FrancophonIA/ELRC3.0 huggingface dataset:
English: 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Estonian: 4.10 Üleannustamine (sümptomid, esmaabi, antioodid), vajadusel
English: This hypertrophy does not seem to be linked to any pathology and was observed to be reversible upon discontinuation of the treatment.
Estonian: See hüpertroofia ei ole tõenäoliselt seotud ühegi patoloogiaga ja täheldati, et see on ravi katkestamisel pöörduv.
English: THE WORDS “FOR ANIMAL TREATMENT ONLY” AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, IF APPLICABLE
Estonian: MÄRGE „AINULT VETERINAARSEKS KASUTAMISEKS“ NING TINGIMUSED VÕI PIIRANGUD TARNIMISE JA KASUTAMISE OSAS, KUI NEED ON KOHALDATUD
English: This is thought to be due to activation of feedback mechanisms without adverse clinical consequence.
Estonian: See on tingitud tagasiside mehhanismide aktivatsioonist ilma kahjulike kliiniliste tagajärgedeta.
English: (benazeprilum HCl)
Estonian: (benazeprili HCl)
English: It also allowed a quicker improvement of cough and activity and a slower degradation of cough, heart sounds and appetite.
Estonian: Samuti võimaldas see kiiremat köhast paranemist ja aktiivsust ning aeglasemat köha, südamehelide ja isu halvenemist.
English: Tres le Bois 22600 Loudeac France
Estonian: Tres le Bois 22600 Loudeac Prantsusmaa
English: The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Estonian: Ravimi trükitud pakendi infolehel peab olema vastava ravimpartii vabastamise eest vastutava tootja nimi ja aadress.
English: 30 tablets 90 tablets
Estonian: 30 tabletti 90 tabletti
English: White plastic (HDPE) bottle with a child-resistant closure in a cardboard box.
Estonian: Valgest plastikust (HDPE) lastekindla korgiga pudel pappkarbis.
English: This fixed combination product should only be used in dogs which require both active substances to be administered concomitantly at this fixed dose.
Estonian: Fikseeritud annusega kombinatsiooni tuleb kasutada ainult nendel koertel, kes vajavad mõlemat toimeainet koosmanustatuna selles fikseeritud annuses.
English: Pregnant women should take special care to avoid accidental oral exposure because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Estonian: Rasedad naised peavad olema eriti ettevaatlikud, et vältida juhuslikku suukaudset kokkupuudet, sest AKE inhibiitoritel on näidatud raseduse ajal mõju sündimata lapsele.
English: Secretion of aldosterone can also be stimulated by factors other than Angiotensin-II, notably K+ increase or ACTH.
Estonian: Aldosterooni vabanemist võivad stimuleerida ka teised tegurid peale angiotensiin II, eriti K+ tõus või AKTH.
English: This veterinary medicinal product does not require any special storage conditions.
Estonian: See veterinaarravimpreparaat ei vaja säilitamisel eritingimusi.
English: Due to the antiandrogenic effect of spironolactone, it is not recommended to administer the veterinary medicinal product to growing dogs.
Estonian: Tänu spironolaktooni antiandrogeensele toimele ei ole veterinaarravimi manustamine soovitatav kasvavatele koertele.
English: Therefore, dogs treated concomitantly with an NSAID should be closely monitored and correctly hydrated.
Estonian: Seega peab koeri, kellele manustatakse samal ajal MSPVA-sid, hoolikalt jälgima ja nõuetekohaselt hüdreerima.
English: In case of the accidental ingestion by a dog of many Cardalis chewable tablets, there is no specific antidote or treatment.
Estonian: Kui koer neelab juhuslikult alla mitu Cardalise närimistabletti, ei ole sellele spetsiifilist antidooti või ravi.
English: Artificial beef flavour Compressible sugar Crospovidone Magnesium stearate
Estonian: Kunstlik veiseliha maitseaine Kokkupressitud suhkur Krospovidoon
English: It is therefore recommended to induce vomiting, and then carry out gastric lavage (depending on the risk assessment) and monitor electrolytes.
Estonian: Seetõttu on soovitatav kutsuda esile oksendamine ning siis teha maoloputus (sõltuvalt riski hindamisest) ja jälgida elektrolüütide sisaldust.
English: D-73614 Schorndorf Germany
Estonian: D-73614 Schorndorf Saksamaa
English: However, this very slight decrease was transient, the red cell mass remained within the normal range, and the finding was not considered to be of clinical importance.
Estonian: Kuid see kerge vähenemine oli mööduv, erütrotsüütide mass jäi normi piiridesse ja seda leidu ei loeta kliiniliselt oluliseks.
English: Dogs.
Estonian: Koerad.
English: ANNEX III LABELLING AND PACKAGE LEAFLET
Estonian: LISA III PAKENDI MÄRGISTUS JA PAKENDI INFOLEHT
English: Spironolactone decreases digoxin elimination and hence raises digoxin plasma concentration.
Estonian: Spironolaktoon vähendab digoksiini eritumist ja seetõttu suurendab digoksiini plasmakontsentratsiooni.
English: Benazeprilat is a highly potent and selective inhibitor of angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I to active angiotensin II.
Estonian: Benaseprilaat on tugev ja selektiivne angiotensiini konverteeriva ensüümi (AKE) inhibiitor, takistades mitteaktiivse angiotensiin I konverteerimist aktiivseks angiotensiin II-ks.
English: The association of spironolactone and benazepril is beneficial as both act on the renin-angiotensinaldosterone system (RAAS) but at different levels along the cascade.
Estonian: Spironolaktooni ja benasepriili kooslus on kasulik, sest mõlemad toimivad reniini-angiotensiinialdosterooni süsteemile (RAAS), kuid kaskaadi erinevatel tasemetel.
English: The product causes a long-lasting inhibition of plasma ACE activity in dogs, with more than 95% inhibition at peak effect and significant activity (>80%) persisting 24 hours after dosing.
Estonian: Ravim põhjustab koertel pikaajalise plasma AKE aktiivsuse inhibeerimise rohkem kui 95% inhibitsiooni maksimaalse toime juures ja oluline aktiivsus (> 80%) püsib 24 tundi pärast manustamist.
English: Lactose monohydrate Cellulose microcrystalline Povidone K30
Estonian: Laktoosmonohüdraat Mikrokristalne tselluloos Povidoon K30
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system, ACE inhibitors, combinations.
Estonian: Farmakoterapeutiline rühm: reniin-angiotensiinsüsteemi toimivad ained, AKE inhibiitorid, kombinatsioon
English: EXP {month/year} Once opened, use within 6 months.
Estonian: EXP Pärast pakendi avamist kasutada kuni 6 kuud.
English: In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Estonian: Juhuslikul ravimi allaneelamisel pöörduda viivitamatult arsti poole ja näidata arstile pakendi infolehte või pakendi etiketti.
English: Do not use during pregnancy and lactation (see section "Pregnancy and lactation ").
Estonian: Mitte kasutada tiinuse ja imetamise ajal (vt punkt „Tiinus ja laktatsioon“).
English: Therefore, to achieve a more complete inhibition of the deleterious effects of RAAS overactivity which occurs with heart failure, it is recommended to use aldosterone antagonists, such as spironolactone, concomitantly with ACE inhibitors to block specifically the activity of aldosterone (regardless of the source), through competitive antagonism on mineralocorticoid receptors.
Estonian: Seega, et saavutada täielik RAAS-i üleaktiivsuse kahjustavate toimete inhibeerimine, mis ilmneb südamepuudulikkusega, on soovitatav kasutada koos AKE inhibiitoritega aldosterooni antagoniste, näiteks spironolaktooni, et spetsiifiliselt blokeerida aldosterooni aktiivsus (sõltumata allikast) läbi mineralokortikoidretseptorite konkureeriva antagonismi.
English: Benazeprilat concentrations decline biphasically: the initial fast phase represents elimination of free drug, while the terminal phase reflects the release of benazeprilat that was bound to ACE, mainly in the tissues.
Estonian: Benaseprilaadi kontsentratsioonid vähenevad bifaasiliselt: esialgne kiire faas kujutab vaba ravimi eritumist, samas kui terminaalne faas peegeldab AKE-ga seotud benaseprilaadi vabanemist peamiselt kudedes.
English: Therefore, the product should be used with caution with other veterinary medicinal products which induce, inhibit, or which are metabolised by these enzymes.
Estonian: Seetõttu tuleb seda ravimit kasutada ettevaatlikult koos teiste veterinaarravimitega, mis indutseerivad ja inhibeerivad neid ensüüme või mis metaboliseeruvad nende ensüümide toimel.
English: The tablets are packed bottles of 30 tablets or 90 tablets, and each bottle is presented in an outer cardboard box.
Estonian: Tabletid on pakendatud 30 või 90 kaupa pudelitesse ja iga pudel paigutatud välimisse pappkarpi.
English: THE WORDS “KEEP OUT OF THE SIGHT AND REACH OF CHILDREN”
Estonian: MÄRGE „HOIDA LASTE EEST VARJATUD JA KÄTTESAAMATUS KOHAS“
English: Repeated administration of benazepril leads to slight bioaccumulation of benazeprilat, steady state being achieved within few days.
Estonian: Benasepriili korduvmanustamine toob kaasa kerge benaseprilaadi bioakumulatsiooni, püsikontsentratsioon saavutatakse mõne päevaga.
English: Spironolactone and its active metabolites (including 7-α-thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone by binding competitively to mineralocorticoid receptors located in the kidneys, heart and blood vessels.
Estonian: Spironolaktoon ja tema aktiivsed metaboliidid (sealhulgas 7-α-tiometüülspironolaktoon ja kanrenoon) toimivad kui spetsiifilised aldosterooni antagonistid, seondudes konkureerivalt neerudes, südames ja veresoontes asuvate mineralokortikoidi retseptoritega.
English: In the cardiovascular system, spironolactone prevents the detrimental effects of aldosterone.
Estonian: Spironolaktoon ennetab kardiovaskulaarsüsteemis aldosterooni kahjulikke toimeid.
English: The mean residence time of the metabolites ranges from 9 to 14 hours and they are preferentially distributed to the gastro-intestinal tract, kidney, liver and adrenal glands.
Estonian: Metaboliitide keskmine residentsusaeg on vahemikus 9…14 tundi ning jaotuvad eelistatult seedetrakti, neerudesse, maksa ja neerupealistesse.
English: Spironolactone may cause both induction and inhibition of cytochrome P450 enzymes and could affect the metabolism of other substances utilizing these metabolic pathways.
Estonian: Spironolaktoon võib nii indutseerida kui ka inhibeerida tsütokroom P450 ensüüme ja võib mõjutada teiste seda metabolismirada kasutavate ainete biotransformatsiooni.
English: The result is an improvement in heart function.
Estonian: Tulemuseks on südamefunktsiooni paranemine.
English: THE WORDS “FOR ANIMAL TREATMENT ONLY”
Estonian: MÄRGE „AINULT VETERINAARSEKS KASUTAMISEKS“
English: After oral administration of spironolactone to dogs, it was demonstrated that the three metabolites achieved levels of 32 to 49% of the administered dose.
Estonian: Pärast spironolaktooni suukaudset manustamist koertele näidati, et kolm metaboliiti saavutasid taseme 32…49% manustatud annusest.
English: EU/2/12/142/001(1 x 30 tablets, 2.5 mg/20 mg) EU/2/12/142/002 (1 x 90 tablets, 2.5 mg/20 mg) EU/2/12/142/003 (1 x 30 tablets, 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tablets, 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tablets, 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tablets, 10 mg/80 mg)
Estonian: EU/2/12/142/001 (1 × 30 tabletti, 2,5 mg / 20 mg) EU/2/12/142/002 (1 × 90 tabletti, 2,5 mg / 20 mg) EU/2/12/142/003 (1 × 30 tabletti, 5 mg / 40 mg) EU/2/12/142/004 (1 × 90 tabletti, 5 mg / 40 mg) EU/2/12/142/005 (1 × 30 tabletti, 10 mg / 80 mg) EU/2/12/142/006 (1 × 90 tabletti, 10 mg / 80 mg)
English: The tablets can be divided into equal halves.
Estonian: Pruunid piklikud poolitusjoonega maitsestatud närimistabletid Tableti saab jagada võrdseteks osadeks.
English: Pack sizes of 30 or 90 tablets.
Estonian: Pakendis on 30 või 90 tabletti.
English: Benazepril, by preventing the formation of Angiotensin-II, inhibits the detrimental effects of vasoconstriction and stimulation of aldosterone release.
Estonian: Benasepriil takistab angiotensiin II moodustumist ning inhibeerib vasokonstriktsiooni kahjulikke toimeid ja aldosterooni vabanemise stimulatsiooni.
English: The clearance of benazeprilat is not affected in dogs with impaired renal function and therefore no adjustment of benazepril dose is required in cases of renal insufficiency
Estonian: Benaseprilaadi kliirens ei mõjuta neerufunktsiooni häirega koertel neerufunktsiooni ja seega ei ole neerupuudulikkuse korral benasepriili annuse kohandamine vajalik.
English: SPECIAL STORAGE CONDITIONS
Estonian: Säilitamise eritingimused
English: 4.4 Special warnings
Estonian: 4.4 Erihoiatused
English: However, aldosterone release is not fully controlled by ACE Inhibitors because Angiotensin-II is also produced by non-ACE pathways such as chymase (phenomenon known as “aldosterone breakthrough”).
Estonian: Kuid aldosterooni vabanemine ei ole AKE inhibiitorite poolt täielikult kontrollitav, sest angiotensiin II toodetakse ka mitte-AKE-radade, nagu näiteks kümaaside poolt (nähtus, mida nimetatakse kui aldosterooni läbimurre).
English: Do not use in case of hypersensitivity to Angiotensin-Converting Enzyme inhibitors (ACE inhibitors) or to any of the excipients.
Estonian: Mitte kasutada, kui esineb ülitundlikkus angiotensiini konverteeriva ensüümi inhibiitorite (AKE inhibiitorite) või ravimi ükskõik milliste abiainete suhtes.
English: The pharmacokinetics of spironolactone are based on its metabolites, as the parent compound is unstable at assay.
Estonian: Spironolaktooni farmakokineetika põhineb tema metaboliitidel, sest lähteaine on testides ebastabiilne.
English: Unchanged benazepril and hydrophilic metabolites account for the remainder.
Estonian: Muutumatul kujul benasepriil ja hüdrofiilsed metaboliidid moodustavad ülejäänud osa.
English: In experimental models in dogs, it was shown that long term therapy with an aldosterone antagonist prevents progressive left ventricle dysfunction and attenuates left ventricle remodelling in dogs with chronic heart failure.
Estonian: Eksperimentaalsetes koertel tehtud mudelites näidati, et pikaajaline ravi aldosterooni antagonistidega ennetab progresseeruvat vasaku vatsakese talitlushäiret ja pidurdab vasaku vatsakese remodelleerumist kroonilise südamepuudulikkusega koertel.
English: Aldosterone promotes myocardial fibrosis, myocardial and vascular remodelling and endothelial dysfunction, although the precise mechanism of action is not yet clearly defined.
Estonian: Aldosteroon soodustab südamelihase fibroosi, müokardi ja veresoonte remodelleerumist ning endoteeli talitlushäiret, kuigi täpne toimemehhanism ei ole selgelt määratletud.
English: Spironolactone is mainly excreted via its metabolites.
Estonian: Spironolaktoon eritub peamiselt metaboliitidena.
English: The resulting reduction in extracellular volume decreases the cardiac preload and left atrial pressure.
Estonian: Kaasnev ekstratsellulaarse mahu vähenemine vähendab südame eelkoormust ja vasaku vatsakese rõhku.
English: MARKETING AUTHORISATION HOLDER
Estonian: Müügiloa hoidja:
English: Spironolactone is rapidly and completely metabolised by the liver into its active metabolites, 7αthiomethyl-spironolactone and canrenone, which are the primary metabolites in the dog.
Estonian: Spironolaktoon metaboliseeritakse maksas kiiresti ja täielikult aktiivseteks metaboliitideks 7α-tiometüülspironolaktooniks ja kanrenooniks, mis on koeral peamisteks metaboliitideks.
English: After the oral administration of radiolabelled spironolactone to the dog, 70% of the dose is recovered in faeces and 20% in the urine.
Estonian: Pärast radioaktiivselt märgistatud spironolaktooni suukaudset manustamist koertele on 70% annusest roojas ja 20% uriinis.
English: Benazepril and benazeprilat are rapidly distributed, mainly in liver and kidney.
Estonian: Benasepriil ja benaseprilaat jaotuvad kiiresti, peamiselt maksa ja neerudesse.
English: Therefore, it blocks effects mediated by angiotensin II, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney.
Estonian: Seetõttu blokeeritakse angiotensiin II vahendatud toimed, sealhulgas nii arterite kui ka veenide ahenemine ning naatriumi- ja veepeetus neerude poolt.
English: The mean volumes of distribution of 7-α-thiomethyl-spironolactone and canrenone are approximately 153 litres and 177 litres respectively.
Estonian: 7-α-tiometüülspironolaktooni ja kanrenooni keskmised jaotusruumalad on vastavalt umbes 153 ja 177 liitrit.
English: The tablets should be administered either mixed with a small amount of food offered to the dog just prior to the main meal, or with the meal itself.
Estonian: Tabletid tuleb manustada kas segatuna väikese koguse toiduga enne koera põhitoidukorda või koos toidukorra endaga.
English: The administration of deoxycorticosterone with the product may lead to a moderate reduction of the natriuretic effects (reduction of urinary sodium excretion) of spironolactone.
Estonian: Deoksükortikosterooni koosmanustamine selle ravimiga võib tuua kaasa spironolaktooni natriureetilise toime mõõduka vähenemise (naatriumi eritumise vähenemine uriiniga).
English: Unlike in humans, an increased incidence of hyperkalaemia was not observed in clinical trials performed in dogs with this combination.
Estonian: Erinevalt inimestest ei täheldatud selle kombinatsiooni kasutamisel koertel kliinilistes katsetes hüperkaleemia suurenenud esinemist.
English: The systemic bioavailability of benazepril is incomplete due to incomplete absorption and first pass metabolism.
Estonian: Benasepriili süsteemne biosaadavus on puudulik tänu mittetäielikule imendumisele ja esmasele passaažile.
English: The product should be used with caution in dogs with hepatic dysfunction because it may alter the extensive biotransformation of spironolactone in liver.
Estonian: Ravimit soovitatakse kasutada ettevaatlikult maksafunktsiooni häirega koertel, sest võib muuta ulatuslikult spironolaktooni biotransformatsiooni maksas.
English: Benazepril and benazeprilat are extensively bound to plasma proteins, and in tissues are found mainly in the liver and kidney.
Estonian: Benasepriil ja benaseprilaat on ulatuslikult seotud plasmavalkudega ning kudedes leidub peamiselt maksas ja neerudes.
English: However, regular monitoring of renal function and serum potassium levels is recommended in dogs with renal impairment, as they may have an increased risk of hyperkalaemia during treatment with this product.
Estonian: Siiski on soovitatav regulaarselt kontrollida neerukahjustusega koertel neerufunktsiooni ja seerumi kaaliumisisaldust, sest neil võib esineda ravi ajal selle preparaadiga suurenenud risk hüperkaleemia tekkeks.
English: Pregnancy and lactation
Estonian: Tiinus ja laktatsion
English: Oral use.
Estonian: Suukaudne manustamine.
English: Do not use in dogs suffering from hypoadrenocorticism, hyperkalaemia or hyponatraemia.
Estonian: Mitte kasutada hüpoadrenokortitsismi, hüperkaleemia või hüponatreemiaga koertel.
English: As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril (hydrochloride) and spironolactone.
Estonian: Kuivõrd digoksiini terapeutiline indeks on väga kitsas, siis on soovitatav jälgida neid koeri hoolikalt, kes saavad digoksiini ja benasepriili (vesinikkloriidina ) ning spironolaktooni kombinatsiooni.
English: OTHER INFORMATION Pack sizes
Estonian: LISAINFO Pakendi suurused
English: As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril hydrochloride and spironolactone.
Estonian: Kuivõrd digoksiini terapeutiline indeks on väga kitsas, siis on soovitatav jälgida neid koeri hoolikalt, kes saavad digoksiini ja benasepriilihüdrokloriidi ning spironolaktooni kombinatsiooni.
English: 80 mg The tablets are brown coloured, palatable, oblong shaped with a score line and chewable.
Estonian: Tabletid on pruunid, pikliku kujuga, poolitusjoonega, maitsestatud ja näritavad.
English: A dose related but moderate compensatory physiological hypertrophy of zona glomerulosa of the adrenal glands was also observed at doses of 3 times and greater of the recommended dose.
Estonian: Täheldati ka annusest sõltuvat mõõdukat kompensatoorset neerupealiste zona glomerulosa hüpertroofiat soovituslikust kolm korda suuremate annuste juures.
English: benazepril HCl 2.5 mg, spironolactone 20 mg benazepril HCl 5 mg, spironolactone 40 mg benazepril HCl 10 mg, spironolactone 80 mg
Estonian: benazeprili HCl 2.5 mg, spironolactonum 20 mg benazeprili HCl 5 mg, spironolactonum 40 mg benazeprili HCl 10 mg, spironolactonum 80 mg
English: Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis.
Estonian: Mitte kasutada, kui esineb aordi- või kopsustenoosist tingitud südame jõudluse vähenemine.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Estonian: Kõrvaltoimete esinemissagedus on defineeritud järgnevalt: - väga sage (kõrvaltoime(d) ilmnes(id) rohkem kui 1-l loomal 10-st ravitud loomast) - sage (rohkem kui 1-l, kuid vähem kui 10-l loomal 100-st ravitud loomast) - aeg-ajalt (rohkem kui 1-l, kuid vähem kui 10-l loomal 1000-st ravitud loomast) - harv (rohkem kui 1-l, kuid vähem kui 10-l loomal 10000-st ravitud loomast) - väga harv (vähem kui 1-l loomal 10000-st ravitud loomast, kaasaarvatud üksikjuhud).
English: The plasma clearances of canrenone and 7-αthiomethyl-spironolactone are 1.5 l/h/kg bw and 0.9 l/h/kg bw respectively.
Estonian: Kanrenooni ja 7-α-tiometüülspironolaktooni plasmakliirensid on vastavalt 1,5 l/h/kg kehamassi kohta ja 0,9 l/h/kg kehamassi kohta.
English: STATEMENT OF ACTIVE SUBSTANCES
Estonian: TOIMEAINETE JA ABIAINETE SISALDUS
English: For the treatment of congestive heart failure caused by chronic degenerative valvular disease in dogs (with diuretic support, as appropriate).
Estonian: Kroonilisest degeneratiivsest südameklapirikkest tingitud südame paispuudulikkuse ravi koertel (vajaduse korral diureetikumi toetusega).
English: Do not administer in conjunction with Non Steroidal Anti-Inflammatory Drugs (NSAIDs) to dogs with renal insufficiency.
Estonian: Mitte kasutada koos mittesteroidsete põletikuvastaste ainetega (MSPVA-dega) neerupuudulikkusega koertel.
English: The tablets contain beef flavouring to improve palatability, and in a field study conducted in dogs with chronic degenerative valvular disease the tablets were voluntarily and fully consumed 92% of the time when offered either with or without food.
Estonian: Kroonilise degeneratiivse südameklapirikkega koerte väliuuringus sõid koerad pakutud tabletid koos toiduga või ilma vabatahtlikult ja täielikult ära 92%-l juhtudest.
English: Ceva Santé Animale 10, av. de la Ballastière 33500 Libourne France
Estonian: Ceva Santé Animale 10, av. de la Ballastière 33500 Libourne Prantsusmaa
English: Ceva Santé Animale 10 av. de La Ballastière 33500 Libourne France
Estonian: Ceva Santé Animale 10 av. de la Ballastière 33500 Libourne Prantsusmaa
English: Clinical studies investigating the survival time demonstrated that the fixed combination increased the life expectancy in dogs with congestive heart failure with a 89% reduction in the relative risk of cardiac mortality assessed in dogs treated with spironolactone in combination with benazepril (hydrochloride) compared to dogs treated with benazepril (hydrochloride) alone (mortality was classified as death or euthanasia due to heart failure).
Estonian: Kliinilised katsed, milles uuriti südamepuudulikkusega koerte elulemust, näitasid, et fikseeritud kombinatsiooni kasutamine suurendas oodatavat eluiga ning 89% südamepuudulikkusesse suremuse riski langust nendel koertel, keda raviti spironolaktooni ja benasepriili (hüdrokloriidina) kombinatsiooniga võrreldes nende koertega, keda raviti ainult benasepriiliga (hüdrokloriidina ) (suremus liigitati kui surm või eutanaasia seoses südamepuudulikkusega).