FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients received a median of 5 cycles of maintenance treatment with ALIMTA and 3.5 cycles of placebo.
Danish: Patienterne fik i gennemsnit 5 serier vedligeholdelsesbehandling af ALIMTA og 3,5 serier af placebo.
English: If you experience tiredness, feeling faint, becoming easily breathless or if you look pale (since you might have less haemoglobin than normal which is very common).
Danish: Hvis De føler træthed, svimmelhed, hurtigt mister vejret, eller hvis De er bleg (fordi De muligvis har mindre hæmoglobin end normalt, hvilket er meget almindeligt).
English: Gemcitabine/ cisplatin (N = 830)
Danish: Gemcitabin/ cisplatin (N = 830)
English: The other ingredients are mannitol, hydrochloric acid and sodium hydroxide
Danish: - Øvrige indholdsstoffer: Mannitol, saltsyre og natriumhydroxid.
English: OTHER SPECIAL WARNING(S), IF NECESSARY cytotoxic
Danish: EVENTUELLE ANDRE SÆRLIGE ADVARSLER Cytotoksisk stof.
English: Hrvatska Eli Lilly Hrvatska d.o.o.
Danish: Eli Lilly Hrvatska d.o.o.
English: Efficacy of ALIMTA + cisplatin vs. gemcitabine + cisplatin in first-line non-small cell lung cancer - ITT population and histology subgroups.
Danish: Effekt af ALIMTA + cisplatin mod gemcitabin + cisplatin ved 1. linje-behandling af ikkesmåcellet lungecancer - ITTpopulation og histologiske undergrupper.
English: Mesothelioma
Danish: Mesoteliom
English: CLASSIFICATION FOR SUPPLY
Danish: GENEREL KLASSIFIKATION FOR UDLEVERING
English: There is no relevant use of ALIMTA in the paediatric population in malignant pleural mesothelioma and non-small cell lung cancer.
Danish: Det er ikke relevant at bruge ALIMTA til malignt pleuramesoteliom og ikke-småcellet lungecancer i den pædiatriske population.
English: An insufficient number of patients has been studied with creatinine clearance of below 45 ml/min.
Danish: Der er ikke foretaget studier med tilstrækkeligt mange patienter med en kreatinin-clearance på under 45 ml/min.
English: Clinically relevant Grade 3 and Grade 4 laboratory toxicities were similar between integrated Phase 2 results from three single agent pemetrexed studies (n = 164) and the Phase 3 single agent pemetrexed study described above, with the exception of neutropenia (12.8 % versus 5.3 %, respectively) and alanine aminotransferase elevation (15.2 % versus 1.9 %, respectively).
Danish: De klinisk relevante laboratorierelaterede toksiciteter af grad 3 og 4 var ensartede mellem de integrerede fase 2-resultater fra tre studier med pemetrexed som enkeltstofbehandling (n = 164) og det fase 3-enkeltstofstudie med pemetrexed, som er beskrevet ovenfor, med undtagelse af neutropeni (12,8 % versus 5,3 %) og forhøjet alaninaminotransferase (15,2 % versus 1,9 %).
English: Preparation and administration precautions: As with other potentially toxic anticancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions.
Danish: Forsigtighedsregler i forbindelse med forberedelse og indgivelse: Som med et hvilket som helst andet potentielt toksisk lægemiddel til behandling af kræft skal der udvises forsigtighed ved håndtering og forberedelse af infusionsopløsninger af pemetrexed.
English: If you experience sudden breathlessness, intense chest pain or cough with bloody sputum (uncommon)(may indicate a blood clot in the blood vessels of the lungs)
Danish: Hvis De pludselig får åndenød, stærke smerter i brystet eller hoste med blodigt spyt (ikke almindeligt) (dette kan betyde, at der er en blodprop i en af lungernes blodårer).
English: After reconstitution, the solution contains 25 mg/ml of pemetrexed.
Danish: Efter rekonstitution indeholder opløsningen 25 mg/ml pemetrexed.
English: The relative treatment effect of ALIMTA was internally consistent across subgroups (including disease stage, induction response, ECOG PS, smoking status, gender, histology and age) and similar to that observed in the unadjusted OS and PFS analyses.
Danish: Den relative behandlingseffekt af ALIMTA var internt konsistent imellem undergrupperne (inklusive sygdomsstadie, induktionsrespons, ECOG performancestatus, rygestatus, køn, histologi og alder) og svarende til det, som blev observeret i analyserne for den ikke-justerede totale overlevelse og progressionsfrie overlevelse.
English: Common (may affect up to 1 in 10 people) Allergic reaction: skin rash / burning or prickling sensation Infection including sepsis
Danish: Almindelig (forekommer hos op til 1 ud af 10 patienter) Allergisk reaktion: udslæt/en brændende eller prikkende fornemmelse Infektion, inklusive sepsis (blodforgiftning) Feber
English: ALIMTA at a dose of 500 mg/m2 was studied as a single-agent in 64 chemonaive patients with malignant pleural mesothelioma.
Danish: ALIMTA i en dosis på 500 mg/m2 blev undersøgt som enkeltstofbehandling til 64 patienter med malignt pleuramesoteliom, som ikke tidligere havde modtaget kemoterapi.
English: Unopened vial This medicinal product does not require any special storage conditions.
Danish: Dette lægemiddel kræver ingen særlige forholdsregler vedrørende opbevaring.
English: Common Pain Edema Renal Disorders Common Renal disorders**** Abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; CTCAE = Common Terminology Criteria for Adverse Event; NCI = National Cancer Institute; SGOT = serum glutamic oxaloacectic aminotransferase; SGPT = serum glutamic pyruvic aminotransferase.
Danish: Forkortelser: ALAT = alanin-aminotransferase; ASAT = aspartat-aminotransferase; CTCAE = Common Terminology Criteria for Adverse Event; NCI = National Cancer Institute.
English: However patients with hepatic impairment such as bilirubin > 1.5 times the upper limit of normal and/or aminotransferase > 3.0 times the upper limit of normal (hepatic metastases absent) or > 5.0 times the upper limit of normal (hepatic metastases present) have not been specifically studied.
Danish: Der er dog ikke foretaget specifikke studier med patienter med nedsat leverfunktion såsom bilirubin > 1,5 gange den normale øvre grænseværdi og/eller aminotransferase > 3,0 gange den normale øvre grænseværdi (uden forekomst af levermetastaser) eller > 5,0 gange den normale øvre grænseværdi (med forekomst af levermetastaser).
English: White to either light yellow or green-yellow lyophilised powder.
Danish: Hvidt til lysegult eller grøngult frysetørret pulver.
English: Please tell your doctor or hospital pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Danish: Fortæl altid lægen eller apotekspersonalet, hvis De tager anden medicin eller har gjort det for nylig.
English: Overall response rate** (95 % CI)
Danish: Samlet responsrate** (95 %-CI)
English: Dose reductions for subsequent cycles are based on nadir ANC, platelet count and maximum non-haematologic toxicity seen from the previous cycle (see section 4.2).
Danish: Dosisreduktioner for efterfølgende serier baseres på ANC-nadir, trombocyttal og maksimal ikke-hæmatologisk toksicitet, som er observeret under den foregående serie (se pkt.
English: Table 2 - Dose modification table for ALIMTA (as single agent or in combination) and cisplatin- Non-haematologic toxicities a, b Dose of ALIMTA (mg/m2)
Danish: Tabel 2 - Dosisjustering for ALIMTA (som enkeltstof eller i kombination) og cisplatinikke-hæmatologisk toksicitet a, b Dosis af ALIMTA (mg/m2)
English: Abbreviation: CI = confidence interval * p-value refers to comparison between arms.
Danish: * p-værdi henviser til sammenligning mellem arme.
English: Patients should be monitored for myelosuppression during therapy and pemetrexed should not be given to patients until absolute neutrophil count (ANC) returns to ≥ 1500 cells/mm3 and platelet count returns to ≥ 100,000 cells/mm3.
Danish: Under behandlingen skal patienten monitoreres for myelosuppression, og pemetrexed må ikke gives til patienter, før det absolutte neutrofiltal (ANC) igen er ≥ 1.500 celler/mm3, og trombocyttallet igen er ≥ 100.000 celler/mm3.
English: If you experience bleeding from the gums, nose or mouth or any bleeding that would not stop, reddish or pinkish urine, unexpected bruising (since you might have less platelets than normal which is very common).
Danish: Hvis De bløder fra gummer, næse eller mund eller anden blødning, som ikke vil stoppe, rødlig eller lyserødlig urin, uventede blå mærker (fordi De muligvis har færre blodplader end normalt, hvilket er meget almindeligt).
English: There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore the use of pemetrexed is not recommended (see section 4.4).
Danish: Der foreligger ikke tilstrækkelige data om anvendelse af pemetrexed til patienter med en kreatinin-clearance under 45 ml/min, og pemetrexed anbefales derfor ikke til disse patienter (se pkt.
English: Nephrogenic diabetes insipidus and renal tubular necrosis have been reported in post marketing setting with an unknown frequency.
Danish: Nefrogen diabetes insipidus og renal tubulær nekrose er indberettet efter markedsføring af lægemidlet med hyppigheden "ikke kendt".
English: Data from the originator medicinal product identified 141 cases of pigmentation disorders such as hyperpigmentation (n=48) and pigmentation disorders NEC (n=80) corresponding mostly to blackish or increased pigmentation, positive de-challenge and positive re-challenge in a number of cases was also described.
Danish: Data fra originalpræparatet identificerede 141 tilfælde af pigmenteringslidelser såsom hyperpigmentering (n=48) og pigmenteringsforstyrrelser NEC (not elsewhere classified) (n=80), svarende hovedsagligt til mørk eller forøget pigmentering.
English: Less toxicity and reduction in Grade 3/4 haematologic and non-haematologic toxicities such as neutropenia, febrile neutropenia and infection with Grade 3/4 neutropenia were reported when pre-treatment with folic acid and vitamin B12 was administered.
Danish: Der blev observeret en mindre toksicitet og en reduktion i antallet af hæmatologiske og ikkehæmatologiske toksiciteter af grad 3/4 såsom neutropeni, febril neutropeni og infektion med neutropeni af grad 3/4, når patienterne var i forbehandling med folsyre og B12-vitamin.
English: Hypernatraemia - increased sodium in blood Inflammation of the skin, mainly of the lower limb with swelling, pain and redness
Danish: Øget koncentration af natrium i blodet (hypernatriæmi) Betændelse i huden, hovedsagligt i underbenet med hævelse, smerte og rødme
English: 50 % of previous dose a National Cancer Institute Common Toxicity Criteria (CTC v2.0; NCI 1998)
Danish: 50 % af tidligere dosis a National Cancer Institute Common Toxicity Criteria (CTC v 2.0; NCI 1998)
English: Constipation Common Dyspepsia
Danish: Forstoppelse Almindelig Dyspepsi
English: Women must use effective contraception during treatment with ALIMTA.
Danish: Kvinder skal anvende effektive svangerskabsforebyggende midler under behandlingen med ALIMTA.
English: ALIMTA is given in combination with cisplatin, another anti-cancer medicine, as treatment for malignant pleural mesothelioma, a form of cancer that affects the lining of the lung, to patients who have not received prior chemotherapy.
Danish: ALIMTA anvendes sammen med cisplatin, en anden medicin mod kræft, til behandling af malignt pleuramesoteliom, en kræftform som påvirker lungehinderne, til patienter, som ikke tidligere har fået kemoterapi.
English: Patients must take oral folic acid or a multivitamin containing folic acid (350 to 1000 micrograms) on a daily basis.
Danish: Patienter skal dagligt tage et oralt folsyretilskud eller en multivitamin indeholdende folsyre (350-1.000 mikrogram).
English: Reported symptoms of overdose include neutropenia, anaemia, thrombocytopenia, mucositis, sensory polyneuropathy and rash.
Danish: De rapporterede symptomer ved overdosering omfattede neutropeni, anæmi, trombocytopeni, mucositis, sensorisk polyneuropati og udslæt.
English: A hospital pharmacist, nurse or doctor will have mixed the ALIMTA powder with 9 mg/ml (0.9 %) sodium chloride solution for injection before it is given to you.
Danish: Hospitalsapoteket, lægen eller sygeplejersken blander på forhånd ALIMTA-pulveret med natriumchloridinjektionsvæske 9 mg/ml (0,9%), før det indgives til Dem.
English: Uncommon ( may affect up to 1 in 100 people)
Danish: Ikke almindelig (forekommer hos op til 1 ud af 100 patienter) Akut nyresvigt
English: When using ALIMTA in combination with cisplatin:
Danish: Når ALIMTA tages sammen med cisplatin:
English: A statistically significant improvement of the clinically relevant symptoms (pain and dyspnoea) associated with malignant pleural mesothelioma in the ALIMTA/cisplatin arm (212 patients) versus the cisplatin arm alone (218 patients) was demonstrated using the Lung Cancer Symptom Scale.
Danish: Ved hjælp af lungecancersymptomskalaen blev der påvist en statistisk signifikant bedring af de klinisk relevante symptomer (smerte og dyspnø) i forbindelse med malignt pleuramesoteliom i ALIMTA/cisplatin-armen (212 patienter) versus armen med cisplatin alene (218 patienter).
English: Nadir platelets <50,000 /mm3 regardless of nadir ANC
Danish: Nadir for trombocytter < 50.000 /mm3 uanset ANC-nadir
English: ALIMTA 100 mg contains less than 1 mmol sodium (23 mg) per vial, i.e. essentially ‘sodium-free'
Danish: ALIMTA 100 mg indeholder mindre end 1 mmol natirum (23 mg) pr. hætteglas, dvs. at det stort set er natriumfrit.
English: Common Fever
Danish: Træthed Almindelig Feber
English: Each vial contains an excess of pemetrexed to facilitate delivery of the label amount.
Danish: Hvert hætteglas indeholder tilstrækkeligt pemetrexed til at levere den angivne mængde.
English: Parenteral medicinal products should be inspected visually for particulate matter and discolouration prior to administration.
Danish: Parenterale lægemidler bør kontrolleres visuelt for partikler og misfarvning før indgivelse.
English: Concomitant administration of nephrotoxic drugs (e.g. aminoglycoside, loop diuretics, platinum compounds, cyclosporin) could potentially result in delayed clearance of pemetrexed.
Danish: Samtidig behandling med nefrotoksiske lægemidler (f.eks. aminoglycosid, loopdiuretika, platinforbindelser, ciclosporin) kan resultere i forsinket clearance af pemetrexed.
English: There were no clinically relevant differences observed for the safety profile of ALIMTA plus cisplatin within the histology subgroups.
Danish: Der blev ikke set klinisk relevante forskelle i sikkerhedsprofilen for ALIMTA plus cisplatin inden for de histologiske undergrupper.
English: When prepared as directed, reconstituted and infusion solutions of ALIMTA contain no antimicrobial preservatives.
Danish: Rekonstituerede opløsninger og infusionsopløsninger Ved forberedelse som angivet indeholder rekonstituerede opløsninger og infusionsopløsninger med ALIMTA ikke antimikrobielle konserveringsmidler.
English: In patients with normal renal function (creatinine clearance > 80 ml/min), high doses of non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen > 1600 mg/day) and acetylsalicylic acid at higher dose (> 1.3 g daily) may decrease pemetrexed elimination and, consequently, increase the occurrence of pemetrexed adverse events.
Danish: Hos patienter med en normal nyrefunktion (kreatinin-clearance ≥ 80 ml/min) kan høje doser af nonsteroide anti-inflammatoriske lægemidler (NSAID-præparater såsom ibuprofen > 1600 mg/dag) og acetylsalicylsyre i høje doser (≥ 1,3 g daglig) nedsætte udskillelsen af pemetrexed, og dermed øge forekomsten af bivirkninger relateret til pemetrexed.
English: Serious cardiovascular and cerebrovascular events, including myocardial infarction, angina pectoris, cerebrovascular accident and transient ischaemic attack have been uncommonly reported during clinical studies with pemetrexed, usually when given in combination with another cytotoxic agent.
Danish: Alvorlige kardiovaskulære og cerebrovaskulære bivirkninger, herunder myokardieinfarkt, angina pectoris, cerebrovaskulære hændelser og forbigående iskæmisk anfald er ikke almindeligt rapporteret under kliniske studier med pemetrexed, sædvanligvis når pemetrexed gives i kombination med et andet cytotoksisk lægemiddelstof.
English: Do not use this medicine after the expiry date which is stated on the label and carton This medicine does not require any special storage conditions.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på pakningen efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Children and adolescents There is no relevant use of ALIMTA in the paediatric population
Danish: Børn og unge Det er ikke relevant at bruge ALIMTA til børn og teenagere.
English: ALIMTA 100 mg powder for concentrate for solution for infusion This medicinal product contains less than 1 mmol sodium (23 mg) per vial, i.e. essentially ‘sodiumfree'.
Danish: ALIMTA 100 mg pulver til koncentrat til infusionsvæske, opløsning Lægemiddelet indeholder mindre en 1 mmol natirum (23 mg) pr. hætteglas, dvs. stort set natriumfrit.
English: Pemetrexed can suppress bone marrow function as manifested by neutropenia, thrombocytopenia and anaemia (or pancytopenia) (see section 4.8).
Danish: Pemetrexed kan hæmme knoglemarvsfunktionen, hvilket kan ytre sig som neutropeni, trombocytopeni og anæmi (eller pancytopeni) (se pkt.
English: In patients treated for non-small cell lung cancer after prior chemotherapy, the recommended dose of ALIMTA is 500 mg/m2 BSA administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Danish: Til patienter, der behandles for ikke-småcellet lungecancer efter tidligere behandling med kemoterapi, er den anbefalede dosis af ALIMTA 500 mg/m2 legemesoverflade indgivet som intravenøs infusion over 10 minutter på den første dag i hver 21-dages-serie.
English: - if you are breast-feeding; you must discontinue breast-feeding during treatment with ALIMTA.
Danish: hvis De ammer, skal De afbryde amningen under behandlingen med ALIMTA.
English: There were no clinically relevant differences observed for the safety profile of ALIMTA within the histology subgroups.
Danish: Der blev ikke set nogen klinisk relevante forskelle i sikkerhedsprofilen for ALIMTA inden for de histologiske undergrupper.
English: Nephrogenic diabetes insipidus and renal tubular necrosis were also reported in post marketing setting with pemetrexed alone or with other chemotherapeutic agents.
Danish: Nefrogen diabetes insipidus og renal tubulær nekrose blev også indberettet efter markedsføring af lægemidlet både med pemetrexed alene og i kombination med andre cytostatika.
English: Low haemoglobin level (anaemia) Low platelet count
Danish: Lavt hæmoglobin niveau (anæmi) Lavt antal blodplader
English: No studies on the effects on the ability to drive and use machines have been performed.
Danish: 4.7 Virkning på evnen til at føre motorkøretøj eller betjene maskiner Der er ikke foretaget undersøgelser af påvirkningen af evnen til at køre bil eller betjene maskiner.
English: Parenteral medicinal products must be inspected visually for particulate matter and discolouration prior to administration.
Danish: Parenterale lægemidler skal kontrolleres visuelt for partikler og misfarvning før indgift.
English: Patients received a median of 4 cycles of maintenance treatment with ALIMTA and 4 cycles of placebo.
Danish: Median var 4 serier af vedligeholdelsesbehandling med ALIMTA og 4 serier med placebo.
English: The most commonly reported undesirable effects related to pemetrexed, whether used as monotherapy or in combination, are bone marrow suppression manifested as anaemia, neutropenia, leukopenia, thrombocytopenia; and gastrointestinal toxicities, manifested as anorexia, nausea, vomiting, diarrhoea, constipation, pharyngitis, mucositis, and stomatitis.
Danish: De hyppigst indberettede bivirkninger relateret til pemetrexed ved både monoterapi og kombinationsbehandling, er knoglemarvssuppression med anæmi, neutropeni, leukopeni, trombocytopeni samt gastrointestinal toksicitet med anoreksi, kvalme, opkastning, diaré, forstoppelse, pharyngitis, mucositis og stomatitis.
English: This leaflet was last revised in
Danish: Denne indlægsseddel blev senest ændret { MM/ÅÅÅÅ }
English: Patients treated with ALIMTA and cisplatin required fewer transfusions (16.4% versus 28.9%, p<0.001), red blood cell transfusions (16.1% versus 27.3%, p<0.001) and platelet transfusions (1.8% versus 4.5%, p=0.002).
Danish: Patienter, der blev behandlet med ALIMTA og cisplatin, havde brug for færre transfusioner (16,4 % mod 28,9 %; p<0,001), transfusioner af røde blodlegemer (16,1 % mod 27,3 %; p<0,001) og blodpladetransfusioner (1,8 % mod 4,2 %; p=0,002).
English: Chemical and physical in-use stability of reconstituted and infusion solutions of pemetrexed were demonstrated for 24 hours at refrigerated temperature.
Danish: Rekonstituerede opløsninger og infusionsopløsninger af pemetrexed har vist sig at have en kemisk og fysisk holdbarhed på 24 timer ved køleskabstemperatur.
English: ** Refer to NCI CTCAE Criteria (Version 3.0; NCI 2003) for each grade of toxicity.
Danish: ** Se NCI CTCAE Criteria (Version 3.0; NCI 2003) for hver toksicitetsgrad De viste indberetningsfrekvenser er i henhold til CTCAE version 3.0.
English: Patients with renal impairment (Standard Cockcroft and Gault formula or Glomerular Filtration Rate measured Tc99m-DPTA serum clearance method)
Danish: Patienter med nedsat nyrefunktion (standardformel, der er udviklet af Cockcroft og Gault, eller glomerulær filtrationshastighed baseret på Tc99m-DPTA-serum-clearancemetoden) Pemetrexed udskilles primært uforandret via nyrerne.
English: ALIMTA is also a treatment for patients with advanced stage of lung cancer whose disease has progressed after other initial chemotherapy has been used.
Danish: ALIMTA er også en behandling til patienter med fremskreden lungekræft, hvor sygdommen har udviklet sig, efter anden indledende behandling med kemoterapi har været forsøgt.
English: Pemetrexed is incompatible with diluents containing calcium, including lactated Ringer's Injection and Ringer's Injection.
Danish: Pemetrexid er inkompatibel med opløsningsvæsker, der indeholder calcium, herunder lakteret Ringer's opløsning og Ringer's opløsning.
English: Progression free survival (PFS) and overall response rate were similar between treatment arms: median PFS was 4.8 months for ALIMTA plus cisplatin versus 5.1 months for gemcitabine plus cisplatin (adjusted hazard ratio 1.04; 95% CI = 0.94-1.15), and overall response rate was 30.6% (95% CI = 27.3-33.9) for ALIMTA plus cisplatin versus 28.2% (95% CI = 25.0-31.4) for gemcitabine plus cisplatin.
Danish: Progressionsfri overlevelse (PFS) og størrelsen af det totale respons var ens mellem de to behandlingsarme: Middel PFS var 4,8 måneder for ALIMTA plus cisplatin mod 5,1 måneder for gemcitabin plus cisplatin (justeret hazard ratio 1.04; 95 % CI = 0,94-1,15) og det totale respons var 30,6 % (95 % CI = 27,3- 33,9) for Alimta plus cisplatin mod 28,2 % (95 % CI = 25,0-31,4) for gemcitabin plus cisplatin.
English: Other medicines and ALIMTA
Danish: Brug af anden medicin sammen med ALIMTA
English: MARKETING AUTHORISATION NUMBER(S) EU/1/04/290/001
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (NUMRE) EU/1/04/290/001
English: Pemetrexed is physically incompatible with diluents containing calcium, including lactated Ringer's injection and Ringer's injection.
Danish: Pemetrexed er fysisk inkompatibelt med fortyndinger, der indeholder calcium, heriblandt Ringers laktat og Ringers væske.
English: Anticipated complications of overdose include bone marrow suppression as manifested by neutropenia, thrombocytopenia and anaemia.
Danish: De forventede komplikationer ved overdosering omfattede knoglemarvshæmning, som ytrede sig ved neutropeni, trombocytopeni og anæmi.
English: Nadir platelets <50,000/mm3 with bleedinga, regardless of nadir ANC
Danish: Nadir for trombocytter < 50.000/ mm3 med blødninga uanset ANC-nadir
English: Papendorpseweg 83, 3528 BJ Utrecht
Danish: 3528 BJ Utrecht