FrancophonIA/ELRC3.0 huggingface dataset:
English: Kentera is a rapid drying, clear, smooth, odourless, and colourless hydroalcoholic gel that is packaged in single dose sachets.
Croatian: Kentera je brzosušeći, prozirni, glatki, bezmirisni i bezbojni hidroalkoholni gel pakiran u vrećicama za jednokratnu dozu.
English: There is no experience with the use of Kentera in patients with hepatic impairment.
Croatian: Nema iskustva s primjenom Kentere u bolesnika s oštećenjem jetre.
English: - Phenothiazines, butyrophenone or clozapine (used to treat mental illness).
Croatian: - fenotiazini, butirofenon ili klozapin (primjenjuju se za liječenje duševne bolesti)
English: Backing: polyester/ethylene-vinyl acetate film; siliconised polyester film.
Croatian: Potporni sloj: sloj poliester/etilen-vinilacetata; sloj silikoniziranog poliestera.
English: Discard empty sachets and unused product in accordance with local requirements.
Croatian: Zbrinuti prazne vrećice i neiskorišteni lijek sukladno lokalnim propisima.
English: Oxybutynin may slow the digestive tract and thereby influence the adsorption of other oral medicines, or the use of this medicine together with other medicines may increase the effect of oxybutynin.
Croatian: Oksibutinin može usporiti probavni trakt i stoga utjecati na apsorpciju drugih lijekova koji se uzimaju kroz usta (peroralno), ili primjena tog lijeka zajedno s drugim lijekovima može pojačati učinak oksibutinina.
English: EU/1/03/270/001 <8 transdermal patches> EU/1/03/270/002 <24 transdermal patches> EU/1/03/270/003 <2 transdermal patches>
Croatian: EU/1/03/270/001 <8 transdermalnih flastera> EU/1/03/270/001 <24 transdermalna flastera> EU/1/03/270/001 <2 transdermalna flastera>
English: Oxybutynin acts as a competitive antagonist of acetylcholine at post-ganglionic muscarinic receptors, resulting in relaxation of bladder smooth muscle.
Croatian: Oksibutinin djeluje kao kompetitivni antagonist acetilkolina na razini postganglijskih muskarinskih receptora, što rezultira relaksacijom glatkih mišića mjehura.
English: EU/1/03/270/005 1 multidose container with metering pump
Croatian: EU/1/03/270/005 1 višedozni spremnik s odmjernom pumpicom
English: As oxybutynin is metabolised by cytochrome P 450 isoenzyme CYP 3A4, interactions with medicinal products that inhibit this isoenzyme cannot be ruled out.
Croatian: Budući da se oksibutinin metabolizira putem izoenzima CYP3A4 citokroma P450, ne može se isključiti interakcija s lijekovima koji inhibiraju taj izoenzim.
English: The recommended dose is one metered dose from the multidose container with metering pump applied once daily which corresponds to a delivery dose of approximately 4 mg.
Croatian: Preporučena doza je jedna odmjerena doza iz višedoznog spremnika s odmjernom pumpicom primijenjena jedanput dnevno, što odgovara isporučenoj dozi od približno 4 mg.
English: Use with sunscreen
Croatian: Korištenje s preparatima za zaštitu od sunca
English: Each transdermal patch contains 36 mg of oxybutynin.
Croatian: Jedan transdermalni flaster sadrži 36 mg oksibutinina.
English: Avoid bathing, swimming, showering, exercising or immersing the application site in water for one hour after application.
Croatian: Nemojte se kupati, plivati, tuširati, vježbati ili uranjati mjesto primjene u vodu jedan sat nakon primjene.
English: The concomitant use of oxybutynin with other anticholinergic medicinal products or with other active substances that compete for CYP3A4 enzyme metabolism may increase the frequency or severity of dry mouth, constipation, and drowsiness.
Croatian: Istodobna primjena oksibutinina s drugim antikolinergičkim lijekovima ili s drugim djelatnim tvarima koje se natječu za metabolizam enzima CYP3A4 može povećati učestalost ili težinu suhoće usne šupljine, konstipacije i omamljenosti.
English: Placebo)
Croatian: bolesnika placebo).
English: Before using the pump for the first time, you must prime the Kentera pump.
Croatian: 1. korak: Prije prvog korištenja pumpice potrebno je pumpicu Kentera pripremiti.
English: Gastrointestinal disorders: Anticholinergic medicinal products may decrease gastrointestinal motility and should be used with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention.
Croatian: Gastrointestinalni poremećaji: Antikolinergički lijekovi mogu usporiti gastrointestinalni motilitet i potrebno ih je primjenjivati uz oprez u bolesnika s gastrointestinalnim opstruktivnim poremećajima zbog rizika od želučane retencije.
English: Use of oxybutynin is not recommended during breast-feeding.
Croatian: Primjena oksibutinina ne preporučuje se tijekom dojenja.
English: EU/1/03/270/001 8 transdermal patches EU/1/03/270/002 24 transdermal patches EU/1/03/270/003 2 transdermal patches
Croatian: EU/1/03/270/001 8 transdermalnih flastera EU/1/03/270/002 24 transdermalna flastera EU/1/03/270/003 2 transdermalna flastera
English: Abdominal discomfort, dyspepsia
Croatian: Nelagoda u abdomenu, dispepsija
English: Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in adult patients with unstable bladder.
Croatian: Simptomatsko liječenje urgentne inkontinencije i/ili povećane učestalosti mokrenja i urgentnog mokrenja koji se može pojaviti u odraslih bolesnika s nestabilnim mokraćnim mjehurom.
English: If applying Kentera to the stomach, care should be taken to avoid the area around the navel (belly button).
Croatian: Ako primjenjujete Kenteru na trbuh, pazite da je ne stavite na područje oko pupka.
English: Oxybutynin may slow the digestive tract and thereby influence the adsorption of other oral medicines, interfere with bowel movement therapies, and the use of this medicine together with other medicines may increase the effect of oxybutynin.
Croatian: Oksibutinin može usporiti probavni trakt i stoga utjecati na apsorpciju drugih lijekova koji se uzimaju kroz usta (peroralno), utjecati na terapije za pražnjenje crijeva, a primjena tog lijeka zajedno s drugim lijekovima može pojačati učinak oksibutinina.
English: - Overactive thyroid gland which can cause increased appetite, weight loss, or sweating - Narrowing of the blood vessels that supply blood and oxygen to the heart - Heart problems which can cause shortness of breath or ankle swelling - Irregular heart beat - Faster heart beat - High blood pressure - Enlarged prostate
Croatian: - prekomjerno aktivna štitna žlijezda koja može prouzročiti povećani apetit, gubitak tjelesne težine, ili znojenje - sužavanje krvnih žila koje dostavljaju krv i kisik srcu - problemi sa srcem koji mogu prouzročiti nedostatak zraka ili oticanje gležnjeva - nepravilni otkucaji srca - ubrzani otkucaji srca - visok krvni tlak - povećana prostata.
English: Kentera is a rapid drying, clear, smooth, odorless, and colorless hydroalcoholic gel that is packaged in a multidose container with metering pump.
Croatian: Kentera je brzosušeći, prozirni, glatki, bezmirisni i bezbojni hidroalkoholni gel pakiran u višedoznom spremniku s odmjernom pumpicom.
English: During the double-blind treatment a significant positive effect on quality of life was seen with Kentera based on the Incontinence Impact Questionnaire (IIQ).
Croatian: Tijekom dvostruko slijepog liječenja zapažen je značajan pozitivan učinak Kentere na kvalitetu života temeljem
English: There is no experience with the use of Kentera in patients with renal impairment.
Croatian: Nema iskustva s primjenom Kentere u bolesnika s oštećenjem bubrega.
English: Ingestion of 100 mg oral oxybutynin in association with alcohol has been reported in a 13 year old boy who experienced memory loss, and in a 34 year old woman who developed stupor, followed by disorientation and agitation on awakening, dilated pupils, dry skin, cardiac arrhythmia, and retention of urine.
Croatian: Peroralni unos 100 mg oksibutinina zajedno s alkoholom prijavljen je kod 13-godišnjeg dječaka koji je imao gubitak pamćenja te kod 34-godišnje žene kod koje se razvio stupor, nakon čega je uslijedila dezorijentiranost i agitacija pri buđenju, proširene zjenice, suha koža, srčana aritmija i urinarna retencija.
English: Ingestion of 100 mg oral oxybutynin chloride in association with alcohol has been reported in a 13 year old boy who experienced memory loss, and in a 34 year old woman who developed stupor, followed by disorientation and agitation on awakening, dilated pupils, dry skin, cardiac arrhythmia, and retention of urine.
Croatian: Peroralni unos 100 mg oksibutininklorida zajedno s alkoholom prijavljen je kod 13-godišnjeg dječaka koji je imao gubitak pamćenja te kod 34-godišnje žene kod koje se razvio stupor, nakon čega je uslijedila dezorijentiranost i agitacija pri buđenju, proširene zjenice, suha koža, srčana aritmija i urinarna retencija.
English: EU/1/03/270/004 30 sachets
Croatian: EU/1/03/270/004 30 vrećica
English: Patients on Kentera therapy should keep application sites covered with clothing when coming into contact with breast-feeding or pregnant women or breast-fed infants.
Croatian: Bolesnici koji se liječe Kenterom moraju mjesto primjene držati pokriveno odjećom kada dolaze u dodir s dojiljama ili trudnim ženama ili dojenčadi.
English: Anticholinergic medicinal products may potentially alter the absorption of some concomitantly administered medicinal products due to anticholinergic effects on gastrointestinal motility.
Croatian: Antikolinergički lijekovi mogu promijeniti apsorpciju nekih istodobno primijenjenih lijekova zbog antikolinergičkog učinka na gastrointestinalni motilitet.
English: Nonetheless Kentera should be used with caution in elderly patients, who may be more sensitive to the effects of centrally acting anticholinergics and exhibit differences in pharmacokinetics (see section
Croatian: Unatoč tome, Kenteru je potrebno primjenjivati uz oprez u starijih bolesnika, koji mogu biti osjetljiviji na učinke centralno djelujućih antikolinergika i pokazivati razlike u farmakokinetici (vidjeti dio 4.4).
English: Fertility studies in rats suggest a 6-fold margin of safety in both male and female breeding adults when Kentera is administered as prescribed.
Croatian: Ispitivanja plodnosti na štakorima ukazuju na šesterostruku granicu sigurnosti u plodnih odraslih muškarca i žena kada se Kentera primjenjuje onako kako je propisana. (vidjeti dio 5.3)
English: Kentera should be used with caution in patients with hepatic or renal impairment.
Croatian: Kenteru je potrebno primjenjivati uz oprez u bolesnika s oštećenjem jetre ili bubrega.
English: Steady-state conditions are reached during the second application of the transdermal patch.
Croatian: Stanje dinamičke ravnoteže doseže se pri drugoj primjeni transdermalnog flastera.
English: Apply immediately upon removal from the protective sachet.
Croatian: Primijenite odmah nakon vađenja iz zaštitne vrećice.
English: Figure C:
Croatian: Slika C:
English: - Grab the loose edge at either corner and peel off the second piece of the liner.
Croatian: - Uhvatite slobodni rub za bilo koji ugao i uklonite i drugi dio zaštitnog sloja s ljepljive površine flastera.
English: slowness of movement, impaired balance, and a shuffling gait.
Croatian: usporenost kretnji, narušena ravnoteža i povlačenje nogu po podlozi pri hodu
English: Apply immediately after opening the sachet.
Croatian: Primijeniti odmah nakon otvaranja vrećice.
English: The use of Kentera in patients with hepatic impairment should be carefully monitored.
Croatian: Primjenu Kentere u bolesnika s oštećenjem jetre potrebno je pažljivo pratiti.
English: Mild redness may be present at the application site.
Croatian: Na mjestu primjene može biti prisutno blago crvenilo.
English: Urinary void volume (ml) Baseline
Croatian: Volumen izmokrene mokraće (ml) Početna vrijednost
English: The R-isomer of oxybutynin shows greater selectivity for the M1 and M3 muscarinic subtypes (predominant in bladder detrusor muscle and parotid gland) compared to the M2 subtype (predominant in cardiac tissue).
Croatian: M3 (predominantni u detruzoru mjehura i parotidnoj žlijezdi) u usporedbi s podvrstom M2 (predominantni u tkivu srca).
English: - The active substance is oxybutynin.
Croatian: - Djelatna tvar je oksibutinin.
English: Anticholinergic agents may potentially alter the absorption of some concomitantly administered medicinal products due to anticholinergic effects on gastrointestinal motility.
Croatian: Antikolinergička sredstva mogu promijeniti apsorpciju nekih istodobno primijenjenih lijekova zbog antikolinergičkog učinka na gastrointestinalni motilitet.
English: Kentera works by allowing the bladder to expand and accommodate more urine.
Croatian: Kentera djeluje tako što omogućuje širenje mokraćnog mjehura koji onda može prihvatiti veću količinu mokraće.
English: Figure B:
Croatian: Slika B:
English: The frequency of possible side effects listed below is defined using the following convention: - Very common (affects more than 1 user in 10) - Common (affects 1 to 10 users in 100) - Uncommon (affects 1 to 10 users in 1,000) - Rare (affects 1 to 10 users in 10,000) - Very rare (affects less than 1 user in 10,000) - Not known (frequency cannot be estimated from the available data).
Croatian: Učestalost mogućih nuspojava navedenih u nastavku definirana je na sljedeći način: - Vrlo često (javlja se kod više od 1 na 10 korisnika) - Često (javlja se kod 1 do 10 na 100 korisnika) - Manje često (javlja se kod 1 do 10 na 1000 korisnika)
English: Kentera 3.9 mg / 24 hours transdermal patch
Croatian: Kentera 3,9 mg / 24 sata transdermalni flaster
English: Do not use Kentera after the expiry date which is stated on the multidose container with metering pump and the carton after EXP.
Croatian: Kentera se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na višedoznom spremniku s odmjernom pumpicom i kutiji iza „Rok valjanosti“.
English: Diarrhoea, nausea, dyspepsia, vomiting, haemorrhoids
Croatian: Proljev, mučnina, dispepsija, povraćanje,
English: There are no adequate data on the use of oxybutynin topical gel in pregnant women.
Croatian: Ne postoje adekvatni podaci o primjeni oksibutinin gela za topikalnu primjenu kod trudnica.
English: Each transdermal patch releases 3.9 mg of oxybutynin per 24 hours.
Croatian: Jedan transdermalni flaster oslobađa 3,9 mg oksibutinina tijekom 24 sata.
English: This should be borne in mind when administering azole antifungals (e.g. ketoconazole) or macrolide antibiotics (e.g. erythromycin) concurrently with oxybutynin.
Croatian: O tome bi trebalo bi voditi računa prilikom istodobne primjene azolskih antimikotika (npr. ketokonazola) ili makrolidnih antibiotika (npr. eritromicina) uz oksibutinin.
English: The sachet is constructed from a multi-layer foil based laminated pouch material.
Croatian: Vrećica je izrađena od laminiranog materijala za vrećice koji se sastoji od višeslojne folije
English: - If you are unable to have complete bowel movements.
Croatian: Ako ne možete potpuno isprazniti crijeva.
English: Baths, showers, swimming and exercise should not affect the patch as long as you don't rub the patch as you wash. Avoid soaking in a hot bath for a long period of time, which can make the patch come off.
Croatian: Kupanje, tuširanje, plivanje i vježbanje ne bi smjelo utjecati na flaster ako ga ne trljate dok se perete.
English: Urticaria, hot flushes
Croatian: Urtikarija, navale vrućine
English: Emotional health subscale
Croatian: Općenita percepcija zdravlja
English: Acrylic copolymer adhesive solution containing 2-ethylhexyl acrylate N-vinyl pyrrolidone and hexamethyleneglycol dimethacrylate polymer domains
Croatian: Srednji sloj triacetin adhezivna otopina akrilnog kopolimera koja sadrži 2-etilheksil akrilat N-vinil pirolidon i heksametilenglikol dimetakrilat polimer
English: See Figure B.
Croatian: Pogledajte sliku B.
English: The active substance is oxybutynin.
Croatian: Djelatna tvar je oksibutinin.
English: Urinary retention: Anticholinergic products should be administered with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention.
Croatian: Urinarna retencija: Antikolinergičke lijekove potrebno je primjenjivati uz oprez u bolesnika s klinički značajnom opstrukcijom mokraćnog mjehura zbog rizika od urinarne retencije.
English: Overdosage with oxybutynin has been associated with anticholinergic effects including CNS excitation, flushing, fever, dehydration, cardiac arrhythmia, vomiting, and urinary retention.
Croatian: Predoziranje oksibutininom povezano je s antikolinergičkim učincima, uključujući ekscitaciju SŽS-a, navale crvenila, vrućicu, dehidraciju, srčanu aritmiju, povraćanje i urinarnu retenciju.
English: Tear the sachet open at the indentation just before use.
Croatian: 1. korak: Otvorite vrećicu tako da je poderete na urezu neposredno prije primjene.
English: Excipients: triacetin; acrylic adhesive (containing 2-ethylhexyl acrylate; N-vinyl pyrrolidone and hexamethyleneglycol dimethacrylate polymer domains).
Croatian: POPIS POMOĆNIH TVARI Pomoćne tvari: triacetin; akrilni adheziv (sadrži 2-etilheksil akrilat, N-vinil pirolidon i heksametilenglikol dimetakrilat polimer).
English: Anticholinergic medicinal products should be administered with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention.
Croatian: Antikolinergičke lijekove potrebno je primjenjivati uz oprez u bolesnika s klinički značajnom opstrukcijom mokraćnog mjehura zbog rizika od urinarne retencije.
English: (N=400) Mean (SD) Median Mean (SD) Median
Croatian: Medijan Srednja vrijednost (SD)
English: Figure D:
Croatian: Slika D:
English: - dry skin - itchy rash - painful or difficulty urinating - blood in urine - kidney pain - delayed or slow start of urinary flow - tiredness, exhaustion - swelling of ankles, feet or fingers - small bumps at application site - numbness at application site - redness at application site - irritation at application site - pain at application site - pus filled bumps at application site - abnormal electrocardiogram (ECG or EKG,test of heart) - change in ECG or EKG - high chloride levels in blood
Croatian: - umor, iscrpljenost - oticanje gležnjeva, stopala ili prstiju - kvržice na mjestu primjene - utrnulost na mjestu primjene - crvenilo na mjestu primjene - nadraženost na mjestu primjene - bol na mjestu primjene - gnojne kvržice na mjestu primjene - abnormalni elektrokardiogram (EKG, ispitivanje srca) - promjena u EKG-u - visoke razine klorida u krvi.
English: Empty multidose container must be discarded in accordance with local requirements.
Croatian: Prazan višedozni spremnik valja zbrinuti sukladno lokalnim propisima.
English: Environmental Risk Assessment The active substance oxybutynin is persistent in the environment.
Croatian: Djelatna tvar oksibutinin je perzistentna u okolišu.
English: Do not use Kentera after the date shown on the sachet and the carton.
Croatian: Kentera se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na vrećici i kutiji.
English: Dysuria, haematuria, renal pain, urinary retention
Croatian: Dizurija, hematurija, bol u bubrezima, urinarna retencija
English: Read all of this leaflet carefully before you start using Kentera.
Croatian: Pažljivo pročitajte cijelu uputu prije nego počnete primjenjivati Kenteru.
English: Read all of this leaflet carefully before you start using Kentera
Croatian: Pažljivo pročitajte cijelu uputu prije nego počnete primjenjivati Kenteru
English: Anticholinergic medicinal products may decrease gastrointestinal motility and should be used with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention, and in conditions such as ulcerative colitis, and intestinal atony.
Croatian: Gastrointestinalni poremećaji Antikolinergički lijekovi mogu usporiti gastrointestinalni motilitet i potrebno ih je primjenjivati uz oprez u bolesnika s gastrointestinalnim opstruktivnim poremećajima zbog rizika od želučane retencije te u slučajevima ulceroznog kolitisa i crijevne atonije.
English: Use of oxybutynin while breast-feeding is therefore not recommended.
Croatian: Stoga primjena oksibutinina tijekom dojenja nije preporučljiva.
English: - Free of cuts, rashes or any other skin irritation.
Croatian: - bez pudera, losiona i ulja za tijelo. - bez posjekotina, osipa ili ostalih iritacija (nadraženosti) kože.
English: Application site erythema, application site reaction, application site rash
Croatian: Eritem na mjestu primjene, reakcija na mjestu primjene, osip na mjestu primjene
English: HOW TO STORE KENTERA
Croatian: KAKO PRIMJENJIVATI KENTERU
English: Adverse reactions considered associated with anticholinergic therapy in general or observed with oral administration of oxybutynin, but as of yet not with Kentera in clinical trials or post-marketing, are:
Croatian: Nuspojave koje se smatraju općenito povezane s antikolinergičkom terapijom ili su opažene uz peroralnu primjenu oksibutinina, ali još nisu primijećene uz Kenteru u kliničkim ispitivanjima ili nakon stavljanja lijeka u promet, jesu anoreksija, povraćanje, refluksni ezofagitis, smanjeno znojenje,
English: Kentera 3.9 mg / 24 hours transdermal patch oxybutynin
Croatian: Kentera 3,9 mg / 24 sata transdermalni flaster oksibutinin
English: Application site pruritis, application site dermatitis
Croatian: Svrbež na mjestu primjene, dermatitis na mjestu primjene
English: Do not expose the patch to the sun. Place the patch underneath your clothing.
Croatian: Flaster neka bude ispod odjeće.
English: Applying Kentera while taking other medicines that have similar side effects, such as dry mouth, constipation, and drowsiness, may increase how often and how severe these side effects are experienced.
Croatian: Primjena Kentere uz primjenu drugih lijekova koji imaju slične nuspojave, poput suhih usta, zatvora i omamljenosti, može povećati učestalost i težinu navedenih nuspojava.
English: Kentera 90.7 mg/g gel oxybutynin
Croatian: Kentera 90,7 mg/g gel oksibutinin
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS SACHET LABELLING
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE
English: Applying the Kentera patch at the same time as taking other medicines that have similar side effects such as dry mouth, constipation and drowsiness, may increase how often and how severe these side effects are experienced.
Croatian: Primjena flastera Kentera uz istodobnu primjenu drugih lijekova koji imaju slične nuspojave, poput suhih usta, zatvora i omamljenosti, može povećati učestalost i težinu navedenih nuspojava.
English: Recordati Ireland Ltd. Tel: +353 (0) 21 4379400
Croatian: Tel: +353 (0) 21 4379400
English: As oxybutynin is metabolised by the cytochrome P 450 isoenzyme CYP 3A4, interactions with medicinal products that inhibit this isoenzyme, or known inducers of CYP 3A4, cannot be ruled out.
Croatian: 3A4 citokroma P450, ne može se isključiti interakcija s lijekovima koji inhibiraju taj izoenzim ili s poznatim induktorima CYP 3A4.
English: Common side effects - headache - dizziness - dry mouth - constipation - itchiness - itchiness, inflammation, or pain at the application site
Croatian: - glavobolja - omaglica - suha usta - zatvor - svrbež - svrbež, upala, ili bol na mjestu primjene.
English: The backing film is to be removed prior to patch application.
Croatian: Zaštitni sloj treba ukloniti prije primjene flastera.
English: BEFORE YOU USE KENTERA Do not use Kentera:
Croatian: Nemojte primjenjivati Kenteru:
English: Uncommon side effects: - upper respiratory tract or fungal infections - anxiety
Croatian: - infekcija gornjih dišnih puteva ili gljivične infekcije - tjeskoba - smetenost - nervoza - uznemirenost
English: swimming, showering, exercising or immersing the application site in water for one hour after application.
Croatian: vježbati ili uranjati mjesto primjene u vodu jedan sat nakon primjene.
English: The sachet is constructed from a multi-layer foil based laminate pouch material (polymethacrylate/acrylonitrile copolymer/adhesive/aluminum/low density polyethylene/paper).
Croatian: (polimetakrilat/kopolimer akrilonitrila/adheziv/aluminij/polietilen niske gustoće/papir).
English: Mean (SD) change from baseline in KHQ Domain Scores at Week 12 (LOCF)
Croatian: Srednja vrijednost (SD) promjena od početne vrijednosti u rezultatima područja KHQ