FrancophonIA/ELRC3.0 huggingface dataset:
English: Before going to bed, wash your hands and the treatment area carefully with mild soap and water.
Danish: Før du går i seng, skal du vaske dine hænder og det område, som skal behandles, med mild sæbe og vand.
English: Squamous cell carcinoma (SCC) was reported in 1.3% (2/160) of patients treated with imiquimod 3.75%, in 0.6% (1/159) treated with vehicle.
Danish: Planocellulært karcinom (SCC) blev rapporteret hos 1,3% (2/160) af patienterne behandlet med imiquimod 3,75%, og i 0,6% (1/159) som blev behandlet med vehikelcremen.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS SACHET TEXT
Danish: MINDSTEKRAV TIL MÆRKNING PÅ SMÅ INDRE EMBALLAGER TEKST PÅ BREVE
English: Apply a thin layer of Zyclara to the affected area.
Danish: Smør et tyndt lag Zyclara på det angrebne område.
English: If you forget to use Zyclara
Danish: Hvis du har glemt at bruge Zyclara
English: Medicinal product subject to medicinal prescription.
Danish: Lægemidlet er receptpligtigt.
English: Zyclara (per application: up to 2 sachets, 250 mg imiquimod cream per sachet) should be applied once daily before bedtime to the skin of the affected treatment field (area) for two treatment cycles of 2 weeks each separated by a 2-week no-treatment cycle or as directed by the physician.
Danish: Zyclara (per applikation: op til 2 breve, 250 mg imiquimod creme per brev) skal appliceres én gang dagligt før sengetid på huden i det angrebne område, som skal behandles i 2 behandlingsperioder af 2 uger hver, adskilt af en 2-ugers ikke behandlingsperiode eller som foreskrevet af lægen.
English: Boxes of 14, 28, and 56 single-use polyester/ white low density polyethylene/ aluminium foil sachets, containing 250 mg of cream.
Danish: Æsker med 14, 28 og 56 engangsbreve af polyester/hvid lavdensitets polyethylen/aluminiumfolie, indeholdende 250 mg creme.
English: When any skin reaction has gone you may then continue with your treatment in the recommended regular schedule.
Danish: Når en eventuel hudreaktion er forsvundet, kan du fortsætte med den anbefalede behandling.
English: In a follow-up study where initially cleared patients with imiquimod 3.75% were followed for at least 14 months without any further AK-treatment, 40.5% of the patients showed sustained complete clearance of the whole treatment area (either full face or scalp) There are no data for imiquimod 3.75% on long-term clearance beyond that.
Danish: I en opfølgende undersøgelse hvor patienter, som var initialt clearet med imiquimod 3,75%, blev fulgt i mindst 14 måneder uden yderligere AK-behandling, viste 40,5% af patienterne vedvarende total clearance af hele behandlingsområdet (enten hele ansigtet eller hovedbunden).
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Zyclara therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Danish: Det skal besluttes, om amning eller behandling med Zyclara skal ophøre, idet der tages højde for fordelene ved amning for barnet i forhold til de terapeutiske fordele for moderen.
English: Actinic keratosis lesions that have cleared after two Zyclara treatment cycles of 2 weeks and subsequently recur can be re-treated with one or two further Zyclara treatment cycles of 2 weeks following an at least 12 weeks treatment pause.
Danish: Aktinisk keratose læsioner, som er forsvundet efter to behandlingsforløb af 2 uger med Zyclara og senere recidiverer, kan behandles med yderligere et eller to behandlingsforløb af 2 uger med Zyclara, efterfulgt af en behandlingspause i mindst 12 uger.
English: If flu-like symptoms or feeling discomfort or intense local skin reactions occur, a rest period of several days may be taken.
Danish: Hvis der optræder influenza-lignende symptomer eller stærke lokale hudreaktioner, kan en pause på flere dage tages.
English: Contact with eyes, lips, and nostrils should be avoided.
Danish: Kontakt med øjne, læber og næsebor bør undgås.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu.
Danish: Yderligere information om Zyclara findes på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu.
English: This medicine should only be used for actinic keratosis on the face and scalp.
Danish: Denne medicin skal kun bruges mod aktinisk keratose i ansigtet eller hovedbunden.
English: Application to broken skin could result in increased systemic absorption of imiquimod leading to a greater risk of adverse events (see section 4.8 and 4.9).
Danish: Påførsel på ødelagt hud kan resultere i øget systemisk absorption af imiquimod, hvilket fører til øget risiko for bivirkninger (se pkt.
English: - Each Zyclara 3.75% cream sachet contains 250 mg of a white to slightly yellow cream with a uniform appearance.
Danish: − Hvert brev Zyclara 3,75 % creme indeholder 250 mg hvid til let gullig creme med et ensartet udseende.
English: Remote site dermatologic reactions
Danish: Fjerntliggende dermatologiske reaktioner
English: Rare (≥ 1/10,000 to < 1/1,000);
Danish: Sjælden (≥ 1/10.000 til <1/1.000);
English: Your doctor will discuss if you should discontinue breastfeeding or discontinue Zyclara treatment.
Danish: Din læge vil fortælle, om du bør holde op med at amme eller stoppe behandlingen med Zyclara.
English: Do not cover the treated area with bandages or other dressings.
Danish: Dæk ikke det behandlede område med plaster eller anden forbinding.
English: You should continue application for the full treatment course even if all actinic keratosis appear to be gone.
Danish: Du bør fortsætte påføringen i hele behandlingsforløbet, selv om alle aktiniske keratoser ser ud til at være væk.
English: Patients with reduced haematologic reserve have not been studied in clinical trials.
Danish: Patienter med nedsatte hæmatologiske reserver er ikke blevet undersøgt i kliniske forsøg.
English: • Avoid contact with the eyes, lips and nostrils.
Danish: • Undgå kontakt med øjne, læber og næsebor.
English: Discard any cream remaining in a sachet after use.
Danish: Kassér eventuel resterende creme i et brev efter brug.
English: Treatment with imiquimod cream can be resumed after the skin reaction has moderated.
Danish: Behandling med imiquimod creme kan genoptages, når hudreaktionen er aftaget.
English: Each treatment cycle should not be extended beyond 2 weeks due to missed doses or rest periods.
Danish: Hver behandlingsperiode bør ikke forlænges ud over 2 uger på grund af manglende doser eller hvileperioder.
English: Cetyl alcohol and stearyl alcohol may cause local skin reactions (e.g. contact dermatitis).
Danish: Cetylalkohol og stearylalkohol kan medføre lokale hudreaktioner (f.eks. kontakt dermatitis).
English: However, neither 2-week treatment cycle should be extended due to missed doses or rest periods.
Danish: Imidlertid bør 2-ugers behandlingsperioden ikke blive forlænget på grund af manglende doser eller hvileperioder.
English: Blood system disorders
Danish: Forstyrrelser i blodsystemet
English: Sorbitan stearate
Danish: Sorbitanstearat
English: Remote site dermatologic reaction
Danish: Fjerntliggende dermatologisk reaktion
English: In the event of accidental contact, remove cream by rinsing with water.
Danish: Hvis dette sker, ved et uheld, skal cremen straks fjernes med vand.
English: If you have applied too much cream, wash the extra away with mild soap and water.
Danish: Hvis du har påført for meget creme, skal den overskydende creme vaskes væk med en mild sæbe og vand.
English: Depression Irritability
Danish: Ikke almindelig Depression Irritabilitet
English: Serious skin reactions (frequency not known) with skin lesions or spots on your skin that start out as small red areas and progress to look like mini targets, possibly with symptoms such as itching, fever, overall ill feeling, achy joints, vision problems, burning, painful or itchy eyes and mouth sores.
Danish: Kontakt straks din læge hvis nogle af disse alvorlige bivirkninger opstår, når du bruger denne medicin: Alvorlige hudreaktioner (hyppighed ikke kendt) med hudlæsioner eller pletter på din hud, som begynder som små røde områder og udvikles til små cirkler, sandsynligvis med symptomer som kløe, feber, følelse af ubehag, ømme led, synsproblemer, brændende, ømme eller kløende øjne og mundsår.
English: 319 subjects with AK were treated with up to 2 sachets once daily of imiquimod 3.75% cream, or a matching vehicle cream for two treatment cycles of 2 weeks separated by a 2-week no-treatment cycle.
Danish: 319 patienter med AK blev behandlet med op til 2 breve imiquimod 3,75% creme, én gang dagligt eller en tilsvarende vehikelcreme i to behandlingperioder af 2 uger-, adskilt af en 2-ugers ikke-behandlingsperiode.
English: METHOD OF ADMINISTRATION
Danish: Administrationsmetode
English: Talk to your doctor before you stop treatment with Zyclara.
Danish: Kontakt lægen, hvis du ønsker at stoppe behandlingen med Zyclara.
English: Other medicines and Zyclara
Danish: Brug af anden medicin sammen med Zyclara
English: Local skin reactions
Danish: Lokale hudreaktioner
English: Subjects applied up to two sachets of Zyclara 3.75% cream or vehicle daily to the skin of the affected area (either entire face or balding scalp, but not both) for two 2-week treatment cycles separated by a 2-week no-treatment cycle.
Danish: Forsøgspersonerne anvendte dagligt op til to breve Zyclara 3,75% creme eller vehiklet på huden i det berørte behandlingsområde (enten i hele ansigtet eller den skaldede hovedbund, men ikke begge dele) i en 2-ugers behandlingsperiode, adskilt af en 2ugers ikke-behandlingsperiode.
English: Avoid contact with the eyes, lips and nostrils.
Danish: Undgå kontakt med øjne, læber og næsebor.
English: Benzyl alcohol
Danish: Benzylalkohol
English: Influenza-like illness Pain
Danish: Influenza-lignende sygdom
English: Methyl parahydroxybenzoate (E 218) 2.0 mg/g cream Propyl parahydroxybenzoate (E 216) 0.2 mg/g cream Cetyl alcohol 22.0 mg/g cream Stearyl alcohol 31.0 mg/g cream Benzyl alcohol 20.0 mg/g cream
Danish: Hjælpestoffer, som behandleren skal være opmærksom på: Methylparahydroxybenzoat (E 218) 2,0 mg/g creme Propylparahydroxybenzoat (E 216) 0,2 mg/g creme Cetylalkohol 22,0 mg/g creme Stearylalkohol 31,0 mg/g creme Benzylalkohol 20,0 mg/g creme
English: Metabolism and nutrition disorders Common
Danish: Metabolisme og ernæring
English: If you miss a dose of Zyclara, wait until the next night to apply it and then continue with the regular schedule.
Danish: Hvis du har glemt at bruge Zyclara, skal du vente til næste aften med at påføre cremen og derefter fortsætte med din behandlingsplan.
English: Stearyl alcohol and cetyl alcohol may cause local skin reactions (e.g. contact dermatitis).
Danish: Stearylalkohol og cetylalkohol kan forårsage lokale hudreaktioner (f.eks. kontaktdermatitis).
English: Rare (may affect up to 1 in 1,000 people) - Flaring up of autoimmune conditions (a disease that results from an abnormal immune response is an autoimmune disease) - Skin reactions remote from the application site
Danish: − Opblussen af autoimmune tilstande (en autoimmun sygdom er en sygdom, som er resultatet af en unormal reaktion fra immunsystemet)
English: Due to its immunostimulating properties, imiquimod cream should be used with caution in patients who are receiving immunosuppressive medicinal products (see section 4.4).
Danish: Imiquimod creme virker immunstimulerende og bør derfor anvendes med forsigtighed til patienter, der er i behandling med immunosuppressive lægemidler (se pkt.
English: Methyl parahydroxybenzoate (E 218), and propyl parahydroxybenzoate (E 216), may cause allergic reactions (possibly delayed).
Danish: Methylparahydroxybenzoat (E 218), og propylparahydroxybenzoat (E 216) kan medføre allergiske reaktioner (muligvis forsinkede).
English: Patients with cardiac, hepatic or renal impairment were not included in clinical trials.
Danish: Patienter med nedsat hjerte-, lever- eller nyrefunktion var ikke inkluderet i de kliniske studier.
English: Once the discomfort stops you can resume your treatment schedule as recommended.
Danish: Så snart generne er ophørt, kan du begynde at bruge cremen igen, som anbefalet.
English: During a pharmacokinetic study with imiquimod 3.75% cream following application of 2 sachets once daily (18.75 mg imiquimod/day) for up to three weeks to the entire face and/or scalp (approximately 200 cm2), low systemic absorption of imiquimod was observed in patients with AK. Steady-state levels were achieved in 2 weeks and time to maximal concentrations (Tmax) ranged between 6 and 9 hours after last application.
Danish: I løbet af et farmakokinetisk studie med imiquimod creme 3,75% blev lav systemisk absorption af imiquimod observeret hos patienter med AK efter anvendelse af 2 breve én gang dagligt (18,75 mg imiquimod/dag) i op til tre uger i hele ansigtet og/eller hovedbunden (ca. 200 cm2).
English: Fertility No clinical data are available, potential risk for human is unknown.
Danish: Fertilitet Ingen kliniske data er tilgængelige.
English: Each sachet contains 9.375 mg of imiquimod in 250 mg cream (3.75%).
Danish: Hvert brev indeholder 9,375 mg imiquimod i 250 mg creme (3,75%).
English: Erythema
Danish: Erythem
English: Back pain Pain in extremity
Danish: Ikke almindelig Rygsmerter Smerter i ekstremiteter
English: Each treatment cycle should last no longer than two weeks, even if you have missed doses.
Danish: Hver behandlingsplan skal ikke vare mere end 2 uger, heller ikke hvis du har glemt at bruge den nogle gange.
English: If you accidentally swallow this medicine please contact your doctor immediately.
Danish: Hvis du ved et uheld kommer til at sluge Zyclara, skal du straks kontakte din læge.
English: For imiquimod no clinical data on exposed pregnancies are available.
Danish: Der er ingen kliniske data fra anvendelse af imiquimod til gravide kvinder.
English: Each sachet contains 9.375 mg of imiquimod in 250 mg cream (100 mg of cream contains 3.75 mg imiquimod).
Danish: Hvert brev indeholder 9,375 mg imiquimod i 250 mg creme (100 mg creme indeholder 3,75 mg imiquimod).
English: Zyclara 3.75% cream
Danish: Zyclara 3,75% creme
English: Uncommon (≥ 1/1,000 to < 1/100);
Danish: Ikke almindelig (≥ 1/1.000 til <1/100);
English: Cetyl alcohol
Danish: Cetylalkohol
English: • If the treated site becomes too uncomfortable, wash the cream off with mild soap and water.
Danish: • Hvis du oplever for kraftigt ubehag på det behandlede sted, vask cremen af med mild sæbe og vand.
English: - The other ingredients are isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), xanthan gum, purified water (see also section 2 “Zyclara contains methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol”).
Danish: - Øvrige indholdsstoffer: Isostearinsyre, benzylalkohol, cetylalkohol, stearylalkohol, hvid blød paraffin, polysorbat 60, sorbitanstearat, glycerol, methylparahydroxybenzoat (E218), propylparahydroxybenzoat (E216), xanthangummi, renset vand (se også afsnit 2 “Zyclara indeholder methylparahydroxybenzoat, propylparahydroxybenzoat, cetylalkohol stearylalkohol, og benzylalkohol”).
English: Skin hypopigmentation
Danish: Hud hypopigmentering
English: Application site reaction Application site pruritus Application site pain Application site swelling Application site burning Application site irritation Application site rash Fatigue
Danish: Reaktion på applikationsstedet Pruritus på applikationsstedet Smerte på applikationsstedet Hævelse på applikationsstedet Brænden på applikationsstedet Irritation på applikationsstedet Udslæt på applikationsstedet Træthed
English: Zyclara 3.75% cream imiquimod
Danish: Zyclara 3,75% creme Imiquimod
English: Zyclara contains methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol
Danish: Denne medicin indeholder methylparahydroxybenzoat, propylparahydroxybenzoat, cetylalkohol, stearylalkohol og benzylalkohol.
English: Haemoglobin decreased White blood cell count decreased Neutrophil count decreased Platelet count decreased
Danish: Nedsat hæmoglobin Nedsat antal hvide blodlegemer Nedsat neutrofiltal Nedsat blodpladetal
English: Patients with hepatic or renal impairment were not included in clinical trials.
Danish: Patienter med nedsat lever- eller nyrefunktion var ikke inkluderet i de kliniske studier.
English: Excipients: isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), xanthan gum, purified water.
Danish: Hjælpestoffer: Isostearinsyre, benzylalkohol, cetylalkohol, stearylalkohol, hvid blød paraffin, polysorbat 60, sorbitanstearat, glycerol, methylparahydroxybenzoat (E218), propylparahydroxybenzoat (E216), xanthangummi, renset vand.
English: Information on re-treating actinic keratosis lesions that have cleared after two Zyclara treatment cycles of 2 weeks and subsequently recur is given in section 4.2 and 5.1.
Danish: Information om gentagen behandling af aktinisk keratose læsioner, der har været væk efter to behandlingsforløb af 2 uger med Zyclara og senere recidiverer gives i pkt.
English: even if their sign of illness are the same as yours.
Danish: Det kan være skadeligt for andre, selvom de har de samme symptomer, som du har.
English: Mylan Healthcare B.V. Krijgsman 20
Danish: Mylan Healthcare B.V.
English: How to use Zyclara
Danish: Sådan skal du bruge Zyclara
English: Stearyl alcohol
Danish: Stearylalkohol
English: Skin exfoliation Skin oedema Skin ulcer
Danish: Skorpedannelse Hudeksfoliering Hud ødem
English: Methyl parahydroxybenzoate (E 218) Propyl parahydroxybenzoate (E 216) Xanthan gum
Danish: Methylparahydroxybenzoat (E218) Propylparahydroxybenzoat (E216) Xanthangummi
English: Very common (may affect more than 1 in 10 people) - Skin redness, scabbing, skin scaling, discharge, skin dryness, skin swelling, skin ulcer, and reduced skin pigmentation at the application site
Danish: − Rødme af huden, skorpedannelse, skæl, sekretion, tør hud, hævelser i huden, sår på huden, og nedsat hudpigmentering på påføringsstedet.
English: Application site erythema Application site scabbing Application site exfoliation Application site dryness Application site oedema Application site ulcer Application site discharge
Danish: Erythem på applikationsstedet Skorpedannelse på applikationsstedet Eksfoliering på applikationsstedet Tørhed på applikationsstedet Ødem på applikationsstedet Sår på applikationsstedet Sekretion på applikationsstedet
English: Application site dermatitis Application site bleeding Application site papules Application site paraesthesia Application site hyperaesthesia Application site inflammation Application site scar Application site skin breakdown Application site vesicles Application site warmth Asthenia
Danish: Ikke almindelig Dermatitis på applikationsstedet Blødning på applikationsstedet Papules på applikationsstedet Paræstesi på applikationsstedet Hyperæstesi på applikationsstedet Inflammation på applikationsstedet Ar på applikationsstedet
English: Frequency not known (frequency cannot be estimated from the available data) - Changes in skin colour Some patients have experienced changes in skin colour in the area where Zyclara was applied.
Danish: Nogle patienter har erfaret ændringer i hudfarve i området hvor Zyclara er påført.
English: Clinical efficacy and safety
Danish: Trafik- og arbejdssikkerhed
English: Common (≥ 1/100 to < 1/10);
Danish: Meget almindelig (≥ 1/10); Almindelig (≥ 1/100 til <1/10);
English: Zyclara should be left on the skin for approximately 8 hours; after this time it is essential that the cream is removed by washing the area and the hands with mild soap and water.
Danish: Efter denne tid er det vigtigt, at cremen fjernes ved vask af området samt hænderne med mild sæbe og vand.
English: Headache Dizziness
Danish: − Hårtab
English: Infections and infestations
Danish: Infektioner og parasitære sygdomme Almindelig
English: Common (may affect up to 1 in 10 people) - Further reactions at the application site e.g. skin inflammation, itching, pain, burning, irritation,
Danish: − Yderligere reaktioner på påføringsstedet f.eks. hudbetændelse, kløe, smerter, brænden, irritation og udslæt
English: Hepatic or renal impairment
Danish: Nedsat lever- eller nyrefunktion
English: Rarely, intense local inflammatory reactions including skin weeping or erosion can occur after only a few applications of imiquimod cream.
Danish: Selv efter få applikationer af imiquimod creme kan der, i sjældne tilfælde, ses intense lokale inflammatoriske reaktioner med væskende hud eller erosioner.
English: Respiratory, thoracic and mediastinal disorders
Danish: Knogler, led, muskler og bindevæv Almindelig
English: After application of the cream, throw away the opened sachet.
Danish: Smid det åbnede brev ud efter anvendelse af cremen.
English: Eye disorders
Danish: − Hævelse af øjenlåg
English: Check with your doctor or pharmacist if you are not sure.
Danish: - Spørg lægen, eller apotekspersonalet, hvis der er mere, du vil vide.
English: Musculoskeletal and connective tissue disorders
Danish: − Muskel- og ledsmerter
English: - Increase in liver enzymes There have been reports of increased liver enzymes.
Danish: Der har været rapporteret en øgning i leverenzymer
English: Discomfort
Danish: Amning
English: Excipients
Danish: Letargi
English: Infection Pustules
Danish: Hudinfektioner
English: Skin infection
Danish: Til anvendelse på huden
English: Nausea Diarrhoea Vomiting
Danish: Hovedpine Svimmelhed
English: If you use more Zyclara than you should
Danish: Hvis du har brugt for meget Zyclara
English: Seek medical attention right away if any of these severe side effects occur when using this medicine:
Danish: - Tal med lægen, eller apotekspersonalet, hvis en bivirkning bliver værre, eller du får bivirkninger, som ikke er nævnt her.
English: Chills
Danish: Frekvens
English: Myalgia Arthralgia
Danish: − Mundtørhed
English: The clinical significance of these results is not known.
Danish: Den kliniske betydning af disse resultater er ukendt.
English: The elimination half-life ranges from 9 to 15 hours.
Danish: Eliminationshalveringstiden går fra 9 til 15 timer.
English: These increases could be associated with jaundice.
Danish: Disse forøgelser kan være forbundet med gulsot.
English: The recommended dose is one tablet, twice a day.
Danish: Den anbefalede dosis er 1 tablet to gange om dagen.
English: Not known
Danish: Ikke kendte
English: In this study the majority of patients had a vital capacity less than 60%.
Danish: I denne undersøgelse havde flertallet af patienterne en vitalkapacitetsratio på mindre end 60 %.
English: No significant increased benefit can be expected from higher daily doses.
Danish: Der kan ikke forventes nogen signifikant bedre effekt af en højere daglig dosering.
English: In case of overdose, treatment is symptomatic and supportive.
Danish: I tilfælde af overdosering er behandling symptomatisk og understøttende.
English: However, the power of this study to detect differences between treatment groups was low.
Danish: Imidlertid var styrken af dette studie, til at bestemme forskelle mellem grupperne, lav.
English: This isolated finding was not noted in any other study or species.
Danish: Dette isolerede fund blev ikke observeret i andre studier eller arter.
English: About 90% of the dose is absorbed and the absolute bioavailability is 60 ± 18%.
Danish: Omkring 90 % absorberes og den absolutte biotilgængelighed er 60 ± 18 %.
English: The tablets should be taken by mouth, every 12 hours, at the same time of the day each day (e.g. in the morning and evening).
Danish: Du bør indtage tabletterne oralt hver 12. time, på samme tidspunkt af dagen hver dag (for eksempel om morgenen og om aftenen).
English: Readministration of riluzole to patients in this situation cannot be recommended.
Danish: Fornyet indgift af riluzol til patienter i denne situation kan ikke anbefales.
English: Glucuronides accounted for more than 85% of the metabolites in the urine.
Danish: Glucoroniderne udgør mere end 85 % af metabolitterne i urinen.