FrancophonIA/ELRC3.0 huggingface dataset:
English: - Your doctor has prescribed lopinavir/ritonavir to help to control your Human Immunodeficiency Virus (HIV) infection.
Croatian: Liječnik Vam je propisao lopinavir/ritonavir kako bi Vam pomogao u kontroli infekcije virusom humane imunodeficijencije (HIV; engl.
English: For infants and young children unable to swallow tablets, more suitable formulations containing lopinavir/ritonavir should be checked for their availability.
Croatian: Za dojenčad i malu djecu koja ne mogu progutati tablete treba provjeriti dostupnost prikladnijih forumlacija koje sadrže lopinavir/ritonavir.
English: Patients with advanced HIV disease may be at risk of elevated triglycerides and pancreatitis.
Croatian: U bolesnika s uznapredovalom HIV bolešću može se povećati rizik od povišene razine triglicerida i od pankreatitisa.
English: Undesirable effects in clinical studies and post-marketing in adult patients System organ class
Croatian: Nuspojave uočene u kliničkim ispitivanjima i postmarketinškom praćenju u odraslih bolesnika Klasifikacija organskih sustava
English: Lopinavir/ritonavir does not inhibit CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP2B6 or CYP1A2 at clinically relevant concentrations (see section 4.3).
Croatian: Lopinavir/ritonavir pri klinički značajnim koncentracijama ne inhibira CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP2B6 ni CYP1A2 (vidjeti dio 4.3).
English: Paediatric populations
Croatian: Pedijatrijska populacija
English: − Thirst, frequent urination, blurred vision or weight loss as this may indicate raised sugar levels in the blood.
Croatian: Žeđ, učestalo mokrenje, zamućenje vida ili gubitak težine jer to može upućivati na povišene razine šećera u krvi.
English: Read the list of medicines above ‘Do not take Lopinavir/Ritonavir Mylan with any of the following medicines' for information on medicines that you must not take with lopinavir/ritonavir.
Croatian: Pročitajte popis lijekova gore pod "Nemojte uzimati Lopinavir/Ritonavir Mylan ako istodobno uzimate neke od sljedećih lijekova" za informacije o lijekovima koje ne smijete uzimati dok uzimate lopinavir/ritonavir.
English: Based on known metabolic profiles, clinically significant interactions are not expected between Lopinavir/Ritonavir Mylan and dapsone, trimethoprim/sulfamethoxazole, azithromycin or fluconazole.
Croatian: Na temelju saznanja o metaboličkim profilima, ne očekuju se klinički značajne interakcije između lijeka Lopinavir/Ritonavir Mylan i dapsona, trimetoprima/sulfametoksazola, azitromicina ili flukonazola.
English: It is therefore important that you remain under the supervision of your doctor while taking lopinavir/ritonavir.
Croatian: Stoga je važno da budete pod nadzorom liječnika za vrijeme liječenja lopinavirom/ritonavirom.
English: Rifabutin, 150 mg QD Rifabutin (parent drug and active 25O-desacetyl metabolite):
Croatian: Rifabutin, 150 mg QD Rifabutin (matični lijek i djelatni 25-O-dezacetilni metabolit):
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Croatian: Iako se smatra da je etiologija ove bolesti multifaktorijalna (uključujući upotrebu kortikosteroida, korištenje alkohola, jaku imunosupresiju, viši indeks tjelesne mase) zabilježeni su slučajevi osteonekroze osobito u bolesnika koji imaju uznapredovalu HIV bolest i/ili su primali kombiniranu antiretrovirusnu terapiju (CART) kroz duži vremenski period.
English: The use of a once daily dosing should be limited to those adult patients having only very few protease inhibitor (PI) associated mutations (i.e. less than 3 PI mutations in line with clinical trial results, see section 5.1 for the full description of the population) and should take into account the risk of a lesser sustainability of the virologic suppression (see section 5.1) and higher risk of diarrhoea (see section 4.8) compared to the recommended standard twice daily dosing.
Croatian: Jednodnevni režim doziranja mora biti ograničen na one odrasle bolesnike koji imaju vrlo malo mutijacija povezanih s inhibitorom proteaze (IP) (t.j. manje od 3 mutacije IP u skladu s rezultatima kliničkog ispitivanja, vidjeti dio 5.1 za potpuni opis populacije) te te se mora voditi računa o riziku smanjene održivosti supresije virusa (vidjeti dio 5.1) i višim rizikom za dijareju (vidjeti dio 4.8) u usporedbi s preporučenim standardnim režimom davanja dva puta dnevno.
English: Antimycobacterials Bedaquiline (single dose)
Croatian: Antimikobakterici Bedakilin (pojedinačna doza)
English: Talk to your doctor or pharmacist before taking Lopinavir/Ritonavir Mylan.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete lijek Lopinavir/Ritonavir Mylan.
English: The 4-oxo and 4hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.
Croatian: Epimerni par 4-okso- i 4-hidroksimetabolita glavni su metaboliti s antivirusnim djelovanjem, no njihov je udio u ukupno izmjerenoj radioaktivnosti u plazmi neznatan.
English: Through 360 weeks of treatment, genotypic analysis of viral isolates was successfully conducted in 19 of 28 patients with confirmed HIV RNA above 400 copies/ml revealed no primary or active site mutations in protease (amino acids at positions 8, 30, 32, 46, 47, 48, 50, 82, 84 and 90) or protease inhibitor phenotypic resistance.
Croatian: Kroz 360 tjedana liječenja genotipska analiza virusnih izolata, koja je uspješno provedena u 19 od 28 bolesnika kod kojih je potvrđen HIV RNA iznad 400 kopija/ml, je otkrila nepostojanje primarnih ili aktivnih mjesta mutacija u proteazi (amino kiseline na pozicijama 8, 30, 32, 46, 47, 48, 50, 82, 84 i 90) ili fenotipsku rezistenciju inhibitora proteaze.
English: The effects of lopinavir/ritonavir (in combination with other antiretroviral agents) on biological markers (plasma HIV RNA levels and CD4+ T-cell counts) have been investigated in controlled studies of lopinavir/ritonavir of 48 to 360 weeks duration.
Croatian: Učinci lopinavira/ritonavira (u kombinaciji s ostalim antiretrovirusnim lijekovima) na biološke biljege (razinu HIV RNA u plazmi i broj CD4+ T stanica) ispitivani su u nadziranom ispitivanju lopinavira/ritonavira u trajanju od 48 do 360 tjedana.
English: Since these patients had not previously been exposed to either lopinavir/ritonavir or efavirenz, part of the response may be attributed to the antiviral activity of efavirenz, particularly in patients harbouring highly lopinavir resistant virus.
Croatian: Budući da bolesnici dotad nisu primali ni lopinavir/ritonavir ni efavirenz, odgovor se djelomice može pripisati i protuvirusnoj aktivnosti efavirenza, osobito u bolesnika zaraženih virusom izrazito rezistentnim na lopinavir.
English: When given with Lopinavir/Ritonavir Mylan the recommended dose of rifabutin is 150 mg 3 times per week on set days (for example MondayWednesday-Friday).
Croatian: Kada se daje zajedno s lijekom Lopinavir/Ritonavir Mylan, preporučena doza rifabutina je 150 mg 3 puta tjedno u određene dane (npr. ponedjeljak-srijedapetak).
English: Do not take Lopinavir/Ritonavir Mylan if: - you are allergic to lopinavir, ritonavir or any of the other ingredients of this medicine (listed in section 6); - you have severe liver problems.
Croatian: Nemojte uzimati Lopinavir/Ritonavir Mylan ako: ste alergični na lopinavir, ritonavir ili bilo koji drugi sastojak ovog lijeka (naveden u dijelu 6) imate teške jetrene tegobe.
English: Carbamazepine and Phenobarbital
Croatian: Karbamazepin i Fenobarbital
English: Patients were administered emtricitabine 200 mg once daily and tenofovir DF 300 mg once daily.
Croatian: Bolesnicima su također davani emtricitabin 200 mg jednom dnevno i tenofovir DF 300 mg jednom dnevno.
English: Sixty-one patients completed the study (35 patients received the recommended 400/100 mg twice daily dose throughout the study).
Croatian: 61 bolesnik završio je studiju (35 bolesnika primalo je preporučenu dozu od 400/100 mg dva puta dnevno tijekom cijelog ispitivanja).
English: Nevirapine, 200 mg BID Lopinavir: AUC: ↓ 27%
Croatian: Nevirapin, 200 mg BID Lopinavir: AUC: ↓ 27%
English: When used for osteo-articular infections, where the coadministration is unavoidable, close clinical monitoring for muscular adverse events is strongly recommended (see section 4.4).
Croatian: Kada se koristi za osteoartikularne infekcije pri čemu je istodobna primjena neizbježna, snažno je preporučeno pomno kliničko praćenje štetnih događaja povezanih s mišićnim sustavom (vidjeti dio 4.4).
English: When you travel or need to stay in the hospital make sure you will have enough lopinavir/ritonavir to last until you can get a new supply.
Croatian: Ukoliko putujete ili ostajete neko vrijeme u bolnici, uzmite dovoljnu količinu lopinavira/ritonavira koja će potrajati dok ne dobijete novu količinu lopinavira/ritonavira.
English: Inhibition of HIV protease prevents cleavage of the gag-pol polyprotein resulting in the production of immature, non-infectious virus.
Croatian: Inhibicijom proteaze HIV-a sprječava se cijepanje poliproteina gag-pol, zbog čega se stvara nezreli, neinfektivni virus.
English: (see section 4.5); - riociguat is not recommended (see section 4.5); - vorapaxar is not recommended (see section 4.5); - fusidic acid in osteo-articular infections is not recommended (see section 4.5); - salmeterol is not recommended (see section 4.5); - rivaroxaban is not recommended (see section 4.5).
Croatian: Kombinacija lopinavira/ritonavira s: - tadalafilom, indiciranim za liječenje plućne arterijske hipertenzije, se ne preporučuje (vidjeti dio 4.5); - riocigvatom se ne preporučuje (vidjeti dio 4.5); - vorapaksarom se ne preporučuje (vidjeti dio 4.5); - fusidatnom kiselinom kod osteoartikularne infekcije nije preporučljiva (vidjeti dio 4.5); - salmeterolom se ne preporučuje (vidjeti dio 4.5); - rivaroksabanom se ne preporučuje (vidjeti dio 4.5).
English: The 19 isolates demonstrated a 4.3-fold increase in IC50 compared to baseline isolates (from 6.2- to 43-fold, compared to wild-type virus).
Croatian: Ukupno 19 izolata pokazalo je porast od 4,3 puta u IC50 u usporedbi s početnim izolatima (povećanje od 6,2 puta do 43 puta, u usporedbi s divljim tipom virusa).
English: The efficacy data favouring the twice-daily regimen are reinforced by a differential in pharmacokinetic parameters significantly favouring the twice-daily regimen (see section 5.2).
Croatian: Podaci o učinkovitosti govore u prilog doziranju dvaput na dan kao i razlike u farmakokinetičkim parametrima koji značajno govore u prilog doziranju dvaput na dan (vidjeti dio 5.2).
English: Strong CYP3A4 inhibitors such as protease inhibitors may increase bedaquiline exposure which could potentially increase the risk of bedaquiline related adverse reactions.
Croatian: Snažni inhibitori CYP3A4 poput inhibitora proteaza mogu povisiti izloženost bedakilinu što može potencijalno dovesti do povećanog rizika od nuspojava uzrokovanih bedakilinom.
English: If a patient is already taking St John's wort, stop St John's wort and if possible check viral levels.
Croatian: Ako bolesnik već uzima gospinu travu, treba ju prestati uzimati i ako je moguće provjeriti razinu virusa.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and can occur many months after initiation of treatment (see section 4.4).
Croatian: Zabilježena je pojava autoimunih poremećaja (kao što je Gravesova bolest i autoimuni hepatitis), međtim, zabilježeno vrijeme do pojave je vrlo varijabilno i može se pojaviti i mnogo mjeseci nakon početka liječenja (vidjeti dio 4.4).
English: Blood glucose disorders including diabetes mellitus, hypertriglyceridaemia, hypercholesterolemia, weight decreased, decreased appetite
Croatian: Poremećaj glukoze u krvi, uključujući diabetes mellitus, hipertrigiliceridemiju, hiperkolesterolemiju, smanjenje tjelesne težine, smanjenje apetita
English: Phosphodiesterase (PDE5) inhibitors Avanafil (ritonavir 600 mg BID)
Croatian: Inhibitori fosfodiesteraze 5 (PDE5) Avanafil (ritonavir 600 mg BID)
English: Lopinavir/ritonavir has been shown in vivo to induce its own metabolism and to increase the biotransformation of some medicinal products metabolised by cytochrome P450 enzymes (including CYP2C9 and CYP2C19) and by glucuronidation.
Croatian: Utvrđeno je da lopinavir/ritonavir in vivo inducira vlastiti metabolizam i povećava biotransformaciju nekih lijekova koji se metaboliziraju putem enzima citokroma P450 (uključujući CYP2C9 i CYP2C19) i putem glukuronidacije.
English: In general, rebound isolates either retained (if cross-resistant at baseline) or developed significant cross-resistance to indinavir, saquinavir and atazanavir.
Croatian: Izolirani sojevi kod porasta broja virusa su, uglavnom, sadržavali (ako su bili križno rezistentni na početku) ili razvili značajnu križnu rezistenciju na indinavir, sakvinavir i atazanavir.
English: If the benefit is considered to outweigh the risk and Lopinavir/Ritonavir Mylan must be used, reduce the ibrutinib dose to 140 mg and monitor patient closely for toxicity.
Croatian: Ukoliko se smatra da korist nadmašuje rizik i lijek Lopinavir/Ritonavir Mylan se mora koristiti, dozu ibrutiniba treba smanjiti na 140 mg i pomno pratiti bolesnika radi toksičnosti.
English: If you are taking lopinavir/ritonavir once a day
Croatian: Ako uzimate lopinavir/ritonavir jedanput na dan
English: Increased creatine phosphokinase (CPK), myalgia, myositis, and rarely, rhabdomyolysis have been reported with protease inhibitors, particularly in combination with nucleoside reverse transcriptase inhibitors.
Croatian: Povišenje kreatin fosfokinaze (CPK), mijalgija, miozitis i rijetko rabdomioliza zabilježeni su tijekom primjene inhibitora proteaze, pogotovo u kombinaciji s nukleozidnim inhibitorima reverzne transkriptaze.
English: The signs of toxicity observed in mice, rats or dogs included decreased activity, ataxia, emaciation, dehydration and tremors.
Croatian: Znakovi otrovanja kod miševa, štakora ili pasa obuhvaćaju smanjenu aktivnost, ataksiju, ekstremno mršavljenje, dehidraciju i tremor.
English: In case of co-administration of Lopinavir/Ritonavir Mylan with contraceptives containing ethinyl oestradiol (whatever the contraceptive formulation e.g. oral or patch), additional methods of contraception must be used.
Croatian: U slučaju istodobne primjene lijeka Lopinavir/Ritonavir Mylan s kontraceptivima koji sadrže etinilestradiol (bez obzira na formulaciju kontraceptiva npr. je li primjena peroralna ili u flasteru), moraju se koristiti dodatne metode kontracepcije.
English: Caution is warranted and therapeutic drug concentration monitoring is recommended when available.
Croatian: Nužan je oprez, a preporučuje se i terapijsko praćenje lijekova, ukoliko je ono moguće.
English: Recommended number of 100/25 mg tablets twice-daily
Croatian: Preporučen broj tableta 100/25 mg dva puta dnevno
English: If the use of atorvastatin is considered strictly necessary, the lowest possible dose of atorvastatin should be administered with careful safety monitoring.
Croatian: Ako se utvrdi da je primjena atorvastatina nužna, mora se primjeniti najniža moguća doza uz pažljivo nadziranje primjene.
English: The choice of lopinavir/ritonavir to treat protease inhibitor experienced HIV-1 infected patients should be based on individual viral resistance testing and treatment history of patients (see sections 4.4 and 5.1).
Croatian: Izbor lopinavira/ritonavira za liječenje osoba s HIV-1 infekcijom, koji su prethodno primali inhibitor proteaze, mora se zasnivati na provjeri individualne virusne rezistencije i povijesti liječenja bolesnika (vidjeti dijelove 4.4 and 5.1).
English: Hypersensitivity including urticaria and angioedema
Croatian: Preosjetljivost uključujući urtikariju i angioedem
English: No subject experienced an increase in QTcF of ≥ 60 ms from baseline or a QTcF interval exceeding the potentially clinically relevant threshold of 500 ms.
Croatian: Niti jedna osoba koja je sudjelovala u studiji nije imala povećanje QTcF ≥ 60 msec u odnosu na početnu vrijednost ili QTcF interval koji je prešao klinički značajan prag od 500 msec.
English: − The usual adult dose is 400 mg/100 mg twice a day i.e. every 12 hours, in combination with other antiHIV medicines.
Croatian: Uobičajena doza za odrasle je 400 mg/100 mg dva puta dnevno, tj. svakih 12 sati u kombinaciji s drugim anti- HIV lijekovima.
English: − Breast-feeding mothers should not take lopinavir/ritonavir unless specifically directed by the doctor.
Croatian: Dojilje ne smiju uzimati lopinavir/ritonavir, osim ako im to izričito ne kaže liječnik.
English: HDPE bottle: After first opening, use within 120 days.
Croatian: Boca od polietilena visoke gustoće (HDPE): nakon prvog otvaranja iskoristiti u roku od 120 dana.
English: The in vitro antiviral EC50 of lopinavir is approximately 10-fold lower than that of ritonavir.
Croatian: Antivirusna EC50 lopinavira oko 10 puta je manja od one ritonavira in vitro.
English: After 48 weeks of treatment with lopinavir/ritonavir, efavirenz and nucleoside reverse transcriptase inhibitors, plasma HIV RNA ≤ 400 copies/ml was observed in 93% (25/27), 73% (11/15), and 25% (2/8) of patients with < 10-fold, 10 to 40-fold, and > 40-fold reduced susceptibility to lopinavir at baseline, respectively.
Croatian: Nakon 48 tjedana terapije lopinavirom/ritonavirom, efavirenzom i nukleozidnim inhibitorima reverzne transkriptaze, ≤ 400 kopija HIV RNA/ml plazme nađeno je, redom, u 93% (25/27), 73% (11/15), i 25% (2/8) bolesnika s < 10 puta manjom, 10-40 puta manjom, i > 40 puta manjom početnom osjetljivošću na lopinavir.
English: − You must not take lopinavir/ritonavir with sildenafil used to treat pulmonary arterial hypertension (high blood pressure in the pulmonary artery) (see also Do not take Lopinavir/Ritonavir Mylan section above).
Croatian: Ne smijete uzimati lopinavir/ritonavir sa sildenafilom koji se koristi za liječenje plućne arterijske hipertenzije (visok krvni tlak u plućnoj arteriji) (pogledajte dio Nemojte uzimati Lopinavir/Ritonavir Mylan gore u tekstu).
English: Children were eligible when they were aged <18 years, ≥15 kg in weight, receiving cART that included lopinavir/ritonavir, HIV-1 ribonucleic acid (RNA) <50 copies/ml for at least 24 weeks and able to swallow tablets.
Croatian: Djeca su morala biti < 18 godina, ≥ 15 kg tjelesne težine, primati cART koje uključuje lopinavir/ritonavir, imati HIV-1 ribonukleinsku kiselinu (RNK) < 50 kopija/ml najmanje 24 tjedna te su morala moći progutati tablete.
English: EXP After first opening, use within 120 days.
Croatian: Nakon prvog otvaranja iskoristiti u roku od 120 dana.
English: Particular caution must be used when prescribing lopinavir/ritonavir and medicinal products known to induce QT interval prolongation such as: chlorpheniramine, quinidine, erythromycin, clarithromycin.
Croatian: Nužan je osobit oprez kada se propisuju lopinavir/ritonavir i lijekovi za koje se zna da produžuju QTinterval kao što su: klorfeniramin, kinidin, eritromicin, klaritromicin.
English: In post-marketing surveillance through the Antiretroviral Pregnancy Registry, established since January 1989, an increased risk of birth defects exposures with lopinavir/ritonavir has not been reported among over 1000 women exposed during the first trimester.
Croatian: U praćenju nakon stavljanja lijeka u promet kroz Registar trudnoća izloženih antiretroviralnim lijekovima “Antiretroviral Pregnancy Registry” utemeljen u siječnju 1989. nije zabilježen povećan rizik od kongenitalnih oštećenja kod više od 1000 žena koje su bile izložene lopinaviru/ritonaviru tijekom prvog tromjesečja.
English: Sustained virological response to lopinavir/ritonavir (in combination with nucleoside/nucleotide reverse transcriptase inhibitors) has been also observed in a small Phase II study (M97-720) through 360 weeks of treatment.
Croatian: Održani virološki odgovor na lopinavir/ritonavir (u kombinaciji s nukleozidnim/nukleotidnim inhibitorima reverzne transkriptaze) zabilježen je i u malom ispitivanju II. faze (M97-720), u kojem su bolesnici primali terapiju 360 tjedana.
English: While rosuvastatin is poorly metabolised by CYP3A4, an increase of its plasma concentrations was observed.
Croatian: Iako se rosuvastatin slabo metabolizira putem CYP3A4, uočene je povećanje njegovih koncentracija u plazmi.
English: Patients with pre-existing liver dysfunction including chronic hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Croatian: U bolesnika s već postojećom disfunkcijom jetre, uključivši kronični hepatitis, učestaliji su poremećaji funkcije jetre za vrijeme kombinirane terapije antiretrovirusnim lijekovima, te bolesnike se mora pratiti u skladu sa standardnom medicinskom praksom.
English: Lopinavir/ritonavir is likely to increase plasma concentrations of medicinal products that are primarily metabolised by CYP3A.
Croatian: Lopinavir/Ritonavir će vjerojatno povisiti plazmatske koncentracije lijekova koji se prvenstveno metaboliziraju putem CYP3A.
English: Concomitant use of Lopinavir/Ritonavir Mylan with rilpivirine causes an increase in the plasma concentrations of rilpivirine, but no dose adjustment is required.
Croatian: Istodobna primjena lijeka Lopinavir/Ritonavir Mylan s rilpivirinom uzrokuje povišenje koncentacije rilpivirina u plazmi, ali nije potrebno prilagođavanje doze.
English: Lopinavir/ritonavir pharmacokinetics have not been studied in older people.
Croatian: Farmakokinetika lopinavira/ritonavira u starijih ljudi nije ispitana.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jiroveci pneumonia.
Croatian: Mjerodavni su primjeri retinitis izazvan citomegalovirusom, generalizirane i/ili fokalne infekcije mikobakterijama i upala pluća prouzročena s Pneumocystis jiroveci.
English: If you are taking lopinavir/ritonavir twice a day
Croatian: Ako uzimate lopinavir/ritonavir dvaput na dan
English: − Nausea, vomiting, abdominal pain, difficulty breathing and severe weakness of the muscles in the legs and arms as these symptoms may indicate raised lactic acid levels.
Croatian: Mučninu, povraćanje, bol u trbuhu, otežano disanje i tešku slabost mišića u nogama i rukama jer ti simptomi mogu upućivati na povećanu koncentraciju mliječne kiseline.
English: - 1 bottle of 60 film-coated tablets.
Croatian: - 1 boca sa 60 filmom obloženih tableta.
English: Read all of this leaflet carefully before you start taking this medicine because it contains important information for you or your child. - Keep this leaflet.
Croatian: Vi ili Vaše dijete počnete uzimati ovaj lijek jer sadrži Vama važne podatke.
English: In patients currently taking Lopinavir/Ritonavir Mylan and starting lamotrigine: no dose adjustments to the recommended dose escalation of lamotrigine should be necessary.
Croatian: Bolesnici koji trenutno uzimaju Lopinavir/Ritonavir Mylan i započinju uzimanje lamotrigina: Nije potrebna prilagodba u vidu preporučenog povećanja doze lamotrigina.
English: Co-administration of delamanid with a strong inhibitor of CYP3A (as lopinavir/ritonavir) may increase exposure to delamanid metabolite, which has been associated with QTc prolongation.
Croatian: Istodobna primjena delamanida sa snažnim inhibitorom CYP3A (poput lopinavira/ritonavira) može blago povisiti izloženost metabolitu delamanida, koji je povezan s produljenjem QTc intervala.
English: Pack sizes available are:
Croatian: Dostupne veličine pakiranja:
English: − Taking lopinavir/ritonavir as recommended should give you the best chance of delaying the development of resistance to the product.
Croatian: Uzimanje lopinavira/ritonavira sukladno preporukama daje najveće šanse za odgađanjem razvoja otpornosti na lijek.