FrancophonIA/ELRC3.0 huggingface dataset:
English: The incidence of hepatic transaminase increases was greater in patients receiving Plegridy compared to placebo.
Croatian: Incidencija povećanih razina jetrenih transaminaza bila je veća u bolesnika koji su primali Plegridy u usporedbi s placebom.
English: If TMA is diagnosed, prompt treatment is required (considering plasma exchange) and immediate discontinuation of Plegridy is recommended.
Croatian: Ako se dijagnosticira TMA, potrebno je hitno započeti liječenje (razmotriti plazmaferezu) i preporučuje se odmah prekinuti liječenje Plegridyjem.
English: If it is not clear if Plegridy has been stored at room temperature 30 days or more, it should be discarded.
Croatian: Ako nije poznato je li Plegridy bio čuvan na sobnoj temperaturi 30 dana ili više, mora se baciti.
English: What Plegridy is and what it is used for 2.
Croatian: Što je Plegridy i za što se koristi 2.
English: • You do not see the green stripes in the injection status window.
Croatian: • ako ne vidite zelene pruge u prozorčiću stanja injekcije
English: Step 8: Check to make sure you received your full dose of Plegridy (see Figure J)
Croatian: 8. korak: Provjerite kako biste bili sigurni da ste primili cijelu dozu Plegridyja (pogledajte sliku J) a.
English: You could get a needle injury or the pen may lock.
Croatian: Mogli biste se ubosti ili bi se brizgalica mogla zaključati.
English: Remove your Plegridy pack from the fridge and select the appropriate pen (dosage) from the pack.
Croatian: Izvadite iz hladnjaka pakiranje Plegridyja i odaberite odgovarajuću brizgalicu (veličinu doze)
English: • Check that your Plegridy medicine is clear and colourless (See Figure D).
Croatian: • Provjerite da je lijek Plegridy bistar i bezbojan (pogledajte sliku D).
English: Peginterferon beta-1a was not mutagenic when tested in an in vitro bacterial reverse mutation (Ames) test and was not clastogenic in an in vitro assay in human lymphocytes.
Croatian: Peginterferon beta-1a nije bio mutagen kada se testirao u in vitro testu bakterijske reverzne mutacije (Ames) i nije bio klastogen u in vitro testu s ljudskim limfocitima.
English: Elevations of serum hepatic transaminases combined with elevated bilirubin were observed in two patients who had pre-existing liver test abnormalities prior to receiving Plegridy in the clinical trials.
Croatian: Povišenja serumskih jetrenih transaminaza u kombinaciji s povišenim bilirubinom zabilježeno je u dva bolesnika koji su imali abnormalnosti jetrenih testova već i prije primanja Plegridyja u kliničkim ispitivanjima.
English: Re-capping could cause the pen to lock.
Croatian: Ponovno stavljanje kapice može dovesti do zaključavanja brizgalice.
English: Symptoms may include increased bruising, bleeding, fever, extreme weakness, headache, dizziness or light-headedness.
Croatian: Simptomi mogu uključivati povećano stvaranje modrica, krvarenje, vrućicu, iznimnu slabost, glavobolju, omaglicu ili ošamućenost.
English: The observed Cmax (mean±SE) was 280 ± 79 pg/mL following repeat dosing of 125 micrograms every two weeks.
Croatian: (srednja vrijednost ± SE) bila je 280 ± 79 pg/ml nakon ponovljenog doziranja od 125 mikrograma svaka dva tjedna.
English: *Class label for interferon beta products (see section 4.4).
Croatian: *Značajka skupine lijekova koji sadrže interferon beta (vidjeti dio 4.4).
English: a. Check the injection status window.
Croatian: Provjerite prozorčić stanja injekcije.
English: Patients should be advised to discontinue Plegridy and seek immediate medical care if they experience signs and symptoms of anaphylaxis or severe hypersensitivity.
Croatian: Bolesnicima treba savjetovati da prekinu primjenu Plegridyja i odmah zatraže liječničku pomoć ako opaze znakove i simptome anafilaksije ili teške preosjetljivosti.
English: Whether the mechanism of action of Plegridy in MS is mediated by the same pathway(s) as the biological effects described above is not known because the pathophysiology of MS is only partially understood.
Croatian: Nije poznato je li mehanizam djelovanja Plegridyja u MS-u isti kao prethodno opisan slijed bioloških učinka, jer patofiziologija MS-a nije u potpunosti razjašnjena.
English: Of the patients who experienced injection site reactions 95% reported them as mild or moderate in severity.
Croatian: Od bolesnika koji su prijavili reakcije na mjestu injiciranja 95% ih je prijavilo kao blage ili umjerene težine.
English: Note: • Before you use the Plegridy pre-filled syringe for the first time, your doctor or nurse should show you or your carer how to prepare and inject the Plegridy pre-filled syringe.
Croatian: Napomena: • Prije nego što prvi put upotrijebite napunjenu štrcaljku Plegridyja, liječnik ili medicinska sestra moraju Vama ili Vašem njegovatelju pokazati kako pripremiti i ubrizgati Plegridy iz napunjene štrcaljke.
English: Plegridy should be administered with caution to patients with a history of seizures, to those receiving treatment with anti-epileptics, particularly if their epilepsy is not adequately controlled with anti-epileptics (see section 4.8).
Croatian: Plegridy treba s osobitom pozornošću davati bolesnicima koji su već imali epileptičke napadaje, bolesnicima koji se liječe antiepilepticima, posebno ako njihova epilepsija nije prikladno kontrolirana antiepilepticima (vidjeti dio 4.8).
English: Plegridy has no or negligible influence on the ability to drive and use machines.
Croatian: Upravljanje vozilima i strojevima Plegridy ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: You should see green ticks.
Croatian: Morate vidjeti zelene kvačice.
English: • You should hold the pen over your injection site at 90o angle.
Croatian: • Brizgalicu morate držati iznad mjesta za injekciju pod kutom od 90o.
English: Nephrotic syndrome (class effects)
Croatian: Nefrotski sindrom (učinak skupine lijekova)
English: Proportion with 12 week confirmed disability progression*
Croatian: Udio s potvrđenom progresijom onesposobljenosti u 12. tjednu*
English: b. Check the expiry date.
Croatian: b. Provjerite datum isteka roka valjanosti.
English: Serious hypersensitivity reactions including cases of anaphylaxis have been reported as a rare complication of treatment with interferon beta, including Plegridy.
Croatian: Ozbiljne reakcije preosjetljivosti, uključujući slučajeve anafilaksije, prijavljene su kao rijetka komplikacija liječenja interferonom beta, uključujući i Plegridy.
English: What you need to know before you use Plegridy Do not use Plegridy
Croatian: Što morate znati prije nego počnete primjenjivati Plegridy Nemojte primjenjivati Plegridy
English: Step 5: Firmly remove the needle cover
Croatian: 5. korak: Jednim čvrstim potezom skinite pokrov igle
English: If Plegridy is at room temperature for a total of 30 days, it should be used or discarded.
Croatian: Ako se Plegridy čuvao na sobnoj temperaturi ukupno 30 dana, mora se upotrijebiti ili baciti.
English: Peginterferon beta-1a is a modified long-acting form of interferon.
Croatian: Peginterferon beta-1a je modificirani oblik interferona s dugotrajnim djelovanjem.
English: In the clinical study conducted, the development of antibodies against the PEG moiety of peginterferon beta-1a had no discernible impact on safety, or clinical efficacy (including annualised relapse rate, MRI lesions, and disability progression).
Croatian: U provedenom kliničkom ispitivanju razvoj protutijela protiv PEG skupine peginterferona beta-1a nije imao zamjetan utjecaj na sigurnost ili kliničku djelotvornost (uključujući godišnju stopu recidiva, MR lezije i progresiju onesposobljenosti (invalidnosti).
English: Biological effects that may be mediated by Plegridy include up-regulation of anti-inflammatory cytokines (e.g. IL-4, IL-10, IL-27), down-regulation of pro-inflammatory cytokines (e.g. IL-2, IL-12, IFN-γ, TNF-α) and inhibiting the migration of activated T cells across the blood brain barrier; however additional mechanisms may be involved.
Croatian: Biološki učinci koji mogu biti posredovani Plegridyjem, uključuju povećanu ekspresiju protuupalnih citokina (npr. IL-4, IL-10, IL-27), smanjenu ekspresiju proupalnih citokina (npr. IL-2, IL-12, IFNγ, TNFα) i inhibiciju migracije aktiviranih T stanica preko krvno-moždane barijere; no mogu biti uključeni i dodatni mehanizmi.
English: You should see green stripes.
Croatian: Trebali biste vidjeti zelene pruge.
English: Headache, dizziness or light-headedness
Croatian: - glavobolja, omaglica ili ošamućenost
English: rash or colour change - Changes in your blood which might cause tiredness or reduced ability to fight infection - Increases in liver enzymes in the blood (will show up in blood tests)
Croatian: - promjene u krvi koje mogu uzrokovati umor ili smanjenu sposobnost obrane protiv infekcija - povećanje jetrenih enzima u krvi (pokazat će se u krvnim pretragama)
English: If you remove the cap, do not recap the pen.
Croatian: Ako skinete kapicu, nemojte je vraćati na brizgalicu.
English: - Contact a doctor as they may be signs of a possible kidney problem.
Croatian: Obratite se liječniku jer to mogu biti znakovi mogućih tegoba s bubrezima.
English: - Hypersensitivity to natural or recombinant interferon beta or peginterferon or to any of the excipients listed in section 6.1.
Croatian: - Preosjetljivost na prirodni ili rekombinantni interferon beta, peginterferon ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: In animals, anovulatory effects were observed at very high doses (see section 5.3).
Croatian: U vrlo visokim dozama prilikom testiranja na životinjama primijećen je anovulatorni učinak (vidjeti dio 5.3).
English: CI: Confidence interval * Sustained disability progression was defined as at least a 1 point increase from baseline EDSS ≥ 1 or 1.5 point increase for patients with baseline EDSS of 0, sustained for 12 / 24 weeks.
Croatian: * Kontinuirana progresija onesposobljenosti definirana je kao povećanje početnog EDSS ≥1 za najmanje 1 bod ili 1,5 bodova povećanja za bolesnike s početnim EDSS=0, održano kroz 12/24 tjedna.
English: Worsening of cardiac disease has been reported in patients receiving interferon beta.
Croatian: Pogoršanja srčanih bolesti zabilježena su u bolesnika koji primaju interferon beta.
English: This disrupts the messages between the brain and other parts of the body, causing the symptoms of MS.
Croatian: Kad se mijelin ošteti, prijenos poruka između mozga i ostalih dijelova tijela se poremeti uzrokujući simptome multiple skleroze.
English: With your other hand, firmly grasp needle cover and pull it straight off the needle (See Figure F).
Croatian: Drugom rukom čvrsto uhvatite pokrov igle i povucite ga ravno s igle (pogledajte sliku F).
English: Accordingly, the half-life (t1/2) of peginterferon beta-1a is approximately 2-fold longer than non-pegylated interferon beta-1a in healthy volunteers.
Croatian: U skladu s tim, poluvijek (t1/2) peginterferona beta-1a je oko 2 puta dulji nego poluvijek nepegiliranog interferona beta-1a u zdravih dobrovoljaca.
English: The process of covalently conjugating a PEG moiety to a protein can alter the in vivo properties of the unmodified protein, including decreased renal clearance and decreased proteolysis thus extending the circulating half-life.
Croatian: Postupak kovalentnog vezanja PEG skupine na protein može mijenjati in vivo svojstva nemodificiranog proteina, uključujući smanjenje bubrežnog klirensa i smanjenu proteolizu čime se produljuje njegov poluvijek u cirkulaciji.
English: However, results from a population pharmacokinetic analysis (in patients up to 65 years) suggest that age does not impact peginterferon beta-1a clearance.
Croatian: Međutim, rezultati populacijske farmakokinetičke analize (u bolesnika do 65 godina) ukazuju na to da dob ne utječe na klirens peginterferona beta-1a.
English: Read the instructions for use before you start using Plegridy and each time you get a refill of your prescription.
Croatian: Pročitajte upute za uporabu prije nego što počnete koristiti Plegridy i svaki put kada ponovno dobijete lijek na recept jer mogu sadržavati nove informacije.
English: b. Wipe your skin with an alcohol wipe.
Croatian: Obrišite kožu vatom natopljenom alkoholom.
English: Plegridy can be used during breastfeeding.
Croatian: Plegridy se može koristiti tijekom dojenja.
English: External heat sources such as hot water must not be used to warm Plegridy.
Croatian: Vanjski izvori topline poput vruće vode ne smiju se koristiti za zagrijavanje Plegridyja.
English: The pharmacological properties of Plegridy are consistent with those of interferon beta-1a and are believed to be mediated by the protein portion of the molecule.
Croatian: Farmakološka svojstva Plegridyja u skladu su s onima interferona beta-1a i vjeruje se da su posredovana proteinskim dijelom molekule.
English: Your doctor may want to check your blood pressure, blood (platelet count) and the function of your kidneys.
Croatian: Liječnik će Vam možda htjeti provjeriti krvni tlak, provesti krvne pretrage (broj trombocita) i provjeriti funkciju bubrega.
English: Step 2: Collect your supplies and wash your hands.
Croatian: 2. korak: Prikupite pribor i operite ruke a.
English: This could lock the pen
Croatian: To bi moglo zaključati brizgalicu.
English: Pharmacokinetics observed in multiple sclerosis patients were consistent with those seen in healthy subjects.
Croatian: Farmakokinetika opažena u bolesnika s multiplom sklerozom bila je dosljedna farmakokinetici opaženoj kod zdravih ispitanika.
English: Step 11: Check your injection site
Croatian: 11. korak: Pregledajte mjesto injekcije
English: 1285 patients received at least 1 year, 1124 patients have received at least 2 years, 947 patients received at least 3 years, and 658 patients received at least 4 years of treatment with Plegridy.
Croatian: Od toga je 1285 bolesnika bilo liječeno Plegridyjem najmanje 1 godinu, 1124 bolesnika najmanje 2 godine, 947 bolesnika najmanje 3 godine, a 658 bolesnika najmanje 4 godine.
English: Data from patients treated up to 2 years with Plegridy suggests that less than 1% (5/715) developed persistent-neutralising antibodies to the interferon beta-1a portion of peginterferon beta-1a.
Croatian: Podaci bolesnika koji su liječeni do 2 godine Plegridyjem pokazuju da je manje od 1% (5/715) razvilo perzistentna neutralizirajuća protutijela na interferon beta-1a u peginterferonu beta-1a.
English: Patients should be advised to immediately report any symptoms of depression and/or suicidal ideation to their prescribing physician.
Croatian: Bolesnike je potrebno savjetovati da odmah prijave svom liječniku bilo koji simptom depresije i/ili suicidalnih ideacija.
English: Of the patients who reported flu-like symptoms 90% reported them as mild or moderate in severity.
Croatian: Od bolesnika koji su prijavili simptome nalik gripi, 90% ih je prijavilo kao simptome blage ili umjerene težine.
English: • Gently pinch the skin around the cleaned injection site using thumb and forefinger to create a slight bulge (See Figure G).
Croatian: • Nježno stisnite kožu oko očišćenog mjesta za injekciju koristeći palac i kažiprst tako da se odigne u nabor (pogledajte sliku G).
English: • After the needle is in, let go of your skin.
Croatian: • Nakon uvođenja igle u nabor možete otpustiti kožu.
English: • Plegridy pre-filled syringe should be injected into the abdomen, thigh, or the back of the upper arm. (See Figure E).
Croatian: • Plegridy u napunjenoj štrcaljki treba ubrizgati u trbuh, natkoljenicu ili stražnju stranu nadlaktice (pogledajte sliku E).
English: Do not inject into an area of your body where the skin is irritated, red, bruised, tattooed, infected, or scarred.
Croatian: Nemojte ubrizgati lijek u područje tijela gdje je koža nadražena, osjetljiva, crvena, inficirana ili prekrivena modricama, tetovažama ili ožiljcima.
English: Plegridy is for subcutaneous use.
Croatian: Plegridy je namijenjen za supkutanu primjenu.
English: - For patients with ≥2 relapses in the previous year and at least 1 Gd+ lesion (n=273), the annual relapse rate at 1 year was 0.47 for placebo, 0.35 for Plegridy every 4 weeks, and 0.33 for Plegridy every 2 weeks.
Croatian: - Za bolesnike s ≥2 relapsa u prethodnoj godini i najmanje 1 Gd+ lezijom (n=273), godišnja je stopa relapsa nakon 1 godine bila 0,47 za placebo, 0,35 za Plegridy svaka 4 tjedna i 0,33 za Plegridy svaka 2 tjedna.
English: • Keep Plegridy pen and all medicines out of reach of children.
Croatian: • Čuvajte brizgalicu Plegridy i sve lijekove izvan dohvata djece.
English: Day 14 (94 micrograms)
Croatian: 14. dan (94 mikrograma)
English: In both patients, cell counts recovered after discontinuation of Plegridy.
Croatian: U oba bolesnika, broj stanica se oporavio nakon prekida liječenja Plegridyjem.
English: • Slowly push the plunger all the way down until syringe is empty (See Figure I).
Croatian: • Polagano pritišćite klip sve do kraja dok se štrcaljka ne isprazni (pogledajte sliku I).
English: Urinary (renal) clearance is postulated to be a major excretory pathway for Plegridy.
Croatian: Pretpostavlja se da je urinarni (renalni) klirens glavni put izlučivanja Plegridyja.
English: Choose the correct syringe from a pack.
Croatian: Odaberite ispravnu štrcaljku iz pakiranja.
English: • Remove one Plegridy pack out of the fridge and select the appropriate pre-filled syringe from the pack.
Croatian: • Izvadite iz hladnjaka jedno pakiranje Plegridyja i odaberite odgovarajuću napunjenu štrcaljku iz pakiranja.
English: However, the development of antibodies against the interferon moiety of peginterferon beta-1a had no discernible impact on safety or clinical efficacy, although the analysis was limited by the low immunogenicity incidence.
Croatian: Međutim, razvoj protutijela protiv interferona u peginterferonu beta-1a nije imao zamjetan učinak na sigurnost i kliničku djelotvornost, iako je analiza bila ograničena niskom incidencijom imunogenosti.
English: Use the record table printed on the inside of the lid of the Initiation Pack to keep a track of your injection dates.
Croatian: Koristite tablicu za bilježenje koja je otisnuta na unutarnjem dijelu poklopca pakiranja za početak liječenja kako biste vodili evidenciju o datumima davanja injekcija.
English: • Each Plegridy pre-filled syringe can be used once only.
Croatian: • Jedna napunjena štrcaljka Plegridyja smije se upotrijebiti samo jedanput.
English: Three percent of patients (18/681) developed persistent antibodies to the PEG moiety of peginterferon beta-1a.
Croatian: U 3% bolesnika (18/681) razvila su se perzistentna protutijela na PEG skupinu u peginterferonu beta-1a.
English: • Check with your doctor, pharmacist or nurse about the right way to throw away the used syringe.
Croatian: • Provjerite s liječnikom, ljekarnikom ili medicinskom sestrom kako na ispravan način baciti upotrijebljenu štrcaljku.
English: • Using one hand, hold the syringe by the glass barrel.
Croatian: • Jednom rukom držite štrcaljku za stakleno tijelo.
English: The duration of this response was sustained and prolonged for Plegridy, with elevations detected up to 15 days compared to 4 days for non-pegylated interferon beta-1a.
Croatian: Trajanje tog odgovora bilo je održano i produljeno za Plegridy, s povišenjima detektiranim do 15 dana u odnosu na 4 dana za nepegilirani interferon beta-1a.
English: Thrombotic microangiopathy (TMA) (class effects)
Croatian: Trombotička mikroangiopatija (TMA) (učinak skupine lijekova)
English: Two serious cases were reported in patients treated with Plegridy: one patient (<1%) experienced severe thrombocytopenia (platelet count <10 x 109/L), another patient (<1%) experienced severe neutropenia (neutrophil count <0.5 x 109/L).
Croatian: Dva ozbiljna slučaja zabilježena su u bolesnika liječenih Plegridyjem: jedan bolesnik (<1%) doživio je tešku trombocitopeniju (broj trombocita <10 x 109/l), a drugi bolesnik (<1%) razvio je tešku neutropeniju (broj neutrofila <0,5 x 109/l).
English: Decreases in white blood cell counts of <3.0 x 109/L were observed in 7% of patients receiving Plegridy and in 1% receiving placebo.
Croatian: Smanjenja broja bijelih krvnih stanica od <3,0 x 109/l opažena su u 7% bolesnika koji su primali Plegridy i u 1% koji su primali placebo.
English: Plegridy pre-filled pen must not be used unless the green stripes are visible in the pen injection status window.
Croatian: Plegridy u napunjenoj brizgalici ne smije se koristiti ako zelene trake nisu vidljive u prozorčiću statusa injekcije u napunjenoj brizgalici.
English: Plegridy every 2 weeks significantly reduced the annualized relapse rate (ARR) by 36% compared to placebo (p=0.0007) at one year (Table 3) with consistent reductions of the ARR noted in subgroups defined by demographic and baseline disease characteristics.
Croatian: Plegridy davan svaka 2 tjedna značajno je smanjio godišnju stopu relapsa (ARR) za 36% u odnosu na placebo (p = 0,0007) nakon jedne godine (tablica 3), s dosljednim smanjenjima ARR opaženima u podskupinama definiranim demografskim obilježjima i obilježjima bolesti na početku ispitivanja.
English: Cardiac disease
Croatian: Bolesti srca
English: The available information on the effects of interferon beta-1a in the peri- and postnatal periods is limited.
Croatian: Dostupni podaci o učincima interferona beta-1a u pre i postnatalnom razdoblju su ograničeni.
English: Treatment initiation
Croatian: Započinjanje liječenja
English: Very common (≥1/10) Common (≥1/100 to <1/10) Uncommon (≥1/1, 000 to <1/100) Rare (≥1/10, 000 to <1/1,000)
Croatian: Učestalost nuspojava u nastavku razvrstana je prema sljedećim kategorijama: vrlo često (≥1/10) često (≥1/100 i <1/10) manje često (≥1/1000 i <1/100) rijetko (≥1/10 000 i <1/1000) vrlo rijetko (<1/10 000) nepoznato (ne može se procijeniti iz dostupnih podataka)
English: Laboratory abnormalities are associated with the use of interferons.
Croatian: Abnormalnosti u laboratorijskim nalazima povezane su s primjenom interferona.
English: • After 2 hours, check the injection site for redness, swelling, or tenderness.
Croatian: • Nakon 2 sata provjerite je li mjesto injekcije crveno, otečeno, ili osjetljivo.
English: Each haemodialysis reduced peginterferon beta-1a concentration by approximately 24%, suggesting that haemodialysis partially removes peginterferon beta-1a from systemic circulation.
Croatian: Jedna hemodijaliza smanjuje koncentraciju peginterferona beta-1a za oko 24%, što ukazuje na to da hemodijaliza djelomično uklanja peginterferon beta-1a iz sistemske cirkulacije.
English: The most common adverse drug reactions (ADR) (at a higher incidence than placebo) for Plegridy 125 micrograms subcutaneously every 2 weeks were injection site erythema, influenza like illness, pyrexia, headache, myalgia, chills, injection site pain, asthenia, injection site pruritus, and arthralgia.
Croatian: Najčešće nuspojave (veća incidencija nego placebo) Plegridyja u dozi od 125 mikrograma supkutanom injekcijom svaka 2 tjedna bile su eritem na mjestu injiciranja, bolest nalik gripi, pireksija, glavobolja, mialgija, zimica, bol na mjestu injiciranja, astenija, pruritus na mjestu injiciranja i artralgija.
English: c. Continue to hold the pen firmly down on your injection site until the clicking sounds have stopped (see Figure H).
Croatian: Nastavite čvrsto držati brizgalicu pritisnutu na mjesto injekcije sve dok ne prestane zvuk otkucavanja (pogledajte sliku H).
English: Subcutaneous peginterferon beta-1a resulted in approximately 4-, 9-, and 13-fold higher exposure (AUC168h) values and approximately 2-, 3.5- and 5-fold higher Cmax, following single doses of 63 (6 MIU), 125 (12 MIU), and 188 (18 MIU) micrograms respectively, compared to intramuscular administration of 30 (6 MIU) micrograms non-pegylated beta-1a.
Croatian: Supkutano injiciranje peginterferona beta-1a rezultiralo je otprilike u 4, 9, i 13 puta višim vrijednostima izloženosti (AUC168h) i u otprilike 2, 3,5 i 5 puta višim Cmax, nakon primjene jednokratne doze od 63 (6 MIU), 125 (12 MIU), odnosno 188 (18 MIU) mikrograma u usporedbi s intramuskularnim primjenom od 30 (6 MIU) mikrograma nepegiliranog interferona beta-1a.