FrancophonIA/ELRC3.0 huggingface dataset:
English: Median overall survival Mean overall survival
Croatian: Medijan ukupnog preživljenja
English: The corresponding frequency category for each adverse drug reaction is based on the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000).
Croatian: Pripadajuće kategorije učestalosti za svaku nuspojavu temelje se na sljedećim kategorijama: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko
English: The degree of reduction is likely to be clinically significant (see sections 4.2, 4.5, 5.1 and 5.2).
Croatian: Stupanj navedenog smanjenja je vjerojatno klinički značajan (vidjeti dijelove 4.2, 4.5, 5.1 i 5.2).
English: A validated, robust, reliable and sensitive test with a prespecified positivity threshold and demonstrated utility for the determination of EGFR mutation status, using either tumor DNA derived from a tissue sample or circulating free DNA (cfDNA) obtained from a blood (plasma) sample, should be performed according to local medical practice.
Croatian: Potrebno je provesti validiran, robustan, pouzdan i osjetljiv test koji ima unaprijed određen prag za pozitivan rezultat i koji je dokazano koristan za utvrđivanje statusa EGFR mutacije, koristeći ili tumorsku DNK dobivenu iz uzorka tkiva ili cirkulirajuću slobodnu DNK (cfDNK) dobivenu iz uzorka krvi (plazme), u skladu s lokalnom medicinskom praksom.
English: Patients taking coumarin-derived anticoagulants should be monitored regularly for any changes in prothrombin time or INR.
Croatian: Bolesnike koji uzimaju kumarinske antikoagulanse je potrebno redovito pratiti i kontrolirati bilo kakve promjene u protrombinskom vremenu ili INR-u.
English: OS*** (months)
Croatian: OS*** (mjeseci)
English: Tarceva contains a sugar called lactose monohydrate.
Croatian: Tarceva sadrži šećer zvan laktoza hidrat.
English: Females
Croatian: Žene
English: Tarceva has not been studied for its possible effects on the ability to drive and use machines but it is very unlikely that your treatment will affect this ability.
Croatian: Nije ispitano moguće djelovanje lijeka Tarceva na sposobnost upravljanja motornim vozilima i strojevima, ali malo je vjerojatno da će liječenje utjecati na tu sposobnost.
English: ** Can lead to dehydration, hypokalemia and renal failure.
Croatian: ** Može prouzročiti dehidraciju, hipokalijemiju i zatajenje bubrega.
English: Erlotinib increases platinum concentrations.
Croatian: Erlotinib povećava koncentraciju platine.
English: Repeated twice daily doses of 200 mg in healthy subjects were poorly tolerated after only a few days of dosing.
Croatian: Zdrave osobe loše su podnijele ponovljenu dvostruku dnevnu dozu od 200 mg, i to nakon samo nekoliko dana doziranja.
English: In study BR.21, the median time to onset of rash was 8 days, and the median time to onset of diarrhoea was 12 days.
Croatian: U ispitivanju BR.21 pokazalo se da je medijan vremena do pojave osipa bilo 8 dana, a medijan vremena do pojave proljeva 12 dana.
English: First-Line Treatment of Patients with EGFR Mutations
Croatian: Prva linija liječenja bolesnika s mutacijama EGFR-a
English: Due to the blocking of downstream-signaling, the proliferation of cells is stopped, and cell death is induced through the intrinsic apoptotic pathway.
Croatian: Budući da je blokirana nizvodna signalizacija, zaustavlja se proliferacija stanica i inducira smrt stanice intrinzičkim apoptotskim putem.
English: Therefore, in such patients, periodic liver function testing should be considered.
Croatian: Stoga, u takvih bolesnika valja razmisliti o redovitim pretragama funkcije jetre.
English: There are no adequate data for the use of erlotinib in pregnant women.
Croatian: Nema dostatnih podataka o primjeni erlotiniba u trudnica.
English: The physiological relevance of the strong inhibition of CYP1A1 is unknown due to the very limited expression of CYP1A1 in human tissues.
Croatian: Fiziološka važnost jake inhibicije CYP1A1 nije poznata zbog vrlo ograničene ekspresije CYP1A1 u ljudskim tkivima.
English: This medicine can also be prescribed to you in combination with another treatment called gemcitabine if you have cancer of the pancreas at a metastatic stage.
Croatian: Ovaj Vam lijek također može biti propisan u kombinaciji s drugim lijekom pod nazivom gemcitabin ako imate rak gušterače u metastatskom stadiju.
English: In patients who do not develop rash within the first 4 - 8 weeks of treatment, further Tarceva treatment should be re-assessed (see section 5.1).
Croatian: U bolesnika u kojih se u prvih 4 do 8 tjedana liječenja ne pojavi osip, potrebno je razmotriti potrebu daljnjeg liječenja lijekom Tarceva (vidjeti dio 5.1).
English: The primary endpoint was survival.
Croatian: Primarni je ishod bio preživljenje.
English: Erlotinib and its metabolites are not significantly excreted by the kidney, as less than 9% of a single dose is excreted in the urine.
Croatian: Erlotinib i njegovi metaboliti ne izlučuju se u većim količinama putem bubrega, budući da se manje od 9% pojedinačne doze izlučuje u urinu.
English: If a plasma-based cfDNA test is used and the result is negative for activating mutations, perform a tissue test wherever possible due to the potential for false negative results from a plasma-based test.
Croatian: Ako se provodi test plazmatske cfDNK i dobije negativan nalaz na aktivirajuće mutacije, kad god je moguće treba provesti i test na uzorku tumorskog tkiva zbog mogućeg lažno negativnog nalaza testa na plazmatskom uzorku.
English: -Alopecia -Dry skin1
Croatian: - alopecija - suha koža 1
English: • if you are taking statins (medicines to lower your blood cholesterol), Tarceva may increase the risk of statin related muscle problems, which on rare occasions can lead to serious muscle breakdown (rhabdomyolysis) resulting in kidney damage, talk to your doctor.
Croatian: · ako uzimate statine (lijekove za sniženje razine kolesterola u krvi), Tarceva može povećati rizik nastanka problema s mišićima povezanih sa statinima, koji u rijetkim slučajevima mogu dovesti do ozbiljne razgradnje mišića (rabdomiolize) i posljedičnog oštećenja bubrega, obratite se svom liječniku.
English: Due to the working mechanism, proteasome inhibitors including bortezomib may be expected to influence the effect of EGFR inhibitors including erlotinib.
Croatian: Zbog njihovog mehanizma djelovanja može se očekivati utjecaj inhibitora proteasoma, uključujući bortezomib, na učinak EGFR inhibitora, uključujući erlotinib.
English: The first 330 patients were centrally assessed (response rate 6.2%); 401 patients were investigatorassessed (response rate 11.2%).
Croatian: U prvih 330 bolesnika procjenu stope odgovora provelo je neovisno centralno povjerenstvo (stopa odgovora od 6,2%), dok je u preostalih 401 bolesnika stopu odgovora ocijenio ispitivač (stopa odgovora od 11,2%).
English: The European Medicines Agency has waived the obligation to submit the results of studies with Tarceva in all subsets of the paediatric population in Non Small Cell Lung Cancer and Pancreatic cancer indications (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Tarceva u svim podskupinama pedijatrijske populacije u indikacijama rak pluća nemalih stanica i rak gušterače (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: However, an adverse effect on the pregnancy can not be excluded as rat and rabbit studies have shown increased embryo/foetal lethality (see section 5.3).
Croatian: Međutim, štetan učinak na trudnoću ne može biti isključen obzirom da su ispitivanja na štakorima i zečevima pokazala povećanu embrio/fetalnu smrtnost. (vidjeti dio 5.3).
English: Erlotinib has a mean apparent volume of distribution of 232 l and distributes into tumour tissue of humans.
Croatian: Erlotinib ima prosječan volumen raspodjele od 232 l i raspodjeljuje se u tumorsko tkivo ljudi.
English: Based on population pharmacokinetic analysis, no clinically significant relationship between predicted apparent clearance and patient age, bodyweight, gender and ethnicity were observed.
Croatian: Na temelju farmakokinetičke populacijske analize nije primijećen klinički značajan odnos između predviđenog prividnog klirensa i dobi bolesnika, tjelesne težine, spola i etničke pripadnosti.
English: Bullous, blistering and exfoliative skin conditions have been reported, including very rare cases suggestive of Stevens-Johnson syndrome/Toxic epidermal necrolysis, which in some cases were fatal (see section 4.8).
Croatian: Prijavljene su bulozne, eksfolijativne i vezikulozne promjene na koži, uključujući vrlo rijetke slučajeve koji upućuju na Stevens-Johnsonov sindrom/toksičnu epidermalnu nekrolizu, koje su u nekim slučajevima imale smrtni ishod (vidjeti dio 4.8).
English: In the remaining 55% of patients with unknown EGFR-expression status, the hazard ratio was 0.77 (95% CI 0.61-0.98).
Croatian: U preostalih 55% bolesnika s nepoznatim EGFR statusom ekspresije, omjer rizika bio je 0,77 (95% CI 0,61-0,98).
English: Therefore, concomitant administration of these combinations should be avoided (see section 4.5).
Croatian: Stoga treba izbjegavati istovremenu primjenu tih kombinacija (vidjeti dio 4.5).
English: The combination of Tarceva and a statin may increase the potential for statin-induced myopathy, including rhabdomyolysis, which was observed rarely.
Croatian: Kombinacija lijeka Tarceva i statina može povećati rizik od razvoja statinima uzrokovane miopatije, uključujući rabdomiolizu, što je rijetko opaženo.
English: Tablet coat: hypromellose, hydroxypropyl cellulose, titanium dioxide, macrogol.
Croatian: Ovojnica tablete: hipromeloza, hidroksipropilceluloza, titanijev dioksid, makrogol.
English: Data from reproductive toxicology tests in rats and rabbits at doses near the maximum tolerated dose and/or maternally toxic doses showed reproductive (embryotoxicity in rats, embryo resorption and foetotoxicity in rabbits) and developmental (decrease in pup growth and survival in rats) toxicity, but was not teratogenic and did not impair fertility.
Croatian: Podaci iz reproduktivnih toksikoloških ispitivanja na štakorima i zečevima u dozama blizu maksimalno podnošljive doze i/ili doza toksičnih za majku pokazali su reproduktivnu (embriotoksičnost u štakora, embrioresorpciju i fetotoksičnost u zečeva) i razvojnu (sporiji rast štenaca i preživljenje štakora) toksičnost, ali nisu se pokazali teratogenima niti su utjecali na plodnost.
English: -Hirsutism -Eyebrow changes -Brittle and Loose nails -Mild skin reactions such as hyperpigmen tation
Croatian: - hirzutizam - promjene na obrvama - lomljivi i labavi nokti - blaga reakcija kože poput hiperpigmentacije
English: A population pharmacokinetic analysis in 591 patients receiving single agent Tarceva shows a mean apparent clearance of 4.47 l/hour with a median half-life of 36.2 hours.
Croatian: Farmakokinetička populacijska analiza u 591 bolesnika koji su primali samo lijek Tarceva pokazuje prosječan prividni klirens od 4,47 l/sat s medijanom poluvijeka od 36,2 sata.
English: • if you are taking anticoagulants (a medicine which helps to prevent thrombosis or blood clotting e.g. warfarin), Tarceva may increase your tendency to bleed.
Croatian: · ako uzimate antikoagulanse (lijekove koji pomažu spriječiti nastanak tromboze ili krvnih ugrušaka poput varfarina) Tarceva može povećati sklonost krvarenju.
English: Patients treated concurrently with erlotinib and gemcitabine should be monitored carefully for the possibility to develop ILD-like toxicity.
Croatian: Bolesnike koji su istovremeno liječeni erlotinibom i gemcitabinom treba pažljivo nadzirati zbog mogućnosti razvoja toksičnosti nalik intersticijskoj bolesti pluća.
English: Although the Cmax was statistically significant lower in moderately hepatic impaired patients, this difference is not considered clinically relevant.
Croatian: Iako je Cmax statistički znatno niži u bolesnika s umjerenim oštećenjem jetre, ta se razlika ne smatra klinički značajnom.
English: Any Grade
Croatian: Bilo koji stupanj 3
English: Adequate contraceptive methods should be used during therapy, and for at least 2 weeks after completing therapy.
Croatian: Za vrijeme liječenja trebalo bi koristiti odgovarajuću kontracepciju, kao i najmanje 2 tjedna nakon završetka terapije.
English: Patients receiving Tarceva are at increased risk of developing gastrointestinal perforation, which was observed uncommonly (including some cases with a fatal outcome).
Croatian: Bolesnici koji primaju lijek Tarceva imaju povećani rizik razvoja gastrointestinalne perforacije, koja je zapažena kao manje česta (uključujući pojedine slučajeve sa smrtnim ishodom).
English: The tablet should be taken at least one hour before or two hours after the ingestion of food.
Croatian: Tabletu trebate uzeti barem jedan sat prije ili dva sata nakon obroka.
English: In population pharmacokinetic analysis, no clinically significant relationship was observed between erlotinib clearance and creatinine clearance, but there are no data available for patients with creatinine clearance <15 ml/min.
Croatian: U farmakokinetičkoj populacijskoj analizi nije uočena klinički značajna povezanost između klirensa erlotiniba i klirensa kreatinina, ali nisu dostupni podaci za bolesnike s klirensom kreatinina < 15 ml/min.
English: In non-clinical models, inhibition of EGFR phosphotyrosine results in cell stasis and/or death.
Croatian: U nekliničkim modelima inhibicija EGFR fosfotirozina dovodi do zastoja u rastu stanica i/ili smrti stanica.
English: The tablets contain lactose and should not be administered to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Croatian: Tablete Tarceva sadrže laktozu i ne smiju se davati bolesnicima s rijetkim nasljednim poremećajima nepodnošenja galaktoze, deficijencije Lapp laktaze ili malapsorpcije glukoze-galaktoze.
English: Such influence is supported by limited clinical data and preclinical studies showing EGFR degradation through the proteasome.
Croatian: Taj utjecaj podupiru ograničeni klinički podaci i pretklinička ispitivanja koji ukazuju na razgradnju EGFR djelovanjem proteasoma.
English: It is important to keep taking Tarceva every day, as long as your doctor prescribes it for you.
Croatian: Važno je lijek Tarceva uzimati svaki dan tijekom razdoblja koje Vam je propisao liječnik.
English: Tarceva with food and drink Do not take Tarceva with food.
Croatian: Tarceva s hranom i pićem
English: If you forget to take Tarceva
Croatian: Ako ste zaboravili uzeti lijek Tarceva
English: Rare side effects (may affect up to 1 in 1,000 people): • Flushed or painful palms or soles (Palmar plantar erythrodysaesthesia syndrome)
Croatian: Rijetke nuspojave (mogu se javiti kod manje od 1 na 1000 osoba): · crveni ili bolni dlanovi ili tabani (sindrom palmarno-plantarne eritrodizestezije)
English: Tarceva should be permanently discontinued in patients who develop gastrointestinal perforation (see section 4.8).
Croatian: Primjenu lijeka Tarceva bi trebalo trajno prekinuti u bolesnika koji razviju gastrointestinalnu perforaciju (vidjeti dio 4.8).
English: This analysis demonstrated that covariants affecting erlotinib clearance in patients from the pancreatic study were very similar to those seen in the prior single agent pharmacokinetic analysis.
Croatian: Ta je analiza pokazala da su kovarijante koje utječu na klirens erlotiniba u bolesnika s rakom gušterače veoma slične onima već viđenima u ranijoj analizi farmakokinetike monoterapije.
English: This medicine can be prescribed to you if you have non-small cell lung cancer at an advanced stage.
Croatian: Lijek Vam može biti propisan ako imate rak pluća nemalih stanica u uznapredovalom stadiju.
English: Eye irritation due to conjunctivitis/keratoconjunctivitis (very common: may affect more than 1 out of 10 people) and keratitis (common: may affect up to 1 in 10 people).
Croatian: Iritacija oka uslijed konjunktivitisa/keratokonjunktivitisa (vrlo često: može se javiti kod više od 1 na 10 osoba) i keratitis (često: može se javiti kod manje od 1 na 10 osoba).
English: Tarceva resulted in symptom benefits by significantly prolonging time to deterioration in cough, dyspnoea and pain, versus placebo.
Croatian: Primjena lijeka Tarceva rezultirala je poboljšanjem simptoma značajno produljujući vrijeme do pogoršanja kašlja, zaduhe i boli, u odnosu na placebo.
English: In more severe or persistent cases of diarrhoea, or cases leading to dehydration, particularly in groups of patients with aggravating risk factors (especially concomitant chemotherapy and other medications, symptoms or diseases or other predisposing conditions including advanced age), Tarceva therapy should be interrupted and appropriate measures should be taken to intensively rehydrate the patients intravenously.
Croatian: U težim ili dugotrajnim slučajevima proljeva ili stanjima koja dovode do dehidracije, osobito u skupinama bolesnika s dodatnim faktorima rizika (naročito istodobna primjena kemoterapije i drugih lijekova, simptomi ili bolesti ili druga predisponirajuća stanja, uključujući stariju dob) potrebno je prekinuti terapiju lijekom Tarceva i poduzeti odgovarajuće mjere za intenzivnu intravensku rehidraciju bolesnika.
English: There are three main metabolic pathways identified: 1) O-demethylation of either side chain or both, followed by oxidation to the carboxylic acids; 2) oxidation of the acetylene moiety followed by hydrolysis to the aryl carboxylic acid; and 3) aromatic hydroxylation of the phenyl-acetylene moiety.
Croatian: O-demetilacija jednog ili oba postranična lanca, nakon kojeg nastupa oksidacija karboksilnih kiselina, 2) oksidacija acetilenskog dijela, nakon koje slijedi hidroliza aril karboksilne kiseline i 3) aromatska hidroksilacija fenil-acetilenskog dijela.
English: Baseline ECOG performance status (PS) = 0 Baseline ECOG performance status (PS) = 1 Baseline ECOG performance status (PS) = 2 Metastatic disease at baseline
Croatian: Početni ECOG funkcionalni status (PS) = 0 Početni ECOG funkcionalni status (PS) = 1 Početni ECOG funkcionalni status (PS) = 2
English: Based on pharmacokinetic data no dose adjustments appear necessary in patients with mild or moderate renal impairment (see section 5.2).
Croatian: Na temelju farmakokinetičkih podataka čini se da nije potrebna prilagodba doze u bolesnika s blagim ili umjerenim oštećenjem bubrega (vidjeti dio 5.2).
English: Date of first authorization: 19 September 2005 Date of latest renewal: 2 July 2010
Croatian: Datum prvog odobrenja: 19. rujna 2005.
English: The recommended daily dose of Tarceva is 100 mg taken at least one hour before or two hours after the ingestion of food, in combination with gemcitabine (see the summary of product characteristics of gemcitabine for the pancreatic cancer indication).
Croatian: Preporučena dnevna doza lijeka Tarceva iznosi 100 mg i treba ju uzimati najmanje jedan sat prije ili dva sata nakon obroka, u kombinaciji s gemcitabinom (pogledajte sažetak opisa svojstava gemcitabina za indikaciju rak gušterače).
English: See sections 4.2, 4.4, 4.5 and 5.1.
Croatian: Vidjeti dijelove 4.2, 4.4, 4.5 i 5.1.
English: The potent effectiveness of erlotinib in blocking EGFR-mediated signalling in these EGFR mutation positive tumours is attributed to the tight binding of erlotinib to the ATP-binding site in the mutated kinase domain of the EGFR.
Croatian: Snažno blokirajuće djelovanje erlotiniba na EGFR-om posredovanu signalizaciju u tumorima pozitivnim na EGFR mutaciju pripisuje se snažnom vezanju erlotiniba na mjesto vezanja ATP-a u mutiranoj domeni EGFR kinaze.
English: In two other double-blind, randomised, placebo-controlled Phase III studies BO18192 (SATURN) and BO25460 (IUNO); Tarceva was administered as maintenance after first-line chemotherapy.
Croatian: U druga dva dvostruko slijepa, randomizirana, placebom kontrolirana ispitivanja faze III - BO18192 (SATURN) i BO25460 (IUNO) - Tarceva se primjenjivala kao terapija održavanja nakon prve linije kemoterapije.
English: Your doctor may adjust your dose in 50 mg steps.
Croatian: Liječnik će Vam možda prilagoditi dozu smanjivanjem doze za po 50 mg.
English: In a clinical study, the concomitant use of erlotinib with carboplatin and paclitaxel led to an increase of total platinum AUC0-48 of 10.6%.
Croatian: U kliničkom je ispitivanju istovremeno uzimanje erlotiniba uz karboplatin i paklitaksel prouzročilo povećanje ukupnog AUC0-48 platine od 10,6%.
English: • if you are taking other medicines that may increase or decrease the amount of erlotinib in your blood or influence its effect (for example antifungals like ketoconazole, protease inhibitors, erythromycin, clarithromycin, phenytoin, carbamazepine, barbiturates, rifampicin, ciprofloxacin, omeprazole, ranitidine, St. John's Wort or proteasome inhibitors), talk to your doctor.
Croatian: · ako uzimate druge lijekove koji mogu povećati ili smanjiti razinu erlotiniba u krvi ili utjecati na njegov učinak (kao što su lijekovi protiv gljivica poput ketokonazola, inhibitori proteaze, eritromicin, klaritromicin, fenitoin, karbamazepin, barbiturati, rifampicin, ciprofloksacin, omeprazol, ranitidin, gospina trava ili inhibitori proteasoma) obratite se svom liječniku.
English: For patients who are exposed to sun, protective clothing, and/or use of sunscreen (e.g. mineral-containing) may be advisable.
Croatian: Za bolesnike koji su izloženi suncu poželjna je zaštitna odjeća, i/ili upotreba sredstva za zaštitu od sunca (npr. koje sadrže minerale).
English: 4 In clinical studies, some cases have been associated with concomitant warfarin administration and some with concomitant NSAID administration (see section 4.5).
Croatian: 4 u kliničkim ispitivanjima neki slučajevi povezani su s istovremenom primjenom varfarina, a neki s istovremenom primjenom NSAIL-a (vidjeti dio 4.5).
English: Therefore, the time to reach steady state plasma concentration would be expected to occur in approximately 7-8 days.
Croatian: Prema tome, vrijeme dostizanja koncentracije stanja dinamičke ravnoteže u plazmi očekuje se u roku od 7 do
English: In the clinical studies doses were reduced by 50 mg steps.
Croatian: U kliničkim ispitivanjima doze su smanjene postupno za po 50 mg.
English: Similarly, the exposure to the active metabolite increased by about 60% and 48% for AUC and Cmax, respectively.
Croatian: Slično tome, raspoloživost aktivnog metabolita se povećala za oko 60% (AUC) i 48% (Cmax).
English: No studies on the effects on the ability to drive and use machines have been performed; however erlotinib is not associated with impairment of mental ability.
Croatian: Nisu provedena ispitivanja o utjecaju na sposobnost upravljanja motornim vozilima i rada sa strojevima, ali se erlotinib ne povezuje sa smanjenjem mentalnih sposobnosti.
English: This corresponded to an overall average of 63% (range 5-161%) of the steady state observed peak plasma concentrations.
Croatian: To je odgovaralo ukupnom prosjeku od 63% (u rasponu od 5 do 161%) opaženih vršnih koncentracija u plazmi u stanju dinamičke ravnoteže.
English: Based on the data from the BO25460 (IUNO) study, Tarceva use is not recommended for first-line maintenance treatment in patients without an EGFR activating mutation.
Croatian: Temeljem podataka iz ispitivanja BO25460 (IUNO), ne preporučuje se primjena lijeka Tarceva za prvu liniju terapije održavanja u bolesnika bez aktivirajuće mutacije EGFR-a.
English: Pharmacotherapeutic group: antineoplastic agent protein kinase inhibitor, ATC code: L01XE03
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: antineoplastični lijekovi; inhibitor protein kinaze, ATK oznaka: L01XE03
English: Pre-treatment or co-administration of Tarceva did not alter the clearance of the prototypical CYP3A4 substrates, midazolam and erythromycin, but did appear to decrease the oral bioavailability of midazolam by up to 24%.
Croatian: Prethodno ili istovremeno uzimanje lijeka Tarceva nije utjecalo na klirens prototipnih supstrata CYP3A4, midazolama i eritromicina, ali čini se da je smanjilo peroralnu bioraspoloživost midazolama za do 24%.