FrancophonIA/ELRC3.0 huggingface dataset:
English: • increased blood level of creatinine (a substance normally removed by the kidneys into the urine), increased blood level of lactate dehydrogenase (a substance that indicates tissue or cellular damage)
Danish: • forhøjet niveau af kreatinin (et stof, der normalt fjernes af nyrerne til urinen) i blodet, forhøjet niveau af lactatdehydrogenase i blodet (et stof, der indikerer vævs- eller celleskade)
English: A report from an investigator-initiated trial performed in children with primary immunodeficiencies lists four cases of seizures occurring after other treosulfan-based conditioning regimens (see section 4.4).
Danish: En rapport fra et investigator-initieret studie hos børn med primære immundefekter anfører 4 tilfælde af krampeanfald, der opstod efter andre treosulfan-baserede konditioneringsprogrammer (se pkt.
English: The immunosuppressive effects of treosulfan are attributed to its toxicity against primitive and committed progenitor cells, T and NK cells, reduction of cellularity of primary and secondary lymphatic organs and a preclusive effect on the ‘cytokine storm' that precedes the development of Graft-versus-Host-Disease (GvHD) and is involved in the pathogenesis of veno-occlusive disease.
Danish: Den immunundertrykkende virkning af treosulfan tilskrives toksiciteten mod primitive og specialiserede progenitorceller, T- og NK-celler, reduktion af cellularitet af primære og sekundære lymfatiske organer og en forebyggende virkning på 'cytokin-stormen', der går forud for udviklingen af Graft-versus-Host-Disease (GvHD) og er involveret i patogenesen for venookklusiv sygdom.
English: What you need to know before you are given Trecondi
Danish: Det skal du vide, før du begynder at få Trecondi
English: Trecondi is available in packs of 1 or 5 vials.
Danish: Trecondi fås i pakninger med 1 eller 5 hætteglas.
English: Therefore, men treated with treosulfan are advised not to father a child during and up to 6 months after treatment and to seek advice on cryo-conservation of sperm prior to treatment because of the possibility of irreversible infertility due to therapy with treosulfan.
Danish: Derfor frarådes mænd, der er i behandling med treosulfan, at gøre en kvinde gravid under behandlingen og op til 6 måneder efter behandlingen, og de tilrådes at søge rådgivning om kryo-konservering af sæd, før behandlingen påbegyndes, på grund af muligheden for irreversibel infertilitet som følge af behandlingen med treosulfan.
English: Use of mucositis prophylaxis (e.g. topical antimicrobials, barrier protectants, ice and adequate oral hygiene) is recommended.
Danish: Brugen af profylakse mod mucositis (f.eks. topikale antimikrobielle midler, barrierebeskyttende midler, is og tilstrækkelig oral hygiejne) anbefales.
English: The median (25%/75% percentiles) duration of neutropenia was 21 (16, 26) days in paediatric patients with malignant diseases and 24 (17, 26) days in patients with non-malignant disorders.
Danish: Den mediane (25 %/75 % percentiler) varighed af neutropeni var 21 (16; 26) dage hos pædiatriske patienter med malign sygdom og 24 (17; 26) dage hos patienter med ikke-malign sygdom.
English: Gastrointestinal disorders were observed in 357 patients (63.3%).
Danish: Der blev observeret mave-tarm-forstyrrelser hos 357 patienter (63,3 %).
English: Treosulfan is a prodrug that is spontaneously converted under physiological conditions (pH 7.4; 37 °C) into a monoepoxide intermediate and L-diepoxybutane with a half-life of 2.2 hours.
Danish: Treosulfan er et prodrug, der omdannes spontant under fysiologiske betingelser (pH 7,4, 37 °C) til et monoepoxidmellemprodukt og L-diepoxybutan med en halveringstid på 2,2 timer.
English: Maximum plasma levels (mean ± SD) in adult patients after a 2-hour intravenous infusion of 10, 12, or 14 g/m² treosulfan were 306 ± 94 µg/mL, 461 ± 102 µg/mL, and 494 ± 126 µg/mL, respectively.
Danish: Maksimale plasmaniveauer (gennemsnit ± SD) hos voksne patienter efter en 2-timers intravenøs infusion med 10, 12 eller 14 g/m² treosulfan var hhv. 306 ± 94 µg/ml, 461 ± 102 µg/ml og 494 ± 126 µg/ml.
English: Within each frequency group, undesirable effects are presented in order of decreasing seriousness.
Danish: Inden for hver hyppighedsgruppe er bivirkningerne opstillet efter, hvor alvorlige de er.
English: Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adult patients with malignant and non-malignant diseases, and in paediatric patients older than one month with malignant diseases.
Danish: Treosulfan i kombination med fludarabin er indiceret som en del af konditionerende behandling før allogen hæmatopoeitisk stamcelletransplantation (alloHSCT) til voksne patienter med maligne og ikke-maligne sygdomme og til pædiatriske patienter, der er over en måned gamle, med maligne sygdomme.
English: The overall survival at 12 months is 91.4% (90% CI 83.9-95.5%).
Danish: Den samlede overlevelse efter 12 måneder er 91,4 % (90 % CI 83,9-95,5 %).
English: All Adverse Reactions / Frequency Grade 3-4 Adverse Reactions / Frequency
Danish: Alle bivirkninger / hyppighed Grad 3-4 bivirkninger / hyppighed
English: Not known Embolism, haemorrhage
Danish: Ikke kendt Embolisme, hæmoragi
English: Do not use Trecondi:  if you are allergic to treosulfan,  if you suffer from an active uncontrolled infection,  if you suffer from severe heart, lung, liver or kidney diseases,  if you suffer from hereditary DNA repair disorder, a condition that reduces the ability to repair
Danish: Brug ikke Trecondi:  hvis du er allergisk over for treosulfan,  hvis du lider af en aktiv, ukontrolleret infektion,  hvis du lider af svære hjerte-, lunge-, lever- eller nyresygdomme,  hvis du lider af hereditær (arvelig) dna-reparationssygdom, en tilstand, hvor evnen til at reparere dna (som indeholder din genetiske information) er reduceret,  hvis du er gravid eller tror du kan være gravid.
English: Profound myelosuppression/pancytopenia is the desired therapeutic effect of conditioning therapy and occurs in all patients.
Danish: Markant myelosuppression/pancytopeni er den ønskede terapeutiske virkning af konditionerende behandling og forekommer hos alle patienter.
English: Complete disease responses were observed in 28 patients (90%), as measured by clinical symptoms and laboratory assays (Burroughs LM et al., Biology of Blood and Marrow Transplantation 2014; 20(12):1996-2003).
Danish: Der blev observeret et fuldstændigt sygdomsrespons hos 28 patienter (90 %), målt ved kliniske symptomer og laboratorieanalyser (Burroughs LM et al., Biology of Blood and Marrow Transplantation 2014;
English: It is given by drip (infusion) into a vein over 2 hours for 3 days before blood stem cell infusion.
Danish: Det gives via et drop (infusion) i en vene i løbet af 2 timer i 3 dage før en blodstamcelleinfusion.
English: Ovarian suppression and amenorrhoea with menopausal symptoms commonly occur in pre-menopausal patients (see section 4.6).
Danish: Ovariesuppression og amenoré med menopausale symptomer er almindeligt forekommende hos præmenopausale patienter (se pkt.
English: • less acid than normal in the blood (alkalosis), abnormal blood level of electrolytes, decreased blood level of magnesium
Danish: • mindre syre i blodet end normalt (alkalose), unormalt niveau af elektrolytter i blodet, nedsat niveau af magnesium i blodet
English: Prophylactic use of mouthwashes (e.g. with barrier protectants, antimicrobials) or application of ice within the oral cavity (lessens blood flow to the oral mucosa and reduces the amount of treosulfan reaching the cell) is recommended.
Danish: Profylaktisk brug af mundskylning (f.eks. med barrierebeskyttelse, antimikrobielle midler) eller indsætning af is i mundhulen (som reducerer blodtilførslen til slimhinden i munden og nedsætter mængden af treosulfan, der når cellerne) anbefales.
English: The incidence of complete donor-type chimerism was 94.2% (90% CI 87.2-98.0%) at day +28 visit, 91.3% (90% CI 83.6-96.1%) at day +100 visit and 91.2% (90% CI 82.4-96.5%) at month 12 visit.
Danish: Forekomsten af fuldstændig donortypekimærisme var 94,2 % (90 % CI 87,2-98,0 %) ved besøget på dag +28, 91,3 % (90 % CI 83,6-96,1 %) ved besøget på dag +100 og 91,2 % (90 % CI 82,4-96,5 %) ved besøget efter måned 12.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Carton
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Karton
English: The frequencies of adverse reactions reported in the table below are derived from 5 clinical trials (including a total of 564 patients) where treosulfan combined with fludarabine was investigated as conditioning treatment prior to alloHSCT in adult patients.
Danish: Hyppighederne af bivirkninger rapporteret i den nedenstående tabel er afledt fra 5 kliniske studier (der inkluderede i alt 564 patienter), hvor treosulfan kombineret med fludarabin blev undersøgt som konditionerende behandling før alloHSCT hos voksne patienter.
English: The lowest frequencies of these adverse reactions were seen with the dose regimen of 10 g/m² per day, day -4 to -2 (20.4%, 30.3%, 13.1%, 5.0%, and 5.5% respectively).
Danish: De laveste hyppigheder af disse bivirkninger blev observeret med dosisprogrammet med 10 g/m² dagligt, dag -4 til -2 (hhv. 20,4 %, 30,3 %, 13,1 %, 5,0 % og 5,5 %).
English: To avoid solubility problems, warm the solvent, sodium chloride 4.5 mg/mL (0.45%) solution, to 25 °C - 30 °C (not higher), for example by using a water bath.
Danish: For at undgå problemer med opløselighed skal solvenset, natriumchloridopløsning 4,5 mg/ml (0,45 %), opvarmes til 25 °C - 30 °C (ikke varmere), for eksempel ved hjælp af et vandbad.
English: Treosulfan was administered in a dose range of 10-14 g/m² BSA on 3 consecutive days.
Danish: Treosulfan blev administreret i et dosisinterval på 10-14 g/m² BSA i 3 på hinanden følgende dage.
English: Treosulfan is given in combination with fludarabine.
Danish: Treosulfan gives i kombination med fludarabin.
English: c For testing superiority of treosulfan compared to busulfan.
Danish: For test af superioritet af treosulfan sammenlignet med busulfan.
English: VOD occurred only with the dose regimen of 14 g/m²/day treosulfan.
Danish: VOD opstod kun med dosisprogrammet med 14 g/m²/dag treosulfan.
English: • abnormal brain function (encephalopathy), bleeding in the brain, restless, repetitive, or involuntary movements and rapid speech (extrapyramidal disorder), fainting, sensation of tingling, pricking or numbness (paraesthesia)
Danish: • unormal hjernefunktion (encefalopati), blødning i hjernen, rastløse, gentagne eller ufrivillige bevægelser og hurtig tale (ekstrapyramidal sygdom), besvimelse, følelse af prikken, stikken eller følelsesløshed (paræstesi)
English: The adverse reactions reported in the table below are derived from two clinical trials (including a total of 88 patients; median age 8 years [range 0-17 years]) where treosulfan combined with fludarabine (and mostly with additional thiotepa) was administered as conditioning treatment prior to alloHSCT in paediatric patients with malignant or non-malignant diseases.
Danish: De rapporterede bivirkninger i tabellen nedenfor er udledt fra 2 kliniske studier (der inkluderede i alt 88 patienter; medianalder 8 år [interval 0-17 år]), hvor treosulfan kombineret med fludarabin (og for det meste yderligere med thiotepa) blev administreret som konditionerende behandling før alloHSCT hos pædiatriske patienter med malign eller ikke-malign sygdom.
English: The efficacy and safety of treosulfan-based conditioning was evaluated in 70 patients with acute lymphoblastic leukaemia (ALL), AML, MDS, or juvenile myelomonocytic leukaemia (JMML) who received a conditioning regimen with treosulfan and fludarabine with (n = 65) or without (n = 5) thiotepa (see section 4.2).
Danish: Virkningen og sikkerheden af treosulfan-baseret konditionering blev evalueret hos 70 patienter med akut lymfoblastisk leukæmi (ALL), AML, MDS eller juvenil myelomonocytisk leukæmi (JMML), som fik et konditioneringsprogram med treosulfan og fludarabin med (n = 65) eller uden (n = 5) thiotepa (se pkt.
English: How Trecondi is given
Danish: Sådan gives Trecondi
English: This was demonstrated against transplanted mouse and rat lymphomas/leukaemias, sarcomas and hepatomas, human tumour xenografts, human tumour biopsies and cell lines.
Danish: Dette er vist for transplanterede muse- og rottelymfomer/leukæmier, sarkomer og hepatomer, humane tumorxenografter, humane tumorbiopsier og cellelinjer.
English: Under physiological conditions (pH 7.4, temperature 37 °C), the pharmacologically inactive treosulfan is converted spontaneously (non-enzymatically) into the active monoepoxide intermediate (S,S-EBDM = (2S,3S)-1,2-epoxybutane-3,4-diol-4-methanesulfonate) and finally to L-diepoxibutane (S,S-DEB = (2S,3S)-1,2:3,4-diepoxybutane).
Danish: Under fysiologiske betingelser (pH 7,4, temperatur 37 °C) omdannes det farmakologisk inaktive treosulfan spontant (ikke-enzymatisk) til det aktive monoepoxidmellemprodukt (S,S-EBDM = (2S,3S)-1,2-epoxybutan-3,4-diol-4-methansulfonat) og til sidst til L-diepoxybutan (S,S-DEB = (2S,3S)-1,2:3,4-diepoxybutan).
English: Adequate care and precautions should be taken in the disposal of items (syringes, needles, etc.) used to reconstitute cytotoxic medicinal products.
Danish: Der skal udvises forsigtighed og tages passende forholdsregler, når dele (sprøjter, kanyler mm.), der anvendes til at rekonstituere cytotoksiske lægemidler, bortskaffes.
English: The recommended dose is 10-14 g/m² body surface area.
Danish: Den anbefalede dosis er 10-14 g/m² legemsoverfladeareal.
English: The most frequent adverse reactions were cardiac arrhythmias, e.g. atrial fibrillation (1.2%), sinus tachycardia (0.9%), supraventricular tachycardia (0.4%), and ventricular extrasystole (0.4%).
Danish: De hyppigste bivirkninger var hjertearytmier, f.eks. atrieflimmer (1,2 %), sinustakykardi (0,9 %), supraventrikulær takykardi (0,4 %) og ventrikulær ekstrasystole (0,4 %).
English: Analyses of EFS at 2 years for various pre-defined subgroups (donor type, risk group, disease, age group, HCT-CI score, remission status at study entry, and various combinations of these parameters) were always in favour of the treosulfan regimen (hazard ratio [HR] of FT10 vs. FB2 < 1), with only one exception (risk group I of MDS patients; HR 1.14 [95% CI 0.48, 2.63]).
Danish: Analyser af EFS efter 2 år for forskellige prædefinerede undergrupper (donortype, risikogruppe, sygdom, aldersgruppe, HCT-CI-score, remissionsstatus ved indgang i studiet og forskellige kombinationer af disse parametre) var altid favorable for treosulfan-programmet (hazard ratio [HR] for FT10 vs. FB2 < 1) med kun én undtagelse (risikogruppe I med MDS-patienter, HR 1,14 [95 % CI 0,48;
English: Five cases of a second malignancy (myelodysplastic syndrome, acute lymphoblastic leukaemia, Ewing's sarcoma) were reported by other investigators after treosulfan-based conditioning.
Danish: cyster og polypper) 5 tilfælde af sekundær malignitet (myelodysplastisk syndrom, akut lymfoblastisk leukæmi, Ewings sarkom) er rapporteret af andre investigatorer efter treosulfan-baseret konditionering.
English: Very common Stomatitis/mucositis, nausea
Danish: Meget almindelig Stomatitis/mukositis, kvalme
English: Uncommon Hyperglycaemia
Danish: Ikke almindelig Hyperglykæmi
English: Very common Pyrexiac
Danish: Meget almindelig Pyreksic
English: If you were given more Trecondi than you should Because this medicine is given by a doctor, you will be given the correct dose.
Danish: Da dette lægemiddel gives af en læge, vil du få den korrekte dosis.
English: Treosulfan is a prodrug of a bifunctional alkylating agent with cytotoxic activity to haematopoietic precursor cells.
Danish: Treosulfan er et prodrug af et bifunktionelt alkyleringsmiddel med cytotoksisk aktivitet mod hæmatopoietiske precursorceller.
English: Isolated cases of cardiac arrest, cardiac failure, and myocardial infarction occurred.
Danish: Der opstod isolerede tilfælde af hjertestop, hjertesvigt og myokardieinfarkt.
English: • bloodstream infection (sepsis)
Danish: • infektion i blodkredsløbet (sepsis)
English: The activity of treosulfan is due to the spontaneous conversion into a mono-epoxide intermediate and L-diepoxybutan (see section 5.2).
Danish: Treosulfans aktivitet skyldes den spontane omdannelse til et monoepoxidmellemprodukt og L-diepoxybutan (se pkt.
English: The main indications for an alloHSCT with treosulfan conditioning in adult NMD patients are haemoglobinopathies (e.g. sickle cell disease, thalassaemia major [TM]), primary immune deficiency, hemophagocytic disorder, immune dysregulatory disorder and bone marrow failure).
Danish: De primære indikationer for en alloHSCT med treosulfan-konditionering hos voksne patienter med NMD er hæmoglobinopatier (f.eks. seglcellesygdom, thalassaemia major [TM]), primær immundefekt, hæmofagocytisk sygdom, immundysreguleringssygdom og knoglemarvssvigt.
English: • increased acidity in the blood, abnormal control of blood sugar level, abnormal blood level of electrolytes (salts in the blood)
Danish: • øget surhedsgrad i blodet, unormal kontrol af sukkerniveauet i blodet, unormalt niveau af elektrolytter i blodet (salte i blodet)
English: Nappy rash with ulceration of the area around the anus (perianal) may occur in infants, toddlers and children wearing nappies because treosulfan passed out in the urine can damage the skin.
Danish: Bleeksem med sårdannelse i området rundt om anus (perianalt) kan opstå hos spædbørn, småbørn og blebørn, da treosulfan, som udskilles i urinen, kan skade huden.
English: Blood creatinine increased, blood lactate dehydrogenase (LDH) increased
Danish: Forhøjet kreatinin i blodet, forhøjet laktatdehydrogenase (LDH) i blodet
English: When handling treosulfan, inhalation, skin contact or contact with mucous membranes should be avoided (the use of adequate protective disposable gloves, goggles, gown and mask is recommended).
Danish: Når treosulfan håndteres, skal der undgås inhalation, hudkontakt eller kontakt med slimhinder (det anbefales at bruge engangshandsker, øjenværn, dragt og maske, der yder tilstrækkelig beskyttelse).
English: Each vial contains 5 g treosulfan.
Danish: Hvert hætteglas indeholder 5 g treosulfan.
English: Common Hypersensitivity
Danish: Almindelig Overfølsomhed
English: Published literature data report on gonadotoxicity of treosulfan in pre-pubertal and pubertal male and female mice.
Danish: Publicerede data fra litteraturen om treosulfan rapporterer om gonadotoksicitet hos præpubertale og pubertale han- og hunmus.
English: All patients engrafted, with a median time to neutrophil engraftment of 21 (range, 12-46) days.
Danish: Transplantationen virkede hos alle patienterne, med en mediantid til, at neutrofilerne havde slået sig ned i knoglemarven, på 21 (interval 12-46) dage.
English: Not known Veno-occlusive liver disease
Danish: Ikke kendt Venookklusiv leversygdom
English: After reconstitution with sodium chloride 4.5 mg/mL (0.45%) solution, chemical and physical stability has been demonstrated for 2 days at 25 °C.
Danish: Efter rekonstitution med natriumchloridopløsning 4,5 mg/ml (0,45 %) er der blevet vist kemisk og fysisk stabilitet i 2 dage ved 25 °C.
English: For preparation of sodium chloride 4.5 mg/mL (0.45%) solution equivalent volumes of sodium chloride 9 mg/mL (0.9%) solution and water for injections can be mixed.
Danish: Natriumchloridopløsningen på 4,5 mg/ml (0,45 %) kan forberedes ved at blande ækvivalente voluminer af natriumchloridopløsning 9 mg/ml (0,9 %) og vand til injektionsvæsker.
English: Transaminases (ALT/AST) increased, bilirubin increased
Danish: Forhøjede transaminaser (ALAT/ASAT), forhøjet bilirubin
English: * See detailed sections below a Clinically or microbiologically documented infection with grade 3 or 4 neutropenia (absolute neutrophil count [ANC] < 1.0 x 109/L) and sepsis b Acidosis might be a consequence of the release of methanesulfonic acid through treosulfan activation/cleavage in the plasma c Case reports (> 2) after treosulfan-based conditioning obtained from other sources d Bronze pigmentation e Fever in the absence of neutropenia where neutropenia is defined as ANC < 1.0 x 109/L
Danish: * Se detaljerede afsnit nedenfor a Klinisk eller mikrobiologisk dokumenteret infektion med grad 3 eller 4 neutropeni (absolut neutrofiltal [ANC] < 1,0 x 109/l) og sepsis b Acidose kan være en følgevirkning af frigivelsen af methansulfonsyre via treosulfanaktivering/spaltning i plasma c Sagsrapporter (> 2) efter treosulfan-baseret konditionering indhentet fra andre kilder d Bronzefarvet pigmentering e Feber uden neutropeni, hvor neutropeni er defineret som ANC < 1,0 x 109/l
English: Treosulfan has mutagenic and carcinogenic potential.
Danish: Treosulfan har mutagene og karcinogene egenskaber.
English: Treosulfan can impair fertility.
Danish: Treosulfan kan forringe fertiliteten.
English: Blood alkaline phosphatase increased, C-reactive protein increased
Danish: Forhøjet basisk fosfatase i blodet, forhøjet C-reaktivt protein
English: The median (25%/75% percentiles) duration of neutropenia was 14 (12, 20) days with the 10 g/m² treosulfan dose and 17.5 (14, 21) days with the 14 g/m² treosulfan dose.
Danish: Den mediane (25 %/75 % percentiler) varighed af neutropeni var 14 (12; 20) dage med en treosulfandosis på 10 g/m² og 17,5 (14; 21) dage med en treosulfan-dosis på 14 g/m².
English: No specific antidote of treosulfan overdose is known.
Danish: Der er ingen kendt specifik antidot til treosulfan.
English: In the pivotal phase III trial, adult patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and increased risk for standard conditioning therapies because of higher age (≥ 50 years) or comorbidities (haematopoietic cell transplantation comorbidity index [HCT-CI] score > 2) were randomised to receive a conditioning regimen with 3 × 10 g/m² treosulfan combined with fludarabine (FT10; n = 220) or a regimen of intravenous busulfan (total dose 6.4 mg/kg) combined with fludarabine (FB2; n = 240), followed by alloHSCT.
Danish: I det pivotale fase III-studie blev voksne patienter med akut myeloid leukæmi (AML) eller myelodysplastisk syndrom (MDS) og en øget risiko ved standard konditionerende behandling som følge af højere alder (≥ 50 år) eller komorbiditeter (hæmatopoietisk celletransplantation komorbiditetsindeks-score [HCT-CI-score] > 2) randomiseret til at få konditionerende behandling med 3 × 10 g/m² treosulfan kombineret med fludarabin (FT10; n = 220) eller et program med intravenøs busulfan (total dosis 6,4 mg/kg) kombineret med fludarabin (FB2; n = 240), efterfulgt af alloHSCT.
English: The most commonly observed adverse reactions (adults/paediatric patients) after treosulfan-based conditioning followed by alloHSCT include infections (13.1% /11.4%), gastrointestinal disorders (nausea [39.5%/30.7%], stomatitis [36.0%/69.3%], vomiting [22.5%/43.2%], diarrhoea [15.6%/33.0%], abdominal pain [10.4%/17%]), fatigue (15.1%/2.3%), febrile neutropenia (11.3%/1.1%), oedema (7.8%/0%), rash (7.2%/12.5%), and increases of alanine transaminase (ALT [5.1%/9.1%]), aspartate transaminase (AST [4.4%/8.0%]), gamma-glutamyl transferase (γGT [3.7%/2.3%]), and bilirubin (18.8%/5.7%).
Danish: De mest almindeligt observerede bivirkninger (voksne/pædiatriske patienter) efter treosulfan-baseret konditionering efterfulgt af alloHSCT omfatter infektioner (13,1 %/11,4 %), mave-tarm-sygdomme (kvalme [39,5 %/30,7 %], stomatitis [36,0 %/69,3 %], opkastning [22,5 %/43,2 %], diarré [15,6 %/33,0 %], abdominalsmerter [10,4 %/17 %]), træthed (15,1 %/2,3 %), febril neutropeni (11,3 %/1,1 %), ødem (7,8 %/0 %), udslæt (7,2 %/12,5 %) og forhøjede niveauer af alanintransaminase (ALAT [5,1 %/9,1 %]), aspartattransaminase (ASAT [4,4 %/8,0 %]), gamma-glutamyltransferase (γGT [3,7 %/2,3 %]) og bilirubin (18,8 %/5,7 %).
English: 1 vial 5 vials
Danish: 1 hætteglas 5 hætteglas
English: If you get any side effects, talk to your doctor, pharmacist or nurse.
Danish: Indberetning af bivirkninger Hvis du oplever bivirkninger, bør du tale med din læge, sygelejerske eller apoteket.