FrancophonIA/ELRC3.0 huggingface dataset:
English: Symptoms suggestive of hypersensitivity (* marked in the table above) have been noted, overall in approximately 3% of the patients.
Croatian: Simptomi koji upućuju na preosjetljivost (označeni * u prethodnoj tablici) zabilježeni su sveukupno u približno 3% bolesnika.
English: Occasionally, small dosage adjustments may be made to avoid discarding partially used vials.
Croatian: Povremeno može biti potrebno malo prilagoditi dozu da bi se spriječilo bacanje djelomično upotrijebljenih bočica.
English: If you have missed an infusion, please contact your doctor.
Croatian: Ako ste propustili infuziju, molimo obratite se liječniku.
English: After reconstitution and dilution, the preparation is administered by intravenous infusion.
Croatian: Nakon rekonstitucije i razrjeđivanja, pripravak se primjenjuje intravenskom infuzijom.
English: Patients with antibody to imiglucerase have a higher risk of hypersensitivity reactions (see section 4.8).
Croatian: U bolesnika s protutijelima na imiglucerazu postoji veći rizik od reakcija preosjetljivosti (vidjeti dio 4.8).
English: These symptoms generally respond to treatment with antihistamines and/or corticosteroids.
Croatian: Navedeni simptomi u pravilu reagiraju na liječenje antihistaminicima i/ili kortikosteroidima.
English: - if you are allergic to imiglucerase or any of the other ingredients of this medicine (listed in section 6).
Croatian: - ako ste alergični na imiglucerazu ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: The natural history of Gaucher disease usually shows progression, with the risk of irreversible complications arising in various organs over time.
Croatian: Prirodni tijek Gaucherove bolesti obično pokazuje progresiju, uz rizik nastanka trajnih komplikacija u različitim organima tijekom vremena.
English: Once individual patient response for all relevant clinical manifestations is wellestablished, dosages and frequency of administration may be adjusted with the goal to either maintain already reached optimal parameters for all clinical manifestations or further improve those clinical parameters which have not yet been normalised.
Croatian: Jednom kada se u pojedinog bolesnika uspostavi dobar terapijski odgovor za sve značajne kliničke manifestacije bolesti, doziranje i učestalost primjene mogu se prilagođavati s ciljem održavanja već postignutih optimalnih parametara za sve kliničke manifestacije ili dodatnog poboljšanja onih kliničkih parametara koji se još nisu u potpunosti normalizirali.
English: No animal studies have been carried out with respect to assessing the effects of Cerezyme on pregnancy, embryonal/foetal development, parturition and postnatal development.
Croatian: Nisu provedena ispitivanja na životinjama kojima bi se procijenio učinak lijeka Cerezyme na trudnoću, razvoj embrija/ploda, porođaj i postnatalni razvoj.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu/.
Croatian: Detaljne informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu/.
English: From a microbiological safety point of view, the product should be used immediately.
Croatian: S mikrobiološkog stajališta lijek se mora odmah primijeniti.
English: The patient or caregiver will be instructed in infusion technique and the keeping of a treatment diary.
Croatian: Bolesnik ili njegovatelj bit će upućeni u tehniku primjene infuzije i vođenje dnevnika liječenja.
English: It can occur whether the patient is treated with Cerezyme or not.
Croatian: Može se pojaviti bez obzira na to liječi li se bolesnik lijekom Cerezyme ili ne.
English: Signs and symptoms presenting in childhood typically represent more severe Gaucher disease.
Croatian: Znakovi i simptomi koji se pojavljuju u djetinjstvu obično predstavljaju teži oblik Gaucherove bolesti.
English: Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk CB9 8PU, United Kingdom Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Ireland
Croatian: Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk CB9 8PU, Ujedinjeno Kraljevstvo Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Irska
English: It is not known whether Cerezyme passes via the placenta to the developing foetus.
Croatian: Nije poznato prolazi li Cerezyme kroz placentu do ploda u razvoju.
English: Your dose will be specific to you.
Croatian: Doza lijeka bit će primjerena Vama.
English: - The active substance is imiglucerase.
Croatian: - Djelatna tvar je imigluceraza.
English: Dosages may be rounded to the nearest full vial, as long as the monthly administered dosage remains substantially unaltered.
Croatian: Doziranje se može zaokružiti na količinu najbližu punoj bočici ako se ukupna primijenjena mjesečna doza pritom bitno ne mijenja.
English: What Cerezyme looks like and contents of the pack
Croatian: Kako Cerezyme izgleda i sadržaj pakiranja
English: If not used immediately, in-use storage and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C - 8°C under protection from light.
Croatian: Ako se ne primijeni odmah, vrijeme i uvjeti čuvanja lijeka prije primjene odgovornost su korisnika i ne smiju premašiti 24 sata na temperaturi od 2°C do 8°C, zaštićeno od svjetlosti.
English: What Cerezyme is and what it is used for
Croatian: Što je Cerezyme i za što se koristi
English: Genzyme Europe B.V., Paasheuvelweg 25, 1105 BP, Amsterdam, the Netherlands
Croatian: Genzyme Europe B.V., Paasheuvelweg 25, 1105 BP Amsterdam, Nizozemska
English: Cerezyme contains no preservatives.
Croatian: Cerezyme ne sadrži konzervanse.
English: * An enzyme unit (U) is defined as the amount of enzyme that catalyses the hydrolysis of one micromole of the synthetic substrate para-nitrophenyl β-D-glucopyranoside (pNP-Glc) per minute at 37°C.
Croatian: * Enzimska jedinica (U) definirana je kao količina enzima koja katalizira hidrolizu jednog mikromola sintetičkog supstrata paranitrofenil β-D-glukopiranozida (pNP-Glc) u minuti na temperaturi od 37°C.
English: As with any intravenous protein product, severe allergic-type hypersensitivity reactions are possible, but occur uncommonly.
Croatian: Kao i kod drugih intravenskih proteinskih lijekova, moguće su teške alergijske reakcije preosjetljivosti, ali se one javljaju manje često.
English: Limited experience from 150 pregnancy outcomes (primarily based on spontaneous reporting and literature review) is available suggesting that use of Cerezyme is beneficial to control the underlying Gaucher disease in pregnancy.
Croatian: Postoji ograničeno iskustvo o ishodima 150 trudnoća (prvenstveno temeljeno na spontanom prijavljivanju i podacima iz literature) koje upućuje na to da primjena lijeka Cerezyme ima pozitivan učinak na kontrolu ranije dijagnosticirane Gaucherove bolesti tijekom trudnoće.
English: Contents of the pack and other information What Cerezyme contains
Croatian: Sadržaj pakiranja i druge informacije Što Cerezyme sadrži
English: Clinically, Gaucher disease is a heterogeneous phenotypic spectrum.
Croatian: Klinički, Gaucherova bolest ima heterogeni fenotipski spektar.
English: Store in a refrigerator (2°C - 8°C).
Croatian: Čuvati u hladnjaku (2°C - 8°C)
English: It is recommended that the diluted solution be administered within 3 hours.
Croatian: Razrijeđenu otopinu preporučuje se primijeniti unutar 3 sata.
English: Furthermore, these data indicate no malformative toxicity for the foetus by Cerezyme, although the statistical evidence is low.
Croatian: Nadalje, ovi podaci ne upućuju na malformacijsku toksičnost lijeka Cerezyme na plod , iako su statistički dokazi koji to potvrđuju malobrojni.
English: Generally, improvements in organ systems with a faster turnover rate, such as the haematological, can be noted far more rapidly than in those with a slower turnover, such as the bone.
Croatian: Općenito se poboljšanja u organskim sustavima u kojima se stanice brže obnavljaju, poput hematološkog sustava, može primijetiti mnogo prije nego u sustavima u kojima se stanice obnavljaju sporije, poput koštanog sustava.
English: If you experience any of these symptoms, please tell your doctor immediately.
Croatian: Ako Vam se pojavi bilo koji od ovih simptoma, molimo odmah o tome obavijestite svog liječnika.
English: Pulmonary hypertension is a known complication of Gaucher disease.
Croatian: Plućna hipertenzija je poznata komplikacija Gaucherove bolesti.
English: In Gaucher disease glucosylceramide levels can get too high.
Croatian: Kod Gaucherove bolesti vrijednosti glukozilceramida mogu postati previsoke.
English: At subsequent administrations, infusion rate may be increased but should not exceed 1 unit per kg body weight per minute.
Croatian: Tijekom kasnijih primjena, brzina infuzije može se povećati, ali ne smije premašiti 1 jedinicu po kilogramu tjelesne težine u minuti.
English: Gaucher disease is associated with increased morbidity and early mortality.
Croatian: Gaucherova bolest povezana je s povećanim pobolom i ranom smrtnošću.
English: Instructions for proper use Cerezyme is given through a drip into a vein (by intravenous infusion).
Croatian: Upute za ispravnu primjenu Cerezyme se primjenjuje kapanjem (dripom) u venu (intravenskom infuzijom).
English: The current medical standards for emergency treatment are to be observed.
Croatian: Za hitno liječenje, treba slijediti postojeće medicinske standarde.
English: A Q4 infusion regimen may be a therapeutic option for some adult patients with stable residual Gaucher disease type 1, but clinical data are limited.
Croatian: Režim primjene infuzije svaka 4 tjedna mogao bi predstavljati terapijsku opciju za neke odrasle bolesnike sa stabilnom rezidualnom Gaucherovom bolešću tipa 1, no klinički podaci su ograničeni.
English: Some side effects were seen primarily while patients were being given the medicine or shortly after.
Croatian: Neke su se nuspojave pojavile prvenstveno tijekom primjene lijeka bolesnicima ili neposredno nakon toga.
English: Foetal demise has been reported rarely, although it is not clear whether this related to the use of Cerezyme or to the underlying Gaucher disease.
Croatian: Rijetko je prijavljena smrt ploda, ali nije jasno je li ona povezana s primjenom lijeka Cerezyme ili s osnovnom Gaucherovom bolešću.
English: Urticaria/angioedema*, pruritus*, rash*
Croatian: Urtikarija/angioedem*, pruritus*, osip*
English: It is recommended that Cerezyme is used immediately after it has been mixed with sterile water.
Croatian: Preporučuje se primijeniti lijek Cerezyme odmah nakon miješanja sa sterilnom vodom.
English: The rate and extent of response to Cerezyme treatment is dose-dependent.
Croatian: Brzina i opseg odgovora na liječenje lijekom Cerezyme ovisi o dozi.
English: During 1 hour intravenous infusions of 4 doses (7.5, 15, 30, 60 U/kg) of imiglucerase, steady-state enzymatic activity was achieved by 30 minutes.
Croatian: Pri jednosatnim intravenskim infuzijama 4 doze (7,5, 15, 30, 60 U/kg) imigluceraze stanje dinamičke ravnoteže enzimske aktivnosti postignuto je nakon 30 minuta.
English: Cerezyme therapy reduces the requirement for splenectomy in most cases and early treatment with Cerezyme has been associated with a reduced risk of pulmonary hypertension.
Croatian: Liječenje lijekom Cerezyme u većini slučajeva smanjuje potrebu za splenektomijom, a rano liječenje lijekom Cerezyme povezuje se sa smanjenim rizikom od razvoja plućne hipertenzije.
English: Patients who have developed antibodies or symptoms of hypersensitivity to Ceredase (alglucerase) should be treated with caution when administering Cerezyme (imiglucerase).
Croatian: U bolesnika koji su razvili protutijela ili simptome preosjetljivosti na Ceredase (alglucerazu), Cerezyme (imigluceraza) se mora primjenjivati uz oprez.
English: Therefore no conclusions on the effect of enzyme replacement therapy on the neurological manifestations of the disease can be drawn.
Croatian: Stoga se ne mogu donijeti zaključci o učinku enzimske nadomjesne terapije na neurološke manifestacije bolesti.
English: Instructions for use - reconstitution, dilution and administration Each vial of Cerezyme is for single use only.
Croatian: Upute za uporabu - rekonstitucija, razrjeđivanje i primjena Jedna bočica lijeka Cerezyme namijenjena je isključivo za jednokratnu uporabu.
English: Close monitoring of the pregnancy and clinical manifestations of Gaucher disease is necessary for the individualization of dose according to the patient's needs and therapeutic response.
Croatian: Nužno je pažljivo praćenje trudnoće i kliničkih manifestacija Gaucherove bolesti radi određivanja individualnih doza lijeka u skladu s potrebama i terapijskim odgovorom bolesnice.
English: If you forget to use Cerezyme
Croatian: Ako ste zaboravili primijeniti lijek Cerezyme
English: It appears that patients who will develop IgG antibody are most likely to do so within 6 months of treatment and will rarely develop antibodies to Cerezyme after 12 months of therapy.
Croatian: Čini se da bolesnici najčešće stvaraju IgG protutijela tijekom prvih 6 mjeseci liječenja, a rijetko stvaraju protutijela na Cerezyme nakon 12 mjeseci liječenja.
English: Dose and infusion rate should remain constant while at home, and not be changed without supervision of a health care professional.
Croatian: Kad se infuzija primjenjuje kod kuće, doza i brzina moraju biti konstantne i ne smiju se mijenjati bez nadzora zdravstvenog djelatnika.
English: Talk to your doctor or pharmacist before using Cerezyme: - if you are treated with Cerezyme, you may experience an allergic reaction while you are being given the medicine or shortly after.
Croatian: Obratite se svome liječniku ili ljekarniku prije nego primite Cerezyme: - ako se liječite lijekom Cerezyme, možete doživjeti alergijsku reakciju tijekom primjene lijeka ili neposredno nakon toga.
English: Rare (may affect up to 1 in 1,000 people): - anaphylactoid reactions
Croatian: Rijetko (mogu se javiti u manje od 1 na 1000 osoba): - anafilaktoidne reakcije
English: Cerezyme has been shown to improve both mental and physical aspects in the quality of life of Gaucher disease.
Croatian: Pokazalo se da Cerezyme poboljšava mentalne i fizičke aspekte kvalitete života bolesnika s Gaucherovom bolešću.
English: Pharmacotherapeutic group: Enzymes-Imiglucerase (recombinant macrophage targeted βglucocerebrosidase), ATC code: A16AB02.
Croatian: Farmakoterapijska skupina: Enzimi - imigluceraza (rekombinantna β-glukocerebrozidaza koja ciljano djeluje na makrofage), ATK oznaka: A16AB02.
English: Plasma clearance ranged from 9.8 to 20.3 ml/min/kg, (mean ± S.D, 14.5 ± 4.0 ml/min/kg).
Croatian: Klirens iz plazme se kretao u rasponu od 9,8 do 20,3 ml/min/kg, (srednja vrijednost ± SD, 14,5 ± 4,0 ml/min/kg).
English: The volume of distribution corrected for weight ranged from 0.09 to 0.15 l/kg (mean ± S.D 0.12 ± 0.02 l/kg).
Croatian: Volumen distribucije korigiran za tjelesnu težinu bio je u rasponu od 0,09 do 0,15 l/kg (srednja vrijednost ± SD 0,12 ± 0,02 l/kg).
English: This enzyme helps the body control levels of glucosylceramide.
Croatian: Taj enzim pomaže tijelu u kontroli razine glukozilceramida.
English: The clinical manifestations of Gaucher disease can adversely affect quality of life.
Croatian: Gaucherove bolesti mogu loše utjecati na kvalitetu života.
English: Patients experiencing adverse events during the infusion need to immediately stop the infusion process and seek the attention of a healthcare professional.
Croatian: Bolesnici u kojih tijekom primanja infuzije nastupe nuspojave, moraju odmah prekinuti infuziju i potražiti pomoć zdravstvenog djelatnika.
English: You can ask your doctor to register your patient information into the “ICGG Gaucher Registry”.
Croatian: Možete zamoliti svoga liječnika da Vaše bolesničke podatke prijavi u “ICGG registar bolesnika s
English: Due to the heterogeneity and the multi-systemic nature of Gaucher disease, dosage should be individualised for each patient based on a comprehensive evaluation of all clinical manifestations of the disease.
Croatian: Doziranje Zbog heterogenosti i multisistemske prirode Gaucherove bolesti, doziranje se mora prilagoditi svakom pojedinom bolesniku na temelju sveobuhvatne procjene svih kliničkih manifestacija bolesti.
English: There are no cases of overdose of Cerezyme reported.
Croatian: Nema prijavljenih slučajeva predoziranja lijekom Cerezyme.
English: It is not known whether this active substance is excreted in human milk, however, the enzyme is likely to be digested in the child's gastrointestinal tract
Croatian: Nije poznato izlučuje li se ova djelatna tvar u majčino mlijeko, ali se enzim vjerojatno probavlja u probavnom sustavu djeteta.
English: Glucosylceramide is a natural substance in the body, made of sugar and fat.
Croatian: Glukozilceramid je prirodna tvar u ljudskome tijelu, a sačinjavaju je šećer i masnoća.
English: Your doctor may test if you have an allergic reaction to imiglucerase.
Croatian: Liječnik Vas može poslati na pretrage kako bi ispitao imate li alergijsku reakciju na imiglucerazu.
English: - some patients with Gaucher disease have high blood pressure in the lungs (pulmonary hypertension).
Croatian: - neki bolesnici s Gaucherovom bolešću imaju visok krvni tlak u plućima (plućnu hipertenziju).
English: In addition, Gaucher disease has been associated with an increased risk of immunoglobulin abnormalities such as hyperimmunoglobulinemia, polyclonal gammopathy, monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma.
Croatian: Nadalje, Gaucherova je bolest povezana s povećanim rizikom od poremećaja imunoglobulina, poput hiperimunoglobulinemije, poliklonske gamopatije, monoklonske gamopatije neodređenog značaja (engl. monoclonal gammopathy of undetermined significance,
English: In children, Cerezyme has been shown to enable normal pubertal development, and to induce catch-up growth, leading to normal height and bone mineral density in adulthood.
Croatian: Pokazalo se da Cerezyme u djece omogućava normalan razvoj u pubertetu te nadoknađuje zastoj u rastu, što omogućuje postizanje normalne visine i mineralne gustoće kostiju u odrasloj dobi.
English: Patients who have Gaucher disease and become pregnant may experience a period of increased disease activity during pregnancy and the puerperium.
Croatian: Bolesnice s Gaucherovom bolešću koje zatrudne mogu proći kroz razdoblje pojačane aktivnosti bolesti tijekom trudnoće i puerperija.
English: Cerezyme is an artificial enzyme called imiglucerase - this can replace the natural enzyme acid β-glucosidase which is lacking or not active enough in patients with Gaucher disease.
Croatian: Cerezyme je umjetni enzim koji se naziva imigluceraza - on može nadomjestiti prirodni enzim kiselu β-glukozidazu koja nedostaje ili nije dovoljno aktivna u bolesnika s Gaucherovom bolešću.
English: Cerezyme (imiglucerase) is indicated for use as long-term enzyme replacement therapy in patients with a confirmed diagnosis of non-neuronopathic (Type 1) or chronic neuronopathic (Type 3) Gaucher disease who exhibit clinically significant non-neurological manifestations of the disease.
Croatian: Cerezyme (imigluceraza) je indiciran kao dugotrajna enzimska nadomjesna terapija u bolesnika s potvrđenom dijagnozom neneuropatske (tip 1) ili kronične neuropatske (tip 3) Gaucherove bolesti koji pokazuju klinički značajne manifestacije bolesti koje nisu neurološke naravi.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS LABEL / VIAL
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE NALJEPNICA / BOČICA
English: Cerezyme reduces spleen and liver size, improves or normalises thrombocytopenia and anaemia, improves or normalises bone mineral density and bone marrow burden, and reduces or eliminates bone pain and bone crises.
Croatian: Cerezyme smanjuje veličinu slezene i jetre, poboljšava ili normalizira trombocitopeniju i anemiju, poboljšava ili normalizira mineralnu gustoću kostiju i opterećenje koštane srži te smanjuje ili uklanja bol u kostima i koštane krize.
English: Patients treated with 60 U/kg body weight every 2 weeks showed a faster improvement and a greater maximum treatment effect as compared to patients receiving the lower doses.
Croatian: U bolesnika liječenih dozom od 60 U/kg tjelesne težine jedanput svaka 2 tjedna zabilježeno je brže poboljšanje i veći maksimalni učinak liječenja u usporedbi s bolesnicima koji su primali niže doze.
English: In women receiving Cerezyme treatment continuation throughout pregnancy should be considered.
Croatian: U žena koje se liječe lijekom Cerezyme treba razmotriti nastavak liječenja tijekom trudnoće.
English: Gaucher cells are typically found in liver, spleen and bone marrow and occasionally in lung, kidney and intestine.
Croatian: Gaucherove stanice se obično nalaze u jetri, slezeni i koštanoj srži, a ponekad i u plućima, bubrezima i crijevima.
English: If a patient experiences a reaction suggestive of hypersensitivity, subsequent testing for imiglucerase antibodies is advised.
Croatian: Ako se u bolesnika pojavi reakcija koja upućuje na preosjetljivost, preporučuje se testiranje na protutijela na imiglucerazu.
English: If you experience a reaction like this, you should tell your doctor immediately.
Croatian: Ako dođe do takve reakcije, odmah o tome obavijestite svog liječnika.
English: Then dilute the combined volumes with 0.9% sodium chloride intravenous solution to a total volume of 100 to 200 ml.
Croatian: Zatim tako dobiveni volumen otopine razrijedite s 0,9%-tnom otopinom natrijevog klorida za intravensku primjenu do ukupnog volumena od 100 do 200 ml.
English: This enzyme breaks down glucosylceramide, a key component of the lipid structure of cell membranes, into glucose and ceramide.
Croatian: Ovaj enzim razgrađuje glukozilceramid, ključnu komponentu u lipidnoj strukturi stanične membrane, u glukozu i ceramid.
English: If these reactions occur, immediate discontinuation of the Cerezyme infusion is recommended and appropriate medical treatment should be initiated.
Croatian: preporučuje se odmah prekinuti infuziju lijeka Cerezyme i započeti odgovarajuće liječenje.
English: In children, Gaucher disease can lead to growth retardation and delayed puberty.
Croatian: U djece Gaucherova bolest može dovesti do zastoja u rastu i zakašnjelog puberteta.
English: Patients who have undergone a splenectomy have an increased risk of pulmonary hypertension.
Croatian: U bolesnika koji su bili podvrgnuti splenektomiji postoji povećan rizik od razvoja plućne hipertenzije.
English: No controlled clinical studies have been conducted on the efficacy of Cerezyme on neurological manifestations of the disease.
Croatian: Nisu provedena kontrolirana klinička ispitivanja djelotvornosti lijeka Cerezyme na neurološke manifestacije bolesti.
English: Current data using a screening ELISA followed by a confirmatory radioimmunoprecipitation assay, suggest that, during the first year of therapy, IgG antibodies to imiglucerase are formed in approximately 15% of the treated patients.
Croatian: Preosjetljivost Postojeći podaci dobiveni probirom ELISA testom i potvrđeni radioimunoprecipitacijskim testom upućuju na to da se tijekom prve godine liječenja u približno 15% liječenih bolesnika stvaraju
English: Name and address of the manufacturer of the biological active substance Genzyme Corporation, 500 Soldiers Field Road, Allston, MA 02134, USA Lonza Biologics Inc., 101 International Drive, Portsmouth, NH 03801-2815, USA Name and address of the manufacturers responsible for batch release Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk CB9 8PU, United Kingdom Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Ireland The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Croatian: Genzyme Corporation, 500 Soldiers Field Road, Allston, MA 02134, SAD Lonza Biologics Inc., 101 International Drive, Portsmouth, NH 03801-2815, SAD Naziv i adresa proizvođača odgovornih za puštanje serije lijeka u promet Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk CB9 8PU, Ujedinjeno Kraljevstvo Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Irska