FrancophonIA/ELRC3.0 huggingface dataset:
English: CBR=clinical benefit response; CI=confidence interval; N=number of patients; OR=objective response.
Danish: CBR = positiv klinisk respons (clinical benefit response), CI = konfidensinterval, N = antal patienter, OR = objektiv respons.
English: Effect of CYP3A inducers
Danish: Virkning af CYP3A-induktorer
English: • Clarithromycin and telithromycin antibiotics used to treat bacterial infections.
Danish: • Clarithromycin og telithromycin, der er antibiotika, som anvendes til behandling af bakterielle infektioner.
English: Palbociclib was not mutagenic in a bacterial reverse mutation (Ames) assay and did not induce structural chromosomal aberrations in the in vitro human lymphocyte chromosome aberration assay.
Danish: Palbociclib var ikke mutagen i en bakteriel tilbagemutationtest (Ames) og inducerede ikke strukturelle kromosomafvigelser i den humane in vitro lymfocyt kromosomafvigelsestest.
English: In addition, cardiovascular effects (QTc prolongation, decreased heart rate, and increased RR interval and systolic blood pressure) were identified in telemetered dogs at ≥4 times human clinical exposure based on Cmax.
Danish: Der blev derudover identificeret kardiovaskulære virkninger (QTc-forlængelse, nedsat hjertefrekvens og forlænegt RR-interval og forhøjet systolisk blodtryk) ved telemetri hos hunde ved ≥ 4 gange den kliniske eksponering baseret på Cmax.
English: Primary Analysis (26 February 2016 Cutoff)
Danish: Primær analyse (26. februar 2016 som skæringsdato)
English: In vitro, the uptake of palbociclib into human hepatocytes occurred mainly via passive diffusion.
Danish: In vitro optages palbociclib primært i humane hepatocytter via passiv diffusion.
English: In vitro and in vivo studies indicate that palbociclib undergoes extensive hepatic metabolism in humans.
Danish: In vitro- og in vivo-studier tyder på, at palbociclib gennemgår en omfattende hepatisk metabolisme hos mennesker.
English: Based on in vitro data, palbociclib is predicted to inhibit intestinal P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) mediated transport.
Danish: Baseret på in vitro-data forventes palbociclib at hæmme transportmedieret intestinal P-glykoprotein (P-gp) og brystkræft resistent protein (BCRP).
English: The overall safety profile of IBRANCE is based on pooled data from 872 patients who received palbociclib in combination with endocrine therapy (N=527 in combination with letrozole and N=345 in combination with fulvestrant) in randomised clinical studies in HR-positive, HER2-negative advanced or metastatic breast cancer.
Danish: IBRANCEs samlede sikkerhedsprofil er baseret på puljede data fra 872 patienter, som fik palbociclib i kombination med endokrinterapi (N = 527 i kombination med letrozol og N = 345 i kombination med fulvestrant) i randomiserede kliniske studier hos patienter med HR-positiv, HER2-negativ fremskreden eller metastatisk brystkræft.
English: What you need to know before you take IBRANCE 3.
Danish: Det skal du vide, før du begynder at tage IBRANCE 3.
English: 125 mg/day
Danish: 125 mg/dag
English: The recommended dose is 125 mg of palbociclib once daily for 21 consecutive days followed by 7 days off treatment (Schedule 3/1) to comprise a complete cycle of 28 days.
Danish: Den anbefalede dosis er 125 mg palbociclib en gang dagligt i 21 konsekutive dage efterfulgt af 7 dage uden behandling (doseringsplan 3/1), så et komplet cyklusforløb består af 28 dage.
English: • Pravastatin and rosuvastatin used to treat high cholesterol levels.
Danish: • Pravastatin og rosuvastatin, som anvendes til behandling af højt kolesteroltal.
English: Thus, men may consider sperm preservation prior to beginning therapy with IBRANCE.
Danish: Mænd bør derfor overveje sæddeponering før start af behandling med IBRANCE.
English: In vitro evaluations indicate that palbociclib has low potential to inhibit the activities of organic anion transporter (OAT)1, OAT3, organic cation transporter (OCT)2, organic anion transporting polypeptide (OATP)1B1, OATP1B3, and bile salt export pump (BSEP) at clinically relevant concentrations.
Danish: In vitro-evalueringer tyder på, at palbociclib har lille potentiale for at hæmne organisk aniontransporter (OAT)1, OAT3, organisk kationtransporter (OCT)2, organisk anion-transportpolypeptid (OATP)1B1, OATP1B3 og galdesalteksportpumpe (BSEP) ved klinisk relevante koncentrationer.
English: • Alfentanil used for anaesthesia in surgery; fentanyl used in pre-procedures as a pain reliever as well as an anaesthetic.
Danish: • Alfentanil, som anvendes til bedøvelse ved operation, og fentanyl, som anvendes inden indgreb som et smertestillende middel samt til bedøvelse.
English: • Colchicine used to treat gout.
Danish: • Colchicin, som anvendes til behandling af gigt.
English: Therefore, concomitant use of palbociclib with strong CYP3A4 inducers should be avoided.
Danish: Samtidig brug af palbociclib og potente CYP3A4-induktorer skal derfor undgås.
English: At the time of the updated analyses, the median time from randomisation to second subsequent therapy was 38.8 months in the palbociclib + letrozole arm and 28.8 months in the placebo + letrozole arm, HR 0.73 (95% CI: 0.58, 0.91).
Danish: På tidspunktet for de opdaterede analyser var median tiden fra randomisering til den anden efterfølgende kræftbehandling 38 måneder i palbociclib + letrozol armen og 28,8 måneder i placebo + letrozol armen, HR 0,73 (95% CI: 0,58-0,91).
English: Palbociclib is a highly selective, reversible inhibitor of cyclin-dependent kinases (CDK) 4 and 6.
Danish: Palbociclib er en yderst selektiv, reversibel hæmmer af cyclinafhængig kinase (CDK) 4 og 6.
English: The majority of the material was excreted as metabolites.
Danish: Størstedelen af palbociclib blev udskilt som metabolitter.
English: If you forget to take IBRANCE
Danish: Hvis du har glemt at tage IBRANCE
English: Overall, neutropenia of any grade was reported in 716 (82.1%) patients receiving IBRANCE regardless of the combination, with Grade 3 neutropenia being reported in 500 (57.3%) patients, and Grade 4 neutropenia being reported in 97 (11.1 %) patients (see Table 4).
Danish: Neutropeni af enhver grad blev rapporteret hos 716 (82,1 %) patienter, som fik IBRANCE, uanset kombinationen; neutropeni grad 3 blev rapporteret hos 500 (57,3 %) patienter og neutropeni grad 4 hos 97 (11,1 %) patienter (se skema 4).
English: When the strong inhibitor is discontinued, increase the IBRANCE dose (after 3-5 half-lives of the inhibitor) to the dose used prior to the initiation of the strong CYP3A inhibitor (see section 4.5).
Danish: Når den potente hæmmer seponeres, skal dosis af IBRANCE øges (efter 3-5 gange hæmmerens halveringstid) til den dosis, der blev anvendt inden behandling med den potente CYP3Ahæmmer (se pkt.
English: The relevance of the male rat neoplastic finding to humans is unknown.
Danish: Relevansen af disse neoplastiske fund hos hanrotterne er ukendt for mennesker.
English: Women of childbearing potential who are receiving this medicinal product, or their male partners should use adequate contraceptive methods (e.g., double-barrier contraception such as condom and diaphragm).
Danish: Kvinder i den fødedygtige alder, som får dette lægemiddel, eller deres mandlige partnere skal bruge sikker prævention (f.eks. dobbelt prævention med dobbelt barriere som kondom og pessar).
English: The median age of patients enrolled in this study was 62 years (range 28-89), 48.3% of patients had received chemotherapy and 56.3% had received antihormonal therapy in the (neo)adjuvant setting prior to their diagnosis of advanced breast cancer while 37.2% of patients had received no prior systemic therapy in the (neo)adjuvant setting.
Danish: Gennemsnitsalderen for patienter tilmeldt dette studie var 62 år (28-89 år), 48,3 % af patienterne havde fået kemoterapi, og 56,3 % havde fået antihormonbehandling som (neo)-adjuverende behandling forud for diagnosen ”fremskreden brystkræft”, mens 37,2 % af patienterne ikke havde fået forudgående systemisk neoadjuverende behandling.
English: If coadministration with a strong CYP3A inhibitor is unavoidable, reduce the IBRANCE dose to 75 mg once daily.
Danish: Hvis samtidig administration med en potent CYP3A4-hæmmer ikke kan undgås, skal dosis af IBRANCE reduceres til 75 mg en gang dagligt.
English: Based on a population pharmacokinetic analysis in 183 patients with cancer (50 male and 133 female patients, age ranging from 22 to 89 years, and body weight ranging from 38 to 123 kg), gender had no effect on the exposure of palbociclib, and age and body weight had no clinically important effect on the exposure of palbociclib.
Danish: Baseret på en populationsfarmakokinetisk analyse af 183 patienter med kræft (50 mandlige og 133 kvindelige patienter i en alder fra 22 til 89 år, og en kropsvægt fra 38 til 123 kg) har køn ingen indvirkning på eksponeringen for palbociclib, og alder og kropsvægt har ingen klinisk signifikant indvirkning på eksponeringen for palbociclib.
English: Palbociclib was assessed for carcinogenicity in a 6-month transgenic mouse study and in a 2-year rat study.
Danish: Palbociclibs karcinogene potentiale blev vurderet i et seks måneders forsøg med transgene mus og i et toårigt forsøg med rotter.
English: • fever, chills, weakness, shortness of breath, bleeding, or easy bruising which could be a sign of a serious blood disorder.
Danish: • Feber, kulderystelser, svækkelse, kortåndethed, blødning eller øget tendens til at få blå mærker, da det kan være et tegn på en alvorlig blodsygdom.
English: When coadministered with palbociclib, the recommended dose of fulvestrant is 500 mg administered intramuscularly on Days 1, 15, 29, and once monthly thereafter.
Danish: Ved samtidig administration af palbociclib er den anbefalede dosis af fulvestrant 500 mg intramuskulært på dag 1, 15, 29 og derefter én gang om måneden.
English: Palbociclib-related findings in the testis, epididymis, prostate, and seminal vesicle included decreased organ weight, atrophy or degeneration, hypospermia, intratubular cellular debris, lower sperm motility and density, and decreased secretion.
Danish: Palbociclib-relaterede fund i testes, epididymis, prostata og sædblære omfattede nedsat organvægt, atrofi eller degeneration, hypospermi, intratubulært celleaffald, lavere spermmotilitet og -tæthed og nedsat sekretion.
English: Effects on glucose metabolism were associated with findings in the pancreas and secondary effects on eye, teeth, kidney, and adipose tissue in studies ≥15 weeks duration in rats only and bone changes were observed in rats only following 27 weeks of dosing.
Danish: Virkning på glucosemetabolismen forbundet med fund i bugspytkirtlen og sekundære virkninger på øjne, tænder, nyrer og fedtvæv blev kun set hos rotter i studier af ≥ 15 ugers varighed, og knogleændringer blev kun observeret hos rotter efter 27 ugers dosering.
English: No dose adjustment of IBRANCE is necessary in patients ≥65 years of age (see section 5.2).
Danish: Ældre Dosisjustering af IBRANCE er ikke nødvendig hos ældre ≥ 65 år (se pkt.
English: OR [% (95% CI)] TTR, Median [months (range)]
Danish: OR [% 95 % CI] TTR, median [måneder (interval)]
English: Partial reversibility of male reproductive organ effects was observed in the rat and dog following a 4- and 12-week nondosing period, respectively.
Danish: Delvis reversibilitet af virkninger på hanlige forplantningsorganer blev observeret hos hanrotter og hanhunde efter en henholdsvis 4 og 12 uger uden dosering.
English: Management of some adverse reactions may require temporary dose interruptions/delays, and/or dose reductions, or permanent discontinuation as per dose reduction schedules provided in Tables 1, 2, and 3 (see sections 4.4 and 4.8).
Danish: Håndtering af visse bivirkninger kan kræve midlertidig seponering/udsættelse af behandlingen og/eller dosisnedsættelse eller permanent seponering i henhold til de anbefalinger for dosisnedsættelse, som er angivet i skema 1, 2 og 3 (se pkt.
English: OR (measurable disease) [% (95% CI)] CBR [% (95% CI)]
Danish: OR (målbar sygdom) % (95 % CI) CBR % (95 % CI)
English: In vivo, palbociclib is a weak, time-dependent inhibitor of CYP3A.
Danish: In vivo er palbociclib en svag tidsafhængig CYP3A-hæmmer.
English: Palbociclib works by blocking proteins called cyclin-dependent kinase 4 and 6, which regulate cell growth and division.
Danish: Palbociclib virker ved at blokere proteiner kaldet cyclinafhængig kinase 4 og 6, som regulerer cellevækst og celledeling.
English: No dose adjustment of IBRANCE is required for patients with mild or moderate hepatic impairment (Child-Pugh classes A and B).
Danish: Dosisjustering af IBRANCE er ikke nødvendig hos patienter med let eller moderat nedsat leverfunktion (Child-Pugh-klasse A og B).
English: Palbociclib in combination with fulvestrant in pre/perimenopausal women has only been studied in combination with an LHRH agonist.
Danish: Palbociclib i kombination med fulvestrant hos præ-/perimenopausale kvinder er kun blevet undersøgt i kombination med en LHRH-agonist.
English: Other medicines and IBRANCE
Danish: Brug af anden medicin sammen med IBRANCE
English: Efficacy results in patients with visceral or non-visceral disease from PALOMA-2 study (intent-to-treat population; 31-May-2017 cutoff date) Visceral Disease
Danish: Effektresultater hos patienter med visceral eller ikke-visceral sygdom fra PALOMA-2 studiet (intent-to-treat population, 31. maj 2017 som skæringsdato) Visceral sygdom ikke-visceral sygdom
English: The capsule length is 21.7 ± 0.3 mm.
Danish: Kapslens længde er 21,7 ± 0,3 mm.
English: Updated Analysis (31 May 2017 Cutoff)
Danish: Opdateret analyse (31. maj 2017 som skæringsdato)
English: When coadministered with palbociclib, the aromatase inhibitor should be administered according to the dose schedule reported in the Summary of Product Characteristics.
Danish: Ved samtidig administration af palbociclib skal aromatasehæmmeren administreres i henhold til dosisplanen angivet i produktresuméet.
English: ALT=alanine aminotransferase; AST=aspartate aminotransferase; ILD=interstitial lung disease; N/n=number of patients; N/A=not applicable.
Danish: ALAT = alanine aminotransferase; ASAT = aspartate aminotransferase; ILS = interstitiel lungesygdom; N/n = antal patienter.
English: • Dihydroergotamine and ergotamine used to treat migraine.
Danish: • Dihydroergotamin og ergotamin, som anvendes til behandling af migræne.
English: • difficulty breathing, dry cough or chest pain which could be a sign of inflammation of the lungs.
Danish: • Åndenød, tør hoste eller brystsmerter kan være tegn på lungebetændelse.
English: Critical visceral disease
Danish: Kritisk alvorlig sygdom
English: For the 51 patients IHC negative for Rb expression, the difference between treatment arms was not statistically significant (HR of 0.868 [95% CI: 0.424, 1.777], mPFS 23.2 versus 18.5 months) for the palbociclib plus letrozole arm versus the placebo plus letrozole arm, respectively.
Danish: Hos de 51 IHC Rb-ekspression negative patienter, var forskellen mellem behandlingsarmene ikke statistisk signifikant (HR 0.868 [95% CI: 0.424; 1.777], mPFS 23.2 versus 18.5 måneder) henholdsvis i palbociclib plus letrozole armen versus placebo plus letrozole armen.
English: Microcrystalline cellulose Lactose monohydrate Sodium starch glycolate type A Colloidal anhydrous silica Magnesium stearate
Danish: Mikrokrystallinsk cellulose Lactosemonohydrat Natriumstivelsesglykolat type A Vandfri kolloid silica Magnesiumstearat
English: In a pharmacokinetic study in healthy volunteers, palbociclib AUCinf and Cmax values were 30% and 35% higher, respectively, in Japanese subjects compared with non-Asian subjects after a single oral dose.
Danish: I et farmakokinetisk studie med raske forsøgspersoner, var værdier for AUCinf og Cmax af palbociclib henholdsvis 30 % og 35 % højere hos japanske forsøgspersoner sammenlignet med ikke-asiatiske forsøgspersoner efter en oral enkeltdosis.
English: Pregnancy and breast-feeding and fertility
Danish: Graviditet, amning og frugtbarhed
English: The primary target organ findings of potential relevance to humans included haematolymphopoietic and male reproductive organ effects in rats and dogs in studies up to 39 weeks duration.
Danish: Fund vedrørende det primære målorgan med potentiel relevans for mennesker omfattede virkninger på det blod-lymfesystemet og hanlige forplantningsorganer hos rotter og hunde i studier af op til 39 ugers varighed.
English: Given the reduced effect on gastric pH of H2-receptor antagonists and local antacids compared to PPIs, no clinically relevant effect of H2-receptor antagonists or local antacids on palbociclib exposure is expected when palbociclib is taken with food.
Danish: I betragtning af den reducerede virkning på ventriklens pH-værdi, som H2-receptorantagonister og lokalt virkende syreneutraliserende stoffer har sammenlignet med PPI'er, forventes det ikke, at H2-receptorantagonister eller lokalt virkende syreneutraliserende stoffer har nogen klinisk relevant indvirkning på eksponering for palbociclib, når palbociclib indtages med mad.
English: c Neutropenia includes the following PTs: Neutropenia, Neutrophil count decreased.
Danish: c. Neutropeni omfatter følgende foretrukne termer: Neutropeni, nedsat neutrofiltal.
English: Insufficient data are available in patients requiring haemodialysis to provide any dose adjustment recommendation in this patient population (see sections 4.4 and 5.2).
Danish: Der foreligger utilstrækkelige data fra patienter som kræver hæmodialyse til at kunne give anbefalinger om dosisjustering til denne patientpopulation (se pkt.
English: Concomitant use of strong CYP3A inhibitors during treatment with palbociclib should be avoided.
Danish: Samtidig administration af potente CYP3A-hæmmere under behandling med palbociclib skal undgås.
English: An increased incidence of a skeletal variation (increased incidence of a rib present at the seventh cervical vertebra) at ≥100 mg/kg/day was observed in rats.
Danish: Der blev observeret en øget forekomst af en skeletvariation hos rotter (øget forekomst af et ribben ved den syvende halshvirvel) ved ≥ 100 mg/kg/dag.
English: The primary endpoint of the study was investigator-assessed PFS evaluated according to RECIST 1.1.
Danish: Studiets primære endepunkt var investigatorvurderet progressionsfri overlevelse (PFS) i henhold til RECIST 1.1.
English: Effects of palbociclib on the pharmacokinetics of other medicinal products
Danish: Virkninger af palbociclib på andre lægemidlers farmakokinetik
English: Palbociclib was foetotoxic in pregnant animals.
Danish: Palbociclib var føtotoksisk hos drægtige dyr.
English: Palbociclib is a weak, time-dependent inhibitor of CYP3A following daily 125 mg dosing at steady state.
Danish: Palbociclib er en svag, tidsafhængig CYP3A-hæmmer ved steady state efter daglig dosering af 125 mg.
English: For patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE is 75 mg once daily on Schedule 3/1 (see sections 4.4 and 5.2).
Danish: Hos patienter med svært nedsat leverfunktion (Child-Pughklasse C), er den anbefalede dosis af IBRANCE 75 mg en gang dagligt i henhold til doseringsplan 3/1 (se pkt.
English: There was no obvious trend in the mean palbociclib fu in human plasma in vivo with worsening renal function.
Danish: Der sås ingen klar tendens i den gennemsnitlige fu af palbociclib i humant plasma in vivo ved forværret nyrefunktion.
English: The effect of palbociclib on the QT interval corrected for heart rate (QTc) interval was evaluated using time matched electrocardiogram (ECG) evaluating the change from baseline and corresponding pharmacokinetic data in 77 patients with advanced breast cancer.
Danish: Palbociclibs virkning på QT-intervallet korrigeret for hjertefrekvens (QTc) blev evalueret hos 77 patienter med fremskreden brystkræft ved hjælp af tidsparrede ændringer i elektrokardiogrammet (EKG), der evaluerede ændringer i forhold til baseline og tilsvarende farmakokinetiske data.
English: Palbociclib is a reversible inhibitor of cyclin-dependent kinases 4 and 6, which are both involved in regulating the cell cycle.
Danish: Palbociclib er en reversibel hæmmer af cyclinafhængig kinase 4 og 6, som begge er involverede i reguleringen af cellecyklussen.
English: IBRANCE is indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer: - in combination with an aromatase inhibitor; - in combination with fulvestrant in women who have received prior endocrine therapy (see section 5.1).
Danish: IBRANCE er indiceret til behandling af hormonreceptor (HR)-positiv, human epidermal vækstfaktorreceptor 2 (HER2)-negativ lokalt fremskreden eller metastatisk brystkræft: - i kombination med en aromatasehæmmer; - i kombination med fulvestrant hos kvinder, som forudgående har fået endokrin terapi (se pkt.
English: The reversibility of the effects on glucose homeostasis, pancreas, eye, kidney, and bone was not established following a 12-week nondosing period, whereas partial to full reversal of effects on the haematolymphopoietic and male reproductive systems, teeth, and adipose tissue was observed.
Danish: Reversibilitet af virkningerne på glucose-homøostase, bugspytkirtel, øjne, nyrer og knogle blev ikke påvist efter en 12-ugers periode uden dosering, men der blev observeret delvis til fuld reversering af virkningerne på blod-lymfesystemet og på hanlige forplantningsorganer, tænder og fedtvæv.
English: Women of childbearing potential or their male partners must use a highly effective method of contraception while taking IBRANCE (see section 4.6).
Danish: Kvinder i den fertile alder og deres mandlige partnere skal anvende en højeffektiv præventionsmetode under behandling med IBRANCE (se pkt.
English: In vitro studies with human hepatocytes, liver cytosolic and S9 fractions, and recombinant sulphotransferase (SULT) enzymes indicated that CYP3A and SULT2A1 are mainly involved in the metabolism of palbociclib.
Danish: In vitro-studier med humane hepatocytter, lever-cytosol og S9-fraktioner og rekombinant sulfotransferase-(SULT) enzymer viste, at palbociclib hovedsageligt metaboliseres af CYP3A og SULT2A1.
English: Therefore, IBRANCE should be taken with food, preferably a meal (see sections 4.2 and 5.2).
Danish: IBRANCE bør derfor indtages med mad og helst i forbindelse med et måltid (se pkt.
English: Females of childbearing potential who are receiving this medicinal product, or their male partners should use adequate contraceptive methods (e.g., double-barrier contraception) during therapy and for at least 3 weeks or 14 weeks after completing therapy for females and males, respectively (see section 4.5).
Danish: Kvinder i den fertile alder, som får dette lægemiddel, eller deres mandlige partnere, skal anvende en sikker præventionsmetode (fx dobbelt barriere) under behandlingen og i mindst 3 uger eller 14 uger efter endt behandling for henholdsvis kvinder og mænd (se pkt.
English: The observed hazard ratio (HR) was 0.576 (95% confidence interval [CI]: 0.46, 0.72) in favour of palbociclib plus letrozole, with a stratified log-rank test 1-sided p-value of <0.000001.
Danish: Den observerede hazard ratio (HR) var 0,576 (95 % CI: 0,46-0,72) til fordel for palbociclib plus letrozol med en p-værdi på < 0,000001 (1-sidet stratificeret log-rank test).
English: The most common (≥20%) adverse reactions of any grade reported in patients receiving palbociclib in randomised clinical studies were neutropenia, infections, leukopenia, fatigue, nausea, stomatitis, anaemia, diarrhoea, alopecia and thrombocytopenia.
Danish: De hyppigste (≥ 20 %) bivirkninger af enhver grad, der er rapporteret hos patienter, som fik palbociclib i randomiserede kliniske studier, var neutropeni, infektioner, leukopeni, træthed, kvalme, stomatitis, anæmi, diarré, alopeci og trombocytopeni.
English: • Lopinavir, indinavir, nelfinavir, ritonavir, telaprevir, and saquinavir used to treat HIV
Danish: • Lopinavir, indinavir, nelfinavir, ritonavir, telaprevir og saquinavir, som anvendes til behandling af hiv-infektion og AIDS.
English: Secondary efficacy endpoints
Danish: Sekundære endepunkter*
English: • Quinidine generally used to treat heart rhythm problems.
Danish: • Kinidin, som normalt anvendes til behandling af problemer med hjerterytmen.