FrancophonIA/ELRC3.0 huggingface dataset:
English: PACKAGE LEAFLET Profender 15 mg/3 mg modified-release Tablets for Small Dogs Profender 50 mg/10 mg modified-release Tablets for Medium Dogs Profender 150 mg/30 mg modified-release Tablets for Large Dogs
Slovenian: IME ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI Profender 15 mg/3 mg tablete s prirejenim sproščanjem za majhne pse Profender 50 mg/10 mg tablete s prirejenim sproščanjem za srednje velike pse Profender 150 mg/30 mg tablete s prirejenim sproščanjem za velike pse
English: Transient muscular tremors, incoordination and depression were occasionally observed when the veterinary product was administered at overdoses of up to 5 times the recommended dose.
Slovenian: Pri zaužitju 5-kratnega terapevtskega odmerka se je občasno pojavilo prehodno mišično drgetanje, nekoordiniranost gibov in potrtost.
English: STATEMENT OF ACTIVE SUBSTANCES
Slovenian: 6.1 Seznam pomožnih snovi
English: 21.4 mg/ml emodepside, 85.8 mg/ml praziquantel
Slovenian: KOLIČINA UČINKOVIN(E) 21,4 mg/ml emodepsida, 85,8 mg/ml prazikvantela.
English: 2 tablets 4 tablets
Slovenian: VELIKOST PAKIRANJA 4 tablete
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Profender spot-on solution for small cats Outer carton, pack size of 2 (or 4) pipettes
Slovenian: PODATKI NA ZUNANJI OVOJNINI Profender, kožni nanos, raztopina za majhne mačke Škatla z 2 (ali 4) merilnimi kapalkami
English: KVP Pharma + Veterinär Produkte GmbH Projensdorfer Str. 324
Slovenian: Projensdorfer Str. 324
English: The following pack sizes are available: Profender 15 mg/3 mg tablets for small dogs - 2 tablets
Slovenian: Profender 15 mg/3 mg tablete za majhne pse - 2 tableti
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Profender spot-on solution for medium cats Outer carton, pack size of 2 (or 4) pipettes
Slovenian: PODATKI NA ZUNANJI OVOJNINI Profender, kožni nanos, raztopina za srednje velike mačke Škatla z 2 (ali 4) merilnimi kapalkami
English: Puh/Tel: +358 10 4261
Slovenian: FI-20101 Turku/Åbo Puh/Tel: +358 10 4261
English: Profender 30 mg/7.5 mg spot-on solution for small cats
Slovenian: IME ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI Profender 30 mg/ 7.5 mg kožni nanos, raztopina za majhne mačke
English: Salivation, vomiting and neurological signs (tremor) were observed occasionally when the product was administered at up to 10 times the recommended dose in adult cats and up to 5 times the recommended dose in kittens.
Slovenian: Pri nanosu desetkratnega terapevtskega odmerka odraslim mačkam ter petkratnega terapevtskega odmerka mačjim mladičem, se je občasno pojavilo slinjenje, bruhanje ter nevrološki znaki npr. drget.
English: EU/2/05/054/018 2 tablets EU/2/05/054/019 4 tablets
Slovenian: EU/2/05/054/019 za 4 tablete
English: EXP {month/year} Shelf life after first opening the immediate container: 3 months
Slovenian: Rok uporabnosti po prvem odpiranju vsebnika je…….
English: EU/2/05/054/008 12 pipettes EU/2/05/054/009 20 pipettes EU/2/05/054/010 40 pipettes
Slovenian: EU/2/05/054/009 20 merilnih kapalk EU/2/05/054/010 40 merilnih kapalk
English: Bottle label
Slovenian: Mlečna kislina
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Profender spot-on solution for small cats blister
Slovenian: Profender, kožni nanos, raztopina za majhne mačke Pretisni omot
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Profender spot-on solution for medium cats blister
Slovenian: Profender, kožni nanos, raztopina za srednje velike mačke Etiketa na merilni kapalki
English: Profender 60 mg/15 mg spot-on solution for medium cats
Slovenian: IME ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI Profender 60 mg/ 15 mg kožni nanos, raztopina za srednje velike mačke
English: Profender spot-on solution for medium cats (>2.5-5 kg)
Slovenian: IME ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI Profender za mačke (> 2,5 - 5 kg)
English: Renal excretion of metabolites predominates.
Slovenian: Glavni metaboliti so monohidroksicikloheksilni derivati prazikvantela.
English: Salivation, vomiting and trembling were observed occasionally when the product was administered at up to 10 times the recommended dose in adult cats and up to 5 times the recommended dose in kittens.
Slovenian: Pri nanosu desetkratnega terpevtskega odmerka odraslim mačkam ter petkratnega terapevtskega odmerka mačjim mladičem, se je občasno pojavilo slinjenje, bruhanje ter nevrološki znaki npr. drget.
English: Lot: {number}
Slovenian: ŠTEVILKA SERIJE Lot: {številka}
English: 0.35 ml, 0.70 ml and 1.12 ml per pipette Blister packs containing 2, 4, 12, 20, or 40 unit dose pipettes; 0.70 ml pipette only: additional blister pack containing 80 pipettes
Slovenian: Merilne kapalke z 0,35 ml, 0,70 ml in 1,12 ml raztopine za kožni nanos.
English: Pack sizes: Profender 15 mg / 3 mg modified-release Tablets for Small Dogs
Slovenian: IME ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI Profender 15 mg/3 mg tablete s prirejenim sproščanjem za majhne pse
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Profender spot-on solution for large cats blister
Slovenian: Profender, kožni nanos, raztopina za velike mačke Pretisni omot
English: Use within 60 days after first opening.
Slovenian: Uporabite v roku 60 dni po prvem odprtju.
English: The optimal duration of treatment is unknown.
Slovenian: Optimalno trajanje zdravljenja ni znano.
English: • Look out for infections.
Slovenian: • Bodite pozorni na okužbe.
English: • swelling of the face, lips, tongue or throat.
Slovenian: • oteklost obraza, ustnic, jezika ali grla
English: However, severe exacerbations, including fatalities, have been reported.
Slovenian: Vendar pa so poročali tudi o hudih poslabšanjih, vključno s smrtnimi primeri.
English: The clinical implications of this are unknown.
Slovenian: Klinične posledice tega niso znane.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 15 September 2016
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 15. september 2016
English: These symptoms may indicate that your body's improved immune system is fighting infection.
Slovenian: Ti simptomi lahko nakazujejo, da se izboljšani imunski sistem vašega telesa bojuje proti okužbi.
English: Response after addition of emtricitabine is excluded (total of 17 subjects across both studies).
Slovenian: Odziv po dodajanju emtricitabina je izključen (skupaj 17 oseb v obeh študijah).
English: Study 174-0108
Slovenian: Študija 174-0108
English: 2 years Shelf-life after first opening is 60 days.
Slovenian: 2 leti Rok uporabnosti po prvem odprtju je 60 dni.
English: The tablets are suitable for:
Slovenian: Tablete so primerne za:
English: Keep the tablet bottle with you so that you can easily describe what you have taken.
Slovenian: S seboj imejte plastenko tablet, da boste lahko opisali, kaj ste zaužili.
English: Benefit has also been demonstrated based on histological responses in compensated patients.
Slovenian: Korist je bila dokazana tudi na osnovi histoloških odzivov bolnikov s kompenzirano boleznijo.
English: • It is very important to tell your doctor if you are taking other medicines that may damage your kidneys.
Slovenian: • Zelo pomembno je, da svojega zdravnika obvestite, če jemljete druga zdravila, ki bi lahko poškodovala vaše ledvice.
English: Then mix the powder with about 100 ml (half a glass) of water, orange juice or grape juice and drink immediately.
Slovenian: Nato zmešajte prašek s približno 100 ml (pol kozarca) vode, pomarančnega ali grozdnega soka in nemudoma popijte.
English: • Adults: One tablet each day with food (for example, a meal or a snack).
Slovenian: • odrasli: 1 tableta vsak dan s hrano (na primer ob obroku ali prigrizku).
English: Do not store above 30 °C.
Slovenian: Shranjujte pri temperaturi do 30 °C.
English: However, the subject's HBsAg loss was ultimately confirmed at the subsequent visit.
Slovenian: Izguba HBsAg je bila dokončno potrjena ob naslednjem obisku.
English: No studies on the effects on the ability to drive and use machines have been performed.
Slovenian: Študije o vplivu na sposobnost vožnje in upravljanja strojev niso izvedli.
English: This is because the active substance in this medicine passes into human breast milk.
Slovenian: To je zato, ker učinkovina tega zdravila prehaja v materino mleko.
English: • Tell your doctor immediately about new or unusual symptoms after you stop treatment, particularly symptoms you associate with hepatitis B infection.
Slovenian: • Nemudoma obvestite zdravnika o vsakem novem ali nenavadnem simptomu potem, ko ste prenehali z zdravljenjem, še posebej o simptomih, ki jih povezujete z okužbo s hepatitisom B.
English: • At the request of the European Medicines Agency; • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: • na zahtevo Evropske agencije za zdravila; • ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: Tests may also show: • liver problems.
Slovenian: Preiskave lahko kažejo tudi: • težave z jetri
English: These dose interval adjustments have not been confirmed in clinical studies.
Slovenian: Te prilagoditve odmerkov niso bile potrjene s kliničnimi študijami.
English: • Recommended schedule for monitoring renal function considering the presence or absence of additional risk factors for renal impairment
Slovenian: • priporočeni režim za nadzorovanje delovanja ledvic, upoštevajoč prisotnost ali odsotnost dodatnih dejavnikov tveganja za ledvično okvaro;
English: The HIV and HBV adolescent educational brochures should contain the following key messages:
Slovenian: Izobraževalno gradivo o mladostnikih s HIV in HBV morata vsebovati naslednja ključna sporočila:
English: • increased creatinine in your blood,
Slovenian: • povišan kreatinin v krvi
English: Tests may also show: • decreases in phosphate in the blood.
Slovenian: Preiskave lahko kažejo tudi: • zmanjšanje količine fosfata v krvi
English: If you are an adult, your doctor may advise you to take the tablets less often.
Slovenian: Če ste odrasla oseba, vam bo zdravnik morda svetoval, da jemljete tablete manj pogosto.
English: This is to make sure that your medicine is fully effective, and to reduce the risk of developing resistance to the treatment.
Slovenian: Tako boste zagotovili polno učinkovitost vašega zdravila in zmanjšali možnost razvoja odpornosti na zdravljenje.
English: If you have hepatitis B infection, your doctor will carefully consider the best treatment for you.
Slovenian: Če ste okuženi s hepatitisom B, bo vaš zdravnik skrbno razmislil o najboljšem zdravljenju za vas.
English: Your doctor will carefully consider whether to treat you with combinations of tenofovir and didanosine
Slovenian: Vaš zdravnik bo skrbno pretehtal, če vas bo zdravil s kombinacijami tenofovirja in didanozina.
English: If this is unavoidable, your doctor will monitor your kidney function once a week.
Slovenian: Če je to neizogibno, bo zdravnik enkrat tedensko nadzoroval funkcijo vaših ledvic.
English: • deep, rapid breathing,
Slovenian: • globoko, hitro dihanje
English: Staggered administration (12 hours apart) provided similar results.
Slovenian: Pri razporejenem odmerjanju (na 12 ur) so bili rezultati podobni.
English: • If it is less than 12 hours after it is usually taken, take it as soon as you can, and then take your next dose at its regular time.
Slovenian: • Če je minilo manj kot 12 ur od časa, ko ga običajno vzamete, ga vzemite čim prej in nato vzemite naslednji odmerek ob običajnem času.
English: Ethnicity Pharmacokinetics have not been specifically studied in different ethnic groups.
Slovenian: Etnična pripadnost Farmakokinetike niso posebej preučevali pri različnih etničnih skupinah.
English: If Tenofovir disoproxil Zentiva has been prescribed for your child, please note that all the information in this leaflet is addressed to your child (in this case please read “your child” instead of “you”).
Slovenian: Če je bilo zdravilo Dizoproksiltenofovirat Zentiva predpisano za vašega otroka, veljajo vsi podatki v tem navodilu za uporabo za vašega otroka (v tem primeru berite “vaš otrok” namesto “vi”).
English: Tenofovir is also active against HIV-1 subtypes A, C, D, E, F, G, and O and against HIVBaL in primary monocyte/macrophage cells.
Slovenian: Tenofovir je prav tako aktiven proti podtipom HIV-1 A, C, D, E, F, G in O in proti HIVBaL v primarnih monocitih/makrofagih.
English: U Kabelovny 130 102 37 Prague 10 Czech Republic
Slovenian: U Kabelovny 130 102 37 Prague 10 Češka
English: Other suitable formulations should be checked for their availability.
Slovenian: Preveriti je potrebno razpoložljivost drugih primernih pripravkov.
English: In addition, 61% of patients had normal ALT at week 48.
Slovenian: Poleg tega je 61% bolnikov imelo normalne koncentracije ALT v 48. tednu.
English: medicines which are no longer fully effective due to development of resistance, or have caused side effects.
Slovenian: HIV, ki niso več polno učinkovita zaradi nastanka odpornosti ali so povzročala neželene učinke.
English: Each bottle contains a silica gel desiccant that must be kept in the bottle to help protect your tablets.
Slovenian: Vsaka plastenka vsebuje silikagelsko sušilno sredstvo, ki mora ostati v plastenki zaradi zaščite vaših tablet.
English: Serology (%)
Slovenian: Serologija (%)
English: The decision to treat paediatric patients (adolescents) should be based on careful consideration of individual patient needs and with reference to current paediatric treatment guidelines including the value of baseline histological information.
Slovenian: Odločitev za zdravljenje pediatričnih bolnikov (mladostnikov) mora temeljiti na skrbnem upoštevanju individualnih potreb bolnika in upoštevati trenutne smernice za zdravljenje pediatričnih bolnikov, vključno z vrednostjo izhodiščnih histoloških podatkov.
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100) or rare (≥ 1/10,000 to < 1/1,000).
Slovenian: Pogostnosti so definirane kot zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100) ali redki (≥ 1/10.000 do < 1/1.000).
English: No further K65R development was observed up to week 144.
Slovenian: Do 144. tedna niso opazili nobenega nadaljnjega razvoja K65R.
English: Triple therapy with nucleosides/nucleotides
Slovenian: Tritirno zdravljenje z nukleozidi/nukleotidi
English: Histology Histological response (%)b
Slovenian: Histologija Histološki odziv (%)
English: Week
Slovenian: Teden
English: Liver flares are especially serious, and sometimes fatal in patients with decompensated liver disease.
Slovenian: Poslabšanja so posebno resna in včasih smrtno nevarna pri bolnikih z dekompenzirano jetrno boleznijo.
English: A large amount of data on pregnant women (more than 1,000 pregnancy outcomes) indicate no malformations or foetal/neonatal toxicity associated with tenofovir disoproxil.
Slovenian: Veliko število podatkov pri nosečnicah (več kot 1.000 izpostavljenih nosečnosti) ne kaže na malformacije ali feto/neonatalno toksičnost, povezane z dizoproksiltenofoviratom.
English: Moreover, the reversibility of renal toxicity cannot be fully ascertained.
Slovenian: Poleg tega reverzibilnosti toksičnih učinkov na ledvice ni mogoče popolnoma ugotoviti.
English: Non-clinical safety pharmacology studies reveal no special hazard for humans.
Slovenian: Predklinične študije farmakološke varnosti ne kažejo posebnega tveganja za človeka.
English: (using MDRD equation).
Slovenian: na leto (z uporabo enačbe MDRD).
English: • adolescents aged 12 to less than 18 years.
Slovenian: • mladostnike, stare 12 do manj kot 18 let.
English: k One patient in this group became HBsAg negative for the first time at the 240 week visit and was ongoing in the study at the time of the data cut-off.
Slovenian: En bolnik v tej skupini je postal prvič negativen na HBsAg ob obisku v 240. tednu, kar je ostalo ves čas študije do trenutka prvega zbiranja podatkov.
English: You can also pass on HIV or HBV to others, so it is important to take precautions to avoid infecting other people.
Slovenian: Virus HIV ali HBV lahko prenesete tudi na druge, zato je pomembno, da uporabljate zaščitne ukrepe, ki preprečujejo okužbo drugih oseb.
English: • If it is more than 12 hours since you should have taken it, forget about the missed dose.
Slovenian: • Če je minilo več kot 12 ur, odkar naj bi vzeli zdravilo, pozabljenega odmerka ne vzemite.
English: • If you become pregnant, or plan to become pregnant, ask your doctor about the potential benefits and risks of your antiretroviral therapy to you and your child.
Slovenian: • Če zanosite ali načrtujete zanositev, se posvetujte z zdravnikom o možnih koristih in tveganjih vašega protiretrovirusnega zdravljenja za vas in vašega otroka.
English: Renal and bone effects in adult population
Slovenian: Učinki na ledvice in kosti pri odrasli populaciji
English: *Generally, once weekly dosing assuming three haemodialysis sessions per week, each of approximately 4 hours duration or after 12 hours cumulative haemodialysis.
Slovenian: * Na splošno velja: 1 odmerek enkrat tedensko pri predpostavljenih treh hemodializah na teden, vsaka po približno 4 ure ali skupno 12 ur hemodialize.
English: • You must not take Tenofovir disoproxil Zentiva during pregnancy unless specifically discussed with your doctor.
Slovenian: • Zdravila Dizoproksiltenofovirat Zentiva ne smete jemati med nosečnostjo, razen če ste se o tem posebej dogovorili s svojim zdravnikom.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/16/1127/001 30 film-coated tablets EU/1/16/1127/002 90 (3x30) film-coated tablets
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/16/1127/001 30 filmsko obloženih tablet EU/1/16/1127/002 90 (3x30) filmsko obloženih tablet
English: It is not known whether tenofovir can be removed by peritoneal dialysis.
Slovenian: Ni znano, ali se lahko tenofovir odstrani s peritonealno dializo.
English: • If you have taken Tenofovir disoproxil Zentiva during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Slovenian: • Če ste zdravilo Dizoproksiltenofovirat Zentiva jemali med nosečnostjo, vas lahko zdravnik naroči na redne preiskave krvi in druge diagnostične preiskave, da bo spremljal razvoj vašega otroka.
English: Tenofovir can be removed by haemodialysis; the median haemodialysis clearance of tenofovir is 134 ml/min.
Slovenian: Tenofovir se lahko odstrani s hemodializo; vrednost mediane hemodializnega očistka za tenofovir je 134 ml/min.
English: Week 72
Slovenian: 72. teden
English: The Marketing Authorisation Holder (MAH) shall ensure that all physicians who are expected to prescribe/use Tenofovir disoproxil Zentiva in adolescent patients are provided with a physician educational pack containing the Summary of Product Characteristics and an appropriate educational brochure, as detailed below:
Slovenian: Imetnik dovoljenja za promet z zdravilom bo zagotovil, da bodo vsi zdravniki, za katere se pričakuje, da bodo predpisovali/uporabljali zdravilo Dizoproksiltenofovirat Zentiva pri mladostnikih, prejeli izobraževalni paket za zdravnika, ki bo vseboval Povzetek glavnih značilnosti zdravila in primerne izobraževalno gradivo, kot je navedeno v nadaljevanju:
English: Contact your doctor or nearest emergency department for advice.
Slovenian: Posvetujte se z zdravnikom ali poiščite najbližjo urgentno ambulanto.
English: Interaction with didanosine
Slovenian: Medsebojno delovanje z didanozinom
English: Maximum tenofovir concentrations are observed in serum within one hour of dosing in the fasted state and within two hours when taken with food.
Slovenian: Najvišje koncentracije tenofovirja so opazne v serumu znotraj ene ure po zaužitju na tešče in znotraj dveh ur po zaužitju s hrano.
English: All adverse reactions are presented in Table 2.
Slovenian: Vsi neželeni učinki so predstavljeni v preglednici 2.
English: Decreases in BMD of hip were significantly greater in this group until 96 weeks.
Slovenian: Zmanjšanje MGK v kolku je bilo do 96. tedna značilno večje v tej skupini.
English: Study 174-0103 (HBeAg positive)
Slovenian: Študija 174-0103 (pozitivni na HBeAg)
English: Co-administration and risk of renal toxicity The same recommendations apply as in adults (see above).
Slovenian: Sočasna uporaba in tveganje za toksične učinke na ledvice Uporablja se ista priporočila kot pri odraslih (glejte zgoraj).
English: • Talk to your doctor or pharmacist if you have had kidney disease or if tests have shown problems with your kidneys.
Slovenian: • Posvetujte se s svojim zdravnikom ali farmacevtom, če ste kdaj imeli bolezni ledvic ali če so preiskave kazale na težave z ledvicami.
English: The following side effects are uncommon (may affect up to 1 in 100 people): • breakdown of muscle, muscle pain or weakness.
Slovenian: Naslednji neželeni učinki so občasni (prizadenejo lahko do 1 od 100 bolnikov): • razpad mišičnega tkiva, bolečine v mišicah ali mišična oslabelost.
English: The majority of subjects were either genotypes C (43.8%) or D (41.6%) with a lower and similar frequency of genotypes A and B (6.7% each).
Slovenian: Večina bolnikov je bila okužena bodisi z genotipom C (43,8 %) ali D (41,6 %), z manjšo in podobno pogostnostjo genotipov A in B (po 6,7 %).
English: Treatment discontinuation may be considered as follows:
Slovenian: Prekinitev zdravljenja pride v poštev v naslednjih primerih:
English: Study 174-0102 (HBeAg negative)
Slovenian: Študija 174-0102 (negativni na HBeAg)
English: Among them, 3 patients experienced a clinically meaningful decline in estimated GFR which improved after discontinuation of tenofovir disoproxil.
Slovenian: Med njimi so imeli 3 bolniki klinično pomembno zmanjšanje ocenjene GFR, ki se je po prekinitvi uporabe dizoproksiltenofovirata izboljšala.
English: Other medicines and Tenofovir disoproxil Zentiva Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Slovenian: Druga zdravila in zdravilo Dizoproksiltenofovirat Zentiva Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
English: Tolerability failure (permanent discontinuation of study drug due to a treatment emergent AE)
Slovenian: tolerančna napaka (trajna prekinitev zdravljenja s študijskim zdravilom zaradi neželenega učinka, povezanega z zdravljenjem)
English: However, a benefit is expected for the adolescent population based on extrapolation of adult data and comparative pharmacokinetic data (see section 5.2).
Slovenian: Vendar se koristi pričakujejo za populacijo mladostnikov na podlagi ekstrapolacije podatkov pri odraslih in primerljivih podatkov o farmakokinetiki (glejte poglavje
English: These renal transport proteins may be responsible for tubular secretion and in part, renal elimination of tenofovir and cidofovir.
Slovenian: Te transportne beljakovine v ledvicah bi lahko bile odgovorne za tubularno sekrecijo in delno tudi za ledvično izločanje tenofovirja in cidofovirja.
English: With respect to the decision to initiate treatment in paediatric patients, see sections 4.2, 4.4, 4.8 and 5.1.
Slovenian: Glede odločanja o uvedbi zdravljenja pri pediatričnih bolnikih glejte poglavja 4.2, 4.4, 4.8 in 5.1.
English: Following oral administration the terminal half-life of tenofovir is approximately 12 to 18 hours.
Slovenian: Po peroralnem vnosu je končni razpolovni čas tenofovirja približno 12 do 18 ur.
English: However, there was no increased risk of fractures or evidence for clinically relevant bone abnormalities over 144 weeks.
Slovenian: Vendar pa v 144 tednih ni bilo povečanega tveganja za zlome ali znakov klinično pomembnih anomalij na kosteh.