FrancophonIA/ELRC3.0 huggingface dataset:
English: The mean plasma terminal half-life (t1/2) for dapagliflozin was 12.9 hours following a single oral dose of dapagliflozin 10 mg to healthy subjects.
Croatian: Nakon jedne peroralne doze dapagliflozina od 10 mg u zdravih ispitanika srednji poluvijek (t1/2) dapagliflozina u plazmi iznosio je 12,9 sati.
English: EU/1/12/795/004 30 x 1 (unit dose) film-coated tablets EU/1/12/795/005 90 x 1 (unit dose) film-coated tablets
Croatian: EU/1/12/795/004 30 x 1 (jedinična doza) filmom obložena tableta EU/1/12/795/005 90 x 1 (jedinična doza) filmom obložena tableta
English: Results at Week 24 (LOCFa) in a placebo-controlled study of dapagliflozin in combination with insulin (alone or with oral glucose-lowering medicinal products)
Croatian: Tablica 6. Rezultati placebom kontroliranog ispitivanja dapagliflozina u kombinaciji s inzulinom (samostalno ili s peroralnim lijekovima za snižavanje razine glukoze) nakon 24 tjedna (LOCF
English: HbA1c (%) Baseline (mean) Change from baselinec
Croatian: HbA1c (%) Početna vrijednost (srednja) Promjena od početne vrijednosti c
English: adverse reactions of volume depletion, most commonly reported as hypotension, were reported in 1.7% and 0.8% of dapagliflozin-treated subjects and placebo-treated subjects, respectively (see section 4.4).
Croatian: U bolesnika u dobi od ≥ 65 godina nuspojave deplecije volumena, najčešće prijavljene u vidu hipotenzije, prijavljene su u 1,7% ispitanika koji su primali dapagliflozin i 0,8% ispitanika koji su primali placebo (vidjeti dio 4.4).
English: Approximately 70 g of glucose was excreted in the urine per day (corresponding to 280 kcal/day) at a dapagliflozin dose of 10 mg/day in subjects with type 2 diabetes mellitus for 12 weeks.
Croatian: koji su tijekom 12 tjedana primali dozu dapagliflozina od 10 mg na dan u mokraću je izlučeno otprilike 70 g glukoze na dan (što odgovara 280 kcal/dan).
English: See section 4.4 *Reported in ≥ 2% of subjects and ≥ 1 % more and at least 3 more subjects treated with dapagliflozin 10 mg compared to placebo.
Croatian: Vidjeti dio 4.4 Prijavljeno u ≥ 2% ispitanika liječenih dapagliflozinom u dozi od 10 mg i ≥ 1% češće te u najmanje 3 ispitanika više nego kod primjene placeba.
English: (95% CI) LOCF: Last observation (prior to rescue for rescued subjects) carried forward All randomised subjects who took at least one dose of double-blind study medication during the short-term double-blind period Least squares mean adjusted for baseline value p-value < 0.0001 versus placebo § Not evaluated for statistical significance as a result of the sequential testing procedure for secondary end points
Croatian: Svi randomizirani ispitanici koji su tijekom kratkoročnog dvostruko slijepog razdoblja uzeli barem jednu dozu ispitivanog lijeka u dvostruko slijepom ispitivanju Srednja vrijednost najmanjih kvadrata prilagođena za početnu vrijednost p-vrijednost < 0,0001 naspram placeba Nije procijenjena statistička značajnost zbog postupka sekvencijalnog testiranja za sekundarne mjere ishoda
English: AstraZeneca d.o.o.
Croatian: AstraZeneca S.p.A.
English: At Weeks 24 and 104, minor episodes of hypoglycaemia were reported, respectively, in 40.3% and 53.1% of subjects who received dapagliflozin 10 mg plus insulin and in 34.0% and 41.6% of the subjects who received placebo plus insulin.
Croatian: Kod ispitanika koji su primali dapagliflozin 10 mg u kombinaciji s inzulinom manje epizode hipoglikemije su prijavljene kod 40,3% ispitanika u 24. tjednu te kod 53,1% ispitanika u 104. tjednu, a kod ispitanika koji su primali placebo plus inzulin, manje epizode hipoglikemije su prijavljene kod 34,0% ispitanika u 24. tjednu te kod 41,6% ispitanika u 104. tjednu.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTERS PERFORATED UNIT DOSE 10 mg
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP PERFORIRANI BLISTERI DJELJIVI NA JEDINIČNE DOZE 10 mg
English: Musculoskeletal and connective tissue disorders
Croatian: Poremećaji mišićnokoštanog sustava i vezivnog tkiva bol u leđima
English: bColumns 1 and 2, HbA1c analyzed using LOCF (see footnote d); Columns 3 and 4, HbA1c analyzed using LRM (see footnote e) cLeast squares mean adjusted for baseline value dLOCF: Last observation (prior to rescue for rescued subjects) carried forward LRM: Longitudinal repeated measures analysis *p-value < 0.0001 versus placebo + oral glucose-lowering medicinal product(s)
Croatian: Stupci 1 i 2, HbA1c je analiziran koristeći LOCF (vidjeti opasku d); Stupci 3 i 4, HbA1c je analiziran koristeći LRM (vidjeti opasku e)
English: Combination therapy
Croatian: Kombinirano liječenje
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTERS PERFORATED UNIT DOSE 5 mg
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP PERFORIRANI BLISTERI DJELJIVI NA JEDINIČNE DOZE 5 mg
English: Results at Week 52 (LOCFa) in an active-controlled study comparing dapagliflozin to glipizide as add-on to metformin
Croatian: Rezultati ispitivanja kontroliranog aktivnim lijekom u kojem su se uspoređivali dapagliflozin i glipizid pridodani metforminu nakon 52 tjedna (LOCF
English: For the add-on to metformin study, HbA1c reductions were sustained through Week 102 (-0.78% and 0.02% adjusted mean change from baseline for 10 mg and placebo, respectively).
Croatian: U ispitivanju lijeka kao dodatka liječenju metforminom sniženja HbA1c održala su se do 102. tjedna (prilagođena srednja promjena u odnosu na početnu vrijednost za dozu dapagliflozina od 10 mg iznosila je -0,78%, a za placebo 0,02%).
English: These reactions were more common in patients with baseline eGFR ≥ 30 and < 60 mL/min/1.73m2 (18.5% dapagliflozin 10 mg vs 9.3%
Croatian: Te su reakcije bile češće u bolesnika čiji je početni eGFR iznosio ≥ 30 i < 60 ml/min/1,73 m
English: Na
Croatian: i
English: Dizziness
Croatian: Doziranje
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS CALENDAR BLISTERS NON-PERFORATED 10 mg
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP NEPERFORIRANI KALENDARSKI BLISTERI 10 mg
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS CALENDAR BLISTERS NON-PERFORATED 5 mg
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP NEPERFORIRANI KALENDARSKI BLISTERI 5 mg
English: (95% CI) Subjects (%) achieving: HbA1c < 7% (LOCF)d Adjusted for baseline Body weight (kg) (LOCF)d Baseline (mean) Change from baselinec Difference from placeboc (95% CI) 1glimepiride 4 mg/day; 2Metformin (immediate- or extended-release formulations) ≥1500 mg/day plus maximum tolerated dose, which must be at least half maximum dose, of a sulphonylurea for at least 8 weeks prior to enrollment.
Croatian: 2Metformin (s trenutnim ili produljenim oslobađanjem) ≥1500 mg/dan plus maksimalna podnošljiva doza sulfonilureje, koja mora iznositi barem pola maksimalne doze, najmanje 8 tjedana prije uključivanja u studiju.
English: Pruritus genital
Croatian: Tablični prikaz nuspojava
English: NAME OF THE MEDICINAL PRODUCT Forxiga 10 mg tablets dapagliflozin
Croatian: Forxiga 10 mg tablete dapagliflozin
English: (95% CI) LOCF: Last observation carried forward Randomised and treated subjects with baseline and at least 1 post-baseline efficacy measurement Least squares mean adjusted for baseline value dNon-inferior to glipizide + metformin p-value < 0.0001
Croatian: LOCF: Prijenos posljednjih zabilježenih vrijednosti (Last observation carried forward) Randomizirani i liječeni ispitanici kod kojih je izmjerena djelotvornost na početku liječenja i barem jednom nakon početka liječenja Srednja vrijednost najmanjih kvadrata prilagođena za početnu vrijednost Neinferiornost u odnosu na glipizid + metformin p-vrijednost < 0,0001
English: Vulvovaginitis, balanitis and related genital infections*,b,c Urinary tract infection*,b,d
Croatian: Infekcije i infestacije vulvovaginitis, balanitis i srodne genitalne infekcije
English: Very common Common*
Croatian: Vrlo često
English: 6.6 Special precautions for disposal No special requirements.
Croatian: 6.6 Posebne mjere za zbrinjavanje
English: Body weight (kg) Baseline (mean) Change from baselinec Difference from placeboc (95% CI) 1Metformin ≥ 1500 mg/day; 2sitagliptin 100 mg/day aLOCF: Last observation (prior to rescue for rescued subjects) carried forward bAll randomised subjects who took at least one dose of double-blind study medicinal product during the short-term double-blind period cLeast squares mean adjusted for baseline value *p-value < 0.0001 versus placebo + oral glucose-lowering medicinal product **p-value < 0.05 versus placebo + oral glucose-lowering medicinal product
Croatian: 2sitagliptin 100 mg/dan LOCF: Prijenos posljednjih zabilježenih vrijednosti (prije primjene terapije za nužnu regulaciju neregulirane glikemije u ispitanika kojima je ona primijenjena) (Last observation carried forward) Svi randomizirani ispitanici koji su tijekom kratkoročnog dvostruko slijepog razdoblja uzeli barem jednu dozu ispitivanog lijeka u dvostruko slijepom ispitivanju Srednja vrijednost najmanjih kvadrata prilagođena za početnu vrijednost p-vrijednost < 0,0001 u odnosu na placebo + peroralni lijek za snižavanje razine glukoze p-vrijednost < 0,05 u odnosu na placebo + peroralni lijek za snižavanje razine glukoze
English: Uncommon**
Croatian: **,b
English: Fungal infection**
Croatian: Srednja dnevna doza inzulina (IU)
English: Nocturia** Renal impairment**,b
Croatian: *,f nikturija oštećenje bubrega
English: NAME OF THE MEDICINAL PRODUCT Forxiga 5 mg tablets dapagliflozin
Croatian: Forxiga 5 mg tablete dapagliflozin
English: Increases in the amount of glucose excreted in the urine were observed in healthy subjects and in subjects with type 2 diabetes mellitus following the administration of dapagliflozin.
Croatian: U zdravih ispitanika i bolesnika sa šećernom bolešću tipa 2 je nakon primjene dapagliflozina primijećeno povećanje količine glukoze izlučene mokraćom.
English: aRandomized and treated patients with baseline and at least 1 post-baseline efficacy measurement.
Croatian: a Randomizirani i liječeni bolesnici kod kojih je mjerena djelotvornost pri početnoj vrijednosti te barem još jednom nakon početne vrijednosti.
English: Haematocrit increasedg
Croatian: Prijavljivanje nuspojava
English: Furthermore, two 12week, placebo-controlled studies were conducted in patients with inadequately controlled type 2 diabetes and hypertension.
Croatian: Osamdeset posto (80%) ispitanika imalo je indeks tjelesne mase (ITM)  27. Nadalje, dva 12-tjedna, placebom kontrolirana ispitivanja su provedena kod bolesnika s nedovoljno dobro reguliranom šećernom bolešću tipa 2 i hipertenzijom.
English: • The active substance is dapagliflozin.
Croatian: • Djelatna tvar je dapagliflozin.
English: NAME OF THE MEDICINAL PRODUCT Forxiga 10 mg film-coated tablets
Croatian: Forxiga 10 mg filmom obložene tablete
English: Add-on combination therapy
Croatian: Dodatak kombiniranom liječenju
English: EU/1/12/795/007 28 film-coated tablets
Croatian: EU/1/12/795/007 28 filmom obloženih tableta
English: EU/1/12/795/008 98 film-coated tablets
Croatian: EU/1/12/795/008 98 filmom obložene tablete
English: NAME OF THE MEDICINAL PRODUCT Forxiga 5 mg film-coated tablets
Croatian: Forxiga 5 mg filmom obložene tablete
English: EU/1/12/795/006 14 film-coated tablets
Croatian: EU/1/12/795/006 14 filmom obloženih tableta
English: EU/1/12/795/001 14 film-coated tablets
Croatian: EU/1/12/795/001 14 filmom obloženih tableta
English: EU/1/12/795/002 28 film-coated tablets
Croatian: EU/1/12/795/002 28 filmom obloženih tableta
English: EU/1/12/795/003 98 film-coated tablets
Croatian: EU/1/12/795/003 98 filmom obloženih tableta
English: LIST OF EXCIPIENTS Contains lactose.
Croatian: Sadrži laktozu.
English: AstraZeneca S.p.A. Tel: +39 02 9801 1
Croatian: Tel: +39 02 9801 1
English: ≥ 0.2% of subjects and ≥ 0.1% more and at least 3 more subjects treated with dapagliflozin 10 mg compared to placebo.
Croatian: Ocijenjeno od strane ispitivača kao moguće povezano, vjerojatno povezano ili povezano s ispitivanim liječenjem i prijavljeno u ≥ 0,2% ispitanika i ≥ 0,1% češće odnosno u najmanje 3 ispitanika više liječenih dapagliflozinom u dozi od 10 mg, nego u onih koji su primali placebo.
English: (95% CI) Mean daily insulin dose (IU)1
Croatian: Srednja dnevna doza inzulina (IU) Početna vrijednost (srednja)
English: NAME OF THE MEDICINAL PRODUCT Forxiga 10 mg film-coated tablets dapagliflozin
Croatian: Forxiga 10 mg filmom obložene tablete dapagliflozin
English: Dyslipidaemiah
Croatian: • omaglica
English: Nb
Croatian: b
English: Renal and urinary disorders
Croatian: Poremećaji bubrega i mokraćnog sustava dizurija poliurija
English: NAME OF THE MEDICINAL PRODUCT Forxiga 5 mg film-coated tablets dapagliflozin
Croatian: Forxiga 5 mg filmom obložene tablete dapagliflozin
English: Thirst**
Croatian: a)
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains dapagliflozin propanediol monohydrate equivalent to 10 mg dapagliflozin.
Croatian: Jedna tableta sadrži 10 mg dapagliflozina u obliku dapagliflozin propandiolhidrata.
English: Tel: +385 1 4628 000
Croatian: AstraZeneca d.o.o. Tel: +385 1 4628 000
English: Patients with renal impairment
Croatian: Bolesnici s oštećenjem bubrežne funkcije
English: This will help you remember to take it.
Croatian: Ovo će Vam pomoći da se sjetite uzeti ih.
English: Your body can also make too much sugar.
Croatian: Vaše tijelo također može stvarati previše šećera.
English: See section 3, “Taking this medicine”.
Croatian: Pogledajte dio 3, “Uzimanje ovog lijeka”.
English: What Invokana is and what it is used for
Croatian: Što se nalazi u ovoj uputi Što je Invokana i za što se koristi
English: • about what you can do to prevent dehydration
Croatian: • vezano uz to što možete poduzeti radi sprječavanja dehidracije
English: • Swallow the tablet whole with a half glass of water.
Croatian: • Progutajte tabletu cijelu s pola čaše vode.
English: • You can take your tablet with or without food.
Croatian: • Tabletu možete uzeti sa ili bez hrane.
English: • Do not take a double dose (two doses on the same day) to make up for a forgotten dose.
Croatian: • Nemojte uzeti dvostruku dozu (dvije doze u istom danu) kako biste nadoknadili zaboravljenu dozu.
English: Elderly (≥ 65 years old)
Croatian: Stariji (≥ 65 godina starosti)
English: Approximately 58% of patients were male.
Croatian: Otprilike 58% bolesnika bili su muškarci.
English: However, if it is nearly time for the next dose, skip the missed dose.
Croatian: Međutim, ako je blizu vremena za slijedeću dozu, preskočite propuštenu dozu.
English: This reduces the amount of sugar in your blood.
Croatian: To smanjuje količinu šećera u Vašoj krvi.
English: These reductions were sustained over the treatment period and near maximal after the first day of treatment.
Croatian: Ova smanjenja održala su se tijekom liječenja, a približile su se maksimalnim nakon prvog dana liječenja.
English: ATC code: A10BX11.
Croatian: ATK oznaka: A10BX11.
English: • Try to take it at the same time each day.
Croatian: • Nastojte tablete uzeti svaki dan u isto vrijeme.
English: It is best to take your tablet before the first meal of the day.
Croatian: Najbolje je uzeti tabletu prije prvog obroka u danu.
English: Children and adolescents Invokana is not recommended for children and adolescents under 18 years.
Croatian: Djeca i adolescenti Primjena lijeka Invokana se ne preporučuje u djece i adolescenata ispod 18 godina.
English: Your doctor will decide whether to increase your dose to 300 mg.
Croatian: Vaš će liječnik odlučiti o tome hoće li Vam povisiti dozu na 300 mg.
English: c Not applicable.
Croatian: c Nije primjenjivo.
English: In general, elevations were transient and did not require specific treatment.
Croatian: Općenito, povišenja su bila prolazna i nisu zahtijevala posebno liječenje.
English: Do not stop taking this medicine without talking to your doctor first.
Croatian: Nemojte prestati uzimati ovaj lijek bez da prethodno niste razgovarali sa svojim liječnikom.
English: Tablets should be swallowed whole.
Croatian: Tablete se moraju progutati cijele.
English: Other medicines and Invokana
Croatian: Drugi lijekovi i Invokana
English: If you take more of this medicine than you should, talk to a doctor straight away.
Croatian: Ako uzmete više ovog lijeka nego što biste trebali, odmah se obratite liječniku.
English: For further detail, it may be advisable to contact the specific manufacturer of the 1,5-AG assay.
Croatian: Za dodatne detalje bilo bi poželjno kontaktirati pojedinog proizvođača 1,5-AG testa.
English: Talk to your doctor about the best way to discontinue Invokana and control your blood sugar as soon as you know that you are pregnant.
Croatian: Razgovarajte sa svojim liječnikom o najboljem načinu za prekid uzimanja lijeka Invokana i o kontroli šećera u krvi čim saznate da ste trudni.
English: Balanitis or balanoposthitis**, h
Croatian: Balanitis ili balanopostitis**,h
English: • Your doctor will prescribe the strength that is right for you.
Croatian: • Liječnik će propisati odgovarajuću jačinu primjerenu Vama.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 15 November 2013
Croatian: Datum prvog odobrenja: 15. studenog 2013.
English: In particular, tell your doctor if you are taking any of the following medicines:
Croatian: Posebno, recite svom liječniku ako uzimate bilo koji od sljedećih lijekova:
English: Your doctor will tell you how to treat low blood sugar levels and what to do if you have any of the signs above.
Croatian: Liječnik će Vam reći kako ćete liječiti nisku razinu šećera u krvi i što treba učiniti ako Vam se pojavi bilo koji od gore navedenih znakova.
English: The doctor may decide to temporarily or permanently stop the treatment with Invokana.
Croatian: Vaš liječnik može odlučiti privremeno ili trajno prekinuti Vaše liječenje Invokanom.
English: • if you have ever had serious heart disease or if you have had a stroke
Croatian: • ako ste ikada imali ozbiljnu bolest srca ili ako ste ikada imali moždani udar
English: • if you have type 1 diabetes (your body does not produce any insulin).
Croatian: • ako imate šećernu bolest tipa 1 (Vaše tijelo uopće ne stvara inzulin).
English: Patients should be advised to report symptoms of volume depletion.
Croatian: Bolesnicima se mora savjetovati da prijave simptome deplecije volumena.
English: 16% of patients were Hispanic.
Croatian: 16% bolesnika bilo je hispano porijekla.
English: Dehydration*
Croatian: Dehidracija*
English: These differences are not considered to be clinically meaningful.
Croatian: Ove razlike se ne smatraju klinički značajanim.
English: Placebo-controlled studies
Croatian: Placebo-kontrolirana ispitivanja
English: • severe allergic reaction (may include swelling of the face, lips, mouth, tongue, or throat that may lead to difficulty breathing or swallowing).
Croatian: • teška alergijska reakcija (može uključivati oticanje lica, usnica, usta, jezika ili grla što može dovesti do otežanog disanja ili gutanja).
English: If a dose is missed, it should be taken as soon as the patient remembers; however, a double dose should not be taken on the same day.
Croatian: U slučaju propuštanja doze, bolesnik ju treba uzeti čim primjeti da je propuštena; međutim, ne smije se uzeti dvostruka doza u istom danu.
English: 4.5 Interaction with other medicinal products and other forms of interaction
Croatian: 4.5 Interakcije s drugim lijekovima i drugi oblici interakcija Farmakodinamičke interakcije
English: < 90 mL/min, no dose adjustment is needed.
Croatian: < 90 mL/min, nije potrebna prilagodba doze.
English: Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: The safety and efficacy of canagliflozin in children under 18 years of age have not yet been established.
Croatian: Sigurnost i djelotvornost kanagliflozina u djece u dobi ispod 18 godina nisu još ustanovljene.
English: Remember to take all medicines as directed by your doctor to achieve the best results for your health.
Croatian: Uvijek uzmite sve lijekove kako Vam je rekao liječnik, kako biste postigli nabolje rezultate za Vaše zdravlje.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, and genotoxicity.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponavljane doze i genotoksičnosti.
English: The effect of being homozygote (UGT1A9*3/*3, frequency < 0.1%) is probably more marked, but has not been investigated.
Croatian: Homozigotno svojstvo (UGT1A9*3/*3, učestalost < 0,1%) je vjerojatno više izraženo, ali nije bilo istraženo.
English: Also, some other medicines can affect the way this medicine works.
Croatian: Također, neki drugi lijekovi mogu imati utjecaj na djelovanje ovog lijeka.
English: Frequency categories are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Croatian: Katregorije učestalosti su definirane prema sljedećem sporazumu: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 to < 1/1000), vrlo rijetko (< 1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Possible signs of losing too much fluid from your body are listed at the top of section 4 “Possible side effects”.
Croatian: Mogući znakovi prevelikog gubitka tjelesne tekućine navedeni su na početku dijela 4 “Moguće nuspojave”.
English: This is because this medicine can affect the way some other medicines work.
Croatian: To je zbog toga jer ovaj lijek može imati utjecaj na djelovanje drugih lijekova.
English: Invokana should be taken orally once a day, preferably before the first meal of the day.
Croatian: Invokana se mora uzeti peroralno jedanput na dan, najbolje prije prvog obroka u danu.
English: • Your doctor may limit your dose to 100 mg if you have a kidney problem.
Croatian: • Liječnik Vam može ograničiti dozu na 100 mg, ako imate problema s bubrezima.
English: The racial distribution was 72% White, 16% Asian, 4% Black, and 8% other groups.
Croatian: Raspodjela po rasama bila je 72% bijelaca, 16% azijata, 4% crnaca i 8% ostalih skupina.
English: Invokana should not be used during pregnancy.
Croatian: Invokana se ne smije uzimati tijekom trudnoće.
English: 58% of patients had a body mass index (BMI) ≥ 30 kg/m2.
Croatian: 58% bolesnika imalo je indeks tjelesne težine (BMI) ≥ 30 kg/m2.
English: Maternal toxicity was limited to decreased body weight gain.
Croatian: Toksičnost koja se odnosi na majku bila je ograničena na smanjeno dobivanje na tjelesnoj težini.
English: Renal failure (mainly in the context of volume depletion)
Croatian: Zatajenje bubrega (većinom u kontekstu deplecije volumena)
English: Invokana should not be used to treat this condition.
Croatian: Invokana se ne smije uzimati za liječenje ovog stanja.
English: You may already be taking one or more of these to treat your type 2 diabetes.
Croatian: Možda već uzimate jedan ili više od tih lijekova za liječenje šećerne bolesti tipa
English: • if you are on medicines to lower your blood pressure (anti-hypertensives) or have ever had low blood pressure (hypotension).
Croatian: • ako uzimate lijekove za snižavanje krvnog tlaka (antihipertenzivni lijekovi) ili ste ikada imali nizak krvni tlak (hipotenziju).
English: In both cases, treatment with canagliflozin may be restarted once the patient's condition has stabilised.
Croatian: U oba slučaja, liječenje kanagliflozinom može se ponovno započeti nakon što se bolesnikovo stanje stabiliziralo.
English: • if you have severe liver problems
Croatian: • ako imate teške probleme s jetrom
English: Invokana should not be used for the treatment of diabetic ketoacidosis as it is not effective in this setting.
Croatian: Invokana se ne smije uzimati za liječenje dijabetičke ketoacidoze jer u tom slučaju nije učinkovita.
English: • loss of too much fluid from your body (dehydration).
Croatian: • gubitak prevelike količine tjelesne tekućine (dehidracija).