FrancophonIA/ELRC3.0 huggingface dataset:
English: • fibroid tumours of the uterus incompatible with pregnancy
Slovenian: • fibroidni tumorji maternice, nezdružljivi z nosečnostjo
English: No signs of toxicity due to the development of antibodies to lutropin alfa were observed.
Slovenian: Toksičnosti zaradi razvoja protiteles za lutropin alfa niso opazili.
English: Luteal phase support may be considered since lack of substances with luteotrophic activity (LH/hCG) after ovulation may lead to premature failure of the corpus luteum.
Slovenian: Pretehta naj se potrebnost podpore lutealne faze, ker pomanjkanje snovi z luteotropno aktivnostjo (LH/hCG) po ovulaciji lahko privede do prezgodnje odpovedi rumenega telesca.
English: Date of latest renewal: 30
Slovenian: Datum zadnjega podaljšanja: 30. november 2005.
English: The majority of multiple conceptions are twins.
Slovenian: V večini primerov večplodne nosečnosti gre za dvojčke.
English: • Immediately inject the solution: Your doctor or nurse will have already advised you where to inject (e.g. tummy, front of thigh).
Slovenian: • Takoj vbrizgajte raztopino: Vaš zdravnik ali sestra sta vas že poučila, kje dati injekcijo (npr. v trebuh, sprednjo stran stegna).
English: What Luveris is and what it is used for What you need to know before you use Luveris How to use Luveris
Slovenian: Kaj je zdravilo Luveris in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Luveris Kako uporabljati zdravilo Luveris Možni neželeni učinki
English: This side effect is common (may affect up to 1 in 10 people).
Slovenian: Ta neželeni učinek je pogost (pojavijo se lahko pri največ 1 od 10 bolnikov).
English: The vials are sealed with bromobutyl stoppers protected by aluminium seal rings and flip-off caps.
Slovenian: Viale so zaprte z bromobutilnimi zamaški, ki so zaščiteni z aluminijastimi zapornimi obročki in zaporkami, ki se odtrgajo na poteg.
English: When undergoing assisted reproductive technology or stimulation of your ovaries to produce eggs, you are more likely to have a miscarriage than the average woman.
Slovenian: Če poskušate zanositi z biomedicinsko pomočjo ali stimulacijo jajčnikov za proizvajanje jajčec, je verjetnost, da boste imeli spontani splav, večja kot pri povprečni ženski.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION
Slovenian: IME ZDRAVILA IN POT(I ) UPORABE
English: It is recommended not to use Luveris if you have any condition that usually makes a normal pregnancy impossible, such as ovaries that do not work because of a condition called primary ovarian failure, or malformations of sexual organs.
Slovenian: Jemanje zdravila Luveris ni priporočljivo, če imate stanje, ki običajno onemogoča normalno zanositev, kot je nedelovanje jajčnikov zaradi primarne odpovedi jajčnika ali malformacije spolnih organov.
English: In clinical trials, patients were defined by an endogenous serum LH level < 1.2 IU/l as measured in a central laboratory.
Slovenian: V kliničnih preskušanjih so bile bolnice opredeljene na podlagi serumske ravni endogenega LH < 1,2 i.e./l, izmerjene v centralnem laboratoriju.
English: • Local reactions at the injection site, such as pain, itching, bruising, swelling or irritation.
Slovenian: • lokalne reakcije na mestu injiciranja, kot so bolečina, srbenje, modrica, oteklina ali draženje.
English: The lutropin alfa pharmacokinetics following single and repeated administration of Luveris are comparable and the accumulation ratio of lutropin alfa is minimal.
Slovenian: Farmakokinetika lutropina alfa po enkratnem in večkratnem dajanju zdravila Luveris je primerljiva, stopnja akumulacije lutropina alfa pa je minimalna.
English: The reconstituted solution should not be administered if it contains particles or is not clear.
Slovenian: Rekonstituirane raztopine ne smemo uporabiti, če vsebuje delce ali ni bistra.
English: Luveris is intended for subcutaneous use.
Slovenian: Zdravilo Luveris je namenjeno subkutani uporabi.
English: Luveris has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Luveris nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: The solvent is packaged either in 2 or 3 ml neutral colourless glass (type I) vials with a Teflon-coated rubber stopper or in 2 ml neutral colourless glass (type I) ampoules.
Slovenian: Vehikel je pakiran bodisi v 2 ml ali 3 ml viale iz nevtralnega brezbarvnega stekla (tip I), z gumijastimi zamaški, prevlečenimi s teflonom ali v 2 ml ampule iz nevtralnega brezbarvnega stekla (tip I).
English: This increases your risk of developing Ovarian HyperStimulation Syndrome or OHSS.
Slovenian: To poveča tveganje za razvoj sindroma hiperstimulacije jajčnikov ali OHSS.
English: Adherence to recommended Luveris and FSH dosage and regimen of administration can minimise the risk of ovarian hyperstimulation.
Slovenian: Upoštevanje priporočenih odmerkov zdravila Luveris in FHS-ja ter režim dajanja lahko zmanjšata tveganje za hiperstimulacijo jajčnikov.
English: Luveris is a medicine containing lutropin alfa, a recombinant Luteinising Hormone (LH) which is essentially similar to the hormone found naturally in humans, but is made by means of biotechnology.
Slovenian: Luveris je zdravilo, ki vsebuje lutropin alfa, rekombinantni luteinizirajoči hormon (LH), ki je zelo podoben naravnemu hormonu pri ljudeh, vendar je izdelan s pomočjo biotehnologije.
English: Data on a limited number of exposed pregnancies indicate no adverse reactions of gonadotropins on pregnancy, embryonal or foetal development, parturition or postnatal development following controlled ovarian stimulation.
Slovenian: Podatki, zbrani pri omejenem številu nosečnic, ki so bile izpostavljene zdravilu, ne kažejo na možnost škodljivih vplivov gonadotropinov na nosečnost, razvoj zarodka ali plodu, porod ali postnatalni razvoj po nadzorovani stimulaciji jajčnikov.
English: Luteinising Hormone (LH) binds on the ovarian theca (and granulosa) cells and testicular Leydig cells, to a receptor shared with human chorionic gonadotropin hormone (hCG).
Slovenian: Luteinizirajoči hormon (LH) se veže na ovarijske teka (in granuloza) celice in na Leydigove celice testisov, na receptor, ki je skupen humanemu horionskemu gonadotropinskemu hormonu (hCG).
English: It comprises marked ovarian enlargement, high serum sex steroids, and an increase in vascular permeability which can result in an accumulation of fluid in the peritoneal, pleural and, rarely, in the pericardial cavities.
Slovenian: Vključuje izrazito povečanje jajčnikov, visoko serumsko koncentracijo spolnih steroidov ter povečanje žilne prepustnosti, kar lahko povzroči kopičenje tekočine v peritonealnem, plevralnem in redko v perikardialnem prostoru.
English: In clinical trials these patients were defined by an endogenous serum LH level <1.2 IU/l.
Slovenian: V kliničnih preskušanjih so te bolnice opredelili glede na serumsko raven endogenega LH < 1,2 i.e./l.
English: It is followed by treatment with a single dose of human Chorionic Gonadotropin (hCG), which leads to the release of an egg from the follicle (ovulation).
Slovenian: Temu sledi zdravljenje z enim samim odmerkom humanega horionskega gonadotropina (hCG), ki privede do sprostitve jajčeca iz folikla (ovulacije).
English: Torsion of the ovary and bleeding into the abdomen have not been reported with Luveris, however, there have been rare cases reported following treatment with human menopausal gonadotropin (hMG), a urine-derived medication also containing LH.
Slovenian: Pri zdravljenju z zdravilom Luveris ne poročajo o torziji jajčnika in krvavitvah v trebuh, obstajajo pa poročila o redkih primerih le-tega po zdravljenju s humanim menopavznim gonadotropinom (hMG-jem), ki je zdravilo urinskega izvora in vsebuje tudi LH.
English: In case you are not ovulating, and if the recommended dose and schedule of administration are adhered to, the occurrence of OHSS is less likely.
Slovenian: Če nimate ovulacije in če upoštevate priporočeni odmerek ter urnik dajanja, je pojav OHSS redek.
English: This could be due to parental factors (e.g. maternal age, genetics), ART procedures and multiple pregnancies.
Slovenian: Vzrok so lahko dejavniki pri starših (npr. starost matere, genetika), postopki ART in večplodna nosečnost.
English: In patients undergoing induction of ovulation, the incidence of multiple pregnancy and births is increased compared with natural conception.
Slovenian: Pri bolnicah v postopku indukcije ovulacije je pogostnost večplodne nosečnosti in rojstev povečana v primerjavi z naravno zanositvijo.
English: There is no relevant indication for the use of Luveris in the elderly population.
Slovenian: Ni relevantnih podatkov o uporabi zdravila Luveris pri starejši populaciji.
English: After dissolving the Luveris powder, draw the solution back into the syringe and re-inject it into the container with the follitropin alfa powder.
Slovenian: Ko se prašek zdravila Luveris raztopi, potegnite raztopino nazaj v brizgo in jo ponovno injicirajte v vsebnik s praškom folitropina alfa.
English: 75 IU
Slovenian: 75 i.e.
English: In order to avoid the injection of large volumes, one vial of Luveris can be reconstituted together with one or two ampoule(s)/vial(s) of follitropin alfa, 37.5 IU, 75 IU or 150 IU, in 1 ml of solvent.
Slovenian: V izogib injiciranju velikega volumna, lahko eno vialo zdravila Luveris rekonstituiramo skupaj z vsebino ene ali dveh ampul/vial s folitropinom alfa 37,5 i.e., 75 i.e. ali 150 i.e. v 1 ml vehikla.
English: If an FSH dose increase is deemed appropriate, dose adaptation should preferably be after 7-14 day intervals and preferably by 37.5 IU-75 IU increments.
Slovenian: Če je potrebno povečanje odmerka FSH-ja, moramo prilagoditev odmerka izvesti po možnosti v 7-14 dnevnih intervalih s povečanji po 37,5 i.e. do 75 i.e.
English: A recommended regimen commences at 75 IU of lutropin alfa (ie. one vial of Luveris) daily with 75-150 IU FSH.
Slovenian: Priporočeni režim se začne s 75 i.e. lutropina alfa (tj. Ena viala zdravila Luveris) na dan in s 75-150 i.e. FSH-ja.
English: Very rarely, severe OHSS may be complicated by ovarian torsion or thromboembolic events, such as pulmonary embolism, ischaemic stroke or myocardial infarction.
Slovenian: Zelo redko se lahko huda stopnja OHSS še dodatno zaplete s torzijo jajčnika ali trombemboličnimi dogodki, kot so pulmonalni embolizem, ishemična kap ali miokardni infarkt.
English: In addition, patients should be evaluated for hypothyroidism, adrenocortical deficiency and hyperprolactinemia and appropriate specific treatment given.
Slovenian: Poleg tega je pred začetkom zdravljenja bolnice treba pregledati še za hipotiroidizem, adrenokortikalno insuficienco in hiperprolaktinemijo ter jih ustrezno zdraviti.
English: Once the powder has dissolved, draw the solution back into the syringe.
Slovenian: Ko se prašek raztopi, potegnite raztopino nazaj v brizgo.
English: The powder should be reconstituted immediately prior to use with the solvent provided.
Slovenian: Prašek je treba rekonstituirati tik pred uporabo s priloženim vehiklom.
English: The effects of an overdose of Luveris are unknown, nevertheless there is a possibility that Ovarian Hyper-Stimulation Syndrome may occur, which is further described in ‘Possible side effects'.
Slovenian: Če ste uporabili večji odmerek zdravila Luveris, kot bi smeli Učinki prevelikega odmerka zdravila Luveris niso poznani, vseeno pa je možen pojav sindroma ovarijske hiperstimulacije, kar je podrobno opisano v „Možni neželeni učinki“.
English: The incidence of pregnancy loss by miscarriage or abortion is higher in patients undergoing stimulation of follicular growth for ovulation induction than following natural conception.
Slovenian: Pojavnost prekinitev nosečnosti zaradi spontanega splava ali abortusa je višja pri bolnicah, pri katerih stimulirajo rast foliklov za indukcijo ovulacije, kot po naravni zanositvi.
English: This may be associated with other risk factors such as OHSS, pregnancy, previous abdominal surgery, past history of ovarian torsion, previous or current ovarian cyst and polycystic ovarian syndrome.
Slovenian: To je lahko povezano z ostalimi dejavniki tveganja, kot so OHSS, nosečnost, predhodne operacije v trebušni votlini, zasuk jajčnika v anamnezi, predhodna ali trenutna cista jajčnika ali sindrom policističnega jajčnika.
English: In patients undergoing Assisted Reproductive Technology (ART) procedures the risk of multiple pregnancy is related mainly to the number of embryos replaced, their quality and the patient age.
Slovenian: Pri bolnicah, ki so bile udeležene v postopkih oploditve z biomedicinsko pomočjo (ART), je tveganje za večplodno nosečnost povezano predvsem s številom prenesenih zarodkov, njihovo kakovostjo in starostjo bolnice.
English: At doses of 10 IU/kg/day and greater, repeated administration of lutropin alfa to pregnant rats and rabbits caused impairment of reproductive function including resorption of foetuses and reduced body weight gain of the dams.
Slovenian: Pri odmerkih 10 i.e./kg/dan in več je ponovno dajanje lutropina alfa brejim podganam in zajkljam povzročilo okvare reproduktivne funkcije, vključno z resorpcijo fetusov in zmanjšanjem pridobivanja telesne mase samic.
English: Driving and using machines Luveris has no or negligible influence on the ability to drive and use machines.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Luveris nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: This medicinal product must not be administered as a mixture in the same injection with other medicinal products except follitropin alfa.
Slovenian: Zdravila ne smemo dajati kot mešanico v isti injekciji z drugimi zdravili, razen s folitropinom alfa.
English: • Remove the protective cap from the solvent vial.
Slovenian: • Odstranite zaščitno kapico z viale z vehiklom.
English: Marketing Authorisation Holder Merck Europe B.V.
Slovenian: Imetnik dovoljenja za promet z zdravilom Merck Europe B.V.
English: Luveris should be given as a course of daily injections simultaneously with FSH.
Slovenian: Zdravilo Luveris moramo dajati kot serijo dnevnih injekcij sočasno s FSH-jem.
English: Lutropin alfa is produced in genetically engineered Chinese Hamster Ovary (CHO) cells.
Slovenian: Lutropin alfa je pridobljen z gensko rekombinantno tehnologijo na ovarijskih celicah kitajskega hrčka (CHO).
English: When undergoing assisted reproductive technology the risk of having a multiple pregnancy is related to your age, the quality and the number of fertilised eggs or embryos placed inside you.
Slovenian: Če poskušate zanositi z biomedicinsko pomočjo, je tveganje za večplodno nosečnost povezano z vašo starostjo, kakovostjo in številom oplojenih jajčec ter vsajenih zarodkov.
English: Name and address of the manufacturer of the biological active substance Merck Serono SA
Slovenian: Ime in naslov izdelovalca biološke zdravilne učinkovine Merck Serono S.A.
English: Luveris is indicated for the stimulation of follicular development, in association with FSH (see section 4.1).
Slovenian: Zdravilo Luveris je indicirano za uporabo pri stimulaciji nastajanja foliklov v povezavi s FHS (glejte poglavje 4.1).
English: Turn the vial upside down and gently draw the solution back into the syringe.
Slovenian: Obrnite vialo navpično navzdol in previdno potegnite raztopino nazaj v brizgo.
English: In clinical trials, Luveris has been shown to increase the ovarian sensitivity to follitropin alfa.
Slovenian: V kliničnih preskušanjih se je pokazalo, da zdravilo Luveris poveča občutljivost jajčnikov na folitropin alfa.
English: The prevalence of ectopic pregnancy after ART was reported to be higher than in the general population.
Slovenian: Poročali so o višji prevalenci zunajmaternične nosečnosti po ART v primerjavi s splošno populacijo.
English: • Prepare the injection solution: Remove the protective cap from the Luveris powder vial, pick up your syringe and slowly inject the solvent into the vial of Luveris.
Slovenian: • Pripravite raztopino za injiciranje: Odstranite zaščitno kapico z viale s praškom zdravila Luveris, vzemite brizgo in počasi injicirajte vehikel v vialo z zdravilom Luveris.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION One vial contains 75 IU of lutropin alfa (recombinant human Luteinising Hormone {r-hLH}).
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Ena viala vsebuje 75 i.e. lutropina alfa (rekombinantnega humanega luteinizirajočega hormona, r-hLH).
English: • The usual starting dose is 75 IU (1 vial) of Luveris together with 75 IU or 150 IU of FSH.
Slovenian: • Običajni začetni odmerek je 75 i.e. (1 viala) zdravila Luveris, skupaj s 75 i.e. ali 150 i.e.
English: In this case Luveris should be reconstituted first and then used to reconstitute the follitropin alfa powder.
Slovenian: V takem primeru moramo najprej rekonstituirati zdravilo Luveris in ga nato uporabimo za rekonstitucijo praška folitropina alfa.
English: Birth defects after Assisted Reproductive Technology (ART) may be slightly higher than after spontaneous conceptions.
Slovenian: Prirojene okvare po oploditvah z biomedicinsko pomočjo (Assisted Reproductive Technology - ART) so lahko nekoliko višje kot po spontani zanositvi.
English: • tumours of the hypothalamus and pituitary gland
Slovenian: • s tumorji hipotalamusa in hipofize
English: Attach the reconstitution needle to the syringe and draw up some air into the syringe by pulling the plunger to approximately the 1 ml mark. Then, insert the needle into the vial, push the plunger to expel the air, turn the vial upside down and gently draw up all the solvent.
Slovenian: Pritrdite iglo za rekonstituiranje na brizgo in potegnite vanjo nekaj zraka, tako da potisnete bat približno do oznake 1 ml. Nato vstavite iglo v vialo, potisnete bat, da iztisnete zrak, obrnite vialo navpično navzdol in nežno potegnite v brizgo ves vehikel.
English: Common: Mild or moderate OHSS (including associated symptomatology), ovarian cyst, breast pain, pelvic pain
Slovenian: Pogosti: blagi do zmerni OHSS (vključno s povezano simptomatologijo), cista jajčnikov, bolečine v prsih, bolečine v medenici
English: INFORMATION IN BRAILLE luveris 75 iu
Slovenian: PODATKI V BRAILLOVI PISAVI luveris 75 i.e.
English: Paediatric population There is no relevant indication for the use of Luveris in the paediatric population.
Slovenian: Pediatrična populacija Zdravilo Luveris ni primerno za uporabo pri pediatrični populaciji.
English: • Lutropin alfa is recombinant human Luteinising Hormone (r-hLH), produced by recombinant DNA technology.
Slovenian: • Lutropin alfa je rekombinantni humani luteinizirajoči hormon (r-hLH), proizveden z rekombinantno DNA tehnologijo.
English: • If you have ovarian enlargement or sacs of fluid within the ovaries (ovarian cyst) of unknown origin.
Slovenian: • če imate povečanje jajčnika ali vrečke s tekočino v jajčnikih (cisto jajčnikov), ki je neznanega izvora,
English: Immediately withdraw the needle and clean the skin with an alcohol swab using a circular motion.
Slovenian: Takoj izvlecite iglo in s krožnimi gibi z alkoholno blazinico očistite kožo.
English: • If you have cancer of ovaries, uterus or breast.
Slovenian: • če so ugotovili, da imate raka jajčnikov, maternice ali dojke,
English: Do not use Luveris as a mixture with other medicines in the same injection, except for follitropin alfa, if prescribed by your doctor.
Slovenian: Zdravila Luveris ne smemo dajati kot mešanico z drugimi zdravili v isti injekcijski brizgi, razen s folitropinom alfa, če vam ga je predpisal zdravnik.
English: In a clinical trial, mild and moderate injection site reactions (bruising, pain, redness, itching or swelling) were reported in 7.4 % and 0.9 % of the injections, respectively.
Slovenian: V kliničnih preskušanjih so poročali o blagih in zmernih reakcijah na mestu injiciranja v 7,4 % oziroma 0,9 % (modrica, bolečina, rdečica, srbenje ali oteklina).
English: Therefore, if signs of ovarian hyperstimulation occur, it is recommended that hCG be withheld and the patient be advised to refrain from coitus or use barrier contraceptive methods for at least 4 days.
Slovenian: Če se torej pojavijo znaki hiperstimulacije jajčnikov, je priporočljivo, da dajanje hCG prekinete, bolnicam pa svetujemo, da v obdobju najmanj 4 dni nimajo spolnih odnosov ali da v tem času uporabljajo mehanska kontracepcijska sredstva.
English: After ovulation, LH stimulates progesterone production in the corpus luteum by increasing the conversion of cholesterol to pregnenolone.
Slovenian: Po ovulaciji LH v rumenem telescu spodbuja tvorbo progesterona, tako da poveča pretvorbo holesterola v pregnenolon.
English: Lutropin alfa is a recombinant human Luteinising Hormone (r-hLH), a glycoprotein composed of noncovalently bound α- and ß-subunits.
Slovenian: Lutropin alfa je rekombinantni humani luteinizirajoči hormon (r-hLH), glikoprotein sestavljen iz dveh nekovalentno povezanih α- in β-podenot.
English: What Luveris looks like and contents of the pack
Slovenian: Izgled zdravila Luveris in vsebina pakiranja
English: Ectopic pregnancy may also occur, especially in women with a history of prior tubal disease.
Slovenian: Pojavi se lahko tudi zunajmaternična nosečnost, še posebej pri ženskah z boleznijo jajcevodov v anamnezi.
English: You and your partner's fertility should be evaluated before the treatment is started.
Slovenian: Pred začetkom zdravljenja je treba oceniti vašo plodnost in plodnost vašega partnerja.
English: In case of exposure during pregnancy, clinical data are not sufficient to exclude a teratogenic effect of Luveris.
Slovenian: Za zdravilo Luveris ni na voljo kliničnih podatkov od nosečnic, ki so bile izpostavljene zdravilu, da bi izključili teratogene učinke zdravila Luveris.
English: Inject the solution by pushing gently on the plunger.
Slovenian: Raztopino vbrizgavajte tako, da nežno pritiskate na bat.
English: Luveris may be mixed with follitropin alfa and co-administered as a single injection.
Slovenian: Zdravilo Luveris lahko mešamo s folitropinom alfa in dajemo sočasno kot eno samo injekcijo.
English: Gently flick the top section of the ampoule so that any fluid in the neck of the ampoule drops into the bottom chamber.
Slovenian: Nežno krcnite po vrhnjem delu ampule, tako da vsa tekočina, ki je še morda v vratu ampule, odkaplja v spodnji predel.
English: These may be the symptoms of Ovarian Hyper-Stimulation Syndrome (OHSS).
Slovenian: To so lahko simptomi sindroma hiperstimulacije jajčnikov (OHSS).
English: Up to 3 containers of powder may be dissolved in 1 ml of solvent.
Slovenian: V 1 ml vehikla se lahko raztopi vsebina do 3 vial praška.
English: • Lower abdominal pain together with nausea or vomiting.
Slovenian: • Bolečina v spodnjem delu trebuha skupaj s slabostjo ali bruhanjem.
English: Do not use this medicine after the expiry date, which is stated on the vials after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na vialah poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: • Luveris comes as a powder and solvent for solution for injection.
Slovenian: • Zdravilo Luveris je na voljo kot prašek in vehikel za raztopino za injiciranje.
English: There have been reports of tumours in the ovaries and other sex organs, both benign and malignant, in women who have undergone multiple drug regimens for infertility treatment.
Slovenian: Obstajajo poročila o tumorjih na jajčnikih in drugod na spolnih organih, ki so lahko benigni in maligni, pri ženskah, ki so bile izpostavljene režimom zdravljenja neplodnosti z več zdravili.
English: Breast-feeding Luveris is not indicated during breast-feeding.
Slovenian: Dojenje Zdravilo Luveris ni indicirano med dojenjem.
English: In the ovaries, during the follicular phase, LH stimulates theca cells to secrete androgens, which will be used as the substrate by granulosa cell aromatase enzyme to produce estradiol, supporting FSH-induced follicular development.
Slovenian: Med folikularno fazo LH v jajčnikih spodbuja celice teka, da izločajo androgene, ki so substrat encimu aromatazi celic granuloza za tvorbo estradiola, ki podpira s FSH-jem sprožen razvoj foliklov.