FrancophonIA/ELRC3.0 huggingface dataset:
English: Taking Xaluprine could put you at greater risk of: - developing a serious condition called Macrophage Activation Syndrome (excessive activation of white blood cells associated with inflammation), which usually occurs in people who have certain types of arthritis
Croatian: Uzimanje Xaluprinea moglo bi u Vas dovesti do povećanog rizika od: - nastanka teškog stanja koje se naziva sindrom aktivacije makrofaga (prekomjerna aktivacija bijelih stanica povezana s upalom), koje se obično pojavljuje u osoba koje imaju određenu vrstu artritisa
English: Immunisation using a live organism vaccine has the potential to cause infection in immunocompromised hosts.
Croatian: Imunosupresija Imunizacija uporabom živih cjepiva može uzrokovati infekcije u imunokompromitiranih osoba.
English: Additional side effects in children Low blood sugar (hypoglycaemia) - the frequency is unknown.
Croatian: Dodatne nuspojave u djece Niska razina šećera u krvi (hipoglikemija) - učestalost nepoznata.
English: As this medicine contains sucrose, patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Croatian: S obzirom da lijek sadrži saharozu bolesnici s nasljednom intolerancijom fruktoze, malapsorpcijom glukoze-galaktoze ili insuficijencijom saharaza-izomaltaze ne smiju uzimati ovaj lijek.
English: The main route of elimination for 6-mercaptopurine is by metabolism.
Croatian: Glavni put eliminacije 6-merkaptopurina jest metabolizmom.
English: - If you have diarrhoea
Croatian: Ako imate proljev
English: Pull the plunger back to the point on the scale that corresponds to the dose prescribed (figure 5).
Croatian: Povucite klip nazad do oznake koja odgovara propisanoj dozi (slika 5).
English: Safe handling of the suspension
Croatian: Sigurno rukovanje suspenzijom
English: Do not breast-feed while taking Xaluprine.
Croatian: Nemojte dojiti dok uzimate Xaluprine.
English: - Do not take Xaluprine if you are allergic (hypersensitive) to mercaptopurine or any of the other ingredients of Xaluprine (see section 6).
Croatian: - Nemojte uzimati Xaluprine ako se alergični (preosjetljivi) na merkaptopurin ili neki drugi sastojak Xaluprinea (naveden u dijelu 6).
English: Since impaired renal function may result in slower elimination of mercaptopurine and its metabolites and therefore a greater cumulative effect, consideration should be given to reduced starting doses in patients with impaired renal function.
Croatian: Budući da oštećena funkcija bubrega može dovesti do sporije eliminacije merkaptopurina i njegovih metabolita i time do većeg kumulativnog učinka, dolazi u obzir smanjenje početne doze u bolesnika s oštećenom funkcijom bubrega.
English: Uric acid is a natural body chemical, levels of which can rise while taking Xaluprine.
Croatian: Mokraćna kiselina prirodni je tjelesni spoj čije se razine podižu za vrijeme uzimanja Xaluprinea.
English: To decrease the risk of exposure, parents and care givers should wear disposable gloves when handling Xaluprine.
Croatian: Kako bi se smanjio rizik od izloženosti, roditelji i njegovatelji trebaju nositi rukavice za jednokratnu uporabu dok rukuju Xaluprineom.
English: Vaccinations with other live organism vaccines are not recommended in immunocompromised individuals (see section 4.4).
Croatian: Cijepljenje drugim živim cjepivima ne preporučuje se u imunokompromitiranih osoba (vidjeti dio 4.4).
English: Keep the bottle tightly closed to protect the integrity of the product and minimise the risk of accidental spillage.
Croatian: Bočicu čuvajte čvrsto zatvorenu kako bi se zaštitio integritet lijeka i maksimalno smanjio rizik od slučajnog prolijevanja.
English: Talk to your child´s doctor if this happens.
Croatian: U tom slučaju obratite se liječniku svojeg djeteta.
English: Concomitant use with yellow fever vaccine (see section 4.5)
Croatian: Istodobna uporaba s cjepivom protiv žute groznice (vidjeti dio 4.5).
English: Cross-resistance usually exists between 6-mercaptopurine and 6-thioguanine.
Croatian: Ukrižena rezistencija obično postoji između 6-merkaptopurina i 6-tiogvanina.
English: When you are treated with Xaluprine the risk of viral, fungal and bacterial infections is increased and the infections may be more serious.
Croatian: Infekcije Kada se liječite Xaluprineom, povećva se rizik od virusnih, gljivičnih i baketrijskih infekcija, a infekcije mogu biti puno ozbiljnije.
English: Common (affects less than 1 in 10 people) - feeling or being sick (nausea or vomiting) - liver damage - this may show up in blood tests - a drop in red blood cells which may make you tired, weak or breathless (called anaemia) - loss of appetite - diarrhoea - inflammation of the mouth (stomatitis)
Croatian: Često (javljaju se u manje od 1 na 10 osoba) - osjećaj mučnine ili povraćanje - oštećenje jetre - može se pokazati u krvnim pretragama - pad broja crvenih krvnih stanica (eritrocita) zbog čega možete biti umorni, slabi ili osjećati nedostatak zraka (stanje zvano anemija) - gubitak apetita - proljev - upala usta (stomatitis)
English: If you are not sure about how much medicine to draw into the syringe, always ask your doctor or nurse for advice.
Croatian: Ako niste sigurni koliko lijeka uvući u štrcaljku, uvijek pitajte svog liječnika ili medicinsku sestru za savjet.
English: Xaluprine treatment should be supervised by a physician or other healthcare professionals experienced in the management of patients with ALL.
Croatian: Liječenje Xaluprineom treba nadzirati liječnik ili drugi zdravstveni radnici iskusni u liječenju bolesnika s ALL-om.
English: This problem could be exacerbated by coadministration with active substances that inhibit TPMT, such as olsalazine, mesalazine or sulfasalazine.
Croatian: Problem može pogoršati istodobna primjena s djelatnim tvarima koje inhibiraju TPMT poput olsalazina, mesalazina ili sulfalazina.
English: Other xanthine oxidase inhibitors should be avoided (see section 4.5).
Croatian: Druge inhibitore ksantin oksidaze potrebno je izbjegavati (vidjeti dio 4.5).
English: NUDT15-gene mutation
Croatian: Mutacija gena NUDT15
English: It comes in glass bottles of 100 ml capped with a child-resistant closure.
Croatian: Isporučuje se u staklenim bočicama od 100 ml sa zatvaračem sigurnim za djecu.
English: Anyone handling Xaluprine should wash their hands before and after administering a dose.
Croatian: Sigurno rukovanje Svatko tko rukuje lijekom Xaluprine treba oprati ruke prije i nakon primjene doze lijeka.
English: Tell your doctor before starting treatment whether or not you have had chickenpox, shingles or hepatitis B (a liver disease caused by a virus).
Croatian: Obavijestite svog liječnika prije početka liječenja o tome jeste li ili niste imali vodene kozice, herpes zoster ili hepatitis B (bolest jetre uzrokovana virusom).
English: This medicinal product contains aspartame (E951), a source of phenylalanine.
Croatian: Ovaj lijek sadrži aspartam (E951), izvor fenilalanina.
English: Turn the bottle back the right way up and carefully remove the syringe from the adaptor, holding it by the barrel rather than the plunger.
Croatian: Okrenite bočicu na pravu stranu i pažljivo uklonite štrcaljku iz nastavka, držeći je za tijelo, a ne za klip.
English: Accidental ingestion can be lethal for children.
Croatian: Slučajno gutanje može biti smrtonosno za djecu.
English: Pull the plunger of the syringe back so that the medicine is drawn from the bottle into the syringe.
Croatian: Povucite klip štrcaljke unazad tako da povučete lijek iz bočice u štrcaljku.
English: Any unused product or waste material should be disposed of in accordance with local requirements.
Croatian: Neiskorišteni lijek ili otpadni materijal treba zbrinuti u skladu s lokalnim propisima.
English: - Any yellowing of the whites of the eyes or skin (jaundice)
Croatian: Bilo koje žutilo bjeloočnica ili kože (žutica)
English: As there is no known antidote the blood picture should be closely monitored and general supportive measures, together with appropriate blood transfusion, instituted if necessary.
Croatian: Budući da ne postoji antidot, potrebno je pomno provjeravati krvnu sliku te prema potrebi provesti potporno liječenje zajedno s odgovarajućom transfuzijom krvnih pripravaka.
English: When allopurinol and 6-mercaptopurine are administered concomitantly it is essential that only a quarter of the usual dose of 6-mercaptopurine is given.
Croatian: Kad se alopurinol i 6-merkaptopurin primjenjuju istodobno, nužno je primijeniti samo četvrtinu uobičajene doze 6-merkaptopurina.
English: The adverse reactions are displayed by system organ class and frequency: very common (≥1/10), common (≥1/100 to < 1/10), uncommon
Croatian: Nuspojave su navedene prema klasifikaciji organskih sustava i učestalosti: vrlo često (≥1/10), često (≥1/100 i < 1/10), manje često
English: Your doctor or pharmacist will advise you of the correct syringe to use, either the 1 ml (purple syringe) or the 5 ml (white syringe) in order to give the correct dose.
Croatian: Vaš liječnik ili ljekarnik savjetovat će vas o tome koju ćete štrcaljku upotrijebiti, onu od 1 ml (ljubičasta štrcaljka) ili onu od 5 ml (bijela štrcaljka) kako biste primijenili točnu dozu.
English: Secondary leukaemia and myelodysplasia
Croatian: Sekundarna leukemija i mijelodisplazija
English: Repeat the above for each dose as instructed by your doctor or pharmacist.
Croatian: Ponovite prethodno opisani postupak za svako doziranje prema uputama svog liječnika ili ljekarnika.
English: 6-mercaptopurine has been identified in the colostrum and breast-milk of women receiving azathioprine treatment and thus women receiving Xaluprine should not breast-feed.
Croatian: 6-merkaptopurin je nađen u kolostrumu i majčinom mlijeku žena koje primaju azatioprin pa stoga žene koje primaju Xaluprine ne smiju dojiti.
English: There have also been reports of congenital abnormalities and spontaneous abortion following either maternal or paternal exposure.
Croatian: Postoje također i izvješća o kongenitalnim malformacijama i spontanim pobačajima nakon izloženosti majke ili oca.
English: The thioguanine nucleotides are also incorporated into nucleic acids and this contributes to the cytotoxic effects of the active substance.
Croatian: Tiogvaninski nukleotidi također se ugrađuju u nukleinske kiseline, a to pridonosi citotoksičnim učincima djelatne tvari.
English: Carcinogenicity Given its genotoxic potential, 6-mercaptopurine is potentially carcinogenic.
Croatian: S obzirom na svoj genotoksični potencijal 6-merkaptopurin je potencijalno kancerogen.
English: - Your doctor may sometimes change your dose of Xaluprine as a result of these tests.
Croatian: - Liječnik Vam ponekad može promijeniti dozu Xaluprinea na temelju navedenih testova.
English: Sometimes the doctor may change your dose of Xaluprine for example as a result of different tests.
Croatian: Liječnik Vam ponekad može promijeniti dozu Xaluprinea na temelju rezultata različitih testova.
English: In view of its action on cellular deoxyribonucleic acid (DNA) 6-mercaptopurine is potentially carcinogenic and consideration should be given to the theoretical risk of carcinogenesis with this treatment.
Croatian: S obzirom na njegov učinak na staničnu deoksiribonukleinsku kiselinu (DNK) 6-merkaptopurin je potencijalno kancerogen pa je tijekom liječenja potrebno uzeti u obzir teorijski rizik od kancerogeneze.
English: Both men and women should continue to use effective contraception for at least 3 months after stopping treatment.
Croatian: I muškarci i žene trebaju nastaviti primjenjivati djelotvornu metodu zaštite od trudnoće tijekom najmanje 3 mjeseca nakon završetka liječenja.
English: If you stop taking Xaluprine
Croatian: Ako prestanete uzimati Xaluprine
English: Parents and care givers should avoid Xaluprine contact with skin or mucous membrane.
Croatian: Roditelji i njegovatelji trebaju izbjegavati kontakt Xaluprina s kožom ili sluznicama.
English: There are individuals with an inherited deficiency of the TPMT enzyme activity who are very sensitive to the myelosuppresive effect of 6-mercaptopurine and prone to developing rapid bone marrow depression following the initiation of treatment with 6-mercaptopurine.
Croatian: Postoje osobe s naslijeđenim manjkom aktivnosti enzima TPMT koji su vrlo osjetljivi na mijelosupresivni učinak 6-merkaptopurina i skloni brzom razvijanju supresije koštane srži nakon početka liječenja 6-merkaptopurinom.
English: - Do not use this medicine after the expiry date which is stated on the carton and the bottle after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na pakiranju i bočici iza oznake „Rok valjanosti“.
English: Cytotoxic agents may decrease the intestinal absorption of phenytoin.
Croatian: Citotoksični agensi mogu smanjiti crijevnu apsorpciju fenitoina.
English: To assist accurate and consistent dose delivery to the stomach water should be taken after each dose of Xaluprine.
Croatian: Kako bi se omogućila isporuka točne i konzistentne dnevne doze do želuca, nakon svake doze
English: 6-mercaptopurine is metabolised by the polymorphic TPMT enzyme.
Croatian: 6-merkaptopurin se metabolizira putem polimorfnog enzima TPMT.
English: This is usually reversible if 6-mercaptopurine therapy is stopped soon enough but fatal liver damage has occurred.
Croatian: Ona je obično reverzibilna ako se liječenje 6-merkaptopurinom prekine dovoljno rano, ali su zabilježeni i slučajevi smrtonosnog oštećenja funkcije jetre.
English: If Xaluprine comes into contact with skin, eyes or nose, it should be washed immediately and thoroughly with soap and water.
Croatian: Ako Xaluprine dođe u dodir s kožom, očima ili nosom, treba ih odmah temeljito isprati vodom i sapunom.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Nova Laboratories Ireland Limited
Croatian: 11. NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Nova Laboratories Ireland Limited
English: Xaluprine is used for acute lymphoblastic leukaemia (also called acute lymphocytic leukaemia or ALL).
Croatian: Xaluprine se koristi za liječenje akutne limfoblastične leukemije (koju također nazivamo i akutnom limfocitnom leukemijom ili ALL).
English: Approximately 7% of an oral dose is excreted as unchanged 6-mercaptopurine within 12 hours after administration.
Croatian: Približno 7% oralne doze izlučuje se kao nepromijenjeni 6-merkaptopurin unutar
English: Very rare (affects less than 1 in 10,000 people) - a different type of leukaemia to that being treated - ulcers in the intestines
Croatian: Vrlo rijetko (javljaju se u manje od 1 na 10 000 osoba) - leukemija različitog tipa od one koja se liječi - čirevi na crijevima
English: The 6-mecaptopurine oral suspension and tablet are not bioequivalent with respect to peak plasma concentration, and therefore intensified haematological monitoring of the patient is advised on switching formulations (see section 5.2).
Croatian: Oralna suspenzija 6-merkaptopurina i tablete nisu bioekvivalentne s obzirom na vršne koncentracije u plazmi te se stoga savjetuje intenzivno praćenje hematoloških parametara u bolesnika pri zamjeni farmaceutskih oblika lijeka (vidjeti dio 5.2).
English: 6-mercaptopurine causes embryolethality and severe teratogenic effects in the mouse, rat, hamster and rabbit at doses that are non-toxic to the mother.
Croatian: 6-merkaptopurin uzrokuje smrt embrija i teške teratogene učinke na mišu, štakoru, hrčku i kuniću u dozama koje nisu toksične za majku.
English: Transient profound oligospermia has been reported following exposure to 6-mercaptopurine in combination with corticosteroids.
Croatian: Prolazna izrazita oligospermija zabilježena je nakon izloženosti 6-merkaptopurinu u kombinaciji s kortikosteroidima.
English: Substantial dose reductions are generally required for homozygous-TPMT deficiency patients to avoid the development of life threatening bone marrow suppression.
Croatian: Znatne redukcije doze općenito su nužne u bolesnika koji su homozigoti za deficit TPMT-a kako bi se izbjegla životno ugrožavajuća supresije koštane srži.
English: *inflammatory bowel disease (IBD) is an unlicensed indication
Croatian: *upalna bolest crijeva (UBC) nije odobrena indikacija
English: Xanthine oxidase is the main catabolic enzyme and it converts the 6-mercaptopurine into the inactive metabolite, 6-thiouric acid.
Croatian: Ksantin oksidaza je glavni katabolički enzim koji pretvara 6-merkaptopurin u inaktivni metabolit, 6-tiouričnu kiselinu.
English: Your can take your medicine with food or on an empty stomach but the choice of method should be consistent from day to day.
Croatian: Možete uzeti svoj lijek s hranom ili natašte, ali na isti način svaki dan.
English: It is recommended that the healthcare professional advises the patient or carer which syringe to use to ensure that the correct volume is administered.
Croatian: Zdravstvenom djelatniku se preporučuje da savjetuje bolesniku ili njegovom njegovatelju koje štrcaljke koristiti kako bi osigurao primjenu točnog volumena.
English: Since there is a potential for reduced elimination of mercaptopurine, consideration should be given to reduced starting doses in patients with impaired hepatic function.
Croatian: S obzirom na mogućnost smanjene eliminacije merkaptopurina, dolazi u obzir smanjenje početne doze u bolesnika s oštećenom funkcijom jetre.
English: Very common (affects more than 1 in 10 people) - a drop in the number of white blood cells and platelets (may show up in blood tests)
Croatian: Vrlo često (javljaju se više od 1 na 10 osoba) - pad broja bijelih krvnih stanica (leukocita) i trombocita (može se pokazati u krvnim testovima)
English: The larger 5 ml syringe (white), marked 1 ml to 5 ml, is for measuring doses of more than 1 ml.
Croatian: Veća štrcaljka od 5 ml (bijela), označena s 1 ml do 5 ml, služi za mjerenje doza većih od 1 ml.
English: Hepatosplenic T-cell lymphoma has been reported in patients with inflammatory bowel disease* treated with azathioprine (the prodrug to 6-mercaptopurine) or 6-mercaptopurine, either with or without concomitant treatment with anti-TNF alpha antibody.
Croatian: Hepatosplenični T-stanični limfom prijavljen je u bolesnika s upalnom bolesti crijeva* liječenih azatioprinom (predlijek 6-merkaptopurina) ili 6-merkaptopurinom, sa ili bez istodobnog liječenja s anti-TNF alfa antitijelima.
English: Increases in chromosomal aberrations were observed in the peripheral lymphocytes of leukaemic patients, in a renal cell carcinoma patient who received an unstated dose of 6-mercaptopurine and in patients with chronic renal disease treated at doses of 0.4 - 1.0 mg/kg/day.
Croatian: Povećani broj kromosomskih aberacija zabilježen je u perifernim limfocitima bolesnika s leukemijom, u bolesnika s karcinomom bubrežnih stanica koji je primao nepoznatu dozu 6-merkaptopurina te u bolesnika s kroničnom bolešću bubrega liječenih dozama od 0,4 do 1,0 mg/kg/danu.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti nuspojave su prikazane od najozbiljnije prema manje ozbiljnima.
English: 6-mercaptopurine, in common with other antimetabolites, is mutagenic and causes chromosomal aberrations in vitro and in vivo in mice and rats.
Croatian: 6-merkaptopurin, kao i drugi antimetaboliti, mutagen je i uzrokuje kromosomske aberacije in vitro i in vivo u miševa i štakora.
English: Therefore close monitoring of blood counts is necessary.
Croatian: Stoga je potrebno pomno praćenje krvne slike.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Take as directed by your doctor using the dosing syringes provided.
Croatian: NAČIN I PUT(EVI) PRIMJENE LIJEKA Lijek uzimajte prema uputama liječnika pomoću priloženih štrcaljki za doziranje.
English: Amber type III glass bottle with tamper evident child-resistant closure (HDPE with expanded polyethylene liner) containing 100 ml of oral suspension.
Croatian: Smeđa staklena bočica tipa III sa zatvaračem sigurnim za djecu s evidencijom otvaranja (HDPE s ekspandiranim polietilenskim umetkom) koja sadrži 100 ml oralne suspenzije.
English: A possible association between decreased TPMT activity and secondary leukaemias and myelodysplasia has been reported in individuals receiving 6-mercaptopurine in combination with other cytotoxics (see section 4.8).
Croatian: Moguća povezanost smanjenja aktivnosti TPMT-a i sekundarnih leukemija i mijelodisplazija uočena je u osoba koji primaju 6-merkaptopurin u kombinaciji s drugim citotoksičnim lijekovima (vidjeti dio 4.8).
English: Xaluprine contains aspartame (E951) which contains a source of phenylalanine.
Croatian: Xaluprine sadrži aspartam (E591) koji sadrži izvor fenilalanina.
English: Patients with little or no inherited TPMT activity are at increased risk for severe toxicity from conventional doses of mercaptopurine and generally require substantial dose reduction.
Croatian: Bolesnici s naslijeđenom niskom aktivnošću ili nepostojanjem aktivnosti TPMT-a pod povećanim su rizikom od izrazite toksičnosti standardnih doza merkaptopurina te im je općenito potrebno znatno smanjiti dozu.
English: Careful monitoring of haematological parameters should be conducted during therapy.
Croatian: Tijekom liječenja potrebno je pažljivo pratiti hematološke parametre.
English: The 6-mercaptopurine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions.
Croatian: 6-merkaptopurina inhibiraju de novo sintezu purina i interkonverziju purinskih nukleotida.
English: Ensure that the cap is tightly closed.
Croatian: Pazite da zatvarač bude čvrsto zatvoren.
English: However, it is advisable to monitor renal and hepatic function in these patients, and if there is any impairment, consideration should be given to reducing the Xaluprine dose.
Croatian: No, preporučuje se nadzor funkcije bubrega i jetre u ovih bolesnika te, u slučaju bilo kakvog oštećenja, eventualno smanjenje doze Xaluprina.
English: Wipe up spillages immediately.
Croatian: Odmah pobrišite proliveni lijek.
English: The smaller 1 ml syringe (purple), marked from 0.1 ml to 1 ml, is for measuring doses of less than or equal to 1 ml.
Croatian: Manja štrcaljka od 1 ml (ljubičasta), graduirana od 0,1 ml do 1 ml, služi za mjerenje doza manjih ili jednakih 1 ml.
English: During remission induction when rapid cell lysis is occurring, uric acid levels in blood and urine should be monitored as hyperuricaemia and/or hyperuricosuria may develop, with the risk of uric acid nephropathy.
Croatian: Tijekom indukcije remisije kada dolazi do izrazitog raspadanja stanica, potrebno je pratiti razinu urične kiseline u krvi i mokraći zbog mogućnosti razvoja hiperuricemije i/ili hiperurikozurije te posljedično akutne uratne nefropatije.
English: Serum antiepileptic levels should be closely monitored during treatment with Xaluprine, making dose adjustments as necessary.
Croatian: Serumske razine antiepileptika potrebno je pomno pratiti tijekom liječenja Xaluprineom te prema potrebi prilagođavati dozu.
English: Multiple congenital abnormalities have been reported following maternal 6-mercatopurine treatment in combination with other chemotherapy agents.
Croatian: Višestruke kongenitalne malformacije zabilježene su nakon liječenja majke 6-merkaptopurinom u kombinaciji s drugim kemoterapijskim agensima.
English: * In patients with inflammatory bowel disease (IBD), an unlicensed indication.
Croatian: *U bolesnika s upalnom bolesti crijeva (UBC), nije odobrena indikacija.
English: Gastrointestinal effects, including nausea, vomiting and diarrhoea and anorexia may be early symptoms of overdose having occurred.
Croatian: Učinci na probavni sustav, uključujući mučninu, povraćanje i proljev te anoreksiju mogu biti rani simptomu predoziranja.
English: In any case, close monitoring of blood counts is necessary.
Croatian: U svakom slučaju, potrebno je pomno praćenje krvne slike.
English: It also contains sodium methyl parahydroxybenzoate and sodium ethyl parahydroxybenzoate which may cause allergic reaction (possibly delayed).
Croatian: Također sadrži natrijev metilparahidroksibenzoat i natrijev etilparahidroksibenzoat koji mogu uzrokovati alergijske reakcije (koje mogu biti odgođene).