FrancophonIA/ELRC3.0 huggingface dataset:
English: • medicines used to treat bacterial infections (telithromycin, rifampicin and ciprofloxacin)
Slovenian: • zdravila za zdravljenje bakterijskih okužb (telitromicin, rifampicin in ciprofloksacin),
English: Treatment of secondary hyperparathyroidism (HPT) in patients with end-stage renal disease (ESRD) on maintenance dialysis therapy.
Slovenian: Zdravljenje sekundarnega hiperparatiroidizma (HPT) pri bolnikih s končno odpovedjo ledvic (ESRD) na vzdrževalnem dializnem zdravljenju.
English: Once maintenance dose levels have been established, serum calcium should be measured every 2 to 3 months.
Slovenian: Ko je vzdrževalni odmerek določen, je treba kalcij v serumu meriti na 2 do 3 mesece.
English: After absorption, cinacalcet concentrations decline in a biphasic fashion with an initial half-life of approximately 6 hours and a terminal half-life of 30 to 40 hours.
Slovenian: Po absorpciji je upadanje koncentracije cinakalceta dvofazno, z uvodnim razpolovnim časom približno 6 ur in končnim razpolovnim časom od 30 do 40 ur.
English: Manifestations of hypocalcaemia may include paraesthesias, myalgias, cramping, tetany and convulsions.
Slovenian: Med znaki hipokalciemije so lahko parestezije, mialgije, krči, tetanija in konvulzije.
English: • liver problems;
Slovenian: • težave z jetri;
English: Since cinacalcet is highly protein-bound, haemodialysis is not an effective treatment for overdose.
Slovenian: Cinakalcet je močno vezan na beljakovine, zato hemodializa za zdravljenje prevelikega odmerka ni učinkovita.
English: The non-teratogenic dose in rats was 4.4 times, on an AUC basis, the maximum dose for secondary HPT.
Slovenian: Neteratogeni odmerek pri podganah je bil (na podlagi AUC) 4,4-krat tolikšen kot največji odmerek za sekundarni hiperparatiroidizem.
English: Secondary hyperparathyroidism, parathyroid carcinoma and primary hyperparathyroidism Based on available data from patients receiving cinacalcet in placebo controlled studies and single-arm studies the most commonly reported adverse reactions were nausea and vomiting.
Slovenian: Sekundarni hiperparatiroidizem, paratiroidni karcinom in primarni hiperparatiroidizem Na osnovi razpoložljivih podatkov o bolnikih, ki so cinakalcet prejemali v študijah, nadzorovanih s placebom, in študijah z enim krakom, sta bila najpogosteje poročana neželena učinka navzea in bruhanje.
English: Cataracts and lens opacities were observed in the repeat dose rodent toxicology and carcinogenicity studies, but were not observed in dogs or monkeys or in clinical studies where cataract formation was monitored.
Slovenian: V študijah toksičnosti pri ponavljajočih se odmerkih in študijah kancerogenega potenciala pri glodalcih so ugotavljali katarakte in motnjave leč; takšnih sprememb niso ugotovili pri psih in opicah in tudi ne v kliničnih študijah, v katerih so spremljali nastajanje katarakt.
English: • a medicine used to treat HIV infection and AIDS (ritonavir)
Slovenian: • zdravilo za zdravljenje okužbe s HIV in AIDS-a (ritonavir),
English: What Cinacalcet Mylan is and what it is used for
Slovenian: Kaj je zdravilo Cinakalcet Mylan in za kaj ga uporabljamo
English: Cinacalcet decreased iPTH and Ca x P, calcium and phosphorus levels regardless of baseline iPTH or Ca x P level, dialysis modality (PD versus HD), duration of dialysis, and whether or not vitamin D sterols were administered.
Slovenian: Cinakalcet je znižal ravni iPTH, Ca x P, kalcij in fosfor ne glede na izhodiščno raven iPTH ali Ca x P, način dialize (peritonealna dializa ali hemodializa), trajanje dialize in uporabo ali neuporabo sterolov vitamina D.
English: After titration to the maximum dose of cinacalcet, serum calcium should be periodically monitored; if clinically relevant reductions in serum calcium are not maintained, discontinuation of cinacalcet therapy should be considered (see section 5.1).
Slovenian: Po titriranju do največjega odmerka cinakalceta kalcij v serumu redno kontrolirajte; če zdravilo ne ohranja klinično pomembnega znižanja kalcija v serumu, pride v poštev prenehanje zdravljenja s cinakalcetom (glejte poglavje 5.1).
English: What you need to know before you take Cinacalcet Mylan
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Cinakalcet Mylan
English: Cinacalcet was initiated at a dose of 30 mg twice daily and titrated to maintain a corrected total serum calcium concentration within the normal range.
Slovenian: Cinakalcet so jim uvedli v odmerku 30 mg dvakrat na dan, nato pa so odmerek prilagajali, da so vzdrževali korigirano celotno koncentracijo kalcija v normalnem območju.
English: In Chronic Kidney Disease (CKD) patients receiving dialysis who were administered cinacalcet, approximately 30% of patients had at least one serum calcium value less than 7.5 mg/dl (1.9 mmol/l).
Slovenian: Pri bolnikih s kronično boleznijo ledvic, ki so se zdravili z dializo in so prejemali cinakalcet, je imelo približno 30 % bolnikov vsaj eno vrednost kalcija v serumu manj kot 7,5 mg/dl (1,9 mmol/l).
English: The parathyroids are four small glands in the neck, near the thyroid gland, that produce parathyroid hormone (PTH).
Slovenian: Obščitnice so štiri majhne žleze, ki ležijo v vratu blizu žleze ščitnice in izločajo paratiroidni hormon (PTH).
English: Cinacalcet Mylan reduces calcium levels.
Slovenian: Zdravilo Cinakalcet Mylan znižuje koncentracije kalcija.
English: EVOLVE (EValuation Of Cinacalcet Therapy to Lower CardioVascular Events) was a randomised, double-blind clinical study evaluating cinacalcet versus placebo for the reduction of the risk of allcause mortality and cardiovascular events in 3,883 patients with secondary HPT and CKD receiving dialysis.
Slovenian: Študija EVOLVE (EValuation Of Cinacalcet Therapy to Lower CardioVascular Events) je bila randomizirana, dvojno slepa klinična študija, v kateri so ocenjevali cinakalcet v primerjavi s placebom za zmanjšanje tveganja za umrljivost zaradi vseh vzrokov in za kardiovaskularne dogodke pri 3.883 bolnikih s sekundarnim hiperparatiroidizmom in kronično boleznijo ledvic, ki so na dializi.
English: Cinacalcet Mylan contains the active ingredient cinacalcet, which works by controlling the levels of parathyroid hormone (PTH), calcium and phosphorous in your body.
Slovenian: Zdravilo Cinakalcet Mylan vsebuja zdravilno učinkovino cinakalcet, ki deluje tako, da v telesu uravnava koncentracijo paratiroidnega hormona (PTH), kalcija in fosforja.
English: Compared to subjects with normal liver function, average AUC of cinacalcet was approximately 2-fold higher in subjects with moderate impairment and approximately 4-fold higher in subjects with severe impairment.
Slovenian: V primerjavi s preiskovanci z normalnim delovanjem jeter je povprečna AUC cinakalceta pri preiskovancih z zmerno okvaro približno 2-krat večja, pri preiskovancih s hudo okvaro pa približno 4-krat večja.
English: Cinacalcet is a calcimimetic agent which directly lowers PTH levels by increasing the sensitivity of the calcium sensing receptor to extracellular calcium.
Slovenian: Cinakalcet je kalcimimetično zdravilo, ki neposredno zniža koncentracijo PTH tako, da poveča občutljivost teh receptorjev na zunajcelični kalcij.
English: Cinacalcet is excreted in the milk of lactating rats with a high milk to plasma ratio.
Slovenian: V mleko doječih podgan se cinakalcet izloča z velikim razmerjem med mlekom in plazmo.
English: The tablet coating contains hypromellose, titanium dioxide (E171), triacetin, indigo carmine (E132), iron oxide yellow (E172).
Slovenian: Filmska obloga vsebuje: hipromelozo, titanov dioksid (E171), triacetin, indigotin (E132) in rumeni železov oksid (E172).
English: Cataracts are known to occur in rodents as a result of hypocalcaemia.
Slovenian: Znano je, da se pri glodalcih zaradi hipokalciemije pojavijo katarakte.
English: • a medicine used to treat depression (fluvoxamine).
Slovenian: • zdravilo za zdravljenje depresije (fluvoksamin).
English: Sevelamer: Co-administration of sevelamer (2,400 mg, three times a day) did not affect the pharmacokinetics of cinacalcet.
Slovenian: Sevelamer: Sočasna uporaba sevelamera (2400 mg trikrat na dan) ni vplivala na farmakokinetiko cinakalceta.
English: Do not use this medicine after the expiry date which is stated on the blister, carton or bottle after EXP.
Slovenian: Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu, škatli ali plastenki poleg oznake EXP. Rok uporabnosti se izteče na zadnji dan navedenega meseca.
English: In the event that corrected serum calcium levels fall below 8.4 mg/dl (2.1 mmol/l) and/or symptoms of hypocalcaemia occur the following management is recommended:
Slovenian: V primeru, da se koncentracija korigiranega kalcija v serumu zniža pod 8,4 mg/dl (2,1 mmol/l) in/ali se pojavijo simptomi hipokalciemije, je priporočljivo sledeče ukrepanje:
English: In vitro data indicate that cinacalcet is in part metabolised by CYP1A2.
Slovenian: Podatki in vitro kažejo, da se cinakalcet deloma presnavlja s CYP1A2.
English: Once the maintenance dose has been established, serum calcium should be measured approximately monthly.
Slovenian: Ko je vzdrževalni odmerek določen, je treba koncentracijo kalcija v serumu izmeriti približno enkrat na mesec.
English: • low calcium levels in the blood (hypocalcaemia).
Slovenian: • nizke vrednosti kalcija v krvi (hipokalciemija).
English: The active substance is cinacalcet.
Slovenian: Zdravilna učinkovina je cinakalcet.
English: Cinacalcet Mylan with food and drink Cinacalcet Mylan should be taken with or shortly after food.
Slovenian: Zdravilo Cinakalcet Mylan skupaj s hrano in pijačo Zdravilo Cinakalcet Mylan morate vzeti skupaj s hrano ali kmalu po jedi.
English: • If you experience swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing (angioedema).
Slovenian: • če se vam pojavi oteklost obraza, ustnic, ust, jezika ali žrela, ki lahko povzroči težave s požiranjem ali dihanjem (angioedem).
English: It is not known whether cinacalcet is excreted in human milk.
Slovenian: Ni znano, ali se cinakalcet pri človeku izloča v materino mleko.
English: In a clinical study of ESRD patients on dialysis, free testosterone levels decreased by a median of 31.3% in the cinacalcet-treated patients and by 16.3% in the placebo-treated patients after 6 months of treatment.
Slovenian: V klinični študiji bolnikov s končno odpovedjo ledvic na dializi se je koncentracija prostega testosterona po 6 mesecih zdravljenja s cinakalcetom znižala za mediano 31,3 %, po 6 mesecih uporabe placeba pa za mediano 16,3 %.
English: Description of selected adverse reactions
Slovenian: c) Opis izbranih neželenih učinkov
English: The tablets must be taken whole and are not to be chewed, crushed or divided.
Slovenian: Tablete morate vzeti cele in jih ne smete zgristi, zdrobiti ali lomiti.
English: Renal excretion of metabolites was the prevalent route of elimination of radioactivity.
Slovenian: Glavna pot izločanja radioaktivnosti je bilo izločanje presnovkov skozi ledvice.
English: These may be signs that your calcium levels are too low (hypocalcaemia).
Slovenian: To so lahko znaki prenizke koncentracije kalcija (hipokalciemija).
English: Patients receiving cinacalcet should not be given etelcalcetide.
Slovenian: Bolniki, ki prejemajo cinakalcet, ne smejo dobiti etelkalcetida.
English: The dose of cinacalcet should be titrated every 2 to 4 weeks through sequential doses of 30 mg twice daily, 60 mg twice daily, 90 mg twice daily, and 90 mg three or four times daily as necessary to reduce serum calcium concentration to or below the upper limit of normal.
Slovenian: Priporočeni začetni odmerek zdravila Cinakalcet Mylan za odrasle je 30 mg dvakrat na dan. Odmerjanje cinakalceta je treba titrirati na 2 do 4 tedne z zaporednimi odmerki 30 mg dvakrat na dan, 60 mg dvakrat na dan, 90 mg dvakrat na dan in 90 mg trikrat ali štirikrat na dan, kot je potrebno za znižanje koncentracije kalcija v serumu na zgornjo mejo normalnega območja ali pod njo.
English: Your doctor will discuss with you if you should discontinue either breast-feeding or treatment with Cinacalcet Mylan.
Slovenian: Zdravnik se bo pogovoril z vami o prenehanju bodisi dojenja bodisi zdravljenja z zdravilom Cinakalcet Mylan.
English: Children under the age of 18 must not take Cinacalcet Mylan.
Slovenian: Otroci in mladostniki Zdravila Cinakalcet Mylan ne smejo jemati otroci, mlajši od 18 let.
English: • medicines used to treat skin and fungal infections (ketoconazole, itraconazole and voriconazole)
Slovenian: • zdravila za zdravljenje kožnih in glivičnih okužb (ketokonazol, itrakonazol in vorikonazol),
English: QT prolongation and ventricular arrhythmia secondary to hypocalcaemia QT prolongation and ventricular arrhythmia secondary to hypocalcaemia have been identified during post-marketing use of cinacalcet, the frequencies of which cannot be estimated from available data (see section 4.4).
Slovenian: Podaljšanje intervala QT in ventrikularna aritmija zaradi hipokalciemije Med uporabo cinakalceta v obdobju trženja zdravila sta bili ugotovljeni podaljšanje intervala QT in ventrikularna aritmija zaradi hipokalciemije; njihove pogostnosti iz razpoložljivih podatkov ni mogoče oceniti (glejte poglavje 4.4).
English: The pharmacokinetics of cinacalcet was studied in paediatric patients with ESRD receiving dialysis aged 3 to 17 years of age.
Slovenian: Farmakokinetiko cinakalceta so raziskali pri pediatričnih bolnikih s končno odpovedjo ledvic, zdravljenih z dializo, starih od 3 do 17 let.
English: Tell your doctor if you experience an unusually fast or pounding heartbeat, if you have heart rhythm problems, or if you take medicines known to cause heart rhythm problems, while taking Cinacalcet Mylan.
Slovenian: Medtem ko jemljete zdravilo Cinakalcet Mylan, morate zdravniku povedati, če opazite nenavadno hiter ali razbijajoč srčni utrip, če imate težave s srčnim ritmom, ali če jemljete zdravila, za katera je znano, da povzročajo težave s srčnim ritmom.
English: ≤ 7.5 mg/dL (1.9 mmol/L) or persistent symptoms of hypocalcaemia and vitamin D cannot be increased
Slovenian: ≤ 7,5 mg/dl (1,9 mmol/l) ali persistentni simptomi hipokalciemije, vitamina D pa ni mogoče zvišati
English: Cinacalcet Mylan is not indicated for use in paediatric patients.
Slovenian: Zdravilo Cinakalcet Mylan ni indicirano za uporabo pri pediatričnih bolnikih.
English: Co-administration of 200 mg, twice daily ketoconazole, a strong inhibitor of CYP3A4, caused an approximate 2-fold increase in cinacalcet levels.
Slovenian: Sočasna uporaba 200 mg ketokonazola (močnega zaviralca CYP3A4) dvakrat na dan je povzročila približno 2-kraten porast koncentracije cinakalceta.
English: Worsening heart failure* QT prolongation and ventricular arrhythmia secondary to hypocalcaemia*
Slovenian: Srčne bolezni poslabšanje srčnega popuščanja* podaljšanje intervala QT in ventrikularna aritmija zaradi hipokalciemije*
English: • breathing difficulties (dyspnoea)
Slovenian: • težave z dihanjem (dispneja),
English: PTH should be measured 1 to 4 weeks after initiation or dose adjustment of cinacalcet.
Slovenian: PTH je treba izmeriti od 1 do 4 tedne po začetku zdravljenja oz. prilagoditvi odmerka cinakalceta.
English: Dextromethorphan: Multiple doses of 50 mg cinacalcet increased the AUC of 30 mg dextromethorphan (metabolised primarily by CYP2D6) by 11-fold in CYP2D6 extensive metabolisers.
Slovenian: Dekstrometorfan: Večkratni odmerki 50 mg cinakalceta so pri izrazitih presnavljalcih s CYP2D6 povečali AUC 30 mg dekstrometorfana (ki se primarno presnavlja s CYP2D6) za 11-krat.
English: In a 28 week placebo-controlled study, 67 adult patients with primary HPT who met criteria for parathyroidectomy on the basis of corrected total serum calcium (> 11.3 mg/dl (2.82 mmol/l) but ≤ 12.5 mg/dl (3.12 mmol/l), but who were unable to undergo parathyroidectomy were included.
Slovenian: V 28-tedensko, s placebom nadzorovano študijo, je bilo vključenih 67 odraslih bolnikov s primarnim hiperparatiroidizmom, ki so izpolnjevali merila za paratiroidektomijo na podlagi korigiranega celotnega kalcija v serumu (> 11,3 mg/dl (2,82 mmol/l), toda ≤ 12,5 mg/dl (3,12 mmol/l), a jim ni bilo mogoče narediti paratiroidektomije.
English: Soon after dosing, PTH begins to decrease until a nadir at approximately 2 to 6 hours post dose, corresponding with cinacalcet Cmax.
Slovenian: Kmalu po uporabi zdravila začne koncentracija PTH upadati in doseže najnižjo točko približno 2 do 6 ur po odmerku, kar ustreza Cmax cinakalceta.
English: • to reduce high levels of calcium in the blood (hypercalcaemia) in patients with parathyroid cancer
Slovenian: • za zmanjšanje zvišane koncentracije kalcija v krvi (hiperkalciemije) pri bolnikih z rakom obščitnic,
English: • medicines used to treat changes in heart rate (flecainide and propafenone)
Slovenian: • zdravila za zdravljenje motenj srčnega ritma (flekainid in propafenon),
English: Mild hepatic impairment did not notably affect the pharmacokinetics of cinacalcet.
Slovenian: Blaga okvara jeter ni pomembneje vplivala na farmakokinetiko cinakalceta.
English: After steady state is reached, serum calcium concentrations remain constant over the dosing interval.
Slovenian: Ko je doseženo stanje dinamičnega ravnovesja, ostane koncentracija kalcija v serumu med odmernim intervalom stalna.
English: < 8.4 mg/dL (2.1 mmol/L) and > 7.5 mg/dL (1.9 mmol/L), or in the presence of clinical symptoms of hypocalcaemia
Slovenian: < 8,4 mg/dl (2,1 mmol/l) in > 7,5 mg/dl (1,9 mmol/l) ali prisotnost kliničnih simptomov hipokalciemije
English: How to store Cinacalcet Mylan Contents of the pack and other information
Slovenian: Shranjevanje zdravila Cinakalcet Mylan Vsebina pakiranja in dodatne informacije
English: If PTH levels decrease below the recommended target range in patients treated with cinacalcet, the dose of cinacalcet and/or vitamin D sterols should be reduced or therapy discontinued.
Slovenian: Če se pri bolnikih, zdravljenih s cinakalcetom, koncentracija PTH zniža pod priporočeno ciljno območje, zmanjšajte odmerek zdravila cinakalcet in/ali sterolov vitamina D ali prekinite terapijo.
English: • a medicine used to treat high blood pressure (metoprolol).
Slovenian: • zdravila za zdravljenje visokega krvnega tlaka (metoprolol).
English: Mean baseline iPTH concentrations across the 3 studies were 733 and 683 pg/ml (77.8 and 72.4 pmol/l) for the cinacalcet and placebo groups, respectively.
Slovenian: Povprečna izhodiščna koncentracija iPTH za vse 3 študije je bila v skupinah s cinakalcetom 733 pg/ml (77,8 pmol/l) in v skupinah s placebom 683 pg/ml (72,4 pmol/l).
English: A significantly higher percentage of cinacalcet treated patients achieved mean corrected total serum calcium concentration ≤ 10.3 mg/dl (2.57 mmol/l) and ≥ 1 mg/dl (0.25 mmol/l) decrease from baseline in mean corrected total serum calcium concentration, when compared with the placebo treated patients (75.8% versus 0% and 84.8% versus 5.9% respectively).
Slovenian: V primerjavi z bolniki, ki so prejemali placebo, je signifikatno večji delež bolnikov, ki so prejemali cinakalcet, dosegel povprečno korigirano celotno koncentracijo kalcija v serumu ≤ 10,3 mg/dl (2,57 mmol/l) in ≥ 1 mg/dl (0,25 mmol/l) znižanje od povprečne korigirane celotne koncentracije kalcija v serumu v primerjavi z izhodiščem (75,8 % v primerjavi z 0 % in 84,8 % v primerjavi s 5,9 %).
English: Since cinacalcet lowers serum calcium, patients should be monitored carefully for the occurrence of hypocalcaemia (see section 4.2).
Slovenian: Ker cinakalcet znižuje kalcij v serumu, je treba bolnike natančno nadzirati glede hipokalciemije (glejte poglavje 4.2).
English: “Primary” means that the hyperparathyroidism is not caused by any other condition and “secondary” means that the hyperparathyroidism is caused by another condition, e.g. kidney disease.
Slovenian: Pri primarnem in sekundarnem hiperparatiroidizmu obščitnične žleze izločajo preveč PTH. "Primarni" pomeni, da hiperparatiroidizma ne povzroča kakšna druga bolezen, "sekundarni" pa pomeni, da ga povzroča neka druga bolezen, npr. bolezen ledvic.
English: In patients with parathyroid carcinoma, mean serum calcium declined from 14.1 mg/dl to 12.4 mg/dl (3.5 mmol/l to 3.1 mmol/l), while in patients with primary HPT, serum calcium levels declined from 12.7 mg/dl to 10.4 mg/dl (3.2 mmol/l to 2.6 mmol/l).
Slovenian: Pri bolnikih s paratiroidnim karcinomom se je povprečna koncentracija kalcija v serumu znižala s 14,1 mg/dl na 12,4 mg/dl (s 3,5 mmol/l na 3,1 mmol/l), pri bolnikih s primarnim hiperparatiroidizmom pa se je koncentracija kalcija v serumu znižala z 12,7 mg/dl na 10,4 mg/dl (s 3,2 mmol/l na 2,6 mmol/l).
English: • to reduce high levels of calcium in the blood (hypercalcaemia) in patients with primary hyperparathyroidism when removal of the parathyroid gland is not possible.
Slovenian: • za zmanjšanje zvišane koncentracije kalcija v krvi (hiperkalciemije) pri bolnikih s primarnim hiperparatiroidizmom ali če odstranitev obščitničnih (paratiroidnih) žlez ni mogoča.
English: Withhold administration of cinacalcet until serum calcium levels reach 8.0 mg/dL (2.0 mmol/L) and/or symptoms of hypocalcaemia have resolved.
Slovenian: Odložite uporabo cinakalceta, dokler koncentracija kalcija v serumu ne doseže 8,0 mg/dl (2,0 mmol/l) in/ali dokler simptomi hipokalciemije ne izginejo.
English: If you are being treated for secondary hyperparathyroidism The recommended starting dose for Cinacalcet Mylan is 30 mg (one tablet) once per day.
Slovenian: Če se zdravite zaradi sekundarnega hiperparatiroidizma Priporočeni začetni odmerek zdravila Cinakalcet Mylan je 30 mg (ena tableta) enkrat na dan.
English: Calcium carbonate: Co-administration of calcium carbonate (single 1,500 mg dose) did not alter the pharmacokinetics of cinacalcet.
Slovenian: Kalcijev karbonat: Sočasna uporaba kalcijevega karbonata (posamičen 1500 mg odmerek) ni spremenila farmakokinetike cinakalceta.
English: Both primary and secondary hyperparathyroidism can cause loss of calcium in the bones, which can lead to bone pain and fractures, problems with blood and heart vessels, kidney stones, mental illness and coma.
Slovenian: Posledice so lahko bolečine v kosteh in zlomi kosti, težave s krvnimi in srčnimi žilami, ledvični kamni, duševna bolezen in koma.
English: Doses titrated up to 300 mg once daily have been administered to patients receiving dialysis without adverse outcome.
Slovenian: Z dializo zdravljeni bolniki so dobivali odmerke, titrirane do 300 mg enkrat na dan, brez neželenih učinkov.
English: If you are being treated for parathyroid cancer or primary hyperparathyroidism The recommended starting dose for Cinacalcet Mylan is 30 mg (one tablet) twice per day.
Slovenian: Če se zdravite zaradi raka na obščitnici ali primarnega hiperparatiroidizma Priporočeni začetni odmerek zdravila Cinakalcet Mylan je 30 mg (ena tableta) dvakrat na dan.
English: < 8.4 mg/dL (2.1 mmol/L) and > 7.5 mg/dL (1.9 mmol/L) or persistent symptoms of hypocalcaemia despite attempts to increase serum calcium
Slovenian: < 8,4 mg/dl (2,1 mmol/l) in > 7,5 mg/dl (1,9 mmol/l) ali persistentni simptomi hipokalciemije kljub poskusom za zvišanje kalcija v serumu
English: The reduction in PTH is associated with a concomitant decrease in serum calcium levels.
Slovenian: Znižanje PTH spremlja sočasno znižanje koncentracije kalcija v serumu.
English: Please tell your doctor if you experience any of the following which may be signs of low calcium levels: spasms, twitches, or cramps in your muscles, or numbness or tingling in your fingers, toes or around your mouth or seizures, confusion or loss of consciousness while being treated with Cinacalcet Mylan.
Slovenian: Zdravniku morate povedati, če se vam med zdravljenjem z zdravilom Cinakalcet Mylan pojavi kar koli od naslednjega, ker so to možni znaki nizke koncentracije kalcija: kratkotrajni krči mišic, trzanje ali dolgotrajni boleči krči v mišicah, omrtvičenost ali mravljinčenje v prstih rok ali nog ali okrog ust ali napadi krčev (konvulzije), zmedenost ali izguba zavesti.