FrancophonIA/ELRC3.0 huggingface dataset:
English: This results in even felodipine plasma concentrations within the therapeutic range for 24 hours.
Slovenian: Posledica je enakomerna koncentracija felodipina v plazmi, ki je znotraj terapevtskega razpona 24 ur.
English: INFORMATION IN BRAILLE <Justification for not including Braille accepted> [To be completed nationally]
Slovenian: PODATKI V BRAILLOVI PISAVI <Sprejeta je utemeljitev, da Braillova pisava ni potrebna.>
English: Tacrolimus: Felodipine may increase the concentration of tacrolimus.
Slovenian: Takrolimus: Felodipin lahko poveča koncentracijo takrolimusa.
English: Do not drink grapefruit juice if you are treated with Plendil, as this may increase the effect of Plendil and the risk of side effects.
Slovenian: Če jemljete zdravilo Plendil, ne smete uživati grenivkinega soka, ker to lahko poveča učinek zdravila Plendil in tveganje za neželene učinke.
English: Felodipine reduces both systolic and diastolic blood pressure and can be used in isolated systolic hypertension.
Slovenian: Felodipin zniža sistolični in diastolični krvni tlak in ga je mogoče uporabiti pri izolirani sistolični hipertenziji.
English: Symptoms of excessive low blood pressure and inadequate blood supply to the heart itself, frequently include dizziness and chest pain.
Slovenian: Med simptomi prevelikega znižanja krvnega tlaka in nezadostne prekrvitve samega srca sta pogosto omotica in bolečine za prsnico.
English: According to the STOP-2 (Swedish Trial in Old Patients with Hypertension-2 study), performed in 6614 patients, aged 70-84 years, dihydropyridine calcium antagonists (felodipine and isradipine) have shown the same preventive effect on cardiovascular mortality and morbidity as other commonly used classes of antihypertensive medicinal products - ACE inhibitors, beta-blockers and diuretics.
Slovenian: Glede na izsledke študije STOP-2 (Swedish Trial in Old Patients with Hypertension-2), ki je zajela 6614 bolnikov, starih od 70 do 84 let, sta imela dihidropiridinska kalcijeva antagonista (felodipin in isradipin) na kardiovaskularno umrljivost in obolevnost enak preventivni učinek kot druge pogosto uporabljane skupine antihipertenzivnih zdravil - zaviralci ACE, blokatorji beta in diuretiki.
English: There are no data on the effects of felodipine on patient fertility.
Slovenian: Podatkov o vplivih felodipina na plodnost bolnikov ni.
English: • medicines to treat HIV infection (such as efavirenz, nevirapine)
Slovenian: • zdravila za zdravljenje okužbe s HIV (npr. efavirenz, nevirapin)
English: Some medicines/herbal remedies can affect treatment with Plendil.
Slovenian: Nekatera zdravila in nekateri pripravki rastlinskega izvora lahko vplivajo na zdravljenje z zdravilom Plendil.
English: Elderly people Your doctor may initiate treatment with the lowest available dose.
Slovenian: Zdravnik lahko vaše zdravljenje začne z najmanjšim odmerkom, ki je na voljo.
English: Felodipine is effective in all grades of hypertension.
Slovenian: Felodipin je učinkovit pri hipertenziji vseh stopenj.
English: Felodipine can cause flushing, headache, palpitations, dizziness and fatigue.
Slovenian: Felodipin lahko povzroči vročinske oblive, glavobol, palpitacije, omotico in utrujenost.
English: It is bound pre-dominantly to the albumin fraction.
Slovenian: Vezan je pretežno na albuminsko frakcijo.
English: Plasma concentrations are directly proportional to dose within the therapeutic dose range 2.5 - 10 mg.
Slovenian: Koncentracija v plazmi je v razponu terapevtskih odmerkov od 2,5 do 10 mg neposredno sorazmerna odmerku.
English: In order to keep the prolongedrelease properties, the tablets must not be divided, crushed or chewed.
Slovenian: Za ohranitev delovanja s podaljšanim sproščanjem se tablet ne sme lomiti, zdrobiti ali zgristi.
English: Depending on the patient's response, the dosage can, where applicable, be decreased to 2.5 mg or increased to 10 mg daily.
Slovenian: Odvisno od bolnikovega odziva je mogoče odmerek (če to pride v poštev) zmanjšati na 2,5 mg ali povečati na 10 mg na dan.
English: Cyclosporin: Felodipine does not affect plasma concentrations of cyclosporin.
Slovenian: Ciklosporin: Felodipin ne vpliva na koncentracijo ciklosporina v plazmi.
English: Felodipine does not influence urinary albumin excretion.
Slovenian: Felodipin ne vpliva na izločanje albumina v urinu.
English: Patients with rare hereditary problems of galactose intolerance or glucosegalactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: It can be used as monotherapy or in combination with other antihypertensive medicinal products, eg, ß-adrenoceptor blockers, diuretics or ACE-inhibitors, in order to achieve an increased antihypertensive effect.
Slovenian: Uporabiti ga je mogoče kot samostojno zdravljenje (monoterapijo) ali v kombinaciji z drugimi antihipertenzivi, npr. blokatorji adrenergičnih receptorjev ß, diuretiki ali zaviralci ACE, da bi dosegli večji antihipertenzivni učinek.
English: In the HOT (Hypertension Optimal Treatment) study, the effect on major cardiovascular events (ie, acute myocardial infarction, stroke and cardiovascular death) was studied in relation to diastolic blood pressure targets < 90 mmHg, < 85 mmHg and < 80 mmHg and achieved blood pressure, with felodipine as baseline therapy.
Slovenian: V študiji HOT (Hypertension Optimal Treatment) so raziskali pojavljanje pomembnih kardiovaskularnih dogodkov (tj. akutnega miokardnega infarkta, možganske kapi in kardiovaskularne smrti) glede na ciljne vrednosti diastoličnega krvnega tlaka ≤ 90 mmHg, ≤ 85 mmHg in ≤ 80 mmHg ter doseženi krvni tlak; izhodiščno zdravilo je bil felodipin.
English: Talk to your doctor before taking Plendil, especially if you have problems with your liver.
Slovenian: Preden začnete jemati zdravilo Plendil, se posvetujte z zdravnikom, še posebej če imate težave z jetri.
English: Plendil, like other blood-pressure lowering medicinal products, may in rare cases lead to pronounced low blood pressure which in some patients may result in an inadequate supply of blood to the heart.
Slovenian: Tako kot druga zdravila za znižanje krvnega tlaka lahko tudi zdravilo Plendil v redkih primerih povzroči hud padec krvnega tlaka; to lahko pri nekaterih bolnikih povzroči nezadostno prekrvitev srca.
English: • Decompensated heart failure
Slovenian: • dekompenzirano srčno popuščanje
English: When felodipine was coadministered with carbamazepine, phenytoin or phenobarbital, the Cmax and AUC of felodipine were decreased by 82% and 96% respectively.
Slovenian: Če je bil felodipin uporabljen sočasno s karbamazepinom, fenitoinom ali fenobarbitalom, se je Cmax felodipina zmanjšala za 82 % in njegova AUC za 96 %.
English: Patients with impaired hepatic function may have elevated plasma concentrations of felodipine and may respond to lower doses (see section 4.4).
Slovenian: Bolniki z okvarjenim delovanjem jeter imajo lahko višjo koncentracijo felodipina v plazmi in se lahko odzovejo na manjše odmerke (glejte poglavje 4.4).
English: There is no risk of accumulation during long-term treatment.
Slovenian: Med dolgotrajnim zdravljenjem ni tveganja za kopičenje.
English: The usual dose when treating this disease for a long time is 5-10 mg once a day.
Slovenian: Običajen odmerek za dolgotrajno zdravljenje te bolezni je od 5 do 10 mg enkrat na dan.
English: Plendil extended release tablets should be taken in the morning and be swallowed with water.
Slovenian: Zdravilo Plendil tablete s podaljšanim sproščanjem je treba vzeti zjutraj in ga zaužiti z vodo.
English: Annex III Summary of product characteristics, labelling and package leaflet
Slovenian: POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJE IN NAVODILO ZA UPORABO
English: if you have disease of a heart valve or heart muscle, until you have talked to your doctor.
Slovenian: - če imate bolezen kakšne srčne zaklopke ali bolezen srčne mišice, se morate prej posvetovati z zdravnikom.
English: It lowers blood pressure by dilating small blood vessels.
Slovenian: Zniža krvni tlak, in sicer tako, da razširi male žile.
English: if you have chest pain of recent onset, or angina pectoris that is lasting for more than 15 minutes or longer or is more severe than usual.
Slovenian: - če imate bolečino za prsnico, ki se je začela pred kratkim, ali angino pektoris, ki traja več kot
English: If you experience symptoms such as feeling faint, light-headedness or dizziness, contact your doctor immediately.
Slovenian: Če se vam pojavijo simptomi, kot so občutek omedlevice, vrtoglavica ali omotica, se takoj se posvetujte z zdravnikom.
English: Stable angina pectoris
Slovenian: Stabilna angina pektoris
English: • Gingivitis (swollen gums)
Slovenian: • gingivitis (oteklina dlesni)
English: if you suffer from uncompensated heart failure.
Slovenian: - če imate dekompenzirano srčno popuščanje.
English: Elderly population Initial treatment with lowest available dose should be considered.
Slovenian: Starejša populacija V poštev pride uvedba zdravljenja z najmanjšim odmerkom, ki je na voljo.
English: In elderly patients, a starting dose of 2.5 mg daily may be considered.
Slovenian: Pri starejših bolnikih pride v poštev začetni odmerek 2,5 mg na dan.
English: Due to the high degree of selectivity for smooth muscle in the arterioles, felodipine in therapeutic doses has no direct effect on cardiac contractility or conduction.
Slovenian: Zaradi velike selektivnosti za gladke mišice arteriol felodipin v terapevtskih odmerkih nima neposrednega vpliva na krčljivost srca ali na prevajanje v srcu.
English: • Certain flavonoids present in grapefruit juice
Slovenian: • določeni flavonoidi, ki jih vsebuje grenivkin sok
English: Plendil and associated names (see Annex I) 2.5 mg prolonged-release tablets Plendil and associated names (see Annex I) 5 mg prolonged-release tablets Plendil and associated names (see Annex I) 10 mg prolonged-release tablets
Slovenian: Plendil in povezana imena (glejte Prilogo I) 2,5 mg tablete s podaljšanim sproščanjem Plendil in povezana imena (glejte Prilogo I) 5 mg tablete s podaljšanim sproščanjem Plendil in povezana imena (glejte Prilogo I) 10 mg tablete s podaljšanim sproščanjem
English: The following undesirable effects have been identified.
Slovenian: Ugotovljeni so bili spodaj navedeni neželeni učinki.
English: Detailed information on this medicine is available on the website of {MS/Agency}
Slovenian: [Izpolni država članica] Podrobne informacije o zdravilu so objavljene na spletni strani {ime DČ/agencije}
English: The tablet must not be divided, crushed or chewed.
Slovenian: Tablet ne smete lomiti, drobiti ali zgristi.
English: In a study on fertility and general reproductive performance in rats treated with felodipine, a prolongation of parturition resulting in difficult labour/increased foetal deaths and early postnatal deaths was observed in the medium and high dose groups.
Slovenian: Vpliv na sposobnost razmnoževanja V študiji plodnosti in splošne sposobnosti razmnoževanja na podganah, ki so dobivale felodipin, so v skupinah, ki sta prejemali srednji in visoki odmerek, ugotovili podaljšanje porajanja s posledično težjim skotenjem/povečano smrtnostjo plodov in pogostnostjo smrti zgodaj po skotitvi.
English: The extended-release tablets produce a prolonged absorption phase of felodipine.
Slovenian: Tablete s podaljšanim sproščanjem podaljšajo fazo absorpcije felodipina.
English: The adverse reactions listed below have been identified from clinical trials and from post marketing surveillance.
Slovenian: Seznam neželenih učinkov v preglednici Spodaj navedeni neželeni učinki so bili ugotovljeni v kliničnih preskušanjih in med spremljanjem v obdobju trženja.
English: Felodipine is administered as extended-release tablets, from which it is completely absorbed in the gastrointestinal tract.
Slovenian: Felodipin se uporablja v tabletah s podaljšanim sproščanjem, iz katerih se popolnoma absorbira v prebavilih.
English: When felodipine and erythromycin were coadministered, the Cmax and AUC of felodipine were increased by about 2.5-fold.
Slovenian: Če je bil felodipin uporabljan sočasno z eritromicinom, sta se Cmax in AUC felodipina povečali za približno 2,5-krat.
English: Should such reactions occur, they are usually brief and diminish in intensity with time.
Slovenian: Če se pojavijo, so po navadi kratkotrajni in se sčasoma ublažijo.
English: If you forget to take Plendil
Slovenian: Če ste pozabili vzeti zdravilo Plendil
English: • Too low blood pressure (hypotension)
Slovenian: • prenizek krvni tlak (hipotenzija) • navzea (siljenje na bruhanje)
English: • Abnormally rapid heart rate
Slovenian: • nenormalno hitro bitje srca
English: • Hypersensitivity and allergic reactions: The signs may include raised lumps on your skin (weals) or swelling of your face, lips, mouth, tongue or throat.
Slovenian: Med znaki so lahko dvignjene bule na koži (koprivnica) ali oteklost obraza, ustnic, ust, jezika ali žrela.
English: The standard maintenance dose is 5 mg once daily.
Slovenian: Običajni vzdrževalni odmerek je 5 mg enkrat na dan.
English: If you stop taking Plendil
Slovenian: Če ste prenehali jemati zdravilo Plendil
English: 5 mg tablet
Slovenian: 5-mg tableta
English: Treatment should be started with 5 mg once a day and if needed, your doctor may increase the dose to 10 mg once a day.
Slovenian: Zdravljenje je treba začeti z odmerkom 5 mg enkrat na dan; če je treba, vam zdravnik odmerek lahko poveča na 10 mg enkrat na dan.
English: If you take more Plendil than you should
Slovenian: Če ste vzeli večji odmerek zdravila Plendil, kot bi smeli
English: Plendil can have minor or moderate influence on your ability to drive and use machines.
Slovenian: Zdravilo Plendil ima lahko blag ali zmeren vpliv na sposobnost upravljanja vozil in strojev.
English: Felodipine is a vascular selective calcium antagonist, which lowers arterial blood pressure by decreasing systemic vascular resistance.
Slovenian: Felodipin je žilno selektiven kalcijev antagonist, ki zniža krvni tlak z zmanjšanjem sistemskega žilnega upora.
English: Pharmacotherapeutic group: calcium channel blockers, dihydropyridine derivatives; ATC code: C08CA02
Slovenian: 5.1 Farmakodinamične lastnosti Farmakoterapevtska skupina: zaviralci kalcijevih kanalčkov, derivati dihidropiridina; oznaka ATC:
English: Felodipine may also improve early renal graft function.
Slovenian: Izboljša lahko tudi zgodnje delovanje presajene ledvice.
English: • tacrolimus (medicine used in organ transplantations)
Slovenian: • takrolimus (zdravilo, ki se uporablja po presaditvi organa)
English: Hydroxypropylcellulose Hypromellose 50 mPa·s Hypromellose 10000 mPa·s Lactose anhydrous Microcrystalline cellulose Polyoxyl 40 hydrogenated castor oil Propyl gallate
Slovenian: Jedro tablete hidroksipropilceluloza hipromeloza 50 mPa·s hipromeloza 10000 mPa·s laktoza, brezvodna mikrokristalna celuloza makrogolglicerol hidroksistearat 40 propilgalat natrijev aluminijev silikat natrijev stearilfumarat
English: • Acute myocardial infarction
Slovenian: • akutni miokardni infarkt
English: • Hypericum perforatum (Saint John's wort)
Slovenian: • Hypericum perforatum (šentjanževka)
English: What Plendil contains
Slovenian: Kaj vsebuje navodilo
English: This belongs to a group of medicinces called calcium antagonists.
Slovenian: imenovanih kalcijevi antagonisti.
English: In a randomised, double-blind, 3-week, parallel group study in children aged 6-16 years with primary hypertension, the antihypertensive effects of once daily felodipine 2.5 mg (n=33), 5 mg (n=33) and 10 mg (n=31) were compared with placebo (n=35).
Slovenian: V randomizirani, dvojno slepi 3-tedenski študiji vzporednih skupin pri otrocih s primarno hipertenzijo, starih od 6 do 16 let, so antihipertenzivne učinke 2,5 mg felodipina (n = 33), 5 mg
English: Felodipine improves exercise tolerance and reduces anginal attacks in patients with stable effort-induced angina pectoris.
Slovenian: Felodipin izboljša toleranco za telesno obremenitev in bolnikom s stabilno angino pektoris, ki jo izzove napor, zmanjša napade angine pektoris.
English: Felodipine possesses a mild natriuretic/diuretic effect and fluid retention does not occur.
Slovenian: Felodipin ima blag natriuretičen/diuretičen učinek in ne povzroča zastajanja tekočine.
English: Felodipine is metabolised in the liver by cytochrome P450 3A4 (CYP3A4).
Slovenian: Felodipin se presnavlja v jetrih s citokromom P450 3A4 (CYP3A4).
English: There is no significant accumulation during long-term treatment.
Slovenian: Med dolgotrajnim zdravljenjem se ne kopiči v pomembni meri.
English: Felodipine does not affect daily potassium excretion.
Slovenian: Felodipin ne vpliva na dnevno izločanje kalija.
English: If you experience any of the following symptoms and they persist, please tell your doctor.
Slovenian: Če se vam kateri od teh simptomov pojavi in traja, vas prosimo, da to poveste zdravniku.
English: The combination with strong CYP3A4 inducers should be avoided.
Slovenian: Kombinacijam z močnimi induktorji CYP3A4 se je treba izogibati.
English: If patients taking felodipine suffer from headache, nausea, dizziness or fatigue and ability to react may be impaired.
Slovenian: Če se bolniku, ki jemlje felodipin, pojavi glavobol, navzea, omotica ali utrujenost, se mu reakcijska sposobnost lahko poslabša.
English: Plendil contains lactose.
Slovenian: Zdravilo Plendil vsebuje laktozo.
English: • Erythromycin
Slovenian: • eritromicin
English: Plendil contains castor oil, which may cause stomach upset and diarrhoea.
Slovenian: Zdravilo Plendil vsebuje ricinusovo olje, ki lahko povzroči težave z želodcem in drisko.
English: • Ketoconazole
Slovenian: • ketokonazol
English: • medicines to treat HIV protease inhibitors (such as ritonavir)
Slovenian: • zdravila za zdravljenje HIV, ki jih imenujemo zaviralci proteaz (npr. ritonavir)
English: How to store Plendil Contents of the pack and other information
Slovenian: Shranjevanje zdravila Plendil Vsebina pakiranja in dodatne informacije
English: There is limited clinical trial experience of the use of felodipine in hypertensive paediatric patients.
Slovenian: Pediatrična populacija Izkušenj iz kliničnih preskušanj z uporabo felodipina pri hipertenzivnih pediatričnih bolnikih je malo.
English: 10 mg tablet
Slovenian: 10-mg tableta
English: What Plendil looks like and contents of the pack
Slovenian: Izgled zdravila Plendil in vsebina pakiranja
English: Plasma concentrations of felodipine are positively correlated to the decrease in total peripheral resistance and blood pressure.
Slovenian: Koncentracija felodipina v plazmi pozitivno korelira z zmanjšanjem celotnega perifernega upora in znižanjem krvnega tlaka.
English: Consequently higher therapeutic concentrations and response can be expected in patients with clearly reduced liver function (see section 4.2).
Slovenian: Zato je mogoče pri bolnikih z izrazito zmanjšanim delovanjem jeter pričakovati večje terapevtske koncentracije in večji odziv (glejte poglavje 4.2).
English: • Nevirapine
Slovenian: • nevirapin
English: The primary haemodynamic effect of felodipine is a reduction of total peripheral vascular resistance, which leads to a decrease in blood pressure.
Slovenian: Primarni hemodinamski učinek felodipina je znižanje celotnega perifernega žilnega upora, s čimer zniža krvni tlak.
English: If you take more than the recommended number of doses of Plendil, you may suffer from very low blood pressure and sometimes palpitations, high or, rarely, slow heart rate.
Slovenian: Če ste vzeli večji odmerek zdravila Plendil, kot bi smeli, se vam lahko krvni tlak zelo zniža, v nekaterih primerih lahko pride do palpitacij (občutka razbijanja srca) ali pa se vam srčni utrip pospeši ali redkeje upočasni.
English: In a single dose (felodipine prolonged-release 5 mg) pharmacokinetic study with a limited number of children aged between 6 and 16 years (n=12) there was no apparent relationship between the age and AUC, Cmax or half-life of felodipine.
Slovenian: Pediatrična populacija V farmakokinetični študiji enkratnega odmerka (felodipin s podaljšanim sproščanjem 5 mg) pri majhnem številu otrok, starih od 6 do 16 let (n = 12) ni bilo opazne povezanosti med starostjo in
English: If you experience headache, nausea, dizziness or fatigue your ability to react may be impaired.
Slovenian: Če se vam pojavijo glavobol, siljenje na bruhanje, omotica ali utrujenost, to lahko poslabša vašo sposobnost za reagiranje.
English: The reduction in systemic blood pressure caused by felodipine leads to decreased left ventricular afterload and myocardial oxygen demand.
Slovenian: Znižanje sistemskega krvnega tlaka, ki ga povzroči felodipin, zmanjša sistolično breme ("afterload") levega prekata in potrebo miokarda po kisiku.
English: • Unstable angina pectoris
Slovenian: • nestabilna angina pektoris
English: Do not use this medicine after the expiry date which is stated on the carton, blister and bottle after ‘EXP'.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli,
English: Plendil contains lactose and castor oil
Slovenian: Zdravilo Plendil vsebuje laktozo in ricinusovo olje
English: Felodipine was given as monotherapy or in combination with a betablocker, and/or an ACE-inhibitor and/or a diuretic.
Slovenian: Felodipin je bil uporabljen kot monoterapija ali v kombinaciji z blokatorjem adrenergičnih receptorjev beta in/ali zaviralcem ACE in/ali diuretikom.
English: In a reproduction study in monkeys, an abnormal position of the distal phalange(s) was noticed.
Slovenian: V študiji sposobnosti razmnoževanja pri opicah so ugotovili nenormalen položaj distalne falange/distalnih falang.
English: Felodipine in therapeutic doses has no effect on cardiac contractility or atrioventricular conduction or refractoriness.
Slovenian: Učinki na srce Felodipin v terapevtskih odmerkih ne vpliva na krčljivost srca, atrioventrikularno prevajanje ali refraktarnost.
English: What you need to know before you take Plendil
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Plendil Ne jemljite zdravila Plendil
English: Plendil and associated names (see Annex I) 2.5 mg [5 mg or, 10 mg] prolonged-release tablets [See Annex I - To be completed nationally] felodipine
Slovenian: Navodilo za uporabo Plendil in povezana imena (glejte Prilogo I) 2,5 mg [5 mg ali 10 mg] tablete s podaljšanim sproščanjem [Glejte Prilogo I - Izpolni država članica]
English: Reproduction studies in rabbits have shown a dose-related reversible enlargement of the mammary glands of the parent animals and dose-related digital anomalies in the foetuse.
Slovenian: Študije vpliva na sposobnost razmnoževanja na kuncih so pokazale z odmerkom povezano reverzibilno povečanje mlečnih žlez pri živalih-starših in z odmerkom povezane nepravilnosti prstov pri plodovih.
English: The combination with strong CYP3A4 inhibitors should be avoided.
Slovenian: Kombinacijam z močnimi zaviralci CYP3A4 se je treba izogibati.
English: These effects were attributed to the inhibitory effect of felodipine in high doses on uterine contractility.
Slovenian: Te učinke so pripisali zaviralnemu učinku velikih odmerkov felodipina na krčljivost maternice.
English: • Haemodynamically significant cardiac valvular obstruction
Slovenian: • hemodinamsko pomembna zožitev srčnih zaklopk • dinamična obstrukcija iztoka iz srca
English: Table 1 Undesirable effects System organ class
Slovenian: Neželeni učinki Organski sistem
English: In cyclosporin-treated renal transplant recipients, felodipine reduces blood pressure and improves both the renal blood flow and the glomerular filtration rate.
Slovenian: Prejemnikom presajene ledvice, ki dobivajo ciklosporin, felodipin zniža krvni tlak ter jim izboljša ledvični pretok krvi in hitrost glomerulne filtracije.
English: Felodipine is extensively metabolised in the liver by cytochrome P450 3A4 (CYP3A4) and all identified metabolites are inactive.
Slovenian: Biotransformacija Felodipin se v jetrih obsežno presnovi s citokromom P450 3A4 (CYP3A4) in vsi ugotovljeni presnovki so neaktivni.
English: If you have liver problems The level of felodipine in your blood may be increased.
Slovenian: Koncentracija felodipina v krvi se lahko poveča.