FrancophonIA/ELRC3.0 huggingface dataset:
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete,ste pred kratkim jemali ali pa boste morda začeli jemati katerokoli drugo zdravilo.
English: VIAGRA may have a minor influence on the ability to drive and use machines.
Slovenian: Zdravilo VIAGRA ima lahko blag vpliv na sposobnost vožnje in upravljanja strojev.
English: If you feel that the effect of VIAGRA is too strong or too weak, talk to your doctor or pharmacist.
Slovenian: Če občutite, da je učinek zdravila VIAGRA premočan ali prešibak, se posvetujte z zdravnikom ali farmacevtom.
English: What VIAGRA is and what it is used for
Slovenian: Kaj je zdravilo VIAGRA in za kaj ga uporabljamo
English: If you have a severe heart or liver problem.
Slovenian: Če imate hude težave s srcem ali jetri.
English: VIAGRA is indicated in adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.
Slovenian: Zdravilo VIAGRA je indicirano pri odraslih moških z erektilno disfunkcijo, tj. nezmožnostjo doseči ali ohraniti erekcijo penisa, ki bi zadoščala za zadovoljivo spolno aktivnost.
English: This is most likely to happen within 4 hours after taking VIAGRA.
Slovenian: Največja verjetnost, da se to zgodi, je v 4 urah po zaužitju zdravila VIAGRA.
English: If a dose of 25 mg is required, the use of the 25 mg film-coated tablets should be recommended.
Slovenian: Če je potreben 25 mg odmerek, je priporočena uporaba 25 mg filmsko obloženih tablet.
English: Place the orodispersible tablet in the mouth, on the tongue, where it will dissolve in seconds, then swallow with saliva or water.
Slovenian: Orodisperzibilno tableto položite v usta, na jezik, kjer se bo raztopila v nekaj sekundah, nato pogoltnite s slino ali vodo.
English: In the same study, the AUC was unchanged but the mean Cmax was 14% lower when 50 mg orodispersible tablets were administered with water compared to 50 mg film-coated tablet.
Slovenian: V isti študiji je bil AUC nespremenjen, vendar je povprečna Cmax bila za 14 % nižja, če je bila 50 mg orodisperzibilna tableta zaužita z vodo v primerjavi s 50 mg filmsko obloženo tableto.
English: VIAGRA can be taken with or without food.
Slovenian: Zdravilo VIAGRA lahko zaužijete s hrano ali brez nje.
English: Paediatric population VIAGRA is not indicated for individuals below 18 years of age.
Slovenian: Pediatrična populacija Zdravilo VIAGRA ni indicirano pri mlajših od 18 let.
English: VIAGRA potentiates the hypotensive effect of nitrates (see section 4.3).
Slovenian: Zdravilo VIAGRA okrepi hipotenzivni učinek nitratov (glejte poglavje 4.3).
English: Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu poleg oznake »EXP:«.
English: Recommend tablet be taken on an empty stomach.
Slovenian: Tableto je priporočljivo vzeti na prazen želodec.
English: Viagra should be taken as needed approximately one hour before sexual activity.
Slovenian: Zdravilo VIAGRA je treba vzeti, kot je potrebno, približno eno uro pred spolno dejavnostjo.
English: If VIAGRA does not help you to get an erection, or if your erection does not last long enough for you to complete sexual intercourse you should tell your doctor.
Slovenian: Če vam zdravilo VIAGRA ne pomaga doseči erekcije ali dosežena erekcija ne traja dovolj dolgo za popoln spolni odnos, morate to povedati zdravniku.
English: Some pack sizes may not be marketed in your country.
Slovenian: V vaši državi na tržišču morda ni vseh pakiranj.
English: The orodispersible tablets should be taken on an empty stomach as you may find that it takes longer to start working if you take it with a heavy meal.
Slovenian: Orodisperzibilne tablete je treba vzeti na prazen želodec, saj je potrebno več časa za začetek delovanja zdravila, če ga vzamete skupaj z obilnim obrokom.
English: As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery.
Slovenian: V kliničnih preskušanjih s sildenafilom so poročali o omotici in spremembah vida, zato se morajo bolniki zavedati, kako se odzovejo na zdravilo VIAGRA, preden vozijo ali upravljajo s stroji.
English: Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes.
Slovenian: Ker je največja koncentracija sildenafila v plazmi po priporočenih odmerkih približno 1 µM, ni verjetno, da bi zdravilo VIAGRA spremenilo očistek substratov teh izoencimov.
English: Dissolve in the mouth.
Slovenian: Raztopite tableto v ustih.
English: It is recommended that orodispersible tablets be taken on an empty stomach.
Slovenian: Priporočeno je, da se orodisperzibilne tablete jemljejo na prazen želodec.
English: The side effects reported in association with the use of VIAGRA are usually mild to moderate and of a short duration.
Slovenian: Neželeni učinki o katerih poročajo v zvezi z uporabo zdravila VIAGRA so ponavadi blagi do zmerni in se pojavijo za kratek čas.
English: What you need to know before you take VIAGRA
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo VIAGRA
English: The recommended dose is 50 mg taken on an empty stomach as concomitant intake with food delays absorption and delays the effect of the orodispersible tablet (see section 5.2).
Slovenian: Priporočeni odmerek je 50 mg na prazen želodec, saj sočasno zaužitje s hrano upočasni absorpcijo in zakasni učinek orodisperzibilnih tablet (glejte poglavje 5.2).
English: You should not take VIAGRA if you do not have erectile dysfunction.
Slovenian: Zdravila VIAGRA ne smete jemati, če nimate erektilne disfunkcije.
English: If you require a second 50 mg orodispersible tablet to make a 100 mg dose, you should wait until the first one has completely disintegrated and you have swallowed it before taking the second orodispersible tablet.
Slovenian: Če potrebujete še eno 50 mg orodisperzibilno tableto, da je odmerek 100 miligramski, morate počakati, da prva tableta popolnoma razpade in da ste jo pogoltnili, preden vzamete drugo orodisperzibilno tableto.
English: Patients should be advised that in the event of any sudden visual defect, they should stop taking VIAGRA and consult a physician immediately (see section 4.3).
Slovenian: Bolnika je treba opozoriti, da naj v primeru kakršnekoli nenadne okvare vida preneha jemati zdravilo VIAGRA in o tem nemudoma obvesti svojega zdravnika (glejte poglavje 4.3).
English: After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%).
Slovenian: Po enkratnem 100 mg peroralnem odmerku je srednja največja celotna koncentracija sildenafila v plazmi približno 440 ng/ml (CV 40 %).
English: To get the maximum benefit from your medicine, you are advised not to drink excessive amounts of alcohol before taking VIAGRA.
Slovenian: Za največji učinek vašega zdravila vam priporočamo, da ne uživate prevelikih količin alkohola pred zaužitjem zdravila VIAGRA.
English: Epidermal Necrolysis (TEN)*
Slovenian: Stevens-Johnsonov sindrom (SJS)*, toksična epidermalna nekroliza (TEN)*
English: Do not take VIAGRA with other medicines unless your doctor tells you that you can.
Slovenian: Zdravila VIAGRA ne uporabljajte skupaj z drugimi zdravili, razen čevam zdravnik pove, da ga lahko.
English: - Do not use nitrates to treat your chest pain.
Slovenian: Ne vzemite nitratov, ki jih uporabljate za bolečine v prsnem košu.
English: • Seizures or fits - this occurs rarely
Slovenian: •Konvulzije ali napadi -to se zgodi redko
English: Due to age-differences in plasma protein binding, the corresponding increase in free sildenafil plasma concentration was approximately 40%.
Slovenian: Zaradi starostno pogojenih razlik v vezavi na beljakovine v plazmi so se plazemske koncentracije prostega sildenafila ustrezno zvečale za približno 40 %.
English: VIAGRA will only help you to get an erection if you are sexually stimulated.
Slovenian: Zdravilo VIAGRA vam bo pomagalo doseči erekcijo le, če ste spolno stimulirani.
English: Other medicines and VIAGRA
Slovenian: Druga zdravila in zdravilo VIAGRA
English: The maximum recommended dose is 100 mg. For patients requiring a dose increase to 100 mg, two 50 mg orodispersible tablets should be administered sequentially.
Slovenian: Največji priporočeni odmerek je 100 mg. Bolniki, ki potrebujejo zvišanje odmerka na 100 mg, morajo zaporedno vzeti dve 50 mg orodisperzibilni tableti.
English: If you currently have a stomach ulcer, or a bleeding problems (such as haemophilia).
Slovenian: Če imate trenutno razjedo na želodcu ali če imate težave, povezane s krvavitvami (npr. hemofilijo).
English: Some patients who take alpha-blocker therapy for the treatment of high blood pressure or prostate enlargement may experience dizziness or light-headedness, which may be caused by low blood pressure upon sitting or standing up quickly.
Slovenian: Nekatere bolnike, ki jemljejo antagonist adrenergičnih receptorjev alfa za zdravljenje visokega krvnega tlaka ali zaradi povečanja prostate, lahko v stoječem položaju obide omotica ali vrtoglavica, kot posledica nizkega krvnega tlaka, ki se pojavi med sedenjem ali če hitro vstanete.
English: If you have ever had loss of vision due to non-arteritic anterior ischaemic optic neuropathy (NAION).
Slovenian: Če ste kadarkoli izgubili vid zaradi nearteritične anteriorne ishemične optične nevropatije (NAION).
English: VIAGRA is a treatment for adult men with erectile dysfunction, sometimes known as impotence.
Slovenian: Zdravilo VIAGRA je zdravilo za odrasle moške z erektilno disfunkcijo, znano tudi kot impotenca.
English: Table 1: Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance
Slovenian: Preglednica 1: Medicinsko pomembni neželeni učinki, o katerih so v nadzorovanih kliničnih študijah poročali z večjo pogostnostjo kot pri placebu in medicinsko pomembni neželeni učinki, o katerih so poročali v obdobju trženja.
English: The film coating of the tablet contains lactose.
Slovenian: Filmska obloga tablet zdravila vsebuje laktozo.
English: Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM).
Slovenian: Ker je sildenafil (in njegov glavni krožeči Ndesmetilni presnovek) 96 % vezan na beljakovine v plazmi, je srednja največja koncentracija prostega sildenafila v plazmi 18 ng/ml (38 nM).
English: VIAGRA is not indicated for use by women.
Slovenian: Zdravilo VIAGRA ni indicirano za uporabo pri ženskah.
English: • Chest pains - this occurs uncommonly If this occurs during or after intercourse - Get in a semi-sitting position and try to relax.
Slovenian: • Bolečine v prsnem košu - to se zgodi občasno Če se to zgodi med ali po spolnem odnosu Se namestite v polsedeči položaj in se poskusite sprostiti.
English: • Serious skin reactions - this occurs rarely Symptoms may include severe peeling and swelling of the skin, blistering of the mouth, genitals and around the eyes, fever.
Slovenian: • Resne kožne reakcije - to se zgodi redko Simptomi lahko vključujejo hudo lupljenje in otekanje kože, mehurčke na ustih, spolovilu in okoli oči, vročino.
English: In a clinical study in 36 healthy males 45 years or older, 50 mg orodispersible tablets administered without water were observed to be bioequivalent to the 50 mg film-coated tablets.
Slovenian: V klinični študiji na 36 zdravih moških, starih 45 let ali več, so primerjali 50 mg orodisperzibilne tablete, ki so jih zaužili brez vode, s 50 mg filmsko obloženimi tabletami, da bi ugotovili biološko enakovrednost.
English: The orodispersible tablet should be placed in the mouth, on the tongue, and allowed to disintegrate before swallowing with or without water.
Slovenian: Orodisperzibilno tableto se položi v usta, na jezik, kjer se tableta razpusti preden se jo pogoltne z ali brez vode.
English: If you experience any of the following serious side effects stop taking VIAGRA and seek medical help immediately:
Slovenian: Če opazite katerega od naslednjih resnih neželenih učinkov, prenehajte jemati zdravilo in nemudoma poiščite zdravniško pomoč:
English: It should be taken immediately upon removal from the blister.
Slovenian: Tableto je treba zaužiti takoj, ko se jo odstrani iz pretisnega omota.
English: The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: severe hepatic impairment, hypotension (blood pressure <90/50 mmHg), recent history of stroke or myocardial infarction and known hereditary degenerative retinal disorders such as retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases).
Slovenian: Varnost sildenafila ni raziskana pri naslednjih podskupinah bolnikov, pri katerih je njegova uporaba zato kontraindicirana: huda okvara jeter, hipotenzija (krvni tlak < 90/50 mmHg), nedavna možganska kap ali miokardni infarkt in znane dedne degenerativne bolezni mrežnice, npr. retinitis pigmentosa (manjši del teh bolnikov ima genetske motnje mrežničnih fosfodiesteraz).
English: What VIAGRA is and what it is used for What you need to know before you take VIAGRA How to take VIAGRA
Slovenian: Kaj je zdravilo VIAGRA in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo VIAGRA Kako jemati zdravilo VIAGRA Možni neželeni učinki
English: You should not use VIAGRA with any other oral or local treatments for erectile dysfunction.
Slovenian: Hkrati z zdravilom VIAGRA ne smete uporabljati nobenega drugega zdravila za peroralno ali lokalno uporabo za zdravljenje erektilne disfunkcije.
English: Certain patients have experienced these symptoms when taking VIAGRA with alpha-blockers.
Slovenian: Nekateri bolniki so doživeli takšne simptome med jemanjem zdravila VIAGRA z antagonisti adrenergičnih receptorjev alfa.
English: You should not use VIAGRA with treatments for pulmonary arterial hypertension (PAH) containing sildenafil or any other PDE5 inhibitors.
Slovenian: Zdravila VIAGRA ne smete uporabljati skupaj z zdravili za zdravljenje pljučne arterijske hipertenzije (PAH), ki vsebujejo sildenafil ali katerekoli druge zaviralce PDE5.
English: If you experience sudden decrease or loss of vision, stop taking VIAGRA and contact your doctor immediately.
Slovenian: Če doživite nenadno poslabšanje ali izgubo vida, prenehajte jemati zdravilo VIAGRA in se takoj obrnite na zdravnika.
English: For patients requiring a second 50 mg orodispersible tablet to make a 100 mg dose, the second tablet should be taken upon full disintegration of the first tablet.
Slovenian: Bolniki, ki potrebujejo še eno 50 mg orodisperzibilno tableto, da bo odmerek 100 miligramski, morajo drugo tableto vzeti po popolnem razpadu prve tablete.
English: Do not take VIAGRA film-coated tablets in combination with VIAGRA orodispersible tablets.
Slovenian: Ne jemljite zdravila VIAGRA filmsko obložene tablete v kombinaciji z zdravilom VIAGRA orodisperzibilne tablete.
English: The manufacturer of VIAGRA is Fareva Amboise, Zone Industrielle, 29 route des Industries, 37530 Pocé-sur-Cisse, France.
Slovenian: Zdravilo VIAGRA izdeluje Fareva Amboise, Zone Industrielle, 29 route des Industries, 37530 Pocésur-Cisse, Francija.
English: In volunteers with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min), the pharmacokinetics of sildenafil were not altered after receiving a 50 mg single oral dose.
Slovenian: Pri prostovoljcih z blago do zmerno okvaro ledvic (očistek kreatinina = 30 do 80 ml/min) farmakokinetika sildenafila po enkratnem 50 mg peroralnem odmerku ni bila spremenjena.
English: VIAGRA with alcohol
Slovenian: Zdravilo VIAGRA skupaj z alkoholom
English: In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n=9), sildenafil (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress).
Slovenian: V majhni s placebom nadzorovani študiji pri bolnikih s potrjeno zgodnjo starostno degeneracijo makule (n = 9) sildenafil v enkratnem 100 mg odmerku ni imel pomembnega vpliva na preiskave vida (ostrina vida, Amslerjeva mrežica, ločevanje barv na simuliranem semaforju, Humphreyev perimeter in fotostres).
English: Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: psychogenic erectile dysfunction (84%), mixed erectile dysfunction (77%), organic erectile dysfunction (68%), elderly (67%), diabetes mellitus (59%), ischaemic heart disease (69%), hypertension (68%), TURP (61%), radical prostatectomy (43%), spinal cord injury (83%), depression (75%).
Slovenian: V vseh preskušanjih skupaj so bili deleži bolnikov, ki so s sildenafilom navajali izboljšanje, naslednji: psihogena erektilna disfunkcija (84 %), mešana erektilna disfunkcija (77 %), organska erektilna disfunkcija (68 %), starostniki (67 %), sladkorna bolezen (59 %), ishemična bolezen srca (69 %), zvišan krvni tlak (68 %), transuretralna resekcija prostate (61 %), radikalna prostatektomija (43 %), poškodba hrbtenjače (83 %), depresija (75 %).
English: The mean AUC and Cmax of the N-desmethyl metabolite increased up to 126% and up to 73% respectively, compared to age-matched volunteers with no renal impairment.
Slovenian: Srednja AUC N-desmetilnega presnovka se je zvečala za do 126 %, srednji Cmax pa za do 73 % v primerjavi s prostovoljci primerljive starosti brez okvare ledvic.
English: VIAGRA should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Slovenian: Zdravila VIAGRA ne smemo uporabiti pri bolnikih z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze.
English: Do not take VIAGRA orodispersible tablets in combination with film-coated tablets containing sildenafil including VIAGRA film-coated tablets.
Slovenian: Ne jemljite zdravila VIAGRA orodisperzibilne tablete v kombinaciji s filmsko obloženimi tabletami, ki vsebujejo sildenafil, vključno z zdravilom VIAGRA filmsko obložene tablete.
English: The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension (PAH) treatments containing sildenafil (REVATIO), or other treatments for erectile dysfunction have not been studied.
Slovenian: Varnost in učinkovitost kombinacije sildenafila z drugimi zaviralci PDE5, drugimi zdravili proti pljučni arterijski hipertenziji (PAH), ki vsebujejo sildenafil (REVATIO), ali drugimi zdravili za zdravljenje erektilne disfunkcije nista raziskani, zato uporaba takih kombinacij ni priporočena.
English: Do not take VIAGRA
Slovenian: Ne jemljite zdravila VIAGRA
English: In a study of the hemodynamic effects of a single oral 100 mg dose of sildenafil in 14 patients with severe coronary artery disease (CAD) (>70% stenosis of at least one coronary artery), the mean resting systolic and diastolic blood pressures decreased by 7% and 6% respectively compared to baseline.
Slovenian: V študiji hemodinamičnih učinkov enkratnega peroralnega 100 mg odmerka sildenafila pri 14 bolnikih s hudo boleznijo koronarnih arterij (> 70 % stenoza vsaj ene koronarne arterije) se je srednji sistolični tlak v mirovanju v primerjavi z izhodiščem znižal za 7 %, povprečni diastolični tlak v mirovanju pa za 6 %.
English: Warnings and precautions Talk to your doctor, pharmacist or nurse before taking VIAGRA If you have sickle cell anaemia (an abnormality of red blood cells), leukaemia (cancer of blood cells), multiple myeloma (cancer of bone marrow).
Slovenian: Pred začetkom jemanja zdravila VIAGRA se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro: Če imate srpastocelično anemijo (nepravilnost rdečih krvnih celic), levkemijo (rak krvnih celic), multipli mielom (rak kostnega mozga).
English: Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 μM).
Slovenian: Sildenafil je šibek zaviralec izoencimov 1A2, 2C9, 2C19, 2D6, 2E1 in 3A4 citokroma P450 (IC50 > 150 µM).
English: VIAGRA contains the active substance sildenafil which belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors.
Slovenian: Zdravilo VIAGRA vsebuje zdravilno učinkovino sildenafil, ki sodi med zdravila, ki jih imenujemo zaviralci fosfodiesteraze tipa 5 (PDE5).
English: Glycerol (E422) Propylene glycol (E1520)
Slovenian: Naravna aroma: maltodekstrin glicerol (E422) propilenglikol (E1520)
English: If you are taking medicines known as protease inhibitors, such as for the treatment of HIV, your doctor may start you on the lowest dose (25 mg) of VIAGRA.
Slovenian: Če jemljete zdravila, ki so znana kot zaviralci proteaz, npr. za zdravljenje okužbe s HIV, vam bo zdravnik uvodoma morda predpisal najmanjši odmerek (25 mg) zdravila VIAGRA.
English: In the event of a medical emergency, you should tell your doctor, pharmacist or nurse that you have taken VIAGRA and when you did.
Slovenian: V primeru nujne zdravstvene obravnave moratepovedati zdravniku, farmacevtu ali medicinski sestri, da ste vzeli zdravilo VIAGRA in kdaj ste ga vzeli.
English: VIAGRA tablets may interfere with some medicines, especially those used to treat chest pain.
Slovenian: Zdravilo VIAGRA lahko medsebojno deluje z nekaterimi zdravili, zlasti s tistimi, ki se uporabljajo proti angini pektoris.
English: In healthy volunteers receiving sildenafil (100 mg single dose), less than 0.0002% (average 188 ng) of the administered dose was present in ejaculate 90 minutes after dosing.
Slovenian: Pri zdravih prostovoljcih, ki so dobili sildenafil (en 100 mg odmerek), je bilo v ejakulatu 90 minut po uporabi manj kot 0,0002 % (povprečno 188 ng) uporabljenega odmerka.
English: The other ingredients are: microcrystalline cellulose, silica hydrophobic colloidal, croscarmellose sodium, magnesium stearate, indigo carmine aluminium lake (E132), sucralose, mannitol, crospovidone, polyvinyl acetate, povidone, flavouring containing: maltodextrin and dextrin, natural flavouring containing: maltodextrin, glycerol (E422) and propylene glycol (E1520), lemon flavouring containing: maltodextrin and alpha-tocopherol (E307)).
Slovenian: Druge sestavine zdravila so: mikrokristalna celuloza, hidrofobni koloidni silicijev dioksid, premreženi natrijev karmelozat, magnezijev stearat, indigotin (E132), sukraloza, manitol, krospovidon, polivinil acetat, povidon; aroma vsebuje: maltodekstrin, dekstrin; naravna aroma vsebuje: maltodekstrin, glicerol (E422), propilenglikol (E1520); aroma limone vsebuje: maltodekstrin, alfa-tokoferol (E307).
English: VIAGRA is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure (see section 4.4).
Slovenian: Zdravilo VIAGRA je kontraindicirano pri bolnikih, ki so izgubili vid na enem očesu zaradi nearteritične anteriorne ishemične optične nevropatije (NAION), tudi če ta dogodek ni bil povezan s predhodnim jemanjem zaviralcev PDE5 (glejte poglavje 4.4).
English: In volunteers with severe renal impairment (creatinine clearance <30 mL/min), sildenafil clearance was reduced, resulting in mean increases in AUC and Cmax of 100% and 88% respectively compared to age-matched volunteers with no renal impairment.
Slovenian: Pri prostovoljcih s hudo okvaro ledvic (očistek kreatinina < 30 ml/min) se je očistek sildenafila zmanjšal, to pa je povzročilo povprečno zvečanje AUC za 100 % in Cmax za 88 % v primerjavi s prostovoljci primerljive starosti brez okvare ledvic.