FrancophonIA/ELRC3.0 huggingface dataset:
English: Co-administration of Vitekta with moderate CYP3A inducers (including, but not limited to, efavirenz and bosentan) is not
Croatian: Ne preporučuje se istovremena primjena lijeka Vitekta i umjerenih induktora CYP3A (uključujući, bez ograničenja, efavirenz i bosentan) (vidjeti dio 4.5).
English: There are no data available to make dosing recommendations for co-administration with other doses of fosamprenavir (see section 4.2).
Croatian: Ne postoje dostupni podaci o preporukama doziranja za istovremenu primjenu s drugim dozama fosamprenavira (vidjeti dio 4.2).
English: Each film-coated tablet contains 150 mg elvitegravir.
Croatian: Jedna filmom obložena tableta sadrži 150 mg elvitegravira.
English: No dose adjustment is required when Vitekta is co-administered with methadone.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje s metadonom.
English: No dose adjustment is required when Vitekta is co-administered with buprenorphine/naloxone.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje s buprenorfinom/naloksonom.
English: Elvitegravir-resistant viruses show cross-resistance to the integrase strand transfer inhibitor raltegravir
Croatian: Virusi rezistentni na elvitegravir u većini slučaja pokazuju križnu rezistenciju na raltegravir, inhibitor prijenosa lanca integraze (vidjeti dio 5.1).
English: • darunavir and ritonavir
Croatian: • darunavir i ritonavir
English: Rosuvastatin (10 mg single dose) Elvitegravir (150 mg once daily) Cobicistat (150 mg once daily)
Croatian: Rosuvastatin (jednokratna doza od Elvitegravir (150 mg jedanput na Kobicistat (150 mg jedanput na
English: The active substance elvitegravir is persistent in the environment.
Croatian: Djelatna tvar elvitegravir nije razgradiva u okolišu.
English: Slovenská republika Gilead Sciences International Ltd Tel: + 44 (0) 20 7136 8820
Croatian: Slovenská republika Gilead Sciences International Ltd Tel: + 44 (0) 20 7136 8820 Suomi/Finland
English: Elvitegravir (85 mg once daily) Atazanavir (300 mg once daily) Ritonavir (100 mg once daily)
Croatian: Atazanavir (300 mg jedanput na Elvitegravir (85 mg jedanput na Ritonavir (100 mg jedanput na
English: Signs of osteonecrosis are: - joint stiffness - joint aches and pains (especially of the hip, knee and shoulder) - difficulty with movement.
Croatian: Znakovi tupi bolovi i probadanje u zglobovima (osobito u kuku, koljenu i ramenu), Ako primijetite bilo koji od ovih simptoma, obavijestite svog liječnika.
English: A dose of 150 mg is recommended: If you are taking Vitekta with:
Croatian: Ako lijek Vitekta uzimate s:
English: Lopinavir/Ritonavir has been shown to significantly increase the plasma concentrations of
Croatian: Pokazalo se da atazanavir/ritonavir značajno povećavaju koncentracije
English: Effects on drug levels Mean percent change in AUC,
Croatian: Učinci na razine lijekova Srednja vrijednost postotka promjene AUC, Cmax, Cmin
English: Due to inhibition of CYP3A by ritonavir, 25-O-desacetyl-rifabutin exposure is increased.
Croatian: Izloženost 25-O-desacetilrifabutinu je povećana zbog inhibicije CYP3A ritonavirom.
English: No dose adjustment is required when Vitekta is co-administered with maraviroc.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje s maravirokom.
English: No dose adjustment is required when Vitekta is co-administered with rosuvastatin.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje s rosuvastatinom.
English: §Due to inhibition of CYP3A by ritonavir, 25-O-desacetyl-rifabutin exposure is increased.
Croatian: §Izloženost 25-O-desacetilrifabutinu je povećana zbog inhibicije CYP3A ritonavirom.
English: Suomi/Finland Gilead Sciences Sweden AB Puh/Tel: + 46 (0) 8 5057 1849
Croatian: Gilead Sciences Sweden AB Puh/Tel: + 46 (0) 8 5057 1849 Sverige
English: No dose adjustment is required when Vitekta is co-administered with omeprazole.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje s omeprazolom.
English: Tenofovir disoproxil fumarate (300 mg once daily) Emtricitabine (200 mg once daily) Elvitegravir (50 mg once daily)
Croatian: Tenofovirdizoproksilfumarat (300 mg jedanput na dan) Emtricitabin (200 mg jedanput na dan)
English: No dose adjustment is required when Vitekta is co-administered with zidovudine.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje sa zidovudinom.
English: Famotidine (40 mg once daily) Elvitegravir (150 mg once daily) Cobicistat (150 mg once daily)
Croatian: Famotidin (40 mg jedanput na dan) Elvitegravir (150 mg jedanput na
English: §Due to inhibition of CYP3A by ritonavir, ketoconazole exposure is increased.
Croatian: §Izloženost ketokonazolu je povećana zbog inhibicije CYP3A ritonavirom.
English: No dose adjustment is required when Vitekta is co-administered with abacavir.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje s abakavirom.
English: Fosamprenavir (700 mg twice daily)
Croatian: Ritonavir (200 mg dvaput na dan)
English: Elvitegravir (50 mg once daily) Ritonavir (100 mg once daily)
Croatian: Elvitegravir (200 mg jedanput na Ritonavir (100 mg jedanput na
English: CCR5 antagonists Maraviroc (150 mg twice daily) Elvitegravir (150 mg once daily) Ritonavir (100 mg once daily)
Croatian: Maravirok (150 mg dvaput na dan) Elvitegravir (150 mg jedanput na dan)
English: A dose of 85 mg is recommended: If you are taking Vitekta with:
Croatian: Preporučena doza je 85 mg:
English: Skin and subcutaneous tissue disorders: General disorders and administration site conditions:
Croatian: Opći poremećaji i reakcije na mjestu primjene:
English: §Due to inhibition of CYP3A by ritonavir, maraviroc exposure is significantly increased.
Croatian: Izloženost maraviroku značajno je povećana zbog inhibicije CYP3A ritonavirom.
English:  If you get any side effects, talk to your doctor or pharmacist.
Croatian: Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
English: Abacavir (600 mg once daily) Elvitegravir (200 mg once daily) Ritonavir (100 mg once daily)
Croatian: Fosamprenavir (700 mg dvaput na Elvitegravir (125 mg jedanput na Ritonavir (100 mg dvaput na dan)
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product
Croatian: UVJETI ILI OGRANIČENJA VEZANI UZ OPSKRBU I PRIMJENU C. OSTALI UVJETI I ZAHTJEVI ODOBRENJA ZA STAVLJANJE
English: Nervous system disorders:
Croatian: Oštećenje funkcije bubrega
English: Elvitegravir (150 mg once daily) Cobicistat (150 mg once daily)
Croatian: Elvitegravir (150 mg jedanput na dan)
English: The in vitro antiviral activity of elvitegravir when combined with antiretroviral drugs from the nucleos(t)ide reverse transcriptase inhibitor (NRTI), non-nucleoside reverse transcriptase inhibitor (NNRTI), protease inhibitor (PI),
Croatian: Nenukleozidni inhibitori reverzne transkriptaze (NNRTI)
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Gilead Sciences Intl Ltd
Croatian: Nositelj odobrenja za stavljanje lijeka u promet Gilead Sciences International Limited
English: If you notice signs of inflammation or infection, tell your doctor at once.
Croatian: Odmah obavijestite svog liječnika ako primijetite znakove upale ili infekcije.
English: No dose adjustment is required when Vitekta is co-administered with stavudine.
Croatian: Prilagodba doze nije potrebna kada se Vitekta istovremeno primjenjuje sa stavudinom.
English: What Invokana is and what it is used for
Croatian: Što je Invokana i za što se koristi
English: See section 3, “Taking this medicine”.
Croatian: Pogledajte dio 3, „Uzimanje ovog lijeka”.
English: • fast and deep breathing
Croatian: • ubrzano i duboko disanje
English: These differences are not considered to be clinically meaningful.
Croatian: Ove razlike se ne smatraju klinički značajnima.
English: If a dose is missed, it should be taken as soon as the patient remembers; however, a double dose should not be taken on the same day.
Croatian: U slučaju da propusti dozu, bolesnik ju treba uzeti čim se sjeti; međutim, ne smije se uzeti dvostruka doza u istom danu.
English: ATC code: A10BK02.
Croatian: ATK oznaka: A10BK02.
English: More information is given below in “Other medicines and Invokana”.
Croatian: Više informacija možete pronaći niže, u dijelu „Drugi lijekovi i Invokana“.
English: Possible signs of losing too much fluid from your body are listed in section 4.
Croatian: Mogući znakovi prevelikog gubitka tjelesne tekućine navedeni su u dijelu 4.
English: This reduces the amount of sugar in your blood and can help prevent heart disease.
Croatian: To smanjuje količinu šećera u Vašoj krvi i može pomoći spriječiti razvoj srčane bolesti.
English: • if you have ever had serious heart disease or if you have had a stroke.
Croatian: • ako ste ikada imali ozbiljnu bolest srca ili ako ste ikada imali moždani udar.
English: • about what you can do to prevent dehydration (see section 4 for signs of dehydration).
Croatian: • vezano uz to što možete poduzeti radi sprječavanja dehidracije (pogledajte dio 4 za znakove dehidracije)
English: Date of first authorisation: 15 November 2013 Date of latest renewal: 26 July 2018
Croatian: Datum posljednje obnove odobrenja: 26. srpnja 2018.
English: The doctor may decide to temporarily or permanently stop the treatment with Invokana.
Croatian: Vaš liječnik može odlučiti privremeno ili trajno prekinuti Vaše liječenje lijekom Invokana.
English: • if you have type 1 diabetes because Invokana should not be used to treat this condition.
Croatian: • ako imate šećernu bolest tipa 1 jer se Invokana ne smije uzimati za liječenje ovog stanja.
English: If you take more of this medicine than you should, talk to a doctor or go to the nearest hospital immediately.
Croatian: Ako uzmete više ovog lijeka nego što biste trebali, obratite se liječniku ili otiđite odmah u najbližu bolnicu.
English: • increased levels of “ketone bodies” in your urine or blood
Croatian: • povišene razine „ketonskih tijela“ u mokraći ili krvi
English: The racial distribution was 72% White, 16% Asian, 5% Black, and 8% other groups.
Croatian: Raspodjela po rasama bila je 72% bijelaca, 16% azijata, 5% crnaca i 8% ostalih skupina.
English: Stop taking Invokana and talk to a doctor or go to the nearest hospital immediately if you have any of the following serious side effects:
Croatian: Prestanite uzimati lijek Invokana i obratite se liječniku ili odmah otiđite u najbližu bolnicu ako imate bilo koju od sljedećih ozbiljnih nuspojava:
English: Each MACE component positively contributed to the overall composite, as shown in Figure 2.
Croatian: Svaki je pojedinačna sastavnica MACE događaja pozitivno pridonijela ukupnoj kompozitnoj mjeri ishoda, što je prikazano na Slici 2.
English: Balanitis or balanoposthitis b,l
Croatian: Balanitis ili balanopostitis b,l
English: Figure 1: Time to First Occurrence of MACE
Croatian: Vrijeme do prvog nastupa MACE događaja
English: Frequency categories are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Croatian: Katregorije učestalosti su definirane prema sljedećem sporazumu: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: • unusual sleepiness or tiredness
Croatian: • neuobičajena pospanost ili umor
English: Kidney function Your kidneys will be tested by a blood test before you start taking and while you are on this medicine.
Croatian: Funkcija Vaših bubrega bit će provjeravana krvnim pretragama prije početka uzimanja i dok uzimate ovaj lijek.
English: Diabetic ketoacidosis (rare, may affect up to 1 in 1,000 people) These are the signs of diabetic ketoacidosis (see also section 2):
Croatian: Dijabetička ketoacidoza (rijetko, može se javiti u do 1 na 1000 osoba) Ovo su znakovi dijabetičke ketoacidoze (također pogledajte dio 2):
English: • kidney failure (mainly as a consequence of loss of too much fluid from your body).
Croatian: • zatajenje bubrega (većinom kao posljedica prevelikog gubitka tekućine iz Vašeg tijela)
English: In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute clinical measures if required.
Croatian: U slučaju predoziranja, opravdano je primijeniti uobičajene potporne mjere, npr. ukloniti neapsorbirani lijek iz gastrointestinalnog sustava, vršiti klinički nadzor, te po potrebi uvesti kliničke mjere.
English: canagliflozin N = 5790
Croatian: Kanagliflozin N = 5790
English: • The starting dose of Invokana is one 100 mg tablet each day.
Croatian: • Početna doza lijeka Invokana je jedna tableta od 100 mg svaki dan.
English: Diabetic ketoacidosis b,h
Croatian: Dijabetička ketoacidoza b,h
English: Invokana is available in PVC/aluminium perforated unit dose blisters.
Croatian: Invokana je dostupna u PVC/aluminij perforiranim blisterima s jediničnim dozama.
English: Before initiating Invokana, consider factors in the patient history that may increase the risk for amputation.
Croatian: Prije uvođenja lijeka Invokana potrebno je razmotriti faktore iz bolesnikove anamneze koji bi mogli povećati rizik od amputacije.
English: Moderate increases (generally < 400 mL to 500 mL) in daily urine volume were seen that attenuated over several days of dosing.
Croatian: Uvidjelo se da su umjerena povišenja (uglavnom < 400 ml do 500 ml) u dnevnom volumenu mokraće umanjena kroz nekoliko dana doziranja.
English: Two hundred eleven (211) patients from the clinical study in older patients participated in a body composition substudy using DXA body composition analysis.
Croatian: Dvjesto i jedanaest (211) bolesnika iz kliničkih ispitivanja sa starijim bolesnicima sudjelovali su u podispitivanju sastava tijela korištenjem DXA analize sastava tijela.
English: Figure 2: Treatment Effect for the Primary Composite Endpoint and its Components
Croatian: Slika 2: Utjecaj liječenja za primarnu kompozitnu mjeru ishoda i njezine pojedinačne sastavnice
English: Medicinal product/Laboratory test interference
Croatian: Interferencija s lijekovima/laboratorijskim pretragama
English: Treatment with canagliflozin may be restarted when the ketone values are normal and the patient's condition has stabilised.
Croatian: Liječenje kanagliflozinom može se ponovno započeti nakon što vrijednosti razine ketona ponovo postanu normalne i bolesnikovo stanje je stabilizirano.
English: • if you have severe kidney problems or are on dialysis.
Croatian: • ako imate teške probleme s bubrezima ili ste na dijalizi.
English: • if you have severe liver problems.
Croatian: • ako imate teške probleme s jetrom.
English: Related to bone fracture; see description of AR below.
Croatian: Povezano s frakturom kostiju; vidjeti opis nuspojave u nastavku..
English: - as monotherapy when metformin is considered inappropriate due to intolerance or contraindications - in addition to other medicinal products for the treatment of diabetes.
Croatian: - kao monoterapija kada se primjena metformina ne smatra prikladnom zbog nepodnošenja ili kontraindikacija - kao dodatak drugim lijekovima za liječenje dijabetesa
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja galaktoze, potpunim nedostatkom laktaze ili malapsorpcijom glukoze i galaktoze ne bi smjeli uzimati ovaj lijek.
English: For study results with respect to combination of therapies, effects on glycaemic control and cardiovascular events, and the populations studied, see sections 4.4, 4.5, and 5.1.
Croatian: Za rezultate ispitivanja koji se odnose na kombinirane terapije, učinke na regulaciju glikemije i kardiovaskularne događaje, te ispitivane populacije vidjeti dijelove 4.4, 4.5 i 5.1.
English: Due to its mechanism of action, canagliflozin, by increasing urinary glucose excretion (UGE) induces an osmotic diuresis, which may reduce intravascular volume and decrease blood pressure (see section 5.1).
Croatian: Zbog svog mehanizma djelovanja, kanagliflozin, povećavajući ekskreciju glukoze urinom (UGE) inducira osmotsku diurezu, što može reducirati intravaskularni volumen i smanjiti krvni tlak (vidjeti dio 5.1).
English: • if you experience rapid weight loss, feeling sick or being sick, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat, talk to a doctor or go to the nearest hospital immediately.
Croatian: • ako iskusite nagli gubitak tjelesne težine, osjećaj mučnine ili povraćanje, bol u trbuhu, prekomjernu žeđ, ubrzano i duboko disanje, smetenost, neuobičajenu pospanost ili umor, zadah slatkog mirisa, slatki ili metalni okus u ustima ili drugačiji miris mokraće ili znoja, odmah razgovarajte sa svojim liječnikom ili odmah otiđite u najbližu bolnicu.
English: A total of 10,501 patients with type 2 diabetes participated in ten double-blind, controlled clinical efficacy and safety studies conducted to evaluate the effects of Invokana on glycaemic control.
Croatian: Ukupno 10 501 bolesnik s dijabetesom tipa 2 sudjelovao je u deset dvostruko slijepih, kontroliranih ispitivanja kliničke djelotvornosti i sigurnosti koje su provedene radi procjene djelotvornosti lijeka Invokana na regulaciju glikemije.
English: Invokana contains the active substance canagliflozin which belongs to a group of medicines called “blood-glucose lowering drugs.”
Croatian: Invokana sadrži djelatnu tvar kanagliflozin koja pripada skupini lijekova koji se nazivaju „lijekovi za snižavanje šećera u krvi.“
English: • blood tests may show changes related to kidney function (increased creatinine or urea) or increased potassium
Croatian: • krvne pretrage mogu pokazati promjene povezane s bubrežnom funkcijom (povišen kreatinin ili urea) ili povišenim kalijem
English: Invokana is used in adults to treat type 2 diabetes.
Croatian: Lijek Invokana uzimaju odrasli za liječenje šećerne bolesti tipa 2.
English: In a number of cases, the presentation of the condition was atypical with only moderately increased blood glucose values, below 14 mmol/l (250 mg/dL).
Croatian: U brojnim slučajevima stanje se očitovalo atipično, uz samo umjereno povišene vrijednosti glukoze u krvi, ispod 14 mmol/l (250 mg/dl).
English: To assess risk factors for these adverse reactions, a larger pooled analysis (N = 12,441) of patients from 13 controlled phase 3 and phase 4 studies including both doses of canagliflozin was conducted.
Croatian: U svrhu procjene faktora rizika za te nuspojave, provedena je veća analiza objedinjenih podataka (N = 12 441) bolesnika iz 13 kontroliranih ispitivanja faze 3 i faze 4, uključujući obje doze kanagliflozina.
English: These symptoms could be a sign of “diabetic ketoacidosis” - a rare but serious, sometimes life-threatening problem you can get with diabetes because of increased levels of “ketone bodies” in your urine or blood, seen in tests.
Croatian: Ovi simptomi mogu biti znak „dijabetičke ketoacidoze“ - rijetkog ali ozbiljnog, ponekad i po život opasnog problema koji se može javiti uz šećernu bolest zbog povišenih razina „ketonskih tijela“ u mokraći ili krvi, što je vidljivo u nalazima pretraga.
English: In a pooled analysis of 13 placebo-controlled and active-controlled studies, the safety profile of canagliflozin in elderly patients was generally consistent with younger patients.
Croatian: Analizom objedinjenih podataka iz 13 placebom kontroliranih i aktivno kontroliranih ispitivanja, sigurnosni profil kanagliflozina u starijih bolesnika općenito je u skladu s onim u mlađih bolesnika.
English: • a sweet smell to your breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat.
Croatian: • zadah slatkog mirisa, slatki ili metalni okus u ustima ili drugačiji miris mokraće ili znoja.
English: If Fournier's gangrene is suspected, Invokana should be discontinued and prompt treatment (including antibiotics and surgical debridement) should be instituted.
Croatian: Ako se sumnja na Fournierovu gangrenu, potrebno je prekinuti uzimanje lijeka X te hitno započeti s liječenjem (uključujući antibiotike i kirurški debridman).
English: Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Invokana, and during treatment:
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete lijek Invokana, te tijekom liječenja:
English: See the package leaflet for further information.
Croatian: Vidjeti uputu o lijeku za dodatne informacije.
English: In addition, in such patients more events of elevated potassium and greater increases in serum creatinine and blood urea nitrogen (BUN) were reported (see section 4.8).
Croatian: Dodatno, u takvih bolesnika prijavljeno je više događaja povišenog kalija i veće povišenje serumskog kreatinina i ureje u krvi (BUN) (vidjeti dio 4.8).
English: • excessive thirst
Croatian: • prekomjerna žeđ
English: “CFZ” on one side and “100” on the other side.
Croatian: 11 mm, s „CFZ“ na jednoj strani i „100“ na drugoj strani.
English: • lower limb amputations (mainly of the toe) especially if you are at high risk of heart disease.
Croatian: • amputacije donjih udova (većinom nožnog prsta) naročito ako imate visoki rizik za bolesti srca
English: Pharmacotherapeutic group: Drugs used in diabetes, blood glucose lowering drugs, excluding insulins.
Croatian: Farmakoterapijska skupina: Lijekovi za liječenje dijabetesa, lijekovi za sniženje glukoze u krvi, isključujući inzuline.
English: If you stop taking Invokana
Croatian: Ako prestanete uzimati lijek Invokana
English: Taking this medicine • Swallow the tablet whole with water.
Croatian: • Progutajte tabletu cijelu s vodom.
English: The mean steady-state volume of distribution of canagliflozin following a single intravenous infusion in healthy subjects was 83.5 litres, suggesting extensive tissue distribution.
Croatian: Srednja vrijednost volumena distribucije kanagliflozina u stanju dinamičke ravnoteže nakon jedne intravenske infuzije u zdravih ispitanika bila je 83,5 litara, što ukazuje na opsežnu distribuciju u tkiva.
English: The marketing authorization holder (MAH) shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the marketing authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), a koji se nalazi u Modulu 1.8.2
English: N = 4344
Croatian: Placebo N = 4344
English: A subset of patients (N = 208) from the active-controlled dual therapy study with metformin who underwent dual energy X-ray densitometry (DXA) and abdominal computed tomography (CT) scans for evaluation of body composition demonstrated that approximately two-thirds of the weight loss with canagliflozin was due to loss of fat mass with similar amounts of visceral and abdominal subcutaneous fat being lost.
Croatian: Podskup bolesnika (N = 208) iz dvojne terapije ispitivanja s aktivnim usporednim lijekom s metforminom u kojem su bili podvrgnuti denzitometriji X-zrakama dualne energije (DXA) i kompjuteriziranoj tomografiji (CT) abdomena za procjenu sastava tijela, pokazao je da se oko dvije trećine gubitka težine s kanagliflozinom dogodio zbog gubitka mase masnoće uz sličan gubitak visceralne i abdominalne supkutane masnoće.