FrancophonIA/ELRC3.0 huggingface dataset:
English: Based on preclinical studies, acceptable light intensity for the balloon/diffuser combination ranges from 175-270 mW/cm of diffuser.
Bulgarian: Na podlagi predkliničnih raziskav se sprejemljiva jakost svetlobe za kombinacijo balona/difuzorja uvršča med 175 in 270 mW/cm difuzorja.
English: Pinnacle Biologics B.V. p/a Trust Company Amsterdam B.V.
Bulgarian: Z ZDRAVILOM Pinnacle Biologics B.V. p/a Trust Company Amsterdam B.V.
English: There may be an increase in the risk of thrombo-embolic events especially in patients with prolonged immobilization, post major surgery and other thromboembolic risk factors.
Bulgarian: Pojavi se lahko povečano tveganje tromboembolije, še posebej pri bolnikih z dolgotrajno imobilizacijo, po večji operaciji in pri ostalih faktorjih tveganja za tromboembolijo.
English: You may need to read it again If you have any further questions, please ask your doctor or pharmacist.
Bulgarian: - Če imate dodatna vprašanja, se posvetujte z zdravnikom ali farmacevtom.
English: In addition, an updated RMP should be submitted:
Bulgarian: tega je treba posodobljen RPM oddati v naslednjih primerih:
English: The photosensitivity reactions occurred primarily on the face, hands, and neck regions, which are the areas of the skin that are most susceptible to accidental sunlight exposure.
Bulgarian: Preobčutljivostne reakcije na svetlobo so se pojavile najprej na obrazu, rokah in v predelu vratu, tj. na področjih kože, ki so najbolj občutljiva za naključno izpostavljenost sončni svetlobi.
English: There is no information on overdose of PhotoBarr.
Bulgarian: Ni podatkov o prevelikem odmerjanju PhotoBarra.
English: A study investigating pharmacodynamic interactions has demonstrated that corticosteroids given before or concomitant with PDT to decrease formation of strictures may decrease the safety of treatment.
Bulgarian: Raziskava, ki je preučevala farmakodinamične interakcije, je pokazala, da lahko uporaba kortikosteroidov, ki se dajejo pred PDT ali sočasno z njim, da bi zmanjšali nastanek zoženja, zmanjša
English: The majority of these was mild to moderate in intensity and could be managed through 1-2 dilatations.
Bulgarian: Večina teh pojavov je bila blage do zmerne stopnje in jih je bilo mogoče odpraviti v 1-2 razširitvah (dilatacijah).
English: No pharmacokinetic and safety data in patients with hepatic impairment are available.
Bulgarian: Na razpolago ni nobenih farmakokinetičnih podatkov in podatkov o varnosti za bolnike z okvaro jeter.
English: PhotoBarr is not recommended for use in children below age 18 years due to a lack of data on safety and efficacy.
Bulgarian: Uporabe zdravila PhotoBarr pri otrocih, mlajših od 18 let, ni mogoče priporočiti zaradi nezadostnih podatkov o varnosti in učinkovitosti v tej starostni skupini.
English: Illumination of the target area with 630 nm wavelength laser light constitutes the second stage of therapy.
Bulgarian: Osvetlitev ciljnega področja z lasersko svetlobo valovne dolžine 630 nm predstavlja drugo fazo zdravljenja.
English: Porfimer sodium was not mutagenic in standard genotoxicity tests in the absence of light.
Bulgarian: Porfimer-natrij ni bil mutagen v običajnih raziskavah genotoksičnosti v odsotnosti svetlobe.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER
Bulgarian: IME IN NASLOV IMETNIKA DOVOLJENJA
English: Approximately 40-50 hours after PhotoBarr administration, light should be delivered by a fibre optic diffuser passed through the central channel of a centring balloon.
Bulgarian: Približno 40-50 ur po dajanju PhotoBarra je potrebna osvetlitev z difuzorjem z optičnimi vlakni, ki poteka skozi osrednji kanal balona za centriranje.
English: Sufficient vials of PhotoBarr should be reconstituted to provide the patient with a dose of 2 mg/kg.
Bulgarian: Pripraviti je treba zadostno število vial PhotoBarra, da se bolniku zagotovi odmerek 2 mg/kg.
English: If patients travel to a different geographical area with greater sunshine, they should retest their level of photosensitivity.
Bulgarian: Če bolniki potujejo v drugo geografsko območje, kjer je veliko sončne svetlobe, morajo ponovno preskusiti svojo stopnjo občutljivosti na svetlobo.
English: Required power output from diffuser a
Bulgarian: Zahtevana izhodna moč iz difuzorja a
English: The more active lifestyle of the healthy and relatively younger subjects compared with cancer patients may have been a contributing factor to these photosensitivity reactions.
Bulgarian: Aktivnejši način življenja zdravih in sorazmerno mladih bolnikov v primerjavi z rakavimi bolniki je morda dejavnik, ki prispeva k omenjenim
English: Available treatment and surveillance guidelines should be considered.
Bulgarian: Upoštevati je treba razpoložljivo zdravljenje in navodila za spremljanje bolnika.
English: An occurrence rate of 12% for oesophageal strictures was observed during the first course of treatment.
Bulgarian: Opažena je bila 12% pogostost pojavljanja striktur požiralnika v prvi fazi zdravljenja.
English: Direct sunlight: Before you go to receive your PhotoBarr injection, check that there are adequate shades and curtains in your home to keep out bright sunlight.
Bulgarian: Neposredna sončna svetloba: Preden greste po injekcijo PhotoBarra, se prepričajte, da so v vašem domu nameščeni ustrezni senčniki in zavese, ki vas ščitijo pred močno sončno svetlobo.
English: • CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE IMPOSED ON THE MARKETING AUTHORISATION HOLDER
Bulgarian: POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE, PREDPISANI IMETNIKU Izdaja zdravila je le pod omejenimi pogoji
English: − Healthcare professionals should be aware of side effects that may arise during or shortly after treatment, and how to treat them.
Bulgarian: − Zdravstveno osebje se mora zavedati možnih neželenih učinkov, ki se lahko pojavijo med ali kmalu po zdravljenju, ter kako ukrepati, če se neželeni učinki
English: affects 1 to 10 users in 10,000
Bulgarian: prizadene 1 do 10od 10.000 bolnikov
English: The first stage of PDT is the slow intravenous injection of PhotoBarr.
Bulgarian: Prva stopnja PDT je počasno intravensko injiciranje PhotoBarra.
English: If you go on holiday to an area with more sunshine, remember to repeat the skin test, especially if some areas of skin have not been exposed to sunlight since your PhotoBarr treatment.
Bulgarian: Če greste na dopust v kraje z več sončne svetlobe, ne pozabite ponoviti kožnega preskusa, še zlasti, če nekateri predeli kože niso bili izpostavljeni sončni svetlobi od vašega zdravljenja s PhotoBarrom dalje.
English: Safety and efficacy in patients with treatment failure of other local mucosal ablative therapy has not been evaluated.
Bulgarian: Varnosti in učinkovitosti pri bolnikih z neuspelim zdravljenjem z lokalno ablativno terapijo sluznice nismo ocenjevali.
English: The formation of oesophageal stenosis cannot be reduced or eliminated by the use of steroids.
Bulgarian: Uporaba steroidov ne more zmanjšati ali preprečiti nastajanja stenoze.
English: Porfimer sodium is not dialyzable.
Bulgarian: Porfimer-natrij ni primeren za dializo.
English: The laser treatment induces a photochemical, not a thermal, effect.
Bulgarian: ima za posledico fotokemični, ne pa tudi toplotnega učinka.
English: Patients older than 75 years may be at a higher risk of respiratory related adverse events such as pleural effusion and dyspnoea.
Bulgarian: Bolniki, starejši od 75 let, so morda bolj ogroženi, kar zadeva neželene učinke, povezane z dihanjem, kot so plevralni izliv in dispneja.
English: Patients were followed every 3 months until 4 consecutive, quarterly follow-up endoscopic biopsy results were negative for HGD, and then biannually until the last enrolled patient had completed a minimum of 24 months of follow-up evaluations after randomisation.
Bulgarian: so opravili kontrolne preglede vsake 3 mesece, dokler niso bili rezultati endoskopske biopsije 4 zaporednih četrtletnih kontrolnih pregledov negativni za HGD, nato pa dvakrat letno, dokler ni zadnji bolnik, vključen v raziskavo, zaključil najmanj 24-mesečnega obdobja kontrolnih ocen po
English: Also, treating physicians should be aware of the possibility of squamous overgrowth and the risk of overlooking cancer.
Bulgarian: Poleg tega se morajo lečeči zdravniki zavedati možnosti bujnega razraščanja ploščatega epitelija in nevarnosti, da spregledajo raka.
English: Plasma samples were obtained out to 56 days (patients) or 36 days (volunteers) post-injection.
Bulgarian: Krvne vzorce so dobili do 56 dni (bolniki) ali 36 dni (prostovoljci) po
English: Photoactivation
Bulgarian: Fotoaktivacija
English: It is possible that prolonged exposure to light at the clinical research unit or accidental sunlight exposure after discharge may be responsible for the high frequency of photosensitivity reactions.
Bulgarian: Možno je, da daljša izpostavljenost svetlobi na oddelku za klinične raziskave ali naključna izpostavljenost sončni svetlobi po sprostitvi povzroči večjo pogostost fotosenzitivnih reakcij.
English: All patients who receive PhotoBarr will be photosensitive and must observe precautions to avoid sunlight and bright indoor light (see section 4.4).
Bulgarian: Vsi bolniki, ki dobivajo PhotoBarr, so občutljivi na svetlobo in morajo upoštevati previdnostne ukrepe, da se izognejo sončni svetlobi in močni notranji svetlobi (glejte poglavje 4.4).
English: remember to take protective clothing and sunglasses with you to your appointment, as you will be photosensitive once the injection has been given.
Bulgarian: ne pozabite vzeti k zdravniku zaščitnih oblačil in sončnih očal, ker boste po aplikaciji injekcije
English: Data on the long-term effect of PhotoBarr (beyond two years) are not available at the moment.
Bulgarian: Podatki o dolgotrajnem učinku PhotoBarra (več kot dve leti)
English: Acute hypersensitivity reactions including anaphylaxis have been reported.
Bulgarian: Poročali so o akutnih preobčutljivostnih reakcijah, vključno z anafilaksijo.
English: The medicinal product should only be administered when material and personnel experienced in evaluating and treating anaphylaxis are immediately available.
Bulgarian: Zdravilo dajemo le takrat, ko je na voljo material in osebje, izkušeno v ocenjevanju in zdravljenju anafilaksije.
English: Clearance from a variety of tissues occurs over 40-72 hours, but tumours, skin, and organs of the reticuloendothelial system (including liver and spleen) retain porfimer sodium for a longer period.
Bulgarian: Očistek v različnih tkivih se pojavi po 40-72 urah, vendar pa porfimer-natrij dalj časa ostane v tumorjih, koži in organih retikuloendotelijskega sistema (vključno z jetri in vranico).
English: It is not known whether porfimer sodium is excreted into human breast milk.
Bulgarian: Ni znano, ali se porfimer-natrij izloča v materino mleko.
English: Note: No more than 1.5 times the required diffuser power output should be needed from the laser.
Bulgarian: Opomba: Potrebna je največ 1,5-kratna zahtevana izhodna moč razpršitve svetlobe iz laserja.
English: PhotoBarr should be administered as a single slow intravenous injection over 3 to 5 minutes.
Bulgarian: PhotoBarr je treba dajati kot enkratno počasno intravensko injekcijo 3 do 5 minut.
English: The most frequently reported treatment-associated serious adverse reaction (SAR) was dehydration (4%), experienced by 5 patients.
Bulgarian: Huda neželena reakcija (HNR), o kateri so najpogosteje poročali kot o posledici zdravljenja, je bila dehidracija (4%), ki je bila prisotna pri 5 bolnikih.
English: − It is important to have an appropriate light dose and a proper setting for the laser.
Bulgarian: − Pomembno je, da je osvetlitev ustrezno odmerjena in da so nastavitve laserja pravilne.
English: Patients should not drive or use machines after the light treatment if they have been sedated for the procedure.
Bulgarian: smejo upravljati vozil ali strojev po zdravljenju s svetlobo, če so bili pri postopku sedirani.
English: Very rare:
Bulgarian: Zelo redko:
English: PhotoBarr PDT regularly causes dysphagia, odynophagia, nausea and vomiting.
Bulgarian: PhotoBarr PDT redno povzroča disfagijo, odinofagijo, slabost in bruhanje.
English: A second laser light application may be given to a previously treated segment that shows a 'skip' area, (i.e., an area that does not show sufficient mucosal response) using a short < 2.5 cm fibre optic diffuser at the light dose of 50 J/cm of diffuser length (see Table 3).
Bulgarian: Prej zdravljenemu segmentu se lahko doda druga uporaba laserske svetlobe, ki kaže »izpuščeno« področje (tj. področje, ki ne kaže zadostnega odziva sluznice pri uporabi < 2,5 cm difuzorja z kratkimi optičnimi vlakni pri odmerku svetlobe 50 J/cm dolžine difuzorja (glejte Preglednico 3).
English: affects less than 1 user in 10,000
Bulgarian: prizadene manj kot 1 od 10.000 bolnikov
English: Method of administration For instructions on reconstitution prior to administration, see section 6.6
Bulgarian: Postopek uporabe Pred uporabo preberite navodila za pripravo, glejte poglavje 6.6
English: Before exposing any area of skin to direct sunlight or bright indoor light, the patient should test it for residual photosensitivity.
Bulgarian: Pred izpostavitvijo katerega koli dela kože neposredni sončni svetlobi ali močni svetlobi v prostoru, mora bolnik preizkusiti rezidualno občutljivost na svetlobo.
English: Short (< 2.5 cm) fibre optic diffuser (50 J/cm)
Bulgarian: s kratkimi (< 2,5 cm) optičnimi vlakni (50 J/cm)
English: - Suspected erosion of major blood vessels due to risk of massive, potentially fatal haemorrhage.
Bulgarian: - Sum za razjedo velikih krvnih žil zaradi nevarnosti masivne, potencialno usodne krvavitve.
English: Radical initiation may occur after porfimer sodium absorbs light to form a porphyrin excited state.
Bulgarian: Nastajanje radikalov se lahko pojavi po tem, ko porfimer-natrij absorbira svetlobo, da nastane povečano stanje porfirina.
English: Check for the appearance of red marks, swelling or blistering after one day.
Bulgarian: Po enem dnevu preverite, ali so se pojavila rdeča znamenja, oteklina ali mehurčki.
English: − You should not be treated with PhotoBarr if you have severe liver disease (eg
Bulgarian: − Zdravljenja s PhotoBarrom ne smete prejemati, če imate hudo okvaro jeter (npr.
English: Table 3.
Bulgarian: Preglednica 3.
English: If accidentally injected paravenously there may be damage to paravenous tissue.
Bulgarian: Če se pomotoma vbrizga v okolico vene, lahko poškoduje okoliško tkivo.
English: o all patients should know that UV blocking is not effective in blocking visible light which activates porfimer.
Bulgarian: o Vsi bolniki se morajo poučiti o tem, da UV-zaščita nima zaščitnega delovanja pri vidni svetlobi, s kakršno se porfirini aktivirajo.
English: The choice of fibre optic/balloon diffuser combination will depend on the length of oesophagus to be treated (Table 1).
Bulgarian: Izbira kombinacije difuzorja z optičnimi vlakni/balona je odvisna od dolžine požiralnika, ki jo je treba zdraviti (Preglednica 1).
English: Do not use PhotoBarr after the expiry date which is stated on the carton and vial after EXP.
Bulgarian: PhotoBarra ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatlici in viali za oznako EXP.
English: In the event of an overdose, patients should protect their eyes and skin from direct sunlight or bright indoor lights for 90 days.
Bulgarian: V primeru dajanja prevelikih odmerkov, si morajo bolniki za 90 dni zaščititi oči in kožo pred neposredno sončno svetlobo ali močno zunanjo svetlobo.
English: Photodynamic therapy with PhotoBarr should be applied by physicians trained in endoscopic use of PDT and only in those facilities properly equipped for the procedure.
Bulgarian: s PhotoBarrom naj uporabijo le zdravniki, ki so usposobljeni za endoskopsko uporabo PDT in le v tistih ustanovah, ki so
English: PhotoBarr is a light-activated medicine used photodynamic therapy (PDT)in combination with a non-burning, red laser light.
Bulgarian: PhotoBarr je zdravilo, ki ga aktivira svetloba, in se uporablja za fotodinamično zdravljenje (PDT) (photodynamic therapy) v kombinaciji z rdečo nevročo lasersko svetlobo.
English: In an open label pharmacokinetic study, all 24 healthy subjects experienced photosensitivity reactions, which were characteristically represented by erythematous rash and oedema and were mild to moderate in intensity.
Bulgarian: V odprti farmakokinetični raziskavi je imelo vseh 24 zdravih prostovoljcev preobčutljivostne reakcije na svetlobo, za katere je bil značilen eritematozni izpuščaj in edem blage do zmerne stopnje.
English: Pneumonia
Bulgarian: Pljučnica
English: Reconstituted PhotoBarr solution (ml) = Patient's weight (kg) x 2 mg/kg = 0.8 x patient's weight
Bulgarian: Rekonstituirana raztopina PhotoBarra (ml) = bolnikova masa (kg) x 2 mg/kg = 0,8 x bolnikova masa
English: PhotoBarr injection: You will receive one intravenous injection of PhotoBarr (2 mg per kg of body weight) 40 to 50 hours before laser light treatment.
Bulgarian: Injiciranje zdravila PhotoBarr: Prejeli boste eno intravensko injekcijo PhotoBarra (2 mg na kg telesne mase) 40 do 50 ur pred zdravljenjem z lasersko svetlobo.
English: Nutrition in Patients
Bulgarian: Prehrana pri bolnikih
English: Spills of PhotoBarr should be wiped up with a damp cloth.
Bulgarian: Razlit PhotoBarr obrišite z vlažno krpo.
English: The MAH commits to performing the studies and additional pharmacovigilance activities detailed in the Pharmacovigilance Plan, as agreed in version 2 of the Risk Management Plan (RMP) presented in Module 1.8.2. of the Marketing Authorisation Application and any subsequent updates of the RMP agreed by the CHMP.
Bulgarian: Načrt upravljanja tveganja (RMP, risk management plan) Imetnik dovoljenja za promet se zavezuje k izvajanju raziskav in drugih dejavnosti za spremljanje farmakovigilance, podrobno opredeljenih v načrtu farmakovigilance, kot narekuje različica RMP 2, predstavljena v modulu prijave v postopek za pridobivanje dovoljenja zdravila 1.8.2.
English: At this time, patients should test for residual photosensitivity (see section 4.4).
Bulgarian: V tem času je treba na bolnikih opraviti preskus glede rezidualne občutljivosti na svetlobo (glejte poglavje 4.4).
English: Exposure of the skin to ambient indoor light is, however, beneficial because the remaining medicinal product will be inactivated gradually through a photobleaching reaction.
Bulgarian: Izpostavljenost kože okoliški svetlobi na prostem je vsekakor koristna, ker se preostanek medicinskega izdelka postopno deaktivira
English: A maximum of 7 cm of Barrett's mucosa is treated at the first light session using an appropriate size of centering balloon and fibre optic diffuser (Table 1).
Bulgarian: s svetlobo se zdravi največ 7 cm sluznice Barrettovega požiralnika z uporabo primerne velikosti balona za centriranje in difuzorja z optičnimi vlakni (Preglednica 1).
English: Keep the vial in the outer carton in order to protect from light.
Bulgarian: Vialo hranite v zunanji ovojnini, da jo zaščitite pred svetlobo.
English: HOW TO STORE PHOTOBARR Keep out of the reach and sight of children.
Bulgarian: SHRANJEVANJE ZDRAVILA PHOTOBARR Zdravilo shranjujte zunaj dosega in pogleda otrok.
English: The mean elimination half-life (t1/2) was 21.5 days (CV 26 %, range 264-672) in patients and 17 days in volunteers.
Bulgarian: Srednja razpolovni čas izločanja (t1/2) je bila pri bolnikih 21,5 dni (CV 26%, razpon 264-672) in pri prostovoljcih 17 dni.
English: The occurrence rate rose to 32% when a second course of therapy was given, especially in the areas where second treatment overlaps the first and amounted to 10% for those who received a third treatment course.
Bulgarian: Pogostost pojavljanja se je povečala na 32% po drugi fazi zdravljenja, zlasti v predelih, kjer se drugo zdravljenje prekriva
English: The light dose administered will be 130 Joules/cm (J/cm) of diffuser length using a centring balloon.
Bulgarian: Uporabljeni odmerek svetlobe je 130 joulov/cm (J/cm) dolžine difuzorja z uporabo balona za centriranje.
English: You will be given a sedative along with a local anaesthetic to minimise discomfort.
Bulgarian: Za zmanjšanje nelagodja boste dobili pomirjevalo skupaj z lokalnim anestetikom.
English: Elderly
Bulgarian: Starejši
English: After it has been reconstituted, PhotoBarr should be used immediately (within 3 hours) and protected from light.
Bulgarian: Po pripravi je treba PhotoBarr takoj uporabiti (v 3 urah) in ga zaščititi pred svetlobo.
English: Other exclusion criteria were patients in whom omeprazole therapy was contraindicated.
Bulgarian: Drugi kriteriji za izločitev so bili bolniki, pri katerih je bilo zdravljenje z omeprazolom kontraindicirano.
English: − Patients should be warned of the possibility of long term side effects, especially photosensitivity, and the need to seek medical assistance if they arise.
Bulgarian: − Bolnike je treba opozoriti na možnost dolgotrajnih neželenih učinkov, posebno preobčutljivosti na svetlobo, in poučiti, da v takih primerih poiščejo zdravstveno
English: Spin transfer from porfimer sodium to molecular oxygen may then generate singlet oxygen.
Bulgarian: Sučni prenos od porfimer-natrija do molekulskega kisika lahko nato proizvede kisik singlet.
English: Patients who received one course of PDT had a greater risk of progression to cancer than patients who received two or three courses of PDT (50% vs. 39% and 11% respectively)
Bulgarian: tveganje razvoja raka večje kot pri bolnikih, ki so prejeli 2 ali 3 epizode PDT (50% proti 39 oz.
English: The most frequently reported adverse reactions were photosensitivity reactions (69%), oesophageal stenosis (40%), vomiting (32%), chest pain of non-cardiac origin (20%), pyrexia (20%), dysphagia (19%), constipation (13%), dehydration (12%) and nausea (11%).
Bulgarian: Najpogostejši opaženi neželeni učinki so bile preobčutljivostne reakcije na svetlobo (69%), ezofagealna stenoza (40%), bruhanje (32%), bolečina v prsih, ki ni povezana s srcem/ki nima izvora v srcu (20%), pireksija (20%), disfagija (19%), zaprtje (13%), dehidracija (12%) in slabost (11%).
English: cover as much skin as possible by wearing a long-sleeved shirt, trousers, socks, shoes, gloves and a wide brimmed hat protect your eyes with dark sunglasses.
Bulgarian: srajco z dolgimi rokavi, hlače, nogavice, čevlje, rokavice in širokokrajni klobuk, oči si zavarujte
English: Procedure
Bulgarian: Za postopek
English: All patients who receive PhotoBarr will be photosensitive and must observe precautions to avoid exposure of skin and eyes to direct sunlight or bright indoor light (from examination lamps, including dental lamps, operating room lamps, unshaded light bulbs at close proximity, neon lights, etc.) for at least 90 days after treatment, as some patients may remain photosensitive for up to 90 days or more.
Bulgarian: Vsi bolniki, ki dobivajo PhotoBarr, so občutljivi na svetlobo in morajo upoštevati posebna opozorila, da se izognejo izpostavljenosti kože in oči neposredni sončni svetlobi ali močni notranji svetlobi (svetilke za opazovanje, vključno z zobozdravstvenimi svetilkami, lučmi v operacijskih dvoranah, nezasenčenimi žarnicami v neposredni bližini, neonskimi lučmi itd.), najmanj 90 dni po zdravljenju, ker lahko nekateri bolniki ostanejo občutljivi na svetlobo še do 90 dni ali več.
English: Any unused product or waste material should be disposed of in accordance with local requirements.
Bulgarian: Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
English: The majority of treatment-associated oesophageal stenosis (which includes oesophageal narrowing and oesophageal strictures) reported in the PhotoBarr PDT + OM group were of mild or moderate intensity (92%).
Bulgarian: Večina stenoz požiralnika, povezanih z zdravljenjem (ki vključuje zoženje in strikture požiralnika), o katerih so poročali v skupini, ki je dobivala PhotoBarr PDT + OM, je bila blagih do srednje hudih (92%).
English: Preclinical data also suggest that tissue ischaemia, allopurinol, calcium channel blockers and some prostaglandin synthesis inhibitors could interfere with PhotoBarr PDT.
Bulgarian: Predklinični podatki prav tako kažejo na ishemijo tkiva, alopurinol, blokatorji kalcijevih kanalčkov in nekateri zaviralci sinteze prostaglandina pa bi lahko vplivali na zdravljenje