FrancophonIA/ELRC3.0 huggingface dataset:
English: You can usually continue to take other medicines whilst you are being treated with Glidipion.
Slovenian: Po navadi lahko med jemanjem zdravila Glidipion še naprej jemljete tudi druga zdravila.
English: If jaundice is observed, the medicinal product should be discontinued.
Slovenian: Če se pojavi zlatenica, je treba uporabo tega zdravila prekiniti.
English: OTHER (FOR CALENDARISED PACKS SIZES OF 14, 28, 56, 84 AND 98 TABLETS ONLY)
Slovenian: DRUGO (ZA KOLEDARSKA PAKIRANJA - SAMO ZA VELIKOSTI 14, 28, 56, 84 IN 98 TABLET)
English: - hypersensitivity to the active substance or to any of the excipients - cardiac failure or history of cardiac failure (NYHA stages I to IV) - hepatic impairment - diabetic ketoacidosis - current bladder cancer or a history of bladder cancer - uninvestigated macroscopic haematuria.
Slovenian: - preobčutljivost za zdravilno učinkovino ali katerokoli pomožno snov - srčno popuščanje ali anamneza srčnega popuščanja (razredi od I do IV po NYHA) - okvara jeter - diabetična ketoacidoza - rak sečnega mehurja trenutno ali v anamnezi - neraziskana makroskopska hematurija.
English: Other medicines and Glidipion
Slovenian: Drugiha zdravila in zdravilo Glidipion
English: - Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance (see section 4.4).
Slovenian: - Pioglitazon je indiciran tudi za kombinirano zdravljenje z insulinom pri odraslih bolnikih s sladkorno boleznijo tipa 2, ki glikemije nimajo zadostno urejene z insulinom, metformin pa zanje ni primeren zaradi kontraindikacij ali neprenašanja (glejte poglavje 4.4).
English: If you are following a diabetic diet, you should continue with this while you are taking Glidipion.
Slovenian: Če se držite diabetične diete, dieto nadaljujte tudi med jemanjem zdravila Glidipion.
English: • The risk of bladder cancer and relevant risk minimisation advice.
Slovenian: • Tveganju za raka sečnega mehurja in ustreznim nasvetom za zmanjšanje tega tveganja.
English: The fracture incidence calculated was 1.9 fractures per 100 patient years in women treated with pioglitazone and 1.1 fractures per 100 patient years in women treated with a comparator.
Slovenian: Izračunana incidenca zlomov je bila 1,9 zloma na 100 bolnik-let pri ženskah, zdravljenih s pioglitazonom, in 1,1 zloma na 100 bolnik-let pri ženskah, zdravljenih s primerjalnim zdravilom.
English: A clinical trial of pioglitazone vs. gliclazide as monotherapy was extended to two years in order to assess time to treatment failure (defined as appearance of HbA1c ≥ 8.0% after the first six months of therapy).
Slovenian: Klinično preskušanje pioglitazona v primerjavi z gliklazidom kot monoterapijo so podaljšali na dve leti za oceno časa do neuspeha zdravljenja (ta je bil opredeljen kot pojav HbA1c ≥ 8.0 % po prvih šestih mesecih zdravljenja).
English: Since there is a potential for an increase in dose-related adverse events, a decrease in the dose of pioglitazone may be needed when gemfibrozil is concomitantly administered.
Slovenian: Ker obstaja možnost povečanja od odmerka odvisnih neželenih učinkov, utegne biti med sočasno uporabo z gemfibrozilom potrebno zmanjšanje odmerka pioglitazona.
English: Any macroscopic haematuria should be investigated before starting pioglitazone therapy.
Slovenian: Vsako makroskopsko hematurijo je treba raziskati pred začetkom zdravljenja s pioglitazonom.
English: However, the incidences of oedema, weight gain and heart failure were increased.
Slovenian: Toda incidence edemov, povečanja telesne mase in srčnega popuščanja so bile večje.
English: Your doctor will check whether Glidipion is working 3 to 6 months after you start taking it.
Slovenian: Vaš zdravnik bo od 3 do 6 mesecev potem, ko boste začeli jemati zdravilo Glidipion, preveril, ali zdravilo pri vas deluje.
English: If you accidentally take too many tablets, or if someone else or a child takes your medicine, talk to a doctor or pharmacist immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Glidipion, kot bi smeli Če pomotoma vzamete preveč tablet, ali če vaše zdravilo vzame kdo drug ali otrok, se nemudoma posvetujte z zdravnikom ali farmacevtom.
English: Glidipion can be taken with or without food.
Slovenian: Zdravilo Glidipion lahko vzamete s hrano ali brez nje.
English: Studies in man suggest no induction of the main inducible cytochrome P450, 1A, 2C8/9 and 3A4.
Slovenian: Študije pri človeku ne kažejo indukcije glavnih inducibilnih izoencimov citokroma P450 1A, 2C8/9 in 3A4.
English: However, certain medicines are especially likely to affect the amount of sugar in your blood: - gemfibrozil (used to lower cholesterol) - rifampicin (used to treat tuberculosis and other infections) Tell your doctor or pharmacist if you are taking any of these.
Slovenian: A pri nekaterih zdravilih je še posebej verjetno, da vplivajo na količino sladkorja v krvi: - gemfibrozil (uporablja se za znižanje holesterola), - rifampicin (uporablja se za zdravljenje tuberkuloze in drugih okužb).
English: Before you start taking Glidipion you will have a blood sample taken to check your liver function.
Slovenian: Pred začetkom jemanja zdravila Glidipion boste morali opraviti preiskavo krvi za kontrolo delovanja jeter.
English: Inform your doctor as soon as possible if you experience signs of heart failure such as unusual shortness of breath or rapid increase in weight or localised swelling (oedema).
Slovenian: Zdravnika morate čim prej obvestiti, če se vam pojavijo znaki srčnega popuščanja, npr. nenavadno kratka sapa, hitro povečanje telesne mase ali omejeno otekanje (edemi).
English: If any patient develops symptoms suggesting hepatic dysfunction, which may include unexplained nausea, vomiting, abdominal pain, fatigue, anorexia and/or dark urine, liver enzymes should be checked.
Slovenian: Če se pojavijo simptomi, ki nakazujejo moteno delovanje jeter - med takšnimi so lahko nepojasnjena navzea, bruhanje, bolečine v trebuhu, utrujenost, anoreksija in/ali temen urin - je treba preveriti jetrne encime.
English: Close monitoring of glycaemic control should be considered (see section 4.4).
Slovenian: Potrebno je natančno spremljanje urejenosti glikemije (glejte poglavje 4.4).
English: - The other ingredients are lactose monohydrate, hydroxypropylcellulose, carmellose calcium and magnesium stearate.
Slovenian: - Pomožne snovi so: laktoza monohidrat, hidroksipropilceluloza, kalcijev karmelozat in magnezijev stearat.
English: Intrinsic clearance is therefore reduced, coupled with a higher unbound fraction of pioglitazone.
Slovenian: Intrinzični očistek je zato manjši, obenem je delež nevezanega pioglitazona večji.
English: Dietary acidification significantly decreased but did not abolish the incidence of tumours.
Slovenian: Prehransko zakisanje je incidenco tumorjev bistveno zmanjšalo, ni pa je odpravilo.
English: Pioglitazone effects may be mediated by a reduction of insulin resistance.
Slovenian: Mehanizem učinkov pioglitazona je lahko zmanjšanje odpornosti proti insulinu.
English: Immune System Disorders
Slovenian: Bolezni imunskega sistema
English: Co-administration of pioglitazone with sulphonylureas does not appear to affect the pharmacokinetics of the sulphonylurea.
Slovenian: Kot kaže, sočasna uporaba pioglitazona in sulfonilsečnin ne vpliva na farmakokinetiko sulfonilsečnine.
English: Following initiation of therapy with pioglitazone, it is recommended that liver enzymes be monitored periodically based on clinical judgement.
Slovenian: Po začetku zdravljenja s pioglitazonom je priporočljivo jetrne encime kontrolirati redno po klinični presoji.
English: Glidipion contains pioglitazone.
Slovenian: Zdravilo Glidipion vsebuje pioglitazon.
English: Patients receiving pioglitazone had a mean reduction in HbA1c of 0.45% compared with those continuing on insulin alone, and a reduction of insulin dose in the pioglitazone treated group.
Slovenian: Prejemnikom pioglitazona se je HbA1c v povprečju znižal za 0,45 % v primerjavi s tistimi, ki so nadaljevali zdravljenje samo z insulinom, in odmerek insulina se je v skupini zdravljenih s pioglitazonom zmanjšal.
English: Steady state pharmacokinetics are similar in patients age 65 and over and young subjects.
Slovenian: Farmakokinetika v stanju dinamičnega ravnovesja je pri bolnikih, starih 65 let ali več, podobna kot pri mlajših preiskovancih.
English: Common (may affect up to 1 in 10 people) - headache - dizziness - joint pain - impotence - back pain - shortness of breath - small reduction in red blood cell count - flatulence (wind)
Slovenian: Pogosti (pojavijo se lahko pri največ 1 od 10 bolnikov) - glavobol - omotica - bolečine v sklepih - impotenca - bolečine v hrbtu - kratka sapa - rahlo zmanjšanje števila rdečih krvnih celic - napenjanje (vetrovi)
English: 2 Visual disturbance has been reported mainly early in treatment and is related to changes in blood glucose due to temporary alteration in the turgidity and refractive index of the lens as seen with other hypoglycaemic treatments.
Slovenian: O motnjah vida so poročali predvsem zgodaj med zdravljenjem, povezane pa so s spremembami vrednosti glukoze v krvi, in sicer zaradi začasnih sprememb nabreklosti (turgidnosti) in refrakcijskega indeksa leče, kakršne se pojavljajo tudi pri drugih zdravilih za znižanje glikemije.
English: Frequency of adverse reactions of pioglitazone by treatment regimen
Slovenian: Pogostnost neželenih učinkov pioglitazona po shemi zdravljenja
English: The effect of pioglitazone (45 mg monotherapy vs. placebo) was studied in a small 18-week trial in type 2 diabetics.
Slovenian: Vpliv pioglitazona (45 mg v monoterapiji v primerjavi s placebom) so raziskali v majhnem, 18-tedenskem preskušanju pri sladkornih bolnikih tipa 2.
English: What Glidipion is and what it is used for What you need to know before you take Glidipion How to take Glidipion
Slovenian: Kaj je zdravilo Glidipion in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Glidipion Kako jemati zdravilo Glidipion Možni neželeni učinki
English: In clinical trials with pioglitazone there was evidence of dose related weight gain, which may be due to fat accumulation and in some cases associated with fluid retention.
Slovenian: V kliničnih preskušanjih s pioglitazonom so opažali z odmerkom povezano povečanje telesne mase, ki je lahko posledica nabiranja maščob in je v nekaterih primerih povezano z zastajanjem tekočine.
English: Pioglitazone dose adjustment within the recommended posology or changes in diabetic treatment should be considered (see section 4.5).
Slovenian: V poštev pridejo prilagoditev odmerka pioglitazona v okviru priporočenega odmerjanja ali spremembe zdravljenja sladkorne bolezni (glejte poglavje 4.5).
English: as monotherapy
Slovenian: Kot monoterapija
English: Reproductive system and breast disorders erectile dysfunction common
Slovenian: Motnje reprodukcije in dojk erektilna disfunkcija pogosto
English: Fasting and postprandial glycaemic control is improved in patients with type 2 diabetes mellitus.
Slovenian: Urejenost glikemije na tešče in po obrokih se pri bolnikih s sladkorno boleznijo tipa 2 izboljša.
English: It is recommended, therefore, that patients treated with pioglitazone undergo periodic monitoring of liver enzymes.
Slovenian: Zato je bolnikom, zdravljenim s pioglitazonom, priporočljivo redno kontrolirati jetrne encime.
English: In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained (see section 4.4).
Slovenian: Zaradi tveganj, ki so povezana z dolgotrajnim zdravljenjem, morajo zdravniki na nadaljnjih rutinskih pregledih preverjati, da je korist pioglitazona še prisotna (glejte poglavje 4.4).
English: Glidipion helps control the level of sugar in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.
Slovenian: Zdravilo Glidipion pri sladkorni bolezni tipa 2 pomaga obvladati koncentracijo krvnega sladkorja, ker telesu pomaga bolje izrabiti insulin.
English: A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJE
English: In clinical trials with pioglitazone the incidence of elevations of ALT greater than three times the upper limit of normal was equal to placebo but less than that seen in metformin or sulphonylurea comparator groups.
Slovenian: V kliničnih preskušanjih s pioglitazonom je bila incidenca zvišanj ALT na več kot trikratno zgornjo normalno mejo enaka kot pri placebu, a manjša kot v primerjalnih skupinah z metforminom ali sulfonilsečnino.
English: In an outcome study of patients with pre-existing major macrovascular disease, the incidence of serious heart failure was 1.6% higher with pioglitazone than with placebo, when added to therapy that included insulin.
Slovenian: V študiji izidov pri bolnikih z obstoječo hujšo makrovaskularno boleznijo je bila incidenca resnega srčnega popuščanja po dodatku zdravljenju, ki je vključevalo insulin, 1,6 % večja s pioglitazonom kot s placebom.
English: Treatment with pioglitazone has been shown to reduce hepatic glucose output and to increase peripheral glucose disposal in the case of insulin resistance.
Slovenian: Ugotovljeno je, da zdravljenje s pioglitazonom zmanjša sproščanje glukoze iz jeter in poveča periferno odstranjevanje glukoze v primeru odpornosti proti insulinu.
English: Since insulin and pioglitazone are both associated with fluid retention, concomitant administration may increase the risk of oedema.
Slovenian: Tako insulin kot pioglitazon sta povezana z zastajanjem tekočine, zato lahko njuna sočasna uporaba poveča tveganje edemov.
English: The Prescriber Guide should highlight the following:
Slovenian: V vodniku za predpisovanje mora biti poseben poudarek namenjen:
English: Blood and lymphatic system disorders anaemia common
Slovenian: Bolezni krvi in limfatičnega sistema anemija pogosto
English: In patients with renal impairment, plasma concentrations of pioglitazone and its metabolites are lower than those seen in subjects with normal renal function, but oral clearance of parent substance is similar.
Slovenian: Pri bolnikih z okvaro ledvic je koncentracija pioglitazona in njegovih presnovkov v plazmi manjša kot pri preiskovancih z normalnim delovanjem ledvic, a peroralni očistek matične snovi je podoben.
English: Glidipion tablets contain lactose monohydrate and therefore should not be administered to patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
Slovenian: Tablete Glidipion vsebujejo laktoza monohidrat, zato bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze, ne smejo jemati tega zdravila.
English: In comparator groups, addition of sulphonylurea to metformin resulted in a mean weight gain of 1.3 kg and addition of metformin to a sulphonylurea a mean weight loss of 1.0 kg.
Slovenian: V primerjalnih skupinah je dodatek sulfonilsečnine metforminu povzročil povprečno povečanje telesne mase za 1,3 kg in dodatek metformina sulfonilsečnini povprečno zmanjšanje telesne mase za 1,0 kg.
English: It is not known whether pioglitazone is secreted in human milk.
Slovenian: Ni znano, ali se pioglitazon pri človeku izloča v materinem mleku.
English: Mean levels of liver enzymes decreased with treatment with pioglitazone.
Slovenian: Povprečna raven jetrnih encimov se je med zdravljenjem s pioglitazonom znižala.
English: Some patients with long-standing type 2 diabetes mellitus and heart disease or previous stroke who were treated with pioglitazone and insulin experienced the development of heart failure.
Slovenian: Nekaterim bolnikom z dolgotrajno sladkorno boleznijo tipa 2 in boleznijo srca ali predhodno možgansko kapjo, ki so prejemali pioglitazon in insulin, se je pojavilo srčno popuščanje.
English: In combination with insulin, the current insulin dose can be continued upon initiation of pioglitazone therapy.
Slovenian: V kombinaciji z insulinom je mogoče insulin po uvedbi zdravljenja s pioglitazonom nadaljevati v dotlej uporabljanem odmerku.
English: No dose adjustment is necessary in patients with impaired renal function (creatinine clearance > 4 ml/min) (see section 5.2).
Slovenian: Bolnikom z okvarjenim delovanjem ledvic (očistek kreatinina > 4 ml/min) odmerka ni treba prilagoditi (glejte poglavje 5.2).
English: There is no induction of the main inducible P450 isoenzymes 1A, 2C8/9, and 3A4 in man.
Slovenian: Pri človeku ni indukcije glavnih inducibilnih izoencimov P450 1A, 2C8/9 in 3A4.
English: In combination trials pioglitazone added to metformin resulted in mean weight increase over one year of 1.5 kg and added to a sulphonylurea of 2.8 kg.
Slovenian: V kombiniranih preskušanjih zdravljenja je pioglitazon, dodan metforminu, povzročil povprečno povečanje telesne mase v enem letu za 1,5 kg, dodan sulfonilsečnini pa za 2,8 kg.
English: The other side effects that have been experienced by some patients when pioglitazone is taken with other antidiabetic medicines are:
Slovenian: Drugi neželeni učinki, ki so se pojavili nekaterim bolnikom med jemanjem pioglitazona z drugimi zdravili za sladkorno bolezen, so:
English: The improved glycaemic control is associated with a reduction in both fasting and postprandial plasma insulin concentrations.
Slovenian: Boljša urejenost glikemije je povezana z zmanjšanjem koncentracije insulina v plazmi na tešče in po obrokih.
English: 1 Postmarketing reports of hypersensitivity reactions in patients treated with pioglitazone have been reported.
Slovenian: V poročilih po pridobitvi dovoljenja za promet so poročali o preobčutljivostnih reakcijah pri bolnikih zdravljenih s pioglitazonom.
English: Aluminium/aluminium blisters, packs of 14, 28, 30, 50, 56, 84, 90, 98 and 100 tablets.
Slovenian: Aluminijski/aluminijski pretisni omoti, pakiranja s 14, 28, 30, 50, 56, 84, 90, 98 in 100 tabletami.
English: Proportional increases of the plasma concentration were observed for doses from 2-60 mg.
Slovenian: Pri odmerkih od 2 do 60 mg so opazili sorazmerno povečanje koncentracije v plazmi.
English: In PROactive, a cardiovascular outcome study, 5238 patients with type 2 diabetes mellitus and pre-existing major macrovascular disease were randomised to pioglitazone or placebo in addition to existing antidiabetic and cardiovascular therapy, for up to 3.5 years.
Slovenian: V študiji kardiovaskularnih izidov PROactive so 5238 bolnikov s sladkorno boleznijo tipa 2 in obstoječo hudo makrovaskularno boleznijo za obdobje do 3,5 leta randomizirali na pioglitazon ali placebo (oba kot dodatek dotedanjemu antidiabetičnemu in kardiovaskularnemu zdravljenju).
English: Liver enzymes should be checked prior to the initiation of therapy with pioglitazone in all patients.
Slovenian: Jetrne encime je treba pred začetkom zdravljenja s pioglitazonom kontrolirati pri vseh bolnikih.
English: There may be an increased possibility of becoming pregnant because you may ovulate again when you take Glidipion.
Slovenian: Obstaja lahko večja možnost, da zanosite, ker se lahko ob uporabi zdravila Glidipion znova pojavi ovulacija (sprostitev jajčeca).
English: The packs with 14, 28, 56, 84 and 98 tablets contain blisters with abbreviations for days of the week printed on the blister (Mon., Tue., Wed., Thu., Fri., Sat., Sun.).
Slovenian: Pakiranja s 14, 28, 56, 84 in 98 tabletami vsebujejo pretisne omote, na katerih so natisnjene okrajšave za dneve v tednu (PON, TOR, SRE, ČET, PET, SOB, NED).
English: Visceral fat was significantly decreased, while there was an increase in extra-abdominal fat mass.
Slovenian: Visceralno maščevje se je značilno zmanjšalo, masa zunajtrebušnega maščevja pa se je povečala.
English: This was attributable to the action of pioglitazone in diminishing the maternal hyperinsulinaemia and increased insulin resistance that occurs during pregnancy, thereby reducing the availability of metabolic substrates for foetal growth.
Slovenian: To je mogoče pripisati vplivu pioglitazona na zmanjšanje hiperinsulinemije pri materi in večji odpornosti proti insulinu, ki se pojavi med nosečnostjo; to zmanjša dostopnost presnovnih substratov za rast plodu.
English: If you forget to take Glidipion
Slovenian: Če ste pozabili vzeti zdravilo Glidipion
English: In the 3.5 year PROactive study, 44/870 (5.1%) of pioglitazone-treated female patients experienced fractures compared to 23/905 (2.5%) of female patients treated with comparator.
Slovenian: V 3,5-letni študiji PROactive je imelo zlom 44 od 870 (5,1 %) žensk, zdravljenih s pioglitazonom, in 23 od 905 (2,5 %) žensk, zdravljenih s primerjalnim zdravilom.
English: Repeated dosing does not result in accumulation of the compound or metabolites.
Slovenian: Večkratno odmerjanje ne povzroči kopičenja pioglitazona ali njegovih presnovkov.
English: 3 In controlled clinical trials the incidence of reports of heart failure with pioglitazone treatment was the same as in placebo, metformin and sulphonylurea treatment groups, but was increased when used in combination therapy with insulin.
Slovenian: V kontroliranih kliničnih preskušanjih je bila incidenca srčnega popuščanja med zdravljenjem s pioglitazonom enaka kot med prejemniki placeba, metformina in sulfonilsečnine, večja pa je bila med uporabo v kombiniranem zdravljenju z insulinom.
English: - if you have had diabetic ketoacidosis (a complication of diabetes causing rapid weight loss,
Slovenian: - če imate diabetično ketoacidozo (zaplet sladkorne bolezni, ki povzroči hitro izgubljanje telesne mase, slabost v želodcu ali bruhanje).
English: If you stop taking Glidipion
Slovenian: Če ste prenehali jemati zdravilo Glidipion
English: Not all the pack sizes may be marketed.
Slovenian: Na trgu ni vseh navedenih pakiranj.
English: Patients should be advised to promptly seek the attention of their physician if macroscopic haematuria or other symptoms such as dysuria or urinary urgency develop during treatment.
Slovenian: Bolnikom je treba naročiti, da morajo v primeru makroskopske hematurije ali drugih simptomov (npr. dizurije ali nuje za uriniranje), ki se pojavijo med zdravljenjem, takoj obiskati zdravnika.
English: Each tablet contains 113.31 mg of lactose monohydrate (see section 4.4).
Slovenian: Ena tableta vsebuje 113,31 mg laktoza monohidrata (glejte poglavje 4.4).
English: What you need to know before you take Glidipion Do not take Glidipion
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo glidipion
English: The tablets are supplied in aluminium blister packs of 14, 28, 30, 50, 56, 84, 90, 98 and 100 tablets.
Slovenian: Tablete so na voljo v aluminijskih pretisnih omotih s 14, 28, 30, 50, 56, 84, 90, 98 ali 100 tabletami.
English: Similar changes were seen in metformin (haemoglobin 3-4% and haematocrit 3.6-4.1% relative reductions) and to a lesser extent sulphonylurea and insulin (haemoglobin 1-2% and haematocrit 1-3.2% relative reductions) treated patients in comparative controlled trials with pioglitazone.
Slovenian: Podobne spremembe so opažali v primerjalnih kontroliranih preskušanjih s pioglitazonom pri bolnikih, zdravljenih z metforminom (relativno znižanje hemoglobina za 3-4 % in hematokrita za 3,6-4,1 %), in v manjši meri pri bolnikih, zdravljenih s sulfonilsečnino in insulinom (relativno znižanje hemoglobina za 1-2 % in hematokrita za 1- 3,2 %).
English: In vitro studies have shown no inhibition of any subtype of cytochrome P450.
Slovenian: Študije in vitro niso pokazale zavrtja nobenega podtipa citokroma P450.
English: Pioglitazone should be used with caution during concomitant administration of cytochrome P450 2C8 inhibitors (e.g. gemfibrozil) or inducers (e.g. rifampicin).
Slovenian: Pioglitazon je treba uporabljati previdno med sočasnim zdravljenjem z zaviralci citokroma P450 2C8 (npr. z gemfibrozilom) ali njegovimi induktorji (npr. z rifampicinom).
English: In vitro studies have shown no evidence that pioglitazone inhibits any subtype of cytochrome P450.
Slovenian: Študije in vitro niso pokazale, da bi pioglitazon zaviral katerokoli podvrsto citokroma P450.