FrancophonIA/ELRC3.0 huggingface dataset:
English: A meta-analysis of allogeneic transplant studies, including the results of nine prospective randomized trials, 8 retrospective studies and 1 case-controlled study, did not detect an effect on the risks of acute GvHD, chronic GvHD or early treatment-related mortality.
Croatian: Metaanaliza ispitivanja alogenih presađivanja, koja je obuhvatila rezultate 9 prospektivnih randomiziranih ispitivanja, 8 retrospektivnih ispitivanja i jednu studiju istraživanja parova, nije otkrila nikakav učinak na razvoj akutnog GvHD, kroničnog GvHD ili rane smrtnosti povezane s liječenjem.
English: Idiopathic or cyclic neutropenia: the recommended starting dose is 0.5 MU (5 µg)/kg/day as a single dose or in divided doses.
Croatian: Idiopatska ili ciklička neutropenija: preporučena početna doza je 0,5 MU (5 µg)/kg/dan u jednokratnoj ili podijeljenoj dozi.
English: The pre-filled syringe has an UltraSafe Needle Guard attached in order to protect from needle stick injury.
Croatian: Napunjena štrcaljka ima pričvršćen ultrasigurni štitnik za iglu radi zaštite od ozljeda ubodom iglom.
English: Patients having a bone marrow transplant after chemotherapy:
Croatian: Bolesnici određeni za transplantaciju koštane srži nakon kemoterapije:
English: Solution for injection/infusion.
Croatian: Otopina za injekciju/infuziju.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C, unless dilution has taken place in controlled and validated aseptic conditions.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja i uvjeti čuvanja prije primjene odgovornost su korisnika te ne bi smjeli biti dulji od 24 sata na temperaturi od 2°C do 8°C, osim ako se razrjeđivanje provelo u kontroliranim i validiranim aseptičkim uvjetima.
English: There are reports in the literature where the transplacental passage of filgrastim in pregnant women has been demonstrated.
Croatian: U literaturi ima izvješća o prolasku filgrastima kroz posteljicu u trudnica.
English: Intravenous (80 µg/kg/day) administration of filgrastim to rabbits during the period of organogenesis was maternally toxic and increased spontaneous abortion, post-implantation loss, and decreased mean live litter size and foetal weight were observed.
Croatian: Intravenska (80 g/kg/dan) primjena filgrastima u kunića tijekom razdoblja organogeneze bila je toksična za majku i zabilježen je povećan broj spontanih pobačaja, gubitaka nakon implantacije te smanjena srednja veličina legla i težina fetusa.
English: There is insufficient data to further evaluate filgrastim use in paediatric subjects.
Croatian: Podaci nisu dostatni za dodatnu procjenu primjene filgrastima u pedijatrijskih ispitanika.
English: Do not use this medicine if you notice it is cloudy or there are particles in it.
Croatian: Ovaj lijek se ne smije upotrijebiti ako primijetite da je otopina zamućena ili sadrži čestice.
English: Chronic GvHD
Croatian: kronični GvHD
English: Offspring of rats administered filgrastim during the peri-natal and lactation periods, exhibited a delay in external differentiation and growth retardation (≥ 20 µg/kg/day) and slightly reduced survival rate (100 µg/kg/day).
Croatian: Potomstvo štakora kojima je primjenjivan filgrastim u perinatalnoj fazi i tijekom razdoblja laktacije, pokazuje kašnjenje u vanjskoj diferencijaciji i retardaciju rasta (≥ 20 g/kg/dan) te nešto nižu stopu preživljenja (100 g/kg/dan).
English: Use of filgrastim, either alone, or after chemotherapy, mobilises haematopoietic progenitor cells into the peripheral blood.
Croatian: Primjenom filgrastima, samog ili nakon kemoterapije, mobiliziraju se hematopoetske krvotvorne matične stanice iz periferne krvi.
English: Nivestim may have a minor influence on your ability to drive and use machines.
Croatian: Nivestim može malo utjecati na Vašu sposobnost upravljanja vozilima i rada sa strojevima.
English: Filgrastim is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 x 10
Croatian: Filgrastim je indiciran za liječenje perzistentne neutropenije (ABN manji ili jednak 1,0 × 10
English: It is advisable to wait and see how you feel after taking Nivestim and before driving or operating machinery.
Croatian: Savjetuje se da pričekate i vidite kako se osjećate nakon uzimanja
English: - if you have a combination of any of the following symptoms: o fever, or shivering, or feeling very cold, high heart rate, confusion or disorientation, shortness of breath, extreme pain or discomfort and clammy or sweaty skin.
Croatian: - ako imate kombinaciju bilo kojih od sljedećih simptoma: o vrućicu ili drhtanje, odnosno osjećaj velike hladnoće, ubrzane otkucaje srca, smetenost ili dezorijentiranost, nedostatak zraka, izrazit bol ili neugodu i ljepljivu ili znojnu kožu.
English: Since lithium promotes the release of neutrophils, lithium is likely to potentiate the effect of filgrastim.
Croatian: Budući da litij pospješuje otpuštanje neutrofila, mogao bi pojačati učinak filgrastima.
English: Some patients may respond very rapidly and with a considerable increase in neutrophil count to the initial dose of filgrastim.
Croatian: Neki bolesnici mogu reagirati vrlo brzo na početnu dozu filgrastima znatnim povećanjem broja neutrofila.
English: Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2)
Croatian: Lijek se izdaje na ograničeni recept (vidjeti Prilog I.: Sažetak opisa svojstava lijeka, dio 4.2).
English: Hypersensitivity-type reactions including anaphylaxis, rash, urticaria, angioedema, dyspnoea and hypotension occurring on initial or subsequent treatment have been reported in clinical studies and in post-marketing experience.
Croatian: Reakcije preosjetljivosti, uključujući anafilaksiju, osip, urtikariju, angioedem, dispneju i hipotenziju, na početku liječenja ili kasnije tijekom liječenja prijavljene su u kliničkim ispitivanjima te nakon stavljanja lijeka u promet.
English: Platelet counts should be monitored closely, especially during the first few weeks of filgrastim therapy.
Croatian: Treba pozorno nadzirati broj trombocita, osobito tijekom prvih tjedana primjene filgrastima.
English: Acute Grade II - IV GvHD
Croatian: N Stupanj akutnogGvHDa II - IV
English: When diluted in 5% glucose solution, filgrastim is compatible with glass and a variety of plastics including PVC, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Croatian: Kada se razrjeđuje u 5%-tnoj otopini glukoze, filgrastim je kompatibilan sa staklom i različitim vrstama plastike, uključujući PVC, poliolefin (ko-polimer polipropilena i polietilena) i polipropilen.
English: Dose adjustment: Filgrastim should be administered daily by subcutaneous injection until the neutrophil count has reached and can be maintained at more than 1.5 x 10
Croatian: Prilagodba doze: Filgrastim treba davati svakodnevno supkutanom injekcijom sve dok broj neutrofila ne dosegne 1,5 x 10
English: Oedema peripheral e
Croatian: Periferni edem
English: Some cytotoxic agents exhibit particular toxicities to the haematopoietic progenitor pool, and may adversely affect progenitor mobilisation.
Croatian: Neki citotoksični lijekovi osobito su toksični za krvotvorne matične stanice i mogu štetno utjecati na njihovu mobilizaciju.
English: Do not administer filgrastim to patients with a history of hypersensitivity to filgrastim or pegfilgrastim.
Croatian: Ne primjenjujte filgrastim u bolesnika s preosjetljivošću na filgrastim ili pegfilgrastim u anamnezi.
English: Filgrastim did not affect reproductive performance or fertility in male or female rats (see section 5.3).
Croatian: Filgrastim nije utjecao na reproduktivnu sposobnost ili plodnost u mužjaka i ženki štakora (vidjeti dio
English: 9/L, and a history of severe or recurrent infections, long term administration of filgrastim is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.
Croatian: 9/l i s teškim ili rekurentnim infekcijama u anamnezi, dugotrajna primjena filgrastima se koristi za povećanje broja neutrofila i za smanjenje učestalosti i trajanja poremećaja povezanih s infekcijom.
English: Myelodysplastic syndrome or Chronic myeloid leukaemia
Croatian: Mijelodisplastični sindrom ili kronična mijeloična leukemija
English: Filgrastim may be given as a daily subcutaneous injection or as a daily intravenous infusion diluted in 5% glucose solution given over 30 minutes (see section 6.6).
Croatian: Filgrastim se može davati kao dnevna supkutana injekcija ili dnevna intravenska infuzija razrijeđena u 5%-tnoj otopini glukoze koja se daje tijekom 30 minuta (vidjeti dio 6.6).
English: • rejection of transplanted bone marrow (graft versus host disease)
Croatian: • odbacivanje transplantirane koštane srži (bolest presatka protiv primatelja)
English: This medicine contains less than 1 mmol sodium (23 mg) per 0.6 mg/ml or 0.96 mg/ml dose, that is to say essentially ‘sodium-free'.
Croatian: Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po dozi od 0,6 mg/ml ili 0,96 mg/ml, tj. zanemarive količine natrija.
English: Use of filgrastim in patients, children or adults, with SCN (severe congenital, cyclic, and idiopathic neutropenia) induces a sustained increase in absolute neutrophil counts in peripheral blood and a reduction of infection and related events.
Croatian: Primjena filgrastima u bolesnika, djece ili odraslih s SCN-om (teškom kongenitalnom, cikličkom i idiopatskom neutropenijom) inducira se održivi porast ukupnog broja neutrofila u perifernoj krvi i smanjuje pojavnost infekcija i s njima povezanih događaja.
English: MANUFACTURER(S) OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Croatian: PROIZVOĐAČ(I) BIOLOŠKE DJELATNE TVARI I PROIZVOĐAČ(I) ODGOVORAN(ODGOVORNI) ZA PUŠTANJE SERIJE LIJEKA U PROMET
English: The safety and efficacy of filgrastim given on the same day as myelosuppressive cytotoxic chemotherapy have not been definitively established.
Croatian: Sigurnost i djelotvornost primjene filgrastima primijenjenog istog dana kada i mijelosupresivna citotoksična kemoterapija nisu definitivno potvrđene.
English: • swelling and/or fluid in the lungs (pulmonary oedema)
Croatian: • oticanje i/ili tekućina u plućima (plućni edem)
English: • get left upper belly (abdominal) pain, pain below the left rib cage or at the tip of your left shoulder (these may be symptoms of an enlarged spleen (splenomegaly), or possibly rupture of the spleen).
Croatian: • dobijete bol u gornjem lijevom dijelu trbuha (abdomena), bol ispod lijevog rebra ili u vršku lijevog ramena (to mogu biti simptomi uvećane slezene (splenomegalija) ili moguće rupture slezene).
English: If the ANC decreases to < 1.0 x 10
Croatian: Smanji li se ABN na < 1,0 x 10
English: Filgrastim may be given as a 30 minute or 24 hour intravenous infusion or given by continuous 24 hour subcutaneous infusion.
Croatian: Filgrastim se može davati kao 30-minutna ili 24-satna intravenska infuzija ili neprekidnom 24-satnom supkutanom infuzijom.
English: Use of filgrastim in patients undergoing cytotoxic chemotherapy leads to significant reductions in the incidence, severity and duration of neutropenia and febrile neutropenia.
Croatian: Primjenom filgrastima u bolesnika koji primaju citotoksičnu kemoterapiju značajno se smanjuje pojavnost, intenzitet i trajanje neutropenije i febrilne neutropenije.
English: Cases of Sweets syndrome (acute febrile neutrophilic dermatosis) have been reported in patients treated with filgrastim.
Croatian: Slučajevi Sweetovog sindroma (akutne febrilne neutrofilne dermatoze) prijavljeni su u bolesnika liječenih filgrastimom.
English: Cases of decreased bone density and osteoporosis have been reported in paediatric patients with severe chronic neutropenia receiving chronic treatment with filgrastim.
Croatian: Slučajevi smanjene gustoće kostiju i osteoporoze zabilježeni su u pedijatrijskih bolesnika s teškom kroničnom neutropenijom koji primaju kronično liječenje filgrastimom.
English: When reversal of neutropenia has been achieved, the minimal effective dose to maintain a normal neutrophil count should be established.
Croatian: Nakon što se korigira neutropenija, valja odrediti minimalnu dozu za održavanje normalnog broja neutrofila.
English: When diluted in 5% glucose solution, Nivestim is compatible with glass and a variety of plastics including PVC, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Croatian: Kad se razrjeđuje s 5%-tnom otopinom glukoze, Nivestim je kompatibilan sa staklom i različitim vrstama plastičnih materijala uključujući PVC, poliolefin (ko-polimer polipropilena i polietilena) i polipropilen.
English: During intermittent dosing with 30 MU (300 µg)/day of filgrastim, there can be wide fluctuations in the patient's ANC over time.
Croatian: Pri intermitentnoj primjeni 30 MU (300 µg) filgrastima/dan moguća su velika kolebanja ABN tijekom vremena.
English: There have been reports of GvHD and fatalities in patients after allogeneic bone marrow transplantation (see section c).
Croatian: Postojala su izvješća o GvHD i smrtnim slučajevima u bolesnika nakon alogene transplantacije koštane srži (vidjeti dio c).
English: Special caution should be used when treating patients with high dose chemotherapy, because improved tumour outcome has not been demonstrated and intensified doses of chemotherapeutic agents may lead to increased toxicities including cardiac, pulmonary, neurologic, and dermatologic effects (please refer to the prescribing information of the specific chemotherapy agents used).
Croatian: Nužan je poseban oprez pri liječenju bolesnika visokim dozama kemoterapeutika jer nije dokazano da se time postiže povoljniji ishod, a povišenje doze može dovesti do povećanja toksičnosti, uključujući učinke na srce, pluća, živčani sustav i kožu (molimo vidjeti sažetak opisa svojstava lijeka za određeni kemoterapeutik koji se koristi).
English: • pain in your mouth and throat (oropharyngeal pain)
Croatian: • bol u ustima i grlu (orofaringealna bol)
English: Leukapheresis should not be performed in donors who are anticoagulated or who have known defects in haemostasis.
Croatian: Leukafereza se ne smije provoditi u davatelja koji primaju antikoagulanse, kao ni u onih s poznatim poremećajima hemostaze.
English: Cases of capillary leak syndrome have been reported with granulocyte colony-stimulating factor use.
Croatian: Prijavljeni su slučajevi sindroma povećane propusnosti kapilara uz primjenu faktora stimulacije granulocitnih kolonija.
English: Keep the pre-filled syringe in the outer carton in order to protect from light.
Croatian: Čuvati napunjenu štrcaljku u vanjskoj kutiji radi zaštite od svjetlosti.
English: Slowly push down the plunger until all the contents of the syringe have been emptied.
Croatian: Laganim pritiskom klipa polako ubrizgajte otopinu sve dok se sav sadržaj štrcaljke ne isprazni.
English: • increase in white blood cells (leucocytosis)
Croatian: • porast broja bijelih krvnih stanica (leukocitoza)
English: In a small number of patients (< 10%), doses up to 1.0 MU (10 µg)/kg/day were required to achieve reversal of neutropenia.
Croatian: U malog broja bolesnika (< 10%) su za korekciju neutropenije bile nužne doze do 1,0 MU (10 µg)/kg/dan.
English: • experience puffiness in your face or ankles, blood in your urine or brown-coloured urine or you notice you urinate less than usual (glomerulonephritis).
Croatian: • opazite podbuhlost lica ili otečenost gležnjeva, krv u mokraći ili smeđe obojenu mokraću ili uočite da manje mokrite nego uobičajeno (glomerulonefritis).
English: Only clear solutions without particles should be used.
Croatian: Primijeniti se smije samo bistra otopina bez čestica.
English: Once the neutrophil nadir has been passed, the daily dose of filgrastim should be titrated against the neutrophil response as follows:
Croatian: Nakon što prođe vrijeme najnižih vrijednosti broja neutrofila, dnevnu dozu filgrastima treba određivati prema odgovoru neutrofila na sljedeći način:
English: Leukapheresis should be performed during the period when the ANC rises from < 0.5 x 10
Croatian: Leukaferezu treba obavljati tijekom razdoblja u kojem apsolutni broj neutrofila (ABN) poraste od < 0,5 x 10
English: Continuous infusion with filgrastim over a period of up to 28 days, in patients recovering from autologous bone-marrow transplantation, resulted in no evidence of drug accumulation and comparable elimination half-lives.
Croatian: Nema dokaza da kontinuirana infuzija filgrastima tijekom razdoblja do 28 dana u bolesnika koji su se oporavljali od presađivanja autologne koštane srži dovodi do nakupljanja lijeka te ima usporedivo poluvrijeme eliminacije.
English: Clearance of filgrastim has been shown to follow first-order pharmacokinetics after both subcutaneous and intravenous administration.
Croatian: Pokazalo se da klirens filgrastima slijedi farmakokinetiku prvog reda i nakon supkutane i nakon intravenske primjene.
English: Glomerulonephritis has been reported in patients receiving filgrastim and pegfilgrastim.
Croatian: Glomerulonefritis je zabilježen u bolesnika koji su primali filgrastim i pegfilgrastim.
English: Dose reductions of filgrastim have been noted to slow or stop the progression of splenic enlargement in patients with severe chronic neutropenia, and in 3% of patients a splenectomy was required.
Croatian: Pokazalo se da se povećanje slezene usporava ili zaustavlja smanjenjem doze filgrastima u bolesnika sa SCN-om, a u 3% bolesnika bila je potrebna splenektomija.
English: Pseudogout (chondrocalcinosis pyrophosphate)
Croatian: Pseudogiht (pirofosfatna hondrokalcinoza)
English: In patients undergoing a stem cell or bone marrow transplant, Graft versus host disease (GvHD) may occur - this is a reaction of the donor cells against the patient receiving the transplant; signs and symptoms include rash on the palms of your hands or soles of your feet and ulcer and sores in your mouth, gut, liver, skin, or your eyes, lungs, vagina and joints.
Croatian: U bolesnika koji se podvrgavaju transplantaciji matičnih stanica ili koštane srži može se javiti bolest presatka protiv primatelja (GvHD) - to je reakcija stanica davatelja protiv bolesnika koji prima transplantat; znakovi i simptomi uključuju osip na dlanovima ili tabanima i ulceracije i rane u ustima, trbuhu, jetri, koži ili na očima, plućima, vagini i zglobovima.
English: However, for a sustained therapeutic response, filgrastim therapy should not be discontinued before the expected nadir has passed and the neutrophil count has recovered to the normal range.
Croatian: No da bi se terapijski odgovor održao, primjena filgrastima se ne bi se trebala prekidati dok ne prođu očekivane najniže vrijednosti broja neutrofila i dok se broj neutrofila ne normalizira.
English: Cases were observed in the post-marketing setting in patients undergoing bone marrow transplant or PBPC mobilization.
Croatian: Slučajevi su uočeni u postmarketinškom okruženju u bolesnika koji se podvrgavaju transplantaciji koštane srži ili mobilizaciji KMSPK.
English: Physicians should use caution when prescribing filgrastim in patients with sickle cell trait or sickle cell disease.
Croatian: Liječnici moraju biti oprezni kada propisuju filgrastim bolesnicima s nasljednim obilježjem srpastih stanica ili bolešću srpastih stanica.
English: • sudden life-threatening allergic reaction (anaphylactic reaction)
Croatian: • iznenadna, po život opasna alergijska reakcija (anafilaktička reakcija)
English: • plum-coloured, raised, painful sores on the limbs and sometimes the face and neck with a fever
Croatian: • izdignute bolne promjene boje šljive na udovima i ponekad na licu i vratu praćene vrućicom (Sweetov sindrom)
English: Nivestim may have a minor influence on the ability to drive and use machines.
Croatian: Nivestim može malo utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Nivestim can be used: - to increase the number of white blood cells after treatment with chemotherapy to help prevent infections; - to increase the number of white blood cells after a bone marrow transplant to help prevent infections; - before high-dose chemotherapy to make the bone marrow produce more stem cells which can be collected and given back to you after your treatment.
Croatian: Za povećanje broja bijelih krvnih stanica nakon liječenja kemoterapijom, kako bi se pomoglo spriječiti infekcije; - Za povećanje broja bijelih krvnih stanica nakon transplantacije koštane srži, kako bi se pomoglo spriječiti infekcije; - Prije visokih doza kemoterapije, kako bi se potaknulo koštanu srž da proizvodi više matičnih stanica koje se mogu prikupiti i potom vratiti ih Vama natrag nakon liječenja.
English: 1 pre-filled syringe with 0.5 ml 5 pre-filled syringes with 0.5 ml 8 pre-filled syringes with 0.5 ml 10 pre-filled syringes with 0.5 ml
Croatian: 1 napunjena štrcaljka s 0,5 ml 5 napunjenih štrcaljki s 0,5 ml 8 napunjenih štrcaljki s 0,5 ml 10 napunjenih štrcaljki s 0,5 ml
English: Special precautions in SCN patients
Croatian: Posebne mjere opreza u bolesnika sa SCN
English: A diagnosis of splenic rupture should be considered in donors and/or patients reporting left upper abdominal or shoulder tip pain.
Croatian: Mogućnost rupture slezene valja uzeti u obzir u davatelja i/ili bolesnika koji se potuže na bol u lijevom gornjem dijelu abdomena ili vrhu ramena.
English: Capillary leak syndrome, which can be life-threatening if treatment is delayed, has been reported after granulocyte colony-stimulating factor administration, and is characterised by hypotension, hypoalbuminaemia, oedema and haemoconcentration.
Croatian: Sindrom povećane propusnosti kapilara, koji može ugrožavati život ako se ne počne liječiti na vrijeme, zabilježen je nakon primjene faktora stimulacije kolonije granulocita, a karakterizira ga hipotenzija, hipoalbuminemija, edem i hemokoncentracija.
English: Transformation to leukaemia or myelodysplastic syndrome
Croatian: Pretvorba u leukemiju ili mijelodisplastični sindrom
English: One retrospective European study evaluating the use of GCSF after allogeneic bone marrow transplantation in patients with acute leukaemias suggested an increase in the risk of GvHD, treatment related mortality (TRM) and mortality when GCSF was administered.
Croatian: Jedno retrospektivno europsko ispitivanje koje je procjenjivalo primjenu G-CSF-a nakon presađivanja alogenih stanica koštane srži u bolesnika s akutnom leukemijom ukazalo je na povećan rizik GvHD, smrtnost povezanu s liječenjem te smrtnost nakon primjene G-CSF.
English: (Cyprus Branch) Τηλ: +357 22 817690
Croatian: Pfizer ΕΛΛΑΣ Α.Ε. (Cyprus Branch) Τηλ: +357 22 817690
English: Congenital neutropenia: the recommended starting dose is 1.2 MU (12 µg)/kg/day as a single dose or in divided doses.
Croatian: Kongenitalna neutropenija: preporučena početna doza je 1,2 MU (12 µg)/kg/dan u jednokratnoj ili podijeljenoj dozi.
English: The most serious adverse reactions that may occur during filgrastim treatment include: anaphylactic reaction, serious pulmonary adverse events (including interstitial pneumonia and ARDS), capillary leak syndrome, severe splenomegaly/splenic rupture, transformation to myelodysplastic syndrome or leukaemia in SCN patients, GvHD in patients receiving allogeneic bone marrow transfer or peripheral blood cell progenitor cell transplant and sickle cell crisis in patients with sickle cell disease.
Croatian: Najozbiljnije nuspojave koje se mogu pojaviti tijekom liječenja filgrastimom uključuju: anafilaktičku reakciju, ozbiljne štetne plućne događaje (uključujući intersticijsku pneumoniju i sindrom akutnog respiratornog distresa), sindrom povećane propusnosti kapilara, tešku splenomegaliju/rupturu slezene, pretvorbu u mijelodisplastični sindrom ili leukemiju u bolesnika sa SCN-om, bolest presatka protiv primatelja (GvHD) u bolesnika podvrgnutih alogenoj transplantaciji koštane srži ili transplantaciji krvotvornih matičnih stanica periferne krvi te krizu srpastih stanica u bolesnika s bolešću srpastih stanica.