FrancophonIA/ELRC3.0 huggingface dataset:
English: The dose of nelfinavir was 750 mg given three times a day.
Slovenian: Odmerek nelfinavirja je bil 750 mg trikrat na dan.
English: While the clinical significance of decreased indinavir concentrations has not been established, the magnitude of the observed pharmacokinetic interaction should be taken into consideration when choosing a regimen containing both efavirenz and indinavir.
Slovenian: Kliničnega pomena zmanjšanih koncentracij indinavirja niso ugotovili, vendar je treba stopnjo opažene farmakokinetične interakcije upoštevati pri izbiri režima zdravljenja, pri katerem se uporabljata oba - efavirenz in indinavir.
English: There were insufficient data to determine whether moderate or severe hepatic impairment (Child-Pugh Class B or C) affects efavirenz pharmacokinetics.
Slovenian: Podatkov za določitev, ali zmerna ali huda okvara jeter (razred B ali C po Child Pugh-u) vpliva na farmakokinetiko efavirenza, ni bilo dovolj.
English: Patients who are receiving concomitant anticonvulsant medicinal products primarily metabolised by the liver, such as phenytoin, carbamazepine and phenobarbital, may require periodic monitoring of plasma levels.
Slovenian: Pri bolnikih, ki sočasno prejemajo antikonvulzive, ki se primarno metabolizirajo v jetrih, kot so fenitoin, karbamazepin in fenobarbital, je lahko potrebno periodično spremljanje plazemskih koncentracij.
English: Although cross-resistance of efavirenz with PIs has not been documented, there are at present insufficient data on the efficacy of subsequent use of PI based combination therapy after failure of regimens containing SUSTIVA.
Slovenian: Čeprav navzkrižna rezistenca efavirenza z ZP ni dokumentirana, trenutno nimamo dovolj podatkov o učinkovitosti uporabe kombiniranega zdravljenja, ki vključuje ZP, po neuspelem zdravljenju z režimom, ki je vključeval tudi zdravilo SUSTIVA.
English: An alternative anticonvulsant should be considered.
Slovenian: Pretehtati je treba možnost uporabe drugega antikonvulziva.
English: In HIV-1 infected patients (n = 6), the pharmacokinetics of indinavir and efavirenz were generally comparable to these uninfected volunteer data.
Slovenian: Pri bolnikih, okuženih s HIV-1 (n = 6), sta bili farmakokinetiki indinavirja in efavirenza primerljivi s podatki za neokužene prostovoljce.
English: In a study of uninfected volunteers, a representative nervous system symptom had a median time to onset of 1 hour post-dose and a median duration of 3 hours.
Slovenian: V študiji pri neokuženih prostovoljcih, se je značilen simptom živčnega sistema pojavil 1 uro (mediana vrednost) po odmerku in je trajal 3 ure (mediana vrednost).
English: Efavirenz must not be used as a single agent to treat HIV or added on as a sole agent to a failing regimen.
Slovenian: Efavirenza se ne sme uporabljati kot samostojno zdravilo za zdravljenje HIV, prav tako se ga kot edinega ne sme dodati k neuspelemu režimu zdravljenja.
English: Laboratory tests should be performed to evaluate their liver disease at periodic intervals (see section 4.2).
Slovenian: Za oceno stopnje jetrne bolezni je treba periodično opravljati laboratorijske teste (glejte poglavje 4.2).
English: The single substitutions which led to the highest resistance to efavirenz in cell culture correspond to a leucine-to-isoleucine change at position 100 (L100I, 17 to 22-fold resistance) and a lysine-to-asparagine at position 103 (K103N, 18 to 33-fold resistance).
Slovenian: Enkratne substitucije, ki so povzročile največjo rezistenco na efavirenz v celični kulturi, so ustrezale spremembi levcina v izolevcin na mestu 100 (L100I, 17 do 22-krat večja rezistenca) in spremembi lizina v asparagin na mestu 103 (K103N, 18 do 33-krat večja rezistenca).
English: if you are currently taking any of the following medicines(see also “Other medicines and Sustiva”):
Slovenian: če trenutno jemljetekatero koli od naslednjih zdravil(glejte tudi "Druga zdravila in zdravilo Sustiva"):
English: A few of the postmarketing reports of hepatic failure, including cases in patients with no pre-existing hepatic disease or other identifiable risk factors, were characterized by a fulminant course, progressing in some cases to transplantation or death.
Slovenian: V nekaj postmarketinških poročilih o odpovedi jeter, vključno s primeri pri bolnikih brez predhodne bolezni jeter ali drugih odkritih dejavnikov tveganja, je bil opisan tudi fulminantni potek, ki je v nekaterih primerih napredoval do transplantacije ali smrti.
English: If you stop taking SUSTIVA
Slovenian: Če ste prenehali jemati zdravilo SUSTIVA
English: Study ACTG 364 enrolled 196 patients who had been treated with NRTIs but not with PIs or NNRTIs.
Slovenian: Študija ACTG 364 je vključevala 196 bolnikov, zdravljenih z NRTI, ne pa z ZP ali NNRTI.
English: If SUSTIVA is started because your current treatment has not prevented the virus from multiplying, another medicine you have not taken before must be started at the same time.
Slovenian: Če boste začeli z jemanjem zdravila SUSTIVA zato, ker dosedanji način zdravljenja ni preprečil razmnoževanja virusa, morate hkrati začeti jemati tudi drugo protivirusno zdravilo, ki ga do sedaj še niste jemali.
English: 8 Sprinkle the contents of the capsule on the food (illustration d).
Slovenian: 8 Posujte vsebino kapsule po hrani (slika d).
English: 4 Place 1-2 teaspoons of the food in a small container (illustration a).
Slovenian: 4 Dajte 1-2 čajni žlički hrane v majhno posodo (slika a).
English: When prescribing medicinal products concomitantly with efavirenz, physicians should refer to the corresponding Summary of Product Characteristics.
Slovenian: Pri predpisovanju zdravil, ki se jemljejo hkrati z efavirenzem, mora zdravnik upoštevati ustrezni Povzetek glavnih značilnosti zdravila.
English: Psychiatric disorders common abnormal dreams, anxiety, depression, insomnia*
Slovenian: Psihiatrične motnje pogosti nenormalne sanje, anksioznost, depresija, nespečnost*
English: Diltiazem or similar medicines (called calcium channel blockers which are medicines typically used for high blood pressure or heart problems): when you start taking SUSTIVA, your doctor may need to adjust your dose of the calcium channel blocker.
Slovenian: Diltiazem ali podobna zdravila (imenovana zaviralci kalcijevih kanalov in so zdravila, ki se običajno uporabljajo za zvišan krvni tlak ali težave s srcem): ko boste začeli jemati zdravilo SUSTIVA, vam bo zdravnik morda moral prilagoditi odmerek zaviralca kalcijevih kanalov.
English: There is insufficient information on the effects of efavirenz in newborns/infants.
Slovenian: O učinkih efavirenza na novorojenčke/dojenčke ni dovolj podatkov.
English: Your doctor will give you instructions for proper dosing.
Slovenian: Navodila za pravilno odmerjanje vam bo dal zdravnik.
English: Nervous system disorders common cerebellar coordination and balance disturbances†, disturbance in attention (3.6%), dizziness (8.5%), headache (5.7%), somnolence (2.0%)*
Slovenian: Bolezni živčevja pogosti motnje cerebelarne koordinacije in ravnotežja motnje koncentracije (3,6 %), omotica (8,5 %), glavobol (5,7 %), zaspanost (2,0 %)*
English: Use of efavirenz in combination with saquinavir as the sole protease inhibitor is not recommended.
Slovenian: Uporabe efavirenza v kombinaciji s sakvinavirjem, kot edinim zaviralcem proteaze, ne priporočamo.
English: Do not use this medicine after the expiry date which is stated on the bottle or blister and on the carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na plastenki in na škatli poleg oznake "Uporabno do" ali "EXP".
English: Dark yellow, capsule-shaped, printed with “SUSTIVA” on both sides.
Slovenian: Temno rumene barve, v obliki kapsule in imajo napis "SUSTIVA" na obeh straneh.
English: The clinical significance of these changes in clarithromycin plasma levels is not known.
Slovenian: Klinični pomen teh sprememb v koncentracijah klaritromicina v plazmi ni znan.
English: While effective viral suppression with antiretroviral therapy has been proven to substantially reduce the risk of sexual transmission, a residual risk cannot be excluded.
Slovenian: Čepav je bilo dokazano, da učinkovita supresija virusa s protivirusnim zdravljenjem znatno zmanjšuje tveganje za prenos s spolnimi odnosi, ne smemo izključiti rezidualnega tveganja.
English: This is very important because the amount of virus may start to increase if the medicine is stopped for even a short time.
Slovenian: To je zelo pomembno, kajti če prenehate jemati zdravilo, pa čeprav za kratek čas, lahko začne količina virusa naraščati in postane nadaljnje zdravljenje težje.
English: In HIV-1 infected patients (n = 9) who received efavirenz 200 to 600 mg once daily for at least one month, cerebrospinal fluid concentrations ranged from 0.26 to 1.19% (mean 0.69%) of the corresponding plasma concentration.
Slovenian: Pri bolnikih, okuženih s HIV-1 (n = 9), ki so vsaj en mesec dobivali 200 do 600 mg efavirenza enkrat na dan, je bila njegova koncentracija v cerebrospinalni tekočini v območju od 0,26 do 1,19 % (povprečno 0,69 %) ustrezne plazemske koncentracije.
English: In view of the data presented in the reviewed PSUR, the overall risk-benefit balance of efavirenz is therefore considered unchanged in the approved indications provided that the terms of the marketing authorisation are varied as relevant.
Slovenian: Ob upoštevanju podatkov, predstavljenih v pregledanem poročilu PSUR, ostaja skupno razmerje med tveganji in koristmi efavirenza za odobrene indikacije nespremenjeno, pod pogojem, da se spremenijo pogoji dovoljenja za promet z zdravilom, kot je ustrezno.
English: Steps 11-14 must be completed within 30 minutes of mixing: 11 Give the mixture of food and capsule contents to the child, making sure he or she eats the full amount (illustration f).
Slovenian: Korake 11-14 je treba dokončati v 30 minutah po pripravi mešanice: 11 Mešanico hrane in vsebine kapsule dajte otroku.
English: The clinical effect of this dose adjustment has not been adequately evaluated.
Slovenian: Kliničnega učinka take prilagoditve odmerka niso zadostno ovrednotili.
English: Efavirenz regimen (n=1,008)
Slovenian: bolniki, ki so prejemali efavirenz (n = 1.008)
English: See also ritonavir row above.
Slovenian: Glejte tudi informacije za ritonavir zgoraj.
English: There have been seven retrospective reports of findings consistent with neural tube defects, including meningomyelocele, all in mothers exposed to efavirenz-containing regimens (excluding any efavirenzcontaining fixed-dose combination tablets) in the first trimester.
Slovenian: Na voljo je sedem retrospektivnih poročil, ki kažejo na okvare nevralne cevi, vključno z meningomielokelo, vsa pri materah, ki so bile v prvem trimesečju nosečnosti izpostavljene režimu zdravljenja z efavirenzem (katere koli tablete s fiksno kombinacijo odmerkov efavirenza niso vključene).
English: If therapy with efavirenz is discontinued, consideration should also be given to interrupting therapy with other antiretroviral agents to avoid development of resistant virus (see section 4.8).
Slovenian: Če zdravljenje z efavirenzem prekinemo, je treba razmisliti tudi o prenehanju zdravljenja z drugimi protiretrovirusnimi zdravili, da se izognemo razvoju rezistentnega virusa (glejte poglavje 4.8).
English: Antiviral activity
Slovenian: Protivirusna aktivnost
English: Efavirenz induced foetal resorptions in rats.
Slovenian: Efavirenz je pri podganah povzročil resorpcijo plodu.
English: Because of the extensive cytochrome P450-mediated metabolism of efavirenz and limited clinical experience in patients with chronic liver disease, caution must be exercised in administering efavirenz to patients with mild hepatic impairment.
Slovenian: Zaradi obsežnega metabolizma efavirenza, vezanega na citokrom P450, in omejenih kliničnih izkušenj pri bolnikih s kronično boleznijo jeter je potrebna previdnost pri predpisovanju efavirenza bolnikom z blago okvaro jeter.
English: There is no specific antidote for overdose with efavirenz.
Slovenian: Specifičnega antidota za preveliko odmerjanje efavirenza ni.
English: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki se zdravijo s kombinacijo protiretrovirusnih zdravil, se lahko pojavi bolezen kosti, imenovana osteonekroza (odmiranje kostnega tkiva zaradi nezadostne prekrvavitve kosti).
English: The potential for cross-resistance between efavirenz and NRTIs is low because of the different binding sites on the target and mechanism of action.
Slovenian: Možnost za navzkrižno rezistenco med efavirenzem in NRTI-ji je majhna zaradi različnih vezavnih mest in različnega mehanizma delovanja.
English: *lower than recommended doses; similar findings are expected with recommended doses.
Slovenian: *nižji od priporočenih odmerkov, podobno pričakujemo pri priporočenih odmerkih darunavir:
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Slovenian: Zdravljenje mora uvesti zdravnik z izkušnjami pri zdravljenju okužbe s HIV.
English: Concomitant administration with efavirenz should be avoided due to the risk for QTc prolongation (see section 4.3).
Slovenian: Sočasni uporabi efavirenza se je treba izogibati zaradi tveganja za podaljšanje intervala QTc (glejte poglavje 4.3).
English: Patients should be monitored carefully for dose-related adverse reactions, especially nervous system symptoms.
Slovenian: Bolnike je treba pozorno spremljati zaradi od odmerka odvisnih neželenih učinkov, še posebej simptomov živčnega sistema.
English: Isolated elevations of GGT in patients receiving efavirenz may reflect enzyme induction.
Slovenian: Posamezna povišanja GGT pri bolnikih, ki prejemajo efavirenz, lahko kažejo indukcijo encimov.
English: Efavirenz film-coated tablets are not suitable for children weighing less than 40 kg.
Slovenian: Efavirenz filmsko obložene tablete niso primerne za otroke, ki tehtajo manj kot 40 kg.
English: Reported rates of recurrent rash following a switch from nevirapine to efavirenz therapy, primarily based on retrospective cohort data from published literature, range from 13 to 18%, comparable to the rate observed in patients treated with efavirenz in clinical studies.
Slovenian: Delež ponovitev izpuščaja po zamenjavi zdravljenja z nevirapinom z zdravljenjem z efavirenzem, o katerem so poročali in ki temelji na podatkih iz retrospektivnih kohortnih študij iz objavljene literature, znaša od 13 do 18 %, kar je primerljivo z deležem, ki so ga opazili pri bolnikih, ki so se z efavirenzem zdravili v kliničnih študijah.
English: SUSTIVA taken in combination with other antiretroviral medicines reduces the amount of the virus in the blood.
Slovenian: Zdravilo SUSTIVA v kombinaciji z drugimi protiretrovirusnimi zdravili zmanjšuje količino virusa v krvi.
English: As a result, the amounts of SUSTIVA or other medicines in your blood may be affected.
Slovenian: Posledično se lahko spremeni količina zdravila SUSTIVA ali drugih zdravil v krvi.
English: The steady-state AUC, Cmax and Cmin of the active carbamazepine epoxide metabolite remained unchanged.
Slovenian: AUC, Cmax in Cmin aktivnega presnovka karbamazepinijevega epoksida v stanju dinamičnega ravnovesja so ostale nespremenjene.
English: In uninfected volunteers, multiple doses of 200 - 400 mg per day for 10 days resulted in a lower than predicted extent of accumulation (22 - 42% lower) and a shorter terminal half-life compared with single dose administration (see below).
Slovenian: Pri neokuženih prostovoljcih so 10dnevni večkratni odmerki 200 - 400 mg na dan povzročili manjšo akumulacijo zdravila od pričakovane (22 - 42 % manjšo) in krajši končni razpolovni čas v primerjavi z enkratnim odmerkom (glejte spodaj).
English: The pattern of amino acid substitutions in RT associated with resistance to efavirenz was independent of the other antiviral medicines used in combination with efavirenz.
Slovenian: Struktura aminokislinskih substitucij na RT, ki so bile povezane z rezistenco na efavirenz, ni bila odvisna od uporabe drugih protivirusnih zdravil v kombinaciji z efavirenzem.
English: Efavirenz has a relatively long terminal half-life of at least 52 hours after single doses and 4055 hours after multiple doses.
Slovenian: Efavirenz ima relativno dolg končni razpolovni čas: vsaj 52 ur po enkratnem odmerku in 40 do 55 ur po večkratnih odmerkih.
English: d S.E.M., standard error of the mean.
Slovenian: S.N.P., standardna napaka povprečja.
English: Medicines used to treat malaria: artemether/lumefantrine: SUSTIVA may reduce the amount of artemether/lumefantrine in your blood.
Slovenian: Zdravila za zdravljenje malarije: artemeter/lumefantrin: zdravilo SUSTIVA lahko zmanjša količino artemetra/lumefantrina v krvi.
English: Patients with a history of psychiatric disorders appear to be at greater risk of these serious psychiatric adverse reactions with frequencies ranging from 0.3% for manic reactions to 2.0% for both severe depression and suicidal ideation.
Slovenian: Kaže, da obstaja pri bolnikih, ki so v preteklosti že imeli psihiatrične motnje, večje tveganje za te resne psihiatrične neželene učinke, pri čemer pogostnost vsakega od zgoraj navedenih neželenih učinkov znaša od 0,3 % za manične reakcije do 2,0 % za hudo obliko depresije in za misli na samomor.
English: Patients and caregivers must be instructed to open the capsule carefully to avoid spillage or dispersion of the capsule contents into the air.
Slovenian: Bolniki in negovalci naj previdno odpirajo kapsule, da ne pride do raztresenja vsebine ali razpršitve vsebine kapsule po zraku.
English: 42 x 1 hard capsules: blister
Slovenian: 42 x 1 trdih kapsul: pretisni omot
English: Greater than 100-fold loss of susceptibility was observed against HIV variants expressing K103N in addition to other amino acid substitutions in RT.
Slovenian: Več kot 100-kratno izgubo dovzetnosti so opazili proti HIV različicam, ki so imele poleg drugih aminokislinskih substitucij na RT tudi substitucijo K103N.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV in/ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART).
English: No dose adjustment is necessary for rifampicin, including 600 mg.
Slovenian: Prilagoditev odmerka rifampicina, vključno s 600 mg ni potrebna.
English: The safety and efficacy of efavirenz in children below the age of 3 months or weighing less than 3.5 kg have not been established.
Slovenian: Varnost in učinkovitost efavirenza pri otrocih, mlajših od 3 mesecev ali lažjih od 3,5 kg, še nista bili dokazani.
English: Nervous system symptoms of moderate-to-severe intensity were experienced by 19% (severe 2%) of patients compared to 9% (severe 1%) of patients receiving control regimens.
Slovenian: Zmerni do hudi simptomi živčnega sistema so se pojavili pri 19 % bolnikov (hudi pri 2,0 %), v primerjavi z 9 % bolnikov (hudi pri 1 %) na kontrolnem režimu.
English: Studies in humans and in vitro studies using human liver microsomes have demonstrated that efavirenz is principally metabolised by the cytochrome P450 system to hydroxylated metabolites with subsequent glucuronidation of these hydroxylated metabolites.
Slovenian: Študije na ljudeh in in vitro študije z uporabo človeških jetrnih mikrosomov so pokazale, da se efavirenz metabolizira predvsem s sistemom citokroma P450, in sicer v hidroksilirane metabolite, ki se potem vežejo na glukuronsko kislino.
English: Hormonal contraceptive, such as birth control pills, an injected contraceptive (for example, Depo-Provera), or a contraceptive implant (for example, Implanon): you must also use a reliable barrier method of contraception (see Pregnancy,breast-feeding and fertility).
Slovenian: Hormonske kontraceptive, kot so kontracepcijske tablete, kontraceptivi v obliki injekcij (na primer Depo-Provera) ali kontracepcijski vsadki (na primer Implanon): uporabljati morate tudi zanesljivo mehansko obliko kontracepcije (glejte Nosečnost, dojenje in plodnost).
English: Nervous system symptoms may occur more frequently when efavirenz is taken concomitantly with meals possibly due to increased efavirenz plasma levels (see section 5.2).
Slovenian: Simptomi živčnega sistema se lahko pojavijo pogosteje, kadar se efavirenz jemlje skupaj s hrano, verjetno zaradi povečanih vrednosti efavirenza v plazmi (glejte poglavje 5.2).
English: In clinical studies 2% of patients treated with efavirenz discontinued therapy due to such symptoms.
Slovenian: V kliničnih študijah je 2 % bolnikov, zdravljenih z efavirenzem, zaradi takih simptomov prekinilo zdravljenje.
English: Phenytoin, Phenobarbital, and other anticonvulsants that are substrates of CYP450 isoenzymes
Slovenian: fenitoin, fenobarbital in drugi antikonvulzivi, ki so substrati izoencimov CYP450
English: SUSTIVA must always be taken in combination with other anti-HIV medicines.
Slovenian: Vedno ga jemljite le v kombinaciji z drugimi zdravili proti HIV.
English: If you are taking any of these medicines, tell your doctor immediately.
Slovenian: Če jemljete katero koli od naštetih zdravil, to takoj povejte zdravniku.
English: Patients with mild liver disease may be treated with their normally recommended dose of efavirenz.
Slovenian: Bolnike z blago boleznijo jeter se lahko zdravi z običajnim priporočenim odmerkom efavirenza.
English: Two additional cases (1 prospective and 1 retrospective) including events consistent with neural tube defects have been reported with the fixed-dose combination tablet containing efavirenz, emtricitabine, and tenofovir disoproxil fumarate.
Slovenian: O dveh dodatnih primerih (1 prospektiven in 1 retrospektiven), ki vključujeta dogodke, ki kažejo na okvare nevralne cevi, so poročali pri uporabi tablet s fiksno kombinacijo odmerkov efavirenza, emtricitabina in dizoproksiltenofovirat fumarata.
English: Although in vitro data suggest that efavirenz inhibits CYP2C9 and CYP2C19, there have been contradictory reports of both increased and decreased exposures to substrates of these enzymes when coadministered with efavirenz in vivo.
Slovenian: Čeprav in vitro podatki kažejo, da efavirenz zavira CYP2C9 in CYP2C19, obstajajo nasprotujoča si poročila tako o povečani kot tudi o zmanjšani izpostavitvi substratom za ta encima pri sočasni uporabi z efavirenzem in vivo.
English: Malformations were observed in 3 of 20 foetuses/ newborns from efavirenz-treated cynomolgus monkeys given doses resulting in plasma efavirenz concentrations similar to those seen in humans.
Slovenian: Malformacije so opazili pri 3 od 20 zarodkov/mladičev opic vrste Cynomolgus, ki so bile zdravljene z efavirenzem v odmerkih, s katerimi so dosegli plazemske koncentracije efavirenza, ki so podobne tistim pri človeku.
English: In most patients rash resolves with continuing therapy with efavirenz within one month.
Slovenian: Pri večini bolnikov izpuščaj izgine v enem mesecu nadaljnjega zdravljenja z efavirenzem.
English: Sufficient data on the tolerability of efavirenz with lowdose ritonavir (100 mg, once or twice daily) are not available.
Slovenian: Zadostnih podatkov o prenašanju efavirenza z majhnimi odmerki ritonavirja (100 mg, enkrat ali dvakrat na dan) ni na voljo.
English: The in vitro studies suggest that CYP3A4 and CYP2B6 are the major isozymes responsible for efavirenz metabolism and that it inhibited P450 isozymes 2C9, 2C19, and 3A4.
Slovenian: Študije in vitro kažejo, da sta CYP3A4 in CYP2B6 glavna izoencima, odgovorna za metabolizem efavirenza, in da efavirenz inhibira P450 izoencime 2C9, 2C19 in 3A4.