FrancophonIA/ELRC3.0 huggingface dataset:
English: Each carton contains 10 x 1 tablets in OPA/Aluminium /PVC-Aluminium perforated unit dose blister.
Maltese: Kull kartuna fiha 10 x 1 pilloli f'folja tal-OPA/Aluminju/PVC-Aluminju mtaqqba għal dożi waħedhom.
English: • With medicinal products that carry a risk of Torsades de Pointes, due to increased risk of ventricular arrhythmia.
Maltese: • Ma' prodotti mediċinali li jġorru r-riskju ta' Torsades de Pointes, minħabba ż-żieda fir-riskju ta' arritmija ventrikolari.
English: The combination of lenalidomide, thalidomide or pomalidomide with dexamethasone is associated with an increased risk of deep vein thrombosis and pulmonary embolism in patients with multiple myeloma (see section 4.5).
Maltese: Il-kombinazzjoni ta' lenalidomide, thalidomide jew pomalidomide ma' dexamethasone hija assoċjata ma' żieda fir-riskju ta' trombożi fil-vini fondi u emboliżmu pulmonari fil-pazjenti b'majeloma multipla (ara sezzjoni 4.5).
English: Respiratory, thoracic, or mediastinal disorders
Maltese: Disturbi respiratorji, toraċiċi u medjastinali
English: At doses ≥ 500 mg per dose or < 3 g per day, precautions are required due to increased risk of haemorrhage, ulcerations and gastro-intestinal perforation.
Maltese: B'dożi ta' ≥ 500 mg għal kull doża jew < 3 g kuljum, huma meħtieġa prekawzjonijiet minħabba żieda fir-riskju ta' emorraġija, ulċerazzjonijiet u perforazzjoni gastro-intestinali.
English: When Neofordex is used in combination with known teratogens (e.g. thalidomide, lenalidomide, pomalidomide, plerixafor), particular attention to pregnancy testing and prevention requirements is needed (see section 4.6).
Maltese: Meta Neofordex jintuża flimkien ma' teratoġeni magħrufa (eż. thalidomide, lenalidomide, pomalidomide, plerixafor), hija meħtieġa attenzjoni partikolari għar-rekwiżiti tal-ittestjar u l-prevenzjoni tat-tqala (ara sezzjoni 4.6).
English: No chronic toxicity and carcinogenicity data are available.
Maltese: Mhix disponibbli data dwar it-tossiċità kronika u lkarċinoġenità.
English: • Indinavir, due to a strong reduction of indinavir plasma levels by intestinal CYP3A4 induction.
Maltese: • Indinavir, minħabba tnaqqis qawwi fil-livelli ta' indinavir fil-plażma permezz tal-induzzjoni intestinali ta' CYP3A4.
English: Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation.
Maltese: Kien meħtieġ esponiment fit-tul sabiex jinkisbu livelli massimi ta' markers apoptotiċi flimkien ma' attivazzjoni akbar ta' caspase-3 u frammentazzjoni tad-DNA.
English: Uncommon: Cerebrovascular accident, transient ischaemic attack, amnesia, coordination abnormal, ataxia, syncope;
Maltese: Mhux komuni: Aċċident ċerebrovaskulari, attakk iskemiku temporanju, amnesija, koordinazzjoni anormali, atassja, sinkope;
English: In patients with multiple myeloma, the combination of dexamethasone with thalidomide and its analogues is associated with an increased risk of venous thromboembolism (predominantly deep vein thrombosis and pulmonary embolism) and arterial thromboembolism (predominantly myocardial infarction and cerebrovascular event) (see sections 4.5 and 4.8).
Maltese: F'pazjenti b'majeloma multipla, il-kombinazzjoni ta' dexamethasone ma' thalidomide u l-analogi tiegħu hija assoċjata ma' żieda fir-riskju ta' tromboemboliżmu fil-vini (prinċipalment trombożi fil-vini fondi u emboliżmu pulmonari) u tromboemboliżmu arterjali (prinċipalment infart mijokardijaku u avveniment ċerebrovaskulari) (ara sezzjonijiet 4.5 u 4.8).
English: What Neofordex contains - The active substance is dexamethasone.
Maltese: X'fih Neofordex - Is-sustanza attiva hi dexamethasone.
English: • Isoniazid, as glucocorticoids may decrease isoniazid plasma concentrations, probably due to a stimulation of hepatic metabolism of isoniazid and a reduction of glucocorticoid metabolism.
Maltese: • Isoniazide, billi l-glukokortikojdi jistgħu jnaqqsu l-konċentrazzjonijiet ta' isoniazidfil-plażma, x'aktarx minħabba stimulazzjoni tal-metaboliżmu epatiku ta' isoniazid u tnaqqis fil-metaboliżmu talglukokortikojdi.
English: Do not take Neofordex
Maltese: Tiħux Neofordex
English: Swallow the prescribed dose of one tablet (40 mg) or half a tablet (20 mg) in the morning with a glass of water.
Maltese: Ibla d-doża preskritta ta' pillola waħda (40 mg) jew nofs pillola (20 mg) filgħodu ma' tazza ilma.
English: Manufacturer
Maltese: Trasportaturi
English: Not known: Adrenal atrophy, steroid withdrawal syndrome, adrenal insufficiency, hirsutism, menstrual irregularity.
Maltese: Atrofija adrenali, sindrome tal-irtirar tal-isterojdi, insuffiċjenza adrenali, irsutiżmu, irregolarità mestrwali.
English: Tumour lysis syndrome
Maltese: Is-sindrome tal-lisi tat-tumur
English: Effects of dexamethasone on other medicinal products Dexamethasone is a moderate inducer of CYP3A4 and of P-gp.
Maltese: Dexamethasone huwa induttur moderat ta' CYP3A4 u tal-P-gp.
English: Use of corticosteroids requires appropriate monitoring in patients with ulcerative colitis (due to perforation risk), recent intestinal anastomoses, diverticulitis, recent myocardial infarction (risk of left ventricular free wall rupture), diabetes mellitus (or family history), renal insufficiency, hepatic impairment, osteoporosis and myasthenia gravis.
Maltese: L-użu tal-kortikosterojdi jeħtieġ monitoraġġ xieraq fil-pazjenti b'kolite ulċerattiva (minħabba r-riskju ta' perforazzjoni), anastomożi reċenti tal-imsaren, divertikulite, infart mijokardijaku reċenti (riskju ta' fqigħ tal-ħajt liberu tal-ventrikolu tax-xellug), dijabete mellitus (jew storja fil-familja), insuffiċjenza renali, indeboliment epatiku, osteoporożi u myasthenia gravis.
English: − Increased pressure in the eye including glaucoma, choroid and retinal disorders (chorioretinopathy);
Maltese: − Żieda fil-pressjoni tal-għajn inkluża glawkoma, korojde u disturbi fir-retina (korijoretinopatija);
English: The combination of dexamethasone with lenalidomide in multiple myeloma patients is associated with a higher incidence of grade 3 and grade 4 thrombocytopenia (9.9% and 1.4%, respectively, in lenalidomide/dexamethasone-treated patients compared to 2.3% and 0.0% in placebo/dexamethasone-treated patients) (see section 4.8).
Maltese: Il-kombinazzjoni ta' dexamethasone ma' lenalidomide f'pazjenti b'majeloma multipla hija assoċjata ma' inċidenza akbar ta' tromboċitopenija ta' grad 3 u grad 4 (9.9% u 1.4%, rispettivament, fil-pazjenti li ngħataw lenalidomide/dexamethasone meta mqabbel ma' 2.3% u 0.0% fil-pazjenti li ngħataw plaċebo/dexamethasone) (ara sezzjoni 4.8).
English: Common: Depression, anxiety, aggression, confusional state, irritability, nervousness, mood alteration, agitation, euphoric mood; Uncommon: Mood swings, hallucinations;
Maltese: Komuni: Depressjoni, ansjetà, aggressjoni, stat ta' konfużjoni, irritabbiltà, nervożiżmu, bidla fil-burdata, aġitazzjoni, burdata ewforika;
English: • Ivermectin, due to a reduction of ivermectin plasma levels.
Maltese: • Ivermectin, minħabba tnaqqis fil-livelli ta' ivermectin fil-plażma.
English: In one study, 10.7% of patients treated with thalidomide and dexamethasone experienced grade 3/4 neuropathic reactions, compared to 0.9% of patients treated with dexamethasone alone.
Maltese: Fi studju wieħed, 10.7% tal-pazjenti li ngħataw thalidomide u dexamethasone kellhom reazzjonijiet newropatiċi ta' grad 3/4, meta mqabbel ma' 0.9% tal-pazjenti li ngħataw dexamethasone waħdu.
English: • With hypokalaemic medicinal products: hypokalemic diuretics, single or in combination, laxatives, tetracosactide, intravenous amphotericin B, due to increased risk of hypokalaemia.
Maltese: • Ma' prodotti mediċinali ipokalimiċi: id-dijuretiċi ipokalimiċi, waħedhom jew f'kombinazzjoni, illassattivi, tetracosactide, amphotericin B fil-vini, minħabba żieda fir-riskju ta' ipokalimja.
English: − Medicinal products that may reduce dexamethasone plasma concentration:
Maltese: − Prodotti mediċinali li jistgħu jżidu l-konċentrazzjoni ta' dexamethasone fil-plażma:
English: Dexamethasone is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity.
Maltese: Dexamethasone huwa glukokortikojd sintetiku; huwa jgħaqqad effetti antiifjammatorji qawwija ma' attività mineralokortikojdi baxxa.
English: In Pom + LD-Dex treated patients, thrombocytopenia was serious in 1.7% of patients, led to dose reduction in 6.3% of patients, to dose interruption in 8% of patients and to treatment discontinuation in 0.7% of patients.
Maltese: F'pazjenti kkurati b'Pom + LD-Dex, tromboċitopenija kienet serja f'1.7% tal-pazjenti, waslet għal tnaqqis tad-doża f'6.3% tal-pazjenti, ma' interruzzjoni tad-doża fi 8% tal-pazjenti u għal waqfien tal-kura f'0.7% tal-pazjenti.
English: The efficacy of oral contraceptives may be reduced during dexamethasone treatment (see section 4.5).
Maltese: L-effikaċja tal-kontraċettivi orali tista' titnaqqas waqt il-kura b'dexamethasone (ara sezzjoni 4.5).
English: Dexamethasone is bound by plasma proteins, principally albumin, up to about 80%, depending on the administered dose.
Maltese: Dexamethasone jeħel mal-proteini tal-plażma, prinċipalment l-albumina, sa madwar 80%, skont id-doża mogħtija.
English: • Ciclosporin, due to a reduction of ciclosporin bioavailability and plasma levels.
Maltese: • Ciclosporin, minħabba tnaqqis fil-bijodisponibbiltà u l-livelli fil-plażma ta' ciclosporin.
English: Neofordex 40 mg tablet Dexamethasone
Maltese: Neofordex 40 mg pillola dexamethasone
English: The combination of lenalidomide with dexamethasone in relapsed or refractory multiple myeloma patients is associated with a higher incidence of grade 3 and grade 4 thrombocytopenia (9.9% and 1.4%, respectively, in lenalidomide/dexamethasone-treated patients compared to 2.3% and 0.0% in placebo/dexamethasone-treated patients).
Maltese: Il-kombinazzjoni ta' lenalidomide ma' dexamethasone f'pazjenti li għandhom majeloma multipla li reġgħet tfaċċat jew li kienet refrattorja hija assoċjata ma' inċidenza ogħla ta' tromboċitopenija ta' grad 3 u grad 4 (9.9% u 1.4%, rispettivament, fil-pazjenti li ngħataw lenalidomide/dexamethasone meta mqabbel ma' 2.3% u 0.0% filpazjenti li ngħataw placebo/dexamethasone).
English: Common: Pneumonia, herpes zoster, upper respiratory tract infection, lower respiratory tract infection, oral candidiasis, oral fungal infection, urinary tract infection, herpes simplex, candidal infection;
Maltese: Infezzjonijiet u infestazzjonijiet Komuni: Pulmonite, herpes zoster, infezzjoni fil-parti ta' fuq talapparat respiratorju, infezzjoni fil-parti ta' isfel tal-apparat respiratorju, kandidijasi orali, infezzjoni fungali fil-ħalq, infezzjoni fl-apparat tal-awrina, herpes simplex, infezzjoni kandidali;
English: Grade 4 febrile neutropenia episodes were observed infrequently (0.6% in lenalidomide/dexamethasone-treated patients compared to 0.0% in placebo/dexamethasone treated patients; see section 4.8).
Maltese: Episodji ta' newtropenija bid-deni ta' grad 4 kienu osservati b'mod mhux frekwenti (0.6% fil-pazjenti li ngħataw lenalidomide/dexamethasone meta mqabbel ma' 0.0% fil-pazjenti li ngħataw plaċebo/dexamethasone; ara sezzjoni 4.8).
English: Neofordex 40 mg tablets dexamethasone
Maltese: Neofordex 40 mg pilloli dexamethasone
English: Repeated, daily administration of dexamethasone also leads to reduced dexamethasone plasma levels due to the induction of CYP3A4 and P-gp.
Maltese: L-għoti kuljum, ripetut ta' dexamethasone jwassal ukoll għal tnaqqis fil-livelli ta' dexamethasone fil-plażma minħabba l-induzzjoni ta' CYP3A4 u tal-P-gp.
English: Neutropenia occurred in 45.3% of relapsed and refractory multiple myeloma patients who received low dose dexamethasone plus pomalidomide (Pom + LD-Dex), and in 19.5% of patients who received high dose dexamethasone (HD-Dex).
Maltese: Newtropenja seħħet f'45.3% tal-pazjenti b'majeloma multipla li reġgħet tfaċċat/refrattarja li rċevew doża baxxa ta' dexamethasone flimkien ma' pomalidomide (Pom + LD-Dex), u f'19.
English: In addition, amphotericin B carries a risk of cardiac enlargement and cardiac failure with concurrent use.
Maltese: Barra minn hekk, l-amphotericin B iġorr irriskju ta' tkabbir kardijaku u insuffiċjenza kardijaka bl-użu konkomitanti.
English: − Pain, fever, chills, fainting, vertigo, exhaustion, drowsiness, impaired sense of balance.
Maltese: − Uġigħ, deni, kesħa, ħass ħażin, vertigo, eżawriment, ngħas, indeboliment tas-sens tal-bilanċ.
English: The combination of dexamethasone with lenalidomide in multiple myeloma patients is associated with a higher incidence of grade 4 neutropenia (5.1% in lenalidomide/dexamethasone-treated patients compared with 0.6% in placebo/dexamethasone-treated patients; see section 4.8).
Maltese: Il-kombinazzjoni ta' dexamethasone ma' lenalidomide f'pazjenti b'majeloma multipla hija assoċjata ma' inċidenza akbar ta' newtropenija ta' grad 4 (5.1% fil-pazjenti li ngħataw lenalidomide/dexamethasone meta mqabbel ma' 0.6% fil-pazjenti li ngħataw plaċebo/dexamethasone; ara sezzjoni 4.8).
English: Prophylactic antithrombotic treatment should be recommended, especially in patients with additional thrombotic risk factors.
Maltese: Għandha tiġi rrakkomandata kura profilattika kontra ttrombożi, speċjalment f'pazjenti li jkollhom fatturi ta' riskju trombotiċi addizzjonali.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Maltese: Pazjenti li għandhom problemi ereditarji serji ta' intolleranza għall-galactose, nuqqas ta' Lapp lactase jew malassorbiment tal-glucose-galactose m'għandhomx jieħdu din il-mediċina.
English: Thrombocytopenia occurred in 27.0% of relapsed and refractory multiple myeloma patients who received Pom + LD-Dex, and 26.8% of patients who received HD-Dex.
Maltese: Tromboċitopenja seħħet f'27.0% tal-pazjenti b'majeloma multipla li reġgħet tfaċċat/refrattarja li rċevew Pom + LD-Dex, u 26.
English: Uncommon: Myocardial ischaemia, bradycardia; Not known: Congestive heart failure.
Maltese: Mhux komuni: Iskemija mijokardijaku, bradikardija; Mhux magħruf:
English: Neofordex contains lactose.
Maltese: Neofordex fih il-lattożju.
English: • Topical gastro-intestinal medicinal products, antacids and activated carbon, as well as colestyramine, due to reduction of the intestinal absorption of dexamethasone.
Maltese: • Prodotti mediċinali gastro-intestinali, l-antaċidi u l-karbonju attivat, kif ukoll colestyramine, minħabba tnaqqis fl-assorbiment intestinali ta' dexamethasone.
English: Neofordex will be given with other medicines for multiple myeloma.
Maltese: Neofordex se jingħata ma' mediċini oħra għall-majeloma multipla.
English: • Aprepitant and fosaprepitant, due to an increase of dexamethasone plasma concentrations by a reduction of its hepatic metabolism.
Maltese: • Aprepitantu fosaprepitant, minħabba żieda fil-konċentrazzjonijiet ta' dexamethasone fil-plażma permezz ta' tnaqqis fil-metaboliżmu epatiku tiegħu.
English: Common: Bronchitis, cough, dyspnoea, pharyngolaryngeal pain, hoarseness, hiccough.
Maltese: Komuni: Bronkite, sogħla, dispneja, uġigħ fil-farinġi u l-larinġi, ħanqa, sulluzzu.
English: The adverse reactions observed in patients treated with dexamethasone are listed below by system organ class and frequency.
Maltese: Ir-reazzjonijiet avversi osservati fil-pazjenti li ngħataw dexamethasone huma elenkati hawn taħt skont is-sistema tal-klassifika tal-organi u l-frekwenza.
English: When Neofordex is given in combination with other medicinal products, refer to their Summaries of Product Characteristics for additional contraindications.
Maltese: Meta Neofordex jingħata ma' prodotti mediċinali oħra, irreferi għas-Sommarji tal-Karatteristiċi tal-Prodott tagħhom għal kontraindikazzjonijiet addizzjonali.
English: Common: Rash, erythema, hyperhidrosis, pruritus, dry skin, alopecia;
Maltese: Raxx, eritema, iperidrosi, prurite, ġilda xotta, alopeċja;
English: Each tablet contains dexamethasone acetate equivalent to 40 mg dexamethasone.
Maltese: Kull pillola fiha dexamethasone acetate ekwivalenti għal 40 mg dexamethasone.
English: Bioavailability of dexamethasone is approximately 80%.
Maltese: Il-bijodisponibbiltà ta' dexamethasone hija bejn wieħed u ieħor ta' 80%.
English: Low-grade peripheral neuropathic reactions, predominantly grade 1 paraesthesia, may be observed with dexamethasone alone in up to 34% of newly diagnosed multiple myeloma patients.
Maltese: Reazzjonijiet ta' newropatija periferali ta' grad baxx, prinċipalment parasteżija ta' grad 1, jistgħu jkunu osservati b'dexamethasone waħdu f'sa 34% tal-pazjenti dijanjostikati ġodda b'majeloma multipla.
English: No differences were found in dexamethasone pharmacokinetics between subjects of European and Asian (Indonesian and Japanese) descent.
Maltese: Ma nstabux differenzi filfarmakokinetika ta' dexamethasone bejn suġġetti ta' nisel Ewropew u ta' nisel Asjatiku (Indoneżjani u Ġappuniżi).
English: The combination of dexamethasone with thalidomide, lenalidomide or pomalidomide (medicines to treat multiple myeloma) increases the risk of blood clots in the veins and arteries.
Maltese: Ilkombinazzjoni ta' dexamethasone ma' thalidomide, lenalidomide jew pomalidomide (mediċini għall-kura talmajeloma multipla) iżżid ir-riskju tal-emboli fil-vini u l-arterji.
English: • Rifabutin, due to reduced rifabutin plasma levels by induction of intestinal and hepatic CYP3A4.
Maltese: • Rifabutin, minħabba t-tnaqqis fil-livelli ta' rifabutin fil-plażma permezz tal-induzzjoni ta' CYP3A4 intestinali u epatiku.
English: • With hypoglycaemic medicinal products, as dexamethasone can raise glycaemic levels and diminish glucose tolerance, with a possibility of ketoacidosis.
Maltese: • Ma' prodotti mediċinali ipogliċemiċi, billi dexamethasone jista' jgħolli l-livelli gliċemiċi u jnaqqas ittolleranza għall-glukożju, bil-possibbiltà ta' ketoaċidożi.
English: Methotrexate is also used to treat rheumatism or psoriasis; - Erythropoietin (EPO, to treat anaemia) - Ciclosporin (for the treatment of psoriasis, atopic dermatitis, rheumatoid arthritis or nephrotic syndrome, and to suppress immune reactions after an organ or bone marrow transplantation) - Ephedrine (to treat asthma attacks or relieve nasal congestion).
Maltese: Ciclosporin (għall-kura tal-psorjasi, id-dermatite atopika, l-artrite rewmatika jew is-sindrome nefrotiku, u għat-trażżin tar-reazzjonijiet immunitarji wara trapjant ta' organu jew tal-mudullun) Ephedrine (għall-kura tal-attakki tal-ażżma jew biex itaffi l-konġestjoni fl-imnieħer).
English: During treatment, a diet low in simple sugars and high in protein should be followed due to the hyperglycaemic effect of corticosteroids and their stimulation of protein catabolism with a negative nitrogen balance.
Maltese: Matul il-kura, għandha tiġi segwita dieta baxxa fiz-zokkor sempliċi u għolja fil-proteini minħabba l-effett ipergliċemiku tal-kortikosterojdi u l-istimulazzjoni li jagħmlu tal-kataboliżmu tal-proteini b'bilanċ negattiv tannitroġenu.
English: Talk to your doctor before taking Neofordex - if you have liver or kidney disease, - if you have heart disease or you have recently had a heart attack, - if you have high blood pressure, high cholesterol or you are a smoker, - if you have diabetes or if there is a history of diabetes in your family, - if you have osteoporosis, especially if you are a woman who has been through the menopause, - if you have glaucoma (increased eye pressure) or if there is a history of glaucoma in your family, - if you have myasthenia gravis (a disease affecting the muscles), - if you have a peptic ulcer (ulcer in your stomach or duodenum), or a history of peptic ulcers, stomach bleeding or perforation, - if you have inflammation of the colon, diverticulitis, or have recently had surgery on the intestine, - if you have inflammation of a tendon.
Maltese: Kellem lit-tabib tiegħek qabel tieħu Neofordex: jekk għandek mard tal-fwied jew tal-kliewi, jekk għandek mard tal-qalb jew jekk dan l-aħħar tak attakk tal-qalb, jekk għandek pressjoni tad-demm għolja, kolesterol għoli jew tpejjep, jekk għandek id-dijabete jew jekk hemm storja ta' dijabete fil-familja tiegħek, jekk għandek l-osteoporożi, speċjalment jekk inti mara li għaddejt mill-menopawsa, jekk għandek il-glawkoma (żieda fil-pressjoni tal-għajn) jew jekk hemm storja ta' glawkoma fil-familja tiegħek. jekk għandek myasthenia gravis (marda li taffettwa l-muskoli),
English: FN was reported to be serious in 4.0% of patients.
Maltese: FN kienet irrapportata bħala serja f'4.0% tal-pazjenti.
English: Common: Vomiting, diarrhoea, nausea, dyspepsia, stomatitis, gastritis, abdominal pain, dry mouth, abdominal distension, flatulence;
Maltese: Komuni: Rimettar, dijarea, nawżja, dispepsja, stomatite, gastrite, uġigħ addominali, ħalq xott, distensjoni addominali, gass flistonku;
English: − Inability of the body to respond normally to severe stress such as accidents, surgery or illness due to insufficient function of the adrenal glands, severe unusual headache with visual disturbances linked to the withdrawal of treatment, irregularity of menstrual cycles in women;
Maltese: − Inkapaċità tal-ġisem li jirrispondi b'mod normali għal stress sever bħal aċċidenti, kirurġija jew mard minħabba funzjoni insuffiċjenti tal-glandoli adrenali, uġigħ ta' ras sever mhux tas-soltu b'disturbi tal-vista marbuta mal-irtirar tal-kura, irregolarità taċ-ċikli mestrwali fin-nisa;
English: High-dose corticosteroids, including dexamethasone, can cause psychological problems that may sometimes be serious.
Maltese: Il-kortikosterojdi ta' doża għolja, inkluż dexamethasone, jistgħu jikkawżaw problemi psikoloġiċi li xi drabi jistgħu jkunu serji.
English: Common: Pollakiuria; Uncommon: Renal failure.
Maltese: Komuni: Pollakurja; Mhux komuni:
English: Concomitant administration of dexamethasone with substances that are metabolised via CYP3A4 or transported by P-gp could lead to increased clearance and decreased plasma concentrations of these substances:
Maltese: L-għoti konkomitanti ta' dexamethasone ma' sustanzi li jiġu metabolizzati permezz ta' CYP3A4 jew trasportati permezz tal-P-gp jista' jwassal għal żieda fittneħħija u tnaqqis fil-konċentrazzjonijiet fil-plażma ta' dawn is-sustanzi:
English: Systemic treatment with glucocorticoids can induce chorioretinopathy which may result in impaired vision including loss of vision.
Maltese: Kura sistemika b'glukokortikojdi tista' tikkaġuna korijoretinopatija li tista'tirriżulta f'indeboliment tal-vista inkluż telf tal-vista.
English: In combination with thalidomide or its analogues the most serious adverse reactions were venous thromboembolic events, predominantly deep vein thrombosis and pulmonary embolism, and myelosuppression, particularly neutropenia and thrombocytopenia (see section 4.4).
Maltese: F'kombinazzjoni ma' thalidomide jew l-analogi tiegħu, ir-reazzjonijiet l-aktar avversi serji kienu lavvenimenti tromboemboliċi fil-vini, prinċipalment trombożi fil-vini fondi u emboliżmu pulmonari, u majelosoppressjoni, b'mod partikolari newtropenija u tromboċitopenija (ara sezzjoni 4.4).
English: Common: may affect up to 1 in 10 people
Maltese: Komuni ħafna: jistgħu jaffettwaw aktar minn 1 minn kull 10 persuni
English: Each tablet contains dexamethasone acetate, equivalent to 40 mg dexamethasone.
Maltese: Kull pillola fiha dexamethasone acetate, ekwivalenti għal 40 mg dexamethasone. Eċċipjent b'effett magħruf:
English: Concomitant use of dexamethasone and ciclosporine should be avoided.
Maltese: L-użu konkomitanti ta' dexamethasone u ciclosporine għandu jiġi evitat.
English: Not known: Pathological fracture, osteonecrosis, osteoporosis, tendon rupture.
Maltese: Ksur patoloġiku, osteonekrożi, osteoporosi, tiċrit tal-għerq.
English: Your doctor will advise on an appropriate diet, and may prescribe potassium, calcium or vitamin D supplements.
Maltese: It-tabib tiegħek se jagħtik parir dwar dieta xierqa, u jista' jordnalek supplementi tal-potassju, tal-kalċju jew tal-vitamina D.
English: Less common but serious adverse reactions include: pneumonia and other infections and psychiatric disorders (see section 4.4).
Maltese: Reazzjonijiet avversi anqas komuni iżda serji jinkludu: pulmonite u infezzjonijiet oħra u disturbi psikjatriċi (ara sezzjoni 4.4).