FrancophonIA/ELRC3.0 huggingface dataset:
English: Investigations common atypical lymphocytes, elevations in liver enzymes (AST, ALT), blood triglycerides increased, lipase increased, blood pancreatic amylase uncommon absolute neutrophil count decreased, alkaline phosphatase increased, blood albumin decreased, blood amylase increased, blood bilirubin increased, blood cholesterol increased, blood creatinine increased, blood glucose increased, blood urea nitrogen increased, creatine phosphokinase increased, fasting blood glucose increased, glucose urine present, high density lipoprotein increased, international normalised ratio increased, low density lipoprotein increased, platelet count decreased, red blood cells urine positive, waist circumference increased, weight increased, white blood cell count decreased
Danish: Reduceret absolut neutrofilværdi, forhøjet alkalisk fosfatase, fald i albumin, forhøjet blodamylase, forhøjet bilirubin i blodet, forhøjet kolesteroltal, stigning i serumkreatinin, stigning i blodsukker, stigning i karbamidkvælstof, forhøjet kreatinfosfokinase, stigning i fasteblodsukker, sukker i urinen, stigning i HDL, forhøjet international normaliseret ratio (INR), stigning i LDL, fald i antal blodplader, positiv test for røde blodlegemer i urinen, øget abdominalomfang, vægtøgning, fald i antal hvide blodlegemer.
English: Therefore no dose adjustment of DUTREBIS is required.
Danish: Dosisjustering af DUTREBIS er derfor ikke nødvendig.
English: No dose adjustment required for DUTREBIS or maraviroc.
Danish: Dosisjustering af DUTREBIS eller maraviroc er ikke nødvendig.
English: The major circulating entity was raltegravir and represented approximately 70 % of the total radioactivity; the remaining radioactivity in plasma was accounted for by raltegravir-glucuronide.
Danish: Den primære cirkulerende komponent var raltegravir, som repræsenterede cirka 70% af den samlede radioaktivitet.
English: *The adverse reaction data was collected based on each individual component of DUTREBIS.
Danish: Bivirkningsdata er indsamlet for hver enkelt komponent i DUTREBIS.
English: • erectile dysfunction; breast enlargement in men; menopausal symptoms
Danish: • Impotens, brystforstørrelse hos mænd, symptomer på overgangsalder
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY
Danish: B. BETINGELSER ELLER BEGRÆNSNINGER VEDRØRENDE
English: • back pain; pain in bone/muscle; muscle tenderness or weakness; neck pain; pain in arms or legs; inflammation of the tendons; decrease in the amount of minerals in the bone
Danish: • Rygsmerter, smerter i knogler/muskler, muskelømhed eller -svaghed, nakkesmerter, smerter i arme eller ben, senebetændelse, nedsat mængde af knoglemineral
English: No dose adjustment required for DUTREBIS or boceprevir.
Danish: Dosisjustering af DUTREBIS eller boceprevir er ikke nødvendig.
English: DUTREBIS should not be given in patients with a creatinine clearance of <50 ml/min.
Danish: DUTREBIS bør ikke gives til patienter med en kreatininclearance på <50 ml/min.
English: In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after HIV treatment is started.
Danish: Nogle patienter med fremskreden hiv-infektion, som tidligere har haft en type infektion, der kun forekommer under særlige betingelser (opportunistisk infektion), kan få tegn og symptomer på betændelse fra tidligere infektioner.
English: Table 2 Efficacy Outcome at Weeks 48 and 96
Danish: Effektresultat ved uge 48 og 96
English: Do not stop taking it
Danish: Hold ikke op med at tage lægemidlet da:
English: Concomitant use of
Danish: Derfor frarådes samtidig brug af
English: uncommon gastritis, abdominal discomfort, abdominal pain upper, abdominal tenderness, anorectal discomfort, constipation, dry mouth, epigastric discomfort, erosive duodenitis, eructation, gastrooesophageal reflux disease, gingivitis, glossitis, odynophagia, pancreatitis, peptic ulcer,
Danish: Gastritis, abdominale gener, øvre abdominal smerte, abdominal ømhed, anorektale gener, obstipation, mundtørhed, epigastrisk ubehag, erosiv duodenit, eructatio, gastroøsofageal refluks, gingivit, glossit, odynofagi, pankreatitis, ulcus pepticum, rektalblødning
English: Tell your doctor, pharmacist or nurse if you notice any of the side effects above.
Danish: Fortæl det til lægen, apotekspersonalet eller sundhedspersonalet, hvis du bemærker nogen af ovennævnte
English: In intravenous studies with lamivudine, the mean volume of distribution is 1.3 l/kg.
Danish: Det gennemsnitlige fordelingsvolumen er 1,3 l/kg ifølge intravenøse studier med lamivudin.
English: Serious side effects
Danish: 4.8 Bivirkninger
English: Advice on missed doses
Danish: Anbefaling vedrørende glemte doser
English: As demonstrated in healthy volunteers administered single oral doses of raltegravir in the fasted state, raltegravir AUC and Cmax increase dose proportionally over the dose range 100 mg to 1,600 mg.
Danish: Som vist hos raske, frivillige forsøgspersoner, der fik en enkelt oral dosis raltegravir under faste, øgedes raltegravir AUC og Cmax proportionalt med dosis i dosisintervallet 100 mg til 1.600 mg. I dosisintervallet 100 mg-800 mg øgede raltegravir C12t proportionalt med dosis, men dosisproportionaliteten var lidt mindre end for dosisintervallet 100 mg-1.600 mg. Dosisproportionalitet er ikke klarlagt hos patienter.
English: Please refer to the SmPC for the individual components of DUTREBIS for dosing instructions.
Danish: Se SmPCet for de enkelte komponenter i DUTREBIS for oplysninger om dosering.
English: • inflammation of liver (hepatitis); When hepatitis causes symptoms, they can include: belly pain; nausea and vomiting; not feeling hungry; jaundice, which is when the skin or
Danish: • Leverbetændelse (hepatitis); når hepatitis giver symptomer, kan disse være: mavesmerter;
English: No dosage adjustment required for DUTREBIS or midazolam.
Danish: Dosisjustering er ikke nødvendig for DUTREBIS eller midazolam.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Danish: Særligt hos patienter med almindeligt anerkendte risikofaktorer, fremskreden hiv-sygdom eller langvarig kombinationsbehandling med antiretrovirale lægemidler er der rapporteret om tilfælde af osteonekrose.
English: Safety and efficacy of lamivudine have not been established in the presence of decompensated liver disease.
Danish: Lamivudins sikkerhed og virkning er ikke fastlagt ved tilstedeværelse
English: Co-administration of raltegravir with aluminium and magnesium antacids resulted in reduced raltegravir plasma levels.
Danish: Samtidig administration af raltegravir og aluminium og magnesiumholdige antacida reducerede raltegravirs plasmakoncentration.
English: The true extent of penetration or relationship with any clinical efficacy is unknown.
Danish: Det reelle omfang af penetrationen og sammenhængen med
English: DUTREBIS should not be given in patients with a creatinine clearance of <50 ml/min
Danish: DUTREBIS bør ikke gives til patienter med kreatininclearance <50 ml/min.
English: ≤ 200 cells/mm
Danish: > 50 og ≤ 200 celler/mm
English: Possible interaction between lamivudine and cladribine due to inhibition of intracellular phosphorylation of cladribine by lamivudine.
Danish: lamivudin og cladribin på grund intracellulære fosforylering af
English: A reduction in renal function may necessitate switching DUTREBIS to a regimen of the individual components (lamivudine and raltegravir).
Danish: Nedsat nyrefunktion kan gøre det nødvendigt at ændre behandling med DUTREBIS til et behandlingsregime opdelt på enkeltkomponenterne (lamivudin og raltegravir).
English: • antacids containing aluminium and/or magnesium - used for heartburn.
Danish: • syreneutraliserende medicin, der indeholder aluminium eller magnesium - anvendes til behandling af for meget mavesyre.
English: • Lactic acidosis is more likely to happen in people who have liver problems, or in people who
Danish: • Personer, der har en leversygdom, eller personer, der er meget overvægtige, især kvinder, udvikler
English: No dose adjustment required for DUTREBIS or methadone.
Danish: Dosisjustering af DUTREBIS eller methadon er ikke nødvendig.
English: Dizziness has been reported in some patients during treatment with regimens containing raltegravir, which may influence some patients' ability to drive and use machines (see section 4.8).
Danish: Svimmelhed kan påvirke patientens evne til at føre motorkøretøj og betjene maskiner (se pkt.
English: DUTREBIS should not be co-administered with rifampicin due to reduced plasma concentrations of raltegravir (see section 4.5); the impact on the efficacy of raltegravir is unknown.
Danish: DUTREBIS bør ikke administreres sammen med rifampicin på grund af nedsat raltegravirplasmakoncentration (se pkt.
English: ≤ 100,000 copies/ml CD4-count ≤ 50 cells/mm > 50 and
Danish: Alle patienter Karakteristika ved baseline Hiv-RNA > 100.000 kopier/ml ≤ 100.000 kopier/ml CD4-celletal ≤ 50 celler/mm
English: Merck Sharp & Dohme B.V. Tel: 0800 99 99 000 (+31 23 5153153) medicalinfo.nl@merck.com
Danish: Tel: 0800 99 99 000 (+31 23 5153153) medicalinfo.nl@merck.com
English: If rifampicin administration cannot be avoided, DUTREBIS may be switched to a regimen of the individual components (lamivudine and raltegravir).
Danish: Hvis administration af rifampicin ikke kan undgås, skal DUTREBIS ændres til et behandlingsregime opdelt på enkeltkomponenterne (lamivudin og raltegravir).
English: Aluminium and magnesium containing antacids reduce raltegravir plasma levels.
Danish: Antacida med aluminium og magnesium reducerer raltegravirs plasmakoncentration.
English: • lactic acidosis - signs include deep, fast, difficult breathing, feeling drowsy, numb or weak arms or legs, feeling or being sick (nausea or vomiting), stomach pain
Danish: • Mælkesyreforgiftning - tegn og symptomer inkluderer dyb, hurtig, besværet vejrtrækning, døsighed, følelseshed eller svaghed i arme eller ben, kvalme eller opkastning, mavesmerter.
English: Co-administration of DUTREBIS with aluminium and/or magnesium containing antacids is not recommended.
Danish: Administration af DUTREBIS sammen med aluminium- og/eller magnesiumholdige antacida frarådes derfor.
English: This is because it is very important not to be without the medicine, even for a short time.
Danish: • Når dine Dutrebis-tabletter er ved at være brugt op, skal du hente flere hos din læge eller på apoteket, fordi det er meget vigtigt ikke at være uden medicin, selv i kort tid.
English: • allergic reaction
Danish: • Snurrende fornemmelse
English: BENCHMRK 1 and BENCHMRK 2 (multi-centre, randomised, double-blind, placebo-controlled studies) evaluated the safety and anti-retroviral activity of raltegravir 400 mg twice daily vs. placebo in a combination with optimized background therapy (OBT), in HIV-infected patients, 16 years or older, with documented resistance to at least 1 medicinal product in each of 3 classes (NRTIs, NNRTIs, PIs) of anti-retroviral therapies.
Danish: BENCHMRK 1 og BENCHMRK 2 (randomiserede, dobbeltblindede, placebokontrollerede multicenterstudier) vurderede sikkerheden og den antiretrovirale aktivitet af raltegravir 400 mg to gange dagligt versus placebo i en kombination med OBT hos hiv-inficerede patienter i alderen 16 år og ældre,
English: No dose adjustment required for DUTREBIS or etravirine.
Danish: Dosisjustering af DUTREBIS eller etravirin er ikke nødvendig.
English: The clinical relevance of such findings remains,
Danish: Den kliniske relevans af disse resultater er dog stadig ikke veldefineret.
English: cladribine /lamivudine
Danish: maraviroc /lamivudin
English: Co-administration of DUTREBIS with aluminium and/or magnesium antacids is not recommended (see section 4.5).
Danish: Samtidig administration af DUTREBIS og aluminium og/eller magnesiumholdige antacida frarådes (se pkt.
English: The mean ratio CSF/serum lamivudine concentration 2-4 hours after oral administration was approximately 0.12.
Danish: 24 timer efter oral administration var det gennemsnitlige forhold mellem lamivudinkoncentrationen i cerebrospinalvæsken og plasma ca. 0,12.
English: /sulfamethoxazole is necessary, unless the patient has renal impairment (see section 4.2).
Danish: Dosisjustering af DUTREBIS eller trimethoprim /sulfamethoxazol er ikke nødvendig, medmindre patienten har nedsat nyrefunktion (se pkt.
English: Developmental toxicity
Danish: Mælkesyreforgiftning
English: Detailed information on this medicine is available on the European Medicines Agency web site:
Danish: Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu.
English: Paediatric population
Danish: Demografi
English: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) efavirenz /raltegravir (raltegravir 400 mg Single Dose)
Danish: LÆGEMIDLER MOD HCV NS3/4A-proteasehæmmere (PI) boceprevir /raltegravir (raltegravir 400 mg enkeltdosis)
English: raltegravir AUC  36 % raltegravir C12hr  21 % raltegravir Cmax  36 %
Danish: raltegravir C12t  21 % raltegravir Cmax  36 %
English: There have been reports of mitochondrial dysfunction in infants exposed in utero and/or post-natally to nucleoside reverse transcriptase inhibitors (see section 4.4).
Danish: Der foreligger rapporter om mitokondriel dysfunktion hos spædbørn, som har været eksponeret for nukleosid-revers-transkriptasehæmmere in utero og/eller
English: 6.1 List of excipients
Danish: 6.2 Uforligeligheder
English: However, if co-administration with rifampicin is unavoidable, DUTREBIS may be switched to a regimen of the individual components (lamivudine and raltegravir).
Danish: Hvis samtidig administration med rifampicin er uundgåelig, kan DUTREBIS ændres til et behandlingsregime opdelt på enkeltkomponenterne (lamivudin og raltegravir).
English: Frequency Lamivudine and/or Raltegravir (alone or in combination with other ART)* tissue disorders uncommon acne, dermatitis acneiforme, dry skin, erythema, facial wasting, hyperhidrosis, lipoatrophy, lipodystrophy acquired, lipohypertrophy, night sweats, prurigo, pruritus, pruritus generalised, rash macular, rash maculo-papular, rash pruritic, skin lesion, urticaria, xeroderma, Stevens Johnson syndrome, drug rash with eosinophilia and systemic symptoms (DRESS)
Danish: Akne, akneiform dermatitis, tør hud, erytem, tab af fedt i ansigtet, hyperhidrose, lipoatrofi, erhvervet lipodystrofi, lipohypertrofi, nattesved, prurigo, pruritus, generaliseret pruritus, makuløst udslæt, makulopapuløst udslæt, kløende udslæt, hudlæsioner, urticaria, xeroderma, Stevens-Johnsons syndrom, lægemiddeludslæt med eosinofili og systemiske symptomer (DRESS)
English: Depression, including suicidal thoughts and behaviours, has been reported in some patients taking raltegravir (one of the medicines in
Danish: Der er rapporteret om depression, herunder selvmordstanker og -adfærd, hos nogle patienter, som tager raltegravir (et af lægemidlerne i Dutrebis), især hos patienter, som tidligere har haft en depression eller en psykisk
English: common dizziness, headache, psychomotor hyperactivity uncommon amnesia, carpal tunnel syndrome, cognitive disorder, disturbance in attention, dizziness postural, dysgeusia, hypersomnia, hypoaesthesia, lethargy, memory impairment, migraine, neuropathy peripheral, paraesthesia, somnolence, tension headache, tremor, poor quality uncommon palpitations, sinus bradycardia, ventricular extrasystoles common abdominal distention, diarrhoea, flatulence, nausea, vomiting,
Danish: Amnesi, karpaltunnelsyndrom, kognitiv forstyrrelse, opmærksomhedsforstyrrelse, postural svimmelhed, dysgeusi, hypersomnia, hypæstesi, letargi, hukommelsessvækkelse, migræne, perifer neuropati, paræstesi, døsighed, spændingshovedpine, tremor, dårlig søvnkvalitet
English: • pain in the upper part of the belly; rectal discomfort; constipation; dry mouth; heartburn; pain when swallowing; inflammation of the pancreas (pancreatitis); ulcer or sore in stomach or upper intestine; bleeding from anus; stomach discomfort; inflammation of the
Danish: • Smerter i øverste del af maven, gener i endetarmen, forstoppelse, mundtørhed, halsbrand, synkesmerter, betændelse i bugspytkirtlen (pankreatitis), sår eller ømhed i maven eller øvre del af mave-tarm-kanalen, blødning fra endetarmen, mavegener, tandkødsbetændelse,
English: If creatinine clearance decreases to <50 ml/min, DUTREBIS should be switched to a regimen of the individual components (lamivudine and raltegravir).
Danish: Hvis kreatininclearance falder til <50 ml/min, skal DUTREBIS ændres til et behandlingsregime med de enkelte komponenter (lamivudin og raltegravir).
English: Interaction not studied calcium carbonate antacid /raltegravir (raltegravir 400 mg Twice Daily)
Danish: etravirine /raltegravir (raltegravir 400 mg to gange dagligt)
English: • bloating; excessive gas in the stomach or bowel; indigestion; belching
Danish: • Oppustethed, usædvanlig meget luft i mave eller tarme, fordøjelsesproblemer, opstød
English: Merck Sharp & Dohme s.r.o.
Danish: Merck Sharp & Dohme d.o.o.
English: • harsh, raspy, or strained voice; nosebleed; nasal congestion
Danish: • Grov, hæs eller anstrengt stemme, næseblod, stoppet næse
English: Please refer to the SmPC for the individual components of DUTREBIS for dosing instructions (see section 4.4).
Danish: Se produktresuméet for de enkelte komponenter i DUTREBIS vedrørende oplysninger om dosering (se pkt.
English: 2 and above
Danish: 4.4 og
English: • liver problems, such as yellowing of the skin or whites of the eyes, swollen or fatty liver • blood test showing an increase in an enzyme called amylase
Danish: • Blodprøver som viser en stigning i et enzym, der kaldes amylase
English: No study has been performed with DUTREBIS in subjects with renal insufficiency.
Danish: Der er ikke udført studier med DUTREBIS hos forsøgspersoner med nedsat leverfunktion.
English: Musculoskeletal common arthralgia, muscle disorders uncommon arthritis, back pain, flank pain, musculoskeletal pain, myalgia, neck pain, osteopenia, pain in extremity, tendonitis, rhabdomyolysis uncommon renal failure, nephritis, nephrolithiasis, nocturia, renal cyst, renal uncommon erectile dysfunction, gynaecomastia, menopausal symptoms uncommon chest discomfort, chills, face oedema, fat tissue increased, feeling jittery, submandibular mass, oedema peripheral, pain
Danish: Artrit, rygsmerter, lændesmerter, smerter i knogler, led og muskler, myalgi, nakkesmerter, osteopeni, smerter i ekstremiteterne, tendinitis, rabdomyolyse Nyresvigt, nefritis, nefrolitiasis, nykturi, nyrecyste, nedsat nyrefunktion, tubulo-interstitiel nefritis Erektil dysfunktion, gynækomasti, menopausesymptomer
English: trimethoprim PK ↔ sulfamethoxazole PK ↔
Danish: methadon AUC ↔ methadon Cmax ↔
English: If creatinine clearance decreases to <50 ml/min, DUTREBIS should be switched to a regimen of the individual components (lamivudine and raltegravir) (see section 4.2).
Danish: Hvis kreatininclearance falder til <50 ml/min, skal behandling med DUTREBIS ændres til et behandlingsregime opdelt på enkeltkomponenterne (lamivudin og raltegravir) (se pkt.
English: No dosage adjustment is necessary when these agents are given together.
Danish: Dosisjustering er ikke nødvendig, når
English: • kidney stones; urination at night; kidney cyst
Danish: • Nyresten, natlig vandladning, nyrecyster
English: Tell your doctor, pharmacist or nurse immediately if you notice any symptoms of infection, such
Danish: Fortæl det straks til lægen, apotekspersonalet eller sundhedspersonalet, hvis du bemærker symptomer
English: Frequency Lamivudine and/or Raltegravir (alone or in combination with other ART)* uncommon genital herpes, folliculitis, gastroenteritis, herpes simplex, herpes virus infection, herpes zoster, influenza, lymph node abscess, molluscum contagiosum, nasopharyngitis, upper respiratory tract uncommon iron deficiency anaemia, lymph node pain, lymphadenopathy, neutropenia and anaemia (both occasionally severe),
Danish: Genital herpes, folliculitis, gastroenteritis, herpes simplex, herpes virusinfektion, herpes zoster, influenza, byld i lymfeknude, molluscum contagiosum, nasofaryngitis, øvre luftvejsinfektion
English: Lactic acidosis
Danish: HORMONEL ANTIKONCEPTION Ethinylestradiol
English: Pregnancy and breast-feeding
Danish: Hedeture, hypertension
English: raltegravir AUC  55 % raltegravir C12 hr  32 % raltegravir Cmax  52 %
Danish: raltegravir AUC  4 % raltegravir C12t  25 % raltegravir Cmax  11 %
English: Metabolism and nutrition disorders common decreased appetite uncommon cachexia, diabetes mellitus, dyslipidaemia, hypercholesterolaemia, hyperglycaemia, hyperlipidaemia, hyperphagia, increased appetite, polydipsia, body fat disorder
Danish: Kakeksi, diabetes mellitus, dyslipidæmi, hyperkolesterolæmi, hyperglykæmi, hyperlipidæmi, hyperfagi, øget appetit, polydipsi, unormal fordeling af kropsfedt Almindelig Unormale drømme, insomni, mareridt, unormal adfærd,
English: IT
Danish: IE
English: No dose adjustment required for DUTREBIS.
Danish: Dosisjustering af DUTREBIS er ikke nødvendig.
English: The clinical significance of these findings is
Danish: Den kliniske betydning af disse fund kendes ikke.
English: zidovudine Cmax  28 % zidovudine AUC ↔
Danish: etravirin AUC  10 %
English: If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Danish: Er du i tvivl, så spørg lægen, apotekspersonalet eller sundhedspersonalet.
English: aluminium and magnesium hydroxide antacid /lamivudine
Danish: Filmovertræk Hypromellose Lactosemonohydrat Triacetin
English: Rare (may affect up to 1 in 1,000 people) • serious allergic reaction causing swelling of the face, tongue or throat which may cause
Danish: • Alvorlig allergisk reaktion, der fører til hævelse af ansigt, tunge eller hals, hvilket kan give synkebesvær eller åndedrætsbesvær
English: 6 hours after raltegravir raltegravir AUC  11 % raltegravir C12 hr  49 % raltegravir Cmax  10 %
Danish: raltegravir AUC  10 % raltegravir C12t  34 % raltegravir Cmax  11 %
English: Anti-retroviral Pregnancy Registry
Danish: Tidligere antiretroviral behandling iht.
English: HIV is the virus that causes Acquired Immune Deficiency Syndrome (AIDS).
Danish: Hiv er det virus, som forårsager
English: • cladribine - used to treat hairy cell leukaemia.
Danish: • cladribin - anvendes til behandling af hårcelleleukæmi (en sjælden kræftform, der udvikler sig langsomt i blod og knoglemarv).
English: Breastfeeding is not recommended while taking DUTREBIS.
Danish: Amning frarådes under behandling med DUTREBIS.
English: trimethoprim /sulfamethoxazole /raltegravir
Danish: Ethinylestradiol Norelgestromin /lamivudin
English: • liver failure (the liver stops working , which may cause heavy bleeding, swelling, and
Danish: • opkastning; manglende appetit; gulsot som er, når huden eller det hvide i øjnene bliver gult • Leversvigt (leveren holder op med at fungere, hvilket kan medføre kraftig blødning, hævelse
English: HIV-RNA > 100,000 copies/ml
Danish: Procent hiv-RNA < 400 kopier/ml (95% CI)
English: Mitochondrial dysfunction
Danish: Osteonekrose
English: No dose adjustment required for DUTREBIS or zidovudine.
Danish: Dosisjustering af DUTREBIS eller zidovudin er ikke nødvendig.
English: The effect of severe hepatic insufficiency on the pharmacokinetics of raltegravir has not been studied (see sections 4.2 and 4.4).
Danish: Effekten af svært nedsat leverfunktion på raltegravirs farmakokinetik er ikke undersøgt
English: Overall, considerable inter- and intra-subject variability was observed in the pharmacokinetics of raltegravir (see sections 4.5 and 5.2).
Danish: Virologisk svigt og udvikling af resistens Der er set betydelig inter- og intra-individuel variabilitet i raltegravirs farmakokinetik (se pkt.
English: Tel: +39 06 361911 medicalinformation.it@merck.com
Danish: Tel: + 385 1 66 11 333 croatia_info@merck.com
English: Dose proportionality
Danish: Uforsætlig overdosering
English: • fat may be lost from the legs, arms or face; extra fat may build up around the tummy, breasts or internal organs; fatty lumps (sometimes called buffalo hump) may appear on the back of the neck.
Danish: Fedtpukler (nogle gange kaldet bøffelnakke) kan vise sig i nakken.