FrancophonIA/ELRC3.0 huggingface dataset:
English: The separation between the treatment arms was achieved by improvement in lung function in the pemetrexed /cisplatin arm and deterioration of lung function over time in the control arm.
Slovenian: Razlikovanje med vejama zdravljenja je bilo doseženo z izboljšanjem delovanja pljuč v veji zdravljenja s pemetreksed/cisplatinom in poslabšanjem pljučnega delovanja s časom v kontrolni veji preskušanja.
English: Hypernatraemia - increased sodium in blood Inflammation of the skin, mainly of the lower limb with swelling, pain and redness
Slovenian: Hipernatriemija - zvišana raven natrija v krvi Vnetje kože, večinoma spodnjih okončin, z otekanjem, bolečino in pordelostjo
English: If particulate matter is observed, do not administer.
Slovenian: Če opazite trdne delce, te viale ne uporabite.
English: In a study conducted in beagle dog by intravenous bolus injection for 9 months, testicular findings (degeneration/necrosis of the seminiferous epithelium) have been observed.
Slovenian: V 9-mesečni študiji, ki so jo izvedli na psih pasme beagle tako, da so jim dajali intravenske injekcije v bolusu, so opazovali spremembe na testisih (degeneracija/nekroza seminifernega epitelija).
English: Kidney: abnormal blood tests
Slovenian: Ledvice: nenormalne vrednosti krvnih testov
English: An insufficient number of patients have been studied with creatinine clearance of below 45 ml/min.
Slovenian: Zadostnega števila bolnikov z očistkom kreatinina pod 45 ml/min niso preučili.
English: If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive Pemetrexed Pfizer.
Slovenian: Če imate ali ste imeli težave z ledvicami, se pogovorite z zdravnikom ali bolnišničnim farmacevtom, ker morda ne boste mogli prejeti zdravila Pemetreksed Pfizer.
English: In vitro studies have shown that pemetrexed behaves as a multi-targeted antifolate by inhibiting thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotides.
Slovenian: Študije in vitro so pokazale, da se pemetreksed vede kot večtarčni antifolat z zaviranjem timidilatne sintaze (TS), dihidrofolatne reduktaze (DHFR) in glicinamidne ribonukleotidne formiltransferaze (GARFT), ki so ključni od folata odvisni encimi za de novo biosintezo timidinskih in purinskih nukleotidov.
English: 75% of previous dose (both pemetrexed and cisplatin)
Slovenian: 75 % predhodnega odmerka (obehpemetrekseda in cisplatina)
English: Therefore, the use of pemetrexed in patients with creatinine clearance of <45 ml/min is not recommended (see section 4.2).
Slovenian: Zato uporabe pemetrekseda pri bolnikih z očistkom kreatinina < 45 ml/min ne priporočamo (glejte poglavje 4.2).
English: Infectious and non-infectious disorders of the dermis, the hypodermis and/or the subcutaneous tissue have been reported with an unknown frequency (e.g. acute bacterial dermo-hypodermitis, pseudocellulitis, dermatitis).
Slovenian: Poročali so o nalezljivih in nenalezljivih boleznih dermisa, hipodermisa in/ali podkožja z neznano pogostnostjo (npr. akutni bakterijski dermohipodermitis, psevdocelulitis, dermatitis).
English: If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), pemetrexed should be withheld until resolution to less than or equal to the patient's pre-therapy value.
Slovenian: Če se pri bolnikih razvijejo nehematološke toksičnosti ≥ stopnje 3 (z izjemo nevrološke toksičnosti), moramo dajanje pemetrekseda prekiniti, dokler se vrednosti ne povrnejo na manjše ali enake, kot jih je imel bolnik pred zdravljenjem.
English: Contact your doctor if you get a severe rash, or itching, or blistering (Stevens-Johnson syndrome or toxic epidermal necrolysis).
Slovenian: Obvestite svojega zdravnika, če se pojavijo hud izpuščaj, srbenje ali mehurčki (Stevens-Johnsonov sindrom ali toksična epidermalna nekroliza).
English: Corticosteriods: your doctor will prescribe you steroid tablets (equivalent to 4 milligram of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after Pemetrexed Pfizer treatment.
Slovenian: Kortikosteroidi: vaš zdravnik vam bo predpisal tablete steroidov (ustrezno 4 miligramom deksametazona dvakrat dnevno), ki jih boste morali jemati dan pred zdravljenjem z zdravilom Pemetreksed Pfizer, na dan zdravljenja in na dan po zdravljenju z zdravilom Pemetreksed Pfizer.
English: The incidence of adverse reactions was evaluated for patients who received ≤6 cycles of pemetrexed maintenance (N=519), and compared to patients who received >6 cycles of pemetrexed (N=281).
Slovenian: Pojavnost neželenih učinkov so ocenili za bolnike, ki so prejeli ≤ 6 ciklov vzdrževalnega zdravljenja s pemetreksedom (N=519) in jo primerjali z bolniki, ki so prejeli > 6 ciklov pemetrekseda (N=281).
English: Pre-treatment with dexamethasone (or equivalent) can reduce the incidence and severity of skin reactions (see section
Slovenian: Predhodno zdravljenje z deksametazonom (ali drugim ustreznim kortikosteroidom) lahko zmanjša incidenco in resnost kožnih reakcij (glejte poglavje 4.2).
English: AST (SGOT) elevation
Slovenian: SGOT (AST)
English: A subgroup analysis was performed on patients who received folic acid and vitamin B12 supplementation during the entire course of study therapy (fully supplemented).
Slovenian: Analizo podskupin so opravili pri bolnikih, ki so prejemali dopolnilna folno kislino in vitamin B12 celoten čas trajanja zdravljenja v študiji (popolno dopolnjevanje).
English: Administration of pemetrexed to male mice resulted in reproductive toxicity characterised by reduced fertility rates and testicular atrophy.
Slovenian: Dajanje pemetrekseda mišjim samcem je povzročilo reproduktivno toksičnost z nižjimi stopnjami plodnosti ter atrofijo testisov.
English: Cisplatin is also given by infusion into one of your veins, and is given approximately 30 minutes after the infusion of Pemetrexed Pfizer has finished.
Slovenian: Cisplatin ravno tako dajemo v obliki infuzije v veno, približno 30 minut po zaključku infuzije zdravila Pemetreksed Pfizer.
English: If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with Pemetrexed Pfizer.
Slovenian: Če ste bili nedavno cepljeni, prosimo, da o tem obvestite zdravnika, saj lahko to ob uporabi zdravila Pemetreksed Pfizer povzroča škodljive učinke.
English: Owing to the possibility of pemetrexed treatment causing irreversible infertility (see section 5.3), men are advised to seek counselling on sperm storage before starting treatment.
Slovenian: Zaradi možnosti, da zdravljenje s pemetreksedom povzroči trajno neplodnost (glejte poglavje 5.3), naj se moški pred začetkom zdravljenja posvetujejo o shranjevanju sperme.
English: Blood clots in the lung blood vessels (pulmonary embolism)
Slovenian: Krvni strdki v krvnih žilah v pljučih (pljučna embolija)
English: Rare cases of anaphylactic shock have been reported.
Slovenian: Poročali so o redkih primerih anafilaktičnega šoka.
English: There is not a specific antidote for extravasation of pemetrexed.
Slovenian: Za ekstravazacijo pemetrekseda ni specifičnega antidota.
English: Hyperpigmentation has been commonly reported.
Slovenian: Pogosto so poročali o hiperpigmentaciji.
English: To reduce toxicity, patients treated with pemetrexed must also receive vitamin supplementation (see section 4.4).
Slovenian: Za zmanjšanje toksičnosti moramo bolnikom, ki jih zdravimo s pemetreksedom, dati tudi dopolnila vitaminov (glejte poglavje 4.4).
English: Therefore, caution should be made when administering higher doses of NSAIDs or acetylsalicylic acid, concurrently with pemetrexed to patients with normal function (creatinine clearance ≥ 80 ml/min).
Slovenian: Zato je pri dajanju visokih odmerkov NSAID-ov ali acetilsalicilne kisline sočasno s pemetreksedom bolnikom z normalnim delovanjem ledvic (očistek kreatinina ≥ 80 ml/min) potrebna previdnost.
English: Cases of radiation recall have been reported in patients who received radiotherapy weeks or years previously.
Slovenian: Poročali so o radiacijskem izpuščaju pri bolnikih, ki so se zdravili z radioterapijo pred tedni ali leti.
English: Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells.
Slovenian: Poliglutamirani presnovki imajo podaljšani znotrajcelični razpolovni čas, kar povzroči podaljšano delovanje zdravila v malignih celicah.
English: There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore, the use of pemetrexed is not recommended (see section 4.4).
Slovenian: O uporabi pemetrekseda pri bolnikih z očistkom kreatinina, nižjim od 45 ml/min, ni zadostnih podatkov; zato uporabe pemetrekseda ne priporočamo (glejte poglavje 4.4).
English: These differences were likely due to differences in the patient population, since the Phase 2 studies included both chemonaive and heavily pre-treated breast cancer patients with pre-existing liver metastases and/or abnormal baseline liver function tests.
Slovenian: Te razlike so bile verjetno posledica različnih populacij bolnikov, saj so v študijah faze 2 sodelovali bolniki, ki še niso prejemali kemoterapije, in tudi bolnice s karcinomom dojke, ki so v preteklosti prejemale kemoterapijo, s predhodno obstoječimi metastazami v jetrih in/ali nenormalnimi izhodiščnimi vrednostmi testov jetrnega delovanja.
English: Fast heart rate
Slovenian: Hiter srčni utrip
English: Pemetrexed Pfizer is a medicine used in the treatment of cancer.
Slovenian: Pemetreksed Pfizer je zdravilo, ki ga uporabljamo pri zdravljenju raka.
English: Superio rity pvalue pemetrexed + cisplatin gemcitabine + cisplatin
Slovenian: Prednost pvrednost pemetreksed + cisplatin gemcitabin + cisplatin
English: ITT population (N = 1725)
Slovenian: NZ populacija (N = 1725)
English: Interactions common to all cytotoxics
Slovenian: Medsebojna delovanja, ki so skupna vsem citotoksičnim zdravilom
English: Patients received a median of 4 cycles of maintenance treatment with pemetrexed and 4 cycles of placebo.
Slovenian: Bolniki so prejeli mediano 4 cikle vzdrževalnega zdravljenja s pemetreksedom in 4 cikle placeba.
English: ***Integrated adverse reactions table combines the results of the JMEN pemetrexed maintenance (N=663) and PARAMOUNT continuation pemetrexed maintenance (N=539) studies.
Slovenian: ***Skupna preglednica neželenih učinkov združuje rezultate študij vzdrževalnega zdravljenja samo s pemetreksedom JMEN (N=663) in nadaljevalnega zdravljenja s pemetreksedom (PARAMOUNT: N=539).
English: Do not use this medicine after the expiry date which is stated on the carton and label after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in nalepki poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Loss of sensation
Slovenian: Izguba občutka
English: Concomitant administration of substances that are also tubularly secreted (e.g., probenecid, penicillin) could potentially result in delayed clearance of pemetrexed.
Slovenian: Sočasno dajanje snovi, ki se tudi izločajo s tubulno sekrecijo (denimo, probenecid, penicilin), lahko potencialno povzroči zakasnjeni očistek pemetrekseda.
English: Of the 939 patients treated with pemetrexed plus cisplatin induction, 539 patients were randomised to maintenance treatment with pemetrexed or placebo.
Slovenian: Izmed 939 bolnikov, ki so bili zdravljeni s pemetreksedom in indukcijskim zdravilom cisplatina, je bilo naključno izbranih za vzdrževalno zdravljenje s pemetreksedom ali s placebom.
English: Other undesirable effects include renal toxicities, increased aminotransferases, alopecia, fatigue, dehydration, rash, infection/sepsis and neuropathy.
Slovenian: Drugi neželeni učinki vključujejo toksičnost za ledvice, povišane aminotransferaze, alopecijo, utrujenost, dehidracijo, izpuščaj, okužbo/sepso in nevropatijo.
English: The relative treatment effect of pemetrexed was internally consistent across subgroups (including disease stage, induction response, ECOG PS, smoking status, gender, histology and age) and similar to that observed in the unadjusted OS and PFS analyses.
Slovenian: Relativni učinek zdravljenja s pemetreksedom je bil notranje konsistenten med podskupinami (vključno s stopnjo bolezni, odzivom na indukcijsko zdravljenje, stanjem zmogljivosti po ECOG, kajenjem, spolom, histologijo in starostjo) in podoben tistemu, ki so ga opazili pri neprilagojenih analizah skupnega preživetja in preživetja brez napredovanja bolezni.
English: Uncommon cases of peripheral ischaemia leading sometimes to extremity necrosis have been reported.
Slovenian: Poročali so o občasnih primerih periferne ishemije, ki je včasih vodila v nekrozo okončin.
English: A Phase 2 study of pemetrexed in 31 solid tumour patients with stable third-space fluid demonstrated no difference in pemetrexed dose normalised plasma concentrations or clearance compared to patients without third-space fluid collections.
Slovenian: V študiji pemetrekseda so v fazi II pri 31 bolnikih s solidnim tumorjem in stabilno tekočino tretjega prostora pokazali, da ni razlike med normalno koncentracijo v plazmi ali očistkom, doseženo glede na odmerek pemetrekseda, v primerjavi z bolniki brez zaloge tekočine tretjega prostora.
English: Concomitant use contraindicated Yellow fever vaccine: Risk of fatal generalised vaccinale disease (see section 4.3).
Slovenian: Kontraindicirana sočasna uporaba Cepivo proti rumeni mrzlici: tveganje za smrtno generalizirano bolezen po cepljenju (glejte poglavje
English: Single use only SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children.
Slovenian: POSEBNO OPOZORILO O SHRANJEVANJU ZDRAVILA ZUNAJ DOSEGA IN POGLEDA OTROK
English: Concomitant yellow fever vaccine (see section 4.5).
Slovenian: Sočasno cepljenje proti rumeni mrzlici (glejte poglavje 4.5).
English: There were no clinically relevant differences observed for the safety profile of pemetrexed within the histology subgroups.
Slovenian: Za varnostni profil pemetrekseda niso opazili nobenih klinično pomembnih razlik znotraj histoloških podskupin.
English: Therefore, patients should receive adequate anti-emetic treatment and appropriate hydration prior to and/or after receiving treatment.
Slovenian: Zato moramo bolnike pred prejemanjem terapije in/ali po njej ustrezno hidrirati, prejeti morajo zadostno antiemetično zdravljenje.
English: Reconstituted and infusion solutions: When prepared as directed, chemical and physical in-use stability has been demonstrated for 24 hours at refrigerated temperature (2°C to 8°C) and at 25°C.
Slovenian: Rekonstituirane raztopine in raztopine za infundiranje: Če je zdravilo pripravljeno skladno z navodili, so kemijsko in fizikalno obstojnost zdravila med uporabo dokazali za 24 ur pri temperaturi shranjevanja v hladilniku (2°C do 8°C) in pri temperaturi 25 °C.
English: Clinically relevant Grade 3 and Grade 4 laboratory toxicities were similar between integrated Phase 2 results from three single-agent pemetrexed studies (N = 164) and the Phase 3 single-agent pemetrexed study described above, with the exception of neutropenia (12.8% versus 5.3%, respectively) and alanine aminotransferase elevation (15.2% versus 1.9%, respectively).
Slovenian: Klinično pomembne laboratorijske toksičnosti stopenj 3 in 4 so bile podobne pri integriranih rezultatih faze 2 treh študij pemetrekseda kot edine učinkovine (n = 164) in faze 3 študije pemetrekseda kot edine učinkovine, opisane zgoraj, z izjemo nevtropenije (12,8 % oziroma 5,3 %) in povišanja alaninske aminotransferaze (15,2 % oziroma 1,9 %).
English: However, patients with hepatic impairment, such as bilirubin > 1.5times the upper limit of normal and/or aminotransferase > 3.0-times the upper limit of normal (hepatic metastases absent) or > 5.0 times the upper limit of normal (hepatic metastases present), have not been specifically studied.
Slovenian: Vendar pa bolnikov z okvarjenim delovanjem jeter, ki se kaže kot bilirubin > 1,5-kratnik zgornje meje normalnih vrednosti in/ali aminotransferaza > 3,0-kratnik zgornje meje normalnih vrednosti (brez zasevkov v jetrih) ali > 5,0-kratnik zgornje meje normalnih vrednosti (z zasevki v jetrih), niso posebej preučevali.
English: Other (N = 252)
Slovenian: Drugo (N = 252)
English: Patients must take oral folic acid or a multivitamin containing folic acid (350 to 1,000 micrograms) on a daily basis.
Slovenian: Bolniki morajo dnevno jemati peroralno folno kislino ali multivitaminski pripravek, ki jo vsebuje (350 do 1.000 mikrogramov).
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1,000 micrograms) that you must take once a day while you are taking Pemetrexed Pfizer.
Slovenian: Dopolnjevanje vitaminov: vaš zdravnik vam bo predpisal peroralno folno kislino (vitamin) ali multivitaminski pripravek, ki jo vsebuje (350 do 1.000 mikrogramov), ki ga boste morali med prejemanjem zdravila Pemetreksed Pfizer jemati enkrat dnevno.
English: Common ALT (SGPT) elevation
Slovenian: Pogosto Povišanje SGPT (ALT) Povišanje
English: Discard unused contents appropriately
Slovenian: Neuporabljeno vsebino ustrezno zavrzite.
English: What Pemetrexed Pfizer is and what it is used for
Slovenian: Kaj je zdravilo Pemetreksed Pfizer in za kaj ga uporabljamo
English: Pemetrexed Pfizer must only be further diluted with 5% glucose solution, without preservative.
Slovenian: Zdravilo Pemetreksed Pfizer moramo še nadalje redčiti samo s 5-odstotno raztopino glukoze brez konzervansa.
English: The independent review of patient scans confirmed the findings of the investigator assessment of PFS.
Slovenian: Neodvisni pregled posnetkov bolnikov je potrdil izsledke ocen preživetja brez napredovanja s strani raziskovalca.
English: The reconstituted solution is clear and ranges in colour from colourless to yellow or green-yellow without adversely affecting product quality.
Slovenian: Rekonstituirana raztopina je bistra, brezbarvna do rumena ali zeleno-rumena, barve v tem razponu ne vplivajo na kakovost zdravila.
English: As with other potentially toxic anti-cancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions.
Slovenian: Kot pri drugih potencialno toksičnih učinkovinah za zdravljenje raka je potrebna previdnost pri ravnanju z raztopinami pemetrekseda za infundiranje ter pripravi teh raztopin.
English: Pemetrexed Pfizer can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Slovenian: Zdravnik vam lahko predpiše zdravilo Pemetreksed Pfizer, če imate pljučnega raka v napredovalem stadiju in če se vaša bolezen odziva na zdravljenje oz. če po začetni kemoterapiji ostaja večinoma nespremenjena.
English: Patients randomised to maintenance treatment were required to have an ECOG performance status 0 or 1.
Slovenian: Bolniki, ki so bili naključno izbrani za vzdrževalno zdravljenje so morali imeti indeks zmogljivosti po ECOG 0 ali 1.
English: Owing to the possibility of pemetrexed treatment causing irreversible infertility, men are advised to seek counselling on sperm storage before starting treatment.
Slovenian: Zaradi možnosti, da zdravljenje s pemetreksedom povzroči trajno neplodnost, naj se moški pred začetkom zdravljenja posvetujejo o shranjevanju semena.
English: • Response rate (%) (95% CI)
Slovenian: • Stopnja odzivnosti (%) (95% IZ)
English: Due to the gastrointestinal toxicity of pemetrexed given in combination with cisplatin, severe dehydration has been observed.
Slovenian: Kot posledico toksičnosti pemetrekseda v kombinaciji s cisplatinom za prebavila so opažali hudo dehidracijo.
English: Rare cases of bullous conditions have been reported including Stevens-Johnson syndrome and Toxic epidermal necrolysis which in some cases were fatal.
Slovenian: Poročali so o redkih primerih buloznih stanj, kot sta Stevens-Johnsonov sindrom in toksična epidermalna nekroliza, ki so bila v nekaterih primerih usodna.
English: The appropriate volume of reconstituted pemetrexed solution must be further diluted to 100 ml with 5% glucose solution for injection, without preservative, and administered as an intravenous infusion over 10 minutes.
Slovenian: Ustrezno prostornino rekonstituirane raztopine pemetrekseda moramo še nadalje redčiti do 100 ml s 5-odstotno raztopino glukoze za injiciranje brez konzervansa; damo jo kot intravensko infuzijo, ki teče 10 minut.
English: Uncommon cases of acute renal failure have been reported with pemetrexed alone or in association with other chemotherapeutic agents (see section 4.4).
Slovenian: Poročali so o občasnih primerih akutne odpovedi ledvic s pemetreksedom samim ali v povezavi z drugimi kemoterapevtiki (glejte poglavje 4.4).
English: At least five doses of folic acid must be taken during the seven days preceding the first dose of pemetrexed, and dosing must continue during the full course of therapy and for 21 days after the last dose of pemetrexed.
Slovenian: V sedmih dneh pred prvim odmerkom pemetrekseda morajo vzeti vsaj pet odmerkov folne kisline, odmerjanje pa morajo nadaljevati ves čas zdravljenja in še 21 dni po zadnjem odmerku pemetrekseda.
English: For instructions on reconstitution and dilution of Pemetrexed Pfizer before administration, see section 6.6
Slovenian: Za informacije o rekonstituciji in redčenju zdravila Pemetreksed Pfizer pred uporabo glejte poglavje 6.6.
English: Patients receiving pemetrexed should be monitored before each dose with a complete blood count, including a differential white cell count (WCC) and platelet count.
Slovenian: Bolnikom, ki prejemajo pemetreksed, moramo pred vsakim odmerkom odvzeti kri za popolno krvno sliko, vključno z diferencialno belo krvno sliko (WCC) in številom trombocitov.
English: Administration of pemetrexed to pregnant mice resulted in decreased foetal viability, decreased foetal weight, incomplete ossification of some skeletal structures, and cleft palate.
Slovenian: Dajanje pemetrekseda brejim mišim je povzročilo zmanjšano preživetje plodov, zmanjšano maso plodov, nepopolno okostenevanje določenih struktur okostja in shize neba.
English: Limited clinical data from a separate randomised, Phase-3, controlled trial, suggest that efficacy data (overall survival, progression-free survival) for pemetrexed are similar between patients previously pre-treated with docetaxel (N = 41) and patients who did not receive previous docetaxel treatment (N =
Slovenian: Omejeni klinični podatki iz ločeno randomiziranih, kontroliranih preskušanj faze 3, nakazujejo, da so podatki o učinkovitosti (skupno preživetje, preživetje brez napredovanja) za pemetreksed podobni med bolniki, ki so bili predhodno zdravljeni z doksatakselom (n = 41) in bolniki, ki niso prejeli predhodnega zdravljenja z doksatakselom (n = 540).
English: Oral folic acid and intramuscular vitamin B12 supplementation do not affect the pharmacokinetics of pemetrexed.
Slovenian: Peroralno jemanje folne kisline in intramuskularno dopolnjevanje z vitaminom B12 ne vplivata na farmakokinetiko pemetrekseda.
English: Any unused medicinal product or waste material must be disposed of in accordance with local requirements.
Slovenian: Neporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
English: Dose for cisplatin (mg/m2)
Slovenian: Odmerek cisplatina (mg/m
English: First-line doublet therapy containing pemetrexed was not included.
Slovenian: Dvojne terapije prvega izbora s pemetreksedom niso vključili.
English: Before the start of any cycle of chemotherapy, patients are required to have the following: absolute neutrophil count (ANC) should be ≥ 1,500 cells/mm3 and platelets should be ≥ 100,000 cells/mm3.
Slovenian: Pred začetkom kateregakoli ciklusa kemoterapije morajo bolniki izpolnjevati naslednja merila: absolutno število nevtrofilcev (ANC) mora biti ≥ 1500 celic/mm
English: Grade 3-4 toxicity
Slovenian: Toksičnost stopnje 3-4