FrancophonIA/ELRC3.0 huggingface dataset:
English: Noxafil is used to treat adults (aged 18 years or over) with the following fungal diseases, when treatments with other antifungal medicines (amphotericin B, itraconazole or fluconazole) cannot be tolerated or have failed:
Slovenian: Zdravilo Noxafil se uporablja za zdravljenje naslednjih glivičnih obolenj pri odraslih (starejših od 18 let), kadar ti zdravljenja z drugimi protiglivičnimi zdravili (amfotericinom B, itrakonazolom ali flukonazolom) ne prenašajo ali pa zdravljenje ni bilo uspešno:
English: • chromoblastomycosis and mycetoma (long-term fungal infections of the skin or the tissue just below the skin, usually caused by fungal spores infecting wounds due to thorns or splinters),
Slovenian: • kromoblastomikoze in micetoma (dolgotrajnih glivičnih okužb kože in podkožnega tkiva, ki ju navadno povzročajo glivične spore, ki okužijo nastale rane zaradi trnov ali trsk),
English: The active substance in Noxafil, posaconazole, is an antifungal medicine that belongs to the triazole group.
Slovenian: Zdravilna učinkovina zdravila Noxafil, posakonazol, je protiglivično zdravilo, ki spada v skupino triazolov.
English: What is the risk associated with Noxafil?
Slovenian: Kakšna tveganja so povezana z zdravilom Noxafil?
English: Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Noxafil, including the appropriate precautions to be followed by healthcare professionals and patients.
Slovenian: V skladu z njim so bile v povzetek glavnih značilnosti tega zdravila in navodilo za njegovo uporabo vključene informacije o varnosti, vključno s previdnostnimi ukrepi, ki jih morajo upoštevati zdravstveni delavci in bolniki.
English: The study included 107 patients with aspergillosis, 18 patients with fusariosis, 11 with chromoblastomycosis or mycetoma, and 16 with coccidioidomycosis.
Slovenian: V študijo je bilo vključenih 107 bolnikov z aspergilozo, 18 bolnikov s fuzariozo, 11 bolnikov s kromoblastomikozo ali micetomom in 16 s kokcidioidomikozo.
English: In invasive aspergillosis, a successful response at the end of treatment was seen in 42% of the patients taking Noxafil oral suspension, compared with 26% of the patients in the comparator group.
Slovenian: Pri invazivni aspergilozi so uspešen odziv ob koncu zdravljenja ugotovili pri 42 % bolnikov, ki so prejemali peroralno suspenzijo zdravila Noxafil, v primerjavi s 26 % bolnikov v primerjalni skupini.
English: Other common side effects include vomiting, diarrhoea, pyrexia (fever) and increased bilirubin (a sign of liver problems) in the blood.
Slovenian: Drugi pogosti neželeni učinki so bruhanje, driska, pireksija (povišana telesna temperatura) in povišane ravni bilirubina v krvi (kar nakazuje na težave z jetri).
English: Noxafil also successfully treated 11 of the 18 patients who had proven or probable fusariosis, 9 of the 11 patients with chromoblastomycosis or mycetoma, and 11 of the 16 patients with coccidioidomycosis.
Slovenian: Zdravilo Noxafil je prav tako uspešno ozdravilo 11 od 18 bolnikov, ki so imeli dokazano ali verjetno fuzariozo, 9 od 11 bolnikov s kromoblastomikozo ali micetomom in 11 od 16 bolnikov s kokcidioidomikozo.
English: The list of fungi against which Noxafil is active can be found in the summary of product characteristics (also part of the EPAR).
Slovenian: Za seznam glivic, proti katerim deluje zdravilo Noxafil, glejte povzetek glavnih značilnosti zdravila (ki je prav tako del EPAR).
English: • pimozide (used for treating mental illness),
Slovenian: • pimozid (ki se uporablja za zdravljenje duševnih bolezni),
English: Noxafil oral suspension, solution for infusion and gastro-resistant tablets are also used to prevent invasive fungal infections in patients whose immune system is weakened because of treatments they are receiving for blood or bone marrow cancers or medicines used in haematopoietic stem cell transplantation (a transplant of cells that make blood cells).
Slovenian: Peroralna suspenzija, raztopina za infundiranje in gastrorezistentne tablete zdravila Noxafil se lahko uporabljajo tudi za preprečevanje invazivne glivične okužbe pri bolnikih, ki imajo oslabljen imunski sistem zaradi zdravil za zdravljenje krvnega raka ali raka kostnega mozga ali zdravil, uporabljenih pri presaditvi krvotvornih matičnih celic (presaditvi celic, ki proizvajajo krvne celice).
English: The most common side effect with Noxafil, seen in more than one patient in 10, is nausea (feeling sick).
Slovenian: Najpogostejši neželeni učinek zdravila Noxafil, opažen pri 1 bolniku od 10, je navzeja (slabost).
English: • cisapride (used for stomach problems),
Slovenian: • cisaprid (ki se uporablja za zdravljenje želodčnih težav),
English: In one main study, Noxafil oral suspension was studied in 238 patients with invasive fungal infections that did not respond to standard antifungal treatment.
Slovenian: V eni glavni študiji so peroralno suspenzijo zdravila Noxafil proučevali pri 238 bolnikih z invazivnimi glivičnimi okužbami, ki se niso odzivali na standardno protiglivično zdravljenje.
English: • Noxafil tablets can be taken with or without food and should be swallowed whole with water; the tablets should not be crushed, chewed, broken or dissolved.
Slovenian: • Tablete zdravila Noxafil se lahko jemljejo s hrano ali brez nje, pri čemer jih je treba pogoltniti cele sočasno z vodo.
English: For the treatment and prevention of fungal infections, the recommended dose of Noxafil tablets or Noxafil solution for infusion is 300 mg twice a day on the first day followed by 300 mg once a day thereafter; the duration of treatment depends on the severity of the disease and the patient's response.
Slovenian: Pri zdravljenju in preprečevanju glivičnih okužb znaša priporočeni odmerek tablet ali raztopine za infundiranje zdravila Noxafil prvi dan 300 mg dvakrat na dan, zatem pa se nadaljuje z odmerkom 300 mg enkrat na dan, pri čemer je trajanje zdravljenja odvisno od resnosti bolezni in bolnikovega odziva.
English: In oropharyngeal candidiasis, Noxafil oral suspension was as effective as fluconazole.
Slovenian: Pri orofaringealni kandidozi je bila peroralna suspenzija zdravila Noxafil enako učinkovita kot flukonazol.
English: • terfenadine, astemizole (used for allergy),
Slovenian: • terfenadin, astemizol (ki se uporablja za zdravljenje alergij),
English: Noxafil oral suspension and tablets have different dosages and should not be used interchangeably.
Slovenian: Peroralna suspenzija in tablete zdravila Noxafil so na voljo v različnih odmerjanjih in niso medsebojno zamenljive.
English: For additional information, see the package leaflet.
Slovenian: Za več informacij glejte navodilo za uporabo.
English: Why has Noxafil been approved?
Slovenian: Zakaj je bilo zdravilo Noxafil odobreno?
English: • halofantrine (used to treat malaria),
Slovenian: • halofantrin (ki se uporablja za zdravljenje malarije),
English: In another main study involving 350 HIV-infected patients with oropharyngeal candidiasis, Noxafil oral suspension was compared with fluconazole.
Slovenian: V drugi glavni študiji, ki je vključevala 350 bolnikov, okuženih z virusom HIV in orofaringealno kandidozo, so peroralno suspenzijo zdravila Noxafil primerjali s flukonazolom.
English: • invasive aspergillosis (fungal infection caused by Aspergillus),
Slovenian: • invazivne aspergiloze (vrste glivične okužbe, ki jo povzroča Aspergillus),
English: Noxafil tablets and solution for infusion must not be used for the treatment of thrush.
Slovenian: Tablete in raztopina za infundiranje zdravila Noxafil se ne smejo uporabljati za zdravljenje ustnega oprha.
English: The ability to prevent infections was investigated in two additional main studies, where Noxafil oral suspension was compared with fluconazole in 600 stem cell transplant patients and with fluconazole or itraconazole in 602 patients with blood or bone marrow cancer.
Slovenian: Učinkovitost peroralne suspenzije zdravila Noxafil pri preprečevanju okužb so proučevali v dveh dodatnih študijah, in sicer so ga pri 600 bolnikih, ki so imeli presaditev matičnih celic, primerjali s flukonazolom, pri 602 bolnikih s krvnim rakom ali rakom kostnega mozga pa s flukonazolom ali itrakonazolom.
English: • ergotamine or dihydroergotamine (used to treat migraine),
Slovenian: • ergotamin ali dihidroergotamin (ki se uporablja za zdravljenje migrene),
English: Noxafil oral suspension is also used as a first-line treatment for ‘thrush', a fungal infection of the mouth and throat due to Candida.
Slovenian: Peroralna suspenzija zdravila Noxafil se uporablja tudi kot zdravilo prve izbire za zdravljenje bolnikov z ustnim oprhom, tj. glivično okužbo ust in žrela, ki jo povzroča Candida.
English: Patients given the solution for infusion should be switched to Noxafil tablets or oral suspension as soon as the patient's condition allows it.
Slovenian: Bolniki, ki prejemajo raztopino za infundiranje, morajo čim prej, ko njihovo stanje to omogoča, preiti na uživanje tablet ali peroralne suspenzije zdravila Noxafil.
English: • fusariosis (fungal infection caused by Fusarium),
Slovenian: • fuzarioze (vrste glivične okužbe, ki jo povzroča Fusarium),
English: For the treatment of fungal infections, with the exception of oral candidiasis, Noxafil oral suspension is taken at a dose of 400 mg (10 ml) twice a day, or 200 mg (5 ml) four times a day in patients who cannot tolerate a meal.
Slovenian: Za zdravljenje glivičnih okužb, razen ustne kandidoze, se peroralna suspenzija zdravila Noxafil jemlje v odmerku 400 mg (10 ml) dvakrat na dan ali 200 mg (5 ml) štirikrat na dan pri bolnikih, ki ne prenesejo zaužitja hrane.
English: The CHMP concluded that, although the first study compared Noxafil with records of patients who were actually enrolled in that study, the effectiveness of Noxafil was shown.
Slovenian: CHMP je sklenil, da je bila učinkovitost zdravila Noxafil dokazana, četudi so zdravilo v prvi študiji primerjali s poročili bolnikov, ki so dejansko sodelovali v študiji.
English: In the prevention studies, Noxafil oral suspension was as effective as fluconazole in stem cell transplant patients, with 5% of patients developing an infection in the Noxafil group, and 9% in the comparator group.
Slovenian: V študijah preprečevanja bolezni je bila peroralna suspenzija zdravila Noxafil pri bolnikih s presaditvijo matičnih celic enako uspešna kot flukonazol, in sicer se je v skupini, ki je prejemala zdravilo Noxafil, okužba razvila pri 5 % bolnikov, v primerjalni skupini pa pri 9 %.
English: For the full list of all side effects reported with Noxafil, see the package leaflet.
Slovenian: Za celoten opis neželenih učinkov, o katerih so poročali pri uporabi zdravila Noxafil, glejte navodilo za uporabo.
English: For oral candidiasis, Noxafil oral suspension is taken as 200 mg (5 ml) on the first day followed by 100 mg (2.5 ml) once a day for the following 13 days.
Slovenian: Pri ustni kandidozi se prvi dan uporabi peroralna suspenzija zdravila Noxafil v odmerku 200 mg (5 ml), potem pa v odmerku 100 mg (2,5 ml) na dan naslednjih 13 dni.
English: • coccidioidomycosis (fungal infection of the lungs caused by breathing in spores).
Slovenian: • kokcidioidomikoze (glivične okužbe pljuč, ki jo povzroča vdihavanje spor).
English: Noxafil is an antifungal medicine that contains the active substance posaconazole; it is available as an oral suspension (40 mg/ml), a concentrate (300 mg) for solution for infusion (drip) into a vein and as gastroresistant tablets (100 mg).
Slovenian: Na voljo je v obliki peroralne suspenzije (40 mg/ml), koncentrata (300 mg) za pripravo raztopine za infundiranje (kapalno infuzijo) v veno in gastrorezistentnih tablet (100 mg).
English: The medicine was more effective than fluconazole or itraconazole in cancer patients, with 2% of patients developing an infection in the Noxafil group, and 8% in the comparator groups.
Slovenian: Pri bolnikih z rakom je bilo zdravilo Noxafil učinkovitejše od flukonazola ali itrakonazola - v skupini, ki je prejemala zdravilo Noxafil, se je okužba razvila pri 2 % bolnikov, v primerjalni skupini pa pri 8 %.
English: What is Noxafil?
Slovenian: Kaj je zdravilo Noxafil?
English: What is Noxafil used for?
Slovenian: Za kaj se zdravilo Noxafil uporablja?
English: How does Noxafil work?
Slovenian: Kako zdravilo Noxafil deluje?
English: How has Noxafil been studied?
Slovenian: Kako je bilo zdravilo Noxafil raziskano?
English: • quinidine (used for irregular heart beat),
Slovenian: • kinidin (ki se uporablja za zdravljenje motenj srčnega ritma),
English: How is Noxafil used?
Slovenian: Kako se zdravilo Noxafil uporablja?
English: For the prevention of invasive fungal infections, Noxafil oral suspension is given at a dose of 200 mg (5 ml) three times a day.
Slovenian: Pri preprečevanju invazivnih glivičnih okužb se uporablja peroralna suspenzija zdravila Noxafil v odmerku 200 mg (5 ml) trikrat na dan. Trajanje zdravljenja je odvisno od bolnikovega stanja.
English: This summary was last updated in November 2011.
Slovenian: Povzetek je bil nazadnje posodobljen novembra 2011.
English: In very rare cases, they may be serious or fatal.
Slovenian: V zelo redkih primerih so lahko resni ali povzročijo celo smrt.
English: If you want more information on the basis of the CVMP recommendations, read the scientific discussion (also part
Slovenian: Če želite več informacij, ki temeljijo na priporočilih CVMP, preberite znanstveno razpravo (ki je prav tako del EPAR).
English: Its purpose is to explain how the assessment done by the Committee for Medicinal Products for Veterinary Use (CVMP) on the basis of the documentation provided, led to the recommendations on the conditions of use.
Slovenian: Njegov namen je pojasniti, kako je Odbor za zdravila za uporabo v veterinarski medicini (CVMP) ocenil predloženo dokumentacijo, na podlagi katere je oblikoval priporočila glede pogojev uporabe zdravila.
English: What are the precautions for the person who gives the medicine or comes
Slovenian: Kakšne previdnostne ukrepe mora upoštevati oseba, ki daje zdravilo ali
English: They disappear once treatment has stopped.
Slovenian: Po končanem zdravljenju izzvenijo.
English: The European Commission granted a marketing authorisation valid throughout the European Union, for Flexicam on 10 April 2006 and an extension to Flexicam 5mg/ml solution for injection on 9 December 2008.
Slovenian: Evropska komisija je dovoljenje za promet z zdravilom Flexicam, veljavno po vsej Evropski uniji, odobrila dne 10. aprila 2006, podaljšanje dovoljenja za promet z zdravilom Flexicam 5mg/ml raztopina za injiciranje pa 9. decembra 2008.
English: What benefit has Flexicam shown during the studies?
Slovenian: Kakšne koristi je zdravilo Flexicam izkazalo med študijami?
English: If the product is swallowed by a person, the advice of a doctor should be sought immediately.
Slovenian: Če oseba zaužije zdravilo nenamerno, se je treba nemudoma posvetovati z zdravnikom.
English: A study looked at how Flexicam was absorbed and its effects in the body, in comparison with Metacam
Slovenian: V študiji so proučevali absorbiranje zdravila Flexicam ter njegove učinke na telo v primerjavi z zdravilom Metacam
English: Presentations of Flexicam oral suspension were subsequently not renewed.
Slovenian: Dovoljenja za promet s farmacevtskimi oblikami zdravila Flexicam peroralna suspenzija posledično niso bila podaljšana.
English: What is the risk associated with Flexicam?
Slovenian: Kakšna tveganja so povezana z zdravilom Flexicam?
English: The Committee for Medicinal Products for Veterinary Use (CVMP) considered that, in accordance with European Union requirements, Flexicam has been shown to be bioequivalent to Metacam 1.5 mg/ml oral suspension.
Slovenian: Odbor za zdravila za uporabo v veterinarski medicini (CVMP) je menil, da se je zdravilo Flexicam v skladu z zahtevami Evropske unije izkazalo kot biološko enakovredno zdravilu Metacam 1,5 mg/ml peroralna suspenzija.
English: Flexicam was presented as a pale green oral suspension (1.5mg/ml) for dogs (to be given mixed with food) and a yellow solution for injection (5mg/ml) for dogs and cats.
Slovenian: Zdravilo Flexicam je na voljo kot svetlo zelena peroralna suspenzija (1,5 mg/ml) za pse (ki se zmeša s hrano) in rumena raztopina za injiciranje (5 mg/ml) za pse in mačke.
English: Flexicam has been investigated in comparison with Metacam which is already authorised in the EU.
Slovenian: Zdravilo Flexicam so primerjali z zdravilom Metacam, ki že ima dovoljenje za promet v EU.
English: Flexicam contains meloxicam, which belongs to a class of medicines called non-steroidal antiinflammatory drugs (NSAIDs).
Slovenian: Zdravilo Flexicam vsebuje meloksikam, ki spada v skupino zdravil, imenovanih nesteroidna protivnetna zdravila (NSAID).
English: Meloxicam acts by inhibition of prostaglandin synthesis.
Slovenian: Meloksikam deluje tako, da zavira sintezo prostaglandinov.
English: Flexicam should not be administered to pregnant or lactating animals as the safety of the product has not been established in these cases.
Slovenian: Zdravilo Flexicam se ne sme uporabljati pri brejih živalih ali živalih v obdobju laktacije, ker varnost zdravila v teh primerih ni bila ugotovljena.
English: Why has Flexicam been approved?
Slovenian: Zakaj je bilo zdravilo Flexicam odobreno?
English: Flexicam should also not be used in animals suffering from gastrointestinal or hemorrhagic disorders and impaired renal or hepatic function, animals with known hypersensitivity to NSAIDs, and animals less than 6 weeks of age or in cats of less than 2 kg.
Slovenian: Zdravilo Flexicam se ne sme uporabljati pri živalih z obolenji prebavil ali hemoragičnimi obolenji ter pri motnjah jetrne ali ledvične funkcije, živalih z ugotovljeno preobčutljivostjo na nesteroidna protivnetna zdravila ter živalih, mlajših od 6 tednov, ali mačkah, lažjih
English: Studies have been carried out to prove that Flexicam is ‘bioequivalent' to the reference veterinary medicine: this means that Flexicam is equivalent to Metacam 1.5 mg/ml suspension in the way it is absorbed and used by the body.
Slovenian: Študije so pokazale, da je zdravilo Flexicam „biološko enakovredno“ referenčnemu veterinarskemu zdravilu - to pomeni, da se zdravilo Flexicam v telesu absorbira in uporablja enako kot zdravilo Metacam 1,5 mg/ml suspenzija.
English: What is Flexicam used for?
Slovenian: Za kaj se zdravilo Flexicam uporablja?
English: An oral follow-up therapy using meloxicam or other NSAIDs should not be used in cats, as no safe dosage for repeated oral administration has been established.
Slovenian: Pri mačkah zdravljenja ne smete nadaljevati s peroralno obliko meloksikama ali drugega nesteroidnega protivnetnega zdravila, ker pri njih še ni določen varen odmerek za nadaljevalno peroralno zdravljenje.
English: Flexicam contains meloxicam which belongs to a class of medicines having anti-inflammatory action.
Slovenian: Zdravilo Flexicam vsebuje meloksikam, ki spada v skupino zdravil s protivnetnim delovanjem.
English: Occasional side effects of Flexicam are those seen with NSAIDs, such as loss of appetite, vomiting, diarrhoea, blood appearing in the stools and apathy (lack of vitality).
Slovenian: Občasni neželeni učinki zdravila Flexicam so enaki kot pri drugih nesteroidnih protivnetnih zdravilih in obsegajo izgubo teka, bruhanje, drisko, kri v blatu in apatijo (pomanjkanje vitalnosti).
English: As the prostaglandins are substances that trigger inflammation, pain, exudation and fever, meloxicam
Slovenian: Prostaglandini so snovi, ki sprožajo vnetje, bolečino, izločanje tekočine in zvišano telesno temperaturo, meloksikam pa zmanjša
English: The CVMP concluded that the benefits of Flexicam exceed the risks for the alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders, reduction of postoperative pain and inflammation following orthopaedic and soft tissue surgery in dogs and reduction of post-operative pain after ovariohysterectomy and minor soft tissue surgery in cats and recommended that Flexicam be given a marketing authorisation.
Slovenian: Odbor za zdravila za uporabo v veterinarski medicini (CVMP) je zaključil, da so koristi zdravila Flexicam pri umirjanju vnetja in lajšanju bolečine pri akutnih in kroničnih mišičnoskeletnih obolenjih, lajšanju pooperativne bolečine in vnetja po ortopedskih operacijah in operacijah mehkega tkiva pri psih ter lajšanju pooperativne bolečine po ovariohisterektomiji in manjših operacijah mehkega tkiva pri mačkah večje od z njim povezanih tveganj, in priporočil, da se za zdravilo Flexicam odobri dovoljenje za promet.
English: Flexicam is efficacious in alleviating the inflammation and pain in both acute and chronic musculoskeletal disorders and reducing the post operative pain following orthopaedic and soft tissue surgery in dogs and in reducing the post-operative pain after ovariohysterectomy and minor soft tissue surgery in
Slovenian: Zdravilo Flexicam je učinkovito pri umirjanju vnetja in lajšanju bolečine pri akutnih in kroničnih mišično-skeletnih obolenjih ter lajšanju pooperativne bolečine po ortopedskih operacijah in operacijah mehkega tkiva pri psih ter lajšanju pooperativne bolečine po ovariohisterektomiji in manjših operacijah
English: Flexicam is a ‘generic': this means that Flexicam is similar to a ‘reference veterinary medicine' already authorised in the EU (Metacam 1.5 mg/ml oral suspension).
Slovenian: To pomeni, da je podobno „referenčnemu veterinarskemu zdravilu“, ki je že bilo odobreno v EU (zdravilu Metacam 1,5 mg/ml peroralna suspenzija).
English: How does Flexicam work?
Slovenian: Kako je bilo zdravilo Flexicam raziskano?
English: This can reduce the symptoms of gout.
Slovenian: To lahko zmanjša simptome protina.
English: The full EPAR for Febuxostat Mylan can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Febuksostat Mylan je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: Febuxostat Mylan should be started 2 days before chemotherapy and continued for at least 7 days.
Slovenian: Zdravljenje z zdravilom Febuksostat Mylan je treba začeti dva dni pred kemoterapijo in nadaljevati najmanj sedem dni.
English: The Committee recommended that Febuxostat Mylan be approved for use in the EU.
Slovenian: Priporočil je, da se zdravilo Febuksostat Mylan odobri za uporabo v EU.
English: Studies on the benefits and risks of the active substance in the approved uses have already been carried out with the reference medicine, Adenuric, and do not need to be repeated for Febuxostat Mylan.
Slovenian: Študije o koristih in tveganjih zdravilne učinkovine pri odobrenih načinih uporabe so že bile izvedene z referenčnim zdravilom Adenuric, zato jih ni treba ponoviti za zdravilo Febuksostat Mylan.
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) concluded that, in accordance with EU requirements, Febuxostat Mylan has been shown to have comparable quality and to be bioequivalent to Adenuric.
Slovenian: Odbor za zdravila za uporabo v humani medicini (CHMP) pri agenciji je zaključil, da je bilo v skladu z zahtevami EU dokazano, da ima zdravilo Febuksostat Mylan primerljivo raven kakovosti kot zdravilo Adenuric ter da mu je biološko enakovredno.
English: This is a summary of the European public assessment report (EPAR) for Febuxostat Mylan.
Slovenian: To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Febuksostat Mylan.
English: This usually reduces blood uric acid levels within two weeks, but the dose can be increased to 120 mg once a day if blood uric acid levels remain high (above 6 mg per decilitre) after two to four weeks.
Slovenian: To običajno zniža koncentracijo sečne kisline v krvi v dveh tednih, vendar pa je mogoče v primeru, če ostane koncentracija sečne kisline v krvi po dveh do štirih tednih visoka (nad 6 mg na deciliter), odmerek povečati na 120 mg enkrat na dan.