FrancophonIA/ELRC3.0 huggingface dataset:
English: 50 mg 25 kg to less than 50 kg 87.5 mg 50 kg or more
Slovenian: 50 mg 25 kg do manj kot 50 kg 87,5 mg 50 kg ali več
English: Study V continued for an additional 6 months with the abatacept and infliximab groups only.
Slovenian: Študija V se je nadaljevala dodatnih 6 mesecev le v skupinah, ki so prejemale abatacept ali infliksimab.
English: In vitro, abatacept attenuates human T lymphocyte activation as measured by decreased proliferation and cytokine production.
Slovenian: Abatacept in vitro zmanjša aktivacijo humanih limfocitov T, kar se kaže z manjšo proliferacijo in produkcijo citokinov.
English: To be administered as a 30-minute intravenous infusion at the dose specified in Table 1.
Slovenian: Zdravilo je treba aplicirati v obliki 30-minutne intravenske infuzije v odmerku, ki je naveden v preglednici 1.
English: • Please make sure you also have a list of all your other medicines with you at any visit to a health care professional.
Slovenian: • Pri vsakem obisku zdravnika imejte s seboj seznam vseh drugih zdravil, ki jih uporabljate.
English: Remove one Pen from the refrigerator and let it rest at room temperature (about 25°C) for 30 minutes.
Slovenian: Iz hladilnika vzemite en injekcijski peresnik in ga pustite 30 minut na sobni temperaturi (približno 25 °C).
English: Keep this card with you for 3 months after the last ORENCIA dose, since side effects may occur a long time after your last dose of ORENCIA.
Slovenian: To kartico imejte pri sebi še najmanj 3 mesece po uporabi zadnjega odmerka zdravila ORENCIA, saj se neželeni učinki lahko pojavijo še daljši čas po uporabi zadnjega odmerka.
English: If you have received ORENCIA while you were pregnant, it is important that you inform the baby's health care personnel before any vaccinations are given to your baby.
Slovenian: Če ste zdravilo ORENCIA prejeli med nosečnostjo, je pomembno, da o tem obvestite zdravstvene delavce, ki skrbijo za otroka, preden otrok prejme katero koli cepivo.
English: The safety and efficacy of subcutaneous abatacept were assessed in a single-arm, open-label study designed with a primary endpoint of steady-state trough concentration (cmin) at 4 months (short-term period) in the 6 to 17 year age cohort.
Slovenian: Varnost in učinkovitost subkutane uporabe abatacepta so vrednotili v enoskupinski, odprti študiji, katere primarni izid je bila najmanjša koncentracija (Cmin) v stanju dinamičnega ravnovesja po 4 mesecih (kratkoročno obdobje) v starostni kohorti 6 do 17 let.
English: You may notice a drop of fluid leaving the needle.
Slovenian: Morda boste opazili kapljico tekočine, ki izhaja iz igle.
English: In study SC-III, structural joint damage was assessed by MRI.
Slovenian: V študiji SC-III so strukturne poškodbe sklepa ocenili z magnetnoresonančnim slikanjem (MRI).
English: Patients with known malignancies were not included in these clinical trials.
Slovenian: V ta klinična preskušanja bolniki z znanimi novotvorbami niso bili vključeni.
English: e DAS28-CRP Remission is defined as a DAS28-CRP score < 2.6
Slovenian: e DAS28-CRP remisija je opredeljena kot ocena DAS28-CRP < 2,6
English: The most frequently reported adverse reactions (≥ 5%) among abatacept-treated patients were headache, nausea, and upper respiratory tract infections (including sinusitis).
Slovenian: Pri bolnikih, ki so prejemali abatacept, so najpogosteje (≥ 5%) poročali o glavobolu, slabosti in okužbah zgornjih dihal (vključno s sinuzitisom).
English: 1 silicone-free syringe
Slovenian: 1 injekcijska brizga brez silikona
English: Of the 219 patients entering the study, 56 (25.6%) had previously been treated with biologic DMARD therapy (including TNF inhibitors and tocilizumab).
Slovenian: Od 219 bolnikov, vključenih v študijo, se jih je 56 (25,6 %) predhodno zdravilo z biološkim DMARD zdravljenjem (vključno z zaviralci TNF in tocilizumabom).
English: The pre-filled syringe has a flange extender that makes it easier to hold and inject, and a needle guard that automatically covers the needle after a complete injection.
Slovenian: Napolnjena injekcijska brizga ima razširjeno držalo za prsta, kar olajša držanje in injiciranje zdravila in varovalo za iglo, ki po končanem injiciranju samodejno prekrije iglo.
English: Possible serious side effects include serious infections, malignancies (cancer) and allergic reactions, as listed below.
Slovenian: Kot je navedeno v nadaljevanju, možni resni neželeni učinki vključujejo hude okužbe, novotvorbe (rak) in alergijske reakcije.
English: Patients treated with abatacept subcutaneously also achieved similar ACR 50 and 70 responses as those patients receiving abatacept intravenously at 6 months.
Slovenian: Po 6 mesecih zdravljenja so bili pri bolnikih, ki so abatacept prejemali subkutano, doseženi tudi podobni odzivi ACR 50 in 70 kot pri bolnikih, ki so abatacept prejemali intravensko.
English: Study IV primarily assessed safety in patients with active rheumatoid arthritis requiring additional intervention in spite of current therapy with non-biological and/or biological DMARDs; all DMARDs used at enrollment were continued.
Slovenian: Študija IV je predvsem vrednotila varnost pri bolnikih z aktivnim revmatoidnim artritisom, ki so potrebovali dodatno ukrepanje kljub trenutnemu zdravljenju z nebiološkimi in/ali biološkimi imunomodulirajočimi protirevmatičnimi zdravili.
English: Their pJIA subtypes at disease onset were: oligoarticular (16%), polyarticular (64%; 20% of the total were rheumatoid factor positive), and systemic (20%).
Slovenian: Podtipi pJIA ob začetku bolezni so bili: oligoartikularni (16 %), poliartikularni (64 %; 20 % vseh je bilo pozitivnih na revmatoidni faktor) in sistemski (20 %).
English: Study SC-I compared the safety of abatacept including injection site reactions following subcutaneous or intravenous administration.
Slovenian: V študiji SC-I so primerjali varnost abatacepta, vključno z reakcijami na mestu injiciranja, po subkutani ali intravenski aplikaciji.
English: In the 6 to 17 year age cohort 132 (76.3%) patients completed 2 years.
Slovenian: V kohorti bolnikov, starih od 6 do 17 let, je 2-letno obdobje zaključilo 132 (76,3 %) bolnikov.
English: Tuberculosis (TB): You should be screened for TB prior to ORENCIA treatment.
Slovenian: Tuberkuloza (TBC): Pred začetkom zdravljenja z zdravilom ORENCIA je treba izvesti presejalno testiranje za tuberkulozo.
English: Studies indicate that naive T lymphocyte responses are more affected by abatacept than memory T lymphocyte responses.
Slovenian: Študije kažejo, da abatacept bolj vpliva na naivni T limfocitni odziv kot pa na spominski T limfocitni odziv.
English: Abatacept 125 mg SC N=213
Slovenian: Abatacept 125 mg s.c. N=213
English: Dates of ORENCIA Treatment:
Slovenian: Datum zdravljenja z zdravilom ORENCIA:
English: Of the 190 patients with pJIA treated with intravenous ORENCIA, one (0.5%) patient discontinued due to non-consecutive infusion reactions, consisting of bronchospasm and urticaria.
Slovenian: Od 190 bolnikov s pJIA, ki so se zdravili z zdravilom ORENCIA intravensko je bil en bolnik (0,5%) izključen iz študije zaradi infuzijske reakcije, ki je vključevala bronhospazem in urtikarijo in ni neposredno sledila infundiranju zdravila.
English: This medicine contains 34.5 mg sodium (main component of cooking/table salt) per maximum dose of 4 vials (8.625 mg sodium per vial).
Slovenian: To zdravilo vsebuje 34,5 mg natrija (glavne sestavine kuhinjske soli) na največji odmerek 4 viale (8,625 mg natrija na vialo).
English: The pharmacokinetics of abatacept is similar in adult RA and paediatric pJIA patients except for the higher SC absorption in pJIA patients.
Slovenian: Farmakokinetika abatacepta je pri odraslih bolnikih z RA in pri pediatričnih bolnikih s pJIA podobna, razen večje s.c. absorpcije pri bolnikih s pJIA.
English: • See the ORENCIA package leaflet for more information.
Slovenian: • Za več informacij glejte navodilo za uporabo zdravila ORENCIA.
English: The results were measured using the Genant-modified total Sharp score (TSS) and its components, the erosion score and joint space narrowing (JSN) score.
Slovenian: Rezultate so vrednotili na osnovi skupne Sharpove ocene, modificirane po Genantu (TSS - Genantmodified total Sharp score) in njenih komponent, ocene erozije in ocene zožitve sklepne špranje (JSN - joint space narrowing).
English: There is a theoretical concern that treatment with abatacept might increase the risk for autoimmune processes in adults and children, for example deterioration of multiple sclerosis.
Slovenian: Teoretično se pri zdravljenju z abataceptom lahko poveča tveganje za avtoimunske procese pri odraslih in otrocih, na primer poslabšanje multiple skleroze.
English: In the substudy of study VI, patients who had achieved remission at 2 years (DAS 28 ESR < 2.6) and after at least 1 year of treatment with abatacept in study VI were eligible to enter a substudy.
Slovenian: V podštudijo študije VI so bili vključeni bolniki, ki so glede na doseženo remisijo po 2 letih (DAS 28 sedimentacija eritrocitov < 2,6) in zdravljenje z abataceptom v študiji VI vsaj 1 leto, bili primerni za vključitev v podštudijo.
English: In study SC-I, abatacept was given subcutaneously to patients after a single loading dose of intravenous abatacept and then every week thereafter.
Slovenian: V študiji SC-I so bolniki abatacept prejeli subkutano po enkratnem začetnem intravenskem odmerku abatacepta, nato pa so ga prejemali enkrat na teden.
English: Dose-dependent reductions were observed with abatacept in serum levels of soluble interleukin2 receptor, a marker of T lymphocyte activation; serum interleukin-6, a product of activated synovial macrophages and fibroblast-like synoviocytes in rheumatoid arthritis; rheumatoid factor, an autoantibody produced by plasma cells; and C-reactive protein, an acute phase reactant of inflammation.
Slovenian: Opazili so od odmerka odvisno zmanjšanje topnega receptorja za interlevkin-2 v serumu, označevalca aktivacije limfocitov T; serumskega interlevkina-6, produkta aktiviranih sinovijskih makrofagov in fibroblastom podobnih sinoviocitov pri revmatoidnem artritisu; revmatoidnega faktorja, avtoprotiteles, ki jih proizvajajo plazmatke in C-reaktivnega proteina, reaktanta akutne faze vnetja.
English: ORENCIA is given to you into a vein, usually in your arm, over a period of 30 minutes.
Slovenian: Zdravilo ORENCIA boste prejeli v žilo, običajno v roko, v obliki 30 minutne infuzije.
English: After proper training in subcutaneous injection technique, a patient may self-inject with ORENCIA if a physician/healthcare professional determines that it is appropriate.
Slovenian: Po ustreznem usposabljanju iz tehnike subkutanega injiciranja si bolnik lahko zdravilo ORENCIA injicira sam, če zdravnik/zdravstveni delavec presodi, da je to primerno.
English: In patients assessed for anti-abatacept antibodies after discontinuation of abatacept (> 42 days after last dose), 103 of 1,888 (5.5%) were seropositive.
Slovenian: Pri bolnikih, ki so bili na protitelesa proti abataceptu preiskani po prekinitvi zdravljenja z abataceptom (> 42 dni po prejemu zadnjega odmerka), so seropozitivnost ugotovili pri 103 od 1.888 bolnikov (5,5%).
English: if you have had tuberculosis (TB) or have symptoms of tuberculosis (persistent cough, weight loss, listlessness, mild fever) tell your doctor.
Slovenian: če ste imeli tuberkulozo (TBC) ali imate simptome tuberkuloze (dolgotrajni kašelj, zmanjševanje telesne mase, ravnodušnost, rahlo zvišana telesna temperatura), to povejte svojemu zdravniku.
English: Unless they had discontinued due to safety reasons, all patients who completed, or had a flare during Period B or were non-responders in Period A were offered entry into Period C, the open-label extension, which assessed long-term safety and efficacy.
Slovenian: Če bolniki niso bili izključeni iz študije zaradi varnostnih razlogov, so bili vsi bolniki, ki so dokončali obdobje B študije ali se jim je bolezen med obdobjem B študije poslabšala ter bolniki brez odziva na zdravljenje v obdobju A študije, vključeni v obdobje C, odprto podaljšano fazo študije, ki je vrednotila dolgotrajno varnost in učinkovitost.
English: The active substance is abatacept.
Slovenian: Učinkovina je abatacept.
English: In rats, abatacept had no undesirable effects on male or female fertility (see section 5.3).
Slovenian: Pri podganah abatacept ni imel neželenih učinkov na plodnost samcev ali samic (glejte poglavje 5.3).
English: Psoriatic arthritis is an inflammatory disease of the joints, usually accompanied by psoriasis, an inflammatory disease of the skin.
Slovenian: Psoriazni artritis je vnetna bolezen sklepov, ki jo običajno spremlja psoriaza (luskavica), vnetna bolezen kože.
English: Study V: abatacept or infliximab versus placebo
Slovenian: Študija V: abatacept ali infliksimab v primerjavi s placebom
English: Population pharmacokinetic analyses did not detect any effect of methotrexate, NSAIDs, and corticosteroids on abatacept clearance (see section 5.2).
Slovenian: Pri analizah populacijske farmakokinetike učinkov metotreksata, nesteroidnih protivnetnih zdravil in kortikosteroidov na očistek abatacepta niso odkrili (glejte poglavje 5.2).
English: Studies I, II, III, V, and VI required patients to have at least 12 tender and 10 swollen joints at randomisation.
Slovenian: V študije I, II, III, V in VI so bili vključeni bolniki, ki so ob randomizaciji imeli vsaj 12 občutljivih in 10 oteklih sklepov.
English: Parenteral medicinal products containing maltose can interfere with the readings of blood glucose monitors that use test strips with glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ).
Slovenian: Zdravila za parenteralno uporabo, ki vsebujejo maltozo, lahko vplivajo na odčitke merjenja koncentracije krvnega sladkorja pri uporabi testnih lističev z glukoza dehidrogenaza pirolokinolinkinonom (GDH-PQQ).
English: Treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis or pJIA.
Slovenian: Zdravljenje mora uvesti in nadzirati zdravnik specialist, ki ima izkušnje z diagnosticiranjem in zdravljenjem revmatoidnega artritisa ali pJIA.
English: Check the liquid through the viewing window.
Slovenian: Preverite tekočino preko nadzornega okenca.
English: Allergic Reactions
Slovenian: Alergijske reakcije
English: The most frequently reported event with abatacept (1-2%) was dizziness.
Slovenian: Pri bolnikih, ki so prejemali abatacept, so najpogosteje (1-2 %) poročali o omotici.
English: There is a theoretical concern that treatment with abatacept might increase the risk for autoimmune processes in adults, for example deterioration of multiple sclerosis.
Slovenian: Teoretično se pri zdravljenju z abataceptom lahko poveča tveganje za avtoimunske procese pri odraslih, na primer poslabšanje multiple skleroze.
English: Needle Cover (ORANGE Cap)
Slovenian: Pokrovček igle (ORANŽNA zaporka)
English: Structural joint damage was assessed radiographically over a two-year period in studies II, and VI.
Slovenian: Strukturne poškodbe sklepa so vrednotili radiološko med dveletnim obdobjem v študiji II in v študiji VI.
English: A single study was conducted to determine the effect of monotherapy use of abatacept on immunogenicity following subcutaneous administration without an intravenous load.
Slovenian: Izvedena je bila ena študija za določitev učinka monoterapije z abataceptom na imunogenost po subkutani uporabi brez začetnega intravenskega odmerka.
English: In Period A all patients received 10 mg/kg of abatacept on days 1, 15, 29, 57 and 85 and were assessed on day 113.
Slovenian: V obdobju A so vsi bolniki prejeli abatacept v odmerku 10 mg/kg na 1., 15., 29., 57. in 85. dan in so bili nato ovrednoteni na 113. dan.
English: Talk to your doctor, pharmacist or nurse: if you experience allergic reactions such as chest tightness, wheezing, severe dizziness or lightheadedness, swelling or skin rash tell your doctor immediately.
Slovenian: Posvetujte se z zdravnikom, farmacevtom ali medicinsko sestro: če se pojavijo znaki alergijske reakcije, kot so stiskanje v prsih, težko dihanje, huda omotica ali vrtoglavica, oteklina ali kožni izpuščaj, to nemudoma povejte svojemu zdravniku.
English: Subjects continued taking their current dose of MTX from the day of randomisation.
Slovenian: Bolniki so od dneva randomizacije nadaljevali zdravljenje z MTX v trenutnem odmerku.
English: There were six overall discontinuations during this period, only one of which was due to an AE (the SAE of post-operative wound infection).
Slovenian: V celoti je bilo v tem obdobju iz študije izključenih 6 bolnikov, od tega le eden zaradi neželenega učinka (resen neželeni učinek pooperativne okužbe rane).
English: Women of childbearing potential have to use effective contraception during treatment and up to 14 weeks after the last dose of abatacept.
Slovenian: Ženske v rodni dobi morajo uporabljati učinkovito kontracepcijo med zdravljenjem in do 14 tednov po prejemu zadnjega odmerka abatacepta.
English: In SC-III the safety profiles of the three treatment groups (abatacept + MTX, abatacept monotherapy, MTX group) were overall similar.
Slovenian: V študiji SC-III so bili profili varnosti v treh skupinah zdravljenja (abatacept + MTX, monoterapija z abataceptom, skupina z MTX) na splošno podobni.
English: This means that before ORENCIA is given to you, it is first dissolved in water for injections, then further diluted with sodium chloride 9 mg/mL (0.9%) solution for injection.
Slovenian: To pomeni, da bodo zdravilo ORENCIA preden ga boste prejeli, najprej raztopili v vodi za injekcije in nato še nadalje razredčili z 0,9% raztopino natrijevega klorida za injekcije (9 mg/ml).
English: If you stop using ORENCIA The decision to stop using ORENCIA should be discussed with your doctor.
Slovenian: Če ste prenehali uporabljati zdravilo ORENCIA O prekinitvi zdravljenja z zdravilom ORENCIA se morate posvetovati s svojim zdravnikom.
English: Vial (15 mL Type 1 glass) with a stopper (halobutyl-rubber) and flip off seal (aluminium).
Slovenian: Viala (15 ml iz stekla tipa 1) z zamaškom (halobutilna guma) in dvižno zaporko (aluminij).
English: Treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis.
Slovenian: Zdravljenje mora uvesti in nadzirati zdravnik specialist, ki ima izkušnje z diagnosticiranjem in zdravljenjem revmatoidnega artritisa.
English: Step 3: Check the Dose on the Pre-filled Syringe Hold the syringe at eye level.
Slovenian: 3. korak: Preverite odmerek v napolnjeni injekcijski brizgi Injekcijsko brizgo držite v višini oči.
English: EU/1/07/389/002 2 vials and 2 silicone-free syringes (2 packs of 1) EU/1/07/389/003 3 vials and 3 silicone-free syringes (3 packs of 1)
Slovenian: EU/1/07/389/002 2 viali in 2 injekcijski brizgi brez silikona (2 pakiranji po 1) EU/1/07/389/003 3 viale in 3 injekcijske brizge brez silikona (3 pakiranja po 1)
English: c Patients who had less than 20% improvement in tender or swollen joint counts at Week 16 met escape criteria and were considered non-responders.
Slovenian: c Bolniki, pri katerih se število občutljivih ali oteklih sklepov v 16. tednu ni zmanjšalo vsaj za 20%, so izpolnili kriterije za izključitev in so bili obravnavani kot bolniki brez odziva.
English: Doses up to 50 mg/kg have been administered intravenously without apparent toxic effect.
Slovenian: Uporabljeni so bili intravenski odmerki do 50 mg/kg brez očitnih toksičnih učinkov.
English: If you received ORENCIA during your pregnancy, your baby may have a higher risk for getting an infection.
Slovenian: Če ste zdravilo ORENCIA prejeli med nosečnostjo, se pri otroku lahko poveča tveganje za pojav okužbe.
English: Abatacept decreases antigen specific TNFα, interferon-γ, and interleukin-2 production by T lymphocytes.
Slovenian: Abatacept zmanjša T limfocitno produkcijo antigensko specifičnega TNFα, interferona-γ in interlevkina-2.
English: The presence of antibodies was not associated with adverse reactions or infusion reactions, or with changes in efficacy or serum abatacept concentrations.
Slovenian: Prisotnost protiteles ni bila povezana niti s pojavom neželenih učinkov ali infuzijskih reakcij niti s spremembami učinkovitosti ali spremembami v serumskih koncentracijah abatacepta.
English: ORENCIA should not be infused concomitantly in the same intravenous line with other medicinal products.
Slovenian: Zdravila ORENCIA se ne sme infundirati sočasno z drugimi zdravili preko iste intravenske linije.
English: If needed, you may apply a small adhesive plaster to the injection site.
Slovenian: Po potrebi lahko na mesto injiciranja namestite manjši samolepilni obliž.
English: The patients entered in the trial were a mean of 12.4 years of age with mean disease duration of 4.4 years.
Slovenian: Bolniki, ki so bili vključeni v preskušanje, so bili v povprečju stari 12,4 let, bolezen pa je v povprečju trajala 4,4 leta.
English: Following the initial administration, ORENCIA should be given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter.
Slovenian: Po začetni aplikaciji mora bolnik zdravilo ORENCIA prejeti 2 in 4 tedne po prvem infundiranju, nato pa na vsake 4 tedne.
English: Mean steady-state trough concentrations were approximately 25 mcg/mL, and mean Cmax concentrations were approximately 290 mcg/mL.
Slovenian: Povprečne najmanjše koncentracije v stanju dinamičnega ravnovesja so bile približno 25 μg/ml, povprečne Cmax koncentracije pa približno 290 μg/ml.
English: Combination with TNF-inhibitors
Slovenian: Kombinacija z zaviralci TNF
English: Inspect the syringe for obvious flaws, but don't remove the needle cover.
Slovenian: Preverite, če je injekcijska brizga kakor koli očitno poškodovana, vendar pa pri tem pokrovčka igle ne smete odstraniti.
English: The recommended dose of abatacept for adults with rheumatoid arthritis or psoriatic arthritis is based on body weight:
Slovenian: Priporočeni odmerek abatacepta za odrasle z revmatoidnim artritisom ali s psoriaznim artritisom je odvisen od telesne mase:
English: If you miss your dose by more than three days, ask your doctor when to take your next dose.
Slovenian: Če ste izpustili odmerek za več kot tri dni, se o uporabi naslednjega odmerka posvetujte s svojim zdravnikom.
English: No physical or biochemical compatibility studies have been conducted to evaluate the co-administration of ORENCIA with other medicines.
Slovenian: Študije fizikalne in biokemične stabilnosti pri sočasni aplikaciji zdravila ORENCIA in drugih zdravil niso bile izvedene.
English: For children and adolescents aged 6 to 17 years with polyarticular juvenile idiopathic arthritis who weigh less than 75 kg, the recommended dose of intravenous abatacept is 10 mg/kg.
Slovenian: Za otroke in mladostnike, stare od 6 do 17 let, s poliartikularnim juvenilnim idiopatskim artritisom s telesno maso, manjšo od 75 kg, je priporočeni intravenski odmerek abatacepta 10 mg/kg.
English: Abatacept is produced by recombinant DNA technology in Chinese hamster ovary cells.
Slovenian: Abatacept je pridobljen s tehnologijo rekombinantne DNA na ovarijskih celicah kitajskega hrčka.
English: However, if you are feeling tired or unwell after receiving ORENCIA, you should not drive, cycle or operate any machinery.
Slovenian: Kljub temu pa v primeru, da se po prejemu zdravila ORENCIA počutite utrujeni ali se slabo počutite, ne smete voziti vozil, kolesariti ali upravljati strojev.
English: Clinical responses in controlled trials Percent of patients
Slovenian: Preglednica 3: Klinični odzivi v nadzorovanih preskušanjih Odstotek bolnikov
English: Abatacept is a fusion protein produced by recombinant DNA technology in Chinese hamster ovary cells.
Slovenian: Abatacept je fuzijski protein, pridobljen s tehnologijo rekombinantne DNA na ovarijskih celicah kitajskega hrčka.
English: In those patients who initially received infliximab and then switched to abatacept, the reduction in the mean DAS28 score from baseline was 3.29 at day 729 and 2.48 at day 365.
Slovenian: Pri bolnikih, ki so v začetku prejemali infliksimab in so nato prešli na zdravljenje z abataceptom, je zmanjšanje povprečne vrednosti DAS28 od izhodišča na 729. dan znašalo 3,29, na 365. dan pa 2,48.
English: You will hear a click as the injection begins.
Slovenian: Ob začetku injiciranja boste zaslišali klik.