FrancophonIA/ELRC3.0 huggingface dataset:
English: Distribution Quetiapine is approximately 83% bound to plasma proteins.
Slovenian: Porazdelitev Približno 83% kvetiapina se veže na beljakovine v plazmi.
English: Quetiapine and several of its metabolites (including norquetiapine) were found to be weak inhibitors of human cytochrome P450 1A2, 2C9, 2C19, 2D6 and 3A4 activities in vitro.
Slovenian: Kvetiapin in več njegovih presnovkov (vključno z norkvetiapinom) in vitro rahlo zavirajo delovanje encimov 1A2, 2C9, 2C19, 2D6 in 3A4 humanega citokroma P450.
English: In a monotherapy relapse prevention study, patients with depressive episodes stabilised on open-label Seroquel XR treatment for at least 12 weeks were randomised to either Seroquel XR once daily or placebo for up to 52 weeks.
Slovenian: V študiji preprečevanja recidivov z monoterapijo so bolnike z obdobji depresije vsaj 12 tednov stabilizirane v odprti fazi zdravljenja z zdravilom Seroquel SR, randomizirali na Seroquel SR enkrat na dan ali na placebo za obdobje do 52 tednov.
English: Seroquel XR can be used to treat several illnesses, such as:
Slovenian: Zdravilo Seroquel SR se lahko uporablja za zdravljenje več bolezni, npr.:
English: It is important that any change in the inducer is gradual, and if required, replaced with a non-inducer (e.g. sodium valproate) (see section 4.4).
Slovenian: Pomembno je, da je vsaka sprememba v zdravljenju z induktorjem postopna, in če je treba, lahko induktor nadomestimo z zdravilom, ki ne inducira jetrnih encimov (npr. natrijevim valproatom) (glejte poglavje 4.4).
English: Rhinitis
Slovenian: rinitis
English: The incidences of shifts in TSH was 3.2 % for quetiapine versus 2.7 % for placebo.
Slovenian: Incidenca sprememb TSH je bila 3,2 % s kvetiapinom in 2,7 % s placebom.
English: In a specific interaction study in psychotic patients, however, no increase in the cytochrome P450 activity was found after administration of quetiapine.
Slovenian: Toda v specifični študiji medsebojnega delovanja pri psihotičnih bolnikih po uporabi kvetiapina niso ugotovili večje aktivnosti citokroma P450.
English: Elevations in blood creatine phosphokinase
Slovenian: Preiskave zvišanje kreatinfosfokinaze v krvi
English: Due to lack of robust data, a decision must be made whether to discontinue breast-feeding or to discontinue Seroquel therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Slovenian: Zaradi pomanjkanja zanesljivih podatkov se je treba odločiti bodisi za prenehanje dojenja bodisi za prenehanje zdravljenja z zdravilom Seroquel, upoštevaje koristi dojenja za otroka in koristi zdravljenja za žensko.
English: • A long-lasting and painful erection (priapism).
Slovenian: • dolgotrajna ali boleča erekcija (priapizem).
English: Quetiapine treatment has been associated with orthostatic hypotension and related dizziness (see Section 4.8) which, like somnolence has onset usually during the initial dose-titration period.
Slovenian: Zdravljenje s kvetiapinom je bilo povezano z ortostatsko hipotenzijo in spremljajočo omotico (glejte poglavje 4.8), ki se po navadi pojavi med uvodnim obdobjem prilagajanja odmerka, tako kot zaspanost.
English: • You have low blood pressure.
Slovenian: • nizek krvni tlak stoje.
English: Quetiapine should be used with caution in patients at risk for aspiration pneumonia.
Slovenian: Kvetiapin je treba uporabljati previdno pri bolnikih z večjim tveganjem za aspiracijsko pljučnico.
English: In patients stabilised on Seroquel immediate release 400 mg to 800 mg, efficacy was maintained when patients were switched to an equivalent daily dose of Seroquel XR given once daily.
Slovenian: Pri bolnikih, stabiliziranih na 400 do 800 mg zdravila Seroquel, se je učinkovitost ohranila, ko so prešli na enak dnevni odmerek zdravila Seroquel SR enkrat na dan.
English: The mean plasma clearance of quetiapine was reduced by approximately 25% in subjects with severe renal impairment (creatinine clearance less than 30 ml/min/1.73 m2), but the individual clearance values are within the range for normal subjects.
Slovenian: Pri bolnikih s hudo okvaro ledvic se je povprečni plazemski očistek kvetiapina zmanjšal za približno 25 % (očistek kreatinina manj kot 30 ml/min/1,73 m2), toda individualne vrednosti očistka so bile znotraj območja za normalne osebe.
English: Co-administration of quetiapine and phenytoin (another microsomal enzyme inducer) caused a greatly increased clearance of quetiapine by approx. 450%.
Slovenian: Sočasno zdravljenje s kvetiapinom in fenitoinom (induktor mikrosomalnih encimov) povzroči izrazito povečanje očistka kvetiapina za približno 450 %.
English: Abnormal dreams and nightmares, Suicidal ideation and suicidal behaviour
Slovenian: Psihiatrične motnje nenormalne sanje in nočne more, samomorilno razmišljanje in samomorilno vedenje20
English: • Fits (seizures).
Slovenian: • napadi krčev (konvulzije).
English: On the basis of this, concomitant use of quetiapine with CYP3A4 inhibitors is contraindicated.
Slovenian: Sočasna uporaba kvetiapina z zaviralci CYP3A4 je zato kontraindicirana.
English: As Seroquel XR has several indications, the safety profile should be considered with respect to the individual patient's diagnosis and the dose being administered.
Slovenian: Ker ima zdravilo Seroquel SR več indikacij, je treba varnostne značilnosti obravnavati glede na diagnozo posameznega bolnika in uporabljeni odmerek.
English: Neuroleptic Malignant Syndrome:
Slovenian: Nevroleptični maligni sindrom:
English: Gender: The pharmacokinetics of quetiapine does not differ between men and women.
Slovenian: Farmakokinetika kvetiapina se med moškimi in ženskami ne razlikuje.
English: 6 film-coated tablets 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 60 film-coated tablets 100 film-coated tablets
Slovenian: 6 filmsko obloženih tablet 20 filmsko obloženih tablet 30 filmsko obloženih tablet 50 filmsko obloženih tablet 60 filmsko obloženih tablet 100 filmsko obloženih tablet
English: Due to lack of robust data, a decision must be made whether to discontinue breast-feeding or to discontinue Seroquel XR therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Slovenian: Zaradi pomanjkanja zanesljivih podatkov se je treba odločiti bodisi za prenehanje dojenja bodisi za prenehanje zdravljenja z zdravilom Seroquel SR, upoštevaje koristi dojenja za otroka in koristi zdravljenja za žensko.
English: Before you stop taking any of your medicines, please talk to your doctor first.
Slovenian: Preden nehate jemati katerokoli zdravilo, se morate posvetovati z zdravnikom.
English: Table 2 ADRs in children and adolescents associated with quetiapine therapy that occur in a higher frequency than adults, or not identified in the adult population
Slovenian: Preglednica 2 Neželeni učinki pri otrocih in mladostnikih, povezani z zdravljenjem s kvetiapinom in ki se pojavljajo z večjo pogostnostjo kot pri odraslih ali pri odraslih niso bili ugotovljeni
English: Constipation represents a risk factor for intestinal obstruction.
Slovenian: Zaprtost predstavlja dejavnik tveganja za zaporo črevesa.
English: In clinical trials for treatment of patients with bipolar depression and major depressive disorder, onset was usually within the first 3 days of treatment and was predominantly of mild to moderate intensity.
Slovenian: V kliničnih preskušanjih za zdravljenje bolnikov z bipolarno depresijo in veliko depresivno motnjo so se ponavadi pojavili v prvih 3 dneh zdravljenja in so bili pretežno blagi do zmerni.
English: In patients who responded to quetiapine, when comparing continued treatment with quetiapine to switching to lithium, the results indicated that a switch to lithium treatment does not appear to be associated with an increased time to recurrence of a mood event.
Slovenian: Pri bolnikih, ki so se odzvali na akutno zdravljenje s kvetiapinom, rezultati primerjave nadaljevalnega zdravljenja s kvetiapinom in prehoda na litij kažejo, da prehod na litij ni povezan s podaljšanjem časa do naslednjega recidiva motnje razpoloženja.
English: There was no evidence of genotoxicity in a series of in vitro and in vivo genotoxicity studies.
Slovenian: V vrsti študij genotoksičnosti in vitro in in vivo niso ugotovili genotoksičnih učinkov.
English: in elderly patients.
Slovenian: Starejši bolniki:
English: Long-term efficacy and safety in patients with MDD has not been evaluated as add-on therapy, however long-term efficacy and safety has been evaluated in adult patients as monotherapy (see Section 5.1).
Slovenian: Dolgoročna učinkovitost in varnost pri bolnikih z veliko depresivno motnjo (MDD) nista ocenjeni v primeru, ko se uporabi kot dodatno zdravilo, vendar pa sta bili dolgoročna učinkovitost in varnost ocenjeni pri odraslih bolnikih v monoterapiji (glejte poglavje 5.1).
English: A retrospective study of children and adolescents who received valproate, quetiapine, or both, found a higher incidence of leucopenia and neutropenia in the combination group versus the monotherapy groups.
Slovenian: Retrospektivna študija otrok in mladostnikov, ki so prejemali valproat, kvetiapin ali oba, je ugotovila večjo incidenco levkopenije in nevtropenije v skupini, ki je prejemala kombinirano zdravljenje, kot v skupinah, ki sta prejemali monoterapijo.
English: The mean clearance of quetiapine in the elderly is approximately 30 to 50% lower than that seen in adults aged 18 to 65 years.
Slovenian: Pri starejših bolnikih je povprečni očistek kvetiapina za približno 30 do 50 % manjši kot pri odraslih bolnikih, starih od 18 do 65 let.
English: Dose reduction or more gradual titration should be considered if orthostatic hypotension occurs, especially in patients with underlying cardiovascular disease.
Slovenian: Če se pojavi ortostatska hipotenzija, pride v poštev zmanjšanje odmerka ali postopnejše titriranje, zlasti pri bolnikih s srčno žilnimi boleznimi.
English: The safety results showed a higher incidence of extrapyramidal symptoms reported in 16.8% of patients in the lithium add-on group and 6.6% in the placebo add-on group, the majority of which consisted of tremor, reported in 15.6% of the patients in the lithium add-on group and 4.9% in the placebo add-on group.
Slovenian: Rezultati o varnosti so pokazali večjo incidenco ekstrapiramidnih simptomov v skupini z dodatkom litija (16,8 %) kot v skupini z dodatkom placeba (6,6 %); večinoma je šlo za tremor opažali so ga pri 15,6 % bolnikov v skupini z dodatkom litija in pri 4,9 % bolnikov v skupini z dodatkom placeba.
English: Long-term efficacy and safety in patients with MDD has not been evaluated as add-on therapy, however long-term efficacy and safety has been evaluated in adult patients as monotherapy (see below).
Slovenian: Dolgoročna učinkovitost in varnost pri bolnikih z veliko depresivno motnjo nista ocenjeni pri uporabi kot dodatno zdravilo, vendar pa sta bili dolgoročna učinkovitost in varnost ocenjeni pri odraslih bolnikih v monoterapiji (glejte spodaj).
English: Keep the Seroquel tablets with you.
Slovenian: S seboj vzemite tablete zdravila Seroquel.
English: Do not take Seroquel if you are taking any of the following medicines:
Slovenian: Ne jemljite zdravila Seroquel, če jemljete katero od naštetih zdravil:
English: • Feeling irritated.
Slovenian: • občutek razdražljivosti.
English: Clinical trials with quetiapine have shown that in addition to the known safety profile identified in adults (see section 4.8), certain adverse events occurred at a higher frequency in children and adolescents compared to adults (increased appetite, elevations in serum prolactin, vomiting, rhinitis and syncope), or may have different implications for children and adolescents (extrapyramidal symptoms and irritability) and one was identified that has not been previously seen in adult studies (increases in blood pressure).
Slovenian: Klinična preskušanja s kvetiapinom so pokazala, da so poleg znanih varnostnih značilnosti, ugotovljenih pri odraslih (glejte poglavje 4.8), nekateri neželeni učinki pri otrocih in mladostnikih pogostejši kot pri odraslih (večji apetit, zvišanje prolaktina v serumu, bruhanje, rinitis in sinkopa), ali pa imajo lahko za otroke in mladostnike drugačne implikacije (ekstrapiramidni simptomi in razdražljivost).
English: As with other antipsychotics, caution should be exercised when quetiapine is prescribed in patients with cardiovascular disease or family history of QT prolongation.
Slovenian: Kot pri drugih antipsihotikih, je tudi pri kvetiapinu potrebna pozornost pri bolnikih s srčno-žilnimi boleznimi ali družinsko anamnezo QT podaljšanja.
English: Based on these in vitro results, it is unlikely that co-administration of quetiapine with other drugs will result in clinically significant drug inhibition of cytochrome P450 mediated metabolism of the other drug.
Slovenian: Na podlagi teh rezultatov in vitro ni verjetno, da bi sočasna uporaba kvetiapina z drugimi zdravili klinično pomembno zavrla presnovo drugih zdravil s citokromom P450.
English: (17) HDL cholesterol: <40 mg/dL (1.025 mmol/L) males; <50 mg/dL (1.282 mmol/L) females at any time.
Slovenian: (17) Holesterol HDL: < 40 mg/dl (1.025 mmol/l) moški; < 50 mg/dl (1.282 mmol/l) ženske kadarkoli.
English: The mean dose of Seroquel XR was 160 mg/day.
Slovenian: Povprečni odmerek zdravila Seroquel SR je bil 160 mg/dan.
English: Anaphylactic reaction
Slovenian: anafilaktična reakcija
English: BATCH NUMBER LOT
Slovenian: ŠTEVILKA SERIJE LOT
English: The rate of dose titration may need to be slower, and the daily therapeutic dose lower, than that used in younger patients, depending on the clinical response and tolerability of the individual patient.
Slovenian: Hitrost povečevanja odmerka mora biti manjša in dnevni terapevtski odmerek nižji kot pri mlajših bolnikih, odvisno od klinične odzivnosti na zdravljenje in posameznikovega prenašanja zdravila.
English: Increases in blood pressure were reported in children and adolescents and increased appetite, extrapyramidal symptoms and elevations in serum prolactin were reported with higher frequency in children and adolescents than in adult patients (see sections 4.4 and 4.8).
Slovenian: Pri otrocih in mladostnikih je bilo opisano zvišanje krvnega tlaka; večji apetit, ekstrapiramidni simptomi in zvišanje prolaktina v serumu pa so bili pri otrocih in mladostnikih opisani pogosteje kot pri odraslih bolnikih (glejte poglavji 4.4 in 4.8).
English: Clinicians should therefore ensure that the lowest effective dose, starting with 50 mg/day, is used for treatment.
Slovenian: Zdravnik mora zato poskrbeti, da je za zdravljenje uporabljen najmanjši učinkoviti odmerek, začenši s 50 mg/dan.
English: Seroquel XR 400 mg/day, 600 mg/day and 800 mg/day were associated with statistically significant improvements in psychotic symptoms compared to placebo.
Slovenian: Zdravilo Seroquel SR 400 mg/dan, 600 mg/dan in 800 mg/dan je psihotične simptome statistično značilno bolj izboljšalo kot placebo.
English: • Barbiturates (for difficulty sleeping).
Slovenian: • barbiturate (za zdravljenje nespečnosti),
English: In clinical trials for treatment of patients with bipolar depression, onset was usually within the first 3 days of treatment and was predominantly of mild to moderate intensity.
Slovenian: V kliničnih preskušanjih zdravljenja bolnikov z bipolarno depresijo so se po navadi pojavili v prvih 3 dneh zdravljenja in so bili pretežno blagi do zmerni.
English: (30) In some patients, a worsening of more than one of the metabolic factors of weight, blood glucose and lipids was observed in clinical studies (See Section 4.4).
Slovenian: (30) V kliničnih raziskavah so pri nekaterih bolnikih opazili poslabšanje več kot enega od metabolnih dejavnikov - telesne mase, glukoze v krvi in lipidov (glejte poglavje 4.4).
English: This is because the combined effect of Seroquel and alcohol can make you sleepy.
Slovenian: Skupen učinek zdravila Seroquel in alkohola lahko povzroči zaspanost.
English: The number of patients with a mood event was 91 (22.5%) in the quetiapine group, 208 (51.5%) in the placebo group and 95 (26.1%) in the lithium treatment groups respectively.
Slovenian: Število bolnikov z epizodo motnje razpoloženja je bilo 91 (22,5%) v skupini bolnikov, ki je prejemala kvetiapin, 208 (51,5%) v skupini bolnikov, ki je prejemala placebo in 95 (26,1%) v skupini, ki je prejemala litij.
English: The most commonly reported Adverse Drug Reactions (ADRs) with quetiapine (≥10%) are somnolence, dizziness, headache, dry mouth, withdrawal (discontinuation) symptoms, elevations in serum triglyceride levels, elevations in total cholesterol (predominantly LDL cholesterol), decreases in HDL cholesterol, weight gain, decreased haemoglobin and extrapyramidal symptoms.
Slovenian: Neželeni učinki kvetiapina, o katerih so poročali najpogosteje (≥ 10 %), so zaspanost, omotica, suha usta, glavobol, odtegnitveni simptomi, zvišanje koncentracije trigliceridov v serumu, zvišanje koncentracije celokupnega holesterola (predvsem LDL holesterola), znižanje koncentracije HDL
English: The AUC and Cmax for the active metabolite, norquetiapine, were higher, approximately 62% and 49% in children (10-12 years), respectively and 28% and 14% in adolescents (13-17 years), respectively, compared to adults.
Slovenian: AUC in Cmax aktivnega presnovka norkvetiapina sta bili pri otrocih (starih od 10 do 12 let) višji kot pri odraslih (AUC približno 62 %, Cmax približno 49 %), prav tako tudi pri mladostnikih (starih od 13 do 17 let) (AUC približno 28 %, Cmax približno 14 %).
English: Hyperprolactina emia decreases in total T4 decreases in free T4 decreases in total T3 increases in TSH
Slovenian: Bolezni endokrinega sistema hiperprolaktine mija,15, znižanje celotnega T4 znižanje prostega T4 znižanje celotnega T3 zvišanje TSH 24
English: • Seroquel can be taken with or without food.
Slovenian: • Zdravilo Seroquel lahko vzamete s hrano ali brez.
English: This is because the combined effect of Seroquel XR and alcohol can make you sleepy.
Slovenian: Skupen učinek zdravila Seroquel SR in alkohola lahko povzroči zaspanost.
English: Changes in thyroid function tests have also been observed in children and adolescents.
Slovenian: Pri otrocih in mladostnikih so opazili tudi spremembe v preiskavah delovanja ščitnice.
English: Concomitant use of quetiapine and thioridazine caused an increased clearance of quetiapine with approx. 70%.
Slovenian: Pri sočasni uporabi kvetiapina in tioridazina se poveča očistek kvetiapina za približno 70 %.
English: As with other antipsychotics and antidepressants, Seroquel XR should be used with caution in the elderly, especially during the initial dosing period.
Slovenian: Tako kot druga antipsihotična in antidepresivna zdravila je potrebno zdravilo Seroquel SR pri starejših bolnikih uporabljati previdno, še posebej v začetnem obdobju uporabe.
English: Seroquel XR 150 mg and 300 mg/day, given as add-on treatment to ongoing antidepressant therapy (amitriptyline, bupropion, citalopram, duloxetine, escitalopram, fluoxetine, paroxetine, sertraline or venlafaxine) demonstrated superiority over antidepressant therapy alone in reducing depressive symptoms as measured by improvement in MADRS total score (LS mean change vs. placebo of 2-3.3 points).
Slovenian: Seroquel SR 150 mg in 300 mg/dan kot dodatek že potekajočemu antidepresivnemu zdravljenju (amitriptilin, bupropion, citalopram, duloksetin, escitalopram, fluoksetin, paroksetin, sertralin ali venlafaksin) je v primerjavi z antidepresivno terapijo samo superiorno zmanjšal depresivne simptome; kot merilo je bilo uporabljeno izboljšanje celotnega seštevka po MADRS
English: Extrapyramidal symptoms3, 4
Slovenian: Bolezni živčevja ekstrapiramidni simptomi3, 4
English: Renal impairment: Dosage adjustment is not necessary in patients with renal impairment.
Slovenian: Okvara ledvic: Pri bolnikih z okvaro ledvic prilagoditev odmerka ni potrebna.
English: The effect size of the 600 mg and 800 mg doses was greater than that of the 400 mg dose.
Slovenian: Učinek 600-mg in 800-mg odmerka je bil večji kot
English: Venous Thromboembolism (VTE)
Slovenian: Venska tromboembolija (VTE)
English: Steady-state peak molar concentrations of the active metabolite norquetiapine are 35% of that observed for quetiapine.
Slovenian: Koncentracija v ravnotežnem stanju aktivnega metabolita norkvetiapina je 35 % delež koncentracije opažene pri kvetiapinu.
English: Pharmacokinetic data were sampled in 9 children aged 10-12 years old and 12 adolescents, who were on steady-state treatment with 400 mg quetiapine twice daily.
Slovenian: Farmakokinetični podatki so bili zbrani pri 9 otrocih, starih od 10 do 12 let, in pri 12 mladostnikih, ki so dobivali 400 mg kvetiapina dvakrat na dan in so bili s tem zdravljenjem v stanju dinamičnega ravnovesja.
English: • Combination of fever, flu-like symptoms, sore throat, or any other infection with very low white blood cell count, a condition called agranulocytosis.
Slovenian: • kombinacija zvišane telesne temperature, gripi podobnih simptomov, vnetega žrela ali kakšne druge okužbe z zelo majhnim številom belih krvnih celic (stanje imenovano agranulocitoza),
English: For more convenient dosing, patients who are currently being treated with divided doses of immediate release Seroquel tablets may be switched to Seroquel XR at the equivalent total daily dose taken once daily.
Slovenian: Za enostavnejše odmerjanje lahko bolniki, ki trenutno dobivajo deljene odmerke tablet Seroquel filmsko obložene tablete, preidejo na zdravilo Seroquel SR v enakem celotnem dnevnem odmerku, ki ga vzamejo enkrat na dan. Potrebne utegnejo biti individualne prilagoditve odmerka.
English: Prior to initiating treatment, clinicians should consider the safety profile of SEROQUEL XR (see Section
Slovenian: Pred uvedbo zdravljenja mora zdravnik upoštevati varnostne značilnosti zdravila Seroquel SR (glejte poglavje 4.4).
English: Such patients should have a WBC count and an absolute neutrophil count (ANC) performed promptly, especially in the absence of predisposing factors.
Slovenian: Takšnim bolnikom je treba takoj določiti število belih krvnih celic in absolutno število nevtrofilcev, zlasti če nimajo predispozicijskih dejavnikov.
English: 8 tablets
Slovenian: 8 tablet
English: Your tablets may make you feel sleepy.
Slovenian: Tablete Seroquel lahko povzročijo zaspanost.
English: In a study examining the effects of food on the bioavailability of quetiapine, a high-fat meal was found to produce statistically significant increases in the Seroquel XR Cmax and AUC of approximately 50% and 20% respectively., It cannot be excluded that the effect of a high fat meal on the formulation may be larger.
Slovenian: V študiji, ki je preučevala učinke hrane na biološko uporabnost kvetiapina, so odkrili, da zelo masten obrok povzroči statistično značilno povečanje Cmax in AUC zdravila Seroquel SR za približno 50 % oziroma 20 %.
English: Lipids:
Slovenian: Lipidi:
English: No information is available for Seroquel XR in children and adolescents.
Slovenian: O zdravilu Seroquel SR pri otrocih in mladostnikih ni informacij.
English: There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, or feeding disorder.
Slovenian: hipertoniji, hipotoniji, tremorju, zaspanosti, dihalni stiski in motnjah hranjenja.
English: Treatment with Seroquel was initiated at 50 mg/day and on day 2 increased to 100 mg/day; subsequently the dose was titrated to a target dose (mania 400-600 mg/day; schizophrenia 400-800 mg/day) using increments of 100 mg/day given two or three times daily.
Slovenian: Zdravljenje z zdravilom Seroquel so začeli s 50 mg na dan; odmerek so nato 2. dan povečali na 100 mg na dan, potem pa so odmerek titrirali do ciljnega odmerka (manija od 400 do 600 mg na dan, shizofrenija od 400 do 800 mg na dan) v korakih po 100 mg na dan in z uporabo dvakrat ali trikrat na dan.
English: 50 mg tablets are peach coloured; 150 mg tablets are white coloured, 200 mg tablets are yellow coloured; 300 mg tablets are pale yellow coloured and 400 mg tablets are white coloured.
Slovenian: 50 mg tablete so marelične barve; 150 mg tablete so bele barve; 200 mg tablete so rumene barve,