FrancophonIA/ELRC3.0 huggingface dataset:
English: Outcomes by prior treatment experience are presented in Table 11.
Croatian: Ishodi prema prethodnom terapijskom iskustvu prikazani su u Tablici 11.
English: All patients receiving Daklinza and sofosbuvir in combination with amiodarone with or without other drugs that lower heart rate should also be warned of the symptoms of bradycardia and heart block and should be advised to seek medical advice urgently should they experience them.
Croatian: Sve bolesnike koji primaju lijek Daklinza i sofosbuvir u kombinaciji s amiodaronom s ili bez drugih lijekova koji snižavaju frekvenciju srca treba također upozoriti na simptome bradikardije i srčanog bloka te ih treba savjetovati da hitno potraže liječnički savjet ukoliko osjete iste.
English: ≤30 mL/min or haemodialysis
Croatian: ≤30 ml/min ili hemodijaliza
English: Mainly interferon-based therapy, but 7 patients received sofosbuvir + ribavirin and 2 patients received a cyclophilin inhibitor.
Croatian: Pretežno terapija temeljena na interferonu, ali 7 bolesnika je primilo sofosbuvir + ribavirin te su 2 bolesnika primila inhibitor ciklofilina.
English: With some of these medicines, your doctor may need to adjust your dose of Daklinza.
Croatian: Uz primjenu nekog od ovih lijekova Vaš liječnik će morati prilagoditi dozu lijeka Daklinza.
English: At the highest dose (100 mg/kg/day), maternal toxicity included mortality and dystocia; developmental toxicity included slight reductions in offspring viability in the peri- and neonatal periods; and reductions in birth weight that persisted into adulthood.
Croatian: Pri najvišoj je dozi (100 mg/kg na dan) toksičnost za majku uključivala smrtnosti i distociju; razvojna toksičnost uključivala je blaga smanjenja vijabilnosti potomstva u perinatalnom i neonatalnom razdoblju te smanjenje tjelesne težine pri okotu, koja je ostala smanjena i u odrasloj dobi.
English: 200 mg every other day
Croatian: 200 mg svaki drugi dan
English: The Cmax and AUC of total daclatasvir (free and protein-bound drug) were lower in subjects with hepatic impairment; however, hepatic impairment did not have a clinically significant effect on the free drug concentrations of daclatasvir (see section 4.2).
Croatian: Cmax i AUC ukupnog daklatazvira (slobodnog i vezanog za proteine) bili su niži u ispitanika s oštećenjem jetrene funkcije; međutim, oštećenje jetrene funkcije nije imalo klinički značajnog učinka na koncentracije slobodnog daklatazvira (vidjeti dio 4.2).
English: Population pharmacokinetic analysis of data from clinical studies indicated that age had no apparent effect on the pharmacokinetics of daclatasvir.
Croatian: Populacijska farmakokinetička analiza podataka iz kliničkih ispitivanja pokazala je da dob nema vidljivog učinka na farmakokinetiku daklatazvira.
English: In limited numbers of genotype 4-infected patients with non-response, substitutions L28M and L30H/S were detected at failure.
Croatian: U ograničenog broja bolesnika s infekcijom genotipom 4 koji nisu odgovorili na terapiju, zamjene L28M i L30H/S su primjećene kod neuspjeha liječenja.
English: Discontinue peginterferon alfa and ribavirin (treatment with Daklinza is complete at week 24)
Croatian: Isključiti peginterferon alfa i ribavirin (liječenje lijekom Daklinza je završeno u 24. tjednu)
English: Tell your doctor if any of the following applies: you currently take, or have taken in the last few months, the medicine amiodarone to treat irregular heartbeats (your doctor may consider alternative treatments if you have taken this medicine) you have a current or previous infection with the hepatitis B virus, since your doctor may want to monitor you more closely your liver is damaged and not functioning properly (decompensated liver disease)
Croatian: trenutno uzimate, ili ste u posljednjih nekoliko mjeseci uzimali lijek amiodaron za liječenje nepravilnih otkucaja srca (Vaš liječnik može razmotriti zamjensko liječenje ako ste uzimali ovaj lijek) imate ili ste prethodno imali infekciju virusom hepatitisa B jer će Vas liječnik možda htjeti pobliže pratiti jetra
English: 12 weeks therapy
Croatian: 12 tjedana terapije
English: The film-coated tablet should not be chewed or crushed due the unpleasant taste of the active substance.
Croatian: Filmom obložena tableta ne smije se žvakati niti drobiti jer djelatna tvar ima neugodan okus.
English: Patients with HCV infection (across genotypes) at high risk of decompensation or death within 12 months if left untreated were treated under compassionate use programmes.
Croatian: Bolesnici s infekcijom HCV-om (svih genotipova) s visokim rizikom od dekompenzacije ili smrti unutar 12 mjeseci u slučaju neliječenja, liječeni su u okviru programa milosrdnog davanja lijeka.
English: Elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate
Croatian: elvitegravir, kobicistat, emtricitabin, tenofovir dizoproksil fumarat
English: In rats, no effect on mating or fertility was seen (see section 5.3).
Croatian: U štakora nije zamijećen utjecaj na parenje ili plodnost. (vidjeti dio 5.3).
English: Creatinine Clearance >50 mL/min
Croatian: Klirens kreatinina >50 ml/min
English: If you take any of these medicines, tell your doctor immediately.
Croatian: Ako uzimate neki od tih lijekova, odmah o tome obavijestite svog liječnika.
English: Coadministration of medicines that inhibit P-gp or OCT1 activity is likely to have a limited effect on daclatasvir exposure.
Croatian: Istodobna primjena s lijekovima koji inhibiraju aktivnost P-gp-a ili OCT1 mogla bi imati ograničen učinak na izloženost daklatazviru.
English: In rats, malformations mainly affected the brain, skull, eyes, ears, nose, lip, palate or limbs and in rabbits, the ribs and cardiovascular area.
Croatian: U štakora malformacije su uglavnom zahvaćale mozak, lubanju, oči, uši, usne, nepce ili udove, a u kunića rebra i kardiovaskularno područje.
English: Caution should be used if the medicinal product has a narrow therapeutic range (see Table 4).
Croatian: Potreban je oprez ako lijek ima uzak terapijski raspon (vidjeti Tablicu 4).
English: Daklinza should not be used during pregnancy or in women of childbearing potential not using contraception.
Croatian: Daklinza se ne smije uzimati u trudnoći niti u žena reproduktivne dobi koje ne koriste kontracepciju.
English: Daklinza contains lactose
Croatian: Daklinza sadrži laktozu
English: Response was rapid (viral load at Week 4 showed that more than 95% of patients responded to therapy) and was not influenced by IL28B genotype.
Croatian: Odgovor je bio brz (virusno opterećenje u 4. tjednu je pokazalo da je više od 95% bolesnika odgovorilo na terapiju) te nije bio pod utjecajem IL28B genotipa.
English: Four patients discontinued the Daklinza regimen for adverse events, only one of which was considered related to study therapy.
Croatian: Četiri su bolesnika prekinula liječenje režimom koji je uključivao lijek Daklinza zbog nuspojava, od kojih se samo jedna smatrala povezanom s ispitivanom terapijom.
English: Azithromycin Ciprofloxacin
Croatian: azitromicin ciprofloksacin
English: Not all packages may be marketed in your country.
Croatian: Na tržištu u Vašoj zemlji ne moraju se nalaziti sve veličine pakiranja.
English: Treatment week 4: >1000 IU/ml
Croatian: 4. tjedan liječenja : >1000 IU/ml
English: Cases are potentially life threatening, therefore amiodarone should only be used in patients on Daklinza and sofosbuvir when other alternative antiarrhythmic treatments are not tolerated or are contraindicated.
Croatian: Slučajevi su potencijalno opasni po život, stoga se amiodaron smije koristiti samo u bolesnika koji primaju lijek Daklinza i sofosbuvir u slučajevima kada se drugi zamjenski antiaritmici ne podnose ili su kontraindicirani.
English: * Evaluated in opioid-dependent adults on stable methadone maintenance therapy.
Croatian: * Ocijenjeno u odraslih osoba ovisnih o opioidima koje su primale stabilnu terapiju održavanja metadonom.
English: The most frequently reported adverse reactions of at least Grade 3 severity (frequency of 1% or greater) were neutropenia, anaemia, lymphopenia and thrombocytopenia.
Croatian: Najčešće prijavljene nuspojave najmanje 3. stupnja težine (učestalost: 1% ili više) bile su neutropenija, anemija, limfopenija i trombocitopenija.
English: SEDATIVES
Croatian: SEDATIVI
English: The most frequently reported adverse reactions were fatigue, headache, and nausea.
Croatian: Najčešće prijavljene nuspojave bile su umor, glavobolja i mučnina.
English: The dose of daclatasvir was 60 mg once daily, with dose adjustments for concomitant antiretroviral use (see section 4.5).
Croatian: Doza daklatazvira bila je 60 mg jedanput na dan s prilagodbom doze kod istodobne primjene antiretrovirusnih lijekova (vidjeti dio 4.5).
English: >30 to ≤50 mL/min
Croatian: >30 i ≤50 ml/min
English: SVR12 was achieved by 99% patients with HCV genotype 1, 96% of those with genotype 2 and 89% of those with genotype 3 (see Tables 6 and 7).
Croatian: SVR12 je postiglo 99% bolesnika s HCV-om genotipa 1, 96% bolesnika s genotipom 2 i 89% onih s genotipom 3 (vidjeti Tablice 6 i 7).
English: If you have been told by your doctor that you have an intolerance to some sugars (e.g. lactose), talk to your doctor before taking Daklinza.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke šećere (npr. laktozu), savjetujte se s njime prije uzimanja lijeka Daklinza.
English: The dose of daclatasvir was adjusted for concomitant antiretroviral use.
Croatian: Doza daklatazvira prilagođavala se prema istodobno primjenjenim antiretrovirusnim lijekovima.
English: It may harm them, even if their signs of illness are the same as yours.
Croatian: AUC: 1,05 (1,03; 1,07) Cmax: 1,07 (1,02; 1,12) Cmin: 1,10 (1,03; 1,19)
English: Patients should be instructed that, if they miss a dose of Daklinza, the dose should be taken as soon as possible if remembered within 20 hours of the scheduled dose time.
Croatian: Propuštene doze Bolesnike treba uputiti da, zaborave li uzeti dozu lijeka Daklinza, propuštenu dozu trebaju uzeti što je prije moguće, pod uvjetom da je to unutar 20 sati od predviđenog vremena uzimanja.
English: The SVR12 rate in genotype-3 infected patients with this RAV is reduced (in practice as relapse after end of treatment response), especially in patients with cirrhosis.
Croatian: Stopa SVR12 smanjena je u bolesnika s infekcijom genotipom 3 koji imaju tu varijantu (u praksi se to manifestira kao relaps nakon odgovora na kraju liječenja), osobito u bolesnika s cirozom.
English: In male rats, effects on reproductive endpoints were limited to reduced prostate/seminal vesicle weights, and minimally increased dysmorphic sperm at 200 mg/kg/day; however, neither finding adversely affected fertility or the number of viable conceptuses sired.
Croatian: U mužjaka štakora su učinci na reproduktivni sustav bili ograničeni na smanjenu težinu prostate/sjemenih mjehurića te minimalno povećan broj morfološki deformiranih spermija pri dozi od 200 mg/kg/dan; međutim, ni jedno ni drugo nije štetno utjecalo na plodnost niti na broj začetih vijabilnih zametaka.
English: Daklinza should not be used during pregnancy or in women of childbearing potential not using contraception (see section 4.4).
Croatian: Daklinza se ne smije primjenjivati tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju (vidjeti dio 4.4.).
English: The most frequently detected NS5A RAVs included Q30E or Q30R in combination with L31M.
Croatian: NS5A koje su povezane s rezistencijom uključivale su Q30E ili Q30R u kombinaciji s L31M.
English: Do not use this medicine after the expiry date which is stated on the carton and blister after "EXP".
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake "EXP" ili "Rok valjanosti".
English: ↑ Concentration of statin
Croatian: ↑ koncentracija statina
English: There are no data from the use of daclatasvir in pregnant women.
Croatian: Nema podataka o primjeni daklatazvira u trudnica.
English: The efficacy of Daklinza as part of a retreatment regimen in patients with prior exposure to a NS5A inhibitor has not been established.
Croatian: Djelotvornost lijeka Daklinza kao dijela režima ponovnog liječenja u bolesnika prethodno izloženih NS5A inhibitorima nije dokazana.
English: The median viral load was 6.42 log10 IU/ml, and 21% of patients had compensated cirrhosis.
Croatian: Medijan virusnog opterećenja bio je 6,42 log10 IU/ml te je 21% bolesnika imalo kompenziranu cirozu.
English: When Daklinza is used together with sofosbuvir (without ribavirin), the following side effects have been reported.
Croatian: Kada se Daklinza uzima zajedno sa sofosbuvirom (bez ribavirina) prijavljene su sljedeće nuspojave.
English: At the 60 mg dose, exposure to daclatasvir was similar between healthy subjects and HCV-infected patients.
Croatian: Pri dozi od 60 mg, izloženost daklatazviru bila je slična među zdravim ispitanicima i bolesnicima s infekcijom HCV-om.
English: The active transport is mediated by OCT1 and other unidentified uptake transporters, but not by organic anion transporter (OAT) 2, sodium-taurocholate cotransporting polypeptide (NTCP), or OATPs.
Croatian: Aktivni prijenos posredovan je pomoću OCT1 i drugih neidentificiranih transportera preuzimanja, ali ne i pomoću organskog anionskog transportera (OAT) 2, natrij-taurokolat polipeptida (NTCP), ili
English: The safety and efficacy of Daklinza in children and adolescents aged below 18 years have not yet been established.
Croatian: Sigurnost i djelotvornost lijeka Daklinza u djece i adolescenata mlađih od 18 godina nisu još ustanovljene.
English: This medicine works by stopping the hepatitis C virus from multiplying and infecting new cells.
Croatian: Ovaj lijek djeluje tako da zaustavlja umnažanje virusa hepatitisa C i zaražavanje novih stanica.
English: Coadministration of Daklinza can alter the concentration of other medicinal products and other medicinal products may alter the concentration of daclatasvir.
Croatian: Istodobna primjena lijeka Daklinza može izmijeniti koncentracije drugih lijekova, a drugi lijekovi mogu izmijeniti koncentraciju daklatazvira.
English: All Genotype 2 N=26
Croatian: svi s genotipom 2 N=26
English: ANTIBACTERIALS Clarithromycin Telithromycin
Croatian: LIJEKOVI klaritromicin telitromicin
English: If treatment interruption of components in the regimen is necessary because of adverse reactions, Daklinza must not be given as monotherapy.
Croatian: Ako se primjena drugih lijekova u režimu mora privremeno prekinuti zbog nuspojava, Daklinza se ne smije davati u monoterapiji.
English: These substitutions conferred low level resistance (EC50 <1 nM) for genotype 1b, and higher levels of resistance for genotype 1a (EC50 up to 350 nM).
Croatian: Te su supstitucije uzrokovale rezistenciju niskog stupnja (EC50 < 1 nM) kod genotipa 1b te rezistenciju višeg stupnja kod genotipa 1a (EC50 do 350 nM).
English: Some patients have reported dizziness, difficulty concentrating, and vision problems while taking Daklinza with other medicines for their hepatitis C infection.
Croatian: Neki su bolesnici prijavili omaglicu, poteškoće s koncentracijom i tegobe s vidom tijekom liječenja lijekom Daklinza u kombinaciji s drugim lijekovima za liječenje infekcije hepatitisom C.
English: Total N=152
Croatian: Ukupno N=152
English: Cirrhosis status was not reported for four patients in the daclatasvir + pegIFN/RBV group.
Croatian: Status ciroze nije bio prijavljen za četiri bolesnika u skupini koja je primala daklatazvir + pegIFN/RBV.
English: The SVR rate for patients treated for 8 weeks was lower with this treatment duration as summarized in Table 11.
Croatian: Stopa SVR-a u bolesnika liječenih tijekom 8 tjedana bila je niža kod ovog trajanja liječenja, što je i sažeto prikazano u
English: Should concomitant use of amiodarone be considered necessary it is recommended that patients are closely monitored when initiating Daklinza in combination with sofosbuvir.
Croatian: Ako se istovremena primjena amiodarona smatra neophodnom, preporučuje se da se bolesnike pažljivo prati prilikom početka uzimanja lijeka Daklinza u kombinaciji sa sofosbuvirom.
English: In vitro and in vivo studies showed that daclatasvir is a substrate of P-gp.
Croatian: In vitro i in vivo ispitivanja pokazala su da je daklatazvir supstrat za P-gp.
English: All N=41
Croatian: svi N=41
English: Tell your doctor if you are pregnant, think you may be pregnant or are planning to become pregnant.
Croatian: Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete,obratite se svom liječniku.
English: Antiviral activity in cell culture
Croatian: Antivirusno djelovanje u staničnoj kulturi
English: Administration of Daklinza may increase systemic exposure to medicinal products that are substrates of P-gp, OATP 1B1, OCT1 or BCRP, which could increase or prolong their therapeutic effect and adverse reactions.
Croatian: Primjena lijeka Daklinza može povećati sistemsku izloženost lijekovima koji su supstrati za P-gp, OATP 1B1, OCT1ili BCRP, što može pojačati ili produljiti njihov terapijski učinak i nuspojave.
English: Strong inhibitors of CYP3A4 may increase the plasma levels of daclatasvir.
Croatian: Snažni inhibitori CYP3A4 mogu povećati razine daklatazvira u plazmi.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON TEXT
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU TEKST NA KUTIJI
English: 0.180/0.215/0.250 mg is recommended with Daklinza.
Croatian: 0,180/0,215/0,250 mg norgestimata s lijekom Daklinza.
English: *Comparison for daclatasvir was to a historical reference (data from 3 studies of daclatasvir 60 mg once daily with peginterferon alfa and ribavirin).
Croatian: *Usporedba za daklatazvir temelji se na podacima iz prethodnih ispitivanja (podaci iz 3 ispitivanja daklatazvira u dozi od 60 mg jedanput na dan u kombinaciji s peginterferonom alfa i ribavirinom).
English: All N=126
Croatian: svi N=126
English: Following multiple-dose administration of daclatasvir in HCV-infected patients, the terminal elimination half-life of daclatasvir ranged from 12 to 15 hours.
Croatian: Nakon primjene višestrukih doza daklatazvira u bolesnika s infekcijom HCV-om, terminalno poluvrijeme eliminacije daklatazvira kretalo se u rasponu od 12 do 15 sati.
English: Due to the long half-life of amiodarone, appropriate monitoring should also be carried out for patients who have discontinued amiodarone within the past few months and are to be initiated on Daklinza in combination with sofosbuvir.
Croatian: Zbog dugog poluvijeka amiodarona, treba također provesti odgovarajuće nadziranje bolesnika koji su prekinuli uzimanje amiodarona unutar nekoliko posljednjih mjeseci, a započet će terapiju lijekom
English: The most resistant variants with single amino acid substitution in genotype 2a and genotype 3a were F28S (EC50 >300 nM) and Y93H (EC50 >1,000 nM), respectively.
Croatian: Najrezistentnije varijante sa samo jednom aminokiselinskom zamjenom u genotipu 2a odnosno genotipu 3a bile su F28S (EC50 > 300 nM) odnosno Y93H (EC50 >1000 nM).
English: The efficacy and safety of daclatasvir 60 mg once daily in combination with sofosbuvir 400 mg once daily in the treatment of patients with chronic HCV infection were evaluated in four open-label studies (AI444040, ALLY-1, ALLY-2 and ALLY-3).
Croatian: Djelotvornost i sigurnost daklatazvira u dozi od 60 mg jedanput na dan u kombinaciji sa sofosbuvirom u dozi od 400 mg jedanput na dan u liječenju bolesnika s kroničnom infekcijom HCV-om bile su ocijenjene u četiri otvorena ispitivanja (AI444040, ALLY-1, ALLY-2 i ALLY-3).
English: Caution should be used when Daklinza is coadministered with rosuvastatin or other substrates of OATP 1B1 or BCRP.
Croatian: Potreban je oprez kada se Daklinza primjenjuje istodobno s rosuvastatinom ili drugim supstratima za OATP 1B1 ili BCRP.
English: For detailed recommendations regarding pregnancy and contraception, refer to the Summary of Product Characteristics for ribavirin and peginterferon alfa.
Croatian: Za detaljne preporuke o trudnoći i kontracepciji, pročitajte Sažetke opisa svojstava lijeka za ribavirin i peginterferon alfa.
English: <75 kg or ≥75 kg, respectively).
Croatian: (prijelomna vrijednost: 75 kg).
English: L31V and Y93H were frequently observed resistance substitutions in genotype 1b, while M28T, L31V/M, Q30E/H/R, and Y93C/H/N were frequently observed resistance substitutions in genotype 1a.
Croatian: L31V i Y93H bile su često primijećene supstitucije koje uzrokuju rezistenciju genotipa 1b, dok su M28T, L31V/M, Q30E/H/R i Y93C/H/N bile često primijećene supstitucije koje uzrokuju rezistenciju genotipa 1a.
English: Table 8: Demographics and main disease characteristics in Study ALLY-1 Cirrhotic cohort N = 60
Croatian: Tablica 8: Demografske značajke bolesnika i glavne značajke bolesti u ispitivanju ALLY-1 Kohorta s cirozom N = 60
English: Table 4: Interactions and dose recommendations with other medicinal products Medicinal products by therapeutic areas
Croatian: Tablica 4: Interakcije i preporuke za doziranje kod primjene s drugim lijekovima Lijekovi prema terapijskim područjima
English: If the starting dose is not well-tolerated, the dose should be reduced as clinically indicated, based on haemoglobin and creatinine clearance measurements (see Table 2).
Croatian: Ako bolesnik ne podnosi dobro početnu dozu, treba je smanjiti sukladno kliničkoj potrebi, na temelju izmjerenih vrijednosti hemoglobina i klirensa kreatinina (vidjeti
English: Warnings and precautions Talk to your doctor or pharmacist before taking Daklinza.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete lijek Daklinza.
English: For HCV genotype specific activity, see sections 4.4 and 5.1.
Croatian: Za aktivnost protiv pojedinog HCV genotipa vidjeti dijelove 4.4 i 5.1.
English: SVR12 rates were higher for patients with the IL-28B CC genotype than for those with non-CC genotypes and for patients with baseline HCV RNA less than 800,000 IU/ml but consistently higher in the daclatasvir-treated patients than for placebo-treated patients in all subgroups.
Croatian: Stope SVR12 bile su više u bolesnika koji su imali CC genotip za IL-28B nego u onih koji nisu imali CC genotip te u bolesnika u kojih je početna razina HCV RNK bila manja od 800 000 IU/ml, ali su u svim podskupinama bile dosljedno više u bolesnika liječenih daklatazvirom nego u onih koji su primali placebo.
English: Patients who had missing data at follow-up Week 12 were considered responders if their next available HCV RNA value was <LLOQ.
Croatian: Za bolesnike za koje su nedostajali podaci u 12. tjednu praćenja smatralo se da su odgovorili na liječenje ako im je sljedeća dostupna razina HCV RNK bila <LLOQ.
English: An oral contraceptive containing ethinylestradiol 35 μg and norgestimate
Croatian: Preporučuje se primjena oralnog kontraceptiva koji sadrži 35 μg etinilestradiola i
English: Metabolism and nutrition disorders common decreased appetite
Croatian: Poremećaji metabolizma i prehrane često smanjen tek
English: In clinical studies of daclatasvir in combination with sofosbuvir or with peginterferon alfa and ribavirin, plasma HCV RNA values were measured using the COBAS TaqMan HCV test (version 2.0), for use with the High Pure System, with a lower limit of quantification (LLOQ) of 25 IU/ ml.
Croatian: U kliničkim ispitivanjima daklatazvira u kombinaciji sa sofosbuvirom ili peginterferonom alfa i ribavirinom, vrijednosti HCV RNK u plazmi mjerene su COBAS TaqMan HCV testom (verzija 2.0), namijenjenim za uporabu sa sustavom High Pure System, uz donju granicu kvantifikacije (engl. lower limit of quantification, LLOQ) od 25 IU/ml.
English: Daclatasvir is an inhibitor of P-gp, organic anion transporting polypeptide (OATP) 1B1, OCT1 and breast cancer resistance protein (BCRP).
Croatian: Daklatazvir je inhibitor P-gp-a, organskog anionskog transportnog polipeptida (OATP) 1B1, OCT1 te proteina rezistencije na rak dojke (BCRP).