FrancophonIA/ELRC3.0 huggingface dataset:
English: A frequent and potentially serious complication, an increase in serum creatinine and urea, may occur during Sandimmun therapy.
Croatian: Učestala i potencijalno ozbiljna komplikacija, povišenje serumskog kreatinina i ureje, može se javiti uz terapiju Sandimmunom.
English: Ciclosporin increases the exposure to HMG-CoA reductase inhibitors (statins).
Croatian: Ciklosporin povećava izloženost inhibitorima HMG-CoA reduktaze (statinima).
English: Cases reporting chronic morphological changes included arteriolar hyalinosis, tubular atrophy and interstitial fibrosis (see section 4.4).
Croatian: Slučajevi u kojima su zabilježene kronične morfološke promjene uključivali su arteriolarnu hijalinozu, tubularnu atrofiju i intersticijsku fibrozu (vidjeti dio 4.4).
English: It is a clear, yellow to yellow-brownish liquid with a small amount of very fine sediment.
Croatian: To je bistra, žuta do žuto-smećkasta tekućina s malom količinom vrlo finog taloga.
English: If you have been prescribed Sandimmun to treat your psoriasis or atopic dermatitis, you must not be exposed to any UVB-rays or phototherapy during treatment.
Croatian: Ako Vam je propisan Sandimmun za liječenje psorijaze ili atopijskog dermaititsa, ne smijete se izlagati nikakvim UVB zrakama ili fototerapiji tijekom liječenja.
English: Posology The dose ranges given for oral administration are intended to serve as guidelines only.
Croatian: Doziranje Rasponi doza koje se daju za oralnu primjenu služe samo kao smjernice.
English: Pre-existing infections may also be aggravated and reactivation of polyomavirus infections may lead to polyomavirus-associated nephropathy (PVAN) or to JC virus associated progressive multifocal leukopathy (PML).
Croatian: Već postojeće infekcije mogu se pogoršati, a reaktivacija poliomavirusnih infekcija može dovesti do nefropatije povezane s poliomvirusom (PVAN) ili do progresivne multifokalne leukopatije (PML) povezane s JC virusom.
English: Azitromycin increases ciclosporin levels by around 20%.
Croatian: Azitromicin povećava razine ciklosporina za oko 20%.
English: Concomitant use of ciclosporin and tacrolimus should be avoided due to the risk for nephrotoxicity and pharmacokinetic interaction via CYP3A4 and/or P-gp (see section 4.4).
Croatian: Istodobna primjena ciklosporina i takrolimusa mora se izbjegavati zbog rizika od nefrotoksičnosti i farmakokinetičke interakcije putem CYP3A4 i/ili P-gp (vidjeti dio 4.4).
English: Co-administration of ciclosporin with bosentan is not recommended (see above subsection “Drugs that decrease ciclosporin levels” and section 4.3).
Croatian: Istodobna primjena ciklosporina s bosentanom se ne preporučuje (vidjeti odjeljak iznad „Lijekovi koji smanjuju razine ciklosporina“ i dio 4.3).
English: Consultation with a physician with experience of use of ciclosporin is recommended.
Croatian: Preporučuje se posavjetovati s liječnikom koji ima iskustva u primjeni ciklosporina.
English: Hepatic function abnormal (see section 4.4)
Croatian: Abnormalna jetrena funkcija (vidjeti dio 4.4)
English: If any of the above applies to you before or during treatment with Sandimmun, tell your doctor straight away.
Croatian: Ako se bilo što od navedenoga odnosi na Vas prije ili tijekom liječenja Sandimmunom, odmah obavijestite svog liječnika.
English: • Kidney problems which may greatly reduce the amount of urine you produce.
Croatian: • Tegobe s bubrezima koje mogu uvelike smanjiti količinu mokraće koju proizvodite.
English: Co-administration of ciclosporin significantly increases blood levels of everolimus and sirolimus.
Croatian: Istodobna primjena ciklosporina značajno povećava razine u everolimusa i sirolimusa u krvi.
English: Do not stop taking Sandimmun unless your doctor tells you to.
Croatian: Nemojte prestati uzimati Sandimmun osim ako Vam to kaže Vaš liječnik.
English: If the eGFR decrease from baseline exceeds 35%, further reduction of the dose of Sandimmun should be considered.
Croatian: Ako smanjenje eGFR-a u odnosu na početnu vrijednost premašuje 35%, valja razmotriti dodatno smanjenje doze Sandimmuna.
English: The terminal half-life ranged from 6.3 hours in healthy volunteers to 20.4 hours in patients with severe liver disease.
Croatian: Terminalni poluvijek kretao se u rasponu od 6,3 sati u zdravih dobrovoljaca do 20,4 sata u bolesnika s teškom bolesti jetre.
English: Products containing Hypericum perforatum (St John´s Wort) must not be used concomitantly with Sandimmun due to the risk of decreased blood levels of ciclosporin and thereby reduced effect (see section 4.3).
Croatian: Proizvodi koji sadrže Hypericum perforatum (gospinu travu) ne smiju se koristiti istodobno sa Sandimmun Neoralom zbog rizika od smanjenih razina ciklosporina u krvi i stoga smanjenog učinka (vidjeti dio 4.3).
English: Ciclosporin passes into breast milk.
Croatian: Ciklosporin prelazi u majčino mlijeko.
English: 50 ml amber glass bottles with an aluminium cap and rubber stopper.
Croatian: Bočice od 50 ml od smeđeg stakla s aluminijskom kapicom i gumenim čepom.
English: With the exception of patients being treated for nephrotic syndrome, patients with impaired renal function should not receive ciclosporin (see subsection on additional precautions in nontransplantation indications in section 4.4).
Croatian: Uz iznimku bolesnika koji se liječe zbog nefrotskog sindroma, bolesnici s oštećenom bubrežnom funkcijom ne smiju primati ciklosporin (vidjeti odjeljak o dodatnim mjerama opreza kod netransplantacijskih indikacija u dijelu 4.4).
English: Various agents are known to either increase or decrease plasma or whole blood ciclosporin levels usually by inhibition or induction of enzymes involved in the metabolism of ciclosporin, in particular CYP3A4.
Croatian: Poznati su razni agensi koji povećavaju ili smanjuju razinu ciklosporina u plazmi ili punoj krvi, obično inhibicijom ili indukcijom enzima uključenih u metabolizam ciklosporina, osobito CYP3A4.
English: This is used to treat tumours, severe psoriasis and severe rheumatoid arthritis.
Croatian: On se koristi za liječenje tumora, teške psorijaze i teškog reumatoidnog artritisa.
English: 4.4 Special warnings and precautions for use
Croatian: 4.4 Posebna upozorenja i mjere opreza pri uporabi Medicinski nadzor
English: If you get high blood pressure during treatment and it cannot be controlled, Sandimmun should be stopped by your doctor.
Croatian: Ako dobijete visoki krvni tlak tijekom liječenja i ne možete ga kontrolirati, liječnik Vam mora obustaviti liječenje
English: In a few psoriatic patients treated with Sandimmun, lymphoproliferative disorders have occurred.
Croatian: U nekoliko bolesnika s psorijazom liječenih Sandimmunom javili su se limfoproliferativni poremećaji.
English: Danazol has been reported to increase ciclosporin blood concentrations by approximately 50%.
Croatian: Zabilježeno je da danazol povećava koncentracije ciklosporina u krvi za oko 50%.
English: Use of Sandimmun in children for non-transplantation indications other than nephrotic syndrome cannot be recommended (see section 4.4).
Croatian: Primjena Sandimmuna u djece s netransplantacijskim indikacijama osim nefrotskog sindroma ne može se preporučiti (vidjeti dio 4.4).
English: When concurrently administered with ciclosporin, the dosage of the statins should be reduced and concomitant use of certain statins should be avoided according to their label recommendations.
Croatian: Kada se primjenjuju istodobno s ciklosporinom, dozu statina treba smanjiti, a istodobnu primjenu određenih statina izbjegavati u skladu s preporukama u njihovim uputama.
English: Patients with impaired renal function (except nephrotic syndrome patients with a permissible degree of renal impairment), uncontrolled hypertension, uncontrolled infections, or any kind of malignancy should not receive ciclosporin.
Croatian: Bolesnici s oštećenom bubrežnom funkcijom (osim bolesnika s nefrotskim sindromom s dopuštenim stupnjem oštećenja bubrega), nekontroliranom hipertenzijom, nekontroliranim infekcijama ili bilo kojom vrstom zloćudne bolesti ne smiju primati ciklosporin.
English: Rheumatoid arthritis Treatment of severe, active rheumatoid arthritis.
Croatian: Reumatoidni artritis Liječenje teškog, aktivnog reumatoidnog artritisa.
English: • Methotrexate.
Croatian: • Metotreksat.
English: Determinations of serum lipids, potassium, magnesium and uric acid are advisable before treatment and periodically during treatment.
Croatian: Savjetuje se i određivanje razina serumskih lipida, kalija, magnezija i mokraćne kiseline prije liječenja te periodički tijekom liječenja.
English: The ethanol content of the Sandimmun formulations should also be taken into account in pregnant women (see section 4.4).
Croatian: Sadržaj etanola u formulacijama Sandimmuna također treba uzeti u obzir kod trudnica (vidjeti dio 4.4.).
English: After use, wipe the syringe on the outside only with a dry tissue and replace it in its cover.
Croatian: Nakon uporabe, obrišite samo vanjsku površinu štrcaljke suhom maramicom i vratite je u njezin spremnik.
English: Sandimmun should not be given to children for a non-transplant disease, except for treatment of nephrotic syndrome.
Croatian: Sandimmun se ne smije davati djeci za netransplantacijsku bolest, osim za liječenje nefrotskog sindroma.
English: In 15 renal transplant patients aged 3 -16 years, ciclosporin whole blood clearance after intravenous administration of Sandimmun was 10.6±3.7 ml/min/kg (assay: Cyclo-trac specific RIA).
Croatian: U 15 bolesnika s bubrežnim presatkom u dobi od 3 -16 godina klirens ciklosporina iz pune krvi nakon intravenske primjene Sandimmuna bio je 10,6±3,7 ml/min/kg (test: Cyclo-trac specifična RIA).
English: Atopic dermatitis Sandimmun is indicated in patients with severe atopic dermatitis when systemic therapy is required.
Croatian: Sandimmun je indiciran u bolesnika s teškim atopijskim dermatitisom u kojih je potrebna sistemska terapija.
English: Higher doses of Sandimmun, or the use of Sandimmun intravenous therapy, may be necessary in the presence of gastrointestinal disturbances which might decrease absorption.
Croatian: Više doze Sandimmuna ili primjena intravenoznog liječenja Sandimmunom mogu biti potrebne u slučaju probavnih poremećaja, koji mogu smanjiti apsorpciju lijeka.
English: Table 1 Summary of exposure changes of commonly used statins with ciclosporin
Croatian: Tablica 1 Sažetak promjena u izloženosti za često korištene statine sa ciklosporinom
English: If you are being treated for Behçet`s uveitis, your doctor will monitor you particularly carefully if you have neurological symptoms (for example: increased forgetfulness, personality changes noticed over time, psychiatric or mood disorders, burning sensation in limbs, decreased sensation in limbs, tingling sensation in limbs, weakness of limbs, walking disturbances, headache with or without nausea and vomiting, vision disturbances including restricted movement of eyeball).
Croatian: Ako se liječite zbog Behçetovog uveitisa, liječnik će Vas pratiti osobito pažljivo ako imate neurološke simptome (na primjer: povećanu zaboravnost, promjene u osobnosti koje primijetite tijekom vremena, psihijatrijske poremećaje ili poremećaje raspoloženja, osjećaj peckanja u udovima, smanjeni osjet u udovima, osjećaj trnaca u udovima, slabost udova, poremećaje u hodu, glavobolju sa ili bez mučnine i povraćanja, poremećaje vida uključujući ograničeno kretnje očne jabučice).
English: Of the many drugs reported to interact with ciclosporin, those for which the interactions are adequately substantiated and considered to have clinical implications are listed below.
Croatian: Od mnogih zabilježenih interakcija lijekova s ciklosporinom navedene su one koje su objašnjene na odgovarajući način i za koje se smatra da imaju kliničkog utjecaja.
English: These were responsive to prompt discontinuation.
Croatian: Oni su reagirali na neposredni prekid liječenja.
English: If you stop taking Sandimmun
Croatian: Ako prestanete uzimati Sandimmun
English: Oral doses of ciclosporin of up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia and in a few patients moderately severe, reversible impairment of renal function.
Croatian: Oralne doze ciklosporina do 10 g (oko 150 mg/kg) podnosile su se uz relativno male kliničke posljedice, kao što su povraćanje, omamljenost, glavoblja, tahikardija te u nekoliko bolesnika umjereno teško, reverzibilno oštećenje bubrežne funkcije.
English: Medicinal products known to reduce or increase the bioavailability of ciclosporin: In transplant patients frequent measurement of ciclosporin levels and, if necessary, ciclosporin dosage adjustment is required, particularly during the introduction or withdrawal of the co-administered medication.
Croatian: Lijekovi za koje se zna da smanjuju ili povećavaju bioraspoloživost ciklosporina: u transplantiranih bolesnika potrebno je učestalo mjerenje razina ciklosporina te, ako je nužno, prilagođavanje doze ciklosporina, osobito tijekom uvođenja ili ustezanja pridruženih lijekova.
English: Ciclosporin has been used successfully both in hepatitis C virus (HCV) positive and HCV negative liver transplants recipients.
Croatian: Ciklosporin se uspješno koristio kako u bolesnika s jetrenim presatkom pozitivnih na hepatitis C virus (HCV) tako i u HCV negativnih.
English: All available evidence suggests that ciclosporin acts specifically and reversibly on lymphocytes.
Croatian: Svi raspoloživi dokazi upućuju na to da ciklosporin djeluje specifično i reverzibilno na limfocite.
English: Hyperuricaemia Caution is required when treating patients with hyperuricaemia.
Croatian: Potreban je oprez u liječenju bolesnika s hiperuricemijom.
English: Atopic dermatitis
Croatian: Atopijski dermatitis
English: If you have fructose intolerance, inform your doctor before taking this medicine, as it contains sorbitol.
Croatian: Posebne pomoćne tvari: sorbitol Ako imate intoleranciju na fruktozu, obratite se svom liječniku prije nego što uzmete ovaj lijek zato što sadrži sorbitol.
English: Before initiation of treatment a reliable baseline assessment of renal function should be established by at least two measurements of eGFR.
Croatian: Prije započinjanja liječenja treba pouzdano utvrditi početnu bubrežnu funkciju pomoću najmanje dva mjerenja eGFR-a.
English: • Brain problems with signs such as seizures, confusion, feeling disorientated, being less responsive, personality changes, feeling agitated, sleeplessness, changes to your sight, blindness, coma, paralysis of part or all of the body, stiff neck, loss of coordination with or without unusual speech or eye movements.
Croatian: • Moždani problemi sa znakovima kao što su napadaji, konfuzija, osjećaj dezorijentiranosti, slabija reaktivnost, promjene osobnosti, osjećaj uznemirenosti, nesanica, promjene vida, sljepoća, koma, paraliza dijela ili cijelog tijela, ukočeni vrat, gubitak koordinacije sa ili bez neuobičajenog govora ili pokreta očiju.
English: Steroid-dependent and steroid-resistant nephrotic syndrome, due to primary glomerular diseases such as minimal change nephropathy, focal and segmental glomerulosclerosis, or membranous glomerulonephritis.
Croatian: Nefrotski sindrom ovisan o steroidima ili rezistentan na steroide, zbog primarnih glomerularnih bolesti kao što su nefropatija minimalnih promjena, žarišna i segmentalna glomeruloskleroza ili membranozni glomerulonefritis.
English: The hepatocellular carcinomas and pancreatic islet cell adenomas were not dose related.
Croatian: Hepatocelularni karcinomi i adenomi Langerhansovih otočića nisu bili povezani s dozom.
English: If a significant impairment of renal function occurs, the dosage of the co-administered medicinal product should be reduced or alternative treatment considered.
Croatian: Ako dođe do značajnog oštećenja bubrežne funkcije, dozu istodobno primjenjivanog lijeka treba smanjiti ili razmotriti drugi oblik liječenja.
English: Mothers receiving treatment with Sandimmun should not breast-feed because of the potential of Sandimmun to cause serious adverse drug reactions in breast-fed newborns/infants.
Croatian: Majke koje primaju terapiju Sandimmunom ne smiju dojiti zbog potencijala Sandimmuna da uzrokuje ozbiljne nuspojave u dojene novorođenčadi/dojenčadi.
English: Octreotide decreases oral absorption of ciclosporin and a 50% increase in the ciclosporin dose or a switch to intravenous administration could be necessary.
Croatian: Oktreotid smanjuje apsorpciju peroralnog ciklosporina pa bi moglo biti nužno povećanje doze ciklosporina za 50% ili prebacivanje na intravensku primjenu.
English: unconsciousness.
Croatian: nesvijest.
English: OTHER SPECIAL WARNING(S), IF NECESSARY [To be completed nationally]
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A), AKO JE POTREBNO
English: Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or medication and increased susceptibility for infections.
Croatian: Dozu za starije bolesnike valja oprezno odabrati, obično počinjući od nižih doza, zbog veće učestalosti smanjene jetrene, bubrežne ili srčane funkcije te konkomitantnih bolesti ili lijekova i povećane osjetljivosti na infekcije.
English: Treatment of sight-threatening intermediate or posterior uveitis of non-infectious aetiology in patients in whom conventional therapy has failed or caused unacceptable side effects.
Croatian: Liječenje po vid prijetećeg intermedijarnog ili stražnjeg uveitisa neinfektivne etiologije u bolesnika u kojih konvencionalna terapija nije uspjela ili je uzrokovala neprihvatljive nuspojave.
English: Pregnant women receiving immunosuppressive therapies after transplantation, including ciclosporin and ciclosporin-containing regimens, are at risk of premature delivery (<37 weeks).
Croatian: Trudnice koje primaju imunosupresivne terapije nakon transplantacije, uključujući ciklosporin i protokole koji sadrže ciklosporin, izložene su riziku prijevremenog poroda (<37 tjedana).
English: - Close the bottle with the cap provided.
Croatian: Zatvorite bočicu priloženim zatvaračem.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS BLISTERS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP BLISTERI
English: • The active substance is ciclosporin.
Croatian: • Djelatna tvar je ciklosporin.
English: There have been reports from clinical trials and from the post-marketing setting associated with the use of Sandimmun.
Croatian: Postoje izvješća iz kliničkih ispitivanja i nakon stavljanja lijeka u promet povezana s primjenom Sandimmuna.
English: Pain in your muscles, muscle spasm.
Croatian: • Bol u mišićima, mišićni grčevi.
English: Following concomitant administration of ciclosporin and aliskiren, a P-gp substrate, the Cmax of aliskiren was increased approximately 2.5-fold and the AUC approximately 5-fold.
Croatian: Nakon istodobne primjene ciklosporina i aliskirena, supstrata Pgp-a, Cmax aliskirena povećao se za otprilike 2,5 puta, a AUC za otprilike 5 puta.
English: The medicine will be diluted before use with saline or 5% glucose and then given to you by slow infusion.
Croatian: Ovaj lijek bit će razrijeđen prije uporabe s fiziološkom otopinom ili 5-postotnom glukozom i zatim primijenjen sporom infuzijom.
English: After use, wipe the syringe on the outside only with a dry tissue.
Croatian: Nakon uporabe, obrišite samo vanjsku površinu štrcaljke suhom maramicom.
English: This is equivalent to nearly 15 ml beer or 5 ml wine per dose.
Croatian: To je ekvivalentno količini od skoro 15 ml pive ili 5 ml vina po dozi.
English: If Sandimmun is used to initiate therapy, the recommended daily dose is 12.5 to 15 mg/kg given in 2 divided doses, starting on the day before transplantation.
Croatian: Ako liječenje započinje Sandimmunom, preporučena dnevna doza je 12,5 do 15 mg/kg dano u 2 podijeljene doze, počevši od dana prije transplantacije.
English: In patients with nephrotic syndrome treated with immunosuppressants (including ciclosporin), the occurrence of malignancies (including Hodgkin's lymphoma) has occasionally been reported.
Croatian: U bolesnika s nefrotskim sindromom liječenim imunosupresivnim lijekovima (uključujući ciklosporin) povremeno je zabilježena pojava zloćudnih bolesti (uključujući Hodgkinov limfom).
English: Lymphadenopathy observed on treatment with ciclosporin should be regularly monitored.
Croatian: Limfoadenopatiju uočenu tijekom liječenja ciklosporinom valja redovito motriti.
English: If this happens, tell your doctor or pharmacist.
Croatian: Ako se to dogodi, obratite se svom liječniku ili ljekarniku.
English: This may be harmful in alcoholic patients and should be taken into account in pregnant or breast-feeding women, in patients presenting with liver disease or epilepsy, or if the patients is a child.
Croatian: To bi moglo štetiti bolesnicima alkoholičarima, a treba uzeti u obzir kod trudnica ili dojilja, u bolesnika s bolešću jetre ili epilepsijom,
English: • Liver problems and damage with or without yellow skin and eyes, nausea, loss of appetite and dark urine.
Croatian: • Tegobe s jetrom i oštećenje sa ili bez žutila kože i očiju, mučninom, gubitkom apetita i tamnom mokraćom.
English: If the effect is insufficient, the daily dose may then be increased gradually as tolerability permits, but should not exceed 5 mg/kg.
Croatian: Ako je klinički učinak nedovoljan, dnevna doza se može postupno povisiti ovisno o podnošljivosti, ali ne bi smjela prelaziti 5 mg/kg.
English: Sandimmun concentrate for solution for infusion contains approximately 34.4 v/v ethanol (alcohol).
Croatian: Sandimmun koncentrat za otopinu za infuziju sadrži otprilike 34,4 v/v etanola (alkohola).
English: Because of the risk of anaphylaxis (see section 4.4) the use of Sandimmun concentrate for solution for infusion should be reserved for organ transplant patients who are unable to take the medicinal product orally (e.g. shortly after surgery), or in whom absorption of the oral forms might be impaired during episodes of gastrointestinal disorders.
Croatian: Zbog rizika od anafilakse (vidjeti dio 4.4) Sandimmun koncentrat za otopinu za infuziju treba se primjenjivati samo bolesnicima s presatkom koji ne mogu uzimati lijek na usta (npr. ubrzo nakon operacije), ili u kojih bi apsorpcija oralnih oblika mogla biti narušena tijekom epizoda poremećaja probavnog sustava.
English: Once satisfactory response is achieved, the dose should be reduced gradually and, if possible, Sandimmun should be discontinued.
Croatian: Nakon što se postigne zadovoljavajući odgovor, dozu je potrebno postupno smanjivati te, ako je moguće, prekinuti primjenu
English: PHARMACEUTICAL FORM Concentrate for solution for infusion Clear, brown-yellow oleaginous concentrate.
Croatian: OBLIK Koncentrat za otopinu za infuziju Bistri, smećkasto-žuti uljni koncentrat.
English: A significantly increased exposure to anthracycline antibiotics (e.g. doxorubicine, mitoxanthrone, daunorubicine) was observed in oncology patients with the intravenous co-administration of anthracycline antibiotics and very high doses of ciclosporin.
Croatian: Značajno povećana izloženost antraciklinskim antibioticima (npr. doksorubicin, mitoksantron, daunorubicin) uočena je u onkoloških bolesnika s istodobnom intravenskom primjenom antraciklinskih antibiotika i vrlo visokih doza ciklosporina.
English: Since Sandimmun can impair renal function, it is necessary to assess renal function frequently.
Croatian: Budući da Sandimmun može oštetiti bubrežnu funkciju, nužno je često procjenjivati bubrežnu funkciju.
English: Patients receiving immunosuppressive therapies, including ciclosporin and ciclosporin-containing regimens, are at increased risk of infections (viral, bacterial, fungal, parasitic) (see section 4.4).
Croatian: Bolesnici koji primaju imunosupresivne terapije, uključujući ciklosporin i protokole koji sadrže ciklosporin, izloženi su povećanom riziku od infekcija (virusnih, bakterijskih, gljivičnih, parazitskih) (vidjeti dio 4.4).
English: The concentrate is a clear brown/yellow oily liquid.
Croatian: Koncentrat je bistra smeđe-žuta uljna tekućina.
English: Push the tube unit with the white stopper firmly into the neck of the bottle.
Croatian: Cjevčicu s bijelim čepom snažno gurnite u grlo bočice.