FrancophonIA/ELRC3.0 huggingface dataset:
English: Interference with determination of ionised calcium levels The measurement of ionised calcium levels might show falsely decreased values under treatment with leflunomide and/or teriflunomide (the active metabolite of leflunomide) depending on the type of ionised calcium analyser used (e.g. blood gas analyser).
Croatian: Interferencija pri utvrđivanju razina ioniziranog kalcija Mjerenje razina ioniziranog kalcija može pokazati lažno smanjene vrijednosti kod liječenja leflunomidom i/ili teriflunomidom (aktivnim metabolitom leflunomida) ovisno o vrsti korištenog analizatora ioniziranog kalcija (npr. analizator plina u krvi).
English: Absorption Excretion data from the
Croatian: Apsorpcija Prema podacima iz istraživanja s
English: • rosuvastatin, simvastatin, atorvastatin, pravastatin for hypercholesterolemia (high cholesterol)
Croatian: • rosuvastatin, simvastatin, atorvastatin, pravastatin za liječenje hiperkolesterolemije (povišeni kolesterol)
English: C-leflunomide in three healthy volunteers, no unchanged leflunomide was detected in plasma, urine or faeces.
Croatian: C-leflunomida u tri zdrava dobrovoljca nije otkriven nepromijenjeni leflunomid u plazmi, mokraći ili stolici.
English: Study MN303 was an optional 6-month blinded continuation of MN301 without the placebo arm, resulting in a 12-month comparison of leflunomide and sulphasalazine.
Croatian: Studija MN303 bila je neobavezni slijepi 6-mjesečni nastavak studije MN301 bez placeba, što je rezultiralo 12-mjesečnom usporedbom leflunomida i sulfasalazina.
English: Blood pressure Blood pressure must be checked before the start of leflunomide treatment and periodically thereafter.
Croatian: Krvni tlak Krvni tlak mora se izmjeriti prije početka liječenja leflunomidom te periodički nakon toga.
English: Tell your doctor if you plan to become pregnant after stopping treatment with Leflunomide medac, as you need to ensure that all traces of Leflunomide medac have left your body before trying to become pregnant.
Croatian: Obavijestite svog liječnika ako planirate zatrudnjeti nakon prekida terapije lijekom Leflunomid medac, jer je potrebno osigurati da se svi tragovi lijeka Lenflunomide medac uklone iz organizma prije nego što pokušate zatrudnjeti.
English: Women of childbearing potential must not take Leflunomide medac without using reliable contraceptive measures.
Croatian: Žene u reproduktivnoj dobi ne smiju uzimati Leflunomid medac bez upotrebe pouzdanih metoda kontracepcije.
English: Alanine aminotransferase (ALT) (or serum glutamopyruvate transferase SGPT) and a complete blood cell count, including a differential white blood cell count and a platelet count, must be checked simultaneously and with the same frequency:
Croatian: Alanin aminotransferazu (ALT) ili serumsku glutamopiruvat transferazu (SGPT) i kompletnu krvnu sliku, uključujući diferencijalnu bijelu krvnu sliku i broj trombocita, mora se provjeravati istodobno i u jednakim intervalima:
English: The risk of their occurrence can be increased in patients with a history of interstitial lung disease.
Croatian: Rizik od njihove pojave može biti povišen u bolesnika s intersticijskom bolesti pluća u anamnezi.
English: • cefaclor, benzylpenicillin (penicillin G), ciprofloxacin for infections
Croatian: • cefaklor, benzilpenicilin (penicilin G), ciprofloksacin, za liječenje infekcija
English: In a small prospective study in women (n = 64) who became inadvertently pregnant while taking leflunomide for no more than three weeks after conception and followed by a drug elimination procedure, no significant differences (p = 0.13) were observed in the overall rate of major structural defects (5.4 %) compared to either of the comparison groups (4.2 % in the disease matched group [n = 108] and 4.2 % in healthy pregnant women [n = 78]).
Croatian: U manjem prospektivnom ispitivanju u žena (n = 64) koje su neplanirano ostale u drugom stanju dok su uzimale leflunomid u trajanju od ne više od tri tjedna nakon začeća i nakon postupka eliminacije lijeka nisu zabilježene značajne razlike (p = 0,13) u cjelokupnoj stopi većih strukturnih oštećenja (5,4 %) u odnosu na bilo koju od komparativnih skupina (4,2 % u bolesnih žena [n = 108] i 4,2 % u zdravih trudnica [n = 78]).
English: • if you experience weakness, feel light-headed or dizzy or have difficulty breathing, as these may be signs of a serious allergic reaction,
Croatian: • ako osjetite slabost, ošamućenost ili omaglicu ili imate poteškoće s disanjem, jer to mogu biti znaci ozbiljne alergijske reakcije.
English: Leflunomide medac is contraindicated in pregnancy (see section 4.3).
Croatian: Leflunomid medac je kontraindiciran u trudnoći (vidjeti dio 4.3).
English: If you suspect that you are pregnant while taking Leflunomide medac or in the two years after you have stopped treatment, you must contact your doctor immediately for a pregnancy test.
Croatian: Ako sumnjate da ste trudni dok uzimate Leflunomid medac ili da ste zatrudnjeli u posljednje dvije godine nakon prekida liječenja, odmah se obratite liječniku kako bi se proveo test na trudnoću.
English: Leflunomide medac tablets should be swallowed whole with sufficient amounts of liquid.
Croatian: Leflunomid medac tablete treba progutati cijele s dovoljnom količinom tekućine.
English: • tizanidine, a muscle relaxant
Croatian: • tizanidin, lijek za opuštanje mišića
English: The treatment should be initiated and supervised by specialists experienced in the treatment of rheumatoid arthritis and psoriatic arthritis.
Croatian: Liječenje mora započeti i nadzirati liječnik specijalist s iskustvom u liječenju reumatoidnog artritisa i psorijatičnog artritisa.
English: • mild allergic reactions,
Croatian: • blage alergijske reakcije,
English: • if you have any liver problems,
Croatian: • ako imate probleme s jetrom,
English: • an increase in some liver results which may develop into serious conditions such as hepatitis and jaundice,
Croatian: • porast jetrenih enzima što se može razviti u ozbiljno stanje poput hepatitisa i žutice,
English: • if you are suffering from a serious infection,
Croatian: • ako imate jaku infekciju,
English: What Leflunomide medac is and what it is used for
Croatian: Što je Leflunomid medac i za što se koristi
English: Interstitial lung disease, as well as rare cases of pulmonary hypertension have been reported during treatment with leflunomide (see section 4.8).
Croatian: Intersticijska bolest pluća, kao i rijetki slučajevi plućne hipertenzije prijavljeni su tijekom liječenja leflunomidom (vidjeti dio 4.8).
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the bottle after EXP.
Croatian: Ovaj lijek ne smije se upotrijebiti nakon isteka roka valjanosti navedenog na vanjskom pakovanju i na boci iza oznake „Rok valjanosti“.
English: A771726 displaced ibuprofen, diclofenac and tolbutamide but the unbound fraction of these drugs is only increased by 10 % to 50 %.
Croatian: A771726 istiskuje ibuprofen, diklofenak i tolbutamid, ali se nevezana frakcija tih lijekova povećava za samo 10 % do 50 %.
English: Leflunomide medac belongs to a group of medicines called anti-rheumatic medicines.
Croatian: Leflunomid medac pripada skupini lijekova koji se zovu antireumatski lijekovi.
English: For ALT (SGPT) elevations between 2- and 3-fold the upper limit of normal, dose reduction to 10 mg may be considered and monitoring must be performed weekly.
Croatian: Kad se ALT (SGPT) poveća 2 do 3 puta u odnosu na gornju granicu normale, može se razmotriti smanjenje doze na 10 mg, a vrijednosti se moraju kontrolirati jednom na tjedan.
English: Drinking alcohol while taking Leflunomide medac may increase the chance of liver damage.
Croatian: Uzimanje alkohola za vrijeme liječenja Leflunomidom medac može povećati mogućnost oštećenja jetre.
English: • nausea, vomiting,
Croatian: • mučnina, povraćanje,
English: In a study with radiolabelled
Croatian: U ispitivanjima radioaktivno obilježenog
English: The efficacy of leflunomide was confirmed in this study, but no incremental overall benefit was observed in the studied population with the use of a loading dose regimen.
Croatian: U ovom je ispitivanju potvrđena djelotvornost leflunomida, ali nije zabilježen porast cjelokupne koristi u ispitivanoj populaciji koja je dobivala udarnu dozu.
English: As leflunomide has a long persistence in the body, a switching to another DMARD (e.g. methotrexate) without performing the washout procedure (see below) may raise the possibility of additive risks even for a long time after the switching (i.e. kinetic interaction, organ toxicity).
Croatian: Kako se leflunomid dugo zadržava u tijelu, prijelaz na neki drugi DMARD (npr. metotreksat) bez provođenja postupka ispiranja (vidjeti nastavak teksta) može povećati mogućnost pojave dodatnih rizika, čak i dugo nakon promjene lijeka (npr. kinetička interakcija, organska toksičnost).
English: However, also following either of the washout procedures, verification by 2 separate tests at an interval of at least 14 days and a waiting period of one-and-a-half months between the first occurrence of a plasma concentration below 0.02 mg/l and fertilisation is required.
Croatian: Međutim, nakon primjene bilo kojeg od navedenih postupaka ispiranja, potrebno je provjeriti koncentraciju u plazmi na osnovi dva testa provedena u razmaku od najmanje 14 dana i uz razdoblje čekanja od najmanje mjesec i pol između prvog nalaza koncentracije u plazmi niže od 0,02 mg/l i začeća.
English: Film-coating: lecithin (soybeans) poly(vinyl alcohol) talc titanium dioxide (E 171) xanthan gum
Croatian: Film ovojnica: lecitin (sojin) poli(vinilni alkohol) talk titanijev dioksid (E 171) ksantanska guma
English: This metabolite is responsible for essentially all the in-vivo activity of Leflunomide medac.
Croatian: Taj je metabolit odgovoran za gotovo svu in vivo aktivnost lijeka Leflunomid medac.
English: • any symptoms of an infection such as fever, sore throat or cough, as this medicine may increase the chance of a severe infection which may be life-threatening,
Croatian: • bilo kojeg simptoma infekcije kao što su vrućica, grlobolja ili kašalj, jer ovaj lijek može povećati rizik od teških infekcija koje mogu biti opasne po život.
English: If a patient taking Leflunomide medac develops a peripheral neuropathy, consider discontinuing Leflunomide medac therapy and performing the drug elimination procedure (see section 4.4).
Croatian: Ako se u bolesnika koji uzima Leflunomid medac pojavi periferna neuropatija, treba razmotriti prestanak terapije lijekom Leflunomid medac i provođenje postupka eliminacije lijeka (vidjeti dio 4.4).
English: • if you have ever suffered from interstitial lung disease,
Croatian: • ako ste ikad imali intersticijsku plućnu bolest.
English: Skin reactions In case of ulcerative stomatitis, leflunomide administration should be discontinued.
Croatian: Kožne reakcije U slučaju pojave ulceroznog stomatitisa primjenu leflunomida treba prekinuti.
English: For washout procedures and other recommended actions in case of desired or unintended pregnancy,
Croatian: Za postupak ispiranja i ostale preporučene aktivnosti u slučaju željene ili neplanirane trudnoće vidjeti dio 4.6.
English: The Marketing Authorisation Holder (MAH) shall ensure that all physicians who are expected to prescribe/use Leflunomide medac are provided with a physician educational pack containing the following:
Croatian: Nositelj odobrenja za stavljanje gotovog lijeka u promet dužan je osigurati da svi liječnici koji bi mogli propisivati/upotrebljavati Leflunomid medac dobiju edukacijski komplet za liječnike koji sadržava sljedeće:
English: What Leflunomide medac is and what it is used for What you need to know before you take Leflunomide medac How to take Leflunomide medac Possible side effects
Croatian: Što je Leflunomid medac i za što se koristi Što morate znati prije nego što počnete uzimati Leflunomid medac Kako uzimati Leflunomid medac
English: • teriflunomide for multiple sclerosis
Croatian: • Teriflunomid za liječenje multiple skleroze
English: • an increase in the levels of fat in the blood (cholesterol and triglycerides),
Croatian: • povećanje razine masnoća u krvi (kolesterol i trigliceridi),
English: Men wishing to father a child should contact their doctor who may advise them to stop taking Leflunomide medac and take certain medicines to remove Leflunomide medac rapidly and sufficiently from their body.
Croatian: Muškarci koji žele postati roditelji trebaju se obratiti svom liječniku koji im može savjetovati da prestanu uzimati Leflunomid medac i uzmu određene lijekove koji će brzo i zadovoljavajuće ukloniti Leflunomid medac iz tijela.
English: • severe infections called sepsis which may be fatal,
Croatian: • teška infekcija koja se zove sepsa i može imati smrtni ishod,
English: If you are pregnant or become pregnant while taking Leflunomide medac, the risk of having a baby with serious birth defects is increased.
Croatian: Ako ste trudni ili zatrudnite dok uzimate Leflunomid medac, rizik od ozbiljnih prirođenih mana u Vašeg djeteta je povećan.
English: Leflunomide medac is used to treat adult patients with active rheumatoid arthritis or with active psoriatic arthritis.
Croatian: Leflunomid medac se primjenjuje za liječenje odraslih bolesnika s aktivnim oblikom reumatoidnog artritisa ili aktivnim oblikom psorijatičnog artritisa.
English: Moreover, switching from leflunomide to another DMARD without following the washout procedure (see section 4.4) may also increase the risk of serious adverse reactions even for a long time after the switching.
Croatian: Osim toga, prijelaz s leflunomida na neki drugi DMARD, bez provedbe postupka ispiranja („washout“) leflunomida (vidjeti dio 4.4.), također može povećati rizik od ozbiljnih nuspojava, čak i dulje vrijeme nakon promjene lijeka.
English: • cough or breathing problems as these may indicate problems of the lung (interstitial lung disease or pulmonary hypertension),
Croatian: • kašlja ili problema s disanjem budući da ovi problemi mogu ukazivati na probleme s plućima (intersticijska plućna bolest ili plućna hipertenzija).
English: The results of a population pharmacokinetic analysis of these trials have demonstrated that paediatric patients with body weights ≤ 40 kg have a reduced systemic exposure (measured by Css) of A771726 relative to adult rheumatoid arthritis patients (see section 4.2).
Croatian: Rezultati populacijske farmakokinetičke analize tih ispitivanja pokazuju da su pedijatrijski bolesnici tjelesne težine ≤ 40 kg imali smanjenu sistemsku izloženost (mjerenu s Css) A771726 u odnosu na odrasle bolesnike s reumatoidnim artritisom (vidjeti dio 4.2.).
English: • Hypersensitivity (especially previous Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme) to the active substance, to the principal active metabolite teriflunomide, peanut or soya or to any of the excipients listed in section 6.1.
Croatian: • Preosjetljivost (osobito u slučaju ranijeg Stevens-Johnsonovog sindroma, toksične epidermalne nekrolize, multiformnog eritema) na djelatnu tvar, na glavni aktivni metabolit teriflunomid, kikiriki ili soju ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: What you need to know before you take Leflunomide medac
Croatian: Što morate znati prije nego što počnete uzimati Leflunomid medac
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 27 July 2010
Croatian: Datum prvog odobrenja: 27 srpanj 2010
English: pancytopenia (probably by antiproliferative mechanism), leucopenia (leucocytes < 2 G/l), eosinophilia
Croatian: pancitopenija (vjerojatno povezana s antiproliferativnim mehanizmom djelovanja), leukopenija (leukociti < 2 g/l), eozinofilija
English: Increased side effects may occur in case of recent or concomitant use of hepatotoxic or haematotoxic drugs or when leflunomide treatment is followed by such drugs without a washout period (see also guidance concerning combination with other treatments, section 4.4).
Croatian: Više nuspojava može se pojaviti u slučaju nedavne ili istodobne primjene hepatotoksičnih ili hematotoksičnih lijekova ili kad se nakon primjene takvih lijekova leflunomid primjenjuje bez perioda ispiranja (vidjeti upute o kombinaciji s ostalim lijekovima, dio 4.4.).
English: If you are already taking a non-steroidal anti-inflammatory drug (NSAID) and/or corticosteroids, you may continue to take them after starting Leflunomide medac.
Croatian: Ako već uzimate nesteroidne protuupalne lijekove (NSAIL) i/ili kortikosteroide, možete ih nastaviti uzimati nakon što počnete uzimati Leflunomid medac.
English: The usual starting dosage of Leflunomide medac is 100 mg once daily for the first three days.
Croatian: Uobičajena početna doza lijeka Leflunomid medac je 100 mg jedanput na dan tijekom prva 3 dana.
English: Vaccination with live attenuated vaccines is, however, not recommended.
Croatian: Međutim, ne preporučuje se cijepljenje živim atenuiranim cjepivima.
English: • a decrease in the levels of phosphate in the blood.
Croatian: • smanjenje razine fosfata u krvi.
English: • The other ingredients are lactose monohydrate, low-substituted hydroxypropyl cellulose, tartaric acid, sodium laurylsulfate and magnesium stearate in the tablet core as well as lecithin (soybeans), poly(vinyl alcohol), talc, titanium dioxide (E 171) and xanthan gum in the film-coating.
Croatian: • Ostali sastojci su laktoza hidrat, niskosupstituirana hidroksipropilceluloza, tartarna kiselina, natrijev laurilsulfat i magnezijev stearat u jezgri tablete kao i lecitin (sojin), poli(vinilni alkohol), talk, titanijev dioksid (E 171) i ksantanska guma u film ovojnici.
English: You will then need a blood test to make sure that Leflunomide medac has been sufficiently removed from your body, and you should then wait for at least another 3 months before attempting to father a child.
Croatian: Trebat ćete napraviti krvne pretrage kako biste bili sigurni da je Leflunomid medac u dovoljnoj mjeri uklonjen iz tijela i nakon toga pričekati najmanje sljedeća 3 mjeseca prije pokušaja ostvarivanja očinstva.
English: Effect of leflunomide on other medicinal products:
Croatian: Utjecaj leflunomida na druge lijekove:
English: • theophylline for asthma
Croatian: • teofilin za liječenje astme
English: If you take more Leflunomide medac than you should If you take more Leflunomide medac than you should, contact your doctor or get other medical advice.
Croatian: Ako uzmete više lijeka Leflunomid medac nego što ste trebali, obratite se svom liječniku ili potražite liječničku pomoć.
English: • daunorubicin, doxorubicin, paclitaxel, or topotecan for cancer
Croatian: • daunorubicin, doksorubicin, paklitaksel ili topotekan za liječenje raka
English: • an increase of certain enzymes in the blood (lactate dehydrogenase).
Croatian: • povećanje određenih enzima u krvi (enzima laktat dehidrogenaze).
English: • Patients with significantly impaired bone marrow function or significant anaemia, leucopenia, neutropenia or thrombocytopenia due to causes other than rheumatoid or psoriatic arthritis.
Croatian: • Bolesnici sa značajno oštećenom funkcijom koštane srži ili izraženom anemijom, leukopenijom, neutropenijom ili trombocitopenijom, koje nisu uzrokovane reumatoidnim artritisom ili psorijatičnim artritisom.
English: • a medicine called colestyramine (used to reduce high cholesterol) or activated charcoal as these medicines can reduce the amount of Leflunomide medac which is absorbed by the body.
Croatian: • sulfasalazin za liječenje upalne bolesti crijeva ili reumatoidnog artritisa lijek zvan kolestiramin (za smanjenje kolesterola u krvi) ili aktivni ugljen, jer ti lijekovi mogu smanjiti količinu lijeka Leflunomid medac koju apsorbira tijelo.
English: Due to the very long half-life of A771726 (approximately 2 weeks), a loading dose of 100 mg for 3 days was used in clinical studies to facilitate the rapid attainment of steady-state levels of A771726.
Croatian: Zbog veoma dugog poluvijeka A771726 (oko 2 tjedna) u kliničkim je ispitivanjima primjenjivana udarna doza od 100 mg tijekom 3 dana kako bi se ubrzalo postizanje stanja dinamičke ravnoteže A771726.
English: The ACR (American College of Rheumatology) response rates in study YU203 were 27.7 % for placebo, 31.9 % for 5 mg, 50.5 % for 10 mg and 54.5 % for 25 mg/day.
Croatian: Stope terapijskog odgovora prema ACR-u (American College of Rheumatology) u studiji YU203 bile su 27,7 % za placebo, 31,9 % za 5 mg/dan, 50,5 % za 10 mg/dan i 54,5 % za 25 mg/dan.
English: • a decrease in the number of red blood cells (anaemia) and a decrease in the number of blood platelets (thrombocytopenia),
Croatian: • smanjen broj crvenih krvnih stanica (anemija) i smanjen broj krvnih pločica (trombocitopenija),
English: Cases of peripheral neuropathy have been reported in patients receiving Leflunomide medac.
Croatian: Slučajevi periferne neuropatije zabilježeni su u bolesnika koji su uzimali Leflunomid medac.
English: • pale skin, tiredness, or bruising, as these may indicate blood disorders caused by an imbalance in the different types of blood cells which make up blood,
Croatian: • bljedoće kože, umora ili pojave modrica, jer to može upućivati na krvne poremećaje uzrokovane poremećenom ravnotežom različitih vrsta krvnih stanica.
English: For other substrates of BCRP (e.g. methotrexate, topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA reductase inhibitors (e.g. simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide, repaglinide, rifampicin) concomitant administration should also be undertaken with caution.
Croatian: Za ostale supstrate BCRP (npr. metotreksat, topotekan, sulfasalazin, daunorubicin, doksorubicin) i OATP porodice, osobito inhibitore HMG-CoA reduktaze (npr. simvastatin, atorvastatin, pravastatin, metotreksat, nateglinid, repaglinid, rifampicin), istodobna primjena se također mora provoditi uz oprez.
English: • if you are due to have a specific blood test (calcium level).
Croatian: • ako morate napraviti određenu krvnu pretragu (utvrđivanje razine kalcija).
English: Effect of other medicinal products on leflunomide:
Croatian: Utjecaj drugih lijekova na leflunomid:
English: • Alternatively, 50 g of activated powdered charcoal is administered 4 times daily for a period of 11 days.
Croatian: • Alternativno, 50 g aktivnog ugljena u prahu 4 puta na dan tijekom 11 dana.
English: • unusual tingling, weakness or pain in your hands or feet as these may indicate problems with your nerves (peripheral neuropathy).
Croatian: • neuobičajenih trnaca, slabosti li bolova u šakama ili stopalima, jer mogu upućivati na probleme sa živcima (periferna neuropatija).
English: severe anaphylactic/anaphylactoid reactions, vasculitis, including cutaneous necrotizing vasculitis
Croatian: teške anafilaktične/anafilaktoidne reakcije, vaskulitis, uključujući kožni nekrotizirajući vaskulitis
English: Leflunomide medac is contraindicated in patients with severe hypoproteinaemia or impairment of liver function (see section 4.3).
Croatian: Leflunomid medac je kontraindiciran u bolesnika s teškom hipoproteinemijom ili oštećenom jetrenom funkcijom (vidjeti dio 4.3.).
English: • abnormal skin sensations like tingling (paraesthesia),
Croatian: • nenormalni osjeti na koži poput trnaca (parestezije),
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING BOTTLE PACK
Croatian: PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKIRANJU BOCA
English: If such effects occur, a washout (see below) to reduce plasma levels of A771726 should be considered.
Croatian: Ako se ti učinci pojave, treba razmotriti postupak ispiranja (vidjeti nastavak teksta) kako bi se smanjila koncentracija A771726 u plazmi.
English: However, a 25 % decrease in peak international normalised ratio (INR) was observed when A771726 was co-administered with warfarin as compared with warfarin alone.
Croatian: Ipak, primjećeno je 25 %-tno smanjenje vršne vrijednosti internacionalnog normaliziranog omjera (INR) kod istodobne primjene A771726 s varfarinom, u usporedbi s monoterapijom varfarinom.
English: • severe sometimes life-threatening reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme).
Croatian: • teške reakcije koje ponekad mogu biti opasne po život (Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, multiformni eritem).