FrancophonIA/ELRC3.0 huggingface dataset:
English: Rare: may affect up to 1 in 1,000 people - Liver failure (including fatal outcome) - Hepatitis - Fatty liver - Increased blood levels of bilirubin (a breakdown product of haemoglobin) - Dehydration (when the body does not have enough water) - Thinning of the face - Bleeding in the brain* (see above) - Increased blood levels of the pancreas enzyme lipase
Croatian: Rijetko: mogu se javiti u do 1 na 1000 osoba - zatajenje jetre (uključujući fatalan ishod) - hepatitis - masna jetra - povišene vrijednosti bilirubina u krvi (razgradni produkt hemoglobina) - dehidracija (kada vaše tijelo nema dovoljno vode) - stanjivanje lica - krvarenje u mozgu* (vidjeti gore) - povišene vrijednosti lipaze, enzima gušterače, u krvi
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with simvastatin or lovastatin are contra-indicated due to an increased risk of myopathy, including rhabdomyolysis (see section 4.3).
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i simvastatina ili lovastatina je kontraindicirana zbog povećanog rizika od miopatije, uključujući rabdomiolizu (vidjeti dio 4.3).
English: The maximum volume you can withdraw at one time is 5 ml (equivalent to 500 mg tipranavir), which is the maximum single dose for a child with BSA (Calculated body surface area) > 1.33 m
Croatian: Maksimalni volumen koji možete izvući u jednom trenutku je 5 ml (odgovara 500 mg tipranavira), što je maksimalna jednostruka doza za dijete s površinom tijela > 1,33 m2 Okrenite bocu naopačke i nježno izvucite potrebnu količinu Aptivus oralne otopine.
English: Didanosine 200 mg BID, ≥ 60 kg (TPV/r 250/200 mg BID) - 125 mg BID, < 60 kg (TPV/r 750/100 mg BID)
Croatian: Didanozin 200 mg BID, ≥ 60 kg (TPV/r 250/200 mg BID)125 mg BID, < 60 kg (TPV/r 750/100 mg BID)
English: 25-O-desacetylrifabutin Cmin ↑ 7.8 fold
Croatian: 25-O-dezacetilrifabutin Cmin ↑ 7,8 puta
English: Conclusions regarding the relevance of particular mutations or mutational patterns are subject to change with additional data, and it is recommended to always consult current interpretation systems for analysing resistance test results.
Croatian: Praktično značenje određenih mutacija ili mutacijskih obrazaca podložno je promjenjivim interpretacijama sukladno novim podacima.
English: Herbal preparations containing St. John's wort must not be combined with Aptivus, co-administered with low dose ritonavir.
Croatian: Biljni pripravci koji sadrže gospinu travu ne smiju se kombinirati s Aptivusom uz nisku dozu ritonavira.
English: Aptivus is contraindicated in patients with moderate or severe (Child-Pugh Class B or C) hepatic insufficiency.
Croatian: Aptivus je kontraindiciran u bolesnika s umjerenom ili teškom (Child-Pugh stadij B ili C) insuficijencijom jetre.
English: At tipranavir exposures in rats at 0.8-fold human exposure at the clinical dose, foetal toxicity (decreased sternebrae ossification and body weights) was observed.
Croatian: U štakora pri sistemskoj izloženosti tipranaviru koja je 20% niža od one koja se postiže u ljudi klinički preporučenom dozom, primijećena je fetalna toksičnost (smanjena osifikacija sternuma, smanjena tjelesna težina).
English: The HMG-CoA reductase inhibitors simvastatin and lovastatin are highly dependent on CYP3A for metabolism.
Croatian: Metabolizam simvastatina i lovastatina uvelike ovisi o CYP3A.
English: emtricitabine: If you are taking emtricitabine your kidney function should be checked before initiation of Aptivus.
Croatian: Ako uzimate emtricitabin potrebno je provjeriti Vašu bubrežnu funkciju prije početka primjene Aptivusa.
English: Genotypic or phenotypic testing (when available) and treatment history should guide the use of Aptivus.
Croatian: Odluku valja temeljiti na rezultatima genotipskog ili fenotipskog testiranja (kada je dostupno) te povijesti liječenja.
English: Phenobarbital and phenytoin should be used with caution in combination with Aptivus, co-administered with low dose ritonavir (see section 4.4).
Croatian: Fenobarbital i fenitoin se primjenjuju s oprezom u kombinaciji s Aptivusom, uz nisku dozu ritonavira (vidjeti dio 4.4).
English: Treatment response is presented for the overall population (displayed by enfuvirtide use), and detailed by PI strata for the subgroup of patients with genotypically resistant strains in the Table below.
Croatian: Terapijski odgovar prikazan je za ukupnu populaciju (prema (ne)primjeni enfuvirtida), te detaljno po stratumima prema IP za bolesnike s genotipski rezistentnim sojevima (vidjeti tablicu).
English: Therefore, tipranavir with ritonavir should not be used in treatment-naïve patients.
Croatian: Stoga se tipranavir s ritonavirom ne smije primjenjivati u liječenju prethodno neliječenih bolesnika.
English: Then give the next dose of Aptivus and ritonavir at the regularly scheduled time.
Croatian: Zatim uzmite sljedeću dozu Aptivusa i ritonavira u redovno vrijeme, prema režimu doziranja.
English: This will depend on, for example: which other medicines your child has already taken for HIV which medicines your child's HIV is resistant to.
Croatian: Djetetov liječnik će odlučiti, u suradnji s Vama, koje druge lijekove Vaše dijete treba uzimati, što će ovisiti na primjer: o tome koje druge lijekove je dijete već uzimalo protiv HIV-a o tome na koje lijekove je HIV Vašeg djeteta otporan.
English: Concentrations of cyclosporin, tacrolimus, or sirolimus cannot be predicted when co-administered with tipranavir co-administered with low dose ritonavir, due to conflicting effect of tipranavir, coadministered with low dose ritonavir, on CYP 3A and P-gp.
Croatian: Koncentracije ciklosporina, takrolimusa ili sirolimusa ne mogu se predvidjeti kad se istodobno primjenjuju s tipranavirom uz nisku dozu ritonavira, zbog suprotnog učinka tipranavira s niskom dozom ritonavira na CYP 3A i Pgp.
English: co-administration of tipranavir with low dose ritonavir and alfuzosin results in increased alfuzosin concentrations and may result in hypotension.
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i niskom dozom ritonavira i alfuzosina rezultira povećanim koncentracijama alfuzosina te može rezultirati hipotenzijom.
English: Ritonavir acts by inhibiting hepatic cytochrome P450 CYP3A, the intestinal P-glycoprotein (P-gp) efflux pump and possibly intestinal cytochrome P450 CYP3A as well.
Croatian: Ritonavir inhibira P450 CYP3A u jetri, crijevni P-glikoprotein (efluksna pumpa), te možda također crijevni P450
English: Co-administration of colchicine with Aptivus/ritonavir in patients with renal or hepatic impairment (see section 4.5).
Croatian: Istodobna primjena kolhicina s Aptivusom/ritonavirom u bolesnika s oštećenjem bubrega ili jetre (vidjeti dio 4.5).
English: Aptivus soft capsules co-administered with low dose ritonavir should be taken with food (see section
Croatian: Aptivus meke kapsule, uz istodobnu primjenu niske doze ritonavira, uzimaju se s hranom (vidjeti dio
English: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthrosis in patients with haemophilia type A and B treated with protease inhibitors.
Croatian: Prijavljeni su slučajevi pojačanog krvarenja, uključujući spontane hematome i hemartrozu, u bolesnika s hemofilijom tipa
English: General disorders and administration site conditions common fatigue uncommon pyrexia, influenza like illness, malaise
Croatian: Opći poremećaji i reakcije na mjestu primjene često umor manje često pireksija, bolest slična gripi, malaksalost
English: Check that the oral solution is clear (see below).
Croatian: Provjerite je li oralna otopina bistra (u nastavku).
English: Concomitant use of tipranavir, co-administered with low dose ritonavir, and fluticasone or other glucocorticoids that are metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section 4.5).
Croatian: Istodobna primjena tipranavira s niskom dozom ritonavira, i flutikazona ili drugih glukokortikoida koji se metaboliziraju putem CYP3A4 se ne preporučuju, osim ako potencijalni pozitivni učinci liječenja ne nadilaze rizik od sistemskih kortikosteroidnih učinaka, uključujući Cushingov sindrom i adrenalnu supresiju (vidjeti dio 4.5).
English: Musculoskeletal and connective tissue disorders uncommon myalgia, muscle spasms
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva manje često mialgija, mišićni spazmi
English: NAME OF THE MEDICINAL PRODUCT Aptivus 250 mg soft capsules
Croatian: NAZIV LIJEKA Aptivus 250 mg meke kapsule
English: Of note, patients in the RESIST studies had a specific mutational pattern at baseline of at least one primary protease gene mutation among codons 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V or 90M, and no more than two mutations on codons 33, 82, 84 or 90.
Croatian: Valja napomenuti da su ispitanici u RESIST ispitivanjima imali specifičan mutacijski obrazac na početku od najmanje jedne primarne mutacije proteaze u kodonima 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V ili 90M te ne više od dvije mutacije u kodonima 33, 82, 84 ili 90.
English: APV/rtv FAS PP
Croatian: APV/rtv Svi ispitanici PP
English: Plasma concentrations of tipranavir can be reduced by concomitant use of the herbal preparation St John's wort (Hypericum perforatum).
Croatian: Koncentracije tipranavira u plazmi mogu se smanjiti uz istodobnu primjenu pripravka gospine trave (Hypericum perforatum) zbog indukcije metabolizirajućih enzima.
English: Due to their metabolic profile and inherent risk of inducing torsades de pointes, administration of halofantrine and lumefantrine with Aptivus, co-administered with low dose ritonavir, is not recommended (see section 4.4).
Croatian: Zbog njihovog metaboličkog profila i inherentnog rizika od indukcije torsades de pointes, ne preporučuje se primjena halofantrina i lumefantrina s Aptivusom, s niskom dozom ritonavira (vidjeti dio 4.4).
English: Your child must not take products containing St John's wort (a herbal remedy for depression).
Croatian: Vaše dijete ne smije uzimati proizvode koji sadrže gospinu travu (biljni lijek protiv depresije), jer ona može spriječiti ispravno djelovanje Aptivusa.
English: Based on theoretical considerations, colchicine concentrations may increase upon co-administration with tipranavir and low dose ritonavir, due to tipranavir/ritonavir CYP3A and P-gp inhibition.
Croatian: Temeljem teoretskih razmatranja, koncentracije kolhicina mogu se povećati nakon istodobne primjene s tipranavirom i niskom dozom tipranavira, zbog inhibicije CYP3A i P-gp tipranavirom/ritonavirom.
English: Also, appropriate dose adjustments for children under 12 years cannot be achieved with Aptivus capsules.
Croatian: Također se ne mogu provoditi prilagodbe doziranja Aptivus kapsula za djecu ispod 12 godina starosti.
English: If you have:
Croatian: - emtricitabin:
English: At least one primary protease gene mutation from among 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V or 90M had to be present at baseline, with not more than two mutations on codons 33, 82, 84 or 90.
Croatian: Morala je biti prisutna najmanje jedna od primarnih mutacija gena za proteazu: 30N, 46I, 46L, 48V, 50V, 82A, 82F, 82L, 82T, 84V ili 90M, s ne više od dvije mutacije u kodonima 33, 82, 84, ili 90.
English: S-methadone Cmax ↓ 62% S-methadone AUC ↓ 63%
Croatian: S-metadon Cmax ↓ 62% S-metadon AUC ↓ 63%
English: Compared to the oral solution, tipranavir exposure is lower when administering the same dose as capsules.
Croatian: U usporedbi s oralnom otopinom, izlaganje tipranaviru je manje prilikom primjene jednake doze u obliku kapsula.
English: 25-O-desacetylrifabutin Cmax ↑ 3.2 fold
Croatian: 25-O-dezacetilrifabutin Cmax ↑ 3,2 puta
English: 500 mg Tipranavir co-administered with low dose ritonavir (200 mg; twice daily) was associated with a 29-fold increase in the geometric mean morning steady-state trough plasma concentrations compared to tipranavir 500 mg twice daily without ritonavir.
Croatian: 500 mg tipranavira s niskom dozom ritonavira (200 mg; dvaput dnevno) daje 29 puta višu geometrijsku srednju vrijednost jutarnje najniže koncentracije tipranavira na kraju doznog intervala u stanju dinamičke ravnoteže nego 500 mg tipranavira dva puta dnevno bez ritonavira.
English: If patients did not receive tipranavir with ritonavir with new enfuvirtide, diminished treatment responses at week 48 were observed, relative to new enfuvirtide use (see Table below).
Croatian: Ako „novi“ enfuvirtid nije uveden, terapijski odgovor u 48. tjednu bio je slabiji nego uz primjenu „novog“ enfuvirtida (vidjeti tablicu u nastavku).
English: - 500 mg (two 250 mg capsules) Aptivus together with - 200 mg (two 100 mg capsules) ritonavir twice per day with food.
Croatian: Preporučena doza za odrasle ili adolescente dobi od 12 i više godina je: - 500 mg (dvije kapsule od 250 mg) Aptivusa zajedno s - 200 mg (dvije kapsule od 100 mg) ritonavira dvaput dnevno s hranom.
English: Tell your doctor if you receive medicines such as blood-thinning agents, or if you are taking vitamin E. Your doctor may wish to consider certain precautionary measures in such circumstances.
Croatian: Obavijestite liječnika ako uzimate lijekove kao što su lijekovi za razrjeđivanje krvi, ili ako uzimate vitamin E.
English: Variable
Croatian: Varijabla
English: ALAT increased
Croatian: Povišeni ALT
English: Pink, oblong soft gelatin capsules imprinted with “TPV 250” in black.
Croatian: Ružičasta, duguljasta meka kapsula od želatine s, crnom bojom, utisnutim „TPV 250“.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/05/315/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/05/315/001
English: RESIST participants receiving Aptivus with ritonavir tended to have an increased risk of bleeding; at 24 weeks the relative risk was 1.98 (95% CI=1.03, 3.80).
Croatian: Ispitanici u RESIST studiji koji su dobivali Aptivus s ritonavirom, imali su povećan rizik krvarenja; nakon 24 tjedna, relativni rizik bio je 1,98 (95% CI=1,03; 3,80).
English: Data suggest that, although ritonavir is a P-gp inhibitor, the net effect of Aptivus, coadministered with low dose ritonavir, at the proposed dose regimen at steady-state, is P-gp induction.
Croatian: Dostupni podaci sugeriraju da je, iako je ritonavir P-gp inhibitor, učinak Aptivusa s niskom dozom ritonavira na aktivnost P-gp u stanju dinamičke ravnoteže indukcija.
English: In an open-label, dose-finding study of tipranavir plus ritonavir (Trial 1182.14), 62 children aged 2 to 12 years received Aptivus oral solution.
Croatian: U otvorenom ispitivanju određivanja doze tipranavira s ritonavirom (ispitivanje 1182.14), 28 djece u dobi od 12-18 godina dobivalo je Aptivus kapsule.
English: You should therefore carefully read the Package Leaflets of ritonavir and your child's other antiretroviral medicines.
Croatian: Prema tome, pažljivo pročitajte upute koje se prilažu uz ritonavir i druge antiretrovirusne lijekove koje primjenjuje Vaše dijete.
English: Depending on your child's liver function they may have to delay or stop Aptivus treatment - if your child is currently taking products containing: - rifampicin (used to treat tuberculosis) - cisapride (used to treat stomach problems) - pimozide or sertindole (used to treat schizophrenia) - quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder) - lurasidone (used to treat schizophrenia) - triazolam or oral midazolam (taken by mouth).
Croatian: Ovisno o funkciji jetre Vašeg djeteta, možda će se morati odgoditi ili prekinuti liječenje Aptivusom - ako Vaše dijete trenutno uzima lijekove koji sadrže: - rifampicin (primjenjuje se u liječenju tuberkuloze) - cisaprid (primjenjuje se u liječenju želučanih problema) - pimozid ili sertindol (primjenjuju se u liječenju shizofrenije) - kvetiapin (primjenjuje se u liječenju shizofrenije, bipolarnog poremećaja i velikog depresivnog poremećaja) - lurasidon (primjenjuje se u liječenju shizofrenije) - triazolam ili oralni midazolam (uzimaju se oralno).
English: This score (counting the 16 amino acids that have been associated with reduced tipranavir susceptibility and/or reduced viral load response: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D and 84V) was applied to baseline viral protease sequences.
Croatian: Ovaj skor (koji broji 16 aminokiselina koje su povezane sa smanjenom osjetljivošću na tipranavir i/ili smanjenim učinkom na virusno opterećenje: 10V, 13V, 20M/R/V, 33F, 35G, 36I, 43T, 46L, 47V, 54A/M/V, 58E, 69K, 74P, 82L/T, 83D i 84V) je primijenjen na početne virusne proteazne sekvence.
English: In the case of tipranavir co-administered with low dose ritonavir, concomitant use with rifampicin is expected to result in sub-optimal levels of tipranavir which may lead to loss of virologic response and possible resistance to tipranavir.
Croatian: U slučaju primjene tipranavira, uz nisku dozu ritonavira, očekuje se da istodobna primjena rifampicina rezultira sniženom ekspozicijom tipranaviru, što može dovesti do gubitka virusnog odgovora i moguće otpornosti na tipranavir.
English: Based on theoretical considerations, tipranavir or ritonavir concentrations might increase upon co-administration with itraconazole or ketoconazole.
Croatian: Temeljem teoretskih razmatranja, koncentracije tipranavira ili ritonavira mogu se povećati nakon istodobne primjene s itrakonazolom ili ketokonazolom.
English: Proportion of patients achieving treatment response at Week 48 (confirmed ≥1 log10 copies/ml decrease in viral load compared to baseline), according to tipranavir baseline mutation score and enfuvirtide use in RESIST patients
Croatian: Udio bolesnika s terapijskim odgovorom nakon 48. tjedna (potvrđeno smanjenje virusnog opterećenja ≥1 log10 kopija/ml u usporedbi s početkom), u odnosu na početni „mutacijski skor“ i primjenu enfuvirtida u bolesnika u RESIST
English: Protease inhibitors
Croatian: Inhibitori proteaze
English: No dosage adjustment necessary.
Croatian: Nije potrebno podešavanje doza.
English: You must take Aptivus in combination with low dose ritonavir and other antiretroviral medicines.
Croatian: Morate uzimati Aptivus u kombinaciji s niskom dozom ritonavira uz druge antiretrovirusne lijekove.
English: Reactivation of herpes simplex and herpes zoster virus infections were observed in the RESIST trials.
Croatian: U ispitivanjima RESIST primijećena je reaktivacija infekcija virusom herpes simpleks i herpes zoster.
English: Analyses of tipranavir resistance in treatment experienced patients Tipranavir with ritonavir response rates in the RESIST studies were assessed by baseline tipranavir genotype and phenotype.
Croatian: Analiza otpornosti tipranavira u bolesnika s iskustvom u liječenju Stopa terapijskog odgovora na tipranavir s ritonavirom u RESIST kliničkim ispitivanjima analizirana je u odnosu na početni virusni genotip i fenotip.
English: No clinically significant change is observed in tipranavir PK parameters.
Croatian: Nije primijećena klinički značajna promjena farmakokinetike tipranavira.
English: 3 in the comparator PI/ritonavir (N=727) arm.
Croatian: 3za kontrolnu skupinu (N=727).
English: - If you have any further questions, please ask your doctor or your pharmacist.
Croatian: - Ako imate dodatnih pitanja, obratite se liječniku ili ljekarniku.
English: Tipranavir, co-administered with low dose ritonavir, exhibits linear pharmacokinetics at steady state.
Croatian: Tipranavir s niskom dozom ritonavira u stanju dinamičke ravnoteže pokazuje linearnu farmakokinetiku.
English: Isolates with baseline fold change of >0 to 3 are considered susceptible; isolates with >3 to 10 fold changes have decreased susceptibility; isolates with >10 fold changes are resistant.
Croatian: Izolati koji rastu jednako brzo ili do 3 puta brže u prisustvu tipranavira od divljeg soja virusa smatraju se osjetljivima na tipranavir; izolati s >3 do 10 puta bržim rastom smanjeno su osjetljivi, a izolati koji rastu >10 puta brže su rezistentni.
English: % with Category C 29.2% Treatment history % with any ARV 96.6% Median # previous
Croatian: % sa skupinom C 29,2% Anamneza liječenja % s bilo kojim ARV medijan broja prethodnih NRTI medijan broja prethodnih NNRTI medijan broja prethodnih IP * ADI - AIDS defining illness: stanje koje definira AIDS
English: - If your child gets any side effects, talk to your child's doctor or pharmacist.
Croatian: - Ako Vaše dijete dobije bilo koju nuspojavu, potrebno je obavijestiti djetetovog liječnika ili ljekarnika.
English: Your child must take Aptivus in combination with low dose ritonavir and other antiretroviral medicines.
Croatian: Vaše dijete mora uzimati Aptivus u kombinaciji s niskom dozom ritonavira uz druge antiretrovirusne lijekove.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each ml contains 100 mg tipranavir
Croatian: NAVOĐENJE DJELATNE(IH) TVARI Jedan ml sadrži 100 mg tipranavira
English: Switching from Aptivus oral solution to the capsules Aptivus oral solution is not interchangeable with the capsules.
Croatian: Aptivus oralna otopina nije zamjenjiva s kapsulama.
English: If you notice any symptoms of infection (for example fever, enlarged lymph nodes), please inform your child's doctor immediately.
Croatian: Ako primijetite simptome infekcije (na primjer vrućica, povećani limfni čvorovi) kod Vašeg djeteta, odmah se obratite djetetovom liječniku.
English: The oral clearance of tipranavir decreased after the addition of ritonavir which may represent diminished first-pass clearance of the substance at the gastrointestinal tract as well as the liver.
Croatian: Klirens tipranavira nakon peroralne primjene smanjio se nakon dodavanja ritonavira, što može biti posljedica smanjenog klirensa „prvog prolaza“ u probavnom sustavu i/ili jetri.
English: Based on theoretical considerations, bosentan concentrations may increase upon co-administration with tipranavir and low dose ritonavir.
Croatian: Temeljem teoretskih razmatranja, koncentracije bosentana se mogu povećati nakon istodobne primjene s tipranavirom uz nisku dozu ritonavira.
English: Abacavir Cmax ↓ 46% Abacavir AUC ↓ 36%
Croatian: Abakavir Cmax ↓ 46% Abakavir AUC ↓ 36%
English: Concomitant use of rilpivirine with some ritonavir-boosted protease inhibitors has demonstrated an increase in the plasma concentrations of rilpivirine.
Croatian: Pokazalo se da istodobna primjena rilpivirina s pojedinim inhibitorima proteaze pojačanima ritonavirom uzrokuje povišenje koncentracije rilpivirina u plazmi.
English: Ergot derivatives Dihydroergotamine Ergonovine Ergotamine Methylergonovine No interaction study performed
Croatian: Derivati ergota Dihidroergotamin Ergonovin
English: Tell your child's doctor if your child receives medicines such as blood-thinning agents, or if your child is taking vitamin E. Your child's doctor may wish to consider certain precautionary measures in such circumstances.
Croatian: Obavijestite djetetovog liječnika ako Vaše dijete uzima lijekove kao što su lijekovi za razrjeđivanje krvi ili ako uzima vitamin E.
English: NAME OF THE MEDICINAL PRODUCT Aptivus 250 mg soft capsules tipranavir
Croatian: NAZIV LIJEKA Aptivus 250 mg meke kapsule tipranavir
English: The clinical relevance of this reduction in didanosine concentrations has not been established.
Croatian: Klinički značaj ovog smanjenja koncentracija didanozina nije utvrđen.
English: Elimination Administration of
Croatian: Eliminacija Primjena
English: Midazolam Cmax ↔ Midazolam AUC ↑ 5.1 fold
Croatian: Midazolam Cmax ↔ Midazolam AUC ↑ 5,1 puta
English: Clarithromycin Cmax ↔ Clarithromycin AUC ↑ 19% Clarithromycin Cmin ↑ 68%
Croatian: Antibiotici Klaritromicin 500 mg BID Klaritromicin Cmax ↔ Klaritromicin AUC ↑ 19% Klaritromicin Cmin ↑ 68%
English: RESIST participants receiving tipranavir with ritonavir tended to have an increased risk of bleeding; at 24 weeks the relative risk was 1.98 (95% CI=1.03, 3.80).
Croatian: Bolesnici u RESIST kliničkom ispitivanju koji su dobivali tipranavir s ritonavirom imali su povećan rizik krvarenja; nakon 24 tjedna relativni rizik iznosio je 1,98 (95% CI=1,03; 3,80).