FrancophonIA/ELRC3.0 huggingface dataset:
English: Summary of thresholds for laboratory evaluations resulting in contra-indication or treatment modification (interruption, dose reduction or discontinuation)
Croatian: Sažetak graničnih vrijenosti laboratorijskih pretraga, procjena kojih dovodi do kontraindikacija ili promjena liječenja (prekid doziranja, smanjenje doze ili prestanak liječenja)
English: Severe renal toxicity may occur in dogs suffering from renal disorders at the start of treatment (including high blood creatinine level or proteinuria).
Croatian: Teška toksičnost za bubrege može se pojaviti na početku liječenja kod pasa koji pate od bubrežnih poremećaja (uključujući visoku razinu kreatinina u krvi ili proteinuriju).
English: Pharmacotherapeutic group: protein-tyrosine kinase inhibitor.
Croatian: Farmakoterapijska grupa: inhibitor protein-tirozin kinaze.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGE UNITS Label
Croatian: OSNOVNI DJELOVI NAPISANI NA MALIM JEDINICAMA UNUTARNJIH PAKOVANJA Oznaka
English: The tablets are available in pack sizes of 30 tablets.
Croatian: Tablete su dostupne u pakovanju od 30 tableta.
English: These dogs may be treated with either 50, 100 or 150 mg, if it is feasible to achieve a target dose of 11-14 mg/kg bw.
Croatian: Ovi psi mogu biti liječeni s 50, 100 ili 150 mg, ako je moguće postići ciljanu dozu 11-14 mg/kg tjelesne težine.
English: The recommended daily dose of 12.5 mg/kg body weight corresponds to the Maximum Tolerated Dose (MTD) that was derived from repeat dose toxicity studies in healthy Beagle dogs.
Croatian: Preporučena dnevna doza od 12.5 mg/kg tjelesne težine odgovara najvišoj podnošljivoj dozi (Maximum Tolerated Dose - MTD), koji je izvedena iz ponavljanih ispitivanja toksičnosti doze u zdravih Beagle pasa.
English: The active substance of Masivet can cause skin sensitisation.
Croatian: Djelatna tvar u Masivetu može izazvati preosjetljivost kože.
English: Hence, caution is advised with the concurrent use of masitinib and other substances.
Croatian: Dakle, oprez je potreban pri istovremenoj primjeni masitiniba i drugih tvari.
English: In dogs with a bodyweight of less than 15 kg, accurate dosing is not always possible.
Croatian: Kod pasa tjelesne težine manje od 15 kg, točno doziranje nije uvijek moguće.
English: Protein-loss syndrome (mainly due to a decrease in serum albumin).
Croatian: Sindrom gubitka bjelančevina (uglavnom zbog pada albumina u serumu).
English: The recommended dose is 12.5 mg/kg (with a dose range of 11-14 mg/kg) once daily as presented in the table below.
Croatian: Preporučena doza je 12.5 mg/kg (uz raspon doze od 11 - 14 mg/kg) jednom dnevno, kako je prikazano u tablici u nastavku.
English: Renal function should be adequately monitored every month using dipstick urine testing.
Croatian: Bubrežnu funkciju treba odgovarajuće pratiti svaki mjesec testiranjem mokraće s papirnom trakom (dipstick).
English: Treatment should be maintained in the case of stable disease, i.e. static, partial or complete tumour response, provided that the product is sufficiently well tolerated.
Croatian: Liječenje treba održavati u slučaju stabilne bolesti, odnosno kod statičnog, djelomičnog ili potpunog tumorskog odgovora, pod uvjetom da se proizvod dovoljno dobro podnosi.
English: Each tablet also contains Sunset yellow FCF (E 110) aluminium lake and Titanium dioxide (E171) as colourants.
Croatian: Svaka tableta također sadrži boje, naranđasto crveniFCF (E 110) aluminijev lak i titanij dioksid (E171).
English: In vitro tests with human microsomes demonstrate that concomitant treatment with substances which are metabolised by CYP450 isoforms may result in higher or lower plasma levels of either masitinib or those substances.
Croatian: In vitro ispitivanja s ljudskim mikrosomima pokazuju da istovremeno liječenja tvarima koja su metabolizirana izooblicima CYP450 mogu dovesti do viših ili nižih koncentracija masitiniba ili tih tvari u plazmi.
English: The active substance of Masivet can cause severe eye-irritation and serious damage to the eyes.
Croatian: Djelatna tvar u Masivetu može izazvati teški nadražaj i ozbiljno oštećenje očiju.
English: Tell your veterinarian about all medicines, including over-the-counter products, that you intend to administer to your dog.
Croatian: Recite vašem veterinaru o svim VMP koje namjeravate dati svome psu, uključujući one bez recepta.
English: Children should not have close contact to treated dogs, treated dog faeces or vomit.
Croatian: Djeca ne smiju biti u bliskom kontakt s liječenim psom, njegovim izmetom ili povraćenim sadržajem.
English: The recommended daily dose of 12.5 mg/kg body weight corresponds to the Maximum Tolerated Dose (MTD).
Croatian: Preporučena dnevna doza od 12.5 mg/kg tjelesne težine odgovara najvišoj podnošljivoj dozi (Maximum Tolerated Dose - MTD).
English: If the tablet is regurgitated or vomited later than 10 minutes following administration, treatment should not be repeated.
Croatian: Ako je tableta ispljunuta ili ispovraćana nakon više od 10 minuta nakon primjene, liječenje se ne smije ponoviti.
English: In dogs with a bodyweight of less than 15 kg accurate dosing is not always possible.
Croatian: U pasa tjelesne težine manje od 15 kg precizno doziranje nije uvijek moguće.
English: Concurrent use of substances which are metabolised by CYP450 isoforms may result in higher or lower plasma levels of either masitinib or those substances.
Croatian: Istodobna primjena tvari koje se metaboliziraju putem izooblika CYP450 može dovesti do viših ili nižih razina masitiniba ili tih tvari u plazmi
English: In dogs with nonresectable mast cell tumours, Grade 2 or 3, expressing a mutated tyrosine kinase c-kit receptor, treatment with Masivet showed a significantly longer Time-to-Tumour Progression (TTP) with a median of 241 days as compared to 83 days for placebo.
Croatian: U pasa s neoperabilnim tumorom mastocita, 2. ili 3. stupnja s izraženim mutiranim receptorom, tirozin kinaze c-kit, liječenje Masivetom je značajno produžilo vrijeme do progresije tumora (Time-to-Tumour Progression - TTP) uz središnju vrijednosti od 241 dana u odnosu na 83 dana za placebo.
English: In case of clinical signs of anaemia or haemolysis, haemoglobin, free bilirubin and haptoglobin should be measured and blood cell counts (including reticulocyte) should be performed.
Croatian: U slučaju kliničkih znakova anemije ili hemolize, treba mjeriti hemoglobin, slobodni bilirubin i haptoglobin, te izmjeriti broj krvnih stanica (uključujući i retikulocite).
English: Masitinib is a protein-tyrosine kinase inhibitor which, in vitro, potently and selectively inhibits the mutated form, in the juxtamembrane (JM) region, of the c-kit receptor.
Croatian: Masitinib je inhibitor protein-tirozin kinaze koji, in vitro, snažno i selektivno inhibira mutirani oblik ckit receptora u području jukstamembrane (JM).
English: Other commonly observed adverse reactions were in most cases mild or moderate: Lethargy and asthenia with a mean duration of approximately 8 and 40 days, respectively.
Croatian: Ostale najčešće uočene nuspojave bile su u većini slučajeva blage ili umjerene: Letargija i astenija s prosječnim trajanjem od oko 8, odnosno 40 dana.
English: In case of UPC ratio > 2 or albumin < 0.75 lower limit of normal (LLN), treatment should be interrupted until albumin and UPC values have returned to limit value (UPC ratio < 2 and albumin > 0.75 LLN), treatment can then be continued at the same dose.
Croatian: U slučaju da je omjer UPC > 2 ili albumin < 0.75 donje granice normale (DGN), liječenje treba prekinuti dok se albumin i UPC vrijednosti ne vrate u granične vrijednosti (omjer UPC < 2 i albumin > 0.75 DGN), zatim se liječenje može nastaviti u istoj dozi.
English: If the tablet is regurgitated or vomited within 10 minutes following administration, treatment should be repeated.
Croatian: Ako je tableta ispljunuta ili ispovraćana u roku od 10 minuta nakon primjene, liječenje treba ponoviti.
English: Do not use in dogs suffering from liver impairment, defined as AST or ALT > 3 x Upper Limit of Normal (ULN).
Croatian: Ne primjenjivatina psima koji imaju oštećenje jetre, određeno kao povišenje AST ili ALT > 3 x gornja granica normale (GGN).
English: The presence of a mutated tyrosine kinase c-kit receptor must be confirmed prior to treatment.
Croatian: Prisutnost mutiranog receptora tirozin kinaze c-kit mora biti potvrđena prije tretmana.
English: The presence of a mutated tyrosine kinase c-kit receptor must be confirmed prior to treatment (see also section 5.1).
Croatian: Prisutnost mutacije receptora c-kit tirozin kinaze mora biti potvrđena prije liječenja (vidjeti poglavlje 5.1).
English: Treatment should be permanently discontinued in case of renal toxicity, immune-mediated haemolytic anaemia (IMHA) and/or anaemia due to lack of regeneration, and if severe neutropenia, and/or severe diarrhoea and/or severe vomiting persist after dose reduction.
Croatian: Liječenje treba trajno prekinuti u slučaju intoksikacije bubrega, imunološki uvjetovane hemolitičke anemije (immune-mediated haemolytic anaemia - IMHA) i/ili anemije uzrokovane nedostatkom regeneracije, te ako teška neutropenija, i/ili teški proljev i/ili teško povraćanje ustraju nakon smanjenja doze.
English: Contra-indication
Croatian: KONTRAINDIKACIJE
English: If UPC ratio > 2, or creatinine > 1.5 upper limit of normal (ULN), or albumin < 0.75 lower limit of normal (LLN) or blood urea nitrogen (BUN) > 1.5 ULN, discontinue treatment.
Croatian: Ako je omjer UPC > 2, ili je kreatinin > 1.5 gornje granice normale (GGN), ili albumin < 0.75 donje granice normale (DGN) ili ureja u krvi (blood urea nitrogen - BUN) > 1.5 GGN, liječenje treba prekinuti.
English: In case of adverse events following overdose, treatment should be discontinued until resolution, and then resumed at the recommended therapeutic dose level.
Croatian: U slučaju nastajanja nuspojava radi predoziranja, liječenje treba prekinuti do prestanka istih, a potom nastaviti liječenje primjenom preporučene terapijske doze.
English: Dogs should be monitored carefully and professional judgement should be used to determine the need for dose reduction in the event of possible significant adverse reactions.
Croatian: Pse treba pažljivo nadzirati te na osnovi stručne procijene treba odlučiti potrebu za smanjenjem doze u slučaju mogućih značajnih nuspojava.
English: Repeated dermal contact with masitinib may impair female fertility and foetal development.
Croatian: Ponavljani kontakt masitiba s kožom može utjecati na plodnost ženki i razvoj ploda.
English: The treatment should be discontinued if any of these signs are observed: anaemia, severe neutropenia, severe renal toxicity, hepatic toxicity and/or severe diarrhoea or vomiting persistent after dose reduction.
Croatian: Liječenje treba prekinuti ako se primjeti bilo koji od ovih znakova: anemija, teška neutropenija, teška intoksikacija bubrega, intoksikacija jetre i/ili teški proljev ili povraćanje koji ne nestaju i nakon smanjenja doze.
English: Dogs should not be used for breeding while under treatment.
Croatian: Za vrijeme liječenja psi se nesmiju upotrebljavati za rasplod.
English: • If broken tablets, vomit, urine or faeces of treated dogs come into contact with the skin, rinse immediately with plenty of water.
Croatian: • Ukoliko slomljena tableta, povraćeni sadržaj, mokraća ili izmet dođu u kontakt s kožom, odmah isprati s puno vode.
English: Special precautions for use in animals: What are the special precautions for my dog?
Croatian: Koje su posebne mjere opreza za mog psa?
English: If a broken tablet is rejected by the dog after chewing, it should be disposed of.
Croatian: Ako pas ispljune dio tablete nakon žvakanja, taj dio treba baciti.
English: Each tablet contains either 50 mg or 150 mg of masitinib, which is the active substance.
Croatian: Svaka tableta sadrži 50 mg ili 150 mg djelatne tvari masitinib.
English: > 3 ULN
Croatian: > 3 GGN
English: Masivet is a prescription medicine used to treat dog mast cell tumours.
Croatian: Masivet je VMP koji se izdaje na recept koji se koristi za liječenje tumora mastocita u pasa.
English: 3 avenue George V 75008 Paris
Croatian: 3 avenue George V 75008 Pariz
English: Increase in aminotransferase (ALT or AST) with a mean duration of approximately 29 days.
Croatian: Porast aminotransferaze (ALT ili AST) s prosječnim trajanjem od oko 29 dana.
English: Haemoglobin < 10 g/dl and either free bilirubin > 1.5 ULN and haptoglobin < 0.1 g/dl or reticulocytes < 80,000/mm
Croatian: Hemoglobin < 10 g/dl i slobodni bilirubin > 1.5 GGN i haptoglobin< 0.1 g/dl ili retikulociti < 80.000/mm
English: Concurrent use of other substances with a high degree of protein binding may compete with masitinib binding and thus cause adverse effects.
Croatian: Istodobna primjena drugih tvari s visokim stupnjem vezivanja za bjelančevine može konkurirati vezivanjumasitiniba i tako izazvati nuspojave.
English: THE WORDS “FOR ANIMAL TREATMENT ONLY” AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, if applicable
Croatian: 13. RIJEČI “ SAMO ZA PRIMJENU NA ŽIVOTINJAMA ” I UVETI ILI OGRANIČENJA
English: The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Croatian: Na uputi o VMP se mora nalaziti naziv i adresa proizvođača odgovornog za puštanje dotične serije.
English: In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Croatian: U slučaju da se nehotice proguta odmah potražiti pomoć liječnika i pokažite mu uputu o VMP ili etiketu.
English: Lipoma (mean duration 53 days).
Croatian: Lipom (prosječno trajanje 53 dana).
English: BATCH NUMBER
Croatian: SERIJSKI BROJ
English: In the case of adverse reactions, doses might be reduced to once daily doses of 9 mg/kg bodyweight (range 7.5-10.5 mg/kg) or 6 mg/kg bw (range 4.5-7.5 mg/kg) according to the tables below.
Croatian: U slučaju nuspojava, doze se mogu smanjiti na jednodnevne doze od 9 mg/kg tjelesne težine (raspon 7.5 - 10.5 mg/kg) ili 6 mg/kg tjelesne težine (raspon 4.5 - 7.5mg/kg) prema tablicama u nastavku.
English: Treatment should be discontinued in case of: Haemolytic anaemia, i.e. haemoglobin < 10 g/dl and haemolysis, i.e. free bilirubin > 1.5 ULN and haptoglobin < 0.1 g/dl, Anaemia due to lack of regeneration, i.e. haemoglobin< 10 g/dl and reticulocytes < 80,000/mm
Croatian: Liječenje treba prekinuti u slučaju: hemolitičke anemije, tj. ako je hemoglobin < 10 g/dl, te hemolize, tj. ako je slobodni bilirubin > 1.5 GGN i haptoglobin < 0.1 g/dl, anemije uzrokovane nedostatkom regeneracije, tj. ako je hemoglobin < 10 g/dl i ako su retikulociti < 80.000/mm
English: Lymphadenopathy (mean duration 47 days).
Croatian: Limfadenopatija (prosječno trajanje 47 dana).
English: Decrease in appetite or anorexia with a mean duration of 45 days and 18 days, respectively.
Croatian: Smanjenje apetita ili anoreksija s prosječnim trajanjem od oko 45 dana, odnosno 18 dana.
English: ADVERSE REACTIONS Should I expect side effects for my dog during Masivet therapy?
Croatian: NUSPOJAVE Trebam li očekivati nuspojave u mog psa tijekom liječenja Masivetom?
English: In case of tumour progression, efficacy of treatment is unlikely to be successful and the treatment should be reviewed.
Croatian: U slučaju progresije tumora, učinkovitost liječenja nije izgledna, te liječenje treba preispitati.
English: Can other medications be given while my dog is taking Masivet?
Croatian: Mogu li se drugi VMP davati psu dok dobiva Masivet?
English: Mild to moderate hair loss with a mean duration of approximately 26 days.
Croatian: Blagi do umjereni gubitak dlake s prosječnim trajanjem od oko 26 dana.
English: 9 mg per kg bodyweight once daily as presented in the table below.
Croatian: 9 mg po kg tjelesne težine dnevno kao što je prikazano u donjoj tablici.
English: • Wear protective gloves while disposing of vomit, urine or faeces of treated dogs.
Croatian: • Nositi zaštitne rukavice kod rukovanja povraćenim sadržajem, mokraćom ili izmetom liječenih pasa.
English: In case of tumour progression, treatment is unlikely to be successful and the treatment should be reviewed.
Croatian: U slučaju progresije tumora, liječenje vjerojatno neće biti uspješno te ga treba preispitati.
English: Cough (mean duration 23 days).
Croatian: Kašalj (prosječno trajanje 23 dana).
English: Mild or moderate neutropenia with a mean duration of approximately 24 days.
Croatian: Blaga ili umjerena neutropenija s prosječnim trajanjem od oko 24 dana.
English: Albumin < 1 LLN or UPC > 2
Croatian: Albumin < 1 DGN ili UPC > 2
English: In case of positive semiquantitative dipstick results (protein > 30 mg/dl), urinalysis should be performed to determine urinary protein creatinine (UPC) ratio, and a blood sample to measure creatinine, albumin and BUN.
Croatian: U slučaju pozitivnih polukvantitativnih rezultata mjerenja papirnom trakom (bjelančevine > 30 mg/dl), treba provesti analizu mokraće kako bi se utvrdio omjer bjelančevina i kreatinina u mokraći (UPC), te uzeti uzorak krvi za mjerenje kreatinina, albumina i ureje u krvi.
English: Mild to moderate alopecia with a mean duration of approximately 26 days.
Croatian: Blaga do umjerena alopecija s prosječnim trajanjem od oko 26 dana.
English: Do not use in dogs suffering from renal function impairment, defined as Urinary Protein Creatinine (UPC) ratio > 2 or albumin < 1 x Lower Limit of Normal (LLN).
Croatian: Ne primjenjivati na psima koji koji imaju oštećenje bubrežne funkcije, definirano kao porast omjer bjelančevina i kreatinina u mokraći (Urinary Protein Creatinine - UPC ratio) > 2 ili pad albumina < 1
English: 6 mg per kg bodyweight once daily as presented in the table below.
Croatian: 6 mg po kg tjelesne težine dnevno kao što je prikazano u donjoj tablici.
English: Do not use in pregnant or lactating bitches.
Croatian: Ne primjenjivati u gravidnih kuja ili kuja u laktaciji.
English: At the second occurrence of the same event, treatment should be interrupted until resolution; treatment should then be continued with a reduced dose of 9 mg/kg bodyweight/day; At the third occurrence of the same event, treatment should be interrupted until resolution; treatment should then be continued with a dose further reduced to 6 mg/kg/day; Treatment should be discontinued, if severe adverse reactions are still encountered at the 6 mg/kg/day dose.
Croatian: Kod drugog pojavljivanja iste nuspojave, liječenje treba prekinuti do prestanka iste; liječenje treba nastaviti smanjenom dozom od 9 mg/kg tjelesne težine/dan;
English: • Avoid skin contact with faeces, urine, and vomit of treated dogs.
Croatian: • Izbjegavati kontakt kože sa izmetom, mokraćom i povraćenim sadržajem liječenih pasa.
English: Tablet coating:
Croatian: Obloga tablete:
English: Mild to moderate gastrointestinal reactions (diarrhoea and vomiting) with a mean duration of approximately 21 and 9 days, respectively.
Croatian: Blage do umjerene želučanocrijevne reakcije (proljev i povraćanje) s prosječnim trajanjem od oko 21 odnosno 9 dana.
English: Hepatic toxicity (ALT or AST elevation), neutropenia In case of an increase of ALT or AST > 3 ULN, decrease of neutrophil count < 2,000/mm or any other severe adverse events, treatment should be modified as follows: At the first occurrence, treatment should be interrupted until resolution, and then resumed at the same dose level;
Croatian: Intoksikacija jetre (porast ALT ili AST), neutropenija U slučaju povećanja ALT ili AST > 3 GGN, pada broja neutrofila < 2000/mm ili bilo koje druge teške nuspojave, liječenje treba izmijeniti kako slijedi:
English: Moderate to severe anaemia (aplastic/haemolytic) with a mean duration of approximately 7 days.
Croatian: Umjerena do teška anemija (aplastična/hemolitička) s prosječnim trajanjem od oko 7 dana.
English: • is less 6 months of age or weights less than 4 kg,
Croatian: • je mlađi od 6 mjeseci ili teži manje od 4 kg, pati od neadekvatne jetrene ili bubrežne funkcije
English: Monitoring of Protein loss syndrome Perform every month a dipstick urine test.
Croatian: Praćenje sindroma gubitka bjelančevina Svaki mjesec treba napraviti kontrolu mokraće testnom trakom.
English: Do not use in dogs with neutropenia defined as absolute neutrophil count < 2,000 /mm Do not use in case of hypersensitivity to the active substance or to any of the excipients.
Croatian: Ne primjenjivati napsima s neutropenijom ako je ukupni broj neutrofila < 2.000 /mm
English: AB Science S.A. 3 avenue George V FR-75008 Paris France
Croatian: AB Science S.A. 3 avenue George V FR-75008 Pariz Francuska
English: Treatment of non-resectable dog mast cell tumours (Grade 2 or 3) with confirmed mutated c-kit tyrosine kinase receptor.
Croatian: Liječenje neoperabilnog tumora mastocita u pasa (stupanj 2 ili 3) s potvrđenom mutacijom receptora c-kit tirozin kinaze.
English: In case of positive semi-quantitative dipstick results (protein ≥ 30 mg/dl), perform urinalysis to determine urinary protein creatinine (UPC) ratio.
Croatian: U slučaju pozitivnih rezultata testiranja s polukvantitativnim testnim trakama (bjelančevine ≥ 30 mg / dl), treba provesti analizu mokraće kako bi se utvrdio omjer bjelančevina i kreatinina u mokraći (UPC).
English: Manufacturer for batch release:
Croatian: Nositelj odobrenja za proizvodnju za puštanje proizvodne serije:
English: 60 ml bottle containing 30 Masivet 150 mg film-coated tablets.
Croatian: Bočica od 60 ml sadrži 30 Masivet filmom obloženih tableta od 150 mg.
English: 12.5 mg/kg bw Number of tablets per day
Croatian: 12.5 mg/kg tjelesne težine
English: 40 ml bottle containing 30 Masivet 50 mg film-coated tablets.
Croatian: Bočica od 40 ml sadrži 30 Masivet filmom obloženih tableta od 50 mg.
English: Masivet is for the treatment of dogs with non-resectable mast cell tumours (Grade 2 or 3) with a confirmed mutated c-kit tyrosine kinase receptor.
Croatian: Masivet se koristi za liječenje pasa s neoperabilnim tumorom mastocita ( stupanj 2 ili 3), s potvrđenim mutiranim receptorom tirozin kinaza c-kit.
English: Doses can be reduced to 9 mg/kg bodyweight (range 7.5-10.5 mg/kg) or 6 mg/kg bw (range 4.5-7.5 mg/kg) according to the tables below.
Croatian: 5 mg/kg) ili na 6 mg/kg tjelesne težine (raspon 4.5 - 7.5 mg/kg) u skladu s tablicama u nastavku.
English: Oedema (mean duration of oedema was 7 days).
Croatian: Edem (prosječno trajanje 7 dana).
English: 6 mg per kg bodyweight
Croatian: 6 mg po kg tjelesne težine
English: MASIVET 50 mg film-coated tablets for dogs MASIVET 150 mg film-coated tablets for dogs
Croatian: MASIVET 50 mg filmom obložene tablete za pse MASIVET 150 mg filmom obložene tablete za pse
English: Very common effects:
Croatian: Česti učinci
English: Albumin < 0.75 LLN or UPC > 2
Croatian: Albumin < 0.75 DGN ili UPC > 2 (2. put)
English: 9 mg per kg bodyweight
Croatian: 9 mg po kg tjelesne težine
English: Masitinib treatment should only be used in dogs with non-resectable mast cell tumours and which express the mutated c-kit tyrosine kinase receptor.
Croatian: Liječenje masitinibom treba koristiti samo u pasa s neoperabilnim tumorom mastocita i u onih s izraženom mutacijom receptora c-kit tirozin kinaze.
English: 6.2 Incompatibilities
Croatian: Nekompatibilnosti
English: Management of Haemolytic and aregenerative Anaemia (haemoglobin, bilirubin, haptoglobin, reticulocytes)
Croatian: (hemoglobin, bilirubin, haptoglobin, retikulociti) Kontraindikacija Prekid doziranja Smanjenje doze
English: • is pregnant or nursing puppies,
Croatian: • je skotna ili doji,
English: MASIVET 50 mg film-coated tablets for dogs Masitinib
Croatian: MASIVET 50 mg filmom obložena tableta za pse Masitinib
English: PACKAGE LEAFLET MASIVET 50 mg film-coated tablets for dogs MASIVET 150 mg film-coated tablets for dogs
Croatian: UPUTA O VMP MASIVET 50 mg filmom obložene tablete za pse MASIVET 150 mg filmom obložene tablete za pse
English: MASIVET 150 mg film-coated tablets for dogs Masitinib
Croatian: MASIVET 150 mg filmom obložene tablete za pse Masitinib
English: EXPIRY DATE
Croatian: DATUM ISTEKA VALJANOSTI
English: CONTENTS
Croatian: SADRŽAJ
English: < 2,000/mm st time)
Croatian: < 2.000/mm (4. put)