FrancophonIA/ELRC3.0 huggingface dataset:
English: The potency of efavirenz in cell culture against viral variants with amino acid substitutions at positions 48, 108, 179, 181 or 236 in RT or variants with amino acid substitutions in the protease was similar to that observed against wild type viral strains.
Croatian: U staničnim kulturama potentnost efavirenza protiv virusnih inačica sa zamijenjenim aminokiselinama na mjestima 48, 108, 179, 181 ili 236 u reverznoj transkriptazi (RT), ili inačica sa zamijenjenim aminokiselinama u proteazi, bila je slična onoj zabilježenoj prema divljim sojevima virusa.
English: St. John's wort (Hypericum perforatum)
Croatian: Gospina trava (Hypericum perforatum)
English: In HIV-1 infected patients (n = 6), the pharmacokinetics of indinavir and efavirenz were generally comparable to these uninfected volunteer data.
Croatian: U bolesnika s HIV-1 infekcijom (n=6), farmakokinetika indinavira i efavirenza općenito je bila usporediva s onom u nezaraženih dobrovoljaca.
English: Cross resistance
Croatian: Križna rezistencija
English: Patients should be advised that if they experience symptoms such as severe depression, psychosis or suicidal ideation, they should contact their doctor immediately to assess the possibility that the symptoms may be related to the use of efavirenz, and if so, to determine whether the risks of continued therapy outweigh the benefits (see section 4.8).
Croatian: Bolesnike se mora savjetovati da se u slučaju pojave simptoma poput teške depresije, psihoze ili suicidalnih misli odmah obrate svom liječniku kako bi se procijenila mogućnost povezanosti simptoma s primjenom efavirenza te ustanovilo nadmašuju li rizici nastavka liječenja njenu korist, ako se povezanost potvrdi (vidjeti dio 4.8).
English: The frequency category of "rare" was defined per A Guideline on Summary of Product Characteristics (SmPC) (rev. 2, Sept 2009) on the basis of an estimated upper bound of the 95% confidence interval for 0 events given the number of patients treated with efavirenz in these clinical trials (n=3,969).
Croatian: Kategorija učestalosti "rijetko" određena je prema smjernicama za Sažetak opisa svojstava lijeka (A Guideline on Summary of Product Characteristics, SmPC; rev. 2. rujna 2009.) na temelju procjene gornje granice 95% tnog intervala pouzdanosti za 0 događaja, uzimajući u obzir broj ispitanika liječenih efavirenzom u tim kliničkim ispitivanjima (n=3969).
English: signs of dizziness, difficulty sleeping, drowsiness, difficulty concentrating or abnormal dreaming.
Croatian: znakove omaglice, poteškoće sa spavanjem, omamaljenost, poteškoće s koncentracijom ili neuobičajene snove.
English: Nervous system symptoms
Croatian: Simptomi živčanog sustava
English: These are listed under Do not take SUSTIVA, at the start of Section 2.
Croatian: Ti su lijekovi navedeni u odlomku Nemojte uzimati lijek SUSTIVA, na početku dijela 2.
English: Limited data suggest there is no clinically significant effect on valproic acid pharmacokinetics.
Croatian: Ograničeni podaci pokazuju da nema klinički značajnog učinka na farmakokinetiku valproične kiseline.
English: Psychiatric disorders common abnormal dreams, anxiety, depression, insomnia*
Croatian: Psihijatrijski poremećaji često neuobičajeni snovi, anksioznost, depresija, nesanica *
English: SUSTIVA must always be taken in combination with other anti-HIV medicines.
Croatian: SUSTIVA se uvijek mora uzimati u kombinaciji s drugim lijekovima protiv HIV-a.
English: This may stop the medicines from working properly, or may make any side effects worse.
Croatian: To može spriječiti puni učinak lijekova ili pogoršati neke nuspojave.
English: Give the mixture to the child as soon as possible, but no more than 30 minutes after mixing.
Croatian: Dijete treba mješavinu uzeti što je prije moguće, a najkasnije 30 minuta nakon miješanja.
English: The dose of nelfinavir was 750 mg given three times a day.
Croatian: Doza nelfinavira bila je 750 mg triput na dan.
English: Approximately 14 - 34% of a radiolabelled dose of efavirenz was recovered in the urine and less than 1% of the dose was excreted in urine as unchanged efavirenz.
Croatian: Približno 14-34% radioaktivno označenog efavirenza pronađeno je u mokraći, a manje od 1% doze izlučuje se mokraćom u nepromijenjenom obliku.
English: In view of the data presented in the reviewed PSUR, the overall risk-benefit balance of efavirenz is therefore considered unchanged in the approved indications provided that the terms of the marketing authorisation are varied as relevant.
Croatian: Stoga se, s obzirom na podatke prikazane u pregledanom PSUR-u, ukupni omjer rizika i koristi efavirenza smatra nepromijenjenim u odobrenim indikacijama, s tim da je uvjete odobrenja za stavljanje lijeka u promet potrebno odgovarajuće izmijeniti.
English: If you had a rash while taking another NNRTI, you may be at a higher risk of getting a rash with SUSTIVA.
Croatian: Ako ste imali osip za vrijeme uzimanja nekog drugog NNRTI-ja, možete imati povećan rizik za dobivanje osipa kod uzimanja lijeka SUSTIVA.
English: c C.I., confidence interval for proportion of patients in response.
Croatian: c C.I., interval pouzdanosti za udio ispitanika koji su odgovorili na liječenje.
English: Bioavailability of hard capsule contents mixed with food vehicles
Croatian: Bioraspoloživost sadržaja tvrde kapsule pomiješanog s hranom
English: Concomitant administration of sofosbuvir/velpatasvir with efavirenz resulted in a reduction (approximately 50%) in the systemic exposure of velpatasvir.
Croatian: Istodobna primjena sofosbuvira/velpatasvira s efavirenzom uzrokovala je smanjenje (približno 50%) sistemske izloženosti velpatasviru.
English: In some cases, your doctor may need to adjust your dose or check your blood levels.
Croatian: U nekim slučajevima liječnik će Vam možda morati prilagoditi dozu ili provjeriti koncentracije lijeka u krvi.
English: Pregnancies have occurred in women taking SUSTIVA while using a contraceptive implant, although it has not been established that the SUSTIVA therapy caused the contraceptive to fail.
Croatian: Trudnoća je nastupila u žena koje su uzimale lijek SUSTIVA i koristile kontracepcijski implantat, premda nije utvrđeno da liječenje lijekom SUSTIVA sprječava djelovanje kontraceptiva.
English: 4 Place 1-2 teaspoons of the food in a small container (illustration a).
Croatian: 4 Stavite 1 - 2 čajne žličice hrane u malu posudu (ilustracija a).
English: It is recommended that efavirenz be taken on an empty stomach.
Croatian: Preporučuje se uzimati efavirenz na prazan želudac.
English: Instructions for capsule sprinkle method:
Croatian: Upute za metodu posipanja sadržaja kapsule:
English: Efavirenz is contraindicated in patients with severe hepatic impairment (see sections 4.3 and 5.2) and not recommended in patients with moderate hepatic impairment because of insufficient data to determine whether dose adjustment is necessary.
Croatian: Efavirenz je kontraindiciran u bolesnika s teškim oštećenjem funkcije jetre (vidjeti dijelove 4.3 i 5.2) i ne preporučuje se u bolesnika s umjerenim oštećenjem jetre jer nema dovoljno podataka na temelju kojih bi se moglo zaključiti je li potrebna prilagodba doze.
English: Dark yellow, capsule-shaped, printed with “SUSTIVA” on both sides.
Croatian: Tamnožute, u obliku kapsule, s otisnutom oznakom “SUSTIVA“ na obje strane.
English: Since no dose recommendation for itraconazole can be made, alternative antifungal treatment should be considered.
Croatian: Budući da se ne može dati preporuka za dozu itrakonazola, mora se razmotriti primjena drugog antifungalnog lijeka.
English: Patients who cannot swallow
Croatian: Bolesnici koji ne mogu progutati kapsulu
English: Table 1: Paediatric dose to be administered once daily*
Croatian: Tablica 1: Doza za djecu koju treba primjenjivati jedanput na dan*
English: Your doctor will check your cholesterol levels and will consider changing the dose of your statin, if needed.
Croatian: Liječnik će Vam provjeriti razine kolesterola u krvi i po potrebi razmotriti promjenu doze statina.
English: If there is evidence of worsening liver disease or persistent elevations of serum transaminases to greater than 5 times the upper limit of the normal range, the benefit of continued therapy with efavirenz needs to be weighed against the potential risks of significant liver toxicity.
Croatian: Primijete li se znakovi pogoršanja bolesti jetre ili su vrijednosti serumskih transaminaza trajno povišene više od 5 puta iznad gornje granice normale, treba procijeniti korist nastavka liječenja efavirenzom u odnosu na mogući rizik značajnog toksičnog oštećenja jetre.
English: In HIV-1 infected patients (n = 9) who received efavirenz 200 to 600 mg once daily for at least one month, cerebrospinal fluid concentrations ranged from 0.26 to 1.19% (mean 0.69%) of the corresponding plasma concentration.
Croatian: U bolesnika zaraženih HIV-1 virusom (n=9) koji su primali efavirenz u dozama od 200 do 600 mg jedanput na dan tijekom najmanje mjesec dana, koncentracije lijeka u cerebrospinalnoj tekućini kretale su se u rasponu od 0,26-1,19% (srednja vrijednost 0,69%) odgovarajućih koncentracija u plazmi.
English: This mutation was observed in 90% of patients receiving efavirenz with virological failure.
Croatian: Ova je mutacija zapažena u 90% bolesnika koji su primali efavirenz bez virološkog odgovora.
English: Patients with mild liver disease may be treated with their normally recommended dose of efavirenz.
Croatian: Bolesnici s blagom bolešću jetre mogu se liječiti uobičajenim preporučenim dozama efavirenza.
English: Rash was reported in 59 of 182 children (32%) treated with efavirenz and was severe in six patients.
Croatian: Osip je prijavljen u 59 od 182 djece (32%) liječene efavirenzom, a u šestero bolesnika je bio težak.
English: Efavirenz is a non-competitive inhibitor of HIV-1 reverse transcriptase (RT) and does not significantly inhibit HIV-2 RT or cellular DNA polymerases (α, β, γ or δ).
Croatian: Efavirenz je nekompetitivni inhibitor reverzne transkriptaze HIV-1, bez značajne inhibicije reverzne transkriptaze HIV 2 i staničnih DNK polimeraza (α, β, γ ili δ).
English: Since fluoxetine shares a similar metabolic profile with paroxetine, i.e. a strong CYP2D6 inhibitory effect, a similar lack of interaction would be expected for fluoxetine.
Croatian: Kako fluoksetin ima sličan metabolički profil paroksetinu, tj. jak inhibitorni učinak na CYP2D6, može se očekivati sličan izostanak interakcija za fluoksetin.
English: Severe rash associated with blistering, moist desquamation or ulceration has been reported in less than 1% of patients treated with efavirenz.
Croatian: Jak osip praćen nastajanjem mjehurića, vlažnom deskvamacijom ili ulceracijama prijavljen je u manje od 1% bolesnika liječenih efavirenzom.
English: Rare (affects 1 to 10 users in 10,000) itchy rash caused by a reaction to sunlight liver failure, in some cases leading to death or liver transplant, has occurred with efavirenz.
Croatian: Rijetko (javljaju se u 1 do 10 na 10 000 korisnika) osip koji svrbi uzrokovan reakcijom na sunčevu svjetlost kod primjene efavirenza nastupilo je zatajenje jetre, koje je u nekim slučajevima dovelo do smrti ili presađivanja jetre.
English: Lipid disorders should be managed as clinically appropriate.
Croatian: Poremećaje lipida potrebno je prikladno klinički liječiti.
English: SUSTIVA may interact with other medicines, including herbal preparations such as Ginkgo biloba extracts.
Croatian: Moguće su interakcije lijeka SUSTIVA s nekim drugim lijekovima, uključujući biljne pripravke kao što su ekstrakti Ginkga bilobe.
English: Refer to the Summary of Product Characteristics for the medicinal product containing maraviroc.
Croatian: Vidjeti Sažetak opisa svojstava lijeka za lijek koji sadrži maravirok.
English: As of July 2013, the Antiretroviral Pregnancy Registry (APR) has received prospective reports of 904 pregnancies with first trimester exposure to efavirenz-containing regimens, resulting in 766 live births.
Croatian: Antiretroviral Pregnancy Registry, APR) zaprimljena su prospektivna izvješća o praćenju ishoda 904 trudnoće u kojima su trudnice bile izložene režimu liječenja s efavirenzom tijekom prvog tromjesečja trudnoće, a rezultirale su rođenjem 766 žive djece.
English: In the long-term study (006), 1% of patients in each treatment arm discontinued because of liver or biliary system disorders.
Croatian: U dugotrajnom ispitivanju (006) 1% bolesnika iz svake ispitivane skupine prekinulo je liječenje zbog poremećaja u funkciji jetre ili žuči.
English: PHARMACEUTICAL FORM AND CONTENTS 30 hard capsules
Croatian: 4. FARMACEUTSKI OBLIK I SADRŽAJ 30 tvrdih kapsula
English: When efavirenz is co-administered with a calcium channel blocker that is a substrate of the CYP3A4 enzyme, there is a potential for reduction in the plasma concentrations of the calcium channel blocker.
Croatian: Kad se efavirenz primjenjuje istodobno s blokatorom kalcijevih kanala koji se razgrađuje putem enzima CYP3A4, postoji mogućnost sniženja plazmatske koncentracije blokatora kalcijevih kanala.
English: The clinical significance of asymptomatic increases in serum amylase is unknown.
Croatian: Nije poznata klinička važnost asimptomatskog porasta amilaze u serumu.
English: (CYP3A4 enzyme induction)
Croatian: (indukcija CYP3A4 enzima)
English: The dose for adults is 600 mg once daily.
Croatian: Doza lijeka za odrasle je 600 mg jedanput na dan.
English: Tests may show: increased cholesterol in the blood
Croatian: Pretrage mogu pokazati: povišene vrijednosti kolesterola u krvi
English: Breast-feeding should be discontinued during treatment with SUSTIVA.
Croatian: Dojenje treba prekinuti za vrijeme liječenja SUSTIVA.
English: Use of efavirenz in combination with saquinavir as the sole protease inhibitor is not recommended.
Croatian: Ne preporučuje se primjena efavirenza u kombinaciji sa sakvinavirom kao jedinim inhibitorom proteaze.
English: There is no experience in patients with severe renal failure and close safety monitoring is recommended in this population.
Croatian: Budući da nema iskustva s primjenom u bolesnika s teškim zatajenjem bubrega, preporučuje se strogi nadzor bolesnika u toj populaciji.
English: Efavirenz has a relatively long terminal half-life of at least 52 hours after single doses and 4055 hours after multiple doses.
Croatian: Efavirenz ima relativno dugo terminalno poluvrijeme eliminacije od najmanje 52 sata nakon primjene jednokratne doze, odnosno 40-55 sati nakon višekratne primjene.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Croatian: Iako se smatra da je etiologija osteonekroze multifaktorijalna (uključujući uzimanje kortikosteroida, konzumiranje alkohola, jaku imunosupresiju, povećan indeks tjelesne mase), slučajevi osteonekroze prijavljeni su osobito u bolesnika s uznapredovalom HIV bolešću i/ili u bolesnika izloženih dugotrajnoj kombiniranoj antiretrovirusnoj terapiji.
English: With efavirenz, an increase of the lopinavir/ritonavir soft capsule or oral solution doses by 33% should be considered (4 capsules/~6.5 ml twice daily instead of 3 capsules/5 ml twice daily).
Croatian: Uz efavirenz mora se razmotriti povećanje doze lopinavir/ritonavir mekih kapsula ili oralne otopine za 33% (4 kapsule/~6,5 ml dvaput na dan umjesto 3 kapsule/5 ml dvaput na dan).
English: Diltiazem or similar medicines (called calcium channel blockers which are medicines typically used for high blood pressure or heart problems): when you start taking SUSTIVA, your doctor may need to adjust your dose of the calcium channel blocker.
Croatian: diltiazem ili slične lijekove (koji se zovu blokatori kalcijevih kanala, to su lijekovi koji se obično primjenjuju kod povišenog krvnog tlaka ili srčanih tegoba): kada počnete uzimati lijek SUSTIVA, liječnik će Vam možda trebati prilagoditi dozu blokatora kalcijevih kanala.
English: Outer carton PC:
Croatian: Kutija PC:
English: The safety and efficacy of efavirenz has not been established in patients with significant underlying liver disorders.
Croatian: Sigurnost i djelotvornost efavirenza nisu utvrđene u bolesnika sa značajnim podležećim poremećajima funkcije jetre.
English: Carbamazepine plasma levels should be monitored periodically.
Croatian: Periodički se mora kontrolirati koncentracija karbamazepina u plazmi.
English: In most patients rash resolves with continuing therapy with efavirenz within one month.
Croatian: U većine bolesnika osip se s nastavkom liječenja efavirenzom povlači unutar mjesec dana.
English: In a study of uninfected volunteers, a representative nervous system symptom had a median time to onset of 1 hour post-dose and a median duration of 3 hours.
Croatian: U ispitivanju nezaraženih dobrovoljaca tipični simptomi živčanog sustava javljali su se s medijanom vremena pojave od 1 sat nakon uzimanja lijeka i s medijanom trajanja od 3 sata.
English: Patients who are receiving concomitant anticonvulsant medicinal products primarily metabolised by the liver, such as phenytoin, carbamazepine and phenobarbital, may require periodic monitoring of plasma levels.
Croatian: Bolesnicima koji istodobno primaju antikonvulzivne lijekove koji se primarno razgrađuju u jetri, kao što su fenitoin, karbamazepin i fenobarbital, potrebno je periodički kontrolirati koncentracije u plazmi.
English: UNIQUE IDENTIFIED - HUMAN READABLE DATA
Croatian: JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM
English: Symptoms including, but not limited to, dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming are frequently reported adverse reactions in patients receiving efavirenz 600 mg daily in clinical studies (see section 4.8).
Croatian: Simptomi poput omaglice, nesanice, somnolencije, poremećene koncentracije i neuobičajenih snova, ali i drugi simptomi, često su prijavljivane nuspojave u bolesnika koji su u kliničkim ispitivanjima primali efavirenz u dozi od 600 mg na dan (vidjeti dio 4.8).
English: Efavirenz has also been shown to induce UGT1A1.
Croatian: Utvrđeno je i da efavirenz inducira UGT1A1.
English: In clinical controlled trials, frequently reported adverse reactions included, but were not limited to dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming.
Croatian: U kontroliranim kliničkim ispitivanjima često su zabilježene sljedeće nuspojave (ali ne samo one): omaglica, nesanica, somnolencija, smanjena koncentracija i neuobičajeni snovi.
English: Patients with a history of psychiatric disorders appear to be at greater risk of these serious psychiatric adverse reactions with frequencies ranging from 0.3% for manic reactions to 2.0% for both severe depression and suicidal ideation.
Croatian: Čini se da bolesnici koji su u anamnezi imali psihijatrijske poremećaje imaju veći rizik za razvoj ovih ozbiljnih psihijatrijskih nuspojava, čija se učestalost u njih kreće od 0,3% za manične reakcije do 2,0% za tešku depresiju i suicidalne misli.
English: Patients should be monitored carefully for dose-related adverse reactions, especially nervous system symptoms.
Croatian: Te bolesnike se mora pažljivo pratiti zbog nuspojava ovisnih o dozi, osobito simptoma živčanog sustava.
English: NNRTIs/Efavirenz
Croatian: NNRTI/efavirenz
English: The effect of efavirenz on the QTc interval was evaluated in an open-label, positive and placebo controlled, fixed single sequence 3-period, 3-treatment crossover QT study in 58 healthy subjects enriched for CYP2B6 polymorphisms.
Croatian: Učinak efavirenza na QTc interval bio je procijenjen u otvorenom, pozitivnom i placebom kontroliranom ukriženom ispitivanju 3 vrste liječenja u 3 razdoblja s jednim fiksnim slijedom u 58 zdravih ispitanika s izraženim polimorfizmom CYP2B6.
English: rare delusion ‡, neurosis ‡, completed suicide‡,*
Croatian: rijetko deluzije ‡, neuroza ‡, počinjeno samoubojstvo‡,*
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT
Croatian: 6. POSEBNO UPOZORENJE DA LIJEK TREBA ČUVATI IZVAN POGLEDA
English: Intermittent monotherapy and sequential reintroduction of antiretroviral agents is not advisable because of the increased potential for selection of resistant virus.
Croatian: Ne preporučuje se intermitentna monoterapija niti sekvencijalno ponovno uvođenje antiretrovirusnih lijekova zbog povećane mogućnosti selekcije rezistentnog virusa.
English: Cardiac Electrophysiology
Croatian: Elektrofiziologija srca
English: The inducing effect of St. John's wort may persist for at least 2 weeks after cessation of treatment (see section 4.3).
Croatian: Inducirajući učinak gospine trave može potrajati najmanje 2 tjedna nakon prestanka primjene (vidjeti dio 4.3).
English: Rosuvastatin is largely excreted unchanged via the faeces, therefore interaction with efavirenz is not expected.
Croatian: Rosuvastatin se uglavnom izlučuje neizmijenjen putem stolice pa se stoga ne očekuje interakcija s efavirenzom.
English: In a 3-month drug interaction study, no significant differences in MPA pharmacokinetic parameters were found between subjects receiving efavirenz-containing antiretroviral therapy and subjects receiving no antiretroviral therapy.
Croatian: U tromjesečnom ispitivanju interakcije lijekova nisu ustanovljene značajne razlike u farmakokinetičkim parametrima MPA između ispitanika koji su primali antiretrovirusnu terapiju koja je sadržavala efavirenz i ispitanika koji nisu primali antiretrovirusnu terapiju.
English: The steady-state AUC, Cmax and Cmin of the active carbamazepine epoxide metabolite remained unchanged.
Croatian: U stanju dinamičke ravnoteže AUC, Cmax i Cmin aktivnog metabolita karbamazepin epoksida ostali su neizmijenjeni.
English: You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
Croatian: Dok uzimate ovaj lijek i dalje možete prenijeti infekciju HIV-om, iako je tada rizik od prijenosa manji zbog učinkovite antiretrovirusne terapije.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to combination antiretroviral therapy (CART).
Croatian: Prijavljeni su slučajevi osteonekroze, posebno u bolesnika s opće poznatim rizičnim čimbenicima, uznapredovalom HIV bolešću ili kod dugotrajne izloženosti kombiniranoj antiretrovirusnoj terapiji.
English: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Croatian: U nekih bolesnika s uznapredovalom HIV infekcijom (AIDS), koji su već imali oportunističke infekcije, znakovi i simptomi upale od prijašnjih infekcija mogu nastupiti ubrzo nakon početka liječenja HIV-a.
English: Analysis of long-term data showed that, beyond 24 weeks of therapy, the incidences of new-onset nervous system symptoms among efavirenz-treated patients were generally similar to those in the control arm.
Croatian: Analiza podataka iz dugoročnog ispitivanja pokazala je da je nakon 24 tjedna liječenja incidencija novonastalih simptoma živčanog sustava u bolesnika koji su primali efavirenz bila uglavnom slična onoj u kontrolnih ispitanika.
English: The single substitutions which led to the highest resistance to efavirenz in cell culture correspond to a leucine-to-isoleucine change at position 100 (L100I, 17 to 22-fold resistance) and a lysine-to-asparagine at position 103 (K103N, 18 to 33-fold resistance).
Croatian: Pojedinačne zamjene koje su uzrokovale najveću rezistenciju na efavirenz u staničnim kulturama odgovaraju zamjeni leucina izoleucinom na mjestu 100 (L100I, 17 do 22 puta veća rezistencija) i zamjeni lizina asparaginom na mjestu 103 (K103N, 18 do 33 puta veća rezistencija).
English: Efavirenz must not be used as a single agent to treat HIV or added on as a sole agent to a failing regimen.
Croatian: Efavirenz se ne smije primjenjivati kao jedini lijek u liječenju HIV-a niti ga se smije kao jedinog dodavati neučinkovitom režimu liječenja.
English: 8 Sprinkle the contents of the capsule on the food (illustration d).
Croatian: 8 Pospite sadržaj kapsule po hrani (ilustracija d).