FrancophonIA/ELRC3.0 huggingface dataset:
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Adcirca.
Slovenian: Pojasnjuje, kako je Odbor za zdravila za uporabo v humani medicini (CHMP) ocenil to zdravilo, na podlagi česar je oblikoval mnenje za izdajo dovoljenja za promet z njim in priporočila glede pogojev njegove uporabe.
English: Adcirca is not recommended for patients with severe kidney or liver problems.
Slovenian: Zdravilo Adcirca ni priporočeno za bolnike z resnimi težavami z ledvicami ali jetri.
English: Adcirca is used to treat adults with pulmonary arterial hypertension (PAH) to improve exercise capacity (the ability to carry out physical activity).
Slovenian: Zdravilo Adcirca se uporablja za zdravljenje odraslih bolnikov s pljučno arterijsko hipertenzijo (PAH) za izboljšanje telesne zmogljivosti (sposobnosti izvajanja telesne dejavnosti).
English: Why has Adcirca been approved?
Slovenian: Zakaj je bilo zdravilo Adcirca odobreno?
English: The active substance in Adcirca, tadalafil, belongs to a group of medicines called ‘phosphodiesterase type 5 (PDE5) inhibitors', which means that it blocks the PDE5 enzyme.
Slovenian: Zdravilna učinkovina v zdravilu Adcirca, tadalafil, spada v skupino zdravil, imenovanih zaviralci fosfodiesteraze tipa 5 (PDE5), kar pomeni, da zavira encim PDE5.
English: Adcirca must not be used in patients who have had an acute myocardial infarction (sudden heart attack) within the last three months, or who have severe hypotension (low blood pressure).
Slovenian: Zdravilo se ne sme se uporabljati pri bolnikih, ki so v zadnjih treh mesecih doživeli akutni miokardni infarkt (nenaden srčni napad) ali ki imajo hudo hipotenzijo (nizek krvni tlak).
English: This pressure reduces the amount of oxygen that can get into the blood in the lungs, making physical activity more difficult.
Slovenian: Povečan tlak zniža količino kisika, ki lahko pride v kri v pljučih, zaradi česar je telesna dejavnost otežena.
English: Patients with mild or moderate kidney or liver problems should start with a lower dose, but this can be increased if
Slovenian: Bolniki z blagimi ali zmernimi težavami z ledvicami ali jetri naj začnejo zdravljenje z nižjim odmerkom, ki pa se po
English: Adcirca treatment should only be started and monitored by a doctor who has experience in the treatment of PAH.
Slovenian: Zdravljenje z zdravilom Adcirca sme uvesti in nadzorovati le zdravnik, ki ima izkušnje z zdravljenjem pljučne arterijske hipertenzije.
English: Adcirca must not be taken with nitrates (a group of medicines used to treat angina) or medicines of the class ‘guanylate cyclase stimulators' such as riociguat (another medicine to treat pulmonary hypertension).
Slovenian: Zdravilo Adcirca se ne sme jemati z nitrati (skupino zdravil za zdravljenje angine pektoris) ali z zdravili razreda spodbujevalcev gvanilat ciklaze, kot je riocigvat (drugo zdravilo za zdravljenje pljučne hipertenzije).
English: For the full list of all side effects and restrictions with Adcirca, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov in omejitev pri uporabi zdravila Adcirca glejte navodilo za uporabo.
English: Four doses of Adcirca (2.5, 10, 20 and 40 mg once a day) have been compared with placebo (a dummy treatment) in one main study involving 406 patients with PAH, most of whom had class II or class III disease that was of unknown cause or caused by collagen vascular disease.
Slovenian: Štiri odmerke zdravila Adcirca (2,5, 10, 20 in 40 mg enkrat na dan) so primerjali s placebom (zdravilom brez zdravilne učinkovine) v eni glavni študiji, v katero je bilo vključenih 406 bolnikov s pljučno arterijsko hipertenzijo.
English: It must not be used in patients who have ever had loss of vision because of a problem called nonarteritic anterior ischaemic optic neuropathy (NAION) that affects the blood flow to the nerve in the eye.
Slovenian: Zdravilo se ne sme uporabljati pri bolnikih, ki so v preteklosti izgubili vid zaradi nearteritične anteriorne ishemične optične nevropatije (NAION), ki vpliva na dotok krvi v očesni živec.
English: In patients with PAH, Adcirca widens the blood vessels of the lungs, which lowers the blood pressure and improves symptoms.
Slovenian: Pri bolnikih s pljučno arterijsko hipertenzijo zdravilo Adcirca razširi krvne žile v pljučih, kar zmanjša krvni tlak in izboljša simptome.
English: Adcirca has been shown to be effective in PAH with no identified cause and in PAH caused by collagen vascular disease.
Slovenian: Zdravilo Adcirca se je izkazalo za učinkovito pri pljučni hipertenziji brez opredeljenega vzroka in pri pljučni hipertenziji, katere vzrok je sistemska bolezen veziva.
English: It causes high blood pressure in the vessels taking blood from the heart to the lungs.
Slovenian: To povzroči zelo visok krvni tlak v žilah, po katerih se kri pretaka iz srca v pljuča.
English: How has Adcirca been studied?
Slovenian: Kako je bilo zdravilo Adcirca raziskano?
English: What is Adcirca used for?
Slovenian: Za kaj se zdravilo Adcirca uporablja?
English: How is Adcirca used?
Slovenian: Kako se zdravilo Adcirca uporablja?
English: What is Adcirca?
Slovenian: Kaj je zdravilo Adcirca?
English: How does Adcirca work?
Slovenian: Kako zdravilo Adcirca deluje?
English: Under these conditions the ability to react may be decreased.
Slovenian: V takih pogojih je zmožnost reagiranja lahko zmanjšana.
English: Rare (0.01-0.1%)
Slovenian: Redki (0,01-0,1 %)
English: Common (>1%)
Slovenian: Pogosti (> 1 %)
English: This should be taken into account when driving or using machines.
Slovenian: Pri vožnji in uporabi strojev je treba to upoštevati.
English: Titanium dioxide (E 171)
Slovenian: Titanov dioksid (E 171)
English: (see section 4.8 Undesirable effects).
Slovenian: (glejte poglavje 4.8 Neželeni učinki).
English: Aluminium/Aluminium blister (Alu/OPA/PVC/PE)
Slovenian: Pretisni omot iz aluminija/aluminija (Alu/OPA/PVC/PE)
English: However, in order to avoid treatment failure, local antibacterial resistance patterns and local guidelines should be considered.
Slovenian: Za preprečitev neuspešnega zdravljenja je treba upoštevati lokalne vzorce antibakterijske rezistence in lokalne smernice.
English: Consideration should be given to official local guidance (e.g. national recommendations) regarding bacterial resistance and the appropriate use and prescription of antibacterial agents.
Slovenian: Bodite pozorni na uradne smernice (npr. državna priporočila) glede bakterijske rezistence in ustrezne uporabe ter predpisovanja antibakterijskih sredstev.
English: Each hard capsule contains 15 or 30 mg lansoprazole.
Slovenian: Vsaka trda kapsula vsebuje 15 ali 30 mg lansoprazola.
English: The capsules may be emptied, but the contents may not be chewed or ground.
Slovenian: Kapsule se lahko izpraznijo, vendar se njihove vsebine ne sme žvečiti ali zdrobiti.
English: dry mouth or throat,
Slovenian: suha usta ali žrelo,
English: Because of limited safety data for patients on maintenance treatment for longer than 1 year, regular review of the treatment and a thorough benefit risk assessment should regularly be performed in these patients (see “5.3 Preclinical safety data”).
Slovenian: Zaradi omejenih podatkov o varnosti bolnikov na vzdrževalnem zdravljenju, ki traja dlje kot eno leto, je treba redno ocenjevati zdravljenje in opraviti temeljito oceno tveganja in koristi (glejte 5.3 Predklinični podatki o varnosti).
English: Interaction with Other Medicinal Products and Other Forms of Interaction
Slovenian: 4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij
English: 7, 10, 14, 15, 20, 28, 30, 35, 50, 56, 60, 84, 98, 100 and 250 capsules
Slovenian: 7, 10, 14, 15, 20, 28, 30, 35, 50, 56, 60, 84, 98, 100 in 250 kapsul
English: If visual disturbances occur during long-term use (>1 year), an ophthalmologist should be consulted.
Slovenian: Če se pri dolgotrajni uporabi (> 1 leto) pojavijo motnje vida, se je treba posvetovati z okulistom.
English: 2, 7, 10, 14, 15, 20, 28, 30, 35, 42, 50, 56, 60, 98, 100 and 250 capsules
Slovenian: 2, 7, 10, 14, 15, 20, 28, 30, 35, 42, 50, 56, 60, 98, 100 in 250 kapsul
English: Bioavailability after a single dose of 30 mg and after repeated daily administration is 80-90%.
Slovenian: Biološka razpoložljivost po enkratnem 30-miligramskem odmerku in po ponavljajoči se dnevni uporabi je 80-90 %.
English: The dose should be individually adjusted and the treatment should be continued for as long as necessary.
Slovenian: Odmerek je treba prilagoditi vsakemu bolniku posebej in zdravljenje nadaljevati, dokler je potrebno.
English: 15 mg once daily.
Slovenian: 15 mg enkrat dnevno.
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTE OF ADMINISTRATION, APPLICANT, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
Slovenian: DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, NAČINOV UPORABE ZDRAVILA, VLAGATELJEV, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
English: Eradication of Helicobacter pylori:
Slovenian: Eradikacija Helicobacter pylori:
English: Preliminary data suggest that lansoprazole-based eradication therapy is effective in children and the elderly.
Slovenian: Predhodni podatki nakazujejo, da je eradikacijsko zdravljenje na osnovi lansoprazola učinkovito pri otrocih in starostnikih.
English: Lansoprazole is not recommended in children as safety and efficacy have not been established in this population.
Slovenian: Uporabo lansoprazola pri otrocih odsvetujemo, saj njegova varnost in učinkovitost v tej populaciji še ni ugotovljena.
English: Undesirable Effects
Slovenian: Neželeni učinki).
English: Elderly: Due to delayed elimination of lansoprazole in the elderly it may be necessary to administer the treatment in doses of 15-30 mg adjusted to individual requirements.
Slovenian: Starejše osebe: Zaradi podaljšanega izločanja lansoprazola, bo pri starejših osebah morda treba zdravljenje razdeliti v odmerke po 15-30 mg, glede na potrebe posameznika.
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Slovenian: Bolniki z redkimi podedovanimi težavami z netoleranco za fruktozo, okvarjeno absorpcijo glukoze in galaktoze ali pomanjkanjem sukraze-izomaltaze ne smejo jemati tega zdravila.
English: Intake of food slows the absorption rate of lansoprazole and reduces its bioavailability (AUC) by about 25%.
Slovenian: Uživanje hrane upočasni absorpcijo lansoprazola in zmanjša biološko razpoložljivost (AUC) za približno 25 %.
English: 30 mg lansoprazole 2 times daily for one week in combination with one of the following three combinations:
Slovenian: 30 mg lansoprazola dvakrat dnevno v trajanju enega tedna v kombinaciji z eno od treh navedenih kombinacij:
English: Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development,
Slovenian: Študije na živalih ne kažejo neposrednih ali posrednih škodljivih vplivov na nosečnost, razvoj zarodka/plodu, porod ali postnatalni razvoj.
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with lansoprazole should be made taking into account the benefit of breast feeding to the child and the benefit of lansoprazole therapy to the woman.
Slovenian: Pri odločitvi, ali nadaljevati ali prekiniti dojenje oziroma ali nadaljevati ali prekiniti zdravljenje z lansoprazolom, je treba upoštevati korist dojenja za otroka in korist zdravljenja z lansoprazolom za žensko.
English: ANNEX III AMENDED SUMMARY OF PRODUCT CHARACTERISTICS OF THE REFERENCE MEMBER STATE
Slovenian: DODATEK III SPREMENJEN POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA REFERENČNE DRŽAVE ČLANICE
English: CYP2C19 is subject to genetic polymorphism and 2-6% of the population, called poor metabolisers (PMs), are homozygote for a mutant CYP2C19 allele and therefore lacks a functional CYP2C19 enzyme.
Slovenian: CYP2C19 je izpostavljen genetskemu polimorfizmu in 2-6 % populacije, t. i. slabi presnavljalci (PM - Poor Metaboliser), so homozigoti za mutantni alel CYP2C19, in zato nimajo funkcionalnega encima CYP2C19.
English: Reflux oesophagitis may not present as ulceration and/or visual damage, therefore in certain cases endoscopy alone may not be sufficient.
Slovenian: Refluksni ezofagitis morda ni prisoten v obliki razjede in/ali vidne poškodbe, zato v nekaterih primerih endoskopija ni zadostna.
English: Note: This SPC is the one that was Annexed to the Commission Decision on this Article 29 referral for lansoprazole containing medicinal products.
Slovenian: Opomba: Ta Povzetek glavnih značilnosti zdravila je bil priložen k odločbi Komisije v zvezi s tem postopkom, ki je bil sprožen v skladu s členom 29, za zdravila, ki vsebujejo lansoprazol.
English: Very Rare
Slovenian: Zelo redki (<
English: Pharmacotherapeutic group: Proton pump inhibitors, ATC code: A02BC03.
Slovenian: Farmakoterapevtska skupina: Zaviralci protonske črpalke, oznaka ATC: A02BC03.
English: The plasma protein binding of lansoprazole is about 95%, but this has not been found to have a significant effect on other protein bound drugs.
Slovenian: Vezava lansoprazola na beljakovine v plazmi je približno 95-odstotna, vendar to ne vpliva na druga zdravila, ki se vežejo na beljakovine v plazmi.
English: It may not be excluded that lanzoprazole may affect transport via this protein giving rise to increased plasma concentrations of P-gp substrates such as digoxin.
Slovenian: Ni mogoče izključiti možnosti, da lansoprazol morda vpliva na transport prek te beljakovine in posledično poveča plazemske koncentracije substratov P-gp, kot je digoksin.
English: The risk/benefit ratio of Lansopon 15 mg, 30 mg is considered to be favourable provided that appropriate information regarding H. pylori eradication therapy are included in the SPC.
Slovenian: Razmerje med tveganji in koristmi zdravila Lansopon 15 mg, 30 mg velja za ugodno pod pogojem, da se ustrezni podatki v zvezi z eradikacijskim zdravljenjem H. pylori vključijo v Povzetek glavnih značilnosti zdravila.
English: petechia, purpura, hair loss, erythema multiforme, stevens
Slovenian: petehija, purpura, izguba las, multiformni eritem,
English: The intake of food reduces the bioavailability of lansoprazole: it is recommended to take lansoprazole before the meal.
Slovenian: Uživanje hrane zmanjša biološko razpoložljivost lansoprazola: lansoprazol je priporočeno vzeti pred obrokom.
English: palpitation and chest pain.
Slovenian: palpitacije in bolečine v prsnem košu.
English: Lansoprazole is concentrated in the parietal cells and becomes active in their acidic environment, whereupon it reacts with the sulphydryl group of H
Slovenian: Lansoprazol je koncentriran v parietalnih celicah in se aktivira v njihovem kislem okolju, kjer reagira s sulfidrilno skupino H +/K
English: The effects of other drugs on lansoprazole
Slovenian: Učinek drugih zdravil na lansoprazol
English: Endocrine disorders gynecomastia, galactorrhoea.
Slovenian: Bolezni endokrinega sistema ginekomastija, galaktoreja.
English: Concomitantly taken food slows down and reduces the absorption of lansoprazole.
Slovenian: Sočasno uživanje hrane upočasni in zmanjša absorpcijo lansoprazola.
English: *The effects of clarithromycin on the pharmacokinetics of lansoprazole are likely to be dependent on the patient's CYP2C19 genotype.
Slovenian: *Učinki klaritromicina na farmakokinetiko lansoprazola so verjetno odvisni od bolnikovega genotipa CYP2C19.
English: Johnson syndrome and toxic epidermal necrolysis.
Slovenian: Stevens-Johnsonov sindrom in toksična epidermalna nekroliza.
English: Clinically significant interactions of lansoprazole with nonsteroidal anti-inflammatory drugs or diazepam have not been demonstrated, though formal interaction studies with lansoprazole and NSAIDs have not been conducted.
Slovenian: Klinično pomembnih interakcij med lansoprazolom in nesteroidnimi protivnetnimi zdravili ali diazepamom niso opazili, vendar formalnih študij interakcij med lansoprazolom in nesteroidnimi protivnetnimi zdravili niso opravili.
English: Combinations of lansoprazole with one or two antibiotics produced equivalent eradication of H. pylori.
Slovenian: S kombinacijo lansoprazola z enim ali dvema antibiotikoma so dosegli enakovredno eradikacijo H. pylori.
English: Member State Marketing Authorisation
Slovenian: Država članica Imetnik dovoljenja za promet z zdravilom
English: Results of studies on carcinogenic potential show that lansoprazole therapy is associated with Leydig cell hyperplasia and benign Leydig cell tumours in rats.
Slovenian: Rezultati študij karcinogenega potenciala so pokazali, da je zdravljenje z lansoprazolom povezano s hiperplazijo Leydigovih celic in benignimi tumorji Leydigovih celic pri podganah.
English: The drug combination may result in increased carbamazepin concentrations as well as reduced lansoprazole concentrations.
Slovenian: Ta kombinacija zdravil lahko povzroči povečanje koncentracije karbamazepina in zmanjšanje koncentracije lansoprazola.
English: Retinal atrophy occurred not until 18 months of treatment.
Slovenian: Atrofija mrežnice se ni pojavila do 18. meseca zdravljenja.
English: OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF LANSOPON 15 MG, 30 MG, GASTRO-RESISTANT CAPSULES, HARD (see Annex I)
Slovenian: SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA LANSOPON 15 MG, 30 MG, GASTROREZISTENTNE KAPSULE, TRDE (glejte Dodatek I)
English: Liver and kidneys
Slovenian: Jetra in ledvice
English: lansoprazole +
Slovenian: lansoprazol +
English: • Eradication of Helicobacter pylori concurrently given with appropriate antibiotic therapy and prevention of relapse of peptic ulcers in patients with H. pylori associated ulcers..
Slovenian: • Eradikacija Helicobacter pylori pri sočasnem zdravljenju z ustreznimi antibiotiki in preprečevanje ponovitve želodčne razjede pri bolnikih z razjedami, povezanimi s H. pylori.
English: Lansoprazole and associated names (see Annex I), 15 mg gastro-resistant capsule, hard Lansoprazole and associated names (see Annex I), 30 mg gastro-resistant capsule, hard
Slovenian: Lansoprazol in povezana imena (glejte Dodatek I), 15 mg trde gastrorezistentne kapsule Lansoprazol in povezana imena (glejte Dodatek I), 30 mg trde gastrorezistentne kapsule
English: For excipients, see 6.1.
Slovenian: Za pomožne snovi glejte poglavje 6.1.
English: Hypersensitivity to lansoprazole or any of the excipients of the product.
Slovenian: Preobčutljivost za lansoprazol ali katero koli pomožno snov.
English: Drugs which inhibits CYP2C19
Slovenian: Zdravila, ki zavirajo CYP2C19
English: Sugar spheres (sucrose and maize starch) Sodium laurilsulphate Meglumine
Slovenian: Kroglice iz sladkorja (saharoza in koruzni škrob) Natrijev lavrilsulfat
English: The effect may also be present if lansoprazole is combined with other drugs with pH dependent absorption.
Slovenian: Ta učinek je lahko prisoten tudi, če lansoprazol kombiniramo z drugimi zdravili, katerih absorpcija je odvisna od pH. Digoksin
English: As lansoprazole is metabolised via a drug metabolising enzyme system associated with cytochrome P450 (CYP2C19 and CYP3A4), interactions with drugs metabolised via the same enzyme system are possible.
Slovenian: Zdravila, povezana s citokromom P450 Lansoprazol presnavlja encimski sistem, povezan s citokromom P450 (CYP2C19 in CYP3A4), zato so mogoče interakcije z zdravili, ki jih presnavlja isti encimski sistem.
English: Daily doses of up to 180 mg have been used.
Slovenian: Lahko se uporabljajo odmerki do 180 mg dnevno.
English: Store in the original package in order to protect from moisture.
Slovenian: Shranjujte v originalni ovojnini, zaščiteno pred vlago.
English: anaphylactic shock, general malaise
Slovenian: anafilaktični šok, splošni občutek nelagodja
English: Fourteen-day, proton pump inhibitor-based triple therapy achieves better results than 7-day schedules.
Slovenian: Štirinajstdnevno trotirno zdravljenje z zaviralcem protonske črpalke je imelo boljše rezultate kot sedemdnevno zdravljenje.
English: Special Warning and Precautions for Use The diagnosis of gastroduodenal ulcers and reflux oesophagitis should be confirmed by endoscopy or other appropriate diagnostic means.
Slovenian: 4.4 Posebna opozorila in previdnostni ukrepi Diagnozo razjede želodca ali dvanajstnika in refluksnega ezofagitisa je treba potrditi z endoskopijo ali drugo ustrezno diagnostično metodo.
English: Lansopon 15 mg, 30 mg, gastro-resistant capsules, hard were referred for arbitration according to Article 29 of Council Directive 2001/83/EC, as amended, following concerns raised by Germany during a Mutual Recognition Procedure with Finland acting as Reference Member state.
Slovenian: Zdravilo Lansopon, 15-mg, 30-mg, gastrorezistentne kapsule, trde, je bilo napoteno na arbitražni postopek v skladu s členom 29 Direktive Sveta 2001/83/ES, kakor je bila spremenjena, zaradi zadržkov,
English: Gastro-resistant capsule, hard Oral use
Slovenian: Gastrorezistentna kapsula, trda Peroralna uporaba
English: Not yet investigated lansoprazole + clarithromycin +
Slovenian: Še ni raziskano lansoprazol + klaritromicin +
English: Eradication of H. pylori has been shown to be a definitive cure for duodenum ulcer and most gastric ulcers.
Slovenian: Eradikacija H. pylori je dokazano dokončno zdravilo za razjedo na dvanajstniku in večino gastričnih razjed.
English: It has also been proven that eradication prevents ulcer recurrence without any maintenance antisecretory therapy.
Slovenian: Prav tako je dokazano, da eradikacija brez vsakega vzdrževalnega zdravljenja z zaviranjem izločanja prepreči ponovitev razjede.
English: Metabolism and elimination: The metabolism of lansoprazole is mainly catalysed by the enzyme CYP2C19.
Slovenian: Presnova in izločanje: Presnovo lansoprazola katalizira predvsem encim CYP2C19.
English: Blood thrombocytopenia, eosinophilia, pancytopenia and agranulocytosis, anemia,
Slovenian: Kri trombocitopenija, eozinofilija, pancitopenija in agranulocitoza, anemija,
English: Nervous system headache, dizziness restlessness, insomnia, drowsiness, depression, hallucination, confusion, vertigo and paresthesia, somnolence, tremor.
Slovenian: Živčevje glavobol, vrtoglavica nemir, insomnija, dremavost, depresija, halucinacije, zmedenost,
English: DATE OF FIRST AUTHORISATION / RENEWAL OF AUTHORISATION [To be completed nationally]
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET [Podatke je treba dopolniti v posameznih državah]
English: • Treatment of duodenal and gastric ulcer confirmed by endoscopy or radiography.
Slovenian: • Zdravljenje endoskopsko ali radiografsko potrjenih razjed dvanajstnika in želodca.
English: Drugs which inhibit CYP2C19 may increase the plasma concentration of lansoprazole.
Slovenian: Zdravila, ki zavirajo CYP2C19, lahko povečajo koncentracijo lansoprazola v plazmi.
English: Three metabolites have been identified in the plasma: the sulphone, 5-hydroxy lansoprazole and the sulphide.
Slovenian: V plazmi so odkrili tri presnovke: sulfon, 5-hidroksi lansoprazol in sulfid.
English: Caution should be exercised when combining lansoprazole with drugs which have a narrow therapeutic index, as the effect of lansoprazole on the metabolism of other drugs has not been extensively investigated.
Slovenian: Pri kombiniranju lansoprazola in zdravil z ozkim terapevtskim indeksom je treba biti previden, ker učinek lansoprazola na presnovo drugih zdravil še ni bil temeljito raziskan.
English: a) amoxicillin 1 g twice daily + clarithromycin 500 mg twice daily, b) clarithromycin 250 mg twice daily + metronidazole 400-500 mg twice daily, c) amoxicillin 1 g twice daily + metronidazole 400-500 mg twice daily.
Slovenian: b) klaritromicin 250 mg dvakrat dnevno + metronidazol 400-500 mg dvakrat dnevno, b) amoksicilin 1 g dvakrat dnevno + metronidazol 400-500 mg dvakrat dnevno,
English: Lansoprazol gives a 14% reduction in the plasma concentrations of theophyllin.
Slovenian: Lansoprazol zmanjša koncentracijo teofilina v plazmi za 14 %.
English: Lansoprazole may give rise to increased plasma concentrations of drugs metabolised by CYP3A4.
Slovenian: Lansoprazol lahko poveča plazemsko koncentracijo zdravil, ki jih presnavlja CYP3A4.