FrancophonIA/ELRC3.0 huggingface dataset:
English: White High Density Polyethylene (HDPE) bottles containing 240 ml of oral solution.
Slovenian: Bele plastenke iz polietilena visoke gostote (HDPE), ki vsebujejo 240 ml peroralne raztopine.
English: Those of at least 13 years of age and weighing at least 50 kg received 1200 mg Agenerase twice daily.
Slovenian: Otroci, stari najmanj 13 let in s telesno maso najmanj 50 kg, so prejemali zdravilo Agenerase v odmerku 1.200 mg dvakrat na dan.
English: It is a clear, pale yellow to yellow solution with grape, bubblegum and peppermint flavouring.
Slovenian: Je bistra, bledo rumena do rumena raztopina z aromo grozdja, žvečilnega gumija in poprove mete.
English: Capsule contents: d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), macrogol 400 (PEG 400), propylene glycol.
Slovenian: Vsebina kapsule: D-α-tokoferilpolietilenglikol 1000 sukcinat (TPGS), makrogol 400 (PEG 400), propilenglikol.
English: Patients of 4 years and older unable to swallow Agenerase capsules: the recommended dose of Agenerase oral solution is 17 mg (1.1 ml)/kg three times a day, in combination with other antiretroviral agents, without exceeding a total daily dose of 2800 mg (see section 5.1).
Slovenian: Bolniki stari 4 leta in starejši, ki ne zmorejo pogoltniti kapsul Agenerase: Priporočen odmerek peroralne raztopine Agenerase je 17 mg (1,1 ml)/kg trikrat dnevno v kombinaciji z drugimi protiretrovirusnimi zdravili, skupni dnevni odmerek pa ne sme presegati 2800 mg (glejte poglavje 5.1).
English: Three of 14 isolates had protease resistance mutations.
Slovenian: Rezistenčna mutacija proteaze je bila prisotna pri 3 od 14 izolatov.
English: When methadone is co-administered with amprenavir, patients should be monitored for opiate abstinence syndrome, in particular if low-dose ritonavir is also given.
Slovenian: Če se metadon uporablja sočasno z amprenavirjem, je potrebno bolnike nadzirati glede opiatnega abstinenčnega sindroma, še posebno ob sočasni uporabi nizkih odmerkov ritonavirja.
English: Rare side effects (these can affect 1 in 1,000 patients treated)
Slovenian: Redki neželeni učinki (ki se lahko pojavijo pri 1 od 1.000 zdravljenih bolnikov)
English: The AUC and the Cmax of amprenavir were unaltered.
Slovenian: AUC in Cmax amprenavirja sta ostali nespremenjeni.
English: The combination of rifampicin and Agenerase with concomitant low-dose ritonavir is contraindicated (see section 4.3).
Slovenian: Kombinacija rifampicina in zdravila Agenerase skupaj z nizkim odmerkom ritonavirja je kontraindicirana (glejte poglavje 4.3).
English: Because Agenerase capsules contain vitamin E, you should not take additional vitamin E supplements.
Slovenian: Ker kapsule Agenerase vsebujejo vitamin E, le-tega ne jemljite še dodatno.
English: These active substances include flecainide and propafenone (see section 4.3).
Slovenian: Takšni učinkovini sta tudi flekainid in propafenon (glejte poglavje 4.3).
English: The oral solution is clear, pale yellow to yellow with grape, bubblegum and peppermint flavouring.
Slovenian: Peroralna raztopina je bistra, bledo rumena do rumena z aromo grozdja, žvečilnega gumija in poprove mete.
English: Because of the potential risk of toxicity from the large amount of the excipient propylene glycol, Agenerase oral solution is contraindicated in infants and children below the age of 4 years, pregnant women, patients with hepatic impairment or failure and patients with renal failure.
Slovenian: Zaradi visoke vsebnosti propilenglikola kot pomožne snovi in s tem povezane možne toksičnosti, je peroralna raztopina Agenerase kontraindicirana pri dojenčkih, otrocih mlajših od 4 let, nosečnicah, bolnikih z oslabljenim delovanjem ali odpovedjo jeter in pri bolnikih z odpovedjo ledvic.
English: The AUC increased nearly three-fold in patients with moderate impairment and four fold in patients with severe hepatic impairment.
Slovenian: Pri bolnikih z zmerno obliko oslabljenega delovanja se je AUC povečala skoraj za trikrat, pri tistih s hudo obliko pa za štirikrat.
English: Important information about ingredients of Agenerase oral solution The oral solution contains propylene glycol, which can cause adverse effects in high doses.
Slovenian: Pomembne informacije o nekaterih sestavinah kapsul Agenerase Peroralna raztopina vsebuje propilenglikol, ki lahko pri velikih odmerkih povzroči neželene učinke.
English: EXPIRY DATE EXP {MM/YYYY}
Slovenian: DATUM IZTEKA ROKA UPORABNOSTI ZDRAVILA EXP: {MM/LLLL}
English: In clinical studies, the safety and efficacy of amprenavir have not yet been established in children below four years of age.
Slovenian: Varnost in učinkovitost amprenavirja pri otrocih, mlajših od 4 let, še nista bili dokazani s kliničnimi študijami.
English: Other possible effects
Slovenian: Ostali možni neželeni učinki
English: This must be considered when prescribing to patients with reduced kidney function or patients on a controlled potassium diet.
Slovenian: Pozornost je potrebna pri bolnikih, ki imajo oslabljeno delovanje ledvic in bolnikih, ki so na diati z nižanjem kalija.
English: • Increases in the blood of a substance called bilirubin
Slovenian: • Povečane vrednosti bilirubina v krvi.
English: Medicinal products - interactions
Slovenian: Interakcije z zdravili
English: The Cmax, AUC and Cmin of amprenavir were unchanged.
Slovenian: Vrednosti Cmax, AUC in Cmin amprenavirja so ostale nespremenjene.
English: The metabolites and unchanged amprenavir account for approximately 14 % of the administered amprenavir dose in the urine, and approximately 75 % in the faeces.
Slovenian: Približno 14 % amprenavirja se izloči v obliki presnovkov ali nespremenjeni obliki z urinom, približno 75 % pa z blatom.
English: Less than 3 % of the therapeutic dose of amprenavir is excreted unchanged in the urine.
Slovenian: Z urinom se v nespremenjeni obliki izloči manj kot 3 % terapevtskega odmerka amprenavirja.
English: - The use of Agenerase together with ritonavir has not been studied in patients with liver disease.
Slovenian: - Uporaba zdravila Agenerase skupaj z ritonavirjem pri bolnikih z jetrno boleznijo ni bila raziskana.
English: As compared to a non-matched historical control group, co-administration of methadone and amprenavir resulted in a 30%, 27% and 25% decrease in serum amprenavir AUC, Cmax and Cmin respectively.
Slovenian: Primerjava z neenakovredno kontrolno historično skupino pokaže, da je sočasna uporaba metadona in amprenavirja imela za posledico zmanjšanje AUC, Cmax in Cmin amprenavirja v serumu: AUC za 30 %, Cmax za 27 % in Cmin za 25 %.
English: The number of key PI-resistance mutations increases markedly the longer a failing PI-containing regimen is continued.
Slovenian: Število ključnih mutacij, povezanih z rezistenco na zaviralce proteaz, znatno narašča z daljšanjem trajanja neuspešnega zdravljenja s kombinacijami, ki vključujejo zaviralce proteaz.
English: Coadministration of fosamprenavir 700 mg with ritonavir 100 mg twice daily and ketoconazole 200 mg once daily increased plasma ketoconazole Cmax by 25 % and increased AUC(0-τ) to values 2.69-fold those observed on administration of ketoconazole 200 mg once daily without concurrent fosamprenavir with ritonavir.
Slovenian: Pri sočasni uporabi fosamprenavirja v odmerku 700 mg skupaj z ritonavirjem v odmerku 100 mg dvakrat na dan in ketokonazola v odmerku 200 mg enkrat na dan se je plazemska Cmax ketokonazola zvišala za 25 %, vrednosti AUC(0-τ) ketokonazola pa so bile za 2,69-krat višje kot pri uporabi ketokonazola v odmerku 200 mg enkrat na dan brez sočasne uporabe fosamprenavirja z ritonavirjem.
English: There is no data on the efficacy of boosted Agenerase in children.
Slovenian: O uporabi zdravila Agenerase z okrepitvijo pri otrocih ni podatkov.
English: Sixteen of 434 ART-naïve patients who received fosamprenavir 700mg/ritonavir 100mg twice daily in ESS100732 experienced virological failure by Week 48 with 14 isolates genotyped.
Slovenian: V študiji ESS100732 se je pri zdravljenju s fosamprenavirjem 700 mg/ritonavirjem 100 mg dvakrat na dan v 48. tednu virusni neodziv pojavil pri 16 od 434 bolnikov, ki se predhodno še niso zdravili s protiretrovirusnimi zdravili, pri čemer so določili genotip 14 izolatov.
English: When ritonavir is co-administered an increase in clarithromycin concentrations may occur.
Slovenian: Sočasna uporaba ritonavirja lahko vodi do zvišanih koncentracij klaritromicina.
English: These results imply that young animals lack fully developed metabolic pathways enabling them to excrete amprenavir or some critical components of the formulation (e.g. propylene glycol, PEG 400).
Slovenian: Dobljeni rezultati kažejo, da se pri mladičih, katerih presnovne poti še niso docela razvite, amprenavir ali nekatere druge sestavine zdravila (npr. propilenglikol, PEG 400) niso mogli izločati.
English: In long-term carcinogenicity studies with amprenavir in mice and rats, there were benign hepatocellular adenomas in males at exposure levels equivalent to 2.0-fold (mice) or 3.8-fold (rats) those in humans given 1200 mg twice daily of amprenavir alone.
Slovenian: V dolgotrajnih študijah kancerogenega potenciala amprenavirja na miših in podganah je pri samcih ob izpostavi odmerkom, ekvivalentnim 2,0-kratnim (miši) ali 3,8-kratnim (podgane) odmerkom, ki se dajejo človeku (1200 mg amprenavirja samega dvakrat dnevno), prihajalo do benignih hepatocelularnih adenomov.
English: Hyperbilirubinaemia
Slovenian: hiperbilirubinemija
English: It is therefore recommended that mothers being treated with Agenerase do not breast-feed their infants.
Slovenian: V primeru zdravljenja z zdravilom Agenerase je priporočljivo, da matere otrok ne dojijo.
English: Herbal preparations containing St John's wort should therefore not be combined with Agenerase.
Slovenian: Rastlinski pripravki iz šentjanževke se torej ne smejo kombinirati z zdravilom Agenerase.
English: Agenerase is administered orally and can be taken with or without food.
Slovenian: Peroralna raztopina Agenerase se uporablja peroralno in se sme jemati s hrano ali brez nje.
English: Therefore, interactions with amprenavir due to protein binding displacement are highly unlikely.
Slovenian: Zato je zelo malo verjetno, da bi zaradi izpodrivanja z vezavnih mest na proteinih pri jemanju amprenavirja prišlo do medsebojnega delovanja z drugimi zdravili.
English: Herbal preparations containing St John's wort (Hypericum perforatum) must not be used while taking amprenavir due to the risk of decreased plasma concentrations and reduced clinical effects of amprenavir (see section 4.5).
Slovenian: Zeliščni pripravki s šentjanževko (Hypericum perforatum) se zaradi nevarnosti znižanja plazemskih koncentracij in manjše klinične učinkovitosti amprenavirja ne smejo uporabljati sočasno z amprenavirjem (glejte poglavje 4.5).
English: Renal impairment: no dose adjustment is considered necessary in patients with renal impairment (see section 5.2).
Slovenian: Oslabljeno delovanje ledvic: Pri bolnikih z oslabljenim delovanjem ledvic odmerka ni potrebno prilagoditi (glejte poglavje 5.2).
English: Should this happen to you, seek immediate advice from your doctor.
Slovenian: V takšnem primeru se nemudoma posvetujte s svojim zdravnikom.
English: Amprenavir is 14 % less bioavailable from the oral solution than from the capsules; therefore, Agenerase capsules and Agenerase oral solution are not interchangeable on a milligram per milligram basis.
Slovenian: Biološka uporabnost amprenavirja v peroralni raztopini je za 14 % manjša kot v kapsulah, zato kapsule Agenerase in peroralna raztopina Agenerase nista zamenljivi v enakih miligramskih odmerkih.
English: The benefit of Agenerase oral solution boosted with ritonavir has not been demonstrated either in protease inhibitor naïve patients or protease inhibitor experienced patients.
Slovenian: Korist uporabe peroralne raztopine Agenerase, okrepljene z ritonavirjem, ni bila dokazana niti pri bolnikih, ki se predhodno še niso zdravili z zaviralci proteaz, niti bolnikih, ki so se že zdravili z zaviralci proteaz.
English: To derive the full benefit of Agenerase, it is very important that you take the full daily dose prescribed by your doctor.
Slovenian: Zelo pomembno je, da vzamete celoten dnevni odmerek, ki vam ga je predpisal zdravnik, saj se le tako lahko doseže popolna korist zdravila Agenerase.
English: Genotypic interpretation systems may be used to estimate the activity of amprenavir / ritonavir or fosamprenavir / ritonavir in subjects with PI-resistant isolates.
Slovenian: Za ocenjevanje delovanja amprenavirja / ritonavirja ali fosamprenavirja / ritonavirja pri osebah z izolati, odpornimi na zaviralce proteaz, se lahko uporabijo genotipski interpretacijski sistemi.
English: Very common side effects (these can affect more than 10 in 100 patients treated)
Slovenian: Zelo pogosti neželeni učinki (ki se lahko pojavijo pri več kot 10 od 100 zdravljenih bolnikov)
English: CYP3A4 substrates with narrow therapeutic index Agenerase must not be administered concurrently with medicinal products with narrow therapeutic windows containing active substances that are substrates of cytochrome P450 3A4 (CYP3A4).
Slovenian: Substrati za CYP3A4 z ozkim terapevtskim indeksom Zdravilo Agenerase se ne sme dajati sočasno z zdravili z ozko terapevtsko širino, ki vsebujejo učinkovine, ki so substrati za citokrom P450 3A4 (CYP3A4).
English: MANUFACTURING AUTHORISATION HOLDERS RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IMETNIK(I) DOVOLJENJA ZA IZDELAVO ZDRAVILA, ODGOVOREN (ODGOVORNI) ZA SPROŠČANJE SERIJE
English: The pharmacokinetics, efficacy and safety of Agenerase in combination with low doses of ritonavir or other protease inhibitors have not yet been evaluated in children.
Slovenian: Farmakokinetične lastnosti, učinkovitost in varnost zdravila Agenerase v kombinaciji z nizkimi odmerki ritonavirja ali z drugimi zaviralci proteaz pri otrocih še niso bile ovrednotene, zato se je takšnim kombinacijam pri otrocih potrebno izogibati.
English: Adverse reactions are listed below by MedDRA body system organ class and by frequency.
Slovenian: Neželeni učinki so navedeni po organskih sistemih in po pogostnosti glede na MedDRA podatkovno bazo.
English: Amprenavir is primarily metabolised in the liver by CYP3A4.
Slovenian: Amprenavir se primarno presnavlja v jetrih s CYP3A4.
English: Agenerase in combination with ritonavir is contraindicated in patients with severe hepatic impairment.
Slovenian: Zdravilo Agenerase je v kombinaciji z ritonavirjem kontraindicirano pri bolnikih s hudo obliko oslabljenega delovanja jeter.
English: The other ingredients within the capsule are d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), macrogol 400 (polyethylene glycol 400) and propylene glycol.
Slovenian: Pomožne snovi vsebine kapsule so: D-α-tokoferilpolietilenglikol 1000 sukcinat (TPGS), makrogol 400 (polietilenglikol 400) in propilenglikol.
English: These include substances such as: clozapine, cimetidine, dapsone and loratadine.
Slovenian: Druge učinkovine: Amprenavir lahko zviša plazemske koncentracije drugih zdravilnih učinkovin, kot so: klozapin, cimetidin, dapson in loratadin.
English: The AUC, Cmax and Cmin of amprenavir were increased by 130%, 40% and 125% respectively.
Slovenian: AUC, Cmax in Cmin amprenavirja so se zvečale: AUC za 130 %, Cmax za 40 % in Cmin za 125 %.
English: Amprenavir was not mutagenic or genotoxic in a battery of in vivo and in vitro genetic toxicity assays, including bacterial reverse mutation (Ames Test), mouse lymphoma, rat micronucleus, and chromosome aberration in human peripheral lymphocytes.
Slovenian: Z in vitro in in vivo testi genotoksičnosti, vključno z bakterijsko reverzno mutacijo (Ames test), mišjimi limfomi, s podganjimi mikronukleusi in kromosomsko aberacijo na humanih perifernih limfocitih, je bilo ugotovljeno, da amprenavir ni mutagen ali genotoksičen.
English: Agenerase oral solution should not be used in patients with hepatic impairment or failure (see section 4.3).
Slovenian: Peroralna raztopina Agenerase se ne sme uporabljati pri bolnikih z oslabljenim delovanjem ali odpovedjo jeter (glejte poglavje 4.3).
English: The choice of Agenerase will be based on any resistance testing your doctor may have carried out and your treatment history.
Slovenian: Zdravnik bo/je zdravilo Agenerase izbral na osnovi testov odpornosti virusa in na osnovi podatkov o vašem predhodnem zdravljenju.
English: Do not store above 30°C.
Slovenian: Shranjujte pri temperaturi do 30 ºC.
English: Caution must also be exercised if Agenerase is used concurrently with atorvastatin, which is metabolized to a lesser extent by CYP3A4.
Slovenian: Previdnost je potrebna tudi ob sočasni uporabi zdravila Agenerase in atorvastatina, presnova slednjega je sicer manj odvisna od CYP3A4.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Agenerase oral solution contains 15 mg/ml of amprenavir.
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Peroralna raztopina Agenerase vsebuje 15 mg/ml amprenavirja.
English: Children (4 to 12 years) and patients less than 50 kg body weight: the recommended dose of Agenerase capsules is 20 mg/kg body weight twice a day, in combination with other antiretroviral agents, without exceeding a total daily dose of 2400 mg (see section 5.1).
Slovenian: Otroci (4 do 12 let) in bolniki s telesno maso, manjšo od 50 kg: V kombinaciji z drugimi protiretrovirusnimi zdravili je priporočen odmerek kapsul Agenerase 20 mg/kg telesne mase dvakrat dnevno, skupni dnevni odmerek pa ne sme presegati 2400 mg (glejte poglavje 5.1).
English: Do not store above 30o C. Keep the container tightly closed, in order to protect from moisture.
Slovenian: Za zagotovitev zaščite pred vlago shranjujte vsebnik tesno zaprt.
English: Early discontinuation of failing therapies is recommended in order to limit the accumulation of multiple mutations, which may be detrimental to a subsequent rescue regimen.
Slovenian: Da bi omejili kopičenje multiplih mutacij, ki so lahko odgovorne za neuspeh nadaljnjega zdravljenja, je priporočljiva zgodnja ukinitev neučinkovitih zdravljenj.
English: This product contains glycerol, sorbitol E420 and propylene glycol See leaflet for further information
Slovenian: To zdravilo vsebuje glicerol, sorbitol (E420) in propilenglikol.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains 150 mg amprenavir.
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Vsaka kapsula vsebuje 150 mg amprenavirja.
English: Deutschland GlaxoSmithKline GmbH & Co. KG
Slovenian: • Glaxo Wellcome GmbH & Co. KG.
English: Do not take Agenerase if you are allergic (hypersensitive) to amprenavir or to any of the other ingredients in
Slovenian: KAJ MORATE VEDETI, PREDEN BOSTE VZELI ZDRAVILO AGENERASE Ne jemljite zdravila Agenerase - če ste alergični na (preobčutljivi za) amprenavir ali katero koli drugo sestavino zdravila
English: - bepridil (used to treat hypertension).
Slovenian: bepridil (uporabljamo ga za zdravljenje povišanega krvnega tlaka).
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains 50 mg of amprenavir.
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Vsaka kapsula vsebuje 50 mg amprenavirja.
English: Therefore, if efavirenz is given in combination with amprenavir (600 mg twice daily) and ritonavir (100 mg twice daily), no dose adjustment is necessary.
Slovenian: Glede na to prilagajanje odmerkov ni potrebno, če se efavirenz daje v kombinaciji z amprenavirjem (600 mg dvakrat dnevno) in ritonavirjem (100 mg dvakrat dnevno).
English: The benefit of Agenerase oral solution boosted with ritonavir has not been demonstrated either in PI naïve patients or in PI experienced patients.
Slovenian: Korist uporabe peroralne raztopine Agenerase, okrepljene z ritonavirjem, ni bila dokazana niti pri bolnikih, ki se predhodno še niso zdravili s PI-ji, niti bolnikih, ki so se že zdravili s PI-ji.
English: Agenerase oral solution should be used with caution if you have limited liver enzyme activity, kidney impairment or a genetically lower ability to metabolise alcohol (e.g. Asian origin) due to adverse reactions that may be related to the propylene glycol in the solution.
Slovenian: V primeru zmanjšane aktivnosti jetrnih encimov, oslabljenega delovanja ledvic ali genetsko zmanjšane zmožnosti presnove alkohola (če ste npr. azijskega porekla) morate zaradi možnih neželenih učinkov, povezanih s propilenglikolom v raztopini, peroralno raztopino Agenerase uporabljati previdno.
English: In PI experienced patients receiving Agenerase capsules 600 mg twice daily and low dose ritonavir, 100 mg twice daily, the nature and frequency of adverse events (grade 2-4) and Grade 3/4 laboratory abnormalities were similar to those observed with Agenerase alone, with the exception of elevated triglyceride levels, and elevated CPK levels which were very common in patients receiving Agenerase and low dose ritonavir.
Slovenian: Pri bolnikih, ki so že bili zdravljeni s PI-ji in so prejemali kapsule Agenerase v odmerku 600 mg dvakrat dnevno in ritonavir v nizkem odmerku 100 mg dvakrat dnevno, sta bili vrsta in pogostnost neželenih učinkov (stopnje 2-4) ter laboratorijskih odstopanj stopnje 3-4 podobni tistim, ki so jih opazili pri bolnikih, ki so prejemali samo zdravilo Agenerase.
English: Amprenavir is 14 % less bioavailable from the oral solution than from the capsules; therefore, Agenerase capsules and Agenerase oral solution are not interchangeable on a milligram per milligram basis (see section 5.2).
Slovenian: Biološka uporabnost amprenavirja v peroralni raztopini je za 14 % manjša kot v kapsulah, zato kapsule Agenerase in peroralna raztopina Agenerase niso zamenljive v enakih miligramskih odmerkih (glejte poglavje 5.2).
English: Hepatic impairment: the pharmacokinetics of amprenavir are significantly altered in patients with moderate to severe hepatic impairment.
Slovenian: Oslabljeno delovanje jeter: Pri bolnikih z zmerno do hujšo obliko oslabljenega delovanja jeter se farmakokinetične lastnosti amprenavirja znatno spremenijo.
English: Based on data from twenty-five antiretroviral naïve patients failing a fosamprenavir containing regimen (one of whom showed Baseline resistance to lopinavir and saquinavir and another to tipranavir) the resistance pathways associated with amprenavir produce limited cross-resistance to atazanavir/ritonavir (three of 25 isolates), darunavir/ritonavir (four of 25 isolates), indinavir/ritonavir (one of 25 isolates), lopinavir/ritonavir (three of 24 isolates), saquinavir (three of 24 isolates) and tipranavir/ritonavir (four of 24 isolates).. Conversely amprenavir retains activity against some isolates with resistance to other PIs and this retained activity would depend on the number and type of protease resistance mutations present in the isolates.
Slovenian: Na osnovi podatkov, pridobljenih pri petindvajsetih bolnikih, ki predhodno še niso bili zdravljeni s protiretrovirusnimi zdravili in pri katerih je bilo zdravljenje z režimom, ki je vključeval fosamprenavir neuspešno (pri enem od njih je bila v izhodišču prisotna odpornost na lopinavir in sakvinavir, pri enem pa na tipranavir), mehanizem rezistence, povezan z amprenavirjem, povzroča omejeno navzkrižno rezistenco na atazanavir/ritonavir (trije od 25 izolatov), darunavir/ritonavir (štirje od 25 izolatov), indinavir/ritonavir (eden od 25 izolatov), lopinavir/ritonavir (trije od 24 izolatov), sakvinavir (trije od 24 izolatov) in tipranavir/ritonavir (štirje od 24 izolatov).
English: Tricyclic antidepressants: careful monitoring of the therapeutic and adverse reactions of tricyclic antidepressants is recommended when they (for example desipramine and nortriptyline) are concomitantly administered with Agenerase (see section 4.4).
Slovenian: Triciklični antidepresivi: Pri sočasnem zdravljenju z zdravilom Agenerase in tricikličnimi antidepresivi (npr. dezipramin, nortriptilin) priporočamo skrbno nadziranje terapevtskih učinkov in neželenih reakcij tricikličnih antidepresivov (glejte poglavje 4.4).
English: What Agenerase looks like and contents of the pack Agenerase 50 mg soft capsules are supplied in plastic bottles containing 480 soft capsules.
Slovenian: Zdravilo Agenerase v obliki 50 mg mehkih kapsul je na voljo v plastenkah, ki vsebujejo 480 mehkih kapsul.
English: An oral solution of Agenerase is available for children or adults unable to swallow capsules.
Slovenian: Za otroke in odrasle, ki ne morejo pogoltniti kapsul, je na voljo peroralna raztopina Agenerase.