FrancophonIA/ELRC3.0 huggingface dataset:
English: Recommendation Concerning Co-administration with doravirine/lamivudine/tenofo vir disoproxil ledipasvir + sofosbuvir (90 mg ledipasvir SD + 400 mg sofosbuvir SD, doravirine 100 mg SD)
Croatian: Preporuka za istodobnu primjenu s doravirinom/ lamivudinom/ tenofovirdizoproksilom ledipasvir + sofosbuvir (ledipasvir 90 mg SD + sofosbuvir 400 mg SD, doravirin 100 mg SD)
English: Uncommon myalgia, arthralgia, rhabdomyolysis* muscular weakness*
Croatian: manje često mialgija, artralgija, rabdomioliza* †, slabost u mišićima*
English: There were no effects on fertility, mating performance or early embryonic development when doravirine was administered to rats at up to 7 times the exposure in humans at the RHD.
Croatian: Nije bilo učinaka na plodnost, sposobnost parenja ni rani razvoj zametka kada se doravirin primjenjivao štakorima u dozama pri kojima su postignute razine izloženosti do 7 puta veće od onih koje se postižu u ljudi kod primjene preporučene doze za ljude.
English: Binding to plasma protein is low.
Croatian: Lamivudin se u maloj mjeri vezuje za proteine u plazmi.
English: + T'.
Croatian: T stanice“.
English: No clinically relevant pharmacokinetic differences have been identified between men and women for doravirine, lamivudine, and tenofovir.
Croatian: Nisu utvrđene klinički značajne razlike u farmakokinetici doravirina, lamivudina i tenofovira između muškaraca i žena.
English: No dose adjustment is required in patients with mild or moderate hepatic impairment.
Croatian: Nije potrebno prilagođavati dozu u bolesnika s blagim ili umjerenim oštećenjem funkcije jetre.
English: The tablets are film-coated with a coating material containing the following ingredients: carnauba wax E903, hypromellose E464; iron oxide yellow E172; lactose monohydrate; titanium dioxide E171; and triacetin E1518.
Croatian: Tablete su obložene film ovojnicom koja sadrži sljedeće sastojke: karnauba vosak (E903), hipromelozu (E464), žuti željezov oksid (E172), laktozu hidrat, titanijev dioksid (E171) i triacetin (E1518).
English: • Keep the bottle tightly closed in order to protect from moisture.
Croatian: • Bocu čuvajte čvrsto zatvorenom radi zaštite od vlage.
English: St. John's wort (Hypericum perforatum)
Croatian: Biljni pripravci gospina trava (Hypericum perforatum)
English: Therefore, cross-resistance among these NRTIs may occur in patients whose virus harbours the K65R substitution.
Croatian: Stoga je u bolesnika zaraženih virusom koji sadrži supstituciju K65R moguća križna rezistencija između tih NRTI-ja.
English: Animal studies with doravirine do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3).
Croatian: Ispitivanja doravirina na životinjama ne ukazuju na izravan ili neizravan štetan učinak na reprodukciju (vidjeti dio 5.3).
English: Week 48 and 96 outcomes for DRIVE-FORWARD and DRIVE-AHEAD are provided in Table 4.
Croatian: Ishodi u 48. i 96. tjednu ispitivanja DRIVE-FORWARD i DRIVE-AHEAD prikazani su u Tablici 4. Režimi temeljeni na doravirinu pokazali su dosljednu djelotvornost kod svih demografskih te početnih prognostičkih faktora.
English: • Doravirine - a non-nucleoside reverse transcriptase inhibitor (NNRTI)
Croatian: • doravirin - nenukleozidni inhibitor reverzne transkriptaze (engl. non-nucleoside reverse transcriptase inhibitor, NNRTI)
English: Animal studies with tenofovir disoproxil do not indicate direct or indirect harmful effects of tenofovir disoproxil with respect to reproductive toxicity (see section 5.3).
Croatian: Ispitivanja tenofovirdizoproksila na životinjama ne ukazuju na izravan ili neizravan štetan učinak tenofovirdizoproksila na reprodukciju (vidjeti dio 5.3).
English: lamivudine + tenofovir disoproxil (300 mg lamivudine SD + 245 mg tenofovir disoproxil SD, doravirine 100 mg SD)
Croatian: lamivudin + tenofovirdizoproksil (lamivudin 300 mg SD + tenofovirdizoproksil 245 mg SD, doravirin 100 mg SD)
English: Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α, β, and mitochondrial DNA polymerase γ.
Croatian: Tenofovirdifosfat je slab inhibitor DNK polimeraza α i β u sisavaca te mitohondrijske DNK polimeraze γ.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Croatian: prijavljeno vrijeme do nastanka je jako varijabilno, te ovi događaji mogu nastati puno mjeseci nakon početka liječenja (vidjeti dio 4.4).
English: New onset or worsening renal impairment
Croatian: Razvoj ili pogoršanje oštećenja funkcije bubrega
English: 5, abdominal distension, dyspepsia, faeces soft gastrointestinal motility disorder
Croatian: 5, distenzija abdomena, dispepsija, mekana stolica
English: DOR + 2 NRTIs (383) DRV+r + 2 NRTIs
Croatian: DRV+r + 2 NRTIja (383)
English: What Delstrigo is used for
Croatian: Za što se Delstrigo koristi
English: Gastrointestinal disorders Common nausea, diarrhoea, abdominal pain 4, vomiting,
Croatian: Poremećaji probavnog sustava često mučnina, proljev, bol u abdomenu 4, povraćanje,
English: Interaction not studied with doravirine or doravirine/lamivudine/tenofovir disoproxil.
Croatian: Nije se ispitivala interakcija s doravirinom ili doravirinom/lamivudinom/ tenofovirdizoproksilom.
English: • constipation, stomach discomfort, swollen or bloated stomach (abdominal distention),
Croatian: • zatvor, nelagoda u trbuhu, natečen ili nadut trbuh (distenzija abdomena), probavne smetnje,
English: In in vitro studies, doravirine was able to suppress the following NNRTI-associated substitutions; K103N, Y181C, and G190A under clinically relevant concentrations.
Croatian: U ispitivanjima in vitro doravirin je u klinički značajnim koncentracijama uspio suprimirati sljedeće supstitucije povezane s rezistencijom na NNRTI-je: K103N, Y181C i G190A.
English: If you have been told by your doctor that you have an intolerance to lactose, talk to your doctor before taking this medicine.
Croatian: Delstrigo tablete sadrže laktozu Ako Vam je liječnik rekao da ne podnosite laktozu, obratite se liječniku prije uzimanja ovog lijeka.
English: • trouble concentrating, memory problems, tingling of hands and feet, stiff muscles, poor quality of sleep
Croatian: • poteškoće s koncentracijom, poteškoće s pamćenjem, trnci u šakama i stopalima, ukočeni mišići,
English: • 90 film-coated tablets (3 bottles of 30 film-coated tablets)
Croatian: • 90 filmom obloženih tableta (3 boce s 30 filmom obloženih tableta)
English:  doravirine AUC 3.06 (2.85, 3.29) Cmax 1.25 (1.05, 1.49) C24 2.75 (2.54, 2.98) (Inhibition of CYP3A)
Croatian: AUC 3,06 (2,85; 3,29) Cmax 1,25 (1,05; 1,49) C24 2,75 (2,54; 2,98) (inhibicija CYP3A)
English: • Tenofovir disoproxil - a nucleoside analogue reverse transcriptase inhibitor (NRTI)
Croatian: • tenofovirdizoproksil - analog nukleozida, inhibitor reverzne transkriptaze (NRTI)
English: When Delstrigo is co-administered with rifabutin, a 100 mg dose of doravirine should be given daily, approximately 12 hours after doravirine/lamivudine/tenofovir disoproxil dose (see section 4.2).
Croatian: Kada se Delstrigo istodobno primjenjuje s rifabutinom, potrebno je primijeniti dozu doravirina od 100 mg na dan, približno 12 sati nakon doze doravirina/lamivudina/tenofovirdizoproksila (vidjeti dio 4.2).
English: Do not run out of Delstrigo.
Croatian: Nemojte uzimati Delstrigo
English: • bosentan (a medicine to treat lung disease)
Croatian: • bosentan (lijek za liječenje bolesti pluća)
English: NNRTI substitutions and use of doravirine
Croatian: Supstitucije povezane s rezistencijom na NNRTI-je i primjena doravirina
English: Delstrigo 100 mg / 300 mg / 245 mg film-coated tablets doravirine/lamivudine/tenofovir disoproxil
Croatian: Delstrigo 100 mg/300 mg/245 mg filmom obložene tablete doravirin/lamivudin/tenofovirdizoproksil
English: Rare aggression, hallucination, adjustment disorder, mood altered, somnambulism
Croatian: 2, anksioznost razdražljivost, konfuzno stanje, suicidalne misli rijetko agresivnost, halucinacija, poremećaj prilagodbe, promjena raspoloženja, somnambulizam
English: Observed emergent amino acid substitutions in RT included: V106A, V106M, V106I, V108I, F227L, F227C, F227V, H221Y, M230I, L234I, P236L, and Y318F.
Croatian: Opažene aminokiselinske supstitucije u reverznoj transkriptazi koje su se pojavile tijekom liječenja uključivale su sljedeće: V106A, V106M, V106I, V108I, F227L, F227C, F227V, H221Y, M230I, L234I, P236L i Y318F.
English: Pharmacokinetic parameters were not altered by diminishing hepatic function.
Croatian: Smanjenje funkcije jetre nije utjecalo na farmakokinetičke parametre.
English: No clinically relevant differences in tenofovir pharmacokinetics were observed between subjects with hepatic impairment and healthy subjects.
Croatian: Nisu opažene klinički značajne razlike u farmakokinetici tenofovira između ispitanika s oštećenjem funkcije jetre i zdravih ispitanika.
English: 12 hours, skip the dose you missed and take the next one at the usual time.
Croatian: Međutim, ako je do sljedeće doze preostalo manje od 12 sati, preskočite propuštenu dozu i uzmite sljedeću predviđenu dozu u uobičajeno vrijeme.
English: Hepatitis C Antiviral Agents elbasvir + grazoprevir (50 mg elbasvir QD + 200 mg grazoprevir QD, doravirine 100 mg QD)
Croatian: elbasvir + grazoprevir (elbasvir 50 mg QD + grazoprevir 200 mg QD, doravirin 100 mg QD)
English: How to take Delstrigo
Croatian: Kako uzimati Delstrigo
English: If doravirine/ lamivudine/ tenofovir disoproxil is coadministered with rifabutin, a 100 mg dose of doravirine should be taken daily, approximately 12 h after dose of doravirine/lamivudine/tenofovir disoproxil.
Croatian: Ako se doravirin/lamivudin/ tenofovirdizoproksil primjenjuje istodobno s rifabutinom, treba uzimati dozu doravirina od 100 mg na dan, približno 12 sati nakon doze doravirina/ lamivudina/tenofovirdizoproksila.
English:  doravirine AUC 1.56 (1.45, 1.68) Cmax 1.41 (1.25, 1.58) C24 1.61 (1.45, 1.79) (Inhibition of CYP3A)
Croatian: AUC 1,56 (1,45; 1,68) Cmax 1,41 (1,25; 1,58) C24 1,61 (1,45; 1,79) (inhibicija CYP3A)
English: Immune reactivation syndrome has been reported in patients treated with combination antiretroviral therapy.
Croatian: U bolesnika liječenih kombiniranom antiretrovirusnom terapijom prijavljen je sindrom imunološke reaktivacije.
English: ↑ doravirine AUC 1.15 (1.07, 1.24) Cmax 1.11 (0.97, 1.27) C24 1.24 (1.13, 1.36)
Croatian: AUC 1,15 (1,07; 1,24) Cmax 1,11 (0,97; 1,27) C24 1,24 (1,13; 1,36)
English: • decreased levels of haemoglobin
Croatian: • snižene vrijednosti hemoglobina
English: Package leaflet: Information for the user Delstrigo 100 mg/300 mg/245 mg film-coated tablets doravirine/ lamivudine/ tenofovir disoproxil
Croatian: Uputa o lijeku: Informacije za korisnika Delstrigo 100 mg/300 mg/245 mg filmom obložene tablete doravirin / lamivudin / tenofovirdizoproksil
English: Opioid Analgesics methadone (20-200 mg QD individualised dose, doravirine 100 mg QD)
Croatian: Opioidni analgetici metadon (individualizirana doza od 20 - 200 mg QD, doravirin 100 mg QD)
English: Cases of osteomalacia associated with proximal renal tubulopathy, manifested as bone pain or pain in extremities and which may contribute to fractures, have been reported in association with the use of tenofovir disoproxil .
Croatian: Kod primjene tenofovirdizoproksila prijavljeni su slučajevi osteomalacije povezane s proksimalnom bubrežnom tubulopatijom, koja se manifestirala kao bol u kostima ili bol u ekstremitetima i koja može pridonijeti prijelomima.
English: • The other ingredients are croscarmellose sodium E468; hypromellose acetate succinate; magnesium stearate E470b; microcrystalline cellulose E460; silica, colloidal anhydrous E551; sodium stearyl fumarate.
Croatian: • Drugi sastojci su umrežena karmelozanatrij (E468), hipromeloza acetat sukcinat, magnezijev stearat (E470b), mikrokristalična celuloza (E460), bezvodni koloidni silicijev dioksid (E551) i natrijev stearilfumarat.
English: Proportion (%) of Subjects With HIV-1 RNA < 40 copies/mL by Baseline Regimen Received
Croatian: Omjer (%) ispitanika s HIV-1 RNK < 40 kopija/ml prema primljenom početnom režimu
English: In addition, a K70E substitution in HIV-1 RT has been selected by tenofovir and results in low-level reduced susceptibility to abacavir, emtricitabine, lamivudine, and tenofovir.
Croatian: Osim toga, tenofovirom je izdvojena i supstitucija K70E u reverznoj transkriptazi HIV-1, koja blago smanjuje osjetljivost na abakavir, emtricitabin, lamivudin i tenofovir.
English: Croscarmellose sodium (E468) Hypromellose acetate succinate Magnesium stearate (E470b) Microcrystalline cellulose (E460) Silica, colloidal anhydrous (E551) Sodium stearyl fumarate
Croatian: Jezgra tablete karmelozanatrij, umrežena (E468) hipromeloza acetat sukcinat magnezijev stearat (E470b) celuloza, mikrokristalična (E460) silicijev dioksid, koloidni, bezvodni (E551) natrijev stearilfumarat
English: Expected:  doravirine (Inhibition of CYP3A due to ritonavir)
Croatian: Očekivano: ↑ doravirin (inhibicija CYP3A zbog ritonavira)
English: HIV-1 RNA ≥ 40 copies/mL
Croatian: HIV-1 RNK ≥ 40 kopija/ml
English:  doravirine
Croatian: Doravirin
English: Proportion (%) of Subjects With HIV-1 RNA < 40 copies/mL by Baseline CD4
Croatian: Omjer (%) ispitanika s HIV-1 RNK < 40 kopija/ml prema broju CD4
English: Based on administration of an IV microdose, the volume of distribution of doravirine is 60.5 L. Doravirine is approximately 76 % bound to plasma proteins.
Croatian: Na temelju primjene intravenske mikrodoze utvrđeno je da volumen distribucije doravirina iznosi 60,5 l.
English: Emergent doravirine associated resistance substitutions in RT included one or more of the following: A98G, V106I, V106A, V106M/T, Y188L, H221Y, P225H, F227C, F227C/R, and Y318Y/F.
Croatian: Supstitucije u reverznoj transkriptazi povezane s rezistencijom na doravirin koje su se pojavile tijekom liječenja uključivale su jednu ili više sljedećih supstitucija: A98G, V106I, V106A, V106M/T, Y188L, H221Y, P225H, F227C, F227C/R i Y318Y/F.
English: HIV-1 RNA < 40 copies/mL
Croatian: HIV-1 RNK < 40 kopija/ml
English: HIV-1 RNA copies/mL
Croatian: HIV-1 RNK kopija/ml
English: A panel of 96 diverse clinical isolates containing NNRTI-associated mutations was evaluated for susceptibility to doravirine in the presence of 10 % foetal bovine serum.
Croatian: Kako bi se utvrdila osjetljivost na doravirin u prisutnosti 10%-tnog fetalnog goveđeg seruma, ocijenjen je panel od 96 različitih kliničnih izolata koji su sadržavali mutacije povezane s rezistencijom na NNRTI-je.
English: Psychiatric disorders Common abnormal dreams, insomnia
Croatian: Psihijatrijski poremećaji često neuobičajeni snovi, nesanica manje često noćna mora, depresija
English:  doravirine AUC 0.50 (0.45, 0.55) Cmax 0.99 (0.85, 1.15) C24 0.32 (0.28, 0.35) (Induction of CYP3A)
Croatian: AUC 0,50 (0,45; 0,55) Cmax 0,99 (0,85; 1,15) C24 0,32 (0,28; 0,35) (indukcija CYP3A)
English: • feeling tired, fever
Croatian: • umor, vrućica
English: • Lamivudine - a nucleoside analogue reverse transcriptase inhibitor (NRTI)
Croatian: • lamivudin - analog nukleozida, inhibitor reverzne transkriptaze (engl. nucleoside reverse transcriptase inhibitor, NRTI)
English: Blood tests may also show: • failure of the bone marrow to produce new red blood cells (pure red cell aplasia)
Croatian: • nesposobnost koštane srži da proizvede nove crvene krvne stanice (izolirana aplazija crvenih krvnih stanica)
English: See “Other medicines and Delstrigo” section for a list of medicines.
Croatian: Za popis lijekova pogledajte odlomak „Drugi lijekovi i Delstrigo“.
English: Some patients have had blood tests or symptoms indicating that their hepatitis has worsened after stopping lamivudine or tenofovir disoproxil (two of the three active substances of Delstrigo).
Croatian: Neki su bolesnici nakon prestanka primjene lamivudina ili tenofovirdizoproksila (dviju od tri djelatne tvari u lijeku Delstrigo) imali nalaze krvnih pretraga ili simptome koji ukazuju na pogoršanje hepatitisa.
English: Statins atorvastatin (20 mg SD, doravirine 100 mg QD)
Croatian: Statini atorvastatin (20 mg SD, doravirin 100 mg QD)
English: Rare hypomagnesaemia, lactic acidosis*
Croatian: rijetko hipomagnezijemija, laktacidoza*
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: Combination antiretroviral therapy, CART) može nastati upalna reakcija na asimptomatske ili rezidualne oportunističke patogene.
English: • The active substances are 100 mg of doravirine, 300 mg of lamivudine and 245 mg of tenofovir disoproxil (as fumarate)
Croatian: • Djelatne tvari su 100 mg doravirina, 300 mg lamivudina i 245 mg tenofovirdizoproksila (u obliku fumarata).
English: 0.03 mg ethinyl oestradiol/ 0.15 mg levonorgestrel SD, doravirine 100 mg QD
Croatian: Oralni kontraceptivi etinilestradiol 0,03 mg + levonorgestrel 0,15 mg SD, doravirin 100 mg QD
English: Antidiarrhoeals telotristat ethyl
Croatian: Antidijaroici etiltelotristat
English: Expected: ↓ doravirine (Induction of CYP3A)
Croatian: Očekivano: ↓ doravirin (indukcija CYP3A)
English: Treatment-naïve adult subjects
Croatian: Prethodno neliječeni odrasli ispitanici
English: Table 4: Efficacy response (< 40 copies/mL, Snapshot approach) in the pivotal studies
Croatian: Tablica 4: Odgovor s obzirom na djelotvornost (<40 kopija/ml, pristup utemeljen na algoritmu za globalnu snimku distribuiranog sustava, engl.
English: Patients receiving doravirine/lamivudine/tenofovir disoproxil concomitantly with sofosbuvir/velpatasvir should be monitored for adverse reactions associated with tenofovir disoproxil.
Croatian: Potrebno je pratiti bolesnike koji primaju doravirin/lamivudin/ tenofovirdizoproksil istodobno sa sofosbuvirom/velpatasvirom zbog mogućih nuspojava povezanih s tenofovirdizoproksilom.
English: pantoprazole (40 mg QD, doravirine 100 mg SD)
Croatian: pantoprazol (40 mg QD, doravirin 100 mg SD)
English: Antidiabetics metformin (1000 mg SD, doravirine 100 mg QD)
Croatian: Antidijabetici metformin (1000 mg SD, doravirin 100 mg QD)
English: + T cell count < 200 cells per mm
Croatian: + T-stanica < 200 stanica/mm
English: Expected:  doravirine ↓ tacrolimus, sirolimus (Induction of CYP3A)
Croatian: Očekivano: ↔ doravirin ↓ takrolimus, sirolimus (indukcija CYP3A)
English: Uncommon aspartate aminotransferase increased, lipase increased, amylase increased, haemoglobin decreased
Croatian: Pretrage često povišene vrijednosti alanin aminotransferaze manje često povišene vrijednosti aspartat aminotransferaze, povišene vrijednosti lipaze, povišene vrijednosti amilaze, snižene vrijednosti hemoglobina rijetko povišene vrijednosti kreatin fosfokinaze u krvi
English: Joint or muscle pain or muscle weakness may also occur.
Croatian: Mogu se javiti i bol u zglobovima ili mišićima te mišićna slabost.
English: Rare dermatitis allergic, rosacea, angioedema* Musculoskeletal and connective tissue disorders Common muscle disorders*
Croatian: Poremećaji kože i potkožnog tkiva često alopecija*, osip manje često pruritus rijetko alergijski dermatitis, rozaceja, angioedem* Poremećaji mišićno-koštanog sustava i vezivnog tkiva često mišićni poremećaji*
English: Recommendation Concerning Co-administration with doravirine/lamivudine/tenofo vir disoproxil dasabuvir
Croatian: Preporuka za istodobnu primjenu s doravirinom/ lamivudinom/ tenofovirdizoproksilom dasabuvir
English: If co-administration cannot be avoided, a 100 mg dose of doravirine should be taken daily, approximately 12 h after the dose of doravirine/lamivudine/tenofovir disoproxil.
Croatian: Ako se istodobna primjena ne može izbjeći, treba uzimati dozu doravirina od 100 mg na dan, približno 12 sati nakon doze doravirina/ lamivudina/tenofovirdizoproksila.
English: Doravirine steady state pharmacokinetics following administration of 100 mg once daily to HIV-1 infected subjects, based on a population pharmacokinetics analysis are provided below.
Croatian: U nastavku se navode podaci temeljeni na populacijskoj farmakokinetičkoj analizi farmakokinetike doravirina u stanju dinamičke ravnoteže nakon primjene doze od 100 mg jedanput na dan u ispitanika s HIV-1 infekcijom,.
English:  R-methadone AUC 0.95 (0.90, 1.01) Cmax 0.98 (0.93, 1.03) C24 0.95 (0.88, 1.03)
Croatian: ↔ R-metadon AUC 0,95 (0,90; 1,01) Cmax 0,98 (0,93; 1,03) C24 0,95 (0,88; 1,03)
English: Each film-coated tablet contains 100 mg of doravirine, 300 mg of lamivudine and 245 mg of tenofovir disoproxil.
Croatian: Jedna filmom obložena tableta sadrži 100 mg doravirina, 300 mg lamivudina i 245 mg tenofovirdizoproksila.
English: Although the effect of supplementation with calcium and Vitamin D was not studied, such supplementation may be beneficial in all patients.
Croatian: D nije ispitivao, takvi bi nadomjesci mogli biti korisni svim bolesnicima.
English: • kidney damage, kidney stones, kidney failure, damage to kidney tubule cells, kidney injury,
Croatian: • oštećenje bubrega, bubrežni kamenci, zatajenje bubrega, oštećenje bubrežnih kanalića, ozljeda bubrega, izmokravanje velikih količina tekućine i osjećaj žeđi
English: Patients receiving doravirine/lamivudine/tenofovir disoproxil concomitantly with ledipasvir/sofosbuvir should be monitored for adverse reactions associated with tenofovir disoproxil.
Croatian: Potrebno je pratiti bolesnike koji primaju doravirin/lamivudin/ tenofovirdizoproksil istodobno s ledipasvirom/sofosbuvirom zbog mogućih nuspojava povezanih s tenofovirdizoproksilom.
English: Bone mineral density
Croatian: Mineralna gustoća kosti
English: HIV Antiviral Agents tenofovir disoproxil (300 mg QD, doravirine 100 mg SD)
Croatian: Antivirotici za liječenje HIV infekcije tenofovirdizoproksil (300 mg QD, doravirin 100 mg SD)
English: Respiratory, thoracic and mediastinal disorders Common cough*, nasal symptoms*
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja često kašalj*, nosni simptomi*
English: Geometric Mean Ratio (90 % CI)*
Croatian: Učinci na geometrijsku srednju vrijednost omjera koncentracija lijeka (90% CI)*
English: Each film-coated tablet contains 100 mg of doravirine, 300 mg of lamivudine, and 300 mg of tenofovir disoproxil fumarate equivalent to 245 mg of tenofovir disoproxil.
Croatian: Jedna filmom obložena tableta sadrži 100 mg doravirina, 300 mg lamivudina i 300 mg tenofovirdizoproksilfumarata, što odgovara 245 mg tenofovirdizoproksila.
English: Uncommon constipation, abdominal discomfort
Croatian: flatulencija manje često konstipacija, nelagoda u abdomenu
English: Severe acute exacerbations of hepatitis B (e.g., liver decompensated and liver failure) have been reported in patients who are co-infected with HIV-1 and HBV, and have discontinued lamivudine or tenofovir disoproxil, two of the components of Delstrigo.
Croatian: U bolesnika s istodobnom infekcijom virusom HIV-1 i HBV-om koji su prekinuli primjenu lamivudina ili tenofovirdizoproksila, dviju sastavnica lijeka Delstrigo, prijavljene su teške akutne egzacerbacije hepatitisa B (npr. dekompenzacija jetre i zatajenje jetre).
English: In clinical trials in HIV-1 infected adults, tenofovir disoproxil was associated with slightly greater decreases in bone mineral density (BMD) and increases in biochemical markers of bone metabolism, suggesting increased bone turnover relative to comparators.
Croatian: Bone mineral density, BMD) i povećanjima vrijednosti biokemijskih markera koštanog metabolizma, što ukazuje na pojačanu koštanu pregradnju u odnosu na usporedne lijekove.
English: How to store Delstrigo
Croatian: Kako čuvati Delstrigo
English: Expected:  canagliflozin  liraglutide  sitagliptin
Croatian: Očekivano: ↔ kanagliflozin ↔ liraglutid ↔ sitagliptin
English: Multiple dose rifampicin (600 mg QD, doravirine 100 mg SD)
Croatian: višestruke doze rifampicina (600 mg QD, doravirin 100 mg SD)
English: Vascular disorders Uncommon hypertension
Croatian: Krvožilni poremećaji manje često hipertenzija
English: Consider more frequent monitoring of HIV-1 viral load when chronic co-administration cannot be avoided.
Croatian: Kada se dugotrajna istodobna primjena ne može izbjeći, potrebno je razmotriti češće praćenje virusnog opterećenja HIV-1.