FrancophonIA/ELRC3.0 huggingface dataset:
English: If this applies to you, tell your doctor immediately and do not take Tenofovir disoproxil Zentiva.
Slovenian: Če to velja za vas, o tem nemudoma obvestite zdravnika in ne jemljite zdravila Dizoproksiltenofovirat Zentiva.
English: From both the genotypic and phenotypic analyses there was no evidence for other pathways of resistance to tenofovir.
Slovenian: Niti genotipske niti fenotipske analize niso podale dokazov za druge poti razvoja rezistence na tenofovir.
English: Overall, the data derived from this study are too limited to draw any definitive conclusions on the comparison of emtricitabine plus tenofovir disoproxil versus tenofovir disoproxil, (see Table 7 below).
Slovenian: V splošnem so podatki, izpeljani iz te študije, preveč omejeni, da bi iz njih lahko potegnili dokončne zaključke o primerjavi emtricitabina in dizoproksiltenofovirata z dizoproksiltenofoviratom (glejte spodnjo preglednico 7).
English: increased transaminases
Slovenian: povišane vrednosti transaminaz
English: Table 7: Safety and efficacy parameters in decompensated patients at week 48
Slovenian: Preglednica 7: Parametri varnosti in učinkovitosti pri dekompenziranih bolnikih v 48. tednu zdravljenja
English: Reproductive studies in rats and rabbits showed no effects on mating, fertility, pregnancy or foetal parameters.
Slovenian: Študije o vplivu na sposobnost razmnoževanja na podganah in zajcih niso pokazale učinkov na parjenje, plodnost, nosečnost ali plod.
English: If you are older than this and are prescribed Tenofovir disoproxil Zentiva, your doctor will monitor you carefully.
Slovenian: Če ste starejši in so vam predpisali zdravilo Dizoproksiltenofovirat Zentiva, vas bo zdravnik skrbno nadzoroval.
English: • If you are allergic to tenofovir, tenofovir disoproxil phosphate or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • Če ste alergični na tenofovir, dizoproksiltenofovirijev fosfat ali katero koli sestavino tega zdravila, navedeno v poglavju 6.
English: The frequency category was estimated from a statistical calculation based on the total number of patients exposed to tenofovir disoproxil in randomised controlled clinical trials and the expanded access program (n = 7,319).
Slovenian: Kategorija pogostnosti je bila ocenjena s statističnim izračunom na podlagi skupnega števila bolnikov, izpostavljenih dizoproksiltenofoviratu v randomiziranih kontroliranih kliničnih študijah in podaljšanem programa dostopanja (n = 7.319).
English: Comparisons between treatment groups beyond week 24 are difficult to interpret since investigators had the option to intensify treatment to open-label emtricitabine plus tenofovir disoproxil.
Slovenian: Primerjave med skupinami zdravljenja po 24. tednu je bilo težko razlagati, ker so imeli raziskovalci na voljo možnost stopnjevati zdravljenje v nezaslepljeno zdravljenje z emtricitabinom in dizoproksiltenofoviratom.
English: If you feel dizzy while taking Tenofovir disoproxil Zentiva, do not drive or ride a bicycle and do not use any tools or machines.
Slovenian: Če ste v času zdravljenja z zdravilom Dizoproksiltenofovirat Zentiva omotični, ne vozite avtomobila ali kolesa in ne upravljajte z orodji ali stroji.
English: If you have a history of liver disease or chronic hepatitis B infection your doctor may conduct blood tests to monitor your liver function.
Slovenian: Če ste imeli jetrne bolezni ali imate okužbo s kroničnim hepatitisom B, bo vaš zdravnik morda opravil krvne preiskave za nadzorovanje jetrne funkcije.
English: Severe renal impairment: 245 mg tenofovir disoproxil may be administered every 72 - 96 hours (dosing twice a week).
Slovenian: Huda ledvična okvara: 245 mg dizoproksiltenofovirata se lahko daje vsakih 72-96 ur (odmerjanje dvakrat na teden).
English: • If you have HBV your doctor may offer you an HIV test to see if you have both HBV and HIV.
Slovenian: • Če ste okuženi z virusom HBV, vam bo zdravnik morda ponudil preskus okužbe z virusom HIV, da vidi, ali ste morda okuženi z virusoma HBV in HIV.
English: At weeks 96, 144, 192, 240, 288 and 384, viral suppression, biochemical and serological responses were maintained with continued tenofovir disoproxil treatment (see Tables 4 and 5 below).
Slovenian: V 96., 144., 192., 240., 288. in 384. tednu so bili virusna supresija ter biokemični in serološki odzivi ohranjeni pri neprekinjenem zdravljenju z dizoproksiltenofoviratom (glejte preglednici 4 in 5 spodaj).
English: Renal function (creatinine clearance and serum phosphate) should be evaluated prior to treatment, and monitored during treatment as in adults (see above).
Slovenian: Ledvično funkcijo (očistek kreatinina in koncentracija serumskega fosfata) je treba pred zdravljenjem ovrednotiti in med zdravljenjem nadzorovati kot pri odraslih (glejte zgoraj).
English: Stopping treatment with Tenofovir disoproxil Zentiva may reduce the effectiveness of the treatment recommended by your doctor.
Slovenian: Prenehanje zdravljenja z zdravilom Dizoproksiltenofovirat Zentiva lahko zmanjša učinkovitost zdravljenja, ki vam ga je predpisal zdravnik.
English: Possible serious side effects: tell your doctor immediately Lactic acidosis (excess lactic acid in the blood) is a rare (may affect up to 1 in 1,000 people) but serious side effect that can be fatal.
Slovenian: Možni resni neželeni učinki: nemudoma se posvetujte s svojim zdravnikom Laktacidoza (povečana količina mlečne kisline v krvi) je redek (prizadene lahko do 1 od 1.000 bolnikov), a resen neželeni učinek, ki je lahko usoden.
English: • Not for HIV-1 infected children under 12 years of age.
Slovenian: • ni za otroke, okužene s HIV-1, mlajše od 12 let;
English: increased creatinine, proximal renal tubulopathy (including Fanconi syndrome)
Slovenian: povišan kreatinin, proksimalna ledvična tubulopatija (vključno s Fanconijevim sindromom)
English: If you notice any of these symptoms tell your doctor.
Slovenian: Če opazite katerega od teh simptomov, obvestite zdravnika.
English: Seven patients had estimated glomerular filtration rate (GFR) values between 70 and 90 ml/min/1.73 m2.
Slovenian: Sedem bolnikov je imelo ocenjen nivo hitrosti glomerularne filtracije (GFR) med 70 in 90 ml/min/1,73 m2.
English: Medicinal product by therapeutic areas (dose in mg)
Slovenian: Učinkovine po terapevtskih področjih (odmerek v mg)
English: Do not use this medicine after the expiry date which is stated on the bottle and carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na plastenki in škatli poleg oznake {Uporabno do}.
English: Excipient with known effect: Each tablet contains 214.5 mg lactose monohydrate.
Slovenian: Pomožna snov z znanim učinkom: Ena tableta vsebuje 214,5 mg laktoze monohidrata.
English: The following side effects may be signs of lactic acidosis:
Slovenian: Naslednji neželeni učinki so lahko znaki laktacidoze:
English: 3 Study conducted with additional voxilaprevir 100 mg to achieve voxilaprevir exposures expected in HCV-infected patients.
Slovenian: Študijo so izvedli z dodatnim voksilaprevirjem 100 mg za doseganje izpostavljenosti voksilaprevirju, ki se pričakuje pri bolnikih z okužbo s HCV.
English: If no alternative treatment is available, prolonged dose intervals using the 245 mg film-coated tablets may be used as follows:
Slovenian: Če ni na voljo alternativne oblike zdravljenja, se lahko uporabijo podaljšani odmerni intervali z 245-miligramskimi filmsko obloženimi tabletami, kot sledi:
English: • Other medicines containing didanosine (for HIV infection): Taking Tenofovir disoproxil Zentiva with other antiviral medicines that contain didanosine can raise the levels of didanosine in your blood and may reduce CD4 cell counts.
Slovenian: • Druga zdravila, ki vsebujejo didanozin (za okužbe z virusom HIV): Jemanje zdravila Dizoproksiltenofovirat Zentiva skupaj z drugimi protivirusnimi zdravili, ki vsebujejo didanozin, lahko zviša ravni didanozina v krvi in zmanjša število celic CD4.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Slovenian: Opisani so bili primeri osteonekroze, še zlasti pri bolnikih s splošno znanimi dejavniki tveganja, napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo CART.
English: The K65R mutation occurred in a slightly higher percentage of patients in the tenofovir disoproxil group than the active control group (2.7% versus 0.7%).
Slovenian: Mutacija K65R se je pojavila pri bolnikih v dizoproksiltenofoviratni skupini v rahlo zvišanem odstotku kot pri aktivni kontrolni skupini (2,7% napram 0,7%).
English: Simulations suggest that the prolonged dose interval using Tenofovir disoproxil Zentiva 245 mg film-coated tablets is not optimal and could result in increased toxicity and possibly inadequate response.
Slovenian: Simulacije nakazujejo, da podaljšani odmerni interval z zdravilom Dizoproksiltenofovirat Zentiva 245 mg filmsko obložene tablete ni optimalen in lahko vodi v povečano toksičnost in možnost nezadostnega odziva.
English: • HIV-1 infected adolescents aged 12 to less than 18 years who weigh at least 35 kg and who have already been treated with other HIV medicines which are no longer fully effective due to development of resistance, or have caused side effects
Slovenian: • mladostnike, okužene s HIV-1, stare 12 do manj kot 18 let, s telesno maso vsaj 35 kg, ki so se predhodno že zdravili z drugimi zdravili proti HIV, ki niso več polno učinkovita zaradi nastanka odpornosti ali so povzročala neželene učinke;
English: However, tenofovir disoproxil reduced the viability index and weight of pups in peri-postnatal toxicity studies at maternally toxic doses.
Slovenian: Vendar pa je dizoproksiltenofoviriat zmanjšal indeks življenjskih funkcij in težo mladičkov v peri- in postnatalnih študijah toksičnosti pri odmerkih, toksičnih za mater.
English: Do not reduce the prescribed dose, unless your doctor has told you to do so.
Slovenian: Predpisanega odmerka ne zmanjšajte, če vam tega ne naroči vaš zdravnik.
English: This active substance is an antiretroviral or antiviral medicine which is used to treat HIV or HBV infection or both.
Slovenian: Ta učinkovina je protiretrovirusno ali protivirusno zdravilo, ki se uporablja za zdravljenje okužbe z virusom HIV, okužbe z virusom HBV ali obeh.
English: The difference in the proportion of patients who maintained < 400 copies/ml at week 48 was mainly influenced by the higher number of discontinuations in the tenofovir disoproxil treatment group.
Slovenian: Na razliko v deležu bolnikov, ki so ohranili < 400 kopij/ml v 48. tednu, je v glavnem vplivalo večje število prekinitev v skupini zdravljenja z dizoproksiltenofoviratom.
English: Administration of tenofovir disoproxil with a high fat meal enhanced the oral bioavailability, with an increase in tenofovir AUC by approximately 40% and Cmax by approximately 14%.
Slovenian: Jemanje dizoproksiltenofovirata z maščobami bogatim obrokom je povečalo peroralno biološko razpoložljivost s povečanjem AUC tenofovirja za približno 40% in Cmax za približno 14%.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, odsotnostjo encima laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: Following intravenous administration the steady-state volume of distribution of tenofovir was estimated to be approximately 800 ml/kg.
Slovenian: Po intravenoznem odmerku je volumen porazdelitve tenofovirja v stanju dinamičnega ravnotežja znašal po ocenah približno 800 ml/kg.
English: If overdose occurs the patient must be monitored for evidence of toxicity (see sections 4.8 and 5.3), and standard supportive treatment applied as necessary.
Slovenian: V primeru prevelikega odmerka je potrebno pri bolniku nadzorovati znake toksičnosti (glejte poglavji 4.8 in 5.3) in mu nuditi standardno podporno zdravljenje.
English: The bottle contains 30 film-coated tablets and a silica gel desiccant (in a container).
Slovenian: Plastenka vsebuje 30 filmsko obloženih tablet in silikagelsko sušilno sredstvo (v vsebniku).
English: Efavirenz or lamivudine resistance either preceded or was coincident with the development of K65R in all cases.
Slovenian: V vseh primerih je bila rezistenca na efavirenz oziroma lamivudin ali predhodno obstoječa ali pa sočasna z razvojem K65R.
English: In other studies (prospective and cross-sectional), the most pronounced decreases in BMD were seen in patients treated with tenofovir disoproxil as part of a regimen containing a boosted protease inhibitor.
Slovenian: V drugih študijah (prospektivne in presečne) so najbolj izrazito zmanjšanje MGK opazili pri bolnikih, zdravljenih z dizoproksiltenofoviratom kot del režima, ki je vseboval okrepljen zaviralec proteaze.
English: Interactions between tenofovir disoproxil and other medicinal products are listed in Table 1 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, twice daily as “b.i.d.”, and once daily as “q.d.”).
Slovenian: Interakcije med dizoproksiltenofoviratom in drugimi zdravili so navedene v preglednici 1 spodaj (povečanje je označeno z znakom “↑”, zmanjšanje z “↓”, brez spremembe z “↔”, dvakrat na dan z “b.i.d.”, enkrat na dan pa s “q.d.”).
English: If you miss a dose of Tenofovir disoproxil Zentiva, work out how long since you should have taken it.
Slovenian: Če ste izpustili odmerek zdravila Dizoproksiltenofovirat Zentiva, izračunajte, koliko časa je minilo od takrat, ko bi ga morali vzeti.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with tenofovir disoproxil in one or more subsets of the paediatric population in HIV and chronic hepatitis B (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Dizoproksiltenofovirat za eno ali več podskupin pediatrične populacije za virus HIV in kronični hepatitis B (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Patients with liver disease including chronic hepatitis B or C, who are treated with antiretrovirals, have a higher risk of severe and potentially fatal liver complications.
Slovenian: Pri bolnikih z jetrnimi boleznimi, vključno s kroničnim hepatitisom B ali C, ki se zdravijo s protiretrovirusnimi zdravili, obstaja povečano tveganje za pojav hudih in potencialno usodnih zapletov.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/16/1127/001
Slovenian: ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET Z ZDRAVILOM EU/1/16/1127/001
English: • HIV adolescent educational brochure • HBV adolescent educational brochure
Slovenian: • izobraževalno gradivo o mladostnikih s HIV • izobraževalno gradivo o mladostnikih s HBV
English: There is insufficient information on the effects of tenofovir in newborns/infants.
Slovenian: Podatki o učinku tenofovirja na dojene novorojence/otroke so nezadostni.
English: If you think that you may have any of these serious side effects, talk to your doctor.
Slovenian: Če menite, da bi lahko imeli katerega koli od teh resnih neželenih učinkov, se posvetujte s svojim zdravnikom.
English: Look out for signs of inflammation or infection soon after you start taking Tenofovir disoproxil Zentiva.
Slovenian: Bodite pozorni na simptome vnetja ali okužbe kmalu po začetku jemanja zdravila Dizoproksiltenofovirat Zentiva.
English: Entecavir (0.5 mg or 1 mg) n = 22
Slovenian: entekavir (0,5 mg ali 1 mg) n = 22
English: ALT elevations had a median time to onset of 8 weeks, resolved with continued treatment, and, in a majority of cases, were associated with a ≥ 2 log10 copies/ml reduction in viral load that preceded or coincided with the ALT elevation.
Slovenian: Mediana časa do zvišanja ALT med zdravljenjem je bila 8 tednov, zvišanje se je ob neprekinjenem zdravljenju prenehalo, v večini primerov pa je bilo povezano z zmanjšanjem virusne obremenitve za ≥ 2 log10 kopij/ml, ki se je zgodilo pred zvišanjem ALT ali pa je sovpadalo z njim.
English: Tenofovir is primarily excreted by the kidney by both filtration and an active tubular transport system with approximately 70 - 80% of the dose excreted unchanged in urine following intravenous administration.
Slovenian: Tenofovir se primarno izloča preko ledvic tako s filtracijo kot z aktivnim tubularnim transportnim sistemom, pri čemer se po intravenoznem vnosu približno 70-80% odmerka izloči nespremenjenega s sečem.
English: Some patients have had blood tests or symptoms indicating that their hepatitis has got worse after stopping Tenofovir disoproxil Zentiva.
Slovenian: Krvne preiskave ali simptomi pri nekaterih bolnikih so kazali, da se je njihov hepatitis poslabšal po prenehanju zdravljenja z zdravilom Dizoproksiltenofovirat Zentiva.
English: Appropriate precautions must continue to be used.
Slovenian: Zato morate še naprej uporabljati ustrezne zaščitne ukrepe.
English: Tenofovir disoproxil must be taken with food, as food enhances the bioavailability of tenofovir (see section
Slovenian: Dizoproksiltenofovirat se mora jemati s hrano, kajti hrana poviša biološko razpoložljivost tenofovirja (glejte poglavje 5.2).
English: Data pertaining to HIV
Slovenian: Informacije, ki se nanašajo na virus HIV
English: Therapy should be initiated by a physician experienced in the management of HIV infection and/or treatment of chronic hepatitis B.
Slovenian: Terapijo mora izvajati zdravnik, ki že ima izkušnje z zdravljenjem okužbe z virusom HIV in/ali z zdravljenjem kroničnega hepatitisa B.
English: Histological response a,b a The population used for analysis of histology included only patients with available liver biopsy data (Missing = Excluded) by week 240.
Slovenian: Histološki odziva,b (%) a V populaciji, ki so jo uporabili za histološko analizo, so bili samo bolniki, za katere so bili na voljo podatki o biopsiji jeter (manjkajoči = izključeni) do 240. tedna.
English: Exacerbations of hepatitis during treatment
Slovenian: Poslabšanja hepatitisa med zdravljenjem
English: Effects on drug levels Mean percent change in AUC, Cmax, Cmin
Slovenian: Učinki na koncentracije učinkovin Srednja sprememba AUC, Cmax, Cmin v odstotkih
English: As a general rule, it is recommended that HIV and HBV infected women do not breast-feed their infants in order to avoid transmission of HIV and HBV to the infant.
Slovenian: Splošno priporočljivo je, naj s HIV in HBV okužene ženske ne dojijo, da se prepreči prenos HIV in HBV na dojenčka.
English: Method of administration Tenofovir disoproxil Zentiva tablets should be taken once daily, orally with food.
Slovenian: Način uporabe Tablete Dizoproksiltenofovirat Zentiva se jemljejo enkrat dnevno, peroralno s hrano.
English: - In HBeAg negative patients without cirrhosis, treatment should be administered at least until HBs seroconversion or there is evidence of loss of efficacy.
Slovenian: - Pri HBeAg negativnih bolnikih brez ciroze naj zdravljenje traja najmanj do HBs serološke konverzije ali do dokazane izgube učinkovitosti.
English: Tenofovir shows activity in vitro against HIV-2, with an EC50 of 4.9 µmol/l in MT-4 cells.
Slovenian: Tenofovir kaže in vitro aktivnost proti HIV-2 z EC50 4,9 μmol/l v MT-4 celicah.
English: Age Pharmacokinetic studies have not been performed in the elderly (over 65 years of age).
Slovenian: Starost Farmakokinetične študije niso bile izvedene pri starejših (nad 65 let).
English: Tenofovir is principally eliminated via the kidney.
Slovenian: Tenofovir se v glavnem izloča preko ledvic.
English: Animal studies do not indicate harmful effects of tenofovir disoproxil on fertility.
Slovenian: Študije na živalih ne kažejo škodljivih učinkov dizoproksiltenofovirata na plodnost.
English: Bone toxicity was diagnosed as osteomalacia (monkeys) and reduced bone mineral density (BMD) (rats and dogs).
Slovenian: Toksičen vpliv na kosti je bil diagnosticiran kot osteomalacija (pri opicah) in kot zmanjšana mineralna gostota kosti (MGK) (podgane in psi).
English: The pharmacokinetics of tenofovir in paediatric patients with renal impairment have not been studied.
Slovenian: Farmakokinetike tenofovira pri pediatričnih bolnikih z ledvično okvaro niso preučili.
English: The silica gel desiccant is contained in a separate container and should not be swallowed.
Slovenian: Silikagelsko sušilno sredstvo je v posebni vrečici ali vsebniku, ki ga ne smete zaužiti.
English: • If you are an adult and have problems with your kidneys, your doctor may advise you to take Tenofovir disoproxil Zentiva less frequently.
Slovenian: • Če ste odrasla oseba in imate ledvične težave, vam bo zdravnik morda svetoval, da jemljete zdravilo Dizoproksiltenofovirat Zentiva manj pogosto.
English: It is not considered to be causally associated with tenofovir disoproxil in the absence of this condition.
Slovenian: Ne obravnava se kot občasno povezan z dizoproksiltenofoviratom v odsotnosti tega stanja.
English: The breakdown of muscle, softening of the bones (with bone pain and sometimes resulting in fractures), muscle pain, muscle weakness and decreases in potassium or phosphate in the blood may occur due to damage to kidney tubule cells.
Slovenian: Razpad mišičnega tkiva, mehčanje kosti (z bolečinami v kosteh, včasih tudi zlom), bolečine v mišicah, mišična oslabelost in zmanjšanje količine kalija ali fosfatov v krvi se lahko pojavijo zaradi okvare celic ledvičnih tubulov.
English: Film-coated tablet
Slovenian: Filmsko obložena tableta.
English: Resistance: No HBV mutations associated with tenofovir disoproxil resistance have been identified (see Clinical efficacy and safety).
Slovenian: Rezistenca: Mutacij virusa HBV, povezanih z rezistenco na dizoproksiltenofovirat, niso odkrili (glejte razdelek Klinična učinkovitost in varnost).
English: Although there are limited clinical data on the use of Tenofovir disoproxil Zentiva in pregnant women, it is not usually used unless absolutely necessary.
Slovenian: Čeprav so na voljo nezadostni klinični podatki o uporabi zdravila Dizoproksiltenofovirat Zentiva pri nosečnicah, se zdravila Dizoproksiltenofovirat Zentiva ponavadi ne uporablja, razen če je nujno potrebno.
English: Tenofovir has been shown to be excreted in human milk.
Slovenian: Pokazalo se je, da se tenofovir izloča v materino mleko.
English: abdominal pain, abdominal distension, flatulence
Slovenian: abdominalna bolečina, napenjanje, flatulenca
English: The benefits of long-term virologic suppression with continued therapy must be weighed against the risk of prolonged treatment, including the emergence of resistant hepatitis B virus and the uncertainties as regards the long term impact of bone and renal toxicity (see section 4.4).
Slovenian: Koristi dolgotrajne virološke supresije z nadaljevanjem zdravljenja je treba pretehtati glede na tveganje podaljšanega zdravljenja, vključno s pojavom rezistentnega virusa hepatitisa B in negotovostmi v povezavi z dolgoročnimi toksičnimi učinki na kosti in ledvice (glejte poglavje 4.4).
English: Tenofovir disoproxil Zentiva is available only as 245 mg film-coated tablets, it is not suitable for the use in paediatric patients aged 2 < 12 years.
Slovenian: Zdravilo Dizoproksiltenofovirat Zentiva je na voljo samo v obliki 245 mg filmsko obloženih tablet, zato ni primerno za uporabo pri pediatričnih bolnikih, starih 2 do < 12 let.
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy (CART) and should be monitored according to standard practice.
Slovenian: Bolniki s predobstoječo jetrno disfunkcijo, vključno s kroničnim aktivnim hepatitisom, imajo v času kombinirane protiretrovirusne terapije (CART, combination antiretroviral therapy) več anomalij jetrne funkcije in jih je treba nadzirati v skladu s standardno prakso.