FrancophonIA/ELRC3.0 huggingface dataset:
English: FAP patients carrying an ileorectal anastomosis or ileo pouch-anal anastomosis can develop anastomotic ulcerations.
Slovenian: Pri bolnikih s FAP, ki imajo ileorektalno anastomozo ali analno anastomozo ilealnega žepa, se lahko pojavijo anastomozni ulkusi.
English: Celecoxib does not affect the pharmacokinetics of tolbutamide (CYP2C9 substrate), or glibenclamide
Slovenian: Celekoksib ne vpliva klinično pomembno na farmakokinetiko tolbutamida (substrat CYP2C9) ali
English: When dosed at 200 mg per day the corresponding values in patients with moderate hepatic impairment were 41% and 146% respectively.
Slovenian: Ob odmerku 200 mg na dan je bila Cmax pri bolnikih z zmerno jetrno okvaro 41 % in AUC 146 %.
English: However, adequate monitoring for methotrexate-related toxicity should be considered when combining these two
Slovenian: Vendar je med sočasno uporabo teh dveh zdravil priporočljivo ustrezno spremljati toksične učinke metotreksata.
English: Celecoxib, as with other medicinal products inhibiting prostaglandin synthesis, may cause uterine inertia and premature closure of the ductus arteriosus during the last trimester.
Slovenian: Tako kot druga zdravila, ki zavirajo sintezo prostaglandinov, lahko tudi celekoksib v zadnjem trimesečju povzroči inertnost maternice in prezgodnje zaprtje arterioznega duktusa.
English: Patients with severe hepatic impairment (serum albumin <25 g/l) have not been studied and celecoxib is contraindicated in this patient group.
Slovenian: Študij pri bolnikih s hudo jetrno okvaro (albumin v serumu < 25 g/l) niso izvedli, zato je celekoksib pri teh bolnikih kontraindiciran.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Tega zdravila ne smejo jemati bolniki z redkimi prirojenimi motnjami, kot na primer intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorbcijo glukoze in galaktoze.
English: Data from a third long-term study, ADAPT (The Alzheimer's Disease Anti-inflammatory Prevention Trial), did not show a significantly increased cardiovascular risk with celecoxib 200mg BID compared to placebo.
Slovenian: Podatki tretje dolgoročne študije, ADAPT (The Alzheimer's Disease Anti-inflammatory Prevention Trial), med uporabo celekoksiba 200 mg dvakrat na dan niso pokazali statistično pomembno večjega srčnožilnega tveganja kot s placebom.
English: Celecoxib is mainly eliminated by metabolism.
Slovenian: Celekoksib se izloča predvsem s presnovo.
English: The concomitant use of celecoxib and a non-aspirin NSAID should be avoided.
Slovenian: Celekoksiba ne uporabljajte sočasno z ne-aspirinskimi nesteroidnimi protivnetnimi zdravili.
English: In three separate single dose studies, involving a total of 5 subjects genotyped as CYP2C9*3/*3, single-dose AUC 0-24 increased by approximately 3-fold compared to normal metabolizers.
Slovenian: V treh ločenih študijah posamičnih odmerkov, ki so zajele 5 preiskovancev, genotipiziranih kot CYP2C9*3/*3, je bila AUC 0-24 po posamičnem odmerku približno 3-krat tolikšna kot pri bolnikih, ki normalno presnavljajo.
English: During celecoxib treatment, the mean plasma concentrations of the CYP2D6 substrate dextromethorphan were increased by 136%.
Slovenian: Povprečna plazemska koncentracija dekstrometorfana, substrata CYP2D6, se je med zdravljenjem s celekoksibom zvečala za 136 %.
English: Pharmacological activity resides in the parent substance.
Slovenian: Farmakološko aktivna je osnovna spojina.
English: The recommended oral dose is one 400 mg capsule twice per day, taken with food (see section 5.2).
Slovenian: Priporočeni peroralni odmerek je ena 400 mg kapsula dvakrat na dan zaužita s hrano (glejte poglavje
English: The incidence of myocardial infarction was 1.1% (8/717 patients) with celecoxib 200 mg twice daily and 1.2% (13/1070 patients) with placebo.
Slovenian: Incidenca miokardnega infarkta je bila z 200 mg celekoksiba dvakrat na dan 1,1 % (8/717 bolnikov) in s placebom 1,2 % (13/1070) bolnikov.
English: Cumulative rates for this composite endpoint over 3 years were 3.0% (20/671 subjects) and 2.5% (17/685 subjects), respectively, compared to 0.9% (6/679 subjects) for placebo.
Slovenian: Kumulativna deleža za ta sestavljeni opazovani dogodek v 3-letnem obdobju sta bila 3,0 % (20/671 preiskovancev) in 2,5 % (17/685 preiskovancev) v primerjavi z 0,9 % (6/679 preiskovancev) pri placebu.
English: Celecoxib inhibits tumour formation in preclinical models of colon cancer, which overexpress COX-2, whether induced by chemical (rat AOM model) or genetic (MIN mouse model) mutation.
Slovenian: V predkliničnih modelih karcinoma na kolonu s prekomerno izraženo COX-2 celekoksib zavira nastanek tumorjev, izzvanih s kemično (model podgan AOM) ali genetsko (model miši MIN)
English: No clinically significant differences were found in pharmacokinetic parameters of celecoxib between African-Americans and Caucasians.
Slovenian: Med Afroameričani in belci niso ugotovili klinično pomembnih razlik v farmakokinetičnih parametrih celekoksiba.
English: You must not take Onsenal if you are breast feeding.
Slovenian: Zdravila Onsenal ne smete jemati, če dojite.
English: Cumulative rates for this composite endpoint over 3 years were 2.3% (21/933 subjects) and 1.9% (12/628 subjects), respectively.
Slovenian: Kumulativna deleža za ta sestavljeni opazovani dogodek v 3-letnem obdobju sta bila 2,3 % (21/933 preiskovancev) in 1,9 % (12/628 preiskovancev).
English: The mean reduction in the number of colorectal polyps following six months of treatment was 28% (SD + 24%) for celecoxib 400 mg BID which was statistically superior to placebo (mean 5%, SD +16%).
Slovenian: Število kolorektalnih polipov se je po šestmesečnem zdravljenju s 400 mg celekoksiba dvakrat na dan v povprečju zmanjšalo za 28 % (SD ± 24 %), kar je statistično bolje kot s placebom (povprečje 5 %, SD ±16 %).
English: Other Patients known to be CYP2C9 poor metabolisers should be treated with caution (see section 5.2).
Slovenian: Bolnike, za katere je znano, da slabo presnavljajo s CYP2C9, je treba zdraviti previdno (glejte poglavje 5.2).
English: Pharmacotherapeutic group: Antineoplastic, ATC code: L01XX33
Slovenian: Oznaka ATC: L01XX33
English: Because not all adverse drug reactions are reported to the MAH and included in the safety database, the frequencies of these reactions cannot be reliably determined.
Slovenian: Ker imetniku dovoljenja za promet niso prijavljeni vsi neželeni učinki zdravila, tudi niso vsi zajeti v podatkovno bazo o varnosti.
English: Blood and lymphatic system disorder / Cardio-vascular disorder Increased number of serious cardiovascular events, mainly myocardial infarction, has been found in a long-term placebo-controlled study in subjects with sporadic adenomatous polyps treated with celecoxib at doses of 200 mg BID and 400 mg BID compared to placebo (see section 5.1).
Slovenian: Bolezni krvi in limfatičnega sistema / Srčne in žilne bolezni V dolgotrajni, s placebom nadzorovani študiji, so odkrili povečano število nevarnih srčnožilnih dogodkov, v glavnem miokardni infarkt, pri osebah s sporadičnimi adenomatoznimi polipi, zdravljenih s celekoksibom, v odmerkih po 200 mg dvakrat na dan in 400 mg dvakrat na dan v primerjavi s placebom (glejte poglavje 5.1).
English: COX-2 selective inhibitors are not a substitute for acetylsalicylic acid for prophylaxis of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect.
Slovenian: Ker selektivni zaviralci COX-2 nimajo antiagregacijskega delovanja, niso nadomestilo za acetilsalicilno kislino v profilaksi kardiovaskularnih trombemboličnih bolezni.
English: Adverse drug reactions listed for the post-marketing population are only those that are not already listed for the arthritis trials (Table 1) or the polyp
Slovenian: Za pomarketinško populacijo so navedeni le tisti neželeni učinki zdravila, ki niso navedeni že za preskušanja pri artritisu (preglednica 1) ali za preskušanja pri preprečevanju polipov (preglednica 2).
English: The long-term cardiovascular toxicity in children exposed to celecoxib has not been evaluated and it is unknown if the long-term risk may be similar to that seen in adults exposed to celecoxib or other COX-2 selective and non-selective NSAIDs (see section 4.4; cardiovascular effects.
Slovenian: Tako ni znano, ali je dolgoročno tveganje morda podobno, kot je ugotovljeno pri odraslih osebah, izpostavljenih celekoksibu ali drugim COX-2 selektivnim in neselektivnim nesteroidnim protivnetnim zdravilom (glejte poglavje 4.4, Srčnožilni učinki).
English: In vitro studies have shown some potential for celecoxib to inhibit CYP2C19 catalysed metabolism.
Slovenian: Študije in vitro so pokazale, da lahko celekoksib do neke mere zavre presnovo, katalizirano s CYP2C19.
English: Patients with a history of sulphonamide allergy or any drug allergy may be at greater risk of serious skin reactions or hypersensitivity reactions (see section 4.3).
Slovenian: Resne kožne reakcije ali preobčutljivostne reakcije lahko bolj ogrožajo bolnike z anamnezo alergije na sulfonamide ali alergije na kakršnakoli zdravila (glejte poglavje 4.3).
English: − Meningitis (inflammation of the membrane around the brain and spinal cord)
Slovenian: - meningitis (vnetje ovojnic možganov in hrbtenjače)
English: The side effects listed below were observed in arthritis patients who took medicines with the same
Slovenian: Spodaj navedene neželene učinke so zabeležili pri bolnikih z artritisom, ki so jemali zdravila z isto učinkovino, kot jo vsebuje zdravilo Onsenal:
English: Results demonstrated a statistically significant reduction in polyp burden in all celecoxib treatment groups compared to the corresponding placebo treatment groups.
Slovenian: V primerjavi s skupinami, ki so dobivale placebo, so rezultati pokazali statistično pomembno zmanjšanje bremena polipov v vseh treh skupinah, zdravljenih s celekoksibom.
English: As with other NSAIDs, an increased risk of gastrointestinal ulceration or other gastrointestinal complications compared to use of celecoxib alone was shown for concomitant administration of low-dose acetylsalicylic acid (see section 5.1).
Slovenian: Tako kot pri drugih NSAID je tudi sočasno uporabo celekoksiba in majhnih odmerkov acetilsalicilne kisline spremljalo večje tveganje za ulkuse in druge zaplete na prebavilih kot pri uporabi celekoksiba samega (glejte poglavje 5.1).
English: The incidence of myocardial infarction (adjudicated) was 1.0% with (9/933 subjects) with celecoxib 400 mg once daily and 0.6% (4/628 subjects) with placebo.
Slovenian: Incidenca miokardnega infarkta (presojeno) je bila 1,0 % (9/933 preiskovancev) pri celekoksibu 400 mg enkrat na dan in 0,6 % (4/628 preiskovancev) pri placebu.
English: − The active substance is celecoxib
Slovenian: - Zdravilna učinkovina je celekoksib.
English: FAP is an inherited disorder in which the rectum and colon are covered with many polyps that might develop colorectal cancer.
Slovenian: FAP je prirojena bolezen, pri kateri sta danka in debelo črevo (kolon) prekrita s številnimi polipi, iz katerih se lahko razvije rak debelega črevesa ali danke.
English: Onsenal contains lactose (a type of sugar).
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Onsenal Zdravilo Onsenal vsebuje laktozo (vrsto sladkorja).
English: − Abnormal or heavy bleeding from the vagina, painful menstruation, breast pain, ovarian cyst,
Slovenian: - nenormalna ali močna krvavitev iz nožnice, boleča menstruacija, bolečine v dojkah,
English: Co-administration of NSAIDs and cyclosporine D derivatives or tacrolimus have been suggested to increase the nephrotoxic effect of cyclosporin and tacrolimus.
Slovenian: Sočasna uporaba NSAID in derivatov ciklosporina D ali takrolimusa naj bi zvečala njun nefrotoksični učinek.
English: Rare (≥1/10,000 to
Slovenian: Redki (≥ 1/10.000 do <
English: Polyps with the APC mutation overexpress COX-2 and left untreated, these polyps continue to form and enlarge in the colon or rectum resulting in essentially a 100% chance of developing colorectal cancer.
Slovenian: Če polipi ostanejo nezdravljeni, v predelu kolona in danke še naprej nastajajo in se večajo, kar se izteče v dejansko 100-odstotno možnost za kolorektalni karcinom.
English: Single doses up to 1200 mg and multiple doses up to 1200 mg twice daily have been administered to healthy subjects for nine days without clinically significant adverse events.
Slovenian: Zdravi preiskovanci so devet dni dobivali posamične odmerke do 1.200 mg in večkratne odmerke do 1.200 mg dvakrat na dan brez klinično pomembnih neželenih učinkov.
English: White, opaque capsules with two green bands marked 7767 and 400.
Slovenian: Bele, neprozorne kapsule z dvema zelenima črtama in oznakama 7767 in 400.
English: In a peri-post natal study in rats, pup toxicity was observed.
Slovenian: Med peri-/postnatalno študijo na podganah so opažali
English: Clear or opaque PVC/Aclar/Aluminium foil blisters.
Slovenian: Prozorni ali motni pretisni omoti iz PVC/aclar/aluminijske folije.
English: White, opaque capsules with two gold bands marked 7767 and 200.
Slovenian: Bele, neprozorne kapsule z dvema zlatima črtama in oznakama 7767 in 200.
English: Among patients treated with celecoxib 200 mg BID, 48% were considered unresponsive to lisinopril at the final clinic visit (defined as either cuff diastolic blood pressure >90 mmHg or cuff diastolic blood pressure increased >10% compared to baseline), compared to 27% of patients treated with placebo; this difference was statistically significant.
Slovenian: Med bolniki, zdravljenimi z 200 mg celekoksiba dvakrat na dan, je bilo na zadnjem ambulantnem pregledu 48 % ocenjenih kot neodzivnih za lizinopril (to je bilo opredeljeno kot z manšeto izmerjeni diastolični krvni tlak > 90 mmHg ali z manšeto izmerjeni diastolični krvni tlak za > 10 % nad izhodiščnim).
English: The dose of individually dose-titrated CYP2D6 substrates may need to be reduced when treatment with celecoxib is initiated or increased if treatment with celecoxib is terminated.
Slovenian: Po uvedbi zdravljenja s celekoksibom bo mogoče treba zmanjšati odmerek substratov CYP2D6, ki se odmerjajo individualno; po koncu zdravljenja s celekoksibom pa bo morda odmerek teh zdravil treba zvečati.
English: Serious hypersensitivity reactions (anaphylaxis and angioedema) have been reported in patients receiving celecoxib (see section 4.8).
Slovenian: Pri bolnikih, ki so dobivali celekoksib, so bile opisane resne preobčutljivostne reakcije (anafilaksija in angioedem) (glejte poglavje 4.8).
English: − Acetylsalcylic acid or other anti-inflammatory medicines
Slovenian: • Bolniki, ki so po jemanju acetilsalicilne kisline ali nesteroidnih protivnetnih zdravil (NSAID
English: Some people will need special care from their doctors when they are taking Onsenal.
Slovenian: Bodite posebno pozorni pri uporabi zdravila Onsenal Nekateri ljudje potrebujejo med jemanjem zdravila Onsenal posebno skrb svojega zdravnika.
English: These include some antibiotics (Bactrim and Septra used in combination of sulfamethoxazole and trimethoprim), which can be used to treat infections - if you have a stomach or duodenal ulcer, or bleeding in the stomach or intestines - if after taking aspirin or another anti-inflammatory medicine you have had nasal polyps or severe nasal congestion, or any allergic reaction such as an itchy skin rash, swelling, breathing
Slovenian: Med ta zdravila spadajo nekateri antibiotiki (Bactrim in Septra uporabljeni v kombinaciji s sulfametoksazolom in trimetoprimom), ki jih lahko uporabljamo za zdravljenje okužb - če imate razjedo na želodcu ali dvanajstniku ali krvavitev v želodcu ali črevesju - če ste kdaj po uporabi acetilsalicilne kisline ali kakšnega drugega protivnetnega zdravila imeli nosne polipe ali zelo zamašen nos ali ste doživeli kakšno alergijsko reakcijo, npr. srbeč kožni izpuščaj, otekanje ali piskajoče dihanje - če ste ženska v rodni dobi in ne uporabljate učinkovite kontracepcijske zaščite
English: Three metabolites, inactive as COX-1 or COX-2 inhibitors, have been identified in human plasma i.e., a primary alcohol, the corresponding carboxylic acid and its glucuronide conjugate.
Slovenian: Pri človeku so v plazmi našli tri presnovke: primarni alkohol, ustrezno karboksilno kislino in njen glukuronidni konjugat; vsi ti presnovki so kot zaviralci COX-1 ali COX-2 neaktivni.
English: Single doses up to 1400 mg and multiple doses up to 1400 mg twice daily have been administered to healthy subjects for nine days without clinically significant adverse events.
Slovenian: Zdravi preiskovanci so devet dni dobivali posamične odmerke do 1.400 mg in večkratne odmerke do 1.400 mg dvakrat na dan brez klinično pomembnih neželenih učinkov.
English: Clinical trials with celecoxib have shown renal effects similar to those observed with comparator NSAIDs.
Slovenian: Klinična preskušanja s celekoksibom so pokazala, da deluje to zdravilo na ledvice podobno kot primerjalna nesteroidna protivnetna zdravila.
English: − Low levels of sodium in blood test results (can cause loss of appetite, headache, nausea (feeling sick), muscle cramps and weakness)
Slovenian: - nizka koncentracija natrija v krvnih izvidih (lahko povzroči izgubo teka, glavobol, navzeo (slabost v želodcu), mišične krče in šibkost)
English: There is little experience of celecoxib in renal impairment and therefore caution is advised when treating patients with renal impairment.
Slovenian: Izkušenj s celekoksibom pri bolnikih z ledvično okvaro je malo, zato je pri zdravljenju takšnih bolnikov potrebna previdnost.
English: Ask your doctor for advice before taking both of these medicines together.
Slovenian: Preden ti dve zdravili vzamete skupaj, se posvetujte z zdravnikom.
English: In a pharmacokinetic study of celecoxib 200 mg administered once daily in healthy volunteers, genotyped as either CYP2C9*1/*1, CYP2C9*1/*3, or CYP2C9*3/*3, the median Cmax and AUC 024 of celecoxib on day 7 were approximately 4-fold and 7-fold, respectively, in subjects genotyped as CYP2C9*3/*3 compared to other genotypes.
Slovenian: V farmakokinetični študiji celekoksiba 200 mg enkrat na dan pri zdravih prostovoljcih, genotipiziranih kot CYP2C9*1/*1, CYP2C9*1/*3 ali CYP2C9*3/*3, je bila pri preiskovancih, genotipiziranih kot CYP2C9*3/*3, sedmi dan mediana Cmax celekoksiba 4-krat tolikšna, njegova mediana AUC 0-24 pa 7krat tolikšna kot pri drugih genotipih.
English: If a woman becomes pregnant during treatment, celecoxib
Slovenian: Če ženska med zdravljenjem zanosi, je treba uporabo celekoksiba prekiniti.
English: Bleeding events in association with increases in prothrombin time have been reported in arthritis patients (mainly elderly) receiving celecoxib concurrently with warfarin, some of them fatal (see section 4.4).
Slovenian: Pri bolnikih z artritisom (predvsem starejših), ki so dobivali celekoksib sočasno z varfarinom, so bile opisane krvavitve, povezane s podaljšanjem protrombinskega časa; nekatere od teh krvavitev so bile smrtne (glejte poglavje 4.4).
English: In the APC trial, the relative risks compared to placebo for a composite endpoint (adjudicated) of cardiovascular death, myocardial infarction, or stroke were 3.4 (95% CI 1.4 - 8.5) with celecoxib 400 mg twice daily and 2.8 (95% CI 1.1 - 7.2) with celecoxib 200 mg twice daily.
Slovenian: V preskušanju APC je bilo relativno tveganje za sestavljeni opazovani dogodek (presojeno) srčnožilne smrti, miokardnega infarkta ali možganske kapi v primerjavi s placebom pri celekoksibu 400 mg dvakrat na dan 3,4 (95 % IZ: 1,4-8,5) in pri celekoksibu 200 mg dvakrat na dan in 2,8 (95 % IZ: 1,17,2.
English: Compromised renal or hepatic function and especially cardiac dysfunction are more likely in the elderly and therefore medically appropriate supervision should be
Slovenian: Prizadeto delovanje ledvic ali jeter, še posebej pa moteno delovanje srca so verjetnejši pri starejših bolnikih.
English: Onsenal should be used along with the usual care for FAP patients such as surgery and endoscopic surveillance.
Slovenian: Zdravilo Onsenal je treba pri bolnikih s FAP uporabljati hkrati z običajno zdravstveno oskrbo, npr. operacijami
English: Heart failure, palpitations, tachycardia
Slovenian: Srčne bolezni srčno popuščanje, palpitacije, tahikardija miokardni infarkt
English: Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of celecoxib (see section 4.8).
Slovenian: Pri uporabi celekoksiba so zelo redko poročali o resnih kožnih reakcijah, nekatere od njih so bile smrtne, vključno z eksfoliacijskim dermatitisom, Stevens-Johnsonovim sindromom in toksično epidermalno nekrolizo (glejte poglavje 4.8).
English: In a pooled analysis of 20 placebo-controlled studies with duration greater than 2 weeks up to 1 year in patients with OA and RA, the excess rate of myocardial infarction in patients treated with celecoxib 200 or 400 mg daily over placebo was 0.7 events per 1000 patients (Rare) and there was no excess of strokes.
Slovenian: V kumulativni analizi 20 s placebom kontroliranih študij pri bolnikih z OA in RA, ki so trajale več kot 2 tedna in do 1 leta, je bil presežni delež miokardnega infarkta pri bolnikih, ki so dobivali 200 mg ali 400 mg celekoksiba na dan, v primerjavi s placebom 0,7 dogodka na 1000 bolnikov (redko).
English: You should check with your doctor or pharmacist if you are unsure.
Slovenian: Če ste negotovi, se posvetujte z zdravnikom ali s farmacevtom.
English: Outer carton - 400 mg hard capsules
Slovenian: Zunanja ovojnina - trde kapsule 400 mg
English: Take special care with ONSENAL
Slovenian: KAKO JEMATI ZDRAVILO ONSENAL
English: Outer carton - 200 mg hard capsules (clear, opaque blister)
Slovenian: Zunanja ovojnina - trde kapsule 200 mg (prozoren, moten pretisni omot)
English: Printing ink contains: shellac propylene glycol iron oxide (E172)
Slovenian: Črnilo vsebuje: šelak propilenglikol železov oksid (E172)
English: You will usually take two 200 mg
Slovenian: Ponavadi boste jemali po dve 200-mg kapsuli dvakrat na dan.
English: 6.3 Shelf life 3 years.
Slovenian: 6.3 Rok uporabnosti
English: SPECIAL STORAGE CONDITIONS Do not store above 30°C
Slovenian: Shranjujte pri temperaturi do 30 C.
English: − The printing ink contains also shellac, propylene glycol and iron oxide E172.
Slovenian: Črnilo vsebuje tudi šelak, propilenglikol in železov oksid E172.
English: Each capsule contains 200 mg celecoxib
Slovenian: Ena kapsula vsebuje 200 mg celekoksiba.
English: Such combinations should be avoided in known CYP2C9 poor metabolisers (see sections 4.2 and 5.2).
Slovenian: Pri bolnikih, za katere je znano, da slabopresnavljajo s CYP2C9, ne uporabljajte takšnih kombinacij (glejte poglavji 4.2 in 5.2).
English: − The printing ink contains also shellac, propylene glycol and iron oxide E172, Brilliant Blue FCF
Slovenian: Črnilo vsebuje tudi šelak, propilenglikol, železov oksid E172 in modro FCF E133.
English: Hypertension, hypertension aggravated
Slovenian: Žilne bolezni hipertenzija,
English: In a 28-day clinical study in patients with lisinopril-controlled Stage I and II hypertension, administration of celecoxib 200 mg BID resulted in no clinically significant increases, when compared to placebo treatment, in mean daily systolic or diastolic blood pressure as determined using 24-hour ambulatory blood pressure monitoring.
Slovenian: stopnje, urejeno z lizinoprilom, uporaba 200 mg celekoksiba dvakrat na dan v primerjavi s placebom ni klinično pomembno zvišala povprečnega sistoličnega ali diastoličnega krvnega tlaka med stalnim 24-urnim merjenjem.