FrancophonIA/ELRC3.0 huggingface dataset:
English: Administer antipyretics, oxygen, intravenous fluids and/or low-dose vasopressors as needed.
Croatian: Primijeniti antipiretike, kisik, infuzijske otopine i/ili vazopresore u niskoj dozi prema potrebi.
English: Tumour necrosis factor (TNF) antagonists are not recommended for management of Kymriah-associated cytokine release syndrome.
Croatian: Antagonisti faktora nekroze tumora (TNF) ne preporučuju se za zbrinjavanje sindroma otpuštanja citokina povezanog s lijekom Kymriah.
English: The efficacy of Kymriah was evaluated through the primary endpoint of best overall response rate (ORR), which includes complete response (CR) and partial response (PR) as determined by Independent Review Committee (IRC) assessment as well as secondary endpoints including duration of response (Table 6).
Croatian: Djelotvornost lijeka Kymriah ocjenjivala se pomoću mjere primarnog ishoda u vidu najbolje ukupne stope odgovora (engl. overall response rate, ORR), koja uključuje potpuni odgovor (CR) i djelomični odgovor (PR) prema procjeni Neovisnog povjerenstva za ocjenjivanje (IRC), kao i pomoću mjera sekundarnog ishoda koje uključuju trajanje odgovora (Tablica 6).
English: If you have leukaemia this might include fever, feeling weak, bleeding gums, bruising.
Croatian: Ako imate leukemiju to može uključivati vrućicu, osjećaj slabosti, krvarenje desni, stvaranje modrica.
English: • Diffuse large B-cell lymphoma (DLBCL) - another form of cancer that affects some types of white blood cells, mostly in the lymph nodes.
Croatian: • Difuznog B-velikostaničnog limfoma (DLBCL) - drugi oblik raka koji zahvaća neke vrste leukocita, uglavnom u limfnim čvorovima.
English: Kymriah is for autologous use only.
Croatian: Kymriah je namijenjen samo za autolognu primjenu.
English: Table 8 Cellular kinetic parameters of tisagenlecleucel in r/r DLBCL patients by clinical response at month 3
Croatian: Tablica 8 Parametri kinetike stanica tisagenlekleucela u bolesnika s r/r DLBCL-om prema kliničkom odgovoru u 3. mjesecu
English: There is no experience with manufacturing Kymriah for patients with a positive test for active HBV, HCV or HIV.
Croatian: Trenutačno nema iskustva s proizvodnjom lijeka Kymriah za bolesnike s pozitivnim testom na aktivni HBV, HCV ili HIV.
English: For special precautions for disposal see section 6.6.
Croatian: Za posebne mjere opreza kod odlaganja vidjeti dio 6.6.
English: Giving blood to make Kymriah Kymriah is made from your own white blood cells.
Croatian: Davanje krvi za pripravljanje lijeka Kymriah Kymriah se pripravlja od Vaših leukocita.
English: Encephalopathy includes depressed level of consciousness, mental status changes, automatism, cognitive disorder, confusional state, disturbance in attention, encephalopathy, posterior reversible encephalopathy syndrome, somnolence, lethargy, memory impairment, metabolic encephalopathy and thinking abnormal.
Croatian: Encefalopatija uključuje sniženu razinu svijesti, promjene mentalnog stanja, automatizam, kognitivni poremećaj, stanje konfuzije, poremećaj pozornosti, encefalopatiju, sindrom posteriorne reverzibilne encefalopatije, somnolenciju, letargiju, narušeno pamćenje, metaboličku encefalopatiju i poremećeno razmišljanje.
English: Risk factors for developing severe cytokine release syndrome in adult DLBCL patients are not known.
Croatian: Čimbenici rizika za razvoj teškog sindroma otpuštanja citokina u odraslih bolesnika s DLBCL-om nisu poznati.
English: The overall incidence (all grades) was 65% (unspecified 49%, viral 32%, bacterial 24% and fungal 15%) (see section 4.4).
Croatian: Ukupna incidencija (svih stupnjeva) iznosila je 65% (neodređene 49%, virusne 32%, bakterijske 24% i gljivične 15%) (vidjeti dio 4.4).
English: In DLBCL patients severe infections (Grade 3 and higher), which can be life-threatening or fatal, occurred in 32% of patients.
Croatian: U bolesnika s DLBCL-om teške infekcije (3. i višeg stupnja), koje mogu biti opasne po život ili smrtonosne, pojavile su se u 32% bolesnika.
English: Intravenous use Do not use leukocyte depleting filter.
Croatian: Intravenski Ne koristiti filtar za leukocitnu depleciju.
English: Table 7 Cellular kinetic parameters of tisagenlecleucel in paediatric and young adult r/r B-cell ALL (Studies B2202 and B2205J)
Croatian: Tablica 7 Parametri kinetike stanica tisagenlekleucela u pedijatrijskih i mladih odraslih bolesnika s r/r ALL-om B-stanica (ispitivanja B2202 i B2205J)
English: All contents of the infusion bags should be infused.
Croatian: Potrebno je infundirati cjelokupni sadržaj vrećica za infuziju.
English: Ischaemic cerebral infarction
Croatian: Ishemijski moždani udar
English: The majority of patients who had cytopenias at day 28 following Kymriah treatment resolved to Grade 2 or below within three months after treatment.
Croatian: U većine bolesnika koji su bili citopenični 28. dan nakon terapije lijekom Kymriah, unutar tri mjeseca nakon liječenja došlo je do smanjenja citopenije na 2. ili niži stupanj.
English: 43% of the patients experienced an infection of any type within 8 weeks after Kymriah infusion.
Croatian: U 43% bolesnika razvila se neka infekcija bilo kojeg tipa u roku od 8 tjedana od infuzije lijeka Kymriah.
English: Disseminated intravascular coagulation
Croatian: Diseminirana intravaskularna koagulacija
English: There is limited evidence that race/ethnicity impact the expansion of Kymriah in paediatric and young adult ALL and DLBCL patients.
Croatian: Postoje ograničeni dokazi da rasa/etničko podrijetlo utječu na ekspanziju lijeka Kymriah u pedijatrijskih i mladih odraslih bolesnika s ALL-om i DLBCL-om.
English: Grade 3 and 4 adverse reactions were more often observed within the initial 8 weeks post-infusion (85%) compared to after 8 weeks post-infusion (49%).
Croatian: Nuspojave 3. i 4. stupnja češće su zabilježene u prvih 8 tjedana nakon infuzije (85%) u usporedbi s razdobljem poslije 8. tjedna nakon infuzije (49%).
English: Carcinogenicity and mutagenicity
Croatian: Kancerogenost i mutagenost
English: This medicine contains genetically-modified blood cells.
Croatian: Ovaj lijek sadrži genetički modificirane krvne stanice.
English: If there is a delay of more than 4 weeks between completing lymphodepleting chemotherapy and the infusion and the WBC count is >1,000 cells/μL, then the patient should be re-treated with lymphodepleting chemotherapy prior to receiving Kymriah.
Croatian: Ako razmak između završetka kemoterapije za limfocitnu depleciju i infuzije bude više od 4 tjedna, a broj leukocita je >1000 stanica/μL, bolesnik treba ponovno primiti kemoterapiju za limfocitnu depleciju prije nego što primi lijek Kymriah.
English: The product should be administered immediately after thawing.
Croatian: Lijek je potrebno odmah primijeniti nakon odmrzavanja.
English: Oedema includes oedema peripheral, generalised oedema, localised oedema and face oedema.
Croatian: Edem uključuje periferni edem, generalizirani edem, lokalizirani edem i edem lica.
English: Additional organ system adverse reactions, including transient cardiac insufficiency and arrhythmia, renal insufficiency, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT) and elevated bilirubin have been observed.
Croatian: Opažene su nuspojave koje zahvaćaju druge organske sustave, uključujući prolaznu srčanu insuficijenciju i aritmiju, bubrežnu insuficijenciju, povišenu aspartat aminotransferazu (AST), povišenu alanin aminotransferazu (ALT) i povišeni bilirubin.
English: Signs and symptoms of TLS should be monitored and events managed according to standard guidelines.
Croatian: Potrebno je pratiti znakove i simptome TLS-a te zbrinuti događaje prema standardnim smjernicama.
English: Administration of low-dose steroids as per the cytokine release syndrome treatment algorithm does not impact the expansion and persistence of CAR-T cells.
Croatian: Primjena niske doze steroida prema algoritmu liječenja sindroma otpuštanja citokina ne utječe na ekspanziju i perzistentnost CAR T-stanica.
English: - Your doctor will give you a Patient Alert Card. Read it carefully and follow the instructions on it. - Always show the Patient Alert Card to the doctor or nurse when you see them or if you go to hospital.
Croatian: - Uvijek pokažite karticu s upozorenjima za bolesnika liječniku ili medicinskoj sestri pri svakom posjetu liječniku ili odlasku u bolnicu.
English: • B-cell acute lymphoblastic leukaemia (B-cell ALL) - a form of cancer that affects some other types of white blood cells.
Croatian: • Akutne limfoblastične leukemije B-stanica (ALL B-stanica) - oblik raka koji zahvaća neke druge vrste leukocita.
English: Grade 3 and 4 adverse reactions were reported in 89% of patients.
Croatian: Nuspojave 3. i 4. stupnja bile su zabilježene u 89% bolesnika.
English: Abdominal compartment syndrome
Croatian: Sindrom abdominalnog odjeljka
English: Kymriah intravenous infusion should be administered by a healthcare professional experienced with immunosuppressed patients and prepared to manage anaphylaxis.
Croatian: Intravensku infuziju lijeka Kymriah mora primijeniti zdravstveni radnik koji ima iskustva s imunosuprimiranim bolesnicima i koji je osposobljen za postupanje u slučaju anafilaksije.
English: Severe febrile neutropenia (Grade 3 or 4) was observed in 36% of paediatric and young adult B-cell ALL patients and 15% of DLBCL patients.
Croatian: Teška febrilna neutropenija (3. ili 4. stupnja) bila je opažena u 36% pedijatrijskih i mladih odraslih bolesnika s ALL-om B-stanica te u 15% bolesnika s DLBCL-om.
English: Grade 3 and 4 adverse reactions were more often observed within the initial 8 weeks post-infusion (83% of patients) compared to after 8 weeks post-infusion (46% of patients).
Croatian: Nuspojave 3. i 4. stupnja češće su opažene tijekom prvih 8 tjedana nakon infuzije (83% bolesnika) u usporedbi s razdobljem poslije 8. tjedna nakon infuzije (46% bolesnika).
English: Women who are breast-feeding should be advised of the potential risk to the breast-fed infant.
Croatian: Žene koje doje potrebno je upozoriti na mogući rizik za dojenče.
English: Tachycardia includes sinus tachycardia and tachycardia.
Croatian: Tahikardija uključuje sinusnu tahikardiju i tahikardiju.
English: To minimise risk of TLS, patients with elevated uric acid or high tumour burden should receive allopurinol, or an alternative prophylaxis, prior to Kymriah infusion.
Croatian: Da bi se smanjio rizik od TLS-a, bolesnici s povišenom mokraćnom kiselinom ili visokim opterećenjem tumorom trebaju primati alopurinol ili drugu profilaksu prije infuzije lijeka Kymriah.
English: Kymriah should be administered as an intravenous infusion through latex-free intravenous tubing without a leukocyte depleting filter, at approximately 10 to 20 mL per minute by gravity flow.
Croatian: Kymriah se mora primijeniti kao intravenska infuzija gravitacijskom metodom kroz set za infuziju bez lateksa i bez filtera za leukocitnu depleciju, brzinom od otprilike 10 do 20 mL u minuti.
English: Febrile neutropenia was frequently observed in patients after Kymriah infusion (see section 4.8) and may be concurrent with cytokine release syndrome.
Croatian: Febrilna neutropenija učestalo je opažena u bolesnika nakon infuzije lijeka Kymriah (vidjeti dio 4.8) i može se javiti istodobno sa sindromom otpuštanja citokina.
English: Kymriah can cause problems such as altered or decreased consciousness, confusion and seizures (fits) in the 8 weeks following infusion.
Croatian: Kymriah može izazvati probleme poput izmijenjene ili smanjene svijesti, smetenosti i epileptičkih napadaja tijekom 8 tjedana nakon primanja lijeka Kymriah.
English: If the infusion bag appears to have been damaged or to be leaking, it should not be infused and should be disposed of according to local biosafety procedures.
Croatian: Ako vrećica za infuziju izgleda kao da je oštećena ili curi, ne smije se infundirati već se mora zbrinuti sukladno nacionalnim smjernicama za biološku sigurnost.
English: Local biosafety guidelines should be followed for disposal.
Croatian: Potrebno je slijediti nacionalne smjernice o biološkoj sigurnosti za zbrinjavanje.
English: • Abnormal blood test results (high level of: phosphorus, magnesium, an enzyme called alkaline phosphatase to help detect liver disease, fibrin d-dimer, serum ferritin; low level of: sodium)
Croatian: • Odstupanja u rezultatima krvnih pretraga (visoka razina: fosfora, magnezija, enzima koji se naziva alkalna fosfataza koji pomaže otkriti bolest jetre, fibrin d-dimera, serumskog feritina;
English: Speech disorders includes speech disorders, dysarthria and aphasia.
Croatian: Poremećaji govora uključuju poremećaje govora, dizartriju i afaziju.
English: Not reached (8.6, NE9) Not reached (8.6, NE)
Croatian: Nije postignut (8,6; NE)
English: Updated reports: September 2019, November
Croatian: Ažurirana izvješća: rujan 2019., studeni 2020.
English: Infused patients
Croatian: Uključeni bolesnici
English: • Adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy.
Croatian: • odraslih bolesnika s recidivirajućim ili refraktornim difuznim B-velikostaničnim limfomom (DLBCL) nakon dvije ili više linija sistemske terapije.
English: Adverse drug reactions from these clinical studies (Table 2) are listed by MedDRA system organ class.
Croatian: Nuspojave iz ovih kliničkih ispitivanja (Tablica 2) navedene su prema klasifikaciji organskih sustava iz Medicinskog rječnika za regulatorne poslove (MedDRA).
English: Contraindications of the lymphodepleting chemotherapy must be considered.
Croatian: Potrebno je uzeti u obzir kontraindikacije za kemoterapiju za limfocitnu depleciju.
English: Prior stem-cell transplantation - n (%)
Croatian: Prethodna transplantacija matičnih stanican (%)
English: Other side effects are listed below.
Croatian: Druge nuspojave navedene su u nastavku.
English: Patients are counted only for the worst grade observed post baseline.
Croatian: Bolesnici se broje samo za najgori stupanj uočen nakon početka ispitivanja.
English: Attention to signs and symptoms of infection should be implemented according to age and standard specific guidelines.
Croatian: Potrebno je reagirati na znakove i simptome infekcije, sukladno dobi i standardnim specifičnim smjernicama.
English: • high fever and chills.
Croatian: • visoka vrućica i zimica.
English: The safety and efficacy of Kymriah treatment in adult patients with relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) who received ≥2 lines of chemotherapy, including rituximab and anthracycline, or relapsed following autologous haematopoietic stem cell transplantation (HSCT), was evaluated in an open-label, pivotal, single-arm study.
Croatian: Sigurnost i djelotvornost liječenja lijekom Kymriah u odraslih bolesnika s recidivirajućim ili refraktornim (r/r) difuznim B-velikostaničnim limfomom (DLBCL) koji su primili ≥2 linije kemoterapije, uključujući rituksimab i antraciklin, ili imali relaps nakon autologne transplantacije krvotvornih matičnih stanica bile su ocijenjene u otvorenom, pivotalnom ispitivanju s jednom skupinom.
English: For storage conditions after thawing of the medicinal product, see section 6.3.
Croatian: Uvjete čuvanja nakon odmrzavanja lijeka vidjeti u dijelu 6.3.
English: Haemoglobin decreased* Lymphocyte count decreased* White blood cell count decreased* Neutrophil count decreased* Platelet count decreased* Aspartate aminotransferase increased Alanine aminotransferase increased Blood bilirubin increased International normalised ratio increased
Croatian: Sniženi hemoglobin* Sniženi broj limfocita* Sniženi broj leukocita* Sniženi broj neutrofila* Sniženi broj trombocita* Povišena aspartat aminotransferaza Povišena alanin aminotransferaza Povišeni bilirubin u krvi Povišeni internacionalni normalizirani omjer (INR)
English: Grade 3 and 4 adverse reactions were reported in 88% of patients.
Croatian: Nuspojave 3. i 4. stupnja bile su zabilježene u 88% bolesnika.
English: Anti-IL-6 based therapy such as tocilizumab has been administered for moderate or severe cytokine release syndrome associated with Kymriah and a minimum of four doses of tocilizumab must be on site and available for administration prior to Kymriah infusion.
Croatian: Terapija koja se temelji na blokiranju IL-6 kao što je tocilizumab primjenjivana je za umjereni ili teški sindrom otpuštanja citokina povezan s lijekom Kymriah te najmanje četiri doze tocilizumaba moraju biti u bolničkom centru prije infuzije lijeka Kymriah i dostupne za primjenu.
English: In B-cell ALL patients severe infections (Grade 3 and higher), which can be life-threatening or fatal, occurred in 44% of patients after Kymriah infusion.
Croatian: U bolesnika s ALL-om B-stanica, teške infekcije (3. i višeg stupnja), koje mogu biti opasne po život ili smrtonosne, pojavile su se u 44% bolesnika nakon infuzije lijeka Kymriah.
English: Serious infections, including life-threatening or fatal infections, occurred frequently in patients after Kymriah infusion (see section 4.8).
Croatian: Ozbiljne infekcije, uključujući one opasne po život ili smrtonosne, zabilježene su učestalo u bolesnika nakon infuzije lijeka Kymriah (vidjeti dio 4.8).
English: To inform and explain to patients: - the risks of CRS and serious neurological adverse reactions associated with KYMRIAH - the need to report the symptoms to their treating doctor immediately - the need to remain in the proximity of the location where KYMRIAH was received for at least
Croatian: Za informiranje i pružanje objašnjenja bolesnicima o: - rizicima od sindroma otpuštanja citokina i ozbiljnih neuroloških nuspojava povezanima s lijekom KYMRIAH - potrebi prijavljivanja simptoma svome liječniku bez odgađanja - potrebi da ostanu u blizini bolnice u kojoj su primili lijek KYMRIAH tijekom najmanje 4 tjedna nakon infuzije lijeka - potrebi da uvijek sa sobom nose karticu s upozorenjima za bolesnika
English: In DLBCL patients, manifestations of encephalopathy and/or delirium occurred in 21% of patients (12% were Grade 3 or 4) within 8 weeks after Kymriah infusion.
Croatian: U bolesnika s DLBCL-om, manifestacije encefalopatije i/ili delirija pojavile su se u 21% bolesnika (12% bilo je 3. ili 4. stupnja) u roku od 8 tjedana nakon infuzije lijeka Kymriah.
English: Febrile neutropenia Leukopenia Lymphopenia Anaemia
Croatian: Febrilna neutropenija Leukopenija Limfopenija Anemija
English: • Swollen ankles, limbs and face
Croatian: • Natečeni zglobovi, udovi i lice
English: Tisagenlecleucel also traffics and persists in cerebrospinal fluid in paediatric and young adult B-cell ALL patients (Study B2101J) for up to 1 year.
Croatian: Tisagenlekleucel također prelazi u cerebrospinalnu tekućinu i perzistira u njoj u pedijatrijskih i mladih odraslih bolesnika s ALL-om B-stanica (ispitivanje B2101J) u razdoblju do 1 godine.
English: This medicine contains 24.3 to 121.5 mg sodium per dose.
Croatian: Ovaj lijek sadrži 24,3 do 121,5 mg natrija po dozi.
English: All contents of the infusion bag(s) should be infused.
Croatian: Potrebno je infundirati cjelokupni sadržaj vrećice (vrećica) za infuziju.
English: Blood fibrinogen decreased Serum ferritin increased Blood alkaline phosphatase increased Fibrin D dimer increased Prothrombin time prolonged a)
Croatian: Produljeno aktivirano parcijalno tromboplastinsko vrijeme Sniženi fibrinogen u krvi Povišeni serumski feritin Povišena alkalna fosfataza u krvi Povišeni fibrin D dimer Produljeno protrombinsko vrijeme a)
English: • You are pregnant, think you may be pregnant, or plan to become pregnant (see sections
Croatian: • ste trudni, mislite da biste mogli biti trudni ili planirate zatrudnjeti (pogledajte dijelove “Trudnoća i dojenje” i “Kontracepcija za žene i muškarce” u nastavku).
English: • Failure of multiple organs
Croatian: • Zatajivanje više organa
English: • Abnormal blood test results (high level of: uric acid, glucose; low level of: phosphorus, calcium,
Croatian: • Odstupanja u rezultatima krvnih pretraga (visoka razina: mokraćne kiseline, glukoze; niska razina: fosfora, kalcija, kalija, magnezija)
English: Concomitant disease
Croatian: Istodobna bolest
English: All patients had leukapheresis products collected and cryopreserved prior to or during study entry.
Croatian: Svim su bolesnicima prikupljeni i krioprezervirani pripravci dobiveni leukaferezom prije ili tijekom uključivanja u ispitivanje.
English: Inspection and thawing of the infusion bag(s)
Croatian: Pregled i odmrzavanje vrećice (vrećica) za infuziju
English: Gender is not a significant characteristic influencing tisagenlecleucel expansion in B-cell ALL and DLBCL patients.
Croatian: Spol nije značajna karakteristika koja utječe na ekspanziju tisagenlekleucela kod bolesnika s ALL-om B-stanica i DLBCL-om.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: Ažurirani RMP treba dostaviti: na zahtjev Europske agencije za lijekove; prilikom svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: Infections and infestationsa)
Croatian: Infekcije i infestacije a)
English: In the ongoing clinical studies in paediatric and young adult B-cell ALL (N=75), cytokine release syndrome was reported in 77% of patients (47% with Grade 3 or 4).
Croatian: U kliničkim ispitivanjima ALL-a B-stanica u pedijatrijskih i mladih odraslih bolesnika (N=75) koja su u tijeku, sindrom otpuštanja citokina je bio prijavljen u 77% bolesnika (47% s 3. ili 4. stupnjem).
English: Therapy should be initiated under the direction of and supervised by a healthcare professional experienced in the treatment of haematological malignancies and trained for administration and management of patients treated with Kymriah.
Croatian: Terapiju mora započeti i nadzirati zdravstveni radnik koji ima iskustva s liječenjem hematoloških zloćudnih bolesti i koji je osposobljen za primjenu lijeka Kymriah te za zbrinjavanje bolesnika koji se njime liječe.
English: Cellular kinetics in adult DLBCL patients
Croatian: Kinetika stanica u odraslih bolesnika s DLBCL-om
English: The quantitative information regarding CAR-positive viable T cells/mL and total cells in the product is presented in the batch-specific documentation accompanying Kymriah.
Croatian: Kvantitativne informacije o koncentraciji CAR-pozitivnih vijabilnih T-stanica/mL i ukupnom broju stanica u lijeku navedene su u dokumentaciji koja se dostavlja uz svaku seriju lijeka Kymriah.
English: See section 2, “Kymriah contains sodium, dimethylsulfoxide (DMSO) and dextran 40”.
Croatian: Pogledajte dio 2, “Kymriah sadrži natrij, dimetilsulfoksid (DMSO) i dekstran 40”.
English: The co-administration of agents known to inhibit T-cell function has not been formally studied.
Croatian: Istodobna primjena tvari za koje je poznato da inhibiraju funkciju T-stanica nije bila formalno ispitivana.
English: In paediatric and young adult B-cell ALL patients, manifestations of encephalopathy and/or delirium occurred in 40% of patients (13% were Grade 3 or 4) within 8 weeks after Kymriah infusion.
Croatian: U pedijatrijskih i mladih odraslih bolesnika s ALL-om B-stanica, manifestacije encefalopatije i/ili delirija pojavile su se u 40% bolesnika (13% bilo je 3. ili 4. stupnja) u roku od 8 tjedana nakon infuzije lijeka Kymriah.
English: Cardiac failure includes cardiac failure, left ventricular dysfunction, cardiac failure congestive and right ventricular dysfunction.
Croatian: Zatajivanje srca uključuje zatajivanje srca, disfunkciju lijeve klijetke, kongestivno zatajivanje srca i disfunkciju desne klijetke.
English: • Dry mouth, sore mouth, bleeding in the mouth, inflammation in the gums
Croatian: • Suha usta, bol u ustima, krvarenje u ustima, upala desni
English: Patients with active CNS leukaemia
Croatian: Bolesnici s aktivnom leukemijom SŽS-a