FrancophonIA/ELRC3.0 huggingface dataset:
English: The concomitant use of CYP3A4 inhibitors and DUROGESIC is not recommended, unless the patient is closely monitored (see section 4.4).
Croatian: Ne preporučuje se istodobna primjena inhibitora CYP3A4 i lijeka DUROGESIC, osim u slučajevima kada se bolesnika pažljivo nadzire (vidjeti dio 4.4).
English: If you switch from a different painkiller to DUROGESIC or if you suddenly stop using DUROGESIC, you may notice withdrawal effects such as sickness, feeling sick, diarrhoea, anxiety or shivering.
Croatian: Ako prijeđete s drugog lijeka protiv boli na DUROGESIC ili ako naglo prestanete primjenjivati DUROGESIC, možda ćete primijetiti simptome ustezanja kao što su povraćanje, mučnina, proljev, tjeskoba ili drhtanje.
English: The resultant prolongation in gastrointestinal transit time may be responsible for the constipating effect of fentanyl.
Croatian: Posljedica toga je produljenje vremena prolaska kroz probavni sustav, koje bi moglo biti odgovorno za konstipacijski učinak fentanila.
English: • The patches are waterproof
Croatian: • Flasteri su vodootporni
English: Contents of the pack and other information What DUROGESIC contains [To be completed nationally]
Croatian: Sadržaj pakiranja i druge informacije Što DUROGESIC sadrži
English: These actions can be followed by administration of a specific opioid antagonist such as naloxone.
Croatian: Nakon tih mjera može se primijeniti specifičan opioidni antagonist, kao što je nalokson.
English: Monitoring of the patient for adverse events, which may include hypoventilation, is recommended for at least 48 hours after initiation of DUROGESIC therapy or up-titration of the dose (see section 4.4).
Croatian: Zbog moguće pojave nuspojava, koje mogu uključivati hipoventilaciju, preporučuje se nadzirati bolesnike tijekom najmanje 48 sati nakon uvođenja liječenja lijekom DUROGESIC ili nakon povećanja doze (vidjeti dio 4.4).
English: Therefore, the concomitant use of DUROGESIC and CYP3A4 inhibitors is not recommended unless the benefits outweigh the increased risk of adverse effects.
Croatian: Stoga se ne preporučuje istodobna primjena lijeka DUROGESIC i inhibitora CYP3A4, osim u slučajevima kada koristi nadmašuju povećan rizik od nuspojava.
English: The displayed frequency categories use the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare
Croatian: Prikazane kategorije učestalosti definirane su na sljedeći način: vrlo često (≥ 1/10); često (≥ 1/100 i
English: Among the remaining 5 subjects with a starting dosage of at least 25 mcg/h whose prior opioid doses were <45 mg of oral morphine equivalents per day, 1 (0.6%) had previously been receiving <30 mg of oral morphine equivalents per day and 4 (2.2%) had been receiving 30 to 44 mg of oral morphine equivalents per day (see section 4.8).
Croatian: Među preostalih 5 ispitanika s početnom dozom od najmanje 25 µg/h koji su prethodno primali doze opioida ekvivalentne < 45 mg oralnog morfina na dan, 1 (0,6%) je ispitanik prethodno primao dozu opioida ekvivalentnu < 30 mg oralnog morfina na dan, dok su njih 4 (2,2%) primala dozu opioida ekvivalentnu 30 do 44 mg oralnog morfina na dan (vidjeti dio 4.8).
English: Patches that are cut, divided, or damaged in any way should not be used.
Croatian: raspolovljeni ili oštećeni na bilo koji način.
English: The effects of the inducer decline gradually and may result in increased fentanyl plasma concentrations, which could increase or prolong both the therapeutic and adverse effects, and may cause serious respiratory depression.
Croatian: Učinci induktora smanjuju se postupno te mogu dovesti do porasta koncentracija fentanila u plazmi, što može pojačati ili produljiti i terapijske učinke i nuspojave te uzrokovati ozbiljnu depresiju disanja.
English: DUROGESIC can affect your ability to drive and use machines or tools as it may make you sleepy or dizzy.
Croatian: DUROGESIC može utjecati na Vašu sposobnost upravljanja vozilima i rada s alatima jer može izazvati pospanost ili omaglicu.
English: Very rarely these breathing difficulties can be life-threatening or even fatal, especially in people who have not used strong opioid painkillers (like DUROGESIC or morphine) before.
Croatian: Vrlo rijetko te dišne tegobe mogu biti opasne po život ili čak imati smrtni ishod, osobito kod ljudi koji prije nisu uzimali jake opioidne lijekove protiv bolova (poput lijeka DUROGESIC ili morfina).
English: If paralytic ileus is present or suspected, treatment with DUROGESIC should be stopped.
Croatian: U slučaju prisutnosti ili sumnje na paralitički ileus, liječenje lijekom DUROGESIC mora se prekinuti.
English: By the end of the second 72-hour application, a steady-state serum concentration is reached and is maintained during subsequent applications of a patch of the same size.
Croatian: Do kraja druge 72-satne primjene, koncentracija u serumu postiže stanje dinamičke ravnoteže, koje se održava daljnjom primjenom flastera iste veličine.
English: The serum fentanyl concentrations attained are proportional to the DUROGESIC patch size.
Croatian: Postignute koncentracije fentanila u serumu razmjerne su veličini DUROGESIC flastera.
English: The potential for serious or life-threatening hypoventilation exists regardless of the dose of DUROGESIC transdermal system administered.
Croatian: Mogućnost nastupa ozbiljne ili po život opasne hipoventilacije postoji neovisno o primijenjenoj dozi DUROGESIC transdermalnog flastera.
English: • Some medicines used to treat epilepsy (such as carbamazepine, phenobarbital, or phenytoin).
Croatian: • neke lijekove koji se koriste za liječenje epilepsije (npr. karbamazepin, fenobarbital ili fenitoin)
English: Starting dosages of 25 mcg/h and higher were used by the remaining 179 subjects, 174 (97.2%) of whom had been on opioid doses of at least 45 mg of oral morphine equivalents per day.
Croatian: Kod preostalih 179 ispitanika primjenjivale su se početne doze od 25 µg/h i više; 174 (97,2%) od tih ispitanika prethodno su primala doze opioida ekvivalentne najmanje 45 mg oralnog morfina na dan.
English: Dose adjustments should be done in 12 mcg/h steps.
Croatian: Dozu treba prilagođavati u koracima od 12 µg/h.
English: • Being unable to pass urine or empty bladder completely
Croatian: • nemogućnost mokrenja ili nepotpuno pražnjenje mjehura
English: Stopping suddenly may make you feel unwell
Croatian: Ako iznenadno prestanete primjenjivati flastere, možete se osjećati loše
English: Dose titration and maintenance therapy The DUROGESIC patch should be replaced every 72 hours.
Croatian: Titracija doze i terapija održavanja DUROGESIC flaster mora se mijenjati svaka 72 sata.
English: nausea (35.7%), vomiting (23.2%), constipation (23.1%), somnolence (15.0%), dizziness (13.1%), and headache (11.8%).
Croatian: somnolencija (15,0%), omaglica (13,1%) i glavobolja (11,8%).
English: Generally, the transdermal route is not recommended in opioid-naïve patients.
Croatian: Načelno se transdermalni put primjene ne preporučuje kod bolesnika koji prethodno nisu primali opioide.
English: DUROGESIC is for transdermal use.
Croatian: DUROGESIC je namijenjen za transdermalnu primjenu.
English: Cardiac disease
Croatian: Srčana bolest
English: Used patches should be folded firmly in half so that the sticky side of the patch sticks to itself.
Croatian: Upotrebljeni flasteri moraju se čvrsto presavinuti popola i to tako da ljepljiva strana naliježe sama na sebe.
English: It is recommended that DUROGESIC is used in patients who have demonstrated opioid tolerance (see section 4.2).
Croatian: Preporučuje se DUROGESIC koristiti kod bolesnika koji su pokazali toleranciju na opioide (vidjeti dio 4.2).
English: • DUROGESIC may make you unusually drowsy, and make your breathing more slow or shallow.
Croatian: • DUROGESIC može izazvati neuobičajenu omamljenost te sporije ili pliće disanje.
English: 1a parenteral buprenorphine sublingual parenteral codeine oral parenteral
Croatian: 1a parenteralni buprenorfin sublingvalni parenteralni kodein peroralni parenteralni
English: The safety of DUROGESIC was evaluated in 3 open-label studies in 289 paediatric subjects with chronic pain, aged 2 to 17 years, inclusive.
Croatian: Sigurnost lijeka DUROGESIC ocjenjivala se u 3 otvorena klinička ispitivanja provedena kod 293 pedijatrijska ispitanika s kroničnom boli u dobi između (i uključujući) 2 i 17 godina.
English: Chronic pulmonary disease
Croatian: Kronična plućna bolest
English: The appropriate initiating dose of DUROGESIC should be based on the patient's current opioid use.
Croatian: Odabir početne doze Odgovarajuću početnu dozu lijeka DUROGESIC treba temeljiti na bolesnikovoj trenutnoj primjeni opioida.
English: The extent of the interactions of CYP3A4 inhibitors with long-term transdermal fentanyl administration is not known, but may be greater than with short-term intravenous administration.
Croatian: Opseg interakcija između inhibitora CYP3A4 i dugotrajne transdermalne primjene fentanila nije poznat, ali mogao bi biti veći od onoga koji nastupa kod kratkotrajne intravenske primjene.
English: 20b ketobemidone oral parenteral levorphanol oral parenteral
Croatian: 20b ketobemidon peroralni parenteralni levorfanol peroralni parenteralni
English: Accidental transfer of a fentanyl patch to the skin of a non-patch wearer (particularly a child), while sharing a bed or being in close physical contact with a patch wearer, may result in an opioid overdose for the non-patch wearer.
Croatian: • Slučajnim prijenosom flastera s fentanilom na kožu osobe koja ga inače ne koristi (osobito djeteta) prilikom boravka u istom krevetu ili bliskog fizičkog kontakta s osobom koja koristi flaster, osoba koja ne koristi flaster može se predozirati opioidom.
English: What DUROGESIC looks like and contents of the pack [To be completed nationally]
Croatian: Kako DUROGESIC izgleda i sadržaj pakiranja
English: In opioid-naïve elderly patients, treatment should only be considered if the benefits outweigh the risks.
Croatian: Kod starijih bolesnika koji prethodno nisu primali opioide, liječenje treba razmotriti samo ako koristi nadmašuju rizike.
English: • Itchy skin rash (eczema), allergic reaction or other skin disorders where the patch is placed
Croatian: • osip kože praćen svrbežom (ekcem), alergijska reakcija ili drugi kožni poremećaji na mjestu postavljanja flastera • bolest nalik gripi
English: Elderly patients should be observed carefully and the dose should be individualised based upon the status of the patient (see sections 4.4 and 5.2).
Croatian: Starije bolesnike treba pažljivo nadzirati, a dozu prilagoditi svakom bolesniku pojedinačno na temelju njegova statusa (vidjeti dijelove 4.4 i 5.2).
English: 1 In clinical studies these ranges of daily oral morphine doses were used as a basis for conversion to DUROGESIC.
Croatian: 1 U kliničkim su ispitivanjima ovi rasponi dnevne doze oralnog morfina korišteni kao osnova za preračunavanje u doze lijeka DUROGESIC.
English: More than one DUROGESIC patch may be used for doses greater than 100 mcg/h.
Croatian: Za doze veće od 100 µg/h može se koristiti više od jednog DUROGESIC flastera.
English: 2 In clinical studies these ranges of daily oral morphine doses were used as a basis for conversion to DUROGESIC.
Croatian: 2 U kliničkim su ispitivanjima ovi rasponi dnevne doze oralnog morfina korišteni kao osnova za preračunavanje u doze lijeka DUROGESIC.
English: • While you are wearing the patch do not expose it to direct heat such as heating pads, electric blankets, hot-water bottles, heated water beds, heat or tanning lamps.
Croatian: • Dok nosite flaster, nemojte ga izlagati izravnim izvorima topline kao što su jastučići za zagrijavanje, električni pokrivači, termofori, zagrijani vodeni kreveti, lampe za grijanje ili sunčanje.
English: Generally, a patient should wait for 2 days after stopping treatment with a CYP3A4 inhibitor before applying the first DUROGESIC patch.
Croatian: Bolesnik u načelu treba pričekati 2 dana nakon završetka liječenja inhibitorom CYP3A4 prije nego što primijeni prvi DUROGESIC flaster.
English: Equianalgesic potency conversion In patients currently taking opioid analgesics, the starting dose of DUROGESIC should be based on the daily dose of the prior opioid.
Croatian: Kod bolesnika koji trenutno uzimaju opioidne analgetike, početnu doza lijeka DUROGESIC treba temeljiti na dnevnoj dozi dotadašnjeg opioida.
English: Patients reach and maintain a steady-state serum concentration that is determined by individual variation in skin permeability and body clearance of fentanyl.
Croatian: Koncentraciju u serumu u stanju dinamičke ravnoteže koju bolesnici postižu i održavaju, određuju individualne razlike u propusnosti kože i klirensu fentanila iz tijela.
English: • There is enough medicine in each patch to last 3 days (72 hours).
Croatian: Upotreba i mijenjanje flastera • U svakom pojedinom flasteru ima dovoljno lijeka za 3 dana (72 sata).
English: • Allergic reaction
Croatian: • alergijska reakcija • gubitak teka
English: • Feeling very tired, weak or generally unwell
Croatian: • izrazit umor, slabost ili opće loše osjećanje
English: The concomitant use of DUROGESIC with cytochrome P450 3A4 (CYP3A4) inhibitors may result in an increase in fentanyl plasma concentrations, which could increase or prolong both the therapeutic and adverse effects, and may cause serious respiratory depression.
Croatian: Istodobna primjena lijeka DUROGESIC i inhibitora izoenzima 3A4 citokroma P450 (CYP3A4) može dovesti do povećanja koncentracije fentanila u plazmi, što može pojačati ili produljiti i terapijske učinke i nuspojave te uzrokovati ozbiljnu depresiju disanja.
English: Avoid touching the adhesive side of the patch.
Croatian: Treba izbjegavati dodirivanje ljepljive strane flastera.
English: • Itching, skin rash or redness of the skin
Croatian: • svrbež, osip ili crvenilo kože
English: Patients with renal or hepatic impairment should be observed carefully and the dose should be individualised based upon the status of the patient (see sections 4.4 and 5.2).
Croatian: Bolesnike s oštećenjem bubrežne ili jetrene funkcije treba pažljivo nadzirati, a dozu prilagoditi svakom bolesniku pojedinačno na temelju njegova statusa (vidjeti dijelove 4.4 i 5.2).
English: Based on pooled safety data from these 3 clinical studies in paediatric subjects, the most commonly reported (i.e. ≥10% incidence) adverse reactions were vomiting (33.9%), nausea (23.5%), headache
Croatian: Prema objedinjenim podacima o sigurnosti iz tih kliničkih ispitivanja, najčešće prijavljene nuspojave (incidencija ≥ 10%) bile su: mučnina (35,7%), povraćanje (23,2%), konstipacija (23,1%),
English: • Some antihistamines, especially ones that make you sleepy (such as chlorpheniramine, clemastine,
Croatian: • neke antihistaminike, posebice one koji Vas uspavljuju (npr. klorfeniramin, klemastin, ciproheptadin, difenhidramin ili hidroksizin)
English: In these cases, only DUROGESIC 12 mcg/h dosage should be considered for initial treatment.
Croatian: U tim slučajevima za početno liječenje smije se razmotriti samo doza lijeka DUROGESIC od 12 µg/h.
English: • If your patches keep falling off, talk to your doctor, pharmacist or nurse
Croatian: • Ako se flaster nastavi odljepljivati, obratite se svom liječniku, ljekarniku ili medicinskoj sestri
English: DUROGESIC should be administered only to opioid-tolerant children age 2 years or older (see section 4.2).
Croatian: DUROGESIC se smije primjenjivati isključivo kod djece s tolerancijom na opioide u dobi od 2 ili više godina (vidjeti dio 4.2).
English: • Never divide or cut the patch
Croatian: • Nikada nemojte raspolavljati ili rezati flaster 3. korak:Odlijepite i pritisnite
English: [See Annex I - To be completed nationally]
Croatian: <[Vidjeti Prilog I. - ispunjava država članica]>
English: Do not use DUROGESIC if you are breastfeeding.
Croatian: Nemojte primjenjivati DUROGESIC ako dojite.
English: Putting a patch on
Croatian: Zalijepite flaster u
English: The potential for serious or life-threatening hypoventilation exists even if the lowest dose of DUROGESIC is used in initiating therapy in opioid-naïve patients, especially in elderly or patients with hepatic or renal impairment.
Croatian: Mogućnost nastupa ozbiljne ili po život opasne hipoventilacije postoji čak i kada se liječenje bolesnika koji prethodno nisu primali opioide započinje najnižom dozom lijeka DUROGESIC, osobito kod starijih bolesnika te bolesnika s oštećenjem jetrene ili bubrežne funkcije.
English: • Loss of contractions of the gut (ileus)
Croatian: • zastoj rada crijeva (ileus)
English: - Don't put a tight or elasticated band over the patch
Croatian: - nemojte koristiti vruće hidromasažne kade - nemojte stavljati tijesnu ili elastičnu traku preko flastera
English: Previous analgesic therapy should therefore be gradually phased out after the initial dose application until analgesic efficacy with DUROGESIC is attained.
Croatian: Stoga nakon početka primjene lijeka DUROGESIC prethodnu analgetsku terapiju treba postupno ukidati dok DUROGESIC ne postigne svoj analgetski učinak.
English: Data from intravenous studies with fentanyl suggest that elderly patients may have reduced clearance, a prolonged half-life, and they may be more sensitive to the active substance than younger patients.
Croatian: Podaci dobiveni u ispitivanjima fentanila za intravensku primjenu pokazuju da stariji bolesnici mogu imati smanjen klirens i dulji poluvijek lijeka te da mogu biti osjetljiviji na djelatnu tvar nego mlađi bolesnici.
English: Erectile dysfunction, Sexual dysfunction
Croatian: Poremećaji reproduktivno g sustava i dojki erektilna disfunkcija, seksualna disfunkcija
English: The conversion schedule should not be used to convert from DUROGESIC into other opioids, as overdosing could then occur.
Croatian: Taj se način preračunavanja doze ne smije primijeniti kada se DUROGESIC transdermalni flaster zamjenjuje drugim opioidima jer može doći do predoziranja.
English: DUROGESIC and alcohol Do not drink alcohol while using DUROGESIC unless you have talked to your doctor first.
Croatian: Nemojte piti alkohol dok primjenjujete DUROGESIC ako o tome prethodno niste razgovarali sa svojim liječnikom.
English: 6b fentanyl oral parenteral hydromorphone oral parenteral
Croatian: 6b fentanil peroralni parenteralni hidromorfon peroralni parenteralni
English: Co-administration of fentanyl with a serotonergic medicinal products, such as a Selective Serotonin Re-uptake Inhibitor (SSRI) or a Serotonin Norepinephrine Re-uptake Inhibitor (SNRI) or a Monoamine Oxidase Inhibitor (MAOI), may increase the risk of serotonin syndrome, a potentially life threatening condition.
Croatian: Serotoninergički lijekovi Istodobna primjena fentanila i serotoninergičkih lijekova, poput selektivnih inhibitora ponovne pohrane serotonina (SSRI), inhibitora ponovne pohrane serotonina i noradrenalina (SNRI) ili inhibitora monoaminooksidaze (MAOI), može povećati rizik od pojave serotoninskog sindroma,
English: 6.5 Nature and contents of container [To be completed nationally]
Croatian: 6.5 Vrsta i sadržaj spremnika
English: Fentanyl is a high clearance active substance and is rapidly and extensively metabolised primarily by CYP3A4 in the liver.
Croatian: Fentanil je djelatna tvar s visokim klirensom te se brzo i opsežno metabolizira u jetri, prvenstveno putem CYP3A4.
English: Table 1: Conversion Table - Multiplication Factors for Converting the Daily Dose of Prior Opioids to the Equianalgesic 24-hour Oral Morphine Dose (mg/day Prior Opioid x Factor = Equianalgesic 24-hour Oral Morphine Dose) Prior Opioid
Croatian: Tablica 1: Tablica za preračun doze - multiplikacijski faktori za preračun dnevne doze dosadašnjeg opioida u ekvianalgetsku 24-satnu dozu oralnog morfina (mg/dan dosadašnjeg opioida x faktor = ekvianalgetska 24-satna doza oralnog morfina) Dosadašnji opioid
English: When you are wearing the patch do not expose it to direct heat such as heating pads, electric blankets, hot-water bottles, heated water beds or heat or tanning lamps.
Croatian: Kada nosite flaster, nemojte ga izlagati izravnim izvorima topline kao što su jastučići za zagrijavanje, električni pokrivači, termofori, zagrijani vodeni kreveti te lampe za grijanje ili sunčanje.
English: Fentanyl, a high clearance active substance, is rapidly and extensively metabolised mainly by CYP3A4.
Croatian: Fentanil, djelatna tvar s visokim klirensom, brzo se i opsežno metabolizira, prvenstveno putem CYP3A4.
English: • If you have any further questions, ask your doctor, pharmacist or nurse
Croatian: • Ako imate dodatnih pitanja, obratite se liječniku, ljekarniku ili medicinskoj sestri.
English: Accidental exposure by patch transfer
Croatian: • Slučajno izlaganje prijenosom flastera
English: The interval between IV antagonist doses should be carefully chosen because of the possibility of re-narcotization after the patch is removed; repeated administration or a continuous infusion of naloxone may be necessary.
Croatian: Zbog mogućnosti ponovnog nastupa narkotičkih učinaka nakon uklanjanja flastera, potrebno je pažljivo odrediti vremenski razmak između intravenskih doza antagonista; možda će biti potrebna ponovna primjena ili kontinuirana infuzija naloksona.
English: The concomitant use of transdermal fentanyl with CYP3A4 inducers may result in a decrease in fentanyl plasma concentrations and a decreased therapeutic effect.
Croatian: Induktori CYP3A4 • Istodobna primjena transdermalnog fentanila s induktorima CYP3A4 može dovesti do smanjenja koncentracije fentanila u plazmi i smanjenog terapijskog učinka.
English: There have been very rare reports of newborn infants experiencing neonatal withdrawal syndrome when mothers chronically used DUROGESIC during pregnancy (see section 4.6).
Croatian: Kod novorođenčadi čije su majke kronično koristile DUROGESIC tijekom trudnoće vrlo su rijetko prijavljeni slučajevi neonatalnog sindroma ustezanja (vidjeti dio 4.6).
English: How long to keep DUROGESIC for
Croatian: Koliko dugo treba čuvati DUROGESIC
English: DUROGESIC can make you drowsy or breathe more slowly.
Croatian: DUROGESIC može izazvati omamljenost ili usporiti disanje.
English: • You have a condition called ‘myasthenia gravis' in which muscles become weak and tire easily.
Croatian: • ako ste starije dobi - možete biti osjetljiviji na učinke ovog lijeka • ako imate bolest koja se zove „miastenija gravis“, kod koje mišići slabe i lako se umaraju
English: Apply the patch to the skin by applying light pressure with the palm of the hand for about 30 seconds.
Croatian: Flaster treba zalijepiti na kožu lagano ga pritišćući dlanom tijekom približno 30 sekundi i zatim provjeriti jesu li se rubovi pravilno sljubili uz kožu.
English: Therefore, patients with fever should be monitored for opioid undesirable effects and the DUROGESIC dose should be adjusted if necessary.
Croatian: Stoga bolesnike s vrućicom treba nadzirati kako bi se uočile moguće nuspojave opioida i po potrebi prilagoditi dozu lijeka DUROGESIC.
English: In opioid-naïve patients with renal or hepatic impairment, treatment should only be considered if the benefits outweigh the risks.
Croatian: Kod bolesnika s oštećenjem bubrežne ili jetrene funkcije koji prethodno nisu primali opioide, liječenje se smije razmotriti samo ako koristi nadmašuju rizike.
English: (<1/10,000); not known (cannot be estimated from the available clinical data).
Croatian: < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih kliničkih podataka).
English: Patients should be advised that if accidental patch transfer occurs, the transferred patch must be removed immediately from the skin of the non-patch wearer (see section
Croatian: Bolesnike treba upozoriti da se u slučaju slučajnog prijenosa flastera on mora odmah ukloniti s kože osobe koja ga inače ne koristi (vidjeti dio 4.9).
English: You might need a different patch strength when you restart
Croatian: Kod ponovnog početka primjene možda ćete trebati drugu jačinu flastera.
English: To convert opioid-tolerant patients from oral or parenteral opioids to DUROGESIC refer to Equianalgesic potency conversion below.
Croatian: Za prebacivanje bolesnika koji pokazuju toleranciju na opioide s peroralnih ili parenteralnih opioida na DUROGESIC, vidjeti odlomak 'Preračunavanje ekvianalgetske jačine' u nastavku.