FrancophonIA/ELRC3.0 huggingface dataset:
English: The incidence rate in abatacept-treated patients was 3.8 per 100 person-years in the cumulative period.
Croatian: Stopa incidencije u bolesnika liječenih abataceptom tijekom kumulativnog razdoblja iznosila je 3,8 na 100 bolesnik-godina.
English: The efficacy of subcutaneous abatacept in children 2 to 17 years of age is based on pharmacokinetic exposure and extrapolation of established efficacy from intravenous abatacept in pJIA patients and subcutaneous abatacept in adult patients with RA, and is supported by data from an ongoing clinical study.
Croatian: Djelotvornost supkutane formulacije abatacepta u djece u dobi od 2 do 17 godina temelji se na farmakokinetičkoj izloženosti i ekstrapolaciji podataka o dokazanoj djelotvornosti iz ispitivanja intravenske formulacije abatacepta u bolesnika s pJIA-om i supkutane formulacije abatacepta u odraslih bolesnika s reumatoidnim artritisom, a podupiru je i podaci iz kliničkog ispitivanja koje je još u tijeku.
English: Using your other hand, gently pinch the area of skin you cleaned.
Croatian: Drugom rukom nježno uhvatite u nabor područje kože koje ste očistili.
English: Response rates at the end of Period A, at the end of Period B and after 5 years exposure in Period C are summarized in Table 10:
Croatian: Stope odgovora na liječenje na kraju Razdoblja A, na kraju Razdoblja B i nakon 5 godina izloženosti u Razdoblju C prikazani su u Tablici 10:
English: ** p < 0.01, abatacept vs. placebo.
Croatian: ** p < 0,01, abatacept naspram placeba.
English: The geometric mean (CV%) cmin at day 169 were 7.8 mcg/mL (56.3%) for the 3/3 mg/kg, 24.3 mcg/mL (40.8%) for 10/10 mg/kg, and 26.6 mcg/mL (39.0%) for the 30/10 mg/kg regimens.
Croatian: Geometrijska srednja vrijednost (CV%) Cmin 169. dana iznosila je 7,8 μg/ml (56,3%) za režim doziranja 3/3 mg/kg, 24,3 μg/ml (40,8%) za režim doziranja 10/10 mg/kg te 26,6 μg/ml (39,0%) za režim doziranja 30/10 mg/kg.
English: Check the liquid through the viewing window.
Croatian: Pregledajte tekućinu kroz prozor za provjeru.
English: Some vaccines should not be given while you are receiving ORENCIA.
Croatian: Neka cjepiva se ne smiju davati dok primate lijek ORENCIA.
English: Most randomised Period B patients entered Period C (58/60 Period B abatacept recipients; 59/62 Period B placebo recipients), as did 36 of the 47 Period A non-responders (n=153 total patients).
Croatian: U Razdoblje C ušla je većina bolesnika randomiziranih u Razdoblje B (58/60 bolesnika koji su u Razdoblju B primali abatacept; 59/62 bolesnika koji su u Razdoblju B primali placebo) kao i 36 od 47 bolesnika koji nisu odgovorili na liječenje u Razdoblju A (n = 153 bolesnika ukupno).
English: If any serious allergic or anaphylactic reaction occurs, intravenous or subcutaneous ORENCIA therapy should be discontinued immediately and appropriate therapy initiated, and the use of ORENCIA should be permanently discontinued.
Croatian: U slučaju ozbiljne alergijske ili anafilaktičke reakcije, intravenska ili supkutana primjena lijeka ORENCIA mora se odmah prekinuti i započeti odgovarajuća terapija, a liječenje lijekom ORENCIA mora se trajno obustaviti
English: You will find detailed instructions for the preparation and administration of ORENCIA at the end of this leaflet (see "Important instructions for use").
Croatian: Detaljne upute za pripremu i primjenu lijeka ORENCIA pronaći ćete na kraju ove upute o lijeku (pogledajte dio "Važne upute za uporabu")
English: It is important that you tell your baby's doctors and other health care professionals about your ORENCIA use during your pregnancy so they can decide when your baby should receive any vaccine.
Croatian: Važno je da obavijestite liječnike i druge zdravstvene radnike koji skrbe o Vašem djetetu o tome da ste primali lijek ORENCIA tijekom trudnoće, kako bi oni mogli odlučiti kada Vaše dijete treba primiti bilo koje cjepivo..
English: There is limited experience with use of abatacept in combination with TNF-inhibitors (see section 5.1).
Croatian: Ograničeno je iskustvo s primjenom abatacepta u kombinaciji s TNF-inhibitorima (vidjeti dio 5.1).
English: 27% 29%*** 6% NAd
Croatian: 27% 29%*** 6% NDd
English: ORENCIA should not be used with biological medicines for rheumatoid arthritis, including TNFblockers like adalimumab, etanercept, and infliximab; there is not enough evidence to recommend its being given with anakinra and rituximab.
Croatian: ORENCIA se ne smije primjenjivati zajedno s biološkim lijekovima za liječenje reumatoidnog artritisa, uključujući TNF-blokatore kao što su adalimumab, etanercept i infliksimab; nema dovoljno dokaza da bi se mogla preporučiti istodobna primjena s anakinrom i rituksimabom.
English: Participants in Period C at day 1765 included 33 of the 58 Period B abatacept recipients, 30 of the 59 Period B placebo recipients, and 13 of the 36 Period A non-responders.
Croatian: Sudionici u Razdoblju C 1765. dana uključivali su: 33 od 58 bolesnika koji su u Razdoblju B primali abatacept, 30 od 59 bolesnika koji su u Razdoblju B primali placebo i 13 od 36 bolesnika koji nisu odgovorili na liječenje u Razdoblju A.
English: This medicinal product contains 34.5 mg sodium per maximum dose of 4 vials (8.625 mg sodium per vial), equivalent to 1.7% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Croatian: Ovaj lijek sadrži 34,5 mg natrija po najvećoj dozi od 4 bočice (8,625 mg natrija po bočici), što odgovara 1,7% maksimalnog dnevnog unosa od 2 g natrija za odraslu osobu prema preporuci Svjetske zdravstvene organizacije (SZO).
English: After reconstitution, each mL contains 25 mg of abatacept.
Croatian: Nakon rekonstitucije, jedan ml sadrži 25 mg abatacepta.
English: In abatacept-treated patients in studies II and III, statistically significant improvement in the ACR 20 response versus placebo was observed after administration of the first dose (day 15), and this improvement remained significant for the duration of the studies.
Croatian: U bolesnika liječenih abataceptom u ispitivanjima II i III opaženo je statistički značajno poboljšanje odgovora ACR20 naspram placeba nakon primjene prve doze (15. dan) i to je poboljšanje ostalo značajno tijekom cjelokupnog trajanja ispitivanja.
English: ORENCIA should be given to you again, 2 and then 4 weeks after the first infusion.
Croatian: Lijek ORENCIA morate ponovno primiti nakon 2 te zatim 4 tjedna nakon prve infuzije.
English: ORENCIA is used to treat rheumatoid arthritis and psoriatic arthritis in adults.
Croatian: ORENCIA se primjenjuje za liječenje reumatoidnog artritisa i psorijatičnog artritisa u odraslih osoba.
English: ORENCIA should not be used in pregnant women unless clearly necessary.
Croatian: ORENCIA se ne smije primjenjivati u trudnica, osim ako to nije neophodno.
English: You must stop breast-feeding if you are being treated with ORENCIA and for up to 14 weeks after the last dose.
Croatian: Morate prekinuti dojenje ako se liječite lijekom ORENCIA i do 14 tjedana nakon zadnje doze.
English: During the open-label periods of studies I, II, III, and VI the improvement in physical function has been maintained through 7 years, 5 years, 5 years, and 2 years, respectively.
Croatian: U otvorenim razdobljima ispitivanja I, II, III i VI, poboljšanje fizičke funkcije održalo se tijekom 7 godina u ispitivanju I, tijekom 5 godina u ispitivanjima II i III te tijekom 2 godine u ispitivanju VI.
English: One mL pre-filled syringe (Type 1 glass) in a pre-filled pen.
Croatian: Napunjena štrcaljka volumena jedan ml (staklo tipa 1) u napunjenoj brizgalici.
English: If needed, you may apply a small adhesive plaster to the injection site.
Croatian: Ako je potrebno, možete staviti mali flaster preko mjesta injekcije.
English: Long-term extension period
Croatian: Dugoročno razdoblje nastavka ispitivanja
English: What you need to know before you use ORENCIA
Croatian: Što morate znati prije nego počnete primati lijek ORENCIA
English: Response rates at the end of Period A, at the end of Period B and after 5 years exposure in Period C are summarized in Table 9:
Croatian: Stope odgovora na liječenje na kraju Razdoblja A, na kraju Razdoblja B i nakon 5 godina izloženosti u Razdoblju C prikazani su u Tablici 9:
English: If you forget to use ORENCIA
Croatian: Ako ste zaboravili primijeniti lijek ORENCIA
English: The safety of administering live vaccines to infants exposed to abatacept in utero is unknown.
Croatian: Sigurnost primjene živih cjepiva u novorođenčadi izložene abataceptu in utero nije poznata.
English: Mean steady-state trough concentrations were approximately 25 mcg/mL, and mean Cmax concentrations were approximately 290 mcg/mL.
Croatian: Prosječne najniže koncentracije u stanju dinamičke ravnoteže iznosile su približno 25 μg/ml, a prosječne Cmax koncentracije približno 290 µg/ml.
English: Postmarketing reports of systemic injection reactions (e.g. pruritus, throat tightness, dyspnea) have been received following the use of subcutaneous ORENCIA.
Croatian: Nakon stavljanja lijeka u promet prijavljena su izvješća o sistemskim reakcijama na injekciju (npr. svrbež, stezanje grla, dispneja) nakon supkutane primjene lijeka ORENCIA.
English: Your doctor may also do tests to examine your blood values.
Croatian: Liječnik može obavljati i pretrage kako bi Vam provjerio krvnu sliku.
English: ORENCIA 125 mg solution for injection in pre-filled syringe with orange plunger packs of 1, or 4 pre-filled syringes and multipack containing 12 pre-filled syringes (3 packs of packs of 1, 3, or 4 pre-filled syringes with needle guard and multipack containing 12 pre-filled syringes with needle guard (3 packs of 4).
Croatian: ORENCIA 125 mg otopina za injekciju u napunjenoj štrcaljki pakiranja od 1 ili 4 napunjene štrcaljke i višestruko pakiranje koje sadrži 12 napunjenih štrcaljki (3 pakiranja po 4) pakiranja od 1, 3 ili 4 napunjene štrcaljke sa štitnikom za iglu i višestruko pakiranje koje sadrži 12 napunjenih štrcaljki sa štitnikom za iglu (3 pakiranja po 4)
English: 15% NA
Croatian: 15% ND
English: Subjects entering the long term extension after 1 year of double blind treatment all received abatacept treatment and radiographic progression was investigated through year 5.
Croatian: Svi ispitanici koji su nakon godinu dana dvostruko slijepog liječenja ušli u dugoročni nastavak ispitivanja primali su abatacept te je radiografski procijenjena progresija bolesti tijekom 5-godišnjeg liječenja.
English: For patients 2 to 17 years of age with polyarticular juvenile idiopathic arthritis, the recommended weekly dose of ORENCIA solution for injection in pre-filled syringe is based on body weight:
Croatian: Za bolesnike s poliartikularnim juvenilnim idiopatskim u dobi od 2 do 17 godina preporučena tjedna doza ORENCIA otopine za injekciju u napunjenoj štrcaljki temelji se na tjelesnoj težini:
English: ORENCIA is supplied as a powder for solution for infusion.
Croatian: ORENCIA se isporučuje u obliku praška za otopinu za infuziju.
English: ORENCIA can be given as monotherapy in case of intolerance to methotrexate or when treatment with methotrexate is inappropriate.
Croatian: ORENCIA se može primjenjivati kao monoterapija u slučaju nepodnošenja metotreksata ili kada liječenje metotreksatom nije prikladno.
English: The risk of disease flare for patients continuing on abatacept was less than one third that for placebo-treated patients (hazard ratio estimate=0.31; 95% CI
Croatian: Rizik od razbuktavanja bolesti u bolesnika koji su nastavili primati abatacept iznosio je manje od trećine toga rizika u bolesnika koji su primali placebo (procijenjeni omjer rizika = 0,31; 95% CI: 0,16; 0,59).
English: Therefore, concurrent therapy with abatacept and a TNF-inhibitor is not recommended.
Croatian: Stoga se ne preporučuje istodobna terapija abataceptom i TNF-inhibitorom.
English: the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients who responded inadequately to previous therapy with one or more disease-modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX) or a tumour necrosis factor (TNF)-alpha inhibitor.
Croatian: liječenje umjerenog do teškog oblika aktivnog reumatoidnog artritisa (RA) u odraslih bolesnika koji nisu dovoljno dobro odgovorili na prethodnu terapiju jednim ili više lijekova koji modificiraju tijek bolesti (engl. disease-modifying anti-rheumatic drugs, DMARD), uključujući metotreksat (MTX) ili inhibitor faktora nekroze tumora (TNF)-alfa.
English: 50 mg/0.4 mL: white Plunger
Croatian: 50 mg/0,4 mL: bijeli klip
English: Bristol-Myers Squibb Co. 38 Jackson Road Devens, MA 01434 USA
Croatian: 38 Jackson Road Devens, MA 01434 SAD
English: 42% 48%*** 18% NAd
Croatian: 42% 48%*** 18% NDd
English: Remove the needle cover by holding the body of the pre-filled syringe with one hand and pulling the cover straight off with your other hand.
Croatian: Da biste skinuli poklopac igle jednom rukom uhvatite tijelo štrcaljke, a drugom povucite poklopac ravno s igle.
English: The incidence rate of autoimmune disorders in abatacept-treated patients during the double-blind period was 8.8 (7.6, 10.1) per 100 person-years of exposure and for placebo-treated patients was 9.6 (7.9, 11.5) per 100 person-years of exposure.
Croatian: Stopa incidencije autoimunih bolesti u bolesnika liječenih abataceptom tijekom dvostruko slijepog razdoblja iznosila je 8,8 (7,6; 10,1) na 100 bolesnik-godina izloženosti, dok je u bolesnika koji su primali placebo iznosila 9,6 (7,9; 11,5) na 100 bolesnik-godina izloženosti.
English: The pharmacokinetics of abatacept is similar in adult RA and paediatric pJIA patients except for the higher SC absorption in pJIA patients.
Croatian: Farmakokinetika abatacepta slična je u odraslih bolesnika s reumatoidnim artritisom i pedijatrijskih bolesnika s pJIA-om, uz izuzetak veće apsorpcije kod supkutane primjene u bolesnika s pJIA-om.
English: In study SC-I, ACR responses were assessed at 5 years with 85% (356/421) ACR 20 responses, 66% (277/423) ACR 50 responses, and 45% (191/425) ACR 70 responses.
Croatian: U ispitivanju SC-I, ACR odgovori ocijenjeni su nakon 5 godina pri čemu je njih 85% postiglo odgovor ACR 20 (356/421), njih 66% odgovor ACR 50 (277/423), te njih 45% odgovor ACR 70 (191/425).
English: In a mouse carcinogenicity study, increases in the incidence of malignant lymphomas and mammary gland tumours (in females) occurred.
Croatian: U ispitivanju kancerogenosti na miševima došlo je do povećane incidencije malignih limfoma i tumora mliječnih žlijezda (u ženki).
English: Contact your doctor or pharmacist for assistance.
Croatian: Obratite se za pomoć svom liječniku ili ljekarniku.
English: 39% NAe
Croatian: 39% NDe
English: In carcinogenicity studies in mice, an increase in lymphomas and mammary tumours were noted.
Croatian: U ispitivanjima kancerogenosti na miševima opažen je porast broja limfoma i tumora mliječnih žlijezda.
English: What ORENCIA looks like and contents of the pack ORENCIA powder for concentrate for solution for infusion is a white to off-white powder that can appear solid or broken into pieces.
Croatian: ORENCIA prašak za koncentrat za otopinu za infuziju je bijeli do bjelkasti prašak, koji može biti cjelovit ili razlomljen na komadiće.
English: 23% NA
Croatian: 23% ND
English: Greater improvement (p < 0.001) in DAS28 was observed with abatacept and with infliximab compared to placebo at six months in the placebo-controlled portion of the trial; the results between the abatacept and infliximab groups were similar.
Croatian: U placebom kontroliranom dijelu ispitivanja su nakon 6 mjeseci zabilježena veća poboljšanja (p < 0,001) indeksa DAS28 kod primjene abatacepta i infliksimaba u odnosu na placebo; rezultati u skupinama liječenima abataceptom i infliksimabom bili su podjednaki.
English: If your injection is administered by a caregiver, this person must also handle the syringe carefully to prevent accidental needle stick injury and possibly spreading infection.
Croatian: Ako Vam injekciju daje skrbnik, on također mora pažljivo rukovati štrcaljkom kako bi spriječio nehotičnu ozljedu iglom i mogući prijenos infekcije.
English: In study II, among patients with clinically meaningful improvement at month 12, 88% retained the response at month 18, and 85% retained the response at month 24.
Croatian: Među bolesnicima koji su imali klinički značajno poboljšanje nakon 12 mjeseci u ispitivanju II, odgovor se održao u njih 88% nakon 18 mjeseci, a u njih 85% nakon 24 mjeseca.
English: MARKETING AUTHORISATION NUMBERS
Croatian: BROJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: Patients were allowed to receive stable doses of concomitant methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, low dose corticosteroids (equivalent to ≤ 10 mg of prednisone) and/or NSAIDs during the trial.
Croatian: Bolesnicima je tijekom ispitivanja bilo dopušteno istodobno primati stabilne doze metotreksata, sulfasalazina, leflunomida, hidroksiklorokina, niske doze kortikosteroida (ekvivalentne ≤ 10 mg prednizona) i/ili NSAIL-e.
English: Tell your doctor as soon as possible if you notice any of the following: feeling generally unwell, dental problems, burning sensation during urination, painful skin rash, painful skin blisters, coughing
Croatian: Što prije obavijestite liječnika ako primijetite bilo što od sljedećeg: opće loše osjećanje, tegobe sa zubima, pečenje pri mokrenju, bolni osip kože, bolne mjehuriće na koži, kašalj
English: Before you use ORENCIA, your doctor will examine you for tuberculosis or do a skin test. if you have viral hepatitis tell your doctor.
Croatian: Prije nego što primijenite lijek ORENCIA, liječnik će Vas pregledati ili učiniti kožni test da utvrdi imate li tuberkulozu. ako imate virusni hepatitis, obavijestite o tome svog liječnika.
English: In study VI, the mean change in TSS at 12 months was significantly lower in patients treated with abatacept plus methotrexate compared to those treated with methotrexate plus placebo.
Croatian: U ispitivanju VI, prosječna vrijednost promjene TSS-a nakon 12 mjeseci bila je značajno manja u bolesnika liječenih abataceptom i metotreksatom u odnosu na one koji su primali metotreksat i placebo.
English: During the 24-week placebo-controlled period in the larger study PsA-II, the proportion of patients with adverse reactions was similar in the abatacept and placebo treatment groups (15.5% and 11.4%, respectively).
Croatian: U 24-tjednom placebom kontroliranom razdoblju u sklopu većeg kliničkog ispitivanja (PsA-II), udio bolesnika s nuspojavama bio je sličan u skupini liječenoj abataceptom i u onoj koja je primala placebo (15,5% odnosno 11,4%).
English: From a 100 mL infusion bag or bottle, withdraw a volume of 0.9% sodium chloride injection equal to the volume of the reconstituted ORENCIA vials.
Croatian: Iz 100-mililitarske infuzijske vrećice ili boce izvucite volumen otopine 0,9% natrijevog klorida za injekciju jednak volumenu pripremljenih bočica lijeka ORENCIA.
English: In the placebo-controlled clinical trials with abatacept, infections at least possibly related to treatment were reported in 22.7% of abatacept-treated patients and 20.5% of placebo-treated patients.
Croatian: U placebom kontroliranim kliničkim ispitivanjima s abataceptom, infekcije koje su bile barem moguće povezane s liječenjem prijavljene su u 22,7% bolesnika liječenih abataceptom i 20,5% bolesnika koji su primali placebo.
English: The pJIA IV study included 190 patients in the 6 to 17 year age cohort.
Croatian: Ispitivanje pJIA IV uključivalo je kohortu sa190 bolesnika u dobi od 6 do 17 godina.
English: Dose-dependent reductions were observed with abatacept in serum levels of soluble interleukin2 receptor, a marker of T lymphocyte activation; serum interleukin-6, a product of activated synovial macrophages and fibroblast-like synoviocytes in rheumatoid arthritis; rheumatoid factor, an autoantibody produced by plasma cells; and C-reactive protein, an acute phase reactant of inflammation.
Croatian: Kod primjene abatacepta opaženo je o dozi ovisno smanjenje serumskih koncentracija topivih receptora interleukina-2 (biljega aktivacije T-limfocita), interleukina-6 (proizvoda aktiviranih sinovijskih makrofaga i sinoviocita nalik fibroblastima u reumatoidnom artritisu), reumatoidnog faktora (autoantitijela koje proizvode plazmatske stanice) te C-reaktivnog proteina (reaktanta u akutnoj fazi upale).
English: Medicinal products that affect the immune system, including abatacept, may blunt the effectiveness of some immunisations.
Croatian: Lijekovi koji djeluju na imunološki sustav, uključujući abatacept, mogu umanjiti učinkovitost nekih cijepljenja.
English: Blood glucose testing
Croatian: Mjerenje glukoze u krvi
English: Before you are given ORENCIA, your doctor will examine you for tuberculosis or do a skin test. if you have viral hepatitis tell your doctor.
Croatian: Prije nego što primite lijek ORENCIA, liječnik će Vas pregledati ili učiniti kožni test da utvrdi imate li tuberkulozu. ako imate virusni hepatitis, obavijestite o tome svog liječnika.
English: Psoriatic arthritis is an inflammatory disease of the joints, usually accompanied by psoriasis, an inflammatory disease of the skin.
Croatian: Psorijatični artritis je upalna bolest zglobova obično praćena psorijazom (upalnom bolešću kože).
English: More than 100 kg
Croatian: Više od 100 kg
English: 10 kg to less than 25 kg
Croatian: Doza od 10 kg do manje od 25 kg
English: At 24 months, 50.6% (127/251) [95% CI: 44.4, 56.8] of patients in abatacept and 53.3% (130/244) [95% CI: 47.0, 59.5] of patients in adalimumab groups achieved DAS 28 < 2.6.
Croatian: U 24. mjesecu je 50,6% (127/251) [95% CI: 44,4; 56,8] bolesnika u skupini koja je primala abatacept i 53,3% (130/244) [95% CI: 47,0; 59,5] bolesnika u skupini koja je primala adalimumab postiglo DAS 28 rezultat < 2,6.
English: DO NOT RECAP the pre-filled syringe at any time, as this may damage, bend, or break the needle.
Croatian: NEMOJTE NIKADA VRAĆATI ZATVARAČ na napunjenu štrcaljku jer tako možete oštetiti, saviti ili slomiti iglu.
English: Co-administration of ORENCIA with biologic immunosuppressive or immunomodulatory agents could potentiate the effects of abatacept on the immune system (see section 4.5).
Croatian: Istodobna primjena lijeka ORENCIA s biološkim imunosupresivnim ili imunomodulatornim lijekovima može pojačati učinke abatacepta na imunološki sustav (vidjeti dio 4.5).
English: Solution for injection (injection) in pre-filled pen (ClickJect).
Croatian: Otopina za injekciju (injekcija) u napunjenoj brizgalici (ClickJect).
English: Uncommon Conjunctivitis, dry eye, visual acuity reduced
Croatian: Poremećaji oka manje često konjunktivitis, suhe oči, smanjena oštrina vida
English: Patients were allowed to receive stable doses of concomitant methotrexate, low dose corticosteroids (equivalent to ≤ 10 mg of prednisone) and/or NSAIDs during the trial.
Croatian: Bolesnicima je tijekom ispitivanja bilo dopušteno istodobno primati stabilne doze metotreksata, niske doze kortikosteroida (ekvivalentne ≤ 10 mg prednizona) i/ili NSAIL-e.
English: In post-marketing experience, a case of fatal anaphylaxis following the first infusion of ORENCIA has been reported.
Croatian: Nakon stavljanja lijeka u promet prijavljen je slučaj anafilaksije sa smrtnim ishodom nakon prve infuzije lijeka ORENCIA.
English: Store unused syringes in the refrigerator in the original carton.
Croatian: Neupotrijebljene štrcaljke čuvajte u hladnjaku, u originalnom pakiranju.
English: The rate of progression of structural damage in year 2 was significantly lower than that in year 1 for patients randomised to abatacept (p < 0.0001).
Croatian: 4. Brzina napredovanja strukturnog oštećenja je za bolesnike randomizirane na abatacept bila značajno manja u 2. nego u 1. godini (p < 0,0001).
English: Summary of the safety profile in psoriatic arthritis
Croatian: Sažetak sigurnosnog profila kod psorijatičnog artritisa
English: Push DOWN on skin to unlock the Pen.
Croatian: PRITISNITE brizgalicu na kožu da biste je otključali.
English: 1 mL Fill line
Croatian: 1 ml Linija punjenja
English: If your injection is administered by a caregiver, this person must also handle the Pen carefully to prevent accidental needle stick injury and possibly spreading infection.
Croatian: Ako Vam injekciju daje skrbnik, on također mora pažljivo rukovati brizgalicom kako bi spriječio nehotičnu ozljedu iglom i mogući prijenos infekcije.