FrancophonIA/ELRC3.0 huggingface dataset:
English: Pharmacotherapeutic group: Psycholeptics, hypnotics and sedatives ATCvet code: QN05CM18
Croatian: Farmakoterapijska grupa: Psiholeptici, hipnotici i sedativi ATCvet kod: QN05CM18.
English: Care should be taken to avoid self-injection.
Croatian: Potreban je oprez kako bi se izbjeglo samoinjiciranje.
English: It is recommended that animals are fasted for 12 hours prior to Cepedex administration.
Croatian: Preporuča se da životinje prije primjene Cepedexa budu 12 sati natašte.
English: Muscle tremors may occur during sedation.
Croatian: Mišićni tremor može se javiti tijekom sedacije.
English: Do not use in animals with cardiovascular disorders.
Croatian: Ne primjenjivati na životinjama s poremećajima kardiovaskularnog sustava.
English: Therefore the use of the product during pregnancy and lactation is not recommended.
Croatian: Stoga se korištenje proizvoda tijekom graviditeta i laktacije ne preporučuje.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the package after EXP.
Croatian: Ne koristiti ovaj veterinarsko-medicinski proizvod poslije isteka roka valjanosti naznačenog na pakiranju nakon EXP (skraćenica za rok valjanosti).
English: In case of skin or mucosal contact, wash the exposed skin immediately after exposure with large amounts of water and remove contaminated clothes that are in direct contact with skin.
Croatian: U slučaju kontakta s kožom ili sluznicom, odmah nakon izloženosti oprati eksponiranu kožu velikim količinama vode i skinuti kontaminiranu odjeću koja je u direktnom kontaktu s kožom.
English: The elimination half-life (t1⁄2) is 40-50 minutes.
Croatian: Poluvrijeme eliminacije (t½) iznosi 40-50 minuta.
English: Nervous, aggressive or excited animals should be given the possibility to calm down before initiation of treatment.
Croatian: Nervoznim, agresivnim ili uzbuđenim životinjama treba prije početka liječenja dati vremena da se smire.
English: After treatment, the animal should not be given water or food before it is able to swallow.
Croatian: Nakon tretmana, životinji se ne smije dati voda ili hrana prije nego što je sposobna gutati.
English: Vomiting, hypothermia and nervousness have been reported after such use.
Croatian: hipotermija i nervoza zabilježeni su nakon takve primjene.
English: In a clinical study, dexmedetomidine contributed to postoperative analgesia for 0.5 - 4 hours.
Croatian: U kliničkom je ispitivanju deksmedetomidin doprinio postoperativnoj analgeziji kroz 0,5 - 4 sata.
English: Vomiting may occur 5-10 minutes after injection.
Croatian: Do povraćanja može doći 5-10 minuta nakon injiciranja.
English: Methyl parahydroxybenzoate (E 218)
Croatian: Metil parahidroksibenzoat (E 218)
English: Ask your veterinary surgeon or pharmacist how to dispose of medicines no longer required.
Croatian: Upitajte svojeg veterinara ili ljekarnika o načinu odlaganja nepotrebnih lijekova.
English: In some dogs and cats, a decrease in respiratory rate may occur.
Croatian: U nekih pasa i mačaka može doći do smanjenja frekvencije disanja.
English: In case of eye contact, rinse abundantly with fresh water.
Croatian: U slučaju kontakta s očima, obilno se umiti svježom vodom.
English: In clinical trials the incidence of hypoxaemia was common, especially within the 15 first minutes into dexmedetomidine-ketamine anaesthesia.
Croatian: U kliničkim ispitivanjima hipoksemija je bila česta, pogotovo unutar prvih 15 minuta deksmedetomidin-ketaminske anestezije.
English: Sedation lasts for at least 120 minutes post administration and analgesia lasts for at least 90 minutes.
Croatian: Sedacija traje najmanje 120 minuta nakon primjene, a analgezija najmanje 90 minuta.
English: Dexmedetomidine is a potent and selective α2-adrenoceptor agonist that inhibits the release of noradrenaline from noradrenergic neurons.
Croatian: Deksmedetomidin je potentni i selektivni agonist α2-adrenergičkih receptora koji inhibira otpuštanje noradrenalina iz noradrenergičkih neurona.
English: ANNEX II
Croatian: DODATAK II.
English: The duration and depth of the sedation and analgesia are dose-dependent.
Croatian: Trajanje i dubina sedacije i anestezije ovisni su o dozi.
English: Dog Weight
Croatian: Težina psa
English: Metabolites are excreted mainly in the urine (51% of the dose), and to a lesser extent in the faeces.
Croatian: Metaboliti se većinom izlučuju mokraćom (51% doze) te u manjoj mjeri stolicom.
English: The administration of dexmedetomidine to puppies younger than 16 weeks and kittens younger than 12 weeks has not been studied.
Croatian: Primjena deksmedetomidina na štencima mlađim od 16 tjedana i mačićima mlađim od 12 tjedana nije ispitivana.
English: Premedication in dogs and cats before induction and maintenance of general anaesthesia.
Croatian: Premedikacija u pasa i mačaka prije uvođenja i održavanja opće anestezije.
English: Dexmedetomidine is compatible with butorphanol and ketamine in the same syringe at least for two hours.
Croatian: Deksmedetomidin je kompatibilan s butorfanolom i ketaminom u istoj štrcaljki kroz najmanje dva sata.
English: Dexmedetomidine is also rapidly distributed in the body and penetrates the blood-brain barrier readily.
Croatian: Deksmedetomidin se također brzo distribuira po organizmu i lako prolazi krvno moždanu barijeru.
English: Respiration rate can occasionally decrease.
Croatian: Ponekad može doći do smanjenja frekvencije disanja.
English: Biotransformations in the cat occur by hydroxylation in the liver.
Croatian: Biotransformacija se u mačke odvija hidroksilacijom u jetri.
English: The premedication dose of dexmedetomidine is 125 - 375 micrograms/square metre body surface area, administered 20 minutes prior to induction for procedures requiring anaesthesia.
Croatian: Premedikacijska doza deksmedetomidina iznosi 125 - 375 mikrograma/četvornom metru površine tijela, primijenjeno 20 minuta prije indukcije za postupke u kojima je potrebna anestezija.
English: Due to peripheral vasoconstriction and venous desaturation in the presence of normal arterial oxygenation, the mucous membranes may appear pale and/or with a blue tinge.
Croatian: Zbog periferne vazokonstrikcije i venske desaturacije uz normalnu arterijsku oksigenaciju, sluznice mogu izgledati blijede i/ili poprimiti plavkastu nijansu.
English: Respiratory and haemodynamic symptoms should be treated symptomatically.
Croatian: Respiratorne i hemodinamičke simptome treba liječiti simptomatski.
English: The bioavailability of dexmedetomidine is 60% and the apparent volume of distribution (Vd) is 0.9 l/kg.
Croatian: Bioraspoloživost deksmedetomidina iznosi 60%, a prividni volumen raspodjele (Vd) iznosi 0,9 l/kg.
English: Date of first authorisation:13/12/2016 <Date of last renewal:> <{DD/MM/YYYY}> <{DD month YYYY}.>
Croatian: Datum prvog odobrenja: 13/12/2016.
English: A slight decrease in temperature may be observed.
Croatian: Može se primijetiti blago snižavanje tjelesne temperature.
English: Concomitant use of dexmedetomidine and butorphanol produces sedative and analgesic effects beginning no later than 15 minutes after administration.
Croatian: Istodobna upotreba deksmedetomidina i butorfanola dovodi do sedativnih i analgetskih učinaka ne kasnije od 15 minuta nakon primjene.
English: Dogs: After an intramuscular dose of 50 micrograms/kg a maximum concentration in plasma of about 12 nanograms/ml is reached after 0.6 hours.
Croatian: Psi: Nakon intramuskularne doze od 50 mikrograma/kg, maksimalna koncentracija u plazmi od otprilike 12 nanograma/ml postiže se nakon 0,6 sati.
English: 4.10 Overdose (symptoms, emergency procedures, antidotes)
Croatian: 4.10 Predoziranje (simptomi, hitni postupci, antidoti) , ako je nužno
English: This veterinary medicinal product does not require any special storage conditions.
Croatian: Ovaj veterinarsko-medicinski proizvod ne zahtijeva posebne uvjete čuvanja.
English: Dexmedetomidine, butorphanol and/or ketamine can be mixed in the same syringe as they have been shown to be pharmaceutically compatible.
Croatian: Deksmedetomidin, butorfanol i/ili ketamin mogu se miješati u istoj štrcaljki, budući da je ustanovljeno da su farmaceutski kompatibilni.
English: Atipamezole should not be administered prior to 30 minutes following ketamine administration.
Croatian: Atipamezol ne bi trebalo primijeniti prije nego što je prošlo 30 minuta od primjene ketamina.
English: Administration of atipamezole after dexmedetomidine rapidly reverses the effects and thus shortens the recovery period.
Croatian: Primjena atipamezola nakon deksmedetomidina brzo prekida njegove učinke pa stoga skraćuje period oporavka.
English: Deep sedation and analgesia in dogs in concomitant use with butorphanol for medical and minor surgical procedures.
Croatian: Duboka sedacija i analgezija u pasa i istodobna primjena s butorfanolom za medicinske i manje kirurške zahvate.
English: Atipamezole does not reverse the effect of ketamine.
Croatian: Atipamezol ne prekida učinak ketamina.
English: Solution for injection
Croatian: Voda za injekcije
English: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Croatian: Bilo koji neupotrijebljeni veterinarsko-medicinski proizvod ili otpadni materijali dobiveni primjenom tih veterinarsko-medicinskih proizvoda mora se odlagati u skladu s lokalnim propisima.
English: Dexmedetomidine is a sedative and sleep inducing drug.
Croatian: Deksmedetomidin je sedativ i sredstvo za spavanje.
English: Dogs: Dexmedetomidine doses are based on body surface area:
Croatian: Doze deksmedetomidina određuju se prema površini tijela:
English: By virtue of its α2-adrenergic activity, dexmedetomidine causes a decrease in heart rate and body temperature.
Croatian: Svojom α2-adrenergičkom aktivnošću deksmedetomidin dovodi do pada srčane frekvencije i tjelesne temperature.
English: As a lipophilic compound, dexmedetomidine is well absorbed after intramuscular administration.
Croatian: Kao lipofilna tvar, deksmedetomidin se dobro apsorbira nakon intramuskularne primjene.
English: In a clinical study, the requirement for propofol was reduced by 50%.
Croatian: U kliničkom ispitivanju potreba za propofolom je smanjena za 50%.
English: Cepedex contains dexmedetomidine as the active substance, which produces sedation and analgesia in dogs and cats.
Croatian: Cepedex kao djelatnu tvar sadrži deksmedetomidin, koji dovodi do sedacije i analgezije u pasa i mačaka.
English: To be used with precaution in elderly animals.
Croatian: Na starijim životinjama primjenjivati s oprezom.
English: Rare instances of pulmonary oedema have been reported.
Croatian: Zabilježeni su rijetki slučajevi edema pluća.
English: When dexmedetomidine and ketamine are used sequentially, with a 10 minute interval, cats may occasionally experience AV-block or extrasystole.
Croatian: Kad se deksmedetomidin i ketamin koriste sekvencijalno, unutar 10-minutnog intervala u mačaka može ponekad doći do AV bloka ili ekstrasistole.
English: <{MM/YYYY}>
Croatian: {MM/GGGG}
English: For non-invasive, mildly to moderately painful procedures and examinations requiring restraint, sedation and analgesia:
Croatian: Za neinvazivne, blago do umjereno bolne zahvate koji zahtijevaju obuzdavanje, sedaciju i analgeziju:
English: Major biotransformations in the dog include hydroxylation, glucuronic acid conjugation and Nmethylation in the liver.
Croatian: Glavne biotransformacije u psa uključuju hidroksilaciju, konjugaciju s glukuronskom kiselinom i Nmetilaciju u jetri.
English: Non-invasive, mildly to moderately painful, procedures and examinations which require restraint, sedation and analgesia in dogs and cats.
Croatian: Neinvazivni, blago do umjereno bolni zahvati i pregledi koji zahtijevaju obuzdavanje, sedaciju i analgeziju u pasa i mačaka.
English: THE WORDS "FOR ANIMAL TREATMENT ONLY" AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, IF APPLICABLE
Croatian: 13. RIJEČI “SAMO ZA PRIMJENU NA ŽIVOTINJAMA” I UVJETI ILI OGRANIČENJA
English: Use during pregnancy and lactation
Croatian: Primjena tijekom graviditeta ili laktacije
English: Cat Weight
Croatian: Težina mačke
English: Cats: After a 40 micrograms/kg bw intramuscular dose the Cmax is 17 ng/ml.
Croatian: Mačke: Nakon intramuskularne doze od 40 mikrograma/kg tjelesne težine Cmax iznosi 17 ng/ml.
English: Anticholinergics should be used with caution with dexmedetomidine.
Croatian: Antikolinergike je uz deksmedetomidin potrebno koristiti s oprezom.
English: Propyl parahydroxybenzoate
Croatian: Propil parahidroksibenzoat
English: Expected respiratory events are bradypnoea, intermittent respiratory patterns, hypoventilation, and apnoea.
Croatian: Očekivane promjene disanja su bradipneja, intermitentni obrasci respiracije, hipoventilacija i apneja.
English: Do not use in case of known hypersensitivity to the active substance or to any of the excipients.
Croatian: Ne primjenjivati u slučaju preosjetljivosti na djelatnu tvar ili na bilo koju od pomoćnih tvari.
English: Sick and debilitated dogs and cats should only be premedicated with dexmedetomidine before induction and maintenance of general anaesthesia based on a risk-benefit assessment.
Croatian: Bolesni i oslabljeni psi i mačke trebali bi primiti premedikaciju deksmedetomidinom prije uvođenja i održavanja opće anestezije samo na osnovi procjene rizika i koristi.
English: Cardboard box pack sizes:
Croatian: Veličina kartonskih pakovanja:
English: After concurrent exposure to an overdose of dexmedetomidine (3 times the recommended dose) and 15 mg ketamine/ kg, atipamezole can be administered at the recommended dose level for reversal of effects induced by dexmedetomidine.
Croatian: Nakon istodobne izloženosti predoziranju deksmedetomidinom (trostruka preporučena doza) i 15 mg ketamina/kg, atipamezol se može primijeniti u preporučenoj dozi za poništavanje učinaka deksmedetomidina.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Croatian: Učestalost nuspojava je određena sukladno sljedećim pravilima: - vrlo česte (više od 1 na 10 tretiranih životinja pokazuju nuspojavu(e)) - česte (više od 1 ali manje od 10 životinja na 100 tretiranih životinja) - manje česte (više od 1 ali manje od 10 životinja na 1.000 tretiranih životinja)
English: Intramuscular dosing at 40 micrograms/kg (followed by ketamine or propofol) frequently resulted in sinus bradycardia and sinus arrhythmia, occasionally resulted in 1st degree atrioventricular block, and rarely resulted in supraventricular premature depolarizations, atrial bigeminy, sinus pauses, 2nd degree atrioventricular block, or escape beats/rhythms.
Croatian: Intramuskularna primjena doze od 40 mikrograma/kg (potom primjena ketamina i propofola) često je dovodila do sinusne bradikardije i sinusne aritmije, ponekad do AV bloka 1. stupnja, i rijetko do prijevremenih supraventrikularnih depolarizacija, atrijske bigeminije, sinusnih pauza, AV bloka 2. stupnja, ekstrasistole.
English: (equivalent to dexmedetomidine
Croatian: (ekvivalentno deksmedetomidinu
English: Dexmedetomidine also induces a number of other α2-adrenoceptor mediated effects, which include piloerection, depression of motor and secretory functions of the gastrointestinal tract, diuresis and hyperglycaemia.
Croatian: Deksmedetomidin također dovodi do niza učinaka posredovanih α2-adrenergičkim receptorima, uključujući kostriješenje, smanjenje motornih i sekretornih funkcija gastrointestinalnog sustava, mokrenje i hiperglikemiju.
English: The specific α2-adrenoceptor antagonist, atipamezole, which is approved for use in animals, has been used in humans only experimentally to antagonize dexmedetomidine-induced effects.
Croatian: Specifični α2 -adrenoreceptorski antagonist, atipamezol, koji je odobren za upotrebu na životinjama, upotrebljavan je u ljudi samo eksperimentalno za poništavanje učinaka deksmedetomidina.
English: A prolonged elimination half-life is therefore expected with overdoses or when dexmedetomidine is coadministered with other substances, which affect hepatic circulation.
Croatian: Povećanje poluvremena eliminacije očekuje se stoga kod predoziranja ili kad se deksmedetomidin istodobno primjenjuje s drugim tvarima koje utječu na protok krvi kroz jetru.
English: Advice to physicians: Cepedex is an α2-adrenoreceptor agonist, symptoms after absorption may involve clinical effects including dose-dependent sedation, respiratory depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia.
Croatian: Savjet liječnicima: Cepedex je agonist α2-adrenergičkih receptora, simptomi nakon apsorpcije mogu uključivati kliničke učinke, uključujući sedaciju ovisnu o dozi, depresiju disanja, bradikardiju, hipotenziju, suhoću usne šupljine i hiperglikemiju.
English: These may include profound sinus bradycardia, 1st and 2nd degree AV block, sinus arrest or pause, as well as atrial, supraventricular and ventricular premature complexes.
Croatian: One mogu uključivati tešku sinusnu bradikardiju, AV blok 1. i 2. stupnja, sinusni arest ili pauzu, kao i atrijske, supraventrikularne i ventrikularne ekstrasistole.
English: The safety of dexmedetomidine has not been established in males intended for breeding.
Croatian: Neškodljivost deksmedetomidina nije utvrđena na mužjacima namijenjenima za rasplod.
English: Anaesthesia can be induced 10 minutes after premedication by intramuscular administration of a target dose of 5 mg ketamine/ kg bw or by intravenous administration of propofol to effect.
Croatian: Uvođenje u anesteziju postiže se 10 minuta nakon premedikacije intramuskularnom primjenom ciljne doze od 5 mg ketamina/kg tjelesne težine, ili intravenskom primjenom propofola do nastupa učinka.
English: Brady- and tachyarrhythmias have been reported.
Croatian: Zabilježene su bradiaritmije i tahiaritmije.
English: People with known hypersensitivity to the active substance or any of the excipients should administer the product with caution.
Croatian: Osobe s poznatom preosjetljivošću na djelatnu tvar ili na bilo koju od pomoćnih tvari trebale bi primjenjivati proizvod s oprezom.
English: Overdose (symptoms, emergency procedures, antidotes) Dogs:
Croatian: Predoziranje (simptomi, postupci u hitnom slučaju, protulijekovi)
English: The safety of dexmedetomidine has not been established during pregnancy and lactation in the target species.
Croatian: Neškodljivost deksmedetomidina nije utvrđena tijekom graviditeta i laktacije u ispitivanim vrstama.
English: The apparent volume of distribution (Vd) is 2.2 l/kg and the elimination half-life (t1⁄2) is one hour.
Croatian: Prividni volumen raspodjele (Vd) iznosi 2,2 l/kg, a poluvrijeme eliminacije (t½) jedan sat.
English: Sodium hydroxide (E 524) (for pH adjustment) Hydrochloric acid (E507) (for pH adjustment) Water for injections
Croatian: Natrijev hidroksid (E 524) (za podešavanje pH)
English: The veterinary medicinal product is intended for: - Dogs: intravenous or intramuscular use - Cats: intramuscular use
Croatian: Ovaj veterinarsko-medicinski proizvod namijenjen je za: - Pse: intravenska ili intramuskularna primjena.
English: *only IM
Croatian: * samo i.m.
English: Methyl parahydroxybenzoate (E 218) Propyl parahydroxybenzoate Sodium chloride
Croatian: Metil parahidroksibenzoat (E 218) Propil parahidroksibenzoat Natrijev klorid
English: Dexmedetomidine has a high clearance and its elimination depends on the hepatic blood flow.
Croatian: Deksmedetomidin ima veliki klirens i njegova eliminacija ovisi o protoku krvi kroz jetru.
English: In cases of overdose, or if the effects of dexmedetomidine become potentially life- threatening, the appropriate dose of atipamezole is 10 times the initial dose of dexmedetomidine (micrograms/ kg bw or micrograms/ square meter body surface area).
Croatian: U slučajevima predoziranja ili ako učinci deksmedetomidina postanu potencijalno životno ugrožavajući, prikladna doza atipamezola je 10 puta veća od inicijalne doze deksmedetomidina (mikrogrami/kg tjelesne težine ili mikrogrami/četvornom metru površine tijela).
English: The use of other central nervous system depressants is expected to potentiate the effects of dexmedetomidine and therefore an appropriate dose adjustment should be made.
Croatian: Kod primjene drugih depresora središnjeg živčanog sustava očekuje se pojačanje učinka deksmedetomidina pa je stoga potrebna prilagodba doze.
English: Corneal opacities may occur during sedation (see also the section on Special precautions for the use in animals).
Croatian: Za vrijeme sedacije mogu nastati zamućenja rožnice (vidi dio o Posebnim mjerama opreza prilikom primjene na životinjama).
English: The expected sedative and analgesic effects are reached within 15 minutes after administration and are maintained up to 60 minutes after administration.
Croatian: Očekivani sedativni i analgetski učinci postižu se unutar 15 minuta nakon primjene i traju do 60 minuta nakon primjene.
English: Pregnant women should administer the product with special caution to avoid self-injection since uterine contractions and decreased foetal blood pressure may occur after accidental systemic exposure.
Croatian: Trudnice trebaju s velikom opreznošću primjenjivati proizvod kako bi se izbjeglo samoinjiciranje jer nakon slučajne sustavne izloženosti može doći do kontrakcija maternice i sniženja krvnog tlaka u fetalnom krvotoku.
English: Sedation may be reversed with atipamezole (see section 12 on overdose).
Croatian: Sedacija se može prekinuti pomoću atipamezola (vidjeti dio 12. o predoziranju).
English: Blood pressure will increase initially and then return to normal or below normal.
Croatian: Inicijalno dolazi do povišenja krvnog tlaka, a zatim do normalizacije tlaka ili do hipotenzije.
English: Brady- and tachyarrhythmias have been reported and include profound sinus bradycardia, 1st and 2nd degree AV block and sinus arrest.
Croatian: Zabilježene su bradiaritmije i tahiaritmije te uključuju tešku sinusnu bradikardiju, AV blok 1. i 2. stupnja i sinusni arest.
English: SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED VETERINARY MEDICINAL PRODUCTS OR WASTE MATERIALS, IF ANY
Croatian: 13. POSEBNE MJERE OPREZA PRI ODLAGANJU NEUPOTRIJEBLJENIH VETERINARSKO-MEDICINSKIH PROIZVODA ILI OTPADNIH MATERIJALA, AKO IH IMA
English: Dogs: IM, IV Cats: IM
Croatian: Psi: i.m., i.v.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Cardboard box (0.1 mg/ml)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU Kartonska kutija (0,1 mg/ml)
English: All anaesthetic agents used for induction or maintenance of anaesthesia should be administered to effect.
Croatian: Sve bi anestetike korištene za uvođenje u anesteziju ili za održavanje anestezije trebalo primjenjivati do nastupa učinka.
English: A dose of 10 mg ketamine/ kg used concurrently with 40 micrograms dexmedetomidine/ kg may cause tachycardia.
Croatian: Istodobna primjena doze od 10 mg ketamina/kg sa 40 mikrograma deksmedetomidina/kg može uzrokovati tahikardiju.
English: Shelf-life after first opening the immediate packaging: 56 days.
Croatian: Rok valjanosti nakon prvog otvaranja neposrednog pakiranja: 56 dana.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Cardboard box (0.5 mg/ml)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU Kartonska kutija (0,5 mg/ml)
English: Corneal opacities may occur during sedation (see also section 4.5).
Croatian: Zamućenja rožnice mogu se javiti tijekom sedacije (vidjeti dio 4.5).
English: Volatile anaesthetic requirements for maintenance anaesthesia are also reduced.
Croatian: Također je smanjena potreba za inhalacijskim anesteticima tijekom održavanja anestezije.
English: As in dogs dexmedetomidine has a high clearance in cats and its elimination depends on the hepatic blood flow.
Croatian: Kao i u pasa, deksmedetomidin i u mačaka ima veliki klirens, a njegova eliminacija ovisi o protoku krvi kroz jetru.