FrancophonIA/ELRC3.0 huggingface dataset:
English: Liver metabolism is a minor route of elimination.
Croatian: Metabolizam u jetri je put kojim se olopatadin ne eliminira u znatnijoj mjeri.
English: • After cap is removed, if the tamper evident snap collar is loose, remove before using the product.
Croatian: • Nakon skidanja poklopca, ukoliko je zaštitni obruč za evidenciju otvaranja klimav, uklonite ga prije primjene lijeka.
English: In patients with patent nasolacrimal ducts, topical ocular administration of Opatanol was suggested to reduce the nasal signs and symptoms that frequently accompany seasonal allergic conjunctivitis.
Croatian: Pretpostavlja se da topikalna okularna primjena Opatanola u bolesnika s funkcionirajućim nazolakrimalnim kanalićima ublažava nazalne znakove i simptome koji često prate sezonski alergijski konjunktivitis.
English: Shortness of breath, increased allergic symptoms, facial swelling, drowsiness, generalized weakness, nausea, vomiting, sinus infection, skin redness and itching.
Croatian: Nedostatak zraka, pojačani alergijski simptomi, oticanje lica, pospanost, opća slabost, mučnina, povraćanje, infekcija sinusa, crvenilo kože i svrbež.
English: System Organ Classification
Croatian: Klasifikacija organskih sustava Učestalost
English: • Take the bottle and twist off the cap.
Croatian: • Uzmite bočicu i otvorite poklopac.
English: Following a 10 mg oral dose in patients undergoing haemodialysis (with no urinary output), plasma olopatadine concentrations were significantly lower on the haemodialysis day than on the non-haemodialysis day suggesting olopatadine can be removed by haemodialysis.
Croatian: U bolesnika na hemodijalizi (bez stvaranja urina), koncentracija olapatadina u plazmi, nakon peroralne doze od 10 mg, bila je znatno niža na dan kad je obavljena hemodijaliza, negoli u dane kad je nije bilo, što upućuje na to da se olapatadin može ukloniti hemodijalizom.
English: Opatanol is an antiallergic/antihistaminic agent and, although administered topically, is absorbed systemically.
Croatian: Opatanol je antialergik/antihistaminik i apsorbira se sustavno i pri topikalnoj primjeni.
English: Blurred, reduced, or abnormal vision, corneal disorder, eye surface inflammation with or without surface damage, inflammation or infection of the conjunctiva, eye discharge, sensitivity to light, increased tear production, itchy eye, redness of the eye, eyelid abnormality, itching, redness, swelling, or crusting of the eyelid.
Croatian: Zamućen, smanjen, ili poremećen vid, poremećaj rožnice, upala površine oka sa ili bez oštećenja površine, upala ili infekcija konjunktive, iscjedak iz oka, osjetljivost na svjetlo, pojačano suzenje, svrbež oka, crvenilo oka, poremećaj vjeđe, svrbež, crvenilo, oticanje vjeđe ili stvaranje krusti na vjeđi.
English: Names and addresses of the manufacturer(s) responsible for batch release
Croatian: Naziv(i) i adresa(e) proizvođača odgovornog(ih) za puštanje serije lijeka u promet
English: Pull down your eyelid with a clean finger, until there is a ‘pocket' between the eyelid and your eye.
Croatian: Donju vjeđu lagano povucite prema dolje, tako da nastane džep između očne jabučice i same donje vjeđe (slika 1).
English: Close monitoring is required with frequent or prolonged use in dry eye patients, or in conditions where the cornea is compromised.
Croatian: Pri čestoj ili produženoj primjeni nužno je pažljivo praćenje bolesnika sa suhim očima ili kompromitiranom rožnicom.
English: Common eye pain, eye irritation, dry eye, abnormal sensation in eyes
Croatian: Često bol u oku, iritacija oka, suho oko, neobičan osjećaj u oku
English: General side effects Headache, fatigue, dry nose, bad taste.
Croatian: Opće nuspojave Glavobolja, umor, suhoća nosne sluznice, loš okus.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE OF ADMINISTRATION
Croatian: NAZIV LIJEKA I PUT (EVI) PRIMJENE LIJEKA
English: You may find that your vision is blurred for a time just after you use Opatanol.
Croatian: Moguće je privremeno zamagljenje vida odmah nakon primjene Opatanol kapi.
English: A renal impairment study after oral dosing of olopatadine has been performed in patients with severe renal impairment.
Croatian: Utjecaj oštećene funkcije bubrega nakon peroralno primijenjenog olopatadina istražen je u bolesnika s teškim oštećenjem bubrega.
English: Uncommon (may affect up to 1 in 100 people)
Croatian: Manje česte: mogu se pojaviti u manje od 1 na 100 osoba Nuspojave na oku
English: How to use Opatanol
Croatian: Kako primjenjivati Opatanol
English: Not known corneal oedema, eye oedema, eye swelling, conjunctivitis, mydriasis, visual disturbance, eyelid margin crusting
Croatian: Nepoznato edem rožnice, edem oka, oticanje oka, konjunktivitis, midrijaza, smetnje vida, stvaranje krusti na rubu vjeđe
English: Benzalkonium chloride 0.1 mg/ml.
Croatian: Pomoćna(e) tvar(i) s poznatim učinkom Benzalkonijev klorid 0,1 mg/ml
English: Eye swelling, corneal swelling, change in pupil size.
Croatian: Oticanje oka, oticanje rožnice, promjena u veličini zjenice.
English: General side effects Abnormal or decreased sensation, dizziness, runny nose, dry skin, skin inflammation.
Croatian: Opće nuspojave Promijenjena ili smanjena osjetljivost, omaglica, curenje nosa, suhoća kože, upalne promjene na koži.
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Croatian: Nuspojave možete prijaviti izravno putem nacionalnog sustava za za prijavu nuspojava: navedenog u Dodatku V.
English: Each mL of solution contains 1 mg of olopatadine (as hydrochloride).
Croatian: Svaki ml otopine sadrži 1 mg olopatadina (u obliku olopatadinklorida).
English: Opatanol 1 mg/mL eye drops olopatadine
Croatian: Opatanol 1 mg/ml kapi za oko. olopatadin
English: Eye pain, eye irritation, dry eye, abnormal eye sensation, eye discomfort.
Croatian: Bol u oku, nadražaj oka, suho oko, neugodan osjećaj u oku, nelagoda u oku.
English: Opatanol 1 mg/mL eye drops, solution
Croatian: Opatanol 1 mg/ml kapi za oko, otopina
English: Opatanol 1 mg/mL eye drops, solution olopatadine
Croatian: Opatanol 1 mg/ml kapi za oko, otopina olopatadin
English: Benzalkonium is known to discolour soft contact lenses.
Croatian: Poznato je da benzalkonijev klorid mijenja boju mekih kontaktnih leća.
English: In case of concomitant therapy with other topical ocular medicines, an interval of five minutes should be allowed between successive applications.
Croatian: Ako se primjenjuje više od jednog oftalmološkog lijeka za lokalnu primjenu, moraju se ukapati s najmanje 5 minuta razmaka između ukapavanja.
English: For ocular use only.
Croatian: Način primjene Samo za okularnu primjenu.
English: One mL of solution contains 1 mg olopatadine (as hydrochloride).
Croatian: Jedan ml otopine sadrži 1 mg olopatadina (u obliku olopatadinklorida).
English: Do not drive or use machines until this has worn off.
Croatian: Sve dok se vid ne razbistri nemojte upravljanje vozilima i strojevima.
English: 1 mL of solution contains 1 mg olopatadine (as hydrochloride).
Croatian: 1 ml otopine sadrži 1 mg olopatadina (u obliku olopatadinklorida).
English: - The other ingredients are benzalkonium chloride, sodium chloride, disodium phosphate dodecahydrate (E339), hydrochloric acid (E507) and/or sodium hydroxide (E524) and purified water.
Croatian: (E339) kloridna kiselina (E507) i/ili natrijev hidroksid (E524) i pročišćena voda.
English: Uncommon dermatitis contact, skin burning sensation, dry skin
Croatian: Poremećaji kože i potkožnog tkiva Manje često kontaktni dermatitis, osjećaj žarenja kože, suhoća kože
English: If you use more Opatanol than you should
Croatian: Ako primijenite više Opatanola nego što ste trebali Isperite oko s mlakom vodom.
English: Read the package leaflet before use.
Croatian: Prije primjene pročitajte Uputu o lijeku.
English: • You should not use OPATANOL if you are breast-feeding.
Croatian: • Ako dojite ne primjenjujte Opatanol.
English: • Bring the bottle tip close to the eye. Use the mirror if it helps.
Croatian: • Vrh kapaljke bočice približite oku.
English: Use in hepatic and renal impairment
Croatian: Primjena pri oštećenoj funkciji jetre i bubrega
English: Uncommon dizziness, hypoaesthesia
Croatian: Nepoznato astenija, malaksalost
English: Only use Opatanol in both eyes if your doctor told you to. Use it for as long as your doctor told you to.
Croatian: Lijek primjenite na oba oka samo ukoliko
English: Genotoxic and carcinogenic potential are not expected.
Croatian: Genotoksičan i karcinogen potencijal se ne očekuju.
English: The infusion will be given every two weeks.
Croatian: Infuzija se primjenjuje svaka dva tjedna.
English: 111 20 Stockholm
Croatian: 111 20 Stockholm Švedska
English: These results suggest the symptoms of the disease are improving or the disease is becoming stable.
Croatian: Ti rezultati upućuju na to da se simptomi bolesti poboljšavaju ili da bolest postaje stabilna.
English: It is not expected to bind to proteins.
Croatian: Ne očekuje se da se veže za proteine.
English: As with all protein pharmaceutical products, patients may develop antibodies to the protein.
Croatian: Kao i sa svim proteinskim lijekovima, bolesnici mogu razviti protutijela na protein.
English: These effects have decreased with time.
Croatian: Takve se reakcije smanjuju s vremenom.
English: For patients between 0 and 7 years of age, limited data indicate no specific safety issues.
Croatian: Za bolesnike u dobi od 0 do 7 godina ograničeni podaci ne ukazuju na specifične sigurnosne probleme.
English: This medicine should be applied and supervised by appropriately trained personnel, who will also calculate the dose that you will be given.
Croatian: Ovaj lijek treba primijeniti i primjenu nadzirati prikladno obučeno osoblje, koje će također izračunati dozu koju ćete primiti.
English: Date of last renewal: 03/08/2006
Croatian: Datum posljednje obnove: 03.08.2006.
English: Other medicines and Replagal
Croatian: Drugi lijekovi i Replagal
English: Pharmacokinetic parameters were not significantly different between male and female patients.
Croatian: Farmakokinetički parametri nisu se značajno razlikovali kod ženskih i muških bolesnika.
English: • For single use only.
Croatian: • Samo za jednokratnu uporabu.
English: Studies in patients over the age of 65 have not been performed and no dosage regimen can presently be recommended in these patients as safety and efficacy have not yet been established.
Croatian: Ispitivanja u bolesnika starijih od 65 godina nisu provedena i trenutno se ne može preporučiti ni jedan režim doziranja za te bolesnike jer još nije utvrđena sigurnost i djelotvornost.
English: Children and adolescents
Croatian: Djeca i adolescenati
English: However some effects may be serious and may need treatment.
Croatian: No, neke od nuspojava mogu biti ozbiljne i zahtijevati liječenje.
English: Based on limited data this percentage has been found to be lower (7%) in the male paediatric population.
Croatian: Na temelju ograničenih podataka utvrđeno je da je navedeni postotak niži (7 %) kod muške pedijatrijske populacije.
English: Currently available data are described in section 5.1 but no recommendation on posology can be made.
Croatian: Trenutno dostupni podaci opisani su u dijelu 5.1 međutim nije moguće dati preporuke o doziranju.
English: Non-clinical data reveal no special hazard for humans based on studies of repeated dose toxicity.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju ispitivanja toksičnosti ponovljenih doza.
English: What Replagal looks like and contents of the pack
Croatian: Kako Replagal izgleda i sadržaj pakiranja
English: Instructions for use, handling and disposal
Croatian: Upute za uporabu, rukovanje i uklanjanje
English: The safety and efficacy of Replagal in children aged 0-6 years has not yet been established.
Croatian: Sigurnost i djelotvornost Replagala u djece u dobi od 0 do 6 godina nisu još ustanovljene.
English: In such cases, the loss of renal function remains within the expected range of the natural progression of disease.
Croatian: U takvim slučajevima, gubitak bubrežne funkcije zadržava se u očekivanom rasponu prirodne progresije bolesti.
English: Very common: may affect more than 1 in 10 people - general pain or discomfort.
Croatian: Vrlo često: mogu se pojaviti u više od 1 na 10 osoba - opća bol ili nelagoda.
English: The experience in children 0-6 years old is limited and therefore no dose can be recommended for this age group.
Croatian: Iskustvo u djece od 0 do 6 godina je ograničeno i stoga nije moguće preporučiti dozu u toj dobnoj skupini.
English: It is not known whether Replagal crosses the placenta.
Croatian: Nije poznato prolazi li Replagal kroz placentu.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2 to 8°C, unless dilution has taken place in controlled and validated aseptic conditions.
Croatian: Ako se ne primijeni odmah, vrijeme i uvjeti čuvanja prije uporabe odgovornost su korisnika i uobičajeno ne smiju biti duži od 24 sata pri temperaturi od 2 do 8 °C, osim ako je razrjeđivanje provedeno u kontroliranim i validiranim aseptičkim uvjetima.
English: It is used as long-term enzyme replacement therapy when the level of enzyme in the body is absent or lower than normal as in Fabry Disease.
Croatian: Primjenjuje se kao dugoročna enzimska nadomjesna terapija kada je razina enzima u tijelu odsutna ili niža od normalne kao što je u Fabryjevoj bolesti.
English: Your doctor may also treat the symptoms with other medicines (antihistamines or corticosteroids).
Croatian: Liječnik može liječiti te simptome i drugim lijekovima (antihistaminicima ili kortikosteroidima).
English: Study with various dosing regimen
Croatian: Ispitivanje s raznim režimima doziranja
English: Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy or embryonic/fetal development when exposed during organogenesis (see Section 5.3).
Croatian: Ispitivanja na životinjama ne ukazuju na izravan ili neizravan štetan učinak lijeka na trudnoću ili embrionalni/fetalni razvoj uslijed izloženosti tijekom organogeneze (vidjeti dio 5.3).
English: Talk to your doctor or pharmacist before using Replagal.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primijenite Replagal.
English: The pharmacokinetic properties were essentially unaffected by the dose of the enzyme.
Croatian: Na farmakokinetička svojstva u suštini nije utjecala doza enzima.
English: Twelve to 18 months of treatment with Replagal resulted in improvement in quality of life (QoL), as measured by validated instruments.
Croatian: Dvanaest do 18 mjeseci liječenja Replagalom rezultiralo je poboljšanjem kvalitete života (QoL) koje je izmjereno validiranim mjernim instrumentima.
English: Replagal has no or negligible influence on the ability to drive and use machines.
Croatian: Replagal ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Once diluted, the solution should be mixed gently but not shaken.
Croatian: Kada se razrijedi, otopinu treba lagano promiješati, ali ne tresti.
English: In addition, oral or intravenous pre-treatment with antihistamines and/or corticosteroids, from 1 to 24 hours prior to infusion may prevent subsequent reactions in those cases where symptomatic treatment was required.
Croatian: Osim toga, peroralna ili intravenska premedikacija antihistaminicima i/ili kortikosteroidima od 1 do 24 sata prije infuzije može spriječiti neželjene reakcije u onim slučajevima u kojima je bilo potrebno primijeniti simptomatsko liječenje.
English: Tell your doctor if you use any medicines containing chloroquine, amiodarone, benoquin or gentamicin.
Croatian: Obavijestite liječnika ako primjenjujete bilo koje lijekove koji sadrže klorokin, amiodaron, benokvin ili gentamicin.
English: Agalsidase alfa is a protein.
Croatian: Agalzidaza alfa je protein.
English: Infusion of Replagal at home may be considered for patients who are tolerating their infusions well.
Croatian: Infuzija Replagala kod kuće može se razmotriti za bolesnike koji dobro podnose infuzije.
English: These IgG antibodies appeared to develop following approximately 3-12 months of treatment.
Croatian: Ova IgG protutijela stvaraju se nakon otprilike 3 - 12 mjeseci liječenja.
English: Antibodies to agalsidase alfa have not been shown to be associated with any clinically significant effects on safety (e.g. infusion reactions) or efficacy.
Croatian: Protutijela na agalzidazu alfa nisu pokazala povezanost s bilo kojim klinički značajnim učinkom na sigurnost (npr. infuzijske reakcije) ili djelotvornost.
English: The overall incidence of SAEs by treatment group did not show any obvious effect of treatment regimen on the SAE profile of the different treatment groups.
Croatian: Ukupna incidencija ozbiljnih nuspojava po liječenoj skupini nije pokazala nikakav očiti učinak režima liječenja na profil ozbiljnih nuspojava različitih liječenih skupina.
English: You may drive and use machines whilst on Replagal.
Croatian: Upravljanje vozilima i strojevima Možete voziti i raditi sa strojevima dok se liječite Replagalom.
English: In clinical studies of children (7-18 years) who received Replagal 0.2 mg/kg every other week, no unexpected safety issues were encountered (see section 5.1).
Croatian: U kliničkim ispitivanjima djece (7 - 18 godina) koja su dobivala Replagal 0,2 mg/kg svaki drugi tjedan nisu se pojavila neočekivana sigurnosna pitanja (vidjeti dio 5.1).
English: Limited data are available in patients on dialysis or post-kidney transplantation, no dose adjustment is recommended.
Croatian: Ograničeni podaci dostupni su kod bolesnika na dijalizi ili nakon transplantacije bubrega; nije preporučena prilagodba doze.
English: Reproduction toxicity studies in female rats and rabbits have shown no effect on pregnancy or the developing foetus.
Croatian: Ispitivanja reproduktivne toksičnosti u ženki štakora i zečeva nisu pokazale učinak na trudnoću ili razvoj fetusa.
English: Antibodies to the protein
Croatian: Protutijela na protein
English: About 1 out of 7 patients (frequency “very common”) may have a reaction during or following an infusion of Replagal (infusion related reaction).
Croatian: Kod otprilike 1 od 7 (učestalost „vrlo često“) bolesnika mogu se javiti reakcije tijekom ili nakon infuzije Replagala (reakcija povezana s infuzijom).
English: 4.6 Effects on ability to drive and use machines
Croatian: 4.7 Utjecaj na sposobnost upravljanja vozilima i rada sa strojevima
English: The current medical standards for emergency treatment are to be observed.
Croatian: Potrebno je razmotriti primjenu standardnih medicinskih postupaka za liječenje hitnih stanja.
English: PHARMACEUTICAL FORM AND CONTENTS 1 x 3.5 ml concentrate for solution for infusion 4 x 3.5 ml concentrate for solution for infusion 10 x 3.5 ml concentrate for solution for infusion
Croatian: OBLIK I SADRŽAJ 1 x 3,5 ml koncentrat za otopinu za infuziju 4 x 3,5 ml koncentrat za otopinu za infuziju 10 x 3,5 ml koncentrat za otopinu za infuziju
English: The occurrence of an event in a single patient is defined as uncommon in view of the number of patients treated.
Croatian: Pojava događaja kod pojedinačnih pacijenata definira se kao manje česta s obzirom na broj liječenih bolesnika.
English: What you need to know before Replagal is given
Croatian: Što morate znati prije nego počnete primati Replagal
English: Elimination half-lives were 108 ± 17 minutes in males compared to 89 ± 28 minutes in females and volume of distribution was approximately 17% body weight in both sexes.
Croatian: Poluvrijeme eliminacije kod muškaraca iznosilo je 108 ± 17 minuta, dok je kod žena iznosilo 89 ± 28 minuta, a volumen distribucije iznosio je otprilike 17 % tjelesne težine kod oba spola.
English: Following a single intravenous dose of 0.2 mg/kg, agalsidase alfa had a biphasic distribution and elimination profile from the circulation.
Croatian: Nakon pojedinačne intravenske doze od 0,2 mg/kg, agalzidaza alfa imala je bifazični profil distribucije i eliminacije iz cirkulacije.
English: If you notice any of these effects during or after an infusion you should tell your doctor immediately: - high fever, chills, sweating, fast heart rate; - vomiting; - light-headedness; - hives;
Croatian: Ako osjetite bilo koji od ovih učinaka tijekom ili nakon infuzije, morate odmah obavijestiti svog liječnika: - visoku vrućicu, zimicu, znojenje, ubrzani rad srca; - povraćanje; - ošamućenost;
English: Infusion related reactions have been experienced by 9 patients of the naïve population (31.0%) compared to 27 patients of the switched population (38.0%).
Croatian: Reakcije povezane s infuzijom doživjelo je 9 bolesnika iz prethodno neliječene populacije (31,0 %) u usporedbi sa 27 bolesnika iz populacije koja je promijenila lijek (38,0 %).
English: - swelling in your hands, feet, ankles, face, lips, mouth or throat which may cause difficulty in swallowing or breathing.
Croatian: - oticanje ruku, stopala, gležnjeva, lica, usana, usta ili grla što može izazvati otežano gutanje ili disanje.
English: Data with patients indicates that at least 0.1mg/kg is required to achieve a pharmacodynamics response.
Croatian: Podaci s bolesnicima pokazuju da je potrebno najmanje 0,1 mg/kg za postizanje farmakodinamičkog odgovora.
English: In a second study, in 14 patients ≥ 7 years of age, the results regarding heart rate variability were consistent with previous findings.
Croatian: drugom ispitivanju, kod 14 bolesnika ≥ 7 godina, rezultati o varijabilnosti srčane frekvencije bili su dosljedni s prethodnim nalazima.
English: If you have advanced renal disease, you may find that your Replagal treatment has a limited effect on your kidneys.
Croatian: Ako imate uznapredovalu bubrežnu bolest, možda će vaše liječenje Replagalom imati ograničeni učinak na vaše bubrege.
English: A clear and colourless solution.
Croatian: Bistra i bezbojna otopina.
English: Chemical and physical in use stability has been demonstrated for 24 hours at 25°C.
Croatian: Dokazana je kemijska i fizička stabilnost u primjeni tijekom 24 sata na 25 °C.
English: There is a theoretical risk of decreased agalsidase alfa activity.
Croatian: Postoji teorijska opasnost od smanjenja aktivnosti agalzidaze alfa.
English: The metabolic effects were also associated with clinically significant weight gain, increased sweating and increased energy.
Croatian: Metabolički učinci bili su povezani s klinički značajnim povećanjem tjelesne težine, pojačanjem znojenja i povećanjem energije.
English: Caution should be exercised when prescribing to pregnant women.
Croatian: Oprez je nužan pri propisivanju trudnicama.
English: Information is presented by system organ class and frequency (very common ≥1/10; common ≥1/100 to <1/10; uncommon ≥1/1,000 to <1/100).
Croatian: Podaci su prikazani prema klasifikaciji organskih sustava i učestalosti nuspojava (vrlo često ≥1/10, često ≥1/100 i <1/10, manje često ≥1/1000 i <1/100).
English: Children and adolescents may be more likely than adults to experience an infusion related reaction.
Croatian: U djece i adolescenata veća je vjerojatnost pojave reakcije povezane s infuzijom nego u odraslih.
English: For children and adolescents 7-18 years old a dose of 0.2 mg/kg every other week may be used.
Croatian: Kod djece i adolescenata u dobi od 7 do 18 godina može se koristiti doza od 0,2 mg/kg svaki drugi tjedan.
English: The remaining 76% were antibody negative throughout.
Croatian: Ostalih 76 % bolesnika su tijekom cijelog liječenja bili negativni na protutijela.
English: As metabolism is expected to occur by peptide hydrolysis, impaired liver function is not expected to affect the pharmacokinetics of agalsidase alfa in a clinically significant manner.
Croatian: Budući da je očekivani metabolizam razgradnje hidroliza peptida, ne očekuje se da će oštećenje funkcije jetre utjecati na farmakokinetiku agalzidaze alfa na klinički značajan način.
English: However, the chemical and physical stability of the diluted solution has been demonstrated for 24 hours at 25°C.
Croatian: Međutim, kemijska i fizička stabilnost razrijeđene otopine dokazana je tijekom 24 sata pri 25 °C.