FrancophonIA/ELRC3.0 huggingface dataset:
English: Limited data are available in patients with HIV-1 clades other than B (see section 5.1).
Danish: Der foreligger begrænsede data for patienter med andre hiv-1-subtyper end subtype B (se pkt.
English: (CYP450 induction)
Danish: (CYP450-induktion)
English: Viruses isolated from patients on darunavir /ritonavir 600/100 mg twice daily experiencing virologic failure by rebound that were susceptible to tipranavir at baseline remained susceptible to tipranavir after treatment in the vast majority of cases.
Danish: Virusisolater fra patienter i behandling med darunavir/ritonavir 600/100 mg to gange dagligt, som fik virologisk svigt ved rebound, og som var følsomme for tipranavir ved baseline, forblev følsomme for tipranavir efter behandling i langt de fleste tilfælde.
English: Amlodipine, diltiazem, disopyramide, carvedilol, felodipine, flecainide, lidocaine,metoprolol, mexiletine, nifedipine, nicardipine, propafenone, timolol, verapamil (for heart disease) as the therapeutic effect or side effects of these medicines may be increased.
Danish: Du skal fortælle det til din læge, hvis du tager: - Amlodipin, diltiazem, disopyramid, carvedilol, felodipin, flecainid, lidocain, metoprolol, mexiletin, nifedipin, nicardipin, propafenon, timolol, verapamil (til hjertesygdomme), da behandlingsvirkningen eller bivirkninger af denne medicin kan blive forstærket.
English: Co-administration is expected to reduce plasma concentrations of darunavir, ritonavir and cobicistat, which could lead to loss of therapeutic effect and possible development of resistance (see sections 4.4 and 4.5).
Danish: Samtidig administration forventes at reducere plasmakoncentrationen af darunavir, ritonavir og cobicistat, hvilket kan medføre tab af terapeutisk effekt og mulig resistensudvikling (se pkt.
English: Your doctor will determine whether Darunavir Krka tablets is right for the child.
Danish: Din læge vil vurdere, om det er bedst for dit barn at få Darunavir Krka som tabletter.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with boosted darunavir is required.
Danish: Dosisreduktion eller seponering af colchicin anbefales hos patienter med normal nyre- og leverfunktion, hvis behandling med boostet darunavir er nødvendig.
English: Psychiatric disorders common insomnia uncommon depression, disorientation, anxiety, sleep disorder, abnormal dreams, nightmare, decreased libido rare confusional state, altered mood, restlessness
Danish: Psykiske forstyrrelser almindelig søvnløshed ikke almindelig depression, desorientering, angst, søvnforstyrrelser, unormale drømme, mareridt, nedsat libido sjælden konfusion, humørændring, rastløshed
English: Dose for adults who have taken antiretroviral medicines before (your doctor will determine this) Maybe you will require a different dose of Darunavir Krka which cannot be administered with these 400 or 800 milligram tablets.
Danish: Dosis til voksne, som ikke tidligere har fået hiv-medicin (din læge vil afgøre dette) Du har brug for en anden dosis af Darunavir Krka, som ikke kan sammensættes med 600 mg tabletterne.
English: Even if you feel better, do not stop taking Darunavir Krka and ritonavir without talking to your doctor.
Danish: Selvom du får det bedre, må du ikke stoppe med at tage Darunavir Krka og ritonavir uden først at tale med din læge.
English: Amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine to treat certain heart disorders e.g. abnormal heart beat
Danish: Amiodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin til behandling af visse hjertelidelser som f.eks. unormal hjerterytme
English: ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindrone AUC ↓ 14% norethindrone Cmin ↓ 30% norethindrone Cmax ↔ with darunavir/ritonavir
Danish: ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindron AUC ↓ 14% norethindron Cmin ↓ 30% norethindron Cmax ↔ med darunavir/ritonavir
English: Darunavir Krka, co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection.
Danish: Darunavir Krka, administreret sammen med lavdosis ritonavir, er i kombination med andre antiretrovirale lægemidler indiceret til behandling af patienter med human immundefektvirus (hiv-1)-infektion.
English: Caution should be used in pregnant women with concomitant medications which may further decrease darunavir exposure (see sections 4.5 and 5.2).
Danish: Der skal udvises forsigtighed ved behandling af gravide kvinder, som kræver samtidig medicinsk behandling, der kan medføre en yderligere nedsat eksponering for darunavir (se pkt.
English: Buprenorphine/naloxone 8/2 mg-16/4 mg once daily buprenorphine AUC ↓ 11% buprenorphine Cmin ↔ buprenorphine Cmax ↓ 8% norbuprenorphine AUC ↑ 46% norbuprenorphine Cmin ↑ 71% norbuprenorphine Cmax ↑ 36% naloxone AUC ↔ naloxone Cmin ND naloxone Cmax ↔
Danish: Buprenorphin/naloxon 8/2 mg-16/4 mg en gang daglig buprenorphin AUC ↓ 11% buprenorphin Cmin ↔ buprenorphin Cmax ↓ 8% norbuprenorphin AUC ↑ 46% norbuprenorphin Cmin ↑ 71% norbuprenorphin Cmax ↑ 36% naloxon AUC ↔
English: Patients co-infected with hepatitis B and/or hepatitis C virus Among 1,968 treatment-experienced patients receiving darunavir co-administered with ritonavir 600/100 mg twice daily, 236 patients were co-infected with hepatitis B or C. Co-infected patients were more likely to have baseline and treatment emergent hepatic transaminase elevations than those without chronic viral hepatitis (see section 4.4).
Danish: Patienter co-inficeret med hepatitis B- og/eller hepatitis C-virus Blandt 1.968 behandlingserfarne patienter, der fik darunavir co-administreret med ritonavir 600/100 mg to gange daglig, havde 236 patienter også hepatitis B eller C. Disse patienter havde en større risiko for forhøjelse af hepatisk aminotransferase ved baseline og efter behandlingsstart end patienter uden kronisk viral hepatitis (se pkt.
English: This dose must not exceed the recommended adult dose, which is 800 milligram Darunavir Krka together with 100 milligram ritonavir once a day.
Danish: Dosis må ikke overstige den anbefalede dosis til voksne, som er 800 mg Darunavir Krka sammen med 100 mg ritonavir en gang dagligt.
English: twice daily N=298
Danish: to gange dagligt N=131
English: Concomitant use of boosted darunavir and these antidepressants may increase concentrations of the antidepressant.
Danish: Samtidig brug af boostet darunavir og disse antidepressiva kan øge koncentrationerne af antidepressivummet.
English: Efavirenz in combination with boosted darunavir once daily may result in sub-optimal darunavir Cmin.
Danish: Efavirenz i kombination med boostet darunavir en gang daglig kan medføre suboptimal darunavir Cmin.
English: Rash occurred more commonly in treatment-experienced patients receiving regimens containing darunavir/ritonavir + raltegravir compared to patients receiving darunavir/ritonavir without raltegravir or raltegravir without darunavir (see section 4.8).
Danish: Udslæt forekom hyppigere hos behandlingserfarne patienter, der blev behandlet med darunavir/ritonavir + raltegravir, end hos patienter, der fik darunavir/ritonavir uden raltegravir eller raltegravir uden darunavir (se pkt.
English: No dose adjustment is recommended in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment, however, darunavir should be used with caution in these patients.
Danish: Dosisjustering anbefales ikke til patienter med mild (Child-Pugh klasse A) eller moderat (Child-Pugh klasse B) nedsat leverfunktion.
English: The recommended dose of emtricitabine/tenofovir alafenamide is 200/10 mg once daily when used with darunavir with low dose ritonavir.
Danish: Den anbefalede dosis emtricitabin/tenofoviralafenamid er 200/10 mg x 1, når det anvendes med darunavir med lavdosis ritonavir.
English: At week 48, the virologic response, defined as the percentage of patients with confirmed plasma viral load < 50 HIV-1 RNA copies/ml, was evaluated in 16 paediatric patients 15 kg to < 20 kg and 5 paediatric patients 10 kg to < 15 kg receiving darunavir /ritonavir in combination with other antiretroviral agents (see section 4.2 for dosage recommendations per body weight).
Danish: Ved uge 48 blev det virologiske respons, defineret som procentdelen af patienter med bekræftet viral load i plasma < 50 HIV-1 RNA kopier/ml, evalueret hos 16 pædiatriske patienter med legemsvægt 15 kg til < 20 kg og hos 5 pædiatriske patienter med legemsvægt 10 kg til < 15 kg, der fik darunavir/ritonavir i kombination med andre antiretrovirale lægemidler (se pkt.
English: Alternative or additional contraceptive measures are recommended when oestrogen-based contraceptives are co-administered with darunavir and low dose ritonavir.
Danish: Det anbefales at bruge andre eller supplerende svangerskabsforebyggende metoder, når østrogenbaserede kontraceptiva gives sammen med darunavir og lavdosis ritonavir.
English: Medicinal products that affect darunavir exposure (ritonavir as pharmacoenhancer)
Danish: Lægemidler, som påvirker darunavireksponering (ritonavir som farmakoforstærker)
English: The metabolism of alfentanil is mediated via CYP3A, and may as such be inhibited by boosted darunavir.
Danish: Alfentanil metaboliseres via CYP3A og kan dermed hæmmes af boostet darunavir.
English: Therefore, darunavir must not be used in patients with severe hepatic impairment (Child-Pugh Class C) (see sections 4.3, 4.4 and 5.2).
Danish: Darunavir må derfor ikke anvendes til patienter med svært nedsat leverfunktion (Child-Pugh klasse C) (se pkt.
English: Due to an increase in the unbound darunavir plasma concentrations, darunavir should be used with caution in patients with mild or moderate hepatic impairment (see sections 4.2, 4.3 and 5.2).
Danish: På grund af en stigning i plasmakoncentrationen af ubundet darunavir bør darunavir anvendes med forsigtighed hos patienter med let eller moderat nedsat leverfunktion (se pkt.
English: - The other ingredients are cellulose, microcrystalline; crospovidone, hydroxypropylcellulose; silica, colloidal anhydrous; silicified microcrystalline cellulose (cellulose, microcrystalline; silica, colloidal anhydrous) and magnesium stearate (E470b) in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) - only for 400 mg film-coated tablets and red iron oxide (E172) in film coating.
Danish: - Øvrige indholdsstoffer: mikrokrystallinsk cellulose, crospovidon, hydroxypropylcellulose, silica, kolloid vandfri, silicificeret mikrokrystallinsk cellulose (mikrokrystallinsk cellulose; silica, kolloid vandfri) og magnesiumstearat (E470b) i tabletkernen og polyvinylalkohol, macrogol, titandioxid (E171), talcum (E553b), jernoxid, gul (E172) - kun for 400 mg filmovertrukne tabletter og jernoxid, rød (E172) i filmovertrækket.
English: Co-administration of darunavir and ritonavir with other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir, which may result in increased plasma concentrations of darunavir and ritonavir.
Danish: Co-administration af darunavir og ritonavir med andre lægemidler, som hæmmer CYP3A, kan nedsætte darunavir- og ritonavir-clearance, hvilket kan medføre øgede plasmakoncentrationer af darunavir og ritonavir.
English: Cmax, ng/ml AUC24h, ng.h/ml Cmin, ng/ml
Danish: Cmax, ng/ml AUC24t, ng.t/ml Cmin, ng/ml
English: Immune system disorders uncommon immune reconstitution inflammatory syndrome, (drug) hypersensitivity
Danish: Immunsystemet ikke almindelig immunrekonstitutionsinflammatorisk syndrom (IRIS), (lægemiddel)overfølsomhed
English: If you notice after 6 hours, then skip the intake and take the next doses as usual.
Danish: Hvis du kommer i tanke om det efter mere end 6 timer, skal du springe den pågældende dosis over og tage de næste doser som sædvanligt.
English: The pharmacokinetic properties of darunavir, co-administered with ritonavir, have been evaluated in healthy adult volunteers and in HIV-1 infected patients.
Danish: De farmakokinetiske egenskaber af darunavir, co-administreret med ritonavir, er blevet vurderet hos raske, voksne, frivillige forsøgspersoner og hos hiv-1-inficerede patienter.
English: Common side effects (may affect up to 1 in 10 people) vomiting, nausea, abdominal pain or distension, dyspepsia, flatulence headache, tiredness, dizziness, drowsiness, numbness, tingling or pain in hands or feet, loss of strength, difficulty falling asleep.
Danish: Almindelige bivirkninger (kan forekomme hos op til 1 ud af 10 personer) - opkastning, kvalme, mavesmerter eller -udspiling, fordøjelsesbesvær, luft i tarmene - hovedpine, træthed, svimmelhed, døsighed, følelsesløshed, prikken eller smerter i hænder eller fødder, svækkelse af styrke, besvær med at falde i søvn.
English: Darunavir binds primarily to plasma α1-acid glycoprotein.
Danish: Darunavir binder sig især til surt plasma α1-glykoprotein.
English: HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir Lopinavir/ritonavir
Danish: HIV-proteasehæmmere (PI) - med co-administration af lavdosis ritonavir Lopinavir/ritonavir
English: Atorvastatin 10 mg once daily atorvastatin AUC ↑ 3-4 fold atorvastatin Cmin ↑ ≈5.5-10 fold atorvastatin Cmax ↑ ≈2 fold darunavir/ritonavir
Danish: Atorvastatin 10 mg en gang daglig atorvastatin AUC ↑ 3-4 gange atorvastatin Cmin ↑ ≈ 5,510 gange atorvastatin Cmax↑ ≈ 2 gange darunavir/ritonavir
English: After therapy with darunavir has been initiated, patients should be advised not to alter the dosage, dose form or discontinue therapy without discussing with their health care provider.
Danish: Efter indledning af behandling med darunavir skal patienterne rådgives om ikkeat ændre doseringen eller lægemiddelformen eller stoppe med behandlingen undtagen efter aftale med lægen.
English: The evidence of efficacy of darunavir co-administered with ritonavir (600/100 mg twice daily) in ART-experienced patients is based on the 96 weeks analysis of the Phase III trial TITAN in ARTexperienced lopinavir naïve patients, on the 48 week analysis of the Phase III trial ODIN in ARTexperienced patients with no DRV-RAMs, and on the analyses of 96 weeks data from the Phase IIb trials POWER 1 and 2 in ART-experienced patients with high level of PI resistance.
Danish: Virkning af darunavir 600 mg to gange dagligt co-administreret med 100 mg ritonavir to gange dagligt hos ART-erfarne patienter Dokumentationen for virkning af darunavir co-administreret med ritonavir (600/100 mg to gange dagligt), hos ART-erfarne patienter er baseret på 96-ugers-analysen af fase III-studiet TITAN hos ART-erfarne, lopinavir-naive patienter, på analysen efter 48 uger i fase III-studiet ODIN hos ART-erfarne patienter uden DRV-RAMs og på analysen af 96-ugers-data fra fase IIb-studierne POWER 1 og 2 hos ART-erfarne patienter med høj grad af PI-resistens.
English: Concomitant use of other PDE-5 inhibitors for the treatment of erectile dysfunction with boosted darunavir should be done with caution.
Danish: Der skal udvises forsigtighed ved samtidig brug af andre PDE-5hæmmere til behandling af erektil dysfunktion og boostet darunavir.
English: A dose decrease may be needed for these drugs when co-administered with darunavir co-administered with low dose ritonavir.
Danish: Det kan være nødvendigt at nedsætte dosis af disse lægemidler ved co-administration med darunavir co-administreret med lavdosis ritonavir.
English: Concentrations of these medicinal products may be increased when coadministered with boosted darunavir resulting in the potential for increased adverse events usually associated with these agents.
Danish: Koncentrationerne af disse lægemidler kan øges ved coadministration med boostet darunavir, hvilket kan øge risikoen for de bivirkninger, der normalt ses med disse midler.
English: If you notice after 12 hours, then skip the intake and take the next doses as usual.
Danish: Hvis du kommer i tanke om det efter mere end 12 timer, skal du springe den pågældende dosis over og tage de næste doser som sædvanligt.
English: Concomitant use of darunavir/ritonavir and darunavir/cobicistat with lopinavir/ritonavir, rifampicin and herbal products containing St John's wort, Hypericum perforatum, is contraindicated (see section 4.5).
Danish: Samtidig brug af darunavir/ritonavir og darunavir/cobicistat med lopinavir/ritonavir, rifampicin og naturlægemidler, der indeholder perikon, Hypericum perforatum, er kontraindiceret (se pkt.
English: Darunavir Krka is not for use in children younger than 3 years of age or weighing less than 15 kilograms.
Danish: Darunavir Krka er ikke beregnet til brug til børn under 3 år eller med en legemsvægt under 15 kg.
English: Renal and urinary disorders uncommon acute renal failure, renal failure, nephrolithiasis, increased blood creatinine, proteinuria, bilirubinuria, dysuria, nocturia, pollakiuria rare decreased creatinine renal clearance
Danish: Nyrer og urinveje ikke almindelig akut nyresvigt, nyresvigt, nephrolitiasis, forhøjet kreatinin i blodet, proteinuri, bilirubinuri, dysuri, nocturi, pollakisuri sjælden nedsat kreatininclearance i nyrerne
English: When administered concomitantly with darunavir and low dose ritonavir, the patient's tolerability of bosentan should be monitored.
Danish: Ved samtidig administration af darunavir og lavdosis ritonavir skal patienten monitoreres for tolerabilitet af bosentan.
English: Exposure to these immunosuppressants will be increased when co-administered with boosted darunavir.
Danish: Eksponeringen for disse immunsuppressiva vil øges ved samtidig administration af boostet darunavir.
English: Therefore, darunavir tablets should be taken with ritonavir and with food.
Danish: Darunavir skal derfor tages med ritonavir og med mad.
English: Darunavir co-administered with low dose ritonavir and etravirine 200 mg twice daily can be used without dose adjustments.
Danish: Darunavir kan administreres sammen med lavdosis ritonavir og etravirin 200 mg to gange daglig uden dosisjusteringer.
English: For information on cobicistat pharmacokinetic properties, consult the cobicistat Summary of Product Characteristics.
Danish: For oplysninger om cobicistats farmakokinetiske egenskaber, se produktresuméet for cobicistat.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with darunavir coadministered with low dose ritonavir is required.
Danish: Dosisreduktion eller seponering af colchicin anbefales hos patienter med normal nyre- og leverfunktion, hvis behandling med darunavir administreret sammen med lavdosis ritonavir er nødvendig.
English: In patients taking Darunavir Krka and raltegravir (for HIV infection), rashes (generally mild or moderate) may occur more frequently than in patients taking either medicine separately.
Danish: Patienter, der får Darunavir Krka sammen med raltegravir (mod hiv-infektion), kan hyppigere få udslæt end patienter, der kun får det ene af disse lægemidler.
English: Darunavir Krka600 mg tablets can be used to construct the twice daily 600 mg regimen.
Danish: Darunavir Krka 600 mg tabletter kan anvendes til at sammensætte regimet med 600 mg to gange dagligt.
English: If concomitant use of boosted darunavir with sildenafil, vardenafil or tadalafil is indicated, sildenafil at a single dose not exceeding 25 mg in 48 hours, vardenafil at a single dose not exceeding 2.5 mg in 72 hours or tadalafil at a single dose not exceeding 10 mg in 72 hours is recommended.
Danish: Hvis samtidig brug af sildenafil, vardenafil eller tadalafil og boostet darunavir er indiceret, anbefales det at give en enkeltdosis sildenafil på højst 25 mg i løbet af 48 timer, en enkeltdosis vardenafil på højst 2,5 mg i løbet af 72 timer eller en enkeltdosis tadalafil på højst 10 mg i løbet af 72 timer.
English: Clinical monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with darunavir with low dose ritonavir.
Danish: Klinisk monitorering af terapeutiske og uønskede virkninger anbefales, når disse lægemidler administreres sammen med darunavir og lavdosis ritonavir.
English: The use of darunavir co-administered with low dose ritonavir and these anticoagulants is not recommended.
Danish: Brugen af darunavir coadministreret med lavdosis ritonavir og disse antikoagulantia frarådes.
English: When used for birth control, alternative methods of nonhormonal contraception are recommended.
Danish: I forbindelse med svangerskabsforebyggelse anbefales det, at du i stedet anvender prævention, der ikke indeholder hormoner.
English: ODIN is a Phase III, randomised, open-label trial comparing darunavir/ritonavir 800/100 mg once daily versus darunavir/ritonavir 600/100 mg twice daily in ART-experienced HIV-1 infected patients with screening genotype resistance testing showing no darunavir RAMs (i.e. V11I, V32I, L33F, I47V, I50V, I54M, I54L, T74P, L76V, I84V, L89V) and a screening HIV-1 RNA > 1,000 copies/ml.
Danish: ODIN er et randomiseret, åbent fase III-studie, der sammenligner darunavir/ritonavir 800/100 mg en gang dagligt med darunavir/ritonavir 600/100 mg to gange dagligt hos ART-erfarne hiv-1-inficerede patienter, hos hvem screening for genotype-resistens har vist, at der ikke fandtes darunavir-RAMs (dvs. V11I, V32I, L33F, I47V, I50V, I54M, I54L, T74P, L76V, I84V, L89V), og screening for hiv-1-RNA viste > 1.000 kopier/ml.
English: Krka 800 milligram once daily dosing may be used.
Danish: Darunavir Krka 800 mg en gang dagligt kan anvendes.
English: 6/l.
Danish: 6 celler/l
English: Tell your doctor if you notice any musculoskeletal problems.
Danish: - Fortæl din læge, hvis du har problemer med muskler eller knogler.
English: No adjustment of methadone dosage is required when initiating coadministration with boosted darunavir.
Danish: Det er ikke nødvendigt at justere metadondosis, når der påbegyndes behandling med boostet darunavir.
English: Viruses selected in these conditions and showing decreased susceptibility to darunavir (range: 23-50fold) harboured 2 to 4 amino acid substitutions in the protease gene.
Danish: De selekterede vira kunne ikke vokse ved tilstedeværelse af darunavir-koncentrationer over 400 nM. Vira, der blev selekteret under disse betingelser, og som viste reduceret følsomhed over for darunavir (område: 23-50-fold), indeholdt 2 til 4 aminosyresubstitutioner i proteasegenet.
English: Darunavir Krka cannot work properly without ritonavir.
Danish: Darunavir Krka virker ikke korrekt uden ritonavir.
English: Hepatobiliary disorders common hepatic enzyme increased uncommon hepatitis*, cytolytic hepatitis*
Danish: Lever og galdeveje almindelig forhøjede leverenzymer ikke almindelig hepatitis*, cytolytisk hepatitis*
English: These patients received darunavir/ritonavir twice daily in combination with other antiretroviral agents (see section 4.2 for dosage recommendations per body weight).
Danish: Disse patienter fik darunavir/ritonavir to gange dagligt i kombination med andre antiretrovirale lægemidler (se pkt.
English: Concomitant use of sildenafil or tadalafil for the treatment of pulmonary arterial hypertension and boosted darunavir may increase plasma concentrations of sildenafil or tadalafil.
Danish: Samtidig anvendelse af sildenafil eller tadalafil til behandling af pulmonal arteriel hypertension og boostet darunavir kan øge plasmakoncentrationen af sildenafil og tadalafil.
English: Boceprevir 800 mg three times daily boceprevir AUC ↓ 32% boceprevir Cmin ↓ 35% boceprevir Cmax ↓ 25% darunavir AUC ↓ 44% darunavir Cmin ↓ 59% darunavir Cmax ↓ 36%
Danish: Boceprevir 800 mg tre gange daglig boceprevir AUC ↓ 32% boceprevir Cmin ↓ 35% boceprevir Cmax ↓ 25% darunavir AUC ↓ 44% darunavir Cmin ↓ 59% darunavir Cmax ↓ 36%
English: Darunavir co-administered with cobicistat should not be used in vs. indinavir/darunavir/ritonavir 800/400/100 mg twice daily.
Danish: Darunavir co-administreret med cobicistat bør ikke anvendes i to gange daglig vs indinavir/darunavir/ritonavir 800/400/100 mg to gange daglig.