FrancophonIA/ELRC3.0 huggingface dataset:
English: Repeat infusion every 12-24 hours for 3-4 days or more until pain and acute disability are resolved
Croatian: Ponavljati infuziju svakih 12-24 sata tijekom 3-4 dana ili dulje, do prestanka boli i akutne onesposobljenosti.
English: Every 24 hours, at least 1 day, until healing is achieved
Croatian: Svaka 24 sata tijekom najmanje 1 dana, do zacijeljenja.
English: Place the vial on a flat and solid surface.
Croatian: Stavite bočicu na ravnu i čvrstu podlogu.
English: During the course of treatment, appropriate determination of factor VIII levels is advised to guide the dose to be administered and the frequency of repeated injections.
Croatian: Tijekom liječenja preporučuje se odgovarajuće određivanje razina faktora VIII kako bi se mogla odrediti doza koju treba primijeniti i učestalost ponavljanja injekcija.
English: If a central venous access device (CVAD) is required, risk of CVAD-related complications including local infections, bacteraemia and catheter site thrombosis should be considered.
Croatian: Ako je potreban centralni venski pristup, treba uzeti u obzir rizik od komplikacija povezanih s centralnim venskim pristupom uključujući lokalne infekcije, bakterijemiju te trombozu na mjestu kateterizacije.
English: Any unused reconstituted product stored at room temperature (≤30°C) or up to 40°C for more than 4 hours should be discarded.
Croatian: Neiskorišteni rekonstituirani lijek koji je čuvan na sobnoj temperaturi (≤30°C) ili do 40°C dulje od 4 sata mora se baciti.
English: By replacement therapy the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of bleeding tendencies.
Croatian: Nadomjesnom terapijom povećavaju se razine faktora VIII u plazmi, čime se omogućuje privremena korekcija nedostatka faktora te korekcija sklonosti krvarenju.
English: Mean (SD) Min ; Max Success ratea
Croatian: Min; Maks Stopa uspješnostia
English: Turoctocog alfa (human coagulation factor VIII (rDNA)) is a purified protein that has 1,445 amino acids with an approximate molecular mass of 166 kDA.
Croatian: Turoktokog alfa (humani koagulacijski faktor VIII (rDNK)) je pročišćen protein koji sadrži 1445 aminokiselina i čija molekulska masa iznosi približno 166 kDA.
English: During storage, the product may be kept at:
Croatian: Tijekom čuvanja, lijek možete držati:
English: In the case of the following haemorrhagic events, the factor VIII activity should not fall below the given plasma activity level (in % of normal or IU/dl) in the corresponding period.
Croatian: U slučaju sljedećih događaja krvarenja, aktivnost faktora VIII ne smije pasti ispod navedene razine aktivnosti u plazmi (izražene u % normalne vrijednosti ili u IU/dl) u odgovarajućem razdoblju.
English: In case you only need part of the entire vial, use the scale on the syringe to see how much reconstituted solution you withdraw, as instructed by your doctor or nurse.
Croatian: Ako trebate samo dio sadržaja bočice, pomoću skale na štrcaljki odredite koliko rekonstituirane otopine ćete izvući, u skladu s uputama koje ste dobili od liječnika ili medicinske sestre.
English: Sodium chloride Water for injections
Croatian: natrijev klorid voda za injekcije
English: Factor VIII inhibitors make NovoEight less effective in preventing or controlling bleeding.
Croatian: Inhibitori faktora VIII umanjuju djelotvornost lijeka NovoEight u sprječavanju ili kontroli krvarenja.
English: Based on the rare occurrence of haemophilia A in women, experience regarding the use of factor VIII during pregnancy and breastfeeding is not available.
Croatian: Budući da se hemofilija A rijetko javlja u žena, iskustva s primjenom faktora VIII tijekom trudnoće i dojenja nisu dostupna.
English: During clinical trial in PUPs, 21 patients were treated with ITI and 18 (86%) patients completed ITI with a negative inhibitor test result.
Croatian: Tijekom kliničkog ispitivanja u prethodno neliječenih bolesnika, 21 bolesnik bio je u postupku ITI-a, te je 18 (86%) bolesnika završilo ITI s negativnim rezultatom testa na inhibitore.
English: The tyrosine sulphation site present at Tyr1680 (native full length), which is important for the binding to von Willebrand factor, has been found to be fully sulphated in the turoctocog alfa molecule.
Croatian: Utvrđeno je da je mjesto sulfatacije tirozina prisutno na Tyr1680 (prirodna puna duljina), koje je važno za vezivanje za von Willebrandov faktor, potpuno sulfatirano u molekuli turoktokoga alfa.
English: In patients with existing cardiovascular risk factors, substitiution therapy with FVIII may increase the cardiovascular risk.
Croatian: U bolesnika s postojećim faktorima rizika za kardiovaskularne događaje nadomjesna terapija faktorom VIII može povećati kardiovaskularni rizik.
English: Surgery There is limited experience of surgery in paediatric patients.
Croatian: Iskustvo kod kirurških zahvata u pedijatrijskih bolesnika je ograničeno.
English: NovoEight replaces this faulty or missing ‘factor VIII' and helps blood to form clots at the site of bleeding.
Croatian: NovoEight zamjenjuje taj „faktor VIII“ koji nedostaje ili ne djeluje pravilno te pomaže u stvaranju krvnih ugrušaka na mjestu krvarenja.
English: An increase in dose may be required for underweight patients (BMI <18.5 kg/m2) and a decrease in dose may be required for obese patients (BMI ≥30 kg/m2), but there is insufficient data to recommend specific dose adjustments, see section 5.2.
Croatian: Povećanje doze može biti potrebno u bolesnika s premalom tjelesnom masom (ITM <18,5 kg/m2), a smanjenje doze može biti potrebno u pretilih bolesnika (ITM ≥30 kg/m2), ali nema dovoljno podataka da bi se preporučilo specifično prilagođavanje doze, vidjeti dio 5.2.
English: For children not previously treated with Factor VIII medicines, inhibitor antibodies (see section 2) may form very commonly (more than 1 in 10 patients); however patients who have received previous treatment with Factor VIII (more than 150 days of treatment) the risk is uncommon (less than 1 in 100 patients).
Croatian: U djece koja se prethodno nisu liječila lijekovima koji sadrže faktor VIII, inhibicijska protutijela (pogledajte dio 2.) mogu se stvarati vrlo često (u više od 1 na 10 bolesnika); međutim, rizik stvaranja protutijela je manje čest (u manje od 1 na 100 bolesnika) u bolesnika koji su prethodno bili liječeni faktorom VIII (više od 150 dana liječenja).
English: • redness around the site where you placed catheter • vomiting.
Croatian: • crvenilo oko mjesta gdje je uveden kateter • povraćanje
English: You will also need an infusion set (tubing and butterfly needle), sterile alcohol swabs, gauze pads and plasters.
Croatian: Trebat će Vam i infuzijski set (cjevčica i leptirasta igla), sterilni alkoholni tupferi, gaze i flasteri.
English: Excipient with known effect The medicinal product contains 30.5 mg sodium per reconstituted vial.
Croatian: Pomoćna tvar s poznatim učinkom Lijek sadrži 30,5 mg natrija po rekonstituiranoj bočici.
English: The dose of NovoEight is calculated depending on your body weight and the factor VIII levels to be achieved.
Croatian: Doza lijeka NovoEight izračunava se na temelju tjelesne težine i razina faktora VIII koje se žele postići.
English: Inject the reconstituted solution as instructed by your doctor or nurse.
Croatian: Injicirajte pripremljenu otopinu u skladu s uputama koje ste dobili od liječnika ili medicinske sestre.
English: Normal weight N=7
Croatian: Normalna tjelesna težina N=7
English: Lightly squeeze the protective cap with your thumb and index finger as shown.
Croatian: Lagano stisnite zaštitni omot palcem i kažiprstom kako je prikazano.
English: In patients with haemophilia A, factor VIII is missing or not working properly.
Croatian: U bolesnika s hemofilijom A faktor VIII nedostaje ili nema ispravnu funkciju.
English: Repeat every 12 to 24 hours, at least 1 day, until the bleeding episode as indicated by pain is resolved or healing achieved
Croatian: Ponavljati svakih 12 do 24 sata tijekom najmanje 1 dana, dok se ne zaustavi krvarenje na koje upućuje bol ili do zacijeljenja.
English: Before the NovoEight powder is reconstituted it may be kept at:
Croatian: Prije pripreme za primjenu NovoEight prašak može se čuvati:
English: The formation of inhibitors (antibodies) is a known complication that can occur during treatment with all Factor VIII medicines.
Croatian: Stvaranje inhibitora (protutijela) poznata je komplikacija koja se može pojaviti tijekom liječenja bilo kojim lijekom koji sadrži faktor VIII.
English: In some cases, especially in younger patients, shorter dosage intervals or higher doses may be necessary.
Croatian: U nekim slučajevima, osobito u mlađih bolesnika, možda će biti potrebni kraći intervali između doziranja ili veće doze.
English: NovoEight is now ready for injection.
Croatian: NovoEight je sada spreman za injiciranje.
English: For long term prophylaxis against bleeding in patients with severe haemophilia A. The usual recommended doses are 20-40 IU of factor VIII per kg body weight every second day or 20-50 IU of factor VIII per kg body weight 3 times weekly.
Croatian: Za dugotrajnu profilaksu protiv krvarenja u bolesnika s teškom hemofilijom A. Uobičajene preporučene doze iznose 20-40 IU faktora VIII po kg tjelesne težine svaki drugi dan ili 20-50 IU faktora VIII po kg tjelesne težine 3 puta na tjedan.
English: FVIII level required (%) (IU/dl)
Croatian: Potrebna razina faktora VIII (%) (IU/dl)
English: • 24 hours stored at 2°C - 8°C
Croatian: • 24 sata ako se čuva na temperaturi od 2°C-8°C
English: NovoEight can be used for all age groups.
Croatian: NovoEight se može koristiti u svim dobnim skupinama.
English: NovoEight has no influence on the ability to drive and use machines.
Croatian: NovoEight ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: - The ingredients in the solvent are sodium chloride and water for injections.
Croatian: - Sastojci u otapalu su natrijev klorid i voda za injekcije.
English: Before injection (administration) it must be reconstituted with the solvent supplied in the syringe.
Croatian: Prije injiciranja (primjene) mora biti pripremljen s otapalom koje se nalazi u štrcaljki.
English: The table presented below is according to the MedDRA system organ classification (SOC and Preferred Term Level).
Croatian: Tablica u nastavku prikazuje nuspojave prema MedDRA klasifikaciji organskih sustava (organski sustav i preporučeni pojam).
English: Grasp the plunger rod by the wide top end and take it out of the carton.
Croatian: Uhvatite potisni klip za široki gornji dio i izvadite ga iz kutije.
English: For long term prophylaxis against bleeding in patients below the age of 12, doses of 25-50 IU of factor VIII per kg body weight every second day or 25-60 IU of factor VIII per kg body weight 3 times weekly are recommended.
Croatian: Za dugotrajnu profilaksu protiv krvarenja u bolesnika mlađih od 12 godina preporučuju se doze od 25-50 IU faktora VIII po kg tjelesne težine svaki drugi dan ili 25-60 IU faktora VIII po kg tjelesne težine 3 puta na tjedan.
English: NovoEight can be used in children of all ages.
Croatian: NovoEight se može primjenjivati u djece svake dobi.
English: The medicinal product contains 30.5 mg sodium per reconstituted vial, equivalent to 1.5% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Croatian: Ovaj lijek sadrži 30,5 mg natrija po rekonstituiranoj bočici, što odgovara 1,5% maksimalnog dnevnog unosa od 2 g natrija prema preporukama Svjetske zdravstvene organizacije za odraslu osobu.
English: b Frequency is based on studies with all FVIII products which included patients with severe haemophilia A. c Injection site reactions include injection site erythema, injection site extravasation and injection site pruritus.
Croatian: b Učestalost se temelji na ispitivanjima svih lijekova s faktorom VIII koja su uključivala bolesnike s teškom hemofilijom A. c Reakcije na mjestu injiciranja uključuju eritem na mjestu injiciranja, ekstravazaciju na mjestu injiciranja i pruritus na mjestu injiciranja.
English: Remove the plastic cap from the vial.
Croatian: Uklonite plastični zatvarač s bočice.
English: In the trial with previously untreated patients, between 0 and 6 years of age, a total of 46 adverse reactions were reported in 33 of 60 patients exposed to NovoEight.
Croatian: U ispitivanju provedenom u prethodno neliječenih bolesnika u dobi od 0 do 6 godina, prijavljeno je ukupno 46 nuspojava u 33 od 60 bolesnika izloženih lijeku NovoEight.
English: The rate should be determined by the patient's comfort level.
Croatian: Brzinu infuzije treba odrediti prema razini podnošljivosti bolesnika.
English: Check the expiry date.
Croatian: Provjerite rok valjanosti.
English: Individual patients may vary in their response to factor VIII, demonstrating different half-lives and recoveries.
Croatian: Pojedini bolesnici mogu imati različite odgovore na faktor VIII, te pokazivati različite poluvijekove i prirast po jedinici doze.
English: For storage conditions of the reconstituted medicinal product see section 6.3.
Croatian: Za uvjete čuvanja rekonstituiranog lijeka, vidjeti dio 6.3.
English: The side effects observed in children and adolescents are the same as observed in adults.
Croatian: Nuspojave u djece i adolescenata Nuspojave primijećene u djece i adolescenata jednake su onima primijećenima u odraslih.
English: The single dose pharmacokinetic parameters of NovoEight are listed in Table 4 for the one-stage clotting assay and in Table 5 for the chromogenic assay.
Croatian: Farmakokinetički parametri jednokratne doze lijeka NovoEight navedeni su u Tablici 4 za jednostupanjski test koagulacije i u Tablici 5 za kromogeni test.
English: Wipe the rubber stopper on the vial with a sterile alcohol swab and allow it to air dry for a few seconds before use.
Croatian: Obrišite gumeni čep na bočici sterilnim alkoholnim tupferom i pričekajte nekoliko sekundi da se osuši na zraku prije uporabe.
English: The assay performance of NovoEight in FVIII:C assays was evaluated and compared to a marketed full length recombinant FVIII product.
Croatian: Procijenjena je primjenjivost FVIII:C testova za NovoEight te je uspoređena s lijekom na tržištu koji sadrži rekombinantni FVIII pune duljine.
English: Activated factor VIII acts as a co-factor for activated factor IX, accelerating the conversion of factor X to activated factor X. Activated factor X converts prothrombin into thrombin.
Croatian: Aktivirani faktor VIII djeluje kao kofaktor za aktivirani faktor IX te tako ubrzava pretvorbu faktora X u aktivirani faktor X.
English: • Use a clean and germ free (aseptic) technique.
Croatian: • Koristite tehniku koja osigurava čistu primjenu bez mikroorganizama (aseptična tehnika).
English: Also there can be significant discrepancies between assay results obtained by aPTT-based one stage clotting assay and the chromogenic assay according to Ph. Eur.
Croatian: Osim toga, mogu postojati značajne nepodudarnosti između rezultata dobivenih jednostupanjskim testom koagulacije koji se temelji na aPTV-u i onih dobivenih kromogenim testom prema Europskoj farmakopeji.
English: You should contact your doctor if you have missed a dose and do not know how to compensate for this.
Croatian: Ako ste zaboravili primijeniti NovoEight Obratite se svom liječniku ako ste propustili dozu i ne znate kako je nadoknaditi.
English: Turoctocog alfa is a B-domain truncated recombinant human coagulation factor VIII (B-domain consists of 21 amino acids of the wild type B-domain) without any other modifications in the amino acid sequence.
Croatian: Turoktokog alfa je rekombinantni humani koagulacijski faktor VIII sa skraćenom B-domenom (B-domena sastoji se od 21 aminokiseline B-domene divljega tipa) koji nema nikakvih drugih modifikacija u slijedu aminokiselina.
English: AUC ((IU*h)/dl) 1860 (700) 2730 (860)
Croatian: AUC ((IU*h)/dl) 1860 (700) 2730 (860) CL (ml/h/kg)
English: A single dose pharmacokinetic trial (50 IU/kg) was performed in 35 haemophilia patients (≥18 years of age) in different BMI categories.
Croatian: Farmakokinetička ispitivanja jednokratne doze (50 IU/kg) provedena su u 35 bolesnika s hemofilijom (≥18 godina) u različitim skupinama prema indeksu tjelesne mase (ITM).
English: When using an in vitro thromboplastin time (aPTT)-based one stage clotting assay for determining factor VIII activity in patients' blood samples, plasma factor VIII activity results can be significantly affected by both the type of aPTT reagent and the reference standard used in the assay.
Croatian: Kada se za određivanje aktivnosti faktora VIII u krvnim uzorcima bolesnika koristi in vitro jednostupanjski test koagulacije koji se temelji na tromboplastinskom vremenu (aPTV), na rezultate aktivnosti faktora VIII u plazmi mogu značajno utjecati i tip reagensa koji se koristi za određivanje aPTV-a i referentni standard upotrijebljen u testu.
English: Thrombosis in device a Calculated based on total number of unique patients in all clinical trials (301), of which 242 were previously treated patients (PTPs) and 60 were previously untreated patients (PUPs).
Croatian: Problemi s lijekom često nastanak tromba u uređaju a Izračunato na temelju ukupnog broja jedinstvenih bolesnika u svim kliničkim ispitivanjima (301), od kojih su 242 bila prethodno liječena, dok 60 njih prethodno nije bilo liječeno.
English: NovoEight contains sodium
Croatian: NovoEight sadrži natrij
English: Patients should be informed of the early signs of hypersensitivity reactions including hives, generalised urticaria, tightness of the chest, wheezing, hypotension and anaphylaxis.
Croatian: Bolesnike se mora upoznati s ranim znakovima reakcija preosjetljivosti, uključujući koprivnjaču, generaliziranu urtikariju, stezanje u prsištu, piskanje pri disanju, hipotenziju i anafilaksiju.
English: Table 3 Consumption of NovoEight and haemostatic success rates in previously untreated patients (PUP) and previously treated patients (PTP)
Croatian: Tablica 3 Unos lijeka NovoEight i stope hemostatske uspješnosti u prethodno neliječenih bolesnika (engl. previously untreated patients, PUP) i prethodno liječenih bolesnika (engl.
English: No symptoms of overdose with recombinant coagulation factor VIII have been reported.
Croatian: 4.9 Predoziranje Nisu prijavljeni simptomi predoziranja rekombinantnim koagulacijskim faktorom VIII.
English: Push the plunger rod slowly until all air bubbles are gone.
Croatian: Polako pritišćite potisni klip dok svi mjehurići zraka ne izađu.
English: Psychiatric disorders Uncommon
Croatian: Psihijatrijski poremećaji manje često nesanica
English: In some cases, especially in younger patients, more frequent injections or higher doses may be needed.
Croatian: U nekim slučajevima, osobito u mlađih bolesnika, injekcije će se možda morati primjenjivati češće ili u većim dozama.
English: • pain in legs and arms
Croatian: • bol u nogama i rukama
English: Keep reconstituted NovoEight solution out of direct light.
Croatian: Pripremljenu otopinu lijeka NovoEight držite podalje od izravne svjetlosti.
English: NovoEight is used to treat and prevent bleeding episodes in patients with haemophilia A (inborn factor VIII deficiency) and can be used for all age groups.
Croatian: NovoEight se koristi za liječenje i sprječavanje epizoda krvarenja u bolesnika s hemofilijom A (prirođeni nedostatak faktora VIII) i može se primjenjivati u svim dobnim skupinama.
English: During all clinical studies with NovoEight in previously treated patients, a total of 35 adverse reactions were reported in 23 of 242 patients exposed to NovoEight.
Croatian: Tijekom svih kliničkih ispitivanja lijeka NovoEight u prethodno liječenih bolesnika prijavljeno je ukupno 35 nuspojava u 23 od 242 bolesnika izložena lijeku NovoEight.
English: Plastic cap
Croatian: Plastični zatvarač
English: Mean residence time (h) a BMI groups: Underweight: BMI <18.5 kg/m2, Normal weight: BMI 18.5-24.9 kg/m2, Overweight: BMI 25-29.9 kg/m2, Obese class I: BMI 30-34.9 kg/m2, Obese class II/III: BMI ≥35 kg/m2.
Croatian: Cmax (IU/dl) Srednja vrijednost vremena zadržavanja(h) a ITM skupina: Ispod normalne tjelesne težine: ITM <18,5 kg/m2, Normalna tjelesna težina: ITM 18,5-24,9 kg/m2, Prekomjerna tjelesna težina: ITM 25-29,9 kg/m2; Pretilost I. stupnja: ITM 30-34,9 kg/m2; Pretilost II./III. stupnja: ITM ≥35 kg/m2.
English: Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Croatian: Liječenje i profilaksa krvarenja u bolesnika s hemofilijom A (prirođeni nedostatak faktora VIII).
English: Early signs of allergic reactions are rash, hives, weals, generalised itching,
Croatian: Rani znakovi alergijskih reakcija su osip, koprivnjača, urtike,
English: Spike (under protective paper)
Croatian: (ispod zaštitnog papira)
English: Data on Immune Tolerance Induction (ITI) has been collected in patients with haemophilia A who had developed inhibitors to factor VIII.
Croatian: Immune Tolerance Induction, ITI) prikupljeni su u bolesnika s hemofilijom A koji su razvili inhibitore faktora VIII.
English: Frequencies have been evaluated according to the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare
Croatian: Učestalost pojavljivanja definirana je kao: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često
English: Bring the vial and the pre-filled syringe to room temperature.
Croatian: Bočica i napunjena štrcaljka trebaju postići sobnu temperaturu.
English: The solvent is a sodium chloride 9 mg/ml (0.9%) solution.
Croatian: Otapalo je 0,9%-tna otopina natrijeva klorida (9 mg/ml).
English: - 1 glass vial (type I) with powder and chlorobutyl rubber stopper - 1 sterile vial adapter for reconstitution - 1 pre-filled syringe of 4 ml solvent with backstop (polypropylene), a rubber plunger
Croatian: - 1 staklenu bočicu (staklo tipa I) s praškom i čepom od klorbutilne gume - 1 sterilni nastavak za bočicu za rekonstituciju - 1 napunjenu štrcaljku s 4 ml otapala s graničnikom (polipropilen), gumenim klipom (brombutil)
English: The maximum exposure (Cmax) and the total exposure (AUC) increase with increasing BMI indicating that dose adjustments may be required for underweight (BMI <18.5 kg/m2) and obese patients (BMI ≥30 kg/m2), see section 4.2.
Croatian: Rast maksimalne izloženosti (Cmax) i ukupne izloženosti (AUC) s porastom ITM ukazuje da mogu biti potrebne prilagodbe doza u bolesnika ispod normalne tjelesne težine (ITM <18,5 kg/m2) i u pretilih bolesnika (ITM ≥30 kg/m2), vidjeti dio 4.2.
English: The analysis of plasma samples was conducted using both the one-stage clotting assay and the chromogenic assay.
Croatian: Analiza uzoraka plazme provedena je primjenom i jednostupanjskog testa koagulacije i kromogenog testa.
English: Sinus tachycardia, acute myocardial infarction
Croatian: Srčani poremećaji manje često sinusna tahikardija, akutni infarkt miokarda
English: Do not stop using NovoEight without talking to your doctor.
Croatian: Nemojte prestati primjenjivati NovoEight bez savjetovanja s liječnikom.
English: swelling of lips and tongue, difficulty in breathing, wheezing, tightness of the chest, general feeling of being unwell, and dizziness.
Croatian: svrbež po cijelom tijelu, oticanje usana i jezika, otežano disanje, piskanje pri disanju, stezanje u prsima, opće loše stanje i omaglica.
English: If a larger dose is needed, repeat steps A to J with additional vials, vial adapters and pre-filled syringes.
Croatian: Ako je potrebna veća doza, ponovite korake A do J s dodatnim bočicama, nastavcima za bočicu i napunjenim štrcaljkama.
English: • blood tests showing changes in the way the liver functions • reactions (redness and itching) around the site where you injected the medicine.
Croatian: • reakcije (crvenilo i svrbež) oko mjesta u koje ste injicirali lijek.
English: It is recommended to use NovoEight immediately after reconstitution.
Croatian: Preporučuje se NovoEight primijeniti odmah nakon rekonstitucije.
English: Table 1 Guide for dosing in bleeding episodes and surgery
Croatian: Tablica 1 Vodič za doziranje kod epizoda krvarenja i kirurških zahvata Stupanj krvarenja/vrsta kirurškog zahvata