FrancophonIA/ELRC3.0 huggingface dataset:
English: A variable but limited decrease in red blood cell-related parameters was observed, together with increases in activated partial thromboplastin time.
Slovenian: Opazili so tudi spremenljivo, a omejeno zmanjšanje vrednosti eritrocitnih parametrov, skupaj s podaljšanjem aktiviranega parcialnega tromboplastinskega časa.
English: Darunavir is an inhibitor of the dimerisation and of the catalytic activity of the HIV-1 protease (KD of 4.5 x 10
Slovenian: Darunavir je zaviralec dimerizacije in katalitične aktivnosti proteaze HIV-1 (KD 4,5 x
English: R(-) methadone AUC ↓ 16% R(-) methadone Cmin ↓ 15% R(-) methadone Cmax ↓ 24%
Slovenian: R(-) metadon AUC ↓ 16 % R(-) metadon Cmin ↓ 15 % R(-) metadon Cmax ↓ 24 %
English: The doctor will inform you on how many Darunavir Krka tablets and how much ritonavir (capsules, tablets or solution) the child must take.
Slovenian: Zdravnik vam bo povedal, koliko tablet zdravila Darunavir Krka in koliko ritonavirja (kapsule, tablete ali raztopina) mora otrok zaužiti.
English: Voriconazole should only be taken after medical evaluation.
Slovenian: Vorikonazol se lahko uporablja samo po oceni zdravnika.
English: The substantial reduction in darunavir exposure may result in virological failure and an increased risk of mother to child transmission of HIV infection.
Slovenian: Precejšnje zmanjšanje izpostavljenosti darunavirju je lahko vzrok za virološki neuspeh in poveča tveganje za prenos okužbe z virusom HIV z matere na otroka.
English: Unlike ritonavir, cobicistat does not induce CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or UGT1A1.
Slovenian: Za razliko od ritonavirja kobicistat ne inducira CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 in UGT1A1.
English: Tell your doctor immediately if you notice any symptoms of infection (for example enlarged lymph nodes and fever).
Slovenian: - Nemudoma povejte svojemu zdravniku, če opazite kakršnekoli simptome okužbe (npr. zvečane bezgavke ali zvišano telesno temperaturo).
English: The unbound fraction was also substantially reduced, including around 90% reductions of Cmin levels.
Slovenian: Bistveno manj je bilo tudi nevezane frakcije, vključno s znižanjem Cmin.za približno 90%.
English: Psychiatric disorders common abnormal dreams
Slovenian: Psihiatrične motnje pogosti nenavadne sanje
English: Unlike ritonavir, cobicistat does not have inducing effects on enzymes or transport proteins (see section 4.5).
Slovenian: - Za razliko od ritonavirja, kobicistat nima indukcijskega učinka na encime ali transportne beljakovine (glejte poglavje 4.5).
English: The increased exposure was likely at least partly due to immaturity of the drug-metabolising enzymes in juvenile animals.
Slovenian: Zvečana izpostavljenost je bila vsaj deloma verjetno posledica nerazvitosti encimov za presnovo zdravila pri mladih podganah.
English: Nervous system disorders very common headache
Slovenian: Bolezni živčevja zelo pogosti glavobol
English: Total number of virologic failures a, n (%)
Slovenian: Celokupno število viroloških odpovedi a, n (%)
English: The digoxin dose should be carefully titrated to obtain the desired clinical effect while assessing the overall clinical state of the subject.
Slovenian: Odmerek digoksina je treba previdno titrirati do želenega kliničnega učinka in pri tem spremljati celoten klinični status bolnika.
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Slovenian: Če opazite kakršnekoli simptome okužbe ali druge simptome, na primer mišično oslabelost, oslabelost, ki se najprej pojavi v dlaneh in stopalih in nato širi proti trupu, palpitacije, tremor ali hiperaktivnost, nemudoma obvestite zdravnika, da boste prejeli potrebno zdravljenje.
English: Your child's doctor will determine the appropriate dosing regimen for your child.
Slovenian: Otrokov zdravnik bo določil najprimernejši odmerek za vašega otroka.
English: There are some medicines that you must not combine with Darunavir Krka.
Slovenian: Obstajajo določena zdravila, ki jih ne smete kombinirati z zdravilom Darunavir Krka.
English: Your doctor will determine whether Darunavir Krka tablets is right for the child.
Slovenian: Zdravnik bo določil, ali so tablete zdravila Darunavir Krka primerne za otroka.
English: Darunavir Krka with food and drink See section 3 ‘How to take Darunavir Krka.'
Slovenian: Zdravilo Darunavir Krka skupaj s hrano in pijačo Glejte poglavje 3 "Kako jemati zdravilo Darunavir Krka".
English: Clonazepam
Slovenian: klonazepam
English: People taking Darunavir Krka may still develop infections or other illnesses associated with HIV infection.
Slovenian: Pri osebah, ki jemljejo zdravilo Darunavir Krka, se lahko še vedno pojavijo okužbe ali druge bolezni, ki so povezane z okužbo s HIV.
English: According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended.
Slovenian: Skladno s trenutno veljavnimi smernicami, sočasno zdravljenje z dvema zaviralcema proteaz večinoma ni priporočljivo.
English: (MATE1 inhibition)
Slovenian: (zaviranje MATE1)
English: * DRV-RAMs: V11I, V32I, L33F, I47V, I50V, I54M, I54L, T74P, L76V, I84V and L89V
Slovenian: * DRV-RAM: V11I, V32I, L33F, I47V, I50V, I54M, I54L, T74P, L76V, I84V in L89V.
English: Dose adjustment for midazolam should be considered, especially if more than a single dose of midazolam is administered.
Slovenian: Razmisliti je treba o prilagoditvi odmerka midazolama, zlasti če mora bolnik prejeti več kot en odmerek midazolama.
English: Increased concentrations of quetiapine may lead to coma (see section 4.3).
Slovenian: Zvišana koncentracija kvetiapina lahko povzroči komo (glejte poglavje 4.3).
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections and pneumonia caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii).
Slovenian: Sem sodijo citomegalovirusni retinitis, generalizirane in/ali fokalne mikobakterijske okužbe in pljučnica, ki jo povzroča Pneumocystis jirovecii (prej znana kot Pneumocystis carinii).
English: These effects may be secondary to pup exposure to the active substance via the milk and/or maternal toxicity.
Slovenian: Ti učinki so lahko posledica izpostavljenosti učinkovini preko mleka in/ali toksičnosti za samico.
English: Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Slovenian: Znaki osteonekroze so okorelost sklepov, bolečine (še posebno v kolku, kolenu ali rami) in težave pri gibanju.
English: In the dog, no major toxicity findings or target organs were identified up to exposures equivalent to clinical exposure at the recommended dose.
Slovenian: Pri psih niso opazili večjih znakov toksičnosti ali opredelili ključnih tarčnih organov pri izpostavljenostih, ki ustrezajo klinični izpostavljenosti pri priporočenem odmerku.
English: Tablet dimension: 17 x 8.5 mm.
Slovenian: Velikost tablet: 17 x 8,5 mm.
English: It is therefore important to talk to your doctor if you develop a rash.
Slovenian: Zato je pomembno, da se pogovorite z zdravnikom, če se pri vas pojavi izpuščaj.
English: For ART-experienced paediatric patients HIV genotypic testing is recommended.
Slovenian: Pri pediatričnih bolnikih, ki že imajo izkušnje z ART, se priporoča testiranje genotipa HIV.
English: 6/l (see section 4.2).
Slovenian: 6/l (glejte poglavje 4.2).
English: ║ based on published data with darunavir/ritonavir rosuvastatin AUC ↑ 93% rosuvastatin Cmax ↑ 277% rosuvastatin Cmin ND
Slovenian: ║ na osnovi objavljenih podatkov s kombinacijo darunavir/ritonavir rosuvastatin AUC ↑ 93% rosuvastatin Cmax ↑ 277% rosuvastatin Cmin ND
English: Cobicistat levels decrease and may not provide sufficient boosting.
Slovenian: Koncentracija kobicistata je nižja in obstaja možnost, da ne zagotavlja zadostne okrepitve.
English: In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Slovenian: Pri nekaterih bolnikih z napredovalo okužbo s HIV in oportunističnimi okužbami v preteklosti se lahko kmalu po začetku zdravljenja okužbe z virusom HIV pojavijo znaki in simptomi predhodnih okužb.
English: For the treatment of pulmonary arterial hypertension Sildenafil
Slovenian: Za zdravljenje pljučne arterijske hipertenzije sildenafil tadalafil
English: Rifabutin 150 mg once every other day rifabutin AUC rifabutin Cmin
Slovenian: rifabutin 150 mg enkrat vsak drugi dan rifabutin AUC rifabutin Cmin
English: If you forget to take Darunavir Krka If you notice within 6 hours, you must take your missed dose immediately.
Slovenian: Če ste pozabili vzeti zdravilo Darunavir Krka Če to opazite v 6 urah, morate izpuščeni odmerek vzeti takoj.
English: What Darunavir Krka is and what it is used for What you need to know before you take Darunavir Krka How to take Darunavir Krka Possible side effects
Slovenian: Kaj je zdravilo Darunavir Krka in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Darunavir Krka Kako jemati zdravilo Darunavir Krka Možni neželeni učinki
English: INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS Medicinal products by therapeutic areas
Slovenian: MEDSEBOJNA DELOVANJA Z DRUGIMI ZDRAVILI IN PRIPOROČILA ZA ODMERJANJE Zdravila po terapevtskih področjih
English: In a pre- and postnatal development assessment in rats, darunavir with and without ritonavir, caused a transient reduction in body weight gain of the offspring pre-weaning and there was a slight delay in the opening of eyes and ears.
Slovenian: Pri pred in postnatalnem ovrednotenju razvoja pri podganah je darunavir z ali brez ritonavirja povzročil prehodno zmanjšanje telesne mase mladičev pred dojenjem, prisotna je bila tudi majhna zakasnitev pri odpiranju oči in ušes.
English: In the virologic failures of the GS-US-216-130 trial no cross-resistance with other HIV PIs was observed.
Slovenian: V preskušanju GS-US-216-130 pri primerih virološkega neuspeha zdravljenja niso opažali navzkrižne odpornosti proti drugim zaviralcem proteaz HIV.
English: Renal impairment Results from a mass balance study with
Slovenian: Okvara ledvic Izsledki preskušanja masnega ravnovesja z uporabo s
English: 100 milligram more than 40 kilograms
Slovenian: 100 mg več kot 40 kg
English: If you take more Darunavir Krka than you should Contact your doctor, pharmacist or nurse immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Darunavir Krka, kot bi smeli Nemudoma pokličite svojega zdravnika, farmacevta ali medicinsko sestro.
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis B or C, have an increased risk for liver function abnormalities including severe and potentially fatal hepatic adverse reactions.
Slovenian: Pri bolnikih z obstoječimi boleznimi jeter, vključno z aktivnim kroničnim hepatitisom B ali C, je tveganje za motnje delovanja jeter, vključno z resnimi in potencialno smrtnimi jetrnimi neželenimi učinki zvečano.
English: Based on pharmacokinetic modeling, this dosage reduction of 75% is also applicable if patients receive rifabutin at doses other than 300 mg/day.
Slovenian: Na osnovi podatkov, pridobljenih s farmakokinetičnim modeliranjem, je 75 % zmanjšanje odmerka priporočljivo tudi, če bolniki prejemajo rifabutin v odmerkih različnih od 300 mg/dan.
English: Severe hepatic impairment could result in an increase of darunavir exposure and a worsening of its safety profile.
Slovenian: Pri hudi okvari jeter se lahko izpostavljenost darunavirju zveča in poslabša njegov varnostni profil.
English: Always take with ritonavir and food.
Slovenian: Zdravilo vedno jemljite z ritonavirjem in s hrano.
English: How to store Darunavir Krka Contents of the pack and other information
Slovenian: Shranjevanje zdravila Darunavir Krka Vsebina pakiranja in dodatne informacije
English: Ciclosporin Sirolimus Tacrolimus Everolimus
Slovenian: IMUNOSUPRESIVI ciklosporin sirolimus tacrolimus everolimus
English: Your doctor should do blood tests before you start Darunavir Krka.
Slovenian: Zdravnik bo opravil krvne preiskave, preden začnete jemati zdravilo Darunavir Krka.
English: Limited efficacy data are available in paediatric patients below 15 kg and no recommendation on a posology can be made.
Slovenian: Podatki o učinkovitosti pri pediatričnih bolnikih s telesno maso, manjšo od 15 kg, so omejeni, zato pri njih ne moremo podati priporočil za odmerjanje.
English: The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort.
Slovenian: Učinek indukcije encimov je lahko prisoten še vsaj 2 tedna po prekinitvi zdravljenja s šentjanževko.
English: KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia TAD Pharma GmbH, Heinz-Lohmann-Straβe 5, 27472 Cuxhaven, Germany
Slovenian: KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenija TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Nemčija
English: The decreased susceptibility to darunavir of the emerging viruses in the selection experiment could not be explained by the emergence of these protease mutations.
Slovenian: Zmanjšano občutljivost novih virusov za darunavir v izbranem poskusu ni mogoče pojasniti z razvojem proteaznih mutacij.
English: Interactions between darunavir/ritonavir and antiretroviral and non-antiretroviral medicinal products are listed in the table below.
Slovenian: Interakcije med kombinacijo zdravil darunavir/ritonavir in drugimi protiretrovirusnimi in ne-protiretrovirusnimi zdravili so navedene v spodnji preglednici.
English: Several of the interaction studies have been performed with darunavir at lower than recommended doses.
Slovenian: Izvedli so več interakcijskih študij z odmerki darunavirja, manjšimi od priporočenih.
English: At the highest tested doses, the systemic exposures (based on AUC) to darunavir were between 0.4- and 0.7-fold (mice) and 0.7- and 1-fold (rats), relative to those observed in humans at the recommended therapeutic doses.
Slovenian: Pri najvišjih preskušanih odmerkih so bile vrednosti sistemske izpostavljenosti darunavirju (na osnovi AUC) med 0,4-in 0,7-kratne (pri miših) ter 0,7 in 1-kratne (pri podganah) glede na vrednosti, opažene pri ljudeh pri priporočenih terapevtskih odmerkih.
English: Data on comparison with a 150 mg once daily reference dose is lacking.
Slovenian: Podatkov o primerjavi z referenčnim odmerkom 150 mg enkrat na dan ni.
English: Your doctor will advise you how to deal with your symptoms or whether Darunavir Krka must be stopped.
Slovenian: Zdravnik vam bo povedal, kako glede na vaše simptome ravnati in ali je treba prekiniti zdravljenje z zdravilom Darunavir Krka.
English: However, unbound darunavir concentrations were approximately 55% (Child-Pugh Class A) and 100% (ChildPugh Class B) higher, respectively.
Slovenian: Koncentracije nevezanega darunavirja pa so bile približno 55 % (razred A po Child-Pughovi lestvici) in 100 % (razred B po Child-Pughovi lestvici) višje.
English: The rashes observed in clinical studies were mild to moderate in severity and did not result in discontinuation of therapy (see section 4.4).
Slovenian: Izpuščaji, ki so se pojavljali v kliničnih preskušanjih so bili blagi do zmerni in niso vodili v prekinitev zdravljenja (glejte poglavje 4.4).
English: Darunavir/ritonavir should not be used in children with a body weight of less than 15 kg as the dose for this population has not been established in a sufficient number of patients (see section 5.1).
Slovenian: Zdravili darunavir/ritonavir se ne smeta uporabljati pri otrocih s telesno maso, manjšo od 15 kg, ker odmerjanja pri tej populaciji ni bilo mogoče določiti pri zadostnem številu bolnikov (glejte poglavje 5.1).
English: For the treatment of HIV-1 infection in paediatric patients from the age of 3 years and at least 15 kg body weight.
Slovenian: - za zdravljenje okužbe z virusom HIV-1 pri pediatričnih bolnikih, starih najmanj 3 leta in s telesno maso najmanj 15 kg.
English: The table below shows the efficacy data of the 48-week and 96-week analyses from the pooled POWER 1 and POWER 2 trials.
Slovenian: Spodnja preglednica kaže podatke analize o učinkovitosti po 48 tednih in 96 tednih iz zbranih izsledkov preskušanj POWER 1 in POWER 2.
English: Apixaban, edoxaban, rivaroxaban, warfarin (to reduce clotting of the blood) as their therapeutic effect or side effects may be altered; your doctor may have to check your blood.
Slovenian: - apiksaban, edoksaban, rivaroksaban, varfarin(za zmanjšanje strjevanja krvi), ker se lahko spremenijo terapevtski ali neželeni učinki teh zdravil; zdravnik bo morda moral preverjati vašo kri.
English: Changes were observed in liver (hepatocyte hypertrophy, vacuolation, increased liver enzymes) and thyroid (follicular hypertrophy).
Slovenian: Spremembe so opazili v jetrih (hipertrofija hepatocitov, vakuolizacija, zvečanje koncentracij jetrnih encimov) in ščitnici (folikularna hipertrofija).
English: Therefore, no special precautions or dose adjustments are required in these patients (see sections 4.2 and 5.2).
Slovenian: Zato pri teh bolnikih posebna opozorila ali prilagoditve odmerka niso potrebna (glejte poglavji 4.2 in 5.2).
English: Elimination After a 400/100 mg
Slovenian: Izločanje Po 400/100 mg odmerku s
English: Patients with severe (Child-Pugh Class C) hepatic impairment.
Slovenian: Bolniki s hudo okvaro jeter (razred C po Child-Pughovi lestvici).
English: In repeated-dose toxicology studies in mice, rats and dogs, there were only limited effects of treatment with darunavir.
Slovenian: V študijah toksičnosti pri ponavljajočih se odmerkih na miših, podganah in psih so bili učinki zdravljenja z darunavirjem omejeni.
English: If prescribed Darunavir Krka twice daily the child must take one dose in the morning, and one dose in the evening.
Slovenian: Če se otroku predpiše zdravilo Darunavir Krka dvakrat na dan, mora vzeti en odmerek zjutraj in enega zvečer.
English: Furthermore, AUC of the sum of active moieties of rifabutin (parent drug + 25-Odesacetyl metabolite) was increased 1.6fold, while Cmax remained comparable.
Slovenian: Tudi AUC vsote aktivnih frakcij rifabutina (učinkovina + 25-Odeacetil presnovek) je bila zvečana 1,6-krat, Cmax pa je ostala primerljiva.
English: In a single arm trial investigating darunavir 800 mg once daily in combination with cobicistat 150 mg once daily and other antiretrovirals 2.2% of patients discontinued treatment due to rash.
Slovenian: V študiji z eno samo skupino preiskovancev, v kateri so preskušali 800 mg darunavirja enkrat na dan v kombinaciji s 150 mg kobicistata enkrat na dan in z drugimi protiretrovirusnimi zdravili, je 2,2 % bolnikov prekinilo zdravljenje zaradi izpuščaja.
English: The doctor will determine if once daily dosing or twice daily dosing is appropriate for the child.
Slovenian: Zdravnik bo določil, ali je za vašega otroka primernejše odmerjanje enkrat na dan ali odmerjanje dvakrat na dan.
English: At present the effect of raltegravir on darunavir plasma concentrations does not appear to be clinically relevant.
Slovenian: Zaenkrat ne kaže, da bi bil učinek raltegravirja na plazemske koncentracije darunavirja klinično pomemben.
English: After 2 years administration of darunavir at exposures at or below the human exposure, kidney changes were observed in mice (nephrosis) and rats (chronic progressive nephropathy).
Slovenian: Po 2 letih dajanja darunavirja so, pri izpostavljenostih enakih ali nižjih kot pri ljudeh, opazili spremembe na ledvicah pri miših (nefroze) in podganah (kronična progresivna nefropatija).
English: (Rifabutin is an inducer and substrate of CYP3A.)
Slovenian: (Rifabutin je induktor in substrat encimov CYP3A.)
English: There have been reports of increased spontaneous bleeding in haemophiliac patients receiving antiretroviral protease inhibitors (see section 4.4).
Slovenian: Obstajajo poročila o zvečanju spontanih krvavitev pri bolnikih s hemofilijo, ki prejemajo zaviralce retrovirusnih proteaz (glejte poglavje 4.4).
English: Haemophiliac patients should, therefore, be made aware of the possibility of increased bleeding.
Slovenian: Bolniki s hemofilijo se morajo zavedati možnosti zvečanih krvavitev.
English: Strong CYP3A inducers include e.g. carbamazepine, phenobarbital and phenytoin (see sections 4.4 and 4.5).
Slovenian: Močni induktorji CYP3A vključujejo npr. karbamazepin, fenobarbital in fenitoin (glejte poglavji 4.4 in 4.5).
English: Co-administration with CYP3Ametabolised corticosteroids is not recommended unless the potential benefit to the patient outweighs the risk, in which case patients should be monitored for systemic corticosteroid effects.
Slovenian: Sočasna uporaba s kortikosteroidi, ki se presnavljajo s CYP3A, ni priporočljiva, razen če morebitna korist zdravljenja odtehta tveganje, bolnike pa je treba spremljati glede sistemskih kortikosteroidnih učinkov.
English: Therefore, concomitant treatment with such medicinal products for which elevated plasma concentrations are associated with serious and/or life-threatening events is contraindicated (applies to darunavir boosted with either ritonavir or cobicistat).
Slovenian: Zato je sočasna uporaba zdravil, pri katerih so zvišane plazemske koncentracije povezane z resnimi in/ali življenjsko nevarnimi dogodki, kontraindicirana (velja za darunavir, okrepljen z ritonavirjem ali s kobicistatom).
English: The efficacy and safety of the use of darunavir with 100 mg ritonavir and any other HIV PI (e.g. (fos)amprenavir, nelfinavir and tipranavir) has not been established in HIV patients.
Slovenian: Učinkovitost in varnost sočasne uporabe darunavirja skupaj s 100 mg ritonavirja in z drugimi zaviralci proteaz HIV (npr. (fos)amprenavir, nelfinavir in tipranavir) pri bolnikih okuženih s HIV nista bili ugotovljeni.
English: There are currently inadequate data to determine whether co-administration of tenofovir disoproxil and cobicistat is associated with a greater risk of renal adverse reactions compared with regimens that include tenofovir disoproxil without cobicistat.
Slovenian: Zaenkrat ni na voljo zadosti podatkov, da bi lahko ugotovili, ali je sočasna uporaba dizoproksiltenofovirata in kobicistata povezana z večjim tveganjem za ledvične neželene učinke kot režimi, ki vključujejo dizoproksiltenofovirat brez kobicistata.
English: The exposure-adjusted rates of rash (all causality) were 10.9, 4.2, and 3.8 per 100 patient-years (PYR), respectively; and for drug-related rash were 2.4, 1.1, and 2.3 per 100 PYR, respectively.
Slovenian: Stopnje izpostavljenosti izpuščaju (vse vzročnosti) so bile 10,9; 4,2 in 3,8 na 100 bolnikov let oziroma 2,4; 1,1 in 2,3 na 100 bolnikov let pri izpuščaju, povezanem z zdravilom.
English: The absolute oral bioavailability of a single 600 mg dose of darunavir alone was approximately 37% and increased to approximately 82% in the presence of 100 mg twice daily ritonavir.
Slovenian: Absolutna peroralna biološka uporabnost enkratnega 600 mg odmerka samega darunavirja je bila približno 37 % in se je zvečala na približno 82 % v prisotnosti ritonavirja v odmerku 100 mg dvakrat na dan.
English: Fluticasone: in a clinical study where ritonavir 100 mg capsules twice daily were co-administered with 50 μg intranasal fluticasone propionate (4 times daily) for 7 days in healthy subjects, fluticasone propionate plasma concentrations increased significantly, whereas the intrinsic cortisol levels decreased by approximately 86% (90% CI 82-89%).
Slovenian: Flutikazon: v klinični študiji, v kateri so pri zdravih prostovoljcih 7 dni sočasno uporabljali 100 mg ritonavirja v kapsulah dvakrat na dan s 50 µg flutikazonpropionata (štirikrat na dan intranazalno), so se plazemske koncentracije flutikazona pomembno zvečale, medtem ko so se intrinzične koncentracije kortizola zmanjšale za približno 86 % (90 % interval zaupanja 82 %-89 %).
English: Infections and infestations uncommon herpes simplex
Slovenian: Infekcijske in parazitske bolezni občasni herpes simplex