FrancophonIA/ELRC3.0 huggingface dataset:
English: Famvir and associated names (see Annex I) 125 mg film-coated tablets Famvir and associated names (see Annex I) 250 mg film-coated tablets Famvir and associated names (see Annex I) 500 mg film-coated tablets
Slovenian: Famvir in z njim povezana imena (glejte dodatek I) 125 mg filmsko obložene tablete Famvir in z njim povezana imena (glejte dodatek I) 250 mg filmsko obložene tablete Famvir in z njim povezana imena (glejte dodatek I) 500 mg filmsko obložene tablete
English: Famciclovir needs aldehyde oxidase to be converted into penciclovir, its active metabolite.
Slovenian: Za pretvorbo famciklovirja v penciklovir, njegov aktivni metabolit, je potreben encim aldehidoksidaza.
English: Therefore, 125mg bid dose was identified as the lowest effective dose.
Slovenian: Iz tega razloga je bil kot najmanjši učinkoviti odmerek določen odmerek 125 mg dvakrat dnevno.
English: HOW TO TAKE FAMVIR
Slovenian: KAKO JEMATI ZDRAVILO FAMVIR
English: During suppressive treatment with antiviral agents, the frequency of viral shedding is significantly reduced.
Slovenian: Med zdravljenjem s protivirusnim zdravilom za preprečevanje okužbe je pogostnost sproščanja virusov bistveno zmanjšana, vendar je prenos virusov še vedno možen.
English: The famciclovir 500mg tid dose regimen was chosen as representing the highest approved dose for herpes zoster in immunocompetent patients.
Slovenian: Famciklovir v odmerku 500 mg trikrat dnevno je bil izbran kot največji odobreni odmerek za imunokompetentne bolnike s herpesom zoster.
English: The proportion of patients who experienced an ocular manifestation during the study was similar between famciclovir and aciclovir recipients.
Slovenian: Delež bolnikov, ki so imeli v času študije očesni herpes, je bil pri uporabi famciklovirja in aciklovirja podoben.
English: Famvir can cause dizziness, drowsiness or confusion.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Famvir lahko povzroči omotičnost, zaspanost ali zmedenost.
English: In an active-controlled clinical study, famciclovir was shown to be effective in the treatment of ophthalmic zoster in immunocompetent patients.
Slovenian: V aktivno kotrolirani klinični študiji se je pokazalo, da je famciklovir učinkovit pri zdravljenju očesnega herpesa zostra pri bolnikih z normalnim imunskim odzivom.
English: The proportion of patients with severe ocular manifestations was also similar in both treatment groups.
Slovenian: Prav tako je bil v obeh skupinah podoben delež bolnikov z resno obliko očesnega herpesa.
English: − the treatment of first and recurrent episodes of genital herpes in immunocompetent adults
Slovenian: − zdravljenju prve in ponavljajočih se epizod genitalnega herpesa pri imunokompetentnih odraslih bolnikih;
English: Study 024 was a randomised, double-blind, placebo-controlled trial which looked at time to first recurrence.
Slovenian: Študija 024 je bila randomizirana, dvojno slepa raziskava, kontrolirana s placebom, ki je proučevala čas do prve ponovne epizode virusnega obolenja.
English: Therefore, in addition to therapy with famciclovir, it is recommended that patients use safer sex practices.
Slovenian: Iz tega razloga je za bolnike poleg zdravljenja s famciklovirjem priporočena tudi uporaba zaščite pri spolnih odnosih.
English: Two placebo-controlled 12-month studies in immunocompetent patients with recurrent genital herpes showed that famciclovir-treated patients had a significant reduction of recurrences as compared to placebo-treated patients.
Slovenian: V dveh s placebom kontroliranih 12-mesečnih študijah, ki so vključevale bolnike z normalnim imunskim odzivom, pri katerih je prihajalo do ponovitev genitalnega herpesa, se je pokazalo, da je pri bolnikih, ki so prejemali famciklovir, prišlo do bistveno manj ponovitev kot pri bolnikih, ki so prejemali placebo.
English: Famvir and associated names (see Annex I) 125 mg film-coated tablets Famvir and associated names (see Annex I) 250 mg film-coated tablets Famvir and associated names (see Annex I) 500 mg film-coated tablets [See Annex I - To be completed nationally]
Slovenian: Famvir in z njim povezana imena (glejte dodatek I) 125 mg filmsko obložene tablete Famvir in z njim povezana imena (glejte dodatek I) 250 mg filmsko obložene tablete Famvir in z njim povezana imena (glejte dodatek I) 500 mg filmsko obložene tablete [Glejte dodatek I - Izpolni država članica]
English: These were generally mild or moderate in nature and occurred at a similar incidence in patients receiving placebo treatment.
Slovenian: V kliničnih študijah so poročali o glavobolu in navzei, ki sta bila večinoma blaga ali zmerna in sta se pojavljala približno enako pogosto pri bolnikih, ki so prejemali placebo.
English: The extent of systemic availability (AUC) of penciclovir from oral famciclovir is unaffected by food.
Slovenian: Hrana ni vplivala na obseg sistemske uporabnosti (AUC) penciklovirja po peroralnem vnosu famciklovirja.
English: However, it was noted that the proportion of placebo recipients with shedding from anogenital sites in Period 1 was approximately 4 times greater than that of famciclovir-treated patients with anogenital shedding, and differences between treatment groups in proportions of patients with shedding were statistically significant in both Period 1 and cross-over analyses.
Slovenian: Kljub temu je bilo ugotovljeno, da je bil med bolniki, ki so prejemali placebo, delež bolnikov, pri katerih se je virus izločal iz anogenitalnih predelov, v prvem obdobju zdravljenja približno štirikrat večji od deleža pri bolnikih, zdravljenih s famciklovirjem.
English: An analysis of current data on viral resistance to famciclovir was reviewed and reflected in this section.
Slovenian: Poglavje vključuje revizijo analize aktualnih podatkov o odpornosti virusa na famciklovir in njene izsledke.
English: The viral DNA polymerase mistakenly incorporates the nucleoside analogue, penciclovir triphosphate, into the growing viral DNA strand instead of dGTP, which results in termination of the viral DNA chain and halting of viral replication.
Slovenian: Virusna DNK-polimeraza v rastočo vijačnico virusne DNK namesto deoksigvanozin trifosfata po pomoti vgradi nukleozidni analog penciklovir trifosfat, zato se veriga virusne DNK prekine in replikacija virusa ustavi.
English: The approved daily dose regimen for either episodic or suppressive therapy of recurrent genital herpes in HIV-infected patients is 500mg bid.
Slovenian: Odobreni dnevni odmerek za zdravljenje epizod in supresivno zdralvjenje ponavljajočega se genitalnega herpesa pri bolnikih, okuženih s HIV, je 500 mg dvakrat dnevno.
English: Urticaria, serious skin reactions* (e.g. erythema multiforme, StevensJohnson Syndrome, Toxic Epidermal Necrolysis).
Slovenian: urtikarija, resne kožne reakcije* (na primer multiformni eritem, Stevens-Johnsonov sindrom, toksična epidermalna nekroliza) * neželeni učinki, ki jih v kliničnih študijah niso opažali, pogostnost temelji na "pravilu trojke"
English: Overall, there were no differences in the nature, frequency or severity of adverse events among the three active dose groups or placebo.
Slovenian: Na splošno ni bilo med navedenimi tremi skupinami, ki so prejemale različne odmerke učinkovine, in skupino s placebom nobenih razlik v naravi, pogostosti in resnosti neželenih učinkov.
English: Patients who met eligibility criteria were randomly assigned to receive either famciclovir (125mg tid, 250mg bid, or 250mg tid.)
Slovenian: Bolnikom, ki so izpolnjevali ustrezna merila, so naključno predpisali prejemanje famciklovirja (125 mg trikrat na dan, 250 mg dvakrat na dan ali 250 mg trikrat na dan) ali placeba 52 tednov.
English: Clinical response should be closely monitored, particularly in immunocompromised patients.
Slovenian: Zlasti pri bolnikih z oslabljenim imunskim odzivom je treba skrbno spremljati klinični odziv.
English: On this endpoint the 250mg bid dose was superior to the 125mg bid dose.
Slovenian: Ob upoštevanju tega pokazatelja je bil odmerek 250 mg superioren glede na odmerek 125 mg.
English: In placebo-controlled and active-controlled studies both in immunocompetent and immunocompromised patients with uncomplicated herpes zoster, famciclovir was effective in the resolution of lesions.
Slovenian: V študijah, kontroliranih s placebom, in v aktivno kontroliranih študijah, ki so vključevale tako bolnike z normalnim kot tiste z oslabljenim imunskim odzivom, ki so imeli nezapleten herpes zoster, je famciklovir učinkovito zdravil spremembe na koži in sluznicah.
English: Based on available data, the CHMP considered that the 500mg tid regimen appeared to be more efficacious than the 250mg tid regimen, with respect to the investigated endpoints.
Slovenian: Na podlagi razpoložljivih podatkov je CHMP menil, da je glede na proučene pokazatelje režim zdravljenja z odmerkom 500 mg trikrat dnevno učinkovitejši od režima z odmerkom 250 mg trikrat dnevno.
English: Immunocompetent patients with uncomplicated herpes zoster were enrolled in both studies.
Slovenian: V študiji so bili vključeni imunokompetentni bolniki z nezapletenim herpesom zoster.
English: SUPPRESSION OF RECURRENT HERPES
Slovenian: SUPRESIJA PONAVLJAJOČEGA SE HERPESA
English: The terminal plasma half-life of penciclovir in patients with herpes zoster was 2.8 h and 2.7 h, respectively, after single and repeated dosing of famciclovir.
Slovenian: Končni razpolovni čas izločanja penciklovirja iz plazme je bil 2,8 ure po enkratnem odmerku famciklovirja in 2,7 ure po večkratnem odmerjanju famciklovirja.
English: − the treatment of herpes zoster and ophthalmic zoster in immunocompetent adults (see section
Slovenian: − zdravljenju herpesa zoster in oftalmičnega herpesa zoster pri imunokompetentnih odraslih bolnikih (glejte poglavje 4.4);
English: Section 4.2: Posology and Method of Administration
Slovenian: Poglavje 4.2: Odmerjanje in način uporabe
English: There were no differences in efficacy noted among the three active dose groups.
Slovenian: Med skupinami, ki so prejemale navedene odmerke učinkovine, niso ugotovili nobenih razlik v učinkovitosti.
English: HERPES ZOSTER HERPES ZOSTER IN IMMUNOCOMPETENT ADULTS
Slovenian: HERPES ZOSTER HERPES ZOSTER PRI IMUNOKOMPETENTNIH ODRASLIH BOLNIKIH
English: In the two pivotal studies three regimen were investigated: 125mg tid, 250mg bid, 250mg tid.
Slovenian: V dveh osrednjih študijah so proučevali naslednje tri režime: 125 mg trikrat dnevno, 250 mg dvakrat dnevno in 250 mg trikrat dnevno.
English: All three doses were significantly superior to placebo in the time to healing of lesions, loss of symptoms and the time to cessation of viral shedding.
Slovenian: Vsi trije odmerki so se glede na čas do zaceljenja lezij, izginotje simptomov in čas do prenehanje izločanja virusa izkazali kot pomembno superiorni v primerjavi s placebom.
English: What Famvir contains
Slovenian: Kaj vsebuje zdravilo Famvir
English: The primary efficacy endpoint in both studies was time to full crusting of lesions in the primary affected dermatomal region in the intent-to-treat (ITT) population.
Slovenian: HIV: virus človeške imunske pomanjkljivosti študijah je bil čas do popolnega nastanka krast na lezijah prvotno prizadetega predela dermatoma pri populaciji, določeni za zdravljenje.
English: The recommended dose for treating HIV-infected patients is larger than that recommended for immunocompetent patients as clinical experience and prescribing practice suggested that higher doses of antivirals are required to provide adequate suppression in HIV-infected patients.
Slovenian: potrebni večji odmerki protivirusnih zdravil, je priporočeni odmerek za zdravljenje bolnikov, okuženih s HIV, večji od odmerka, ki se priporoča za imunokompetentne bolnike.
English: Impaired fertility (including histopathological changes in the testis, altered sperm morphology, reduced sperm concentration and motility, and reduced fertility) was observed in male rats given 500 mg/kg/day.
Slovenian: Pri podganjih samcih, ki so jim dajali odmerek 500 mg/kg/dan, so opažali zmanjšano plodnost (vključno s histopatološkimi spremembami v testisih, spremembami morfologije spermijev, z znižanima koncentracijo in gibljivostjo spermijev ter z zmanjšano plodnostjo).
English: Most of the analyses performed showed that only famciclovir 250mg bid gave significantly better results than placebo.
Slovenian: Večina analiz je pokazala, da so bili v primerjavi s placebom rezultati znatno boljši le pri uporabi famciklovirja v odmerku 250 mg dvakrat dnevno.
English: Study 008 demonstrated statistically significant differences of famciclovir 750mg tid (ter in die, three times a day) as compared to placebo with respect to the primary as well as several secondary endpoints.
Slovenian: Študija 008 je glede na primarni in več sekundarnih pokazateljev pokazala statistično značilne razlike pri uporabi famciklovirja v odmerku 750 mg trikrat dnevno v primerjavi s placebom.
English: Consideration should be given to intravenous antiviral therapy when response to oral therapy is considered insufficient.
Slovenian: Če se odziv na peroralno zdravljenje ne zdi zadosten, je treba razmisliti o uporabi intravenskih protivirusnih zdravil.
English: Recurrent genital herpes in immunocompromised adults Episodic treatment of recurrent genital herpes: 500 mg twice daily for seven days.
Slovenian: Ponovitev genitalnega herpesa pri odraslih z oslabljenim imunskim odzivom Občasno zdravljenje ponovnih izbruhov genitalnega herpesa: 500 mg dvakrat na dan sedem dni.
English: The terminal plasma half-life of penciclovir after both single and repeat dosing with famciclovir was approximately 2 hours.
Slovenian: Končni razpolovni čas izločanja penciklovirja iz plazme je približno 2 uri tako po enkratnem kot po večkratnem odmerjanju famciklovirja.
English: If you have a normal immune system, the recommended dose is - one tablet of 500 mg, three times a day, for seven days
Slovenian: Če vaš imunski sistem deluje normalno, je priporočeni odmerek: - ena tableta 500 mg trikrat na dan sedem dni
English: PHARMACEUTICAL PARTICULARS 6.1 List of excipients [To be completed nationally] 6.2 Incompatibilities [To be completed nationally] 6.3 Shelf life [To be completed nationally] 6.4 Special precautions for storage [To be completed nationally] 6.5 Nature and contents of container [To be completed nationally] 6.6 Special precautions for disposal
Slovenian: FARMACEVTSKI PODATKI 6.1 Seznam pomožnih snovi [Izpolni država članica] 6.2 Inkompatibilnosti [Izpolni država članica]
English: − the treatment of recurrent episodes of genital herpes in immunocompromised adults
Slovenian: − zdravljenju ponavljajočih se epizod genitalnega herpesa pri imunokompromitiranih odraslih bolnikih;
English: If you have a reduced immune system, the recommended dose is - one tablet of 500 mg three times a day, for ten days.
Slovenian: Če je vaš imunski sistem oslabljen, je priporočeni odmerek: - ena tableta 500 mg trikrat na dan deset dni.
English: The CHMP agreed that the indication treatment of ophthalmic zoster in immunocompetent patients was supported by the available data.
Slovenian: CHMP se je strinjal, da razpoložljivi podatki podpirajo indikacijo za zdravljenje oftalmičnega herpesa zoster pri imunokompetentnih bolnikih.
English: However, the CHMP endorsed the MAH's proposal to commit to specifically monitor and report malignancies within future PSURs.
Slovenian: CHMP odgovora imetnika dovoljenja za promet z zdravilom ni štel za docela zadovoljivega, vendar pa je potrdil njegov predlog, da bo posebej spremljal pojav malignih obolenj in poročal o njih v prihodnjih redno posodobljenih varnostnih poročilih.
English: There was no effect on the incidence of neoplasia in male rats or in mice of either sex.
Slovenian: Pri podganjih samcih oziroma pri miših obeh spolov ni bilo vpliva na pogostnost neoplazij.
English: For the first outbreak, the recommended dose is: - one tablet of 250 mg three times a day, for five days.
Slovenian: Pri prvem izbruhu je priporočeni odmerek: - ena tableta 250 mg trikrat na dan pet dni.
English: The CHMP endorsed the 500mg tid dose during a period of 7 days for this indication.
Slovenian: CHMP je za navedeno indikacijo potrdil odmerek 500 mg trikrat dnevno v obdobju 7 dni.
English: HERPES ZOSTER IN IMMUNOCOMPETENT AND IMMUNOCOMPROMISED ADULTS
Slovenian: HERPES ZOSTER PRI IMUNOKOMPETENTNIH IN IMUNOKOMPROMITIRANIH ODRASLIH BOLNIKIH
English: 250 mg three times daily for 5 days
Slovenian: 250 mg trikrat na dan 5 dni
English: 125 mg twice daily for 5 days 125 mg once daily for 5 days Haemodialysis patients 125 mg following each dialysis during 5 days
Slovenian: 125 mg dvakrat na dan 5 dni 125 mg enkrat na dan 5 dni bolniki, ki se zdravijo s hemodializo
English: To treat further outbreaks, the recommended dose is: - one tablet of 125 mg twice a day, for five days.
Slovenian: Za zdravljenje ponovnih izbruhov, je priporočeni odmerek: - ena tableta 125 mg dvakrat na dan pet dni.
English: Commitments to be undertaken by the MAH were agreed.
Slovenian: Dosežen je bil sporazum o obveznostih, ki so bile naložene imetniku dovoljenja za promet z zdravilom.
English: To treat the current outbreak, the recommended dose is: - one tablet of 500 mg twice a day, for seven days.
Slovenian: Za zdravljenje že prisotnega izbruha je priporočeni odmerek: - ena tableta 500 mg dvakrat na dan sedem dni.
English: Genital herpes in immunocompetent adults - first episode of genital herpes 250 mg three times daily for 5 days ≥ 40
Slovenian: Genitalni herpes pri odraslih z normalnim imunskim odzivomprvi pojav genitalnega herpesa 250 mg trikrat na dan 5 dni
English: You should not have sex if you have genital sores or blisters.
Slovenian: Kadar imate na spolovilih razjede ali mehurčke, ne smete imeti spolnih odnosov.
English: HERPES ZOSTER IN IMMUNOCOMPROMISED ADULTS
Slovenian: HERPES ZOSTER PRI IMUNOKOMPROMITIRANIH ODRASLIH BOLNIKIH
English: Study 008 was a randomised, double-blind, placebo-controlled study.
Slovenian: Študija 008 je bila randomizirana, dvojno slepa in kontrolirana s placebom.
English: To prevent future outbreaks, the recommended dose is: - one tablet of 250 mg twice a day.
Slovenian: Za preprečevanje ponovnih izbruhov je priporočeni odmerek: - ena tableta 250 mg dvakrat na dan.
English: Dose adjustment is necessary in patients with renal impairment (see section 4.2).
Slovenian: Pri bolnikih z okvaro ledvic je treba odmerjanje prilagoditi (glejte poglavje 4.2).
English: No dose adjustment based on age is recommended unless renal function is impaired.
Slovenian: Razen v primeru oslabljene ledvične funkcije se prilagoditev odmerka glede na starost ne priporoča.
English: The pharmacokinetics of penciclovir have not been evaluated in patients with severe hepatic impairment.
Slovenian: Pri bolnikih s hudo okvaro jeter farmakokinetičnih lastnosti penciklovirja niso ocenjevali.
English: Studies 035 and 036 were randomised, double-blind, placebo-controlled multicentre trials designed to compare the efficacy and safety of 3 doses of famciclovir (125mg, 250mg, 500mg) with that of placebo for acute treatment of a recurrent episode of genital herpes.
Slovenian: Njun namen je bil primerjati učinkovitost in varnost 3 odmerkov famciklovirja (125 mg, 250 mg, 500 mg) z učinkovitostjo in varnostjo placeba pri akutnem zdravljenju ponovne epizode genitalnega herpesa.
English: The dose regimen for suppression of recurrent genital herpes in immunocompetent patients was addressed in three studies too.
Slovenian: Navedene tri študije so obravnavale tudi režim odmerjanja za supresijo ponavljajočega se genitalnega herpesa pri imunokompetentnih bolnikih.
English: Suppressive therapy should be discontinued after a maximum of 12 months of continuous antiviral therapy to reassess recurrence frequency and severity.
Slovenian: Preprečevanje ponovitev genitalnega herpesa pri odraslih z normalnim imunskim odzivom 250 mg dvakrat na dan. Supresivno zdravljenje je treba prekiniti po največ 12 mesecih neprekinjene uporabe protivirusnega zdravila, da bi lahko ponovno ocenili pogostnost in izraženost ponovitev.
English: No dose adjustment is recommended for patients with mild and moderate hepatic impairment (see sections 4.2 and 4.4).
Slovenian: Pri bolnikih z blago ali zmerno okvaro jeter odmerjanja ni treba prilagajati (glejte poglavji 4.2 in 4.4).
English: Moreover, immunocompromised patients with ophthalmic zoster or those with a high risk for disease dissemination and visceral organ involvement should be treated with intravenous antiviral therapy.
Slovenian: Poleg navedenih bolnikov je treba z intravenskimi protivirusnimi zdravili zdraviti tudi bolnike z oslabljenim imunskim odzivom, ki imajo očesni herpes zoster, in bolnike s povečanim tveganjem za razsoj bolezni ali razširitev na visceralne organe.
English: Dose recommendations for adult patients with renal impairment are provided in Table 1.
Slovenian: V preglednici 1 so prikazana priporočila za odmerjanje pri odraslih bolnikih z okvaro ledvic.
English: Famciclovir is the oral prodrug of penciclovir.
Slovenian: Famciklovir je peroralno predzdravilo penciklovirja.
English: 500 mg twice daily for 10 days
Slovenian: 500 mg dvakrat na dan 10 dni
English: Haemodialysis patients 250 mg following each dialysis
Slovenian: 250 mg po vsaki dializi
English: Several indications were identified for Famvir in the SPCs of different MSs.
Slovenian: Povzetki glavnih značilnosti zdravila Famvir so v različnih državah članicah EU vključevali številne indikacije.
English: Clinical studies have not been conducted in HSV-infected patients immunocompromised for other causes than HIV-infection (see section 5.1).
Slovenian: Pri bolnikih, ki so imeli okužbo z virusom herpes simpleks in oslabljen imunski odziv brez povezave z okužbo z virusom HIV, niso izvajali kliničnih študij (glejte poglavje 5.1).
English: 500 mg twice daily for 7 days
Slovenian: 500 mg dvakrat na dan 7 dni
English: Contact a doctor or go to the emergency department at your nearest hospital straight away if you get any of these effects.
Slovenian: Če pride do katerega od zgoraj navedenih neželenih učinkov, takoj povejte zdravniku ali pojdite do urgentne enote najbližje bolnišnice.
English: Haemodialysis patients 125 mg following each dialysis
Slovenian: 125 mg po vsaki dializi
English: Package leaflet The package leaflet was updated to reflect the SPC harmonisation.
Slovenian: Navodilo za uporabo je bilo posodobljeno tako, da odraža uskladitev povzetka glavnih značilnosti zdravila.
English: Suppression of recurrent genital herpes in immunocompetent adults 250 mg twice daily.
Slovenian: Preprečevanje ponovitev genitalnega herpesa pri odraslih z normalnim imunskim odzivom250 mg dvakrat na dan
English: The most potent inhibitor identified in these in vitro studies was raloxifene.
Slovenian: V okviru teh in vitro študij je bilo ugotovljeno, da je najmočnejši zaviralec raloksifen.
English: Famciclovir was not found to be genotoxic in a comprehensive battery of in vivo and in vitro tests designed to detect gene mutation, chromosomal damage and repairable damage to DNA.
Slovenian: V obsežni kombinaciji in vivo in in vitro testov, namenjenih odkrivanju genskih mutacij, kromosomskih poškodb in popravljivih poškodb DNA, so ugotovili, da famciklovir ni genotoksičen.
English: 500 mg three times daily for 7 days
Slovenian: 500 mg trikrat na dan 7 dni
English: SUPPRESSION OF RECURRENT GENITAL HERPES IN IMMUNOCOMPETENT AND IMMUNOCOMPROMISED ADULTS
Slovenian: SUPRESIJA PONAVLJAJOČEGA SE GENITALNEGA HERPESA PRI IMUNOKOMPETENTNIH IN IMUNOKOMPROMITIRANIH ODRASLIH BOLNIKIH
English: 500 mg once daily for 7 days 250 mg once daily for 7 days Haemodialysis patients 250 mg following each dialysis during 7 days
Slovenian: 500 mg enkrat na dan 7 dni 250 mg enkrat na dan 7 dni bolniki, ki se zdravijo s hemodializo
English: Concurrent use of probenecid may result in increased plasma concentrations of penciclovir, the active metabolite of famciclovir, by competing for elimination.
Slovenian: Penciklovir je aktivni metabolit famciklovirja in s probenecidom tekmuje pri procesu eliminacije.
English: 500 mg three times daily for 10 days
Slovenian: 500 mg trikrat na dan 10 dni
English: 250 mg twice daily for 5 days 250 mg once daily for 5 days Haemodialysis patients 250 mg following each dialysis during 5 days
Slovenian: 250 mg dvakrat na dan 5 dni 250 mg enkrat na dan 5 dni bolniki, ki se zdravijo s hemodializo