FrancophonIA/ELRC3.0 huggingface dataset:
English: Vial (15 mL Type 1 glass) with a stopper (halobutyl-rubber) and flip off seal (aluminium).
Croatian: Bočica (15 ml, staklo tipa 1) s čepom (halobutilna guma) i zaštitnom "flip-off" kapicom i prstenom (aluminij)
English: In study VI, which only included adults, a significantly higher proportion of patients in the abatacept plus methotrexate group (41%) achieved DAS28 (CRP)-defined remission (score < 2.6) versus the methotrexate plus placebo group (23%) at year 1.
Croatian: U ispitivanju VI, u koje su uključeni samo odrasli bolesnici, nakon godinu dana liječenja je remisiju prema indeksu DAS28--CRP (rezultat < 2,6) postigao značajno veći udio bolesnika u skupini abatacept i metotreksat (41%) u usporedbi s bolesnicima u skupini metotreksat i placebo (23%).
English: - Insert the syringe needle into the vial through the centre of the rubber stopper and direct the stream of water for injections to the glass wall of the vial.
Croatian: - - Uvedite iglu u bočicu kroz sredinu gumenog čepa i usmjerite mlaz vode za injekcije na staklenu stijenku bočice.
English: Gather supplies for your injection on a clean, flat surface (only the ClickJect Pre-filled Pen is included in the package): Alcohol swab
Croatian: Položite pribor za injekciju na čistu i ravnu površinu (u pakiranje je uključena samo napunjena brizgalica ClickJect): vatu natopljena alkoholom flaster pamučnu vatu ili gazu napunjenu brizgalicu ClickJect spremnik za odlaganje oštrih predmeta
English: • Please make sure you also have a list of all your other medicines with you at any visit to a health care professional.
Croatian: • Prilikom svakog posjeta liječniku obavezno ponesite popis svih drugih lijekova koje uzimate.
English: In SC-I, the ACR 20 response rates at day 169 for subcutaneous and intravenous abatacept were respectively 78.3% (472/603 SC) and 76.0% (456/600 IV) in patients < 65 years, versus 61.1% (55/90 SC) and 74.4% (58/78 IV) for patients ≥ 65 years.
Croatian: U ispitivanju SC-I udio odgovora ACR20 169. dana iznosio je 78,3% (472/603) kod supkutane primjene i 76,0% (456/600) kod intravenske primjene u bolesnika mlađih od 65 godina, u odnosu na 61,1% (55/909) kod supkutane primjene te 74,4% (58/78) kod intravenske primjene u bolesnika u dobi od ≥ 65 godina.
English: In placebo-controlled clinical trials, in comparison with patients treated with TNFinhibitors and placebo, patients who received combination TNF-inhibitors with abatacept experienced an increase in overall infections and serious infections (see section 4.5).
Croatian: U placebom kontroliranim kliničkim ispitivanjima je u bolesnika liječenih kombinacijom TNF-inhibitora i abatacepta zabilježen porast broja ukupnih infekcija i ozbiljnih infekcija u usporedbi s bolesnicima koji su primali TNF-inhibitore i placebo (vidjeti dio 4.5).
English: B. Position the syringe and inject ORENCIA Hold the syringe by its body in one hand between your thumb and index finger (Figure 5).
Croatian: Držite štrcaljku za tijelo štrcaljke između palca i kažiprsta jedne ruke (Slika 5).
English: In pre-clinical embryo-fetal development studies no undesirable effects were observed at doses up to 29-fold a human 10 mg/kg dose based on AUC.
Croatian: U pretkliničkim istraživanjima embrio-fetalnog razvoja nisu zabilježene nuspojave pri dozama koje su, na temelju AUC-a, bile do 29 puta veće od doze za ljude od 10 mg/kg.
English: The abatacept + MTX group had less progression in structural damage compared with MTX group as reflected by mean treatment difference of the abatacept + MTX group versus MTX group (Table 6).
Croatian: + MTX zabilježena je manja progresija strukturnog oštećenja nego u skupini koja je primala samo MTX, što pokazuje srednja vrijednost razlike između liječenja abataceptom + MTX-om i liječenja samo MTX-om (Tablica 6).
English: Let your Pre-filled syringe warm up.
Croatian: Pričekajte da se napunjena štrcaljka ugrije.
English: • See the ORENCIA package leaflet for more information.
Croatian: • Za dodatne informacije pročitajte uputu o lijeku za lijek ORENCIA.
English: With your other hand, gently pinch the cleaned skin.
Croatian: Drugom rukom nježno uhvatite nabor očišćene kože.
English: ORENCIA is usually used in combination with methotrexate, although ORENCIA may also be used alone in case of intolerance to methotrexate or if treatment with methotrexate is inappropriate.
Croatian: ORENCIA se obično primjenjuje u kombinaciji s metotreksatom, ali može se koristiti i sama ako bolesnik ne podnosi metotreksat ili ako liječenje metotreksatom nije prikladno.
English: Injection Reactions in adult patients treated with subcutaneous abatacept
Croatian: Reakcije na injekcije u odraslih bolesnika liječenih abataceptom primijenjenim supkutano
English: After removing the pre-filled syringe from the refrigerator the pre-filled syringe should be allowed to reach room temperature by waiting 30 minutes, before injecting ORENCIA.
Croatian: Nakon što se napunjena brizgalica izvadi iz hladnjaka, treba pričekati 30 minuta da se napunjena brizgalica zagrije na sobnu temperaturu prije injiciranja lijeka ORENCIA.
English: 125 mg/mL orange plunger
Croatian: 125 mg/mL narančasti klip
English: One patient was diagnosed with multiple sclerosis while in the extension period of the pJIA IV study.
Croatian: U jednog je bolesnika tijekom razdoblja nastavka ispitivanja pJIA IV dijagnosticirana multipla skleroza.
English: Placebo +DMARDsb n = 133
Croatian: Placebo +DMARD-i b n = 133
English: Choose your injection site in either the abdomen or front of the thigh.
Croatian: Odaberite mjesto injekcije na trbuhu ili prednjem dijelu bedara.
English: Do not use this medicine if the liquid is cloudy or discoloured, or has large particles.
Croatian: Ovaj lijek se ne smije upotrijebiti ako je tekućina mutna ili je promijenila boju, ili sadrži velike čestice.
English: Abatacept has been studied in patients with pJIA in 2 clinical trials (ongoing pJIA SC study and pJIA IV study).
Croatian: Abatacept se ispitivao u bolesnika s pJIA-om u dvama kliničkim ispitivanjima (ispitivanje pJIA SC, koje je u tijeku, i ispitivanje pJIA IV).
English: Population pharmacokinetic analyses revealed that there was a trend toward higher clearance of abatacept with increasing body weight.
Croatian: Analize populacijske farmakokinetike otkrile su trend povećanja klirensa abatacepta s povećanjem tjelesne težine.
English: A randomised, single(investigator)-blinded, non-inferiority study was conducted to assess the safety and efficacy of weekly subcutaneous (SC) abatacept without an abatacept intravenous (IV) loading dose versus every-other-weekly subcutaneous adalimumab, both with background MTX, in patients with an inadequate response to methotrexate (study SC-II).
Croatian: Randomizirano, jednostruko (za ispitivača) slijepo ispitivanje neinferiornosti provedeno je s ciljem ocjenjivanja sigurnosti i djelotvornosti abatacepta primijenjenog supkutano (s.c.) jedanput na tjedan bez intravenske (i.v.) udarne doze abatacepta naspram adalimumaba primijenjenog supkutano jedanput svaka dva tjedna u bolesnika koji nisu dovoljno dobro odgovorili na metotreksat; oba lijeka primjenjivala su se uz osnovnu terapiju MTX-om (ispitivanje SC-II).
English: Among the patients who entered the open-label 12 month period, 59% (125/213) of patients receiving continuous abatacept plus methotrexate treatment and 48% (92/192) of patients who initially received methotrexate and switched to combination with abatacept had no progression.
Croatian: Među bolesnicima koji su ušli u otvoreno 12-mjesečno razdoblje ispitivanja, progresija nije nastupila u 59% (125/213) onih koji su kontinuirano liječeni abataceptom i metotreksatom te u 48% (92/192) bolesnika koji su najprije primali metotreksat i placebo pa su potom prebačeni na kombinaciju s abataceptom.
English: ORENCIA solution for injection in pre-filled pen has not been studied in children and adolescents under the age of 18 years.
Croatian: ORENCIA otopina za injekciju u napunjenoj brizgalici nije ispitivana u djece i adolescenata mlađih od 18 godina.
English: DAS28-CRP Remissione
Croatian: Remisija prema indeksu DAS28-CR
English: Dispose of used ClickJect Pre-filled Pen into sharps disposal container right away after use.
Croatian: Upotrijebljenu napunjenu brizgalicu ClickJect odložite u spremnik za odlaganje oštrih predmeta odmah nakon uporabe.
English: In addition, study V investigated the safety and efficacy of abatacept or infliximab relative to placebo.
Croatian: V ispitivale su se sigurnost i djelotvornost abatacepta ili infliksimaba u odnosu na placebo.
English: Common (may affect up to 1 in 10 people): upper airway infection (including infections of nose, sinus and throat) fever
Croatian: Često (mogu se javiti u do 1 na 10 osoba): infekcija gornjih dišnih putova (uključujući infekcije nosa, sinusa i grla) vrućica
English: PREPARE YOUR CLICKJECT PEN
Croatian: Upoznajte svoju napunjenu brizgalicu ClickJect
English: Of the 133 (70%) patients with no prior TNF-inhibitor therapy, 101 (76%) achieved at least an ACR Pedi 30 response; of the 57 patients who had received prior TNF-inhibitor therapy, 22 (39%) achieved at least an ACR Pedi 30 response.
Croatian: Od 133 (70%) bolesnika koji prethodno nisu bili na terapiji TNF-inhibitorima, 101 (76%) je postigao barem odgovor Ped ACR30.
English: ORENCIA solution for injection is injected under the skin (subcutaneous use).
Croatian: ORENCIA otopina za injekciju injicira se supkutano (potkožno).
English: Dispose the used pre-filled syringe into sharps disposal container right away after use.
Croatian: Upotrijebljenu štrcaljku odložite u spremnik za odlaganje oštrih predmeta odmah nakon uporabe.
English: Immunogenicity in patients with pJIA treated with subcutaneous abatacept
Croatian: Imunogenost u bolesnika s pJIA-om liječenih supkutanom formulacijom abatacepta
English: Before you are given ORENCIA, your doctor may examine you for hepatitis.
Croatian: Prije nego što primite lijek ORENCIA, liječnik će Vas možda testirati na hepatitis.
English: This medicinal product contains 0.014 mmol sodium (0.322 mg) per pre-filled pen, that is to say essentially ‘sodium- free'.
Croatian: Ovaj lijek sadrži 0,014 (0,322 mg) mmol natrija po napunjenoj brizgalici, tj.zanemarive količine natrija.
English: EU/1/07/389/007 1 pre-filled syringe with needle guard EU/1/07/389/008 4 pre-filled syringes with needle guard EU/1/07/389/010 3 pre-filled syringes with needle guard
Croatian: EU/1/07/389/007 1 napunjene štrcaljke sa štitnikom za iglu EU/1/07/389/008 4 napunjene štrcaljke sa štitnikom za iglu EU/1/07/389/010 3 napunjene štrcaljke sa štitnikom za iglu
English: Concomitant medication, such as methotrexate, corticosteroids, and NSAIDs, did not influence abatacept apparent clearance.
Croatian: Istodobno primijenjeni lijekovi, kao što su metotreksat, kortikosteroidi i NSAIL-i, nisu utjecali na prividni klirens abatacepta.
English: Study I patients were randomised to receive abatacept 2 or 10 mg/kg or placebo for 12 months.
Croatian: I bolesnici su randomizirani da tijekom 12 mjeseci primaju abatacept u dozi od 2 ili 10 mg/kg, odnosno placebo.
English: - Upon complete dissolution of the powder, the vial should be vented with a needle to dissipate any foam that may be present.
Croatian: - - Nakon potpunog otapanja praška, bočicu treba odzračiti iglom kako bi se odstranila eventualna pjena.
English: Sharps containers are special puncture-resistant disposal bins that can be bought at many retail outlets.
Croatian: To je posebna posuda koja se ne može probušiti i može se kupiti u mnogim trgovinama.
English: Non-responder in Period A
Croatian: Nisu odgovorili u Razdoblju
English: In placebo-controlled clinical trials with abatacept, adverse reactions (ARs) were reported in 49.4% of abatacept-treated patients and 45.8% of placebo-treated patients.
Croatian: U placebom kontroliranim kliničkim ispitivanjima abatacepta nuspojave su prijavljene u 49,4% bolesnika liječenih abataceptom i 45,8% bolesnika koji su primali placebo.
English: Don't use the syringe if it is dropped without the needle cover in place.
Croatian: Nemojte upotrijebiti štrcaljku ako je pala bez poklopca igle.
English: Boolean Clinical Remission Estimate of Difference (95% CI) vs. MTX
Croatian: Klinička remisija prema načelima Booleove algebre Procijenjena razlika (95% CI) u odnosu na MTX
English: C. Check the liquid in the syringe Hold the syringe by its body, with the covered needle pointing down.
Croatian: Provjerite tekućinu u štrcaljki Držite štrcaljku za tijelo štrcaljke, prekrivenom iglom okrenutom prema dolje.
English: If a patient misses an injection of abatacept and is within three days of the planned date, he/she should be instructed to take the missed dose immediately and remain on the original weekly schedule.
Croatian: Propusti li bolesnik injekciju abatacepta, a od planirane primjene nije prošlo više od 3 dana, treba mu/joj savjetovati da odmah primijeni propuštenu dozu te se dalje pridržava originalnog tjednog rasporeda doziranja.
English: During the 12-week pre-filled pen period of the substudy, there were no deaths or related SAEs.
Croatian: Tijekom 12-tjednog razdoblja podispitivanja u kojem se lijek primjenjivao napunjenom brizgalicom nije zabilježen nijedan smrtni slučaj niti ozbiljne nuspojave povezane s lijekom.
English: Complete ALL steps for full-dose delivery:
Croatian: Da biste primijenili cijelu dozu, prođite kroz SVE navedene korake:
English: ORENCIA 87.5 mg solution for injection in pre-filled syringe Each pre-filled syringe contains 87.5 mg of abatacept in 0.7 mL.
Croatian: ORENCIA 87,5 mg otopina za injekciju u napunjenoj štrcaljki Jedna napunjena štrcaljka sadrži 87,5 mg abatacepta u 0,7 ml.
English: The overall safety profile was comparable between studies PsA-I and PsA-II and consistent with the safety profile in rheumatoid arthritis (Table 1).
Croatian: PsA-I i PsA-II te je bio u skladu sa sigurnosnim profilom kod reumatoidnog artritisa (Tablica 1).
English: Not assessed a day 169 Last Observation Carried Forward (LOCF) for patients treated in Period C b As observed
Croatian: Nisu ocijenjeni a Za bolesnike liječene u Razdoblju C dalje su se prenosili rezultati zabilježeni 169. dana b Prema opaženome
English: During Period B, the time to disease flare for the patients randomised to placebo was significantly shorter than for those randomised to abatacept (primary endpoint, p=0.0002; log-rank test).
Croatian: Tijekom Razdoblja B, vrijeme do razbuktavanja bolesti u bolesnika randomiziranih za placebo bilo je značajno kraće nego u bolesnika randomiziranih za abatacept (primarna mjera ishoda, p = 0,0002; log-rang test).
English: ORENCIA contains sodium
Croatian: ORENCIA sadrži natrij
English: AFTER THE INJECTION
Croatian: SAMO kad injekciju daje
English: Similarly, the frequencies of serious infection and malignancy among subcutaneous abatacept-treated patients over age 65 were higher than among those under age 65.
Croatian: Slično tomu, učestalost ozbiljnih infekcija i zloćudnih bolesti kod supkutane primjene abatacepta bila je veća u bolesnika starijih od 65 godina, nego u onih mlađih od 65 godina.
English: Medicinal products that affect the immune system, including abatacept, may blunt the effectiveness of some immunisations (see section 4.5).
Croatian: Lijekovi koji djeluju na imunološki sustav, uključujući abatacept, mogu umanjiti učinkovitost nekih cijepljenja (vidjeti dio 4.5).
English: The abatacept + MTX group had less progression in structural damage compared with MTX group as reflected by mean treatment difference of the abatacept + MTX group versus MTX group (Table 5).
Croatian: + MTX zabilježena je manja progresija strukturnog oštećenja nego u skupini koja je primala samo MTX, što pokazuje srednja vrijednost razlike između liječenja abataceptom + MTX-om i liječenja samo MTX-om (Tablica 5).
English: Table 7:
Croatian: Tablica 7:
English: The overall safety profile was comparable between studies PsA-I and PsA-II and consistent with the safety profile in rheumatoid arthritis (Table 2).
Croatian: PsA-I i PsA-II te je bio u skladu sa sigurnosnim profilom kod reumatoidnog artritisa (Tablica 2).
English: It's normal to see a drop of fluid leaving the needle.
Croatian: Normalno je da iz igle izađe kapljica tekućine.
English: Upon complete dissolution of the powder, the vial should be vented with a needle to dissipate any foam that may be present.
Croatian: Nakon potpunog otapanja praška, bočicu treba odzračiti iglom kako bi se odstranila eventualna pjena.
English: Medicinal products that affect the immune system, including abatacept, may blunt the effectiveness of some immunisations (see sections 4.4 and
Croatian: Lijekovi koji djeluju na imunološki sustav, uključujući abatacept, mogu umanjiti učinkovitost nekih cijepljenja (vidjeti dijelove 4.4 i 4.6).
English: Clinical responses were maintained or continued to improve up to one year in studies PsA-I and PsA-II.
Croatian: Klinički odgovori održali su se ili su se nastavili poboljšavati do godinu dana u ispitivanjima
English: Preparation of infusion: immediately after reconstitution, dilute the concentrate to 100 mL with sodium chloride 9 mg/mL (0.9%) solution for injection.
Croatian: Priprema infuzije: odmah nakon pripreme, razrijedite koncentrat do volumena od 100 ml otopinom natrijevog klorida za injekciju od 9 mg/ml (0,9%).
English: Gently clean injection site with an alcohol swab and let your skin dry.
Croatian: Nježno očistite mjesto injekcije vatom natopljenom alkoholom i pričekajte da se koža osuši.
English: Steady state of abatacept was achieved by day 85 following the weekly body-weight-tiered subcutaneous abatacept dosing.
Croatian: Koncentracije abatacepta postigle su stanje dinamičke ravnoteže do 85. dana uz tjednu primjenu supkutanih doza abatacepta određenih na temelju tjelesne težine.
English: The primary outcome, incidence of AEs, SAEs, and discontinuations due to AEs during 6 months of treatment, was similar between those who were previous and current TNF-inhibitor users at enrollment, as was the frequency of serious infections.
Croatian: Primarna mjera ishoda: incidencija nuspojava, ozbiljnih nuspojava i prekida liječenja zbog nuspojava tijekom 6 mjeseci, bila je podjednaka u bolesnika koji su TNF-inhibitorima liječeni ranije i onih koji su uzimali TNF-inhibitore neposredno prije uključivanja u ispitivanje.Isto je vrijedilo i za učestalost ozbiljnih infekcija.
English: Check the pre-filled syringe for damage.
Croatian: Provjerite je li napunjena štrcaljka oštećena.
English: Do not use the pre-filled syringe if it is dropped after the needle cover is removed.
Croatian: Nemojte upotrijebiti napunjenu štrcaljku ako Vam padne nakon što skinete poklopac igle.
English: † p < 0.01, abatacept plus MTX vs. MTX plus placebo ‡ p < 0.001, abatacept plus MTX vs. MTX plus placebo †† p < 0.05, abatacept plus MTX vs. MTX plus placebo a Fixed dose approximating 10 mg/kg (see section 4.2).
Croatian: *** p < 0,001, abatacept naspram placeba. † p < 0,01, abatacept i MTX naspram MTX i placebo ‡ p < 0,001, abatacept i MTX naspram MTX i placebo †† p < 0,05, abatacept i MTX naspram MTX i placebo a Fiksna doza od približno 10 mg/kg (vidjeti dio 4.2).
English: There have been reports of tuberculosis in patients receiving ORENCIA (see section 4.8).
Croatian: U bolesnika koji su primali lijek ORENCIA prijavljeni su slučajevi tuberkuloze (vidjeti dio 4.8).
English: The incidence rates for malignancies was 1.3 (0.9, 1.9) per 100 patient-years for abatacept-treated patients and 1.1 (0.6, 1.9) per 100 patient-years for placebo-treated patients.
Croatian: Stopa incidencije zloćudnih bolesti iznosila je 1,3 (0,9; 1,9) na 100 bolesnik-godina u bolesnika liječenih abataceptom te 1,1 (0,6; 1,9) na 100 bolesnik-godina u bolesnika koji su primali placebo.
English: In study SC-III, abatacept subcutaneous was evaluated in combination with methotrexate (MTX), or as abatacept monotherapy, and compared to MTX monotherapy in induction of remission following 12 months of treatment, and the possible maintenance of drug-free remission after complete drug withdrawal, in adult MTX-naive patients with highly active early, rheumatoid arthritis (mean DAS28-CRP of 5.4; mean symptom duration less than 6.7 months) with poor prognostic factors for rapidly progressive disease (e.g., anti-citrullinated protein antibodies [ACPA+], as measured by antiCCP2 assay, and/or RF+, baseline joint erosions).
Croatian: U ispitivanju SC-III ocjenjivao se abatacept za supkutanu primjenu u kombinaciji s metotreksatom (MTX) ili u monoterapiji u usporedbi s monoterapijom MTX-om s obzirom na indukciju remisije nakon 12 mjeseci liječenja te moguće održavanje remisije bez liječenja nakon potpunog prekida terapije u odraslih bolesnika s izrazito aktivnim ranim oblikom reumatoidnog artritisa (srednja vrijednost indeksa DAS28-CRP: 5,4; srednja vrijednost trajanja simptoma: manje od 6,7 mjeseci) koji prethodno nisu bili liječeni MTX-om i koji su imali loše prognostičke faktore za brzo progredirajuću bolest (npr. antitijela na citrulinirane proteine [engl. anti-citrullinated protein antibodies, ACPA+], koja su se određivala anti-CCP2 testom, i/ili pozitivan nalaz RF-a, erozije zglobova na početku ispitivanja).
English: Unless they had discontinued due to safety reasons, all patients who completed, or had a flare during Period B or were non-responders in Period A were offered entry into Period C, the open-label extension, which assessed long-term safety and efficacy.
Croatian: Ako nisu prekinuli liječenje zbog sigurnosnih razloga, svim bolesnicima koji su završili Razdoblje B ili im se tijekom tog razdoblja bolest razbuktala te onima koji nisu odgovorili na liječenje u Razdoblju
English:  Supplies checklist: alcohol swabs, cotton ball or gauze, adhesive plaster, Sharps container.
Croatian:  Popis dodatnog pribora: vata natopljena alkoholom, pamučna vata ili gaza, flaster,
English: Higher ACR 20 responses were observed with abatacept vs placebo regardless of prior TNF-inhibitor treatment in both studies.
Croatian: U oba su ispitivanja opažene više stope odgovora ACR 20 uz abatacept nego uz placebo neovisno o prethodnom liječenju TNF-inhibitorima.
English: ORENCIA is available in packs of 1 vial and 1 silicone-free syringe, and in multipacks containing 2, or 3 vials and 2, or 3 silicone-free syringes (2 or 3 packs of 1).
Croatian: ORENCIA je dostupna u pakiranjima od 1 bočice i 1 nesilikonske štrcaljke i u višestrukim pakiranjima koja sadrže 2, odnosno 3 bočice i 2, odnosno 3 nesilikonske štrcaljke (2 ili 3 pakiranja po 1).
English: Wipe the injection site with an alcohol swab and let your skin dry.
Croatian: Obrišite mjesto injekcije vatom natopljenom alkoholom i pričekajte da se koža osuši.
English: Concomitant MTX, NSAIDs, corticosteroids, and TNF-inhibitors did not influence abatacept apparent clearance.
Croatian: Istodobno primijenjeni MTX, NSAIL-i, kortikosteroidi i TNF-inhibitori ne utječu na prividan klirens abatacepta.
English: 125 mg/mL Pre-filled Syringe
Croatian: 125 mg/mL Napunjena štrcaljka
English: Care of injection site:
Croatian: Njega mjesta injekcije:
English: If a patient misses an injection of ORENCIA and is within three days of the planned date, he/she should be instructed to take the missed dose immediately and remain on the original weekly schedule.
Croatian: Propusti li bolesnik injekciju lijeka ORENCIA, a od planirane primjene nije prošlo više od 3 dana, treba mu/joj savjetovati da odmah primijeni propuštenu dozu te se dalje pridržava originalnog tjednog rasporeda doziranja.
English: During the initial double blind 6 months period (short term period), the overall immunogenicity frequency to abatacept was 1.1% (8/725) and 2.3% (16/710)for the subcutaneous and intravenous groups, respectively.
Croatian: Tijekom početnog dvostruko slijepog 6-mjesečnog razdoblja (kratkotrajno razdoblje) ukupna učestalost imunogenosti na abatacept iznosila je 1,1% (8/725) u skupini u kojoj je primijenjen supkutano te 2,3% (16/710) u skupini u kojoj je primijenjen intravenski.
English: B. Prepare your injection site Wipe your injection site with an alcohol swab in a circular motion.
Croatian: Pripremite mjesto injekcije Kružnim pokretom obrišite mjesto injekcije vatom natopljenom alkoholom.