FrancophonIA/ELRC3.0 huggingface dataset:
English: What Cresemba looks like and contents of the pack Cresemba 100 mg hard capsules are capsules with a reddish-brown body marked with “100” in black ink and a white cap marked with “C” in black ink.
Danish: Cresemba 100 mg hårde kapsler er kapsler med en rødbrun yderside mærket ”100” i sort farve og en hvid hætte mærket "C" i sort farve.
English: CRESEMBA capsules can be taken with or without food.
Danish: CRESEMBA kapsler kan tages med eller uden mad.
English: S-methadone (inactive opiate isomer)
Danish: R-methadon (aktiv opiat-isomer).
English: Isavuconazole
Danish: Isavuconazol
English: Repaglinide (CYP2C8 and OATP1B1 substrate)
Danish: Repaglinid (CYP2C8- og OATP1B1substrat)
English: You will take this dose until your doctor tells you otherwise.
Danish: Du skal tage denne dosis, indtil din læge siger andet.
English: In 5 patients with mucormycosis due to Rhizomucor spp., no favourable responses were observed.
Danish: Hos 5 patienter med mucormycose på grund af Rhizomucor spp.
English: Elevated liver chemistry tests includes events of alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, blood lactate dehydrogenase increased, gamma-glutamyltransferase increased, hepatic enzyme increased, hepatic function abnormal, hyperbilirubinemia, liver function test abnormal, and transaminases increased.
Danish: Forhøjede leverfunktionstest omfatter hændelser med forhøjet alaninaminotransferase, forhøjet aspartataminotransferase, forhøjet alkalisk phosphatase i blodet, forhøjet bilirubin i blodet, forhøjet laktatdehydrogenase i blodet, forhøjet gammaglutamyltransferase, forhøjet leverenzymtal, unormal leverfunktion, hyperbilirubinæmi, unormale leverfunktionstest og forhøjede transaminaser.
English: Antitussives Dextromethorphan (CYP2D6 substrate)
Danish: Antitussiva Dextromethorphan (CYP2D6-substrat)
English: Prednisolone (active metabolite): AUCinf: ↑ 8%
Danish: Prednisolon (aktiv metabolit): AUCinf: ↑ 8%
English: Dabigatran etexilate has a narrow therapeutic index and should be monitored, and dose reduction if required.
Danish: Dabigatranetexilat har et smalt terapeutisk indeks og bør monitoreres.
English: During intravenous administration of isavuconazole, infusion-related reactions including hypotension, dyspnoea, dizziness, paraesthesia, nausea, and headache were reported (see section 4.8).
Danish: Der er indberettet infusionsrelaterede reaktioner under intravenøs administration af isavuconazol, herunder hypotension, dyspnø, svimmelhed, paræstesi, nausea og hovedpine (se pkt.
English: Isavuconazole is a substrate of CYP3A4 and CYP3A5 (see section 5.2).
Danish: Isavuconazol er et substrat af CYP3A4 og CYP3A5 (se pkt.
English: Ketoconazole is contraindicated (see section 4.3).
Danish: Ketoconazol er kontraindiceret (se pkt.
English: Colchicine has a narrow therapeutic index and should be monitored, dose reduction if required.
Danish: Colchicin har et smalt terapeutisk indeks og bør monitoreres.
English: • invasive aspergillosis
Danish: • invasiv aspergillose
English: Symptoms reported more frequently at supratherapeutic doses of CRESEMBA (equivalent to isavuconazole 600 mg/day) evaluated in a QT study than in the therapeutic dose group (equivalent to isavuconazole 200 mg/day dose) included: headache, dizziness, paraesthesia, somnolence, disturbance in attention, dysgeusia, dry mouth, diarrhoea, oral hypoaesthesia, vomiting, hot flush, anxiety, restlessness, palpitations, tachycardia, photophobia and arthralgia
Danish: Symptomer, der blev indberettet oftere ved supraterapeutiske doser af CRESEMBA (svarende til isavuconazol 600 mg/dag) end i gruppen, der fik den terapeutiske dosis (svarende til isavuconazol 200 mg/dag), omfattede: hovedpine, svimmelhed, paræstesi, somnolens, opmærksomhedsforstyrrelser, dysgeusi, mundtørhed, diarré, oral hypoæstesi, opkastning, hedestigninger, angst, uro, palpitationer, takykardi, fotofobi og arthralgi i et QT-studie
English: The recommended dose is one vial once a day.
Danish: Den anbefalede dosis er et hætteglas én gang om dagen.
English: Co-administration of CRESEMBA with medicinal products which are substrates of UGT may result in mildly increased plasma concentrations of these medicinal products.
Danish: Samtidig administration af CRESEMBA og lægemidler, som er substrater af UGT, kan medføre let forhøjede plasmakoncentrationer af disse lægemidler.
English: The infusion solution contains approximately 1.5 mg/mL isavuconazonium sulfate (corresponding to approximately 0.8 mg isavuconazole per mL).
Danish: Infusionsvæsken indeholder cirka 1,5 mg/ml isavuconazoniumsulfat (svarende til cirka 0,8 mg isavuconazol pr. ml).
English: Studies in animals did not show impairment of fertility in male or female rats (see section 5.3).
Danish: Dyreforsøg viste ingen forringelse af fertiliteten hos han- eller hunrotter (se pkt.
English: Cresemba may make you feel confused, tired or sleepy.
Danish: Du kan føle dig forvirret, træt eller søvnig, når du bruger Cresemba.
English: Immunosuppresants Ciclosporin, sirolimus, tacrolimus (CYP3A4/5 substrates)
Danish: Immunsuppressiva Ciclosporin, sirolimus, tacrolimus (CYP3A4/5-substrater)
English: Isavuconazole is a mild CYP2B6 inducer; co-administration of CRESEMBA may result in decreased plasma concentrations of CYP2B6 substrates.
Danish: Isavuconazol er en mild CYP2B6-hæmmer; samtidig administration af CRESEMBA kan medføre reducerede plasmakoncentrationer af CYP2B6-substrater.
English: CRESEMBA is also available as powder for concentrate for solution for infusion containing 200 mg isavuconazole, equivalent to 372 mg isavuconazonium sulfate.
Danish: CRESEMBA fås også som pulver til koncentrat til infusionsvæske, opløsning, indeholdende 200 mg isavuconazol, svarende til 372 mg isavuconazoniumsulfat.
English: The recommended maintenance dose is two capsules (equivalent to 200 mg of isavuconazole) once daily, starting 12 to 24 hours after the last loading dose.
Danish: Den anbefalede vedligeholdelsesdosis er to kapsler (svarende til 200 mg isavuconazol) én gang dagligt, der starter 12-24 timer efter den sidste belastningsdosis.
English: Co-administration with high-dose ritonavir (>200 mg twice daily) is contraindicated, as at high doses ritonavir may induce CYP3A4/5 and decrease isavuconazole plasma concentrations (see section 4.3).
Danish: Samtidig administration af højdosis-ritonavir (>200 mg to gange dagligt) er kontraindiceret, da høje doser ritonavir kan inducere CYP3A4/5 og reducere plasmakoncentrationerne af isavuconazol (se pkt.
English: Tell your doctor straight away if you notice any of the following side effects: - severe blistering of the skin, mouth, eyes or genitals.
Danish: Fortæl det straks til lægen, hvis du bemærker en eller flere af følgende bivirkninger: - kraftig blæredannelse i hud, mund, øjne eller på kønsorganerne.
English: Warfarin (CYP2C9 substrate)
Danish: Warfarin (CYP2C9-substrat)
English: CRESEMBA 100 mg hard capsules Isavuconazole
Danish: CRESEMBA 100 mg hårde kapsler Isavuconazol
English: Cresemba is available in cartons that contain 14 capsules.
Danish: Cresemba fås i pakninger med 14 kapsler.
English: 7-hydroxymetabolite: AUCinf: ↑ 29% Cmax: ↑ 15%
Danish: 7-hydroxymetabolit: AUCinf: ↑ 29% Cmax: ↑ 15%
English: Co-administration with ketoconazole (see section 4.5).
Danish: Samtidig administration af ketoconazol (se pkt.
English: Cyclophosphamide: careful monitoring for any occurrence of lack of efficacy, and dose increase if required..
Danish: Cyclophosphamid: nøje monitorering for eventuel mangel på effekt og om nødvendigt forhøjelse af dosis.
English: The recommended loading dose is two capsules (equivalent to 200 mg of isavuconazole) every 8 hours for the first 48 hours (6 administrations in total).
Danish: Den anbefalede belastningsdosis er to kapsler (svarende til 200 mg isavuconazol) hver 8. time i de første 48 timer (6 administrationer i alt).
English: Excipients: mannitol (E421) and sulfuric acid
Danish: Hjælpestoffer: mannitol (E 421) og svovlsyre
English: Further information regarding the storage conditions after reconstitution and dilution of the medicinal product is provided in section 6.3.
Danish: Yderligere information om opbevaringsforhold efter rekonstitution og fortynding af lægemidlet, se pkt.
English: Short-acting opiates (alfentanyl, fentanyl): careful monitoring for any occurrence of drug toxicity, and dose reduction if required.
Danish: Korttidsvirkende opiater (alfentanyl, fentanyl): nøje monitorering for eventuel forekomst af lægemiddeltoksicitet og om nødvendigt reduktion af dosis.
English: Cresemba 200 mg powder for concentrate for solution for infusion must be reconstituted and diluted prior to infusion.
Danish: Cresemba 200 mg pulver til koncentrat til infusionsvæske, opløsning, skal rekonstitueres og fortyndes inden infusion.
English: Efavirenz concentrations may decrease.
Danish: Efavirenz-koncentrationerne kan falde.
English: Capsule contents magnesium citrate (anhydrous) microcrystalline cellulose talc silica, colloidal anhydrous stearic acid
Danish: Kapselindhold magnesiumcitrat (vandfri) mikrokrystallinsk cellulose talkum kolloid vandfri silica stearinsyre
English: Starting dose for the first two days (48 hours) The recommended dose is one vial three times a day (every 8 hours).
Danish: Startdosis i de første to dage (48 timer) Den anbefalede dosis er et hætteglas tre gange om dagen (hver 8. time).
English: Carbamazepine, phenobarbital and phenytoin (strong CYP3A4/5 inducers)
Danish: Carbamazepin, phenobarbital og phenytoin (potente CYP3A4/5induktorer)
English: Isavuconazole can be considered a moderate inhibitor of CYP3A4/5, and systemic exposure to medicinal products metabolised by CYP3A4 may be increased when co-administered with CRESEMBA.
Danish: Isavuconazol kan anses for at være en moderat hæmmer af CYP3A4/5, og den systemiske eksponering for lægemidler, der metaboliseres af CYP3A4, kan være forhøjet, når de administreres samtidig med CRESEMBA.
English: Lipid-lowering agents Atorvastatin and other statins (CYP3A4 substrates e.g., simvastatin, lovastatin, rosuvastatin) (CYP3A4/5 and/or BCRP substrates))
Danish: Lipidsænkende midler Atorvastatin og andre statiner (CYP3A4-substrater, fx simvastatin, lovastatin, rosuvastatin) (CYP3A4/5- og/eller BCRPsubstrater))
English: Methotrexate (BCRP, OAT1, OAT3 substrate)
Danish: Methotrexat (BCRP-, OAT1-, OAT3substrat)
English: - The other ingredients ingredients are: - Capsule content: magnesium citrate (anhydrous), microcrystalline cellulose, talc, anhydrous colloidal silica, stearic acid.
Danish: - Øvrige indholdsstoffer: - Kapselindhold: magnesiumcitrat (vandfri), mikrokrystallinsk cellulose, talkum, kolloid vandfri silica, stearinsyre.
English: The recommended maintenance dose is one vial after reconstitution and dilution (equivalent to 200 mg of isavuconazole) once daily, starting 12 to 24 hours after the last loading dose.
Danish: Den anbefalede vedligeholdelsesdosis er ét hætteglas efter rekonstitution og fortynding (svarende til 200 mg isavuconazol) én gang dagligt, der starter 12-24 timer efter den sidste belastningsdosis.
English: Prednisone (CYP3A4 substrate)
Danish: Prednison (CYP3A4-substrat)
English: - Capsule shell: hypromellose, water, red iron oxide (E172) (capsule body only), titanium dioxide (E171), gellan gum, potassium acetate, disodium edetate, sodium laurilsulfate.
Danish: - Kapselskal: hypromellose, vand, rød jernoxid (E 172) (kun kapselydersiden), titandioxid (E 171), gellangummi, kaliumacetat, dinatriumedetat, natriumlaurilsulfat.
English: Isavuconazole: AUCtau: ↑ 8% Cmax: ↑ 5%
Danish: Isavuconazol: AUCtau: ↑ 8% Cmax: ↑ 5%
English: Isavuconazole is a moderate inhibitor of CYP3A4/5; co-administration of CRESEMBA with medicinal products which are substrates of CYP3A4/5 may result in increased plasma concentrations of these medicinal products.
Danish: Isavuconazol er en moderat hæmmer af CYP3A4/5; samtidig administration af CRESEMBA og lægemidler, som er substrater af CYP3A4/5, kan medføre forhøjede plasmakoncentrationer af disse lægemidler.
English: Talk to your doctor, pharmacist or nurse before using Cresemba: - if you have had an allergic reaction to other ‘azole' anti-fungal treatments in the past, such as ketoconazole, fluconazole, itraconazole, voriconazole or posaconazole, - if you are suffering from severe liver disease.
Danish: Kontakt lægen, apotekspersonalet eller sundhedspersonalet, før du bruger Cresemba: - hvis du tidligere har haft en allergisk reaktion over for andre behandlinger med ‘azol svampemidler', for eksempel ketoconazol, fluconazol, itraconazol, voriconazol eller posaconazol - hvis du har en alvorlig leversygdom.
English: Talk to your doctor, pharmacist or nurse before taking Cresemba: - if you have had an allergic reaction to other ‘azole' anti-fungal treatments in the past, such as ketoconazole, fluconazole, itraconazole, voriconazole or posaconazole, - if you are suffering from severe liver disease.
Danish: Kontakt lægen, apotekspersonalet eller sundhedspersonalet, før du tager Cresemba: - hvis du tidligere har haft en allergisk reaktion over for andre behandlinger med ‘azol svampemidler', for eksempel ketoconazol, fluconazol, itraconazol, voriconazol eller posaconazol - hvis du har en alvorlig leversygdom.
English: Benzodiazepines Midazolam (CYP3A4/5 substrate)
Danish: Benzodiazepiner Midazolam (CYP3A4/5-substrat)
English: (BCRP inhibition)
Danish: (BCRP-hæmning)
English: Isavuconazole is a mild inhibitor of P-glycoprotein (P-gp); co-administration with CRESEMBA may result in increased plasma concentrations of P-gp substrates.
Danish: Isavuconazol er en mild hæmmer af P-glykoprotein (P-gp); samtidig administration af CRESEMBA kan medføre forhøjede plasmakoncentrationer af P-gp-substrater.
English: In rats, a dose-related increase in the incidence of zygomatic arch fusion was also noted in offspring (see section 4.6).
Danish: Hos rotter blev der hos afkommet også bemærket en dosisrelateret stigning i forekomsten af kindbuefusion (se pkt.
English: Indinavir: careful monitoring for any occurrence of lack of antiviral efficacy, and dose increase if required.
Danish: Indinavir: nøje monitorering for eventuel mangel på antiviral effekt og om nødvendigt forhøjelse af dosis.
English: What Cresemba is used for
Danish: Hvad bruges Cresemba til?
English: Short-acting opiates (alfentanyl, fentanyl) (CYP3A4/5 substrate)
Danish: Korttidsvirkende opiater (alfentanyl, fentanyl) (CYP3A4/5-substrat)
English: One vial of the powder for concentrate for solution for infusion should be reconstituted by addition of 5 mL water for injection to the vial.
Danish: Ét hætteglas med pulver til koncentrat til infusionsvæske, opløsning, skal fortyndes ved tilsætning af 5 ml vand til injektion i hætteglasset.
English: For long-term treatment beyond 6 months, the benefit-risk balance should be carefully considered (see sections 5.1 and 5.3).
Danish: Risk benefit-balance bør overvejes nøje (se pkt.
English: Capsule shell hypromellose water red iron oxide (E172) (capsule body only) titanium dioxide (E171) gellan gum potassium acetate disodium edetate sodium laurilsulfate
Danish: Kapselskal hypromellose vand rød jernoxid (E 172) (kun kapselydersiden) titandioxid (E 171) gellangummi kaliumacetat dinatriumedetat natriumlaurilsulfat
English: Isavuconazole inhibited the hERG potassium channel and the L-type calcium channel with an IC50 of 5.82 µM and 6.57 µM respectively (34- and 38-fold the human non-protein bound Cmax at maximum recommended human dose [MRHD], respectively).The in vivo 39-week repeated-dose toxicology studies in monkeys did not show QTcF prolongation at doses up to 40 mg/kg/day (2.1-fold the recommended clinical maintenance dose, based on mg/m2/day comparisons).
Danish: Isavuconazol hæmmede hERG-kaliumkanalen og L-type-calciumkanalen med en IC50 på henholdsvis 5,82 µM og 6,57 µM (henholdsvis 34 og 38 gange det humane ikke-proteinbundne Cmax ved den maksimale anbefalede humane dosis [MRHD]).
English: What you need to know before you use Cresemba 3.
Danish: Det skal du vide, før du begynder at bruge Cresemba 3.
English: - phenytoin, used for epilepsy, - St John's wort, a herbal medicine used for depression, - efavirenz, etravirine, used for HIV, - nafcillin, used for bacterial infections.
Danish: - phenytoin, der bruges til behandling af epilepsi - Johannesurt - et naturlægemiddel, der bruges til behandling af depression - efavirenz, etravirin, der bruges til behandling af hiv - nafcillin, der bruges til behandling af bakterieinfektioner
English: Co-administration of medicinal products which are inducers of CYP3A4 and/or CYP3A5 may decrease the plasma concentrations of isavuconazole.
Danish: Samtidig administration af lægemidler, der er induktorer af CYP3A4 og/eller CYP3A5 kan reducere plasmakoncentrationerne af isavuconazol.
English: Antiretroviral agents Lopinavir 400 mg / Ritonavir 100 mg (CYP3A4/5 strong inhibitors and substrates)
Danish: Antiretrovirale midler Lopinavir 400 mg / ritonavir 100 mg (potente hæmmere og substrater af CYP3A4/5)
English: The population pharmacokinetic evaluation of isavuconazole in healthy subjects and patients with mild or moderate hepatic dysfunction demonstrated that the mild and moderate hepatic impairment populations had 40% and 48% lower isavuconazole clearance (CL) values, respectively, than the healthy population.
Danish: De gennemsnitlige plasmakoncentrationer (Cmax) var 2% lavere i gruppen fra Child-Pugh-klasse A og 30% lavere i gruppen fra Child-Pughklasse B. Undersøgelsen af isavuconazols populationsfarmakokinetik på raske personer og patienter med mild eller moderat nedsat leverfunktion viste, at populationerne med mild og moderat nedsat leverfunktion havde henholdsvis 40% og 48% lavere clearance-værdier (CL) af isavuconazol end den raske population.
English: - Printing ink: shellac, propylene glycol, potassium hydroxide, black iron oxide (E172).
Danish: - Blækfarve: shellak, propylenglycol, kaliumhydroxid, sort jernoxid (E 172).
English: Daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantrone, topotecan concentrations may increase.
Danish: Koncentrationerne af daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantron eller topotecan kan stige.
English: The recommended loading dose is one vial after reconstitution and dilution (equivalent to 200 mg of isavuconazole) every 8 hours for the first 48 hours (6 administrations in total).
Danish: Den anbefalede belastningsdosis er ét hætteglas efter rekonstitution og fortynding (svarende til 200 mg isavuconazol) hver 8. time i de første 48 timer (6 administrationer i alt).
English: Cyclophosphamide (CYP2B6 substrate)
Danish: Cyclophosphamid (CYP2B6-substrat)
English: (P-gp inhibition)
Danish: (P-gp-hæmning)
English: Antiarrhythmics Digoxin (P-gp substrate)
Danish: Antiarytmika Digoxin (P-gp-substrat)
English: Omeprazole (CYP2C19 substrate and gastric pH )
Danish: Omeprazol (CYP2C19-substrat og gastrisk pH )
English: Skin problems Tell your doctor straight away if you get severe blistering of the skin, mouth, eyes or genitals.
Danish: Fortæl det straks til lægen, hvis du får kraftig blæredannelse i huden, munden, øjnene eller på kønsorganerne.
English: Half-life (h)
Danish: Halveringstid (t)
English: No dose adjustment is warranted for moderate to mild CYP3A4/5 inhibitors.
Danish: Justering af dosis ved moderate til milde CYP3A4/5-hæmmere er ikke berettiget.
English: CRESEMBA is also available as hard capsules containing 100 mg isavuconazole, equivalent to 186 mg isavuconazonium sulfate.
Danish: CRESEMBA fås også som hård kapsel indeholdende 100 mg isavuconazol, svarende til 186 mg isavuconazoniumsulfat.
English: Do not breast-feed if you are taking Cresemba.
Danish: Lad være med at amme, hvis du tager Cresemba.
English: Printing ink shellac propylene glycol potassium hydroxide black iron oxide (E172)
Danish: Blækfarve shellak propylenglycol kaliumhydroxid sort jernoxid (E 172)
English: Co-administration with high-dose ritonavir (>200 mg every 12 hours) (see section 4.5).
Danish: Samtidig administration af høje doser ritonavir (200 mg hver 12. time) (se pkt.
English: Co-administration with strong CYP3A4/5 inducers such as rifampicin, rifabutin, carbamazepine, longacting barbiturates (e.g. phenobarbital), phenytoin and St. John's wort or with moderate CYP3A4/5 inducers such as efavirenz, nafcillin and etravirine (see section 4.5).
Danish: Samtidig administration af potente CYP3A4/5-hæmmere såsom rifampicin, rifabutin, carbamazepin, langtidsvirkende barbiturater (fx phenobarbital), phenytoin og Johannesurt eller af moderate CYP3A4/5-induktorer såsom efavirenz, nafcillin og etravirin (se pkt.
English: In 9 patients with mucormycosis due to Rhizopus spp., 4 patients showed a favourable response to isavuconazole.
Danish: Ud af 9 patienter med mucormycose på grund af Rhizopus spp.
English: Other NNRTI (e.g., delavirdine, and nevirapine) (CYP3A4/5 and 2B6 inducers and substrates)
Danish: Andre NNRTI'er (fx delavirdin og nevirapin) (CYP3A4/5- og 2B6induktorer og -substrater)
English: After a single 100 mg dose of isavuconazole was administered to 32 patients with mild (Child-Pugh Class A) hepatic insufficiency and 32 patients with moderate (Child-Pugh Class B) hepatic insufficiency (16 intravenous and 16 oral patients per Child-Pugh class), the least square mean systemic exposure (AUC) increased 64% in the Child-Pugh Class A group, and 84% in the Child-Pugh Class B group, relative to 32 age- and weight-matched healthy subjects with normal hepatic function.
Danish: Efter at en enkelt dosis isavuconazol på 100 mg blev administreret til 32 patienter med mild (ChildPugh-klasse A) nedsat leverfunktion og 32 patienter med moderat (Child-Pugh-klasse B) nedsat leverfunktion (16 intravenøse og 16 orale patienter iht.
English: Co-administration of CRESEMBA with potent CYP3A4/5 inducers such as rifampicin, rifabutin, carbamazepine, long-acting barbiturates (e.g., phenobarbital), phenytoin and St. John's wort, or with moderate CYP3A4/5 inducers such as efavirenz, nafcillin and etravirine, is contraindicated, since these medicinal products can significantly decrease plasma concentrations of isavuconazole (see section 4.3).
Danish: Samtidig administration af CRESEMBA og potente CYP3A4/5-hæmmere såsom rifampicin, rifabutin, carbamazepin, langtidsvirkende barbiturater (fx phenobarbital), phenytoin og Johannesurt eller med moderate CYP3A4/5-induktorer, såsom efavirenz, nafcillin og etravirin, er kontraindiceret, da disse lægemidler kan reducere plasmakoncentrationerne af isavuconazol markant (se pkt.
English: What you need to know before you take Cresemba 3.
Danish: Det skal du vide, før du begynder at tage Cresemba 3.
English: Co-administration of CRESEMBA with the strong CYP3A4/5 inhibitor ketoconazole is contraindicated, since this medicinal product can significantly increase plasma concentrations of isavuconazole (see sections 4.3 and 4.5).
Danish: Samtidig administration af CRESEMBA og den potente CYP3A4/5-hæmmer ketoconazol er kontraindiceret, da dette lægemiddel kan forhøje plasmakoncentrationerne af isavuconazol markant (se pkt.
English: Unless your doctor tells you otherwise, do not take this medicine and tell your doctor or pharmacist if you are taking any of the following medicines: - rufinamide or other medicines which decrease the QT interval on the heart tracing (ECG), - aprepitant, used to prevent nausea and vomiting by cancer treatment, - prednisone, used for rheumatoid arthritis, - pioglitazone, used for diabetes.
Danish: Fortæl det til lægen eller apotekspersonalet og lad være med at tage dette lægemiddel, medmindre din læge har oplyst andet, hvis du bruger et af nedenstående lægemidler: - rufinamid eller andre lægemidler, der nedsætter QT-intervallet på elektrokardiogram (ekg) - aprepitant, der bruges til at forebygge kvalme og opkastning efter kræftbehandling - prednison, der bruges til behandling af leddegigt (rheumatoid arthritis) - pioglitazon, der bruges til behandling af diabetes
English: No dose adjustment is necessary for elderly patients; however the clinical experience in elderly patients is limited.
Danish: Den kliniske erfaring med anvendelse til ældre patienter er imidlertid begrænset.
English: How to store Cresemba 6.
Danish: Sådan skal du tage Cresemba 4.