FrancophonIA/ELRC3.0 huggingface dataset:
English: Posaconazole SP must not be administered with medicinal products that are substrates for CYP3A4 and are known to prolong the QTc interval (see sections 4.3 and 4.5).
Danish: Posaconazole SP må ikke administreres sammen med lægemidler, som er substrater for CYP3A4, og som er kendt for at forlænge QTc-intervallet (se pkt.
English: INFORMATION IN BRAILLE Posaconazole SP
Danish: INFORMATION I BRAILLE-SKRIFT Posaconazole SP
English: The effect of other H2 receptor antagonists (e.g. famotidine, ranitidine) and proton pump inhibitors (e.g. omeprazole) that may suppress gastric acidity for several hours on plasma levels of posaconazole has not been studied but a reduction in bioavailability may occur so that coadministration should be avoided if possible.
Danish: Det er ikke undersøgt om andre H2-receptor antagonister (f.eks. famotidin, ranitidin) og protonpumpehæmmere (f.eks. omeprazol), som undertrykker mavesyreproduktionen i flere timer, indvirker på plasmakoncentrationen af posaconazol, men en reduktion af biotilgængeligheden kan forekomme, så samtidig administration bør om muligt undgås.
English: Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine since this may result in increased plasma concentrations of these medicinal products, leading to QTc prolongation and rare occurrences of torsades de pointes (see sections 4.4 and 4.5).
Danish: Samtidig administration med CYP3A4 substraterne terfenadin, astemizol, cisaprid, pimozid, halofantrin eller chinidin, da dette kan resultere i øgede plasmakoncentrationer af disse lægemidler med forlænget QTc og sjældne tilfælde af torsades de pointes til følge (se pkt.
English: paresthesia, dizziness, somnolence, headache convulsion, neuropathy, hypoaesthesia, tremor cerebrovascular accident, encephalopathy, peripheral neuropathy, syncope
Danish: parestesi, svimmelhed, døsighed, hovedpine kramper, neuropati, hypoesthesi, tremor hjerneblødning, encephalopati, perifer neuropati, synkope
English: Study 1899 was a randomised, evaluator-blinded study of posaconazole oral suspension (200 mg three times a day) versus fluconazole suspension (400 mg once daily) or itraconazole oral solution (200 mg twice a day) in neutropenic patients who were receiving cytotoxic chemotherapy for acute myelogenous leukemia or myelodysplastic syndromes.
Danish: Undersøgelse 1899 var en randomiseret, evaluator-blindet undersøgelse af posaconazol oral suspension (200 mg tre gange dagligt) versus fluconazol suspension (400 mg en gang dagligt) eller itraconazol oral opløsning (200 mg to gange dagligt) i neutropeniske patienter, der modtog cytotoksisk kemoterapi for akut myeloid leukemi eller myelodysplastisk syndrom.
English: Rare side effects (occurring in at least 1 in 10,000 patients) are:
Danish: Sjældne bivirkninger (forekommer hos mindst 1 ud af 10.000 personer) er: Lungebetændelse og andre lungeskader
English: liver function tests raised (ALT increased, AST increased, bilirubin increased, alkaline phosphatase increased, GGT increased) hepatocellular damage*, hepatitis, jaundice, hepatomegaly hepatic failure, hepatitis cholestatic, cholestasis,
Danish: forhøjet leverfunktionstests (øget ALT, øget AST, øget bilirubin, øget alkalisk fosfatase, øget GGT) hepatocellulær ødelæggelse٭, hepatitis, gulsot, hepatomegali
English: Posaconazole should be administered with food or a nutritional supplement (see section 4.2).
Danish: Posaconazol skal indgives sammen med et måltid eller ernæringstilskud (se pkt.
English: long QT syndrome§, electrocardiogram abnormal§, palpitations torsade de pointes, sudden death, ventricular tachycardia, cardio-respiratory arrest, cardiac failure, myocardial infarction
Danish: §, unormalt elektrokardiogram Langt QT syndrom palpitationer torsade de pointes, pludselig død, ventrikulær takykardi, kardio-respiratorisk stop, nedsat hjertefunktion, myokardieinfarkt
English: No studies on the effects of posaconazole on the ability to drive and use machines have been performed.
Danish: For posaconazol er der ikke foretaget undersøgelser af indflydelsen på evnen til at føre bil eller betjene maskiner.
English: Study 316 was a randomised, double-blind trial of posaconazole oral suspension (200 mg three times a day) versus fluconazole capsules (400 mg once daily) in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease (GVHD).
Danish: Undersøgelse 316 var en randomiseret, dobbeltblindet undersøgelse af posaconazol oral suspension (200 mg tre gange dagligt) versus fluconazol kapsler (400 mg en gang dagligt) til allogeneisk HSCT modtagere med graft-versus vært sygdom (GVHD).
English: Sodium benzoate (E211) Sodium citrate dihydrate
Danish: Natriumbenzoat (E211)
English: Posaconazole SP is indicated for use in the treatment of the following fungal infections in adults (see section 5.1):
Danish: Posaconazole SP er indiceret til behandling af følgende svampeinfektioner hos voksne (se pkt.
English: Each dose of Posaconazole SP should be taken with food or a nutritional supplement if you are unable to tolerate food to enhance the oral absorption.
Danish: Brug af Posaconazole SP sammen med mad og drikke Hver dosis Posaconazole SP bør indtages sammen med mad eller et ernæringstilskud, hvis De ikke er i stand til at indtage mad for at øge den orale optagelse.
English: Cases of elevated ciclosporin levels resulting in serious adverse events, including nephrotoxicity and one fatal case of leukoencephalopathy, were reported in clinical efficacy studies.
Danish: I kliniske effektundersøgelser rapporteredes tilfælde af stigning i ciclosporinniveauer med alvorlige bivirkninger til følge, inklusive nefrotoksicitet samt et fatalt tilfælde af leukoencephalopati.
English: Midazolam and other benzodiazepines metabolised by CYP3A4: In a study in healthy volunteers posaconazole (200 mg once daily for 10 days) increased the exposure (AUC) of IV midazolam (0.05 mg/kg) by 83 %.
Danish: Midazolam og andre benzodiazepiner som metaboliseres af CYP3A4: I et studie med raske frivillige øgede posaconazol (200 mg en gang daglig i 10 dage) eksponeringen (AUC) af IV midazolam
English: If you are taking simvastatin, lovastatin, atorvastatin and some similar medicines (called HMGCoA reductase inhibitors or statins) that are used to treat high cholesterol levels in the blood.
Danish: • chinidin (anvendes til behandling af unormal hjerterytme) hvis De tager simvastatin, lovastatin, atorvastatin og visse lignende lægemidler (kaldet HMGCoA reduktasehæmmere eller statiner), som bruges til at behandle højt chlolesterolniveau i blodet.
English: • Some medicines used to treat or prevent fits, such as phenytoin, carbamazepine, phenobarbital,
Danish: • Nogle lægemidler anvendt til at behandle eller forhindre krampeanfald, såsom fenytoin,
English: thrombocytopenia, leukopenia, anaemia, eosinophilia, lymphadenopathy haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura, pancytopenia, coagulopathy, haemorrhage
Danish: neutropeni thrombocytopeni, leukopeni, anæmi, eosinofili, lymfadenopati hæmolytisk uræmisk syndrom, thrombotisk thrombocytopenisk purpura, pancytopeni, koagulopati, blødning
English: Clinically significant interactions resulting in hospitalisation and/or posaconazole discontinuation were reported in clinical efficacy studies.
Danish: I kliniske effektundersøgelser rapporteredes klinisk signifikante interaktioner, som resulterede i hospitalsindlæggelse og/eller afbrydelse af behandling med posaconazol.
English: HOW TO TAKE POSACONAZOLE SP Posaconazole SP must only be used as directed by your doctor.
Danish: SÅDAN SKAL DE TAGE POSACONAZOLE SP Posaconazole SP bør altid tages i nøje overensstemmelse med Deres læges instruktioner.
English: If you forget to take Posaconazole SP
Danish: Hvis De har glemt at tage Posaconazole SP
English: After the first day, take 100 mg (2.5 ml) once a day with food or nutritional supplement if you are unable to tolerate food.
Danish: Tag, efter den første dag, 100 mg (2,5 ml) en gang dagligt med mad eller et ernæringstilskud, hvis De ikke er i stand til at indtage føde.
English: In the small number of subjects studied who had hepatic impairment, there was an increase in exposure and half-life with a decrease in hepatic function (see sections 4.4 and 5.2).
Danish: Hos det lille antal testede personer, som havde nedsat leverfunktion, observeredes en øgning i eksponering og halveringstid jo mere leverfunktionen var nedsat (se pkt.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml of oral suspension contains 40 mg of posaconazole.
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING 1 ml oral suspension indeholder 40 mg posaconazol.
English: Infections due to fungi called Coccidioides that have not improved during treatment with one or more of amphotericin B, itraconazole or fluconazole or when these medicines have had to be stopped;
Danish: Infektioner fremkaldt af svampe der kaldes Coccidioides, hvis infektionen ikke er behandlet tilstrækkelig med et eller flere af lægemidlerne amphotericin B, itraconazol og fluconazol eller hvis De har måtte stoppe behandlingen med disse midler;
English: Respiratory, thoracic and mediastinal disorders Rare:
Danish: Sygdomme i åndedrætsorganer, brysthule og mediastinum Sjælden:
English: Efavirenz (400 mg once a day) decreased the Cmax and AUC of posaconazole by 45 % and 50 %, respectively.
Danish: Efavirenz (400 mg en gang daglig) nedsatte Cmax og AUC på posaconazol med henholdsvis 45 % og 50 %.
English: Immune system disorders Uncommon:
Danish: Forstyrrelser i immunsystemet Usædvanlig:
English: Tell your doctor if you are or think you are pregnant before you start to take Posaconazole SP. Do not use Posaconazole SP during pregnancy unless you are told by your doctor.
Danish: Fortæl Deres læge hvis De er eller tror De er gravid før De begynder at tage Posaconazole SP.
English: * During post-marketing surveillance severe hepatic injury with fatal outcome has been reported (see section 4.4).
Danish: ٭Efter markedsføring er der set alvorlige hepatiske skader med dødelig udfald (se pkt.
English: hearing impaired
Danish: forringet hørelse
English: • Any heart rhythm disturbance
Danish: • En hvilken som helst hjerterytmeforstyrrelse.
English: Renal and urinary disorders Uncommon:
Danish: Sygdomme i nyre og urinveje Usædvanlig:
English: Take 400 mg (two 5 ml spoonfuls) of the suspension twice a day with food or with a nutritional supplement if you are unable to tolerate food.
Danish: Tag 400 mg (to 5 ml teskefulde) suspension to gange dagligt med mad eller med et ernæringstiskud, hvis De ikke er i stand til at indtage føde.
English: Take 200 mg (one 5 ml spoonful) three times a day with food or nutritional supplement if you are unable to tolerate food.
Danish: Tag 200 mg (en 5 ml teskefuld) tre gange dagligt med mad eller et ernæringstilskud, hvis De ikke er i stand til at indtage føde.
English: Phenytoin (200 mg once a day) decreased the Cmax and AUC of posaconazole by 41 % and 50 %, respectively.
Danish: Phenytoin (200 mg 1 gang dagligt) nedsatte Cmax og AUC af posaconazol med henholdsvis 41 % og 50 %.
English: Patients receiving remission-induction chemotherapy for acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS) expected to result in prolonged neutropenia and who are at high risk of developing invasive fungal infections;
Danish: - Patienter, der modtager remissions-induktions kemoterapi for akut myeloid leukæmi (AML) eller myelodysplastiske syndromer (MDS), der forventes at resultere i langvarig neutropeni og som har høj risiko for at udvikle invasive svampeinfektioner; - Modtagere af hematopoietisk stamcelle transplantation (HSCT), der undergår en høj-dosis immunosuppressiv behandling for graft versus vært sygdom og som har høj risiko for at udvikle invasive svampeinfektioner.
English: In healthy volunteers under fasting conditions, dividing the total daily dose (800 mg) into 200 mg four times daily compared to 400 mg twice daily, was shown to increase posaconazole exposure by 58 % over 48 hours.
Danish: Under faste steg AUC mindre end i forhold til doser over 200 mg. I fastende raske forsøgspersoner gav en opdeling af den totale daglige dosis (800 mg) på 200 mg fire gange dagligt sammenlignet med 400 mg to gange dagligt en 58 % øget eksponering for posaconazol over 48 timer.
English: In another study in healthy volunteers, repeat dose administration of oral posaconazole (200 mg twice daily for 7 days) increased the Cmax and AUC of IV midazolam (0.4 mg single dose) by an average of 1.3- and 4.6-fold (range 1.7 to 6.4-fold), respectively; Posaconazole 400 mg twice daily for 7 days increased the IV midazolam Cmax and AUC by 1.6 and 6.2-fold (range 1.6 to 7.6-fold), respectively.
Danish: I et andet studie med raske frivillige øgede gentagen administration af oralt posaconazol (200 mg to gange daglig i 7 dage) Cmax og AUC af IV midazolam (0,4 mg enkelt dosis) med et gennemsnit på henholdsvis 1,3 og 4,6 gange (interval 1,7 til 6,4 gange); Posaconazol 400 mg to gange daglig i 7 dage øgede IV midazolam Cmax og AUC med henholdsvis 1,6 og 6,2 gange (interval 1,6 til 7,6 gange).
English: Heart failure or heart attack, heart rhythm disorders Stroke, blood clots in brain, limbs or lungs
Danish: Nedsat hjertefunktion eller hjerteanfald, forstyrret hjerterytme Slagtilfælde, størknet blod i hjerne, lemmer eller lunger Blødning i tarmen
English: Nausea (feeling or being sick), loss of appetite, stomach pain, diarrhoea, upset stomach, vomiting, wind, dry mouth
Danish: Kvalme (føle sig eller være dårlig), appetitløshed, mavesmerte, diarré, mavebesvær, opkastning, luft i maven, mundtørhed
English: Thereafter blood levels of ciclosporin should be monitored carefully during co-administration, and upon discontinuation of posaconazole treatment, and the dose of ciclosporin should be adjusted as necessary.
Danish: Ciclosporins niveau i blodet bør derefter følges omhyggeligt under samtidig indgift og efter afbrydelse af posaconazol behandling, og ciclosporin dosis bør om nødvendigt justeres.
English: Oral posaconazole 800 mg/day in divided doses was evaluated for the treatment of invasive aspergillosis in patients with disease refractory to amphotericin B (including liposomal formulations) or itraconazole or in patients who were intolerant of these medicinal products in a non-comparative salvage therapy trial.
Danish: I en ikke-sammenlignende klinisk undersøgelse blev oral posaconazol 800 mg dagligt fordelt på flere doser vurderet som behandling af invasiv aspergillose hos patienter, som var sygdomsrefraktære for behandling med amphotericin B (inklusive liposomformuleringer) eller itraconazol eller hos patienter, der havde intolerans overfor disse lægemidler.
English: Use in renal impairment: An effect of renal impairment on the pharmacokinetics of posaconazole is not expected and no dose adjustment is recommended (see section 5.2).
Danish: Brug hos patienter med nedsat nyrefunktion: Farmakokinetikken af posaconazol formodes ikke at blive påvirket af nedsat nyrefunktion, og der anbefales ikke dosisjustering (se pkt.
English: Psychiatric disorders Rare:
Danish: Psykiske lidelser Sjælden:
English: As observed with other azole antifungal agents, effects related to inhibition of steroid hormone synthesis were seen in repeated-dose toxicity studies with posaconazole.
Danish: Som for andre antimykotiske azolderivater sås i toksicitetsundersøgelser med gentagen dosering af posaconazol effekt som følge af hæmningen af steroidhormonsyntesen.
English: Inflammation of liver, liver damage, jaundice (yellow colour of the skin or the eyes) Problems with kidney function, failure of the kidneys Menstrual disorder
Danish: Betændelse i lever, leverskader, gulsot (gulfarvning af huden eller øjnene) Problemer med nyrefunktionen, nyresvigt
English: Frequent monitoring for adverse events and toxicity related to antiretroviral agents that are substrates of CYP3A4 is recommended during co-administration with
Danish: Der anbefales hyppig monitorering for bivirkninger og toksicitet relateret til antiretrovirale midler, der er CYP3A4 substrater under samtidig indtagelse med posaconazol.
English: Anaemia, low numbers of cells called platelets that help the blood to clot, low numbers of some types of white blood cells, enlargement of lymph glands
Danish: Usædvanlige bivirkninger (forekommer hos mindst 1 ud af 1.000 personer) er: Blodmangel, lavt antal af celler som kaldes blodplader som hjælper blodet med at størkne, lavt antal af visse typer hvide blodceller, forstørrelse af lymfeknuder Allergisk reaktion
English: Rifabutin: Concomitant use with posaconazole should be avoided unless the benefit to the patient outweighs the risk (see section 4.5).
Danish: Rifabutin: Samtidig behandling med posaconazol bør undgås, medmindre fordelen for patienten opvejer risikoen (se pkt.
English: Prophylaxis of Invasive Fungal Infections
Danish: Forebyggelse af invasive svampeinfektioner
English: Sirolimus: Repeat dose administration of oral posaconazole (400 mg twice daily for 16 days) increased the Cmax and AUC of sirolimus (2 mg single dose) an average of 6.7-fold and 8.9-fold (range 3.1 to 17.5-fold), respectively, in healthy subjects.
Danish: Sirolimus: Gentagen administration af oralt posaconazol (400 mg to gange daglig i 16 dage) øgede Cmax og AUC af sirolimus (2 mg enkelt dosis) med henholdsvist et gennemsnit på 6,7 gange og 8,9 gange (interval 3,1 til 17,5 gange) hos raske forsøgspersoner.
English: Rifamycin antibacterials (rifampicin, rifabutin), certain anticonvulsants (phenytoin, carbamazepine, phenobarbital, primidone), efavirenz and cimetidine: Posaconazole concentrations may be significantly lowered in combination; therefore, concomitant use with posaconazole should be avoided unless the benefit to the patient outweighs the risk (see section 4.5).
Danish: Rifamycin antibakterielle midler (rifampicin, rifabutin), visse antiepileptika (phenytoin, carbamazepin, phenobarbital, primidon), efavirenz og cimetidin: Posaconazolkoncentrationer kan være betydeligt nedsat ved kombination.
English: Heart rhythm problems including very fast heartbeat (palpitations), abnormal findings on heart tests (like ECGs that show heart rhythm)
Danish: Føle- eller bevægelsesforstyrrelser, tremor, krampeanfald Forstyrrelser i hjerterytmen inklusive meget hurtige hjerteslag (palpitationer), unormale fund ved hjerteundersøgelser (som EKG'er, der viser hjerterytme) Højt eller lavt blodtryk
English: Do not breast-feed while being treated with Posaconazole SP.
Danish: Undlad amning under behandling med Posaconazole SP.
English: If you are allergic (hypersensitive) to posaconazole or to any of the other ingredients of Posaconazole SP.
Danish: Tag ikke Posaconazole SP hvis De er overfølsom (allergisk) over for posaconazol eller et af de øvrige indholdsstoffer.
English: • Medicines used to treat HIV called protease inhibitors (including lopinavir and atazanavir,
Danish: • Lægemidler kaldet proteasehæmmere anvendt i HIV behandling (inklusive lopinavir og atazanavir, der gives sammen med ritonavir) og non nukleosid reverse transcriptase hæmmere
English: However, in clinical efficacy trials, the safety profile of posaconazole between the young and elderly patients was similar.
Danish: Sikkerhedsprofilen af posaconazol mellem de unge og ældre patienter, var endvidere tilsvarende i kliniske effekt undersøgelser.
English: § See section 4.4.
Danish: 4.4 and 4.5).
English: vomiting, nausea, abdominal pain, diarrhoea, dyspepsia, dry mouth, flatulence pancreatitis gastrointestinal haemorrhage, ileus
Danish: opkastning, kvalme, abdominal smerte, diarre, dyspepsi, mundtørhed, flatulens pancreatitis blødning i mave/tarm, ileus
English: Sirolimus concentrations should be measured upon initiation, during co-administration, and at discontinuation of posaconazole treatment, with sirolimus doses adjusted accordingly.
Danish: Sirolimus koncentrationer bør måles ved initiering af behandling, under samtidig indtagelse og ved afbrydelse af posaconazolbehandling.
English: Shivering, generally feeling unwell or weak Scattered body pain, including in muscles and joints, back pain Fluid retention, altered medicine levels.
Danish: Skælven, generel følelse af utilpashed eller svaghed Spredte smerter i kroppen, inklusive i muskler og led, rygsmerte
English: Following co-administration of oral posaconazole (400 mg twice daily) with atazanavir and ritonavir (300/100 mg once daily) for 7 days in healthy subjects Cmax and AUC of atazanavir increased by an average of 1.5-fold and 2.5-fold (range 0.9 to 4.1-fold), respectively.
Danish: Efter samtidig indtagelse af oralt posaconazol (400 mg to gange daglig) med atazanavir og ritonavir (300/100 mg en gang daglig) i 7 dage hos raske forsøgspersoner øgedes Cmax og AUC for atazanavir med et gennemsnit på henholdsvis 1,5 gange og 2,5 gange (interval 0,9 til 4,1 gange).
English: pyrexia (fever), asthenia, fatigue oedema, pain, chills, malaise tongue oedema, face oedema
Danish: pyreksi (feber), astheni, træthed ødem, smerte, kuldegysninger, utilpashed tungeødem, ansigtsødem
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each ml of oral suspension contains 40 mg of posaconazole.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER 1 ml oral suspension indeholder 40 mg posaconazol.
English: A MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH
Danish: A. FREMSTILLER AF VIRKSOMHEDSGODKENDELSE ANSVARLIG FOR BATCHFRIGIVELSE
English: Each dose of Posaconazole SP should be administered with a meal, or with a nutritional supplement in patients who cannot tolerate food to enhance the oral absorption and to ensure adequate exposure.
Danish: Hos patienter, der ikke kan tåle fødeindtagelse, gives Posaconazole SP med et ernæringstilskud, for at øge den orale absorption og for at sikre tilstrækkelig optagelse.
English: Sleepiness
Danish: Udslæt
English: Concomitant use of posaconazole and efavirenz should be avoided unless the benefit to the patient outweighs the risk.
Danish: Samtidig anvendelse af posaconazol og efavirenz bør undgås medmindre fordelen for patienten overstiger risikoen.
English: Following co-administration of oral posaconazole (400 mg twice daily) with atazanavir (300 mg once daily) for 7 days in healthy subjects Cmax and AUC of atazanavir increased by an average of 2.6-fold and 3.7-fold (range 1.2 to 26fold), respectively.
Danish: Efter samtidig indtagelse af oralt posaconazol (400 mg to gange daglig) med atazanavir (300 mg en gang daglig) i 7 dage hos raske forsøgspersoner øgedes Cmax og AUC for atazanavir med et gennmsnit på henholdsvis 2,6 gange og 3,7 gange (interval 1,2 til 26 gange).
English: Caution should be used when prescribing Posaconazole SP to patients with hypersensitivity to other azoles.
Danish: Der bør udøves forsigtighed, når Posaconazole SP ordineres til patienter, som er
English: If you have any further questions, ask your doctor or pharmacist.
Danish: Spørg lægen eller på apoteket, hvis der er mere, De vil vide.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING BOTTLE (Outer Carton)
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE
English: Fungal Infections
Danish: Betændelse i bugspytkirtlen
English: There are other medicines that can sometimes be given while you are taking Posaconazole SP but special care may be needed.
Danish: Se de ovenfor nævnte typer medicin, som ikke må anvendes mens De tager Posaconazole SP. Der er anden medicin som af og til kan anvendes samtidigt med at De tager Posaconazole SP, men hvor det kan være nødvendigt at være forsigtig.
English: Hair loss, itching
Danish: Hårtab, kløen
English: Concomitant use of posaconazole and cimetidine should be avoided unless the benefit to the patient outweighs the risk.
Danish: Samtidig administration af posaconazol og cimetidin bør undgås, medmindre fordelen for patienten opvejer risikoen.
English: Therefore, concomitant use of posaconazole and vinca alkaloids should be avoided unless the benefit to the patient outweighs the risk.
Danish: Samtidig administration af posaconazol og vincaalkaloider bør derfor undgås, medmindre fordelen for patienten opvejer risikoen.
English: Posaconazole Fluconazole
Danish: Fluconazol
English: General disorders and administration site conditions Common:
Danish: Almene lidelser og reaktioner på indgivelsesstedet Almindelig: