FrancophonIA/ELRC3.0 huggingface dataset:
English: For patients who were randomized to quetiapine, the mean weight gain during the open label period was 2.56 kg, and by week 48 of the randomized period, the mean weight gain was 3.22 kg, compared to open label baseline.
Slovenian: randomiziranih na kvetiapin, je bilo povprečno povečanje telesne mase med odprtim obdobjem 2,56 kg, do 48. tedna randomiziranega obdobja pa je bilo povprečno povečanje telesne mase 3,22 kg v primerjavi z izhodiščem odprtega obdobja.
English: Concomitant administration of cytochrome P450 3A4 inhibitors, such as HIV-protease inhibitors, azoleantifungal agents, erythromycin, clarithromycin and nefazodone, is contraindicated.
Slovenian: Kontradicirana je sočasna uporaba z zaviralci citokroma P450 3A4, kot so zaviralci proteaz HIV, protiglivična zdravila iz skupine azolov, eritromicin, klaritromicin in nefazodon (glejte tudi poglavje
English: If it is almost time to take the next dose, wait until then.
Slovenian: Če ste pozabili vzeti odmerek, ga vzemite, čim se spomnite, razen, če je že skoraj čas za naslednjo tableto, v tem primeru počakajte do takrat.
English: In a clinical trial to evaluate the cataractogenic potential of Seroquel (200-800 mg/day) versus risperidone (2-8 mg/day) in patients with schizophrenia or schizoaffective disorder, the percentage of patients with increased lens opacity grade was not higher in Seroquel (4%) compared with risperidone (10%), for patients with at least 21 months of exposure.
Slovenian: Katarakte/zamotnitev očesne leče V kliničnih preskušanjih, kjer so ocenjevali vpliv zdravila Seroquel (200-800 mg/dan) na nastanek katarakte, v primerjavi z risperidonom (2-8 mg/dan) pri bolnikih s shizofrenijo ali shizofrenimi motnjami, odstotek bolnikov s povečano stopnjo motnosti očesne leče, pri zdravilu Seroquel ni bil višji (4%) v primerjavi z risperidonom (10 %) pri bolnikih, ki so zdravilo prejemali vsaj 21 mesecev.
English: • You have diabetes or have a risk of getting diabetes.
Slovenian: • ste kdaj doživeli napad krčev (konvulzije), • imate sladkorno bolezen ali pa povečano tveganje za nastanek sladkorne bolezni.
English: • If you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel (see section 6: Further information)
Slovenian: • če ste alergični na (preobčutljivi za) kvetiapin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: 20 tablets
Slovenian: 20 tablet
English: Seroquel XR dose can be adjusted depending on clinical response and tolerability of the individual patient within the dose range of 300 mg to 800 mg/day.
Slovenian: Odmerek zdravila Seroquel SR je mogoče prilagoditi glede na klinični odziv in prenašanje posameznega bolnika v razponu od 300 do 800 mg/dan.
English: No data is available about the incidence of seizures in patients with a history of seizure disorder.
Slovenian: Podatkov o incidenci konvulzij pri bolnikih z anamnezo konvulzivne motnje ni.
English: • Yellowing of the skin and eyes (jaundice).
Slovenian: • porumenelost kože in očesnih beločnic (zlatenica),
English: In post-marketing, QT prolongation was reported with quetiapine at the therapeutic doses (see Section 4.8) and in overdose (see Section 4.9).
Slovenian: V obdobju po prihodu zdravila na trg so ugotovili podaljšanje QT pri terapevtskih odmerkih (glejte poglavje 4.8) in pri prevelikem odmerjanju (glejte poglavje 4.9).
English: Treatment with quetiapine should be reassessed in patients with suspected cardiomyopathy or myocarditis.
Slovenian: Pri bolnikih s sumom na kardiomiopatijo ali miokarditis je treba zdravljenje s kvetiapinom ponovno pretehtati.
English: Quetiapine is well absorbed following oral administration.
Slovenian: Kvetiapin se po peroralni uporabi dobro absorbira.
English: (7) An increase in the rate of dysphagia with quetiapine vs. placebo was only observed in the clinical trials in bipolar depression.
Slovenian: (7) Pogostejše pojavljanje disfagije med uporabo kvetiapina v primerjavi s placebom so zabeležili samo v kliničnih preskušanjih pri bipolarni depresiji.
English: Not known (frequency cannot be estimated from the available data)
Slovenian: Neznana pogostnost: pogostnosti iz razpoložljivih podatkov ni mogoče oceniti • kožni izpuščaj z nepravilnimi rdečimi pikami po koži (multiformni eritem),
English: If you are having a urine drug screen, taking Seroquel may cause positive results for methadone or certain drugs for depression called tricyclic antidepressants (TCAs) when some test methods are used, even though you may not be taking methadone or TCAs.
Slovenian: Če vam bodo pregledali urin za določanje vsebnosti zdravil, lahko jemanje zdravila Seroquel povzroči lažno pozitivne rezultate za metadon ali zdravila za zdravljenje depresije imenovana triciklični antidepresivi.
English: (9) The following withdrawal symptoms have been observed most frequently in acute placebo-controlled, monotherapy clinical trials, which evaluated discontinuation symptoms: insomnia, nausea, headache, diarrhoea, vomiting,
Slovenian: (9) V akutnem, s placebom kontroliranem preskušanju (monoterapija), kateri je ocenjeval odtegnitvene simptome, so opazili naslednje odtegnitvene simptome: nespečnost, slabost, glavobol, diarejo,
English: • Do not split, chew or crush the tablets.
Slovenian: • Tablet s podaljšanim sproščanjem ne lomite, ne žvečite in ne drobite.
English: In a 6-week, randomised, study of lithium and SEROQUEL XR versus placebo and SEROQUEL XR in adult patients with acute mania, the difference in YMRS mean improvement between the lithium add-on group and the placebo add-on group was 2.8 points and the difference in % responders (defined as 50% improvement from baseline on the YMRS) was 11% (79% in the lithium add-on group vs. 68% in the placebo add-on group).
Slovenian: Seroquel SR, pri odraslih bolnikih z akutno manijo, je bila razlika v povprečnem izboljšanju po lestvici YMRS med skupino z dodatkom litija in skupino z dodatkom placeba 2,8 točke, razlika v odstotku odzivnih bolnikov (odzivnost je bila opredeljena kot 50 % izboljšanje v primerjavi z izhodiščnim YMRS) pa je bila 11 % (79 % v skupini z dodatkom litija in 68 % v skupini z dodatkom placeba).
English: With respect to weight gain, when adjusting for normal growth over the longer term, an increase of at least 0.5 standard deviation from baseline in Body Mass Index (BMI) was used as a measure of a clinically significant change; 18.3% of patients who were treated with quetiapine for at least 26 weeks met this criterion.
Slovenian: Kar zadeva povečanje telesne mase, je bila v primeru korekcije za normalno rast v daljšem obdobju kot mera klinično pomembne spremembe uporabljeno povečanje za vsaj 0,5 standardnega odklona od izhodiščnega indeksa telesne mase (ITM);
English: somnolence headache, Extrapyramidal symptoms1, 21
Slovenian: zaspanost glavobol, ekstrapiramidn i simptomi1, 21
English: In controlled clinical trials there was no difference in the incidence of seizures in patients treated with quetiapine or placebo.
Slovenian: V kontroliranih kliničnih preskušanjih se incidenca konvulzij med prejemniki kvetiapina in placeba ni razlikovala.
English: • Take your tablets without food (at least one hour before a meal or at bedtime, your doctor will tell you when.
Slovenian: • Ne jemljite tablet s podaljšanim sproščanjem sočasno s hrano (vzemite jih vsaj eno uro pred obrokom ali pred spanjem.
English: In shorter-term placebo controlled clinical studies of patients with major depressive episodes in bipolar disorder an increased risk of suicide-related events was observed in young adult patients (younger than 25 years of age) who were treated with quetiapine as compared to those treated with placebo (3.0% vs. 0%, respectively).
Slovenian: V kratkotrajnih s placebom kontroliranih kliničnih študijah bolnikov s hudimi obdobji depresije pri bipolarni motnji so ugotovili večje tveganje s samomorom povezanih dogodkov pri mladih odraslih bolnikih (mlajših od 25 let), ki so prejemali kvetiapin (3,0 %), kot pri tistih, ki so prejemali placebo
English: Quetiapine was administered twice-daily totalling 400 mg to 800 mg a day as combination therapy to lithium or valproate.
Slovenian: Kvetiapin so uporabljali dvakrat na dan v skupnem odmerku od 400 do 800 mg na dan, kot kombinirano terapijo z litijem ali valproatom.
English: What Seroquel XR is and what it is used for What you need to know before you take Seroquel XR How to take Seroquel XR
Slovenian: Kaj je zdravilo Seroquel SR in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Seroquel SR Kako jemati zdravilo Seroquel SR
English: A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel XR to be stopped and/or treatment to be given.
Slovenian: • zvišano telesno temperaturo, gripi podobne simptome, vneto žrelo ali kakšno drugo okužbo, kajti to je lahko posledica zelo majhnega števila belih krvnih celic; morda boste morali nehati jemati zdravilo Seroquel SR in/ali boste potrebovali zdravljenje.
English: Day 1
Slovenian: Preglednica 1
English: Drug withdrawal syndrome neonatal31
Slovenian: puerperija in perinatalnem obdobju neonatalni odtegnitveni sindrom31
English: A meta analysis of placebo controlled clinical trials of antidepressant drugs in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Slovenian: Metaanaliza s placebom nadzorovanih kliničnih preskušanj antidepresivov pri odraslih bolnikih s psihiatričnimi motnjami je pokazala, da pri bolnikih, mlajših od 25 let, pri uporabi antidepresivov obstaja večje tveganje za pojav samomorilnega vedenja kot pri uporabi placeba.
English: In vitro investigations established that CYP3A4 is the primary enzyme responsible for cytochrome P450 mediated metabolism of quetiapine.
Slovenian: Raziskave in vitro kažejo, da je CYP3A4 glavni encim, odgovoren za presnovo kvetiapina s citokromom P450.
English: QT prolongation 1,12
Slovenian: QT 1,12, 18
English: Do not take Seroquel XR if the above applies to you.
Slovenian: Ne jemljite zdravila Seroquel SR, če kaj od zgoraj naštetega velja za vas.
English: Do not take Seroquel if the above applies to you.
Slovenian: Ne jemljite zdravila Seroquel, če kaj od zgoraj naštetega velja za vas.
English: Orthostatic hypotension:
Slovenian: Ortostatska hipotenzija:
English: A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel to be stopped and/or treatment to be given.
Slovenian: • zvišano telesno temperaturo, gripi podobne simptome, vneto žrelo ali kakšno drugo okužbo, kajti to je lahko posledica zelo majhnega števila belih krvnih celic; morda boste morali nehati jemati zdravilo Seroquel in/ali boste potrebovali zdravljenje.
English: Quetiapine treatment was associated with dose-related decreases in thyroid hormone levels.
Slovenian: Zdravljenje s kvetiapinom je bilo povezano z odmerkom, povezanim znižanjem koncentracije ščitničnih hormonov.
English: QT Prolongation
Slovenian: Podaljšanje intervala QT
English: • Epilepsy medicines (like phenytoin or carbamazepine).
Slovenian: • zdravila za zdravljenje epilepsije (kot sta fenitoin ali karbamazepin), • zdravila za zdravljenje visokega krvnega tlaka,
English: If you forget to take a dose of Seroquel
Slovenian: Če ste pozabili vzeti zdravilo Seroquel
English: The dose may be adjusted depending on clinical response and tolerability of the individual patient, within the range of 300 to 800 mg/day administered twice daily.
Slovenian: Odmerek je mogoče prilagoditi glede na klinični odziv in prenašanje posameznega bolnika v razponu od 300 do 800 mg/dan dvakrat dnevno.
English: • Difficulty in passing urine.
Slovenian: • težave pri požiranju,
English: Withdrawal (dis continuation) symptoms 1,9
Slovenian: Splošne težave in spremembe na mestu aplikacije odtegnitveni (prekinitveni) simptomi 1,9
English: Read all of this leaflet carefully before you start taking this medicine.
Slovenian: Pred začetkom jemanja zdravila natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
English: o For the treatment of moderate to severe manic episodes in bipolar disorder o For the treatment of major depressive episodes in bipolar disorder o For the prevention of recurrence of manic or depressed episodes in patients with bipolar disorder who previously responded to quetiapine treatment.
Slovenian: o za zdravljenje zmernih do hudih maničnih epizod pri bipolarni motnji o za zdravljenje velikih depresivnih epizod pri bipolarni motnji o za preprečevanje ponavljanja epizod manije ali depresije pri bolnikih z bipolarno motnjo,
English: The pharmacokinetics of lithium were not altered when co-administered with quetiapine.
Slovenian: Farmakokinetika litija se pri sočasnem jemanju s kvetiapinom ne spremeni.
English: (3) Asymptomatic elevations (shift from normal to > 3X ULN at any time) in serum transaminase (ALT, AST) or gamma-GT-levels have been observed in some patients administered quetiapine.
Slovenian: (3) Pri nekaterih bolnikih, ki so dobivali kvetiapin, so opazili asimptomatsko zvišanje (premik od običajnega do > 3X ULN kadarkoli) serumskih transaminaz (ALT, AST) ali gama-GT.
English: Seroquel was administered twice-daily totalling 400 mg to 800 mg a day as combination therapy to lithium or valproate.
Slovenian: Zdravilo Seroquel so uporabljali dvakrat na dan v skupnem odmerku od 400 do 800 mg na dan, kot kombinirano terapijo z litijem ali valproatom.
English: Switching from Seroquel immediate-release tablets:
Slovenian: Prehod z zdravila Seroquel filmsko obložene tablete:
English: The mean plasma clearance of quetiapine was reduced by 30% to 50% in elderly patients when compared to younger patients.
Slovenian: Povprečni plazemski očistek kvetiapina je bil pri starejših bolnikih za 30 do 50 % manjši kot pri mlajših.
English: 6 x 25 mg film-coated tablets 2 x 100 mg film-coated tablets
Slovenian: 6 x 25 mg filmsko obloženih tablet 2 x 100 mg filmsko obloženih tablet
English: What Seroquel XR looks like and contents of the pack
Slovenian: Izgled zdravila Seroquel SR in vsebina pakiranja
English: The estimated risks of relapse after 6 months treatments was 14.3% for the Seroquel XR treatment group compared to 68.2% for placebo.
Slovenian: Ocenjeno tveganje recidiva po 6 mesecih zdravljenja je bilo 14,3 % v skupini, ki je dobivala zdravilo Seroquel SR, in
English: Increases in triglycerides, LDL and total cholesterol, and decreases in HDL cholesterol have been observed in clinical trials with quetiapine (see section 4.8).
Slovenian: V kliničnih preskušanjih s kvetiapinom so opazili porast trigliceridov, LDL in celokupnega holesterola ter znižanje HDL (glejte poglavje 4.8).
English: (10) Triglycerides ≥200 mg/dL (≥2.258 mmol/L) (patients ≥18 years of age) or ≥150 mg/dL (≥1.694 mmol/L) (patients
Slovenian: (10) Trigliceridi ≥ 200 mg/dl (≥ 2,258 mmol/l) (bolniki, stari ≥ 18 let) ali ≥ 150 mg/dl (≥ 1,694
English: • Constipation, upset stomach (indigestion).
Slovenian: • zaprtost, težave z želodcem (slaba prebava),
English: Shifts in eosinophils are defined as >1x 10^9 cells/L at any time.
Slovenian: Premiki so opredeljeni kot zvišanje števila eozinofilcev kadarkoli > 1 x 10
English: 6 blisters of 10 tablets 12 blisters of 5 tablets
Slovenian: 6 pretisnih omotov po 10 tablet 12 pretisnih omotov po 5 tablet
English: In all short-term placebo-controlled monotherapy trials in patients with a baseline neutrophil count ≥1.5 X 109/L, the incidence of at least one occurrence of a shift to neutrophil count <1.5 X 109/L, was 1.9% in patients treated with quetiapine compared to 1.5% in placebo-treated patients.
Slovenian: V vseh kratkotrajnih preskušanjih monoterapije, kontroliranih s placebom, pri bolnikih z izhodiščnim številom nevtrofilcev ≥ 1,5 x 109/l je bila incidenca vsaj ene spremembe števila nevtrofilcev na < 1,5 x 109/l pri bolnikih, zdravljenih s kvetiapinom 1,9 % in 1,5 % pri bolnikih, ki so dobivali placebo.
English: Interactions See also section 4.5
Slovenian: Medsebojno delovanje Glejte tudi poglavje 4.5.
English: In both bipolar depression and MDD, the incidence of the individual adverse events (eg, akathisia, extrapyramidal disorder, tremor, dyskinesia, dystonia, restlessness, muscle contractions involuntary, psychomotor hyperactivity and muscle rigidity) did not exceed 4% in any treatment group.
Slovenian: ekstrapiramidne motnje, tremorja, diskinezije, distonije, nemira, nehotnih mišičnih kontrakcij, psihomotorične hiperaktivnosti in mišične togosti) v nobeni terapevtski skupini presegla 4 %.
English: How to take Seroquel
Slovenian: Kako jemati zdravilo Seroquel
English: Very Common Common
Slovenian: Zelo pogosti Pogosti
English: Patients with hepatic impairment should be started on 50 mg/day.
Slovenian: Pri bolnikih z okvaro jeter je treba zdravljenje začeti s 50 mg/dan.
English: 6 x 25 mg film-coated tablets 3 x 100 mg film-coated tablets 1 x 200 mg film-coated tablets
Slovenian: 6 x 25 mg filmsko obloženih tablet 3 x 100 mg filmsko obloženih tablet 1 x 200 mg filmsko obloženih tablet
English: • A slower than normal heart rate which may occur when starting treatment and which may be associated with low blood pressure and fainting.
Slovenian: • nenormalno počasno bitje srca; pojavi se lahko na začetku zdravljenja in ga lahko spremljata nizek krvni tlak in omedlevica, • težave pri odvajanju urina,
English: This includes fatal reports in patients who are at higher risk of intestinal obstruction, including those that are receiving multiple concomitant medications that decrease intestinal motility and/or may not report symptoms of constipation.
Slovenian: To vključuje smrtne primere pri bolnikih z večjim tveganjem za zaporo črevesa, vključno s tistimi, ki sočasno prejemajo več zdravil, ki zmanjšujejo motiliteto črevesa; ti bolniki lahko navajajo simptome zaprtosti ali pa ne. Bolnike z zaporo črevesa/ileusom je treba obravnavati s skrbnim nadzorom in nujnim zdravljenjem.
English: <[To be completed nationally]>
Slovenian: <izpolni država članica>
English: If you take more Seroquel XR than prescribed by your doctor, you may feel sleepy, feel dizzy and experience abnormal heart beats.
Slovenian: Če ste vzeli večji odmerek zdravila Seroquel SR, kot vam ga je predpisal vaš zdravnik, boste lahko zaspani, omotični ali se vam bo pojavilo nepravilno bitje srca.
English: In 4 clinical trials with a duration of 8 weeks in patients with moderate to severe depressive episodes in bipolar I or bipolar II disorder, Seroquel IR 300 mg and 600 mg was significantly superior to placebo treated patients for the relevant outcome measures: mean improvement on the MADRS and for response defined as at least a 50% improvement in MADRS total score from baseline.
Slovenian: V štirih 8-tedenskih kliničnih preskušanjih pri bolnikih z zmernimi do hudimi depresivnimi epizodami v okviru bipolarne motnje I ali II, je bilo zdravilo Seroquel v odmerkih 300 mg in 600 mg statistično značilno boljše od placeba pri relevantnih merilih izida: povprečnem izboljšanju MADRS in odzivu, opredeljenem kot izboljšanje celotnega seštevka MADRS za vsaj 50 % v primerjavi z izhodiščem.
English: Seroquel XR contains lactose which is a type of sugar.
Slovenian: Zdravilo Seroquel SR vsebuje laktozo, ki je vrsta sladkorja.
English: Patients with known hepatic impairment should be started with 25 mg/day.
Slovenian: Pri bolnikih z okvaro jeter je treba zdravljenje začeti s 25 mg/dan.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 27 April 1998
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: 6 tablets
Slovenian: 6 tablet
English: This could increase the risk of accidental injury (fall)
Slovenian: To lahko poveča tveganje naključnih poškodb (padcev) pri starejših bolnikih,
English: INFORMATION IN BRAILLE Seroquel 100 mg (or 150 mg, or 200 mg or 300 mg)
Slovenian: PODATKI V BRAILLOVI PISAVI seroquel 100 mg (ali 150 mg ali 200 mg ali 300 mg)
English: Quetiapine is well absorbed and extensively metabolised following oral administration.
Slovenian: Kvetiapin se po peroralnem vnosu dobro absorbira in obsežno presnavlja.
English: • Feeling irritated
Slovenian: • občutek razdražljivosti,
English: For 100 mg, 150 mg, 200 mg and 300 mg tablets pack sizes of 10, 90 are registered.
Slovenian: Za jakosti 100 mg, 150 mg, 200 mg in 300 mg so registrirana tudi pakiranja po 10 in 90 tablet.
English: The pharmacokinetics of sodium valproate and quetiapine were not altered to a clinically relevant extent when co-administered.
Slovenian: Sočasno jemanje natrijevega valproata in kvetiapina ne spremeni njune farmakokinetike v klinično pomembnem obsegu.
English: 1 blister of 6 tablets
Slovenian: 1 pretisni omot po 6 tablet
English: Summary of product characteristics, labelling and package leaflet
Slovenian: POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJE IN NAVODILO ZA
English: 1 blister containing 6 x 25 mg and 2 x 100 mg tablets
Slovenian: 1 pretisni omot, ki vsebuje 6 x 25 mg in 2 x 100 mg tableti
English: Information from clinical trials has shown an increased risk of suicidal thoughts and/or suicidal behaviour in young adults aged less than 25 years with depression.
Slovenian: Podatki iz kliničnih preskušanj kažejo, da pri mlajših odraslih (starih manj kot 25 let) z depresijo obstaja večje tveganje za pojav samomorilnih misli in/ali samomorilnega vedenja.
English: Seroquel XR was dosed in the range of 400 to 800 mg/day and the mean dose was approximately 600 mg/day.
Slovenian: Seroquel SR so uporabljali v odmerkih od 400 do 800 mg/dan in povprečni odmerek je bil približno
English: Tell your doctor if you are taking any of the following medicines:
Slovenian: Povejte svojemu zdravniku, če jemljete:
English: Quetiapine is not recommended for use in children and adolescents below 18 years of age, due to a lack of data to support use in this age group.
Slovenian: Kvetiapina ni priporočljivo uporabljati pri otrocih in mladostnikih, mlajših od 18 let, ker ni podatkov, ki bi podpirali njegovo uporabo v tej starostni skupini.
English: In three placebo-controlled clinical trials, in patients with schizophrenia, using variable doses of quetiapine, there were no differences between the Seroquel and placebo treatment groups in the incidence of EPS or concomitant use of anticholinergics.
Slovenian: Rezultati treh s placebom nadzorovanih kliničnih preskušanj pri bolnikih s shizofrenijo pri različnih odmerkih kvetiapina ne kažejo na razlike glede pogostnosti EPU ali sočasne uporabe antiholinergikov med skupino, ki je prejemala zdravilo Seroquel, in skupino, ki je prejemala placebo.
English: Seroquel contains a substance called quetiapine.
Slovenian: Zdravilo Seroquel vsebuje učinkovino imenovano kvetiapin.
English: In four placebo-controlled clinical trials, evaluating doses of Seroquel up to 800 mg/day for the treatment of moderate to severe manic episodes, two each in monotherapy and as combination therapy to lithium or divalproex, there were no differences between the Seroquel and placebo treatment groups in the incidence of EPS or concomitant use of anticholinergics.
Slovenian: V štirih s placebom nadzorovanih preskušanjih, od katerih so v dveh uporabili kvetiapin kot samostojno zdravljenje in v kombiniranem zdravljenju z litijem ali valproatom, so ocenjevali odmerke zdravila Seroquel do 800 mg/dan pri zdravljenju zmernih do hudih maničnih epizod; opazili niso nobenih razlik v pogostnosti EPU ali sočasne uporabe antiholinergikov med skupino, ki je prejemala zdravilo Seroquel, in skupino, ki je prejemala placebo.
English: 1 blister containing 6 x 25mg, 3 x 100mg and 1 x 200mg tablets
Slovenian: 1 pretisni omot, ki vsebuje 6 x 25 mg, 3 x 100 mg in 1 x 200 mg tableto
English: The rates of weight gain ≥ 7% of baseline body weight in the active arm vs. placebo were 17% vs. 2.5% in the schizophrenia and bipolar mania trials, and 12.5% vs. 6% in the bipolar depression trial.
Slovenian: Delež povečanja telesne mase za ≥ 7 % od izhodiščne je bil v preskušanjih pri shizofreniji in bipolarni maniji v kraku z učinkovino 17 % in v kraku s placebom 2,5 %, v preskušanju pri bipolarni depresiji pa 12,5 % (učinkovina) in 6 %
English: 10 tablets
Slovenian: 10 tablet