FrancophonIA/ELRC3.0 huggingface dataset:
English: Date of latest renewal: 09 January 2017
Croatian: Datum posljednje obnove odobrenja: 9. siječanj 2017.
English: • Infection: if you experience signs of infection caused by bacteria or virus, or other organisms.
Croatian: • Infekcija: ako imate znakove infekcije uzrokovane bakterijama, virusima ili drugim organizmima.
English: Dose adjustment for next cycle/dose (% of starting dose)
Croatian: Prilagodba doze u sljedećem ciklusu/ dozi (% početne doze)
English: The following are the recommended dose modifications for toxicity:
Croatian: Sljedeća tablica pokazuje preporučene prilagodbe doze zbog toksičnosti:
English: • specific changes in the electrocardiogram (QT prolongation)
Croatian: • specifične promjene na elektrokardiogramu (produljenje QT intervala)
English: What Capecitabine Teva is and what it is used for
Croatian: Što je Kapecitabin Teva i za što se koristi
English: See also section “Do not take Capecitabine Teva”.
Croatian: Pogledajte i dio „Nemojte uzimati Kapecitabin Teva“.
English: Hand and foot skin-reaction can lead to loss of fingerprint, which could impact your identification by fingerprint scan.
Croatian: Kožna reakcija na šakama i stopalima može dovesti do gubitka otisaka prstiju, što može utjecati na Vašu identifikaciju skeniranjem otisaka prstiju.
English: intravenous bolus injection immediately after leucovorin
Croatian: intravenska bolus injekcija odmah nakon leukovorina
English: The median time to progression was 93 and 98 days.
Croatian: Medijan vremena do progresije bolesti iznosio je 93 odnosno 98 dana.
English: • If contraindications exist to any of the medicinal products in the combination regimen, that medicinal product should not be used.
Croatian: • Ako postoje kontraindikacije za bilo koji od lijekova koji se primjenjuju u kombinacijskom protokolu, taj se lijek ne smije primjenjivati.
English: • bruising or reaction at the injection site (caused by medicines given by injection at the same time)
Croatian: • modrice ili reakcije na mjestu primjene injekcije (uzrokovane lijekovima koji se istovremeno primjenjuju putem injekcije)
English: -2nd appearance
Croatian: -2. pojavljivanje
English: Severe and/or Life-threatening (grade 3-4) or considered medically relevant
Croatian: Teške i/ili po život opasne (stupanj 3 do 4) ili one koje se smatraju medicinski značajnima
English: Central or peripheral nervous system disease
Croatian: Bolest središnjeg ili perifernog živčanog sustava
English: Other than warfarin, no formal interaction studies between capecitabine and other CYP2C9 substrates have been conducted.
Croatian: Osim s varfarinom, nisu provedena formalna ispitivanja interakcije između kapecitabina i drugih supstrata CYP2C9.
English: For hand-foot syndrome and hyperbilirubinemia, see section 4.4.
Croatian: Za sindrom šaka-stopalo i hiperbilirubinemiju, vidjeti dio 4.4.
English: • unusual bleeding from the vagina
Croatian: • neuobičajeno krvarenje iz rodnice
English: • sleeplessness (insomnia), depression
Croatian: • nesanica (insomnija), depresija
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, ATC code: L01BC06
Croatian: Farmakoterapijska skupina: antineoplastične tvari, antimetaboliti, ATK oznaka: L01BC06
English: • dehydration, weight loss
Croatian: • dehidracija, gubitak težine
English: Your doctor may instruct you to decrease the dose and/or temporarily discontinue treatment with Capecitabine Teva.
Croatian: Liječnik Vam može savjetovati da smanjite dozu i/ili privremeno prestanete uzimati Kapecitabin Teva.
English: Capecitabine Teva may be used either alone or in combination with other medicines.
Croatian: Kapecitabin Teva se može primijeniti samostalno ili u kombinaciji s drugim lijekovima.
English: • ringing or buzzing in the ears (tinnitus), loss of hearing
Croatian: • zvonjenje ili zujanje u ušima (tinitus), gubitak sluha
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 or fluorouracil,
Croatian: • Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 6.1 ili na fluorouracil,
English: Do not take Capecitabine Teva - if you are allergic to capecitabine or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati Kapecitabin Teva: - ako ste alergični na kapecitabin ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: Progression-free Survival after 6 months ITT
Croatian: Preživljenje bez progresije bolesti nakon 6 mjeseci
English: Median overall survival ITT
Croatian: Medijan ukupnog preživljenja
English: (see section 4.4),
Croatian: (vidjeti dio 4.4),
English: These side effects can become severe; therefore, it is important that you always contact your doctor immediately when you start to experience a side effect.
Croatian: Ove nuspojave mogu postati teške, stoga je važno da se obratite svom liječniku odmah čim uočite nuspojave.
English: Capecitabine is activated via several enzymatic steps (see section 5.2).
Croatian: Kapecitabin se aktivira u nekoliko enzimskih koraka (vidjeti dio 5.2.).
English: Only after being absorbed by the body is it changed into an active anti-cancer medicine (more in tumour tissue than in normal tissue).
Croatian: Tek nakon što se apsorbira u organizmu, mijenja se u djelatnu antikarcinogenu tvar (više u tumorskom tkivu nego u zdravom tkivu).
English: HR (97.5% CI)
Croatian: (97,5% CI)
English: • Grade 1
Croatian: • Stupanj 1
English: Contact your doctor immediately if you are concerned about any of the side effects or if you notice any additional side effects not listed in the leaflet (see section 4 Possible side effects).
Croatian: Odmah se obratite svom liječniku ako ste zabrinuti zbog bilo koje nuspojave ili ako primijetite dodatne nuspojave koje nisu navedene u uputi (pogledajte dio 4. Moguće nuspojave).
English: 820 Patients were randomised to receive either sequential treatment (n=410) or combination treatment (n=410).
Croatian: 820 bolesnika randomizirano je u dvije skupine za primanje sekvencijske terapije (n = 410) ili kombinirane terapije (n = 410).
English: The following headings are used to rank the ADRs by frequency: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000).
Croatian: Za klasifikaciju nuspojava prema učestalosti koriste se sljedeće oznake: vrlo često (≥ 1/10), često (≥ 1/100, < 1/10), manje često (≥ 1/1000, < 1/100), rijetko (≥ 1/10 000, < 1/1000) i vrlo rijetko (< 1/10 000).
English: SPECIAL STORAGE CONDITIONS Store below 30 °C.
Croatian: POSEBNE MJERE ČUVANJA Čuvati na temperaturi ispod 30°C.
English: Interactions with allopurinol have been observed for 5-FU; with possible decreased efficacy of 5-FU.
Croatian: Interakcije s alopurinolom primijećene su za 5-FU, s mogućom smanjenom djelotvornošću 5-FU.
English: • blurred or double vision
Croatian: • zamagljen vid ili dvoslike
English: 305, 74770 Opava-Komarov Czech Republic
Croatian: Ostravska 29, c.p. 305, 74770 Opava-Komarov Češka
English: Furthermore, Capecitabine Teva is used to prevent new occurrence of colon cancer after complete removal of the tumour by surgery.
Croatian: Nadalje, Kapecitabin Teva se koristi kako bi se spriječila pojava novog karcinoma kolona nakon što je tumor u potpunosti kirurški uklonjen.
English: • hiccups, change in voice
Croatian: • štucavica, promjene glasa
English: • Chest pain: if you experience pain localised to the centre of the chest, especially if it occurs during exercise.
Croatian: • Bol u prsištu: ako osjetite bol u sredini prsnog koša, osobito ako se pojavi tijekom vježbanja.
English: • eye inflammation causing eye pain and possibly eyesight problems
Croatian: • upala oka koja uzrokuje bol u očima i moguće tegobe s vidom
English: LIST OF EXCIPIENTS Also contains lactose.
Croatian: POPIS POMOĆNIH TVARI Također sadrži laktozu.
English: • History of severe and unexpected reactions to fluoropyrimidine therapy,
Croatian: • Prethodne teške i neočekivane nuspojave na fluoropirimidinsku terapiju,
English: Since metabolism of R-warfarin was not affected, these results indicate that capecitabine down-regulates isozyme 2C9, but has no effect on isozymes 1A2 and 3A4.
Croatian: Budući da nije bilo utjecaja na metabolizam R-varfarina, ovi rezultati pokazuju da kapecitabin smanjuje djelovanje izoenzima 2C9, ali ne utječe na izoenzime 1A2 i 3A4.
English: For terms marked with a “+”, the frequency count was based on grade 3-4 ADRs.
Croatian: Za pojmove označene s „+“, učestalost se temeljila na nuspojavama 3.-4. stupnja.
English: • inflammation of the skin causing red scaly patches due to an immune system illness
Croatian: • upala kože koja uzrokuje crvene ljuskave mrlje, a posljedica je bolesti imunološkog sustava
English: What you need to know before you take Capecitabine Teva
Croatian: Što morate znati prije nego počnete uzimati Kapecitabin Teva
English: Ophthalmologic complications
Croatian: Oftalmološke komplikacije
English: Each pack contains 60 tablets.
Croatian: Svako pakiranje sadrži 60 tableta.
English: Your doctor will prescribe a dose and treatment regimen that is right for you.
Croatian: Liječnik će vam propisati dozu i protokol liječenja koji je najučinkovitiji za Vas.
English: • In patients with known complete absence of dihydropyrimidine dehydrogenase (DPD) activity
Croatian: • Bolesnici s poznatim potpunim nedostatkom aktivnosti dihidropirimidin dehidrogenaze (DPD)
English: • difficulty speaking, impaired memory, loss of movement coordination, balance disorder,
Croatian: • teškoće u govoru, oslabljeno pamćenje, gubitak koordinacije, poremećaj ravnoteže, nesvjestica,
English: • jaundice (yellowing of skin and eyes)
Croatian: • žutica (žuta boja kože i očiju)
English: Although sensitivity analyses show that differences in regimen schedules and timing of tumor assessments impact the ontreatment PFS analysis, a full explanation for this result has not been found.
Croatian: Iako analize osjetljivosti pokazuju da razlike u rasporedu protokola i odabiru vremena za procjenu tumorskog učinka utječu na analizu preživljenja bez progresije bolesti tijekom liječenja, potpuno objašnjenje tog rezultata nije poznato.
English: Capecitabine Teva tablets are usually taken for 14 days followed by a 7 day rest period (when no tablets are taken).
Croatian: Teva se uobičajeno uzima 14 dana, nakon čega slijedi 7 dana pauze (bez uzimanja tableta).
English: The capecitabine pivotal studies included females of childbearing potential and males only if they agreed to use an acceptable method of birth control to avoid pregnancy for the duration of the study and for a reasonable period thereafter.
Croatian: U pivotalna ispitivanja kapecitabina žene reproduktivne dobi i muškarci uključeni su samo ako su pristali koristiti neku prihvatljivu metodu kontrole začeća kako bi izbjegli trudnoću tijekom trajanja ispitivanja i u razumnom razdoblju nakon toga.
English: Patients with renal impairment (see section 4.2, 4.4, and 5.2):
Croatian: Bolesnici s oštećenjem bubrežne funkcije (vidjeti dijelove 4.2, 4.4, i 5.2):
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 20 April 2012
Croatian: Datum prvog odobrenja: 20. travanj 2012.
English: • infections of the lungs or respiratory system (e.g. pneumonia or bronchitis)
Croatian: • infekcija pluća ili dišnog sustava (npr. upala pluća ili bronhitis)
English: Creatinine clearance was found to influence the systemic exposure to 5'-DFUR (35% increase in AUC when creatinine clearance decreases by 50%) and to FBAL (114% increase in AUC when creatinine clearance decreases by 50%).
Croatian: Uočeno je da klirens kreatinina utječe na sistemsku izloženost 5'-DFUR (35%-tno povećanje AUC kad se klirens kreatinina smanji za 50%) i FBAL (114%-tno povećanje AUC kad se klirens kreatinina smanji za 50%).
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency: http://www.ema.europa.eu/.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu/.
English: Each pack contains 120 tablets.
Croatian: Svako pakiranje sadrži 120 tableta.
English: When capecitabine and cisplatin are used in combination, the use of vitamin B6 (pyridoxine) is not advised for symptomatic or secondary prophylactic treatment of hand-foot syndrome, because of published reports that it may decrease the efficacy of cisplatin.
Croatian: Kad se kapecitabin i cisplatin primjenjuju u kombinaciji, ne preporučuje se uzimanje vitamina B6 (piridoksin) za simptomatsko liječenje ili sekundarnu profilaksu sindroma šaka-stopalo jer postoje izvješća da se tako može smanjiti djelotvornost cisplatina.
English: Other side effects are:
Croatian: - Drugi sastojci su:
English: • In patients with severe hepatic impairment,
Croatian: • Bolesnici s teškim oštećenjem jetre,
English: For patients 60 years of age or more, a starting dose reduction of capecitabine to 75% (950 mg/m2 twice daily) is recommended.
Croatian: Bolesnicima starim 60 ili više godina preporučuje se smanjenje početne doze kapecitabina na 75% (950 mg/m2 dvaput dnevno).
English: Method of administration Capecitabine Teva film-coated tablets should be swallowed with water within 30 minutes after a meal.
Croatian: Kapecitabin Teva filmom obložene tablete moraju se progutati s vodom unutar 30 minuta nakon obroka.
English: Careful monitoring of patients ≥60 years of age is advisable.
Croatian: Savjetuje se pažljivo praćenje bolesnika u dobi od ≥ 60 godina.
English: In combination with other medicines the usual dose for adults may be less than 1250 mg/m2 of body surface area, and you may need to take the tablets over a different time period (e.g. every day, with no rest period).
Croatian: U kombinaciji s drugim lijekovima uobičajena doza za odrasle može biti manje od 1250 mg/m2 tjelesne površine, i moguće je da ćete uzimati tablete u drugo vrijeme (npr. svaki dan, bez prekida).
English: • difficulty in urination, blood or protein in the urine
Croatian: • teškoće s mokrenjem, krv ili proteini u mokraći
English: • certain types of arrhythmia (including ventricular fibrillation, torsade de pointes, and bradycardia)
Croatian: • određene vrste aritmije (uključujući fibrilaciju ventrikula, torsade de pointes i bradikardiju)
English: The tablets are available in blisters containing 10 film-coated tablets.
Croatian: Tablete su dostupne u blisterima sa 10 filmom obloženih tableta.
English: ADRs are added according to the highest incidence seen in any of the major combination trials.
Croatian: Nuspojave su svrstane prema najvišoj incidenciji zabilježenoj u bilo kojem od glavnih ispitivanja kombinacijske terapije.
English: Patients with baseline neutrophil counts of <1.5 x 109/L and/or thrombocyte counts of <100 x 109/L should not be treated with capecitabine.
Croatian: Bolesnike s početnim brojem neutrofila <1,5 x 109/L i/ili brojem trombocita <100 x 109/L ne bi trebalo liječiti kapecitabinom.
English: Folinic acid/folic acid
Croatian: Folinatna kiselina/folatna kiselina
English: Posology Recommended posology (see section 5.1):
Croatian: Preporučeno doziranje (vidjeti dio 5.1):
English: The usual dose for adults is 1250 mg/m2 of body surface area taken two times daily (morning and evening).
Croatian: Uobičajena doza za odrasle iznosi 1250 mg/m2 površine tijela i uzima se dvaput dnevno (ujutro i navečer).
English: • Recent or concomitant treatment with brivudine (see section 4.4 and 4.5 for drug-drug interaction),
Croatian: • Nedavno ili istodobno liječenje brivudinom (za informacije o interakciji između lijekova vidjeti dijelove 4.4 i 4.5),
English: Capecitabine has minor or moderate influence on the ability to drive and use machines.
Croatian: Kapecitabin malo ili umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Body temperature increased ** Based on the post-marketing experience, persistent or severe palmar-plantar erythrodysaesthesia syndrome can eventually lead to loss of fingerprints (see section 4.4)
Croatian: **Na temelju iskustva nakon stavljanja lijeka u promet, perzistirajući ili težak sindrom palmarno-plantarne eritrodizestezije može naposljetku dovesti do gubitka otisaka prstiju (vidjeti dio 4.4).
English: Based on the population pharmacokinetic analysis, which included patients with a wide range of ages (27 to 86 years) and included 234 (46%) patients greater or equal to 65, age has no influence on the pharmacokinetics of 5'-DFUR and 5-FU.
Croatian: Na temelju rezultata populacijske farmakokinetske analize, koja je uključivala bolesnike širokoga dobnog raspona (od 27 do 86 godina) te 234 (46%) bolesnika od 65 godina ili starijih, ustanovljeno je da dob nema utjecaja na farmakokinetiku 5'-DFUR i 5-FU.
English: The median follow up at the time of the primary analyses in the intent-to-treat population was 2.1 years; data from analyses following an additional 6 months of follow up are also included in table 9.
Croatian: Medijan praćenja u vrijeme primarnih analiza u populaciji bolesnika predviđenih za liječenje bio je 2,1 godinu; podaci iz analiza nakon dodatnih 6 mjeseci praćenja također su sadržani u tablici 9.
English: Posology adjustments during treatment
Croatian: Prilagodba doziranja tijekom liječenja
English: XELOX or XELOX+ Bevacizumab
Croatian: XELOX + bevacizumab
English: In addition to the above, when capecitabine is used alone, very common side effects which may affect more than 1 in 10 people are: - abdominal pain - rash, dry or itchy skin - tiredness - loss of appetite (anorexia)
Croatian: Uz prethodno navedene, kad se kapecitabin primjenjuje samostalno, vrlo česte nuspojave koje se pojavljuju u više od 1 na 10 osoba su: - bol u trbuhu - osip, suha koža ili svrbež - umor - gubitak apetita (anoreksija)
English: Capecitabine Teva can induce severe skin reactions such as Stevens-Johnson syndrome and Toxic Epidermal Necrolysis.
Croatian: Kapecitabin Teva može potaknuti razvoj teških kožnih reakcija poput Stevens-Johnsonova sindroma i toksične epidermalne nekrolize.
English: Your doctor may want you to take a combination of 150 mg and 500 mg tablets for each dose.
Croatian: Liječnik će možda zahtijevati da za svaku dozu uzimate kombinaciju tableta od 150 mg i 500 mg.
English: This medicine contains less than 1 mmol sodium (23 mg) per film-coated tablet, that is to say essentially “sodium-free”.
Croatian: Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po filmom obloženoj tableti, tj. zanemarive količine natrija.
English: fainting, nerve damage (neuropathy) and problems with sensation
Croatian: oštećenje živaca (neuropatija) i problemi s osjetima
English: • lumps under the skin (lipoma)
Croatian: • kvržice pod kožom (lipom)
English: Diabetes mellitus or electrolyte disturbances
Croatian: Šećerna bolest ili poremećaji elektrolita
English: Table 3 Capecitabine dose reduction schedule (3 weekly cycle or continuous treatment) Toxicity grades* Dose changes within a treatment cycle
Croatian: Tablica 3 Raspored smanjivanja doze kapecitabina (ciklusi od 3 tjedna ili kontinuirano liječenje) Stupanj toksičnosti*
English: Capecitabine Teva belongs to the group of medicines called "cytostatic medicines", which stop the growth of cancer cells.
Croatian: Kapecitabin Teva pripada skupini lijekova pod nazivom "citostatici", koji zaustavljaju rast stanica karcinoma.
English: Altered coagulation parameters and/or bleeding have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon.
Croatian: Promijenjeni koagulacijski parametri i/ili krvarenje zabilježeni su u bolesnika koji su kapecitabin uzimali istodobno s kumarinskim antikoagulansima, kao što su varfarin i fenprokumon.
English: Two examples are provided here: A person whose body weight is 64 kg and height is 1.64 m has a body surface area of 1.7 m2 and should take 4 tablets of 500 mg and 1 tablet of 150 mg two times daily.
Croatian: Ovdje su navedena dva primjera: osoba čija tjelesna težina iznosi 64 kg, a visina 1,64 m ima tjelesnu površinu od 1,7 m2 mora uzimati 4 tablete od 500 mg i 1 tabletu od 150 mg dvaput dnevno.
English: cisplatin, irinotecan), - medicines used to treat folic acid deficiency.
Croatian: cisplatin, irinotekan), - lijekove za liječenje nedostataka folatne kiseline
English: Capecitabine is not indicated in children and adolescents.
Croatian: Kapecitabin nije indiciran za primjenu kod djece i adolescenata.
English: • Diarrhoea: if you have an increase of 4 or more bowel movements compared to your normal bowel movements each day or any diarrhoea at night.
Croatian: • Proljev: ako se pražnjenje crijeva poveća za 4 ili više pražnjenja u usporedbi s normalnim svakodnevnim brojem stolica ili ako imate proljev noću.
English: • severe skin reaction such as skin rash, ulceration and blistering which may involve ulcers of the mouth, nose, genitalia, hands, feet and eyes (red and swollen eyes)
Croatian: • teške kožne reakcije poput osipa kože, vrijedova i mjehurića koji mogu obuhvaćati vrijedove u ustima, nosu, spolnim organima, šakama, stopalima i očima (crvene i otečene oči).
English: This will help reduce the likelihood that the side effect continues or becomes severe.
Croatian: Time će se smanjiti vjerojatnost da se nuspojave produže i razviju u težem obliku.
English: Deficiency of DPD may lead to increased toxicity of capecitabine (see section 4.3 and
Croatian: Pomanjkanje DPD može uzrokovati povećanu toksičnost kapecitabina (vidjeti dijelove 4.3 i 4.4).
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama
English: The enzyme involved in the final conversion to 5-FU, thymidine phosphorylase (ThyPase), is found in tumour tissues, but also in normal tissues, albeit usually at lower levels.
Croatian: Enzim uključen u završnu konverziju u 5-FU, timidin fosforilaza (ThyPase), nađen je u tumorskome tkivu, ali i u zdravim tkivima, iako obično u nižoj razini.
English: If you have taken brivudine you must wait for at least 4 weeks after stoping brivudine before starting to take capecitabine.
Croatian: Ako ste uzimali brivudin, morate pričekati najmanje 4 tjedna od završetka liječenja brivudinom do početka liječenja kapecitabinom.
English: Montagnani et al used the results from the above three studies to provide an overall analysis of randomised studies comparing FOLFIRI and XELIRI treatment regimens in the treatment of mCRC.
Croatian: Montagnani i sur. iskoristili su rezultate triju gore navedenih ispitivanja kako bi proveli sveukupnu analizu randomiziranih ispitivanja u kojima se uspoređivala primjena protokola FOLFIRI i XELIRI u liječenju metastatskog kolorektalnog karcinoma.
English: Parameter: Overall Survival PPP
Croatian: Parametar: ukupno preživljenje
English: According to immunohistochemical studies, thymidine phosphorylase appears to be in large part localised in tumour stromal cells.
Croatian: Prema imunohistokemijskim istraživanjima, izgleda da je timidin fosforilaza većinom lokalizirana u tumorskim stromalnim stanicama.
English: Elderly During capecitabine monotherapy, no adjustment of the starting dose is needed.
Croatian: U monoterapiji kapecitabinom nije potrebna prilagodba početne doze.
English: Cardiotoxicity has been associated with fluoropyrimidine therapy, including myocardial infarction, angina, dysrhythmias, cardiogenic shock, sudden death and electrocardiographic changes (including very rare cases of QT prolongation).
Croatian: Kardiotoksičnost se povezuje s fluoropirimidinskom terapijom i uključuje infarkt miokarda, anginu, disritmije, kardiogeni šok, iznenadnu smrt i elektrokardiografske promjene (uključujući vrlo rijetke slučajeve produljenja QT intervala).