FrancophonIA/ELRC3.0 huggingface dataset:
English: Betmiga has not been studied in patients with end stage renal disease (GFR < 15 mL/min/1.73 m2 or patients requiring haemodialysis) and, therefore, it is not recommended for use in this patient population.
Maltese: Betmiga ma ġiex studjat għall-pazjenti b'mard renali fl-aħħar stadju (GFR < 15 mL/min/1.73 m2 jew pazjenti li jeħtieġu l-emodijalisi) u, għaldaqstant, mhuwiex rakkomandat li jintuża minn din il popolazzjoni ta' pazjenti.
English: The most serious side effects may include irregular heart beat (atrial fibrillation).
Maltese: L-aktar effetti sekondarji serji jistgħu jinkludu taħbit tal-qalb irregolari (fibrillazzjoni tal-atriju).
English: Apealea (paclitaxel)
Maltese: Apealea (paklitaksel)
English: Further information on Apealea can be found on the Agency's website: ema.europa.eu/medicines/human/EPAR/apealea.
Maltese: Aktar informazzjoni dwar Apealea tinstab fis-sit elettroniku tal-Aġenzija ema.europa.eu/medicines/human/EPAR/apealea.
English: Apealea (paclitaxel) EMA/791927/2018
Maltese: Apealea (paklitaksel) EMA/653818/2018
English: Other information about Apealea
Maltese: Informazzjoni oħra dwar Apealea
English: Apealea contains the active substance paclitaxel.
Maltese: Apealea fih is-sustanza attiva paklitaksel.
English: The most common side effects with Apealea (which may affect more than 1 in 10 people) are neutropenia (low numbers of white blood cells called neutrophils), stomach and gut disorders such as diarrhoea, nausea (feeling sick) and vomiting, peripheral neuropathy (nerve damage in hands and feet), joint and muscle pain, and reactions such as redness, soreness and inflammation of the veins at the site of infusion.
Maltese: L-effetti sekondarji l-aktar komuni bl-Apealea (li jistgħu jaffettwaw aktar minn persuna 1 minn kull 10) huma n-newtropenija (għadd baxx ta' ċelloli bojod tad-demm li jissejħu newtrofili), disturbi tal-istonku u tal-imsaren bħad-dijarea, nawżja (tħossok ma tiflaħx) u remettar, newropatija periferali (ħsara finnervituri fl-idejn u s-saqajn), uġigħ fil-ġogi u fil-muskoli, u reazzjonijiet bħal ħmura, uġigħ u infjammazzjoni tal-vini fis-sit tal-infużjoni.
English: Supportive data from the study showed that the average time that patients lived after treatment was 25.7 months among those given Apealea and 24.8 months for those given conventional paclitaxel.
Maltese: 7 xahar fost dawk li ngħataw Apealea u 24.8 xahar għal dawk li ngħataw il-paklitaksel konvenzjonali.
English: Patients are also treated with a platinum-based medicine, carboplatin.
Maltese: Il-pazjenti jiġu kkurati wkoll b'mediċina bbażata fuq il-platinu, karboplatin.
English: Apealea has been shown to be as effective as a conventional formulation of paclitaxel in one main study involving further treatment of 789 women whose ovarian, fallopian tube or peritoneal cancer had come back.
Maltese: Apealea wera li huwa effettiv daqs il-formulazzjoni konvenzjonali ta' paklitaksel fi studju wieħed ewlieni li kien jinvolvi kura ulterjuri ta' 789 mara li l-kanċer tal-ovarji, tat-tubu fallopjan jew peritoneali kien reġa' tfaċċa.
English: The dose of Apealea is 250 mg per square metre (calculated based on height and body weight) and is given by infusion over about 1 hour, once every 3 weeks, for 6 cycles of treatment.
Maltese: Id-doża ta' Apealea hija 250 mg għal kull metru kwadru (ikkalkulata skond it-tul u l-piż tal-ġisem) u tingħata b'infużjoni għal madwar 1 siegħa, darba kull 3 ġimgħat għal 6 ċikli ta' kura.
English: Apealea is available as a powder to make up a solution for infusion (drip) into a vein.
Maltese: Apealea jiġi bħala trab li jsir soluzzjoni għall-infużjoni (dripp) ġol-vina.
English: What are the risks associated with Apealea?
Maltese: X'inhuma r-riskji assoċjati ma' Apealea?
English: As for all medicines, data on the use of Apealea are continuously monitored.
Maltese: Bħal fil-każ tal-mediċini kollha, id-data dwar l-użu ta' Apealea hija ssorveljata kontinwament.
English: Apealea is a cancer medicine used to treat women with cancer of the ovary or surrounding structures (the fallopian tube that connects the ovary to the womb, or the peritoneum, the membrane that lines the abdomen).
Maltese: Apealea huwa mediċina kontra l-kanċer li tintuża biex tikkura nisa bil-kanċer tal-ovarji jew tal-istrutturi tal-madwar (it-tubu fallopjan li jgħaqqad l-ovarji mal-ġuf, jew il-peritoneum, ir-rita tal-membrana taladdome).
English: Why is Apealea authorised in the EU?
Maltese: Għaliex Apealea huwa awtorizzat fl-UE?
English: Apealea is given along with a platinum-based medicine, carboplatin, to patients whose disease responds to platinum-based cancer medicines and has come back after initial treatment.
Maltese: Apealea jingħata flimkien ma' mediċina bbażata fuq il-platinu, karboplatin, lil pazjenti li l-marda tagħhom tirreaġixxi għal mediċini kontra l-kanċer ibbażati fuq il-platinu u li reġgħet tfaċċat wara l-kura inizjali.
English: The European Medicines Agency considered that Apealea was as effective as conventional paclitaxel, and could be a valuable alternative in combination with carboplatin.
Maltese: L-Aġenzija Ewropea għall-Mediċini kkunsidrat li l-Apealea kien effettiv daqs il-paklitaksel konvenzjonali, u jista' jkun alternattiva siewja f'kombinazzjoni ma' karboplatin.
English: The active substance in Apealea, paclitaxel, is a cancer medicine that has been used in the EU for many years.
Maltese: Is-sustanza attiva f'Apealea, il-paklitaksel, hija mediċina kontra l-kanċer li ilha tintuża fl-UE għal ħafna snin.
English: How does Apealea work?
Maltese: Kif jintuża Apealea?
English: It belongs to the group of cancer medicines known as the ‘taxanes'.
Maltese: Din tappartjeni għall-grupp ta' mediċini kontra l-kanċer magħruf bħala ‘tassani'.
English: The paclitaxel in Apealea is formulated in tiny particles, called micelles, to help it dissolve in the infusion solvent.
Maltese: Il-paklitaksel f'Apealea tiġi fformolata f'partiċelli żgħar, imsejħa miċelli, biex jgħinuha tinħall fis-solvent tal-infużjoni
English: How is Apealea used?
Maltese: Kif jaħdem Apealea?
English: Paclitaxel blocks a
Maltese: 1 xhur b'paklitaksel konvenzjonali.
English: What measures are being taken to ensure the safe and effective use of Apealea?
Maltese: X'miżuri qegħdin jittieħdu biex jiġi żgurat l-użu sigur u effettiv ta' Apealea?
English: While the new formulation might be associated with more infusion site reactions, and studies suggested stronger effects on blood cells and the gut, these were considered manageable and the overall benefits and risks are consistent with those of other paclitaxel medicines.
Maltese: Filwaqt li l-formulazzjoni l-ġdida tista' tkun assoċjata ma' aktar reazzjonijiet fis-sit tal-infużjoni, u l-istudji ssuġġerew effetti aktar b'saħħithom fuq iċ-ċelloli tad-demm u l-musrana, dawn kienu kkunsidrati maniġġabbli u l-benefiċċji u r-riskji ġenerali huma konsistenti ma' dawk ta' mediċini paklitaksel oħrajn.
English: The medicine can only be obtained with a prescription and should be given under the supervision of a specialist in the treatment of cancer.
Maltese: Ma għandux jiġi sostitwit b'mediċini oħra li fihom il-paklitaksel.
English: Patients also received a platinum-based cancer medicine, carboplatin.
Maltese: Il-pazjenti rċevew ukoll mediċina tal-kanċer ibbażata fuq il-platinu, karboplatin.
English: For the full list of side effects of Apealea, see the package leaflet.
Maltese: Għal-lista sħiħa tal-effetti sekondarji ta' Apealea, ara lfuljett ta' tagħrif.
English: Doses may be delayed or reduced by the doctor, or treatment may be stopped, if severe side effects occur; doses should also be reduced in patients with moderate or severe reduction in liver function.
Maltese: L-effetti sekondarji rrappurtati b'Apealea huma evalwati bir-reqqa u kull azzjoni meħtieġa hi meħuda biex tipproteġi lill-pazjenti.
English: Solvent: 35 ml
Maltese: 35ml
English: -1 Live avian infectious bronchitis virus, strain D388: 104.0 - 105.5 EID50*/dose * 50% egg infective dose
Maltese: -1 Virus ħaj tal-bronkite infettiva tat-tjur, strejn D388: 104.0 - 105.
English: Solvent: vial (LDPE)
Maltese: ku njett (LDPE)
English: EMA/483954/2014
Maltese: EU/2/14/174/003
English: Chicken Oculonasal use Lyophilisate: cup (Alu/PP);
Maltese: Lajofiliżejt: tazza(Alu/P P)
English: -1 Lyophilisate and solvent for oculonasal suspension
Maltese: Lajofiliżejt u solvent għall-għ għallgħajnejn/mnifse jn għallsuspensjoni
English: 10 lyophilisate cups + 10 solvent vials
Maltese: Tazzi tallajofiliżejt kunjetti tassolvent
English: Target species
Maltese: Lajofiliżejt doża
English: EMA/475324/2015 EMEA/H/C/000436
Maltese: EMEA/H/C/000436
English: It is available as tablets (2.5, 5, 10 and 20 mg).
Maltese: Jiġi bħala pilloli (2.5, 5, 10 u 20 mg).
English: The full EPAR for Cialis can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Maltese: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom medicine should be taken around the same time every day and the appropriateness of the once-a-day dosing should be re-assessed regularly.
Maltese: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom istess ħin kuljum u trid issir valutazzjoni ripetuta regolari ta' kemm hu xieraq li titkompla d-doża ta' darba kuljum.
English: The active substance of Cialis, tadalafil, belongs to a group of medicines called 'phosphodiesterase type 5 (PDE5) inhibitors'.
Maltese: Is-sustanza attiva ta' Cialis, it-tadalafil, hi parti minn grupp ta' mediċini magħruf bħala 'inibituri talfosfodjesterażi tat-tip 5 (PDE5)' (phosphodiesterase type 5 inhibitors).
English: However, sexual stimulation is still needed.
Maltese: Madankollu xorta tinħtieġ stimulazzjoni sesswali.
English: This summary was last updated in 07-2015.
Maltese: Dan is-sommarju ġie aġġornat l-aħħar f'07-2015.
English: Cialis is a medicine containing the active substance tadalafil.
Maltese: Cialis huwa mediċina li fiha s-sustanza attiva tadalafil.
English: This is a summary of the European public assessment report (EPAR) for Cialis.
Maltese: Dan id-dokument huwa sommarju tar-rapport pubbliku Ewropew ta' valutazzjoni (EPAR) għal Cialis.
English: For treating erectile dysfunction, the recommended dose of Cialis is 10 mg taken ‘on demand' at least 30 minutes before sexual activity.
Maltese: Għall-kura ta' disfunzjoni erettili, id-doża rakkomandata ta' Cialis hija ta' 10 mg meħuda ‘skont ilbżonn' mill-inqas 30 minuta qabel l-attività sesswali.
English: Once-a-day dosing of Cialis was studied in three further studies lasting 12 to 24 weeks and involving a total of 853 patients.
Maltese: L-għoti ta' doża ta' Cialis darba kuljum ġiet studjata fi tliet studji oħra li damu bejn 12 u 24 ġimgħa u li fihom b'kollox ħadu sehem 853 pazjent.
English: Overall, in the studies of general populations, 81% of patients reported that Cialis ‘on demand' improved their erections as compared to 35% of those taking placebo.
Maltese: Globalment, fl-istudji fil-popolazzjonijiet ġenerali, 81% tal-pazjenti rrappurtaw li Cialis meħud‘ skont il-bżonn' tejjeb l-erezzjoni jiet meta mqabbla ma' 35% ta' dawk ikkurati bil-plaċebo.
English: Cialis, when taken ‘on demand' before sexual activity, has been studied in six main studies including 1,328 patients with erectile dysfunction.
Maltese: Cialis, meħud ‘skont il-bżonn' qabel l-attività sesswali, ġie studjat f'sitt studji ewlenin li fihom ħadu sehem 1,328 pazjent li jbatu minn disfunzjoni erettili.
English: For one of the questionnaires, where the maximum score is 30, patients who recorded scores of about 15 before treatment, recorded scores of 22.6 or 25 after receiving Cialis 10 mg or 20 mg, respectively.
Maltese: F'wieħed millkwestjonarji, li fih il-punteġġ massimu kien 30, il-pazjenti li rreġistraw punteġġi ta' madwar 15 qabel ilkura, wara li ħadu Cialis, b'doża ta' 10 mg jew 20 mg, irreġistraw punteġġi ta' 22.6 jew 25, rispettivament.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Cialis on 12 November 2002.
Maltese: Il-Kummissjoni Ewropea tat awtorizzazzjoni għat-tqegħid fis-suq għal Cialis valida fl-Unjoni Ewropea kollha fit-12 ta' Novembru 2002.
English: The dose is 5 mg once a day, but can be lowered to 2.5 mg once a day depending on how well it is tolerated.
Maltese: Id-doża hi 5 mg darba kuljum, iżda tista' titnaqqas għal 2.5 mg darba kuljum skont kemm tkun tollerata tajjeb.
English: Once-a-day dosing is not recommended in patients with severe kidney problems, and should only be prescribed to patients with liver problems after a careful evaluation of the benefits and risks of taking the medicine.
Maltese: Id-doża ta' darba kuljum mhix rakkomandata għal pazjenti li jbatu minn problemi gravi fil-kliewi, u għal pazjenti li jbatu minn problemi fil-fwied għandha tiġi preskritta biss wara evalwazzjoni bir-reqqa tal-benefiċċji u r-riskji tat-teħid tal-mediċina.
English: What is Cialis?
Maltese: X'inhu Cialis?
English: Why has Cialis been approved?
Maltese: Għaliex ġie approvat Cialis?
English: During normal sexual stimulation, cGMP is produced in the penis, where it causes the muscle in the spongy tissue of the penis (the corpora cavernosa) to relax, allowing the flow of blood into the corpora, producing the erection.
Maltese: Waqt stimulazzjoni sesswali normali, il-pene jipproduċi s-cGMP u jwassal għar-rilassament talmuskolatura tat-tessut artab tal-pene (il-corpora cavernosa), li jippermetti l-fluss tad-demm filcorpora, u b'hekk jipproduċi l-erezzjoni.
English: Cialis can also be used in men to treat the signs and symptoms of benign prostatic hyperplasia (enlarged prostate gland that is not cancerous), which involve problems with the flow of urine.
Maltese: Cialis jista' jintuża wkoll f'irġiel għall-kura tas-sinjali u s-sintomi ta' iperplasija prostatika beninja (tkabbir tal-glandola tal-prostata li mhix kanċeroġeni), li toħloq problemi bil-fluss tal-urina.
English: How has Cialis been studied?
Maltese: Kif ġie studjat Cialis?
English: What is the risk associated with Cialis?
Maltese: X'inhu r-riskju assoċjat ma' Cialis?
English: Cialis given at a dose of 5 mg was also more effective than placebo in all the studies in patients with benign prostatic hyperplasia, with the results showing a significant improvement in symptoms after 12 weeks compared with placebo.
Maltese: Cialis meħud f'doża ta' 5 mg kien ukoll iktar effettiv mill-plaċebo fl-istudji kollha f'pazjenti li kienu qed ibatu b'iperplasija prostatika beninja, bir-riżultati juru titjib sinifikanti fis-sintomi wara 12-il ġimgħa meta mqabbla mal-plaċebo.
English: Four main studies comparing Cialis with placebo were carried out in 1,500 patients with the condition, including some who also had erectile dysfunction.
Maltese: Saru erba' studji ewlenin li jqabblu Cialis ma' plaċebo li fihom ħadu sehem 1,500 pazjenti bil-kondizzjoni, inklużi xi wħud li jbatu wkoll minn disfunzjoni erettili.
English: This may reduce the problems with the flow of urine which are symptoms of benign prostatic hyperplasia.
Maltese: Dan jista' jnaqqas il-problemi bil-fluss tal-urina li huma sintomi ta' iperplasija prostatika beninja.
English: The dose may be increased to 20 mg for men who do not respond to the 10 mg dose.
Maltese: Id-doża tista' tiżdied għal 20 mg għal irġiel li ma jirrispondux għad-doża ta' 10 mg.
English: For the full list of all side effects reported with Cialis, see the package leaflet.
Maltese: Għal-lista sħiħa taleffetti sekondarji rrappurtati b'Cialis, ara l-fuljett ta' tagħrif.
English: The most common side effects with Cialis are headache, dyspepsia (indigestion), back pain and myalgia (muscle pain), which are more common at higher doses.
Maltese: L-effetti sekondarji l-aktar komuni b'Cialis huma wġigħ ta' ras, dispepsija (indiġestjoni), uġigħ fiddahar u mijalġija (uġigħ fil-muskoli), li huma aktar komuni b'dożi aktar għoljin.
English: Cialis must not be taken with nitrates (a type of medicine used for angina) or medicines of the class ‘guanylate cyclase stimulators' such as riociguat (a medicine for high blood pressure in the vessels supplying the lungs, known as pulmonary hypertension).
Maltese: Lanqas ma għandu jintuża minn pazjenti li xi darba sofrew minn telf tal-vista minħabba xi problema fiċ-ċirkolazzjoni tad-demm lejn in-nervitura tal-għajn (newropatija ottika iskemika anterjuri mhux arteritika, NAION). Cialis m'għandux jittieħed man-nitrati (tip ta' mediċina użata għall-kura tal-anġina) jew mediċini tal-klassi 'guanylate cyclase stimulators' bħal riociguat (mediċina għall-pressjoni tad-demm għolja fil-vażijiet li jgħaddu d-demm lill-pulmuni, magħrufa bħala ipertensjoni pulmonari).
English: Patients taking Cialis once a day at doses of 2.5 or 5 mg also reported improved erections compared with those taking placebo.
Maltese: Ilpazjenti li kienu qed jieħdu Cialis darba kuljum f'dożi ta' 2.5 jew 5 mg ukoll irrappurtaw titjib flerezzjoni meta mqabbla ma' dawk ikkurati bil-plaċebo.
English: For Cialis to be effective in this condition, sexual stimulation is required.
Maltese: Biex Cialis ikollu effett f'din il-kondizzjoni, teħtieġ stimulazzjoni sesswali.
English: The maximum recommended dosing frequency is once per day, but continuous daily use of 10 or 20 mg Cialis is not recommended.
Maltese: Il-frekwenza massima rakkomandata tad-dożaġġ hi darba kuljum, iżda l-użu kontinwu ta' Cialis, kemm b'doża ta' 10 mg kif ukoll 20 mg, kuljum mhux rakkomandat.
English: Cialis is used to treat men with erectile dysfunction (sometimes called impotence) when they cannot get, or keep, a hard penis (erection) sufficient for satisfactory sexual activity.
Maltese: Cialis jintuża għall-kura ta' rġiel b'disfunzjoni erettili (imsejħa wkoll impotenza) li tikkonsisti millinkapaċità li tintlaħaq u tinżamm erezzjoni suffiċjenti għal attività sesswali sodisfaċenti.
English: For treating men with benign prostatic hyperplasia, or men with both benign prostatic hyperplasia and erectile dysfunction, the recommended dose is 5 mg once a day.
Maltese: Għall-kura ta' rġiel li jbatu minn iperplasija prostatika beninja, jew irġiel li jbatu kemm minn iperplasija prostatika beninja kif ukoll minn disfunzjoni erettili, id-doża rakkomandata hija ta' 5 mg darba kuljum.
English: Cialis was significantly more effective than placebo in all studies in erectile dysfunction.
Maltese: Cialis kien ferm iktar effikaċi mill-plaċebo fl-istudji kollha ta' disfunzjoni erettili.
English: Other information about Trevaclyn:
Maltese: Informazzjoni oħra dwar Trevaclyn:
English: This summary was last updated in 05-2008.
Maltese: Dan is-sommarju ġie aġġornat l-aħħar fi 05-2008.
English: EUROPEAN PUBLIC ASSESSMENT REPORT (EPAR) TREVACLYN EPAR summary for the public
Maltese: RAPPORT TA' VALUTAZZJONI PUBBLIKA EWROPEW (EPAR) TREVACLYN Sommarju ta' l-EPAR għall-pubbliku
English: The second study showed that the LDL cholesterol levels were further reduced when Trevaclyn was taken with simvastatin (48% reduction), compared with Trevaclyn alone (17% reduction) or simvastatin alone (37% reduction).
Maltese: It-tieni studju wera li l-livelli ta' kolesterol LDL tnaqqsu iktar meta Trevaclyn ittieħed flimkien ma' simvastatin (tnaqqis ta' 48%), milli meta Trevaclyn ittieħed waħdu (tnaqqis ta' 17%) jew ma' simvastatin waħdu (tnaqqis ta' 37%).
English: The first study compared the effectiveness of Trevaclyn with that of nicotinic acid alone or placebo (a dummy treatment) in reducing the levels of LDL cholesterol in a total of 1,613 patients.
Maltese: Lewwel studju qabbel l-effikaċja ta' Trevaclyn ma' dik ta' l-aċidu nikotiniku jew plaċebo (trattament finta) fit-tnaqqis tal-livelli ta' kolesterol LDL f'total ta' 1,613-il pazjent.
English: The two active substances in Trevaclyn, nicotinic acid and laropiprant, have different modes of action.
Maltese: Iż-żewġ sustanzi attivi fi Trevaclyn, l-aċidu nikotiniku u laropiprant, għandhom modi differenti ta' azzjoni.
English: The second study compared the combination of Trevaclyn and simvastatin (a statin) with Trevaclyn alone or simvastatin alone in 1,398 patients.
Maltese: It-tieni studju qabbel il-kombinazzjoni ta' Trevaclyn u simvastatin (statin) ma' Trevaclyn waħdu jew simvastatin waħdu f'1,398 pazjent.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Trevaclyn to Merck Sharp & Dohme Ltd. on 3 July 2008.
Maltese: Il-Kummissjoni Ewropea tat awtorizzazzjoni għat-tqegħid fis-suq madwar l-Unjoni Ewropea, għal Trevaclyn lil Merck Sharp & Dohme Ltd. fl-3 ta' Lulju 2008.
English: In the first study, LDL cholesterol levels were reduced by 19% in patients taking Trevaclyn, compared with 1% in those taking placebo.
Maltese: Fl-ewwel studju, il-livelli ta' kolesterol LDL tnaqqsu b'19% fil-pazjenti li kienu qed jieħdu Trevaclyn, meta mqabbla ma' 1% f'dawk li kienu qed jieħdu plaċebo.
English: What is Trevaclyn?
Maltese: X'inhu Trevaclyn?
English: Patients with combined mixed dyslipidaemia have high blood levels of ‘bad' LDL cholesterol and triglycerides (a type of fat), and low levels of ‘good' HDL cholesterol.
Maltese: Il-pazjenti b'dislipidemja mħallta kombinata jkollhom livelli għoljin ta' kolesterol LDL ‘ħażin' u ta' triġliċeridi (tip ta' xaħam), u livelli baxxi ta' kolesterol HDL ‘tajjeb' fiddemm.
English: Trevaclyn is normally given together with a statin (the standard medicine used to reduce cholesterol) when the effectiveness of a statin taken alone is inadequate.
Maltese: Trevaclyn normalment jingħata flimkien ma' statin (il-mediċina standard użata għat-tnaqqis talkolesterol) meta l-effikaċja ta' statin meħud waħdu ma jkunx adegwat.
English: How has Trevaclyn been studied?
Maltese: Kif ġie studjat Trevaclyn?
English: They included a total of 2,349 patients who were taking either Trevaclyn or nicotinic acid.
Maltese: F'dawn b'kollox ħadu sehem 2,349 pazjent li kienu qegħdin jieħdu Trevaclyn jew aċidu nikotiniku.
English: Trevaclyn is a medicine containing two active substances: nicotinic acid (also known as niacin or vitamin B3) and laropiprant.
Maltese: Trevaclyn huwa mediċina li fiha żewġ sustanzi attivi: l-aċidu nikotiniku (magħruf ukoll bħala niacin jew vitamina
English: What is the risk associated with Trevaclyn?
Maltese: X'inhu r-riskju assoċjat ma' Trevaclyn?
English: Why has Trevaclyn been approved?
Maltese: Għaliex ġie approvat Trevaclyn?
English: Trevaclyn was effective in reducing the blood levels of LDL cholesterol.
Maltese: Trevaclyn kien effikaċi fit-tnaqqis tal-livelli ta' kolesterol LDL fid-demm.
English: Flushing due to nicotinic acid is thought to occur because of the release of a substance called ‘prostaglandin D2' (PGD2) from cells in the skin, which dilates (widens) the blood vessels in the skin.
Maltese: Huwa maħsub li l-ħmura fil-wiċċ minħabba l-aċidu nikotiniku sseħħ minħabba r-rilaxx ta' sustanza magħrufa bħala ‘prostaglandin D2' (PGD2) minn ċelloli fil-ġilda, li twessa' l-arterji u l-vini fil-ġilda.
English: The effects of Trevaclyn were first tested in experimental models before being studied in humans.
Maltese: L-effetti ta' Trevaclyn għall-ewwel ġew ittestjati f'mudelli sperimentali qabel ma ġew studjati fuq ilbniedem.
English: Trevaclyn is used in addition to diet and exercise in patients with dyslipidaemia (abnormally high levels of fat in the blood), particularly ‘combined mixed dyslipidaemia' and ‘primary hypercholesterolaemia'.
Maltese: Trevaclyn jintuża flimkien mad-dieta u l-eżerċizzju f'pazjenti b'dislipidemija (livelli għoljin b'mod anormali ta' xaħam fid-demm), b'mod partikolari ‘dislipidemija mħallta kombinata' u ‘livell għoli primarju ta' kolesterol'.
English: Primary means that the hypercholesterolaemia does not have any identifiable cause.
Maltese: Primajru jfisser li l-livell għoli ta' kolesterol ma jkollux kawża identifikabbli.