FrancophonIA/ELRC3.0 huggingface dataset:
English: Agents such as melphalan, carmustine (BCNU) and carboplatin, when administered over prolonged periods prior to attempts at progenitor mobilisation, may reduce progenitor yield.
Slovenian: Dalj časa trajajoče dajanje učinkovin kot so melfalan, karmustin (BCNU) in karboplatin pred samim poskusom izplavljanja matičnih celic lahko povzroči zmanjšanje števila izplavljenih matičnih celic.
English: Reduce to 0.5 MU (5µg) /kg/day
Slovenian: Odmerek zmanjšajte na 0,5 M e. (5 µg)/kg/dan
English: i. Pull slightly on the plunger to check that a blood vessel has not been punctured.
Slovenian: c. Nekoliko izvlecite bat, da preverite, da krvna žila v koži ni bila predrta.
English: Thirty-one percent (31%) of patients in studies were documented as having palpable splenomegaly.
Slovenian: V študijah so dokumentirali, da je imelo 31% bolnikov tipljivo splenomegalijo.
English: INFORMATION IN BRAILLE Accofil 48 MU/0.5 ml
Slovenian: PODATKI V BRAILLOVI PISAVI Accofil 48 M e./0,5 ml
English: • Osteoporosis (bone disease)
Slovenian: • če imate osteoporozo (bolezen kosti).
English: The first dose of filgrastim should be administered at least 24 hours after cytotoxic chemotherapy and at least 24 hours after bone marrow infusion.
Slovenian: Prvi odmerek filgrastima je treba dati vsaj 24 ur po citotoksični kemoterapiji, vsaj 24 ur po infuziji kostnega mozga.
English: Accofil and neutropenia (low number of a type of white blood cells) in patients with HIV infection
Slovenian: Zdravilo Accofil in nevtropenija (nizko število vrste belih krvnih celic) pri bolnikih, okuženih s HIV
English: If the ANC decreases to < 1.0 x 109/L during the treatment period, the dose of filgrastim should be re-escalated according to the above steps
Slovenian: Prekinite zdravljenje s filgrastimom Če se ANC med obdobjem zdravljenja zmanjša na < 1,0 x 109/L, je treba odmerek filgrastima ponovno povečevati v skladu z zgoraj navedenimi koraki ANC = absolutno število nevtrofilcev
English: Analysis includes studies involving BM transplant during this period; some studies used GM-CSF Analysis includes patients receiving BM transplant during this period Use of filgrastim for the mobilisation of PBPCs in normal donors prior to allogeneic PBPC transplantation
Slovenian: b aAnaliza vključuje študije v zvezi s presaditvijo kostnega mozga v tem časovnem obdobju; v nekaterih študijah je bila uporabljena GM-CSF Analiza vključuje bolnike, ki so prejeli presadek kostnega mozga v tem časovnem obdobju
English: During long term use cutaneous vasculitis has been reported in 2% of SCN patients.
Slovenian: Ob dolgoročni uporabi so o kožnem vaskulitisu poročali pri 2 % bolnikov s hudo kronično nevtropenijo.
English: 1 pre-filled syringe (0.5 ml) + 1 alcohol swab “3 pre-filled syringe (0.5 ml) + 3 alcohol swabs” “5 pre-filled syringes (0.5 ml) + 5 alcohol swabs” “10 pre-filled syringe (0.5 ml) + 10 alcohol swabs” “7 pre-filled syringe (0.5 ml) + 7 alcohol swabs”
Slovenian: 1 napolnjena injekcijska brizga (0,5 ml) + 1 alkoholna krpica “3 napolnjene injekcijske brizge (0,5 ml) + 3 alkoholne krpice” “5 napolnjenih injekcijskih brizg (0,5 ml) + 5 alkoholnih krpic” “10 napolnjenih injekcijskih brizg (0,5 ml) + 10 alkoholnih krpic” “7 napolnjenih injekcijskih brizg (0,5 ml) + 7 alkoholnih krpic”
English: Accofil must not be diluted with sodium chloride solutions.
Slovenian: Zdravila Accofil ne smemo mešati z raztopinami natrijevega klorida.
English: j. Inject only the dose your doctor has told you following the instructions below.
Slovenian: j. Po navodilih spodaj si injicirajte samo odmerek, ki vam ga je predpisal zdravnik.
English: If leukocyte counts exceed 50 x 109/L after the expected nadir, filgrastim should be discontinued immediately.
Slovenian: Če število belih krvnih celic po pričakovanem padcu nato preseže vrednost 50 × 109/L, je treba z zdravljenjem s filgrastimom takoj prenehati.
English: In patients with mobilisation of PBPC
Slovenian: Bolniki z izplavljanjem PBPC
English: Acetic acid, sodium hydroxide, sorbitol (E420), polysorbate 80, and water for injection.
Slovenian: Koncentrirana ocetna kislina, natrijev hidroksid, sorbitol (E420), polisorbat 80 in voda za injekcije.
English: Hypersensitivity, including anaphylactic reactions, occurring on initial or subsequent treatment have been reported in patients treated with filgrastim.
Slovenian: Preobčutljivost Preobčutljivost, vključno z anafilaktičnimi reakcijami, se je pojavila na začetku ali v nadaljevanju zdravljenja pri bolnikih, ki so prejemali zdravljenje s filgrastimom.
English: How to use Accofil
Slovenian: Kako uporabljati zdravilo Accofil
English: Dose reductions were noted to slow or stop the progression of splenic enlargement and in 3% of patients a splenectomy was required.
Slovenian: Zmanjšanje odmerkov je upočasnilo ali ustavilo povečevanje vranice, pri 3% bolnikov pa je bila potrebna splenektomija.
English: The recommended starting dose is 1.2 MU (12 µg)/kg/day as a single dose or in divided doses.
Slovenian: Priporočeni začetni odmerek je 1,2 M e. (12 µg)/kg/dan v enkratnem odmerku ali v deljenih odmerkih.
English: The most commonly reported adverse reactions are pyrexia, musculoskeletal pain (which includes bone pain, back pain, arthralgia, myalgia, pain in extremity, musculoskeletal pain, musculoskeletal chest pain, neck pain), anaemia, vomiting, and nausea.
Slovenian: Neželeni učinki, o katerih so najpogosteje poročali, so pireksija, mišično-skeletna bolečina (ki vključuje bolečino v kosteh, bolečino v hrbtu, artralgijo, mialgijo, bolečino v okončinah, mišičnoskeletno bolečino, mišično-skeletno bolečino v prsih, bolečino v vratu), anemija, bruhanje in navzea.
English: Accofil and bone marrow transplantation
Slovenian: Accofil in presaditev kostnega mozga
English: In patients with known bone marrow-infiltrating infections or malignancy, consider appropriate therapy for treatment of the underlying condition in addition to administration of filgrastim for treatment of neutropenia.
Slovenian: Pri bolnikih z znano infiltracijo okužbe ali malignim obolenjem v kostni mozeg je treba poleg filgrastima za zdravljenje nevtropenije ustrezno zdraviti tudi osnovno bolezen.
English: Accidental exposure to freezing temperatures for up to 24 hours does not affect the stability of Accofil.
Slovenian: Naključna do 24-urna izpostavljenost temperaturam v območju zmrzišča nima neugodnega vpliva na stabilnost zdravila Accofil.
English: Patients who have undergone very extensive prior myelosuppressive therapy may not show sufficient mobilisation of PBPC to achieve the recommended minimum yield (2.0 x 106 CD34+ cells/kg) or acceleration of platelet recovery to the same degree.
Slovenian: Pri bolnikih, ki so prejemali zelo obsežno predhodno mielosupresivno zdravljenje, se lahko zgodi, da izplavljanje PBPC ne zadošča za doseganje priporočenega najmanjšega deleža celic (2,0 x 106 celic
English: The recommended starting dose of filgrastim is 0.1 MU (1 µg )/kg/day given daily with titration up to a maximum of 0.4 MU (4 µg )/kg/day until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 109/L).
Slovenian: Priporočeni začetni odmerek filgrastima je 0,1 M e. (1 µg)/kg/dan, ki se daje vsakodnevno, s titriranjem do največ 0,4 M e. (4 µg)/kg/dan dokler se ne doseže in ne vzdržuje normalno število nevtrofilcev (ANC > 2,0 x 109/L).
English: Example: In a final injection volume of 20 ml, total doses of filgrastim less than 30 MU (300 µg) should be given with 0.2 ml of 200 mg/ml (20%) human albumin solution added.
Slovenian: Primer: Če je končna količina za injiciranje 20 ml, je treba vsem odmerkom filgrastima, manjšim od 30 M e. (300 mikrogramov), dodati 0,2 ml humanega serumskega albumina 200 mg/ml (20%) raztopine.
English: Cases of Sweets syndrome (acute febrile dermatosis) have been reported in the post-marketing setting.
Slovenian: V obdobju trženja so poročali o primerih Sweetovega sindroma (akutna febrilna dermatoza).
English: Discontinuation of filgrastim therapy usually results in a 50% decrease in circulating neutrophils within 1 to 2 days, with a return to normal levels in 1 to 7 days.
Slovenian: Po koncu zdravljenja s filgrastimom se število nevtrofilcev v obtoku v 1 do 2 dneh zmanjša za 50 %, na normalno raven pa se povrne v 1 do 7 dneh.
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the pre-filled syringe after EXP.
Slovenian: Zdravila Accofil ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na zunanji ovojnini in na napolnjeni injekcijski brizgi poleg oznake EXP. Datum izteka roka uporabnosti se izteče na zadnji dan navedenega meseca.
English: The recommended starting dose of filgrastim is 0.1 MU (1 µg)/kg/day, with titration up to a maximum of 0.4 MU (4 µg)/kg/day until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 109/L).
Slovenian: Priporočeni začetni odmerek filgrastima je 0,1 M e. (1 µg)/kg/dan, ki se daje vsakodnevno, s titriranjem do največ 0,4 M e. (4 µg) /kg/dan dokler se ne doseže in ne vzdržuje normalno število nevtrofilcev (ANC > 2,0 x 109/L).
English: Put the used syringe in the disposal container.
Slovenian: g. Uporabljeno injekcijsko brizgo dajte v poseben vsebnik za odlaganje.
English: Accofil contains the active ingredient filgrastim.
Slovenian: Zdravilo Accofil vsebuje zdravilno učinkovino filgrastim.
English: Proteinuria Urine abnormality Glomerulonephr
Slovenian: Bolezni sečil disuria hematurija proteinurija nenormal nosti urina glomerul onefritis
English: Accidental one-time exposure to freezing temperatures does not adversely affect the stability of Accofil.
Slovenian: Nenamerna enkratna izpostavljenost temperaturam v območju zmrzišča, nima vpliva na stabilnost zdravila Accofil.
English: Regular urinalysis should be performed to monitor this event.
Slovenian: Za spremljanje tega pojava je treba redno izvajati preiskave seča.
English: Dilution to a final concentration less than 0.2 MU (2 µg) per ml is not recommended at any time.
Slovenian: Raztopine ni nikoli priporočljivo razredčiti na končno koncentracijo, manjšo od 0,2 M e. (2 mikrograma) na mililiter.
English: 1 pre-filled syringe (0.5 ml) + 1 alcohol swab “5 pre-filled syringes (0.5 ml) + 5 alcohol swabs” “3 pre-filled syringe (0.5 ml) + 3 alcohol swabs” “10 pre-filled syringe (0.5 ml) + 10 alcohol swabs”
Slovenian: 1 napolnjena injekcijska brizga (0,5 ml) + 1 alkoholna krpica “5 napolnjenih injekcijskih brizg (0,5 ml) + 5 alkoholnih krpic ” “3 napolnjene injekcijske brizge (0,5 ml) + 3 alkoholne krpice” “10 napolnjenih injekcijskih brizg (0,5 ml) + 10 alkoholnih krpic”
English: Pull slightly on the plunger to check that a blood vessel has not been punctured.
Slovenian: i. Nekoliko izvlecite bat, da preverite, da krvna žila v koži ni bila predrta.
English: Cases of capillary leak syndrome have been reported in the post marketing setting with granulocyte colony-stimulating factor use.
Slovenian: Sindrom povečane prepustnosti kapilar O primerih sindroma povečane prepustnosti kapilar so poročali v okviru izkušenj po začetku trženja ob uporabi granulocitne kolonije spodbujajočega faktorja.
English: l. After injecting the liquid, remove the needle while keeping the syringe at the same angle and maintaining pressure on the plunger, then let go of your skin.
Slovenian: l. Po injiciranju odstranite iglo, tako da jo držite pod enakim kotom in ohranjate pritisk na bat, nato pa spustite kožo.
English: The no observed adverse effect level for embryo-fetal toxicity in this study was 10 µg/kg/day, which corresponded to a systemic exposure of approximately 3-5 times the exposures observed in patients treated with the clinical dose.
Slovenian: V tej študiji je znašal odmerek brez opaznih negativnih vplivov za toksičnost zarodka oz. ploda 10 µg/kg/dan, kar ustreza sistemski izpostavljenosti, ki je približno 3- do 5-krat večja od izpostavljenosti, ki so jo zabeležili pri bolnikih, ki so prejemali klinični odmerek.
English: Put the needle fully into the skin as shown by your nurse or doctor (see picture 7).
Slovenian: Napolnjena injekcijska brizga z varnostno zaščito za iglo h. Zabodite iglo do konca v kožo, kot sta vam pokazala medicinska sestra ali zdravnik (glejte sliko 7).
English: Splenomegaly is a direct effect of treatment with filgrastim.
Slovenian: Neposredna posledica zdravljenja s filgrastimom je splenomegalija.
English: In a small number of patients (< 10%), doses up to 1.0 MU (10 µg) /kg/day were required to achieve reversal of neutropenia.
Slovenian: Pri majhnem številu bolnikov (< 10%) so bili za dosego odpravljene nevtropenije potrebni odmerki do 1,0 M e. (10 µg)kg/dan.
English: Offspring of rats administered filgrastim during the peri-natal and lactation periods, exhibited a delay in external differentiation and growth retardation (≥20 µg/kg/day) and slightly reduced survival rate (100
Slovenian: so zabeležili zaostanek pri zunanji diferenciaciji in zastoj v rasti (≥ 20 µg/kg/dan) ter nekoliko zmanjšano stopnjo preživetja (100 µg/kg/dan).
English: In view of the possible risk of microbial contamination, Accofil syringes are for single use only.
Slovenian: Ker obstaja tveganje mikrobne kontaminacije, so z zdravilom Accofil napolnjene brizge namenjene izključno enkratni uporabi.
English: • a pre-filled syringe of Accofil;
Slovenian: • napolnjeno injekcijsko brizgo z zdravilom Accofil,
English: Special precautions in patients undergoing PBPC mobilization
Slovenian: Posebni varnostni ukrepi za bolnike, pri katerih se izplavljajo PBPC
English: Keep the pre-filled syringe in the carton in order to protect from light.
Slovenian: Napolnjeno injekcijsko brizgo shranjujte v zunanji ovojnini za zagotovitev zaščite pred svetlobo.
English: Talk to your doctor, pharmacist or nurse before using Accofil:
Slovenian: Pred začetkom uporabe zdravila Accofil se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro:
English: In order to improve traceability of granulocyte-colony stimulating factors, the product name (Accofil) and batch number of the administered product should be clearly recorded in the patient file Accofil should not be diluted with sodium chloride solution.
Slovenian: Za izboljšanje sledljivosti granulocitne kolonije spodbujajočih faktorjev je treba ime zdravila (Accofil) in številko serije uporabljenega zdravila jasno zapisati v bolniško kartoteko.
English: This medicine is given by injection, either through an intravenous (IV) infusion (drip) or by a subcutaneous (SC) injection into the tissue just under the skin.
Slovenian: infuzije (kapalne infuzije) ali v tkivo tik pod kožo (s.c.) v obliki subkutane injekcije.
English: Transformation to leukaemia or myelodysplastic syndrome Special care should be taken in the diagnosis of SCNs to distinguish them from other haematopoietic disorders such as aplastic anaemia, myelodysplasia and myeloid leukaemia.
Slovenian: Posebna pozornost je potrebna pri diagnosticiranju hudih kroničnih nevtropenij, da bi jih lahko razlikovali od drugih motenj hematopoeze, kot na primer aplastične anemije, mielodisplazije in mieloične levkemije.
English: Please tell your doctor before starting treatment if you have:
Slovenian: Pred začetkom zdravljenja obvestite zdravnika:
English: Subsequently, the dose may be individually adjusted every 1-2 weeks to maintain the average neutrophil count between 1.5 x 109/L and 10 x 109/L.A faster schedule of dose escalation may be considered in patients presenting with severe infections.
Slovenian: Nato je mogoče odmerek individualno prilagajati na vsak(a) 1-2 tedna, da se ohrani povprečno število nevtrofilcev med 1,5 x 109/L in 10 x 109/L.
English: Accofil may have a minor influence on the ability to drive and use machines.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji Zdravilo Accofil lahko ima blag vpliv na sposobnost vožnje in upravljanja s stroji.
English: If you see blood in the syringe, remove the needle and re-insert it in another place.
Slovenian: potegnite iglo ven in jo ponovno vstavite na drugem mestu.
English: • If you have a combination of any of the following symptoms:
Slovenian: • če se pojavi kombinacija katerih koli naslednjih neželenih učinkov: povišana telesna temperatura,
English: Special precautions in normal donors undergoing peripheral blood progenitor cell mobilization
Slovenian: Posebni previdnostni ukrepi pri zdravih dajalcih pred alogensko presaditvijo v periferno kri izplavljenih matičnih celic
English: Abdominal palpation should be sufficient to detect abnormal increases in splenic volume.
Slovenian: Za odkritje nenormalnega povečanja vranice bi morala zadoščati palpacija trebuha.
English: Patients treated with myeloablative therapy followed by bone marrow transplantation Filgrastim is administered as an intravenous short-term infusion over 30 minutes or as a subcutaneous or intravenous continuous infusion over 24 hours, in each case after dilution in 20 ml of glucose 50 mg/ml (5%) solution.
Slovenian: Filgrastim se daje v obliki 30 minutne kratkotrajne intravenske infuzije ali v obliki 24-urne neprekinjene subkutane ali intravenske infuzije, v obeh primerih po razredčitvi v 20 ml raztopine 50 mg/ml (5%) glukoze.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na zdravilno učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1. 4.4 Posebna opozorila in previdnostni ukrepi Sledljivost
English: You should not receive Accofil in the 24 hours before and the 24 hours after receiving chemotherapy.
Slovenian: Zdravila Accofil ne smete prejeti 24 ur pred kemoterapijo in 24 ur po njej.
English: Depress the plunger slowly and evenly until the entire dose has been given and the plunger cannot be depressed any further.
Slovenian: Bat počasi in enakomerno pritisnite navzdol, dokler ni vbrizgan celotni odmerek in bata ni mogoče potisniti še naprej.
English: If you are a patient with severe chronic neutropenia, you may be at risk of developing cancer of the blood (leukaemia, myelodysplastic syndrome (MDS)) You should talk to your doctor about your risks of developing cancers of the blood and what testing should be done.
Slovenian: Če imate hudo kronično nevtropenijo, obstaja tveganje za razvoj raka krvi (levkemija, mielodisplastični sindrom (MDS)).
English: In the post-marketing setting cutaneous vasculitis has been reported in patients treated with filgrastim.
Slovenian: V obdobju trženja so pri bolnikih, zdravljenih s filgrastimom, poročali o kožnem vaskulitisu.
English: Therefore, filgrastim is not indicated for use in these conditions.
Slovenian: Zato filgrastim pri teh boleznih ni indiciran.
English: Filgrastim for PBPC mobilisation when used alone Filgrastim may be given as a 24 hour subcutaneous continuous infusion or subcutaneous injection.
Slovenian: Če se filgrastim uporablja za izplavljanje PBPC samostojno Filgrastim se lahko daje v obliki neprekinjene subkutane infuzije ali subkutane injekcije.
English: Call your doctor right away if you experience puffiness in your face or ankles, blood in your urine or brown-coloured urine or you notice you urinate less than usual
Slovenian: Če opazite zabuhlost obraza ali gležnjev, kri v urinu, rjavo obarvan urin ali če izločate manj urina kot običajno, o tem takoj obvestite zdravnika.
English: For the mobilisation of PBPCs in normal donors prior to allogeneic PBPC transplantation
Slovenian: Za izplavljanje PBPC pri zdravih dajalcih pred alogensko presaditvijo PBPC
English: It is quite normal to have a number of courses of treatment with Accofil.
Slovenian: Zdravljenje z zdravilom Accofil v večih ciklusih je povsem normalno.
English: Long-term treatment with Accofil is required for reduction in neutropenia.
Slovenian: Pri nevtropeniji je potrebno dolgotrajno zdravljenje z zdravilom Accofil.
English: The frequency is estimated as uncommon from clinical trial data.
Slovenian: Iz kliničnih podatkov se ocenjuje, da je pogostnost občasna.
English: Accofil may have a minor influence on your ability to drive and use machines.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Accofil lahko ima blag vpliv na vašo sposobnost upravljanja vozil in strojev.
English: Ensure the needle cover remains on the syringe until just before you are ready to inject.
Slovenian: Pokrovček lahko z injekcijske brizge snamete šele tik pred injiciranjem.
English: Filgrastim for PBPC mobilisation after myelosuppressive chemotherapy Filgrastim should be given by subcutaneous injection.
Slovenian: Če se filgrastim uporablja za izplavljanje PBPC po mielosupresivni kemoterapiji Filgrastim se daje v obliki subkutane injekcije.
English: • Sickle cell anaemia, accofil may cause sickle cell crisis.
Slovenian: • če imate srpastocelično anemijo (zdravilo Accofil lahko povzroči srpastocelično krizo);
English: Each pre-filled syringe contains 48 MU (equivalent to 480 micrograms of filgrastim in 0.5 ml solution for injection or infusion.
Slovenian: Ena napolnjena injekcijska brizga vsebuje 48 M e. (kar ustreza 480 mikrogramom) filgrastima v 0,5 ml raztopine za injiciranje ali infundiranje.
English: If you are donating stem cells for yourself, the usual dose is 0.5 million units (5 micrograms) to 1 million units (10 micrograms) per kilogram bodyweight each day.
Slovenian: Če matične celice darujete zase, je običajni odmerek 0,5 milijonov enot (5 mikrogramov) do 1 milijona enot (10 mikrogramov) na kilogram telesne mase vsak dan. Zdravljenje z zdravilom Accofil bo trajalo do 2 tedna.
English: How do I inject Accofil myself?
Slovenian: Kako si sami vbrizgate zdravilo Accofil?
English: Put the needle fully into the skin as shown by your nurse or doctor (see picture 6).
Slovenian: Napolnjena injekcijska brizga brez varnostne zaščite za iglo b. Zabodite iglo do konca v kožo, kot sta vam pokazala medicinska sestra ali zdravnik (glejte sliko 6).
English: • lungs do not function as they should, causing breathlessness (respiratory failure)
Slovenian: • težave s pljuči, kar povzroči zasoplost (dihalna odpoved)
English: • generalised weakness (asthenia)
Slovenian: • splošna šibkost (astenija)
English: Capillary leak syndrome has been reported after granulocyte colony-stimulating factor administration, and is characterised by hypotension, hypoalbuminaemia, oedema and hemoconcentration.
Slovenian: Zanj so značilni hipotenzija, hipoalbuminemija, edem in hemokoncentracija.
English: Each pre-filled syringe contains 30 MU (equivalent to 300 micrograms of filgrastim in 0.5 ml solution for injection or infusion.
Slovenian: Ena napolnjena injekcijska brizga vsebuje 30 M e. (kar ustreza 300 mikrogramom) filgrastima v 0,5 ml raztopine za injiciranje ali infundiranje.
English: However, during the period of administration of filgrastim for PBPC mobilisation, filgrastim should be discontinued or its dosage should be reduced if the leukocyte counts rise to > 70 x 109/L.
Slovenian: Če bolnik prejema filgrastim za izplavljanje PBPC, je treba z zdravljenjem s filgrastimom prenehati ali zmanjšati odmerek, če število levkocitov preseže vrednost > 70 x 109/L.
English: Transient thrombocytopenia (platelets < 100 x 109/L) following filgrastim administration and leukapheresis was observed in 35% of subjects studied.
Slovenian: Prehodno trombocitopenijo (število trombocitov < 100 x 109/L) so po dajanju filgrastima in levkaferezi ugotovili pri 35% preučevanih oseb.
English: • fever (pyrexia)
Slovenian: • povišana telesna temperatura (pireksija)
English: Long term treatment with Accofil may be required to maintain a normal number of white cells in your blood.
Slovenian: Morda bo za vzdrževanje normalnega števila belih krvničk v vaši krvi potrebno dolgoročno zdravljenje z zdravilom Accofil
English: In clinical studies, dosing with 30 MU (300 µg)/day on 1 - 7 days per week was required to maintain the ANC > 2.0 x 109/L, with the median dose frequency being 3 days per week.
Slovenian: V kliničnih študijah so morali za vzdrževanje absolutnega števila nevtrofilcev na ravni > 2,0 x 109/L uporabljati 30 M e. (300 µg)/dan v obdobju od enega do sedmih dni na teden; mediana pogostnosti dajanja je znašala 3 dni na teden.