FrancophonIA/ELRC3.0 huggingface dataset:
English: There was no Y93H RAV present at baseline for genotype-3 infected patients treated for 12-weeks with sofosbuvir + daclatasvir + ribavirin, and thus SVR outcomes cannot
Slovenian: Pri bolnikih, okuženih z genotipom 3, ki so se 12 tednov zdravili s sofosbuvirjem + daklatasvirjem + ribavirinom, RAV Y93H v izhodišču ni bila prisotna, zato teh izidov SVR ni mogoče ovrednotiti.
English: NAME OF THE MEDICINAL PRODUCT Daklinza 60 mg film-coated tablets daclatasvir
Slovenian: IME ZDRAVILA Daklinza 60 mg filmsko obložene tablete
English: Italy
Slovenian: España
English: All 3 HCV/HIV co
Slovenian: Genotip 3 HCV (ALLY-3)
English: CARDIOVASCULAR AGENTS Antiarrhythmics
Slovenian: Srčne aritmije
English: Ribavirin Dosing Guideline
Slovenian: Etravirin Nevirapin
English: Coadministration of Daklinza with St. John's wort or other strong inducers of CYP3A4 is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba zdravila Daklinza s šentjanževko ali z drugimi močnimi induktorji CYP3A4 je kontraindicirana (glejte poglavje 4.3).
English: Cmax: 0.95 (0.89, 1.02) Cmin: 1.17 (1.10, 1.24)
Slovenian: Cmin: 0,89 (0,75; 1,06) Zvišanje pH vrednosti v želodcu.
English: One patient with HCV genotype 2 infection was missing both post
Slovenian: Pri enem bolniku, okuženem z genotipom 2 HCV, so manjkali podatki tako v 12. kot 24. tednu po zdravljenju.
English: The dose of Daklinza should be reduced to 30 mg once daily when coadministered with clarithromycin, telithromycin or other strong inhibitors of CYP3A4.
Slovenian: Pri sočasni uporabi klaritromicina, telitromicina ali drugih močnih zaviralcev CYP3A4 je treba odmerek zdravila Daklinza zmanjšati na 30 mg enkrat na dan.
English: Expected due to CYP3A4 inhibition by
Slovenian: Pričakovano zaradi zaviranja CYP3A4 z zdravili za zdravljenje bakterijskih
English: Musculoskeletal and connective tissue disorders arthralgia, myalgia arthralgia, myalgia
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva bolečina v sklepih, bolečina v mišicah bolečina v sklepih, bolečina v mišicah
English: If you take more Daklinza than you should
Slovenian: Če ste prenehali jemati zdravilo Daklinza
English: Discontinue peginterferon alfa and ribavirin (treatment with Daklinza is complete at week 24) Dose recommendation for concomitant medicines Strong inhibitors of cytochrome P450 enzyme 3A4 (CYP3A4)
Slovenian: Ukinite zdravljenje s peginterferonom alfa in z ribavirinom (zdravljenje z zdravilom Daklinza se konča v 24. tednu)
English: Each film-coated tablet contains 60 mg of daclatasvir (as dihydrochloride).
Slovenian: NAVEDBA ENE ALI VEČ ZDRAVILNIH UČINKOVIN Ena filmsko obložena tableta vsebuje 60 mg daklatasvirja (v obliki daklatasvirjevega diklorida).
English: dabigatran etexilate, used to to prevent blood clots ketoconazole, itraconazole, posaconazole or voriconazole, used to treat fungal infections verapamil, diltiazem, nifedipine or amlodipine, used to decrease blood pressure rosuvastatin, atorvastatin, fluvastatin, simvastatin, pitavastatin or pravastatin, used to lower blood cholesterol oral contraceptives
Slovenian: ketokonazol, itrakonazol, posakonazol ali vorikonazol, ki se uporabljajo za zdravljenje glivičnih okužb.
English: The dose of Daklinza should be increased to 90 mg once daily when coadministered with moderate inducers of CYP3A4.
Slovenian: Pri sočasni uporabi zmernih induktorjev CYP3A4 je treba odmerek zdravila Daklinza povečati na 90 mg enkrat na dan. Glejte poglavje 4.5.
English: Interaction not studied for this fixed Expected due to CYP3A4 inhibition by
Slovenian: ZDRAVILA ZA ZDRAVLJENJE BAKTERIJSKIH OKUŽB Pričakovano zaradi zaviranja CYP3A4 z zdravili za zdravljenje bakterijskih
English: There are no clinical data in patients with genotype 5 (see section 5.1).
Slovenian: Pri bolnikih, okuženih z genotipom 5, kliničnih podatkov ni
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 August 2014
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z
English: The dose of Daklinza should be reduced to 30 mg once daily when coadministered with boceprevir or other strong inhibitors of CYP3A4.
Slovenian: Pri sočasni uporabi boceprevirja ali drugih močnih zaviralcev CYP3A4 je treba odmerek zdravila Daklinza zmanjšati na 30 mg enkrat na dan.
English: Daklinza contains the active ingredient daclatasvir.
Slovenian: Kaj vsebuje zdravilo Daklinza Zdravilna učinkovina je daklatasvir.
English: No dose adjustment of Daklinza is required for patients aged ≥65 years (see section 5.2).
Slovenian: Pri bolnikih, starih 65 let ali starejših, odmerka zdravila Daklinza ni treba prilagajati (glejte
English: Cases of severe bradycardia and heart block have been observed when Daklinza is used in combination with sofosbuvir and concomitant amiodarone and/or other drugs that lower heart rate (see
Slovenian: Pri uporabi zdravila Daklinza v kombinaciji s sofosbuvirjem in sočasni uporabi amiodarona in/ali drugih zdravil, ki upočasnjujejo srčni utrip, so opazili primere hude bradikardije in srčnega bloka (glejte poglavji 4.4 in 4.5).
English: Use in diabetic patients
Slovenian: Ponovna uvedba zdravljenja z daklatasvirjem
English: Nucleotide analogue polymerase inhibitor
Slovenian: ZDRAVILA ZA ZDRAVLJENJE OKUŽB Z MIKOBAKTERIJAMI
English: Fusion inhibitor Enfuvirtide
Slovenian: ZDRAVILA ZA ZDRAVLJENJE GLIVIČNIH OKUŽB
English: Polyvinyl Chloride/poly-chloro-tri-fluoro-ethylene (PVC/PCTFE) clear blister/aluminum foil lidding.
Slovenian: Prozoren pretisni omot iz polivinilklorida/poliklorotrifluoroetilena (PVC/PCTFE), prekrit z Velikost pakiranja: 28 filmsko obloženih tablet v perforiranih enoodmernih pretisnih omotih.
English: Of these, only 27 completed the study.
Slovenian: Izmed teh jih je študijo dokončalo le 27.
English: 40 to 59
Slovenian: 40 do 59
English: Member State EU / EEA
Slovenian: Država članica ES / EGP
English: There were 48 patients enrolled and treated.
Slovenian: Vključenih in zdravljenih je bilo 48 bolnikov.
English: Show them your pack of tablets.
Slovenian: Pokažite jim vašo škatlico tablet.
English: 20 to 39
Slovenian: 20 do 39
English: 2100 Kopenhagen Ø Denmark
Slovenian: 2100 Kopenhagen Ø Danska
English: The duration of the active treatment period was only 8 weeks.
Slovenian: Zdravljenje z učinkovino je trajalo samo 8 tednov.
English: Section 4.6 was updated accordingly.
Slovenian: Poglavje 4.6 je bilo ustrezno posodobljeno.
English: It is normally spread by sexual contact.
Slovenian: Običajno se prenaša s spolnim stikom.
English: - If you have kidney problems (or have had them before).
Slovenian: - če imate težave z ledvicami (ali ste jih imeli kdaj prej).
English: It is especially important that you tell your doctor or pharmacist if you are taking any of the following medicines:
Slovenian: Posebno pomembno je, da poveste zdravniku ali farmacevtu, če jemljete katero od naslednjih zdravil:
English: - The daily dose and length of treatment will depend on the type of viral infection you have - see below.
Slovenian: - Dnevni odmerek in trajanje zdravljenja sta odvisna od vrste virusne okužbe, ki jo imate - glejte spodaj.
English: The design of Study 007 was considered to have some deficiencies.
Slovenian: Ocenjeno je bilo, da je imela zasnova študije 007 nekatere pomanjkljivosti.
English: 2 - 4, rue Lionel Terray 92500 Rueil-Malmaison France
Slovenian: 2 - 4, rue Lionel Terray 92500 Rueil-Malmaison Francija
English: 12th Km National Road No. 1 GR-144 51 Metamorphosis Greece
Slovenian: 12th Km National Road No. 1 GR-144 51 Metamorphosis Grčija
English: Ask your doctor for advice, if you think you may be allergic.
Slovenian: Posvetujte se z zdravnikom, če mislite, da bi lahko bili alergični.
English: This is important to prevent you passing the infection on to others.
Slovenian: To je pomembno, saj le tako lahko preprečite prenos okužbe na druge ljudi.
English: Elderly patients (≥ 65 years)
Slovenian: Starejši bolniki (stari 65 let ali več)
English: The CHMP noted that the Study 098 appeared acceptable with respect to design as well as results.
Slovenian: Odbor CHMP je omenil, da se zdi študija 098 glede na zasnovo in rezultate sprejemljiva.
English: Partly this difference may be due to differences in renal function between the two age groups.
Slovenian: Razlog za to razliko je lahko deloma v različni ledvični funkciji pri obeh starostnih skupinah.
English: • Raloxifen (used to prevent and treat osteoporosis).
Slovenian: • raloksifen (uporabljamo ga za preprečevanje in zdravljenje osteoporoze),
English: Your doctor will tell you how long you need to continue taking your tablets.
Slovenian: Zdravnik vam bo povedal, kako dolgo morate jemati te tablete.
English: The section was reviewed, in particular the regarding special populations, as the elderly.
Slovenian: Poglavje je bilo pregledano, zlasti z vidika posebnih skupin, kot so starejši bolniki.
English: However, the data were considered supportive.
Slovenian: Kljub temu je bilo ocenjeno, da podatki podpirajo indikacijo.
English: The duration of the study was considered too short to allow for a reliable assessment of the prophylactic efficacy of famciclovir.
Slovenian: Ocenjeno je bilo, da je trajanje študije prekratko, da bi bilo mogoče podati zanesljivo oceno profilaktične učinkovitosti famciklovirja.
English: If you forget to take a dose of Famvir, you should take it as soon as you remember.
Slovenian: Če ste pozabili vzeti odmerek zdravila Famvir, ga morate vzeti takoj, ko se spomnite.
English: The CHMP acknowledged that no comparative study with aciclovir was conducted.
Slovenian: CHMP je vzel na znanje, da ni bila opravljena nobena primerjalna raziskava z aciklovirjem.
English: The 10-day treatment duration was chosen to maximize the efficacy in this ‘at risk' population.
Slovenian: Za maksimaliziranje učinkovitosti pri tej rizični populaciji je bilo izbrano desetdnevno zdravljenje.
English: No dose adjustment based on gender is recommended.
Slovenian: Prilagajanje odmerjanja zaradi spola ni priporočeno.
English: In particular, the indications and their associated posology recommendations were harmonised.
Slovenian: Usklajene so bile zlasti indikacije in z njimi povezana priporočila za odmerjanje.
English: This section was updated to remove patient populations not studied as this should be mentioned in section 4.4.
Slovenian: To poglavje je bilo posodobljeno z namenom, da se izključijo skupine bolnikov, ki niso bile proučene in jih je treba omeniti v poglavju 4.4.
English: Famciclovir was considered equivalent to aciclovir if the upper limit of the 2-sided 95% confidence interval was less than 15%.
Slovenian: Famciklovir je štel za enakovrednega aciklovirju, če je bila zgornja meja dvostranskega 95-odstotnega intervala zaupanja manj kot 15 %.
English: In line with the information in section 5.3, this section was updated, in particular regarding male fertility.
Slovenian: To poglavje je bilo posodobljeno v skladu s podatki iz poglavja 5.3, in sicer zlasti kar zadeva moško plodnost.
English: Dizziness, somnolence.
Slovenian: omotičnost, somnolenca
English: In analogy with the above reports, it was hypothesized that probenecid may increase penciclovir AUC by approximately 50%.
Slovenian: Po analogiji z zgoraj navedenimi poročili je bila postavljena hipoteza, da lahko probenecid poveča izpostavljenost (AUC) penciklovirju za približno 50 %.
English: Section 4.4: Special warnings and precautions for use This section was updated to reflect the use in special populations which had previously been included in section 4.3.
Slovenian: Poglavje 4.4: Posebna opozorila in previdnostni ukrepi Poglavje je bilo posodobljeno tako, da podaja uporabo pri posebnih skupinah bolnikov, ki so bile prej vključene v poglavje 4.3.
English: It was however noted that although the secondary endpoints results did not indicate a difference, the study was not powered for proving non-inferiority.
Slovenian: Vendar je bilo poudarjeno, da čeprav rezultati sekundarnih pokazateljev niso kazali na razlike, zasnova študije ni omogočala dokazovanja neinferiornosti.
English: The minimum period of reassessment should include two recurrences.
Slovenian: Ponovno ocenjevanje mora trajati najmanj toliko, da pride do dveh ponovitev.
English: Recently two papers on human liver aldehyde oxidase inhibition in in vitro investigations were published (Obach 2004; Obach, et al 2004).
Slovenian: Nedavno sta bili objavljena dva članka o zaviranju aldehid oksidaze v človeških jetrih pri in vitro raziskavah (Obach, 2004, in Obach et al, 2004).
English: It is unknown whether famciclovir is excreted in human breast milk.
Slovenian: Ni znano, ali se famciklovir izloča v materino mleko.
English: - the Summary of Products Characteristic, labelling and package leaflet proposed by the Marketing Authorisation Holders have been assessed based on the documentation submitted and the scientific discussion within the Committee,
Slovenian: - povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo, ki so jih predlagali imetniki dovoljenja za promet, so bili ocenjeni na podlagi posredovane dokumentacije in znanstvene razprave v okviru Odbora;
English: Famvir is an antiviral medicine.
Slovenian: Famvir je protivirusno zdravilo.
English: Patients had to have lesions in the genital area.
Slovenian: Bolniki so morali imeti lezije v genitalnem predelu.
English: Uncommon side effects - Confusion - Severe skin reactions
Slovenian: Občasni neželeni učinki - zmedenost - hude kožne reakcije
English: Famciclovir should only be used during pregnancy when the potential benefits of treatment outweigh the potential risks.
Slovenian: Famciklovir je primerno uporabljati med nosečnostjo samo v primeru, da morebitne koristi zdravljenja odtehtajo možna tveganja.
English: Largo Umberto Boccioni 1 I-21040 Origgio Italy
Slovenian: Largo Umberto Boccioni 1 I-21040 Origgio Italija
English: For adverse reactions which have never been observed in these studies, the upper limit of the 95% confidence interval is not expected to be higher than 3/X (based on the “rule of three”), with X representing the total sample size (n=1,587).
Slovenian: Pri neželenih učinkih, ki jih v teh študijah niso opažali, ni mogoče pričakovati, da bi zgornja meja 95-odstotnega intervala zaupanja presegala 3/X (na podlagi "pravila trojke"), pri čemer X predstavlja velikost celotnega vzorca (n=1.587).
English: Novartis Farmacéutica S.A. Gran Via de les Corts Catalanes 764.E-08013 Barcelona Spain
Slovenian: Novartis Farmacéutica S.A. Gran Via de les Corts Catalanes 764.E-08013 Barcelona Španija
English: Although uncontrolled, study -195 provided some supportive evidence for the suppressive efficacy also in terms of other endpoints (virological/clinical recurrence).
Slovenian: Čeprav ni bila kontrolirana, je študija 195 prispevala določene dokaze o učinkovitosti z vidika supresije tudi glede na druge pokazatelje (virološka/klinična ponovitev).
English: Furthermore, do not take a double dose to make up for a forgotten dose.
Slovenian: Prav tako ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: No clinically significant interactions have been identified.
Slovenian: Ugotovljeno ni bilo nikakršno klinično pomembno medsebojno delovanje.
English: Do not drive or use machines if you have any of these symptoms while taking Famvir.
Slovenian: Ne vozite in ne upravljajte strojev, če imate med jemanjem zdravila Famvir katerega od teh simptomov.
English: This finding was reversible and has also been observed with other substances of this class.
Slovenian: Ta pojav je bil reverzibilen, opažali pa so ga tudi pri uporabi drugih učinkovin iz te skupine.
English: There is a limited amount of data (less than 300 pregnancy outcomes) from the use of famciclovir in pregnant women.
Slovenian: Obseg podatkov o uporabi famciklovirja pri nosečnicah je omejen (manj kot 300 izidov nosečnosti).
English: Hallucinations.
Slovenian: halucinacije
English: No unchanged famciclovir has been detected in urine.
Slovenian: Nespremenjenega famciklovirja v urinu niso našli.
English: A recent publication, by Money B et al, supported the inclusion of this warning, which was endorsed by the CHMP.
Slovenian: Nedavna publikacijo Moneya in drugih podpira vključitev tega opozorila, ki ga je potrdil CHMP.
English: While it appears paradoxical that the dose recommended to suppress recurrence of genital herpes is larger than that used to treat the active flare of a recurrence, the key endpoint was the time to clinically confirmed recurrence.
Slovenian: Čeprav se zdi protislovno, da je priporočeni odmerek za supresijo ponovitve genitalnega herpesa večji od odmerka, ki se uporablja pri zdravljenju aktivnega izbruha ponovitve, je bil ključni pokazatelj čas do klinično potrjene ponovitve.
English: • Do not use Famvir after the expiry date which is stated on the label after the expiry date.
Slovenian: • Zdravila Famvir ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini poleg oznake za rok uporabnosti.
English: [See Annex I - To be completed nationally] {Name and address} <{tel}> <{fax}> <{e-mail}>
Slovenian: [Glejte Dodatek I - Izpolni država članica] {Ime in naslov} <{tel.}> <{fax}> <{e-mail}>
English: If any of these applies to you, tell your doctor before you take Famvir.
Slovenian: Če karkoli od zgoraj navedenega velja za vas, povejte svojemu zdravniku, preden vzamete zdravilo Famvir.
English: WHAT FAMVIR IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO FAMVIR IN ZA KAJ GA UPORABLJAMO
English: However, the selection of placebo controls for both studies was questionable.
Slovenian: Vendar je bil izbor placeba kot primerjave pri obeh študijah vprašljiv.
English: Pharmacotherapeutic group: Nucleosides and nucleotides excluding reverse transcriptase inhibitors, ATC code: JO5AB09
Slovenian: Farmakoterapevtska skupina: nukleozidi in nukleotidi (razen zaviralcev reverzne transkriptaze), oznaka ATC: J05AB09
English: Dose for genital herpes The dose depends on the state of your immune system, and the stage of your infection.
Slovenian: Odmerek za genitalni herpes Višina odmerka je odvisna od stanja imunskega sistema in od stopnje okužbe.
English: The CHMP noted the recommended doses for the different posologies as indicated above.
Slovenian: CHMP je potrdil priporočene odmerke za različne režime odmerjanja, kakor je navedeno zgoraj.
English: Patients who continue to have significant disease may restart suppressive therapy.
Slovenian: Bolniki, pri katerih se bolezen še vedno pojavlja v pomembni meri, lahko ponovno začnejo s supresivnim zdravljenjem.
English: General toxicity Studies on safety pharmacology and repeated dose toxicity reveal no special hazard for humans.
Slovenian: Podatki študij farmakološke varnosti in toksičnosti pri ponavljajočih se odmerkih ne kažejo posebnega tveganja za človeka.
English: Elderly patients (≥ 65 years) Dose modification is not required unless renal function is impaired.
Slovenian: Starejši bolniki (stari 65 let ali več) Spremembe odmerkov niso potrebne, če bolnik nima okvare ledvic.
English: Blood and lymphatic system disorders Rare:
Slovenian: Bolezni krvi in limfatičnega sistema redki:
English: Additionally, a warning was revised to state that even though the frequency of viral shedding was reduced with the use of an antiviral, the risk of transmission is still theoretically possible so patients should be advised to avoid intercourse.
Slovenian: Poleg tega je bilo opozorilo spremenjeno tako, da navaja, da čeprav se pogostost izločanja virusa z uporabo protivirusnega zdravila zmanjša, teoretično še obstaja tveganje za prenos, zato je treba bolnikom svetovati, naj se vzdržijo spolnih odnosov.
English: Animal studies did not indicate any negative effect on female fertility.
Slovenian: Rezultati študij na živalih niso kazali na škodljiv vpliv na plodnost pri samicah.
English: Section 4.5: Interaction with other medicinal products and other forms of interaction
Slovenian: Poglavje 4.5: Medsebojno delovanje z drugimi zdravili in druge oblike interakcij
English: Evidence from preclinical studies has shown no potential for induction of cytochrome P450 enzymes and inhibition of CYP3A4.
Slovenian: Podatki iz predkliničnih študij ne kažejo potenciala za induciranje encimov citokroma P450 ali za zaviranje CYP3A4.
English: In the event of an overdose supportive and symptomatic therapy should be given as appropriate.
Slovenian: V primeru prevelikega odmerjanja je treba poskrbeti za ustrezno podporno in simptomatsko zdravljenje.
English: - If you have or have had kidney problems, your doctor may decide to give you a lower dose of Famvir.
Slovenian: - Če imate težave z ledvicami ali ste jih imeli kdaj prej, vam bo zdravnik morda predpisal nižji odmerek zdravila Famvir.
English: The CHMP recommended also the revocation of the 750 mg film coated tablets for Famvir and associated names.
Slovenian: Odbor CHMP je predlagal tudi razveljavitev 750-miligramskih filmsko obloženih tablet za zdravilo Famvir in z njim povezana imena.
English: This is because you could pass the herpes infection to your partner.
Slovenian: Pri spolnih stikih bi namreč lahko prenesli herpes na svojega partnerja.
English: Over the 4 months of Study 195, 90% of HIV-infected patients remained free from clinically diagnosed recurrences.
Slovenian: Po štirih mesecih trajanja raziskave 195 pri 90 % bolnikov, okuženih s HIV, ni prišlo do klinično diagnosticiranih ponovitev.
English: Do not take Famvir - If you are allergic (hypersensitive) to famciclovir, to any of the other ingredients of Famvir listed in section 6, or to penciclovir (the active metabolite of famciclovir and an ingredient of some other medicines).
Slovenian: Ne jemljite zdravila Famvir - če ste alergični (preobčutljivi) na famciklovir, na katerokoli sestavino zdravila Famvir, ki je navedena v poglavju 6, ali na penciklovir (ki je aktivni presnovek famciklovirja in sestavina nekaterih drugih zdravil).
English: The statement that the testicular findings were largely reversible is supported by observations made in the chronic dose toxicity studies in which the testicular findings were largely reversible after a 12-week duration of recovery and partially reversed after shorter recovery periods.
Slovenian: Izjavo, da so najdbe na testisih v veliki meri reverzibilne, podpirajo ugotovitve iz študij kronične toksičnosti, ki so pokazale na veliko stopnjo reverzibilnosti najdb na testisih po 12-tedenskem okrevanju in delno reverzibilnost po krajših obdobjih okrevanja.
English: Taking Famvir with food and drink You can take Famvir with or without food.
Slovenian: Jemanje zdravil Famvir skupaj s hrano in pijačo Zdravilo Famvir lahko jemljete s hrano ali brez nje.
English: Section 4.8: Undesirable effects
Slovenian: Poglavje 4.8: Neželeni učinki
English: Section 4.6: Pregnancy and lactation
Slovenian: Poglavje 4.6: Nosečnost in dojenje
English: If patients experience severe dizziness, somnolence, confusion or other central nervous system disturbances, a dose reduction of famciclovir to 250 mg three times daily may be considered.
Slovenian: Če pride do hude omotičnosti, somnolence, zmedenosti ali drugih motenj v delovanju centralnega živčevja, je mogoče razmisliti o znižanju odmerka famciklovirja na 250 mg trikrat na dan.
English: A total of 14 patients were withdrawn in Period 1 and 7 patients were withdrawn in Period 2.
Slovenian: V prvem obdobju je bilo iz raziskave izključenih 14, v drugem obdobju pa 7 bolnikov.
English: However, it cannot be excluded that short-term treatment with high dosages (e.g., 500mg tid) may affect male fertility in humans.
Slovenian: Kljub temu ni mogoče izključiti, da lahko kratkoročno zdravljenje z velikimi odmerki (npr. 500 mg trikrat dnevno) vpliva na moško plodnost.
English: Treatment should be initiated as soon as possible after a diagnosis of herpes zoster.
Slovenian: Z zdravljenjem je treba začeti čimprej po postavitvi diagnoze herpesa zostra.
English: Therefore, a placebo arm was not included, which makes comments on the absolute effectiveness of antiviral agents in preventing ocular complications in this study tenuous.
Slovenian: Krak s placebom zato ni bil vključen, zaradi česar bi bile pripombe o absolutni učinkovitosti protivirusnih učinkovin pri preprečevanju očesnih zapletov v tej študiji dvomljive.