FrancophonIA/ELRC3.0 huggingface dataset:
English: If you stop taking ADENURIC your uric acid levels may begin to rise and your symptoms may worsen due to the formation of new crystals of urate in and around your joints and kidneys.
Danish: Hvis De holder op med at tage ADENURIC, kan niveauet af urinsyre begynde at stige, og Deres symptomer kan blive forværret på grund af dannelsen af nye uratkrystaller i og omkring leddene samt i nyrerne.
English: It is important to keep taking ADENURIC even if you have a flare, as ADENURIC is still working to lower uric acid.
Danish: Det er vigtigt at blive ved med at tage ADENURIC, selv om De får et udbrud, da ADENURIC stadig er i gang med at sænke niveauet af urinsyre.
English: If you have developed Stevens-Johnson Syndrome with the use of febuxostat, you must not be restarted on ADENURIC at any time.
Danish: Hvis De har fået Stevens-Johnsons syndrom i forbindelse med brug af febuxostat, må De ikke begynde at tage ADENURIC igen på et senere tidspunkt.
English: The safety and the efficacy of ADENURIC in children aged below the age of 18 years have not been established.
Danish: ADENURICs sikkerhed og virkning hos børn under 18 år er ikke klarlagt.
English: Overall, the FLORENCE trial did not highlight any particular safety concern in addition to the previous experience with ADENURIC in gout, with the exception of the following three adverse reactions (listed above in table 1).
Danish: Samlet set gav FLORENCE-studiet ikke anledning til bekymring i forhold til konkrete sikkerhedsspørgsmål ud over de tidligere erfaringer med ADENURIC til arthritis urica, med undtagelse af følgende tre bivirkninger (nævnt ovenfor i tabel 1).
English: Febuxostat is rapidly (tmax of 1.0-1.5 h) and well absorbed (at least 84%).
Danish: Febuxostat absorberes hurtigt (tmax på 1,0-1,5 t) og godt (mindst 84 %).
English: If you are having a gout attack at the moment (a sudden onset of severe pain, tenderness, redness, warmth and swelling in a joint), wait for the gout attack to subside before first starting treatment with ADENURIC.
Danish: Hvis De i øjeblikket har et anfald af urinsyregigt (en pludselig, kraftig smerte, ømhed, rødme, varme og hævelse i et led), skal De vente, indtil anfaldet fortager sig, inden De starter på behandlingen med ADENURIC.
English: A. MANUFACTURE(S) RESPONSIBLE FOR BATCH RELEASE
Danish: A. FREMSTILLER(E) ANSVARLIG(E) FOR BATCHFRIGIVELSE
English: Incidence of overall treatment-emergent signs and symptoms and adverse drug reactions was 67.6% vs 64.7% and 6.4% vs 6.4% with ADENURIC and allopurinol respectively.
Danish: Det totale antal tilfælde af behandlingsrelaterede tegn og symptomer samt bivirkninger var 67,6 % versus 64,7 % og 6,4 % vs, 6,4 % for henholdsvis ADENURIC og allopurinol.
English: This has not been observed in the pivotal clinical study with ADENURIC in the Tumor Lysis Syndrome.
Danish: Dette blev ikke observeret i det pivotale kliniske studie af ADENURIC ved tumorlyse-syndrom.
English: 14 film-coated tablets 28 film-coated tablets 42 film-coated tablets 56 film-coated tablets 84 film-coated tablets 98 film-coated tablets
Danish: 14 filmovertrukne tabletter 28 filmovertrukne tabletter 42 filmovertrukne tabletter 56 filmovertrukne tabletter 84 filmovertrukne tabletter 98 filmovertrukne tabletter
English: Менарини България” EООД
Danish: Менарини България” EООД тел.
English: Cardio-vascular disorders Treatment of chronic hyperuricaemia
Danish: Hjerte-kar-lidelser Behandling af kronisk hyperurikæmi
English: Continue to take ADENURIC every day even when you are not experiencing gout flare or attack.
Danish: Fortsæt med at tage ADENURIC hver dag, selv om De ikke oplever udbrud eller anfald af urinsyregigt.
English: No dose adjustment is required in the elderly (see section 5.2).
Danish: Der kræves ingen dosisjustering hos ældre (se pkt.
English: Concomitant ingestion of an antacid containing magnesium hydroxide and aluminium hydroxide has been shown to delay absorption of febuxostat (approximately 1 hour) and to cause a 32% decrease in Cmax, but no significant change in AUC was observed.
Danish: Samtidig indtagelse af antacida, der indeholder magnesiumhydroxid og aluminiumhydroxid, har vist sig at forsinke absorptionen af febuxostat (cirka én time) og at medføre en 32 % nedsættelse i Cmax, men der blev ikke observeret nogen signifikant ændring i AUC.
English: • severe swelling of the deeper layers of the skin, especially around the lips, eyes, genitals, hands, feet or tongue, with possible sudden difficult breathing
Danish: • svære hævelser i de dybere lag af huden, især omkring læber, øjne, kønsorganer, hænder, fødder eller tunge, muligvis sammen med pludseligt vejrtrækningsbesvær
English: Clinical Outcomes: proportion of patients requiring treatment for a gout flare
Danish: Kliniske resultater: andelen af patienter der krævede behandling for et udbrud af arthritis urica
English: Do not give this medicine to children under the age of 18 because the safety and efficacy have not been established.
Danish: Giv ikke ADENURIC til børn under 18 år, da sikkerhed og virkning endnu ikke er klarlagt hos denne aldersgruppe.
English: There were no significant changes observed in AUC of febuxostat or its metabolites following multiple oral doses of ADENURIC in elderly as compared to younger healthy subjects.
Danish: Der blev ikke observeret væsentlige ændringer i febuxostats eller dets metabolitters AUC efter gentagne orale doser af ADENURIC hos ældre sammenlignet med hos yngre, raske forsøgspersoner.
English: Opadry II, Yellow, 85F42129 containing: Polyvinyl alcohol
Danish: Opadry II, gul, 85F42129 indeholdende: Polyvinylalkohol
English: Talk to your doctor before taking ADENURIC:
Danish: Kontakt lægen, før De tager ADENURIC:
English: Three years data showed a decrease in the incidence of gout flares with less than 4% of patients requiring treatment for a flare (i.e. more than 96% of patients did not require treatment for a flare) at Month 16-24 and at Month 30-36.
Danish: Treårs data viste et fald i forekomsten af udbrud af arthritis urica, hvor mindre end 4 % af patienterne krævede behandling for et udbrud (dvs. mere end 96 % af patienterne behøvede ikke behandling for et udbrud) ved måned 16-24 og ved måned 30-36.
English: Keeping uric acid levels low by taking ADENURIC once every day stops crystals building up, and over time it reduces symptoms.
Danish: Når niveauet af urinsyre holdes lavt ved brug af ADENURIC én gang om dagen, standser opbygningen af krystaller, og efterhånden mindskes symptomerne.
English: Population pharmacokinetic/pharmacodynamic analyses were conducted in 211 patients with hyperuricaemia and gout, treated with ADENURIC 40-240 mg QD.
Danish: Der blev gennemført populationsfarmakokinetiske/-farmakodynamiske analyser hos 211 patienter med hyperurikæmi og arthritis urica, som blev behandlet med ADENURIC 40-240 mg en gang dagligt.
English: At least 65% of the patients had mild-moderate renal impairment (with creatinine clearance of 30-89 mL/min).
Danish: Mindst 65 % af patienterne havde let til moderat nedsat nyrefunktion (kreatininclearance 3089 ml/min).
English: Patheon France 40 Boulevard de Champaret FR-38300 Bourgoin Jallieu France or
Danish: Patheon France 40 Boulevard de Champaret FR-38300 Bourgoin Jallieu Frankrig eller
English: Thus, ADENURIC may be taken without regard to food.
Danish: ADENURIC kan derfor tages uden hensyntagen til fødeindtagelse.
English: ADENURIC 120 mg tablets is also used to treat and prevent high blood levels of uric acid that may occur when you start to receive chemotherapy for blood cancers.
Danish: ADENURIC 120 mg tabletter anvendes også til at behandle og forebygge forhøjet indhold af urinsyre i blodet, som kan forekomme, når De begynder at få kemoterapi mod blodkræft.
English: Primary endpoint in the sub-group of patients with renal impairment
Danish: Primært endepunkt i undergruppen af patienter med nedsat nyrefunktion
English: It is especially important to tell your doctor or pharmacist if you are taking medicines containing any of the following substances as they may interact with ADENURIC and your doctor may wish to consider necessary measures:
Danish: Det er særlig vigtigt, at De fortæller det til Deres læge, hvis De tager lægemidler, der indeholder et eller flere af følgende stoffer, da sådanne lægemidler og ADENURIC kan påvirke hinanden.
English: There were no clinically significant differences in the percent decrease in serum uric acid concentration in healthy subjects irrespective of their renal function (58% in the normal renal function group and 55% in the severe renal dysfunction group).
Danish: Der var ingen klinisk signifikante forskelle i det procentmæssige fald i koncentrationen af serumurinsyre hos raske forsøgspersoner uanset deres nyrefunktion (58 % i gruppen med normal nyrefunktion og 55 % i gruppen med svært nedsat nyrefunktion).
English: Table 1: Adverse reactions in combined phase 3, long-term extension studies and post-marketing experience
Danish: Tabel 1: Bivirkninger i kombinerede langvarige fase 3- forlængelsesstudier og efter markedsføringen
English: ADENURIC is for adults.
Danish: ADENURIC anvendes til voksne.
English: Desipramine/CYP2D6 substrates
Danish: Desipramin/CYP2D6-substrater.
English: No patients with organ transplant have been included in these studies (see section
Danish: Der blev ikke rekrutteret organtransplanterede patienter til disse studier (se pkt.
English: In the FLORENCE study ADENURIC demonstrated a superior control of serum uric acid level compared to allopurinol in patients scheduled to receive the latter drug.
Danish: I FLORENCE-studiet viste ADENURIC en superior kontrol af serumurinsyreniveauet sammenlignet med allopurinol hos patienter, som var planlagt til at skulle have sidstnævnte lægemiddel.
English: Between 46% and 55% of subjects received treatment for gout flares from Week 8 and Week 28.
Danish: Mellem 46 % og 55 % af deltagerne blev behandlet for udbrud af arthritis urica mellem uge 8 og uge 28.
English: • rash (including various types of rash, please see below under “uncommon” and “rare” sections)
Danish: • udslæt (herunder forskellige typer udslæt - se nedenfor under 'ikke almindelige bivirkninger' og
English: In each phase 3 pivotal study, ADENURIC demonstrated superior ability to lower and maintain serum uric acid levels compared to allopurinol.
Danish: I alle pivotale fase 3-studier påviste ADENURIC superior evne til at sænke og vedligeholde serumurinsyreniveauer sammenlignet med allopurinol.
English: Should you experience allergic reactions to ADENURIC, stop taking this medicine (see also section 4).
Danish: Hold op med at tage medicinen, hvis De får allergiske reaktioner på ADENURIC (se også punkt 4).
English: ADENURIC tablets contain lactose (a type of sugar).
Danish: ADENURIC tabletter indeholder laktose (en sukkerart).
English: For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.
Danish: Hvis De vil have yderligere oplysninger om ADENURIC, skal De henvende Dem til den lokale repræsentant for indehaveren af markedsføringstilladelsen.
English: 46% and 38%, of patients on final stable treatment of febuxostat 80 or 120 mg QD, respectively, had complete resolution of the primary palpable tophus from baseline to the Final Visit.
Danish: Hos 46 % og 38 % af patienterne i endelig stabil behandling med henholdsvis febuxostat 80 og 120 mg en gang dagligt, forsvandt den primære palpable tophus fuldstændigt fra baseline og til det sidste besøg.
English: If serum uric acid is > 6 mg/dL (357 µmol/L) after 2-4 weeks, ADENURIC 120 mg once daily may be considered.
Danish: Hvis serumurinsyre er > 357 µmol/l (6 mg/dl) efter 2-4 uger, bør det overvejes at give ADENURIC 120 mg én gang dagligt.
English: • Do not use this medicine after the expiry date which is stated on the carton and the tablet blister foil after ‘EXP.'
Danish: • Brug ikke lægemidlet efter den udløbsdato, der står på pakningen.
English: Following multiple oral 80 mg once daily doses or a single 120 mg dose with a high fat meal, there was a 49% and 38% decrease in Cmax and a 18% and 16% decrease in AUC, respectively.
Danish: Efter gentagne orale doser på 80 mg én gang dagligt eller en enkelt dosis på 120 mg sammen med et meget fedtholdigt måltid var der et fald på henholdsvis 49 % og 38 % i Cmax og et fald på henholdsvis 18 % og 16 % i AUC.
English: The ability of ADENURIC to lower serum uric acid levels was prompt and persistent.
Danish: ADENURICs evne til at sænke serumurinsyreniveauerne var hurtig og vedvarende.
English: In the randomized, double-blind, Phase 3 pivotal FLORENCE (FLO-01) study comparing febuxostat with allopurinol (346 patients undergoing chemotherapy for haematologic malignancies and at intermediate-to-high risk of TLS), only 22 (6.4%) patients overall experienced adverse reactions, namely 11 (6.4%) patients in each treatment group.
Danish: I det randomiserede, dobbeltblindede, pivotale fase 3-studie FLORENCE (FLO-01), der sammenlignede febuxostat med allopurinol (346 patienter i kemoterapi for hæmatologiske maligniteter og en middel til høj risiko for tumorlyse-syndrom), fik kun 22 (6,4 %) patienter bivirkninger, nemlig 11 (6,4 %) patienter i hver behandlingsgruppe.
English: Patheon France 40 boulevard de Champaret 38300 Bourgoin Jallieu France or
Danish: 40 boulevard de Champaret 38300 Bourgoin Jallieu Frankrig eller
English: • If you are allergic to febuxostat or any of the other ingredients of this medicine (listed in section
Danish: • hvis De er allergisk over for febuxostat eller et af de øvrige indholdsstoffer i ADENURIC (angivet i punkt 6).
English: Mean (±SEM) Serum Uric Acid Level (mg/dL)
Danish: Middel (±SEM) serumurinsyreniveau (mg/dL)
English: Clear (Aclar/PVC/Aluminium or PVC/PE/PVDC/Aluminium) blister of 14 tablets.
Danish: Klare (aclar/PVC/aluminium eller PVC/PE/PVDC/aluminium) blisterkort med 14 tabletter.
English: Overall, 346 patients with haematological malignancies undergoing chemotherapy and at intermediate / high risk of Tumor Lysis Syndrome were included.
Danish: I alt deltog 346 patienter, der var i kemoterapi for hæmatologiske maligniteter og havde en middel/høj risiko for tumorlyse-syndrom.
English: Febuxostat is a 2-arylthiazole derivative that achieves its therapeutic effect of decreasing serum uric acid by selectively inhibiting XO. Febuxostat is a potent, non-purine selective inhibitor of XO (NP-SIXO) with an in vitro inhibition Ki value less than one nanomolar.
Danish: Febuxostat er et 2-arylthiazolderivat, der opnår terapeutiske effekt i form af nedsættelse af serumurinsyren ved selektivt at hæmme XO. Febuxostat er en potent, ikke-purin selektiv XO-hæmmer (non-purine selective inhibitor of XO (NP-SIXO)) med en Ki-værdi for in vitroinhibering, der er mindre end én nanomolær.
English: • hot flushes or flushing (e.g. redness of the face or neck), increased blood pressure, bleeding (hemorrhage, seen only in patients taking chemotherapy for blood disorders)
Danish: • hedeture eller flushing (rødme i ansigt eller på hals), forhøjet blodtryk, blødning (kun hos patienter, der er i kemoterapi mod blodsygdomme)
English: Drug interaction studies of febuxostat with drugs (except theophylline) that are metabolized by XO have not been performed in humans.
Danish: Der er ikke udført interaktionstudier mellem febuxostat og lægemidler (undtagen theophyllin), der metaboliseres af XO, hos mennesker.
English: ADENURIC 80 mg and 120 mg is packed in clear (Aclar/PVC/Aluminium or PVC/PE/PVDC/Aluminium) blister of 14 tablets.
Danish: ADENURIC 80 mg og 120 mg pakkes i klare (aclar/PVC/aluminium eller PVC/PE/PVDC/aluminium) blisterkort med 14 tabletter.
English: Uric acid is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine → xanthine → uric acid.
Danish: Urinsyre er slutproduktet af purinmetabolismen hos mennesker, og den genereres i følgende trin: hypoxanthin  xanthin  urinsyre.
English: After single or multiple oral 80 and 120 mg once daily doses, Cmax is approximately 2.8-3.2 µg/mL, and 5.0-5.3 µg/mL, respectively.
Danish: Efter enkelte eller gentagne orale doser på 80 og 120 mg én gang dagligt er Cmax henholdsvis cirka 2,8-3,2 mikrog/ml og 5,05,3 mikrog/ml.
English: Each tablet contains 76.50 mg of lactose (as monohydrate)
Danish: Hver tablet indeholder 76,50 mg lactose (som monohydrat).
English: Prevention and treatment of high uric acid levels in patients undergoing cancer chemotherapy
Danish: Forebyggelse og behandling af høje urinsyreniveauer hos patienter i kemoterapi mod kræft
English: In addition to the urinary excretion, approximately 45% of the dose was recovered in the faeces as the unchanged febuxostat (12%), the acyl glucuronide of the active substance (1%), its known oxidative metabolites and their conjugates (25%), and other unknown metabolites (7%).
Danish: Foruden renal udskillelse blev cirka 45 % af dosis genfundet i fæces som uændret febuxostat (12 %), det aktive stofs acyl-glukuronid (1 %), dets kendte oxidative metabolitter og deres konjugater (25%) samt andre ukendte metabolitter (7 %).
English: Each tablet contains 114.75 mg of lactose (as monohydrate)
Danish: Hver tablet indeholder 114,75 mg lactose (som monohydrat).
English: ADENURIC film-coated tablets are pale yellow to yellow in colour and capsule shaped.
Danish: ADENURIC filmovertrukne tabletter er lysegule til gule, kapselformede tabletter.
English: The 120 mg film-coated tablets are marked on one side with ‘120'.
Danish: 120 mg filmovertrukne tabletter er præget med ‘120' på den ene side.
English: ADENURIC contains lactose
Danish: ADENURIC indeholder laktose
English: In the additional phase 3 CONFIRMS study, for which results became available after the marketing authorisation for ADENURIC was first issued, the primary efficacy endpoint was the proportion of patients whose serum urate level was < 6.0 mg/dL at the final visit.
Danish: I det supplerende fase 3-studie CONFIRMS, hvis resultater blev offentliggjort efter den første udstedelse af markedsføringstilladelse for ADENURIC, var det primære effektmål andelen af patienter med serumurat < 357 µmol/l (6,0 mg/dl) ved det sidste besøg.
English: Somnolence, dizziness, paraesthesia and blurred vision have been reported with the use of Febuxostat.
Danish: Der er rapporteret døsighed, svimmelhed, paræstesi og uskarpt syn i forbindelse med anvendelse af febuxostat.
English: In healthy subjects concomitant use of febuxostat and naproxen 250 mg twice daily was associated with an increase in febuxostat exposure (Cmax 28%, AUC 41% and t1/2 26%).
Danish: Hos raske forsøgspersoner blev samtidig brug af febuxostat og naproxen 250 mg to gange dagligt associeret med en stigning i febuxostat-eksponeringen (Cmax 28 %, AUC 41 % og t1/2 26 %).
English: ADENURIC works sufficiently quickly to allow retesting of the serum uric acid after 2 weeks.
Danish: ADENURIC virker tilstrækkelig hurtigt til, at serumurinsyren kan testes igen efter to uger.
English: ADENURIC showed a superior and faster urate lowering activity compared to allopurinol.
Danish: ADENURIC viste en superior og hurtigere evne til at sænke uratniveauet sammenlignet med allopurinol.
English: The effect of ADENURIC on human fertility is unknown.
Danish: Det er ukendt, om ADENURIC påvirker human fertilitet.
English: 62% of patients required no dose adjustment to maintain sUA <6 mg/dL and 38% of patients required a dose adjustment to achieve a final stable dose.
Danish: 62 % af patienterne behøvede ikke dosisjustering for at opretholde et serumurinsyreniveau < 357 µmol/l (6 mg/dl), mens 38 % af patienterne havde behov for dosisjustering for at opnå en endelig stabil dosis.
English: ADENURIC is indicated in adults.
Danish: ADENURIC er indiceret til behandling af voksne.
English: ADENURIC is indicated for the prevention and treatment of hyperuricaemia in adult patients undergoing chemotherapy for haematologic malignancies at intermediate to high risk of Tumor Lysis Syndrome (TLS).
Danish: ADENURIC er indikeret til forebyggelse og behandling af hyperurikæmi hos voksne patienter i behandling med kemoterapi for hæmatologiske maligniteter med en middel til høj risiko for tumorlyse-syndrom.
English: The efficacy of ADENURIC was demonstrated in three Phase 3 pivotal studies (the two pivotal APEX and FACT studies, and the additional CONFIRMS study described below) that were conducted in 4101 patients with hyperuricaemia and gout.
Danish: Virkningen af ADENURIC blev påvist i tre pivotale fase 3-studier (de to pivotale studier APEX og FACT og det supplerende CONFIRMS-studie beskrevet nedenfor), der blev gennemført med 4.101 patienter med hyperurikæmi og arthritis urica.
English: FLORENCE was a randomized (1:1), double blind, phase III, pivotal trial comparing ADENURIC 120 mg once daily with allopurinol 200 to 600 mg daily (mean allopurinol daily dose [± standard deviation]: 349.7 ± 112.90 mg) in terms of control of serum uric acid level.
Danish: FLORENCE var et randomiseret (1:1), dobbeltblindet, pivotalt fase 3-studie, der sammenlignede ADENURIC 120 mg en gang dagligt med allopurinol 200 til 600 mg dagligt (daglig gennemsnitsdosis allopurinol (± standard afvigelse): 349,7 ± 112,90 mg) i forhold til kontrol af serumurinsyreniveau.
English: In patients with very high urate levels (e.g. those undergoing cancer chemotherapy), treatment with uric acid-lowering medicines could lead to the build-up of xanthine in the urinary tract, with possible stones, even though this has not been observed in patients being treated with ADENURIC for Tumor Lysis Syndrome.
Danish: Hos patienter, hvis urinsyreniveau er meget højt (f.eks. hvis man er i kemobehandling), kan behandling med urinsyresænkende medicin medføre, at der ophobes xanthin i urinvejene, evt. med dannelse af nyresten, selvom dette ikke er blevet observeret hos patienter, der behandles med ADENURIC mod tumorlyse-syndrom.
English: Hepatitis, jaundice*, liver injury*
Danish: Hepatitis, ikterus*, leverskader*
English: ADENURIC is indicated for the treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis).
Danish: ADENURIC er indikeret til behandling af kronisk hyperurikæmi, hvor der allerede er urataflejringer (herunder en anamnese med eller tilstedeværelse af tophi og/eller arthritis urica).
English: Pale yellow to yellow, film-coated, capsule shaped tablets, engraved with “120” on one side
Danish: Lysegule til gule, filmovertrukne, kapselformede tabletter, præget med “120” på den ene side.
English: The mean total AUC of febuxostat increased by approximately 1.8-fold from 7.5 µg⋅h/mL in the normal renal function group to 13.2 µg.h/mL in the severe renal dysfunction group.
Danish: Febuxostats gennemsnitlige totale AUC steg cirka 1,8 gange fra 7,5 gtime/ml hos gruppen med normal nyrefunktion til 13,2 gtime/ml hos gruppen med svært nedsat nyrefunktion.
English: Following multiple doses of 80 mg of ADENURIC in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment, the Cmax and AUC of febuxostat and its metabolites did not change significantly compared to subjects with normal hepatic function.
Danish: Efter gentagne doser på 80 mg ADENURIC hos patienter med let (Child-Pugh klasse A) eller moderat (Child-Pugh klasse B) nedsat leverfunktion ændredes Cmax og AUC for febuxostat og dets metabolitter ikke signifikant sammenlignet med forsøgspersoner med normal leverfunktion.
English: In a study in healthy subjects, 120 mg ADENURIC QD resulted in a mean 22% increase in AUC of desipramine, a CYP2D6 substrate indicating a potential weak inhibitory effect of febuxostat on the CYP2D6 enzyme in vivo.
Danish: I en studie med raske forsøgspersoner resulterede 120 mg ADENURIC en gang dagligt i en gennemsnitlig stigning på 22 % i AUC for desipramin, et CYP2D6-substrat, hvilket indikerer, at febuxostat har en potentiel, svag hæmmende virkning på CYP2D6-enzymet in vivo.
English: Other medicines and ADENURIC
Danish: Brug af anden medicin sammen med ADENURIC
English: Lactose monohydrate Microcrystalline cellulose Magnesium stearate Hydroxypropylcellulose Croscarmellose sodium Silica, colloidal hydrated
Danish: Lactosemonohydrat Mikrokrystallinsk cellulose Magnesiumstearat Hydroxypropylcellulose Croscarmellosenatrium Kolloid silica