FrancophonIA/ELRC3.0 huggingface dataset:
English: Gynaecological haemorrhage Menstrual disorder Sexual dysfunction Testicular pain
Slovenian: Motnje reprodukcije in dojk erektilna disfunkcija motnje ejakulacije zapoznela ginekološka krvavitev motnje menstruacije spolna menopavzalni simptomi galaktoreja hiperprolaktinemija ejakulacija disfunkcija bolečina v testisih poporodna krvavitev6
English: Xeristar 60 mg hard gastro-resistant capsules Duloxetine
Slovenian: Xeristar 60 mg trde gastrorezistentne kapsule duloksetin
English: Xeristar 30 mg hard gastro-resistant capsules Duloxetine
Slovenian: Xeristar 30 mg trde gastrorezistentne kapsule duloksetin
English: − have liver disease
Slovenian: Bolezni sečil
English: What you need to know before you take Xeristar DO NOT take Xeristar if you:
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Xeristar
English: - If you get any of the side effects talk to your doctor or pharmacist.
Slovenian: - Če opazite katerikoli neželeni učinek, se posvetujte s svojim zdravnikom ali s farmacevtom.
English: Call your doctor or pharmacist immediately if you take more than the amount of Xeristar prescribed by your doctor.
Slovenian: Če vzamete večjo količino zdravila Xeristar, kot vam je predpisal vaš zdravnik, nemudoma pokličite svojega zdravnika ali farmacevta.
English: Xeristar is a hard gastro-resistant capsule.
Slovenian: FARMACEVTSKA OBLIKA trde gastrorezistentne kapsule
English: − are taking other medicines containing duloxetine (see ‘Other medicines and Xeristar') Talk to your doctor if you have high blood pressure or heart disease.
Slovenian: - jemljete druga zdravila, ki vsebujejo duloksetin (glejte »Druga zdravila in zdravilo Xeristar«)
English: Check with your doctor if you are already taking other medicines containing duloxetine.
Slovenian: Če že jemljete druga zdravila, ki vsebujejo duloksetin, se o tem pogovorite s svojim zdravnikom.
English: Xeristar is for oral use.
Slovenian: Zdravilo Xeristar jemljemo peroralno.
English: Xeristar contains sucrose.
Slovenian: Zdravilo Xeristar vsebuje saharozo.
English: Suicide-related behaviours (suicide attempts and suicidal thoughts), and hostility (predominantly aggression, oppositional behaviour and anger), were more frequently observed in clinical trials among children and adolescents treated with antidepressants compared to those treated with placebo.
Slovenian: ki so prejemali placebo, so pogosteje opažali s samomorom povezana vedenja (poskusi samomora in samomorilne misli) in sovražnost (zlasti nasilnost, nasprotovalno vedenje in jezo).
English: • night sweats, hives, cold sweats, sensitivity to sunlight, increased tendency to bruise
Slovenian: • vnetje jeter, ki lahko povzroči bolečine v trebuhu in rumeno obarvanje kože ali beločnice • nočno potenje, koprivnica, hladen znoj, občutljivost na sončno svetlobo, povečano nagnjenje k modricam
English: Sodium lauryl sulfate Titanium dioxide (E171) Indigo carmine (E132) Edible green ink
Slovenian: Xeristar 30 mg želatina natrijev lavrilsulfat titanov dioksid (E171) indigotin (E132)
English: • large pupils (the dark centre of the eye), problems with eyesight
Slovenian: • večje zenice (temni osrednji del očesa), motnja vida • omotica ali vrtoglavica (vertiga), ušesna bolečina
English: Contains sucrose See leaflet for further information
Slovenian: Shranjevanje zdravila Xeristar Vsebina pakiranja in dodatne informacije
English: Monoamine oxidase inhibitors (MAOIs): You should not take Xeristar if you are taking, or have recently taken (within the last 14 days) another antidepressant medicine called a monoamine oxidase inhibitor (MAOI).
Slovenian: NE jemljite zdravila Xeristar, če: - ste alergični (preobčutljivi) na duloksetin ali katerokoli drugo sestavino tega zdravila (navedeno v poglavju 6) - imate obolenje jeter - imate hudo obolenje ledvic - jemljete ali ste v zadnjih 14 dneh jemali drugo antidepresivno zdravilo, imenovano zaviralec monoaminooksidaze (MAOI) (glejte »Druga zdravila in zdravilo Xeristar«)
English: − are taking or have taken within the last 14 days, another medicine known as a monoamine oxidase inhibitor (MAOI) (see ‘Other medicines and Xeristar')
Slovenian: 14 dneh vzeli drugo antidepresivno zdravilo, imenovano zaviralec monoaminooksidaze (MAOI).
English: • feeling of dizziness or “spinning” (vertigo), ear pain
Slovenian: • občutek slabosti (navzea), suha usta
English: Xeristar 30 mg hard gastro-resistant capsules.
Slovenian: 30 mg trde gastrorezistentne kapsule
English: Metabolism and nutrition disorders Decreased
Slovenian: Presnovne in prehranske motnje zmanjšanje apetita hiperglikemija
English: Xeristar 60 mg hard gastro-resistant capsules.
Slovenian: 60 mg trde gastrorezistentne kapsule
English: Eli Lilly Italia S.p.A. Tel: + 39- 055 42571
Slovenian: Quintiles Commercial Italia srl Tel: + 39-02-957941
English: Constipation Diarrhoea Abdominal pain Vomiting Dyspepsia Flatulence
Slovenian: Bolezni živčevja glavobol zaspanost omotica letargija tremor parestezija
English: Caution is advised if Xeristar is co-administered with medicinal products that are predominantly metabolised by CYP2D6 (risperidone, tricyclic antidepressants [TCAs] such as nortriptyline, amitriptyline, and imipramine) particularly if they have a narrow therapeutic index (such as flecainide, propafenone and metoprolol).
Slovenian: (risperidon, triciklični antidepresivi [tricyclic antidepressants, TCAs], kot so nortriptilin, amitriptilin in imipramin) in zlasti če imajo ozek terapevtski indeks (kot na primer s flekainidom, propafenonom in metoprololom), svetujemo previdnost.
English: A randomised, double-blind, placebo-controlled study was performed in 272 patients aged 7-17 years with generalised anxiety disorder.
Slovenian: Pri 272 bolnikih z generalizirano anksiozno motnjo, starih od 7 do 17 let, so opravili randomizirano,
English: Overall, Xeristar's efficacy has been demonstrated at daily doses between 60 and 120 mg in a total of five out of seven randomised, double-blind, placebo-controlled, fixed dose acute studies in adult outpatients with major depressive disorder.
Slovenian: 120 mg v skupaj petih od sedmih randomiziranih dvojno slepih s placebom kontroliranih akutnih preskušanjih z določenim odmerkom pri odraslih bolnikih z veliko depresivno motnjo, zdravljenih ambulantno.
English: 28 hard gastro-resistant capsules 7 hard gastro-resistant capsules
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 28 trdih gastrorezistentnih kapsul 7 trdih gastrorezistentnih kapsul
English: Contents of the pack and other information What Xeristar contains
Slovenian: Ob sočasni uporabi zdravila Xeristar in pripravkov rastlinskega izvora, ki vsebujejo šentjanževko
English: Pollakiuria
Slovenian: Dojenje
English: Each capsule contains 30 mg of duloxetine (as hydrochloride).
Slovenian: Ena kapsula vsebuje 30 mg duloksetina v obliki duloksetinijevega klorida.
English: Package leaflet: information for the user Xeristar 30 mg hard gastro-resistant capsules Xeristar 60 mg hard gastro-resistant capsules
Slovenian: Navodilo za uporabo Xeristar 30 mg trde gastrorezistentne kapsule Xeristar 60 mg trde gastrorezistentne kapsule duloksetin (v obliki duloksetinijevega klorida)
English: Uncommon side effects (may affect up to 1 in 100 people)
Slovenian: Pogosti neželeni učinki (se lahko pojavijo pri največ 1 od 10 bolnikov)
English: The incidence of relapse during the 6-months double-blind follow-up period was 17% and 29% for duloxetine and placebo, respectively.
Slovenian: oziroma 29 % ob uporabi duloksetina oziroma placeba.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 17. december 2004
English: Content (concentration) Package size
Slovenian: Vsebina (koncentracija) Velikost pakiranja ampula (steklo) 3 ml
English: EU Number Invented name Strength Pharmaceutical form Route of administration Packaging
Slovenian: Farmacevtska oblika Pot uporabe Ovojnina
English: 3 vials l t o r
Slovenian: 3 viale k s
English: Vial (glass)
Slovenian: 3 ampule viala (steklo)
English: This overview was last updated in 09-2019.
Slovenian: Povzetek je bil nazadnje posodobljen 09-2019.
English: The safety profile was similar for all the diseases and was considered acceptable.
Slovenian: Varnostni profil je bil podoben za vse bolezni in je bil ocenjen kot sprejemljiv.
English: Soliris is given weekly initially and then every two or three weeks.
Slovenian: Zdravilo Soliris se na začetku daje tedensko, nato pa vsaka dva ali tri tedne.
English: Soliris (eculizumab)
Slovenian: Soliris (ekulizumab)
English: Further information on Soliris can be found on the Agency's website: ema.europa.eu/medicines/human/EPAR/Soliris.
Slovenian: Nadaljnje informacije za zdravilo Soliris so na voljo na spletni strani agencije: ema.europa.eu/medicines/human/EPAR/Soliris.
English: Further information on the orphan designations can be found on the European Medicines Agency's website (PNH: 17 October 2003; aHUS: 24 July 2009; myasthenia gravis: 29 July 2014; NMOSD: 24 April 2019).
Slovenian: Nadaljnje informacije glede določitve zdravila sirote lahko najdete na spletni strani Evropske agencije za zdravila (PNH: 17. oktober 2003; aHUS: 24. julij 2009; miastenija gravis: 29. julij 2014; NMOSD: 24. april 2019).
English: The main measure of effectiveness was the time it took until a certain number of patients experienced a relapse.
Slovenian: Glavno merilo učinkovitosti je bil čas, ki je pretekel, dokler pri določenem številu bolnikov ni prišlo do ponovitve bolezni.
English: A reduction in the score by 2 points indicates a clinically significant improvement of the patient's condition.
Slovenian: Za 2 točki nižji rezultat kaže klinično pomembno izboljšanje bolnikovega stanja.
English: Soliris received a marketing authorisation valid throughout the EU on 20 June 2007.
Slovenian: Za zdravilo Soliris je bilo 20. junija 2007 izdano dovoljenje za promet, veljavno po vsej EU.
English: In case of any infusion-related reactions, the doctor may slow down or stop the infusion.
Slovenian: Če se pojavijo kakršne koli z infuzijo povezane reakcije, lahko zdravnik infuzijo upočasni ali zaustavi.
English: What measures are being taken to ensure the safe and effective use of Soliris?
Slovenian: Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Soliris?
English: The European Medicines Agency decided that Soliris' benefits are greater than its risks and it can be authorised for use in the EU.
Slovenian: Evropska agencija za zdravila je zaključila, da so koristi zdravila Soliris večje od z njim povezanih tveganj in da se lahko odobri za uporabo v EU.
English: It is used in patients who have an antibody called AQP4 and whose disease is relapsing (where the patient has attacks [relapses] between periods with no symptoms).
Slovenian: Uporablja se pri bolnikih, ki imajo protitelo, imenovano AQP4, in katerih bolezen je recidivna (če ima bolnik napade [recidive] med obdobji brez simptomov).
English: Other information about Soliris
Slovenian: Druge informacije o zdravilu Soliris
English: The most common side effect with Soliris (which may affect more than 1 in 10 people) is headache.
Slovenian: Najpogostejši neželeni učinek zdravila Soliris (ki se lahko pojavi pri več kot 1 od 10 bolnikov) je glavobol.
English: In some patients who receive plasma exchange (the removal, treatment and return of their own blood plasma) or infusion of plasma, additional doses of Soliris are required.
Slovenian: Pri nekaterih bolnikih, pri katerih poteka izmenjava plazme (odstranitev, zdravljenje in vrnitev njihove lastne krvne plazme) ali ki prejmejo infuzijo plazme, so potrebni dodatni odmerki zdravila Soliris.
English: Patients will also be given a special card that explains the symptoms of certain types of infection, instructing patients to seek medical care immediately if they experience them.
Slovenian: Bolniki bodo dobili tudi posebno kartico, ki vsebuje razlago simptomov določenih vrst okužb, in navodilo, naj ob pojavu teh simptomov nemudoma poiščejo medicinsko pomoč.
English: What benefits of Soliris have been shown in studies?
Slovenian: Kakšne koristi zdravila Soliris so se pokazale v študijah?
English: The most serious side effect, which may affect up to 1 in 100 people, is meningococcal sepsis (when bacteria and their toxins circulate in the blood and damage the organs).
Slovenian: Najresnejši neželeni učinek, ki se lahko pojavi pri največ 1 od 100 bolnikov, je meningokokna sepsa (če bakterije in njihovi toksini krožijo v krvi in poškodujejo organe).
English: Soliris was shown to benefit patients with these rare diseases.
Slovenian: Zdravilo Soliris se je izkazalo kot koristno pri bolnikih s temi redkimi boleznimi.
English: Why is Soliris authorised in the EU?
Slovenian: Zakaj je bilo zdravilo Soliris odobreno v EU?
English: The main measures of effectiveness were the effect of Soliris on blood levels of haemoglobin and the need for transfusions.
Slovenian: Glavni merili učinkovitosti sta bili učinek zdravila Soliris na ravni hemoglobina v krvi in potreba po transfuziji.
English: These diseases are rare, and Soliris was designated an ‘orphan medicine' (a medicine used in rare diseases).
Slovenian: Te bolezni so redke, zato je bilo zdravilo Soliris določeno kot „zdravilo sirota“ (zdravilo za zdravljenje redkih bolezni).
English: The medicine can only be obtained with a prescription and must be given under the supervision of a doctor who has experience in the management of patients with kidney disorders and disorders affecting the nervous system or the blood.
Slovenian: Predpisovanje in izdaja zdravila je le na recept, daje pa se lahko le pod nadzorom zdravnika, ki ima izkušnje z zdravljenjem bolnikov z boleznimi ledvic in boleznimi, ki prizadenejo živčni sistem ali kri.
English: The company that markets Soliris will ensure that distribution of the medicine occurs only after checking that the patient has been vaccinated appropriately.
Slovenian: Podjetje, ki trži zdravilo Soliris, bo zagotovilo, da se lahko zdravilo izda šele potem, ko se preveri, ali je bil bolnik ustrezno cepljen.
English: As for all medicines, data on the use of Soliris are continuously monitored.
Slovenian: Tako kot za vsako zdravilo se tudi podatki o uporabi zdravila Soliris spremljajo.
English: Patients are monitored for any reactions during the infusion and for at least one hour afterwards.
Slovenian: Pri bolnikih je treba preverjati, ali med infuzijo in še najmanj eno uro po njej ni prišlo do pojava kakršnih koli reakcij.
English: In comparison, none of the 44 patients receiving placebo had stable haemoglobin levels, and they needed an average of 10 transfusions.
Slovenian: V primerjavi s tem nobeden od 44 bolnikov, ki so prejemali placebo, ni imel stabilnih ravni hemoglobina, povprečno pa so potrebovali deset transfuzij.
English: An overview of Soliris and why it is authorised in the EU
Slovenian: Pregled zdravila Soliris in zakaj je odobreno v EU
English: Side effects reported with Soliris are carefully evaluated and any necessary action taken to protect patients.
Slovenian: Neželeni učinki, o katerih so poročali pri zdravilu Soliris, se skrbno ovrednotijo in po potrebi se sprejmejo ukrepi za zaščito bolnikov.
English: Treatment with Soliris improved patients' symptoms and their ability to undertake daily activities based on a standard scoring system.
Slovenian: Z zdravljenjem z zdravilom Soliris so se simptomi bolnikov izboljšali, izboljšala pa se je tudi njihova sposobnost za izvajanje vsakodnevnih opravil glede na standardni sistem točkovanja.
English: The company will also provide prescribers and patients with information on the safety of the medicine, and will send reminders to prescribers and pharmacists to check if any further vaccination is needed for patients taking Soliris.
Slovenian: Zdravnikom, ki predpisujejo zdravilo, in bolnikom bo družba priskrbela tudi informacije o varnosti zdravila ter poslala opomnike zdravnikom, ki predpisujejo zdravilo, in farmacevtom, da preverijo, ali je za bolnike, ki prejemajo zdravilo Soliris, potrebno kakršno koli dodatno cepljenje.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Soliris have also been included in the summary of product characteristics and the package leaflet.
Slovenian: Priporočila in varnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Soliris upoštevati zdravstveni delavci in bolniki, so vključeni tudi v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo.
English: In addition, 76% achieved haematological normalisation (levels of platelets and LDH within normal levels).
Slovenian: Poleg tega je bila pri 76 % bolnikov dosežena hematološka normalizacija (ravni trombocitov in LDH znotraj običajnih ravni).
English: These are life-threatening genetic diseases that cause the breakdown of red blood cells resulting in various medical complications.
Slovenian: To sta življenjsko nevarni prirojeni bolezni, pri katerih se razgrajujejo rdeče krvne celice, kar povzroča različne zdravstvene težave.
English: Haemoglobin is the protein in red blood cells that carries oxygen around the body.
Slovenian: Hemoglobin je beljakovina v rdečih krvnih celicah, ki prenaša kisik po telesu.
English: The study found that treatment with Soliris for 6 months led to clinically meaningful reductions in levels of LDH, indicating reduced breakdown of red blood cells.
Slovenian: V študiji so odkrili, da je šestmesečno zdravljenje z zdravilom Soliris povzročilo klinično pomembna znižanja ravni LDH, kar kaže na upočasnitev razpadanja rdečih krvnih celic.
English: What are the risks associated with Soliris?
Slovenian: Kakšna tveganja so povezana z zdravilom Soliris?
English: What is Soliris and what is it used for?
Slovenian: Kaj je zdravilo Soliris in za kaj se uporablja?
English: The first study involved 17 patients with aHUS who did not respond to or could not be treated with plasma exchange or infusion.
Slovenian: Prva študija je vključevala 17 bolnikov s to boleznijo, ki se niso odzvali na izmenjavo plazme ali infuzijo ali jih niso mogli zdraviti z njima.
English: By blocking the C5 complement protein, eculizumab prevents complement proteins from damaging cells, thereby helping to relieve the symptoms of these diseases.
Slovenian: Ekulizumab z zaviranjem beljakovine komplementa C5 preprečuje, da bi njegova beljakovina poškodovala celice, kar pomaga lajšati simptome teh bolezni.
English: Soliris should be given for life unless the patient develops serious side effects.
Slovenian: Zdravilo Soliris je treba dajati vse življenje, razen če se pri bolniku pojavijo resni neželeni učinki.
English: The second study, involving 20 patients with aHUS who were already receiving plasma exchange or infusion, resulted in 80% of the patients no longer requiring plasma exchange, infusion or dialysis and 90% of the patients achieving haematological normalisation after treatment with Soliris.
Slovenian: V drugi študiji, v katero je bilo vključenih 20 bolnikov z atipičnim hemolitično-uremičnim sindromom, ki so že prejemali izmenjavo plazme ali infundiranje, 80 % bolnikov po zdravljenju z zdravilom Soliris ni več imelo potrebe po izmenjavi plazme, infuziji ali dializi, 90 % bolnikov pa je doseglo hematološko normalizacijo.
English: Soliris is a medicine used to treat adults and children with paroxysmal nocturnal haemoglobinuria (PNH) and atypical haemolytic uraemic syndrome (aHUS).
Slovenian: Soliris je zdravilo, ki se uporablja za zdravljenje odraslih in otrok z paroksizmalno nočno hemoglobinurijo (PNH) in atipičnim hemolitično-uremičnim sindromom (aHUS).
English: The active substance in Soliris, eculizumab, is a monoclonal antibody (a type of protein) that has been designed to attach to the C5 complement protein, which is a part of the body's defence system called the ‘complement system'.
Slovenian: Učinkovina zdravila Soliris, ekulizumab, je monoklonsko protitelo (vrsta beljakovine), ki je bilo zasnovano tako, da se veže na beljakovino komplementa C5, ki je del obrambnega sistema telesa, imenovanega „sistem komplementa“.
English: A registry study of patients with PNH who had never had a blood transfusion looked at the blood levels of the enzyme lactate dehydrogenase (LDH).
Slovenian: V študiji registra bolnikov s paroksizmalno nočno hemoglobinurijo, ki nikoli niso prejeli transfuzije krvi, so preučevali ravni encima laktat dehidrogenaza (LDH) v krvi.
English: Soliris is given as an infusion (drip) into a vein and the recommended dose depends on what it is used for, and for patients under 18 years of age, on their bodyweight.
Slovenian: Zdravilo Soliris se daje z infundiranjem (kapalno infuzijo) v veno, priporočeni odmerek pa je odvisen od tega, za kaj se zdravilo uporablja, pri bolnikih, mlajših od 18 let, pa tudi od njihove telesne mase.
English: PNH results in anaemia (low red blood cell counts), thrombosis (blood clots in the blood vessels), pancytopenia (low counts of blood cells) and dark urine, while aHUS results in anaemia, thrombocytopenia (a decrease in the number of platelets, components that help the blood to clot) and kidney failure.
Slovenian: Posledice paroksizmalne nočne hemoglobinurije so slabokrvnost (nizko število rdečih krvnih celic), tromboza (nastajanje krvnih strdkov v ožilju), pancitopenija (nizko število krvnih celic) in temen urin, medtem ko so posledica atipičnega hemolitično-uremičnega sindroma slabokrvnost, trombocitopenija (zmanjšanje števila trombocitov, tj. krvnih ploščic, ki pomagajo pri strjevanju krvi) in odpoved ledvic.
English: The third study involved 30 patients with aHUS who had received at least one dose of Soliris.
Slovenian: Tretja študija je vključevala 30 bolnikov z atipičnim hemolitično-uremičnim sindromom, ki so prejeli vsaj en odmerek zdravila Soliris.
English: Soliris is used to treat adults with myasthenia gravis (a disease where the immune system attacks and damages muscle cells causing muscle weakness), in whom other medicines do not work and who have a specific antibody in their body called AChR antibody.
Slovenian: Zdravilo Soliris se uporablja za zdravljenje odraslih z miastenijo gravis (boleznijo, pri kateri imunski sistem napada in poškoduje mišične celice, kar povzroča mišično oslabelost), pri katerih druga zdravila ne delujejo in ki imajo v telesu specifično protitelo, imenovano protitelo AChR.
English: After around 22 months on average, 3% of patients treated with Soliris had had a relapse, whereas 43% of patients treated with placebo had already had a relapse after around 9 months on average.
Slovenian: Po povprečno približno 22 mesecih je do ponovitve bolezni prišlo pri 3 % bolnikov, ki so prejemali zdravilo Soliris, medtem ko je pri 43 % bolnikov, ki so prejemali placebo, prišlo do ponovitve bolezni v povprečju po približno devetih mesecih.
English: Treatment with Soliris over 26 weeks led to stable haemoglobin levels in 49% of the patients (21 out of 43), without the need for transfusions of red blood cells.
Slovenian: Zdravljenje z zdravilom Soliris je v 26 tednih stabiliziralo ravni hemoglobina pri 49 % (21 od 43) bolnikov, pri tem pa ni bilo potrebe po transfuziji rdečih krvnih celic.
English: In a study in 7 children with PNH who had had at least one transfusion in the previous two years, all patients received Soliris.
Slovenian: V študiji pri sedmih otrocih s paroksizmalno nočno hemoglobinurijo, ki so v preteklih dveh letih prejeli vsaj eno transfuzijo, so zdravilo Soliris prejeli vsi bolniki.
English: For the full list of side effects and restrictions with Soliris, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov in omejitev pri uporabi zdravila Soliris glejte navodilo za uporabo.
English: For aHUS, Soliris was studied in three main studies involving 67 patients.
Slovenian: Pri atipičnem hemolitično-uremičnem sindromu so zdravilo Soliris proučevali v treh glavnih študijah, ki so vključevale 67 bolnikov.