FrancophonIA/ELRC3.0 huggingface dataset:
English: The concomitant use of potassium sparing diuretics, potassium supplements and potassium containing salt substitutes with losartan/ hydrochlorothiazide is not recommended (see section 4.5).
Slovenian: Sočasne uporabe diuretikov, ki varčujejo kalij, kalijevih dodatkov in nadomestkov soli, ki vsebujejo kalij, ter kombinacije losartan/hidroklorotiazid ne priporočamo (glejte poglavje 4.5).
English: Section 4.3 Contra-indications
Slovenian: Poglavje 4.3 Kontraindikacije
English: • if you suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of the hormone aldesterone by the adrenal gland, caused by an abnormality within the gland).
Slovenian: • če imate primarni hiperaldosteronizem (sindrom, povezan s povečanim izločanjem hormona aldosterona iz nadledvične žleze, zaradi okvare znotraj žleze).
English: • Loss of appetite, increased uric acid levels or frank gout, increased blood sugar levels, abnormal blood electrolyte levels,
Slovenian: • izguba apetita, povečana količina sečne kisline ali protin, povečana količina sladkorja v krvi, nenormalna vrednost elektrolitov v krvi
English: When pregnancy is diagnosed, treatment with Cozaar Comp should be stopped immediately and, if appropriate, alternative therapy should be started.
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z zdravilom Cozaar Comp takoj prekiniti, in, če je primerno, začeti alternativno zdravljenje.
English: As observed for angiotensin converting enzyme inhibitors, losartan and the other angiotensin antagonists are apparently less effective in lowering blood pressure in black people than in nonblacks, possibly because of higher prevalence of low-renin states in the black hypertensive population.
Slovenian: Tako kot so opazili za zaviralce angiotenzinske konvertaze, so tudi losartan in drugi antagonisti angiotenzina pri zmanjševanju krvnega tlaka pri črncih manj učinkoviti kot pri ostalih rasah, verjetno zaradi velike pojavnosti visokih vrednosti renina v črnski populaciji hipertonikov.
English: Losartan maintains glomerular filtration rate and reduces filtration fraction.
Slovenian: Losartan ne spremeni hitrosti glomerularne filtracije, zniža pa frakcijo filtracije.
English: Thiazides pass into human milk and may inhibit lactation.
Slovenian: Tiazidi pri človeku prehajajo v materino mleko in lahko zavirajo izločanje mleka.
English: At the time of the study, beta-blockade alone, or in combination with diuretics had shown to reduce rates of many CV events by 15-45%.
Slovenian: Med študijo so dokazali, da samostojno zaviralno delovanje na beta receptorje ali v kombinaciji z diuretiki zmanjša odstotek mnogih kardiovaskularnih dogodkov za 15-45 %.
English: • if you have or have had an allergic condition, asthma or a condition that causes joint pain, skin rashes and fever (systemic lupus erythematodus).
Slovenian: • če imate ali ste imeli alergijo, astmo ali bolezen, ki povzroča bolečine v sklepih, kožne izpuščaje in zvišano telesno temperaturo (sistemski eritematozni lupus).
English: In a study specifically designed to assess the incidence of cough in patients treated with losartan as compared to patients treated with ACE inhibitors, the incidence of cough reported by patients receiving losartan or hydrochlorothiazide was similar and was significantly less than in patients treated with an ACE inhibitor.
Slovenian: V študiji, zasnovani posebej za oceno pojavnosti kašlja pri bolnikih, zdravljenih z losartanom, v primerjavi z bolniki, zdravljenimi z zaviralci ACE, je bila pojavnost kašlja pri bolnikih, ki so prejemali losartan ali hidroklorotiazid podobna in pomembno manjša kot pri bolnikih, zdravljenih z zaviralcem ACE.
English: The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis.
Slovenian: Najpogostejši znaki in simptomi, ki so jih opazili, so tisti, ki jih povzročata zmanjšana količina elektrolitov (hipokaliemija, hipokloremija, hiponatriemija) in dehidracija zaradi močne diureze.
English: Common (affecting less than one person in 10 but more than one person in 100):
Slovenian: Pogosti (pojavijo se pri manj kot eni od 10 oseb in več kot eni od 100 oseb):
English: Concomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Slovenian: Sočasna uporaba antagonistov angiotenzina II ali diuretikov in NSAR-ov lahko poveča tveganje za poslabšanje ledvične funkcije, vključno z akutno ledvično odpovedjo, ter poveča količino kalija v serumu, še posebej pri bolnikih z že obstoječim slabim delovanjem ledvic.
English: The active metabolite is 10- to 40-times more active than losartan on a weight for weight basis.
Slovenian: Aktivni presnovek je 10- do 40-krat bolj aktiven kot losartan (v isti količini).
English: Preparations containing lithium should not be taken with Cozaar Comp without close supervision by your doctor.
Slovenian: Pripravki, ki vsebujejo litij, se v kombinaciji z zdravilom Cozaar Comp brez natančnega nadzora zdravnika ne smejo uporabljati.
English: • if you have high calcium or low potassium levels or you are on a low potassium diet
Slovenian: • če imate visoko vrednost kalcija ali nizko vrednost kalija ali ste na dieti z zmanjšanim vnosom kalija.
English: Just resume your usual schedule.
Slovenian: Nadaljujte z običajnim jemanjem.
English: Slovenia Merck Sharp & Dohme, inovativna zdravila d.o.o., Smartinska cesta 140, 1000 Ljubljana
Slovenian: Merck Sharp & Dohme, inovativna zdravila d.o.o., Smartinska cesta 140, 1000 Ljubljana, Slovenija
English: Like all medicines, Cozaar Comp tablets can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila, ima lahko tudi zdravilo Cozaar Comp neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Cozaar Comp is supplied in the following pack sizes:
Slovenian: Cozaar Comp je na voljo v naslednjih pakiranjih:
English: Rifampicin and fluconazole have been reported to reduce levels of active metabolite.
Slovenian: Poročali so, da rifampicin in flukonazol zmanjšata količino aktivnega presnovka.
English: Hydrochlorothiazide (HCTZ) is a thiazide diuretic which has also been used as an antihypertensive agent.
Slovenian: Hidroklorotiazid (HCTZ) je tiazidni diuretik, ki so ga uporabljali tudi kot sredstvo proti hipertenziji.
English: The LIFE study has been assessed in the past and this has led to the registration of the more extensive indication, i.e. the reduction of the cardiovascular morbidity and mortality (as measured by the combined incidence of CV death, stroke and MI) instead of stroke only.
Slovenian: Študijo LIFE so že ocenili v preteklosti, zaradi česar je prišlo do registracije razširjene indikacije, tj. zmanjšanje kardiovaskularne obolevnosti in umrljivosti (kot je bilo izmerjeno s kombinirano pojavnostjo kardiovaskularnih smrti, možganskih kapi ter miokardnih infarktov), namesto uporabe samo izraza možganska kap.
English: Amphotericin B (parenteral), corticosteroids, ACTH or stimulant laxatives Hydrochlorothiazide may intensify electrolyte imbalance, particularly hypokalaemia.
Slovenian: Amfotericin B (parenteralni), kortikosteroidi, ACTH ali kontaktna odvajala Hidroklorotiazid lahko poslabša neravnovesje elektrolitov, še posebej hipokaliemijo.
English: As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function, including renal failure, have been reported (in particular, in patients whose renal function is dependent on the renin-angiotensin-aldosterone system, such as those with severe cardiac insufficiency or pre-existing renal dysfunction).
Slovenian: Zaradi zaviranja sistema renin-angiotenzin-aldosteron so poročali o spremembah delovanja ledvic, vključno z ledvično odpovedjo (še posebej pri bolnikih, katerih ledvična funkcija je odvisna od sistema renin-angiotenzin-aldosteron, kot je pri bolnikih s hudo srčno insuficienco ali že obstoječimposlabšanjem delovanja levic).
English: Losartan is an orally active angiotensin II (Ang- II) receptor antagonist acting on the AT1 receptor subtype, thus blocking the effect of Ang-II in the renin angiotensin system (RAS) cascade.
Slovenian: Losartan je peroralno aktiven antagonist receptorja angiotenzina II (Ang-II), ki deluje na receptor podtipa AT1 in s tem zavira učinke Ang-II v kaskadi renin angiotenzinskega sistema (RAS).
English: No specific information is available on the treatment of overdosage with Cozaar Comp.
Slovenian: O zdravljenju prevelikega odmerjanja zdravila Cozaar Comp nimamo specifičnih informacij.
English: Merck Sharp & Dohme OÜ Peterburi tee 46, Tallinn 11415, Estonia
Slovenian: Merck Sharp & Dohme OÜ Peterburi tee 46, Talin 11415, Estonija
English: • Severe renal impairment (i.e. creatinine clearance <30 ml/min)
Slovenian: • Huda okvara ledvic (tj. kreatininski očistek < 30 ml/min).
English: The CHMP considered that the following contra-indications should be included in the SPC in all MSs: Severe renal impairment; Electrolyte disturbances such as hyponatremia, hypokalemia, hypercalcemia; Hyperuricaemia; Pregnancy and lactation; LAPP lactose deficiency; Liver insufficiency; Addison's disease.
Slovenian: CHMP je menil, da je treba v vseh različicah povzetka glavnih značilnosti zdravila vključiti naslednje kontraindikacije: huda okvara ledvic; motnje elektrolitov, kot so hiponatremija, hipokalemija, hiperkalcemija, hiperuricemija; nosečnost in dojenje; Lappovo pomanjkanje laktaze; jetrna insuficienca; Addisonova bolezen.
English: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Slovenian: Absorpcija hidroklorotiazida je motena v prisotnosti smol, ki so anionski izmenjevalci.
English: EXPO 2000, east wing, sections B1 & B2, 1st fl.
Slovenian: 55 Nikola Vaptzarov blvd. EXPO 2000, east wing, sections B1 & B2, 1st fl.
English: • if you have low potassium, low sodium or high calcium levels which cannot be corrected by treatment
Slovenian: • če imate nizko vrednost kalija, nizko vrednost natrija ali visoko vrednost kalcija, ki se jih ne da pozdraviti.
English: • if you have narrow arteries to your kidneys (renal artery stenosis) or only have one functioning kidney, or you have recently had a kidney transplant
Slovenian: • če imate zožane arterije, ki vodijo do ledvic (stenoza ledvične arterije) ali vam deluje samo ena ledvica ali pa so vam pred kratkim presadili ledvico.
English: When pregnancy is diagnosed, treatment with Cozaar Comp should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z zdravilom Cozaar Comp takoj prekiniti in, če je primerno, začeti alternativno zdravljenje (glejte poglavji 4.3 in 4.6).
English: Losartan/HCTZ tablets must not be used in patients with severe renal impairment (i.e. creatinine clearance <30 ml/min) (see section 4.3).
Slovenian: Tablet losartan/HCTZ ne smejo jemati bolniki s hudo ledvično okvaro (to je s kreatininskim očistkom < 30 ml/min) (glejte poglavje 4.3).
English: Anticholinergic agents (e.g. atropine, biperiden)
Slovenian: Antiholinergiki (npr. atropin, biperiden)
English: Via G Fabbroni 6, 00191 Rome Italy
Slovenian: Via G Fabbroni 6, 00191 Rim, Italija
English: They may cause fetal electrolyte disturbances and possibly other reactions that have been observed in adults.
Slovenian: Pri plodu lahko porušijo ravnovesje elektrolitov in verjetno povzročijo tudi druge reakcije kot pri odraslih.
English: There was no relevant difference in the number of patients with severe hypertension showing a relevant BP lowering effect during the first 4 weeks.
Slovenian: Pomembnih razlik v številu bolnikov s hudo hipertenzijo, pri katerih je bilo v prvih štirih tednih opaziti učinek pomembnega znižanja krvnega tlaka, ni bilo.
English: • Hypersensitivity to losartan, sulphonamide-derived substances (as hydrochlorothiazide) or to any of the excipients
Slovenian: • Preobčutljivost za losartan, derivate sulfonamidov (kot je hidroklorotiazid) ali katerokoli pomožno snov.
English: As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
Slovenian: Kot pri drugih zdravilih, ki zavirajo angiotenzin II ali njegove učinke, lahko sočasna uporaba diuretikov, ki varčujejo kalij (npr. spironolaktona, triamterena, amilorida), dodatkov kalija ali nadomestkov soli, ki vsebujejo kalij, povzroči zvišanje vrednosti kalija v serumu.
English: When plasma levels have been followed for at least 24 hours, the plasma half-life has been observed to vary between 5.6 and 14.8 hours.
Slovenian: Po najmanj 24-urnem spremljanju plazemske koncentracije so opazili spremenljiv plazemski razpolovni čas od 5,6 do 14,8 ur.
English: Marked hypercalcemia may be evidence of hidden hyperparathyroidism.
Slovenian: Znatna hiperkalciemija je lahko pokazatelj skritega hiperparatiroidizma.
English: Limited data are available in regard to overdosage in humans.
Slovenian: Podatkov o prevelikem odmerjanju pri ljudeh je malo.
English: Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney.
Slovenian: Hidroklorotiazid se ne presnavlja, ampak se hitro izloči skozi ledvice.
English: Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant.
Slovenian: Nedepolarizirajoči relaksanti skeletnih mišic (npr. tubokurarin) Možna je povečana odzivnost na mišični relaksant.
English: Suggested measures include induction of emesis if ingestion is recent, and correction of dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures.
Slovenian: Priporočeni ukrepi zajemajo izzvanje bruhanja, če je bilo zdravilo zaužito pred kratkim, ter korekcijo dehidracije, elektrolitskega neravnovesja, hepatične kome in hipotenzije po ustaljenih metodah.
English: It is also important for your doctor to know if you are taking other medicines to reduce your blood pressure, steroids, medicines to treat cancer, pain killers, drugs for treatment of fungal infections, or arthritis medicines, resins used for high cholesterol, such as colestyramine, medicines which relax your muscles, sleeping tablets; opioid medicines such as morphine , ‘pressor amines' such as adrenaline or other drugs from the same group; (oral agents for diabetes or insulins).
Slovenian: Pomembno je, da vaš zdravnik ve, če jemljete še druga zdravila za zniževanje krvnega tlaka, steroide, zdravila za zdravljenje raka, zdravila za bolečine, zdravila za zdravljenje glivičnih okužb, zdravila za artritis, smole za zdravljenje povišanega holesterola, kot je holestiramin, zdravila za sprostitev mišic, uspavala, opioidna zdravila kot je morfin, presorni amini, kot je adrenalin ali druga zdravila iz iste skupine.
English: In patients receiving thiazides, hypersensitivity reactions may occur with or without a history of allergy or bronchial asthma.
Slovenian: Pri bolnikih, ki dobivajo tiazide, se lahko pojavijo preobčutljivostne reakcije ne glede na to, ali so kdaj imeli alergije ali bronhialno astmo, ali ne.
English: Therefore, the plasma concentrations of potassium and creatinine clearance values should be closely monitored; especially patients with heart failure and a creatinine clearance between 30-50 ml/ min should be closely monitored.
Slovenian: Zato je treba pozorno spremljati plazemske koncentracije kalija ter kreatininski očistek, še posebej pri bolnikih s srčnim popuščanjem in kreatininskim očistkom 3050 ml/min.
English: Patients should be observed for clinical signs of fluid or electrolyte imbalance, e.g., volume depletion, hyponatremia, hypochloremic alkalosis, hypomagnesemia or hypokalemia which may occur during intercurrent diarrhea or vomiting.
Slovenian: Bolnike je treba nadzorovati zaradi morebitnega pojava kliničnih znakov neravnovesja tekočin ali elektrolitov, npr. zmanjšanja volumna, hiponatriemije, hipokloremične alkaloze, hipomagneziemije ali hipokaliemije, ki se lahko pojavijo med vmesno diarejo ali bruhanjem.
English: • if you are allergic (hypersensitive) to losartan, hydrochlorothiazide or to any of the other ingredients in this medicine.
Slovenian: • če ste alergični na (preobčutljivi za) losartan, hidroklorotiazid ali katerokoli sestavino zdravila.
English: Additional adverse events that have been seen with one of the individual components and may be potential adverse events with losartan potassium/ hydrochlorothiazide are the following:
Slovenian: Dodatni neželeni učinki, ki so jih opazili pri eni od učinkovin in so lahko možni neželeni učinki kombinacije kalijev losartanat/hidroklorotiazid, so:
English: In some patients with compromised renal function who are being treated with non-steroidal antiinflammatory drugs, including selective cyclooxygenase-2 inhibitors, the co-administration of angiotensin II receptor antagonists may result in a further deterioration of renal function.
Slovenian: Pri nekaterih bolnikih z oslabljenim delovanjem ledvic, ki se zdravijo z nesteroidnimi antirevmatiki, vključno s selektivnimi zaviralci ciklooksigenaze-2, lahko sočasna uporaba antagonistov receptorjev angiotenzina II povzroči nadaljnje slabšanje delovanja ledvic.
English: • Ringing, buzzing, roaring or clicking in the ears,
Slovenian: • zvonjenje, brenčanje, bobnenje v ušesih
English: LIST OF EXCIPIENTS Lactose-monohydrate.
Slovenian: SEZNAM POMOŽNIH SNOVI Laktoza monohidrat.
English: After oral use, diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours the antihypertensive effect persists for up to 24 hours.
Slovenian: Po peroralni uporabi se diureza začne v 2 urah, maksimum doseže v 4 urah in traja 6 do 12 ur.
English: Alcohol, barbiturates, narcotics or antidepressants: Potentiation of orthostatic hypotension may occur.
Slovenian: Alkohol, barbiturati, narkotiki ali antidepresivi Okrepijo lahko ortostatsko hipotenzijo.
English: Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, as it may cause intrahepatic cholestasis, and since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Slovenian: Tiazide je treba uporabljati previdno pri bolnikih z okvaro jetrne funkcije ali napredovalo boleznijo jeter, ker lahko povzročijo intrahepatično holestazo in zaradi manjših sprememb razmerja tekočin in elektrolitov izzovejo jetrno komo.
English: In clinical trials, after 12 weeks of therapy with losartan 50 mg/hydrochlorothiazide 12.5 mg, trough sitting diastolic blood pressure was reduced by an average of up to 13.2 mmHg.
Slovenian: V kliničnih preizkušanjih se je po 12-tedenskem zdravljenju z losartanom 50 mg/hidroklorotiazidom 12,5 mg diastolični krvni tlak, izmerjen sede tik pred naslednjim odmerkom, znižal za povprečno 13,2 mmHg.
English: Should exposure to Cozaar Comp have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Slovenian: V primeru izpostavljenosti zdravilu Cozzar Comp od drugega trimesečja nosečnosti dalje se priporoča ultrazvočni pregled lobanje in delovanja ledvic.
English: Because of their effects on calcium metabolism, thiazides may interfere with tests for parathyroid function (see section 4.4).
Slovenian: Zaradi svojih učinkov na presnovo kalcija lahko tiazidi vplivajo na izvid testov paratiroidne funkcije (glejte poglavje 4.4).
English: Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patients, Cozaar Comp should be used with caution in patients with a history of mild to moderate hepatic impairment.
Slovenian: Glede na farmakokinetične podatke, ki kažejo pomembno zvišanje plazemskih koncentracij losartana pri bolnikih s cirozo, je treba pri bolnikih, ki so kdaj imeli blago do zmerno okvaro jeter, zdravilo Cozaar Comp previdno uporabljati.
English: • Anaemia, red or brownish spots on the skin (sometimes especially on the feet, legs, arms and buttocks, with joint pain, swelling of the hands and feet and stomach pain), bruising, reduction in white blood cells, clotting problems and bruising,
Slovenian: • anemija, rdeče ali rjavkaste lise na koži (včasih posebno na stopalih, nogah, rokah in zadnjici, z bolečinami v sklepih, otekanjem dlani in stopal in bolečinami v želodcu), modrice, zmanjšano število belih krvnih celic, motnje strjevanja krvi in modrice
English: Concomitant treatment with cyclosporine may increase the risk of hyperuricaemia and gout-type complications.
Slovenian: Sočasno zdravljenje s ciklosporinom lahko poveča tveganje za hiperurikemijo in s protinom povezane zaplete.
English: As a consequence the observed 25% risk reduction with losartan versus atenolol brings the protective effect of losartan on stroke in the same range as for other antihypertensives.
Slovenian: Zaradi tega spada opaženo 25 % zmanjšanje tveganja pri uporabi losartana v primerjavi z atenololom po zaščitnem učinku losartana proti možganski kapi v isti razpon kot učinek drugih zdravil proti hipertenziji.
English: When angiotensin II antagonists are administered simultaneously with NSAIDs (i.e. selective COX-2 inhibitors, acetylsalicylic acid at anti-inflammatory doses) and non-selective NSAIDs, attenuation of the antihypertensive effect may occur.
Slovenian: Če se antagonisti angiotenzina II uporabljajo sočasno z nesteroidnimi antirevmatiki (NSAR) (tj. selektivnimi zaviralci COX-2, acetilsalicilno kislino v protivnetnih odmerkih in neselektivnimi NSAR-i) se lahko antihipertenzivni učinek zmanjša.
English: WHAT COZAAR COMP IS AND WHAT IT IS USED FOR Cozaar Comp is a combination of an angiotensin II receptor antagonist (losartan) and a diuretic (hydrochlorothiazide).
Slovenian: KAJ JE ZDRAVILO COZAAR COMP IN ZA KAJ GA UPORABLJAMO Zdravilo Cozaar Comp je kombinacija antagonista angioetnzina II (losartana) in diuretika (hidroklorotiazida).
English: As the MAH did not submit data to demonstrate a clear population that would benefit from the FDC with regards to cardiovascular outcome, the benefit/risk of the indication in first line could be assessed and the indication is not warranted by the CHMP.
Slovenian: Ker imetnik dovoljenja za promet z zdravilom ni predložil podatkov, s katerimi bi pokazal jasno opredeljeno populacijo, ki bi imela pri kardiovaskularnih rezultatih koristi od fiksne kombinacije odmerkov, razmerja med koristnimi učinki in tveganjem za indikacijo zdravljenja prve izbire ni bilo mogoče oceniti, tako da CHMP ni dal svojega jamstva.
English: Following oral administration, losartan is well absorbed and undergoes first-pass metabolism, forming an active carboxylic acid metabolite and other inactive metabolites.
Slovenian: Po peroralnem zaužitju se losartan dobro absorbira in je podvržen presnovi prvega prehoda, kjer nastajajo aktivni karboksikislinski presnovek in ostali neaktivni presnovki.
English: The usual dose of Cozaar Comp for most patients with high blood pressure is 1 tablet of Cozaar Comp 50 mg/12.5 mg per day to control blood pressure over the 24-hour period.
Slovenian: Običajni odmerek zdravila Cozaar Comp za večino bolnikov z visokim krvnim tlakom je 1 tableta Cozaar Comp 50 mg /12,5 mg na dan za 24-urni nadzor krvnega tlaka.
English: The toxic potential of the combination of losartan/hydrochlorothiazide was evaluated in chronic toxicity studies for up to six months duration in rats and dogs after oral administration, and the changes observed in these studies with the combination were mainly produced by the losartan component.
Slovenian: Toksični potencial kombinacije losartan/hidroklorotiazd so ovrednotili v študijah kronične toksičnosti, ki so trajale do šest mesecev, pri podganah in psih, ki so jim kombinacijo dajali peroralno.