FrancophonIA/ELRC3.0 huggingface dataset:
English: If you cannot swallow the tablet(s), you may crush and combine them with a small amount of food or drink and take all the dose immediately.
Slovenian: Če tablete (tablet) ne morete pogoltniti, lahko tableto (tablete) zdrobite in dodate v manjšo količino redkega živila ali hrane ter nato takoj v celoti zaužijte.
English: • sensation of weakness in the limbs
Slovenian: • občutek šibkosti v udih,
English: No specific symptoms or signs have been identified following acute overdose with zidovudine or lamivudine apart from those listed as undesirable effects.
Slovenian: Po akutnem zaužitju prevelikega odmerka zidovudina ali lamivudina niso poročali o specifičnih simptomih ali znakih, razen tistih, ki so navedeni kot neželeni učinki.
English: For these patients and for patients, who are unable to swallow tablets, oral solutions of lamivudine and zidovudine are available.
Slovenian: Za te bolnike in bolnike, ki ne morejo pogoltniti tablet, sta lamivudin in zidovudin na voljo tudi v obliki peroralne raztopine.
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
Slovenian: Pri bolnikih z obstoječimi motnjami v delovanju jeter, vključno s kroničnim aktivnim hepatitisom, se med kombiniranim protiretrovirusnim zdravljenjem pogosteje pojavljajo nepravilnosti v delovanju jeter, zato je potrebno take bolnike nadzorovati v skladu s standardno prakso.
English: In vitro data tend to suggest that the continuation of lamivudine in anti-retroviral regimen despite the development of M184V might provide residual anti-retroviral activity (likely through impaired viral fitness).
Slovenian: In vitro pridobljeni podatki nakazujejo, da se pri nadaljevanju uporabe lamivudina v protiretrovirusnem režimu zdravljenja kljub razvoju M184V lahko ohrani rezidualno protiretrovirusno delovanje (verjetno zaradi okvare virusa).
English: No dosage adjustment necessary.
Slovenian: Prilagoditev odmerka ni potrebna.
English: The median (range) lamivudine and zidovudine tmax values were 0.75 (0.50-2.00) hours and 0.50 (0.25-2.00) hours respectively.
Slovenian: Srednja vrednost (razpon) tmax lamivudina je bila 0,75 ure (0,50 - 2,00), zidovudina pa 0,50
English: Limited data from clinical trials do not indicate a significantly increased risk of adverse reactions to zidovudine with cotrimoxazole (see interaction information above relating to lamivudine and cotrimoxazole), aerosolised pentamidine, pyrimethamine and acyclovir at doses used in prophylaxis.
Slovenian: Maloštevilni podatki kliničnih preskušanj ne kažejo bistveno večjega tveganja neželenih učinkov zidovudina s kotrimoksazolom (glejte informacije o medsebojnem delovanju zgoraj glede lamivudina in kotrimoksazola), aerosoliziranim pentamidinom, pirimetaminom in aciklovirjem pri odmerkih, ki se uporabljajo za profilakso.
English: Lamivudine/Zidovudine Teva is indicated in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infection (see section 4.2).
Slovenian: Zdravilo Lamivudin/zidovudin Teva je indicirano za kombinirano protiretrovirusno zdravljenje okužb z virusom humane imunske pomanjkljivosti (HIV) (glejte poglavje 4.2).
English: Liver disease: If lamivudine is being used concomitantly for the treatment of HIV and HBV, additional information relating to the use of lamivudine in the treatment of hepatitis B infection is available in the lamivudine 100 mg SmPC.
Slovenian: Bolezni jeter: V primeru sočasnega zdravljenja bolezni HIV in hepatitisa B z lamivudinom, so dodatne informacije, ki se nanašajo na uporabo lamivudina pri zdravljenju okužbe z virusom hepatitisa B, na voljo v Povzetku glavnih značilnosti za lamivudin 100 mg.
English: Neither lamivudine nor zidovudine are mutagenic in bacterial tests, but consistent with other nucleoside analogues, inhibit cellular DNA replication in in vitro mammalian tests such as the mouse lymphoma assay.
Slovenian: Niti lamivudin niti zidovudin v poskusih z bakterijami nista pokazala mutagenosti, vendar pa skladno z drugimi nukleozidnimi analogi inhibirata replikacijo celične DNK in vitro testih na celicah sesalcev, kot so celice mišjega limfoma.
English: The clinically relevant effects of lamivudine and zidovudine in combination are anaemia, neutropenia and leucopenia.
Slovenian: Učinki lamivudina in zidovudina v kombinaciji, ki imajo klinični pomen so anemija, nevtropenija in levkopenija.
English: Metabolism and nutrition disorders Rare: Lactic acidosis in the absence of hypoxaemia, anorexia
Slovenian: Presnovne in prehranske motnje Redki: laktacidoza v odsotnosti hipoksemije, anoreksija
English: In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Slovenian: Poleg oportunističnih okužb se vam lahko po začetku jemanja zdravil za zdravljenje okužbe s HIV pojavi kakšna avtoimunska bolezen (to je bolezen, ki nastane, če imunski sistem napade zdrava telesna tkiva).
English: - if you have a very low red blood cell count (anaemia) or a very low white blood cell count
Slovenian: - če imate zelo nizko število rdečih krvnih celic (anemija) ali zelo nizko število belih krvnih celic (nevtropenija).
English: Osteonecrosis: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Osteonekroza: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART - combination antiretroviral therapy) ali obojim.
English: The adverse reactions considered at least possibly related to the treatment are listed below by body system, organ class and absolute frequency.
Slovenian: V nadaljevanju navajamo neželene učinke, za katere obstaja vsaj najmanjša možnost, da so povezani z zdravljenjem s to učinkovino; razvrščeni so po telesnih sistemih, vrsti organa in po absolutni pogostnosti.
English: These occurred more frequently at higher dosages (1200-1500 mg/day) and in patients with advanced HIV disease (especially when there is poor bone marrow reserve prior to treatment), and particularly in patients with CD4 cell counts less than 100/mm
Slovenian: Pogosteje so se pojavile pri dajanju višjih odmerkov (1200-1500 mg/dan) in pri bolnikih v napredovalem obdobju bolezni (zlasti če so imeli že pred začetkom zdravljenja zmanjšano zalogo kostnega mozga), še posebej pa pri bolnikih, pri katerih je bilo število celic CD4 manjše od 100/mm
English: Some clinical findings also support a possible interaction between lamivudine and cladribine
Slovenian: Tudi nekatere klinične ugotovitve potrjujejo možno medsebojno delovanje med lamivudinom in kladribinom.
English: Zidovudine is well absorbed from the gut and at all dose levels studied in adults and children, the bioavailability was between 60-74 % with a mean of 65 %.
Slovenian: Biološka uporabnost se je pri vseh proučevanih odmerkih pri odraslih in otrocih gibala v razponu od 60 do 74 %, srednja vrednost je bila 65 %.
English: Clinical end-point data indicate that lamivudine in combination with zidovudine, results in a significant reduction in the risk of disease progression and mortality.
Slovenian: Rezultati kažejo, da lamivudin v kombinaciji z zidovudinom signifikantno zmanjšuje tveganje za napredovanje bolezni in smrtnost.
English: Old infections may flare up
Slovenian: Možnost ponovnega zagona starih okužb
English: • breakdown of muscle tissue
Slovenian: • razgradnja mišičnega tkiva,
English: If Lamivudine/Zidovudine Teva is discontinued in patients co-infected with hepatitis B virus, periodic monitoring of both liver function tests and markers of HBV replication for 4 months is recommended, as withdrawal of lamivudine may result in an acute exacerbation of hepatitis.
Slovenian: Če pri bolnikih, ki so sočasno okuženi z virusom hepatitisa B, zdravilo Lamivudin/zidovudin Teva ukinemo, je potrebno 4 mesece periodično spremljati tako teste jetrne funkcije kot označevalce replikacije virusa HBV, saj lahko ukinitev lamivudina vodi v akutno poslabšanje hepatitisa.
English: As only limited data are available the clinical significance is not known.
Slovenian: Zaradi maloštevilnih podatkov klinična pomembnost ni znana.
English: Lamivudine/Zidovudine Teva helps to control your condition.
Slovenian: Zdravilo Lamivudin/zidovudin Teva pomaga obvladovati vašo bolezen.
English: The relationship between in vitro susceptibility of HIV to lamivudine and zidovudine and clinical response to lamivudine/zidovudine containing therapy remains under investigation.
Slovenian: Odnos med in vitro občutljivostjo virusa HIV na lamivudin in zidovudin ter kliničnim odzivom na zdravljenje z lamivudinom/zidovudinom še preučujejo.
English: When these signs occur, Lamivudine/Zidovudine Teva should be stopped and your HIV treatment changed.
Slovenian: Če se pojavijo ti znaki, je treba zdravljenje z zdravilom Lamivudin/zidovudin Teva prekiniti in spremeniti zdravljenje okužbe z virusom HIV.
English: Zidovudine was also incorporated into DNA from cord blood leukocytes of infants from zidovudine-treated mothers.
Slovenian: Zidovudin se je vgradil tudi v DNA levkocitov iz popkovnice otrok, katerih matere so zdravili z zidovudinom.
English: Talk to your doctor if any of these apply to you.
Slovenian: Posvetujte se z vašim zdravnikom, če kaj od tega velja za vas.
English: Intravenous studies with lamivudine and zidovudine showed that the mean apparent volume of distribution is 1.3 and 1.6 l/kg respectively.
Slovenian: Raziskave intravenskega lamivudina in zidovudina so pokazale, da znaša njun srednji navidezni volumen porazdelitve 1,3 l/kg za lamivudin oziroma 1,6 l/kg za zidovudin.
English: Uncommon: Transient rises in liver enzymes (AST, ALT) Rare: Hepatitis
Slovenian: Občasni: prehodno zvišane ravni jetrnih encimov (AST, ALT) Redki: hepatitis
English: ANTI-INFECTIVE PRODUCTS
Slovenian: ANTIINFEKTIVNA ZDRAVILA
English: A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALEC(IZDELOVALCI), ODGOVOREN (ODGOVORNI) ZA SPROŠČANJE
English: Do not use this medicine after the expiry date which is stated on the container or carton and blister after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na vsebniku ali škatli in pretisnem omotu poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: For more details physicians should refer to the individual prescribing information for lamivudine and zidovudine.
Slovenian: Podrobnejši podatki so v posameznih navodilih za predpisovanje lamivudina in zidovudina.
English: Some people taking Lamivudine/Zidovudine Teva develop a condition called lactic acidosis, together with an enlarged liver.
Slovenian: Pri nekaterih ljudeh, ki jemljejo zdravilo Lamivudin/zidovudin Teva, se lahko razvije stanje, ki se imenuje laktacidoza, skupaj s povečanjem jeter.
English: • medicines (usually liquids) containing sorbitol and other sugar alcohols (such as xylitol, mannitol, lactitol or maltitol), if taken regularly.
Slovenian: • redna uporaba zdravil (večinoma raztopine), ki vsebujejo sorbitol ali druge sladkorne alkohole (npr. ksilitol, manitol, laktitol, maltitol);
English: When possible, avoid chronic coadministration of Lamivudine/Zidovudine Teva with medicinal products containing sorbitol or other osmotic acting poly-alcohols or monosaccharide alcohols (e.g. xylitol, mannitol, lactitol, maltitol).
Slovenian: Če je mogoče, se izognite kronični sočasni uporabi zdravila Lamivudine/zidovudin Teva z zdravili, ki vsebujejo sorbitol ali druge osmotsko delujoče polialkohole oziroma monosahardine alkohole (npr. ksilitol, manitol, laktitol,
English: Common: Raised blood levels of liver enzymes and bilirubin Rare : Liver disorders such as severe hepatomegaly with steatosis
Slovenian: Pogosti: zvišane ravni jetrnih encimov in bilirubina v krvi Redki: obolenja jeter, kot npr. huda hepatomegalija s steatozo
English: • fluconazole or flucytosine, to treat fungal infections such as candida
Slovenian: • flukonazol ali flucitozin, za zdravljenje glivičnih okužb, kot je kandida;
English: Lamivudine/Zidovudine Teva tablets should not be used for children weighing less than 14 kg, since doses cannot be appropriately adjusted for the weight of the child.
Slovenian: Pri otrocih s telesno maso manjšo od 14 kg se Lamivudin/zidovudin Teva tablet ne sme uporabljati, saj pri teh otrocih odmerka ni možno ustrezno prilagoditi otrokovi telesni masi.
English: • ribavirin or injections of ganciclovir to treat viral infections
Slovenian: • ribavirin ali injekcije s ganciklovirjem za zdravljenje virusnih okužb;
English: Both of these belong to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Slovenian: Obe sodita v skupino protiretrovirusnih zdravil, ki se imenuje zaviralci nukleozidne reverzne transkriptaze (ZNRT).
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment.
Slovenian: V okviru imunske reaktivacije je bil opisan tudi pojav avtoimunskih bolezni (npr. pojav Gravesove bolezni in avtoimunski hepatitis), toda opisani čas do začetka je bolj spremenljiv in ti dogodki se lahko pojavijo veliko mesecev po uvedbi zdravljenja.
English: A small amount of the ingredients in Lamivudine/Zidovudine Teva can also pass into your breastmilk.
Slovenian: Majhna količina sestavin zdravila Lamivudin/zidovudin Teva lahko prehaja v materino mleko.
English: Cross-resistance conferred by the M184V RT is limited within the nucleoside inhibitor class of antiretroviral agents.
Slovenian: Navzkrižna odpornost, ki jo prenaša M184V RT, je omejena na skupino protiretrovirusnih učinkovin,
English: Lactic acidosis is caused by a build up of lactic acid in the body.
Slovenian: Laktacidoza se pojavi zaradi povečanja koncentracije mlečne kisline v telesu.
English: • pyrimethamine, to treat malaria and other parasitic infections
Slovenian: • pirimetamin za zdravljenje malarije in ostalih okužb z zajedalci;
English: Data obtained in patients with moderate to severe hepatic impairment show that lamivudine pharmacokinetics are not significantly affected by hepatic dysfunction.
Slovenian: Podatki pridobljeni pri bolnikih z zmerno do hudo jetrno okvaro kažejo, da jetrna disfunkcija na farmakokinetične lastnosti lamivudina znatneje ne vpliva.
English: There were no other zidovudine-related tumours observed in either sex of either species.
Slovenian: Pri obeh vrstah živali obeh spolov niso opazili drugih z zidovudinom povezanih tumorjev.
English: See your doctor as soon as possible.
Slovenian: se čimprej posvetujte z vašim zdravnikom.
English: Two patterns of multi-drug resistance mutations, the first characterised by mutations in the HIV reverse transcriptase at codons 62, 75, 77, 116 and 151 and the second involving a T69S mutation plus a 6-base pair insert at the same position, result in phenotypic resistance to AZT as well as to the other approved NRTIs.
Slovenian: Pri navzkrižni rezistenci na več zdravil opažamo dva vzorca mutacij, ki imata za posledico fenotipsko odpornost na AZT (zidovudin), pa tudi na druge NRTI: za prvega so značilne mutacije reverzne transkriptaze virusa HIV na kodonih 62, 75, 77, 116 in 151, drugi pa je povezan z mutacijo T69S in vrivanjem 6-baznih parov na istem položaju.
English: Following single dose lamivudine/zidovudine administration in healthy volunteers, mean (CV) lamivudine and zidovudine Cmax values were 1.6 µg/ml (32 %) and 2.0 µg/ml (40 %), respectively and the corresponding values for AUC were 6.1 µg h/ml (20 %) and 2.4 µg h/ml (29 %) respectively.
Slovenian: Po zaužitju enkratnega odmerka zdravila Lamivudin/zidovudin Teva so pri zdravih prostovoljcih srednje (CV) vrednosti Cmax lamivudina znašale 1,6 μg/ml (32 %) in zidovudina 2,0 μg/ml (40 %), pripadajoče vrednosti površine pod krivuljo (AUC) pa so bile 6,1 μg h/ml (20 %) oziroma 2,4 μg h/ml
English: Zidovudine AUC ↑33% Atovaquone AUC ↔
Slovenian: AUC zidovudina ↑33% AUC atovakona ↔
English: When such development is found, treatment with Lamivudine/Zidovudine Teva should not be continued (see section 4.4).
Slovenian: V primeru razvoja lipoatrofije se ne sme nadaljevati zdravljenja z zdravilom Lamivudine/Zidovudine Teva (glejte poglavje 4.4).
English: Lamivudine/Zidovudine Teva and similar medicines may cause side effects in unborn babies.
Slovenian: Zdravilo Lamivudin/zidovudin Teva in podobna zdravila lahko povzročijo neželene učinke pri nerojenemu otroku.
English: Lamivudine is predominately cleared unchanged by renal excretion.
Slovenian: Lamivudin se v glavnem izloča preko ledvic v nespremenjeni obliki.
English: In oral carcinogenicity studies with zidovudine in mice and rats, late appearing vaginal epithelial tumours were observed.
Slovenian: V raziskavah karcinogenosti peroralne uporabe zidovudina na miših in podganah so opazili pozni pojav tumorjev vaginalnega epitela.
English: Patients co-infected with hepatitis C virus: The concomitant use of ribavirin with zidovudine is not recommended due to an increased risk of anaemia (see section 4.5).
Slovenian: Bolniki, sočasno okuženi z virusom hepatitisa C: Zaradi večjega tveganja za pojav anemije sočasne uporabe ribavirina in zidovudina ne priporočamo (glejte poglavje 4.5).
English: Other medicines and Lamivudine/Zidovudine Teva Tell your doctor or pharmacist if you're taking any other medicines, or if you have taken any recently, including herbal medicines or other medicines you bought without a prescription.
Slovenian: Povejte svojemu zdravniku ali farmacevtu, če jemljete katera druga zdravila, ali ste jih pred kratkim jemali, vključno z zdravili rastlinskega izvora ali drugimi zdravili, ki ste jih kupili brez recepta.
English: Patients should be regularly assessed for signs of lipoatrophy during therapy with zidovudine and zidovudine-containing products.
Slovenian: Bolnike je treba med zdravljenjem z zidovudinom in zdravili, ki vsebujejo zidovudin redno ocenjevati glede znakov lipoatrofije.
English: Keep in touch with your doctor, and do not stop taking Lamivudine/Zidovudine Teva without your doctor's advice.
Slovenian: Bodite v stiku z vašim zdravnikom in ne prenehajte jemati zdravila Lamivudin/zidovudin
English: Treatment related findings were limited to lateoccurring vaginal epithelial tumours, which were seen with a similar incidence and time of onset as in the standard oral carcinogenicity study.
Slovenian: Edine posledice uživanja zdravila so bili pozno nastali tumorji vaginalnega epitela, ki so se pojavljali približno enako pogosto in ob enakem času kot tumorji v standardni raziskavi peroralne karcinogenosti.
English: Lamivudine/Zidovudine Teva contains two active ingredients that are used to treat HIV infection: lamivudine and zidovudine.
Slovenian: Zdravilo Lamivudin/zidovudin Teva vsebuje dve zdravilni učinkovini, ki se uporabljata za zdravljenje okužb s HIV: lamivudin in zidovudin.
English: Active renal secretion of lamivudine in the urine is mediated through organic cation transporters (OCTs); co-administration of lamivudine with OCT inhibitors or nephrotoxic drugs may increase lamivudine exposure.
Slovenian: Aktivno ledvično izločanje lamivudina v urinu posredujejo organski kationski transporterji; sočasna uporaba lamivudina z zaviralci teh transporterjev ali z nefrotoksičnimi zdravili lahko poveča izpostavljenost lamivudinu.
English: A transplacental genotoxicity study conducted in monkeys compared zidovudine alone with the combination of zidovudine and lamivudine at humanequivalent exposures.
Slovenian: V raziskavah genotoksičnosti preko placente so na opicah primerjali zidovudin sam s kombinacijo zidovudina in lamivudina v odmerkih, kakršnim so izpostavljeni ljudje.
English: Read the information ‘Other possible side effects of combination therapy for HIV' in Section 4 of this leaflet.
Slovenian: Preberite dodatne informacije v poglavju 4 »Drugi možni neželeni učinki kombiniranega zdravljenja okužbe s HIV« v tem navodilu.
English: • interferon, to treat viral infections
Slovenian: • interferon za zdravljenje virusnih okužb;
English: In these cases the physician should refer to the individual prescribing information for these medicinal products.
Slovenian: V takšnih primerih mora zdravnik pri predpisovanju upoštevati podatke za vsako posamezno zdravilo.
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breastfed infants of mothers treated for HIV are very low (< 4% of maternal serum concentrations) and progressively decrease to undetectable levels when breastfed infants reach 24 weeks of age.
Slovenian: Glede na podatke pri več kot 200 parih mater in otrok, zdravljenih zaradi okužbe HIV, je koncentracija lamivudina v serumu dojenčkov mater, zdravljenih zaradi okužbe s HIV, zelo majhna (manj kot 4 %
English: In general, lamivudine pharmacokinetics in paediatric patients are similar to adults.
Slovenian: Pri otrocih je farmakokinetika lamivudina na splošno podobna kot pri odraslih.
English: For patients co-infected with hepatitis who are being treated with lamivudine containing medicinal products such as Lamivudine/Zidovudine Teva and subsequently become pregnant, consideration should be given to the possibility of a recurrence of hepatitis on discontinuation of lamivudine.
Slovenian: Pri bolnicah, ki so hkrati okužene s hepatitisom, in prejemajo zdravilo, ki vsebuje lamivudin, npr. zdravilo Lamivudin/zidovudin Teva ter zanosijo, je treba upoštevati možnost ponovitve hepatitisa po prenehanju uporabe lamivudina.
English: Zidovudine AUC ↑43% Methadone AUC ↔
Slovenian: AUC zidovudina ↑43% AUC metadona ↔
English: • numbness or weakness in the limbs
Slovenian: • otrplost ali šibkost udov,
English: Cimetidine eliminated only in part by renal organic cation transport system.
Slovenian: Cimetidin se le delno odstrani z ledvičnim organskim kationskim transportnim sistemom.
English: If you take more Lamivudine/Zidovudine Teva than you should
Slovenian: Če ste vzeli večji odmerek zdravila Lamivudin/zidovudin Teva, kot bi smeli
English: Treatment with zidovudine should be discontinued if there is symptomatic hyperlactatemia and metabolic/lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.
Slovenian: V primeru simptomatske hiperlaktatemije in metabolične acidoze/laktacidoze, progresivne hepatomegalije ali hitrega zviševanja ravni aminotransferaz je treba zdravljenje z zidovudinom prekiniti.
English: • fits (convulsions)
Slovenian: • napadi krčev (konvulzije),
English: In reproductive toxicity studies lamivudine has demonstrated evidence of causing an increase in early embryonic deaths in the rabbit at relatively low systemic exposures, comparable to those achieved in man, but not in the rat even at very high systemic exposure.
Slovenian: Raziskave reproduktivne toksičnosti, v katerih so dajali lamivudin brejim kunčicam, so že v relativno nizkih sistemskih koncentracijah, primerljivih s tistimi, ki jih dosegamo pri človeku, pokazale zvišano število zgodnjih smrti zarodkov, v nasprotju s podganami, kjer ni bilo zvišanja celo pri zelo visoki sistemski izpostavljenosti.
English: The mean systemic clearance of lamivudine is approximately 0.32 l/h/kg, with predominantly renal clearance (>70 %) via the organic cationic transport system.
Slovenian: Srednja vrednost sistemskega očistka lamivudina je približno 0,32 l/h/kg, pri čemer glavni delež odpade na ledvični očistek (>70 %),