl) x 0,5
English: Adults and adolescents aged 12 years or more for treatment of bleeding episodes: 25 IU/kg Coagadex should be injected when the first sign of bleeding occurs or just before the expected onset of menstrual bleeding.
Croatian: Za liječenje epizoda krvarenja u odraslih i adolescenata u dobi od 12 ili više godina: potrebno je injicirati 25 IU/kg lijeka Coagadex kada se pojavi prvi znak krvarenja ili neposredno prije očekivanog početka menstrualnog krvarenja.
English: Example: to raise plasma factor X level from 15 IU/dL to 90 IU/dL in a 70 kg patient, the appropriate dose is:
Croatian: Primjer: kako bi podigli razinu faktora X u plazmi s 15 IU/dl na 90 IU/dl u bolesnika od 70 kg,
English: Transfer Device (Mix2Vial).
Croatian: 1 naprava za prijenos (Mix2Vial).
English: • pain or redness at site of injection
Croatian: • bol ili crvenilo na mjestu injekcije • umor
English: 500 IU human coagulation factor X, approximately 100 IU/mL
Croatian: 500 IU ljudskog koagulacijskog faktora X, približno 100 IU/ml
English: Remove the plastic outer packaging from the transfer device and discard it, taking care not to touch the exposed end of the device.
Croatian: Uklonite plastično vanjsko pakiranje s naprave za prijenos i bacite ga, pazeći da ne dodirujete izloženi dio naprave.
English: Routine prophylaxis was used by two subjects.
Croatian: Dvoje ispitanika primalo je rutinsku profilaksu.
English: • The solvent will be pulled into the powder vial by the vacuum contained within it.
Croatian: • Otapalo će se uvući u bočicu s praškom pomoću vakuuma koji se nalazi u njoj.
English: The product should only be reconstituted using the Mix2Vial that is provided in the pack.
Croatian: Lijek se smije rekonstituirati samo pomoću naprave Mix2Vial koja je priložena u pakiranju.
English: Transmissible Agents
Croatian: Prenosivi uzročnici
English: 250 IU human coagulation factor X, approximately 100 IU/mL
Croatian: 250 IU ljudskog koagulacijskog faktora X, približno 100 IU/ml
English: • Remove the plastic outer packaging from the transfer device and discard it, taking care not to touch the exposed end of the device.
Croatian: • Uklonite plastično vanjsko pakiranje s naprave za prijenos i bacite ga, pazeći da ne dodirujete izloženi dio naprave.
English: Coagadex is indicated for the treatment and prophylaxis of bleeding episodes and for perioperative management in patients with hereditary factor X deficiency.
Croatian: Coagadex je indiciran za liječenje i profilaksu epizoda krvarenja i za perioperativno zbrinjavanje bolesnika s nasljednim nedostatkom faktora X.
English: Therefore, Coagadex should be used during breast-feeding only if clearly indicated.
Croatian: Stoga se Coagadex smije primjenjivati tijekom dojenja samo ako je jasno indicirano.
English: For the subgroup aged 6-11 years (n=5), the geometric mean IR30min was 1.91 (range 1.6 -2.2) IU/mL per IU/kg and for the youngest subgroup, 0-5 years (n=4) was 1.53range 1.3-1.8) IU/mL per IU/kg.
Croatian: U dobnoj skupini od 6 do 11 godina (n=5), geometrijska sredina IR30min iznosila je 1,91 (raspon 1,6-2,2) IU/ml po IU/kg, a u podskupini najmlađe djece, od 0 do 5 godina (n=4) iznosila je 1,53 (raspon 1,3-1,8) IU/ml po IU/kg.
English: Routine prophylaxis of bleeding episodes
Croatian: Rutinska profilaksa epizoda krvarenja
English: Keep container in the outer carton in order to protect it from light.
Croatian: Spremnik čuvati u vanjskom pakiranju radi zaštite od svjetlosti.