FrancophonIA/ELRC3.0 huggingface dataset:
English: Fampyra may have an effect on people's ability to drive or use machines, it can cause dizziness.
Croatian: Fampyra može utjecati na sposobnost ljudi da upravljaju vozilima ili da koriste strojeve, jer može uzrokovati omaglicu.
English: Fampyra contains the active substance fampridine which belongs to a group of medicines called potassium channel blockers.
Croatian: Fampyra sadrži djelatnu tvar fampridin koja pripada skupini lijekova nazvanoj blokatori kalijevih kanala.
English: Other warnings and precautions
Croatian: Druga upozorenja i mjere opreza
English: Treatment with fampridine increases seizure risk (see section 4.8).
Croatian: Liječenje fampridinom povećava rizik pojave napadaja (vidjeti dio 4.8).
English: Absolute bioavailability of Fampyra prolonged-release tablets has not been assessed, but relative bioavailability (as compared to an aqueous oral solution) is 95%.
Croatian: Apsolutna biodostupnost Fampyra tableta s produljenim oslobađanjem nije određena, ali relativna biodostupnost (u usporedbi s vodenom oralnom otopinom) je 95%.
English: Hypersensitivity to fampridine or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivost na fampridin ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: Treatment of cultured human hepatocytes with fampridine had little or no effect on induction of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2E1 or CYP3A4/5 enzyme activities.
Croatian: Dodavanje fampridina u kulturu ljudskih hepatocita nema gotovo nikakav učinak na indukciju aktivnosti enzima CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2E1 ili CYP3A4/5.
English: Fampyra should be administered with caution to patients with cardiovascular symptoms of rhythm and sinoatrial or atrioventricular conduction cardiac disorders (these effects are seen in overdose).
Croatian: Fampyru treba primjenjivati s oprezom u bolesnika s kardiovaskularnim simptomima poremećaja ritma i srčanim poremećajima sinoatrijskog ili atrioventrikularnog provođenja (ovi učinci se vide u predoziranju).
English: The European Medicines Agency has waived the obligation to submit the results of studies with Fampyra in all subsets of the paediatric population in treatment of multiple sclerosis with walking disability (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja s Fampyrom u svim podskupinama pedijatrijske populacije u liječenju multiple skleroze s nesposobnošću hodanja (vidjeti dio 4.2 za podatke o pedijatrijskoj primjeni).
English: Patients with mild renal impairment can be expected to have approximately 1.7 to 1.9 times the fampridine concentrations achieved by patients with normal renal function.
Croatian: Može se očekivati da bolesnici s blagim oštećenjem bubrežne funkcije imaju otprilike 1,7 do 1,9 puta višu koncentraciju fampridina nego bolesnici s normalnom bubrežnom funkcijom.
English: • Worsening of nerve pain in the face (trigeminal neuralgia)
Croatian: • pogoršanje boli živca lica (trigeminalna neuralgija)
English: Fampyra should be administered with caution in the presence of any factors which may lower seizure threshold.
Croatian: Fampyru treba primjenjivati s oprezom ako je prisutan bilo koji od čimbenika koji mogu sniziti prag izbijanja napadaja.
English: In reproduction toxicity studies in rats and rabbits, decreased weight and viability of foetuses and offspring were observed at maternally toxic doses.
Croatian: U ispitivanjima reproduktivne toksičnosti u štakora i kunića, opažen je gubitak tjelesne težine i sposobnosti preživljavanja fetusa i mladunčadi pri dozama toksičnim za majku.
English: Store the tablets in the original bottle in order to protect from light and moisture.
Croatian: Čuvati tablete u originalnoj boci radi zaštite od svjetlosti i vlage.
English: Study 218MS305
Croatian: Ispitivanje 218MS305
English: − because this medicine may make you feel dizzy or unsteady this may result in an increased risk of falls
Croatian: − jer ovaj lijek može uzrokovati omaglicu ili nestabilnost što može rezultirati povećanim rizikom od pada
English: For further information on seizure risk, please refer to sections 4.3 and 4.4.
Croatian: Za više informacija o riziku od napadaja, pogledajte dijelove 4.3 i 4.4.
English: Adverse responses to orally administered fampridine were rapid in onset, most often occurring within the first 2 hours post-dose.
Croatian: Nuspojave kod peroralno primijenjenog fampridina su se pojavile brzo, najčešće unutar prvih 2 sata nakon uzimanja doze.
English: Therefore, patients should use walking aids as needed.
Croatian: Stoga, bolesnici trebaju koristiti pomagala za hodanje ako im je to potrebno.
English: Placebo N = 318*
Croatian: N = 318*
English: In clinical studies low white blood cell counts were seen in 2.1% of Fampyra patients versus 1.9% of patients on placebo.
Croatian: U kliničkim je ispitivanjima opažen snižen broj bijelih krvnih stanica u 2,1% bolesnika liječenih Fampyrom naspram 1,9% bolesnika koji su primali placebo.
English: The Fampyra prolonged-release tablet has a delay in the absorption of fampridine manifested by slower rise to a lower peak concentration, without any effect on the extent of absorption.
Croatian: Fampyra tableta s produljenim oslobađanjem ima kašnjenje u apsorpciji fampridina što se odražava kao polaganiji porast do niže vršne koncentracije, bez učinka na opseg apsorpcije.
English: Statistically and clinically meaningful improvements in walking were seen, as measured by the 12item Multiple Sclerosis Walking Scale.
Croatian: Statistički i klinički značajno poboljšanje hodanja je opaženo i mjereno 12-stupanjskom ljestvicom hodanja kod multiple skleroze.
English: Within each frequency grouping, adverse reactions are presented in the order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti, nuspojave su poredane prema opadanju stupnja ozbiljnosti.
English: What you need to know before you take Fampyra Do not take Fampyra
Croatian: Što morate znati prije nego počnete uzimati Fampyru
English: Particular attention should be given to patients with a previous history of allergic reactions.
Croatian: Naročitu pozornost treba posvetiti bolesnicima s alergijskim reakcijama u anamnezi.
English: Store the tablets in the original packaging in order to protect from light and moisture.
Croatian: Čuvati tablete u originalnom pakiranju radi zaštite od svjetlosti i vlage.
English: Fampyra is a medicine used to improve walking in adults (18 years and over) with Multiple Sclerosis (MS) related walking disability.
Croatian: Fampyra je lijek koji se koristi za poboljšanje hodanja u odraslih (18 ili više godina) s nesposobnošću hodanja povezanom s multiplom sklerozom (MS).
English: In overdose you may notice sweating, minor shaking (tremor), confusion, memory loss (amnesia) and fits (seizure).
Croatian: U predoziranju, možete opaziti znojenje, nevoljno drhtanje (tremor), konfuziju, gubitak pamćenja (amnezija) i epileptički napadaj (konvulzije).
English: There is no evidence of clinically relevant accumulation of fampridine taken at the recommended dose in patients with full renal function.
Croatian: Ne postoje dokazi o klinički relevantnom nakupljanju fampridina uzetog u preporučenoj dozi u bolesnika s normalnom bubrežnom funkcijom.
English: Missed Dose
Croatian: Propuštena doza
English: Fampridine is eliminated primarily by the kidneys as unchanged medicinal product and therefore renal function should be checked in patients where renal function might be compromised.
Croatian: Fampridin se primarno eliminira preko bubrega kao nepromijenjen lijek i prema tome se funkcija bubrega mora provjeravati u bolesnika u kojih bi funkcija bubrega mogla biti ugrožena.
English: Fampyra should not be administered more frequently or at higher doses than recommended (see section 4.4).
Croatian: Fampyra se ne smije primjenjivati učestalije ili u dozama višim od preporučenih (vidjeti dio 4.4).
English: How to take Fampyra
Croatian: Kako uzimati Fampyru
English: In animal studies no effects on fertility were seen.
Croatian: Nisu opaženi učinci na plodnost u ispitivanjima na životinjama.
English: Foil blisters (aluminium / aluminium), each blister tray contains 14 tablets.
Croatian: Blisteri od folije (aluminij / aluminij), svaka blister traka sadrži 14 tableta.
English: If you are pregnant, or are planning to become pregnant, tell your doctor before you take Fampyra Fampyra is not recommended during pregnancy.
Croatian: Ako ste trudni, ili planirate imati dijete, obratite se svom liječniku za savjet prije nego uzmete Fampyru.
English: Repeated seizure activity should be treated with benzodiazepine, phenytoin, or other appropriate acute anti-seizure therapy.
Croatian: Ponavljani epileptički napadaji se trebaju liječiti primjenom benzodiazepina, fenitoina ili drugim primjerenim akutnim liječenjem epileptičkih napadaja.
English: Your doctor will be especially careful if fampridine is given at the same time as any medicine which may affect how your kidneys eliminate medicines for example carvedilol, propanolol and metformin.
Croatian: Liječnik će biti posebno oprezan ako je fampridin dan u isto vrijeme kad i neki lijek koji može utjecati na način na koji bubrezi eliminiraju lijekove, primjerice karvedilol, propranolol i metformin.
English: Distribution:
Croatian: Distribucija
English: Re-Evaluating Fampyra Treatment
Croatian: Ponovna procjena liječenja Fampyrom
English: 1 See section 4.4 2 These symptoms were observed in the context of hypersensitivity
Croatian: 2 Ovi simptomi su opaženi u okviru preosjetljivosti
English: • Difficulty breathing (shortness of breath)
Croatian: • Poteškoće s disanjem (nedostatak zraka)
English: Fampyra comes in HDPE (high-density polyethylene) bottles.
Croatian: Fampyra dolazi u bocama od HDPE (polietilen visoke gustoće).
English: • Minor shaking (tremor)
Croatian: • Nevoljno drhtanje (tremor)
English: There was evidence of direct inhibition of CYP2E1 by fampridine at 30 μM (approximately 12% inhibition) which is approximately 100 times the average plasma fampridine concentration measured for the 10 mg tablet.
Croatian: Postoje dokazi da fampridin u dozi od 30 μM izravno inhibira CYP2E1 (otprilike 12% inhibicije), što je otprilike 100 puta više od prosječne koncentracije fampridina u plazmi izmjerene za tabletu od
English: May affect more than 1 in 10 people: • Urinary tract infection
Croatian: Može zahvatiti do 1 od 100 osoba: • Epileptički napadaji (konvulzije)
English: Presumably, by enhancing action potential formation, more impulses might be conducted in the central nervous system.
Croatian: Pretpostavlja se da tako olakšan nastanak akcijskih potencijala omogućuje vođenje većeg broja živčanih impulsa u središnjem živčanom sustavu.
English: In multiple sclerosis, inflammation destroys the protective sheath around the nerves leading to muscle weakness, muscle stiffness and difficulty walking.
Croatian: U multiploj sklerozi, upalni proces uništava zaštitnu ovojnicu živaca što dovodi do slabljenja mišića, ukočenosti mišića i teškoća u hodanju.
English: In addition, single cases of fatal urinary tract obstructions were observed in rats.
Croatian: Osim toga, u štakora su opaženi pojedini slučajevi fatalne opstrukcije mokraćnih puteva.
English: Fampridine is metabolised in humans by oxidation to 3-hydroxy-4-aminopyridine and further conjugated to the 3-hydroxy-4-aminopyridine sulfate.
Croatian: U ljudskom organizmu, fampridin se metabolizira oksidacijom u 3-hidroksi-4-aminopiridin te se dalje konjugira u 3-hidroksi-4-aminopiridin sulfat.
English: Baseline 0.98 (0.078) Average change -0.09 (0.037) Difference p-value
Croatian: Početno 0,98 (0,078) Prosječna promjena -0,09 (0,037) Razlika p-vrijednost
English: − if you are taking any other medicine containing fampridine.
Croatian: − ako uzimate neki drugi lijek koji sadrži fampridin.
English: Elimination:
Croatian: Eliminacija
English: There are limited amount of data from the use of fampridine in pregnant women.
Croatian: Podaci o primjeni fampridina u trudnica su ograničeni.
English: Before starting treatment and during treatment your doctor may check that your kidneys are working properly.
Croatian: Starije osobe Prije početka liječenja ili tijekom liječenja, liječnik može provjeriti funkcioniraju li Vaši bubrezi normalno.
English: If your Fampyra is supplied in bottles, the bottle will also contain a desiccant.
Croatian: Ako Vam je Fampyra dostupna u boci, boca će također sadržavati sredstvo za sušenje.
English: BBS score
Croatian: BBS rezultat Početak
English: Fampridine is a lipid-soluble medicinal product which readily crosses the blood-brain barrier.
Croatian: Fampridin je lijek topiv u mastima koji brzo prolazi kroz krvno-moždanu barijeru.
English: The primary endpoint in studies MS-F203 and MS-F204 was the responder rate in walking speed as measured by the Timed 25-foot Walk (T25FW).
Croatian: Primarni ishod u ispitivanjima MS-F203 i MS-F204 bio je stopa bolesnika s odgovorom u poboljšanju brzine hodanja prema mjerenju vremena potrebnog za prijelaz hodne pruge od 7,6 metara (test T25FW).
English: • Numbness or tingling of skin
Croatian: • Obamrlost ili trnci na koži
English: − if you have any factors or are taking any medicine which affects your risk of fits (seizure).
Croatian: − ako imate bilo koje čimbenike ili uzimate neki lijek koji utječe na rizik od napadaja
English: Fampyra should be discontinued if patients no longer receive walking benefit.
Croatian: Liječenje Fampyrom treba prekinuti ukoliko bolesnici više ne osjećaju poboljšanje pri hodanju.
English: Fampyra treated patients also demonstrated a statistically significant improvement in the Timed Up and Go (TUG) test, a measure of static and dynamic balance and physical mobility.
Croatian: Bolesnici liječeni Fampyrom pokazali su također statistički značajno poboljšanje u testu mobilnosti „Timed Up and Go“ (TUG) kojim se mjeri statička i dinamička ravnoteža te tjelesna pokretljivost.
English: The major route of elimination for fampridine is renal excretion, with approximately 90% of the dose recovered in urine as parent medicinal product within 24 hours.
Croatian: Glavni put eliminacije fampridina je izlučivanje preko bubrega, tako da se otprilike 90% doze pojavljuje u mokraći kao izvorni lijek u roku od 24 sata.
English: Concomitant use of Fampyra with medicinal products that are inhibitors of Organic Cation Transporter 2 (OCT2) for example, cimetidine.
Croatian: Istovremena primjena Fampyre s drugim lijekovima koji su inhibitori transportera organskih kationa 2 (OCT2) primjerice, cimetidinom.
English: Fampyra is indicated for the improvement of walking in adult patients with multiple sclerosis with walking disability (EDSS 4-7).
Croatian: Fampyra je indicirana za poboljšanje hodanja u odraslih bolesnika koji boluju od multiple skleroze s nesposobnošću hodanja (EDSS 4-7).
English: The proportion of responders was independent of concomitant immunomodulatory therapy (including interferons, glatiramer acetate, fingolimod and natalizumab).
Croatian: Udio bolesnika s odgovorom nije ovisio o istodobnoj imunomodulacijskoj terapiji (uključujući interferone, glatirameracetat, fingolimod i natalizumab).
English: Patients who overdose should be provided supportive care.
Croatian: Bolesnicima koji su uzeli preveliku dozu treba pružiti suportivno liječenje.
English: A significantly greater proportion of Fampyra treated patients were responders as compared to placebo (MS-F203: 34.8% vs. 8.3%, p<0.001; MS-F204: 42.9% vs. 9.3%, p<0.001).
Croatian: Udio bolesnika s odgovorom bio je značajno veći u skupini liječenoj Fampyrom u usporedbi s placebom (MS-F203: 34,8% u usporedbi s 8,3%, p<0,001; MS-F204: 42,9% u usporedbi s 9,3%,
English: Alkermes Pharma Ireland Ltd, Monksland, Athlone, Co. Westmeath, Ireland
Croatian: Proizvođač: Alkermes Pharma Ireland Ltd, Monksland, Athlone, Co.
English: Side effects are listed below by frequency:
Croatian: Nuspojave su navedene dolje prema učestalosti:
English: If you take more Fampyra than you should Contact your doctor immediately if you take too many tablets.
Croatian: Javite se odmah svom liječniku ako uzmete previše tableta.
English: They work by stopping potassium leaving the nerve cells which have been damaged by MS.
Croatian: Oni djeluju tako da sprječavaju da kalij napušta živčane stanice koje su bile oštećene zbog multiple skleroze.
English: Fampridine is eliminated mainly via the kidneys with active renal secretion accounting for about 60% (see section 5.2).
Croatian: Fampridin se pretežno odstranjuje preko bubrega, pri čemu aktivno bubrežno izlučivanje iznosi oko 60% (vidjeti dio 5.2).
English: Faecal excretion accounts for less than 1% of the administered dose.
Croatian: Izlučivanje preko fecesa iznosi manje od 1%
English: Fampyra is primarily excreted unchanged by the kidneys.
Croatian: Fampyra se primarno izlučuje nepromijenjena putem bubrega.
English: In this secondary endpoint, a greater proportion of Fampyra treated patients achieved ≥ 15% mean improvement from baseline TUG speed over a 24 week period, compared to placebo.
Croatian: U tom sekundarnom ishodu, veći udio bolesnika liječenih Fampyrom postigao je srednju vrijednost poboljšanja ≥ 15% u odnosu na početnu brzinu testa TUG tijekom razdoblja od 24 tjedna, u usporedbi s onima koji su primali placebo.
English: This may increase your risk of side effects.
Croatian: To Vam može povećati rizik od ozbiljnih nuspojava.
English: Swallow each tablet whole, with a drink of water.
Croatian: Svaku tabletu progutajte cijelu s vodom.
English: No pharmacological activity was found for the fampridine metabolites against selected potassium channels in vitro.
Croatian: In vitro nije nađena farmakološka aktivnost metabolita fampridina u odnosu na izabrane ionske kanale za kalij.
English: Biogen Austria GmbH Tel: +43 1 484 46 13
Croatian: Österreich Biogen Austria GmbH Tel: +43 1 484 46 13
English: Fampyra is primarily excreted unchanged by the kidneys, and with creatinine clearance known to decrease with age, monitoring of renal function in older patients should be considered (see section 4.2).
Croatian: Fampyra se primarno eliminira nepromijenjena preko bubrega, a kako je poznato da se klirens kreatinina smanjuje tijekom starenja, potrebno je nadzirati bubrežne funkcije u starijih bolesnika (vidjeti dio 4.2).
English: Do not use this medicine after the expiry date which is stated on the packaging after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake „Rok valjanosti“ ili „EXP“.
English: Adverse reactions are presented below by system organ class and absolute frequency.
Croatian: Dolje su prikazane nuspojave prema klasifikaciji organskih sustava i apsolutnoj učestalosti.
English: − if you have a seizure or have ever had a seizure (also referred to as a fit or convulsion)
Croatian: − ako imate epileptički napadaj ili ste ikad imali epileptičke napadaje (koji se također nazivaju konvulzijama)
English: Talk to your doctor or pharmacist before taking Fampyra:
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku ili ljekarniku prije nego uzmete Fampyru:
English: Biogen Netherlands B.V. Prins Mauritslaan 13
Croatian: Prins Mauritslaan 13
English: Patients with renal impairment have higher plasma concentrations which are associated with increased adverse reactions, in particular neurological effects.
Croatian: Bolesnici s oštećenjem bubrega imaju povišenu koncentraciju u krvnoj plazmi, što je povezano s povećanom učestalošću nuspojava, naročito onih neurološke naravi.
English: MSWS-12 score
Croatian: Rezultat MSWS-12 Početak
English: Central nervous system side effects at high doses of 4-aminopyridine include confusion, seizures, status epilepticus, involuntary and choreoathetoid movements.
Croatian: Nuspojave središnjeg živčanog sustava pri visokim dozama 4-aminopiridina uključuju konfuziju, napadaje, status epilepticus, nevoljne i koreoatetotične kretnje.
English: The highest incidence of adverse reactions identified from placebocontrolled trials in multiple sclerosis patients with Fampyra given at the recommended dose, are reported as urinary tract infection (in approximately 12% of patients).
Croatian: Nuspojava s najvećom incidencijom utvrđenom tijekom placebom kontroliranih istraživanja u bolesnika s multiplom sklerozom i s Fampyrom u preporučenoj dozi jest infekcija mokraćnog sustava (u otprilike 12% bolesnika).
English: In post-marketing experience, there have been reports of hypersensitivity reactions (including anaphylaxis) which have occurred with one or more of the following: dyspnoea, chest discomfort, hypotension, angioedema, rash and urticaria.
Croatian: U postmarketinškom razdoblju bilo je prijava reakcija preosjetljivosti (uključujući i anafilaksiju) koje su se pojavile s jednim ili više događaja kako slijedi: dispneja, nelagoda u prsnom košu, hipotenzija, angioedem, osip i urtikarija.
English: Exacerbation of trigeminal neuralgia
Croatian: Egzacerbacija trigeminalne neuralgije
English: Patients who responded to Fampyra increased their walking speed on average by 26.3% vs 5.3% on placebo (p<0.001) (MS-F203) and 25.3% vs 7.8% (p< 0.001) (MS-F204).
Croatian: Bolesnici kod kojih je Fampyra imala pozitivan učinak su povećali brzinu hodanja u prosjeku za 26,3%, u usporedbi s 5,3% u skupini koja je uzimala placebo (p<0,001) (MS-F203) i 25,3% u usporedbi s 7,8% (p< 0,001) (MS-F204).
English: Walking speed Feet/sec
Croatian: Brzina hoda stopa (ft)/sek
English: Table 2: Study 218MS305
Croatian: Tablica 2: Ispitivanje 218MS305
English: Thus, the concomitant use of fampridine with medicinal products that are inhibitors of OCT2 for example, cimetidine are contraindicated (see section 4.3) and concomitant use of fampridine with medicinal products that are substrates of OCT2 for example, carvedilol, propanolol and metformin is cautioned (see section 4.4.)
Croatian: Prema tome, istovremena primjena fampridina s lijekovima koji su inhibitori OCT2, kao što je cimetidin, jest kontraindicirana (vidjeti dio 4.3), a pri istovremenoj primjeni fampridina s lijekovima koji su supstrati za OCT2, na primjer karvedilol, propranolol i metformin, potreban je oprez (vidjeti dio 4.4.)
English: Alkermes Pharma Ireland Ltd Monksland
Croatian: Alkermes Pharma Ireland Ltd
English: In this study there was a statistically significant treatment difference, with a greater proportion of Fampyra treated patients demonstrating an improvement in walking ability, compared to placebo-controlled patients (relative risk of 1.38 (95% CI: [1.06, 1.70]).
Croatian: U ovom ispitivanju pokazala se statistički značajna razlika između liječenja, pri čemu je udio bolesnika koji su pokazali poboljšanje u mogućnosti hodanja bio veći u skupini liječenoj Fampyrom nego u skupini kontrolnih bolesnika liječenih placebom (relativni rizik od 1,38 (95% CI: [1,06; 1,70]).
English: Hypersensitivity Reactions
Croatian: Reakcije preosjetljivosti
English: Biogen Portugal Sociedade Farmacêutica Unipessoal, Lda
Croatian: Portugal Biogen Portugal Sociedade Farmacêutica
English: Interferon: fampridine has been administered concomitantly with interferon-beta and no pharmacokinetic medicinal product interactions were observed.
Croatian: Interferon: tijekom istodobne primjene fampridina i beta-interferona nisu opažene farmakokinetičke interakcije lijekova.
English: Each bottle contains 14 tablets and a silica gel desiccant.
Croatian: Jedna boca sadrži 14 tableta i silikagel kao sredstvo za sušenje.
English: Concurrent treatment with other medicinal products containing fampridine (4-aminopyridine) is contraindicated (see section 4.3).
Croatian: Istodobno liječenje drugim lijekovima koji sadrže fampridin (4-aminopiridin) je kontraindicirano (vidjeti dio 4.3).
English: An off-white, film coated, oval biconvex 13 x 8 mm tablet with flat edge debossed with A10 on one side.
Croatian: Gotovo bijela, filmom obložena, ovalna bikonveksna 13 x 8 mm tableta s ravnim rubom i utisnutom oznakom A10 na jednoj strani.
English: Biogen Finland Oy Puh/Tel: +358 207 401 200
Croatian: Suomi/Finland Biogen Finland Oy Puh/Tel: +358 207 401 200