FrancophonIA/ELRC3.0 huggingface dataset:
English: Thrombolytics: the safety of the concomitant administration of clopidogrel, fibrin or non-fibrin specific thrombolytic agents and heparins was assessed in patients with acute myocardial infarction.
Danish: Trombolytika: Sikkerheden ved samtidig administration af clopidogrel, fibrin eller nonfibrinspecifikke trombolytiske midler og hepariner blev bedømt hos patienter med akut myokardieinfarkt.
English: SSRIs: since SSRIs affect platelet activation and increase the risk of bleeding, the concomitant administration of SSRIs with clopidogrel should be undertaken with caution.
Danish: SSRI'er: Da SSRI'er påvirker trombocytaktiveringen og øger risikoen for blødning, skal samtidig administration af SSRI'er og clopidogrel ske med forsigtighed.
English: Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, carbamazepine, and efavirenz.
Danish: LægemidlerPotente og moderate CYP2C19-hæmmere inkluderer for eksempel omeprazol og esomeprazol, fluvoxamin, fluoxetin, moclobemid, voriconazol, fluconazol, ticlopidin, carbamazepin og efavirenz.
English: Clopidogrel significantly reduced the relative risk of death from any cause by 7% (p=0.029), and the relative risk of the combination of re-infarction, stroke or death by 9% (p=0.002), representing an absolute reduction of 0.5% and 0.9%, respectively.
Danish: Clopidogrel reducerede signifikant den relative dødsrisiko uanset årsag med 7 % (p = 0,029) og den relative risiko for kombinationen af re-infarkt, slagtilfælde eller død med 9 % (p=0,002), hvilket repræsenterer en absolut reduktion på henholdsvis 0,5 % og 0,9 %.
English: The safety and efficacy of clopidogrel have been evaluated in 5 double-blind studies involving over 88,000 patients: the CAPRIE study, a comparison of clopidogrel to ASA, and the CURE, CLARITY, COMMIT and ACTIVE-A studies comparing clopidogrel to placebo, both medicinal products given in combination with ASA and other standard therapy.
Danish: Sikkerheden og effekten af clopidrogrel er blevet evalueret i 5 dobbeltblindede studier, der omfattede mere end 88.000 patienter i CAPRIE-studiet, hvor clopidogrel sammenlignes med ASA, og CURE-, CLARITY-, COMMIT- og ACTIVE-A-studierne, hvor clopidogrel sammenlignes med placebo, og hvor begge lægemidler gives i kombination med ASA eller anden standardterapi.
English: The recommended dose for ASA was 75 to 100 mg/day.
Danish: Den anbefalede ASA-dosis var 75 til 100 mg / dag.
English: Patients on aspirin and a more potent P2Y12 blocker and without adverse event at one month were assigned to switch to fixed-dose aspirin plus clopidogrel (de-escalated dual antiplatelet therapy (DAPT)) or continuation of their drug regimen (unchanged DAPT).
Danish: Patienter behandlet med aspirin og en mere potent P2Y12-hæmmer, og uden bivirkning ved en måned blev skiftet til fast dosis aspirin plus clopidogrel (de-eskaleret dobbelt trombocythæmmende behandling (DAPT)), eller fortsatte deres medicin regime (uændret DAPT).
English: In CHARISMA and one cohort study (Simon), an increased event rate was observed only in poor metabolisers when compared to extensive metabolisers.
Danish: I CHARISMA og et kohortestudie (Simon) sås kun en øget hyppighed af hændelser hos poor metabolisers i sammenligning med extensive metabolisers.
English: However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 2 ‘Warnings and precautions'').
Danish: Hvis du er bekymret over din blødning, skal du omgående kontakte din læge (se afsnit 2 ”Advarsler og forsigtighedsregler”).
English: - You have an irregular heartbeat, a condition called ‘atrial fibrillation', and you cannot take medicines known as ‘oral anticoagulants' (vitamin K antagonists) which prevent new clots from forming and prevent existing clots from growing.
Danish: - Du har uregelmæssig hjerterytme (en sygdom kaldet ”atrieflimren”) og ikke må tage medicin kendt som orale antikoagulantia (vitamin K-antagonister), der kan forebygge dannelsen af nye blodpropper og forhindre eksisterende blodpropper i at vokse.
English: If you are breast-feeding or planning to breast-feed, talk to your doctor before taking this medicine.
Danish: Hvis du ammer eller planlægger at amme, skal du tale med din læge, før du tager denne medicin.
English: This is linked to the way your medicine works as it prevents the ability of blood clots to form.
Danish: Dette skyldes medicinens virkemåde, da den forhindrer at blodet i at størkne.
English: New cardiovascular events (primary endpoint) were prevented, with relative risk reductions of 22% (CI: 8.6, 33.4), 32% (CI: 12.8, 46.4), 4% (CI: -26.9, 26.7), 6% (CI: -33.5, 34.3) and 14% (CI: -31.6, 44.2), during the 0-1, 1-3, 3-6, 6-9 and 9-12 month study intervals, respectively.
Danish: blev forebygget med relative risikoreduktioner på 22 % (CI: 8,6, 33,4) 32 % (CI: 12,8, 46,4), 4 % (CI: -26,9, 26,7), 6 % (CI: -33,5, 34,3) og 14 % (CI: -31,6, 44,2), i løbet af studiets intervaller på henholdsvis 0-1, 1-3, 3-6, 6-9 og 9-12 måneder.
English: Detailed information is available on the European Medicines Agency website: http://www.ema.europa.eu
Danish: på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu/.
English: and acetylsalicylic acid for this condition.
Danish: og acetylsalicylsyre.
English: Furthermore, the pharmacodynamic activity of clopidogrel was not significantly influenced by the co-administration of phenobarbital or oestrogen.
Danish: Herudover blev clopidogrels farmakodynamiske aktivitet ikke påvirket signifikant af samtidig administration af phenobarbital eller østrogen.
English: Patients randomized in the ACTIVE program were those presenting with documented AF, i.e., either permanent AF or at least 2 episodes of intermittent AF in the past 6 months, and had at least one of the following risk factors: age 75 years or age 55 to 74 years and either diabetes mellitus requiring drug therapy, or documented previous MI or documented coronary artery disease; treated for systemic hypertension; prior stroke, transient ischaemic attack (TIA), or non-CNS systemic embolus; left ventricular dysfunction with left ventricular ejection fraction <45%; or documented peripheral vascular disease.
Danish: Patienter randomiseret i ACTIVE-programmet var dem, der blev præsenteret med dokumenteret AF, dvs. enten permanent AF eller mindst 2 episoder med intermitterende AF inden for de seneste 6 måneder, og som havde mindst én af følgende risikofaktorer: alder ≥ 75 år eller alder 55 til 74 år og enten behandlingskrævende diabetes mellitus eller dokumenteret tidligere MI eller dokumenteret koronararteriesygdom; behandlingskrævende systemisk hypertension; apopleksi, transitorisk cerebral iskæmi (TCI), eller non-CNS systemisk emboli i anamnesen; venstre ventrikel dysfunktion med venstre ventrikel uddrivningsfraktion <45% eller dokumenteret perifer vaskulær sygdom.
English: This benefit was consistent across all prespecified subgroups including patients' age and gender, infarct location, and type of fibrinolytic or heparin used.
Danish: Denne fordel var konsekvent blandt alle præspecificerede undergrupper, hvor der både blev taget hensyn til patientens alder, køn, hvor infarktet var lokaliseret og den type fibrinolytika eller hepariner der blev anvendt til behandling.
English: A significantly lower exposure to clopidogrel active metabolite and reduced platelet inhibition has been demonstrated in HIV-infected patients treated with ritonavir- or cobicistat-boosted anti-retroviral therapies (ART).
Danish: En signifikant lavere eksponering for clopidogrels aktive metabolit og reduceret trombocythæmning er påvist hos hiv-smittede patienter i behandling med ritonavir- eller cobicistat-boostet antiretroviral terapi (ART).
English: • You should also tell your doctor immediately if you develop a medical condition (also known as Thrombotic Thrombocytopenic Purpura or TTP) that includes fever and bruising under the skin that may appear as red pinpoint dots, with or without unexplained extreme tiredness, confusion, yellowing of the skin or eyes (jaundice) (see section 4 ‘Possible side effects').
Danish: • skal du også fortælle det til din læge med det samme, hvis du udvikler en medicinsk tilstand (trombocytisk trombocytopenisk purpura eller TTP)der giver feber og blå mærker under huden, der kan fremstå som små røde prikker, med eller uden uforklarlig ekstrem træthed, forvirring, gulning af huden eller øjnene (gulsot) (se afsnit 4 ”Bivirkninger”).
English: The efficacy of clopidogrel was observed independently of the dose of ASA (75-325 mg once daily).
Danish: Clopidogrels virkning blev observeret uden relation til doseringen af ASA (75-325 mg en gang dagligt).
English: Thienopyridines may cause mild to severe allergic reactions such as rash, angioedema, or haematological cross-reactions such as thrombocytopaenia and neutropaenia.
Danish: Thienopyridiner kan forårsage lette til alvorlige allergiske reaktioner såsom udslæt og angioødem eller hæmatologiske krydsreaktioner såsom trombocytopeni og neutropeni.
English: The cumulative incidence of all bleeding events (BARC class 1 to 5) was 9% (114 events) in the guided de-escalation group versus 11% (137 events) in the control group (p=0.14).
Danish: Den kumulative forekomst af alle blødningshændelser (BARC klasse 1 til 5) var 9% (114 hændelser) i den guidede de-eskaleringsgruppe versus 11% (137 hændelser) i kontrolgruppen (p = 0,14).
English: This benefit was mostly driven by the statistically significant reduction in the incidence of MI [287 (4.6%) in the clopidogrel-treated group and 363 (5.8%) in the placebo-treated group].
Danish: Fordelen må hovedsageligt tilskrives den statistisk signifikante reduktion i forekomsten af myokardieinfarkt [287 (4,6 %) i clopidogrelgruppen og 363 (5,8 %) i placebogruppen].
English: The major exclusion criteria for patients were documented peptic ulcer disease within the previous 6 months; prior intracerebral hemorrhage; significant thrombocytopenia (platelet count < 50 x 10
Danish: Udelukkelseskriteriet var hovedsageligt patienter med følgende sygdomme; dokumenteret peptisk ulcus inden for de sidste 6 måneder, intracerebral blødning i anamnesen, signifikant trombocytopeni (trombocyttal <50 x 10
English: The clinical benefit provided by the more potent P2Y12 inhibitors, ticagrelor and prasugrel, in their pivotal studies is related to a significant reduction in recurrent ischaemic events (including acute and subacute stent thrombosis (ST), myocardial infarction (MI), and urgent revascularization).
Danish: Den kliniske fordel af de mere potente P2Y12-hæmmere, ticagrelor og prasugrel, er i deres pivotale studier relateret til en signifikant reduktion af tilbagevendende iskæmiske hændelser (inklusive akut og subakut stenttrombose (ST), myokardieinfarkt (MI) og akut revaskularisering).
English: - The other ingredients are microcrystalline cellulose, colloidal anhydrous silica, crospovidone (type A), macrogol 6000 and hydrogenated castor oil in the tablet core and polyvinyl alcohol, titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172), talc and macrogol 3000 in the film-coating.
Danish: - Øvrige indholdsstoffer: mikrokrystallinsk cellulose, vandfri kolloid silica, crospovidon (type A), macrogol 6000, hydrogeneret ricinusolie i tabletkernen og polyvinylalkohol, titandioxid (E171), rødt jernoxid (E172), gul jernoxid (E172), talcum og macrogol 3000 i tabletfilmen.
English: In vitro and in vivo, clopidogrel is metabolised according to two main metabolic pathways: one mediated by esterases and leading to hydrolysis into its inactive carboxylic acid derivative (85% of circulating metabolites), and one mediated by multiple cytochromes P450.
Danish: In vitro og in vivo bliver clopidogrel metaboliseret via to primære veje: En esterasemedieret, hvorved det hydrolyseres til dets inaktive carboxylsyrederivat (85% af de cirkulerende metabolitter), og en medieret af flere cytochrom P450isoenzymer.
English: The co-primary endpoints were death from any cause and the first occurrence of re-infarction, stroke or death.
Danish: Det primære endepunkt var død uanset årsag og den første forekomst af re-infarkt, apopleksi eller død.
English: • For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.
Danish: • Mere end 12 timer efter planlagt administration: patienten skal tage næste dosis som planlagt og ikke tage dobbelt dosis.
English: Clopidogrel significantly reduced the incidence of new ischaemic events (combined end point of myocardial infarction, ischaemic stroke and vascular death) when compared to ASA.
Danish: Clopidogrel reducerede signifikant forekomsten af nye iskæmiske tilfælde (kombineret endepunkt, der omfattede myokardieinfarkt, iskæmisk apopleksi og vaskulær død) ved sammenligning med ASA.
English: No substantial differences in active metabolite exposure and mean inhibition of platelet aggregation (IPA) were observed between ultrarapid, extensive and intermediate metabolisers.
Danish: Det blev ikke observeret nogen betydende forskelle i eksponering for den aktive metabolit og gennemsnitlig hæmning af trombocytfunktionen (IPA) mellem ultrahurtige, extensive eller intermediate metabolisers.
English: in combination with acetylsalicylic acid, a substance present in many medicines used to relieve pain and lower fever.
Danish: i kombination med acetylsalicylsyre, som er et stof, der indgår i mange typer medicin til smertelindring og febersænkning.
English: Although the clinical relevance of these findings is uncertain, there have been spontaneous reports of HIV-infected patients treated with boosted ART, who have experienced reocclusive events after de-obstruction or have suffered thrombotic events under a clopidogrel loading treatment schedule.
Danish: Den kliniske relevans af disse fund er usikker, men der har været spontane indberetninger fra hiv-smittede patienter i behandling med boostet antiretroviral terapi, som har oplevet re-okklusive hændelser efter de-obstruktion eller oplevet trombotiske hændelser under støddosisbehandling med clopidogrel.
English: In addition, IPA was 32% (24 hours) and 61% (Day 5), which were greater than in the poor metabolisers receiving the 300 mg/75 mg regimen, and were similar to the other CYP2C19 metaboliser groups receiving the 300 mg/75 mg regimen.
Danish: Desuden var IPA på 32 % (24 timer) og 61 % (dag 5), hvilket var større end hos poor metabolisers, der fik 300 mg/75 mg-regimet, og svarede til IPA ved 300 mg/75 mg regimet hos de andre grupper af CYP2C19-metabolisers.
English: Although the administration of clopidogrel 75 mg/day did not modify the pharmacokinetics of S-warfarin or International Normalised Ratio (INR) in patients receiving long-term warfarin therapy, coadministration of clopidogrel with warfarin increases the risk of bleeding because of independent effects on hemostasis.
Danish: Selvom administration af 75 mg clopidogrel daglig ikke ændrede S-warfarins farmakokinetik eller International Normalised Ratio (INR) hos patienter i langtidsbehandling med warfarin, øgede samtidig administration af clopidogrel og warfarin blødningsrisikoen på grund af uafhængig effekt på hæmostasen.
English: Warnings and precautions If any of the situations mentioned below apply to you, you should tell your doctor before taking Clopidogrel Krka d.d.
Danish: Advarsler og forsigtighedsregler Hvis nogen af følgende situationer gælder for dig, skal du oplyse det til din læge, før du tager Clopidogrel Krka d.d.
English: A total of 99.7% of patients received fibrinolytics (fibrin specific: 68.7%, non- fibrin specific: 31.1%), 89.5% heparin, 78.7% beta blockers, 54.7% ACE inhibitors and 63% statins.
Danish: En total på 99,7 % af patienterne fik fibrinolytika (fibrinspecifik: 68,7 %, non-fibrin specifik: 31,1 %), 89,5 % fik heparin, 78,7 % betablokkere, 54,7 % ACE-hæmmere og 63 % statiner.
English: Blister of OPA/Alu/PVC-Alu containing 7, 14, 28, 30, 50, 56, 84, 90 and 100 film-coated tablets in the box.
Danish: Blisterkort af OPA/Al/PVC-Al i æsker med 7, 14, 28, 30, 50, 56, 84, 90 og 100 filmovertrukne tabletter.
English: The CLARITY trial included 3,491 patients presenting within 12 hours of the onset of a ST elevation MI and planned for thrombolytic therapy.
Danish: CLARITY-studiet inkluderede 3.491 patienter, der var til rådighed inden for 12 timer efter at et MI med elevation af ST-segmentet var indtrådt, og som det var planlagt at give en trombolytisk behandling.
English: In TRITON-TIMI 38 and 3 of the cohort studies (Collet, Sibbing, Giusti) the combined group of patients with either intermediate or poor metaboliser status had a higher rate of cardiovascular events (death, myocardial infarction, and stroke) or stent thrombosis compared to extensive metabolisers.
Danish: I TRITON-TIMI 38 og 3 af kohortestudierne (Collet, Sibbing, Giusti) havde den kombinerede gruppe af patienter med status som enten intermediate eller poor metabolisers en højere hyppighed af kardiovaskulære hændelser (død, myokardieinfarkt og apopleksi) eller stenttrombose sammenlignet med extensive metabolisers.
English: Clopidogrel was found to have no effect on the fertility of male and female rats and was not teratogenic in either rats or rabbits.
Danish: Der blev ikke fundet fertilitetseffekt hos rotter af begge køn, og clopidogrel udviste ingen teratogen virkning hos rotter eller kaniner.
English: Always take this medicine exactly as your doctor or pharmacist has told you.
Danish: Tag altid lægemidletnøjagtigt efter lægens eller apotekspersonalets anvisning.
English: By preventing this clumping, antiplatelet medicinal products reduce the chances of blood clots forming (a process called thrombosis).
Danish: Ved at forhindre denne sammenklumpning nedsætter et blodpropopløsende præparat,, risikoen for, at der dannes blodpropper (en proces, der kaldes trombose).
English: Tests are available to determine a patient's CYP2C19 genotype.
Danish: Der er test tilgængelige til at bestemme en patients CYP2C19genotype.
English: 75 mg film-coated tablets
Danish: 75 mg filmovertrukne tabletter
English: Thrombocytopenia, leucopenia, eosinophilia
Danish: Trombocytopeni, leukopeni, eosinofili
English: In view of the lack of data, clopidogrel cannot be recommended during the first 7 days after acute ischaemic stroke.
Danish: På grund af manglende data kan clopidogrel ikke anbefales til akut iskæmisk apopleksi (inden for 7 dage efter iskæmisk stroke).
English: Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på pakningen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Germany
Danish: KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenien TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Tyskland
English: For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
Danish: Hvis du ønsker have yderligere oplysninger om Clopidogrel Krka d.d., skal du henvende dig til den lokale repræsentant for indehaveren af markedsføringstilladelsen:
English: An occasional use of acetylsalicylic acid (no more than 1000 mg in any 24 hour period), should generally not cause a problem, but prolonged use in other circumstances should be discussed with your doctor.
Danish: Lejlighedsvis brug af acetylsalicylsyre (højst 1000 mg i løbet af et døgn) skulle generelt ikke give problemer.
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 2 or section
Danish: • Overfølsomhed over for det aktive stof eller over for et eller flere af hjælpestofferne anført i pkt.
English: This statistically significant difference was mainly driven by fewer bleeding events, with no difference reported in ischaemic endpoints (p=0.36), while BARC ≥2 bleeding occurred less frequently in the de-escalated DAPT group (4.0%) versus 14.9% in the unchanged DAPT group (p<0.01).
Danish: Denne statistisk signifikante forskel skyldtes hovedsagelig færre blødninger, uden forskel rapporteret i iskæmiske endepunkter (p = 0,36), mens BARC ≥2 blødning forekom mindre hyppigt i den de-eskalerede DAPT-gruppe (4,0%) versus 14,9% i den uændrede DAPT gruppe (p <0,01).
English: In patients with acute ST-segment elevation MI, safety and efficacy of clopidogrel have been evaluated in 2 randomised, placebo-controlled, double-blind studies, CLARITY and COMMIT.
Danish: Hos patienter med akut myokardieinfarkt (MI) med elevation af ST-segmentet blev sikkerhed og virkning af clopidrogrel vurderet i 2 randomiserede, placebo-kontrollerede, dobbeltblindede studier kaldet CLARITY og COMMIT.
English: There was no observed effect on the rate of rehospitalisation for unstable angina.
Danish: Der sås ingen virkning på forekomsten af genindlæggelse som følge af ustabil angina pectoris.
English: The guided de-escalation did not result in an increased combined risk of ischemic events (2.5% in the deescalation group vs 3.2% in the control group; p non-inferiority=0.0115), nor in the key secondary endpoint of BARC bleeding ≥2 ((5%) in the de-escalation group versus 6% in the control group (p=0.23)).
Danish: Den guidede de-eskalering resulterede ikke i en øget kombineret risiko for iskæmiske hændelser (2,5% i de-eskaleringsgruppen mod 3,2% i kontrolgruppen, p non-inferioritet = 0,0115), heller ikke i det centrale sekundære endepunkt for BARC ≥2 blødning ((5%) i de-eskaleringsgruppen versus 6% i kontrolgruppen (p = 0,23)).
English: Exposure of clopidogrel and average platelet inhibition can be decreased with concomitant use of ritonavir.
Danish: Eksponeringen for clopidogrel og den gennemsnitlige trombocythæmning kan blive nedsat ved samtidig anvendelse af ritonavir.
English: However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 4 ‘Possible side effects').
Danish: Hvis du er bekymret over din blødning, skal du omgående kontakte din læge (se afsnit 4 ”Bivirkninger”).
English: A crossover study in 40 healthy subjects, 10 each in the four CYP2C19 metaboliser groups (ultrarapid, extensive, intermediate and poor), evaluated pharmacokinetic and antiplatelet responses using 300 mg followed by 75 mg/day and 600 mg followed by 150 mg/day, each for a total of 5 days (steady state).
Danish: Et cross-over studie med 40 raske forsøgspersoner, 10 i hver af de fire CYP2C19-metaboliser-grupper (ultrahurtig, extensive, intermediate eller poor), evaluerede farmakokinetisk og trombocythæmmende respons ved dosering af 300 mg efterfulgt af 75 mg/dag og 600 mg efterfulgt af 150 mg/dag, hver i alt 5 dage (steady state).
English: After the 300 mg/75 mg dose regimen, antiplatelet responses were decreased in the poor metabolisers with mean IPA (5 μM ADP) of 24% (24 hours) and 37% (Day 5) as compared to IPA of 39% (24 hours) and 58% (Day 5) in the extensive metabolisers and 37% (24 hours) and 60% (Day 5) in the intermediate metabolisers.
Danish: Ved 300 mg/75 mg dosisregimet var det trombocythæmmende respons nedsat hos poor metabolisers med en gennemsnitlig IPA (5 µM ADP) på 24 % (24 timer) og 37 % (dag 5), sammenlignet med IPA på 39 % (24 timer) og 58 % (dag 5) for extensive metabolisers og 37 % (24 timer) og 60 % (dag 5) hos intermediate metabolisers.
English: Gastrointestinal and retroperitoneal haemorrhage with fatal outcome, pancreatitis, colitis (including ulcerative or lymphocytic colitis), stomatitis
Danish: Gastrointestinal og retroperitoneal blødning med dødeligt udfald, bugspytkirtelbetændelse, colitis (inklusive ulcerøsa eller lymfocytisk colitis), stomatitis
English: The Cmax of the active metabolite is twice as high following a single 300-mg clopidogrel loading dose as it is after four days of 75-mg maintenance dose.
Danish: Cmax for den aktive metabolit er dobbelt så høj efter en enkelt initial mætningsdosis på 300 mg clopidogrel, som den er efter fire dage med 75 mg vedligeholdelsesdosis.