FrancophonIA/ELRC3.0 huggingface dataset:
English: Common side effects (may affect up to 1 in 10 people): - Fall in blood pressure - Breathlessness, noisy breathing (a high pitched sound resulting from obstructed air flow in the upper airway) - Rash and inflammation of the lining of the mouth, itching, itching rash, hives - Kidney problems which may be detected primarily by blood tests - Redness of upper body and face, inflammation of a vein Uncommon side effects (may affect up to 1 in 100 people): - Temporary or permanent loss of hearing
Maltese: Effetti sekondarji komuni (dawn jistgħu jaffettwaw sa pesuna waħda minn kull 10) - Waqa' fil-pressjoni tad-demm - Qtugħ ta' nifs, nifs storbjużi (ħoss immejla għolja li tirriżulta minn fluss ta' arja ostakolat fil passaġġ tan-nifs) - Ġeneralizzat u infjammazzjoni ta ' l-inforra tal-ħalq, itching, itching rash, ġarar tan-naħal - Problemi fil-kliewi li jistgħu jiġu skoperti primarjament permezz ta ' testijiet tad-demm - Ħmura tal-ġisem u l-wiċċ, infjammazzjoni ta' vina Effetti sekondarji mhux komuni (dawn jistgħu jaffettwaw sa pesuna waħda minn kull 100)
English: Patients whose fluid intake must be limited can also receive a solution of 500 mg/50 ml or 1000 mg/100 ml, although the risk of infusion-related undesirable effects can be increased with these higher concentrations.
Maltese: Il-pazjenti li t-teħid ta' fluwidu għandu jkun limitat jistgħu wkoll jirċievu soluzzjoni ta' 500 mg/50 ml jew 1000 mg/100 ml, għalkemm ir-riskju ta' effetti mhux mixtieqa relatati mal-infużjoni jistgħu jiżdiedu ma' dawn il-konċentrazzjonijiet ogħla.
English: Pharmacokinetic/ Pharmacodynamic relationship
Maltese: Relazzjoni farmaokinetika/farmakodinamika:
English: Half-life varies between 3.5 and 10 h and is longer than in adults, reflecting the usual lower values for clearance in the neonate.
Maltese: In-nofs-ħajja tvarja bejn 3.5 u 10 s u huwa itwal minn fl-adulti, li jirriflettu l-valuri aktar baxxi tas-soltu għall-clearance fil-neonate.
English: NAME OF THE MEDICINAL PRODUCT [For all vancomycin 125 mg capsule] <{(Invented) vancomycin 125mg capsule}> [For all vancomycin 250 mg capsule] <{(Invented) vancomycin 250mg capsule}>
Maltese: [Għal vancomycin 125 mg kapsula kollha] <{(Ivvintat) vancomycin kapsula 125mg}> [Għal vancomycin 250 mg kapsuli kollha] <{(Ivvintat) vancomycin kapsula 250mg}>
English: [For parenteral formulations authorised for intraperitoneal use:] - In patients receiving peritoneal dialysis, vancomycin is used in adults and children for the treatment of infections related to peritoneal dialysis.
Maltese: [Għal formulazzjonijiet parenterali awtorizzati għall-użu intraperitonali:] - F'pazjenti li qed jirċievu dijaliżi peritoneali, il-vancomycin jintuża fl-adulti u fit-tfal għattrattament ta' infezzjonijiet relatati mal-dijalisi peritoneali.
English: [For all vancomycin 1000 mg powder for concentrate for solution for infusion] <{(Invented) vancomycin 1000mg powder for concentrate for solution for infusion}>
Maltese: [Għall-vankomiċin kollha 1000 mg trab għal konċentrat għal soluzzjoni għall-infużjoni] < {(Invented) vankomiċin 1000mg trab għal konċentrat għal soluzzjoni għall-infużjoni} >
English: The recommended vancomycin dose is 125 mg every 6 hours for 10 days for the first episode of nonsevere CDI.
Maltese: Id-doża rrakkomandata ta' vancomycin hija ta' 125 mg kull 6 sigħat għal 10 ijiem għall-ewwel episodju ta' CDI mhux severa.
English: Development of Drug-Resistant Bacteria
Maltese: Żvilupp ta' batterji reżistenti tad-droga
English: Anti-diarrhoeic medicinal products must not be given.
Maltese: Prodotti mediċinali kontra ddiarrhoeam'għandhomx jingħataw.
English: Hypersensitivity reactions, anaphylactic reactions Ear and labyrinth disorders:
Maltese: Reazzjonijiet iposensitivi, reazzjonijiet anafilattiċi Disturbi fil- widnejn u sistema labrintika:
English: In anephric patients, the mean half-life is 7.5 days.
Maltese: F'pazjenti anefrika, in-nofs-ħajja medja hija ta' 7.5 ġranet.
English: The recommended vancomycin dose is 10 mg/kg orally every 6 hours for 10 days.
Maltese: Id-doża rrakkomandata ta' vankomiċin huwa 10 mg/kg oralment kull 6 sigħat għal għaxart ijiem.
English: Vancomycin PK has shown wide inter-individual variability in preterm and term neonates.
Maltese: Il-vancomycin PK wriet varjabilità wiesgħa bejn l-individwi fil-prematuri u tul trabi tat-twelid.
English: The usual infusion dose is 10 to 15 mg for each kg of body weight.
Maltese: Id-dosaġġ normali ta' infużjoni huwa ta' 10 to 15 mg għal kull piż tal-ġisem.
English: except Clostridium innocuum
Maltese: Clostridium spp. except Clostridium innocuum Eubacterium spp.
English: Nephrotoxicity has been described in children, usually in association with other nephrotoxic agents such as aminoglycosides.
Maltese: In-Nefrotossiċità ġiet deskritta fit-tfal, ġeneralment assoċċjata m' aġenti nefrotossiċi oħra bħal aminoglycosides.
English: Contents of the pack and other information Other sources of information
Maltese: Kontenut tal-pakkett u informazzjoni oħra Sorsi oħra ta' informazzjoni Tagħrif/edukazzjoni medika
English: The maximum daily dose should not exceed 2 g.
Maltese: Id-doża massima ta' kuljum ma għandhiex taqbeż 2 g.
English: Continuous infusion: loading dose of 1000 mg/L per litter of dialysate followed by 25 mg/L (after 3-6 h of loading dose) in all exchanges.
Maltese: Infużjoni kontinwu: it-tagħbija ta' doża ta' 1000 mg/L għal kull litter tad-dialysate segwit minn 25 mg/L (wara 3-6 h tad-doża tat-tagħbija) fl-iskambji kollha.
English: Uptake of vancomycin from the gastrointestinal tract is negligible.
Maltese: L-assorbiment ta' vancomycin mill-passaġġ gastrointestinali huwa negliġibbli.
English: Intravenous administration of vancomycin is not effective for the treatment of Clostridium difficile infection.
Maltese: L-amministrazzjoni intravinuża ta' vankomiċin ma jkunx effettiv għat-trattament ta' l-infezzjoni Clostridium difficile.
English: *Continue until further debridement is not necessary, patient has clinically improved, and patient is afebrile for 48 to 72 hours **Longer courses of oral suppression treatment with suitable antibiotics should be considered for prosthetic joint infections ***Duration and need for combination therapy is based on valve-type and organism
Maltese: * Tkompli sakemm ma jkunx meħtieġ aktar tneħħija ta'ċelloli nekrotizzati jew materja oħra, il-pazjent ikun tjieb klinikament, u l-pazjent ikun ilu mingħajr deni għal 48 sa 72 siegħa ** Korsijiet itwal ta' kura ta' soppressjoni orali ma' antibijotiċi xierqa għandhom jiġu meqjusa għal infezzjonijiet ta' ġogi prostetiċi. *** It-tul u l-ħtieġa għat-terapija tal-kombinazzjoni hija bbażata fuq it-tip ta' valv u organiżmu Popolazzjonijiet speċjali
English: Adults and adolescents (from 12 years and older) The dosage will be calculated according to your body weight.
Maltese: Adulti u adolexxenti (minn 12-il sena u anzjani) Id-dożaġġ ser tkun maħduma skont il-piż ta' ġismek.
English: The drug is bactericidal for dividing microorganisms.
Maltese: Il-mediċina hija batteriċida għall- mikro-organiżmi waqt id-diviżjoni.
English: When vancomycin is administered parenterally, the most common adverse reactions are phlebitis, pseudo-allergic reactions and flushing of the upper body (“red-neck syndrome”) in connection with too rapid intravenous infusion of vancomycin.
Maltese: Meta vancomycin jingħata parenteralment, ir-reazzjonijiet avversi l-aktar komuni huma flebite, reazzjonijiet psewdo allerġiċi u fwawar tal-ġisem ("sindromu għonq-aħmar") b'rabta mal-infużjoni mgħaġġel wisq fil-vini ta' vancomycin.
English: [For parenteral formulations authorised for oral use:] If given for treatment of gastric disorders (so called Pseudomembranous colitis), the medicinal product must be administrated as a solution for oral use (you will take the medicine by mouth).
Maltese: [Għal formulazzjonijiet parenterali awtorizzati għall-użu orali:] Jekk jingħata trattament ta 'disturbi gastriċi (hekk imsejħa kolite psewdomembranuża), il-prodott mediċinali jistgħu jiġu amministrati bħala soluzzjoni għall-użu orali (inti se tieħu l-mediċina mill-ħalq).
English: Nephrotoxicity
Maltese: Reazzjoni avversa
English: The efficacy and safety of vancomycin has not been established for the intrathecal, intralumbar and intraventricular routes of administration.
Maltese: L-effikaċja u sigurtà tal-vankomiċin ma ġiex stabbilit għar-rotot ta' amministrazzjoni.-intrathecal, intralumbar u intraventricular.
English: Ototoxicity, which may be transitory or permanent (see section 4.8) has been reported in patients with prior deafness, who have received excessive intravenous doses, or who receive concomitant treatment with another ototoxic active substance such as an aminoglycoside.
Maltese: L-ototossiċità, li tista' tkun tranżitorja jew permanenti (ara sezzjoni 4.8) ġiet rrappurtata fil-pazjenti b'telf ta' smigħ minn qabel, li jkunu rċevew dożi intravinuża eċċessiv, jew li jirċievu trattament konkomittenti tas-sustanza attiva ototossiċi ieħor bħal xi aminoglycoside.
English: However, absorption may be enhanced in patients with inflammatory disorders of the intestinal mucosa or with Clostridium difficile-induced pseudomembranous colitis.
Maltese: Però, l-assorbiment jista' jiżdied f'pazjenti b'diżordni inflamatorji tal-mukoża intestinali jew bil- pseudomembranous colitis li huwa Clostridium difficile-induced.
English: Ototoxicity
Maltese: Ototossiċità
English: Whenever possible the antibacterial suspected to have caused CDI should be discontinued.
Maltese: Kull meta jkun possibbli, l-antibatteriċi suspettat li kkawżaw CDI għandu jitwaqqaf.
English: 24 hourly
Maltese: Kull 24 siegħa
English: PMA: post-menstrual age [(time elapsed between the first day of the last menstrual period and birth (gestational age) plus the time elapsed after birth (post-natal age)].
Maltese: PMA: età wara l-età menstruali [(żmien li għadda bejn l-ewwel jum ta' l-aħħar perjodu menstruwali u tat-twelid (età gestazzjonali) flimkien maż-żmien li għadda wara t-twelid (età wara t-twelid)].
English: Similarly, concomitant use with other medicines such as aminoglycoside antibiotics, nonsteroidal anti-inflammatory agents (NSAIDs, e.g., ibuprofen) or amphotericin B (medicine for fungal infection) can increase the risk of kidney damage and therefore more frequent blood and renal test may be necessary.
Maltese: Bl-istess mod, użu konkomittenti b'mediċini oħra bħal ma huma antibijotiċi aminoglycoside, aġenti anti-infjammatorji mhux sterojdi (NSAID, eż., ibuprofen) jew amphotericin B (mediċina għall-infezzjoni fungali) jistgħu jżidu r-riskju ta' ħsara tal-kliewi u għalhekk aktar frekwenti tad-demm u renali tat-test jistgħu ikunu meħtieġa.
English: In some countries, increasing cases of resistance are observed particularly in enterococci; multi-resistant strains of Enterococcus faecium are especially alarming.
Maltese: F'xi pajjiżi, il-każijiet ta' reżistenza li dejjem jiżdiedu huma osservati b'mod partikolari fl enterococci; razez multi-reżistenti ta' Enterococcus faecium huma partikolarment allarmanti.
English: In addition, appropriate information should be given under Method of administration and in section 6.6.]
Maltese: Barra minn hekk, informazzjoni xierqa għandha tingħata skond il-metodu ta' amministrazzjoni u fis-Sezzjoni 6.6.]
English: Patients aged 12 years and older
Maltese: Tfal b'età minn xahar sa inqas minn 12-il sena
English: Common side effects (may affect up to 1 in 10 people): - Fall in blood pressure - Breathlessness, noisy breathing (a high pitched sound resulting from obstructed air flow in the upper airway) - Rash and inflammation of the lining of the mouth, itching, itching rash, hives
Maltese: Effetti sekondarji komuni (dawn jistgħu jaffettwaw sa pesuna waħda minn kull 10) - Taqa' il-pressjoni tad-demm - Qtugħ ta' nifs, nifs storbjużi (ħoss immejla għolja li tirriżulta minn fluss ta' arja ostakolat fil passaġġ tan-nifs) - Ġeneralizzat u infjammazzjoni ta' l-inforra tal-ħalq, itching, itching rash, ġarar tan-naħal
English: In contrast, high concentrations of vancomycin are found in the faeces (>3100 mg/kg with doses of 2 g/day).
Maltese: B'kuntrast, konċentrazzjonijiet għoljin tal-vankomiċin huma misjuba fil-ħmieġ (> 3100 mg/kg b'dożi ta' 2 g/jum).
English: In the first 24 hours, approximately 80 % of an administered dose of vancomycin is excreted in the urine through glomerular filtration.
Maltese: Fl-ewwel 24 siegħa, madwar 80% tad-doża mogħtija ta' vankomiċin jitneħħa flawrina permezz ta' filtrazzjoni glomerulari.
English: In case of severe persistent diarrhoea the possibility of pseudomembranous enterocolitis that might be life-threatening has to be taken into account (see section 4.8).
Maltese: Fil-każ ta' dijarea severa persistenti l-possibilità ta' enterocolitis pseudomembranous li jista' jkun li thedded il-ħajja trid tittieħed in konsiderazzjoni (ara sezzjoni 4.8).
English: Vancomycin should be infused slowly (see sections 4.2 and 4.4).
Maltese: Vankomiċin għandu jkun infuż bil-mod (ara sezzjonijiet 4.2 u 4.4).
English: However, use of high-flux membranes and continuous renal replacement therapy (CRRT) increases vancomycin clearance and generally requires replacement dosing (usually after the haemodialysis session in case of intermittent haemodialysis).
Maltese: Madankollu, l-użu ta' membrani highflux u terapija ta'sostituzzjoni renali kontinwu (CRRT) iżid it-tneħħija ta'vankomiċin u ġeneralment jeħtieġ tibdil tad-doża (is-soltu wara s-sessjoni ta' haemodialysis fil-każ ta' l-haemodialysis intermittenti).
English: Vancomycin is also indicated in all age groups for the perioperative antibacterial prophylaxis in patients that are at high risk of developing bacterial endocarditis when undergoing major surgical procedures.
Maltese: Vankomiċin huwa indikat ukoll fil-gruppi kollha ta' età għall-profilassi kontra l-batterja perioperative filpazjenti li huma f'riskju għoli li jiżviluppaw endocarditis batterjali waqt li jkunu għaddejjin minn proċeduri kirurġiċi maġġuri.
English: Hypersensitivity reactions
Maltese: Reazzjonijiet ta' ipersensittività
English: This may be associated with a high fever and joint pains - Cardiac arrest - Inflammation of the bowel which causes abdominal pain and diarrhea, which may contain blood Not known (frequency cannot be estimated from the available data): - Being sick (throwing up), diarrhoea - Confusion, drowsiness, lack of energy, swelling, fluid retention, decreased urine - Rash with swelling or pain behind the ears, in the neck, groin, under the chin and armpits (swollen lymph nodes), abnormal blood and liver function tests - Rash with blisters and fever.
Maltese: - Li jkunu morda (apparati), diarrea - Konfużjoni, sturdament, nuqqas ta ' l-enerġija, li jintefaħ, żamma ta ' fluwidu, urina mnaqqsa - Rash bl-infiħ jew uġigħ wara l-widnejn, fil-għonq, aġġjaċenti, taħt il-geddum u armpits
English: [This section should read as follows:]
Maltese: [Din is-sezzjoni għandha tinqara kif ġej:]
English: Monitoring of vancomycin serum concentrations
Maltese: Monitoraġġ tal-konċentrazzjonijiet tal-vankomiċin fis-serum
English: Pregnancy
Maltese: Disestesija
English: Testing for Clostridium difficile colonization or toxin is not recommended in children younger than 1 year due to high rate of asymptomatic colonisation unless severe diarrhoea is present in infants with risk factors for stasis such as Hirschsprung disease, operated anal atresia or other severe motility disorders.
Maltese: Ittestjar ta' kolonizzazzjoni jew it-tossin għal Clostridium difficile mhux rrakkomandat fit-tfal iżgħar minn sena minħabba r-rata għolja ta' kolonizzazzjoni asimptomatiċi sakemm dijarea severa hija preżenti fit-trabi bil-fatturi ta' riskju għal stasis bħal marda Hirschsprung, anal atresia operati jew diżordnijiet oħra severi li jaffettwaw il-motilità.
English: [For all vancomycin 500 mg powder for concentrate for solution for infusion] <{(Invented) vancomycin 500mg powder for concentrate for solution for infusion}>
Maltese: [Għat-trab tal-Vancomycin 500 mg kollu għal konċentrat għal soluzzjoni għal infużjoni] < {(Ivvintat) trab tal-Vancomycin 500 mg kollu għal konċentrat għal soluzzjoni għal infużjoni} >
English: Monitoring vancomycin serum concentrations after oral administration in patients with inflammatory intestinal disorders should be performed (see section 4.4).
Maltese: Għandu jsir monitoraġġ ta' konċentrazzjonijiet fis-serum ta' vancomycin wara amministrazzjoni orali f'pazjenti b'disturbi intestinali infjammatorji (ara sezzjoni 4.4).
English: Acquired resistance to glycopeptides is most common in enterococci and is based on acquisition of various van gene complexes which modifies the D-alanyl-D-alanine target to D-alanyl-D-lactate or Dalanyl-D-serine which bind vancomycin poorly.
Maltese: Reżistenza miksuba għall-glikopeptidi huwa l-aktar komuni f'enterococci u hija bbażata fuq l-akkwist ta' diversi kumplessi ġeni van li jimmodifika l-D-Alanyl--D aminotransferase mira sa D-Alanyl-D-lattat jew D-Alanyl-D-serine li jorbtu ħażin ma' vancomycin.
English: In these subpopulations vancomycin serum concentration were found higher than expected in male healthy adults (see section 4.2).
Maltese: F'dawn issubpopolazzjonijiet il-konċentrazzjoni li serum vankomiċin nstabu ogħla milli mistenni fl-adulti rġiel b'saħħithom (ara sezzjoni 4.2).
English: Also, methicillinresistant staphylococcus strains (MRSA) with reduced susceptibility for vancomycin were reported.
Maltese: Ukoll, ir-razez staphylococcus reżistenti għall- methicillin (MRSA) b'suxxettibilità mnaqqsa għall-vankomiċin kienu rrappurtati.
English: Dose adjustments in adult patients could be based on glomerular filtration rate estimated (eGFR) by the following formula:
Maltese: Aġġustamenti fid-doża fil-pazjenti adulti jistgħu jiġu bbażati fuq rata ta' filtrazzjoni glomerular (eGFR) ikkalkulata mill-formula li ġejja:
English: Regular monitoring of the blood levels of vancomycin is indicated in high dose therapy and longer-term use, particularly in patients with renal dysfunction or impaired faculty of hearing as well as in concurrent administration of nephrotoxic or ototoxic substances, respectively (see section 4.2).
Maltese: Monitoraġġ regolari tal-livelli tal-vankomiċin fid-demm huwa indikat f'-terapija ta' doża għolja u l-użu fuq perijodu itwal, b'mod partikolari fil-pazjenti b'funzjoni renali mnaqqsa jew imfixkla jew fi -smigħ imnaqqas kif ukoll fl-amministrazzjoni konkorrenti ta ' sustanzi nephrotossici jew sustanzi ototossiċi, rispettivament (ara sezzjoni 4.2).
English: Biotransformation
Maltese: KWALITATTIVI
English: Vancomycin is not usually absorbed into the blood after oral administration.
Maltese: Vancomycin mhuwiex normalment assorbit fid-demm wara l-għoti orali.
English: In the critically ill patient with renal insufficiency, the initial loading dose (25 to 30 mg/kg) should not be reduced.
Maltese: Fil-pazjenti kritikament morda bl-insuffiċjenza renali, ma għandhiex titnaqqas id-doża inizjali tattagħbija (25 sa 30 mg/kg).
English: All patients receiving vancomycin should have periodic haematologic studies, urine analysis, liver and renal function tests.
Maltese: Il-pazjenti kollha li jirċievu vankomiċin għandhom jkollhom studji haematoloġiċi, analiżi tal-urina, fwied u testijiet tal-funzjoni renali perjodikalment,
English: NAME OF THE MEDICINAL PRODUCT [For all vancomycin 500 mg powder for concentrate for solution for infusion] <{(Invented) vancomycin 500mg powder for concentrate for solution for infusion}>
Maltese: U KWANTITATTIVI [Għall-vankomiċin kollu 500 mg trab għal konċentrat għal soluzzjoni għall-infużjoni, il-kliem li ġejjin biex tkun riflessa f'din it-Taqsima]
English: Oral administration [This section must include instructions for preparation and administration of the oral solution.
Maltese: [Din is-sezzjoni għandha tinkludi istruzzjonijiet għall-preparazzjoni u l-amministrazzjoni tas-soluzzjoni orali.
English: Serial monitoring of renal function should be performed when treating patients with underlying renal dysfunction or patients receiving concomitant therapy with an aminoglycoside or other nephrotoxic drugs.
Maltese: Il-monitoraġġ tas-serje tal-funzjoni renali għandha tkun imwettqa meta jittrattaw pazjenti b'kundizzjonijiet renali sottostanti jew pazjenti li jirċievu terapija konkomitanti ma' xi aminoglycoside jew oħra drogi nephrotoxic.
English: There is no cross-resistance between vancomycin and other classes of antibiotics.
Maltese: M'hemm l-ebda reżistenza inkroċjata bejn vancomycin u klassijiet oħrajn ta' antibijotiċi.
English: Spectrum of antibacterial activity
Maltese: Firxa ta' attività antibatterika:
English: Anaesthetic induced myocardial depression may be enhanced by vancomycin.
Maltese: Depressjoni myocardial indotti bil-loppju jistgħu jiżdiedu bill-vankomiċin.
English: Intermittent therapy: initial dose of 30 mg/kg in the long-dwell, followed by 15 mg/kg every 3-5 days during the long-dwell (the second dose should be time-based on a blood level obtained 2-4 days after the initial dose, see section 4.4).
Maltese: Terapija intermittenti: id-doża inizjali ta' 30 mg/kg fil-long-dwell,segwit minn 15 mg/kg kull 3-5 ijiem matul il-long-dwell (it-tieni doża għandha tkun bbażata fuq il-ħin fuq il-livell tad-demm bbażata fuq ilħin miksuba 2-4 jiem wara l-bidu tad-doża, ara sezzjoni 4.4).
English: Hepatic impairment:
Maltese: Nefrotossiċità:
English: Vancomycin powder is made into a <solution for infusion> <or> <oral solution>.
Maltese: Jiġi magħmul trab vankomiċin <soluzzjoni għall-infużjoni><jew><soluzzjoni orali>.
English: Susceptible
Maltese: Suxxettibbilità
English: Vancomycin should not be administered intramuscularly due to the risk of necrosis at the site of administration.
Maltese: Il-Vankomiċin għandu jkun amministrat intramuskolarmentalment minħabba r-riskju tal-nekrosi fis-sit tal-amministrazzjoni.
English: You will be given Vancomycin by medical staff while you are in hospital.
Maltese: Inti ser tingħata vancomycin mill-istaff mediku waqt li inti fil isptar.
English: Renal impairment
Maltese: Reazzjonijiet marbuta mal-infużjoni
English: In addition, it impairs the permeability of the bacterial cell membrane and RNA synthesis.
Maltese: Barra minn hekk, tnaqqas il-permeabilità tal-membrana taċ-ċellula batterjali u tas-sintesi tal- RNA.
English: Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units.
Maltese: Vancomycin huwa antibijotiku glikopeptid triċikliċu li jinibixxi s-sintesi tal-ħajt taċ-ċellula fil-batterji sensittivi billi jeħel b'affinità għolja mat-terminu 'D-Alanyl-D aminotransferase ta' unitajiet prekursuri tal-ħajt taċ-ċelluli.
English: In seriously ill patients, a loading dose of 25-30 mg/kg of body weight can be used to facilitate rapid attainment of target trough serum vancomycin concentration.
Maltese: Fil-pazjenti morda serjament, id-doża tat-tagħbija ta' 25 - 30 mg/kg tal-piż tal-ġisem jista' jintuża biex jiffaċilita l-kisba rapida ta' l-inqas konċentrazzjoni mmirata ta' vankomiċin fis-serum .
English: The natural decrement of glomerular filtration with increasing age may lead to elevated vancomycin serum concentrations if dosage is not adjusted (see section 4.2).
Maltese: It-tnaqqis naturali tal- filtrazzjoni glomerulari biż-ieda fl-età jistgħu jwasslu għal konċentrazzjonijiet ta ' vankomiċin fis-serum elevati jekk id-doża ma tkunx aġġustata (ara sezzjoni 4.2).
English: On basis of in vitro, animal and limited human data, an AUC/MIC ratio of 400 has been established as a PK/PD target to achieve clinical effectiveness with vancomycin.
Maltese: Fuq il-bażi tad-data in vitro, annimali u data limitata mill-bniedem, ilproporzjon tal-AUC/MIC ta' 400 ġiet stabbilita bħala mira PK/PD iexb jintlaħqu effettività klinika bilvankomiċin.
English: After intraperitoneal administration of 30 mg/kg serum levels of approximately 10 mg/l are reached.
Maltese: Wara s-somministrazzjoni intraperitonali ta ' 30 mg/kg huma jilħqu livelli tasserum ta ' madwar 10 mg/l.