FrancophonIA/ELRC3.0 huggingface dataset:
English: Remicade must not be used in patients who have experienced hypersensitivity (allergy) to infliximab in the past, or who are hypersensitive (allergic) to mouse proteins or any of the other ingredients of Remicade.
Slovenian: Zdravila Remicade ne smejo uporabljati osebe, pri katerih je v preteklosti prišlo do preobčutljivosti (alergije) na infliksimab, ali pri tistih, ki so preobčutljivi za (alergični na) na mišje beljakovine ali katero koli drugo sestavino zdravila Remicade.
English: It is usually used when other medicines or treatments have failed, in adults with the following diseases:
Slovenian: Navadno se uporablja pri odraslih z naslednjimi obolenji, kadar druga zdravila ali zdravljenja niso bila učinkovita:
English: Ulcerative colitis, ankylosing spondylitis and psoriatic arthritis For ulcerative colitis (728 adults), ankylosing spondylitis (70 adults) and psoriatic arthritis (104 adults), Remicade has been compared with placebo.
Slovenian: Pri ulceroznem kolitisu (728 bolnikov), ankilozirajočem spondilitisu (70 bolnikov) in psoriatičnem artritisu (104 bolniki) so zdravilo Remicade primerjali s placebom.
English: The patients were treated for 6 months with Remicade, another medicine azathioprine, or the combination of Remicade and azathioprine.
Slovenian: Bolnike so šest mesecev zdravili z zdravilom Remicade, azatioprinom (drugim zdravilom) ali s kombinacijo zdravila Remicade in azatioprina.
English: The card will include safety information about the medicine and a record of the dates and results of specific tests that the patient has had so these can be shared with any treating doctor.
Slovenian: Na njej so povzeti podatki o varnosti zdravila ter evidenca datumov in rezultatov posebnih preizkusov, ki jih je bolnik moral opraviti, ki se lahko dajo na vpogled lečečemu zdravniku.
English: In these studies Remicade produced a greater improvement in symptoms, led to fistulae healing in more patients and increased the time that patients continued to respond to treatment.
Slovenian: V teh študijah je zdravilo Remicade v primerjavi s placebom privedlo do večjega izboljšanja simptomov, ozdravljenja fistul pri večjem številu bolnikov ter podaljšalo čas odzivanja bolnikov na zdravljenje.
English: Remicade alone and in combination with azathioprine was more effective than azathioprine alone.
Slovenian: Zdravilo Remicade kot samostojno zdravilo in v kombinaciji z azatioprinom je bilo učinkovitejše od samostojnega zdravljenja z azatioprinom.
English: In a study in 627 adults with psoriasis, Remicade led to a greater improvement in symptoms than placebo.
Slovenian: V študiji, v katero je bilo vključenh 627 odraslih s psoriazo, je zdravilo Remicade v primerjavi s placebom privedlo do večjega izboljšanja simptomov.
English: Remicade can only be obtained with a prescription and must be given under the supervision and monitoring of a specialised doctor who has experience in the diagnosis and treatment of the diseases that Remicade can be used to treat.
Slovenian: Predpisovanje in izdaja zdravila Remicade je le na recept, zdravljenje z njim pa lahko uvede in nadzoruje le zdravnik specialist, ki ima izkušnje z diagnosticiranjem in zdravljenjem bolezni, za katere se to zdravilo uporablja.
English: • Crohn's disease (a disease causing inflammation of the digestive tract), when the disease is moderate to severe or fistulising (with the formation of fistulae, abnormal passageways between the gut and other organs);
Slovenian: • Crohnovo boleznijo (obolenjem, ki povzroča vnetje prebavnega trakta), kadar je obolenje zmerno do močno izraženo ali pa prihaja do fistulizacije (s pojavljanjem fistul, tj. nenormalnih prehodov med črevesjem in drugimi organi);
English: Remicade is used with methotrexate (a medicine that acts on the immune system);
Slovenian: Zdravilo Remicade se uporablja skupaj z metotreksatom (zdravilom, ki učinkuje na imunski sistem);
English: In these studies, more patients taking Remicade in combination with methotrexate showed a reduction in symptoms than those taking methotrexate alone, as well as less damage to the joints and greater improvements in physical function.
Slovenian: V teh študijah je do zmanjšanja simptomov prišlo pri večjem številu bolnikov, ki so zdravilo Remicade prejemali skupaj z metotreksatom, kot pri bolnikih, ki so prejemali samo metotreksat, manj je bilo tudi poškodb v sklepih in opaženo večje izboljšanje telesne zmogljivosti.
English: This messenger is involved in causing inflammation and is found at high levels in patients with the diseases that Remicade is used to treat.
Slovenian: Ta prenašalec sodeluje pri povzročanju vnetja in ga je mogoče v velikih koncentracijah najti pri bolnikih z obolenji, za zdravljenje katerih se uporablja zdravilo Remicade.
English: Remicade is an anti-inflammatory medicine.
Slovenian: Zdravilo Remicade je protivnetno zdravilo.
English: More adult patients receiving Remicade had a reduction in symptoms than those receiving placebo.
Slovenian: Zmanjšanje simptomov je bilo opaziti pri več odraslih bolnikih, ki so prejemali zdravilo Remicade, kot pri tistih, ki so prejemali placebo.
English: Remicade is available as a powder that is made up into a solution for infusion (drip into a vein).
Slovenian: Zdravilo Remicade je na voljo je v obliki praška za pripravo raztopine za infundiranje (kapalne infuzije v veno).
English: For the full list of side effects of Remicade, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Remicade, glejte navodilo za uporabo.
English: Remicade contains the active substance infliximab.
Slovenian: Zdravilo Remicade vsebuje učinkovino infliksimab.
English: • psoriasis (a disease causing red, scaly patches on the skin).
Slovenian: • psoriazo (boleznijo, ki povzroča rdeče, luskaste zaplate na koži).
English: How is Remicade used?
Slovenian: Kako se zdravilo Remicade uporablja?
English: • rheumatoid arthritis (an immune system disease causing inflammation of the joints).
Slovenian: • revmatoidnim artritisom (boleznijo imunskega sistema, ki povzroča vnetje sklepov).
English: Remicade is given as an infusion lasting one or two hours.
Slovenian: Zdravilo Remicade se daje v obliki eno- ali dvourne infuzije.
English: • ankylosing spondylitis (a disease causing inflammation and pain in the joints of the spine);
Slovenian: • ankilozirajočim spondilitisom (boleznijo, ki povzroča vnetje in bolečine v sklepih v hrbtenici);
English: • psoriatic arthritis (a disease causing red, scaly patches on the skin and inflammation of the joints);
Slovenian: • psoriatičnim artritisom (boleznijo, ki povzroča nastajanje rdečih in luskinastih zaplat na koži in vnetje sklepov);
English: (Invented) name Strength
Slovenian: (Izmišljeno) ime
English: Date of first authorisation: 23 April 2014 Date of latest renewal: 18 December 2018
Slovenian: Datum prve odobritve: 23. april 2014 Datum zadnjega podaljšanja: 18. december 2018
English: Some patients had more than one amputation.
Slovenian: Nekateri bolniki so imeli več kot eno amputacijo.
English: The mean age was 63 years and 64% were male.
Slovenian: Povprečna starost je bila 63 let, 64% je bilo moških.
English: Vital status was obtained for 99.6% of subjects across the studies.
Slovenian: Podatke o vitalnem statusu so v okviru obeh študij pridobili pri 99,6% preiskovancev.
English: Take the medicine pack with you.
Slovenian: Škatlo z zdravilom vzemite s seboj.
English: • If you forget to take a dose, take it as soon as you remember.
Slovenian: • Če ste pozabili vzeti odmerek, ga vzemite takoj, ko se spomnite.
English: Not known (freqency cannot be estimated from the available data)
Slovenian: Neznana pogostnost (pogostnosti ni mogoče oceniti iz razpoložljivih podatkov)
English: • if you drink alcohol to excess (either every day or from time to time)
Slovenian: • če prekomerno uživate alkohol (bodisi vsakodnevno ali samo občasno)
English: Do not store above 30°C.
Slovenian: Shranjujte pri temperaturi do 30C.
English: The percentage of minor and major amputations is based on the highest level amputation for each patient.
Slovenian: Odstotek manjših in večjih amputacij temelji na največji ravni amputacije pri posameznem bolniku.
English: • about what you can do to prevent dehydration (see section 4 for signs of dehydration).
Slovenian: • kaj lahko storite, da boste preprečili dehidracijo (glejte poglavje 4 za znake dehidracije).
English: The mean Vd ranged between 63-276 litres.
Slovenian: Povprečni Vd je znašal 63-276 litrov.
English: Note: Incidence is based on the number of patients with at least one amputation, and not the total number of amputation events.
Slovenian: Opomba: Incidenca temelji na številu bolnikov z najmaj eno amputacijo in ne na celotnem številu amputacij.
English: A patient's follow-up is calculated from Day 1 to the first amputation event date.
Slovenian: Trajanje spremljanja bolnika je računano od 1. dne v študiji do datuma prve amputacije.
English: 17% of patients were Hispanic.
Slovenian: 17% bolnikov je bilo latinskoameriškega izvora.
English: In patients at increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3-6 months.
Slovenian: Pri bolnikih s povečanim tveganjem dodatnega napredovanja okvare ledvic in pri starejših je treba delovanje ledvic oceniti pogosteje, na primer vsake 3--6 mesecev.
English: canagliflozin N = 5,790
Slovenian: kanagliflozin N = 5.790
English: The effect of being homozygote (UGT1A9*3/*3, frequency < 0.1%) is probably more marked, but has not been investigated.
Slovenian: Verjetno je učinek večji, če je posameznik homozigot (UGT1A9*3/*3, pogostnost < 0,1%), vendar tega niso preiskovali.
English: Severe allergic reaction (rare, may affect up to 1 in 1,000 people) Possible signs of severe allergic reaction may include:
Slovenian: Huda alergijska reakcija (redko, pojavi se lahko pri največ 1 od 1.000 bolnikov) Možni znaki hude alergijske reakcije lahko vključujejo:
English: The amputation results for the Integrated CANVAS Program are shown in table 2.
Slovenian: Z amputacijami povezani rezultati v integriranem programu CANVAS so prikazani v preglednici 2.
English: However, if it is time for the next dose, skip the missed dose.
Slovenian: Če pa je že čas za naslednji odmerek, izpustite pozabljeni odmerek.
English: Vokanamet is not recommended for children and adolescents under 18 years, because data are not available in these patients.
Slovenian: Pri otrocih in mladostnikih, ki so stari manj kot 18 let, uporaba zdravila Vokanamet ni priporočljiva, ker ni razpoložljivih podatkov o uporabi pri teh bolnikih.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking or continuing to take this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo ali preden nadaljujete z jemanjem tega zdravila.
English: • if you have type 1 diabetes because Vokanamet should not be used to treat this condition.
Slovenian: • če imate sladkorno bolezen tipa 1, saj se za zdravljenje te bolezni zdravila Vokanamet ne sme uporabljati.
English: Component of a 3 bottle multipack, can not be sold separately.
Slovenian: Sestavni del skupnega pakiranja s 3 škatlami, ki se jih ne sme izdajati posamezno.
English: What Vokanamet is and what it is used for
Slovenian: Kaj je zdravilo Vokanamet in za kaj ga uporabljamo
English: An eGFR should be assessed before initiation of treatment with metformin containing products and at least annually thereafter.
Slovenian: Vrednost eGFR je treba oceniti pred uvedbo zdravljenja z zdravili, ki vsebujejo metformin, nato pa vsaj enkrat letno.
English: As an underlying mechanism has not been established, risk factors, apart from general risk factors, for amputation are unknown.
Slovenian: Osnovnega mehanizma niso ugotovili, zato dejavniki tveganja za amputacije (razen splošnih dejavnikov tveganja) niso znani.
English: • Swallow the tablet whole with water.
Slovenian: • Tableto pogoltnite celo skupaj z vodo.
English: As precautionary measures, consideration should be given to carefully monitoring patients with a higher risk for amputation events and counselling patients about the importance of routine preventative foot care and maintaining adequate hydration.
Slovenian: Iz previdnosti je treba razmisliti o skrbnem spremljanju bolnikov z večjim tveganjem za dogodke, ki vodijo do amputacije, in opozarjanju bolnikov na pomembnost rutinske preventivne nege stopal in vzdrževanja zadostne hidracije.
English: Treatment with Vokanamet may be restarted when the ketone values are normal and the patient's condition has stabilised.
Slovenian: Zdravljenje z zdravilom Vokanamet je mogoče ponovno uvesti, ko so vrednosti ketonov normalne is se bolnikovo stanje stabilizira.
English: Patients in CANVAS and CANVAS-R were followed for an average of 5.7 and 2.1 years, respectively.
Slovenian: Bolnike v študijah CANVAS in CANVAS-R so v povprečju spremljali 5,7 oziroma 2,1 let.
English: • in muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilisation
Slovenian: • v mišicah poveča občutljivost za insulin, izboljša periferni privzem in koriščenje glukoze
English: • swelling of the face, lips, mouth, tongue, or throat that may lead to difficulty breathing or swallowing.
Slovenian: • otekanje obraza, ustnic, ust, jezika, grla, zaradi česar je lahko oteženo dihanje ali požiranje.
English: Patients had an overall mean age of 59.5 years (range 21 years to 96 years), with 3,135 patients ≥ 65 years of age and 513 patients ≥ 75 years of age.
Slovenian: Povprečna starost vseh bolnikov je bila 59,5 let (od 21 do 96 let), pri čemer je bilo 3.135 bolnikov starih najmanj 65 let, 513 bolnikov pa najmanj 75 let.
English: Secondary endpoints within a sequential conditional hypothesis testing were all-cause mortality and cardiovascular mortality.
Slovenian: Sekundarna opazovana dogodka s sekvenčnim pogojnim testiranjem hipotez sta bila umrljivost iz kateregakoli vzroka in kardiovaskularna umrljivost.
English: These studies were multicenter, multi-national, randomised, double-blind, parallel group, with similar inclusion and exclusion criteria and patient populations.
Slovenian: Gre za multicentrični, mednarodni, randomizirani, dvojno slepi študiji z vzporedno primerjavo zdravljenih skupin, ki imata med seboj podobne vključitvene in izključitvene kriterije in zajemata podobni populaciji bolnikov.
English: Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption, which may very rarely result in clinically significant vitamin B12 deficiency (e.g., megaloblastic anaemia).
Slovenian: Dolgotrajno zdravljenje z metforminom je povezano z zmanjšanjem absorpcije vitamina B12, kar pa le zelo redko povzroči klinično pomembno pomanjkanje vitamina B12 (npr. megaloblastno anemijo).
English: All-cause mortality
Slovenian: Umrljivost iz kateregakoli vzroka
English: What you need to know before you take Vokanamet
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Vokanamet
English: Stop taking this medicine immediately and contact a doctor or the nearest hospital straight away (see section 2).
Slovenian: Takoj prenehajte jemati to zdravilo in nemudoma obvestite zdravnika ali koga v najbližji bolnišnici (glejte poglavje 2).
English: Active-controlled studies
Slovenian: Študije nadzorovane z učinkovino
English: In addition, in such patients greater decreases in eGFR were reported (see sections 4.2 and 4.8).
Slovenian: Poleg tega so pri teh bolnikih poročali tudi o večjem zmanjšanju eGFR (glejte poglavji 4.2 in 4.8).
English: The maximum daily dose of metformin should preferably be divided into 2-3 daily doses.
Slovenian: Najbolje je, da se največji dnevni odmerek metformina je razdeli v 2-3 dnevne odmerke.
English: Necrotising fasciitis of the perineum (Fournier's gangrene)
Slovenian: Nekrotizirajoči fasciitis presredka(Fournierova gangrena)
English: Sixty-six percent of subjects had a history of established cardiovascular disease, with 56% having a history of coronary disease, 19% with cerebrovascular disease, and 21% with peripheral vascular disease; 14% had a history of heart failure.
Slovenian: Šestinšestdeset odstotkov preiskovancev je imelo v anamnezi ugotovljeno kardiovaskularno bolezen, pri čemer jih je imelo 56% v anamnezi koronarno bolezen, 19% cerebrovaskularno bolezen in 21% bolezen perifernega žilja, 14% pa jih je imelo v anamnezi srčno popuščanje.
English: For study results with respect to combination of therapies, effects on glycaemic control and cardiovascular events, and the populations studied, see sections 4.4, 4.5 and 5.1.
Slovenian: Za rezultate študij glede na kombinacije zdravil, učinke na urejenost glikemije in kardiovaskularne dogodke ter preiskovane populacije glejte poglavja 4.4, 4.5 in 5.1.
English: Combinations requiring precautions for use
Slovenian: Kombinacije, pri katerih so potrebni previdnostni ukrepi
English: In controlled clinical studies, Cmax did not exceed 5 μg/mL, even at maximum doses.
Slovenian: V nadzorovanih kliničnih študijah Cmax tudi pri najvišjih odmerkih ni presegal 5 µg/ml.
English: • reduced body temperature and heartbeat
Slovenian: • znižano telesno temperaturo in počasen srčni utrip
English: In the CANVAS Program, median duration of the infection was longer in the canagliflozin group compared to the placebo group.
Slovenian: V programu CANVAS je bila mediana trajanja okužbe daljša v skupini, ki je prejemala kanagliflozin kot v skupini s placebom.
English: At baseline, patients were treated with one or more antidiabetic medications including metformin (77%), insulin (50%), and sulfonylurea (43%).
Slovenian: Ob izhodišču so bolniki prejemali enega ali več antidiabetikov, vključno z metforminom (77%), insulinom (50%) in sulfonilsečnino (43%).
English: You may need more frequent blood glucose and kidney function tests, or your doctor may need to adjust the dose of Vokanamet.
Slovenian: Morda boste morali pogosteje opravljati preiskave glukoze v krvi in delovanje ledvic, zdravnik pa bo morda moral prilagoditi odmerek zdravila Vokanamet.
English: Multiple amputations (some involving both lower limbs) were observed infrequently and in similar proportions in both treatment groups.
Slovenian: Več amputacij pri enem bolniku (v nekaterih primerih odstranitev obeh spodnjih okončin) so opazili le redko in v podobnih deležih pri obeh zdravljenih skupinah.
English: The imbalance occurred as early as the first 26 weeks of therapy.
Slovenian: Razlike so se pojavile že po prvih 26 tednih zdravljenja.
English: The primary endpoint in the CANVAS Program was the time to first occurrence of a MACE.
Slovenian: Primarni opazovani dogodek v programu CANVAS je bil čas do prvega pojava pomembnega kardiovaskularnega neželenega dogodka (MACE).
English: 58% of patients were male.
Slovenian: Oseminpetdeset odstotkov (58%) bolnikov je bilo moškega spola.
English: Gastrointestinal symptoms such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite occur most frequently during initiation of therapy and resolve spontaneously in most cases.
Slovenian: Gastrointestinalni simptomi, kot so navzea, bruhanje, diareja, bolečine v trebuhu in izguba apetita, se najpogosteje pojavljajo ob začetku zdravljenja in v večini primerov spontano izzvenijo.
English: If Fournier's gangrene is suspected, Vokanamet should be discontinued and prompt treatment (including antibiotics and surgical debridement) should be instituted.
Slovenian: Če obstaja sum na Fournierovo gangreno, je treba zdravilo Vokanamet ukiniti in uvesti takojšnje zdravljenje (vključno z antibiotiki in kirurško odstranitvijo prizadetega tkiva).
English: These symptoms could be a sign of a rare but serious or even life-threatening infection, called necrotising fasciitis of the perineum or Fournier's gangrene which destroys the tissue under the skin.
Slovenian: Ti simptomi so lahko znak redke, vendar resne ali celo življenjsko nevarne okužbe, ki se imenuje nekrotizirajoči fasciitis presredka ali Fournierova gangrena, ki uniči tkivo pod kožo.
English: Metformin is excreted unchanged in the urine.
Slovenian: Metformin se izloča z urinom v nespremenjeni obliki.
English: • lower limb amputations (mainly of the toe) especially if you are at high risk of heart disease.
Slovenian: • amputacije spodnjih okončin (večinoma prstov na nogah), še posebej, če imate večje tveganje za bolezni srca
English: OUTER CARTON FOR 1 COMPONENT OF MULTIPACK (WITHOUT BLUE BOX)
Slovenian: ZUNANJA ŠKATLA ENEGA DELA SKUPNEGA PAKIRANJA (BREZ PODATKOV V MODREM OKENCU)
English: • It is important to check your feet regularly and adhere to any other advice regarding foot care and adequate hydration given by your healthcare professional.
Slovenian: • Pomembno je, da si redno pregledujete stopala in upoštevate nasvete zdravstvenih delavcev o negi stopal in vzdrževanju zadostne količine telesnih tekočin (hidracije).
English: In in vitro studies, canagliflozin neither inhibited cytochrome P450 CYP1A2, CYP2A6, CYP2C19, CYP2D6, or CYP2E1, CYP2B6, CYP2C8, CYP2C9, nor induced CYP1A2, CYP2C19, CYP2B6,
Slovenian: V in vitro študijah kanagliflozin pri odmerkih, višjih od terapevtskih, ni niti zaviral izoencimov citokroma P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, ali CYP2E1, CYP2B6, CYP2C8, CYP2C9, niti induciral CYP1A2, CYP2C19, CYP2B6, CYP3A4.
English: Regardless of treatment with canagliflozin or placebo, the risk of amputation was highest in patients with a baseline history of prior amputation, peripheral vascular disease, and neuropathy.
Slovenian: Ne glede na zdravljenje s kanagliflozinom ali placebom je bilo tveganje za amputacijo največje pri bolnikih, ki so imeli ob izhodišču anamnezo predhodne amputacije, bolezen perifernega žilja in nevropatijo.
English: Renal function eGFR should be assessed before treatment initiation and regularly thereafter (see section 4.2).
Slovenian: Delovanje ledvic eGFR je treba oceniti pred uvedbo zdravljenja, nato pa v rednih presledkih (glejte poglavje 4.2).
English: The risk of lower limb amputation was not dose-dependent.
Slovenian: Tveganje za amputacijo spodnje okončine ni bilo odvisno od velikosti odmerka.
English: The Leydig cell tumours are associated with an increase in luteinising hormone (LH), which is a known mechanism of Leydig cell tumour formation in rats.
Slovenian: Tumorji Leydigovih celic so povezani zvišanjem koncentracije luteinizirajočega hormona (LH), kar je že znan mehanizem tvorbe tumorja Leydigovih celic pri podganah.
English: See section 4.4 and description of AR below.
Slovenian: Glejte poglavje 4.4 in opis neželenega učinka spodaj.
English: Patients with baseline HbA1c > 10% to ≤ 12%
Slovenian: Bolniki z izhodiščno koncentracijo HbA1c od > 10% do ≤ 12%
English: Both improvement in glycaemic control and reduction of cardiovascular morbidity and mortality are an integral part of the treatment of type 2 diabetes.
Slovenian: Tako izboljševanje urejenosti glikemije kot zmanjševanje obolevnosti in mortalnosti zaradi kardiovaskularnih bolezni sta bistvena elementa zdravljenja sladkorne bolezni tipa 2.
English: Balanitis or balanoposthitis occurred primarily in uncircumcised male patients which in some instances resulted in phimosis and/or circumcision.
Slovenian: Do balanitisa oziroma balanopostitisa je prihajalo predvsem pri moških bolnikih, ki niso bili obrezani, kar je v nekaterih primerih povzročilo fimozo in/ali vodilo v cirkumcizijo.
English: Lactic acidosis is a medical emergency and must be treated in a hospital.
Slovenian: Laktacidoza je urgentno zdravstveno stanje in ga je treba zdraviti v bolnišnici.
English: Some studies indicate that taking canagliflozin may have contributed to the risk of lower limb amputation (mainly toe and midfoot amputations).
Slovenian: Nekatere študije kažejo, da lahko jemanje kanagliflozina prispeva k tveganju za amputacije spodnjih okončin (večinoma prstov na nogah in dela stopala).