FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients receiving Atripla or any other antiretroviral therapy may continue to develop opportunistic infections and other complications of HIV infection, and therefore should remain under close clinical observation by physicians experienced in the treatment of patients with HIV associated diseases.
Slovenian: Pri bolnikih, ki prejemajo zdravilo Atripla ali katerokoli drugo protiretrovirusno zdravljenje, se lahko še naprej pojavljajo oportunistične okužbe in drugi zapleti okužbe z virusom HIV, zato morajo ostati pod skrbnim nadzorom zdravnikov z izkušnjami pri zdravljenju bolnikov z boleznimi, povezanimi s HIV.
English: In children whose mothers took NRTIs during pregnancy, the benefit from the protection against HIV outweighed the risk of side effects.
Slovenian: Pri otrocih, katerih matere so med nosečnostjo jemale nukleozidne zaviralce reverzne transkriptaze (NRTI, nucleoside reverse transcriptase inhibitors), je korist zaščite pred virusom HIV odtehtala tveganje za neželene učinke.
English: Combination of emtricitabine and tenofovir disoproxil: Genotoxicity and repeated-dose toxicity studies of one month or less with the combination of these two components found no exacerbation of toxicological effects compared to studies with the separate components.
Slovenian: Kombinacija emtricitabina in dizoproksiltenofovirata: Študije genotoksičnosti in toksičnosti pri ponavljajočih se odmerkih, ki so trajale en mesec ali manj pri kombinaciji teh dveh učinkovin, niso pokazale poslabšanja toksikoloških učinkov v primerjavi s študijami posameznih učinkovin.
English: The net effect of co-administration is not clear.
Slovenian: Neto učinek sočasne uporabe ni razjasnjen.
English: Atripla should be taken on an empty stomach (commonly defined as 1 hour before or 2 hours after a meal) preferably at bedtime.
Slovenian: Zdravilo Atripla morate jemati na prazen želodec (kar pomeni 1 uro pred ali 2 uri po obroku), najbolje zvečer pred spanjem.
English: Please refer to the Summary of Product Characteristics for these medicinal products.
Slovenian: Prosimo, glejte Povzetke glavnih značilnosti teh posameznih zdravil.
English: Total active HMG Co-A reductase inhibitors:
Slovenian: Skupni aktivni zaviralci HMG Co-A reduktaze:
English: If this is unavoidable, your doctor will monitor your kidney function once a week.
Slovenian: Če se sočasnemu jemanju ni mogoče izogniti, bo vaš zdravnik enkrat tedensko preverjal delovanje ledvic.
English: Patients either changed to Atripla (N=203) or continued on their original antiretroviral treatment regimen (N=97).
Slovenian: Bolniki so zamenjali zdravljenje in začeli prejemati zdravilo Atripla (N=203) ali pa so nadaljevali prvotno protiretrovirusno zdravljenje (N = 97).
English: These side effects may start in the first 1 or 2 days of treatment and usually go away after the first 2 to 4 weeks.
Slovenian: Ti neželeni učinki se lahko pojavijo v prvem dnevu ali prvih dveh dneh zdravljenja in navadno izginejo po prvih dveh do štirih tednih.
English: The potential for interactions with efavirenz and other azole antifungals, such as ketoconazole, has not been studied.
Slovenian: Možnosti interakcij efavirenza in drugih azolskih antimikotikov, kot je ketokonazol, niso raziskovali.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
Slovenian: Pri sočasnem protivirusnem zdravljenju hepatitisa B ali C glejte ustrezne Povzetke glavnih značilnosti teh zdravil.
English: Findings in the rat and monkey studies indicated that there was a substance-related decrease in intestinal absorption of phosphate with potential secondary reduction in BMD.
Slovenian: Ugotovitve pri študijah na podganah in opicah kažejo, da je prišlo do z učinkovino povezanega zmanjšanja črevesne absorpcije fosfata s potencialnim sekundarnim zmanjšanjem BMD.
English: Because of the long half-life of efavirenz, use of adequate contraceptive measures for 12 weeks after discontinuation of Atripla is recommended.
Slovenian: Zaradi dolgega razpolovnega časa efavirenza priporočamo uporabo ustrezne kontracepcije še 12 tednov po prekinitvi zdravljenja z zdravilom Atripla.
English: The mean plasma to blood concentration ratio was approximately 1.0 and the mean semen to plasma concentration ratio was approximately 4.0.
Slovenian: Povprečje razmerja koncentracije v plazmi in krvi je bilo približno 1,0, razmerje koncentracije v spermi in plazmi pa približno 4,0.
English: Use of Atripla in combination with saquinavir as the sole protease inhibitor is not recommended.
Slovenian: Uporaba zdravila Atripla v kombinaciji s sakvinavirjem kot edinim zaviralcem proteaze ni priporočljiva.
English: Approximately 14 to 34% of a radiolabelled dose of efavirenz was recovered in the urine and less than 1% of the dose was excreted in urine as unchanged efavirenz.
Slovenian: Približno 14-34 % radioaktivno označenega odmerka efavirenza se je izločilo z urinom, manj kot 1 % odmerka pa se je z urinom izločilo v obliki nespremenjenega efavirenza.
English: However, in some patients, declines in creatinine clearance did not completely resolve despite tenofovir disoproxil discontinuation.
Slovenian: Vendar pa pri nekaterih bolnikih upad očistka kreatinina ni povsem izzvenel, kljub prekinitvi dizoproksiltenofovirata.
English: Atripla is not usually taken with other medicines that can damage your kidneys (see Other medicines and Atripla).
Slovenian: Zdravilo Atripla se po navadi ne jemlje skupaj z drugimi zdravili, ki lahko škodijo ledvicam (glejte Druga zdravila in zdravilo Atripla).
English: Use of Atripla should be avoided with concurrent or recent use of a nephrotoxic medicinal product.
Slovenian: Uporabi zdravila Atripla se je treba izogibati pri sočasni ali nedavni uporabi nefrotoksičnih zdravil.
English: Norelgestromin (active metabolite):
Slovenian: norelgestromin (aktivni presnovek):
English: Efavirenz may be an inducer of CYP2C19 and CYP2C9; however, inhibition has also been observed in vitro and the net effect of co-administration with substrates of these enzymes is not clear (see section 5.2).
Slovenian: Efavirenz je morda induktor encimov CYP2C19 in CYP2C9; vendar so in vitro opazili tudi zaviranje in neto učinek sočasne uporabe s substrati teh encimov ni razjasnjen (glejte poglavje 5.2).
English: Data are available from 286 patients who switched to Atripla: 160 had previously received efavirenz, emtricitabine and tenofovir disoproxil, and 126 had previously received Combivir and efavirenz.
Slovenian: Na voljo so podatki o 286 bolnikih, ki so prešli na zdravilo Atripla: 160 jih je predhodno prejemalo efavirenz, emtricitabin in dizoproksiltenofovirat, 126 pa zdravilo Combivir ter efavirenz.
English: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki jemljejo kombinirano protiretrovirusno zdravljenje, se lahko pojavi bolezen kosti, imenovana osteonekroza (smrt kostnega tkiva zaradi slabše prekrvavitve v kosteh).
English: Modified LOCF: Post-hoc analysis where patients who failed virologically or discontinued for adverse events were treated as failures; for other drop-outs, the LOCF (last observation carried forward) method was applied
Slovenian: Prilagojeni LOCF: Post-hoc analiza pri kateri so bili bolniki z virusnim neodzivom in bolniki pri katerih je bilo zdravljenje prekinjeno zaradi pojava neželenih učinkov obravnavani kot neuspeh; pri ostalih izključenih bolnikih pa je bila uporabljena metoda LOCF (last observation carried forward).
English: Emtricitabine (n=45)
Slovenian: emtricitabin (n = 45)
English: This loss is due to significant decreases in elbasvir/grazoprevir plasma concentrations caused by CYP3A4 or P-gp induction.
Slovenian: Ta izguba je posledica pomembnega zmanjšanja koncentracij elbasvirja/grazoprevirja v plazmi, ki jih povzroči indukcija CYP3A4 ali P-gp.
English: Exposures of raltegravir (a UGT1A1 substrate) are reduced in the presence of efavirenz (see section 4.5, Table 1).
Slovenian: Izpostavljenost raltegravirju (substratu UGT1A1) se v prisotnosti efavirenza zmanjša (glejte poglavje 4.5, Tabela 1).
English: The bone toxicity in young adult rats and dogs occurred at exposures ≥ 5-fold the exposure in paediatric or adult patients; bone toxicity occurred in juvenile infected monkeys at very high exposures following subcutaneous dosing (≥ 40-fold the exposure in patients).
Slovenian: Kostna toksičnost pri mladih odraslih podganah in psih se je pojavila pri izpostavljenostih, ki so bile ≥ 5-krat večje od izpostavljenosti pri pediatričnih ali odraslih bolnikih, kostna toksičnost pa se je pojavila pri mladih okuženih opicah pri zelo visokih izpostavljenostih po subkutanem odmerjanju (≥ 40-kratna izpostavitev pri bolnikih).
English: Most cases occurred in patients who already had liver disease, but there have been a few reports in patients without any existing liver disease
Slovenian: Ta učinek se je pojavil večinoma pri bolnikih z obstoječo jetrno boleznijo, vendar pa obstaja nekaj poročil o pojavu pri bolnikih, ki prej niso imeli jetrne bolezni;
English: The frequency category was estimated from a statistical calculation based on the total number of patients treated with efavirenz in clinical trials (n = 3,969) or exposed to emtricitabine in randomised controlled clinical trials (n = 1,563) or exposed to tenofovir disoproxil in randomised controlled clinical trials and the expanded access programme (n = 7,319).
Slovenian: Kategorija pogostnosti je bila ocenjena s pomočjo statističnega izračuna na podlagi skupnega števila bolnikov, zdravljenih z efavirenzom v kliničnih preskušanjih (n = 3.969) ali izpostavljenih emtricitabinu v randomiziranih kontroliranih kliničnih preskušanjih (n = 1.563) ali izpostavljenih dizoproksiltenofoviratu v randomiziranih kontroliranih kliničnih preskušanjih v razširjenjem programu dostopa (n = 7.319).
English: Each of these active substances, also known as antiretroviral medicines, work by interfering with an enzyme (reverse transcriptase) that is essential for the virus to multiply.
Slovenian: Vsaka od teh učinkovin, znanih kot protiretrovirusna zdravila, zavira encim (reverzno transkriptazo), ki je nujen za razmnoževanje virusa.
English: Atripla has not been evaluated in the presence of food.
Slovenian: Zdravila Atripla v prisotnosti hrane niso ocenjevali.
English: Following oral administration, the elimination half-life of tenofovir is approximately 12 to 18 hours.
Slovenian: Po peroralni uporabi je razpolovni čas izločanja tenofovirja približno 12 do 18 ur.
English: Severe rash associated with blistering, moist desquamation or ulceration has been reported in less than 1% of patients treated with efavirenz (see section 4.8).
Slovenian: O hudem izpuščaju, ki ga spremljajo mehurji, vlažna deskvamacija ali ulceracija, so poročali pri manj kot 1 % bolnikov, zdravljenih z efavirenzom (glejte poglavje 4.8).
English: - if you have a heart condition, such as an abnormal electrical signal called prolongation of the QT interval that puts you at high risk for severe heart rhythm problems (Torsade de Pointes).
Slovenian: - če imate bolezen srca, kot je nenormalen električni signal, kar se imenuje podaljšanje intervala QT, zaradi česar imate večje tveganje za hude težave s srčnim ritmom (torsade de pointes).
English: Emtricitabine is rapidly absorbed with peak plasma concentrations occurring at 1 to 2 hours post-dose.
Slovenian: Emtricitabin se hitro absorbira, največje koncentracije v plazmi pa so dosežene v 1 do 2 urah po zaužitju odmerka.
English: Voxilaprevir:↓
Slovenian: Pričakovano: voksilaprevir:↓
English: Thirteen percent of the emtricitabine dose was recovered in urine as three metabolites.
Slovenian: 13 % odmerka emtricitabina so odkrili v urinu v obliki treh presnovkov.
English: Appropriate antihistamines and/or corticosteroids may improve tolerability and hasten the resolution of rash.
Slovenian: Ustrezni antihistaminiki in/ali kortikosteroidi lahko izboljšajo prenosljivost in pospešijo izginotje izpuščaja.
English: High density polyethylene (HDPE) bottle with a polypropylene child-resistant closure containing 30 film-coated tablets and silica gel desiccant.
Slovenian: Steklenica iz polietilena velike gostote (HDPE) s polipropilensko za otroke varno zaporko, ki vsebuje 30 filmsko obloženih tablet in sušilo iz silikagela.
English: Clinically significant interactions are not expected as simeprevir and emtricitabine are eliminated via different pathways.
Slovenian: Klinično pomembnih interakcij ni pričakovati, saj se simeprevir in emtricitabin izločata po različnih poteh.
English: Following intravenous administration the volume of distribution of tenofovir was approximately 800 ml/kg.
Slovenian: Po intravenskem odmerku je volumen porazdelitve tenofovirja znašal približno 800 ml/kg.
English: - Medicines used to treat bacterial infections, including tuberculosis and AIDS-related mycobacterium avium complex: Clarithromycin, rifabutin, rifampicin.
Slovenian: - Zdravila za zdravljenje bakterijskih okužb, vključno s tuberkulozo in z AIDS-om povezanim kompleksom Mycobacterium avium: Klaritromicin, rifabutin, rifampicin.
English: If you forget to take Atripla
Slovenian: Če ste pozabili vzeti zdravilo Atripla
English: What Atripla is and what it is used for What you need to know before you take Atripla How to take Atripla
Slovenian: Kaj je zdravilo Atripla in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Atripla Kako jemati zdravilo Atripla Možni neželeni učinki
English: Darunavir/ritonavir should be used with caution in combination with Atripla.
Slovenian: Darunavir/ritonavir je treba v kombinaciji z zdravilom Atripla uporabljati previdno.
English: This decrease in atazanavir Cmin might negatively impact the efficacy of atazanavir.
Slovenian: Upad Cmin atazanavirja lahko negativno vpliva na njegovo učinkovitost.
English: Patients co-infected with HIV and HBV who discontinue Atripla must be closely monitored with both clinical and laboratory follow-up for at least four months after stopping treatment with Atripla.
Slovenian: Bolnike s sočasno okužbo s HIV in HBV, ki prekinejo zdravljenje z zdravilom Atripla, je treba skrbno nadzorovati s kliničnim in laboratorijskim sledenjem vsaj še štiri mesece po prekinitvi zdravljenja z zdravilom Atripla.
English: Genotoxicity studies revealed positive results in the in vitro mouse lymphoma assay, equivocal results in one of the strains used in the Ames test, and weakly positive results in an UDS test in primary rat hepatocytes.
Slovenian: Študije genotoksičnosti so pokazale pozitivne rezultate pri testu mišjega limfoma in vitro, dvoumne rezultate pri enem od sevov, ki so ga uporabili pri Amesovem testu, in rahlo pozitivne rezultate pri testu UDS pri primarnih podganjih hepatocitih.
English: Adverse reactions associated with the use of Atripla: Treatment-emergent adverse reactions considered possibly or probably related to Atripla reported in study AI266073 (over 48 weeks; n = 203), which have not been associated with one of the individual components of Atripla, include:
Slovenian: Neželeni učinki, povezani z uporabo zdravila Atripla: Neželene reakcije, ki so se pojavile pri zdravljenju in so morda ali verjetno povezane z zdravilom Atripla, o katerih so poročali v študiji AI266073 (več kot 48 tednov; n = 203), ki niso bile povezane s katero od posameznih sestavin zdravila Atripla, vključujejo:
English: Carcinogenicity studies in male mice, male and female rats were negative.
Slovenian: Študije kancerogenosti pri mišjih samcih, podganjih samcih in samicah so bile negativne.
English: Severe hepatic impairment (CPT, Class C) (see section 5.2).
Slovenian: Huda jetrna okvara (razreda C po lestvici CPT) (glejte poglavje 5.2).
English: Compared to fasted administration, dosing of tenofovir disoproxil and emtricitabine in combination with either a high fat meal or a light meal increased the mean AUC of tenofovir by 43.6% and 40.5%, and Cmax by 16% and 13.5%, respectively without affecting emtricitabine exposures.
Slovenian: V primerjavi z uporabo na tešče je odmerjanje dizoproksiltenofoviratain emtricitabina v kombinaciji z obrokom z veliko količino maščob ali z lahkim obrokom povečalo povprečno vrednost AUC tenofovirja za 43,6 % oziroma 40,5 %, vrednost Cmax tenofovirja pa za 16 % oziroma 13,5 %, pri čemer se izpostavljenost emtricitabinu ni spremenila.
English: Uncommon: - dry mouth - incoherent speech - increased appetite - libido decreased - myalgia
Slovenian: Občasni: - suha usta, - nepovezano govorjenje, - povečan apetit, - zmanjšanje spolne sle, - mialgija.
English: Resistance analysis by week 144 On-therapy genotypes Efavirenz resistance1 K103N K101E G190A/S Y188C/H V108I P225H M184V/I K65R K70E TAMs2
Slovenian: K103N K101E G109A/S Y188C/H V108I P225H M184V/I K65R K70E TAM2
English: Emtricitabine triphosphate and tenofovir diphosphate competitively inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.
Slovenian: Emtricitabintrifosfat in tenofovirdifosfat kompetitivno zavirata reverzno transkriptazo HIV-1, kar povzroči terminacijo verige DNA.
English: The following side effects may be signs of lactic acidosis: - deep rapid breathing - drowsiness - feeling sick (nausea), being sick (vomiting) and stomach pain.
Slovenian: Naslednji neželeni učinki so lahko znak laktacidoze: - globoko, hitro dihanje; - dremavost; - siljenje na bruhanje (slabost), bruhanje in bolečina v želodcu.
English: Patients with HIV-1 harbouring mutations
Slovenian: Bolniki z mutacijami virusa HIV-1
English: Post-marketing reports of hepatic failure also occurred in patients with no pre-existing hepatic disease or other identifiable risk factors (see section 4.8).
Slovenian: Iz obdobja po začetku trženja obstajajo poročila o jetrni odpovedi, ki se je pojavila pri bolnikih brez predhodno obstoječe bolezni jeter ali drugih opredeljivih dejavnikov tveganja (glejte poglavje 4.8).
English: The inducing effect of St. John's wort may persist for at least 2 weeks after cessation of treatment (see section 4.3).
Slovenian: Induktivni učinek šentjanževke lahko traja vsaj še 2 tedna po prekinitvi zdravljenja (glejte poglavje 4.3).
English: Psychiatric disorders: Common depression (severe in 1.6%)3, anxiety3, abnormal dreams3, insomnia3
Slovenian: Psihiatrične motnje: Pogosti depresija (huda v 1,6 %)3, anksioznost3, nenavadne sanje3, nespečnost3
English: One patient experienced involuntary muscle contractions.
Slovenian: Pri enem bolniku se je pojavilo nenadzorovano krčenje mišic.
English: Phenytoin, Phenobarbital, and other anticonvulsants that are substrates of CYP isozymes
Slovenian: fenitoin, fenobarbital in drugi antikonvulzivi, ki so substrati izocimov CYP
English: - Hormonal contraceptive, such as birth control pills, an injected contraceptive (for example, Depo-Provera), or a contraceptive implant (for example, Implanon): You must also use a reliable barrier method of contraception (see Pregnancy and breast-feeding).
Slovenian: - Hormonski kontraceptiv, na primer kontracepcijske tablete, injiciran kontraceptiv (na primer Depo-Provera) ali kontracepcijski vsadek (na primer Implanon): Uporabljati morate tudi zanesljivo mehansko kontracepcijo (glejte poglavje Nosečnost in dojenje).
English: Malformations have been observed in foetuses from efavirenz-treated monkeys (see section 5.3).
Slovenian: Malformacije so bile ugotovljene pri plodovih opic, zdravljenih z efavirenzom (glejte poglavje 5.3).
English: Efavirenz significantly decreases voriconazole plasma concentrations while voriconazole also significantly increases efavirenz plasma concentrations.
Slovenian: Efavirenz pomembno zmanjša koncentracijo vorikonazola v plazmi, vorikonazol pa sočasno pomembno poveča koncentracijo efavirenza v plazmi.
English: Resistance to efavirenz can be selected in vitro and resulted in single or multiple amino acid substitutions in HIV-1 RT, including L100I, V108I, V179D, and Y181C.
Slovenian: Odpornost proti efavirenzu se lahko pojavi in vitro in povzroči enkratne ali večkratne substitucije aminokislin v RT virusa HIV-1, vključno z L100I, V108I, V179D in Y181C.
English: Atazanavir/ritonavir: Insufficient data are available to make a dosing recommendation for atazanavir/ritonavir in combination with Atripla.
Slovenian: Atazanavir/ritonavir: Na voljo ni dovolj podatkov, da bi lahko izdelali priporočilo za odmerjanje atazanavirja/ritonavirja v kombinaciji z zdravilom Atripla.
English: Table 4: 48-week efficacy data from study AI266073 in which Atripla was administered to virologically suppressed patients on combination antiretroviral therapy
Slovenian: Tabela 4: Podatki učinkovitosti po 48 tednih iz študije AI266073, v kateri so zdravilo Atripla dajali bolnikom z virološko supresijo, ki so prejemali kombinirano protiretrovirusno zdravljenje
English: • softening of the bones (with bone pain and sometimes resulting in fractures) which may occur due to damage to the kidney tubule cells
Slovenian: • mehčanje kosti (z bolečino v kosteh in včasih zlomi), ki se lahko pojavi zaradi poškodbe celic ledvičnih tubulov;
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy (CART) and should be monitored according to standard practice.
Slovenian: Pri bolnikih z obstoječo motnjo delovanja jeter, vključno s kroničnim aktivnim hepatitisom, je pogostnost nepravilnosti v delovanju jeter med kombiniranim protiretrovirusnim zdravljenjem (CART - combination antiretroviral therapy) večja, zato jih je treba spremljati skladno s standardno prakso.
English: These patients should be carefully monitored for efavirenz adverse reactions, especially nervous system symptoms.
Slovenian: Pri teh bolnikih je treba pozorno spremljati neželene učinke efavirenza, zlasti simptome v živčevju.
English: See ritonavir row below.
Slovenian: Glejte vrstico o ritonavirju v tabeli spodaj.
English: Atripla comes in bottles of 30 tablets (with a silica gel sachet that must be kept in the bottle to help protect your tablets).
Slovenian: Zdravilo Atripla je na voljo v plastičnih vsebnikih po 30 tablet (z vrečko s silikagelom, ki jo morate hraniti v vsebniku za zaščito tablet).
English: Reproductive toxicity studies in rats and rabbits showed no effects on mating, fertility, pregnancy or foetal parameters.
Slovenian: Študije vpliva na sposobnost razmnoževanja pri podganah in kuncih niso pokazale učinka na parametre parjenje, plodnosti, nosečnost ali zarodka.
English: GS-3310071:
Slovenian: GS-3310071: AUC: ↔
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Slovenian: Zdravljenje mora začeti zdravnik z izkušnjami pri obravnavanju okužb z virusom HIV.
English: - Sertraline, a medicine used to treat depression, as your doctor may need to change your dose of sertraline.
Slovenian: - Sertralin, zdravilo, ki se uporablja za zdravljenje depresije: Zdravnik vam bo morda moral spremeniti odmerek sertralina.
English: Rare renal failure (acute and chronic), acute tubular necrosis, nephritis (including acute interstitial nephritis)4, nephrogenic diabetes insipidus
Slovenian: Redki ledvična odpoved (akutna in kronična), akutna tubularna nekroza, nefritis, (vključno z akutnim intersticijskim nefritisom)5, nefrogeni diabetes insipidus
English: The systemic clearance of emtricitabine averaged 307 ml/min.
Slovenian: Sistemski očistek emtricitabina je v povprečju 307 ml/min.
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to CART.
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV in/ali dolgotrajno izpostavljenostjo zdravljenju CART.