FrancophonIA/ELRC3.0 huggingface dataset:
English: Treatment with Javlor should be started under the supervision of a doctor qualified to use anticancer medicines and is only given in specialised hospital units.
Estonian: Ravi Javloriga tohib alustada üksnes vähiravimite kasutamise pädevusega arsti järelevalve all ja sellisele ravile spetsialiseerunud osakonnas.
English: For the full list of all side effects reported with Javlor, see the package leaflet.
Estonian: Javlori kohta teatatud kõrvalnähtude täielik loetelu on pakendi infolehel.
English: Among all patients in the study, there was no clear evidence of a difference in survival between patients who received Javlor and those who did not.
Estonian: Uuringus osalenud patsientide elulemuses ei ilmnenud selgeid erinevusi sõltuvalt sellest, kas patsient sai või ei saanud Javlorit.
English: What benefit has Javlor shown during the studies?
Estonian: Milles seisneb uuringute põhjal Javlori kasulikkus?
English: Javlor is used for the treatment of adults with advanced or metastatic ‘transitional cell carcinoma of the urothelial tract' (a cancer that affects the lining of the bladder and the rest of the urinary tract).
Estonian: Javlorit kasutatakse täiskasvanutel uroteeli (kusepõie ja kuseteede limaskesta) kaugelearenenud või metastaatilise transitoorrakulise kartsinoomi (teatud vähiliik) raviks.
English: The medicine can only be obtained with a prescription.
Estonian: Javlor on retseptiravim.
English: How is Javlor used?
Estonian: Kuidas Javlorit kasutatakse?
English: What is Javlor used for?
Estonian: Milleks Javlorit kasutatakse?
English: This is because low levels of haemoglobin (a protein found in red blood cells that carries oxygen around the body) and blood cells (white blood cells and platelets) are frequent side effect of the medicine.
Estonian: Enne Javlori manustamist peab tegema patsiendile vereanalüüsi, et kontrollida vererakkude ja hemoglobiini sisaldust, sest ravimi sagedane kõrvalnäht on hemoglobiini (vere punaliblede valk, mis kannab hapnikku organismis laiali) ja vererakkude (leukotsüütide (valgeliblede) ja trombotsüütide (vereliistakute)) vähene sisaldus.
English: Measures to prevent constipation, such as laxatives, are recommended after Javlor is given in the first week.
Estonian: Esimesel ravinädalal on pärast Javlori manustamist soovitav võtta lahtisteid kõhukinnisuse ennetamiseks.
English: How has Javlor been studied?
Estonian: Kuidas Javlorit uuriti?
English: 1 pre-filled pen
Estonian: 1 pensüstel
English: The patients were treated for up to 23 months.
Estonian: Patsiente raviti kuni 23 kuud.
English: Forsteo teriparatide
Estonian: Forsteo teriparatiid
English: What measures are being taken to ensure the safe and effective use of Forsteo?
Estonian: Mis meetmed võetakse, et tagada Forsteo ohutu ja efektiivne kasutamine?
English: Patients may inject themselves once they have been trained.
Estonian: Patsiendid võivad end ise süstida, kui nad on saanud asjakohase väljaõppe.
English: The full EPAR for Forsteo can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Estonian: Euroopa avaliku hindamisaruande täistekst Forsteo kohta on ameti veebilehel: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: Forsteo has been studied in three main studies.
Estonian: Forsteot uuriti kolmes põhiuuringus.
English: The main measure of effectiveness was the number of new vertebral fractures at the end of the study, although the study also looked at non-vertebral fractures.
Estonian: Efektiivsuse põhinäitaja oli uute lülisambamurdude arv uuringu lõpus, kuigi vaadeldi ka muid luumurde.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Forsteo on 10 June 2003.
Estonian: Euroopa Komisjon andis Forsteo müügiloa, mis kehtib kogu Euroopa Liidu territooriumil, 10. juunil
English: Other information about Forsteo
Estonian: Muu teave Forsteo kohta
English: Forsteo must not be used in children or in young adults whose bones are not yet fully mature, or during pregnancy or breastfeeding.
Estonian: Forsteot ei tohi kasutada lapsed ja noorukid, kelle luud alles kasvavad, ega raseduse või imetamise ajal.
English: Gradually, the bones become thin and fragile, and more likely to break.
Estonian: Luud muutuvad järk-järgult urbsemaks ja hapramaks ning luumurru tõenäosus suureneb.
English: It is available as a solution for injection in prefilled pens (one 2.4 ml prefilled pen contains 600 micrograms of teriparatide).
Estonian: Seda turustatakse süstelahusena eeltäidetud pensüstaldes (üks 2,4 ml eeltäidetud pensüstal sisaldab 600 µg teriparatiidi).
English: The CHMP concluded that Forsteo's benefits are greater than its risks and recommended that it be given marketing authorisation.
Estonian: Inimravimite komitee järeldas, et Forsteo kasulikkus on suurem kui sellega kaasnevad riskid, ja soovitas anda ravimi müügiloa.
English: • men who are at an increased risk of fractures;
Estonian: • suurenenud luumurruohuga mehed;
English: The most common side effect with Forsteo (seen in more than 1 patient in 10) is pain in the arms or legs.
Estonian: Forsteo kõige sagedam kõrvalnäht (esinenud enam kui 1 patsiendil 10st) oli valu kätes või jalgades.
English: What is Forsteo?
Estonian: Mis on Forsteo?
English: Forsteo must not be used in patients who have other bone diseases such as Paget's disease, bone cancer or bone metastases (cancer that has spread to the bone), patients who have had radiation therapy of the skeleton, or patients who have hypercalcaemia (high blood calcium levels), unexplained high levels of alkaline phosphatase (an enzyme) or severe kidney disease.
Estonian: Seda ei tohi kasutada patsiendid, kellel on mõni muu luuhaigus, nt Pageti tõbi, luuvähk või luumetastaasid (luudesse levinud vähisiirded), kes on saanud luustiku kiiritusravi, või patsiendid, kellel on hüperkaltseemia (kaltsiumi liigne sisaldus veres), alkaalfosfataasi (teatud ensüümi) seletamatult suur sisaldus või raske neeruhaigus.
English: The study included 429 women and men who had osteoporosis and had been taking glucocorticoids for at least three months.
Estonian: Uuringus osales 429 osteoporoosiga naist ja meest, kes olid saanud glükokortikoide vähemalt kolm kuud.
English: This is a summary of the European public assessment report (EPAR) for Forsteo.
Estonian: See on ravimi Forsteo Euroopa avaliku hindamisaruande kokkuvõte.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Forsteo.
Estonian: Selles selgitatakse, kuidas inimravimite komitee hindas ravimit ja otsustas toetada müügiloa andmist; samuti esitatakse komitee soovitused, kuidas ravimit kasutada.
English: For more information about treatment with Forsteo, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Estonian: Kui vajate Forsteoga toimuva ravi kohta lisateavet, lugege palun pakendi infolehte (mis on samuti Euroopa avaliku hindamisaruande osa) või pöörduge oma arsti või apteekri poole.
English: The studies also showed that the benefits of Forsteo treatment continued to increase for up to two years, with further increases in bone density.
Estonian: Uuringud näitasid ka, et Forsteo ravi kasulikkus kasvas kuni kaks aastat, sest luutihedus suurenes veelgi.
English: Why has Forsteo been approved?
Estonian: Miks Forsteo heaks kiideti?
English: Forsteo is a medicine that contains the active substance teriparatide.
Estonian: Forsteo on ravim, mis sisaldab toimeainena teriparatiidi.
English: Only one two-year course of Forsteo should be given to a patient in their lifetime.
Estonian: Patsiendile tohib teha Forsteo kaheaastast ravikuuri vaid üks kord elus.
English: Osteoporosis happens when not enough new bone grows to replace the bone that is naturally broken down.
Estonian: Osteoporoos tekib, kui looduslikult laguneva luukoe asemele ei teki piisavalt uut kude.
English: • men and women who are at an increased risk of fractures due to long-term treatment with glucocorticoids (a type of steroid).
Estonian: • mehed ja naised, kellel on suurem luumurruoht pikaajalise glükokortikoidravi tõttu
English: What is the risk associated with Forsteo?
Estonian: Mis riskid Forsteoga kaasnevad?
English: In these patients, Forsteo has been shown to significantly reduce vertebral (spine) and non-vertebral fractures (broken bones), but not those of the hip;
Estonian: Neil patsientidel on tõendatud, et Forsteo vähendab märkimisväärselt lülisamba- ja muid luumurde, kuid mitte puusamurde;
English: The first study involved 1,637 women with osteoporosis who had been through the menopause (average age: 69.5 years), in which Forsteo was compared with placebo (a dummy treatment) for an average of 19 months.
Estonian: Esimeses uuringus osales 1637 osteoporoosiga menopausijärgses eas naist (keskmine vanus 69,5 aastat), kellel võrreldi keskmiselt 19 kuu vältel Forsteot platseeboga (näiva ravimiga).
English: Osteoporosis can also occur in both sexes as a side effect of glucocorticoid treatment.
Estonian: Osteoporoos võib esineda glükokortikoidravi kõrvalnähuna mõlemal sugupoolel.
English: The active substance in Forsteo, teriparatide, is identical to part of the human parathyroid hormone.
Estonian: Forsteo toimeaine teriparatiid on inimese kõrvalkilpnäärme hormooni osaga identne.
English: In the study in men, Forsteo increased bone density in the spine by about 6% after an average of almost 12 months.
Estonian: Meespatsientide uuringus suurendas Forsteo lülisamba luutihedust keskmiselt 12 kuud kestnud ravi järel ligikaudu 6%.
English: In the study of patients taking glucocorticoids, Forsteo was more effective than alendronate: after 18 months, patients receiving Forsteo had a 7% increase in bone density in the spine, compared with 3% in those receiving alendronate.
Estonian: Glükokortikoide manustavatel patsientidel oli Forsteo efektiivsem kui alendronaat: 18 kuu pärast suurenes Forsteot saanud patsientidel lülisamba luutihedus 7%, alendronaati saanud patsientidel aga
English: Forsteo is used for the treatment of osteoporosis (a disease that makes bones fragile) in the following groups:
Estonian: Forsteot kasutatakse osteoporoosi (luu-urbnemuse) raviks järgmistes patsiendirühmades:
English: Patients should receive calcium and vitamin D supplements if they do not get enough from their diet. Forsteo can be used for up to two years.
Estonian: Kui patsient ei saa toidust piisavalt kaltsiumi ja D-vitamiini, tuleb neid täiendavalt võtta.
English: The recommended dose is 20 micrograms of Forsteo given once a day as an injection under the skin of the thigh or abdomen (tummy).
Estonian: Soovituslik annus on 20 µg Forsteot manustatuna üks kord ööpäevas nahaaluse süstina reie- või kõhupiirkonda.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Forsteo have been included in the summary of product characteristics and the package leaflet.
Estonian: Forsteo omaduste kokkuvõttesse ja pakendi infolehele lisati ravimi ohutu ja tõhusa kasutamise teave, kus on ka tervishoiuspetsialistide ja patsientide võetavad meetmed.
English: It acts like the hormone to stimulate bone formation by acting on osteoblasts (bone-forming cells).
Estonian: Toimeaine toimib samal viisil kui see hormoon, mõjutades osteoblaste (luukude moodustavaid rakke) ning stimuleerides nii luukoe teket.
English: • women who have been through the menopause.
Estonian: • menopausijärgses eas naised.
English: The third study compared the effects of Forsteo and alendronate (another medicine used to treat osteoporosis) on spine bone density over three years.
Estonian: Kolmandas uuringus võrreldi enam kui kolme aasta kestel Forsteo ja alendronaadi (samuti osteoporoosiravim) toimet lülisamba luutihedusele.
English: An additional study looked at the effects of Forsteo on bone density over two years in 234 women who had been through the menopause.
Estonian: Lisauuringus uuriti kahe aasta kestel Forsteo toimet luutihedusele 234 menopausijärgses eas naisel.
English: The second study looked at the use of Forsteo in 437 men with osteoporosis, comparing its effect on the density of bones in the spine with that of placebo.
Estonian: Teises uuringus vaadeldi Forsteo kasutamist 437 osteoporoosiga mehel: võrreldi ravimi ja platseebo toimet lülisamba luutihedusele.
English: For the full list of all side effects reported with Forsteo, see the package leaflet.
Estonian: Forsteo kohta teatatud kõrvalnähtude täielik loetelu on pakendi infolehel.
English: What benefit has Forsteo shown during the studies?
Estonian: Milles seisneb uuringute põhjal Forsteo kasulikkus?
English: What is Forsteo used for?
Estonian: Milleks Forsteot kasutatakse?
English: How is Forsteo used?
Estonian: Kuidas Forsteot kasutatakse?
English: It also reduced the risk of non-vertebral fractures by 62%, but did not reduce the risk of hip fractures.
Estonian: Forsteo vähendas ka muude luumurdude (v.a puusamurdude) riski 62%.
English: How does Forsteo work?
Estonian: Kuidas Forsteo toimib?
English: Forsteo was more effective than placebo in reducing vertebral fractures: 5% of the women who received Forsteo had a new fracture during the study, compared with 14% in the group who received placebo.
Estonian: Forsteo oli lülisambamurdude arvu vähendamisel efektiivsem kui platseebo: Forsteot saanud naistest esines uuringu kestel uusi murde 5%-l ja platseebot saanutest 14%-l. Forsteo vähendas 19-kuulise uuringu kestel uue lülisambamurru riski platseeboga võrreldes 65%.
English: How has Forsteo been studied?
Estonian: Kuidas Forsteot uuriti?
English: The medicine can only be obtained with a prescription.
Estonian: Forsteo on retseptiravim.
English: A user manual is available for the pen.
Estonian: Pensüstlal on kaasas kasutusjuhend.
English: It can be very serious.
Estonian: See võib olla väga tõsine.
English: This could be dangerous to yourself or others.
Estonian: See võib osutuda ohtlikuks nii teile kui teistele.
English: Be especially aware of the following:
Estonian: Olge eriti tähelepanelik järgmistel juhtudel:
English: ATC code: A10AE06.
Estonian: ATC kood: A10AE06.
English: 6 seconds
Estonian: 6 sekundit
English: The signs of a serious allergic reaction are:
Estonian: Tõsise allergilise reaktsiooni tunnused on:
English: • not give you any food or drink because you may choke.
Estonian: • ei tohi anda teile süüa ega juua, kuna võite lämbuda.
English: Time since injection (hours) Treatment
Estonian: Aeg alates süstimisest (tunnid) Ravi
English: Your medicine might be harmful to their health.
Estonian: Teie ravim võib kahjustada nende tervist.
English: • Do not leave the pen in a car or other place where it can get too hot or too cold.
Estonian: • Ärge jätke pen-süstlit autosse või mujale, kus võib minna liiga kuumaks või külmaks.
English: 4 Episodes from week 16 in each treatment period
Estonian: 4 Episoodid alates 16. nädalast igas raviperioodis
English: Insulin requirements usually decrease in the first trimester and increase subsequently during the second and third trimesters.
Estonian: Tavaliselt väheneb insuliinivajadus esimese trimestri jooksul ja suureneb teisel ning kolmandal trimestril.
English: Before first use
Estonian: Enne esmakordset kasutust
English: CI: 95% confidence interval.
Estonian: CI - 95% usaldusvahemik.
English: If you try to put it back on, you may accidentally stick yourself with the needle.
Estonian: Kui üritate seda tagasi asetada, võite end nõelaga kogemata torgata.
English: • the local reactions spread to other parts of your body
Estonian: • paiksete reaktsioonide levimine muudele kehaosadele;
English: This may constitute a risk in situations where these abilities are of special importance (e.g. driving a car or using machines).
Estonian: See asjaolu võib põhjustada ohtu olukorras, kus need omadused on eriti tähtsad (nt auto juhtimine või masinate käsitsemine).
English: Date of latest renewal: 21 September 2017
Estonian: Müügiloa viimase uuendamise kuupäev: 21. september 2017
English: • how much Tresiba you will need each day
Estonian: • kui palju Tresiba't iga päev vajate;
English: EAC: Event adjudication committee.
Estonian: EAC (Event adjudication committee) - kõrvaltoimete hindamise komitee.
English: Any waste material should be disposed of in accordance with local requirements.
Estonian: Kasutamata jäätmematerjal tuleb hävitada vastavalt kohalikele nõuetele.
English: Subsequently, dosage should be adjusted individually.
Estonian: Seejärel tuleb annust kohandada individuaalselt.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 21 January 2013
Estonian: ESMASE MÜÜGILOA VÄLJASTAMISE/MÜÜGILOA UUENDAMISE KUUPÄEV Müügiloa esmase väljastamise kuupäev: 21. jaanuar 2013
English: Detailed instructions for use are provided on the other side of this leaflet.
Estonian: Üksikasjalikud kasutamisjuhised on toodud käesoleva infolehe teisel küljel.
English: After first opening: Do not refrigerate.
Estonian: Pärast esmast avamist: Mitte hoida külmkapis.
English: If you drink alcohol, your need for insulin may change.
Estonian: Kui joote alkoholi, võib teie insuliinivajadus muutuda.
English: Patients should be instructed to always use a new needle.
Estonian: Patsiente tuleb õpetada kasutama alati uut nõela.
English: Tresiba is to be dosed in accordance with the individual patient's needs.
Estonian: Tresiba't tuleb annustada vastavalt individuaalse patsiendi vajadustele.
English: Adverse reactions listed below are based on clinical trial data and classified according to MedDRA System Organ Class.
Estonian: Allpool loetletud kõrvaltoimed põhinevad kliiniliste uuringute andmetel ja on klassifitseeritud vastavalt MedDRA-organsüsteemi klassidele.
English: If you have poor eyesight, please see section 3.
Estonian: Kui olete vaegnägija, siis vaadake lõiku 3.
English: This is normal and does not affect your dose.
Estonian: See on normaalne ega mõjuta annust.
English: For storage conditions after first opening of the medicinal product, see section 6.3.
Estonian: Säilitamistingimused pärast ravimpreparaadi esmast avamist, vt lõik 6.3.
English: • Please also read the manual that comes with your insulin delivery system.
Estonian: • Palun lugege läbi ka insuliinisüstevahendiga kaasasolnud juhend.
English: This is normal, but you must still check the insulin flow.
Estonian: See on normaalne, aga insuliinivoolu tuleb endiselt kontrollida.
English: • Caregivers must be very careful when handling used needles to reduce the risk of needle injury and cross-infection.
Estonian: • Hooldajad peavad olema kasutatud nõelte käsitsemisel väga ettevaatlikud, et vähendada vigastuse ja ristnakatumise riski.
English: Avoidance of medication errors
Estonian: Ravimiga seotud eksituste vältimine
English: This medicinal product must not be mixed with any other medicinal products.
Estonian: Seda ravimpreparaati ei tohi segada ühegi teise ravimiga.
English: Dose counter stopped: 52 units left
Estonian: Annuse loendur peatus: 52 ühikut on alles
English: • anabolic steroids, such as testosterone
Estonian: • anaboolseid steroide nagu testosteroon;
English: Other medicines and Tresiba
Estonian: Muud ravimid ja Tresiba
English: IDeg 0.6 units/kg
Estonian: IDeg 0,6 Ü/kg
English: After first opening: Use within 8 weeks
Estonian: Pärast esmast avamist: kasutada 8 nädala jooksul.
English: Talk to your doctor.
Estonian: Rääkige sellest oma arstiga.
English: Adjustment of dose may be necessary if patients undertake increased physical activity, change their usual diet or during concomitant illness.
Estonian: Annuse kohandamine võib olla vajalik ka siis, kui patsiendid suurendavad oma füüsilist aktiivsust, muudavad oma tavalist dieeti või kaasneva haiguse ajal.
English: How to inject
Estonian: Kuidas süstida
English: Do not use the pen without proper training from your doctor or nurse.
Estonian: Ärge kasutage pen-süstlit ilma arsti või meditsiiniõe poolse korraliku väljaõppeta.
English: This medicinal product can be used in adolescents and children from the age of 1 year (see section 5.1).
Estonian: Seda ravimit võib kasutada noorukitel ja lastel pärast esimest eluaastat (vt lõik 5.1).
English: You may stick yourself with the needle.
Estonian: Võite end nõelaga torgata.
English: Your insulin dose may need to be changed during pregnancy and after delivery.
Estonian: Teie insuliiniannus võib vajada raseduse ajal ja pärast sünnitust muutmist.
English: • turn you on your side
Estonian: • pöörama teid külili;
English: Safety and efficacy have been demonstrated in a long term trial in children aged 1 to less than 18 years.
Estonian: Pikaajalised uuringud on näidanud ohutust ja tõhusust 1 kuni 18 aastastel lastel.
English: Usual warning symptoms may disappear in patients with long-standing diabetes.
Estonian: Tavalised hoiatavad sümptomid võivad kaduda pikka aega diabeeti põdenud patsientidel.
English: • Change the place within the area where you inject each day to reduce the risk of developing lumps and skin pitting (see section 4).
Estonian: • Muutke iga päev kohta, kuhu süstite, et vähendada tükkide tekke ja naha armistumise riski (vt lõik 4).
English: Tresiba with alcohol
Estonian: Tresiba ja alkohol
English: This medicinal product has no or negligible influence on the ability to drive and use machines.
Estonian: See ravim ei mõjuta või mõjutab ebaoluliselt autojuhtimise ja masinate käsitsemise võimet.
English: • sulfonamides, for infections
Estonian: • sulfoonamiide - infektsioonide vastu;
English: The ratio between AUCGIR,0-12h,SS and AUCGIR,τ,SS was 0.5.
Estonian: Suhe AUCGIR, 0-12 h, SS ja AUCGIR, τ, SS vahel oli 0,5.
English: Important information Pay special attention to these notes as they are important for correct use of the pen.
Estonian: Pöörake neile märkustele erilist tähelepanu, kuna need on pen-süstli õigeks kasutamiseks olulised.
English: This means that the medicine is essentially ‘sodium-free'.
Estonian: See tähendab, et ravim on sisuliselt naatriumivaba.
English: • If you need more insulin than the units left in your pen, you can split your dose between two pens.
Estonian: • Kui vajate enam insuliini kui pen-süstlisse ühikuid jäänud on, võite jagada annuse kahe pensüstli vahel.
English: Some medicines affect your blood sugar level, this may mean your insulin dose has to be changed.
Estonian: Mõned ravimid mõjutavad teie veresuhkru taset - see võib tähendada, et teie insuliiniannust tuleb muuta.
English: • Get medical help straight away.
Estonian: • Otsige viivitamatult arstiabi.
English: However, the patient's ability to concentrate and react may be impaired as a result of hypoglycaemia.
Estonian: Siiski võib patsiendi keskendumis- ja reageerimisvõime hüpoglükeemia tulemusel väheneda.
English: Hazard Ratio (95% CI)
Estonian: Riski suhe (95% CI)
English: Talk to your doctor if:
Estonian: Rääkige oma arstile, kui:
English: • Eat glucose tablets or another high sugar snack, like sweets, biscuits or fruit juice (always carry glucose tablets or a high sugar snack, just in case).
Estonian: • Sööge glükoositablette või muud rohkesti suhkrut sisaldavat toitu nagu maiustused, küpsised või puuviljamahl (igaks juhuks kandke alati kaasas glükoositablette või rohkesti suhkrut sisaldavat toitu).
English: If there is still no drop, change the needle and repeat steps 2A to 2C once more.
Estonian: Kui tilka endiselt ei ilmu, vahetage nõel välja ja korrake etappe 2A kuni 2C veelkord.
English: • growth hormone, for growth hormone deficiency
Estonian: • kasvuhormooni - kasvuhormooni defitsiidi korral;
English: Tresiba must not be drawn from the cartridge of the pre-filled pen into a syringe (see section 4.4).
Estonian: Tresiba't ei tohi pen-süstlis olevast kolbampullist tõmmata süstlasse (vt lõik 4.4).
English: • Always follow your doctor's recommendation for dose.
Estonian: • Annustamisel järgige alati oma arsti soovitusi.
English: Clear, colourless, neutral solution.
Estonian: Selge värvitu neutraalne lahus.
English: • Use Tresiba once each day, preferably at the same time every day.
Estonian: • Kasutage Tresiba't kord päevas, eelistatult iga päev samal ajal.