FrancophonIA/ELRC3.0 huggingface dataset:
English: Dose (maximum dose per day) Original starting dose
Croatian: Doza (maksimalna dnevna doza) Prvobitna početna doza
English: This should be taken into account in patients with diabetes mellitus.
Croatian: To treba uzeti u obzir u bolesnika sa šećernom bolešću.
English: Therefore, caution should be recommended when driving a car or operating machines.
Croatian: Stoga se mora preporučiti oprez pri upravljanju vozilima i radu na strojevima.
English: # DEATHS / # Land Patient
Croatian: # SMRTI / # bolesnika
English: Instructions for administration to the patient
Croatian: Upute za primjenu bolesniku
English: Renal changes in monkeys treated for up to 9 months were limited to an increase in background kidney mineralisation.
Croatian: Bubrežne promjene u majmuna liječenih do 9 mjeseci bile su ograničene na porast pozadinske mineralizacije u bubrezima.
English: Certain medicines may interfere with the effect of SPRYCEL when taken together.
Croatian: Određeni lijekovi mogu utjecati na djelovanje lijeka SPRYCEL ako se uzimaju istodobno.
English: • 1 SPRYCEL oral suspension bottle containing a white to yellow opaque suspension.
Croatian: • 1 bocu SPRYCEL oralne suspenzije koja sadrži bijelu do žutu neprozirnu suspenziju
English: What SPRYCEL contains
Croatian: Što SPRYCEL sadrži
English: If PAH is confirmed, dasatinib should be permanently discontinued.
Croatian: Ako se potvrdi PAH, primjena dasatiniba mora se trajno prekinuti.
English: Results described below are based on a minimum of 2 years and 7 years follow-up after the start of dasatinib therapy.
Croatian: Niže navedeni rezultati temelje se na podacima nakon najmanje 2 godine i 7 godina praćenja od početka liječenja dasatinibom.
English: ANC: absolute neutrophil count *lower tablet dose not available
Croatian: ABN: apsolutni broj neutrofila *nije dostupna tableta u nižoj dozi
English: Depending on how you respond to the treatment, your doctor may suggest a higher or lower dose, or even stopping treatment briefly.
Croatian: Ovisno o odgovoru na liječenje, liječnik Vam može preporučiti višu ili nižu dozu ili čak nakratko prekinuti liječenje.
English: The random inter-occasion variability in exposure is not expected to affect the cumulative exposure and efficacy or safety.
Croatian: Ne očekuje se da će ta nasumična intraindividualna varijabilnost u izloženosti u pojedinim vremenskim točkama utjecati na kumulativnu izloženost te djelotvornost ili sigurnost.
English: If you or your child could be allergic, ask your doctor for advice.
Croatian: U slučaju da biste Vi ili Vaše dijete mogli biti alergični, potražite savjet svoga liječnika.
English: In patients, dasatinib has a large apparent volume of distribution (2,505 L), coefficient of variation (CV% 93%), suggesting that the medicinal product is extensively distributed in the extravascular space.
Croatian: Dasatinib u bolesnika ima velik prividni volumen distribucije (2505 l) i koeficijent varijacije (CV% 93%), što ukazuje na to da se lijek široko raspodjeljuje u ekstravaskularnom prostoru.
English: Refer to the package leaflet for more detailed instructions for use.
Croatian: Vidjeti uputu o lijeku za detaljnije upute za uporabu.
English: Film-coated tablets should not be dispersed as the exposure in patients receiving a dispersed tablet is lower than in those swallowing a whole tablet.
Croatian: Filmom obložene tablete ne smiju se otapati jer je izloženost lijeku u bolesnika koji uzmu rastopljenu tabletu manja nego u onih koji progutaju cijelu tabletu.
English: However, when antacids were administered 2 hours prior to a single dose of SPRYCEL, no relevant changes in dasatinib concentration or exposure were observed.
Croatian: Međutim, kad su antacidi bili primijenjeni 2 sata prije pojedinačne doze lijeka SPRYCEL, nisu bile opažene nikakve značajne promjene u koncentraciji dasatiniba ili izloženosti dasatinibu.
English: Dasatinib and its metabolites are minimally excreted via the kidney.
Croatian: Dasatinib i njegovi metaboliti minimalno se izlučuju putem bubrega.
English: SPRYCEL tablets can be taken with or without a meal.
Croatian: SPRYCEL tablete mogu se uzimati uz obrok ili bez njega.
English: In people with ALL, white cells called lymphocytes multiply too quickly and live too long.
Croatian: U osoba s ALL, bijele krvne stanice koje se zovu limfociti prebrzo se množe i predugo žive.
English: For storage conditions after constitution of the medicinal product, see section 6.3.
Croatian: Za uvjete čuvanja nakon rekonstitucije lijeka vidjeti dio 6.3.
English: Grade 3 or 4 pleural effusion may require thoracocentesis and oxygen therapy.
Croatian: Pleuralni izljev stupnja 3. ili 4. može zahtijevati izvođenje torakocenteze i terapiju kisikom.
English: Results are shown in Table 15.
Croatian: Rezultati su prikazani u Tablici 15.
English: Pharmacotherapeutic group: antineoplastic agents, protein kinase inhibitors, ATC code: L01XE06
Croatian: Farmakoterapijska skupina: antineoplastički lijekovi, inhibitori protein kinaze, ATK oznaka: L01XE06
English: In general, there was no association of decreased calcium with clinical symptoms.
Croatian: Općenito, snižene vrijednosti kalcija nisu bile povezane s kliničkim simptomima.
English: No studies have been performed to evaluate dasatinib interaction with other protein-bound medicinal products.
Croatian: Nisu provedena ispitivanja kojima bi se mogle utvrditi interakcije dasatiniba s lijekovima vezanima na proteine.
English: Accelerated phase CML
Croatian: Faza ubrzanja KML
English: Efficacy results are presented in Tables 12 and 13.
Croatian: Rezultati djelotvornosti prikazani su u Tablicama 12 i 13.
English: The pharmacokinetics of dasatinib were evaluated in 229 adult healthy subjects and in 84 patients.
Croatian: Farmakokinetika dasatiniba ispitana je u 229 zdravih odraslih ispitanika i 84 bolesnika.
English: • If the amount needed is greater than 11 mL, it must be split into 2 doses as shown below:
Croatian: • Ako je potrebna količina veća od 11 ml, mora se podijeliti na 2 doze, kako je navedeno u nastavku:
English: When this rate was based on the 85 patients with evaluable Ig/TCR assessments, the estimate was 89.4%.
Croatian: Kad se ta stopa izračunavala na temelju 85 bolesnika u kojih su se mogli ocijeniti podaci za Ig/TCR, procijenjena je na 89,4%.
English: If marrow cellularity is >10%, resumption of treatment with SPRYCEL may be considered.
Croatian: Ako je celularnost koštane srži > 10%, može se razmotriti nastavak liječenja lijekom SPRYCEL.
English: ALLOW TO AIR DRY AFTER EACH USE
Croatian: NAKON SVAKE UPORABE OSTAVITI DA SE OSUŠI NA ZRAKU
English: This is because SPRYCEL could cause hepatitis B to become active again, which can be fatal in some cases.
Croatian: To je potrebno jer SPRYCEL može uzrokovati ponovnu aktivaciju hepatitisa B što u nekim slučajevima može rezultirati smrtnim ishodom.
English: With the patient in an upright position, place the tip of the syringe into the mouth between the side of the mouth and the tongue.
Croatian: Dok je bolesnik u uspravnom položaju, stavite mu vrh štrcaljke između ruba usta i jezika.
English: Outer Carton: 2D barcode carrying the unique identifier included.
Croatian: Kutija: Sadrži 2D barkod s jedinstvenim identifikatorom.
English: It can be taken with or without a meal and should be taken consistently either in the morning or in the evening (see section 5.2).
Croatian: Može se uzeti uz obrok ili bez njega, ali se mora uzimati uvijek dosljedno ili ujutro ili navečer (vidjeti dio 5.2).
English: At the request of the European Medicines Agency, Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: Ažurirani RMP treba dostaviti: na zahtjev Europske agencije za lijekove; prilikom svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: There was no significant difference of dasatinib PK between children and adolescents.
Croatian: Nije bilo značajne razlike u farmakokinetici dasatiniba između djece i adolescenata.
English: Durability of response and estimated survival rates provide additional evidence of dasatinib clinical benefit.
Croatian: Trajnost odgovora i procjena stope preživljenja dodatni su dokazi povoljnog kliničkog djelovanja dasatiniba.
English: SPRYCEL inhibits the growth of these leukaemic cells.
Croatian: SPRYCEL sprječava rast tih leukemijskih stanica.
English: However, in an in vivo single-dose study in conscious telemetered monkeys, there were no changes in QT interval or ECG wave form.
Croatian: Međutim, u telemetrijskom ispitivanju in vivo pojedinačne doze u budnih majmuna nije bilo promjena u QT intervalu ili obliku EKG valova.
English: Do not take medicines that neutralise stomach acids (antacids such as aluminium hydroxide or magnesium hydroxide) in the 2 hours before or 2 hours after taking SPRYCEL.
Croatian: Ne uzimajte lijekove koji neutraliziraju kiselinu u želucu (antacidi poput aluminijevog hidroksida ili magnezijevog hidroksida) 2 sata prije ili 2 sata poslije uzimanja lijeka SPRYCEL.
English: How long to take SPRYCEL
Croatian: Koliko dugo uzimati SPRYCEL
English: a Confirmed complete cytogenetic response (cCCyR) is defined as a response noted on two consecutive occasions (at least
Croatian: Potvrđen potpuni citogenetski odgovor (cCCyR) definira se kao odgovor zabilježen na dva uzastopna pregleda (u razmaku od najmanje 28 dana).
English: For oral use after constitution.
Croatian: Primjena kroz usta nakon rekonstitucije.
English: Women of childbearing potential/contraception in males and females Both sexually active men and women of childbearing potential should use effective methods of contraception during treatment.
Croatian: Žene u reproduktivnoj dobi/kontracepcija u muškaraca i žena Muškarci i žene u reproduktivnoj dobi koji su spolno aktivni trebaju koristiti učinkovite metode kontracepcije tijekom liječenja.
English: Common depression, insomnia
Croatian: Često depresija, nesanica
English: Rare aplasia pure red cell
Croatian: Rijetko aplazija čiste crvene krvne loze
English: In rats, minimal to mild decreases in erythrocyte parameters were accompanied by bone marrow changes; similar changes occurred in monkeys at a lower incidence.
Croatian: U štakora su minimalna do umjerena smanjenja parametara eritrocita bila praćena promjenama u koštanoj srži; slične promjene nastupile su u majmuna, ali uz nižu incidenciju.
English: Data was pooled across two studies and showed that dasatinib was rapidly absorbed.
Croatian: Podaci su objedinjeni iz dvaju ispitivanja, a pokazali su da se dasatinib brzo apsorbira.
English: In vitro data indicate a potential risk for interaction with CYP2C8 substrates, such as glitazones.
Croatian: Podaci iz ispitivanja in vitro pokazuju da postoji i potencijalni rizik od interakcije sa supstratima CYP2C8, kao što su glitazoni.
English: Ask your doctor or pharmacist for advice if you are pregnant or breast feeding.
Croatian: Pitajte svog liječnika ili ljekarnika za savjet ako ste trudni ili dojite.
English: These effects occurred at doses that did not produce maternal toxicity, indicating that dasatinib is a selective reproductive toxicant from implantation through the completion of organogenesis.
Croatian: Ti su se učinci javili pri dozama koje nisu imale toksične učinke na majku, što znači da dasatinib ima selektivne toksične učinke na reprodukciju od faze implantacije do završetka organogeneze.
English: Following resolution of the first episode, reintroduction of dasatinib at the same dose level should be considered.
Croatian: Nakon povlačenja prve epizode, treba razmotriti ponovno uvođenje dasatiniba u istoj dozi.
English: • If the amount needed is greater than 11 mL, it must be split into 2 doses as indicated in Table 16.
Croatian: • Ako je potrebna količina veća od 11 ml, mora se podijeliti na 2 doze, kako je navedeno u Tablici
English: In mice, dasatinib induced immunosuppression, which was dose-related and effectively managed by dose reduction and/or changes in dosing schedule.
Croatian: U miševa je dasatinib izazivao imunosupresiju, koja je ovisila o dozi i učinkovito se rješavala smanjenjem doze i/ili promjenama u rasporedu doziranja.
English: During the consolidation blocks of chemotherapy, CBCs should be performed every 2 days until recovery (see sections 4.2 and 4.8).
Croatian: Tijekom konsolidacijskih blokova kemoterapije kompletnu krvnu sliku treba raditi svaka 2 dana do oporavka (vidjeti dijelove 4.2 i 4.8).
English: Caution should be exercised if patients are required to take medicinal products that inhibit platelet function or anticoagulants.
Croatian: Nužno je biti na oprezu ako bolesnici moraju uzimati lijekove koji inhibiraju funkciju trombocita ili antikoagulanse.
English: SPRYCEL powder for oral suspension is to be constituted as follows: Note: If you have to constitute more than one bottle, complete one bottle at a time.
Croatian: SPRYCEL prašak za oralnu suspenziju treba rekonstituirati na sljedeći način: Napomena: Ako morate rekonstituirati sadržaj više od jedne boce, rekonstituirajte jednu po jednu bocu.
English: The outcome of patients with bone marrow transplantation after dasatinib treatment has not been fully evaluated.
Croatian: Ishod bolesnika s transplantacijom koštane srži nakon liječenja dasatinibom nije još u potpunosti ocijenjen.
English: • Shake well before each use.
Croatian: • Dobro je protresite prije svake primjene.
English: Efficacy was also assessed in patients who were intolerant to imatinib.
Croatian: Djelotvornost se ocjenjivala i u bolesnika koji nisu podnosili imatinib.
English: The time to MMR is displayed graphically in Figure 1.
Croatian: Vrijeme do MMR grafički je prikazano na Slici 1.
English: Remind the patient or caregiver to shake the bottle vigorously prior to each use.
Croatian: Podsjetite bolesnika ili njegovatelja da mora snažno protresti bocu prije svake primjene.
English: CYP3A4 is a major enzyme responsible for the metabolism of dasatinib.
Croatian: CYP3A4 je glavni enzim za metabolizam dasatiniba.
English: If you have accidentally taken too many tablets, talk to your doctor immediately.
Croatian: Ako ste slučajno uzeli previše tableta, odmah se javite liječniku.
English: Time-to cCCyR Time-to MMR Durability of cCCyR
Croatian: Vrijeme do cCCyR Vrijeme do MMR Trajanje cCCyR
English: These 6 cases included cases of epiphyses delayed fusion, osteopaenia, growth retardation, and gynecomastia (see section 5.1).
Croatian: Tih 6 slučajeva uključivalo je slučajeve kasnog srastanja epifize, osteopenije, zastoja u rastu i ginekomastije (vidjeti dio 5.1).
English: Since dasatinib is associated with grade 3 or 4 myelosuppression (see section 4.4), patients who ingest more than the recommended dose should be closely monitored for myelosuppression and given appropriate supportive treatment.
Croatian: Budući da je dasatinib povezan s mijelosupresijom 3. ili 4. stupnja (vidjeti dio 4.4), bolesnici koji uzmu dozu veću od preporučene moraju biti strogo nadzirani zbog moguće mijelosupresije i primiti odgovarajuću potpornu terapiju.
English: Hypokalaemia or hypomagnesaemia should be corrected prior to dasatinib administration.
Croatian: Hipokalijemija ili hipomagnezijemija moraju se korigirati prije primjene dasatiniba.
English: Pregnant or breast-feeding women should avoid exposure to SPRYCEL powder for oral suspension.
Croatian: Trudnice i dojilje trebaju izbjegavati izlaganje SPRYCEL prašku za oralnu suspenziju.
English: Disease progression was defined as increasing white blood cells despite appropriate therapeutic management, loss of CHR, partial CyR or CCyR, progression to accelerated phase or blast phase, or death.
Croatian: Progresija bolesti bila je definirana kao povećanje broja bijelih krvnih stanica unatoč odgovarajućem terapijskom liječenju, gubitak CHR, djelomični CyR ili CCyR, napredovanje u ubrzanu fazu ili blastnu fazu ili smrt.
English: The film-coated tablets must not be crushed, cut or chewed in order to maintain dosing consistency and minimise the risk of dermal exposure; they must be swallowed whole.
Croatian: Filmom obložene tablete ne smiju se drobiti, rezati niti žvakati, kako bi se održala dosljednost doziranja i smanjio rizik dodira s kožom; moraju se progutati cijele.
English: Patients with mild, moderate or severe hepatic impairment may receive the recommended starting dose.
Croatian: Bolesnici s blagim, umjerenim ili teškim oštećenjem jetre mogu primiti preporučenu početnu dozu.
English: Make sure the second bottle is shaken before use.
Croatian: Obavezno protresite drugu bocu prije uporabe.
English: Histamine-2 antagonists and proton pump inhibitors
Croatian: Antagonisti histaminskih H2 receptora i inhibitori protonske pumpe
English: Since the renal clearance of dasatinib and its metabolites is < 4%, a decrease in total body clearance is not expected in patients with renal insufficiency.
Croatian: Budući da je bubrežni klirens dasatiniba i njegovih metabolita <4%, u bolesnika s bubrežnom insuficijencijom ne očekuje se smanjenje ukupnog klirensa iz tijela.
English: Thrombotic microangiopathy (TMA)
Croatian: Trombotska mikroangiopatija (TMA)
English: Thirty-eight percent of patients had baseline mutations known to confer imatinib resistance.
Croatian: Trideset i osam posto bolesnika imalo je osnovne mutacije za koje se zna da uzrokuju otpornost na imatinib.
English: Step 1: Tap bottom of each bottle (containing 33 g SPRYCEL powder for oral suspension) gently to loosen the powder.
Croatian: 1. korak: Nježno lupnite dno svake boce (koja sadrži 33 g SPRYCEL praška za oralnu suspenziju) da bi se prašak rastresao.
English: Changes in the gastrointestinal, haematopoietic and lymphoid systems were reversible following cessation of treatment.
Croatian: Promjene u probavnom, hematopoetskom i limfnom sustavu bile su reverzibilne i povukle su se nakon prestanka liječenja.
English: Slowly withdraw the amount of SPRYCEL oral suspension prescribed by pulling the syringe plunger until it reaches the marking of the dose prescribed.
Croatian: Polako izvucite propisanu količinu SPRYCEL oralne suspenzije povlačenjem klipa štrcaljke do oznake koja označava propisanu dozu.
English: The MRD negativity rates at the end of induction and consolidation as measured by flow cytometry were 66.0% and 84.0%, respectively.
Croatian: Stopa negativnih nalaza na MRD na kraju indukcije i konsolidacije izmjerena protočnom citometrijom iznosila je 66,0% odnosno 84,0%.
English: Paediatric patients with CML
Croatian: Pedijatrijski bolesnici s KML
English: If you could be allergic, ask your doctor for advice.
Croatian: U slučaju da biste mogli biti alergični, potražite savjet svoga liječnika.
English: ______ Dasatinib 100 mg once daily --------- Imatinib 400 mg once daily
Croatian: ______ Dasatinib 100 mg jedanput dnevno --------- Imatinib 400 mg jedanput dnevno
English: Use of SPRYCEL is not recommended during pregnancy.
Croatian: Ne preporučuje se primjena lijeka SPRYCEL tijekom trudnoće.
English: Powder for oral suspension 5 to less than 10
Croatian: Prašak za oralnu suspenziju od 5 do manje od 10 kg
English: Similar rates of mutation were observed in both the treatment arms.
Croatian: Zabilježene su slične stope mutacija u obje skupine bolesnika.
English: The 140 mg once daily regimen showed a comparable efficacy profile to the 70 mg twice daily regimen but a more favourable safety profile.
Croatian: Režim liječenja dozom od 140 mg jedanput dnevno pokazao je sličan profil djelotvornosti kao i režim liječenja dozom od 70 mg dvaput dnevno, ali je imao povoljniji profil sigurnosti.
English: For third episode, further reduce dose to 50 mg once daily (for newly diagnosed patients) or discontinue (for patients resistant or intolerant to prior therapy including imatinib).
Croatian: Kod treće epizode potrebno je daljnje smanjenje doze na 50 mg jedanput dnevno (za novodijagnosticirane bolesnike) ili prekidanje terapije (u bolesnika koji ne podnose ili su otporni na prethodnu terapiju uključujući imatinib).
English: Cardiac adverse reactions were more frequent in patients with risk factors or a history of cardiac disease.
Croatian: Srčane nuspojave bile su češće u bolesnika s rizičnim faktorima ili srčanom bolešću u anamnezi.
English: Remove the syringe from the bottle being careful not to depress the plunger.
Croatian: Izvucite štrcaljku iz boce, pazeći da pritom ne pritisnete klip.
English: Refer to the package leaflet (see section 5 ‘How to store SPRYCEL') for instructions on discarding any unused medicine, syringe and bottle.
Croatian: Pogledajte uputu o lijeku (dio 5. ‘Kako čuvati SPRYCEL') za upute o zbrinjavanju neupotrijebljenog lijeka, štrcaljke i boce.
English: Dasatinib is associated with fluid retention.
Croatian: Dasatinib je povezan sa zadržavanjem tekućine.
English: Benzoic acid/Benzoate salt may increase jaundice (yellowing of the skin and eyes) in newborn babies (up to 4 weeks old).
Croatian: Benzoatna kiselina/sol benzoatne kiseline može pojačati žuticu (žutilo kože i očiju) u novorođenčadi (do 4 tjedna starosti).
English: This may be a sign of damage to blood vessels known as thrombotic microangiopathy (TMA).
Croatian: To može biti znak oštećenja krvnih žila koje se zove trombotična mikroangiopatija (TMA).
English: Plasma concentration and measured in vitro activity indicate that metabolites of dasatinib are unlikely to play a major role in the observed pharmacology of the product.
Croatian: Koncentracija u plazmi i aktivnost izmjerena in vitro pokazuju da metaboliti dasatiniba najvjerojatnije ne igraju veliku ulogu u opaženoj farmakologiji lijeka.
English: Warnings and precautions Talk to your doctor or pharmacist before using SPRYCEL if you are taking medicines to thin the blood or prevent clots (see "Other medicines and SPRYCEL")
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku ili ljekarniku prije nego uzmete SPRYCEL ako uzimate lijekove za razrjeđivanje krvi ili sprječavanje stvaranja krvnih ugrušaka (pogledajte dio
English: Median duration of treatment was approximately 6 months (range 0.03-31 months).
Croatian: Medijan trajanja liječenja iznosio je oko 6 mjeseci (raspon, 0,03-31 mjeseci).
English: The highest overdose of 280 mg per day for one week was reported in two patients and both developed a significant decrease in platelet counts.
Croatian: Najveće predoziranje od 280 mg dnevno tijekom jednog tjedna prijavljeno je u dva bolesnika u kojih je potom nastupilo značajno smanjenje broja trombocita.
English: Other medicines and SPRYCEL Tell your doctor if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: If you are pregnant or think you may be pregnant, tell your doctor immediately.
Croatian: Ako ste trudni ili mislite da biste mogli biti trudni, odmah o tome obavijestite liječnika.
English: a Numbers in bold font are the results of primary endpoints.
Croatian: a Masno otisnute znamenke pokazuju rezultate za primarne ishode.
English: Additionally, dasatinib inhibits SRC family kinases at subnanomolar concentrations.
Croatian: Dodatno, dasatinib inhibira obitelj SRC kinaza pri subnanomolarnim koncentracijama.
English: Before you prepare a dose of SPRYCEL oral suspension for administration to the patient, get the following supplies ready:
Croatian: Prije nego što pripremite dozu SPRYCEL oralne suspenzije za primjenu bolesniku, pripremite sljedeći pribor:
English: The highest dose resulted in a plasma exposure (AUC) level generally equivalent to the human exposure at the recommended range of starting doses from 100 mg to 140 mg daily.
Croatian: Pri najvišoj dozi razina izloženosti lijeku u plazmi (AUC) općenito je odgovarala izloženosti čovjeka pri preporučenom rasponu početne doze od 100 mg do 140 mg.