FrancophonIA/ELRC3.0 huggingface dataset:
English: The safety profile of voriconazole in adults is based on an integrated safety database of more than 2,000 subjects (including 1,603 adult patients in therapeutic trials) and an additional 270 adults in prophylaxis trials.
Slovenian: Varnostni profil vorikonazola pri odraslih temelji na integrirani varnostni podatkovni bazi več kot 2.000 preskušancev (vključno s 1.603 odraslimi bolniki v terapevtskih preskušanjih) in dodatnih 270 odraslih v študijah profilakse.
English: Includes nuchal rigidity and tetany.
Slovenian: Vključuje rigidnost tilnika in tetanijo.
English: The instructions should be followed for reconstitution, dilution and administration of each kit.
Slovenian: Sledite navodilom za rekonstitucijo, redčenje in aplikacijo vsakega kompleta.
English: VFEND must not be infused into the same line or cannula concomitantly with other intravenous products.
Slovenian: Zdravila VFEND se ne sme infundirati v isto linijo ali kanilo sočasno z drugimi intravenskimi pripravki.
English: A satisfactory global response (complete or partial resolution of all attributable symptoms, signs, radiographic/bronchoscopic abnormalities present at baseline) was seen in 53% of voriconazole-treated patients compared to 31% of patients treated with comparator.
Slovenian: Zadovoljiv globalni odziv (popolno ali delno izginotje vseh izhodiščno prisotnih pripisljivih simptomov, znakov, rentgenoloških/bronhoskopskih nenormalnosti) so ugotovili pri 53 % bolnikov, zdravljenih z vorikonazolom, in pri 31 % bolnikov, zdravljenih s primerjalnim zdravilom.
English: If you or your child are taking VFEND for prevention of fungal infections, your doctor may stop giving VFEND if you or your child develop treatment related side effects.
Slovenian: Če vi ali vaš otrok jemljete zdravilo VFEND za preprečevanje glivičnih okužb, vam bo zdravnik morda prenehal dajati zdravilo VFEND, če se pri vas ali vašemu otroku pojavijo neželeni učinki, povezani z zdravljenjem.
English: Voriconazole is rapidly and almost completely absorbed following oral administration, with maximum plasma concentrations (Cmax) achieved 1-2 hours after dosing.
Slovenian: Vorikonazol se po peroralni uporabi hitro in skoraj popolnoma absorbira in doseže največjo koncentracijo v plazmi (Cmax) 1 do 2 uri po zaužitju.
English: When cleared, proceed as directed.
Slovenian: Ko težavo odpravite, nadaljujte po navodilih.
English: If the medicine is to be given to a child, make sure the child is sitting, or is held, upright before giving the medicine.
Slovenian: Če zdravilo dajete otroku, se prepričajte, da otrok sedi ali ga držite v pokončnem položaju, preden mu date zdravilo.
English: If a dose of VFEND has been forgotten
Slovenian: Če je bil odmerek zdravila VFEND pozabljen
English: The species most frequently involved in causing human infections include C. albicans, C. parapsilosis, C. tropicalis, C. glabrata and C. krusei, all of which usually exhibit minimal inhibitory concentration (MICs) of less than 1 mg/L for voriconazole.
Slovenian: Vrste, ki so najpogosteje vpletene pri povzročanju okužb pri ljudeh, so C. albicans, C. parapsilosis, C. tropicalis, C. glabrata in C. krusei, pri čemer pri vseh naštetih minimalna inhibitorna koncentracija (MIK) za vorikonazol običajno znaša manj kot 1 mg/L.
English: Pfizer Europe MA EEIG (as MA Holder logo)
Slovenian: Pfizer Europe MA EEIG (kot logo imetnika dovoljenja za promet z zdravilom)
English: Powder: store at in a refrigerator before constitution.
Slovenian: Prašek: pred pripravo shranjujte v hladilniku.
English: If the liver function tests become markedly elevated, VFEND should be discontinued, unless the medical judgment of the risk-benefit of the treatment for the patient justifies continued use.
Slovenian: Če se vrednosti testov jetrne funkcije izrazito zvečajo, je treba zdravljenje z zdravilom VFEND prekiniti, razen če medicinska ocena koristi in tveganj zdravljenja za bolnika upravičuje nadaljnjo uporabo.
English: Instructions for Use - please be guided by the pictograms to understand how to use this product.
Slovenian: Navodila za uporabo - za navodila glede uporabe tega zdravila prosimo sledite slikovnim navodilom (piktogramom).
English: Do not take VFEND: If you are allergic to voriconazole or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Če ste alergični na vorikonazol ali katerokoli sestavino tega zdravila (navedeno v poglavju 6).
English: In the same study, no significant differences in Cmax and AUCτ were observed between healthy elderly males and healthy elderly females (≥65 years).
Slovenian: V isti študiji niso ugotovili pomembnih razlik Cmax in AUCτ med zdravimi starejšimi moški in zdravimi starejšimi ženskami (≥ 65 let).
English: Pharmacokinetic/pharmacodynamic Relationship
Slovenian: Odnos med farmakokinetiko/farmakodinamiko
English: In fluconazole-resistant non-albicans species, a successful outcome was seen in 3/3 C. krusei (complete responses) and 6/8 C. glabrata (5 complete, 1 partial response) infections.
Slovenian: Pri ne-albicans vrstah, odpornih na flukonazol, so uspešen odziv ugotovili pri 3/3 okužbah s C. krusei (popolni odzivi) in 6/8 okužbah s C. glabrata (5 popolnih, 1 delni odziv).
English: There is limited data on the safety of VFEND in patients with abnormal liver function tests (aspartate transaminase [AST], alanine transaminase [ALT], alkaline phosphatase [ALP], or total bilirubin >5 times the upper limit of normal).
Slovenian: Na voljo so omejeni podatki o varnosti zdravila VFEND pri bolnikih z nenormalnimi testi jetrne funkcije (aspartat-aminotransferaza [AST], alanin-aminotransferaza [ALT], alkalna fosfataza [ALP] ali celotni bilirubin > 5-kratna zgornja meja normalne vrednosti).
English: Powder for solution for infusion and powder for oral suspension: Fareva Amboise
Slovenian: Prašek za raztopino za infundiranje in prašek za peroralno suspenzijo Fareva Amboise
English: Gently mix the contents of the infusion bag.
Slovenian: Nežno premešajte vsebino infuzijske vrečke.
English: Constituted suspension: Do not store above 30°C; do not refrigerate or freeze.
Slovenian: Pripravljena suspenzija: Shranjujte pri temperaturi do 30 ˚C, ne shranjujte v hladilniku ali zamrzujte.
English: If you take more VFEND than you should
Slovenian: Če ste vzeli večji odmerek zdravila VFEND, kot bi smeli
English: The survival rate at Day 180 was 80.0% (32/40) and at 1 year was 70.0% (28/40).
Slovenian: Po 180 dneh je bila stopnja preživetja 80,0 % (32/40), po 1 letu pa
English: Following constitution, the volume of the suspension is 75 ml, providing a usable volume of 70 ml.
Slovenian: Po pripravi je volumen suspenzije 75 ml oz. uporabni volumen 70 ml.
English: Do not take a double dose to make up for the forgotten dose.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: Patients receiving VFEND must be carefully monitored for hepatic toxicity.
Slovenian: Bolnike, ki dobivajo zdravilo VFEND, je treba skrbno nadzorovati glede hepatotoksičnosti.
English: Patients less than 40 kg*
Slovenian: bolniki s telesno maso manj kot 40 kg*
English: If large bubbles can be seen, slowly push the plunger back into the syringe.
Slovenian: Če opazite velike mehurčke, počasi porinite bat brizge nazaj v brizgo.
English: VFEND must not be diluted with 4.2% Sodium Bicarbonate Infusion.
Slovenian: Zdravila VFEND se ne sme redčiti z infuzijo 4,2 % natrijevega bikarbonata.
English: Success at day 100
Slovenian: Uspešnost na 100. dan
English: If the required volume of VFEND concentrate as described in the table below requires the use of multiple vials in order to provide the appropriate dose for a given body weight, then multiple infusion kits should be used.
Slovenian: Če zahtevani volumen VFEND koncentrata za zagotovitev primernega odmerka za dano telesno maso zahteva uporabo več vial, kot je opisano v spodnji preglednici, je treba uporabiti več infuzijskih kompletov.
English: This represents a heterogeneous population, containing patients with haematological malignancy, HIV-infected patients with oesophageal candidiasis and refractory fungal infections, non-neutropenic patients with candidaemia or aspergillosis and healthy volunteers.
Slovenian: Gre za heterogeno populacijo, ki zajema bolnike s hematološkimi malignomi, s HIV okužene bolnike s kandidiazo požiralnika in refraktarnimi glivičnimi okužbami, nenevtropenične bolnike s kandidemijo ali aspergilozo ter zdrave prostovoljce.
English: In clinical trials, 705 patients received voriconazole therapy for greater than 12 weeks, with 164 patients receiving voriconazole for over 6 months.
Slovenian: V kliničnih preskušanjih je 705 bolnikov dobivalo vorikonazol več kot 12 tednov, 164 pa več kot 6 mesecev.
English: Survived to day 180
Slovenian: Preživetje do 180. dneva
English: Includes immune thrombocytopenic purpura.
Slovenian: Vključuje imunsko trombocitopenično purpuro.
English: VFEND must not be used during pregnancy unless the benefit to the mother clearly outweighs the potential risk to the foetus.
Slovenian: Zdravila VFEND se med nosečnostjo ne sme uporabljati, razen če koristi za mater upravičujejo potencialno nevarnost za plod.
English: • For dilution, gently invert the vial, vial adapter and syringe assembly and withdraw the required volume of the reconstituted concentrate into the syringe (see table below).
Slovenian: • Za redčenje nežno obrnite vialo in nastavek za vialo z nameščeno brizgo ter odvzemite zahtevani volumen rekonstituiranega koncentrata v brizgo (glejte preglednico spodaj).
English: The major metabolite of voriconazole is the N-oxide, which accounts for 72% of the circulating radiolabelled metabolites in plasma.
Slovenian: Glavni presnovek vorikonazola je N-oksid; na njegov račun gre 72 % radioaktivno označenih presnovkov, ki krožijo v plazmi.
English: Photosensitivity reactions such as ephelides, lentigo and actinic keratosis have been reported, especially during long-term therapy (see section 4.4).
Slovenian: Opisane so bile fotosenzitivnostne reakcije kot so efelide, lentigo ter aktinična keratoza, zlasti med dolgotrajnim zdravljenjem (glejte poglavje 4.4).
English: A comparison of the paediatric and adult population pharmacokinetic data indicated that the predicted total exposure (AUC) in children following administration of a 9 mg/kg IV loading dose was comparable to that in adults following a 6 mg/kg IV loading dose.
Slovenian: Primerjava podatkov populacijske farmakokinetike pediatrične in odrasle populacije kaže, da je bila pričakovana celokupna izpostavljenost (AUC) pri otrocih po uporabi 9 mg/kg intravenskega polnilnega odmerka primerljiva s tisto pri odraslih po uporabi 6 mg/kg intravenskega polnilnega odmerka.
English: If you are already being treated with rifabutin your blood counts and side effects to rifabutin will need to be monitored.
Slovenian: Če se že zdravite z rifabutinom, bo treba nadzirati vašo krvno sliko in neželene učinke rifabutina.
English: The adaptor is provided so that you can fill the oral syringe with medicine from the bottle.
Slovenian: Nastavek je priložen zato, da lahko napolnite peroralno brizgo z zdravilom iz plastenke.
English: Dose reduction of benzodiazepines should be considered.
Slovenian: Razmisliti je treba o zmanjšanju odmerka benzodiazepinov.
English: (Loading Dose)
Slovenian: (polnilni odmerek)
English: Add 2 measuring cups of water, providing a total volume of 46 ml.
Slovenian: Dodajte 2 merici vode oz. skupni volumen 46 ml.
English: In a secondary analysis, which utilised DRC assessments at the latest evaluable time point (EOT, or 2, 6, or 12 weeks after EOT) voriconazole and the regimen of amphotericin B followed by fluconazole had successful response rates of 65% and 71%, respectively.
Slovenian: V sekundarni analizi, ki je uporabljala oceno OPP na najpoznejši ocenljivi časovni točki (konec terapije ali 2, 6 ali 12 tednov po koncu terapije), je bil delež uspešnega odziva z vorikonazolom 65 %, s shemo amfotericin B/flukonazol pa 71 %.
English: 6c Prime the IV line according to the manufacturer's guidelines.
Slovenian: 6c Napolnite infuzijski sistem skladno s smernicami proizvajalca.
English: The shelf life of the constituted suspension is 14 days.
Slovenian: Rok uporabnosti pripravljene suspenzije je 14 dni.
English: VFEND, is a broad-spectrum, triazole antifungal agent and is indicated in adults and children aged 2 years and above as follows:
Slovenian: Zdravilo VFEND je širokospektralen triazolski antimikotik, indiciran pri odraslih in otrocih, starih 2 leti ali več, za:
English: Treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei).
Slovenian: - zdravljenje hudih, invazivnih, proti flukonazolu odpornih okužb s Candido (vključno s C. krusei)
English: Serum creatinine levels should be closely monitored in these patients and, if increases occur, consideration should be given to changing to oral voriconazole therapy (see section 5.2).
Slovenian: Pri teh bolnikih je treba skrbno nadzirati raven kreatinina v serumu; če se zviša, je treba razmisliti o prehodu na peroralno zdravljenje z vorikonazolom (glejte poglavje 5.2).
English: Please tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including those that are obtained without a prescription.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katerokoli drugo zdravilo, tudi če ste ga dobili brez recepta.
English: Nine subjects in the voriconazole group and 5 in the amphotericin B followed by fluconazole group also had mycologically proven infection in deep tissue.
Slovenian: Devet preskušancev v skupini z vorikonazolom in 5 v skupini z amfotericinom B/flukonazolom je imelo tudi mikološko dokazano okužbo v globokem tkivu.
English: Instructions for reconstitution and use:
Slovenian: Navodila za rekonstitucijo in uporabo:
English: VFEND is supplied as a white to off-white powder for oral suspension providing a white to off-white, orange flavoured suspension when constituted with water.
Slovenian: VFEND je na voljo v obliki belega do belkastega praška za peroralno suspenzijo, iz katerega dobimo po pripravi z vodo belo do belkasto suspenzijo z okusom pomaranče.
English: Patients with severe hepatic impairment must be carefully monitored for drug toxicity (see section 4.8).
Slovenian: Bolnike s hudo jetrno okvaro je treba natančno nadzirati glede toksičnih učinkov zdravila (glejte poglavje 4.8).
English: In the pre- and post-natal development study in rats at exposures lower than those obtained in humans with therapeutic doses, voriconazole prolonged the duration of gestation and labour and produced dystocia with consequent maternal mortality and reduced perinatal survival of pups.
Slovenian: V študijah pre- in postnatalnega razvoja pri podganah je vorikonazol ob izpostavljenosti, manjši kot je pri ljudeh dosežena s terapevtskimi odmerki, podaljšal gestacijo in porod ter povzročil distocijo s posledično maternalno umrljivostjo in zmanjšanim perinatalnim preživetjem mladičev.
English: P-Value
Slovenian: Vrednost p
English: Other medicines and VFEND
Slovenian: Druga zdravila in zdravilo VFEND
English: Voriconazole was administered intravenously with a loading dose of 6 mg/kg every 12 hours for the first 24 hours followed by a maintenance dose of 4 mg/kg every 12 hours for a minimum of 7 days.
Slovenian: Vorikonazol so dajali intravensko s polnilnim odmerkom 6 mg/kg vsakih 12 ur prvih 24 ur, nato je sledil vzdrževalni odmerek 4 mg/kg vsakih 12 ur najmanj 7 dni.
English: Contraindicated (see section
Slovenian: Kontraindicirano (glejte poglavje
English: Strains with MIC values above the Susceptible (S) breakpoint are rare, or not yet reported.
Slovenian: 1 Sevi z vrednostmi MIK nad mejno vrednostjo Občutljivo (S) so redki, oziroma o njih še niso poročali.
English: After administration of a radiolabelled dose of voriconazole, approximately 80% of the radioactivity is recovered in the urine after multiple intravenous dosing and 83% in the urine after multiple oral dosing.
Slovenian: Po uporabi radioaktivno označenega odmerka vorikonazola se po večkratnem intravenskem odmerjanju v urinu pojavi približno 80 % radioaktivnosti, po večkratnem peroralnem odmerjanju pa 83 %.
English: If any side effects occur, most are likely to be minor and temporary.
Slovenian: Če se kakršnikoli neželeni učinki sploh pojavijo, so običajno blagi in prehodni.
English: In an independent published study, Voriconazole AUC0-  59%
Slovenian: v neodvisni, objavljeni študiji, vorikonazol AUC0-  59 %
English: Tell your doctor if you are taking the following medicine, as treatment with VFEND at the same time should be avoided if possible:
Slovenian: Obvestite zdravnika, če jemljete naslednje zdravilo, kajti sočasnemu dajanju tega zdravila z zdravilom VFEND se je treba, če je to mogoče, izogniti:
English: • Warfarin and other anticoagulants (e.g., phenprocoumon, acenocoumarol; used to slow down clotting of the blood)
Slovenian: • varfarin ali druge antikoagulante (npr. fenprokumon, acenokumarol; uporabljajo se za upočasnitev strjevanja krvi)
English: Compared to efavirenz 600 mg QD, Efavirenz Cmax ↔ Efavirenz AUC  17%
Slovenian: v primerjavi s 600 mg efavirenza QD, efavirenz Cmax ↔ efavirenz AUC  17 %
English: In vitro data showed a slight increase of resistance of C. glabrata to voriconazole.
Slovenian: Podatki in vitro so pokazali rahlo zvečanje odpornosti C. glabrata na vorikonazol.
English: Voriconazole is eliminated via hepatic metabolism with less than 2% of the dose excreted unchanged in the urine.
Slovenian: Izločanje Vorikonazol se izloča z jetrno presnovo; manj kot 2 % odmerka se nespremenjenega izloči v urinu.
English: No subject experienced an interval exceeding the potentially clinically-relevant threshold of 500 msec.
Slovenian: Pri nobenem izmed preskušancev interval ni presegel potencialno klinično pomembnega praga 500 milisekund.
English: Voriconazole Cmax and AUC ↔
Slovenian: vorikonazol Cmax and AUC ↔
English: Put the tip of the oral syringe into the mouth.
Slovenian: Vstavite vrh peroralne brizge v usta.
English: There have been reports of squamous cell carcinoma of the skin in patients treated with VFEND for long periods of time; the mechanism has not been established (see section 4.4).
Slovenian: Pri bolnikih, ki so se dlje časa zdravili z zdravilom VFEND, so poročali o ploščatoceličnemu karcinomu kože; mehanizem ni dokazan (glejte poglavje 4.4).
English: Includes hypoxic-ischaemic encephalopathy and metabolic encephalopathy.
Slovenian: Vključuje hipoksično-ishemično encefalopatijo in presnovno encefalopatijo.
English: VFEND suspension is constituted if it is in a liquid form.
Slovenian: Zdravilo VFEND suspenzija je pripravljeno, ko je v tekoči obliki.
English: R-methadone (active) Cmax  31% R-methadone (active) AUC  47% S-methadone Cmax  65% S-methadone AUC  103%
Slovenian: R-metadon (aktivni) Cmax  31 % R-metadon (aktivni) AUC  47 % S-metadon Cmax  65 % S-metadon AUC  103 %
English: If this occurs, turn the vial upright and pull the piston up the syringe barrel.
Slovenian: Če se to zgodi, obrnite vialo v pokončni položaj in povlecite bat navzgor.
English: The reconstituted solution can be diluted with:
Slovenian: Rekonstituirano raztopino je mogoče redčiti z:
English: EUCAST has not determined non-species related breakpoints for voriconazole.
Slovenian: EUCAST ni določil mejnih vrednosti za vorikonazol, ki niso povezane z vrsto.
English: Visual impairments may be associated with higher plasma concentrations and/or doses.
Slovenian: Okvare vida so lahko povezane z večjimi koncentracijami v plazmi in/ali večjimi odmerki.
English: Add 2 measuring cups (measure cup included in the carton) of water (total of 46 ml) to the bottle.
Slovenian: Dodajte 2 merici (merica je priložena v škatli) vode (skupno 46 ml) v plastenko.
English: • The other ingredients are lactose monohydrate, pregelatinised starch, croscarmellose sodium, povidone and magnesium stearate which make up the tablet core and hypromellose, titanium dioxide (E171), lactose monohydrate and glycerol triacetate which make up the film-coat.
Slovenian: • Druge sestavine zdravila so: laktoza monohidrat, predgelirani škrob, premreženi natrijev karmelozat, povidon in magnezijev stearat, ki sestavljajo jedro tablete, in hipromeloza, titanov dioksid (E171), laktoza monohidrat in triacetin, ki sestavljajo filmsko oblogo.
English: It has been shown that taking all doses at the appropriate times may greatly increase the effectiveness of your medicine.
Slovenian: Dokazano je, da lahko redno jemanje zdravila, brez izpuščanja odmerkov, ter jemanje ob pravem času zelo poveča njegovo učinkovitost.
English: While being treated with VFEND:
Slovenian: Med zdravljenjem z zdravilom VFEND:
English: Use the oral syringe provided in the pack to measure the correct dose.
Slovenian: Uporabite peroralno brizgo, priloženo v ovojnini, s katero odmerite pravilen odmerek.
English: Once constituted, VFEND oral suspension should only be administered using the oral syringe supplied with each pack.
Slovenian: Že pripravljeno VFEND peroralno suspenzijo lahko jemljemo le z uporabo peroralne brizge, ki je priložena vsakemu pakiranju.
English: Some medicines, when taken at the same time as VFEND, may affect the way VFEND works or VFEND may affect the way they work.
Slovenian: Nekatera zdravila, uporabljena sočasno z zdravilom VFEND, lahko vplivajo na njegovo delovanje, ali pa lahko zdravilo VFEND vpliva na delovanje teh zdravil.
English: Developed proven or probable IFI while on study drug * Primary endpoint of the study ** Difference in proportions, 95% CI and p-valuesobtained after adjustment for randomization
Slovenian: Razvoj dokazane ali verjetne IGO med jemanjem preiskovanega zdravila * Primarni opazovani dogodek v študiji ** Razlike v deležih, 95 % IZ in vrednosti p, pridobljeni po prilagoditvi za randomizacijo
English: Fill the measuring cup to the top of the marked line then pour the water into the bottle.
Slovenian: Merico napolnite do vrha označene črte in zlijte vodo v plastenko.
English: • This will provide an extractable volume of 20 ml of clear concentrate containing 10 mg/ml of voriconazole.
Slovenian: • Na ta način boste dobili 20 ml ekstraktabilnega volumna bistrega koncentrata, ki vsebuje 10 mg/ml vorikonazola.
English: Remove the cap. Press the bottle adaptor into the neck of the bottle (as shown on figure below).
Slovenian: Vstavite nastavek za plastenko v vrat plastenke (kot kaže slika spodaj).
English: A 4-hour haemodialysis session does not remove a sufficient amount of voriconazole to warrant dose adjustment.
Slovenian: Štiriurna hemodializa ne odstrani toliko vorikonazola, da bi bilo treba prilagoditi odmerek.
English: • Oxycodone and other long-acting opiates such as hydrocodone (used for moderate to severe pain)
Slovenian: • oksikodon in druge dolgodelujoče opiate, kot na primer hidrokodon (uporablja se pri zmernih do hudih bolečinah)
English: Continue taking VFEND until your doctor tells you to stop.
Slovenian: Zdravilo VFEND jemljite, dokler vam zdravnik ne naroči, da z jemanjem prenehajte.
English: Fluconazole (CYP2C9, CYP2C19 and CYP3A4 inhibitor) Coadministration of oral voriconazole and oral fluconazole resulted in a significant increase in Cmax and AUCτ of voriconazole in healthy subjects.
Slovenian: Flukonazol (zaviralec CYP2C9, CYP2C19 in CYP3A4) Sočasno peroralno jemanje vorikonazola in flukonazola je imelo za posledico pomembno povečanje Cmax in AUCτ vorikonazola pri zdravih preskušancih.
English: These visual impairments were transient and fully reversible, with the majority spontaneously resolving within 60 minutes and no clinically significant long-term visual effects were observed.
Slovenian: Okvare vida so bile prehodne in popolnoma reverzibilne; večina jih je spontano minila v 60 minutah in niso opazili nobenih klinično pomembnih dolgotrajnih učinkov na vid. Obstajali so dokazi o njihovem zmanjševanju s ponavljajočimi odmerki vorikonazola.