FrancophonIA/ELRC3.0 huggingface dataset:
English: At Week 2, the mean viral load decrease was 0.87 log10 copies/mL in Arm A, 1.15 log10 copies/mL in Arm B and 0.38 log10 copies/mL in the Placebo arm (p=0.003 vs Arm A, p<0.001 vs Arm B).
Slovenian: 1,15 log10 kopij/ml v skupini B in 0,38 log10 kopij/ml v skupini s placebom (p = 0,003 proti skupini A, p < 0,001 proti skupini B).
English: A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Slovenian: PROIZVAJALEC ODGOVOREN ZA SPROŠČANJE SERIJ
English: Recommended ibalizumab dose and number of vials per administration
Slovenian: Priporočeni odmerek ibalizumaba in število vial na dajanje
English: No. of subjects achieving <200 HIV-1 RNA copies/mL (n/N)
Slovenian: Št. preiskovancev, ki dosegajo < 200 kopij/ml (n/N) HIV-1 RNK
English: No. of subjects achieving <50 HIV-1 RNA copies/mL (n/N)
Slovenian: Št. preiskovancev, ki dosegajo < 50 kopij/ml (n/N) HIV-1 RNK
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1. 4.4 Posebna opozorila in previdnostni ukrepi Sledljivost
English: Trogarzo 200 mg concentrate for solution for infusion ibalizumab
Slovenian: Trogarzo 200 mg koncentrat za raztopino za infundiranje ibalizumab
English: What Trogarzo is used for
Slovenian: Za kaj uporabljamo zdravilo Trogarzo
English: What Trogarzo is and what it is used for
Slovenian: Kaj je zdravilo Trogarzo in za kaj ga uporabljamo Kaj je zdravilo Trogarzo
English: Laboratory abnormalities
Slovenian: Nenormalni rezultati laboratorijskih testov
English: Hepatic impairment
Slovenian: • nenormalen srčni utrip
English: How to store Trogarzo
Slovenian: Kako prejeti zdravilo Trogarzo
English: • dry mouth
Slovenian: • suha koža
English: Headache, feeling dizzy, feeling sick (nausea) or feeling tired are common side effects of Trogarzo and can affect your ability to drive or use machines.
Slovenian: Glavobol, omotičnost, siljenje na bruhanje (navzea) ali utrujenost so pogosti neželeni učinki zdravila
English: Ibalizumab is administered intravenously (IV), after diluting the appropriate number of vials in 250 mL of sodium chloride 9 mg/mL (0.9%) solution for injection.
Slovenian: ), potem ko razredčimo ustrezno število vial v 250 ml raztopine natrijevega klorida 9 mg/ml (0,9 %) za injiciranje.
English: Sodium chloride Polysorbate 80
Slovenian: saharoza natrijev klorid polisorbat 80 histidin klorovodikova kislina voda za injekcije
English: Trogarzo 200 mg concentrate for solution for infusion
Slovenian: IME ZDRAVILA Trogarzo 200 mg koncentrat za raztopino za infundiranje
English: Talk to your doctor or nurse about how to avoid infecting other people.
Slovenian: O tem, kako preprečiti okužbo drugih ljudi, se posvetujte se z zdravnikom ali medicinsko sestro.
English: No formal studies were conducted to examine the effects of renal impairment on the pharmacokinetics of ibalizumab.
Slovenian: Formalnih študij za preučitev učinkov ledvične okvare na farmakokinetiko ibalizumaba niso izvedli.
English: • Insert sterile syringe needle into the vial through the center of the stopper and withdraw 1.33 mL from each vial (NOTE: a small residual amount may remain in the vial, discard unused portion) and transfer into a 250 mL intravenous bag of sodium chloride 9 mg/mL (0.9%) solution for injection.
Slovenian: (OPOMBA: v viali lahko ostane majhna količina preostanka, zavrzite neporabljeni del) ter to prenesite v 250-ml vrečko z raztopino natrijevega klorida 9 mg/ml (0,9 %) za injiciranje.
English: Resume maintenance dosing (800 mg) every 2 weeks thereafter.
Slovenian: Po 2 tednih je treba nadaljevati zdravljenje z vzdrževalnim odmerkom (800 mg).
English: • tremor
Slovenian: • tresenje
English: outcomes are shown in Table 3.
Slovenian: 25. tedna so prikazani v preglednici 3.
English: Serious side effects Talk to your doctor or nurse straight away if you get any of the following serious side effects: Signs of a new infection, changes in your immune system, can happen when you start using HIV medicines.
Slovenian: • Ko začnete uporabljati zdravila za zdravljenje okužbe z virusom HIV, se lahko pojavijo znaki nove okužbe in spremembe v vašem imunskem sistemu.
English: It belongs to a group of medicines called ‘antiretrovirals'.
Slovenian: Spada v skupino zdravil, imenovanih
English: The median time to maximum serum concentration (Tmax) of 2,000 mg and 800 mg is 1 hr and 10 min, respectively.
Slovenian: 2.000 mg je 1 ura, do koncentracije 800 mg pa 10 minut.
English: No formal studies were conducted to examine the effects of hepatic impairment on the pharmacokinetics of ibalizumab.
Slovenian: Formalnih študij za preučitev učinkov jetrne okvare na farmakokinetiko ibalizumaba niso izvedli.
English: Trogarzo contains the active substance ibalizumab.
Slovenian: Zdravilo Trogarzo vsebuje učinkovino ibalizumab.
English: Hepatic impairment is not anticipated to impact the pharmacokinetics of ibalizumab.
Slovenian: Ne pričakuje se, da bi okvara ledvic vplivala na farmakokinetiko ibalizumaba.
English: • diarrhoea feeling sick (nausea) or being sick (vomiting) dizziness headache feeling tired dry skin dermatitis - a type of eczema with dry itchy skin pain and feeling numb in hands, feet or legs
Slovenian: • dermatitis - vrsta ekcema s suho srbečo kožo
English: There is no known antidote to ibalizumab overdose.
Slovenian: 4.9 Preveliko odmerjanje Ni znanega antidota za preveliko odmerjanje ibalizumaba.
English: Immune system disorders hypersensitivity, immune reconstitution inflammatory syndrome (see below and section 4.4)
Slovenian: bolezni imunskega sistema preobčutljivost, vnetni sindrom imunske obnove
English: Diluted solution
Slovenian: Razredčena raztopina
English: Subjects all received OBR plus 1 of the following regimens: alternating intravenous (IV) infusions of 15 mg/kg ibalizumab and placebo, weekly for the first 9 doses (through the Week 8 visit), then IV infusions of 15 mg/kg ibalizumab every 2 weeks (Arm A); 10 mg/kg ibalizumab IV infusions weekly for the first 9 doses (through the Week 8 visit), then IV infusions of 10 mg/kg ibalizumab every 2 weeks (Arm B); or weekly placebo IV infusions for the first 9 doses (through the Week 8 visit), then IV infusions of placebo every 2 weeks (Placebo arm).
Slovenian: infuzije 15 mg/kg ibalizumaba in placeba enkrat tedensko prvih 9 odmerkov (do obiska v 8. tednu), nato i.v.
English: 2 vials
Slovenian: OVOJNINAH VIALA
English: NAME OF THE MEDICINAL PRODUCT Trogarzo 200 mg concentrate for solution for infusion ibalizumab
Slovenian: Navodilo za uporabo Trogarzo 200 mg koncentrat za raztopino za infundiranje ibalizumab
English: What you need to know before you use Trogarzo
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Trogarzo Zdravila Trogarzo ne smete prejeti:
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each vial contains 200 mg of ibalizumab
Slovenian: Ena viala vsebuje 200 mg ibalizumaba.
English: 2 log10 reduction in viral load at Week 25.
Slovenian: preiskovancev pa za ≥ 2 log10.
English: Ibalizumab is administered as an IV infusion.
Slovenian: Ibalizumab se daje v obliki intravenske infuzije.
English: Uncommon
Slovenian: • omotica
English: How much Trogarzo you will be given The recommended dose of Trogarzo is: a single dose of 2,000 mg on the first occasion followed by a maintenance dose of 800 mg every 2 weeks.
Slovenian: • enkratni odmerek 2.000 mg ob prvi uporabi, • ki mu sledi vzdrževalni odmerek 800 mg vsaka 2 tedna
English: CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription.
Slovenian: POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE Predpisovanje in izdaja zdravila je le na recept s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
English: decrease in viral load N=40
Slovenian: N = 40
English: This medicinal product should be inspected visually for particulate matter and discoloration prior to administration.
Slovenian: Previdnostni ukrepi, potrebni pred ravnanjem z zdravilom ali dajanjem zdravila Pred uporabo je treba to zdravilo vizualno pregledati, da ne vsebuje trdih delcev in ni spremenjene barve.
English: Adverse reaction frequency*
Slovenian: Pogostost*
English: The valid summary of product characteristics, labelling and package leaflet are the final versions achieved during the Coordination group procedure.
Slovenian: Zadnji veljavni Povzetek glavnih značilnosti zdravila, označevanje in Navodilo za uporabo so končne verzije dosežene v postopku koordinacijske skupine.
English: Summary of product characteristics, labelling and package leaflet
Slovenian: Povzetek glavnih začilnosti zdravila, označevanje in navodilo za uporabo
English: 84 vials + 88 ampoules
Slovenian: 84 vial + 88 ampul
English: 84 vials + 88 ampoules + 1 Altera Nebuliser Handset
Slovenian: 84 vial + 88 ampul + 1 komplet z nebulatorjem Altera
English: These changes do not have any clinical significance.
Slovenian: Te spremembe nimajo bistvenega kliničnega pomena.
English: Date of first authorisation: 19 June 2015
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum prve odobritve: 19. junij 2015
English: Therefore, there is no evidence of efficacy in this paediatric patient population.
Slovenian: Zato v tej populaciji pediatričnih bolnikov ni dokazov za učinkovitost.
English: Falls were more common in the elderly (≥65 years old).
Slovenian: Padci so bili bolj pogostejši pri starejših (≥ 65 let).
English: • depression
Slovenian: • depresije
English: • tinnitus (hearing sound in the ear when there is no external sound)
Slovenian: • tinitus (zvenjenje v ušesih, kljub temu da ni zunanjega zvoka)
English: Talk to your doctor if you do not feel better after 2 months.
Slovenian: Posvetujte se z zdravnikom, če se vaše počutje po dveh mesecih ne izboljša.
English: Use within 6 months after opening.
Slovenian: Po odprtju porabiti v 6 mesecih.
English: The safety results from this study were consistent with the known safety profile of duloxetine.
Slovenian: Rezultati varnosti iz te študije so bili skladni z znanim varnostnim profilom duloksetina.
English: • fast and/or irregular heart beat
Slovenian: • hitro in/ali nepravilno bitje srca
English: You may be more likely to think like this if you: - have previously had thoughts about killing or harming yourself - are a young adult.
Slovenian: Pojav takšnih misli je verjetnejši, če: - ste že kdaj razmišljali o samomoru ali samopoškodovanju - ste mlajša odrasla oseba.
English: Opening date:…………
Slovenian: Datum odprtja:
English: Frequency estimate: Very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000).
Slovenian: Ocene pogostnosti: zelo pogosti ( 1/10), pogosti ( 1/100 do  1/10), občasni ( 1/1.000 do  1/100), redki ( 1/10.000 do < 1/1.000), zelo redki (< 1/10.000).
English: There have been reports of long-lasting sexual dysfunction where the symptoms have continued despite discontinuation of SSRIs/SNRIs.
Slovenian: Poročali so o dolgotrajni spolni disfunkciji, pri kateri so se simptomi nadaljevali kljub prekinitvi zdravljenja s SSRI/SNRI.
English: 3752 LB Bunschoten The Netherlands
Slovenian: 3752 LB Bunschoten Nizozemska
English: In some cases, these symptoms have continued after stopping treatment.
Slovenian: V nekaterih primerih so se simptomi nadaljevali tudi po prekinitvi zdravljenja.
English: Food delays the time to reach the peak concentration from 6 to 10 hours and it marginally decreases the extent of absorption (approximately 11%).
Slovenian: Hrana podaljša čas, potreben za doseganje najvišje koncentracije, s 6 na 10 ur in mejno zmanjša obseg absorpcije (približno 11 %).
English: Children and adolescents under 18 years of age with depression treated with this medicine had some weight loss when they first start taking this medicine.
Slovenian: Pri otrocih in mladostnikih, mlajših od 18 let, ki so se za depresijo zdravili s tem zdravilom, so ugotovili nekaj izgube telesne mase na začetku jemanja tega zdravila.
English: Women should be advised to notify their physician if they become pregnant, or intend to become pregnant, during therapy.
Slovenian: Ženskam je treba svetovati, naj obvestijo svojega zdravnika, če med zdravljenjem zanosijo ali načrtujejo nosečnost.
English: • headache, feeling sleepy
Slovenian: • glavobol, občutek zaspanosti
English: • menopausal symptoms, abnormal production of breast milk in men or women
Slovenian: • menopavzni simptomi, nenormalna tvorba mleka v dojkah pri moških ali ženskah
English: Some patients who stop taking Duloxetine Mylan suddenly have had symptoms such as:
Slovenian: Nekateri bolniki, ki so nenadoma prenehali jemati zdravilo Duloksetin Mylan, so imeli simptome, kot so:
English: Your doctor or midwife should be aware that you are taking duloxetine so they can advise you.
Slovenian: Zdravnik ali babica morata vedeti, da jemljete duloksetin, tako da vam bosta lahko svetovala.
English: These medicines increase the risk of side effects; if you get any unusual symptom taking any of these medicines together with Duloxetine Mylan, you should see your doctor.
Slovenian: Ta zdravila povečajo tveganje za neželene učinke; če se pojavi kakršenkoli neobičajen simptom ob jemanju katerega od teh zdravil skupaj z zdravilom Duloksetin Mylan, obiščite zdravnika.
English: No studies on the effects on the ability to drive and use machines have been performed.
Slovenian: Študij vpliva na sposobnost vožnje in upravljanja strojev niso izvedli.
English: Epidemiological data have suggested that the use of SSRIs in pregnancy, particularly in late pregnancy, may increase the risk of persistent pulmonary hypertension in the newborn (PPHN).
Slovenian: Epidemiološki podatki kažejo, da uporaba SSRI v nosečnosti, še posebej v pozni nosečnosti, lahko povečala tveganje za primarno pljučno hipertenzijo pri novorojenčkih (PPHN).
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkanjem saharaze-izomaltaze ne smejo jemati tega zdravila.
English: • excessive vaginal bleeding shortly after birth (postpartum haemorrhage)
Slovenian: • prekomerna krvavitev iz nožnice kmalu po porodu (poporodna krvavitev)
English: Do not start or stop taking any medicines, including those bought without a prescription and herbal remedies, before checking with your doctor.
Slovenian: Ne začnite jemati niti ne prenehajte jemati katerih koli zdravil, vključno s tistimi, ki ste jih kupili brez recepta, in zdravil rastlinskega izvora, ne da bi se pred tem posvetovali z zdravnikom.
English: Age: Pharmacokinetic differences have been identified between younger and elderly females (≥65 years) (AUC increases by about 25% and half-life is about 25% longer in the elderly), although the magnitude of these changes is not sufficient to justify adjustments to the dose.
Slovenian: Ugotavljali so farmakokinetične razlike med mlajšimi in starejšimi ženskami ( 65 let) (pri starejših bolnikih se AUC poviša za približno 25 %, razpolovni čas pa je daljši za približno 25 %), vendar obseg teh sprememb ni tolikšen, da bi upravičil prilagajanje odmerka.
English: The dose may be adjusted up to 120 mg a day based on your response to Duloxetine Mylan.
Slovenian: Odmerek bo morda prilagojen do 120 mg na dan, glede na vaš odziv na zdravilo Duloksetin Mylan.
English: Very rare side effects (may affect up to 1 in 10,000 people) • inflammation of the blood vessels in the skin (cutaneous vasculitis)
Slovenian: Zelo redki neželeni učinki (se lahko pojavijo pri največ 1 od 10.000 bolnikov) • vnetje krvnih žil v koži (kožni vaskulitis)
English: If your doctor has prescribed Duloxetine Mylan for a patient under 18 and you want to discuss this, please go back to your doctor.
Slovenian: Če je zdravnik predpisal zdravilo Duloksetin Mylan bolniku, mlajšemu od 18 let, in se želite o tem pogovoriti, se, prosimo, obrnite na zdravnika.
English: • serious allergic reaction which causes difficulty in breathing or dizziness with swollen tongue or lips, allergic reactions
Slovenian: • resne alergijske reakcije, ki povzročajo težave z dihanjem ali omotico z oteklostjo jezika ali ustnic, alergijske reakcije
English: Specific in vivo drug interaction studies have not been performed.
Slovenian: Specifičnih študij medsebojnega delovanja zdravil in vivo niso izvedli.
English: Other psychiatric conditions for which Duloxetine Mylan is prescribed can also be associated with an increased risk of suicide-related events.
Slovenian: Druga psihiatrična stanja, za katera predpisujemo zdravilo Duloksetin Mylan so tudi lahko povezana z večjim tveganjem za pojav dogodkov povezanih s samomorom.
English: c. Description of selected adverse reactions
Slovenian: c. Opis izbranih neželenih učinkov
English: A conclusion on the overall benefit/risk in this age group has not been established (see also sections 4.2 and 4.8).
Slovenian: Zaključek glede splošnih koristi/tveganj pri tej starostni skupini ni bil podan (glejte tudi poglavji 4.2 in
English: Dose escalation should be based upon clinical response and tolerability.
Slovenian: Zvišanje odmerka mora biti osnovano na kliničnem odgovoru in prenašanju zdravila.
English: Observational data have provided evidence of an increased risk (less than 2-fold) of postpartum haemorrhage following duloxetine exposure within the month prior to birth.
Slovenian: Podatki iz opazovanj dokazujejo povečano tveganje (manj kot 2-krat večje) za poporodne krvavitve po izpostavljenosti duloksetinu znotraj enega meseca pred porodom.
English: Cases of orthostatic hypotension and syncope have been reported especially at the initiation of treatment.
Slovenian: O primerih ortostatske hipotenzije in sinkope so poročali zlasti ob začetku zdravljenja.
English: Only a small proportion of patients included in pivotal clinical trials had severe depression (baseline HAM-D>25).
Slovenian: Le majhen delež bolnikov, sodelujočih v presečnih kliničnih preskušanjih, je imel hudo depresijo (izhodiščno število točk po HAM-D  25).
English: CNS medicinal products: The risk of using duloxetine in combination with other CNS-active medicinal products has not been systematically evaluated, except in the cases described in this section.
Slovenian: Tveganja uporabe duloksetina v kombinaciji z drugimi zdravili, ki delujejo na CŽS, niso sistematično vrednotili, razen v primerih, opisanih v tem poglavju.
English: The primary outcome measure was the weekly mean of 24-hour average pain, which was collected in a daily diary by patients on an 11-point Likert scale.
Slovenian: Primarna mera izida je bilo tedensko povprečje 24-urne povprečne bolečine, kar smo zbrali iz dnevnih dnevnikov bolnikov na podlagi 11-točkovne Likertove lestvice.
English: Estimated frequency based on all clinical trial data.
Slovenian: Ocenjena pogostnost temelji na vseh podatkih kliničnih preskušanj.
English: Taking a MAOI together with many prescription medicines, including Duloxetine Mylan, can cause serious or even life-threatening side effects.
Slovenian: Jemanje MAOI skupaj z mnogimi zdravili na recept, vključno z zdravilom Duloksetin Mylan, lahko povzroči resne ali celo smrtno nevarne neželene učinke.
English: Duloxetine Mylan should be used in pregnancy only if the potential benefit justifies the potential risk to the foetus.
Slovenian: Zdravilo Duloksetin Mylan naj se v nosečnosti uporablja le, če možna korist upravičuje možno tveganje za plod.
English: • Duloxetine Mylan may cause effects that you may not be aware of, such as increases in liver enzymes or blood levels of potassium, creatine phosphokinase, sugar, or cholesterol
Slovenian: • Duloksetin Mylan lahko povzroči neželene učinke, ki se jih morda ne zavedate, kot so povišanje vrednosti jetrnih encimov ali vrednosti kalija, kreatin fosfokinaze, sladkorja ali holesterola v krvi.
English: Pharmacotherapeutic group: Other antidepressants.
Slovenian: Farmakoterapevtska skupina: Drugi antidepresivi.
English: Cases of aggression and anger have been reported particularly early in treatment or after treatment discontinuation.
Slovenian: O primerih agresije in jeze so poročali zlasti ob začetku zdravljenja in po prekinitvi zdravljenja.
English: Do not drive or use any tools or machines until you know how Duloxetine Mylan affects you.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Ne vozite in ne upravljajte z orodji ali stroji, dokler ne veste, kako zdravilo Duloksetin Mylan vpliva na vas.
English: Do not stop taking Duloxetine Mylan, or change your dose, without talking to your doctor.
Slovenian: Ne prenehajte jemati zdravila Duloksetin Mylan in ne spreminjajte odmerka, ne da bi se posvetovali z zdravnikom.
English: Cases of convulsion and cases of tinnitus have also been reported after treatment discontinuation.
Slovenian: O primerih konvulzij in o primerih tinitusa so poročali tudi po prekinitvi zdravljenja.
English: During the 10-week acute treatment period, suicidal behaviours were reported (duloxetine 0/333 [0%], fluoxetine 2/225 [0.9%], placebo 1/220 [0.5%]).
Slovenian: Med 10-tedenskim obdobjem akutnega zdravljenja so poročali o samomorilnem vedenju (duloksetin 0/333 [0 %], fluoksetin 2/225 [0,9%], placebo 1/220 [0,5 %]).
English: It weakly inhibits dopamine reuptake with no significant affinity for histaminergic, dopaminergic, cholinergic and adrenergic receptors.
Slovenian: Šibko zavira privzem dopamina brez pomembne afinitete za histaminergične, dopaminergične, holinergične in adrenergične receptorje.
English: You should use Duloxetine Mylan only after discussing the potential benefits and any potential risks to your unborn child with your doctor.
Slovenian: Zdravilo Duloksetin Mylan lahko uporabljate le po tem, ko ste se o možnih koristih in morebitnih možnih tveganjih za vašega nerojenega otroka pogovorili z zdravnikom.
English: However, as with any medicine, caution should be exercised when treating the elderly, especially with Duloxetine Mylan 120 mg per day for major depressive disorder or generalised anxiety disorder, for which data are limited (see sections 4.4 and 5.2).
Slovenian: Vendar pa je, kot pri vseh zdravilih, pri zdravljenju starejših potrebna previdnost, posebno z zdravilom Duloksetin Mylan 120 mg na dan za zdravljenje velike depresivne motnje ali generalizirane anksiozne motnje, za kar je na voljo malo podatkov (glejte poglavji 4.4 in 5.2).
English: Despite this, your doctor may prescribe Duloxetine Mylan for patients under 18 because he/she decides that this is in their best interests.
Slovenian: Temu navkljub lahko zdravnik predpiše zdravilo Duloksetin Mylan tudi bolnikom, mlajšim od 18 let, če se odloči, da je to v njihovo najboljšo korist.
English: Data on the use of duloxetine 120 mg in elderly patients with major depressive disorder and generalised anxiety disorder are limited.
Slovenian: Podatkov o uporabi duloksetina 120 mg pri starejših bolnikih z veliko depresivno motnjo in generalizirano anksiozno motnjo je malo.
English: Hyponatraemia may be due to a syndrome of inappropriate anti-diuretic hormone secretion (SIADH).
Slovenian: Hiponatriemija je lahko posledica sindroma neustreznega izločanja antidiuretičnega hormona (SIADH).
English: • suicidal behaviour, mania (over activity, racing thoughts and decreased need for sleep), hallucinations, aggression and anger
Slovenian: • samomorilno vedenje, manija (prevelika aktivnost, begajoče misli in zmanjšana potreba po spanju), halucinacije, agresivnost in jeza
English: Both cytochromes P450-2D6 and 1A2 catalyse the formation of the two major metabolites glucuronide conjugate of 4-hydroxy duloxetine and sulfate conjugate of 5-hydroxy 6-methoxy duloxetine.
Slovenian: Oba citokroma, P450-2D6 in 1A2, katalizirata tvorbo dveh poglavitnih presnovkov glukuronidnega konjugata 4-hidroksi duloksetina in sulfatnega konjugata 5-hidroksi 6-metoksi duloksetina.