FrancophonIA/ELRC3.0 huggingface dataset:
English: If Ranexa is used in patients with a combination of several of these factors, monitoring of adverse events should be frequent, the dose reduced, and treatment discontinued, if needed.
Croatian: Ako se Ranexa koristi kod bolesnika s nekoliko od ovih faktora rizika, treba često provoditi praćenje nuspojava, smanjiti dozu ili, ako je potrebno, prekinuti liječenje.
English: Steady state is generally achieved within 3 days of twice-daily dosing.
Croatian: Stanje dinamičke ravnoteže općenito se postiže unutar 3 dana od primjene doze dvaput dnevno.
English: Embryofetal toxicity studies were conducted in rats and rabbits: no effect were noted in rabbit fetuses when mothers were exposed at levels (AUC) of plasma ranolazine similar to expected human levels.
Croatian: Provedena su embriofetalna ispitivanja toksičnosti na štakorima i kunićima: nisu primijećeni učinci u fetusa kunića kada su majke bile izložene razini (AUC) ranolazina u plazmi sličnoj očekivanoj izloženosti u ljudi.
English: If a patient experiences treatment-related adverse events (e.g. dizziness, nausea, or vomiting), downtitration of Ranexa to 500 mg or 375 mg twice daily may be required.
Croatian: Ako bolesnik osjeti nuspojave vezane uz lijek (npr. omaglicu, mučninu ili povraćanje), može biti potrebno postupno smanjenje doze Ranexe na 500 mg ili 375 mg dvaput dnevno.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA PC: {number}
Croatian: JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM
English: The terminal half-life at steady state after oral administration of ranolazine is about 7 hours, due to the absorption rate-limited elimination.
Croatian: Završno poluvrijeme eliminacije u stanju dinamičke ravnoteže nakon oralne primjene ranolazina je oko 7 sati zbog ograničenja eliminacije brzinom apsorpcije.
English: The influence of various factors on the pharmacokinetics of ranolazine was assessed in a population pharmacokinetic evaluation in 928 angina patients and healthy subjects.
Croatian: Utjecaj različitih faktora na farmakokinetiku ranolazina ocijenjen je u procjeni populacijske farmakokinetike na 928 bolesnika s anginom pektoris i zdravih ispitanika.
English: You should stop taking Ranexa and see your doctor immediately if you experience the following symptoms of angioedema, which is a rare condition but can be severe:
Croatian: Trebate prestati uzimati Ranexu i obratiti se liječniku bez odlaganja ako osjetite sljedeće simptome angioedema, što je rijetko stanje, ali može biti teško: • otečeno lice, jezik ili grlo
English: Fertility: In animals, reproduction studies indicated no adverse effects on fertility (see section 5.3).
Croatian: Plodnost: Reproduktivna ispitivanja na životinjama nisu pokazala štetne učinke na plodnost (vidjeti dio 5.3).
English: If the CYP2D6 status of the patient has been determined (e.g. by genotyping) or is previously known to be EM, Ranexa can be used with caution in these patients when they have a combination of several of the above risk factors.
Croatian: Ako je CYP2D6 status bolesnika bio određen (npr. genotipiziranjem) ili je od prije poznato da je bolesnik jaki metabolizator, Ranexa se kod tih bolesnika može koristiti uz oprez ako imaju kombinaciju nekoliko prethodno navedenih faktora rizika.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja galaktoze, potpunim nedostatkom laktaze ili malapsorpcijom glukoze i galaktoze ne bi smjeli uzimati ovaj lijek.
English: Berlin-Chemie AG Glienicker Weg 125 12489 Berlin Germany or
Croatian: Berlin-Chemie AG Glienicker Weg 125 12489 Berlin
English: Ask your doctor for advice if you are breastfeeding.
Croatian: Obratite se svom liječniku za savjet ako dojite.
English: SpA Via R. Follereau 25 24027 Nembro (BG) Italy
Croatian: Follereau 25 24027 Nembro (BG) Italija
English: The AUC of metabolites increased with decreased renal function.
Croatian: AUC metabolita povećavao se sa smanjenjem funkcije bubrega.
English: (E133) and Yellow #5/Tartrazine Aluminium Lake (E102)
Croatian: (E133) i žuta boja #5/Tartazine Aluminium Lake (E102)
English: Carton containing blister strips or carton containing HDPE bottle and bottle label.
Croatian: Kutija koja sadrži blister kartice ili kutija koja sadrži bočicu od polietilena visoke gustoće (HDPE) i naljepnicu na bočici.
English: - certain medicines to treat high levels of cholesterol in the blood (e.g. simvastatin, lovastatin, atorvastatin).
Croatian: - određene lijekove za liječenje visoke razine kolesterola u krvi (npr. simvastatin, lovastatin, atorvastatin).
English: Absorption: The mean absolute bioavailability of ranolazine after oral administration of immediaterelease ranolazine tablets ranged from 35−50%, with large inter-individual variability.
Croatian: Apsorpcija: Srednja apsolutna bioraspoloživost ranolazina nakon peroralne primjene tableta ranolazina s brzim otpuštanjem iznosila je 35−50%, uz veliku individualnu varijabilnost.
English: Ranexa is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled or intolerant to first-line antianginal therapies (such as beta-blockers and/or calcium antagonists).
Croatian: Ranexa je indicirana kod odraslih kao dodatna terapija za simptomatsko liječenje bolesnika sa stabilnom anginom pektoris čija bolest nije odgovarajuće kontrolirana ili koji imaju nepodnošljivost na lijekove prve linije terapije angine (kao što su beta-blokatori i/ili kalcijevi antagonisti).
English: There is a theoretical risk that concomitant treatment of ranolazine with other drugs known to prolong the QTc interval may give rise to a pharmacodynamic interaction and increase the possible risk of ventricular arrhythmias.
Croatian: Postoji teoretski rizik da bi istovremeno liječenje s ranolazinom i drugim lijekovima za koje je poznato da produljuju QTc interval moglo dovesti do farmakodinamičke interakcije i povećati mogući rizik od ventrikularnih aritmija.
English: Low weight: The incidence of adverse events was higher in patients with low weight (≤ 60 kg).
Croatian: Niska tjelesna težina: Incidencija nuspojava bila je veća kod bolesnika niske tjelesne težine (≤ 60 kg).
English: Your doctor may lower your dose or stop treatment with Ranexa.
Croatian: Vaš liječnik može smanjiti dozu ili prekinuti liječenje Ranexom.
English: Magyarország Berlin-Chemie/A.
Croatian: Berlin-Chemie/A.
English: 1, Avenue de la Gare, L-1611 Luxembourg Luxembourg
Croatian: 1, Avenue de la Gare, L-1611 Luxembourg Luksemburg
English: The potential for dose-related adverse events (e.g. nausea, dizziness) may also increase with increased plasma concentrations.
Croatian: Potencijal pojave nuspojava povezanih s dozom (npr. mučnine, omaglice) može se također povećati kod povećanih koncentracija u plazmi.
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), and very rare (< 1/10,000).
Croatian: (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000) i vrlo rijetko
English: The active substance in Ranexa is ranolazine.
Croatian: Djelatna tvar u Ranexi je ranolazin.
English: Rare: throat tightness.
Croatian: Rijetko: stezanje u grlu.
English: Body weight: Compared to subjects weighing 70 kg, exposure was estimated to be about 1.4-fold higher in subjects weighing 40 kg.
Croatian: U usporedbi s ispitanicima s tjelesnom težinom od 70 kg, procjenjuje se da je ekspozicija oko 1,4 puta veća kod ispitanika s tjelesnom težinom od 40 kg.
English: The above precautions are based on the risk in a CYP2D6 PM patient, and are needed when the CYP2D6 status is unknown.
Croatian: Navedene mjere opreza temelje se na riziku kod bolesnika bez aktivnosti CYP2D6, i potrebne su kad je CYP2D6 status nepoznat.
English: Available data suggest that ranolazine is a mild inhibitor of CYP2D6.
Croatian: Raspoloživi podaci upućuju na to da je ranolazin blag inhibitor CYP2D6.
English: In healthy young adults, ranolazine accounts for approximately 13% of the radioactivity in plasma following a single oral 500 mg dose of [
Croatian: Kod zdravih mladih odraslih osoba, na ranolazin otpada 13 % radioaktivnosti u plazmi nakon jednokratne oralne doze od 500 mg [14C]-ranolazina.
English: Ranolazine, via its action to decrease the late sodium current, is considered to reduce these intracellular ionic imbalances during ischaemia.
Croatian: Smatra se da ranolazin, djelujući na smanjenje kasne natrijske struje, smanjuje ove unutarstanične ionske neravnoteže za vrijeme ishemije.
English: These were reported during the Phase 3 clinical development programme, which included a total of 1,030 chronic angina patients treated with Ranexa.
Croatian: Zabilježene su tijekom faze III kliničkog ispitivanja, koja je uključivala ukupno 1030 bolesnika s kroničnom anginom pektoris liječenih Ranexom.
English: In this long term study, acute renal failure was also reported with an incidence less than 1% in placebo and ranolazine patients.
Croatian: U ovom dugoročnom ispitivanju također je zabilježeno akutno zatajenje bubrega s učestalošću manjom od 1% kod bolesnika koji su primali placebo i ranolazin.
English: - If you have any further questions, ask your doctor or pharmacist.
Croatian: Možda ćete je trebati ponovno pročitati.Ako imate dodatnih pitanja, obratite se liječniku ili ljekarniku.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 09 July 2008
Croatian: Datum prvog odobrenja: 09. srpnja 2008.
English: - if you have moderate or severe liver problems.
Croatian: - ako imate umjerene ili teške probleme s jetrom.
English: No dose adjustment is required.
Croatian: Usprkos tome, prilagođavanje doze nije potrebno.
English: This reduces intracellular sodium accumulation and consequently decreases intracellular calcium overload.
Croatian: To smanjuje intracelularno nakupljanje natrija i posljedično smanjuje nakupljanje intracelularnog kalcija.
English: Careful dose titration of Ranexa is recommended in patients treated with P-gp inhibitors.
Croatian: Pažljivo prilagođavanje doze Ranexe preporučuje se kod bolesnika liječenih inhibitorima P-gp-a.
English: Clinical evidence of inhibition of the late sodium current by ranolazine is provided by a significant shortening of the QTc interval and an improvement in diastolic relaxation in an open-label study of 5 patients with a long QT syndrome (LQT3 having the SCN5A ΔKPQ gene mutation).
Croatian: Klinički dokaz inhibicije kasnog protoka natrija pomoću ranolazina nalazi se u značajnom skraćenju QTc intervala i poboljšanju dijastoličke relaksacije u otvorenoj studiji na 5 bolesnika sa sindromom dugog QT (LQT3 sa SCN5A ΔKPQ mutacijom gena).
English: A small proportion of non-Caucasians was included in the controlled clinical studies; therefore, no conclusions can be drawn regarding the effect and safety in non-Caucasians.
Croatian: U kontrolirana klinička istraživanja bio je uključen mali broj bolesnika koji nisu bijele rase pa se zbog toga ne mogu izvoditi zaključci u pogledu učinka i sigurnosti lijeka kod drugih rasa.
English: A renal function study in healthy volunteers demonstrated a reduction in creatinine clearance with no change in glomerular filtration rate consistent with inhibition of renal tubular secretion of creatinine.
Croatian: Ispitivanje bubrežne funkcije kod zdravih dobrovoljaca pokazalo je smanjenje klirensa kreatinina bez promjene brzine glomerularne filtracije što je konzistentno s inhibicijom izlučivanja kreatinina preko bubrežnih tubula.
English: Elderly, renal impairment, and low weight: In general, adverse events occurred more frequently among elderly patients and patients with renal impairment; however, the types of events in these subgroups were similar to those observed in the general population.
Croatian: Stariji bolesnici, bolesnici s oštećenom funkcijom bubrega i bolesnici niske tjelesne težine: Općenito su se nuspojave pojavljivale češće kod starijih bolesnika i bolesnika s oštećenom funkcijom bubrega; međutim, vrste nuspojava kod ovih podskupina bile su slične uočenima u općoj populaciji.
English: CYP3A4 inducers: Rifampicin (600 mg once daily) decreases ranolazine steady-state concentrations by approximately 95%.
Croatian: Induktori CYP3A4: Rifampicin (600 mg jednom dnevno) smanjuje koncentraciju ranolazina u stanju dinamičke ravnoteže za otprilike 95%.
English: Laboratory findings: Small, clinically insignificant, reversible elevations in serum creatinine levels have been observed in healthy subjects and patients treated with Ranexa.
Croatian: Laboratorijski nalazi: Mala, reverzibilna povišenja razine kreatinina u serumu koja nisu klinički značajna uočena su kod zdravih ispitanika i bolesnika liječenih Ranexom.
English: Clearance of ranolazine is dose-dependent, decreasing with increased dose.
Croatian: Klirens ranolazina ovisan je o dozi i smanjuje se kod povećanja doze.
English: - certain medicines used to prevent transplanted organ rejection (e.g. tacrolimus, ciclosporin, sirolimus, everolimus) as your doctor may decide to change the dose of this medicine while you are taking Ranexa.
Croatian: - određene lijekove za sprječavanje odbacivanja transplantiranog organa (npr. takrolimus, ciklosporin, sirolimus, everolimus), jer liječnik može odlučiti promijeniti dozu tog lijeka dok uzimate Ranexu.
English: Ranolazine may have some antianginal effects by inhibition of the late sodium current in cardiac cells.
Croatian: Ranolazin može imati određene antianginalne učinke inhibicijom kasne natrijske struje u srčanim stanicama.
English: However, men and women had similar reductions in frequency of angina attacks and nitroglycerin consumption.
Croatian: Međutim, i kod žena i kod muškaraca došlo je do sličnog smanjenja učestalosti napadaja angine pektoris i korištenja nitroglicerina.
English: In a second study, ERICA, Ranexa was added to treatment with amlodipine 10 mg once daily (the maximum labelled dose).
Croatian: U drugom istraživanju, ERICA, Ranexa je bila dodatni lijek, uz amlodipin 10 mg jednom dnevno (maksimalna doza propisana uputom).
English: Therefore, caution should be observed when treating patients with a history of congenital or a family history of long QT syndrome, in patients with known acquired QT interval prolongation, and in patients treated with drugs affecting the QTc interval (see section 4.5 also).
Croatian: Zbog toga treba postupati uz oprez kod bolesnika s urođenim ili obiteljski prisutnim sindromom dugog QT intervala u povijesti bolesti, kod bolesnika s poznatim stečenim produljenjem QT intervala i kod bolesnika liječenih lijekovima koji utječu na QTc interval (vidjeti također dio 4.5).
English: Deutschland Berlin-Chemie AG Tel: +49 (0) 30 67070
Croatian: Berlin-Chemie AG Tel: +49 (0) 30 67070
English: Menarini - Von Heyden GmbH Leipziger Straβe 7-13
Croatian: Leipziger Straβe 7-13
English: The exposure of other OCT2 substrates, including but not limited to pindolol and varenicline, may be affected to a similar degree.
Croatian: Izloženost drugim OCT2 supstratima, uključujući pindolol i vareniklin, može biti promijenjena na sličan način.
English: Grapefruit juice is also a potent CYP3A4 inhibitor.
Croatian: Sok od grejpa je također snažan inhibitor CYP3A4.
English: Following oral administration of a single 500 mg dose of
Croatian: Nakon peroralne primjene jednokratne doze od 500 mg
English: Tolerance to ranolazine did not develop during treatment and a rebound increase in angina attacks was not observed following abrupt discontinuation.
Croatian: Tijekom liječenja se nije razvila tolerancija na ranolazin, a nakon naglog prekida terapije nije došlo do povećane učestalosti napadaja angine pektoris.
English: In this study, exercise duration was longest in the 1500 mg group; however, there was a disproportional increase in side effects, and the 1500 mg dose was not studied further.
Croatian: U ovom istraživanju trajanje opterećenja bilo je najdulje kod skupine koja je primala 1500 mg; međutim, postojalo je neproporcionalno povećanje učestalosti nuspojava, tako da korištenje doze od
English: CYP2D6 inhibitors: Ranolazine is partially metabolised by CYP2D6; therefore, inhibitors of this enzyme may increase plasma concentrations of ranolazine.
Croatian: Inhibitori CYP2D6: CYP2D6 djelomično metabolizira ranolazin; stoga inhibitori ovog enzima mogu povećati koncentracije ranolazina u plazmi.
English: In this study, there was a higher reporting rate for congestive heart failure in the ranolazine group (2.2% vs 1.0% in placebo).
Croatian: U ovom je ispitivanju bila veća stopa prijavljivanja kongestivnog srčanog zatajenja u skupini na ranolazinu (2,2% u odnosu na 1,0% na placebu).
English: - certain medicines to treat depression (bupropion), psychosis, HIV infection (efavirenz), or cancer (cyclophosphamide).
Croatian: - određene lijekove za liječenje depresije (bupropion), psihoze, HIV infekcije (efavirenz) ili karcinoma (ciklofosfamid).
English: Post-natal mortality of pups was not recorded when the exposure of nursing mothers was 1.3 fold higher than in expected humans, whereas at 3-fold higher exposure post-natal mortality was recorded, concomitant with evidence of milk excretion of ranolazine in rats.
Croatian: Postnatalni mortalitet okota nije zabilježen kada je izloženost majki koje doje bila 1,3 puta veća od očekivane izloženosti u ljudi, dok je pri izloženosti koja je bila 3 puta veća zabilježen postnatalni mortalitet okota, istodobno s dokazom izlučivanja ranolazina u mlijeko štakora.
English: In rats, no effects in fetuses was noted when mothers were exposed to 2-fold greater levels (AUC) than expected in humans, whereas decreased fetal weight and reduced ossification were observed when the exposure of mothers was 7.5-fold than those obtained in humans.
Croatian: U štakora, nisu primijećeni učinci na fetuse kada su majke bile izložene 2 puta većoj razini (AUC) od očekivane izloženosti u ljudi, ali su primijećeni smanjena težina fetusa i smanjena osifikacija kada je izloženost majki bila 7,5 puta veća od izloženosti u ljudi.
English: The AUC of one pharmacologically active ranolazine metabolite was 5-fold increased in patients with severe renal impairment.
Croatian: AUC jednog farmakološki aktivnog metabolita ranolazina bio je povećan 5 puta kod bolesnika s teškim oštećenjem funkcije bubrega.
English: The Seattle Angina Questionnaire showed significant effects on several dimensions, including angina frequency (p < 0.001), compared to placebo-treated patients.
Croatian: Angina upitnik pokazao je značajan učinak na nekoliko razina, uključujući učestalost pojave angine pektoris (p < 0,001) u odnosu na bolesnike koji su primali placebo.
English: Approximately 62% of ranolazine is bound to plasma proteins, and therefore, complete clearance by haemodialysis is unlikely.
Croatian: Oko 62% ranolazina se veže na proteine plazme i zbog toga potpun klirens hemodijalizom nije vjerojatan.
English: Improvement of exercise duration was statistically significant compared to placebo for all three doses of ranolazine from 24 seconds at 500 mg twice daily to 46 seconds at 1500 mg twice daily, showing a dose-related response.
Croatian: Produljenje trajanja opterećenja bilo je statistički značajno u usporedbi s placebom kod sve tri doze ranolazina, od 24 sekunde kod doze od 500 mg dvaput dnevno do 46 sekundi kod doze od 1500 mg dvaput dnevno, pokazujući odnos doza-odgovor.
English: Down-titration of Ranexa may be required (see sections 4.2 and 4.4).
Croatian: Može biti potrebno postupno smanjenje doze Ranexe (vidjeti dijelove 4.2 i 4.4).
English: Rare: impaired hearing.
Croatian: Rijetko: slabiji sluh.
English: Ranexa should not be used during breast-feeding.
Croatian: Ranexa se ne bi smjela primjenjivati tijekom dojenja.
English: The influence of dialysis on the pharmacokinetics of ranolazine has not been evaluated.
Croatian: Utjecaj dijalize na farmakokinetiku ranolazina nije procjenjivan.
English: Rare: pancreatitis, erosive duodenitis, oral hypoaesthesia.
Croatian: Rijetko: pankreatitis, erozivni duodenitis, oralna hipoestezija.
English: Chronic toxicity studies in rats indicated that treatment was associated with adrenal changes at exposures slightly greater than those seen in clinical patients.
Croatian: Ispitivanja kronične toksičnosti kod štakora upućivala su na to da je liječenje povezano s promjenama na nadbubrežnoj žlijezdi kod ekspozicije neznatno višoj od one koja postoji kod kliničkih bolesnika.
English: The starting dose for adults is one 375 mg tablet twice a day.
Croatian: Početna doza za odrasle je jedna tableta od 375 mg dvaput dnevno.
English: Atorvastatin: Ranexa 1000 mg twice daily increased Cmax and AUC of atorvastatin 80 mg once daily by 1.4- and 1.3 -fold, respectively and changed the Cmax and AUC of atorvastatin metabolites less than 35%.
Croatian: Atorvastatin: Ranexa primijenjena u dozi od 1000 mg dvaput dnevno povećala je Cmax i AUC atorvastatina primijenjenog u dozi od 80 mg jednom dnevno 1,4 odnosno 1,3 puta i promijenila je Cmax i AUC metabolita atorvastatina manje od 35%.
English: Effects of other medicinal products on ranolazine
Croatian: Djelovanje drugih lijekova na ranolazin
English: The elimination half-life is about 2−3 hours after intravenous administration.
Croatian: 2−3 sata nakon intravenske primjene.
English: The adverse events, considered to be at least possibly related to treatment, are listed below by body system, organ class, and absolute frequency.
Croatian: Nuspojave, za koje se smatra da je moguća povezanost s liječenjem, navedene su prema klasifikaciji organskih sustava i apsolutnoj učestalosti.
English: In subjects with severe renal impairment (creatinine clearance 10-30 ml/min), a 1.3- to 1.8-fold increase in ranolazine exposure was estimated.
Croatian: Kod ispitanika s teškim oštećenjem bubrega (klirens kreatinina 10-30 ml/min), procijenjeno je da postoji povećanje ekspozicije ranolazinu od 1,3 do 1,8 puta.
English: Therefore the exposure to metoprolol or other CYP2D6 substrates (e.g. propafenone and flecainide or, to a lesser extent, tricyclic antidepressants and antipsychotics) may be increased during co-administration with Ranexa, and lower doses of these medicinal products may be required.
Croatian: Stoga ekspozicija metoprololu ili drugim supstratima CYP2D6 (npr. propafenonu i flekainidu ili, u manjoj mjeri, tricikličkim antidepresivima i antipsihoticima) može biti povećana kod istovremene primjene Ranexe pa mogu biti potrebne manje doze tih lijekova.
English: The results showed that exercise duration was 31 seconds longer in ranolazine patients versus placebo patients (p = 0.002).
Croatian: Rezultati istraživanja pokazali su da je trajanje opterećenja bilo 31 sekundu dulje kod bolesnika koji su primali ranolazin u odnosu na bolesnike koji su primali placebo (p = 0,002).
English: The mean steady-state volume of distribution (Vss) is about 180 l.
Croatian: Srednji volumen raspodjele (Vss) u stanju dinamičke ravnoteže je oko 180 l.
English: Breast-feeding: It is unknown whether ranolazine is excreted in human breast milk.
Croatian: Dojenje: Nije poznato izlučuje li se ranolazin u majčino mlijeko.
English: Concomitant treatment with ketoconazole 200 mg twice daily increased the AUC of ranolazine by 3.0- to 3.9-fold during ranolazine treatment.
Croatian: Istovremeno liječenje ketokonazolom 200 mg dvaput dnevno povećalo je površinu ispod krivulje (AUC) ranolazina 3,0 do 3,9 puta tijekom liječenja ranolazinom.
English: Rare: angioedema, allergic dermatitis, urticaria, cold sweat, rash.
Croatian: Rijetko: angioedem, alergijski dermatitis, urtikarija, hladni znoj, osip.
English: Distribution: Approximately 62% of ranolazine is bound to plasma proteins, mainly alpha-1 acid glycoprotein and weakly to albumin.
Croatian: Distribucija: Oko 62% ranolazina veže se na proteine plazme, prvenstveno na alfa-1 kiseli glikoprotein i slabo na albumin.
English: Polyvinyl alcohol-part hydrolyzed Iron oxide yellow (E172) Iron oxide red (E172) Talc
Croatian: makrogol poli(vinilni alkohol)-djelomično hidroliziran željezov oksid, žuti (E172) željezov oksid, crveni (E172) talk