FrancophonIA/ELRC3.0 huggingface dataset:
English: • tacrolimus (a medicine used to control your body's immune response after a transplant)
Danish: • tacrolimus (et lægemiddel, der anvendes til at kontrollere din krops immunrespons efter en transplantation)
English: Angiotensin Converting Enzyme Inhibitors lisinopril
Danish: Angiotensinkonverterende enzymhæmmere lisinopril
English: Doravirine does not inhibit the human cellular DNA polymerases α, ß, and mitochondrial DNA polymerase γ.
Danish: Doravirin hæmmer ikke de humane cellulære DNA-polymeraser α, ß og mitokondrie-DNA-polymerase γ.
English: < 200 cells/mm
Danish: < 200 celler/mm
English: This adverse reaction may occur as a consequence of proximal renal tubulopathy.
Danish: Denne bivirkning kan forekomme som en konsekvens af proksimal renal tubulopati.
English: HIV-1 isolates with the K65R substitution also showed reduced susceptibility to emtricitabine and lamivudine.
Danish: Hiv-1-isolater med K65R-substitutionen viste også nedsat følsomhed over for emtricitabin og lamivudin.
English: Lamivudine and tenofovir disoproxil are primarily excreted by the kidney.
Danish: Lamivudin og tenofovirdisoproxil udskilles primært via nyrerne.
English: • sirolimus (a medicine used to control your body's immune response after a transplant)
Danish: • sirolimus (et lægemiddel, der anvendes til at kontrollere din krops immunrespons efter en transplantation)
English: In clinical trials in HIV-1 infected adults, tenofovir disoproxil was associated with slightly greater decreases in bone mineral density (BMD) and increases in biochemical markers of bone metabolism, suggesting increased bone turnover relative to comparators.
Danish: I kliniske studier med hiv-1-inficerede voksne var tenofovirdisoproxil forbundet med lidt større reduktioner i knoglemineraltætheden (BMD) og stigninger i niveauet af biokemiske markører for knoglemetabolisering, hvilket tyder på øget knogleomsætning i forhold til komparatorerne.
English: The pharmacokinetics of tenofovir in non-haemodialysis adult subjects with CrCl < 10 mL/min and in subjects with end-stage renal disease managed by peritoneal or other forms of dialysis have not been studied.
Danish: Tenofovirs farmakokinetik hos voksne forsøgspersoner, der ikke er i hæmodialysebehandling og har en CrCl på < 10 ml/min, og hos forsøgspersoner med terminal nyresygdom (ESRD), der behandles med peritonealdialyse eller andre former for dialyse, er ikke undersøgt.
English: The antiviral activity of tenofovir against laboratory and clinical isolates of HIV-1 was assessed in T lymphoblastoid cell lines, primary monocyte/macrophage cells and peripheral blood lymphocytes.
Danish: Tenofovirs antivirale aktivitet mod laboratorie- og kliniske isolater af hiv-1 blev vurderet i T-lymfoblastcellelinjer, primære monocyt-/makrofagceller og lymfocytter fra perifert blod.
English: Expected:  canagliflozin  liraglutide  sitagliptin
Danish: Forventet:  canagliflozin  liraglutid  sitagliptin
English: Expected:  buprenorphine  naloxone
Danish: Forventet:  buprenorphin  naloxon
English: A breakpoint for a reduction in susceptibility, yielded by various NNRTI substitutions, that is associated with a reduction in clinical efficacy has not been established.
Danish: Der er ikke klarlagt et breakpoint for reduktion i følsomhed forårsaget af forskellige NNRTI-substitutioner, der er forbundet med reduktion i klinisk virkning.
English: Lamivudine may inhibit cellular DNA replication (see section 5.3).
Danish: Lamivudin kan hæmme replikation af cellulær DNA (se pkt.
English: At baseline, the median age of subjects was 31 years (range 18-70 years), 85 % were male, 52 % were non-white, 3 % had hepatitis B or C co-infection, 14 % had a history of AIDS, 21 % had HIV-1 RNA > 100,000 copies per mL, and 12 % had CD4
Danish: Ved baseline var forsøgspersonernes medianalder 31 år (interval 18-70 år), 85% var mænd, 52% var ikke kaukasiere, 3% var samtidigt inficeret med hepatitis B- eller C-virus, 14% havde aids i anamnesen, 21% havde hiv-1-RNA > 100.000 kopier pr. ml, og 12% havde et CD4
English: Respiratory, thoracic and mediastinal disorders Common cough*, nasal symptoms*
Danish: Luftveje, thorax og mediastinum Almindelig hoste*, nasale symptomer*
English: None of the 24 subjects (11 in the immediate switch group, 13 in the delayed switch group) with baseline NNRTI mutations (RT K103N, G190A, or Y181C) experienced virologic failure through Week 48, or at time of discontinuation.
Danish: Ingen af de 24 forsøgspersoner (11 i den gruppe der skiftede øjeblikkeligt, 13 i den gruppe der skiftede sent) med NNRTI-mutationerne (RT K103N, G190A eller Y181C) ved baseline oplevede virologisk svigt til og med uge 48 eller på tidspunktet for seponering af behandlingen.
English: At the highest dosage levels, minor effects on indicators of liver and kidney function were seen together with occasional reductions in liver weight.
Danish: Ved de højeste doser sås mindre påvirkning af indikatorer for lever- og nyrefunktion samt af og til en reduktion i levervægt.
English: • decreased number of white blood cells in your blood (neutropenia)
Danish: • nedsat antal hvide blodlegemer i blodet (neutropeni)
English: Refill your prescription or talk to your doctor before your Delstrigo is all gone.
Danish: Forny din recept, eller kontakt lægen, inden du løber tør.
English: Severe acute exacerbations of hepatitis B (e.g., liver decompensated and liver failure) have been reported in patients who are co-infected with HIV-1 and HBV, and have discontinued lamivudine or tenofovir disoproxil, two of the components of Delstrigo.
Danish: Svære akutte eksacerbationer af hepatitis B (f.eks. dekompenseret lever og leversvigt) er rapporteret hos patienter, som er co-inficerede med hiv-1 og hbv og har fået seponeret lamivudin eller tenofovirdisoproxil, der er to af komponenterne i Delstrigo.
English: + T cell count greater than 200 cells per mm
Danish: + T-celletal, som var større end 200 celler pr. mm
English: What Delstrigo looks like and contents of the pack Delstrigo is available as a yellow, oval-shaped, film-coated tablet, and is debossed with the corporate logo and 776 on one side and plain on the other side.
Danish: Delstrigo fås som en gul, oval, filmovertrukken tablet med virksomhedslogo og 776 præget på den ene side og uden prægning på den anden side.
English: In some patients with advanced liver disease or cirrhosis, stopping treatment is not recommended as this may lead to worsening of your hepatitis, which may be life-threatening.
Danish: Det frarådes at stoppe behandlingen hos nogle patienter med fremskreden leversygdom eller levercirrose, da det kan føre til forværring af deres hepatitis, hvilket kan være livstruende.
English: • decreased number of red blood cells in your blood (anaemia)
Danish: • nedsat antal røde blodlegemer i blodet (anæmi)
English: Delstrigo should be discontinued if estimated CrCl declines below 50 mL per minute as dose interval adjustment required for lamivudine and tenofovir disoproxil cannot be achieved with the fixed dose combination tablet (see section 4.2).
Danish: Delstrigo skal seponeres, hvis den estimerede CrCl falder til under 50 ml pr. minut, da den påkrævede trinvise dosisjustering for lamivudin og tenofovirdisoproxil ikke er mulig med fastdosiskombinationstabletten (se pkt.
English: Delstrigo tablets contains lactose
Danish: Delstrigo indeholder lactose
English: • constipation, stomach discomfort, swollen or bloated stomach (abdominal distention),
Danish: • forstoppelse, mavegener, hævet eller oppustet mave (abdominal distention),
English: Lamivudine was mutagenic in an L5178Y mouse lymphoma assay and clastogenic in a cytogenetic assay using cultured human lymphocytes.
Danish: Lamivudin var mutagent i en L5178Y-muselymfom-analyse og klastogent i en cytogenetisk analyse, hvor der blev brugt dyrkede lymfocytter fra mennesker.
English: Ritonavir- or Cobicistat- boosted PI
Danish: Ritonavir- eller cobicistat-boostet PI
English: Based on the lamivudine data, Delstrigo is not recommended for patients with CrCl of < 50 mL/min.
Danish: På baggrund af data om lamivudin frarådes Delstrigo til patienter med en CrCl på < 50 ml/min.
English: Cases of osteomalacia associated with proximal renal tubulopathy, manifested as bone pain or pain in extremities and which may contribute to fractures, have been reported in association with the use of tenofovir disoproxil .
Danish: Tilfælde af osteomalaci associeret med proksimal renal tubulopati, der manifesterede sig som knoglesmerter eller ekstremitetssmerter, og som kan medvirke til frakturer, er rapporteret i forbindelse med anvendelse af tenofovirdisoproxil.
English: Doravirine is primarily metabolised by CYP3A, and medicinal products that induce or inhibit CYP3A are expected to affect the clearance of doravirine (see section 5.2).
Danish: Doravirin metaboliseres primært via CYP3A, og lægemidler, der inducerer eller hæmmer CYP3A, forventes at påvirke doravirins clearance (se pkt.
English: • sofosbuvir/velpatasvir (medicines used to treat hepatitis C infection)
Danish: • sofosbuvir/velpatasvir (lægemidler til behandling af hepatitis C-infektion)
English: Very rare: may affect up to 1 in 10,000 people
Danish: Meget sjælden: kan forekomme hos op til 1 ud af 10.000 personer
English: Due to the tenofovir disoproxil component of doravirine/lamivudine/tenofovir disoproxil, use of the product should be avoided with concurrent or recent use of nephrotoxic medicinal products.
Danish: På grund af tenofovirdisoproxil-komponenten i doravirin/lamivudin/tenofovirdisoproxil skal det undgås at anvende lægemidlet sammen med eller ved nylig anvendelse af nefrotoksiske lægemidler.
English: Delstrigo 100 mg/300 mg/245 mg film-coated tablets.
Danish: Delstrigo 100 mg/300 mg/245 mg filmovertrukne tabletter.
English: Tenofovir displayed antiviral activity in cell culture against HIV-1 clades A, B, C, D, E, F, G, and O (EC50 values ranged from 0.5-2.2 microM).
Danish: I cellekultur udviste tenofovir antiviral aktivitetmod hiv-1 clade A, B, C, D, E, F, G og O (EC50-værdierne lå i intervallet 0,5-2,2 µM).
English: Other medicines and Delstrigo
Danish: Brug af anden medicin sammen med Delstrigo
English: • increased levels of creatinine in your blood
Danish: • forhøjet indhold af kreatinin i blodet
English: Long-term carcinogenicity studies with lamivudine in mice and rats showed no evidence of carcinogenic potential at exposures up to 12 times (mice) and 57 times (rats) the human exposures at the RHD.
Danish: Langtidskarcinogenicitetsstudier med lamivudin hos mus og rotter viste ingen tegn på karcinogent potentiale ved eksponeringer op til 12 gange (mus) og 57 gange (rotter) eksponeringerne hos mennesker ved RHD.
English: insomnia includes: insomnia, initial insomnia and sleep disorder depression includes: depression, depressed mood, major depression, and persistent depressive disorder anxiety includes: anxiety and generalised anxiety disorder abdominal pain includes: abdominal pain, and abdominal pain upper abdominal discomfort includes: abdominal discomfort, and epigastric discomfort faeces soft includes: faeces soft and abnormal faeces.
Danish: insomni inkluderer: insomni, initial insomni og søvnforstyrrelser depression inkluderer: depression, forsænket stemningsleje, major depression (moderat til svær depression) og vedvarende depressive lidelser angst inkluderer: angst og generaliseret angst abdominalsmerter inkluderer: abdominalsmerter og øvre abdominalsmerter abdominalt ubehag inkluderer: abdominalt ubehag og epigastrisk ubehag blød afføring inkluderer: blød afføring og unormal afføring gastrointestinale motilitetsforstyrrelser inkluderer: gastrointestinale motilitetsforstyrrelser og hyppig afføring udslæt inkluderer: udslæt, makuløst udslæt, erytematøst udslæt, generaliseret udslæt, makulopapuløst udslæt, papuløst udslæt og urticaria forhøjet alaninaminotransferase inkluderer: forhøjet alaninaminotransferase og hepatocellulær skade
English: • 90 film-coated tablets (3 bottles of 30 film-coated tablets)
Danish: • 90 filmovertrukne tabletter (3 flasker a 30 filmovertrukne tabletter).
English: Rare: may affect up to 1 in 1,000 people
Danish: Sjælden: kan forekomme hos op til 1 ud af 1.000 personer
English: You may need blood tests to check how your liver is working for 4 months after stopping treatment.
Danish: Det kan være nødvendigt, at du får taget blodprøver i 4 måneder, efter at du er stoppet med behandlingen for at undersøge, hvordan din lever fungerer.
English: • Keep the bottle tightly closed in order to protect from moisture.
Danish: • Hold flasken tæt tillukket for at beskytte mod fugt.
English: Expected: ↑ tenofovir
Danish: Forventet: ↑ tenofovir
English: • joint pain, breakdown of muscle tissue, muscular weakness
Danish: • ledsmerter, nedbrydning af muskelvæv, muskelsvaghed
English: • nafcillin (a medicine to treat some bacterial infections)
Danish: • nafcillin (et lægemiddel til behandling af visse bakterieinfektioner)
English: In DRIVE-FORWARD, 766 subjects were randomised and received at least 1 dose of either doravirine 100 mg or darunavir + ritonavir 800+100 mg once daily, each in combination with emtricitabine/tenofovir disoproxil (FTC/TDF) or abacavir/lamivudine (ABC/3TC) selected by the investigator.
Danish: I DRIVE-FORWARD blev 766 forsøgspersoner randomiseret og fik mindst 1 dosis af enten doravirin 100 mg eller darunavir + ritonavir 800 mg + 100 mg en gang dagligt, hver i kombination med emtricitabin/tenofovirdisoproxil (FTC/TDF) eller abacavir/lamivudin (ABC/3TC) i henhold til investigators valg.
English: Therefore, caution is advised when doravirine/lamivudine/tenofovir disoproxil is administered to patients with severe hepatic impairment (see section 5.2).
Danish: Det tilrådes derfor at udvise forsigtighed, når doravirin/lamivudin/tenofovirdisoproxil administreres til patienter med svært nedsat leverfunktion (se pkt.
English: Vascular disorders Uncommon hypertension
Danish: Vaskulære sygdomme Ikke almindelig hypertension
English: New onset or worsening renal impairment
Danish: Debut eller forværring af nedsat nyrefunktion
English: Single-dose administration of one doravirine/lamivudine/tenofovir disoproxil tablet to healthy subjects (N = 24) under fasted conditions provided comparable exposures of doravirine, lamivudine, and tenofovir to administration of doravirine tablets (100 mg) plus lamivudine tablets (300 mg) plus tenofovir disoproxil tablets (245 mg).
Danish: Enkeltdosis-administration af en doravirin/lamivudin/tenofovirdisoproxil-tablet til raske forsøgspersoner (n=24) i fastende tilstand gav eksponeringer for doravirin, lamivudin og tenofovir, der var sammenlignelige med eksponeringerne ved administration af doravirin-tabletter (100 mg) plus lamivudin-tabletter (300 mg) plus tenofovirdisoproxil-tabletter (245 mg).
English: Always take this medicine exactly as your doctor, pharmacist, or nurse has told you.
Danish: Tag altid lægemidlet nøjagtigt efter lægens, apotekspersonalets eller sygeplejerskens anvisning.
English: This is achieved by adding one 100 mg tablet of doravirine (as a single agent), to be taken approximately 12 hrs apart from the dose of Delstrigo (see section 4.5).
Danish: Dette opnås ved at tilføje en 100 mg tablet doravirin (som enkeltstof), som skal tages ca. 12 timer efter dosis af Delstrigo (se pkt.
English: The Phase 3 studies, DRIVE-FORWARD and DRIVE-AHEAD, included previously untreated patients (n = 747) where the following NNRTI substitutions were part of exclusion criteria: L100I, K101E, K101P, K103N, K103S, V106A, V106I, V106M, V108I, E138A, E138G, E138K, E138Q, E138R, V179L, Y181C, Y181I, Y181V, Y188C, Y188H, Y188L, G190A, G190S, H221Y, L234I, M230I, M230L, P225H, F227C, F227L, F227V.
Danish: Fase 3-studierne, DRIVE-FORWARD og DRIVE-AHEAD, inkluderede tidligere ubehandlede patienter (n=747), hvor følgende NNRTI-substitutioner var del af eksklusionskriterierne: L100I, K101E, K101P, K103N, K103S, V106A, V106I, V106M, V108I, E138A, E138G, E138K, E138Q, E138R, V179L, Y181C, Y181I, Y181V, Y188C, Y188H, Y188L, G190A, G190S, H221Y, L234I, M230I, M230L, P225H, F227C, F227L, F227V.
English: Infections and infestations Rare rash pustular
Danish: Infektioner og parasitære sygdomme Sjælden pustuløst udslæt
English: • ledipasvir/sofosbuvir (medicines used to treat hepatitis C infection)
Danish: • ledipasvir/sofosbuvir (lægemidler til behandling af hepatitis C-infektion)
English: HIV-1 isolates from patients (n = 20) whose HIV-1 expressed a mean of 3 zidovudine associated RT amino acid substitutions (M41L, D67N, K70R, L210W, T215Y/F, or K219Q/E/N) showed a 3.1-fold decrease in the susceptibility to tenofovir.
Danish: Hiv-1-isolater fra patienter (n=20), hvis hiv-1 udtrykte gennemsnitligt 3 zidovudin-associerede RT-aminosyresubstitutioner (M41L, D67N, K70R, L210W, T215Y/F eller K219Q/E/N), viste en 3,1 gange reduktion i følsomheden over for tenofovir.
English: Uncommon disturbance in attention, memory impairment, paraesthesia, hypertonia, poor quality sleep
Danish: Ikke almindelig opmærksomhedsforstyrrelse, hukommelsesbesvær, paræstesi, hypertoni, dårlig søvnkvalitet
English: No dose adjustment of doravirine/lamivudine/tenofovir disoproxil is required in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment.
Danish: Det er ikke nødvendigt at justere dosis af doravirin/lamivudin/tenofovirdisoproxil hos patienter med let nedsat (Child-Pugh-klasse A) eller moderat nedsat (Child-Pugh-klasse B) leverfunktion.
English: Lamivudine was not mutagenic in a microbial mutagenicity assay, in an in vitro cell transformation assay, in a rat micronucleus test, in a rat bone marrow cytogenetic assay, and in an assay for unscheduled DNA synthesis in rat liver.
Danish: Lamivudin var ikke mutagent i en analyse af mikrobiel mutagenicitet, i en in vitro-celletransformationsanalyse, i en rottemikronukleusanalyse, i en cytogenetisk analyse af rotteknoglemarv og i en analyse for uplanlagt DNA-syntese i rottelever.
English: • aggression, hallucinations, difficulty adjusting to changes, mood changes, sleep walking
Danish: • aggression, hallucinationer, besvær med at tilpasse sig forandringer, humørsvingninger,
English: Expected:  doravirine ↑ tenofovir
Danish: Forventet:  doravirin ↑ tenofovir
English: Animal studies with doravirine do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3).
Danish: Dyreforsøg med doravirin indikerer hverken direkte eller indirekte skadelige virkninger, hvad angår reproduktionstoksicitet (se pkt.
English: Alternatives to NSAIDs should be considered, if needed, in patients at risk for renal dysfunction.
Danish: Hos patienter med risiko for dysfunktion af nyrerne skal alternativer til NSAID overvejes, hvis det er nødvendigt.
English: When possible, avoid chronic co-administration of doravirine/lamivudine/tenofovir disoproxil with medicinal products containing sorbitol or other osmotic acting polyalcohols (e.g., xylitol, mannitol, lactitol, maltitol).
Danish: Undgå vedvarende anvendelse af doravirin/lamivudin/tenofovirdisoproxil sammen med sorbitolholdige lægemidler eller andre osmotisk virkende polyalkoholer (f.eks. xylitol, mannitol, lactitol, maltitol), når det er muligt.
English: No dose adjustment of Delstrigo is required in adults with estimated creatinine clearance (CrCl) ≥ 50 mL/min.
Danish: Det er ikke nødvendigt at justere dosis af Delstrigo hos voksne med en estimeret kreatininclearance (CrCl) på ≥ 50 ml/min.
English: Bone abnormalities (infrequently contributing to fractures) may be associated with proximal renal tubulopathy.
Danish: Knogleabnormiteter (i sjældne tilfælde med frakturer til følge) kan være forbundet med proksimal renal tubulopati.
English: What you need to know before you take Delstrigo
Danish: Det skal du vide, før du begynder at tage Delstrigo
English: • difficulty breathing, enlarged tonsils
Danish: • vejrtrækningsproblemer, forstørrede mandler
English: Safety and efficacy of Delstrigo have not been established in patients younger than 18 years of age.
Danish: Pædiatrisk population Delstrigos sikkerhed og virkning hos patienter under 18 år er ikke klarlagt.
English: In DRIVE-AHEAD, 728 subjects were randomized and received at least 1 dose of either doravirine/lamivudine/tenofovir disoproxil 100/300/245 mg (DOR/3TC/TDF) or efavirenz/emtricitabine/tenofovir disoproxil (EFV/FTC/TDF) once daily.
Danish: I DRIVE-AHEAD blev 728 forsøgspersoner randomiseret og fik mindst 1 dosis af enten doravirin/lamivudin/tenofovirdisoproxil 100/300/245 mg (DOR/3TC/TDF) eller efavirenz/emtricitabin/tenofovirdisoproxil (EFV/FTC/TDF) en gang dagligt.
English: Rare hypomagnesaemia, lactic acidosis*
Danish: Sjælden hypomagnesiæmi, lactacidose*
English: • St. John's wort (Hypericum perforatum)
Danish: • perikon (Hypericum perforatum)
English: • Doravirine - a non-nucleoside reverse transcriptase inhibitor (NNRTI)
Danish: • doravirin - en non-nukleosid revers transkriptasehæmmer (NNRTI)
English: Doravirine has not been studied in patients with severe hepatic impairment (Child-Pugh Class C).
Danish: Doravirin er ikke undersøgt hos patienter med svært nedsat leverfunktion (Child-Pugh-klasse C).
English: Nervous system disorders Common headache, dizziness, somnolence
Danish: Nervesystemet Almindelig hovedpine, svimmelhed, døsighed
English: • lactic acidosis (excess lactic acid in the blood)
Danish: • lactacidose (for meget mælkesyre i blodet)
English: Skin and subcutaneous tissue disorders Common alopecia*, rash
Danish: Hud og subkutane væv Almindelig alopeci*, udslæt
English: Long-term oral carcinogenicity studies of doravirine in mice and rats showed no evidence of carcinogenic potential at estimated exposures up to 6 times (mice) and 7 times (rats) the human exposures at the RHD.
Danish: Langtidskarcinogenicitetsstudier af oralt administreret doravirin hos mus og rotter viste ingen tegn på karcinogent potentiale ved estimerede eksponeringer op til 6 gange (mus) og 7 gange (rotter) eksponeringerne hos mennesker ved RHD.
English: Rare aggression, hallucination, adjustment disorder, mood altered, somnambulism
Danish: Sjælden aggression, hallucinationer, tilpasningsforstyrrelse, ændret stemningsleje, søvngængeri
English: Rare acute kidney injury, renal disorder, calculus urinary, nephrolithiasis, acute renal failure*, renal failure*, acute tubular necrosis*, nephritis (including acute interstitial)*, nephrogenic diabetes insipidus*
Danish: Sjælden akut nyreskade, nyresygdom, sten i urinvejene, nefrolitiasis, akut nyresvigt*, nyresvigt*, akut tubulær nekrose*, nefritis (herunder akut interstitiel)*, nefrogen diabetes insipidus* Almene symptomer og reaktioner på administrationsstedet Almindelig træthed, feber*
English: Doravirine has not been studied in patients with end-stage renal disease or in patients undergoing dialysis (see section 4.2).
Danish: Doravirin er ikke undersøgt hos patienter med terminal nyresygdom (ESRD) eller hos patienter i dialysebehandling (se pkt.
English: The pharmacokinetic properties of lamivudine have been determined in subjects with moderate to severe hepatic impairment.
Danish: Lamivudins farmakokinetiske egenskaber er blevet bestemt hos forsøgspersoner med moderat til svært nedsat leverfunktion.
English: Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphataemia), has been reported with the use of tenofovir disoproxil, a component of Delstrigo.
Danish: Der er rapporteret nedsat nyrefunktion, herunder tilfælde af akut nyresvigt og Fanconis syndrom (beskadigede nyretubuli med svær hypofosfatæmi), ved anvendelse af tenofovirdisoproxil, som er en komponent i Delstrigo.
English: • headache, dizziness, sleepiness
Danish: • hovedpine, svimmelhed, søvnighed
English: The K70E substitution selected clinically by tenofovir disoproxil results in reduced susceptibility to abacavir, didanosine, emtricitabine, lamivudine, and tenofovir.
Danish: K70E-substitutionen, der blev selekteret for ved klinisk anvendelse af tenofovirdisoproxil, resulterer i nedsat følsomhed over for abacavir, didanosin, emtricitabin, lamivudin og tenofovir.
English: Doravirine was not genotoxic in a battery of in vitro or in vivo assays.
Danish: Doravirin Doravirin var ikke genotoksisk i en række in vitro- og in vivo-analyser.