FrancophonIA/ELRC3.0 huggingface dataset:
English: This study looked at how long the babies survived and whether or not they had neurological disabilities after 18 months.
Slovenian: V tej študiji so proučevali, kako dolgo so novorojenčki preživeli in ali so po 18 mesecih imeli nevrološke okvare.
English: Primary means that the apnoea has no obvious cause.
Slovenian: Izraz „primarna“ pa pomeni, da za apnejo ni očitnega vzroka.
English: This reduces the effect of adenosine, stimulating the brain to resume breathing.
Slovenian: To zmanjša učinek adenozina in stimulira možgane, da se dihanje ponovno začne.
English: Other information about Peyona
Slovenian: Druge informacije o zdravilu Peyona
English: This is a summary of the European public assessment report (EPAR) for Peyona.
Slovenian: To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Peyona.
English: The doctor will stop treatment with Peyona when the baby has five to seven consecutive days without apnoea attacks.
Slovenian: Zdravnik bo zdravljenje z zdravilom Peyona prekinil, ko bo novorojenček pet do sedem zaporednih dni brez napadov apneje.
English: For more information about treatment with Peyona, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Peyona preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: What benefit has Peyona shown during the studies?
Slovenian: Kakšne koristi je zdravilo Peyona izkazalo med študijami?
English: A baby was considered to be in treatment failure if there was no halving of the number of apnoea episodes, if the baby required a machine to assist in breathing or if the baby did not survive.
Slovenian: Zdravljenje je veljalo za neuspešno, če se pri novorojenčku število epizod apneje ni prepolovilo, če je ta potreboval aparat za pomoč pri dihanju ali če ni preživel.
English: Because caffeine citrate has been used in premature babies for a long time, the company presented information from the scientific literature.
Slovenian: Ker se kofein citrat že dolgo uporablja pri nedonošenčkih, je družba predstavila podatke iz strokovne literature.
English: Caffeine citrate is an ‘antagonist' of adenosine, a substance that blocks the activity of some parts of the brain, including the part responsible for controlling breathing.
Slovenian: Kofein citrat je „antagonist“ adenozina, snovi, ki zavira dejavnost določenih delov možganov, vključno z delom, ki je odgovoren za nadzor dihanja.
English: In the large published study, 46% of babies given placebo (431 out of 932) died or had neurological disabilities compared with 40% of babies given caffeine citrate (377 out of 937).
Slovenian: V večji objavljeni študiji je 46 % novorojenčkov, ki so prejeli placebo (431 otrok od 932), umrlo ali imelo nevrološke posledice, med novorojenčki, ki so prejeli kofein citrat, pa je bilo takih 40 % (377 otrok od 937).
English: When judged necessary, the doctor may monitor the level of caffeine in the baby's blood and adjust the dose accordingly.
Slovenian: Zdravnik se lahko po potrebi odloči nadzirati ravni kofeina v krvi novorojenčka in skladno z njimi prilagajati odmerke.
English: The summary of opinion of the Committee for Orphan Medicinal Products for Peyona can be found on the Agency's website ema.europa.eu/Find medicine/Human medicines/Rare disease designation.
Slovenian: Povzetek mnenja Odbora za zdravila sirote o zdravilu Peyona je na voljo na spletni strani agencije na naslovu ema.europa.eu/Find medicine/Human medicines/Rare disease designation.
English: A risk management plan has been developed to ensure that Peyona is used as safely as possible.
Slovenian: Za zagotovitev čim varnejše uporabe zdravila Peyona je bil pripravljen načrt obvladovanja tveganj.
English: Apnoea in newborns is the cessation of breathing for more than 20 seconds.
Slovenian: Apneja pri nedonošenčkih je prekinitev v dihanju za dlje kot 20 sekund.
English: For the full list of all side effects and restrictions with caffeine citrate, see the package leaflet.
Slovenian: Za celoten seznam vseh neželenih učinkov in omejitev pri uporabi kofein citrata glejte navodilo za uporabo.
English: The active substance in Peyona, caffeine citrate, is a stimulant of the nervous system.
Slovenian: Zdravilna učinkovina v zdravilu Peyona, kofein citrat, je spodbujevalec živčnega sistema.
English: Because the number of patients with primary apnoea of premature newborns is low, the disease is considered ‘rare', and Peyona was designated an ‘orphan medicine' (a medicine used in rare diseases) on 17 February 2003.
Slovenian: Ker je nedonošenčkov s primarno apnejo malo, velja ta bolezen za redko, zato je bilo zdravilo Peyona 17. februarja 2003 določeno kot „zdravilo sirota“ (zdravilo, ki se uporablja za zdravljenje redkih bolezni).
English: The most common side effects with caffeine citrate (seen in between 1 and 10 patients in 100) are hyperglycaemia (high blood glucose levels), tachycardia (rapid heartbeat) and phlebitis (inflammation of a vein) and inflammation at the site of infusion.
Slovenian: Najpogostejši neželeni učinki kofein citrata (opaženi pri 1 do 10 bolnikih od 100) so hiperglikemija (visoke koncentracije glukoze v krvi), tahikardija (pospešen srčni utrip) in flebitis (vnetje vene) ter vnetje na mestu infundiranja.
English: Apnoea in premature babies is due to the baby's breathing centres in the brain not being fully developed.
Slovenian: Do apneje pri nedonošenčkih pride zato, ker dihalni centri v njihovih možganih še niso povsem razviti.
English: The full EPAR for Peyona can be found on the Agency's website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila Peyona je na voljo na spletni strani agencije ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: The main measure of effectiveness was based on the reduction by at least a half in the daily number of apnoea episodes over ten days.
Slovenian: Glavno merilo učinkovitosti je bilo zmanjšanje števila dnevnih epizod apneje v desetih dneh za vsaj polovico.
English: Treatment is started with a dose of 20 mg per kilogram bodyweight given once by slow infusion over 30 minutes.
Slovenian: Začetni odmerek znaša 20 mg na kg telesne mase, odmerjen s počasno 30-minutno infuzijo.
English: What is the risk associated with Peyona?
Slovenian: Kakšna tveganja so povezana z zdravilom Peyona?
English: In addition, more babies who were given caffeine citrate had at least eight days with no apnoea: 22% of babies given caffeine citrate compared with none of babies who were given placebo.
Slovenian: Poleg tega je bilo več novorojenčkov, ki so prejeli kofein citrat, vsaj osem dni brez apneje: 22 % novorojenčkov, ki so prejeli kofein citrat, v primerjavi z nobenim novorojenčkom, ki je prejel placebo.
English: The CHMP decided that Peyona's benefits are greater than its risks and recommended that it be given marketing authorisation.
Slovenian: Odbor za zdravila za uporabo v humani medicini (CHMP) je zaključil, da so koristi zdravila Peyona večje od z njim povezanih tveganj, in priporočil, da se zanj izda dovoljenje za promet.
English: Peyona is a solution for infusion (drip) into a vein that contains the active substance caffeine citrate (20 mg/ml).
Slovenian: Zdravilo Peyona je raztopina za infundiranje (kapalno infuzijo v veno), ki vsebuje zdravilno učinkovino kofein citrat (20 mg/ml).
English: Caffeine citrate works in apnoea by blocking the receptors that adenosine normally attaches to.
Slovenian: Kofein citrat pri apneji deluje tako, da zavira receptorje, na katere se adenozin običajno veže.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Peyona.
Slovenian: Pojasnjuje, kako je Odbor za zdravila za uporabo v humani medicini (CHMP) ocenil to zdravilo, na podlagi česar je oblikoval mnenje za izdajo dovoljenja za promet z njim in priporočila glede pogojev njegove uporabe.
English: In six out of ten days caffeine citrate was more effective than placebo in reducing the number of apnoea episodes by at least a half.
Slovenian: V šestih dneh od desetih je bil kofein citrat učinkovitejši od placeba pri zmanjševanju števila epizod apneje za vsaj polovico.
English: Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Peyona, including the appropriate precautions to be followed by healthcare professionals and patients.
Slovenian: V skladu s tem načrtom so bile v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo vključene informacije o varnosti, vključno s previdnostnimi ukrepi, ki jih morajo upoštevati zdravstveni delavci in bolniki.
English: Treatment with the medicine should only take place in an intensive care unit for newborns that is well equipped for monitoring the baby.
Slovenian: Zdravljenje z zdravilom mora potekati izključno na oddelku intenzivne nege za novorojenčke, na katerem so na voljo ustrezni pripomočki za spremljanje novorojenčka.
English: Why has Peyona been approved?
Slovenian: Zakaj je bilo zdravilo Peyona odobreno?
English: Treatment with Peyona should only be started under the supervision of a doctor experienced in treating newborn babies requiring intensive care.
Slovenian: Zdravljenje z zdravilom Peyona je treba začeti pod nadzorom zdravnika z izkušnjami v intenzivni negi novorojenčkov.
English: In a published review of five studies, caffeine and theophylline (another stimulant) were compared with placebo in 192 premature babies with apnoea.
Slovenian: V objavljeni recenziji petih študij so kofein in teofilin (drug spodbujevalec) primerjali s placebom pri 192 nedonošenčkih z apnejo.
English: A large published study compared caffeine citrate with placebo in treating 2,006 premature babies with apnoea.
Slovenian: V večji objavljeni študiji so kofein citrat primerjali s placebom pri zdravljenju 2 006 nedonošenčkov z apnejo.
English: In a published study involving 85 premature babies who had had several episodes of apnoea, caffeine citrate was compared with placebo (a dummy treatment).
Slovenian: V objavljeni študiji s 85 nedonošenčki, ki so imeli več epizod apneje, so kofein citrat primerjali s placebom (zdravilom brez zdravilne učinkovine).
English: The card will contain information on how Peyona should be administered, including doses, the monitoring of plasma caffeine levels and the side effects that may occur during treatment.
Slovenian: Poleg tega se bo družba, ki izdeluje zdravilo Peyona, z državami članicami dogovorila, da bo v intenzivnih enotah, v katerih se uporablja zdravilo, obešena kartica, na kateri bodo informacije o uporabi zdravila Peyona, vključno z odmerki, spremljanjem ravni kofeina v plazmi ter neželenimi učinki, do katerih lahko pride med zdravljenjem.
English: The solution can also be given by mouth.
Slovenian: Raztopina se lahko zaužije tudi peroralno.
English: In the review of five studies, fewer babies treated with caffeine or theophylline had treatment failure compared with placebo.
Slovenian: V recenziji petih študij je bilo zdravljenje redkeje neuspešno pri novorojenčkih, ki so se zdravili s kofeinom ali teofilinom, kot pri novorojenčkih, ki so prejeli placebo.
English: What is Peyona used for?
Slovenian: Za kaj se zdravilo Peyona uporablja?
English: Caffeine citrate was more effective than placebo at treating apnoea in premature babies.
Slovenian: Kofein citrat je bil za zdravljenje apneje pri nedonošenčkih učinkovitejši od placeba.
English: How has Peyona been studied?
Slovenian: Kako je bilo zdravilo Peyona raziskano?
English: After 24 hours, a ‘maintenance dose' of 5 mg per kg bodyweight may be given everyday
Slovenian: Po 24 urah se lahko vsak dan daje vzdrževalni odmerek v odmerku 5 mg na kg telesne mase s počasno 10-minutno infuzijo ali peroralno skozi nazogastrično cevko (cevko, speljano skozi nos v želodec).
English: How does Peyona work?
Slovenian: Kako zdravilo Peyona deluje?
English: How is Peyona used?
Slovenian: Kako se zdravilo Peyona uporablja?
English: What is Peyona?
Slovenian: Kaj je zdravilo Peyona?
English: Peyona is used to treat primary apnoea in premature newborns.
Slovenian: Zdravilo Peyona se uporablja za zdravljenje primarne apneje pri nedonošenčkih.
English: This advice is applicable to all indications and to all special populations.
Slovenian: Ta nasvet se nanaša na vse indikacije in vse posebne populacije.
English: Interrupt until resolved to grade 0-1
Slovenian: Prekiniti, dokler ne doseže stopnje 0-1
English: • blurred or double vision
Slovenian: • zamegljen ali dvojni vid
English: • specific changes in the electrocardiogram (QT prolongation)
Slovenian: • specifične spremembe v elektrokardiogramu (podaljšanje QT)
English: - It is important that you take all your medicine as prescribed by your doctor.
Slovenian: • Pomembno je, da jemljete vsa zdravila tako, kot vam je predpisal zdravnik.
English: Interferon alpha
Slovenian: Interferon alfa
English: This will help reduce the likelihood that the side effect continues or becomes severe.
Slovenian: To bo pomagalo zmanjšati verjetnost, da bi se neželeni učinki nadaljevali ali postali resni.
English: - Take the tablets morning and evening as prescribed by your doctor.
Slovenian: • Tablete jemljite zjutraj in zvečer, kot vam jih je predpisal zdravnik.
English: Tell your doctor immediately if you experience any of these symptoms.
Slovenian: Takoj obvestite zdravnika, če imate katerega od teh simptomov.
English: • Nausea: if you lose your appetite, and the amount of food you eat each day is much less than usual.
Slovenian: • Slabost: če izgubite tek in če je količina hrane, ki jo zaužijete vsak dan mnogo manjša kot ponavadi.
English: • Fever: if you have a temperature of 38°C or greater.
Slovenian: • Zvišana telesna temperatura: če imate telesno temperaturo 38 °C ali več.
English: • Infection: if you experience signs of infection caused by bacteria or virus, or other organisms.
Slovenian: • Okužba: če imate znake okužbe, ki jo povzroči bakterija ali virus ali drugi organizmi.
English: Once the dose has been reduced, it should not be increased at a later time.
Slovenian: Po znižanju se odmerka kasneje ne sme povečati.
English: Do not give capecitabine to children and adolescents.
Slovenian: Otrokom in mladostnikom ne dajajte kapecitabina.
English: • Vomiting: if you vomit more than once in a 24-hour time period.
Slovenian: • Bruhanje: če bruhate več kot enkrat v 24 urah.
English: Severe and/or Life-threatening (grade 3-4) or considered medically relevant
Slovenian: Resni in/ali življenjsko ogrožujoči (stopnja 3-4) ali medicinsko pomembni
English: • If contraindications exist to any of the medicinal products in the combination regimen, that medicinal product should not be used.
Slovenian: • Če obstajajo kontraindikacije za katero od zdravil, ki se uporablja v kombinaciji, se tega zdravila ne sme uporabljati.
English: Hand and foot skin-reaction can lead to loss of fingerprint, which could impact your identification by fingerprint scan.
Slovenian: Kožna reakcija na rokah in nogah lahko povzroči izgubo prstnih odtisov, kar bi lahko vplivalo na vašo identifikacijo s prstnimi odtisi.
English: • allergy
Slovenian: • alergija
English: DPD deficiency: DPD deficiency is a rare condition present at birth that is not usually associated with health problems unless you receive certain medicines.
Slovenian: Pomanjkanje DPD: Pomanjkanje DPD je redko prirojeno stanje, ki navadno ne povzroča težav z zdravjem, razen če prejmete določena zdravila.
English: - Take the tablets within 30 minutes after the end of a meal (breakfast and dinner) and swallow whole with water.
Slovenian: • Tablete zaužijte v 30 minutah po koncu obroka (zajtrka in večerje); tablete pogoltnite cele z vodo.
English: taste changes
Slovenian: sprememba okusa
English: Merckle GmbH Ludwig Merckle Str. 3 89143 Blaubeuren Germany
Slovenian: Merckle GmbH Ludwig Merckle Str. 3 89143 Blaubeuren Nemčija
English: • difficulty in urination, blood or protein in the urine
Slovenian: • težave pri uriniranju, kri ali beljakovine v urinu
English: • sleeplessness (insomnia), depression
Slovenian: • nespečnost (insomnia), depresija
English: • jaundice (yellowing of skin and eyes)
Slovenian: • zlatenica (porumenevanje kože in oči)
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 or fluorouracil,
Slovenian: • Preobčutljivost na učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1 ali fluorouracil.
English: Dehydration should be prevented or corrected at the onset.
Slovenian: Dehidracijo moramo preprečiti ali popraviti takoj na začetku.
English: Other than warfarin, no formal interaction studies between capecitabine and other CYP2C9 substrates have been conducted.
Slovenian: Razen z varfarinom, formalnih študij medsebojnega delovanja med kapecitabinom in drugimi substrati CYP2C9 niso izvedli.
English: (see section 4.4),
Slovenian: (glejte poglavje 4.4).
English: Date of latest renewal: 09 January 2017
Slovenian: Datum prve odobritve: 20. april 2012 Datum zadnjega podaljšanja: 09. januar 2017
English: Other side effects are:
Slovenian: Ostali neželeni učinki so:
English: Capecitabine Teva tablets are usually taken for 14 days followed by a 7 day rest period (when no tablets are taken).
Slovenian: Tablete zdravila Kapecitabin Teva se običajno jemljejo 14 dni, čemur sledi 7-dnevni premor (ko se tablet ne jemlje).
English: In the event of grade 2-4 acute toxicity, treatment must be discontinued immediately.
Slovenian: V primeru akutnih toksičnosti stopnje 2−4 je treba zdravljenje nemudoma prekiniti.
English: • inflammation of the skin causing red scaly patches due to an immune system illness
Slovenian: • vnetje kože, ki povzroči rdeče srbeče zaplate zaradi bolezni imunskega sistema
English: Film-coated tablet.
Slovenian: filmsko obložena tableta.
English: The AUC of FBAL increased with age (20% increase in age results in a 15% increase in the AUC of FBAL).
Slovenian: AUC za FBAL je z leti naraščala (20 % povečanje v letih daje 15 % povečanje AUC za FBAL).
English: • In patients with known complete absence of dihydropyrimidine dehydrogenase (DPD) activity
Slovenian: • Pri bolnikih z znano popolno odsotnostjo aktivnosti dihidropirimidin dehidrogenaze (DPD)
English: Doses of capecitabine omitted for toxicity are not replaced.
Slovenian: Odmerkov kapecitabina, ki so izpuščeni zaradi toksičnosti, se ne nadomešča.
English: fluoro-ureidopropionic acid (FUPA).
Slovenian: fluoro-ureidopropionska kislina (FUPA).
English: This medicine contains less than 1 mmol sodium (23 mg) per film-coated tablet, that is to say essentially “sodium-free”.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na filmsko obloženo tableto, kar v bistvu pomeni ‘brez natrija'.
English: intravenous bolus injection immediately after leucovorin
Slovenian: intravenska injekcija v bolusu neposredno po levkovorinu
English: • bruising or reaction at the injection site (caused by medicines given by injection at the same time)
Slovenian: • modrice ali reakcije na mestu injiciranja (ki jih povzročijo zdravila, ki so injicirana sočasno)
English: Patients with renal impairment (see section 4.2, 4.4, and 5.2):
Slovenian: Bolniki z ledvično okvaro (glejte poglavja 4.2, 4.4 in 5.2):
English: Do not take Capecitabine Teva - if you are allergic to capecitabine or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Kapecitabin Teva: - če ste alergični na kapecitabin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: For hand-foot syndrome and hyperbilirubinemia, see section 4.4.
Slovenian: Za sindrom roka-noga in hiperbilirubinemijo glejte poglavje 4.4.
English: • ringing or buzzing in the ears (tinnitus), loss of hearing
Slovenian: • zvonjenje in brenčanje v ušesih (tinitus), izguba sluha
English: Dose adjustment for next cycle/dose (% of starting dose)
Slovenian: Prilagoditev odmerka pri naslednjem ciklu/odmerku (% začetnega odmerka)
English: The following are the recommended dose modifications for toxicity:
Slovenian: V nadaljevanju so priporočeni spremenjeni odmerki za toksičnosti.
English: • infections of the lungs or respiratory system (e.g. pneumonia or bronchitis)
Slovenian: • okužbe pljuč ali respiratornega sistema (na primer pljučnica ali bronhitis)
English: If you have taken brivudine you must wait for at least 4 weeks after stoping brivudine before starting to take capecitabine.
Slovenian: Če ste jemali brivudin, morate po končanem jemanju brivudina počakati najmanj 4 tedne, preden začnete jemati kapecitabin.
English: It is not known whether capecitabine is excreted in human breast milk.
Slovenian: Ni znano, ali se kapecitabin izloča v materino mleko.
English: These side effects can become severe; therefore, it is important that you always contact your doctor immediately when you start to experience a side effect.
Slovenian: Ti neželeni učinki lahko postanejo resni, zato je pomembno, da se takoj posvetujete z zdravnikom, če se pojavijo.
English: • eye inflammation causing eye pain and possibly eyesight problems
Slovenian: • vnetje oči, ki povzroči boleče oči in morda težave z vidom
English: Some of these side effects are more common when capecitabine is used with other medicines for the treatment of cancer.
Slovenian: Nekateri od teh neželenih učinkov so bolj pogosti kadar se kapecitabin uporablja z drugimi zdravili za zdravljenje raka.
English: Placebo or Bevacizumab
Slovenian: placebo ali bevacizumab
English: Toxicity due to capecitabine administration may be managed by symptomatic treatment and/or modification of the dose (treatment interruption or dose reduction).
Slovenian: Toksičnost zaradi prejemanja kapecitabina se lahko nadzoruje s simptomatskim zdravljenjem in/ali spreminjanjem odmerka (prekinitev zdravljenja ali zmanjšanje odmerka).
English: Only after being absorbed by the body is it changed into an active anti-cancer medicine (more in tumour tissue than in normal tissue).
Slovenian: Šele po absorpciji v telesu se spremeni v aktivno citostatično učinkovino (bolj v tumorskem tkivu kot v zdravih tkivih).
English: Since metabolism of R-warfarin was not affected, these results indicate that capecitabine down-regulates isozyme 2C9, but has no effect on isozymes 1A2 and 3A4.
Slovenian: Ker na presnovo R-varfarina ni bilo vpliva, ti rezultati nakazujejo, da kapecitabin zavira izoencim 2C9, ne vpliva pa na izoencima 1A2 in 3A4.
English: The following headings are used to rank the ADRs by frequency: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000).
Slovenian: Neželeni učinki so razvrščeni po njihovi pogostnosti: zelo pogosti (≥ 1/10), pogosti (≥ 1/100, < 1/10), občasni (≥ 1/1.000, < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000).
English: • unusual bleeding from the vagina
Slovenian: • neobičajno krvavenje iz nožnice
English: Your doctor may instruct you to decrease the dose and/or temporarily discontinue treatment with Capecitabine Teva.
Slovenian: Zdravnik vam bo morda zmanjšal odmerek in/ali začasno prekinil zdravljenje z zdravilom Kapecitabin Teva.
English: Capecitabine has minor or moderate influence on the ability to drive and use machines.
Slovenian: Kapecitabin ima blag ali zmeren vpliv na sposobnost vožnje in upravljanja strojev.
English: Cytochrome P-450 2C9 substrates
Slovenian: Substrati citokroma P-450 2C9
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, ATC code: L01BC06
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe, antimetaboliti, oznaka ATC: L01BC06.
English: • Chest pain: if you experience pain localised to the centre of the chest, especially if it occurs during exercise.
Slovenian: • Bolečina v prsnem košu: če občutite bolečino, omejeno na sredino prsnega koša, še posebno, če se pojavi med naporom.
English: -2nd appearance
Slovenian: -drugo pojavljanje
English: Discontinue treatment permanently
Slovenian: Trajno prekiniti zdravljenje