FrancophonIA/ELRC3.0 huggingface dataset:
English: The adverse reactions are classified by System Organ Class and frequency, using the following convention: Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to < /100), Rare (≥ 1/10,000 to < 1/1,000), Very rare (< 1/10,000), not known (cannot be estimated from the available data)
Croatian: Nuspojave su klasificirane po organskim sustavima i učestalosti, prema sljedećoj konvenciji: vrlo često (≥ 1/10), često (≥ 1/100 do < 1/10), manje često (≥ 1/1000 do < 1/100), rijetko (≥ 1/10 000 do < 1/1000), vrlo rijetko (< 1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: The product is for a single examination only.
Croatian: Ovaj proizvod namijenjen je samo jednom pregledu.
English: SonoVue is given to you by medical or healthcare professionals who are experienced in this type of examination.
Croatian: SonoVue Vam daju medicinski ili zdravstveni djelatnici s iskustvom u ovoj vrsti pregleda.
English: As a precautionary measure, it is preferable to avoid the use of SonoVue during pregnancy.
Croatian: Kao mjeru opreza, poželjno je izbjegavati primjenu lijeka SonoVue tijekom trudnoće.
English: Myocardial infarction** Myocardial ischemia**
Croatian: Infarkt miokarda** Ishemija miokarda**
English: Before use examine the product to ensure that the container and closure have not been damaged.
Croatian: Prije uporabe pregledajte lijek kako biste se uvjerili da spremnik i zatvarač nisu oštećeni.
English: Once reconstituted, chemical and physical stability has been demonstrated for 6 hours.
Croatian: Nakon rekonstitucije, kemijska i fizikalna stabilnost je dokazana tijekom 6 sati.
English: However, some patients may experience serious side effects and may require treatment.
Croatian: Međutim, neki bolesnici mogu doživjeti ozbiljne nuspojave koje mogu zahtijevati liječenje.
English: Shake vigorously for 20 seconds to mix all the contents in the vial to obtain a white milky homogeneous liquid.
Croatian: Snažno protresite 20 sekundi kako bi se pomiješao sav sadržaj bočice i kako bi dobili bijelu mliječnu homogenu tekućinu.
English: • Vascular Doppler imaging: 2.4 mL.
Croatian: • Snimanje žila dopplerom: 2,4 ml.
English: After reconstitution, SonoVue is a homogeneous white milky dispersion.
Croatian: Nakon rekonstitucije, lijek SonoVue je homogena bijela mliječna disperzija.
English: Caecal lesions observed in some repeat-dose studies with rats, but not in monkeys, are not relevant for humans under normal conditions of administration.
Croatian: Lezije cekuma primijećene u nekim ispitivanjima s ponovljenim dozama na štakorima, ali ne i na majmunima, nisu relevantne za ljude u propisanim uvjetima primjene.
English: More than 80% of the administered sulphur hexafluoride was recovered in exhaled air within 2 minutes after injection and almost 100% after 15 minutes.
Croatian: Više od 80% primijenjenog sumporovog heksafluorida izlučilo se u izdahnutom zraku u 2 minute nakon injiciranja, a gotovo 100% nakon 15 minuta.
English: Ultrasonography of excretory urinary tract
Croatian: Ultrasonografija ekskretornog urinarnog trakta
English: Do not use if the liquid obtained is clear and/or if solid parts of the lyophilisate are seen in the suspension.
Croatian: Nemojte koristiti ako je dobivena tekućina prozirna i/ili ako se u disperziji vide čvrste čestice liofilizata.
English: No clinical data on exposed pregnancies are available.
Croatian: Nisu dostupni klinički podaci o izloženosti u trudnoći.
English: Animal studies do not indicate harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3 Preclinical safety data).
Croatian: Ispitivanja na životinjama ne upućuju na štetne učinke na trudnoću, embrionalni/fetalni razvoj, porod ili postnatalni razvoj (vidjeti dio 5.3 Neklinički podaci o sigurnosti primjene).
English: The medicinal product does not require any special storage conditions.
Croatian: Lijek ne zahtijeva posebne uvjete čuvanja.
English: Via Ribes 5, Bioindustry Park Colleretto Giacosa - 10010 (TO) Italy
Croatian: Bracco Imaging S.p.A. Via Ribes 5, Bioindustry Park Colleretto Giacosa - 10010 (TO) Italija
English: What you need to know before you are given SonoVue
Croatian: Što morate znati prije nego primite SonoVue
English: Most of the side effects to SonoVue are rare and usually not serious.
Croatian: Većina nuspojava lijeka SonoVue su rijetke i obično nisu ozbiljne.
English: What SonoVue looks like and contents of the pack
Croatian: Kako SonoVue izgleda i sadržaj pakiranja
English: SonoVue is for diagnostic use only.
Croatian: SonoVue se koristi samo u dijagnostičke svrhe.
English: If you have a serious pulmonary or cardiac condition you will be under close medical supervision during and for at least 30 minutes after the injection of SonoVue.
Croatian: Ako imate ozbiljnu plućnu ili srčanu bolest, bit ćete pod strogim medicinskim nadzorom tijekom i najmanje 30 minuta nakon ubrizgavanja lijeka SonoVue.
English: Bracco International B.V., Strawinskylaan 3051, NL - 1077 ZX Amsterdam, The Netherlands
Croatian: Bracco International B.V., Strawinskylaan 3051, NL - 1077 ZX Amsterdam, Nizozemska
English: What SonoVue is and what it is used for
Croatian: Što je SonoVue i zašto se koristi
English: The microbubbles have a mean diameter of about 2.5 µm, with 90% having a diameter less than 6 µm and 99% having a diameter less than 11 µm.
Croatian: Mikromjehurići imaju prosječan promjer od oko 2,5 µm, pri tom 90% ima promjer manji od 6 µm, a 99% ima promjer manji od 11 µm.
English: Marketing authorisation holder Bracco International B.V.
Croatian: Nositelj odobrenja za stavljanje lijeka u promet Bracco International B.V.
English: What SonoVue is and what it is used for What you need to know before you are given SonoVue How SonoVue is given
Croatian: Što je SonoVue i za što se koristi Što morate znati prije nego primite SonoVue Kako davati SonoVue
English: The safety of SonoVue after intravenous administration was evaluated in 4653 adult patients who participated in 58 clinical trials.
Croatian: Sigurnost lijeka SonoVue nakon intravenske primjene ocijenjena je na 4653 odraslih bolesnika koji su sudjelovali u 58 kliničkih ispitivanja.
English: For ultrasound scan of heart or your blood vessels and/or tissues of the liver and breast in adults:the dose to be administered into a vein will be calculated for you depending on which part of your body is being examined.
Croatian: Za ultrazvučno snimanje srca ili Vaših krvnih žila i/ili tkiva jetre i dojki u odraslih: doza koja treba biti primijenjena u venu će se izračunati za Vas ovisno o tome koji dio Vašeg tijela se pregledava.
English: Chemical and physical stability of the microbubble dispersion has been demonstrated for 6 hours.
Croatian: Kemijska i fizikalna stabilnost disperzije mikromjehurića dokazana je tijekom 6 sati.
English: Headache, paraesthesia, dizziness, dysgeusia
Croatian: Glavobolja, parestezija, omaglica, disgeuzija
English: MARKETING AUTHORISATION NUMBERS EU/1/01/177/002
Croatian: ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/01/177/002
English: In patients with diffuse interstitial pulmonary fibrosis, the percent of dose recovered in expired air averaged 100% and the terminal half-life was similar to that measured in healthy volunteers.
Croatian: Kod bolesnika s difuznom intersticijskom plućnom fibrozom, postotak doze koja se izlučila u izdahnutom zraku bio je u prosjeku 100%, a terminalni poluvijek sličan onome izmjerenom kod zdravih dobrovoljaca.
English: However, based on its rapid elimination from the body via the expired air, it is considered that the breastfeeding can be resumed two to three hours after administration of SonoVue.
Croatian: Međutim, zbog njegove brze eliminacije iz tijela izdahnutim zrakom, smatra se da se dojenje može nastaviti dva do tri sata nakon primjene lijeka SonoVue.
English: After a single intravenous injection of 0.03 or 0.3 mL of SonoVue/kg (approximately 1 and 10 times the maximum clinical dose) to human volunteers, the sulphur hexafluoride was cleared rapidly.
Croatian: Nakon jedne intravenske injekcije 0,03 ili 0,3 ml lijeka SonoVue/kg dobrovoljcima (približno 1 i 10 puta maksimalne kliničke doze), sumporov heksafluorid se brzo uklonio.
English: The presence or absence of vesicoureteral reflux with SonoVue ultrasound was compared to the radiographic reference standard.
Croatian: Prisutnost ili odsutnost vesikoureteralnog refluksa kod SonoVue ultrazvuka bila je uspoređena s radiografskim referentnim standardom.
English: Tell your doctor straight away if you notice any of the following side effects, you may need medical treatment: swelling of the face, lips, mouth or throat which may make it difficult to swallow or breathe; skin rash; hives; swelling of the hands, feet or ankles.
Croatian: Odmah recite liječniku ako primijetite bilo koju od sljedećih nuspojava, možda trebate hitno medicinsko liječenje: oticanje lica, usana, usta ili grla što može otežati gutanje ili disanje; osip kože; koprivnjača; oticanje šaka, stopala ili gležnjeva.
English: Hypersensitivity*
Croatian: Preosjetljivost*
English: If you are given SonoVue together with a medicine, exercise or a device that stimulates the heart in order to visualise your heart under stress work, your heart activity, your blood pressure and rhythm will be monitored.
Croatian: Ako primate SonoVue zajedno s lijekom, uz vježbanje ili uređaj koji potiče rad srca kako bi se dobio prikaz Vašeg srca pod stresom, pratit će se aktivnost Vašeg srca, krvni tlak i srčani ritam.
English: This product should only be used by physicians experienced in diagnostic ultrasound imaging.
Croatian: Ovaj lijek smiju koristiti samo liječnici koji imaju iskustva u oslikavanju dijagnostičkim ultrazvukom.
English: Marketing Authorisation Holder and Manufacturer:
Croatian: Nositelj odobrenja za stavljanje lijeka u promet i proizvođač:
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Croatian: Od zdravstvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava: navedenog u Dodatku V*.
English: Outer packaging
Croatian: Vanjsko pakiranje
English: No adverse reactions were reported.
Croatian: Nije bilo prijavljenih nuspojava.
English: If you are given more SonoVue than you should
Croatian: Ako Vam je dano više lijeka SonoVue nego što je trebalo
English: Final study report to be submitted by 2Q 2020
Croatian: Završno izvješće ispitivanja treba predati do 2. kvartala
English: In very rare cases, fatal outcomes have been reported in temporal association with the use of SonoVue.
Croatian: U vrlo rijetkim slučajevima, prijavljeni su fatalni ishodi vremenski povezani s primjenom lijeka SonoVue.
English: Sulphur hexafluoride is an inert, innocuous gas, poorly soluble in aqueous solutions.
Croatian: Sumporov heksafluorid je inertan, neškodljiv plin, slabo topljiv u vodenim otopinama.
English: What SonoVue contains
Croatian: Što SonoVue sadrži
English: Pharmacotherapeutic group: Ultrasound contrast media ATC code: VO8DA05.
Croatian: Farmakoterapijska skupina: ultrazvučna kontrastna sredstva ATK oznaka: V08DA05.
English: 4.6 Pregnancy, lactation, and fertility
Croatian: 4.6 Trudnoća, dojenje i plodnost
English: Please tell your doctor if in the past 2 days you have: - had frequent and/or repeated angina or chest pain, especially if you have history of heart disease, - had recent electrocardiography changes.
Croatian: Obratite se svom liječniku ako ste u protekla 2 dana imali: - čestu i/ili ponavljajuću anginu ili bol u prsnom košu, osobito ako ste imali bolest srca, - nedavne elektrokardiografske promjene.
English: In the second study including 228 patients (463 kidney-ureter units), SonoVue ultrasound was correctly positive in 57 out of 71 units with reflux and correctly negative in 302 out of 392 units without reflux.
Croatian: U drugom ispitivanju koje je uključivalo 228 bolesnika (463 jedinica bubreg-mokraćovod), SonoVue ultrazvuk je bio ispravno pozitivan u 57 od 71 jedinica sa refluksom i ispravno negativan u 302 od 392 jedinica bez refluksa.
English: In one study including 183 patients (366 kidney-ureter units), SonoVue ultrasound was correctly positive in 89 out 103 units with reflux and correctly negative in 226 out of 263 units without reflux.
Croatian: U jednom ispitivanju koje je uključivalo 183 bolesnika (366 jedinica bubregmokraćovod), SonoVue ultrazvuk je bio ispravno pozitivan u 89 od 103 jedinice s refluksom i ispravno negativan u 226 od 263 jedinice bez refluksa.
English: It should be emphasised that stress echocardiography not only can induce an ischaemic episode but also the stressors may induce predictable, dose-dependent effects on the cardiovascular system (e.g., increase in heart rate, blood pressure and ventricular ectopic activity for dobutamine, or decrease in blood pressure for adenosine and dipyridamole) as well as unpredictable, hypersensitivity reactions.
Croatian: Treba naglasiti da stres ehokardiografija može ne samo inducirati ishemijsku epizodu, već stresori mogu inducirati i predvidljive, o dozi ovisne učinke na kardiovaskularni sustav (npr. povećanje srčane frekvencije, krvnog tlaka i ventrikularne ektopičke aktivnosti za dobutamin ili smanjenje krvnog tlaka za adenozin i dipiridamol) kao i nepredvidljive reakcije preosjetljivosti.
English: The recommended doses of SonoVue in adults are:
Croatian: U odraslih, preporučene doze za SonoVue su:
English: Echocardiography
Croatian: Ehokardiografija
English: In particular, please tell your doctor if you are taking beta-blockers (medicines for heart disease and hypertension or for glaucoma in eye drops).
Croatian: Osobito, obavijestite liječnika ako uzimate beta-blokatore (lijekove za srčanu bolest i povišeni krvni tlak ili kapi za oči za glaukom).
English: Chest discomfort, injection site reaction, feeling hot
Croatian: Nelagoda u prsištu, reakcija na mjestu primjene injekcije, osjećaj vrućine
English: The efficacy of SonoVue for detection/exclusion of vesicoureteral reflux was studied in two published open label single centre studies.
Croatian: Djelotvornost lijeka SonoVue za otkrivanje/isključenje vezikoureteralnog refluksa je ispitivana u dva objavljena otvorena monocentrična ispitivanja.
English: It did not reveal any test item-related lesions in any of the examined organs, in particular in the urinary bladder, in both the single-dose and the repeat-dose studies.
Croatian: Nisu otkrivene lezije povezane s bilo kojim testom niti u jednom ispitivanom organu, posebno u mokraćnom mjehuru, u oba ispitivanja, i pojedinačnih doza i ponovljenih doza.
English: In clinical trials, the most commonly reported adverse reactions after intravenous administration are: headache, injection site reaction, and nausea.
Croatian: U kliničkim ispitivanjima, najčešće zabilježene nuspojave nakon intravenske primjene su: glavobolja, reakcija na mjestu injekcije i mučnina.
English: Method of administration For instructions on reconstitution of the medicinal product before administration see section 6.6 .
Croatian: Način primjene Za upute o rekonstituciji lijeka prije primjene vidjeti dio 6.6.
English: SonoVue is an ultrasound contrast agent that contains tiny bubbles filled with a gas called sulphur hexafluoride.
Croatian: SonoVue je ultrazvučno kontrastno sredstvo koje sadrži sitne mjehuriće ispunjene plinom koji se naziva sumporov heksaflourid.
English: Post-authorisation efficacy study (PAES): In order to further evaluate the sensitivity and specificity of SonoVue to detect vesicoureteral reflux through its impact on patient's management, the MAH should conduct and submit the results of a prospective observational cohort study (according to an agreed protocol).
Croatian: Ispitivanje djelotvornosti lijeka nakon davanja odobrenja za stavljanje lijeka u promet (PAES): Kako bi se dodatno procijenila osjetljivost i specifičnost lijeka SonoVue za otkrivanje vezikoureteralnog refluksa kroz njegov učinak u liječenju bolesnika, nositelj odobrenja treba provesti i predati rezultate prospektivnog opservacijskog kohortnog ispitivanja (u skladu s dogovorenim protokolom).
English: If your are an adult SonoVue helps to obtain clearer ultrasound pictures of your heart, your blood vessels and/or tissues of the liver and breast.
Croatian: Ako ste odrasla osoba, SonoVue omogućava dobivanje jasnijih ultrazvučnih snimaka Vašeg srca, Vaših krvnih žila i/ili tkiva jetre i dojki.
English: Uncommon (≥ 1/1,000 to < 1/100)
Croatian: Manje često (≥ 1/1000 do < 1/100)
English: A single-dose study and a repeat-dose study, both followed by a treatment-free period, were performed in female rats with local toxicity evaluated through macroscopic and histopathological examination of both kidneys, ureters, the urinary bladder and urethra.
Croatian: Ispitivanje pojedinačne doze i ponavljanih doza, nakon kojih je slijedilo u oba slučaja razdoblje bez liječenja, provedena su na ženkama štakora kod kojih se lokalna toksičnost procjenjivala putem makroskopskih i histopatoloških pregleda oba bubrega, mokraćovoda, mokraćnog mjehura i mokraćne cijevi.
English: • B-mode imaging of cardiac chambers, at rest or with stress: 2 mL.
Croatian: • Snimanje srčanih komora B-modom, pri mirovanju ili pri stres ehokardiografiji: 2 ml.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT 25 mg powder
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI DOZNOJ JEDINICI LIJEKA 25 mg praška
English: ** In some of the cases of hypersensitivity, in patients with underlying coronary artery disease, myocardial ischemia and/or myocardial infarctions were also reported.
Croatian: ** U nekim slučajevima preosjetljivosti, kod bolesnika s podležećom bolesti koronarnih arterija, zabilježena je i ishemija miokarda i/ili infarkt miokarda.
English: The safety of SonoVue after intravesical administration was based on evaluation of published literature involving use of SonoVue in over 6000 paediatric patients (age range 2 days to 18 years).
Croatian: Sigurnost lijeka SonoVue nakon intravezikalne primjene ocijenjena je na temelju objavljene literature koja obuhvaća primjenu u preko 6000 pedijatrijskih bolesnika (u dobi od 2 dana do 18 godina).
English: Vasovagal reaction
Croatian: Vazovagalna reakcija
English: The undesirable effects reported with SonoVue after intravenous administration were, in general, non-serious, transient and resolved spontaneously without residual effects.
Croatian: Nuspojave zabilježene s lijekom SonoVue nakon intravenske primjene, općenito, nisu bile ozbiljne, bile su prolazne i povlačile su se spontano bez posljedica.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 26 March 2001
Croatian: Datum prvog odobrenja: 26. ožujka 2001.
English: For storage conditions after reconstitution of the medicinal product, see section 6.3.
Croatian: Za uvjete čuvanja nakon rekonstitucije lijeka vidjeti dio 6.3.
English: PHARMACEUTICAL FORM Powder and solvent for dispersion for injection.
Croatian: OBLIK Prašak i otapalo za disperziju za injekciju.
English: SonoVue should only be administered to such patients after careful risk/benefit assessment and a closely monitoring of vital signs should be performed during and after administration.
Croatian: U takvih bolesnika SonoVue se smije primijeniti samo nakon pažljive procjene rizika i koristi, a tijekom i nakon primjene potrebno je pomno praćenje vitalnih znakova.
English: - The active substance is sulphur hexafluoride in the form of microbubbles.
Croatian: - Djelatna tvar je sumporov heksafluorid u obliku mikromjehurića.
English: The total amount of sulphur hexafluoride administered in a clinical dose is extremely small, (in a 2 mL dose the microbubbles contain 16 µl of gas).
Croatian: Ukupna količina sumporovog heksafluorida primijenjenog u kliničkoj dozi je izuzetno mala, (u dozi od 2 ml mikromjehurići sadrže16 µl plina).
English: The filling and emptying of the bladder with saline solution may be repeated if needed.
Croatian: Punjenje i pražnjenje mjehura fiziološkom otopinom se može ponoviti ako je potrebno.
English: It is recommended to keep the patient under close medical supervision during and for at least 30 minutes following the administration of SonoVue.
Croatian: Preporučuje se pažljivo nadzirati bolesnika tijekom i najmanje 30 minuta nakon primjene lijeka SonoVue.
English: SonoVue does not affect the ability to drive and use machines.
Croatian: SonoVue ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: SonoVue is a kit which includes a glass vial containing white powder, a glass syringe containing the solvent and a transfer system.
Croatian: SonoVue je set koji uključuje staklenu bočicu koja sadržava bijeli prašak, staklenu štrcaljku koja sadrži otapalo i sustav za prijenos.
English: The dose recommendations for intravenous administration also apply to elderly patients.
Croatian: Stariji bolesnici Preporučene doze za intravensku primjenu odnose se i na starije bolesnike.
English: Invert the system and carefully withdraw SonoVue into the syringe.
Croatian: Preokrenite sustav i pažljivo uvucite SonoVue u štrcaljku.
English: For ultrasound scan of urinary tract in children the recommended dose is 1 mL per patient to be administered into the bladder as follows:
Croatian: Za ultrazvučno snimanje mokraćnog sustava u djece: preporučena doza je 1 ml po bolesniku za primjenu u mjehur, kako slijedi:
English: At the proposed clinical doses for intravenous administration, SonoVue has been shown to provide marked increase in signal intensity of more than 2 minutes for B-mode imaging in echocardiography and of 3 to 8 minutes for Doppler imaging of the macrovasculature and microvasculature.
Croatian: U preporučenim kliničkim dozama za intravensku primjenu, SonoVue pruža znatan porast u intenzitetu signala za više od 2 minute pri ehokardiografiji u B-modu i za 3 do 8 minuta pri dopplerskom oslikavanju velikih i malih žila.
English: SonoVue should only be used in patients where study without contrast enhancement is inconclusive.
Croatian: SonoVue se smije koristiti samo kod bolesnika kod kojih pretraga bez kontrastnog sredstva ne omogućuje zaključak.
English: Therefore, if SonoVue is to be used in conjunction with stress echocardiography patients must have a stable condition verified by absence of chest pain or ECG modification during the two preceding days.
Croatian: Stoga, ako se SonoVue koristi zajedno sa stres ehokardiografijom, bolesnici moraju tijekom prethodna dva dana biti u stabilnom stanju što se potvrđuje odsutstvom boli u prsištu ili EKG promjena.
English: During a single examination, a second injection of the recommended dose can be made when deemed necessary by the physician.
Croatian: Ako je potrebno, tijekom jednog pregleda liječnik može dati drugu, dodatnu injekciju preporučene doze.
English: * Cases suggestive of hypersensitivity may include: skin erythema, bradycardia, hypotension, dyspnoea, loss of consciousness, cardiac/cardio-respiratory arrest, anaphylactic reaction, anaphylactic shock.
Croatian: * Slučajevi koji upućuju na preosjetljivost mogu uključivati: eritem kože, bradikardiju, hipotenziju, dispneju, gubitak svijesti, kardijalni/kardiorespiratorni arest, anafilaktičku reakciju, anafilaktički šok.
English: SonoVue has no or negligible influence on the ability to drive and use machines.
Croatian: SonoVue ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Rare (≥ 1/10,000 to < 1/1000)
Croatian: Rijetko (≥ 1/10 000 do
English: Each millilitre of SonoVue contains 8 µL of the microbubbles.
Croatian: Svaki mililitar lijeka SonoVue sadrži 8 µl mikromjehurića.
English: Adult population-Intravenous use
Croatian: Odrasla populacija-Intravenska primjena
English: The safety and efficacy of SonoVue in patients under 18 years of age has not been established for intravenous administration and use in echocardiography and vascular Doppler imaging.
Croatian: Sigurnost i djelotvornost lijeka SonoVue kod bolesnika mlađih od 18 godina nisu ustanovljene za intravensku primjenu i primjenu u ehokardiografiji i Doppler prikazu krvnih žila.