FrancophonIA/ELRC3.0 huggingface dataset:
English: • medicines changing the salt concentrations in your body (causing a so-called electrolyte imbalance),
Slovenian: • zdravila, ki spreminjajo koncentracije soli v telesu (povzročajo t.i. elektrolitsko neravnovesje),
English: Your doctor will need to check your blood sugar regularly since it may be increased by this medicine.
Slovenian: Zdravnik bo moral redno preverjati krvni sladkor, saj se lahko ta zaradi zdravila zviša.
English: • diabetes or risk factors for diabetes (e.g. obesity, or someone else in your family has diabetes).
Slovenian: • sladkorno bolezen ali dejavnike tveganja za sladkorno bolezen (npr. debelost ali ima nekdo drug v vaši družini sladkorno bolezen).
English: During treatment you may experience these serious side effects that require urgent medical attention.
Slovenian: Med zdravljenjem se lahko pojavijo ti resni neželeni učinki, ki zahtevajo nujno zdravniško pomoč.
English: Suicidality
Slovenian: Samomorilnost
English: Pharmacotherapeutic group: Psycholeptics, other antipsychotics, ATC code N05AX16
Slovenian: Farmakoterapevtska skupina: Psiholeptiki, drugi antipsihotiki, oznaka ATC N05AX16 Mehanizem delovanja
English: • higher blood pressure,
Slovenian: • zvišan krvni tlak,
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redkimi dednimi težavami intolerance galaktoze, popolnim pomanjkanjem laktaze ali malabsorpcijo glukoze-galaktoze, ne smejo jemati tega zdravila.
English: In long-term, open-label trials, TEAEs related to suicidality were reported for 23 subjects (1.6 %).
Slovenian: V dolgoročnih odprtih preskušanjih so o TEAE, povezanih s samomorilnostjo, poročali pri 23 preiskovancih (1,6 %).
English: Do not throw away any medicines via wastewater or household waste.
Slovenian: Zdravila ne smete zavreči v odpadne vode ali med gospodinjske odpadke.
English: Genotoxicity, carcinogenicity
Slovenian: Genotoksičnost, rakotvornost
English: Patients with a prior history of impulse-control disorders may be at increased risk and should be monitored carefully.
Slovenian: Bolniki z anamnezo motenj nadzora impulzov so lahko podvrženi večjemu tveganju in jih je treba pazljivo spremljati.
English: Tell your doctor immediately if you
Slovenian: Takoj obvestite zdravnika, če
English: • allergic reaction (e.g. swelling in the mouth, tongue, face and throat, itching, hives),
Slovenian: • alergijska reakcija (npr. oteklina v ustih, jeziku, obrazu in grlu, srbenje, koprivnica),
English: Risk factors that may predispose patients to severe complications include obesity and family history of diabetes.
Slovenian: Dejavniki tveganja, ki lahko bolnikom povečajo nagnjenost k hudim zapletom, vključujejo debelost in družinsko anamnezo sladkorne bolezni.
English: However, your doctor may prescribe a lower or higher dose to a maximum of 4 mg once a day.
Slovenian: Zdravnik vam lahko predpiše tudi manjši ali večji odmerek, do največ 4 mg enkrat na dan.
English: Fasting plasma glucose should be assessed before or soon after the initiation of the antipsychotic treatment.
Slovenian: Glukozo v plazmi na tešče (FPG - fasting plasma glucose) je treba oceniti pred začetkom ali kmalu po začetku zdravljenja z antipsihotiki.
English: Factors
Slovenian: Dejavniki
English: • a history of blood clots, or if someone else in your family has a history of blood clots, as medicines for schizophrenia have been associated with formation of blood clots.
Slovenian: • zdravstveno zgodovino krvnih strdkov ali če ima kdo v družini zdravstveno zgodovino krvnih strdkov, saj so bila zdravila za shizofrenijo povezana z nastankom krvnih strdkov.
English: Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome.
Slovenian: Čeprav je razširjenost sindroma največja med starejšimi, zlasti starejšimi ženskami, se ni mogoče zanašati na ocene razširjenosti, da bi ob začetku zdravljenja z antipsihotiki napovedali, pri katerih bolnikih obstaja verjetnost, da se bo razvili sindrom.
English: Consequently, new-borns should be monitored carefully.
Slovenian: Zato je treba novorojenčke skrbno spremljati.
English: • or had heart problems or a history of stroke, especially if you know that you have other risks factors for stroke.
Slovenian: • ali ste imeli težave s srcem ali imate možgansko kap v zdravstveni zgodovini, zlasti če veste, da imate druge dejavnike tveganja za pojav možganske kapi.
English: They may be caused by an abnormal muscle breakdown which can be life threatening and lead to kidney problems (a condition called rhabdomyolysis),
Slovenian: Lahko jih povzroči nenormalna razgradnja mišic, ki lahko ogroža življenje in povzroči težave z ledvicami (stanje, imenovano rabdomioliza),
English: Because patients may not recognise these behaviours as abnormal, it is important for prescribers to ask patients or their caregivers specifically about the development of new or increased impulse-control disorders or other compulsive behaviours while being treated with brexpiprazole.
Slovenian: Ker bolniki morda tega vedenja ne prepoznavajo kot nenormalnega, je pomembno, da zdravniki, ki zdravilo predpisujejo, bolnike ali njihove negovalce povprašajo zlasti po razvoju novih ali povečanih motenj nadzora impulzov ali motenj drugih kompulzivnih vedenj v času zdravljenja z brekspiprazolom.
English: If your baby has any of these symptoms you should contact your doctor.
Slovenian: Če ima vaš otrok katerega od teh simptomov, se obrnite na zdravnika.
English: These can be the signs of the so-called neuroleptic malignant syndrome (it is not known how many people are affected).
Slovenian: To so lahko znaki tako imenovanega nevroleptičnega malignega sindroma (ni znano, pri koliko bolnikih se lahko pojavijo).
English: People with this condition may also feel depressed, guilty, anxious or tense.
Slovenian: Bolniki s temi simptomi se lahko počutijo tudi depresivno, imajo občutek krivde, so tesnobni ali napeti.
English: Body temperature
Slovenian: Telesna temperatura
English: Population PK evaluation identified gender as statistically significant covariate.
Slovenian: Spol Populacijska farmakokinetična analiza je opredelila spol kot statistično pomembno sospremenljivko.
English: The volume of distribution of brexpiprazole following intravenous administration is high (1.56 L/kg ± 0.418 L/kg), indicating extravascular distribution.
Slovenian: Volumen porazdelitve brekspiprazola po intravenskem dajanju je visok (1,56 l/kg ± 0,418 l/kg), kar kaže na ekstravaskularno porazdelitev.
English: DK 2500 Valby Denmark
Slovenian: DK 2500 Valby Danska
English: While taking RXULTI you should avoid getting over-heated or dehydrated.
Slovenian: Med jemanjem zdravila RXULTI se morate izogibati pregrevanju ali dehidraciji.
English: Other urges, reported, include: compulsive sexual behaviours, compulsive shopping, binge eating, and other impulsive and compulsive behaviours.
Slovenian: Druge težnje, o katerih so poročali, vključujejo: kompulzivno spolno vedenje, kompulzivno nakupovanje, prenajedanje in druge oblike impulzivnega in kompulzivnega vedenja.
English: LS mean differencea, b (95 % CI)
Slovenian: LS povprečna razlikaa, b (95-% IZ)
English: All ADRs are listed by system organ class (SOC) and frequency: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data).
Slovenian: Vsi neželeni učinki zdravila so našteti po organskih sistemih (OS) in pogostnosti: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000) in neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov).
English: RXULTI is indicated for the treatment of schizophrenia in adult patients.
Slovenian: Zdravilo RXULTI je indicirano za zdravljenje shizofrenije pri odraslih bolnikih.
English: Do not use this medicine after the expiry date, which is stated on the blister and on the outer carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu in škatli poleg oznake »EXP«.
English: If a patient develops signs and symptoms indicative of NMS, or presents with unexplained high fever without additional clinical manifestations of NMS brexpiprazole must be discontinued immediately.
Slovenian: Če bolnik razvije znake in simptome, ki kažejo na NMS, ali pa ima nepojasnjeno visoko telesno temperaturo brez dodatnih kliničnih znakov NMS, je treba takoj prekiniti zdravljenje z brekspiprazolom.
English: Babies of mothers who take this medicine during the last three months of their pregnancy may show the following symptoms: shaking, muscle stiffness and/or muscle weakness, sleepiness, restlessness, breathing problems and difficulty in feeding.
Slovenian: Dojenčki mater, ki so jemale to zdravilo v zadnjih treh mesecih nosečnosti, imajo lahko naslednje simptome: tresenje, togost mišic in/ali mišična šibkost, zaspanost, nemir, težave z dihanjem in težave pri hranjenju.
English: Effects on QT
Slovenian: Učinke na interval QT
English: This medicine must not be taken by children and adolescents under 18 years of age.
Slovenian: Otroci in mladostniki, mlajši od 18 let, tega zdravila ne smejo jemati.
English: RXULTI with food and alcohol
Slovenian: Zdravilo RXULTI skupaj s hrano in alkoholom
English: These symptoms can temporally deteriorate or can even arise after discontinuation of treatment.
Slovenian: Ti simptomi se po prekinitvi zdravljenja lahko začasno poslabšajo ali se celo pojavijo.
English: Brexpiprazole is very persistent and very bioaccumulative but not toxic, to the environment: possible enrichment of brexpiprazole in terrestrial food chains might pose a concern (see section 6.6).
Slovenian: Brekspiprazol je zelo obstojen in zelo bioakumulativen, vendar ni strupen za okolje: možnost obogatitve kopenskih prehranjevalnih verig z breksipiprazolom bi lahko predstavljala tveganje (glejte poglavje 6.6).
English: Compulsive behaviours may result in harm to the patient and others if not recognised.
Slovenian: Če jih ne prepoznamo, lahko kompulzivna vedenja škodijo bolniku in drugim.
English: • medicines known to prolong your QT interval (an important measurement of your heart function in an electrocardiogram [ECG]),
Slovenian: • zdravila, za katera je znano, da podaljšajo interval QT (pomembna meritev srčne funkcije z elektrokardiogramom [EKG]),
English: If you are of childbearing age, you should use effective contraception while taking RXULTI.
Slovenian: Če ste ženska v rodni dobi, morate med zdravljenjem z zdravilom RXULTI uporabljati učinkovito kontracepcijo.
English: Administer a quarter of the recommended dose
Slovenian: Dajte četrtino priporočenega odmerka
English: The European Medicines Agency has deferred the obligation to submit the results of efficacy and safety studies with brexpiprazole in the paediatric population from 13 years to less than 18 years of age (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študije varnosti in učinkovitosti brekspiprazola pri pediatrični populaciji v starosti od 13 do manj kot 18 let (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Your doctor will regularly measure the white blood cells in your blood to minimise the risk for diseases called leukopenia, neutropenia and agranulocytosis.
Slovenian: Zdravnik bo redno meril število belih krvnih celic v krvi, da bi zmanjšal tveganje za bolezni, kot so levkopenija, nevtropenija in agranulocitoza.
English: The exposure (AUC) of brexpiprazole in women was estimated to be 25 % higher than in men (see section 4.8).
Slovenian: Ocenjena izpostavljenost (AUC) brekspiprazolu pri ženskah je bila za 25 % višja kot pri moških (glejte poglavje 4.8).
English: Brexpiprazole should be used cautiously in patients at risk for aspiration pneumonia.
Slovenian: Brekspiprazol je treba uporabljati previdno pri bolnikih s tveganjem za aspiracijsko pljučnico.
English: • from day 8 onwards take one film-coated tablet of the strength prescribed by your doctor each day.
Slovenian: • od 8. dne naprej vsak dan vzemite eno filmsko obloženo tableto ustrezne jakosti, ki vam jo predpiše zdravnik.
English: • ever experienced or start to experience restlessness and inability to sit still.
Slovenian: • ste doživeli ali začenjate doživljati nemir in ne morete sedeti pri miru.
English: Administer half of the recommended dose
Slovenian: Dajte polovico priporočenega odmerka
English: • thoughts or feelings about hurting yourself or to commit suicide or a suicide attempt (uncommon side effect - may affect up to 1 in 100 people).
Slovenian: • misli ali občutke, da bi se želeli samopoškodovati ali storiti samomor ali poskus samomora (občasni neželeni učinki, lahko se pojavijo pri največ 1 od 100 bolnikov).
English: At week 52 brexpiprazole (13.5 %) reduced the risk of impending relapse by 71 % compared with placebo (38.5 %).
Slovenian: Brekspiprazol (13,5 %) je v 52. tednu zmanjšal tveganje za pojav ponovitve za 71 % v primerjavi s placebom (38,5 %).
English: Extrapyramidal symptoms (including acute dystonia) are known class effects for antipsychotics.
Slovenian: Ekstrapiramidni simptomi (vključno z akutno distonijo) so znani učinki skupine antipsihotikov.
English: Other side effects (it is not known how many people are affected):
Slovenian: Drugi stranski učinki (ni znano, pri koliko bolnikih so se pojavili).
English: At steady-state, DM-3411 represents 23.1 % to 47.7 % of brexpiprazole exposure (AUC) in plasma.
Slovenian: V stanju dinamičnega ravnovesja DM-3411 predstavlja od 23,1 do 47,7 % izpostavljenosti brekspiprazolu (AUC) v plazmi.
English: Brexpiprazole does not affect absorption of medicinal products that are substrates of Breast Cancer Resistance Protein transporter (BCRP) and P-glycoprotein (P-gp) transporter.
Slovenian: Brekspiprazol ne vpliva na absorpcijo zdravil, ki so substrati prenašalca proteina odpornosti pri raku dojke (BCRP - breast cancer resistance protein) in prenašalca P-glikoproteina (Pgp).
English: Treatment group n
Slovenian: Skupina zdravljenih bolnikov n
English: The incidence of akathisia in the short-term, controlled trials (5.4 %) was similar to the incidence in the long-term, open-label trials (5.7 %).
Slovenian: Incidenca akatizije v kratkoročnih nadzorovanih preskušanjih (5,4 %) je bila podobna tisti pri dolgoročnih odprtih preskušanjih (5,7 %).
English: If you have taken more RXULTI than your prescribed dose, contact your doctor or your local hospital immediately.
Slovenian: Če ste vzeli večji odmerek zdravila RXULTI od predpisanega odmerka, takoj obvestite svojega zdravnika ali lokalno bolnišnico.
English: The maximum recommended daily dose is 4 mg.
Slovenian: Največji priporočeni dnevni odmerek je 4 mg.
English: RXULTI can be taken with or without food.
Slovenian: Zdravilo RXULTI lahko vzamete s hrano ali brez nje.
English: Patients with neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur.
Slovenian: Bolnike z nevtropenijo je treba skrbno spremljati glede pojava zvišane telesne temperature ali drugih simptomov ali znakov okužbe in jih takoj, ko se pojavijo simptomi ali znaki, zdraviti.
English: les Bouillides Sophia Antipolis 06560 Valbonne France
Slovenian: les Bouillides Sophia Antipolis 06560 Valbonne Francija
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from brexpiprazole therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba med prenehanjem dojenja in prenehanjem/prekinitvijo zdravljenja z brekspiprazolom, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
English: Due to the testing hierarchy the greater improvement shown for both 2 mg/day and 4 mg/day on the CGI-S can only be considered supportive for trials 2, 3 and 4 (see table 3).
Slovenian: Zaradi hierarhije testiranja se lahko večje izboljšanje CGI-S pri 2 in 4 mg/dan smatra le kot podporen podatek za preskušanja 2, 3 in 4 (glejte preglednico 3).
English: After single and multiple once daily dose administration, brexpiprazole exposure (Cmax and AUC) increase in proportion to the dose administered.
Slovenian: Po enkratnem in večkratnih odmerkih enkrat dnevno se izpostavljenost brekspiprazolu (Cmax in AUC) poveča sorazmerno z odmerkom.
English: This medicine may cause significant weight gain which may affect your health.
Slovenian: Povečanje telesne mase To zdravilo lahko povzroči pomembno povečanje telesne mase, kar lahko vpliva na vaše zdravje.
English: Overall in the brexpiprazole clinical development program for schizophrenia, one death due to suicide, considered not drug related by the investigator, occurred.
Slovenian: Skupaj je v kliničnem razvojnem programu zdravljenja shizofrenije z brekspiprazolom prišlo do ene smrti zaradi samomora, za katerega je raziskovalec menil, da ni povezan z jemanjem zdravila.
English: • for the first 4 days take one 1 mg film-coated tablet per day,
Slovenian: • v prvih 4 dneh vzemite eno 1-mg filmsko obloženo tableto na dan,
English: Although no specific pharmacokinetic study was conducted, population pharmacokinetic evaluation revealed no evidence of clinically significant race-related differences in the pharmacokinetics of brexpiprazole.
Slovenian: Čeprav ni bilo opravljene specifične farmakokinetične študije, farmakokinetična ocena populacije ni pokazala nobenih klinično pomembnih razlik v farmakokinetiki brekspiprazola med bolniki različnih ras.
English: RXULTI contains the active substance brexpiprazole, which belongs to a group of medicines called antipsychotics.
Slovenian: Zdravilo RXULTI vsebuje učinkovino brekspiprazol, ki spada v skupino zdravil, imenovanih antipsihotiki.
English: After single dose administration of brexpiprazole (2 mg), elderly subjects (older than 65 years) exhibited similar brexpiprazole systemic exposure (Cmax and AUC) in comparison with the adult subjects (18 years to 45 years old; see sections 4.2 and 4.4).
Slovenian: Po dajanju enkratnega odmerka brekspiprazola (2 mg) so starejši bolniki (starejši od 65 let) izkazali podobno sistemsko izpostavljenost brekspiprazolu (Cmax in AUC) v primerjavi z odraslimi osebami (od 18 do 45 let, glejte poglavji 4.2 in 4.4).
English: Administration of a 4 mg brexpiprazole tablet with a standard high fat meal did not significantly affect the Cmax or AUC of brexpiprazole.
Slovenian: Uporaba 4-mg tablete brekspiprazola s standardnim obrokom z visoko vsebnostjo maščob ni pomembno vplivala na Cmax ali AUC brekspiprazola.
English: An electrocardiogram should be obtained in case of overdose and if QT interval prolongation is present, cardiac monitoring should be instituted.
Slovenian: Pri prevelikem odmerjanju je treba pridobiti elektrokardiogram in če je prisotno podaljšanje intervala QT, je treba začeti spremljati delovanje srca.
English: Patients treated with any antipsychotics, including brexpiprazole, should be observed for signs and symptoms of hyperglycaemia (such as polydipsia, polyuria, polyphagia and weakness).
Slovenian: Bolnike, ki se zdravijo s katerim koli antipsihotikom, vključno z brekspiprazolom, je treba opazovati glede znakov in simptomov hiperglikemije (kot so polidipsija, poliurija, polifagija in šibkost).
English: (Ki: 0.1 nM to 0.5 nM).
Slovenian: 0,2 do 0,6 nM).
English: In the primary analysis of time to impending relapse patients on brexpiprazole showed a significantly longer time to relapse compared with patients on placebo (p < 0.0001).
Slovenian: Primarna analiza časa do morebitne ponovitve bolezni je pokazala, da so bolniki na brekspiprazolu imeli znatno daljši čas do ponovitve v primerjavi z bolniki, ki so prejemali placebo (p < 0,0001).
English: • medicines increasing an enzyme called creatine phosphokinase (CPK),
Slovenian: • zdravila, ki zvišujejo ravni encima, imenovanega kreatin fosfokinaza (CPK),
English: These improvements were maintained during the 52-week double-blind maintenance phase in patients on brexpiprazole whereas patients randomised to placebo showed deterioration in PANSS, CGI-S and CGI-I, and GAF scores [ANCOVA LOCF]).
Slovenian: Te izboljšave so se v 52-tedenski dvojno slepi vzdrževalni fazi pri bolnikih na brekspiprazolu ohranile, medtem ko so bolniki, randomizirani v skupino s placebom, izkazali poslabšanje rezultata po lestvicah PANSS, CGI-S ter CGI-I in GAF [ANCOVA LOCF]).
English: What RXULTI is and what it is used for
Slovenian: Kaj je zdravilo RXULTI in za kaj ga uporabljamo
English: • symptoms related to blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing (uncommon side effect - may affect up to 1 in 100 people).
Slovenian: • simptomi, povezani s krvnimi strdki v žilah, zlasti v nogah (simptomi vključujejo oteklost, bolečino in pordelost nog), ki lahko potujejo po krvnih žilah v pljuča, kjer povzročijo bolečino v prsih in težave z dihanjem (občasni neželeni učinki, lahko se pojavijo pri največ 1 od
English: RXULTI can help to keep the symptoms under control and to prevent relapse as you continue treatment.
Slovenian: Zdravilo RXULTI lahko pomaga nadzorovati simptome in pri nadaljevanju zdravljenja preprečiti ponovitve.
English: During long term treatment the plasma glucose levels should be monitored regularly for worsening of glucose control.
Slovenian: Med dolgotrajnim zdravljenjem je treba redno spremljati koncentracijo glukoze v plazmi glede poslabšanja njene urejenosti.
English: • ever inhaled food, stomach acid, or saliva into your lungs causing a disease called aspiration pneumonia.
Slovenian: • težave z vdihavanjem hrane, želodčne kisline ali sline v pljuča, ki povzročajo bolezen, ki jo imenujemo aspiracijska pljučnica.
English: Patients with severe neutropenia (absolute neutrophil count < 1,000/mm3) should discontinue brexpiprazole and have their WBC followed until recovery.
Slovenian: Pri bolnikih s hudo nevtropenijo (absolutno število nevtrofilcev < 1.000/mm3) je treba prenehati z uporabo brekspiprazola in njihovo število WBC spremljati do okrevanja.
English: If you miss two or more doses, contact your doctor.
Slovenian: Če ste pozabili vzeti dva ali več odmerkov, se posvetujte z zdravnikom.
English: Thereafter, if according to clinical response, further dose adjustments are required, the dose may be increased up to a maximum of three times the recommended daily dose.
Slovenian: V skladu s kliničnim odzivom bo odmerek nato morda treba dodatno prilagoditi s povečanjem do največ trikratnega priporočenega dnevnega odmerka.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of brexpiprazole/ metabolites in milk of rats (see section 5.3).
Slovenian: Razpoložljivi farmakodinamični/toksikološki podatki pri živalih kažejo na izločanje brekspiprazola/presnovkov v mleko podgan (glejte poglavje 5.3).
English: Possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell count (WBC) and history of drug-induced leukopenia/neutropenia.
Slovenian: Možni dejavniki tveganja za levkopenijo/nevtropenijo vključujejo že obstoječe nizko število belih krvnih celic (WBC - white blood cells) in anamnezo z zdravili povzročene levkopenije/nevtropenije.
English: There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder.
Slovenian: Poročali so o agitaciji, hipertoniji, hipotoniji, tremorju, zaspanosti, respiratorni stiski in motnjah hranjenja.