FrancophonIA/ELRC3.0 huggingface dataset:
English: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom
Slovenian: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom injiciranje in Baytril 10 % raztopina za injiciranje in povezana imena ostaja pozitivno, če se upoštevajo spremembe v informacijah o zdravilu.
English: Opinion following an Article 341 referral for Baytril 2.5% injectable, Baytril 5% injectable and Baytril 10% injectable and their associated names
Slovenian: Mnenje v zvezi z napotitvijo v skladu s členom 340F za zdravila Baytril 2,5 % raztopina za injiciranje, Baytril 5 % raztopina za injiciranje ter Baytril 10 % raztopina za injiciranje in povezana imena
English: Based on the evaluation of the currently available data, the CVMP considered that the benefit-risk profile of Baytril 2.5% injectable, Baytril 5% injectable and Baytril 10% injectable and their associated names remains positive, subject to amendments in the product information.
Slovenian: Na podlagi ovrednotenja trenutno razpoložljivih podatkov je odbor CVMP menil, da razmerje med koristmi in tveganji za zdravila Baytril 2,5 % raztopina za injiciranje, Baytril 5 % raztopina za
English: 28 months.
Slovenian: 28 mesecev
English: After taking one of them, wait at least 2 to 3 hours before taking the other.
Slovenian: Po zaužitju enega od teh zdravil počakajte vsaj 2 do 3 ure, preden vzamete drugo.
English: Date of first authorisation: 18/02/2011 Date of latest renewal: 19/11/2015
Slovenian: Datum prve odobritve: 18/02/2011 Datum zadnjega podaljšanja: 19/11/2015
English: The INR values increased on average by 13% [CI90 6-19%].
Slovenian: Vrednosti INR so se povečale povprečno za 13 % [IZ90 6-19 %].
English: The results are given in Table 2.
Slovenian: Rezultati so podani v preglednici 2.
English: It is estimated that 80-90% of the dose is excreted in faeces, although this has not been confirmed in man.
Slovenian: Ocenjeno je, da se 80-90 % odmerka izloči z blatom, čeprav to pri človeku ni potrjeno.
English: • if you have liver disease;
Slovenian: • če imate bolezen jeter;
English: Entacapone can be taken with or without food (see section 5.2).
Slovenian: Entakapon se lahko jemlje s hrano ali brez nje (glejte poglavje 5.2).
English: The amount of levodopa available to the brain is increased.
Slovenian: Poveča se količina levodope, ki je na razpolago možganom.
English: The major part (95%) of the product excreted in urine is conjugated with glucuronic acid.
Slovenian: Največji delež (95 %) zdravila, ki se izloči z urinom, je konjugiran z glukuronsko kislino.
English: Therefore, do not take Entacapone Teva and iron supplements at the same time.
Slovenian: Zato ne jemljite zdravila Entakapon Teva in dodatkov železa istočasno.
English: 4.5% (0 h 35 min) CI95% 0.93%, 7.97%
Slovenian: 4,5 % (0 h 35 min) IZ95 % 0,93 %, 7,97 %
English: 1 h 20 min CI95% 45 min, 1 h 56 min
Slovenian: 1 h 20 min IZ95 % 45 min, 1 h 56 min
English: In animal studies entacapone was excreted in milk.
Slovenian: V študijah na živalih se je entakapon izločal v mleko.
English: In individual cases, only some of these symptoms and/or findings may be evident.
Slovenian: Pri posameznih primerih se lahko pokažejo le nekateri od teh simptomov ali laboratorijskih izvidov ali obojega.
English: Other important side effects which may occur:
Slovenian: Drugi pomembni neželeni učinki, ki se tudi lahko pojavijo:
English: Cardiac disorders**
Slovenian: Srčne bolezni**
English: • if you are taking certain antidepressants (ask your doctor or pharmacist whether your antidepressive medicine can be taken together with Entacapone Teva);
Slovenian: • če jemljete določene antidepresive (povprašajte svojega zdravnika ali farmacevta, ali lahko jemljete svoje zdravilo proti depresiji skupaj z zdravilom Entakapon Teva);
English: A small amount of entacapone, the (E)-isomer, is converted to its (Z)-isomer.
Slovenian: Majhna količina entakapona, izomera (E), se spremeni v njegovo izomero (Z).
English: Approximately 92% of the dose is eliminated during ß-phase with a short elimination half-life of 30 minutes.
Slovenian: Približno 92 % odmerka se odstrani iz telesa v fazi ß s kratkim razpolovnim časom odstranjevanja iz telesa 30 minut.
English: TEVA Pharmaceutical Works Private Limited Company Pallagi út 13, 4042 Debrecen Hungary
Slovenian: TEVA Pharmaceutical Works Private Limited Company Pallagi út 13, 4042 Debrecen Madžarska
English: Management of acute overdose is symptomatic.
Slovenian: Zdravljenje akutnega prevelikega odmerjanja je simptomatsko.
English: In the event of prolonged or persistent diarrhoea, the medicinal product should be discontinued and appropriate medical therapy and investigations considered.
Slovenian: V primeru dolgotrajne ali trdovratne diareje je treba zdravljenje prekiniti in razmisliti o ustreznem zdravljenju in preiskavah.
English: Entacapone may be used with selegiline (a selective MAO-B inhibitor), but the daily dose of selegiline should not exceed 10 mg.
Slovenian: Entakapon se sme uporabljati s selegilinom (selektivni zaviralec MAO-B), vendar dnevni odmerek selegilina ne sme preseči 10 mg.
English: The (E)-isomer accounts for 95% of the AUC of entacapone.
Slovenian: Izomera (E) predstavlja 95 % AUC entakapona.
English: • if you are allergic to entacapone or any of the other ingredients of this medicine (listed in section 6);
Slovenian: • če ste alergični na entakapon ali katero koli sestavino tega zdravila (navedeno v poglavju 6);
English: Reduction of levodopa dosage decreases the severity and frequency of these reactions.
Slovenian: Zmanjšanje odmerjanja levodope zmanjša stopnjo izraženosti in pogostost teh učinkov.
English: Entacapone and iron preparations should be taken at least 2-3 hours apart (see section 4.8).
Slovenian: Entakapon in pripravke železa je treba jemati s časovnim presledkom vsaj 2-3 ur (glejte poglavje 4.8).
English: Pharmacokinetic interaction with benserazide has not been studied.
Slovenian: Farmakokinetičnih interakcij z benserazidom niso proučevali.
English: Of the metabolites found in urine only about 1% have been formed through oxidation.
Slovenian: Od presnovkov, ki so v urinu, jih le okrog 1 % nastane z oksidacijo.
English: The pharmacokinetic properties of entacapone are similar in both young and elderly adults.
Slovenian: Značilnosti pri bolnikih Farmakokinetične lastnosti entakapona so podobne tako pri mlajših kot pri starejših odraslih osebah.
English: The total clearance of entacapone is about 800 ml/min.
Slovenian: Celotni očistek entakapona je okrog 800 ml/min.
English: Isolated cases of rhabdomyolysis have been reported.
Slovenian: Poročali so o posameznih primerih rabdomiolize.
English: COMT inhibition in red blood cells closely follows the plasma concentrations of entacapone, thus clearly indicating the reversible nature of COMT inhibition.
Slovenian: Inhibicija COMT v rdečih krvničkah je tesno povezana s plazemsko koncentracijo entakapona, kar jasno kaže na reverzibilno naravo inhibicije COMT.
English: Entacapone binds to human albumin binding site II which also binds several other medicinal products, including diazepam and ibuprofen.
Slovenian: Entakapon se veže na humanem albuminu na vezavno mesto II, kamor se vežejo tudi številna druga zdravila, vključno z diazepamom in ibuprofenom.
English: • if you have ever suffered from a rare reaction to antipsychotic medicines called neuroleptic malignant syndrome (NMS).
Slovenian: • če ste kdaj imeli redko reakcijo na antipsihotična zdravila, ki se imenuje nevroleptični maligni sindrom (NMS).
English: Entacapone showed little or no inhibition of other types of P450 isoenzymes (CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP3A and CYP2C19) (see section
Slovenian: Entakapon je le malo oziroma sploh ni zaviral drugih vrst izoencimov P450 (CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP3A in CYP2C19) (glejte poglavje
English: Mogilska 80, 31-546, Krakow Poland
Slovenian: Mogilska 80, 31-546, Krakow Poljska
English: However, in an interaction study with healthy volunteers, entacapone did not change the plasma levels of S-warfarin, while the AUC for R-warfarin increased on average by 18 % [CI90 11-26%].
Slovenian: Vendar v študiji medsebojnega delovanja na zdravih prostovoljcih entakapon ni spremenil plazemskih koncentracij S-varfarina, medtem ko se je AUC za R-varfarin povečala povprečno za 18 % [IZ90
English: The peak concentration (Cmax) in plasma is usually reached about one hour after ingestion of a 200 mg entacapone tablet.
Slovenian: Največja koncentracija (Cmax) v plazmi se navadno doseže približno eno uro po zaužitju 200 mg tablete entakapona.
English: Week 8-24 66.8±14.5
Slovenian: razlika izhodišče teden 8-24 66,8 ± 14,5
English: The safety and efficacy of Entacapone Teva in children below age 18 have not been established.
Slovenian: Varnost in učinkovitost zdravila Entakapon Teva pri otrocih starih do 18 let nista bili dokazani.
English: Clinical interaction studies with diazepam and non-steroidal antiinflammatory medicinal products have not been carried out.
Slovenian: Klinične študije medsebojnega delovanja z diazepamom in nesteroidnimi protivnetnimi zdravili niso opravljene.
English: (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data, since no valid estimate can be derived from clinical trials or epidemiological studies).
Slovenian: Uporabljen je naslednji dogovor: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000), pogostnost neznana (je ni mogoče oceniti iz razpoložljivih podatkov, ker na podlagi kliničnih preskušanj ali epidemioloških študij ni mogoče ugotoviti zanesljivih ocen pogostnosti).
English: • if you have ever suffered from a rare muscle disorder called rhabdomyolysis which was not caused by injury.
Slovenian: • če ste imeli kdaj redko bolezen mišic, ki se imenuje rabdomioliza, in je ni povzročila poškodba.
English: Do not stop taking Entacapone Teva unless your doctor tells you to.
Slovenian: Ne prekinite jemanja zdravila Entakapon Teva, razen če vam to naroči vaš zdravnik.
English: If you experience such effects at the start of treatment with Entacapone Teva you should contact your doctor who may decide to adjust your dosage of levodopa.
Slovenian: Če pri vas pride od takih učinkov na začetku zdravljenja z zdravilom Entakapon Teva, morate obvestiti zdravnika, ki se bo morda odločil, da vam prilagodi odmerjanje levodope.
English: The safety of entacapone in infants is unknown.
Slovenian: Varnost entakapona za dojenčke ni znana.
English: Entacapone is extensively bound to plasma proteins, mainly to albumin.
Slovenian: Entakapon se v veliki meri veže na plazemske beljakovine, predvsem na albumine.
English: EU/1/10/665/001 - 30 tablets EU/1/10/665/002 - 60 tablets EU/1/10/665/003 - 100 tablets EU/1/10/665/004 - 175 tablets
Slovenian: EU/1/10/665/001 - 30 tablet EU/1/10/665/002 - 60 tablet EU/1/10/665/003 - 100 tablet EU/1/10/665/004 - 175 tablet
English: This leads to a higher levodopa AUC.
Slovenian: To povzroči večjo AUC levodope.
English: • if you have a tumour of the adrenal gland (known as pheochromocytoma; this may increase the risk of severe high blood pressure);
Slovenian: • če imate tumor nadledvičnice (ti. feokromocitom, ki lahko poveča tveganje za zelo visok krvni tlak);
English: As there is no experience in pregnant women, entacapone should not be used during pregnancy.
Slovenian: Ker z zdravljenjem z entakaponom pri nosečnicah ni izkušenj, ga med nosečnostjo ne smete uporabljati.
English: Entacapone inhibits the COMT enzyme mainly in peripheral tissues.
Slovenian: Entakapon zavira encim COMT večinoma v perifernih tkivih.
English: EU/1/10/665/002 - 60 tablets EU/1/10/665/003 - 100 tablets EU/1/10/665/004 - 175 tablets
Slovenian: EU/1/10/665/002 - 60 tablet EU/1/10/665/003 - 100 tablet EU/1/10/665/004 - 175 tablet
English: After absorption from the gastrointestinal tract, entacapone is rapidly distributed to the peripheral tissues with a distribution volume of 20 litres at steady state (Vdss).
Slovenian: Po absorpciji iz prebavil se entakapon hitro porazdeli v periferna tkiva s porazdelitvenim volumnom 20 litrov v stanju dinamičnega ravnovesja (Vdss).
English: The post-marketing data include isolated cases of overdose in which the reported highest daily dose of entacapone has been 16,000 mg.
Slovenian: V postmarketinških podatkih so opisani primeri prevelikega odmerjanja, med katerimi je bil največji opisan dnevni odmerek entakapona 16.000 mg.
English: Entacapone (n=85) Placebo (n=86)
Slovenian: placebo (n=86)
English: Absorption There are large intra- and interindividual variations in the absorption of entacapone.
Slovenian: Absorpcija V absorpciji entakapona so velike intra- in interindividualne variacije.
English: It is a reversible, specific, and mainly peripherally acting COMT inhibitor designed for concomitant administration with levodopa preparations.
Slovenian: Je reverzibilen, specifičen in pretežno na periferiji delujoč zaviralec COMT, namenjen sočasni uporabi s pripravki levodope.
English: Data from in vitro studies using human liver microsomal preparations indicate that entacapone inhibits cytochrome P450 2C9 (IC50 ~4 μM).
Slovenian: Podatki iz študij in vitro na preparatih mikrosomov človeških jeter kažejo, da entakapon zavira citokrom P450 2C9 (IC50 ∼4 µM).
English: ** The incidence rates of myocardial infarction and other ischemic heart disease events (0.43% and 1.54%, respectively) are derived from an analysis of 13 double-blind studies involving 2082 patients with end-of-dose motor fluctuations receiving entacapone.
Slovenian: ** Pogostnost miokardnega infarkta (0,43 %) in drugih dogodkov v zvezi z ishemično boleznijo srca (1,54 %) temelji na rezultatih analize podatkov iz 13 dvojno slepih študij, v katere je bilo vključenih 2.082 bolnikov, ki so imeli motorična nihanja ob koncu delovanja odmerka in so prejemali entakapon.
English: Caution should be exercised when these medicinal products are used concomitantly with entacapone (see also sections 4.3 and 4.4).
Slovenian: Pri sočasni uporabi teh zdravil z entakaponom je potrebna previdnost (glejte tudi poglavji 4.3 in 4.4).
English: 305, 74770 Opava-Komarov Czech Republic
Slovenian: 305, 74770 Opava-Komarov
English: Some of the adverse reactions, such as dyskinesia, nausea, and abdominal pain, may be more common with the higher doses (1,400 to 2,000 mg per day) than with the lower doses of entacapone.
Slovenian: Nekateri neželeni učinki, kot so diskinezija, navzea in bolečine v trebuhu, so pri višjih odmerkih entakapona (1.400 do 2.000 mg dnevno) lahko pogostejši kot pri nižjih odmerkih.
English: Follow the instructions that your doctor has given you.
Slovenian: Upoštevajte zdravnikova navodila.
English: Consequently, adverse dopaminergic reactions may be more frequent when entacapone is added to levodopa/benserazide treatment (see also section 4.8).
Slovenian: Zato so lahko neželeni dopaminergični učinki pogostejši, kadar je entakapon dodan zdravljenju z levodopo/benserazidom (glejte tudi poglavje 4.8).
English: if you experience increasing loss of appetite, weakness, exhaustion and weight loss within a relatively short period of time, a general medical evaluation including liver function should be considered.
Slovenian: • če vedno bolj izgubljate apetit, če pride do oslabelosti, izčrpanosti in izgube telesne mase v razmeroma kratkem obdobju, je treba razmisliti o splošnem zdravniškem pregledu, vključno z oceno jetrne funkcije.
English: For the characteristics of NMS see Section 4 Possible side effects.
Slovenian: Za značilnosti NMS glejte poglavje 4 Možni neželeni učinki;
English: Dyskinesias (27%), nausea (11%), diarrhoea (8%), abdominal pain (7%) and dry mouth (4.2%) were reported significantly more often with entacapone than with placebo in pooled data from clinical studies involving 406 patients taking the medicinal product and 296 patients taking placebo.
Slovenian: Pri jemanju entakapona so bistveno pogosteje poročali o diskinezijah (27 %), navzei (11 %), driski (8 %), bolečinah v trebuhu (7 %) in suhih ustih (4,2 %) kot pri jemanju placeba po podatkih, združenih iz kliničnih študij s 406 bolniki, ki so jemali zdravilo, in 296 bolniki, ki so jemali placebo.
English: Very rare:
Slovenian: zelo redki:
English: If you forget to take the Entacapone Teva tablet with your levodopa dose, you should continue the treatment by taking the next Entacapone Teva tablet with your next levodopa dose.
Slovenian: Če pozabite vzeti tableto Entakapon Teva s svojim odmerkom levodope, nadaljujte zdravljenje tako, da vzamete naslednjo tableto Entakapon Teva z naslednjim odmerkom levodope.
English: The acute symptoms and signs in these cases of overdose included confusion, decreased activity, somnolence, hypotonia, skin discolouration and urticaria.
Slovenian: Pri teh primerih so akutni simptomi in znaki obsegali zmedenost, zmanjšano aktivnost, zaspanost, hipotonijo, obarvanost kože in urtikarijo.
English: Week 8-24 10.7±2.2
Slovenian: razlika izhodišče teden 8-24 10,7 ± 2,2
English: You may also use other medicines to treat Parkinson's disease at the same time.
Slovenian: Sočasno lahko jemljete tudi druga zdravila za zdravljenje Parkinsonove bolezni.
English: What Entacapone Teva is and what it is used for
Slovenian: Kaj je zdravilo Entakapon Teva in za kaj ga uporabljamo
English: Because of its mechanism of action, entacapone may interfere with the metabolism of medicinal products containing a catechol group and potentiate their action.
Slovenian: Zaradi svojega mehanizma delovanja lahko entakapon ovira presnovo zdravil, ki vsebujejo kateholno skupino, in povečuje njihove učinke.
English: In two phase III double-blind studies in a total of 376 patients with Parkinson's disease and end-ofdose motor fluctuations, entacapone or placebo was given with each levodopa/dopa decarboxylase inhibitor dose.
Slovenian: V dveh dvojno slepih študijah tretje faze, ki sta zajeli skupno 376 bolnikov s Parkinsonovo boleznijo in motoričnimi fluktuacijami na koncu delovanja odmerka, so bolniki dobivali entakapon ali placebo skupaj z vsakim odmerkom levodope/zaviralca DOPA-dekarboksilaze.
English: Entacapone is indicated as an adjunct to standard preparations of levodopa/benserazide or levodopa/carbidopa for use in adult patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.
Slovenian: Entakapon je indiciran kot dodatno zdravilo pri zdravljenju z običajnimi pripravki levodope/benserazida ali levodope/karbidope za uporabo pri odraslih bolnikih s Parkinsonovo boleznijo in motoričnimi nihanji ob koncu delovanja odmerka, ki jih ni mogoče stabilizirati z navedenimi kombinacijami.
English: If you are receiving dialysis for renal insufficiency, your doctor may tell you to increase the time between doses.
Slovenian: Če se zaradi insuficience ledvic zdravite z dializo, vam lahko zdravnik naroči, da podaljšate čas med dvema odmerkoma.
English: What you need to know before you take Entacapone Teva Do NOT take Entacapone Teva
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Entakapon Teva NE jemljite zdravila Entakapon Teva
English: Hence, to reduce levodopa-related dopaminergic adverse reactions, e.g. dyskinesias, nausea, vomiting and hallucinations, it is often necessary to adjust levodopa dosage within the first days to first weeks after initiating entacapone treatment.
Slovenian: Za zmanjšanje z levodopo povezanih dopaminergičnih neželenih učinkov, na primer diskinezij, navzee, bruhanja in halucinacij, je v prvih dneh do prvih tednih po začetku zdravljenja z entakaponom pogosto potrebno prilagoditi odmerjanje levodope.
English: Therefore, caution should be exercised when driving or using machines.
Slovenian: Zato je pri upravljanju motornih vozil in uporabi strojev potrebna previdnost.
English: When considered necessary, withdrawal of entacapone and other dopaminergic treatment should proceed slowly, and if signs and/or symptoms occur despite a slow withdrawal of entacapone, an increase in levodopa dosage may be necessary.
Slovenian: Kadar se ukinitev entakapona in drugih dopaminergičnih zdravil zdi potrebna, naj bo počasna in če se kljub počasnemu ukinjanju entakapona pojavijo znaki in/ali simptomi, je lahko potrebno zvečanje odmerjanja levodope.
English: For patients who experience progressive anorexia, asthenia and weight decrease within a relatively short period of time, a general medical evaluation including liver function should be considered.
Slovenian: Pri bolnikih, pri katerih pride do progresivne anoreksije, astenije in zmanjšanja telesne mase v razmeroma kratkem obdobju, je treba razmisliti o splošnem zdravniškem pregledu, vključno z oceno jetrne funkcije.
English: Entacapone thus prolongs the clinical response to levodopa.
Slovenian: Entakapon tako podaljša klinični odziv na levodopo.
English: Do not use Entacapone Teva during pregnancy or if you are breast-feeding.
Slovenian: Ne jemljite zdravila Entakapon Teva v nosečnosti ali če dojite.
English: In single-dose studies in healthy volunteers, no interactions were observed between entacapone and imipramine or between entacapone and moclobemide.
Slovenian: V študijah, v katerih so zdravi prostovoljci prejeli po en sam odmerek, niso opazili medsebojnega delovanja niti med entakaponom in imipraminom niti med entakaponom in moklobemidom.
English: - Neuroleptic Malignant Syndrome (NMS) is a rare severe reaction to medicines used to treat disorders of the nervous system.
Slovenian: • nevroleptični maligni sindrom (NMS) je redka huda reakcija na zdravila za zdravljenje centralnega živčnega sistema.
English: Renal insufficiency does not affect the pharmacokinetics of entacapone and there is no need for dose adjustment.
Slovenian: Ledvična insuficienca ne vpliva na farmakokinetiko entakapona, zato prilagajanje odmerka ni potrebno.
English: If entacapone treatment is discontinued, it is necessary to adjust the dosing of other antiparkinsonian treatments, especially levodopa, to achieve a sufficient level of control of the parkinsonian symptoms.
Slovenian: V primeru prekinitve zdravljenja z entakaponom je treba za doseganje zadostne ravni nadzora nad parkinsonskimi simptomi prilagoditi odmerjanje drugih antiparkinsonskih zdravil, zlasti levodope.
English: Due to its affinity to cytochrome P450 2C9 in vitro (see section 5.2), entacapone may potentially interfere with medicinal products with metabolism dependent on this isoenzyme, such as S-warfarin.
Slovenian: Zaradi svoje afinitete do citokroma P450 2C9 in vitro (glejte poglavje 5.2) lahko entakapon potencialno ovira presnovo zdravil, ki je odvisna od tega izoencima, na primer presnovo S-varfarina.
English: The maximum recommended dose is 200 mg ten times daily, i.e. 2,000 mg of entacapone.
Slovenian: Največji priporočeni odmerek je 200 mg desetkrat na dan, tj. 2.000 mg entakapona.
English: The (Z)-isomer and traces of other metabolites account for the remaining 5%.
Slovenian: Izomera (Z) in drugi presnovki v sledovih predstavljajo preostalih
English: Entacapone should be given cautiously to patients who are taking other medicinal products which may cause orthostatic hypotension.
Slovenian: Pri dajanju entakapona bolnikom, ki jemljejo druga zdravila, ki lahko povzročajo ortostatsko hipotenzijo, je potrebna previdnost.
English: Urine may be discoloured reddish-brown by entacapone, but this is a harmless phenomenon.
Slovenian: Entakapon lahko obarva urin rdečkastorjavo, vendar je ta pojav neškodljiv.
English: As Entacapone Teva tablets will be taken together with other levodopa medicines, please also read the package leaflets of these medicines carefully.
Slovenian: Ker boste tablete Entakapon Teva jemali skupaj z drugimi zdravili z levodopo, skrbno preberite tudi njihova navodila za uporabo.
English: In human plasma the unbound fraction is about 2.0% in the therapeutic concentration range.
Slovenian: V obsegu terapevtskih koncentracij je nevezana frakcija v človeški plazmi okrog 2,0 %.
English: Entacapone may, together with levodopa, cause dizziness and symptomatic orthostatism.
Slovenian: Entakapon lahko skupaj z levodopo povzroča omotičnost in simptomatski ortostatizem.