FrancophonIA/ELRC3.0 huggingface dataset:
English: Based on interaction studies with the ritonavir boosted protease inhibitors (lopinavir/ritonavir, atazanavir), concurrent administration of omeprazole or ranitidine does not significantly modify ritonavir efficacy as a pharmacokinetic enhancer despite a slight change of exposure (about 6 - 18%).
Croatian: Na temelju ispitivanja interakcija inhibitora proteaza pospješenih ritonavirom (lopinavir/ritonavir, atazanavir), pri istodobnoj primjeni omeprazola ili ranitidina ne mijenja se značajno učinkovitost ritonavira kao farmakokinetičkog pojačivača, unatoč blagoj promjeni izloženosti (za oko 6% - 18%).
English: If you take more Ritonavir Mylan than you should
Croatian: Ako uzmete više lijeka Ritonavir Mylan nego što ste trebali
English: However, because ritonavir has also been shown to inhibit CYP2B6 in vitro, the recommended dose of bupropion should not be exceeded.
Croatian: No kako se pokazalo da ritonavir i inhibira aktivnost CYP2B6 in vitro, ne smije se premašiti preporučena doza bupropiona.
English: Antiasthmatic Theophylline1
Croatian: Antiastmatici Teofilin1
English: The following HIV-1 protease inhibitors have been approved for use with ritonavir as a pharmacokinetic enhancer at the noted doses.
Croatian: Sljedeći su inhibitori proteaza virusa HIV-1 odobreni za primjenu u kombinaciji s ritonavirom kao farmakokinetičkim pojačivačem u navedenim dozama.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to combination antiretroviral therapy (CART).
Croatian: Prijavljeni su slučajevi osteonekroze, osobito u bolesnika s općepoznatim čimbenicima rizika, uznapredovalom HIV-infekcijom i u bolesnika na dugotrajnom kombiniranom antiretrovirusnom liječenju (CART).
English: The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort (see section 4.3).
Croatian: Inducirajući učinak može potrajati najmanje 2 tjedna nakon prekida uzimanja gospine trave (vidjeti dio 4.3).
English: Do not use this medicine after the expiry date on the carton or bottle label after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji ili naljepnici bočice iza oznake „Rok valjanosti”.
English: Induction of CYP1A2 and CYP2C9 lead to decreased levels of R-warfarin while little pharmacokinetic effect is noted on S-warfarin when co-administered with ritonavir.
Croatian: Zbog indukcije CYP1A2 i CYP2C9 snižavaju se razine R-varfarina, dok je na S-varfarin uočen tek slab farmakokinetički učinak pri istodobnoj primjeni s ritonavirom.
English: Ritonavir is a protease inhibitor used to control HIV infection.
Croatian: Ritonavir je inhibitor proteaza koji se koristi za kontrolu HIV-infekcije.
English: Particular caution should be used when prescribing sildenafil or tadalafil for the treatment of erectile dysfunction in patients receiving ritonavir.
Croatian: Poseban je oprez nužan pri propisivanju sildenafila ili tadalafila za liječenje erektilne disfunkcije bolesnicima koji primaju ritonavir.
English: Therefore, the use of ritonavir is not recommended in patients receiving rivaroxaban.
Croatian: Stoga se ne preporučuje primjena ritonavira kod bolesnika koji uzimaju rivaroksaban.
English: Ergot derivatives
Croatian: Derivati ergota
English: For patients who have completed the ramp-up phase and are on a steady daily dose of venetoclax, reduce the venetoclax dose by at least 75% when used with strong CYP3A inhibitors (refer to the venetoclax SmPC for dosing instructions).
Croatian: U bolesnika koji su završili razdoblje povećavanja doze i koji primaju stabilnu dnevnu dozu venetoklaksa, dozu venetoklaksa treba smanjiti za najmanje 75% pri istodobnoj primjeni sa snažnim inhibitorima CYP3A (za upute za doziranje vidjeti Sažetak opisa svojstava lijeka za venetoklaks).
English: The mean average change from baseline over 16 weeks for HIV RNA levels was -0.79 log10 (maximum mean decrease: 1.29 log10) in the ritonavir group versus -0.01 log10 in the control group.
Croatian: Srednja prosječna promjena razina HIV RNA nakon 16 tjedana u odnosu na početno stanje iznosila je −0,79 log10 (maksimalno srednje smanjenje: 1,29 log10) u skupini liječenoj ritonavirom, u usporedbi s −0.01 log10 u kontrolnoj skupini.
English: There are some medicines you cannot take at all with ritonavir.
Croatian: Neke lijekove nikako ne smijete uzimati s ritonavirom.
English: Ritonavir Mylan can cause dizziness.
Croatian: Ritonavir Mylan može izazvati omaglicu.
English: Renal clearance averaged less than 0.1 l/h and was relatively constant throughout the dosage range.
Croatian: Bubrežni je klirens iznosio prosječno manje od 0,1 l/h i bio je razmjerno konstantan u cijelom rasponu doza.
English: Diabetes, as there have been reports of worsening of or the development of diabetes (diabetes mellitus) in some patients taking protease inhibitors.
Croatian: - Šećernu bolest, jer je bilo prijava pogoršanja ili razvoja šećerne bolesti (dijabetes melitus) u nekih bolesnika koji su uzimali inhibitore proteaza.
English: Abdominal pain (upper and lower), nausea, diarrhoea (including severe with electrolyte imbalance), vomiting, dyspepsia
Croatian: Vrlo često Bol u gornjem i donjem abdomenu, mučnina, proljev (uključujući teški proljev s elektrolitskim disbalansom), povraćanje, dispepsija
English: Dose of ritonavir (mg)
Croatian: Doza ritonavira (mg)
English: Increased amylase, decreased free and total thyroxin
Croatian: Povišena vrijednost amilaze, snižene vrijednosti slobodnog i ukupnog tiroksina
English: • inflammation of the liver and yellowing of skin or whites of the eyes
Croatian: • upala jetre i žuta boja kože ili bjeloočnica
English: If treatment with an HMGCoA reductase inhibitor is indicated, pravastatin or fluvastatin is recommended (see section 4.5).
Croatian: Ako je indicirano liječenje inhibitorom HMG-CoA reduktaze, preporučuju se pravastatin ili fluvastatin (vidjeti dio 4.5).
English: Also, the side effects of ritonavir when used with other antiretroviral medicines are dependent on the other medicines.
Croatian: Uz to, nuspojave ritonavira, kada se koristi s drugim antiretrovirusnim lijekovima, ovise i o tim drugim lijekovima.
English: If you realise you have taken more Ritonavir Mylan than you were supposed to, contact your doctor or the Accident and Emergency Department of your nearest hospital straight away.
Croatian: Ako shvatite da ste uzeli više lijeka Ritonavir Mylan nego što je trebalo, javite se odmah svome liječniku ili hitnoj službi najbliže bolnice.
English: If trazodone is co-administered with ritonavir, the combination should be used with caution, initiating trazodone at the lowest dosage and monitoring for clinical response and tolerability.
Croatian: Ako se trazodon daje istodobno s ritonavirom, tu kombinaciju treba davati oprezno, a trazodon treba početi davati u najmanjoj dozi te pratiti klinički odgovor i podnošljivost.
English: Maximal inhibition of metabolism of the co-administered protease inhibitor is generally achieved with ritonavir doses of 100 mg daily to 200 mg twice daily, and is dependent on the co-administered protease inhibitor.
Croatian: Maksimalna inhibicija metabolizma istodobno primijenjenog inhibitora proteaza općenito se postiže dozama ritonavira od 100 mg na dan do 200 mg dva puta na dan i ovisi o istodobno primijenjenom inhibitoru proteaza.
English: Ritonavir-resistant isolates of HIV-1 have been selected in vitro and isolated from patients treated with therapeutic doses of ritonavir.
Croatian: Izolati virusa HIV-1 rezistentni na ritonavir nađeni su in vitro, i izdvojeni od bolesnika liječenih terapijskim dozama ritonavira.
English: As ritonavir is recommended to be taken with food and didanosine should be taken on an empty stomach, dosing should be separated by 2.5 h. Dose alterations should not be necessary.
Croatian: Budući da se preporučuje uzimanje ritonavira s hranom, a didanozin se mora uzimati na prazan želudac, između uzimanja dvaju lijekova treba načiniti razmak od 2,5 sata.
English: The maximum daily dose of this product is equivalent to 53% of the WHO recommended maximum daily intake for sodium.
Croatian: Maksimalna dnevna doza ovog lijeka iznosi 53% maksimalnog dnevnog unosa natrija prema preporukama SZO-a.
English: Patients with advanced HIV disease may be at risk of elevated triglycerides and pancreatitis (see section 4.4).
Croatian: Bolesnici s uznapredovalom HIV bolesti mogu biti izloženi većem riziku od povišenja razine triglicerida i pankreatitisa (vidjeti dio 4.4).
English: Paediatric population (2 years of age and above) The recommended dosage of ritonavir in children is 350 mg/m2 by mouth twice daily and should not exceed 600 mg twice daily.
Croatian: Pedijatrijska populacija (u dobi od 2 godine i stariji) Preporučena doza ritonavira u djece je 350 mg/m² dva puta na dan kroz usta, a doza ne smije premašiti 600 mg dva puta na dan.
English: Ritonavir is likely to change the uterine bleeding profile and reduce the effectiveness of estradiol-containing contraceptives (see section 4.4).
Croatian: Ritonavir vjerojatno mijenja profil uterinog krvarenja i smanjuje učinkovitost kontraceptiva koji sadržavaju estradiol (vidjeti dio 4.4).
English: Endothelin antagonists Bosentan
Croatian: Antagonisti endotelinskih receptora Bosentan
English: In patients who are already taking digoxin when ritonavir is introduced, the digoxin dose should be reduced to one-half of the patients' normal dose and patients need to be followed more closely than usual for several weeks after initiating co-administration of ritonavir and digoxin.
Croatian: Kada se ritonavir uvodi bolesnicima koji već uzimaju digoksin, dozu digoksina treba smanjiti na polovinu uobičajene, a bolesnike treba pratiti pažljivije nego inače nekoliko tjedana nakon početka istodobne primjene ritonavira i digoksina.
English: Steroids (e.g. dexamethasone, fluticasone propionate, prednisolone, triamcinolone) as ritonavir may raise the blood levels of these medicines which may lead to Cushing's syndrome (development of a rounded face) and reduce production of the hormone cortisol.
Croatian: - Steroidi (npr. deksametazon, flutikazonpropionat, prednizolon, triamcinolon), jer ritonavir može povisiti razine tih lijekova u krvi, što može izazvati pojavu Cushingova sindroma (stvaranje okruglog lica) i smanjiti stvaranje hormona kortizola.
English: Ultrastructural evidence suggests that these retinal changes may be secondary to phospholipidosis.
Croatian: Ultrastrukturna analiza upućuje na to da bi promjene na mrežnici mogle biti posljedica fosfolipidoze.
English: Caution must also be exercised and reduced doses should be considered if ritonavir is used concurrently with atorvastatin, which is metabolised to a lesser extent by CYP3A.
Croatian: Nužan je oprez, te treba razmotriti i smanjivanje doze ako se ritonavir daje istodobno s atorvastatinom, koji se u manjoj mjeri metabolizira putem CYP3A.
English: Ritonavir has a high affinity for several cytochrome P450 (CYP) isoforms and may inhibit oxidation with the following ranked order: CYP3A4 > CYP2D6.
Croatian: Ritonavir ima visok afinitet za nekoliko izoformi citokroma P450 (CYP) i može inhibirati oksidaciju ovim slijedom prema jačini: CYP3A4 > CYP2D6.
English: The protein binding of ritonavir in human plasma is approximately 98 - 99% and is constant over the concentration range of 1.0 - 100 μg/ml.
Croatian: Oko 98 - 99% ritonavira u ljudskoj plazmi veže se na proteine i to je vezanje nepromijenjeno u rasponu koncentracija od 1,0 do 100 µg /ml.
English: Co-administration of bosentan and ritonavir may increase steady state bosentan maximum concentrations (Cmax) and area under the curve (AUC).
Croatian: Istodobna primjena bosentana i ritonavira može povećati maksimalne koncentracije bosentana u stanju dinamičke ravnoteže (Cmax) i površinu ispod krivulje (AUC)
English: Cardiac and neurologic events have been reported when ritonavir has been co-administered with disopyramide, mexiletine or nefazodone.
Croatian: Prijavljeni su srčani i neurološki događaji kada se ritonavir davao istodobno s dizopiramidom, meksiletinom ili nefazodonom.
English: Recommended doses of Ritonavir Mylan are:
Croatian: Preporučene doze lijeka Ritonavir Mylan:
English: Pack sizes: 30, 90, 100 and multipack containing 90 (3 bottles of 30) film-coated tablets.
Croatian: Veličine pakiranja: 30, 90, 100 i multipakiranje od 90 (3 bočice po 30) filmom obloženih tableta.
English: Inhibition of HIV protease renders the enzyme incapable of processing the gag-pol polyprotein precursor which leads to the production of HIV particles with immature morphology that are unable to initiate new rounds of infection.
Croatian: Inhibicijom HIV-proteaze, taj enzim više ne može razgrađivati prekursor poliproteina gag-pol, zbog čega se stvaraju HIV-čestice nezrele morfologije, koje nisu sposobne pokretati nove cikluse infekcije.
English: Effects of food on oral absorption
Croatian: Učinak hrane na apsorpciju nakon oralne primjene
English: Contraindicated when used for the treatment of pulmonary arterial hypertension (PAH) only.
Croatian: Kontraindiciran samo kada se koristi u bolesnika s plućnom arterijskom hipertenzijom (PAH).
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jiroveci pneumonia.
Croatian: Mjerodavni primjeri su citomegalovirusni retinitis, generalizirane i/ili fokalne mikobakterijske infekcije i pneumonija koju uzrokuje
English: Ritonavir is principally metabolised and eliminated by the liver.
Croatian: Ritonavir se primarno metabolizira u jetri te putem nje i uklanja.
English: Ritonavir was not found to be mutagenic or clastogenic in a battery of in vitro and in vivo assays including the Ames bacterial reverse mutation assay using S. typhimurium and E. coli, the mouse lymphoma assay, the mouse micronucleus test and chromosomal aberration assays in human lymphocytes.
Croatian: Ritonavir se nije pokazao mutagenim ni klastogenim kompletom testova in vitro i in vivo, uključujući Amesov bakterijski test povratnih mutacija sa S. typhimurium i E. coli, test mišjeg limfoma, test mišjih mikronukleusa i testove kromosomskih aberacija ljudskih limfocita.
English: 117 Allée des Parcs, 69800 Saint-Priest, France
Croatian: 117 Allée des Parcs, 69800 Saint-Priest, Francuska
English: You must not take ritonavir with colchicine if you have kidney and/or liver problems (see also ‘Do not take Ritonavir Mylan' above).
Croatian: Ne smijete uzimati ritonavir s kolhicinom ako imate tegobe s bubrezima i/ili jetrom (pogledajte i dio „Nemojte uzimati Ritonavir Mylan” gore).
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and can occur many months after initiation of treatment (see section 4.4).
Croatian: Autoimuni poremećaji (kao što je Gravesova bolest i autoimuni hepatitis) su također zabilježeni; no zabilježeno je varijabilno vrijeme nastupa poremećaja koje može nastupiti i više mjeseci nakon započinjanja liječenja (vidjeti dio 4.4).
English: Increased glucose, increased magnesium, increased alkaline phosphatase
Croatian: Manje često Povišena vrijednost glukoze, povišena vrijednost magnezija, povišena vrijednost alkalne fosfataze
English: Hormonal contraceptive Ethinylestradiol
Croatian: Hormonski kontraceptivi Etinilestradiol
English: Systemic corticosteroid effects including Cushing's syndrome and adrenal suppression (plasma cortisol levels were noted to be decreased 86% in the above study) have been reported in patients receiving ritonavir and inhaled or intranasal fluticasone propionate; similar effects could also occur with other corticosteroids metabolised by CYP3A e.g., budesonide and triamcinolone.
Croatian: Sistemni učinci kortikosteroida uključuju Cushingov sindrom i supresiju nadbubrežnih žlijezda (u gornjem se ispitivanju pokazalo da su se razine kortizola u plazmi snizile za 86%) prijavljeni su u bolesnika koji su primali ritonavir i inhalacijski ili intranazalni flutikazonpropionat; sličnih bi učinaka moglo biti i pri primjeni drugih kortikosteroida koji se metaboliziraju putem CYP3A, npr. pri primjeni budezonida i triamcinolona.
English: In contrast to long-term administration of ritonavir, there was no significant interaction with bupropion after short-term administration of low doses of ritonavir (200 mg twice daily for 2 days), suggesting reductions in bupropion concentrations may have onset several days after initiation of ritonavir co-administration.
Croatian: Za razliku od dugotrajne primjene ritonavira, nije bilo značajne interakcije s bupropionom pri kratkotrajnoj primjeni ritonavira u malim dozama (200 mg dva puta na dan tijekom 2 dana), što upućuje na to da su se koncentracije bupropiona počinju smanjivati nekoliko dana nakon uvođenja ritonavira.
English: Effect on Coadministered Medicinal Products AUC
Croatian: Utjecaj istodobno primijenjenog lijeka na AUC
English: The use of higher ritonavir doses might alter the safety profile of the combination and therefore is not recommended.
Croatian: Primjena ritonavira u većim dozama može promijeniti profil neškodljivosti te kombinacije i stoga se ne preporučuje.
English: Other medicines and Ritonavir Mylan
Croatian: Drugi lijekovi i Ritonavir Mylan
English: After multiple dosing of ritonavir to healthy volunteers (500 mg twice daily) and subjects with mild to moderate hepatic impairment (Child Pugh Class A and B, 400 mg twice daily) exposure to ritonavir after dose normalisation was not significantly different between the two groups.
Croatian: Nakon višekratnog doziranja ritonavira zdravim dobrovoljcima (500 mg dva puta na dan) i ispitanicima s blago do umjereno oslabljenom funkcijom jetre (Child Pugh stupanj A i B, 400 mg dva puta na dan), izloženost dviju skupina ritonaviru nije se, nakon normalizacije doze, statistički značajno razlikovala.
English: Tell your doctor if you feel sick (nauseous), are vomiting, or have stomach pain, because these may be signs of an inflamed pancreas.
Croatian: Recite svome liječniku ako imate mučninu ili povraćate, ili ako imate bolove u želucu, jer to mogu biti znakovi upale gušterače.
English: Extra vigilance is warranted in patients with chronic hepatitis B or hepatitis C co-infection, as these patients have an increased risk of hepatotoxicity.
Croatian: Poseban je nadzor nužan u bolesnika s istodobnim infekcijama hepatitisom B ili C jer je u njih povećan rizik od hepatotoksičnosti.
English: Ritonavir also has a high affinity for P-glycoprotein and may inhibit this transporter.
Croatian: Ritonavir ima i visok afinitet za P-glikoprotein i može ga inhibirati.
English: The effect of ritonavir on rifampicin is not known.
Croatian: Ne zna se utječe li ritonavir na rifampicin.
English: If a patient is already taking St John's wort, St John's wort should be stopped and if possible check viral levels.
Croatian: Ako bolesnik već uzima gospinu travu, njenu primjenu trebalo bi obustaviti i, ako je moguće, provjeriti broj kopija virusa.
English: The increased digoxin levels may lessen over time (see section 4.5).
Croatian: Povišene razine digoksina mogu se s vremenom sniziti (vidjeti dio 4.5).
English: Haemophilia, as there have been reports of increased bleeding in patients with haemophilia who are taking this type of medicine (protease inhibitors).
Croatian: - Hemofiliju, jer je bilo prijava pojačanog krvarenja u bolesnika s hemofilijom koji uzimaju ovu vrstu lijekova (inhibitore proteaza).
English: Co-administration with ritonavir may cause a large increase in the concentration of this benzodiazepine.
Croatian: Pri njegovoj primjeni istodobno s ritonavirom moguć je velik porast koncentracije tog benzodiazepina.
English: 25-O-desacetyl rifabutin metabolite
Croatian: 25-O-dezacetil metabolit rifabutina
English: The following warnings apply when Ritonavir Mylan is taken as a full dose.
Croatian: Niže navedena upozorenja vrijede kada se Ritonavir Mylan uzima u punoj dozi.
English: Across dose groups, ritonavir oral clearance (CL/F/m2) declined with age with median values of 9.0 L/h/m2 in children less than 3 months of age, 7.8 L/h/m2 in children between 3 and 6 months of age and 4.4 L/h/m2 in children between 6 and 24 months of age.
Croatian: Usporedba skupina prema primljenim dozama pokazala je da se klirens oralno primijenjenog ritonavira (CL/F/m²) smanjivao s dobi, te su medijani vrijednosti iznosili 9,0 l/h/m² u djece mlađe od 3 mjeseca, 7,8 l/h/m² u djece u dobi od 3 do 6 mjeseci, a 4,4 l/h/m² u djece u dobi od 6 do 24 mjeseca.
English: Amphetamine derivatives Amphetamine
Croatian: Derivati amfetamina Amfetamin
English: Steroids
Croatian: Steroidi
English: Increased plasma concentrations of ergot derivatives leading to acute ergot toxicity, including vasospasm and ischaemia.
Croatian: Povećane koncentracije derivata ergota u plazmi, što dovodi do akutne ergotne toksičnosti, uključujući spazam krvnih žila i ishemiju.
English: For selected medicinal products (e.g. alprazolam) the inhibitory effects of ritonavir on CYP3A4 may decrease over time.
Croatian: Pri istodobnoj primjeni s nekim lijekovima (npr. alprazolamom), inhibicijski učinak ritonavira na CYP3A4 može s vremenom oslabiti.
English: Renal failure, renal impairment, elevated creatinine, hypophosphataemia and proximal tubulopathy (including Fanconi syndrome) have been reported with the use of tenofovir disoproxil fumarate (DF) in clinical practice (see section 4.8).
Croatian: Zatajenje bubrega, oštećenje funkcije bubrega, povišene razine kreatinina, hipofosfatemija i proksimalna tubulopatija (uključujući Fanconijev sindrom) zabilježeni su u kliničkoj praksi prilikom primjene tenofovirdizoproksilfumarata (DF) (vidjeti dio 4.8).
English: Pancreatitis has been observed in patients receiving ritonavir therapy, including those who developed hypertriglyceridemia.
Croatian: U bolesnika koji su primali ritonavir uočena je pojava pankreatitisa, uključujući bolesnike koji su razvili hipertrigliceridemiju.
English: Hepatitis B or C and are being treated with a combination of antiretroviral agents, as you are at a greater risk of a severe and potentially life threatening reaction because of the effect on the liver.
Croatian: - Hepatitis B ili C i liječite se kombinacijom antiretrovirusnih lijekova, jer ste izloženi većem riziku od teške i možda za život opasne reakcije zbog učinka na jetru.
English: Herbal preparations containing St John's wort must not be used in combination with ritonavir.
Croatian: Biljni pripravci koji sadržavaju gospinu travu ne smiju se koristiti u kombinaciji s ritonavirom.
English: Low doses of ritonavir have shown profound effects on the pharmacokinetics of other protease inhibitors (and other products metabolised by CYP3A4) and other protease inhibitors may influence the pharmacokinetics of ritonavir (see section 4.5).
Croatian: Pokazalo se da ritonavir u malim dozama snažno utječe na farmakokinetiku drugih inhibitora proteaza (i ostalih pripravaka koji se metaboliziraju putem CYP3A4), te da drugi inhibitori proteaza mogu utjecati na farmakokinetiku ritonavira (vidjeti dio 4.5).
English: Phenytoin may decrease serum levels of ritonavir.
Croatian: Fenitoin može sniziti razine ritonavira u serumu.
English: The inhibitory effect of ritonavir (with or without other protease inhibitors) on P-gp activity may decrease over time (e.g. digoxin and fexofenadine-see table “Ritonavir effects on non-antiretroviral medicinal products” below).
Croatian: Inhibicijski učinak ritonavira (sa ili bez drugih inhibitora proteaza) na P-gp može s vremenom oslabiti (npr. u slučaju digoksina i feksofenadina - vidjeti tablicu „Učinci ritonavira na lijekove koji nisu antiretrovirotici” u nastavku teksta).
English: 100q12h↑ 57% ↑ 77%
Croatian: 100 svakih 12 h ↑ 57% ↑ 77%
English: This increase is likely due to ritonavir and a more pronounced effect may be observed during prolonged co-administration.
Croatian: Ovo povišenje se vjerojatno događa zbog ritonavira i moguć je izraženiji učinak tijekom produljene primjene.
English: If a side effect is preventing you from taking Ritonavir Mylan as directed, tell your doctor straight away.
Croatian: Bude li Vas koja nuspojava sprječavala da uzimate Ritonavir Mylan prema uputi, odmah to recite svom liječniku.