FrancophonIA/ELRC3.0 huggingface dataset:
English: These are diseases which affect the bone marrow and can cause problems with normal blood cell production.
Croatian: To su bolesti koje zahvaćaju koštanu srž i mogu uzrokovati probleme sa stvaranjem normalnih krvnih stanica.
English: These cutaneous reactions have to be distinguished from soft tissue infections, sometimes occurring at injection site.
Croatian: Te reakcije na koži treba razlikovati od infekcija mekog tkiva kakve se katkad javljaju na mjestu primjene injekcije.
English: Talk to your doctor, pharmacist or nurse before using Vidaza:
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego što Vam je primijenjena Vidaza:
English: Dose adjustment due to haematological toxicity
Croatian: Prilagodba doza zbog hematološke toksičnosti
English: A survival benefit was also demonstrated in patients that had not achieved a complete/partial response following azacitidine treatment.
Croatian: Također je dokazano poboljšanje preživljenja kod bolesnika kod kojih nije postignut potpuni/djelomični odgovor nakon liječenja azacitidinom.
English: Adverse reactions are presented in the table below according to the highest frequency observed in any of the main clinical studies.
Croatian: Nuspojave su prikazane u donjoj tablici prema najvišoj učestalosti opaženoj u bilo kojem od glavnih kliničkih ispitivanja.
English: • The other ingredient is mannitol (E421).
Croatian: • Pomoćna tvar je manitol (E421).
English: The effect of known cytidine deaminase polymorphisms on azacitidine metabolism has not been formally investigated.
Croatian: Učinak poznatih polimorfizama citidin deaminaze na metabolizam azacitidina nije službeno ispitivan.
English: Before giving you Vidaza, your doctor will give you another medicine to prevent nausea and vomiting at the start of each treatment cycle.
Croatian: Prije primjene Vidaze, liječnik će Vam dati drugi lijek za sprječavanje mučnine i povraćanja na početku svakoga ciklusa liječenja.
English: Studies in mice have shown reproductive toxicity (see section 5.3).
Croatian: Ispitivanja na miševima pokazala su reproduktivnu toksičnost (vidjeti dio 5.3).
English: • if you have advanced liver cancer.
Croatian: • ako imate uznapredovali rak jetre
English: There is a greater risk of these events occurring during the first 2 cycles, after which they occur with less frequency in patients with restoration of haematological function.
Croatian: Veći je rizik za pojavu navedenih nuspojava tijekom prvih 2 ciklusa, nakon čega se javljaju s manjom učestalošću uz oporavak hematološke funkcije.
English: When more than 1 vial is needed all the above steps for preparation of the suspension should be repeated.
Croatian: Kada je potrebno više od 1 bočice, ponovite sve ranije navedene postupke za pripremu suspenzije.
English: Do not filter the suspension after reconstitution.
Croatian: Ne filtrirajte suspenziju nakon rekonstitucije.
English: EXP Read the leaflet for the shelf life of the reconstituted medicine.
Croatian: EXP Pročitajte uputu o lijeku za rok valjanosti rekonstituiranog lijeka.
English: Pack size: 1 vial
Croatian: Veličina pakiranja: 1 bočica
English: Therefore, caution is recommended when driving or operating machines.
Croatian: Stoga se preporučuje oprez pri upravljanju vozilima ili radu sa strojevima.
English: Total dose (mg) = Dose (mg/m2) x BSA (m2)
Croatian: Ukupna doza (mg) = doza (mg/m2) x PT (m2)
English: • Hair loss.
Croatian: • gubitak kose
English: Adult population aged 65 years or older with AML with > 30% marrow blasts
Croatian: Odrasla populacija u dobi od 65 ili više godina s AML-om s > 30 % blasta u koštanoj srži
English: Vidaza plus BSC (n=241) was compared to CCR.
Croatian: Vidaza uz BSC (n = 241) bila je uspoređena s CCR-om.
English: Incompatibilities
Croatian: Inkompatibilnosti
English: Administration of azacitidine to male mice prior to mating with untreated female mice resulted in decreased fertility and loss of offspring during subsequent embryonic and postnatal development.
Croatian: Primjena azacitidina na mužjacima miševa prije parenja s neliječenim ženkama rezultirala je smanjenjem plodnosti i gubitkom potomaka tijekom daljnjeg embrijskog i postnatalnog razvoja.
English: Vidaza treatment should be initiated and monitored under the supervision of a physician experienced in the use of chemotherapeutic agents.
Croatian: Liječenje Vidazom treba započeti i nadzirati liječnik iskusan u primjeni kemoterapijskih lijekova.
English: • Reduced red blood count (anaemia).
Croatian: • smanjen broj crvenih krvnih stanica (anemija).
English: Health- Related Quality of Life (HRQoL) was assessed using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30).
Croatian: Health-Related Quality of Life, HRQoL) bila je procijenjena pomoću glavnog upitnika o kvaliteti života Europske organizacije za istraživanje i liječenje raka (engl.
English: To re-suspend, vigorously roll the syringe between the palms until a uniform, cloudy suspension is achieved.
Croatian: Za resuspenziju, energično valjajte štrcaljku među dlanovima dok se ne dobije jednolična mutna suspenzija.
English: The Vidaza suspension may be prepared immediately before use and the reconstituted suspension should be administered within 45 minutes.
Croatian: Suspenzija Vidaze može se pripremiti neposredno prije primjene te rekonstituiranu suspenziju treba primijeniti unutar 45 minuta.
English: Vidaza is a cytotoxic medicinal product and, as with other potentially toxic compounds, caution should be exercised when handling and preparing azacitidine suspensions.
Croatian: Vidaza je citotoksični lijek te je, kao i s drugim potencijalno toksičnim tvarima, potreban oprez pri rukovanju i pripremi suspenzija azacitidina.
English: These complications are caused by the product of dying cancer cells and may include the following: changes to blood chemistry; high potassium, phosphorus, uric acid, and low calcium consequently leading to changes in kidney function, heartbeat, seizures, and sometimes death.
Croatian: Ove komplikacije prouzročene su produktima stanica raka koje odumiru i mogu uključivati sljedeće: promjene u kemijskom sastavu krvi; povišeni kalij, fosfor i mokraćnu kiselinu te sniženi kalcij, što posljedično vodi do promjena u funkciji bubrega, srčanog ritma, napadaja i ponekad smrti.
English: • Pain in your belly (abdominal pain).
Croatian: • bol u trbuhu (abdominalna bol)
English: Patients should be advised to promptly report febrile episodes.
Croatian: Bolesnike treba uputiti da što prije prijave epizode vrućice.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu/.
English: As part of the inclusion criteria, patients were required to have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
Croatian: Kao dio kriterija za uključenje, bolesnici su trebali imati indeks stanja zdravlja prema ljestvici Istočne kooperativne onkološke skupine (ECOG) 0-2.
English: Developmental abnormalities in the brain have been detected in mice given azacitidine on or before closure of the hard palate.
Croatian: Otkrivene su razvojne abnormalnosti mozga kod miševa kod kojih je azacitidin primijenjen prije ili tijekom zatvaranja tvrdog nepca.
English: Although there are some confounding factors, e.g. underlying cancerous conditions of the patients and the presence of other risk factors such as infection and history of cardiac disorders, there are other factors that strengthen this signal, including positive re-challenge, and imbalance in the pooled clinical trials between active and control arms.
Croatian: Iako postoji nekoliko zbunjujućih čimbenika, npr. istovremeno prisutna kancerozna stanja bolesnika i postojanje drugih rizičnih čimbenika poput infekcije i srčanih poremećaja u anamnezi, postoje i drugi čimbenici koji pojačavaju signal, uključujući pozitivno ponovno izlaganje lijeku i neravnotežu u sakupljenim i analiziranim rezultatima kliničkih ispitivanja između aktivne i kontrolne skupine.
English: Before starting treatment, male patients should be advised to seek counselling on sperm storage.
Croatian: Prije početka liječenja bolesnike treba upozoriti da potraže savjet o pohrani sjemena.
English: Driving and using machines Do not drive or use any tools or machines if you experience side effects, such as tiredness.
Croatian: Nemojte upravljati vozilima i raditi alatima ili strojevima ako osjećate nuspojave poput umora.
English: • The active substance is azacitidine.
Croatian: • Djelatna tvar je azacitidin.
English: The contents of the dosing syringe must be re-suspended immediately prior to administration.
Croatian: Sadržaj štrcaljke za doziranje treba ponovno resuspendirati neposredno prije primjene.
English: For clinical management of infectious adverse reactions, see section 4.8 Infections.
Croatian: Za kliničko zbrinjavanje infekcija nastalih kao nuspojave, vidjeti dio 4.8 Infekcije.
English: Treatment of male rats resulted in decreased weight of the testes and epididymides, decreased sperm counts, decreased pregnancy rates, an increase in abnormal embryos and increased loss of embryos in mated females (see section 4.4).
Croatian: Liječenje mužjaka štakora rezultiralo je smanjenjem težine testisa i epididimisa, smanjenjem broja spermija, smanjenjem stopa graviditeta i povećanjem broja abnormalnih embrija te povećanim gubitkom embrija u gravidnih ženki (vidjeti dio 4.4).
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA
English: In studies to assess inhibition of a series of P450 isoenzymes (CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4) azacitidine up to 100 μM did not produce inhibition.
Croatian: U ispitivanjima kojima se procjenjivala inhibicija serije P450 izoenzima (CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 i 3A4) azacitidin u koncentraciji do 100 µM nije izazvao inhibiciju.
English: Early embryotoxicity studies in mice revealed a 44 % frequency of intrauterine embryonal death (increased resorption) after a single intraperitoneal injection of azacitidine during organogenesis.
Croatian: U ispitivanjima rane embriotoksičnosti kod miševa zabilježena je učestalost intrauterine embrijske smrti (povećana resorpcija) od 44 % nakon jedne intraperitonejske injekcije azacitidina za trajanja organogeneze.
English: Treatment with azacitidine is associated with anaemia, neutropenia and thrombocytopenia, particularly during the first 2 cycles (see section 4.8).
Croatian: Liječenje azacitidinom povezano je s anemijom, neutropenijom i trombocitopenijom, osobito tijekom prva 2 ciklusa (vidjeti dio 4.8).
English: RAEB-T patients (21-30 % blasts) are now considered to be AML patients under the current WHO classification system.
Croatian: Bolesnici s RAEB-T (21-30 % blasta) danas se, prema važećoj klasifikacijskom sustavu SZO-a, smatraju bolesnicima s AML-om.
English: SPECIAL PRECAUTIONS FOR DISPOSAL OF UNUSED MEDICINAL PRODUCTS
Croatian: POSEBNE MJERE ZA ZBRINJAVANJE NEISKORIŠTENOG LIJEKA ILI
English: • Sleepiness, drowsiness (somnolence).
Croatian: • pospanost, omamljenost (somnolencija)
English: Pericarditis is the most reported PT (n=35 cases) followed by endocarditis (n=10) and myocarditis (n=9).
Croatian: Preferred Term, PT) (n=35 slučajeva) kojem slijedi endokarditis (n=10) i miokarditis (n=9).
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 17 December 2008
Croatian: Datum prvog odobrenja: 17. prosinca 2008.
English: Women of childbearing potential / Contraception in males and females Women of childbearing potential and men have to use effective contraception during and up to 3 months after treatment.
Croatian: Žene reproduktivne dobi / Kontracepcija u muškaraca i žena Žene u reproduktivnoj dobi i muškarci moraju primjenjivati učinkovitu kontracepciju za vrijeme i do 3 mjeseca nakon liječenja.
English: Tumour lysis syndrome
Croatian: Sindrom lize tumora
English: Patients were pre-selected by their physician to 1 of the 3 CCRs prior to randomization.
Croatian: Bolesnike je prethodno odabrao njihov liječnik za 1 od 3 CCR-a prije randomizacije.
English: What Vidaza contains
Croatian: Što Vidaza sadrži
English: Men should not father a child while receiving treatment with Vidaza.
Croatian: Muškarci ne smiju začeti dijete tijekom liječenja Vidazom.
English: Taking into account the PRAC Assessment Report on the PSUR(s) for azacitidine, the scientific conclusions of CHMP are as follows:
Croatian: Uzimajući u obzir PRAC-ovo izvješće o ocjeni periodičkog(ih) izvješća o neškodljivosti lijeka (PSUR) za azacitidin znanstveni zaključci CHMP-a su sljedeći:
English: The temperature of the suspension at the time of injection should be approximately 20 ºC-25 ºC.
Croatian: Temperatura suspenzije u vrijeme ubrizgavanja treba biti otprilike 20 ºC-25 ºC.
English: • Allergic (hypersensitivity) reaction.
Croatian: • alergijska reakcija (preosjetljivost)
English: A survival benefit was also demonstrated in patients that had not achieved a complete response for Vidaza compared to CCR.
Croatian: Korist za preživljenje također je bila dokazana u bolesnika koji nisu bili postigli potpuni odgovor na Vidazu u usporedbi s CCR-om.
English: Patients should be advised to report oliguria and anuria to the health care provider immediately.
Croatian: Bolesnicima treba savjetovati da zdravstvenom djelatniku odmah prijave oliguriju i anuriju.
English: The plunger should then be pulled back to withdraw the amount of medicinal product required for the proper dose, making sure to purge any air trapped within the syringe.
Croatian: Klip treba povući prema natrag kako bi se u štrcaljku povukla količina lijeka potrebna za odgovarajuću dozu, osiguravajući da se istisne sav zrak iz štrcaljke.
English: Soft tissue infections, including cellulitis and necrotising fasciitis in rare cases leading to death, have been reported with azacitidine in the post marketing setting.
Croatian: Infekcije mekog tkiva, uključujući celulitis i nekrotizirajući fasciitis koji u rijetkim slučajevima dovodi do smrti, zabilježene su za azacitidin poslije stavljanja lijeka u promet.
English: The absolute bioavailability of azacitidine after subcutaneous relative to intravenous administration (single 75 mg/m2 doses) was approximately 89% based on area under the curve (AUC).
Croatian: Apsolutna bioraspoloživost azacitidina nakon supkutane primjene u odnosu na intravensku primjenu (jednokratnih doza od 75 mg/m2) bila je približno 89 % na osnovi površine ispod krivulje (AUC).
English: HRQoL data could be analysed for a subset of the full trial population.
Croatian: Podaci o kvaliteti života vezanoj za zdravlje (HRQoL) mogli su se analizirati za jednu podskupinu cjelokupne ispitivane populacije.
English: In case of an anaphylactic-like reaction, treatment with azacitidine should be immediately discontinued and appropriate symptomatic treatment initiated.
Croatian: U slučaju reakcije slične anafilaktoidnoj reakciji, liječenje azacitidinom treba odmah prekinuti i započeti primjereno simptomatsko liječenje.
English: There is limited safety information available with azacitidine in patients ≥85 years (with 14 [5.9%] patients ≥85 years in AZA-AML-001 study).
Croatian: Dostupni podaci o sigurnosti primjene azacitidina u bolesnika u dobi od ≥85 godina (s 14 [5,9%] bolesnika u dobi od ≥85 godina u ispitivanju AZA-AML-001) su ograničeni.
English: Haematological toxicity
Croatian: Hematološka toksičnost
English: Azacitidine induced tumours of the haematopoietic system in female mice, when administered intraperitoneally 3 times per week for 52 weeks.
Croatian: Azacitidin je inducirao tumore hematopoetskog sustava kod ženki miševa nakon intraperitonejske primjene 3 puta tjedno tijekom 52 tjedna.
English: This medicinal product must not be mixed with other medicinal products except those mentioned in section 6.6.
Croatian: Lijek se ne smije miješati s drugim lijekovima osim onih navedenih u dijelu 6.6. 6.3 Rok valjanosti
English: Therefore, CYP enzyme induction or inhibition by azacitidine at clinically achievable plasma concentrations is unlikely.
Croatian: Stoga indukcija ili inhibicija enzima CYP klinički dosežnim koncentracijama azacitidina u plazmi nije vjerojatna.
English: Talk to your doctor or nurse if you have any questions about how Vidaza works or why this medicine has been prescribed for you.
Croatian: Razgovarajte sa svojim liječnikom ili medicinskom sestrom ako imate pitanja o tome kako djeluje Vidaza ili zašto
English: The patients at risk of tumour lysis syndrome are those with high tumour burden prior to treatment.
Croatian: Bolesnici sa rizikom od sindroma lize tumora su oni koji imaju veliko opterećenje tumorskom masom prije liječenja.
English: • Bleeding inside your head.
Croatian: • krvarenje u glavi
English: The most common serious adverse reactions noted from the pivotal study (AZA PH GL 2003 CL 001) included febrile neutropenia (8.0 %) and anaemia (2.3 %), which were also reported in the supporting studies (CALGB 9221 and CALGB 8921).
Croatian: Najčešće ozbiljne nuspojave zabilježene u pivotalnom ispitivanju (AZA PH GL 2003 CL 001) uključivale su febrilnu neutropeniju (8,0 %) i anemiju (2,3 %), koje su također bile prijavljene u potpornim ispitivanjima (CALGB 9221 i CALGB 8921).
English: This medicine will be given to you as an injection under the skin (subcutaneously) by a doctor or nurse.
Croatian: Ovaj lijek će Vam dati liječnik ili medicinska sestra kao injekciju ispod kože (supkutano).
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu/.
English: Response was assessed by the investigator or by the Independent Review Committee (IRC).
Croatian: Odgovor su procjenjivali istraživač ili neovisno stručno povjerenstvo (engl.
English: The one-year survival rates were 46.5% in patients receiving Vidaza versus 34.3% in patients receiving CCR.
Croatian: Stope jednogodišnjeg preživljenja iznosile su 46,5 % u bolesnika koji su primali Vidazu naspram 34,3 % u bolesnika koji su primali CCR.
English: • Sore or runny nose or sinuses (sinusitis)..
Croatian: • bolan nos ili curenje iz nosa ili sinusa (sinusitis)
English: A tumorigenicity study in rats revealed an increased incidence of testicular tumours.
Croatian: U ispitivanjima tumorogenosti kod štakora zabilježena je povećana učestalost tumora testisa.
English: For later use
Croatian: Za kasniju primjenu
English: Prognostic Scoring System (IPSS),
Croatian: System, IPSS),
English: • Injection site reaction including redness, pain or a skin reaction.
Croatian: • reakcija na mjestu primjene uključujući crvenilo, bol ili kožnu reakciju
English: Psychiatric disorders insomnia confusional state, anxiety
Croatian: Psihijatrijski poremećaji nesanica konfuzno stanje, anksioznost
English: • acute myeloid leukaemia (AML).
Croatian: • akutne mijeloične leukemije (AML)
English: The cytotoxic effects of azacitidine may result from multiple mechanisms, including inhibition of DNA, RNA and protein synthesis, incorporation into RNA and DNA, and activation of DNA damage pathways.
Croatian: Citotoksična djelovanja azacitidina mogu biti rezultat brojnih mehanizama, uključujući inhibiciju sinteze DNK-a, RNK-a i proteina, ugrađivanje u RNK i DNK te aktivaciju puteva oštećenja DNK-a.
English: Winthontlaan 6 N 3526 KV Utrecht Netherlands
Croatian: Winthontlaan 6 N 3526 KV Utrecht Nizozemska
English: The median age of the subjects was 75.0 years (range: 64 to 91 years), 75.2% were Caucasian and 59.0% were male.
Croatian: Medijan dobi ispitanika bio je 75,0 godina (raspon: od 64 do 91 godine), 75,2 % bili su bijelci i 59,0 % bili su muškarci.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each vial contains 100 mg azacitidine.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Svaka bočica sadrži 100 mg azacitidina.
English: Azacitidine becomes incorporated into the genetic material of cells (ribonucleic acid (RNA) and deoxyribonucleic acid (DNA)).
Croatian: Azacitidin se sjedinjuje s genetičkim materijalom stanica (ribonukleinskom kiselinom (RNK) i deoksiribonukleinskom kiselinom (DNK)).
English: Following intravenous and subcutaneous administration of 14C-azacitidine, 85 and 50 % of the administered radioactivity was recovered in urine respectively,
Croatian: Nakon intravenske i supkutane primjene 14C-azacitidina, 85 i 50 % primijenjene radioaktivnosti nađeno je u urinu, dok je < 1 %
English: The relative importance of DNA hypomethylation versus cytotoxicity or other activities of azacitidine to clinical outcomes has not been established.
Croatian: Relativna važnost hipometilacije DNK-a naspram citotoksičnosti ili drugih djelovanja na kliničke ishode azacitidina nije ustanovljena.
English: No formal clinical drug interaction studies with azacitidine have been conducted.
Croatian: Nisu provedena službena klinička ispitivanja interakcija s azacitidinom.
English: On the basis of the scientific conclusions for azacitidine the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing azacitidine is unchanged subject to the proposed changes to the product information
Croatian: Na temelju znanstvenih zaključaka za azacitidin, CHMP smatra da je omjer koristi i rizika lijeka(ova) koji sadrži(e) azacitidin nepromijenjen, uz predložene izmjene informacija o lijeku.
English: No specific modification to the starting dose is recommended for patients with hepatic impairment prior to starting treatment; subsequent dose modifications should be based on haematology laboratory values.
Croatian: Kod bolesnika s oštećenjem jetre prije početka liječenja nisu preporučene posebne izmjene početne doze; naknadne izmjene doza treba temeljiti na hematološkim laboratorijskim pokazateljima.
English: The rubber top should be cleaned and a new syringe with needle inserted into the vial.
Croatian: Gumeni čep treba obrisati i u bočicu umetnuti novu štrcaljku s iglom.
English: Vidaza works by preventing cancer cells from growing.
Croatian: Vidaza djeluje tako što sprječava rast tumorskih stanica.
English: The Cox PH model adjusted for pre-specified baseline prognostic factors defined a HR for Vidaza versus CCR of 0.80 (95% CI= 0.66, 0.99; p = 0.0355).
Croatian: Prema Coxovu modelu prilagođenom za prije određene početne prognostičke faktore, određen je omjer hazarda za Vidazu u usporedbi s CCR-om od 0,80 (95% CI = 0,66; 0,99; p = 0,0355).
English: This may be due to an infection of the lung called “pneumonia”, and can be life-threatening.
Croatian: To može nastati zbog infekcije pluća odnosno „pneumonije“ i može biti opasno po život.
English: Patients should be premedicated with anti-emetics for nausea and vomiting.
Croatian: Bolesnicima u premedikaciji treba dati antiemetike zbog mučnine i povraćanja.
English: If bone marrow cellularity is ≤ 50 %, treatment should be delayed and the dose reduced according to the following table:
Croatian: Ako je celularnost koštane srži ≤ 50 %, liječenje treba odgoditi i dozu smanjiti prema sljedećoj tablici:
English: • chronic myelomonocytic leukaemia (CMML) with 10-29 % marrow blasts without myeloproliferative disorder,
Croatian: • kronične mijelomonocitne leukemije (KMML) s 10-29 % blasta u koštanoj srži bez mijeloproliferativnog poremećaja,
English: There are no adequate data from the use of azacitidine in pregnant women.
Croatian: Nema odgovarajućih podataka o primjeni azacitidina u trudnica.
English: For immediate use
Croatian: Za neposrednu primjenu
English: Procedures for proper handling and disposal of anticancer medicinal products should be applied.
Croatian: Treba primijeniti postupke za pravilno rukovanje i odlaganje antitumorskih lijekova.
English: Following removal of the syringe and needle, the vial should be vigorously shaken until a uniform cloudy suspension is achieved.
Croatian: Nakon uklanjanja štrcaljke i igle, bočicu treba energično protresti dok se ne dobije jednolična mutna suspenzija.