FrancophonIA/ELRC3.0 huggingface dataset:
English: Based on an analysis of population pharmacokinetics in phase II trials, co-administration of dexamethasone, prochlorperazine, phenytoin, carbamazepine, ondansetron, H2 receptor antagonists, or phenobarbital did not alter the clearance of TMZ.
Danish: På basis af en analyse af populationsfarmakokinetik i fase II-undersøgelser, ændrede samtidig anvendelse af dexamethason, prochlorperazin, phenytoin, carbamazepin, ondansetron, H2-receptorantagonister eller phenobarbital ikke udskillelsen af TMZ.
English: TMZ interruption
Danish: TMZ-afbrydelse
English: Prolonged pancytopenia, aplastic anaemia pancytopenia, petechiae
Danish: Længerevarende pancytopeni, aplastisk anæmi pancytopeni, petekkier
English: The solution should be inspected and any vial containing visible particulate matter should not be used.
Danish: Opløsningen bør inspiceres og hætteglas med synlige partikler bør ikke anvendes.
English: The hard capsules (capsules) for oral use are individually sealed in sachets and dispensed in cartons containing 5 or 20 hard capsules.
Danish: De hårde kapsler (kapslerne) til oral brug pakkes enkeltvis i breve og udleveres i kartoner, der indeholder 5 eller 20 hårde kapsler.
English: Sodium citrate (for pH adjustment) Hydrochloric acid concentrated (for pH adjustment)
Danish: Natriumcitrat (til pH justering) Saltsyre, koncentreret (til pH justering)
English: Temodal 5 mg hard capsules Temodal 20 mg hard capsules Temodal 100 mg hard capsules Temodal 140 mg hard capsules Temodal 180 mg hard capsules Temodal 250 mg hard capsules temozolomide
Danish: Temodal 5 mg hårde kapsler Temodal 20 mg hårde kapsler Temodal 100 mg hårde kapsler Temodal 140 mg hårde kapsler Temodal 180 mg hårde kapsler Temodal 250 mg hårde kapsler temozolomid (temozolomide)
English: Talk to your doctor, pharmacist or nurse before taking Temodal, - as you should be observed closely for the development of a serious form of chest infection called Pneumocystis jirovecii pneumonia (PCP).
Danish: Kontakt lægen, apotekspersonalet eller sygeplejersken, før De tager Temodal, - da De skal opbserveres tæt for udviklingen af en alvorlig form for lungebetændelse kaldet Pneumocystis jirovecii pneumoni (PCP).
English: Skin and subcutaneous tissue disorders Very Common:
Danish: Hud og subkutane væv Meget almindelig:
English: The active substance is temozolomide.
Danish: Aktivt stof: temozolomid.
English: Patients who received concomitant TMZ and RT in a pilot trial for the prolonged 42-day schedule were shown to be at particular risk for developing Pneumocystis jirovecii pneumonia (PCP).
Danish: Patienter, som fik konkomitant TMZ og strålebehandling i en pilotundersøgelse af det længerevarende 42-dages program, viste sig at have særlig risiko for at udvikle Pneumocystis jirovecii lungebetændelse (PCP).
English: Do not take Temodal - if you are allergic to temozolomide or any of the other ingredients of this medicine (listed in section 6).
Danish: Tag ikke Temodal - hvis De er allergisk over for temozolomid eller et af de øvrige indholdsstoffer i Temodal (angivet i punkt 6).
English: Type I amber glass bottles with polypropylene child-resistant closures containing 5 or 20 hard capsules.
Danish: Type I brune glasflasker med polypropylen børnesikrede lukninger indeholdende 5 eller 20 hårde kapsler.
English: C over 7 days post-dose was 0.8 %
Danish: C over 7 dage 0,8 %, hvilket tyder på fuldstændig absorption.
English: - if you have liver or kidney problems, your dose of Temodal may need to be adjusted.
Danish: - hvis De har problemer med leveren eller nyrerne, skal Deres Temodal-dosis muligvis justeres.
English: Four weeks after completing the TMZ + RT concomitant phase, TMZ is administered for up to 6 cycles of monotherapy treatment.
Danish: Fire uger efter fuldført TMZ + strålebehandling indgives TMZ i op til 6 serier af monoterapibehandling.
English: Behaviour disorder, emotional lability, hallucination, apathy
Danish: Ændret opførsel, emotionel labilitet, hallucination, apati
English: Anti-emetic therapy may be administered prior to or following administration of TMZ.
Danish: Antiemetisk behandling kan anvendes før eller efter indgiften af TMZ.
English: The resulting solution contains 2.5 mg/ml TMZ.
Danish: Den færdige opløsning indeholder 2,5 mg/ml TMZ.
English: Temodal is used for the treatment of specific forms of brain tumours: - in adults with newly-diagnosed glioblastoma multiforme.
Danish: Temodal anvendes til behandling af specifikke former for hjernesvulster: - hos voksne med nydiagnosticeret glioblastoma multiforme.
English: Adverse reactions in patients treated with temozolomide
Danish: Bivirkninger hos patienter behandlet med temozolomid
English:  10 and < 100 x 10
Danish:  10 og < 100 x 10
English: Signs of allergic reaction include feeling itchy, breathlessness or wheezing, swelling of the face, lips, tongue or throat.
Danish: Tegn på allergisk reaktion inkluderer: kløende fornemmelse, åndenød eller hvæsende åndedræt, hævelser i ansigtet, læber, tunge eller svælg.
English: Temodal 2.5 mg/ml is supplied as a pack of 1 vial.
Danish: Temodal 2,5 mg/ml leveres som pakker af 1 hætteglas.
English: • the same Grade 3 non-haematological toxicity (except for alopecia, nausea, vomiting) recurs after dose reduction.
Danish: • den samme Grad 3 ikke-hæmatologisk toksicitet (undtagen for alopeci, kvalme, opkastning) vender tilbage efter dosisreduktion.
English: Stomatitis, abdominal pain h, dyspepsia, dysphagia
Danish: Stomatitis, abdominalsmerter h, dyspepsi, dysfagi
English: Analysis of population-based pharmacokinetics of TMZ revealed that plasma TMZ clearance was independent of age, renal function or tobacco use.
Danish: Ved analyse af populationsbaseret farmakokinetik for TMZ blev det fundet, at plasma TMZ-clearance var uafhængig af alder, nyrefunktion og tobaksforbrug.
English: Temodal 2.5 mg/ml must be administered by intravenous infusion only over a period of 90 minutes.
Danish: Temodal 2,5 mg/ml skal kun indgives som intravenøs infusion over en periode på 90 min.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Danish: Overfølsomhed over for det aktive stof eller over for et eller flere af hjælpestofferne anført i pkt.6.1.
English: A variety of neoplasms, including mammary carcinomas, keratocanthoma of the skin and basal cell adenoma were observed in the 6-cycle rat study while no tumours or pre-neoplastic changes were evident in dog studies.
Danish: Forskellige neoplasier, omfattende brystcancer, keratoacanthom i huden og basalcelleadenom, fandtes i en undersøgelse omfattende 6-cycli på rotter, mens der ikke sås tumorer eller præneoplastiske forandringer i undersøgelser på hunde.
English: Your blood will be tested frequently during treatment to monitor the side effects of Temodal on your blood cells.
Danish: De vil regelmæssigt få undersøgt Deres blod under behandlingen for at følge Temodals bivirkninger på Deres blodceller.
English: Temodal hard capsules should be administered in the fasting state.
Danish: Temodal hårde kapsler bør indtages fastende.
English: It is incompatible with dextrose solutions.
Danish: Det er imkompatibelt med glucoseopløsninger.
English: The vials should be gently swirled and not shaken.
Danish: Hætteglasset bør hvirvles forsigtigt og må ikke rystes.
English: Very Common side effects (may affect more than 1 in 10 people) are: - loss of appetite, difficulty speaking, headache - vomiting, nausea, diarrhoea, constipation - rash, hair loss - tiredness
Danish: Meget almindelige bivirkninger (kan påvirke flere end 1 ud af 10 personer): - appetitløshed, talebesvær, hovedpine - opkastning, kvalme, diarré, forstoppelse - udslæt, hårtab - træthed.
English: If Temodal 2.5 mg/ml comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Danish: Hvis Temodal 2,5 mg/ml kommer i kontakt med hud eller slimhinder bør området straks vaskes omhyggeligt med sæbe og vand.
English: †, herpes simplex, infection reactivation, wound infection, gastroenteritis Neoplasm benign, malignant, and unspecified Uncommon:
Danish: †, herpes simplex, reaktivering af infektion, sårinfektion, gastroenteritis Benigne, maligne og uspecificerede tumorer Ikke almindelig:
English: Effective contraceptive precautions must be taken by both male and female patients who are using Temodal (see also “Male fertility” below).
Danish: Både mandlige og kvindelige patienter skal anvende sikre præventionsmidler, mens de bruger Temodal (se også ”Frugtbarhed hos mænd” nedenfor).
English: In vivo, the t1/2 of MTIC was similar to that of TMZ, 1.8 hr.
Danish: In vivo var t1/2 for MTIC 1,8 timer som for TMZ.
English: Do not use this medicine after the expiry date which is stated on the label and carton.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på etiketten og kartonen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: In patients 3 years of age or older, TMZ is only to be used in recurrent or progressive malignant glioma.
Danish: Hos patienter fra 3 år bør TMZ kun bruges ved recidiverende eller progressivt malignt gliom.
English: In a separate pharmacokinetic study, plasma pharmacokinetic profiles in patients with mild to moderate hepatic impairment were similar to those observed in patients with normal hepatic function.
Danish: I en separat farmakokinetikundersøgelse var plasmafarmakokinetikprofilen hos patienter med let til moderat leverinsufficiens sammenlignelig med profilen for patienter med normal leverfunktion.
English: See package leaflet for further information.
Danish: Se indlægssedlen for mere information.
English:  0.5 and < 1.5 x 10
Danish:  0,5 og < 1,5 x 10
English: Pneumocystis jirovecii pneumonia
Danish: Pneumocystis jirovecii-lungebetændelse
English: In a study of 288 subjects with newlydiagnosed glioblastoma multiforme, Grade 4 neutropenia occurred in 3 % of female vs 0 % of male subjects and Grade 4 thrombocytopenia in 1 % of female vs 0 % of male subjects in the first cycle of therapy.
Danish: I en undersøgelse med 288 forsøgspersoner med nyligt diagnosticeret multiform glioblastom forekom Grad 4-neutropeni hos 3 % af de kvindelige vs. 0 % af de mandlige forsøgspersoner og Grad 4-thrombocytopeni hos 1 % af de kvindelige vs. 0 % af de mandlige forsøgspersoner i det første terapiforløb.
English: It is recommended to seek advice on conservation of sperm prior to treatment.
Danish: Det anbefales at søge råd med hensyn til nedfrysningaf sædvæske før behandling.
English: The powder for solution for infusion is a white powder.
Danish: Pulver til infusionsvæske, opløsning er et hvidt pulver.
English: Pneumocystis jirovecii pneumonia (PCP) prophylaxis was required during RT and combined TMZ therapy.
Danish: Pneumocystis jirovecii pneumoni (PCP) forebyggende behandling var påkrævet under strålebehandling og konkomitant TMZ behandling.
English: Frequency groupings are defined according to the following convention: Very common (≥ 1/10); Common (≥ 1/100 to < 1/10); Uncommon (≥ 1/1,000 to < 1/100); Rare (≥1/10,000 to <1/1,000); Very rare (<1/10,000); Not known (cannot be estimated from the available data).
Danish: Hyppigheden er defineret i henhold til følgende konvention: Meget almindelig (≥ 1/10); almindelig (≥ 1/100 til < 1/10); ikke almindelig (≥ 1/1.000 til < 1/100); sjælden (≥ 1/10.000 til < 1/1.000); meget sjælden (< 1/10.000); ikke kendt (kan ikke estimeres ud fra forhåndenværende data).
English: Pneumonia, dyspnoea, sinusitis, bronchitis, coughing, upper respiratory infection
Danish: Lungebetændelse, dyspnø, sinusitis, bronchitis, hoste, øvre luftvejsinfektion
English: In patients treated with TMZ in clinical trials, the most common adverse reactions were nausea, vomiting, constipation, anorexia, headache, fatigue, convulsions, and rash.
Danish: Hos patienter behandlet med TMZ i kliniske studier var de hyppigste bivirkninger: kvalme, opkastning, obstipation, anoreksi, hovedpine, træthed, kramper og udslæt.
English: Thus, prophylaxis against PCP is required for all patients receiving concomitant TMZ and RT for the 42-day regimen (with a maximum of 49 days) regardless of lymphocyte count.
Danish: Forebyggende behandling mod PCP er derfor påkrævet for alle patienter, der får konkomitant TMZ og strålebehandling i 42 dages regime (med højst 49 dage) uafhængigt af lymfocyttal.
English: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.
Danish: Hvis De er gravid eller ammer, har mistanke om, at De er gravid, eller planlægger at blive gravid, skal De spørge Deres læge eller apotekspersonalet til råds, før De bruger dette lægemiddel.
English: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, erythroderma, skin exfoliation, photosensitivity reaction, urticaria, exanthema, dermatitis, sweating increased, pigmentation abnormal
Danish: Toksisk epidermal nekrolyse, Stevens-Johnsons syndrom, angioødem, erythema multiforme, erythroderma, hudeksfoliering, lysoverfølsomhedsreaktion, urticaria, eksantem, dermatitis, øget svedtendens, unormal pigmentering
English: When laboratory abnormalities and adverse events were combined across concomitant and monotherapy treatment phases, Grade 3 or Grade 4 neutrophil abnormalities including neutropenic events were observed in 8 % of the patients.
Danish: Når unormale laboratorieværdier og bivirkninger blev slået sammen på tværs af konkomitante og monoterapi behandlingsfaser, blev Grad 3- eller Grad 4-neutrofilabnormaliteter inklusive neutropeni-bivirkninger set hos 8 % af patienterne.
English: †, hepatic injury, hepatitis, cholestasis, hyperbilirubinemia
Danish: †, leverskade, hepatitis, kolestase, hyperbilirubinæmi
English: Dose levels include 100 mg/m 2, 150 mg/m 2, and
Danish: Dosisniveauerne omfatter 100 mg/m 2, 150 mg/m 2 og 200 mg/m 2.
English: The cap is imprinted with “Temodal”.
Danish: Hætten bærer et tryk med ”Temodal”.
English: Clear type I glass vial sealed with bromobutyl rubber stopper and aluminium overseal with peach-coloured flip-off bonnet.
Danish: Klart hætteglas (type I glas) forseglet med bromobutyl gummiprop og aluminium oversegl med ferskenfarvet flipp-off hætte.
English: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Danish: Hvis De er gravid eller ammer, har mistanke om, at De er gravid, eller planlægger at blive gravid, skal De spørge Deres læge eller apotekspersonalet til råds, før De tager dette lægemiddel.
English: Radiation injury
Danish: Stråleskader
English: This medicine contains 2.4 mmol sodium per vial.
Danish: Dette lægemiddel indeholder 2,4 mmol natrium pr. hætteglas.
English: Effective contraceptive precautions must be taken by both male and female patients who are taking Temodal (see also “Male fertility” below).
Danish: Både mandlige og kvindelige patienter skal anvende sikre præventionsmidler, mens de tager Temodal (se også ”Frugtbarhed hos mænd” nedenfor).
English: The following information is intended for medical or health care professional use only:
Danish: Nedenstående oplysninger er til læger og sundhedspersonale
English: Your doctor will work out your dose of Temodal.
Danish: Deres læge vil fastsætte den rigtige dosis Temodal for Dem.
English: MTIC is spontaneously hydrolyzed to 5-aminoimidazole-4-carboxamide (AIC), a known intermediate in purine and nucleic acid biosynthesis, and to methylhydrazine, which is believed to be the active alkylating species.
Danish: MTIC hydrolyseres spontant til 5-amino-imidazol-4-carboxamid (AIC), et kendt mellemprodukt i purin- og nucleinsyrebiosyntesen, og til methylhydrazin, som menes at være det aktive alkylerende stof.
English: In addition to the side effects listed above, the following may also occur with the use of Temodal powder for solution for infusion: pain, irritation, itching, warmth, swelling or redness at the injection site; also bruising (haematoma).
Danish: Foruden de ovenstående bivirkninger kan følgende også forekomme ved brug af Temodal pulver til infusionsvæske, opløsning: smerter, irritation, kløe, varme, hævelse eller rødme på injektionsstedet; også blå mærker (hæmatoma).
English: †, interstitial pneumonitis/pneumonitis, pulmonary fibrosis, nasal congestion
Danish: †, interstitiel pneumonitis/pneumonitis, lungefibrose, næsetæthed
English: What Temodal contains
Danish: Temodal indeholder
English: If vomiting occurs after the dose is administered, a second dose should not be administered that day.
Danish: Hvis opkastning forekommer, efter dosis er indtaget, skal en anden dosis ikke indtages samme dag.
English: If you are a newly-diagnosed patient, treatment will occur in two phases: - treatment together with radiotherapy (concomitant phase) first - followed by treatment with only Temodal (monotherapy phase).
Danish: Hvis De er nydiagnosticeret patient, vil behandlingen ske i to faser: - behandling sammen med strålebehandling (konkomitant-fasen) først - efterfulgt af behandling kun med Temodal (monoterapi-fasen)
English: Temodal 2.5 mg/ml powder for solution for infusion delivers equivalent TMZ dose and exposure to both TMZ and its active metabolite MTIC as the corresponding Temodal hard capsules (see section 5.2).
Danish: Temodal 2,5 mg/ml pulver til infusionsvæske, opløsning, leverer TMZ doser samt udsættelse for både TMZ og den aktive metabolit MTIC ækvivalent med den tilsvarende Temodal hårde kapsel (se pkt.
English: The hard capsules for oral use are dispensed in amber glass bottles containing 5 or 20 capsules.
Danish: De hårde kapsler til oral brug udleveres i ravgule glasflasker, der indeholder 5 eller 20 kapsler.
English: Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
Danish: Læs denne indlægsseddel grundigt, inden De begynder at tage dette lægemiddel, da den indeholder vigtige oplysninger - Gem indlægssedlen.
English: Temodal is indicated for the treatment of: - adult patients with newly-diagnosed glioblastoma multiforme concomitantly with radiotherapy (RT) and subsequently as monotherapy treatment.
Danish: Temodal er indiceret til behandling af: - voksne patienter med nydiagnosticeret glioblastoma multiforme konkomitant med strålebehandling og herefter som monoterapi-behandling.
English: If you take more Temodal than you should If you accidentally take more Temodal capsules than you were told to, contact your doctor, pharmacist or nurse immediately.
Danish: Hvis De ved en fejl tager flere Temodal-kapsler end foreskrevet, skal De straks kontakte Deres læge, apotekspersonalet eller sygeplejersken.
English: Ataxia, balance impaired, cognition impaired, concentration impaired, consciousness decreased, dizziness, hypoesthesia, memory impaired, neurologic disorder, neuropathy d, paraesthesia, somnolence, speech disorder, taste perversion, tremor
Danish: Ataksi, nedsat balanceevne, nedsat kognitiv funktionsevne, nedsat koncentrationsevne, bevidsthedssvækkelse, svimmelhed, hypoæstesi, nedsat hukommelse, neurologisk lidelse, neuropati d, paræstesi, søvnighed, taleforstyrrelse, smagsforstyrrelse, tremor
English: TMZ is spontaneously hydrolyzed at physiologic pH primarily to the active species, 3-methyl(triazen-1-yl)imidazole-4-carboxamide (MTIC).
Danish: TMZ hydrolyseres spontant ved fysiologisk pH primært til det aktive stof, 3-methyl-(triazen-1yl)imidazol-4-carboxamid (MTIC).
English: In the non-comparative trial, the PFS at 6 months was 19 %, the median progression-free survival was 2.1 months, and the median overall survival 5.4 months.
Danish: I den ikke-randomiserede undersøgelse var PFS efter 6 måneder 19 %, median progressiv overlevelse var 2,1 måneder, og median samlet overlevelse 5,4 måneder.
English: Other medicines and Temodal
Danish: Brug af anden medicin sammen med Temodal
English: The cytotoxicity of MTIC is thought to be due primarily to alkylation at the O
Danish: MTIC's cytotoksiske effekt formodes primært at skyldes alkyleringen ved O
English: 9/l or the platelet count is < 50 x 10
Danish: 9/l, eller trombocyttallet er < 50 x 10
English: In some cases, it may be prolonged and may lead to a very severe form of anaemia (aplastic anaemia).
Danish: Dette fald i antallet af blodceller er oftest forbigående, men i nogle tilfælde kan det være længerevarende og medføre en meget alvorlig form for anæmi (aplastisk anæmi).
English: capsule shell:
Danish: kapselskal:
English: Temodal contains lactose
Danish: Temodal indeholder lactose
English: 9/l; thrombocyte count  100 x 10
Danish: 9/l; trombocyttal  100 x 10
English: Figure 1 Kaplan-Meier curves for overall survival (Intent to treat population)
Danish: Figur 1 Kaplan-Meier kurver for total overlevelse (ITT population)
English: This was followed by monotherapy TMZ (150 - 200 mg/m2) on Days 1 - 5 of every 28-day cycle for up to 6 cycles, starting 4 weeks after the end of RT.
Danish: Dette blev efterfulgt af monoterapi med TMZ (150 - 200 mg/m2) på dag 1 - 5 i hver 28-dags-serie i op til 6 serier, startende 4 uger efter afsluttet strålebehandling.
English: TMZ dose reduction or discontinuation during monotherapy treatment Toxicity
Danish: TMZ dosisreduktion eller seponering under monoterapi-behandling Toksicitet
English: Temodal is first used together with radiotherapy (concomitant phase of treatment) and after that alone (monotherapy phase of treatment).
Danish: Temodal bruges først sammen med strålebehandling (konkomitant fase af behandlingen) og efterfølgende alene (monoterapibehandling).
English: For sodium, see leaflet for further information.
Danish: Se indlægssedlen for mere information omkring natrium.
English: TMZ dosing interruption or discontinuation during concomitant radiotherapy and TMZ
Danish: TMZ-doseringsafbrydelse eller seponering under konkomitant strålebehandling og TMZ
English: In an open-label, two-way crossover bioequivalence study of the pharmacokinetics of oral and intravenous TMZ in patients with primary CNS malignancies, Temodal 2.5 mg/ml powder for solution for infusion administered over 90 minutes was found to be bioequivalent for Cmax and AUC
Danish: I et åbent-label, two-way crossover bioækvivalensstudie af farmakokinetikken for oral og intravenøs TMZ hos patienter med primært CNS maligniciteter, blev Temodal 2,5 mg/ml pulver til infusionsvæske, opløsning, indgivet over 90 min fundet til at være bioækvivalent mht. Cmax og AUC for TMZ og MTIC sammenlignet med Temodal hårde kapsler efterfulgt af en indgift på 150 mg/m Gennemsnits Cmax-værdier for TMZ og MTIC var henholdsvis 7,4 µg/ml og 320 ng/ml efter 90 min intravenøs infusion.
English: Temodal will be given to you by your doctor in a drip into a vein (intravenous infusion), only over approximately 90 minutes.
Danish: Temodal indgives af Deres læge dråbevis i en vene (intravenøs infusion) i løbet af kun ca. 90 min. Andre infusionssteder end en vene er ikke acceptable.
English: Temodal 2.5 mg/ml powder for solution for infusion, given as an intravenous infusion over 90 minutes, is bioequivalent to the hard capsule formulation (see section 5.2).
Danish: Temodal 2,5 mg/ml pulver til infusionsvæske, opløsning, givet som en intravenøs infusion over 90 min er bioækvivalent med den hårde kapselformulering (se pkt.
English: Contact your doctor immediately if you have any of the following: - a severe allergic (hypersensitive) reaction (hives, wheezing or other breathing difficulty), - uncontrolled bleeding, - seizures (convulsions), - fever, - chills, - severe headache that does not go away.
Danish: Kontakt øjeblikkeligt Deres læge, hvis De oplever noget af følgende: - en kraftig allergisk (overfølsomheds) reaktion (kløende udslæt, hvæsende vejrtrækning eller anden form for åndedrætsbesvær), - ukontrolleret blødning, - anfald (kramper), - feber, - kulderystelser, - kraftig hovedpine, som ikke går væk.
English: Adverse reactions in patients treated with temozolomide Reproductive system and breast disorders Uncommon:
Danish: Bivirkninger hos patienter behandlet med temozolomid Det reproduktive system og mammae Ikke almindelig: