FrancophonIA/ELRC3.0 huggingface dataset:
English: Qutenza cutaneous patch: Store flat in the original sachet and carton.
Croatian: Qutenza naljepak za kožu: čuvati u vodoravnom položaju u originalnoj vrećici i kutiji.
English: Overdose may be associated with severe application site reactions, e.g. application site pain, application site erythema, application site pruritus.
Croatian: Predoziranje može biti povezano s teškim reakcijama na mjestu primjene, npr., bolom na mjestu primjene, eritemom na mjestu primjene i svrbežom na mjestu primjene.
English: The treatment area may be pre-treated with a topical anaesthetic or the patient may be administered an oral analgesic prior to application of Qutenza to reduce potential application related discomfort.
Croatian: Prije primjene Qutenze, na područje liječenja može se nanijeti topikalni anestetik ili se bolesniku može dati oralni analgetik da bi se smanjila moguća nelagoda povezana s primjenom naljepka.
English: macrogol 300 carbomer purified water sodium hydroxide (E524) disodium edetate butylhydroxyanisole (E320)
Croatian: makrogol 300 karbomer pročišćena voda natrijev hidroksid (E524) dinatrijev edetat butilhidroksianizol (E320)
English: Reductions in sensory function have been reported following administration of Qutenza.
Croatian: Nakon primjene Qutenze, bila su prijavljena smanjenja osjetilne funkcije.
English: Therefore, overdosing is unlikely to occur.
Croatian: Stoga je vjerojatnost da će doći do predoziranja mala.
English: Each Qutenza carton contains 1 or 2 sachets and 1 tube of cleansing gel (50 g).
Croatian: Jedna kutija Qutenze sadrži 1 ili 2 vrećice i 1 tubu gela za čišćenje (50 g).
English: The release liner should NOT be removed until just prior to application.
Croatian: Zaštitnu foliju NE smije se ukloniti sve do neposredne primjene.
English: How to use Qutenza
Croatian: Kako primjenjivati Qutenzu
English: Cleansing gel macrogol 300 carbomer purified water sodium hydroxide (E524) disodium edetate butylhydroxyanisole (E320)
Croatian: Gel za čišćenje makrogol 300 karbomer pročišćena voda natrijev hidroksid (E524) dinatrijev edetat butilhidroksianizol (E320)
English: After the cleansing gel has been wiped off, the area should be gently washed with soap and water.
Croatian: Nakon što je gel za čišćenje obrisan, to područje treba nježno isprati vodom i sapunom.
English: 2 sachets, each containing 1 cutaneous patch and 1 tube of cleansing gel (50 g).
Croatian: 2 vrećice, svaka s 1 naljepkom za kožu, i 1 tuba gela za čišćenje (50 g).
English: Cutaneous use only.
Croatian: Qutenzu smije primjenjivati samo
English: 1 sachet containing 1 cutaneous patch and 1 tube of cleansing gel (50 g).
Croatian: 1 vrećica s 1 naljepkom za kožu i 1 tuba gela za čišćenje (50 g).
English: Cut patch to match treatment area size.
Croatian: Izrežite naljepak tako da veličinom odgovara području liječenja.
English: Nervous system disorders Common
Croatian: Poremećaji živčanog sustava Često osjećaj žarenja
English: There is a diagonal cut in the release liner to aid in its removal.
Croatian: Na zaštitnoj je foliji dijagonalni urez koji olakšava njezino uklanjanje.
English: Appropriate medical care should be provided if shortness of breath develops.
Croatian: Ako nastupi nedostatak zraka, potrebno je primijeniti odgovarajuću medicinsku skrb.
English: Store flat in the original sachet and carton.
Croatian: Čuvati u vodoravnom položaju u originalnoj vrećici i kutiji.
English: Remove patch release liner and apply to the skin.
Croatian: Uklonite zaštitnu foliju naljepka i stavite naljepak na kožu.
English: In Table 1 below all adverse reactions, which occurred at an incidence greater than control and in more than one patient in controlled clinical trials in patients with postherpetic neuralgia (PHN), painful Human Imunodeficiency Virus - Associated Neuropathy (HIV-AN) and painful diabetic peripheral neuropathy, are listed by system organ class and frequency: very common (≥ 1/10), common (≥ 1/100
Croatian: U tablici 1 niže, sve nuspojave koje su se pojavile incidencijom većom od one uz kontrolu i u više od jednog bolesnika u kontroliranim kliničkim ispitivanjima u bolesnika s postherpetičnom neuralgijom (eng. postherpetic neuralgia - PHN), bolnom neuropatijom povezanom s HIV-om (eng.
English: SACHET OF ONE PATCH
Croatian: VREĆICA S JEDNIM NALJEPKOM
English: The patch should be held in place.
Croatian: Naljepak treba pritisnuti na mjesto primjene.
English: Cough, throat irritation
Croatian: Manje često kašalj, nadraženost grla
English: OTHER SPECIAL WARNING, IF NECESSARY
Croatian: OD LIJEKA, AKO JE POTREBNO
English: Dermal assessment
Croatian: Način primjene
English: Backing layer
Croatian: Tablični prikaz nuspojava
English: Infections and infestations Uncommon
Croatian: Infekcije i infestacije Manje često herpes zoster
English: Eye disorders Uncommon
Croatian: Poremećaj oka Manje često nadraženost oka
English: Qutenza should only be applied by your doctor or by a nurse under the supervision of your doctor.
Croatian: Vaš liječnik ili medicinska sestra pod nadzorom liječnika.
English: STADA Poland Sp. Z.o o. Tel.: +48 227377920
Croatian: Tel.: +48 227377920
English: Application site pruritus, application site papules, application site vesicles, application site oedema, application site swelling, application site dryness
Croatian: Često svrbež na mjestu primjene, papule na mjestu primjene, vezikule na mjestu primjene, edem na mjestu primjene, otečenost na mjestu primjene, suhoća na mjestu primjene
English: Outline treatment area.
Croatian: Odredite rubove područja liječenja.
English: Disposable socks may be worn on top of the Qutenza patches if your feet are being treated.
Croatian: Ako naljepcima Qutenza liječite stopala, možete preko njih nositi čarape za jednokratnu uporabu.
English: Not known
Croatian: Prije nego
English: • If you get any side effects talk to your doctor.
Croatian: • Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika.
English: Fycompa is taken by mouth once a day at bedtime.
Croatian: Fycompa se uzima na usta jednom na dan u vrijeme odlaska na počinak.
English: Secondary generalisation occurs when the excessive electrical activity subsequently reaches the whole brain.
Croatian: Sekundarna generalizacija nastupa kada prekomjerna električna aktivnost posljedično proširi na cijeli mozak.
English: Fycompa oral suspension can be taken with or without food and should always be taken in the same way (i.e. always with food or always without food).
Croatian: Fycompa oralna suspenzija može se uzimati s hranom ili bez nje te se mora uvijek uzimati na isti način (tj. uvijek s hranom ili uvijek bez hrane).
English: All patients were also taking other antiepileptic medicines.
Croatian: Svi bolesnici su također uzimali druge lijekove protiv epilepsije.
English: This is a type of epilepsy where too much electrical activity in one part of the brain causes symptoms such as sudden, jerky movements of one part of the body, distorted hearing, sense of smell or vision, numbness or a sudden sense of fear.
Croatian: To je vrsta epilepsije kod koje pretjerana električna aktivnost u jednom dijelu mozga uzrokuje simptome kao što su iznenadni trzaji jednog dijela tijela, smetnje sluha, njuha ili vida, otupljenost ili iznenadni osjećaj straha.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Fycompa on 23 July 2012.
Croatian: Europska komisija izdala je odobrenje za stavljanje u promet koje je za lijek Fycompa na snazi u Europskoj uniji od 23. srpnja 2012.
English: It is available as tablets (2, 4, 6, 8, 10 and 12 mg) and as an oral suspension (0.5 mg/ml, to be taken by mouth).
Croatian: Dostupan je u obliku tableta (2, 4, 6, 8, 10 i 12 mg) te kao oralna suspenzija (0,5 mg/ml).
English: Glutamate is the main stimulatory neurotransmitter in nerve cells which can trigger and maintain seizures.
Croatian: Glutamat je glavni stimulirajući neurotransmiter u živčanim stanicama koji može potaknuti i održavati napade.
English: Neurotransmitters are naturally-occurring chemicals in the nervous system that allow nerve cells to communicate with each other.
Croatian: Neurotransmiteri su kemikalije u živčanom sustavu koje se prirodno pojavljuju i omogućavaju međusobnu komunikaciju živčanih stanica.
English: Fycompa tablets can be taken with or without food and should not be chewed, crushed or split.
Croatian: Fycompa tablete mogu se uzimati s hranom ili bez nje te ih se ne smije gristi, žvakati niti komadati.
English: What measures are being taken to ensure the safe and effective use of Fycompa?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Fycompa?
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Fycompa.
Croatian: Objašnjava kako je Odbor za lijekove za humanu uporabu (CHMP) ocijenio lijek da bi donio svoje mišljenje u korist davanja odobrenja za stavljanje lijeka u promet i svoje preporuke za primjenu lijeka Fycompa.
English: This is a summary of the European public assessment report (EPAR) for Fycompa.
Croatian: Ovo je sažetak europskoga javnog izvješća o ocjeni dokumentacije (EPAR) o lijeku Fycompa.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Fycompa have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Fycompa nalaze se u sažetku opisa svojstava lijeka i u uputi o lijeku.
English: The dose should not exceed 8 mg per day in patients with mildly or moderately reduced liver function.
Croatian: Doza ne smije premašiti 8 mg na dan u bolesnika s blagom do umjereno smanjenom funkcijom jetre.
English: The main measure of effectiveness was the percentage of patients who experienced at least a 50% decrease in seizure frequency.
Croatian: Glavna mjera djelotvornosti bio je postotak bolesnika koji su iskusili najmanje 50% smanjenje u učestalosti napada.
English: The recommended dose at the start of treatment is 2 mg per day, and if it is well tolerated the doctor may progressively increase it by increments of 2 mg/day to a maximum dose of 12 mg per day.
Croatian: Preporučena doza na početku terapije je 2 mg na dan, a ako se dobro podnosi, liječnik može progresivno povećati dozu po 2 mg na dan do maksimalne doze od 12 mg na dan.
English: Although the precise mechanism by which Fycompa works is not fully understood, it is thought to block the action of the neurotransmitter glutamate.
Croatian: Iako točan mehanizam djelovanja lijeka Fycompa nije u potpunosti poznat, smatra se da inhibira djelovanje neurotransmitera glutamata.
English: In these studies, Fycompa was given at a dose of 2, 4, 8 or 12 mg per day for up to 19 weeks.
Croatian: U tim je ispitivanjima Fycompa primijenjen u dozi od 2, 4, 8 ili 12 mg na dan tijekom 19 tjedana.
English: Other information about Fycompa
Croatian: Ostale informacije o lijeku Fycompa
English: Fycompa must only be used as an ‘add-on' therapy to other anti-epileptic medicines.
Croatian: Fycompa se smije koristiti samo kao „dodatna” terapija drugim lijekovima protiv epilepsije.
English: Fycompa is also used in patients from 12 years of age to treat primary generalised tonic-clonic seizures (major fits or convulsions, where the person becomes unconscious, falls down if standing, and jerks or shakes) associated with idiopathic generalised epilepsy (epilepsy with no apparent cause that is thought to have a genetic origin and that affects the whole brain).
Croatian: Fycompa se također koristi u bolesnika u dobi iznad 12 godina za liječenje primarno generaliziranih toničko-kloničkih napada (većih napada ili konvulzija kada osoba izgubi svijest, padne dok stoji te se trza ili trese) povezanih s idiopatskom generaliziranom epilepsijom (epilepsijom bez očitog uzroka za koju se smatra da ima genetsko porijeklo te da zahvaća cijeli mozak).
English: The most common side effects with Fycompa (seen in more than 1 patient in 10) are dizziness and somnolence (sleepiness).
Croatian: Najčešće nuspojave lijeka Fycompa (koje se mogu javiti u više od 1 na 10 osoba) su vrtoglavica i somnolencija (pospanost).
English: For primary generalised tonic-clonic seizures Fycompa was shown to be effective in a study involving 164 patients with idiopathic generalised epilepsy.
Croatian: U slučaju primarno generaliziranih toničko-kloničkih napada, utvrđeno je da je Fycompa djelotvoran u ispitivanju koje je obuhvatilo 164 bolesnika s idiopatskom generaliziranom epilepsijom.
English: In the management of partial onset seizures, Fycompa has been compared with placebo (a dummy treatment) in three main studies involving a total of 1,491 patients aged 12 years and older with partial-onset seizures who did not respond to other treatments.
Croatian: U kontroli parcijalnih napada Fycompa je uspoređen s placebom (prividnim liječenjem) u tri glavna ispitivanja koja su obuhvatila ukupno 1491 bolesnika u dobi od 12 godina i starijih s parcijalnim napadima koji nisu reagirali na druge terapije.
English: Fycompa is used to treat adults and children from 12 years of age with partial-onset seizures (epileptic fits) with or without secondary generalisation.
Croatian: Fycompa se koristi za terapiju odraslih osoba i adolescenata u dobi iznad 12 godina s parcijalnim napadima (epileptičnim napadima) sa sekundarnom generalizacijom ili bez nje.
English: Supportive evidence from patients treated for up to 2 years suggested that the benefit was maintained with longer treatment and that some patients could benefit from doses up to 12 mg.
Croatian: Dokazi koji govore tome u prilog prikupljeni od bolesnika liječenih do 2 godine ukazuju dulje održavanje pozitivnih učinaka s duljom terapijom te da bi pojedini bolesnici mogli imati koristi od povećanja doze na 12 mg.
English: Treatment was started at a dose of 2 mg of Fycompa and gradually increased over 4 weeks to a maximum of 8 mg if tolerated, then continued for a further 13 weeks.
Croatian: Terapija je započeta u dozi od 2 mg lijeka Fycompa i postupno je povećavana tijekom 4 tjedna do maksimalne doze od 8 mg ako je lijek dobro podnošen, te je zatim terapija nastavljena tijekom daljnjih 13 tjedana.
English: Fycompa at doses from 4 mg to 12 mg was shown to be more effective than placebo in reducing the frequency of epileptic seizures.
Croatian: Utvrđeno je kako je lijek Fycompa u dozi od 4 mg do 12 mg djelotvorniji od placeba u smanjivanju učestalosti epileptičnih napada.
English: The full EPAR for Fycompa can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Croatian: Cjeloviti EPAR za lijek Fycompa nalazi se na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports Više informacija o terapiji lijekom Fycompa pročitajte u uputi o lijeku (također dio EPAR-a) ili se obratite svom liječniku ili ljekarniku.
English: What is Fycompa?
Croatian: Što je Fycompa?
English: Fycompa was compared with placebo as an addition to patients' existing epilepsy treatment.
Croatian: Fycompa je uspoređen s placebom kao dodatak postojećoj terapiji za epilepsiju u bolesnika.
English: Why has Fycompa been approved?
Croatian: Zašto je Fycompa odobren?
English: The third study showed a significant decrease in seizure frequency only in patients taking 4 mg and 8 mg Fycompa but not in patients taking a dose of 2 mg.
Croatian: U trećem ispitivanju utvrđeno je značajno smanjenje učestalosti napada samo u bolesnika koji su uzimali 4 mg i 8 mg lijeka Fycompa, no ne i u bolesnika koji su uzimali 2 mg.
English: What is the risk associated with Fycompa?
Croatian: Koji se rizici povezuju s lijekom Fycompa?
English: In the second study, 33.3% and 33.9% of patients taking 8 mg and 12 mg Fycompa respectively showed a decrease in seizure frequency of at least 50%, compared with 14.7% of patients taking placebo.
Croatian: U drugom ispitivanju, 33,3 % i 33,9 % bolesnika koji su uzimali 8 mg i 12 mg lijeka Fycompa pokazalo je smanjenje u učestalosti napada od najmanje 50 %, u usporedbi s 14,7 % bolesnika koji su uzimali placebo.
English: Fycompa is a medicine that contains the active substance perampanel.
Croatian: Fycompa je lijek koji sadrži djelatnu tvar perampanel.
English: Therefore, the CHMP decided that Fycompa's benefits are greater than its risks and recommended that it be given marketing authorisation.
Croatian: CHMP je odlučio da koristi od lijeka Fycompa nadmašuju s njim povezane rizike te je preporučio izdavanje odobrenja za stavljanje lijeka u promet.
English: For patients with primary generalised tonic-clonic seizures Fycompa was also more effective than placebo: 47 of 81 patients (58%) given Fycompa had at least a 50% reduction in frequency of seizures, compared with 29 of 81 (36%) of those given the dummy treatment.
Croatian: U slučaju bolesnika s primarno generaliziranim toničko-kloničkim napadima, lijek Fycompa bio je djelotvorniji od placeba: 47 od 81 bolesnika (58 %) koji su primili lijek Fycompa imalo je smanjenje od najmanje 50 % u učestalosti napada, u usporedbi s 29 od 81 (36 %) u bolesnika koji su primili prividno liječenje.
English: The CHMP considered that Fycompa, taken together with other anti-epileptic medicines, showed a consistent reduction in the frequency of epileptic fits and that no serious toxicity has been identified.
Croatian: CHMP je zaključio da je Fycompa pokazao kontinuirano smanjenje učestalosti epileptičnih napada te da nije utvrđena ozbiljna toksičnost ako se uzima zajedno s drugim lijekovima protiv epilepsije.
English: Therefore by blocking glutamate's actions, Fycompa is thought to stop epileptic seizures from occurring.
Croatian: Stoga se smatra da inhibirajući djelovanje glutamata, Fycompa sprječava nastup epileptičnih napada.
English: In the first study, the percentage of patients who experienced a decrease in seizure frequency of at least 50% was 37.6% for patients taking 8 mg Fycompa and 36.1% for patients taking 12 mg Fycompa, compared with 26.4% of patients taking placebo.
Croatian: U prvom ispitivanju postotak bolesnika koji je iskusio smanjenje učestalosti napada od najmanje 50 % bio je 37,6 % za bolesnike koji su uzimali 8 mg lijeka Fycompa i 36,1 % za bolesnike koji su uzimali 12 mg lijeka Fycompa, u usporedbi s 26,4 % bolesnika koji su uzimali placebo.
English: The active substance in Fycompa, perampanel, is an anti-epileptic medicine.
Croatian: Djelatna tvar u lijeku Fycompa, perampanel, lijek je protiv epilepsije.
English: What is Fycompa used for?
Croatian: Za što se Fycompa koristi?
English: What benefit has Fycompa shown during the studies?
Croatian: Koje su koristi lijeka Fycompa utvrđene tijekom ispitivanja?
English: How is Fycompa used?
Croatian: Kako se Fycompa koristi?
English: How has Fycompa been studied?
Croatian: Kako je Fycompa ispitivan?
English: For the full list of all side effects and restrictions with Fycompa, see the package leaflet.
Croatian: Potpuni popis nuspojava zabilježenih pri primjeni lijeka Fycompa potražite u uputi o lijeku.
English: How does Fycompa work?
Croatian: Kako djeluje Fycompa?
English: You and your child may need to read it again.
Croatian: Možda ćete je Vi i Vaše dijete trebati ponovno pročitati.
English: Blank white foil without any printed information.
Croatian: Prazna bijela folija bez tiskanih informacija.
English: 1 produced in Vero cells
Croatian: 1 proizveden na Vero stanicama
English: If the vaccine has been frozen it should not be used.
Croatian: Ako je cjepivo bilo zamrznuto, ne smije se koristiti.
English: The pre-filled syringe is for single use only and should not be used for more than one person.
Croatian: Napunjena štrcaljka namijenjena je samo za jednokratnu uporabu i ne smije se koristiti za više od jedne osobe.
English: It is currently difficult to explain if this phenomenon is treatment related or not.
Croatian: Trenutno je teško objasniti ima li ovaj fenomen veze s liječenjem.
English: Many infected people develop mild symptoms or no symptoms at all.
Croatian: Mnogi zaraženi ljudi razviju blage simptome ili ne razviju nikakve simptome.
English: Non-clinical toxicity data are limited.
Croatian: Neklinički podaci o toksičnosti su ograničeni.
English: In this case, your doctor will postpone the vaccination.
Croatian: U tom slučaju, Vaš će liječnik odgoditi cijepljenje.
English: Mathematical modelling was applied to project the average duration of protection.
Croatian: Primijenjen je matematički model za projiciranje prosječnog trajanja zaštite.
English: The vaccine causes the body to produce its own protection (antibodies) against this disease.
Croatian: Cjepivo potiče tijelo da stvori vlastitu zaštitu (protutijela) protiv ove bolesti.
English: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Croatian: U nedostatku ispitivanja kompatibilnosti, ovaj se lijek ne smije miješati s drugim lijekovima.
English: This vaccine has been prescribed for you and/or your child only.
Croatian: • Ovo je cjepivo propisano samo za Vas i/ili Vaše dijete.
English: Risk Management Plan (RMP)
Croatian: PRIMJENU LIJEKA Plan upravljanja rizikom (RMP)
English: For adjuvant, see section 2.
Croatian: Za adjuvanse vidjeti dio 2.
English: Ask your pharmacist how to throw away medicines you and/or your child no longer use.
Croatian: Pitajte ljekarnika kako baciti lijekove koje Vi i/ili Vaše dijete više ne koristite.
English: If you have any further questions, ask your doctor.
Croatian: • Ako imate dodatnih pitanja, obratite se svom liječniku.
English: If a needle is not provided, use a sterile needle.
Croatian: Ako igla nije priložena, koristite sterilnu iglu.
English: This virus is mainly found in Asia and is transmitted to humans by mosquitoes that have bitten an infected animal (like pigs).
Croatian: Ovaj se virus uglavnom nalazi u Aziji i na ljude se prenosi ubodom komaraca koji su prethodno uboli zaražene životinje (poput svinje).
English: A-1030 Vienna
Croatian: A-1030 Beč
English: No prospective efficacy trials have been performed.
Croatian: Nisu provedena prospektivna ispitivanja djelotvornosti.
English: Do not throw away any medicines via wastewater or household waste.
Croatian: • Nikada nemojte nikakve lijekove bacati u otpadne vode ili u kućni otpad.
English: If the primary immunization of two injections is not completed, full protection against the disease might not be achieved.
Croatian: Ako se ne dovrši primarna imunizacija s dvije injekcije, možda se neće postići potpuna zaštita od bolesti.
English: Contents of the pack and other information What IXIARO contains
Croatian: Sadržaj pakiranja i druge informacije Što IXIARO sadrži
English: Tell your doctor if you and/or your child are taking or have recently taken, or might take any other medicines, including medicines obtained without a prescription or have recently received any other vaccine.
Croatian: Obavijestite svog liječnika ako Vi i/ili Vaše dijete uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući i one koje ste nabavili bez recepta ili ako ste nedavno primili bilo koje drugo cjepivo.
English: For elderly persons (>65 years) the first booster dose may be given earlier.
Croatian: Starijim osobama (> 65 godina) prva doza za docjepljivanje može se dati ranije.
English: The majority of the side effects listed below have been observed during clinical trials.
Croatian: Većina nuspojava navedenih u nastavku uočena je tijekom kliničkih ispitivanja.
English: In patients receiving immunosuppressive therapy or patients with immunodeficiency an adequate immune response may not be obtained.
Croatian: U bolesnika koji primaju imunosupresivnu terapiju ili bolesnika s imunodeficijencijom možda se neće postići adekvatan imunološki odgovor.
English: In animal studies findings of unclear clinical relevance have been identified (see section 5.3).
Croatian: U ispitivanjima na životinjama dobiveni su nalazi nejasnog kliničkog značaja (vidjeti dio 5.3).
English: No symptoms related to overdose were reported.
Croatian: Nisu prijavljeni simptomi koji se odnose na predoziranje.