FrancophonIA/ELRC3.0 huggingface dataset:
English: In the short-term trials, the primary efficacy endpoint was defined as the mean change from baseline to Week 6 in Positive and Negative Syndrome Scale (PANSS) total scores, a validated multi-item inventory composed of five factors to evaluate positive symptoms, negative symptoms, disorganised thoughts, uncontrolled hostility/excitement, and anxiety/depression.
Croatian: U kratkotrajnim ispitivanjima, primarna mjera ishoda djelotvornosti bila je definirana kao srednja promjena od početne vrijednosti do Tjedna 6 u ukupnom zbroju prema ljestvici pozitivnih i negativnih simptoma (PANSS), validiranoj višedjelnoj ljestvici sastavljenoj od pet čimbenika za procjenu pozitivnih simptoma, negativnih simptoma, dezorganiziranih misli, nekontrolirane agresije/uzbuđenosti i anksioznosti/depresije.
English: Major findings in repeat-dose toxicity studies of lurasidone were centrally-mediated endocrine changes resulting from serum prolactin elevations in rats, dogs and monkeys.
Croatian: Glavno otkriće ispitivanja toksičnosti ponovljenih doza lurasidona bile su centralno posredovane endokrine promjene što je rezultiralo povišenjem serumskog prolaktina u štakora, pasa i majmuna.
English: The recommended starting dose is 37 mg of lurasidone once daily.
Croatian: Preporučena početna doza je 37 mg lurasidona jednom dnevno.
English: • diltiazem (to treat high blood pressure)
Croatian: • diltiazem (za liječenje visokog krvnog tlaka)
English: Cases of venous thromboembolism (VTE) have been reported with antipsychotic medicinal products.
Croatian: Slučajevi venske tromboembolije (VTE) zabilježeni su s antipsihoticima.
English: The concomitant administration of lurasidone and grapefruit juice has not been assessed.
Croatian: Istovremena primjena lurasidona i soka od grejpa nije ispitana.
English: In a meta-analysis of 17 controlled clinical trials, elderly patients with dementia treated with other atypical antipsychotics, including risperidone, aripiprazole, olanzapine, and quetiapine had an increased risk of mortality compared to placebo.
Croatian: U meta-analizi 17 kontroliranih kliničkih ispitivanja, stariji bolesnici s demencijom liječeni s drugim atipičnim antipsihoticima, uključujući risperidon, aripiprazol, olanzapin i kvetiapin, imali su povećani rizik smrtnosti u usporedbi s placebom.
English: Lurasidone and its metabolites ID-14283, ID-14326, ID-20219 and ID-20220 correspond to approximately 11.4, 4.1, 0.4, 24 and 11% respectively, of serum radioactivity respectively.
Croatian: Lurasidon i njegovi metaboliti ID-14283, ID-14326, ID-20219 i ID-20220 odgovaraju za približno 11,4; 4,1; 0,4; 24 odnosno 11% serumske radioaktivnosti.
English: 37 mg 74 mg 111 mg 148 mg
Croatian: 111 mg 148 mg
English: • Fever, sweating, muscle stiffness, and reduced consciousness.
Croatian: • vrućica, znojenje, ukočenost mišića, smanjena svijest.
English: In case of severe extrapyramidal symptoms, anticholinergic medicinal products should be administered.
Croatian: U slučaju teških ekstrapiramidnih simptoma, treba primijeniti antikolinergike.
English: The mechanism of action of the minor active metabolite of lurasidone ID-14283 is similar to that of lurasidone.
Croatian: Mehanizam djelovanja manje aktivnog metabolita lurasidona ID-14283 sličan je onom lurasidona.
English: These effects were due to the hyperprolactinemia following lurasidone treatment, affecting the oestrous cycle and copulatory behaviour as well as the maintenance of corpus luteum of the female rats, resulting in a decrease in implantation and the number of live foetuses.
Croatian: Ovo djelovanje bilo je povezano s hiperprolaktinemijom nakon liječenja lurasidonom, djelujući na ciklus estrusa i kopulacijsko ponašanje kao i na održavanje corpus luteuma ženki štakora, uzrokujući smanjenje implantacija i broj živih fetusa.
English: No data are available in elderly people treated with 148 mg of lurasidone.
Croatian: Nema podataka o liječenju starijih osoba lurasidonom od 148 mg.
English: ΠΑΡΑΓΩΓΗΣ & ΕΜΠΟΡΙΑΣ ΦΑΡΜΑΚΩΝ Aχαίας 4 & Τροιζηνίας GR-14564 Νέα Κηφισιά Τηλ: + 30 210 626 9200
Croatian: ANGELINI PHARMA HELLAS ABEE ΠΑΡΑΓΩΓΗΣ & ΕΜΠΟΡΙΑΣ ΦΑΡΜΑΚΩΝ Aχαίας 4 & Τροιζηνίας GR-14564 Νέα Κηφισιά Τηλ: + 30 210 626 9200 info@angelinipharma.gr
English: Events of interest to the class Extrapyramidal symptoms (EPS): In the short-term placebo controlled studies, the incidence of reported events related to EPS, excluding akathisia and restlessness, was 13.5% for lurasidone-treated subjects versus 5.8% for placebo-treated subjects.
Croatian: Ekstrapiramidni simptomi (EPS): U kratkotrajnim placebo kontroliranim ispitivanjima, incidencija prijavljenih događaja povezanih s EPS, ne ubrajajući akatiziju i nemir, bila je 13,5% u ispitanika liječenih lurasidonom, naspram 5,8% onih liječenih placebom.
English: Latuda 37 mg
Croatian: 37 mg
English: Physicians should therefore weigh the risks versus the benefits when prescribing Lurasidone to patients with Parkinson's disease.
Croatian: Liječnici stoga trebaju procijeniti odnos rizika naspram koristi kada lurasidon propisuju bolesnicima s Parkinsonovom bolešću.
English: There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, or feeding disorder.
Croatian: Zabilježeni su agitacija, hipertonija, hipotonija, tremor, pospanost, poremećaji disanja ili poremećaj hranjenja.
English: CDRS-R Total Score
Croatian: Primarna mjera ishoda: CDRS-R ukupni rezultat
English: The maximum daily dose in moderate hepatic impairment patients should not exceed 74 mg and in severe hepatic impairment patients should not exceed 37 mg once daily.
Croatian: Najviša dnevna doza u bolesnika s umjerenim oštećenjem jetre ne smije prekoračiti 74 mg dnevno, a u bolesnika s teškim oštećenjem jetre ne smije prekoračiti 37 mg jednom dnevno.
English: In a long-term safety study clinically stable patients were treated using 37 - 111 mg lurasidone or risperidone 2 - 6 mg.
Croatian: U dugotrajnom ispitivanju sigurnosti klinički stabilni bolesnici liječeni su lurasidonom 37-111 mg ili risperidonom 2-6 mg.
English: The probability of all-cause discontinuation at Week 28 were 58.2% for lurasidone and 69.9% for placebo (p=0.072).
Croatian: Vjerojatnost prekida terapije zbog bilo kojeg razloga u 28. tjednu bila je 58,2% za lurasidon i 69,9% za placebo (p=0,072).
English: Lurasidone had a small increase from baseline to Month 12 in body weight and body mass index (Mean (SD): 0.73 (3.36) kg and 0.28 (1.17) kg/m2, respectively) compared to quetiapine extended release (1.23 (4.56) kg and 0.45 (1.63) kg/m2, respectively).
Croatian: Lurasidon je imao u Mjesecu 12, u odnosu na početnu vrijednost, mali porast tjelesne težine i indeksa tjelesne mase (srednja vrijednost (SD): 0,73 (3,36) kg, odnosno 0,28 (1,17) kg/m2) u usporedbi s kvetiapinom s produljenim oslobađanjem (1,23 (4,56) kg, odnosno 0,45 (1,63) kg/m2).
English: Neonates exposed to antipsychotics (including lurasidone) during the third trimester are at risk of adverse reactions including extrapyramidal and/or withdrawal symptoms that may vary in severity and duration following delivery.
Croatian: Novorođenčad izložena antipsihoticima (uključujući lurasidon) tijekom trećeg trimestra trudnoće ima rizik nuspojava uključujući ekstrapiramidne i/ili simptome apstinencije koji mogu varirati u težini i trajanju nakon poroda.
English: A persistent effect of posaconazole on lurasidone exposure was observed up to 2-3 weeks after stop of posaconazole co-administration.
Croatian: Postojani učinak posakonazola na izloženost lurasidonu opažen je do 2 - 3 tjedna nakon prekida istodobne primjene posakonazola.
English: If you forget to take Latuda
Croatian: Ako ste zaboravili uzeti lijek Latuda
English: Angelini Farmacéutica S.A. C. Osi, 7
Croatian: Spain/ España Angelini Farmacéutica S.A. C. Osi, 7
English: Venous thromboembolism: Cases of venous thromboembolism, including cases of pulmonary embolism and cases of deep vein thrombosis have been reported with antipsychotic drugs -Frequency unknown.
Croatian: Venska tromboembolija: Slučajevi venske tromboembolije, uključujući slučajeve plućne embolije i slučajeve duboke venske tromboze prijavljeni su s antipsihoticima.
English: A single dose of 10 mg/kg lurasidone hydrochloride to pregnant rats resulted in fetal exposure.
Croatian: Jednokratna doza od 10 mg/kg lurasidonklorida u skotnih štakora uzrokovala je fetalnu izloženost.
English: Coadministration of lurasidone with digoxin (a P-gp substrate) did not increase the exposure to digoxin and only slightly increased Cmax (1.3 -fold) and therefore, it is considered that lurasidone can be coadministered with digoxin.
Croatian: Istovremena primjena lurasidona s digoksinom (P-gp supstratom) nije povećavala izloženost digoksinu i tek je blago povećavala Cmax (1,3 puta) pa se zbog toga smatra da se lurasidon može davati istovremeno s digoksinom.
English: • enlarged breasts in male (gynecomastia), milky nipple discharge (galactorrhea), absence of menstruation (amenorrhea) or erectile dysfunction
Croatian: • uvećane dojke kod muškaraca (ginekomastija), mliječni iscjedak iz bradavica (galaktoreja), izostanak menstruacije (amenoreja) ili erektilna disfunkcija
English: Appropriate clinical monitoring is advisable in diabetic patients and in patients with risk factors for the development of diabetes mellitus.
Croatian: Preporučuje se odgovarajuće kliničko praćenje u bolesnika s dijabetesom kao i u bolesnika s faktorima rizika za razvoj diabetes mellitusa.
English: • increased blood prolactin, increased blood glucose (blood sugar), increase in some liver enzymes, seen in blood tests
Croatian: • povišen prolaktin u krvi, povišena glukoza (šećer) u krvi, povišeni neki jetreni enzimi, što se vidi iz krvnih pretraga
English: Switching between antipsychotic medicinal products Due to different pharmacodynamic and pharmacokinetic profiles among antipsychotic medicinal products, supervision by a clinician is needed when switching to another antipsychotic product is considered medically appropriate.
Croatian: Zbog razlika u farmakodinamičkim i farmakokinetičkim profilima među lijekovima s antipsihotičkim učinkom, potreban je nadzor kliničara kad se prijelaz na drugi antipsihotički lijek smatra se medicinski prikladnim.
English: If you stop taking Latuda
Croatian: Ako prestanete uzimati lijek Latuda
English: • ever been diagnosed with a condition whose symptoms include high temperature and muscle stiffness (also known as neuroleptic malignant syndrome) or if you have ever experienced rigidity, tremors or problems moving (extrapyramidal symptoms) or abnormal movements of the tongue or face (tardive dyskinesia).
Croatian: • ako Vam je ikada dijagnosticirano stanje sa simptomima koji uključuju povišenu temperaturu i ukočenost mišića (također poznato kao neuroleptički maligni sindrom) ili ako su se ikad javili rigidnost, tremor, ili poteškoće u pokretima (ekstrapiramidni sindrom) ili nenormalni pokreti jezika ili lica (tardivna diskinezija).
English: For administration of medicinal products that are substrates of CYP3A4 with a narrow therapeutic range, see section 4.5.
Croatian: Za primjenu lijekova koji su supstrati za CYP3A4 s uskom terapijskom širinom, vidjeti dio 4.5.
English: Ancona (AN), Italy Millmount Healthcare Ltd.
Croatian: Millmount Healthcare Ltd.
English: Medicinal products with dopamine receptor antagonistic properties have been associated with the induction of tardive dyskinesia characterised by rhythmical involuntary movements, predominantly of the tongue and/or face.
Croatian: Lijekovi s osobinama antagonista dopaminskih receptora povezani su s indukcijom tardivne diskinezije koju karakteriziraju ritmički nevoljni pokreti, naročito jezika i/ili lica.
English: • verapamil (to treat high blood pressure or chest pain).
Croatian: • verapamil (za liječenje visokog krvnog tlaka ili boli u prsnom košu).
English: Sleepiness, dizziness and vision problems may occur during treatment with this medicine (see section 4, Possible side effects).
Croatian: Tijekom liječenja ovim lijekom mogu se javiti pospanost, omaglica i poteškoće s vidom (pogledajte dio 4, Moguće nuspojave).
English: Hyperhidrosis Angioedema Stevens-Johnson syndrome
Croatian: Poremećaji kože i potkožnog tkiva osip pruritus hiperhidroza angioedem Stevens-Johnsonov sindrom
English: Lurasidone works by blocking receptors in the brain to which the substances dopamine and serotonin attach.
Croatian: Lurasidon djeluje blokirajući receptore u mozgu na koje se vežu tvari dopamin i serotonin.
English: In a food effect study, lurasidone mean Cmax and AUC increased approximately by 2-3-times and 1.5-2-times, respectively, when administered with food compared to the levels observed under fasting conditions.
Croatian: U ispitivanju djelovanja hrane, srednje vrijednosti Cmax i AUC lurasidona povećavaju se 2-3 puta, odnosno 1,5-2 puta, ukoliko se primjenjuje s hranom, u usporedbi s razinama zabilježenim kada se primjenjuje natašte.
English: Post marketing reports of clinically serious cases of skin and other hypersensitivity reactions have been reported in association with lurasidone treatment, including some reports of Stevens-Johnson syndrome.
Croatian: Nakon stavljanja lijeka u promet zabilježeni su klinički ozbiljni slučajevi kožnih i drugih reakcija preosjetljivosti povezanih s liječenjem lurasidonom, uključujući i slučajeve Stevens-Johnsonovog sindroma.
English: • bosentan (to treat high blood pressure or ulcers of the fingers)
Croatian: • bosentan (za liječenje visokog krvnog tlaka ili ranica na prstima)
English: In the main clinical efficacy studies, lurasidone was administered at doses of 37-148 mg lurasidone.
Croatian: U glavnim kliničkim ispitivanjima djelotvornosti, lurasidon je primjenjivan u dozama od 37-148 mg lurasidona
English: • Parkinsonism: This is a medical term that describes many symptoms which include increase in saliva secretion or watery mouth, drooling, jerks when bending the limbs, slow, reduced or impaired body movements, no expression in the face, muscle tightness, stiff neck, muscle stiffness, small, shuffling, hurried steps and lack of normal arm movements when walking, persistent blinking in response to tapping of the forehead (an abnormal reflex)
Croatian: • Parkinsonizam: To je medicinski izraz koji opisuje mnoge simptome koji uključuju pojačano lučenje sline ili mokra usta, slinjenje, iznenadno trzanje kod svijanja udova, spori, smanjeni ili oslabljeni pokreti tijela, bezizražajno lice, napetost mišića, ukočen vrat, ukočenost mišića, mali, promjenjivi, ubrzani koraci te nedostatak normalnih pokreta ruku tijekom hoda, ustrajno treptanje kao odgovor na lupkanje na čelo (abnormalni refleks)
English: The safety of lurasidone has been evaluated at doses of 18.5 -148 mg in clinical studies in patients with schizophrenia treated for up to 52 weeks and in the post-marketing setting.
Croatian: Sigurnost lurasidona procjenjivana je s dozama od 18,5-148 mg u kliničkim ispitivanjima u bolesnika sa shizofrenijom liječenih do 52 tjedna i nakon stavljanja lijeka u promet.
English: Lurasidone doses, which varied across the five trials, ranged from 37 to 148 mg lurasidone once daily.
Croatian: Doze lurasidona, koje su varirale unutar pet ispitivanja, bile su u rasponu od 37 do 148 mg lurasidona jednom dnevno.
English: The efficacy of lurasidone in the treatment of schizophrenia was demonstrated in five multi-centre, placebo-controlled, double-blind, 6-week trials in subjects who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for schizophrenia.
Croatian: Djelotvornost lurasidona u liječenju shizofrenije dokazana je u pet multicentričnih, placebo kontroliranih, dvostruko slijepih, 6-tjednih ispitivanja u ispitanika koji su zadovoljili kriterije za shizofreniju iz Dijagnostičkog i statističkog priručnika mentalnih poremećaja, četvrto izdanje (DSM-IV).
English: • abnormal breast enlargement, breast pain, milk secretion from breasts
Croatian: • nenormalno povećanje dojki, bol u dojkama, lučenje mlijeka iz dojki
English: Lurasidone is an inhibitor of P-gp, BCRP and OCT1 in vitro (see section 4.5).
Croatian: Lurasidon je in vitro inhibitor P-gp, BRCP i OCT1 (vidjeti dio 4.5).
English: Breast feeding in women receiving lurasidone should be considered only if the potential benefit of treatment justifies the potential risk to the child.
Croatian: Kod žena koje uzimaju lurasidon, dojenje se preporučuje samo ako potencijalna korist liječenja nadmašuje potencijalni rizik za dijete.
English: Lurasidone was not teratogenic in rats or rabbits at an exposure similar to or below the maximum recommended human dose (148 mg lurasidone).
Croatian: Lurasidon nije bio teratogen u štakora ili kunića prilikom izloženosti dozi sličnoj ili onoj ispod maksimalne preporučene doze za ljude (148 mg lurasidona).
English: The incidence of akathisia for lurasidone-treated subjects was 12.9% versus 3.0% for placebo-treated subjects.
Croatian: Incidencija akatizije u ispitanika liječenih lurasidonom bila je 12,9%, prema 3,0% u ispitanika na placebu.
English: Grapefruit juice inhibits CYP3A4 and may increase the serum concentration of lurasidone.
Croatian: Sok od grejpa inhibira CYP3A4 i može povećati serumsku koncentraciju lurasidona.
English: When lurasidone is coadministered with mild or moderate CYP3A4 inducers, the efficacy of lurasidone needs to be carefully monitored and a dose adjustment may be needed.
Croatian: Kad se lurasidon primjenjuje s blagim ili umjerenim CYP3A4 induktorima, potrebno je pomno nadzirati djelotvornost lurasidona i može biti potrebno prilagoditi dozu.
English: For strong CYP3A4 inhibitors and inducers see section 4.3.
Croatian: Za jake inhibitore i induktore CYP3A4 vidjeti dio 4.3.
English: for placebo.
Croatian: Placebo
English: Gastric lavage (after intubation if patient is unconscious) and administration of activated charcoal together with a laxative should be considered.
Croatian: Preporučuje se ispiranje želuca (nakon intubacije ukoliko je bolesnik bez svijesti) i primjena aktivnog ugljena zajedno s laksativom.
English: • shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding.
Croatian: • drhtanje, ukočenost i/ili slabost u mišićima, pospanost, agitacija, poteškoće s disanjem i poteškoće s hranjenjem.
English: It is not known if lurasidone passes into breast milk.
Croatian: Nije poznato prelazi li lurasidon u majčino mlijeko.
English: Schizophrenia is a disorder with symptoms such as hearing things, seeing or sensing things that are not there, mistaken beliefs, unusual suspiciousness, becoming withdrawn, incoherent speech and behaviour and emotional flatness.
Croatian: Shizofrenija je poremećaj sa simptomima poput slušnih halucinacija, vidnih ili osjetilnih halucinacija, zabluda, neuobičajene sumnjičavosti, povlačenja u sebe, neorganiziranog govora i ponašanja te nemogućnosti izražavanja emocija.
English: P-values for olanzapine and quetiapine XR vs. placebo were unadjusted.
Croatian: P-vrijednosti za olanzapin i kvetiapin XR naspram placebo nisu bile prilagođene.
English: (b) Lurasidone doses of 18.5, 37, 55.5, 74 mg are equivalent to 20, 40, 60 and 80 amounts of lurasidone hydrochloride.
Croatian: (b) Doze lurasidona od 18,5; 37; 55,5; 74 mg jednake su količinama lurasidon hidroklorida od 20, 40, 60 i 80.
English: LS Mean Change (SE)
Croatian: LS srednja vrijednost promjene (SE)
English: Coadministration of lurasidone with P-gp and BCRP inhibitors may increase exposure to lurasidone.
Croatian: Istovremena primjena lurasidona s P-gp i BCRP inhibitorima može povećati izloženost lurasidonu.
English: Latuda 74 mg
Croatian: 74 mg
English: If you take more of this medicine than you should, contact your doctor immediately.
Croatian: Ako uzmete više lijeka Latuda nego što ste trebali Odmah se obratite svom liječniku ako ste uzeli više ovog lijeka nego što ste trebali.
English: Moderate CYP3A4 inhibitors are estimated to result in a 2-5-fold increase in exposure of CYP3A4 substrates.
Croatian: Procjenjuje se da umjereni CYP3A4 inhibitori rezultiraju s 2-5 puta povećanom izloženošću CYP3A4 supstrata.
English: The maximum dose should not exceed 148 mg once a day.
Croatian: Ne smije se prekoračiti maksimalna dnevna doza od 148 mg jednom dnevno.
English: • if you have kidney or liver problems.
Croatian: • imate li probleme s bubrezima ili jetrom.
English: • Rhabdomyolysis which is the breakdown of muscle fibres that leads to the release of muscle fibre contents (myoglobin) into the bloodstream, seen as muscle pain, being sick, being confused, an abnormal heart rate and rhythm, and possibly dark urine
Croatian: • Rabdomioliza što je propadanje mišićnih vlakana što dovodi do otpuštanja sadržaja mišićnih vlakana (mioglobina) u krvotok, što se očituje kao bol u mišićima, povraćanje, zbunjenost, nenormalna brzina otkucaja i ritam srca, a moguće i tamna mokraća
English: Lurasidone has not been studied in elderly patients with dementia.
Croatian: Lurasidon nije ispitivan na starijim bolesnicima s demencijom.
English: • medicines containing ergot alkaloid derivatives (used for treating migraines), and other medicines including terfenadine and astemizole (used for treating hay fever and other allergic conditions), cisapride (used for treating digestive problems), pimozide (used to treating psychiatric illnesses), quinidine (used for treating heart conditions), bepridil (used for treating chest pain).
Croatian: • lijekove koji sadrže derivat ergot alkaloida (rabi se za liječenje migrene), te druge lijekove uključujući terfenadin i astemizol (rabe se za liječenje peludne groznice i drugih alergijskih stanja), cisaprid (rabi se za liječenje probavnih problema), pimozid (rabi se za neka psihijatrijska oboljenja), kinidin (rabi se za liječenje srčanih stanja), bepridil (rabi se za liječenje boli u prsnom košu).
English: Tell your doctor if you take any of these medicines since your doctor may change your dose of Latuda.
Croatian: Obavijestite svog liječnika ako uzimate bilo koji od ovih lijekova, jer će on možda izmijeniti dozu lijeka Latuda.
English: Additional signs may include myoglobinuria (rhabdomyolysis) and acute renal failure.
Croatian: Dodatni simptomi mogu uključivati mioglobinuriju (rabdomiolizu) i akutno zatajenje bubrega.
English: A clinical drug interaction study investigating the effect of coadministration of lurasidone on patients taking oral combination contraceptives including norgestimate and ethinyl estradiol, indicated that lurasidone had no clinically or statistically meaningful effects on the pharmacokinetics of the contraceptive or sex hormone binding globulin (SHBG) levels.
Croatian: Kliničko ispitivanje interakcija lijeka istraživalo je učinak lurasidona kod bolesnika koji su uzimali oralne kombinirane kontraceptive uključujući norgestimat i etinilestradiol, indicirajući da lurasidon nije imao klinički ni statistički značajne učinke na farmakokinetiku kontraceptiva ili razinu globulina na kojeg se vežu spolni hormoni (SHBG: sex hormone binding globulin).
English: Kaplan-Meier estimates of the probability of relapse at Week 28 were 42.2% for lurasidone and 51.2% for placebo.
Croatian: Kaplan-Meierova procjena vjerojatnosti relapsa u 28. tjednu bila je 42,2% za lurasidon i 51,2% za placebo.
English: Long-term maintenance efficacy of lurasidone (37 to 148 mg lurasidone once daily ) was demonstrated in a 12 month non-inferiority trial with quetiapine extended release (200 to 800 mg once daily).
Croatian: Djelotvornost lurasidona kod dugotrajne terapije održavanja (37 do 148 mg lurasidona jednom dnevno) pokazana je u 12 mjesečnom ispitivanju neinferiornosti s kvetiapinom s produljenim oslobađanjem (200 do 800 mg jednom dnevno).
English: If antiarrhythmic therapy is administered, disopyramide, procainamide, and quinidine carry a theoretical hazard of QT-prolonging effects when administered in patients with an acute overdose of lurasidone.
Croatian: Ako se primjenjuje antiaritmijska terapija, dizopiramid, prokainamid i kinidin nose teoretski rizik produženja QT intervala ukoliko se primjene u bolesnika koji su akutno predozirani lurasidonom.
English: Lurasidone was non-inferior to quetiapine extended release in time to relapse of schizophrenia.
Croatian: Lurasidon nije bio inferioran kvetiapinu s produljenim oslobađanjem u vremenu relapsa shizofrenije.