FrancophonIA/ELRC3.0 huggingface dataset:
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Danish: • når risikostyringssystemet ændres, særlig som følge af, at der er modtaget nye oplysninger, der kan medføre en væsentlig ændring i risk/benefit-forholdet, eller som følge af, at en vigtig milepæl (lægemiddelovervågning eller risikominimering) er nået
English: Always take these capsules exactly as your doctor has told you.
Danish: Brug altid disse kapsler nøjagtigt efter lægens anvisning.
English: Make sure that you take this leaflet and any remaining capsules with you to show to the doctor.
Danish: Husk at medbringe denne indlægsseddel og resten af kapslerne for at vise dem til lægen.
English: You should leave at least 2 hours between taking Feraccru and taking:
Danish: Der bør være et mellemrum på mindst 2 timer mellem indtagelse af Feraccru og indtagelse af:
English: The recommended dose is one capsule (30 mg) taken twice a day, morning and evening.
Danish: Den anbefalede dosis er én kapsel (30 mg) to gange dagligt, morgen og aften.
English: Do not pass it onto others.
Danish: Lad derfor være med at give medicinen til andre.
English: If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Danish: Hvis du er gravid eller ammer, har mistanke om, at du er gravid, eller planlægger at blive gravid, skal du spørge din læge eller apotekspersonalet til råds, før du bruger dette lægemiddel.
English: TSAT and total serum iron profiles were comparable between Day 1 and Day 8.
Danish: Profilerne af TSAT og totalt serumjern var sammenlignelige på dag 1 og dag 8.
English: The median (min-max) time since last disease flare was around 7 months (0.0-450 months).
Danish: Mediantiden (min-max) siden sidste eksacerbation af sygdommen var omkring 7 måneder (0,0-450 måneder).
English: The pharmacokinetic profiles of maltol/maltol glucuronide and iron parameters were independent of one another.
Danish: De farmakokinetiske profiler af maltol/maltolglucuronid og jernparametre var uafhængige af hinanden.
English: Small intestinal bacterial overgrowth
Danish: Lille intestinal overvækst Opkastning
English: Patheon France 40 boulevard de champaret 38300 Bourgoin-Jallieu FRANCE
Danish: Patheon France 40 boulevard de champaret 38300 Bourgoin-Jallieu Frankrig
English: Take Feraccru on an empty stomach with half a glass of water (one hour before a meal, or at least 2 hours after a meal).
Danish: Tag Feraccru på tom mave med et halvt glas vand (en time før et måltid eller mindst to timer efter et måltid).
English: Call your doctor or hospital straightaway if you or another person has taken too much Feraccru.
Danish: Søg straks lægehjælp eller skadestue, hvis du eller en anden har taget for meget Feraccru.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA < PC: {number}
Danish: ENTYDIG IDENTIFIKATOR - MENNESKELIGT LÆSBARE DATA PC: {nummer}
English: In serious cases there can be recurrence of vomiting and gastrointestinal bleeding, 12 hours after ingestion.
Danish: I alvorlige tilfælde kan der forekomme gentagne opkastninger og gastrointestinal blødning 12 timer efter indtagelsen.
English: Adverse reaction frequencies are defined as: very common (≥1/10), common (≥1/100, <1/10), uncommon (≥1/1,000, <1/100), rare (≥1/10,000, <1/1,000) or very rare (<1/10000).
Danish: Hyppigheden af bivirkninger er defineret som: meget almindelig (≥1/10), almindelig (≥1/100, <1/10), ikke almindelig (≥1/1,000, <1/100), sjælden (≥1/10 000, <1/1 000) eller meget sjælden (<1/10 000).
English: Patients were enrolled in one combined randomised, placebo-controlled clinical study (AEGIS 1/2).
Danish: Patienterne blev indrulleret i én kombineret, randomiseret, placebokontrolleret klinisk undersøgelse (AEGIS 1/2).
English: Too much iron is dangerous in young children and can be life-threatening.
Danish: For meget jern er farligt for små børn og kan være livstruende.
English: • Patients receiving repeated blood transfusions.
Danish: • Gentagne blodtransfusioner.
English: Do not take Feraccru: - If you are allergic to ferric maltol or any of the other ingredients of this medicine (listed in section 6).
Danish: Tag ikke Feraccru: - hvis du er allergisk over for ferrimaltol eller et af de øvrige indholdsstoffer i dette lægemiddel (angivet i afsnit 6).
English: Acne Erythema
Danish: Acne Erytem
English: Administration of iron preparations and tetracyclines should be separated by 2 to 3 hours.
Danish: Administration af jernpræparater og tetracykliner bør være adskilt af 2-3 timer.
English: Ingestion of 20 mg/kg elemental iron is potentially toxic and 200-250 mg/kg is potentially fatal.
Danish: Indtagelse af 20 mg jern/kg er potentielt toksisk, og 200-250 mg/kg er potentielt dødeligt.
English: Red capsule (19 mm long x 7 mm diameter).
Danish: Røde kapsler (længde 19 mm x diameter 7 mm)
English: 4.5 Interaction with other medicinal products and other forms of interaction No drug interaction studies have been performed with Feraccru.
Danish: 4.5 Interaktion med andre lægemidler og andre former for interaktion Der er ikke udført interaktionsstudier med Feraccru.
English: The PRAC concluded that the product information of products containing ferric maltol should be amended accordingly.
Danish: PRAC konkluderede, at produktinformationen for produkter indeholdende ferrimaltol bør ændres i overensstemmelse hermed.
English: Blood tests may show increased levels of proteins that break down chemicals in the blood and of a hormone that stimulates the thyroid gland.
Danish: Blodprøver kan vise øget indhold af proteiner, der nedbryder kemikalier i blodet, og af et hormon, der stimulerer skjoldbruskkirtlen.
English: • Some antibiotics, such as ciprofloxacin and tetracycline.
Danish: • visse antibiotika såsom ciprofloxacin og tetracyklin
English: • Crospovidone (Type A)
Danish: • Crospovidon (Type A)
English: There are no data from the use of Feraccru in pregnant women.
Danish: Der foreligger ingen data fra anvendelse af Feraccru hos gravide kvinder.
English: Intravenous administration of iron salts
Danish: 4.2) Intravenøs administration af jernsalte
English: Iron preparations in excess may cause toxicity especially among children.
Danish: Overdosering med jernpræparater kan medføre toksicitet, specielt hos børn.
English: No data are available (see section 4.4).
Danish: Der foreligger ingen data (se pkt.
English: Symptoms of iron overdose
Danish: Symptomer på overdosering med jern
English: Abdominal pain (including upper abdomen) Flatulence
Danish: Abdominalsmerter (også i øvre abdomen)
English: • Sodium laurilsulfate
Danish: • Natriumlaurilsulfat
English: 83 % of the patients with CD had a CDAI-score <150 and 17 % a CDAI-score >150-220.
Danish: 83 % af patienterne med Crohns sygdom havde en CDAI-score <150, og 17 % en CDAI-score >150-220.
English: Before starting treatment, your doctor will use a blood test to make sure that your anaemia is not severe or caused by anything other than iron deficiency (low iron stores).
Danish: Før du påbegynder behandlingen, vil lægen tage en blodprøve for at sikre, at din anæmi ikke er svær eller skyldes andet end jernmangel (lavt jernindhold i jerndepoterne).
English: These medicinal products should be given at least 2 hours apart from Feraccru.
Danish: Disse lægemidler bør gives mindst 2 timer før eller efter Feraccru.
English: In mild cases early features improve but in more serious cases there may be evidence of hypoperfusion (cool peripheries and hypotension), metabolic acidosis and systemic toxicity.
Danish: I lette tilfælde indtræder der bedring i de tidlige symptomer, mens der i mere alvorlige tilfælde kan være tegn på hypoperfusion (kolde periferier og hypotension), metabolisk acidose og systemisk toksicitet.
English: The most common side effects (may affect up to 1 in 10 people) of Feraccru are:
Danish: De almindeligste bivirkninger (forekommer hos indtil 1 ud af 10 personer) er:
English: SPECIAL STORAGE CONDITIONS Store below 25°C.
Danish: SÆRLIGE OPBEVARINGSBETINGELSER Opbevares ved temperaturer under 25 C.
English: No dose adjustment is needed in elderly patients
Danish: Der behøves ingen dosisjustering hos ældre.
English: Pharmacotherapeutic group: Iron trivalent, oral preparation, ATC code: B03AB10.
Danish: Farmakoterapeutisk klassifikation: Jern(III)-præparater, orale, ATC-kode: B03AB10.
English: The recommended dose is one capsule twice daily, morning and evening, on an empty stomach (see section 4.5).
Danish: Den anbefalede dosis er én kapsel to gange dagligt, morgen og aften, på tom mave (se pkt.
English: The difference between the change from baseline for Feraccru compared to placebo at week 12 was 2.25 g/dL (p<0.0001).
Danish: Forskellen mellem ændringen fra baseline for Feraccru og placebo ved uge 12 var 2,25 g/dl (p<0,0001).
English: EXP: Use within 45 days of first opening.
Danish: EXP: Anvendes senest 45 dage efter anbrud.
English: The use of desferroxamine should be considered: for detailed information see product information provided by the manufacturer.
Danish: Brug af deferoxamin bør overvejes - læs produktinformationen fra fremstilleren for at få nærmere oplysninger herom.
English: Low iron causes anaemia (too few red blood cells).
Danish: Lavt indhold af jern medfører for få røde blodlegemer (anæmi).
English: Feraccru is available in bottles, each containing 56 capsules.
Danish: Feraccru fås i flasker, der indeholder 56 kapsler.
English: Taking into account the PRAC Assessment Report on the PSUR(s) for ferric maltol, the scientific conclusions of CHMP are as follows:
Danish: Under hensyntagen til PRAC's vurderingsrapport om PSUR'en/PSUR'erne for ferrimaltol er CHMP nået frem til følgende videnskabelige konklusioner:
English: The complex dissociates on uptake from the gastro-intestinal tract and the complex itself does not enter the systemic circulation.
Danish: Komplekset dissocierer ved optagelsen fra mave-tarmkanalen, og komplekset selv træder ikke ind i det systemiske kredsløb.
English: • Mycophenolate (used with other medicines to prevent the body rejecting transplanted organs).
Danish: • mycophenolat (anvendes sammen med andre lægemidler til at forhindre afstødning af transplanterede organer)
English: • Penicillamine (used to bind metals).
Danish: • penicillamin (anvendes til at binde metaller)
English: UNCOMMON (≥ 1/1000 to < 1/100)
Danish: IKKE ALMINDELIG (≥ 1/1.000 til < 1/100)
English: PHARMACEUTICAL FORM AND CONTENTS 56 capsules METHOD AND ROUTE(S) OF ADMINISTRATION Oral use.
Danish: LÆGEMIDDELFORM OG INDHOLD (PAKNINGSSTØRRELSE) 56 kapsler ANVENDELSESMÅDE OG ADMINISTRATIONSVEJ(E) Oral anvendelse.
English: Northumberland NE61 3YA, UK
Danish: Northumberland NE61 3YA, Storbritannien
English: You should not take Feraccru if you are taking dimercaprol (a medicine used to remove toxic metals from the blood), chloramphenicol (used to treat bacterial infections), or methyldopa (used to treat high blood pressure).
Danish: Du må ikke få Feraccru, hvis du får dimercaprol (et lægemiddel til fjernelse af giftige metaller fra blodet), kloramfenikol (til behandling af bakterielle infektioner) eller methyldopa (til behandling af højt blodtryk).
English: Feraccru must not be administrated to children (see section 4.2).
Danish: Feraccru må ikke administreres til børn (se pkt.
English: Lactose: if you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Danish: Lactose: Hvis lægen har fortalt dig, at du ikke tåler visse sukkerarter, skal du kontakte lægen, før du tager Feraccru.
English: Early signs and symptoms include nausea, vomiting, abdominal pain and diarrhoea.
Danish: Tidlige tegn og symptomer er kvalme, opkastning, abdominalsmerter og diarré.
English: Shelf-life after first opening container: 45 days.
Danish: Holdbarhed efter anbrud af emballagen: 45 dage.
English: At doses of 500 mg/kg/day testicular degeneration and toxic signs indicative of iron chelation were recorded.
Danish: Ved doser på 500 mg/kg/dag registreredes testikulær degeneration og toksicitetstegn tydende på jernkelatering.
English: Impact of Feraccru on absorption of other medicinal products Oral iron is known to reduce the absorption of penicillamine, bisphosphonates, ciprofloxacin, entacapone, levodopa, levofloxacin, levothyroxine (thyroxine) moxifloxacin, mycophenolate, norfloxacin and ofloxacin.
Danish: Virkningen af Feraccru på absorptionen af andre lægemidler Oralt jern vides at nedsætte absorptionen af penicillamin, bisfosfonater, ciprofloxacin, entacapon, levodopa, levofloxacin, levothyroxin (thyroxin), moxifloxacin, mycophenolat, norfloxacin og ofloxacin.
English: Of the total maltol ingested, a mean of between 39.8 % and 60.0 % was excreted as maltol glucuronide.
Danish: Af den totale indtagne mængde maltol udskiltes i gennemsnit mellem 39,8 % og 60,0 % som maltolglucuronid.
English: Titanium dioxide (E171)
Danish: Titaniumdioxid (E171)
English: Poor tissue perfusion may lead to renal failure.
Danish: Dårlig vævsperfusion kan medføre nyresvigt.
English: It is not known if medical products that inhibit UGT enzymes have the potential to increase maltol concentration (see section 4.5).
Danish: Det er ukendt, om lægemidler, der hæmmer UGT-enzymer, har potentialet til at øge maltolkoncentrationen (se pkt.
English: The complex is designed to provide, in a controlled way, utilisable iron for uptake across the intestinal wall and transfer to the iron transport and storage proteins in the body (transferrin and ferritin, respectively).
Danish: Komplekset er således udformet, at det på kontrolleret måde afgiver jern, der kan udnyttes og optages gennem tarmvæggen og overføres til kroppens transport- og opbevaringsproteiner (hhv. transferrin og ferritin).
English: MARKETING AUTHORISATION NUMBER EU/1/15/1075/001
Danish: MARKEDSFØRINGSTILLADELSENS NUMMER (NUMRE) EU/1/15/1075/001
English: Uncommon side effects (may affect up to 1 in 100 people) are: thirst, stiff joints, pain in fingers/toes, headache, acne, skin redness, vomiting and increase in bacteria in the small intestine.
Danish: Ikke almindelige bivirkninger (forekommer hos indtil 1 ud af 100 personer) er: tørst, stive led, smerter i fingre/tæer, hovedpine, filipenser (akne), rødme af huden, opkastning og øget bakterieindhold i tyndtarmen.
English: Ferric maltol is not available systemically and is therefore unlikely to pass into the mother's milk.
Danish: Ferrimaltol er ikke systemisk tilgængeligt og forventes derfor ikke at gå over i modermælk.
English: All patients had discontinued from prior oral ferrous product (OFP) treatment: more than 60 % of the subjects stopped taking prior OFP due to adverse events.
Danish: Alle patienterne var ophørt med deres tidligere orale behandling med jern(II): Over 60 % af personerne ophørte med deres tidligere orale behandling med jern(II) pga. bivirkninger.
English: Ferric maltol is not systemically available.
Danish: Ferrimaltol er ikke systemisk tilgængeligt.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/15/1075/001
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/15/1075/001
English: Non-clinical studies have shown that maltol is metabolised through UGT1A6 and by sulphation.
Danish: Prækliniske studier har vist, at maltol metaboliseres via UGT1A6 og ved sulfatering.
English: Rarely, gastric scarring causing stricture or pyloric stenosis (alone or in combination) may lead to partial or complete bowel obstruction 2-5 weeks after ingestion.
Danish: I sjældne tilfælde kan der forekomme gastrisk arvævsdannelse med striktur eller pylorusstenose (alene eller i kombination), som medfører partiel eller fuldstændig tarmobstruktion 2-5 uger efter indtagelsen.
English: 69 % of the patients with UC had a SCCAI score ≤2 and 31 % a SCCAI score of 3.
Danish: 69 % af patienterne med colitis ulcerosa havde en SCCAI-score ≤2, og 31 % en SCCAI-score på 3.
English: The elderly and patients with Heaptic or renal impairment
Danish: Ældre og patienter med nedsat lever- eller nyrefunktion
English: Feraccru capsules should be taken whole on an empty stomach (with half a glass of water), as the absorption of iron is reduced when Feraccru is taken with food (see section 4.5).
Danish: Feraccru kapsler bør synkes hele på tom mave (med et halvt glas vand), da absorptionen af jern nedsættes, når Feraccru tages sammen med et måltid (se pkt.
English: These effects were not observable in a second study in dogs receiving up to 300 mg/kg/day.
Danish: Samme virkninger blev ikke iagttaget i en anden undersøgelse hos hunde, der fik op til 300 mg/kg/dag.
English: Feraccru has not been studied in patients with impaired renal and/or hepatic function.
Danish: Feraccru er ikke undersøgt hos patienter med nedsat nyre- og/eller leverfunktion.
English: Feraccru is used in adults to treat low iron stores in your body.
Danish: Feraccru anvendes hos voksne til behandling af lavt indhold af jern i kroppen.
English: • Some medicines used to treat Parkinson's disease (entacapone, levodopa) and thyroid problems
Danish: • visse lægemidler, der anvendes til behandling af Parkinsons sygdom (entacapon, levodopa), eller problemer med skjoldbruskkirtlen (levothyroxin)
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Feraccru in one or more subsets of the paediatric population in iron deficient anaemia (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har udsat forpligtelsen til at fremlægge resultaterne af studier med Feraccru i en eller flere undergrupper af den pædiatriske population ved jernmangelanæmi (se pkt.
English: • Bisphosphonates (used to treat bone diseases).
Danish: • bisfosfonater (anvendes til behandling af knoglesygdomme)
English: There are no data on the effect of ferric maltol on human fertility.
Danish: Der foreligger ingen data om virkningerne af ferrimaltol på den humane fertilitet.
English: • Titanium dioxide (E171)
Danish: • Titaniumdioxid (E171)
English: Serum iron levels measured at about 4 hours after ingestion is the best laboratory measure of severity.
Danish: Serumjern, målt omkring fire timer efter indtagelse, er den bedste laboratorieprøve til bestemmelse af sværhedsgraden.
English: Reported severe adverse reactions were abdominal pain [4%], constipation [0.9%] and diarrhoea [0.9%].
Danish: De indberettede svære bivirkninger var abdominalsmerter (4 %), konstipation (0,9 %) og diarré (0,9 %).
English: As a precautionary measure, it is preferable to avoid the use of Feraccru during pregnancy.
Danish: Som forsigtighedsforanstaltning må det foretrækkes at undgå at anvende Feraccru under graviditet.
English: Iron deficiency or iron deficiency anaemia (IDA) diagnosis should be made based on blood tests; it is important to investigate the cause of the iron deficiency and to exclude underlying causes of anaemia other than iron deficiency.
Danish: Før påbegyndelse af behandlingen bør diagnosen jernmangel eller jernmangelanæmi stilles på grundlag af blodprøver; det er vigtigt at undersøge årsagen til jernmanglen og at udelukke andre underliggende årsager til anæmien end jernmangel.
English: Maximum total iron serum concentrations were measured 1-2 hours after administration.
Danish: Det maksimale totale serumjern blev målt 1-2 timer efter administration.
English: Administration of iron preparations with such compounds should be separated by at least 2 hours.
Danish: Administration af jernpræparater og sådanne stoffer bør ske med mindst 2 timers mellemrum.
English: The pharmacokinetic properties of Feraccru were also investigated at steady state in 15 subjects who were already participating in the AEGIS1/2 study described above and who had been in the open-label treatment phase for at least 7 days (Feraccru 30 mg twice daily).
Danish: De farmakokinetiske egenskaber af Feraccru blev desuden undersøgt ved steady state hos 15 personer, der i forvejen deltog i den beskrevne AEGIS1/2-undersøgelse, og som havde været igennem den åbne behandlingsfase i mindst 7 dage (Feraccru 30 mg to gange dagligt).
English: Reporting of suspected adverse reactions:
Danish: Indberetning af formodede bivirkninger:
English: The most frequently reported adverse reactions were gastrointestinal symptoms (abdominal pain [8%], flatulence [4%], constipation [4%], abdominal discomfort [2%]/distension [2%] and diarrhoea [3%]) and these were mainly mild to moderate in severity.
Danish: De hyppigst indberettede bivirkninger var gastrointestinale symptomer: abdominalsmerter (8 %), flatulens (4 %), konstipation (4 %), abdominalt ubehag (2 %)/udspiling (2 %) og diarré (3 %); disse var hovedsagelig lette til moderate.
English: The safety and efficacy of Feraccru for the treatment of iron deficiency anaemia was studied in 128 patients (age range 18-76 years; 45 males and 83 females) with inactive to mildly active IBD (58 patients with Ulcerative Colitis [UC] and 70 patients with Crohn's disease [CD]) and baseline Hb concentrations between 9.5 g/dL and 12 / 13 g/dL for females / males.
Danish: Feraccrus sikkerhed og virkning ved behandling af jernmangelanæmi blev undersøgt hos 128 patienter (alder 18-76 år; 45 mænd og 83 kvinder) med inaktiv til let aktiv irritabel tarmsygdom (58 patienter med colitis ulcerosa og 70 patienter med Crohns sygdom) og baselinekoncentrationer af Hb på mellem 9,5 g/dL og 12 / 13 g/dL for kvinder / mænd.
English: Concomitant administration of Feraccru and intravenous iron should be avoided as the combination may induce hypotension or even collapse due to the fast release of iron resulting from saturation of transferrin caused by intravenous iron.
Danish: Sideløbende administration af Feraccru og intravenøst jern bør undgås, da denne kombination kan medføre hypotension eller endog kollaps som følge af den hurtige frigivelse af jern, da transferrin mættes af intravenøst jern.
English: Maltol was again transiently measured in plasma with a half-life of 0.7 hours, with a Cmax of 67.3 + 28.3 ng/mL.
Danish: Maltol blev igen forbigående målt i plasma og havde en halveringstid på 0,7 timer og en Cmax på 67,3 + 28,3 ng/ml.
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Danish: • Overfølsomhed for det aktive stof eller for et eller flere af hjælpestofferne anført i pkt.
English: Tabulated list of adverse reactions Table 1 presents all adverse reactions occurring during clinical studies to date with Feraccru.
Danish: Tabel over bivirkninger Tabel 1 viser alle bivirkninger, der er forekommet i kliniske studier med Feraccru til dato.
English: The maltol appeared to be rapidly metabolised to maltol glucuronide (AUC0-t between 9.83 and 30.9 h.µg/mL across all dosage regimens).
Danish: Maltol viste sig at blive metaboliseret hurtigt til maltolglucuronid ( AUC0-t mellem 9,83 og 30,9 h.µg/ml for alle dosisregimer).
English: The maltol appeared to be rapidly metabolised to maltol glucuronide (Cmax = 4677 + 1613 ng/mL).
Danish: Maltol blev hurtigt metaboliseret til maltolglucuronid (Cmax = 4 677 + 1 613 ng/ml).
English: Non-clinical studies revealed no special hazard for humans based on repeated dose toxicity and local tolerance studies conducted with ferric maltol.
Danish: De prækliniske data viste ingen speciel risiko for mennesker baseret på undersøgelser af toksicitet ved gentagen dosering og lokal tolerance af ferrimaltol.
English: Immediate packaging: bottle label
Danish: Indre emballage: Flaskeetiket
English: Subjects were randomised to receive either 30 mg Feraccru twice daily or a matched placebo control for 12 weeks.
Danish: Personerne blev randomiseret til enten 30 mg Feraccru to gange dagligt eller tilsvarende placebo i 12 uger.
English: Medicinal products that may impact absorption and distribution of iron from Feraccru Absorption of oral iron may be reduced by calcium and magnesium salts (such as magnesium trisilicate).
Danish: Lægemidler, der kan indvirke på absorptionen og fordelingen af jern fra Feraccru Calcium- og magnesiumsalte (såsom magnesiumtrisilicat) kan nedsætte absorptionen af oralt jern.