FrancophonIA/ELRC3.0 huggingface dataset:
English: % with Category C 48.4% Treatment history % with any ARV 96.8% Median # previous
Croatian: % sa skupinom C 48,4% Anamneza liječenja % s bilo kojim ARV medijan broja prethodnih NRTI medijan broja prethodnih NNRTI medijan broja prethodnih IP * ADI - AIDS defining illness: stanje koje definira AIDS
English: Fever - Weight loss - Increased blood levels of the pancreas enzyme amylase - Increases in liver enzyme activity - Hepatitis with liver cell damage due to influence of a toxin
Croatian: - povećanja aktivnosti jetrenog enzima - hepatitis s oštećenjem jetrene stanice zbog utjecaja toksina
English: Among all randomised and treated patients, the median change from baseline in CD4+ cell count at the last measurement up to Week 48 was +23 cells/mm
Croatian: Uzimajući u obzir sve randomizirane i liječene bolesnike medijan razlike broja CD4+ stanica između zadnjeg mjerenja (najdulje nakon 48 tjedana) i vrijednosti prije početka liječenja, iznosio je +23 stanice/mm
English: Common: may affect up to 1 in 10 people - Vomiting - Abdominal pain (tummy pain) - Flatulence (breaking wind more often) - Tiredness - Headache - Mild rashes e.g. with hives or with flat or raised small red spots - Increases in blood lipid (fat) levels - Dyspepsia
Croatian: Često: mogu se javiti u do 1 na 10 osoba - povraćanje - abdominalna bol (bol u trbuhu) - nadutost (često puštanje vjetrova) - umor - glavobolja - blagi osipi, npr. uz koprivnjaču, ili ravne ili izbočene male crvene mrlje - povišenje vrijednosti lipida (masnoće) u krvi - dispepsija
English: The co-administration of tipranavir with vitamin E in the form of TPGS (d-alphatocopherol polyethylene glycol 1000 succinate) from 2,322 IU/m² upwards in rats resulted in a significant increase in effects on coagulation parameters, bleeding events and death.
Croatian: Krvarenje primijećeno na štakorima bilo je povezano s produljenim protrombinskim vremenom (PV), aktiviranim parcijalnim tromboplastinskim vremenom (APTV) i smanjenjem nekih faktora ovisnih o vitaminu K. Istodobna primjena tipranavira s vitaminom E u obliku TPGS-a (dalfatokoferol polietilenglikol 1000 sukcinat), u dozi od 2,322 IU/m² naviše, u štakora je rezultirala značajnim povećanjem učinaka na parametre koagulacije, krvarenja i smrt.
English: The combined use of Aptivus with ritonavir with either omeprazole, esomeprazole or with other proton pump inhibitors is not recommended (see section 4.5).
Croatian: Kombinirana primjena Aptivusa s ritonavirom i omeprazola, esomeprazola, ili drugih inhibitora protonske pumpe se ne preporuča (vidjeti dio 4.5).
English: NAME OF THE MEDICINAL PRODUCT Aptivus 100 mg/ml oral solution tipranavir
Croatian: NAZIV LIJEKA Aptivus 100 mg/ml oralna otopina tipranavir
English: Patients treated with Aptivus and reaching the age of 12 years should be switched to the capsule formulation (see sections 4.4 and 5.1).
Croatian: Djeca koja navršavaju 12 godina nastavljaju liječenje Aptivus kapsulama (vidjeti dijelove 4.4 i 5.1).
English: MARKETING AUTHORISATION NUMBER(S) EU/1/05/315/002
Croatian: 12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/05/315/002
English: Inhibition of CYP 2C9 with firstdose tipranavir /r, then induction of CYP 2C9 with steady-state tipranavir/r
Croatian: Inhibicija CYP 2C9 prvom dozom tipranavira/r, zatim indukcija CYP 2C9 tipranavirom/r u stanju ravnoteže
English: Based on theoretical considerations, tipranavir, co-administered with low dose ritonavir, is expected to increase dihydroergotamine, ergonovine, ergotamine and methylergonovine concentrations.
Croatian: Temeljem teoretskih razmatranja, očekuje se da tipranavir s niskom dozom ritonavira povećava koncentracije dihidroergotamina, ergonovina, ergotamina i metilergonovina.
English: Since levels of ethinyl oestradiol are decreased, the co-administration of Aptivus co-administered with low dose ritonavir is not recommended.
Croatian: S obzirom da su vrijednosti etinilestradiola snižene, istodobna primjena Aptivusa s niskom dozom ritonavira se ne preporuča.
English: Your child should continue to take Aptivus for as long as your child's doctor tells him/her.
Croatian: Vaše dijete treba nastaviti uzimati Aptivus toliko dugo koliko je propisao djetetov liječnik.
English: In both studies, a total of 67% patient viruses were resistant and 22% were possibly resistant to the pre-selected comparator PIs.
Croatian: Medijan prethodno rabljenih NRTI-a iznosio je 6, NNRTI-a 1 i IP-a 4. U oba ispitivanja, ukupno 67% bolesnika imalo je rezistentne viruse, a 22% moguće rezistentne na prethodno odabrane kontrolne IP.
English: propylene glycol, mono/diglycerides of caprylic/capric acid, sucralose, ascorbic acid, Butter
Croatian: mono/digliceridi kaprilatne/kaprinske kiseline, sukraloza, askorbatna kiselina, okusi maslaca metvice i maslaca karamele.
English: - If you have any further questions, please ask your child's doctor or pharmacist.
Croatian: Ako imate dodatnih pitanja, obratite se djetetovom liječniku ili ljekarniku.
English: Transient inhibition of P-gp by tipranavir/r, followed by induction of P-gp by tipranavir/r at steadystate
Croatian: Prolazna inhibicija P-gp putem tipranavira/r, iza čega slijedi indukcija P-gp putem tipranavira/r u stanju ravnoteže
English: 150 mg/m 2 ritonavir, twice daily.
Croatian: 500 mg uz ritonavir 200 mg.
English: In one particular in vitro resistance experiment, an HIV-1 isolate that was 87-fold resistant to tipranavir was selected after 9 months, and contained 10 mutations in the protease: L10F, I13V, V32I, L33F, M36I, K45I, I54V/T, A71V, V82L, I84V as well as a mutation in the gag polyprotein CA/P2 cleavage site.
Croatian: U jednom in vitro ispitivanju, HIV-1 izolat, koji je bio 87 puta otporniji na tipranavir (od uobičajeno osjetljivih sojeva) odabran je nakon 9 mjeseci, te je sadržavao 10 mutacija u proteazi: L10F, I13V, V32I, L33F, M36I, K45I, I54V/T, A71V, V82L, I84V kao i mutaciju na gag poliproteinskom CA/P2 mjestu na kojem tipranavir cijepa proteazu.
English: Concomitant administration of Aptivus, co-administered with low dose ritonavir, and these glucocorticoids is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4).
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i ovih glukokortikoida se ne preporučuju, osim ako potencijalni pozitivni učinci liječenja ne nadilaze rizik od sistemskih kortikosteroidnih učinaka (vidjeti dio 4.4).
English: Through a series of multiple stepwise regression analyses of baseline and on-treatment genotypes from all clinical studies, 16 amino acids have been associated with reduced tipranavir susceptibility and/or reduced 48-week viral load response: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D and 84V.
Croatian: Stupnjevita multivarijatna regresijska analiza združenosti genotipova (određenih na početku liječenja ili tijekom liječenja) i terapijskog odgovora ukazala je da je 16 aminokiselina združeno sa smanjenom osjetljivošću na tipranavir i/ili sa manjim odgovorom u smislu broja virusnih replika nakon 48 tjedana liječenja: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D i 84V.
English: Liver monitoring
Croatian: Praćenje funkcije jetre
English: Digoxin 0.25 mg QD iv
Croatian: Digoksin 0,25 mg QD i.v.
English: NAME OF THE MEDICINAL PRODUCT Aptivus 100 mg/ml oral solution
Croatian: NAZIV LIJEKA Aptivus 100 mg/ml oralna otopina
English: Therefore, the concomitant use of zidovudine or abacavir with Aptivus, co-administered with low dose ritonavir, is not-recommended unless there are no other available NRTIs suitable for patient management (see section 4.5).
Croatian: Stoga se istodobna primjena zidovudina ili abakavira s Aptivusom, uz nisku dozu ritonavira, ne preporuča, osim ako su oni jedini NRTI prikladni za zbrinjavanje bolesnika (vidjeti dio 4.5).
English: The most frequently reported moderate or severe adverse reactions in the 48 week analyses are noted below.
Croatian: Najčešće umjerene do teške nuspojave zabilježene tijekom 48 tjedana navedene su u tablici.
English: Co-administration of etravirine and Aptivus/ritonavir is not recommended.
Croatian: Istodobna primjena etravirina i Aptivusa/ritonavira se ne preporučuje.
English: Due to the marked hepatotoxicity of bosentan and the potential for increasing the liver toxicity associated with Aptivus,co-administered with low dose ritonavir, this combination is not recommended.
Croatian: Zbog izražene hepatotoksičnosti bosentana i moguće povećane hepatotoksičnosti Aptivusa s niskom dozom ritonavira, ova kombinacija se ne preporučuje.
English: These medicines are used to treat anxiety or sleep disorders - ergot derivatives (used to treat headaches) - astemizole or terfenadine (used to treat allergies or hay fever) - simvastatin or lovastatin (used to lower blood cholesterol) - amiodarone, bepridil, flecainide, propafenone or quinidine (used to treat heart disorders) - metoprolol (used to treat heart failure) - alfuzosin and sildenafil (when used to treat a rare blood vessel disorder characterized by increased pressure in the pulmonary artery) - colchicine (when used to treat gout flares in patients with kidney or liver disease).
Croatian: Ovi lijekovi se primjenjuju u liječenju anksioznosti ili poremećaja spavanja - derivate ergota (primjenjuju se u liječenju glavobolja) - astemizol ili terfenadin (primjenjuju se u liječenju alergija ili peludne groznice) - simvastatin ili lovastatin (primjenjuju se za snižavanje kolesterola u krvi) - amiodaron, bepridil, flekainid, propafenon, ili kinidin (primjenjuju se u liječenju srčanih poremećaja) - metoprolol (primjenjuje se u liječenju zatajenja srca) - alfuzosin i sildenafil (kada se primjenjuju u liječenju rijetkog poremećaja krvnih žila koji se karakterizira povišenim tlakom u plućnoj arteriji) - kolhicin (kada se primjenjuje u liječenju naglih pogoršanja gihta u bolesnika s bolešću bubrega ili jetre).
English: Dosing of Aptivus, co-administered with low dose ritonavir, with antacids should be separated by at least a two hours time interval.
Croatian: Doziranje Aptivusa s niskom dozom ritonavira i antacida potrebno je odvojiti u minimalnom intervalu od dva sata.
English: Saquinavir Cmax ↓ 70% Saquinavir AUC ↓ 76% Saquinavir Cmin ↓ 82%
Croatian: Sakvinavir Cmax ↓ 70% Sakvinavir AUC ↓ 76% Sakvinavir Cmin ↓ 82%
English: Alternative or additional contraceptive measures are to be used when oestrogen based oral contraceptives are co-administered with Aptivus co-administered with low dose ritonavir (see section 4.5).
Croatian: Potrebno je primjenjivati alternativne ili dodatne kontraceptivne mjere kad se oralni kontraceptivi na bazi estrogena primjenjuju istodobno s Aptivusom i ritonavirom (vidjeti dio 4.5).
English: You should therefore carefully read the Package Leaflets of ritonavir and your other antiretroviral medicines.
Croatian: Prema tome, pažljivo pročitajte upute koje se prilažu uz ritonavir i druge antiretrovirusne lijekove koje primjenjujete.
English: Dosage increase and long-term use of meperidine with Aptivus, coadministered with low dose ritonavir, are not recommended due to the increased concentrations of the metabolite normeperidine which has both analgesic activity and CNS stimulant activity (e.g. seizures).
Croatian: U bolesnika liječenih Aptivusom, uz nisku dozu ritonavira ne preporučuje se istodobna dugotrajna primjena meperidina ili povišenje doza meperidina zbog povećanih koncentracija metabolita normeperidina koji ima analgetski učinak i stimulira središnji živčani sustav (npr. epileptični napadaji).
English: Overall population FAS
Croatian: Ukupna populacija Svi ispitanici PP
English: Muscle disorders
Croatian: Poremećaji mišića
English: Do not take products containing St John's wort (a herbal remedy for depression).
Croatian: Ne uzimajte proizvode koji sadrže gospinu travu (biljni lijek protiv depresije), jer ona može spriječiti ispravno djelovanje Aptivusa.
English: Depending on your liver function you may have to delay or stop Aptivus treatment - if you are currently taking products containing: - rifampicin (used to treat tuberculosis) - cisapride (used to treat stomach problems) - pimozide or sertindole (used to treat schizophrenia) - quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder) - lurasidone (used to treat schizophrenia) - triazolam or oral midazolam (taken by mouth).
Croatian: Vaše jetre, možda ćete morati odgoditi ili prekinuti liječenje Aptivusom - ako trenutno uzimate lijekove koji sadrže: - rifampicin (primjenjuje se u liječenju tuberkuloze) - cisaprid (primjenjuje se u liječenju želučanih problema) - pimozid ili sertindol (primjenjuju se u liječenju shizofrenije) - kvetiapin (primjenjuje se u liječenju shizofrenije, bipolarnog poremećaja i velikog depresivnog poremećaja) - lurasidon (primjenjuje se u liječenju shizofrenije) - triazolam ili oralni midazolam (uzimaju se oralno).
English: Narcotic analgesics Methadone 5 mg QD Methadone Cmax ↓ 55% Methadone AUC ↓ 53% Methadone Cmin ↓ 50%
Croatian: Metadon Cmax ↓ 55% Metadon AUC ↓ 53% Metadon Cmin ↓ 50%
English: All patients * Includes patients who did not receive ENF and those who were previously treated with and continued ENF ** Mutations in HIV protease at positions L10V, I13V, K20M/R/V, L33F, E35G, M36I, K43T, M46L, I47V, I54A/M/V, 58E, H69K, T74P, V82L/T, N83D or I84V ENF Enfuvirtide; TPV/r Tipranavir with ritonavir
Croatian: * Uključuje bolesnike koji nisu primali ENF i one koji su prethodno primali ENF i to su liječenje nastavili i u pokusu ** Mutacije HIV proteaze na pozicijama L10V, I13V, K20M/R/V, L33F, E35G, M36I, K43T, M46L, I47V, I54A/M/V, 58E, H69K, T74P, V82L/T, N83D, ili I84V ENF enfuvirtid; TPV/r tipranavir s ritonavirom
English: If you miss a dose of Aptivus or ritonavir by more than 5 hours, wait and then take the next dose of Aptivus and ritonavir at the regularly scheduled time.
Croatian: Ako propustite dozu Aptivusa ili ritonavira za više od 5 sati, pričekajte i zatim uzmite sljedeću dozu Aptivusa i ritonavira u redovno vrijeme, prema režimu doziranja.
English: Stavudine
Croatian: Stavudin
English: In such cases no dosage adjustment of zidovudine can be recommended (see section
Croatian: U takvom slučaju nije potrebno podešavati dozu zidovudina (vidjeti dio 4.4).
English: Propyl gallate
Croatian: Lanzoprazol Pantoprazol
English: If your child misses a dose of Aptivus or ritonavir by more than 5 hours, wait and then give the next dose of Aptivus and ritonavir at the regularly scheduled time.
Croatian: Ako Vaše dijete propusti dozu Aptivusa ili ritonavira za više od 5 sati, neka pričeka i zatim uzme sljedeću dozu Aptivusa i ritonavira u redovno vrijeme, prema režimu doziranja.
English: No data are currently available on interactions of tipranavir, coadministered with low dose ritonavir, with protease inhibitors other than those listed above.
Croatian: Trenutno nisu dostupni podaci o interakcijama tipranavira s niskom dozom ritonavira, s drugim inhibitorima proteaze osim gore navedenih.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each soft capsule contains 250 mg tipranavir
Croatian: NAVOĐENJE DJELATNE(IH) TVARI Jedna meka kapsula sadrži 250 mg tipranavira
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with dihydroergotamine, ergonovine, ergotamine or methylergonovine is contraindicated due to potential serious and/or life threatening events (see section 4.3)
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i dihidroergotamina, ergonovina, ergotamina, ili metilergonovina je kontraindicirana zbog potencijalnih teških i/ili fatalnih događaja (vidjeti dio 4.3)
English: Absorption of tipranavir, co-administered with low dose ritonavir, is reduced in the presence of antacids (see section 4.5).
Croatian: Apsorpcija tipranavira s niskom dozom ritonavira je smanjena u prisustvu antacida (vidjeti dio 4.5).
English: It has not been shown that tipranavir is superior to these boosted comparator protease inhibitors in patients harbouring strains susceptible to these protease inhibitors.
Croatian: Nije pokazana superiornost tipranavira spram kontrolnog tretmana u bolesnika koji su imali virusne sojeve osjetljive na kontrolne inhibitore proteaze.
English: Therefore Aptivus, co-administered with low dose ritonavir, should be given with food.
Croatian: Stoga se Aptivus s niskom dozom ritonavira uzima zajedno s hranom.
English: Steady-state tipranavir/r Midazolam Cmax ↑ 3.7 fold Midazolam AUC ↑ 9.8 fold
Croatian: Tipranavir/r u stanju ravnoteže Midazolam Cmax ↑ 3,7 puta Midazolam AUC ↑ 9,8 puta
English: TPV/r 500/100 mg, TPV/r 750/200 mg) represented extremes of hepatic enzyme induction and inhibition and bracketed the recommended dosage of Aptivus/r.
Croatian: Ipak, rezultati mnogih od ovih ispitivanja o interakcijama mogu se ekstrapolirati u preporučeno doziranje, s obzirom da su primijenjene doze (npr. TPV/r 500/100 mg, TPV/r 750/200 mg) predstavljale ekstreme indukcije i inhibicije jetrenih enzima, te su obuhvatile preporučene doze Aptivusa/r.
English: Aptivus must be administered with low dose ritonavir to ensure its therapeutic effect (see section 4.2).
Croatian: Aptivus se, u svrhu osiguranja terapijskog učinka, mora primjenjivati s niskom dozom ritonavira (vidjeti dio 4.2).
English: Co-administration of Aptivus, coadministered with low dose ritonavir, and rosuvastatin should be initiated with the lowest dose (5 mg/day) of rosuvastatin, titrated to treatment response, and accompanied with careful clinical monitoring for rosuvastatin associated symptoms as described in the label of rosuvastatin.
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i rosuvastatina započinje najnižom dozom (5 mg/dan) rosuvastatina, titriranom do terapijskog odgovora, uz pažljivo kliničko praćenje radi nuspojava rosuvastatina.
English: Abacavir and zidovudine
Croatian: Abakavir i zidovudin
English: P-gp activity is significantly inhibited after the first dose,
Croatian: Aktivnost P-gp-a je značajno inhibirana nakon prve doze, ali je u stanju dinamičke ravnoteže uočena blaga indukcija.
English: Aptivus oral solution contains vitamin E. Your child should not take any additional vitamin E supplements.
Croatian: Vaše dijete ne smije dodatno uzimati dodatke koji sadrže vitamin E.
English: Do not refrigerate or freeze After first opening of the bottle, the product can be used for 60 days.
Croatian: Nakon prvog otvaranja boce, lijek se može koristiti 60 dana.
English: Mean decrease in viral load from baseline to week 48, according to tipranavir baseline mutation score and enfuvirtide use in RESIST patients
Croatian: Prosječno smanjenje virusnog opterećenja od početka do 48. tjedna, u odnosu na „mutacijski skor“ i primjenu enfuvirtida u bolesnika u RESIST
English: Posology The recommended dose for children (age 2 to 12 years) is 375 mg/m2 Aptivus co-administered with
Croatian: Preporučena doza za djecu (u dobi 2 do 12 godina) je 375 mg/m2 Aptivusa sa 150 mg/m2 ritonavira,
English: Induction of CYP 2C19 by tipranavir/r
Croatian: Indukcija CYP 2C19 putem tipranavira/r
English: Rash consists of one or more of the preferred terms of rash, drug eruption, rash macular, rash papular, erythema, rash maculo-papular, rash pruritic, and urticaria
Croatian: Jedan ili više preferiranih termina: osip, medikamentozna erupcija, makularni osip, papularni osip, eritem, makulopapularni osip, pruritički osip ili urtikarija
English: In the tipranavir and comparator arms median baseline CD4 cell counts were 158 and 166 cells/mm
Croatian: Medijan početnog broja CD4 stanica u ispitivanoj skupini iznosio je 158 stanica/mm
English: Amber glass bottle, with two-piece plastic child-resistant closure (outer shell high density polyethylene (HDPE), inner shell polypropylene resin with a foamed laminated polyethylene liner.. Each pack contains 1 bottle of 95 ml oral solution and is supplied with a clear polypropylene 5 ml oral syringe, HDPE syringe tip cap and clear LDPE bottle-syringe adapter.
Croatian: Svako pakiranje sadrži 1 bocu sa 95 ml oralne otopine, s priloženom prozirnom polipropilenskom oralnom štrcaljkom od 5 ml, HDPE zatvaračem za štrcaljku i prozirnim nastavkom za bocu i štrcaljku od polietilena niske gustoće (LDPE).
English: Each Aptivus capsule contains 250 mg of the active substance tipranavir.
Croatian: Jedna Aptivus kapsula sadrži 250 mg djelatne tvari, tipranavira.
English: Recommendations concerning co-administration
Croatian: Preporuke o istodobnoj primjeni
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with flecainide, propafenone or metoprolol is contraindicated (see section 4.3)
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i flekainida, propafenona, ili metoprolola je kontraindicirana (vidjeti dio 4.3)
English: Antimalarial Halofantrine Lumefantrine No interaction study performed
Croatian: Lumefantrin Nije provedeno ispitivanje interakcija
English: In pre- and post-natal development studies with tipranavir in rats, growth inhibition of pups was observed at maternally toxic doses approximating 0.8-fold human exposure.
Croatian: U ispitivanjima pre- i postnatalnog razvoja u štakora, sistemska izloženost toksična za majku bila je oko 20% niža od sistemske izloženosti u ljudi pri preporučenim kliničkim dozama i rezultirala je inhibicijom rasta mladunaca.
English: The concomitant use of Aptivus, coadministered with low dose ritonavir, with abacavir is not recommended unless there are no other available NRTIs suitable for patient management.
Croatian: Istodobna primjena Aptivusa, s niskom dozom ritonavira, i abakavira se ne preporučuje, osim ako on nije jedini NRTI prikladan za zbrinjavanje bolesnika.
English: The combined use of Aptivus, coadministered with low dose ritonavir, with either omeprazole or esomeprazole is not recommended (see section 4.4).
Croatian: Kombinirana primjena Aptivusa s niskom dozom ritonavira i omeprazola ili esomeprazola se ne preporučuje (vidjeti dio 4.4).
English: Compared to the capsules, tipranavir exposure is higher when administering the same dose as oral solution.
Croatian: U usporedbi s kapsulama, ista doza u obliku oralne otopine rezultira većom izloženošću tipranaviru.
English: If the co-administration with bupropion is judged unavoidable, this should be done under close clinical monitoring for bupropion efficacy, without exceeding the recommended dosage, despite the observed induction.
Croatian: Sniženje vrijednosti bupropiona u plazmi javlja se vjerojatno zbog indukcije aktivnosti CYP2B6 i UGT ritonavirom praćenje radi učinkovitosti bupropiona, bez prekoračivanja preporučenog doziranja, usprkos primijećenoj indukciji.
English: Inhibition of CYP 3A4 and CYP 2D6 by tipranavir/r
Croatian: Inhibicija CYP 3A4 i CYP 2D6 putem tipranavira/r
English: Digoxin 0.25 mg QD po
Croatian: Digoksin 0,25 mg QD p.o.
English: Based on theoretical considerations, The concomitant use of Aptivus,
Croatian: Temeljem teoretskih razmatranja, istodobna primjena tipranavira s
English: Examples include: - rifabutin and clarithromycin (antibiotics) - theophylline (used to treat asthma) - desipramine, trazodone and bupropion (used to treat depression; bupropion is also used for smoking cessation) - midazolam (when given by injection); midazolam is a sedative used to treat anxiety and to help you sleep - rosuvastatin or pravastatin (used to lower blood cholesterol) - colchicine (used to treat gout flares with normal kidney and liver function).
Croatian: Primjeri uključuju: - rifabutin i klaritromicin (antibiotici) - teofilin (primjenjuje se u liječenju astme) - desipramin, trazodon i bupropion (primjenjuju se u liječenju depresije: bupropion se također primjenjuje u prekidu pušenja) - midazolam (kada se daje injekcijskim putem); midazolam je sedativ koji se primjenjuje u liječenju anksioznosti i kao pomoć u uspavljivanju - rosuvastatin ili pravastatin (primjenjuju se u snižavanju kolesterola u krvi) - kolhicin (koji se primjenjuje u liječenju naglih pogoršanja gihta uz urednu funkciju bubrega i jetre).