FrancophonIA/ELRC3.0 huggingface dataset:
English: The metabolism of fulvestrant has not been fully evaluated, but involves combinations of a number of possible biotransformation pathways analogous to those of endogenous steroids.
Croatian: Metabolizam fulvestranta nije u potpunosti razjašnjen, ali uključuje kombinacije većeg broja mogućih putova biotransformacije, analognih onima endogenih steroida.
English: ADR was not observed in FALCON.
Croatian: Nuspojava nije opažena u ispitivanju FALCON.
English: Frequency groupings are defined according to the following convention: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100).
Croatian: Za učestalost pojavljivanja korištena je sljedeća kategorizacija: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100).
English: This is calculated as 3/560 (where 560 is the number of patients in the major clinical studies), which equates to a frequency category of ‘uncommon'.
Croatian: Tako izračunata vrijednost iznosi 3/560 (gdje je 560 broj bolesnika u glavnim kliničkim ispitivanjima), što odgovara kategoriji učestalosti „manje često“.
English: After temperature excursions, the product should be returned immediately to the recommended storage conditions (store and transport in a refrigerator 2°C - 8°C).
Croatian: Nakon temperaturnog odstupanja, lijek treba odmah vratiti u preporučene uvjete čuvanja (čuvati i prevoziti na hladnom, na temperaturi od 2°C - 8°C).
English: If you have any questions about palbociclib, please ask your doctor.
Croatian: Ako imate bilo kakvih pitanja o palbociklibu, obratite se svom liječniku.
English: The median time to death was 27.4 months for patients treated with Faslodex and 27.6 months for patients treated with anastrozole.
Croatian: Medijan vremena do smrti iznosio je 27,4 mjeseca za bolesnice liječene lijekom Faslodex, a 27,6 mjeseci za bolesnice liječene anastrozolom.
English: K-M median in months; hazard ratio
Croatian: K-M medijan u mjesecima; omjer hazarda
English: More than half (62%) had an ECOG PS of 0, 60% had visceral metastases, and 60% had received more than 1 prior hormonal regimen for their primary diagnosis.
Croatian: Više od polovice bolesnica (62%) imalo je funkcionalni ECOG status 0, 60% njih imalo je visceralne metastaze, dok je njih 60% prethodno primilo više od 1 režima hormonske terapije za primarnu dijagnozu.
English: TTR*, Median [months (range)]
Croatian: TTR*, medijan [mjeseci (raspon)]
English: Nominal p-value with no adjustments made for multiplicity between the initial overall survival analyses at 50% maturity and the updated survival analyses at 75% maturity.
Croatian: Nominalna p-vrijednost bez korekcije za multiplicitet između inicijalnih analiza ukupnog preživljenja pri 50%-tnoj zrelosti podataka i ažuriranih analiza preživljenja pri 75%-tnoj zrelosti podataka.
English: Fulvestrant is subject to extensive and rapid distribution.
Croatian: Fulvestrant se opsežno i brzo raspodjeljuje.
English: In toxicity studies with multiple intramuscular doses of fulvestrant in rats and dogs, the antiestrogenic activity of fulvestrant was responsible for most of the effects seen, particularly in the female reproductive system, but also in other organs sensitive to hormones in both sexes.
Croatian: U istraživanjima toksičnosti višekratnih intramuskularnih doza fulvestranta u štakora i pasa, antiestrogeno djelovanje fulvestranta bilo je odgovorno za većinu opaženih učinaka, osobito u reproduktivnom sustavu ženki, ali i u drugim organima osjetljivima na hormone u oba spola.
English: The pre-filled syringe presentation consists of:
Croatian: Pakiranje s napunjenom štrcaljkom sastoji se od:
English: The efficacy results of the FALCON study are presented in Table 4 and Figure 1.
Croatian: Rezultati za djelotvornost u ispitivanju FALCON prikazani su u Tablici 4 i na Slici 1.
English: A more mature update of efficacy data is reported in Table 5.
Croatian: Zreliji podaci o djelotvornosti navedeni su u Tablici 5.
English: The major route of excretion is via the faeces, with less than 1% being excreted in the urine.
Croatian: Glavni put izlučivanja je fecesom, a manje od 1% izluči se mokraćom.
English: Tell your doctor, pharmacist, or nurse if you notice any of the following side effects:
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako primijetite neku od sljedećih nuspojava:
English: Administer the injection according to the local guidelines for performing large volume intramuscular injections.
Croatian: Primijenite injekciju prema lokalnim smjernicama za primjenu intramuskularnih injekcija velikog volumena.
English: To maintain sterility do not touch the syringe tip (B) (see Figure 2).
Croatian: Kako bi se održala sterilnost, ne dirajte vrh štrcaljke (B) (vidjeti Sliku 2).
English: The large apparent volume of distribution at steady state (Vdss) of approximately 3 to 5 l/kg suggests that distribution is largely extravascular.
Croatian: Velik prividni volumen distribucije u stanju dinamičke ravnoteže (Vdss) od oko 3 do 5 l/kg ukazuje da se uglavnom raspodjeljuje ekstravaskularno.
English: Other medicines and Faslodex
Croatian: Drugi lijekovi i Faslodex
English: • Abnormal levels of liver enzymes (in blood tests)*
Croatian: • abnormalna razina jetrenih enzima (u krvnim pretragama)*
English: PFS:Progression-free survival; ORR:Objective response rate; OR:Objective response; CBR:Clinical benefit rate; CB:Clinical benefit; OS:Overall survival; K-M:Kaplan-Meier; CI:Confidence interval; AI:Aromatase inhibitor; AE:Antiestrogen.
Croatian: PFS: preživljenje bez progresije bolesti; ORR: objektivna stopa odgovora; OR: objektivni odgovor; CBR: stopa kliničke koristi; CB: klinička dobit; OS: ukupno preživljenje; K-M: Kaplan-Meier; CI: interval pouzdanosti; AI: inhibitor aromataze; AE: antiestrogen.
English: Grade ≥ 3 n (%)
Croatian: ≥ 3. stupanj n (%)
English: Patients continued to receive assigned treatment until objective disease progression, symptomatic deterioration, unacceptable toxicity, death, or withdrawal of consent, whichever occurred first.
Croatian: Bolesnice su nastavile primati dodijeljeno im liječenje do objektivne progresije bolesti, pogoršanja simptoma, neprihvatljive toksičnosti, smrti ili povlačenja pristanka, ovisno o tome što je nastupilo prvo.
English: Faslodex is contraindicated in pregnancy (see section 4.3).
Croatian: Faslodex je kontraindiciran tijekom trudnoće (vidjeti dio 4.3).
English: Keep the pre-filled syringe in the original package, in order to protect from light.
Croatian: Napunjenu štrcaljku čuvati u originalnom pakiranju radi zaštite od svjetlosti.
English: • Inflammation of the liver (hepatitis)
Croatian: • upala jetre (hepatitis)
English: After intramuscular administration, the exposure is approximately dose-proportional in the dose range 50 to 500 mg.
Croatian: Nakon intramuskularne primjene izloženost je približno proporcionalna dozi u rasponu doza od 50 do 500 mg.
English: What Faslodex is and what it is used for
Croatian: Što je Faslodex i za što se koristi
English: Overall, Faslodex at the 250 mg monthly dose was at least as effective as anastrozole in terms of progression-free survival, objective response, and time to death.
Croatian: Sveukupno je Faslodex u mjesečnoj dozi od 250 mg bio barem jednako učinkovit kao anastrozol u smislu preživljenja bez progresije bolesti, objektivnog odgovora i vremena do smrti.
English: • Increase of bilirubin (bile pigment produced by the liver)
Croatian: • povišene vrijednosti bilirubina (žučnog pigmenta koji proizvodi jetra)
English: Patients enrolled in this study had a median age of 63 years (range 36-90).
Croatian: Bolesnice uključene u ovo ispitivanje imale su medijan dobi od 63 godine (raspon: 36 - 90).
English: Fulvestrant blocks the trophic actions of estrogens without any partial agonist (estrogen-like) activity.
Croatian: Fulvestrant blokira trofičko djelovanje estrogena, a da sam nema nikakvog djelomično agonističkog (estrogenu sličnog) djelovanja.
English: A total of 17.1% of patients received a prior chemotherapy regimen for advanced disease; 84.2% of patients had measurable disease.
Croatian: Ukupno je 17,1% bolesnica prethodno primilo kemoterapijski protokol za uznapredovalu bolest; 84,2% bolesnica imalo je mjerljivu bolest.
English: Progression-Free Survival Probability (%)
Croatian: Vjerojatnost preživljenja bez progresije bolesti (%)
English: The mechanism of action is associated with downregulation of estrogen receptor protein levels.
Croatian: Mehanizam djelovanja povezan je sa snižavanjem razine proteina estrogenskih receptora.
English: Faslodex contains the active substance fulvestrant, which belongs to the group of estrogen blockers.
Croatian: Faslodex sadržava djelatnu tvar fulvestrant, koja pripada skupini blokatora estrogena.
English: Faslodex and other formulations of fulvestrant were well tolerated in animal species used in multiple dose studies.
Croatian: Faslodex i druge oblike fulvestranta dobro su podnosile životinjske vrste korištene u istraživanjima višekratnih doza.
English: All Grades n (%)
Croatian: Svi stupnjevi n (%)
English: • Check that the needle is locked to the Luer connector before moving out of the vertical plane.
Croatian: • Provjerite da je igla zaključana na Luer spojnicu prije nego je pomaknete iz vertikalnog položaja.
English: This may be harmful for those suffering from alcoholism and should be taken into account in high risk groups such as patients with liver disease and epilepsy.
Croatian: To može biti štetno za osobe koje boluju od alkoholizma, i treba se uzeti u obzir kod primjene u bolesnika s visokim rizikom, kao što su bolesnici sa jetrenim bolestima i epilepsijom.
English: SE-151 85 Södertälje Sweden
Croatian: SE-151 85 Södertälje Švedska
English: What Faslodex is and what it is used for What you need to know before you use Faslodex How to use Faslodex
Croatian: Što je Faslodex i za što se koristi Što morate znati prije nego počnete primjenjivati Faslodex Kako primjenjivati Faslodex
English: • After injection, immediately apply a single-finger stroke to the activation assisted lever arm to activate the shielding mechanism (see Figure 5).
Croatian: • Nakon injekcije, odmah jednim prstom pogurnite ručicu aktivacijske poluge kako biste aktivirali mehanizam za zaštitu igle (vidjeti Sliku 5).
English: The median duration of fulvestrant 500 mg treatment across the pooled dataset (including the studies mentioned above plus FALCON) was 6.5 months.
Croatian: Medijan trajanja liječenja fulvestrantnom u dozi od 500 mg u objedinjenom skupu podataka (koji uključuju podatke iz prethodno navedenih ispitivanja i ispitivanja FALCON), iznosio je 6,5 mjeseci.
English: Includes: arthralgia, and less frequently musculoskeletal pain, myalgia and pain in extremity.
Croatian: Uključuje: artralgiju, a manje često i bol u mišićima i kostima, mialgiju te bol u ekstremitetima.
English: Excipients with known effect (per 5 ml) Ethanol (96%, 500 mg) Benzyl alcohol (500 mg) Benzyl benzoate (750 mg)
Croatian: Pomoćne tvari s poznatim učinkom (u 5 ml) Etanol (96%, 500 mg) Benzilni alkohol (500 mg) Benzilbenzoat (750 mg)
English: Febrile neutropenia has been reported in 0.9% patients receiving fulvestrant in combination with palbociclib.
Croatian: Febrilna neutropenija prijavljena je u 0,9% bolesnica koje su primale fulvestrant u kombinaciji s palbociklibom.
English: There was also a significant decrease in progesterone receptor expression consistent with a lack of intrinsic estrogen agonist effects.
Croatian: Zabilježeno je i značajno smanjenje ekspresije progesteronskih receptora, što je u skladu s izostankom intrinzičnih učinaka agonista estrogena.
English: AstraZeneca UK Limited Silk Road Business Park, Macclesfield, SK10 2NA United Kingdom
Croatian: AstraZeneca UK Limited Silk Road Business Park, Macclesfield, SK10 2NA Ujedinjeno Kraljevstvo
English: The efficacy and safety of Faslodex (either as monotherapy or in combination with palbociclib) have not been studied in patients with critical visceral disease.
Croatian: Djelotvornost i sigurnost lijeka Faslodex (bilo u monoterapiji ili u kombinaciji s palbociklibom) nisu se ispitivale u bolesnica s kritičnom visceralnom bolešću.
English: Faslodex is indicated:
Croatian: Faslodex je indiciran:
English: No data are available regarding endometrial morphology.
Croatian: Nisu dostupni podaci o morfologiji endometrija.
English: Additional efficacy measures (OR and TTR) assessed in the sub-groups of patients with or without visceral disease are displayed in Table 6.
Croatian: Dodatne mjere ishoda za djelotvornost (OR i TTR) koje su se ocjenjivale u podskupinama bolesnica s visceralnom bolešću ili bez nje prikazane su u Tablici 6.
English: Therefore these findings are not considered to be relevant to the use of fulvestrant in postmenopausal women with advanced breast cancer.
Croatian: Stoga se ovi nalazi ne smatraju značajnima za primjenu fulvestranta u žena u postmenopauzi s uznapredovalim rakom dojke.
English: All patients had received prior systemic therapy and most patients in each treatment arm had received a previous chemotherapy regimen for their primary diagnosis.
Croatian: Sve bolesnice prethodno su primale sistemsku terapiju, a većina bolesnica u svakoj liječenoj skupini prethodno je primila kemoterapijski režim za primarnu dijagnozu.
English: Although the data collected were limited, the steady-state trough concentrations of fulvestrant in children appear to be consistent with those in adults.
Croatian: Iako su prikupljeni podaci bili ograničeni, čini se da su najniže koncentracije fulvestranta u stanju dinamičke ravnoteže u djece u skladu s onima u odraslih.
English: • Injection site reactions, such as pain and/or inflammation
Croatian: • reakcije na mjestu injekcije, kao što je bol i/ili upala
English: Fulvestrant is excreted in milk in lactating rats.
Croatian: Fulvestrant se izlučuje u mlijeko štakorica u laktaciji.
English: Key secondary efficacy endpoints included overall survival (OS) and objective response rate (ORR).
Croatian: Ključne sekundarne mjere ishoda za djelotvornost uključivale su ukupno preživljenje (OS) i stopu objektivnog odgovora (ORR).
English: If you can become pregnant, you should use effective contraception while you are being treated with Faslodex and for 2 years after your last dose.
Croatian: Ako biste mogli zatrudnjeti, morate koristiti učinkovitu kontracepciju dok se liječite lijekom Faslodex i tijekom 2 godine nakon Vaše posljednje doze.
English: The results in the AI subgroup are inconclusive.
Croatian: Rezultati u AI podskupini ne omogućuju konačan zaključak.
English: In a population pharmacokinetic analysis of data from Phase 3 studies, no difference in fulvestrant's pharmacokinetic profile was detected with regard to age (range 33 to 89 years), weight (40-127 kg) or race.
Croatian: U analizi podataka populacijske farmakokinetike iz ispitivanja faze 3, nisu otkrivene razlike u farmakokinetičkom profilu fulvestranta s obzirom na dob (raspon 33 do 89 godina), tjelesnu težinu (40-127 kg) ili rasu.
English: • Weakness, tiredness*
Croatian: • slabost, umor*
English: Your doctor or nurse will give you Faslodex as a slow intramuscular injection, one into each of your buttocks.
Croatian: Vaš liječnik ili medicinska sestra će Vam dati Faslodex sporom injekcijom u mišić, po jednu injekciju u svaki mišić stražnjice.
English: For full instructions on the administration of Faslodex and the use of the safety needle see enclosed, Instructions for administration.
Croatian: Za cjelovite upute o načinu primjene lijeka Faslodex i uporabi sigurnosne igle vidjeti priložene Upute za primjenu.
English: A reduction in the risk of disease progression or death in the Faslodex plus palbociclib arm was observed in all individual patient subgroups defined by stratification factors and baseline characteristics.
Croatian: Smanjenje rizika od progresije bolesti ili smrti u skupini koja je primala Faslodex plus palbociklib primijećeno je u svim pojedinačnim podskupinama bolesnica definiranima prema stratifikacijskim faktorima i početnim značajkama.
English: Two syringes must be administered to receive the 500 mg recommended monthly dose.
Croatian: Moraju se primijeniti dvije štrcaljke kako bi se dobila preporučena mjesečna doza od 500 mg.
English: The terminal half-life (t1/2) after intramuscular administration is governed by the absorption rate and was estimated to be 50 days.
Croatian: Poluvijek (t1/2) nakon intramuskularne primjene ovisi o brzini apsorpcije i procjenjuje se na oko 50 dana.
English: With the other hand, take hold of the cap (A) and carefully tilt back and forth until the cap disconnects and can be pulled off, do not twist (see Figure 1).
Croatian: Drugom rukom primite zatvarač (A) i pažljivo nakrenite naprijed i nazad dok se zatvarač ne odvoji i može se skinuti, ne zakrećite zatvarač. (vidjeti Sliku 1).
English: Studies in animals have shown reproductive toxicity including an increased incidence of foetal abnormalities and deaths (see section 5.3).
Croatian: Istraživanja na životinjama pokazala su reproduktivnu toksičnost, uključujući povećanu incidenciju malformacija i smrti fetusa (vidjeti dio 5.3).
English: There are no long-term data on the effect of fulvestrant on bone.
Croatian: Nema podataka o dugoročnom učinku fulvestranta na kosti.
English: See package leaflet for information on temperature excursions.
Croatian: Vidjeti uputu o lijeku za informacije o temperaturnim odstupanjima.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Faslodex in all subsets of the paediatric population in breast cancer (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Faslodex u svim podskupinama pedijatrijske populacije za rak dojke (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: At steady state, fulvestrant plasma concentrations are maintained within a relatively narrow range with up to an approximately 3-fold difference between maximum and trough concentrations.
Croatian: U stanju dinamičke ravnoteže, koncentracije fulvestranta u plazmi održavaju se unutar relativno uskog raspona, uz do približno trostruku razliku između najviše i najniže koncentracije.
English: • Transport filled syringe to point of administration.
Croatian: • Prenesite napunjenu štrcaljku do mjesta primjene.
English: Any unused medicinal product or waste material should be disposed of in accordance with local requirements (see section 5.3).
Croatian: Neiskorišteni lijek ili otpadni materijal potrebno je zbrinuti sukladno nacionalnim propisima (vidjeti dio 5.3).
English: % of patients with OR; absolute difference in
Croatian: % bolesnika s OR; apsolutna razlika u %
English: • Thick, whitish vaginal discharge and candidiasis (infection)
Croatian: • gusti bjelkasti vaginalni iscjedak i kandidijaza (infekcija)
English: What you need to know before you use Faslodex
Croatian: Što morate znati prije nego počnete primjenjivati Faslodex
English: Faslodex is not indicated for use in children.
Croatian: Faslodex nije namijenjen za primjenu u djece.
English: If pregnancy occurs while taking Faslodex, the patient must be informed of the potential hazard to the foetus and potential risk for loss of pregnancy.
Croatian: Ako tijekom liječenja lijekom Faslodex nastupi trudnoća, bolesnicu se mora upoznati s mogućim opasnostima za fetus i mogućem riziku gubitka ploda.
English: Fifty-five percent (55.0%) of patients had visceral metastasis at baseline.
Croatian: Pedeset i pet posto (55,0%) bolesnica imalo je visceralne metastaze na početku ispitivanja.
English: • Allergic (hypersensitivity) reactions, including swelling of the face, lips, tongue and/or throat
Croatian: • alergijske reakcije (reakcije preosjetljivosti), uključujući oticanje lica, usana, jezika i/ili grla
English: N=number of patients; CI=confidence interval; OR= objective response; TTR=time to first tumour response.
Croatian: N=broj bolesnica; CI=interval pouzdanosti; OR=objektivni odgovor; TTR=vrijeme do prvog tumorskog odgovora.
English: The majority of patients (87.0%) had metastatic disease at baseline.
Croatian: Većina bolesnica (87,0%) imala je metastatsku bolest na početku ispitivanja.
English: Table 2 Adverse reactions based on PALOMA3 Study (N=517)
Croatian: Tablica 2 Nuspojave iz ispitivanja PALOMA3 (N=517)
English: • Increase of gamma-GT, a liver enzyme seen in a blood test
Croatian: • povišene vrijednosti gama-GT, jetrenog enzima, što će biti vidljivo iz krvnih pretraga
English: The descriptions included below are based on the safety analysis set of 228 patients who received at least one (1) dose of fulvestrant and 232 patients who received at least one (1) dose of anastrozole, respectively in the Phase 3 FALCON study.
Croatian: Opisi u nastavku temelje se na analizi podataka o sigurnosti prikupljenih u 228 bolesnica koje su primile najmanje jednu (1) dozu fulvestranta i 232 bolesnice koje su primile najmanje jednu (1) dozu anastrozola u ispitivanju faze 3 FALCON.
English: The objective response rate for Faslodex 250 mg was 19.2% compared with 16.5% for anastrozole.
Croatian: Stopa objektivnog odgovora za Faslodex 250 mg iznosila je 19,2%, u usporedbi sa 16,5% za anastrozol.
English: Fulvestrant has a high clearance, 11±1.7 ml/min/kg, suggesting a high hepatic extraction ratio.
Croatian: Fulvestrant ima visoki klirens, 11±1,7 ml/min/kg, što upućuje na visoki udio ekstrakcije u jetri.
English: There was an increased incidence of foetal variations in rabbits (backwards displacement of the pelvic girdle and 27 pre-sacral vertebrae).
Croatian: Zabilježena je povećana incidencija fetalnih varijacija u kunića (zdjelični obruč i 27. predsakralni kralježak pomaknuti unazad).
English: The recommended dose is 500 mg at intervals of one month, with an additional 500 mg dose given two weeks after the initial dose.
Croatian: Preporučena doza je 500 mg u razmacima od mjesec dana, uz jednu dodatnu dozu od 500 mg koja se daje dva tjedna nakon inicijalne doze.
English: Faslodex is not expected to affect your ability to drive or use machines.
Croatian: Ne očekuje se da bi Faslodex mogao utjecati na sposobnost vožnje i rada sa strojevima.
English: Median duration of exposure to palbociclib in the fulvestrant + palbociclib arm was 10.8 months.
Croatian: Medijan trajanja izloženosti palbociklibu u skupini koja je primala fulvestrant + palbociklib iznosio je 10,8 mjeseci.
English: Temperature excursions outside 2°C - 8°C should be limited.
Croatian: Treba ograničiti temperaturna odstupanja od raspona 2°C - 8°C.
English: Induction of such tumours is consistent with pharmacology-related endocrine feedback alterations in gonadotropin levels caused by antiestrogens in cycling animals.
Croatian: Poticaj nastanka takvih tumora sukladan je farmakološki uvjetovanim promjenama endokrinog odgovora u koncentracijama gonadotropina, koje uzrokuju antiestrogeni u životinja s ciklusom.
English: Thromboembolic events are commonly observed in women with advanced breast cancer and have been observed in clinical studies with Faslodex (see section 4.8).
Croatian: Tromboembolijski događaji su često primijećeni u žena s uznapredovalim rakom dojke i bili su zabilježeni u kliničkim ispitivanjima s Faslodexom (vidjeti dio 4.8).
English: After administration of Faslodex long-acting intramuscular injection, fulvestrant is slowly absorbed and maximum plasma concentrations (Cmax) are reached after about 5 days.
Croatian: Nakon primjene dugodjelujuće intramuskularne injekcije lijeka Faslodex , fulvestrant se sporo apsorbira te doseže vršne koncentracije u plazmi (Cmax) nakon približno 5 dana.
English: Of the 65 patients in the Faslodex arm, 40% (26/65) of patients reported joint and musculoskeletal pain within the first month of treatment, and 66.2% (43/65) of patients within the first 3 months of treatment.
Croatian: Među 65 bolesnica u skupini liječenoj lijekom Faslodex, 40% (26/65) bolesnica prijavilo je bol u zglobovima, mišićima i kostima unutar prvih mjesec dana liječenja, a njih 66,2% (43/65) unutar prva 3 mjeseca liječenja.
English: The median age of patients enrolled in this study was 57 years (range 29, 88).
Croatian: Medijan dobi bolesnica uključenih u ispitivanje iznosio je 57 godina (raspon: 29 - 88).