FrancophonIA/ELRC3.0 huggingface dataset:
English: If you stop using Rhokiinsa the pressure in your eye will not be controlled which could lead to loss of sight.
Croatian: Ako prestanete primjenjivati lijek Rhokiinsa, vaš očni tlak neće biti reguliran, što može dovesti do gubitka vida.
English: • Gently squeeze the bottle to release one drop of Rhokiinsa into your eye.
Croatian: • Nježno pritisnite bočicu kako biste pustili jednu kap lijeka Rhokiinsa u svoje oko.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/19/1400/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/19/1400/001
English: The safety of netarsudil has been evaluated in clinical studies, including four well-controlled Phase 3 studies.
Croatian: Sigurnost netarsudila ocjenjivala se u kliničkim ispitivanjima, uključujući četiri dobro kontrolirana ispitivanja faze 3.
English: With the exception of the incidence of cornea verticillata, no other difference in safety profile was observed between races or age groups (see section 4.8).
Croatian: Uz iznimku incidencije pojave cornea verticillata, nije bilo drugih razlika u sigurnosnom profilu između rasa ili dobnih skupina (vidjeti dio 4.8).
English: The tip of the dispensing container should avoid contacting the eye, surrounding structures, fingers, or any other surface in order to avoid contamination of the solution.
Croatian: Vrh spremnika s otopinom ne bi trebao doći u kontakt s okom, okolnim strukturama, prstima ili bilo kakvom drugom površinom kako bi se izbjegla kontaminacija otopine.
English: The cornea verticillata seen in netarsudil-treated patients were first noted at 4 weeks of daily dosing.
Croatian: Cornea verticillata opažena u bolesnika liječenih netarsudilom prvi je put primijećena 4 tjedna nakon svakodnevne primjene.
English: Animal studies with intravenous administration do not indicate direct or indirect harmful effects with respect to reproductive toxicity at clinically relevant exposures (see section 5.3).
Croatian: Ispitivanja na životinjama s intravenskom primjenom ne ukazuju na izravan ili neizravan štetan učinak u pogledu reproduktivne toksičnosti kod klinički relevantne izloženosti (vidjeti dio 5.3).
English: Twice a day dosing is not well tolerated and is not recommended.
Croatian: Učinci na oči Primjena doze dva puta dnevno ne podnosi se dobro te se ne preporučuje.
English: Approximately 75% of subjects included in the netarsudil treatment groups of Phase 3 studies were Caucasian and 24% Black or African American.
Croatian: Približno 75 % ispitanika uključenih u skupine liječene netarsudilom u ispitivanjima faze 3 bilo je bijele rase, a 24 % ispitanika bilo je crne rase ili su bili Afroamerikanci.
English: Intravenous administration of netarsudil mesylate to pregnant rats and rabbits during organogenesis did not produce adverse embryofetal effects at clinically relevant systemic exposures.
Croatian: Intravenska primjena netarsudilmesilata u skotnih ženki štakora i kunića tijekom organogeneze nije imala negativne embriofetalne učinke kod klinički relevantnih sistemskih izloženosti.
English: After opening the bottle: Do not store above 25°C.
Croatian: Nakon otvaranja bočice: ne čuvati na temperaturi iznad 25 °C.
English: Discard 4 weeks after first opening.
Croatian: Baciti 4 tjedana nakon prvog otvaranja.
English: Rhokiinsa should not be used during pregnancy unless the clinical condition of the woman requires treatment with netarsudil.
Croatian: Rhokiinsa ne smije se primjenjivati tijekom trudnoće osim ako kliničko stanje žene ne zahtijeva liječenje netarsudilom.
English: • General side effects: Headache
Croatian: • Opće nuspojave: glavobolja
English: Subjects with known contraindications or hypersensitivity to timolol were excluded from the studies.
Croatian: Ispitanici s poznatim kontraindikacijama ili preosjetljivosti na timolol isključeni su iz ispitivanja.
English: Do not use Rhokiinsa if you are pregnant unless your doctor still recommends it.
Croatian: Lijek Rhokiinsa nemojte primjenjivati ako ste trudni, osim ako vam je to liječnik preporučio.
English: If netarsudil is to be used concomitantly with other topical ophthalmic medicinal products, each medicinal product should be administered at least five (5) minutes apart.
Croatian: Ako se netarsudil namjerava istodobno primjenjivati s drugim oftalmološkim lijekovima za topikalnu primjenu, svakog od njih potrebno je primijeniti s minimalnim razmakom od pet (5) minuta.
English: Day 43
Croatian: 43. dan
English: After topical ocular dosing, netarsudil is metabolised by esterases in the eye to an active metabolite, AR-13503.
Croatian: Nakon topikalne okularne primjene, netarsudil metaboliziraju esteraze u oku do aktivnog metabolita, AR-13503.
English: Reactions are classified according to the convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000) or not known (cannot be estimated from the available data).
Croatian: < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000) ili nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Conjunctival hyperaemia was the most frequently reported adverse reaction associated with netarsudil treatment in clinical trials and it is attributed to the vasodilation effect of the Rho kinase inhibitor drug class.
Croatian: Konjunktivalna hiperemija bila je najčešće prijavljivana nuspojava povezana s liječenjem netarsudilom u kliničkim ispitivanjima, a pripisuje se vazodilatacijskom učinku lijekova iz klase inhibitora Rho kinaze.
English: Pharmacotherapeutic group: Ophthalmologicals, antiglaucoma preparations and miotics, ATC code: S01EX05
Croatian: Farmakoterapijska skupina: oftalmološki lijekovi, pripravci protiv glaukoma i miotici, ATK oznaka: S01EX05
English: Netarsudil and its active metabolite AR-13503 was found to have a possible phototoxic potential in a modified 3T3 NRU-PT in vitro assay, where the wavelength was extended to include UVB light.
Croatian: Netarsudil i njegov aktivni metabolit AR-13503 imaju moguć fototoksični potencijal u modificiranom in vitro testu 3T3 NRU-PT, u kojemu je valna duljina produžena tako da uključuje UVB zračenje.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Croatian: Detaljne informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu.
English: Benzalkonium chloride may also cause eye irritation, especially if you have dry eyes or disorders of the cornea (the clear layer at the front of the eye).
Croatian: Benzalkonijev klorid također može uzrokovati nadražaj oka, osobito ako imate suhe oči ili poremećaje rožnice (prozirni sloj prednjeg dijela oka).
English: Discontinuation rates due to adverse reactions were 19.3% for the netarsudil treatment group versus 1.7% for the timolol maleate group.
Croatian: Stope prekida liječenja zbog nuspojava bile su 19,3 % za skupinu liječenu netarsudilom nasuprot 1,7 % za skupinu liječenu timolol maleatom.
English: It should be used with caution in dry eye patients and in patients where the cornea may be compromised.
Croatian: Potrebno je primjenjivati s oprezom kod bolesnika sa suhim okom i bolesnika kod kojih rožnica može biti ugrožena.
English: The most common ocular adverse reaction observed is conjunctival hyperemia which was reported in 51% of patients.
Croatian: Najčešća opažena nuspojava povezana s očima je konjunktivna hiperemija, koja je prijavljena u 51 % bolesnika.
English: The majority of cornea verticillata resolved upon discontinuation of treatment.
Croatian: Većina slučajeva cornea verticillata prošla je nakon prestanka liječenja.
English: INFORMATION IN BRAILLE Rhokiinsa
Croatian: 16. PODATCI NA BRAILLEOVOM PISMU Rhokiinsa
English: Marketing Authorisation Holder and Manufacturer Aerie Pharmaceuticals Ireland, Limited Athlone Business and Technology Park, Dublin Road,
Croatian: NOSITELJ ODOBRENJA ZA STAVLJANJE U PROMET Aerie Pharmaceuticals Ireland, Limited Athlone Business and Technology Park, Dublin Road,
English: If transient blurred vision occurs at instillation, the patient should wait until the vision clears before driving or using machines.
Croatian: Ako dođe do kratkotrajnog zamućenja vida prilikom ukapavanja kapi u oko, bolesnik mora pričekati da mu vid ponovno postane bistar prije upravljanja vozilima ili rada sa strojevima.
English: Timolol 0.5% twice daily Difference (95% CI) Netarsudil - Timolol
Croatian: Razlika (95 % CI) Netarsudil - Timolol
English: Twice a day dosing was also associated with a higher discontinuation rate due to adverse reactions (53.8%) during a 12-month study.
Croatian: Primjena doze dva puta dnevno također je povezana s većom stopom prekida liječenja zbog nuspojava (53,8 %) tijekom ispitivanja od 12
English: The incidence of cornea verticillata was higher in certain subpopulations: elderly (≥65 years) versus non-elderly (24.8 vs. 15.9%); males versus females (24.4 vs. 18.4%) and in white versus other races (25.6 vs. 7.0%).
Croatian: osobe starije dobi (≥ 65 godina) u usporedbi s osobama koje nisu starije dobi (24,8 nasuprot 15,9 %); muškarci u usporedbi s ženama (24,4 nasuprot 18,4 %) te osobe bijele rase u usporedbi s pripadnicima drugih rasa (25,6 nasuprot 7,0 %).
English: The recommended dose is one drop in the affected eye or eyes once a day in the evening.
Croatian: Preporučena je doza jedna kap u oboljelo oko ili oči jednom dnevno navečer.
English: PARTICULARS TO APPEAR ON OUTER PACKAGING OUTER CARTON
Croatian: PODATCI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA
English: Cornea verticillata occurred in approximately 20% of the patients in controlled Phase 3 clinical studies.
Croatian: Cornea Verticillata Cornea verticillata (vrtložasta keratopatija) pojavila se u otprilike 20 % bolesnika u kontroliranom kliničkom ispitivanju faze 3.
English: Patients should not instill more than one drop in the affected eye(s) each day.
Croatian: Bolesnici ne bi smjeli ukapati više od jedne kapi u oboljelo oko (oči) na dan.
English: Contact lenses should be removed prior to instillation of netarsudil and may be reinserted 15 minutes following its administration (see section 4.4).
Croatian: Potrebno je ukloniti kontaktne leće prije ukapavanja netarsudila, a može ih se vratiti 15 minuta nakon primjene (vidjeti dio 4.4).
English: Do not use this medicine after the expiry date which is stated on the bottle and the carton after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na bočici i kutiji iza oznake
English: • Do not touch your eye, eyelid, surrounding areas or other surfaces with the dropper.
Croatian: • Nemojte kapaljkom dodirivati svoje oko, kapak, okolni dio ili druge površine.
English: Netarsudil 0.02% Once daily
Croatian: 0,02-tni % netarsudil jednom dnevno
English: You may find that your vision is blurred or abnormal just after using Rhokiinsa.
Croatian: Možda će vam vid biti zamagljen ili promijenjen neposredno nakon primjene lijeka Rhokiinsa.
English: There were no quantifiable plasma concentrations of netarsudil (lower limit of quantitation (LLOQ) 0.100 ng/ml) post dose on day 1 and day 8.
Croatian: Nije bilo mjerljivih koncentracija netarsudila u plazmi (niža granica kvantifikacije (LLOQ) 0,100 ng/ml) nakon primjene doze prvog dana i osmog dana.
English: Once opened, do not store above 25°C.
Croatian: Nakon otvaranja, ne čuvati na temperaturi iznad 25 °C.
English: Over half were aged ≥ 65 years.
Croatian: Više od polovice bilo je u dobi
English: The efficacy and safety of netarsudil in subjects with compromised corneal epithelium or co-existing ocular pathologies e.g. pseudoexfoliation and dispersion pigment syndrome has not been established.
Croatian: Djelotvornost i sigurnost netarsudila kod ispitanika s narušenim epitelom rožnice ili istodobno postojećim patološkim stanjima oka, npr. pseudo-eksfolijacijom i sindromom disperzije pigmenta nije ustanovljena.
English: Benzalkonium chloride, boric acid, mannitol, sodium hydroxide, water for injections.
Croatian: Benzalkonijev klorid, boratna kiselina, manitol, natrijev hidroksid, voda za injekcije.
English: The non-inferiority margin applied was a difference in mean IOP ≤1.5 mmHg for all time points over all visits through 3 months and ≤1.0 mmHg at a majority of these time points.
Croatian: Primijenjena granica za neinferiornost bila je razlika u srednjoj vrijednosti IOT-a manja od 1,5 mmHg za sve vremenske točke mjerenja tijekom svih posjeta u vremenskom razdoblju od 3 mjeseca, te manje od 1,0 mmHg za većinu tih točaka mjerenja.
English: Effects in non-clinical studies were observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use.
Croatian: U nekliničkim ispitivanjima zapaženi su učinci samo pri izloženostima koje su znatno veće od izloženosti u ljudi pri maksimalnim dozama, što ukazuje na njihov mali značaj za kliničku primjenu.
English: What Rhokiinsa is and what it is used for
Croatian: Što se nalazi u ovoj uputi: Što je Rhokiinsa i za što se koristi
English: • Put back the bottle cap to close the bottle.
Croatian: • Stavite čep nazad na bočicu i zatvorite je.
English: Only one plasma concentration at 0.11 ng/ml for the active metabolite was observed for one subject on day 8 at 8 hours post-dose.
Croatian: Samo jedna koncentracija od 0,11 mg/ml u plazmi pojavila se za aktivni metabolit kod jednog ispitanika osmog dana osam sati nakon primjene doze.
English: System Organ Classification
Croatian: Klasifikacija organskih sustava
English: Rhokiinsa contains benzalkonium chloride This medicine contains approximately 150 micrograms benzalkonium chloride in each ml of solution.
Croatian: Rhokiinsa sadrži benzalkonijev klorid Ovaj lijek sadrži približno 150 mikrograma benzalkonijevog klorida u jednom ml otopine.
English: Other medicines and Rhokiinsa Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako primjenjujete, nedavno ste primijenili ili biste mogli primijeniti bilo koje druge lijekove.
English: - The other excipients are benzalkonium chloride (see section 2 under ‘Rhokiinsa contains benzalkonium chloride'), mannitol, boric acid, sodium hydroxide and water for injections.
Croatian: - Druge pomoćne tvari su benzalkonijev klorid (vidjeti dio 2. pod podnaslovom Rhokiinsa sadrži benzalkonijev klorid), manitol, boratnu kiselinu, natrijev hidroksid i vodu za injekcije.
English: Netarsudil was not mutagenic in a bacterial mutation assay, in a mouse lymphoma assay, or in a rat micronucleus test.
Croatian: Netarsudil nije pokazao mutagenost u testu bakterijske mutacije, testu mišjeg limfoma ili u mikronukleus testu kod štakora.
English: The most frequently reported adverse reactions associated with discontinuation in the Rhokiinsa groups were conjunctival hyperemia (5.8%), cornea verticillata (3.7%) and vision blurred (1.4%).
Croatian: Najčešće prijavljivane nuspojave povezane s prekidom liječenja u grupi koja je koristila lijek Rhokiinsa bile su konjunktivna hiperemija (5,8 %), cornea verticillata (3,7 %) i zamućen vid (1,4 %).
English: What you need to know before you use Rhokiinsa Do not use Rhokiinsa: - if you are allergic to netarsudil or any of the other ingredients of this medicine (listed in section
Croatian: Nemojte primjenjivati lijek Rhokiinsa: - ako ste alergični na netarsudil ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: A randomised, double-blind, multicentre Phase 3 clinical trial compared the efficacy and safety of netarsudil once daily with that of timolol maleate 0.5% twice daily in reducing IOP in a total of 708 patients with open-angle glaucoma or ocular hypertension.
Croatian: Klinička djelotvornost i sigurnost Nasumičnim, dvostruko slijepim, multicentričnim kliničkim ispitivanjem faze 3 usporedila se djelotvornost i sigurnost netarsudila koji se primjenjivao jednom dnevnom s 0,5 %-tnim timolol maleatom koji se primjenjivao dva puta dnevno za smanjivanje IOT-a kod ukupno 708 bolesnika s glaukomom otvorenog kuta ili okularnom hipertenzijom.
English: These studies also suggest that netarsudil lowers IOP by reducing episcleral venous pressure.
Croatian: Ta ispitivanja također pokazuju da netarsudil smanjuje IOT smanjivanjem episkleralnog venskog tlaka.
English: This medicinal product contains benzalkonium chloride.
Croatian: Ovaj lijek sadrži benzalkonijev klorid.
English: There are no data on the effects of netarsudil on male or female fertility.
Croatian: Nema podataka o učincima netarsudila na plodnost u ljudi.
English: Netarsudil demonstrated clinically relevant reductions in IOP at all timepoints, however non-inferiority to timolol was not demonstrated in this population with baseline IOP ≥25 mmHg and <30 mmHg (Table 2).
Croatian: Netarsudil je pokazao klinički relevantna smanjenja IOT-a u svim vremenskim točkama mjerenja, međutim nije pokazana neinferiornost u odnosu na timolol kod ove populacije s početnom vrijednosti IOT-a ≥ 25 mmHg i < 30 mmHg (Tablica 2.).
English: The systemic exposures of netarsudil and its active metabolite, AR-13503, were evaluated in 18 healthy subjects after topical ocular administration of netarsudil once daily (one drop bilaterally in the morning) for 8 days.
Croatian: Sistemska izloženost netarsudilu i njegovom aktivnom metabolitu, AR-13503, procijenjena je kod 18 zdravih ispitanika nakon topikalne okularne primjene netarsudila jednom dnevno (jedna kap u oba oka svako jutro) tijekom 8 dana.
English: The incidences of hyperemia and vision blurred were sporadic in nature.
Croatian: Incidencije hiperemije i zamućenog vida bile su sporadične prirode.
English: In pregnant rats, 0.3 mg/kg/day (1000 times the recommended ophthalmic dose) and higher showed increased postimplantation loss and reduced foetal viability.
Croatian: U skotnih ženki štakora, 0,3 mg/kg/dan (1000 puta više od preporučene oftalmološke doze) i više pokazalo je da dolazi do povećanog postimplantacijskog gubitka i smanjenog fetalnog preživljenja.
English: Rhokiinsa is supplied sterile in opaque white low density polyethylene bottles (2.5 ml fill in a 4 ml container) and tips with white polypropylene caps and anti-tamper seals.
Croatian: Lijek Rhokiinsa dostavlja se sterilan u neprozirnoj bijeloj bočici od polietilena niske gustoće (2,5 ml otopine u spremniku od 4 ml) s vrhom zatvorenim bijelim čepom od polipropilena s evidencijom otvaranja.
English: Netarsudil dosed twice daily provided slightly larger IOP reductions, but had a less favorable safety profile as reflected in a higher rate and increased severity of ocular adverse reactions.
Croatian: Primjena doze netarsudila dva puta dnevno dovela je do malo većeg smanjenja IOT-a, ali ima nepovoljniji sigurnosni profil s obzirom na veću stopu i težinu nuspojava povezanih s očima.
English: It is therefore recommended to dose netarsudil once daily.
Croatian: Stoga je preporučeno doziranje netarsudila jedanput dnevno.
English: Day 15
Croatian: Početna vrijednost 15. dan
English: Instillation site erythema (8%), corneal staining (7%), blurred vision (6%), increased lacrimation (6%) and erythema of eyelid (5%) were also reported.
Croatian: Također su prijavljeni i eritem na mjestu primjene (8 %), obojanost rožnice (7 %), zamućeni vid (6 %), povećano izlučivanje suza (6 %) i eritem kapka
English: However, while no effects on the breastfed newborn/infant are anticipated since the systemic exposure of breast-feeding women to netarsudil is expected to be negligible, no relevant clinical data are available (see section 5.2).
Croatian: Međutim, iako se ne očekuju učinci na dojeno novorođenče/dojenče jer se očekuje da će sistemska izloženost dojilje netarsudilu biti zanemariva, o tome nema dostupnih relevantnih kliničkih podataka (vidjeti dio 5.2).
English: Rhokiinsa is used to lower pressure in the eyes in adults who have an eye condition known as glaucoma or who have raised pressure in their eyes.
Croatian: Rhokiinsa se upotrebljava za smanjenje tlaka u oku u odraslih koji imaju bolest očiju koja se zove glaukom ili koji imaju povišen očni tlak.
English: Netarsudil, a Rho kinase inhibitor, is believed to reduce IOP by increasing outflow of aqueous humor.
Croatian: Za netarsudil, inhibitor Rho kinaze, se smatra da smanjuje IOT povećanjem otjecanja očne vodice.
English: • Twist off the bottle cap, and lie the cap on a clean surface on its side.
Croatian: • Odvrnite čep bočice i polegnite ga bočno na čistu površinu.
English: Other ocular adverse reactions reported are: cornea verticillata (17%), instillation site pain (17%), and conjunctival haemorrhage (8%).
Croatian: Druge prijavljene nuspojave povezane s očima su: cornea verticillata (17 %), bol na mjestu primjene (17 %) i konjunktivalno krvarenje (8 %).
English: No effects during pregnancy are anticipated, since systemic exposure to netarsudil is negligible (see section 5.2).
Croatian: Ne očekuju se učinci tijekom trudnoće, budući da je sistemska izloženost netarsudilu zanemariva (vidjeti dio 5.2).
English: Each ml of solution contains 150 micrograms benzalkonium chloride.
Croatian: Jedan ml otopine sadrži 150 mikrograma benzalkonijevog klorida.
English: In pregnant rabbits, 3 mg/kg/day (10000 times the recommended ophthalmic dose) and higher showed an increase in post-implantation loss and a decrease in foetal weight.
Croatian: U skotnih ženki kunića kod primjene 3 mg/kg/dan (10 000 puta više od preporučene oftalmološke doze) i više pokazalo se da dolazi do povećanog gubitka postimplantacijskog gubitka te do smanjenja težine fetusa.
English: Conjunctival hyperaemia was typically mild in severity and sporadic.
Croatian: Konjunktivna hiperemija bila je obično blažeg oblika i pojavljivala se sporadično.
English: Rhokiinsa is indicated for the reduction of elevated intraocular pressure (IOP) in adult patients with primary open-angle glaucoma or ocular hypertension.
Croatian: Lijek Rhokiinsa indiciran je za smanjenje povišenog intraokularnog tlaka (IOT) u odraslih bolesnika s primarnim glaukomom otvorenog kuta ili očnom hipertenzijom.
English: • Do not touch the dropper with your fingers when opening or closing the bottle.
Croatian: • Kada otvarate ili zatvarate bočicu, kapaljku nemojte dodirivati prstima.
English: The majority of discontinuations in the netarsudil group were associated with ocular adverse reactions, whereas the majority of discontinuations in the timolol group were associated with non-ocular adverse reactions.
Croatian: Većina prekida liječenja u skupini koja je liječena netarsudilom imala je veze s nuspojavama povezanima s okom, dok je većina prekida liječenja u skupini liječenoj timololom imala veze s nuspojavama koje nisu bile povezane s okom.
English: Completion rates in Phase 3 studies were lower in the netarsudil treatment group when compared with the timolol maleate group.
Croatian: Stope završetka ispitivanja u ispitivanjima faze 3 bile su niže u skupini koja je liječena netarsudilom, u usporedbi sa stopama završetka ispitivanja u skupini liječenoj timolol maleatom.
English: Continue to hold the bottle, ensuring that the tip doesn't come into contact with anything.
Croatian: Držite bočicu pazeći da vrh ništa ne dotakne.
English: If topical overdose of netarsudil should occur, the eye(s) may be flushed with tap water.
Croatian: Ako dođe do topikalnog predoziranja netarsudilom, oko (oči) se može (mogu) isprati vodom iz slavine.
English: Benzalkonium chloride has been reported to cause eye irritation, symptoms of dry eyes and may affect the tear film and corneal surface and is known to discolour soft contact lenses.
Croatian: Za benzalkonijev klorid je zabilježeno da uzrokuje iritaciju oka, simptome suhog oka, te može utjecati na suzni film i površinu rožnice.
English: No data on potential interactions specific to netarsudil is currently available (see section 4.5).
Croatian: Trenutačno nema dostupnih podataka o mogućim interakcijama specifičnim za netarsudil (vidjeti dio
English: Warnings and precautions • Do not use Rhokiinsa more than once a day, as you may experience more side effects.
Croatian: • Nemojte upotrebljavati lijek Rhokiinsa više od jednom dnevno, jer to može povećati broj nuspojava.
English: visual field defect
Croatian: ispad vidnog polja