FrancophonIA/ELRC3.0 huggingface dataset:
English: Approximately 77% of patients had recurrent ischaemia, approximately 70% had dynamic ECG changes or elevated cardiac biomarkers, approximately 28% had diabetes and approximately 99% of patients underwent angiography within 72 hours.
Slovenian: Približno 77 % bolnikov je imelo ponavljajočo ishemijo, približno 70 % je imelo dinamične spremembe EKG ali povišane srčne biološke označevalce, približno 28 % jih je imelo diabetes in približno 99 % bolnikov je prestalo angiografijo v 72 urah.
English: Bivalirudin is intended for short-term administration and therefore no data on the long-term carcinogenic potential of bivalirudin are available.
Slovenian: Bivalirudin je namenjen kratkotrajnemu dajanju in zato ni podatkov o dolgotrajnem karcinogenem potencialu bivalirudina.
English: Clinical trials in a small number of patients have provided limited information about the use of Angiox in patients with HIT/HITTS.
Slovenian: Klinična preskušanja na majhni skupini bolnikov nudijo omejene podatke o uporabi Angioxa pri bolnikih s HIT/HITTS.
English: If you get any of the following, potentially serious, side effects:
Slovenian: Če opazite katerikoli izmed naslednjih, morebitno resnih, neželenih učinkov:
English: This dosing regimen is required to achieve and maintain the plasma concentration required for effective ischaemic protection during PCI.
Slovenian: Ta režim odmerjanja je potreben za doseganje in vzdrževanje plazemske koncentracije, ki je potrebna za učinkovito ishemično zaščito med posegom PCI.
English: Bivalirudin does not bind to plasma proteins (other than thrombin) or to red blood cells.
Slovenian: Bivalirudin se ne veže na beljakovine plazme (razen trombina) ali rdeče krvne celice.
English: Your treatment with Angiox will be supervised by a doctor.
Slovenian: Vaše zdravljenje z zdravilom Angiox bo nadziral zdravnik.
English: See section 6.2 for the summary of compatible and incompatible concentrations of these compounds.
Slovenian: Glejte poglavje 6.2 za povzetek združljivih in nezdružljivih koncentracij omenjenih učinkovin.
English: In order to ensure the correct use of Angiox and to avoid medication errors, the MAH shall ensure that all prescribers who are expected to prescribe/use Angiox are provided with training on dosing and administration.
Slovenian: Da bi zagotovili pravilno uporabo zdravila Angiox in se izognili napakam pri zdravljenju, mora MAH poskrbeti, da bodo vsi zdravnikih, za katere se pričakuje da bodo predpisovali/uporabljali zdravila Angiox, usposobljeni za odmerjanje in dajanje.
English: • if bleeding occurs (if this happens, treatment with Angiox will be stopped).
Slovenian: • če se pojavi krvavitev (v tem primeru je potrebno zdravljenje z zdravilom Angiox prekiniti).
English: Bleeding Definitions
Slovenian: Definicije krvavitev
English: Angiox should not be used during pregnancy unless the clinical condition of the woman requires treatment with bivalirudin.
Slovenian: Zdravila Angiox ne uporabljajte med nosečnostjo, razen če klinično stanje ženske zahteva zdravljenje z bivaluridinom.
English: The bioavailability of bivalirudin for intravenous use is complete and immediate.
Slovenian: Biološka uporabnost bivalirudina, danega intravensko, je popolna in takojšnja.
English: • Allergic reactions,- are uncommon (may affect up to 1 in 100 people) and usually not serious but can become severe under some circumstances, and in rare cases may be fatal due to low blood pressure (shock).
Slovenian: • Alergijske reakcije so občasne (pojavijo se lahko pri največ 1 od 100 bolnikov) in običajno niso resne, lahko pa postanejo resne v določenih pogojih, v redkih primerih so lahko smrtne zaradi nizkega krvnega tlaka (šok).
English: Death
Slovenian: Smrt
English: Acute cardiac events
Slovenian: Akutni srčni dogodki
English: All 5 events were associated with additional cardiac procedures employing heparin anticoagulation (n=3) or with infections (n=2).
Slovenian: Vseh 5 dogodkov je bilo povezanih z dodatnimi postopki na srcu z uporabo antikoagulacije s heparinom (n = 3) ali z okužbami (n = 2).
English: In all clinical studies bleeding data were collected separately from adverse reactions and are summarised in Table 6 together with the bleeding definitions used for each study.
Slovenian: V vseh kliničnih študijah so bili podatki o krvavitvah pridobljeni ločeno od neželenih učinkov ter so predstavljeni v preglednici 6, skupaj z definicijami krvavitev uporabljenih pri vsaki študiji.
English: Where insufficient ACT increase is observed, the possibility of medication error should be considered, for example inadequate mixing of Angiox or intravenous equipment failures.
Slovenian: Kjer ni opaziti zadostnega zvečanja ACT, je treba upoštevati možnosti napake pri dajanju zdravila, na primer nezadostno mešanje zdravila Angiox ali okvare na intravenski opremi.
English: Angiox should not be used during pregnancy, unless clearly necessary.
Slovenian: Zdravila Angiox ne uporabljajte med nosečnostjo, razen če ni nujno potrebno.
English: • if you have been treated before with medicines similar to Angiox (e.g. lepirudin).
Slovenian: • če ste se v preteklosti zdravili z zdravili, podobnimi zdravilu Angiox (npr. lepirudin)
English: Pharmacodynamic models indicated that this effect is due to a higher baseline ACT in neonates and infants than in older children.
Slovenian: Farmakodinamični modeli kažejo, da je ta učinek posledica večje izhodiščne vrednosti ACT pri novorojenčkih in dojenčkih kot pri starejših otrocih.
English: In clinical study TMC-BIV-07-01, the pharmacodynamic response as measured by ACT was consistent with adult studies.
Slovenian: V klinični študiji TMC-BIV-07-01 je bil farmakodinamični odziv, izmerjen s pomočjo ACT, skladen s študijami pri odraslih.
English: Instructions for preparation
Slovenian: Navodila za pripravo
English: High risk patient characteristics of the ACUITY population that mandated angiography within 72 hours were balanced across the three treatment arms.
Slovenian: Karakteristike bolnikov visokim tveganjem v populaciji študije ACUITY, zaradi katerih je bila potrebna angiografija v 72 urah, so bile proporcionalno razdeljene v vse tri krake zdravljenja.
English: The corresponding clearance is about 3.4  0.5 ml/min/kg.
Slovenian: Ustrezen očistek je približno 3,4 ± 0,5 ml/min/kg.
English: ACT values 5 minutes after bivalirudin bolus average 365 +/- 100 seconds.
Slovenian: Vrednost ACT 5 minut po bolusu bivalirudina je povprečno 365 +/- 100 sekund.
English: You can also report side effects directly via the national reporting system listed in Appendix V.
Slovenian: O neželenih učinkih lahko poročate tudi neposredno na nacionalni center za poročanje, ki je naveden v Prilogi V.
English: Reconstituted and diluted product should be thoroughly mixed prior to administration.
Slovenian: Rekonstituirano in razredčeno zdravilo je treba pred uporabo temeljito zmešati.
English: • Haematoma (bruising)
Slovenian: • hematom (modrica)
English: Antithrombotics are medicines which prevent the formation of blood clots (thrombosis).
Slovenian: Antitrombotiki so zdravila, ki preprečujejo tvorjenje krvnih strdkov (tromboza).
English: Toxicity in animals upon repeated or continuous exposure (1 day to 4 weeks at exposure levels of up to 10 times the clinical steady state plasma concentration) was limited to exaggerated pharmacological effects.
Slovenian: Toksičnost pri živalih po večkratni ali neprekinjeni izpostavljenosti (1 dan do 4 tedne pri stopnji izpostavljenosti do 10-kratne plazemske koncentracije v kliničnem stanju dinamičnega ravnovesja) je bila omejena na povečane farmakološke učinke.
English: • Reperfusion injury (no or slow reflow): impaired flow in the heart arteries after they have been reopened
Slovenian: • reperfuzija (ni pretoka ali zmanjšan pretok): moten pretok v srčnih žilah potem, ko so bile
English: The ACT increased in all patients - from neonates to older children as well as adults- with increasing bivalirudin concentrations.
Slovenian: ACT se je pri vseh bolnikih povečal, od novorojenčkov do starejših otrok ter odraslih, z večanjem koncentracij bivalirudina.
English: Elimination follows a first order process with a terminal half-life of 25  12 minutes in patients with normal renal function.
Slovenian: Izločanje sledi procesu prve stopnje s končno razpolovno dobo 25 ± 12 minut pri bolnikih z normalno ledvično funkcijo.
English: If you have kidney problems, the dose of Angiox may need to be reduced.
Slovenian: Če imate težave z ledvicami, bo morda treba odmerek zdravila Angiox zmanjšati.
English: • Anaemia (a low blood cell count)
Slovenian: • anemija (majhno število krvnih celic)
English: • Bleeding and bruising at the puncture site (after PCI treatment) may be painful.
Slovenian: • Krvavitev in podplutba na mestu aplikacije (po izvedeni PCI), ki je lahko boleča.
English: The bolus dose should not be changed from the posology described under ACS or PCI above.
Slovenian: Bolusnega odmerka ne bi smeli spreminjati glede na odmerjanje, opisano pri AKS ali PCI zgoraj.
English: Thrombotic (9/110, 8.2%) and major bleeding events (2/110, 1.8%) were observed in the study.
Slovenian: V študiji so opazili trombotične (9/110, 8,2 %) dogodke in dogodke večjih krvavitev (2/110, 1,8 %).
English: Angiox is used to treat patients:
Slovenian: Zdravilo Angiox se uporablja za zdravljenje bolnikov:
English: Thus, bivalirudin initially acts as a complete non-competitive inhibitor of thrombin, but transitions over time to become a competitive inhibitor enabling initially inhibited thrombin molecules to interact with other clotting substrates and to coagulation if required.
Slovenian: Zato bivalirudin sprva deluje kot popolni nekompetitivni inhibitor trombina, sčasoma pa postane kompetitivni inhibitor, s čimer omogoči sprva inhibiranim molekulam trombina, da medsebojno delujejo z drugimi substancami strjevanja in omogočijo koagulacijo, če je potrebno.
English: The dose given depends on your weight and on the kind of treatment you are being given.
Slovenian: Odmerek, ki ga boste prejeli, je odvisen od vaše telesne mase in vrste zdravljenja, ki ste ga deležni.
English: Following angiographic assessment, patients were triaged to either medical management (33%), PCI (56%) or CABG (11%).
Slovenian: Po angiografski oceni so bolnike triažirali v zdravljenje z zdravili (33 %), v skupino za PCI (56 %) ali CABG (11 %).
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Slovenian: Imetnik dovoljenja za promet z zdravilom bo izvedel zahtevane farmakovigilančne aktivnosti in ukrepe, podrobno opisane v sprejetem RMP, predloženem v modulu 1.8.2 dovoljenja za promet z zdravilom, in vseh naslednjih sprejetih posodobitvah RMP.
English: If, after this, you then need percutaneous coronary intervention (PCI) treatment, the dosage will be increased to:
Slovenian: Če bi po tem potrebovali zdravljenje s perkutano koronarno intervencijo (PCI), bo odmerek povečan na:
English: Pharmacokinetic studies indicate that hepatic metabolism of bivalirudin is limited, therefore the safety and efficacy of bivalirudin have not been specifically studied in patients with hepatic impairment.
Slovenian: Farmakokinetične študije kažejo, da je jetrna presnova bivalirudina omejena, zato varnost in učinkovitost bivalirudina pri bolnikih z jetrno okvaro nista bili posebej preučeni.
English: Bivalirudin inhibits each of these thrombin effects.
Slovenian: Bivalirudin inhibira vse te učinke trombina.
English: If you get any of the following, (potentially less serious), side effects:
Slovenian: Če pride do naslednjih (potencialno manj resnih) neželenih učinkov:
English: Other frequently reported adverse events were decreased pedal pulse, catheter site haemorrhage, abnormal pulse, and nausea (8.2%, 7.3%, 6.4% and 5.5%, respectively).
Slovenian: Drugi neželeni dogodki, o katerih so pogosto poročali, so bili oslabljen pulz na hrbtišču stopala, krvavitev na mestu vstavitve katetra, nenormalen pulz in slabost (8,2 %, 7,3 %, 6,4 % oz. 5,5 %).
English: (For full information on posology see section 4.2 of SmPC)
Slovenian: (Za popolne informacije o odmerjanju glejte poglavje 4.2 SmPC)
English: For instructions for monitoring acute stent thrombosis, see section 4.4. d. Section 4.4 describes precautions for INR monitoring when bivalirudin is co-administered with warfarin.
Slovenian: Za navodila glede spremljanja akutne tromboze stenta glejte tudi poglavje 4.4. d. Poglavje 4.4 opisuje previdnostne ukrepe za spremljanje INR, ko se bivalirudin daje sočasno z varfarinom.
English: Combined use of anti-coagulant medicinal products can be expected to increase the risk of bleeding (see section 4.5).
Slovenian: Pri kombinirani uporabi zdravil proti koagulaciji se lahko pričakuje povečanje tveganja krvavitev (glejte poglavje 4.5).
English: A total of 92.9% of patients treated underwent primary PCI as their primary management strategy.
Slovenian: Primarna PCI je bila za 92,9 % bolnikov primarna strategija zdravljenja.
English: Treatment-emergent positive bivalirudin antibodies are rare and have not been associated with clinical evidence of allergic or anaphylactic reactions.
Slovenian: Pozitivna protitelesa proti bivalirudinu zaradi zdravljenja so redka in niso povezana s kliničnimi dokazi alergijske ali anafilaktične reakcije.
English: Pharmacokinetics have been evaluated in elderly patients as part of a renal pharmacokinetic study.
Slovenian: Farmakokinetika je bila pri starejših ovrednotena kot del ledvične farmakokinetične študije.
English: What Angiox is and what it is used for What you need to know before you use Angiox
Slovenian: Kaj je zdravilo Angiox in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Angiox
English: • severe uncontrolled hypertension
Slovenian: • resno nenadzorovano hipertenzijo
English: these medicines may increase the risk of side effects such as bleeding when given at the same time as Angiox.
Slovenian: Ta zdravila lahko povečajo tveganje za pojav neželenih učinkov, kot je krvavitev, če se jih daje skupaj z zdravilom Angiox.
English: In a clinical trial of 110 paediatric patients (neonates to <16 years of age) undergoing percutaneous intravascular procedures, the safety, pharmacokinetic and pharmacodynamic profile of bivalirudin was evaluated [TMC-BIV-07-01].
Slovenian: V kliničnem preskušanju s 110 pediatričnimi bolniki (novorojenčki do < 16 let starosti) z načrtovanimi perkutanimi intravaskularnimi postopki so ocenili varnost, farmakokinetiko in farmakodinamični profil bivalirudina [TMC-BIV-07-01].
English: The slide deck will contain the following key information:
Slovenian: Predstavitev z diapozitivi bo vsebovala spodnje ključne informacije:
English: The arterial sheath can be removed 2 hours after discontinuation of the bivalirudin infusion without anticoagulation monitoring.
Slovenian: Arterijsko iglo lahko odstranite dve uri po končani infuziji bivalirudina brez nadaljnjega nadzora antikoagulacije.
English: The most frequent event was a haematoma <5 cm at puncture site.
Slovenian: Najpogostejši neželeni učinek je bil hematom < 5 cm na mestu vboda.
English: • if you are having radiation treatment in the vessels that supply blood to the heart (treatment called beta or gamma brachytherapy).
Slovenian: • če se zdravite z obsevanjem žil, ki dostavljajo kri do srca (zdravljenje se imenuje beta ali gama brahiterapija)
English: WHAT ANGIOX IS AND WHAT IT IS USED FOR
Slovenian: Kaj je zdravilo Angiox in za kaj ga uporabljamo
English: Minor bleeding was defined as any observed bleeding event that did not meet the criteria as major.
Slovenian: Manjšo krvavitev so opredelili kot vsako opaženo krvavitev, ki ni izpolnjevala kriterijev za večjo krvavitev.
English: This dosing pattern was associated with increased in-hospital ischaemic events (MACE).
Slovenian: Ta vzorec odmerjanja je bil povezan z zvečanjem bolnišničnih ishemičnih dogodkov (MACE).
English: In clinical studies bivalirudin has been shown to provide adequate anticoagulation during PCI procedures.
Slovenian: Klinične študije kažejo, da bivalirudin omogoča zadostno antikoagulacijo med postopkom PCI.
English: Bivalirudin is rapidly distributed between plasma and extracellular fluid.
Slovenian: Bivalirudin se hitro porazdeli med plazmo in ekstracelularno tekočino.
English: The doctor will check the solution and will discard it, if it contains particles or is discoloured.
Slovenian: Zdravnik bo raztopino pregledal in jo zavrgel, če bo vsebovala delce ali če bo barva spremenjena..
English: The 30-day results based on quadruple and triple endpoints from a randomized, double-blind trial of over 6,000 patients undergoing PCI (REPLACE-2) are shown in Table 5.
Slovenian: 30-dnevni rezultati na osnovi štirikratnih in trikratnih opazovanih dogodkov, v randomiziranem, dvojno slepem preizkušanju s preko 6.000 bolniki med PCI (REPLACE-2) so prikazani v preglednici 5.
English: Bivalirudin remains active and is not neutralised by products of the platelet release reaction.
Slovenian: Bivalirudin ostane aktiven in ga ne nevtralizirajo produkti sprostitvene reakcije krvnih ploščic.
English: They may begin with limited symptoms such as itching, redness of the skin, rash or small bumps on the skin.
Slovenian: Lahko se začnejo z določenimi simptomi, kot so srbenje, rdečina kože, izpuščaj ali majhne bulice na koži.
English: Major bleeding in the HORIZONS study was also defined using the ACUITY scale.
Slovenian: Večja krvavitev v študiji HORIZON je bila prav tako opredeljena z uporabo lestvice ACUITY.
English: Clearance is reduced by approximately 20% in patients with moderate or severe renal impairment, and 80% in dialysis-dependent patients (Table 8).
Slovenian: Očistek se pri bolnikih z zmerno ali hudo ledvično okvaro zmanjša za približno 20 %, pri dializnih bolnikih pa za 80 % (preglednica 8).
English: OUTER CARTON (pack of 10 vials)
Slovenian: ŠKATLA (pakiranje z 10 vialami).
English: Do not administer intramuscularly.
Slovenian: Zdravila ne dajajte intramuskularno.
English: In the elderly, if their kidney function is decreased, the dose may need to be reduced.
Slovenian: Pri starejših ljudeh, ki imajo zmanjšano delovanje ledvic, bo morda treba odmerek zmanjšati.
English: As Angiox is a hospital only medicine, storage of Angiox is the responsibility of healthcare professionals.
Slovenian: Ker se zdravilo Angiox uporablja samo v bolnišnicah, je za shranjevanje zdravila Angiox odgovorno zdravstveno osebje.
English: Angiox contains a substance called bivalirudin which is an antithrombotic medicine.
Slovenian: Zdravilo Angiox vsebuje snov, ki se imenuje bivalirudin, in je antitrombotsko zdravilo.
English: Occasionally, reactions can be more severe with throat itching, throat tightening, swelling of the eyes, face, tongue or lips, high pitched whistling during inhaling (stridor), difficulty breathing or exhaling (wheezes).
Slovenian: Občasno so lahko reakcije hujše in vključujejo srbenje v grlu, stiskanje v grlu, otekanje oči, obraza, jezika in ustnic, visoki zvoki pri vdihavanju (stridor), oteženo dihanje ali izdihavanje (piskanje v pljučih).
English: It is unknown whether bivalirudin is excreted in human milk.
Slovenian: Ni jasno, ali se bivalirudin izloča v materino mleko.
English: A population pharmacokinetic/pharmacodynamic analysis, and an Exposure and Adverse Event Assessment Model based on the data from this study determined that in paediatric patients, use of the adult dosing with plasma levels similar to that achieved in adults was associated with lower levels of thrombotic events with no impact on bleeding events (see section 4.2).
Slovenian: Analiza farmakokinetike/farmakodinamike populacije in model izpostavljenosti in ocene neželenih dogodkov na podlagi podatkov te študije sta pokazala, da je bila pri pediatričnih bolnikih uporaba odmerka za odrasle z ravnmi v plazmi, podobnimi tistim, ki so bile dosežene pri odraslih, povezana z manjšo ravnjo trombotičnih dogodkov in ni imela vpliva na dogodke krvavitve (glejte poglavje 4.2).
English: Similar reductions in bleeding were observed in patients who were switched to bivalirudin from heparin-based therapies (N = 2,078).
Slovenian: Podobna znižanja števila primerov krvavitev je bilo opaziti tudi pri bolnikih, ki so prešli z zdravljenja na osnovi heparina na bivalirudin (N = 2.078).
English: In the event of major bleeding, treatment with bivalirudin should be immediately discontinued.
Slovenian: V primeru večje krvavitve nemudoma prekinite zdravljenje z bivalirudinom.
English: Angiox should be administered with acetylsalicylic acid and clopidogrel.
Slovenian: Zdravilo Angiox je treba dajati z acetilsalicilno kislino in klopidogrelom.
English: Angiox is not intended for intramuscular use.
Slovenian: Angiox ni namenjen intramuskularni uporabi.
English: Table 9 summarises compatible and incompatible concentrations of these compounds.
Slovenian: V preglednici 9 je prikazan povzetek združljivih in nezdružljivih koncentracij omenjenih učinkovin.
English: The primary analysis and results for ACUITY at 30-days and 1 year for the overall (ITT) population and for the patients that received acetylsalicylic acid and clopidogrel as per protocol (pre-angiography or pre-PCI) are shown in Tables 3 and 4.
Slovenian: Primarna analiza in rezultati študije ACUITY po 30 dneh in 1 letu za celotno vključeno populacijo (ITT) in za bolnike, ki so prejemali acetilsalicilno kislino ter klopidogrel v skladu s protokolom (pred angiografijo ali pred PCI), so prikazani v preglednicah 3 in 4.
English: In REPLACE-2, bleeding data were collected separately from adverse events.
Slovenian: V REPLACE-2 so bili podatki o krvavitvah zbrani ločeno od neželenih dogodkov.
English: o while you are in hospital: tell the doctor or nurseo after you've left hospital: first seek advice from your doctor.
Slovenian: o ko ste v bolnišnici: takoj obvestite zdravnika ali medicinsko sestro o ko zapustite bolnišnico: najprej poiščite nasvet svojega zdravnika.
English: Uncommonly (may affect up to 1 in 100 people) the number of blood platelets may be low which can worsen any bleeding.
Slovenian: Občasno (pojavijo se lahko pri največ 1 od 100 bolnikov) je lahko število krvnih ploščic majhno, kar lahko poslabša krvavitev.
English: To ensure appropriate administration of bivalirudin, the completely dissolved, reconstituted and diluted product should be thoroughly mixed prior to administration (see section 6.6).
Slovenian: Da bi zagotovili ustrezno dajanje bivalirudina, je potrebno pred dajanjem popolnoma raztopljeno, rekonstituirano in razredčeno zdravilo temeljito zmešati (glejte poglavje 6.6).
English: From the knowledge of their mechanism of action, combined use of anti-coagulant medicinal products (heparin, warfarin, thrombolytics or antiplatelet agents) can be expected to increase the risk of bleeding.
Slovenian: Ker poznamo njihov mehanizem delovanja, lahko pri skupni uporabi antikoagulantov (heparin, varfarin, trombolitiki ali zaviralci krvnih ploščic) pričakujemo povečano tveganje za krvavitve.
English: Patients with renal impairment should be carefully monitored for clinical signs of bleeding during PCI, as clearance of bivalirudin is reduced in these patients (see section 5.2)
Slovenian: Pri bolnikih z okvaro ledvic je treba skrbno spremljati klinične znake krvavitve med PCI, saj je očistek bivalirudina pri teh bolnikih zmanjšan (glejte poglavje 5.2).
English: Bleeding is more likely to occur when Angiox is used in combination with other anticoagulant or antithrombotic medicines (see section 2 ‘Taking other medicines').
Slovenian: Pojav krvavitve je bolj verjeten, kadar zdravilo Angiox uporabljate v kombinaciji z drugimi antikoagulacijskimi ali antitrombotičnimi zdravili (glejte poglavje 2 "Druga zdravila in zdravilo Angiox ").
English: In STEMI patients undergoing primary PCI, standard pre-hospital adjunctive therapy should include clopidogrel and may include the early administration of UFH (See section 5.1).
Slovenian: Pri bolnikih s STEMI, pri katerih se bo izvedla primarna PCI, mora standardna predhospitalizacijska terapija vključevati klopidogrel, lahko pa vključuje tudi zgodnjo uporabo UFH (glejte razdelek 5.1).