FrancophonIA/ELRC3.0 huggingface dataset:
English: • Hold the syringe in one hand and with the other hand slide the outer protective shield over the exposed needle until it locks in place
Croatian: • Jednom rukom držite štrcaljku, a drugom nataknite vanjsku zaštitu preko igle tako da sjedne na svoje mjesto.
English: Week 12 results showed statistically significant improvement of the signs and symptoms of active nr-axSpA in patients treated with Humira compared to placebo (Table 14).
Croatian: Rezultati u 12. tjednu pokazali su statistički značajno poboljšanje znakova i simptoma aktivnog nr-axSpA u bolesnika koji su liječeni lijekom Humira u odnosu na placebo (Tablica 14).
English: In patients who develop HBV reactivation, Humira should be stopped and effective anti-viral therapy with appropriate supportive treatment should be initiated.
Croatian: U bolesnika u kojih se javi reaktivacija HBV infekcije mora se prekinuti terapija lijekom Humira i započeti učinkovita antivirusna terapija uz odgovarajuće potporno liječenje.
English: Your doctor will decide if Humira should be used with methotrexate or alone.
Croatian: Vaš će liječnik odlučiti hoće li se Humira primjenjivati s metotreksatom ili sama.
English: • impotence
Croatian: • impotencija
English: Consequently, Humira can be used during breastfeeding.
Croatian: Stoga se Humira može primjenjivati tijekom dojenja.
English: Luxembourg/Luxemburg AbbVie SA
Croatian: Luxembourg/Luxemburg
English: Humira/methotrexate combination therapy was clinically and statistically superior to methotrexate (p < 0.001) and Humira monotherapy (p < 0.001) in achieving a low disease state in patients with recently diagnosed moderate to severe rheumatoid arthritis.
Croatian: Kombinirana primjena lijeka Humira i metotreksata pokazala se klinički i statistički superiornom monoterapiji metotreksatom (p <0,001) i lijekom Humira (p <0,001) u postizanju niske aktivnosti bolesti u bolesnika s nedavno dijagnosticiranim umjerenim do teškim reumatoidnim artritisom.
English: Your doctor may tell you to stop using Humira for some time.
Croatian: Vaš liječnik Vam može reći da neko vrijeme prestanete primjenjivati lijek Humira.
English: A single Humira pre-filled syringe may be stored at temperatures up to a maximum of 25°C for a period of up to 14 days.
Croatian: Jedna napunjena štrcaljka lijeka Humira može se čuvati na temperaturama do maksimalno 25°C u trajanju do 14 dana.
English: Concomitant administration of adalimumab with other biologic DMARDS (e.g, anakinra and abatacept) or other TNF-antagonists is not recommended based upon the possible increased risk for infections, including serious infections and other potential pharmacological interactions.
Croatian: anakinra i abatacept) ili drugih antagonista TNF-a se ne preporučuje zbog mogućeg povećanog rizika od razvoja infekcija, uključujući ozbiljne infekcije, i drugih potencijalnih farmakoloških interakcija
English: Patients subsequently underwent a mandatory taper schedule, with complete corticosteroid discontinuation by Week 19.
Croatian: Nakon toga je uslijedilo obavezno postupno smanjivanje doze i potpuni prestanak primjene kortikosteroida do 19. tjedna.
English: ASDAS Inactive Disease hs-CRP
Croatian: ASDAS neaktivna bolest hs-CRPd,f,g
English: Among patients who had failed prior anti-TNF treatment, Week 52 remission was achieved by 3% on placebo and 10% on adalimumab.
Croatian: Među bolesnicima koji nisu imali uspjeha s prethodnim liječenjem antagonistima TNF-a remisiju je u 52. tjednu postiglo 3% u skupini koja je primala placebo i 10% u skupini koja je primala adalimumab.
English: years.
Croatian: tjedana.
English: Humira is recommended for use in combination with methotrexate.
Croatian: Preporučuje se primjenjivati lijek Humira u kombinaciji s metotreksatom.
English: • ≥ 40 kg: 40 mg every week or 80 mg every other week
Croatian: • ≥ 40 kg: 40 mg svaki tjedan ili 80 mg svaki drugi tjedan
English: The syringe must be protected from light, and discarded if not used within the 14-day period.
Croatian: Štrcaljku se mora zaštiti od svjetlosti i zbrinuti ako se ne iskoristi unutar 14 dana.
English: Physicians should exercise caution when considering the use of Humira in patients with a history of recurring infection or with underlying conditions which may predispose patients to infections, including the use of concomitant immunosuppressive medications.
Croatian: Liječnici trebaju oprezno razmotriti liječenje lijekom Humira u bolesnika s ponavljajućim infekcijama u anamnezi ili podležećim stanjima koja pogoduju razvoju infekcija u bolesnika, uključujući istodobnu primjenu imunosupresivnih lijekova.
English: • Do not inject into skin that is sore, bruised, red, hard, scarred, has stretch marks, or areas with psoriasis plaques
Croatian: • Nemojte ubrizgavati u područja bolne kože, modrica, crvenila, tvrde kože, ožiljaka, strija ili područja s plak psorijazom
English: • Do not recycle or throw the pre-filled syringe in the household waste
Croatian: • Nemojte reciklirati niti bacati napunjenu štrcaljku u kućni otpad.
English: All patients received a 2-week standardised dose of prednisone 60 mg/day at study entry followed by a mandatory taper schedule, with complete corticosteroid discontinuation by Week 15.
Croatian: Svi su bolesnici pri uključivanju u ispitivanje 2 tjedna primali standardiziranu dozu prednizona od 60 mg/dan, nakon čega je uslijedilo obavezno postupno smanjivanje doze, uz potpuni prestanak primjene kortikosteroida do 15. tjedna.
English: Humira can be taken together with methotrexate or certain disease-modifying anti-rheumatic agents (sulfasalazine, hydroxychloroquine, leflunomide and injectable gold preparations), steroids or pain medications including non-steroidal anti-inflammatory drugs (NSAIDs).
Croatian: Humira se može primjenjivati istodobno s metotreksatom ili nekim antireumaticima koji mijenjaju tijek bolesti (sulfasalazinom, hidroksiklorokinom, leflunomidom i injekcijskim pripravcima zlata), steroidima ili lijekovima za ublažavanje boli, uključujući i nesteroidne protuupalne lijekove (NSAIL).
English: Of those in clinical response at Week 4, 48% had been previously exposed to other TNFantagonists.
Croatian: 48% bolesnika koji su imali klinički odgovor u 4. tjednu već je prije koristilo neki drugi antagonist TNF-a.
English: The primary endpoint in RA study V was the percent of patients who achieved an ACR 50 response at Week 52.
Croatian: Primarna mjera ishoda ispitivanja RA V bio je postotak bolesnika u kojih je postignut terapijski odgovor ACR 50 nakon 52 tjedna liječenja.
English: 673 patients with active nr-axSpA (mean baseline disease activity [BASDAI] was 7.0) who had an inadequate response to  2 NSAIDs, or an intolerance to or a contraindication for NSAIDs enrolled into the open-label period of Study nr-axSpA II during which they received Humira 40 mg eow for 28 weeks.
Croatian: 673 bolesnika s aktivnim nr-axSpA (srednja početna vrijednost aktivnosti bolesti [BASDAI] iznosila je 7,0) koja nisu imala zadovoljavajući odgovor na ≥ 2 NSAIL-a, nisu podnosila NSAIL-ove ili su imala kontraindikaciju za primjenu NSAIL-ova uključena su u otvoreno razdoblje ispitivanja nr-axSpA II, u kojem su primali lijek Humira u dozi od 40 mg svaka dva tjedna tijekom 28 tjedana.
English: In the pivotal controlled trials in adults and children, the rate of infection was 1.51 per patient year in the Humira treated patients and 1.46 per patient year in the placebo and active control-treated patients.
Croatian: U pivotalnim kontroliranim ispitivanjima u odraslih i djece, stopa infekcija bila je 1,51 po bolesnikgodini u bolesnika liječenih lijekom Humira, odnosno 1,46 po bolesnik-godini u bolesnika koji su primali placebo ili aktivni kontrolni lijek.
English: For the 2, 4 and 6 pre-filled pen packs, each pre-filled pen comes with 1 alcohol pad.
Croatian: Kod pakiranja od 2, 4 ili 6 napunjenih brizgalica, svaka napunjena brizgalica dolazi s 1 jastučićem natopljenim alkoholom.
English: Humira treated patients had significantly greater improvement at Week 12 which was maintained through Week 24 in both the SF36 and Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL).
Croatian: U bolesnika koji su primali lijek Humira zabilježeno je značajno veće poboljšanje kvalitete života u 12. tjednu, koje se održalo do 24. tjedna, prema upitniku SF36 i upitniku za ocjenu kvalitete života kod ankilozantnog spondilitisa (engl.
English: For patients who develop the signs and symptoms such as fever, malaise, weight loss, sweats, cough, dyspnoea, and/or pulmonary infiltrates or other serious systemic illness with or without concomitant shock an invasive fungal infection should be suspected and administration of Humira should be promptly discontinued.
Croatian: Ako se u bolesnika pojave znakovi i simptomi kao što su vrućica, malaksalost, gubitak težine, znojenje, kašalj, dispneja i/ili plućni infiltrati ili druge ozbiljne sistemske bolesti praćene istodobnim šokom ili bez njega, treba posumnjati na invazivnu gljivičnu infekciju te odmah prekinuti primjenu lijeka Humira.
English: DO NOT RECAP as this could cause the unit to discharge.
Croatian: NE VRAĆAJTE KAPICU jer bi moglo doći do izbacivanja.
English: In addition, no malignancies were observed in 192 paediatric patients with an exposure of 498.1 patient years during Humira trials in paediatric patients with Crohn's disease.
Croatian: Dodatno, nisu primijećene zloćudne bolesti u 192 pedijatrijska bolesnika s izloženošću od 498,1 bolesnik-godine u ispitivanjima lijeka Humira u pedijatrijskih bolesnika s Crohnovom bolešću.
English: D-65205 Wiesbaden Germany and
Croatian: D-65205 Wiesbaden
English: Your child may first be given other medicines.
Croatian: Vašem će djetetu možda prvo biti propisani drugi lijekovi.
English: In adult plaque psoriasis patients on long term adalimumab monotherapy who participated in a withdrawal and retreatment study, the rate of antibodies to adalimumab after retreatment (11 of 482 subjects, 2.3%) was similar to the rate observed prior to withdrawal (11 of 590 subjects, 1.9%).
Croatian: U odraslih bolesnika s plak psorijazom koji su dugoročno liječeni adalimumabom u monoterapiji i koji su sudjelovali u ispitivanju ukidanja i ponovnog uvođenja terapije, stopa protutijela na adalimumab nakon ponovnog uvođenja terapije (11 od 482 ispitanika, 2,3%) bila je slična stopi opaženoj prije ukidanja terapije (11 od 590 ispitanika, 1,9%).
English: Radiographs of hands, wrists, and feet were obtained at baseline and Week 24 during the double-blind period when patients were on Humira or placebo and at Week 48 when all patients were on open-label Humira.
Croatian: Zglobovi šaka, zapešća i stopala radiološki su snimljeni na početku ispitivanja, u 24. tjednu tijekom dvostruko slijepog dijela ispitivanja, kada su bolesnici primali lijek Humira ili placebo, te u 48. tjednu ispitivanja, kada su svi bolesnici otvoreno primali lijek Humira.
English: • mood swings (including depression)
Croatian: • promjene raspoloženja (uključujući depresiju)
English: 2-sided P value from log rank test. NE = not estimable.
Croatian: Dvostrana P-vrijednost iz log rang testa.
English: • bacterial infections
Croatian: • bakterijske infekcije
English: • difficulty sleeping
Croatian: • otežano spavanje
English: Similar remission rates were observed for the 160/80 mg and 80/40 mg induction regimens by Week 8 and adverse events were more frequently noted in the 160/80 mg group.
Croatian: U skupinama koje su primale indukcijske režime od 160/80 mg i 80/40 mg uočene su slične stope remisije do 8. tjedna, dok su štetni događaji zabilježeni češće u skupini koja je primala lijek Humira 160/80 mg.
English: Figure 1: Kaplan-Meier Curves Summarizing Time to Treatment Failure on or after Week 6 (Study UV I) or Week 2 (Study UV II)
Croatian: Slika 1: Kaplan-Meierove krivulje koje sažeto prikazuju vrijeme do neuspjeha liječenja u 6. tjednu ili nakon njega (ispitivanje UV I) odnosno u 2. tjednu ili nakon njega (ispitivanje UV II)
English: • moderate to severe Crohn's disease in adults and
Croatian: • umjerene do teške Crohnove bolesti u odraslih i
English: All doses/schedules of Humira in all four studies showed statistically significantly greater improvement in the disability index of the HAQ from baseline to Month 6 compared to placebo and in RA study III the same was seen at Week 52.
Croatian: U sva je četiri ispitivanja pri svim dozama/režimima davanja lijeka Humira zabilježeno statistički značajno veće poboljšanje indeksa onesposobljenosti HAQ od početka ispitivanja do 6. mjeseca nego kod placeba, a u ispitivanju RA III isto je primijećeno i u 52. tjednu.
English: STEP 1
Croatian: KORAK 1
English: The Humira pre-filled pen is available in packs containing 1, 2, 4 and 6 pre-filled pens.
Croatian: Napunjena brizgalica lijeka Humira je dostupna u pakiranjima od 1, 2, 4 ili 6 napunjenih brizgalica.
English: autoantibody test positive (including double stranded DNA antibody),
Croatian: pozitivan nalaz testa na autoprotutijela (uključujući protutijela na dvolančanu DNK),
English: • If your child has moderate or severe heart failure.
Croatian: • Ako Vaše dijete boluje od umjerenog ili teškog zatajenja srca.
English: After 16weeks of therapy, patients who achieved at least a PASI 75 response (PASI score improvement of at least 75% relative to baseline), entered period B and received open-label 40 mg Humira every other week.
Croatian: Nakon 16 tjedana terapije, bolesnici u kojih je postignut barem odgovor PASI 75 (poboljšanje PASI rezultata za barem 75% u odnosu na početak terapije) ušli su u razdoblje B (otvoreni dio ispitivanja) i primali po 40 mg lijeka Humira svaki drugi tjedan.
English: Among patients who were not in response at Week 4, 43% of Humira maintenance patients responded by Week 12 compared to 30% of placebo maintenance patients.
Croatian: Među bolesnicima koji u 4. tjednu nisu imali odgovor, 43% bolesnika koji su primali dozu održavanja lijeka Humira imalo je klinički odgovor do 12. tjedna u odnosu na 30% u skupini bolesnika koji su uzimali placebo kao terapiju održavanja.
English: Psoriasis Study IV compared efficacy and safety of Humira versus placebo in 217 adult patients with moderate to severe nail psoriasis.
Croatian: U ispitivanju Psoriasis Study IV uspoređivale su se djelotvornost i sigurnost lijeka Humira u odnosu na placebo u 217 odraslih bolesnika s umjerenom do teškom psorijazom noktiju.
English: This risk may increase if your child has problems with his/her lungs.
Croatian: Taj rizik može biti povećan ako dijete ima tegobe s plućima.
English: A total of 76.5% (218/285) of patients who entered the retreatment period had a response of PGA “clear” or “minimal” after 16 weeks of retreatment, irrespective of whether they relapsed during withdrawal (69.1%[123/178] and 88.8% [95/107] for patients who relapsed and who did not relapse during the withdrawal period, respectively).
Croatian: Ukupno je 76,5% (218/285) bolesnika kojima je liječenje ponovno uvedeno imalo PGA odgovor “bez bolesti” ili “minimalno” nakon 16 tjedana ponovnog liječenja, bez obzira na to jesu li doživjeli relaps u razdoblju kada je liječenje bilo ukinuto (69,1% [123/178] za bolesnike s relapsom odnosno 88,8% [95/107] za bolesnike bez relapsa u razdoblju kada je liječenje bilo ukinuto).
English: Do not put either of the caps back on the pre-filled pen.
Croatian: Ne vraćajte niti jednu od kapica natrag na brizgalicu.
English: STEP 8
Croatian: KORAK 8
English: • severe allergic reaction with shock
Croatian: • teška alergijska reakcija uz šok
English: Overall responses were generally better and, fewer patients developed antibodies when treated with the combination of Humira and MTX compared to Humira alone.
Croatian: Ukupni odgovori uglavnom su bili bolji i manje je bolesnika razvilo protutijela uz kombiniranu terapiju lijekom Humira i metotreksatom nego uz monoterapiju lijekom Humira.
English: 3) Choosing and preparing an injection site
Croatian: 3) Odabir i priprema mjesta za ubrizgavanje
English: • lupus-like syndrome
Croatian: • sindrom sličan lupusu
English: • It is important that you tell your baby's doctors and other health care professionals about your Humira use during your pregnancy before the baby receives any vaccine (for more information on vaccines see the “Warnings and precautions” section).
Croatian: • Važno je da prije bilo kakvog cijepljenja djeteta obavijestite liječnika svog djeteta i druge zdravstvene radnike o tome da ste u trudnoći primali lijek Humira (za više informacija o cjepivima pogledajte dio „Upozorenja i mjere opreza“).
English: The symptoms described above can be signs of the below listed side effects, which have been observed with Humira.
Croatian: Gore opisani simptomi mogu biti znakovi dolje nabrojenih nuspojava, uočenih pri primjeni lijeka Humira.
English: MTX = methotrexate P=0.027, Humira 0.8 mg/kg versus MTX P=0.083, Humira 0.8 mg/kg versus MTX
Croatian: PGA: bez bolesti/minimalnoc a MTX = metotreksat b P=0,027, Humira 0,8 mg/kg naspram MTX-a c P=0,083, Humira 0,8 mg/kg naspram MTX-a
English: • cancer that affects the lymph system
Croatian: • rak koji zahvaća limfni sustav
English: The most commonly reported adverse reactions are infections (such as nasopharyngitis, upper respiratory tract infection and sinusitis), injection site reactions (erythema, itching, haemorrhage, pain or swelling), headache and musculoskeletal pain.
Croatian: Najčešće prijavljene nuspojave su infekcije (kao što su nazofaringitis, infekcija gornjih dišnih putova i sinusitis), reakcije na mjestu primjene (eritem, svrbež, krvarenje, bol ili oticanje), glavobolja i bol u mišićno-koštanom sustavu.
English: Melanoma and Merkel cell carcinoma have also been reported in patients treated with TNF-antagonists including adalimumab (see section 4.8).
Croatian: Melanom i karcinom Merkelovih stanica su također prijavljeni u bolesnika liječenih antagonistima TNF-a, uključujući adalimumab
English: • elevated liver enzymes.
Croatian: • povišena razina jetrenih enzima.
English: All patients should be advised to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias (e.g. persistent fever, bruising, bleeding, pallor) while on Humira.
Croatian: Bolesnike treba upozoriti da se odmah obrate liječniku ako se za vrijeme liječenja lijekom Humira pojave znakovi i simptomi koji upućuju na krvne diskrazije (npr. stalna vrućica, nastanak modrica, krvarenje, bljedilo).
English: If you stop using Humira
Croatian: Ako prestanete uzimati lijek Humira
English: By Week 68, patients receiving continuous Humira treatment showed statistically significant greater improvement of the signs and symptoms of active nr-axSpA as compared to patients allocated to treatment withdrawal during the double-blind period of the study (Table 15).
Croatian: Bolesnici koji su neprekidno primali lijek Humira su do 68. tjedna pokazali statistički značajno veće poboljšanje znakova i simptoma aktivnog nr-axSpA u usporedbi s bolesnicima kojima je terapija ukinuta tijekom dvostruko slijepog razdoblja ispitivanja (Tablica 15).
English: Check the appearance of the Humira solution through the window on the sides of the pre-filled pen.
Croatian: Provjerite izgled otopine lijeka Humira kroz prozorčić na napunjenoj brizgalici.
English: Humira is contraindicated in moderate to severe heart failure (see section 4.3).
Croatian: Primjena lijeka Humira je kontraindicirana u bolesnika s umjerenim do teškim zatajenjem srca (vidjeti dio 4.3).
English: Do not remove the needle cover until just before injection.
Croatian: Pokrov igle uklonite tek neposredno prije primjene.
English: Do not use the pre-filled syringe and call your doctor or pharmacist if the
Croatian: Nemojte primijeniti napunjenu brizgalicu i odmah se obratite liječniku ili ljekarniku ako je
English: Improvement in number of active joints with arthritis was maintained during the OL period through Week 156 for the 26 of 31 (84%) patients in the Humira group who remained in the study.
Croatian: Poboljšanje rezultata za broj aktivnih zglobova zahvaćenih artritisom održalo se tijekom otvorenog razdoblja kroz 156 tjedana ispitivanja za 26 od 31 (84%) bolesnika u skupini liječenoj lijekom Humira koji su ostali u ispitivanju.
English: No malignancies were observed in 249 paediatric patients with an exposure of 655.6 patient years during Humira trials in patients with juvenile idiopathic arthritis (polyarticular juvenile idiopathic arthritis and enthesitis-related arthritis).
Croatian: U 249 pedijatrijskih bolesnika s izloženošću od 655,6 bolesnik-godina tijekom ispitivanja lijeka Humira u bolesnika s juvenilnim idiopatskim artritisom (poliartikularnim juvenilnim idiopatskim artritisom i artritisom povezanim s entezitisom) nisu primijećene zloćudne bolesti.
English: The primary endpoint was the percent change from Baseline to Week 12 in the number of active joints with arthritis (swelling not due to deformity or joints with loss of motion plus pain and/or tenderness), which was achieved with mean percent decrease of62.6% (median percent change -88.9%) in patients in the Humira group compared to -11.6% (median percent change -50.0%) in patients in the placebo group.
Croatian: Primarna mjera ishoda bila je postotna promjena broja aktivnih zglobova zahvaćenih artritisom (oticanje koje nije posljedica deformacije ili zglobovi smanjene pokretljivosti uz bol i/ili osjetljivost) od početka ispitivanja do 12. tjedna, koja je postignuta uz srednji postotak smanjenja od -62,6% (medijan postotka promjene -88,9%) u bolesnika u skupini liječenoj lijekom Humira u usporedbi s -11,6% (medijan postotka promjene -50,0%) u bolesnika u skupini koja je primala placebo.
English: RA study II evaluated 544 patients with moderately to severely active rheumatoid arthritis who were  18 years old and had failed therapy with at least one disease-modifying, anti-rheumatic drugs.
Croatian: Ispitivanje RA II obuhvatilo je 544 bolesnika s umjereno teškim do teškim aktivnim reumatoidnim artritisom u dobi od 18 godina i starijih u kojih prethodna terapija barem jednim antireumatskim lijekom koji modificira tijek bolesti nije bila uspješna.
English: Your child should not take Humira with medicines containing the active substances anakinra or abatacept due to increased risk of serious infection.
Croatian: Vaše dijete ne smije primjenjivati lijek Humira s drugim lijekovima koji sadrže djelatne tvari anakinru ili abatacept zbog povećanog rizika od ozbiljne infekcije.
English: • Your belly (abdomen) at least 5 cm from your belly button (navel)
Croatian: • Trbuh (abdomen) barem 5 cm od pupka
English: When combining controlled portions of these trials and ongoing and completed open label extension studies with a median duration of approximately 3.3 years including 6,427 patients and over 26,439 patient-years of therapy, the observed rate of malignancies, other than lymphoma and nonmelanoma skin cancers is approximately 8.5 per 1,000 patient years.
Croatian: Kada se objedine rezultati kontroliranih dijelova tih ispitivanja te otvorenih produžetaka ispitivanja koji su u tijeku ili dovršeni, s ukupno 6427 bolesnika i više od 26 439 bolesnik-godina terapije te medijanom trajanja od 3,3 godine, primijećena stopa zloćudnih bolesti, isključujući limfome i nemelanomske tumore kože, iznosi približno 8,5 na 1000 bolesnik-godina.
English: The incidence of serious infections was 0.04 per patient year in Humira treated patients and 0.03 per patient year in placebo and active control − treated patients.
Croatian: Incidencija ozbiljnih infekcija bila je 0,04 po bolesnik-godini u bolesnika liječenih lijekom Humira, odnosno 0,03 po bolesnik-godini u onih koji su primali placebo ili aktivni kontrolni lijek.
English: Patients induced with 160/80 mg Humira achieved clinical remission versus placebo at Week 8 in statistically significantly greater percentages in study UC-I (18% vs. 9% respectively, p=0.031) and study UC-II (17% vs. 9% respectively, p=0.019).
Croatian: Bolesnici koji su primili indukciju lijekom Humira u dozi od 160/80 mg u osmom su tjednu postigli kliničku remisiju u značajno većem postotku u odnosu na placebo i u ispitivanju UC-I (18%, odnosno 9%, p=0,031) i u ispitivanju UC-II (17%, odnosno 9%, p=0,019).
English: Most ALT elevations occurred with concomitant methotrexate use.
Croatian: Većinom je povišenje razine ALT-a zabilježeno pri istodobnoj primjeni s metotreksatom.