FrancophonIA/ELRC3.0 huggingface dataset:
English: Supplied in packs of 1 vial or 10 vials.
Danish: Leveres i pakninger med 1 eller 10 hætteglas.
English: Seizures have been reported during clinical investigation in adult patients treated with ertapenem (1 g once a day) during therapy or in the 14-day follow-up period.
Danish: Under et klinisk studie er der rapporteret om kramper hos voksne i behandling med ertapenem (1 g en gang dagligt) eller i 14-dages opfølgningsperioden.
English: Due to the limited extent of hepatic metabolism of ertapenem, its pharmacokinetics are not expected to be affected by hepatic impairment.
Danish: På grund af ertapenems begrænsede levermetabolisme, formodes det ikke at farmakokinetikken påvirkes af leverinsufficiens.
English: These reactions are more likely to occur in individuals with a history of sensitivity to multiple allergens.
Danish: Der er større risiko for sådanne reaktioner hos patienter med overfølsomhed over for flere allergener i anamnesen.
English: Adverse reactions (i.e., considered by the investigator to be possibly, probably, or definitely related to the medicinal product) were reported in approximately 20 % of patients treated with ertapenem.
Danish: Der blev rapporteret utilsigtede reaktioner (dvs. af investigator betragtet som mulig, sandsynlig eller sikkert relateret til lægemidlet) hos ca. 20 % af patienterne behandlet med ertapenem.
English: Paediatric population (3 months to 17 years of age):
Danish: Pædiatrisk population (i alderen 3 måneder til 17 år):
English: Decreases in valproic acid levels that may fall below the therapeutic range have been reported when valproic acid was co-administered with carbapenem agents.
Danish: Der er set fald i koncentrationen af valproinsyre, som kan falde til under det terapeutiske interval, når valproinsyre blev administreret sammen med lægemidler med carbapenem.
English: If you miss a dose of INVANZ
Danish: Hvis De har fået for meget INVANZ
English: Investigations Chemistry
Danish: Undersøgelser Kemi
English: • Changes in some laboratory blood and urine tests
Danish: • Ændringer i visse blod- og urinprøver
English: The recommended dose of INVANZ for adults and adolescents 13 years of age and older is 1 gram (g) given once a day.
Danish: Den anbefalede dosis INVANZ til voksne og unge i alderen 13 år og ældre er 1 gram (g) 1 gang dagligt.
English: Because of the potential for adverse reactions on the infant, mothers should not breast-feed their infants while receiving ertapenem.
Danish: På grund af risiko for bivirkninger hos spædbørn, bør mødre ikke amme, mens de er i behandling med ertapenem.
English: Diluted solutions (approximately 20 mg/mL ertapenem) are physically and chemically stable for 6 hours at room temperature (25°C) or for 24 hours at 2 to 8°C (in a refrigerator).
Danish: Fortyndede opløsninger (ca. 20 mg/ml ertapenem) er fysisk og kemisk stabile i 6 timer ved stuetemperatur (25C) eller i 24 timer ved 2°C - 8C (i køleskab).
English: Peptostreptococcus species*
Danish: Peptostreptococcus arter*
English: No data are available in children under 3 months of age.
Danish: Der er ingen tilgængelige data for børn under 3 måneder.
English: Before initiating therapy with ertapenem, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, other beta-lactams and other allergens (see section 4.3).
Danish: Inden påbegyndelse med behandling med ertapenem, bør patienten nøje udspørges vedrørende tidligere overfølsomhedsreaktioner i forbindelse med penicillin, cefalosporiner, andre beta-laktamer samt andre allergener (se pkt.
English: In this age group, particular care should be taken to establish the susceptibility of the infecting organism(s) to ertapenem.
Danish: I denne aldersgruppe bør de inficerende organismers følsomhed over for ertapenem undersøges nøje.
English: There is no experience in children under 3 months of age.
Danish: Der er ikke erfaring med børn under 3 måneder.
English: Not known: Altered mental status (including aggression, delirium, disorientation, mental status changes)
Danish: Ikke kendt: Ændret mental status (inklusive aggression, delirium, desorientering, forandringer i mental status)
English: Tell your doctor if you are taking medicines called valproic acid or sodium valproate (see Other medicines and INVANZ below).
Danish: Fortæl det til lægen, hvis De tager medicin, der indeholder valproinsyre eller natriumvalproat (se Brug af anden medicin sammen med INVANZ nedenfor).
English: The plasma clearance (mL/min/kg) of ertapenem in patients 3 months to 12 years of age is approximately 2-fold higher as compared to that in adults.
Danish: Plasmaclearance (ml/min/kg) for ertapenem hos patienter i alderen 3 måneder - 12 år er ca. 2 gange højere end hos voksne.
English: Do not freeze solutions of INVANZ.
Danish: INVANZ opløsninger må ikke fryses.
English: The volume of distribution (Vdss) of ertapenem in adults is approximately 8 litres (0.11 litre/kg) and approximately 0.2 litre/kg in paediatric patients 3 months to 12 years of age and approximately 0.16 litre/kg in paediatric patients 13 to 17 years of age.
Danish: Ertapenems fordelingsvolumen (Vdss) hos voksne er ca. 8 liter (0,11 liter/kg) og ca. 0,2 liter/kg hos pædiatriske patienter i alderen 3 måneder - 12 år og ca. 0,16 liter/kg hos børn i alderen 13 - 17 år.
English: Experience in the use of ertapenem in the treatment of severe infections is limited.
Danish: Overvejelser vedrørende brug hos særlige populationer Der er begrænsede erfaringer i brugen af ertapenem ved behandling af svære infektioner.
English: Plasma concentrations following a 1 g and 2 g intravenous dose of ertapenem are slightly higher (approximately 39 % and 22 %, respectively) in healthy elderly adults (≥ 65 years) relative to young adults ( 65 years).
Danish: Plasmakoncentrationer efter intravenøs administration af henholdsvis 1 g og 2 g ertapenem er en anelse højere (henholdsvis ca. 39% og 22%) hos raske, ældre patienter ( 65 år) end hos unge voksne ( 65 år).
English: For patients who received only INVANZ, the following adverse reactions were reported during therapy plus follow-up for 14 days after treatment was stopped:
Danish: Hos patienter der udelukkende fik INVANZ, blev følgende utilsigtede relaterede reaktioner rapporteret i løbet af den behandling plus en 14 dages follow-up efter behandlingen blev seponeret:
English: Children (3 months to 12 years of age)
Danish: Børn (i alderen 3 måneder til 12 år)
English: The recommended dose for children 3 months to 12 years of age is 15 mg/kg given twice daily (not to exceed 1 g/day).
Danish: Den sædvanlige dosis for børn i alderen 3 måneder til 12 år er 15 mg/kg 2 gange dagligt (ikke over 1 g dagligt).
English: INVANZ is supplied in packs of 1 vial or 10 vials.
Danish: INVANZ fås i pakninger med 1 eller 10 hætteglas.
English: Uncommon: Oral candidiasis, candidiasis, fungal infection, pseudomembranous enterocolitis, vaginitis
Danish: Ikke almindelig: Oral candidiasis, svampeinfektion, pseudomembranøs enterocolitis, vaginitis
English: Adults: To prevent surgical site infections following elective colorectal surgery, the recommended dosage is 1 g administered as a single intravenous dose to be completed within 1 hour prior to the surgical incision.
Danish: Voksne: Til forebyggelse af infektioner på operationsstedet efter elektiv kolorektal operation er den anbefalede dosis 1 g indgivet som en enkelt intravenøs dosis, der skal være afsluttet inden for 1 time før indgrebet.
English: • Inflammation of the skin, fungal infection of the skin, skin peeling, infection of the wound after an operation
Danish: • Betændelse i huden, svampeinfektioner i huden, hudafskalning, infektion af sår efter operation
English: Following administration of a 1 g radiolabelled intravenous dose of ertapenem to healthy young adults (23 to 49 years of age), approximately 80 % is recovered in urine and 10 % in faeces.
Danish: Efter administration af 1 g radiomærket intravenøs dosis af ertapenem til raske, unge voksne (2349 år), genfindes ca. 80% i urinen og 10% i fæces.
English: Rare: Pneumonia, dermatomycosis, postoperative wound infection, urinary tract infection
Danish: Sjælden: Pneumoni, dermatomykose, postoperativ sårinfektion, urinvejsinfektion
English: Average concentrations of ertapenem in urine exceed 984 micrograms/mL during the period 0 to 2 hours postdose and exceed 52 micrograms/mL during the period 12 to 24 hours post-administration.
Danish: Gennemsnitlige koncentrationer af ertapenem i urinen er højere end 984 mikrogram/ml i perioden 0 - 2 timer efter administration og højere end 52 mikrogram/ml i perioden 12 - 24 timer efter administration.
English: • Gynaecological infections
Danish: • Gynækologisk infektion
English: • Skin infections of the foot in diabetic patients.
Danish: • Hudinfektion i foden hos sukkersyge (diabetes) patienter
English: Hepatic impairment No dosage adjustment is recommended in patients with impaired hepatic function (see section 5.2).
Danish: Nedsat leverfunktion Dosisjustering er ikke nødvendig til patienter med nedsat leverfunktion (se pkt.
English: White to off-white powder.
Danish: Hvidt/råhvidt pulver.
English: The major metabolite of ertapenem is the ring-opened derivative formed by dehydropeptidase-I-mediated hydrolysis of the beta-lactam ring.
Danish: Ertapenems hovedmetabolit dannes ved en dihydropeptidase-I-medieret hydrolytisk åbning af beta-laktamringen.
English: Uncommon: Decreases in white blood cells, platelet count, segmented neutrophils, haemoglobin and haematocrit; increases in eosinophils, activated partial thromboplastin time, prothrombin time, segmented neutrophils, and white blood cells Rare: Decrease in lymphocytes; increases in band neutrophils, lymphocytes, metamyelocytes, monocytes, myelocytes; atypical lymphocytes
Danish: Ikke almindelig: Fald i antal hvide blodlegemer, fald i trombocyttal og segmenterede neutrofiler, fald i hæmoglobin og hæmatokrit; stigning i eosinofiltal, øget APPT, øget protrombintid, stigning i segmenterede neutrofiler og hvide blodlegemer Sjælden: Fald i lymfocytter; stigning i båndneutrofiler, lymfocytter, metamyelocytter, monocytter og myelocytter; atypiske lymfocytter
English: INVANZ should not be used during pregnancy unless your doctor decides the potential benefit justifies the potential risk to the foetus.
Danish: INVANZ bør ikke anvendes under graviditet, med mindre lægen beslutter, at de forventede fordele opvejer den mulige risiko for fostret.
English: Excipient with known effect Each 1.0 g dose contains approximately 6.0 mEq of sodium (approximately 137 mg).
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver 1,0 g dosis indeholder ca. 6,0 mEq natrium (ca. 137 mg).
English: Treatment was discontinued due to adverse reactions in 0.5 % of patients.
Danish: Behandlingen blev seponeret hos 0,5 % af patienterne pga. bivirkninger.
English: • Agitation, anxiety, depression, tremor
Danish: • Ophidselse, angst, depression, skælven
English: • Severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins or cephalosporins).
Danish: • Svær overfølsomhed (f.eks. anafylaktisk reaktion, svær hudreaktion) over for andre beta-laktam antibakterielle lægemidler (f.eks. penicilliner eller cefalosporiner).
English: This medicine contains approximately 6.0 mEq (approximately 137 mg) of sodium per 1.0 g dose which should be taken into consideration by patients on a controlled sodium diet.
Danish: Dette lægemiddel indeholder ca. 6,0 mEq (ca. 137 mg) natrium per 1,0 g dosis, hvilket bør tages med i overvejelserne hos patienter, der er på natriumkontrolleret diæt.
English: 3 to 23 months 31/35 88.6 13/13 100.0
Danish: 3 - 23 måneder 31/35 2 - 12 år
English: In healthy young adults (25 to 45 years of age), the protein binding of ertapenem decreases, as plasma concentrations increase, from approximately 95 % bound at an approximate plasma concentration of < 50 micrograms/mL to approximately 92 % bound at an approximate plasma concentration of 155 micrograms/mL (average concentration achieved at the end of infusion following 1 g intravenously).
Danish: Hos raske, unge frivillige (25 - 45 år) falder ertapenems proteinbinding når plasmakoncentrationen stiger, fra ca. 95% binding ved en ca. plasmakoncentration på  50 mikrogram/ml til ca. 92% binding ved en ca. plasmakoncentration på 155 mikrogram/ml (gennemsnitlig koncentration nået ved afslutning af infusion af 1 g intravenøst).
English: Plasma concentrations of ertapenem are comparable in paediatric patients 13 to 17 years of age and adults following a 1 g once daily intravenous dose.
Danish: Ertapenem plasmakoncentrationer er sammenlignelige hos børn i alderen 13 - 17 år og voksne efter en dagligt intravenøs dosis på 1 g.
English: Sodium bicarbonate (E500); sodium hydroxide (E524) to adjust pH to 7.5.
Danish: Natriumhydrogencarbonat (E500); natriumhydroxid (E524) til at justere pH til 7,5.
English: • Hot flush, high blood pressure, red or purple, flat, pinhead spots under the skin
Danish: • Hedeture, forhøjet blodtryk, røde eller violette, flade pletter som knappenålshoveder under huden
English: Sodium bicarbonate (E500) Sodium hydroxide (E524) to adjust pH to 7.5
Danish: Natriumhydrogencarbonat (E500) Natriumhydroxid (E524) til justering af pH til 7,5
English: Ertapenem inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs).
Danish: Ertapenem hæmmer bakteriecellevægssyntesen efter binding til penicillinbindende proteiner (PBP'er).
English: • Dizziness, sleepiness, sleeplessness, confusion, seizure
Danish: • Svimmelhed, søvnighed, søvnløshed, forvirring, kramper
English: For prevention of surgical site infections following surgery of the colon or rectum, the recommended dose of INVANZ is 1 g administered as a single intravenous dose 1 hour before surgery.
Danish: Til forebyggelse af infektioner på operationssted efter operation af tyktarmen eller endetarmen er den anbefalede INVANZ dosis 1 g indgivet som en enkelt intravenøs dosis 1 time før operation.
English: Common: Decreases in neutrophil count Uncommon: Increases in platelet count, activated partial thromboplastin time, prothrombin time, decreases in haemoglobin
Danish: Almindelig: Fald i neutrofiltal Ikke almindelig: Forhøjet trombocyttal, øget aktiveret partiel tromboplastintid (APPT), forlænget protrombintid; fald i hæmoglobin
English: Prevention: • Prevention of surgical site infections in adults following surgery of the colon or rectum.
Danish: • Forebyggelse af infektioner på operationsstedet hos voksne efter operation af tyktarmen eller endetarmen.
English: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams.
Danish: Der er rapporteret alvorlige, og ind i mellem fatale, overfølsomhedsreaktioner (anafylaktiske reaktioner) hos patienter i behandling med beta-laktamer.
English: Uncommon: Hot flush, hypertension
Danish: Ikke almindelig: Hedeture, hypertension
English: The reconstituted solutions should be inspected visually for particulate matter and discolouration prior to administration, whenever the container permits.
Danish: Rekonstituerede opløsninger bør, i det omfang beholderen gør det muligt, efterses for partikler og misfarvning inden administration.
English: If you are concerned that you may have been given too much INVANZ, contact your doctor or another healthcare professional immediately.
Danish: Hvis De er bekymret for, om De har fået for meget INVANZ, skal De straks kontakte lægen eller sygeplejersken.
English: What INVANZ is and what it is used for What you need to know before you are given INVANZ How to use INVANZ
Danish: Oversigt over indlægssedlen Virkning og anvendelse Det skal De vide, før De får INVANZ Sådan skal INVANZ anvendes Bivirkninger
English: Therefore, no dosage adjustment is recommended in patients with hepatic impairment.
Danish: Det anbefales derfor ikke at justere dosis til patienter med leverinsufficiens.
English: Each vial contains 1.0 g ertapenem.
Danish: Hvert hætteglas indeholder 1,0 g ertapenem.
English: Lactobacillus species
Danish: Lactobacillus arter Andre:
English: What INVANZ contains
Danish: INVANZ indeholder:
English: • Changes in some laboratory blood tests
Danish: • Ændringer i visse laboratorieresultater af blodprøver
English: Adults 18 years of age and older:
Danish: Voksne (i alderen 18 år og ældre):
English: Common: Infusion site pain Uncommon: Infusion site burning, infusion site pruritus, infusion site erythema, injection site erythema, infusion site warmth
Danish: Almindelig: Smerte ved infusionsstedet Ikke almindelig: Brændende fornemmelse ved infusionsstedet, kløe ved infusionsstedet, erytem ved infusionsstedet, erytem ved injektionsstedet, varme ved infusionsstedet
English: Adults and adolescents (13 to 17 years of age): The dose of INVANZ is 1 gram (g) given once a day by the intravenous route (see section 6.6).
Danish: Voksne og unge (i alderen 13til 17 år): Dosis af INVANZ er 1 gram (g) givet 1 gang dagligt ved intravenøs administration (se pkt.
English: • Allergy, feeling unwell, pelvic peritonitis, changes to the white part of the eye, fainting.
Danish: • Allergi, utilpashed, underlivsbetændelse, ændringer af det hvide i øjnene, besvimelse.
English: Plasma concentrations at the midpoint of the dosing interval following a single 15 mg/kg intravenous dose of ertapenem in patients 3 months to 12 years of age are comparable to plasma concentrations at the midpoint of the dosing interval following a 1 g once daily intravenous dose in adults (see Plasma concentrations).
Danish: Plasmakoncentrationerne ved midtpunktet af doseringsintervallet efter en enkelt intravenøs dosis ertapenem på 15 mg/kg hos patienter i alderen 3 måneder - 12 år er sammenlignelig med plasmakoncentrationerne ved midtpunktet af doseringsintervallet efter en daglig intravenøs dosis på 1 g hos voksne (se Plasmakoncentrationer).
English: Side effects reported rarely (more than 1 in 10,000 patients and less than 1 in 1,000 patients) are:
Danish: Sjældne bivirkninger (forekommer hos mere end 1 ud af 10.000 patienter og færre end 1 ud af 1.000 patienter):
English: The most common (more than 1 in 100 patients and less than 1 in 10 patients) side effects are:
Danish: De mest almindelige bivirkninger (forekommer hos mere end 1 ud af 100 patienter og færre end 1 ud af 10 patienter):
English: In healthy young adults (18 to 49 years of age) and patients 13 to 17 years of age given a 1 g intravenous dose, the mean plasma half-life is approximately 4 hours.
Danish: Den gennemsnitlige halveringstid hos raske, unge voksne (18 - 49 år) og patienter i alderen 13 - 17 år administreret 1 g intravenøst er ca. 4 timer.
English: The efficacy of INVANZ in the treatment of community acquired pneumonia due to penicillin-resistant Streptococcus pneumoniae has not been established.
Danish: Der er ikke påvist effekt af INVANZ i behandling af samfundserhvervet pneumoni forårsaget af penicillinresistente Streptococcus pneumoniae.
English: • Burning, itching, redness and warmth at infusion site, redness at injection site
Danish: • Brænden, kløen, rødme og varme ved infusionsstedet, rødme ved indstiksstedet
English: Of evaluable patients treated with ertapenem in a clinical study for the treatment of intra-abdominal infections, in adults, 30 % had generalised peritonitis and 39 % had infections involving sites other than the appendix including the stomach, duodenum, small bowel, colon, and gallbladder; there were limited numbers of evaluable patients who were enrolled with APACHE II scores ≥ 15 and efficacy in these patients has not been established.
Danish: I et klinisk studie med behandling af intra-abdominale infektioner hos voksne havde 30% af de evaluerbare patienter, der var blevet behandlet med ertapenem, generaliseret peritonitis, og 39% havde infektioner, der involverede andre områder end appendiks, herunder mave, duodenum, tyndtarm, colon og galdeblære.
English: Common: Rash, pruritus Uncommon: Erythema, urticaria Rare: Dermatitis, desquamation Not known: Acute Generalised Exanthematous Pustulosis (AGEP), Drug Rash with Eosinophilia and Systemic Symptoms (DRESS syndrome)
Danish: Sjælden: Dermatitis, afskalning, Ikke kendt: Akut generaliseret eksantematøs pustulose (AGEP), lægemiddeludslæt med eosinofili og systemiske symptomer (DRESS syndrom)
English: There are inadequate data on the safety and efficacy of ertapenem in patients with advanced renal impairment and patients who require haemodialysis to support a dose recommendation.
Danish: Der foreligger ikke tilstrækkelige data vedrørende ertapenems sikkerhed og effekt hos patienter med fremskreden nedsat nyrefunktion og hos patienter, som er hæmodialysekrævende, til at understøtte en dosisrekommandation.
English: Common: Elevations in ALT, AST, alkaline phosphatase Uncommon: Increases in total serum bilirubin, direct serum bilirubin, indirect serum bilirubin, serum creatinine, serum urea, serum glucose
Danish: Almindelig: Stigninger i ALAT, ASAT, alkalisk fosfatase Ikke almindelig: Forhøjet total serumbilirubin, direkte serumbilirubin og indirekte serumbilirubin; serumkreatinin; serumurinstof, serumglucose Sjælden: Fald i serumhydrogencarbonat, serumkreatinin og serumkalium; forhøjet serum-LDH, serumfosfat og serumkalium
English: Uncommon: Dyspnoea, pharyngeal discomfort Rare: Nasal congestion, cough, epistaxis, rales/rhonchi, wheezing
Danish: Ikke almindelig: Dyspnø, faryngeale gener Sjælden: Tilstoppet næse, hoste, epistaxis, rallelyde/rhonchi, hvæsen
English: Uncommon: Increases in urine bacteria, urine white blood cells, urine epithelial cells, and urine red blood cells; urine yeast present Rare: Increase in urobilinogen
Danish: Ikke almindelig: Stigning i urinbakterier, hvide blodlegemer i urinen, epitelceller og røde blodlegemer i urinen; gærceller til stede i urinen
English: Common: Diarrhoea, nausea, vomiting
Danish: Almindelig: Diarré, kvalme, opkastning
English: • Diabetic foot infections of the skin and soft tissue (see section 4.4)
Danish: • Diabetesrelaterede infektioner i hud og bløddele på fødder (se pkt.
English: Uncommon: Anorexia Rare: Hypoglycaemia
Danish: Metabolisme og ernæring Ikke almindelig: Anoreksi Sjælden: Hypoglykæmi
English: Reconstituted solutions should be diluted in sodium chloride 9 mg/mL (0.9 %) solution immediately after preparation.
Danish: Rekonstituerede opløsninger skal fortyndes i natriumchlorid 9 mg/ml (0,9%) opløsning umiddelbart efter tilberedning.
English: Common: Elevations in ALT and AST
Danish: Almindelig: Forhøjet ALAT og ASAT
English: At the 15 mg/kg dose, the AUC value and plasma concentrations at the midpoint of the dosing interval in patients 3 months to 12 years of age were comparable to those in young healthy adults receiving a 1 g intravenous dose of ertapenem.
Danish: Ved dosis på 15 mg/kg var AUCværdien og plasmakoncentrationerne ved midtpunktet af doseringsintervallet hos patienter i alderen 3 måneder - 12 år sammenlignelig med værdierne hos unge raske voksne, der fik 1 g ertapenem intravenøst.
English: • Vaginal discharge and irritation
Danish: • Udflåd og irritation i skeden
English: • Diarrhoea, nausea, vomiting
Danish: • Diarré, kvalme, opkastning
English: Infants and children (3 months to 12 years of age): The dose of INVANZ is 15 mg/kg given twice daily (not to exceed 1 g/day) by the intravenous route (see section 6.6).
Danish: Spædbørn og børn (i alderen 3 måneder til 12 år): Dosis af INVANZ er 15 mg/kg to gange dagligt (må ikke overstige 1 g/dag) ved intravenøs administration (se pkt.
English: • Changes in white blood cell count
Danish: • Ændringer i antallet af hvide blodlegemer
English: Following a single 1 g intravenous dose of ertapenem in adults, AUCs of total ertapenem (bound and unbound) and of unbound ertapenem are similar in patients with mild renal impairment (Clcr 60 to 90 mL/min/1.73 m2) compared with healthy subjects (ages 25 to 82 years).
Danish: Efter enkelt, intravenøs dosis af ertapenem 1 g hos voksne, er AUC af ertapenem totalt (bundet og ubundet) og af ubundet ertapenem, ens hos patienter med let nedsat nyrefunktion (Clcr 6090 ml/min/1,73 m2) og hos raske frivillige (25 - 82 år).