FrancophonIA/ELRC3.0 huggingface dataset:
English: Other symptoms of Kaposi's sarcoma, such as swelling around the tumour, may also improve or disappear.
Croatian: Drugi simptomi Kaposijevog sarkoma, kao što su oticanje oko tumora, također se mogu smanjiti ili nestati.
English: Infusion reactions rarely recur after the first treatment cycle.
Croatian: Reakcije na infuziju rijetko se ponavljaju nakon prvog ciklusa liječenja.
English: For all patients
Croatian: Za sve bolesnike
English: Grade 4 (diffuse or local process causing infectious complications, or a bedridden state or hospitalisation)
Croatian: 4. stupanj (difuzni ili lokalni proces koji uzrokuje infekcijske komplikacije, ili vezanost za krevet ili hospitalizacija)
English: A similar, but less severe response was also noted in dogs treated with Caelyx and standard doxorubicin.
Croatian: Sličan, ali manje težak odgovor bio je primijećen i u pasa liječenih Caelyxom i standardnim doksorubicinom.
English: Maximum plasma concentration* (µg/ml) Plasma clearance (l/h/m Volume of distribution (l/m AUC (µg/mlh)
Croatian: Maksimalna koncentracija u plazmi* (µg/ml) Klirens iz plazme (l/h/m Volumen raspodjele (l/m AUC (µg/mlh)
English: Caelyx must not be given by the intramuscular or subcutaneous route (see section 6.6).
Croatian: Caelyx se ne smije davati intramuskularnim ili supkutanim putem (vidjeti dio 6.6).
English: Avoid intervals shorter than 10 days as medicinal product accumulation and increased toxicity cannot be ruled out.
Croatian: Izbjegavajte intervale kraće od 10 dana, jer se u tom slučaju ne može isključiti nakupljanje lijeka i povećana toksičnost.
English: Do not use Caelyx - if you are allergic to doxorubicin hydrochloride, peanut or soya, or any of the ingredients of this medicine (listed in section 6).
Croatian: Nemojte primjenjivati Caelyx - ako ste alergični na doksorubicinklorid, kikiriki ili soju ili neki sastojak ovog lijeka (naveden u dijelu 6.).
English: Grade 3 or 4 non-haematologic medicine related toxicity
Croatian: 3. ili 4. stupanj nehematološke toksičnosti povezane s lijekom
English: The range of Billingham cardiotoxicity scores was grades 0-1.5.
Croatian: Prema Billinghamovoj ljestvici bodovanja kardiotoksičnost je bila stupnja 0 - 1,5.
English: These methods must be applied routinely before the initiation of Caelyx therapy and repeated periodically during treatment.
Croatian: Ovi se postupci moraju rutinski primijeniti prije početka liječenja Caelyxom i redovito ponavljati tijekom liječenja.
English: A similar incidence of infusion reactions (12.4%) and treatment discontinuation (1.5%) was observed in the breast cancer program.
Croatian: Slična incidencija reakcija na infuziju (12,4%) i prekida liječenja (1,5%) primijećena je u programu liječenja karcinoma dojke.
English: Haematological toxicity may require dose reduction or suspension or delay of therapy.
Croatian: Zbog hematološke toksičnosti može biti potrebno smanjiti dozu ili prekinuti ili odgoditi terapiju.
English: Very rarely, convulsions also have been observed in relation to infusion reactions (see section 4.8).
Croatian: Vrlo rijetko primijećene su i konvulzije povezane s reakcijama na infuziju (vidjeti dio 4.8).
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C.
Croatian: Ako se ne primijeni odmah, vrijeme i uvjeti čuvanja pripremljenog lijeka odgovornost su korisnika, a lijek se ne smije držati dulje od 24 sata na temperaturi od 2 °C do 8 °C.
English: Following marketing, bullous eruption has been reported rarely in this population.
Croatian: Nakon stavljanja lijeka u promet, u ove je populacije rijetko bila uočena bulozna erupcija.
English: In this case, the dose interval may be extended by 1-2 weeks or the dose reduced (see section 4.2).
Croatian: U tom se slučaju razmak između doza može produljiti za 1 - 2 tjedna ili se može smanjiti doza (vidjeti dio 4.2).
English: Population based analysis demonstrates that age across the range tested (21-75 years) does not significantly alter the pharmacokinetics of Caelyx.
Croatian: Populacijska analiza pokazuje da dob u ispitivanom rasponu (21 - 75 godina) ne mijenja značajno farmakokinetiku Caelyxa.
English: The dose is repeated every 4 weeks for as long as the disease does not progress and you are able to tolerate the treatment.
Croatian: Doza se ponavlja svaka 4 tjedna sve dok nema napredovanja bolesti i dok Vi dobro podnosite liječenje.
English: Store in a refrigerator (2C - 8C).
Croatian: Čuvati u hladnjaku (2 C - 8 C).
English: Other medicines and Caelyx Tell your doctor or pharmacist - if you are taking or have recently taken any other medicines, including medicines obtained without a prescription; - about any other cancer treatments you are on or have been taking, as particular care needs to be taken with treatments which reduce the number of white blood cells, as this may cause further reduction in the number of white blood cells.
Croatian: Drugi lijekovi i Caelyx Obavijestite svog liječnika ili ljekarnika - ako uzimate, nedavno ste uzeli bilo koje druge lijekove, uključujući i one koje ste nabavili bez recepta; - o svakom drugom lijeku za liječenje raka koji uzimate ili ste uzimali, zato što je potreban osobit oprez kad se radi o lijekovima koji smanjuju broj bijelih krvnih stanica jer ovaj lijek može prouzročiti daljnje smanjenje broja bijelih krvnih stanica.
English: Caelyx has no or negligible influence on the ability to drive and use machines.
Croatian: Caelyx ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: What Caelyx is and what it is used for What you need to know before you use Caelyx How to use Caelyx
Croatian: Što je Caelyx i za što se koristi Što morate znati prije nego počnete primjenjivati Caelyx Kako primjenjivati Caelyx
English: The frequency of lichenoid keratosis was determined as “rare” based on clinical trials.
Croatian: Učestalost lihenoidne keratoze određena je kao "rijetka" na temelju kliničkih ispitivanja.
English: Avoid becoming pregnant while you or your partner are taking Caelyx and in the six months following discontinuation of Caelyx treatment.
Croatian: Izbjegavajte trudnoću dok Vi ili Vaš partner uzimate Caelyx, kao i tijekom šest mjeseci nakon prestanka liječenja Caelyxom.
English: Caution must be observed in patients who have received other anthracyclines.
Croatian: Potreban je oprez u bolesnika koji su primali druge antracikline.
English: The reported incidence of life-threatening (grade 4) cases was < 1%.
Croatian: Zabilježena incidencija životno opasnih slučajeva (stupanj 4) bila je < 1%.
English: What Caelyx is and what it is used for
Croatian: Što je Caelyx i za što se koristi
English: These effects were mostly mild, with severe (grade 3) cases reported in 17%-19.5%.
Croatian: PPE je većinom bio blag, s time da su teški slučajevi (stupanj 3) zabilježeni u 17% - 19,5%.
English: Although the biological mechanism of lichenoid keratosis after doxorubicin is not known, the PRAC considers that “lichenoid keratosis” should be included as a new adverse drug reaction in section 4.8 of the SmPC based on the review of the cases.
Croatian: Iako biološki mehanizam lihenoidne keratoze nakon primjene doksorubicina nije poznat, PRAC smatra da bi se “lihenoidna keratoza” trebala uvrstiti kao nova nuspojava u dio 4.8 SmPC-a na temelju pregleda slučajeva.
English: This is probably the result of intercalation of the anthracycline between adjacent base pairs of the DNA double helix thus preventing their unwinding for replication.
Croatian: To je vjerojatno rezultat interkalacije antraciklina između susjednih parova baza u dvostrukoj uzvojnici DNK, čime se sprječava njihovo razdvajanje kod replikacije.
English: Furthermore, based on the pooled analysis of 4,231 patients across indications, the SmPC should be updated to in order to better detail the risk of cardiotoxicity associated with Caelyx.
Croatian: Nadalje, na temelju analize objedinjenih podataka 4231 bolesnika u svim indikacijama, SmPC treba ažurirati kako bi se bolje objasnio rizik od kardiotoksičnosti povezane s Caelyxom.
English: No pharmacokinetic data are available in patients with creatinine clearance of less than 30 ml/min.
Croatian: Nema dostupnih farmakokinetičkih podataka za bolesnike s klirensom kreatinina manjim od 30 ml/min.
English: The infusion may be given through a peripheral vein.
Croatian: Infuzija se može dati kroz perifernu venu.
English: Decrease dose by 25%; return to 4 week interval or withdraw patient per physician's assessment
Croatian: Smanjiti dozu za 25%; povratak na 4tjedni interval ili prekinuti primjenu ovisno o procjeni liječnika
English: This interim analysis showed a TTP risk reduction of 45% (95% CI: 29-57%), p < 0.0001.
Croatian: Ova privremena analiza pokazala je smanjenje rizika za TTP od 45% (95% CI: 29-57%), p < 0,0001.
English: Infusion reactions rarely recur after the first treatment cycle with Caelyx (see section 4.2).
Croatian: Reakcije na infuziju rijetko se ponavljaju nakon prvog ciklusa liječenja Caelyxom (vidjeti dio 4.2).
English: Exercise caution in patients with impaired cardiac function who receive Caelyx.
Croatian: Budite oprezni kod bolesnika s oštećenom srčanom funkcijom koji primaju Caelyx.
English: Grades 3/4** n=318
Croatian: Stupanj 3/4** n=318
English: Growth factor support was required infrequently (< 5%) and transfusion support was required in approximately 15% of patients (see section 4.2).
Croatian: Potpora čimbenikom rasta nije bila često potrebna (< 5%), dok je potpora transfuzijom bila potrebna u približno 15% bolesnica (vidjeti dio 4.2).
English: In the breast cancer trial program, modification of the infusion was permitted for those patients experiencing an infusion reaction as follows: 5% of the total dose was infused slowly over the first 15 minutes.
Croatian: U ispitivanom programu liječenja raka dojke, prilagodba infuzije bila je dopuštena za one bolesnice koje su imale reakcije na infuziju i to na sljedeći način: 5% ukupne doze dano je infuzijom polako tijekom prvih 15 minuta.
English: The bortezomib regimen consists of 1.3 mg/m² on days 1, 4, 8, and 11 every 3 weeks.
Croatian: Protokol s bortezomibom sastoji se od primjene 1,3 mg/m² bortezomiba 1., 4., 8. i 11. dan svaka 3 tjedna.
English: For further instructions on preparation and special precautions for handling see section 6.6.
Croatian: Za daljnje upute za pripremu i posebne mjere za rukovanje lijekom vidjeti dio 6.6.
English: 1 half-life (hours)
Croatian: 1 poluvijek (sati)
English: These linear MPEG groups extend from the liposome surface creating a protective coating that reduces interactions between the lipid bilayer membrane and the plasma components.
Croatian: Ove linearne skupine MPEG-a pružaju se s površine liposoma, stvarajući zaštitni omotač koji smanjuje interakcije između dvoslojne lipidne membrane i komponenata plazme.
English: Very rarely, convulsions have been observed in relation to infusion reactions.
Croatian: Vrlo su rijetko su bile uočene konvulzije povezane s reakcijom na infuziju.
English: PPE is characterised by painful, macular reddening skin eruptions.
Croatian: PPE karakteriziraju bolne, makularne erupcije po koži.
English: Only 13 of these 88 patients (15%) had at least one clinically significant change in their LVEF, defined as an LVEF value less than 45% or a decrease of at least 20 points from baseline.
Croatian: Samo je 13 od ovih 88 bolesnika (15%) imalo najmanje jednu klinički značajnu promjenu u LVEF nalazu, koja je definirana kao vrijednost LVEF manja od 45% ili smanjenje LVEF za najmanje 20 bodova u odnosu na početno stanje.
English: Take the appropriate volume of Caelyx up into a sterile syringe.
Croatian: Izvucite odgovarajući volumen Caelyxa u sterilnu štrcaljku.
English: It is generally believed that inhibition of DNA, RNA and protein synthesis is responsible for the majority of the cytotoxic effects.
Croatian: Općenito se vjeruje da je inhibicija sinteze DNK, RNK i sinteze bjelančevina odgovorna za većinu citotoksičnih učinaka.
English: The dosage can be increased to full dose for subsequent cycles if tolerated.
Croatian: Dozu je moguće povećati do pune doze u sljedećim ciklusima ukoliko se lijek dobro podnosi.
English: In the study in dogs, the occurrence and severity of these lesions was reduced by lowering the dose or prolonging the intervals between doses.
Croatian: U ispitivanju na psima, nastanak i težina tih lezija smanjili su se sniženjem doze ili produljenjem razmaka između primjene doza.
English: Wait until ANC  1,500 and platelets  75,000; decrease dose by 25% or continue full dose with growth factor support.
Croatian: Pričekati dok ANC bude  1500 i trombociti  75 000; smanjiti dozu za 25% ili nastaviti punom dozom uz potporu čimbenikom rasta.
English: Increases in AST were less frequently (< 1%) reported.
Croatian: Povećanje razine AST bilo je manje često (< 1%).
English: Health experts recommend that HIV infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.
Croatian: Liječnici preporučuju ženama inficiranima HIV-om da ne doje svoju djecu ni pod kojim okolnostima kako bi izbjegle prijenos HIV-a.
English: The incidence of life threatening (grade 4) haematologic effects was < 1.0% and sepsis was reported in 1% of patients.
Croatian: Incidencija životno opasnih (stupanj 4) hematoloških posljedica bila je < 1,0%, a sepsa je zabilježena u 1% bolesnika.
English: ** Grade 3/4 adverse events are based on the adverse event terms of all severities with an overall incidence ≥ 5% (see adverse events listed in first column).
Croatian: ** Nuspojave 3./4. stupnja temelje se na uvjetima za nuspojave svih stupnjeva težine uz ukupnu incidenciju ≥ 5% (vidjeti popis nuspojava u prvom stupcu).
English: To manage adverse events such as palmar-plantar erythrodysesthesia (PPE), stomatitis or haematological toxicity, the dose may be reduced or delayed.
Croatian: Zbog liječenja nuspojava kao što su palmarno-plantarna eritrodizestezija (PPE), stomatitis ili hematološka toksičnost, dozu je moguće smanjiti ili odgoditi primjenu lijeka.
English: If the patient tolerates the first dose without an increase in serum bilirubin or liver enzymes, the dose for cycle 2 can be increased to the next dose level, i.e., if reduced by 25% for the first dose, increase to full dose for cycle 2; if reduced by 50% for the first dose, increase to 75% of full dose for cycle 2.
Croatian: Ako bolesnik podnese prvu dozu bez povećanja razine serumskog bilirubina ili vrijednosti jetrenih enzima, doza se u 2. ciklusu može povećati na sljedeću višu razinu, tj. ako je prva doza bila smanjena za 25%, povećajte je na punu dozu u 2. ciklusu; ako je prva doza bila smanjena za 50%, povećajte je na 75% pune doze u 2. ciklusu.
English: Transient ECG changes such as T-wave flattening, S-T segment depression and benign arrhythmias are not considered mandatory indications for the suspension of Caelyx therapy.
Croatian: Prolazne promjene u EKG nalazu, kao što su izravnavanje T-vala, depresija S-T segmenta i benigne aritmije, ne smatraju se obaveznim indikacijama za prekid liječenja Caelyxom.
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the RMP presented in Module 1.8.2. of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: Myelosuppression was mostly mild or moderate and manageable.
Croatian: Mijelosupresija je uglavnom bila blaga do umjerena i lako liječiva.
English: Furthermore, only 1 patient (cumulative anthracycline dose of 944 mg/m2), discontinued study treatment because of clinical symptoms of congestive heart failure.
Croatian: Nadalje, samo je u jednog bolesnika (kumulativna doza antraciklina od 944 mg/m2) prekinuto ispitivano liječenje zbog kliničkih simptoma kongestivnog zatajenja srca.
English: Pharmacotherapeutic group: Cytotoxic agents (anthracyclines and related substances), ATC code: L01DB01.
Croatian: Farmakoterapijska skupina: citotoksični antibiotici (antraciklini i slični pripravci), ATK oznaka: L01DB01.
English: PPE*, rash
Croatian: PPE*, osip
English: Grade 3 (blistering, ulceration, or swelling interfering with walking or normal daily activities; cannot wear regular clothing)
Croatian: 3. stupanj (nastanak mjehurića, ulceracija ili oticanje koji ometaju hodanje ili normalne svakodnevne aktivnosti; ne može nositi uobičajenu odjeću)
English: This can be infused over 60 or 90 minutes as detailed in 4.2.
Croatian: Doza se može primijeniti infuzijom u trajanju od 60 ili 90 minuta, kako je opisano u dijelu 4.2.
English: Patients should be examined at regular intervals for the presence of oral ulceration or any oral discomfort that may be indicative of secondary oral cancer.
Croatian: Bolesnici se moraju pregledavati u redovitim intervalima na prisutnost ulceracija u ustima ili bilo koje nelagode u ustima koja bi mogla ukazivati na sekundarni karcinom usta.
English: Taking into account the PRAC Assessment Report on the PSUR(s) for doxorubicin, the scientific conclusions of the CHMP are as follows:
Croatian: Uzimajući u obzir PRAC-ovo izvješće o ocjeni periodičkog(ih) izvješća o neškodljivosti lijeka (PSUR) za doksorubicin, znanstveni zaključci su sljedeći:
English: Other less frequently (< 5%) observed undesirable effects included hypersensitivity reactions including anaphylactic reactions.
Croatian: Druge manje česte (< 5%) nuspojave bile su reakcije preosjetljivosti uključujući anafilaktičku reakciju.
English: PPE appears to be primarily related to the dose schedule and can be reduced by extending the dose interval 1-2 weeks (see section 4.2).
Croatian: Čini se da je PPE primarno povezan s rasporedom doza i može se ublažiti produljenjem intervala između doza za 12 tjedna (vidjeti dio 4.2).
English: Based on the review of the safety data of pegylated liposomal doxorubicin hydrochloride (Caelyx), a signal of lichenoid keratosis was detected with a total of 10 cases reported.
Croatian: Na temelju pregleda podataka o sigurnosti za pegilirani liposomalni doksorubicinklorid (Caelyx), otkriven je signal lihenoidne keratoze s ukupno 10 prijavljenih slučajeva.
English: Grade 2 (erythema, desquamation, or swelling interfering with, but not precluding normal physical activities; small blisters or ulcerations less than 2 cm in diameter)
Croatian: 2. stupanj (eritem, ljuštenje ili oticanje koji ometaju, ali ne sprječavaju normalne fizičke aktivnosti; mjehurići ili ulceracije promjera manjeg od 2 cm)
English: Caelyx must not be used to treat AIDS-KS that may be treated effectively with local therapy or systemic alfa-interferon.
Croatian: Caelyx se ne smije primjenjivati za liječenje Kaposijevog sarkoma povezanog s AIDS-om koji se može učinkovito liječiti lokalnom terapijom ili sistemskim alfa-interferonom.
English: Treatment discontinuation of one or both agents due to adverse events was seen in 38% of patients.
Croatian: Liječenje s jednim ili oba lijeka moralo se prekinuti zbog nuspojava u 38% bolesnika.
English: - From a microbiological point of view, the product should be used immediately.
Croatian: - S mikrobiološkog stajališta, lijek se mora odmah primijeniti.
English: Because the active ingredient doxorubicin hydrochloride in Caelyx may cause birth defects, it is important to tell your doctor if you think you are pregnant.
Croatian: Budući da djelatna tvar doksorubicinklorid u Caelyxu može prouzročiti urođene mane, važno je da obavijestite liječnika ako mislite da ste trudni.
English: Some of these effects may be related to your disease and not to Caelyx; - general feeling of tiredness, weakness, feeling of pins and needles or pain in hands and feet; - hair loss.
Croatian: Neki od navedenih učinaka mogu biti povezani s Vašom bolešću, a ne s Caelyxom; - opći osjećaj umora, slabost, osjećaj trnaca i mravaca ili bolovi u šakama i stopalima; - ispadanje kose
English: Pegylated liposomes are small enough (average diameter of approximately 100 nm) to pass intact (extravasate) through defective blood vessels supplying tumours.
Croatian: Pegilirani liposomi dovoljno su mali (prosječni promjer od približno 100 nm) da neoštećeni prođu (ekstravazacija) kroz krhke krvne žile koje opskrbljuju tumor.
English: Turnhoutseweg 30 B-2340 Beerse Belgium
Croatian: Turnhoutseweg 30 B-2340 Beerse Belgija
English: Caelyx will be given to you by your doctor in a drip (infusion) into a vein.
Croatian: Caelyx će Vam davati liječnik putem dripa (infuzije) u venu.
English: Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium
Croatian: Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgija
English: However, medications to treat these symptoms (e.g., antihistamines, corticosteroids, adrenaline, and anticonvulsants), as well as emergency equipment should be available for immediate use.
Croatian: Međutim, pri ruci treba imati lijekove za hitno liječenje ovih simptoma (npr. antihistaminike, kortikosteroide, adrenalin i antikonvulzive), kao i opremu za pružanje hitne pomoći.
English: Do not dose; if 2 or more doses are not given in a cycle, reduce dose by 25% in following cycles.
Croatian: Nemojte primijeniti dozu; ako 2 ili više doza tijekom jednog ciklusa nisu primjenjene, smanjite dozu za 25% u sljedećim ciklusima.
English: Temporarily suspend Caelyx treatment in patients when the ANC count is < 1,000/mm
Croatian: Privremeno prekinite liječenje bolesnika Caelyxom kad im je ANC < 1.000/mm
English: Pregnancy and breast-feeding Ask your doctor or pharmacist for advice before taking any medicine.
Croatian: Obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete bilo koji lijek.
English: However, in clinical studies to date, dizziness and somnolence were associated infrequently (< 5%) with the administration of Caelyx.
Croatian: Međutim, u do sada provedenim kliničkim ispitivanjima omaglica i pospanost nisu bile često povezane (< 5%) s primjenom lijeka Caelyx.
English: Local toxicity
Croatian: Lokalna toksičnost
English: It is used to kill cancer cells, shrink the size of the tumour, delay the growth of the tumour, and extend your survival.
Croatian: Primjenjuje se za uništavanje stanica raka, smanjenje veličine tumora, usporavanje rasta tumora i produljenje života.
English: Because many medicinal products, including anthracyclines, are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants, therefore mothers must discontinue nursing prior to beginning Caelyx treatment.
Croatian: Zbog toga što se mnogi lijekovi, uključujući antracikline, izlučuju u majčino mlijeko i zbog mogućnosti ozbiljnih nuspojava u dojene djece, majke moraju prekinuti dojenje prije početka liječenja Caelyxom.
English: Temporarily stopping the infusion usually resolves these symptoms without further therapy.
Croatian: Privremeni prekid infuzije obično dovodi do povlačenja ovih simptoma bez daljnjeg liječenja.
English: What you need to know before you use Caelyx
Croatian: Što morate znati prije nego počnete primjenjivati Caelyx
English: 2 half-life (hours)
Croatian: 2 poluvijek (sati)
English: The evaluation of left ventricular function is considered to be mandatory before each additional administration of Caelyx that exceeds a lifetime cumulative anthracycline dose of 450 mg/m
Croatian: Procjena funkcije lijeve klijetke smatra se obvezatnom prije svake primjene Caelyxa koja premašuje doživotnu kumulativnu dozu antraciklina od 450 mg/m
English: These grading scores are consistent with no or mild cardiac toxicity.
Croatian: Ovi stupnjevi odgovaraju stanju odsutnosti srčane toksičnosti ili blage srčane toksičnosti.
English: When Caelyx is used alone, some of these effects are less likely to occur, and some have not occurred at all.
Croatian: Kada se Caelyx primjenjuje u monoterapiji, vjerojatnost pojave nekih ovih učinaka je manja, a neki se uopće ne javljaju.
English: The apparent half-life ranged from 24-231 hours, with a mean of 73.9 hours.
Croatian: Prividni poluvijek kretao se u rasponu 24 - 231 sat, uz prosjek od 73,9 sati.