FrancophonIA/ELRC3.0 huggingface dataset:
English: • Flu-like illness
Slovenian: • gripi podobni simptomi
English: The concomitant use of other central nervous system depressants, (including opioids, sedatives, hypnotics, general anaesthetics, phenothiazines, tranquilizers, sedating antihistamines, and alcoholic beverages) and skeletal muscle relaxants, may produce additive depressant effects; hypoventilation, hypotension, profound sedation, coma or death may occur.
Slovenian: sedativi, hipnotiki, splošnimi anestetiki, fenotiazini, trankvilizanti, sedativnimi antihistaminiki in alhokolnimi pijačami) in relaksanti skeletnih mišic ima lahko dodatne zaviralne učinke; pojavijo se lahko hipoventilacija, hipotenzija, globoka sedacija, koma ali smrt.
English: How to dispose of used patches or patches you no longer use A used or unused patch accidentally sticking to another person, especially a child, may be fatal.
Slovenian: Uporabljen ali neuporabljen obliž, ki se po nesreči prilepi na drugo osebo, predvsem na otroka, je lahko smrtno nevaren.
English: 3b oxycodone oral parenteral oxymorphone rectal parenteral
Slovenian: 3b oksikodon peroralna parenteralna oksimorfon rektalna parenteralna
English: PHARMACEUTICAL FORM AND CONTENTS Transdermal patch [To be completed nationally]
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA transdermalni obliž [izpolni država članica]
English: DUROGESIC and alcohol Do not drink alcohol while using DUROGESIC unless you have talked to your doctor first.
Slovenian: Med zdravljenjem z zdravilom DUROGESIC ne pijte alkohola, razen če ste se pred tem pogovorili s svojim zdravnikom.
English: Excretion occurs primarily, as metabolites, with less than 10% of the dose excreted as unchanged active substance.
Slovenian: Sekrecija poteka predvsem v obliki presnovkov, manj kot 10% zdravilne učinkovine se izloči nespremenjene.
English: Caution should be exercised when treating patients with myasthenia gravis.
Slovenian: Pri zdravljenju bolnikov z miastenijo gravis je potrebna previdnost.
English: Fold the sachet at the notch, then carefully tear the sachet material.
Slovenian: Vrečico prepognemo po zarezi in nato previdno pretrgamo.
English: DUROGESIC doses should be individualised based upon the status of the patient and should be assessed at regular intervals after application.
Slovenian: Odmerek zdravila DUROGESIC je treba prilagoditi vsakemu bolniku posebej, glede na njegovo stanje, in po namestitvi obliža v rednih intervalih ocenjevati njegovo ustreznost.
English: • DUROGESIC may make you unusually drowsy, and make your breathing more slow or shallow.
Slovenian: • Zdravilo DUROGESIC lahko povzroči neobičajno zaspanost ter počasnejše ali plitvejše dihanje.
English: The safety of DUROGESIC was evaluated in 289 paediatric subjects (<18 years) who participated in 3 clinical studies for the management of chronic or continuous pain of malignant or non-malignant origin.
Slovenian: Varnost in učinkovitost zdravila DUROGESIC so ocenili pri 289 pediatričnih preiskovancih (< 18 let), ki so sodelovali v 3 kliničnih študijah obvladovanja kronične ali neprestane bolečine rakavega ali nerakavega izvora.
English: • Some medicines used to treat cancer of the blood (such as idelalisib).
Slovenian: • Nekatera zdravila za zdravljenje krvnega raka (kot je idelalizib).
English: To guard against accidental ingestion by children, use caution when choosing the application site for DUROGESIC (see sections 4.2 and 6.6) and monitor adhesion of the patch closely.
Slovenian: Da bi pri otrocih preprečili, da bi po nesreči zaužili zdravilo, je potrebna posebna previdnost pri izbiri mesta namestitve transdermalnega obliža DUROGESIC (glejte poglavji 4.2 in 6.6) ter redno spremljanje prilepljenosti obliža.
English: DUROGESIC contains a medicine called fentanyl.
Slovenian: Zdravilo DUROGESIC vsebuje zdravilno učinkovino fentanil.
English: • Feeling sleepy (somnolence)
Slovenian: • zaspanost (somnolenca)
English: Fentanyl is rapidly distributed to various tissues and organs, as indicated by the large volume of distribution (3 to 10 L/kg after intravenous dosing in patients).
Slovenian: Fentanil se hitro porazdeli med različna tkiva in organe, kar kaže velik volumen porazdelitve (3 do
English: DUROGESIC may be worn continuously for 72 hours.
Slovenian: Zdravilo DUROGESIC se lahko neprekinjeno nosi 72 ur.
English: The serum fentanyl concentrations attained are proportional to the DUROGESIC patch size.
Slovenian: Linearnost/nelinearnost Serumske koncentracije fentanila so proporcionalne velikosti transdermalnega obliža DUROGESIC.
English: 1 Conversion to DUROGESIC dosages greater than 25 mcg/h is the same for paediatric patients as it is for adult patients
Slovenian: 1 Pretvorba v odgovarjajoči odmerek transdermalnih obližev DUROGESIC pri odmerkih, večjih od 25 mikrogramov/h, je za pediatrične in odrasle bolnike enaka (glejte preglednico 2).
English: 20b ketobemidone oral parenteral levorphanol oral parenteral
Slovenian: 20b ketobemidon peroralna parenteralna levorfanol peroralna parenteralna
English: Data from intravenous studies with fentanyl suggest that elderly patients may have reduced clearance, a prolonged half-life, and they may be more sensitive to the drug than younger patients.
Slovenian: Podatki iz študij z intravensko injiciranim fentanilom kažejo, da imajo starejši bolniki lahko zmanjšan očistek, podaljšan razpolovni čas in so lahko bolj občutljivi na zdravilo v primerjavi z mlajšimi bolniki.
English: The dose of DUROGESIC may need to be increased or a switch to another analgesic active substance may be needed.
Slovenian: Morda bo treba prilagoditi odmerek zdravila DUROGESIC ali preiti na zdravljenje z drugim analgetikom.
English: • The patches are waterproof
Slovenian: • Obliži so odporni na vodo.
English: Within 72 hours of IV fentanyl administration, approximately 75% of the dose is excreted into the urine and approximately 9% of the dose into the faeces.
Slovenian: injiciranju fentanila, se približno 75 % odmerka fentanila izloči z urinom in približno 9 % z blatom.
English: • Medicines used to treat an irregular heart beat (such as amiodarone, diltiazem, or verapamil).
Slovenian: • Zdravila za zdravljenje nepravilnega srčnega utripa (kot so amiodaron, diltiazem ali verapamil).
English: If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before using DUROGESIC.
Slovenian: Če karkoli od naštetega velja za vas (ali niste prepričani), se pred uporabo zdravila DUROGESIC
English: DUROGESIC with antidepressants
Slovenian: Zdravilo DUROGESIC skupaj z antidepresivi
English: There is a high inter-subject variability in fentanyl pharmacokinetics, in the relationships between fentanyl concentrations, therapeutic and adverse effects, and in opioid tolerance.
Slovenian: V farmakokinetiki fentanila, v razmerju med koncentracijami fentanila ter terapevtskimi in neželenimi učinki in v toleranci na opioide so velike razlike med preiskovanci.
English: • Some medicines used to treat epilepsy (such as carbamazepine, phenobarbital, or phenytoin).
Slovenian: • Nekatera zdravilaza zdravljenje epilepsije (kot so karbamazepin, fenobarbital ali fenitoin).
English: The resultant prolongation in gastrointestinal transit time may be responsible for the constipating effect of fentanyl.
Slovenian: Posledično se gastrointestinalni čas prehoda podaljša, kar je lahko vzrok za zaprtje zaradi fentanila.
English: Patients should be advised on measures to prevent constipation and prophylactic laxative use should be considered.
Slovenian: Bolnikom je treba svetovati, kako preprečiti zaprtje; premisliti pa je potrebno tudi o preventivni uporabi odvajal.
English: If you are not sure, talk to your doctor or pharmacist before using DUROGESIC.
Slovenian: Če niste prepričani, se pred uporabo zdravila DUROGESIC posvetujte z zdravnikom ali farmacevtom.
English: Do not sunbathe, have long hot baths or saunas or use hot whirlpool spa baths.
Slovenian: Ne izpostavljajte se sončenju, dolgotrajnim vročim kopelim ali savnam in ne uporabljajte vročih termalnih masažnih bazenov.
English: Therefore after a dose increase, patients should wear the higher dose patch through two 72-hour applications before any further increase in dose level is made.
Slovenian: Zato mora bolnik pred morebitnim naslednjim povečanjem odmerka obliž uporabljati dve 72-urni obdobji.
English: There have been reports of patches accidentally sticking to a family member while in close physical contact or sharing the same bed as the person wearing the patch.
Slovenian: Znano je nekaj primerov, ko se je obliž ob tesnem stiku po nesreči prilepil na družinskega člana pri souporabi postelje.
English: Other medicines and DUROGESIC
Slovenian: Druga zdravila in zdravilo DUROGESIC
English: It is recommended that DUROGESIC is used in patients who have demonstrated opioid tolerance (see section 4.2).
Slovenian: Zdravilo DUROGESIC je priporočljivo uporabljati pri bolnikih, ki so že razvili toleranco na opioide (glejte poglavje 4.2).
English: In a study conducted with DUROGESIC, healthy elderly subjects had fentanyl pharmacokinetics which did not differ significantly from healthy young subjects although peak serum concentrations tended to be lower and mean half-life values were prolonged to approximately 34 hours.
Slovenian: Študija zdravila DUROGESIC je pokazala, da v farmakokinetiki fentanila pri zdravih starejših in zdravih mlajših preiskovancih ni statistično značilnih razlik, kljub temu, da so največje serumske koncentracije fentanila pri starejših manjše in povprečni razpolovni čas podaljšan na približno 34 ur.
English: Follow the advice above and keep the person who was wearing the patch moving and talking as much as possible.
Slovenian: Bolnik, ki je uporabljal obliž naj se ves čas premika in čimveč govori.
English: • Medicines for relaxing your muscles (such as cyclobenzaprine or diazepam).
Slovenian: • Zdravila za sproščanje mišic (kot sta cikobenzaprin ali diazepam).
English: Starting dosages of 25 mcg/h and higher were used by the remaining 179 subjects, 174 (97.2%) of whom had been on opioid doses of at least 45 mg of oral morphine equivalents per day.
Slovenian: Ostalih 179 preiskovancev je prejemalo začetne odmerke 25 mikrogramov/h ali večje, 174 (97,2 %) jih je predhodno prejemalo odmerek opioida, ki ustreza vsaj 45 mg peroralnega morfina na dan. Izmed ostalih 5 preiskovancev z začetnim odmerkom vsaj 25
English: All patients should be advised to avoid exposing the DUROGESIC application site to direct external heat sources such as heating pads, electric blankets, heated water beds, heat or tanning lamps, sunbathing, hot water bottles, prolonged hot baths, saunas and hot whirlpool spa baths.
Slovenian: Bolnikom je treba naročiti, naj mesta aplikacije zdravila DUROGESIC ne izpostavljajo direktnim zunanjim virom toplote (grelne blazine, električne odeje, ogrevane vodne postelje, toplotne luči ali luči za umetno porjavitev, sončenje, termoforji, dolgotrajne vroče kopeli, savna, vroče masažne kopeli).
English: (frequency cannot be estimated from the available data.)
Slovenian: To so lahko znaki hude alergijske reakcije (pogostnosti ni mogoče oceniti iz razpoložljivih podatkov.
English: 1 In clinical studies these ranges of daily oral morphine doses were used as a basis for conversion to DUROGESIC.
Slovenian: 1 V kliničnih študijah so uporabili zgoraj navedene dnevne peroralne odmerke morfina kot osnovo za pretvorbo v odgovarjajoči odmerek zdravila DUROGESIC.
English: Make certain that the edges of the patch are adhering properly.
Slovenian: Preverimo, da so tudi robovi obliža dobro prilepljeni.
English: • Medicines used to treat fungal infection (such as itraconazole, ketoconazole, fluconazole, or voriconazole).
Slovenian: • Zdravila za zdravljenje glivičnih okužb (kot so itrakonazol, ketokonazol, flukonazol ali vorikonazol).
English: Elderly patients should be observed carefully and the dose should be individualised based upon the status of the patient (see sections 4.4 and 5.2).
Slovenian: Starejše bolnike je treba skrbno spremljati in odmerek glede na status prilagoditi vsakemu bolniku posebej (glejte poglavji 4.4 in 5.2).
English: In opioid-naïve elderly patients, treatment should only be considered if the benefits outweigh the risks.
Slovenian: O zdravljenju starejših bolnikov, ki opioidov še niso uporabljali, se sme razmisliti le, kadar prednosti zdravljenja odtehtajo tveganja.
English: Fentanyl, a high clearance active substance, is rapidly and extensively metabolised mainly by CYP3A4.
Slovenian: Fentanil je zdravilo z visokim očistkom, ki se hitro in obsežno presnavlja zlasti preko encima CYP3A4.
English: Breastfeeding should therefore be discontinued during treatment with DUROGESIC and for at least 72 hours after removal of the patch.
Slovenian: Med zdravljenjem z zdravilom Durogesic in vsaj še 72 ur po odstranitvi obliža je dojenje potrebno prekiniti.
English: If concomitant use of DUROGESIC with a CYP3A4 inhibitor cannot be avoided, close monitoring for signs or symptoms of increased or prolonged therapeutic effects and adverse effects of fentanyl (in particular respiratory depression) is warranted, and the DUROGESIC dosage must be reduced or interrupted as deemed necessary (see section 4.5).
Slovenian: CYP3A4 ne moremo izogniti, je treba biti posebej pozoren na znake ali simptome povečanega ali podaljšanega terapevtskega učinka in pojava neželenih učinkov fentanila (predvsem na depresijo dihanja), odmerek zdravila DUROGESIC pa po potrebi zmanjšati ali pa zdravljenje prekiniti (glejte poglavje 4.5)
English: 2 In clinical studies these ranges of daily oral morphine doses were used as a basis for conversion to DUROGESIC.
Slovenian: 2 V kliničnih študijah so uporabili zgoraj navedene dnevne peroralne odmerke morfina kot osnovo za pretvorbo v odgovarjajoči odmerek transdermalnih obližev DUROGESIC.
English: Fentanyl is a high clearance active substance and is rapidly and extensively metabolised primarily by CYP3A4 in the liver.
Slovenian: Fentanil ima velik očistek, se hitro in obsežno presnavlja v jetrih, predvsem s CYP3A4.
English: It may take 20 hours or more for the fentanyl serum concentrations to decrease 50%.
Slovenian: Za zmanjšanje serumske koncentracije fentanila za 50% je potrebno 20 ur ali več.
English: Patches should be inspected prior to use.
Slovenian: • Obliž je treba pred uporabo pregledati glede morebitne poškodbe.
English: DUROGESIC may have more severe adverse effects in patients with chronic obstructive or other pulmonary disease.
Slovenian: Kronična bolezen pljuč Neželeni učinki zdravila DUROGESIC pri bolnikih s kronično obstruktivno pljučno boleznijo ali drugimi boleznimi pljuč so lahko resnejši.
English: PHARMACEUTICAL FORM Transdermal patch.
Slovenian: FARMACEVTSKA OBLIKA transdermalni obliž
English: • Feeling agitated or disoriented
Slovenian: • občutek razdraženosti ali disorientiranosti
English: Then they should be safely discarded by putting them back into the original sachet and stored out of sight and reach of other people, especially children, until safely disposed.
Slovenian: Nato jih morate dati v njihovo originalno vrečico in jih hraniti nedosegljivo drugim ljudem, predvsem otrokom, dokler jih ne boste na varen način zavrgli.
English: Cases of serious respiratory depression after coadministration of CYP3A4 inhibitors with transdermal fentanyl have been reported, including a fatal case after coadministration with a moderate CYP3A4 inhibitor.
Slovenian: Po sočasni uporabi zaviralcev CYP3A4 in transdermalnega fentanila so poročali so o primerih resne depresije dihanja, vključno s smrtnim primerom po sočasni uporabi z zmernimi zaviralci CYP3A4.
English: nausea (35.7%), vomiting (23.2%), constipation (23.1%), somnolence (15.0%), dizziness (13.1%), and headache (11.8%).
Slovenian: Na osnovi združenih podatkov o varnosti iz teh kliničnih študij so bili najpogosteje poročani neželeni učinki (tj. pojavnost ≥ 10 %): navzea (35,7 %), bruhanje (23,2 %), zaprtje (23,1 %), somnolenca (15,0%), omotica (13,1 %) in glavobol (11,8 %).
English: • Keep used patches out of sight and reach of children - even used patches contain some medicine which may harm children and may even be fatal
Slovenian: • Tudi uporabljeni obliži vsebujejo nekaj zdravila, ki lahko škoduje otrokom, in lahko povzročijo tudi smrt.
English: In opioid-naïve patients with renal or hepatic impairment, treatment should only be considered if the benefits outweigh the risks.
Slovenian: O zdravljenju bolnikov z okvaro ledvic ali jeter, ki opioidov še niso uporabljali, se sme razmisliti le, kadar prednosti zdravljenja odtehtajo tveganja.
English: The concomitant use of DUROGESIC with cytochrome P450 3A4 (CYP3A4) inhibitors may result in an increase in fentanyl plasma concentrations, which could increase or prolong both the therapeutic and adverse effects, and may cause serious respiratory depression.
Slovenian: Sočasna uporaba zdravila DUROGESIC in zaviralcev citokroma P450 3A4 (CYP3A4) lahko povzroči večje plazemske koncentracije fentanila, kar lahko poveča ali podaljša terapevtski učinek fentanila in neželene učinke ter povzroči resno depresijo dihanja.
English: Patients with renal or hepatic impairment should be observed carefully and the dose should be individualised based upon the status of the patient (see sections 4.4 and 5.2).
Slovenian: Bolnike z okvaro ledvic ali jeter je treba skrbno spremljati, odmerek pa glede na status prilagoditi vsakemu bolniku posebej (glejte poglavi 4.4 in 5.2).
English: Agitation, Disorientation, Euphoric mood
Slovenian: depresija, anksioznost, stanje zmedenosti, halucinacije agitacija, dezorientiranost, evforično razpoloženje
English: The interval between IV antagonist doses should be carefully chosen because of the possibility of re-narcotization after the patch is removed; repeated administration or a continuous infusion of naloxone may be necessary.
Slovenian: Presledek med odmerki intravenskega antagonista je treba skrbno izbrati, ker obstaja možnost renarkotizacije po odstranitvi obliža.
English: 6b fentanyl oral parenteral hydromorphone oral parenteral
Slovenian: 6b fentanil peroralna parenteralna hidromorfon peroralna parenteralna
English: How to use DUROGESIC
Slovenian: Kako uporabljati zdravilo DUROGESIC
English: A lag time of 12 to 24 hours after application of the first patch and after a dose increase must be taken into account.
Slovenian: Po aplikaciji prvega obliža in po zvečanju odmerka je treba upoštevati 12- do 24-urni čas do nastopa polnega učinka.
English: After coadministration of weak, moderate or strong CYP3A4 inhibitors with short term intravenous fentanyl administration, decreases in fentanyl clearance were generally ≤25%,
Slovenian: Po sočasnem dajanju šibkih, zmernih ali močnih zaviralcev CYP3A4 in kratkotrajne uporabe fentanila se je očistek fentanila na splošno zmanjšal za ≤ 25%, z ritonavirjem (močen zaviralec CYP3A4) pa se je očistek fentanila v povprečju zmanjšal za 67%.
English: Additional restrictions apply to opioid-naïve patients with renal impairment (see section 4.2).
Slovenian: Dodatne omejitve je treba upoštevati pri bolnikih z okvaro ledvic, ki še niso prejemali opioidov (glejte poglavje 4.2).
English: Step 5: Wash • Always wash your hands after you have handled the patch using clean water only
Slovenian: • Roke si vedno umijte s čisto vodo.
English: In case the patch sticks to the skin of another person, take the patch off right away and get medical attention.
Slovenian: V takem primeru je potrebno obliž takoj odstraniti s kože in poiskati medicinsko pomoč.
English: • Medicines for helping you sleep (such as temazepam, zaleplon, or zolpidem).
Slovenian: • Zdravila za zdravljenje težav sspanjem (temazepam, zaleplon ali zolpidem).
English: Musculoskeletal and connective tissue disorders
Slovenian: Bolezni mišično skeletnega sistema in vezivnega tkiva mišični krči trzanje mišic
English: • Excessive sweating
Slovenian: • čezmerno potenje
English: • Talk to your doctor before you stop using these patches
Slovenian: Če želite prenehati uporabljati obliže • Pogovorite se s svjim zdravnikom, preden prenehate uporabljati te obliže.
English: Patients may require periodic supplemental doses of a short acting analgesic for “breakthrough” pain.
Slovenian: Lahko se zgodi, da bodo bolniki za lajšanje prebijajoče bolečine potrebovali dodatni kratkodelujoči analgetik.
English: There have been very rare reports of newborn infants experiencing neonatal withdrawal syndrome when mothers chronically used DUROGESIC during pregnancy (see section 4.6).
Slovenian: Če so matere med nosečnostjo dolgo časa jemale zdravilo DUROGESIC, so pri novorojencih zelo redko poročali o odtegnitvenem sindromu (glejte poglavje 4.6).
English: DUROGESIC Dosage (mcg/h)
Slovenian: Odmerek zdravila DUROGESIC (mikrogrami/h)
English: Table 2: Recommended starting dosage of DUROGESIC based upon daily oral morphine dose (for patients who have a need for opioid rotation or for clinically less stable patients: conversion ratio of oral morphine to transdermal fentanyl is approximately equal to 150:1) 1
Slovenian: Preglednica 2: Priporočeni začetni odmerek zdravila DUROGESIC, glede na dnevni peroralni odmerek morfina (za bolnike, pri katerih je potrebno menjavanje opioidov ali za klinično manj stabilne bolnike: pretvorbeno razmerje peroralnega morfina v transdermalni fentanil je približno 150:1) 1
English: • Press this sticky part of the patch onto the skin
Slovenian: • To lepljivo stran obliža pritisnite na kožo.
English: In the circumstance in which commencing with oral opioids is not considered possible and DUROGESIC is considered to be the only appropriate treatment option for opioid-naïve patients, only the lowest starting dose (ie, 12 mcg/h) should be considered.
Slovenian: Kadar ocenimo, da pri bolnikih, ki še niso prejemali opioidov, uvedba peroralnih opioidov ni možna in je za zdravljenje primerno le zdravilo DUROGESIC, ga je treba uvesti z najmanjšim odmerkom (to je 12 mikrogramov/h).
English: If you do, you may increase the amount of medicine you get from the patch.
Slovenian: To lahko zveča količino zdravila, ki se sprosti iz obliža.
English: The concomitant use of transdermal fentanyl with CYP3A4 inducers may result in a decrease in fentanyl plasma concentrations and a decreased therapeutic effect.
Slovenian: Sočasna uporaba transdermalnega fentanila in induktorjev CYP3A4 lahko povzroči zmanjšanje plazemske koncentracije fentanila in terapevtskega učinka.
English: As a result of continued absorption of fentanyl from the skin depot after removal of the patch, the half-life of fentanyl after transdermal administration is about 2- to 3-fold longer than intravenous administration.
Slovenian: Zaradi kontinuirane absorbcije fentanila skozi depo v koži je po odstranitvi obliža razpolovni čas fentanila (transdermalna uporaba) okrog 2
English: Among the remaining 5 subjects with a starting dosage of at least 25 mcg/h whose prior opioid doses were <45 mg of oral morphine equivalents per day, 1 (0.6%) had previously been receiving <30 mg of oral morphine equivalents per day and 4 (2.2%) had been receiving 30 to 44 mg of oral morphine equivalents per day (see section 4.8).
Slovenian: mikrogramov/h, ki so predhodno prejemali odmerek opioida, ki ustreza < 45 mg peroralnega morfina na dan, je 1 (0,6%) predhodno prejemal odmerek opioida, ki ustreza < 30 mg peroralnega morfina na dan, 4 (2,2%) pa so prejemali odmerek opioida, ki ustreza 30 do 40 mg peroralnega morfina na dan (glejte poglavje 4.8).
English: Tell your doctor if you notice any of these effects.
Slovenian: Če opazite katerega koli izmed teh učinkov, se posvetujte z zdravnikom.
English: Pharmacodynamic-related interactions
Slovenian: Interakcije, povezane s farmakokinetiko
English: Table 5: Adverse reactions in adult and paediatric patients System/organ class
Slovenian: Neželeni učinki pri odraslih in pediatričnih bolnikih
English: b Based on single-dose studies in which an IM dose of each active substance listed was compared with morphine to establish the relative potency.
Slovenian: b Na osnovi študij z enkratnim odmerkom, pri katerih so primerjali i.m.