FrancophonIA/ELRC3.0 huggingface dataset:
English: During long-term treatment, some patients may develop structural changes in the kidney (e.g. interstitial fibrosis) which, in renal transplant patients, must be differentiated from changes due to chronic rejection.
Slovenian: Pri nekaterih bolnikih lahko pri dolgotrajnem zdravljenju pride do strukturnih sprememb v ledvicah (na primer do intersticijske fibroze), ki jih je pri bolnikih po presaditvi ledvice treba razlikovati od sprememb, ki so posledica kronične zavrnitve presadka.
English: If any of these affects you severely, tell your doctor.
Slovenian: Če vas kateri koli od teh učinkov huje prizadene, obvestite svojega zdravnika.
English: For inducing remission, initially 5 mg/kg/day orally given in 2 divided doses are recommended until remission of active uveal inflammation and improvement in visual acuity are achieved.
Slovenian: Za indukcijo remisije je priporočeni začetni odmerek 5 mg/kg/dan peroralno v dveh deljenih odmerkih, dokler se aktivno vnetje žilnice ne umiri in ne pride do izboljšanja ostrine vida.
English: A decision should be made whether to abstain from breast-feeding or to abstain from using the medicinal drug, taking into account the importance of the medicinal product to the mother.
Slovenian: Odločiti se je treba med prenehanjem dojenja ali prenehanjem zdravljenja z zdravilom, pri čemer je treba pretehtati prednosti zdravljenja za mater.
English: PHARMACEUTICAL FORM AND CONTENTS Capsule, soft [To be completed nationally]
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA kapsula, mehka
English: In such cases an initial oral loading dose of 10 to 12.5 mg/kg should be given, followed by daily oral administration of the maintenance dose previously found to be satisfactory.
Slovenian: V takih primerih je priporočljivo začeti s polnitvenim peroralnim odmerkom 10 do 12,5 mg/kg, nato pa nadaljevati z dnevnim peroralnim vzdrževalnim odmerkom, ki se je že prej izkazal kot zadovoljiv.
English: In view of the potential risk of skin malignancy, patients on Sandimmun, in particular those treated for psoriasis or atopic dermatitis, should be warned to avoid excess unprotected sun exposure and should not receive concomitant ultraviolet B irradiation or PUVA photochemotherapy.
Slovenian: Glede na možnost razvoja malignih obolenj kože je treba bolnike, še posebno tiste, ki uporabljajo zdravilo Sandimmun za zdravljenje psoriaze ali atopijskega dermatitisa, opozoriti, naj se nezaščiteni izogibajo čezmernemu izpostavljanju sončni svetlobi in da se ne smejo sočasno zdraviti z ultravijoličnimi žarki B ali fotokemoterapijo PUVA.
English: These reactions can consist of flushing of the face and upper thorax, and non-cardiogenic pulmonary oedema, with acute respiratory distress, dyspnoea, wheezing, blood pressure changes and tachycardia.
Slovenian: Te reakcije lahko vključujejo nenadno pordelost obraza in zgornjega dela prsnega koša, nekardiogeni pljučni edem z akutno dihalno stisko, dispnejo, piskajoče dihanje, spremembo krvnega tlaka in tahikardijo.
English: • Bleeding underneath the skin or purple skin patched, sudden bleeding with no apparent cause.
Slovenian: • podkožne krvavitve ali vijolične lise v koži (podplutbe), nenadna krvavitev brez očitnega vzroka
English: However, if it is almost time for your next dose, skip the missed dose.
Slovenian: Če je že skoraj čas za naslednji odmerek, izpustite pozabljeni odmerek in nadaljujte po ustaljenem razporedu.
English: Your doctor might check the level of ciclosporin in your blood when starting or stopping treatment with other medicines.
Slovenian: Zdravnik bo verjetno preveril koncentracijo ciklosporina v vaši krvi, kadar vam bo uvedel ali ukinil katero od drugih zdravil.
English: If eGFR decreases by more than 25% below baseline at more than one measurement, the dosage of Sandimmun should be reduced by 25 to 50%.
Slovenian: Če se ocenjena hitrost glomerulne filtracije zniža za več kot 25 % pod izhodiščno vrednost pri več kot eni meritvi, je treba odmerek zdravila Sandimmun znižati za 25 do 50 %.
English: Draw up the prescribed volume of solution (position the lower part of the plunger ring in front of the graduation corresponding to the prescribed volume).
Slovenian: Potegnite predpisano količino raztopine v brizgo (bat brizge nastavite tako, da bo spodnji del poravnan z oznako, ki ustreza predpisanemu volumnu).
English: if you have low levels of magnesium in your body.
Slovenian: • če imate znižano koncentracijo magnezija v telesu.
English: Additional precautions in nephrotic syndrome
Slovenian: Dodatna opozorila pri nefrotskem sindromu
English: ANNEX III SUMMARY OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET
Slovenian: POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJE IN NAVODILO ZA UPORABO
English: Ciclosporin appears to block the resting lymphocytes in the G0 or G1 phase of the cell cycle, and inhibits the antigen-triggered release of lymphokines by activated T-cells.
Slovenian: Kaže, da ciklosporin ustavi mirujoče limfocite v fazi G0 ali G1 fazi celičnega cikla in zavira sproščanje limfokinov iz aktiviranih celic T v odziv na stik z antigenom.
English: Octreotide decreases oral absorption of ciclosporin and a 50% increase in the ciclosporin dose or a switch to intravenous administration could be necessary.
Slovenian: Oktreotid zmanjša peroralno absorpcijo ciklosporina, tako da je lahko potrebno 50-odstotno zvišanje odmerka ciklosporina ali prehod na intravensko odmerjanje.
English: Ciclosporin increases the exposure to HMG-CoA reductase inhibitors (statins).
Slovenian: Ciklosporin povečuje izpostavljenost zaviralcem HMG-CoA reduktaze (statinom).
English: Pharmacokinetic data from paediatric patients given Sandimmun Neoral or Sandimmun are very limited.
Slovenian: Farmakokinetičnih podatkov pediatričnih bolnikov, ki so prejemali zdravilo Sandimmun Neoral ali Sandimmun, je zelo malo.
English: Sandimmun contains approximately 12.0 vol. % ethanol (alcohol), which corresponds to up to 500 mg per dose used in transplant patients.
Slovenian: Zdravilo Sandimmun vsebuje približno 12,0 vol. % etanola (alkohola), kar pomeni največ 500 mg na odmerek pri bolnikih s presadkom.
English: For severe rash, the treatment usually lasts for 8 weeks.
Slovenian: Za zdravljenje hude oblike atopijskega dermatitisa traja zdravljenje običajno 8 tednov.
English: Multiple dose administration of ambrisentan and ciclosporin in healthy volunteers resulted in an approximately 2-fold increase in ambrisentan exposure, while the ciclosporin exposure was marginally increased (approximately 10%).
Slovenian: Večkratno odmerjanje ambrisentana in ciklosporina je pri zdravih prostovoljcih povzročilo približno 2kratno povečanje izpostavljenosti ambrisentanu, pri tem pa je bila izpostavljenost ciklosporinu le malo povečana (za približno 10 %).
English: Special caution should be observed if Sandimmun is used in combination with methotrexate due to nephrotoxic synergy.
Slovenian: Posebna previdnost je potrebna pri uporabi zdravila Sandimmun v kombinaciji z metotreksatom zaradi sinergističnega toksičnega delovanja na ledvice.
English: Following concomitant administration of ciclosporin and aliskiren, a P-gp substrate, the Cmax of aliskiren was increased approximately 2.5-fold and the AUC approximately 5-fold.
Slovenian: Po sočasni uporabi ciklosporina in aliskirena, ki je substrat P-glikoproteina, se je Cmax aliskirena zvišala približno 2,5-krat, njegova AUC pa se je povečala približno 5-krat.
English: Nephrotic syndrome
Slovenian: Nefrotski sindrom
English: The estimated glomerular filtration rate (eGFR) by the MDRD formula can be used for estimation of renal function in adults and an appropriate formula should be used to assess eGFR in paediatric patients.
Slovenian: Za oceno ledvične funkcije je pri odraslih mogoče uporabiti ocenjeno hitrost glomerulne filtracije (angl. estimated glomerular filtration rate, eGFR) po MDRD formuli, pri pediatričnih bolnikih pa je treba za oceno hitrosti glomerulne filtracije uporabiti drugo ustrezno formulo.
English: Medicinal products known to reduce or increase the bioavailability of ciclosporin: In transplant patients frequent measurement of ciclosporin levels and, if necessary, ciclosporin dosage adjustment is required, particularly during the introduction or withdrawal of the co-administered medication.
Slovenian: Zdravila, za katera je znano, da zmanjšujejo ali povečujejo biološko uporabnost ciklosporina: Pri prejemnikih presadkov je potrebno pogosto določanje koncentracije ciklosporina in po potrebi prilagajanje odmerjanja ciklosporina, zlasti v obdobju uvajanja ali ukinjanja sočasnega zdravila.
English: Subsequent use Commence at point 5.
Slovenian: Začnite pri 5. koraku.
English: Pregnant women receiving immunosuppressive therapies after transplantation, including ciclosporin and ciclosporin-containing regimens, are at risk of premature delivery (<37 weeks).
Slovenian: Pri nosečnicah, ki so po presaditvi prejemale imunosupresivno zdravljenje, vključno s ciklosporinom in shemami, ki vsebujejo ciklosporin, obstaja tveganje za prezgodnji porod (pred dopolnjenim 37. tednom nosečnosti).
English: Hyperuricaemia Caution is required when treating patients with hyperuricaemia.
Slovenian: Hiperurikemija Pri zdravljenju bolnikov s hiperurikemijo je potrebna previdnost.
English: The concomitant use of diclofenac and ciclosporin has been found to result in a significant increase in the bioavailability of diclofenac, with the possible consequence of reversible renal function impairment.
Slovenian: Ugotovili so, da sočasna uporaba diklofenaka in ciklosporina pomembno poveča biološko uporabnost diklofenaka, kar lahko povzroči reverzibilno okvaro ledvične funkcije.
English: Products containing Hypericum perforatum (St John´s Wort) must not be used concomitantly with Sandimmun due to the risk of decreased blood levels of ciclosporin and thereby reduced effect (see section 4.3).
Slovenian: Pripravkov, ki vsebujejo Hypericum perforatum (šentjanževko), se ne sme uporabljati sočasno z zdravilom Sandimmun zaradi tveganja za znižanje koncentracije ciklosporina v krvi in s tem zmanjšanje njegovega delovanja (glejte poglavje 4.3).
English: Pre-existing infections may also be aggravated and reactivation of polyomavirus infections may lead to polyomavirus-associated nephropathy (PVAN) or to JC virus associated progressive multifocal leukopathy (PML).
Slovenian: Prav tako lahko pride do poslabšanja že prej prisotnih okužb in do reaktivacije okužb s poliomavirusom, kar lahko povzroča s poliomavirusom povezano nefropatijo (Polyomavirus associated nephropathy - PVAN) ali z virusom JC povezano progresivno multifokalno levkoencefalopatijo (PML).
English: Exposure changes of commonly used statins with ciclosporin are summarised in Table 1.
Slovenian: Spremembe izpostavljenosti nekaterih pogosto uporabljanih statinov pri sočasni uporabi s ciklosporinom so prikazane v preglednici 1.
English: • High level of sugar in your blood.
Slovenian: • zvišana raven sladkorja v krvi
English: Sandimmun should not be given to children for a non-transplant disease, except for treatment of nephrotic syndrome.
Slovenian: Zdravila Sandimmun se ne sme dajati otrokom z boleznimi, ki niso povezane s presaditvijo organa, razen pri zdravljenju nefrotskega sindroma.
English: In several studies, paediatric patients required and tolerated higher doses of ciclosporin per kg body weight than those used in adults.
Slovenian: Več pediatričnih raziskav je pokazalo, da otroci tako potrebujejo kot prenašajo višje odmerke ciklosporina na kg telesne mase kot odrasli.
English: • The active substance is ciclosporin.
Slovenian: • Zdravilna učinkovina je ciklosporin.
English: If no improvement has been observed after this time to improvement period, Sandimmun therapy should be discontinued.
Slovenian: Če po navedenem obdobju ni opaziti izboljšanja, je treba zdravljenje z zdravilom Sandimmun prekiniti.
English: Examples are:
Slovenian: Primeri takih učinkovin so:
English: For maintenance treatment, the dose should be slowly reduced to the lowest effective level.
Slovenian: Za vzdrževalno zdravljenje je treba odmerek postopoma znižati na najnižjo še učinkovito raven.
English: All inhibitors of CYP3A4 and/or P-glycoprotein may lead to increased levels of cyclosporine.
Slovenian: Vsi zaviralci CYP3A4 in/ali P-glikoproteina lahko povzročajo zvišano koncentracijo ciklosporina.
English: If the eGFR decrease from baseline exceeds 35%, further reduction of the dose of Sandimmun should be considered.
Slovenian: Če znižanje ocenjene hitrosti glomerulne filtracije od izhodiščne vrednosti presega 35 %, je treba razmisliti še o nadaljnjem znižanju odmerka zdravila Sandimmun.
English: Patients receiving immunosuppressive therapies, including ciclosporin and ciclosporin-containing regimens, are at increased risk of infections (viral, bacterial, fungal, parasitic) (see section 4.4).
Slovenian: Pri bolnikih, ki prejemajo imunosupresivno zdravljenje, vključno s ciklosporinom in shemami zdravljenja, ki vsebujejo ciklosporin, obstaja povečano tveganje za okužbe (virusne, bakterijske, glivične in parazitske) (glejte poglavje 4.4).
English: Because of the risk of anaphylaxis (see section 4.4) the use of Sandimmun concentrate for solution for infusion should be reserved for organ transplant patients who are unable to take the medicinal product orally (e.g. shortly after surgery), or in whom absorption of the oral forms might be impaired during episodes of gastrointestinal disorders.
Slovenian: Zaradi tveganja za anafilaksijo (glejte poglavje 4.4) je uporaba zdravila Sandimmun koncentrat za raztopino za infundiranje namenjena samo za bolnike po presaditvi organov, kadar ne morejo jemati zdravila peroralno (torej kmalu po operaciji), oziroma pri katerih bi absorpcijo peroralnih oblik lahko oviralo občasno pojavljanje gastrointestinalnih težav.
English: Imatinib could increase ciclosporin exposure and Cmax by around 20%.
Slovenian: Imatinib lahko poveča izpostavljenost ciklosporinu in zviša njegovo Cmax za približno 20 %.
English: This includes any possible side effects not listed in this leaflet.
Slovenian: Posvetujte se tudi, če opazite morebitne neželene učinke, ki niso navedeni v tem navodilu.
English: Treatment of sight-threatening intermediate or posterior uveitis of non-infectious aetiology in patients in whom conventional therapy has failed or caused unacceptable side effects.
Slovenian: Zdravljenje intermediarnega ali zadajšnjega uveitisa neinfektivne etiologije, ki ogroža vid, pri bolnikih, pri katerih običajno zdravljenje ni bilo uspešno ali pa je povzročalo nesprejemljive neželene učinke.
English: • Inflammation of the pancreas with severe upper stomach pain.
Slovenian: • vnetje trebušne slinavke s hudo bolečino v zgornjem delu trebuha
English: Amiodarone substantially increases the plasma ciclosporin concentration concurrently with an increase in serum creatinine.
Slovenian: Amiodaron precej zviša koncentracijo ciklosporina v plazmi s sočasnim zvišanjem koncentracije kreatinina v serumu.
English: Co-administration with telaprevir resulted in approximately 4.64-fold increase in ciclosporin dose normalised exposure (AUC).
Slovenian: Pri sočasni uporabi s telaprevirjem je prišlo do približno 4,64-kratnega povečanja izpostavljenosti ciklosporinu (AUC), normalizirane na odmerek.
English: Close monitoring of parameters that assess hepatic function is required and abnormal values may necessitate dose reduction (see sections 4.2 and 5.2).
Slovenian: Parametre za oceno jetrne funkcije je treba skrbno spremljati, v primeru patoloških vrednosti pa je lahko potrebno znižanje odmerka (glejte poglavji 4.2 in 5.2).
English: When to take Sandimmun Take Sandimmun at the same time every day.
Slovenian: Zdravilo Sandimmun jemljite vsak dan ob istem času.
English: Like other immunosuppressants, ciclosporin increases the risk of developing lymphomas and other malignancies, particularly those of the skin.
Slovenian: Tako kot drugi imunosupresivi tudi ciklosporin povečuje tveganje za razvoj limfoma in drugih malignih bolezni, še posebno malignih bolezni kože.
English: Like other immunosuppressants, ciclosporin predisposes patients to the development of a variety of bacterial, fungal, parasitic and viral infections, often with opportunistic pathogens.
Slovenian: Tako kot drugi imunosupresivi tudi ciklosporin poveča nagnjenost bolnikov k razvoju različnih bakterijskih, glivičnih, parazitskih in virusnih okužb, pogosto z oportunističnimi patogeni.
English: Sandimmun oral solution should be diluted in a glass (not plastic) container with cold chocolate drink, milk, fruit juice or cola immediately before being taken, stirred well and drunk at once.
Slovenian: Peroralno raztopino Sandimmun je treba tik pred zaužitjem razredčiti v steklenem (ne plastičnem) kozarcu s hladnim čokoladnim napitkom, mlekom, sadnim sokom ali kolo, jo dobro premešati in takoj izpiti.
English: Sandimmun suppresses the immune system and may also affect your body's ability to fight against infection.
Slovenian: Zdravilo Sandimmun zavira imunski sistem v telesu in lahko oslabi obrambno sposobnost telesa proti okužbam.
English: The medicine will be diluted before use with saline or 5% glucose and then given to you by slow infusion.
Slovenian: Zdravilo je treba razredčiti s fiziološko raztopino soli ali s 5-odstotno raztopino glukoze, prejeli pa ga boste s počasno infuzijo.
English: • Kidney problems which may greatly reduce the amount of urine you produce.
Slovenian: • okvara ledvic, zaradi katere lahko pride do močno zmanjšanega izločanjem urina;
English: High blood pressure.
Slovenian: • visok krvni tlak
English: • Migraine or severe headache often with feeling and being sick (nausea, vomiting) and being sensitive to light.
Slovenian: • migrena ali hud glavobol, pogosto z občutkom slabosti (z navzeo), z bruhanjem in s preobčutljivostjo na svetlobo
English: A slight precipitate that may occur during storage does not affect the efficacy and safety of the drug.
Slovenian: Med shranjevanjem se lahko pojavi manjša količina usedline, vendar ta ne vpliva na učinkovitost in varnost zdravila.
English: Before initiation of treatment a reliable baseline level of renal function should be established by at least two measurements.
Slovenian: Pred začetkom zdravljenja je treba določiti zanesljive vrednosti izhodiščne stopnje ledvične funkcije z najmanj dvema meritvama.
English: • If you have an autoimmune disease, in which your body's immune response attacks your body's own cells, Sandimmun stops this immune reaction.
Slovenian: • Če imate avtoimunsko bolezen, pri kateri vaš lasten imunski odziv napada celice vašega telesa, zdravilo Sandimmun zavira imunsko reakcijo pri taki bolezni.
English: More frequent checks are necessary when the Sandimmun dose is increased, or concomitant treatment with an NSAID is initiated or its dosage increased.
Slovenian: Pogostejše meritve so potrebne v času višanja odmerka zdravila Sandimmun ali uvajanja sočasnega zdravljenja z nesteroidnim protivnetnim zdravilom oziroma višanja njegovega odmerka.
English: A treatment regimen containing multiple immunosuppressants (including ciclosporin) should therefore be used with caution as this could lead to lymphoproliferative disorders and solid organ tumours, some with reported fatalities.
Slovenian: Iz tega razloga je pri uporabi shem zdravljenja, ki vsebujejo več imunosupresivov (vključno s ciklosporinom) potrebna previdnost, saj tako zdravljenje lahko povzroča limfoproliferativne bolezni in tumorje čvrstih organov, ki so se po poročilih v nekaterih primerih končali s smrtjo.
English: 50 ml amber glass bottles with an aluminium cap and rubber stopper.
Slovenian: 50-mililitrska steklenica iz rjavega stekla z aluminijasto zaporko in gumijastim zamaškom.
English: Atopic dermatitis
Slovenian: Atopijski dermatitis
English: If you are being treated for Behçet`s uveitis, your doctor will monitor you particularly carefully if you have neurological symptoms (for example: increased forgetfulness, personality changes noticed over time, psychiatric or mood disorders, burning sensation in limbs, decreased sensation in limbs, tingling sensation in limbs, weakness of limbs, walking disturbances, headache with or without nausea and vomiting, vision disturbances including restricted movement of eyeball).
Slovenian: Če prejemate zdravilo zaradi Behçetovega uveitisa, vas bo zdravnik še posebej skrbno pregledoval glede nevroloških simptomov (kot so: povečana pozabljivost, osebnostne spremembe, ki jih opazite sčasoma, psihiatrične motnje ali motnje razpoloženja, žgoč občutek v okončinah, zmanjšana občutljivost v okončinah, mravljinčenje v okončinah, oslabelost okončin, motnje hoje, glavobol z občutkom slabosti in bruhanjem ali brez njih, motnje vida, vključno z omejeno gibljivostjo očesa).
English: Ethanol: 100 mg/ml.
Slovenian: Etanol: 100 mg/ml.
English: This effect is often reversible with ciclosporin dose reduction.
Slovenian: Ta učinek je po znižanju odmerka ciklosporina pogosto reverzibilen.
English: Once satisfactory response is achieved, Sandimmun may be discontinued and subsequent relapse managed with re-introduction of Sandimmun at the previous effective dose.
Slovenian: Ko pride do zadovoljivega odziva, je mogoče zdravilo Sandimmun ukiniti, nadaljnje recidive pa zdraviti s ponovno uvedbo zdravila v odmerku, ki je bil prej učinkovit.
English: Less than 1% of the administered dose is removed by dialysis.
Slovenian: Z dializo se izloči manj kot 1 % danega odmerka.
English: Many side effects associated with ciclosporin therapy are dose-dependent and responsive to dose reduction.
Slovenian: Številni neželeni učinki ciklosporina so odvisni od odmerka in se odzivajo na znižanje odmerka.
English: Co-administration of ciclosporin significantly increases blood levels of everolimus and sirolimus.
Slovenian: Sočasna uporaba ciklosporina pomembno zviša koncentraciji everolimusa in sirolimusa v krvi.
English: This is because this medicine contains alcohol (see section below “Sandimmun contains ethanol”).
Slovenian: To je pomembno zato, ker zdravilo vsebuje alkohol (glejte poglavje v nadaljevanju "Zdravilo Sandimmun vsebuje etanol").
English: Your doctor may give you magnesium supplements to take, especially just after your operation if you have had a transplant.
Slovenian: Zdravnik vam bo morda svetoval uživanje nadomestkov z magnezijem, zlasti v obdobju takoj po operaciji, če ste prejeli presadek.
English: Various agents are known to either increase or decrease plasma or whole blood ciclosporin levels usually by inhibition or induction of enzymes involved in the metabolism of ciclosporin, in particular CYP3A4.
Slovenian: Za različna zdravila je znano, da bodisi zvišajo ali znižajo koncentracijo ciklosporina v plazmi ali polni krvi, običajno tako, da zavirajo ali inducirajo encime, ki sodelujejo pri presnovi ciklosporina, posebno encima CYP3A4.
English: Sandimmun prevents rejection of transplanted organs by blocking the development of certain cells which would normally attack the transplanted tissue.
Slovenian: Zdravilo Sandimmun preprečuje zavrnitev presajenega organa tako, da zavira razvoj posebnih celic, ki bi sicer napadle presajeno tkivo.
English: Elderly population (age 65 years and above) Experience with Sandimmun in the elderly is limited.
Slovenian: Populacija starejših (starih 65 let ali več) Izkušnje z zdravilom Sandimmun pri starejših bolnikih so omejene.
English: This is equivalent to nearly 15 ml beer or 5 ml wine per dose.
Slovenian: Ta količina ustreza približno 15 ml piva oziroma 5 ml vina na odmerek.
English: PHARMACEUTICAL FORM Concentrate for solution for infusion Clear, brown-yellow oleaginous concentrate.
Slovenian: FARMACEVTSKA OBLIKA koncentrat za raztopino za infundiranje Bister, rjavo rumen oljni koncentrat.
English: Keep taking Sandimmun for as long as your doctor tells you.
Slovenian: Zdravilo Sandimmun jemljite tako dolgo, kot vam naroči zdravnik.
English: This depends on your body weight and what you are being given the medicine for.
Slovenian: Odmerek je odvisen od vaše telesne mase in stanja, zaradi katerega prejemate zdravilo.
English: A 500 mg dose of Sandimmun contains 500 mg ethanol, equivalent to nearly 15 ml beer or 5 ml wine.
Slovenian: 500-miligramski odmerek zdravila Sandimmun vsebuje 500 mg etanola, kar ustreza skoraj 15 ml piva ali 5 ml vina.