FrancophonIA/ELRC3.0 huggingface dataset:
English: The inhibition of acid secretion is related to the area under the plasma concentration-time curve (AUC) of omeprazole and not to the actual plasma concentration at a given time.
Slovenian: Zavrtje izločanja kisline je povezano s površino pod krivuljo plazemske koncentracije omeprazola po času (AUC) in ne z dejansko koncentracijo v plazmi ob določenem času.
English: your doctor may also prescribe antibiotics to treat the infection and allow the ulcer to heal.
Slovenian: mu bo zdravnik morda predpisal tudi antibiotike za zdravljenje okužbe in zacelitev razjede.
English: • You experience severe or persistent diarrhoea, as omeprazole has been associated with a small increase in infectious diarrhoea.
Slovenian: • Če se vam pojavi huda ali dolgotrajna driska, kajti omeprazol je bil povezan z nekoliko večjo pogostnostjo infekcijske driske.
English: If affected, you should not drive or operate machinery.
Slovenian: Če se vam to zgodi, ne smete voziti ali upravljati s stroji.
English: • The medicine will be given to you as an infusion into one of your veins.
Slovenian: • Zdravilo boste dobili kot infuzijo v eno od ven.
English: • In combination with appropriate antibiotics, Helicobacter pylori (H. pylori) eradication in peptic ulcer disease
Slovenian: • v kombinaciji z ustreznimi antibiotiki za odpravo Helicobacter pylori (H. pylori) pri peptični ulkusni bolezni
English: Elderly The metabolism rate of omeprazole is somewhat reduced in elderly subjects (75-79 years of age).
Slovenian: Starejši Hitrost presnove omeprazola je pri starejših osebah (od 75 do 79 let) nekoliko manjša.
English: • Ulcers which are infected with bacteria called ‘Helicobacter pylori'.
Slovenian: • Razjed, okuženih z bakterijo, ki se imenuje Helicobacter pylori.
English: A reinforced monitoring of tacrolimus concentrations as well as renal function (creatinine clearance) should be performed, and dosage of tacrolimus adjusted if needed.
Slovenian: Intenzivneje je treba kontrolirati koncentracijo takrolimusa in delovanje ledvic (očistek kreatinina), odmerek takrolimusa pa prilagoditi, če je treba.
English: This may cause you symptoms such as a painful burning sensation in the chest rising up to the throat (heartburn) and a sour taste in the mouth (acid regurgitation).
Slovenian: To lahko povzroči simptome, npr. boleč pekoč občutek v prsih, ki se dviga proti žrelu (zgaga) in kisel okus v ustih (regurgitacija kisline).
English: With a syringe draw 5 ml of infusion solution from the 100 ml infusion bottle or bag.
Slovenian: Z brizgo potegnite 5 ml raztopine za infundiranje iz 100-ml infuzijske stekleničke ali vrečke.
English: For the eradication of H. pylori the selection of antibiotics should consider the individual patient's drug tolerance, and should be undertaken in accordance with national, regional and local resistance patterns and treatment guidelines.
Slovenian: Za odpravo H. pylori je treba pri izbiri antibiotikov upoštevati prenašanje zdravil pri posameznem bolniku, zdravljenje pa mora upoštevati nacionalne, regionalne in lokalne značilnosti glede odpornosti ter smernice za zdravljenje.
English: The absorption of posaconazole, erlotinib, ketoconazol and itraconazol is significantly reduced and thus clinical efficacy may be impaired.
Slovenian: Absorpcija posakonazola, erlotiniba, ketokonazola in itrakonazola se bistveno zmanjša in to lahko poslabša klinično učinkovitost.
English: Detailed information on this product is available on the website of: {name of MS/Agency} [To be completed nationally]
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani: {Ime DČ/Agencije} [Izpolni država članica]
English: What to do if you or your child have trouble swallowing the tablets
Slovenian: Kaj storiti, če vi ali vaš otrok težko pogoltneta tablete
English: If you have an infection with symptoms such as fever with a severely reduced general condition or fever with symptoms of a local infection such as pain in the neck, throat or mouth or difficulties in urinating, you must consult your doctor as soon as possible so that a lack of white blood cells (agranulocytosis) can be ruled out by a blood test.
Slovenian: Če imate okužbo s simptomi, kot sta npr. zvišana telesna temperatura in zelo slabo splošno stanje, ali zvišana telesna temperatura s simptomi lokalne okužbe, npr. bolečinami v vratu, žrelu ali ustih, ali s težavami pri uriniranju, se morate čim prej posvetovati z zdravnikom, da bo lahko s preiskavo krvi izključil pomanjkanje belih krvnih celic (agranulocitozo).
English: Omeprazole and omeprazole magnesium are acid labile and are therefore administered orally as enteric-coated granules in capsules or tablets.
Slovenian: Omeprazol in magnezijev omeprazolat sta kislinsko labilna, zato se peroralno uporabljata v gastrorezistentnih zrncih v kapsulah ali tabletah.
English: Monitoring phenytoin plasma concentration is recommended during the first two weeks after initiating omeprazole treatment and, if a phenytoin dose adjustment is made, monitoring and a further dose adjustment should occur upon ending omeprazole treatment.
Slovenian: Koncentracijo fenitoina v plazmi je priporočljivo kontrolirati prva dva tedna po začetku zdravljenja z omeprazolom; če je narejena prilagoditev odmerka fenitoina, je treba kontrolo in nadaljnjo prilagoditev odmerka narediti po koncu zdravljenja z omeprazolom.
English: Transfer the solution into the infusion bag or bottle.
Slovenian: Prenesite raztopino v infuzijsko vrečko ali stekleničko.
English: The remaining part is dependent on another specific isoform, CYP3A4, responsible for the formation of omeprazole sulphone.
Slovenian: Preostali del je odvisen od druge specifične izooblike, CYP3A4; ta je odgovorna za nastanek omeprazolsulfona.
English: • Your doctor will also prescribe two antibiotics called amoxicillin and clarithromycin for your child.
Slovenian: • Zdravnik bo otroku predpisal tudi dva antibiotika, ki se imenujeta amoksicilin in klaritromicin.
English: Children and adolescents over 4 years of age • In combination with antibiotics in treatment of duodenal ulcer caused by H. pylori
Slovenian: Otroci in mladostniki, starejši od 4 let • v kombinaciji z antibiotiki za zdravljenje razjede na dvanajstniku, ki jo povzroča H. pylori
English: If you do not experience relief, or if you experience a worsening of symptoms, consult your doctor.
Slovenian: Če se vam stanje ne izboljša ali če se vam simptomi poslabšajo, se posvetujte z zdravnikom.
English: The symptoms described in connection to omeprazole overdose have been transient, and no serious outcome has been reported.
Slovenian: Simptomi, opisani v povezavi s prevelikim odmerjanjem omeprazola, so bili prehodni in poročali niso o nobenem resnem izidu.
English: Chemical and physical in-use stability has been demonstrated for 4 hours at 25oC after reconstitution.
Slovenian: Kemična in fizikalna stabilnost med uporabo sta bili dokazani za 4 ure po pripravi (rekonstituciji) pri temperaturi 25 °C.
English: The pharmacokinetics of omeprazole, including systemic bioavailability and elimination rate, are unchanged in patients with reduced renal function.
Slovenian: Farmakokinetika omeprazola, vključno s sistemsko biološko uporabnostjo in hitrostjo odstranjevanja, pri bolnikih z zmanjšanim delovanjem ledvic ni spremenjena.
English: • Eyesight problems such as blurred vision.
Slovenian: • težave z vidom, npr. zamegljen vid
English: In addition, omeprazole lacks an inhibitory effect on the main CYP enzymes.
Slovenian: Poleg tega omeprazol ne zavira glavnih encimov CYP.
English: If your doctor has prescribed the antibiotics amoxicillin and clarithromycin as well as Losec to treat ulcers caused by Helicobacter pylori infection, it is very important that you tell your doctor about any other medicines you are taking.
Slovenian: Če vam je zdravnik poleg zdravila Losec za zdravljenje razjed, ki jih povzroča okužba s Helicobacter pylori, predpisal tudi antibiotika amoksicilin in klaritromicin, je zelo pomembno, da mu poveste za vsa druga zdravila, ki jih morda jemljete.
English: • Diazepam (used to treat anxiety, relax muscles or in epilepsy).
Slovenian: • diazepam (uporablja se za zdravljenje tesnobnosti, za sproščanje mišic ali pri epilepsiji).
English: The major part of its metabolism is dependent on the polymorphically expressed CYP2C19, responsible for the formation of hydroxyomeprazole, the major metabolite in plasma.
Slovenian: Glavni del njegove presnove je odvisen od polimorfno izraženega CYP2C19; ta je odgovoren za nastanek hidroksiomeprazola, glavnega presnovka v plazmi.
English: • Losec will be given to you by a doctor who will decide how much you need.
Slovenian: • Zdravilo Losec vam bo dal zdravnik, ki bo tudi odločil, koliko zdravila potrebujete.
English: In such individuals the metabolism of omeprazole is probably mainly catalysed by CYP3A4.
Slovenian: Pri takšnih osebah presnovo omeprazola verjetno v glavnem katalizira CYP3A4.
English: Absorption of omeprazole is rapid, with peak plasma levels occurring approximately 1-2 hours after dose.
Slovenian: Absorpcija omeprazola je hitra, največjo koncentracijo v plazmi pa doseže približno 1 do 2 uri po odmerku.
English: In order to immediately achieve a similar reduction of intragastric acidity as after repeated dosing with 20 mg orally, a first dose of 40 mg intravenously is recommended.
Slovenian: Da bi takoj dosegli podobno zmanjšanje želodčne kislosti, kot je doseženo po večkratnem odmerjanju 20 mg peroralno, je priporočeni prvi odmerek 40 mg intravensko.
English: Pharmacodynamic effects All pharmacodynamic effects observed can be explained by the effect of omeprazole on acid secretion.
Slovenian: Farmakodinamični učinki Vse opažene farmakodinamične učinke je mogoče pojasniti z učinkom omeprazola na izločanje kisline.
English: Symptomatic treatment of heartburn and acid regurgitation in gastro-esophageal reflux disease: The treatment time is 2-4 weeks.
Slovenian: Simptomatsko zdravljenje zgage in regurgitacije kisline pri gastroezofagealni refluksni bolezni: Trajanje zdravljenja je od 2 do 4 tedne.
English: Intravenous doses of up to 270 mg on a single day and up to 650 mg over a three-day period have been given in clinical trials without any dose-related adverse reactions.
Slovenian: V kliničnih preskušanjih so bili uporabljeni intravenski odmerki do 270 mg na posamezen dan in do 650 mg v tridnevnem obdobju, ne da bi se pojavili z odmerkom povezani neželeni učinki.
English: However, dose adjustment should be considered in patients with severe hepatic impairment and if long-term treatment is indicated.
Slovenian: Pride pa prilagoditev v poštev pri bolnikih s hudo okvaro jeter ali če je indicirano dolgotrajno zdravljenje.
English: It belongs to a group of medicines called ‘proton pump inhibitors'.
Slovenian: Spada v skupino zdravil, imenovanih "zaviralci protonske črpalke".
English: In another study it was shown that administering clopidogrel and omeprazole at different times did not prevent their interaction that is likely to be driven by the inhibitory effect of omeprazole on CYP2C19.
Slovenian: Druga študija je pokazala, da uporaba klopidogrela in omeprazola ob različnem času ne prepreči njunega medsebojnega delovanja, ki je verjetno posledica zavrtja CYP2C19 z omeprazolom.
English: These changes are the result of sustained hypergastrinaemia secondary to acid inhibition.
Slovenian: Te spremembe so posledica trajne hipergastrinemije zaradi zavrtja kisline.
English: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN) Musculoskeletal and connective tissue disorders Rare:
Slovenian: multiformni eritem, Stevens-Johnsonov sindrom, toksična epidermalna nekroliza (TEN) Bolezni mišično-skeletnega sistema in vezivnega tkiva Redki:
English: This results in an immediate decrease in intragastric acidity and a mean decrease over 24 hours of approximately 90% for both iv injection and iv infusion.
Slovenian: To povzroči takojšnje zmanjšanje želodčne kislosti in povprečno 90 % 24-urno zmanjšanje tako po intravenski injekciji kot intravenski infuziji.
English: It might be necessary to take the tablets for 2-3 consecutive days to achieve improvement of symptoms.
Slovenian: Za izboljšanje simptomov je lahko potrebno jemanje teh tablet 2 ali 3 dni zapored.
English: In a non-controlled study in children (1 to 16 years of age) with severe reflux esophagitis, omeprazole at doses of 0.7 to 1.4 mg/kg improved esophagitis level in 90% of the cases and significantly reduced reflux symptoms.
Slovenian: V nekontrolirani študiji pri otrocih (starih od 1 do 16 let) s hudim refluksnim ezofagitisom je omeprazol v odmerkih od 0,7 do 1,4 mg/kg izboljšal stopnjo ezofagitisa v 90 % primerov ter je bistveno zmanjšal simptome refluksa.
English: • Digoxin (used to treat heart problems)
Slovenian: • digoksin (uporablja se za zdravljenje težav s srcem).
English: In case of therapy failure, the dose can be increased to 40 mg.
Slovenian: Če zdravljenje ni uspešno, je mogoče odmerek povečati na 40 mg.
English: This medicinal product is authorised in the Member States of the EEA under the following names: [See Annex I - To be completed nationally]
Slovenian: To zdravilo je odobreno v državah članicah EGP pod naslednjimi imeni: [Glejte Dodatek I - izpolni država članica]
English: In children, the symptoms of the condition can include the return of stomach contents into the mouth (regurgitation), being sick (vomiting) and poor weight gain.
Slovenian: Pri otrocih so lahko med simptomi te bolezni vračanje želodčne vsebine v usta (regurgitacija), bruhanje in slabo pridobivanje telesne mase.
English: These changes are a physiological consequence of pronounced inhibition of acid secretion, are benign and appear to be reversible.
Slovenian: Te spremembe so fiziološka posledica izrazito zavrtega izločanja želodčne kisline, so benigne in po vsem sodeč reverzibilne.
English: Concomitant treatment with omeprazole (20 mg daily) and digoxin in healthy subjects increased the bioavailability of digoxin by 10%.
Slovenian: Sočasno zdravljenje z omeprazolom (20 mg na dan) in digoksinom je pri zdravih preiskovancih povečalo biološko uporabnost digoksina za 10 %.
English: No other solvent should be used.
Slovenian: Drugega vehikla se ne sme uporabljati.
English: They could, however, be considered in cases where known hypersensitivity precludes use of any triple combination.
Slovenian: Vendar lahko pridejo v poštev, če zaradi znane preobčutljivosti ni mogoče uporabiti nobene tritirne kombinacije.
English: When doses exceed 60 mg daily, the dose should be divided and given twice daily.
Slovenian: Če odmerki presežejo 60 mg na dan, je treba odmerek razdeliti in ga dati dvakrat na dan.
English: WHAT LOSEC IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO LOSEC IN ZA KAJ GA UPORABLJAMO
English: Concomitant administration of omeprazole with saquinavir/ritonavir resulted in increased plasma levels up to approximately 70% for saquinavir associated with good tolerability in HIV-infected patients.
Slovenian: Uporaba omeprazola hkrati s sakvinavirjem/ritonavirjem je povzročila povečanje koncentracije sakvinavirja v plazmi do približno 70 %, a bolniki, okuženi s HIV, so to dobro prenašali.
English: 280 capsules
Slovenian: 280 kapsul
English: If you forget to take Losec
Slovenian: Če ste pozabili vzeti zdravilo Losec
English: Taste disturbance
Slovenian: motnje okušanja
English: No tachyphylaxis has been observed during treatment with omeprazole.
Slovenian: Med zdravljenjem z omeprazolom niso opazili tahifilaksije.
English: • Severe kidney problems (interstitial nephritis).
Slovenian: • hude težave z ledvicami (intersticijski nefritis)
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je zdravnik povedal, da imate intoleranco za nekatere sladkorje, se z njim posvetujte, preden začnete jemati to zdravilo.
English: Powder and solvent for solution for injection (Powder for injection; and Solvent for injection) pH 8.8 to 9.2
Slovenian: FARMACEVTSKA OBLIKA prašek in vehikel za raztopino za injiciranje (prašek in vehikel za injekcije) pH od 8,8 do 9,2
English: Omeprazole is 97% plasma protein bound.
Slovenian: Omeprazol je 97 % vezan na beljakovine v plazmi.
English: Your doctor will tell you how many capsules to take and how long to take them for.
Slovenian: Zdravnik vam bo povedal, koliko kapsul morate vzeti in koliko časa jih morate jemati.
English: Powder for solution for infusion (Powder for infusion) pH interval in glucose is approximately 8.9-9.5 and in sodium chloride 0.9%, 9.3-10.3
Slovenian: FARMACEVTSKA OBLIKA prašek za raztopino za infundiranje (prašek za infuzijo) Razpon pH v glukozi je približno od 8,9 do 9,5 in v 0,9 % natrijevem kloridu od 9,3 do 10,3.
English: If affected, patients should not drive or operate machinery.
Slovenian: Bolniki, ki se jim to zgodi, ne smejo voziti ali upravljati s stroji.
English: The dispersion should always be stirred just before drinking and rinsed down with half a glass of water.
Slovenian: Disperzijo je treba tik pred pitjem vedno premešati in jo poplakniti s pol kozarca vode.
English: These micro-pellets contain the active substance omeprazole and are enteric coated which protects them from being broken down during passage through the stomach.
Slovenian: Te mikrokroglice vsebujejo zdravilno učinkovino omeprazol in so gastrorezistentne, tako da so zaščitene pred razgradnjo med prehodom skozi želodec.
English: However, due to low affinity to CYP3A4, omeprazole has no potential to inhibit the metabolism of other CYP3A4 substrates.
Slovenian: Toda zaradi majhne afinitete za CYP3A4, omeprazol nima potenciala za zavrtje presnove drugih substratov CYP3A4.
English: • Liver problems, including jaundice which can cause yellow skin, dark urine, and tiredness.
Slovenian: • težave z jetri, vključno z zlatenico, ki lahko povzroči porumenelost kože, temen urin in utrujenost
English: Agitation, confusion, depression
Slovenian: agitiranost, zmedenost, depresija
English: There are limited long term safety data from 46 children who received maintenance therapy of omeprazole during a clinical study for severe erosive esophagitis for up to 749 days.
Slovenian: Na voljo so nezadostni podatki o dolgoročni varnosti, zbrani pri 46 otrocih, ki so v klinični študiji zaradi hudega erozivnega ezofagitisa dobivali vzdrževalno zdravljenje z omeprazolom do 749 dni.
English: Therapeutic drug monitoring of digoxin should be then be reinforced.
Slovenian: V takšnih okoliščinah je treba intenzivneje terapevtsko kontrolirati digoksin.
English: Add approximately 5 ml of the solvent to the vial with freeze-dried omeprazole.
Slovenian: Dodajte približno 5 ml vehikla v vialo z liofiliziranim omeprazolom.
English: H. pylori is a major factor in the development of gastritis.
Slovenian: H. pylori je eden glavnih dejavnikov za nastanek gastritisa.
English: Arthralgia, myalgia
Slovenian: artralgija, mialgija
English: • You are aged over 55 years with new or recently changed symptoms.
Slovenian: • Če ste starejši od 55 let in se vam pojavijo novi simptomi ali se vam simptomi spremenijo.
English: - To make sure that you have drunk all of the medicine, rinse the glass very well with half a glass of water and drink it.
Slovenian: - Da boste popili zares vse zdravilo, kozarec nato zelo dobro splaknite s pol kozarca vode in to vodo popijte.
English: • Yellow skin, dark urine and tiredness which can be symptoms of liver problems.
Slovenian: • Porumenelost kože, temen urin in utrujenost; to so lahko simptomi težav z jetri.
English: Hypersensitivity to omeprazole, substituted benzimidazoles or to any of the excipients.
Slovenian: Preobčutljivost za omeprazol, substituirane benzimidazole ali katerokoli pomožno snov.
English: PHARMACEUTICAL FORM AND CONTENTS 1x40 mg
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 1 x 40 mg
English: HDPE bottle: with a tight fitting polypropylene screw-cap equipped with a desiccant capsule.
Slovenian: Plastenka iz HDPE: z natančno prilegajočo se polipropilensko navojno zaporko, opremljena s kapsulo s sušilom.
English: Bioequivalence between Losec capsules and Losec gastro-resistant tablets, based on both area under the omeprazole plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) of omeprazole, has been demonstrated for all doses, 10 mg, 20 mg and 40 mg.
Slovenian: Bioekvivalentnost kapsul Losec in gastrorezistentnih tablet Losec je bila na podlagi površine pod krivuljo koncentracije omeprazola v plazmi po času (AUC) in največje koncentracije omeprazola v plazmi (Cmax) dokazana za vse odmerke: 10 mg, 20 mg in 40 mg.
English: If the combination of atazanavir with a proton pump inhibitor is judged unavoidable, close clinical monitoring (e.g virus load) is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir; omeprazole 20 mg should not be exceeded.
Slovenian: Če se sočasni uporabi atazanavirja in zaviralca protonske črpalke ni mogoče izogniti, sta priporočljiva natančen klinični nadzor (npr. virusnega bremena) ter povečanje odmerka atazanavirja na 400 mg s 100 mg ritonavirja; odmerek omeprazola ne sme preseči 20 mg.
English: It is recommended to take Losec capsules in the morning, preferably without food, swallowed whole with half a glass of water.
Slovenian: Kapsule Losec je priporočljivo vzeti zjutraj, po možnosti na prazen želodec (brez hrane), in jih zaužiti cele s pol kozarca vode.
English: Losec solution for injection must be given only as an intravenous injection and it must not be added to infusion solutions.
Slovenian: Raztopino za injiciranje Losec se sme uporabiti le v intravenski injekciji in se je ne sme dodajati raztopinam za infundiranje.
English: What to do if you have trouble swallowing the tablets
Slovenian: Kaj storiti, če težko zaužijete tablete
English: If you are not sure, talk to your doctor, nurse or pharmacist before you are given this medicine.
Slovenian: Če ste negotovi, se posvetujte z zdravnikom, medicinsko sestro ali farmacevtom, preden dobite to zdravilo.
English: This increase is dose-dependent and results in a non-linear dose-AUC relationship after repeated administration.
Slovenian: Povečanje je odvisno od odmerka in povzroči nelinearno povezanost med odmerkom in AUC po večkratni uporabi.
English: INFORMATION IN BRAILLE Hospital pack: Justification for not including Braille accepted
Slovenian: PODATKI V BRAILLOVI PISAVI Bolnišnično pakiranje: Sprejeta je utemeljitev, zakaj niso vključeni podatki v Braillovi pisavi.
English: Rotate and shake the vial to ensure all the freeze-dried omeprazole has dissolved.
Slovenian: Vrtite in pretresajte vialo, da boste zagotovili raztopitev liofiliziranega omeprazola.
English: These findings have no implications for the posology of omeprazole.
Slovenian: Ti izsledki ne vplivajo na odmerjanje omeprazola.
English: However, you still need to take Losec carefully to get the best results from it.
Slovenian: Kljub temu ga morate zdravilo Losec jemati pazljivo in skrbno, da vam bo kar najbolje koristilo.
English: • Changes in blood count including agranulocytosis (lack of white blood cells)
Slovenian: • spremembe števila krvnih celic, vključno z agranulocitozo (pomanjkanjem belih krvnih celic)
English: • Allergic reactions, sometimes very severe, including swelling of the lips, tongue and throat, fever,
Slovenian: • alergijske reakcije, ki so včasih zelo hude, vključno z otekanjem ustnic, jezika in žrela, zvišana telesna temperatura, piskajoče dihanje
English: Paediatric patients There is limited experience with Losec for intravenous use in children.
Slovenian: Pediatrični bolniki Z intravensko uporabo zdravila Losec je pri otrocih malo izkušenj.
English: Impaired hepatic function In patients with impaired hepatic function a daily dose of 10-20 mg may be sufficient (see section 5.2).
Slovenian: Bolnikom z okvarjenim delovanjem jeter lahko zadošča dnevni odmerek od 10 do 20 mg (glejte poglavje 5.2).
English: • Severe liver problems leading to liver failure and inflammation of the brain.
Slovenian: • hude težave z jetri, ki povzročijo odpoved jeter in vnetje možganov
English: Malaise, peripheral oedema
Slovenian: splošno slabo počutje, periferni edemi