FrancophonIA/ELRC3.0 huggingface dataset:
English: When VELCADE is given together with dexamethasone, you will receive VELCADE intravenously as a 21-day treatment cycle and dexamethasone 40 mg is given orally on days 1, 2, 3, 4, 8, 9, 10 and 11 of the VELCADE 21-day treatment cycle.
Croatian: Kada se VELCADE primjenjuje zajedno s deksametazonom, VELCADE ćete primiti intravenski u ciklusu liječenja koji traje 21 dan, a deksametazon od 40 mg se primjenjuje kroz usta 1., 2., 3., 4., 8., 9., 10. i 11. dana ciklusa liječenja lijekom VELCADE koji traje 21 dan.
English: Combination therapy with pegylated liposomal doxorubicin VELCADE 3.5 mg powder for solution for injection is administered via intravenous or subcutaneous injection at the recommended dose of 1.3 mg/m2 body surface area twice weekly for two weeks on days 1, 4, 8, and 11 in a 21-day treatment cycle.
Croatian: Kombinirano liječenje s pegiliranim liposomalnim doksorubicinom VELCADE 3,5 mg prašak za otopinu za injekciju primjenjuje se putem intravenske ili supkutane injekcije u preporučenoj dozi od 1,3 mg/m2 površine tijela, dva puta tjedno tijekom dva tjedna, 1., 4., 8. i 11. dana, u ciklusu liječenja od 21 dan.
English: Combination therapy with pegylated liposomal doxorubicin VELCADE 1 mg powder for solution for injection is administered via intravenous injection at the recommended dose of 1.3 mg/m2 body surface area twice weekly for two weeks on days 1, 4, 8, and 11 in a 21-day treatment cycle.
Croatian: Kombinirano liječenje s pegiliranim liposomalnim doksorubicinom VELCADE 1 mg prašak za otopinu za injekciju primjenjuje se putem intravenske injekcije u preporučenoj dozi od 1,3 mg/m2 površine tijela, dva puta tjedno tijekom dva tjedna, 1., 4., 8. i 11. dana, u ciklusu liječenja od 21 dan.
English: • Benign cysts
Croatian: • žučni kamenci
English: VELCADE 1 mg powder for solution for injection is administered via intravenous injection at the recommended dose of 1.3 mg/m2 body surface area twice weekly for two weeks on days 1, 4, 8, and 11 in a 21-day treatment cycle.
Croatian: VELCADE 1 mg prašak za otopinu za injekciju se primjenjuje putem intravenske injekcije pri preporučenoj dozi od 1,3 mg/m2 površine tijela, dva puta tjedno tijekom dva tjedna, 1., 4., 8. i 11. dana, u ciklusu liječenja od 21 dan.
English: There have been fatal cases of inadvertent intrathecal administration of VELCADE.
Croatian: Nenamjerna intratekalna primjena lijeka VELCADE dovela je do smrtnih slučajeva.
English: VELCADE 3.5 mg powder for solution for injection is administered via intravenous or subcutaneous injection at the recommended dose of 1.3 mg/m2 body surface area twice weekly for two weeks on days 1, 4, 8, and 11 in a 21 day treatment cycle.
Croatian: VELCADE 3,5 mg prašak za otopinu za injekciju se primjenjuje putem intravenske ili supkutane injekcije pri preporučenoj dozi od 1,3 mg/m2 površine tijela, dva puta tjedno tijekom dva tjedna, 1., 4., 8. i 11. dana, u ciklusu liječenja od 21 dan.
English: • Feeling dizzy
Croatian: • poremećaj dojki
English: [95% CI] Best response
Croatian: TTP, dani [95% CI] 1 godina preživljenja, % [95% CI] Najbolji odgovor
English: CR+nCR+ PR+MR Median duration Days (months) Time to response CR+PR (days)
Croatian: b 56 (18) CR+nCR+PR+MR 146 (46) 108 (35) Medijan trajanja dani (mjeseci) Vrijeme do odgovora CR+PR (dani)
English: Patients eligible for stem cell transplantation
Croatian: Prilagodbe doze za bolesnike za koje je prikladna transplantacija
English: ≥ 2 prior lines
Croatian: ≥ 1500 stanica/μL
English: Uncommon Infection*, Bacterial infections*, Viral infections*, Sepsis (inc septic shock)*, Bronchopneumonia, Herpes virus infection*, Meningoencephalitis herpetic
Croatian: Herpes zoster (uključujući diseminirani i oftalmički), pneumonija*, herpes simpleks*, gljivična infekcija* Manje često Infekcija*, bakterijske infekcije*, virusne infekcije *, sepsa (uključujući septički šok)*, bronhopneumonija, infekcija virusom herpesa*, herpetični meningoencefalitis
English: A 6-week period is considered a treatment cycle.
Croatian: To razdoblje od 3 tjedna smatra se jednim ciklusom liječenja.
English: METHOD OF ADMINISTRATION
Croatian: POSTUPAK PRAVILNOG ZBRINJAVANJA
English: • Cancer of the kidney
Croatian: • karcinom bubrega
English: If any discolouration or particulate matter is observed, the solution should be discarded.
Croatian: Ukoliko se uoči promjena boje ili prisutnost stranih čestica, otopinu je potrebno prikladno zbrinuti.
English: SGOT (AST) levels
Croatian: Razina bilirubina Razine SGOT (AST)
English: For single use only Do not give by other routes.
Croatian: Ne primjenjivati drugim putevima primjene.
English: Dehydration, Hypokalaemia*, Hyponatraemia*, Blood glucose abnormal*, Hypocalcaemia*, Enzyme abnormality*
Croatian: Hipokalijemija *, abnormalna vrijednost glukoze u krvi *, hiponatrijemija*, dijabetes melitus*, retencija tekućine Manje često Sindrom lize tumora
English: Very Common Thrombocytopenia*, Neutropenia*, Anaemia* Common
Croatian: *, neutropenija *, anemija* Često
English: Uncommon Cerebrovascular accident
Croatian: Klasifikacija organskih sustava Incidencija Nuspojava
English: Date of first authorisation: 2 December 2015
Croatian: Datum prvog odobrenja: 2 Prosinca 2015.
English: (listed in section 6).
Croatian: (naveden u dijelu 6).
English: This combination should be used with caution.
Croatian: Tu kombinaciju treba primjenjivati oprezno.
English: Read all of this leaflet carefully before you start receiving this medicine because it contains important information for you.
Croatian: Pažljivo pročitajte cijelu uputu prije nego što počnete uzimati ovaj lijek jer sadrži Vama važne podatke
English: Treatment may be delayed to allow sufficient time for recovery.
Croatian: Ciklus se može odgoditi kako bi se ostavilo dovoljno vremena za oporavak.
English: Infection (sepsis) may be severe and could lead to death.
Croatian: Infekcija (sepsa) može biti teška i može dovesti do smrti.
English: Be careful when driving a car or using machines.
Croatian: Budite oprezni kada upravljate vozilima ili rukujete strojevima.
English: 95 % CI for median HR
Croatian: 95% CI za medijan HR
English: Loss of appetite
Croatian: Gubitak apetita
English: The risk is increased in subjects who are already immunosuppressed by their underlying disease.
Croatian: Rizik je veći u osoba koje su već imunosuprimirane zbog podležeće bolesti.
English: Rarely, skin reactions may be severe and could lead to death.
Croatian: Kožne reakcije rijetko mogu biti teške i dovesti do smrti.
English: If you are pregnant, think you may be pregnant or are planning to have a baby,, tell your doctor.
Croatian: Ako ste trudni , mislite da biste mogli biti trudni ili planirate imati dijete, obavijestite o tome svog liječnika.
English: The results of these analyses of efficacy are summarised in the table below:
Croatian: Rezultati tih analiza djelotvornosti sažeto su prikazani u tablici koja slijedi:
English: Based on the planned date of your infusion of CIAMBRA and/or on the status of your kidney function, your doctor needs to advise you on which medicines you can take and when you can take them.
Croatian: Ovisno o planiranom datumu primjene infuzije lijeka CIAMBRA i/ili Vašoj bubrežnoj funkciji, liječnik Vas mora savjetovati o tome koje lijekove možete uzimati i kada ih možete uzimati.
English: Other medicines and CIAMBRA
Croatian: Drugi lijekovi i CIAMBRA
English: Talk to your doctor or pharmacist before receiving CIAMBRA.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primite lijek CIAMBRA.
English: What CIAMBRA is and what it is used for
Croatian: Što je CIAMBRA i za što se koristi
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: • Uoči svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama korist/rizik,odnosno kada je omjer korist/rizik rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili smanjenja rizika).
English: Your doctor will discuss with you the potential risk of taking CIAMBRA during pregnancy.
Croatian: Liječnik će s Vama razgovarati o mogućem riziku primjene lijeka CIAMBRA u trudnoći.
English: PFS data were partially confirmed by an independent review (400/1725 patients were randomly selected for review).
Croatian: Podaci za PFS djelomice su potvrđeni neovisnom procjenom (za pregled je nasumce odabrano 400/1725 bolesnika).
English: - if you are allergic (hypersensitive) to pemetrexed or any of the other ingredients of CIAMBRA
Croatian: - ako ste alergični (preosjetljivi) na pemetreksed ili neki drugi sastojak lijeka CIAMBRA
English: In vitro studies indicate that pemetrexed is approximately 81 % bound to plasma proteins.
Croatian: Ispitivanja in vitro pokazuju da se oko 81 % pemetrekseda veže za proteine plazme.
English: You must contact your doctor immediately if you notice any of the following: Fever or infection: if you have a temperature of 38ºC or greater, sweating or other signs of infection (since you might have less white blood cells than normal).
Croatian: Morate se odmah javiti svom liječniku ako primijetite bilo što od sljedećeg: vrućicu ili infekciju: ako imate tjelesnu temperaturu 38ºC ili višu, ako se znojite ili imate neke druge znakove infekcije (budući da možete imati manje bijelih krvnih stanica nego što je normalno).
English: Instructions for use, handling and disposal.
Croatian: Upute za uporabu, rukovanje i odlaganje
English: CIAMBRA is a medicine used in the treatment of cancer.
Croatian: CIAMBRA je lijek koji se koristi za liječenje raka.
English: Cisplatin is also given by infusion into one of your veins, and is given approximately 30 minutes after the infusion of CIAMBRA has finished.
Croatian: Cisplatin se također primjenjuje infuzijom u jednu od vena i daje se otprilike 30 minuta nakon završetka infuzije lijeka CIAMBRA.
English: You must take at least 5 doses during the seven days before the first dose of CIAMBRA.
Croatian: Morate uzeti barem 5 doza tijekom 7 dana prije prve doze lijeka CIAMBRA.
English: Survival time (months) Median (m)
Croatian: Vrijeme preživljenja (mjeseci) Medijan (m)
English: Excluding neurotoxicity
Croatian: Osim neurotoksičnosti
English: Statistically significant for noninferiority, with the entire confidence interval for HR well below the 1.17645 noninferiority margin (p <0.001).
Croatian: a Statistički značajno za neinferiornost, cijeli interval pouzdanosti za HR znatno ispod granice neinferiornosti od 1,17645 (p <0,001).
English: Caution should be made when these drugs are combined with pemetrexed.
Croatian: Nužan je oprez kada se ti lijekovi kombiniraju s pemetreksedom.
English: What CIAMBRA contains
Croatian: Što CIAMBRA sadrži
English: To reduce the incidence and severity of skin reactions, a corticosteroid should be given the day prior to, on the day of, and the day after pemetrexed administration.
Croatian: Kako bi se smanjila incidencija i težina kožnih reakcija, treba dati kortikosteroid dan prije, na sam dan i dan nakon primjene pemetrekseda.
English: If a pemetrexed solution contacts the skin, wash the skin immediately and thoroughly with soap and water.
Croatian: Ako otopina pemetrekseda dođe u dodir s kožom, odmah temeljito operite kožu sapunom i vodom.
English: From a microbiological point of view, the infusion solution should be used immediately.
Croatian: S mikrobiološkog stajališta otopina za infuziju se mora odmah primijeniti.
English: Female fertility was not investigated.
Croatian: Utjecaj na plodnost ženki nije ispitana.
English: The efficacy analyses using PQ population are consistent with the analyses for the ITT population and support the non-inferiority of AC versus GC.
Croatian: Analize djelotvornosti u PQ populaciji konzistentne su analizom ITT populacije i podupiru neinferiornost AC u odnosu na GC.
English: See section 4.
Croatian: Prilog IV.
English: White to almost white lyophilised powder.
Croatian: Bijeli do gotovo bijeli liofilizirani prašak.
English: If necessary, creatinine clearance should be closely monitored.
Croatian: Bude li potrebno, treba pažljivo nadzirati klirens kreatinina.
English: Concomitant use contraindicated: Yellow fever vaccine: risk of fatal generalised vaccinale disease (see section 4.3).
Croatian: Istodobna primjena kontraindicirana: cjepivo protiv žute groznice: rizik od smrtonosne generalizirane vakcinalne bolesti (vidjeti dio 4.3).
English: The reconstituted solution should be used immediately to prepare the infusion solution.
Croatian: Rekonstituirana otopina se mora odmah koristiti za pripremu otopine za infuziju.
English: Pemetrexed should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus (see section 4.4).
Croatian: Pemetreksed se ne smije primjenjivati tijekom trudnoće, osim ako je to doista nužno i nakon pažljive procjene potreba majke i rizika za plod (vidjeti dio 4.4).
English: Pemetrexed is primarily eliminated in the urine, with 70 % to 90 % of the administered dose being recovered unchanged in urine within the first 24 hours following administration.
Croatian: Eliminira se prvenstveno urinom, pri čemu se 70 % do 90 % primijenjene doze nađe u urinu u nepromijenjenu obliku tijekom prva 24 sata nakon primjene.
English: What you need to know before you use CIAMBRA
Croatian: Što morate znati prije nego što počnete primati lijek CIAMBRA
English: Please tell your doctor if you are taking any medicine for pain or inflammation (swelling), such as medicines called “nonsteroidal anti-inflammatory drugs” (NSAIDs), including medicines purchased without a doctor's prescription (such as ibuprofen).
Croatian: Obavijestite svog liječnika ako uzimate bilo koji lijek protiv bolova ili upale (otekline), poput lijekova iz skupine takozvanih “nesteroidnih protuupalnih lijekova” (NSAIL), uključujući lijekove koje ste nabavili bez liječničkog recepta (poput ibuprofena).
English: This medicine is given to you to reduce the frequency and severity of skin reactions that you may experience during your anticancer treatment.
Croatian: Taj Vam se lijek daje kako bi se smanjile učestalost i težina kožnih reakcija koje se mogu pojaviti tijekom liječenja raka.
English: However, it has been reported that pemetrexed may cause fatigue.
Croatian: Ipak, prijavljeno je da pemetreksed može izazvati umor.
English: The use of CIAMBRA should be avoided during pregnancy.
Croatian: Primjena lijeka CIAMBRA mora se izbjegavati tijekom trudnoće.
English: ITT population and histology subgroups
Croatian: ITT populacija i podskupine prema histološkom tipu tumora
English: Hair loss
Croatian: Ispadanje kose
English: This medicine is for single use only; any unused solution must be disposed of in accordance with local requirement.
Croatian: Ovaj lijek je samo za jednokratnu primjenu; neiskorištena otopina mora se zbrinuti sukladno lokalnim propisima.
English: You must continue taking the folic acid for 21 days after the last dose of CIAMBRA.
Croatian: Morate nastaviti uzimati folatnu kiselinu uzimati 21 dan nakon posljednje doze lijeka CIAMBRA.
English: You will always receive CIAMBRA by infusion into one of your veins.
Croatian: Lijek CIAMBRA ćete uvijek primati infuzijom u jednu od vena.
English: Therefore, all patients treated with pemetrexed must be instructed to take folic acid and vitamin B12 as a prophylactic measure to reduce treatment-related toxicity (see section 4.2).
Croatian: Stoga se sve bolesnike koji primaju pemetreksed mora uputiti da uzimaju folatnu kiselinu i vitamin B12 kao profilaktičku mjeru za smanjenje toksičnosti povezane s liječenjem (vidjeti dio 4.2).
English: Like all medicines, this medicine can cause side effects, although not everybody gets them.
Croatian: Moguće nuspojave Kao i svi ljekovi, ovaj lijek može uzrokovati nuspojave iako se one neće javiti kod svakoga.
English: It is a white to almost white lyophilised powder.
Croatian: To je bijeli do gotovo bijeli liofilizirani prašak.
English: At least five doses of folic acid must be taken during the seven days preceding the first dose of pemetrexed, and dosing must continue during the full course of therapy and for 21 days after the last dose of pemetrexed.
Croatian: Najmanje pet doza folatne kiseline treba uzeti tijekom sedam dana koji prethode prvoj dozi pemetrekseda, i doziranje se mora nastaviti tijekom cijelog trajanja liječenja i još 21 dan nakon posljednje doze pemetrekseda.
English: Owing to the possibility of pemetrexed treatment causing irreversible infertility, men are advised to seek counselling on sperm storage before starting treatment.
Croatian: Zbog mogućnosti da liječenje pemetreksedom prouzroči ireverzibilnu neplodnost, muškarcima se savjetuje da se prije početka liječenja posavjetuju o pohrani sperme.
English: If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive CIAMBRA.
Croatian: Ako trenutno imate ili ste prethodno imali problema s bubrezima, obratite se svom liječniku ili bolničkom ljekarniku, jer možda nećete smjeti primati lijek CIAMBRA.
English: Concomitant use not recommended: Live attenuated vaccines (except yellow fever, for which concomitant use is contraindicated): risk of systemic, possibly fatal, disease.
Croatian: Istodobna primjena se ne preporučuje: živa atenuirana cjepiva (osim cjepiva protiv žute groznice, čija je istodobna primjena kontraindicirana): rizik od sustavne bolesti koja može biti smrtonosna.
English: This is equivalent to 2,7% of the recommended maximum daily dietary intake of sodium for an adult.
Croatian: 2,7% preporučenog maksimalnog dnevnog unosa soli za odraslu osobu.
English: What CIAMBRA looks like and contents of the pack
Croatian: Kako CIAMBRA izgleda i sadržaj pakiranja
English: Due to the gastrointestinal toxicity of pemetrexed given in combination with cisplatin, severe dehydration has been observed.
Croatian: Zbog gastrointestinalne toksičnosti pemetrekseda primijenjenog u kombinaciji s cisplatinom uočena je teška dehidracija.
English: You will also receive an injection of vitamin B12 (1000 micrograms) in the week before administration of CIAMBRA and then approximately every 9 weeks (corresponding to 3 courses of CIAMBRA treatment).
Croatian: Također ćete dobiti injekciju vitamina B12 (1000 mikrograma) u tjednu prije primjene lijeka CIAMBRA i zatim otprilike svakih 9 tjedana (što odgovara 3 ciklusa liječenja lijekom
English: Therefore, patients should receive adequate antiemetic treatment and appropriate hydration prior to and/or after receiving treatment.
Croatian: Stoga bolesnici moraju primiti odgovarajući antiemetik i prikladnu hidrataciju prije i/ili nakon primjene terapije.
English: Particular attention should be paid to these patients and caution exercised with use of other radiosensitising agents.
Croatian: Potrebno je obratiti posebnu pozornost na te bolesnike i uz oprez primjenjivati druge lijekove koji povećavaju osjetljivost na zračenje.
English: Response (n: qualified for response) Response rate (%) (95 % CI) Stable disease (%)
Croatian: Odgovor (N: broj bolesnika u kojih se mogao ocijeniti odgovor) Stopa odgovora (%) (95% CI) Stabilna bolest (%)
English: The 1 year and 2 year survival rates for patients on pemetrexed were 58% and 32% respectively, compared to 45% and 21% for patients on placebo.
Croatian: Stope jednogodišnjeg i dvogodišnjeg preživljenja bolesnika liječenih pemetreksedom iznosile su 58% odnosno 32%, u usporedbi s 45% odnosno 21% za bolesnike koji su primali placebo.
English: Men are advised not to father a child during and up to 6 months following treatment with CIAMBRA and should therefore use effective contraception during treatment with CIAMBRA and for up to 6 months afterwards.
Croatian: Muškarcima se savjetuje da ne začinju djecu tijekom liječenja i do 6 mjeseci nakon završetka liječenja lijekom CIAMBRA te stoga moraju primjenjivati djelotvornu kontracepciju tijekom liječenja lijekom CIAMBRA i do 6 mjeseci nakon njegova završetka.
English: Before each infusion you will have samples of your blood taken to evaluate if you have sufficient kidney and liver function and to check that you have enough blood cells to receive CIAMBRA.
Croatian: Prije svake infuzije uzet će Vam se uzorak krvi kako bi se provjerilo jesu li Vam bubrežna i jetrena funkcija dovoljno dobre i imate li dovoljno krvnih stanica da biste primili lijek CIAMBRA.
English: When using CIAMBRA in combination with cisplatin:
Croatian: Kada se CIAMBRA primjenjuje u kombinaciji sa cisplatinom:
English: At the time of this final survival analysis, 28.7% of patients were alive or lost to follow up on the pemetrexed arm versus 21.7% on the placebo arm.
Croatian: U vrijeme ove konačne analize preživljenja 28,7% bolesnika u skupini liječenoj pemetreksedom bilo je živo ili izgubljeno za praćenje, u odnosu na 21,7% bolesnika u skupini koja je primala placebo.
English: CIAMBRA can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Croatian: CIAMBRA Vam može biti propisana ako imate rak pluća u uznapredovaloj fazi i ako je Vaša bolest reagirala na liječenje ili ostala uglavnom nepromijenjena nakon početne kemoterapije.
English: This dose may be adjusted, or treatment may be delayed depending on your blood cell counts and on your general condition.
Croatian: Doza se može prilagoditi ili se liječenje može odgoditi, ovisno o broju krvnih stanica i Vašem općem stanju.
English: Allergic reaction: if you develop skin rash / burning or prickling sensation, or fever.
Croatian: alergijska reakcija: ako se razvije kožni osip / osjećaj pečenja ili bockanja ili vrućica.
English: Safety was assessed for patients who were randomised to receive pemetrexed (N=800).
Croatian: Sigurnost primjene procijenjena je u bolesnika randomiziranih da primaju pemetreksed (N=800).
English: Most of the patients in whom these events have been observed had preexisting cardiovascular risk factors (see section 4.8).
Croatian: U većine bolesnika u kojih su opaženi takvi događaji, od ranije su postojali kardiovaskularni čimbenici rizika (vidjeti dio 4.8).
English: A total of 169 patients (47.1%) completed ≥ 6 cycles maintenance treatment with pemetrexed, representing at least 10 total cycles of pemetrexed.
Croatian: Ukupno 169 bolesnika (47,1%) završilo je ≥ 6 ciklusa terapije održavanja pemetreksedom, što predstavlja najmanje 10 ciklusa pemetrekseda.
English: To reduce toxicity, patients treated with pemetrexed must also receive vitamin supplementation (see section 4.4).
Croatian: Kako bi se smanjila toksičnost, bolesnici liječeni pemetreksedom moraju primati i vitaminsku nadoknadu (vidjeti dio 4.4).
English: If you are also receiving cisplatin, your doctor will make sure that you are properly hydrated and receive appropriate treatment before and after receiving cisplatin to prevent vomiting.
Croatian: Ako primate i cisplatin, liječnik će se pobrinuti da budete primjereno hidrirani i da prije i nakon primanja cisplatina dobijete odgovarajuće lijekove za sprječavanje povraćanja.
English: The European Medicines Agency has waived the obligation to submit the results of studies with pemetrexed in all subsets of the paediatric population in the granted indications (see section 4.2).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja pemetrekseda u svim podskupinama pedijatrijske populacije za odobrene indikacije (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: Calculate the dose and the number of CIAMBRA vials needed.
Croatian: Izračunajte dozu i potreban broj bočica lijeka CIAMBRA.
English: Pemetrexed total systemic clearance is 91.8 ml/min and the elimination half-life from plasma is 3.5 hours in patients with normal renal function (creatinine clearance of 90 ml/min).
Croatian: Ukupni sistemski klirens pemetrekseda je 91,8 ml/min, a poluvrijeme eliminacije iz plazme iznosi 3,5 sata u bolesnika s normalnom bubrežnom funkcijom (klirens kreatinina 90 ml/min).