FrancophonIA/ELRC3.0 huggingface dataset:
English: Since decreased concentrations of artemether, dihydroartemisinin, or lumefantrine may result in a decrease of antimalarial efficacy, caution is recommended when efavirenz and artemether/lumefantrine tablets are coadministered.
Slovenian: Pri sočasni uporabi efavirenza in tablet z artemetrom/lumefantrinom priporočamo previdnost, ker zmanjšanje koncentracij artemetra, dihidroartemizinina ali lumefantrina lahko povzroči manjšo učinkovitost antimalarikov.
English: one 100 mg capsule + one 50 mg capsule
Slovenian: ena 100 mg kapsula + ena 50 mg kapsula
English: SUSTIVA 50 mg hard capsules
Slovenian: SUSTIVA 50 mg trde kapsule
English: ACID REDUCING AGENTS Aluminium hydroxide-magnesium hydroxide-simethicone antacid/Efavirenz (30 ml single dose/400 mg single dose)
Slovenian: ZDRAVILA ZA KISLINSKO POGOJENE BOLEZNI aluminijev hidroksidni-magnezijev hidroksidni-simetikonijev antacid/efavirenz (enkratni odmerek 30 ml/enkratni odmerek 400 mg) famotidin/efavirenz (enkratni odmerek 40 mg/enkratni odmerek 400 mg)
English: INFORMATION IN BRAILLE SUSTIVA 600 mg
Slovenian: PODATKI V BRAILLOVI PISAVI SUSTIVA 600 mg
English: Printing ink
Slovenian: Črnila za potisk.
English: Concomitant administration of velpatasvir/sofosbuvir/ voxilaprevir with efavirenz is not recommended (see section 4.5).
Slovenian: Sočasne uporabe efavirenza in velpatasvira/sofosbuvira/voksilaprevira ne priporočamo (glejte poglavje 4.5).
English: Each hard capsule contains 57.0 mg of lactose (as monohydrate).
Slovenian: Pomožne snovi z znanim učinkom Ena trda kapsula vsebuje 57,0 mg laktoze (v obliki monohidrata).
English: B. PACKAGE LEAFLET
Slovenian: BESEDILO NA PRETISNEM OMOTU
English: Women of childbearing potential should undergo pregnancy testing before initiation of efavirenz.
Slovenian: Ženske v rodni dobi morajo pred začetkom zdravljenja z efavirenzem opraviti nosečnostni test (glejte poglavje 5.3).
English: Concomitant use of Ginkgo biloba extracts is not recommended (see section 4.4).
Slovenian: Sočasna uporaba izvlečkov ginka ni priporočljiva (glejte poglavje 4.4).
English: Voriconazole: AUC: ↓ 7% (↓ 23 to ↑ 13) *
Slovenian: AUC: ↓ 7 % (↓ 23 do ↑ 13)
English: Hard capsule
Slovenian: FARMACEVTSKA OBLIKA trda kapsula
English: EFV + IDV + NRTIs 157 60 (52, 68) IDV + NRTIs a NC = F, noncompleter = failure.
Slovenian: EFV + IDV + NRTI-ji IDV + NRTI-ji a NK = NA, ni končal = napaka analize b
English: If you take too much SUSTIVA contact your doctor or nearest emergency department for advice.
Slovenian: Če ste vzeli večji odmerek zdravila SUSTIVA, kot bi smeli Če vzamete preveč zdravila SUSTIVA, se posvetujte z zdravnikom ali obiščite najbližjo urgenco.
English: Vigabatrin/Efavirenz Gabapentin/Efavirenz
Slovenian: Priporočilo glede sočasne uporabe z efavirenzem vigabatrin/efavirenz gabapentin/efavirenz
English: INFORMATION IN BRAILLE SUSTIVA 200 mg
Slovenian: PODATKI V BRAILLOVI PISAVI SUSTIVA 200 mg
English: The increased efavirenz concentrations observed following administration of efavirenz with food may lead to an increase in frequency of adverse reactions (see sections 4.4. and 5.2).
Slovenian: Pri jemanju efavirenza s hrano so opazili njegovo povečano koncentracijo, kar lahko poveča pogostnost neželenih učinkov (glejte poglavji 4.4. in 5.2).
English: CD4+ cell count was 755 cells/mm3, and median CD4+ percentage was 30%.
Slovenian: CD4+ je bila 238 celic/mm3 in mediana povečanja odstotka celic CD4+ je bila 13 %.
English: Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section
Slovenian: Med protiretrovirusnim zdravljenjem se lahko poveča telesna masa ter zviša koncentracija lipidov in glukoze v krvi (glejte poglavje 4.4).
English: Each hard capsule contains 200 mg of efavirenz.
Slovenian: Ena trda kapsula vsebuje 200 mg efavirenza.
English: Coadministration of glecaprevir/pibrentasvir with efavirenz is not recommended.
Slovenian: Sočasne uporabe efavirenza in glekaprevira/pibrentasvira ne priporočamo.
English: Fluoxetine/Efavirenz
Slovenian: fluoksetin/efavirenz
English: Protease inhibitors (PI) Atazanavir/ ritonavir/Efavirenz (400 mg once daily/100 mg once daily/600 mg once daily, all administered with food)
Slovenian: ZDRAVILA ZA ZDRAVLJENJE INFEKCIJ Zdravila za zdravljenje okužbe s HIV Zaviralci proteaze (ZP) atazanavir/ritonavir/efavirenz (400 mg enkrat na dan/100 mg enkrat na dan/600 mg enkrat na dan, vse s hrano)
English: Implant: Etonogestrel/Efavirenz Decreased exposure of etonogestrel may be expected (CYP3A4 induction).
Slovenian: Lahko pričakujemo zmanjšano izpostavitev etonogestrelu (indukcija CYP3A4).
English: EU/1/99/110/009 - blister
Slovenian: EU/1/99/110/009 - pretisni omot
English: Protease inhibitor : Elbasvir/ grazoprevir
Slovenian: Priporočilo glede sočasne uporabe z efavirenzem infibitor proteaze: elbasvir/grazoprevir
English: ANTICONVULSANTS Carbamazepine/Efavirenz (400 mg once daily/600 mg once daily)
Slovenian: ANTIKONVULZIVI karbamazepin/efavirenz (400 mg enkrat na dan/600 mg enkrat na dan)
English: Body Weight
Slovenian: Telesna masa
English: ANTIHISTAMINES Cetirizine/Efavirenz (10 mg single dose/600 mg once daily)
Slovenian: ANTIHISTAMINIKI cetirizin/efavirenz (enkratni odmerek 10 mg/600 mg enkrat na dan)
English: Taking SUSTIVA on an empty stomach may reduce the undesirable effects.
Slovenian: Zdravilo SUSTIVA skupaj s hrano in pijačo Jemanje zdravila SUSTIVA na tešče lahko zmanjša neželene učinke.
English: Coadministration of glecaprevir/pibrentasvir with efavirenz is not recommended (see section 4.5).
Slovenian: Sočasne uporabe efavirenza in glekaprevira/pibrentasvira ne priporočamo (glejte poglavje 4.5).
English: Rifampicin/Efavirenz (600 mg once daily/600 mg once daily)
Slovenian: rifampicin/efavirenz (600 mg enkrat na dan/600 mg enkrat na dan)
English: Coadministration of sofosbuvir/velpatasvir with efavirenz is not recommended.
Slovenian: Sočasne uporabe efavirenza in sofosbuvira/velpatasvira ne priporočamo.
English: AUC: ↑ 21% (↑ 10 to ↑ 34)
Slovenian: AUC: ↑ 17 % (↑ 6 do ↑ 29)
English: Co-administration of efavirenz with atazanavir/ritonavir is not recommended.
Slovenian: Sočasne uporabe efavirenza in atazanavirja/ritonavirja ne priporočamo.
English: Coadministration of sofosbuvir/velpatasvir with efavirenz is not recommended (see section 4.5).
Slovenian: Sočasne uporabe efavirenza in sofosbuvira/velpatasvira ne priporočamo (glejte poglavje 4.5).
English: EFV + NFV + NRTIs 65 70 (59, 82) EFV + NRTIs
Slovenian: EFV + NFV + NRTI-ji EFV + NRTI-ji NFV + NRTI-ji Študija 020
English: OUTER CARTON AND LABEL TEXT FOR BOTTLE PACK OUTER CARTON TEXT FOR BLISTER PACK
Slovenian: PODATKI NA ZUNANJI OVOJNINI IN PRIMARNI OVOJNINI BESEDILO NA ŠKATLI IN NALEPKI ZA PLASTENKO BESEDILO NA ŠKATLI, V KATERI JE PRETISNI OMOT
English: SUSTIVA 50 mg hard capsules efavirenz
Slovenian: SUSTIVA 50 mg trde kapsule efavirenz
English: Severe rash occurred in less than 1% of patients treated with efavirenz, and 1.7% discontinued therapy because of rash.
Slovenian: Hud izpuščaj se je pojavil pri manj kot 1 % bolnikov, zdravljenih z efavirenzem.
English: SUSTIVA 100 mg hard capsules
Slovenian: SUSTIVA 100 mg trde kapsule
English: Each hard capsule contains 100 mg of efavirenz.
Slovenian: Ena trda kapsula vsebuje 100 mg efavirenza.
English: The median increase from baseline in CD4+ count at 48 weeks of therapy was 128 cells/mm3 and the median increase in CD4+ percentage was 5%.
Slovenian: V 48. tednu mediana povečanja od izhodišča za število celic CD4+ je bila 128 celic/mm in mediana povečanja odstotka celic CD4+ je bila 5 %.
English: The dose for children weighing 40 kg or more is 600 mg once daily.
Slovenian: Filmsko obložene tablete SUSTIVA niso namenjene otrokom, ki tehtajo manj kot 40 kg. Odmerek za otroke, ki tehtajo 40 kg ali več, je 600 mg enkrat na dan
English: Simvastatin/Efavirenz (40 mg once daily/600 mg once daily)
Slovenian: simvastatin/efavirenz (40 mg enkrat na dan/600 mg enkrat na dan)
English: Marketing Authorisation Holder Bristol-Myers Squibb Pharma EEIG Plaza 254
Slovenian: IMETNIK DOVOLJENJA ZA PROMET Z ZDRAVILOM Bristol-Myers Squibb Pharma EEIG Plaza 254
English: Morning Cmin: ↑ 42% (↑ 9 to ↑ 86) b Evening Cmin: ↑ 24% (↑ 3 to ↑ 50) b Efavirenz:
Slovenian: AUC zjutraj: ↑ 18 % (↑ 6 do ↑ 33) AUC zvečer: ↔ Cmax zjutraj: ↑ 24 % (↑ 12 do ↑ 38) Cmax zvečer: ↔ Cmin zjutraj: ↑ 42 % (↑ 9 do ↑ 86)b
English: SUSTIVA 200 mg hard capsules
Slovenian: SUSTIVA 200 mg trde kapsule
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 600 mg film-coated tablets efavirenz
Slovenian: IME ZDRAVILA SUSTIVA 600 mg filmsko obložene tablete efavirenz
English: Each hard capsule contains 50 mg of efavirenz.
Slovenian: Ena trda kapsula vsebuje 50 mg efavirenza.
English: Itraconazole/Efavirenz (200 mg q12h/600 mg once daily)
Slovenian: Antimikotiki itrakonazol/efavirenz (200 mg q12h/600 mg enkrat na dan)
English: Dose related increases in Cmax and AUC were seen for doses up to 1,600 mg; the increases were less than proportional suggesting diminished absorption at higher doses.
Slovenian: Ta zvišanja so bila manj kot sorazmerna, kar nakazuje zmanjšano absorpcijo zdravila pri višjih odmerkih.
English: Fosamprenavir/ritonavir/Efavirenz (700 mg twice daily/100 mg twice daily/600 mg once daily)
Slovenian: fosamprenavir/ritonavir/efavirenz (700 mg dvakrat na dan/100 mg dvakrat na dan/600 mg enkrat na dan)
English: SUSTIVA 100 mg hard capsules efavirenz
Slovenian: SUSTIVA 100 mg trde kapsule efavirenz
English: INFORMATION IN BRAILLE SUSTIVA 100 mg
Slovenian: PODATKI V BRAILLOVI PISAVI SUSTIVA 100 mg
English: Serious psychiatric adverse reactions have been reported in patients treated with efavirenz.
Slovenian: Pri bolnikih, ki so se zdravili z efavirenzem, so poročali o resnih psihiatričnih neželenih učinkih.
English: Psychiatric adverse reactions have been reported in patients treated with efavirenz.
Slovenian: Pri bolnikih, zdravljenih z efavirenzem, so poročali o psihiatričnih neželenih učinkih.
English: Cmax: ↑ 50% (↑ 20 to ↑ 80)
Slovenian: Cmax: ↑ 50 % (↑ 20 do ↑ 80) (indukcija CYP2B6)
English: Paroxetine/Efavirenz (20 mg once daily/600 mg once daily)
Slovenian: paroksetin/efavirenz (20 mg enkrat na dan/600 mg enkrat na dan)
English: OPIOIDS
Slovenian: ZDRAVILOM
English: Cmin: ↓ 47% (↓ 41 to ↓ 53) (decrease in carbamazepine concentrations: CYP3A4 induction; decrease in efavirenz concentrations: CYP3A4 and CYP2B6 induction)
Slovenian: AUC: ↓ 36 % (↓ 32 do ↓ 40) Cmax: ↓ 21 % (↓ 15 do ↓ 26) Cmin: ↓ 47 % (↓ 41 do ↓ 53) (zmanjšanje koncentracij karbamazepina: indukcija CYP3A4; zmanjšanje koncentracij efavirenza: indukcija CYP3A4 in CYP2B6)
English: Breast-feeding should be discontinued during treatment with SUSTIVA.
Slovenian: Med zdravljenjem z efavirenzem je treba dojenje prekiniti.
English: K103N was the most frequently observed RT substitution in viral isolates from patients who experienced a significant rebound in viral load during clinical studies of efavirenz in combination with indinavir or zidovudine + lamivudine.
Slovenian: V virusnih izolatih bolnikov, ki so v kliničnih študijah z efavirenzem v kombinaciji z indinavirjem ali zidovudinom + lamivudinom doživeli znaten povratek virusnega bremena, je bila najpogostejša RT substitucija substitucija K103N.
English: ANTIANXIETY AGENTS Lorazepam/Efavirenz (2 mg single dose/600 mg once daily)
Slovenian: ANKSIOLITIKI lorazepam/efavirenz (enkratni odmerek 2 mg/600 mg enkrat na dan)
English: AUC: ↓ 36% (↓ 32 to ↓ 40)
Slovenian: AUC: ↓ 25 % (↓ 16 do ↓ 32)b
English: Atovaquone and proguanil hydrochloride/Efavirenz (250/100 mg single dose/600 mg once daily)
Slovenian: atovakon in progvanilijev klorid/efavirenz (250/100 mg enkratni odmerek/600 mg enkrat na dan)
English: SUSTIVA can reduce the amount of statins in your blood.
Slovenian: Zdravilo SUSTIVA lahko zmanjša količino statinov v krvi.
English: Valproic acid/Efavirenz (250 mg twice daily/600 mg once daily)
Slovenian: valprojska kislina/efavirenz (250 mg dvakrat na dan/600 mg enkrat na dan)
English: Capsule shell: Gelatine, Sodium laurilsulfate, Yellow iron oxide (E172), Titanium dioxide (E171), Silicon dioxide (E551)
Slovenian: Ovojnica kapsule: želatina, natrijev lavrilsulfat, rumeni železov oksid (E172), titanov dioksid (E171), silicijev dioksid (E551)
English: Cmin: ↓ 45% (↓ 31 to ↓ 56) Efavirenz:
Slovenian: Cmin : ↓ 50 % (↓ 40 do ↓ 59) efavirenz:
English: The dose of lopinavir/ritonavir tablets should be increased to 500/125 mg twice daily when co-administered with efavirenz 600 mg once daily.
Slovenian: Pri jemanju z efavirenzem 600 mg enkrat na dan je treba odmerek lopinavir/ritonavir tablet povečati na 500/125 mg dvakrat na dan. Glejte tudi informacije za ritonavir v nadaljevanju.
English: Propylene glycol
Slovenian: Propilenglikol
English: Liver enzyme monitoring should be considered for patients without pre-existing hepatic dysfunction or other risk factors.
Slovenian: Pri bolnikih brez predhodne motnje v delovanju jeter ali drugih dejavnikov tveganja je treba po potrebi spremljati jetrne encime.
English: (CYP3A4 enzyme induction)
Slovenian: (indukcija CYP3A4) *v primerjavi z atazanavirjem
English: There is no experience in patients with severe renal failure and close safety monitoring is recommended in this population.
Slovenian: Izkušenj pri bolnikih s hudo ledvično okvaro ni.
English: Fluconazole/Efavirenz (200 mg once daily/400 mg once daily)
Slovenian: flukonazol/efavirenz (200 mg enkrat na dan/400 mg enkrat na dan)
English: Caution must be taken in any patient with a history of seizures.
Slovenian: Pri vseh bolnikih z anamnezo napadov krčev je potrebna previdnost.
English: Efavirenz: AUC: ↔
Slovenian: Efavirenz odmerek (mg)
English: Indinavir/ritonavir/Efavirenz (800 mg twice daily/100 mg twice daily/600 mg once daily)
Slovenian: indinavir/ritonavir/efavirenz (800 mg dvakrat na dan/100 mg dvakrat na dan/600 mg enkrat na dan)
English: CARDIOVASCULAR AGENTS Calcium Channel Blockers Diltiazem/Efavirenz (240 mg once daily/600 mg once daily)
Slovenian: ZDRAVILA ZA BOLEZNI SRCA IN OŽILJA Zaviralci kalcijevih kanalčkov diltiazem/efavirenz (240 mg enkrat na dan/600 mg enkrat na dan)
English: Cmin: ↓ 8% (↑ 14 to ↓ 25) Norelgestromin (active metabolite): AUC: ↓ 64% (↓ 62 to ↓ 67)
Slovenian: Cmin: ↓ 8 % (↑ 14 do ↓ 25) norelgestromin (aktivni presnovek):
English: Women should not get pregnant during treatment with SUSTIVA and for 12 weeks thereafter.
Slovenian: Ženske med jemanjem in 12 tednov po prenehanju jemanja zdravila SUSTIVA ne smejo zanositi.
English: The pharmacokinetics of efavirenz have not been studied in patients with renal insufficiency; however, less than 1% of an efavirenz dose is excreted unchanged in the urine, so the impact of renal impairment on efavirenz elimination should be minimal (see section 4.2).
Slovenian: Pri bolnikih z ledvično insuficienco niso preučevali farmakokinetike efavirenza, vendar se manj kot 1 % odmerka efavirenza izloči nespremenjenega z urinom.
English: Voriconazole/Efavirenz (400 mg twice daily/300 mg once daily)
Slovenian: vorikonazol/efavirenz (400 mg dvakrat na dan/300 mg enkrat na dan)
English: SUSTIVA 200 mg hard capsules efavirenz
Slovenian: SUSTIVA 200 mg trde kapsule efavirenz
English: Skin rash was considered treatment related in 18% of patients treated with efavirenz.
Slovenian: Pri 18 % bolnikov, zdravljenih z efavirenzem, so menili, da je pojav izpuščaja povezan z zdravljenjem.
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 50 mg hard capsules efavirenz
Slovenian: IME ZDRAVILA SUSTIVA 50 mg trde kapsule efavirenz
English: No malformations were observed in foetuses from efavirenz-treated rats and rabbits.
Slovenian: Pri zarodkih samic podgan in kuncev, ki so dobivale efavirenz, niso opazili malformacij.
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 200 mg hard capsules efavirenz
Slovenian: IME ZDRAVILA SUSTIVA 200 mg trde kapsule efavirenz
English: Each hard capsule contains 114.0 mg of lactose (as monohydrate).
Slovenian: Pomožne snovi z znanim učinkom Ena trda kapsula vsebuje 114 mg laktoze (v obliki monohidrata).
English: Dose adjustment of pravastatin may be required (refer to the Summary of Product Characteristics for pravastatin).
Slovenian: Morda je treba prilagoditi odmerek pravastatina (glejte Povzetek glavnih značilnosti zdravila za pravastatin).
English: Symptoms including, but not limited to, dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming are frequently reported adverse reactions in patients receiving efavirenz 600 mg daily in clinical studies (see section 4.8).
Slovenian: V kliničnih študijah pri bolnikih, ki so jemali 600 mg efavirenza na dan, so pogosto poročali o neželenih učinkih, ki so vključevali tudi naslednje simptome: omotico, nespečnost, zaspanost, moteno koncentracijo in nenormalne sanje (glejte poglavje 4.8).
English: Table 5: Predicted steady-state pharmacokinetics of efavirenz (capsules/capsule sprinkles) in HIV-infected paediatric patients
Slovenian: Preglednica 5: Predvidena farmakokinetika efavirenza v stanju dinamičnega ravnovesja
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 100 mg hard capsules efavirenz
Slovenian: IME ZDRAVILA SUSTIVA 100 mg trde kapsule efavirenz
English: Injection:
Slovenian: simvastatin:
English: No dose adjustment is necessary for efavirenz when given with indinavir or indinavir/ritonavir.
Slovenian: Pri jemanju z indinavirjem ali indinavirjem/ritonavirjem prilagoditev odmerka efavirenza ni potrebna.
English: Telaprevir (relative to 750 mg q8h): AUC: ↓ 18% (↓ 8 to ↓ 27) Cmax: ↓ 14% (↓ 3 to ↓ 24)
Slovenian: AUC: ↓ 18 % (↓ 8 do ↓ 27) Cmax: ↓ 14 % (↓ 3 do ↓ 24) Cmin: ↓ 25 % (↓ 14 do ↓
English: Cmin: ↓ 86% (↓ 80 to ↓ 90) (induction of metabolism) Efavirenz: no clinically significant interaction.
Slovenian: AUC: ↓ 83 % (↓ 79 do ↓ 87) Cmax: ↓ 80 % (↓ 77 do ↓ 83) Cmin: ↓ 86 % (↓ 80 do ↓ 90) (indukcija presnove) efavirenz: Ni klinično pomembnih interakcij.
English: Table 4: Predicted steady-state pharmacokinetics of efavirenz (capsules/capsule sprinkles) in HIV-infected paediatric patients Body Weight
Slovenian: Preglednica 4: Predvidena farmakokinetika efavirenza v stanju dinamičnega ravnovesja
English: Printing ink: Cochineal carminic acid (E120), Indigo carmine (E132), Titanium dioxide (E171)
Slovenian: Črnila za potisk: karminska kislina (E120), indigotin (E132), titanov dioksid (E171) SUSTIVA 200 mg trde kapsule
English: Each SUSTIVA hard capsule contains 200 mg of the active substance efavirenz.
Slovenian: Ena trda kapsula zdravila SUSTIVA vsebuje 200 mg učinkovine efavirenza.
English: AUC: ↓ 18% (↓ 10 to ↓ 26) Cmax: ↓ 24% (↓ 15 to ↓ 32)
Slovenian: AUC: ↓ 40 % (↓ 26 do ↓ 57) Cmax: ↓ 18 % (↓ 59 do ↑ 12)
English: Dose (mg)
Slovenian: SUSTIVA odmerek (mg)
English: The median increase from baseline in CD4+ count at 48 weeks was 215 cells/mm and the median increase in CD4+ percentage was 6%.
Slovenian: V 48. tednu mediana povečanja od izhodišča v številu celic CD4+ je znašala 215 celic/mm in mediana povečanja odstotka celic CD4+ je znašala
English: Each SUSTIVA hard capsule contains 50 mg of the active substance efavirenz.
Slovenian: Ena trda kapsula zdravila SUSTIVA vsebuje 50 mg učinkovine efavirenza.
English: Cmin: ↓ 62% (↓ 44 to ↓ 75) N-monodesmethyl diltiazem: AUC: ↓ 37% (↓ 17 to ↓ 52)
Slovenian: AUC: ↓ 75 % (↓ 59 do ↓ 84) Cmax: ↓ 64 % (↓ 57 do ↓ 69) Cmin: ↓ 62 % (↓ 44 do ↓ 75) N-monodesmetil-diltiazem: AUC: ↓ 37 % (↓ 17 do ↓ 52) Cmax: ↓ 28 % (↓ 7 do ↓ 44) Cmin: ↓ 37 % (↓ 17 do ↓ 52) efavirenz:
English: AUC: ↓ 36% C12: ↓ 21%
Slovenian: AUC: ↓ 36 % C12: ↓ 21 % Cmax: ↓ 36 % (indukcija UGT1A1)
English: Lopinavir/ritonavir tablets/ Efavirenz (400/100 mg twice daily/600 mg once daily) (500/125 mg twice daily/600 mg once daily)
Slovenian: Priporočilo glede sočasne uporabe z efavirenzem lopinavir/ritonavir mehke kapsule ali peroralna raztopina/efavirenz lopinavir/ritonavir tablete/efavirenz (400/100 mg dvakrat na dan/600 mg enkrat na dan) (500/125 mg dvakrat na dan/600 mg enkrat na dan)
English: Each SUSTIVA hard capsule contains 100 mg of the active substance efavirenz.
Slovenian: Ena trda kapsula zdravila SUSTIVA vsebuje 100 mg učinkovine efavirenza.
English: Seizures
Slovenian: Dojenje
English: Cmin: ↓ 44%
Slovenian: Cmin: ↓ 44 % efavirenz:
English: Dark yellow, printed with "SUSTIVA" on the body and "200 mg" on the cap.
Slovenian: Trde kapsule so bele barve in imajo napis »SUSTIVA« na enem in "200 mg" na drugem delu.
English: The capsule shell contains: gelatine, sodium laurilsulfate, yellow iron oxide (E172), titanium dioxide (E171) and silicon dioxide.
Slovenian: Ovojnica kapsule vsebuje: želatino, natrijev lavrilsulfat, rumeni železov oksid (E172), titanov dioksid (E171) in silicijev dioksid (E551).
English: Telaprevir/Efavirenz (1,125 mg q8h/600 mg once daily)
Slovenian: Priporočilo glede sočasne uporabe z efavirenzem telaprevir/efavirenz (1,125 mg q8h/600 mg enkrat na dan)
English: Cmax: ↑ 23% (↓ 1 to ↑ 53) *
Slovenian: Cmax: ↑ 23 % (↓ 1 do ↑ 53) * efavirenz:
English: Treatment Regimend n
Slovenian: Režim zdravljenjad
English: Component of a multipack, can't be sold separately.
Slovenian: Ni za posamično prodajo.
English: At baseline, median plasma HIV-1 RNA was 4.57 log10 copies/mL, median
Slovenian: Ob izhodišču je ugotovljeno: mediana plazemsko HIV-1 RNA je bila 4,57 log10 kopij/ml, mediana števila celic CD4+ je bila 755 celic/mm3
English: Cmax: ↑ 49% (↑ 32 to ↑ 69)
Slovenian: AUC: ↑ 34 % (↑ 18 do ↑ 53) Cmax: ↑ 49 % (↑ 32 do ↑ 69) efavirenz:
English: AUC: ↓ 34% (↓ 21 to ↓ 41)
Slovenian: AUC: ↓ 34 % (↓ 21 do ↓ 41) Cmax: ↓ 20 % (↓ 2 do ↓ 26)
English: Mean percent change in AUC, Cmax,
Slovenian: Učinki na koncentracije učinkovin Srednja sprememba AUC, Cmax, Cmin z intervali zaupanja, če so na voljoa
English: Cmax: ↓ 44% (↓ 20 to ↓ 61)
Slovenian: AUC: ↓ 75 % (↓ 62 do ↓ 84) Cmax: ↓ 44 % (↓ 20 do ↓ 61)
English: Cmin: ↑ 12%*/** (↓16 to ↑49) (CYP3A4 induction).
Slovenian: Cmax: ↑ 11 % (↑ 6 do ↑ 16) Cmin: ↔ (indukcija CYP3A4)
English: AUC: ↓ 21% Cmax: ↔
Slovenian: AUC: ↓ 21 % Cmax: ↔ efavirenz:
English: Voriconazole/Efavirenz (200 mg twice daily/400 mg once daily)
Slovenian: vorikonazol/efavirenz (200 mg dvakrat na dan/400 mg enkrat na dan)
English: Proguanil: AUC: ↓ 43% (↓ 7 to ↓ 65)
Slovenian: AUC: ↓ 43 % (↓ 7 do ↓ 65) Cmax: ↔
English: Darunavir/ritonavir/Efavirenz (300 mg twice daily*/100 mg twice daily/600 mg once daily)
Slovenian: **temelji na pretekli primerjavi darunavir/ritonavir/efavirenz (300 mg dvakrat na dan*/100 mg dvakrat na dan/600 mg enkrat na dan)
English: Efavirenz: AUC: ↑ 17% (↑ 6 to ↑ 29) **
Slovenian: AUC: ↔* (↓ 9 do ↑ 10) Cmax: ↑ 17 %* (↑ 8 do ↑ 27) Cmin : ↓ 42 %* (↓ 31 do
English: Posaconazole/Efavirenz --/400 mg once daily
Slovenian: posakonazol/efavirenz --/400 mg enkrat na dan posakonazol:
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING
Slovenian: Izgled zdravila SUSTIVA in vsebina pakiranja
English: Azithromycin/Efavirenz (600 mg single dose/400 mg once daily)
Slovenian: Antibiotiki azitromicin/efavirenz (enkratni odmerek 600 mg/400 mg enkrat na dan)
English: Cmax: ↑ 16% (↑ 2 to ↑ 32)
Slovenian: Cmin zvečer: ↑ 24 % (↑ 3 do
English: Antimycobacterials Rifabutin/Efavirenz (300 mg once daily/600 mg once daily)
Slovenian: Zdravila za zdravljenje okužb z mikobakterijami rifabutin/efavirenz (300 mg enkrat na dan/600 mg enkrat na dan)
English: Cmin: ↓ 37% (↓ 17 to ↓ 52) Efavirenz:
Slovenian: Cmax : ↓ 17 % (↓ 6 do ↓ 26) Cmin : ↓ 50 % (↓ 40 do ↓ 59) efavirenz:
English: Co-administration of simeprevir with efavirenz is not recommended.
Slovenian: Sočasne uporabe simeprevirja z efavirenzem ne priporočamo.
English: ANTI-INFECTIVES HIV antivirals
Slovenian: a) plazemska HIV-RNA
English: Cmin: ↓ 44% (↓ 27 to ↓ 58) (decrease in itraconazole concentrations: CYP3A4 induction) Hydroxyitraconazole:
Slovenian: AUC: ↓ 39 % (↓ 21 do ↓ 53) Cmax: ↓ 37 % (↓ 20 do ↓ 51) Cmin: ↓ 44 % (↓ 27 do ↓ 58) (zmanjšanje koncentracij itrakonazola: indukcija CYP3A4) hidroksiitrakonazol:
English: Cmin: ↓ 82% (↓ 79 to ↓ 85) Levonorgestrel (active metabolite): AUC: ↓ 83% (↓ 79 to ↓ 87)
Slovenian: AUC: ↓ 64 % (↓ 62 do ↓ 67) Cmax: ↓ 46 % (↓ 39 do ↓ 52) Cmin: ↓ 82 % (↓ 79 do ↓ 85) levonorgestrel (aktivni presnovek):
English: Ethinyloestradiol: AUC: ↔
Slovenian: etinilestradiol:
English: Norbuprenorphine:
Slovenian: vorikonazol: