FrancophonIA/ELRC3.0 huggingface dataset:
English: In RA study V, the improvement in the HAQ disability index and the physical component of the SF 36 showed greater improvement (p < 0.001) for adalimumab/methotrexate combination therapy versus methotrexate monotherapy and adalimumab monotherapy at week 52, which was maintained through week 104.
Danish: I RA-studie V var forbedringen i HAQ funktionsevneindeks og den fysiske komponent fra SF 36 større (p<0,001) for adalimumab/methotrexat-kombinationsterapi end for methotrexat-monoterapi og adalimumab-monoterapi efter 52 uger.
English: Kromeya therapy should not be continued in patients failing to respond within this time period.
Danish: Fortsat behandling med Kromeya anbefales ikke til patienter, der ikke responderer inden for denne tidsperiode.
English: PASI 75 and PGA of clear or minimal response rates in these patients were 74.7% and 59.0%, respectively, after an additional 108 weeks of open-label therapy (total of 160 weeks).
Danish: PASI 75- og PGA clear/minimal responsrater hos disse patienter var henholdvis 74,7 % og 59, 0 % efter yderligere 108 ugers åben behandling (i alt 160 uger).
English: Step 7 Throw away your Pre-filled pen
Danish: Trin 7 Kassér din pen
English: For patients who stayed on their randomised therapy, the mean (±SD) adalimumab trough concentrations at week 52 were 9.5±5.6 µg/mL for the Standard Dose group and 3.5±2.2 µg/mL for the Low Dose group.
Danish: Hos patienter, som blev på deres randomiserede behandling, var den gennemsnitlige dalkoncentration (±SD) af adalimumab 9,5±5,6 g/ml for standard-dosis-gruppen og 3,5±2,2 g/ml for lav-dois-gruppen ved uge 52.
English: Of 207 patients who were randomised to adalimumab 40mg every other week, 114 patients continued on adalimumab 40 mg every other week for 5 years.
Danish: Ud af 207 patienter, som blev randomiseret til adalimumab 40 mg hver anden uge, fortsatte 114 patienter på adalimumab 40 mg hver anden uge i 5 år.
English: Sustained response
Danish: Vedligeholdt respons
English: Warning: Do not use the pre-filled pen if the liquid contains particles, or is cloudy or if it is colored, or has flakes in it or shows any sign of damage.
Danish: Advarsel: Du må ikke bruge den fyldte pen, hvis væsken indeholder partikler eller flager, er uklar eller misfarvet eller viser tegn på skade.
English: Kromeya 40 mg/0.8 mL
Danish: INFORMATION I BRAILLE-SKRIFT Kromeya 40 mg/0,8 ml
English: Of 342 subjects originally randomised to adalimumab monotherapy or adalimumab/methotrexate combination therapy who entered the open-label extension study, 171 subjects completed 10 years of adalimumab treatment.
Danish: Ud af 342 patienter som startede i det åbne forlængelsesstudie og blev randomiseret til adalimumab monoterapi eller adalimumab/methotrexat kombinationsterapi, afsluttede 171 patienter 10 års behandling med adalimumab.
English: Table 8 ACR responses in RA study V (percent of patients)
Danish: Tabel 8 ACR-respons i RA-studie V (Procentdel af patienter)
English: Kromeya is used to treat moderate to severe plaque psoriasis in adults.
Danish: Kromeya bruges til at behandle moderat til alvorlig plaque-psoriasis hos voksne.
English: A rapid decrease in CRP levels was also observed in patients with polyarticular juvenile idiopathic arthritis, Crohn's disease and ulcerative colitis after treatment with adalimumab.
Danish: Efter behandling med adalimumab blev også observeret et hurtigt fald i CRP-niveau hos patienter med polyartikulær juvenil idiopatisk artrit, Crohns sygdom og colitis ulcerosa.
English: The efficacy of adalimumab was assessed in a randomised, double-blind, controlled study of 114 paediatric patients from 4 years of age with severe chronic plaque psoriasis (as defined by a Physician's Global Assessment (PGA) ≥ 4 or > 20% BSA involvement or > 10% BSA involvement with very thick lesions or Psoriasis Area and Severity Index (PASI) ≥ 20 or ≥ 10 with clinically relevant facial, genital, or hand/ foot involvement) who were inadequately controlled with topical therapy and heliotherapy or phototherapy.
Danish: Adalimumabs virkning er undersøgt i et randomiseret, dobbeltblindet kontrolleret studie med 114 pædiatriske patienter fra 4 år med svær kronisk plaque-psoriasis (defineret ved PGA (physician global assessment) ≥ 4 eller > 20% BSA (body surface area)-involvering eller > 10% BSA-involvering med meget tykke læsioner eller PASI (psoriasis area and severity index) ≥ 20 eller ≥ 10 med klinisk relevante manifestioner i ansigt, på kønsorganer eller hånd/fod), som ikke havde opnået tilstrækkelig kontrol med topikal behandling og helioterapi eller lysbehandling.
English: • Children are not allowed to inject themselves and injection must be done by a trained adult.
Danish: • Børn må ikke indgive injektionen selv.
English: Among those, 86 patients (75.4%) had ACR 20 responses; 72 patients (63.2%) had ACR 50 responses; and 41 patients (36%) had ACR 70 responses.
Danish: Blandt disse havde 86 patienter (75,4%) ACR 20-respons, 72 patienter (63,2%) ACR 50-respons og 41 patienter (36%) ACR 70-respons.
English: You should record the date when the pen is first removed from refrigerator, and the date after which it should be discarded.
Danish: Du skal registrere den dato, hvor pennen først tages ud af køleskabet, og den dato efter hvilken, den skal kasseres.
English: Results from both studies demonstrated statistically significant reduction of the risk of treatment failure in patients treated with adalimumab versus patients receiving placebo (See Table 27).
Danish: Resultaterne i begge studier viste en statistisk signifikant reduktion i risikoen for behandlingssvigt hos patienter behandlet med adalimumab versus patienter, som fik placebo (se tabel 27 ).
English: In the open-label period of the study, PASI 75 and PGA clear or minimal responses were maintained for up to an additional 52 weeks with no new safety findings.
Danish: PASI 75- og PGA clear eller minimal respons blev vedligeholdt i op til yderligere 52 uger uden nye sikkerhedsfund i den åbne del af studiet.
English: Results from both studies demonstrated statistically significant reduction of the risk of treatment failure in patients treated with adalimumab versus patients receiving placebo (See Table 22).
Danish: Resultaterne i begge studier viste en statistisk signifikant reduktion i risikoen for behandlingssvigt hos patienter behandlet med adalimumab versus patienter, som fik placebo (se tabel 22).
English: Excipients: sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, mannitol, sodium chloride, citric acid monohydrate, sodium citrate, polysorbate 80, sodium hydroxide and water for injections.
Danish: Hjælpestoffer: natriumdihydrogenphosphatdihydrat, dinatriumphosphatdihydrat, mannitol, natriumchlorid, citronsyremonohydrat, natriumcitrat, polysorbat 80, natriumhydroxid og vand til injektionsvæsker.
English: • If your child has an infection, including long-term or localised infection (for example, leg ulcer) consult your doctor before starting Kromeya.
Danish: • Hvis dit barn har en infektion, herunder langvarig eller lokaliseret infektion (f.eks. bensår), skal du kontakte din læge, før du begynder at bruge Kromeya.
English: - The other ingredients are sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, mannitol, sodium chloride, citric acid monohydrate, sodium citrate, polysorbate 80, sodium hydroxide and water for injections.
Danish: Øvrige indholdsstoffer: Natriumdihydrogenphosphatdihydrat, dinatriumphosphatdihydrat, mannitol, natriumchlorid, citronsyremonohydrat, natriumcitrat, polysorbat 80, natriumhydroxid og vand til injektionsvæsker.
English: Among those, 64 patients (79.0%) had ACR 20 responses; 56 patients (69.1%) had ACR 50 responses; and 43 patients (53.1%) had ACR 70 responses.
Danish: Blandt disse havde 64 patienter (79,0%) ACR 20-respons, 56 patienter (69,1%) ACR 50respons og 43 patienter (53,1%) ACR 70-respons.
English: Adalimumab/methotrexate patients demonstrated significantly less radiographic progression than patients receiving methotrexate alone at 6 and 12 months (see Table 9).
Danish: Der blev observeret en significant mindre radiografisk progression hos adalimumab-/methotrexat- patienter end hos patienter som alene fik methotrexat efter 6 måneder og 12 måneder (se Tabel 9).
English: Kromeya may have a minor influence on the ability to drive, cycle or use machines.
Danish: Kromeya kan påvirke evnen til at føre motorkøretøj, cykle eller betjene maskiner i mindre grad.
English: Efficacy outcomes
Danish: Effekt-resultater
English: 6.6 The needle is now covered and is safe.
Danish: 6.6 Kanylen er nu tildækket og sikret, og du kan kassere den i affaldsbeholderen til skarpe genstande.
English: Do not use this medicine after the expiry date which is stated on the label/carton after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på etiketten/pakningen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: 1.5 Caution: Do not pick up the syringe by the plunger or the needle cap.
Danish: Figur B 1.5 Forsigtig: Tag ikke fat om injektionssprøjten ved stemplet eller kanylehætten.
English: Psoriasis study III (REACH) compared the efficacy and safety of adalimumab versus placebo in 72 patients with moderate to severe chronic plaque psoriasis and hand and/or foot psoriasis.
Danish: Psoriasis-studie III (REACH) sammenlignede adalimumabs virkning og sikkerhed versus placebo hos 72 patienter med moderat til svær kronisk plaque-psoriasis og psoriasis på hænder og/eller fødder.
English: Median time to disease flare
Danish: Mediantid til opblussen af sygdom
English: Step 6 Give Injection
Danish: Trin 6 Giv injektionen
English: The rate (95% confidence interval) of nonmelanoma skin cancers was 8.8 (6.0, 13.0) per 1,000 patient-years among adalimumab-treated patients and 3.2 (1.3, 7.6) per 1,000 patient-years among control patients.
Danish: Hyppigheden (95 % konfidensinterval) af ikke-melanom hudkræft var 8,8 (6,0-13,0) pr. 1.000 patientår blandt adalimumab-behandlede patienter og 3,2 (1,3-7,6) pr. 1.000 patientår blandt kontrolpatienterne.
English: a p Value b
Danish: P Værdi b
English: Adalimumab was assessed in a multicenter, randomised, double-blind clinical trial designed to evaluate the efficacy and safety of induction and maintenance treatment with doses dependent on body weight (< 40 kg or ≥ 40 kg) in 192 paediatric subjects between the ages of 6 and 17 (inclusive) years, with moderate to severe Crohn´s disease (CD) defined as Paediatric Crohn's Disease Activity Index (PCDAI) score > 30.
Danish: Adalimumabs sikkerhed og virkning ved induktions- og vedligeholdelsesbehandling med doser afhængige af legemsvægt (< 40 kg eller ≥ 40 kg) er undersøgt i et multicenter, randomiseret, dobbeltblindet klinisk studie med 192 pædiatriske patienter i alderen 6 til 17 (inklusive) år med moderat til svær Crohns sygdom (CD), defineret som Paediatric Crohn's Disease Activity Index (PCDAI) score > 30.
English: Store in a refrigerator (2°C - 8°C).
Danish: Opbevares i køleskab( 2 - 8°C).
English: 3.2 Check the label to make sure that:
Danish: 3.2 Tjek etiketten for at sikre dig:
English: Step 5 Prepare Injection
Danish: Trin 5 Forbered injektionen
English: In controlled trials of adalimumab (initial doses of 160 mg at week 0 and 80 mg at week 2, followed by 40 mg every week starting at week 4), in patients with hidradenitis suppurativa with a control period duration ranging from 12 to 16 weeks, ALT elevations ≥ 3 x ULN occurred in 0.3% of adalimumab-treated patients and 0.6% of control-treated patients.
Danish: I kontrollerede studier med adalimumab (startdosis på 160 mg i uge 0 og 80 mg i uge 2, efterfulgt af 40 mg hver uge med start i uge 4) hos patienter med hidrosadenitis suppurativa med en kontrolperiode af 12 til 16 ugers varighed, forekom ALAT-stigning ≥ 3 x ULN hos 0,3% af patienterne i adalimumabbehandling og hos 0,6% af patienterne i kontrol-behandling.
English: Instruction For Use
Danish: INSTRUKTIONER VEDRØRENDE ANVENDELSEN
English: If you accidentally inject Kromeya more frequently than you should, call your doctor or pharmacist and explain that you have taken more than required.
Danish: Hvis du ved en fejltagelse injicerer Kromeya hyppigere, end du skal, kontakt lægen eller apotekspersonalet og forklar, at du har taget mere medicin end nødvendigt.
English: Pulmonary embolism1), interstitial lung disease, chronic obstructive pulmonary disease, pneumonitis, pleural effusion
Danish: Lungeemboli1), interstitiel lungesygdom, kronisk obstruktiv lungesygdom, pneumonitis, pleuraeffusion1)
English: Prescribers should exercise caution in considering the use of Kromeya in patients with pre-existing or recent-onset central or peripheral nervous system demyelinating disorders; discontinuation of Kromeya should be considered if any of these disorders develop.
Danish: Lægen bør udvise forsigtighed, når behandling med Kromeya overvejes til patienter med allerede eksisterende eller nyligt opståede demyeliniserende sygdomme i centralnervesystemet eller det perifere, og seponering skal overvejes, hvis nogle af disse sygdomme forværres.
English: Table 15 Ps study II (CHAMPION) efficacy results at 16 weeks
Danish: Tabel 15 Ps-studie II (CHAMPION) Effektresultater ved uge 16
English: At week 16, more patients randomised to adalimmab 0.8 mg/kg had positive efficacy responses (e.g. PASI 75) than those randomised to 0.4 mg/kg eow or MTX.
Danish: Ved uge 16 havde flere af patienterne, som var randomiseret til adalimumab 0,8 mg/kg, positivt respons for effekt (f.eks. PASI 75) end dem, der var randomiseret til 0,4 mg/kg hver anden uge eller methotrexat.
English: • oedema (a build-up of fluid in the body which causes the affected tissue to swell);
Danish: • ødem (væskeophobning i kroppen, som får det påvirkede væv til at hæve op)
English: No ALT elevations ≥ 3 X ULN occurred in the Phase 3 trial of adalimumab in paediatric patients with plaque psoriasis.
Danish: Der forekom ingen ALAT-stigninger ≥ 3 x ULN i fase 3-studier af adalimumab hos pædiatriske patienter med plaque-psoriasis.
English: Warning: Do not recap the pre-filled pen.
Danish: Advarsel: Du må ikke sætte hætten tilbage på den fyldte pen.
English: Following subcutaneous administration of 40 mg of adalimumab every other week in adult nonradiographic axial spondyloarthritis patients, the mean (±SD) trough steady-state concentration at Week 68 was 8.0 ± 4.6 µg/ml.
Danish: Efter subkutan administration af 40 mg adalimumab hver anden uge til voksne non-radiografisk aksial spondylartritis patienter var den gennemsnitlige (±SD) dal-steady state-koncentration ved uge 68 8,0 ± 4,6 g/ml.
English: Mean steady-state trough levels of approximately 7 µg/mL were observed in Crohn's disease patients who received a maintenance dose of 40 mg adalimumab every other week.
Danish: Gennemsnitlige dal-niveauer på omtrent 7 g/ml ved steady state blev set hos patienter med Crohns sygdom, som fik vedligeholdelsesdosis på 40 mg adalimumab hver anden uge.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT
Danish: INDHOLD ANGIVET SOM VÆGT, VOLUMEN ELLER ANTAL DOSER 0,8 ml
English: Psoriasis study IV compared efficacy and safety of adalimumab versus placebo in 217 adult patients with moderate to severe nail psoriasis.
Danish: Psoriasis-studie IV sammenlignede adalimumabs virkning og sikkerhed overfor placebo i 217 voksne patienter med moderat til svær neglepsoriasis.
English: Textured finger pad
Danish: Nupret fingerflade
English: Each box of Kromeya pre-filled syringe comes with two or six syringes.
Danish: Hver æske af Kromeya fyldt injektionssprøjte indeholder to eller seks injektionssprøjter.
English: In controlled and open label adult and paediatric studies with adalimumab, serious infections (including fatal infections, which occurred rarely) have been reported, which include reports of tuberculosis (including miliary and extra-pulmonary locations) and invasive opportunistic infections (e.g. disseminated or extrapulmonary histoplasmosis, blastomycosis, coccidioidomycosis, pneumocystis, candidiasis, aspergillosis and listeriosis).
Danish: I kontrollerede og åbne studier med voksne og pædiatriske patienter med adalimumab blev der rapporteret alvorlige infektioner (herunder dødelige infektioner, som forekom sjældent), inklusive rapporter om tuberkulose (herunder miliærtuberkulose og ekstra-pulmonær tuberkulose) og invasive opportunistiske infektioner (f.eks.dissemineret eller ekstrapulmonal histoplasmose, blastomykose, kokcidioimykose, pneumocytis, candidiasis, aspergillose og listeriose).
English: • The name on the syringe says Kromeya (Figure K).
Danish: • at der står Kromeya på injektionssprøjten (figur K).
English: Kromeya is used to treat rheumatoid arthritis in adults.
Danish: Kromeya bruges til at behandle reumatoid artrit hos voksne.
English: Polyarticular juvenile idiopathic arthritis from 2 years of age
Danish: Polyartikulær juvenil idiopatisk artrit fra 2 år
English: • Kromeya is a pre-filled syringe for single use only.
Danish: • Kromeya hætteglassæt er kun til engangsbrug.
English: Always take the outer carton or the vial of the medicine with you, even if it is empty.
Danish: Tag altid den ydre karton eller hætteglasset fra medicinen med, også selvom de er tom.
English: Mean steady-state trough levels of approximately 8 µg/mL were observed in ulcerative colitis patients who received a maintenance dose of 40 mg adalimumab every other week.
Danish: Der blev observeret gennemsnitlige steady state dal-koncentrationer på omkring 8 µg/ml hos colitis ulcerosa patienter, som fik en vedligeholdelsesdosis på 40 mg adalimumab hver anden uge.
English: Pediatric Uveitis
Danish: Pædiatrisk uveitis
English: • the date
Danish: • dato
English: Talk to your doctor or pharmacist before using Kromeya
Danish: Kontakt lægen eller apotekspersonalet, før du tager Kromeya.
English: Table 10 ACR responses in RA study V (percent of patients)
Danish: Tabel 10 ACR-respons i RA-studie V (Procentdel af patienter)
English: At 10 years, 79 of 207 patients originally treated with 40 mg adalimumab every other week were evaluated radiographically.
Danish: Efter 10 år blev 79 af 207 patienter, som oprindeligt blev behandlet med 40 mg adalimumab hver anden uge, evalueret radiografisk.
English: Paediatric Crohn's disease Age or body weight
Danish: Pædiatrisk Crohns sygdom Alder eller vægt
English: Patients demonstrating a Pediatric ACR 30 response at week 16 were eligible to be randomised into the double blind (DB) phase and received either adalimumab 24 mg/m up to a maximum of 40 mg, or placebo every other week for an additional 32 weeks or until disease flare.
Danish: Patienter, der udviste et pædiatrisk ACR 30-respons ved uge 16, var egnede til randomisering i den dobbeltblindede fase og fik enten adalimumab 24 mg/m2 op til maksimalt 40 mg eller placebo hver anden uge i yderligere 32 uger eller indtil opblussen af sygdommen.
English: For patients who dose escalated from eow to weekly regimen, the mean (±SD) serum concentrations of adalimumab at week 52 were 15.3±11.4 μg/mL (40/20 mg, weekly) and 6.7±3.5 μg/mL (20/10 mg, weekly).
Danish: Hos patienter, hvis dosering øgedes fra hver anden uge til ugentlig, var den gennemsnitlige (±SD) serum-koncentration af adalimumab 15,3±11,4 μg/ml (40/20 mg ugentlig) og 6,7±3,5 μg/ml (20/10 mg ugentlig) ved uge 52.
English: adalimumab/methotrexate patients demonstrated significantly less radiographic progression than patients receiving methotrexate alone at 6 and 12 months (see Table 11).
Danish: Der blev observeret en significant mindre radiografisk progression hos adalimumab-/methotrexat- patienter end hos patienter som alene fik methotrexat efter 6 måneder og 12 måneder (se Tabel 11).
English: Endoscopic studies in intestinal mucosa have shown evidence of mucosal healing in adalimumab treated patients.
Danish: Endoskopiske undersøgelser af tarmslimhinden har vist tegn på heling af slimhinden hos patienter, som blevet behandlet med adalimumab.
English: • axial spondyloarthritis without radiographic evidence of ankylosing spondylitis,
Danish: • Aksial spondyloartritis uden radiografiske tegn på ankyloserende spondylitis,
English: Warning: Do not warm the pre-filled pen any other way, such as in a microwave, hot water, or direct sunlight.
Danish: Advarsel: Du må ikke varme den fyldte pen på andre måder, som f.eks. i mikroovn, varmt vand eller i direkte sollys.
English: ACR 20 Week 12 Week 24
Danish: ACR 20 Uge 12 Uge 24
English: If these medicines do not work well enough, your child will be given Kromeya to treat his/her polyarticular juvenile idiopathic arthritis or enthesitis-related arthritis.
Danish: Hvis dit barn ikke reagerer tilstrækkeligt godt på disse lægemidler, vil dit barn få Kromeya til behandling af hans/hendes polyartikulære juvenile idiopatiske artrit eller entesopatirelateret artrit.
English: • Keep the Kromeya pre-filled pen out of the reach of children.
Danish: • Opbevar Kromeya fyldt pen utilgængeligt for børn.
English: If you accidentally inject a smaller amount of Kromeya liquid, or if you inject Kromeya less frequently than told to by your child's doctor or pharmacist, you should call your child's doctor or pharmacist and tell him/her that your child has taken less.
Danish: Hvis du ved en fejltagelse har injiceret en mindre mængde Kromeya end ordineret, eller hvis du har injiceret mindre hyppigt end forskrevet af lægen eller apotekspersonalet, skal du kontakte lægen eller apotekspersonalet og fortælle ham/hende, at dit barn har fået for lidt.
English: • Store the Kromeya Vial Kit in its original box to protect it from light.
Danish: • Opbevar Kromeya hætteglassæt i den originale æske for at beskytte mod lys.
English: Table 18 Ps Study II (CHAMPION) efficacy results at 16 weeks
Danish: Tabel 18 Ps-studie II (CHAMPION) Effektresultater ved uge 16
English: GI haemorrhage, dyspepsia, gastroesophageal reflux disease, sicca syndrome
Danish: Gastrointestinal blødning, dyspepsi, gastroøsofageal refluks sygdom, Sjøgrens syndrom
English: Do not remove the needle from the skin when the plunger reaches the end.
Danish: Figur R Træk ikke kanylen ud af huden, når stemplet er nået i bund.
English: 1 sterile injection syringe 1 sterile needle 1 vial adaptor 2 alcohol pads
Danish: 1 steril injektionssprøjte 1 steril kanyle 1 hætteglasadapter 2 spritservietter
English: Patients may first be given other disease-modifying medicines, such as methotrexate.
Danish: Du skal først behandles med anden sygdomsdæmpende medicin såsom methotrexat.
English: Warning: Do not warm the kit any other way, such as in a microwave, hot water, or direct sunlight.
Danish: Advarsel: Du må ikke varme sættet på andre måder som f.eks. i mikroovn, varmt vand eller i direkte sollys.
English: 6.7 If there is blood or liquid on the injection site, gently press a clean cotton ball or gauze on the skin for 10 seconds.
Danish: Hvis der er blod eller væske ved injektionsstedet, skal du forsigtigt duppe huden med et stykke vat eller gaze i 10 sekunder.
English: Adalimumab has been studied in rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and psoriatic arthritis patients taking adalimumab as monotherapy and those taking concomitant methotrexate.
Danish: Adalimumab er blevet undersøgt hos patienter med reumatoid artrit, polyartikulær juvenil idiopatiske artrit og psoriasisartrit, der udelukkende blev behandlet med adalimumab, og hos patienter, der også samtidigt tog methotrexat.
English: The safety and efficacy of adalimumab were studied in adult patients with chronic plaque psoriasis (≥ 10% BSA involvement and PASI ≥ 12 or ≥ 10) who were candidates for systemic therapy or phototherapy in randomised, double-blind studies.
Danish: Adalimumabs sikkerhed og virkning blev undersøgt hos voksne patienter med kronisk plaquepsoriasis ( 10% BSA-involverering og PASI  12 eller  10), som var kandidater til systemisk behandling eller lysbehandling i randomiserede, dobbelt-blinde studier.