FrancophonIA/ELRC3.0 huggingface dataset:
English: North Harrow, Middlesex HA1 4HF United Kingdom
Danish: North Harrow, Middx HA1 4HF Storbritannien
English: Contains sunset yellow (E110).
Danish: Indeholder Sunset Yellow (E110).
English: The active ingredient is levetiracetam.
Danish: Det aktive stof er levetiracetam.
English: Do not take macrogol (a drug used as laxative) for one hour before and one hour after taking levetiracetam as this may results in a loss of its effect.
Danish: Tag ikke macrogol (et lægemiddel, der anvendes som afføringsmiddel) en time før og en time efter levetiracetam, da dette kan medføre tab af levetiracetams virkning.
English: Therefore a 50 % reduction of the daily maintenance dose is recommended when the creatinine clearance is < 60 ml/min/1.73m2.
Danish: Derfor anbefales en reduktion på 50 % af den daglige vedligeholdelsesdosis, når kreatininclearance er <60 ml/min/1,73 m2.
English: (monotherapy).
Danish: (monoterapi).
English: Due to its complete and linear absorption, plasma levels can be predicted from the oral dose of levetiracetam expressed as mg /kg bodyweight.
Danish: På grund af fuldstændig og lineær absorption kan plasmaniveauerne forudsiges ud fra oral levetiracetam-dosis udtrykt som mg/kg legemsvægt.
English: Croscarmellose Sodium Povidone K-30
Danish: Croscarmellosenatrium Povidone K-30
English: Should your doctor decide to stop your Levetiracetam Accord treatment, he/she will instruct you about the gradual withdrawal of Levetiracetam Accord.
Danish: Hvis lægen beslutter at stoppe Deres behandling med Levetiracetam Accord, vil han/hun instruere Dem i, hvordan De gradvist skal ophøre med at tage Levetiracetam Accord.
English: Therefore, patients should be monitored for signs of depression and/or suicidal ideation and behaviours and appropriate treatment should be considered.
Danish: Derfor bør patienterne overvåges for, om de får tegn på depression og/eller selvmordstanker ogadfærd, og passende behandling bør overvejes.
English: As in adults, there is no evidence of clinically significant medicinal product interactions in paediatric patients receiving up to 60 mg /kg/day levetiracetam.
Danish: Som for voksne er der ikke nogen evidens for klinisk signifikante lægemiddelinteraktioner hos pædiatriske patienter, som fik op til 60 mg/kg levetiracetam pr. dag.
English: Marketing authorization holder and manufacturer Marketing authorization holder Accord Healthcare S.L.U.
Danish: Indehaver af markedsføringstilladelsen og fremstiller Indehaver af markedsføringstilladelsen Accord Healthcare S.L.U.
English: Adverse reactions reported in clinical studies (adults, adolescents, children and infants> 1 month) and from post-marketing experience are listed in the following table per System Organ Class and per frequency.
Danish: Bivirkninger rapporteret fra kliniske studier (voksne, unge, børn og spædbørn >1 måned) og efter markedsføring er angivet i nedenstående tabel i henhold til systemorganklasse og hyppighed.
English: When you will first start taking Levetiracetam Accord, your doctor will prescribe you a lower dose (500 mg each day) during 2 weeks before giving you the lowest general dose of 1000 mg.
Danish: Når De begynder at tage Levetiracetam Accord, vil Deres læge ordinere en lavere dosis (500 mg daglig) i 2 uger, før De får den laveste vedligeholdelsesdosis (1000 mg).
English: What Levetiracetam Accord contains:
Danish: Levetiracetam Accord indeholder:
English: Dose and frequency(1) Infants 1 to less than 6 months
Danish: Dosis og hyppighed (1) Spædbørn fra 1 måned til under 6 måneder
English: Prevalence is significantly higher in Japanese patients when compared to nonJapanese patients.
Danish: Forekomsten er betydeligt højere hos patienter af japansk afstamning i forhold til patienter af ikke-japansk afstamning.
English: The pharmacokinetic results indicated that half-life was shorter (5.3 h) than for adults (7.2 h) and apparent clearance was faster (1.5 ml/min/kg) than for adults (0.96 ml/min/kg).
Danish: Farmakokinetiske resultater indikerer, at halveringstiden var kortere (5,3 timer) end for voksne (7,2 timer), og tilsyneladende clearance var hurtigere (1,5 ml/min/kg) end hos voksne (0,96 ml/min/kg).
English: Results related to behavioural and emotional functioning indicated a worsening in levetiracetam treated patients on aggressive behaviuor as measured in a standardised and systematic way using a validated instrument (CBCL - Achenbach Child Behavior Checklist).
Danish: Resultater relateret til adfærds- og følelsesmæssig funktion indikerede en forværring af aggressiv adfærd hos patienter behandlet med levetiracetam, vurderet på en standardiseret og systematisk måde ved brug af et valideret værktøj (CBLCAchenbach Child Behavior Checklist).
English: The plasma half-life in adults was 7±1 hours and did not vary either with dose, route of administration or repeated administration.
Danish: Halveringstiden for levetiracetam hos voksne var 71 timer og påvirkedes hverken af dosis, administrationsvej eller gentagen dosering.
English: Suicide, suicide attempt, suicidal ideation and behaviour have been reported in patients treated with anti-epileptic agents including levetiracetam.
Danish: Selvmord, selvmordsforsøg, selvmordstanker og -adfærd er rapporteret hos patienter i behandling med antiepileptika, inklusive levetiracetam.
English: Levetiracetam Accord is an antiepileptic medicine (a medicine used to treat seizures in epilepsy).
Danish: Levetiracetam Accord er et lægemiddel mod epilepsi (et lægemiddel, som anvendes til behandling af epileptiske anfald).
English: Neither levetiracetam nor its primary metabolite are significantly bound to plasma proteins (< 10 %).
Danish: Hverken levetiracetam eller den primære metabolit bindes i signifikant grad til plasmaproteiner (10
English: Colloidal anhydrous silica Magnesium Stearate (E470b)
Danish: Vandfri kolloid silica Magnesiumstearat (E470b)
English: PVC/Alu blister pack:
Danish: PVC/aluminium-blisterpakning:
English: The primary measure of effectiveness was the responder rate (percent of patients with ≥ 50% reduction from baseline in average daily partial onset seizure frequency) assessed by a blinded central reader using a 48-hour video EEG.
Danish: Det primære mål for effektivitet var responsraten (procent af patienter med ≥ 50 % reduktion i frekvensen af daglige partielle anfald i forhold til baseline) vurderet af en centralt blindet læser ved brug af 48 timers video -EEG.
English: Levetiracetam oral solution is the preferred formulation for use in this population.
Danish: Levetiracetam oral opløsning bør foretrækkes til denne population.
English: Your doctor will prescribe the most appropriate pharmaceutical form of levetiracetam according to the age, weight and dose.
Danish: Deres læge vil ordinere den mest hensigtsmæssige lægemiddelform af Levetiracetam Accord afhængigt af alder, vægt og dosis.
English: The active substance, levetiracetam, is a pyrrolidone derivative (S-enantiomer of α-ethyl-2-oxo-1-pyrrolidine acetamide), chemically unrelated to existing antiepileptic active substances.
Danish: Det aktive stof, levetiracetam er et pyrrolidon derivat (S-enantiomer af -ethyl-2-oxo-1-pyrrolidin acetamid), og er kemisk set ikke beslægtet med kendte antiepileptisk aktive stoffer.
English: Creatinine clearance (ml/min/1.73m2)
Danish: Kreatininclearance (ml/min/1,73 m2)
English: 500 to 1, 500 mg twice daily 500 to 1,000 mg twice daily 250 to 750 mg twice daily 250 to 500 mg twice daily 500 to 1,000 mg once daily (2)
Danish: 500 til 1.500 mg to gange dagligt 500 til 1.000 mg to gange dagligt 250 til 750 mg to gange dagligt 250 til 500 mg to gange dagligt 500 til 1.000 mg en gang dagligt (2)
English: Pharmacotherapeutic group: antiepileptics, other antiepileptics ATC code: N03AX14.
Danish: Farmakoterapeutisk klassifikation: antiepileptika, andre antiepileptika, ATC -kode: N03AX14.
English: This includes any possible side effects not listed in this leaflet.You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Danish: De eller Deres pårørende kan også indberette bivirkninger direkte til Lægemiddelstyrelsen via det nationale rapporteringssystem anført i Appendiks V. Ved at indrapportere bivirkninger kan De hjælpe med at fremskaffe mere information om sikkerheden af dette lægemiddel.
English: Do not use this medicine after the expiry date which is stated on carton box and blister after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på æsken og blisterkortet efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: The in vitro data and in vivo interaction data on oral contraceptives, digoxin and warfarin indicate that no significant enzyme induction is expected in vivo.
Danish: In vitro-data og in vivo-interaktionsdata med orale antikonceptionsmidler, digoxin og warfarin viste, at der ikke kan forventes signifikant enzyminduktion in vivo.
English: Six-month seizure freedom was achieved in 73.0% of levetiracetam-treated patients and 72.8% of carbamazepine-CR treated patients; the adjusted absolute difference between treatments was 0.2%
Danish: 6 måneders anfaldsfrihed blev opnået hos 73,0 % af de patienter, som blev behandlet med levetiracetam og hos 72,8 % af de patienter, som blev behandlet med carbamazepin CR; den tilpassede absolutte forskel mellem behandlingerne var 0,2 % (95 % CI: -7,8 8,2).
English: Accord Healthcare Limited Sage house, 319 Pinner road North Harrow HA1 4HF
Danish: Sage House, 319 Pinner road, North Harrow, HA1 4HF,
English: The patients were randomized to carbamazepine CR 400 - 1200 mg /day or levetiracetam 1000 - 3000 mg /day, the duration of the treatment was up to 121 weeks depending on the response.
Danish: Patienterne blev randomiseret til carbamazepin CR 400-1.200 mg/dag eller levetiracetam 1.000-3.000 mg/dag, varigheden af behandlingen var op til 121 uger afhængigt af respons.
English: 10 film-coated tablets 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 60 film-coated tablets 100 film-coated tablets 200 film-coated tablets 30 X 1 film-coated tablet 60 X 1 film-coated tablet 100 X 1 film-coated tablet
Danish: 10 filmovertrukne tabletter 20 filmovertrukne tabletter 30 filmovertrukne tabletter 50 filmovertrukne tabletter 60 filmovertrukne tabletter 100 filmovertrukne tabletter 200 filmovertrukne tabletter 30 x 1 filmovertrukne table 60 x 1 filmovertrukne tabletter 100 x 1 filmovertrukne tabletter
English: Somnolence, agitation, aggression, depressed level of consciousness, respiratory depression and coma were observed with Levetiracetam overdoses.
Danish: Døsighed, agitation, aggression, nedsat bevidsthedsniveau, repirationshæmning og koma blev set ved overdosering med Levetiracetam.
English: An oral solution is a formulation more appropriate to infants and children under the age of 6 years and to children and adolescent (from 6 to 17 years) weighing less than 50kg and when tablets don't allow accurate dosage.
Danish: En oral opløsning er den bedst egnede lægemiddelformulering til spædbørn og børn under 6 år og til børn og unge (fra 6 til 17 år), som vejer mindre end 50 kg, og hvor tabletter ikke muliggøre nøjagtig dosis.
English: Other medicines and Levetiracetam Accord Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Danish: Brug af anden medicin sammen med Levetiracetam Accord Fortæl altid lægen eller apoteketspersonalet, hvis De bruger anden medicin eller har gjort det for nylig.
English: Height (cm) x ks CLcr (ml/min/1.73 m2) = ----------------------------------Serum Creatinine (mg/dl)
Danish: Højde (cm) x ks CLcr (ml/min/1,73 m2) = ----------------------------------Serum-kreatinin (mg/dl)
English: Peak concentrations (Cmax) are typically 31 and 43 μg/ml following a single 1,000 mg dose and repeated 1,000 mg twice daily dose, respectively.
Danish: Maksimale koncentrationer er (Cmax) er normalt 31 og 43 ug/ml efter henholdsvis en enkelt dosis på 1.000 mg og gentagen dosering 1.000 mg 2 gange dagligt.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Danish: Yderligere oplysninger om Levetiracetam Accord findes på Det Europæiske Lægemiddelagenturs hjemmeside: http://www.ema.europa.eu.
English: Alopecia,eczema, pruritus,
Danish: Alopeci, eksem, pruritus
English: Levetiracetam Accord may impair your ability to drive or operate any tools or machinery, as it may make you feel sleepy.
Danish: Levetiracetam Accord kan påvirke Deres evne til at køre bil, motorcykel, cykle eller betjene værktøj og maskiner, da det kan give døsighed.
English: Accord Healthcare Limited Sage House
Danish: Accord Healthcare Limited,
English: Levetiracetam Accord 750 mg film-coated tablets contains sunset yellow (E110) which may cause allergic reactions.
Danish: Levetiracetam Accord 750 mg filmovertrukne tabletter indeholder Sunset Yellow (E110), der kan forårsage allergiske reaktioner.
English: • as an add-on to other antiepileptic medicines to treat: - partial onset seizures with or without generalisation in adults, adolescents, children and infants from one month of age; - myoclonic seizures (short, shock-like jerks of a muscle or group of muscles) in adults and adolescents from 12 years of age with juvenile myoclonic epilepsy - primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic generalised epilepsy (the type of epilepsy that is thought to have a genetic cause).
Danish: • som tillæg til andre lægemidler mod epilepsi til behandling af: partielle anfald med eller uden generalisering hos voksne, unge, børn og spædbørn, der er over 1 måned gamle myoklone anfald (korte, chok-lignende ryk i en muskel eller i en gruppe af muskler) hos voksne og unge over 12 år med juvenil myoklon epilepsi primært generaliserede tonisk-kloniske anfald (større anfald inklusiv bevidstløshed) hos voksne, unge over 12 år med idiopatisk generaliseret epilepsi (den type epilepsi, som menes at være genetisk forårsaget).
English: At 3600 mg /kg/day, in only one of the 2 EFD studies, there was a slight decrease in foetal weight associated with a marginal increase in skeletal variations/minor anomalies.
Danish: Kun i ét af de to embryo-føtale udviklingsstudier med 3.600 mg/kg/dag var der et lille fald i fostervægt forbundet med en marginal forøgelse af skeletale ændringer/mindre anomalier.
English: Swallow Levetiracetam Accord with a sufficient quantity of liquid (e.g. a glass of water).
Danish: Levetiracetam Accord tabletter synkes med rigelig væske (f.eks. et glas vand).
English: CLcr (ml/min) CLcr (ml/min/1.73 m2) = ---------------------------- x 1.73 BSA subject (m2)
Danish: CLcr (ml/min) CLcr (ml/min/1,73 m2) = ----------------------------- x 1,73
English: Dose in adults and adolescents (12 to 17 years) weighing 50 kg or more General dose: between 1,000 mg and 3,000 mg each day.
Danish: • Dosis til voksne og unge (12 til 17 år), som vejer 50 kg eller mere: Den sædvanlige dosis er mellem 1.000 mg og 3.000 mg dagligt.
English: The tablet core ingredients are: croscarmellose sodium, povidone K-30, colloidal anhydrous silica, magnesium stearate (E470b)
Danish: De øvrige indholdsstoffer i tabletkernen er: Croscarmellosenatrium, povidon K-30, vandfri kolloid silica, magnesiumstearat (E470b).
English: In adults, levetiracetam efficacy has been demonstrated in 3 double-blind, placebo-controlled studies at 1000 mg, 2000 mg, or 3000 mg /day, given in 2 divided doses, with a treatment duration of up to 18 weeks.
Danish: Levetiracetams virkning hos voksne er blevet demonstreret i 3 dobbeltblinde placebokontrollerede studier med hhv. 1.000 mg, 2.000 mg eller 3.000 mg/dag, fordelt på to doser, med en behandlingsvarighed på op til 18 uger.
English: You should continue Levetiracetam Accord treatment for as long as your doctor has told you.
Danish: Levetiracetam Accord så lang tid, som Deres læge har fortalt Dem.
English: Following repeated oral dose administration (20 to 60 mg /kg/day) to epileptic children (4 to 12 years), levetiracetam was rapidly absorbed.
Danish: Efter gentagen oral dosering (20 til 60 mg/kg/dag) til epileptiske børn (4-12 år) blev levetiracetam hurtigt absorberet.
English: In this study, the patients received levetiracetam as a fixed dose of 60 mg /kg/day (with twice a day dosing).
Danish: I dette studie fik patienterne levetiracetam i en fast dosis på 60 mg/kg/dag (fordelt på to doser dagligt).
English: Levetiracetam efficacy was established in a 24-week double-blind, placebo-controlled study which included adults, adolescents and a limited number of children suffering from idiopathic generalized epilepsy with primary generalized tonic-clonic (PGTC) seizures in different syndromes (juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, or epilepsy with Grand Mal seizures on awakening).
Danish: Levetiracetams virkning blev påvist i et 24 -ugers dobbeltblindt, placebokontrolleret studie, som omfattede voksne og unge samt et begrænset antal børn med idiopatisk generaliseret epilepsi med primært generaliserede tonisk-kloniske anfald (PGTC) i forskellige syndromer (juvenil myoklon epilepsi, juvenil absence epilepsi, børne absence epilepsi eller epilepsi med Grand Mal anfald ved opvågning).
English: Completed suicide,personality disorder, thinking abnormal, delirium
Danish: Selvmord, personlighedsforstyrrelse, abnorm tankegang, delirium
English: In this study, levetiracetam dose was 3000 mg /day for adults and adolescents or 60 mg /kg/day for children, given in 2 divided doses.
Danish: I dette studie var levetiracetam-dosis 3.000 mg/dag for voksne og unge og 60 mg/kg/dag for børn, fordelt på 2 doser.
English: Following single dose administration (20 mg /kg) of a 100 mg /ml oral solution to epileptic children (1 month to 4 years), levetiracetam was rapidly absorbed and peak plasma concentrations were observed approximately 1 hour after dosing.
Danish: Efter administration af en enkelt dosis (20 mg/kg) 100 mg/ml oral opløsning til epileptiske børn (1 måned til 4 år) blev levetiracetam hurtigt absorberet og peak-plasmakoncentrationer blev observeret ca. 1 time efter administration.
English: What you need to know before you take Levetiracetam Accord
Danish: Det skal De vide, før De begynder at tage Levetiracetam Accord
English: For children 6 years and above, Levetiracetam oral solution should be used for doses under 250 mg, for doses not multiple of 250 mg when dosing recommendation is not achievable by taking multiple tablets and for patients unable to swallow tablets.
Danish: For børn, der er 6 år og ældre, bør Levetiracetam oral opløsning anvendes ved doser under 250 mg, for doser, som ikke er delelig med 250 mg, når anbefalet dosis ikke kan opnås ved at tage flere tabletter og til patienter, som ikke er i stand til at synke tabletter.
English: A peri- and post-natal development study was performed in rats with levetiracetam doses of 70, 350 and 1800 mg/kg/day.
Danish: Der blev udført et peri- og postnatalt udviklingsstudie med levetiracetam-doser på 70, 350 og 1.800 mg/kg/dag i rotter.
English: • a more severe form of rash causing skin peeling in more than 30% of the body surface (toxic epidermal necrolysis)
Danish: • et mere alvorligt udslæt, der forårsager afskalning af huden på mere end 30 % af kropsoverfladen
English: Duration of treatment - Levetiracetam Accord is used as a chronic treatment.
Danish: • Levetiracetam Accord anvendes til kronisk behandling.
English: Levetiracetam Accord is used
Danish: Levetiracetam Accord anvendes
English: The other strengths of Levetiracetam tablets do not contain this ingredient.
Danish: De øvrige styrker af Levetiracetam Accord indeholder ikke dette farvestof.
English: Levetiracetam 1,000 mg daily did not influence the pharmacokinetics of oral contraceptives (ethinyl-estradiol and levonorgestrel); endocrine parameters (luteinizing hormone and progesterone) were not modified.
Danish: Orale kontraceptiva og andre farmakokinetiske interaktioner Levetiracetam 1.000 mg dagligt påvirker ikke farmakokinetikken af orale kontraceptiva (ethinylestradiol og levonorgestrel); endokrine parametre (luteiniserende hormon og progesteron) blev ikke ændret.
English: [140-age (years)] x weight (kg) CLcr (ml/min) = ----------------------------------------- (x 0.85 for women) 72 x serum creatinine (mg/dl)
Danish: CLcr (ml/min) = -----------------------------------------(x 0,85 for kvinder) 72 x serum-kreatinin (mg/dl)
English: • suicide, personality disorders (behavioural problems), thinking abnormal (slow thinking,
Danish: • selvmord, personlighedsforstyrrelser (adfærdsproblemer), unormal tankevirksomhed (langsom tankegang, koncentrationsbesvær);
English: Children and adolescents - Levetiracetam Accord is not indicated in children and adolescents below 16 years on its own
Danish: • Levetiracetam Accord er ikke indiceret til børn og unge under 16 år som eneste lægemiddel
English: Excipient with known effect: Each film-coated tablet contains 0.013 mg of sunset yellow FCF (E110)
Danish: Hjælpestof(fer), som behandleren skal være opmærksom på Hver filmovertrukne tablet indeholder 0,013 mg Sunset Yellow FCF (E110).
English: Following single oral dose administration (20 mg /kg) to epileptic children (6 to 12 years), the half-life of levetiracetam was 6.0 hours.
Danish: Efter indgivelse af en enkelt oral dosis (20 mg/kg) til børn (6-12 år) med epilepsi, var halveringstiden for levetiracetam 6,0 timer.
English: Efficacy of levetiracetam as monotherapy was established in a double-blind, parallel group, non-inferiority comparison to carbamazepine controlled release (CR) in 576 patients 16 years of age or older with newly or recently diagnosed epilepsy.
Danish: Levetiracetams virkning som monoterapi blev påvist i et dobbeltblindt, ækvivalensstudie med parallelle grupper med carbamazepin -depottabletter (CR) hos 576 patienter over 16 år med ny eller nyligt diagnosticeret epilepsi.
English: Levetiracetam Accord film-coated tablets 250 mg, 500 mg, 750 mg and 1000 mg are packed in PVC-Alu blister pack.
Danish: Levetiracetam Accord filmovertrukne tabletter 250 mg, 500 mg, 750 mg og 1000 mg er pakket i PVCaluminium-blisterpakninger.
English: In addition, the available dose strengths of the tablets are not appropriate for initial treatment in children weighing less than 25 kg, for patients unable to swallow tablets or for the administration of doses below 250 mg.
Danish: Desuden er de tilgængelige tabletstyrker ikke egnet til initialbehandling af børn, som vejer mindre end 25 kg, til patienter, som ikke er i stand til at synke tabletter, eller til administration af doser under 250 mg. I alle ovennævnte tilfælde skal Levetiracetam oral opløsning anvendes.
English: Do not take Levetiracetam Accord - If you are allergic to levetiracetam, pyrrolidone derivatives or any of the other ingredients of this medicine (listed in section 6).
Danish: • Hvis De er allergisk over for levetiracetam, pyrrolidonderivater eller et af de øvrige indholdsstoffer i Levetiracetam Accord (angivet i pkt.
English: Levetiracetam oral solution is the preferred formulation for use in infants and children under the age of 6 years.
Danish: Levetiracetam oral opløsning bør foretrækkes til spædbørn og børn under 6 år.
English: Each film-coated tablet contains 250 mg, 500 mg, 750 mg or 1000 mg of levetiracetam.
Danish: Hver filmovertrukken tablet indeholder 250 mg, 500 mg, 750 mg eller 1000 mg levetiracetam.
English: Suicide attempt, suicidal ideation, psychotic disorder, abnormal behaviour, hallucination,anger, confusional state, panic attack, affect lability/mood swings, agitation
Danish: Selvmordsforsøg, selvmordstanker, psykose, unormal adfærd, hallucinationer, vrede, konfusion, panikanfald, affektlabilitet/ humørsvingninger, agitation
English: Four embryo-foetal development studies were performed in rabbits covering doses of 200, 600, 800, 1200 and 1800 mg /kg/day.
Danish: Der blev udført fire embryo-føtale udviklingsstudier med doser på 200, 600, 800, 1.200 og 1.800 mg/kg/dag i kaniner.