FrancophonIA/ELRC3.0 huggingface dataset:
English: Following subcutaneous administration of recommended doses, serum concentrations were maintained above 10 ng/ml for 8 to 16 hours.
Slovenian: Po subkutanem aplikaciji priporočenih odmerkov je bila koncentracija seruma naslednjih 8 do 16 ur višja od 10 ng/ml.
English: Among these, two cases of platelets < 50 x 109/l were reported and attributed to the leukapheresis procedure.
Slovenian: Med njimi so poročali o dveh primerih, pri katerih je bilo število trombocitov < 50 x 109/l, kar so pripisali postopku levkafereze.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Slovenian: Če vam je zdravnik povedal, da nekaterih sladkorjev ne prenašate, se pred uporabo zdravila posvetujte z vašim zdravnikom.
English: If you think you are having this type of reaction, stop your Filgrastim ratiopharm injection and get medical help immediately.
Slovenian: Če menite, da se je pri vas pojavila takšna reakcija, prenehajte z odmerjanjem zdravila Filgrastim ratiopharm in takoj poiščite zdravniško pomoč.
English: For storage conditions of the diluted medicinal product, see section 6.3.
Slovenian: Pogoji hranjenja razredčenih zdravil so opisani v poglavju 6.3.
English: In some disease types however, longer treatment lasting up to about one month may be required.
Slovenian: Pri nekaterih vrstah obolenj pa je potrebno tudi daljše zdravljenje, ki
English: The MAH must ensure that the system of pharmacovigilance, as described in version 2.1 presented in Module 1.8.1. of the Marketing Authorisation Application, is in place and functioning before and whilst the product is on the market.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora poskrbeti za vzpostavitev sistema farmakovigilance, kot je opisan v različici 2.1 in predstavljen v modulu 1.8.1 vloge za pridobitev dovoljenja za promet z zdravilom, ki mora biti v veljavi tako preden gre zdravilo na trg kot tudi takrat, ko je zdravilo že na
English: Do not use Filgrastim ratiopharm if you notice it is cloudy or there are particles in it.
Slovenian: Ne uporabite zdravila Filgrastim ratiopharm, če opazite, da je motno ali da so v njem delci.
English: Filgrastim ratiopharm is indicated for the mobilisation of peripheral blood progenitor cells (PBPC).
Slovenian: Zdravilo Filgrastim ratiopharm se uporablja za zbiranje perifernih krvotvornih matičnih celic (PBPC).
English: The serum elimination half-life of filgrastim is approximately 3.5 hours, with a clearance rate of approximately 0.6 ml/min/kg.
Slovenian: Razpolovni eliminacijski čas odstranjevanja filgrastima iz telesa znaša približno 3,5 ur; očistek znaša približno 0,6 ml/min/kg.
English: There is no evidence that patients with HIV infection treated with filgrastim show an increase in HIV replication.
Slovenian: Ni dokazov, da bi pri bolnikih, okuženih s HIV, ki so prejemali filgrastim, prišlo do hitrejšega razmnoževanja virusa
English: A diagnosis of splenic rupture should be considered in donors and/or patients reporting left upper abdominal pain or shoulder tip pain.
Slovenian: Na diagnozo rupture vranice moramo biti pozorni pri darovalcih in/ali bolnikih, ki poročajo o bolečini v zgornjem levem delu
English: Prior to allogeneic PBPC transplantation, use of filgrastim for the mobilisation of PBPC in normal donors allows a collection of 4 x 106 CD34+ cells/kg recipient body weight in the majority of the donors after two leukaphereses.
Slovenian: Pred alogensko presaditvijo matičnih celic iz periferne krvi uporaba filgrastima za zbiranje matičnih celic pri običajnih darovalcih omogoča, da se zbere 4 x 106 CD34+ celic/kg telesne mase prejemnika pri večini darovalcev, ki so bili deležni dveh levkaferez.
English: Excipient: Each ml of solution contains 50 mg of sorbitol.
Slovenian: Pomožna snov: 1ml raztopine vsebuje 50 mg sorbitola.
English: You should watch for a temperature of 37.8 °C or above, chills or other signs of infection, such as a rash, sore throat, diarrhoea, ear-ache, difficult or painful breathing or problems such as cough or wheezing.
Slovenian: Bodite pozorni na telesno temperaturo 37,8 °C ali več, mrzlico ali druge znake okužbe, kot so izpuščaj, vneto grlo, diareja, bolečine v ušesu, težave ali bolečine pri dihanju ali druge težave kot npr. kašljanje, sopihanje.
English: Find a comfortable, well-lit place and put everything you need where you can reach them (the Filgrastim ratiopharm pre-filled syringe, alcohol wipes and the puncture-proof container).
Slovenian: Poiščite si udoben, dobro osvetljen prostor in si pripravite vse, kar boste potrebovali, tako da bo pri roki (z zdravilom Filgrastim ratiopharm napolnjeno injekcijsko brizgo, alkoholne krpice in
English: If more than one leukapheresis is required, particular attention should be paid to donors with platelets < 100 x 109/l prior to leukapheresis; in general apheresis should not be performed if platelets < 75 x 109/l.
Slovenian: Če je potrebna več kot ena levkafereza, je potrebno pred samim postopkom levkafereze posebno pozornost nameniti bolnikom, katerih število trombocitov je < 100 x 109/l; v splošnem levkafereze ne smemo izvesti, če je število trombocitov < 75 x 109/l.
English: Like all medicines, Filgrastim ratiopharm can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Filgrastim ratiopharm neželene učinke, ki pa se ne pojavijo
English: These symptoms could be signs of severe pulmonary side effects, like pneumonia and respiratory distress syndrome in adults, which may be fatal.
Slovenian: Ti simptomi so lahko znaki resnih neželenih učinkov obolenja pljuč, kot sta pljučnica in sindrom dihalne stiske pri odraslih, ki sta lahko usodna.
English: This section contains information on how to give yourself an injection of Filgrastim ratiopharm.
Slovenian: To poglavje vsebuje podatke o tem, kako si sami injicirate zdravilo Filgrastim ratiopharm.
English: PARTICULARS TO APPEAR ON THE INTERMEDIATE PACKAGING Multipack Carton - Without the Blue Box
Slovenian: PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA VMESNI OVOJNINI Skupno pakiranje - brez podatkov »Blue Box«
English: Filgrastim ratiopharm is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 x 109/l) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate.
Slovenian: Zdravilo Filgrastim ratiopharm se uporablja za zdravljenje dolgotrajne nevtropenije (ANC manjše ali enako 1,0 × 109/l ) pri bolnikih z napredovalo okužbo HIV, z namenom zmanjšanja tveganja bakterijskih okužb, ko druge oblike zdravljenja nevtropenije niso primerne.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Outer Wrapper Label on Multipacks Wrapped in Transparent Foil - Including the Blue Box
Slovenian: Nalepka na zunanji ovojnini skupnih pakiranj, ovitih v prozorno folijo - vključno s podatki »Blue Box«
English: Filgrastim ratiopharm has not been tested in pregnant women.
Slovenian: Zdravila Filgrastim ratiopharm pri nosečnicah niso preizkusili.
English: If you stop using Filgrastim ratiopharm Before you stop using Filgrastim ratiopharm, talk to your doctor.
Slovenian: Če ste prenehali uporabljati zdravilo Filgrastim ratiopharm Preden prenehate uporabljati zdravilo Filgrastim ratiopharm se pogovorite z vašim zdravnikom.
English: If you forget to use Filgrastim ratiopharm Do not use a double dose to make up for a forgotten injection.
Slovenian: Če ste pozabili uporabiti zdravilo Filgrastim ratiopharm Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: It is also important that you dispose of the syringe in a puncture-proof container.
Slovenian: Prav tako je pomembno, da uporabljeno injekcijsko brizgo odložite v vsebnik, odporen na vbode.
English: What should I do before I give myself a subcutaneous injection of Filgrastim ratiopharm?
Slovenian: Kaj moram narediti, preden si dam subkutano injekcijo zdravila Filgrastim ratiopharm?
English: Infections and malignancies causing myelosuppression Neutropenia may be due to bone marrow infiltrating opportunistic infections such as Mycobacterium avium complex or malignancies such as lymphoma.
Slovenian: Okužbe in maligna obolenja, ki povzročajo mielosupresijo Nevtropenija je lahko posledica infiltracije kostnega mozga z oportunistično okužbo z Mycobacterium avium kompleksom ali maligno boleznijo, kot je limfom.
English: Filgrastim should not be used to increase the dose of cytotoxic chemotherapy beyond established
Slovenian: Filgrastima ne smete uporabljati za povečanje odmerka citotoksične kemoterapije izven uveljavljenih
English: The MAH commits to performing the studies and additional pharmacovigilance activities detailed in the Pharmacovigilance Plan, as agreed in version 5 of the Risk Management Plan (RMP) presented in Module 1.8.2. of the Marketing Authorisation Application and any subsequent updates of the RMP
Slovenian: Imetnik dovoljenja za promet z zdravilom se zaveže, da bo izvedel raziskave in dodatne dejavnosti s področja farmakovigilance, kot je podrobno opisano v Načrtu farmakovigilance in dogovorjeno v 5. različici Načrta za upravljanje s tveganji, predstavljenega v modulu 1.8.2. vloge za pridobitev dovoljenja za promet z zdravilom.
English: In clinical trials, 97% of patients who responded had a complete response at doses of 2.4 MIU (24 μg)/kg/day.
Slovenian: V kliničnih preskušanjih so pri 97% bolnikov, ki so se odzvali na zdravljenje, zabeležili popoln odgovor na odmerke v vrednosti 2,4 x 106i.e.
English: Multipack comprising 2 packs, each containing 5 pre-filled syringes.
Slovenian: Skupno pakiranje po 2 pakiranji, od katerih vsako vsebuje 5 napolnjenih injekcijskih brizg
English: As with other haematopoietic growth factors, G-CSF has shown in vitro stimulating properties on human endothelial cells.
Slovenian: Tako kot pri drugih hematopoetičnih rastnih faktorjih so tudi pri G-CSF pokazali, da in vitro spodbuja
English: In cancer patients, the pharmacokinetic profile of Filgrastim ratiopharm and the reference product was comparable after single and repeated subcutaneous administration.
Slovenian: Pri bolnikih z rakom sta bila farmakokinetična profila zdravila Filgrastim ratiopharm in referenčnega zdravila primerljiva po enkratnem in ponavljajočem odmerku, ki so ga bolniki prejeli po subkutani
English: Leukapheresis should be performed during the period when the ANC rises from < 0.5 x 109/l to > 5.0 x 109/l.
Slovenian: Levkafereze je potrebno izvesti v primeru, ko se absolutno število nevtrofilcev poveča iz < 0,5 x 109/l na > 5,0 x 109/l.
English: What Filgrastim ratiopharm looks like and contents of the pack Filgrastim ratiopharm is a solution for injection or infusion in a pre-filled syringe.
Slovenian: Izgled zdravila Filgrastim ratiopharm in vsebina pakiranja Zdravilo Filgrastim ratiopharm je raztopina za injiciranje ali infundiranje v napolnjeni injekcijski brizgi.
English: - transient low blood pressure, vascular disorders (which can cause pain, redness and swelling in
Slovenian: - prehoden nizek krvni tlak; žilne bolezni (zaradi katerih so vaše okončine lahko boleče, pordele
English: Take special care with Filgrastim ratiopharm - if you experience a cough, fever and difficulty breathing.
Slovenian: Bodite posebno pozorni pri uporabi zdravila Filgrastim ratiopharm - če začnete kašljati, se vam zviša telesna temperatura in se začnejo težave z dihanjem.
English: Dose reductions were noted to slow or stop the progression of splenic enlargement and in 3% of patients a splenectomy was required.
Slovenian: Nižji odmerki so upočasnili ali ustavili povečevanje vranice, pri 3% bolnikov pa je bila potrebna operativna odstranitev vranice.
English: Therefore, in patients with reduced precursors, neutrophil response may be diminished (such as those treated with extensive radiotherapy or chemotherapy, or those with bone marrow infiltration
Slovenian: Zaradi tega lahko pri bolnikih z zmanjšanim številom prekurzorjev pride tudi do manjšega odziva nevtrofilcev (kot npr. pri bolnikih, ki prejemajo dolgotrajno radioterapijo ali kemoterapijo, ali pri tistih, pri katerih je prišlo do infiltracije kostnega mozga s tumorjem).
English: Transient decreases in blood pressure, not requiring clinical treatment, have been reported
Slovenian: Občasno so poročali o prehodnem zvišanju krvnega tlaka; klinično zdravljenje ni bilo potrebno.
English: In clinical studies, > 90% of patients responded at these doses, achieving reversal of neutropenia in a median of 2 days.
Slovenian: V kliničnih preskušanjih se je več kot 90% bolnikov odzvalo na te odmerke, tako da so za ustavitev napredovanja nevtropenije v povprečju potrebovali 2 dni.
English: - Never put the syringes that you have used into your normal household rubbish bin.
Slovenian: - Uporabljenih brizg nikoli ne odložite v koš, ki ga uporabljate za odlaganje ostalih gospodinjskih
English: After dilution: Chemical and physical in-use stability of the diluted solution for infusion has been demonstrated for 24 hours at 2 °C to 8 °C.
Slovenian: Po redčenju: razredčena raztopina za infundiranje ostane kemično in fizikalno stabilna še 24 ur pri temperaturi od 2°C do 8 °C.
English: Patients who have undergone very extensive prior myelosuppressive therapy may not show sufficient mobilisation of PBPC to achieve the recommended minimum yield (2.0 x 106 CD34+ cells/kg) or acceleration of platelet recovery to the same degree.
Slovenian: Predhodno izpostavljanje citotoksičnim učinkovinam Pri bolniki, ki so bili predhodno izpostavljeni dolgotrajni mielosupresivni terapiji, se lahko zgodi, da ni bilo zbranih dovolj matičnih celic iz periferne krvi, da bi dosegli njihovo minimalno število (2,0 x 106 CD34+ celic/kg) ali pospešeno tvorjenje trombocitov v enaki meri.
English: - a puncture-proof container (plastic container provided by the hospital or pharmacy) so you can
Slovenian: - vsebnik, odporen na vbode (plastičen vsebnik, ki ga dobite v bolnišnici ali lekarni), tako da boste lahko varno odlagali uporabljene brizge.
English: Reversible, dose-dependent and usually mild or moderate elevations of lactate dehydrogenase (LDH), alkaline phosphatase, serum uric acid and gamma-glutamyltransferase (GGT) occurred with filgrastim in approximately 50%, 35%, 25%, and 10% of patients respectively, at recommended doses.
Slovenian: Reverzibilno, od odmerka odvisno blago do zmerno zvišanje laktatne dehidrogenaze (LDH), alkalne fosfataze, sečne kisline in gama-glutamiltransferaze (GGT) se je pojavilo pri 50%, 35%, 25% in 10% bolnikov, ki so prejemali filgrastim v priporočenem odmerku.
English: To give yourself a subcutaneous injection you will need: - a pre-filled syringe of Filgrastim ratiopharm,
Slovenian: Za subkutano samoinjiciranje boste potrebovali: - napolnjeno injekcijsko brizgo z zdravilom Filgrastim ratiopharm,
English: In addition, an updated RMP should be submitted
Slovenian: Posodobljen načrt za upravljanje s tveganji je potrebno predložiti tudi
English: You will need to have regular blood tests whilst being treated with Filgrastim ratiopharm to count the number of neutrophils and other white blood cells in your blood.
Slovenian: Med zdravljenjem z zdravilom Filgrastim ratiopharm vam bodo morali redno pregledovati kri, zato da naredijo analizo števila nevtrofilcev in drugih belih krvničk v vaši krvi.
English: Particular attention should be paid to haematological values
Slovenian: Pri tem je treba posebno pozornost nameniti hematološkim vrednostim in infekcijskim boleznim.
English: 0.2 ml of 200 mg/ml (20%) human albumin solution added.
Slovenian: (300 μg) dodati 0,2 ml 20% raztopine humanega albumina.
English: - if you have sickle cell disease; or
Slovenian: - če imate srpasto anemijo ali
English: There were no relevant differences between Filgrastim ratiopharm and the reference product with regard to duration of severe neutropenia and incidence of febrile neutropenia.
Slovenian: Med zdravilom Filgrastim ratiopharm in referenčnim zdravilom ni bilo očitne razlike v zvezi s trajanjem hude nevtropenije in nastanka febrilne nevtropenije.
English: Risks associated with increased doses of chemotherapy Special caution should be used when treating patients with high dose chemotherapy because improved tumour outcome has not been demonstrated and intensified doses of chemotherapeutic agents may lead to increased toxicities including cardiac, pulmonary, neurologic and dermatologic effects (please refer to the Summary of Product Characteristics of the specific chemotherapy agents used).
Slovenian: Tveganja, povezana z zvečanimi odmerki kemoterapije Še posebej pozorni moramo biti pri zdravljenju bolnikov z visokimi odmerki kemoterapije, ker pozitivni učinki kemoterapije na rast tumorja še niso vidni, saj lahko zvečani odmerki kemoterapevtskih učinkovin povzročijo povečano toksičnost, le-ta pa vpliva na srce, pljuča, živčevje in kožo (obrnite se na Povzetek glavnih značilnosti zdravila posameznih kemoterapevtskih učinkovin).
English: Undesirable effects possibly related to filgrastim therapy and typically occurring in < 2% of SCN patients were injection site reaction, headache, hepatomegaly, arthralgia, alopecia, osteoporosis and
Slovenian: Neželeni učinki, najverjetneje povezani s terapijo s filgrastimom, ki so se značilno pojavili pri < 2% bolnikov, so vključevali reakcijo na mestu aplikacije, glavobol, hepatomegalijo, artralgijo, alopecijo
English: Special precautions in patients with acute myeloid leukaemia
Slovenian: Posebni ukrepi pri bolnikih z akutno mieolično levkemijo
English: cannot be estimated from the available data
Slovenian: iz razpoložljivih podatkov pogostnosti ni mogoče oceniti
English: The safety and efficacy of filgrastim have not been assessed in normal donors < 16 years or > 60
Slovenian: Varnost in učinkovitost zdravila filgrastim pri običajnih darovalcih, mlajših od 16 let ali starejših od 60. let, nista bili ocenjeni.
English: The safety and efficacy in neonates and patients with autoimmune neutropenia have not been
Slovenian: Varnost in učinkovitost pri novorojenčkih in bolnikih z avtoimuno nevtropenijo nista bili ugotovljeni.
English: One retrospective European study evaluating the use of G-CSF after allogeneic bone marrow transplantation in patients with acute leukaemias suggested an increase in the risk of GvHD, treatment related mortality (TRM) and mortality when G-CSF was administered.
Slovenian: Ena retrospektivna evropska študija, v kateri so ocenili uporabo G-CSF po alogenski presaditvi kostnega mozga pri bolnikih z akutno levkemijo, je pokazala zvišanje tveganja za GvHD, z zdravljenjem povezano smrtnostjo (TRM - treatment related mortality)in smrtnost pri uporabi G-CSF.
English: For patients treated with filgrastim diluted to concentrations below 1.5 MIU (15 μg) per ml, human serum albumin (HSA) should be added to a final concentration of 2 mg/ml.
Slovenian: Pri bolnikih, ki prejemajo zdravilo filgrastim v koncentraciji, ki je nižja od 1,5 x 106 i.e. (15 μg) na ml, morate končni koncentraciji 2 mg/ml dodati še raztopino humanega albumina (»human serum
English: The most frequent undesirable effects attributable to filgrastim were bone pain, and general
Slovenian: Najbolj pogosti neželeni učinki, povezani s filgrastimom, so zajemali bolečino v kosteh ter splošno
English: Leukocytosis (WBC > 50 x 109/l) was observed in 41% of donors and transient thrombocytopenia (platelets < 100 x 109/l) following filgrastim and leukapheresis was observed in 35% of donors.
Slovenian: Levkocitozo (število belih krvničk > 50 x 109/l) so opazili pri 41% darovalcev, prehodno trombocitopenijo (število trombocitov < 100 x 109/l) pa pri 35% darovalcev po odmerjanju filgrastima in po levkaferezi.
English: Filgrastim ratiopharm containing r-metHuG-CSF (filgrastim) causes marked increases in peripheral blood neutrophil counts within 24 hours, with minor increases in monocytes.
Slovenian: Zdravilo Filgrastim ratiopharm, ki vsebuje rekombinantni človeški G-CSF (filgrastim) v 24-ih urah povzroči izrazito zvišanje števila nevtrofilcev v periferni krvi, medtem ko je zvišanje monocitov manjše.
English: Your doctor will tell you why you are being treated with Filgrastim ratiopharm.
Slovenian: Prav tako vam bo zdravnik razložil, zakaj se zdravite z zdravilom Filgrastim ratiopharm.
English: THE FOLLOWING INFORMATION IS INTENDED FOR MEDICAL OR HEALTHCARE
Slovenian: SPODNJI PODATKI SO NAMENJENI IZKLJUČNO STROKOVNIM ZDRAVSTVENIM
English: The amount of Filgrastim ratiopharm you need will depend on the condition you are taking Filgrastim ratiopharm for and on your bodyweight.
Slovenian: Količina zdravila Filgrastim ratiopharm, ki jo potrebujete, je odvisna od stanja, zaradi katerega morate jemati zdravilo, in od vaše telesne mase.
English: In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 x 109/l, and a history of severe or recurrent infections, long term administration of Filgrastim ratiopharm is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.
Slovenian: Bolnikom, otrokom ali odraslim s hujšo obliko kongenitalne, ciklične ali idiopatične nevtropenije z absolutnim številom nevtrofilcev (ANC) ≤ 0,5 × 109/l in s hujšimi ali ponavljajočimi se okužbami, se dolgotrajno jemanje zdravila Filgrastim ratiopharm predpiše zato, da se poveča število nevtrofilcev in zmanjša pogostost nastanka in trajanja z okužbami povezanih pojavov.
English: Check again to make sure the correct dose of Filgrastim ratiopharm is in the syringe.
Slovenian: Še enkrat preverite, če je v brizgi ustrezen odmerek zdravila Filgrastim ratiopharm.
English: A subset of approximately 12% of patients who had normal cytogenetic evaluations at baseline were subsequently found to have abnormalities, including monosomy 7, on routine repeat evaluation.
Slovenian: Pri manjšem številu, in sicer pri 12% bolnikov, katerih rezultati citogenetskih preiskav so bili sicer normalni, pa so pri rutinskih ponavljajočih se pregledih opazili nepravilnosti, vključno z monosomijo 7.
English: There are no adequate data from the use of filgrastim in pregnant women.
Slovenian: O uporabi zdravila filgrastim pri nosečnicah ni zadostnih podatkov.
English: Filgrastim ratiopharm is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia.
Slovenian: Zdravilo Filgrastim ratiopharm se uporablja za skrajšanje trajanja nevtropenije in v primeru nastanka febrilne nevtropenije pri bolnikih, ki prejemajo citotoksično kemoterapijo za maligne tvorbe (z izjemo kronične mieloične levkemije in mielodisplastičnih sindromov), ter za skrajšanje trajanja nevtropenije pri bolnikih, ki se zdravijo z mieloablativno terapijo po presaditvi kostnega mozga, pri katerih obstaja povečano tveganje za dlje trajajočo hudo nevtropenijo.
English: Check the appearance of Filgrastim ratiopharm.
Slovenian: Preverite videz raztopine Filgrastim ratiopharma.
English: - inflammation of blood vessels, often with skin rash (very rare); the appearance of plumcoloured, raised, painful lesions on the limbs (sometimes the face and neck) with fever (Sweet's syndrome, very rare); hair loss; pain at the site of injection; rash joint pain; chest pain; worsening of rheumatic conditions; loss of calcium from the bones; pain and swelling of the joints, similar to gout (frequency unknown) - fatigue, generalised weakness, unspecified pain.
Slovenian: - vnetje krvnih žil, ki ga običajno spremlja izpuščaj na koži (zelo redko); pojav temno vijoličnih, dvignjenih in bolečih ran na okončinah (včasih tudi na obrazu in vratu) s povišano telesno temperaturo (Sweetov sindrom; zelo redko); izpadanje las; bolečina na mestu vboda; izpuščaj - bolečine v sklepih; bolečina v prsih; poslabšanje revmatičnega stanja; izguba kalcija v kosteh; bolečina in oteklost sklepov, podobna protinu (pogostnost neznana) - utrujenost, splošna oslabelost, nespecifična bolečina