FrancophonIA/ELRC3.0 huggingface dataset:
English: Following an oral dose, the apparent terminal elimination half-life is approximately 6.5 hours.
Slovenian: Po peroralnem odmerku je navidezni končni razpolovni čas izločanja približno 6,5 ur.
English: If no adequate strength of Vokanamet is available, individual monocomponents should be used instead of the fixed dose combination.
Slovenian: Če ni na voljo ustrezna jakost zdravila Vokanamet, je treba namesto fiksne kombinacije uporabiti posamične monokomponente.
English: • if you have a severe infection
Slovenian: • če prebolevate hudo okužbo
English: Metformin is excreted into human breast milk in small amounts.
Slovenian: Metformin se izloča v materino mleko v majhnih količinah.
English: • if you are on medicines to lower your blood pressure (anti-hypertensives) or have ever had low blood pressure (hypotension).
Slovenian: • če jemljete zdravila za zniževanje krvnega tlaka (antihipertenzive) in ste imeli že kdaj znižan krvni tlak (hipotenzijo).
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking or continuing to take this medicine.
Slovenian: Nosečnost in dojenje Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo ali preden nadaljujete z jemanjem tega zdravila.
English: The safety and efficacy of Vokanamet in children under 18 years of age have not been established.
Slovenian: Varnost in učinkovitost zdravila Vokanamet pri otrocih, mlajših od 18 let, še nista bili dokazani.
English: • medicines which increase urine production (diuretics)
Slovenian: • zdravila, ki povečajo nastajanje urina (duiretiki)
English: If any of the above applies to you, talk to your doctor for further instructions.
Slovenian: Če kar koli od zgoraj navedenega velja za vas, se za neč navodil posvetujte z zdravnikom.
English: When this happens, sugar (glucose) builds up in the blood.
Slovenian: Če pride do tega, se koncentracija sladkorja (glukoze) v krvi zviša.
English: The effect of Vokanamet on fertility in humans has not been studied.
Slovenian: Vpliva zdravila Vokanamet na plodnost pri ljudeh niso preučevali.
English: This will lower your chance of having an upset stomach.
Slovenian: S tem boste zmanjšali možnost za draženje želodca.
English: Ketoacidosis is a condition in which substances called 'ketone bodies' accumulate in the blood and which can lead to diabetic pre-coma.
Slovenian: Ketoacidoza je stanje, pri katerem se snovi, imenovane 'ketonska telesa ' kopičijo v krvi, kar lahko povzroči diabetično predkomo.
English: • common: a metallic taste (taste disturbance)
Slovenian: • pogosti: kovinski okus (motnja okušanja)
English: A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital malformations.
Slovenian: Maloštevilni podatki o uporabi metformina pri nosečnicah ne kažejo na povečano tveganje za prirojene anomalije.
English: 211 patients from the clinical study in older patients participated in a body composition substudy using DXA body composition analysis.
Slovenian: 211 bolnikov iz klinične študije s starejšimi bolniki je sodelovalo v podskupini, v kateri so bolnikom analizirali sestavo telesa z metodo DEXA.
English: These changes are not likely to be clinically relevant.
Slovenian: Navedene spremembe po vsej verjetnosti niso klinično pomembne.
English: This is because this medicine can affect the way some other medicines work.
Slovenian: To zdravilo namreč lahko vpliva na delovanje nekaterih drugih zdravil, pa tudi nekatera druga zdravila lahko vplivajo na delovanje tega zdravila.
English: Side effects when taking metformin alone that were not described for canagliflozin:
Slovenian: Neželeni učinki pri jemanju samo metformina, ki jih niso opisovali pri jemanju kanagliflozina:
English: • Your doctor will prescribe the strength that is right for you.
Slovenian: • Zdravnik vam bo predpisal ustrezno jakost zdravila.
English: • if you have lost a lot of water from your body (dehydration), e.g. due to long-lasting or severe diarrhoea, or if you have vomited several times in a row
Slovenian: • če ste iz telesa izgubili veliko vode (ste dehidrirani) na primer zaradi dolgotrajne ali hude driske ali če ste večkrat zaporedoma bruhali
English: • certain medicines for the treatment of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists)
Slovenian: • nekatera zdravila za zdravljenje visokega krvnega tlaka (zaviralci ACE in antagonisti receptorjev angiotenzina II)
English: Lactic acidosis is a medical emergency and must be treated in a hospital.
Slovenian: Laktacidoza je nujno zdravstveno stanje in jo je treba zdraviti v bolnišnici.
English: The maximum daily dose of metformin should preferably be divided into 2-3 daily doses.
Slovenian: Najbolje je, da se največji dnevni odmerek metformina je razdeli v 2 do 3 dnevne odmerke.
English: In addition, in such patients greater decreases in GFR were reported (see sections 4.2 and 4.8).
Slovenian: Poleg tega so pri teh bolnikih poročali tudi o večjem zmanjšanju GFR (glejte poglavji 4.2 in 4.8).
English: b Gastrointestinal symptoms such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite occur most frequently during initiation of therapy and resolve spontaneously in most cases.
Slovenian: b Gastrointestinalni simptomi, kot so navzea, bruhanje, diareja, bolečine v trebuhu in izguba apetita, se najpogosteje pojavljajo ob začetku zdravljenja in v večini primerov spontano izzvenijo.
English: The most effective method to remove lactate and metformin is haemodialysis.
Slovenian: Najbolj učinkovit način odstranjevanja laktata in metformina je hemodializa.
English: There was no notable change in heart rate.
Slovenian: Pri tem ni bilo opazne spremembe srčne frekvence.
English: The observed pharmacokinetic and pharmacodynamic responses were consistent with those found in adult subjects.
Slovenian: Farmakokinetični in farmakodinamični odgovori so bili skladni z odgovori, ki so jih opazili pri odraslih preiskovancih.
English: When starting or using such products in combination with Vokanamet, close monitoring of renal function is necessary.
Slovenian: Ob uvedbi ali uporabi teh zdravil v kombinaciji z zdravilom Vokanamet je potrebno skrbno spremljanje delovanja ledvic.
English: • Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis);
Slovenian: • Vse vrste akutne metabolične acidoze (kot sta laktacidoza, diabetična ketoacidoza).
English: However, as precautionary measures, consideration should be given to carefully monitoring patients with a higher risk for amputation events and counselling patients about the importance of routine preventative foot care and maintaining adequate hydration.
Slovenian: Upoštevati je treba varnostne ukrepe kot so skrbno spremljanje bolnikov z večjim tveganjem za amputacije ter podučitev bolnikov o pomembnosti rutinske nege stopal in vzdrževanju zadostne hidracije.
English: Some studies indicate that taking canagliflozin may have contributed to the risk of lower limb amputation (mainly toe amputations).
Slovenian: Nekatere študije kažejo, da lahko jemanje kanagliflozina prispeva k tveganju za amputacije spodnjih okončin (večinoma prstov na nogah).
English: • The strength of Vokanamet that you will take varies depending on your condition and the amount of canagliflozin and metformin needed to control your blood sugar.
Slovenian: • Jakost zdravila Vokanamet, ki ga boste jemali je odvisna od vaše bolezni in od tega, koliko kanagliflozina in metformina potrebujete za uravnavanje koncentracije sladkorja v krvi.
English: • if you have recently had a heart attack or have severe blood circulation problems, such as ‘shock' or breathing difficulties
Slovenian: • če ste pred nedavnim doživeli srčni infarkt ali če imate resne težave s krvnim obtokom, kot sta šok ali oteženo dihanje
English: The doctor may decide to temporarily or permanently stop the treatment with Vokanamet.
Slovenian: Zdravnik vam lahko začasno ali trajno ukine zdravljenje z zdravilom Vokanamet.
English: Other side effects when taking canagliflozin alone: Very common (may affect more than 1 in 10 people)
Slovenian: Drugi neželeni učinki pri jemanju samo kanagliflozina: Zelo pogosti (lahko se pojavijo pri več kot 1 od 10 bolnikov)
English: After an oral dose of metformin hydrochloride tablet, Cmax is reached in approximately 2.5 hours (Tmax).
Slovenian: Po peroralni aplikaciji tablete z metforminijevim kloridom je Cmax dosežen po približno 2,5 ure (Tmax).
English: • Severe renal failure (GFR < 30 mL/min) (see sections 4.2 and 4.4);
Slovenian: • Huda ledvična odpoved (GFR < 30 ml/min ) (glejte poglavji 4.2 in 4.4).
English: Most infections were mild to moderate with no increase in the occurrence of serious adverse reactions.
Slovenian: Večina okužb je bila blagih do zmernih, pogostnost resnih neželenih učinkov pri tem ni bila povečana.
English: Vokanamet should not be used during pregnancy.
Slovenian: Zdravila Vokanamet se ne sme uporabljati med nosečnostjo.
English: Vokanamet should be taken orally twice daily with meals to reduce the gastrointestinal undesirable effects associated with metformin.
Slovenian: Zdravilo Vokanamet je treba jemati peroralno dvakrat na dan, z obrokom, da se zmanjša z metforminom povezane gastrointestinalne neželene učinke.
English: • Hepatic impairment, acute alcohol intoxication, alcoholism (see sections 4.2 and 4.5).
Slovenian: • Okvara jeter, akutna zastrupitev z alkoholom, alkoholizem (glejte poglavji 4.2 in 4.5).
English: You may already be taking one or more of these to treat your type 2 diabetes.
Slovenian: Morda za zdravljenje sladkorne bolezni tipa 2 že jemljete eno ali več navedenih zdravil.
English: The patient should be informed and more frequent blood glucose monitoring performed, especially at the beginning of treatment with such medicinal products.
Slovenian: Bolnik mora biti o tem poučen, koncentracijo glukoze v krvi pa je treba meriti pogosteje, še posebej na začetku zdravljenja s temi zdravili.
English: You may need more frequent blood glucose and kidney function tests, or your doctor may need to adjust the dosage of Vokanamet.
Slovenian: Morda boste morali pogosteje opravljati preiskave glukoze v krvi in delovanje ledvic, zdravnik pa bo morda moral prilagoditi odmerek zdravila Vokanamet.
English: The blood peak is lower than the plasma peak and appears at approximately the same time.
Slovenian: Največja koncentracija v krvi je manjša od največje koncentracije v plazmi, nastopi pa ob približno istem času.
English: • It is important to check your feet regularly and adhere to any other advice regarding foot care and adequate hydration given by your health care professional.
Slovenian: • Pomembno je, da si redno pregledujete stopala in upoštevate nasvete zdravstvenih delavcev o negi stopal in vzdrževanju zadostne količine telesnih tekočin (hidracije).
English: If you stop taking Vokanamet
Slovenian: Če ste prenehali jemati zdravilo Vokanamet
English: What Vokanamet is and what it is used for What you need to know before you take Vokanamet How to take Vokanamet
Slovenian: Kaj je zdravilo Vokanamet in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Vokanamet Kako jemati zdravilo Vokanamet
English: Canagliflozin/Metformin
Slovenian: Kanagliflozin/Metformin
English: • if you have severely reduced kidney function
Slovenian: • če imate hudo oslabljeno delovanje ledvic
English: Frequency categories are based on information available from the metformin Summary of Product Characteristics.
Slovenian: Razporeditev po kategorijah pogostnosti temelji na podatkih, ki so navedeni v Povzetku glavnih značilnosti zdravila za metformin.
English: • cimetidine (medicine used to treat stomach problems)
Slovenian: • cimetidin (za zdravljenje želodčnih težav)
English: Vokanamet has not been studied in patients with type 1 diabetes and is therefore not recommended for use in these patients.
Slovenian: Zdravila Vokanamet niso preučevali pri bolnikih s sladkorno boleznijo tipa 1, zato uporaba pri teh bolnikih ni priporočljiva.
English: Maximum daily dose is 2000 mg The starting dose is at most half of the maximum dose.
Slovenian: Največji dnevni odmerek je 2.000 mg Začetni odmerek je največ polovica največjega odmerka.
English: Diagnostic laboratory findings are decreased blood pH (< 7.35), increased plasma lactate levels (> 5 mmol/L) and an increased anion gap and lactate/pyruvate ratio.
Slovenian: Diagnostični laboratorijski izvidi so zmanjšan pH krvi (< 7,35), znišane ravni laktata v plazmi (> 5 mmol/l) in povečana anionska vrzel ter razmerje laktat/piruvat.
English: Vokanamet has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Vokanamet nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: These symptoms could be a sign of “diabetic ketoacidosis” - a rare but serious, sometimes life-threatening problem you can get with diabetes because of increased levels of “ketone bodies” in your urine or blood, seen in tests.
Slovenian: Ti simptomi so lahko znaki “diabetične ketoacidoze” - redke, a resne, včasih življenjsko ogrožajoče motnje, ki se lahko pojavi pri sladkorni bolezni zaradi povečane koncentracije “ketonskih teles” v urinu in krvi, kar pokažejo laboratorijske preiskave.
English: In in vitro studies, canagliflozin neither inhibited cytochrome P450 CYP1A2, CYP2A6, CYP2C19, CYP2D6, or CYP2E1, CYP2B6, CYP2C8, CYP2C9, nor induced CYP1A2, CYP2C19, CYP2B6, CYP3A4 at higher than therapeutic concentrations.
Slovenian: V in vitro študijah kanagliflozin pri odmerkih, višjih od terapevtskih, ni niti zaviral izoencimov citokroma P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, ali CYP2E1, CYP2B6, CYP2C8, CYP2C9, niti induciral CYP1A2, CYP2C19, CYP2B6, CYP3A4.
English: As Vokanamet contains metformin, Vokanamet must be discontinued at the time of surgery under general, spinal, or epidural anaesthesia.
Slovenian: Zdravilo Vokanamet vsebuje metformin, zato je treba zdravljenje z njim prekiniti v času kirurškega posega pod splošno, spinalno ali epiduralno anestezijo.
English: • in patients already being treated with the combination of canagliflozin and metformin as separate tablets.
Slovenian: • pri bolnikih, ki se že zdravijo s kombinacijo kanagliflozina in metformina v ločenih tabletah.
English: Table 5: Efficacy results from active-controlled clinical studiesa
Slovenian: Preglednica 5: Rezultati učinkovitosti iz kliničnih študij nadzorovanih z učinkovino
English: The pack sizes are cartons of 20, 60, and 180 tablets (3 bottles containing 60 tablets each).
Slovenian: Velikosti pakiranj so škatle z 20, 60 in 180 (3 plastenke, vsaka s 60 tabletami) tabletami.
English: • if you have liver problems
Slovenian: • če imate težave z jetri
English: Renal function GFR should be assessed before treatment initiation and regularly thereafter (see section 4.2).
Slovenian: Delovanje ledvic GFR je treba oceniti pred uvedbo zdravljenja, nato pa v rednih presledkih (glejte poglavje 4.2).
English: In controlled clinical trials, Cmax did not exceed 5 μg/mL, even at maximum doses.
Slovenian: V nadzorovanih kliničnih študijah Cmax tudi pri najvišjih odmerkih ni presegal 5 µg/ml.
English: In the event of an overdose of Vokanamet, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute clinical measures as dictated by the patient's clinical status.
Slovenian: V primeru prevelikega odmerjanja zdravila Vokanamet je smiselno začeti z običajnimi podpornimi ukrepi, kot so odstranjevanje neabsorbiranega zdravila iz prebavil, klinično spremljanje bolnika in uvedba kliničnih ukrepov skladno z bolnikovo klinično sliko.
English: • Acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure,
Slovenian: • Akutna ali kronična bolezen, ki lahko povzroča tkivno hipoksijo, kot so srčno popuščanje,
English: • efavirenz or ritonavir (medicines used to treat HIV infection)
Slovenian: • efavirenz ali ritonavir (zdravili, ki ju uporabljamo pri okužbi z virusom HIV)
English: Adverse reactions in table 1 are based on the pooled analysis of the four 26-week placebo-controlled studies (n = 2,313) described above.
Slovenian: Podatki o neželenih učinkih v preglednici 1 izhajajo iz zgoraj opisane analize združenih podatkov štirih 26-tedenskih s placebom nadzorovanih študij (n = 2.313).
English: When pregnancy is detected, treatment with Vokanamet should be discontinued.
Slovenian: V primeru nosečnosti je treba zdravljenje z zdravilom Vokanamet prekiniti.
English: Stop taking Vokanamet for a short time if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal.
Slovenian: Za kratek čas prenehajte jemati zdravilo Vokanamet, če imate stanje, ki je lahko povezano z dehidracijo (znatna izguba telesnih tekočin), kot je hudo bruhanje, driska, povišana telesna temperatura, izpostavljenost vročini ali, če pijete manj tekočine kot običajno.
English: The racial distribution of patients who received canagliflozin was 72% White, 16% Asian, 4% Black, and 8% other groups.
Slovenian: Med bolniki, ki so prejemali kanagliflozin, je bila pripadnost različnim rasam naslednja: 72% bolnikov je bilo bele rase, 16% azijske rase, 4% črne rase, 8% je bilo pripadnikov drugih etničnih skupin.
English: In case of suspected symptoms, the patient should stop taking Vokanamet and seek immediate medical attention.
Slovenian: Ob sumu na simptome mora bolnik prenehati z jemanjem zdravila Vokanamet in takoj poiskati zdravniško pomoč.
English: Lactic acidosis, a very rare but serious metabolic complication, most often occurs at acute worsening of renal function or cardiorespiratory illness or sepsis.
Slovenian: Laktacidoza, zelo redek, a resen presnovni zaplet , se najpogosteje pojavi ob akutnem poslabšanju delovanja ledvic, ob kardiorespiratorni bolezni ali sepsi.
English: • If your doctor has prescribed this medicine along with any medicine for lowering cholesterol such as cholestyramine you should take this medicine at least 1 hour before or 4 hours to
Slovenian: • Če vam je zdravnik predpisal to zdravilo skupaj z zdravilom za zmanjševanje koncentracije holesterola, kot je holestiramin, morate vzeti to zdravilo vsaj 1 uro prej ali 4 do 6 ur po tem, ko ste vzeli zdravilo za zmanjševanje koncentracije holesterola.
English: Pharmacodynamic effects of canagliflozin
Slovenian: Farmakodinamični učinki kanagliflozina
English: Lower limb amputations
Slovenian: Amputacije spodnjih okončin
English: Children and adolescents Vokanamet is not recommended for children and adolescents under 18 years.
Slovenian: Otroci in mladostniki Pri otrocih in mladostnikih, ki so stari manj kot 18 let, uporaba zdravila Vokanamet ni priporočljiva.
English: To assess risk factors for these adverse reactions, a larger pooled analysis (N = 9,439) of patients from eight controlled phase 3 studies including both doses of canagliflozin was conducted.
Slovenian: Za oceno dejavnikov tveganja za navedene neželene učinke so izvedli večjo analizo združenih podatkov bolnikov (n = 9.439) iz osmih nadzorovanih študij faze III z obema odmerkoma kanagliflozina.
English: Patients with baseline HbA1c > 10% to ≤ 12%
Slovenian: Bolniki z izhodiščno ravnijo HbA1c od > 10% do ≤ 12%
English: Analysis of the results for overweight patients treated with metformin after failure of diet alone showed:
Slovenian: Za bolnike s prekomerno telesno maso, ki so bili zdravljeni z metforminom po neuspešnem zdravljenju samo z dieto, je analiza rezultatov pokazala:
English: Canagliflozin, one of the ingredients in Vokanamet, should not be used during pregnancy.
Slovenian: Kanagliflozina, ki je ena od sestavin zdravila Vokanamet, ne smete jemati med nosečnostjo.
English: Other medicines and Vokanamet
Slovenian: Druga zdravila in zdravilo Vokanamet
English: In patients where DKA is suspected or diagnosed, treatment with Vokanamet should be discontinued immediately.
Slovenian: Pri bolnikih, pri katerih obstaja sum na DKA ali že imajo diagnozo DKA, je treba zdravljenje z zdravilom Vokanamet takoj prekiniti.
English: If you are already taking both canagliflozin and metformin as single tablets, Vokanamet can replace them in one tablet.
Slovenian: Če kanagliflozin in metformin že jemljete v obliki ločenih tablet, jih lahko zdravilo Vokanamet lahko nadomesti v obliki ene tablete.
English: Patients had an overall mean age of 59.6 years (range 21 years to 96 years), with 3,082 patients ≥ 65 years of age and 510 patients ≥ 75 years of age.
Slovenian: Povprečna starost vseh bolnikov je bila 59,6 let (od 21 do 96 let), pri čemer je bilo 3.082 bolnikov starih najmanj
English: Food decreases the extent and slightly delays the absorption of metformin.
Slovenian: Hrana nekoliko upočasni absorpcijo metformina in zmanjša njen obseg.
English: • very common: feeling sick (nausea), being sick (vomiting), diarrhoea, stomach ache, and loss of appetite
Slovenian: • zelo pogosti: siljenje na bruhanje (navzea), bruhanje, driska, bolečine v trebuhu in izguba apetita
English: A pre-specified interim meta-analysis was conducted of adjudicated major cardiovascular events in the phase 2 and 3 clinical studies in 9,632 patients with type 2 diabetes, including 4,327 patients (44.9%) with cardiovascular disease or at high risk for cardiovascular disease who are participating in an ongoing cardiovascular study.
Slovenian: Vnaprej dogovorjeno vmesno metaanalizo domnevnih večjih kardiovaskularnih dogodkov so izvedli na podatkih 9.632 bolnikov s sladkorno boleznijo tipa 2 iz kliničnih študij faze II in III, med katerimi je tudi 4.327 bolnikov (44,9%), ki imajo katero od kardiovaskularnih bolezni ali pa povečano tveganje za kardiovaskularne bolezni in so vključeni v kardiovaskularno študijo, ki še poteka.
English: Patients tolerating canagliflozin can continue use at a maximum total daily dose of 100 mg.
Slovenian: Bolniki, ki prenašajo kanagliflozin, lahko nadaljujejo z jemanjem največjega skupnega dnevnega odmerka 100 mg.
English: In patients susceptible to greater reductions in intravascular volume as described above, larger decreases in GFR (> 30%) were sometimes seen, which subsequently improved, and infrequently required interruption of treatment with canagliflozin (see section 4.8).
Slovenian: Pri bolnikih, ki so nagnjeni k bolj obsežnemu zmanjšanju znotrajžilnega volumna, kot je opisano v prejšnjem odstavku, so včasih opazili tudi bolj obsežno zmanjšanje GFR (za > 30%), kar se je sčasoma popravilo, in le redko je bila potrebna prekinitev zdravljenja s kanagliflozinom (glejte poglavje 4.8).
English: PHARMACEUTICAL FORM AND CONTENTS 20 film-coated tablets
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 20 filmsko obloženih tablet
English: Inhibition of BCRP by canagliflozin cannot be excluded at an intestinal level and increased exposure may therefore occur for medicinal products transported by BCRP, e.g., certain statins like rosuvastatin and some anti-cancer medicinal products.
Slovenian: Zaviranja BCRP v črevesju s kanagliflozinom ni mogoče izključiti, zato lahko pride do povečane izpostavljenosti zdravilom, ki jih prenaša BCRP (npr. nekateri statini, kot je rosuvastatin, in nekatere učinkovine za zdravljenje rakavih bolezni).
English: Canagliflozin is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).
Slovenian: Kanagliflozin se prenaša vezan na P-glikoprotein (P-gp) in membranski transporterski protein (BCRP - Breast Cancer Resistance Protein).
English: Patients should be advised to report symptoms of volume depletion.
Slovenian: Bolnikom je treba naročiti, naj zdravniku povedo o pojavu simptomov hipovolemije.
English: In case of dehydration (severe diarrhoea or vomiting, fever or reduced fluid intake), Vokanamet should be temporarily discontinued and contact with a health care professional is recommended.
Slovenian: V primeru dehidracije (huda driska ali bruhanje, zvišana telesna temperatura ali zmanjšan vnos tekočine) je treba jemanje zdravila Vokanamet začasno prekiniti; priporoča se posvet z zdravstvenim delavcem.