FrancophonIA/ELRC3.0 huggingface dataset:
English: In these studies, clinically and statistically significant improvement was observed in the abatacept group as compared with the placebo group in all 8 domains of the SF-36 (4 physical domains: physical function, role physical, bodily pain, general health; and 4 mental domains: vitality, social function, role emotional, mental health), as well as the Physical Component Summary (PCS) and the Mental Component Summary (MCS).
Croatian: U tim je ispitivanjima zabilježeno klinički i statistički značajno poboljšanje u skupini liječenoj abataceptom, u odnosu na skupinu koja je primala placebo, u svih 8 domena upitnika SF-36 (4 domene fizičkog zdravlja: fizičko funkcioniranje, ograničenje zbog fizičkih teškoća, tjelesni bolovi i percepcija općeg zdravlja te 4 domene psihičkog zdravlja: vitalnost, socijalno funkcioniranje, ograničenje zbog emocionalnih teškoća i psihičko zdravlje), kao i poboljšanje profila fizičkog zdravlja (engl.
English: Medicinal products which affect the immune system, including ORENCIA, may affect host defences against infections and malignancies, and affect vaccination responses.
Croatian: Lijekovi koji djeluju na imunološki sustav, uključujući lijek ORENCIA, mogu utjecati na obranu domaćina protiv infekcija i zloćudnih bolesti kao i na odgovor organizma na cijepljenje.
English: Remove the ClickJect Pre-filled Pen from the injection site by lifting it straight up.
Croatian: Uklonite brizgalicu ClickJect s mjesta injekcije tako što ćete je podignuti ravno prema gore.
English: If this happens, contact immediately your doctor who will monitor you for any signs or symptoms of side effects, and treat these symptoms if necessary.
Croatian: Ako se to dogodi, odmah se javite svom liječniku, koji će Vas nadzirati kako bi uočio bilo kakve znakove ili simptome nuspojava te po potrebi liječiti te simptome.
English: Excipient with known effect sodium: 0.375 mmol (8.625 mg) per vial
Croatian: Pomoćna tvar s poznatim učinkom natrij: 0,375 mmol (8,625 mg) po bočici
English: A. Choose an area of your body for the injection (injection site) You can use: o the front of your thigh o your abdomen, except for the 5 cm area around the navel (Figure 3).
Croatian: Odaberite područje na tijelu u koje ćete dati injekciju (mjesto injekcije) Možete odabrati: o prednji dio bedra o trbuh, osim područja od 5 cm oko pupka (Slika 3).
English: Two patients (2/117, 1.7%) using the SC prefilled pen experienced local injection site reactions.
Croatian: Dva bolesnika (2/117; 1,7%) liječena s.c. formulacijom u napunjenoj brizgalici imala su lokalne reakcije na mjestu injekcije.
English: While TNF-inhibitors did not influence abatacept clearance, in placebo-controlled clinical trials, patients receiving concomitant treatment with abatacept and TNF-inhibitors experienced more infections and serious infections than patients treated with only TNF-inhibitors.
Croatian: Iako TNF-inhibitori nisu utjecali na klirens abatacepta, u placebom kontroliranim kliničkim ispitivanjima bolesnici koji su istodobno liječeni abataceptom i TNF-inhibitorima imali su više infekcija i ozbiljnih infekcija nego bolesnici liječeni samo TNF-inhibitorima.
English: The primary endpoint for both PsA-I and PsA-II was the proportion of patients achieving ACR 20 response at Week 24 (day 169).
Croatian: PsA-II bio je udio bolesnika koji su postigli odgovor ACR 20 u 24. tjednu (169. dana).
English: The efficacy response over time in this study appeared consistent with studies that included an intravenous loading dose, however, the effect of no intravenous load on the onset of efficacy has not been formally studied.
Croatian: Odgovor u smislu djelotvornosti tijekom vremena u ovom se ispitivanju činio sukladnim onomu u ispitivanjima koja su uključivala intravensku udarnu dozu, no učinak intravenske udarne doze na početak djelotvornosti nije formalno ispitivan.
English: However, if you are feeling tired or unwell after receiving ORENCIA, you should not drive, cycle or operate any machinery.
Croatian: Međutim, ako se osjećate umorno ili loše nakon što ste primili lijek ORENCIA, ne smijete upravljati vozilima, voziti bicikl niti rukovati bilo kakvim strojevima.
English: There is a theoretical concern that treatment with abatacept might increase the risk for autoimmune processes in adults and children, for example deterioration of multiple sclerosis.
Croatian: Teoretski se pri liječenju abataceptom može povećati rizik od autoimunih procesa u odraslih i djece, primjerice pogoršanje multiple skleroze.
English: Subjects continued taking their current dose of MTX from the day of randomisation.
Croatian: Ispitanici su od dana randomizacije nastavili uzimati MTX u dotadašnjoj dozi.
English: Talk to your doctor, pharmacist or nurse: if you experience allergic reactions such as chest tightness, wheezing, severe dizziness or lightheadedness, swelling or skin rash tell your doctor immediately.
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri: ako dobijete alergijske reakcije kao što su stezanje u prsima, piskanje pri disanju, teška omaglica ili ošamućenost, oticanje ili osip kože, odmah o tome obavijestite svog liječnika.
English: SC bioavailability (F) increased by 28% and the absorption rate constant (KA) was higher in pJIA patients than RA patients.
Croatian: Bioraspoloživost (F) nakon supkutane primjene povećala se za 28%, a konstanta brzine apsorpcije (KA) bila je veća u bolesnika s pJIA-om nego u onih s reumatoidnim artritisom.
English: The type of serious infections was similar between the abatacept and placebo treatment groups (see section 4.4).
Croatian: Vrsta ozbiljnih infekcija bila je slična u skupini liječenoj abataceptom i onoj koja je primala placebo (vidjeti dio 4.4).
English: The safety and efficacy of intravenous abatacept were assessed in a three-part study.
Croatian: Sigurnost i djelotvornost intravenski primijenjenog abatacepta ispitane su u trodijelnom ispitivanju.
English: If any serious allergic or anaphylactic reaction occurs, intravenous or subcutaneous ORENCIA therapy should be discontinued immediately and appropriate therapy initiated, and the use of ORENCIA should be permanently discontinued (see section 4.8).
Croatian: U slučaju ozbiljne alergijske ili anafilaktičke reakcije, intravenska ili supkutana primjena lijeka ORENCIA mora se odmah prekinuti i započeti odgovarajuća terapija, a liječenje lijekom ORENCIA mora se trajno obustaviti (vidjeti dio 4.8).
English: In Period A all patients received 10 mg/kg of abatacept on days 1, 15, 29, 57 and 85 and were assessed on day 113.
Croatian: Razdoblju A, svi su bolesnici primili abatacept u dozi od 10 mg/kg 1., 15., 29., 57. i 85. dana, a ocijenjeni su 113. dana.
English: ORENCIA is used to: slow down the damage to your joints improve your physical function
Croatian: ORENCIA se primjenjuje kako bi se: - usporilo oštećenje Vaših zglobova - poboljšale Vaše fizičke funkcije.
English: Anti-rheumatic therapies have been associated with hepatitis B reactivation.
Croatian: Antireumatska terapija povezuju se s reaktivacijom hepatitisa B.
English: To be administered as a 30-minute intravenous infusion at the dose specified in Table 1.
Croatian: Lijek se primjenjuje u obliku 30-minutne intravenske infuzije u dozi navedenoj u Tablici
English: You will be trained by your doctor or nurse on how to self-inject ORENCIA using the pre-filled syringe.
Croatian: Vaš liječnik ili medicinska sestra će Vas naučiti kako ćete si sami dati injekciju lijeka ORENCIA pomoću napunjene štrcaljke.
English: Treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis.
Croatian: Liječenje mora započeti i nadzirati liječnik specijalist s iskustvom u dijagnosticiranju i liječenju reumatoidnog artritisa.
English: The side effects experienced in children and adolescents with polyarticular juvenile idiopathic arthritis are similar to those experienced in adults as described above with the following differences:
Croatian: Nuspojave koje su doživjela djeca i adolescenti s poliartikularnim juvenilnim idiopatskim artritisom slične su onima navedenima za odrasle osobe, uz sljedeće razlike:
English: After pneumococcal vaccination, 62 of 112 abatacept-treated patients were able to mount an adequate immune response of at least a 2-fold increase in antibody titers to pneumococcal polysaccharide vaccine.
Croatian: Nakon cijepljenja protiv pneumokoka, 62 od 112 bolesnika liječenih abataceptom uspjelo je postići odgovarajući imuni odgovor od najmanje dvostrukog povećanja titra protutijela na polisaharidno pneumokokno cjepivo.
English: Keep track of your next dose.
Croatian: Vodite računa o tome kada trebate dobiti sljedeću dozu.
English: Avoid any areas with scars or stretch marks.
Croatian: Izbjegavajte područja s ožiljcima i strijama.
English: Information on the relative safety in a clinical trial versus infliximab is summarised in section 5.1.
Croatian: Podaci o relativnoj sigurnosti u kliničkom ispitivanju u odnosu na infliksimab sažeto su prikazani u dijelu 5.1.
English: At a dose of 200 mg/kg, representing 11-fold a human exposure at 10 mg/kg based on AUC, limited changes in immune function (a 9-fold increase in the mean T-cell-dependent antibody response in female pups and inflammation of the thyroid of 1 female pup out of 10 male and 10 female pups evaluated at this dose) were observed.
Croatian: Pri dozi od 200 mg/kg, što na temelju AUC-a predstavlja 11 puta veću razinu izloženosti od one u ljudi pri dozi od 10 mg/kg, opažene su ograničene promjene u funkcioniranju imunološkog sustava (9 puta povećanje prosječnog o T-stanicama ovisnog odgovora antitijela u ženske mladunčadi i upala štitnjače u jednog mladunca ženskog spola između 10 muških i 10 ženskih mladunaca ispitanih pri toj dozi).
English: If you miss receiving ORENCIA when you are supposed to, ask your doctor when to schedule your next dose.
Croatian: Ako propustite primiti lijek ORENCIA u predviđeno vrijeme, upitajte svog liječnika za kada treba planirati sljedeću dozu.
English: The most common side effects with ORENCIA are infections of the upper airway (including infections of the nose and throat), headache and nausea, as listed below.
Croatian: Najčešće nuspojave kod primjene lijeka ORENCIA su infekcije gornjih dišnih putova (uključujući infekcije nosa i grla), glavobolja i mučnina, kako je navedeno u nastavku.
English: d Reduction in HAQ-DI of ≥ 0.3 units from baseline.
Croatian: d Smanjenje početne vrijednosti HAQ-DI indeksa za ≥ 0,3 jedinice.
English: The presence of antibodies was not associated with adverse reactions, or with changes in efficacy or serum abatacept concentrations, in either cohort.
Croatian: Prisutnost antitijela nije bila povezana s nuspojavama ni infuzijskim reakcijama, kao niti s promjenama djelotvornosti ili serumskih koncentracija abatacepta, u bilo kojoj kohorti.
English: For children and adolescents aged 6 to 17 years with polyarticular juvenile idiopathic arthritis who weigh less than 75 kg, the recommended dose of intravenous abatacept is 10 mg/kg.
Croatian: Za djecu i adolescente u dobi od 6 do 17 godina s poliartikularnim juvenilnim idiopatskim artritisom koji imaju manje od 75 kg, preporučena doza abatacepta za primjenu u venu je 10 mg/kg.
English: Studies I, II, III, IV, V, VI, SC-I, SC-II, and SC-III evaluated 339, 638, 389, 1441, 431, 509, 1371, 646, and 351 adult patients, respectively.
Croatian: U ispitivanjima I, II, III, IV, V, VI, SC-I, SC-II i SC-III ocijenjeno je 339, 638, 389, 1441, 431, 509, 1371, 646 odnosno 351 odraslih bolesnika.
English: Uncommon (may affect up to 1 in 100 people): blood in urine ear infection
Croatian: Manje često (mogu se javiti u do 1 na 100 osoba): krv u mokraći infekcija uha
English: All injection site reactions were described as mild to moderate (hematoma, pruritus, or erythema) and generally did not necessitate drug discontinuation.
Croatian: Sve su reakcije na mjestu injekcije opisane kao blage do umjerene (hematom, svrbež ili eritem) te u pravilu nisu zahtijevale prekid primjene lijeka.
English: ORENCIA can also be used with methotrexate to treat highly active and progressive rheumatoid arthritis without previous methotrexate treatment.
Croatian: ORENCIA se zajedno s metotreksatom može koristiti i za liječenje izrazito aktivnog i progresivnog reumatoidnog artritisa koji prethodno nije bio liječen metotreksatom.
English: Studies I, II, III, IV, V, VI, SC-II, and SC-III evaluated 339, 638, 389, 1441, 431, 509, 646, and 351 adult patients, respectively.
Croatian: U ispitivanjima I, II, III, IV, V, VI, SC-II i SC-III ocijenjeno je 339, 638, 389, 1441, 431, 509, 646 odnosno 351 odraslih bolesnika.
English: Administration of live vaccines to infants exposed to abatacept in utero is not recommended for 14 weeks following the mother's last exposure to abatacept during pregnancy.
Croatian: Ne preporučuje se davati živa cjepiva novorođenčadi izloženoj abataceptu in utero tijekom 14 tjedana nakon majčina posljednjeg izlaganja abataceptu tijekom trudnoće.
English: Studies indicate that naive T lymphocyte responses are more affected by abatacept than memory T lymphocyte responses.
Croatian: Ispitivanja pokazuju da abatacept više utječe na odgovor naivnih T-limfocita nego na odgovor memorijskih T-limfocita.
English: Your doctor may recommend a different method for monitoring your blood glucose levels.
Croatian: Liječnik će Vam možda preporučiti neku drugu metodu za mjerenje šećera u krvi.
English: For ITT; n=736, 721 for subcutaneous (SC) and intravenous (IV) abatacept,
Croatian: Za ITT; n=736 za abatacept za supkutanu (s.c.)
English: No studies were conducted to examine the effects of either renal or hepatic impairment on the pharmacokinetics of abatacept.
Croatian: Nisu provedena ispitivanja učinaka oštećenja bubrežne ili jetrene funkcije na farmakokinetiku abatacepta.
English: Look closely to make sure that the amount of liquid in the pre-filled syringe is at or just above the fill line for your prescribed dose:
Croatian: Dobro je pogledajte kako biste se uvjerili da količina tekućine u napunjenoj štrcaljki doseže ili neznatno premašuje liniju punjenja koja odgovara propisanoj dozi.
English: Upon reinitiating therapy, there were no injection reactions and no other safety concerns in patients who were withdrawn from subcutaneous therapy for up to 3 months relative to those who remained on subcutaneous therapy, whether therapy was reintroduced with or without an intravenous loading dose.
Croatian: Nakon ponovnog uvođenja terapije nisu zabilježene reakcije na injekciju niti drugi problem vezani uz sigurnost primjene u bolesnika koji su prekinuli supkutano liječenje do najdulje 3 mjeseca, bez obzira na to je li liječenje ponovno uvedeno s primjenom intravenske udarne doze, ili bez nje.
English: In rats, abatacept had no undesirable effects on male or female fertility.
Croatian: U štakora abatacept nije izazvao štetne učinke na plodnost mužjaka ni ženki.
English: In patients assessed for anti-abatacept antibodies after discontinuation of abatacept (> 42 days after last dose), 103 of 1,888 (5.5%) were seropositive.
Croatian: Među bolesnicima koji su testirani na antitijela na abatacept nakon prekida liječenja abataceptom (> 42 dana nakon posljednje doze), seropozitivno je bilo 103 od 1888 ispitanih (5,5%).
English: There is a theoretical concern that treatment with abatacept might increase the risk for autoimmune processes in adults, for example deterioration of multiple sclerosis.
Croatian: Teoretski se pri liječenju abataceptom može povećati rizik od autoimunih procesa u odraslih, primjerice pogoršanje multiple skleroze.
English: In the 6 to 17 year age cohort 132 (76.3%) patients completed 2 years.
Croatian: U kohorti ispitanika u dobi od 6 do 17 godina, 132 (76.3%) bolesnika dovršila su 2 godine liječenja.
English: Children weighing 75 kg or more should be administered ORENCIA powder for concentrate for solution for infusion following the adult dosing regimen.
Croatian: U djece tjelesne težine 75 kg ili više treba primjenjivati ORENCIA prašak za koncentrat za otopinu za infuziju prema režimu doziranja za odrasle.
English: Hold the syringe by its body in one hand, and pull the needle cover straight off with your other hand (Figure 4).
Croatian: Jednom rukom držite tijelo štrcaljke, a drugom ravno povucite poklopac igle (Slika 4).
English: The efficacy and safety of intravenous abatacept were assessed in randomised, double-blind, placebocontrolled clinical trials in adult patients with active rheumatoid arthritis diagnosed according to American College of Rheumatology (ACR) criteria.
Croatian: Djelotvornost i sigurnost intravenski primijenjenog abatacepta ispitane su u randomiziranim, dvostruko slijepim, placebom kontroliranim kliničkim ispitivanjima u odraslih bolesnika s aktivnim reumatoidnim artritisom dijagnosticiranim prema kriterijima Američkog društva za reumatologiju (engl.American College of Rheumatology, ACR).
English: The safety and efficacy of ORENCIA in children below 2 years of age have not been established.
Croatian: Sigurnost i djelotvornost lijeka ORENCIA u djece mlađe od 2 godine nisu ustanovljene.
English: The presence of antibodies was not associated with adverse reactions or infusion reactions, or with changes in efficacy or serum abatacept concentrations.
Croatian: Prisutnost antitijela nije bila povezana s nuspojavama ni infuzijskim reakcijama, kao niti s promjenama djelotvornosti ili serumskih koncentracija abatacepta.
English: You may notice a drop of fluid leaving the needle.
Croatian: Možda ćete primijetiti da iz igle izlazi kapljica tekućine.
English: One serious adverse reaction of infection (limb abscess) was reported in the 2 to 5 year age cohort during the 20-month extension period of the pJIA SC study.
Croatian: Jedna ozbiljna nuspojava infekcije (apsces udova) prijavljena je u kohorti od 2 do 5 godina starosti tijekom 20-mjesečnog razdoblja nastavka ispitivanja pJIA SC.
English: Inspect the syringe for obvious flaws, but don't remove the needle cover.
Croatian: Pregledajte je li štrcaljka oštećena, ali nemojte skidati poklopac za iglu.
English: It is recommended that patients with juvenile idiopathic arthritis be brought up to date with all immunizations in agreement with current immunization guidelines prior to initiating ORENCIA therapy (see section 4.5).
Croatian: Preporučuje se da bolesnici s juvenilnim idiopatskim artritisom obave sva cijepljenja u skladu s važećim programom cijepljenja prije početka terapije lijekom ORENCIA (vidjeti dio 4.5).
English: Physicians should exercise caution when considering the use of ORENCIA in patients with a history of recurrent infections or underlying conditions which may predispose them to infections.
Croatian: Liječnici moraju s oprezom razmatrati primjenu lijeka ORENCIA u bolesnika s anamnezom rekurentnih infekcija ili podležećim stanjima koja mogu predstavljati predispoziciju za infekcije.
English: Paediatric pJIA population
Croatian: Pedijatrijska pJIA populacija
English: In rats, abatacept had no undesirable effects on male or female fertility (see section 5.3).
Croatian: Kod štakora abatacept nije izazvao štetne učinke na plodnost mužjaka ni ženki (vidjeti dio 5.3).
English: The total content (1 mL) of the pre-filled pen should be administered as a subcutaneous injection only.
Croatian: Cjelokupan sadržaj (1 ml) napunjene brizgalice treba primijeniti isključivo supkutanom injekcijom.
English: Abatacept therapy did not lead to increased formation of autoantibodies, i.e., antinuclear and antidsDNA antibodies, compared with placebo.
Croatian: Terapija abataceptom nije dovela do povećanog stvaranja autoantitijela, tj. antinuklearnih i anti-dsDNK antitijela, u usporedbi s placebom.
English: The efficacy and safety of abatacept were assessed in two randomised, double-blind, placebocontrolled trials (studies PsA-I and PsA-II) in adult patients, age 18 years and older.
Croatian: Djelotvornost i sigurnost abatacepta ocjenjivale su se u dva randomizirana, dvostruko slijepa, placebom kontrolirana ispitivanja (PsA-I i PsA-II) provedena u odraslih bolesnika u dobi od 18 ili više godina.
English: MARKETING AUTHORISATION NUMBERS EU/1/07/389/011-012
Croatian: BROJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/07/389/011-012
English: Blue Indicator
Croatian: Rok valjanosti plavi indikator
English: If the expiry date has passed, do not use the syringes.
Croatian: Ako je rok valjanosti istekao, nemojte upotrijebiti štrcaljke.
English: Structural joint damage was assessed radiographically over a two-year period in studies II, VI, and SC-II.
Croatian: Strukturno oštećenje zglobova ocjenjivano je radiografski tijekom dvogodišnjeg razdoblja u ispitivanjima II, VI i SC-II.
English: ORENCIA selectively modulates the activation of T cells involved in the immune system's inflammatory response.
Croatian: ORENCIA selektivno modulira aktiviranje T-stanica uključenih u upalni odgovor imunološkog sustava.
English: The entire, fully diluted ORENCIA solution should be administered over a period of 30 minutes and must be administered with an infusion set and a sterile, non-pyrogenic, low-protein-binding filter (pore size of 0.2 to 1.2 μm).
Croatian: Cjelokupnu, potpuno razrijeđenu otopinu lijeka ORENCIA treba primijeniti tijekom razdoblja od 30 minuta, a mora se primjenjivati pomoću infuzijskog seta sa sterilnim, nepirogenim filtrom koji minimalno veže proteine (veličina pora od 0,2 do 1,2 μm).
English: Do not touch the injection site again before giving the injection.
Croatian: Nemojte ponovno dodirivati mjesto injekcije prije injiciranja.
English: Period A was a 4-month open-label lead-in designed to induce an ACR Pedi 30 response.
Croatian: Razdoblje A predstavljalo je 4-mjesečno otvoreno uvodno razdoblje, ustrojeno tako da se potakne odgovor Ped ACR30.
English: Always keep your Sharps container out of reach of children and animals.
Croatian: Uvijek čuvajte posudu za odlaganje oštrih predmeta izvan dohvata djece i životinja.
English: Abatacept has been shown to be present in rat milk.
Croatian: Abatacept je pronađen u mlijeku štakorica.
English: Proportion of patients with ACR responses at week 24 in studies PsA-I and PsA-II
Croatian: Udio bolesnika s ACR odgovorima u 24. tjednu ispitivanja PsA-I i PsA-II
English: The GDH-PQQ based glucose monitoring systems may react with the maltose present in ORENCIA, resulting in falsely elevated blood glucose readings on the day of infusion.
Croatian: Sustavi za mjerenje šećera u krvi koji se temelje na metodi GDH-PQQ mogu reagirati s maltozom u lijeku ORENCIA, što za posljedicu ima lažno očitanje povećanih vrijednosti glukoze u krvi na dan infuzije.
English: The most frequently reported autoimmune-related disorders other than the indication being studied during the cumulative period were psoriasis, rheumatoid nodule, and Sjogren's syndrome.
Croatian: Najčešće prijavljeni autoimuni poremećaji (osim indikacije za koju se lijek ispitivao) tijekom kumulativnog razdoblja bili su psorijaza, reumatoidni noduli i Sjögrenov sindrom.
English: When the intravenous loading dose was not administered, a mean trough concentration of 12.6 mcg/mL was achieved after 2 weeks of dosing.
Croatian: Kada nije primijenjena intravenska udarna doza, prosječna najniža koncentracija od 12,6 µg/ml postignuta je nakon 2 tjedna primjene.
English: During the first 4-month treatment period of intravenous and subcutaneous abatacept in 409 patients with pJIA, the most common adverse reactions were nasopharyngitis (3.7% patients) and upper respiratory tract infection (2.9% patients).
Croatian: Tijekom prvog 4-mjesečnog razdoblja intravenskog i supkutanog liječenja abataceptom u 409 bolesnika s pJIA-om, najčešće nuspojave bile su nazofaringitis (3,7% bolesnika) i infekcija gornjih dišnih putova (2,9% bolesnika).
English: ORENCIA is used to treat moderate to severe active rheumatoid arthritis when you do not respond well enough to treatment with other disease-modifying medicines or with another group of medicines called 'tumour necrosis factor (TNF) blockers'.
Croatian: ORENCIA se primjenjuje za liječenje umjerenog do teškog oblika aktivnog reumatoidnog artritisa kada niste dovoljno dobro odgovorili na liječenje drugim lijekovima koji mijenjaju tijek bolesti ili lijekovima iz druge skupine pod nazivom "blokatori faktora nekroze tumora" (TNF-blokatori).