FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Commission granted a marketing authorisation valid throughout the European Union, for Zuprevo on 6 May 2011.
Estonian: Euroopa Komisjon andis Zuprevo müügiloa, mis kehtib kogu Euroopa Liidu territooriumil, 6. mail 2011.
English: Zuprevo tildipirosin
Estonian: Zuprevo tildipirosiin
English: The medicine should not be given into a blood vessel.
Estonian: Ravimit ei tohi süstida veresoonde.
English: In case of accidental contact, the skin should be washed immediately with soap and water, and the eyes flushed with clean water.
Estonian: Juhuslikul nahale sattumisel tuleb nahka otsekohe pesta seebi ja veega ning silmi loputada puhta veega.
English: Zuprevo is a veterinary medicine that contains tildipirosin.
Estonian: Zuprevo on veterinaarravim, mis sisaldab tildipirosiini.
English: This medicine is not allowed to be used in animals producing milk for human consumption.
Estonian: Ravimit ei tohi kasutada loomadel, kelle piima tarvitatakse inimtoiduks.
English: The animal should be monitored and if signs of respiratory problems are still present after two days (pigs) or two to three days (cattle), the treatment should be switched to another antibiotic.
Estonian: Loomi tuleb jälgida ja kui sigadel esineb 2 päeva ja veistel 2-3 pärast süstimist endiselt hingamisteede probleemid, tuleb üle minna muule antibiootikumravile.
English: Zuprevo is available as a solution for injection containing tildipirosin 40 mg/ml (for pigs) or 180 mg/ml (for cattle).
Estonian: Zuprevot turustatakse süstelahusena, mis sisaldab 40 mg/ml (sigadele) või 180 mg/ml (veistele) tildipirosiini.
English: Zuprevo should only be used when the bacteria are sensitive to tildipirosin.
Estonian: Zuprevot tohib kasutada üksnes siis, kui bakterid on tildipirosiini suhtes tundlikud.
English: Special caution should be taken to avoid accidental self-injection, as laboratory studies in dogs showed cardiovascular effects after intramuscular injection of high doses of tildipirosin.
Estonian: Eriti hoolikalt tuleb vältida juhuslikku enesesüstimist, sest koertega korraldatud laboriuuringud näitasid tildipirosiini suurte annuste intramuskulaarse süsti järjel tekkivaid kardiovaskulaarseid nähte.
English: The withdrawal period for meat is nine days for pigs and 47 days for cattle.
Estonian: Keeluaeg on sigadel 9 päeva ja veistel 47 päeva.
English: The treatment studies looked at the improvement of the signs of respiratory disease and the prevention studies looked at the absence of signs of infection (fever, respiratory or behaviour abnormalities) in animals exposed to infection.
Estonian: Ravi uuringutes vaadeldi respiratoorse haiguse nähtude vähenemist ja ennetamise uuringutes nakkuse nähtude (palavik, hingamis- või käitumishäired) puudumist nakkusega kokku puutuvatel loomadel.
English: Other information about Zuprevo:
Estonian: Muu teave Zuprevo kohta
English: 229 pigs were treated with Zuprevo and 227 pigs were untreated controls that received saline.
Estonian: 229 siga raviti Zuprevoga, kontrollrühmas oli 227 siga, kellele süstiti füsioloogilist lahust.
English: The effectiveness of Zuprevo used for treatment and metaphylaxis of SRD in diseased pigs as well as in clinically healthy in-contact pigs was investigated in a field study in which an outbreak of SRD was confirmed with at least 30% of the pens showing clinical signs of SRD, including at least 10% of animals per pen within 1 day or 20% within 2 days or 30% within 3 days.
Estonian: Zuprevo efektiivsust sigade respiratoorse haiguse ravis ja metafülaktikas nii haigestunud kui ka kliiniliselt tervetel, kuid haigete loomadega kokku puutunud sigadel uuriti väliuuringus, milles SRD olemasolu kinnitati vähemalt 30% SRD sümptomitega sigadel, sh ühe lauda kohta vähemalt 10% ühe päeva jooksul või 20% kahe päeva jooksul või 30% kolme päeva jooksul.
English: The CVMP concluded that the benefits of Zuprevo outweigh the risks for the approved indications and recommended that Zuprevo be given a marketing authorisation.
Estonian: Veterinaarravimite komitee järeldas, et Zuprevo kasulikkus kasutamisel heakskiidetud näidustustel on suurem kui sellega kaasnevad riskid, ja soovitas anda ravimi müügiloa.
English: Cattle may also experience pain at the time of injection.
Estonian: Veised võivad süstimise ajal tunda valu.
English: This summary was last updated in February 2015.
Estonian: Kokkuvõtte viimane uuendus: 02-2015.
English: In the field studies, the medicine was compared with other antibiotics used in these diseases (tulathromycin or florfenicol).
Estonian: Väliuuringutes võrreldi ravimit teiste nimetatud haiguste ravimiseks kasutatavate antibiootikumidega (tulatromütsiin ja florfenikool).
English: Zuprevo is an antibiotic that belongs to the group ‘macrolides'.
Estonian: Zuprevo on makroliidide rühma kuuluv antibiootikum.
English: The dose to use is calculated according to the animal's weight.
Estonian: Kasutatav annus arvutatakse looma kehamassi alusel.
English: What is Zuprevo?
Estonian: Mis on Zuprevo?
English: Zuprevo is given as a single injection, into muscle for pigs, and under the skin for cattle.
Estonian: Zuprevot manustatakse ühekordse süstina sigadele lihasesse ning veistele naha alla.
English: The swelling can last for up to three days in pigs, and one to two weeks in cattle.
Estonian: Turse võib püsida sigadel kuni 3 päeva ja veistel 1-2 nädalat.
English: When using the antibiotic Zuprevo, it is essential to closely follow the instructions in the package leaflet to minimise the development of antibiotic resistance.
Estonian: Antibiootikumi (x) kasutamisel tuleb antibiootikumiresistentsuse arengu minimeerimiseks kindlasti hoolikalt järgida pakendi infolehe juhiseid.
English: The benefit/risk balance may be found in the scientific discussion module of this EPAR.
Estonian: Zuprevo kasulikkuse ja riski suhe on käesoleva Euroopa avaliku hindamisaruande teadusliku arutelu jaotises.
English: medical advice should be sought immediately and the package leaflet or the label should be shown to the doctor.
Estonian: Juhusliku enesesüstimise korral tuleb pöörduda kohe arsti poole ja näidata ravimi pakendi infolehte või etiketti.
English: The withdrawal period is the time allowed after administration of the medicine before the animal can be slaughtered and the meat or milk used for human consumption.
Estonian: Keeluaeg on ravimi manustamisest arvestatav aeg, mille jooksul ei tohi looma tappa ega tema liha ega piima tarvitada toiduks.
English: Zuprevo should not be used in animals that are hypersensitive (allergic) to macrolide antibiotics or to any of the excipients.
Estonian: Zuprevot ei tohi kasutada loomadel, kes on makroliidantibiootikumide või ravimi mis tahes abiainete suhtes ülitundlikud (allergilised).
English: It works by blocking the bacterias' ribosomes, the parts of the cell where proteins are produced, and blocking the growth of bacteria.
Estonian: See blokeerib bakterite ribosoomid ehk rakuosad, kus toimub valgusüntees; ribosoomide blokeerimine pärsib bakterite kasvu.
English: Zuprevo is an antibiotic used in pigs to treat swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica and Haemophilus parasuis.
Estonian: Zuprevo on antibiootikum, mida kasutatakse bakterite Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica ja Haemophilus parasuis põhjustatud sigade respiratoorse haiguse (SRD) raviks.
English: During severe outbreaks of SRD Zuprevo can also be used metaphylactically which means to treat at the same time both diseased pigs and those clincially healthy pigs in close contact with them, to prevent them from developing clinical signs and to prevent further spread of the disease.
Estonian: SRD raskete puhangute ajal tohib Zuprevot kasutada ka metafülaktiliselt, st ravida samal ajal nii haigestunud kui ka kliiniliselt terveid, ent haigete loomadega kokku puutunud sigu, et ennetada neil kliinilisi sümptomeid ja haiguse edasist levikut.
English: What is the risk associated with Zuprevo?
Estonian: Mis riskid Zuprevoga kaasnevad?
English: Why has Zuprevo been approved?
Estonian: Miks Zuprevo heaks kiideti?
English: Animals treated with Zuprevo may develop a swelling at the site of the injection, especially when larger volumes are used, therefore each injection is limited to a maximum volume (5 ml in pigs and 10 ml in cattle).
Estonian: Zuprevoga ravitud loomadel võib eelkõige suuremate mahtude kasutamise korral tekkida süstekoha turse, mistõttu on iga süsti suurim maht sigadel 5 ml ja veistel 10 ml.
English: How does Zuprevo work?
Estonian: Kuidas Zuprevo toimib?
English: What is Zuprevo used for?
Estonian: Milleks Zuprevot kasutatakse?
English: When used to prevent BRD, the presence of the disease in the herd should be confirmed before use.
Estonian: Zuprevo kasutamisel veiste respiratoorsete haiguse ennetamiseks peab eelnevalt tuvastama haiguse olemasolu karjas.
English: When Zuprevo was used for treatment and metaphylaxis of SRD in diseased and clinically healthy incontact pigs approximately 86% of the healthy pigs remained free of clinical signs of disease compared with approximately 65% of pigs in the untreated control group.
Estonian: Terveid sigu, kellel Zuprevo kasutamisel SRDga sigade ravis ja haigete loomadega kokku puutunud tervete loomade metafülaktikas ei tekkinud kliinilisi sümptomeid, oli ligikaudu 86% ja ravita kontrollrühmas 65%.
English: The studies in SRD included pigs between three and 21 weeks of age, and those in BRD included cattle between one and 24 months of age.
Estonian: Sigade respiratoorse haiguse uuringud toimusid 3-21-nädalastel sigadel ja veiste respiratoorse haiguse uuringud 1-24-kuistel veistel.
English: What benefit has Zuprevo shown during the studies?
Estonian: Milles seisneb uuringute põhjal Zuprevo kasulikkus?
English: Zuprevo is used in cattle to treat and prevent bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni.
Estonian: Veistel kasutatakse Zuprevot bakterite Mannheimia haemolytica, Pasteurella multocida ja Histophilus somni põhjustatud veiste respiratoorse haiguse (BRD) ennetamiseks ja raviks.
English: Tildipirosin may cause sensitisation by skin contact.
Estonian: Nahale sattumisel võib tildipirosiin põhjustada nahaärritust.
English: The effectiveness of Zuprevo was shown to be comparable to that of tulathromycin or florfenicol in the treatment of SRD, and in the treatment and prevention of BRD.
Estonian: Sigade respiratoorse haiguse ravis ning veiste respiratoorse haiguse ravis ja ennetamisel oli Zuprevo efektiivsus võrreldav tulatromütsiini ja florfenikooli efektiivsusega.
English: Laboratory as well as field studies were conducted to look at the use of Zuprevo in both the treatment and metaphylaxis of SRD and the treatment and prevention of BRD.
Estonian: Zuprevo kasutamist sigade respiratoorse haiguse ravis ja metafülaktikas ning veiste respiratoorse haiguse ravis ja ennetamisel uuriti labori- ja väliuuringutes.
English: 1 Quarter 2026
Estonian: I kvartal 2026
English: Date of first authorisation: 27 May 2015
Estonian: Müügiloa esmase väljastamise kuupäev: 27. mai 2015
English: Patients were treated for up to 3 years.
Estonian: Patsiente raviti kuni 3 aasta jooksul.
English: Smoking and alcohol
Estonian: Suitsetamine ja alkohol
English: Your doctor will be able to decide what is suitable for you.
Estonian: Teie arst otsustab, mis teile sobib.
English: Not known: frequency cannot be estimated from the available data
Estonian: Teadmata: sagedust ei saa hinnata olemasolevate andmete alusel
English: Drinking enough water
Estonian: Piisav vee joomine
English: • allergic reactions (see above)
Estonian: • allergilised reaktsioonid (vt eespool)
English: The lower dose is taken 8 hours later.
Estonian: Väiksem annus võetakse 8 tundi hiljem.
English: 1101 CT, Amsterdam Netherlands
Estonian: 1101 CT, Amsterdam Holland
English: Your medicine is supplied in the following pack sizes:
Estonian: Teie ravimit turustatakse järgmise suurusega pakendites:
English: In particular this applies to patients with inadequately controlled type II diabetes.
Estonian: See kehtib eelkõige patsientide kohta, kellel on ebapiisavalt ravile alluv II tüüpi diabeet.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Estonian: Teatage oma arstile või apteekrile, kui te võtate või olete hiljuti võtnud mis tahes muid ravimeid, kaasa arvatud ilma retseptita ostetud ravimeid.
English: Patients have to be carefully monitored during treatment.
Estonian: Patsiente tuleb ravi ajal hoolikalt jälgida.
English: The advice of a hepatologist is recommended.
Estonian: Soovitatakse pidada nõu hepatoloogiga.
English: The absolute bioavailability of tolvaptan is about 56 %.
Estonian: Tolvaptaani absoluutne biosaadavus on ligikaudu 56 %.
English: • Advice if such symptoms occur
Estonian: • nõuanded nende sümptomite tekkimise puhuks
English: • if you cannot drink enough water (see “drinking enough water” below) or if you have to restrict your fluid intake.
Estonian: • kui te ei saa juua piisavalt vett (vt allpool “Piisav vee joomine”) või peate oma vedelikutarbimist piirama;
English: Due to the increased urine production it is also important that you always have access to a toilet.
Estonian: Suurenenud uriinierituse tõttu on ka tähtis olla alati tualeti lähedal.
English: Jinarc has not been studied in children and adolescents (under age 18) and its use is therefore not recommended in these age groups.
Estonian: Jinarci kasutamist lastel ja noorukitel (alla 18 aasta vanuses) ei ole uuritud ja seetõttu ei soovitata seda neil vanuserühmadel kasutada.
English: Liver transplantation was necessary.
Estonian: Vajalik oli maksasiirdamine.
English: If you notice any of the following side effects, you may need urgent medical attention.
Estonian: Kui märkate järgmisi kõrvaltoimeid, võite vajada kiiresti meditsiinilist abi.
English: Remember to take the medicine pack with you so that it is clear what you have taken.
Estonian: Pidage meeles võtta ravimi pakend kaasa, et oleks selge, millist ravimit olete võtnud.
English: During long-term treatment electrolytes have to be monitored at least every three months.
Estonian: Pikaajalise ravi korral tuleb elektrolüütide tasemeid jälgida vähemalt iga kolme kuu järel.
English: • if you have diabetes.
Estonian: • kui teil on diabeet;
English: Access to water
Estonian: Vee kättesaadavus
English: Before bedtime you must drink 1 or 2 glasses of water even if you do not feel thirsty and you must also drink water after you urinating at night.
Estonian: Enne magamaminekut peate jooma 1 või 2 klaasi vett, isegi kui te ei tunne janu, ja peate jooma vett ka pärast öösel urineerimist.
English: Consequently, the frequency of these adverse events is qualified as "not known".
Estonian: Seega liigitatakse nende kõrvaltoimete sagedus kui „teadmata“.
English: If you forget to take your medicine you should take the dose as soon as you remember on the same day.
Estonian: Kui te unustate ravimit võtta, peate võtma annuse samal päeval, niipea kui see meelde tuleb.
English: The most frequent adverse reactions are related to water loss.
Estonian: Kõige sagedamad kõrvaltoimed on seotud veekaotusega.
English: If you do not take your tablets on one day, take your normal dose on the next day.
Estonian: Kui jätate oma tabletid ühel päeval võtmata, võtke järgmisel päeval oma tavaline annus.
English: You should always take the highest tolerable dose combination prescribed by your doctor.
Estonian: Peate alati võtma suurimat talutavat annusekombinatsiooni, mille teie arst on määranud.
English: If you take the higher dose very late in the day you may have to go to the toilet at night more frequently.
Estonian: Kui võtate suurema annuse päeva lõpu poole, võib osutuda vajalikuks käia öösel sagedamini tualetis.
English: Fluid and electrolyte status must be monitored in all patients.
Estonian: Vedelike ja elektrolüütide tasakaalu tuleb jälgida kõikidel patsientidel.
English: • thirst (requiring excessive drinking of water)
Estonian: • janu (vajadus juua ülemäära vett)
English: The second daily dose can be taken with or without food.
Estonian: Päeva teise annuse võib manustada koos toiduga või ilma.
English: • Patterns of medicinal product utilisation, especially with regards to off label use and use in patients over 50 years old
Estonian: • ravimi kasutustavade kohta, eelkõige müügiloata kasutamise ja üle 50 aasta vanustel patsientidel kasutamise kohta
English: 30 mg (further reduction to 15 mg if 30 mg are not well tolerated)
Estonian: 30 mg (vähendada täiendavalt tasemeni 15 mg, kui 30 mg ei ole hästi talutav)
English: The safety and efficacy of tolvaptan in children and adolescents has not yet been established.
Estonian: Tolvaptaani ohutus ja efektiivsus lastel ja noorukitel ei ole veel tõestatud.
English: Very common: may affect more than 1 in 10 people
Estonian: Väga sage: võib esineda rohkem kui 1 inimesel 10st
English: Therefore, please inform your doctor immediately if you have signs that could indicate potential liver problems such as:
Estonian: Seetõttu teatage kohe oma arstile, kui teil tekivad võimalikele maksahäiretele viitavad nähud, näiteks:
English: If this happens to you, do not drive or use any tools or machines.
Estonian: Sel juhul ärge juhtige autot ega käsitsege tööriistu ega masinaid.
English: During treatment with Jinarc, your doctor will arrange monthly blood tests to check for changes in your liver function.
Estonian: Ravi ajal Jinarciga määrab arst teile iga kuu vereproove, et kontrollida muutusi teie maksa talitluses.
English: Following an additional 2 years of tolvaptan treatment, resulting in a total of 5 years on tolvaptan therapy no new safety signals were identified.
Estonian: Pärast täiendavat 2-aastast ravi tolvaptaaniga, mis andis kogu tolvaptaaniga ravi kestuseks 5 aastat, ei tuvastatud ühtegi uut ohutusega seotud signaali.
English: The frequency of adverse reactions reported during post-marketing use cannot be determined as they are derived from spontaneous reports.
Estonian: Turuletulekujärgselt teatatud kõrvaltoimete sagedust ei saa hinnata, kuna need põhinevad spontaansetel teadetel.
English: Jinarc with food and drink Do not drink grapefruit juice when taking Jinarc.
Estonian: Jinarc koos toidu ja joogiga Ärge jooge Jinarci võtmise ajal greibimahla.
English: Information in braille:
Estonian: Teave braille' kirjas:
English: This type of reaction occurred after the first administration of tolvaptan.
Estonian: Seda tüüpi reaktsioon tekkis pärast tolvaptaani esmakordset manustamist.
English: Urinary output must be secured.
Estonian: Tuleb tagada uriini väljutamine.
English: Since hypersensitivity is a contraindication (see section 4.3) treatment must never be restarted after an anaphylactic reaction or other serious allergic reactions.
Estonian: Kuna ülitundlikkus on vastunäidustus (vt lõik 4.3), ei tohi ravi pärast anafülaktilise reaktsiooni või muude tõsiste allergiliste reaktsioonide tekkimist enam kunagi uuesti alustada.
English: Appropriate replacement of water and/or electrolytes must continue until aquaresis abates.
Estonian: Vee ja/või elektrolüütide sobivat asendamist tuleb jätkata kuni veekaotuse leevendumiseni.
English: ‘Tolvaptan (n = 961) and placebo (n = 484) groups were well matched in terms of gender with an average age of 39 years.
Estonian: Tolvaptaani (n = 961) ja platseebo (n = 484) rühmad olid sooliselt hästi vastavuses ja keskmise vanusega 39 aastat.
English: The design was used to minimize the impact of early discontinuation and missing data on trial endpoints.
Estonian: Disaini kasutati, et vähendada varajast katkestamist ja sellest tulenevaid puuduvaid andmeid uuringu tulemusnäitajates.
English: • increased need to urinate, to urinate at night, or to urinate more frequently
Estonian: • suurenenud urineerimisvajadus, öine urineerimisvajadus või sagedam urineerimisvajadus
English: Fourteen metabolites have been identified in plasma, urine and faeces; all but one were also metabolised by CYP3A.
Estonian: Plasmast, uriinist ja väljaheitest on leitud 14 metaboliiti; neid kõiki, välja arvatud ühte, metaboliseeris ka CYP3A.
English: Studies in rats have shown excretion of tolvaptan in milk.
Estonian: Uuringud rottidega on näidanud tolvaptaani eritumist piima.
English: Swallow the tablets without chewing, with a glass of water.
Estonian: Neelake tabletid alla ilma närimata, koos klaasitäie veega.
English: Prescribing physicians must comply fully with the safety measures required below.
Estonian: Ravimi väljakirjutamisel peab arst täielikult järgima alltoodud nõutavaid ohutusmeetmeid.
English: It is therefore important that you have access to water and that you are able to drink sufficient amounts when you feel thirsty.
Estonian: Seetõttu on tähtis, et teile oleks vesi kättesaadav ning et janu tundes saaksite juua piisavalt.
English: • if you have difficulties urinating or have an enlarged prostate.
Estonian: • kui teil on raskusi urineerimisega või suurenenud eesnääre;
English: Prior to launch of Jinarc in each Member State the Marketing Authorisation Holder must agree the content and format of the educational programme, including communication media and distribution modalities with each National Competent Authority.
Estonian: Enne Jinarci turule toomist igas liikmesriigis peab müügiloa hoidja kooskõlastama riigi pädeva ametiasutusega teavitusprogrammi sisu ja vormi, sealhulgas teavitamiskanalid ja levitamisviisid.
English: Almac Pharma Service (Ireland) Limited Finnabair Industrial Estate, Dundalk, Co. Louth - A91 P9KD Ireland
Estonian: Almac Pharma Service (Ireland) Limited Finnabair Industrial Estate, Dundalk, Co. Louth - A91 P9KD Iirimaa
English: • if you suffer from too high or too low blood sodium.
Estonian: • kui teil on liiga kõrge või liiga madal vere naatriumisisaldus;
English: • Hypernatraemia
Estonian: • Hüpernatreemia.
English: Patients taking moderate or strong CYP3A inhibitors must be managed cautiously, in particular if the inhibitors are taken more frequently than once a day.
Estonian: Mõõdukaid või tugevaid CYP3A inhibiitoreid kasutavate patsientide ravimisel tuleb olla ettevaatlik, eriti kui inhibiitoreid võetakse sagedamini kui üks kord ööpäevas.
English: The educational programme is aimed at ensuring awareness about the potential risk of hepatotoxicity and providing guidance on how to manage this risk and the importance of pregnancy prevention prior to the initiation and during the treatment with Jinarc.
Estonian: Teavitusprogrammi eesmärk on tagada teadlikkus potentsiaalsest hepatotoksilisuse riskist ja anda juhiseid selle riski vähendamiseks ning rasedusest hoidumise tähtsusest enne ravi alustamist Jinarciga ja ravi ajal.
English: Only the oxobutyric acid metabolite is present at greater than 10 % of total plasma radioactivity; all others are present at lower concentrations than tolvaptan.
Estonian: Ainult oksovõihappe metaboliit hõlmas rohkem kui 10 % kogu plasma radioaktiivsusest; kõiki teisi esines tolvaptaanist väiksemates kontsentratsioonides.
English: Women of childbearing age must use reliable contraceptive measures during use of this medicine.
Estonian: Fertiilses eas naised peavad selle ravimi kasutamise ajal kasutama usaldusväärseid rasestumisvastaseid vahendeid.
English: If you have taken more tablets than your prescribed dose, drink plenty of water and contact your doctor or your local hospital immediately.
Estonian: Kui olete võtnud teile määratud annusest rohkem tablette, jooge palju vett ja võtke kohe ühendust oma arstiga või pöörduge kohalikku haiglasse.
English: Common: may affect up to 1 in 10 people
Estonian: Sage: võib esineda kuni 1 inimesel 10st
English: If you stop taking Jinarc your kidney cysts may grow as fast as they did before you started treatment with Jinarc.
Estonian: Kui te lõpetate Jinarci võtmise, võivad teie neerutsüstid kasvada sama kiiresti kui enne ravi alustamist Jinarciga.
English: Patients have to be instructed to drink water or other aqueous fluids at the first sign of thirst in order to avoid excessive thirst or dehydration.
Estonian: Patsientidele tuleb anda juhis juua vett või muid vett sisaldavaid vedelikke janu esimeste märkide korral, et vältida liigse janu või dehüdratsiooni tekkimist.