FrancophonIA/ELRC3.0 huggingface dataset:
English: Initial doses should be lower and subsequent dose titration should be more gradual because of greater chance of undesirable effects especially in very old and frail patients.
Bulgarian: Startdosis bør være lavere og efterfølgende dosistitrering bør se ske mere gradvist, grundet større risiko for bivirkninger, særligt hos meget gamle og skrøbelige patienter.
English: Reproduction toxicology studies in the rat, rabbit and monkey did not disclose any teratogenic properties.
Bulgarian: Reproduktionsstudier hos rotter, kaniner og aber afslørede ingen teratogene egenskaber.
English: Because of its potent, saturable binding to ACE and slow dissociation from the enzyme, ramiprilat shows a prolonged terminal elimination phase at very low plasma concentrations.
Bulgarian: Grundet den potente mættelige binding til ACE og langsomme adskillelse fra enzymet, viser ramiprilat en forlænget terminal eliminationsfase ved meget lave plasmakoncentrationer.
English: Pharmacokinetics and Metabolism Absorption
Bulgarian: Farmakokinetik og metabolisme Absorption
English: Raynaud's phenomenon
Bulgarian: Raynauds fænomen
English: Do not drive to the hospital, get somebody else to take you or call for an ambulance.
Bulgarian: til at køre dig, eller ring efter en ambulance.
English: 4.4 Special Warnings and Precautions for Use
Bulgarian: 4.4 Særlige advarsler og forsigtighedsregler vedrørende brugen
English: BATCH NUMBER
Bulgarian: BATCHNUMMER
English: TRITACE is not recommended for use in children and adolescents below 18 years of age due to insufficient data on safety and efficacy.
Bulgarian: TRITACE anbefales ikke til behandling af børn og unge under 18 år, da der er utilstrækkelige data om sikkerhed og effekt i denne population.
English: o Patients at particular risk of hypotension
Bulgarian: o Patienter med særlig risiko for hypertension
English: • Burning sensation
Bulgarian: Brændende fornemmelse
English: The indication for cardiovascular prevention is justified by the results of HOPE study.
Bulgarian: Indikationen for kardiovaskulær profylakse begrundes med resultaterne af HOPE-undersøgelsen.
English: The study showed that ramipril statistically significantly decreases the incidence of myocardial infarction, death from cardiovascular causes and stroke, alone and combined (primary combined events).
Bulgarian: Studiet viste, at ramipril statistisk signifikant nedsatte forekomsten af myokardie infarkt, død af kardiovaskulære årsager og slagtilfælde, isoleret eller kombineret (primære kombinerede events).
English: • If you have collagen vascular disease such as scleroderma or systemic lupus erythematosus
Bulgarian: Har kollagen vaskulær sygdom såsom skleroderma eller systemisk lupus erythematosus
English: If you are concerned about how much you can drink while you are taking TRITACE, discuss this with your doctor as medicines used to reduce blood pressure and alcohol can have additive effects.
Bulgarian: Hvis du er bekymret for hvor meget du må drikke samtidig med at du er i behandling med TRITACE, bør du tale med din læge, da blodtrykssænkende medicin kan forstærke virkningen af alkohol.
English: In addition to conventional therapy with diuretics and optional cardiac glycosides, ramipril has been shown to be effective in patients with functional classes II-IV of the New-York Heart Association.
Bulgarian: Ud over den konventionelle behandling med diuretika og hjerteglykosider, er ramipril vist effektiv hos patienter i New-York Heart Associations funktionelle klasser II-IV.
English: Two administrations per day are preferable.
Bulgarian: Administration 2 gange dagligt er at foretrække”.
English: Pregnancy: ACE inhibitors such as ramipril, or Angiotensin II Receptor Antagonists (AIIRAs) should not be initiated during pregnancy.
Bulgarian: Graviditet: ACE-hæmmere såsom ramipril eller Angiotension II Receptor Antagonister (AIIRA) bør ikke påbegyndes under graviditet.
English: TRITACE may lower your blood sugar amounts.
Bulgarian: TRITACE kan nedsætte blodsukkerniveauet.
English: Cardiovascular prevention/Nephroprotection;
Bulgarian: Kardiovaskulær forebyggelse/nyrebeskyttelse;
English: • If you have high amounts of potassium in your blood (shown in blood test results)
Bulgarian: Har højt indhold af kalium i dit blod (set i blodprøveresultater)
English: Other side effects reported:
Bulgarian: Andre rapporterede bivirkninger:
English: The bioavailability of the active metabolite ramiprilat after oral administration of 2.5 mg and 5 mg ramipril is 45 %.
Bulgarian: Biotilgængeligheden af den aktive metabolit ramiprilat efter oral administration af 2,5 mg og 5 mg ramipril er 45 %.
English: Characteristically, the cough is nonproductive, persistent and resolves after discontinuation of therapy.
Bulgarian: Det er karakteristisk for hosten, at den er nonproduktiv, vedvarende og ophører ved seponering af behandlingen.
English: Sweden sanofi-aventis AB Box 14142
Bulgarian: Sverige sanofi-aventis AB Box 14142
English: The maintenance dose is divided in 2 administrations per day where possible.
Bulgarian: Vedligeholdelsesdosis opdeles i to daglige doser, hvor det er muligt.
English: Adverse reactions frequency is defined using the following convention: Very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000), not known (cannot be estimated from the available data).
Bulgarian: ikke almindelig (≥ 1/1,000 til < 1/100); sjælden (≥ 1/10,000 til < 1/1,000); meget sjælden (< 1/10,000), Ikke kendt (kan ikke estimeres ud fra forhåndenværende data).
English: Metabolism
Bulgarian: Metabolisme
English: It is recommended that treatment with angiotensin converting enzyme inhibitors such as ramipril should be discontinued where possible one day before surgery.
Bulgarian: Det anbefales at behandling med angiotensin converting enzyme-hæmmere såsom ramipril seponeres, om muligt en dag før operationen.
English: There is a risk of impairment of renal function, particularly in patients with congestive heart failure or after a renal transplant.
Bulgarian: Der er risiko for nedsat nyrefunktion, særligt hos patienter med kongestiv hjerteinsufficiens eller efter nyretransplantation.
English: • TRITACE may be taken with or without food.
Bulgarian: Du kan anvende TRITACE sammen med, eller uden mad.
English: This can happen especially at the start of treatment, or when changing over from other preparations.
Bulgarian: Dette forekommer især ved starten af behandlingen, ved overgang fra andre lægemidler.
English: • Allopurinol (used to lower the uric acid in your blood)
Bulgarian: Allupurinol (anvendes til at mindske mængden af urinsyre i blodet)
English: B-1180 Brussels
Bulgarian: B-1180 Brussels Belgien
English: Polifarma S.p.A. Viale Dell' Arte, 69 I - 00144 Roma Italy
Bulgarian: Viale Dell' Arte, 69 I - 00144 Roma Italien
English: Népfürdo u.22 1138 Budapest Hungary
Bulgarian: Zentiva HU Kft Népfürdo u.22 1138 Budapest Ungarn
English: The AIRE study included more than 2,000 patients with transient/persistent clinical signs of heart failure after documented myocardial infarction.
Bulgarian: AIRE-studiet undersøgte mere end 2.000 patienter med forbigående/vedvarende kliniske tegn på hjerteinsufficiens efter dokumenteret myokardieinfarkt.
English: NV AstraZeneca SA Egide Van Ophemstraat 110 B-1180 Brussels Belgium
Bulgarian: NV AstraZeneca SA Egide Van Ophemstraat 110 B-1180 Brussels Belgien
English: 81105 Bratislava
Bulgarian: 81105 Bratislava Slovak Republic
English: The primary analysis showed that 117 (6.5 %) participants on ramipril and 149 (8.4 %) on placebo developed overt nephropathy, which corresponds to a RRR 24 %; 95 % CI [3-40], p = 0.027.
Bulgarian: Den primære analyse viste, at 117 (6,5 %) af deltagerne på ramipril og 149 (8,4 %) på placebo udviklede utilsløret nefropati, hvilket stemmer overens med RRR 24 %; 95 % KI [3-40], p=0,027.
English: If you have any further questions on the use of this product, ask your doctor or pharmacist.
Bulgarian: Hvis du har yderligere spørgsmål om anvendelsen af dette produkt kan du spørge på apoteket eller hos lægen.
English: Non-steroidal anti-inflammatory drugs and acetylsalicylic acid: Reduction of the antihypertensive effect of TRITACE is to be anticipated.
Bulgarian: Nonsteroide antiinflammatoriske stoffer og acetylsalicylsyre: Reduktionen af den antihypertensive effekt af TRITACE er forventelig.
English: Children
Bulgarian: Børn
English: As with other ACE inhibitors, ramipril may be less effective in lowering blood pressure in black people than in non black patients, possibly because of a higher prevalence of hypertension with low renin level in the black hypertensive population.
Bulgarian: Som med andre ACE-hæmmere kan ramipril være mindre effektiv til sænkning af blodtrykket hos sorte patienter end hos ikke-sorte patienter, sandsynligvis på grund af en højere prævalens af hypertension med lavt renin niveau hos den sorte, hypertensive population.
English: TRITACE may increase the amount of lithium in your blood.
Bulgarian: TRITACE kan øge indholdet af litium i blodet.
English: 4.1 Therapeutic Indication
Bulgarian: 4.1 Terapeutiske indikationer
English: -Hypotension and renal dysfunction after acute myocardial infarction occurred more frequently with ramipril than placebo in the target population in the AIRE study.
Bulgarian: - Hypotension og nyredysfunktion efter akut myokardieinfarkt forekom hyppigere med ramipril end placebo i målpopulationen i AIRE-undersøgelsen.
English: NAME OF THE MEDICINAL PRODUCT
Bulgarian: LÆGEMIDLETS NAVN
English: Titration and maintenance dose
Bulgarian: Titrering og vedligeholdelsesdosis
English: Peak concentrations of ramiprilat in these patients, however, are not different from those seen in subjects with normal hepatic function.
Bulgarian: Maksimal koncentrationerne af ramiprilat hos disse patienter er dog ikke forskellige fra dem set hos subjekter med normal leverfunktion.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER
Bulgarian: NAVN OG ADRESSE PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN
English: The dose titration steps and target dose are based on the result of the AIRE study.
Bulgarian: Dosistitreringstrin og den ønskede dosis er baseret på resultaterne fra AIRE-undersøgelsen.
English: AstraZeneca GmbH Tinsdaler Weg 183 22880 Wedel Germany
Bulgarian: AstraZeneca GmbH Tinsdaler Weg 183 22880 Wedel Tyskland
English: • Feeling shaky or confused
Bulgarian: Følelsen af at være oprevet eller forvirret
English: Furthermore, concomitant treatment of ACE inhibitors and NSAIDs may lead to an increased risk of worsening of renal function and to an increase in kalaemia.
Bulgarian: Desuden kan samtidig behandling med ACE-hæmmere og NSAID'er føre til øget risiko for forværret nyrefunktion og øget kaliæmi.
English: Check your blood sugar amounts closely while taking TRITACE
Bulgarian: Kontroller derfor dit blodsukker nøje når du anvender TRITACE.
English: • Red and swollen tongue
Bulgarian: Rød og hævet tunge
English: QUALITATIVE AND QUANTITATIVE COMPOSITION [To be completed nationally]
Bulgarian: KVALITATIV OG KVANTITATIV SAMMENSÆTNING [Udfyldes nationalt]
English: Studies involving chronic oral administration have been conducted in rats, dogs and monkeys.
Bulgarian: Der blevet foretaget studier kronisk oral administration hos rotter, hunde og aber. Der er fundet
English: A single oral dose of ramipril produced an undetectable level of ramipril and its metabolite in breast milk.
Bulgarian: En enkelt oral dosering af ramipril gav et ikke-detekterbart niveau af ramipril, og dets metabolit i modermælk.
English: Excretion of the metabolites is primarily renal.
Bulgarian: Udskillelse af metabolitterne foregår primært renalt.
English: The safety profile of ramipril includes persistent dry cough and reactions due to hypotension.
Bulgarian: Sikkerhedsprofilen for ramipril inkluderer vedvarende tør hoste og reaktioner på grunder a hypotension.
English: Oral administration of ramipril has been found to be devoid of acute toxicity in rodents and dogs.
Bulgarian: Oral administration af ramipril er blevet vist uden akut toksicitet hos gnavere og hunde.
English: TRITACE can be taken before, with or after meals, because food intake does not modify its bioavailability (see section 5.2).
Bulgarian: TRITACE kan tages før, under eller efter måltider, da fødeindtag ikke ændrer biotilgængeligheden.
English: PHARMACEUTICAL FORM Tablet
Bulgarian: LÆGEMIDDELFORM Tablet
English: The dose should be individualised according to the patient profile (see section 4.4) and blood pressure control.
Bulgarian: Dosis skal fastlægges efter individuel vurdering ud fra patientprofilen (se afsnit 4.4) og blodtrykskontrol.
English: This may be given for an operation or any dental work.
Bulgarian: Skal bedøves. Dette kan være i forbindelse med en operation eller tandlægebesøg.
English: This belongs to a group of medicines called ACE inhibitors (Angiotensin Converting Enzyme Inhibitors).
Bulgarian: Stoffet tilhører en gruppe medicin der kaldes ACE hæmmere (Angiotensin Converting Enzyme Inhibitors).
English: • Feeling depressed, anxious, more nervous than usual or restless
Bulgarian: Nedtrygt, angstfornemmelse, mere nervøs end sædvanlig eller rastløshed
English: If such treatment is required, consideration should be given to using a different type of dialysis membrane or a different class of antihypertensive agent.
Bulgarian: 4.3) Hvis sådanne behandlinger er påkrævet bør det det overvejes at anvende en anden type dialysemembran eller en anden type antihypertensivum.
English: Steady state plasma concentrations of ramiprilat after once daily dosing with the usual doses of ramipril are reached by about the fourth day of treatment.
Bulgarian: Steady-state plasmakoncentration af ramiprilat efter en daglig dosering med sædvanlig dosis ramipril opnås omtrent på behandlingens fjerdedag.
English: As an expression of the pharmacodynamic activity of ramipril, pronounced enlargement of the juxtaglomerular apparatus has been noted in the dog and monkey from daily doses of 250 mg/kg/d.
Bulgarian: Som udtryk for den farmakodynamiske aktivitet af ramipril er der noteret udtalt forstørrelse af det nærglomerulære apparat hos hunde og aber fra daglige doser på 250 mg/kg/dag.
English: Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation.
Bulgarian: Nedsat angiotensin II dannelse og hæmningen af bradykinin nedbrydning fører til vasodilatation.
English: ANNEX II SCIENTIFIC CONCLUSIONS AND GROUNDS FOR AMENDMENT OF THE SUMMARIES OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET PRESENTED BY THE EMEA
Bulgarian: BILAG II FAGLIGE KONKLUSIONER OG BEGRUNDELSER FOR ÆNDRING AF PRODUKTRESUMÉERNE, ETIKETTERINGEN OG INDLÆGSSEDLEN FREMLAGT AF EMEA
English: Pharmacodynamic effects
Bulgarian: Farmakodynamiske effekter
English: Particularly careful monitoring is required in patients with renal impairment (see section 4.2).
Bulgarian: Særligt grundig monitorering er påkrævet hos patienter med nedsat nyrefunktion (se pkt. 4.2).
English: Adults
Bulgarian: Voksne
English: The average response to ACE inhibitor monotherapy was lower in black (AfroCaribbean) hypertensive patients (usually a low-renin hypertensive population) than in non-black patients.
Bulgarian: Det gennemsnitlige respons på ACE hæmmer monoterapi var lavere hos sorte (Afro-Caribbean) hypertensive patienter (sædvanligvis en lav-renin hypertensiv befolkning) end hos ikke-sorte patienter.
English: • Steroid medicines for inflammation such as prednisolone
Bulgarian: Steroider mod betændelse såsom prednisolon
English: If you forget to take TRITACE
Bulgarian: Hvis du har glemt at tage TRITACE
English: These can be signs of liver problems such as hepatitis (inflammation of the liver) or liver damage.
Bulgarian: Dette kan være tegn på leverbetændelse såsom hepatitis eller lever skade.
English: If you become pregnant while on TRITACE, tell your doctor immediately.
Bulgarian: Hvis du bliver gravid mens du er i behandling med TRITACE, skal du fortælle det
English: (NSAIDs) such as ibuprofen or indometacin and aspirin)
Bulgarian: som f.eks. ibuprofen indometacin eller aspirin)
English: - Treatment of hypertension.
Bulgarian: − Behandling af hypertension
English: This is because TRITACE can affect the way some other medicines work.
Bulgarian: Dette er fordi TRITACE kan påvirke den måde anden medicin virker på ligesom anden medicin kan påvirke den måde TRITACE virker på.
English: Neutropenia/agranulocytosis, as well as thrombocytopenia and anaemia, have been rarely seen and bone marrow depression has also been reported.
Bulgarian: Neutropeni/agranulocytose, såvel som trombocytopeni og anæmi, er sjældent set og knoglemarvsdepression er også rapporteret.
English: NL-2800 BD Gouda The Netherlands
Bulgarian: NL-2800 BD Gouda The Holland
English: • Swelling of the face, lips or throat which make it difficult to swallow or breathe, as well as itching and rashes.
Bulgarian: Hævelse af ansigtet, læberne eller halsen, der gør det svært at trække vejret eller synke, ligesom kløe eller udslæt.
English: • Blocked nose, difficulty breathing or worsening of asthma
Bulgarian: Tilstoppet næse, vejrtrækningsbesvær eller forværring af astma
English: The CHMP adopted the harmonised indication: “Treatment of hypertension”.
Bulgarian: samme i alle EU-lande. CHMP har vedtaget den harmoniserede indikation: ”Behandling af hypertension”.
English: Visual disturbance including blurred vision
Bulgarian: Synsforstyrrelser, inklusive sløret syn.
English: Bronchospasm including asthma aggravated, nasal congestion
Bulgarian: Bronchospasme, inklusiv forværret asthma, nasal kongestion,
English: Mechanism of action
Bulgarian: Virkningsmekanisme
English: Cardiovascular prevention
Bulgarian: Kardiovaskulær forebyggelse
English: The likelihood and severity of anaphylactic and anaphylactoid reactions to insect venom and other allergens are increased under ACE inhibition.
Bulgarian: Sandsynligheden og sværhedsgraden af anafylaktisk og anafylaktoide reaktioner på insektgift og andre allergener er øget under ACE-hæmning.
English: • Fainting, hypotension (abnormally low blood pressure), especially when you stand or sit up quickly
Bulgarian: Besvimelse, for lavt blodsukker (hypotension), især hvis du rejser dig eller sætter dig op
English: Not known
Bulgarian: sjælden Ikke kendt
English: This leaflet was last approved in {MM/YYYY} [To be completed nationally]
Bulgarian: Denne indlægsseddel blev senest godkendt { MM/ÅÅÅÅ } [Udfyldes nationalt]
English: Should the decision be taken to treat these patients, it is recommended that therapy be started at 1.25 mg once daily and that particular caution be exercised in any dose increase.
Bulgarian: Hvis der tages en beslutning om at behandle disse patienter, anbefales det at behandlingen startes ved 1,25 mg en gang daglig, og at der vises særlige hensyn ved alle dosisforøgelser.
English: OTHER
Bulgarian: ANDET
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON
Bulgarian: MÆRKNING DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE YDERKARTON
English: Blood and lymphatic system disorders
Bulgarian: Blod og lymfesystem*
English: • Lithium (for mental health problems).
Bulgarian: Litium (mod mental forstyrrelser).
English: A. Juozapavičiaus g. 6/2 LT-09310 Vilnius Lithuania
Bulgarian: 6/2 LT-09310 Vilnius Lithauen
English: NL-2803 PE Gouda The Netherlands
Bulgarian: NL-2803 PE Gouda The Holland
English: Ramipril is almost completely metabolised to ramiprilat, and to the diketopiperazine ester, the diketopiperazine acid, and the glucuronides of ramipril and ramiprilat.
Bulgarian: Ramipril bliver næsten fuldstændigt metaboliseret til ramiprilat, og til de tilsvarende diketopiperazinestre, diketopiperazinsyrer og gluconoriderne af ramipril og ramiprilat.
English: Capsule
Bulgarian: Kapsel
English: The drug had beneficial effects on cardiac haemodynamics (decreased left and right ventricular filling pressures, reduced total peripheral vascular resistance, increased cardiac output and improved cardiac index).
Bulgarian: Stoffet havde gunstige virkninger på kardiel hæmodynamik (nedsat fyldningstryk i venstre og højre ventrikel, reduceret total perfifer vaskulær modstand, øget hjerteydelse og øget hjerteindeks).
English: TRITACE is not recommended during the first trimester of pregnancy (see section 4.4) and contraindicated during the second and third trimesters of pregnancy (see section 4.3).
Bulgarian: ikke anvendes under graviditetens første trimester (se punkt 4.4) og er kontraindiceret under graviditetens andet og tredje trimester.
English: In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin.
Bulgarian: synonym med angiotensin-converting enzym; kininase II). I plasma og væv katalyserer dette enzym ændringen af angiotensin I til den aktive vasokonstriktor substans angiotensin II og også nedbrydningen af det aktive vasodilatator bradykinin.
English: Taking TRITACE with food and alcohol
Bulgarian: Brug af TRITACE sammen med mad og drikke
English: SANOFI-AVENTIS SPA Viale Bodio, 37/b 20158 Milano
Bulgarian: SANOFI-AVENTIS SPA Viale Bodio, 37/b 20158 Milano Italien
English: - Transient or persistent heart failure post MI
Bulgarian: -Forbigående eller vedvarende hjerteinsufficiens post MI
English: • To treat high blood pressure (hypertension)
Bulgarian: Mod forhøjet blodtryk (hypertension)
English: 4.6 Pregnancy and Lactation
Bulgarian: 4.6 Graviditet og amning
English: This results in elevated plasma concentrations of ramiprilat, which decrease more slowly than in subjects with normal renal function.
Bulgarian: Det bevirker forhøjede plasmakoncentrationer af ramiprilat, som falder langsommere end hos patienter med normal nyrefunktion.
English: SCIENTIFIC CONCLUSIONS
Bulgarian: FAGLIGE KONKLUSIONER
English: Other side effects include: Please tell your doctor if any of the following gets serious or lasts longer than a few days.
Bulgarian: Andre bivirkninger: Kontakt straks lægen, hvis én af følgende bivirkninger bliver alvorlige eller varer længere end et par dage:
English: The CHMP recommended a contraindication only for the second and third trimester of pregnancy in line with PhVWP wording on use of AEC-I in pregnancy.
Bulgarian: CHMP anbefalede kun en kontraindikation for graviditetens andet og tredje trimester i overensstemmelse med formuleringen fra arbejdsgruppen vedrørende lægemiddelovervågning i forbindelse med brug af ACE-I under graviditet.
English: Any unused product or waste material should be disposed of in accordance with local requirements.
Bulgarian: samt affald heraf bør destrueres i henhold til lokale retningslinier
English: Disturbance in attention
Bulgarian: Opmærksomhedsforstyrrelser
English: The Rapporteurs are of the opinion that amended wording, the lower age limit of 55 years, is recommended.
Bulgarian: Rapportørerne er af den opfattelse, at der anbefales en ændret ordlyd for den nedre aldersgrænse på 55 år. Selektiv inklusion af et sekundært endepunkt - generel dødelighed - anbefales ikke.
English: Plasma concentrations of ramiprilat decline in a polyphasic manner.
Bulgarian: Plasmakoncentrationerne af ramiprilat falder polyfasisk.
English: Neutropenia/agranulocytosis
Bulgarian: Neutropeni/agranulocytose
English: Depressed mood, anxiety, nervousness, restlessness, sleep disorder including somnolence
Bulgarian: Nedtrykthed, angst, nervøsitet, rastløshed, søvnforstyrrelser inklusiv somnolens
English: Angioedema; very exceptionally, the airway obstruction resulting from angioedema may have a fatal outcome; pruritus, hyperhidrosis
Bulgarian: Angioødem; særlig sjældent kan luftvejsobstruktion på grund af angioødem have dødeligt udfald; pruritus, svedtendens
English: The administration of ramipril to female rats during the fetal period and lactation produced irreversible renal damage (dilatation of the renal pelvis) in the offspring at daily doses of 50 mg/kg body weight or higher.
Bulgarian: Ramipriladministration til hunrotter under føtalperioden og amning gav irreversible nyreskader (udvidelse af renalt pelvis) hos afkommet, ved daglige doser på 50 mg/kg eller højere.