FrancophonIA/ELRC3.0 huggingface dataset:
English: 14 tablets in 1 PVC/aluminium foil blister in wallet card with 7 × 30 mg and 7 × 90 mg tablets 28 tablets in 2 PVC/aluminium foil blisters in wallet card with 7 × 30 mg and 7 × 90 mg tablets 56 tablets in 4 PVC/aluminium foil blisters in wallet card with 7 × 30 mg and 7 × 90 mg tablets
Slovenian: 14 tablet v 1 pretisnem omotu PVC/aluminijasta folija v zgibanki s 7 × 30 mg in 7 × 90 mg tabletami 28 tablet v 2 pretisnih omotih PVC/aluminijasta folija v zgibanki s 7 × 30 mg in 7 × 90 mg tabletami 56 tablet v 4 pretisnih omotih PVC/aluminijasta folija v zgibanki s 7 × 30 mg in 7 × 90 mg tabletami
English: België/Belgique/Belgien Otsuka Pharmaceutical Netherlands B.V. Tél/Tel: +31 (0) 20 85 46 555
Slovenian: België/Belgique/Belgien Otsuka Pharmaceutical Netherlands B.V.
English: Jinarc 30 mg tablets + Jinarc 90 mg tablets 14 tablets in 1 PVC/aluminium foil blister with 7 × 30 mg and 7 × 90 mg tablets 28 tablets in 2 PVC/aluminium foil blisters with 7 × 30 mg and 7 × 90 mg tablets 56 tablets in 4 PVC/aluminium foil blisters with 7 × 30 mg and 7 × 90 mg tablets
Slovenian: 14 tablet v 1 pretisnem omotu PVC/aluminijasta folija s 7 × 30 mg in 7 × 90 mg tabletami 28 tablet v 2 pretisnih omotih PVC/aluminijasta folija s 7 × 30 mg in 7 × 90 mg tabletami 56 tablet v 4 pretisnih omotih PVC/aluminijasta folija s 7 × 30 mg in 7 × 90 mg tabletami
English: • find it difficult to urinate.
Slovenian: • težko odvajate vodo
English: • shortness of breath
Slovenian: • razbijanje srca
English: Aspartate aminotransferase increased,
Slovenian: Preiskave zvišana raven alanin aminotransferaz, zvišana raven aspartat aminotransferaz, zmanjšana telesna masa zvišana raven bilirubina
English: The treatment difference in eGFR change observed in this trial is 1.27 mL/min/1.73 m 2, representing a
Slovenian: Zmanjšanje eGFRCKD-EPI od 72,2 do 9,79 (ml/min/1,73 m2) je bilo povezano z
English: Otsuka Pharmaceutical Netherlands B.V. Thλ: +31 (0) 20 85 46 555
Slovenian: Thλ: +31 (0) 20 85 46 555
English: • muscle spasms
Slovenian: • suha usta
English: Strength Pharmaceutical Form Route of Administration Packaging
Slovenian: ime jakost farmacevtska oblika pot uporabe ovojnina velikost pakiranja
English: EMEA Number
Slovenian: številka EU
English: This summary was last updated in 07-2017.
Slovenian: Povzetek je bil nazadnje posodobljen 07-2017.
English: clopidogrel
Slovenian: klopidogrel
English: The full EPAR for Clopidogrel TAD can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Klopidogrel TAD je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Clopidogrel TAD on 23 September 2009.
Slovenian: Evropska komisija je dovoljenje za promet z zdravilom Klopidogrel TAD, veljavno po vsej Evropski uniji, izdala 23. septembra 2009.
English: The standard dose is one 75-mg tablet once a day.
Slovenian: Običajni odmerek zdravila je ena 75-miligramska tableta enkrat na dan.
English: • recently had a myocardial infarction (heart attack).
Slovenian: • so nedavno doživeli miokardni infarkt (srčni napad).
English: Clopidogrel TAD
Slovenian: Klopidogrel TAD
English: What measures are being taken to ensure the safe and effective use of Clopidogrel TAD?
Slovenian: Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Klopidogrel TAD?
English: This is a summary of the European public assessment report (EPAR) for Clopidogrel TAD.
Slovenian: To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Klopidogrel TAD.
English: • peripheral arterial disease (problems with blood flow in the arteries);
Slovenian: • imajo periferno arterijsko bolezen (težave s pretokom krvi v arterijah);
English: This means that Clopidogrel TAD is similar to a ‘reference medicine' already authorised in the European Union (EU) called Plavix.
Slovenian: To pomeni, da je podobno „referenčnemu zdravilu“, ki je že odobreno v Evropski uniji (EU), in sicer zdravilu Plavix.
English: What are the benefits and risks of Clopidogrel TAD?
Slovenian: Kakšne so koristi in tveganja, povezani z zdravilom Klopidogrel TAD?
English: This stops the platelets becoming ‘sticky', reducing the risk of a blood clot forming and helping to prevent another heart attack or stroke.
Slovenian: To preprečuje, da bi trombociti postali „lepljivi“, ter tako zmanjšuje tveganje za nastanek krvnih strdkov in prispeva k preprečitvi novega srčnega napada ali kapi.
English: In acute coronary syndrome and atrial fibrillation, Clopidogrel TAD is used together with aspirin, the dose of which should not be higher than 100 mg.
Slovenian: Pri akutnem koronarnem sindromu in atrijski fibrilaciji se zdravilo Klopidogrel TAD uporablja skupaj z aspirinom, katerega odmerek ne sme biti višji od 100 mg.
English: Acute coronary syndrome is a group of heart problems that include heart attacks and unstable angina (a severe type of chest pain).
Slovenian: Akutni koronarni sindrom je skupina obolenj srca, ki zajema tudi srčni napad in nestabilno angino pektoris (hudo obliko bolečine v prsih).
English: What is Clopidogrel TAD and what is it used for?
Slovenian: Kaj je zdravilo Klopidogrel TAD in za kaj se uporablja?
English: This is then followed by the standard 75-mg dose once a day for at least four weeks (in ‘ST segment elevation' myocardial infarction) or for up to 12 months (in unstable angina or ‘non-Q-wave' myocardial infarction).
Slovenian: Temu sledi običajni 75-miligramski odmerek enkrat na dan v trajanju najmanj štirih tednov (pri miokardnem infarktu z dvigom spojnice ST) ali največ 12 mesecev (pri nestabilni angini pektoris ali pri miokardnem infarktu brez zobca Q).
English: It is used in those patients who have at least one risk factor for vascular events such as a heart attack or stroke, cannot take vitamin K antagonists (other medicines that prevent blood clots) and are at low risk of bleeding.
Slovenian: Uporablja se pri tistih bolnikih, ki imajo vsaj en dejavnik tveganja za vaskularne dogodke, kot so srčni napad ali možganska kap, ter tistih, ki ne smejo jemati antagonistov vitamina K (drugega zdravila, ki preprečuje krvne strdke) in pri katerih je tveganje za krvavitve majhno.
English: For more information about treatment with Clopidogrel TAD, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Klopidogrel TAD preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Clopidogrel TAD have been included in the summary of product characteristics and the package leaflet.
Slovenian: Priporočila in varnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Klopidogrel TAD upoštevati zdravstveni delavci in bolniki, so vključeni v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo.
English: In acute coronary syndrome, treatment generally starts with a loading dose of four tablets.
Slovenian: Pri akutnem koronarnem sindromu se zdravljenje načeloma uvede z začetnim odmerkom štirih tablet.
English: Clopidogrel TAD can be started between a few days and 35 days after the attack;
Slovenian: Zdravilo Klopidogrel TAD se lahko začne jemati od nekaj dni po napadu do 35 dni po njem;
English: Because Clopidogrel TAD is a generic medicine and is bioequivalent to the reference medicine, its benefits and risks are taken as being the same as the reference medicine's.
Slovenian: Ker je zdravilo Klopidogrel TAD generično zdravilo in je biološko enakovredno referenčnemu zdravilu, so njegove koristi in tveganja enaki kot pri referenčnem zdravilu.
English: Clopidogrel TAD is a medicine used to prevent problems caused by blood clots in adults who have:
Slovenian: Zdravilo Klopidogrel TAD se uporablja za preprečevanje težav, ki jih povzročajo krvni strdki pri odraslih, ki:
English: Clopidogrel stops the platelets aggregating by blocking a substance called ADP from attaching to a special receptor on their surface.
Slovenian: Klopidogrel njihovo agregacijo zavira tako, da snovi, imenovani ADP, prepreči, da bi se vezala na posebne receptorje na njihovi površini.
English: The European Medicines Agency concluded that, in accordance with EU requirements, Clopidogrel TAD has been shown to have comparable quality and to be bioequivalent to Plavix.
Slovenian: Evropska agencija za zdravila je zaključila, da je bilo v skladu z zahtevami EU dokazano, da ima to zdravilo primerljivo raven kakovosti kot referenčno zdravilo Plavix ter da mu je biološko enakovredno.
English: It is not intended to provide practical advice on how to use Clopidogrel TAD.
Slovenian: Povzetek ni namenjen zagotavljanju praktičnih nasvetov o njegovi uporabi.
English: Clopidogrel TAD is available as tablets containing 75 mg clopidogrel.
Slovenian: Zdravilo Klopidogrel TAD je na voljo v obliki tablet, ki vsebujejo 75 mg klopidogrela.
English: For practical information about using Clopidogrel TAD, patients should read the package leaflet or contact their doctor or pharmacist.
Slovenian: Za praktične informacije o uporabi zdravila Klopidogrel TAD naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
English: The Agency recommended that Clopidogrel TAD be approved for use in the EU.
Slovenian: Priporočila je, da se zdravilo odobri za uporabo v EU.
English: Why is Clopidogrel TAD approved?
Slovenian: Zakaj je bilo zdravilo Klopidogrel TAD odobreno?
English: • recently had an ischaemic stroke (stroke caused by failure of the blood supply to part of the brain).
Slovenian: • so nedavno utrpeli ishemično kap (kap zaradi neoskrbe določenega dela možganov s krvjo).
English: Because Clopidogrel TAD is a generic medicine, studies in people have been limited to tests to determine that it is bioequivalent to the reference medicine, Plavix.
Slovenian: Ker je zdravilo Klopidogrel TAD generično zdravilo, so bile študije pri ljudeh omejene na preskuse za ugotavljanje, ali je biološko enakovredno referenčnemu zdravilu Plavix.
English: Clopidogrel TAD is a ‘generic medicine'.
Slovenian: Klopidogrel TAD je „generično zdravilo“.
English: • atrial fibrillation (irregular rapid contractions of the upper chambers of the heart), when it should be given with aspirin.
Slovenian: • trpijo za atrijsko fibrilacijo (nerednim hitrim krčenjem zgornjih srčnih preddvorov), pri katerih se mora zdravilo dajati skupaj z aspirinom.
English: Clopidogrel TAD can be started between seven days and six months after the stroke;
Slovenian: Zdravilo Klopidogrel TAD se lahko začne jemati od sedem dni po napadu do šest mesecev po njem;
English: Therefore, the Agency's view was that, as for Plavix, the benefit outweighs the identified risk.
Slovenian: Zato je menila, da njegove koristi enako kot pri zdravilu Plavix odtehtajo znana tveganja.
English: Other information about Clopidogrel TAD
Slovenian: Druge informacije o zdravilu Klopidogrel TAD
English: When the blood clots, this is due to special cells in the blood called platelets aggregating (sticking together).
Slovenian: Strjevanje krvi je posledica agregacije (zlepljanja) posebnih celic v krvi, imenovanih trombociti.
English: • a condition known as ‘acute coronary syndrome', when it should be given with aspirin (another medicine that prevents blood clots).
Slovenian: • imajo akutni koronarni sindrom, pri katerem se mora zdravilo dajati skupaj z aspirinom (drugim zdravilom za preprečevanje krvnih strdkov).
English: Some of these patients may have had a stent (a short tube) placed in an artery to prevent it from closing up;
Slovenian: Nekaterim bolnikom je bil morda v arterijo vstavljen stent (kratka cevka), da prepreči njeno zamašitev;
English: The active substance in Clopidogrel TAD, clopidogrel, is an inhibitor of platelet aggregation.
Slovenian: Zdravilna učinkovina zdravila Klopidogrel TAD, klopidogrel, je zaviralec agregacije trombocitov.
English: How has Clopidogrel TAD been studied?
Slovenian: Kako je bilo zdravilo Klopidogrel TAD raziskano?
English: How is Clopidogrel TAD used?
Slovenian: Kako se zdravilo Klopidogrel TAD uporablja?
English: Clopidogrel TAD contains the active substance clopidogrel.
Slovenian: Zdravilo Klopidogrel TAD vsebuje zdravilno učinkovino klopidogrel.
English: How does Clopidogrel TAD work?
Slovenian: Kako zdravilo Klopidogrel TAD deluje?
English: Clopidogrel TAD can only be obtained with a prescription.
Slovenian: Predpisovanje in izdaja zdravila Klopidogrel TAD je le na recept.
English: This summary was last updated in 11-2017.
Slovenian: Povzetek je bil nazadnje posodobljen 11-2017.
English: The first dose should be followed by 3 more doses after 2, 4, and 9 weeks and then one dose every 4 months thereafter.
Slovenian: Prvemu odmerku morajo slediti še trije odmerki po 2, 4 in 9 tednih, nato pa en odmerek na vsake štiri mesece.
English: This replaces the missing protein, thereby relieving the symptoms of the disease.
Slovenian: S tem nadomesti manjkajočo beljakovino in olajša simptome bolezni.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Spinraza on 30 May 2017.
Slovenian: Evropska komisija je dovoljenje za promet z zdravilom Spinraza, veljavno po vsej Evropski uniji, izdala 30. maja 2017.
English: In babies some side effects could not be assessed, as they could not communicate them.
Slovenian: Pri dojenčkih določenih neželenih učinkov ni bilo mogoče oceniti zaradi njihove nezmožnosti sporočanja.
English: In its assessment, the European Medicines Agency recognised the serious nature of the disease and the urgent need for effective treatments.
Slovenian: Evropska agencija za zdravila je v svoji oceni prepoznala resnost bolezni in nujno potrebo po učinkovitem zdravljenju.
English: What measures are being taken to ensure the safe and effective use of Spinraza?
Slovenian: Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Spinraza?
English: Although the medicine was not tested in patients with the most severe and the mildest forms of SMA, it is expected to provide similar benefits to these patients.
Slovenian: Čeprav zdravilo pri bolnikih z najhujšo in najbolj blago obliko SMA ni bilo preskušeno, se pričakujejo podobne koristi zdravljenja tudi pri teh bolnikih.
English: The disease is linked to a defect on chromosome 5q and symptoms usually start shortly after birth.
Slovenian: Bolezen je povezana z okvaro na kromosomu 5q, simptomi pa se običajno pojavijo kmalu po rojstvu.
English: This is a summary of the European public assessment report (EPAR) for Spinraza.
Slovenian: To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Spinraza.
English: The most common side effects with Spinraza (which may affect more than 1 in 10 people) are headache, back pain and vomiting.
Slovenian: Najpogostejši neželeni učinki zdravila Spinraza (ki lahko prizadenejo več kot 1 osebo od 10) so glavobol, bolečine v hrbtu in bruhanje.
English: The recommended dose is 12 mg (one vial), given as soon as possible after the patient has been diagnosed with SMA.
Slovenian: Priporočeni odmerek je 12 mg (ena viala), ki ga je treba dati čim prej po postavitvi diagnoze SMA.
English: It is given by intrathecal injection (into the lower back, directly into the spine) by a doctor or nurse experienced in carrying out this procedure.
Slovenian: Z intratekalno injekcijo (v spodnji del hrbta, neposredno v hrbtenico) ga daje zdravnik ali medicinska sestra, ki ima izkušnje z izvajanjem tega posega.
English: The company that markets Spinraza will complete ongoing studies of the long-term safety and effectiveness of the medicine in patients who are showing symptoms of SMA and patients not yet showing symptoms.
Slovenian: Družba, ki trži zdravilo Spinraza, bo dokončala potekajoče študije dolgoročne varnosti in učinkovitosti zdravila pri bolnikih, ki kažejo simptome SMA, in bolnikih, ki simptomov še ne kažejo.
English: In addition, most babies treated with Spinraza survived for longer and needed breathing support later than those given placebo.
Slovenian: Poleg tega so dojenčki, ki so bili zdravljeni z zdravilom Spinraza, večinoma preživeli dlje kot tisti, ki so prejemali placebo, in so podporo dihanju potrebovali pozneje.
English: The summary of the opinion of the Committee for Orphan Medicinal Products for Spinraza can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/Rare disease designation.
Slovenian: Povzetek mnenja Odbora za zdravila sirote o zdravilu Spinraza je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/Rare disease designation.
English: After one year of treatment, 51% of babies receiving Spinraza (37 out of 73) showed progress in developing head control, rolling, sitting, crawling, standing and walking, whereas no similar progress was seen in any of the babies who received placebo.
Slovenian: Po enem letu zdravljenja, se je pri 51 % (37 od 73) dojenčkov, ki so prejemali zdravilo Spinraza pokazalo napredovanje pri razvoju obvladovanja glave, kotaljenja, sedenja, plazenja, stoječega položaja in hoje, pri dojenčkih, ki so prejemali placebo, pa podobno napredovanje ni bilo ugotovljeno v nobenem primeru.
English: The SMN protein is made from two genes, SMN1 and SMN2.
Slovenian: Beljakovino SMN sestavljata dva gena, SMN1 in SMN2.
English: The Agency therefore decided that Spinraza's benefits are greater than its risks and recommended that it be approved for use in the EU.
Slovenian: Agencija je zato zaključila, da so koristi zdravila Spinraza večje od z njim povezanih tveganj, in priporočila, da se odobri za uporabo v EU.
English: What is Spinraza and what is it used for?
Slovenian: Kaj je zdravilo Spinraza in za kaj se uporablja?
English: Because the number of patients with SMA is low, the disease is considered ‘rare', and Spinraza was designated an ‘orphan medicine' (a medicine used in rare diseases) on 2 April 2012.
Slovenian: Ker je bolnikov s SMA malo, velja ta bolezen za redko, zato je bilo zdravilo Spinraza 2. aprila 2012 določeno kot „zdravilo sirota“ (zdravilo za zdravljenje redkih bolezni).
English: Other information about Spinraza
Slovenian: Druge informacije o zdravilu Spinraza
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Spinraza have also been included in the summary of product characteristics and the package leaflet.
Slovenian: Priporočila in varnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Spinraza upoštevati zdravstveni delavci in bolniki, so vključeni tudi v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo.
English: What are the risks associated with Spinraza?
Slovenian: Kakšna tveganja so povezana z zdravilom Spinraza?
English: Another study assessed Spinraza's effectiveness in children whose SMA was less severe and diagnosed at a later stage (average age of 3 years).
Slovenian: V drugi študiji so ocenili učinkovitost zdravila Spinraza pri otrocih, pri katerih je SMA manj huda in je bila diagnoza postavljena pozneje (pri povprečni starosti treh let).
English: What benefits of Spinraza have been shown in studies?
Slovenian: Kakšne koristi je zdravilo Spinraza izkazalo v študijah?
English: One main study, involving 121 babies (of an average age of 7 months) with SMA, showed that Spinraza is effective in improving movement when compared with placebo (sham injection).
Slovenian: Ena glavna študija, v katero je bilo vključenih 121 dojenčkov (povprečne starosti 7 mesecev) s SMA, je pokazala, da zdravilo Spinraza v primerjavi s placebom (injekcijo brez zdravilne učinkovine) učinkovito izboljša gibanje.
English: For more information about treatment with Spinraza, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Spinraza preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: Side effects were considered manageable, with most side effects related to the way the medicine is given.
Slovenian: Neželeni učinki veljajo za obvladljive in so večinoma povezani z načinom dajanja zdravila.
English: The medicine is available as a solution for injection in 12 mg vials.
Slovenian: Na voljo je v obliki raztopine za injiciranje v vialah z 12 mg učinkovine.
English: It is not intended to provide practical advice on how to use Spinraza.
Slovenian: Povzetek ni namenjen zagotavljanju praktičnih nasvetov o njegovi uporabi.
English: After 15 months of treatment, 57% of children receiving Spinraza showed improvement in movement compared with 26% of children on placebo.
Slovenian: Po 15 mesecih zdravljenja, je bilo pri 57 % otrok, ki so prejemali zdravilo Spinraza, ugotovljeno izboljšanje gibanja, medtem ko je bilo med otroci, ki so prejemali placebo, takšnih otrok 26 %.
English: The full EPAR for Spinraza can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Spinraza je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: For the full list of all side effects and restrictions with Spinraza, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov in omejitev pri uporabi zdravila Spinraza glejte navodilo za uporabo.
English: Spinraza is a medicine used to treat 5q spinal muscular atrophy (SMA), a genetic disease that causes weakness and wasting of the muscles including the lung muscles.
Slovenian: Spinraza je zdravilo, ki se uporablja za zdravljenje 5q spinalne mišične atrofije (SMA), genetske bolezni, ki povzroča šibkost in atrofijo mišic, tudi dihalnih.
English: Spinraza has been shown to lead to clinically meaningful improvements in young children with varying degrees of disease severity.
Slovenian: Zdravilo Spinraza je pri majhnih otrocih z različno stopnjo resnosti bolezni pokazalo klinično pomembna izboljšanja.
English: Why is Spinraza approved?
Slovenian: Zakaj je bilo zdravilo Spinraza odobreno?
English: For practical information about using Spinraza, patients should read the package leaflet or contact their doctor or pharmacist.
Slovenian: Za praktične informacije o uporabi zdravila Spinraza naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
English: These side effects are thought to be caused by the injections into the spine used to give the medicine.
Slovenian: Te neželene učinke naj bi povzročale injekcije v hrbtenico, s katerimi se zdravilo daje.
English: Spinraza can only be obtained with a prescription and treatment should be started by a doctor with experience in the treatment of SMA.
Slovenian: Predpisovanje in izdaja zdravila Spinraza je le na recept, zdravljenje pa mora nadzorovati zdravnik, ki ima izkušnje z zdravljenjem SMA.
English: Patients with SMA lack a protein called ‘survival motor neuron' (SMN) protein, which is essential for motor neurons (nerve cells from the spinal cord that control muscle movements) to survive and function normally.
Slovenian: Bolnikom s SMA primanjkuje beljakovine, imenovane „beljakovina preživetja motoričnega nevrona“ (SMN), ki je nujna za preživetje in normalno delovanje motoričnih nevronov (živčnih celic v hrbtenjači, ki nadzorujejo gibe mišic).
English: Patients with SMA lack the SMN1 gene but have the SMN2 gene, which mostly produces a short SMN protein that does not work as well as a full-length protein.
Slovenian: Bolnikom s SMA primanjkuje gena SMN1, gen SMN2 pa imajo, zato se tvori predvsem kratka beljakovina SMN, ki ne deluje enako dobro kot beljakovina s celotno dolžino.