FrancophonIA/ELRC3.0 huggingface dataset:
English: DUTREBIS is used in combination with other medicines to treat adults, adolescents, and children 6 years of age and older and weighing at least 30 kg who are infected by HIV.
Slovenian: Zdravilo DUTREBIS uporabljamo v kombinaciji z drugimi zdravili za zdravljenje odraslih, mladostnikov in otrok, starih 6 let ali več, s telesno maso vsaj 30 kg, ki so okuženi z virusom HIV.
English: 156 cells/mm
Slovenian: 156 celic/mm
English: Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) which has activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Slovenian: Lamivudin je nukleozidni zaviralec reverzne transkriptaze (NRTI - nucleoside reverse transcriptase inhibitor), ki deluje proti virusu humane imunske pomanjkljivosti (HIV) in virusu hepatitisa B (HBV).
English: Prior to randomization, OBT were selected by the investigator based on the patient's prior treatment history, as well as baseline genotypic and phenotypic viral resistance testing.
Slovenian: Pred randomizacijo so raziskovalci izbrali OBT na osnovi bolnikovega predhodnega zdravljenja in na osnovi testiranja genotipske in fenotipske odpornosti virusa.
English: • muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity.
Slovenian: • šibkost mišic, šibkost, ki se začne v dlaneh in stopalih in se širi navzgor proti trupu, razbijanje srca (palpitacije), tresenje ali hiperaktivnost.
English: A higher risk of lipodystrophy has been associated with individual factors such as older age, and with drug related factors such as longer duration of ART and associated metabolic disturbances.
Slovenian: Večje tveganje za lipodistrofijo je povezano z individualnimi dejavniki, npr. višjo starostjo, in dejavniki, povezanimi z zdravili, npr. z dolgotrajnejšim protiretrovirusnim zdravljenjem in spremljajočimi presnovnimi motnjami.
English: • Swallow the tablet whole (do not crush or chew).
Slovenian: • Tableto morate pogoltniti celo (ne smete je drobiti ali žvečiti).
English: ≤ 100,000 copies/ml CD4-count ≤ 50 cells/mm > 50 and
Slovenian: ≤ 100.000 kopij/ml Število celic CD4 ≤ 50 celic/mm
English: Some patients taking combination treatment for HIV may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki jemljejo kombinirano zdravljenje proti HIV, se lahko pojavi bolezen kosti, imenovana osteonekroza (odmiranje kostnine zaradi nezadostne prekrvavitve kosti).
English: As a general rule, when deciding to use anti-retroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account in order to characterise the safety for the foetus.
Slovenian: Pri odločanju o uporabi protiretrovirusnih zdravil za zdravljenje okužbe z virusom HIV pri nosečnicah in s tem o zmanjševanju tveganja za prenos virusa HIV na novorojenca je za opredelitev varnosti za plod praviloma treba upoštevati podatke iz študij na živalih kot tudi klinične izkušnje pri nosečnicah.
English: 119 cells/mm
Slovenian: 119 celic/mm
English: A modest increase in Cmax (28 %) was observed for zidovudine when administered with lamivudine, however overall exposure (AUC) is not significantly altered.
Slovenian: Cmax zidovudina se je ob uporabi z lamivudinom nekoliko povečala (28 %), celokupna izpostavljenost (AUC) pa se ni pomembno spremenila.
English: DUTREBIS can cause some side effects that you need to talk to your doctor, pharmacist or nurse about.
Slovenian: Zdravilo DUTREBIS lahko povzroči nekatere neželene učinke, o katerih se morate posvetovati z zdravnikom, farmacevtom ali medicinsko sestro.
English: Lamivudine is also available as an oral solution for children over three months of age and who weigh less than 14 kg or for patients who are unable to swallow tablets.
Slovenian: Lamivudin je na voljo tudi kot peroralna raztopina, namenjena otrokom, starejšim od treh mesecev in s telesno maso do 14 kg, in bolnikom, ki ne morejo pogoltniti tablet.
English: trimethoprim /sulfamethoxazole /lamivudine lamivudine AUC 40 %
Slovenian: trimetoprim/sulfametoksazol/lamivudin AUC lamivudina 40 %
English: You can still pass on HIV when taking this medicine, although the risk is lowered by effective therapy.
Slovenian: Med jemanjem tega zdravila lahko še vedno prenesete okužbo s HIV na druge, čeprav učinkovito protiretrovirusno zdravljenje to tveganje zmanjša.
English: The relationship between in vitro susceptibility of HIV to lamivudine and clinical response to lamivudine-containing therapy remains under investigation.
Slovenian: Razmerje med občutljivostjo HIV na lamivudin in vitro in kliničnim odzivom na zdravljenje, ki vključuje lamivudin, še preučujejo.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to CART.
Slovenian: Čeprav je v etiologijo osteonekroze vpletenih več dejavnikov (med njimi uporaba kortikosteroidov, uživanje alkohola, huda imunosupresija in višji indeks telesne mase), so o primerih osteonekroze poročali predvsem pri bolnikih z napredovalo boleznijo HIV in/ali med dolgotrajnim kombiniranim protiretrovirusnim zdravljenjem.
English: It is not known whether raltegravir is secreted in human milk.
Slovenian: Ni znano, ali se raltegravir pri človeku izloča v materino mleko.
English: • Lactic acidosis is more likely to happen in people who have liver problems, or in people who
Slovenian: • Laktacidoza je verjetnejša pri bolnikih, ki imajo težave z jetri, ali tistih z močno prekomerno
English: This variant arises both in vitro and in HIV-1 infected patients treated with lamivudine-containing antiretroviral therapy.
Slovenian: Ta različica se pojavi tako in vitro kot pri bolnikih, okuženih s HIV-1, zdravljenih s protivirusnim zdravljenjem, ki vključuje lamivudin.
English: DUTREBIS contains two medicines: lamivudine and raltegravir.
Slovenian: Zdravilo DUTREBIS vsebuje dve zdravilni učinkovini: lamivudin in raltegravir.
English: If you are the parent of a child taking DUTREBIS, please read this information carefully with your child.
Slovenian: Če ste starš otroka, ki prejema zdravilo DUTREBIS, natančno preberite navodilo skupaj z otrokom.
English: Cross-resistance conferred by the M184V RT is limited within the nucleoside inhibitor class of antiretroviral agents.
Slovenian: Navzkrižna odpornost, ki jo prenaša M184V RT, je omejena na skupino nukleozidnih zaviralcev protiretrovirusnih zdravil.
English: If you do take too many tablets, contact your
Slovenian: Če ste vzeli preveč tablet, se posvetujte z zdravnikom.
English: The treatment difference (raltegravir- efavirenz) was 4.2 % with an associated 95 % CI of (-1.9, 10.3) establishing that raltegravir is non-inferior to efavirenz (p-value for non-inferiority < 0.001).
Slovenian: Razlika med zdravljenjema (raltegravir - efavirenz) je bila 4,2 % (95 % IZ: -1,9, 10,3) in to kaže, da je raltegravir neinferioren efavirenzu (vrednost p za neinferiornost < 0,001).
English: At the highest dose levels, 400 mg/kg/day in females and 250 mg/kg/day in males, systemic exposure was similar to that at the clinical dose of 400 mg twice daily.
Slovenian: Pri največjih odmerkih, za mišje samice 400 mg/kg/dan in za mišje samce 250 mg/kg/dan, je bila sistemska izpostavljenost podobna kot pri kliničnem odmerku 400 mg dvakrat na dan.
English: Lactic acidosis is caused by a build-up of lactic acid in the body.
Slovenian: Laktacidoza je posledica kopičenja mlečne kisline v telesu.
English: Studies using isoform-selective chemical inhibitors and cDNA-expressed UDP-glucuronosyltransferases (UGT) show that UGT1A1 is the main enzyme responsible for the formation of raltegravir-glucuronide.
Slovenian: Študije, v katerih so uporabili kemične zaviralce, selektivne za izooblike, in s cDNA-izražene UDP glukuronoziltransferaze (UGT) kažejo, da je UGT1A1 glavni encim, odgovoren za nastajanje raltegravirjevega glukuronida.
English: DUTREBIS also helps stop the production of an enzyme called “HIV integrase”.
Slovenian: Zdravilo DUTREBIS tudi pomaga ustaviti nastajanje encima, imenovanega "HIV integraza".
English: In a comparison of 30 subjects receiving raltegravir with *28/*28 genotype to 27 subjects with wild-type genotype, the geometric mean ratio (90 % CI) of AUC was 1.41 (0.96, 2.09) and the geometric mean ratio of C12 hr was 1.91 (1.43, 2.55).
Slovenian: Primerjava 30 oseb z genotipom *28/*28 in 27 oseb z divjim genotipom je med uporabo raltegravirja pokazala, da je bilo geometrično povprečno razmerje (90 % IZ) vrednosti AUC 1,41 (0,96, 2,09), geometrično povprečno razmerje C12ur pa 1,91 (1,43, 2,55).
English: In the second study (n=16), the median cerebrospinal fluid concentration was 3 % (range 1 to 61 %) of the corresponding plasma concentration.
Slovenian: V drugi študiji (N = 16) je bila mediana koncentracija v cerebrospinalni tekočini 3 % (razpon: od 1 do 61 %) odgovarjajoče koncentracije v plazmi.
English: If DUTREBIS is missed within 6 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of DUTREBIS as soon as possible.
Slovenian: Če je od časa, ko bolnik ponavadi vzame zdravilo DUTREBIS, minilo do 6 ur, je treba bolniku naročiti, naj pozabljeni predpisani odmerek zdravila DUTREBIS vzame čim prej.
English: For observed C12 hr in BENCHMRK 1 and 2 the coefficient of variation (CV) for inter-subject variability = 212 % and the CV for intra-subject variability = 122 %.
Slovenian: V študijah BENCHMRK 1 in 2 je bil koeficient variacije (KV) variabilnosti C12ur med osebami 212 % in pri posamezni osebi 122 %.
English: Administration of trimethoprim/sulfamethoxazole 160 mg/800 mg results in a 40 % increase in lamivudine exposure, because of the trimethoprim component; the sulfamethoxazole component did not interact.
Slovenian: Uporaba trimetoprima/sulfametoksazola 160 mg/800 mg zaradi trimetoprima poveča izpostavljenost lamivudinu za 40 %, s sulfametoksazolom medsebojno ne deluje.
English: In vitro studies indicate that zidovudine-resistant virus isolates can become zidovudine sensitive when they simultaneously acquire resistance to lamivudine.
Slovenian: Študije in vitro kažejo, da proti zidovudinu odporni izolati lahko postanejo občutljivi na zidovudin, če istočasno pridobijo odpornost proti lamivudinu.
English: The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when the main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim.
Slovenian: Pri sočasnem jemanju drugih zdravil je treba upoštevati možnost nastanka interakcij, zlasti če je glavna pot njihovega izločanja aktivno izločanje skozi ledvice preko transportnega sistema organskih kationov (npr. trimetoprim).
English: Less potent UGT1A1 inhibitors (e.g., indinavir, saquinavir) may also increase plasma levels of raltegravir, but to a lesser extent compared with atazanavir.
Slovenian: Tudi manj močni zaviralci UGT1A1 (npr. indinavir, sakvinavir) lahko zvišajo koncentracijo raltegravirja v plazmi, vendar v manjši meri kot atazanavir.
English: In addition, the film coating contains the following inactive ingredients: hypromellose, lactose monohydrate, triacetin, yellow iron oxide, Indigo Carmine (E132) Aluminium Lake, and titanium dioxide.
Slovenian: Poleg tega vsebuje filmska obloga naslednje neaktivne sestavine: hipromelozo, laktozo monohidrat, triacetin, rumeni železov oksid, indigotin (E132) in titanov dioksid.
English: Limited data show that lamivudine penetrates the central nervous system and reaches the cerebrospinal fluid (CSF).
Slovenian: Skopi podatki kažejo, da lamivudin prehaja v osrednje živčevje in doseže cerebrospinalno tekočino (CSF - cerebrospinal fluid).
English: • allergic rash (including red spots or blotches sometimes with blistering and swelling of
Slovenian: • alergijski izpuščaj (vključno z rdečimi pikami in pegami, včasih z mehurji in
English: Multiple drug antiretroviral therapy containing lamivudine has been shown to be effective in antiretrovirally-naive patients as well as in patients presenting with viruses containing the M184V
Slovenian: Protiretrovirusno zdravljenje z več zdravili, ki vključuje lamivudin, se je izkazalo za učinkovito pri bolnikih, ki še niso prejemali protiretrovirusnega zdravljenja, kot tudi pri bolnikih, okuženih z virusi z mutacijami M184V.
English: Rifampicin reduces plasma levels of raltegravir; the impact on the efficacy of raltegravir is unknown.
Slovenian: Rifampicin zniža koncentracijo raltegravirja v plazmi; vpliv tega na učinkovitost raltegravirja ni znan.
English: The results of long-term carcinogenicity studies with lamivudine in rats and mice did not show any carcinogenic potential relevant for humans.
Slovenian: Rezultati dolgotrajnih študij karcinogenosti z lamivudinom pri podganah in miših niso pokazali karcinogenega potenciala, ki bi bil pomemben za človeka.
English: Since lamivudine is dialysable, continuous haemodialysis could be used in the treatment of overdose, although this has not been studied.
Slovenian: Lamivudin se dializira, tako da bi bilo za zdravljenje prevelikega odmerjanja mogoče uporabiti kontinuirano hemodializo, vendar to ni raziskano.
English: In clinical studies, lamivudine in combination with zidovudine has been shown to reduce HIV-1 viral load and increase CD4 cell count.
Slovenian: Klinične študije so pokazale, da lamivudin v kombinaciji z zidovudinom zmanjša virusno breme HIV-1 in poveča število celic CD4.
English: Co-administration of DUTREBIS with high doses of co-trimoxazole for the treatment of Pneumocystis carinii pneumonia (PCP) and toxoplasmosis should be avoided.
Slovenian: Sočasni uporabi zdravila DUTREBIS z visokimi odmerki kotrimoksazola za zdravljenje pljučnice s Pneumocystis carinii (PCP) in toksoplazmoze se je treba izogibati.
English: HIV-1 resistance to lamivudine involves the development of a M184V amino acid change close to the active site of the viral reverse transcriptase (RT).
Slovenian: Odpornost HIV-1 na lamivudin vključuje pojav aminokislinske spremembe M184V blizu aktivnega mesta virusne reverzne transkriptaze (RT).
English: At Week 240, the treatment difference (raltegravir - efavirenz) was 9.5 % with an associated 95 % CI of (1.7, 17.3).
Slovenian: V 240. tednu je bila razlika med zdravljenjema (raltegravir - efavirenz) 9,5 % (95 % IZ: 1,7, 17,3).
English: In the first study (n=18), the median cerebrospinal fluid concentration was 5.8 % (range 1 to 53.5 %) of the corresponding plasma concentration.
Slovenian: V prvi študiji (N = 18) je bila mediana koncentracija v cerebrospinalni tekočini 5,8 % (v razponu od 1 do 53,5 %) odgovarjajoče koncentracije v plazmi.
English: • medicines containing raltegravair or emtricitabine - used to treat HIV.
Slovenian: • zdravila, ki vsebujejo raltegravir ali emtricitabin - uporabljajo se za zdravljenje okužbe z virusom HIV
English: Raltegravir is eliminated primarily by glucuronidation in the liver.
Slovenian: Raltegravir se v glavnem izloča z glukuronidacijo, ki poteka v jetrih.
English: In addition, raltegravir inhibited viral replication in cultures of mitogen-activated human peripheral blood mononuclear cells infected with diverse, primary clinical isolates of HIV-1, including isolates from 5 non-B subtypes, and isolates resistant to reverse transcriptase inhibitors and protease inhibitors.
Slovenian: Poleg tega je raltegravir zaviral razmnoževanje virusa v kulturah z mitogenom aktiviranih humanih perifernih monocitov, okuženih z različnimi, predvsem kliničnimi izolati virusa HIV-1, vključno z izolati 5 podtipov, razen podtipa B, in izolati, odpornimi na zaviralce reverzne transkriptaze in zaviralce proteaze.
English: Abacavir maintains its antiretroviral activities against lamivudine resistant HIV-1 harbouring only the M184V mutation.
Slovenian: Abakavir ohrani svoje protiretrovirusno delovanje proti HIV-1, ki je odporen na lamivudin in ima le mutacijo M184V.
English: Co-administration of zidovudine with lamivudine results in a 13 % increase in zidovudine exposure and a 28 % increase in peak plasma levels.
Slovenian: Sočasna uporaba zidovudina in lamivudina povzroči 13 % povečanje izpostavljenosti zidovudinu in 28 % povečanje največje koncentracije v plazmi.
English: In vitro data tend to suggest that the continuation of lamivudine in anti-retroviral regimen despite the development of M184V might provide residual anti-retroviral activity (likely through impaired viral fitness).
Slovenian: Podatki, pridobljeni in vitro, nakazujejo, da nadaljnja uporaba lamivudina v protiretrovirusnem režimu lahko kljub razvoju M184V omogoči rezidualno protiretrovirusno aktivnost (verjetno zaradi okvarjene virusne sposobnosti).
English: Of the 126 patients, 96 received the recommended dose of
Slovenian: Od 126 bolnikov jih je 96 prejemalo priporočeni odmerek raltegravirja.
English: For raltegravir, renal clearance of unchanged drug is a minor pathway of elimination.
Slovenian: Za raltegravir je ledvični očistek nespremenjene zdravilne učinkovine manj pomembna pot izločanja.
English: In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after HIV treatment is started.
Slovenian: Pri nekaterih bolnikih z napredovalo okužbo z virusom HIV in predhodno oportunistično okužbo, se lahko kmalu po začetku zdravljenja okužbe z virusom HIV pojavijo znaki in simptomi vnetja zaradi predhodne okužbe.
English: Additional side effects in children and adolescents • hyperactivity
Slovenian: Dodatni neželeni učinki pri otrocih in mladostnikih
English: Similar findings were not observed in rabbits.
Slovenian: Pri kuncih o podobnih izsledkih niso poročali.
English: • interferons taken with or without ribavirin - used to treat hepatitis.
Slovenian: • interferone (z ribavirinom ali brez njega) - uporabljajo se za zdravljenje hepatitisa
English: A study of the pharmacokinetics of raltegravir was performed in adult patients with severe renal insufficiency.
Slovenian: Študijo farmakokinetike raltegravirja so izvedli pri odraslih bolnikih s hudo insuficienco ledvic.
English: The major circulating entity was raltegravir and represented approximately 70 % of the total radioactivity; the remaining radioactivity in plasma was accounted for by raltegravir-glucuronide.
Slovenian: Glavna snov v obtoku je bil raltegravir, na katerega je odpadlo približno 70 % skupne radioaktivnosti, preostala radioaktivnost v plazmi je bila posledica raltegravirjevega glukuronida.
English: The following data are based on findings in separate studies with the individual components of DUTREBIS (lamivudine and raltegravir).
Slovenian: Naslednji podatki temeljijo na izsledkih ločenih študij vsake od obeh posameznih učinkovin zdravila DUTREBIS (lamivudina in raltegravirja).
English: In rats, at a maternal dose of 600 mg/kg/day, mean active substance concentrations in milk were approximately 3-fold greater than in maternal plasma.
Slovenian: Pri podganah, ki so prejemale odmerek 600 mg/kg/dan, so bile srednje koncentracije zdravilne učinkovine v mleku približno 3-krat večje od koncentracij v plazmi matere.
English: The NRTIs (e.g. didanosine, zidovudine) are not eliminated by this mechanism and are unlikely to interact with lamivudine.
Slovenian: NRTI-ji (npr. didanozin, zidovudin) se ne izločajo s tem mehanizmom, zato ni verjetno, da bi
English: For each of the following clinical adverse reactions reported for raltegravir there was at least one serious occurrence: genital herpes, anaemia, immune reconstitution syndrome, depression, mental disorder, suicide attempt, gastritis, hepatitis, renal failure, accidental overdose.
Slovenian: Pri vsakem od naslednjih kliničnih neželenih učinkov, opisanih za raltegravir, je bil vsaj en primer resen: genitalni herpes, anemija, sindrom imunske obnove, depresija, duševne motnje, poskus samomora, gastritis, hepatitis, odpoved ledvic, nenamerno preveliko odmerjanje.
English: Although in vitro studies indicated that raltegravir is not an inhibitor of the UDP glucuronosyltransferases (UGTs) 1A1 and 2B7, one clinical study has suggested that some inhibition of UGT1A1 may occur in vivo based on effects observed on bilirubin glucuronidation.
Slovenian: Čeprav so študije in vitro pokazale, da raltegravir ne zavira UDP glukuronoziltransferaz (UGT) 1A1 in 2B7, je ena klinična študija na podlagi učinkov na glukuronidacijo bilirubina pokazala, da se in vivo lahko pojavi zaviranje UGT1A1.
English: For mean CD4 changes, baseline-carry-forward was used for virologic failures.
Slovenian: Za povprečne spremembe števila celic CD4 so za virološke neuspehe uporabili prenesene izhodiščne vrednosti.
English: Patients with HIV and hepatitis B or C virus co-infection Patients with chronic hepatitis B or C treated with ART are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Slovenian: Bolniki, sočasno okuženi s HIV in virusom hepatitisa B ali C Pri bolnikih s kroničnim hepatitisom B ali C, zdravljenih s protiretrovirusnimi zdravili, obstaja večje tveganje za resne in potencialno smrtne neželene učinke na jetra.
English: This does not require dose adjustment unless the patient also has renal impairment (see sections 4.5 and 4.2).
Slovenian: Vendar to ne zahteva prilagoditve odmerka, razen če ima bolnik tudi okvaro ledvic (glejte poglavji 4.5 in 4.2).
English: Viruses harbouring a mutation at amino acid 148, along with one or more other raltegravir resistance mutations, may also have clinically
Slovenian: Virusi z mutacijo aminokisline 148 skupaj z eno ali več drugimi mutacijami odpornosti na raltegravir so lahko klinično pomembno odporni tudi na dolutegravir.
English: • DUTREBIS is not recommended in pregnancy.
Slovenian: • Zdravila DUTREBIS ni priporočljivo uporabljati med nosečnostjo.
English: The pharmacokinetics of lamivudine after administration to patients over 65 years of age have not been studied; however, there was no clinically meaningful effect of age on raltegravir pharmacokinetics over the age range studied (19 to 71 years, with few (8) subjects over the age of 65).
Slovenian: Farmakokinetika lamivudina po uporabi pri bolnikih, starejših od 65 let, ni raziskana, vendar med bolniki v preiskovanih starostnih skupinah (od 19 do 71 let, z manjšim številom oseb (8), starejših od 65 let) starost ni imela klinično pomembnega vpliva na farmakokinetiko raltegravirja.
English: Baseline Characteristics and Efficacy Outcomes at Weeks 24 and 48 from IMPAACT P1066
Slovenian: Izhodiščne značilnosti in izidi učinkovitosti v 24. in 48. tednu v študiji IMPAACT P1066 (od 2 do 18 let starosti)
English: Lamivudine has been widely used as a component of antiretroviral combination therapy with other antiretroviral agents of the same class (NRTIs) or different classes (PIs, non-nucleoside reverse transcriptase inhibitors, integrase inhibitors).
Slovenian: Lamivudin se široko uporablja kot komponenta protiretrovirusnega kombiniranega zdravljenja z drugimi protiretrovirusnimi zdravili iz iste skupine (NRTI) ali iz drugih skupin (zaviralci proteaz, nenukleozidni zaviralci reverzne transkriptaze, zaviralci integraze).
English: Any child exposed in utero to nucleoside and nucleotide reverse transcriptase inhibitors, even HIV-negative children, should have clinical and laboratory follow-up and should be fully investigated for possible mitochondrial dysfunction in case of relevant signs or symptoms.
Slovenian: Vsakega otroka, tudi če je HIV-negativen, ki je in utero izpostavljen nukleozidnim ali nukleotidnim zaviralcem reverzne transkriptaze, je treba klinično in laboratorijsko spremljati ter ga v primeru relevantnih znakov ali simptomov temeljito preiskati glede možnega motenega delovanja mitohondrijev.