FrancophonIA/ELRC3.0 huggingface dataset:
English: For patients unable to swallow the film-coated tablets, the tablets may be dispersed in a glass of mineral water or apple juice.
Danish: Til patienter (børn), der ikke er i stand til at synke tabletterne, kan indholdet opløses i et glas almindeligt vand eller æblejuice.
English: The estimated rate of progression-free survival at 84 months was 81.2% in the Imatinib arm and 60.6% in the control arm (p<0.001).
Danish: Den estimerede progressionsfri overlevelse efter 84 måneder var 81,2 % i Imatinib-armen og 60,6 % i kontrolarmen (p<0,001).
English: Total bilirubin: = 1.5 ULN AST: > ULN (can be normal or < ULN if total bilirubin is > ULN)
Danish: ASAT: >ULN (kan være normal eller <ULN hvis total bilirubin er >ULN)
English: The safety database for children and adolescents with Ph+ALL is very limited though no new safety concerns have been identified.
Danish: Sikkerhedsdatabasen for børn og unge med Ph+ ALL er meget begrænset.
English: Maximal plasma concentrations of imatinib in patients are 2-4 µmol/l, consequently an inhibition of CYP2D6 and/or CYP3A4/5-mediated metabolism of co-administered drugs is possible.
Danish: Maksimale plasmakoncentrationer af imatinib er hos patienter 2-4 mol/l, og hæmning af CYP2D6 og/eller CYP3A4/5-medieret metabolisme af samtidigt administrerede lægemidler er derfor mulig.
English: • adult patients with unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery.
Danish: • voksne patienter med inoperabel dermatofibrosarkom protuberans (DFSP) og voksne patienter med residiverende og/eller metastaserende DFSP som ikke er tilgængelig for kirurgi.
English: CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Danish: SIKKER OG EFFEKTIV ANVENDELSE AF LÆGEMIDLET
English: The yearly rates of progression of any type for Imatinib also decreased over time.
Danish: Årlige frekvenser af enhver type progression blev reduceret over tid med Imatinib.
English: Imatinib was administered intermittently in cohorts 1-5, with increasing duration and earlier start of imatinib from cohort to cohort; cohort 1 receiving the lowest intensitiy and cohort 5 receiving the highest intensity of imatinib (longest duration in days with continuous daily imatinib dosing during the first chemotherapy treatment courses).
Danish: Imatinib blev administreret periodisk i kohorte 1-5 med stigende varighed og tidligere start med imatinib fra kohorte til kohorte; kohorte 1 fik den mindst intensive imatinibbehandling og kohorte 5 den mest intensive (længste varighed i dage med kontinuerlig, daglig imatinib-dosering i de første kemobehandlingsforløb).
English: • Do not use this medicine after the expiry date which is stated on the carton and blister after
Danish: • Brug ikke lægemidlet efter den udløbsdato, der står på pakningen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Whereas an estimated 96% (93%) of patients with CCyR (PCyR) at 12 months were free of progression to accelerated phase/blast crisis at 84 months, only 81% of patients without MCyR at 12 months were free of progression to advanced CML at 84 months (p<0.001 overall, p=0.25 between CCyR and PCyR).
Danish: Hvor estimeret 96 % (93 %) af patienterne med CCyR (PCyR) ved 12 måneder var fri for progression til accelereret fase/blastkrise ved 84 måneder, var kun 81 % af patienterne uden CCyR ved 12 måneder fri for progression til fremskreden CML ved 84 måneder (p<0,001 samlet, p=0,25 mellem CCyR og PCyR).
English: Musculoskeletal pain during treatment with imatinib or after discontinuation has been observed in post-marketing.
Danish: 9 Muskuloskeletale smerter under behandling med imatinib eller efter seponering er blevet observeret efter markedsføring.
English: Packs containing 20, 60, 120 or 180 film-coated tablets.
Danish: Pakninger indeholdende 20, 60, 120 eller 180 filmovertrukne tabletter.
English: In this retrospective analysis, the superiority of Imatinib over IFN+Ara-C in overall survival was demonstrated (p<0.001); within 42 months, 47 (8.5%) Imatinib patients and 63 (19.4%) IFN+Ara-C patients had died.
Danish: I denne retrospektive analyse af total overlevelse blev Imatinibs overlegenhed vist i forhold til IFN+AraC (p<0,001); inden for 42 måneder var 47 (8,5 %) Imatinib-patienter og 63 (19,4 %) IFN+Ara-Cpatienter døde.
English: Carriers of HBV who require treatment with Imatinib Accord should be closely monitored for signs and symptoms of active HBV infection throughout therapy and for several months following termination of therapy (see section 4.8).
Danish: Bærere af HBV, hvor behandling med Imatinib Accord er nødvendig, skal overvåges tæt for tegn og symptomer på aktiv HBV-infektion i hele behandlingsperioden og i flere måneder efter behandlingsophør (se pkt.
English: BCR-ABL tyrosine kinase inhibitors (TKIs) have been associated with thrombotic microangiopathy (TMA), including individual case reports for Imatinib Accord (see section 4.8).
Danish: BCR-ABL-tyrosinkinasehæmmere (TKI'er) er blevet associeret med trombotisk mikroangiopati (TMA), herunder enkeltstående rapporter for imatinib (se pkt.
English: Imatinib Accord inhibits the growth of these cells in a certain subtype of these diseases.
Danish: Imatinib Accord hæmmer væksten af disse celler i en vis undergruppe af disse sygdomme.
English: Metabolism of imatinib is mainly hepatic, and only 13% of excretion is through the kidneys.
Danish: Imatinib metaboliseres primært i leveren, og kun 13% udskilles via nyrerne.
English: Pretreatment with multiple doses of rifampicin 600 mg followed by a single 400 mg dose ofimatinibresulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment.
Danish: Præbehandling med gentagne doser af rifampicin 600 mg efterfulgt af enkeltdosis Imatinib 400 mg resulterede i fald i Cmax og AUC(0-∞) på mindst 54% og 74% af værdierne uden rifampicinbehandling.
English: However, always take this medicine exactly as your doctor or pharmacist has told you.
Danish: Tag altid lægemidlet nøjagtigt efter lægens eller apotekspersonalets anvisning.
English: Patients on imatinib treatment who are concerned about their fertility should consult with their physician.
Danish: Patienter, får behandling med Imatinib Accord og er bekymrede for deres fertilitet, bør konsultere deres læge.
English: Imatinib was teratogenic in rats when administered during organogenesis at doses ≥ 100 mg/kg, approximately equal to the maximum clinical dose of 800 mg/day, based on body surface area.
Danish: Imatinib var teratogent hos rotter ved administration under organgenese ved doser ≥100 mg/kg, ca. svarende til den maksimale kliniske dosis på 800 mg/dag, baseret på legemsoverfladeareal.
English: • adult and paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase or blast crisis.
Danish: • voksne og børn med Ph+ CML i kronisk fase efter manglende effekt af alfainterferonbehandling, eller i accelereret fase eller blastkrise.
English: In vitro, imatinib inhibits paracetamol O-glucuronidation with Ki value of 58.5 micromol/l.
Danish: In vitro hæmmer Imatinib O-glucuronidationen af paracetamol med en Ki-værdi på 58,5 mikromol/l.
English: Women of childbearing potential must be advised to use effective contraception during treatment.
Danish: Kvinder i den fertile alder Kvinder i den fertile alder skal tilrådes at anvende sikker kontraception under behandlingen.
English: • adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with platelet-derived growth factor receptor (PDGFR) gene re-arrangements.
Danish: • voksne patienter med myelodysplastisk syndrom/myeloproliferative sygdomme (MDS/MPD) som er forbundet med platelet-derived growth factor receptor-omlejring (PDGFR-omlejring).
English: In the study in patients with unresectable and/or metastatic GIST, 7 (5%) patients experienced CTC grade 3/4 GI bleeds (3 patients), intra-tumoural bleeds (3 patients) or both (1 patient).
Danish: I undersøgelsen med patienter med inoperabel og/eller metastaserende GIST, oplevede 7 (5%) af patienterne CTC grad 3-4: gastrointestinale blødninger (3 patienter), intra-tumorale blødninger (3 patienter) eller begge dele (1 patient).
English: - The other ingredients are microcrystalline cellulose, crospovidone, hypromellose 6 cps (E464), magnesium stearate and anhydrous colloidal silica.The tablet coating is made of hypromellose 6 cps (E464), talc (E553b), polyethylene glycol, iron oxide yellow (E172) and iron oxide red (E172).
Danish: - Øvrige indholdsstoffer: mikrokrystallinsk cellulose, crospovidon, hypromellose 6 cps (E464), magnesiumstearat og vandfri kolloid silica.Tabletovertrækket består af hypromellose 6 cps (E464), talkum (E553b), polyethylenglycol, gul jernoxid (E172) og rød jernoxid (E172).
English: Table 4 Chemotherapy regimen used in combination with imatinib
Danish: Tabel 4 Kemoterapiregime anvendt i kombination med imatinib
English: Major response n (%) [95% CI]
Danish: Cytogenetisk respons Major respons n (%) [95 % CI]
English: The European Medicines Agency has waived the obligation to submit the results of studies with imatinib in all subsets of the paediatric population in Philadelphia chromosome (bcr-abl translocation)-positive chronic myeloid leukaemia (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med imatinib i alle undergrupper af den pædiatriske population med Philadelphiakromosom (bcr-abl translokation)-positiv kronisk myeloid leukæmi (se pkt.
English: ANC = absolute neutrophil count aoccurring after at least 1 month of treatment Special populations Hepatic insufficiency
Danish: ANC = fuldstændigt antal neutrofilocytter aopstået efter mindst 1 måneds behandling
English: A total of 26 paediatric patients of age < 18 years with either chronic phase CML (n=11) or CML in blast crisis or Ph+ acute leukaemias (n=15) were enrolled in a dose-escalation phase I trial.
Danish: Pædiatriske patienter: Ialt 26 pædiatriske patienter i alderen <18 år med enten CML i kronisk fase (n=11) eller CML i blastkrise eller Ph+ akut leukæmi (n=15) blev inkluderet i en fase I undersøgelse med dosis-eskalering.
English: Imatinib Accord is a treatment for adults and children and adolescents for:
Danish: Imatinib Accord er en behandling til voksne og børn og unge mod:
English: If tolerated, the dose can be increased for lack of efficacy (see sections 4.4 and
Danish: Hvis dosis tolereres, kan den øges ved manglede effekt (se pkt.
English: In the study in patients with unresectable and/or metastatic GIST, grade 3 and 4 anaemia was reported in 5.4% and 0.7% of patients, respectively, and may have been related to gastrointestinal or intra-tumoural bleeding in at least some of these patients.
Danish: I undersøgelsen med patienter med inoperabel og/eller metastaserende GIST rapporteredes anæmi grad 3 og 4 hos henholdsvis 5,4% og 0,7% af patienterne, hvilket kan hænge sammen med gastrointestinal eller intra-tumoral blødning, i hvert fald hos enkelte af patienterne.
English: Three large, international, open-label, non-controlled phase II studies were conducted in patients with Philadelphia chromosome positive (Ph+) CML in advanced blast or accelerated phase disease, other Ph+ leukaemias or with CML in the chronic phase but failing prior interferon-alpha (IFN) therapy.
Danish: Der er udført tre store, internationale, åbne, ikke-kontrollerede fase II-undersøgelser med patienter med Philadelphia-kromosompositiv (Ph+) CML i fremskreden blastkrise eller accelereret fase, andre Ph+ - leukæmier eller med CML i kronisk fase men tidligere behandlet med alfa-interferonbehandling (IFN) uden effekt.
English: In the 2-year rat carcinogenicity study administration of imatinib at 15, 30 and 60 mg/kg/day resulted in a statistically significant reduction in the longevity of males at 60 mg/kg/day and females at ≥ 30 mg/kg/day.
Danish: I et 2-års karcinogenicitetsstudie i rotter resulterede administration af imatinib på 15, 30 og 60 mg/kg/dag i en signifikant reduktion i levetiden ved 60 mg/kg/dag for hanner og for hunner ved ≥30 mg/kg/dag.
English: If you are being treated for DFSP
Danish: Hvis du behandles for DSFP
English: Resume treatment with Imatinib Accord at 600 mg.
Danish: Genoptag behandling med Imatinib Accord 600 mg.
English: PVC/PVdC/Alu or Alu/Alu blisters.
Danish: PVC/PVdC/aluminium-blister eller alu/alu-blister.
English: The total daily dose in children and adolescents must not exceed 800 mg with CML and 600 mg with Ph+ALL.
Danish: Den totale daglige dosis til børn og unge må ikke overstige 800 mg for CML-patienter og 600 mg for Ph+ALL-patienter.
English: The free drug clearance of imatinib is probably similar between renal impairment and those with normal renal function, since renal excretion represents only a minor elimination pathway for imatinib (see sections 4.2 and 4.4).
Danish: Udskilning af fri imatinib er sandsynligvis sammenlignelig for nedsat nyrefunktion og normal nyrefunktion, eftersom udskillelse via nyren kun udgør en mindre elimineringsvej for imatinib (se pkt.
English: In this study, 14 patients with HES/CEL were treated with 100 mg to 1,000 mg of imatinib daily.
Danish: I dette studie blev 14 patienter med HES/CEL behandlet med 100 mg1.000 mg imatinib daglig.
English: Chronic phase CML is defined when all of the following criteria are met: blasts < 15% in blood and bone marrow, peripheral blood basophils < 20%, platelets > 100 x 109/l.
Danish: CLM i kronisk fase defineres ved, at alle følgende kriterier er opfyldt: blaster <15 % i blod og knoglemarv, perifere blodbasofiltal <20%, trombocyttal > 100 x 109 /l.
English: Dosing in children and adolescents at 260 and 340 mg/m2/day achieved the same exposure, respectively, as doses of 400 mg and 600 mg in adult patients.
Danish: Doser på 260 og 340 mg/m2/dag til børn og unge gav samme optagelse som doser på henholdsvis 400 mg og 600 mg til voksne.
English: Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL).
Danish: - Hypereosinofil syndrom (HES) og/eller kronisk eosinofil leukæmi (CEL).
English: • adult and paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of treatment.
Danish: • voksne og børn med nydiagnosticeret Philadelphiakromosom (bcr-abl) positiv (Ph+) kronisk myeloid leukæmi (CML), for hvilke knoglemarvstransplantation ikke anses for førstevalgsbehandling.
English: However, the occurrence of cytopenias was also clearly dependent on the stage of the disease, the frequency of grade 3 or 4 neutropenias (ANC < 1.0x109/1) and thrombocytopenias (platelet count < 50x109/1) being between 4 and 6 times higher in blast crisis and accelerated phase (59-64% and 44-63% for neutropenia and thrombocytopenia, respectively) as compared to newly diagnosed patients in chronic phase CML (16.7% neutropenia and 8.9% thrombocytopenia).
Danish: Incidensen af cytopeni hang imidlertid også tydeligt sammen med sygdomsstadiet, idet hyppighed af 3. eller 4. grads neutropeni (ANC <1,0 x 109/l) og trombocytopeni (trombocyttal <50 x 109/l) var 4-6 gange højere ved blastkrise og accelereret fase (59-64% og 44-63% for henholdsvis neutropeni og trombopeni) end ved sammenligning med nydiagnosticerede patienter med kronisk fase CML (16,7% neutropeni og 8,9% trombocytopeni).
English: The safety and efficacy of imatinib in children and adolescents with MDS/MPD, DFSP and HES/CEL aged less than 18 years of age have not been established in clinical trials.
Danish: Imatinibs sikkerhed og virkning hos børn og unge under 18 år med MDS/MPD, DFSP og HES/CEL er ikke klarlagt i kliniske studier.
English: Talk to your doctor before taking Imatinib Accord: - if you have or have ever had a liver, kidney or heart problem.
Danish: Advarsler og forsigtighedsregler Kontakt lægen, før du tager Imatinib Accord: - hvis du har eller har haft lever-, nyre- eller hjerteproblemer.
English: • adult patients with advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL) with FIP1L1-PDGFRα rearrangement.
Danish: • voksne patienter med refraktært hypereosiniphil syndrom (HES) og/eller kronisk eosinofil leukæmi (CEL) med FIP1L1-PDGFR-omlejring.
English: Consolidation therapy Alternating chemotherapy course: high dose chemotherapy with MTX 1 g/m2 i.v.
Danish: Supplerende kemoterapi omgange: høj-dosis kemoterapi med MTX 1 g/m2 i.v.
English: Very common Nausea, diarrhoea, vomiting, dyspepsia, abdominal pain6 Common
Danish: Meget almindelig Kvalme, diarré, opkast, dyspepsi, abdominalsmerter6 Almindelig
English: (1 h), days 28-31, 35-38, 42-45; 6-MP 60 mg/ m2 oral, days 26-46
Danish: (1 time), dag 2831, 35-38, 42-45; 6-MP 60 mg/m2 oral, dag 26-46
English: Imatinib Accord 400 mg film-coated tablets are supplied in packs containing 10, 30, or 90 tablets, but these may not all be available in your country.
Danish: Imatinib Accord 400 mg filmovertrukne tabletter leveres i pakker, der indeholder 10, 30 eller 90 tabletter, men ikke alle pakningsstørrelser fås nødvendigvis i dit land.
English: • Adult and paediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) integrated with chemotherapy.
Danish: • voksne og børn patienter med nydiagnosticeret Philadelphiakromosom positiv akut lymfoblastær leukæmi (Ph+ ALL) integreret med kemoterapi.
English: There is very limited experience in children and adolescents with MDS/MPD, DFSP and HES/CEL.
Danish: Der er begrænset erfaring hos børn og unge med MDS/MPD, DFSP og HES/CEL.
English: (0.5 h), days 7, 8, 14, 15; CP 500 mg/ m2 i.v.
Danish: (0,5 time), dag 7, 8, 14, 15; CP 500 mg/m2 i.v.
English: The estimated rate of patients free of progression to accelerated phase or blast crisis at 84 months was significantly higher in the Imatinib arm compared to the IFN arm (92.5% versus 85.1%, p<0.001).
Danish: Den estimerede frekvens af patienter fri for progression til fremskreden fase eller blastkrise efter 84 måneder var signifikant højere i Imatinib-armen end i IFN-armen (92,5 % vs. 85,1 %, p<0,001.
English: Patients with renal dysfunction or on dialysis should be given the minimum recommended dose of 400 mg daily as starting dose.
Danish: Nedsat nyrefunktion: Patienter med nedsat nyrefunktion eller i dialyse bør gives den mindste anbefalede dosis på 400 mg dagligt som startdosis.
English: There was a significant increase in exposure to imatinib (the mean Cmaxand AUC of imatinib rose by 26% and 40%, respectively) in healthy subjects when it was co-administered with a single dose of ketoconazole (a CYP3A4 inhibitor).
Danish: Der sås signifikant øgning i følsomhed for imatinib (gennemsnitlig Cmax og AUC for imatinib steg med henholdsvis 26% og 40%) hos raske frivillige ved samtidig administration af enkeltdosis ketoconazol (en CYP3A4-hæmmer).
English: The dose of 340 mg/m2 daily is recommended for children and adolescents with chronic phase CML and advanced phase CML (not to exceed the total dose of 800 mg).
Danish: Der anbefales en dosering på 340 mg/m2 daglig til børn og unge med CML i kronisk fase og i fremskredne faser (må ikke overskride en total dosering på 800 mg).
English: Herpes zoster, herpes simplex, nasopharyngitis, pneumonia1, sinusitis,cellulitis, upper respiratory tract infection, influenza, urinary tract infection, gastroenteritis, sepsis
Danish: Herpes zoster, herpes simplex, nasopharyngitis, pneumoni1, sinuitis, cellulitis, infektioner i øvre luftveje, influenza, urinvejsinfektion, gastroenteritis, sepsis
English: If any of these apply to you, tell your doctor before taking Imatinib Accord.
Danish: Hvis noget af det ovenstående gælder for dig, skal du fortælle din læge det, før du tager Imatinib Accord.
English: (q 12 h), days 2-3, for 4 cycles
Danish: (q 12 timer), dag 2-3, i 4 cyklus
English: Imatinib Accord is a treatment for adults for:
Danish: Imatinib Accord anvendes til behandling af voksne med:
English: • Nausea, shortness of breath, irregular heartbeat, clouding of urine, tiredness and/or joint discomfort associated with abnormal laboratory test results (e.g. high potassium, uric acid and calcium levels and low phosphorous levels in the blood).
Danish: • Kvalme, åndenød, uregelmæssig hjerterytme (puls), uklar urin, træthed og/eller ubehag forbundet med abnorme resultater af laboratorieprøver (f.eks. højt indhold af kalium-, urinsyre og calcium i blodet og lavt indhold af fosfor i blodet).
English: Blood amylase increased * These types of reactions have been reported mainly from post-marketing experience with Imatinib.
Danish: * Denne type bivirkninger er hovedsageligt blevet rapporteret efter markedsføring af Imatinib.
English: There is limited experience in children and adolescents with Ph-positive ALL and very limited experience in children and adolescents with MDS/MPD, DFSP and HES/CEL.
Danish: Der er begrænset erfaring hos børn og unge og Phpositiv ALL og meget begrænset erfaring med børn og unge med MDS/MPD, DFSP og HEL/CEL.
English: 10 film-coated tablets 30 film-coated tablets 90 film-coated tablets 30x1 film-coated tablets 60x1 film-coated tablets 90x1 film-coated tablets
Danish: 10 filmovertrukne tabletter 30 filmovertrukne tabletter 90 filmovertrukne tabletter 30 x 1 filmovertrukne tabletter 60 x 1 filmovertrukne tabletter 90 x 1 filmovertrukne tabletter
English: In paediatric CML patients the most frequent toxicities observed were grade3 or 4 cytopenias involving neutropenia, thrombocytopenia and anaemia.
Danish: De hyppigst observerede alvorlige bivirkninger hos børn med CML var grad 3 eller 4 cytopenier med neutropeni, trombocytopeni og anæmi.
English: Posology for CML in children and adolescents
Danish: Dosering ved CML hos børn og unge
English: 20 film-coated tablets 60 film-coated tablets 120 film-coated tablets 180 film-coated tablets 30x1 film-coated tablets 60x1 film-coated tablets 90x1 film-coated tablets 120x1 film-coated tablets 180x1 film-coated tablets
Danish: 20 filmovertrukne tabletter 60 filmovertrukne tabletter 120 filmovertrukne tabletter 180 filmovertrukne tabletter 30 x 1 filmovertrukne tabletter 60 x 1 filmovertrukne tabletter 90 x 1 filmovertrukne tabletter 120 x 1 filmovertrukne tabletter 180 x 1 filmovertrukne tabletter
English: Hepatic function should be carefully monitored in circumstances where imatinib is combined with chemotherapy regimens also known to be associated with hepatic dysfunction (see section 4.5 and 4.8).
Danish: Nøje monitoring af leverfunktionen skal udføres i tilfælde, hvor imatinib kombineres med kemoterapiregimer, som også vides at være forbundet med leverdysfunktion (se pkt.
English: Your doctor may decide to increase the dose to 400 mg, to be taken as 4 tablets of 100 mg or one tablet of 400 mg once a day, depending on how you respond to treatment.
Danish: Din læge kan beslutte at øge dosis til 400 mg, som skal tages som 4 tabletter à 100 mg eller én tablet à 400 mg én gang daglig afhængig af, hvordan du responderer på behandlingen.
English: - Do not breast-feed during the treatment with Imatinib Accord.
Danish: - Du må ikke amme, mens du er i behandling med Imatinib Accord.
English: If this applies to you, tell your doctor without taking Imatinib Accord.
Danish: Hvis dette gælder for dig, skal du fortælle din læge det, før du tager Imatinib Accord.
English: Patients with Renal impairment should be given the minimum starting dose.
Danish: Der bør anvendes mindste startdosis til patienter med nedsat nyrefunktion.
English: Keep taking Imatinib Accord every day for as long as your doctor tells you.
Danish: Hvor længe skal du tage Imatinib Accord Bliv ved med at tage Imatinib Accord hver dag, så længe som din læge har foreskevet det.
English: Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF), PDGF-R, and inhibits PDGF-mediated cellular events.
Danish: Imatinib hæmmer også receptortyrosinkinaserne for trombocytafledte vækstfaktorer (PDGF), PDGF-R og PDGF-medierede cellulære signaler.