FrancophonIA/ELRC3.0 huggingface dataset:
English: These protocol mandated clinical sign assessments indicate that severe erythema (31%) severe erosions (13%) and severe scabbing and crusting (19%) were very common in these trials with imiquimod cream applied 5 times weekly.
Croatian: Procjena obveznih kliničkih pokazatelja pokazala je da su teški eritem (31%), teške erozije (13%), i teško stvaranje krasti (19%) bili vrlo česti u provedenome ispitivanju u kojemu je imikvimod krema primjenjivana 5 puta tjedno.
English: For imiquimod no clinical data on exposed pregnancies are available.
Croatian: Ne postoje dostupni klinički podaci o izloženim trudnoćama za imikvimod.
English: No clinical experience exists with imiquimod cream immediately following treatment with other cutaneously applied drugs for treatment of external genital or perianal warts.
Croatian: Ne postoji kliničko iskustvo u primjeni imikvimod kreme neposredno nakon provedenog liječenja vanjskih genitalnih i perianalnih bradavica drugim lijekovima koji su se primjenjivali na kožu.
English: Sufficient cream should be applied to cover the treatment area.
Croatian: Potrebno je primijeniti dovoljnu količinu kreme kako bi liječeno područje u potpunosti bilo pokriveno.
English: Actinic keratosis:
Croatian: Aktinična keratoza:
English: Clinical studies investigating the use of imiquimod for the treatment of actinic keratosis have detected a 0.4% (5/1214) frequency of alopecia at the treatment site or surrounding area.
Croatian: Kliničkim ispitivanjima o primjeni imikvimoda u liječenju aktinične keratoze uočena je učestalost ćelavosti na liječenom ili okolnom području od 0,4% (5/1214).
English: Painful skin reactions at the opening of the vagina have very rarely made it difficult for some women to pass urine.
Croatian: U nekih žena su vrlo rijetko bolne kožne reakcije u području otvora vagine otežale izlučivanje urina.
English: No clinical experience exists with the use of imiquimod cream in immunocompromised patients.
Croatian: Nema kliničkih iskustava u primjeni imikvimod kreme u imunokompromitiranih bolesnika.
English: Each sachet contains 12.5 mg of imiquimod in 250 mg cream (5 %).
Croatian: Jedna vrećica sadržava 12,5 mg imikvimoda u 250 mg kreme (5 %).
English: Treatment with imiquimod cream can be resumed after the skin reaction has moderated.
Croatian: Liječenje imikvimod kremom je moguće nastaviti nakon smirivanja kožne reakcije.
English: The results of 3 phase III pivotal efficacy studies showed that treatment with imiquimod for sixteen weeks was significantly more effective than treatment with vehicle as measured by total clearance of treated warts.
Croatian: Rezultati 3 ključna ispitivanja djelotvornosti faze III pokazali su, na temelju potpunog nestanka liječenih bradavica, da je liječenje imikvimodom tijekom 16 tjedana znatno učinkovitije od liječenja podlogom.
English: Apply a thin layer of Aldara cream onto clean, dry wart area and rub gently into the skin until cream vanishes.
Croatian: Nanesite tanak sloj kreme Aldara na čisto i suho područje s bradavicom i nježno utrljavajte dok ju koža ne upije.
English: Remote site skin reactions, mainly erythema (44%), were also reported in the placebo controlled trials.
Croatian: Kožne reakcije na udaljenim mjestima zabilježene su također u placebom kontroliranom ispitivanju, uglavnom eritem (44%).
English: Aldara cream may weaken condoms and diaphragms, therefore the cream should not be left on during sexual activity.
Croatian: Krema Aldara može oslabiti djelovanja kondoma i dijafragmi, stoga uklonite kremu Aldara prije spolnog odnosa.
English: Each sachet contains 250 mg cream (100 mg cream contains 5 mg imiquimod).
Croatian: Svaka vrećica sadržava 250 mg kreme (100 mg kreme sadržava 5 mg imikvimoda).
English: In clinical trials of imiquimod cream 3 times weekly for 4 or 8 weeks the most frequently occurring application site reactions were itching at the target site (14%) and burning at the target site (5%).
Croatian: U kliničkim ispitivanjima primjene imikvimod kreme 3 puta tjedno tijekom 4 tjedna ili 8 tjedana najčešće zapažene reakcije na mjestu primjene bile su svrbež (14%) i pečenje kože (5%).
English: A single-use sachet is sufficient to cover a wart area of 20 cm
Croatian: Vrećica za jednokratnu uporabu dovoljna je za prekrivanje područja veličine 20 cm2.
English: Do not breast-feed your infant during treatment with Aldara cream, as it is not known whether imiquimod is secreted in human milk.
Croatian: Tijekom liječenja kremom Aldara nemojte dojiti budući da nije poznato izlučuje li se imikvimod u majčino mlijeko.
English: Use in children and adolescents is not recommended.
Croatian: Ne preporučuje se primjena kod djece i adolescenata.
English: Very common side effects (likely to occur in more than 1 in 10 patients) Common side effects (likely to occur in fewer than 1 in 10 patients) Uncommon side effects (likely to occur in fewer than 1 in 100 patients) Rare side effects (likely to occur in fewer than 1 in 1,000 patients) Very rare side effects (likely to occur in fewer than 1 in 10,000 patients).
Croatian: Manje česte nuspojave (pojavljuju se kod manje od 1 od 100 bolesnika) Rijetke nuspojave (pojavljuju se kod manje od 1 od 1000 bolesnika)
English: Due to its immunostimulating properties, imiquimod cream should be used with caution in patients who are receiving immunosuppressive medication (see section 4.4).
Croatian: Zbog njezinih imunostimulativnih svojstava imikvimod kremu treba oprezno primjenjivati u bolesnika koji uzimaju imunosupresivne lijekove (vidjeti dio 4.4).
English: During this period, showering and bathing should be avoided.
Croatian: Tijekom tog razdoblja izbjegavajte tuširanje i kupanje.
English: Methyl hydroxybenzoate (E 218) and propyl hydroxybenzoate (E 216) may cause allergic reactions (possibly delayed).
Croatian: Metilparahidroksibenzoat (E 218) i propilparahidroksibenzoat (E 216) mogu uzrokovati alergijske reakcije (moguće i odgođene reakcije preosjetljivosti).
English: Other local reactions such as induration, ulceration, scabbing, and vesicles have also been reported.
Croatian: Druge lokalne reakcije kao što su otvrdnuće, ulceracije, stvaranje krasta i mjehura, također su zabilježene.
English: • Actinic keratosis
Croatian: • aktinične keratoze
English: Many of the undesirable effects of Aldara cream are due to its local action on your skin.
Croatian: Mnoge nuspojave kreme Aldara posljedica su njezina lokalnog djelovanja na kožu.
English: Aldara cream contains methyl hydroxybenzoate, propyl hydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol
Croatian: Aldara krema sadržava metilhidroksibenzoat, propilhidroksibenzoat, cetilni alkohol,stearilni alkohol i benzilni alkohol
English: There was no evidence for serious adverse reaction caused by imiquimod in paediatric patients.
Croatian: Nema dokaza o ozbiljnim nuspojavama pri primjeni imikvimoda u pedijatrijskih bolesnika.
English: Imiquimod cream should be applied prior to normal sleeping hours.
Croatian: Kremu je potrebno primijeniti prije spavanja.
English: The treated AK field was located on the balding scalp or face with a contiguous area of about 40 cm² for both treatment groups presenting with a median number of 7 clinically typical AK lesions at baseline.
Croatian: Liječeno područje zahvaćeno aktiničkom keratozom nalazilo se na proćelavom tjemenu ili na licu, u području od oko 40 cm za obje liječene skupine koje su imale medijan od 7 klinički lezija tipičnih za aktiničnu keratozu na početku ispitivanja.
English: Local skin reactions can be a sign that the drug is working as intended.
Croatian: Lokalne kožne reakcije mogu biti znak djelovanja lijeka.
English: Ear and labyrinth disorders: Tinnitus
Croatian: Poremećaji uha i labirinta tinitus
English: Before going to bed, wash your hands and the treatment area with mild soap and water.
Croatian: Prije spavanja operite ruke i područje liječenja blagim sapunom i vodom te ih temeljito osušite.
English: Imiquimod has the potential to exacerbate inflammatory conditions of the skin.
Croatian: Imikvimod može pogoršati postojeće upalne promjene kože.
English: Topical administration of imiquimod cream resulted in no tumour enhancement at any dose, in comparison with the vehicle cream group.
Croatian: Topikalna primjena imikvimod kreme u bilo kojoj dozi nije dovela do povećanja tumora u usporedbi sa skupinom koja je dobivala podlogu.
English: Apply Aldara cream to the affected area and 1cm (approx. 0.5 inch) around the affected area.
Croatian: Nanesite kremu Aldara na zahvaćeno područje i 1 cm oko zahvaćenog područja.
English: If a skin reaction becomes too uncomfortable during treatment, speak to your doctor.
Croatian: Ako kožna reakcija izazove prekomjernu nelagodu kože, posavjetujte se s liječnikom.
English: If required by the patient's discomfort or the intensity of the local skin reaction, a rest period of several days may be taken.
Croatian: U slučaju nelagode u bolesnika ili intenziteta lokalne kožne reakcije moguća je pauza u liječenju u trajanju od nekoliko dana.
English: Only apply to affected areas and avoid any application on internal surfaces.
Croatian: Kremu primijenite samo na zahvaćeno područje i izbjegavajte unutrašnje površine.
English: Consideration should be given to balancing the benefit of imiquimod treatment for these patients with the risk associated with the possibility of organ rejection or graft-versus-host disease.
Croatian: Kod tih bolesnika potrebno je procijeniti korist od liječenja imikvimodom u odnosu na rizik od mogućeg odbacivanja organa ili pojave reakcije transplantata protiv primatelja.
English: Early signs of stricture may include local skin reactions (e.g. erosion, ulceration, oedema, induration), or increasing difficulty in retracting the foreskin.
Croatian: Rani znakovi strikture uključuju lokalne kožne reakcije (npr. erozije, ulceraciju, edem, otvrdnuće) ili otežano prevlačenje kožice preko glavića penisa.
English: Furthermore, tumours were not seen at any site in a 2-year oral carcinogenicity study in rats.
Croatian: Osim toga, tumori nisu uočeni ni tijekom dvogodišnjeg ispitivanja kancerogenosti kod štakora kod kojih je imikvimod primjenjivan peroralno.
English: The most frequently reported adverse event from these trials judged probably or possibly related to imiquimod cream was application site reactions (22% of imiquimod treated patients).
Croatian: Najčešće prijavljeni štetni događaji tijekom tih ispitivanja koji su ocijenjeni kao vjerojatno ili moguće povezani s liječenjem imikvimod kremom bile su reakcije na mjestu primjene (22% bolesnika liječenih imikvimodom).
English: Blood and lymphatic system disorders:
Croatian: Poremećaji krvi i limfnog sustava limfadenopatija često
English: Imiquimod cream therapy should not be initiated in tissues where open sores or wounds exist until after the area has healed.
Croatian: Terapija imikvimod kremom ne smije se započeti na tkivima s otvorenim ranama sve dok rane u potpunosti ne zacijele.
English: • Do not apply the cream internally.
Croatian: • Krema nije namijenjena primjeni na unutrašnjim površinama.
English: In this latter case, appropriate other measures should be taken.
Croatian: U slučaju infekcije potrebno je poduzeti odgovarajuće mjere.
English: In the pivotal trials with 3 times a week dosing, the most frequently reported adverse drug reactions judged to be probably or possibly related to imiquimod cream treatment were application site reactions at the wart treatment site (33.7% of imiquimod treated patients).
Croatian: U ključnim ispitivanjima primjene kreme 3 puta tjedno najčešće prijavljene nuspojave vjerojatno ili moguće povezane s liječenjem imikvimod kremom bile su reakcije na mjestu primjene na liječenom području s bradavicama (33,7% bolesnika liječenih imikvimodom).
English: In 157 imiquimod-treated male patients, the combined total clearance rate was 23% as compared to 5% in 161 vehicle-treated patients (95%CI for rate difference: 3% to 36%, p<0.001).
Croatian: Kod 157 muškaraca liječenih imikvimodom ukupna stopa potpunog nestanka bradavica bila je 23 % u usporedbi s 5% u 161 bolesnika liječenog podlogom (95% CI za razliku stopa: 3% do 36%, p <0,001).
English: Wash the extra away with mild soap and water.
Croatian: Isperite suvišnu kremu blagim sapunom i vodom.
English: If there is pus (matter) or other suggestion of infection, discuss this with your doctor.
Croatian: Ako se pojavi gnoj ili drugi znak infekcije, posavjetujte se s liječnikom.
English: Serious skin reactions reported from postmarketing experience include erythema multiforme, Stevens Johnson syndrome and cutaneous lupus erythematosus.
Croatian: U kliničkim ispitivanjima zabilježeni su rijetki slučajevi dermatoloških reakcija na lijek na mjestima udaljenim od mjesta primjene, uključujući multiformni eritem, Stevens-Johnsonov sindrom i kožni oblik eritematoznog lupusa.
English: Men with warts under the foreskin should pull the foreskin back each day and wash underneath it.
Croatian: Muškarci s bradavicama ispod kožice penisa moraju svakoga dana povući kožicu i oprati područje ispod nje.
English: Cream
Croatian: Krema
English: Do not use this medication for more than one course if you have problems with your immune system, either due to illness or because of the medicines you are already taking.
Croatian: Ako imate problema s imunološkim sustavom, zbog bolesti ili lijekova koje već uzimate, nemojte primjenjivati ovaj lijek u više od jednog ciklusa liječenja.
English: In those imiquimod patients who achieved total clearance of their warts, the median time to clearance was 8 weeks.
Croatian: U bolesnica liječenih imikvimodom u kojih je zabilježen potpuni nestanak bradavica, medijan vremena do nestanka iznosio je 8 tjedana.
English: 100 mg of cream contains 5 mg of imiquimod.
Croatian: 100 mg kreme sadržava 5 mg imikvimoda.
English: Lymphadenopathy
Croatian: metilparahidroksibenzoat
English: b) Tabular Listing of adverse events:
Croatian: b) Tablični pregled nuspojava:
English: In 119 imiquimod-treated female patients, the combined total clearance rate was 60% as compared to 20% in 105 vehicle-treated patients (95% CI for rate difference: 20% to 61%, p<0.001).
Croatian: Kod 119 žena liječenih imikvimodom ukupna stopa potpunog nestanka bradavica bila je 60% u usporedbi s 20% u 105 bolesnica liječenih podlogom (95% Cl, za razliku stopa: 20% do 61%, p<0,001).
English: A total of 126 of 242 patients treated with imiquimod (52.1%) and 84 of 237 patients treated with topical diclofenac (35.4%) showed complete clinical clearance of the treated AK field at week 20 (i.e. about 8 weeks after the end of the initial treatment cycle); a difference of 16.6% (95% CI: 7.7% to 25.1%).
Croatian: Ukupno 126 od 242 bolesnika liječenih imikvimodom (52,1%) i 84 od 237 bolesnika liječenih topikalnim diklofenakom (35,4%) imalo je potpuno kliničko izlječenje liječenog područja zahvaćenog aktiničnom keratozom u 20. tjednu (tj. oko 8 tjedana nakon završetka početnog ciklusa liječenja); što je razlika od 16,6% (95% CI: 7,7% do 25,1%).
English: There is an association between the complete clearance rate and the intensity of local skin reactions (e.g. erythema).
Croatian: Postoji povezanost između omjera dijela izliječene kože i jačine lokalnih reakcija na koži (npr. eritem).
English: Sachets should not be re-used once opened.
Croatian: Jednom otvorena vrećica ne smije se ponovo upotrijebiti.
English: Rare reports have been received of exacerbation of autoimmune conditions.
Croatian: Rijetko je primijećeno pogoršanje autoimunih bolesti.
English: Regarding the primary endpoint, histological progression, overall 13 of 242 patients (5.4%) of the imiquimod group and 26 of 237 patients (11.0%) of the diclofenac group were found to have a histological progression to in situ or invasive SCC within 3 years, a difference of -5.6% (95% CI: -10.7% to -0.7%).
Croatian: Što se tiče primarne mjere ishoda, histološke progresije, ukupno je kod 13 od 242 bolesnika (5,4%) u skupini liječenoj imikvimodom te 26 od 237 bolesnika (11,0%) u skupini liječenoj diklofenakom zabilježena histološka progresija u in situ ili invazivni karcinom pločastih stanica u roku od 3 godine, što je razlika od -5,6% (95% CI: 10,7% do -0,7%).
English: Commonly some patients (4% or less) have experienced headache, uncommonly fevers and flu like symptoms joint and muscle pains; prolapse of the womb; pain on intercourse in females; erection difficulties; increase in sweating; feeling sick; stomach and bowel symptoms; ringing in the ears; flushing; tiredness; dizziness; migraine; pins and needles; insomnia; depression; loss of appetite; swollen glands; bacterial, viral and fungal infections (e.g. cold sores); vaginal infection including thrush; cough and colds with sore throat.
Croatian: Česte nuspojave su pojava glavobolje (4% bolesnika ili manje), a manje česte su vrućica i simptomi nalik gripi, bol u mišićima i zglobovima, prolaps materice, bol kod žena pri spolnom odnosu, smetnje erekcije, pojačano znojenje, mučnina, simptomi u želucu i debelom crijevu, zujanje u ušima, navale crvenila, umor, omaglica, migrena, trnci i bockanje, nesanica, depresija, gubitak apetita, natečene žlijezde, bakterijske, virusne i gljivične infekcije (npr. herpes na usni), vaginalne infekcije uključujući gljivične infekcije kandidom, kašalj i prehlada s upalom grla.
English: Imiquimod cream should be applied 3 times per week (example: Monday, Wednesday and Friday) for four weeks prior to normal sleeping hours, and left on the skin for approximately 8 hours.
Croatian: Imikvimod kremu je potrebno nanositi 3 puta tjedno (primjerice: ponedjeljak, srijeda i petak) tijekom 4 tjedna prije spavanja i ostaviti da djeluje na koži oko 8 sati.
English: External genital warts, superficial basal cell carcinoma and actinic keratosis:
Croatian: Vanjske genitalne bradavice, površinski bazeocelularni karcinom kože i aktinična keratoza:
English: In those imiquimod patients who achieved total clearance of their warts, the median time to clearance was 12 weeks.
Croatian: U bolesnika liječenih imikvimodom u kojih je zabilježen potpuni nestanak bradavica medijan vremena do nestanka iznosio je 12 tjedana.
English: After a 4-week treatment-free period, clearance of AKs should be assessed.
Croatian: Nakon 4 tjedna bez liječenja potrebno je procijeniti učinak na aktinične keratoze.
English: Eye disorders Conjunctival irritation
Croatian: Poremećaji oka konjuktivalna iritacija edem očnog kapka
English: Patient reported adverse reactions from 2292 patients treated with imiquimod cream in placebo controlled and open clinical studies are presented below.
Croatian: U daljnjem su tekstu navedene nuspojave koje je prijavilo 2292 bolesnika liječenih imikvimod kremom u placebo kontroliranim i otvorenim kliničkim ispitivanjima.
English: Men with warts under the foreskin should pull the foreskin back each day and wash underneath it (see section 2 “Warnings and precautions”)
Croatian: Muškarci s bradavicama ispod kožice penisa moraju svakoga dana povući kožicu i oprati područje ispod nje (pogledajte dio 2.
English: The use of an occlusive dressing is not recommended with imiquimod cream therapy.
Croatian: Primjena okluzivnog zavoja ne preporučuje se tijekom terapije imikvimod kremom.
English: If you experience skin lesions or spots on your skin that start out as small red areas and progress to look like mini targets, possibly with symptoms such as itching, fever, overall ill feeling, achy joints, vision problems, burning, painful or itchy eyes and mouth sores, stop using Aldara cream and tell your doctor immediately.
Croatian: Ako na koži zapazite lezije ili promjene koje su od malih crvenkastih područja razvile karakterističan izgled mete, a mogu biti praćene simptomima kao što su: svrbež , vrućica, opće loše stanje, bol u zglobovima, problemi s vidom, pečenje, bol ili svrbež očiju, ranice u usnoj šupljini, prestanite primjenjivati kremu Aldara i obavijestite o tome svojeg liječnika.
English: • Tell your doctor if you have problems with your immune system.
Croatian: • Ako imate problema s imunološkim sustavom, obavijestite svojeg liječnika.
English: Most skin reactions were mild to moderate in severity and resolved within 2 weeks of treatment discontinuation.
Croatian: Kožne reakcije su većinom bile blage do umjereno teške i nestale su unutar 2 tjedna nakon prestanka liječenja.
English: • Small superficial basal cell carcinomas (sBCCs) in adults.
Croatian: • malih površinskih bazeocelularnih karcinoma kože u odraslih bolesnika.
English: • Superficial basal cell carcinoma.
Croatian: • površinskog bazeocelularnog karcinoma kože.
English: Imiquimod should be used with caution in patients with reduced haematologic reserve (refer to section 4.8d).
Croatian: Potreban je oprez pri primjeni imikvimod kreme u bolesnika sa smanjenom hematološkom rezervom (vidjeti dio 4.8d).
English: See package leaflet for further information.
Croatian: Vidjeti upute o lijeku za dodatne informacije.
English: If required by the patient's discomfort or the severity of the local skin reaction, a rest period of several days may be taken.
Croatian: U slučaju nelagode u bolesnika ili teške lokalne kožne reakcije moguća je pauza u liječenju u trajanju od nekoliko dana.
English: When applied topically, systemic overdosage with imiquimod cream is unlikely due to minimal percutaneous absorption.
Croatian: Pri topikalnoj primjeni imikvimod kreme mala je vjerojatnost sustavnog predoziranja zbog minimalne perkutane apsorpcije.
English: Before applying imiquimod cream, patients should wash the treatment area with mild soap and water and dry thoroughly.
Croatian: Prije primjenjivanja imikvimod kreme područje koje se liječi potrebno je oprati blagim sapunom i vodom i dobro posušiti.
English: Common effects include: pins and needles, small swollen areas in the skin, pain, burning, irritation, bleeding, redness or rash.
Croatian: Česte nuspojave uključuju: trnce i bockanje, manje otoke na koži, bol, pečenje, iritaciju, krvarenje, crvenilo ili osip.
English: You must tell your doctor if you are pregnant or intend to become pregnant.
Croatian: Ako ste trudni ili namjeravate zatrudnjeti, upozorite na to svojeg liječnika.
English: Most of these skin reactions are mild and the skin will return to normal within about 2 weeks after stopping treatment.
Croatian: Većina tih reakcija na koži je blaga i povlači se oko 2 tjedna nakon prekida liječenja.
English: C/Plom, 2-4, 5ª planta 08038 - Barcelona Tel: +34 900 102 712
Croatian: Mylan Pharmaceuticals, S.L. Edificio BerlínC/Plom, 2-4, 5ª planta 208038 - Barcelona Tel: +34 900 102 712
English: Uncommonly some patients experience changes at the application site (bleeding, inflammation, discharge, sensitivity, swelling, small swollen areas in the skin, pins and needles, scabbing, scarring, ulceration or a feeling of warmth or discomfort), or inflammation of the lining of the nose, stuffy nose, flu or flu-like symptoms, depression, eye irritation, swelling of the eyelid, throat pain, diarrhoea, actinic keratosis, redness, swelling of the face, ulcers, pain in extremity, fever, weakness or shivering.
Croatian: Manje česte nuspojave uključuju kod nekih bolesnika reakcije na mjestu primjene kreme (krvarenje, upala, iscjedak, osjetljivost, oticanje, manje otoke na koži, trnce i bockanje, stvaranje krasti, stvaranje ožiljaka, ulceracije ili osjećaj topline ili nelagode) ili upalu sluznice nosa, začepljenje nosa, gripu ili simptome nalik gripi, depresiju, iritaciju oka, oticanje kapaka, bol u grlu, proljev, aktiničnu keratozu, crvenilo, oticanje lica, stvaranje ulkusa (čireva), bol u udovima, vrućicu, slabost ili drhtanje.
English: Apply imiquimod cream for 6 weeks, 5 times per week (example: Monday to Friday) prior to normal sleeping hours, and leave on the skin for approximately 8 hours.
Croatian: Imikvimod kremu je potrebno nanositi tijekom 6 tjedana, 5 puta tjedno (primjerice: od ponedjeljka do petka) prije spavanja i ostaviti da djeluje na koži oko 8 sati.
English: If a dose is missed, the patient should apply the cream as soon as he/she remember and then he/she should continue with the regular schedule.
Croatian: Ako bolesnik propusti primijeniti kremu, potrebno je to učiniti prvom prilikom, a zatim nastaviti primjenu prema redovitom rasporedu.
English: External genital warts:
Croatian: Vanjske genitalne bradavice: