FrancophonIA/ELRC3.0 huggingface dataset:
English: These reactions occur usually at the beginning of the treatment and can occur after a single administration.
Slovenian: Te reakcije se običajno pojavijo na začetku zdravljenja in se lahko pojavijo tudi po enem odmerku.
English: Metoclopramide may decrease digoxin bioavailability.
Slovenian: Metoklopramid lahko zmanjša biološko razpoložljivost digoksina.
English: What Tradename is and what it is used for
Slovenian: Kaj je zdravilo Xyz in za kaj ga uporabljamo
English: Extrapyramidal disorders may occur, particularly in children and young adults, and/or when high doses are used.
Slovenian: Lahko se pojavijo ekstrapiramidne motnje, zlasti pri otrocih in mladostnikih in/ali pri uporabi velikih odmerkov.
English: Careful monitoring of cyclosporine plasma concentration is required.
Slovenian: Potrebno je pozorno spremljanje plazemskih koncentracij ciklosporina.
English: In adults patients
Slovenian: Pri odraslih bolnikih
English: Central nervous system depressants (morphine derivatives, anxiolytics, sedative H1 antihistamines, sedative antidepressants, barbiturates, clonidine and related) Sedative effects of Central Nervous System depressants and metoclopramide are potentiated.
Slovenian: Zaviralci osrednjega živčnega sistema (derivati morfina, anksiolitiki, sedativni H1 antihistaminiki, sedativni antidepresivi, barbiturati, klonidin in sorodne učinkovine) Sedativni učinki zaviralcev osrednjega živčnega sistema in metoklopramida se potencirajo.
English: In patients with cirrhosis of the liver, accumulation of metoclopramide has been observed, associated with a 50% reduction in plasma clearance.
Slovenian: Pri bolnikih s cirozo jeter so opazili kopičenje metoklopramida, povezanega s 50 % zmanjšanjem plazemskega očistka.
English: Adults with liver problems
Slovenian: Odrasli s težavami z jetri
English: The clearance of metoclopramide is reduced by up to 70% in patients with severe renal impairment, while the plasma elimination half-life is increased (approximately 10 hours for a creatinine clearance of 10-50 mL/minute and 15 hours for a creatinine clearance <10 mL/minute).
Slovenian: Pri bolnikih s hudo okvarjenim delovanjem ledvic je očistek metoklopramida nižji za do 70 %, medtem ko je plazemski razpolovni čas izločanja podaljšan (približno 10 ur za kreatininski očistek 10-50 ml/minuto in 15 ur za kreatininski očistek <10 ml/minuto).
English: Children and adolescents Metoclopramide must not be used in children aged less than 1 year (see section 2).
Slovenian: Uporaba pri otrocih in mladostnikih Metoklopramida se ne sme uporabljati pri otrocih, mlajših od 1 leta (glejte poglavje 2).
English: Children and adolescents For all formulations
Slovenian: Otroci in mladostniki Za vse farmacevtske oblike
English: The dose may be reduced (see section 3).
Slovenian: Morda bo potrebno zmanjšanje odmerka (glejte poglavje
English: Combination to be avoided Alcohol potentiates the sedative effect of metoclopramide.
Slovenian: Kombinacija, ki se ji je treba izogniti Alkohol okrepi sedativni učinek metoklopramida.
English: If you have any further questions on the use of this medicine, ask your doctor, nurse or pharmacist.
Slovenian: Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom, medicinsko sestro ali s farmacevtom.
English: Careful monitoring of digoxin plasma concentration is required.
Slovenian: Potrebno je pozorno spremljanje plazemskih koncentracij digoksina.
English: In cases of abnormal levels (methaemoglobinemia), the treatment should be immediately and permanently stopped.
Slovenian: V primerih nenormalnih koncentracij (methemoglobinemija) je treba zdravljenje takoj in trajno prekiniti.
English: * Endocrine disorders during prolonged treatment in relation with hyperprolactinaemia (amenorrhoea, galactorrhoea, gynaecomastia).
Slovenian: * Bolezni endokrinega sistema med dolgotrajnim zdravljenjem v povezavi s hiperprolaktinemijo (amenoreja, galaktoreja, ginekomastija).
English: Intravenous doses should be administered as a slow bolus (at least over 3 minutes) in order to reduce the risk of adverse effects (e.g. hypotension, akathisia).
Slovenian: Intravenske odmerke je treba injicirati počasi v bolusu (najmanj 3 minute), da bi zmanjšali tveganje za neželene učinke (npr. hipotenzija, akatizija).
English: It works on a part of your brain that prevents you from feeling sick (nausea) or being sick (vomiting).
Slovenian: Deluje tako, da vpliva na del vaših možganov, ki preprečuje občutek slabosti ali bruhanja.
English: In elderly patients a dose reduction should be considered, based on renal and hepatic function and overall frailty.
Slovenian: Pri starejših bolnikih je treba razmisliti o zmanjšanju odmerka, glede na njihovo delovanje ledvic in jeter ter splošno oslabelost.
English: {Tradename} is used in children (aged 1-18 years) only if other treatment does not work or cannot be used:
Slovenian: Zdravilo Xyz se pri otrocih (starih 1 do 18 let) uporablja zgolj, če druge oblike zdravljenja niso učinkovite ali jih ni mogoče uporabiti za:
English: The solution can be administered intravenously or intramuscularly.
Slovenian: Raztopino lahko dajemo intravensko ali intramuskularno.
English: Prolonged treatment with metoclopramide may cause tardive dyskinesia, potentially irreversible, especially in the elderly.
Slovenian: Pri dolgotrajnem zdravljenju z metoklopramidom se lahko pojavi tardivna diskinezija, ki je potencialno nepovratna, zlasti pri starejših bolnikih.
English: These movements will stop when when treated appropriately.
Slovenian: Ti gibi bodo izginili po ustreznem zdravljenju.
English: Metoclopramide should be avoided at the end of pregnancy.
Slovenian: Ob koncu nosečnosti se je treba izogniti uporabi metoklopramida.
English: - Use in children less than 1 year of age due to an increased risk of extrapyramidal disorders (see section 4.4)
Slovenian: - Uporaba pri otrocih starih manj kot 1 leto, zaradi povečanega tveganja ekstrapiramidnih motenj (glejte poglavje 4.4).
English: Common Extrapyramidal disorders (particularly in children and young adults and/or when the recommended dose is exceeded, even following administration of a single dose of the drug) (see section 4.4), Parkinsonism, Akathisia
Slovenian: Pogosti ekstrapiramidne motnje (zlasti pri otrocih in mladostnikih in/ali ko je presežen priporočeni odmerek, tudi po uporabi zgolj enega odmerka zdravila) (glejte poglavje 4.4), parkinsonizem, akatizija
English: Special care should be taken when administering metoclopramide, particularly via the intravenous route to the elderly population, to patients with cardiac conduction disturbances (including QT prolongation), patients with uncorrected electrolyte imbalance, bradycardia and those taking other drugs known to prolong QT interval.
Slovenian: Posebna previdnost pri uporabi metoklopramida je potrebna pri intravensnki uporabi pri starejših bolnikih, pri bolnikih z motnjami srčnega prevajanja (vključno s podaljšanim intervalom QT), bolnikih z nekorigiranimi neravnovesji elektrolitov, bradikardijo in pri tistih, ki jemljejo druga zdravila, ki podaljšajo interval QT.
English: This medicine must not be used in children below 1 year of age because of the increased risk of the uncontrollable movements (see above “Do not take {Tradename} if”).
Slovenian: Tega zdravila se ne sme uporabljati pri otrocih, mlajših od 1 leta, zaradi povečanega tveganja za pojav nenadzorovanih gibov (glejte zgoraj »Ne jemljite zdravila Xyz«).
English: - Drowsiness, decreased level of consciousness, confusion, hallucination.
Slovenian: - Zaspanost, zmanjšana stopnja zavesti, zmedenost, halucinacije.
English: The following wording should be included in the SmPC of the marketing authorisations to be varied, as relevant:
Slovenian: Sledeče besedilo mora biti vključeno v Povzetek glavnih značilnosti zdravila dovoljenj za promet, ki jih je treba spremeniti, in sicer če je potrebno:
English: Special care should be exercised in patients with underlying neurological conditions and in patients being treated with other centrally-acting drugs (see section 4.3)
Slovenian: Posebna previdnost je potrebna pri bolnikih z obstoječimi nevrološkimi motnjami in pri bolnikih, ki se zdravijo z drugimi osrednje delujočimi zdravili (glejte poglavje 4.3).
English: There have been reports of serious cardiovascular undesirable effects including cases of circulatory collapse, severe bradycardia, cardiac arrest and QT prolongation following administration of metoclopramide by injection, particularly via the intravenous route (see section 4.8).
Slovenian: Poročali so o pojavu resnih srčno-žilnih neželenih učinkov, vključno s primeri cirkulacijskega kolapsa, hude bradikardije, srčnega zastoja in podaljšanja intervala QT po injiciranju metoklopramida, zlasti pri intravenski uporabi (glejte poglavje 4.8).
English: Parenteral route/IM-IV
Slovenian: Parenteralna uporaba/i.m.-i.v.
English: The following reactions, sometimes associated, occur more frequently when high doses are used: - Extrapyramidal symptoms: acute dystonia and dyskinesia, parkinsonian syndrome, akathisia, even following administration of a single dose of the medicinal product, particularly in children and young adults (see section 4.4).
Slovenian: Sledeče reakcije, ki so včasih povezane, se pojavljajo bolj pogosto pri uporabi velikih odmerkov: - Ekstrapiramidni simptomi: akutna distonija in diskinezija, parkinsonski sindrom, akatizija, tudi po uporabi zgolj enega odmerka zdravila, zlasti pri otrocih in mladostnikih (glejte poglavje
English: In patients with end stage renal disease (Creatinine clearance ≤ 15 ml/min), the daily dose should be reduced by 75%.
Slovenian: Pri bolnikih s končno odpovedjo ledvic (kreatininski očistek ≤ 15 ml/min), je treba dnevni odmerek zmanjšati za 75 %.
English: Metoclopramide may cause drowsiness, dizziness, dyskinesia and dystonias which could affect the vision and also interfere with the ability to drive and operate machinery.
Slovenian: Metoklopramid lahko povzroči zaspanost, omotico, diskinezijo in distonijo, kar lahko vpliva na vid ter na sposobnost vožnje in upravljanja s stroji.
English: <Other pharmaceutical forms/strengths may be more appropriate for administration> <This formulation is not suitable for administration>
Slovenian: <Druge farmacevtske oblike/jakosti bodo morda bolj primerne za uporabo> <Ta farmacevtska oblika ni primerna za uporabo>
English: Blood and lymphatic system disorders Not known Methaemoglobinaemia, which could be related to NADH cytochrome b5 reductase deficiency, particularly in neonates (see section 4.4)
Slovenian: Bolezni krvi in limfatičnega sistema Neznana methemoglobinemija, ki je lahko povezana s pomanjkanjem encima NADH citokrom b5 reduktaze, zlasti pri novorojenčkih (glejte poglavje 4.4);
English: Anticholinergics and morphine derivatives may have both a mutual antagonism with metoclopramide on the digestive tract motility.
Slovenian: Antiholinergiki in derivati morfina ob sočasni uporabi z metoklopramidom lahko delujejo medsebojno antagonistično na motiliteto prebavnega trakta.
English: Metoclopramide is excreted in breast milk at low level.
Slovenian: Metoklopramid se izloča v materino mleko v majhnih količinah.
English: Talk to your doctor if you have kidney problems.
Slovenian: Posvetujte se s svojim zdravnikom, če imate težave z ledvicami.
English: Not known Tardive dyskinesia which may be persistent, during or after prolonged treatment, particularly in elderly patients (see section 4.4), Neuroleptic malignant syndrome (see section 4.4)
Slovenian: Neznana tardivna diskinezija, ki je lahko trdovratna, med in po dolgotrajnem zdravljenju, zlasti pri starejših bolnikih (glejte poglavje 4.4); nevroleptični maligni sindrom (glejte poglavje
English: In patients with renal impairment or with severe hepatic impairment, a dose reduction is recommended (see section 4.2).
Slovenian: Pri bolnikih z okvarjenim delovanjem ledvic ali s hudo okvarjenim delovanjem jeter, se priporoča zmanjšanje odmerka (glejte poglavje 4.2).
English: In case of extrapyramidal symptoms related or not to overdose, the treatment is only symptomatic (benzodiazepines in children and/or anticholinergic anti-parkinsonian medicinal products in adults).
Slovenian: V primeru pojava ekstrapiramidnih simptomov, povezanih s prevelikim odmerjanjem ali ne, je zdravljenje zgolj simptomatsko (z benzodiazepini pri otrocih in/ali antiholinergičnimi antiparkinsoniki pri odraslih).
English: Very common (may affect more than 1 in 10 people) feeling drowsy.
Slovenian: Zelo pogosti (pojavijo se lahko pri več kot 1 od 10 bolnikov) • občutek zaspanosti;
English: Do not take {Tradename} if: For all formulations
Slovenian: Ne jemljite zdravila Xyz: Za vse farmacevtske oblike
English: Serotonergic drugs
Slovenian: Serotonergična zdravila
English: Other pharmaceutical forms/strengths may be more appropriate for administration.
Slovenian: Druge farmacevtske oblike/jakosti so lahko bolj primerne za uporabo pri tej populaciji.
English: For immediate release oral formulations
Slovenian: Za pripravke s takojšnjim sproščanjem
English: For the prevention of nausea and vomiting that may occur after surgery prevention: a single dose of 10mg is recommended.
Slovenian: Za preprečevanje slabosti in bruhanja, ki lahko nastopita po operativnih posegih: priporočen je enkratni 10 mg odmerek.
English: The recommended dose is 30mg once daily.
Slovenian: Priporočeni odmerek je 30 mg enkrat na dan.
English: You should not take this medicine for more than 5 days to prevent delayed nausea and vomiting that may occur after chemotherapy.
Slovenian: Tega zdravila ne smete jemati več kot 5 dni za preprečevanje zakasnele, s kemoterapijo povzročene slabosti in bruhanja.
English: Methaemoglobinemia
Slovenian: Methemoglobinemija
English: If necessary, {Tradename} may be taken during pregnancy.
Slovenian: Če je potrebno, se zdravilo Xyz lahko jemlje med nosečnostjo.
English: These effects are generally completely reversible after treatment discontinuation, but may require a symptomatic treatment (benzodiazepines in children and/or anticholinergic anti-Parkinsonian medicinal products in adults).
Slovenian: Ti neželeni učinki običajno popolnoma izginejo po prekinitvi zdravljenja, lahko pa bo potrebno simptomatsko zdravljenje (z benzodiazepini pri otrocih in/ali antiholinergičnimi antiparkinsoniki pri odraslih).
English: Adults with kidney problems
Slovenian: Odrasli s težavami z ledvicami
English: mainly with concomitant administration of high doses of sulphur-releasing medicinal products
Slovenian: sulfhemoglobinemija, predvsem s sočasno uporabo velikih odmerkov zdravil, ki sproščajo žveplo;
English: Not known Shock, syncope after injectable use Acute hypertension in patients with phaeochromocytoma (see section 4.3)
Slovenian: Neznana šok, omedlevica po injiciranju zdravila; akutna hipertenzija pri bolnikih s feokromocitomom (glejte poglavje 4.3)
English: Parenteral route
Slovenian: Parenteralna uporaba
English: Symptoms of Parkinson's disease may also be exacerbated by metoclopramide.
Slovenian: Zdravljenje z metoklopramidom lahko tudi poslabša simptome Parkinsonove bolezni.
English: It will be given as a slow injection into a vein (over at least 3 minutes) or by injection into a muscle.
Slovenian: Prejeli ga boste v obliki počasne intravenske (injiciranje traja najmanj 3 minute) ali intramuskularne injekcije.
English: If you are not sure, talk to your doctor, pharmacist or nurse before you take Tradename.
Slovenian: Če ste negotovi, se posvetujte z zdravnikom, s farmacevtom ali z medicinsko sestro, preden vzamete zdravilo Xyz.
English: In patients with moderate to severe renal impairment (Creatinine clearance 15-60 ml/min), the dose should be reduced by 50% (see section 5.2).
Slovenian: Pri bolnikih z zmerno do hudo okvarjenim delovanjem ledvic (kreatininski očistek 15 do 60 ml/min), je treba dnevni odmerek zmanjšati za 50 % (glejte poglavje 5.2).
English: Adverse reactions listed by System Organ Class.
Slovenian: Neželeni učinki so navedeni po organskih sistemih.
English: Intravenous doses should be administered as a slow bolus (at least over 3 minutes).
Slovenian: Intravenske odmerke je treba injicirati počasi v bolusu ali intramuskularno (najmanj 3 minute).
English: Metoclopramide may have an additive effect with other neuroleptics on the occurrence of extrapyramidal disorders.
Slovenian: Metoklopramid ima skupaj z drugimi nevroleptiki lahko aditiven učinek na pojavnost ekstrapiramidnih motenj.
English: Do not give {Tradename} to a child less than 1 year of age (see below “Children and adolescents”).
Slovenian: Zdravila Xyz se ne sme uporabljati pri otrocih, mlajših od 1 leta (glejte spodaj »Otroci in mladostniki«).
English: Additional statements related to excipients
Slovenian: Dodatne izjave, povezane s pomožnimi snovmi
English: - you are taking levodopa (a medicine for Parkinson's disease) or dopaminergic agonists (see below “Other medicines and Tradename”) - you have ever had an abnormal blood pigment levels (methaemoglobinemia) or NADH cytochromeb5 deficiency
Slovenian: - če imate Parkinsonovo bolezen, - če se zdravite z levodopo (zdravilo za zdravljenje Parkinsonove bolezni) ali dopaminergičnimi agonisti (glejte spodaj »Druga zdravila in zdravilo Xyz«), - če ste v preteklosti imeli nenormalne ravni pigmenta v krvi (methemoglobinemija) ali pomanjkanje encima NADH citokrom b5 reduktaze;
English: Adult population
Slovenian: Odrasli
English: Neuroleptic malignant syndrome has been reported with metoclopramide in combination with neuroleptics as well as with metoclopramide monotherapy (see section 4.8).
Slovenian: Poročali so o pojavu nevroleptičnega malignega sindroma pri zdravljenju z metoklopramidom v kombinaciji z nevroleptiki kot tudi pri monoterapiji z metoklopramidom (glejte poglavje 4.8).
English: Uncommon Dystonia, Dyskinesia, Depressed level of consciousness
Slovenian: Občasni distonija, diskinezija, zmanjšana stopnja zavesti
English: Therefore metoclopramide is not recommended during breastfeeding.
Slovenian: Zato se uporabo metoklopramida v času dojenja odsvetuje.
English: Galactorrhoea Not known Gynaecomastia
Slovenian: Neznana ginekomastija
English: You may experience uncontrollable movements (extrapyramidal disorders), feel drowsy, have some troubles of consciousness, be confused, have hallucination and heart problems.
Slovenian: Pojavijo se lahko nenadzorovani gibi (ekstrapiramidne motnje), občutek zaspanosti, težave z zavestjo, zmedenost, halucinacije in težave s srcem.
English: {Tradename} if”) - anticholinergics (medicines used to relieve stomach cramps or spasms) - morphine derivatives (medicines used to treat severe pain) - sedative medicines - any medicines used to treat mental health problems - digoxin (medicine used to treat heart failure) - cyclosporine (medicine used to treat certain problems with the immune system) - mivacurium and suxamethonium (medicines used to relax muscles)
Slovenian: - derivati morfina (zdravila za lajšanje hudih bolečin), - pomirjevala, - katerakoli zdravila za zdravljenje duševnih motenj, - digoksin (zdravilo za zdravljenje srčnega popuščanja), - ciklosporin (zdravilo, ki se uporablja za zdravljenje določenih težav z imunskim sistemom), - mivakurij in suksametonij (zdravili za sproščanje mišic), - fluoksetin in paroksetin (zdravili za zdravljenje depresije);
English: All routes of administration at the exception prolonged release preparations
Slovenian: Vsi načini uporabe, z izjemo pripravka s podaljšanim sproščanjem Način uporabe:
English: Mivacurium and suxamethonium
Slovenian: Mivakurij in suksametonij
English: 30mg strength
Slovenian: 15 mg jakost
English: Treatment should not exceed 3 months because of the risk of tardive dyskinesia (see section 4.8).
Slovenian: Zaradi tveganja za pojav tardivne diskinezije, zdravljenje ne sme trajati dlje kot 3 mesece (glejte poglavje 4.8).
English: {Tradename} is used in adults:
Slovenian: Zdravilo Xyz se pri odraslih uporablja za:
English: If metoclopramide is used, neonatal monitoring should be undertaken.
Slovenian: V primeru uporabe metoklopramida, je potrebno spremljanje novorojenčka.
English: This is because some medicines can affect the way {Tradename} works or {Tradename} can affect how other medicines work.
Slovenian: To je potrebno zato, ker lahko nekatera zdravila vplivajo na delovanje zdravila Xyz, lahko pa zdravilo Xyz vpliva na delovanje drugih zdravil.
English: Metoclopramide should be discontinued immediately in the event of symptoms of neuroleptic malignant syndrome and appropriate treatment should be initiated.
Slovenian: Če se pojavijo simptomi nevroleptičnega malignega sindroma, je treba zdravljenje z metoklopramidom nemudoma prekiniti ter uvesti ustrezno zdravljenje.
English: Warnings and precautions For all routes of administration
Slovenian: Opozorila in previdnostni ukrepi Velja za vse načine uporabe zdravila.
English: Uncommon Hypersensitivity Not known Anaphylactic reaction (including anaphylactic shock particularly with intravenous formulation
Slovenian: Neznana anafilaktična reakcija (vključno z anafilaktičnim šokom, zlasti pri intravenskih farmacevtskih oblikah)
English: Older people The dose may need to be reduced depending on kidney problems, liver problems and overall health.
Slovenian: Odmerek bo morda potrebno zmanjšati glede na vaše težave z ledvicami ali jetri ter splošno zdravstveno stanje.
English: You may feel drowsy, dizzy or have uncontrollable twitching, jerking or writhing movements and unusual muscle tone causing distortion of the body after taking {Tradename}.
Slovenian: Po jemanju zdravila Xyz se lahko pojavijo zaspanost, omotičnost ali nenadzorovano trzanje, krčeviti gibi ali zvijanje ter nenavaden mišični tonus, kar povzroča deformacijo telesa.
English: {Tradename} is indicated in children (aged 1-18 years) if other treatment does not work or cannot be used to prevent delayed nausea and vomiting that may occur after chemotherapy
Slovenian: Zdravilo Xyz se pri otrocih (starih 1 do 18 let) uporablja, če druge oblike zdravljenja niso učinkovite ali jih ni mogoče uporabiti za preprečevanje zakasnele, s kemoterapijo povzročene slabosti in bruhanja.
English: Neurological Disorders
Slovenian: Nevrološke motnje
English: Metoclopramide is contraindicated in children aged less than 1 year (see section 4.3).
Slovenian: Pediatrična populacija Uporaba metoklopramida pri otrocih, mlajših od 1 leta, je kontraindicirana (glejte poglavje 4.3).
English: Renal impairment:
Slovenian: Okvarjeno delovanje ledvic:
English: Contraindicated combination Levodopa or dopaminergic agonists and metoclopramide have a mutual antagonism (see section 4.3).
Slovenian: Sočasno zdravljenje z metoklopramidom in levodopo ali dopaminergičnimi agonisti je kontraindicirano zaradi medsebojnega antagonizma (glejte poglavje 4.3).
English: - high fever, high blood pressure, convulsions, sweating, production of saliva.
Slovenian: - visoka telesna temperatura, visok krvni tlak, krči, potenje, slinjenje.
English: Talk to your doctor, pharmacist or nurse before taking {Tradename} if: - you have a history of abnormal heart beats (QT interval prolongation) or any other heart problems - you have problems with the levels of salts in your blood, such as potassium, sodium and magnesium.
Slovenian: Pred začetkom jemanja zdravila Xyz se posvetujte z zdravnikom, s farmacevtom ali z medicinsko sestro: - če ste v preteklosti imeli nenormalni srčni utrip (podaljšanje intervala QT) ali katerekoli druge srčne težave, - če imate motnje ravnovesja elektrolitov v krvi, kot so kalij, natrij in magnezij, - če jemljete druga zdravila, za katera je znano, da vplivajo na srčni utrip, - če imate kakršnekoli nevrološke (možganske) težave, - če imate težave z ledvicami ali jetri.
English: - you have epilepsy - you have Parkinson's disease
Slovenian: - Parkinsonova bolezen.
English: Metoclopramide exposure levels are increased when co-administered with strong CYP2D6 inhibitors such as fluoxetine and paroxetine.
Slovenian: Ob sočasni uporabi z močnimi zaviralci CYP2D6, kot sta fluoksetin in paroksetin, se povečajo ravni izpostavljenosti metoklopramidu.
English: For all routes of administration at the exception of prolonged release preparations
Slovenian: Velja za vse načine uporabe zdravila, razen pripravkov s podaljšanim sproščanjem.