FrancophonIA/ELRC3.0 huggingface dataset:
English: Close monitoring for signs of rilpivirine toxicity and possibly also dose adjustment of rilpivirine is recommended when coadministered with Aptivus/ritonavir.
Danish: rilpivirin-toksicitet og muligvis også justering af rilpivirindosis anbefales ved samtidig administration af Aptivus/ritonavir og rilpivirin
English: Your child's doctor will monitor their liver function by blood tests before and during Aptivus treatment.
Danish: Dit barns læge vil tage blodprøver for at undersøge leverfunktionen, før dit barn starter på Aptivus-behandlingen og under behandlingen.
English: Didanosine 200 mg BID, ≥ 60 kg (TPV/r 250/200 mg BID) - 125 mg BID, < 60 kg (TPV/r 750/100 mg BID)
Danish: Didanosin 200 mg x 2, ≥ 60 kg (TPV/r 250/200 mg x 2) - 125 mg x 2, < 60 kg (TPV/r 750/100 mg x 2)
English: Of note, patients in the RESIST studies had a specific mutational pattern at baseline of at least one primary protease gene mutation among codons 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V or 90M, and no more than two mutations on codons 33, 82, 84 or 90.
Danish: Det skal bemærkes, at patienterne i RESIST-studierne udviste et specifikt mutationsmønster ved baseline på mindst én primær proteasegenmutation blandt kodon 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V eller 90M og højst 2 mutationer ved kodon 33, 82, 84 eller 90.
English: S-methadone Cmax ↓ 62% S-methadone AUC ↓ 63%
Danish: S-metadon Cmax ↓ 62% S-metadon AUC ↓ 63%
English: Co-administration of colchicine with Aptivus/ritonavir in patients with renal or hepatic impairment (see section 4.5).
Danish: Samtidig administration af colchicin og Aptivus/ritonavir hos patienter med nedsat nyre- eller leverfunktion (se pkt.
English: Other medicines with which Aptivus may interact include: - oral contraceptives/hormone replacement therapy (HRT): If your child is taking the contraceptive pill to prevent pregnancy they should use an additional or different type of contraception (e.g. barrier contraception like condoms).
Danish: Anden medicin, som Aptivus kan påvirke, omfatter: - p-piller eller kvindelig kønshormoner: hvis dit barn tager p-piller, som prævention, skal dit barn desuden anvende en anden præventionsform (f.eks. kondom).
English: Initiation of treatment should take into account the combinations of mutations which may negatively impact the virological response to Aptivus, coadministered with low dose ritonavir (see section 5.1).
Danish: Kombinationen af mutationer, der kan have en negativ påvirkning af det virologiske respons ved Aptivus plus lavdosis ritonavir behandlingen, bør vurderes før behandlingsstart (se pkt.
English: Co-administration of Aptivus, coadministered with low dose ritonavir, and rosuvastatin should be initiated with the lowest dose (5 mg/day) of rosuvastatin, titrated to treatment response, and accompanied with careful clinical monitoring for rosuvastatin associated symptoms as described in the label of rosuvastatin.
Danish: Samtidig behandling af rosuvastatin og Aptivus plus lavdosis ritonavir bør initieres med den lavest mulige rosuvastatindosis (5mg/dag), titreret til behandlings-respons, og efterfulgt af nøje monitorering af symptomer forbundet med rosuvastatin, jævnfør indlægssedlen for rosuvastatin.
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with flecainide, propafenone or metoprolol is contraindicated (see section 4.3)
Danish: Samtidig brug af Aptivus plus lavdosis ritonavir med flecainid, propafenon eller metoprolol er kontraindiceret (se pkt.
English: NAME OF THE MEDICINAL PRODUCT Aptivus 250 mg soft capsules tipranavir
Danish: LÆGEMIDLETS NAVN Aptivus 250 mg bløde kapsler tipranavir
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING BOTTLE/IMMEDIATE PACKAGING
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN INDRE EMBALLAGE BEHOLDER/INDRE EMBALLAGE
English: Carbamazepine should be used with caution in combination with Aptivus, co-administered with low dose ritonavir.
Danish: Der bør udvises forsigtighed ved brug af carbamazepin sammen med Aptivus og lavdosis ritonavir.
English: Your child must NOT stop taking Aptivus unless your child's doctor instructs to do so.
Danish: Behandlingen med Aptivus MÅ IKKE standses medmindre lægen siger, at dit barns behandling skal afbrydes.
English: Fever - Weight loss - Increased blood levels of the pancreas enzyme amylase - Increases in liver enzyme activity - Hepatitis with liver cell damage due to influence of a toxin
Danish: - nyrefunktionsfejl - influenza-lignende symptomer (generel sygdomsfølelse) - feber - vægttab - forhøjet indhold af bugspytkirtel-enzymet amylase i blodet - stigning i aktiviteten af leverenzymer - leverbetændelse med levercelleskade grundet udskillelse af et toksin (et giftstof)
English: According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended
Danish: Kombinationsbehandling med proteasehæmmere anbefales generelt ikke, jf. de gældende behandlingsguidelines.
English: In in vitro experiments, tipranavir was observed to inhibit human platelet aggregation at levels consistent with exposures observed in patients receiving Aptivus with ritonavir.
Danish: In vitro-studier viser, at tipranavir hæmmer trombocytaggregationen ved koncentrationer på niveau med de koncentrationer, der ses hos patienter i Aptivus med ritonavir behandling.
English: Other medicines with which Aptivus may interact include: - oral contraceptives/hormone replacement therapy (HRT): If you are taking the contraceptive pill to prevent pregnancy you should use an additional or different type of contraception (e.g. barrier contraception like condoms).
Danish: Anden medicin, som Aptivus kan påvirke, omfatter: - p-piller eller kvindelige kønshormoner: hvis du tager p-piller, som prævention, skal du desuden anvende en anden præventionsform (f.eks. kondom).
English: administered with low dose ritonavir, should be separated by at least 2 hours to avoid formulation incompatibility.
Danish: Administration af didanosin som enterotabletter og Aptivus bløde kapsler plus lavdosis ritonavir, bør foregå med mindst 2 timers mellemrum for at undgå uforligelighed mellem formuleringerne.
English: - bosentan (used to treat pulmonary artery hypertension) - halofantrine or lumefantrine (used to treat malaria) - tolterodine (used to treat overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence)) - boceprevir and telaprevir (used to treat hepatitis C) - cobicistat and products containing cobicistat (used to increase effectiveness of HIV medicines).
Danish: - tolterodin (anvendes til behandling af overaktiv blære (herunder symptomer som hyppig vandladning, vandladningstrang eller ufrivillig vandladning)) - boceprevir og telaprevir (til behandling af hepatitis C) - cobicistat og medicin, der indeholder cobicistat (anvendes til at øge virkningen af hiv-medicin).
English: The mechanism of action is thought to be induction of glucuronosyltransferase by tipranavir/r.
Danish: Virkningsmekanismen menes at være tipranavir/ritonavirs induktion af glucuronosyltransferase.
English: Atazanavir/ritonavir 300/100 mg QD (TPV/r 500/100 mg BID)
Danish: Atazanavir/ritonavir 300/100 mg x 1 (TPV/r 500/100 mg x 2)
English: Patients were required to have a baseline HIV-1 RNA concentration of at least 1500 copies/ml, were stratified by age (2 to < 6 years, 6 to < 12 years and 12 to 18 years) and randomized to receive one of two tipranavir with ritonavir dose regimens: 375 mg/m2/150 mg/m dose, compared to the 290 mg/m2/115 mg/m2 dose, plus background therapy of at least two nonprotease inhibitor antiretroviral medicinal products, optimized using baseline genotypic resistance testing.
Danish: Patienterne, med en påkrævet baseline hiv-1 RNA-koncentration på mindst 1500 kopier/ml, blev opdelt i aldersgrupperne (2 til< 6 år, 6 til < 12 år og 12 til 18 år), og blev randomiseret til en af de to dosisregimer med tipranavir med ritronavir: 375 mg/m2/150 mg/m2 dosis,
English: Midazolam Cmax ↔ Midazolam AUC ↑ 5.1 fold
Danish: Midazolam Cmax ↔ Midazolam AUC ↑ 5,1 gange
English: Based on theoretical considerations, co-administration of tipranavir with low dose ritonavir and alfuzosin results in increased alfuzosin concentrations and may result in hypotension.
Danish: Teoretisk forventes det, at samtidig administration af tipranavir plus lavdosis ritonavir og alfuzosin øger plasmakoncentrationen af alfuzosin, hvilket kan forårsage hypotension.
English: Rare: may affect up to 1 in 1,000 people - Liver failure (including fatal outcome) - Hepatitis - Fatty liver - Increased blood levels of bilirubin (a breakdown product of haemoglobin) - Dehydration (when the body does not have enough water) - Thinning of the face - Bleeding in the brain* (see above) - Increased blood levels of the pancreas enzyme lipase
Danish: Sjælden (kan forekomme hos op til 1 ud af 1000 patienter): - leversvigt (med dødeligt udfald) - leverbetændelse - fedtlever - forhøjet indhold af bilirubin i blodet (et nedbrydningsprodukt af hæmoglobin) - væskemangel (dehydrering) - vægttab i ansigtet - blødning i hjernen *(se ovenfor) - forhøjet indhold af bugspytkirtel-enzymet lipase i blodet.
English: This study was also conducted with Aptivus oral solution 500 mg with ritonavir 200 mg and showed the same CYP P450 and P-gp interactions as the Aptivus capsule 500 mg with ritonavir 200 mg. Based on the results from this study, Aptivus oral solution might be expected to have a similar interaction profile as the capsules.
Danish: De samme CYPP450 og P-gp interaktioner som for Aptivus 500 mg kapsler med 200 mg ritonavir sås i den arm af studiet, som blev udført med Aptivus oral opløsning/ritonavir 500mg/200mg.
English: Turn the bottle upside down and gently withdraw the required amount of Aptivus oral solution.
Danish: Vend bunden i vejret på flasken, og træk forsigtigt Aptivus-dosis ned i den orale sprøjte.
English: Tell your child's doctor or pharmacist if your child is taking, has recently taken or might take any other medicines, including medicines obtained without a prescription.
Danish: Fortæl det altid til lægen eller apotekspersonalet, hvis dit barn tager anden medicin eller har gjort det for nylig.
English: You must take Aptivus together with:
Danish: Aptivus skal tages sammen med følgende medicin:
English: 500 mg Tipranavir co-administered with low dose ritonavir (200 mg; twice daily) was associated with a 29-fold increase in the geometric mean morning steady-state trough plasma concentrations compared to tipranavir 500 mg twice daily without ritonavir.
Danish: 500 mg tipranavir plus lavdosis ritonavir (200 mg); to gange daglig resulterede i en 29 gange øgning af den geometriske middelværdi for den minimale morgen-steady state plasmakoncentration sammenlignet med tipranavir 500 mg to gange daglig uden ritonavir.
English: Generally, an increased frequency and higher severity of adverse reactions may result from overdose.
Danish: Ved en overdosering må der generelt forventes, at der forekommer en øget frekvens og en højere sværhedsgrad af bivirkninger.
English: Based on theoretical considerations, colchicine concentrations may increase upon co-administration with tipranavir and low dose ritonavir, due to tipranavir/ritonavir CYP3A and P-gp inhibition.
Danish: Teoretisk forventes det, at tipranavir plus lavdosis ritonavir øger koncentrationen af colchicin, pga. tipranavir/ritonavirs hæmning af CYP3A og P-gp.
English: Switching from Aptivus capsules to the oral solution Aptivus capsules are not interchangeable with the oral solution.
Danish: Behandlingsskift fra Aptivus kapsler til oral opløsning Aptivus kapsler kan ikke erstattes med den orale opløsning.
English: Antacids aluminium- and magnesiumbased antacid QD
Danish: Aluminium- og magnesiumbaserede antacida en gang daglig
English: Mono/diglycerides of caprylic/capric acid Propylene glycol
Danish: Mono-/diglycerider af capryl-/caprinsyre Propylenglycol
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with dihydroergotamine, ergonovine, ergotamine or methylergonovine is contraindicated due to potential serious and/or life threatening events (see section 4.3)
Danish: Samtidig brug af Aptivus plus lavdosis ritonavir med dihydroergotamin, ergonovin, ergotamin eller methylergonovin er kontraindiceret på grund af risiko for alvorlige og/eller livstruende bivirkninger (se pkt.
English: Therefore Aptivus, co-administered with low dose ritonavir, should be given with food.
Danish: Aptivus plus lavdosis ritonavir bør derfor gives med mad.
English: If your HIV is resistant to some HIV medicines, this means that the medicine will not work so well, or will not work at all.
Danish: Dette betyder, at medicinen ikke virker efter hensigten, eller slet ikke virker.
English: Taking Aptivus with etravirine is not recommended.
Danish: Det anbefales ikke at tage Aptivus sammen med etravirin.
English: Digoxin 0.25 mg QD po
Danish: Digoxin 0,25 mg x 1 p.o.
English: Skin and subcutaneous tissue disorders common rash uncommon pruritus, exanthem
Danish: Hud og subkutane væv Almindelig udslæt
English: PARTICULARS TO APPEAR ON THE OUTER FOLDING BOX/OUTER PACKAGING
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON/YDRE EMBALLAGE
English: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Efavirenz 600 mg QD No clinically significant interaction is observed.
Danish: Non-nukleosid reverse transkriptasehæmmere (NNRTI'er) Efavirenz 600 mg x 1
English: Your doctor will monitor your liver function by blood tests before and during Aptivus treatment.
Danish: Din læge vil tage blodprøver, før du starter på Aptivus-behandlingen og under behandlingen.
English: Recommendations concerning co-administration
Danish: Anbefalinger ved samtidig behandling
English: NAME OF THE MEDICINAL PRODUCT Aptivus 100 mg/ml oral solution tipranavir
Danish: LÆGEMIDLETS NAVN Aptivus 100 mg/ml oral opløsning tipranavir
English: See also Section 2, under “Oral contraceptives/hormone replacement therapy (HRT)”.
Danish: Se også afsnit 2, ”p-piller eller kvindelige kønshormoner”.
English: Clarithromycin Cmax ↔ Clarithromycin AUC ↑ 19% Clarithromycin Cmin ↑ 68%
Danish: Antibiotika Clarithromycin 500 mg x 2 Clarithromycin Cmax ↔ Clarithromycin AUC ↑ 19% Clarithromycin Cmin ↑ 68%
English: Stavudine
Danish: Stavudin
English: Loperamide 16 mg QD Loperamide Cmax ↓ 61% Loperamide AUC ↓ 51%
Danish: Loperamid Cmax ↓ 61% Loperamid AUC ↓ 51%
English: Triazolam No interaction study performed
Danish: Triazolam Der er ikke udført interaktionsstudier.
English: In use storage: 60 days, after first opening of the bottle.
Danish: Opbevaring efter anbrud: 60 dage.
English: There is a heterogeneous effect of telaprevir on ritonavir-boosted protease
Danish: Komparatorbehandlingen omfattede en ritonavir-boostet proteasehæmmer
English: NAME OF THE MEDICINAL PRODUCT Aptivus 100 mg/ml oral solution
Danish: LÆGEMIDLETS NAVN Aptivus 100 mg/ml oral opløsning
English: Hepatobiliary disorders uncommon hepatic enzyme increased (ALAT, ASAT), cytolytic hepatitis, liver function test abnormal (ALAT, ASAT), hepatitis toxic rare hepatic failure (including fatal outcome), hepatitis, hepatic steatosis, hyperbilirubinaemia
Danish: Lever og galdeveje Ikke almindelig forhøjede niveauer af leverenzymer (ALAT, ASAT), cytolytisk hepatitis, abnorm leverfunktionstest (ALAT, ASAT), toksisk hepatitis
English: Your child should not use Aptivusif they have never received antiretroviral therapy or have other antiretroviral options available.
Danish: Aptivus skal ikke ordineres til dit barn, hvis dit barn ikke tidligere har fået antiretroviral behandling, eller hvis anden antiretroviral behandling kan bruges.
English: You must take Aptivus in combination with low dose ritonavir and other antiretroviral medicines.
Danish: Aptivus skal altid tages sammen med lavdosis ritonavir og andre antiretrovirale midler.
English: Due to their metabolic profile and inherent risk of inducing torsades de pointes, administration of halofantrine and lumefantrine with Aptivus, co-administered with low dose ritonavir, is not recommended (see section 4.4).
Danish: Som følge af den metaboliske profil og iboende risiko for at fremkalde torsades de pointes kan indgivelse af halofantrin og lumefantrin med Aptivus plus lavdosisritonavir ikke anbefales (se pkt.
English: Rifabutin 150 mg QD Rifabutin Cmax ↑ 70% Rifabutin AUC ↑ 190%
Danish: Rifabutin Cmax ↑ 70% Rifabutin AUC ↑ 190% Rifabutin Cmin ↑ 114%
English: Alternative or additional contraceptive measures are to be used when oestrogen based oral contraceptives are co-administered with Aptivus co-administered with low dose ritonavir (see section 4.5).
Danish: Der skal anvendes alternativ eller yderligere antikonception, når der gives østrogenbaseret oral antikonception sammen med Aptivus, plus lavdosis ritonavir (se pkt.
English: Posology The recommended dose for children (age 2 to 12 years) is 375 mg/m2 Aptivus co-administered with
Danish: Dosering Den anbefalede dosis for børn (i alderen 2 til 12 år) er 375 mg/m2 Aptivus sammen med 150 mg/m ritonavir to gange dagligt.
English: Switching from Aptivus oral solution to the capsules Aptivus oral solution is not interchangeable with the capsules.
Danish: Behandlingsskift fra Aptivus oral opløsning til kapsler Aptivus oral opløsning kan ikke erstattes med kapslerne.
English: Co-administration of Aptivus, coadministered with low dose ritonavir, and pravastatin should be initiated with the lowest dose (10 mg/day) of pravastatin, titrated to treatment response, and accompanied with careful clinical monitoring for pravastatin associated symptoms as described in the label of pravastatin.
Danish: Samtidig behandling af pravastatin og Aptivus plus lavdosis ritonavir bør initieres med den lavest mulige pravastatindosis (10mg/dag), titreret til behandlingsrespons, og efterfulgt af nøje monitorering af symptomer forbundet med pravastatin, jævnfør indlægssedlen for pravastatin.
English: The combined use of Aptivus, coadministered with low dose ritonavir, with either omeprazole or esomeprazole is not recommended (see section 4.4).
Danish: Kombinationen af Aptivus plus lavdosis ritonavir, med enten omerprazol eller esomeprazol anbefales ikke (se pkt.
English: Aptivus is contraindicated in patients with moderate or severe (Child-Pugh Class B or C) hepatic insufficiency.
Danish: Aptivus er kontraindiceret til patienter med moderat eller svær leverinsufficiens (Child-Pugh B eller C).
English: Nervous system disorders common headache uncommon dizziness, neuropathy peripheral, somnolence rare intracranial haemorrhage*
Danish: Ikke almindelig svimmelhed, perifer neuropati, døsighed
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with pimozide, sertindole, quetiapine or lurasidone is contraindicated due to potential serious and/or life threatening events, including coma (see section
Danish: Samtidig brug af Aptivus plus lavdosis ritonavir med pimozid, sertindol, quetiapin eller lurasidon er kontraindiceret på grund af risiko for alvorlige og/eller livstruende bivirkninger, herunder koma (se pkt.
English: - omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole (proton pump inhibitors used to reduce the gastric acid production) - metronidazole (used to treat infections) - disulfiram (used to treat alcohol dependence) - buprenorphine/naloxone (medicines used to treat severe pain) - cyclosporin, tacrolimus, sirolimus (used to prevent organ rejection (to suppress the immune system)) - warfarin (used to treat and prevent thrombosis) - digoxin (used to treat heart arrhythmias and heart failure) - antifungal medications including fluconazole, itraconazole, ketoconazole or voriconazole
Danish: - buprenorphin/naloxon (anvendes til behandling af stærke smerter) - ciclosporin, tacrolimus, sirolimus (anvendes til at forhindre organafstødning (at undertrykke immunforsvaret)) - warfarin (anvendes til behandling og forebyggelse af trombose) - digoxin (anvendes til behandling af hjertearytmier og hjertesvigt) - svampedræbende medicin, herunder fluconazol, itraconazol, ketoconazol eller voriconazol
English: high liver function test results hepatitis B or C infection you are at increased risk of severe and potentially fatal liver damage while taking Aptivus.
Danish: Hvis du har: - forhøjede resultater af leverfunktionstest - hepatitis B eller C-infektion (leverbetændelse) er der en øget risiko for alvorlig eller evt. dødelig leverskade i den periode, hvor du tager Aptivus.
English: In patients with renal or hepatic impairment, coadministration of colchicine in patients on Aptivus/ritonavir is contraindicated (see section 4.3).
Danish: For patienter med nedsat nyre- eller leverfunktion er samtidig administration af colchicin og Aptivus/ritonavir kontraindiceret (se pkt.
English: Voriconazole No interaction study performed
Danish: Voriconazol Der er ikke udført interaktionsstudier.
English: Therefore, the co-administration of tipranavir, co-administered with low dose ritonavir, with protease inhibitors is not recommended.
Danish: Samtidig behandling med tipranavir plus lavdosis ritonavir med proteasehæmmere anbefales derfor ikke.
English: 40 mg BID > 60 kg 30 mg BID < 60 kg (TPV/r 750/100 mg BID)
Danish: 40 mg x 2 > 60 kg 30 mg x 2 < 60 kg (TPV/r 750/100 mg x 2)
English: Narcotic analgesics Methadone 5 mg QD Methadone Cmax ↓ 55% Methadone AUC ↓ 53% Methadone Cmin ↓ 50%
Danish: Metadon Cmax ↓ 55% Metadon AUC ↓ 53% Metadon Cmin ↓ 50%
English: Due to the marked hepatotoxicity of bosentan and the potential for increasing the liver toxicity associated with Aptivus,co-administered with low dose ritonavir, this combination is not recommended.
Danish: På grund af bosentans udtalte levertoksicitet og risiko for øget levertoksicitet ved samtidig administration af Aptivus plus lavdosis ritonavir frarådes kombinationen.
English: Gastrointestinal disorders very common diarrhoea, nausea common vomiting, flatulence, abdominal pain, abdominal distension, dyspepsia uncommon gastrooesophageal reflux disease, pancreatitis rare lipase increased
Danish: Almindelig opkastning, flatulens, abdominalsmerter, abdominal distension, dyspepsi
English: Due to their metabolic profile and inherent risk of inducing torsades de pointes, administration of halofantrine and lumefantrine with Aptivus co-administered with low dose ritonavir, is not recommended.
Danish: Som følge af den metaboliske profil og iboende risiko for at fremkalde torsades de pointes, kan indgivelse af halofantrin og lumefantrin sammen med Aptivus plus lavdosis ritonavir ikke anbefales.
English: Based on theoretical considerations, tipranavir or ritonavir concentrations might increase upon co-administration with itraconazole or ketoconazole.
Danish: Teoretisk forventes koncentrationerne af tipranavir eller ritonavir at øges ved samtidig behandling med itraconazol eller ketoconazol.
English: You should check with your child's doctor if they do wish to continue taking oral contraceptives or HRT.
Danish: Tal med dit barns læge om det, hvis det fortsat ønsker at tage p-piller eller kvindelige kønshormoner.
English: Due to reduction in the levels of the active metabolite norbuprenorphine, co-administration of Aptivus, coadministered with low dose ritonavir, and buprenorphine/naloxone may result in decreased clinical efficacy of buprenorphine.
Danish: Samtidig administration af Aptivus plus lavdosis ritonavir med buprenorphin/naloxon kan resultere i en nedsat klinisk effekt af buprenorphin, da niveauerne for den aktive metabolit, norbuprenorphin, reduceres.
English: Tipranavir, co-administered with low dose ritonavir, is expected to increase desipramine concentrations
Danish: Tipranavir plus lavdosis ritonavir forventes at øge desipraminkoncentrationerne.
English: Co-administration of etravirine and Aptivus/ritonavir is not recommended.
Danish: Samtidig administration af etravirin og Aptivus/ritonavir anbefales ikke.
English: If the co-administration is nevertheless considered necessary, a close monitoring of the safety of tipranavir and a monitoring of plasma concentrations of atazanavir are strongly encouraged (see section
Danish: Hvis kombinationen alligevel anses for nødvendig, anbefales det kraftigt både at monitorere sikkerheden af tipranavir og plasmakoncentrationerne for atazanavir (se pkt.