FrancophonIA/ELRC3.0 huggingface dataset:
English: If NUEDEXTA and paroxetine are prescribed concomitantly, the initial dose of paroxetine should be reduced.
Slovenian: Če se sočasno predpiše zdravilo NUEDEXTA in paroksetin, je treba začetni odmerek paroksetina zmanjšati.
English: Quinidine
Slovenian: Kinidin
English: When the urine pH is less than 7, about 20% of administered quinidine appears unchanged in the urine, but this fraction drops to as little as 5% when the urine is more alkaline.
Slovenian: Če je pH urina manj kot 7, se približno 20 % danega kinidina pojavi v urinu v nespremenjeni obliki, ta delež pa pade na 5 %, če je urin bolj bazičen.
English: • excessive muscle stiffness (spasticity)
Slovenian: • prekomerno otrdelost mišic (spastičnost);
English: • bone fractures (skeletal injury)
Slovenian: • zlomi kosti (poškodbe okostja)
English: Anticholinergic effects of quinidine
Slovenian: Antiholinergični učinki kinidina
English: Drug abuse and dependence
Slovenian: Zloraba drog in odvisnost od njih
English: What NUEDEXTA is and what it is used for
Slovenian: Kaj je zdravilo NUEDEXTA in za kaj ga uporabljamo
English: It is not known whether the active substances of NUEDEXTA are expressed into human milk.
Slovenian: Ni znano, ali se zdravilne učinkovine zdravila NUEDEXTA izločajo v človeško mleko.
English: • heart problems, such as slow, fast or irregular heart beat, or altered results during an electrocardiogram (ECG - QT prolongation)
Slovenian: • težave s srcem, npr. počasen, hiter ali nepravilen srčni utrip, ali sprememba rezultatov elektrokardiograma (EKG - podaljšanje intervala QT)
English: There are several hydroxylated metabolites of quinidine.
Slovenian: Obstaja več hidroksiliranih metabolitov kinidina.
English: Nuedexta is suitable only for the treatment of PBA, not for other causes of emotional lability.
Slovenian: Zdravilo Nuedexta je primerno samo za zdravljenje PBP, in ne za druge vzroke čustvene labilnosti.
English: The European Medicines Agency has waived the obligation to submit the results of studies with NUEDEXTA in all subsets of the paediatric population in PBA (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij z zdravilom NUEDEXTA za vse podskupine pediatrične populacije s PBP (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Quinidine clearance is unaffected, although there is an increased volume of distribution that leads to an increase in the elimination half-life.
Slovenian: Na očistek kinidina to ne vpliva, čeprav se pojavi povečan volumen porazdelitve, ki povzroči podaljšanje razpolovnega časa izločanja.
English: The capsule should be taken orally (by mouth) either with or without food at about the same time each day.
Slovenian: Kapsulo vzamete peroralno (jo pojeste) s hrano ali brez nje in ob približno istem času dneva.
English: Other hypersensitivity reactions
Slovenian: Druge preobčutljivostne reakcije
English: When NUEDEXTA is used with other serotoninergic medicines, the risk of “serotonin syndrome” may be increased due to pharmacodynamic interaction.
Slovenian: Če se zdravilo NUEDEXTA uporablja skupaj z drugimi serotoninergičnimi zdravili, se lahko tveganje za „serotoninski sindrom“ poveča zaradi farmakodinamične interakcije.
English: Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na zdravilni učinkovini ali katero koli pomožno snov, navedeno v poglavju 6.1.
English: • loss of appetite (anorexia)
Slovenian: • izguba teka (anoreksija)
English: Hypokalemia and hypomagnesemia should be corrected prior to initiation of therapy, and serum potassium and serum magnesium levels should be monitored during treatment if clinically indicated.
Slovenian: Hipokaliemijo in hipomagneziemijo je treba popraviti pred začetkom zdravljenja, med zdravljenjem pa je treba spremljati ravni kalija in magnezija v serumu, če je to klinično indicirano.
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from NUEDEXTA therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba med prenehanjem dojenja in prenehanjem/prekinitvijo zdravljenja z zdravilom NUEDEXTA, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
English: No other drug interactions with CYP2D6 substrates have been systematically investigated.
Slovenian: Nobenih drugih interakcij s substrati encima CYP2D6 niso proučevali sistematično.
English: • increased liver enzymes (GGT, AST, ALT)
Slovenian: • povišana raven jetrnih encimov (GGT, AST, ALT)
English: • medicines to reduce pain and/or cough, such as codeine and hydrocodone
Slovenian: • zdravila za odpravljanje bolečin in/ali kašlja, npr. kodein in hidrokodon;
English: Patients should be monitored for worsening clinical condition in myasthenia gravis and other conditions that may be adversely affected by anticholinergic effects.
Slovenian: Bolnike je treba spremljati za poslabšanje kliničnega stanja pri miasteniji gravis in drugih stanj, na katera lahko neželeno vplivajo antiholinergični učinki.
English: • Cardiac effects (QT prolongation) including pre-existing cardiovascular conditions and clinically significant electrolyte imbalances
Slovenian: • učinkih na srce (podaljševanje intervala QT), vključno z obstoječimi srčno-žilnimi boleznimi in klinično pomembnimi neravnovesji elektrolitov
English: Likewise, this medicinal product should not be restarted in sensitised patients, because more rapid and more severe thrombocytopenia than the original episode can occur.
Slovenian: Poleg tega se zdravilo ne sme ponovno uvesti pri preobčutljivih bolnikih, saj se lahko pojavi hitrejša in hujša trombocitopenija kot pri prvi epizodi.
English: Please tell your doctor if you are taking any of the following medicines, as your doctor will closely monitor you for side effects.
Slovenian: Obvestite svojega zdravnika, če jemljete katero koli od naslednjih zdravil, saj vas bo zdravnik natančno spremljal glede neželenih učinkov:
English: • From the eighth day of treatment onwards: two capsules per day, one in the morning and one in the evening, 12 hours apart.
Slovenian: • od osmega dne zdravljenja naprej: dve kapsuli na dan, eno vzamete zjutraj, drugo pa zvečer v razmiku 12 ur.
English: Paroxetine exposure (AUC0-24) increased by 1.7 fold and Cmax increased by 1.5 fold.
Slovenian: Izpostavljenost paroksetinu (AUC0-24) se je povečala za 1,7-krat, Cmax.
English: Patients should be warned about the potential for CNS-related effects like somnolence, dizziness and syncope or impaired vision (see section 4.8), and advised not to drive or operate machinery if these symptoms occur.
Slovenian: Bolnike je treba opozoriti na morebitne učinke na osrednje živčevje, kot so somnolenca, omotica ter sinkopa ali poslabšan vid (glejte poglavje 4.8), in jim svetovati, naj ne vozijo ali upravljajo strojev, če se pojavijo ti simptomi.
English: Your doctor will monitor you closely for signs of NUEDEXTA misuse or abuse.
Slovenian: Vaš zdravnik vas bo natančno spremljal za znake napačne uporabe ali zlorabe zdravila NUEDEXTA.
English: The exact mechanism by which dextromethorphan exerts therapeutic effects in patients with pseudobulbar affect is unknown.
Slovenian: Natančni mehanizem, s katerim dekstrometorfan povzroča terapevtske učinke pri bolnikih s psevdobulbarno paralizo, ni znan.
English: Treatment of dextromethorphan overdose should be directed at symptomatic and supportive measures.
Slovenian: Zdravljenje prevelikega odmerjanja dekstrometorfana mora biti usmerjeno na simptomatske in podporne ukrepe.
English: Other medicines and NUEDEXTA
Slovenian: Druga zdravila in zdravilo NUEDEXTA
English: The pharmacokinetics of dextromethorphan/quinidine have not been investigated systematically in elderly subjects (aged >65 years) although such subjects were included in the clinical programme (14% ≥65 years, 2% ≥75 years).
Slovenian: Farmakokinetike dekstrometorfana/kinidina niso sistematično proučevali pri starejših bolnikih (starih > 65 let), čeprav so bili ti preskušanci vključeni v klinični program (14 % ≥ 65 let, 2 % ≥ 75 let).
English: • Serotonin syndrome
Slovenian: • serotoninskim sindromom;
English: • excessively slow or shallow breathing (respiratory depression) and/or turning blue.
Slovenian: • prepočasno ali plitko dihanje (respiratorno depresijo) in/ali pomodrelost.
English: The maximum mean (95% upper confidence bound) difference from placebo after baseline correction was 10.2 (12.6) ms.
Slovenian: Največja povprečna (95-odstotna zgornja meja zaupanja) razlika v primerjavi s placebom po korekciji glede na izhodišče je bila 10,2 (12,6) ms.
English: Interaction with NUEDEXTA may result in an increased effect on QT interval (see sections 4.4 and 4.5).
Slovenian: Interakcija z zdravilom NUEDEXTA lahko poveča učinek na interval QT (glejte poglavji 4.4 in 4.5).
English: These are medicines used to treat malaria or heart rhythm problems.
Slovenian: To so zdravila, ki jih uporabljamo za zdravljenje malarije ali težav s srčnim ritmom;
English: NUEDEXTA can help reduce how often you have episodes of PBA.
Slovenian: Zdravilo NUEDEXTA lahko pomaga zmanjšati pogostnost vaših epizod PBP.
English: The treatment of cardiac effects (haemodynamically unstable polymorphic ventricular tachycardia (including torsades de pointes)) is either immediate cardioversion or immediate overdrive pacing.
Slovenian: Zdravljenje učinkov na srce (hemodinamsko nestabilna polimorfna ventrikularna tahikardija (vključno s torsades de pointes)) vključuje takojšnjo kardioverzijo ali takojšnjo „pospeševalno“ (overdrive) elektrostimulacijo.
English: After administration of the combination product, protein binding remains essentially the same as that after administration of the individual components; dextromethorphan is approximately 60-70% protein bound, and quinidine is approximately 80-89% protein bound.
Slovenian: Po dajanju kombiniranega zdravila ostaja vezava na beljakovine v osnovi enaka kot po dajanju posameznih sestavin; na beljakovine se veže približno 60-70 % dekstrometorfana in 80-89 % kinidina.
English: Take your next dose at the usual time and make sure that approximately 12 hours passes between two doses.
Slovenian: Vzemite naslednji odmerek ob običajnem času in počakajte, da med odmerkoma mine približno 12 ur.
English: NUEDEXTA may be taken without regard to meals as food does not affect the exposure of dextromethorphan and quinidine significantly.
Slovenian: Zdravilo NUEDEXTA je mogoče jemati ne glede na obroke, saj hrana ne vpliva bistveno na izpostavljenost dekstrometorfanu in kinidinu.
English: • very rare (<1/10,000)
Slovenian: • zelo redki (<1/10.000).
English: Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the preceding 14 days due to the risk of serious and possibly fatal drug interactions, including serotonin syndrome.
Slovenian: Bolniki, ki jemljejo zaviralce monoamin-oksidaze (MAOI) ali so jemali zaviralce MAO v preteklih 14 dneh, zaradi tveganja resnih in morebitno smrtnih interakcij med zdravili, vključno s serotoninskim sindromom.
English: As NUEDEXTA may cause harm to your unborn baby, its use is not recommended when you are pregnant or if you are a women of childbearing potential not using contraception.
Slovenian: Ker lahko zdravilo NUEDEXTA škoduje vašemu nerojenemu otroku, njegova uporaba ni priporočljiva, ko ste noseči ali če ste ženska v rodni dobi, ki ne uporablja kontracepcije.
English: Efficacy has only been studied in patients with underlying Amyotrophic Lateral Sclerosis or Multiple Sclerosis (see section 5.1).
Slovenian: Učinkovitost so proučevali samo pri bolnikih, pri katerih je bila osnovna bolezen amiotrofična lateralna skleroza ali multipla skleroza (glejte poglavje 5.1).
English: • you experience symptoms such as palpitations or fainting, which may be a sign of heart problems.
Slovenian: • se pri vas pojavljajo simptomi, kot so palpitacije ali omedlevica, ki so lahko znak težav s srcem;
English: Studies in animals (rats and rabbits) have shown developmental toxicity, including teratogenicity and embryolethality (see section 5.3).
Slovenian: Študije na živalih (podganah in kuncih) so pokazale toksičnost za razvoj, vključno s teratogenostjo in smrtnostjo pri zarodkih (glejte poglavje 5.3).
English: The 12-week open-label phase of the study (during which all subjects received NUEDEXTA 23 mg / 9 mg) showed persistence of the effect observed in the placebo controlled period.
Slovenian: 12-tedenska odprta faza študije (v kateri so vsi preskušanci prejemali zdravilo NUEDEXTA 23 mg/9 mg) je pokazala ohranjanje učinka, ki so ga opazili v obdobju, nadzorovanim s placebom.
English: The first was a 4-week study in PBA subjects with underlying ALS, and the second was a 12-week study in subjects with underlying MS.
Slovenian: Prva študija je bila 4-tedenska študija s preskušanci, ki so imeli PBP in osnovno bolezen ALS, druga pa je bila 12-tedenska študija s preskušanci, ki so imeli osnovno bolezen MS.
English: To evaluate long-term data, 253 subjects who completed the double-blind study phase had the option of entering an open-label extension phase, receiving NUEDEXTA 23 mg /9 mg for another 84 days.
Slovenian: Za oceno dolgoročnih podatkov je imelo 253 preskušancev, ki je zaključilo fazo dvojno slepe študije, možnost vstopa v odprto podaljšano fazo, v kateri so prejemali zdravilo NUEDEXTA 23 mg/9 mg še 84 dni.
English: Strong and moderate CYP3A4 inhibitors should be avoided during treatment with NUEDEXTA.
Slovenian: Močnim in zmernim zaviralcem CYP3A4 se je treba med zdravljenjem z zdravilom NUEDEXTA izogibati.
English: It should not be used if immunemediated thrombocytopenia from structurally related active substances including quinine and mefloquine is suspected, as cross-sensitivity can occur.
Slovenian: Zdravilo se ne sme uporabiti, če obstaja sum na imunsko trombocitopenijo, ki je posledica strukturno sorodnih zdravilnih učinkovin, vključno s kininom in meflokinom, saj se lahko pojavi navzkrižna občutljivost.
English: Drugs that delay elimination of quinidine (cimetidine, carbonic anhydrase inhibitors, thiazide diuretics) should be withdrawn unless absolutely required.
Slovenian: Uporabo zdravil, ki upočasnijo izločanje kinidina (cimetidin, zaviralci karbonske anhidraze, tiazidni diuretiki), je treba prekiniti, razen če je ta nujna.
English: • double vision, blurred vision
Slovenian: • dvojni vid, zamegljen vid
English: If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before taking this medicine.
Slovenian: Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred jemanjem tega zdravila posvetujte z zdravnikom.
English: Both dextromethorphan and memantine are antagonists of the N-methyl-D-aspartate (NMDA) receptor which could theoretically result in an additive effect at NMDA receptors and potentially an increased incidence of adverse reactions.
Slovenian: Dekstrometorfan in memantin sta antagonista receptorjev N-metil-D-aspartata (NMDA), kar lahko teoretično povzroči aditivni učinek na receptorjih NMDA in morebitno povečano pojavnost neželenih učinkov.
English: • atomoxetine, used to treat attention-deficit hyperactivity disorder (ADHD)
Slovenian: • atomoksetin, ki ga uporabljamo za zdravljenje motnje pomanjkanja pozornosti (ADHD);
English: Quinidine is an inhibitor of P-glycoprotein.
Slovenian: Kinidin je zaviralec P-glikoproteina.
English: If patients experience symptoms that could indicate the occurrence of cardiac arrhythmias, e.g. syncope or palpitations, NUEDEXTA should be discontinued pending further evaluation of the patient.
Slovenian: Če se pri bolniku pojavijo simptomi, ki lahko kažejo na pojav srčnih aritmij, npr. sinkopa ali palpitacije, je treba jemanje zdravila NUEDEXTA prekiniti in opraviti dodatno oceno bolnika.
English: Caution should be exercised if patients are treated with concomitant selective serotonin reuptake inhibitors (SSRIs).
Slovenian: Pri bolnikih, ki se sočasno zdravijo s selektivnimi zaviralci ponovnega privzema serotonina (SSRI), je potrebna previdnost.
English: • Educational material for Healthcare Professionals (HCPs)
Slovenian: • izobraževalni material za zdravstvene delavce;
English: The major metabolite is 3-hydroxyquinidine, which is considered to be at least half as pharmacologically active as quinidine with respect to cardiac effects such as QT prolongation.
Slovenian: Glavni metabolit je 3-hidroksikinidin, ki naj bi bil vsaj pol toliko farmakološko aktiven kot kinidin glede učinkov na srce, npr. na podaljšanje intervala QT.
English: • if you take a medicine called thioridazine, which is used for mental illness but can also affect the heart.
Slovenian: • če jemljete zdravilo, imenovano tioridazin, ki ga uporabljamo za zdravljenje duševnih bolezni, lahko pa vpliva tudi na srce;
English: What you need to know before you take NUEDEXTA
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo NUEDEXTA
English: Mild to moderate hepatic impairment had little effect on quinidine pharmacokinetics.
Slovenian: Blaga do zmerna okvara jeter je imela majhen vpliv na farmakokinetiko kinidina.
English: LVH and LVD are more likely to be present in patients with chronic hypertension, known coronary artery disease or history of stroke.
Slovenian: LVH in LVD bosta verjetneje prisotna pri bolnikih s kronično hipertenzijo, potrjeno koronarno boleznijo ali možgansko kapjo v anamnezi.
English: • if you have a history of a liver disease (hepatitis) caused by quinidine
Slovenian: • če ste v preteklosti imeli bolezen jeter (hepatitis), ki jo je povzročil kinidin;
English: A population pharmacokinetic analysis revealed similar pharmacokinetics in patients <65 years and those ≥65 years of age (see section 5.2).
Slovenian: Farmakokinetična analiza populacije je pokazala podobno farmakokinetiko pri bolnikih, starih < 65 let, in bolnikih, starih ≥ 65 let (glejte poglavje 5.2).
English: Patients with moderate hepatic impairment showed an increased frequency of adverse reactions.
Slovenian: Pri bolnikih z zmerno okvaro jeter so opazili povečano pogostnost neželenih učinkov.
English: Lactose warning
Slovenian: Opozorilo o laktozi
English: Use in older persons No special dose adjustment of NUEDEXTA is required in older patients.
Slovenian: Uporaba pri starejših osebah Pri starejših bolnikih niso potrebna posebna prilagajanja odmerkov zdravila NUEDEXTA.
English: Quinidine inhibited CYP2D6 with a half maximal inhibitory concentration (IC50) of less than 0.05 µM.
Slovenian: Kinidin je zaviral CYP2D6 pri polovični najvišji koncentraciji zaviranja (IC50) manj kot 0,05 µM.
English: Administration of activated charcoal in conventional dose of 1 g/kg, administered every 2 to 6 hours as a slurry with 8 mL/kg of tap water may enhance the systemic elimination of quinidine; this measures should be avoided if an ileus is present.
Slovenian: Uporaba aktivnega oglja v običajnem odmerku 1 g/kg, ki se daje vsakih 2-6 ur v obliki mešanice z 8 ml/kg pitne vode, lahko izboljša sistemsko izločanje kinidina; ta ukrep ni primeren, če je prisoten ileus.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redkimi dednimi težavami, kot so intoleranca za galaktozo, laponska oblika zmanjšane aktivnosti laktaze ali malabsorpcija glukoze/galaktoze, tega zdravila ne smejo jemati.
English: If any of the above occur, stop taking the capsules and tell your doctor immediately
Slovenian: Če opazite katerega koli od zgornjih neželenih učinkov, prenehajte jemati kapsule in takoj obvestite svojega zdravnika.
English: Your doctor will start your treatment with NUEDEXTA 15 mg/9 mg capsules which should be taken by you as follows:
Slovenian: Vaš zdravnik bo uvedel zdravljenje z zdravilom NUEDEXTA 15 mg/9 mg kapsule, ki jih morate jemati, kot sledi:
English: Renal clearance involves both glomerular filtration and active tubular secretion, moderated by (pH-dependent) tubular reabsorption.
Slovenian: Ledvični očistek vključuje glomerulno filtracijo in aktivno tubulno sekrecijo, ki ju znižuje (od pH odvisna) tubulna reabsorpcija.
English: Serious adverse reactions have been reported for NUEDEXTA; these are muscle spasticity, respiratory depression and decreased oxygen saturation in the blood.
Slovenian: Pri zdravilu NUEDEXTA so poročali o resnih neželenih učinkih; ti so mišična spastičnost, respiratorna depresija in zmanjšana nasičenost s kisikom v krvi.
English: Dextromethorphan may increase the risk of serotonin syndrome, and this risk is increased by overdose, particularly if taken with other serotonergic agents, SSRIs or tricyclic antidepressants.
Slovenian: Dekstrometorfan lahko poveča tveganje za serotoninski sindrom, to tveganje pa se pri prevelikem odmerjanju še poveča, predvsem v kombinaciji z drugimi serotoninergičnimi učinkovinami, zaviralci SSRI ali tricikličnimi antidepresivi.
English: Therefore, dosage adjustment is not required in patients with mild and moderate hepatic impairment, although additional monitoring for adverse reactions should be considered in patients with moderate hepatic impairment.
Slovenian: Zato pri bolnikih z blago in zmerno jetrno okvaro prilagajanje odmerka ni potrebno, čeprav je treba razmisliti o dodatnem spremljanju za neželene reakcije pri bolnikih z zmerno jetrno okvaro.
English: As this medicinal product may cause foetal harm, it is not recommended during pregnancy and in women of childbearing potential not using contraception.
Slovenian: Ker lahko to zdravilo poškoduje plod, njegova uporaba ni priporočljiva med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo kontracepcije.
English: • if you have a history of a condition called lupus-like syndrome caused by quinidine (this can cause joint pains, skin rash, excessive skin sensitivity to sun and overall feeling of sickness).
Slovenian: • če ste v preteklosti imeli bolezen, imenovano lupusu podoben sindrom, ki ga je povzročil kinidin (ta lahko povzroči bolečine v sklepih, kožni izpuščaj, pretirano občutljivost kože na sonce in splošno slabo počutje);
English: Dextromethorphan is a sigma-1 receptor agonist and an uncompetitive NMDA receptor antagonist.
Slovenian: Dekstrometorfan je agonist receptorjev sigma-1 in nekompetitivni antagonist receptorjev NMDA.
English: Medicinal products that are dependent on CYP2D6 metabolism, especially those with a relatively narrow therapeutic index, should generally be avoided during treatment with NUEDEXTA, and patients must be instructed accordingly.
Slovenian: Zdravilom, ki so odvisna od presnove z encimom CYP2D6, predvsem zdravilom s sorazmerno ozkim terapevtskim indeksom, se je treba med zdravljenjem z zdravilom NUEDEXTA navadno izogibati, o čemer je treba obvestiti tudi bolnika.
English: In addition, the maintenance of the clinical effect of NUEDEXTA in the patient should be regularly monitored in the long-term against its tolerability, in order to ascertain the continued benefit of the product.
Slovenian: Poleg tega je treba zaradi morebitne tolerance redno in dolgoročno spremljati vzdrževanje kliničnega učinka zdravila NUEDEXTA pri bolniku, s čimer se potrdi nenehna korist zdravila.
English: Approximately 30% of study participants carried diagnoses other than ALS and MS, including stroke, traumatic brain injury, Parkinson's disease, Alzheimer's disease and other dementia, primary lateral sclerosis, progressive bulbar palsy, and progressive supranuclear palsy.
Slovenian: Približno 30 % udeležencev študije je imelo diagnozo, ki ni bila ALS ali MS, vključno z možgansko kapjo, travmatsko poškodbo možganov, Parkinsonovo boleznijo, Alzheimerjevo boleznijo in drugimi demencami, primarno lateralno sklerozo, progresivno bulbarno paralizo in progresivno supranuklearno paralizo.