FrancophonIA/ELRC3.0 huggingface dataset:
English: Okrido is a medicine that contains the active substance prednisolone sodium phosphate.
Estonian: Okrido on ravim, mis sisaldab toimeainena prednisoloonnaatriumfosfaati.
English: Based on an evaluation of the currently available data and the scientific discussion within the Committee, the CHMP concluded that, based on the data submitted, Okrido is expected to produce comparable levels of the active substance in the body to the reference medicine.
Estonian: Olemasolevate andmete hindamise ja inimravimite komitees aset leidnud arutelude alusel järeldas inimravimite komitee, et esitatud andmete põhjal saavutatakse Okrido kasutamisel organismis sarnane toimeainesisaldus nagu võrdlusravimi korral.
English: It is available as an oral solution (6mg/ml).
Estonian: Okridot turustatakse suukaudse lahusena (6 mg/ml).
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) concluded that the benefits of Okrido outweighs its risks, and the marketing authorisation granted in the United Kingdom can be recognised in other Member States of the EU.
Estonian: Euroopa Ravimiameti inimravimite komitee järeldas, et Okrido kasulikkus ületab sellega kaasnevad riskid ja et Ühendkuningriigis antud müügiluba võivad tunnustada teised Euroopa Liidu liikmesriigid.
English: The grounds for the referral were that sufficient data had not been provided to show that Okrido produces comparable levels of the active substance in the body to Prednisolone 5 mg soluble tablets by Sovereign.
Estonian: Esildise põhjus oli Madalmaade arvamus, et ei ole esitatud piisavalt andmeid tõendamaks, et Okrido manustamisel saavutatakse samasugune toimeainesisaldus veres nagu ravimifirma Sovereign Prednisolone 5 mg lahustuvate tablettide manustamisel.
English: The active substance in Okrido, prednisolone sodium phosphate, belongs to a group of medicines called glucocorticoids, which are substances that help to reduce inflammation.
Estonian: Okrido toimeaine prednisoloonnaatriumfosfaat kuulub ravimite rühma, mida nimetatakse glükokortikoidideks.
English: Okrido is a generic medicine based on a ‘reference medicine' already authorised in the EU.
Estonian: Okrido on geneeriline ravim, mille võrdlusravimil on müügiluba Euroopa Liidus.
English: The reference medicine was Prednisolone 5 mg soluble tablets by Sovereign.
Estonian: Okrido võrdlusravim oli Prednisolone 5 mg lahustuvad tabletid (ravimifirmalt Sovereign).
English: The CHMP therefore concluded that the benefits of Okrido outweigh its risks, and therefore the marketing authorisation for Okrido should be granted in all concerned Member States.
Estonian: Seetõttu otsustas inimravimite komitee, et Okrido kasulikkus on suurem kui sellega kaasnevad riskid, ja soovitas anda kõigis asjaomastes liikmesriikides ravimi müügiloa.
English: Further information on Metacam can be found on the Agency's website: ema.europa.eu/Find medicine/Veterinary medicines/European public assessment reports.
Estonian: Lisateave Metacami kohta on ameti veebilehel: ema.europa.eu/Find medicine/Veterinary medicines/European public assessment reports.
English: The European Medicines Agency decided that Metacam's benefits are greater than its risks and that it can be authorised for use in the EU.
Estonian: Euroopa Ravimiamet otsustas, et Metacami kasulikkus on suurem kui sellega kaasnevad riskid ja et ravimi kasutamise saab Euroopa Liidus heaks kiita.
English: In very rare cases, they may be serious or fatal.
Estonian: Väga harvadel juhtudel võivad kõrvalnähud olla rasked või surmavad.
English: Other information about Metacam
Estonian: Muu teave Metacami kohta
English: Metacam received a marketing authorisation valid throughout the EU for Metacam on 7 January 1998.
Estonian: Metacami müügiluba, mis kehtib kogu Euroopa Liidus, anti 7. jaanuaril 1998.
English: Metacam (meloxicam)
Estonian: Metacam (meloksikaam)
English: These side effects occur usually within the first week of treatment and are generally transient (temporary).
Estonian: Need kõrvalnähud esinevad tavaliselt esimesel ravinädalal ning on üldiselt ajutised.
English: The withdrawal period for meat is 5 days.
Estonian: Liha keeluaeg on 5 päeva.
English: What is Metacam and what is it used for?
Estonian: Mis on Metacam ja milleks seda kasutatakse?
English: For the 20 mg/ml and 40 mg/ml solution for injection the meat withdrawal period is 5 days and for the 15 mg/ml oral suspension it is 3 days.
Estonian: 20 mg/ml ja 40 mg/ml süstelahuse korral on liha keeluaeg 5 päeva ning 15 mg/ml suukaudse suspensiooni korral 3 päeva.
English: All sows also received antibiotics.
Estonian: Kõik emised said ka antibiootikume.
English: A temporary swelling at the injection site can occur but resolves without intervention.
Estonian: Süstekohal võib tekkida ajutine turse, kuid see kaob sekkumiseta.
English: The 40 mg/ml solution for injection should not be handled by pregnant women or women attempting to conceive as accidental self-injection may affect the development of the baby in the womb.
Estonian: 40 mg/ml süstelahust ei tohi käsitseda rasedad või rasestuda soovivad naised, sest ravimi juhuslik enesesüstimine võib kahjustada loote arengut emakas.
English: The main measure of effectiveness was the assessment of pain score at various time points up to 20 hours post-surgery.
Estonian: Efektiivsuse põhinäitaja oli valuskoor eri ajahetkedel kuni 20 tundi pärast operatsiooni.
English: For further information about using Metacam, see the package leaflet or contact your veterinarian or pharmacist.
Estonian: Kui vajate Metacamiga toimuva ravi kohta lisateavet, lugege palun pakendi infolehte või pöörduge oma veterinaararsti või apteekri poole.
English: These side effects resolve once treatment has stopped.
Estonian: Need kõrvalnähud kaovad pärast ravi lõppu.
English: In cattle, pigs and horses in very rare cases anaphylactoid reactions which may be serious (including fatal) may occur and should be treated symptomatically.
Estonian: Veistel, sigadel ja hobustel võib väga harvadel juhtudel esineda anafülaktoidseid reaktsioone, mis võivad olla rasked (sh surmavad) ja vajavad sümptomaatilist ravi.
English: What are the risks associated with Metacam?
Estonian: Mis riskid Metacamiga kaasnevad?
English: The product is not authorised to use in horses producing milk for human consumption.
Estonian: Ravimit ei tohi kasutada hobustel, kelle piima tarvitatakse inimtoiduks.
English: Metacam is an anti-inflammatory medicine used in cattle, pigs, horses, dogs, cats and guinea pigs.
Estonian: Metacam on põletikuvastane ravim, mida kasutatakse veistel, sigadel, hobustel, koertel, kassidel ja merisigadel.
English: This summary was last updated in March 2018.
Estonian: Kokkuvõtte viimane uuendus: 03-2018.
English: If the product is accidentally swallowed or self-injected by a person, the advice of a doctor should be sought immediately.
Estonian: Ravimi juhuslikul allaneelamisel või enesesüstimisel tuleb viivitamatult pöörduda arsti poole.
English: The studies with chronic locomotor disorders showed Metacam to be effective.
Estonian: Krooniliste lokomotoorikahäirete uuringutes tõendati Metacami efektiivsust.
English: The main measure of effectiveness was blood levels of the stress hormone cortisol 30 minutes after surgery.
Estonian: Efektiivsuse põhinäitaja oli vere kortisoolisisaldus (kortisool on stressihormoon) 30 minutit pärast operatsiooni.
English: People who are hypersensitive (allergic) to NSAIDs should avoid contact with Metacam.
Estonian: Inimesed, kes on mittesteroidsete põletikuvastaste ravimite suhtes ülitundlikud (allergilised), peavad kokkupuudet Metacamiga vältima.
English: Injections may be into a vein, muscles or under the skin.
Estonian: Süsti tohib teha veeni, lihasesse või naha alla.
English: An overview of Metacam and why it is authorised in the EU
Estonian: Metacami ülevaade ja Euroopa Liidus heakskiitmise põhjused
English: 46 cats received Metacam oral suspension for 28 days whilst 48 cats received placebo oral suspension.
Estonian: 46 kassile manustati 28 päeva jooksul Metacami suukaudset suspensiooni ja 48 kassile platseebo suukaudset suspensiooni.
English: Metacam contains meloxicam, which belongs to a class of medicines called non-steroidal antiinflammatory drugs (NSAIDs).
Estonian: Metacam sisaldab meloksikaami, mis kuulub mittesteroidsete põletikuvastaste ravimite (NSAID) klassi.
English: Metacam was effective in improving mobility and reducing pain from day 0-14 compared to the control group.
Estonian: Metacam oli 0-14 päeva jooksul liikuvuse parandamisel ja valu leevendamisel kontrollrühmaga võrreldes efektiivne.
English: The withdrawal period is 15 days for meat and 5 days for milk.
Estonian: Liha keeluaeg on 15 päeva ja piima keeluaeg on 5 päeva.
English: How is Metacam used?
Estonian: Kuidas Metacami kasutatakse?
English: The main measure of effectiveness was based on clinical signs of diarrhoea and the animal's behaviour, feed intake, body temperature, respiratory rate, heart rate and general condition.
Estonian: Efektiivsuse põhinäitajad olid kõhulahtisuse kliinilised sümptomid ja loomade käitumine, sööda tarbimine, kehatemperatuur, hingamissagedus, südame löögisagedus ja üldseisund.
English: As prostaglandins are substances that trigger inflammation, pain, exudation (fluid that leaks out of blood vessels during an inflammation) and fever, meloxicam reduces these signs of disease.
Estonian: Et prostaglandiinid tekitavad põletikku, valu, eksudatsiooni (põletiku korral veresoontest erituv vedelik) ja palavikku, vähendab meloksikaam neid haigussümptomeid.
English: In addition slight urticaria (itchy rash) and diarrhoea can occur which are both typical side effects of NSAIDs and which resolve by themselves.
Estonian: Lisaks võib esineda kerget urtikaariat (sügelev lööve) ja kõhulahtisust - mõlemad on NSAIDide tüüpilised kõrvalnähud ja mööduvad iseenesest.
English: The study showed Metacam to be effective in reducing pain associated with the dehorning procedure.
Estonian: Uuringust nähtus, et Metacam oli nudistamisprotseduuriga seotud valu leevendamisel efektiivne.
English: Metacam contains the active substance meloxicam.
Estonian: Metacam sisaldab toimeainena meloksikaami.
English: The withdrawal period is the time allowed after administration of the medicine before an animal can be slaughtered and the meat used for human consumption.
Estonian: Keeluaeg on alates ravimi manustamisest arvestatav aeg, mille jooksul ei tohi looma tappa ega tema liha inimtoiduks tarvitada.
English: The main measure of effectiveness was based on their general condition, milk appearance and signs of udder inflammation.
Estonian: Efektiivsuse põhinäitaja tugines loomade üldseisundile, piimaeritusele ja udarapõletiku sümptomitele.
English: In addition to antibiotic therapy animals either received a single injection of Metacam or flunixin (another NSAID) for up to 5 days.
Estonian: Loomadele tehti kuni 5 ööpäeval lisaks antibiootikumravile kas ühekordne Metacami või fluniksiini (samuti NSAID) süst.
English: The effectiveness of Metacam injection was studied in 209 pigs with non-infectious locomotor disorders.
Estonian: Metacami süsti efektiivsust uuriti 209 mittenakkuslike lokomotoorikahäiretega seal.
English: In pigs, Metacam is used in non-infectious locomotor disorders (diseases that affect the ability to move) to reduce lameness and inflammation, relieve post-operative pain associated with minor soft tissue surgery such as castration, and for supportive therapy together with antibiotics in the treatment of diseases that occur after farrowing (giving birth) such as puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome, a bacterial infection of the udder and/or the womb).
Estonian: Sigadel kasutatakse Metacami mittenakkuslike lokomotoorikahäirete (liikumisvõimet takistavad haigused) korral lonkamise ja põletiku vähendamiseks, väiksemate pehmekoe operatsioonide, nt kastreerimisjärgse valu vähendamiseks ja poegimisjärgsete haiguste, näiteks poegimisjärgse sepsise ja tokseemia (mastiidi-metriidi-agalaktia sündroom, udara ja/või emaka bakteriaalne infektsioon) toetavaks raviks koos antibiootikumidega.
English: All calves were given oral rehydration therapy and antibiotics.
Estonian: Kõik vasikad said suukaudset rehüdratsioonravi ja antibiootikume.
English: Metacam 5 mg/ml solution for injection was comparable to carprofen in reducing post-operative pain in cats following ovariohysterectomy.
Estonian: Metacami 5 mg/ml süstelahus oli kassidel munasarjade ja emaka eemaldamise operatsiooni järgse valu vähendamisel karprofeeniga võrreldav.
English: Horses
Estonian: Hobused
English: A laboratory study in 30 guinea pigs compared Metacam oral suspension with placebo given about 45 minutes before surgical castration and on each of the following two days.
Estonian: Laboriuuringus võrreldi 30 meriseal Metacami suukaudset suspensiooni platseeboga, manustatuna ligikaudu 45 minutit enne kirurgilist kastreerimist ja kahel järgneval päeval.
English: In one study three different meloxicam treatment schedules for acute locomotor disorders were compared.
Estonian: Ühes uuringus võrreldi ägedate lokomotoorikahäirete kolme erinevat meloksikaami raviskeemi.
English: In cattle and pigs, Metacam is well tolerated; only a slight temporary swelling at the injection site following subcutaneous administration was observed in most cattle studied in laboratory conditions.
Estonian: Veised ja sead taluvad Metacami hästi: enamikul laboritingimustes uuritud veistel täheldati pärast ravimi subkutaanset manustamist üksnes kerget mööduvat turset süstekohal.
English: Metacam injection in cattle significantly improved clinical signs of respiratory infection and reduced fever compared with antibiotics alone.
Estonian: Veistel leevendas Metacami süst oluliselt respiratoorse infektsiooni kliinilisi sümptomeid ja alandas palavikku võrreldes ainult antibiootikumidega.
English: A study in 187 sows with puerperal septicaemia and toxaemia compared Metacam with flunixin (another NSAID).
Estonian: 187 poegimisjärgse sepsise ja tokseemiaga emise uuringus võrreldi Metacami fluniksiiniga (samuti NSAID).
English: Metacam treated piglets had significantly reduced blood cortisol levels (which indicates that they were exposed to lower levels of stress) 30 minutes after castration compared with the control group.
Estonian: Metacamiga ravitud põrsastel oli 30 minutit pärast kastreerimist võrreldes kontrollrühmaga vere kortisoolisisaldus oluliselt vähenenud (mis viitab sellele, et nende stressitase oli madalam).
English: Another study in cattle involved 501 calves with diarrhoea.
Estonian: Teises veiste uuringus uuriti 501 kõhulahtisusega vasikat.
English: 326 cattle received Metacam given as an injection together with antibiotic therapy whilst 326 cattle received a placebo (dummy) injection and antibiotic therapy.
Estonian: 326 veisele süstiti Metacami ja manustati antibiootikume ning 326 veisele süstiti platseebot (näiv ravim) ja manustati antibiootikume.
English: Metacam oral suspension was given for 5 days and compared with ketoprofen (another NSAID).
Estonian: Kassidele manustati 5 päeval Metacami suukaudset suspensiooni ning seda võrreldi ketoprofeeniga (samuti NSAID).
English: In very rare cases anaphylactoid reactions and elevated liver enzymes have been reported.
Estonian: Väga harvadel juhtudel on täheldatud anafülaktoidseid reaktsioone ja maksaensüümide sisalduse suurenemist.
English: Metacam improved lameness in horses at day 14 and at the final follow-up examination 2-4 days later than the vedaprofen treated group whilst the second study showed Metacam to be comparable to vedaprofen.
Estonian: 14. päeval ja 2-4 päeva hiljem toimunud viimases järelkontrollis ilmnes, et Metacam vähendas hobuste lonkamist efektiivsemalt kui vedaprofeen; teises uuringus oli Metacam vedaprofeeniga võrreldav.
English: The study showed that the dogs receiving meloxicam injection followed by oral doses had the best results in improving mobility based on a standard scoring system.
Estonian: Uuringust nähtus, et standardse hindamissüsteemi alusel hinnatuna paranes liikuvus kõige paremini koertel, kellele süstiti meloksikaami ja seejärel manustati Metacami suukaudselt.
English: What benefits of Metacam have been shown in studies?
Estonian: Milles seisneb uuringute põhjal Metacami kasulikkus?
English: Metacam significantly reduced lameness with 49% of the Metacam treated pigs with no lameness compared with 27% of the pigs which received the placebo treatment.
Estonian: Metacam vähendas oluliselt lonkamist: sigu, kes ei longanud, oli Metacami uuringurühmas 49% ja platseeborühmas 27%.
English: In dogs and cats, occasional side effects of Metacam are those seen with NSAIDs, such as loss of appetite, vomiting, diarrhoea, blood appearing in the stools, apathy (lack of vitality) and kidney failure.
Estonian: Koertel ja kassidel esinevad Metacamiga aeg-ajalt NSAIDide tüüpilised kõrvalnähud, näiteks isutus, oksendamine, kõhulahtisus, veriroe, apaatia (loidus) ja neerupuudulikkus.
English: Metacam oral suspension was comparable to ketoprofen in improving lameness and pain.
Estonian: Metacami suukaudne suspensioon oli lonkamise ja valu vähendamisel võrreldav ketoprofeeniga.
English: Meloxicam acts by blocking an enzyme called cyclooxygenase which is involved in the production of prostaglandins.
Estonian: Meloksikaam blokeerib prostaglandiinide tekkes osaleva ensüümi tsüklooksügenaasi.
English: Guinea pigs treated with Metacam had significantly higher frequency of feed intake (240 events) over three days, indicating that their pain was reduced, compared with guinea pigs given placebo (207 events).
Estonian: Metacamiga ravitud merisead sõid kolme päeva jooksul oluliselt sagedamini (240 korral) kui platseebot saanud merisead (207 korral), mis viitab sellele, et Metacam vähendas merisigadel valu.
English: Metacam injection was studied in 76 cats undergoing ovariohysterectomy.
Estonian: Metacami süsti uuriti 76 kassil, kellel eemaldati munasarjad ja emakas.
English: Metacam injection was compared with vedaprofen (another NSAID) for pain relief associated with equine colic in 269 horses.
Estonian: Metacami süsti võrreldi vedaprofeeniga (samuti NSAID) voolmete leevendamisel 269 hobusel.
English: Metacam injection in combination with antibiotic therapy was investigated in a study involving 240 cattle with acute mastitis.
Estonian: Metacami süsti ja antibiootikumravi kombinatsiooni toimet vaadeldi 240 ägeda mastiidiga veise uuringus.
English: How does Metacam work?
Estonian: Kuidas Metacam toimib?
English: Metacam injection was studied in 60 calves with one group receiving Metacam and local anaesthetic and one group receiving a placebo injection and local anaesthetic prior to dehorning.
Estonian: Metacami süsti toimet uuriti 60 vasikal - ühele rühmale manustati enne nudistamist Metacami ja lokaalanesteetikumi ning teisele rühmale süstiti platseebot ja manustati lokaalanesteetikumi.
English: Pigs either received Metacam or a placebo injection.
Estonian: Sigadele tehti kas Metacami või platseebosüst.
English: Cats
Estonian: Kassid
English: The effectiveness of Metacam injection, in combination with antibiotic therapy, was studied in cattle with acute respiratory infection.
Estonian: Metacami süsti ja antibiootikumravi kombinatsiooni efektiivsust uuriti ägeda respiratoorse infektsiooniga veistel.
English: The formulation and dose to use depends on the animal species, its bodyweight and the condition being treated.
Estonian: Kasutatav ravimvorm ja annus olenevad loomaliigist, kehamassist ja ravitavast seisundist.
English: Metacam oral suspension was studied for treatment of musculoskeletal disorders associated with lameness in two studies and compared to treatment with vedaprofen.
Estonian: Metacami suukaudset suspensiooni uuriti lonkamisega seostatavate luu- ja lihaskonna vaevuste ravis kahes uuringus ning seda võrreldi vedaprofeenraviga.
English: Metacam can only be obtained with a prescription.
Estonian: Metacam on retseptiravim.
English: Dogs
Estonian: Koerad
English: A number of studies were conducted in dogs with acute and chronic locomotor disorders with both oral and injectable Metacam.
Estonian: Ägedate ja krooniliste lokomotoorikahäiretega koertel tehti mitu uuringut nii suukaudse kui ka süstitava Metacamiga.
English: In cattle, Metacam is used together with antibiotics, to reduce clinical signs such as fever and inflammation in acute (short-term) respiratory infection (infection of the lungs and airways).
Estonian: Veistel kasutatakse Metacami koos antibiootikumidega ägeda (lühiajalise) respiratoorse infektsiooni (kopsude ja hingamisteede nakkus) kliiniliste sümptomite, näiteks palaviku ja põletiku vähendamiseks.
English: 37 cats received Metacam and 39 cats received carprofen (another NSAID) by subcutaneous (under the skin) injection immediately after receiving anaesthesia.
Estonian: Vahetult pärast anesteesiat süstiti 37 kassile subkutaanselt (naha alla) Metacami ja 39 kassile karprofeeni (samuti NSAID).
English: In horses, Metacam is used to relieve pain associated with colic (abdominal pain) and to alleviate inflammation and pain in both acute and chronic (long-term) musculo-skeletal disorders (disorders affecting the muscles and bones).
Estonian: Hobustel kasutatakse Metacami voolmete (kõhuvalu) ning põletiku ja valu leevendamiseks nii ägedate kui ka krooniliste (pikaajaliste) luu- ja lihaskonna vaevuste korral.
English: In dogs, Metacam is used to reduce post-operative pain and inflammation following orthopaedic (e.g. fracture operation) and soft tissue surgery.
Estonian: Koertel kasutatakse Metacami valu ja põletiku leevendamiseks pärast ortopeedilisi operatsioone (nt luumurru operatsioon) ja pehmekoe operatsioone.
English: In cats, Metacam is used to reduce post-operative pain and inflammation after ovariohysterectomy (spay operation), orthopaedic and minor soft tissue surgery.
Estonian: Kassidel kasutatakse Metacami valu ja põletiku leevendamiseks pärast steriliseerimist (munasarjade ja emaka eemaldamist), ortopeedilisi operatsioone ja väiksemaid pehmekoe operatsioone.
English: In very rare cases, in dogs, haemorrhagic diarrhoea (bloody diarrhoea), haematemesis (vomiting blood) or gastrointestinal ulceration (ulcer in the gut) have been reported.
Estonian: Väga harvadel juhtudel on koertel täheldatud hemorraagilist (verist) kõhulahtisust, hematemeesi (veriokse) ja seedetrakti haavandeid.
English: Metacam was comparable to flunixin in treating signs of infection and inflammation associated with puerperal septicaemia and toxaemia.
Estonian: Metacam oli poegimisjärgse sepsise ja tokseemiaga seostatava infektsiooni ja põletiku nähtude ravis võrreldav fluniksiiniga.
English: Metacam is available as an oral (taken by mouth) suspension, a solution for injection and chewable tablets.
Estonian: Metacami turustatakse suukaudse suspensioonina, süstelahusena ja närimistablettidena.
English: In very rare cases loss of appetite, lethargy, abdominal pain and colitis (inflammation of the lower part of the gut) have been reported.
Estonian: Väga harvadel juhtudel on täheldatud isutust, loidust, kõhuvalu ja koliiti (jämesoole ja pärasoole põletik).
English: Calves treated with Metacam showed a significant improvement in their signs of diarrhoea compared with the control group.
Estonian: Metacamiga ravitud vasikate kõhulahtisuse sümptomid vähenesid oluliselt võrreldes kontrollrühmaga.
English: Animals received either Metacam injection or a placebo injection.
Estonian: Vasikatele tehti kas Metacami süst või platseebosüst.
English: In guinea pigs, Metacam is used to reduce post-operative pain after soft tissue surgery such as castration.
Estonian: Merisigadel kasutatakse Metacami valu leevendamiseks pärast pehmekoe operatsioone, näiteks pärast kastreerimist.
English: Both medicines were comparable in reducing pain associated with equine colic.
Estonian: Mõlemad ravimid leevendasid hobustel voolmeid samal määral.
English: A study was carried out in cats with acute musculo-skeletal disorders.
Estonian: Ühes uuringus uuriti ägedate luu- ja lihaskonna vaevustega kasse.
English: Why is Metacam approved in the EU?
Estonian: Metacami Euroopa Liidus heakskiitmise põhjused