FrancophonIA/ELRC3.0 huggingface dataset:
English: Elderly: A modest increase in AUC (28 %) and C24h (32 %) was observed in elderly male subjects compared with young male subjects.
Slovenian: Starejši bolniki: Pri starejših moških preiskovancih so ugotovili zmerno povečanje AUC (28 %) in C24h (32 %) v primerjavi z mladimi moškimi.
English: Aspergillus flavus [N = 111], Aspergillus niger [N = 31], Aspergillus nidulans [N = 8], Aspergillus terreus [N = 52], and Aspergillus candidus [N = 3]).
Slovenian: In vitro je kaspofungin učinkovit proti Aspergillus sp. (Aspergillus fumigatus n = 75, Aspergillus flavus n = 111, Aspergillus niger n = 31, Aspergillus nidulans n = 8, Aspergillus terreus n = 52
English: Other local reactions included erythema, pain/tenderness, itching, discharge, and a burning sensation.
Slovenian: Druge lokalne reakcije so vključevale eritem, bolečino/občutljivost, srbenje, izcedek in pekoč občutek.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Intravenous use after reconstitution and dilution.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Intravenska uporaba po predhodni pripravi in razredčenju.
English: If the drug was well tolerated but the patient's fever persisted and clinical condition deteriorated after 5 days of therapy, the dosage of study drug could be increased to 70 mg/day of caspofungin (13.3 % of patients treated) or to 5.0 mg/kg/day of liposomal amphotericin B (14.3 % of patients treated).
Slovenian: Če je bolnik zdravilo dobro prenašal, a je imel po 5 dneh zdravljenja še vedno zvišano telesno temperaturo, klinično stanje pa se je slabšalo, je bilo mogoče odmerek študijskega zdravila zvečati na 70 mg kaspofungina/dan (13,3 % zdravljenih bolnikov) oz. na 5,0 mg liposomskega amfotericina B/kg/dan (14,3 % zdravljenih bolnikov).
English: • Sensation of fast or irregular heart beats, rapid heart beat, irregular heart beat, abnormal heart rhythm, heart failure
Slovenian: • občutek hitrega ali nepravilnega utripanja srca, pospešen srčni utrip, nepravilen srčni utrip, nenormalni srčni ritem, srčno popuščanje
English: Although the doses of prior antifungal therapies in 5 patients enrolled as refractory were lower than those often administered for invasive aspergillosis, the favourable response rate during therapy with caspofungin was similar in these patients to that seen in the remaining refractory patients (2/5 versus 17/48, respectively).
Slovenian: Čeprav so bili pri 5 bolnikih, ki so bili v študijo vključeni kot nedovzetni, odmerki prejšnjih protiglivnih zdravil manjši, kot se običajno uporabljajo pri invazivni aspergilozi, je bil delež ugodnega odziva na zdravljenje s kaspofunginom pri njih (2/5) podoben deležu pri ostalih neodzivnih bolnikih (17/48).
English: In lieu of breakpoints, Candida isolates that are susceptible to anidulafungin as well as micafungin should be considered susceptible to caspofungin.
Slovenian: Namesto mejnih vrednosti je treba upoštevati, da so izolati vrste Candida, ki so občutljivi za anidulafungin kot tudi za mikafungin, občutljivi za kaspofungin.
English: What Caspofungin Accord is and what it is used for What you need to know before you are given Caspofungin Accord How to use Caspofungin Accord
Slovenian: Kaj je zdravilo Kaspofungin Accord in za kaj ga uporabljamo Kaj morate vedeti, preden boste dobili zdravilo Kaspofungin Accord Kako uporabljati zdravilo Kaspofungin Accord Možni neželeni učinki
English: Do not use if the solution is cloudy or has precipitated.
Slovenian: Raztopine ne uporabite, če je motna ali če se je pojavila oborina.
English: Limited data from population pharmacokinetics studies indicate that concomitant use of caspofungin with the inducers efavirenz, nevirapine, rifampicin, dexamethasone, phenytoin, or carbamazepine may result in a decrease in caspofungin AUC.
Slovenian: Malo podatkov iz populacijskih farmakokinetičnih študij kaže, da lahko sočasna uporaba kaspofungina z induktorji efavirenzom, nevirapinom, rifampicinom, deksametazonom, fenitoinom ali karbamazepinom povzroči zmanjšanje AUC kaspofungina.
English: Some healthy adult volunteers who received two 3 mg/kg doses of cyclosporin with caspofungin showed transient increases in alanine transaminase (ALT) and aspartate transaminase (AST) of less than or equal to 3-fold the upper limit of normal (ULN) that resolved with discontinuation of the treatment.
Slovenian: Pri nekaterih zdravih odraslih prostovoljcih, ki so sočasno dobili dva odmerka ciklosporina 3 mg/kg ter kaspofungin, je prišlo do prehodnega povečanja alanin transaminaze (ALT) in aspartat transaminaze (AST), ki je bilo manjše ali enako 3-kratni zgornji meji normalne vrednosti in ki se je normaliziralo po prekinitvi zdravljenja.
English: Possibly histamine-mediated adverse reactions, including rash, facial swelling, angioedema, pruritus, sensation of warmth, or bronchospasm have been reported and may require discontinuation and/or administration of appropriate treatment.
Slovenian: Poročali so o verjetno histaminsko posredovanih neželenih učinkih, ki so vključevali izpuščaj, otekanje obraza, angioedem, pruritus, občutek toplote ali bronhospazem in ki lahko zahtevajo ukinitev kaspofungina in/ali ustrezno zdravljenje.
English: If any of the above applies to you (or you are not sure), talk to your doctor, nurse or pharmacist before you are given Caspofungin Accord.
Slovenian: Če kaj od zgoraj naštetega velja za vas (ali pa niste prepričani), se pogovorite z zdravnikom, medicinsko sestro ali farmacevtom, preden dobite zdravilo Kaspofungin Accord.
English: If you have any further questions on the use of this medicine, ask your doctor, nurse or pharmacist.
Slovenian: Če imate dodatna vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom, medicinsko sestro ali farmacevtom.
English: There is no clinical experience in adult patients with severe hepatic impairment (Child-Pugh score greater than 9) and in paediatric patients with any degree of hepatic impairment (see section 4.4).
Slovenian: Kliničnih izkušenj pri odraslih bolnikih s hudo jetrno okvaro (stopnja Child-Pugh nad 9 točk) in pri pediatričnih bolnikih s katero koli stopnjo jetrne okvare nimamo (glejte poglavje 4.4).
English: Data from 5 clinical studies completed in 171 paediatric patients suggest that the overall incidence of clinical adverse experiences (26.3%; 95% CI -19.9, 33.6) is not worse than reported for adults treated with caspofungin (43.1%; 95% CI -40.0, 46.2).
Slovenian: Podatki iz 5 kliničnih študij pri 171 pediatričnih bolnikih kažejo, da skupna pojavnost kliničnih neželenih učinkov (26,3 %; 95 % IZ -19,9; 33,6) ni večja kot pri odraslih, zdravljenih s kaspofunginom (43,1 %; 95 % IZ -40,0; 46,2).
English: 564 febrile neutropaenic patients (empirical therapy study), 382 patients with invasive candidiasis, 228 patients with invasive aspergillosis, 297 patients with localised Candida infections, and 394 individuals enrolled in Phase I studies.
Slovenian: V kliničnih študijah je 1.865 odraslih oseb dobilo enkratne ali večkratne odmerke kaspofungina: 564 bolnikov s febrilno nevtropenijo (študija empiričnega zdravljenja), 382 bolnikov z invazivno kandidiazo, 228 bolnikov z invazivno aspergilozo, 297 bolnikov z lokaliziranimi okužbami s Candido in 394 oseb vključenih v študije I. faze.
English: Caspofungin did not influence the pharmacokinetics of amphotericin B, itraconazole, rifampicin or mycophenolate mofetil.
Slovenian: Kaspofungin ni vplival na farmakokinetiko amfotericina B, itrakonazola, rifampicina ali mofetilmikofenolata.
English: Most patients had underlying conditions (haematologic malignancy [N = 24], allogeneic bone marrow transplant or stem cell transplant [N = 18], organ transplant [N = 8], solid tumour [N = 3], or other conditions [N = 10]).
Slovenian: Večina bolnikov je imela neko osnovno bolezen/stanje (maligno hematološko bolezen n = 24, stanje po alogenski presaditvi kostnega mozga ali matičnih celic n = 18, stanje po presaditvi organa n = 8, solidni tumor n = 3 ali drugo bolezen/stanje n = 10).
English: However, caspofungin has been shown to interact with other medicinal products in pharmacological and clinical studies (see below).
Slovenian: Vendar pa so se v farmakoloških in kliničnih študijah pokazale interakcije kaspofungina z drugimi zdravili (glejte nadaljevanje).
English: How to store Caspofungin Accord Contents of the pack and other information
Slovenian: Shranjevanje zdravila Kaspofungin Accord Vsebina pakiranja in dodatne informacije
English: Susceptibility testing was performed according to a modification of both the Clinical and Laboratory Standards Institute (CLSI, formerly known as the National Committee for Clinical Laboratory Standards [NCCLS]) method M38-A2 (for Aspergillus species) and method M27-A3 (for Candida species).
Slovenian: Testiranje občutljivosti je bilo izvedeno po modifikaciji metode M38-A2 (za Aspergillus sp.) kot tudi metode M27-A3 (za Candida sp.) Inštituta za klinične in laboratorijske standarde (CLSI, prej znanega pod imenom Nacionalni odbor za klinične laboratorijske standarde [National Committee for Clinical Laboratory Standard - NCCLS]).
English: Developmental toxicity studies in rats showed that caspofungin caused decreases in foetal body weights and an increase in the incidence of incomplete ossification of vertebra, sternebra, and skull bone at doses of 5 mg/kg that were coupled to adverse maternal effects such as signs of histamine release in pregnant rats.
Slovenian: Študije toksičnega vpliva na razvoj pri podganah so pokazale, da kaspofungin povzroči zmanjšanje telesne mase ploda in povečanje pojavnosti nepopolnega zakostenevanja vretenc, prsnice in lobanjskih kosti pri odmerkih 5 mg/kg, kar je povezano z neželenimi učinki pri materi, kot so znaki sproščanja histamina pri brejih podganah.
English: Caspofungin Accord makes fungal cells fragile and stops the fungus from growing properly.
Slovenian: Zdravilo Kaspofungin Accord povzroča krhkost glivnih celic in ustavi pravilno rast gliv.
English: • rash, itching, feeling warm, swelling of your face, lips or throat or difficulty breathing - you may be having a histamine reaction to the medicine.
Slovenian: • izpuščaj, srbenje, občutek vročine, otekanje obraza, ustnic ali žrela ali težave pri dihanju morda imate histaminsko reakcijo na zdravilo,
English: Caspofungin is not dialysable, thus supplementary dosing is not required following haemodialysis.
Slovenian: Kaspofungin se ne dializira, zato po hemodializi ni potreben nadomestni odmerek.
English: An overall favourable response required meeting each of 5 criteria: (1) successful treatment of any baseline fungal infection (caspofungin 51.9 % [14/27], liposomal amphotericin B 25.9 % [7/27]), (2) no breakthrough fungal infections during administration of study drug or within 7 days after completion of treatment (caspofungin 94.8 % [527/556], liposomal amphotericin B 95.5 % [515/539]), (3) survival for 7 days after completion of study therapy (caspofungin 92.6 % [515/556], liposomal amphotericin B 89.2 % [481/539]), (4) no discontinuation from the study drug because of drug-related toxicity or lack of efficacy (caspofungin 89.7 % [499/556], liposomal amphotericin B 85.5 % [461/539]), and (5) resolution of fever during the period of neutropaenia (caspofungin 41.2 % [229/556], liposomal amphotericin B 41.4 % [223/539]).
Slovenian: Celotni odziv je bil ocenjen kot ugoden, če je bilo izpolnjenih vseh 5 naslednjih meril: (1) uspešno zdravljenje katerekoli osnovne glivne okužbe (kaspofungin 51,9 % [14/27], liposomski amfotericin B 25,9 % [7/27]), (2) brez izbruha glivnih okužb med uporabo študijskega zdravila in 7 dni po zaključku zdravljenja (kaspofungin 94,8 % [527/556], liposomski amfotericin B 95,5 % [515/539]), (3) preživetje 7 dni po zaključku raziskovane terapije (kaspofungin 92,6 % [515/556], liposomski amfotericin B 89,2 % [481/539]), (4) brez prekinitve raziskovanega zdravila zaradi z njim povezane toksičnosti ali nezadostne učinkovitosti (kaspofungin 89,7 % [499/556], liposomski amfotericin B 85,5 % [461/539]), (5) izginotje zvišane telesne temperature med obdobjem nevtropenije (kaspofungin 41,2 % [229/556], liposomski amfotericin B 41,4 % [223/539]).
English: This infusion solution must be used within 24 hours if stored at or below 25°C or within 48 hours if stored refrigerated at 2 to 8°C.
Slovenian: Raztopino za infundiranje je treba uporabiti v 24 urah, če je shranjena pri temperaturi 25 °C ali manj, ali v 48 urah, če je shranjena na hladnem pri temperaturi od 2 do 8 °C.
English: • Abnormal skin tissue, generalised itching, hives, rash of varying appearance, abnormal skin, red often itchy spots on your arms and legs and sometimes on the face and the rest of the body
Slovenian: • nenormalno kožno tkivo, srbenje po celem telesu, koprivnica, različni izpuščaji, nenormalna koža, rdeče in pogosto srbeče lise na okončinah ter včasih na obrazu in ostalem delu telesa
English: Paediatric Patients
Slovenian: Pediatrični bolniki
English: Moderate (creatinine clearance 31 to 49 mL/min), advanced (creatinine clearance 5 to 30 mL/min), and end-stage (creatinine clearance <10 mL/min and dialysis dependent) renal impairment moderately increased caspofungin plasma concentrations after single-dose administration (range: 30 to 49 % for AUC).
Slovenian: Zaradi zmerne okvare (kreatininski očistek 31 do 49 ml/min), napredovale okvare (kreatininski očistek 5 do 30 ml/min) in končne ledvične odpovedi (kreatininski očistek < 10 ml/min in na dializi) se je plazemska koncentracija kaspofungina po enem odmerku zmerno povečala (razpon: za 30 do 49 % AUC).
English: No dosage adjustment is necessary based on renal impairment (see section 5.2).
Slovenian: Prilagoditev odmerka glede na ledvično okvaro ni potrebna (glejte poglavje 5.2).
English: For adult patients with moderate hepatic impairment (Child-Pugh score 7 to 9), Caspofungin 35 mg daily is recommended based upon pharmacokinetic data.
Slovenian: Pri odraslih bolnikih z zmerno jetrno okvaro (stopnja Child-Pugh 7 do 9 točk) glede na farmakokinetične podatke priporočamo kaspofungin v odmerku 35 mg dnevno.
English: The favourable response rate, by indication, at the end of caspofungin therapy was as follows in the MITT analysis: 81 % (30/37) in invasive candidiasis, 50 % (5/10) in invasive aspergillosis, and 100 % (1/1) in esophageal candidiasis.
Slovenian: Deleži ugodnega odziva za posamezno indikacijo so bili na koncu zdravljenja s kaspofunginom v analizi MITT naslednji: 81 % (30/37) pri invazivni kandidiazi, 50 % (5/10) pri invazivni aspergilozi in 100 % (1/1) pri ezofagealni kandidiazi.
English: In limited clinical experience, resistance to caspofungin in patients with invasive aspergillosis has been observed.
Slovenian: V omejenih kliničnih izkušnjah so pri bolnikih z invazivno aspergilozo opazili rezistenco na kaspofungin.
English: Other medicines and Caspofungin Accord
Slovenian: Druga zdravila in zdravilo Kaspofungin Accord
English: Race: Patient pharmacokinetic data indicated that no clinically significant differences in the pharmacokinetics of caspofungin were seen among Caucasians, Blacks, Hispanics, and Mestizos.
Slovenian: Rasa: Farmakokinetični podatki pri bolnikih so pokazali, da ni bilo klinično pomembnih razlik v farmakokinetiki kaspofungina pri belcih, črncih, Latinoameričanih ter mešancih belih in indijanskih staršev.
English: Distribution plays the prominent role in caspofungin plasma pharmacokinetics and is the rate-controlling step in both the alpha- and beta-disposition phases.
Slovenian: Porazdelitev ima pomembno vlogo v plazemski farmakokinetiki kaspofungina in določa hitrost obeh - faze alfa in faze beta razporeditve.
English: If you are not sure, talk to your doctor, nurse or pharmacist before you are given your medicine.
Slovenian: Če ste negotovi, se posvetujte z zdravnikom, medicinsko sestro ali farmacevtom, preden začnete uporabljati vaše zdravilo.
English: • Fast heart beat
Slovenian: • hiter srčni utrip
English: Rifampicin caused a 60 % increase in AUC and 170 % increase in trough concentration of caspofungin on the first day of co-administration when both medicinal products were initiated together in healthy adult volunteers.
Slovenian: Rifampicin je pri zdravih odraslih prostovoljcih prvi dan sočasnega zdravljenja s kaspofunginom povzročil 60 % povečanje AUC kaspofungina in 170 % zvečanje koncentracije kaspofungina, izmerjene tik pred naslednjim odmerkom, če je bilo zdravljenje z obema zdraviloma uvedeno hkrati.
English: The maximum loading dose on Day 1 should not exceed 70 mg regardless of the patient's calculated dose.
Slovenian: Največji uvajalni odmerek 1. dan ne sme preseči 70 mg, ne glede na izračunani odmerek za bolnika.
English: DO NOT MIX OR CO-INFUSE CASPOFUNGIN ACCORD WITH ANY OTHER MEDICINES, as there are no data available on the compatibility of Caspofungin Accord with other intravenous substances, additives, or medicinal products.
Slovenian: ZDRAVILA KASPOFUNGIN ACCORD NE MEŠAJTE IN NE INFUNDIRAJTE SKUPAJ S KATERIMKOLI DRUGIM ZDRAVILOM, ker ni podatkov o kompatibilnosti zdravila Kaspofungin Accord in drugih substanc, aditivov in zdravil za intravensko uporabo.
English: Fungicidal activity with caspofungin has been demonstrated against Candida yeasts.
Slovenian: Fungicidno delovanje kaspofungina je bilo dokazano proti kvasovkam vrste Candida.
English: Caspofungin is not dialysable.
Slovenian: Kaspofungin se ne dializira.
English: Two intermediate products, formed during the degradation of caspofungin to this open ring compound, form covalent adducts to plasma proteins resulting in a low-level, irreversible binding to plasma proteins.
Slovenian: Dva vmesna presnovka, ki nastaneta tekom razgradnje v spojino z odprtim obročem, tvorita kovalentne adukte s plazemskimi proteini, ki predstavljajo majhen delež ireverzibilne povezave s plazemskimi proteini.
English: Phlebitis was a commonly reported local injection-site adverse reaction in all patient populations.
Slovenian: Flebitis je bil pogost neželeni učinek na mestu vboda pri vseh populacijah bolnikov.
English: Stability data have shown that the concentrate for solution for infusion can be stored for up to 24 hours when the vial is stored at 25°C or less and reconstituted with water for injections.
Slovenian: Stabilnostni podatki kažejo, da koncentrat za pripravo raztopine za infundiranje, ki smo ga pripravili z vodo za injekcije, lahko shranjujemo do 24 ur pri temperaturi 25 °C ali manj.
English: The favourable response rates for patients who were either refractory to or intolerant of previous therapies were 36 % (19/53) and 70 % (7/10), respectively.
Slovenian: Delež ugodnega odziva je pri bolnikih, ki se na prejšnje zdravljenje niso odzvali, znašal 36 % (19/53), med bolniki, ki prejšnjega zdravljenja niso prenašali, pa 70 % (7/10).
English: Investigations decreased potassium, hypomagnesemia, increased glucose, decreased phosphorus, and increased phosphorus
Slovenian: Preiskave znižane vrednosti kalija, hipomagneziemija, zvišane vrednosti glukoze, znižane vrednosti fosforja in zvišane vrednosti fosforja
English: Standard preparation (reconstituted Caspofungin Accord added to 250 mL) final concentration
Slovenian: Standardna priprava (koncentrat zdravila Kaspofungin Accord dodan v 250 ml) končna koncentracija
English: • Changes in some laboratory blood tests (including increased values of some liver tests)
Slovenian: • spremembe nekaterih laboratorijskih izvidov krvi (vključno s povečanimi vrednostmi nekaterih jetrnih testov)
English: • Flushing, hot flush, high blood pressure, low blood pressure, redness along a vein which is extremely tender when touched
Slovenian: • zardevanje, naval vročine, visok krvni tlak, nizek krvni tlak, rdečina na mestu ob veni, ki je izredno občutljivo na dotik
English: Caspofungin 50 mg once daily was administered following a 70 mg loading dose, while amphotericin B was administered at 0.6 to 0.7 mg/kg/day to non-neutropaenic patients or 0.7 to 1.0 mg/kg/day to neutropaenic patients.
Slovenian: Kaspofungin so po 70 mg uvajalnem odmerku uporabljali v odmerku 50 mg enkrat na dan. Amfotericin B so pri nenevtropeničnih bolnikih uporabljali v odmerku 0,6 do 0,7 mg/kg/dan, pri nevtropeničnih pa v odmerku 0,7 do 1,0 mg/kg/dan.
English: • Women given Caspofungin Accord should not breast-feed.
Slovenian: • Ženske, ki uporabljajo zdravilo Kaspofungin Accord, ne smejo dojiti.
English: Of note, the efficacy and safety of caspofungin have not been adequately studied in prospective clinical trials involving neonates and infants under 3 months of age.
Slovenian: Opozoriti je treba, da učinkovitost in varnost kaspofungina nista bili dovolj raziskani v prospektivnih kliničnih preskušanjih pri novorojenčkih in dojenčkih, mlajših od 3 mesecev.
English: Therapy should be continued until up to 72 hours after resolution of neutropaenia (ANC≥500).
Slovenian: Zdravljenje se mora nadaljevati še 72 ur po tem, ko nevtropenija izgine (absolutno število nevtrofilcev ≥ 500).
English: What Caspofungin Accord looks like and contents of the pack Caspofungin Accord powder for concentrate for solution for infusion is a white to off-white powder.
Slovenian: Izgled zdravila Kaspofungin Accord in vsebina pakiranja Kaspofungin Accord prašek za koncentrat za raztopino za infundiranje je bel do skoraj bel prašek.
English: Aseptically add 10.5 mL of water for injection.a This reconstituted solution may be stored for up to 24 hours at or below 25°C.b This will give a final caspofungin concentration in the vial of
Slovenian: Aseptično dodajte 10,5 ml vode za injekcije.a Pripravljeno raztopino lahko shranite za največ 24 ur pri temperaturi 25 °C ali manj.b Končna koncentracija kaspofungina v viali bo tako
English: You will be given Caspofungin Accord:
Slovenian: Zdravilo Kaspofungin Accord boste prejeli:
English: Invasive Candidiasis in Adult Patients: Two hundred thirty-nine patients were enrolled in an initial study to compare caspofungin and amphotericin B for the treatment of invasive candidiasis.
Slovenian: Invazivna kandidiaza pri odraslih bolnikih: V prvotno študijo, ki je primerjala kaspofungin in amfotericin B pri zdravljenju invazivne kandidiaze, je bilo vključenih 239 bolnikov.
English: The overall success rates in the MITT analysis results, adjusted by risk strata, were as follows: 46.6 % (26/56) for caspofungin and 32.2 % (8/25) for liposomal amphotericin B.
Slovenian: analize, prilagojenih glede na stratume tveganja, sta bila: 46,6 % (26/56) za kaspofungin in 32,2 % (8/25) za liposomski amfotericin B.
English: For caspofungin, there were no effects on fertility in studies conducted in male and female rats (see section 5.3).
Slovenian: V študijah, izvedenih na samcih in samicah podgan, kaspofungin ni imel učinkov na plodnost (glejte poglavje 5.3).
English: BSA (m2) X 70 mg/m2 = Loading Dose
Slovenian: Telesna površina (m2) X 70 mg/m2 = uvajalni odmerek
English: Your doctor will determine the duration of your treatment and how much Caspofungin Accord you will be given each day.
Slovenian: Zdravnik bo določil trajanje zdravljenja in dnevni odmerek zdravila Kaspofungin Accord.
English: In a retrospective study of 40 patients treated during marketed use with caspofungin and cyclosporin for 1 to 290 days (median 17.5 days), no serious hepatic adverse reactions were noted.
Slovenian: V retrospektivni študiji pri 40 bolnikih, ki so med trženjem zdravila dobivali kaspofungin in ciklosporin 1 do 290 dni (mediana 17,5 dni), niso opazili resnih neželenih učinkov na jetra.
English: Cardiac disorders tachycardia
Slovenian: Srčne bolezni tahikardija
English: When caspofungin is co-administered to paediatric patients (12 months to 17 years of age) with inducers of drug clearance, such as rifampicin, efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine, a caspofungin dose of 70-mg/m2 daily (not to exceed an actual daily dose of 70 mg) should be considered.
Slovenian: Če se kaspofungin uporablja pri pediatričnih bolnikih (starih od 12 mesecev do 17 let) sočasno z induktorji očistka zdravila, kakršni so rifampicin, efavirenz, nevirapin, fenitoin, deksametazon ali karbamazepin, je treba razmisliti o uporabi kaspofungina v odmerku 70 mg/m2 na dan (pri čemer pa absolutni dnevni odmerek ne sme preseči 70 mg).