FrancophonIA/ELRC3.0 huggingface dataset:
English: Across studies, administration of Kaletra 400/100 mg twice daily yields mean steady-state lopinavir plasma concentrations 15 to 20-fold higher than those of ritonavir in HIV-infected patients.
Slovenian: Po podatkih iz več študij je bila med uporabo zdravila Kaletra 400/100 mg dvakrat na dan pri bolnikih, okuženih s HIV, povprečna plazemska koncentracija lopinavirja v stanju dinamičnega ravnovesja od 15- do 20-krat večja kot koncentracija ritonavirja.
English: Antifungals Ketoconazole and Itraconazole
Slovenian: Antimikotiki Ketokonazol in itrakonazol
English: The safety of Kaletra has been investigated in over 2600 patients in Phase II-IV clinical trials, of which over 700 have received a dose of 800/200 mg (6 capsules or 4 tablets) once daily.
Slovenian: do IV. faze, v katerih jih je preko 700 prejemalo odmerek 800/200 mg (6 kapsul ali 4 tablete) enkrat dnevno.
English: HIV RNA < 400 copies/ml* Median change from baseline in CD4+ T-cell count (cells/mm3)
Slovenian: HIV RNA < 400 kopij/ml* Mediana sprememba od izhodišča v številu T-celic CD4 (celic/mm3)
English: • In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Slovenian: Po začetku jemanja zdravil za zdravljenje vaše infekcije s HIV se lahko poleg oportunističnih infekcij pojavijo tudi avtoimunske bolezni (stanje, ki se pojavi, ko imunski sistem napade zdravo tkivo).
English: Voriconazole
Slovenian: Vorikonazol
English: Afatinib (Ritonavir 200 mg twice daily)
Slovenian: Afatinib (Ritonavir 200 mg dvakrat na dan)
English: They were randomised in a 1:1 ratio to receive either lopinavir/ritonavir 800/200 mg once daily (n = 300) or lopinavir/ritonavir 400/100 mg twice daily (n = 299).
Slovenian: V razmerju 1:1 so jih randomizirali na zdravljenje z lopinavirjem/ritonavirjem 800/200 mg enkrat na dan (n = 300) ali lopinavirjem/ritonavirjem 400/100 mg dvakrat na dan (n = 299).
English: Polyvinyl alcohol, talc, titanium dioxide, macrogols type 3350, yellow ferric oxide E172.
Slovenian: Polivinilalkohol, smukec, titanov dioksid, makrogol 3350, rumeni železov oksid E172.
English: Lopinavir/ritonavir was not found to be mutagenic or clastogenic in a battery of in vitro and in vivo assays including the Ames bacterial reverse mutation assay, the mouse lymphoma assay, the mouse micronucleus test and chromosomal aberration assays in human lymphocytes.
Slovenian: Mutagenost lopinavirja/ritonavirja so preizkusili s skupino preskusov in vitro in in vivo, med drugim z Amesovim preskusom bakterijske reverzne mutacije, mišjim limfomskim preskusom, mikronukleusnim testom pri miših in preskusi kromosomskih aberacij v človeških limfocitih; nobeden ni pokazal, da bi bila kombinacija mutagena ali klastogena.
English: The concomitant administration with fusidic acid is contraindicated in dermatological infections (see section 4.5).
Slovenian: Sočasna uporaba fusidne kisline je kontraindicirana pri dermatoloških okužbah (glejte poglavje 4.5).
English: − If you notice you miss a dose by more than 12 hours after your normal dosing time, do not take the missed dose.
Slovenian: Če opazite, da ste pozabili vzeti odmerek zdravila več kot 12 ur po predvidenem času jemanja, ne vzemite izpuščenega odmerka.
English: Co-administration of Kaletra with tadalafil is not recommended.
Slovenian: Kaletra s tadalafilom ni priporočljiva.
English: The adverse clinical signs observed in dogs included salivation, emesis and diarrhoea/abnormal stool.
Slovenian: Med neželenimi kliničnimi znaki pri psih so bili slinjenje, emeza in driska oz. nenormalno blato.
English: Ethinyl Oestradiol: ↓
Slovenian: Etinilestradiol: ↓
English: Lipid-modifying agents HMG Co-A Reductase Inhibitors
Slovenian: Zaviralci reduktaze HMG Co-A
English: Rare reports of 2nd or 3rd degree atroventricular block in patients with underlying structural heart disease and pre-existing conduction system abnormalities or in patients receiving drugs known to prolong the PR interval (such as verapamil or atazanavir) have been reported in patients receiving lopinavir/ritonavir.
Slovenian: Med zdravljenjem z lopinavirjem/ritonavirjem so redko poročali o atrioventrikularnem bloku 2. ali 3. stopnje pri bolnikih, ki so imeli osnovno organsko bolezen in že obstoječe nepravilnosti prevodnega sistema, in bolnikih, zdravljenih z zdravili, ki podaljšajo interval PR (npr. verapamil ali atazanavir).
English: Includes: alcohol, high fructose corn syrup, propylene glycol, glycerol, polyoxyl 40 hydrogenated castor oil, potassium (as acesulfame potassium).
Slovenian: Vsebuje: alkohol, visokofruktozni koruzni sirup, propilenglikol, glicerol, makrogolglicerol 40 hidrogenirano ricinusovo olje, kalij (kot kalijev acesulfamat).
English: Hypromellose, titanium dioxide, macrogols type 400 (polyethylene glycol 400), hydroxypropyl cellulose, talc, colloidal anhydrous silica, macrogols type 3350 (polyethylene glycol 3350), yellow ferric oxide E172, polysorbate 80.
Slovenian: Hipromeloza, titanov dioksid, makrogol 400 (polietilenglikol 400), hidroksipropilceluloza, smukec, brezvodni koloidni silicijev dioksid, makrogol 3350 (polietilenglikol 3350), rumeni železov oksid E172, polisorbat 80.
English: − If you notice you miss a dose by more than 6 hours after your normal dosing time, do not take the missed dose.
Slovenian: Če opazite, da ste pozabili vzeti odmerek zdravila več kot 6 ur po predvidenem času jemanja, ne vzemite izpuščenega odmerka.
English: More frequent electrocardiogram monitoring and monitoring of transaminases is recommended (see section 4.5 and refer to the bedaquiline SmPC).
Slovenian: Priporočeno je pogostejše spremljanje z elektrokardiogrami in spremljanje koncentracij transaminaz (glejte poglavje 4.5 in se obrnite na informacije v povzetku glavnih značilnosti zdravila za bedakilin).
English: Co-administration with other HIV protease inhibitors (PIs) According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended.
Slovenian: Glede na trenutne terapevtske smernice dvotirno zdravljenje z zaviralci proteaz praviloma ni priporočljivo.
English: ANNEX II A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Slovenian: B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA
English: Bedaquiline: AUC: ↑ 22%
Slovenian: Bedakilin: AUC: ↑ 22 %
English: If the benefit outweighs the risk, co-administration of bedaquiline with Kaletra must be done with caution.
Slovenian: Če je korist večja od tveganja, je pri sočasni uporabi bedakilina z zdravilom Kaletra potrebna previdnost.
English: Finger grip
Slovenian: Držalo za prste
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Slovenian: S tem, ko poročate o neželenih učinkih, lahko prispevate k zagotovitvi več informacij o varnosti tega zdravila.
English: More frequent electrocardiogram monitoring and monitoring of transaminases is recommended (see section 4.4 and refer to the bedaquiline SmPC).
Slovenian: Priporočeno je pogostejše spremljanje z elektrokardiogrami in spremljanje koncentracij transaminaz (glejte poglavje 4.4 in se obrnite na informacije v povzetku glavnih značilnosti zdravila za bedakilin).
English: The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression (reduction in the activity of the immune system), higher body mass index, among others, may be some of the many risk factors for developing this disease.
Slovenian: Nekateri od številnih dejavnikov tveganja za pojav te bolezni so lahko trajanje kombiniranega protiretrovirusnega zdravljenja, uporaba kortikosteroidov, uživanje alkohola, huda imunosupresija (zmanjšanje aktivnosti imunskega odziva) in višji indeks telesne mase.
English: Since the renal clearance of lopinavir and ritonavir is negligible, increased plasma concentrations are not expected in patients with renal impairment.
Slovenian: Ledvični očistek lopinavirja in ritonavirja je zanemarljiv, zato pri bolnikih z okvaro ledvic ni pričakovati zvišane koncentracije v plazmi.
English: Concomitant use of Kaletra and fluticasone or other glucocorticoids that are metabolised by CYP3A4, such as budesonide and triamcinolone, is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section 4.5).
Slovenian: CYP3A4, kot sta budezonid in triamcinolon, se ne priporoča, razen če možna korist zdravljenja preseže tveganje za pojav sistemskih kortikosteroidnih učinkov, vključno s Cushingovim sindromom in z zaviralnim vplivom na nadledvično žlezo (glejte poglavje 4.5).
English: No dose adjustment necessary
Slovenian: Prilagoditev odmerka ni potrebna
English: Adultc a. Kaletra oral solution 230/57.5 mg/m2 twice daily regimen without nevirapine b. Kaletra oral solution 300/75 mg/m2 twice daily regimen with nevirapine c. Kaletra film-coated tablets 400/100 mg twice daily at steady state
Slovenian: Odraslic a. Zdravilo Kaletra peroralna raztopina 230/57,5 mg/m2 shema dvakrat na dan brez nevirapina b. Zdravilo Kaletra peroralna raztopina 300/75 mg/m2 shema dvakrat na dan z nevirapinom c. Zdravilo Kaletra filmsko obložene tablete 400/100 mg dvakrat na dan v stanju dinamičnega ravnovesja
English: • allergic reactions including hives and inflammation in the mouth;
Slovenian: - vnetje jeter vključno s povišanimi jetrnimi encimi; - alergijske reakcije vključno s koprivnico in vnetjem v ustih;
English: How much Kaletra should be taken and when?
Slovenian: Koliko zdravila Kaletra naj uporabim in kdaj Uporaba pri odraslih
English: Talk to your doctor or pharmacist before taking Kaletra.
Slovenian: Pred začetkom jemanja zdravila Kaletra se posvetujte z zdravnikom ali farmacevtom.
English: Kaletra is contraindicated in patients with severe liver impairment (see section 4.3).
Slovenian: Zdravilo Kaletra je kontraindicirano pri bolnikih s hudo okvaro jeter (glejte poglavje 4.3).
English: After each dose of Kaletra separate the plunger and the syringe.
Slovenian: Po vsakem odmerjanju zdravila Kaletra potegnite bat iz brizge.
English: M98-957 is a randomised, open-label study evaluating Kaletra treatment at two dose levels (400/100 mg and 533/133 mg, both twice daily) plus efavirenz (600 mg once daily) and nucleoside reverse transcriptase inhibitors in 57 multiple protease inhibitor experienced, non-nucleoside reverse transcriptase inhibitor naïve patients.
Slovenian: M98-957 je randomizirana, odprta študija za oceno zdravljenja z zdravilom Kaletra v dveh različnih odmerkih (400/100 mg in 533/133 mg, oboje dvakrat na dan) hkrati z efavirenzem (600 mg enkrat na dan) ter nukleozidnimi zaviralci reverzne transkriptaze pri 57 bolnikih, izkušenih z več zaviralci proteaz in naivnih za nenukleozidne zaviralce reverznih transkriptaz.
English: Concomitant administration of Kaletra with fusidic acid is contraindicated in dermatological indications due to the increased risk of adverse events related to fusidic acid, notably rhabdomyolysis (see section 4.3).
Slovenian: Sočasna uporaba zdravila Kaletra s fusidno kislino je kontraindicirana pri dermatoloških indikacijah, ker obstaja večje tveganje za neželene učinke, povezane s fusidno kislino, zlasti za rabdomiolizo (glejte poglavje 4.3).
English: ≥ 0.9 to < 1.4
Slovenian: ≥ 0,9 do < 1,4
English: Kaletra 100 mg/25 mg film-coated tablets are supplied in plastic bottles containing 60 tablets.
Slovenian: Filmsko obložene tablete zdravila Kaletra z jakostjo 100mg/20mg so na voljo v plastenkah, ki vsebujejo 60 tablet.
English: PARTICULARS TO APPEAR ON THE INTERMEDIATE CARTON Inner carton of multipack of 120 (3 packs of 40) 200 mg/50 mg film-coated tablets) - without blue box
Slovenian: Vmesna škatla v multipakiranju s 120 (3 pakiranja s 40) 200mg/50mg filmsko obloženimi tabletami - brez modrega okenca
English: • You must not take Kaletra with sildenafil used to treat pulmonary arterial hypertension (high blood pressure in the pulmonary artery) (see also Do not take Kaletra section above).
Slovenian: - Zdravila Kaletra ne smete jemati s sildenafilom, ki se uporablja za zdravljenje pljučne arterijske hipertenzije (visok krvni tlak v pljučni arteriji) (glejte poglavje zgoraj Ne jemljite zdravila
English: Lopinavir/ritonavir was administered twice daily at 16/4 mg/kg for subjects 2 months to < 6 months, 12/3 mg/kg for subjects ≥ 6 months and < 15 kg, 10/2.5 mg/kg for subjects ≥ 6 months and ≥ 15 kg to < 40 kg, or 400/100 mg for subjects ≥ 40 kg.
Slovenian: Preiskovanci so prejemali kombinacijo lopinavir/ritonavir dvakrat na dan v odmerkih 16/4 mg/kg pri starosti od 2 mesecev do < 6 mesecev, 12/3 mg/kg pri starosti ≥ 6 mesecev in < 15 kg, 10/2,5 mg/kg pri starosti ≥ 6 mesecev in ≥ 15 kg do < 40 kg ali 400/100 mg pri preiskovancih ≥ 40 kg. Shema z nevirapinom je vključevala 160-200 mg/m2 enkrat na dan 14 dni, nato 160-200 mg/m2 vsakih 12 ur.
English: Lipid lowering agents Lovastatin and Simvastatin
Slovenian: Zdravila za zniževanje lipidov Lovastatin in simvastatin
English: Co-administration of ibrutinib and Kaletra should be avoided.
Slovenian: Sočasni uporabi ibrutiniba in zdravila Kaletra se je treba izogniti.
English: In an open-label pharmacokinetic study, 12 HIV-infected pregnant women who were less than 20 weeks of gestation and on combination antiretroviral therapy initially received lopinavir/ritonavir 400 mg/100 mg (two 200/50 mg tablets) twice daily up to a gestational age of 30 weeks.
Slovenian: V odprti farmakokinetični študiji je 12 nosečnic, okuženih s HIV, z gestacijsko dobo manj kot 20 tednov in na kombinirani protivirusni terapiji, na začetku dobivalo lopinavir/ritonavir 400 mg/100 mg
English: Severe hepatic insufficiency.
Slovenian: Huda insuficienca jeter.
English: M97-765 is a randomised, double-blind trial evaluating Kaletra at two dose levels (400/100 mg and 400/200 mg, both twice daily) plus nevirapine (200 mg twice daily) and two nucleoside reverse transcriptase inhibitors in 70 single protease inhibitor experienced, non-nucleoside reverse transcriptase inhibitor naïve patients.
Slovenian: Študija M97-765 je randomizirano, dvojno slepo preskušanje za oceno zdravila Kaletra v dveh različnih odmerkih (400/100 mg in 400/200 mg, oboje dvakrat na dan) hkrati z nevirapinom (200 mg dvakrat na dan) ter dvema nukleozidnima zaviralcema reverzne transkriptaze pri 70 bolnikih, izkušenih z enim zaviralcem proteaz in naivnih za nenukleozidne zaviralce reverznih transkriptaz.
English: Cmax: ↑ 6-fold
Slovenian: Cmax: ↑ 6-krat
English: Buprenorphine, 16 mg QD
Slovenian: Buprenorfin, 16 mg enkrat na dan
English: AUC: ↑ 11.86-fold Cmax: ↑ 6.31-fold
Slovenian: AUC: ↑ 11,86-krat Cmax: ↑ 6,31-krat
English: If this co-administration is judged unavoidable, refer to the abemaciclib SmPC for dosage adjustment recommendations.
Slovenian: Če se sočasni uporabi ni možno izogniti, za priporočila glede prilagoditve odmerka glejte povzetek glavnih značilnosti zdravila za abemaciklib.
English: Increased plasma concentrations of lomitapide (see section 4.5).
Slovenian: Povečane koncentracije lomitapida v plazmi (glejte poglavje 4.5).
English: (Ritonavir 200 mg twice daily)
Slovenian: (Ritonavir 200 mg dvakrat na dan)
English: Increased plasma concentrations of pimozide.
Slovenian: Večja koncentracija pimozida v plazmi.
English: Dosage recommendation for paediatric patients older than 6 months to less than 18 years Without Concomitant Efavirenz or Nevirapine
Slovenian: Priporočila za odmerjanje pri pediatričnih bolnikih, starejših od 6 mesecev in mlajših od 18 let
English: Uncommon Visual impairment
Slovenian: Očesne bolezni občasni motnje vida
English: Monitor for ADRs related to ceritinib.
Slovenian: Spremljajte neželene učinke, ki so povezani s ceritinibom.
English: AUC: ↑ 2.71-fold Cmax: ↑ 1.87-fold C24: ↑ 3.58-fold
Slovenian: AUC: ↑ 2,71-krat Cmax: ↑ 1,87-krat C24: ↑ 3,58-krat
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING 200 mg/50 mg Tablets - Carton of multipack containing 360 (3 bottles of 120) film-coated tablets - including blue box
Slovenian: 200 mg/50 mg tablete - škatla multipakiranja, ki vsebuje 360 ( 3 plastenke po 120) filmsko obloženih tablet - vključno z modrim okencem
English: Open the child-proof cap by pushing down on it with your palm and twisting it counter clockwise, or in the direction of the arrow on the top of the cap. Talk to your pharmacist if you have difficulty opening the bottle.
Slovenian: Odprite za otroke varno zaporko tako, da jo z dlanjo pritisnete navzdol in zavrtite v smeri, nasprotni urinemu kazalcu oz. v smeri puščice, ki je na vrhu zaporke.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with Kaletra is required.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic ali jeter, ki potrebujejo zdravljenje z zdravilom Kaletra, je priporočljivo zmanjšati odmerek kolhicina ali prekiniti zdravljenje s kolhicinom.
English: (relative to indinavir 800 mg TID alone)
Slovenian: (v primerjavi z 800 mg samega indinavirja trikrat na dan)
English: AUC: ↑ 6.10-fold Cmax: ↑ 4.76-fold Ctrough: ↑ 12.33-fold
Slovenian: AUC: ↑ 6,10-krat Cmax: ↑ 4,76-krat Ctrough: ↑ 12,33-krat
English: Tipranavir/ritonavir (500/100 mg BID)
Slovenian: Tipranavir/ritonavir (500/100 mg dvakrat na dan)
English: Alpha1 adrenoreceptor antagonist Alfuzosin
Slovenian: Zaviralec adrenergičnih receptorjev alfa1
English: Immune Reconstitution Inflammatory Syndrome
Slovenian: Vnetni sindrom imunske rekonstitucije
English: Includes: alcohol (42 % v/v see leaflet), high fructose corn syrup, propylene glycol, glycerol, polyoxyl 40 hydrogenated castor oil, potassium (as acesulfame potassium).
Slovenian: Vsebuje: alkohol (42 % v/v, glejte navodilo za uporabo), visokofruktozni koruzni sirup, propilenglikol, glicerol, makrogolglicerol 40 hidrogenirano ricinusovo olje , kalij (kot kalijev acesulfamat).
English: • inflammation of blood vessels and capillaries;
Slovenian: - vnetje krvnih žil in kapilar;
English: Lomitapide
Slovenian: Lomitapid
English: Abacavir, Zidovudine Abacavir, Zidovudine: Concentrations may be reduced due to increased glucuronidation by lopinavir/ritonavir.
Slovenian: Abakavir, zidovudin Abakavir, zidovudin: zaradi povečane glukuronidacije zaradi lopinavirja/ritonavirja se koncentracija lahko zniža.
English: Increased plasma concentrations of amiodarone and dronedarone.
Slovenian: Večja koncentracija amiodarona in dronedarona v plazmi.
English: Vasodilating agents Bosentan
Slovenian: Vazodilatacijska zdravila Bosentan
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS 200 mg/50 mg tablets - Blister of 8 film-coated tablets or Blister of 12 film-coated tablets
Slovenian: 200 mg/50 mg tablete - pretisni omot z 8 filmsko obloženimi tabletami ali pretisni omot z 12 filmsko obloženimi tabletami
English: AUC: ↑ 2-fold Cmax: ↑ 5-fold
Slovenian: AUC: ↑ 2-krat Cmax: ↑ 5-krat
English: Ritonavir inhibits the metabolism of lopinavir, thereby increasing the plasma levels of lopinavir.
Slovenian: Ritonavir zavira presnovo lopinavirja in tako zvečuje koncentracijo lopinavirja v plazmi.
English: Rilpivirine (Lopinavir/ritonavir capsule 400/100 mg BID)
Slovenian: Rilpivirin (Lopinavir/ritonavir kapsula 400/100 mg dvakrat na dan)
English: Kaletra pharmacokinetics have not been studied in patients with renal insufficiency; however, since the renal clearance of lopinavir is negligible, a decrease in total body clearance is not expected in patients with renal insufficiency.
Slovenian: A ker je ledvični očistek lopinavirja zanemarljiv, pri bolnikih z ledvično insuficienco ni pričakovati zmanjšanja celotnega telesnega očistka.
English: Kaletra (80 mg + 20 mg) / ml oral solution (lopinavir + ritonavir)
Slovenian: Kaletra (80 mg + 20 mg) / ml peroralna raztopina (lopinavir + ritonavir)
English: Concomitant use of neratinib with Kaletra is contraindicated due to serious and/or life-threatening potential reactions including hepatotoxicity (see section 4.3).
Slovenian: Sočasna uporaba neratiniba in zdravila Kaletra je kontraindicirana zaradi možnih resnih in/ali življenje ogrožajočih reakcij, vključno s hepatotoksičnostjo (glejte poglavje 4.3).
English: AUC: ↑ 13-fold
Slovenian: AUC: ↑ 13-krat
English: Virologic Response of Study Subjects at Week 48 Study 802 QD BID Difference [95% CI]
Slovenian: Virološki odziv preiskovancev v študiji 48. teden študije 802 Enkrat na dan
English: Increased plasma concentrations of vardenafil (see sections 4.4 and 4.5)
Slovenian: Večja koncentracija vardenafila v plazmi (glejte poglavji 4.4 in 4.5)
English: The pharmacokinetics of Kaletra oral solution 300/75 mg/m2 twice daily and 230/57.5 mg/m2 twice daily have been studied in a total of 53 paediatric patients, ranging in age from 6 months to 12 years.
Slovenian: Farmakokinetiko peroralne raztopine zdravila Kaletra 300/75 mg/m2 dvakrat na dan in 230/57,5 mg/m2 dvakrat na dan so raziskali pri skupaj 53 pediatričnih bolnikih, starih od 6 mesecev do 12 let.
English: b. Tabulated list of adverse reactions
Slovenian: b. Seznam neželenih učinkov v preglednici
English: Concomitant administration of Kaletra and astemizole and terfenadine is contraindicated as it may increase the risk of serious arrhythmias from these agents (see section 4.3).
Slovenian: Sočasna uporaba zdravila Kaletra z astemizolom in terfenadinom je kontraindicirana, ker lahko poveča tveganje resnih aritmij zaradi teh zdravil (glejte poglavje
English: • If you are pregnant or breastfeeding, talk to your doctor or pharmacist before taking this medicine because it contains propylene glycol and alcohol.
Slovenian: - Če ste noseči ali dojite, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo,
English: Glecaprevir/pibrentasvir Serum concentrations may be increased due to P-glycoprotein, BCRP and OATP1B inhibition by lopinavir/ritonavir.
Slovenian: Glekaprevir/pibrentasvir Serumske koncentracije se lahko zvišajo zaradi zavrtja Pglikoproteina, BCRP in OATP1B z lopinavirjem/ritonavirjem.
English: • Your doctor will decide the right dose based on the child's height and weight.
Slovenian: - Pravi odmerek za otroka bo zdravnik določil na osnovi otrokove višine in telesne mase.
English: Events noted as having frequency “Not known” were identified via post-marketing surveillance.
Slovenian: Dogodki z neznano pogostnostjo so bili opaženi v obdobju spremljanja zdravila po prihodu na trg.
English: During in vitro studies, cloned human cardiac potassium channels (HERG) were inhibited by 30% at the highest concentrations of lopinavir/ritonavir tested, corresponding to a lopinavir exposure 7-fold total and 15-fold free peak plasma levels achieved in humans at the maximum recommended therapeutic dose.
Slovenian: Med študijami in vitro so največje preizkušene koncentracije lopinavirja/ritonavirja zavrle klonirane človeške srčne kanale za kalij (HERG) za 30 %; izpostavljenost ustreza izpostavljenosti lopinavirju ob
English: • ranolazine (used to treat chronic chest pain [angina]);
Slovenian: - ranolazin (uporablja se za zdravljenje kronične bolečine v prsnem košu [angina pektoris]); - cisaprid (uporablja se za lajšanje določenih težav z želodcem);
English: BSA (m2) = √ (Height (cm) X Weight (kg) / 3600)
Slovenian: *Telesno površino lahko izračunamo po enačbi telesna površina (m2) = √ (višina (cm) X telesna masa (kg) / 3600)