FrancophonIA/ELRC3.0 huggingface dataset:
English: Organic anion transporting polypeptide (OATP) inhibitors Preclinical studies indicate that aliskiren might be a substrate of organic anion transporting polypeptides.
Slovenian: Zaviralci transportnega polipeptida za organske anione Rezultati predkliničnih študij kažejo, da bi bil aliskiren lahko substrat transportnih polipeptidov za organske anione, zato obstaja pri sočasni uporabi možnost medsebojnega delovanja med zaviralci transportnih polipeptidov za organske anione in aliskirenom (glejte medsebojno delovanje z grenivkinim sokom).
English: EU/1/07/407/007 84 film-coated tablets (3x28) EU/1/07/407/009 98 film-coated tablets (2x49) EU/1/07/407/010 280 film-coated tablets (20x14)
Slovenian: EU/1/07/407/007 84 filmsko obloženih tablet (3x28) EU/1/07/407/009 98 filmsko obloženih tablet (2x49) EU/1/07/407/010 280 filmsko obloženih tablet (20x14)
English: FOLDING BOX FOR UNIT PACK CONTAINING PCTFE/PVC BLISTERS
Slovenian: ŠKATLA ZA POSAMIČNO PAKIRANJE, KI VSEBUJE PCTFE/PVC PRETISNE OMOTE
English: BLISTER BLISTER (CALENDAR)
Slovenian: PRETISNI OMOT PRETISNI OMOT (KOLEDARSKO PAKIRANJE)
English: EU/1/07/407/011 7 film-coated tablets EU/1/07/407/012 14 film-coated tablets EU/1/07/407/013 28 film-coated tablets EU/1/07/407/014 30 film-coated tablets EU/1/07/407/015 50 film-coated tablets EU/1/07/407/016 56 film-coated tablets
Slovenian: EU/1/07/407/011 7 filmsko obloženih tablet EU/1/07/407/012 14 filmsko obloženih tablet EU/1/07/407/013 28 filmsko obloženih tablet EU/1/07/407/014 30 filmsko obloženih tablet EU/1/07/407/015 50 filmsko obloženih tablet EU/1/07/407/016 56 filmsko obloženih tablet
English: When administered with atorvastatin (80 mg), steady-state aliskiren (300 mg) AUC and Cmax increased by
Slovenian: Pri sočasni uporabi atorvastatina (80 mg) in aliskirena (300 mg) sta se AUC in Cmax aliskirena v stanju dinamičnega ravnovesja zvečali za 50 %.
English: EU/1/07/407/017 84 film-coated tablets (3x28) EU/1/07/407/018 90 film-coated tablets (3x30) EU/1/07/407/019 98 film-coated tablets (2x49) EU/1/07/407/020 280 film-coated tablets (20x14)
Slovenian: EU/1/07/407/017 84 filmsko obloženih tablet (3x28) EU/1/07/407/018 90 filmsko obloženih tablet (3x30) EU/1/07/407/019 98 filmsko obloženih tablet (2x49) EU/1/07/407/020 280 filmsko obloženih tablet (20x14)
English: What Sprimeo looks like and contents of the pack Sprimeo 150 mg film coated tablets are light-pink, biconvex round tablets, imprinted “IL” on one side and “NVR” on the other side.
Slovenian: Sprimeo 150 mg filmsko obložene tablete so bikonveksne okrogle tablete svetlo roza barve, z oznako „IL‟ na eni strani in „NVR‟ na drugi.
English: Therefore, if administration of aliskiren in ESRD patients receiving haemodialysis is considered necessary, no dose adjustment is warranted in these patients.
Slovenian: Če bolnik s končno ledvično odpovedjo potrebuje zdravljenje z aliskirenom, ni potrebno prilagajati odmerjanja.
English: Concomitant use of Sprimeo with ARBs or ACEIs is contraindicated in patients with renal impairment (GFR < 60 ml/min/1.73 m2) (see section 4.3).
Slovenian: Sočasna uporaba zdravila Sprimeo in zaviralcev angiotenzinskih receptorjev II ali zaviralcev ACE je kontraindicirana pri bolnikih z okvaro ledvic (GFR < 60 ml/min/1,73 m2) (glejte poglavje 4.3).
English: EU/1/07/407/001 7 film-coated tablets EU/1/07/407/002 14 film-coated tablets EU/1/07/407/003 28 film-coated tablets EU/1/07/407/004 30 film-coated tablets EU/1/07/407/005 50 film-coated tablets EU/1/07/407/006 56 film-coated tablets EU/1/07/407/008 90 film-coated tablets
Slovenian: EU/1/07/407/001 7 filmsko obloženih tablet EU/1/07/407/002 14 filmsko obloženih tablet EU/1/07/407/003 28 filmsko obloženih tablet EU/1/07/407/004 30 filmsko obloženih tablet EU/1/07/407/005 50 filmsko obloženih tablet EU/1/07/407/006 56 filmsko obloženih tablet EU/1/07/407/008 90 filmsko obloženih tablet
English: 7 film-coated tablets 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 50 film-coated tablets 56 film-coated tablets 90 film-coated tablets
Slovenian: 7 filmsko obloženih tablet 14 filmsko obloženih tablet 28 filmsko obloženih tablet 30 filmsko obloženih tablet 50 filmsko obloženih tablet 56 filmsko obloženih tablet 90 filmsko obloženih tablet
English: or an “angiotensin 2 receptor blocker” such as valsartan, telmisartan, irbesartan etc. - if you have impaired kidney function, your doctor will carefully consider whether Sprimeo is suitable for you and may wish to monitor you carefully.
Slovenian: “zaviralci angiotenzinskih receptorjev 2”, kot so valsartan, telmisartan, irbesartan in podobno; - če imate okvarjeno delovanje ledvic bo vaš zdravnik pozorno premislil, ali je zdravilo Sprimeo primerno za vas in vas bo mogoče želel pozorno spremljati; - če pride do angioedema (težav z dihanjem ali s požiranjem ali do otekanja obraza, rok, stopal, oči, ustnic in/ali jezika).
English: Steady-state-plasma concentrations are reached within 5-7 days following once-daily administration and steady-state levels are approximately 2-fold greater than with the initial dose.
Slovenian: Koncentracije v stanju dinamičnega ravnovesja so približno 2-krat višje kot po začetnem odmerku.
English: Sprimeo 300 mg film-coated tablets
Slovenian: Sprimeo 300 mg filmsko obložene tablete
English: Sprimeo 150 mg film-coated tablets
Slovenian: Sprimeo 150 mg filmsko obložene tablete
English: OTHER
Slovenian: ali
English: No adjustment of the initial dose is required for patients with mild to severe hepatic impairment (see section 5.2).
Slovenian: Okvara jeter Bolnikom z blago do hudo okvaro jeter začetnega odmerka ni treba prilagajati (glejte poglavje 5.2).
English: Fertility, pre-natal development and post-natal development were unaffected in rats at doses up to 250 mg/kg/day.
Slovenian: Odmerki do 250 mg/kg/dan pri podganah niso vplivali na plodnost ter na razvoj ploda pred skotitvijo in po njej.
English: What Sprimeo looks like and contents of the pack Sprimeo 300 mg film coated tablets are light-red, biconvex, ovaloid tablets, imprinted “IU” on one side and “NVR” on the other side.
Slovenian: Sprimeo 300 mg filmsko obložene tablete so bikonveksne ovalne tablete svetlo rdeče barve, z oznako „IU‟ na eni strani in „NVR‟ na drugi.
English: Light-pink, biconvex, round tablet, imprinted “IL” on one side and “NVR” on the other side.
Slovenian: Bikonveksna okrogla tableta svetlo roza barve, z vtisnjeno oznako „IL‟ na eni strani in „NVR‟ na drugi.
English: Sprimeo is not recommended in patients with severe renal impairment (glomerular filtration rate (GFR) < 30 ml/min/1.73 m2).
Slovenian: Pri bolnikih s hudo okvaro ledvic (s hitrostjo glomerulne filtracije (GFR) < 30 ml/min/1,73 m2) uporaba zdravila Sprimeo ni priporočena.
English: Timing of haemodialysis did not significantly alter the pharmacokinetics of aliskiren in ESRD patients.
Slovenian: Časovni razpored dialize ni bistveno vplival na farmakokinetiko aliskirena pri bolnikih s končno ledvično odpovedjo.
English: Adverse reactions have generally been mild and transient in nature and have only infrequently required discontinuation of therapy.
Slovenian: Neželeni učinki so bili na splošno blagi in prehodnega značaja.
English: Light-red, biconvex, ovaloid tablet, imprinted “IU” on one side and “NVR” on the other side.
Slovenian: Bikonveksna ovalna tableta svetlo rdeče barve, z vtisnjeno oznako „IU‟ na eni strani in „NVR‟ na drugi.
English: Haemoglobin decreased, haematocrit decreased
Slovenian: znižana vrednost hemoglobina, znižana vrednost hematokrita redki:
English: - if you have diabetes mellitus or impaired kidney function and you are treated with either of the following classes of medicines used to treat high blood pressure: an “angiotensin converting enzyme inhibitor” such as enalapril, lisinopril, ramipril etc.
Slovenian: Morda vam bo moral zdravnik spremeniti odmerke ali svetovati druge previdnostne ukrepe ali pa oboje, če jemljete katero od naslednjih zdravil: - zdravila, ki vam povečajo količino kalija v krvi, med njimi so diuretiki, ki varčujejo s kalijem, in nadomestki kalija; - furosemid, to je zdravilo, ki sodi v skupino zdravil imenovano diuretiki ali tablete za odvajanje vode, zaradi katerih se poveča količina urina, ki nastaja v telesu; - zdravilo iz katere od naslednjih skupin zdravil za zdravljenje visokega krvnega tlaka: “zaviralci encima angiotenzinske konvertaze” kot so enalapril, lizinopril, ramipril in podobno,
English: Arthralgia has been reported in post-marketing experience.
Slovenian: Na podlagi izkušenj po prihodu zdravila na trg so poročali o artralgiji.
English: POSSIBLE SIDE EFFECTS
Slovenian: MOŢNI NEŢELENI UČINKI
English: Sprimeo 150 mg film-coated tablets Aliskiren
Slovenian: Sprimeo 150 mg filmsko obloţene tablete aliskiren
English: or an “angiotensin 2 receptor blocker” such as valsartan, telmisartan, irbesartan etc. - ketoconazole, a medicine used to treat fungal infections.
Slovenian: “zaviralci angiotenzinskih receptorjev 2”, kot so valsartan, telmisartan, irbesartan in podobno; - ketokonazol, to je zdravilo za zdravljenje glivičnih okužb; - verapamil, zdravilo za zniževanje visokega krvnega tlaka, uravnavanje srčnega ritma ali za zdravljenje angine pektoris; - določene vrste zdravil proti bolečinam z imenom nesteroidna protivnetna zdravila.
English: Sprimeo 300 mg film-coated tablets Aliskiren
Slovenian: Sprimeo 300 mg filmsko obloţene tablete aliskiren
English: The combination of aliskiren with ARBs or ACEIs is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) and is not recommended in other patients (see sections 4.3, 4.4 and 5.1).
Slovenian: Pri bolnikih s sladkorno boleznijo ali okvaro ledvic (GFR < 60 ml/min/1,73 m2) je sočasna uporaba aliskirena in zaviralcev angiotenzinskih receptorjev II ali zaviralcev ACE kontraindicirana, pri drugih bolnikih pa ni priporočena (glejte poglavja 4.3, 4.4 in 5.1).
English: Acute renal failure, reversible upon discontinuation of treatment, has been reported in at-risk patients receiving aliskiren in post-marketing experience.
Slovenian: Na podlagi izkušenj po prihodu zdravila na trg so pri bolnikih s povečanim tveganjem, ki so jemali aliskiren, opisovali akutno ledvično odpoved, ki je bila reverzibilna po prekinitvi zdravljenja.
English: INTERMEDIATE CARTON OF MULTIPACKS (WITHOUT BLUE BOX) CONTAINING PCTFE/PVC BLISTERS
Slovenian: VMESNA ŠKATLA V SKUPNEM PAKIRANJU, KI VSEBUJE PCTFE/PVC PRETISNE OMOTE (BREZ PODATKOV ZA “BLUE BOX”)
English: Renal artery stenosis
Slovenian: Stenoza ledvične arterije
English: FOLDING BOX FOR UNIT PACK CONTAINING PA/ALU/PVC BLISTERS
Slovenian: ŠKATLA ZA POSAMIČNO PAKIRANJE, KI VSEBUJE PA/ALU/PVC PRETISNE OMOTE
English: Sprimeo is not recommended in patients with severe renal impairment (GFR < 30 ml/min/1.73 m2).
Slovenian: Pri bolnikih s hudo okvaro ledvic (GFR < 30 ml/min/1,73 m2) uporaba zdravila Sprimeo ni priporočena.
English: INTERMEDIATE CARTON OF MULTIPACKS (WITHOUT BLUE BOX) CONTAINING PA/ALU/PVC BLISTERS
Slovenian: VMESNA ŠKATLA V SKUPNEM PAKIRANJU, KI VSEBUJE PA/ALU/PVC PRETISNE OMOTE (BREZ PODATKOV ZA “BLUE BOX”)
English: The concomitant use of aliskiren with ARBs or ACEIs is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.2, 4.4, 4.5 and 5.1).
Slovenian: Pri bolnikih s sladkorno boleznijo ali okvaro ledvic (GFR < 60 ml/min/1,73 m2) je kontraindicirana sočasna uporaba aliskirena in zaviralcev angiotenzinskih receptorjev II ali zaviralcev ACE (glejte poglavja 4.2, 4.4, 4.5 in 5.1).
English: LIST OF EXCIPIENTS
Slovenian: SEZNAM POMOŢNIH SNOVI
English: What Sprimeo contains - The active substance is aliskiren (as hemifumarate) 150 mg. - The other ingredients are crospovidone, hypromellose, magnesium stearate, macrogol,
Slovenian: Kaj vsebuje zdravilo Sprimeo - Zdravilna učinkovina je aliskiren (v obliki hemifumarata) 150 mg. - Pomožne snovi so: krospovidon, hipromeloza, magnezijev stearat, makrogol, mikrokristalna celuloza, povidon, brezvodni koloidni silicijev dioksid, smukec, titanov dioksid (E 171), črni železov oksid (E 172), rdeči železov oksid (E 172).
English: België/Belgique/Belgien Novartis Pharma N.V. Tél/Tel: +32 2 246 16 11
Slovenian: België/Belgique/Belgien Novartis Pharma N.V.
English: OUTER CARTON OF MULTIPACKS (INCLUDING BLUE BOX) CONTAINING PA/ALU/PVC BLISTERS
Slovenian: ZUNANJA ŠKATLA SKUPNEGA PAKIRANJA, KI VSEBUJE PA/ALU/PVC PRETISNE OMOTE (VKLJUČENI PODATKI ZA “BLUE BOX”)
English: What Sprimeo contains - The active substance is aliskiren (as hemifumarate) 300 mg. - The other ingredients are crospovidone, hypromellose, magnesium stearate, macrogol,
Slovenian: Kaj vsebuje zdravilo Sprimeo - Zdravilna učinkovina je aliskiren (v obliki hemifumarata) 300 mg. - Pomožne snovi so: krospovidon, hipromeloza, magnezijev stearat, makrogol, mikrokristalna celuloza, povidon, brezvodni koloidni silicijev dioksid, smukec, titanov dioksid (E 171), črni železov oksid (E 172), rdeči železov oksid (E 172).
English: OUTER CARTON OF MULTIPACKS (INCLUDING BLUE BOX) CONTAINING PCTFE/PVC BLISTERS
Slovenian: ZUNANJA ŠKATLA SKUPNEGA PAKIRANJA, KI VSEBUJE PCTFE/PVC PRETISNE OMOTE (VKLJUČENI PODATKI ZA “BLUE BOX”)
English: Pharmacovigilance system
Slovenian: FARMACEVTSKI PODATKI
English: Not applicable
Slovenian: Uporabno do
English: Rare: Musculoskeletal and connective tissue disorders Common: Renal and urinary disorders Uncommon: General disorders and administration site conditions Uncommon: Investigations Common:
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti: Bolezni sečil občasni:
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING
Slovenian: Izgled zdravila Sprimeo in vsebina pakiranja
English: In hypertensive patients, once-daily administration of Sprimeo at doses of 150 mg and 300 mg provided dose-dependent reductions in both systolic and diastolic blood pressure that were maintained over the entire 24-hour dose interval (maintaining benefit in the early morning) with a mean peak to trough ratio for diastolic response of up to 98% for the 300 mg dose.
Slovenian: Znižanje krvnega tlaka je bilo odvisno od velikosti odmerka in se je ohranilo skozi celoten 24-urni interval odmerjanja (ohranjena koristnost učinka v zgodnjih jutranjih urah).
English: As for other agents acting on the renin-angiotensin system, caution should be exercised when aliskiren is given in the presence of conditions pre-disposing to kidney dysfunction such as hypovolaemia (eg.
Slovenian: Kot pri uporabi drugih zdravil, ki delujejo na sistem renin-angiotenzin, je potreba previdnost pri uporabi aliskirena pri bolnikih z drugimi boleznimi, zaradi katerih so bolj nagnjeni k slabšemu delovanju ledvic, kot so hipovolemija (na primer zaradi izgube krvi, hude ali dolgotrajne diareje, dolgotrajnega bruhanja in podobno), bolezni srca, jeter, sladkorna bolezen ali bolezen ledvic.
English: HOW TO STORE SPRIMEO
Slovenian: SHRANJEVANJE ZDRAVILA SPRIMEO
English: Invented name
Slovenian: (Izmišljeno) ime
English: Date of first authorisation: 15 March 2010 Date of latest renewal: 16 December 2014
Slovenian: Datum prve odobritve: 15. marec 2010 Datum zadnjega podaljšanja: 16. december 2014
English: Your body can also make too much sugar.
Slovenian: Tudi telo lahko proizvaja preveč sladkorja.
English: Do not take a double dose of this medicine.
Slovenian: Ne vzemite dvojnega odmerka tega zdravila.
English: A double dose should not be taken on the same day.
Slovenian: V istem dnevu ne sme vzeti dvojnega odmerka.
English: Based on a Cox model stratified by region.
Slovenian: Na podlagi Coxovega modela, stratificiranega po regiji.
English: Poznańska 12 05-850 Ożarów Mazowiecki Poland
Slovenian: Poznańska 12 05-850 Ożarów Mazowiecki Poljska
English: The relevance of these findings for humans is unknown.
Slovenian: Pomen teh ugotovitev za človeka ni znan.
English: This can lead to serious medical problems like heart disease, kidney disease, blindness, and amputation.
Slovenian: To lahko povzroči resne zdravstvene težave, kot so bolezni srca, bolezni ledvic, slepota ter amputacije.
English: You can take this medicine with or without food and drink.
Slovenian: To zdravilo lahko jemljete s hrano in pijačo ali brez.
English: What is type 2 diabetes?
Slovenian: Kaj je sladkorna bolezen tipa 2?
English: Secondary Outcome
Slovenian: Sekundarni izid
English: Onset of these reactions occurred within the first 3 months after initiation of treatment, with some reports occurring after the first dose.
Slovenian: Te reakcije so nastopile v prvih 3 mesecih po pričetku zdravljenja, v nekaterih primerih pa že po prvem odmerku.
English: Rare: reduced number of platelets
Slovenian: Redki: zmanjšano število krvnih ploščic
English: However, when driving or using machines, it should be taken into account that dizziness and somnolence have been reported.
Slovenian: Vendar pa je treba pri vožnji ali upravljanju strojev upoštevati, da so poročali o omotici in zaspanosti.
English: Diet and exercise can help your body use its blood sugar better.
Slovenian: Dieta in telesna aktivnost pomagata pri boljši izrabi krvnega sladkorja.
English: Common: flu
Slovenian: Pogosti: gripa
English: Because of the high safety margins, these findings do not suggest a relevant risk for human reproduction.
Slovenian: Zaradi visoke meje varnosti te ugotovitve ne kažejo na relevantno tveganje za sposobnost razmnoževanja pri ljudeh.
English: Frequencies are defined as: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000) and not known (cannot be estimated from the available data).
Slovenian: Pogostnost je definirana kot: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000) in neznana pogostnost (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti).
English: STOP taking Ristaben and contact a doctor immediately if you notice any of the following serious side effects:
Slovenian: Zdravilo Ristaben takoj PRENEHAJTE jemati in se posvetujte z zdravnikom, če opazite katerega koli od naslednjih resnih neželenih učinkov:
English: You should not stop taking this medicine without talking to your doctor first.
Slovenian: Zdravila ne smete prenehati jemati, ne da bi se prej posvetovali z zdravnikom.
English: The renal clearance was approximately 350 ml/min.
Slovenian: Ledvični očistek je bil približno 350 ml/min.
English: Uncommon: dry mouth
Slovenian: Občasni: suha usta
English: Do not take Ristaben - if you are allergic to sitagliptin or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Ristaben - če ste alergični na sitagliptin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: 2031 BN Haarlem The Netherlands
Slovenian: 2031 BN Haarlem Nizozemska
English: There was no difference in the incidence of severe hypoglycaemia.
Slovenian: Razlike v pojavnosti hude hipoglikemije ni bilo.
English: What you need to know before you take Ristaben
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Ristaben
English: Common: swelling of the hands or legs
Slovenian: Pogosti: otekanje dlani in nog
English: What Ristaben is and what it is used for
Slovenian: Kaj je zdravilo Ristaben in za kaj ga uporabljamo
English: The mean dose of metformin was approximately 1,900 mg per day.
Slovenian: Srednji odmerek metformina je bil približno 1.900 mg na dan.
English: For composite endpoints, the p-values correspond to a test of non-inferiority seeking to show that the hazard ratio is less than 1.3.
Slovenian: Za sestavljene opazovane dogodke ustrezajo vrednosti p testiranju neinferiornosti z namenom dokaza, da je razmerje ogroženosti manjše od 1,3.
English: Your doctor may prescribe this medicine alone or with certain other medicines that lower blood sugar.
Slovenian: Zdravnik vam lahko predpiše to zdravilo samo ali skupaj z določenimi drugimi zdravili za zniževanje krvnega sladkorja.
English: Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
Slovenian: Zato ni pričakovati pomembnih interakcij z drugimi zaviralci p-glikoproteina.
English: In particular, tell your doctor if you are taking digoxin (a medicine used to treat irregular heart beat and other heart problems).
Slovenian: Obvestite zdravnika zlasti, če jemljete digoksin (zdravilo za zdravljenje nepravilnega bitja srca in drugih težav s srcem).
English: No dose adjustment of digoxin is recommended.
Slovenian: Prilagoditve odmerka digoksina ne priporočamo.
English: Use of DPP-4 inhibitors has been associated with a risk of developing acute pancreatitis.
Slovenian: Uporaba inhibitorjev DPP-4 je povezana s tveganjem za razvoj akutnega pankreatitisa.
English: Because increases of this magnitude are not clinically relevant, dosage adjustment in these patients is not necessary.
Slovenian: Ker zvečanja takšnega obsega niso klinično pomembna, pri teh bolnikih prilagoditev odmerka ni potrebna.
English: Children and adolescents below 18 years should not use this medicine.
Slovenian: Otroci in mladostniki do 18. leta starosti tega zdravila ne smejo jemati.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 (see section 4.4 and 4.8).
Slovenian: Preobčutljivost na učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1 (glejte poglavji 4.4 in 4.8).
English: When this happens, sugar (glucose) builds up in the blood.
Slovenian: V takšnih primerih se sladkor (glukoza) kopiči v krvi.
English: The fraction of sitagliptin reversibly bound to plasma proteins is low (38 %).
Slovenian: Delež sitagliptina, reverzibilno vezanega na plazemske beljakovine, je majhen (38 %).
English: There are no adequate data from the use of sitagliptin in pregnant women.
Slovenian: Ni zadostnih podatkov o uporabi sitagliptina pri nosečnicah.
English: In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy if required.
Slovenian: V primeru prevelikega odmerjanja so smiselni običajni podporni ukrepi, npr. odstranitev neabsorbiranega zdravila iz prebavil, uvedba kliničnega nadzora (vključno s spremljanjem elektrokardiograma) in po potrebi uvedba podpornega zdravljenja.
English: Your doctor may ask you to stop Ristaben.
Slovenian: Zdravnik vam bo morda naročil, da prenehate z jemanjem zdravila Ristaben.
English: If you have kidney problems, your doctor may prescribe lower doses (such as 25 mg or 50 mg).
Slovenian: Če imate težave z ledvicami, vam zdravnik lahko predpiše manjše odmerke zdravila (npr. 25 mg ali 50 mg).
English: The safety and efficacy of sitagliptin in children and adolescents under 18 years of age have not yet been established.
Slovenian: Varnost in učinkovitost sitagliptina pri otrocih in mladostnikih, mlajših od 18 let, nista bili dokazani.
English: Your doctor may prescribe a medicine to treat your allergic reaction and a different medicine for your diabetes.
Slovenian: Zdravnik vam lahko predpiše zdravilo za zdravljenje alergijske reakcije ter drugo zdravilo za sladkorno bolezen.
English: Patients with an eGFR < 30 mL/min/1.73 m2 were not to be enrolled in the study.
Slovenian: Bolniki z eGFR < 30 ml/min/1,73 m niso smeli biti vključeni v študijo.
English: Ristaben should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
Slovenian: Zdravila Ristaben se ne sme uporabljati pri bolnikih s sladkorno boleznijo tipa 1 ali za zdravljenje diabetične ketoacidoze.
English: The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis.
Slovenian: Inkretini so del endokrinega sistema, ki sodeluje pri fiziološkem uravnavanju homeostaze glukoze.
English: You should not take this medicine during pregnancy.
Slovenian: Med nosečnostjo tega zdravila ne smete jemati.
English: Approximately 79 % of sitagliptin is excreted unchanged in the urine.
Slovenian: Približno 79 % sitagliptina se izloči z urinom v nespremenjeni obliki.
English: Do not throw away medicines via wastewater or household waste.
Slovenian: Zdravila ne smete odvreči v odpadne vode ali med gospodinjske odpadke.