FrancophonIA/ELRC3.0 huggingface dataset:
English: EU/1/15/992/001 1 x 3 ml EU/1/15/992/002 3 x 3 ml EU/1/15/992/003 5 x 3 ml
Croatian: EU/1/15/992/003 5 x 3 ml
English: The pen is designed to be used with NovoFine or NovoTwist disposable needles up to a length of 8 mm and as thin as 32G.
Croatian: Brizgalica je namijenjena uporabi s jednokratnim iglama NovoFine ili NovoTwist duljine do 8 mm i ne tanjim od 32G.
English: In a clinical trial in overweight or obese patients with type 2 diabetes mellitus treated with Saxenda in combination with diet and exercise, severe hypoglycaemia (requiring third party assistance) was reported by 0.7% of patients treated with Saxenda and only in patients concomitantly treated with sulfonylurea.
Croatian: U kliničkom ispitivanju na bolesnicima s prekomjernom tjelesnom težinom ili pretilim bolesnicima sa šećernom bolešću tipa 2 koji su liječeni lijekom Saxenda u kombinaciji s dijetom i tjelovježbom tešku hipoglikemiju (koja zahtijeva pomoć druge osobe) prijavilo je 0,7% bolesnika liječenih lijekom Saxenda i to su bili isključivo bolesnici koji su istodobno liječeni sulfonilurejom.
English: Saxenda is not recommended for use in patients with severe hepatic impairment and should be used cautiously in patients with mild or moderate hepatic impairment (see sections 4.4 and 5.2).
Croatian: Primjena lijeka Saxenda ne preporučuje se u bolesnika s teškim oštećenjem jetre te se treba primjenjivati s oprezom u bolesnika s blagim ili umjerenim oštećenjem jetre (vidjeti dijelove 4.4 i 5.2).
English: Baseline values are means, changes from baseline at week 32 are estimated means (leastsquares) and treatment contrasts at week 32 are estimated treatment differences (95% CI).
Croatian: Početne vrijednosti predstavljaju srednje vrijednosti, promjene od početne vrijednosti u 32. tjednu predstavljaju procijenjene srednje vrijednosti (najmanji kvadrati), a kontrasti liječenja u 32. tjednu predstavljaju procijenjene razlike liječenja (95% CI).
English: • Delay in the emptying of the stomach
Croatian: • Odgođeno pražnjenje želuca
English: Your doctor will start you on a diet and exercise programme.
Croatian: Prema uputama svog liječnika započet ćete program dijete i tjelovježbe.
English: Figure 1 Change from baseline in body weight (%) by time in trial 1 (0-56 weeks)
Croatian: Slika 1 Promjena od početne vrijednosti u tjelesnoj težini (%) u odnosu na vrijeme u 1. ispitivanju (0. do 56. tjedna)
English: Proportion of patients losing ≥5% body weight at week 32, % (95% CI) Proportion of patients losing >10% body weight at week 32 % (95% CI)
Croatian: Udio bolesnika koji su izgubili ≥5% tjelesne težine u 32. tjednu, % (95% CI) Udio bolesnika koji su izgubili >10% tjelesne težine u 32. tjednu, % (95% CI)
English: Exposure associated with 3.0 mg liraglutide was found to be comparable between the children aged 7 to 11, adolescents and adult subjects, after correction for body weight.
Croatian: Nakon prilagodbe za tjelesnu težinu, izloženost povezana s liraglutidom od 3,0 mg bila je usporediva između djece u dobi od 7 do 11 godina, adolescenata i odraslih.
English: 1 ml solution for injection contains 6 mg liraglutide.
Croatian: 1 ml otopine za injekciju sadrži 6 mg liraglutida.
English: Store in a refrigerator
Croatian: POSEBNE MJERE ČUVANJA Čuvati u hladnjaku.
English: Liraglutide exposure was decreased by 13-23% in patients with mild to moderate hepatic impairment compared to healthy subjects.
Croatian: U usporedbi sa zdravim ispitanicima, izloženost liraglutidu bila je smanjena za 13-23% kod bolesnika s blagim do umjerenim oštećenjem jetre.
English: ***See section 4.4.
Croatian: (vidjeti sliku 4).
English: In trial 2, 50.4% achieved ≥5% weight loss after 12 weeks.
Croatian: U 2. ispitivanju 50,4% postiglo je smanjenje tjelesne težine ≥5% nakon
English: For body weight, HbA1c, FPG, blood pressure and waist circumference, baseline values are means, changes from baseline at week 160 are estimated means (least-squares) and treatment contrasts at week
Croatian: Početne vrijednosti za tjelesnu težinu, HbA1c, FPG, krvni tlak i opseg struka predstavljaju srednje vrijednosti, promjene od početne vrijednosti u 160. tjednu predstavljaju procijenjene srednje vrijednosti (najmanji kvadrati), a kontrasti liječenja u 160. tjednu predstavljaju procijenjene razlike liječenja.
English: The 56-week part of trial 1 assessed body weight loss in all the 3,731 randomised patients (2,590 completers).
Croatian: U 56-tjednom dijelu 1. ispitivanja procijenjen je gubitak tjelesne težine u svih 3731
English: There is little experience with this medicine in patients with kidney problems.
Croatian: Malo je iskustva s primjenom ovog lijeka u bolesnika koji imaju probleme s bubrezima.
English: Saxenda contains less than 1 mmol sodium (23 mg) per dose, therefore the medicinal product is essentially ‘sodium-free'.
Croatian: Saxenda sadrži manje od 1 mmol (23 mg) natrija po dozi, tj. zanemarive količine natrija.
English: Children and adolescents
Croatian: Pogledajte dio 4. Djeca i adolescenti
English: • Before you use the pen for the first time, your doctor or nurse will show you how to use the pen.
Croatian: Kako i kada primjenjivati lijek Saxenda • Prije prve uporabe brizgalice liječnik ili medicinska sestra pokazat će Vam kako je upotrebljavati.
English: Patients were randomly allocated to either liraglutide on a daily dose of up to 1.8 mg (4,668) or placebo (4,672), both on a background of standard of care.
Croatian: Bolesnicima su uz osnovno standardno liječenje randomizirano dodijeljeni liraglutid jednom dnevno do 1,8 mg (4668) ili placebo
English: All 3,731 patients were randomised to 56 weeks of treatment and the 2,254 patients with pre-diabetes at screening were randomised to 160 weeks of treatment.
Croatian: Svih 3731 bolesnika randomizirano je na 56 tjedana liječenja te je
English: Excipients: disodium phosphate dihydrate, propylene glycol, phenol, hydrochloric acid/sodium hydroxide (for pH adjustment), water for injections
Croatian: POPIS POMOĆNIH TVARI Pomoćne tvari: natrijev hidrogenfosfat dihidrat, propilenglikol, fenol, kloridna kiselina/natrijev hidroksid (za podešavanje pH) i voda za injekcije.
English: Only doses of 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg or 3.0 mg must be selected with the dose selector.
Croatian: Samo se doze od 0,6 mg, 1,2 mg, 1,8 mg, 2,4 mg ili 3,0 mg smiju odabrati izbornikom doze.
English: Saxenda has no or negligible influence on the ability to drive and use machines.
Croatian: 4.7 Utjecaj na sposobnost upravljanja vozilima i rada sa strojevima Saxenda ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Inflamed gall bladder and gallstones
Croatian: Upala žučnog mjehura i žučni kamenci
English: For body weight, HbA1c, FPG, blood pressure and waist circumference, baseline values are means, changes from baseline at week 56 are estimated means (least-squares) and treatment contrasts at week 56
Croatian: Početne vrijednosti za tjelesnu težinu, HbA1c, FPG, krvni tlak i opseg struka predstavljaju srednje vrijednosti, promjene od početne vrijednosti u 56. tjednu predstavljaju procijenjene srednje vrijednosti (najmanji kvadrati), a kontrasti liječenja u 56. tjednu predstavljaju procijenjene razlike liječenja.
English: Pancreatitis*** Delayed gastric emptying****
Croatian: Odgođeno pražnjenje želuca****
English: Table 6 Trial 3: Changes from baseline in body weight and Apnoea-Hypopnoea Index at week
Croatian: Tablica 6 3. ispitivanje: promjene od početne vrijednosti u tjelesnoj težini i indeksu apneja-hipopneja u 32. tjednu
English: Liraglutide should therefore be used with caution in patients with thyroid disease.
Croatian: Stoga je potreban oprez kod primjene liraglutida u bolesnika s bolešću štitnjače.
English: Cartridge (type 1 glass) with a plunger (bromobutyl) and a laminate rubber sheet (bromobutyl/polyisoprene) contained in a pre-filled multidose disposable pen made of polypropylene, polyacetal, polycarbonate and acrylonitrile butadiene styrene.
Croatian: Uložak (staklo tipa 1) s klipom (brombutil) i pokrovom od laminirane gume (brombutil/poliizopren)
English: FAS: full analysis set.
Croatian: FAS: Potpuni skup podataka za analizu
English: At week 160, while on treatment, 3% treated with Saxenda and 11% treated with placebo were diagnosed with type 2 diabetes mellitus.
Croatian: U 160-tjednu, tijekom liječenja, šećerna bolest tipa 2 dijagnosticirana je u 3% bolesnika liječenih lijekom Saxenda i 11% bolesnika koji su primali placebo.
English: ≥30 kg/m²) or with overweight (BMI ≥27 kg/m²) with dyslipidaemia and/or hypertension were stratified according to pre-diabetes status at screening and BMI at baseline (≥30 kg/m² or
Croatian: (ITM ≥30 kg/m2) ili prekomjerne tjelesne težine (ITM ≥27 kg/m2) s dislipidemijom i/ili hipertenzijom stratificirani su s obzirom na status predijabetesa prilikom probira i početni ITM (≥30 kg/m2 ili <30 kg/m2).
English: and >10% weight loss with liraglutide than with placebo (tables 3-5).
Croatian: U svim ispitivanim populacijama veći je udio bolesnika postigao gubitak tjelesne težine ≥5% i >10% uz primjenu liraglutida nego uz placebo (tablice 3-5).
English: Acute pancreatitis has been observed with the use of GLP-1 receptor agonists.
Croatian: Pankreatitis Akutni pankreatitis zabilježen je kod primjene agonista receptora GLP-1.
English: Please read these instructions carefully before using your Saxenda pre-filled pen.
Croatian: Prije uporabe Saxenda napunjene brizgalice, pažljivo pročitajte ove upute.
English: Dizziness Dysgeusia
Croatian: Omaglica Disgeuzija
English: Cases of inflammation of the pancreas (pancreatitis) have been reported uncommonly in patients using Saxenda.
Croatian: Slučajevi upale gušterače (pankreatitisa) prijavljeni su manje često kod bolesnika liječenih lijekom Saxenda.
English: Saxenda (N=2437) Placebo (N=1225) Saxenda vs. placebo
Croatian: Saxenda (N= 2437) Placebo (N= 1225)
English: No dosage adjustment is required based on age.
Croatian: Nije potrebno prilagođavanje doze prema dobi.
English: How to store Saxenda
Croatian: Kako primjenjivati lijek Saxenda
English: Baseline values are means, changes from baseline at week 56 are estimated means (leastsquares) and treatment contrasts at week 56 are estimated treatment differences.
Croatian: Početne vrijednosti predstavljaju srednje vrijednosti, promjene od početne vrijednosti u 56. tjednu predstavljaju procijenjene srednje vrijednosti (najmanji kvadrati), a kontrasti liječenja u 56. tjednu predstavljaju procijenjene razlike liječenja.
English: Liraglutide did not change the overall exposure of atorvastatin following single dose administration of atorvastatin 40 mg.
Croatian: Liraglutid nije promijenio ukupnu izloženost atorvastatinu nakon primjene jedne doze atorvastatina od
English: Always use the dose counter and the dose pointer to see how many mg you have selected before injecting this medicine.
Croatian: Prije injiciranja ovog lijeka uvijek koristite brojčanik doze i pokazivač doze da biste provjerili koliko ste mg odabrali.
English: At week 0 patients were randomised to receive either Saxenda or placebo.
Croatian: U 0. tjednu randomizacijom je odlučeno koji će bolesnici dobiti lijek Saxenda, a koji placebo.
English: Flatulence Eructation Abdominal distension
Croatian: Bolovi u gornjem dijelu abdomena Flatulencija Podrigivanje Distenzija abdomena
English: Ethnic origin had no clinically relevant effect on the pharmacokinetics of liraglutide based on the results of population pharmacokinetic analysis which included overweight and obese patients of White, Black, Asian and Hispanic/non-Hispanic groups.
Croatian: Prema rezultatima populacijske farmakokinetičke analize koja je obuhvatila bolesnike s prekomjernom tjelesnom težinom i pretile bolesnike bijele, crne, azijske i hispano/ne-hispano skupine, etničko podrijetlo nije imalo klinički značajan učinak na farmakokinetiku liraglutida.
English: Table 4 Trial 1: Changes from baseline in body weight, glycaemia and cardiometabolic parameters at week 160
Croatian: Tablica 4 1. ispitivanje: promjene od početne vrijednosti u tjelesnoj težini, glikemiji i kardiometaboličkim parametrima u 160. tjednu
English: After first use of the pen, store below 30°C or in a refrigerator Keep the pen cap on in order to protect from light
Croatian: Nakon prve primjene brizgalicu čuvati na temperaturi ispod 30°C ili u hladnjaku.
English: 2 Check the flow • Before your first injection with each new pen, check the flow.
Croatian: • Provjerite protok prije prvog injiciranja svaki puta kad uzmete novu brizgalicu.
English: It contains 18 mg of liraglutide and delivers doses of 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg and 3.0 mg.
Croatian: Sadrži 18 mg liraglutida i isporučuje doze od 0,6 mg, 1,2 mg, 1,8 mg, 2,4 mg i 3,0 mg.
English: Hypersensitivity to liraglutide or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivost na liraglutid ili neku od pomoćnih tvari navedenih u dijelu 6.1. 4.4 Posebna upozorenja i mjere opreza pri uporabi
English: Dose injected
Croatian: Injicirana doza
English: Adverse reactions are listed by system organ class and frequency.
Croatian: Nuspojave su razvrstane prema klasifikaciji organskih sustava i učestalosti.
English: Saxenda 6 mg/ml injection liraglutide
Croatian: Saxenda 6 mg/ml injekcija liraglutid s.c. primjena
English: Novo Nordisk A/S Novo Allé 2880 Bagsværd Denmark
Croatian: 2880 Bagsværd
English: In a clinical trial in overweight or obese patients with type 2 diabetes mellitus treated with insulin and liraglutide 3.0 mg/day in combination with diet and exercise and up to 2 OADs, severe hypoglycaemia (requiring third party assistance) was reported by 1.5% of patients treated with liraglutide 3.0 mg/day.
Croatian: U kliničkom ispitivanju na bolesnicima s prekomjernom tjelesnom težinom ili pretilim bolesnicima sa šećernom bolešću tipa 2 koji su liječeni inzulinom i liraglutidom 3,0 mg/dan u kombinaciji s dijetom i tjelovježbom i do dva oralna antidijabetika, tešku hipoglikemiju (koja zahtijeva pomoć druge osobe)
English: Pen scale Pen window
Croatian: Skala na brizgalici Prozorčić na brizgalici
English: • Press and hold down the dose button until the dose counter shows 0.
Croatian: • Pritisnite gumb za doziranje i držite ga pritisnutim sve dok brojčanik doze ne prikaže 0.
English: 0.6 mg once a day
Croatian: 0,6 mg jednom dnevno
English: 1.8 mg once a day
Croatian: 1,8 mg jednom dnevno
English: (pancreatitis).
Croatian: (GLP-1).
English: 3.0 mg once a day
Croatian: 3,0 mg jednom dnevno
English: - if you are allergic to liraglutide or any of the other ingredients of this medicine (listed in section 6).
Croatian: Što morate znati prije nego počnete primjenjivati lijek Saxenda Nemojte primjenjivati lijek Saxenda - ako ste alergični na liraglutid ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Daily doses higher than 3.0 mg are not recommended.
Croatian: Ne preporučuju se dnevne doze više od
English: 2.4 mg once a day
Croatian: 2,4 mg jednom dnevno
English: If you do not check the flow before your first injection with each new pen, you may not get the prescribed dose and the intended effect of Saxenda.
Croatian: Ako ne provjerite protok prije prve injekcije svakom novom brizgalicom,
English: You should see your doctor straight away if you get symptoms such as breathing problems, swelling of face and throat and a fast heartbeat.
Croatian: Odmah odite svom liječniku ako dobijete simptome kao što su problemi s disanjem,
English: Lifestyle intervention in the form of an energy-restricted diet and exercise counselling was background therapy for all patients.
Croatian: Osnovna terapija za sve bolesnike činila je promjena životnog stila u vidu energetski ograničene dijete i savjetovanja o tjelovježbi.
English: Package leaflet: Information for the patient Saxenda 6 mg/ml solution for injection in pre-filled pen liraglutide
Croatian: Uputa o lijeku: Informacije za bolesnika Saxenda 6 mg/ml otopina za injekciju u napunjenoj brizgalici liraglutid
English: Table 3 Trial 1: Changes from baseline in body weight, glycaemia and cardiometabolic parameters at week 56
Croatian: Tablica 3 1. ispitivanje: promjene od početne vrijednosti u tjelesnoj težini, glikemiji i kardiometaboličkim parametrima u 56. tjednu
English: In patients with diabetes mellitus Saxenda must not be used as a substitute for insulin.
Croatian: Hiperglikemija u bolesnika sa šećernom bolešću tipa 2 liječenih inzulinom Saxenda se ne smije primjenjivati u bolesnika sa šećernom bolešću kao zamjena za inzulin.
English: Further important information
Croatian: Ostali izvori informacija
English: Few cases of anaphylactic reactions with symptoms such as hypotension, palpitations, dyspnoea and oedema have been reported with marketed use of liraglutide.
Croatian: Nakon stavljanja liraglutida na tržište, prijavljeno je nekoliko slučajeva anafilaktičkih reakcija sa simptomima kao što su hipotenzija, palpitacije, dispneja i edem.
English: Hypoglycaemia in patients with type 2 diabetes mellitus treated with insulin
Croatian: Hipoglikemija u bolesnika sa šećernom bolešću tipa 2 liječenih inzulinom
English: Some severe allergic reactions (anaphylaxis) have been reported rarely in patients using Saxenda.
Croatian: Kod bolesnika liječenih lijekom Saxenda rijetko su prijavljene određene teške alergijske reakcije (anafilaksa).
English: Always make sure that a drop appears at the needle tip before you use a new pen for the first time.
Croatian: Prije nego prvi put upotrijebite novu brizgalicu uvijek provjerite da se kapljica pojavila na vrhu igle.
English: Week 5 onwards
Croatian: Od 5. tjedna nadalje
English: Mean change at week 32, % (95% CI) Mean change at week 32, kg (95% CI)
Croatian: Srednja promjena u 32. tjednu, kg (95% CI)
English: • Inflamed gall bladder
Croatian: • Žučni kamenci
English: Liraglutide significantly reduced the rate of major adverse cardiovascular events (primary endpoint events, MACE) vs. placebo (3.41 vs. 3.90 per 100 patient years of observation in the liraglutide and placebo groups, respectively) with a risk reduction of 13%, HR 0.87, [0.78, 0.97] [95% CI]) (p=0.005) (see figure 4).
Croatian: Liraglutid je značajno smanjio stopu velikih kardiovaskularnih štetnih događaja (događaji primarne mjere ishoda, MACE) naspram placeba (3,41 u skupini za liraglutid naspram 3,90 za placebo na 100
English: Start by checking your pen to make sure that it contains Saxenda 6 mg/ml,
Croatian: Započnite tako što ćete provjeriti brizgalicu kako biste bili sigurni da sadrži lijek Saxenda 6 mg/ml, a zatim pogledajte ilustracije u nastavku kako biste se upoznali s različitim dijelovima brizgalice i s iglom.
English: Hypoglycaemia in patients with type 2 diabetes mellitus
Croatian: Hipoglikemija u bolesnika sa šećernom bolešću tipa 2
English: • However, if more than 12 hours have passed since you should have used Saxenda, skip the missed dose and inject your next dose the following day at the usual time.
Croatian: preskočite propuštenu dozu i injicirajte sljedeću dozu narednog dana u uobičajeno vrijeme.
English: The estimated time to onset of type 2 diabetes mellitus for patients treated with liraglutide 3.0 mg was 2.7 times longer (with a 95% confidence interval of [1.9, 3.9]), and the hazard ratio for risk of developing type 2 diabetes mellitus was 0.2 for liraglutide versus placebo.
Croatian: Procijenjeno vrijeme do nastupa šećerne bolesti tipa 2 za bolesnike liječene liraglutidom u dozi od 3,0 mg bilo je 2,7 puta duže (s intervalom pouzdanosti od
English: 1.2 mg once a day
Croatian: 1,2 mg jednom dnevno
English: Hypoglycaemia in patients without type 2 diabetes mellitus
Croatian: Opis izdvojenih nuspojava: Hipoglikemija u bolesnika bez šećerne bolesti tipa 2
English: Mean change at week 160, % (95% CI) Mean change at week 160, kg (95% CI)
Croatian: Srednja promjena u 160. tjednu, kg (95% CI)
English: (such as exenatide or lixisenatide).
Croatian: GLP-1 (kao što je eksenatid ili liksisenatid).
English: Contents of the pack and other information
Croatian: Kako čuvati lijek Saxenda Sadržaj pakiranja i druge informacije
English: * p<0.05.
Croatian: HR: 0.87
English: Instructions on how to use Saxenda 6 mg/ml solution for injection in prefilled pen
Croatian: Upute za uporabu lijeka Saxenda 6 mg/ml otopine za injekciju u napunjenoj brizgalici
English: Saxenda (N=207) Placebo (N=206) Saxenda vs. placebo
Croatian: Tablica 7 4. ispitivanje: promjene od početne vrijednosti u tjelesnoj težini u 56. tjednu Saxenda (N= 207) Placebo (N= 206) Saxenda naspram placeba
English: 1 ml contains 6 mg of liraglutide.
Croatian: NAVOĐENJE DJELATNE TVARI 1 ml sadrži 6 mg liraglutida.
English: Saxenda 6 mg/ml solution for injection in pre-filled pen liraglutide
Croatian: Saxenda 6 mg/ml otopina za injekciju u napunjenoj brizgalici liraglutid
English: Each pen contains 3 ml solution and is able to deliver doses of 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg and 3.0 mg.
Croatian: Jedna brizgalica sadrži 3 ml otopine i može primijeniti doze od 0,6 mg, 1,2 mg, 1,8 mg, 2,4 mg i 3,0 mg.
English: Mean change at week 56, % (95% CI) Mean change at week 56, kg (95% CI)
Croatian: Početna vrijednost, kg (SD) Srednja promjena u 56. tjednu, % (95% CI) -5,9 Srednja promjena u 56. tjednu, kg (95% CI)
English: Age had no clinically relevant effect on the pharmacokinetics of liraglutide based on the results from a population pharmacokinetic analysis of data from overweight and obese patients (18 to 82 years).
Croatian: Prema rezultatima analize populacijskih farmakokinetičkih podataka pretilih i bolesnika s prekomjernom tjelesnom težinom (18 do 82 godina), dob nije imala klinički značajan učinak na farmakokinetiku liraglutida.
English: • Dizziness
Croatian: • povraćanje
English: Digoxin median tmax was delayed from 1 h to 1.5 h. No dose adjustment of digoxin is required based on these results.
Croatian: Medijan tmax digoksina bio je odgođen sa 1 h na 1,5 h.
English: Injection site reactions Asthenia Fatigue
Croatian: Reakcije na mjestu injiciranja Astenija
English: For patients who experience a clinically relevant sustained increase in resting heart rate, treatment with liraglutide should be discontinued.
Croatian: Liječenje liraglutidom potrebno je prekinuti u bolesnika kod kojih je prisutan klinički značajan trajan porast srčane frekvencije tijekom mirovanja.
English: Hold the dose button down until the dose counter shows 0.
Croatian: Pritisnite gumb za doziranje i držite ga pritisnutim sve dok brojčanik doze ne pokaže 0.
English: Proportion of patients losing >10% body weight at week 160, % (95% CI)
Croatian: Udio bolesnika koji su izgubili >10% tjelesne težine u 160. tjednu, % (95% CI)
English: Superior weight loss was achieved with liraglutide compared to placebo in obese/overweight patients in all groups studied.
Croatian: U pretilih/bolesnika s prekomjernom tjelesnom težinom, u svim ispitivanim skupinama, postignut je superioran gubitak tjelesne težine uz primjenu liraglutida u usporedbi s primjenom placeba.
English: Pancreatitis
Croatian: Tahikardija
English: • Trial 4 (SCALE Maintenance - 1923): A 56-week trial assessing body weight maintenance and weight loss in 422 randomised (305 completers) obese and overweight patients with hypertension or dyslipidaemia after a preceding weight loss of ≥5% induced by a low-calorie diet.
Croatian: • 4. ispitivanje (SCALE Maintenance - 1923): 56-tjedno ispitivanje koje je procjenjivalo održavanje i gubitak tjelesne težine kod 422 randomizirana (od kojih je 305 dovršilo ispitivanje)
English: Liraglutide lowered ethinylestradiol and levonorgestrel Cmax by 12% and 13%, respectively, following administration of a single dose of an oral contraceptive product.
Croatian: Nakon primjene jedne doze oralnog kontraceptiva liraglutid je smanjio Cmax etinilestradiola za 12%, a levonorgestrela za 13%.
English: 2.4 mg left
Croatian: 2,4 mg
English: Proportion of patients losing ≥5% body weight at week 56, % (95% CI)
Croatian: Udio bolesnika koji su izgubili ≥5% tjelesne težine u 56. tjednu, % (95% CI)
English: Proportion of patients losing >10% body weight at week 56, % (95% CI)
Croatian: Udio bolesnika koji su izgubili >10% tjelesne težine u 56. tjednu, % (95% CI)
English: Gastro-oesophageal reflux disease Abdominal pain upper
Croatian: Gastroezofagealna refluksna bolest