FrancophonIA/ELRC3.0 huggingface dataset:
English: In comparative studies a less than 15% reduction in fibrinogen and a less than 25% reduction in plasminogen were observed in subjects treated with the maximum dose of tenecteplase (10,000 U, corresponding to 50 mg), whereas alteplase caused an approximately 50% decrease in fibrinogen and plasminogen levels.
Croatian: U usporednim ispitivanjima, primijećeno je smanjenje fibrinogena za manje od 15%, te smanjenje plazminogena za manje od 25% kod ispitanika liječenih najvišom dozvoljenom dozom tenekteplaze (10 000 U, što odgovara 50 mg), dok je alteplaza dovela do smanjenja od oko 50% u vrijednostima fibrinogena i plazminogena.
English: The mean residence time (MRT) in the body is approximately 1 h and the mean (± SD) volume of distribution at the steady-state (Vss) ranged from 6.3 ± 2 L to 15 ± 7 L.
Croatian: Srednje vrijeme zadržavanja (MRT) u tijelu je oko 1 sat, a srednji (± SD) volumen distribucije u stanju dinamičke ravnoteže (Vss) varirao je od 6,3 ± 2 L do 15 ± 7 L.
English: Tenecteplase induced total litter deaths during the mid-embryonal period.
Croatian: Tenekteplaza je uzrokovala smrt sve mladunčadi tijekom srednjeg embrionalnog razdoblja.
English: The doctor calculates your dose of Metalyseaccording to your bodyweight, based on the following scheme:
Croatian: Liječnik će izračunati odgovarajuću dozu Metalysea prema Vašoj tjelesnoj težini, a na osnovi sljedeće sheme:
English: If primary percutaneous coronary intervention (PCI) is scheduled according to the current relevant treatment guidelines, tenecteplase (see section 5.1 ASSENT-4 study) should not be given.
Croatian: Ukoliko se planira primarna perkutana koronarna intervencija (PCI) prema trenutno važećim terapijskim smjernicama, tenektaplaza (vidjeti dio 5.1 Ispitivanje ASSENT-4) se ne smije primijeniti.
English: Check that the cap of the vial is still intact.
Croatian: Provjerite je li poklopac bočice nedirnut.
English: Frequency groupings are defined according to the following convention: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000), Not known (cannot be estimated from the available data).
Croatian: Kategorije učestalosti definirane su na sljedeći način: vrlo često (≥1/10), često (≥1/100 do <1/10), manje često (≥1/1000 do <1/100), rijetko (≥1/10 000 do <1/1000), vrlo rijetko (<1/10 000), nepoznato (ne može se utvrditi iz dostupnih podataka).
English: Keep the container in the outer carton in order to protect from light.
Croatian: Čuvati spremnik u vanjskoj kutiji radi zaštite od svjetlosti.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before you are given this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego uzmete ovaj lijek.
English: Failure to do so may lead to greater than the required dose of Metalyse being administered.
Croatian: Ako to ne činite, može doći do primjene veće doze Metalysea od preporučene.
English: The bounds of the confidence interval of the observed incidences prior and after dose reduction are overlapping.
Croatian: Granice intervala pouzdanosti primijećenih incidencija prije i poslije snižavanja doze se preklapaju.
English: Ensure that the appropriate vial size is chosen according to the body weight of the patient.
Croatian: Uvjerite se da je izabrana odgovarajuća veličina bočice, prema tjelesnoj težini bolesnika.
English: Metalyse should be administered with caution in the elderly ( 75 years) due to a higher bleeding risk (see information on bleeding in section 4.4 and on the STREAM study in section 5.1).
Croatian: Metalyse je potrebno primjenjivati s oprezom kod starijih osoba ( 75 godina) zbog većeg rizika od krvarenja (vidjeti informacije o krvarenju u dijelu 4.4 i o ispitivanju STREAM u dijelu 5.1).
English: Because elimination of tenecteplase is through the liver, it is not expected that renal dysfunction will affect its the pharmacokinetics.
Croatian: S obzirom da se eliminacija tenekteplaze odvija putem jetre, ne očekuje se utjecaj disfunkcije bubrega na njezinu farmakokinetiku.
English: These cardiovascular events can be life-threatening and may lead to death.
Croatian: Ovi kardiovaskularni događaji mogu biti opasni po život te mogu dovesti do smrti.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeliili biste mogli uzeti bilo koje druge lijekove.
English: КГ - клон България
Croatian: КГклон България
English: With regard to the indication and the single dose administration in humans, reproductive toxicity testing was limited to an embryotoxicity study in rabbits, as a sensitive species.
Croatian: S obzirom na indikaciju i jednokratnu primjenu kod ljudi, ispitivanje reproduktivne toksičnosti bilo je ograničeno na ispitivanje embriotoksičnosti kod zečeva, kao osjetljive vrste.
English: The most common complication encountered during tenecteplase therapy is bleeding.
Croatian: Najčešća komplikacija tijekom liječenja tenekteplazom je krvarenje.
English: Treatment with Metalyse should be initiated as soon as possible after onset of symptoms.
Croatian: Liječenje Metalyseom mora se započeti što je ranije moguće od nastupa simptoma.
English: Any unused solution should be discarded.
Croatian: Neiskorištena otopina se mora zbrinuti.
English: cardiac tamponade, myocardial rupture - rare: pulmonary embolism
Croatian: tamponada srca, ruptura miokarda - rijetko: plućna embolija
English: The initial, dominant half-life is 24 ± 5.5 (mean ±SD) min, which is 5 times longer than native t-PA.
Croatian: Početni, dominantni poluvijek je 24 ± 5,5 (srednja vrijednost ±SD) min, što je 5 puta dulje od fiziološkog t-PA.
English: Tenecteplase is cleared from circulation by binding to specific receptors in the liver followed by catabolism to small peptides.
Croatian: Tenekteplaza se uklanja iz cirkulacije vezanjem na specifične receptore u jetri, iza čega slijedi razgradnja u male peptide.
English: Death and permanent disability are reported in patients who have experienced stroke (including intracranial bleeding) and other serious bleeding episodes.
Croatian: Smrt i trajni invaliditet su zabilježeni kod bolesnika koji su doživjeli moždani udar (uključujći intrakranijalno krvarenje) i ostale epizode teškog krvarenja.
English: In the few patients who fail to respond to these conservative measures, judicious use of transfusion products may be indicated.
Croatian: Kod pojedinih bolesnika koji ne reagiraju na ovakve konzervativne mjere liječenja, treba razmisliti o primjeni transfuzijskih pripravaka.
English: Therefore, thrombolytic therapy requires careful attention to all possible bleeding sites (including catheter insertion sites, arterial and venous puncture sites, cutdown sites and needle puncture sites).
Croatian: Stoga, trombolitička terapija zahtijeva poseban oprez na svim mogućim mjestima krvarenja (uključujući mjesta uvođenja katetera, mjesta intraarterijske i intravenske punkcije, rezove te mjesta punkcije iglom).
English: A pre-existing intravenous line may be used for administration of Metalyse in sodium chloride 9 mg/ml (0.9%) solution only.
Croatian: Već postojeći intravenski put može se koristiti za unos Metalysea samo u otopini natrijeva klorida od 9 mg/ml (0,9%).
English: In case of severe prolonged bleeding substitution therapy may be considered (plasma, platelets), see also section 4.4.
Croatian: U slučaju teškog oblika produljenog krvarenja, potrebno je razmisliti o supstitucijskoj terapiji (plazma, trombociti), također vidjeti dio 4.4.
English: Eye haemorrhage
Croatian: Hemoragija oka
English: However, the effect of renal and hepatic dysfunction on pharmacokinetics of tenecteplase in humans has not been specifically investigated.
Croatian: Međutim, učinak disfunkcije bubrega ili jetre na farmakokinetiku tenekteplaze u ljudi nije posebno ispitivan.
English: Multiple-dose toxicity studies in rats and dogs confirmed these above-mentioned observations, but the study duration was limited to two weeks by antibody formation to the human protein tenecteplase, which resulted in anaphylaxis.
Croatian: Ispitivanja toksičnosti višekratnih doza na štakorima i psima potvrdila su prethodno navedena zapažanja, ali trajanje ispitivanja bilo je ograničeno na dva tjedna, zbog stvaranja antitijela na ljudski protein tenekteplazu, što je rezultiralo anafilaksijom.
English: From a microbiological point of view, the reconstituted solution should be used immediately.
Croatian: S mikrobiološkog stajališta, rekonstituirana otopina se mora primijeniti odmah.
English: As fibrin is lysed during tenecteplase therapy, bleeding from recent puncture site may occur.
Croatian: Kako se fibrin lizira tijekom terapije tenekteplazom, može doći do pojave krvarenja iz mjesta nedavne punkcije iglom.
English: Children and adolescents The use of Metalyse in children and adolescents up to the age of 18 years is not recommended.
Croatian: Djeca i adolescenti Primjena Metalysea kod djece i adolescenata do dobi od 18 godina se ne preporučuje.
English: Transfer the appropriate volume of reconstituted solution of Metalyse into the syringe, based on the patient's weight.
Croatian: Prebacite odgovarajući volumen rekonstituirane otopine Metalysea u štrcaljku, ovisno o težini bolesnika.
English: PARTICULARS TO APPEAR ON THE INNER SIDE OF THE LID OF THE CARTON IN FORM OF A PICTOGRAMM
Croatian: PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJOJ STRANICI POKLOPCA KUTIJE U OBLIKU PIKTOGRAMA
English: It is not known if tenecteplase is excreted in human milk.
Croatian: Nije poznato izlučuje li se tenekteplaza u majčinom mlijeku ljudi.
English: Antifibrinolytic agents are available as a last alternative.
Croatian: Antifibrinolitički lijekovi se primjenjuju kao posljednja mogućnost u liječenju.
English: The trial was prematurely terminated with 1667 randomised patients due to a numerically higher mortality in the facilitated PCI group receiving tenecteplase.
Croatian: Ispitivanje je obustavljeno prije vremena s 1 667 randomiziranih bolesnika, zbog brojčano veće smrtnosti u PCI skupini koja je primala tenekteplazu.
English: Metalyse is used to treat myocardial infarctions (heart attacks) within 6 hours after the onset of symptoms and helps to dissolve the blood clots that have formed in the blood vessels of the heart.
Croatian: Metalyse se primjenjuje u liječenju infarkta miokarda (srčanih udara) unutar 6 sati od nastupa simptoma te pomaže u razgradnji krvnih ugrušaka koji nastaju u krvnim žilama srca.
English: The ASSENT-4 PCI study was designed to show if in 4000 patients with large myocardial infarctions pre-treatment with full dose tenecteplase and concomitant single bolus of up to 4,000 IU unfractionated heparin administered prior to primary PCI to be performed within 60 to 180 minutes leads to better outcomes than primary PCI alone.
Croatian: ASSENT-4 PCI je studija koja je organizirana kako bi pokazala da li kod 4000 bolesnika, koji su imali opsežne infarkte miokarda, prethodno liječenje punom dozom tenekteplaze uz istovremenu primjenu jednokratnog bolusa do 4000 IU nefrakcioniranog heparina primijenjenog prije primarne PCI, koja je trebala biti izvedena unutar 60 do 180 minuta, vodi do boljih rezultata nego sama primarna PCI.
English: This leaflet is available in all EU/EEA languages on the European Medicines Agency website.
Croatian: Ova uputa dostupna je na svim jezicima EU-a/EGP-a na internetskim stranicama Europske agencije za lijekove.
English: Now solution is ready for iv. bolus injection.
Croatian: Sada je otopina spremna za intravensku bolus injekciju.
English: Tel: +49 (0) 800 77 90 900
Croatian: KG Tel: +49 (0) 800 77 90 900
English: Composite death, shock, congestive heart failure, re-infarction
Croatian: Kompozit smrti, šoka, kongestivnog zatajenja srca, ponovnog infarkta
English: Retroperitoneal haemorrhage (such as retroperitoneal haematoma)
Croatian: Retroperitonealno krvarenje (kao što je retroperitonealni haematom)
English: Accordingly, there is no guidance for the adjustment to tenecteplase dose in patients with hepatic and severe renal insufficiency.
Croatian: Shodno tome, ne postoji smjernica za prilagodbu doze tenekteplaze kod bolesnika s insuficijencijom jetre i teškom insuficijencijom bubrega.
English: Most frequently haemorrhage at the injection site, and occasionally genitourinary and gingival bleeding were observed.
Croatian: Najčešće zabilježena krvarenja su na mjestima primjene injekcije, a povremeno je primijećeno genitourinarno, te gingivalno krvarenje.
English: Potency of tenecteplase is expressed in units (U) by using a reference standard which is specific for tenecteplase and is not comparable with units used for other thrombolytic agents.
Croatian: Aktivnost tenekteplaze izražena je u jedinicama (U) pomoću referentnog standarda, koji je specifičan za tenekteplazu te nije usporediv s jedinicama koje se primjenjuju za druge trombolitičke lijekove.
English: Medicinal products that affect coagulation or those that alter platelet function (e.g. ticlopidine, clopidogrel, LMWH) may increase the risk of bleeding prior to, during or after tenecteplase therapy.
Croatian: Lijekovi koji utječu na koagulaciju ili oni koji mijenjaju funkciju trombocita (npr. tiklopidin, klopidogrel, LMWH) mogu povećati rizik od krvarenja prije, tijekom, ili nakon liječenja tenekteplazom.
English: No sustained antibody formation to the tenecteplase molecule has been observed after treatment.
Croatian: Nije primijećeno stvaranje antitijela na molekulu tenekteplaze nakon liječenja.
English: The required dose should be administered as a single intravenous bolus over approximately 10 seconds.
Croatian: Potrebna doza primjenjuje se u obliku jednokratnog intravenskog bolusa tijekom otprilike 10 sekundi.
English: Patients who cannot undergo primary PCI within one hour as recommended by guidelines and receive tenecteplase as primary coronary recanalization treatment should be transferred without delay to a coronary intervention capable facility for angiography and timely adjunctive coronary intervention within 6-24 hours or earlier if medically indicated (see section 5.1 STREAM study).
Croatian: Bolesnici koji ne mogu biti podvrgnuti primarnom PCI-u unutar jednog sata, kao što je preporučeno u smjernicama, i koji primaju tenekteplazu za primarnu koronarnu rekanalizaciju moraju, bez odgode, biti prebačeni na odjel opremeljen za kornarnu intervenciju radi angiografije i pravovremene dodatne kornarne intervencije u roku 6-24 sata ili ranije ukoliko postoji medicinska indikacija (vidjeti dio 5.1 Ispitivanje STREAM).
English: If an anaphylactoid reaction occurs, the injection should be discontinued immediately and appropriate therapy should be initiated.
Croatian: Ukoliko dođe do pojave anafilaktoidne reakcije, potrebno je trenutno prekinuti primjenu injekcije te započeti odgovarajuće liječenje.
English: In case of bleeding in the brain events related to the nervous system have been reported e.g. drowsiness (somnolence), speech disorders, palsy of parts of the body (hemiparesis) and fits (convulsions).
Croatian: U slučaju krvarenja u mozgu, prijavljeni su događaji povezani sa živčanim sustavom, npr. pospanost (somnolencija), poremećaji govora, paraliza dijelova tijela (hemipareza) i napadaji (konvulzije).
English: Intravenous single dose administration in rats, rabbits and dogs resulted only in dose-dependent and reversible alterations of the coagulation parameters with local haemorrhage at the injection site, which was regarded as a consequence of the pharmacodynamic effect of tenecteplase.
Croatian: Jednokratno intravenski primijenjena doza na štakorima, zečevima i psima rezultirala je, samo ovisno o dozi, reverzibilnim promjenama koagualcijskih parametara, uz lokalno krvarenje na mjestu primjene injekcije, što se smatralo posljedicom farmakodinamičkog učinka tenekteplaze.
English: Metalyse should be administered on the basis of body weight, with a maximum dose of 10,000 units (50 mg tenecteplase).
Croatian: Metalyse treba primijeniti na temelju tjelesne težine, do najviše dozvoljene doze od 10 000 jedinica (50 mg tenekteplaze).
English: Not known(frequency cannot be estimated from the available data): fat embolism (clots consisting of fat) nausea vomiting body temperature increased (fever) blood transfusions as consequence of bleedings
Croatian: Nepoznato (učestalost se ne može utvrditi iz dostupnih podataka): - masna embolija (ugrušci od masnoća) - mučnina - povraćanje - povišena tjelesna temperatura (vrućica) - transfuzije krvi kao posljedica krvarenja
English: Tenecteplase is a recombinant fibrin-specific plasminogen activator.
Croatian: Tenekteplaza je rekombinantni fibrin-specifični aktivator plazminogena.
English: The other ingredients are L-arginine, phosphoric acid and polysorbate 20.
Croatian: - Drugi sastojci su: L-arginin, fosfatna kiselina i polisorbat 20 -
English: Once Metalysehas been reconstituted it may be stored for 24 hours at 2-8°C and 8 hours at 30°C.
Croatian: Kada se Metalyse jednom pripremi za primjenu, može se čuvati do 24 sata na temperaturi od 2-8
English: The concomitant use of heparin anticoagulation may contribute to bleeding.
Croatian: Istovremena primjena heparina može pridonijeti krvarenju.
English: Very common (may affect more than 1 in 10 people): bleeding
Croatian: Vrlo često (mogu se javiti u više od 1 na 10 osoba): - krvarenje
English: Binding to hepatic receptors is, however, reduced compared to native tPA, resulting in a prolonged half-life.
Croatian: Vezanje na jetrene receptore je, međutim, smanjeno u odnosu na fiziološki t-PA, što rezultira produljenim poluvijekom.
English: Chemical and physical in-use stability has been demonstrated for 24 hours at 2-8°C and 8 hours at 30°C.
Croatian: Dokazana kemijska i fizikalna stabilnost u primjeni je 24 sata na 2 -8
English: The pharmaco-invasive strategy consisted of early fibrinolytic treatment with bolus tenecteplase and additional antiplatelet and anticoagulant therapy followed by angiography within 6-24 hours or rescue coronary intervention.
Croatian: Farmakoinvazivna strategija obuhvaćala je rano fibrinolitičko liječenje tenekteplazom u bolusu i dodatno antitrombocitno i antikoagulacijsko liječenje iza čega je slijedila angiografija u roku 6-24 sata ili „rescue“ (spasonosna) koronarna intervencija.
English: If treatment with Metalyse is nevertheless considered to be necessary, facilities for reanimation should be immediately available in case of need;
Croatian: Ako se liječenje Metalyseom ipak smatra neophodnim, odmah je potrebno osigurati dostupnost opreme za reanimaciju, za slučaj potrebe;
English: Clinical data as well as nonclinical studies on fertility are not available for tenecteplase (Metalyse).
Croatian: Ne postoje klinički podaci niti su provođena neklinička ispitivanja plodnosti s tenekteplazom (Metalyse).
English: Metalyse should be reconstituted by adding the complete volume of water for injections from the prefilled syringe to the vial containing the powder for injection.
Croatian: Metalyse se rekonstituira dodavanjem cijelog volumena vode za injekcije iz napunjene štrcaljke u bočicu koja sadrži prašak za injekciju.
English: There is no dose dependence of tenecteplase clearance in the therapeutic dose range.
Croatian: Ne postoji ovisnost klirensa tenkteplaze o dozi pri terapijskim dozama.
English: After single intravenous bolus injection of tenecteplase in patients with acute myocardial infarction, tenecteplase antigen exhibits biphasic elimination from plasma.
Croatian: Nakon jednokratne intravenske bolus injekcije tenekteplaze, kod bolesnika s akutnim infarktom miokarda, antigen tenekteplaze pokazuje bifaznu eliminaciju iz plazme.
English: Increasing body weight resulted in a moderate increase of tenecteplase clearance, and increasing age resulted in a slight decrease of clearance.
Croatian: Povećanje tjelesne težine rezultira umjerenim povećanjem klirensa tenekteplaze, a sa starijom dobi dolazi do neznatnog smanjenja klirensa.
English: Single components of the primary composite endpoint for the pharmaco-invasive strategy versus primary PCI respectively were observed with the following frequencies:
Croatian: Pojedine komponente primarnog kompozitnog ishoda za farmako-invazivnu strategiju naspram primarnog PCI-a primijećene su uz sljedeću učestalost:
English: Invert vial/syringe and transfer the appropriate volume of the solution into syringe according to the dosing instructions.
Croatian: Preokrenite bočicu/štrcaljku i prebacite odgovarajući volumen otopine u štrcaljku sukladno uputama za doziranje.
English: SPECIAL STORAGE CONDITIONS Keep the container in the outer carton.
Croatian: POSEBNE MJERE ČUVANJA Čuvati spremnik u vanjskoj kutiji.
English: SPECIAL STORAGE CONDITIONS Do not store above 30C.
Croatian: POSEBNE MJERE ČUVANJA Ne čuvati na temperaturi iznad 30ºC.
English: The dose linearity analysis based on AUC suggested that tenecteplase exhibits non-linear pharmacokinetics in the dose range studied, i.e. 5 to 50 mg.
Croatian: Analiza linearnosti doze na osnovi AUC-a pokazala je nelinearnu farmakokinetiku tenekteplaze u ispitivanom rapsonu doza, tj. od 5 do 50 mg.
English: If treatment with Metalyse is nevertheless considered to be necessary, facilities for resuscitation should be immediately available in case of need.
Croatian: Ako se liječenje Metalyseom ipak smatra nužnim, odmah se mora osigurati dostupna oprema za reanimaciju, u slučaju potrebe.
English: Anaphylactoid reaction (including rash, urticaria, bronchospasm, laryngeal oedema)
Croatian: Anafilaktoidne reakcije (uključujući osip, urtikariju, bronhospazam, edem larinksa)
English: Safety pharmacology data in cynomolgus monkeys revealed reduction of blood pressure followed by changes of ECG, but these occurred at exposures that were considerably higher than the clinical exposure.
Croatian: Farmakološki podaci o neškodljivosti kod majmuna (vrsta cynomolgus) otkrili su sniženje krvnog tlaka popraćenog promjenama u EKG-u, ali ova je pojava zabilježena pri puno višim dozama u usporedbi s kliničkom izloženosti.
English: Reperfusion arrhythmias (such as asystole, accelerated idioventricular arrhythmia, arrhythmia, extrasystoles, atrial fibrillation, atrioventricular first degree to atrioventricular block complete, bradycardia, tachycardia, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia) occur in close temporal relationship to treatment with tenecteplase.
Croatian: Reperfuzijske aritmije (kao što su asistola, ubrzana idioventrikularna aritmija, aritmija, ekstrasistole, fibrilacija atrija, atrioventrikularni blok prvog stupnja do totalnog atrioventrikularnog bloka, bradikardija, tahikardija, ventrikularna aritmija, fibrilacija ventrikula, ventrikularna tahikardija) pojavljuju se u uskoj vremenskoj povezanosti s liječenjem tenekteplazom.
English: Metalyse is to be administered to the patient, intravenously in about 10 seconds.
Croatian: 11. Metalyse treba davati bolesniku intravenski tijekom 10 sekundi.
English: It is recommended that antiarrhythmic therapy for bradycardia and/or ventricular tachyarrhythmias (pacemaker, defibrillator) is available when tenecteplase is administered.
Croatian: Preporučuje se dostupnost antiaritmijske terapije za bradikardiju i/ili ventrikulsku tahiaritmiju (elektrostimulator, defibrilator) tijekom primjene tenekteplaze.
English: There is limited amount of data from the use of Metalyse in pregnant women.
Croatian: Podaci o primjeni Metalysea u trudnica su ograničeni.
English: After administration of tenecteplase dose dependent consumption of 2-antiplasmin (the fluid-phase inhibitor of plasmin) with consequent increase in the level of systemic plasmin generation have been observed.
Croatian: Nakon primjene tenekteplaze, primijećena je, o dozi ovisna potrošnja α2-antiplazmina (inhibitora plazmina u tekućoj fazi) s posljedičnim porastom nivoa sistemski nakupljenog plazmina.
English: The reconstituted preparation is a clear and colourless to slightly yellow solution.
Croatian: Rekonstituirani pripravak je bistra i bezbojna do blago žuta otopina.