FrancophonIA/ELRC3.0 huggingface dataset:
English: ANTI-INFECTIVE PRODUCTS Trimethoprim/sulfamethoxazole (Co-trimoxazole)/Abacavir
Danish: LÆGEMIDLER MOD INFEKTIONER Trimethoprim/sulfamethoxazol (sulfa/trim) / abacavir
English: The exception was the preputial gland tumour which occurred at a dose of 110 mg/kg in mice.
Danish: Tumorer i forhudskirtlen opstod dog ved en dosis på 110 mg/kg hos mus.
English: These may affect up to 1 in 10,000 people:
Danish: Disse kan forekomme hos op til 1 ud af 10.000 personer:
English: Common: Cough, nasal symptoms
Danish: Almindelig: Hoste, symptomer fra næse
English: The Kivexa pack includes an Alert Card, to remind you and medical staff about abacavir hypersensitivity.
Danish: Der er vedlagt et oplysningskort i pakningen med Kivexa for at gøre dig og sundhedspersonalet opmærksom på overfølsomhed over for abacavir.
English: The inclusion of zidovudine in the regimen has been found to reduce the frequency of L74V and K65R selection in the presence of abacavir (with zidovudine: 0/40, without zidovudine: 15/192, 8%).
Danish: Når zidovudin inkluderes i behandlingen med abacavir, reduceres forekomsten af L74V- og K65Rmutationerne (med zidovudin: 0/40, uden zidovudin: 15/192, 8 %).
English: Some medicines interact with Kivexa These include:
Danish: Nogle lægemidler kan påvirke Kivexas virkning og omvendt Disse omfatter:
English: This recurrence of the HSR is usually more severe than on initial presentation, and may include lifethreatening hypotension and death.
Danish: Denne tilbagevenden af overfølsomhedsreaktionen er som regel alvorligere end den initiale reaktion og kan indebære livstruende hypotension og død.
English: The mean EC50 against laboratory strains of HIV-2 (LAV2 and EHO) ranged from 1.57 to 7.5 µM for abacavir and from 0.16 to 0.51 µM for lamivudine.
Danish: Den gennemsnitlige EC50 mod laboratoriestammer af hiv-2 (LAV2 og EHO) lå i intervallet 1,57 - 7,5 M for abacavir og 0,16 - 0,51 M for lamivudin.
English: Contact your doctor immediately: 1 if you get a skin rash, OR 2 if you get symptoms from at least 2 of the following groups: fever shortness of breath, sore throat or cough nausea or vomiting, diarrhoea or abdominal pain severe tiredness or achiness, or generally feeling ill.
Danish: Kontakt lægen omgående: 1 hvis du får udslæt ELLER 2 hvis du får et eller flere symptomer fra mindst 2 af de følgende grupper: feber åndenød, ondt i halsen eller hoste kvalme, opkastning, diarré eller mavesmerter udtalt træthed eller smerter eller generel følelse af at være syg.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/04/298/003
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/04/298/003
English: What Kivexa looks like and contents of the pack Kivexa film-coated tablets are engraved with ‘GS FC2' on one side.
Danish: Kivexa filmovertrukne tabletter er præget med 'GS FC2' på den ene side.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Danish: Særligt hos patienter med generelt anerkendte risikofaktorer, fremskreden hiv-sygdom eller langvarig CART-behandling er der rapporteret om tilfælde af osteonekrose.
English: If you notice any of these symptoms contact a doctor urgently.
Danish: Hvis du bemærker et eller flere af disse symptomer: Tal med lægen.
English: Rarely, patients who have stopped abacavir for reasons other than symptoms of HSR have also experienced life-threatening reactions within hours of re- initiating abacavir therapy (see Section 4.8 Description of selected adverse reactions).
Danish: I sjældne tilfælde oplever patienter, der er stoppet behandling med abacavir af andre grunde end symptomer på en overfølsomhedsreaktion, også livstruende reaktioner indenfor timer efter genoptagelse af abacavir-behandling (se pkt.
English: There have been reports of mitochondrial dysfunction in HIVnegative infants exposed in utero and/or post-natally to nucleoside analogues (see section 4.4).
Danish: Der foreligger rapporter om mitokondriel dysfunktion hos hiv-negative spædbørn, som har været eksponeret for nukleosidanaloger in utero og/eller efter fødslen (se pkt.
English: Pharmacokinetic data has been obtained for abacavir and lamivudine separately.
Danish: Farmakokinetiske data foreligger separat for abacavir og lamivudin.
English: 30 tablets in opaque white (PVC/PVDCAluminium/Paper) child-resistant blister packs Multipacks containing 90 (3 packs of 30) tablets in opaque white (PVC/PVDC-Aluminium/Paper) child-resistant blister packs.
Danish: Multipakninger indeholdende 90 (3 pakker med 30) tabletter i uigennemsigtige hvide (PVC/PVDC/aluminium/papir) børnesikrede blisterpakninger.
English: Placental transfer of abacavir and lamivudine has been shown to occur in humans.
Danish: Der er set tilfælde af transplacental overførsel af abacavir og lamivudin hos mennesker.
English: The Kivexa pack includes an Alert Card, to remind you and medical staff about hypersensitivity reactions.
Danish: Der er vedlagt et oplysningskort i pakningen med Kivexa for at gøre dig og sundhedspersonalet opmærksom på overfølsomhedsreaktioner over for abacavir.
English: Before initiating abacavir therapy, clinicians should screen for HLA-B*5701 .
Danish: Før opstart af behandling med abacavir, skal læger overveje screening for HLA-B*5701.
English: The M184V or M184I variants arise in HIV-1 infected patients treated with lamivudine-containing antiretroviral therapy and confer high-level resistance to lamivudine.
Danish: M184V- eller M1841-varianterne opstår hos hiv-1-positive patienter, der er behandlet med lamivudinholdige antiretroviraler og giver høj resistens over for lamivudin.
English: • lactic acidosis (excess lactic acid in the blood)
Danish: • for meget mælkesyre i blodet (laktacidose).
English: Among the 669 subjects randomized in this study (from 12 months to ≤17 years old), the abacavir/lamivudine once daily dosing group was demonstrated to be non-inferior to the twice daily group according to the pre-specified non-inferiority margin of -12%, for the primary endpoint of <80 c/mL at Week 48 as well as at Week 96 (secondary endpoint) and all other thresholds tested (<200c/mL, <400c/mL, <1000c/mL), which all fell well within this non-inferiority margin.
Danish: Blandt de 669 randomiserede patienter (alder fra 12 måneder til ≤ 17 år) blev det påvist, at gruppen, som fik abacavir/lamivudin 1 gang daglig, var non-inferior til gruppen doseret 2 gange daglig, i henhold til den præ-definerede non-inferioritetsmargen på -12 %, for det primære endepunkt på < 80 c/ml ved uge 48 såvel som ved uge 96 (sekundært endepunkt).
English: Proposed actions: Provision of updated ABC HSR education materials for healthcare professionals to countries where the MAH has marketing authorisation for ABC.
Danish: Foreslåede handlinger: Levering af opdateret uddannelsesmateriale for ABC-overfølsomhedsreaktion til sundhedspersonalet i lande hvor MAH har markedsføringstilladelse til ABC Kriterier, som skal benyttes til at verificere succesen af de foreslåede risikominimeringsaktiviteter: Implementering af uddannelsesprogrammet vil blive monitoreret af MAH via auditering.
English: Abacavir should not be used in patients known to carry the HLA-B*5701 allele.
Danish: Abacavir må ikke anvendes til patienter, der bærer HLA-B*5701-allel.
English: Zidovudine/Lamivudine Zidovudine 300 mg single dose Lamivudine 150 mg single dose
Danish: Zidovudin / lamivudin Zidovudin 300 mg enkeltdosis Lamivudin 150 mg enkeltdosis
English: Baseline Reverse Transcriptase Mutation
Danish: Revers transkriptasemutation ved baseline
English: Fever, lethargy, malaise, oedema, lymphadenopathy, hypotension, conjunctivitis, anaphylaxis
Danish: Feber, svær udmatning, utilpashed, ødem, lymfadenopati, hypotension, konjunktivitis, anafylaksi
English: Studies in patients with renal impairment show lamivudine elimination is affected by renal dysfunction.
Danish: Undersøgelser af patienter med nedsat nyrefunktion viser, at elimination af lamivudin påvirkes ved nyreinsufficiens.
English: The symptoms related to HSR worsen with continued therapy and can be life-threatening.
Danish: Symptomerne i forbindelse med en overfølsomhedsreaktion forværres ved fortsat behandling og kan være livstruende.
English: For lamivudine, the EC50 values against HIV-1 subtypes (A-G) ranged from 0.001 to 0.170 µM, against Group O from 0.030 to 0.160 µM and against HIV-2 isolates from 0.002 to 0.120 µM in peripheral blood mononuclear cells.
Danish: For lamivudin lå EC50-værdierne mod hiv-1-subtyper (A-G) i intervallet 0,001 - 0,170 M, mod gruppe O i intervallet 0,030 - 0,160 M og mod hiv-2-isolater i intervallet 0,002 - 0,120 M i perifere mononukleære blodceller.
English: Virologic Response Based on Plasma HIV-1 RNA < 50 copies/ml ITT-Exposed Population M=F switch included
Danish: Virologisk respons baseret på plasma-hiv-1-RNA < 50 kopier/ml ved uge 48 ITT-eksponeret population, ”Missing = Failure switch” inkluderet
English: How to take Kivexa
Danish: Sådan skal du tage Kivexa
English: Separate preparations of abacavir or lamivudine are available in cases where discontinuation or dose adjustment of one of the active substances is indicated.
Danish: I tilfælde, hvor ophør med eller dosisjustering af en af de aktive substanser er indikeret, er separate præparater med abacavir eller lamivudin tilgængelige.
English: If you have stopped taking Kivexa If you have stopped taking Kivexa for any reason - especially because you think you are having side effects, or because you have other illness: Talk to your doctor before you start taking it again.
Danish: Hvis du er holdt op med at tage Kivexa af en eller anden grund - særligt hvis det er fordi, du mener, at du får bivirkninger, eller fordi du har en anden sygdom:
English: Antiviral therapy According to Genotypic/Phenotypic Resistance
Danish: Antiviral behandling efter genotype/fænotype resistens
English: In study CAL30001, 182 treatment-experienced patients with virologic failure were randomised and received treatment with either Kivexa once daily or abacavir 300 mg twice daily plus lamivudine 300 mg once daily, both in combination with tenofovir and a PI or an NNRTI for 48 weeks.
Danish: I studiet CAL30001 blev 182 tidligere behandlede patienter med virologisk svigt randomiseret, og de fik enten Kivexa én gang daglig eller abacavir 300 mg 2 gange daglig plus lamivudin 300 mg én gang daglig, begge i kombination med tenofovir og en PI eller en NNRTI i 48 uger.
English: Delay in stopping treatment with Kivexa after the onset of hypersensitivity may result in a life-threatening reaction.
Danish: Forsinkelse i seponering af Kivexa efter indtrædelse af en overfølsomhedsreaktion kan resultere i en livstruende situation.
English: The M184V or M184I variants arise in HIV-1 infected patients treated with lamivudine-containing antiretroviral therapy.
Danish: M184V- eller M1841-varianter opstår hos hiv-1-positive patienter, der behandles med lamivudin-holdige antiretroviraler.
English: They are orange and capsuleshaped and are provided in blister packs containing 30 tablets and multipack blister packs containing 90(3 x 30) tablets.
Danish: De fås i blisterpakninger med 30 tabletter og i multiblisterpakninger med 90 (3x30) tabletter.
English: Dyspnoea, cough, sore throat, adult respiratory distress syndrome, respiratory failure
Danish: Åndenød, hoste, ondt i halsen, akut respiratorisk distress syndrom, respirationssvigt
English: Animal studies with lamivudine showed an increase in early embryonic deaths in rabbits but not in rats.
Danish: Dyrestudier med lamivudin har vist en stigning i tidlig fosterdød hos kaniner, men ikke hos rotter (se pkt.
English: Abacavir is primarily metabolised by the liver with approximately 2% of the administered dose being renally excreted, as unchanged compound.
Danish: Abacavir metaboliseres hovedsageligt i leveren, og ca. 2 % af den administrerede dosis udskilles uomdannet via nyrerne.
English: L74V Y115F M184V/I TAMs3
Danish: M184V/I
English: Single dose lamivudine oral solution 300 mg
Danish: Enkelt dosis lamivudin oral opløsning 300 mg Lamivudin:
English: Diagnosis of Abacavir Hypersensitivity Reaction
Danish: Diagnosticering af abacavir overfølsomhedsreaktion
English: As a general rule, when deciding to use antiretroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account.
Danish: Overordnet skal data fra dyreforsøg såvel som klinisk erfaring fra gravide medtages i overvejelserne ved beslutning om, hvorvidt antiretrovirale lægemidler skal anvendes i behandlingen af hiv-infektion hos gravide for at nedsætte risikoen for vertikal transmission af hiv til den nyfødte.
English: You should have been tested for this gene before Kivexa was prescribed for you.
Danish: Du skal derfor undersøges for, om du har dette gen, inden lægen ordinerer Kivexa.
English: GlaxoSmithKline (Malta) Limited Tel: + 356 21 238131
Danish: GlaxoSmithKline Malta Tel: + 356 21 238131
English: Before initiating treatment with abacavir, screening for carriage of the HLA-B*5701 allele should be performed in any HIV-infected patient, irrespective of racial origin (see section 4.4).
Danish: Før initiering af behandling med abacavir skal alle hiv-patienter, uanset raceoprindelse, screenes for eventuelt at være bærer af HLA-B*5701-allel (se pkt.
English: Therapy-experienced patients
Danish: Behandlingserfarne patienter
English: Do not store above 30°C.
Danish: Må ikke opbevares ved temperaturer over 30 ◦C.
English: • high doses of trimethoprim/sulfamethoxazole, an antibiotic
Danish: • høje doser af sulfamethoxazol/trimethoprim, til behandling af bakterieinfektioner.
English: ANTICONVULSANTS Phenobarbital/Abacavir
Danish: ANTIKONVULSIVA Phenobarbital / abacavir
English: Rare: pancreatitis has been reported, but a causal relationship to abacavir treatment is uncertain
Danish: Almindelig: Kvalme, opkastning, diarré Sjælden: Pancreatitis er rapporteret, men kausale relationer til abacavir behandling er usikre
English: Baseline RNA category <100,000 copies/mL
Danish: Baseline-RNA-kategori <100,000 kopier/ml
English: These findings should be considered for any child exposed in utero to nucleotide and nucleotide analogues, who presents with severe clinical findings of unknown etiology, particularly neurologic findings..
Danish: Mitokondriel dysfunktion bør overvejes hos alle børn med svære kliniske symptomer af ukendt ætiologi, især neurologiske symptomer, der har været eksponeret for nukleosid-/nukleotid-analoger in utero.
English: A genotypic sensitivity score (GSS) has not been established by the MAH for the abacavir/lamivudine combination.
Danish: En genotypisk sensitivitetsscore (GSS) for kombination af abacavir og lamivudin er ikke fastlagt af indehaveren af markedsføringstilladelsen.
English: Symptoms of infection and inflammation
Danish: Symptomer på infektion eller betændelseslignende reaktioner (inflammation)
English: Abacavir is metabolised primarily by the liver.
Danish: Abacavir metaboliseres primært i leveren.
English: Proportion of Patients in CAL30001 with <50 copies/mL at Week 48 by Genotypic Sensitivity Score in OBT and Number of Baseline Mutations
Danish: Andel af patienter i CAL30001 med < 50 kopier/ml ved uge 48 efter genotypisk sensitivitetsscore i OBT og antal mutationer ved baseline
English: Baseline CD4 category 201-350 101/143 (71%)
Danish: Baseline-CD4-kategori 201-350 101/143 (71 %) 114/170 (67 %)
English: CYTOTOXICS Cladribine/Lamivudine
Danish: CYTOTOKSISKE LÆGEMIDLER Cladribin/Lamivudin
English: The EC50 values of abacavir against HIV-1 Group M subtypes (A-G) ranged from 0.002 to 1.179 µM, against Group O from 0.022 to 1.21 µM, and against HIV-2 isolates, from 0.024 to 0.49 µM.
Danish: EC50-værdier for abacavir mod gruppe M hiv-1-subtyper (A-G) lå i intervallet 0,002 - 1,179 M, mod gruppe O i intervallet 0,022 - 1,21 M og mod hiv-2-isolater i intervallet 0,024 - 0,49 M.
English: Restarting abacavir following an abacavir HSR results in a prompt return of symptoms within hours.
Danish: Genoptagelse af behandling med abacavir efter en overfølsomhedsreaktion resulterer i, at symptomerne omgående vender tilbage (inden for timer).
English: Delay in stopping treatment with abacavir after the onset of hypersensitivity may result in an immediate and life-threatening reaction.
Danish: Efter påbegyndt overfølsomhed kan forsinket stop i behandlingen med abacavir resultere i en hurtigt indtrædende og livstruende reaktion.
English: Abacavir is primarily metabolised by the liver with approximately 2% of abacavir excreted unchanged in the urine.
Danish: Abacavir metaboliseres primært i leveren, og ca. 2 % abacavir udskilles uomdannet i urinen.
English: ANTIMYCOBACTERIALS Rifampicin/Abacavir
Danish: ANTIMYKOTIKA Rifampicin / abacavir
English: • After stopping treatment with Kivexa for reasons of a suspected HSR, Kivexa or any other medicinal product containing abacavir (e.g. Ziagen, Trizivir, Triumeq) must never be reinitiated.
Danish: • Efter seponering af Kivexa grundet formodet overfølsomhedsreaktion må behandling med Kivexa eller andre lægemidler, som indeholder abacavir (f.eks. Ziagen, Trizivir, Triumeq), aldrig genoptages.
English: Methadone dosage adjustment unlikely in majority of patients; occasionally methadone re-titration may be required.
Danish: Dosisjustering af methadon forventes ikke at være nødvendig for størsteparten af patienterne.
English: If you have stopped taking Kivexa because of a hypersensitivity reaction, you must NEVER AGAIN take Kivexa, or any other medicine containing abacavir (e.g. Trizivir, Triumeq or Ziagen).
Danish: Hvis du holder op med at tage Kivexa på grund af en overfølsomhedsreaktion, må du ALDRIG MERE tage Kivexa eller anden medicin, der indeholder abacavir (f.eks. Trizivir, Triumeq eller Ziagen).
English: The overall selection frequency for M184V or M184I was high (54%), and less common was the selection of L74V (5%), K65R (1%) and Y115F (1%) (see table below).
Danish: Mindre almindelige var mutationerne L74V (5 %), K65R (1 %) og Y115F (1 %) (se tabel nedenfor).
English: Many of the adverse reactions listed in the table below occur commonly (nausea, vomiting, diarrhoea, fever, lethargy, rash) in patients with abacavir hypersensitivity.
Danish: En del af de bivirkninger, der er nævnt i tabellen nedenfor, er almindelige hos patienter med overfølsomhed over for abacavir (kvalme, opkastning, diarré, feber, svær udmatning, udslæt).
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorization: 17 December 2004
Danish: DATO FOR FØRSTE MARKEDSFØRINGSTILLADELSE/FORNYELSE AF TILLADELSEN
English: Abacavir is associated with a risk for hypersensitivity reactions (HSR) (see section4.8) ) characterised by fever and/or rash with other symptoms indicating multi-organ involvement.
Danish: 4.8), karakteriseret ved feber og/eller udslæt med andre symptomer, som indikerer multiorganinvolvering.
English: Kivexa is not recommended for use in patients with a creatinine clearance < 50 ml/min as necessary dose adjustment cannot be made (see section 4.2).
Danish: Kivexa er ikke anbefalet til brug hos patienter med en kreatininclearance < 50 ml/min, da nødvendig dosisjustering ikke er mulig (se pkt.
English: Excipient(s) with known effect: sunset yellow FCF (E110) 1.7 mg per tablet For the full list of excipients see section 6.1.
Danish: Hjælpestoffer, som behandleren skal være opmærksom på: sunset yellow FCF (E110) 1,7 mg pr. tablet.
English: • hypersensitivity reaction
Danish: • overfølsomhedsreaktioner
English: CNA109586 (ASSERT study), a multi-centre, open label, randomised study of abacavir/lamivudine (ABC/3TC, 600mg/300mg) and tenofovir/emtricitabine (TDF/FTC, 300mg/200mg), each given once daily with efavirenz (EFV, 600mg) in ART naïve, HLA-B*5701 negative, HIV-1 infected adults.The virologic results are summarised in the table below:
Danish: Studiet CNA109586 (ASSERT-studiet) var et multicenter, open-label, randomiseret studie af abacavir/lamivudin (ABC/3TC, 600 mg/300 mg) og tenofovir/emtricitabin (TDF/FTC, 300 mg/200 mg), begge administreret én gang daglig i kombination med efavirenz (EFV, 600 mg) hos antiretroviralterapi(ART)-naive, HLA-B*5701-negative, hiv-1-inficerede voksne patienter.
English: RETINOIDS Retinoid compounds (e.g. isotretinoin)/Abacavir
Danish: RETINOIDER Retinoid-forbindelser (f.eks. isotretinoin) / abacavir
English: Proportion of Patients in CNA30021with <50 cps/mL at Week 48 by Genotypic Sensitivity Score in OBT and Number of Baseline Mutations
Danish: Andel af patienter i CNA30021 med < 50 kopier/ml ved uge 48 efter genotypisk sensitivitetsscore i OBT og antal mutationer ved baseline
English: In case of any symptoms suggesting hypersensitivity reactions, contact your doctor IMMEDIATELY “Pull here”
Danish: Kontakt STRAKS din læge i tilfælde af symptomer, der tyder på overfølsomhedsreaktioner ”Træk her”
English: Kivexa is not recommended in patients with moderate or severe hepatic impairment (see sections 4.2 and 5.2).
Danish: Kivexa anbefales ikke hos patienter med moderat eller svært nedsat leverfunktion (se pkt.
English: If overdose occurs the patient should be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Danish: Hvis overdosering finder sted, bør patienten overvåges for tegn på forgiftning (se pkt.
English: Common: Rash, alopecia Rare: Angioedema
Danish: Almindelig: Udslæt, hårtab Sjælden: angioødem
English: Kivexa 600 mg/300 mg film-coated tablets abacavir/lamivudine
Danish: Kivexa 600 mg/300 mg filmovertrukne tabletter abacavir/lamivudin
English: No specific symptoms or signs have been identified following acute overdose with abacavir or lamivudine, apart from those listed as undesirable effects.
Danish: Ud over de beskrevne bivirkninger er ingen specifikke symptomer eller tegn blevet identificeret som følge af akut overdosis med abacavir eller lamivudin.
English: In toxicology studies abacavir was shown to increase liver weights in rats and monkeys.
Danish: I prækliniske toksikologiske undersøgelser blev det påvist, at behandling med abacavir øgede levervægten hos rotter og aber.
English: Opadry Orange YS-1-13065-A containing: hypromellose titanium dioxide macrogol 400 polysorbate 80 sunset yellow FCF (E110)
Danish: Opadry Orange YS-1-13065-A indeholdende: hypromellose titandioxid macrogol 400
English: NAME OF THE MEDICINAL PRODUCT Kivexa 600 mg/300 mg film-coated tablets
Danish: LÆGEMIDLETS NAVN Kivexa 600 mg/300 mg filmovertrukne tabletter
English: • hair loss
Danish: • hårtab.
English: In vitro data tend to suggest that the continuation of lamivudine in anti-retroviral regimen despite the development of M184V might provide residual anti-retroviral activity (likely through impaired viral fitness).
Danish: Ved fremkomst af M184V tyder in vitrodata på, at lamivudin stadig har antiretroviral aktivitet (formentlig på grund af svækkede vira).
English: - If you have any further questions ask your doctor or pharmacist.
Danish: Er du i tvivl, så spørg lægen eller apotekspersonalet.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 600 mg of abacavir (as sulfate) and 300 mg lamivudine.
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING Hver filmovertrukken tablet indeholder 600 mg abacavir (som sulfat) og 300 mg lamivudin.
English: Following discontinuation of abacavir, the symptoms of the reaction should be treated according to local standard of care Rechallenge can result in a more rapid and severe reaction, which can be fatal, therefore rechallenge is contraindicated.
Danish: Genoptagelse af behandlingen kan resultere i en hurtigere og mere alvorlige reaktion, som kan være dødelig, og er derfor kontraindiceret.
English: Pharmacokinetic data have been obtained for lamivudine and abacavir alone.
Danish: Farmakokinetiske data er alene tilgængelige for abacavir og lamivudin.