FrancophonIA/ELRC3.0 huggingface dataset:
English: If you stop using DuoTrav without speaking to your doctor the pressure in your eye will not be controlled, which could lead to loss of sight.
Croatian: Ako prestanete uzimati DuoTrav kapi bez da ste se posavjetovali sa liječnikom, tlak u Vašem oku neće biti pod kontrolom, što može dovesti do gubitka vida.
English: Existing data suggest that evening dosing might have some advantages as regards mean IOP reduction.
Croatian: Postojeći podaci sugeriraju da doziranje navečer može imati neke prednosti kod prosječnog sniženja IOT.
English: Package leaflet: Information for the user
Croatian: Uputa o lijeku: informacije za korisnika
English: Skin contact
Croatian: Kontakt s kožom
English: If you use more DuoTrav than you should
Croatian: Ako primijenite više DuoTrava nego što ste trebali
English: The two substances work together to reduce pressure within the eye.
Croatian: Ova dva sastojka zajedno snižavaju tlak u oku.
English: This helps to stop DuoTrav getting into the rest of the body.
Croatian: Tako ćete spriječiti da DuoTrav prijeđe u ostatak tijela.
English: DuoTrav eye drops are used to treat high pressure in the eye in adults, including the elderly.
Croatian: DuoTrav kapi za oko se koriste za liječenje visokog tlaka u oku kod odraslih osoba, uključujući starije.
English: What DuoTrav is and what it is used for
Croatian: Što je DuoTrav i za što se koristi
English: Talk to your doctor before using DuoTrav if you have now or have had in the past
Croatian: Obratite se svom liječniku prije nego primijenite DuoTrav ako imate ili ste imali u prošlosti:
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako primjenjujete, nedavno ste primijenili ili biste mogli primijeniti bilo koje druge lijekove, uključujući i one koji se izdaju bez recepta.
English: Unilateral treatment can result in permanent heterochromia.
Croatian: Monookularno liječenje može dovesti do trajne heterokromije.
English: Pull your lower eyelid down with a clean finger until there is a “pocket”
Croatian: Donju vjeđu lagano povucite prema dolje s čistim prstom dok ne nastane „džep“ između vjeđa i oka.
English: The use of two local prostaglandins is not recommended.
Croatian: Ne preporučuje se lokalna primjena dva prostaglandina.
English: Travoprost may gradually change the eye colour by increasing the number of melanosomes (pigment granules) in melanocytes.
Croatian: Travoprost može postupno promijeniti boju očiju povećanjem broja melanosoma (pigmentna zrnca) u melanocitima.
English: If you need to have any type of surgery, tell your doctor that you are using DuoTrav as timolol may change the effects of some medicines used during anaesthesia.
Croatian: Ako trebate imati bilo koju vrstu operacije, obavijestite Vašeg liječnika da primjenjujete DuoTrav jer timolol može promijeniti učinak nekih lijekova koji se koriste tijekom anestezije.
English: Reduction of IOP in man starts within approximately 2 hours after administration and maximum effect is reached after 12 hours.
Croatian: Sniženje IOT kod čovjeka počinje kroz približno 2 sata nakon ukapavanja i maksimalni učinak se dosegne nakon 12 sati.
English: Travoprost has harmful pharmacological effects on pregnancy and/or the foetus/newborn child.
Croatian: Travoprost ima štetan farmakološki učinak na trudnoću i/ili fetus/novorođenče.
English: Before treatment is instituted, patients must be informed of the possibility of a permanent change in eye colour.
Croatian: Prije početka liječenja potrebno je upozoriti bolesnika na mogućnost trajne promjene boje oka.
English: The long-term effects on the melanocytes and any consequences thereof are currently unknown.
Croatian: Dugotrajni učinci na melanocite i bilo koja posljedica u svezi s tim trenutno nije poznata.
English: Hypersensitivity to other beta blockers.
Croatian: Preosjetljivost na druge beta blokatore.
English: • myasthenia gravis (chronic neuromuscular weakness).
Croatian: • mijastenija gravis (kronična neuromišićna slabost).
English: Other medicines and DuoTrav
Croatian: Drugi lijekovi i DuoTrav
English: Date of first authorisation: 24 April 2006 Date of last renewal: 07 October 2010
Croatian: Date posljednje obnove odobrenja: 07. listopada 2010.
English: These two components lower intraocular pressure by complementary mechanisms of action and the combined effect results in additional IOP reduction compared to either compound alone.
Croatian: Ova dva sastojka snižavaju intraokularni tlak komplementarnim mehanizmima djelovanja i kombinirani učinak je dodatno sniženje IOT u usporedbi sa svakim sastojkom pojedinačno.
English: Travoprost may be absorbed through the skin and therefore should not be used by women who are pregnant or are attempting to become pregnant.
Croatian: Travoprost se lako apsorbira kroz kožu, te ga ne smiju koristiti trudnice, niti žene koje planiraju trudnoću.
English: The drop will go in here (picture 2).
Croatian: Tu ukapajte kap (slika 2).
English: If any of the medicine comes into contact with the skin then it should be washed off straight away.
Croatian: Ako lijek dođe u dodir s kožom, morate ga odmah isprati.
English: This may result in a decrease in systemic side effects and an increase in local activity (see section 4.4).
Croatian: To može smanjiti sustavne nuspojave i povećati lokalnu aktivnost (vidjeti dio 4.4).
English: You can usually carry on using the drops, unless the effects are serious.
Croatian: Obično možete nastaviti s primjenom kapi, osim u slučaju pojave ozbiljnih nuspojava.
English: Timolol is metabolised by two pathways.
Croatian: Timolol se metabolizira na dva načina.
English: Non-clinical data revealed no special hazard for humans with timolol based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential.
Croatian: Neklinički podaci za timolol ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti i kancerogenog potencijala.
English: For information on how to reduce systemic absorption, see section 4.2.
Croatian: Za informaciju kako smanjiti sustavnu apsorpciju, vidjeti dio 4.2.
English: Women who are pregnant or attempting to become pregnant should exercise appropriate precautions to avoid direct exposure to the contents of the bottle.
Croatian: Žene koje su trudne ili očekuju trudnoću, moraju obratiti pozornost na potrebne mjere opreza da spriječe izravan dodir sa sadržajem bočice.
English: Pack sizes of 1, 3 or 6 bottles.
Croatian: Veličine pakiranja od 1, 3 ili 6 bočica.
English: If DuoTrav is administered until delivery, the neonate should be carefully monitored during the first days of life.
Croatian: Ukoliko se DuoTrav primjenjuje do poroda, novorođenče mora biti pažljivo praćeno tijekom prvih dana života.
English: The anaesthetist should be informed when the patient is receiving timolol.
Croatian: Anesteziolog mora biti informiran kada bolesnik prima timolol.
English: If you could get pregnant you must use adequate contraception whilst you use the medicine.
Croatian: Ako postoji mogućnost da ostanete trudni, morate koristiti adekvatnu kontracepciju za vrijeme terapije ovim lijekom.
English: Insufficient responsiveness to monotherapy was not an inclusion criterion.
Croatian: Nezadovoljavajući odgovor na monoterapiju nije bio uključujući kriterij.
English: When measurable (0.01 ng/mL, the assay limit of quantitation), concentrations ranged from 0.01 to 0.03 ng/mL.
Croatian: Kad je bila mjerljiva (≥0,01ng/ml, granica testa mjerenja), koncentracija je bila u rasponu od 0,01 do 0,03 ng/ml.
English: Less than 2% of an ocular dose of travoprost was recovered in urine as free acid.
Croatian: Manje od 2% jedne doze za oko travoprosta nađeno je u urinu kao slobodna kiselina.
English: Inclusion criteria were common across the studies, with the exception of the IOP entry criteria and response to previous IOP therapy.
Croatian: Kriteriji uključenja bili su isti kroz studije, s izuzetkom kriterija ulaznog IOT i odgovora na prethodnu antiglaukomsku terapiju.
English: What DuoTrav is and what it is used for What you need to know before you use DuoTrav How to use DuoTrav
Croatian: Što je DuoTrav i za što se koristi Što morate znati prije nego počnete primjenjivati DuoTrav Kako primjenjivati DuoTrav
English: Blood pressure diastolic decreased, blood pressure systolic increased
Croatian: Sniženi dijastolički krvni tlak, povišeni sistolički krvni tlak
English: Other beta-blocking agents
Croatian: Ostali beta blokatori
English: Prostaglandins and prostaglandin analogues are biologically active substances that may be absorbed through the skin.
Croatian: Prostaglandini i analozi prostaglandina su biološki aktivne tvari te se mogu apsorbirati kroz kožu.
English: • if you are allergic to travoprost, prostaglandins, timolol, beta blockers or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični na travoprost, prostaglandin, timolol, beta blokatore ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Reproduction toxicity studies with travoprost have been undertaken in rats, mice and rabbits using the systemic route.
Croatian: Studije reprodukcijske toksičnosti travoprosta provedene su u štakora, miševa i kunića koristeći sustavni put.
English: Hypersensitivity to the active substances, or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivost na djelatne tvari ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: Approximately 20% of a timolol dose is excreted in the urine unchanged and the remainder excreted in urine as metabolites.
Croatian: Približno 20% doze timolola se izlučuje nepromijenjeno u mokraći, a ostatak se izlučuje u mokraći kao metaboliti.
English: If you get any severe allergic reaction (skin rash, redness and itching of the eye) while using DuoTrav, whatever the cause, adrenaline treatment may not be as effective.
Croatian: Ako dobijete bilo koju tešku alergijsku reakciju (osip kože, crvenilo i svrbež oka) za vrijeme primjene DuoTrava, bez obzira na uzrok, adrenalinska terapija možda neće biti jednako učinkovita.
English: Effects in the eye
Croatian: Učinci na oko
English: DuoTrav has no or negligible influence on the ability to drive and use machines.
Croatian: DuoTrav ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Timolol may interact with other medicinal products (see section 4.5).
Croatian: Timolol može stupiti u interakciju s drugim lijekovima (vidjeti dio 4.5).
English: Children DuoTrav is not to be used by children and adolescents under 18 years of age.
Croatian: Djeca DuoTrav kapi nisu za primjenu kod djece i adolescenata ispod 18 godina starosti.
English: • Immediately before using a bottle for the first time, tear open the overwrap (picture 1), remove the bottle and write the date of opening on the label in the space provided.
Croatian: • Zaštitni omot rastvorite neposredno prije prve primjene (slika 1), izvadite bočicu i zapišite datum otvaranja na naljepnici bočice na označenom mjestu.
English: EXP Discard 4 weeks after first opening.
Croatian: EXP Odbacite 4 tjedna nakon prvog otvaranja.
English: Dysuria, urinary incontinence
Croatian: Dizurija, urinarna inkontinencija
English: Within each frequency grouping, adverse reactions are presented in decreasing order of seriousness.
Croatian: Unutar svake grupe učestalosti, nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
English: Tiny amounts of sodium hydroxide or hydrochloric acid are added to keep acidity levels (pH levels) normal.
Croatian: Male količine natrijevog hidroksida i kloridne kiseline dodane su za održavanje normalne razine kiselosti (pH vrijednosti).
English: What you need to know before you use DuoTrav
Croatian: Što morate znati prije nego počnete primjenjivati DuoTrav
English: Topical ocular administration of travoprost to monkeys at concentrations of up to 0.012% to the right eye, twice daily for one year resulted in no systemic toxicity.
Croatian: Lokalna primjena travoprosta u desno oko majmuna koncentraciji do 0,012%, dvaput dnevno kroz jednu godinu nije prouzročila nikakve sustavne toksičnosti.
English: Each time you start a new bottle write down the date you open it in the spaces on the bottle label and carton.
Croatian: Svaki put počnite s novom bočicom, zapišite datum otvaranja na za to predviđeno mjesto na naljepnici bočice i na kutiji.
English: Beta blockers can mask the signs and symptoms of hypoglycaemia (see section 4.4).
Croatian: Beta blokatori mogu prikriti znakove i simptome hipoglikemije (vidjeti dio 4.4).
English: Metabolism is the major route of elimination of both travoprost and the active free acid.
Croatian: Metabolizam je glavni put eliminacije travoprosta i aktivne slobodne kiseline.
English: Do not put in any more drops until it is time for your next regular dose.
Croatian: Ponovno ukapajte tek kad bude vrijeme za sljedeću dozu.
English: The recommended dose is one drop in the affected eye or eyes once a day in the morning or in the evening.
Croatian: Preporučena doza je jedna kap u oko (oči) koje se liječi, jednom dnevno-ujutro ili navečer.
English: To prevent contamination of the dropper tip and solution, care must be taken not to touch the eyelids, surrounding areas or other surfaces with the dropper tip of the bottle.
Croatian: Radi prevencije kontaminacije vrha kapaljke i otopine, mora se paziti da se ne dotaknu vjeđe, okolna područja ili druge površine vrhom kapaljke bočice.
English: If you use more DuoTrav than you should, rinse it all out with warm water.
Croatian: Ako primijenite više DuoTrava nego što ste trebali, isperite oko mlakom vodom.
English: The patient should remove the protective overwrap immediately prior to initial use.
Croatian: Bolesnik mora ukloniti zaštitni omot (vrećicu) neposredno prije prve primjene.
English: Do not use DuoTrav if you are pregnant unless your doctor considers it necessary.
Croatian: Ne koristite DuoTrav ako ste trudni osim u slučaju da to Vaš liječnik smatra potrebnim.
English: When nasolacrimal occlusion is used or the eyelids are closed for 2 minutes, systemic absorption is reduced.
Croatian: Kad se nazolakrimalna okluzija primjenjuje ili vjeđe zatvore na 2 minute, smanjuje se sustavna apsorpcija.
English: Metabolism: low blood sugar levels, increase in prostate cancer marker.
Croatian: Metabolizam: niska razina šećera u krvi, povišene vrijednosti tumorskih markera prostate.
English: Sexual dysfunction, decreased libido
Croatian: Spolna disfunkcija, smanjen libido
English: Ask your doctor for advice if any of these applies to you.
Croatian: Potražite savjet liječnika ako se nešto od gore navedenog odnosi na Vas.
English: DuoTrav may get into your milk.
Croatian: DuoTrav može prijeći u majčino mlijeko.
English: If overdose with DuoTrav occurs, treatment should be symptomatic and supportive.
Croatian: U slučaju predoziranja sa DuoTravom liječenje mora biti simptomatsko i suportivno.
English: Timolol does not dialyse readily.
Croatian: Timolol se ne dijalizira lako.
English: Due to their negative effect on conduction time, beta blockers should only be given with caution to patients with first-degree heart block.
Croatian: Zbog njihovog negativnog učinka na vrijeme provođenje, beta blokatori se moraju s oprezom primjenjivati kod bolesnika sa srčanim blokom prvog stupnja.
English: DuoTrav should be used with caution in patients with mild/moderate chronic obstructive pulmonary disease (COPD) and only if the potential benefit outweighs the potential risk.
Croatian: DuoTrav se mora primijeniti s oprezom kod bolesnika s blagom/umjerenom kroničnom opstruktivnom plućnom bolesti (KOPB) i samo u slučaju da potencijalna korist nadmašuje mogući rizik.
English: The effect on intra-ocular pressure or the known effects of systemic beta blockade may be potentiated when timolol is given to patients already receiving a systemic beta-blocking medicinal product.
Croatian: Učinak na intraokularni tlak ili poznati učinci sistemske beta blokade mogu biti pojačani kada se timolol daje bolesnicima koji već primaju sistemski beta blokator.
English: Reproduction: sexual dysfunction, decreased libido.
Croatian: Reprodukcija: spolna disfunkcija, oslabljen libido.
English: • disturbances of heart rate such as slow heartbeat.
Croatian: • smetnje srčanog pulsa kao što su usporeni otkucaji srca.
English: However, at therapeutic doses of timolol in eye drops it is not likely that sufficient amounts would be present in breast milk to produce clinical symptoms of beta blockade in the infant.
Croatian: Ipak, kod terapijskih doza timolola u kapima za oko ne očekuje se pojava dovoljne količine u majčinom mlijeku koja bi uzrokovala kliničke simpotme beta blokade kod dojenčeta.
English: Patients with severe peripheral circulatory disturbance/disorders (i.e. severe forms of Raynaud's disease or Raynaud's syndrome) should be treated with caution.
Croatian: Bolesnike s teškim poremećajima/bolestima periferne cirkulacije (npr. teški oblici Raynaudove bolesti ili Raynaudova sindroma) mora se liječiti s oprezom.
English: DuoTrav must not be used in women of child-bearing age/potential unless adequate contraceptive measures are in place (see section 5.3).
Croatian: DuoTrav ne smiju koristiti žene reproduktivne dobi/potencijala, osim ako nisu poduzete adekvatne mjere kontracepcije (vidjeti dio 5.3)
English: Timolol is a non-selective adrenergic blocking agent that has no intrinsic sympathomimetic, direct myocardial depressant or membrane-stabilising activity.
Croatian: Timolol je neselektivni beta adrenergički blokator koji nema unutarnju simpatomimetičku, direktnu miokardijalno depresivnu aktivnost niti aktivnost stabilizacije membrana.
English: In pregnant rats, systemic administration of travoprost at doses more than 200 times the clinical dose during the period of organogenesis resulted in an increased incidence of malformations.
Croatian: U trudnih štakorica, sustavna primjena travoprosta u dozama većim od 200 puta od kliničke doze tijekom razdoblje organogeneze, prouzrokuje povećanu incidenciju malformacija.
English: • Gently squeeze the bottle to release one drop of DuoTrav at a time (picture 3).
Croatian: • Lagano stisnite bočicu, tako da isteče po jedna kap lijeka DuoTrav (slika 3).
English: Animal studies have shown excretion of travoprost and metabolites in breast milk.
Croatian: Ispitivanja na životinjama su pokazale izlučivanje travoprosta i metabolita u mlijeko.
English: If you are using other eye drops in addition to DuoTrav, leave at least 5 minutes between applying DuoTrav and the other drops.
Croatian: Ako istodobno koristite druge kapi za oči uz DuoTrav, pričekajte najmanje 5 minuta između primjene DuoTrav kapi i ostalih kapi za oko.
English: Nervous system and general disorders: difficulty sleeping (insomnia), nightmares, memory loss, loss of strength and energy, anxiety (excessive emotional distress).
Croatian: Živčani sustav i opći poremećaji: poteškoće sa spavanjem (nesanica), noćne more, gubitak pamćenja, gubitak snage i energije, anksioznost (pretjerano emocionalno nezadovoljstvo).
English: As with any eye drops, temporary blurred vision or other visual disturbances may occur.
Croatian: Kao i kod drugih kapi za oko, mogu se pojaviti prolazno zamućenje vida ili drugi vidni poremećaji.
English: Patients with cardiovascular diseases should be watched for signs of deterioration of these diseases and of adverse reactions.
Croatian: Bolesnici sa srčanim bolestima moraju biti pod nadzorom zbog znakova pogoršanja ovih bolesti ili pojave nuspojava.
English: • poor blood circulation disease (such as Raynaud's disease or Raynaud's syndrome).
Croatian: • poremećaj krvotoka (kao što je Raynaudova bolest ili Raynaudov sindrom).
English: There are no data on the effects of DuoTrav on human fertility.
Croatian: Nema podataka o učinku DuoTrav kapi na plodnost kod čovjeka.
English: Insomnia, nightmares, memory loss
Croatian: Nesanica, noćne more, gubitak pamćenja
English: Tell your doctor if you are using or intend to use medicines to lower blood pressure, heart medicines including quinidine (used to treat heart conditions and some types of malaria), medicines to treat diabetes or the antidepressants fluoxetine or paroxetine.
Croatian: Obavijestite svog liječnika ako koristite, ili ćete koristiti, lijekove za snižavanje krvnog tlaka, lijekove za srce uključujući kinidin (koristi se za liječenje srčanih stanja i nekih tipova malarije), lijekove za liječenje dijabetesa ili antidepresive fluoksetin ili paroksetin.
English: • if you have now or have had in the past respiratory problems such as asthma, severe chronic obstructive bronchitis (severe lung disease which may cause wheeziness, difficulty in breathing and/or long-standing cough), or other types of breathing problems.
Croatian: • ako imate ili ste u prošlosti imali dišne tegobe, kao što je astma, teški kronični opstruktivni bronhitis (tešku bolest pluća koje može uzrokovati piskanje pri disanju, otežano disanje i/ili dugotrajni kašalj) ili druge teškoće s disanjem.
English: Travoprost significantly increased optic nerve head blood flow in rabbits following 7 days of topical ocular administration (1.4 micrograms once daily).
Croatian: Travoprost je značajno povećao protok krvi u glavi očnog živca u kunića nakon 7 dana lokalne primjene u oko (1,4 mikrograma, jednom dnevno).
English: • if you have a slow heartbeat, heart failure or a disorder of heart rhythm (irregular heartbeat).
Croatian: • ako imate usporene otkucaje srca, srčano zatajenje ili poremećaj srčanog ritma (nepravilni otkucaji srca).
English: Reproduction and development studies have demonstrated a potent effect on foetal loss with a high rate observed in rats and mice (180 pg/mL and 30 pg/mL plasma, respectively) at exposures 1.2 to 6 times the clinical exposure (up to 25 pg/mL).
Croatian: Reprodukcijske i razvojne studije pokazale su snažan učinak na gubitak ploda s visokom stopom zabilježenom u štakora i miševa (180 pg/ml, odnosno 30pg/ml plazme) pri izloženostima 1,2 do 6 puta većima od kliničke izloženosti (do 25 pg/ml)
English: A topical overdose with DuoTrav is not likely to occur or to be associated with toxicity.
Croatian: Lokalno predoziranje DuoTravom nije očekivano niti povezano s toksičnošću.
English: Additional adverse reactions that have been seen with one of the active substances and may potentially occur with DuoTrav:
Croatian: Dodatne nuspojave koje su zabilježene s jednom od djelatnih tvari, a moguća je njihova pojava s DuoTrav kapima:
English: Cerebral ischaemia, increases in signs and symptoms of myasthenia gravis
Croatian: Cerebralna ishemija, pojačani znakovi i simptomi miastenije gravis
English: The use of two topical beta-adrenergic blocking agents is not recommended (see section 4.5).
Croatian: Lokalna primjena dva beta adrenergička blokatora nije preporučena (vidjeti 4.5).
English: Findings are related to FP receptor agonist activity in uterus with early embryolethality, post-implantation loss and foetotoxicity.
Croatian: Nalazi su povezani s agonističkom aktivnosti na FP receptore u maternici sa ranom smrtnošću embrija, gubitkom nakon implantacije i fetotoksičnošću.
English: DuoTrav may change the colour of your iris (the coloured part of your eye).
Croatian: DuoTrav može promijeniti boju šarenice (obojeni dio Vašeg oka).
English: Animal studies showed no effect of travoprost on fertility at doses up to 75 times the maximum recommended human ocular dose, whereas no relevant effect of timolol was noted at this dose level.
Croatian: Ispitivanja na životinjama pokazala su da nema učinka na plodnost kod primjene travoprosta u dozama do 75 puta većim od maksimalno preporučene doze za primjenu u oko kod ljudi, dok nije primijećen nikakav značajan učinak timolola pri ovim dozama.
English: When substituting another ophthalmic antiglaucoma medicinal product with DuoTrav, the other medicinal product should be discontinued and DuoTrav should be started the following day.
Croatian: Kada se drugi lokalni antiglaukomski lijek zamjenjuje DuoTravom, mora se prekinuti primjena drugog lijeka i započeti s primjenom DuoTrava sljedećeg dana.