FrancophonIA/ELRC3.0 huggingface dataset:
English: In vitro protein binding of tenofovir to plasma or serum protein was less than 0.7 and 7.2%, respectively, over the tenofovir concentration range 0.01 to 25 µg/mL.
Croatian: In vitro proteinsko vezanje tenofovira na proteine plazme ili seruma bilo je manje od 0,7 odnosno 7,2%, u rasponu koncentracija tenofovira od 0,01 do 25 µg/ml.
English: Your doctor may do blood tests to see if your kidneys are working properly
Croatian: Vam može napraviti krvne pretrage da provjeri rade li bubrezi ispravno.
English: Co-administration of Stribild and sildenafil for the treatment of pulmonary arterial hypertension is contraindicated.
Croatian: Istodobna primjena Stribilda i sildenafila za liječenje plućne arterijske hipertenzije je kontraindicirana.
English: It is especially important to talk to your doctor if you are taking any of the following:
Croatian: Posebno je važno obavijestiti liječnika ako uzimate bilo koji sljedeći lijek:
English: High density polyethylene (HDPE) bottle with a polypropylene child-resistant closure containing 30 film-coated tablets and a silica gel desiccant.
Croatian: Boca od polietilena visoke gustoće (HDPE) s polipropilenskim sigurnosnim zatvaračem za djecu, koja sadrži 30 filmom obloženih tableta i sredstvo za sušenje (silika gel).
English: At week 48, six adolescents in the tenofovir disoproxil group and one adolescent in the placebo group had significant lumbar spine BMD loss (defined as > 4% loss).
Croatian: U 48. tjednu u šest adolescenata iz skupine koja je primala tenofovirdizoproksil i jednog adolescenta iz skupine koja je primala placebo, zabilježen je značajan gubitak BMD-a u lumbalnoj kralježnici (definirano kao gubitak > 4%).
English: The safety and efficacy of Stribild have not been established in patients with significant underlying liver disorders.
Croatian: Sigurnost i djelotvornost primjene Stribilda nije utvrđena u bolesnika s postojećim značajnim poremećajima jetre.
English: Pharmacokinetics of elvitegravir, cobicistat, emtricitabine and tenofovir have not been evaluated in the elderly (over 65 years).
Croatian: Farmakokinetika elvitegravira, kobicistata, emtricitabina i tenofovira nije ispitana u starijih bolesnika (preko 65 godina).
English: • If you have kidney problems, or have had kidney problems, or if tests have shown problems with your kidneys.
Croatian: • Ako imate tegobe s bubrezima, ili ste imali tegobe s bubrezima ili ako su pretrage ukazale na tegobe s bubrezima.
English: No development of resistance to cobicistat can be demonstrated in HIV-1 in vitro due to its lack of antiviral activity.
Croatian: Razvoj rezistencije na kobicistat nije zapažena za HIV-1 in vitro zbog nedostatka njegovog antivirusnog djelovanja.
English: Indigo carmine aluminium lake (E132), macrogol 3350 (E1521), polyvinyl alcohol (partially hydrolysed) (E1203), talc (E553B), titanium dioxide (E171), yellow iron oxide (E172).
Croatian: Bojilo indigo carmine aluminium lake (E132), makrogol 3350 (E1521), poli(vinilni alkohol) (djelomično hidroliziran) (E1203), talk (E553B), titanijev dioksid (E171), žuti željezov oksid (E172)
English: In phenotypic analyses of isolates from patients in the resistance analysis population, 13 patients (31%) had HIV-1 isolates with reduced susceptibility to elvitegravir, 17 patients (40%) had reduced susceptibility to emtricitabine, and 2 patients (5%) had reduced susceptibility to tenofovir.
Croatian: U fenotipskim analizama izolata u bolesnika iz populacije analize rezistencije, 13 bolesnika (31%) imalo je HIV-1 izolate sa smanjenom osjetljivošću na elvitegravir, 17 bolesnika (40%) imalo je smanjenu osjetljivost na emtricitabin i 2 bolesnika (5%) imala su smanjenu osjetljivost na tenofovir.
English: The most frequently reported adverse reactions to Stribild in clinical studies through 48 weeks in virologically-suppressed adult patients were nausea (3% to 5%) and fatigue (6%).
Croatian: Najčešće zabilježene nuspojave Stribilda u kliničkim ispitivanjima tijekom 48 tjedana u odraslih bolesnika kod kojih je virus suprimiran bile su mučnina (3% do 5%) i umor (6%).
English: The pharmacokinetics of emtricitabine have not been studied in subjects with hepatic impairment; however, emtricitabine is not significantly metabolised by liver enzymes, so the impact of liver impairment should be limited.
Croatian: Farmakokinetika emtricitabina nije ispitana u ispitanika s oštećenjem funkcije jetre; međutim emtricitabin se neznatno metabolizira putem enzima jetre, pa bi učinak oštećenja funkcije jetre morao biti ograničen.
English: Interaction not studied with any of the components of Stribild.
Croatian: Interakcija nije ispitana ni s jednom komponentom Stribilda.
English: a Patients were stratified by baseline HIV-1 RNA in both studies.
Croatian: a Bolesnici su bili stratificirani prema početnim vrijednostima HIV-1 RNK u oba ispitivanja.
English: Findings in repeat-dose toxicity studies in rats, dogs and monkeys at exposure levels greater than or equal to clinical exposure levels and with possible relevance to clinical use included kidney and bone changes and a decrease in serum phosphate concentration.
Croatian: Nalazi ispitivanja toksičnosti ponovljenih doza u štakora, pasa i majmuna pri razinama ekspozicije većim ili jednakim kliničkim razinama ekspozicije u ljudi i s mogućom važnošću za kliničku primjenu, uključivali su promjene na bubrezima i kostima i smanjenje koncentracije fosfata u serumu.
English: Emtricitabine and tenofovir are primarily excreted by the kidneys by a combination of glomerular filtration and active tubular secretion.
Croatian: Emtricitabin i tenofovir se primarno izlučuju putem bubrega kombinacijom glomerularne filtracije i aktivne tubularne sekrecije.
English: See also under Co-administration of other medicinal products below.
Croatian: Također vidjeti pod Istodobna primjena drugih lijekova u nastavku.
English: Stribild contains lactose
Croatian: Stribild sadrži laktozu
English: If a patient misses a dose of Stribild by more than 18 hours and it is almost time for the next dose, the patient should not take the missed dose and simply resume the usual dosing schedule.
Croatian: Ako bolesnik propusti uzeti dozu Stribilda u roku duljem od 18 sati i uskoro je vrijeme za sljedeću dozu, bolesnik ne treba uzeti propuštenu dozu nego jednostavno nastaviti uzimati doze prema uobičajenom rasporedu.
English: • breakdown of muscle, muscle pain or weakness
Croatian: • propadanje mišića, bolovi u mišićima ili slabost mišića.
English: In this study, the safety profile of Stribild was similar to that in adults (see section 4.8, Tabulated summary of adverse reactions).
Croatian: U tom ispitivanju sigurnosni profil Stribilda bio je sličan onom u odraslih bolesnika (vidjeti dio 4.8, Tablični prikaz nuspojava).
English: The Marketing Authorisation Holder (MAH) shall ensure that all physicians who are expected to prescribe/use Stribild in adolescent patients are provided with a physician educational pack containing the following:
Croatian: Nositelj odobrenja mora osigurati da svi liječnici od kojih se očekuje propisivanje/primjena lijeka Stribild adolescentima prime edukacijski paket za liječnike sljedećeg sadržaja:
English: If alternatives cannot be used, its use should only take place after medical evaluation and under close monitoring by your doctor for corticosteroid side effects.
Croatian: Ako se ne mogu primjenjivati drugi lijekovi, potrebno je započeti s primjenom tih lijekova tek nakon medicinske procjene i pod pomnim praćenjem liječnika radi eventualnih nuspojava kortikosteroida.
English: Table 5: Changes in pharmacokinetic parameters from the IMPAACT P1026s study for elvitegravir and cobicistat in women receiving cobicistat and elvitegravir-containing regimens during the second and third trimesters of pregnancy compared to paired postpartum data
Croatian: Tablica 5: Promjene farmakokinetičkih parametara u ispitivanju IMPAACT P1026s za elvitegravir i kobicistat u žena koje su primale režime koji sadrže kobicistat i elvitegravir tijekom drugog i trećeg tromjesečja trudnoće u usporedbi s uparenim podacima iz postpartalnog razdoblja
English: When your supply of Stribild starts to run low, get more from your doctor or pharmacist.
Croatian: Kad Vam se smanji zaliha Stribilda, nabavite još lijeka od liječnika ili ljekarnika.
English: The use of Stribild in children below 12 years of age and who weigh less than 35kg has not been studied.
Croatian: Primjena Stribilda u djece mlađe od 12 godina i tjelesne težine manje od 35 kg nije ispitana.
English: • erectile dysfunction medicines, used to treat impotence, such as: sildenafil, tadalafil and vardenafil
Croatian: • lijekove za erektilnu disfunkciju, primjenjuju se za liječenje impotencije, kao što su: sildenafil, tadalafil i vardenafil
English: Studies with emtricitabine
Croatian: Klinička ispitivanja s emtricitabinom
English: Following oral administration of [14C]elvitegravir/ritonavir, 94.8% of the dose was recovered in faeces, consistent with the hepatobiliary elimination of elvitegravir; 6.7% of the administered dose was recovered in urine.
Croatian: Nakon peroralne primjene [14C]elvitegravira/ritonavira, 94,8% doze izolirano je u stolici, što je u skladu s hepatobilijarnom eliminacijom elvitegravira; 6,7% primijenjene doze izolirano je u urinu.
English: In addition to the adverse reactions reported in adults, anaemia (9.5%) and skin discolouration (31.8%) occurred more frequently in clinical trials in paediatric patients than in adults (see section 4.8, Tabulated summary of adverse reactions).
Croatian: Osim nuspojava koje su zabilježene u odraslih bolesnika, anemija (9,5%) i promjena boja kože (31,8%) javljale su se u kliničkim ispitivanjima pedijatrijskih bolesnika češće nego u odraslih bolesnika (vidjeti dio 4.8, Tablični prikaz nuspojava).
English: • antibiotics, used to treat bacterial infections including tuberculosis, containing: rifabutin, clarithromycin or telithromycin
Croatian: • antibiotike, primjenjuju se za liječenje bakterijskih infekcija, uključujući i tuberkulozu, a koji sadržavaju: rifabutin, klaritromicin ili telitromicin
English: HIV-1 isolates with reduced susceptibility to elvitegravir have been selected in cell culture.
Croatian: Izolati virusa HIV-1 sa smanjenom osjetljivošću na elvitegravir izdvojeni su u staničnoj kulturi.
English: If Stribild is used with nephrotoxic medicinal products, renal function should be closely monitored according to the recommended schedule.
Croatian: Ako se Stribild primjenjuje s nefrotoksičnim lijekovima, bubrežnu funkciju se mora pažljivo nadzirati prema preporučenom rasporedu.
English: Clinical monitoring is recommended for patients with ClCr < 90 mL/min.
Croatian: Klinički nadzor preporučuje se za bolesnike s vrijednošću ClCr < 90 ml/min.
English: • and you notice within 18 hours of the time you usually take Stribild, you must take the tablet as soon as possible.
Croatian: • i primijetite to dok je prošlo manje od 18 sati od vremena kad obično uzimate Stribild, tabletu morate uzeti što prije.
English: Following oral administration of [14C]cobicistat, 99% of circulating radioactivity in plasma was unchanged cobicistat.
Croatian: Nakon peroralne primjene pojačanog [14C]kobicistata, 99% cirkulirajuće radioaktivnosti u plazmi bio je nepromijenjeni kobicistat.
English: Resistance to emtricitabine or tenofovir has been seen in vitro and in the HIV-1 from some patients due to the development of the M184V or M184I emtricitabine resistance substitution in reverse transcriptase or the K65R tenofovir resistance substitution in reverse transcriptase.
Croatian: Rezistencija na emtricitabin i tenofovir bila je opažena in vitro i u nekih bolesnika inficiranih virusom HIV-1, zbog razvoja M184V ili M184I supstitucije rezistencije na emtricitabin u reverznoj transkriptazi ili K65R supstitucije rezistencije na tenofovir u reverznoj transkriptazi.
English: Stribild film-coated tablets are green, capsule-shaped tablets, debossed on one side with “GSI” and the number “1” surrounded by a square box on the other side of the tablet.
Croatian: Stribild filmom obložene tablete su zelene tablete u obliku kapsula s utisnutom oznakom „GSI” na jednoj strani i brojem „1” u kvadratiću na drugoj strani tablete.
English: If you are affected while taking Stribild, do not drive and do not use any tools or machines.
Croatian: Ako tijekom uzimanja Stribilda imate takve simptome, nemojte upravljati vozilom niti raditi s alatima ili na strojevima.
English: Three (0.8%) subjects who received ATV/r+FTC/tenofovir disoproxil developed laboratory findings consistent with proximal renal tubular dysfunction leading to discontinuation of ATV/r+FTC/tenofovir disoproxil after Week 96 (see section 4.4).
Croatian: Tri ispitanika (0,8%) koja su primala ATV/r+ FTC/tenofovirdizoproksilimala su laboratorijske nalaze konzistentne s poremećajem funkcije proksimalnih bubrežnih tubula što je dovelo do prekida primanja ATV/r+ FTC/tenofovirdizoproksilnakon 96. tjedna (vidjeti dio 4.4).
English: Among them, 3 patients experienced a clinically meaningful decline in estimated GFR during therapy which improved after discontinuation of tenofovir disoproxil.
Croatian: Među njima su tri bolesnika imala klinički značajan pad procijenjene brzine glomerularne filtracije tijekom terapije, što se poboljšalo nakon prestanka uzimanja tenofovirdizoproksila.
English: Four (0.6%) of the subjects who received Stribild developed laboratory findings consistent with proximal tubulopathy leading to discontinuation of Stribild during the first 48 weeks.
Croatian: Četiri ispitanika (0,6%) koja su primala Stribild imala su laboratorijske nalaze konzistentne s proksimalnom tubulopatijom koja je dovela do prekida primanja Stribilda tijekom prvih 48 tjedana.
English: If concomitant use of Stribild and nephrotoxic agents is unavoidable, renal function must be monitored weekly.
Croatian: Ako se istodobna primjena Stribilda i nefrotoksičnih lijekova ne može izbjeći, funkcija bubrega se mora pratiti svakog tjedna.
English: Other substitutions in integrase that occurred in addition to a primary INSTI resistance substitution each in single cases were H51Y, L68V, G140C, S153A, E157Q, and G163R.
Croatian: Ostale supstitucije u integrazi koje su nastale pored primarne supstitucije rezistencije na INSTI u svakom pojedinačnom slučaju bile su H51Y, L68V, G140C, S153A, E157Q i G163R.
English: However, in case of initiation of Stribild in patients previously taking didanosine or discontinuation of Stribild and change to a regimen including didanosine there could be a short period when measurable plasma levels of didanosine and tenofovir occur.
Croatian: Međutim, u slučaju početka liječenja Stribildom bolesnika koji su prethodno uzimali didanozin ili su prekinuli liječenje Stribildom te prešli na režim liječenja koji je uključivao didanozin, može postojati kratko razdoblje kad je u plazmi moguće izmjeriti razine didanozina i tenofovira.
English: Co-administration with CYP3A-metabolised corticosteroids is not recommended unless the potential benefit to the patient outweighs the risk, in which case patients should be monitored for systemic corticosteroid effects.
Croatian: Ne preporučuje se istodobna primjena s kortikosteroidima koji se metaboliziraju putem CYP3A, osim kada potencijalna korist za bolesnika nadmašuje rizik, a u tom slučaju je bolesnike potrebno pratiti radi eventualnih sustavnih učinaka kortikosteroida.
English: During treatment with Stribild
Croatian: Tijekom liječenja Stribildom
English: Dose modifications are not necessary when rosuvastatin is administered in combination with Stribild.
Croatian: Izmjene doze nisu potrebne kada se rosuvastatin primjenjuje u kombinaciji sa Stribildom.
English: Do not breast-feed during treatment with Stribild.
Croatian: Nemojte dojiti tijekom liječenja Stribildom.
English: Renal function (creatinine clearance and urine glucose and urine protein) should be evaluated prior to treatment initiation, and creatinine clearance, serum phosphate, urine glucose and urine protein should be monitored during treatment as in HIV-1 infected adults (see above).
Croatian: Funkciju bubrega (klirens kreatinina i glukoza i proteini u urinu) potrebno je procijeniti prije početka liječenja, a tijekom liječenja potrebno je pratiti klirens kreatinina, vrijednost fosfata u serumu i glukoze i proteina u urinu kao i u odraslih osoba zaraženih virusom HIV-1 (vidjeti gore).
English: The mean change in estimated glomerular filtration rate (eGFR) by Cockcroft-Gault method after 144 weeks of treatment was -14.0 ± 16.6 mL/min for Stribild, -1.9 ± 17.9 mL/min for EFV/FTC/tenofovir disoproxil, and -9.8 ± 19.4 mL/min for ATV/r+FTC/tenofovir disoproxil.
Croatian: Srednja vrijednost promjene procijenjene brzine glomerularne filtracije (eGFR) Cockcroft-Gaultovom metodom nakon 144 tjedna liječenja bila je -14,0 ± 16,6 ml/min za Stribild, -1,9 ± 17,9 ml/min za EFV/FTC/tenofovirdizoproksili -9,8 ± 19,4 ml/min za ATV/r+FTC/tenofovirdizoproksil.
English: What Stribild is and what it is used for Stribild contains four active substances:
Croatian: Stribild sadrži četiri djelatne tvari:
English: suicidal ideation and suicide attempt (in patients with a pre-existing history of depression or psychiatric illness), depression Nervous system disorders: Very common:
Croatian: suicidalne ideje i pokušaj samoubojstva (u bolesnika s anamnezom depresije ili psihijatrijske bolesti), depresija Poremećaji živčanog sustava:
English: All 48 patients who received at least one dose of Stribild remained suppressed (HIV-1 RNA < 50 copies/mL) through Week 48.
Croatian: U svih 48 bolesnika koji su primili najmanje jednu dozu Stribilda virus je ostao suprimiran (HIV-1 RNK < 50 kopija/ml) tijekom 48 tjedana.
English: Elvitegravir is 98-99% bound to human plasma proteins and binding is independent of drug concentration over the range of 1 ng/mL to 1,600 ng/mL.
Croatian: 98-99% elvitegravira je vezano za proteine u plazmi ljudi, te je vezivanje neovisno o koncentraciji lijeka u rasponu od 1 ng/ml do 1600 ng/ml.
English: Inhibition of CYP3A-mediated metabolism by cobicistat enhances the systemic exposure of CYP3A substrates, such as elvitegravir, where bioavailability is limited and half-life is shortened by CYP3A-dependent metabolism.
Croatian: Inhibicija CYP3A posredovanim metabolizmom putem kobicistata pojačava sistemsku izloženost supstratima CYP3A, kao što je elvitegravir, čija je bioraspoloživost ograničena, a poluvrijeme skraćeno metabolizmom koji ovisi o CYP3A.
English: • Children given emtricitabine very commonly experienced changes in skin colour including darkening of the skin in patches
Croatian: • U djece koja su primala emtricitabin vrlo često su se javljale promjene boje kože uključujući tamne mrlje.
English: If bone abnormalities are suspected then appropriate consultation should be obtained.
Croatian: Ako se posumnja na koštane poremećaje, mora se provesti odgovarajuće savjetovanje.
English: Pharmacokinetics of emtricitabine and tenofovir disoproxil have not been fully evaluated in hepatitis B and/or C virus co-infected patients.
Croatian: Farmakokinetika emtricitabina i tenofovirdizoproksila nije potpuno procijenjena u bolesnika zaraženih virusom hepatitisa B i/ili C.
English: hyperglycaemia1, hypertriglyceridaemia1, decreased appetite
Croatian: hiperglikemija1, hipertrigliceridemija1, smanjeni apetit
English: Disopyramide Flecainide Systemic lidocaine Mexiletine Propafenone
Croatian: Dizopiramid Flekainid Sustavni lidocain Meksiletin Propafenon
English: Hepatitis Cvirus (HCV) antiviral agents Ledipasvir/Sofosbuvir
Croatian: Antivirusni lijekovi za virus hepatitisa C (HCV) Ledipasvir/sofosbuvir
English: PDE-5 inhibitors are primarily metabolised by CYP3A.
Croatian: Inhibitori PDE-5 prvenstveno se metaboliziraju genom CYP3A.
English: • sedatives/hypnotics: orally administered midazolam, triazolam
Croatian: • sedativi/hipnotici: midazolam peroralno primijenjen, triazolam
English: There are currently inadequate data to determine whether co-administration of tenofovir disoproxil and cobicistat is associated with a greater risk of renal adverse reactions compared with regimens that include tenofovir disoproxil without cobicistat.
Croatian: Trenutno ne postoje odgovarajući podaci za određivanje je li istodobna primjena tenofovirdizoproksila i kobicistata povezana s većim rizikom od bubrežnih nuspojava u usporedbi s režimima koji uključuju tenofovirdizoproksil bez kobicistata.
English: Emtricitabine-resistant viruses with the M184V/I substitution were cross-resistant to lamivudine, but retained sensitivity to didanosine, stavudine, tenofovir and zidovudine.
Croatian: Virusi rezistentni na emtricitabin sa supstitucijom M184V/I bili su križno rezistentni na lamivudin, ali su zadržali osjetljivost na didanozin, stavudin, tenofovir i zidovudin.
English: Patients at risk of renal impairment (such as patients with baseline renal risk factors, advanced HIV disease, or patients receiving concomitant nephrotoxic medications) are at increased risk of experiencing incomplete recovery of renal function despite tenofovir disoproxil discontinuation (see section 4.4).
Croatian: Bolesnici s rizikom od oštećenja bubrega (kao što su bolesnici s početnim bubrežnim čimbenicima rizika, uznapredovalom HIV bolešću ili bolesnici koji istodobno primaju nefrotoksične lijekove) pod povećanim su rizikom od nepotpunog oporavka funkcije bubrega usprkos prekidu terapije tenofovirdizoproksilom (vidjeti dio 4.4).
English: The following may be signs of lactic acidosis: deep, rapid breathing tiredness or drowsiness feeling sick (nausea), being sick (vomiting) stomach pain
Croatian: Sljedeći znakovi mogu ukazivati na laktacidozu: - duboko, ubrzano disanje - umor ili omamljenost - mučnina, povraćanje - bolovi u trbuhu.
English: Green, capsule-shaped, film-coated tablet of dimensions 20 mm x 10 mm, debossed on one side with “GSI” and the number “1” surrounded by a square box on the other side.
Croatian: Zelena filmom obložena tableta u obliku kapsule veličine 20 mm x 10 mm, s utisnutom oznakom „GSI” na jednoj strani i brojem „1” u kvadratiću na drugoj strani.
English: It is recommended that Stribild is discontinued in patients with creatinine clearance that falls to < 70 mL/min while on treatment unless it is considered that the potential benefit of this combination of antiretroviral agents for the individual patient outweighs the possible risks of continuing with therapy.
Croatian: Preporučuje se prekinuti liječenje Stribildom u bolesnika s padom klirensa kreatinina na < 70 ml/min tijekom liječenja osim ako se ne smatra da potencijalna korist ove kombinacije retrovirusnih lijekova za pojedine bolesnike nadmašuje moguće rizike od nastavka liječenja.
English: Patients were randomised in a 2:1 ratio to either switch to Stribild or stay on their baseline antiretroviral regimen (SBR) for 48 weeks.
Croatian: Bolesnici su bili randomizirani u omjeru 2:1 kako bi prešli na Stribild ili ostali na početnom antiretrovirusnom režimu (engl. stayed on baseline regimen, SBR) tijekom 48 tjedana.
English: No additional proximal renal tubular dysfunction cases were reported from Week 48 to Week 144.
Croatian: Dodatni slučajevi poremećaja funkcije proksimalnih bubrežnih tubula nisu zabilježeni od 48. do 144. tjedna.
English: The frequency category was estimated from a statistical calculation based on the total number of patients exposed to emtricitabine in randomised controlled clinical studies (n = 1,563) or tenofovir disoproxil in randomised controlled clinical studies and the expanded access program (n = 7,319).
Croatian: Kategorija učestalosti procijenjena je iz statističkog izračuna na temelju ukupnog broja bolesnika izloženih emtricitabinu u randomiziranim kontroliranim kliničkim ispitivanjima (n = 1563) ili tenofovirdizoproksilu u randomiziranim kontroliranim kliničkim ispitivanjima i programu proširenog pristupa liječenju (n = 7319).
English: Renal and bone effects in adults
Croatian: Učinci na funkciju bubrega i kosti u odraslih
English: For elvitegravir, Cmax and AUC increased 22% and 36% with a light meal, while increasing 56% and 91% with a high-fat meal, respectively.
Croatian: Vrijednosti Cmax i AUC za elvitegravir povećale su se 22%, odnosno 36% s laganim obrokom, a s visokomasnim obrokom 56%, odnosno 91%.