FrancophonIA/ELRC3.0 huggingface dataset:
English: The external control group included 86 patients treated with available therapy (as above) mostly at the same time and at the same sites as the patients treated with posaconazole.
Croatian: U vanjsku kontrolnu skupinu bilo je uključeno 86 bolesnika liječenih dostupnom terapijom (kao gore) većinom u isto vrijeme i na istim mjestima kao i bolesnici liječeni posakonazolom.
English: HIV Protease inhibitors
Croatian: Inhibitori HIV proteaze
English: 319 Pinner Road North Harrow Middlesex
Croatian: 319 Pinner Road North Harrow
English: Talk to your doctor or pharmacist before taking Posaconazole Accord - if you have had an allergic reaction to another antifungal medicine such as ketoconazole,
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete Posakonazol Accord: - ako ste ikada imali alergijsku reakciju na druge antimikotike kao što su ketokonazol, flukonazol,
English: Sulfonylureas
Croatian: Sulfonilureje
English: Rarely, more severe hepatic reactions with fatal outcomes have been reported.
Croatian: Rijetko su prijavljene teške jetrene reakcije sa smrtnim ishodom.
English: - efavirenz and fosamprenavir used to treat HIV infection.
Croatian: - efavirenz i fosamprenavir, koji se koriste za liječenje HIV-infekcije.
English: Do not take Posaconazole Accord if you are pregnant unless you are told to by your doctor.
Croatian: Nemojte uzeti Posakonazol Accord ako ste trudni, osim ako Vam to nije preporučio Vaš liječnik.
English: Combination with other antifungal agents
Croatian: Kombinacija s drugim antimikoticima
English: A higher incidence of adverse reactions cannot be ruled out.
Croatian: Ne može se isključiti veća incidencija nuspojava.
English: No pharmacokinetic data are available from paediatric patients less than 8 years of age.
Croatian: Nema farmakokinetičkih podataka za pedijatrijske bolesnike mlađe od 8 godina.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/19/1379/001-004
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/19/1379/001-004
English: This finding was not seen in monkeys dosed for one year.
Croatian: Ovaj nalaz nije ustanovljen u majmuna koji su primali lijek tijekom godine dana.
English: Triplex (PVC/PE/PVdC) white opaque-aluminium blister or perforated unit dose blister in cartons of 24 or 96 tablets.
Croatian: Trostruki (PVC/PE/PVdc) bijeli neprozirni aluminijski blister ili perforirani blister s jediničnim dozama u kutijama s 24 ili 96 tableta.
English: Duration of therapy is based on recovery from neutropenia or immunosuppression.
Croatian: Trajanje terapije temelji se na oporavku od neutropenije ili imunosupresije.
English: A correlation between total medicinal product exposure divided by MIC (AUC/MIC) and clinical outcome was observed.
Croatian: Opažena je korelacija između ukupne izloženosti lijeku podijeljene s najmanjom inhibitornom koncentracijom(AUC/MIK) i kliničkog ishoda.
English: TreatmentInvasive Aspergillosis Study 0041
Croatian: Liječenje invazivna aspergiloza Ispitivanje 0041
English: In Study 316, overall mortality was similar (POS, 25%; FLU, 28%); however, the proportion of IFI- related deaths was significantly lower in the POS group (4/301) compared with the FLU group (12/299; P= 0.0413).
Croatian: U ispitivanju 316 utvrđen je sličan ukupni mortalitet (POS, 25%; FLU, 28%); međutim, udio smrti povezanih s IGI bio je značajno niži u skupini koja je uzimala POS (4/301) nego u skupini koja je primala FLU (12/299; p = 0,0413).
English: Look at the list of medicines given above that must not be taken while you are taking Posaconazole Accord.
Croatian: Pročitajte gore navedeni popis lijekova koji se ne smiju uzimati dok uzimate Posakonazol Accord.
English: Most of the cases of aspergillosis were considered to be refractory to prior therapy in both the posaconazole group (88%) and in the external control group (79%).
Croatian: Većina slučajeva aspergiloze smatrala se otpornom na prethodnu terapiju kako u skupini koja je primala posakonazol (88 %), tako i u vanjskoj kontrolnoj skupini (79 %).
English: 200 mg three times daily
Croatian: 200 mg triput na dan
English: Refractoriness is defined as progression of infection or failure to improve after a minimum of 7 days of prior therapeutic doses of effective antifungal therapy.
Croatian: Izostanak odgovora na liječenje definira se kao napredovanje infekcije ili izostanak poboljšanja nakon najmanje 7 dana primjene terapijskih doza učinkovitih antimikotika.
English: Based on Kaplan-Meier estimates, the probability of survival up to day 100 after randomization, was significantly higher for posaconazole recipients; this survival benefit was demonstrated when the analysis considered all causes of death (P=0.0354) as well as IFI-related deaths (P = 0.0209).
Croatian: Na temelju Kaplan-Meierovih procjena, vjerojatnost preživljenja do 100. dana nakon randomizacije bila je značajno veća u bolesnika koji su primali posakonazol; taj se koristan utjecaj na preživljenje pokazao kada je analiza obuhvatila sve uzroke smrti (p = 0,0354) kao i smrti povezane s IGI (p = 0,0209).
English: Patient management should include laboratory evaluation of hepatic function (particularly liver function tests and bilirubin).
Croatian: Zbrinjavanje tih bolesnika mora uključivati laboratorijsku procjenu funkcije jetre (osobito pretrage funkcije jetre i bilirubina).
English: One subject (<1%) had a predicted Cav below 500 ng/mL and 19% of the subjects had a predicted Cav above 2,500 ng/mL.
Croatian: Jedan ispitanik (<1%) imao je predviđeni Cav manji od 500 ng/ml, a 19% ispitanika imalo je predviđeni Cav veći od 2500 ng/ml.
English: The elimination half-life (t1/2) was prolonged from approximately 27 hours up to ~43 hours in respective groups.
Croatian: Poluvrijeme eliminacije (t1/2) je u odgovarajućim skupinama produljeno sa približno 27 sati na ~43 sata.
English: Pharmacokinetic / Pharmacodynamic relationships
Croatian: Farmakokinetički/farmakodinamički odnosi
English: No overall differences in safety were observed between the geriatric patients and younger patients; therefore, no dosage adjustment is recommended for geriatric patients.
Croatian: Nisu opažene općenite razlike u sigurnosti između starijih i mlađih bolesnika pa se stoga ne preporučuje prilagodba doze u starijih bolesnika.
English: Elevated liver function tests were generally reversible on discontinuation of therapy and in some instances these tests normalised without interruption of therapy.
Croatian: Povišeni rezultati pretraga funkcije jetre bili su u pravilu reverzibilni po prekidu terapije, a u nekim su se slučajevima normalizirali i bez prekida terapije.
English: The use of combination antifungal therapies should not decrease the efficacy of either posaconazole or the other therapies; however, there is currently no clinical evidence that combination therapy will provide an added benefit.
Croatian: Primjena kombiniranog liječenja antimikoticima ne bi trebala umanjiti djelotvornost ni posakonazola niti drugih lijekova; međutim, trenutno nema kliničkih dokaza da kombinirana terapija donosi dodatnu korist.
English: Other medicines
Croatian: Drugi lijekovi
English: Some azoles have been associated with prolongation of the QTc interval.
Croatian: Primjena nekih azola povezuje se s produljenjem QTc-intervala.
English: In Study 1899, a significant decrease in all cause mortality in favour of posaconazole was observed [POS 49/304 (16%) vs. FLU/ITZ 67/298 (22%) p= 0.048].
Croatian: U Ispitivanju 1899 opaženo je značajno smanjenje smrtnosti zbog bilo kojeg uzroka u korist posakonazola [POS 49/304 (16 %) naspram FLU/ITZ 67/298 (22 %) p = 0,048].
English: Midazolam and other benzodiazepines
Croatian: Midazolam i drugi benzodiazepini
English: The subject population included: 1) patients with AML or MDS who had recently received chemotherapy and had developed or were anticipated to develop significant neutropenia, or 2) patients who had undergone a HSCT and were receiving immunosuppressive therapy for prevention or treatment of GVHD.
Croatian: U populaciju ispitanika bili su uključeni: 1) bolesnici s AML-om ili MDS-om koji su nedavno primili kemoterapiju i razvili su ili se očekivalo da će razviti značajnu neutropeniju; ili 2) bolesnici koji su podvrgnuti HSCT-u i koji su primali imunosupresivnu terapiju za prevenciju ili liječenje GVHD-a.
English: Posaconazole inhibits the enzyme lanosterol 14α-demethylase (CYP51), which catalyses an essential step in ergosterol biosynthesis.
Croatian: Posakonazol inhibira enzim lanosterol 14α-demetilazu (CYP51) koji katalizira jedan neophodan korak u biosintezi ergosterola.
English: The following medicines may decrease the effectiveness of Posaconazole Accord by decreasing the amount of Posaconazole Accord in the blood: - rifabutin and rifampicin (used to treat certain infections).
Croatian: Sljedeći lijekovi mogu smanjiti učinkovitost lijeka Posakonazol Accord tako što smanjuju njegovu količinu u krvi: - rifabutin i rifampicin (primjenjuju se za liječenje nekih infekcija).
English: OTHER SPECIAL WARNING(S), IF NECESSARY Posaconazole oral suspension and tablets are NOT interchangeable.
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A), AKO JE POTREBNO Oralna otopina i tablete posakonazola NISU međusobno zamjenjivi.
English: Glucose concentrations decreased in some healthy volunteers when glipizide was co-administered with posaconazole.
Croatian: Koncentracija glukoze se u nekih zdravih dobrovoljaca smanjila kad se glipizid primjenjivao istodobno s posakonazolom.
English: Based on pharmacokinetic data in 10 of these paediatric patients, the pharmacokinetic profile appears to be similar to patients ≥ 18 years of age.
Croatian: Na temelju farmakokinetičkih podataka u 10 od tih pedijatrijskih bolesnika, čini se da je farmakokinetički profil lijeka sličan onomu u bolesnika u dobi od ≥18 godina.
English: EUCAST ECOFF values: - Aspergillus flavus: 0.5 mg/L - Aspergillus fumigatus: 0.25 mg/L - Aspergillus nidulans: 0.5 mg/L - Aspergillus niger: 0.5 mg/L - Aspergillus terreus: 0.25 mg/L
Croatian: EUCAST ECOFF vrijednosti: - Aspergillus flavus: 0,5 mg/l - Aspergillus fumigatus: 0,25 mg/l - Aspergillus nidulans: 0,5 mg/l - Aspergillus niger: 0,5 mg/l - Aspergillus terreus: 0,25 mg/l
English: diplopia, scotoma
Croatian: diplopija, skotomi
English: pulmonary hypertension, interstitial pneumonia, pneumonitis
Croatian: plućna hipertenzija, intersticijska upala pluća, pneumonitis
English: abnormal dreams, confusional state, sleep disorder
Croatian: neuobičajeni snovi, stanje konfuzije, poremećaj spavanja
English: 24x1 gastro-resistant tablet 96x1 gastro-resistant tablet
Croatian: 24x1 želučanootporna tableta 96x1 želučanootporna tableta
English: Posaconazole must not be used during pregnancy unless the benefit to the mother clearly outweighs the potential risk to the foetus.
Croatian: Posakonazol se ne smije uzimati tijekom trudnoće, osim ako korist liječenja za majku jasno nadilazi mogući rizik za plod.
English: Moreover, sparse PK samples were collected at several days during steady state before the next dose (Cmin) for a larger subject population.
Croatian: Nadalje, rijetki uzorci za procjenu farmakokinetike bili su prikupljani nekoliko dana u stanju dinamičke ravnoteže prije sljedeće doze (Cmin) kod veće populacije ispitanika.
English: Co-administration of posaconazole with sirolimus is not recommended and should be avoided whenever possible.
Croatian: Istodobna primjena posakonazola i sirolimusa se ne preporučuje i treba je izbjegavati kad god je to moguće.
English: Study 5615 was a non-comparative multi-center study performed to evaluate the pharmacokinetic properties, safety, and tolerability of posaconazole tablet.
Croatian: Ispitivanje 5615 bilo je nekomparativno, multicentrično ispitivanje provedeno kako bi se procjenila farmakokinetička svojstva, sigurnost i podnošljivost tableta posakonazola.
English: The excreted metabolites in urine and faeces account for approximately 17% of the administered radiolabelled dose.
Croatian: Izlučeni metaboliti u mokraći i stolici čine oko 17% primijenjene radioaktivno označene doze.
English: For patients with acute myelogenous leukemia or myelodysplastic syndromes, prophylaxis with Posaconazole Accord should start several days before the anticipated onset of neutropenia and continue for 7 days after the neutrophil count rises above 500 cells per mm3.
Croatian: U bolesnika s akutnom mijeloičnom leukemijom ili mijelodisplastičnim sindromima profilaksu lijekom Posakonazol Accord treba započeti nekoliko dana prije očekivanog nastupa neutropenije i nastaviti još 7 dana nakon što broj neutrofila poraste na više od 500 stanica po mm3.
English: New diagnosis of acute myelogenous leukaemia was the most common underlying condition (435/602, [72%]).
Croatian: Najčešća osnovna bolest bila je novodijagnosticirana akutna mijeloična leukemija (435/602, [72 %]).
English: Plasma exposure
Croatian: Izloženost u plazmi
English: Within the organ system classes, adverse reactions are listed under headings of frequency using the following categories: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥ 1/10,000 to <1/1,000); very rare (<1/10,000); not known.
Croatian: Unutar klasifikacije organskih sustava, nuspojave su navedene prema učestalosti pojavljivanja definiranoj kao: vrlo često (≥1/10); često (≥1/100 i <1/10); manje često (≥1/1000 i <1/100); rijetko
English: The safety profile of tablets was similar to that of the oral suspension.
Croatian: Sigurnosni profil primjene tableta bio je sličan profilu oralne suspenzije.
English: The safety and efficacy of posaconazole in children aged below 18 years have not been established.
Croatian: Sigurnost i djelotvornost posakonazola u djece mlađe od 18 godina nisu ustanovljene.
English: The majority (377/600, [63%]) of patients included had Acute Grade 2 or 3 or chronic extensive (195/600, [32.5%])
Croatian: Većina uključenih bolesnika (377/600, [63 %]) je na početku ispitivanja imala akutni GVHD stupnja 2 ili 3 ili kronični opsežni GVHD (195/600, [32,5 %]).
English: Cav Range (ng/mL)
Croatian: Cav raspon (ng/ml)
English: gastrointestinal haemorrhage, ileus
Croatian: gastrointestinalno krvarenje, ileus
English: Duration of therapy should be based on the severity of the underlying disease, recovery from immunosuppression, and clinical response.
Croatian: Trajanje terapije treba se temeljiti na težini osnovne bolesti, oporavku nakon imunosupresije i kliničkom odgovoru.
English: The microbiological data suggest that posaconazole is active against Rhizomucor, Mucor, and Rhizopus; however the clinical data are currently too limited to assess the efficacy of posaconazole against these causative agents.
Croatian: Mikrobiološki podaci ukazuju da posakonazol djeluje na Rhizomucor, Mucor i Rhizopus, no trenutno nema dovoljno kliničkih podataka za procjenu djelotvornosti posakonazola na te uzročnike.
English: How to store Posaconazole Accord Contents of the pack and other information
Croatian: Kako čuvati Posakonazol Accord Sadržaj pakiranja i druge informacije
English: Prophylaxis of Invasive Fungal Infections (IFIs) (Studies 316 and 1899) Two randomised, controlled prophylaxis studies were conducted among patients at high risk for developing invasive fungal infections.
Croatian: Profilaksa invazivnih gljivičnih infekcija (IGI) (Ispitivanja 316 i 1899) Dva randomizirana kontrolirana ispitivanja profilaktičke primjene provedena su u bolesnika s visokim rizikom za razvoj invazivnih gljivičnih infekcija.
English: d: All randomized e: All treated
Croatian: Svi randomizirani e:
English: There are currently insufficient data to set clinical breakpoints for other Candida species.
Croatian: Trenutno nema dovoljno podataka prema kojima bi se odredile kliničke granične vrijednosti za druge vrste roda Candida.
English: Posaconazole is also available as 40 mg/mL oral suspension and 300 mg concentrate for solution for infusion.
Croatian: Posakonazol je također dostupan u obliku 40 mg/ml oralne suspenzije i koncentrata za otopinu za infuziju od 300 mg.
English: Yellow coated, capsule shaped tablet of approximate 17.5 mm length and 6.7 mm width, debossed with “100P” on one side and plain on the other side.
Croatian: Žuta obložena tableta u obliku kapsule, duljine približno 17,5 mm i širine približno 6,7 mm, s utisnutim „100P“ na jednoj strani i bez oznake na drugoj strani.
English: In addition to the medicines named above there are other medicines that carry a risk of rhythm problems that may be greater when they are taken with Posaconazole Accord.
Croatian: Pored gore navedenih lijekova, postoje i drugi lijekovi koji nose rizik od nastanka poteškoća sa srčanim ritmom, koji se može povećati ako se uzimaju s lijekom Posakonazol Accord.
English: Do not take Posaconazole Accord if any of the above apply to you.
Croatian: Nemojte uzimati Posakonazol Accord ako se nešto od gore navedenog odnosi na Vas.
English: liver function tests raised (ALT increased, AST increased, bilirubin increased, alkaline phosphatase increased, GGT increased)
Croatian: povišene vrijednosti testova funkcije jetre (povišen ALT, povišen AST, povišen bilirubin, povišena alkalna fosfataza, povišen GGT)
English: There is no clinical experience assessing the impact of posaconazole on fertility in humans.
Croatian: Nema kliničkog iskustva kojim bi se mogao procijeniti utjecaj posakonazola na plodnost u ljudi.
English: What you need to know before you take Posaconazole Accord
Croatian: Što morate znati prije nego počnete uzimati Posakonazol Accord
English: menstrual disorder
Croatian: poremećaj menstrualnog ciklusa
English: If you take more Posaconazole Accord than you should If you think that you may have taken too much Posaconazole Accord, talk to a doctor or go to the hospital straight away.
Croatian: Ako uzmete više lijeka Posakonazol Accord nego što ste trebali Ako mislite da ste uzeli previše lijeka Posakonazol Accord, odmah se obratite liječniku ili otiđite u bolnicu.
English: Posaconazole is a potent inhibitor of CYP3A4.
Croatian: Posakonazol je snažan inhibitor CYP3A4.
English: Similar recommendations apply to posaconazole tablets; however, a specific study has not been conducted with the posaconazole tablets.
Croatian: Slične preporuke vrijede i za tablete posakonazola; međutim, nije provedeno posebno ispitivanje s tabletama posakonazola.
English: Study 5615 was conducted in a similar patient population to that previously studied in the pivotal posaconazole oral suspension clinical program.
Croatian: Ispitivanje 5615 provedeno je u populaciji bolesnika koja je bila slična onoj prethodno ispitanoj u glavnom kliničkom programu ispitivanja oralne suspenzije posakonazola.
English: Quartile pCav Range (ng/mL)
Croatian: Kvartil pCav raspon (ng/ml)
English: As HIV protease inhibitors are CYP3A4 substrates, it is expected that posaconazole will increase plasma levels of these antiretroviral agents.
Croatian: Budući da su inhibitori HIV proteaze supstrati CYP3A4, očekuje se da će posakonazol povisiti koncentraciju ovih antiretrovirusnih lijekova u plazmi.
English: Most of the vinca alkaloids (e.g., vincristine and vinblastine) are substrates of CYP3A4.
Croatian: Većina vinka alkaloida (npr. vinkristin i vinblastin) supstrati su CYP3A4.
English: Posaconazole, after administration of the tablet, has a mean apparent volume of distribution of 394 L (42%), ranging between 294-583 L among the studies in healthy volunteers.
Croatian: Nakon primjene tablete, posakonazol ima srednju vrijednost prividnog volumena distribucije od 394 l (42 %), koji se kreće u rasponu od 294-583 l u ispitivanjima u zdravih dobrovoljaca.
English: Posaconazole tablets are absorbed with a median Tmax of 4 to 5 hours and exhibits dose proportional pharmacokinetics after single and multiple dosing up to 300 mg.
Croatian: Tablete posakonazola apsorbiraju se uz medijan tmax od 4 do 5 sati i pokazuju farmakokinetiku proporcionalnu dozi nakon jednokratnog i višekratnog doziranja do 300 mg.
English: In twelve-month neurotoxicity studies in dogs and monkeys, no functional effects were observed on the central or peripheral nervous systems at systemic exposures greater than those achieved therapeutically.
Croatian: U dvanaestomjesečnim ispitivanjima neurotoksičnosti na psima i majmunima nisu opaženi funkcionalni učinci na središnji ili periferni živčani sustav pri sistemskoj izloženosti većoj od one koja se postiže tijekom liječenja.
English: The addition of posaconazole to therapy with atazanavir or with atazanavir plus ritonavir was associated with increases in plasma bilirubin levels.
Croatian: Dodavanje posakonazola terapiji s atazanavirom ili atazanavirom i ritonavirom bilo je povezano s povišenim razinama bilirubina u plazmi.
English: blurred vision, photophobia, visual acuity reduced
Croatian: zamagljen vid, fotofobija, smanjena oštrina vida
English: Posaconazole has been shown in vitro to be active against the following microorganisms: Aspergillus species (Aspergillus fumigatus, A. flavus, A. terreus, A. nidulans, A. niger, A. ustus), Candida species (Candida albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. dubliniensis, C. famata, C. inconspicua, C. lipolytica, C. norvegensis, C. pseudotropicalis), Coccidioides immitis, Fonsecaea pedrosoi, and species of Fusarium, Rhizomucor, Mucor, and Rhizopus.
Croatian: Pokazalo se da posakonazol in vitro djeluje na sljedeće mikroorganizme: vrste roda Aspergillus (Aspergillus fumigatus, A. flavus, A. terreus, A. nidulans, A. niger, A. ustus), vrste roda Candida (Candida albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. dubliniensis, C. famata, C. inconspicua, C. lipolytica, C. norvegensis, C. pseudotropicalis), Coccidioides immitis, Fonsecaea pedrosoi te vrste rodova Fusarium, Rhizomucor, Mucor i Rhizopus.
English: Overall efficacy of posaconazole oral suspension at the end of treatment for invasive aspergillosis in comparison to an external control group
Croatian: Tablica 4. Ukupna djelotvornost oralne suspenzije posakonazola na završetku liječenja invazivne aspergiloze u usporedbi s vanjskom kontrolnom skupinom Oralna suspenzija posakonazola
English: Do not switch between taking Posaconazole Accord tablets and posaconazole oral suspension without talking to your doctor or pharmacist because it may result in a lack of efficacy or an increased risk of adverse reactions.
Croatian: Nemojte prijeći s Posakonazol Accord tableta na oralnu suspenziju posakonazola ili obrnuto bez razgovora s liječnikom ili ljekarnikom jer to može dovesti do smanjenja djelotvornosti lijeka i povećanog rizika za pojavu nuspojava.
English: Calcium channel blockers metabolised through CYP3A4 (e.g. diltiazem, verapamil, nifedipine, nisoldipine)
Croatian: Blokatori kalcijevih kanala koji se metaboliziraju putem CYP3A4 (npr. diltiazem, verapamil, nifedipin, nizoldipin)
English: Therefore, trough concentrations that fall in the upper part of the usual therapeutic range should be targeted and careful attention should be paid to clinical signs and symptoms, laboratory parameters and tissue biopsies.
Croatian: Stoga treba ciljati da najniža koncentracija sirolimusa bude u gornjem dijelu uobičajenog raspona terapijskih vrijednosti, te u tom smislu treba pozorno pratiti kliničke znakove i simptome, laboratorijske nalaze i nalaze biopsije tkiva.
English: However, the safety profile of posaconazole between the Black and Caucasian subjects was similar.
Croatian: Ipak, sigurnosni profil posakonazola bio je sličan u ispitanika crne i bijele rase.
English: Limited data on the effect of hepatic impairment (including Child-Pugh C classification of chronic liver disease) on the pharmacokinetics of posaconazole demonstrate an increase in plasma exposure compared to subjects with normal hepatic function, but do not suggest that dose adjustment is necessary (see sections 4.4 and 5.2).
Croatian: Ograničeni podaci o učinku oštećenja funkcije jetre (uključujući kroničnu bolest jetre stadija C prema Child-Pugh klasifikaciji) na farmakokinetiku posakonazola pokazuju povećanu izloženost u plazmi u usporedbi s ispitanicima s normalnom funkcijom jetre, ali ne ukazuju na potrebu prilagodbe doze (vidjeti dijelove 4.4 i 5.2).
English: Monitoring of glucose concentrations is recommended in diabetic patients.
Croatian: Preporučuje se kontrolirati koncentraciju glukoze u bolesnika sa šećernom bolešću.