FrancophonIA/ELRC3.0 huggingface dataset:
English: The plasma levels obtained after multiple doses are similar to those achieved after a single dose.
Slovenian: Vrednosti v plazmi po več odmerkih so podobni tistim po enem odmerku.
English: Tell your doctor immediately if you get any sudden wheeziness, difficulty in breathing, redness on the upper part of the body, rash or itching.
Slovenian: Nemudoma poiščite zdravniško pomoč, če opazite naslednje znake: piskajoče dihanje, oteženo dihanje, pordelost zgornjega dela telesa, izpuščaj ali srbečico.
English: Minimum inhibitory concentration (MIC) breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) are as follows:
Slovenian: Mejne vrednosti (MIK), ki temeljijo na testih Evropskega odbora za preskušanje za protimikrobne občutljivosti (EUCAST):
English: If a bullous disorder is suspected, the drug should be discontinued and specialised dermatological assessment should be carried out.
Slovenian: Pri sumu na bulozni dermatitis moramo takoj prekiniti zdravljenje in opraviti specializirano dermatološko oceno.
English: Vancomycin is poorly dialyzable by intermittent hemodialysis.
Slovenian: Vankomicin se med intermitentno hemodializo slabo dializira.
English: Tinnitus, possibly preceding onset of deafness, should be regarded as an indication to discontinue treatment.
Slovenian: Tinitus, ki se lahko pojavi pred izgubo sluha, je znak, da moramo zdravljenje prekiniti.
English: Alternative aetiologies should always be sought and Clostridium difficile enterocolitis be proven.
Slovenian: Vedno moramo iskati alternativne vzroke bolezni in dokazati enterokolitis, povezan z bakterijo Clostridium difficile.
English: Streptococcus groups A, B, C and G
Slovenian: Streprokoki skupin A, B, C in G ≤ 2 mg/l
English: Necrosis may occur after intramuscular injection.
Slovenian: Po intramuskularni injekciji lahko pride do nekroze.
English: Orientative dosing recommendations for the paediatric population are shown in table below that follow the same principles as in adult patients.
Slovenian: Orientacijske vrednosti za otroke so prikazane v spodnji preglednici in so izračunane po enakem sistemu kot za odrasle.
English: Interstitial nephritis, acute renal failure.
Slovenian: Redki intersticijski nefritis, akutna ledvična odpoved
English: Intermittent therapy: initial dose of 30 mg/kg in the long-dwell, followed by 15 mg/kg every 3-5 days during the long-dwell (the second dose should be time-based on a blood level obtained 2-4 days after the initial dose, see section 4.4).
Slovenian: Intermitentna terapija: začetni odmerek je 30 mg/kg in ga dodamo v raztopino dializata za menjavo, ki mu sledijo odmerki po 15 mg/kg vsake 3-5 dni v raztopino dializata za menjavo, (drugi odmerek je treba časovno določiti glede na vrednosti, dobljene 2-4 dni po prvem odmerku, glejte poglavje 4.4).
English: Exfoliative dermatitis, Stevens-Johnson syndrome, Lyell's syndrome, Linear IgA bullous dermatosis
Slovenian: Zelo redki eksfoliativni dermatitis, Stevens Johnsonov sindrom, Lyellov sindrom, s protitelesi IgA induciran bulozni dermatitis
English: 4 to 6 weeks**
Slovenian: 4 do 6 tednov**
English: In non-inflamed meninges, vancomycin passes the blood-brain barrier only to a low extent.
Slovenian: Če možganska ovojnica ni vneta, vankomicin samo v majhni meri prehaja skozi krvno-možgansko pregrado.
English: Intravenous administration
Slovenian: Intravenska uporaba
English: Oral Administration Patients aged 12 years and older
Slovenian: Peroralna uporaba Bolniki, stari 12 let ali več
English: Bone and joint infections
Slovenian: Okužbe kosti in sklepov
English: Very rare
Slovenian: Redko vaskulitis
English: Development of Drug-Resistant Bacteria
Slovenian: Razvoj bakterij, odpornih na zdravilo
English: The recommended vancomycin dose is 10 mg/kg orally every 6 hours for 10 days.
Slovenian: Priporočeni odmerek vankomicina je 10 mg/kg telesne mase na vsakih 6 ur.
English: Therefore, the below mentioned adverse reactions and frequencies related to parenteral vancomycin administration are included.
Slovenian: Zato so spodaj navedeni neželeni učinki in njihova pogostnost pojavljanja pri parenteralni uporabi vankomicina.
English: The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections.
Slovenian: Prevalenca pridobljene odpornosti se lahko za izbrane vrste razlikuje geografsko in časovno.
English: The combination of vancomycin with a cephalosporin has a synergistic effect against some oxacillin-resistant Staphylococcus epidermidis strains, and the combination of vancomycin with rifampicin has a synergistic effect against Staphylococcus epidermidis and a partial synergistic effect against some Staphylococcus aureus strains.
Slovenian: Kombinacija vankomicina s cefalosporini ima sinergističen učinek proti nekaterim na oksacilin odpornih sevom Staphylococcus epidermidis, kombinacija vankomicina z rifampicinom pa ima sinergističen učinek na Staphylococcus epidermidis in delno sinergističen učinek pri nekaterih sevih Staphylococcus aureus.
English: Significantly increased doses may be required to achieve therapeutic serum concentrations in pregnant women (see Section 4.6).
Slovenian: Pri nosečnicah bo za doseganje terapevtske koncentracije v serumu morda treba precej povečati odmerek (glejte poglavje 4.6).
English: 4 to 6 weeks*
Slovenian: 4 do 6 tednov*
English: Model-based methods may be useful in the prediction of individual dose requirements to reach an adequate AUC.
Slovenian: Pri določevanju, kakšna velikost odmerka je pri posamezniku potrebna, da bi dosegli ustrezen AUC, lahko uporabimo metode na podlagi modeliranja.
English: Cross-resistance with other glycopeptide antibiotics, such as teicoplanin, does occur.
Slovenian: Včasih pride do navzkrižne odpornosti med drugimi glikopeptidnimi antibiotiki, kot je teikoplanin.
English: Administration site related reactions
Slovenian: Reakcije na mestu uporabe
English: Drug interactions with anaesthetic agents
Slovenian: Interakcije zdravila z anestetiki
English: Minimum inhibitory concentration breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) are as follows:
Slovenian: Mejne vrednosti, ki temeljijo na testih Evropskega odbora za preskušanje za protimikrobne občutljivosti (EUCAST):
English: Lower maintenance doses may be required due to the age-related reduction in renal function.
Slovenian: Pri starejših bolnikih bo morda treba zmanjšati odmerke zdravila zaradi zmanjšanega delovanja ledvic.
English: The most common adverse reactions are phlebitis, pseudo-allergic reactions and flushing of the upper body (“red-neck syndrome”) in connection with too rapid intravenous infusion of vancomycin.
Slovenian: Najpogostejši neželeni učinki so flebitis, psevdoalergijske reakcije, pordelost zgornjega dela telesa (»sindrom rdečega moža«) pri prehitrem intravenskem infundiranju vankomicina.
English: Vancomycin should be used with care in patients with renal insufficiency, including anuria, as the possibility of developing toxic effects is much higher in the presence of prolonged high blood concentrations.
Slovenian: Pri bolnikih z ledvično insufienco, vključno z anurijo, je treba vankomicin uporabljati previdno, sa je verjetnost za razvoj toksičnih učinkov ob dolgotrajno visokih koncentracijah veliko večja.
English: In obese patients, the initial dose should be individually adapted according to total body weight as in non-obese patients.
Slovenian: Pri bolnikih s prekomerno telesno maso je treba začetni odmerek prilagoditi posamezniku glede na skupno telesno maso, tako kot pri bolnikih z normalno telesno maso.
English: Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units.
Slovenian: Vankomicin je triciklični glikopeptidni antibiotik, ki zavira sintezo celične stene občutljivih bakterij, tako da se z veliko afiniteto veže na D-alanil-D-alaninski konec prekurzorskih enot celične stene.
English: The frequency of therapeutic drug monitoring (TDM) needs to be individualized based on the clinical situation and response to treatment, ranging from daily sampling that may be required in some hemodynamically unstable patients to at least once weekly in stable patients showing a treatment response.
Slovenian: Pri nekaterih hemodinamično nestabilnih bolnikih je lahko potrebno vsakodnevno vzorčenje, pri hemodinamično stabilnih bolnikih, ki se odzivajo na zdravljenje, pa lahko zadošča preverjanje vsaj enkrat na teden.
English: What Vancomycin is and what it is used for
Slovenian: Kaj je zdravilo [Ime zdravila] in za kaj ga uporabljamo
English: Vancomycin should be used with caution in patients with allergic reactions to teicoplanin, since cross hypersensitivity, including fatal anaphylactic shock, may occur.
Slovenian: Pri bolnikih z alergijskimi reakcijami na teikoplanin moramo biti previdni pri uporabi vankomicina, saj lahko pride do navzkrižne preobčutljivosti, tudi do usodnega anafilaktičnega šoka.
English: Ototoxicity has primarily been reported in patients given high doses, or in those on concomitant treatment with other ototoxic medicinal product like aminoglycoside, or in those who had a preexisting reduction in kidney function or hearing.
Slovenian: O ototoksičnosti poročajo predvsem pri bolnikih, ki so dobili velike odmerke, ali pri tistih, ki so jih hkrati zdravil z drugimi ototoksičnimi zdravili, kot je aminoglikozid, ali pri tistih, ki so pred zdravljenem imeli težave z zmanjšanim delovanjem ledvic ali s sluhom.
English: Pseudomembranous enterocolitis
Slovenian: Psevdomembranski enterokolitis
English: Vancomycin is used in adults and adolescents from 12 years of age for the treatment of infections of the mucosa of the small and the large intestines with damage to the mucosae (pseudomembranous colitis), caused by the Clostridium difficile bacterium.
Slovenian: Vankomicin uporabljamo pri odraslih in mladostnikih, starejših od 12 let, za zdravljenje okužb sluznice tankega in debelega črevesa s poškodbami sluznice (psevdomembranski kolitis), ki so posledice bakterije Clostridium difficile.
English: Continuous infusion: loading dose of 1000 mg/L per litter of dialysate followed by 25 mg/L (after 3-6 h of loading dose) in all exchanges.
Slovenian: Kontinuirana infuzija: začetni odmerek je 1000 mg/l na liter dializata, ki mu sledi 25 mg/l (3-6 ur po začetnem odmerku) v vseh menjavah.
English: NAME OF THE MEDICINAL PRODUCT [For all vancomycin 125 mg capsule] <{(Invented) vancomycin 125mg capsule}> [For all vancomycin 250 mg capsule] <{(Invented) vancomycin 250mg capsule}>
Slovenian: IME ZDRAVILA [Za vse kapsule vankomicina 125 mg] <{(Izmišljeno ime) 125 mg kapsule}> [Za vse kapsule vankomicina 250 mg] <{(Izmišljeno ime) 250 mg kapsule}>
English: The absorption of vancomycin from the gastrointestinal tract is negligible.
Slovenian: Absorpcija vankomicina iz prebavnega sistema je zanemarljiva.
English: During or shortly after rapid infusion anaphylactic/anaphylactoid reactions including wheezing may occur.
Slovenian: Med ali kmalu po hitri infuziji lahko pride do anafilaktičnih ali anafilaktoidnih reakcij, tudi do piskajočega dihanja.
English: During anaesthesia, doses must be well diluted and administered slowly with close cardiac monitoring.
Slovenian: Med anestezijo mora biti odmerek močno razredčen in treba ga je dovajati počasi.
English: In case of severe persistent diarrhoea the possibility of pseudomembranous enterocolitis that might be life-threatening has to be taken into account (see section 4.8).
Slovenian: V primeru dolgotrajne hude driske lahko pride do smrtno nevarnega psevdomembranskega enterokolitisa (glejte poglavje 4.8).
English: When using for the treatment of infections related to peritoneal dialysis, your doctor will decide exactly how much vancomycin you need.
Slovenian: Pri zdravljenju okužb, povezanih s peritonealno dializo, vam bo zdravnik predpisal primeren odmerek vankomicina.
English: Depending on the clinical situation, consideration could be given to withhold the next dose while awaiting the results of vancomycin levels.
Slovenian: Od kliničnega stanja je odvisno, ali se bomo odločili počakati z naslednjim odmerkom, dokler ne izvemo vrednosti za vankomicin v serumu.
English: In neonates, after intravenous administration, vancomycin volume of distribution varies between 0.38 and 0.97 L/kg, similar to adult values, while clearance varies between 0.63 and 1.4 ml/kg/min.
Slovenian: Pri novorojenčkih, po intravenski uporabi, se volumen porazdelitve giblje med 0,38 in 0,97 l/kg, kar so podobne vrednosti kot pri odraslih.
English: Stopping the infusion usually results in a prompt cessation of these reactions.
Slovenian: Te reakcije običajno takoj izginejo, če ustavite injiciranje.
English: Vancomycin pharmacokinetics is not altered in patients with hepatic impairment.
Slovenian: Farmokinetika vankomicina pri bolnikih z okvaro jeter ni spremenjena.
English: [For parenteral formulations authorised for intraperitoneal use:] - In patients receiving peritoneal dialysis, vancomycin is used in adults and children for the treatment of infections related to peritoneal dialysis.
Slovenian: [Za parenteralna zdravila, odobrena za intraperitonealno uporabo:] - Pri bolnikih, odraslih in otrocih, ki prejemajo peritonealno dializo, zdravimo okužbe, povezane s peritonealno dializo.
English: Synergism
Slovenian: Sinergizem
English: This may be associated with a high fever and joint pains - Cardiac arrest - Inflammation of the bowel which causes abdominal pain and diarrhea, which may contain blood Not known (frequency cannot be estimated from the available data): - Being sick (throwing up), diarrhoea - Confusion, drowsiness, lack of energy, swelling, fluid retention, decreased urine - Rash with swelling or pain behind the ears, in the neck, groin, under the chin and armpits (swollen lymph nodes), abnormal blood and liver function tests - Rash with blisters and fever.
Slovenian: To lahko spremljajo visoka vročina in bolečine v sklepih - srčni zastoj - vnetje črevesja z bolečinami v trebuhu in drisko, v blatu se lahko pojavi kri Neznana pogostnost (pogostnosti iz razpoložljivih podatkov ni mogoče ugotoviti): - bruhanje, driska - zbeganost, dremavost, pomanjkanje energije, zatekanje, zastajanje tekočine, manj pogosto uriniranje - izpuščaj z oteklino ali bolečino za uhlji, v vratu, dimljah, pod brado in pazduhami (otečene bezgavke), nenormalni izvidi krvi in delovanja jeter - izpuščaj z mehurji in vročina
English: - Necrotizing
Slovenian: -nekrotizirajoče
English: Cardiac disorders Very rare
Slovenian: Srčne bolezni: Zelo redko srčni zastoj
English: 15 mg/kg
Slovenian: 15 mg/kg na 24 ur
English: Pregnancy
Slovenian: Nosečnice
English: Adults and adolescents (from 12 years and older) The dosage will be calculated according to your body weight.
Slovenian: Uporaba pri odraslih in otrocih, starejših od 12 let Odmerek bodo izračunali glede na vašo telesno maso.
English: Drug fever, shivering, Pain and muscle spasm of the chest and back muscles
Slovenian: Redki z zdravilom povzročena vročina, drgetanje, bolečina in krči v mišicah prsi in hrbta
English: Preterm and term newborn infants (from 0 to 27 days) The dosage will be calculated according to post-menstrual age (time elapsed between the first day of the last menstrual period and birth (gestational age) plus the time elapsed after birth (post-natal age).
Slovenian: Odmerek bo izračunan glede na postmenstrualno starost (čas od prvega dne zadnje menstruacije do rojstva (gestacijska starost) plus čas po rojstvu (postnatalna starost)).
English: Vancomycin powder is made into a <solution for infusion> <or> <oral solution>.
Slovenian: Vankomicin je prašek, iz katerega pripravimo <raztopino za infundiranje><ali><peroralno raztopino.>
English: Vancomycin capsules are indicated in patients 12 years and older for the treatment of Clostridium difficile infection (CDI) (see sections 4.2, 4.4 and 5.1).
Slovenian: Vankomicin v obliki kapsul je primeren za zdravljene bolnikov, starejših od 12 let, pri okužbah z bakterijo Clostridium difficile (CDI, Clostridium difficile infection) (glejte poglavja 4.2, 4.4 in 5.1).
English: Oral Use Only
Slovenian: Samo za peroralno uporabo
English: One possible way of dosing vancomycin in neonates is illustrated in the following table: (see section 4.4)
Slovenian: Primer odmerjanja vankomicina pri novorojenčkih je prikazan v spodnji preglednici: (glejte poglavje
English: When vancomycin is administered parenterally, the most common adverse reactions are phlebitis, pseudo-allergic reactions and flushing of the upper body (“red-neck syndrome”) in connection with too rapid intravenous infusion of vancomycin.
Slovenian: Pri parenteralni uporabi vankomicina so najbolj pogosti neželeni učinki flebitis, psevdoalergijske reakcije in pordelost zgornjega dela telesa (»sindrom rdečega vratu«) pri prehitrem intravenskem infundiranju vankomicina.
English: Vancomycin should not be administered intramuscularly due to the risk of necrosis at the site of administration.
Slovenian: Vankomicina ne smemo vnesti intramuskularno, saj lahko pride do nekroze na mestu vnosa.
English: 2 - Strictly follow the prescription.
Slovenian: 1 - atibiotike uporabljajte le, če vam jih predpiše zdravnik 2 - natančno upoštevajte recept
English: No dose adjustment is needed in patients with hepatic insufficiency.
Slovenian: Pri bolnikih z okvarjenim delovanjem jeter prilagoditev odmerkov ni potrebna.
English: Concomitant administration of vancomycin and anaesthetic agents has been associated with erythema and histamine-like flushing in children.
Slovenian: Hkratna uporaba vankomicina in anestetikov pri otrocih lahko povzroči eritem in odzive, podobne histaminskemu.
English: - Being sick (throwing up), diarrhoea - Confusion, drowsiness, lack of energy, swelling, fluid retention, decreased urine - Rash with swelling or pain behind the ears, in the neck, groin, under the chin and armpits (swollen lymph nodes), abnormal blood and liver function tests - Rash with blisters and fever.
Slovenian: - zbeganost, dremavost, pomanjkanje energije, zatekanje, zastajanje tekočine, manj pogosto uriniranje - izpuščaj z oteklino ali bolečino za uhlji, v vratu, dimljah, pod brado in pazduhami (otečene bezgavke), nenormalni izvidi krvi in delovanja jeter - izpuščaj z mehurji in vročina
English: In patients on intermittent haemodialysis, vancomycin levels should be usually obtained before the start of the haemodialysis session.
Slovenian: Pri bolnikih na intermitentni hemodializi je treba raven vankomicina preveriti pred začetkom naslednje hemodialize.
English: Hypersensitivity to the active substance or to any of the excipients (see section 4.4).
Slovenian: 4.3 Kontraindikacije Preobčutljivost za vankomicin ali katero koli pomožno snov (glejte poglavje 4.4).
English: However, if you have an inflammatory disorder of the digestive tract, especially if you also have a kidney disorder, similar side effects as those that occur when vancomycin is given by infusion may appear.
Slovenian: Če pa imate vnetno bolezen prebavil, še posebej če imate hkrati tudi motnje v delovanju ledvic, lahko pride do podobnih neželenih učinkov kot pri vankomicinu, ki ga dobite v obliki infuzije.
English: Vancomycin is administered intravenously for the treatment of systemic infections.
Slovenian: Za zdravljenje sistemskih okužb vankomicin uporabimo intravensko.
English: Serial monitoring of renal function should be performed when treating patients with underlying renal dysfunction or patients receiving concomitant therapy with an aminoglycoside or other nephrotoxic drugs.
Slovenian: Treba je redno preverjati delovanje ledvic pri bolnikih z okvarjenim delovanjem ledvic in pri bolnikih, ki imajo hkrati terapijo z aminoglikozidom ali drugimi nefrotoksičnimi zdravili.
English: Renal function must be taken into consideration for subsequent doses and interval of administration.
Slovenian: Pri nadaljnjih odmerkih in določanju intervalov med odmerki je treba upoštevati ledvično funkcijo.
English: Vancomycin should be used with particular care in premature neonates and young infants, because of their renal immaturity and the possible increase in the serum concentration of vancomycin.
Slovenian: Vankomicin je treba uporabljati še posebej previdno pri nedonošenčkih in dojenčkih, saj še nimajo povsem razvitih ledvic in obstaja verjetnost za zvišanje ravni vankomicina v serumu.
English: [For parenteral formulations authorised for intraperitoneal use:] Intraperitoneal administration
Slovenian: [Za parenteralna zdravila, odobrena za intraperitonealno uporabo:] Intraperitonealna uporaba
English: No blood concentrations were detected and urinary recovery did not exceed
Slovenian: V krvi niso našli sledi zdravila, v urinu pa delež učinkovine ni presegel 0,76%.
English: [For parenteral formulations authorised for oral use:] The absorption of vancomycin from the gastrointestinal tract is negligible.
Slovenian: [Za parenteralna zdravila, odobrena za peroralno uporabo:] Prevzem vankomicina iz prebavnega sistema v telo je zanemarljiv.
English: Oral vancomycin use increases the chance of vancomycin-resistant Enterococci populations in the gastrointestinal tract.
Slovenian: Pri peroralni uporabi vankomicina se poveča tveganje za namnožitev na vankomicin odpornoh populacij enterokokov v prebavnem sistemu.
English: Vancomycin is active against gram-positive bacteria, such as staphylococci, streptococci, enterococci, pneumococci, and clostridia.
Slovenian: Vankomicin je učinkovit proti po Gramu pozitivnih bakterijam, kot so stafilokoki, streptokoki, enterokoki, pnevmokoki in klostridij.
English: Peritoneal dialysis-associated peritonitis
Slovenian: Peritonitis zaradi peritonealne dialize
English: After oral administration, monitoring vancomycin serum concentrations in patients with inflammatory intestinal disorders should be performed (see section 4.4).
Slovenian: Pri peroralni uporabi vankomicina je pri bolnikih z vnetnimi črevesnimi boleznimi treba nadzirati koncentracijo vankomicina v serumu (glejte poglavje 4.4).
English: Each vial contains 1000 mg contains vancomycin hydrochloride equivalent to 1,000,000 IU vancomycin.
Slovenian: Ena viala vsebuje vankomicinijev klorid v količini, ki ustreza 1000 mg (1 000 000 i.e.) vankomicina.
English: In some countries, increasing cases of resistance are observed particularly in enterococci; multi-resistant strains of Enterococcus faecium are especially alarming.
Slovenian: Še posebej je zaskrbljujpče pojavljanje multiodpornih sevov bakterije Enterococcus faecium.
English: Vancomycin is indicated in all age groups for the treatment of Clostridium difficile infection (CDI) (see sections 4.2, 4.4 and 5.1).
Slovenian: Vankomicin uporabljamo za vse starostne skupine za zdravljenje okužb z bakterijo Clostridium difficile (glejte poglavja 4.2, 4.4 in 5.1).
English: Vancomycin diffuses readily across the placenta and is distributed into cord blood.
Slovenian: Vankomicin skozi placento prehaja v popkovnično kri.
English: Each vial contains 500 mg vancomycin hydrochloride equivalent to 500,000 IU vancomycin.
Slovenian: Ena viala vsebuje vankomicinijev klorid v količini, ki ustreza 500 mg (500 000 i.e.) vankomicina.
English: [For all vancomycin 125 mg capsule] <{(Invented) vancomycin 125mg capsule}>
Slovenian: [Za vse kapsule vankomicina 125 mg] <{(Ime zdravila) 125 mg kapsule}>
English: Anti-diarrhoeic medicinal products must not be given.
Slovenian: Bolniku ne smemo dati zdravil proti driski.
English: In patients with impaired renal function the terminal elimination half- life of vancomycin is prolonged and the total body clearance is reduced.
Slovenian: Pri bolnikih z ledvično okvaro je razpolovni čas izločanja podaljšan in skupni očistek manjši.
English: Continuous vancomycin infusion may be considered, e.g., in patients with unstable vancomycin clearance.
Slovenian: V nekaterih primerih, npr. pri bolnikih z nestabilnim očistkom vankomicina, lahko razmislimo o kontinuirani infuziji.
English: This may lead to vancomycin accumulation in patients with co-existing renal impairment.
Slovenian: To lahko pri bolnikih, ki imajo hkrati ledvično okvaro, privede do kopičenja vankomicina.