FrancophonIA/ELRC3.0 huggingface dataset:
English: Aliskiren is a substance that belongs to a group of medicines called renin inhibitors.
Slovenian: Aliskiren je snov, ki sodi v skupino zdravil z imenom zaviralci renina.
English: - Medicinal products that could induce torsades de pointes Due to the risk of hypokalaemia, hydrochlorothiazide should be administered with caution when associated with medicinal products that could induce torsades de pointes, in particular Class Ia and Class III antiarrhythmics and some antipsychotics.
Slovenian: - Zdravila, ki lahko sprožijo torsades de pointes Zaradi nevarnosti hipokaliemije je potrebna previdnost pri uporabi hidroklorotiazida v kombinaciji z zdravili, ki lahko sprožijo torsades de pointes, zlasti z antiaritmiki skupin Ia in III in z nekaterimi antipsihotiki.
English: In children 6 to 12 years and in adolescents 13-17 years of age the typical oral clearance (CL/F) was 22.5 and 27.4 l/hr respectively in males and 16.4 and 21.3 l/hr respectively in females.
Slovenian: Pri otrocih, starih od 6 do 12 let in mladostnikih, starih od 13 do 17 let, je bil tipičen peroralni očistek (CL/F) 22,5 oziroma 27,4 l/uro pri fantih in 16,4 oziroma 21,3 l/uro pri puncah.
English: Following intravenous administration, mean plasma clearance is approximately 9 l/h.
Slovenian: Po intravenski aplikaciji je povprečni plazemski očistek približno 9 l/h.
English: What Rasitrio is and what it is used for
Slovenian: Kaj je zdravilo Rasitrio in za kaj ga uporabljamo
English: The concomitant use of CYP3A4 inducers (e.g. rifampicin, hypericum perforatum) may give a lower plasma concentration of amlodipine.
Slovenian: Sočasna uporaba induktorjev CYP3A4 (kot sta rifampicin, Hypericum perforatum) lahko zniža koncentracijo amlodipina v plazmi.
English: A population pharmacokinetic study has been conducted in 74 hypertensive children aged from 1 to 17 years (with 34 patients aged 6 to 12 years and 28 patients aged 13 to 17 years) receiving amlodipine between 1.25 and 20 mg given either once or twice daily.
Slovenian: Farmakokinetično populacijsko študijo so izvedli pri 74 hipertenzivnih otrocih, starih od 1 do 17 let (34 bolnikov je bilo starih od 6 do 12 let in 28 bolnikov starih od 13 do 17 let), ki so prejemali med 1.25 in 20 mg amlodipina enkrat oziroma dvakrat dnevno.
English: Do not take Rasitrio - if you are allergic to aliskiren, to amlodipine, to other dihydropyridine-derived medicines (known as calcium channel blockers), to hydrochlorothiazide, to sulphonamide-derived medicines (medicines used to treat chest or urinary infections) or to any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Rasitrio - če ste alergični na aliskiren, na amlodipin, na druge dihidropiridinske derivate (ki so znani kot zaviralci kalcijevih kanalčkov), na hidroklorotiazid, na sulfonamidna zdravila (zdravila za zdravljenje okužb prsnega koša ali sečil) ali na katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle, causing reductions in peripheral vascular resistance and in blood pressure.
Slovenian: Mehanizem antihipertenzivnega delovanja amlodipina je posledica neposrednega relaksacijskega učinka na žilne gladke mišice, s čemer zmanjša periferni žilni upor in krvni tlak.
English: As with any antihypertensive medicinal product, excessive reduction of blood pressure in patients with ischaemic cardiopathy or ischaemic cardiovascular disease could result in a myocardial infarction or stroke.
Slovenian: Tako kot pri uporabi kateregakoli antihipertenzivnega zdravila, lahko prekomerno znižanje krvnega tlaka pri bolnikih z ishemično boleznijo srca ali ishemično kardiovaskularno boleznijo povzroči miokardni infarkt ali možgansko kap.
English: In the majority of patients aged 65 years or older, the 300 mg dose of aliskiren shows no additional benefit in reducing blood pressure compared to the 150 mg dose.
Slovenian: Pri večini bolnikov, starih 65 let ali več, 300 mg odmerek aliskirena ni pokazal nobenih dodatnih koristi v zniževanju krvnega tlaka v primerjavi s 150 mg odmerkom.
English: As with other calcium channel blockers, haemodynamic measurements of cardiac function at rest and during exercise (or pacing) in patients with normal ventricular function treated with amlodipine have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volume.
Slovenian: Tako kot pri drugih zaviralcih kalcijevih kanalčkov so hemodinamske meritve delovanja srca v mirovanju in med obremenitvijo (ali stimulacijo s spodbujevalnikom) pri bolnikih z normalnim delovanjem prekatov, ki so dobivali amlodipin, na splošno pokazale majhno povečanje srčnega indeksa, a brez pomembnega vpliva na dP/dt ali končni diastolični tlak ali volumen levega prekata.
English: • liver disorders which can occur together with yellow skin and eyes
Slovenian: • bolezni jeter, ki jih lahko spremljajo rumena koža in oči
English: Amlodipine has demonstrated beneficial clinical effects in patients with chronic stable angina, vasospastic angina and angiographically documented coronary artery disease.
Slovenian: Amlodipin je klinično ugodno vplival na bolnike s kronično stabilno angino pektoris, z vazospastično angino pektoris in z angiografsko potrjeno koronarno boleznijo.
English: Aliskiren is metabolised minimally by the cytochrome P450 enzymes.
Slovenian: Aliskiren se v zelo majhni meri presnavlja z encimi citokroma P450.
English: What Rasitrio is and what it is used for What you need to know before you take Rasitrio How to take Rasitrio
Slovenian: Kaj je zdravilo Rasitrio in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Rasitrio Kako jemati zdravilo Rasitrio Možni neželeni učinki
English: Posology The recommended dose of Rasitrio is one tablet per day.
Slovenian: Odmerjanje Priporočeni odmerek zdravila Rasitrio je ena tableta na dan.
English: You should not take this medicine together with grapefruit juice.
Slovenian: Tega zdravila ne smete jemati skupaj z grenivkinim sokom.
English: Therefore the use of Rasitrio with an NSAID requires caution, especially in elderly patients.
Slovenian: Zato je pri uporabi zdravila Rasitrio z nesteroidnimi protivnetnimi zdravili, posebno pri starejših bolnikih, potrebna previdnost.
English: Effects of amlodipine on other medicinal products - The blood pressure lowering effects of amlodipine add to the blood pressure lowering effects of other antihypertensive medicinal products.
Slovenian: Vpliv amlodipina na druga zdravila - Zniževanje krvnega tlaka, ki ga povzroča amlodipin, se sešteva z zniževanjem krvnega tlaka, ki ga povzročajo druga antihipertenzivna zdravila.
English: Risk factors for developing acute angle-closure glaucoma may include a history of sulphonamide or penicillin allergy.
Slovenian: Med dejavniki tveganja za razvoj akutnega glavkoma zaprtega zakotja je lahko anamneza alergije na sulfonamide ali penicilin.
English: Hydrochlorothiazide belongs to a group of medicines called thiazide diuretics.
Slovenian: Hidroklorotiazid sodi v skupino zdravil z imenom tiazidni diuretiki.
English: The amlodipine component of Rasitrio inhibits the transmembrane entry of calcium ions into cardiac and vascular smooth muscle.
Slovenian: Amlodipin v zdravilu Rasitrio zavira transmembranski vstop kalcijevih ionov v srčne in žilne gladke mišice.
English: In the event of any signs suggesting a hypersensitivity reaction/angioedema (in particular difficulties in breathing, or swallowing, rash, itching, hives or swelling of the face, extremities, eyes, lips and/or tongue, dizziness) patients should discontinue treatment and contact the physician (see section 4.4).
Slovenian: V primeru znakov, ki bi nakazovali preobčutljivostno reakcijo/angioedem (še posebno, če gre za težave z dihanjem ali pri požiranju, izpuščaj, srbenje, koprivnico ali otekanje obraza, okončin, oči, ustnic in/ali jezika, omotico), mora bolnik prekiniti zdravljenje in se obrniti na zdravnika (glejte poglavje 4.4).
English: PVC/polychlorotrifluoroethylene (PCTFE) - Alu calendar blisters: Single pack containing 14, 28, 56, 98 tablets
Slovenian: PVC/poliklorotrifluoroetilen (PCTFE) - Alu koledarski pretisni omoti: Posamično pakiranje vsebuje 14, 28, 56 ali 98 tablet.
English: In particular there was an increased incidence of renal dysfunction (14.0% versus 12.1%), hyperkalaemia (38.9% versus 28.8%), hypotension-related events (19.7% versus 16.2%) and adjudicated stroke endpoints (3.4% versus 2.6%).
Slovenian: Do povečane pogostnosti je prišlo zlasti pri ledvični disfunkciji (14,0 % v primerjavi z 12,1 %), hiperkaliemiji (38,9 % v primerjavi z 28,8 %), dogodkih v povezavi s hipotenzijo (19,7 % v primerjavi s 16,2 %) in pri izidih domnevne možganske kapi (3,4 % v primerjavi z 2,6 %).
English: - Grapefruit juice
Slovenian: - Grenivkin sok
English: Following oral absorption, peak plasma concentrations of aliskiren are reached after 1-3 hours.
Slovenian: Po peroralni absorpciji doseže aliskiren največje koncentracije v plazmi po 1-3 urah.
English: The mean weight of patients concomitantly treated with furosemide and 300 mg aliskiren (84.6 kg) was higher than the weight of patients treated with furosemide alone (83.4 kg).
Slovenian: Pri bolnikih, ki so sočasno prejemali furosemid in aliskiren v odmerku 300 mg, je bila povprečna telesna masa (84,6 kg) večja kot pri bolnikih, ki so prejemali samo furosemid (83,4 kg).
English: If any of the above applies to you, do not take Rasitrio and talk to your doctor.
Slovenian: Če karkoli od navedenega velja za vas, ne začnite jemati zdravila Rasitrio, ampak se posvetujte z zdravnikom.
English: The safety and efficacy of Rasitrio in children and adolescents below age 18 have not been established.
Slovenian: Varnost in učinkovitost zdravila Rasitrio pri otrocih in mladostnikih, starih manj kot 18 let, nista bili dokazani.
English: The mode of action of thiazides is through inhibition of the Na+Cl- symporter by competing for the Cl- site, thereby affecting electrolyte reabsorption mechanisms: directly increasing sodium and chloride excretion to an approximately equal extent, and indirectly by this diuretic action reducing plasma volume, with consequent increases in plasma renin activity, aldosterone secretion and urinary potassium loss, and a decrease in serum potassium.
Slovenian: Tiazidi delujejo tako, da tekmujejo za vezavno mesto za Cl- ione na skupnem prenašalcu Na+ in Cl- ionov in ga na ta način zavirajo, s tem pa vplivajo na mehanizme reabsorpcije elektrolitov: neposredno povečajo izločanje natrija in klorida v približno enaki meri, posredno pa s takim diuretičnim delovanjem zmanjšajo volumen plazme, s tem povzročijo zvišanje aktivnosti renina v plazmi, izločanje aldosterona in izgubljanje kalija z urinom ter znižano koncentracijo kalija v serumu.
English: In a study conducted in patients with end stage renal disease (ESRD) receiving haemodialysis, dialysis clearance of aliskiren was low (<2% of oral clearance).
Slovenian: V študiji, ki so jo izvajali pri bolnikih s končno ledvično odpovedjo, ki so se zdravili s hemodializo, je bil dializni očistek aliskirena nizek (<2 % peroralnega očistka).
English: Efficacy of Rasitrio was maintained over one year of treatment, with no evidence of loss of effect.
Slovenian: Učinkovitost zdravila Rasitrio je v enem letu zdravljenja ostajala enaka, pri čemer niso opažali postopnega zmanjševanja učinka.
English: If patients taking amlodipine suffer from dizziness, drowsiness, headache, fatigue or nausea, the ability to react may be impaired.
Slovenian: Če so bolniki v času jemanja amlodipina omotični, zaspani, utrujeni, imajo glavobol ali navzeo, lahko to poslabša njihovo sposobnost odzivanja.
English: The clinical implications of the differences in effect on PRA are not known at the present time.
Slovenian: Klinični pomen drugačnega učinka na PRA zaenkrat ni znan.
English: As for any medicinal product that acts directly on the renin-angiotensin-aldosterone system, aliskiren should not be used during the first trimester of pregnancy and is contraindicated during the second and third trimesters (see section 4.3).
Slovenian: Tako kot velja za katerokoli drugo zdravilo, ki deluje neposredno na RAAS, se tudi aliskirena ne sme uporabljati v prvem trimesečju nosečnosti, kontraindiciran pa je tudi v drugem in tretjem trimesečju nosečnosti (glejte poglavje 4.3).
English: In a pharmacokinetic study of aliskiren treatment in 39 paediatric hypertensive patients (aged 6-17 years) given daily doses of 2 mg/kg or 6 mg/kg aliskiren administered as granules (3.125 mg/tablet), pharmacokinetic parameters were similar to those in adults.
Slovenian: V farmakokinetični študiji z aliskirenom pri zdravljenju 39 pediatričnih bolnikov s hipertenzijo (starih od 6 do 17 let), ki so prejemali dnevne odmerke aliskirena 2 mg/kg oziroma 6 mg/kg v obliki zrnc (3,125 mg/tableto), so bili farmakokinetični parametri podobni kot pri odraslih.
English: By inhibiting the enzyme renin, aliskiren inhibits the RAAS at the point of activation, blocking the conversion of angiotensinogen to angiotensin I and decreasing levels of angiotensin I and angiotensin II.
Slovenian: Z zaviranjem encima renina aliskiren zavre delovanje RAAS na točki aktivacije, saj zavre pretvorbo angiotenzinogena v angiotenzin I in tako zniža ravni angiotenzina I in angiotenzina II.
English: With amlodipine, available data suggest that gross overdose could result in excessive peripheral vasodilatation and possibly reflex tachycardia.
Slovenian: Po podatkih, ki so na voljo, bi izrazito visok odmerek amlodipina lahko povzročil čezmerno periferno vazodilatacijo in morda refleksno tahikardijo.
English: Reproductive studies in rats have shown no toxicity except for delayed date of delivery and prolonged duration of labour at dosages 50 times greater than the maximum recommended dosage for humans (see section 5.3).
Slovenian: V študijah vpliva na sposobnost razmnoževanja pri podganah niso opažali toksičnega delovanja razen zakasnitve in podaljšanja poroda pri odmerkih, ki so bili 50-krat višji od najvišjega priporočenega odmerka pri ljudeh (glejte poglavje 5.3).
English: Untreated acute angle-closure glaucoma can lead to permanent vision loss.
Slovenian: Nezdravljen akutni glavkom zaprtega zakotja lahko povzroči trajno izgubo vida.
English: In patients ≥65 years the incidence was 10.2% with Rasitrio versus up to 5.4% with dual combinations.
Slovenian: Pri bolnikih, ki so bili stari ≥65 let, je bila pogostnost vseh neželenih učinkov 10,2 % pri uporabi zdravila Rasitrio v primerjavi s 5,4 % pri uporabi kombinacij s samo dvema učinkovinama.
English: Use in patients with heart failure
Slovenian: Uporaba pri bolnikih s srčnim popuščanjem
English: General In the event of severe and persistent diarrhoea, Rasitrio therapy should be stopped (see section 4.8).
Slovenian: V primeru hude ali persistentne driske je treba zdravljenje z zdravilom Rasitrio prekiniti (glejte poglavje 4.8).
English: • increased sensitivity of skin to the sun
Slovenian: • povečana občutljivost kože na sončno svetlobo
English: There is no evidence that Rasitrio would reduce or prevent diuretic-induced hyponatraemia.
Slovenian: Nobenih dokazov ni, da bi zdravilo Rasitrio lahko zmanjšalo obseg ali preprečilo hiponatriemijo, ki jo sicer povzroča uporaba diuretikov.
English: • swelling mainly of the face and throat
Slovenian: • otekanje predvsem v obraz in grlo oziroma žrelo
English: Hypotension was also uncommon (<1%) during combination therapy with other antihypertensive medicinal products.
Slovenian: Hipotenzijo so občasno (pri manj kot 1 %) opažali tudi med zdravljenjem v kombinaciji z drugimi antihipertenzivnimi zdravili.
English: Amlodipine Safety data for amlodipine are well established both clinically and non-clinically.
Slovenian: Amlodipin Podatki o varnosti uporabe amlodipina so ustrezno potrjeni tako v kliničnih kot predkliničnih študijah.
English: Cases of angioedema or symptoms suggestive of angioedema (swelling of the face, lips, throat and/or tongue) have also been reported in post-marketing experience.
Slovenian: Primere angioedema oziroma simptome, ki kažejo na angioedem, (otekanje obraza, ustnic, grla oziroma žrela in/ali jezika) so opisovali tudi med izkušnjami v obdobju trženja zdravila.
English: If photosensitivity reaction occurs during treatment with Rasitrio, it is recommended to stop the treatment.
Slovenian: Če med zdravljenjem z zdravilom Rasitrio pride do fotosenzitivnostne reakcije, je priporočena prekinitev zdravljenja.
English: There are no specific data regarding the effect of hydrochlorothiazide in elderly patients.
Slovenian: O delovanju hidroklorotiazida pri starejših bolnikih ni specifičnih podatkov.
English: The fertility of rats was unaffected at doses of up to aliskiren 250 mg/kg/day and hydrochlorothiazide 4 mg/kg/day (see section 5.3).
Slovenian: Zdravilo ni vplivalo na plodnost podgan pri uporabi odmerkov aliskirena do 250 mg/kg/dan in hidroklorotiazida do 4 mg/kg/dan (glejte poglavje 5.3).
English: The volume or salt depletion should be corrected prior to administration of Rasitrio, or the treatment should start under close medical supervision.
Slovenian: Hipovolemijo ali primanjkljaj natrija je treba odpraviti pred dajanjem zdravila Rasitrio ali pa je treba zdravljenje uvajati pod strogim zdravniškim nadzorom.
English: Rasitrio is an effective once-a-day antihypertensive treatment in adult patients, regardless of gender, age, body mass index and ethnicity.
Slovenian: Zdravilo Rasitrio je učinkovito antihipertenzivno zdravilo za enkrat dnevno odmerjanje pri odraslih bolnikih ne glede na spol, starost, indeks telesne mase in etnično pripadnost.
English: A switch to a suitable alternative antihypertensive treatment should be carried out in advance of a planned pregnancy since Rasitrio should not be used in women planning to become pregnant.
Slovenian: Pred načrtovanjem nosečnosti je treba preiti na ustrezno drugo antihipertenzivno zdravljenje, saj ženske, ki nameravajo zanositi, ne smejo uporabljati zdravila Rasitrio.
English: 98 tablets (2x49x1, PVC/PCTFE single-unit-dose blisters)
Slovenian: 98 tablet (2x49x1, PVC/PCTFE pretisni omoti z razdelki za enkratni
English: Torasemide renal excretion is known to be mediated by organic anion transporters (OATs).
Slovenian: Znano je, da izločanje torasemida skozi ledvice posredujejo prenašalci organskih anionov (angl. organic anion transporters, OAT).
English: Therefore, caution should be exercised when aliskiren is administered with ketoconazole, verapamil or other moderate P-gp inhibitors (clarithromycin, telithromycin, erythromycin, amiodarone).
Slovenian: Zato je potrebna previdnost pri sočasni uporabi aliskirena s ketokonazolom, z verapamilom ali z drugimi zmernimi zaviralci P-gp (s klaritromicinom, s telitromicinom, z eritromicinom, z amiodaronom).
English: - Ion exchange resins
Slovenian: - Ionske izmenjevalne smole
English: In patients treated with both aliskiren and oral furosemide or torasemide, it is therefore recommended that the effects of furosemide or torasemide be monitored when initiating and adjusting furosemide, torasemide or aliskiren therapy to avoid changes in extracellular fluid volume and possible situations of volume overload (see section 4.4).
Slovenian: Zato je pri bolnikih, ki prejemajo tako aliskiren kot peroralni furosemid ali torasemid, pri uvedbi in prilagajanju zdravljenja s furosemidom, s torasemidom ali z aliskirenom priporočljivo spremljanje učinkov furosemida oziroma torasemida, da ne bi prišlo do sprememb volumna zunajceličnih tekočin in možnosti volumske preobremenitve (glejte poglavje 4.4).
English: Tell your doctor immediately if you experience the following at the beginning of your treatment: Fainting and/or light-headedness linked to low blood pressure could occur at the beginning of treatment with Rasitrio.
Slovenian: Če na začetku zdravljenja pride do katerega od naslednjih neželenih učinkov, takoj obvestite zdravika: omedlevica in/ali stemnitev pred očmi zaradi nizkega krvnega tlaka, do česar lahko prihaja na začetku zdravljenja z zdravilom Rasitrio.
English: These doses of hydrochlorothiazide in mice and rats represent 19 and 1.5 times, respectively, the maximum recommended human dose on a mg/m basis.
Slovenian: Navedeni odmerki hidroklorotiazida pri miših in podganah predstavljajo 19oziroma 1,5-kratno vrednost najvišjega priporočenega odmerka pri ljudeh, preračunano na enoto mg/m
English: Rasitrio is contraindicated in patients with hypercalcaemia and should only be used after correction of any pre-existing hypercalcaemia.
Slovenian: Zdravilo Rasitrio je kontraindicirano pri bolnikih s hiperkalciemijo in ga je mogoče uporabljati šele po korekciji morebitne že prisotne hiperkalciemije.
English: • severe allergic reaction (anaphylactic reaction)
Slovenian: • huda alergijska reakcija (anafilaktična reakcija)
English: Very limited data are available on the use of Rasitrio in patients aged 75 years or older (see section 5.2).
Slovenian: O uporabi zdravila Rasitrio pri bolnikih, ki so stari 75 let ali več, je na voljo zelo malo podatkov (glejte poglavje 5.2).
English: Concomitant administration of thiazide diuretics with subtances that also have a blood pressure lowering effect (e.g. by reducing sympathetic central nervous system activity or direct vasodilatation) may potentiate orthostatic hypotension.
Slovenian: Sočasna uporaba tiazidnih diuretikov in snovi, ki prav tako znižujejo krvni tlak (na primer z zmanjševanjem aktivnosti simpatičnega centralnega živčevja ali z direktno vazodilatacijo) lahko okrepi ortostatsko hipotenzijo.
English: The incidence of adverse events did not show any association with gender, age (with the exception of symptomatic hypotension), body mass index, race or ethnicity.
Slovenian: Pogostnost neželenih dogodkov ni bila povezana s spolom, s starostjo (z izjemo simptomatske hipotenzije), z indeksom telesne mase ter z raso ali etnično pripadnostjo.
English: - CYP3A4 inducers
Slovenian: - Induktorji CYP3A4
English: Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloraemia, hyponatraemia) and dehydration resulting from excessive diuresis.
Slovenian: Preveliko odmerjanje hidroklorotiazida je povezano s pomanjkanjem elektrolitov (s hipokaliemijo, hipokloremijo, hiponatriemijo) in z dehidracijo, do česar pride zaradi prekomernega odvajanja vode.
English: Thiazides reduce urinary calcium excretion and may cause an intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism.
Slovenian: Tiazidi zmanjšajo izločanje kalcija z urinom in lahko povzročijo občasno rahlo zvišanje koncentracije kalcija v serumu brez znanih motenj presnove kalcija.
English: In hypertensive patients with normal renal function, therapeutic doses of amlodipine resulted in a decrease in renal vascular resistance and an increase in glomerular filtration rate and effective renal plasma flow without change in filtration fraction or proteinuria.
Slovenian: Pri hipertenzivnih bolnikih z normalnim delovanjem ledvic terapevtski odmerki amlodipina zmanjšajo žilni upor v ledvicah ter povečajo hitrost glomerulne filtracije in efektivni ledvični pretok plazme, ne da bi spremenili filtracijsko frakcijo ali proteinurijo.
English: A single dose drug interaction study in healthy subjects has shown that ciclosporin (200 and 600 mg) increases Cmax of aliskiren 75 mg approximately 2.5-fold and AUC approximately 5-fold.
Slovenian: V študiji medsebojnega delovanja zdravil z enkratnim odmerjanjem pri zdravih osebah se je pokazalo, da ciklosporin (200 in 600 mg) zviša Cmax aliskirena (75 mg) približno 2,5-krat in AUC približno 5-krat.
English: Study results indicated a hazard ratio for the primary endpoint of 1.11 in favour of placebo (95% Confidence Interval: 1.00, 1.23, 2-sided p=0.05).
Slovenian: Rezultati študije so pokazali, da je pri primarnem cilju opazovanja razmerje ogroženosti (hazard ratio, HR) 1,11 v prid placeba (s 95-odstotnim intervalom zaupanja 1,00, 1,23 in z dvosmerno vrednostjo p=0,05).