FrancophonIA/ELRC3.0 huggingface dataset:
English: It is not known whether darunavir, cobicistat, or tenofovir alafenamide are excreted in human milk.
Danish: Det er ukendt, om darunavir, cobicistat eller tenofoviralafenamid udskilles i human mælk.
English: Patients co-infected with HIV and HBV who discontinue Symtuza should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment.
Danish: Symtuza, skal monitoreres tæt både med klinisk og laboratoriemæssig opfølgning i mindst flere måneder efter afbrydelsen af behandlingen.
English: The effect of severe hepatic impairment (Child-Pugh Class C) on the pharmacokinetics of cobicistat has not been studied.
Danish: Effekten af svært nedsat leverfunktion (Child-Pugh klasse C) på cobicistats farmakokinetik er ikke blevet undersøgt.
English: The pharmacokinetics of Symtuza have not been investigated in paediatric patients.
Danish: Symtuzas farmakokinetik er ikke blevet undersøgt hos pædiatriske patienter.
English: Via C. Janssen, Borgo San Michele
Danish: Janssen-Cilag SpA Via C. Janssen, Borgo San Michele
English: HIV-1 RNA ≥ 50 copies/mL Virologic Failure Leading to Discontinuation Discontinued study drug due to other reasons and last available HIV-1 RNA ≥ 50 copies/mL
Danish: Hiv-1 RNA ≥50 kopier/ml Virologisk svigt, der medførte afbrydelse Forsøgsmedicin seponeret af andre årsager og seneste tilgængelige hiv-1 RNA ≥50 kopier/ml
English: In vivo, tenofovir alafenamide is hydrolysed within cells to form tenofovir (major metabolite), which is phosphorylated to the active metabolite tenofovir diphosphate.
Danish: In vivo hydrolyseres tenofoviralafenamid i cellerne, hvorved der dannes tenofovir (primær metabolit), som fosforyleres til den aktive metabolit tenofovirdiphosphat.
English: Based on theoretical considerations DRV/COBI is expected to increase the plasma concentrations of fluvastatin, pitavastatin, pravastatin, lovastatin and simvastatin.
Danish: Baseret på teoretiske overvejelser forventes DRV/COBI at øge plasmakoncentrationen af fluvastatin, pitavastatin, pravastatin, lovastatin og simvastatin.
English: Co-administration of Symtuza with oxcarbazepine is not recommended.
Danish: Co-administration af Symtuza med oxcarbazepin frarådes.
English: No human data on the effect of darunavir, cobicistat, emtricitabine, or tenofovir alafenamide on fertility are available.
Danish: Der foreligger ingen data om virkningen af darunavir, cobicistat, emtricitabin eller tenofoviralafenamid på fertiliteten hos mennesker.
English: • allergic reactions such as nettle rash (urticaria), itching, decreased appetite (anorexia)
Danish: • allergiske reaktioner såsom nældefeber (urticaria), kløe
English: Do not use this medicine after 6 weeks of first opening the bottle.
Danish: Anvendes inden 6 uger efter første åbning af beholderen.
English: The effect of severe hepatic impairment (Child-Pugh Class C) on the pharmacokinetics of tenofovir alafenamide has not been studied.
Danish: Effekten af svært nedsat leverfunktion (Child-Pugh klasse C) på tenofoviralafenamids farmakokinetik er ikke blevet undersøgt.
English: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection (unusual infections due to a weakened immune system), signs and symptoms of inflammation from previous infections may occur soon after HIV treatment is started, including Symtuza.
Danish: Hos nogle patienter med fremskreden hiv-infektion (aids), som tidligere har haft opportunistiske infektioner (usædvanlige infektioner på grund af et svækket immunforsvar), kan tegn og symptomer på betændelse fra tidligere infektioner vise sig kort efter påbegyndelse af hiv-behandling, også med Symtuza.
English: • enlargement of breasts
Danish: • forstørrelse af bryster
English: Discontinued study drug due to other reasons and last available HIV-1 RNA < 50 copies/mL Missing data during window but on trial Virologic response (HIV-1-RNA < 50 copies/mL; Snapshot Analysis) by subgroup, n/N (%)
Danish: Forsøgsmedicin seponeret af andre årsager og seneste tilgængelige hiv-1 RNA < 50 kopier/ml Manglende data i vinduet men med i studiet Virologisk respons (hiv-1-RNA <50 kopier/ml; snapshot-analyse) efter undergruppe, n/N (%) Alder <50 år ≥50 år
English: Gastrointestinal disorders very common diarrhoea common vomiting, nausea, abdominal pain, abdominal distension, dyspepsia, flatulence uncommon pancreatitis acute, pancreatic enzymes increased
Danish: Mave-tarm-kanalen meget almindelig diarré almindelig opkastning, kvalme, abdominalsmerter, abdominal distention, dyspepsi, flatulens ikke almindelig akut pankreatitis, forhøjede pankreasenzymer
English: Cobicistat is a mechanism based inhibitor of CYP3A, and a weak CYP2D6 inhibitor.
Danish: Cobicistat er en mekanismebaseret CYP3A-hæmmer og en svag CYP2D6-hæmmer.
English: At least 3 oxidative metabolites of darunavir have been identified in humans; all showed activity that was at least 10-fold less than the activity of darunavir against wild type HIV.
Danish: Alle viste en aktivitet over for vildtype hiv, der var mindst 10 gange mindre end darunavirs aktivitet.
English: CORTICOSTEROIDS Budesonide
Danish: KORTIKOSTEROIDER Budesonid
English: Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and cobicistat, resulting in lowered plasma concentrations of darunavir and cobicistat (e.g. efavirenz, carbamazepine, phenytoin, phenobarbital, rifampicin, rifapentine, rifabutin, St. John's wort) (see section 4.3 and interaction table below).
Danish: Lægemidler, der inducerer CYP3A-aktivitet, må forventes at øge clearance af darunavir og cobicistat, hvilket kan medføre en lavere plasmakoncentration af darunavir og cobicistat (f.eks. efavirenz, carbamazepin, phenytoin, phenobarbital, rifampicin, rifapentin, rifabutin, perikon) (se pkt.
English: Co-administration of oral midazolam or triazolam and Symtuza is contraindicated (see section 4.3).
Danish: Co-administration af oral midazolam eller triazolam og Symtuza er kontraindiceret (se pkt.
English: Symtuza should be discontinued in patients with eGFRCG that declines below 30 mL/min during treatment (see sections 5.1 and 5.2).
Danish: Symtuza skal seponeres hos patienter med eGFRCG, der falder til under 30 ml/min under behandling (se pkt.
English: Using Cyst C as filtration marker, the median changes in estimated glomerular filtration rate calculated using the CKD-EPI (eGFRCKD-EPI CystC) formula were respectively 4.0 mL/min/1.73 m² and 1.6 mL/min/1.73 m² (p<0.001).
Danish: Med Cyst C som filtrationsmarkør blev middelændringen i estimeret glomerulær filtrationshastighed beregnet ved hjælp af formlen CKD-EPI (eGFRCKD-EPI CystC) til henholdsvis 4,0 ml/min/1,73 m² og 1,6 ml/min/1,73 m² (p<0,001).
English: Included subjects who had ≥ 50 copies/mL in the Week 48/96 window; subjects who discontinued early due to lack or loss of efficacy per investigator's assessment; subjects who discontinued for reasons other than an adverse event (AE), death or lack or loss of efficacy and at the time of discontinuation had a viral value ≥ 50 copies/mL.
Danish: Inkluderede forsøgspersoner, som havde ≥50 kopier/ml i uge 48/96-vinduet; forsøgspersoner, som afbrød behandlingen før tid på grund af manglende virkning eller tab af virkning i henhold til investigators vurdering; forsøgspersoner, som afbrød behandlingen af andre årsager end bivirkning (AE), død eller manglende virkning eller tab af virkning, og som på tidspunktet for afbrydelsen havde en viral værdi ≥ 50 kopier/ml.
English: Based on theoretical considerations co-administration of DRV/COBI with dabigatran or ticagrelor may increase concentrations of the anticoagulant.
Danish: Baseret på teoretiske overvejelser kan co-administration af DRV/COBI med dabigatran eller ticagrelor øge koncentrationen af antikoagulansen.
English: The median terminal plasma half-life of darunavir following administration of Symtuza is 5.5 hours.
Danish: Darunavirs mediane terminale plasmahalveringstid efter administration af Symtuza er 5,5 timer.
English: The combination of colchicine and Symtuza is contraindicated in patients with renal or hepatic impairment (see section 4.3).
Danish: Kombination af colchicin og Symtuza er kontraindiceret hos patienter med nedsat nyre- eller leverfunktion (se pkt.
English: For these neuroleptics, consider reducing the dose of the neuroleptic upon co-administration with Symtuza.
Danish: Dosisreduktion af disse neuroleptika bør overvejes ved co-administration med Symtuza.
English: Removing the child resistant cap
Danish: Fjernelse af det børnesikrede låg
English: Co-administration of amiodarone, dronedarone, ivabradine, quinidine, or ranolazine and Symtuza is contraindicated (see section 4.3).
Danish: Co-administration af amiodaron, dronedaron, ivabradin, kinin eller ranolazin og Symtuza er kontraindiceret (se pkt.
English: (P-glycoprotein inhibition)
Danish: (Hæmning af P-glykoprotein)
English: The combination of lurasidone, pimozide, quetiapine or sertindole and Symtuza is contraindicated (see section 4.3).
Danish: Kombinationen af lurasidon, pimozid, quetiapin eller sertindol og Symtuza er kontraindiceret (se pkt.
English: Treatment with darunavir/cobicistat (two of the components of Symtuza) during pregnancy results in low darunavir exposure (see sections 4.4 and 5.2).
Danish: Behandling med darunavir/cobicistat (to af indholdsstofferne i Symtuza) under graviditet fører til lav eksponering for darunavir (se pkt.
English: Symtuza has not been studied in patients with severe hepatic impairment (Child-Pugh Class C), therefore, Symtuza must not be used in patients with severe hepatic impairment (see sections 4.3, 4.4 and 5.2).
Danish: Symtuza er ikke blevet undersøgt hos patienter med svært nedsat leverfunktion (Child-Pugh klasse C), og Symtuza må derfor ikke anvendes til patienter med svært nedsat leverfunktion (se pkt.
English: Clinical monitoring is recommended when co-administering Symtuza with beta-blockers and a lower dose of the beta-blocker should be considered.
Danish: Klinisk monitorering anbefales ved co-administration af Symtuza med betablokkere, og en lavere dosis af betablokkeren bør overvejes.
English: Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) and nucleoside analogue of 2'-deoxycytidine.
Danish: Emtricitabin er en nukleosid revers-transkriptasehæmmer (NRTI) og en nukleosidanalog af 2'-deoxycytidin.
English: Patients co-infected with HIV and hepatitis B or C virus
Danish: Patienter med samtidig hiv- og hepatitis B- eller C-virusinfektion
English: No clinically relevant pharmacokinetic differences due to age have been identified for cobicistat, emtricitabine or tenofovir alafenamide in the age range ≤ 65 years.
Danish: Der er ikke blevet identificeret klinisk relevante farmakokinetiske forskelle for cobicistat, emtricitabin eller tenofoviralafenamid på grund af alder i aldersgruppen ≤ 65 år.
English: Croscarmellose sodium Magnesium stearate Cellulose, microcrystalline Silica, colloidal anhydrouse
Danish: Croscarmellosenatrium Magnesiumstearat Cellulose, mikrokrystallinsk Silica, kolloid, vandfri
English: • If you notice within 12 hours of the time you usually take Symtuza, you must take the tablet immediately, with food.
Danish: • Hvis du kommer i tanke om den glemte dosis inden for 12 timer efter det tidspunkt, hvor du normalt tager Symtuza, skal du straks tage en tablet sammen med mad.
English: Using Cyst C as filtration marker, the median change in estimated glomerular filtration rate calculated using the CKD-EPI (eGFRCKD-EPI Cyst C) formula (N=22) was +4.4 mL/min/1.73 m² with D/C/F/TAF.
Danish: Med Cyst C som filtrationsmarkør blev middelændringen i estimeret glomerulær filtrationshastighed beregnet ved hjælp af formlen CKD-EPI (eGFRCKD-EPI CystC) (N=22) til +4,4 ml/min/1,73 m2 med D/C/F/TAF.
English: The antiviral activity of tenofovir alafenamide against laboratory and clinical isolates of HIV-1 subtype B was assessed in lymphoblastoid cell lines, PBMCs, primary monocyte/macrophage cells and CD4+-T lymphocytes.
Danish: Tenofoviralafenamids antivirale aktivitet mod laboratorie- og kliniske isolater af hiv-1 undertype B blev vurderet i lymfoblastoide cellelinjer, PBMC'er, primære monocyt-/makrofag-celler og CD4+-T-lymfocytter.
English: It is not recommended to co-administer Symtuza with glecaprevir/pibrentasvir.
Danish: Det frarådes at co-administrere boostet Symtuza og glecaprevir/pibrentasvir.
English: CD4+ cell count mean change from baseline
Danish: CD4+-celletal, gennemsnitlig ændring fra baseline
English: Human experience of acute overdose with Symtuza is limited.
Danish: Der er kun begrænset erfaring med akut overdosering af Symtuza hos mennesker.
English: Clinical monitoring is recommended when co-administering Symtuza with corticosteroids.
Danish: Klinisk monitorering anbefales ved co-administration af Symtuza med kortikosteroider.
English: Hepatobiliary disorders common hepatic enzyme increased uncommon acute hepatitis a, cytolytic hepatitis
Danish: Lever og galdeveje almindelig forhøjede leverenzymer ikke almindelig akut hepatitis a, cytolytisk hepatitis
English: No clinically relevant differences in cobicistat pharmacokinetics were observed between subjects with moderate impairment and healthy subjects.
Danish: Der blev ikke observeret klinisk relevante forskelle i cobicistats farmakokinetik mellem personer med moderat nedsat funktion og raske personer.
English: No special hazard for humans was revealed in conventional studies of carcinogenic potential and toxicity to reproduction and development.
Danish: Der udvistes ingen speciel risiko for mennesker i konventionelle studier af karcinogent potentiale og reproduktions- og udviklingstoksicitet.
English: No meaningful differences in cobicistat pharmacokinetics were observed between subjects with severe renal impairment and healthy subjects, consistent with low renal clearance of cobicistat.
Danish: Der blev ikke observeret nogen klinisk relevante forskelle i cobicistats farmakokinetik hos personer med svært nedsat nyrefunktion sammenlignet med raske personer, hvilket er i overensstemmelse med cobicistats lave renale clearance.
English: What Symtuza contains
Danish: Symtuza indeholder:
English: ANTACIDS Aluminium/magnesium hydroxide
Danish: Aluminium/magnesiumhydroxid Calciumcarbonat
English: If you take more Symtuza than you should
Danish: Hvis du har taget for mange Symtuza
English: Included subjects who had HIV-1 RNA ≥ 50 copies/mL in the Week 48/96 window; subjects who discontinued early due to lack or loss of efficacy per investigator's assessment; subjects who discontinued for reasons other than an adverse event (AE), death or lack or loss of efficacy and at the time of discontinuation had a HIV-1 RNA ≥ 50 copies/mL.
Danish: Inkluderede forsøgspersoner, som havde hiv-1 RNA ≥50 kopier/ml i uge 48/96-vinduet; forsøgspersoner, som afbrød behandlingen før tid på grund af manglende virkning eller tab af virkning i henhold til investigators vurdering; forsøgspersoner, som afbrød behandlingen af andre årsager end bivirkning (AE), død eller manglende virkning eller tab af virkning, og som på tidspunktet for afbrydelsen havde et hiv-1 RNA ≥ 50 kopier/ml.
English: In studies in treatment-naïve patients, Symtuza was associated with a lower impact on the estimated glomerular filtration rate by Cockcroft-Gault method compared to control group (DRV/COBI+F/TDF).
Danish: I studier med behandlingsnaive patienter var Symtuza, i forhold til kontrolgruppen (DRV/COBI+F/TDF), associeret med en mindre påvirkning af den estimerede glomerulære filtrationsrate bestemt ved til Cockcroft-Gault-metoden.
English: If you vomit more than 1 hour after taking the medicine, then you do not need to take another dose of Symtuza until the next regularly scheduled time.
Danish: Hvis du kaster op mere end 1 time efter, du har taget lægemidlet, behøver du ikke at tage en ny dosis Symtuza før det næste planlagte tidspunkt.
English: Symtuza should be used with caution in patients with a known sulphonamide allergy.
Danish: Darunavir indeholder en sulfonamid-del. Symtuza skal anvendes med forsigtighed hos patienter med kendt sulfonamidallergi.
English: Clinical monitoring is recommended when co-administering Symtuza with these analgesics.
Danish: Klinisk monitorering anbefales ved co-administration af Symtuza med disse analgetika.
English: Based on theoretical considerations boceprevir may decrease darunavir and/or cobicistat plasma concentrations and adversely affect the intracellular activation and clinical antiviral efficacy of tenofovir alafenamide.
Danish: Baseret på teoretiske overvejelser kan boceprevir nedsætte plasmakoncentrationen af darunavir og/eller cobicistat og have en negativ indflydelse på den intracellulære aktivering og kliniske antivirale virkning af tenofoviralafenamid.
English: Subjects with ≥1 emergent RAM, n (%) Protease
Danish: Forsøgsdeltagere med ≥1 ny RAM, n
English: PROTON PUMP INHIBITORS Dexlansoprazole
Danish: PROTONPUMPEHÆMMERE Dexlansoprazol
English: You should also not take Symtuza with medicines that contain tenofovir disoproxil (e.g. as fumarate, phosphate, or succinate), lamivudine or adefovir dipivoxil, or medicines that require boosting with ritonavir or cobicistat.
Danish: Du må heller ikke tage Symtuza sammen med lægemidler, der indeholder tenofovirdisoproxil (f.eks. som fumarat, fosfat eller succinat), lamivudin eller adefovirdipivoxil, eller lægemidler, der kræver forstærkning med ritonavir eller cobicistat.
English: HIV-1 isolates with reduced susceptibility to tenofovir alafenamide express a K65R mutation in HIV-1 RT; in addition, a K70E mutation in HIV-1 RT has been transiently observed.
Danish: Hiv-1-isolater med nedsat følsomhed over for tenofoviralafenamid udtrykker en K65R-mutation i hiv-1 RT.
English: • If you notice 12 hours or more after the time you usually take Symtuza, then do not take the missed dose and take the next doses with food at your usual time.
Danish: • Hvis du kommer i tanke om den glemte dosis senere end 12 timer efter det tidspunkt, hvor du normalt tager Symtuza, må du ikke tage den glemte dosis, men skal blot tage den næste dosis på det sædvanlige tidspunkt.
English: BOTTLE LABEL
Danish: BEHOLDERETIKET
English: Darunavir is primarily metabolised and eliminated by the liver.
Danish: Darunavir metaboliseres og elimineres primært i leveren.
English: Some late-onset neurological disorders have been reported (hypertonia, convulsion, abnormal behaviour).
Danish: Der foreligger rapporter med senreaktioner i form af neurologiske forstyrrelser (hypertoni, kramper, usædvanlig opførsel).
English: Concomitant administration of Symtuza with dabigatran or ticagrelor is contraindicated (see section 4.3).
Danish: Samtidig administration af Symtuza og dabigatran eller ticagrelor er kontraindiceret (se pkt.
English: Simeprevir may increase darunavir and/or cobicistat plasma concentrations.
Danish: Simeprevir øger muligvis plasmakoncentrationen af darunavir og/eller cobicistat.
English: Emtricitabine displayed antiviral activity in cell culture against HIV-1 clades A, B, C, D, E, F, and G (EC50 values ranged from 0.007 to 0.075 μM) and showed strain specific activity against HIV-2 (EC50 values ranged from 0.007 to 1.5 μM).
Danish: Emtricitabin udviste antiviral aktivitet i cellekultur mod hiv-1kladerne A, B, C, D, E, F og G (EC50-værdierne var i intervallet fra 0,007 til 0,075 μM) og udviste stammespecifik aktivitet mod hiv-2 (EC50-værdierne var i intervallet fra 0,007 til 1,5 μM).
English: Skin and subcutaneous tissue disorders very common rash (including macular, maculopapular, papular, erythematous, pruritic rash, generalised rash, and allergic dermatitis)
Danish: Hud og subkutane væv meget almindelig udslæt (herunder makuløst, makulopapuløst, papuløst, erytematøst, kløende udslæt, generaliseret udslæt og allergisk dermatitis)
English: Co-administration of domperidone with Symtuza is contraindicated.
Danish: Co-administration af domperidon og Symtuza er kontraindiceret.
English: Co-administration of Symtuza and naloxegol is contraindicated.
Danish: Co-administration af Symtuza og naloxegol er kontraindiceret.
English: No emergent resistance to E/C/F/TAF (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) was detected through Week 48.
Danish: Indtil uge 48 blev der ikke detekteret nogen virologisk resistens over for E/C/F/TAF (elvitegravir/cobicistat/emtricitabin/tenofoviralafenamid).
English: Due to an increase in the unbound darunavir plasma concentrations, Symtuza should be used with caution in patients with mild or moderate hepatic impairment (see sections 4.2, 4.3 and 5.2).
Danish: På grund af en stigning i plasmakoncentrationen af ubundet darunavir skal Symtuza anvendes med forsigtighed hos patienter med let eller moderat nedsat leverfunktion (se pkt.
English: - Digoxin (to treat certain heart disorders) - Clarithromycin (antibiotic) - Clotrimazole, fluconazole, Isavuconazole, itraconazole, posaconazole, (for treating fungal infections).
Danish: - Clotrimazol, fluconazol, isavuconazol, itraconazol, posaconazol, (til behandling af svampeinfektioner).
English: Based on theoretical consideration, St. John's wort may substantially decrease DRV/COBI (CYP3A4 induction) and TAF exposures.
Danish: Baseret på teoretiske overvejelser kan perikon medføre en væsentligt reduceret eksponering for DRV/COBI (CYP3A4-induktion) og TAF.
English: Symtuza might increase the risk for elevated potassium levels by drospirenone.
Danish: Symtuza kan øge risikoen for, at drospirenon øger kaliumniveauet.
English: • emtricitabine, an anti-HIV medicine known as a nucleoside reverse transcriptase inhibitor
Danish: • emtricitabin, et hiv-lægemiddel, der kaldes en nukleosid revers-transkriptasehæmmer
English: The tablet core contains croscarmellose sodium, magnesium stearate, microcrystalline cellulose and colloidal silicon dioxide.
Danish: Tabletkernen indeholder croscarmellosenatrium, magnesiumstearat, mikrokrystallinsk cellulose og kolloid silica.
English: If a patient vomits more than 1 hour after taking the medicine, the patient does not need to take another dose of Symtuza until the next regularly scheduled time.
Danish: Hvis patienten kaster op mere end 1 time efter indtagelse af lægemidlet, er det ikke nødvendigt at tage en ny dosis Symtuza før det næste planlagte tidspunkt.
English: Co-administration of Symtuza with rifabutin and rifapentine is not recommended.
Danish: Co-administration af Symtuza og rifabutin og rifapentin frarådes.
English: a herbal product used for depression
Danish: et naturlægemiddel mod depression
English: Symtuza should not be used in paediatric patients below 3 years of age (see sections 4.2 and 5.3).
Danish: Symtuza bør ikke anvendes til pædiatriske patienter under 3 år (se pkt.
English: It is not recommended to co-administer Symtuza with simeprevir.
Danish: Det frarådes at co-administrere Symtuza med simeprevir.
English: No clinically relevant pharmacokinetic differences due to gender have been identified for cobicistat, emtricitabine or tenofovir alafenamide.
Danish: Der er ikke blevet identificeret klinisk relevante farmakokinetiske forskelle for cobicistat, emtricitabin eller tenofoviralafenamid på grund af køn.
English: The combination of rifampicin and Symtuza is contraindicated (see section 4.3).
Danish: Kombinationen af rifampicin og Symtuza er kontraindiceret (se pkt.
English: HIV-1 isolates with the K65R mutation have low-level reduced susceptibility to abacavir, emtricitabine, tenofovir, and lamivudine.
Danish: Hertil kommer, at der forbigående er observeret en K70E-mutation i hiv-1 RT. Hiv-1isolater med K65R-mutationen har en lav grad af nedsat følsomhed over for abacavir, emtricitabin, tenofovir og lamivudin.
English: Based on theoretical considerations DRV/COBI may increase the exposure to glecaprevir and pibrentasvir.
Danish: Baseret på teoretiske overvejelser kan DRV/COBI øge eksponeringen for glecaprevir og pibrentasvir.
English: The interaction profile of darunavir depends on whether ritonavir or cobicistat is used as a pharmacokinetic enhancer; therefore, there may be different recommendations for the use of darunavir with concomitant medicines.
Danish: Interaktionsprofilen for darunavir afhænger af, om ritonavir eller cobicistat benyttes som farmakokinetisk forstærker.