FrancophonIA/ELRC3.0 huggingface dataset:
English: • 5 to 10 mg orally, repeated after 12 hours if necessary to a maximum of 20 mg/day.
Slovenian: • 5 do 10 mg peroralno in ponovitev odmerjanja po 12 urah, če je potrebno, do največ 20 mg na dan.
English: Your doctor will also tell you whether to take Haldol one or more times a day.
Slovenian: Povedal vam bo tudi, ali morate jemati zdravilo Haldol enkrat, dvakrat ali večkrat na dan.
English: These include mental health problems (such as schizophrenia and bipolar disorder) and behavioural problems.
Slovenian: To vključuje duševne motnje (kot sta shizofrenija in bipolarna motnja) ter vedenjske motnje.
English: If antipsychotics are withdrawn, recurrence of symptoms related to the underlying condition may not become apparent for several weeks or months.
Slovenian: V primeru odtegnitve antipsihotikov se ponovitev simptomov osnovne bolezni lahko pokaže šele po več tednih ali mesecih.
English: The syndrome may be masked when treatment is reinstituted, when the dose is increased or when a switch is made to a different antipsychotic.
Slovenian: Sindrom se lahko prikrije pri ponovni uvedbi zdravljenja, pri zvečevanju odmerka ali pri prehodu na drug antipsihotik.
English: • Close the bottle, then rinse the oral syringe with some water.
Slovenian: • Zaprite steklenico in izperite peroralno brizgo z malo vode.
English: In schizophrenia, the response to antipsychotic treatment may be delayed.
Slovenian: Pri shizofreniji lahko pride do zakasnelega odziva na zdravljenje z antipsihotiki.
English: Switch from mania to depression
Slovenian: Prehod iz maničnega v depresivno stanje
English: The extent to which this association is attributable to the medicinal product, as opposed to being confounded by patient characteristics, has not yet been elucidated.
Slovenian: V kolikšni meri je to povezanost mogoče pripisati samemu zdravilu in v kolikšni meri nanjo vplivajo lastnosti bolnika, še ni bilo pojasnjeno.
English: • Feel very excited, agitated, enthusiastic, impulsive or hyperactive
Slovenian: • ste lahko zelo vznemirjeni, nemirni (agitirani), navdušeni, impulzivni ali hiperaktivni,
English: The recommended initial haloperidol dose in elderly patients is half the lowest adult dose.
Slovenian: Priporočeni začetni odmerek haloperidola pri starejših bolnikih je polovica najmanjšega odmerka za odrasle.
English: Fertility - Haldol may increase your levels of a hormone called ‘prolactin', which may affect fertility in men and women.
Slovenian: Plodnost - Zdravilo Haldol lahko povzroči zvišanje ravni hormona, ki ga imenujemo »prolaktin«, kar lahko vpliva na plodnost pri moških in ženskah.
English: In adolescents and children, Haldol is used to treat schizophrenia in patients aged 13 to 17 years, and to treat behavioural problems in patients aged 6 to 17 years.
Slovenian: Pri mladostnikih in otrocih zdravilo Haldol uporabljamo za zdravljenje shizofrenije pri bolnikih, starih od 13 do 17 let, in vedenjskih motenj pri bolnikih, starih od 6 do 17 let.
English: Your doctor will tell you how many tablets to take and for how long.
Slovenian: Zdravnik vam bo povedal, koliko tablet morate jemati in kako dolgo.
English: How much should you take
Slovenian: Koliko zdravila jemati
English: • High level of ‘antidiuretic hormone' in the blood (syndrome of inappropriate antidiuretic hormone secretion)
Slovenian: • zvišana raven antidiuretskega hormona v krvi (sindrom neustreznega izločanja antidiuretskega hormona)
English: It is a potent central dopamine type 2 receptor antagonist, and at recommended doses, has low alpha-1 antiadrenergic activity and no antihistaminergic or anticholinergic activity.
Slovenian: Je močan antagonist centralnih dopaminskih receptorjev tipa 2, v priporočenih odmerkih deluje v manjši meri tudi alfa-1 adrenergično, pri tem pa ne deluje antihistaminergično ali antiholinergično.
English: • Epilepsy or have ever had fits (convulsions)
Slovenian: • če imate epilepsijo ali ste imeli že kdaj prej napade krčev (konvulzije)
English: • Inflamed small blood vessels, leading to a skin rash with small red or purple bumps
Slovenian: • vnetje malih krvnih žil, ki povzroči kožni izpuščaj z majhnimi rdečimi ali vijoličnimi bulicami
English: • Depression, or you have bipolar disorder and start to feel depressed.
Slovenian: • če imate depresijo ali bipolarno motnjo in čutite, da postajate depresivni
English: Haloperidol is an antipsychotic belonging to the butyrophenones group.
Slovenian: Haloperidol je antipsihotik iz skupine butirofenonov.
English: • Gently press the sides of the bottle and count the number of drops you need to take.
Slovenian: • Nežno stiskajte vsebnik z obeh strani in štejte kapljice, ki jih morate odmeriti.
English: • A swollen face, lips, mouth, tongue or throat
Slovenian: • otekanje obraza, ustnic, ust, jezika ali grla oziroma žrela
English: • In adults to help control movements in Huntington's disease.
Slovenian: • pri odraslih za obvladovanje zgibkov pri Huntingtonovi bolezni.
English: For instructions on handling HALDOL solution for injection, see section 6.6.
Slovenian: Za navodila za ravnanje z zdravilom HALDOL raztopina za injiciranje glejte poglavje 6.6.
English: However, there have been isolated case reports of birth defects following foetal exposure to haloperidol, mostly in combination with other medicinal products.
Slovenian: Poročali pa so o posameznih primerih prirojenih okvar po izpostavljenosti ploda haloperidolu, večinoma v kombinaciji z drugimi zdravili.
English: • Swallow the tablets with some water.
Slovenian: • Tablete je treba pogoltniti z vodo.
English: A low initial dose is recommended, which subsequently may be adjusted according to the patient's response.
Slovenian: Priporočljiv je majhen začetni odmerek, ki ga je kasneje mogoče prilagajati glede na bolnikov odziv.
English: Treatment response and withdrawal
Slovenian: Odziv na zdravljenje in odtegnitev
English: • Uncorrected hypokalaemia.
Slovenian: • neodpravljena hipokaliemija
English: Your doctor may want to check the levels of potassium or magnesium (or other ‘electrolyte') in your blood before or during your treatment with Haldol.
Slovenian: Zdravnik bo verjetno želel preverjati ravni kalija ali magnezija (ali drugih elektrolitov) v vaši krvi pred ali med zdravljenjem z zdravilom Haldol.
English: The use of haloperidol has been associated with the development of akathisia, characterised by a subjectively unpleasant or distressing restlessness and need to move, often accompanied by an inability to sit or stand still.
Slovenian: Uporabo haloperidola povezujejo z razvojem akatizije, za katero sta značilna neprijeten ali mučen subjektiven občutek nemira in potreba po gibanju, ki ju pogosto spremlja nezmožnost mirnega sedenja ali stanja.
English: In 2 studies in children receiving haloperidol treatment for tics and Tourette's syndrome, a positive response was associated with plasma concentrations of 1 to 4 ng/ml
Slovenian: V 2 študijah pri bolnikih, ki so prejemali haloperidol za zdravljenje tikov in Tourettovega sindroma, je bil pozitiven odgovor povezan s plazemskimi koncentracijami od 1 do 4 ng/ml.
English: This product information is the outcome of the referral procedure to which this Commission decision relates.
Slovenian: Opomba: Te informacije o zdravilu so rezultat odločbe Komisije v napotitvenem postopku.
English: It is recommended that patients who take haloperidol concomitantly with such medicinal products be monitored for signs or symptoms of increased or prolonged pharmacologic effects of haloperidol, and the HALDOL dose be decreased as deemed necessary.
Slovenian: Bolnike, ki jemljejo haloperidol sočasno s takimi zdravili, je priporočljivo spremljati in biti pozoren na znake oziroma simptome izrazitejšega ali podaljšanega farmakološkega delovanja haloperidola ter po potrebi zmanjšati odmerek zdravila HALDOL.
English: Patients must always be maintained on the minimal effective dose (see section 5.2).
Slovenian: Pri vzdrževalnem zdravljenju morajo bolniki vedno prejemati najmanjši še učinkovit odmerek (glejte poglavje 5.2).
English: • The highest dose elderly people should take is 5 mg each day unless your doctor decides a higher dose is needed.
Slovenian: • Največji odmerek, ki ga smejo uporabljati starejše osebe, je 5 mg vsak dan, razen če zdravnik odloči, da je potreben večji odmerek.
English: Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with HALDOL and preventive measures undertaken.
Slovenian: Ker so pri bolnikih, ki prejemajo antipsihotike, pogosto prisotni pridobljeni dejavniki tveganja za razvoj VTE, je treba pred in med zdravljenjem z zdravilom HALDOL ugotavljati prisotnost vseh možnih dejavnikov tveganja za razvoj VTE in uvesti preventivne ukrepe.
English: Patients with first-episode schizophrenia generally respond to 2 to 4 mg/day, whereas patients with multiple-episode schizophrenia may need doses up to 10 mg /day.
Slovenian: Bolniki s prvo epizodo shizofrenije se praviloma dobro odzovejo na odmerek 2 do 4 mg na dan, bolniki, ki so imeli že več epizod shizofrenije, pa lahko potrebujejo odmerke do 10 mg na dan.
English: Tell your doctor straight away and stop taking both medicines if you get:
Slovenian: Takoj obvestite zdravnika in prenehajte jemati obe zdravili, če opazite:
English: Adverse reaction frequencies are based on (or estimated from) clinical trials or epidemiology studies with haloperidol, and classified using the following convention:
Slovenian: Pogostnosti neželenih učinkov izhajajo iz (oziroma so ocenjene na osnovi) podatkov kliničnih ali epidemioloških študij s haloperidolom in so razvrščene po naslednjem dogovoru:
English: Nonetheless, it is advised that in patients who are treated concomitantly with lithium and HALDOL, therapy must be stopped immediately if such symptoms occur.
Slovenian: Ne glede na to je pri bolnikih, ki sočasno prejemajo litij in zdravilo HALDOL, priporočljivo takoj prekiniti zdravljenje, če se pojavijo tovrstni simptomi.
English: HALDOL oral solution should be used for single doses of less than 1 mg that cannot be achieved with HALDOL tablets.
Slovenian: Peroralna raztopina zdravila HALDOL se uporablja za odmerjanje posameznih odmerkov, ki so manjši od 1 mg in jih ni mogoče odmerjati s tabletami zdravila HALDOL.
English: The average bioavailability of haloperidol after administration of the tablet or oral solution is 60 to 70%.
Slovenian: Povprečna biološka uporabnost haloperidola po odmerjanju s tabletami ali peroralno raztopino je 60% do 70%.
English: It may be mixed with water to facilitate dose administration, but it must not be mixed with any other liquid.
Slovenian: Za lažje uživanje je raztopino mogoče zmešati z vodo, ne sme pa se je mešati z nobeno drugo tekočino.
English: • A high level of the hormone 'prolactin' in your blood, or cancer that may be caused by high prolactin levels (such as breast cancer)
Slovenian: • če imate zvišano raven hormona »prolaktina« v krvi ali če imate raka, ki ga lahko povzroča previsoka raven prolaktina (kot je rak dojke)
English: • Effects on blood cells - low number of all types of blood cells, including severe decreases in white blood cells and low number of ‘platelets' (cells that help blood to clot)
Slovenian: • učinki na krvne celice - zmanjšano število vseh vrst krvnih celic, vključno s hudim zmanjšanjem števila levkocitov in zmanjšanim številom trombocitov (krvnih ploščic, ki omogočajo strjevanje krvi) • občutek zmedenosti
English: Table 4: Haloperidol dose recommendations for paediatric population
Slovenian: Preglednica 4: Priporočila za odmerjanje haloperidola za pediatrično populacijo
English: • Depression (‘tricyclic antidepressants')
Slovenian: • za zdravljenje depresije (»triciklične antidepresive«)
English: If signs and symptoms of tardive dyskinesia appear, the discontinuation of all antipsychotics, including HALDOL, must be considered.
Slovenian: Če se pojavijo znaki in simptomi tardivne diskinezije, je treba pri bolniku razmisliti o ukinitvi vseh antipsihotikov, vključno z zdravilom HALDOL.
English: • Problems breathing or feeding.
Slovenian: • težave z dihanjem ali motnje hranjenja.
English: Available safety data in the paediatric population indicate a risk of developing extrapyramidal symptoms, including tardive dyskinesia, and sedation.
Slovenian: Pediatrična populacija Varnostni podatki, ki so na voljo za pediatrično populacijo, kažejo, da obstaja tveganje za razvoj ekstrapiramidnih simptomov, vključno s tardivno diskinezijo, in za sedacijo.
English: • You may be given extra doses, normally 1 to 4 hours apart.
Slovenian: • Morda boste prejeli še nadaljnje odmerke, praviloma z 1 do 4-urnimi presledki.
English: Other medicines and Haldol
Slovenian: Druga zdravila in zdravilo Haldol
English: • In the majority of patients, doses of up to 15 mg/day are sufficient.
Slovenian: • Pri večini bolnikov zadošča odmerek do 15 mg na dan.
English: • Adolescents up to 17 years of age being treated for schizophrenia or behavioural problems may have a higher dose, up to 5 mg each day.
Slovenian: • Mladostniki, stari do 17 let, ki se zdravijo zaradi shizofrenije ali vedenjskih motenj, lahko prejemajo večje odmerke, in sicer do 5 mg vsak dan.
English: Haldol can cause problems with the heart, problems controlling body or limb movements and a serious side effect called ‘neuroleptic malignant syndrome'.
Slovenian: Zdravilo Haldol lahko povzroča težave z delovanjem srca, z nadzorovanjem premikanja trupa ali okončin in resen neželeni učinek, ki ga imenujemo »nevroleptični maligni sindrom«.
English: • Doses above 10 mg/day have not demonstrated superior efficacy to lower doses in the majority of patients and may cause an increased incidence of extrapyramidal symptoms.
Slovenian: • Odmerki nad 10 mg na dan pri večini bolnikov niso bili bolj učinkoviti od manjših odmerkov, lahko pa povečajo pojavnost ekstrapiramidnih simptomov.
English: Increased haloperidol plasma concentrations may result in an increased risk of adverse events, including QTc-prolongation (see section 4.4).
Slovenian: Zvišana koncentracija haloperidola v plazmi lahko poveča tveganje za neželene učinke, vključno s podaljšanjem intervala QTc (glejte poglavje 4.4).
English: • Lowering blood pressure (such as guanethidine and methyldopa)
Slovenian: • za zniževanje krvnega tlaka (kot sta gvanetidin in metildopa)
English: Limited plasma concentration data were established in paediatric studies including 78 patients with various disorders (schizophrenia, psychotic disorder, Tourette's syndrome, autism) who received oral haloperidol doses up to a maximum of 30 mg/day.
Slovenian: Manjše število podatkov o koncentracijah v plazmi so pridobili v pediatričnih študijah, v katere je bilo vključenih 78 bolnikov z različnimi boleznimi (shizofrenija, psihotična motnja, Tourettov sindrom, avtizem), ki so prejemali haloperidol peroralno v odmerkih do največ 30 mg na dan.
English: • Elderly people will normally start on 0.5 mg each day or half the lowest adult dose.
Slovenian: • Starejši ljudje običajno začnejo zdravljenje z odmerkom 0,5 mg vsak dan oziroma s polovico najmanjšega odmerka za odrasle.
English: A subset of patients may require higher concentrations as a consequence of a high inter-subject variability in haloperidol pharmacokinetics.
Slovenian: Pri manjšem delu bolnikov so lahko potrebne višje koncentracije zaradi velike interindividualne variabilnosti farmakokinetike haloperidola.
English: Certain medicines may affect the way that Haldol works or may make heart problems more likely
Slovenian: Določena zdravila lahko vplivajo na delovanje zdravila Haldol ali povečajo verjetnost za težave s srcem
English: telithromycin).
Slovenian: telitromicin),
English: HALDOL tablets are for oral use.
Slovenian: HALDOL tablete so namenjene za peroralno uporabo.
English: Austria, Belgium, Cyprus, France, Italy, Luxembourg, Netherlands, Portugal, Sweden, United Kingdom:
Slovenian: Avstrija, Belgija, Ciper, Francija, Italija, Luksemburg, Nizozemska, Portugalska, Švedska, Velika Britanija:
English: The haloperidol dose may be adjusted according to the patient's response.
Slovenian: Odmerek haloperidola je mogoče prilagajati glede na odziv pri bolniku.
English: Doses above 5 mg/day should only be considered in patients who have tolerated higher doses and after reassessment of the patient's individual benefit-risk profile.
Slovenian: O odmerkih, večjih od 5 mg/dan, lahko razmislite samo pri bolnikih, ki so prenašali večje odmerke in po ponovni oceni razmerja med koristmi in tveganjem za bolnika.
English: • The continued use of HALDOL should be evaluated early in treatment (see section 4.4).
Slovenian: • Smiselnost nadaljevanja zdravljenja z zdravilom HALDOL je treba oceniti zgodaj v poteku zdravljenja (glejte poglavje 4.4).
English: • Serious mental health problem, such as believing things that are not true (delusions) or seeing, feeling, hearing or smelling things that are not there (hallucinations)
Slovenian: • resne duševne motnje, kot so prepričanje v stvari, ki niso resnične (blodnje) ali zmotno zaznavanje: bolnik vidi, tipa, sliši ali voha stvari, ki ne obstajajo (halucinacije)
English: • To prevent or treat nausea and vomiting (feeling and being sick) after surgery.
Slovenian: • za preprečevanje ali zdravljenje občutka slabosti (navzee) in bruhanja po operaciji.
English: In addition, the safety of haloperidol decanoate was evaluated in 410 patients who participated in 3 comparator studies (1 comparing haloperidol decanoate versus fluphenazine and 2 comparing the decanoate formulation to oral haloperidol), 9 open label studies and 1 dose response study.
Slovenian: Dodatno so varnost haloperidildekanoata ocenjevali pri 410 bolnikih, ki so bili vključeni v katero izmed 3 primerjalnih študij (v eni so primerjali haloperidildekanoat s flufenazinom, v dveh pa so primerjali formulacijo dekanoata s peroralno formulacijo haloperidola), v katero izmed 9 odprtih študij ali v študijo odziva na velikost odmerka.
English: Haldol is also used:
Slovenian: Zdravilo Haldol uporabljamo tudi:
English: • You can mix Haldol oral solution in some water before you take it, but don't mix it with any other liquids.
Slovenian: • Peroralno raztopino zdravila Haldol lahko pred zaužitjem zmešate z vodo, ne smete pa je mešati z nobeno drugo tekočino.
English: What Haldol contains
Slovenian: Zdravilo Haldol vsebuje
English: • Elderly people will normally start on half the lowest adult dose.
Slovenian: • Starejši ljudje običajno začnejo zdravljenje s polovico najmanjšega odmerka za odrasle.
English: • Drink the solution straight away.
Slovenian: • Raztopino takoj popijte.
English: • Low body temperature.
Slovenian: • znižana telesna temperatura
English: • Treatment of persistent aggression and psychotic symptoms in patients with moderate to severe
Slovenian: • zdravljenje persistentne agresivnosti in psihotičnih simptomov pri bolnikih z zmerno do hudo
English: • Calming you down or helping you to sleep (tranquillisers)
Slovenian: • za umiritev (pomirjevala) ali uspavanje (uspavala)
English: Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death.
Slovenian: Pri starejših bolnikih, ki imajo katero od psihoz v povezavi z demenco in prejemajo antipsihotike, obstaja povečano tveganje za smrt.
English: • You will not be given more than a total of 5 mg each day unless your doctor decides a higher dose is needed.
Slovenian: • V enem dnevu boste skupno prejeli največ 5 mg razen, če zdravnik odloči, da je potreben večji odmerek.
English: In cases of severe extrapyramidal reactions, parenteral administration of an antiparkinson medicinal product is recommended.
Slovenian: V primeru hudih ekstrapiramidnih reakcij je priporočljivo parenteralno odmerjanje antiparkinsonikov.
English: • May be repeated hourly until sufficient symptom control is achieved.
Slovenian: • Odmerjanje je mogoče ponavljati na eno uro do ustrezne umiritve simptomov.
English: Haldol is used in adults, adolescents and children for illnesses affecting the way you think, feel or behave.
Slovenian: Zdravilo Haldol uporabljamo pri odraslih, mladostnikih in otrocih za zdravljenje bolezni, ki vplivajo na mišljenje, občutenje ali vedenje.
English: • The highest dose adults should take depends on the condition you are being treated for and varies between 5 mg and 20 mg each day.
Slovenian: • Največji odmerek, ki ga smejo uporabljati odrasli, je odvisen od bolezni, zaradi katere se zdravite, in je lahko od 5 do 20 mg vsak dan.
English: • Empty the contents of the oral syringe onto a spoon or into a cup.
Slovenian: • Vsebino peroralne brizge iztisnite na žlico ali v skodelico.
English: Further doses may be administered and adjusted according to the patient's response.
Slovenian: Nadaljnje odmerke je mogoče odmerjati in prilagajati glede na odziv pri bolniku.
English: Haloperidol apparent clearance after extravascular administration ranges from 0.9 to 1.5 l/h/kg and is reduced in poor metabolisers of CYP2D6.
Slovenian: Navidezni očistek haloperidola po ekstravaskularnem odmerku znaša od 0,9 do 1,5 l/h/kg, manjši pa je pri slabih presnavljalcih s CYP2D6.
English: • The maximum dose is 15 mg/day because safety concerns outweigh the clinical benefits of treatment at higher doses.
Slovenian: • Največji odmerek je15 mg na dan, saj varnostni pomisleki presegajo koristi zdravljenja z večjimi odmerki.
English: As a precautionary measure, it is preferable to avoid the use of HALDOL during pregnancy.
Slovenian: Iz previdnosti se je v času nosečnosti bolje izogibati uporabi zdravila HALDOL.
English: Treatment with HALDOL solution for injection must be discontinued as soon as clinically indicated and, if further treatment is needed, oral haloperidol should be initiated at a 1:1 dose conversion rate followed by dose adjustment according to clinical response.
Slovenian: Zdravljenje z raztopino za injiciranje HALDOL je treba prekiniti takoj, ko je to klinično indicirano, in če je potrebno nadaljnje zdravljenje, uvesti peroralni haloperidol z začetno pretvorbo odmerjanja 1:1 in odmerek prilagoditi glede na klinični odziv.
English: Your dose of haloperidol will depend on:
Slovenian: Odmerek haloperidola, ki ga boste prejemali, je odvisen od:
English: Acute dystonia may occur during the first few days of treatment with HALDOL, but later onset as well as onset after dose increases has been reported.
Slovenian: Akutna distonija se lahko pojavi v prvih nekaj dneh zdravljenja z zdravilom HALDOL, poročali pa so tudi o pojavljanju kasneje v poteku zdravljenja in po zvečevanju odmerka.
English: • High body temperature
Slovenian: • zvišana telesna temperatura
English: The risk of QTc prolongation increases with haloperidol dose and with haloperidol plasma concentrations.
Slovenian: Tveganje za podaljšanje intervala QTc se povečuje z velikostjo odmerka haloperidola in koncentracijo haloperidola v plazmi.
English: Due to the high inter-subject variability in haloperidol pharmacokinetics and the concentration-effect relationship, it is recommended to adjust the individual haloperidol dose based on the patient's response, taking into account data suggesting a lag time of 5 days to reach half of the maximal therapeutic response.
Slovenian: Zaradi velike interindividualne variabilnosti farmakokinetike haloperidola in zaradi odvisnosti učinka od koncentracije haloperidola je priporočljivo odmerjanje prilagoditi posameznemu bolniku glede na bolnikov odziv in pri tem upoštevati podatke o intervalu 5 dni, ki je potreben za doseganje polovične ravni največjega terapevtskega odziva.
English: There have been very rare reports of acute withdrawal symptoms (including nausea, vomiting and insomnia) after abrupt withdrawal of high doses of antipsychotics.
Slovenian: O akutnih odtegnitvenih simptomih (med drugim o navzei, bruhanju in nespečnosti) po nenadni odtegnitvi velikih odmerkov antipsihotikov so poročali zelo redko.
English: The maximum dose in elderly patients is 5 mg/day.
Slovenian: Največji odmerek pri starejših bolnikih je 5 mg na dan.
English: The terminal elimination half-life of haloperidol is on average 21 hours (range 13 to 36 hours) after intramuscular administration.
Slovenian: Končni razpolovni čas izločanja haloperidola po intramuskularnem odmerku je v povprečju 21 ur (od 13 do 36 ur).