FrancophonIA/ELRC3.0 huggingface dataset:
English: Antidepressants Amitriptyline, fluoxetine, imipramine, nortriptyline, paroxetine, sertraline
Croatian: Antidepresivi Amitriptilin, fluoksetin, imipramin, nortriptilin, paroksetin, sertralin
English: • swelling of the hands and feet
Croatian: • oticanje dlanova i stopala
English: Based on data for other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally.
Croatian: Na temelju podataka o drugim inhibitorima CYP3A4, očekuje se da bi koncentracije midazolama u plazmi bile značajno veće pri njegovoj oralnoj primjeni.
English: If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, contact your doctor, pharmacist, Accident and Emergency department or if it is urgent get immediate medical help.
Croatian: Pogorša li se bilo koja nuspojava, ili ako zamijetite nuspojavu koja nije navedena u ovoj uputi, molimo javite se svome liječniku, ljekarniku ili hitnoj službi, a ako je riječ o hitnom slučaju, odmah potražite liječničku pomoć.
English: The pharmacokinetic parameters observed with various dosing schemes of ritonavir alone are shown in the table below.
Croatian: Farmakokinetički pokazatelji praćeni pri različitim shemama doziranja ritonavira samog prikazani su u tablici niže.
English: 6.6 Special precautions for disposal No special requirements.
Croatian: 6.6 Posebne mjere za zbrinjavanje i druga rukovanja lijekom Nema posebnih zahtjeva.
English: Increased risk of tumor lysis syndrome at the dose initiation and during the dose-titration phase (see section 4.5).
Croatian: Povećan rizik od sindroma tumorske lize pri uvođenju liječenja i tijekom razdoblja titracije doze (vidjeti dio 4.5).
English: Adverse reactions from clinical trials and post-marketing experience in adult patients The most frequently reported adverse drug reactions among patients receiving ritonavir alone or in combination with other antiretroviral drugs were gastrointestinal (including diarrhoea, nausea, vomiting, abdominal pain (upper and lower)), neurological disturbances (including paraesthesia and oral paraesthesia) and fatigue/asthenia.
Croatian: Nuspojave iz kliničkih ispitivanja i iz postmarketinškog praćenja kod odraslih bolesnika Najčešće zabilježene nuspojave među bolesnicima koji su uzimali ritonavir sam ili u kombinaciji s drugim antiretrovirusnim lijekovima bili su poremećaji probavnog sustava (uključujući proljev, mučninu, povraćanje, bol u gornjem i donjem abdomenu, neurološki poremećaji (uključujući paresteziju i oralnu paresteziju) i umor/astenija.
English: Plasma concentrations of ritonavir after administration of a single 100 mg dose tablet are similar to the 100 mg soft gelatin capsule under fed conditions.
Croatian: Koncentracije ritonavira u plazmi nakon primjene jednokratne doze u tableti od 100 mg bile su slične onima nakon primjene doze od 100 mg u mekoj želatinskoj kapsuli, uzetima s hranom.
English: Anorexia, flatulence, mouth ulcer, gastrointestinal haemorrhage, gastroesophageal reflux disease, pancreatitis
Croatian: Anoreksija, flatulencija, ulceracija usne šupljine, gastrointestinalno krvarenje, gastroezofagealna refluksna bolest, pankreatitis
English: The mean changes from baseline in PR interval ranged from 11.0 to 24.0 msec in the 12 hour interval post dose.
Croatian: Srednje vrijednosti promjena PR-intervala u odnosu na početne kretale su se u rasponu od 11,0 do 24,0 msec tijekom razdoblja od 12 sati nakon uzimanja doze.
English: Ritonavir can pass into breast milk.
Croatian: Ritonavir se može izlučiti u majčino mlijeko.
English: The tablets should be swallowed whole and not chewed, broken or crushed.
Croatian: Tablete se moraju progutati cijele i ne smiju se žvakati, lomiti ni drobiti.
English: Patients with impaired liver function
Croatian: Bolesnici s oštećenom funkcijom jetre
English: LIST OF EXCIPIENTS High in sodium - see leaflet for further information.
Croatian: POPIS POMOĆNIH TVARI Visoki sadržaj natrija - za dodatne informacije vidjeti uputu o lijeku.
English: Across dose groups, ritonavir oral clearance (CL/F/m2) was approximately 1.5 to 1.7 times faster in paediatric patients above 2 years of age than in adult subjects.
Croatian: Usporedba skupina prema primljenim dozama pokazala je da je klirens oralno primijenjenog ritonavira (CL/F/m²) bio oko 1,5 do 1,7 puta brži u pedijatrijskih bolesnika starijih od 2 godine negoli u odraslih ispitanika.
English: 117 Allée des Parcs, Saint-Priest, 69800, France
Croatian: 117 Allée des Parcs, Saint-Priest, 69800, Francuska
English: Herbal preparations containing St John's wort (Hypericum perforatum) due to the risk of decreased plasma concentrations and reduced clinical effects of ritonavir (see section 4.5).
Croatian: Biljni pripravci koji sadržavaju gospinu travu (Hypericum perforatum), zbog rizika od smanjenih koncentracija u plazmi i slabijih kliničkih učinaka ritonavira (vidjeti dio 4.5).
English: Ritonavir is not a cure for HIV infection or AIDS.
Croatian: - Ritonavir nije lijek za izlječenje HIV-infekcije ni AIDS-a.
English: Tissue to plasma ratios of approximately 1 measured in rat lymph nodes suggests that ritonavir distributes into lymphatic tissues.
Croatian: Omjer tkivo: plazma od oko 1, izmjeren u limfnim čvorovima štakora, upućuje na to da se ritonavir distribuira u limfna tkiva.
English: Co-administration of delamanid with a strong inhibitor of CYP3A (ritonavir) may increase exposure to delamanid metabolite, which has been associated with QTc prolongation.
Croatian: Istodobna primjena delamanida sa snažnim inhibitorom CYP3A (ritonavirom) može povisiti izloženost metabolitu delamanida, koji je povezan s produljenjem QTc intervala.
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymtomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Croatian: U bolesnika s HIV-infekcijom i teškom imunodeficijencijom u vrijeme uvođenja kombiniranog antiretrovirusnog liječenja (CART, engl. combination antiretroviral therapy) može se javiti upalna reakcija na asimptomatske ili rezidualne oportunističke patogene i prouzročiti ozbiljna klinička stanja ili pogoršati simptome.
English: Digoxin levels should be monitored more intensively than usual during this period, with dose adjustments made, as necessary, based on clinical, electrocardiographic and digoxin level findings.
Croatian: Razine digoksina treba tijekom tog razdoblja provjeravati češće nego inače, a dozu prilagođavati prema potrebi, ovisno o kliničkom i elektrokardiografskom nalazu te o razinama digoksina.
English: HCV Direct Acting Antiviral Glecaprevir/pibrentasvir
Croatian: Direktno djelujući antivirotici za liječenje HCV-a Glekaprevir/pibrentasvir
English: Saquinavir/ritonavir should not be given together with rifampicin, due to the risk of severe hepatotoxicity (presenting as increased hepatic transaminases) if the three medicines are given together (see section 4.5).
Croatian: Sakvinavir/ritonavir se ne smiju davati istodobno s rifampicinom zbog rizika od teške hepatotoksičnosti (koja se očituje porastom vrijednosti jetrenih transaminaza) ako se ta tri lijeka daju istodobno (vidjeti dio 4.5).
English: These data indicate no increase in the rate of birth defects compared to rates observed in population-based birth defect surveillance systems.
Croatian: Prema tim podacima, stopa porođajnih defekata nije bila veća od one zabilježene u općoj populaciji.
English: Increased fexofenadine levels may lessen over time as induction develops.
Croatian: Povišene razine feksofenadina mogu se s vremenom, s razvojem indukcije, sniziti.
English: Ritonavir is an orally active peptidomimetic inhibitor of the HIV-1 and HIV-2 aspartyl proteases.
Croatian: Ritonavir je oralno djelatni peptidomimetički inhibitor aspartil-proteaza virusa HIV-1 i HIV-2.
English: Proton pump inhibitors and H2-receptor antagonists Proton pump inhibitors and H2-receptor antagonists (e.g. omeprazole or ranitidine) may reduce concentrations for co-administered protease inhibitors.
Croatian: Inhibitori protonske crpke i antagonisti H2-receptora Inhibitori protonske crpke i antagonisti H2-receptora (npr. omeprazol i ranitidin) mogu smanjiti koncentracije istodobno primijenjenih inhibitora proteaza.
English: Rare reports of 2nd or 3rd degree atrioventricular block in patients with underlying structural heart disease and pre-existing conduction system abnormalities or in patients receiving medicinal products known to prolong the PR interval (such as verapamil or atazanavir) have been reported in patients receiving ritonavir.
Croatian: Bilo je rijetkih prijava atrioventrikularnog bloka 2. i 3. stupnja u bolesnika sa strukturnom bolešću srca u podlozi i u onih s već prisutnim nenormalnostima provodnog sustava, te u bolesnika koji su primali lijekove za koje se zna da produžuju PR-interval (npr. verapamil i atazanavir), a primali su ritonavir.
English: Caution should be exercised in administering afatinib with ritonavir (refer to the afatinib SmPC).
Croatian: Potreban je oprez kada se afatinib primjenjuje zajedno s ritonavirom (vidjeti Sažetak opisa svojstava lijeka za afatinib).
English: Clinical investigation in humans has revealed no clinically significant alteration in thyroid function tests.
Croatian: Klinička ispitivanja u ljudi nisu pokazala klinički značajne promjene nalaza funkcijskih pretraga štitnjače.
English: Clarithromycin doses greater than 1 g per day should not be co-administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer.
Croatian: Klaritromicin u dozama većima od 1 g na dan ne treba davati istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom ni kao farmakokinetičkim pojačivačem.
English: The maximum mean (95% upper confidence bound) difference in QTcF from placebo was 5.5 (7.6) for 400 mg twice daily ritonavir.
Croatian: Maksimalna razlika srednje vrijednosti (gornja granica 95%tnog intervala pouzdanosti) QTcF-a u odnosu na placebo iznosila je 5,5 (7,6) pri dozi ritonavira od
English: Developmental toxicity observed in rats (embryolethality, decreased foetal body weight and ossification delays and visceral changes, including delayed testicular descent) occurred mainly at a maternally toxic dosage.
Croatian: Razvojna toksičnost u štakora (embrioletalnost, smanjena tjelesna težina fetusa, odgođeno okoštavanje i visceralne promjene, uključujući odgođeno spuštanje testisa) zamijećena je uglavnom pri maternalno toksičnim dozama.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/17/1242/004
Croatian: 12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/17/1242/004
English: Concomitant use of ritonavir and fluticasone or other glucocorticoids that are metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section 4.5).
Croatian: Istodobna primjena ritonavira s flutikazonom ili ostalim glukokortikoidima koji se metaboliziraju putem CYP3A4 se ne preporučuje, osim ako očekivana korist od liječenja ne nadmašuje rizik os sistemnih učinaka kortikosteroida, uključujući Cushingov sindrom i supresiju nadbubrežnih žlijezda (vidjeti dio 4.5).
English: Patients should not remain on 300 mg twice daily for more than 3 days.
Croatian: Bolesnika se na dozi od 300 mg na dan ne smije ostaviti duže od tri dana.
English: Ritonavir was noted to be extensively metabolised by the hepatic cytochrome P450 system, primarily by the CYP3A isozyme family and to a lesser extent by the CYP2D6 isoform.
Croatian: Zabilježeno je da se ritonavir opsežno metabolizira sustavom jetrenog citokroma P450, prvenstveno skupinom izoenzima CYP3A, a u manjem stupnju izoformom CYP2D6.
English: Increased urination, renal impairment (e.g. oliguria, elevated creatinine)
Croatian: Povećano mokrenje, oštećenje bubrega (npr. oligurija, povišen kreatinin)
English: Elevated norpethidine concentrations may increase the risk of CNS effects (e.g., seizures), see section 4.3.
Croatian: Povećane koncentracije norpetidina mogu povećati rizik od učinaka na CNS (npr. od napadaja); vidjeti dio 4.3.
English: Ritonavir should be used with caution in such patients (see section 5.1).
Croatian: Tim bolesnicima ritonavir treba davati oprezno (vidjeti dio 5.1).
English: Hypersensitivity including urticaria, and face oedema
Croatian: Preosjetljivost, uključujući urtikariju i edem lica.
English: The continuation of ritonavir therapy should be evaluated by viral load because of the possibility of the emergence of resistance as described under section 4.1.
Croatian: Opravdanost daljnjeg liječenja ritonavirom valja procijeniti na temelju određivanja broja virusnih jedinica jer postoji mogućnost pojave rezistencije, kao što je opisano u dijelu 4.1. Terapijske indikacije.
English: All thyroid changes were reversible upon discontinuation of ritonavir.
Croatian: Sve promjene na štitnjači nestale su nakon obustave ritonavira.
English: The enzyme-modulating effect of ritonavir may be dose dependent.
Croatian: Utjecaj ritonavira na enzimsku aktivnost može ovisiti o dozi.
English: Renal changes including tubular degeneration, chronic inflammation and proteinurea were noted in rats and are felt to be attributable to species-specific spontaneous disease.
Croatian: U štakora su uočene promjene na bubrezima, uključujući degeneraciju bubrežnih kanalića, kroničnu upalu i proteinuriju, za koje se misli da ih se može pripisati spontanoj bolesti specifičnoj za određenu vrstu.
English: Clinical pharmacodynamic data
Croatian: Klinički podaci o farmakodinamici
English: Medicinal products that affect ritonavir levels
Croatian: Lijekovi koji utječu na razine ritonavira
English: Ritonavir concentrations obtained after 350 to 400 mg/m2 twice daily in paediatric patients were comparable to those obtained in adults receiving 600 mg (approximately 330 mg/m2) twice daily.
Croatian: Koncentracije ritonavira izmjerene nakon primjene doza od 350 do 400 mg/m² dva puta na dan pedijatrijskim bolesnicima bile su usporedive s onima izmjerenima u odraslih koji su uzimali 600 mg (oko 330 mg/m²) dva puta na dan.
English: Patients who exhibit these signs or symptoms should be evaluated and ritonavir therapy should be discontinued if a diagnosis of pancreatitis is made (see section 4.8).
Croatian: Bolesnike u kojih se jave ti znaci ili simptomi treba obraditi, a ako se postavi dijagnoza pankreatitisa, liječenje ritonavirom treba obustaviti (vidjeti dio 4.8).
English: In patients who are already taking ritonavir when digoxin is introduced, digoxin should be introduced more gradually than usual.
Croatian: Kada se digoksin uvodi bolesnicima koji već uzimaju ritonavir, digoksin treba uvoditi postupnije nego inače.
English: Anticancer agents Afatinib
Croatian: Protutumorski lijekovi Afatinib
English: Adjustment to the dose of buprenorphine or ritonavir may therefore not be necessary when the two are dosed together.
Croatian: Stoga nije nužno prilagođavanje doze ni buprenorfina ni ritonavira kada se ta dva lijeka daju istodobno.
English: In a clinical study investigating the interaction of rifampicin 600 mg once daily and saquinavir 1,000 mg with ritonavir 100 mg twice daily in healthy volunteers, severe hepatocellular toxicity with transaminase elevations up to > 20-fold the upper limit of normal after 1 to 5 days of co-administration was noted.
Croatian: U kliničkom ispitivanju interakcija rifampicina 600 mg jedanput na dan i sakvinavira 1000 mg s ritonavirom 100 mg dva puta na dan u zdravih dobrovoljaca uočena je hepatocelularna toksičnost s porastom vrijednosti transaminaza do > 20 puta iznad gornje granice normale nakon 1 - 5 dana od početka istodobne primjene.
English: Treatment should be initiated at 300 mg (3 tablets) twice daily for a period of three days and increased by 100 mg (1 tablet) twice daily increments up to 600 mg twice daily over a period of no longer than 14 days.
Croatian: Liječenje treba početi dozom od 300 mg (tri tablete) dva puta na dan tijekom tri dana, a potom dozu tijekom razdoblja ne dužeg od 14 dana povećavati za po 100 mg (jedna tableta) dva puta na dan sve do 600 mg dva puta na dan.
English: Adverse reactions in clinical studies and post-marketing in adult patients System Order Class
Croatian: Nuspojave prijavljene u kliničkim ispitivanjima i nakon stavljanja lijeka u promet Sustav organa
English: Co-administration of voriconazole and ritonavir dosed as a pharmacokinetic enhancer should be avoided, unless an assessment of the benefit/risk to the patient justifies the use of voriconazole.
Croatian: Primjenu vorikonazola istodobno s ritonavirom doziranim kao farmakokinetičkim pojačivačem treba izbjegavati, osim ako procjena omjera korist/rizik za bolesnika opravdava primjenu vorikonazola.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Croatian: Bolesnici s hepatitisom B ili C koji primaju kombinirano antiretrovirusno liječenje izloženi su većem riziku od teških i potencijalno smrtnih hepatalnih nuspojava.
English: Ritonavir Mylan is used by children 2 years of age or older, adolescents and adults who are infected with HIV, the virus which causes AIDS.
Croatian: Ritonavir Mylan je namijenjen za liječenje djece u dobi od 2 godine ili starije, adolescenata i odraslih koji su zaraženi HIV-om, tj. virusom koji uzrokuje sindrom stečene imunodeficijencije (AIDS; engl. acquired immunodeficiency syndrome).
English: Because ritonavir is highly protein bound it is unlikely that it will be significantly removed by haemodialysis or peritoneal dialysis.
Croatian: Budući da se ritonavir velikim dijelom veže na proteine, nije vjerojatno da bi se u znatnijem opsegu mogao ukloniti hemodijalizom ni peritonealnom dijalizom.
English: In the absence of pharmacokinetic studies in patients with stable severe hepatic impairment (Child Pugh Grade C) without decompensation, caution should be exercised when ritonavir is used as a pharmacokinetic enhancer as increased levels of the co-administered PI may occur.
Croatian: Budući da nisu provedena ispitivanja farmakokinetike u bolesnika sa stabilnim teškim oštećenjem jetrene funkcije (Child Pugh stupanj C) bez dekompenzacije, nužan je oprez kada se ritonavir daje kao farmakokinetički pojačivač, jer se mogu povisiti razine istodobno primijenjenog inhibitora proteaza (IP).
English: Human experience of acute overdose with ritonavir is limited.
Croatian: Iskustva s predoziranjem ritonavirom u ljudi su ograničena.
English: 500 q12 h ↓ 20%/↑ 20% ↔ Dose alteration of sulfamethoxazole/trimethoprim during concomitant ritonavir therapy should not be necessary.
Croatian: 500 svakih 12 h ↓ 20% / ↑ 20% ↔ Mijenjanje doze sulfametoksazola/trimetoprima nije nužno pri njihovoj istodobnoj primjeni s ritonavirom.
English: A controlled study completed in 1996 with ritonavir as add-on therapy in HIV-1 infected patients extensively pre-treated with nucleoside analogues and baseline CD4 cell counts ≤ 100 cells/μl showed a reduction in mortality and AIDS defining events.
Croatian: Kontrolirano ispitivanje dovršeno 1996. godine, s ritonavirom kao dopunskim lijekom u liječenju bolesnika s HIV-1 infekcijama prethodno opsežno liječenima analozima nukleozida i s brojem CD4stanica na početku ispitivanja ≤ 100/µl, pokazalo je smanjenje stope smrtnosti i događaja kojima se definira AIDS.
English: • difficulty paying attention
Croatian: • poteškoće u koncentraciji
English: Therefore, ritonavir should not be co-administered with orally administered midazolam (see section 4.3), whereas caution should be used with co-administration of ritonavir and parenteral midazolam.
Croatian: Stoga se ritonavir ne smije davati istodobno s midazolamom koji se uzima oralno (vidjeti dio 4.3), a pri korištenju ritonavira istodobno s midazolamom za parenteralnu primjenu nužan je oprez.
English: Patients with chronic diarrhoea or malabsorption
Croatian: Bolesnici s kroničnim proljevom ili s malapsorpcijom
English: Dose of Coadministered Medicinal Products (mg)
Croatian: Doza istodobno primijenjenog lijeka (mg)
English: Muscle pain, tenderness or weakness, particularly in combination with antiretroviral therapy including protease inhibitors and nucleoside analogues.
Croatian: - Bol, osjetljivost ili slabost mišića, osobito u kombinaciji s uzimanjem antiretrovirusnih lijekova, uključujući inhibitore proteaza i analoge nukleozida.
English: Ritonavir 100 mg twice daily with saquinavir 1,000 mg twice daily provides saquinavir systemic exposure over 24 hours similar to or greater than those achieved with saquinavir 1,200 mg three times daily without ritonavir.
Croatian: Ritonavir 100 mg dva puta na dan sa sakvinavirom 1000 mg dva puta na dan osigurava sistemnu izloženost sakvinaviru tijekom 24 sata sličnu ili veću od one koja se postiže sakvinavirom u dozi od 1200 mg triput na dan bez ritonavira.
English: The pharmacokinetics of ritonavir during multiple dose regimens were studied in non-fasting HIV-infected adult volunteers.
Croatian: Farmakokinetika ritonavira tijekom višekratnog doziranja ispitana je u odraslih dobrovoljaca zaraženih HIV-om koji nisu bili natašte.
English: Lipid-modifying agents Lomitapide
Croatian: Lijekovi za modifikaciju lipida Lomitapid
English: Events noted as having frequency not known were identified via post-marketing surveillance.
Croatian: Događaji nepoznate učestalosti su oni prijavljeni praćenjem nakon stavljanja lijeka u promet.
English: Concentrations of colchicine are expected to increase when co-administered with ritonavir.
Croatian: Očekuju se povećane koncentracije kolhicina pri istodobnoj primjeni s ritonavirom.
English: Since increased concentrations of lovastatin and simvastatin may predispose patients to myopathies, including rhabdomyolysis, the combination of these medicinal products with ritonavir is contraindicated (see section 4.3).
Croatian: Budući da povećane koncentracija lovastatina i simvastatina mogu u bolesnika izazvati sklonost k pojavi miopatija, uključujući rabdomiolizu, kombinacija tih lijekova s ritonavirom je kontraindicirana (vidjeti dio 4.3).
English: If Ritonavir Mylan is taken in combination with other antiretroviral medicines, it is important that you also carefully read the leaflets that are provided with these other medicines.
Croatian: Važne informacije - Ako Ritonavir Mylan uzimate u kombinaciji s drugim antiretrovirusnim lijekovima, važno je da pažljivo pročitate i upute o lijeku priložene tim drugim lijekovima.
English: Ritonavir Mylan film-coated tablets should be swallowed whole and not chewed, broken or crushed.
Croatian: Ritonavir Mylan filmom obložene tablete moraju se progutati cijele i ne smiju se žvakati, lomiti ni drobiti.
English: There have been reports of muscle pain, tenderness or weakness, particularly when taking medicines to lower cholesterol in combination with antiretroviral therapy, including protease inhibitors and nucleoside analogues.
Croatian: Bilo je prijava boli, osjetljivosti i slabosti u mišićima, posebno pri uzimanju lijekova za snižavanje kolesterola u kombinaciji s antiretrovirusnim lijekovima, uključujući inhibitore proteaza i analoge nukleozida.
English: Ritonavir adversely interacts with oral contraceptives (OCs).
Croatian: Ritonavir ima nepoželjne interakcije s oralnim kontraceptivima.
English: 100q12h ↓ 39% ↓ 24% Concomitant use of ritonavir dosed as an antiretroviral agent and voriconazole is contraindicated due to reduction in voriconazole concentrations (see section 4.3).
Croatian: 100 svakih 12h↓39% ↓ 24% Primjena ritonavira kao antiretrovirusnog lijeka istodobno s vorikonazolom je kontraindicirana zbog smanjenja koncentracija vorikonazola (vidjeti dio 4.3).
English: Some patients taking ritonavir can develop serious problems with their pancreas.
Croatian: U nekih se bolesnika koji uzimaju ritonavir mogu javiti ozbiljne poteškoće s gušteračom.