FrancophonIA/ELRC3.0 huggingface dataset:
English: - If you are unable to swallow the capsules, you can open them up and pour the powder into a glass of still water or apple juice.
Swedish: - Om du inte kan svälja kapslarna kan du öppna dem och hälla pulvret i ett glas icke kolsyrat vatten eller äppeljuice.
English: Imatinib is a protein-tyrosine kinase inhibitor which potently inhibits the Bcr-Abl tyrosine kinase at the in vitro, cellular and in vivo levels.
Swedish: Imatinib är en protein-tyrosinkinashämmare med kraftigt hämmande effekt på Bcr-Abl-tyrosinkinas in vitro, på cellulär nivå och in vivo.
English: Imatinib Actavis inhibits the growth of these cells.
Swedish: Imatinib Actavis hämmar tillväxten av dessa celler.
English: When assuming conservatively that patients with missing data were non-responders, CHR was observed in 20/23 (87%) patients, CCyR in 9/23 (39.1%) patients, and MR in 11/23 (47.8%) patients, respectively.
Swedish: Vid konservativt antagande att patienter där data saknades inte svarat på behandlingen observerades FHS hos 20 av 23 (87 %) patienter, FcyS hos 9 av 23 (39,1 %) patienter respektive molekylärt svar hos 11 av 23 (47,8 %) patienter.
English: The total daily dose in children must not exceed 800 mg with CML and 600 mg with Ph+ALL.
Swedish: Den totala dosen till barn skall inte överstiga 800 mg vid KLM och 600 mg vid Ph-positiv ALL.
English: 11th Ion Mihalache Ave, The 1st district, RO-011171 Bucharest
Swedish: 11th Ion Mihalache Ave, The 1st district,
English: Vertigo, tinnitus, hearing loss
Swedish: Yrsel, tinnitus, nedsatt hörsel
English: Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu
Swedish: Ytterligare information om detta läkemedel finns på Europeiska läkemedelsmyndighetens webbplats http://www.ema.europa.eu.
English: The dose can be reduced if not tolerated (see sections 4.2 and 5.2).
Swedish: Dosen kan minskas om den inte tolereras (se avsnitt 4.2 och 5.2).
English: Pack containing either 24, 48, 60, 96, 120 or 180 capsules
Swedish: Förpackningen innehåller antingen 24, 48, 60, 96, 120 eller 180 kapslar.
English: Days 2, 3, 16, and 17
Swedish: 6 doser)iii: dagar 2, 3, 16, och 17
English: In a 39-week monkey study, no NOAEL (no observed adverse effect level) was established at the lowest dose of 15 mg/kg, approximately one-third the maximum human dose of 800 mg based on body surface.
Swedish: I en 39-veckorsstudie på apa, kunde inget NOAEL (nivån för ingen observerad toxisk effekt) bestämmas vid den lägsta dosen 15 mg/kg, ungefär en tredjedel av den maximala dosen av 800 mg/dag till människa baserat på kroppsytan.
English: When the response rate is calculated from patients with at least one valid assessment, the response rate for CHR, CCyR and MR was 20/22 (90.9%), 9/9 (100%) and 11/17 (64.7%), respectively.
Swedish: Beräknat utifrån patienter med minst en giltig utvärdering var svarsfrekvensen för FHS, FCyS och molekylärt svar 20/22 (90,9 %), 9/9 (100 %) respektive 11/17
English: - The other ingredients are cellulose microcrystalline, copovidone, crospovidone, sodium stearyl fumarate, silica (colloidal hydrophobe and colloidal anhydrous), polyvinyl alcohol partly hydrolysed, talc, yellow iron oxide (E172), titanium dioxide (E171), red iron oxide (E172), lecithin (soya) (E322), xanthan gum (E415).
Swedish: - Övriga innehållsämnen är: mikrokristallin cellulosa, kopovidon, krospovidon, natriumstearylfumarat, kisel (hydrofob, kolloidal och kolloidal, vattenfri), polyvinylalkohol delvis hydroliserad, talk, gul järnoxid (E172), titandioxid (E171), röd järnoxid (E172), lecitin (soja) (E322), xantangummi (E415).
English: Imatinib adverse events, i.e. hepatotoxicity, myelosuppression or others, may increase and it has been reported that concomitant use with L-asparaginase could be associated with increased hepatotoxicity (see section 4.8).
Swedish: Biverkningar hos imatinib, t ex levertoxicitet, benmärgssuppression eller andra, kan öka och det har rapporterats att samtidig användning av L-asparaginas skulle kunna vara förknippad med ökad levertoxicitet (se avsnitt 4.8).
English: If cytopenia is unrelated to leukaemia, reduce dose of imatinib to 260 mg/m2.
Swedish: Om cytopenin inte är leukemirelaterad, sänk imatinib-dosen till 260 mg/m2.
English: Improvements were reported in cardiac, nervous, skin/subcutaneous tissue, respiratory/thoracic/mediastinal, musculoskeletal/connective tissue/vascular, and gastrointestinal organ systems.
Swedish: Förbättringar i organsystemen rapporterades för hjärta, nervsystemet, hud/subkutan vävnad, andningsvägar/bröstkorg/mediastinum/muskuloskeletala systemet/bindväv/blodkärl och magtarmkanalen.
English: Dyspnoea, epistaxis, cough
Swedish: Dyspné, epistaxis, hosta
English: Thrombosis/embolism*
Swedish: Ingen känd frekvens: Trombos/embolism*
English: L-ASP (6000 IUnits/m2, IM): day 44
Swedish: L-ASP (6000 IE/m2, IM): dag 44
English: (24 h), days 1, 15; 6-MP 25 mg/m2 oral, days 1-20
Swedish: (24 tim), dagar 1, 15; 6-MP 25 mg/m2 oral, dagar 1-20
English: Imatinib was not considered genotoxic when tested in an in vitro bacterial cell assay (Ames test), an in vitro mammalian cell assay (mouse lymphoma) and an in vivo rat micronucleus test.
Swedish: Imatinib ansågs inte vara genotoxiskt i bakterier, mammalieceller (Ames test, muslymfom) in vitro, och i råttmikronukleus in vivo.
English: In Ph+ ALL patients, there is clinical experience of co-administering imatinib with chemotherapy (see section 5.1), but drug-drug interactions between imatinib and chemotherapy regimens are not well characterised.
Swedish: Det finns klinisk erfarenhet av samtidig administrering av imatinib och kemoterapi (se avsnitt 5.1) hos Ph+ ALL-patienter, men läkemedelsinteraktioner mellan imatinib-och kemoterapibehandlingar är inte väl karakteriserade.
English: 8 Some fatal cases of hepatic failure and of hepatic necrosis have been reported.
Swedish: 8 Ett antal dödsfall i leversvikt och levernekros har rapporterats.
English: Polyvinyl alchol part. hydrolised Talc
Swedish: Polyvinylalkohol delvis hydroliserad Talk
English: If cytopenia is unrelated to leukaemia, reduce dose of imatinib to 400 mg.
Swedish: Om cytopenin inte är leukemirelaterad, sänk imatinib-dosen till 400 mg.
English: Therefore, the use of imatinib in combination requires special precaution.
Swedish: Därför krävs särskild försiktighet vid användning av imatinib i kombination.
English: Posology for Ph+ ALL in adult patients
Swedish: Dosering vid Ph+ALL hos vuxna patienter
English: Hyper-CVAD regimen: CP 300 mg/m2 i.v.
Swedish: Hyper-CVAD-kur: CP 300 mg/m2 i.v.
English: - Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph-positive ALL).
Swedish: - Philadelphia-kromosom-positiv akut lymfoblastisk leukemi (Ph-positiv ALL).
English: Pack containing either 30 or 90 capsules.
Swedish: Förpackningen innehåller antingen 30 eller 90 kapslar.
English: - Difficulty hearing.
Swedish: - Nedsatt hörsel.
English: Papilloma/carcinoma of the preputial/clitoral gland were noted from 30 mg/kg/day onwards, representing approximately 0.5 or 0.3 times the human daily exposure (based on AUC) at 400 mg/day or 800 mg/day, respectively, and 0.4 times the daily exposure in children (based on AUC) at 340 mg/m2/day.
Swedish: Papillom/karcinom i preputiala och klitorala körtlar noterades från 30 mg/kg/dag och uppåt, vilket utgör ungefär 0,5 respektive 0,3 gånger den dagliga exponeringen hos människa (baserat på AUC) vid 400 mg/dag respektive 800 mg/dag och 0,4 gånger den dagliga exponeringen hos barn (baserat på AUC) vid 340 mg/m2/dag.
English: Active substances that may have their plasma concentration altered by imatinib Imatinib increases the mean Cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, indicating an inhibition of the CYP3A4 by imatinib.
Swedish: Aktiva substanser vars plasmakoncentration kan förändras av Imatinib Imatinib ökar genomsnittligt Cmax och AUC för simvastatin (CYP3A4-substrat) 2 respektive 3,5 gånger, vilket visar att CYP3A4 hämmas av imatinib.
English: (q 12 h), days 2-3, for
Swedish: (q 12 tim), dagar 2-3, i 4
English: Total bilirubin: >1.5-3.0 ULN AST: any
Swedish: Totalbilirubin: > 1,5-3,0 ULN ASAT: oavsett värde
English: The renal adenoma/carcinoma, the urinary bladder and urethra papilloma, the small intestine adenocarcinomas, the parathyroid glands adenomas, the benign and malignant medullary tumours of the adrenal glands and the non-glandular stomach papillomas/carcinomas were noted at 60 mg/kg/day, representing approximately 1.7 or 1 times the human daily exposure (based on AUC) at 400 mg/day or 800 mg/day, respectively, and 1.2 times the daily exposure in children (based on AUC) at 340 mg/m2/day.
Swedish: Njuradenom/karcinom, urinblåse-och urinrörspapillom, tunntarmsadenokarcinom, bisköldkörteladenom, benigna och maligna medullära tumörer i binjurar och papillom/karcinom i ickeglandulär magsäck noterades vid 60 mg/kg/dag, vilket utgör ungefär 1,7 eller 1 gång den dagliga exponeringen hos människa (baserat på AUC) vid 400 mg/dag respektive 800 mg/dag, och 1,2 gånger den dagliga exponeringen hos barn (baserat på AUC) vid 340 mg/m2/dag.
English: However, the occurrence of cytopenias was also clearly dependent on the stage of the disease, the frequency of grade 3 or 4 neutropenias (ANC < 1.0 x 109/L) and thrombocytopenias (platelet count < 50 x 109/L) being between 4 and 6 times higher in blast crisis and accelerated phase (59-64% and 44-63% for neutropenia and thrombocytopenia, respectively) as compared to newly diagnosed patients in chronic phase CML (16.7% neutropenia and 8.9% thrombocytopenia).
Swedish: Förekomsten av neutropeni av grad 3 eller 4 (ANC < 1,0 x 109/l) och trombocytopeni (trombocytnivåer < 50 x 109/l) var 4 till 6 gånger högre vid blastkris och i accelererad fas (59-64 % respektive 44-63 % för neutropeni och trombocytopeni) än hos patienter med nyligen diagnostiserad KML i kronisk fas (16,7 % neutropeni och 8,9 % trombocytopeni).
English: Three (3) patients with HES and CEL associated with PDGFR gene re-arrangements were reported in 3 publications.
Swedish: Tre (3) patienter med HES/CEL associerat med rearrangemang av PDGFR-genen har rapporterats i 3 publikationer.
English: Substances that inhibit the cytochrome P450 isoenzyme CYP3A4 activity (e.g. protease inhibitors such as indinavir, lopinavir/ritonavir, ritonavir, saquinavir, telaprevir, nelfinavir, boceprevir; azole antifungals including ketoconazole, itraconazole, posaconazole, voriconazole; certain macrolides such as erythromycin, clarithromycin and telithromycin) could decrease metabolism and increase imatinib concentrations.
Swedish: Substanser som hämmar aktiviteten av cytokrom P450-isoenzymet CYP3A4 (t ex proteashämmare såsom indinavir, lopinavir/ritonavir, ritonavir, saquinavir, telaprevir, nelfinavir, boceprevir; azolantimykotikum inkluderande ketokonazol, itrakonazol, posakonazol, vorikonazol; vissa makrolider såsom erytromycin, klaritromycin och telitromycin) kan minska metabolismen och öka koncentrationen av imatinib.
English: Weakness, pyrexia, anasarca, chills, rigors
Swedish: Svaghet, pyrexi, anasarka, rysningar, stelhet
English: Flushing, haemorrhage
Swedish: Flushing, blödningar
English: The dose of 340 mg/m2 daily is recommended for children with chronic phase CML and advanced phase CML (not to exceed the total dose of 800 mg).
Swedish: Dosen 340 mg/m2 dagligen rekommenderas till barn med KML i kronisk fas respektive KML i avancerad fas (får ej överstiga totaldosen 800 mg).
English: Imatinib Actavis 400 mg film-coated tablets Pack containing either 10, 30, 60 or 90 film-coated tablets
Swedish: Imatinib Actavis 400 mg filmdragerade tabletter Förpackningen innehåller antingen 10, 30, 60 eller 90 filmdragerade tabletter.
English: The most commonly reported (≥ 10%) drug-related adverse reactions in both settings were mild nausea, vomiting, diarrhoea, abdominal pain, fatigue, myalgia, muscle cramps and rash.
Swedish: De vanligast förekommande (≥10 %) läkemedelsrelaterade biverkningarna i båda fallen var lätt illamående, kräkning, diarré, buksmärta, trötthet, myalgi, muskelkramper och hudutslag.
English: 10 hard capsules 30 hard capsules 60 hard capsules 90 hard capusles
Swedish: 10 hårda kapslar 30 hårda kapslar 60 hårda kapslar 90 hårda kapslar
English: Herpes zoster, herpes simplex, nasopharyngitis, pneumonia1, sinusitis, cellulitis, upper respiratory tract infection, influenza, urinary tract infection, gastroenteritis, sepsis
Swedish: Herpes zoster, herpes simplex, nasofaryngit, pneumoni1, sinuit, cellulit, övre luftvägsinfektion, influensa, urinvägsinfektion, gastroenterit, sepsis
English: DEX 40 mg/day on days 1-4 and 11-14, alternated with MTX 1 g/m i.v.
Swedish: dag 4; DEX 40 mg/dag på dagar 1-4 and 11-14, omväxlande med MTX 1 g/m2 i.v.
English: In newly diagnosed chronic phase CML grade 4 neutropenia (ANC < 0.5 x 109/L) and thrombocytopenia (platelet count < 10 x 109/L) were observed in 3.6% and < 1% of patients, respectively.
Swedish: Hos patienter med nyligen diagnostiserad KML i kronisk fas observerades neutropeni av grad 4 (ANC < 0,5 x 109/l) och trombocytopeni (trombocyter < 10 x 109/l) hos 3,6 % respektive < 1 % av patienterna.
English: If you forget to take Imatinib Actavis
Swedish: Om du har glömt att ta Imatinib Actavis
English: 3 On a patient-year basis, cardiac events including congestive heart failure were more commonly observed in patients with transformed CML than in patients with chronic CML.
Swedish: 3 Beräknat på patientår var hjärtbiverkningar inklusive kronisk hjärtsvikt vanligare hos patienter med transformerad KML än hos patienter med kronisk KML.
English: 10 Musculoskeletal pain and related events were more commonly observed in patients with CML than in GIST patients.
Swedish: 10 Muskel-och skelettsmärta och besläktade biverkningar sågs oftare hos patienter med KML än hos patienter med GIST.
English: The compound selectively inhibits proliferation and induces apoptosis in Bcr-Abl positive cell lines as well as fresh leukaemic cells from Philadelphia chromosome positive CML and acute lymphoblastic leukaemia (ALL) patients.
Swedish: Substansen hämmar proliferation selektivt och inducerar apoptos hos såväl Bcr-Abl-positiva cellinjer som hos färska leukemiska celler från patienter med Philadelphiakromosom-positiv KML och akut lymfoblastleukemi (ALL).
English: (1 h), days 26, 46; Ara-C 75 mg/m2 i.v.
Swedish: (1 tim), dagar 26, 46; Ara-C 75 mg/m2 i.v.
English: 6-MP (75 mg/m2/day, PO): days 1-56
Swedish: 6-MP (75 mg/m2/dag, PO): dagar 1-56
English: (1 h) day 1; AraC 60 mg/m2 i.v., days 22-25, 29-32
Swedish: (1 tim) dag 1; Ara-C 60 mg/m2 i.v., dagar 22-25, 29-32
English: EU/1/13/825/001 30 capsules EU/1/13/825/002 90 capsules
Swedish: EU/1/13/825/001 30 kapslar EU/1/13/825/002 90 kapslar
English: Paediatric accelerated phase CML and blast crisis (starting dose 340 mg/m2)
Swedish: KML i accelererad fas och blastkris hos barn (startdos 340 mg/m2)
English: 9 Musculoskeletal pain during treatment with imatinib or after discontinuation has been observed in post-marketing.
Swedish: 9 Muskel- och skelettsmärta under behandling eller efter avslutad behandling med imatinib har observerats efter marknadsintroduktion.
English: Imatinib may increase plasma concentration of other CYP3A4 metabolised drugs (e.g. triazolo-benzodiazepines, dihydropyridine calcium channel blockers, certain HMG-CoA reductase inhibitors, i.e. statins, etc.).
Swedish: Imatinib kan öka plasmakoncentrationen av andra läkemedel som metaboliseras via 3A4 (t ex triazolobenzodiazepiner, kalciumantagonister av dihydropyridintyp, vissa HMG-CoA-reduktashämmare, dvs. statiner).
English: Neutropenia, thrombocytopenia, anaemia
Swedish: Neutropeni, trombocytopeni, anemi
English: - Hot flushes, chills or night sweats.
Swedish: - Heta blodvallningar, frossa eller nattsvettning.
English: Pleural effusion5, pharyngolaryngeal pain, pharyngitis
Swedish: Pleurautgjutning5, faryngolaryngal smärta, faryngit
English: - Signs of infection such as fever, severe chills, sore throat or mouth ulcers.
Swedish: - Tecken på infektion, t.ex. feber, frossbrytningar, ont i halsen eller sår i munnen.
English: Five (5) patients with DFSP and PDGFR gene re-arrangements were reported in 3 publications.
Swedish: Fem (5) patienter med rearrangemang av DFSP och PDGFR-generna har rapporterats i 3 publikationer.
English: DEX (6 mg/m2/day PO): days 1-5; 29-33 6-MP (75 mg/m2/day, PO): days 8-28
Swedish: DEX (6 mg/m2/dag PO): dagar 1-5; 29-33 6-MP (75 mg/m2/dag, PO): dagar 8-28
English: Histopathological examination of decedents revealed cardiomyopathy (both sexes), chronic progressive nephropathy (females) and preputial gland papilloma as principal causes of death or reasons for sacrifice.
Swedish: (båda könen), kronisk progressiv nefropati (honor) och papillom i preputiala körtlar som huvudorsak till död eller orsak till avlivning.
English: PEG-ASP (2500 IUnits/m2, IM): day 4
Swedish: PEG-ASP (2500 IE/m2, IM): dag 4
English: - Pale skin, feeling tired and breathlessness and having dark urine (signs of low levels of red blood cells).
Swedish: - Blekhet, trötthet och andfåddhet med mörk urin (tecken på låg nivå av röda blodkroppar).
English: A large, international, open-label, non-controlled phase II study was conducted in patients with Philadelphia chromosome positive (Ph+) CML in the blast crisis phase of the disease.
Swedish: En stor, internationell, öppen, icke-kontrollerad fas II-studie har genomförts på patienter med Philadelphiakromosom-positiv (Ph+)-KML i blastfas.
English: Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF), PDGF-R, and inhibits PDGF-mediated cellular events.
Swedish: Imatinib är också en hämmare av receptor-tyrosinkinaserna för trombocytrelaterad tillväxtfaktor (platelet-derived growth factor, PDGF), PDGF-R och hämmar PDGF-medierade cellhändelser.
English: Imatinib Actavis 100 mg film-coated tablets Pack containing either 10, 20, 30, 60, 90, 120 or 180 film-coated tablets
Swedish: Imatinib Actavis 100 mg filmdragerade tabletter Förpackningen innehåller antingen 10, 20, 30, 60, 90, 120 eller 180 filmdragerade tabletter.
English: - Unusual hair loss or thinning.
Swedish: - Oväntat kraftigt håravfall eller uttunning av håret.
English: Total bilirubin: >3-10 ULN AST: any ULN = upper limit of normal for the institution AST = aspartate aminotransferase
Swedish: ULN = det institutionella övre normala gränsvärdet ASAT = aspartataminotransferas
English: VCR 2 mg i.v.
Swedish: Underhållsbehandling VCR 2 mg i.v.
English: 5 Pleural effusion was reported more commonly in patients with GIST and in patients with transformed CML (CML-AP and CML-BC) than in patients with chronic CML.
Swedish: 5 Pleurautgjutning rapporterades oftare för patienter med GIST eller transformerad KML (KML AP och KML-BC) än för patienter med kronisk KML.
English: - Severely decreased urine output, feeling thirsty (signs of kidney problems).
Swedish: - Kraftig urinminskning, törst (tecken på njurproblem).
English: Induction therapy (de novo Ph+ ALL)
Swedish: Induktionsbehandling (de novo Ph+ ALL)
English: - Feeling dizzy or weak.
Swedish: - Yrsel eller svaghet.
English: MESNA (360 mg/m2/dose q3h, x 8 doses/day, IV): days 1-5 G-CSF (5 μg/kg, SC): days 6-15 or until ANC > 1500 post nadir IT Methotrexate (age-adjusted): day 1 ONLY Triple IT therapy (age-adjusted): day 8, 15
Swedish: MESNA (360 mg/m2/dos q3tim, x 8 doser/dag, IV): dagar 1-5 G-CSF (5 μg/kg, SC): dagar 6-15 eller tills ANC > 1500 efter nadir IT Metotrexat (åldersjusterad): dag 1 ENBART Trippel IT terapi (åldersjusterad): dag 8, 15
English: Imatinib increases the mean Cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, indicating an inhibition of the CYP3A4 by imatinib.
Swedish: Imatinib ökar genomsnittligt Cmax och AUC för simvastatin (CYP3A4-substrat) 2 respektive 3,5 gånger, vilket visar att CYP3A4 hämmas av imatinib.
English: CPM (300 mg/m2, IV): days 29-33
Swedish: CPM (300 mg/m2, IV): dagar 29-33
English: G-CSF (5 μg/kg, SC): days 27-36 or until ANC > 1500 post nadir ARA-C (3 g/m2, q12h, IV): days 43, 44
Swedish: G-CSF (5 μg/kg, SC): dagar 27-36 eller tills ANC > 1500 efter nadir ARA-C (3 g/m2, q12tim, IV): dagar 43, 44
English: - adult and paediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) integrated with chemotherapy.
Swedish: vuxna och barn med nyligen diagnostiserad Philadelphiakromosom positiv akut lymfoblastisk leukemi (Ph+ ALL) tillsammans med kemoterapi.
English: Caution should be taken when administering imatinib with inhibitors of the CYP3A4 family.
Swedish: Försiktighet skall iakttas när imatinib ges samtidigt som CYP3A4-hämmare.
English: Fluid retention and oedema, fatigue
Swedish: Vätskeretention och ödem, trötthet
English: Hypertension, haematoma, subdural haematoma, peripheral coldness, hypotension, Raynaud's phenomenon
Swedish: Hypertoni, hematom, subduralhematom, perifer kyla, hypotoni, Raynauds fenomen
English: DEX (6 mg/m2/day, PO): days 1-7 and 15-21
Swedish: DEX (6 mg/m2/dag, PO): dagar 1-7 och 15-21
English: Your doctor will tell you exactly how many capsules of Imatinib Actavis to take.
Swedish: Din läkare informerar dig om exakt hur många kapslar Imatinib Actavis du skall ta.
English: Thrombocythaemia, lymphopenia, bone marrow depression, eosinophilia, lymphadenopathy
Swedish: Trombocytemi, lymfopeni, benmärgsdepression, eosinofili, lymfadenopati
English: Five (5) patients with MDS/MPD associated with PDGFR gene re-arrangements were reported in 4 publications.
Swedish: Fem (5) patienter med MDS/MPD associerat med rearrangemang av PDGFR-genen har rapporterats i 4 publikationer.
English: In adults the dose should be reduced from 400 to 300 mg or from 600 to 400 mg, or from 800 mg to 600 mg, and in children from 340 to 260 mg/m2/day.
Swedish: Hos vuxna skall dosen reduceras från 400 mg till 300 mg eller från 600 mg till 400 mg, eller från 800 mg till 600 mg.
English: Therefore, caution is recommended when administering imatinib with CYP3A4 substrates with a narrow therapeutic window (e.g. cyclosporine, pimozide, tacrolimus, sirolimus, ergotamine, diergotamine, fentanyl, alfentanil, terfenadine, bortezomib, docetaxel and quinidine).
Swedish: Av denna anledning rekommenderas försiktighet när imatinib ges tillsammans med CYP3A4-substrat med snävt terapeutiskt intervall (t ex ciklosporin, pimozid, takrolimus, sirolimus, ergotamin, diergotamin, fentanyl, alfentanil, terfenadin, bortezomib, docetaxel och cinkonidin).
English: VCR 1.3 g/m2 i.v., day 1; prednisolone 60 mg/m2 oral, days 1-5
Swedish: Underhållsbehandling VCR 1,3 g/m2 i.v., dag 1; Prednisolon 60 mg/m2 oral, dagar 1-5
English: days 3-5; MTX 15 mg intrathecal, day 1; methylprednisolone 40 mg intrathecal, day 1
Swedish: dagar 3-5; MTX 15 mg intratekal, dag 1; Metylprednisolon 40 mg intratekal, dag 1
English: Nausea, diarrhoea, vomiting, dyspepsia, abdominal pain6
Swedish: Illamående, diarré, kräkningar, dyspepsi, buksmärta6
English: Active substances that may have their plasma concentration altered by imatinib:
Swedish: Aktiva substanser vars plasmakoncentration kan förändras av Imatinib:
English: Methotrexate (20 mg/m2/week, PO): days 8, 15, 22 VP-16 (100 mg/m2, IV): days 29-33
Swedish: Metotrexat (20 mg/m2/vecka, PO): dagar 8, 15, 22 VP-16 (100 mg/m2, IV): dagar 29-33
English: 15 mg intrathecal, days 1, 8, 15, 22; Ara-C 40 mg intrathecal, days 1, 8, 15, 22; methylprednisolone 40 mg intrathecal, days 1, 8, 15, 22
Swedish: mg intratekal, dagar 1, 8, 15, 22; Ara-C 40 mg intratekal, dagar 1, 8, 15, 22; Metylprednisolon 40 mg intratekal, dagar 1, 8, 15, 22
English: Reporting of side effects
Swedish: Dosjustering för biverkningar
English: When and how to take Imatinib Actavis
Swedish: När och hur skall man ta Imatinib Actavis
English: Rash pustular, contusion, sweating increased, urticaria, ecchymosis, increased tendency to bruise, hypotrichosis, skin hypopigmentation, dermatitis exfoliative, onychoclasis, folliculitis, petechiae, psoriasis, purpura, skin hyperpigmentation, bullous eruptions
Swedish: Pustulöst utslag, kontusion, ökad svettning, urtikaria, ekkymos, ökad tendens till blåmärken, hypotrikos, hypopigmentering av huden, exfoliativ dermatit, spruckna naglar, follikulit, petekier, psoriasis, purpura, hyperpigmentering av huden, bullöst utslag