FrancophonIA/ELRC3.0 huggingface dataset:
English: The other ingredients in the tablet core are (see section 2 ‘Clopidogrel Teva Pharma B.V. contains lactose' and ‘Clopidogrel Teva Pharma B.V. contains hydrogenated castor oil') lactose monohydrate, microcrystalline cellulose, hydroxypropylcellulose (E463), crospovidone (type A), hydrogenated castor oil and sodium laurilsulfate, and in the film-coating are lactose monohydrate, hypromellose (E464), titanium dioxide (E171), macrogol 4000, iron oxide red (E172), iron oxide yellow (E172), indigo carmine aluminium lake (E132).
Bulgarian: Pomožne snovi v jedru tablete so (glejte poglavje 2 »Zdravilo Klopidogrel Teva Pharma B.V. vsebuje laktozo« in »Zdravilo Klopidogrel Teva Pharma B.V. vsebuje hidrogenirano ricinusovo olje«: laktoza monohidrat, mikrokristalna celuloza, hidroksipropil celuloza (E463), krospovidon (tip A), hidrogenirano ricinusovo olje in natrijev lavrilsulfat.
English: Patients received clopidogrel (75 mg/day, n=22,961) or placebo (n=22,891), in combination with ASA (162 mg/day), for 28 days or until hospital discharge.
Bulgarian: Bolniki so 28 dni oziroma do odpusta dobivali klopidogrel (75 mg na dan, n=22.961) ali placebo (n=22.891) v kombinaciji z acetilsalicilnsko kislino (162 mg na dan).
English: The influence of CYP2C19 genotype on clinical outcomes in patients treated with clopidogrel has not been evaluated in prospective, randomised, controlled trials.
Bulgarian: Vpliv CYP2C19-genotipa na klinične izide pri bolnikih, zdravljenih
English: - Keep this leaflet.
Bulgarian: Previdno odlepite zadnjo stran.
English: Medicinal products that inhibit CYP2C19 include omeprazole and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, ciprofloxacin, cimetidine, carbamazepine, oxcarbazepine and chloramphenicol.
Bulgarian: in esomeprazol, fluvoksamin, fluoksetin, moklobemid, vorikonazol, flukonazol, tiklopidin, ciprofloksacin, cimetidin, karbamazepin, okskarbazepin in kloramfenikol.
English: Symptoms may include altered behaviour, headaches, coma, visual disturbances, seizures (fitting), kidney failure, fever, extreme tiredness, weakness, or bleeding into the stomach, bowels or skin (including small red spots or large bruised areas)
Bulgarian: Simptomi lahko vključujejo spremembe vedenja, glavobole, komo, motnje vida, napade (krče), odpovedovanje ledvic, povišano telesno temperaturo, hudo utrujenost, šibkost ali krvavitve iz želodca, črevesja ali kože (vključno z manjšimi rdečimi madeži ali večjimi odrgninami).
English: Aluminium-aluminium peelable perforated unit-dose blisters, aluminium-aluminium perforated unit dose blisters and HDPE bottles with polypropylene closures or child resistant polypropylene closures and silica gel desiccant.
Bulgarian: Perforirani pretisni omoti iz aluminija za enkratno odmerjanje, ki se odlepijo in perforirani pretisni omoti za enkratno odmerjanje iz aluminija ter HDPE stekleničke z zaporkami iz polipropilena ter silikagel sušilno sredstvo.
English: Bleeding is the most common reaction reported both in clinical studies as well as in post-marketing experience where it was mostly reported during the first month of treatment.
Bulgarian: Krvavitve so bile najpogosteje opisan učinek tako v kliničnih študijah kot v obdobju
English: As with other antiplatelet agents, clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions and in patients receiving treatment with ASA, heparin, glycoprotein IIb/IIIa inhibitors or non-steroidal anti-inflammatory drugs (NSAIDs) including Cox-2 inhibitors, or selective serotonin reuptake inhibitors (SSRIs).
Bulgarian: s tveganjem za povečano krvavitev zaradi poškodbe, kirurškega posega ali drugih patoloških stanj in pri bolnikih, ki se zdravijo z acetilsalicilno kislino, heparinom ali zaviralci glikoproteina IIb/IIIa ali nesteroidnimi protivnetnimi zdravili (NSAID) vključno z zaviralci COX-2 ali
English: Light pink to pink, capsule-shaped film-coated tablets debossed with “C75” on one side and plain on the other side.
Bulgarian: tablete v obliki kapsul, ki imajo na eni strani gladko površino, na drugi strani pa vtisnjeno oznako »C75«.
English: Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.
Bulgarian: Zavrta je tudi agregacija trombocitov, ki jo izzovejo drugi agonisti kot ADP, ker pride do blokade ojačenja trombocitne aktivacije
English: INFORMATION IN BRAILLE Clopidogrel Teva Pharma B.V. 75 mg
Bulgarian: PODATKI V BRAILLOVI PISAVI Klopidogrel Teva Pharma B.V. 75 mg
English: At very high doses, a poor gastric tolerability (gastritis, gastric erosions and/or vomiting) of clopidogrel was also reported in rat and baboon.
Bulgarian: Pri podganah in pavijanih so poročali tudi o slabem želodčnem prenašanju (gastritis, želodčne erozije in/ali bruhanje), pri uporabi zelo velikih odmerkov.
English: Lactose monohydrate Hypromellose (E464) Titanium dioxide (E171) Macrogol 4000
Bulgarian: Filmska obloga laktoza monohidrat hipromeloza (E464) titanov dioksid (E171) makrogol 4000 rdeči železov oksid (E172) rumeni železov oksid (E172) indigotin (E132)
English: Prolonged bleeding, bleeding inside the head, bleeding in the eye, blood in the urine and/or purpura (red spots on the skin caused by bleeding underneath the skin) Rashes, itching, abnormal touch sensation
Bulgarian: podaljšan čas krvavitve, krvavitve v dihalih, krvavitve v očesu, kri v urinu in/ali purpura (rdeče pike na koži, ki nastajajo zaradi krvavitev pod kožo),
English: Prevention of atherothrombotic and thromboembolic events in atrial fibrillation In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists (VKA) and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke.
Bulgarian: tveganja za žilne dogodke in ki niso primerni za zdravljenje z antagonisti vitamina K (VKA) ter imajo majhno tveganje za krvavitev, je klopidogrel v kombinaciji z ASA indiciran za preprečevanje aterotrombotičnih in trombemboličnih dogodkov, vključno z možgansko kapjo.
English: In cases of confirmed isolated activated Partial Thromboplastin Time (aPTT) prolongation with or without bleeding, acquired haemophilia should be considered.
Bulgarian: V primeru potrjenega izoliranega podaljšanja aktiviranega parcialnega tromboplastičnega časa (aPTČ)
English: However, patients entered into clinical trials with clopidogrel received a variety of concomitant medicinal products including diuretics, beta blockers, ACEI, calcium antagonists, cholesterol lowering agents, coronary vasodilators, antidiabetic agents (including insulin), antiepileptic agents, and GPIIb/IIIa antagonists without evidence of clinically significant adverse interactions.
Bulgarian: Vendar pa so bolniki, ki so bili vključeni v klinična preskušanja klopidogrela, sočasno prejemali različna zdravila, vključno z diuretiki, blokatorji beta, zaviralci angiotenzinske konvertaze, kalcijevimi antagonisti, sredstvi za zmanjševanje ravni holesterola, koronarnimi vazodilatatorji, antidiabetiki
English: Your doctor should have prescribed Clopidogrel Teva Pharma B.V. plus acetylsalicylic acid if you cannot take ‘oral anticoagulants' and you do not have a risk of major bleeding.
Bulgarian: skupaj z acetilsalicilno kislino, če ne morete prejemati "peroralnih antikoagulantov", ali če nimate tveganja za večjo krvavitev.
English: No substantial differences in active metabolite exposure and mean inhibition of platelet aggregation (IPA) were observed between ultrarapid, extensive and intermediate metabolisers.
Bulgarian: Med ultrahitrimi, dobrimi in srednjimi metabolizatorji niso ugotovili bistvenih razlik v izpostavljenosti aktivnemu presnovku in povprečnem zavrtju agregacije trombocitov (IPA).
English: • Bruising, haematoma (unusual bleeding under the skin), nose bleeds, bleeding in the stomach or bowels, increased bleeding at the site of a puncture wound
Bulgarian: odrgnine, hematomi (neobičajne krvavitve pod kožo), krvavitve iz nosu, krvavitve iz želodca ali črevesja, povečane krvavitve na mestu vboda,
English: The CYP2C19*1 allele corresponds to fully functional metabolism while the CYP2C19*2 and CYP2C19*3 alleles are nonfunctional.
Bulgarian: ustreza polno funkcionalni presnovi, medtem ko alela CYP2C19*2
English: Bleeding was the most frequently reported adverse reaction in both clopidogrel and placebo groups; however, there was no significant difference in the bleeding rate between groups.
Bulgarian: s placebom je bila krvavitev, vendar se pojavljanje krvavitev med skupinama ni značilno razlikovalo.
English: If you forget to take Clopidogrel Teva Pharma B.V.
Bulgarian: Če ste pozabili vzeti zdravilo Klopidogrel Teva Pharma B.V.
English: Patients received clopidogrel (300 mg loading dose, followed by 75 mg/day, n=1,752) or placebo (n=1,739), both in combination with ASA (150 to 325 mg as a loading dose, followed by 75 to 162 mg/day), a fibrinolytic agent and, when appropriate, heparin.
Bulgarian: Bolniki so dobivali klopidogrel (300 mg udarni odmerek, nato pa 75 mg na dan, n=1.752) ali placebo (n=1.739), oboje v kombinaciji z acetilsalicilno kislino (150 do 325 mg kot udarni odmerek, nato 75 do 162 mg na dan)
English: Do not take Clopidogrel Teva Pharma B.V.
Bulgarian: Ne jemljite zdravila Klopidogrel Teva Pharma B.V.
English: United Kingdom Teva UK Limited Tel: +44 (0) 1977 628500
Bulgarian: Tel: +44 (0) 1977 628500
English: Hepatic impairment
Bulgarian: Ušesne bolezni vrtoglavica
English: Other medicines and Clopidogrel Teva Pharma B.V.
Bulgarian: Druga zdravila in zdravilo Kopidogrel Teva Pharma B.V.
English: Recent ischaemic stroke
Bulgarian: Nedavna ishemična kap
English: Mean peak plasma levels of unchanged clopidogrel (approximately 2.2-2.5 ng/ml after a single 75 mg oral dose) occurred approximately 45 minutes after dosing.
Bulgarian: Povprečna največja koncentracija nespremenjenega klopidogrela v plazmi (približno 2,2-2,5 ng/ml po enem 75-mg peroralnem odmerku)
English: Bleeding
Bulgarian: Krvavitev
English: In COMMIT, the overall rate of noncerebral major bleeding or cerebral bleeding was low and similar in both groups.
Bulgarian: skupni delež večjih necerebralnih krvavitev ali cerebralne krvavitve nizek
English: The dose of 0.2 mg/kg achieved the mean percent inhibition of 49.3% (5 µM ADP-induced platelet aggregation) which was comparable to that of adults taking clopidogrel 75 mg/day.
Bulgarian: Odmerek 0,2 mg/kg je dosegel povprečno 49,3 % zavrtje (agregacija trombocitov povzročena
English: • You have an irregular heartbeat, a condition called ‘atrial fibrillation', and you cannot take medicines known as ‘oral anticoagulants' (vitamin K antagonists) which prevent new clots from forming and prevent existing clots from growing.
Bulgarian: imate neredno bitje srca, motnjo, imenovano "atrijska fibrilacija", in ne morete prejemati zdravil, imenovanih "peroralni antikoagulanti" (antagonisti vitamina K), ki preprečujejo nastajanje novih krvnih strdkov in preprečujejo rast obstoječih krvnih strdkov. Povedati so vam morali, da so "peroralni antikoagulanti" pri tej motnji učinkovitejši kot acetilsalicilna kislina ali kombinirana uporaba zdravila Klopidogrel Teva Pharma B.V.
English: Serious haemorrhage, haemorrhage of operative wound, vasculitis, hypotension
Bulgarian: Žilne bolezni hematom resne krvavitve, krvavitev operacijske rane, vaskulitis, hipotenzija
English: What is in this leaflet
Bulgarian: Kaj vsebuje navodilo
English: • Altered behaviour, headaches, coma, visual disturbances, seizures (fitting), kidney failure, fever, extreme tiredness, weakness or bleeding into the stomach, bowels or skin (including small red spots or large bruised areas).
Bulgarian: spremembe vedenja, glavoboli, koma, motnje vida, napadi (krči), odpovedovanje ledvic, povišana telesna temperatura, huda utrujenost, šibkost ali krvavitve iz želodca, črevesja ali kože (vključno z manjšimi rdečimi madeži ali večjimi odrgninami).
English: Blood and the lymphatic system disorders
Bulgarian: Bolezni krvi in limfatičnega sistema nevtropenija, vključno
English: Because the active metabolite is formed by CYP450 enzymes, some of which are polymorphic or subject to inhibition by other medicinal products, not all patients will have adequate platelet inhibition.
Bulgarian: so nekateri polimorfni ali podvrženi zavrtju z drugimi zdravili, se ustrezno zavrtje trombocitov ne pojavi pri vseh bolnikih.
English: Therapeutic experience with clopidogrel is limited in patients with renal impairment.
Bulgarian: so pri bolnikih z ledvično okvaro omejene.
English: Adverse reactions that occurred either during clinical studies or that were spontaneously reported are presented in the table below.
Bulgarian: Neželene reakcije, ki so se pojavile v kliničnih študijah ali o katerih
English: The plasma concentrations of the active metabolite was 20% reduced (loading dose) and 14% reduced (maintenance dose) during concomitant treatment with pantoprazole 80 mg once daily.
Bulgarian: Pri sočasni uporabi 80 mg pantoprazola enkrat dnevno, so se zmanjšale plazemske koncentracije aktivnega presnovka za 20 % (začetni odmerek) in 14 % (vzdrževalni odmerek), z zmanjšanjem zavrtja agregacije trombocitov za 15 % in 11 %. Ti rezultati kažejo, da se klopidogrel lahko uporablja skupaj s pantoprazolom.
English: There was no statistically significant difference in the rates of fatal bleeding (1.1% in the clopidogrel + ASA group and 0.7% in the placebo +ASA group) and haemorrhagic stroke (0.8% and 0.6%, respectively) between groups.
Bulgarian: statistično značilne razlike v deležih krvavitev s smrtnim izidom (1,1 % klopidogrel + acetilsalicilna kislina, 0,7 % placebo + acetilsalicilna kislina)
English: Clopidogrel should therefore be used with caution in this population (see section 4.2).
Bulgarian: Zato je potrebno pri tej skupini bolnikov klopidogrel uporabljati previdno (glejte poglavje 4.2).
English: D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND
Bulgarian: POGOJI ALI OMEJITVE V ZVEZI
English: BATCH NUMBER
Bulgarian: ŠTEVILOM ENOT
English: Strokes occurred in 296 (7.8%) patients receiving clopidogrel + ASA and 408 (10.8%) patients receiving placebo + ASA (relative risk reduction, 28.4%; 95% CI, 16.8% to 38.3%; p=0.00001).
Bulgarian: se je pojavila pri 296 (7,8 %) bolnikih, ki so prejemali klopidogrel + acetilsalicilno kislino, in pri 408 (10,8 %) bolnikih, ki so prejemali placebo + acetilsalicilno kislino (relativno zmanjšanje
English: The active substance is clopidogrel.
Bulgarian: Zdravilna učinkovina je klopidogrel.
English: Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Bulgarian: in omeprazol uporabljena skupaj istočasno ali v presledku 12 ur, se je izpostavljenost aktivnemu presnovku klopidogrela zmanjšala za 45 % (začetni odmerek) oz.
English: Fifteen percent (15.0%) of patients in the clopidogrel group and 21.7% in the placebo group reached the primary endpoint, representing an absolute reduction of 6.7% and a 36% odds reduction in favor of clopidogrel (95% CI: 24, 47%; p<0.001), mainly related to a reduction in occluded infarct-related arteries.
Bulgarian: s placebom, kar predstavlja absolutno zmanjšanje za 6,7 % in 36 % zmanjšanje verjetnosti v prid klopidogrela (95 % IZ od 24 % do 47 %; p<0,001) v glavnem zaradi zmanjšanja pojavnosti zaradi infarkta zamašenih arterij.
English: Taste disturbances
Bulgarian: motnje okušanja,
English: Clopidogrel active metabolite pharmacokinetics and antiplatelet effects, as measured by ex vivo platelet aggregation assays, differ according to CYP2C19 genotype.
Bulgarian: s preskusi agregacije trombocitov ex vivo, se razlikuje glede na genotip CYP2C19.
English: - For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.
Bulgarian: - če je zamuda več kot 12 ur: bolnik naj naslednji odmerek vzame ob pravem času;
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 2 or section
Bulgarian: Preobčutljivost na zdravilno učinkovino ali katero koli pomožno snov, nevedno v poglavju 6.1.
English: No clinically significant pharmacodynamic interactions were observed when clopidogrel was co administered with atenolol, nifedipine, or both atenolol and nifedipine.
Bulgarian: Pri sočasni uporabi klopidogrela z atenololom, nifedipinom, ali z obema - atenololom in nifedipinom - niso opazili nobenih klinično pomembnih farmakodinamičnih interakcij.
English: The use of clopidogrel in CURE was associated with a decrease in the need of thrombolytic therapy (RRR=43.3%; CI: 24.3%, 57.5%) and GPIIb/IIIa inhibitors (RRR=18.2%; CI: 6.5%, 28.3%).
Bulgarian: in inhibitorji glikoproteinov IIb/IIIa (zmanjšanje RT =18,2 %; IZ: 6,5 %, 28,3 %).
English: Clopidogrel Teva Pharma B.V. contains lactose
Bulgarian: Zdravilo Klopidogrel Teva Pharma B.V. vsebuje laktozo
English: Fertility Clopidogrel was not shown to alter fertility in animal studies.
Bulgarian: Plodnost Šudije na živalih niso pokazale, da bi klopidogrel vplival na plodnost.
English: 30 tablets HDPE bottle:
Bulgarian: HDPE steklenička po 30 tablet:
English: See leaflet for further information
Bulgarian: Za dodatne informacije glejte navodilo za uporabo.
English: The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Bulgarian: Aktivni presnovek klopidogrela selektivno zavira vezavo adenozin-difosfata (ADP) na njegov trombocitni receptor P2Y12
English: Each film-coated tablet contains 75 mg of clopidogrel (as hydrobromide).
Bulgarian: Ena filmsko obložena tableta vsebuje 75 mg klopidogrela (v
English: In patients who were enrolled in the trial on the sole basis of a recent myocardial infarction, clopidogrel was numerically inferior, but not statistically different from ASA (RRR=-4.0%; CI: -22.5 to 11.7 [p=0.639]).
Bulgarian: se statistično ni razlikoval od acetilsalicilne kisline (zmanjšanje RT=4,0 %; IZ: -22,5 do 11,7 [p=0,639]).
English: Clopidogrel Teva Pharma B.V. is supplied in peelable perforated blisters of aluminium/ aluminium containing 14x1, 28x1, 30x1, 50x1, 84x1, 90x1 or 100x1 tablet; perforated blisters of aluminium/ aluminium containing 14x1, 28x1, 30x1, 50x1, 84x1, 90x1 or 100x1 tablet or HDPE bottles with polypropylene closures or child resistant polypropylene closures and silica gel desiccant containing 30 or 100 tablets.
Bulgarian: Zdravilo Klopidogrel Teva Pharma B.V. je na voljo v perforiranih pretisnih omotih iz aluminija, ki se odlepijo, in sicer po 14x1, 28x1, 30x1, 50x1, 84x1, 90x1 ali 100x1 tablet; ter perforiranih pretisnih omotih iz aluminija, in sicer po 14x1, 28x1, 30x1, 50x1, 84x1, 90x1 ali 100x1
English: Clopidogrel Teva Pharma B.V. 75 mg film-coated tablets clopidogrel
Bulgarian: Klopidogrel Teva Pharma B.V. 75 mg filmsko obložene tablete klopidogrel
English: Breast-feeding
Bulgarian: Klopidogrel
English: Teva Pharma B.V.,
Bulgarian: Z ZDRAVILOM Teva Pharma B.V.
English: Clopidogrel Teva Pharma B.V. contains lactose.
Bulgarian: Zdravilo Klopidogrel Teva Pharma B.V. vsebuje laktozo.
English: MARKETING AUTHORISATION HOLDER
Bulgarian: IME IMETNIKA DOVOLJENJA
English: Luxembourg/Luxemburg ratiopharm GmbH Allemagne/Deutschland Tél/Tel: +49 731 402 02
Bulgarian: Luxembourg/Luxemburg ratiopharm GmbH Allemagne/Deutschland
English: You have been prescribed Clopidogrel Teva Pharma B.V. because:
Bulgarian: Zdravilo Klopidogrel Teva Pharma B.V. vam je bilo predpisano v naslednjih primerih:
English: Push the tablet out
Bulgarian: Navodila za odstranjevanje tablet
English: The CYP2C19*2 and CYP2C19*3 alleles account for the majority of reduced function alleles in Caucasian (85%) and Asian (99%) poor metabolisers.
Bulgarian: gre večina alelov z zmanjšanim delovanjem pri Kavkazijcih(85%) in pri Azijcih (99 %), ki so slabi metabolizatorji.
English: 30 tablets HDPE bottles:
Bulgarian: HDPE stekleničke po 30 tablet:
English: Uncommon side effects (may affect up to 1 in 100 people):
Bulgarian: Občasni neželeni učinki (pojavijo se lahko pri največ 1 od 100 bolnikov):
English: New cardiovascular events (primary endpoint) were prevented, with relative risk reductions of 22% (CI: 8.6, 33.4), 32% (CI: 12.8, 46.4), 4% (CI: -26.9, 26.7), 6% (CI: -33.5, 34.3) and 14% (CI: -31.6, 44.2), during the 0-1, 1-3, 3-6, 6-9 and 9-12 month study intervals, respectively.
Bulgarian: so preprečili z zmanjšanjem relativnega tveganja: 22 % v 0. - 1. mesecu (IZ: 8,6, 33,4), 32 % v 1.
English: In ACTIVE-A, the rate of major bleeding was greater in the clopidogrel + ASA group than in the placebo + ASA group (6.7% versus 4.3%).
Bulgarian: s placebom + acetilsalicilno kislino (6,7 % v primerjavi s 4,3 %).
English: While you are taking Clopidogrel Teva Pharma B.V.:
Bulgarian: Ko jemljete zdravilo Klopidogrel Teva Pharma B.V.:
English: Bullous dermatitis (toxic epidermal necrolysis, Stevens Johnson Syndrome, erythema multiforme), angioedema, drug-induced hypersensitivity syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), rash erythematous or exfoliative, urticaria, eczema, lichen planus
Bulgarian: Bolezni kože in podkožja bulozni dermatitis (toksična epidermalna nekroliza, StevensJohnsonov sindrom, multiformni eritem), angioedem, z zdravili povzročen
English: Clopidogrel is first metabolised to a 2-oxo-clopidogrel intermediate metabolite.
Bulgarian: Klopidogrel se najprej presnovi v 2-oksoklopidogrel, ki je vmesen presnovek.
English: - ST segment elevation acute myocardial infarction: clopidogrel should be given as a single daily dose of 75 mg initiated with a 300-mg loading dose in combination with ASA and with or without thrombolytics.
Bulgarian: - Akutni miokardni infarkt z elevacijo ST spojnice: klopidogrel je potrebno dajati v enkratnem dnevnem odmerku 75 mg, zdravljenje pa je potrebno začeti
English: 100 tablets HDPE bottles:
Bulgarian: HDPE stekleničke po 100 tablet:
English: - Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), including patients undergoing a stent placement following percutaneous coronary intervention, in combination with acetylsalicylic acid (ASA) - ST segment elevation acute myocardial infarction, in combination with ASA in medically treated patients eligible for thrombolytic therapy.
Bulgarian: Q zobca), vključno z bolniki, katerim je bil vstavljen stent po perkutani koronarni intervenciji, v kombinaciji z acetilsalicilno kislino (ASA - acetylsalicylic acid).
English: If you forget to take a dose of Clopidogrel Teva Pharma B.V., but don't remember within 12 hours of the missed dose, skip the missed dose and take the next tablet at the usual time.
Bulgarian: spomnite po več kot 12 urah, izpustite pozabljeni odmerek in naslednji odmerek vzemite ob običajnem času.
English: Film-coating
Bulgarian: s klopidogrelom
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Clopidogrel Teva Pharma B.V. 75 mg film-coated tablets clopidogrel oral use
Bulgarian: IME ZDRAVILA IN POT(I) UPORABE Klopidogrel Teva Pharma B.V. 75 mg filmsko obložene tablete klopidogrel peroralna uporaba
English: The elimination half-life of the main circulating (inactive) metabolite was 8 hours after single and repeated administration.
Bulgarian: in približno 46 % z blatom v 120 urnem intervalu po odmerjanju. Po enem peroralnem odmerku 75 mg je razpolovni čas klopidogrela približno 6 ur. Razpolovni čas izločanja glavnega (neaktivnega) krožečega metabolita je bil 8 ur po enkratnem in večkratnem dajanju.
English: Acquired haemophilia has been reported following use of clopidogrel.
Bulgarian: Po uporabi klopidogrela je bila opisana pridobljena hemofilija.
English: Acquired haemophilia
Bulgarian: Pridobljena hemofilija
English: • Ticlopidine, other antiplatelet agent.
Bulgarian: tiklopidin, druga antiagregacijska zdravila,