FrancophonIA/ELRC3.0 huggingface dataset:
English: Ear and labyrinth disorders Common
Slovenian: Ušesne bolezni, vključno z motnjami labirinta pogosti vrtoglavica
English: • tighten the needle and cap with a gentle clockwise twist.
Slovenian: ● iglo s pokrovom pritrdite z rahlim zavojem v smeri urinega kazalca.
English: Psychiatric disorders Common
Slovenian: Očesne bolezni pogosti konjunktivitis
English: These patients did not experience any adverse reactions that were not seen with the recommended dose.
Slovenian: Posvetujte se tudi, če opazite neželene učinke, ki niso navedeni v tem navodilu.
English: Please contact your doctor if this occurs.
Slovenian: Če se pojavijo pri vas, prosimo, obvestite svojega zdravnika.
English: NAME OF THE MEDICINAL PRODUCT Fuzeon 90 mg/ml powder and solvent for solution for injection Enfuvirtide
Slovenian: Navodilo za uporabo Fuzeon 90 mg/ml prašek in vehikel za raztopino za injiciranje enfuvirtid
English: • inflamed sinuses
Slovenian: • zamašen nos,
English: C.
Slovenian: HIV.
English: Denominator for non-switch patients: N=112.
Slovenian: n = 112.
English: PHARMACEUTICAL FORM AND CONTENTS Powder for solution for injection 60 vials with powder for solution for injection
Slovenian: 60 vial s praškom za raztopino za injiciranje
English: You should check with your doctor, pharmacist or nurse if you are not sure.
Slovenian: posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Pruritus f
Slovenian: PRILOGA I
English: Always use this medicine exactly as your doctor or pharmacist has told you.
Slovenian: Kako jemati zdravilo Fuzeon Pri uporabi tega zdravila natančno upoštevajte navodila zdravnika ali farmacevta.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON
Slovenian: PODATKI NA ZUNANJI OVOJNINI ZUNANJA OVOJNINA
English: NAME OF THE MEDICINAL PRODUCT Fuzeon 90 mg/ml powder and solvent for solution for injection
Slovenian: Fuzeon 90 mg/ml prašek in vehikel za raztopino za injiciranje
English: b. Tabulated list of adverse reactions
Slovenian: b. Neželeni učinki, prikazani v preglednici
English: Safety Tips
Slovenian: Navodila za varno uporabo
English: These measures will help to protect the environment.
Slovenian: Taki ukrepi pomagajo varovati okolje.
English: Survival (months)
Slovenian: Preživetje (meseci)
English: Ask your doctor for advice.
Slovenian: Prosite zdravnika za nasvet.
English: Date of first authorisation: 12 November 1996 Date of latest renewal: 20 November 2006
Slovenian: Datum prve odobritve: 12. november 1996 Datum zadnjega podaljšanja: 20. november 2006
English: Toxicity was predictable and reversible.
Slovenian: Toksičnost je bila predvidljiva in reverzibilna.
English: Study 396
Slovenian: Študija 396
English: Just take the next dose at the scheduled time.
Slovenian: Preprosto vzemite naslednji odmerek ob predvidenem času.
English: Tell your doctor if any of these applies to you.
Slovenian: Zdravniku morate povedati, če kaj od tega velja za vas.
English: The clinical significance of this finding is unclear.
Slovenian: Klinični pomen tega izsledka ni jasen.
English: Study 065
Slovenian: Študija 065
English: 3 years.
Slovenian: 3 leta
English: • if you are pregnant or plan to become pregnant.
Slovenian: • če ste noseči ali nameravate zanositi.
English: None known.
Slovenian: Niso znane.
English: If you feel tired or weak, do not drive or use machines.
Slovenian: Če se počutite utrujeno ali slabotno, ne upravljajte vozil in strojev.
English: Further dilution is required.
Slovenian: Potrebno je še dodatno redčenje.
English: Currently available data are described in sections 5.1 and 5.2 but no recommendation on a posology can be made.
Slovenian: Trenutno razpoložljivi podatki so opisani v poglavjih 5.1 in 5.2, vendar priporočil o odmerjanju ni mogoče dati.
English: This increase is considered unlikely to be of clinical relevance.
Slovenian: To povečanje po vsej verjetnosti nima kliničnega pomena.
English: You should use an effective method of contraception.
Slovenian: Uporabljati morate učinkovito kontracepcijsko zaščito.
English: The treatment may vary, depending on the results of your regular blood tests.
Slovenian: Zdravljenje je lahko tudi drugačno, odvisno od izvidov vaših rednih krvnih preiskav.
English: It may harm a baby conceived before, during or soon after treatment.
Slovenian: Škoduje lahko otroku, spočetemu pred zdravljenjem, med zdravljenjem ali kmalu po njem.
English: Table 2 Study results Study GOG-0179
Slovenian: Rezultati študije GOG-0179
English: This medicine is for single use only.
Slovenian: Zdravilo je namenjeno samo za enkratno uporabo.
English: After opening, the product should be used immediately.
Slovenian: Po odprtju je treba zdravilo uporabiti takoj.
English: Total exposure (AUC) increases approximately proportionally with dose.
Slovenian: Celotna izpostavljenost (AUC) se povečuje približno sorazmerno odmerku.
English: The median time to response in clinical studies was 7.6-11.6 weeks.
Slovenian: Mediana časa do odziva je v kliničnih študijah znašala od 7,6 do 11,6 tedna.
English: Reactions have been mild and have not generally required specific therapy.
Slovenian: Reakcije so bile blage, specifično zdravljenje pa običajno ni bilo potrebno.
English: It may harm them, even if their symptoms seem to be the same as yours.
Slovenian: Njim bi lahko celo škodovalo, čeprav imajo znake bolezni, podobne vašim.
English: No overall differences in effectiveness were observed between patients aged over 65 years and younger adult patients.
Slovenian: V celoti niso ugotovili razlik v učinkovitosti med bolniki, starejšimi od 65 let, in mlajšimi odraslimi bolniki.
English: Do not use this medicine after the expiry date which is stated on the carton.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli.
English: Frequencies are defined as: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data).
Slovenian: Pogostnosti so opredeljene takole: zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10), občasni (≥1/1.000 do <1/100), redki (≥1/10.000 do <1/1.000), zelo redki (<1/10.000) in pogostnost neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: Male patients who wish to father a child should ask their doctor for family planning advice or treatment.
Slovenian: Bolniki, ki bi želeli zaploditi otroka, se morajo z zdravnikom posvetovati glede načrtovanja družine oziroma zdravljenja.
English: • if you are allergic to topotecan or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični na topotekan ali katero koli sestavino tega zdravila (navedeno v poglavju 6),
English: The product should be used immediately after reconstitution as it contains no antibacterial preservative.
Slovenian: Pripravek je potrebno uporabiti takoj po rekonstituciji, saj ne vsebuje protibakterijskih konzervansov.
English: Mean half-life increased from 1.9 hours to 4.9 hours.
Slovenian: Srednja razpolovna doba se je z 1,9 ure podaljšala na 4,9 ure.
English: • Signs of infections: Hycamtin may reduce the number of white blood cells and lower your resistance to infection.
Slovenian: • znaki okužbe: zdravilo Hycamtin lahko zmanjša število belih krvnih celic in vašo odpornost proti okužbam.
English: Store in a refrigerator (2ºC - 8ºC).
Slovenian: Shranjujte v hladilniku (2 °C - 8 °C).
English: Overall, 87 complete and partial responses were observed, with 13 of these occurring during cycles 5 and 6 and 3 occurring thereafter.
Slovenian: Skupno so zasledili 87 popolnih ali delnih odzivov, od katerih se jih je 13 pojavilo v 5. ali 6. ciklusu, 3 pa v poznejših ciklusih.
English: No studies of the effects on the ability to drive and use machines have been performed.
Slovenian: Študij o vplivu na sposobnost vožnje in upravljanja strojev niso izvedli.
English: 16 INFORMATION IN BRAILLE
Slovenian: 16 PODATKI V BRAILLOVI PISAVI
English: Volume of distribution was slightly decreased and thus half-life only increased by 14%.
Slovenian: Volumen porazdelitve je bil malo manjši, zato se je razpolovna doba podaljšala le za 14 %.
English: Tell your doctor if you are taking, have recently taken, or might take any other medicines, including any herbal products or medicines obtained without a prescription.
Slovenian: Obvestite zdravnika, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo, kar velja tudi za vse zeliščne izdelke in za zdravila, ki ste jih dobili brez recepta.
English: 10 capsules
Slovenian: 10 kapsul
English: Initial dose
Slovenian: Začetni odmerek
English: 90429 Nuremberg Germany
Slovenian: 90429 Nürnberg Nemčija
English: Each blister contains 10 capsules.
Slovenian: Vsak pretisni omot vsebuje 10 kapsul.
English: Further management should be as clinically indicated or as recommended by the national poisons centre, where available.
Slovenian: Nadaljnja obravnava naj poteka v skladu s kliničnimi indikacijami oziroma priporočili nacionalnega centra za zastrupitve, kjer so na voljo.
English: This can be serious.
Slovenian: • driska: ta je lahko resna.
English: Hycamtin is not recommended for pregnant women.
Slovenian: Zdravilo Hycamtin ni priporočljivo za nosečnice.
English: Push out the capsule: gently push one end of the capsule through the foil layer.
Slovenian: Potisnite kapsulo ven: previdno potisnite en konec kapsule skozi plast folije.
English: In these studies there were no apparent differences in the pharmacokinetics of topotecan among children, adolescents and young adult patients with solid tumours or leukaemia, but data are too limited to draw definite conclusions.
Slovenian: V teh študijah ni bilo zaznati očitnih razlik v farmakokinetiki topotekana pri otrocih, mladostnikih in mlajših odraslih s solidnim tumorjem ali levkemijo, vendar pa je podatkov premalo, da bi lahko podali definitivne zaključke.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user.
Slovenian: Če zdravila ne uporabi takoj, je za čas in pogoje shranjevanja pred uporabo zdravila odgovoren uporabnik sam.
English: Talk to your doctor for advice on how to minimise the risk of bleeding.
Slovenian: Posvetujte se z zdravnikom, kako lahko zmanjšate tveganje za pojav krvavitev;
English: • The active substance is topotecan.
Slovenian: • Učinkovina je topotekan.
English: This treatment schedule is repeated every 21 days for six courses or until progressive disease.
Slovenian: Takšna shema zdravljenja se ponavlja vsakih 21 dni, šest ciklusov ali dokler bolezen ne napreduje.
English: Patients with Grade 2 diarrhoea may need to follow the same dose modification guidelines.
Slovenian: Morda bo tudi pri bolnikih z drisko stopnje 2 treba slediti enakim navodilom za prilagoditev odmerka.
English: In some cases you may need a blood transfusion.
Slovenian: V nekaterih primerih je v primeru anemije potrebna transfuzija krvi;
English: Adverse reactions are listed below, by system organ class and absolute frequency (all reported events).
Slovenian: Spodaj so navedeni neželeni učinki, razvrščeni po organskih sistemih in absolutni pogostnosti (vsi dogodki, o katerih so poročali).
English: The carcinogenic potential of topotecan has not been studied.
Slovenian: Kancerogeni potencial topotekana ni raziskan.
English: Area under the curve increased approximately in proportion to the increase in dose.
Slovenian: Površina pod krivuljo je naraščala približno sorazmerno z velikostjo odmerka.
English: Of the patients who received more than 6 cycles of therapy, 91% completed the study as planned or were treated until disease progression, with only 3% withdrawn for adverse events.
Slovenian: Od bolnic, ki so prejele več kot 6 ciklusov zdravljenja, jih je 91 % dokončalo študijo, kot je bilo predvideno, ali pa so jih zdravili, dokler bolezen ni napredovala.
English: Paediatric population The safety and effectiveness of oral topotecan in paediatric patients have not been established.
Slovenian: Pediatrična populacija Varnost in učinkovitost peroralnega topotekana pri pediatričnih bolnikih nista ugotovljeni.
English: Camberley, Surrey GU16 7SR United Kingdom
Slovenian: Camberley, Surrey GU16 7SR Velika Britanija
English: • if your blood cell counts are too low.
Slovenian: • če imate prenizko število krvnih celic.
English: • Staff should be trained to reconstitute the medicinal product.
Slovenian: • Osebje mora biti ustrezno izurjeno za rekonstitucijo zdravila.
English: Patients with creatinine clearance >60 ml/min have been included in efficacy/safety studies of topotecan.
Slovenian: Bolniki z očistkom kreatinina >60 ml/min so bili vključeni v študijo o učinkovitosti/varnosti topotekana.
English: • if you have any kidney or liver problems.
Slovenian: • če imate kakršne koli težave z ledvicami ali jetri.
English: If you have more than 3 episodes of diarrhoea per day you should contact your doctor immediately.
Slovenian: Če imate drisko več kot 3-krat na dan, se morate nemudoma posvetovati z zdravnikom.
English: Before you are given this medicine your doctor needs to know:
Slovenian: Preden boste prejeli to zdravilo, morate zdravniku povedati:
English: This can even be life threatening.
Slovenian: To je lahko tudi smrtno nevarno.
English: The pharmacokinetics of topotecan given as a 30-minute infusion for 5 days were evaluated in two studies.
Slovenian: Farmakokinetiko topotekana, ki so ga dajali v obliki 30-minutne infuzije 5 dni, so ovrednotili v dveh študijah.
English: Taking out a capsule These capsules come in special packaging to prevent children removing them.
Slovenian: Kako vzamete kapsulo iz pakiranja Kapsule so zaprte v posebnem pakiranju, ki preprečuje, da bi jih iz njega vzeli otroci.
English: Your doctor will tell you whether this is the case, based on the results of your last blood test.
Slovenian: To vam bo povedal zdravnik na podlagi izvida vaše zadnje preiskave krvi.
English: In this analysis, creatinine clearance was calculated using the Cockcroft-Gault method.
Slovenian: V tej analizi so očistek kreatinina izračunali s Cockcroft-Gaultovo enačbo.
English: • Yellow skin.
Slovenian: rumena koža.
English: There may be a higher than usual chance of you getting side effects if you are also being treated with cyclosporin A. You will be monitored closely if you are taking both these medicines.
Slovenian: Verjetnost neželenih učinkov je lahko večja kot sicer, če dobivate tudi zdravilo ciklosporin A. Med uporabo teh dveh zdravil vas bodo natančno nadzirali.
English: • your body size (surface area measured in square metres)
Slovenian: • velikost vašega telesa (telesno površino, izraženo v kvadratnih metrih),
English: Standard oncology practice for the management of neutropenia is either to administer topotecan with other medicinal products (e.g. G-CSF) or to reduce the dose to maintain neutrophil counts.
Slovenian: Standardna onkološka praksa za obvladovanje nevtropenije je bodisi uporaba topotekana z drugimi zdravili (npr. G-CSF) bodisi zmanjšanje odmerka za ohranitev števila nevtrofilcev.
English: The frequency of some side effects is not known (events from spontaneous reports and the frequency cannot be estimated from the available data):
Slovenian: Za nekatere neželene učinke pogostnost ni znana (podatki o njih izhajajo iz spontanih poročil, tako da njihove pogostnosti ni mogoče ugotoviti iz razpoložljivih podatkov).
English: All cases were irrespective of associated causality.
Slovenian: Vsi primeri so bili zabeleženi ne glede na vzročno povezanost z zdravilom.
English: • the results of blood tests carried out before treatment
Slovenian: • izvide krvnih preiskav, opravljenih pred začetkom zdravljenja,
English: Your doctor will decide with you whether Hycamtin therapy is better than further treatment with your initial chemotherapy.
Slovenian: Zdravnik bo skupaj z vami presodil, ali je zdravljenje z zdravilom Hycamtin za vas boljše kot nadaljevanje zdravljenja s predhodno obliko kemoterapije.
English: A doctor or a nurse will give you the medicine as an infusion into a vein in hospital.
Slovenian: Zdravilo vam bo dal zdravnik ali medicinska sestra v obliki infuzije v žilo v bolnišnici.
English: Hycamtin capsules may be taken with or without food (see section 5.2).
Slovenian: Kapsule zdravila Hycamtin lahko vzame s hrano ali brez nje (glejte poglavje 5.2).
English: For storage conditions after reconstitution and dilution of the medicinal product, see section 6.3.
Slovenian: Za pogoje shranjevanja po rekonstituciji in redčenju zdravila glejte poglavje 6.3.
English: The normal procedures for proper handling and disposal of anticancer medicinal products should be adopted, namely:
Slovenian: Upoštevati morate običajne postopke za ustrezno ravnanje z zdravili proti raku in njihovo odstranjevanje, in sicer:
English: Korean patients with renal impairment had generally higher exposure than non-Asian patients with the same degree of renal impairment.
Slovenian: Pri korejskih bolnikih z ledvično okvaro je bila izpostavljenost na splošno večja kot pri neazijskih bolnikih z enako stopnjo ledvične okvare.
English: The overall incidence of drug-related diarrhoea was 22%, including 4% with Grade 3 and 0.4% with Grade 4.
Slovenian: Skupna incidenca z zdravilom povezane driske je bila 22 %, vključno s 4 % 3. stopnje in 0,4 % 4. stopnje.
English: Do not try to become pregnant until a doctor advises you it is safe to do so.
Slovenian: Ne poskušajte zanositi, dokler vam zdravnik ne pove, da je to varno.
English: If well tolerated, treatment may continue until disease progression (see sections 4.8 and 5.1).
Slovenian: Če bolniki zdravljenje dobro prenašajo, je mogoče z njim nadaljevati, dokler bolezen ne napreduje (glejte poglavji 4.8 in 5.1).
English: Anti-tumour activity was demonstrated primarily in patients with neuroblastoma.
Slovenian: Protitumorsko delovanje je bilo dokazano predvsem pri bolnikih z nevroblastomom.
English: Topotecan also had a high volume of distribution, about 132 l (SD 57), and a relatively short half-life of 2-3 hours.
Slovenian: Topotekan ima tudi velik volumen porazdelitve, približno 132 l (s standardno deviacijo 57), in sorazmerno kratko razpolovno dobo, 2-3 ure.
English: If your partner becomes pregnant during your treatment, tell your doctor immediately.
Slovenian: Če med zdravljenjem zanosi vaša partnerka, o tem takoj obvestite zdravnika.
English: The usual dose
Slovenian: Običajni odmerek
English: Separate one capsule: tear along the perforated lines to separate one capsule “pocket” from the strip.
Slovenian: Ločite eno kapsulo: odtrgajte vzdolž perforiranih črt, da boste en "žep" s kapsulo ločili od traku.
English: Vials 3 years.
Slovenian: Viale 3 leta
English: • advanced cervical cancer if surgery or radiotherapy treatment is not possible.
Slovenian: • napredovalega raka materničnega vratu, če zdravljenje z operacijo ali obsevanjem ni možno.
English: Drug-related diarrhoea was more frequent in patients 65 years of age (28%) compared to those less than 65 years of age (19%).
Slovenian: Z zdravilom povezana driska je bila pogostejša med bolniki, starimi 65 let (28 %), kot med bolniki, mlajšimi od 65 let (19 %).
English: Instructions on how to reconstitute, store and dispose of Hycamtin
Slovenian: Navodila za rekonstitucijo, shranjevanje in odstranjevanje zdravila Hycamtin
English: Hycamtin contains ethanol This medicine contains small amounts of ethanol (alcohol).
Slovenian: Zdravilo Hycamtin vsebuje alkohol Zdravilo vsebuje majhno količino etanola (alkohola).
English: This pattern of treatment will normally be repeated every 3 weeks.
Slovenian: Tak režim zdravljenja boste praviloma prejemali vsake 3 tedne.
English: Justification for not including Braille accepted
Slovenian: Sprejeta je utemeljitev, da Braillova pisava ni potrebna
English: • the disease being treated.
Slovenian: • bolezen, zaradi katere se zdravite.
English: A. MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALCI, ODGOVORNI ZA SPROŠČANJE SERIJ
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu/.
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/.
English: This should be taken into account when prescribing HYCAMTIN, e.g. if patients at increased risk of tumour bleeds are considered for therapy.
Slovenian: To je treba upoštevati pri predpisovanju zdravila Hycamtin, npr. pri odločanju za zdravljenje bolnikov, pri katerih obstaja večje tveganje za krvavitve tumorja.
English: Median survival was 30.3 weeks (95% CI: 27.6, 33.4).
Slovenian: Mediana časa preživetja je bila 30,3 tedna (95-odstotni IZ: 27,6, 33,4).
English: Your dose of Hycamtin may need to be adjusted.
Slovenian: Odmerek zdravila Hycamtin bo morda treba prilagoditi.
English: • Mild pain and inflammation at the site of injection.
Slovenian: • blaga bolečina in vnetje na mestu injiciranja zdravila;
English: Limited data in Korean patients with creatinine clearance less than 50 ml/min suggest a further lowering of dose may be required (see section 5.2).
Slovenian: Omejeni podatki, ki so na voljo za korejske bolnike z očistkom kreatinina <50 ml/min, so pokazali, da bi bilo lahko potrebno nadaljnje zmanjšanje odmerka (glejte poglavje 5.2).
English: Clinical guidelines describing the aggressive management of CTID include specific recommendations on patient communication and awareness, recognition of early warning signs, use of anti-diarrhoeals and antibiotics, changes in fluid intake and diet, and need for hospitalisation (see sections 4.2 and 4.8).
Slovenian: Klinične smernice za odločno obvladovanje driske zaradi zdravil proti raku vključujejo specifična priporočila za informiranje in ozaveščanje bolnika, prepoznavanje zgodnjih opozorilnih znakov, uporabo antidiaroikov in antibiotikov, spremembe v uživanju tekočin in prehrani ter sprejem v bolnišnico (glejte poglavji 4.2 in 4.8).
English: Topotecan must be reconstituted and further diluted before use (see section 6.6).
Slovenian: Pred uporabo je treba topotekan rekonstituirati in nato še nadalje razredčiti (glejte poglavje 6.6).
English: A cross-study analysis in 217 patients with advanced solid tumours indicated that gender did not affect the pharmacokinetics of HYCAMTIN capsules to a clinically relevant extent.
Slovenian: Analiza navzkrižne študije 217 bolnikov z napredovalimi čvrstimi tumorji je pokazala, da spol ne vpliva klinično pomembno na farmakokinetiko zdravila HYCAMTIN v kapsulah.
English: The dose (and number of capsules) of Hycamtin you are given will be worked out by your doctor, based on:
Slovenian: Odmerek (in število kapsul) zdravila Hycamtin, ki ga boste dobili, bo zdravnik določil glede na:
English: As would be expected, patients with poor performance status (PS >1) have a lower response rate and an increased incidence of complications such as fever, infection and sepsis (see section 4.8).
Slovenian: Kot je mogoče pričakovati, se bolniki s slabšo telesno zmogljivostjo (performance status, PS >1) slabše odzivajo na zdravilo, večja pa je tudi pogostnost zapletov, kot so zvišana telesna temperatura, okužbe in sepsa (glejte poglavje 4.8).
English: In addition, 5% of all patients treated (1% of courses) developed sepsis (see section 4.4).
Slovenian: Poleg tega je pri 5 % vseh zdravljenih bolnikov (v 1 % ciklusov zdravljenja) prišlo do sepse (glejte poglavje 4.4).
English: The powder needs to be reconstituted and diluted before infusion.
Slovenian: Pred infuzijo je treba prašek rekonstituirati in razredčiti.
English: Other than hydrolysis, topotecan is cleared predominantly renally, with a minor component metabolised to the N-desmethyl metabolite (SB-209780) identified in plasma, urine and faeces.
Slovenian: Poleg hidrolize se topotekan odstrani predvsem skozi ledvice, manjši del pa se ga presnovi v N-desmetilni presnovek (SB-209780), ki se pojavi v plazmi, urinu in blatu.
English: In a population study, a number of factors including age, weight and ascites had no significant effect on clearance of total topotecan (active and inactive form).
Slovenian: V populacijski študiji številni dejavniki, vključno s starostjo, telesno maso in ascitesom, niso pomembno vplivali na očistek celotnega topotekana (aktivne in neaktivne oblike).