FrancophonIA/ELRC3.0 huggingface dataset:
English: The most common severe reactions (which may affect 1 or more people in 20) are abnormal liver tests, tiredness, diarrhoea, nausea, vomiting and hyperglycaemia (high blood sugar).
Croatian: Najčešće ozbiljne reakcije (koje se mogu javiti u 1 ili više osoba na 20) jesu abnormalni jetreni testovi, umor, proljev, mučnina, povraćanje i hiperglikemija (visoka razina šećera u krvi).
English: ALK belongs to a family of proteins called receptor tyrosine kinases, which are involved in the growth of cells and the development of new blood vessels that supply them.
Croatian: ALK pripada obitelji proteina naziva receptorske tirozin kinaze, koje su uključene u rast stanica i razvoj novih krvnih žila koje ih opskrbljuju.
English: Zykadia received a conditional marketing authorisation valid throughout the EU on 06 May 2015.
Croatian: Lijek Zykadia je dobio uvjetno odobrenje za stavljanje lijeka u promet koje je na snazi u Europskoj uniji od 6. svibnja 2015.
English: Zykadia can only be obtained with a prescription and treatment must be started and supervised by a doctor who is experienced in using cancer medicines.
Croatian: Zykadia se izdaje samo na liječnički recept, a liječenje mora započeti i nadzirati liječnik koji ima iskustva s primjenom lijekova protiv raka.
English: What are the risks associated with Zykadia?
Croatian: Koji su rizici povezani s lijekom Zykadia?
English: In one study 56% of patients given Zykadia (92 of 163) were considered by the treating doctors to have shown a complete or partial response to the medicine.
Croatian: U jednom ispitivanju ordinirajući liječnici zaključili su da je u 56 % bolesnika koji su primali lijek Zykadia (92 od 163) postignut potpun ili djelomičan odgovor na lijek.
English: Why is Zykadia authorised in the EU?
Croatian: Zašto je lijek Zykadia odobren u EU-u?
English: It is only used if the NSCLC is ‘ALKpositive', which means that the cancer cells have certain defects affecting the gene responsible for a protein called ALK (anaplastic lymphoma kinase).
Croatian: Koristi se samo ako je NSCLC pozitivan na ALK, što znači da stanice raka imaju određene nedostatke koji utječu na gen odgovoran za protein naziva kinaza anaplastičnog limfoma (engl. anaplastic lymphoma kinase, ALK).
English: Side effects reported with Zykadia are carefully evaluated and any necessary action taken to protect patients.
Croatian: Nuspojave prijavljene za lijek Zykadia pažljivo se procjenjuju i poduzimaju se potrebne mjere za zaštitu bolesnika.
English: Zykadia contains the active substance ceritinib.
Croatian: Zykadia sadrži djelatnu tvar ceritinib.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Zykadia have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Zykadia nalaze se u sažetku opisa svojstava lijeka i u uputi o lijeku.
English: How does Zykadia work?
Croatian: Kako djeluje Zykadia?
English: As for all medicines, data on the use of Zykadia are continuously monitored.
Croatian: Kao za sve lijekove, podatci o primjeni lijeka Zykadia kontinuirano se prate.
English: An overview of Zykadia and why it is authorised in the EU
Croatian: Pregled informacija o lijeku Zykadia i zašto je odobren u EU-u
English: Zykadia is a cancer medicine used on its own to treat adults with a type of lung cancer called nonsmall-cell lung cancer (NSCLC), when the disease is advanced.
Croatian: Zykadia je lijek protiv raka koji se koristi za liječenje odraslih osoba s rakom pluća koji se naziva rak pluća nemalih stanica (NSCLC), u slučaju uznapredovale bolesti.
English: Results showed that patients given Zykadia lived for an average of 5.4 months without their disease getting worse (progression-free survival) compared with 1.6 months in patients given standard chemotherapy.
Croatian: Rezultati su pokazali da su bolesnici koji su primali lijek Zykadia živjeli prosječno 5,4 mjeseca bez pogoršanja bolesti (preživljenje bez progresije bolesti), u usporedbi s 1,6 mjeseci u bolesnika koji su primali uobičajenu kemoterapiju.
English: For more information about using Zykadia, see the package leaflet or contact a doctor or pharmacist.
Croatian: Više informacija o primjeni lijeka Zykadia pročitajte u uputi o lijeku, odnosno obratite se liječniku ili ljekarniku.
English: In the third study in 231 patients, Zykadia was compared with standard chemotherapy (medicines to treat cancer).
Croatian: U trećem ispitivanju lijek Zykadia uspoređen je s uobičajenom kemoterapijom (lijekovima protiv raka) u 231 bolesnika.
English: The doctor may decide to reduce the dose or stop treatment temporarily if side effects occur.
Croatian: Ako se razviju određene nuspojave, liječnik može odlučiti smanjiti dozu ili privremeno prekinuti liječenje.
English: Zykadia has been shown to be effective at treating patients whose disease progressed during or shortly after treatment with crizotinib and who currently have very limited treatment options, as well as patients who have not been treated before.
Croatian: Dokazana je učinkovitost lijeka Zykadia u liječenju bolesnika u kojih je bolest napredovala tijekom ili ubrzo nakon terapije krizotinibom koji trenutačno imaju vrlo ograničene mogućnosti liječenja te u bolesnika koji prethodno nisu liječeni.
English: In patients with ALK-positive NSCLC, an abnormal form of ALK is produced that stimulates the cancer cells to divide and grow in an uncontrolled fashion.
Croatian: U bolesnika s NSCLC-om pozitivnim na ALK stvara se abnormalni oblik ALK-a koji stimulira dijeljenje i nekontrolirani rast stanica raka.
English: The active substance in Zykadia, ceritinib, works by blocking the activity of ALK, thereby reducing the growth and spread of the cancer.
Croatian: Djelatna tvar lijeka Zykadia, ceritinib, inhibira djelovanje ALK-a te tako smanjuje rast i širenje raka.
English: Patients given Zykadia lived for an average of 16.6 months without their disease getting worse compared with 8.1 months in patients given standard chemotherapy.
Croatian: Bolesnici koji su primali lijek Zykadia živjeli su u prosjeku 16,6 mjeseci bez pogoršanja bolesti, a oni koji su primali uobičajenu kemoterapiju 8,1 mjesec.
English: Zykadia has been shown to be effective at treating advanced, ALK-positive NSCLC in three main studies in patients whose disease progressed despite previous treatment with the medicine crizotinib:
Croatian: Djelotvornost lijeka Zykadia u liječenju uznapredovalog NSCLC-a pozitivnog na ALK dokazana je u trima glavnim ispitivanjima kojima su bili obuhvaćeni bolesnici čija je bolest napredovala unatoč prethodnom liječenju krizotinibom.
English: Regarding safety, the adverse effects with Zykadia generally appeared manageable.
Croatian: S obzirom na sigurnost primjene, čini se da je nuspojave lijeka Zykadia uglavnom moguće kontrolirati.
English: What benefits of Zykadia have been shown in studies?
Croatian: Koje su koristi lijeka Zykadia utvrđene u ispitivanjima?
English: For the full list of side effects and restrictions with Zykadia, see the package leaflet.
Croatian: Potpuni popis svih nuspojava i ograničenja pri primjeni lijeka Zykadia potražite u uputi o lijeku.
English: Zykadia has also been shown to be effective at treating patients who had not been treated before in a study in 376 patients.
Croatian: Ispitivanjem koje je provedeno među 376 bolesnika dokazana je i učinkovitost lijeka Zykadia u liječenju bolesnika koji prethodno nisu liječeni.
English: Sevohale1 (sevoflurane)
Croatian: Sevohale1 (sevofluran)
English: Together, these combined actions result in loss of consciousness.
Croatian: Kombinacija tih djelovanja rezultira gubitkom svijesti.
English: 1 Previously known as Sevocalm
Croatian: 1 Prethodno poznat kao Sevocalm
English: Further information on Sevohale can be found on the Agency's website: ema.europa.eu/Find medicine/Veterinary medicines/European public assessment reports.
Croatian: Više informacija o VMP-u Sevohale nalazi se na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Veterinary medicines/European public assessment reports.
English: What is Sevohale and what is it used for?
Croatian: Što je Sevohale i za što se koristi?
English: The name of the medicine was changed to Sevohale on 29 July 2016.
Croatian: Naziv VMP-a promijenjen je u Sevohale 29. srpnja 2016.
English: Sevohale is given using specialised anaesthetic equipment, usually in a carefully controlled mixture including oxygen.
Croatian: Sevohale se primjenjuje s pomoću specijalizirane opreme za anesteziju, obično u pažljivo kontroliranoj smjesi koja sadrži kisik.
English: What are the benefits and risks of Sevohale?
Croatian: Koje su koristi i rizici od VMP-a Sevohale?
English: Sevohale is used to bring about and maintain general anaesthesia (loss of consciousness).
Croatian: Sevohale se koristi za davanje i održavanje opće anestezije (gubitka svijesti).
English: Why is Sevohale authorised in the EU?
Croatian: Zašto je Sevohale odobren u EU-u?
English: This summary was last updated in March 2018.
Croatian: Ovaj pregled informacija posljednji je put ažuriran u 3. 2018.
English: Sevoflurane mimics the action of GABA, a substance that naturally reduces brain activity, and blocks the action of glutamate, which stimulates the action of the brain.
Croatian: Sevofluran oponaša djelovanje GABA-e, tvari koja prirodnim putem smanjuje aktivnost mozga i blokira djelovanje glutamata, koji stimulira aktivnost mozga.
English: What are the precautions for the person who gives the medicine or comes into contact with the animal?
Croatian: Kojih se mjera opreza mora pridržavati osoba koja primjenjuje veterinarskomedicinski proizvod ili dolazi u kontakt sa životinjom?
English: Other information about Sevohale
Croatian: Ostale informacije o VMP-u Sevohale
English: This means that Sevohale contains the same active substance and works in the same way as a ‘reference medicine' already authorised in the European Union (EU) called SevoFlo.
Croatian: To znači da Sevohale sadrži istu djelatnu tvar i djeluje na isti način kao i „referentni VMP” koji je već odobren u Europskoj uniji (EU) pod nazivom SevoFlo.
English: The European Medicines Agency concluded that, in accordance with EU requirements, Sevohale has been shown to be comparable to SevoFlo.
Croatian: Europska agencija za lijekove zaključila je kako je, u skladu sa zahtjevima EU-a, utvrđeno da je VMP Sevohale usporediv s VMP-om SevoFlo.
English: Sevohale is a general anaesthetic for dogs and cats.
Croatian: Sevohale je opći anestetik za pse i mačke.
English: The dog or cat breathes in this gas mixture, which causes it to become unconscious.
Croatian: Pas ili mačka udišu tu smjesu plinova koja uzrokuje njihovu nesvijest.
English: An overview of Sevohale and why it is authorised in the EU
Croatian: Pregled VMP-a Sevohale i zašto je odobren u EU-u
English: It contains the active substance sevoflurane, a chemical which is a liquid at room temperature, but when heated becomes a gas (vaporises).
Croatian: Sadrži djelatnu tvar sevofluran, kemikaliju koja je tekuća pri sobnoj temperaturi, ali pri zagrijavanju prelazi u plinovito stanje (isparava).
English: Sevohale is a ‘generic medicine'.
Croatian: Sevohale je „generički VMP”.
English: Sevocalm received a marketing authorisation valid throughout the EU on 21/06/2016.
Croatian: Za VMP Sevocalm izdano je odobrenje za stavljanje u promet koje je na snazi u Europskoj uniji od 21. lipnja 2016.
English: Therefore, the Agency's view was that, as for SevoFlo, the benefits outweigh the identified risks and it can be authorised for use in the EU.
Croatian: Stoga je stav Agencije da, kao i kod VMP-a SevoFlo, koristi nadmašuju identificirane rizike te da VMP može biti odobren za primjenu u EU-u.
English: No additional studies were needed as Sevohale is a generic medicine that is given by inhalation and contains the same active substance as the reference medicine, SevoFlo.
Croatian: Nisu bila potrebna dodatna ispitivanja jer je Sevohale generički VMP koji se udiše i sadrži istu djelatnu tvar kao i referentni VMP SevoFlo.
English: Because Sevohale is a generic medicine, its benefits and risks are taken as being the same as the reference medicine's.
Croatian: Budući da je Sevohale generički VMP, smatra se da su njegove koristi i rizici isti kao i oni referentnog VMP-a.
English: How is Sevohale used?
Croatian: Kako se Sevohale koristi?
English: Safety information has been included in the summary of product characteristics and the package leaflet for Sevohale, including the appropriate precautions to be followed by healthcare professionals and animal owners or keepers.
Croatian: U sažetku opisa svojstava, kao i u uputi o VMP-u Sevohale, nalaze se informacije o sigurnosti primjene, uključujući odgovarajuće mjere opreza kojih se veterinari te vlasnici životinja ili uzgajivači trebaju pridržavati.
English: How does Sevohale work?
Croatian: Kako djeluje Sevohale?
English: For more information about using Sevohale, see the package leaflet or contact your veterinarian or pharmacist.
Croatian: Za dodatne informacije o primjeni VMP-a Sevohale pogledajte uputu o VMP-u, odnosno obratite se veterinaru ili ljekarniku.
English: How has Sevohale been studied?
Croatian: Kako je VMP Sevohale ispitivan?
English: ATCvet code: QI02AA04.
Croatian: ATCvet kod: QI02AA04.
English: Revaccination: every six months.
Croatian: Ponovno cijepljenje: svakih šest mjeseci.
English: In trials the following has been demonstrated:
Croatian: Ispitivanja su pokazala sljedeće:
English: Use only accordingly to the benefit/risk assessment by the responsible veterinarian.
Croatian: Koristiti samo u skladu s procjenom koristi / rizika od strane odgovornog veterinara.
English: Schedule should be adjusted accordingly (see section 4.9).
Croatian: U skladu s tim treba prilagoditi plan (vidi poglavlje 4.9).
English: Each dose of 2 ml of emulsion contains:
Croatian: Jedna doza od 2 ml emulzije sadrži:
English: If you notice any side effects, even those not already listed in this package leaflet or you think that the medicine has not worked, please inform your veterinary surgeon.
Croatian: Ako primijetite bilo kakve nuspojave, čak i one koje nisu već navedene u ovom paketu ili mislite da lijek nije djelovao, obavijestite svog veterinara.
English: Avoid accidental contamination of the vaccine after first broaching and during use.
Croatian: Izbjegavajte slučajne kontaminacije cjepiva nakon prvog izvlačenja i tijekom uporabe.
English: Do not warm the product before use.
Croatian: Ne zagrijavati proizvod prije primjene.
English: a) the administration of the product to animals will interfere with the implementation of national programme for the diagnosis, control or eradication of animal diseases, or will cause difficulties in certifying the absence of contamination in live animals or in foodstuffs or other products obtained from treated animals.
Croatian: a) će primjena proizvoda na životinjama interferirati s provedbom nacionalnog programa za otkrivanje, kontrolu ili iskorjenjivanje bolesti životinja ili će prouzročiti poteškoće u certificiranju odsutnosti zaraze u živih životinja ili hrani ili drugim proizvodima dobivenim od tretiranih životinja.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY NUMBER OF DOSES
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI BROJU DOZA 10 doza
English: The number and type of strains included in the final product will be adapted to the current epidemiological situation at the time of formulation of the final product and will be shown on the label.
Croatian: Broj i vrsta sojeva koje će sadržavati konačni veterinarsko-medicinski proizvod prilagodit će se trenutačnoj epidemiološkoj situaciji u vrijeme formulacije konačnog proizvoda i bit će naznačen na etiketi.
English: In cattle, the antibody levels measured were above those shown to be protective.
Croatian: U goveda su izmjerene razine protutijela iznad dokazanih zaštitnih razina.
English: These local reactions normally resolve over a period of four weeks post vaccination, but may persist for longer in a small number of animals.
Croatian: Te se lokalne reakcije obično povuku u razdoblju od četiri tjedna nakon cijepljenja, no mogu trajati i duže kod manjeg broja životinja.
English: Do not mix the vaccine by vigorous shaking because it leads to entrapment of air bubbles.
Croatian: Ne miješajte cjepivo snažnim protresanjem jer time stvarate zračne mjehuriće.
English: BOEHRINGER INGELHEIM ANIMAL HEALTH Netherlands B.V. Houtribweg 39
Croatian: BOEHRINGER INGELHEIM ANIMAL HEALTH Netherlands B.V.
English: Emulsion for injection.
Croatian: OBLIK Emulzija za injekciju.
English: Schedule should be adjusted accordingly (see section “dosage”).
Croatian: U skladu s tim treba prilagoditi plan (vidi poglavlje „doziranje“).
English: The excipients (including adjuvants) listed in section 6.1 of the SPC are either allowed substances for which table 1 of the annex to Commission Regulation (EU) No 37/2010 indicates that no MRLs are required or considered as not falling within the scope of Regulation (EC) No 470/2009 when used as in this veterinary medicinal product.
Croatian: Pomoćne tvari (uključujući adjuvanse) navedene u dijelu 6.1 SPC su ili dozvoljene tvari za koje je u tablici 1, Dodatka Uredbe Komisije (EU) br. 37/2010 navedeno da određivanje MRL nije nužno, ili se smatra da se na njih ne primjenjuju odredbe Uredbe (EK) br. 470/2009 kada se primjenjuju u tom veterinarsko-medicinskom proizvodu.
English: EXP {month/year} Once broached use immediately.
Croatian: ROK VALJANOSTI EXP {mjesec/godina} Jednom otvoren odmah primijeniti.
English: White emulsion after shaking.
Croatian: Bijela emulzija nakon protresanja.
English: Pigs: 4 weeks after vaccination.
Croatian: Svinje: 4 tjedna nakon cijepljenja.
English: No antibodies to NSP were detected using the PrioCHECK FMDV NS test kit:
Croatian: Nisu otkrivena protutijela na NSP primjenom kompleta za ispitivanje PrioCHECK FMDV NS:
English: Mannide mono-oleate Polysorbate 80
Croatian: Parafin, tekući Manid mono-oleat Polisorbat 80
English: The use of a multiple injection device is recommended.
Croatian: Preporučuje se primjena uređaja za višestruko injiciranje.
English: 10 doses 25 doses 50 doses 100 doses 150 doses 10 x 10 doses 10 x 25 doses 10 x 50 doses 10 x 100 doses 10 x 150 doses
Croatian: 10 doza 25 doza 50 doza 100 doza 150 doza 10 x 10 doza 10 x 25 doza 10 x 50 doza 10 x 100 doza 10 x 150 doza
English: THE WORDS “FOR ANIMAL TREATMENT ONLY” AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, if applicable
Croatian: 13. RIJEČI „SAMO ZA PRIMJENU NA ŽIVOTINJAMA“ I UVJETI ILI OGRANIČENJA U POGLEDU OPSKRBE I PRIMJENE, AKO JE PRIMJENJIVO
English: Polypropylene bottle with a nitrile elastomer closure and sealed with an aluminium cap.
Croatian: Polipropilenska boca s nitrilnim elastomernim zatvaračem i zatvorena aluminijskim čepom.
English: Maternal antibodies may interfere with vaccination.
Croatian: Majčinska protutijela mogu interferirati sa cijepljenjem.
English: The use of this veterinary medicinal product is only allowed under the particular conditions established by European Community legislation on the control of foot-and-mouth disease.
Croatian: Primjena ovog veterinarsko-medicinskog proizvoda dopuštena je samo u određenim uvjetima utvrđenim zakonodavstvom Europske zajednice u pogledu kontrole bolesti slinavke i šapa.
English: Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency (http://www.ema.europa.eu).
Croatian: Detaljne informacije o ovom veterinarsko-medicinskom proizvodu dostupne su na web-stranici Europske agencije za lijekove (http://www.ema.europa.eu).
English: Date of first authorisation: 15/07/2013 Date of last renewal: 14/06/2018
Croatian: Datum zadnjeg produljenja: 14/06/2018
English: Homogenize the content of the vial by gentle mixing before the insertion of needle.
Croatian: Homogenizirajte sadržaj bočice blagim miješanjem prije umetanja igle.
English: Cattle and sheep: 7 days after vaccination.
Croatian: Goveda i ovce: 7 dana nakon cijepljenja.
English: Major incompatibilities: Do not mix with any other veterinary medicinal product.
Croatian: Glavne inkompatibilnosti: Ne miješati s bilo kojim drugim veterinarsko-medicinskim proizvodimom.
English: Accidental injection/self-injection may result in severe pain and swelling, particularly if injected into a joint or finger, and in rare cases could result in the loss of the affected finger if prompt medical attention is not given.
Croatian: Nehotična injekcija/samo injiciranje može prouzročiti jaku bol i oticanje, naročito ako se injicira u zglob prsta, a u rijetkim slučajevima može rezultirati gubitkom zahvaćenog prsta ako nije pružena hitna medicinska pomoć.
English: MANUFACTURER RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. STATEMENT OF THE MRLs
Croatian: ODGOVORAN ZA PUŠTANJE SERIJE U PROMET B. UVJETI ILI OGRANIČENJA U POGLEDU OPSKRBE I PRIMJENE C. IZVJEŠĆE O MRL
English: This is best achieved by inverting the vial several times base over apex.
Croatian: To se najbolje postiže preokretanjem bočice nekoliko puta od vrha prema dnu.
English: A slight increase of rectal temperature of up to 1.2 °C for 4 days post-vaccination with no other generalised clinical signs is commonly observed.
Croatian: Često je prisutan blagi porast rektalne temperature do 1,2°C tijekom 4 dana nakon cijepljenja bez drugih generaliziranih kliničkih simptoma.
English: Shelf life after first opening the immediate packaging: use immediately.
Croatian: Rok valjanosti poslije prvog otvaranja unutarnjeg pakovanja: odmah primijeniti.
English: DOSAGE FOR EACH SPECIES, ROUTES AND METHOD OF ADMINISTRATION
Croatian: DOZIRANJE ZA SVAKU CILJNU VRSTU ŽIVOTINJA, PUTEVI I NAČIN PRIMJENE
English: The import, possession, sale, supply and/or use of this veterinary medicinal product may be prohibited in a Member State on the whole or part of its territory, see package leaflet for further information.
Croatian: Uvoz, prodaja, opskrba i/ili primjena ovog veterinarsko-medicinskog proizvoda može biti zabranjena u državi članici na cijelom ili na dijelu njenog teritorija, za daljnje informacije vidi uputu o VMP.
English: Sodium chloride Potassium dihydrogen phosphate Potassium chloride Disodium phosphate anhydrous Potassium hydroxide Water for injections.
Croatian: Natrijev klorid Kalij-dihidrogenfosfat Kalijev klorid Dinatrijev fosfat, bezvodni Kalijev hidroksid Voda za injekcije.
English: * PD50 - 50% protective dose in cattle as described in Ph. Eur.
Croatian: * PD50 - 50% zaštitne doze (PD) za goveda kako je propisano u monografiji Europske farmakopeje (Ph.
English: 10 doses 25 doses
Croatian: 25 doza
English: If you are accidentally injected with this product, seek prompt medical advice even if only a very small amount is injected and take the package leaflet with you.
Croatian: Ukoliko dođe do nehotičnog injiciranja ovim veterinarsko-medicinskim proizvodom, potražite hitnu medicinsku pomoć čak ako je injicirana vrlo mala količina i sa sobom ponesite uputu o VMP.
English: Any person intending to manufacture, import, possess, sell, supply and use this veterinary medicinal product must first consult the relevant Member State's competent authority on the current vaccination policies, as these activities may be prohibited in a Member State on the whole or part of its territory pursuant to national legislation.
Croatian: Tko namjerava proizvoditi, uvoziti, posjedovati, prodavati, opskrbljivati i primjenjivati ovaj veterinarsko-medicinski proizvod mora se savjetovati s nadležnim tijelom odnosne države članice u pogledu važećih odredbi o cijepljenju jer ta aktivnost može biti zabranjena u državama članicama na cijelom ili na dijelu njihovog teritorija sukladno nacionalnom zakonodavstvu.
English: Following repeated administration at short intervals, the intensity of these reactions may be increased.
Croatian: Nakon ponovljenih primjena u kratkim intervalima moguće je da će te reakcije biti pojačanog intenziteta.