FrancophonIA/ELRC3.0 huggingface dataset:
English: Concentrations of voriconazole may increase or decrease when co-administered with DRV/COBI.
Croatian: Koncentracije vorikonazola mogu se povisiti ili sniziti kada se primjenjuje istodobno s lijekom Symtuza.
English: Based on theoretical considerations DRV/COBI may increase buprenorphine and/or norbuprenorphine plasma concentrations.
Croatian: Na temelju teorijskih razmatranja, DRV/KOBI može povisiti plazmatske koncentracije buprenorfina i/ili norbuprenorfina.
English: Based on theoretical considerations co-administration of DRV/COBI with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Croatian: Na temelju teorijskih razmatranja, istodobna primjena kombinacije DRV/KOBI s ovim antikoagulansima mogla bi povisiti koncentracije antikoagulansa, što može povećati rizik od krvarenja. (inhibicija CYP3A i/ili Pglikoproteina)
English: Refer to the prescribing information for darunavir for further information.
Croatian: Za više informacija vidjeti informacije o lijeku za darunavir.
English: No clinically relevant differences in cobicistat pharmacokinetics were observed between subjects with moderate impairment and healthy subjects.
Croatian: Nisu primijećene klinički značajne razlike u farmakokinetici kobicistata između ispitanika s umjerenim oštećenjem jetrene funkcije i zdravih ispitanika.
English: CORTICOSTEROIDS Budesonide
Croatian: KORTIKOSTEROIDI Budezonid
English: DRV/COBI is expected to increase alfusozin concentrations (CYP3A4 inhibition)
Croatian: Na temelju teorijskih razmatranja očekuje se da će DRV/KOBI povisiti koncentracije alfuzozina (inhibicija CYP3A4)
English: The active substances are darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.
Croatian: Djelatne tvari su darunavir, kobicistat, emtricitabin i tenofoviralafenamid.
English: Therefore, therapy with Symtuza should not be initiated during pregnancy, and women who become pregnant during therapy with Symtuza should be switched to an alternative regimen (see sections 4.4 and 4.6).
Croatian: Stoga se liječenje lijekom Symtuza ne smije započinjati tijekom trudnoće, a žene koje zatrudne tijekom liječenja lijekom Symtuza trebaju prijeći na zamjenski režim (vidjeti dijelove 4.4 i 4.6).
English: Among 1,968 treatment-experienced patients receiving darunavir co-administered with ritonavir 600/100 mg twice daily, 236 patients were co-infected with hepatitis B or C. Co-infected patients were more likely to have baseline and treatment emergent hepatic transaminase elevations than those without chronic viral hepatitis.
Croatian: Od 1968 prethodno liječenih bolesnika koji su primali darunavir istodobno s ritonavirom u dozi od 600/100 mg dvaput na dan, njih 236 bilo je istodobno zaraženo virusom hepatitisa B ili C.
English: - Rifabutin (against bacterial infections) - Tadalafil, sildenafil, vardenafil (for erectile dysfunction or high blood pressure in the pulmonary circulation) - Amitriptyline, desipramine, imipramine, nortriptyline, paroxetine, sertraline, trazodone (to treat depression and anxiety) - Perphenazine, risperidone, thioridazine (psychiatric medicines) - Ciclosporin, everolimus, tacrolimus, sirolimus (for dampening down your immune system) as the therapeutic effect or side effects of these medicines might be increased.
Croatian: Liječnik će procijeniti koji je režim za snižavanje razina kolesterola najbolji za Vas. - rifabutin (za liječenje bakterijskih infekcija) - tadalafil, sildenafil, vardenafil (za liječenje erektilne disfunkcije ili visokog krvnog tlaka u plućnoj cirkulaciji) - amitriptilin, dezipramin, imipramin, nortriptilin, paroksetin, sertralin, trazodon (za liječenje depresije i tjeskobe) - perfenazin, risperidon, tioridazin (psihijatrijski lijekovi) - ciklosporin, everolimus, takrolimus, sirolimus (za potiskivanje imunološkog sustava), zbog mogućeg pojačanja njihova terapijskog učinka ili nuspojava.
English: 111-1921 x 10
Croatian: 6 stanica/mm 3 (raspon 111-1921 x 10
English: If a missed dose is noticed later than 12 hours of the time it is usually taken, it should not be taken and the patient should resume the usual dosing schedule.
Croatian: Ako bolesnik primijeti da je propustio dozu više od 12 sati nakon uobičajenog vremena uzimanja, ne treba uzeti propuštenu dozu, nego nastaviti s primjenom lijeka prema uobičajenom rasporedu.
English: Cross-resistance in HIV-1 infected, treatment-naïve and virologically suppressed patients
Croatian: Križna rezistencija u bolesnika zaraženih virusom HIV-1 koji prethodno nisu bili liječeni i koji su imali virusnu supresiju
English: - Buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem, midazolam when used as an injection (medicines to treat trouble with sleeping or anxiety) - Metformin (to treat type 2 diabetes)
Croatian: „Nemojte kombinirati lijek Symtuza ni s jednim od sljedećih lijekova“ - buspiron, klorazepat, diazepam, estazolam, flurazepam, zolpidem, midazolam kada se koristi u obliku injekcije (lijekovi za liječenje poteškoća sa spavanjem ili tjeskobe) - metformin (za liječenje šećerne bolesti tipa 2)
English: Due to an increase in the unbound darunavir plasma concentrations, Symtuza should be used with caution in patients with mild or moderate hepatic impairment (see sections 4.2, 4.3 and 5.2).
Croatian: U bolesnika s blagim ili umjerenim oštećenjem jetrene funkcije lijek Symtuza treba primjenjivati uz oprez zbog povišenja plazmatskih koncentracija nevezanog darunavira (vidjeti dijelove 4.2, 4.3 i 5.2).
English: Caution is warranted and therapeutic concentration monitoring, if available, is recommended for these antiarrhythmics when co-administered with Symtuza.
Croatian: Kod istodobne primjene antiaritmika i lijeka Symtuza nalaže se oprez, a preporučuje se i terapijsko praćenje koncentracija, ako je ono moguće.
English: Reproductive toxicity studies in rats and rabbits showed no effects on mating, fertility, pregnancy or fetal parameters.
Croatian: Ispitivanja reproduktivne toksičnosti u štakora i kunića nisu pokazala učinke na parenje,
English: Tell your doctor if you take: - Amlodipine, diltiazem, disopyramide, felodipine, flecainide, mexiletine, nicardipine, nifedipine, propafenone, lidocaine, verapamil (for heart disease) as the therapeutic effect or side effects of these medicines may be increased.
Croatian: Obavijestite liječnika ako uzimate: - amlodipin, diltiazem, dizopiramid, felodipin, flekainid, meksiletin, nikardipin, nifedipin,
English: Based on theoretical considerations DRV/COBI may increase the exposure to glecaprevir and pibrentasvir.
Croatian: Temeljeno na teorijskim postavkama DRV/KOBI može povećati izloženost glekapreviru i pibrentasviru.
English: The combination of rifampicin and Symtuza is contraindicated (see section 4.3).
Croatian: Kombinacija rifampicina i lijeka Symtuza je kontraindicirana (vidjeti dio 4.3).
English: No drug interaction trials have been performed using Symtuza.
Croatian: Nisu provedena ispitivanja interakcija lijeka Symtuza s drugim lijekovima.
English: • feeling sick (nausea)
Croatian: • smanjen tek (anoreksija)
English: Included subjects who had ≥ 50 copies/mL in the Week 48/96 window; subjects who discontinued early due to lack or loss of efficacy per investigator's assessment; subjects who discontinued for reasons other than an adverse event (AE), death or lack or loss of efficacy and at the time of discontinuation had a viral value ≥ 50 copies/mL.
Croatian: Dvostrani egzaktni Clopper-Pearsonov interval pouzdanosti 95% CI Uključeni ispitanici koji su imali ≥ 50 kopija/mL u rasponu oko 48./96. tjedna; ispitanici koji su prekinuli ispitivanje prerano radi nedostatka ili gubitka djelotvornosti prema procjeni ispitivača; ispitanici koji su prekinuli ispitivanje zbog drugih razloga osim štetnih događaja, smrti ili nedostatka ili gubitka djelotvornosti, te su u vrijeme prekida imali vrijednost virusnog opterećenja ≥ 50 kopija/mL.
English: HIV-1 RNA < 50 copies/mL CD4+ percent median change from baseline CD4+ cell count mean change from baseline ≥ 1.0 log10 decrease from baseline in plasma viral load
Croatian: HIV-1 RNK < 50 kopija/ml Medijan promjene postotka CD4+ stanica od početne vrijednosti
English: Interactions that have been identified in studies with individual components of Symtuza, i.e. with darunavir (in combination with low dose ritonavir), cobicistat, emtricitabine or tenofovir alafenamide, determine the interactions that may occur with Symtuza.
Croatian: Interakcije koje bi mogle nastupiti kod primjene lijeka Symtuza određene su na temelju interakcija utvrđenih u ispitivanjima pojedinačnih sastavnica lijeka Symtuza, tj. darunavira (u kombinaciji s niskom dozom ritonavira), kobicistata, emtricitabina ili tenofoviralafenamida.
English: The EC50 values for tenofovir alafenamide were in the range of 2.0 to 14.7 nM. Tenofovir alafenamide displayed antiviral activity in cell culture against all HIV-1 groups (M, N, and O), including subtypes A, B, C, D, E, F, and G (EC50 values ranged from 0.10 to 12.0 nM) and showed strain specific activity against HIV-2 (EC50 values ranged from 0.91 to 2.63 nM).
Croatian: Tenofoviralafenamid je u staničnoj kulturi pokazao antivirusnu aktivnost protiv virusa HIV-1 iz svih skupina (M, N i O), uključujući podtipove A, B, C, D, E, F i G (vrijednosti EC50 kretale su se u rasponu od 0,10 do 12,0 µM) i aktivnost protiv određenih sojeva virusa HIV-2 (vrijednosti EC50 kretale su se u rasponu od 0,91 do 2,63 µM).
English: Symtuza should not be used in treatment-experienced patients with one or more DRV-RAMs (see section 5.1) or with HIV-1 RNA ≥ 100,000 copies/mL or CD4+ cell count < 100 cells x 10
Croatian: Bolesnici koji su prethodno primali antiretrovirusnu terapiju Symtuza se ne smije primjenjivati u bolesnika koji su prethodno primali antiretrovirusnu terapiju, a koji imaju jedan ili više DRV-RAM-ova (vidjeti dio 5.1) ili koji imaju HIV-1 RNK > 100 000 kopija/ml ili broj stanica CD4+ < 100 stanica x 10
English: Symtuza 800 mg/150 mg/200 mg/10 mg tablets darunavir/cobicistat/emtricitabine/tenofovir alafenamide
Croatian: Symtuza 800 mg/150 mg/200 mg/10 mg tablete darunavir/kobicistat/emtricitabin/tenofoviralafenamid
English: Therefore, therapy with Symtuza should not be initiated during pregnancy, and women who become pregnant during therapy with Symtuza should be switched to an alternative regimen (see sections 4.2 and 4.4).
Croatian: Stoga se liječenje lijekom Symtuza ne smije započinjati tijekom trudnoće, a žene koje zatrudne tijekom liječenja lijekom Symtuza trebaju prijeći na zamjenski režim (vidjeti dijelove 4.2 i 4.4).
English: Fluticasone
Croatian: Flutikazon
English: You should also not take Symtuza with medicines that contain tenofovir disoproxil (e.g. as fumarate, phosphate, or succinate), lamivudine or adefovir dipivoxil, or medicines that require boosting with ritonavir or cobicistat.
Croatian: Lijek Symtuza nemojte uzimati ni s lijekovima koji sadrže tenofovirdizoproksil (npr. fumarat, fosfat ili sukcinat), lamivudin ili adefovirdipivoksil, kao ni s lijekovima kojima je potrebno pojačanje ritonavirom ili kobicistatom.
English: Based on theoretical considerations DRV/COBI is expected to increase the plasma concentrations of fluvastatin, pitavastatin, pravastatin, lovastatin and simvastatin.
Croatian: Na temelju teorijskih razmatranja, očekuje se da će DRV/KOBI povisiti plazmatske koncentracijefluvastatina, pitavastatina, pravastatina, lovastatina i simvastatina . (inhibicija i/ili prijenos CYP3A)
English: The combination of colchicine and Symtuza is contraindicated in patients with renal or hepatic impairment (see section 4.3).
Croatian: Primjena kolhicina u kombinaciji s lijekom Symtuza kontraindicirana je u bolesnika s oštećenjem bubrežne ili jetrene funkcije (vidjeti dio 4.3).
English: Unlike ritonavir, cobicistat is not an inducer of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or UGT1A1.
Croatian: Za razliku od ritonavira, kobicistat nije induktor CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 ni UGT1A1.
English: - Buprenorphine/naloxone, methadone (medicines to treat opioid dependence) - Salmeterol (medicine to treat asthma) - Artemether/lumefantrine (a combination medicine to treat malaria) - Dasatinib, irinotecan, nilotinib, vinblastine, vincristine (medicines to treat cancer) - Prednisone (corticosteroid) - Sildenafil, tadalafil, vardenafil (for erectile dysfunction or to treat a heart and lung disorder called pulmonary arterial hypertension) - Glecaprevir/pibrentasvir, simeprevir, boceprevir (to treat hepatitis C virus infection).
Croatian: Smiju se koristiti samo nakon medicinske procjene i uz strogi nadzor liječnika zbog mogućih nuspojava povezanih s kortikosteroidima. - buprenorfin/nalokson, metadon (za liječenje opioidne ovisnosti) - salmeterol (za liječenje astme) - artemeter/lumefantrin (kombinirani lijek za liječenje malarije) - dasatinib, irinotekan, nilotinib, vinblastin, vinkristin (za liječenje raka) - prednizon (kortikosteroid) - sildenafil, tadalafil, vardenafil (za erektilnu disfunkciju ili za liječenje srčanog i plućnog poremećaja koji se zove plućna arterijska hipertenzija) - glekaprevir/pibrentasvir, simeprevir, boceprevir (za liječenje infekcije virusom hepatitisa C). - fentanil, oksikodon, tramadol (za liječenje boli) - fesoterodin, solifenacin (liječenje poremećaja mokraćnog sustava).
English: Increased creatine phosphokinase (CPK), myalgia, myositis and rarely, rhabdomyolysis have been reported with the use of HIV protease inhibitors, particularly in combination with NRTIs.
Croatian: Kod primjene inhibitora proteaze HIV-a, osobito u kombinaciji s NRTI-jima, prijavljene su povišene vrijednosti kreatin fosfokinaze (CPK), mialgija, miozitis, a rijetko i rabdomioliza.
English: Symtuza should not be administered concomitantly with medicinal products containing tenofovir disoproxil (e.g. fumarate, phosphate, or succinate), lamivudine, or adefovir dipivoxil used for the treatment of HBV infection.
Croatian: Symtuza se ne smije primjenjivati istodobno s lijekovima koji sadrže tenofovirdizoproksil (npr. fumarat, fosfat ili sukcinat), lamivudin ili adefovirdipivoksil koji se koriste za liječenje HBV infekcije.
English: Hepatobiliary disorders common hepatic enzyme increased uncommon acute hepatitis a, cytolytic hepatitis
Croatian: Poremećaji jetre i žuči često povišene vrijednosti jetrenih enzima manje često akutni hepatitis a, citolitički hepatitis
English: Skin rash may affect more than 1 in 10 patients receiving Symtuza.
Croatian: U više od 1 na 10 bolesnika koji uzimaju lijek Symtuza može se javiti kožni osip.
English: Emerging resistance in HIV-1 infected, treatment-naïve and virologically suppressed patients
Croatian: Pojava rezistencije u bolesnika zaraženih virusom HIV-1 koji prethodno nisu bili liječeni i koji su imali virusnu supresiju
English: Increased monitoring for rifabutin associated adverse reactions including neutropenia and uveitis is warranted due to an expected increase in exposure to rifabutin.
Croatian: S obzirom na očekivano povećanje izloženosti rifabutinu potrebno je pojačano praćenje bolesnika zbog mogućih nuspojava povezanih s rifabutinom, uključujući neutropeniju i uveitis.
English: In patients with advanced liver disease or cirrhosis, treatment discontinuation is not recommended since post-treatment exacerbation of hepatitis may lead to hepatic decompensation.
Croatian: ne preporučuje se prestanak liječenja budući da egzacerbacija hepatitisa nakon liječenja može dovesti do jetrene dekompenzacije.
English: For patients with renal impairment the Summary of Product Characteristics for clarithromycin should be consulted for the recommended dose.
Croatian: Za preporučenu dozu klaritromicina u bolesnika s oštećenjem bubrega vidjeti Sažetak opisa svojstava lijeka za klaritromicin.
English: Tenofovir alafenamide is not an inhibitor of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP2D6 in vitro.
Croatian: Tenofoviralafenamid nije inhibitor CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 ni CYP2D6 in vitro.
English: Based on theoretical considerations, Symtuza is expected to increase the exposure of lomitapide when coadministered.
Croatian: Temeljeno na teorijskim postavkama, očekuje se da će, Symtuza povećati izloženost lomitapidu kada se primjenjuju istodobno. (CYP3A inhibicija)
English: Symtuza might increase the risk for elevated potassium levels by drospirenone.
Croatian: Symtuza može povećati rizik od nastanka povišenih razina kalija radi drospirenona. - budezonid, flutikazon (za kontrolu astme).
English: Symtuza should not be administered concomitantly with medicinal products containing tenofovir disoproxil (as fumarate, phosphate or succinate), lamivudine, or adefovir dipivoxil used for the treatment of HBV infection.
Croatian: Symtuza se ne smije primjenjivati istodobno s lijekovima koji sadrže tenofovirdizoproksil (u obliku fumarata, fosfata ili sukcinata), lamivudin ili adefovirdipivoksil koji se koriste za liječenje HBV infekcije.
English: Darunavir, emtricitabine and tenofovir alafenamide demonstrated additive to synergistic antiviral effects in two-drug combination studies in cell culture.
Croatian: U ispitivanjima kombinacija dvaju lijekova na staničnoj kulturi darunavir, emtricitabin i tenofoviralafenamid pokazali su aditivne do sinergijske antivirusne učinke.
English: Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets darunavir/cobicistat/emtricitabine/tenofovir alafenamide
Croatian: Symtuza 800 mg/150 mg/200 mg/10 mg filmom obložene tablete darunavir/kobicistat/emtricitabin/tenofoviralafenamid
English: Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section 4.4).
Croatian: Tijekom antiretrovirusne terapije može doći do porasta tjelesne težine te povišenja razine lipida i glukoze u krvi (vidjeti dio 4.4).
English: In vitro, tenofovir alafenamide is not metabolised by CYP1A2, CYP2C8, CYP2C9, CYP2C19, or CYP2D6.
Croatian: In vitro se tenofoviralafenamid ne metabolizira putem CYP1A2, CYP2C8, CYP2C9, CYP2C19 ni CYP2D6.
English: Reverse transcriptase
Croatian: Proteaza Reverzna transkriptaza
English: The distribution of tenofovir alafenamide in the body may be affected by the activity of OATP1B1 and OATP1B3.
Croatian: Aktivnost OATP1B1 i OATP1B3 može utjecati na raspodjelu tenofoviralafenamida u tijelu.
English: The concomitante use of Symtuza with these medicinal products is contraindicated (see section 4.3).
Croatian: Istodobna primjena lijeka Symtuza i ovih lijekova je kontraindicirana (vidjeti dio 4.3).
English: Consult the Summary of Product Characteristics for darunavir for further details.
Croatian: Za dodatne informacije vidjeti Sažetak opisa svojstava lijeka za darunavir.
English: Drug-induced hepatitis (e.g. acute hepatitis, cytolytic hepatitis) has been reported with darunavir/ritonavir.
Croatian: Kod liječenja darunavirom/ritonavirom prijavljeni su slučajevi lijekom izazvanog hepatitisa (npr. akutni hepatitis, citolitički hepatitis).
English: Based on theoretical considerations DRV/COBI is expected to increase alfentanil plasma concentrations.
Croatian: Na temelju teorijskih razmatranja, očekuje se da će DRV/KOBI povisiti plazmatske koncentracije alfentanila.
English: Based on theoretical considerations DRV/COBI is expected to increase these antifungal plasma concentrations, and darunavir, cobicistat and/or tenofovir alafenamide plasma concentrations may be increased by the antifungals.
Croatian: Na temelju teorijskih razmatranja, očekuje se da će DRV/KOBI povisiti plazmatske koncentracije ovih antimikotika, a antimikotici mogu povisiti plazmatske koncentracije darunavira, kobicistata i/ili tenofoviralafenamida. (inhibicija CYP3A i/ili P-glikoproteina)
English: It is important to talk to your doctor if you develop a rash.
Croatian: Važno je da u slučaju pojave osipa razgovarate s liječnikom.
English: Dihydroergotamine Ergometrine
Croatian: Dihidroergotamin Ergometrin
English: Rifampicin to treat some infections such as tuberculosis Pimozide, lurasidone, quetiapine or sertindole to treat psychiatric conditions Ergot alkaloids like ergotamine, dihydroergotamine, ergometrine and methylergonovine to treat migraine headaches
Croatian: karbamazepin, fenobarbital i fenitoin za sprječavanje napadaja kolhicin (ako imate tegobe s bubrezima/jetrom) za liječenje gihta kombinirani lijek lopinavir/ritonavir lijek protiv HIV-a rifampicin za liječenje nekih infekcija poput tuberkuloze pimozid, lurazidon, kvetiapin ili sertindol za liječenje psihijatrijskih bolesti alkaloidi ergota kao što su ergotamin, dihidroergotamin, ergometrin i metilergonovin za liječenje migrenskih glavobolja gospina trava (Hypericum perforatum)
English: The concomitant use of Symtuza with alfusozin is contraindicated (see section 4.3).
Croatian: Istodobna primjena lijeka Symtuza i alfuzozina je kontraindicirana (vidjeti dio 4.3).
English: Based on theoretical consideration, St. John's wort may substantially decrease DRV/COBI (CYP3A4 induction) and TAF exposures.
Croatian: Na temelju teorijskih razmatranja, gospina trava može značajno sniziti izloženost kombinaciji DRV/KOBI (indukcija CYP3A4) i tenofoviralafenamidu. (indukcija P-glikoproteina)
English: HIV-1 Treatment experienced Patients
Croatian: Bolesnici koji su prethodno liječeni zbog HIV-1
English: (CYP3A inhibition) Co-administration of ciclosporin is expected to increase plasma concentrations of tenofovir alafenamide.
Croatian: Očekuje se da će istodobna primjena ciklosporina povisiti plazmatske koncentracije tenofoviralafenamida. (inhibicija P-glikoproteina)
English: Patients with co-existing conditions
Croatian: Bolesnici s popratnim bolestima
English: Prior data with ritonavir-boosted darunavir however showed a decrease in these anti-depressant plasma concentrations (unknown mechanism); the latter may be specific to ritonavir.
Croatian: Na temelju teorijskih razmatranja, očekuje se da će DRV/KOBI povisiti plazmatske koncentracije ovih antidepresiva. (inhibicija CYP2D6 i/ili CYP3A) Međutim, prijašnji podaci koji se odnose na darunavir pojačan ritonavirom pokazali su sniženje plazmatskih koncentracija ovih antidepresiva (mehanizam nepoznat); potonje bi moglo biti specifično za ritonavir.
English: The combination of avanafil and Symtuza is contraindicated (see section 4.3).
Croatian: Kombinacija avanafila i lijeka Symtuza je kontraindicirana (vidjeti dio 4.3).
English: For more information consult the cobicistat Summary of Product Characteristics.
Croatian: Za više informacija vidjeti Sažetak opisa svojstava lijeka za kobicistat.
English: All components were rapidly absorbed following oral administration of Symtuza in healthy subjects.
Croatian: Nakon peroralne primjene lijeka Symtuza u zdravih ispitanika sve su se sastavnice brzo apsorbirale.
English: - Bosentan (to treat high blood pressure in the pulmonary circulation) - Apixaban, edoxaban, rivaroxaban (to reduce clotting of the blood) as their therapeutic effect or side effects may be altered.
Croatian: propafenon, lidokain, verapamil (za liječenje srčane bolesti), zbog mogućeg pojačanja njihova terapijskog učinka ili nuspojava - bosentan (za liječenje visokog krvnog tlaka u plućnoj cirkulaciji) - apiksaban, edoksaban, rivaroksaban (smanjuju zgrušavanje krvi), zbog mogućih promjena njihova terapijskog učinka ili nuspojava. - klonazepam (za sprječavanje napadaja).
English: In vitro studies have shown that tenofovir alafenamide is metabolised to tenofovir (major metabolite) by cathepsin A in PBMCs (including lymphocytes and other HIV target cells) and macrophages; and by carboxylesterase-1 in hepatocytes.
Croatian: A u mononuklearnim stanicama periferne krvi (uključujući limfocite i druge ciljne stanice HIV-a) i makrofagima te uz pomoć karboksilesteraze-1 u hepatocitima.
English: Concomitant use of Symtuza with lovastatin and simvastatin is contraindicated (see section 4.3).
Croatian: Istodobna primjena lijeka Symtuza s lovastatinom i simvastatinom je kontraindicirana (vidjeti dio 4.3).
English: It is used in adults and adolescents aged 12 years and older who weigh at least 40 kg. Symtuza contains four active substances:
Croatian: Koristi se u odraslih i adolescenata u dobi od 12 godina i starijih, tjelesne težine najmanje 40 kg.
English: Co-administration of Symtuza and ergot derivatives is contraindicated (see section 4.3).
Croatian: Istodobna primjena lijeka Symtuza i derivata ergota je kontraindicirana (vidjeti dio 4.3).