FrancophonIA/ELRC3.0 huggingface dataset:
English: Co-administration of atazanavir with grazoprevir-containing products, including elbasvir/grazoprevir fixed dose combination (used to treat chronic hepatitis C infection) is contraindicated because of the increase in grazoprevir and elbasvir plasma concentrations and potential for the increase in risk of ALT elevations associated with increased grazoprevir concentrations (see section 4.3).
Danish: Samtidig administration af Atazanavir med produkter indeholdende grazoprevir inklusive elbasvir/grazoprevir i fastdosis kombination (bruges til behandling af kronisk hepatitis C infektion) er kontraindiceret på grund af stigning i plasmakoncentrationerne af grazoprevir og elbasvir og den potentielle stigning i risiko for ALAT-stigning som er associeret med stigning i koncentrationer af grazoprevir (se pkt.
English: Atazanavir Mylan, co-administered with low dose ritonavir, is indicated for the treatment of HIV-1 infected adults and paediatric patients 6 years of age and older in combination with other antiretroviral medicinal products (see section 4.2).
Danish: Atazanavir Mylan -kapsler, administreret sammen med en lav dosis ritonavir, er indiceret til behandling af HIV-infektion hos voksne og børn fra 6 år og ældre i kombination med andre antiretrovirale lægemidler (se pkt.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Danish: Bør ikke anvendes til patienter med hereditær galaktoseintolerans, total lactasemangel eller glucose/galactosemalabsorption.
English: While the concentration of ethinyloestradiol was increased with atazanavir given alone, due to both UGT and CYP3A4 inhibition by atazanavir, the net effect of atazanavir/ritonavir is a decrease in ethinyloestradiol levels because of the inducing effect of ritonavir.
Danish: Ethinylestradiolkoncentrationen øges, når atazanavir administreres alene pga. atazanavirs hæmmende effekt på både UGT og CYP3A4, hvorimod nettoeffekten af atazanavir/ritonavir vil være et fald i ethinylestradiolkoncentrationen pga. ritonavirs inducerende effekt.
English: Only when atazanavir with ritonavir is co-administered with efavirenz, a dose increase of ritonavir to 200 mg once daily could be considered.
Danish: Kun når atazanavir med ritonavir bliver administreret samtidig med efavirenz, kan en dosisøgning af ritonavir til 200 mg én gang dagligt overvejes.
English: There were fewer treatment discontinuations in the unboosted atazanavir group (1 vs. 4 subjects in the atazanavir + ritonavir group).
Danish: Der var færre behandlingsafbrydelser i gruppen med ikke-boostet atazanavir (1 versus 4 i gruppen med atazanavir + ritonavir).
English: At high doses that lead to high drug exposures, jaundice due to indirect (unconjugated) hyperbilirubinaemia (without associated liver function test changes) or PR interval prolongations may be observed (see sections 4.4 and 4.8).
Danish: Ved høje doser, som kan medføre højt lægemiddeloptag, kan der observeres gulsot på grund af indirekte (ukonjugeret) hyperbilirubinæmi (uden dermed forbundne ændringer i leverfunktionstest) eller forlængelse af PRinterval (se pkt.
English: - in patients with at least one functional CYP2C19 allele, close clinical monitoring for a loss of both voriconazole (clinical signs) and atazanavir (virologic response) efficacy is recommended.
Danish: - hos patienter med mindst én funktionel CYP2C19-allel anbefales tæt klinisk monitorering for manglende virkning af både voriconazol (kliniske tegn) og atazanavir (virologisk respons).
English: Metabolic parameters Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section 4.4).
Danish: Kropsvægt og niveauerne af lipid og glucose i blodet kan stige under antiretroviral behandling (se pkt.
English: Norgestimate Cmin ↑102% (↑77%
Danish: Norgestimat Cmin ↑102% (↑77%
English: This decrease in atazanavir exposure might negatively impact the efficacy of atazanavir.
Danish: Dette fald i atazanavireksponeringen kan påvirke effekten af atazanavir negativt.
English: Therefore, Atazanavir Mylan is contraindicated with medicinal products that are substrates of CYP3A4 and have a narrow therapeutic index: quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine, bepridil, triazolam, orally administered midazolam, and ergot alkaloids, particularly ergotamine and dihydroergotamine (see section 4.3).
Danish: Atazanavir Mylan er derfor kontraindiceret med lægemidler, der er substrater af CYP3A4 og har et snævert terapeutisk indeks: quetiapin, lurasidon, alfuzosin, astemizol, terfenadin, cisaprid, pimozid, quinidin, bepridil, triazolam, oralt administreret midazolam og sekalealkaloider, især ergotamin og dihydroergotamin (se pkt.
English: Stevens-Johnson syndrome (SJS), erythema multiforme, toxic skin eruptions and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome have been reported in patients receiving atazanavir.
Danish: Stevens-Johnsons syndrom (SJS), erythema multiforme, toksiske huderuptioner og lægemiddelfremkaldt udslæt med eosinofili og systemiske symptomer (DRESS-syndrom) har været rapporteret hos patienter i behandling med atazanavir.
English: The concomitant use of quinidine is contraindicated (see section 4.3).
Danish: Samtidig brug af quinidin er kontraindiceret (se pkt.
English: Atazanavir should be discontinued if severe rash develops.
Danish: Atazanavir bør seponeres, hvis der udvikles alvorligt udslæt.
English: When atazanavir and ritonavir are co-administered, the metabolic drug interaction profile for ritonavir may predominate because ritonavir is a more potent CYP3A4 inhibitor than atazanavir.
Danish: Ved samtidig administration af atazanavir og ritonavir kan ritonavirs metaboliske lægemiddelinteraktionsprofil dominere, idet ritonavir er en mere potent CYP3A4-hæmmer end atazanavir.
English: uncommon: torsades de pointes a rare: QTc prolongation a, oedema, palpitation
Danish: ikke almindelig: torsades de pointesa sjælden: QTc-forlængelsea, ødem, palpitation
English: Do not use this medicine after the expiry date which is stated on the label, carton or blister.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på pakningen efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: No significant effect on didanosine and stavudine concentrations was observed.
Danish: Der er ikke set signifikant påvirkning af didanosin- og stavudinkoncentrationerne.
English: Three of 20 infants (15%) born to women treated with atazanavir/ritonavir 300/100 mg and four of 20 infants (20%) born to women treated with atazanavir/ritonavir 400/100 mg experienced grade 3-4 bilirubin.
Danish: Tre ud af 20 spædbørn (15%) født af kvinder i behandling med atazanavir/ritonavir 300/100 mg og 4 ud af 20 spædbørn (20%) født af kvinder i behandling med atazanavir/ritonavir 400/100 mg oplevede grad 3-4 bilirubin.
English: uncommon: muscle atrophy, arthralgia, myalgia; rare: myopathy
Danish: ikke almindelig: muskelatrofi, artralgi, myalgi; sjælden: myopati
English: The co-administration of abacavir and atazanavir is not expected to significantly alter the exposure of abacavir.
Danish: Samtidig administration af abacavir og atazanavir forventes ikke at påvirke abacavirs eksponering signifikant.
English: Concomitant use of Atazanavir Mylan/ritonavir and fluticasone or other glucocorticoids that are metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section 4.5).
Danish: Samtidig brug af Atazanavir Mylan og fluticason, eller andre glukokortikoider, som metaboliseres af CYP3A4, frarådes, medmindre de potentielle fordele ved behandlingen opvejer risikoen for systemiske bivirkninger forårsaget af kortikosteroider, herunder Cushings syndrom og binyrebarksuppression (se pkt.
English: Co-administration of lurasidone with atazanavir is contraindicated as this may increase lurasidone-related toxicity (see section 4.3).
Danish: Samtidig administration af lurasidon og atazanavir er kontraindiceret, da dette kan øge lurasidon-relateret toksicitet (se pkt.
English: In female mice, atazanavir exposure at a dose that produced single-cell necrosis was 12 times the exposure in humans given 400 mg once daily.
Danish: I hunmus var atazanaviroptagelsen ved en dosis, der frembragte enkeltcellenekrose, 12 gange optagelsen hos mennesker, der havde fået 400 mg én gang dagligt.
English: Reversible elevations in indirect (unconjugated) bilirubin related to inhibition of UDP-glucuronosyl transferase (UGT) have occurred in patients receiving atazanavir (see section 4.8).
Danish: Der er set reversible forhøjelser i indirekte (ukonjugeret) bilirubin relateret til hæmning af UDPglucuronosyltransferase (UGT) hos patienter i behandling med atazanavir (se pkt.
English: • that co-administration is not recommended with tenofovir, boceprevir, carbamazepine, phenytoin, phenobarbital, proton pump inhibitors, and buprenorphine.
Danish: De samme anbefalinger for lægemiddelinteraktioner gælder med undtagelse af: at administration sammen med tenofovir, boceprevir, carbamazepin, phenytoin, phenobarbital, protonpumpehæmmere og buprenorphin frarådes.
English: 110 (n=83) 122 (n=60) 121 (n=94) 154 (n=60) NA
Danish: CD4 Middelændring fra Baseline, celler/mm3 Alle patienter 110 (n=83) 122 (n=60) 121 (n=94) 154 (n=60) NA
English: This decrease in atazanavir Cmin, might negatively impact the efficacy of atazanavir.
Danish: Dette fald i atazanavir Cmin kan påvirke effekten af atazanavir negativt.
English: In a fertility and early embryonic development study in rats, atazanavir altered oestrus cycling with no effects on mating or fertility.
Danish: I et studie af fertilitet og tidlig fosterudvikling hos rotter ændrede atazanavir brunstcyklus uden nogen effekt på parring eller fertilitet.
English: Hard capsule
Danish: Hård kapsel.
English: Among patients who received atazanavir 400 mg once daily or atazanavir 300 mg with ritonavir 100 mg once daily, the only adverse reactions of any severity reported very commonly with at least a possible relationship to regimens containing atazanavir and one or more NRTIs were nausea (20%), diarrhoea (10%), and jaundice (13%).
Danish: Blandt patienter, der fik atazanavir 400 mg, én gang dagligt, eller atazanavir 300 mg med 100 mg ritonavir, én gang dagligt, var de eneste meget almindelige bivirkninger, af nogen sværhedsgrad og med mindst en mulig forbindelse til regimer indeholdende atazanavir og én eller flere NRTIer: kvalme (20%), diarré (10%) og gulsot (13%).
English: This medicine comes in blister packs containing 30 or 30 x 1 (unit dose) capsules or in bottles containing 30 or 90 hard capsules.
Danish: Lægemidlet fås i blisterpakninger, der indeholder 30 eller 30 × 1 (enkeltdosis) kapsler eller i flasker med 30 eller 90 hårde kapsler.
English: - in patients without a functional CYP2C19 allele, close clinical and laboratory monitoring of voriconazole-associated adverse events is recommended
Danish: - hos patienter uden en funktionel CYP2C19-allel anbefales tæt klinisk og laboratoriemæssig monitorering for voriconazolrelaterede bivirkninger
English: The effects of hepatic impairment on the pharmacokinetics of atazanavir after a 300 mg dose with ritonavir have not been studied.
Danish: Betydningen af nedsat leverfunktion for farmakokinetik for atazanavir 300 mg med ritonavir er ikke undersøgt.
English: Atazanavir Mylan capsules must be taken with ritonavir and have to be taken with food.
Danish: Atazanavir Mylan-kapsler skal tages sammen med ritonavir og i forbindelse med et måltid.
English: In the majority of patients with at least one functional CYP2C19 allele, a reduction in both voriconazole and atazanavir exposures are expected.
Danish: Hos størstedelen af patienterne med mindst én funktionel CYP2C19-allel forventes en reduktion i eksponering for både voriconazol og atazanavir.
English: If it is almost time for your next dose, do not take the missed dose.
Danish: Hvis det næsten er tid til næste dosis, skal du vente og tage næste dosis til sædvanlig tid og springe den glemte dosis over.
English: Ketoconazole and itraconazole should be used cautiously with atazanavir/ritonavir.
Danish: Ketoconazol og itraconazol bør anvendes med forsigtighed sammen med atazanavir/ritonavir.
English: Serious skin rash, including Stevens-Johnson syndrome, has been reported in patients taking atazanavir.
Danish: Der er rapporteret alvorligt hududslæt, herunder Stevens-Johnsons syndrom (se afsnit 4), hos patienter, der tager atazanavir.
English: common: headache; uncommon: peripheral neuropathy, syncope, amnesia, dizziness, somnolence, dysgeusia
Danish: almindelig: hovedpine ikke almindelig: perifer neuropati, synkope, amnesi, svimmelhed, døsighed, dysgeusi
English: The mechanism is UGT1A1 inhibition.
Danish: Mekanismen er hæmning af UGT1A1.
English: Voriconazole Cmax ↑438% (↑355%
Danish: Voriconazol Cmax ↑438% (↑355%
English: In HIV-infected patients (n=13), multiple dosing of atazanavir 400 mg (without ritonavir) once daily with food produced a geometric mean (CV%) for atazanavir Cmax of 2298 (71) ng/ml, with time to Cmax of approximately 2.0 hours.
Danish: Hos HIV-inficerede patienter (n=13) medførte gentagne doser af atazanavir 400 mg (uden ritonavir) en gang dagligt med føde en geometrisk gennemsnitlig (CV%) atazanavir-Cmax på 2.298 (71) ng/ml, med en tid til Cmax på ca. 2,0 timer.
English: * In a combined analysis from several clinical studies, atazanavir/ritonavir 300/100 mg coadministered with tenofovir disoproxil fumarate 300 mg (n=39) was compared to atazanavir/ritonavir 300/100 mg (n=33).
Danish: * I en kombineret analyse af flere kliniske studier, hvor samtidig administration af atazanavir/ritonavir 300/100 mg og tenofovirdisoproxilfumarat 300 mg (n=39) blev sammenlignet med atazanavir/ritonavir 300/100 mg (n=33).
English: If the co-administration of Atazanavir Mylan with an NNRTI is required, an increase in the dose of both Atazanavir Mylan and ritonavir to 400 mg and 200 mg, respectively, in combination with efavirenz could be considered with close clinical monitoring.
Danish: Ved behov for samtidig administration af Atazanavir Mylan og en NNRTI, kan det overvejes at øge dosis af Atazanavir Mylan og ritonavir til henholdsvis 400 mg og 200 mg, i kombination med efavirenz, og under omhyggelig klinisk monitorering.
English: Fluvastatin
Danish: Pravastatin Fluvastatin
English: In case of withdrawal of ritonavir from the recommended atazanavir-boosted regimen (see section 4.4)
Danish: I tilfælde af seponering af ritonavir fra anbefalet atazanavir-boostet regime (se pkt.
English: Co-administration of voriconazole and Atazanavir Mylan with ritonavir is not recommended, unless an assessment of the benefit/risk justifies the use of voriconazole.
Danish: Samtidig administration af voriconazol og Atazanavir Mylan med ritonavir frarådes, medmindre det vurderes, at fordel/risiko-forholdet berettiger brugen af voriconazol.
English: Norgestimate Cmax ↑68% (↑51%
Danish: Norgestimat Cmax ↑68% (↑51%
English: As a result, greater peak to trough ratios are observed, however at recommended doses, geometric mean atazanavir exposures (Cmin, Cax and AUC) in paediatric patients are expected to be similar to those observed in adults.
Danish: Den geometriske middeleksponering for atazanavir (Cmin, Cmax og AUC ) ved den anbefalede dosering forventes imidlertid at være den samme hos pædiatriske patienter, som er observeret hos voksne.
English: 90 hard capsules.
Danish: 90 hårde kapsler.
English: In clinical studies AI424-397 and AI424-451, paediatric patients 3 months to less than 11 years of age had a mean duration of treatment with atazanavir oral powder of 80 weeks.
Danish: Pædiatriske patienter fra 3 måneder til under 11 år havde i de kliniske studier AI424-397 og AI424451 en gennemsnitlig behandlingsvarighed med atazanavir oralt pulver på 80 uger.
English: Co-administration of Atazanavir Mylan and medicinal products that induce CYP3A4 is not recommended (see sections 4.3 and 4.5).
Danish: Samtidig administration af Atazanavir Mylan og lægemidler, der inducerer CYP3A4 frarådes (se pkt.
English: 3 years For bottles: Use within 90 days of first opening
Danish: Flasker: Skal anvendes inden for 90 dage efter åbning.
English: Reduced plasma concentrations of atazanavir may be the consequence of increased gastric pH if antacids, including buffered medicinal products, are administered with atazanavir.
Danish: Plasmakoncentrationen af atazanavir kan falde, hvis gastrisk pH øges ved samtidig administration af antacida, inklusive lægemidler med buffer, og atazanavir.
English: Atazanavir Mylan dose once daily (mg)
Danish: Atazanavir Mylan daglig dosis (mg)
English: Co-administration with atazanavir may result in increased concentrations of the PDE5 inhibitor and an increase in PDE5-inhibitor-associated adverse events.
Danish: Administration sammen med atazanavir kan medføre øget koncentration af PDE5-hæmmeren og øget risiko for PDE5-hæmmerrelaterede bivirkninger.
English: Co-administration of atazanavir with other hormonal contraceptives or oral contraceptives containing progestogens other than norgestimate or norethindrone has not been studied, and therefore should be avoided (see section 4.5).
Danish: Samtidig administration af atazanavir og andre hormonelle kontraceptionsmidler eller orale kontraceptionsmidler indeholdende andre gestagener end norgestimat eller norethindron er ikke blevet undersøgt og bør derfor undgås (se pkt.
English: In a nonclinical fertility and early embryonic development study in rats, atazanavir altered oestrus cycling with no effects on mating or fertility (see section 5.3).
Danish: I et præklinisk studie af fertiliet og tidlig fosterudvikling hos rotter ændrede atazanavir brunstcyklus uden nogen effekt på parring eller fertilitet (se pkt.
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN
Danish: SÆRLIG ADVARSEL OM, AT LÆGEMIDLET SKAL OPBEVARES
English: The absorption of atazanavir may be reduced in situations where gastric pH is increased irrespective of cause.
Danish: Absorptionen af atazanavir kan reduceres ved øget pH-værdi i maven, uanset årsagen til dette.
English: Norgestimate AUC ↑85% (↑67%
Danish: Norgestimat AUC ↑85% (↑67%
English: CD4 Mean Change from Baseline, cells/mm All patients
Danish: CD4 Middelændring fra Baseline, celler/mm3 Alle patienter
English: Hyperbilirubinaemia
Danish: Hyperbilirubinæmi
English: Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Danish: Stivhed, ømhed og smerter i leddene (især hofte, knæ og skulder) og bevægelsesbesvær er tegn på knoglenekrose.
English: Study 138 is an international randomised, open-label, multicenter, prospective trial of treatment naïve patients comparing atazanavir/ritonavir (300 mg/100 mg once daily) to lopinavir/ritonavir (400 mg/100 mg twice daily), each in combination with fixed dose tenofovir disoproxil fumarate/emtricitabine (300 mg/200 mg tablets once daily).
Danish: Studie 138 er et internationalt, randomiseret, åbent, prospektivt multicenter-studie med ikke tidligere antiretroviralt behandlede patienter, der sammenligner atazanavir/ritonavir (300 mg/100 mg én gang dagligt) med lopinavir/ritonavir (400 mg/100 mg 2 gange dagligt), hver i kombination med en fast dosis tenofovirdisoproxilfumarat/emtricitabin (300 mg/200 mg tabletter én gang dagligt).
English: Efficacy data observed in the 41 paediatric patients aged 6 years to less than 18 years that received Atazanavir capsules with ritonavir are presented in Table 7.
Danish: I tabel 7 ses data for virkningen hos de 41 pædiatriske patienter i alderen fra 6 år til under 18 år, som fik atazanavir-kapsler med ritonavir.
English: No dosage adjustments are needed for fluconazole and atazanavir.
Danish: Dosisjustering er ikke nødvendig for fluconazol og atazanavir.
English: Carbamazepine should be used with caution in combination with atazanavir.
Danish: Carbamazepin bør anvendes med forsigtighed sammen med atazanavir.
English: C-atazanavir, 79% and 13% of the total radioactivity was recovered in the faeces and urine, respectively.
Danish: Efter en enkelt dosis på 400 mg 14C-atazanavir, blev henholdsvis 79% og 13% af den totale radioaktivitet genfundet i fæces og urin.
English: HIV RNA Mean Change from Baseline, log10 copies/ml All patients
Danish: HIV-RNA Middelændring fra Baseline, log10 kopier/ml Alle patienter
English: By as-treated analysis, excluding missing values, the proportions of patients with HIV RNA < 400 copies/ml (< 50 copies/ml) in the atazanavir + ritonavir arm and the lopinavir + ritonavir arm were 55% (40%) and 56% (46%), respectively.
Danish: Andelen af patienter med HIV-RNA <400 kopier/ml (< 50 kopier/ml) i atazanavir + ritonavir-armen og lopinavir + ritonavir-armen var henholdsvis 55% (40%) og 56% (46%).
English: Atazanavir Mylan with ritonavir should be used with caution in patients with mild hepatic impairment.
Danish: Atazanavir Mylan med ritonavir bør anvendes med forsigtighed til patienter med let nedsat leverfunktion.
English: Chronic kidney disease
Danish: Kronisk nyresygdom
English: The mechanism of interaction is decreased solubility of atazanavir as intra-gastric pH increases with H2-blockers.
Danish: Interaktionsmekanismen er nedsat opløselighed af atazanavir pga. intragastrisk pH-stigning med H2blokkere.
English: Six of 20 (30%) women on atazanavir/ritonavir 300/100 mg and 13 of 21 (62%) women on atazanavir /ritonavir 400/100 mg experienced grades 3 to 4 hyperbilirubinaemia.
Danish: Seks ud af 20 (30%) kvinder, der fik atazanavir/ritonavir 300/100 mg og 13 ud af 21 (62%) kvinder, der fik atazanavir/ritonavir 400/100 mg oplevede grad 3 til 4 hyperbilirubinæmi.
English: Talk to your doctor immediately if you get dark (tea-colored) urine, itching, yellowing of your skin or the white part of your eyes, pain around the stomach, pale colored stools or nausea.
Danish: Tal straks med lægen, hvis du får mørkfarvet (tefarvet) urin, kløe, gulfarvning af huden eller det hvide i øjnene, mavesmerter, lys afføring eller kvalme.
English: Concomitant use of St. John's wort with atazanavir may be expected to result in significant reduction in plasma levels of atazanavir.
Danish: Samtidig brug af perikon og atazanavir kan forventes at medføre signifikant fald i atazanavirs plasmaniveau.
English: If withdrawal of ritonavir is medically warranted under restrictive conditions (see section 4.4), special attention should be given to atazanavir interactions that may differ in the absence of ritonavir (see information below Table 2).
Danish: 4.4) er en medicinsk nødvendighed, skal man være særligt opmærksom på interaktioner med atazanavir, som kan være anderledes uden ritonavir (se oplysninger i nedenstående tabel 2).
English: whereas caution should be used with co-administration of atazanavir and parenteral midazolam.
Danish: 4.3), og der bør udvises forsigtighed ved samtidig administration af atazanavir og parenteral midazolam.
English: In clinical study AI424-020, paediatric patients 3 months to less than 18 years of age who received either the oral powder or capsule formulation had a mean duration of treatment with atazanavir of 115 weeks.
Danish: Pædiatriske patienter fra 3 måneder til under 18 år, som fik enten oralt pulver eller kapsler, havde i et klinisk studie AI424-020 en gennemsnitlig behandlingsvarighed med atazanavir på 115 uger.
English: Concentrations of atazanavir with or without ritonavir are expected to be increased in patients with moderately or severely impaired hepatic function (see sections 4.2, 4.3, and 4.4).
Danish: Koncentrationerne af atazanavir med eller uden ritonavir forventes at øges hos patienter med moderat eller svær nedsat leverfunktion (se pkt.
English: Among experienced patients treated with atazanavir 300 mg once daily with 100 mg ritonavir once daily for a median duration of 95 weeks, 53% had Grade 3-4 total bilirubin elevations.
Danish: Blandt behandlingserfarne patienter som fik atazanavir 300 mg én gang dagligt med 100 mg ritonavir én gang dagligt i gennemsnitligt 95 uger, havde 53% grad 3-4 forhøjelse af total bilirubin.