FrancophonIA/ELRC3.0 huggingface dataset:
English: The recommended dose of efavirenz in combination with a PI and/or NRTIs for patients between 3 months and 17 years of age is described in Table 1.
Croatian: Preporučene doze efavirenza u kombinaciji s inhibitorom proteaze i/ili NRTI-ma za bolesnike u dobi između 3 mjeseca i 17 godina prikazane su u Tablici 1.
English: In in vitro studies efavirenz did not inhibit CYP2E1 and inhibited CYP2D6 and CYP1A2 only at concentrations well above those achieved clinically.
Croatian: U istraživanjima in vitro efavirenz nije inhibirao CYP2E1, a CYP2D6 i CYP1A2 je inhibirao samo pri koncentracijama koje su bile znatno više od kliničkih.
English: Patients should be informed that if they do occur, these common symptoms are likely to improve with continued therapy and are not predictive of subsequent onset of any of the less frequent psychiatric symptoms.
Croatian: Ako se ovi česti simptomi pojave, bolesnike se mora informirati da će se njihovo stanje vjerojatno poboljšati s nastavkom liječenja i da njihova pojava nije predznak kasnijeg nastupa nekih manje čestih psihijatrijskih simptoma.
English: Add another small amount (approximately 2 teaspoons) of the food to the empty mixing container, stirring to make sure there is no drug residue remaining in the container, and have the child eat the full amount again.
Croatian: Kako bi se pokupili ikakvi ostaci lijeka u posudi, dodajte malu količinu hrane (oko 2 čajne žličice) u praznu posudu, pomiješajte kako bi se uvjerili da nema ostataka lijeka u posudi te dajte djetetu da ponovo pojede sav sadržaj.
English: Mean Cmax µg/mL
Croatian: Srednja vrijednost Cmax µg/ml
English: Concomitant administration with efavirenz should be avoided due to the risk for QTc prolongation (see section 4.3).
Croatian: Potrebno je izbjegavati istodobnu primjenu s efavirenzom zbog rizika od pojave produljenja QTc intervala (vidjeti dio 4.3).
English: Implant: Etonogestrel/Efavirenz Decreased exposure of etonogestrel may be expected (CYP3A4 induction).
Croatian: implantat: etonogestrel/efavirenz Može se očekivati smanjena izloženost etonogestrelu (indukcija CYP3A4).
English: A multipledose study showed no significant effect on efavirenz pharmacokinetics in patients with mild hepatic impairment (Child-Pugh Class A) compared with controls.
Croatian: Ispitivanje s višekratnim dozama nije pokazalo značajan učinak na farmakokinetiku efavirenza u bolesnika s blagim oštećenjem jetre (Child-Pugh stadij A) u odnosu na kontrolnu skupinu.
English: Reported rates of recurrent rash following a switch from nevirapine to efavirenz therapy, primarily based on retrospective cohort data from published literature, range from 13 to 18%, comparable to the rate observed in patients treated with efavirenz in clinical studies.
Croatian: Prijavljene stope rekurentnog osipa nakon prelaska s liječenja nevirapinom na liječenje efavirenzom, prvenstveno na temelju podataka iz retrospektivnih kohortnih ispitivanja iz objavljene literature, kreću se od 13 do 18%, što je usporedivo sa stopama opaženim u bolesnika liječenih efavirenzom u kliničkim ispitivanjima (vidjeti dio 4.4).
English: Based on the concentration-QTc relationship, the mean QTc prolongation and its upper bound 90% confidence interval are 8.7 ms and 11.3 ms in subjects with CYP2B6*6/*6 genotype following the administration of 600 mg daily dose for 14 days (see section 4.5).
Croatian: Na temelju odnosa koncentracije i QTc intervala, srednja vrijednost produljenja QTc intervala i gornja granica raspona pouzdanosti od 90% iznose 8,7 ms i 11,3 ms u ispitanika s genotipom CYP2B6*6/*6 nakon primjene dnevne doze od 600 mg tijekom 14 dana (vidjeti dio 4.5).
English: No dose adjustment is necessary for raltegravir.
Croatian: Nije potrebno prilagođavati dozu raltegravira.
English: These problems tend to occur more often in those who have a history of mental illness.
Croatian: Ovakve nuspojave češće se javljaju u bolesnika koji su bolovali od neke psihičke bolesti.
English: The recommended dose of efavirenz in combination with nucleoside analogue reverse transcriptase inhibitors (NRTIs) with or without a PI (see section 4.5) is 600 mg orally, once daily.
Croatian: Preporučena doza lijeka efavirenz u kombinaciji s nukleozidnim analozima inhibitora reverzne transkriptaze (engl. nucleoside analogue reverse transcriptase inhibitors, NRTI), s inhibitorom proteaze ili bez njega (vidjeti dio 4.5), jest 600 mg peroralno, jedanput na dan.
English: uncommon affect lability, aggression, confusional state, euphoric mood, hallucination, mania, paranoia, psychosis†, suicide attempt, suicide ideation, catatonia*
Croatian: manje često emocionalna labilnost, agresija, stanje konfuzije, euforično raspoloženje, halucinacije, manija, paranoja, psihoza†, pokušaj samoubojstva, suicidalne misli, katatonija*
English: The potential for cross-resistance between efavirenz and NRTIs is low because of the different binding sites on the target and mechanism of action.
Croatian: Vjerojatnost križne rezistencije između efavirenza i NRTI-ja je mala jer imaju različita vezna mjesta i različite mehanizme djelovanja.
English: c S.E.M., standard error of the mean.
Croatian: c S.E.M., standardna pogreška srednje vrijednosti.
English: QTc Prolongation
Croatian: Produljenje QTc intervala
English: Concomitant administration of efavirenz with elbasvir/grazoprevir is contraindicated because it may lead to loss of virologic response to elbasvir/grazoprevir.
Croatian: Istodobna primjena efavirenza s elbasvirom/grazoprevirom je kontraindicirana jer može uzrokovati gubitak virološkog odgovora na elbasvir/grazoprevir.
English: There were insufficient data to determine whether moderate or severe hepatic impairment (Child-Pugh Class B or C) affects efavirenz pharmacokinetics.
Croatian: Nije bilo dovoljno podataka da bi se moglo odrediti utječe li umjereno ili teško oštećenje jetre (Child Pugh stadij B ili C) na farmakokinetiku efavirenza.
English: It is recommended to hold the capsule with the cap facing up and to pull the cap away from the body of the capsule, and to mix the capsule contents with food in a small container.
Croatian: Preporuka je da se kapsula drži u položaju s kapicom okrenutom prema gore te da se kapica povlačenjem odvoji od kapsule i potom da se sadržaj kapsule promiješa s hranom u maloj posudi.
English: The effect of efavirenz on male and female fertility in rats has only been evaluated at doses that achieved systemic drug exposures equivalent to or below those achieved in humans given recommended doses of efavirenz.
Croatian: Učinak efavirenza na plodnost mužjaka i ženki štakora ispitivan je samo pri dozama kojima se postiže sistemska izloženost lijeku jednaka ili manja od sistemske izloženosti u ljudi koji su primali preporučene doze efavirenza.
English: Dose adjustments of calcium channel blockers should be guided by clinical response (refer to the Summary of Product Characteristics for the calcium channel blocker).
Croatian: Pri prilagodbi doze blokatora kalcijevih kanala treba se voditi kliničkim odgovorom (vidjeti Sažetak opisa svojstava lijeka za blokator kalcijevih kanala).
English: Bupropion (a medicine used to treat depression or to help you stop smoking): your doctor may need to change your dose of bupropion.
Croatian: bupropion (lijek koji se koristi za liječenje depresije ili za pomoć pri prestanku pušenja): liječnik će Vam možda trebati promijeniti dozu bupropiona.
English: Contraindications of concomitant use
Croatian: Kontraindikacije za istodobnu primjenu
English: Mean Cmin µg/mL
Croatian: Srednja vrijednost Cmin µg/ml
English: They include some common medicines and a herbal remedy (St. John's wort) which can cause serious interactions.
Croatian: Obuhvaćaju neke lijekove koji se često uzimaju i biljni pripravak (gospinu travu) koji mogu izazvati ozbiljne interakcije.
English: Responder rates were highest in patients who switched NRTIs.
Croatian: Stope bolesnika koji su odgovorili na liječenje bile su najveće među bolesnicima koji su promijenili NRTI.
English: Liver enzymes in hepatitis B or C co-infected patients: in the long-term data set from study 006, 137 patients treated with efavirenz-containing regimens (median duration of therapy, 68 weeks) and 84 treated with a control regimen (median duration, 56 weeks) were seropositive at screening for hepatitis B (surface antigen positive) and/or C (hepatitis C antibody positive).
Croatian: Jetreni enzimi u bolesnika istodobno zaraženih virusom hepatitisa B ili C: prema podacima dugoročnog ispitivanja iz ispitivanja 006, 137 bolesnika na režimu koji je uključivao efavirenz (medijan trajanja terapije 68 tjedana) i 84 bolesnika na kontrolnom režimu (medijan trajanja 56 tjedana) bilo je seropozitivno na probiru na hepatitis B (pozitivan površinski antigen) i/ili hepatitis C (pozitivno protutijelo na hepatitis C).
English: If you have severe liver disease, do not take SUSTIVA (see section 2, Do not take SUSTIVA).
Croatian: Ako imate tešku bolest jetre, nemojte uzimati lijek SUSTIVA (pogledajte dio 2.
English: If you notice any of these symptoms please inform your doctor.
Croatian: Ako opazite neki od tih simptoma, molimo obavijestite svog liječnika.
English: Because of the extensive cytochrome P450-mediated metabolism of efavirenz and limited clinical experience in patients with chronic liver disease, caution must be exercised in administering efavirenz to patients with mild hepatic impairment.
Croatian: Budući da se efavirenz značajno metabolizira posredstvom citokroma P450 te zbog ograničenog kliničkog iskustva u bolesnika s kroničnom bolešću jetre, potreban je oprez pri primjeni efavirenza u bolesnika s blagim oštećenjem funkcije jetre.
English: In a subset of 1,008 adult patients who received 600 mg efavirenz daily in combination with PIs and/or NRTIs in controlled clinical studies, the most frequently reported adverse reactions of at least moderate severity reported in at least 5% of patients were rash (11.6%), dizziness (8.5%), nausea (8.0%), headache (5.7%) and fatigue (5.5%).
Croatian: U podskupini od 1008 odraslih bolesnika koji su u kontroliranim kliničkim ispitivanjima primali efavirenz u dozi od 600 mg na dan u kombinaciji s inhibitorima proteaze i/ili NRTI-ma najčešće prijavljene nuspojave koje su bile najmanje umjereno teške i prijavljene u najmanje 5% bolesnika bile su: osip (11,6%), omaglica (8,5%), mučnina (8,0%), glavobolja (5,7%) i umor (5,5%).
English: Dark yellow and white, printed with "SUSTIVA" on the dark yellow cap and "50 mg" on the white body.
Croatian: Tamnožuto-bijele, s otisnutom oznakom „SUSTIVA“ na tamnožutoj kapici i „50 mg“ na bijelom tijelu.
English: PHARMACEUTICAL FORM AND CONTENTS Multipack: 90 (3 packs of 30 x 1) film-coated tablets
Croatian: 4. FARMACEUTSKI OBLIK I SADRŽAJ Višestruko pakiranje: 90 (3 pakiranja od 30 x 1) filmom obloženih tableta
English: *lower than recommended doses; similar findings are expected with recommended doses.
Croatian: * niža doza od preporučene, očekuju se isti nalazi i kod preporučene doze darunavir:
English: Clinically significant interactions are not expected since vigabatrin and gabapentin are exclusively eliminated unchanged in the urine and are unlikely to compete for the same metabolic enzymes and elimination pathways as efavirenz.
Croatian: Klinički značajne interakcije se ne očekuju jer se vigabatrin i gabapentin izlučuju isključivo nepromijenjeni mokraćom i nije vjerojatno da će se natjecati za iste metaboličke enzime i putove eliminacije s efavirenzom.
English: There have been seven retrospective reports of findings consistent with neural tube defects, including meningomyelocele, all in mothers exposed to efavirenz-containing regimens (excluding any efavirenzcontaining fixed-dose combination tablets) in the first trimester.
Croatian: Postoji sedam retrospektivnih izvješća s nalazima koji upućuju na oštećenja neuralne cijevi, uključujući meningomijelokelu, u djece čije su majke u prvom tromjesečju trudnoće bile izložene režimu liječenja efavirenzom (ne uključuje tablete s fiksnom kombinacijom koje sadrže efavirenz).
English: SUSTIVA, which contains the active substance efavirenz, belongs to a class of antiretroviral medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Croatian: SUSTIVA, koja sadrži djelatnu tvar efavirenz, pripada skupini antiretrovirusnih lijekova koji se nazivaju nenukleozidni inhibitori reverzne transkriptaze (NNRTI).
English: Immunosuppressants such as cyclosporine, sirolimus, or tacrolimus (medicines used to prevent organ transplant rejection): when you start or stop taking SUSTIVA, your doctor will closely monitor your plasma levels of the immunosuppressant and may need to adjust its dose.
Croatian: imunosupresive kao što su ciklosporin, sirolimus ili takrolimus (lijekovi koji se koriste za sprečavanje odbacivanja presađenog organa): kada počnete ili prestanete lijek SUSTIVA, liječnik će Vam pažljivo nadzirati koncentraciju imunosupresiva u plazmi i možda će morati prilagođavati njihovu dozu.
English: Medicines used to lower blood fats (also called statins): atorvastatin, pravastatin, simvastatin.
Croatian: lijekove koji se koriste za snižavanje masnoća u krvi (zovu se i statini): atorvastatin, pravastatin, simvastatin.
English: When treatment with voriconazole is stopped, the initial dose of efavirenz should be restored.
Croatian: Kada liječenje vorikonazolom završi, mora se ponovno dati početna doza efavirenza.
English: Packs of 42 x 1 hard capsules in aluminium/PVC perforated unit dose blisters.
Croatian: Pakiranja s 42 x 1 tvrdom kapsulom u aluminij/PVC perforiranim blisterima djeljivima na jedinične doze.
English: SUSTIVA can reduce or increase the amount of anticonvulsant in your blood.
Croatian: SUSTIVA može smanjiti ili povećati koncentraciju antikonvulziva u krvi.
English: It is used by adults, adolescents and children 3 months of age and older and weighing at least 3.5 kg.
Croatian: Uzimaju ga odrasli, adolescenti i djeca u dobi od 3 mjeseca i starija, tjelesne težine od najmanje 3,5 kg.
English: Neither aluminium/magnesium hydroxide antacids nor famotidine altered the absorption of efavirenz.
Croatian: Antacidi koji sadrže aluminijev/magnezijev hidroksid kao ni famotidin nisu mijenjali apsorpciju efavirenza.
English: One hundred two patients 3 months to 16 years of age (median 5.7 years) were treated with SUSTIVA.
Croatian: Stotinu i dva bolesnika u dobi od 3 mjeseca do 16 godina (medijan 5,7 godina) liječeni su lijekom SUSTIVA.
English: In clinical studies, 26% of patients treated with 600 mg of efavirenz experienced skin rash compared with 17% of patients treated in control groups.
Croatian: U kliničkim je ispitivanjima 26% bolesnika liječenih efavirenzom u dozi od 600 mg imalo kožni osip, u odnosu na 17% onih u kontrolnim skupinama.
English: In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Croatian: Osim oportunističkih infekcija, nakon što počnete uzimati lijekove za liječenje HIV infekcije mogu nastupiti i autoimuni poremećaji (stanje koje se javlja kada imunološki sustav napada zdravo tkivo u tijelu).
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: U pacijenata inficiranih HIV-om s teškom imunodeficijencijom u vrijeme početka kombinirane antiretrovirusne terapije (CART) može nastati upalna reakcija na asimptomatske ili rezidualne oportunističke infekcije.
English: Efavirenz in combination with darunavir/ritonavir 800/100 mg once daily may result in suboptimal darunavir Cmin.
Croatian: Primjena efavirenza u kombinaciji s darunavirom/ritonavirom u dozi od 800/100 mg jedanput na dan može rezultirati suboptimalnim Cmin darunavira.
English: Each carton contains 1 bottle of 30 hard capsules.
Croatian: Jedna kutija sadrži 1 bočicu s 30 tvrdih kapsula.
English: Barrier contraception should always be used in combination with other methods of contraception (for example, oral or other hormonal contraceptives, see section 4.5).
Croatian: Uvijek treba primjenjivati mehanička kontracepcijska sredstva u kombinaciji s drugim metodama kontracepcije (kao što su oralni i drugi hormonski kontraceptivi, vidjeti dio 4.5).
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Croatian: Bolesnike se mora uputiti da potraže liječničku pomoć osjete li tupu bol i probadanja u zglobovima, ukočenost zglobova ili imaju poteškoća pri pokretima.
English: Other macrolide antibiotics (e.g.,erythromycin)/Efavirenz
Croatian: drugi makrolidni antibiotici (npr. eritromicin)/efavirenz
English: Efavirenz is an in vivo inducer of CYP3A4, CYP2B6 and UGT1A1.
Croatian: Efavirenz je in vivo induktor CYP3A4, CYP2B6 i UGT1A1.
English: Clinically significant interactions are not expected since the NRTIs are metabolised via a different route than efavirenz and would be unlikely to compete for the same metabolic enzymes and elimination pathways.
Croatian: Ne očekuju se klinički značajne interakcije jer se NRTI ne metaboliziraju istim putem kao efavirenz pa nije vjerojatno da bi došlo do kompeticije za iste metaboličke enzime i putove eliminacije.
English: Sufficient data on the tolerability of efavirenz with lowdose ritonavir (100 mg, once or twice daily) are not available.
Croatian: Nije dostupno dovoljno podataka o podnošljivosti efavirenza s niskom dozom ritonavira (100 mg jedanput ili dvaput na dan).
English: Protease inhibitor : Elbasvir/ grazoprevir
Croatian: Inhibitor proteaze: elbasvir/grazoprevir
English: Hepatobiliary disorders common aspartate aminotransferase (AST) increased*, alanine aminotransferase (ALT) increased*, gamma-glutamyltransferase (GGT) increased*
Croatian: Poremećaji jetre i žuči često povišene vrijednosti aspartat aminotransferaze (AST)*, povišene vrijednosti alanin aminotransferaze (ALT)*, povišene vrijednosti gama-glutamiltransferaze (GGT)*
English: d S.E.M., standard error of the mean.
Croatian: d S.E.M., standardna pogreška srednje vrijednosti.
English: Your doctor may consider giving you an alternative medicine or changing the dose of the protease inhibitors.
Croatian: Liječnik može razmotriti mogućnost uvođenja nekog drugog lijeka ili promijeniti dozu inhibitora proteaze.
English: Forty-three patients 3 months to 21 years of age (median 9.6 years) were dosed with SUSTIVA.
Croatian: Četrdeset tri bolesnika u dobi od 3 mjeseca do 21 godinu (medijan 9,6 godina) primali su lijek SUSTIVA.
English: Medicines used to treat convulsions/seizures (anticonvulsants): carbamazepine, phenytoin, phenobarbital.
Croatian: lijekove koji se koriste za liječenje konvulzija/napadaja (antikonvulzive): karbamazepin, fenitoin, fenobarbital.
English: If you have any further questions, ask your doctor, pharmacist or nurse.
Croatian: Ako imate dodatnih pitanja, obratite se liječniku, ljekarniku ili medicinskoj sestri.
English: Buprenorphine/naloxone/Efavirenz Buprenorphine: AUC: ↓ 50%
Croatian: buprenorfin/nalokson/efavirenz buprenorfin: AUC: ↓ 50% norbuprenorfin:
English: When efavirenz is coadministered with an anticonvulsant that is a substrate of CYP450 isoenzymes, periodic monitoring of anticonvulsant levels should be conducted.
Croatian: Kad se efavirenz primjenjuje istodobno s antikonvulzivom koji je supstrat izoenzima CYP450 mora se periodički kontrolirati koncentracija antikonvulziva.
English: For monitoring of blood lipids and glucose reference is made to established HIV treatment guidelines.
Croatian: Za nadzor lipida u krvi date su preporuke u utvrđenim smjernicama za liječenje HIV-a.
English: False-positive urine cannabinoid test results have been reported with some screening assays in uninfected and HIV-infected subjects receiving efavirenz.
Croatian: Kod primjene nekih probirnih testova prijavljeni su lažno pozitivni rezultati na kanabinoide u mokraći u nezaraženih ispitanika i ispitanika zaraženih HIV-om koji su primali efavirenz.
English: The clinical implications of such an association are unknown; however, the potential for an increased frequency and severity of efavirenz-associated adverse events cannot be excluded.
Croatian: Klinički značaj ove povezanosti nije poznat; međutim, ne može se isključiti mogućnost učestalijih i težih nuspojava povezanih s primjenom efavirenza.
English: No dose recommendation can be made.
Croatian: Ne može se dati preporuka za dozu.
English: One child was reported to have a neural tube defect, and the frequency and pattern of other birth defects were similar to those seen in children exposed to non-efavirenz-containing regimens, as well as those in HIV negative controls.
Croatian: U jednog djeteta je prijavljeno oštećenje neuralne cijevi, dok su učestalost i obrazac pojavljivanja drugih kongenitalnih malformacija bili slični onima opaženim u djece čije su majke bile izložene režimima liječenja bez efavirenza te onima u kontrolnoj skupini HIV negativnih trudnica.
English: Glecaprevir/pibrentasvir
Croatian: glekaprevir/pibrentasvir
English: common pruritus uncommon erythema multiforme, Stevens-Johnson syndrome*
Croatian: često pruritus manje često multiformni eritem, Stevens-Johnsonov sindrom*
English: The pattern of amino acid substitutions in RT associated with resistance to efavirenz was independent of the other antiviral medicines used in combination with efavirenz.
Croatian: Na obrazac zamjena aminokiselina u reverznoj transkriptazi udruženih s rezistencijom na efavirenz nije utjecao drugi antivirusni lijek koji se primjenjivao u kombinaciji s efavirenzom.
English: PARTICULARS TO APPEAR ON OUTER PACKAGING CARTON TEXT FOR BLISTER INTERMEDIATE PACK, COMPONENT OF A MULTIPACK (WITHOUT BLUE BOX)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU TEKST NA UNUTARNJOJ KUTIJI S BLISTERIMA, SASTAVNI DIO VIŠESTRUKOG PAKIRANJA (BEZ PLAVOG OKVIRA)
English: Study ACTG 364 enrolled 196 patients who had been treated with NRTIs but not with PIs or NNRTIs.
Croatian: U ispitivanje ACTG 364 uključeno je 196 bolesnika koji su već primali NRTI-je, ali ne i inhibitore proteaze ili NNRTI-je.
English: Consider alternatives to efavirenz for coadministration with a drug with a known risk of Torsade de Pointes or when to be administered to patients at higher risk of Torsade de Pointes.
Croatian: Razmotrite primjenu alternativne terapije umjesto istodobne primjene efavirenza s lijekom za koji je poznato da postoji rizik od torsade de pointes ili u bolesnika s povećanim rizikom od torsade de pointes.
English: The in vitro studies suggest that CYP3A4 and CYP2B6 are the major isozymes responsible for efavirenz metabolism and that it inhibited P450 isozymes 2C9, 2C19, and 3A4.
Croatian: Istraživanja in vitro pokazuju da su CYP3A4 i CYP2B6 glavni izoenzimi uključeni u metabolizam efavirenza te da efavirenz inhibira izoenzime citokroma P450 2C9, 2C19 i 3A4.
English: The choice of new antiretroviral agent(s) to be used in combination with efavirenz should take into consideration the potential for viral cross-resistance (see section 5.1).
Croatian: Pri izboru novih antiretrovirusnih lijekova za kombiniranu primjenu s efavirenzom mora se razmotriti mogućnost razvoja virusne križne rezistencije (vidjeti dio 5.1).
English: Experience with efavirenz in patients who discontinued other antiretroviral agents of the NNRTI class is limited (see section 4.8).
Croatian: Iskustvo s primjenom efavirenza u bolesnika koji su prekinuli liječenje drugim antiretrovirusnim lijekovima iz skupine NNRTI-ja je ograničeno (vidjeti dio 4.8).
English: This may make some side effects (for example, dizziness, drowsiness) less troublesome.
Croatian: To može ublažiti neke nuspojave (npr. omaglicu, omamljenost).