FrancophonIA/ELRC3.0 huggingface dataset:
English: Grastofil is used to treat children and adolescents who are receiving chemotherapy or who suffer from severe low white blood cell count (neutropenia).
Slovenian: Zdravilo Grastofil se uporablja za zdravljenje otrok in mladostnikov, ki prejemajo kemoterapijo ali imajo zelo malo belih krvnih celic (nevtropenijo).
English: A subset of approximately 12% of patients who had normal cytogenetic evaluations at baseline was subsequently found to have abnormalities, including monosomy 7, on routine repeat evaluation.
Slovenian: V podskupini približno 12 % bolnikov, ki so imeli na začetku normalen citogenetski izvid, so pozneje med rednimi ponovnimi pregledi ugotovili nepravilnosti, vključno z monosomijo 7.
English: Congenital, idiopathic or cyclic neutropenia: Grastofil should be given by subcutaneous injection.
Slovenian: Prirojena, idiopatska ali ciklična nevtropenija: Grastofil je treba dati s subkutano injekcijo.
English: In some SCN patients, filgrastim can also induce a minor increase in the number of circulating eosinophils and basophils relative to baseline; some of these patients may present with eosinophilia or basophilia already prior to treatment.
Slovenian: Pri nekaterih bolnikih s hudo kronično nevtropenijo lahko filgrastim nekoliko poveča tudi število eozinofilcev in bazofilcev v obtoku v primerjavi z izhodiščno vrednostjo; nekateri izmed teh bolnikov imajo lahko eozinofilijo ali bazofilijo že pred zdravljenjem.
English: Offspring of rats administered filgrastim during the peri-natal and lactation periods, exhibited a delay in external differentiation and growth retardation (≥20 μg/kg/day) and slightly reduced survival rate (100 μg/kg/day).
Slovenian: Pri potomcih podgan, ki so prejemale filgrastim v perinatalnem obdobju in med dojenjem, so zabeležili zaostanek pri zunanji diferenciaciji in zastoj v rasti (≥ 20 mikrogramov/kg/dan) ter nekoliko zmanjšano stopnjo preživetja (100 mikrogramov/kg/dan).
English: When administered for PBPC mobilisation, filgrastim should be discontinued or its dosage should be reduced if the leukocyte counts rise to > 70 x 10
Slovenian: Pri dajanju za izplavljanje PBPC, je treba z zdravljenjem s filgrastimom prenehati ali zmanjšati odmerek, če število levkocitov preseže vrednost > 70 x 10
English: Use of filgrastim, either alone, or after chemotherapy, mobilises haematopoietic progenitor cells into peripheral blood.
Slovenian: Uporaba filgrastima samega ali po kemoterapiji izplavi krvotvorne matične celice v periferno kri.
English: Filgrastim should not be used to increase the dose of cytotoxic chemotherapy beyond established dosage regimens.
Slovenian: Filgrastima se ne sme uporabljati za povečanje odmerka citotoksične kemoterapije zunaj uveljavljenih shem odmerjanja.
English: Special warning and precautions associated with co-morbidities
Slovenian: Posebna opozorila in previdnostni ukrepi, povezani s sočasnimi boleznimi
English: Granulocyte-colony stimulating factor can promote growth of myeloid cells in vitro and similar effects may be seen on some non-myeloid cells in vitro.
Slovenian: Granulocitne kolonije stimulirajoči faktor lahko in vitro spodbuja rast mieloičnih celic; podobne učinke so in vitro opazili tudi pri nekaterih nemieloičnih celicah.
English: Do not shake the pre-filled syringe.
Slovenian: Ne stresajte napolnjene brizge.
English: Pull slightly on the plunger to check that a blood vessel has not been punctured.
Slovenian: Nekoliko izvlecite bat, da preverite, da krvna žila v koži ni bila predrta.
English: 9/L) following filgrastim administration and leukapheresis was observed in 35% of subjects studied.
Slovenian: 9/l) so po dajanju filgrastima in levkaferezi ugotovili pri 35 % preučevanih oseb.
English: In clinical studies, 97% of patients who responded had a complete response at doses of ≤ 2.4 MU/kg/day (24 micrograms/kg/day).
Slovenian: V kliničnih preskušanjih so pri 97 % bolnikov, ki so se odzivali, dosegli popoln odziv z odmerki ≤ 2,4 M e./kg/dan (24 mikrogramov/kg/dan).
English: A diagnosis of splenic rupture should be considered in donors and/or patients reporting left upper abdominal or shoulder tip pain.
Slovenian: Na raztrganje vranice je treba pomisliti pri darovalcih in/ali bolnikih, ki navajajo bolečino v levem zgornjem delu trebuha ali na vrhu rame.
English: The effects of filgrastim in patients with substantially reduced myeloid progenitors have not been studied.
Slovenian: Učinki filgrastima pri bolnikih z znatno zmanjšanim številom matičnih celic mieloične vrste niso bili raziskani.
English: Disinfect your skin by using an alcohol wipe and pinch (without squeezing) the skin between your thumb and forefinger.
Slovenian: Razkužite kožo z alkoholno krpico in primite (brez stiskanja) kožo s palcem in kazalcem.
English: If needed, you may cover the injection site with a plaster.
Slovenian: Če je potrebno, ga lahko pokrijete z obližem.
English: Example: In a final injection volume of 20 mL, total doses of filgrastim less than 30 MU (300 µg) should be given with 0.2 mL of 200 mg/mL (20%) human albumin solution added.
Slovenian: Primer: Če je končna količina za injiciranje 20 ml, je treba vsem odmerkom filgrastima, manjšim od 30 M e. (300 mikrogramov), dodati 0,2 ml 200 mg/ml (20-odstotne) raztopine humanega serumskega albumina.
English: Within its shelf-life and for the purpose of ambulatory use, the patient may remove Grastofil from the refrigerator and store it at room temperature (not above 25°C) for one single period of up to 15 days.
Slovenian: Znotraj roka uporabnosti lahko pri ambulantni uporabi bolnik vzame zdravilo Grastofil iz hladilnika in ga hrani pri sobni temperaturi (do 25 °C) za enkratno obdobje do največ 15 dni.
English: In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1-2 days after initiation of Grastofil therapy.
Slovenian: Pri bolnikih, ki prejemajo citotoksično kemoterapijo, se 1-2 dni po začetku zdravljenja z Grastofilom običajno pojavi začasno povečanje števila nevtrofilcev.
English: For reversal of neutropenia
Slovenian: Za odpravo nevtropenije
English: Analysis includes patients receiving BM transplant during this period
Slovenian: Analiza vključuje bolnike, ki so prejeli presadek kostnega mozga v tem časovnem obdobju
English: Grastofil is a clear colourless solution for injection or infusion.
Slovenian: Zdravilo Grastofil je bistra, brezbarvna raztopina za injiciranje ali infundiranje.
English: • a new pre-filled syringe of Grastofil; and
Slovenian: • novo napolnjeno injekcijsko brizgo Grastofil in
English: Filgrastim acts primarily on neutrophil precursors to exert its effect in elevating neutrophil counts.
Slovenian: Filgrastim deluje predvsem na predhodnike nevtrofilcev in učinkuje tako, da poveča število nevtrofilcev.
English: Special warnings and precautions across indications
Slovenian: Posebna opozorila in previdnostni ukrepi za vse indikacije
English: Telephone +421/2-5262.1933
Slovenian: Tel: +421/2-5262.1933
English: The recommended starting dose of Grastofil is 0.1 MU/kg/day (1 micrograms/kg/day) with titration up to a maximum of 0.4 MU/kg/day (4 micrograms/kg/day) until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 10
Slovenian: Priporočeni začetni odmerek Grastofila je 0,1 M e./kg/dan (1 mikrogram/kg/dan) s titriranjem do največ 0,4 M e./kg/dan (4 mikrogrami/kg/dan) dokler se ne doseže in ne vzdržuje normalno število nevtrofilcev (ANC > 2,0 x 10
English: Tell your doctor immediately during treatment if:
Slovenian: Med zdravljenjem takoj povejte zdravniku, če:
English: STADA Nordic ApS Telephone +45/44.85.99.99
Slovenian: STADA Nordic ApS Tel:+45/44.85.99.99
English: Dose adjustment: Grastofil should be administered daily by subcutaneous injection until the neutrophil count has reached and can be maintained at more than 1.5 x 10
Slovenian: Prilagoditev odmerka: Grastofil je treba dajati vsak dan s subkutano injekcijo, dokler število nevtrofilcev ne preseže vrednosti 1,5 x 10
English: Grastofil therapy should only be given in collaboration with an oncology centre which has experience in granulocyte-colony stimulating factor (G-CSF) treatment and haematology and has the necessary diagnostic facilities.
Slovenian: Zdravljenje z zdravilom Grastofil se lahko predpiše samo v sodelovanju z onkološkim centrom, ki ima izkušnje na področju zdravljenja s faktorji, ki spodbujajo rast granulocitnih kolonij (G-CSFgranulocyte-colony stimulating factor) in hematologije, in ki razpolaga z ustreznimi diagnostičnimi pripomočki.
English: A common side effect of Grastofil use is pain in your muscles or bones (musculoskeletal pain), which can be helped by taking standard pain relief medicines (analgesics).
Slovenian: Pogost neželeni učinek zdravila Grastofil so bolečine v mišicah in kosteh (mišično-skeletne bolečine), ki jih je mogoče olajšati z jemanjem običajnih protibolečinskih zdravil (analgetikov).
English: Leukapheresis should not be performed in donors who are anticoagulated or who have known defects in haemostasis.
Slovenian: Levkafereze se ne sme narediti pri darovalcih, ki se zdravijo z antikoagulansi, ali imajo znane motnje v hemostazi.
English: • you experience kidney injury (glomerulonephritis).
Slovenian: • se vam pojavi poškodba ledvic (glomerulonefritis).
English: Patients with a recent history of lung infiltrates or pneumonia may be at higher risk.
Slovenian: Bolniki, ki so v bližnji preteklosti imeli pljučne infiltrate ali pljučnico, so morda bolj ogroženi.
English: Your doctor will tell you how much Grastofil you should take.
Slovenian: Zdravnik vam bo povedal, koliko zdravila Grastofil morate uporabiti.
English: To avoid bending the needle, gently pull the cover from the needle without twisting.
Slovenian: Da ne boste zvili igle, previdno potegnite pokrovček igle, ne da bi ga zavrteli.
English: The effects of Grastofil overdose have not been established.
Slovenian: Učinkov prevelikega odmerjanja zdravila Grastofil niso ugotavljali.
English: A diluted solution of Grastofil for infusion should be used within 24 hours when stored at 2 °C to 8 °C.
Slovenian: Razredčeno raztopino zdravila Grastofil za infundiranje uporabite v 24 urah, če jo shranjujete pri temperaturi 2 °C do 8 °C.
English: • sudden life-threatening allergic reaction (anaphylactic reaction)
Slovenian: • nenadna življenjsko nevarna alergijska reakcija (anafilaktična reakcija)
English: Special care should be taken when administering single or combination chemotherapeutic medicinal products which are known to cause severe thrombocytopenia.
Slovenian: Posebna previdnost je potrebna, kadar je predpisan en sam kemoterapevtik ali več kemoterapevtikov, za katere se ve, da povzročajo hudo trombocitopenijo.
English: Use of filgrastim in patients undergoing cytotoxic chemotherapy leads to significant reductions in the incidence, severity and duration of neutropenia and febrile neutropenia.
Slovenian: Uporaba filgrastima pri bolnikih, pri katerih se izvaja citotoksična kemoterapija, ima za posledico pomembno zmanjšanje pogostnosti pojavljanja, resnosti in trajanja nevtropenije in febrilne nevtropenije.
English: • liver damage caused by blocking of the small veins within the liver (veno-occlusive disease)
Slovenian: • poškodovanje jeter zaradi blokade majhnih žil v jetrih (venookluzivna bolezen)
English: Studies of filgrastim in patients with severe impairment of renal or hepatic function demonstrate that it exhibits a similar pharmacokinetic and pharmacodynamic profile to that seen in normal individuals.
Slovenian: Študije s filgrastimom pri bolnikih s hudo ledvično ali jetrno okvaro so pokazale, da ima zdravilo pri teh bolnikih podoben farmakokinetičen in farmakodinamičen profil kot pri običajnih posameznikih.
English: If required, Grastofil may be diluted in 5% glucose solution for injection/infusion.
Slovenian: Po potrebi se lahko zdravilo Grastofil razredči v 5-odstotni raztopini glukoze za injiciranje/infundiranje.
English: An increased incidence of embryo-loss has been observed in rabbits at high multiples of the clinical exposure and in the presence of maternal toxicity (see section 5.3).
Slovenian: Pri kuncih so opazili večjo pogostnost izgube zarodkov pri visokih večkratnikih klinične izpostavljenosti in ob prisotnosti toksičnosti za samice (glejte poglavje 5.3).
English: If you become pregnant during Grastofil treatment, please inform your doctor.
Slovenian: Če med zdravljenjem z zdravilom Grastofil zanosite, to povejte zdravniku.
English: Please tell your doctor before starting treatment if you have:
Slovenian: Pred začetkom zdravljenja zdravniku povejte, če imate:
English: Because of the potential of receiving higher doses of chemotherapy (e.g. full doses on the prescribed schedule) the patient may be at greater risk of thrombocytopenia and anaemia.
Slovenian: Zaradi možnosti prejemanja večjih odmerkov kemoterapije (npr. polnih odmerkov po predpisani shemi), je morda pri bolniku tveganje zaradi trombocitopenije in anemije večje.
English: Your doctor will perform regular blood tests to determine the best time to collect the stem cells.
Slovenian: Vaš zdravnik bo redno izvajal krvne preiskave, da ugotovi najboljši čas za odvzem matičnih celic.
English: 9/L, and a history of severe or recurrent infections, long term administration of Grastofil is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.
Slovenian: 9/l in s hudimi ali ponavljajočimi se okužbami v anamnezi je indicirana dolgotrajna uporaba zdravila Grastofil za povečanje števila nevtrofilcev in zmanjšanje pogostnosti pojavljanja in trajanja z okužbami povezanih zapletov.
English: Then, if ANC remains > 1.0 x 10
Slovenian: Nato, če ANC ostane > 1,0 x 10
English: In a separate retrospective international study in patients with acute and chronic myelogenous leukaemias, no effect on the risk of GvHD, TRM and mortality was seen.
Slovenian: V drugi retrospektivni mednarodni študiji pri bolnikih z akutnimi in kroničnimi mielogenimi levkemijami niso opazili vpliva na tveganje za pojav GvHD, TRM in smrtnost.
English: The stem cells will then go back into the bone marrow and produce blood cells.
Slovenian: Matične celice se vrnejo v kostni mozeg, kjer proizvajajo krvne celice.
English: For maintenance of normal neutrophil counts
Slovenian: Vzdrževanje normalnega števila nevtrofilcev
English: For example, if you weigh 60 kilograms your daily dose will be 60 million units (600 micrograms).
Slovenian: Če na primer tehtate 60 kilogramov, bo vaš dnevni odmerek 60 milijonov enot (600 mikrogramov).
English: Grastofil is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs).
Slovenian: Zdravilo Grastofil je indicirano za izplavljanje krvotvornih matičnih celic v periferno kri (PBPCperipheral blood progenitor cells).
English: For example, if you weigh 60 kilograms your daily dose will be 30 million units (300 micrograms).
Slovenian: Če na primer tehtate 60 kilogramov, bo vaš dnevni odmerek 30 milijonov enot (300 mikrogramov).
English: What Grastofil looks like and contents of the pack
Slovenian: Izgled zdravila Grastofil in vsebina pakiranja
English: • pain in your mouth and throat (oropharyngeal pain)
Slovenian: • bolečine v ustih in žrelu (orofaringealne bolečine)
English: Based on reported data for another filgrastim product similar to Grastofil, comparable findings plus increased fetal malformations were observed at 100 μg/kg/day, a maternally toxic dose which corresponded to a systemic exposure of approximately 50-90 times the exposures observed in patients treated with the clinical dose of 5 μg/kg/day.
Slovenian: Na podlagi podatkov, o katerih so poročali pri drugem zdravilu s filgrastimom, podobnim zdravilu Grastofil, so zabeležili primerljive izsledke ter več malformacij ploda pri odmerku 100 mikrogramov/kg/dan, tj. pri odmerku, toksičnem za samice, ki je ustrezal sistemski izpostavljenosti, ki je približno 50- do 90-krat večja izpostavljenosti, ki so jo zabeležili pri bolnikih, ki so prejemali klinični odmerek 5 mikrogramov/kg/dan.
English: Solution for injection/infusion 1 pre-filled syringe (0.5 mL) 5 pre-filled syringes (0.5 mL)
Slovenian: raztopina za injiciranje/infundiranje 1 napolnjena injekcijska brizga (0,5 ml) 5 napolnjenih injekcijskih brizg (0,5 ml)
English: Grastofil 48 MU/0.5 mL
Slovenian: Grastofil 48 M e./0,5 ml
English: STADA Nordic ApS, Suomen sivuliike Telephone +358/207.416.888
Slovenian: STADA Nordic ApS, Suomen sivuliike Puh/Tel: +358/207.416.888
English: In view of limited safety and efficacy data in patients with secondary AML, filgrastim should be administered with caution.
Slovenian: Glede na to, da je podatkov o varnosti in učinkovitosti pri bolnikih s sekundarno akutno mieloično levkemijo malo, je treba filgrastim uporabljati previdno.
English: Your doctor will tell you how long you will need to take Grastofil.
Slovenian: Vaš zdravnik vam bo povedal, kako dolgo morate uporabljati zdravilo Grastofil.
English: If required, Grastofil may be diluted in 5% glucose.
Slovenian: Po potrebi lahko zdravilo Grastofil razredčite v 5-odstotni raztopini glukoze.
English: However, in view of the potential risks associated with severe leukocytosis, a white blood cell count should be performed at regular intervals during filgrastim therapy.
Slovenian: Zaradi možnih tveganj, povezanih s hudo levkocitozo, je treba med zdravljenjem s filgrastimom redno meriti število belih krvnih celic.
English: One retrospective European study evaluating the use of G-CSF after allogeneic bone marrow transplantation in patients with acute leukaemias suggested an increase in the risk of GvHD, treatment related mortality (TRM) and mortality when G-CSF was administered.
Slovenian: Retrospektivna evropska študija, v kateri so ocenjevali uporabo G-CSF po alogenski presaditvi kostnega mozga pri bolnikih z akutno levkemijo, je nakazala povečanje tveganja za pojav reakcije presadka proti gostitelju (GvHD - Graft versus Host Disease), z zdravljenjem povezane smrtnosti (TRM - treatment related mortality), in smrtnosti, kadar so dajali G-CSF.
English: Pack sizes: Cartons containing 1 or 5 pre-filled syringes.
Slovenian: Velikost pakiranja: škatle vsebujejo 1 ali 5 napolnjenih injekcijskih brizg.
English: Instructions for injecting Grastofil
Slovenian: Navodila za injiciranje zdravila Grastofil
English: Grastofil containing r-metHuG-CSF (filgrastim) causes marked increases in peripheral blood neutrophil counts within 24 hours, with minor increases in monocytes.
Slovenian: Zdravilo Grastofil, ki vsebuje rmetHuG-CSF (filgrastim), v 24 urah izrazito poveča število nevtrofilcev v periferni krvi; število monocitov pa se ob tem le nekoliko poveča.
English: These have generally occurred in patients with advanced malignant diseases, sepsis, using multiple chemotherapy medicinal products or undergoing apheresis (see section 4.4).
Slovenian: Do teh primerov je na splošno prihajalo pri bolnikih z napredovalimi malignimi boleznimi ali sepso ali bolnikih, ki so uporabljali več zdravil za kemoterapijo ali so bili na aferezi (glejte poglavje 4.4.)
English: Intravenous (80 μg/kg/day) administration of filgrastim to rabbits during the period of organogenesis was maternally toxic and increased spontaneous abortion, post-implantation loss, and decreased mean live litter size and fetal weight were observed.
Slovenian: Intravensko (80 mikrogramov/kg/dan) dajanje filgrastima kuncem v obdobju organogeneze je bilo toksično za samice in je povečalo število spontanih splavov ter izgub ploda po ugnezdenju, opazili pa so tudi manjšo povprečno velikost legla in maso zarodka.
English: Telephone +39/02-89.421721
Slovenian: Tel: +39/02-89.421721
English: In randomised clinical studies, a subcutaneous dose of 230 micrograms/m2/day (4.0 to 8.4 micrograms/kg/day) was used.
Slovenian: V randomiziranih kliničnih preskušanjih so uporabljali subkutani odmerek 230 mikrogramov/m2/dan (4,0 do 8,4
English: Filgrastim had no observed effect on the fertility of male or female rats.
Slovenian: Filgrastim ni opazno vplival na plodnost podganjih samcev ali samic.
English: Relative risk (95% CI) of GvHD and TRM following treatment with G-CSF after bone marrow (BM) transplantation
Slovenian: Relativno tveganje (95-odstotni IZ) za pojav reakcije presadka proti gostitelju (GvHD) in TRM po zdravljenju z G-CSF po presaditvi kostnega mozga
English: You will need to take Grastofil until your white blood cell count is normal.
Slovenian: Zdravilo Grastofil boste morali uporabljati, dokler se vam število belih krvnih celic ne normalizira.
English: • have sudden signs of allergy such as rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing as these could be signs of a severe allergic reaction (hypersensitivity).
Slovenian: • se vam pojavijo nenadni znaki alergije, kot so izpuščaj, srbečica ali koprivnica na koži, oteklost obraza, ustnic, jezika ali drugih delov telesa, kratka sapa, sopenje ali težave z dihanjem, saj so lahko to znaki hude alergijske reakcije (preobčutljivosti),
English: • experience puffiness in your face or ankles, blood in your urine or brown-coloured urine or you notice you urinate less than usual (glomerulonephritis).
Slovenian: • se vam pojavi otekanje obraza ali gležnjev, kri v urinu, rjavo obarvan urin ali če opazite, da urinirate manj kot običajno (glomerulonefritis),
English: Splenomegaly and Splenic rupture
Slovenian: Splenomegalija in raztrganje vranice
English: Since lithium promotes the release of neutrophils, it is likely to potentiate the effect of filgrastim.
Slovenian: Litij pospešuje sproščanje nevtrofilcev, zato lahko okrepi učinek filgrastima.
English: Grastofil should be given by subcutaneous injection.
Slovenian: Način uporabe Grastofil je treba dati s subkutano injekcijo.
English: Therefore, in patients with reduced precursors, neutrophil response may be diminished (such as those treated with extensive radiotherapy or chemotherapy, or those with bone marrow infiltration by tumour).
Slovenian: Zato je lahko odziv nevtrofilcev manjši pri bolnikih, ki imajo zmanjšano število predhodnikov nevtrofilcev (npr. pri bolnikih, zdravljenih z obsežno radioterapijo ali kemoterapijo, ali pri bolnikih s tumorsko infiltracijo kostnega mozga).
English: For the mobilisation of peripheral blood progenitor cells (PBPC) in patients undergoing myelosuppressive or myeloablative therapy followed by autologous PBPC transplantation
Slovenian: Za izplavljanje krvotvornih matičnih celic v periferno kri (PBPC) pri bolnikih, pri katerih se izvaja mielosupresivno ali mieloablacijsko zdravljenje, ki mu sledi avtologna presaditev PBPC
English: • pain when passing urine (dysuria)
Slovenian: • bolečine pri uriniranju (dizurija)
English: Use of filgrastim in patients, children or adults, with SCN (severe congenital, cyclic, and idiopathic neutropenia) induces a sustained increase in ANCs in peripheral blood and a reduction of infection and related events.
Slovenian: Uporaba filgrastima pri bolnikih, otrocih ali odraslih s hudo kronično nevtropenijo (huda prirojena, ciklična in idiopatska nevtropenija) povzroči dolgotrajno povečanje ANC v periferni krvi in zmanjša pogostnost okužb in z njimi povezanih zapletov.
English: • pain and swelling of the joints, similar to gout (pseudogout)
Slovenian: • bolečine in oteklost sklepov, podobne protinu (psevdoprotin)
English: These could be symptoms of a condition called “Capillary Leak Syndrome” which causes the blood to leak from the small blood vessels into your body and needs urgent medical attention.
Slovenian: Lahko gre za simptome stanja, ki se imenuje sindrom povečane prepustnosti kapilar in povzroči uhajanje krvi iz drobnih krvnih žil v vaše telo ter zahteva nujno medicinsko pomoč.
English: cells re-infused and the rate of platelet recovery after high-dose chemotherapy indicates a complex but continuous relationship.
Slovenian: in hitrostjo obnove trombocitov po kemoterapiji v velikih odmerkih kaže na zapleteno, a stalno medsebojno povezavo.