FrancophonIA/ELRC3.0 huggingface dataset:
English: The Committee recommended that Novaquin be approved for use in the EU.
Slovenian: Priporočil je, da se zdravilo Novaquin odobri za uporabo v EU.
English: What is the withdrawal period in food-producing animals?
Slovenian: Kako dolgo traja karenca pri živalih za proizvodnjo hrane?
English: Other information about Novaquin
Slovenian: Druge informacije o zdravilu Novaquin
English: The withdrawal period for meat from horses treated with Novaquin is three days.
Slovenian: Karenca za meso konj, zdravljenih z zdravilom Novaquin, je tri dni.
English: Novaquin is a veterinary medicine used for the alleviation of inflammation and relief of pain and chronic musculoskeletal disorders (disorders affecting the muscle and bones) in horses.
Slovenian: Novaquin je veterinarsko zdravilo, ki se uporablja za umirjanje vnetja in lajšanje bolečine ter pri kroničnih mišično-skeletnih obolenjih (obolenja, ki prizadenejo mišice in kosti) pri konjih.
English: It is not intended to provide practical advice on how to use Novaquin.
Slovenian: Povzetek ni namenjen zagotavljanju praktičnih nasvetov o njegovi uporabi.
English: Novaquin is available as a 15 mg/ml oral suspension and can only be obtained with a prescription.
Slovenian: Zdravilo Novaquin je na voljo v obliki 15 mg/ml peroralne suspenzije in se izdaja le na recept.
English: Novaquin is a ‘generic medicine'.
Slovenian: Zdravilo Novaquin je „generično zdravilo“.
English: The Agency's Committee for Medicinal Products for Veterinary Use (CVMP) concluded that, in accordance with EU requirements, Novaquin has been shown to have comparable quality and to be bioequivalent to Metacam.
Slovenian: Odbor za zdravila za uporabo v veterinarski medicini (CVMP) pri agenciji je zaključil, da je bilo v skladu z zahtevami EU dokazano, da ima zdravilo Novaquin primerljivo raven kakovosti kot zdravilo Metacam ter da mu je biološko enakovredno.
English: This means that Novaquin is similar to a ‘reference medicine' already authorised in the European Union (EU) called Metacam.
Slovenian: To pomeni, da je podobno referenčnemu zdravilu, ki je že odobreno v Evropski uniji (EU), in sicer zdravilu Metacam.
English: As prostaglandins are substances that trigger inflammation, pain, exudation (fluid that leaks out of blood vessels during inflammation) and fever, meloxicam reduces these signs of disease.
Slovenian: Prostaglandini so snovi, ki sprožajo vnetje, bolečino in izcejanje tekočine (izcejanje tekočine iz krvnih žil med vnetnim procesom) ter povišano telesno temperaturo, meloksikam pa te bolezenske znake zmanjšuje.
English: The precautions are the same as for the reference medicine since Novaquin is a generic medicine.
Slovenian: Previdnostni ukrepi so enaki kot pri referenčnemu zdravilu, saj je zdravilo Novaquin generično zdravilo.
English: It contains the active substance meloxicam.
Slovenian: Vsebuje zdravilno učinkovino meloksikam.
English: Because Novaquin is a generic medicine and is bioequivalent to the reference medicine, its benefits and risks are taken as being the same as the reference medicine's.
Slovenian: Ker je zdravilo Novaquin generično zdravilo in je biološko enakovredno referenčnemu zdravilu, se šteje, da so njegove koristi in tveganja enaki kot pri referenčnem zdravilu.
English: Novaquin contains meloxicam, which belongs to a class of medicines called non-steroidal antiinflammatory drugs (NSAIDs).
Slovenian: Zdravilo Novaquin vsebuje meloksikam, ki spada v skupino zdravil, ki jim pravimo nesteroidna protivnetna zdravila (NSAID).
English: For more information about treatment with Novaquin, read the package leaflet (also part of the EPAR) or contact your veterinarian or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Novaquin preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z veterinarjem ali farmacevtom.
English: What is Novaquin and what is it used for?
Slovenian: Kaj je zdravilo Novaquin in za kaj se uporablja?
English: It is also the time required after administration of a medicine before milk or eggs may be used for human consumption.
Slovenian: Pomeni tudi čas, ki mora preteči po dajanju zdravila, preden se lahko mleko ali jajca uporabijo za prehrano ljudi.
English: Because Novaquin is a generic medicine, studies in animals have been limited to tests to determine that it is bioequivalent to the reference medicine, Metacam.
Slovenian: Ker je zdravilo Novaquin generično zdravilo, so bile študije pri živalih omejene na preskuse za ugotavljanje, ali je biološko enakovredno referenčnemu zdravilu Metacam.
English: Why is Novaquin approved?
Slovenian: Zakaj je bilo zdravilo Novaquin odobreno?
English: For practical information about using Novaquin, animal owners or keepers should read the package leaflet or contact their veterinarian or pharmacist.
Slovenian: Za praktične informacije o uporabi zdravila Novaquin naj lastniki ali skrbniki živali preberejo navodilo za uporabo ali se posvetujejo z veterinarjem ali farmacevtom.
English: Meloxicam
Slovenian: Novaquin meloksikam
English: Therefore, the CVMP's view was that, as for Metacam, the benefits outweigh the identified risks.
Slovenian: Zato je menil, da njegove koristi enako kot pri zdravilu Metacam odtehtajo znana tveganja.
English: Safety information has been included in the summary of product characteristics and the package leaflet for Novaquin, including the precautions to be followed by healthcare professionals and animal owners or keepers.
Slovenian: V povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo so bile vključene informacije o varnosti, vključno s previdnostnimi ukrepi, ki jih morajo upoštevati zdravstveni delavci in lastniki ali skrbniki živali.
English: How does Novaquin work?
Slovenian: Kako zdravilo Novaquin deluje?
English: How is Novaquin used?
Slovenian: Kako se zdravilo Novaquin uporablja?
English: How has Novaquin been studied?
Slovenian: Kako je bilo zdravilo Novaquin raziskano?
English: Ελλάδα ΦΑΡΜΑΣΕΡΒ-ΛΙΛΛΥ Α.Ε.Β.Ε.
Slovenian: ΦΑΡΜΑΣΕΡΒ-ΛΙΛΛΥ Α.Ε.Β.Ε.
English: Date of first authorisation: 27 September 2018
Slovenian: Datum prve odobritve: 27. september 2018
English: - The other ingredients in this medicine are:
Slovenian: - Druge sestavine tega zdravila so:
English: A risk to newborns/infants cannot be excluded.
Slovenian: Tveganja za dojenega novorojenca/otroka ne moremo izključiti.
English: Drink plenty of fluids.
Slovenian: Pijte veliko tekočine.
English: Medical treatment may be necessary.
Slovenian: Mogoče bo potrebno zdravljenje.
English: In animal studies, no effects on female reproductive organs were observed.
Slovenian: V študijah na živalih niso opazili učinkov na ženske reproduktivne organe.
English: General supportive care should be provided.
Slovenian: Treba je poskrbeti za splošno podporno oskrbo.
English: Grade 2 that persists or recurs after resuming the same dose despite maximal supportive measures
Slovenian: Stopnja 2, ki vztraja ali se ponovi po ponovnem začetku jemanja enakega odmerka kljub maksimalnim podpornim ukrepom
English: Do not use this medicine if you notice that the pack is damaged or shows signs of tampering.
Slovenian: Ne uporabljajte tega zdravila, če opazite, da je pakiranje poškodovano ali kaže znake odpiranja.
English: Swallow the tablet whole with a glass of water.
Slovenian: Tableto zaužijte celo s kozarcem vode.
English: Visceral crisis
Slovenian: Visceralna kriza
English: • Decreased appetite
Slovenian: • zmanjšanje apetita
English: Complete or partial recovery was observed for all target organs at the end of the 28-day recovery period.
Slovenian: Na koncu 28-dnevnega obdobja okrevanja so pri vseh ciljnih organih opazili popolno ali delno okrevanje.
English: Management of some adverse reactions may require dose interruption and/or dose reduction as shown in Tables 1-5.
Slovenian: Obvladovanje nekaterih neželenih učinkov lahko zahteva prekinitev in/ali zmanjšanje odmerka, kot je prikazano v preglednicah 1-5.
English: de la Industria, 30 28108 Alcobendas, Madrid Spain
Slovenian: de la Industria 30, 28108 Alcobendas, Madrid, Španija
English: Diarrhoea can be associated with dehydration.
Slovenian: Driska je lahko povezana z dehidracijo.
English: • medicines that may increase the concentration of Verzenios in the blood:
Slovenian: • zdravila, ki lahko povečajo koncentracijo zdravila Verzenios v krvi:
English: These changes were not considered to be clinically relevant.
Slovenian: Te spremembe niso bile ocenjene kot klinično pomembne.
English: Incidence was greatest during the first month of abemaciclib treatment and was lower subsequently.
Slovenian: Pojavnost je bila največja v prvem mesecu zdravljenja z abemaciklibom, nato pa se je zmanjšala.
English: See section 4 “Possible side effects”, and talk to your doctor if you have any symptoms.
Slovenian: Glejte poglavje 4 »Možni neželeni učinki« in se posvetujte z zdravnikom, če se pri vas pojavijo kakršni koli simptomi.
English: LLN = lower limit of normal
Slovenian: SMN = spodnja meja normalne vrednosti
English: The dose can be taken with or without food.
Slovenian: Odmerek se lahko vzame s hrano ali brez nje.
English: Avoid grapefruit or grapefruit juice.
Slovenian: Izogibajte se grenivki ali grenivkinemu soku.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: • ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do precejšnje spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: - if you are allergic to abemaciclib or any of the other ingredients of this medicine (listed in section 6).
Slovenian: - če ste alergični na abemaciklib ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: If you feel unusually tired or dizzy, take special care when driving or using machines.
Slovenian: Če se počutite neobičajno utrujeni ali omotični, bodite pri upravljanju vozil in strojev posebno previdni.
English: This was not considered to be clinically relevant.
Slovenian: To ni bilo ocenjeno kot klinično pomembno.
English: Toxicitya, b
Slovenian: Toksičnosta, b
English: Patients should take the doses at approximately the same times every day.
Slovenian: Bolnice naj odmerke vzamejo vsak dan ob približno istem času.
English: Grade 3, recurrent; or Grade 4
Slovenian: Stopnja 3, ponavljajoča se, ali stopnja 4
English: These could be a sign of low white blood cell counts (which may affect more than 1 in 10 people) and should be treated immediately.
Slovenian: To je lahko znak zmanjšanega števila belih krvnih celic (ki se lahko pojavi pri več kot 1 od 10 bolnikov) in ga je treba takoj zdraviti.
English: Therefore, abemaciclib can be taken with or without food.
Slovenian: Abemaciklib se torej lahko jemlje s hrano ali brez nje.
English: The safety and efficacy of abemaciclib in children and adolescents aged less than 18 years has not been established.
Slovenian: Varnost in učinkovitost abemacikliba pri otrocih in mladostnikih, starih manj kot 18 let, še nista bili dokazani.
English: Like all medicines, this medicine can cause side-effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi to zdravilo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Verzenios is not to be used in children and adolescents under 18 years of age.
Slovenian: Zdravilo Verzenios se ne sme uporabljati pri otrocih in mladostnikih, mlajših od 18 let.
English: Fatal events occurred in <1% of patients.
Slovenian: Do primerov s smrtnim izidom je prišlo pri < 1 % bolnic.
English: Specific animal studies to test abemaciclib for carcinogenic potential have not been performed.
Slovenian: Specifičnih študij na živalih, v katerih bi testirali rakotvorni potencial abemacikliba, niso izvedli.
English: Grade 3 or 4 a NCI CTCAE
Slovenian: Stopnja 3 ali 4 a NCI CTCAE
English: You can take the tablets either with or without food, just avoid grapefruit and grapefruit juice (see section 2 “Verzenios with food and drink”).
Slovenian: Tablete lahko jemljete s hrano ali brez nje, izogibajte se le grenivki in grenivkinemu soku (glejte poglavje 2 »Zdravilo Verzenios skupaj s hrano in pijačo«).
English: Febrile neutropenia was reported in 0.9% patients.
Slovenian: O febrilni nevtropeniji so poročali pri 0,9 %
English: • Infections
Slovenian: • okužbe
English: Avoid grapefruit or grapefruit juice while you are taking the medicine as they may increase the concentration of Verzenios in the blood.
Slovenian: Med jemanjem zdravila se izogibajte grenivki ali grenivkinemu soku, saj lahko povečata koncentracijo zdravila Verzenios v krvi.
English: - Painful swollen leg, chest pain, shortness of breath, rapid breathing or rapid heart rate as these can be signs of blood clots in the vein (which may affect up to 1 in 10 people).
Slovenian: - boleča, otekla noga, bolečine v prsnem košu, kratka sapa, hitro dihanje ali hiter srčni utrip, saj so to lahko znaki krvnih strdkov v venah (ki se lahko pojavijo pri 1 od 10 bolnikov);
English: Dose reduction is not required.
Slovenian: Zmanjšanje odmerka ni potrebno.
English: Age, gender, and body weight
Slovenian: Starost, spol in telesna masa
English: It is currently unknown whether abemaciclib may reduce the effectiveness of systemically acting hormonal contraceptives.
Slovenian: Ni verjetno da bi abemaciklib lahko zmanjšal učinkovitost sistemsko delujočih hormonskih kontraceptivov.
English: Blocking the action of these proteins can slow down growth of cancer cells, shrink the tumour and delay progression of the cancer.
Slovenian: Zaviranje delovanja teh proteinov lahko upočasni rast rakavih celic, zmanjša velikost tumorja in upočasni napredovanje raka.
English: The effect of abemaciclib on fertility in humans is unknown.
Slovenian: Učinek abemacikliba na plodnost pri človeku ni znan.
English: If you take more Verzenios than you should
Slovenian: Če ste vzeli več zdravila Verzenios, kot bi smeli
English: The half-life of abemaciclib increased from 24 to 55 hours (see section 4.2).
Slovenian: Razpolovni čas abemacikliba se je podaljšal od 24 na 55 ur (glejte poglavje 4.2).
English: a NCI CTCAE ULN = upper limit of normal
Slovenian: a NCI CTCAE ZMN = zgornja meja normalne vrednosti
English: Resume at next lower dose.
Slovenian: Zdravljenje nadaljujte z naslednjim nižjim odmerkom.
English: The effect of abemaciclib on the QTcF interval was evaluated in 144 patients with advanced cancer.
Slovenian: Elektrofiziologija srca Učinek abemacikliba na interval QTcF so ovrednotili pri 144 bolnicah z napredovalim rakom.
English: Management recommendations
Slovenian: Priporočila za obvladovanje
English: Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Slovenian: V vsaki skupini pogostnosti so neželeni učinki navedeni po padajoči resnosti.
English: Grade 3 or 4 or requires hospitalisation a NCI CTCAE
Slovenian: Stopnja 3 ali 4 ali kadar je potrebna hospitalizacija a NCI CTCAE
English: Resume at next lower dose unless the dose was already reduced for the toxicity that led to the use of the growth factor.
Slovenian: Zdravljenje nadaljujte z naslednjim nižjim odmerkom, razen če je bil odmerek že zmanjšan zaradi toksičnosti, ki je pripeljala do uporabe rastnega faktorja.
English: There are no data on the efficacy and safety of abemaciclib in patients with visceral crisis.
Slovenian: Ni podatkov o učinkovitosti in varnost abemacikliba pri bolnicah z visceralno krizo.
English: The tablet should be swallowed whole (patients should not chew, crush, or split tablets before swallowing).
Slovenian: Tableto je treba zaužiti celo (bolnice je pred zaužitjem ne smejo gristi, drobiti ali deliti).
English: Verzenios with food and drink
Slovenian: Zdravilo Verzenios skupaj s hrano in pijačo
English: • Reduction in white blood cells, red blood cells, and blood platelets
Slovenian: • zmanjšano število belih krvnih celic, rdečih krvnih celic in trombocitov
English: Objective response for patients with measurable diseasea
Slovenian: Objektivni odziv pri bolnicah z merljivo boleznijoa
English: Clinical benefit ratec (measurable disease)
Slovenian: Stopnja klinične koristic (merljiva bolezen)
English: Verzenios may: - reduce the number of your white blood cells, and you may be at greater risk of getting an infection.
Slovenian: Zdravilo Verzenios lahko: - zniža število belih krvnih celic, zato se lahko zveča tveganje za okužbo.
English: What Verzenios is and what it is used for What you need to know before you take Verzenios How to take Verzenios
Slovenian: Kaj je zdravilo Verzenios in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Verzenios Kako jemati zdravilo Verzenios
English: Verzenios should be taken continuously as long as the patient is deriving clinical benefit from therapy or until unacceptable toxicity occurs.
Slovenian: Zdravilo Verzenios je treba jemati, dokler ima bolnica od zdravljenja klinično korist ali do pojava nesprejemljive toksičnosti.
English: There are no data from the use of abemaciclib in pregnant women.
Slovenian: Podatkov o uporabi abemacikliba pri nosečnicah ni.
English: If you take too many tablets, or if someone else takes your medicine, contact a doctor or hospital for advice.
Slovenian: Če ste vzeli preveč tablet ali če je nekdo drug vzel vaše zdravilo, se za nasvet obrnite na zdravnika ali bolnišnico.
English: In particular, tell you doctor or pharmacist before taking Verzenios if you are taking the following:
Slovenian: Še zlasti morate zdravnika ali farmacevta pred jemanjem zdravila Verzenios obvestiti, če jemljete naslednja zdravila:
English: The most commonly occurring adverse reactions are diarrhoea, infections, neutropenia, anaemia, fatigue, nausea, vomiting and decreased appetite.
Slovenian: Najpogostejši neželeni učinki so driska, okužbe, nevtropenija, anemija, utrujenost, slabost, bruhanje in zmanjšanje apetita.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency: http://www.ema.europa.eu
Slovenian: Podrobne informacije o tem zdravilu so na voljo na spletni strani Evropske agencije za zdravila: http://www.ema.europa.eu
English: Approximately 25% of patients had primary endocrine resistance (progression on endocrine therapy within the first 2 years of adjuvant endocrine therapy or within the first 6 months of first line endocrine therapy for metastatic breast cancer) and for the majority, endocrine resistance developed later.
Slovenian: Približno 25 % bolnic je imelo primarno endokrino odpornost (napredovanje ob endokrinem zdravljenju v prvih 2 letih adjuvantnega endokrinega zdravljenja ali v prvih 6 mesecih od uvedbe endokrinega zdravljenja kot prve linije zdravljenja metastatskega raka dojke), pri večini pa se je endokrina odpornost razvila kasneje.
English: Mild and moderate renal impairment had no effect on the exposure of abemaciclib.
Slovenian: Blaga in zmerna ledvična okvara nista imeli učinka na izpostavljenost abemaciklibu.
English: Patient requires administration of blood cell growth factors
Slovenian: Bolnica potrebuje zdravljenje z rastnimi faktorji za krvne celice
English: These circulating metabolites are active with similar potency to abemaciclib.
Slovenian: Ti krožeči presnovki so aktivni s podobno močjo kot abemaciklib.
English: The geometric mean systemic volume of distribution is approximately 750 L (69% CV), indicating distribution of abemaciclib into tissues.
Slovenian: Geometrijska sredina sistemskega volumna distribucije je približno 750 l (69 % CV), kar kaže, da se abemaciklib porazdeli v tkiva.
English: In each treatment arm the majority of patients were white, and had not received chemotherapy for metastatic disease.
Slovenian: V vsaki skupini zdravljenja je bila večina bolnic belopoltih in pred tem niso prejemale kemoterapije zaradi metastatske bolezni.
English: Abemaciclib blocks the effects of proteins called cyclin-dependent kinase 4 and 6.
Slovenian: Abemaciklib zavira učinke proteinov, imenovanih od ciklina odvisne kinaze 4 in 6.
English: What you need to know before you take Verzenios Do not take Verzenios:
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Verzenios Ne jemljite zdravila Verzenios:
English: Suspend abemaciclib dose for at least 48 hours after the last dose of blood cell growth factors was administered and until toxicity resolves to Grade 2 or less.
Slovenian: Prekinite odmerjanje abemacikliba za vsaj 48 ur po zadnjem odmerku rastnih faktorjev za krvne celice in do izboljšanja toksičnosti na stopnjo 2 ali nižjo.
English: Progression-free survival
Slovenian: Preživetje brez napredovanja
English: Concentrations of abemaciclib and its active metabolites in cerebrospinal fluid are comparable to unbound plasma concentrations.
Slovenian: Koncentracije abemacikliba in njegovih aktivnih presnovkov v cerebrospinalni tekočini so primerljive s koncentracijami nevezanih oblik v plazmi.
English: Management recommendations for non-haematologic toxicities (excluding diarrhoea and increased aminotransferases)
Slovenian: Priporočila za obvladovanje nehematoloških toksičnosti (razen driske in povečanih vrednosti aminotransferaz)
English: In vitro, Rb-negative and Rb-depleted cancer cell lines are generally less sensitive to abemaciclib.
Slovenian: Rb-negativne in Rb-osiromašene rakave celične linije in vitro so na splošno manj občutljive na abemaciklib.
English: Patients should be monitored for signs and symptoms of infection and treated as medically appropriate.
Slovenian: Bolnice je treba spremljati glede znakov in simptomov okužbe ter jih ustrezno zdraviti.
English: Adverse reactions reported in phase 3 studies of abemaciclib in combination with endocrine therapy (N=768)
Slovenian: Neželeni učinki, o katerih so poročali iz študij III. faze z abemaciklibom v kombinaciji z endokrinim zdravljenjem (N = 768)
English: The majority of patients (96%) had metastatic disease at baseline.
Slovenian: Večina bolnic (96 %) je imela ob izhodišču metastatsko bolezen.
English: Patients should be advised to be cautious when driving or using machines in case they experience fatigue or dizziness during treatment with Verzenios (see section 4.8).
Slovenian: Bolnicam je treba svetovati previdnost ob vožnji ali upravljanju strojev, če med zdravljenjem z zdravilom Verzenios opazijo utrujenost in omotico (glejte poglavje 4.8).
English: Management recommendations for haematologic toxicities
Slovenian: Priporočila za obvladovanje hematoloških toksičnosti
English: Abemaciclib absorption is slow, with a Tmax of 8 hours and a mean absolute bioavailability of approximately 45 %.
Slovenian: Absorpcija abemacikliba je počasna, Tmax znaša 8 ur, povprečna absolutna biološka uporabnost pa je približno 45 %.
English: If you have cough, fever and difficulty breathing or chest pain, this could be a sign of lung infection.
Slovenian: Če kašljate, imate povišano telesno temperaturo in težave z dihanjem ali bolečine v prsnem košu, je to lahko znak okužbe pljuč.
English: If toxicity does not resolve within 24 hours to Grade 1 or less, suspend dose until resolution.
Slovenian: Če se toksičnost v 24 urah ne zmanjša na stopnjo 1 ali manj, prekinite odmerjanje do izboljšanja.
English: Persistent or recurrent Grade 2 toxicity that does not resolve with maximal supportive measures to baseline or Grade 1 within 7 days
Slovenian: Trdovratna ali ponavljajoča se toksičnost stopnje 2, ki se tudi z maksimalnimi podpornimi ukrepi v 7 dneh ne izboljša do izhodiščne vrednosti ali stopnje 1.
English: Infections/infestations
Slovenian: Okužbe/infestacije
English: Abemaciclib is highly bound to plasma proteins in humans (mean bound fraction approximately 96% to 98%).
Slovenian: Abemaciklib se pri človeku v veliki meri veže na plazemske beljakovine (povprečna vezana frakcija približno od 96 % do 98 %).