FrancophonIA/ELRC3.0 huggingface dataset:
English: p-value (Log-Rank test, stratified1) 3 year event-free rate2 [95% CI]
Croatian: HR [95% CI] p-vrijednost (log-rang test, stratificiran1)
English: GD100.
Croatian: RMP-a.
English: Insomnia
Croatian: • nesanica
English: No patients in the group treated with Perjeta plus trastuzumab and FEC followed by Perjeta plus trastuzumab and docetaxel experienced symptomatic LVD.
Croatian: Simptomatska disfunkcija lijeve klijetke nije nastupila ni u jednog bolesnika liječenog lijekom Perjeta plus trastuzumabom i FEC-om, a nakon toga lijekom Perjeta plus trastuzumabom i docetakselom.
English: USA
Croatian: Njemačka
English: The loading dose of 8 mg/kg of trastuzumab IV should be readministered over approximately 90 minutes, followed by a maintenance dose of 6 mg/kg IV administered every 3 weeks thereafter.
Croatian: 90 minuta, a nakon toga nastaviti liječenje intravenskom dozom održavanja od 6 mg/kg, svaka 3 tjedna.
English: Perjeta in combination with TCH (docetaxel, carboplatin and trastuzumab).
Croatian: FEC: 5-fluorouracil, epirubicin, ciklofosfamid; TCH: docetaksel, karboplatin i trastuzumab, CMH: CochranMantel-Haenszel
English: Batch
Croatian: Osip
English: What is Javlor?
Croatian: Što je Javlor?
English: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom26 September 2014
Croatian: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom26. rujna 2014.
English: It may request a re-examination of the opinion within 15 days of receipt of notification of this negative opinion.
Croatian: Tvrtka može zatražiti ponovno ispitivanje mišljenja u roku 15 dana od primitka obavijesti o negativnom mišljenju.
English: If you are in a clinical trial and need more information about your treatment, contact the doctor who is giving it to you.
Croatian: Ako sudjelujete u kliničkom ispitivanju te Vam je potrebno više informacija o Vašem liječenju, obratite se liječniku koji Vam pruža liječenje.
English: The full European Public Assessment Report for Javlor can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Croatian: Sažetak mišljenja Povjerenstva za lijekove za rijetke i teške bolesti o lijeku Javlor dostupan je na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: In addition, there was no benefit in terms of other important measures of effectiveness, including overall survival (how long patients lived).
Croatian: Nadalje, nema koristi u smislu drugih važnih mjera djelotvornosti, uključujući ukupno preživljenje (koliko su dugo bolesnici živjeli).
English: The main measure of effectiveness was progression-free survival (how long patients lived without their disease getting worse).
Croatian: Glavna mjera djelotvornosti bilo je preživljenje bez progresije (koliko su dugo bolesnici živjeli bez pogoršanja bolesti).
English: Although there was an improvement in progression-free survival, this was considered to be small.
Croatian: Iako je prisutno poboljšanje u preživljenju bez progresije, isto se smatralo premalim.
English: What consequences does this refusal have for patients in clinical trials or compassionate use programmes?
Croatian: Koje posljedice ima ovo povlačenje za pacijente u kliničkim ispitivanjima ili u programima milosrdnog davanja lijekova?
English: The change concerned an extension of indication to add treatment of breast cancer.
Croatian: Promjena se odnosila na proširenje indikacije kako bi se dodalo liječenje raka dojke.
English: Javlor is a cancer medicine that has been authorised in the EU since September 2009.
Croatian: Javlor je citostatik koji je odobren za primjenu u EU-u od rujna 2009.
English: Refusal of a change to the marketing authorisation for Javlor (vinflunine) EMA/587197/2014
Croatian: Odbijanje izmjene odobrenja za stavljanje u promet lijeka Javlor (vinflunin) EMA/587197/2014
English: Therefore, at that point in time, the CHMP was of the opinion that the modest effect of Javlor in the treatment of breast cancer did not outweigh the additional risks observed.
Croatian: Stoga, u tom trenutku, CHMP je bio mišljenja da skromno djelovanje lijeka Javlor u liječenju raka dojke ne nadmašuje uočene dodatne rizike.
English: There are no consequences on the use of Javlor in its authorised indication.
Croatian: Nema posljedica za primjenu lijeka Javlor u ovoj odobrenoj indikaciji.
English: On 25 September 2014, the Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion, recommending the refusal of a change to the marketing authorisation for the medicinal product Javlor.
Croatian: Dana 25. rujna 2014., Odbor za lijekove za humanu uporabu (CHMP) usvojio je negativno mišljenje, preporučujući odbijanje izmjene odobrenja za stavljanje u promet lijeka Javlor.
English: Compared with patients given capecitabine alone, more patients receiving Javlor plus capecitabine experienced side effects including neutropenia (abnormally low blood levels of white blood cells), gastrointestinal events such as constipation, nausea and vomiting and stomach ache, fatigue and nervous system disorders such as damage to the nerves in the extremities.
Croatian: U usporedbi s bolesnicima koji su primali samo monoterapiju kapecitabina, veći broj bolesnika koji su primali lijek Javlor i kapecitabin iskusilo je nuspojave uključujući i neutropeniju (abnormalno niske razine krvi bijelih krvnih stanica),k gastrointestinalne događaje, poput zatvora, mučnine i trbuhobolje, iscrpljenosti i poremećaja živčanog sustava, poput oštećenja živčanog sustava u ekstremitetima.
English: How is Javlor expected to work?
Croatian: Kako je Javlor trebao djelovati?
English: The company presented the results of a main study involving 770 patients with advanced breast cancer previously treated with or resistant to an anthracycline and who are taxane resistant.
Croatian: Tvrtka je dostavila rezultate glavnog ispitivanja koje je obuhvatilo 770 bolesnika s uznapredovanim rakom dojke, a koji su prethodno liječeni ili su rezistentni na antraciklin i koji su rezistentni na taksan.
English: Javlor contains the active substance vinflunine and is available as a concentrate for solution for infusion (drip) into a vein.
Croatian: Javlor sadrži djelatnu tvar vinflunin i dostupan je kao koncentrat za otopinu za infuziju (drip) u venu.
English: Refusal of a change to the marketing authorisation for Javlor (vinflunine)
Croatian: Odbijanje izmjene odobrenja za stavljanje u promet lijeka Javlor (vinflunin)
English: What is happening with Javlor for the treatment of transitional-cell carcinoma of the urothelial tract?
Croatian: Što se događa s Javlor kada je riječ o liječenju karcinoma prijelaznih stanica urotelijalnog trakta?
English: What were the CHMP's main concerns that led to the refusal of the change to the marketing authorisation?
Croatian: Koji su glavni razlozi za zabrinutost CHMP-a koji su rezultirali odbijanjem izmjene odobrenja za stavljanje lijeka u promet?
English: The CHMP noted that the effectiveness of Javlor in combination with capecitabine had not been sufficiently demonstrated.
Croatian: CHMP je napomenuo da djelotvornost lijeka Javlor u kombinaciji s kapecitabinom nije u dostatnoj mjeri dokazana.
English: Javlor was also expected to be used in combination with the cancer medicine capecitabine for the treatment of adult patients with locally advanced or metastatic breast cancer.
Croatian: Očekivano je da će se Javlor koristiti u kombinaciji sa citostatikom kapecitabinom za liječenje odraslih bolesnika s lokalnim uznapredovanim ili metastatskim rakom dojke.
English: The company informed the CHMP that there are no consequences for patients currently included in clinical trials with Javlor.
Croatian: Tvrtka je obavijestila CHMP da nema posljedica za klinička ispitivanja lijekova Javlor koja su trenutno u tijeku.
English: The active substance in Javlor, vinflunine, belongs to the group of cancer medicines known as ‘vinca alkaloids'.
Croatian: Djelatna tvar lijeka Javlor, vinflunin, ubraja se u grupu citostatika poznatih pod nazivom „vinka alkaloidi“
English: It was to be used in patients previously treated with, or resistant to, another type of cancer medicine called an anthracycline and who are also resistant to a third type of cancer medicines called taxanes.
Croatian: Također se trebao koristiti u bolesnika koji su prethodno liječeni, ili su rezistentni na, drugi tip citostatika naziva antraciklin, te koji su također rezistentni na treći tip citostatika naziva taksani.
English: It is already used to treat adults with advanced or metastatic ‘transitional-cell carcinoma of the urothelial tract' (a cancer that affects the lining of the bladder and the rest of the urinary tract).
Croatian: Već se koristi za liječenje odraslih osoba s uznapredovanim ili metastatskim „karcinomima prijelaznih stanica urotelijalnog trakta“ (rak koji zahvaća ovojnicu mjehura i ostatak urinarnog trakta). „Metastatski“ znači da se rak proširio na druge dijelove tijela.
English: In the study, Javlor given together with capecitabine was compared with capecitabine alone.
Croatian: U ispitivanju, Javlor se primjenjivao zajedno s kapecitabinom te je uspoređen s monoterapijom kapecitabinom.
English: Hence, the CHMP recommended that the change to the marketing authorisation be refused.
Croatian: Stog, CHMP je preporučio odbijanje izmjena odobrenja za stavljanje lijeka u promet.
English: The company that applied for the change to the authorisation is Pierre Fabre Médicament.
Croatian: Pierre Fabre Médicament je tvrtka koja je podjela zahtjev za izmjenu odobrenja za stavljanje lijeka u promet.
English: By attaching to tubulin in cancer cells, vinflunine stops the formation of the skeleton, preventing the division and spread of the cancer cells.
Croatian: Vezuje se na stanični protein naziva tubulin, koji igra značajnu ulogu u formiranju internog „kostura“ koji je potreban stanicama kako bi im se omogućila dioba Vezivanjem na tubulin u stanicama raka, vinflunin zaustavlja formiranje kostura, sprječavajući dijeljenje i širenje stanica raka.
English: What was Javlor expected to be used for?
Croatian: Koja je očekivana uporaba lijeka Javlor?
English: 1 Previously known as DuoCover.
Croatian: 1 Prethodno poznat kao DuoCover.
English: Both active substances have been available in the European Union (EU) for a number of years.
Croatian: Obje djelatne tvari dostupne su u Europskoj uniji (EU) već niz godina.
English: This summary was last updated in 03-2016.
Croatian: Ovaj sažetak je posljednji put ažuriran u 03.2016.
English: Acetylsalicylic acid has been available for over 100 years.
Croatian: Acetilsalicilna kiselina dostupna je već više od 100 godina.
English: It can be used in the following groups of patients who have a condition known as ‘acute coronary syndrome':
Croatian: Može se primjenjivati u sljedećim skupinama bolesnika koji boluju od stanja poznatog pod nazivom „akutni koronarni sindrom”:
English: It also presented the results of 3 previous studies involving over 61,000 patients with unstable angina or who had had a heart attack.
Croatian: Tvrtka je predstavila također rezultate triju prethodnih ispitivanja koja su uključivala više od 61 000 bolesnika s nestabilnom anginom ili bolesnika koji su imali srčani udar.
English: The full EPAR for Clopidogrel/Acetylsalicylic acid Zentiva can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Croatian: Cjeloviti EPAR za lijek Klopidogrel/acetilsalicilna kiselina Zentiva nalazi se na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: It is available as tablets containing 75 mg clopidogrel, either with 75 mg or 100 mg acetylsalicylic acid.
Croatian: Dostupan je u obliku tableta koje sadrže 75 mg klopidogrela sa 75 ili 100 mg acetilsalicilne kiseline.
English: Clopidogrel/Acetylsalicylic acid Zentiva must not be used during the last three months of pregnancy.
Croatian: Lijek Klopidogrel/acetilsalicilna kiselina Zentiva ne smije se uzimati tijekom posljednjih triju mjeseca trudnoće.
English: The name of the medicine was changed to Clopidogrel/Acetylsalicylic acid Zentiva on 15 January 2016.
Croatian: Naziv lijeka promijenjen je u Klopidogrel/acetilsalicilna kiselina Zentiva 15. siječnja 2016.
English: Clopidogrel has been authorised since 1998 for reducing platelet aggregation, and is often used in combination with acetylsalicylic acid.
Croatian: Klopidogrel je odobren od 1998. kao lijek za smanjenje agregacije trombocita i često se koristi u kombinaciji s acetilsalicilnom kiselinom.
English: This means that they help to prevent blood cells called platelets from sticking together and forming clots, thus helping to prevent another heart attack.
Croatian: To znači da pomažu u sprečavanju toga da se krvne stanice koje se nazivaju trombociti sljepljuju i stvaraju krvne ugruške, pomažući tako u sprečavanju pojave novog srčanog udara.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Clopidogrel/Acetylsalicylic acid Zentiva.
Croatian: Objašnjava kako je Odbor za lijekove za humanu uporabu (CHMP) ocijenio lijek da bi donio svoje mišljenje u korist izdavanja odobrenja za stavljanje lijeka u promet te preporuke o uvjetima za primjenu lijeka Klopidogrel/acetilsalicilna kiselina Zentiva.
English: This stops the platelets becoming ‘sticky', reducing the risk of a blood clot forming.
Croatian: Time se sprečava da trombociti postanu „ljepljivi” što smanjuje rizik od stvaranja krvnih ugrušaka.
English: The combination of the two active substances has an additive effect, reducing the risk of blood clots forming more than either medicine alone.
Croatian: Kombinacija ovih dviju djelatnih tvari ima zbrojni učinak tako što smanjuje rizik od stvaranja krvnih ugrušaka u većoj mjeri nego svaki od tih lijekova pojedinačno.
English: • patients being treated for heart attack with ST-segment elevation, when the doctor thinks that they would benefit from treatment to dissolve blood clots.
Croatian: • u bolesnika koji primaju terapiju za srčani udar s „elevacijom ST-segmenta” u slučaju kada liječnik smatra da će im liječenje koristiti za otapanje krvnih ugrušaka.
English: Because the two active substances have been used together for a number of years, the company presented the results of studies showing that the active substances in Clopidogrel/Acetylsalicylic acid Zentiva are absorbed in the body in the same way when taken in a single tablet as when the two medicines are taken separately.
Croatian: S obzirom na to da se te dvije djelatne tvari zajedno koriste već niz godina, tvrtka je predstavila rezultate ispitivanja koji pokazuju da se djelatne tvari u lijeku Klopidogrel/acetilsalicilna kiselina Zentiva apsorbiraju u tijelo na isti način kao i kada se uzimaju kao pojedinačna tableta kada se ta dva lijeka uzimaju zasebno.
English: • patients who have unstable angina (a severe type of chest pain) or who have had a heart attack with no ‘ST-segment elevation' (an abnormal reading on the ECG or electrocardiogram), including those who are having a stent (a short tube) inserted into an artery to prevent it from closing up;
Croatian: • u bolesnika koji imaju nestabilnu anginu (teži oblik boli u prsima) ili u bolesnika koji su imali srčani udar bez „elevacije ST-segmenta” (abnormalan nalaz elektrokardiograma ili EKG-a), uključujući u bolesnika koji imaju ugrađen stent (kratku cijev) u arteriji kako bi se spriječilo njezino zatvaranje;
English: For more information about treatment with Clopidogrel/Acetylsalicylic acid Zentiva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Croatian: Više informacija o terapiji lijekom Klopidogrel/acetilsalicilna kiselina Zentiva pročitajte u uputi o lijeku (također dio EPAR-a) ili se obratite svom liječniku ili ljekarniku.
English: The most common side effects with Clopidogrel/Acetylsalicylic acid Zentiva (seen in between 1 and 10 patients in 100) are haematoma (a collection of blood under the skin), epistaxis (nosebleeds), gastrointestinal haemorrhage (bleeding in the stomach or gut), diarrhoea, abdominal pain (stomach ache), dyspepsia (heartburn), bruising, and bleeding where the skin is punctured.
Croatian: Najčešće su nuspojave lijeka Klopidogrel/acetilsalicilna kiselina Zentiva (zabilježene u između 1 i 10 na 100 bolesnika) hematomi (nakupljanje krvi pod kožom), epistaksa (krvarenje iz nosa), gastrointestinalno krvarenje (krvarenje u želucu ili crijevima) proljev, abdominalna bol (bol u trbuhu), dispepsija (žgaravica), pojava modrica i krvarenje na mjestu uboda na koži.
English: Acetylsalicylic acid stops the platelets sticking together by blocking an enzyme called prostaglandin cyclo-oxygenase.
Croatian: Acetilsalicilna kiselina onemogućuje sljepljivanje trombocita blokiranjem enzima koji se naziva prostaglandin ciklooksigenaza.
English: This reduces the production of a substance called thromboxane, which normally helps clots to form by attaching platelets together.
Croatian: Time se smanjuje proizvodnja tvari koja se naziva tromboksan, a koja obično pomaže u stvaranju ugrušaka vezivanjem trombocita.
English: This document is a summary of the European Public Assessment Report (EPAR) for Clopidogrel/Acetylsalicylic acid Zentiva.
Croatian: Ovo je sažetak europskoga javnog izvješća o ocjeni dokumentacije (EPAR) o lijeku Klopidogrel/acetilsalicilna kiselina Zentiva.
English: It must not be used in patients who have a disease that is causing bleeding, such as stomach ulcer or bleeding in the brain, or in patients with mastocytosis (high blood levels of certain white blood cells called mast cells).
Croatian: Ne smije se primjenjivati u bolesnika koji boluju od bolesti koje uzrokuju krvarenje, kao što su čir na želucu ili krvarenje u mozgu, ili u bolesnika s mastocitozom (visokim razinama određenih bijelih krvnih stanica, mastocita, u krvi).
English: Results from the 3 studies in patients with unstable angina or who had had a heart attack showed that the combination of clopidogrel and acetylsalicylic acid taken as separate tablets was more effective at preventing events such as heart attacks than acetylsalicylic acid alone.
Croatian: Rezultati triju ispitivanja na bolesnicima s nestabilnom anginom ili bolesnicima koji su imali srčani udar pokazali su da je uzimanje kombinacije klopidogrela i acetilsalicilne kiseline kao zasebnih tableta djelotvornije u sprečavanju stanja kao što su srčani udari od uzimanja samo acetilsalicilne kiseline.
English: Clopidogrel stops the platelets sticking together by blocking a substance called ADP from attaching to a special receptor on their surface.
Croatian: Klopidogrel onemogućuje sljepljivanje trombocita tako što onemogućuje da se tvar naziva ADP vezuje za poseban receptor na njihovoj površini.
English: Clopidogrel/Acetylsalicylic acid Zentiva is a medicine that contains two active substances, clopidogrel and acetylsalicylic acid (also known as aspirin).
Croatian: Klopidogrel/acetilsalicilna kiselina Zentiva lijek je koji sadrži dvije djelatne tvari, klopidogrel i acetilsalicilnu kiselinu (također poznatu kao aspirin).
English: The CHMP noted that Clopidogrel/Acetylsalicylic acid Zentiva is comparable to clopidogrel and acetylsalicylic acid tablets taken separately, and concluded that combining both active substances in a single Clopidogrel/Acetylsalicylic acid Zentiva tablet simplifies treatment for patients as they will need to take fewer tablets.
Croatian: CHMP je smatrao da je lijek Klopidogrel/acetilsalicilna kiselina Zentiva usporediv s tabletama klopidogrela i acetilsalicilne kiseline kada se uzimaju zasebno i zaključio je da se objedinjavanjem tih dviju djelatnih tvari u jedinstveni lijek Klopidogrel/acetilsalicilna kiselina Zentiva pojednostavljuje liječenje za bolesnike jer će tako trebati uzimati manji broj tableta.
English: Clopidogrel/Acetylsalicylic acid Zentiva is used to prevent problems caused by blood clots, such as a heart attack, in adults who are already taking both clopidogrel and acetylsalicylic acid as separate tablets.
Croatian: Klopidogrel/acetilsalicilna kiselina Zentiva koristi se za sprečavanje problema uzrokovanih ugrušcima krvi kao što je srčani udar, i to u odraslih osoba koje već uzimaju klopidogrel i acetilsalicilnu kiselinu kao zasebne tablete.
English: Clopidogrel/Acetylsalicylic acid Zentiva must not be used in people who are hypersensitive (allergic) to clopidogrel, non steroidal anti-inflammatory drugs (such as acetylsalicylic acid) or any of the other ingredients in Clopidogrel/Acetylsalicylic acid Zentiva.
Croatian: Lijek Klopidogrel/acetilsalicilna kiselina Zentiva ne smije se primjenjivati u osoba koje su preosjetljive (alergične) na klopidogrel, nesteroidne protuupalne lijekove (kao što je acetilsalicilna kiselina) ili bilo koji drugi sastojak lijeka.
English: The European Commission granted a marketing authorisation valid throughout the EU for DuoCover on 15 March 2010.
Croatian: Europska komisija izdala je odobrenje za stavljanje u promet koje je za lijek Klopidogrel/acetilsalicilna kiselina Zentiva na snazi u Europskoj uniji od 15. ožujka 2010.
English: It must not be used in patients who have severely reduced liver or kidney function, or who have a medical condition that includes a combination of asthma, rhinitis (stuffy and runny nose) and nasal polyps (growths in the lining of the nose).
Croatian: Ne smije se primjenjivati u bolesnika s teškim oblikom smanjene funkcije rada jetre ili bubrega ili u bolesnika sa zdravstvenim stanjem koje uključuje kombinaciju astme, rinitisa (začepljen nos i hunjavica) i nazalnih polipa (izraslina u sluznici nosa).
English: The Committee therefore decided that Clopidogrel/Acetylsalicylic acid Zentiva's benefits are greater than its risks and recommended that it be given marketing authorisation.
Croatian: CHMP je odlučio da koristi od lijeka Klopidogrel/acetilsalicilna kiselina Zentiva nadmašuju s njim povezane rizike te je preporučio izdavanje odobrenja za stavljanje lijeka u promet.
English: Both active substances in Clopidogrel/Acetylsalicylic acid Zentiva, clopidogrel and acetylsalicylic acid, are antiplatelet medicines.
Croatian: Obje djelatne tvari u lijeku Klopidogrel/acetilsalicilna kiselina Zentiva, klopidogrel i acetilsalicilna kiselina, lijekovi su protiv agregacije trombocita.
English: Clopidogrel/Acetylsalicylic acid Zentiva is taken as one tablet once a day in place of the clopidogrel and acetylsalicylic acid tablets that the patient has already been taking separately.
Croatian: Klopidogrel/acetilsalicilna kiselina Zentiva uzima se kao jedna tableta jednom dnevno umjesto tableta klopidogrela i acetilsalicilne kiseline koje je bolesnik prethodno zasebno uzimao.
English: Other information about Clopidogrel/Acetylsalicylic acid Zentiva:
Croatian: Ostale informacije o lijeku Klopidogrel/acetilsalicilna kiselina Zentiva:
English: Clopidogrel/Acetylsalicylic acid Zentiva was shown to be comparable to clopidogrel and acetylsalicylic acid taken separately, and can therefore be used in place of the clopidogrel and acetylsalicylic acid tablets that the patients have already been taking.
Croatian: Pokazalo se da je lijek Klopidogrel/acetilsalicilna kiselina Zentiva usporediv s klopidogrelom i acetilsalicilnom kiselinom kada se uzimaju zasebno i da se stoga može koristiti umjesto tableta klopidogrela i acetilsalicilne kiseline koje su bolesnici prethodno već uzimali.
English: For the full list of all side effects reported with Clopidogrel/Acetylsalicylic acid Zentiva, see the package leaflet.
Croatian: Potpuni popis nuspojava zabilježenih pri primjeni lijeka Klopidogrel/acetilsalicilna kiselina Zentiva potražite u uputi o lijeku.
English: What is the risk associated with Clopidogrel/Acetylsalicylic acid Zentiva?
Croatian: Koji su rizici povezani s lijekom Klopidogrel/acetilsalicilna kiselina Zentiva?
English: What benefit has Clopidogrel/Acetylsalicylic acid Zentiva shown during the studies?
Croatian: Koje su koristi lijeka Klopidogrel/acetilsalicilna kiselina Zentiva dokazane u ispitivanjima?