FrancophonIA/ELRC3.0 huggingface dataset:
English: As with other medicinal products acting on the renin-angiotensin-aldosterone system, telmisartan may provoke hyperkalaemia (see section 4.4).
Croatian: Poput ostalih lijekova koji djeluju na sustav renin-angiotenzin-aldosteron, telmisartan može izazvati hiperkalijemiju (vidjeti dio 4.4).
English: The risk is particularly high in combination with potassium sparing-diuretics, and when combined with salt substitutes containing potassium.
Croatian: Rizik je osobito visok u kombinaciji s diureticima koji štede kalij i u kombinaciji s nadomjescima soli koje sadrže kalij.
English: SPECIAL PRECAUTIONS FOR DISPOSAL OF UNUSED MEDICINAL PRODUCTS OR WASTE MATERIALS DERIVED FROM SUCH MEDICINAL PRODUCTS, IF APPROPRIATE
Croatian: POSEBNE MJERE ZA UKLANJANJE NEISKORIŠTENOG LIJEKA ILI OTPADNIH
English: Elderly patients No dose adjustment is necessary for elderly patients.
Croatian: Nije potrebno prilagođavati dozu u starijih bolesnika.
English: The safety profile of telmisartan in patients treated for the reduction of cardiovascular morbidity was consistent with that obtained in hypertensive patients.
Croatian: Profil sigurnosti telmisartana u bolesnika liječenih radi smanjenja kardiovaskularnog morbiditeta bio je u skladu s onim u bolesnika s hipertenzijom.
English: In case of surgery or anaesthesia, you should tell your doctor that you are taking Telmisartan Teva.
Croatian: U slučaju kirurškog zahvata ili anestezije, trebate obavijestiti svog liječnika da uzimate Telmisartan Teva.
English: Because no information is available regarding the use of Telmisartan Teva during breast-feeding, Telmisartan Teva is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
Croatian: Budući da ne postoje dostupni podaci o primjeni Telmisartana Teva tijekom dojenja, primjena Telmisartana Teva se ne preporučuje i prednost se daje drugim lijekovima s bolje utvrđenim sigurnosnim profilima tijekom dojenja, osobito tijekom razdoblja dojenja novorođenčeta ili nedonoščeta.
English: • Amifostine (a protective medicine during radiotherapy for cancer treatment)
Croatian: • Baklofen (mišićni relaksans) • Amifostin (lijek koji se koristi tijekom radioterapije pri liječenju raka)
English: Telmisartan selectively binds the AT1 receptor.
Croatian: Telmisartan se selektivno veže na AT1 receptor.
English: In human, an 80 mg dose of telmisartan almost completely inhibits the angiotensin II evoked blood pressure increase.
Croatian: U ljudi, doza od 80 mg telmisartana gotovo u potpunosti inhibira porast krvnog tlaka izazvanog angiotenzinom II.
English: The overall incidence of adverse reactions reported with telmisartan was usually comparable to placebo (41.4% vs 43.9 %) in controlled trials in patients treated for hypertension.
Croatian: Ukupna incidencija nuspojava zabilježenih s telmisartanom bila je uobičajeno usporediva s placebom (41,4 % u odnosu na 43,9 %) u kontroliranim ispitivanjima u bolesnika liječenih zbog hipertenzije.
English: Telmisartan does not inhibit human plasma renin or block ion channels.
Croatian: Telmisartan ne inhibira renin u ljudskoj plazmi niti blokira ionske kanale.
English: As with any antihypertensive agent, excessive reduction of blood pressure in patients with ischaemic cardiopathy or ischaemic cardiovascular disease could result in a myocardial infarction or stroke.
Croatian: Kao i kod drugih antihipertenzivnih lijekova, prekomjerno snižavanje krvnog tlaka u bolesnika s ishemijskom kardiopatijom ili ishemijskom kardiovaskularnom bolešću može rezultirati infarktom miokarda ili moždanim udarom.
English: - if you have severe liver problems such as cholestasis or biliary obstruction (problems with the drainage of the bile from the liver and gall bladder) or any other severe liver disease.
Croatian: Ako imate teške probleme s jetrom kao što su kolestaza ili bilijarna opstrukcija (problemi s drenažom žuči iz jetre i žučnog mjehura) ili neku drugu tešku bolest jetre.
English: However, lower plasma concentrations were observed in patients with renal insufficiency undergoing dialysis.
Croatian: Međutim, niže koncentracije u plazmi uočene su u bolesnika s insuficijencijom bubrega koji su podvrgnuti dijalizi.
English: The adverse reactions listed below have been accumulated from controlled clinical trials in patients treated for hypertension and from post-marketing reports.
Croatian: Dolje navedene nuspojave prikupljene su iz kontroliranih kliničkih ispitivanja u bolesnika liječenih zbog hipertenzije i iz podataka prikupljenih nakon stavljanja lijeka u promet.
English: This applies especially to the medicines listed below taken at the same time with Telmisartan Teva.
Croatian: Ovo se osobito odnosi na lijekove koji su navedeni u nastavku, a uzimaju se istovremeno s Telmisartanom Teva:
English: CV mortality and all cause mortality were numerically higher with the combination.
Croatian: CV (kardiovaskularni) mortalitet i opći mortalitet u ovoj su kombinaciji bili brojčano veći.
English: Most cases of hepatic function abnormal / liver disorder from post-marketing experience occurred in Japanese patients.
Croatian: Većina slučajeva abnormalne funkcije jetre/poremećaja rada jetre nakon stavljanja lijeka u promet, pojavila se u bolesnika u Japanu.
English: Therefore it is not expected to potentiate bradykinin-mediated adverse effects.
Croatian: Stoga se ne očekuje potenciranje nuspojava posredovanih bradikininom.
English: Telmisartan does not exhibit any partial agonist activity at the AT1 receptor.
Croatian: Telmisartan ne pokazuje nikakvo parcijalno agonističko djelovanje na AT1 receptor.
English: Blood creatinine increased
Croatian: Povišeni kreatinin u krvi
English: Bradycardia
Croatian: Bradikardija
English: Other possible side effects of telmisartan:
Croatian: Druge moguće nuspojave telmisartana:
English: Management depends on the time since ingestion and the severity of the symptoms.
Croatian: Zbrinjavanje ovisi o vremenu proteklom od unosa lijeka i težini simptoma.
English: Tablet
Croatian: Tableta.
English: If you forget to take Telmisartan Teva
Croatian: Ako ste zaboravili uzeti Telmisartan Teva
English: • Diuretics (‘water tablets'), especially if taken in high doses together with Telmisartan Teva, may lead to excessive loss of body water and low blood pressure (hypotension).
Croatian: • Diuretici ('tablete za izmokravanje'), osobito ako se uzimaju visoke doze zajedno s Telmisartanom Teva, mogu dovesti do prekomjernog gubitka vode u tijelu te niskog krvnog tlaka (hipotenzija).
English: The incidence of dry cough was significantly lower in patients treated with telmisartan than in those given angiotensin converting enzyme inhibitors in clinical trials directly comparing the two antihypertensive treatments.
Croatian: Incidencija suhog kašlja bila je znatno niža u bolesnika liječenih telmisartanom nego u onih koji su primali inhibitore angiotenzin konvertirajućeg enzima u kliničkim ispitivanjima koja su izravno uspoređivala dva antihipertenzivna liječenja.
English: In both species, increased plasma renin activity and hypertrophy/hyperplasia of the renal juxtaglomerular cells were observed.
Croatian: U obje vrste uočeni su povećano djelovanje renina u plazmi i hipertrofija/hiperplazija jukstaglomerularnih stanica bubrega.
English: As observed for angiotensin converting enzyme inhibitors, telmisartan and the other angiotensin II receptor antagonists are apparently less effective in lowering blood pressure in black people than in non-blacks, possibly because of higher prevalence of low-renin states in the black hypertensive population.
Croatian: Kao što je uočeno za inhibitore angiotenzin konvertirajućeg enzima, telmisartan i drugi antagonisti receptora angiotenzina II su manje učinkoviti u snižavanju krvnog tlaka u osoba crne rase nego u osoba koje nisu crne rase, možda zbog veće prevalencije stanja sa sniženim vrijednostima renina u populaciji crne rase s hipertenzijom.
English: Abdominal pain, diarrhoea, dyspepsia, flatulence, vomiting
Croatian: Bol u abdomenu, proljev, dispepsija, flatulencija, povraćanje
English: Telmisartan Teva is also used to reduce cardiovascular events (i.e. heart attack or stroke) in adults who are at risk because they have a reduced or blocked blood supply to the heart or legs, or have had a stroke or have high risk diabetes.
Croatian: Telmisartan Teva se također primjenjuje za smanjivanje kardiovaskularnih događaja (tj. srčanog udara ili moždanog udara) u rizičnih odraslih osoba koji imaju smanjenu ili prekinutu opskrbu krvlju srca ili nogu, ili su imali moždani udar, ili imaju šećernu bolest s visokim rizikom za oštećenje organa.
English: When initiating, adjusting, and discontinuing telmisartan, monitor digoxin levels in order to maintain levels within the therapeutic range.
Croatian: Prilikom početka, prilagodbe i prekida liječenja, potrebno je pratiti vrijednosti digoksina radi održavanja vrijednosti unutar terapijskog raspona.
English: Close monitoring of serum potassium in at risk patients is recommended (see section 4.5).
Croatian: Preporučuje se pažljivo pratiti kalij u serumu rizičnih bolesnika (vidjeti dio 4.5).
English: Telmisartan is metabolised by conjugation to the glucuronide of the parent compound.
Croatian: Telmisartan se metabolizira konjugacijom na glukuronid osnovnog spoja.
English: Táncsics Mihály út 82 Hungary (Headquarters: 4042 Debrecen, Pallagi út 13)
Croatian: Mađarska (Administrativno sjedište: 4042 Debrecen, Pallagi út 13)
English: Pharmacotherapeutic group: Angiotensin II Antagonists, plain, ATC Code: C09CA07.
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: Antagonisti angiotenzina II, čisti, ATK oznaka: C09CA07.
English: Hypoglycaemia (in diabetic patients)
Croatian: Hipoglikemija (u bolesnika sa šećernom bolešću)
English: In dogs, renal tubular dilation and atrophy were observed.
Croatian: U pasa su uočene renalna tubularna dilatacija i atrofija.
English: Telmisartan Teva is not to be given to patients with cholestasis, biliary obstructive disorders or severe hepatic impairment (see section 4.3) since telmisartan is mostly eliminated with the bile.
Croatian: Telmisartan Teva se ne smije davati bolesnicima s kolestazom, bilijarnom opstrukcijom ili teškim oštećenjem jetrene funkcije (vidjeti dio 4.3), s obzirom da se telmisartan uglavnom eliminira putem žuči.
English: Some patients may already benefit at a daily dose of 20 mg.
Croatian: Pojedini bolesnici mogu imati pozitivan učinak već pri dnevnoj dozi od 20 mg.
English: When telmisartan was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed.
Croatian: Kada je telmisartan bio istodobno primjenjivan s digoksinom, primijećena su povećanja medijana vršnih koncentracija digoksina u plazmi (49%) i koncentracija na kraju dozirnog intervala (20%).
English: Influenza-like illness
Croatian: Bolest nalik gripi
English: TRANSCEND randomized ACE-I intolerant patients with otherwise similar inclusion criteria as ONTARGET to telmisartan 80 mg (n=2954) or placebo (n=2972), both given on top of standard care.
Croatian: Bolesnici s netolerancijom na ACE-I randomizirani u TRANSCEND ispitivanju, s inače sličnim kriterijima uključivosti kao u ONTARGET ispitivanju, randomizirani su na telmisartan 80 mg (n=2954) ili placebo (n=2972), oboje davani povrh standardnog liječenja.
English: Telmisartan Teva may be less effective in lowering the blood pressure in black patients.
Croatian: Telmisartan Teva može biti manje učinkovita u snižavanju krvnog tlaka u bolesnika crne rase.
English: Aluminium-Aluminium blisters : pack size of 30 tablets
Croatian: Aluminij-Aluminij blister: veličine pakovanja od 30 tableta
English: In these patients hypoglycaemia may occur under telmisartan treatment.
Croatian: U ovih bolesnika hipoglikemija se može pojaviti kod liječenja telmisartanom.
English: This adverse reaction was reported as common in patients with controlled blood pressure who were treated with telmisartan for the reduction of cardiovascular morbidity on top of standard care.
Croatian: Ova nuspojava zabilježena je kao česta u bolesnika s kontroliranim krvnim tlakom koji su liječeni telmisartanom radi smanjenja kardiovaskularnog morbiditeta uz standardnu skrb.
English: A), poloxamers, meglumine, povidone (PVP K-30), sorbitol (E420), magnesium stearate
Croatian: poloksameri, meglumin, povidon (PVP K-30), sorbitol (E420) i magnezijev stearat.
English: - if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Croatian: - Ako imate šećernu bolest ili oštećenu bubrežnu funkciju i liječite se lijekom za snižavanje krvnog tlaka koji sadrži aliskiren.
English: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to
Croatian: Nuspojave su poredane po kategorijama učestalosti prema sljedećem pravilu: vrlo često (≥1/10), često (≥1/100 do <1/10), manje često (≥1/1000 do <1/100), rijetko (≥1/10 000 do
English: The mean absolute bioavailability for telmisartan is about 50 %.
Croatian: Srednja vrijednost apsolutne bioraspoloživost telmisartana je oko 50 %.
English: Telmisartan Teva is also provided in aluminium-aluminium blister packs of 30 tablets.
Croatian: Telmisartan Teva je također dostupan u aluminij-aluminij blisteru u pakovanju od 30 tableta.
English: In patients with mild to moderate and severe renal impairment, doubling of plasma concentrations was observed.
Croatian: U bolesnika s blagim do umjerenim i teškim oštećenjem funkcije bubrega, uočeno je udvostručavanje koncentracija u plazmi.
English: Telmisartan is an orally active and specific angiotensin II receptor (type AT1) antagonist.
Croatian: Telmisartan je oralno aktivan i specifičan antagonist receptora angiotenzina II (tip AT1).
English: Angioedema (also with fatal outcome), eczema, erythema, urticaria, drug eruption, toxic skin eruption
Croatian: Angioedem (također sa smrtnim ishodom), ekcem, eritem, urtikarija, osip od lijeka, toksični osip kože
English: Infants whose mothers have taken angiotensin II receptor antagonists should be closely observed for hypotension (see sections 4.3 and 4.4).
Croatian: Dojenčad čije su majke uzimale antagoniste receptora angiotenzina II moraju se pažljivo pratiti radi hipotenzije (vidjeti dijelove 4.3 i 4.4).
English: The safety of long term treatment of telmisartan in children and adolescents was not evaluated.
Croatian: Sigurnost dugotrajnog liječenja telmisartanom kod djece i adolescenata nisu ocjenjivane.
English: Treatment of essential hypertension
Croatian: Liječenje esencijalne hipertenzije
English: Telmisartan tablets are for once-daily oral administration and should be taken with liquid, with or without food.
Croatian: Telmisartan tablete primjenjuju se peroralno jednom dnevno i trebaju se uzimati s tekućinom, sa ili bez hrane.
English: Telmisartan Teva may increase the blood pressure lowering effect of other medicines used to treat high blood pressure.
Croatian: Telmisartan Teva može povećati učinak snižavanja krvnog tlaka drugih lijekova koji se primjenjuju u liječenju visokog krvnog tlaka.
English: When telmisartan is taken with food, the reduction in the area under the plasma concentration-time curve (AUC0-∞) of telmisartan varies from approximately 6 % (40 mg dose) to approximately 19 % (160 mg dose).
Croatian: Kada se telmisartan uzima s hranom, smanjenje površine ispod krivulje koncentracije telmisartana u plazmi-vrijeme (AUC0-∞) varira od oko 6 % (doza 40 mg)
English: Suggested measures include induction of emesis and / or gastric lavage.
Croatian: Predložene mjere uključuju indukciju povraćanja i/ili lavažu želuca.
English: In patients with mild to moderate hepatic impairment, the posology should not exceed 40 mg once daily (see section 4.4).
Croatian: U bolesnika s blagim do umjerenim oštećenjem jetrene funkcije doza ne smije prelaziti 40 mg jednom dnevno (vidjeti dio 4.4).
English: 4.1 Therapeutic indications
Croatian: 4.1 Terapijske indikacije Hipertenzija
English: • if you are taking any of the following medicines used to treat high blood pressure: - an ACE-inhibitor (for example enalapril, lisinopril, ramipril), in particular if you have diabetesrelated kidney problems.
Croatian: • ako uzimate bilo koji od lijekova navedenih u nastavku, koji se koriste za liječenje visokog krvnog tlaka: - ACE inhibitor (primjerice enalapril, lisinopril, ramipril), osobito ako imate bubrežne tegobe povezane sa šećernom bolešću.
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN
Croatian: 6. POSEBNO UPOZORENJE DA LIJEK TREBA ČUVATI IZVAN POGLEDA
English: The pharmacokinetics of two doses of telmisartan were assessed as a secondary objective in hypertensive patients (n = 57) aged 6 to < 18 years after taking telmisartan 1 mg/kg or 2 mg/kg over a four-week treatment period.
Croatian: Farmakokinetika dviju doza telmisartana ocjenjivana je kao sekundarni cilj kod hipertenzivnih bolesnika (n = 57) u dobi 6 do < 18 godina starosti nakon uzimanja telmisartana 1 mg/kg ili 2 mg/kg tijekom četverotjednog razdoblja liječenja.
English: Intravascular hypovolaemia
Croatian: Intravaskularna hipovolemija
English: • Digoxin.
Croatian: • Digoksin
English: Do not take Telmisartan Teva - if you are allergic to telmisartan or any other ingredients of this medicine (listed in section 6).
Croatian: Ako ste alergični na telmisartan ili neke druge sastojke ovog lijeka (navedene u dijelu 6).
English: The all-cause mortality rate was 11.6 % and 11.8 % among telmisartan and ramipril treated patients, respectively.
Croatian: Stopa općeg mortaliteta iznosila je 11,6 % u bolesnika liječenih telmisartanom odnosno 11,8 % u bolesnika liječenih ramiprilom.
English: Renovascular hypertension
Croatian: Renovaskularna hipertenzija
English: The recommended dose is 80 mg once daily.
Croatian: Preporučena doza je 80 mg jedanput na dan.
English: Common side effects (may affect up to 1 in 10 people): Low blood pressure (hypotension) in users treated for reduction of cardiovascular events.
Croatian: Česte nuspojave (mogu se javiti u manje od 1 na 10 osoba): Nizak krvni tlak (hipotenzija) u bolesnika liječenih zbog smanjivanja kardiovaskularnih događaja.
English: Potassium sparing diuretics e.g. spironolactone, eplerenone, triamterene, or amiloride, potassium supplements, or potassium-containing salt substitutes may lead to a significant increase in serum potassium.
Croatian: Diuretici koji štede kalij npr. spirinolakton, eplerenon, triamteren ili amilorid, dodaci kalija ili nadomjesci soli koji sadrže kalij mogu dovesti do značajnog porasta kalija u serumu.
English: Cough and angioedema were less frequently reported in patients treated with telmisartan than in patients treated with ramipril, whereas hypotension was more frequently reported with telmisartan.
Croatian: Kašalj i angioedem rjeđe su zabilježeni u bolesnika liječenih telmisartanom nego u bolesnika liječenih ramiprilom, dok je hipotenzija češće zabilježena s telmisartanom.
English: See also information under the heading “Do not take Telmisartan Teva”.
Croatian: Vidjeti također informacije pod naslovom “Nemojte uzimati Telmisartan Teva ”
English: When Telmisartan Teva is used in patients with impaired renal function, periodic monitoring of potassium and creatinine serum levels is recommended.
Croatian: Kada se Telmisartan Teva primjenjuje u bolesnika s poremećenom funkcijom bubrega, preporučuje se povremeno pratiti vrijednosti kalija i kreatinina u serumu.
English: The blood pressure lowering effects of two doses of telmisartan were assessed in 76 hypertensive, largely overweight patients aged 6 to < 18 years (body weight ≥ 20 kg and ≤ 120 kg, mean 74.6 kg), after taking telmisartan 1 mg/kg (n = 29 treated) or 2 mg/kg (n = 31 treated) over a four-week treatment period.
Croatian: Učinci snižavanja krvnog tlaka dviju doza telmisartana ocjenjivani su na 76 hipertenzivnih bolesnika suvelike pretjeranom težinom u dobi 6 do < 18 godina (tjelesna težina ≥ 20 kg i ≤ 120 kg, prosjek 74,6 kg), nakon uzimanja telmisartana 1 mg/kg (n = 29 liječenih) ili 2 mg/kg (n = 31 liječenih) tijekom četverotjednog razdoblja liječenja.
English: After adjustment for age group effects mean SBP changes from baseline (primary objective) were -14.5 (1.7) mm Hg in the telmisartan 2 mg/kg group, -9.7 (1.7) mm Hg in the telmisartan 1 mg/kg group, and -6.0 (2.4) in the placebo group.
Croatian: Nakon prilagodbe dobnih učinaka skupine prosječna promjena SKT-a u odnosu na početnu vrijednost (primarni cilj) bila je -14.5 (1.7) mm Hg u skupini na 2 mg/kg telmisartana, -9,7 (1,7) mm Hg u skupini na 1 mg/kg telmisartana, te -6,0 (2,4) u skupini na placebu.
English: • Antidepressants
Croatian: • Antidepresivi.
English: Telmisartan Teva belongs to a class of medicines known as angiotensin-II receptor antagonists.
Croatian: Telmisartan Teva pripada skupini lijekova poznatih kao antagonisti receptora angiotenzina II.
English: When driving vehicles or operating machinery it should be taken into account that dizziness or drowsiness may occasionally occur when taking antihypertensive therapy such as Telmisartan Teva.
Croatian: Prilikom upravljanja vozilima ili strojevima, povremeno može doći do pojave omaglice ili pospanosti kada se uzima antihipertenzivna terapija poput Telmisartana Teva.
English: It allows continued monitoring of the benefit/risk balance of the medicinal product.
Croatian: Time se omogućuje kontinuirano praćenja omjera koristi i rizika lijeka.
English: The antihypertensive efficacy of telmisartan is comparable to that of agents representative of other classes of antihypertensive medicinal products (demonstrated in clinical trials comparing telmisartan to amlodipine, atenolol, enalapril, hydrochlorothiazide, and lisinopril).
Croatian: Antihipertenzivna djelotvornost telmisartana usporediva je s onom od tvari koje pripadaju drugim skupinama antihipertenziva (prema kliničkim ispitivanjima usporedbe telmisartana s amlodipinom, atenololom, enalaprilom, hidroklorotiazidom i lizinoprilom).
English: Telmisartan Teva should be used only with caution in patients with mild to moderate hepatic impairment.
Croatian: Telmisartan Teva se treba primjenjivati isključivo s oprezom u bolesnika s blagim do umjerenim oštećenjem jetrene funkcije.
English: The listing also takes into account serious adverse reactions and adverse reactions leading to discontinuation reported in three clinical long-term studies including 21,642 patients treated with telmisartan for the reduction of cardiovascular morbidity for up to six years.
Croatian: Popis također uzima u obzir teške nuspojave i nuspojave koje dovode do prekida liječenja, zabilježene u tri dugotrajna klinička ispitivanja koja su uključivala 21 642 bolesnika liječena telmisartanom radi smanjenja kardiovaskularnog morbiditeta, u trajanju do 6 godina.
English: Visual disturbance
Croatian: Poremećaj vida
English: The use of medicinal products that affect the renin-angiotensin-aldosterone system may cause hyperkalaemia.
Croatian: Hiperkalijemija Primjena lijekova koji utječu na sustav renin-angiotenzin-aldosteron može izazvati hiperkalijemiju.
English: Telmisartan displaces angiotensin II with very high affinity from its binding site at the AT1 receptor subtype, which is responsible for the known actions of angiotensin II.
Croatian: Telmisartan s vrlo visokim afinitetom izmješta angiotenzin II s mjesta vezivanja na AT1 podtipu receptora, koji je odgovoran za poznato djelovanje angiotenzina II.
English: In preclinical safety studies, doses producing exposure comparable to that in the clinical therapeutic range caused reduced red cell parameters (erythrocytes, haemoglobin, haematocrit), changes in renal haemodynamics (increased blood urea nitrogen and creatinine), as well as increased serum potassium in normotensive animals.
Croatian: U pretkliničkim ispitivanjima sigurnosti doze čija ekspozicija je usporediva s onom u kliničkom terapijskom rasponu izazvale su smanjenje parametara crvenih stanica (eritrociti, hemoglobin, hematokrit), promjene u hemodinamici bubrega (povišene vrijednosti dušika iz ureje i kreatinina u krvi), kao i povišeni kalij u serumu normotenzivnih životinja.