FrancophonIA/ELRC3.0 huggingface dataset:
English: • Extended prophylaxis of DVT following cancer surgery A double-blind, multicenter trial, compared a four-week and a one-week regimen of enoxaparin sodium prophylaxis in terms of safety and efficacy in 332 patients undergoing elective surgery for abdominal or pelvic cancer.
Croatian: • Produljena profilaksa DVT-a nakon onkološkog kirurškog zahvata Dvostruko slijepo, multicentrično ispitivanje uspoređivalo je sigurnost i djelotvornost četverotjednog i jednotjednog režima profilakse enoksaparinnatrijem u 332 bolesnika podvrgnuta elektivnom onkološkom kirurškom zahvatu u abdomenu ili zdjelici.
English: This could be because of a blood problem with low platelet counts.
Croatian: Do toga može doći zbog niskog broja trombocita u krvi.
English: • Your doctor will decide how much Thorinane to give you.
Croatian: • Vaš će liječnik odrediti koliko ćete lijeka Thorinane primati.
English: If you stop using Thorinane
Croatian: Ako prestanete primjenjivati Thorinane
English: • Large red irregularly shaped skin lesions with or without blisters.
Croatian: • velike crvene kožne lezije nepravilna oblika, koje mogu i ne moraju biti praćene mjehurićima na koži
English: Discard any unused medicine.
Croatian: Sav neiskorišteni lijek bacite.
English: After repeated SC administration of 4,000 IU (40 mg) once daily and 150 IU/kg (1.5 mg/kg) once daily regimens in healthy volunteers, the steady-state is reached on day 2 with an average exposure ratio about 15% higher than after a single dose.
Croatian: Nakon ponovljene supkutane primjene doze od 4000 IU (40 mg) jedanput na dan i 150 IU/kg (1,5 mg/kg) jedanput na dan u zdravih dobrovoljaca, stanje dinamičke ravnoteže postiže se 2. dana, uz prosječan omjer izloženosti koji je približno 15% veći nego nakon jednokratne doze.
English: The site of the procedure should be observed for signs of bleeding or hematoma formation.
Croatian: Mjesto na kojem je proveden zahvat treba promatrati zbog moguće pojave znakova krvarenja ili nastanka hematoma.
English: Absorption The absolute bioavailability of enoxaparin sodium after SC injection, based on anti-Xa activity, is close to
Croatian: Apsolutna bioraspoloživost enoksaparinnatrija nakon supkutane injekcije, na temelju anti-Xa aktivnosti, iznosi gotovo 100%.
English: • Thorinane is added to the tube leaving the body (arterial line) at the start of the dialysis session.
Croatian: • Thorinane se dodaje u cijev koja izlazi iz tijela (arterijsku liniju) na početku dijalize.
English: In a double blind multicenter, parallel group study, enoxaparin sodium 2,000 IU (20 mg) or 4,000 IU (40 mg) once a day SC was compared to placebo in the prophylaxis of DVT in medical patients with severely restricted mobility during acute illness (defined as walking distance of <10 meters for ≤3 days).
Croatian: U dvostruko slijepom, multicentričnom ispitivanju s paralelnim skupinama, enoksaparinnatrij u dozi od 2000 IU (20 mg) ili 4000 IU (40 mg) supkutano jedanput na dan uspoređivao se s placebom u profilaksi DVT-a u medikamentozno liječenih bolesnika s izuzetno ograničenom pokretljivošću tijekom akutne bolesti (što se definiralo kao duljina hodne pruge < 10 metara tijekom ≤ 3 dana).
English: The administration should be alternated between the left and right anterolateral or posterolateral abdominal wall.
Croatian: Lijek treba primjenjivati u anterolateralnu ili posterolateralnu stijenku abdomena, naizmjence na lijevu i desnu stranu.
English: Placebo once a day SC n (%)
Croatian: Placebo jedanput na dan supkutano n (%)
English: Enoxaparin sodium prophylaxis for four weeks after surgery for abdominal or pelvic cancer significantly reduced the incidence of venographically demonstrated thrombosis, as compared with enoxaparin sodium prophylaxis for one week.
Croatian: Profilaksa enoksaparinnatrijem tijekom četiri tjedna nakon onkološkog kirurškog zahvata u abdomenu ili zdjelici značajno je snizila incidenciju tromboze potvrđene venografijom u usporedbi s jednotjednom profilaksom enoksaparinnatrijem.
English: Thorinane can be used for two different types of heart attack called STEMI (ST segment elevation myocardial infarction) or Non STEMI (NSTEMI).
Croatian: Thorinane se može primjenjivati za dvije različite vrste srčanog udara, koje se zovu infarkt miokarda s elevacijom ST-segmenta (engl.
English: In patients with severe renal impairment (creatinine clearance <30 mL/min), the AUC at steady state is significantly increased on average by 65% after repeated SC 4,000 IU (40 mg) once daily doses (see sections 4.2 and 4.4).
Croatian: U bolesnika s teškim oštećenjem bubrežne funkcije (klirens kreatinina < 30 ml/min), AUC u stanju dinamičke ravnoteže značajno je povišen za prosječno 65% nakon ponovljene supkutane primjene doze od 4000 IU (40 mg) jedanput na dan (vidjeti dijelove 4.4 i
English: A linear relationship between anti-Xa plasma clearance and creatinine clearance at steady-state has been observed, which indicates decreased clearance of enoxaparin sodium in patients with reduced renal function.
Croatian: Primijećen je linearan odnos između plazmatskog klirensa anti-Xa aktivnosti i klirensa kreatinina u stanju dinamičke ravnoteže, što upućuje na smanjen klirens enoksaparinnatrija u bolesnika sa smanjenom bubrežnom funkcijom.
English: It is administered through the arterial line of a dialysis circuit for the prevention of thrombus formation in the extra corporeal circulation during haemodialysis.
Croatian: Primjenjuje se kroz arterijsku liniju sustava za dijalizu radi sprječavanja nastanka krvnih ugrušaka u izvantjelesnoj cirkulaciji tijekom hemodijalize.
English: • General
Croatian: • Općenito
English: Initiate dosing with 75 IU/kg (0.75 mg/kg) SC every 12 hours (maximum 7,500 IU (75 mg) for each of the first two SC doses only, followed by 75 IU/kg (0.75 mg/kg) SC dosing for the remaining doses).
Croatian: Primjenu treba započeti supkutanom dozom od 75 IU/kg (0,75 mg/kg) svakih 12 sati (najviše 7500 IU [75 mg] samo za svaku od prve dvije supkutane doze, nakon kojih se liječenje nastavlja supkutanim dozama od 75 IU/kg [0,75 mg/kg]).
English: • Medicinal products increasing potassium levels:
Croatian: • Lijekovi koji povisuju razinu kalija:
English: The treatment benefits of enoxaparin sodium, evident for a number of efficacy outcomes, emerged at 48 hours, at which time there was a 35 percent reduction in the relative risk of myocardial re-infarction, as compared with treatment with unfractionated heparin (p<0.001).
Croatian: Terapijska korist enoksaparinnatrija, koja je primijećena kod niza ishoda djelotvornosti, nastupila je nakon 48 sati, kada je zabilježeno smanjenje relativnog rizika od ponovljenog infarkta miokarda za 35% u usporedbi s liječenjem nefrakcioniranim heparinom (p < 0,001).
English: • The usual dose is 150 IU (1.5 mg) for every kilogram of your weight each day or 100 IU (1 mg) for every kilogram of your weight twice a day.
Croatian: • Uobičajena doza je 150 IU (1,5 mg) po kilogramu tjelesne težine jedanput na dan ili 100 IU (1 mg) po kilogramu tjelesne težine dvaput na dan.
English: When given at a dose of 4,000 IU (40 mg) once a day SC, enoxaparin sodium significantly reduced the incidence of VTE as compared to placebo.
Croatian: Kada se primjenjivao u dozi od 4000 IU (40 mg) s.c. jedanput na dan, enoksaparinnatrij je značajno snizio incidenciju VTE-a u odnosu na placebo.
English: • Common: Haemorrhage, haemorrhagic anaemia*, thrombocytopenia, thrombocytosis
Croatian: • Često: krvarenje, hemoragijska anemija*, trombocitopenija, trombocitoza
English: • Stop blood clots forming in the tubes of your dialysis machine (used for people with severe kidney problems).
Croatian: • sprječavanje nastanka krvnih ugrušaka u cijevima uređaja za dijalizu (koji se koristi u osoba s teškim bubrežnim tegobama)
English: Pharmacotherapeutic group: Antithrombotic agents, heparin group.
Croatian: Farmakoterapijska skupina: antitrombotički agensi, skupina heparina.
English: Enoxaparin sodium is not recommended for patients with end stage renal disease (creatinine clearance <15 mL/min) due to lack of data in this population outside the prevention of thrombus formation in extra corporeal circulation during haemodialysis.
Croatian: Enoksaparinnatrij se ne preporučuje za bolesnike u terminalnoj fazi bubrežne bolesti (klirens kreatinina < 15 ml/min) zbog nedovoljno podataka o primjeni u toj populaciji kod svih indikacija osim sprječavanja nastanka krvnih ugrušaka u izvantjelesnoj cirkulaciji tijekom hemodijalize.
English: Enoxaparin sodium may be safely administered with normal saline solution (0.9%) or 5% dextrose in water (see section 4.2).
Croatian: Enoksaparinnatrij se može sigurno primjenjivati s fiziološkom otopinom (0,9%) ili vodenom otopinom glukoze (5%) (vidjeti dio 4.2).
English: Renal impairment (see sections 4.4 and 5.2)
Croatian: Oštećenje funkcije bubrega (vidjeti dijelove 4.4 i 5.2).
English: In order to improve the LMWH traceability, it is recommended that health care professionals record the trade name and batch number of the administered product in the patient file.
Croatian: Kako bi se unaprijedila sljedivost heparina niske molekulske mase, preporučuje se da zdravstveni radnici zabilježe zaštićeni naziv i broj serije primijenjenog lijeka u bolesnikov zdravstveni karton.
English: • The usual dose is 75 IU (0.75 mg) for every kilogram of your weight, every 12 hours.
Croatian: • Uobičajena doza je 75 IU (0,75 mg) po kilogramu tjelesne težine svakih 12 sati.
English: For patients currently receiving a DOAC, the first dose of enoxaparin sodium should be given at the time the next DOAC dose would be taken.
Croatian: U bolesnika koji trenutno primaju DOAK, prvu dozu enoksaparinnatrija treba primijeniti u vrijeme kada je bolesnik trebao uzeti sljedeću dozu DOAK-a.
English: However, since renal function is known to decline with age, elderly patients may show reduced elimination of enoxaparin sodium (see sections 4.2 and 4.4).
Croatian: Međutim, poznato je da se bubrežna funkcija smanjuje s porastom dobi, pa eliminacija enoksaparinnatrija može biti smanjena u starijih bolesnika (vidjeti dijelove 4.2 i 4.4).
English: For the initial 3,000 IU (30 mg) bolus, using an enoxaparin sodium graduated pre-filled syringe, expel the excessive volume to retain only 3,000 IU (30 mg) in the syringe.
Croatian: Za početnu bolusnu dozu od 3000 IU (30 mg), uzmite enoksaparinnatrij u graduiranoj napunjenoj štrcaljki i izbacite višak volumena tako da u njoj ostane samo 3000 IU (30 mg) lijeka.
English: The pre-filled disposable syringe is ready for immediate use.
Croatian: Napunjena štrcaljka za jednokratnu uporabu odmah je spremna za korištenje.
English: In a study conducted in patients with advanced cirrhosis treated with enoxaparin sodium 4,000 IU (40 mg) once daily, a decrease in maximum anti-Xa activity was associated with an increase in the severity of hepatic impairment (assessed by Child-Pugh categories).
Croatian: U ispitivanju provedenom u bolesnika s uznapredovalom cirozom liječenih enoksaparinnatrijem u dozi od 4000 IU (40 mg) jedanput na dan, smanjenje vršne anti-Xa aktivnosti bilo je povezano s povećanjem težine oštećenja jetrene funkcije (koja se ocjenjivala prema Child-Pugh klasifikaciji).
English: Each mL contains 100 mg enoxaparin sodium.
Croatian: Jedan ml sadrži 100 mg enoksaparinnatrija.
English: To obtain a 300 IU/mL (3 mg/mL) solution, using a 6,000 IU (60 mg) enoxaparin sodium pre-filled syringe, it is recommended to use a 50 mL infusion bag (i.e. using either normal saline solution (0.9%) or 5% dextrose in water) as follows:
Croatian: Da bi se dobila otopina od 300 IU/ml (3 mg/ml) kada se koristi napunjena brizgalica sa 6000 IU (60 mg) enoksaparinnatrija, preporučuje se upotrijebiti infuzijsku vrećicu volumena 50 ml (s fiziološkom otopinom [0,9%] ili vodenom otopinom glukoze [5%]) na sljedeći način: Štrcaljkom izvucite 30 ml iz infuzijske vrećice i bacite tekućinu.
English: • History of immune mediated heparin-induced thrombocytopenia (HIT) within the past 100 days or in the presence of circulating antibodies (see also section 4.4 );
Croatian: • anamnezom imunološki posredovane heparinom izazvane trombocitopenije (HIT) u prethodnih 100 dana ili prisutnošću cirkulirajućih protutijela (vidjeti i dio 4.4)
English: Enoxaparin sodium can be administered SC either as a once daily injection of 150 IU/kg (1.5 mg/kg) or as twice daily injections of 100 IU/kg (1 mg/kg).
Croatian: Enoksaparinnatrij se može primijeniti supkutano kao jedna injekcija dnevno od 150 IU/kg (1,5 mg/kg) ili kao dvije injekcije dnevno od 100 IU/kg (1 mg/kg).
English: The 2 hours preoperative initiation of enoxaparin sodium 2,000 IU (20 mg) is not compatible with neuraxial anaesthesia.
Croatian: Uvođenje enoksaparinnatrija u dozi od 2000 IU (20 mg) 2 sata prije operacije nije kompatibilno s neuraksijalnom anestezijom.
English: The occurrence of total and major bleeding were respectively 8.6% and 1.1% in the placebo group, 11.7% and 0.3% in the enoxaparin sodium 2,000 IU (20 mg) group and 12.6% and 1.7% in the enoxaparin sodium 4,000 IU (40 mg) group.
Croatian: Stopa svih krvarenja i velikih krvarenja iznosila je 8,6% odnosno 1,1% u skupini koja je primala placebo, 11,7% odnosno 0,3% u skupini liječenoj enoksaparinnatrijem u dozi od 2000 IU (20 mg) te 12,6% odnosno 1,7% u skupini koja je primala enoksaparinnatrij u dozi od 4000 IU (40 mg).
English: Inject the complete contents of the 6,000 IU (60 mg) enoxaparin sodium pre-filled syringe into the 20 mL remaining in the bag.
Croatian: Injicirajte sav sadržaj napunjene štrcaljke sa 6000 IU (60 mg) enoksaparinnatrija u 20 ml otopine koja je preostala u vrećici.
English: • Skin rash (hives, urticaria).
Croatian: • kožni osip (koprivnjača)
English: The oral absorption of enoxaparin sodium is unlikely.
Croatian: Oralna apsorpcija enoksaparinnatrija nije izgledna.
English: The beneficial effect of enoxaparin sodium on the primary end point was consistent across key subgroups including age, gender, infarct location, history of diabetes, history of prior myocardial infarction, type of fibrinolytic administered, and time to treatment with study drug.
Croatian: Povoljan učinak enoksaparinnatrija na primarnu mjeru ishoda bio je dosljedan u svim ključnim podskupinama, uključujući podskupine prema dobi, spolu, mjestu infarkta, šećernoj bolesti u anamnezi, infarktu miokarda u anamnezi, vrsti primijenjenog fibrinolitika i vremenu do liječenja ispitivanim lijekom.
English: o For patients managed with PCI, if the last dose of enoxaparin sodium SC was given less than 8 hours before balloon inflation, no additional dosing is needed.
Croatian: o U bolesnika koji se podvrgavaju perkutanoj koronarnoj intervenciji, ako je posljednja supkutana doza enoksaparinnatrija primijenjena manje od 8 sati prije napuhavanja balona, nije potrebna dodatna doza.
English: After repeated SC 150 IU/kg (1.5 mg/kg) once daily dosing, mean AUC of anti-Xa activity is marginally higher at steady state in obese healthy volunteers (BMI 30-48 kg/m2) compared to non-obese control subjects, while maximum plasma anti-Xa activity level is not increased.
Croatian: Nakon ponovljene primjene supkutane doze od 150 IU/kg (1,5 mg/kg) jedanput na dan, srednja vrijednost AUC-a anti-Xa aktivnosti u stanju dinamičke ravnoteže bila je neznatno viša u pretilih zdravih dobrovoljaca (ITM: 30 - 48 kg/m2) nego u nepretilih kontrolnih ispitanika, dok vršna plazmatska anti-Xa aktivnost nije bila povećana.
English: Subcutaneous, intravenous use.
Croatian: Potkožna primjena, primjena u venu.
English: • For treatment of unstable angina and NSTEMI, the recommended dose of enoxaparin sodium is 100 IU/kg (1 mg/kg) every 12 hours by SC injection administered in combination with antiplatelet therapy.
Croatian: • Za liječenje nestabilne angine i NSTEMI-ja, preporučena doza enoksaparinnatrija je 100 IU/kg (1 mg/kg) svakih 12 sati s.c. injekcijom, u kombinaciji s antitrombocitnom terapijom.
English: The use of enoxaparin sodium for thromboprophylaxis in pregnant women with mechanical prosthetic heart valves has not been adequately studied.
Croatian: Primjena enoksaparinnatrija za tromboprofilaksu u trudnica s mehaničkim umjetnim srčanim zaliscima nije adekvatno ispitana.
English: 100 IU/kg (1 mg/kg) body weight SC once daily
Croatian: 100 IU/kg (1 mg/kg) tjelesne težine s.c. jedanput na dan
English: • History of HIT (>100 days)
Croatian: • Heparinom izazvana trombocitopenija (HIT) u anamnezi (> 100 dana)
English: Although no dose adjustment is recommended in patients with moderate (creatinine clearance 3050 mL/min) and mild (creatinine clearance 50-80 mL/min) renal impairment, careful clinical monitoring is advised.
Croatian: Iako se ne preporučuje prilagođavanje doze u bolesnika s umjerenim (klirens kreatinina: 30 - 50 ml/min) i blagim (klirens kreatinina: 50 - 80 ml/min) oštećenjem bubrežne funkcije, preporučuje se pažljivo kliničko praćenje.
English: Enoxaparin sodium should be used with caution in patients with hepatic impairment due to an increased potential for bleeding.
Croatian: Enoksaparinnatrij treba primjenjivati uz oprez u bolesnika s oštećenjem jetrene funkcije zbog povećane mogućnosti krvarenja.
English: The safety and efficacy of enoxaparin sodium in paediatric population have not been established.
Croatian: Sigurnost i djelotvornost enoksaparinnatrija u pedijatrijskih bolesnika nisu ustanovljene.
English: Therefore, for patients on enoxaparin sodium, the PCI was to be performed on enoxaparin sodium (no switch) using the regimen established in previous studies i.e. no additional dosing, if last SC administration given less than 8 hours before balloon inflation, IV bolus of 30 IU/ kg (0.3 mg/kg) enoxaparin sodium, if the last SC administration given more than 8 hours before balloon inflation.
Croatian: Dakle, u bolesnika koji su primali enoksaparinnatrij PCI je proveden uz primjenu enoksaparinnatrija (bez prelaska na drugi lijek) prema režimu utvrđenom u prethodnim ispitivanjima, tj. bez dodatne doze ako je posljednja supkutana doza primijenjena manje od 8 sati prije napuhavanja balona, odnosno uz intravensku bolusnu dozu enoksaparinnatrija od 30 IU/kg (0,3 mg/kg) ako je posljednja supkutana doza primijenjena više od 8 sati prije napuhavanja balona.
English: 2) Stopping blood clots from forming in your blood.
Croatian: 2) Sprječava nastanak krvnih ugrušaka u krvi.
English: In lactating rats, the passage of enoxaparin or its metabolites in milk is very low.
Croatian: Enoksaparin ili njegovi metaboliti u vrlo su maloj mjeri prelazili u mlijeko ženki štakora u laktaciji.
English: 1 x 3,000 IU (30 mg) IV bolus plus 100 IU/kg (1 mg/kg) body weight SC and then 100 IU/kg (1 mg/kg) body weight SC every 24 hours
Croatian: 1 x 3000 IU (30 mg) i.v. bolusom plus 100 IU/kg (1 mg/kg) tjelesne težine s.c., a zatim 100 IU/kg (1 mg/kg) tjelesne težine s.c. svaka 24 sata
English: Beyond its anti-Xa/IIa activity, further antithrombotic and anti-inflammatory properties of enoxaparin have been identified in healthy subjects and patients as well as in non-clinical models.
Croatian: Osim anti-Xa i anti-IIa aktivnosti, u zdravih dobrovoljaca i bolesnika te u nekliničkim modelima utvrđena su i dodatna antitrombotska i protuupalna svojstva enoksaparina.
English: Enoxaparin sodium is administered by deep SC injection.
Croatian: Enoksaparinnatrij se primjenjuje dubokom supkutanom injekcijom.
English: • Acute coronary syndrome: - Treatment of unstable angina and Non ST-segment elevation myocardial infarction (NSTEMI), in combination with oral acetylsalicylic acid.
Croatian: • akutni koronarni sindrom: - liječenje nestabilne angine pektoris i infarkta miokarda bez elevacije ST-segmenta (engl. non-ST segment elevation myocardial infarction, NSTEMI), u kombinaciji s peroralnom primjenom acetilsalicilatne kiseline - liječenje akutnog infarkta miokarda s elevacijom ST-segmenta (engl.
English: To avoid bruising, do not rub the injection site after you have injected yourself.
Croatian: Kako bi se izbjeglo stvaranje modrice, nakon što ste si injicirali lijek nemojte trljati mjesto injekcije.
English: Paediatric population The safety and efficacy of enoxaparin sodium in paediatric population have not been established.
Croatian: Pedijatrijska populacija Sigurnost i djelotvornost enoksaparinnatrija u pedijatrijskih bolesnika nisu ustanovljene.
English: To avoid the possible mixture of enoxaparin sodium with other drugs, the IV access chosen should be flushed with a sufficient amount of saline or dextrose solution prior to and following the IV bolus administration of enoxaparin sodium to clear the port of drug.
Croatian: Da bi se izbjeglo potencijalno miješanje enoksaparinnatrija s drugim lijekovima, odabrani intravenski pristup treba isprati dostatnom količinom fiziološke otopine ili otopine glukoze prije i nakon intravenske bolusne primjene enoksaparinnatrija kako bi se uklonili tragovi lijekova s otvora intravenske linije (porta).
English: • Uncommon: Hepatocellular liver injury *
Croatian: • Manje često: hepatocelularno oštećenje jetre*
English: For dosage in elderly patients with impaired kidney function, see below “renal impairment” and section 4.4.
Croatian: Za doziranje u starijih bolesnika s oštećenjem bubrežne funkcije vidjeti odlomak "Oštećenje funkcije bubrega" u nastavku i dio 4.4).
English: C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING
Croatian: OSTALI UVJETI I ZAHTJEVI ODOBRENJA
English: If you are breast-feeding or plan to breast-feed, you should ask your doctor for advice before taking this medicine.
Croatian: Ako dojite ili planirate dojiti, obratite se svom liječniku za savjet prije nego primijenite ovaj lijek.
English: For acute STEMI, treatment is to be initiated with a single IV bolus injection immediately followed by a SC injection.
Croatian: Kod akutnog STEMI-ja, liječenje treba započeti jednokratnom intravenskom bolusnom injekcijom, nakon koje se odmah primjenjuje supkutana injekcija.
English: Solution for injection in pre-filled syringe 2 pre-filled syringes
Croatian: Otopina za injekciju u napunjenoj štrcaljki 2 napunjene štrcaljke 10 napunjenih štrcaljki
English: - Check the syringe is not damaged and the medicine in it is a clear solution.
Croatian: - Provjerite kako biste bili sigurni da je štrcaljka neoštećena i da je otopina koju sadrži prozirna.
English: For patients with creatinine clearance [15-30] mL/min, consider doubling the timing of puncture/catheter placement or removal to at least 48 hours.
Croatian: U bolesnika s klirensom kreatinina od 15 do 30 ml/min, razmotrite udvostručenje vremena do uboda/uvođenja ili uklanjanja katetera na najmanje 48 sati.
English: Detailed information is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljnije informacije dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: Preoperative initiation (2 hours before surgery) of enoxaparin sodium 2,000 IU (20 mg) was proven effective and safe in moderate risk surgery.
Croatian: Uvođenje enoksaparinnatrija u dozi od 2000 IU (20 mg) 2 sata prije kirurškog zahvata pokazalo se učinkovitim i sigurnim kod umjereno rizičnih kirurških zahvata.
English: • For treatment of acute STEMI, the recommended dose of enoxaparin sodium is a single intravenous (IV) bolus of 3,000 IU (30 mg) plus a 100 IU/kg (1 mg/kg) SC dose followed by 100 IU/kg (1 mg/kg) administered SC every 12 hours (maximum 10,000 IU (100 mg) for each of the first two SC doses).
Croatian: • Za liječenje akutnog STEMI-ja, preporučena doza enoksaparinnatrija je jednokratni intravenski (i.v.) bolus od 3000 IU (30 mg) plus supkutana doza od 100 IU/kg (1 mg/kg), nakon koje slijedi supkutana primjena doze od 100 IU/kg (1 mg/kg) svakih 12 sati (najviše 10 000 IU (100 mg) za svaku od prve dvije supkutane doze).
English: For patients with creatinine clearance [15-30] mL/min, consider doubling the timing of puncture/catheter placement or removal to at least 24 hours.
Croatian: U bolesnika s klirensom kreatinina od 15 do 30 ml/min, razmotrite udvostručenje vremena do uboda/uvođenja ili uklanjanja katetera na najmanje 24 sata.
English: Following repeated SC administration no accumulation takes place.
Croatian: Nakon ponovljene supkutane primjene ne dolazi do nakupljanja.
English: • Obese Patients
Croatian: • Pretili bolesnici