FrancophonIA/ELRC3.0 huggingface dataset:
English: - if you are allergic to ketoconazole and/or to any imidazole antifungal medicine, or to any of the other ingredients of this medicine (listed in section 6) - if you have liver problems - if you are pregnant - if you are breastfeeding - if you have a history of an irregular heart beat - if you are taking any of the following medicines:
Danish: - hvis du har problemer med leveren - hvis du er gravid - hvis du ammer - hvis du har eller har haft uregelmæssig hjerterytme - hvis du tager et eller flere af de følgende lægemidler:
English: Ketoconazole HRA with alcohol
Danish: Ketoconazole HRA med alkohol
English: Potential ↑in plasma concentrations of alfentanil and fentanyl
Danish: Potentiel ↑ i plasmakoncentrationen af alfentanil og fentanyl.
English: Medicinal products affecting gastric acidity impair the absorption of ketoconazole (see section 4.4).
Danish: Lægemidler, der påvirker ventriklens surhedsgrad, nedsætter absorptionen af ketoconazol (se pkt.
English: Menstrual disorder, azoospermia, erectile dysfunction, gynaecomastia
Danish: Menstruationsforstyrrelser, azoospermi, erektil dysfunktion, gynækomasti
English: - A dose increase of 200 mg/day every 7 to 28 days may be considered if urinary free cortisol and/or plasma cortisol levels are above the normal range, as long as the dose is tolerated by the patient;
Danish: - Så længe patienten tåler dosis, kan det overvejes at øge dosis med 200 mg/dag hver 7. til 28. dag, hvis frit kortisol i urinen og/eller plasma-kortisolniveauet ligger over normalområdet.
English: The list above is not an inclusive list of compounds that may interact with ketoconazole and result in potentially life-threatening reactions.
Danish: Ovenstående liste over stoffer, der kan interagere med ketoconazol og medføre potentielt livstruende reaktioner, er ikke udtømmende.
English: Reboxetine
Danish: Reboxetin
English: AUC: ↑ 5.5-fold
Danish: AUC: ↑ 5,5 gange
English: microcrystalline cellulose, silica colloidal, magnesium stearate
Danish: 2), povidon, mikrokrystallinsk cellulose, kolloidt silica, magnesiumstearat
English: Monitor and instruct patients on the signs and symptoms associated with hypocortisolism (e.g. weakness, fatigue, anorexia, nausea, vomiting, hypotension, hyperkalemia, hyponatraemia, hyperkalaemia or hypoglycaemia).
Danish: Patienterne skal monitoreres og informeres om de tegn og symptomer, der er associeret med hypokortisolisme (f.eks. svaghed, træthed, anoreksi, kvalme, opkastning, hypotension, hyperkaliæmi, hyponatriæmi eller hypoglykæmi).
English: Potential ↑in plasma concentrations of carbamazepine and phenytoin
Danish: Potentiel ↑ i plasmakoncentrationen af carbamazepin og phenytoin.
English: Cmax: ↓0.56-fold
Danish: Cmax: ↓ 0,56 gange Nevirapin:
English: (See also “Effects of other medicinal products on the metabolism of Ketoconazole HRA ”).
Danish: (se også ”Virkninger af andre lægemidler på Ketoconazole HRAs metabolisme”).
English: Dose adjustment of these medicinal products may be required.
Danish: Dosisjustering af disse lægemidler kan være nødvendig.
English: Pregnancy, breast-feeding and fertility
Danish: Graviditet, amning and frugtbarhed
English: In case of adrenal insufficiency, Ketoconazole HRA treatment should be temporarily discontinued or the dose reduced and, if needed, a corticosteroid substitution therapy added.
Danish: Ved binyrebarkinsufficiens bør Ketoconazole HRA-behandling seponeres midlertidig eller dosis reduceres, og substitutionsbehandling med kortikosteroid bør tilføjes, hvis det er nødvendigt.
English: Dose adjustement of buspirone may be required.
Danish: Justering af buspirondosis kan være nødvendig.
English: Co-administration of ketoconazole and pasireotide is not recommended since the combination can lead to a QT prolongation in patients with known cardiac rhythm disorders.
Danish: Ketoconazol bør ikke anvendes sammen med pasireotid, eftersom denne kombination kan medføre QTforlængelse hos patienter med kendt uregelmæssig hjerterytme.
English: Not recommended due to an increased risk of QT prolongation.
Danish: Bør ikke anvendes pga. øget risiko for QT-forlængelse.
English: • Skin reactions (urticaria)
Danish: • Hudreaktioner (nældefeber)
English: You should stop your treatment and contact your doctor immediately if you feel unwell or experience symptoms such as lack of appetite, nausea, vomiting, fatigue, jaundice, abdominal pain or dark urine.
Danish: Du skal stoppe behandlingen og straks kontakte lægen, hvis du bliver utilpas eller oplever symptomer såsom appetitløshed, kvalme, opkastning, træthed, gulsot, mavesmerter eller mørk urin.
English: ↑in plasma concentrations of oxycodone have been observed
Danish: ↑ i plasmakoncentrationen af oxycodon er observeret.
English: The degrees of interaction mentioned below are not absolute values and may be dependent on the ketoconazole dose given, i.e. many results are reported following a ketoconazole dose of 200 mg and a stronger interaction may be expected at a higher dose and/or shorter dosing interval.
Danish: Der er rapporteret mange resultater efter en ketoconazoldosis på 200 mg, og der kan forventes en kraftigere interaktion ved en højere dosis og/eller et kortere doseringsinterval.
English: Due to the risk of serious hepatic toxicity, close follow-up of patients is required (see section 4.2).
Danish: Tæt opfølgning af patienterne er påkrævet på grund af risiko for alvorlig hepatotoksicitet (se pkt.
English: How to take Ketoconazole HRA 4.
Danish: Sådan skal du tage Ketoconazole HRA 4.
English: Contraindicated due to the increased risk of serious cardiovascular events including QT prolongation and torsade de pointes, or respiratory or CNS depression (see section 4.3).
Danish: Kontraindiceret pga. øget risiko for alvorlige kardiovaskulære bivirkninger, herunder QTforlængelse og torsades de pointes, samt respirations- og CNSdepression (se pkt.
English: Dose adjustment of cinacalcet may be required.
Danish: Justering af cinacalcetdosis kan være nødvendig.
English: Ketoconazole is an imidazole derivative that is a potent inhibitor of cortisol synthesis resulting from its ability to inhibit several cytochrome P450 enzymes in the adrenal glands.
Danish: Ketoconazol er et imidazolderivat og en potent hæmmer af kortisolsyntesen på grund af dets evne til at hæmme flere CYP-enzymer i binyrerne.
English: Ketoconazole HRA 200 mg tablets ketoconazole
Danish: Ketoconazole HRA 200 mg tabletter ketoconazol
English: Urological Drugs Fesoterodine Tolterodine Solifenacin
Danish: Urologiske lægemidler Fesoterodin Tolterodin
English: cilostazol, warfarin and others coumarin like - HIV medicines such as maraviroc, indinavir, nevirapine, ritonavir - certain medicines used for cancer such as vinca alkaloids, busulfan, docetaxel, erlotinib, imatinib, dasatinib,
Danish: edoxaban, cilostazol samt warfarin og andre coumarin-lignende lægemidler - lægemidler mod HIV såsom maraviroc, indinavir, nevirapin, ritonavir - visse lægemidler mod kræft såsom vinka-alkaloider (vincristin, vinblastin), busulfan, docetaxel, erlotinib,
English: ↑in plasma concentrations of praziquantel have been observed
Danish: ↑ i plasmakoncentrationen af praziquantel er observeret.
English: During the treatment: - close clinical follow-up should be undertaken - measurement of liver enzymes (ASAT, ALAT, gamma GT and alkaline phosphatase) and bilirubin, should be performed at frequent intervals:
Danish: Før behandlingen startes, er følgende obligatorisk: - Måling af leverenzymer (ASAT, ALAT, gamma-GT og alkalisk fosfatase) og bilirubin.
English: Ketoconazole HRA contains lactose
Danish: Ketoconazole HRA indeholder lactose
English: AUC: ↑ 2 fold Cmax: ↑ 2 fold
Danish: AUC: ↑ 2 gange Cmax: ↑ 2 gange
English: Cardiovascular Drugs, Miscellaneous Ranolazine
Danish: Diverse kardiovaskulære lægemidler Ranolazin
English: Co-administration of ketoconazole and pasireotide is not recommended since the combination can lead to QT prolongation in patients with known cardiac rhythm disorders (see section 4.5).
Danish: Ketoconazol bør ikke administreres sammen med pasireotid, eftersom denne kombination kan medføre QTforlængelse hos patienter med kendt uregelmæssig hjerterytme (se pkt.
English: Analgesic opioid Methadone
Danish: Opioidanalgetika Methadon
English: A dose reduction of ketoconazole should be considered when coadministered with ritonavir dosed as an antiretroviral medicinal product or as a pharmacokinetic enhancer.
Danish: Nedsættelse af ketoconazoldosis bør overvejes, når det administreres sammen med ritonavir, doseret enten som antiretroviralt middel eller som farmakokinetisk forstærker (se også ”Virkninger af andre lægemidler på Ketoconazole HRAs metabolisme”).
English: AUC: ↑2.1-fold Cmax: ↑1.1-fold t1/2: ↑ 4-fold
Danish: AUC: ↑2,1 gange Cmax: ↑1,1 gange t1/2: ↑ 4 gange
English: Ketoconazole can be reintroduced thereafter at a lower dose (see section 4.4); - Treatment with ketoconazole can be stopped abruptly without a need for progressive dose decrease where a change in the therapeutic strategy (e.g. surgery) is desired.
Danish: - Ketoconazol kan seponeres pludseligt uden en progressiv dosisnedsættelse, når det ønskes at ændre behandlingsstrategi (f.eks. operation).
English: Diuretics Eplerenone
Danish: Diuretika Eplerenon
English: Contraindicated due to an increase in the plasma concentrations (see section 4.3).
Danish: Kontraindiceret pga. øget plasmakoncentration (se pkt.
English: ↑in plasma concentrations of nadolol have been observed
Danish: ↑ i plasmakoncentrationen af nadolol er observeret.
English: Contraindicated in patients with severe renal impairment due to the risk of QT interval prolongation and serious hepatic adverse reactions (see section 4.3).
Danish: Kontraindiceret hos patienter med svært nedsat nyrefunktion på grund af risikoen for forlænget QT-interval og alvorlige leverbivirkninger (se pkt.
English: • Diarrhoea • Skin reactions (pruritus, rash)
Danish: • Diarré • Hudreaktioner (kløe, udslæt)
English: If you forget to take Ketoconazole HRA
Danish: Hvis du har glemt at tage Ketoconazole HRA
English: If you stop taking Ketoconazole HRA
Danish: Hvis du holder op med at tage Ketoconazole HRA
English: Dose adjustment of aliskiren may be required.
Danish: Justering af aliskirendosis kan være nødvendig.
English: Warning regarding excipients
Danish: Advarsel vedrørende hjælpestoffer
English: Ombitasvir: AUC: ↑1.3-fold
Danish: Ombitasvir: AUC: ↑1,3 gange
English: Rest of drugs ↑in plasma concentrations of these drugs have been observed
Danish: Øvrige lægemidler: ↑ i plasmakoncentrationen af disse lægemidler er observeret.
English: Potencial ↓ in plasma concentrations of ketoconazole are expected.
Danish: Potentiel ↓ i plasmakoncentrationen af ketoconazol forventes.
English: Your adrenal function will be monitored at regular intervals as this is the standard care in the follow-up of Cushing's syndrome therapy and since adrenal insuficiency can occur during the treatment.
Danish: Dette er standard i forbindelse med opfølgning af behandlingen af Cushings syndrom, og fordi nedsat binyrefunktion kan forekomme under behandlingen.
English: Other medicinal products and Ketoconazole HRA
Danish: Brug af anden medicin sammen med Ketoconazole HRA
English: Not recommended due to the increased risk of adverse reactions.
Danish: Bør ikke anvendes på grund af øget risiko for bivirkninger.
English: Contraindicated due to the risk of QT prolongation (see section 4.3).
Danish: Kontraindiceret pga. risiko for QTforlængelse (se pkt.
English: Asthenia
Danish: Leversygdom
English: Lipid Lowering Drugs Lovastatin, simvastatin, atorvastatin*
Danish: Statiner Lovastatin Simvastatin Atorvastatin*
English: ↑in plasma concentrations of colchicine have been observed
Danish: ↑ i plasmakoncentrationen af colchicin er observeret.
English: Dose adjustement of repaglinide may be required.
Danish: Justering af repagliniddosis kan være nødvendig.
English: Telithromycine:
Danish: Telithromycin:
English: Not recommended due to the potential for hepatic toxicity (see section 4.3).
Danish: Bør ikke anvendes pga. risiko for hepatotoksicitet (se pkt.
English: Contraindicated due to an increased risk of skeletal muscle toxicity, including rhabdomyolysis (see section 4.3).
Danish: Kontraindiceret pga. øget risiko for skeletmuskulaturtoksicitet, herunder rabdomyolyse (se pkt.
English: (Relative to Indinavir 800 mg TID alone)
Danish: Cmin: ↑ 1,3 gange (i forhold til indinavir 800 mg 3 gange dagligt alene).
English: Dasatinib ↑in plasma concentrations of Dasatinib have been observed Dabrafenib
Danish: Dasatinib: ↑ i plasmakoncentrationen af dasatinib er observeret.
English: Contraindicated due to an increased bleeding risk (see section 4.3).
Danish: Kontraindiceret pga. øget blødningsrisiko (se pkt.
English: Potential ↑in plasma concentrations of haloperidol.
Danish: Potentiel ↑ i plasmakoncentrationen af haloperidol.
English: Tolbutamide
Danish: Tolbutamid
English: AUC: ↑ 2.2 fold
Danish: AUC: ↑ 2,2 gange
English: ergotamine and methylergometrine (methylergonovine) - certain medicines used in cancers: irinotecan, everolimus - sirolimus: used to prevent your body from rejecting a kidney transplant - tolvaptan used for a specific disease called “syndrome of inappropriate antidiuretic hormone secretion” - vardenafil in men older than 75 years - medicine to treat erectile dysfunction in adults men - certain medicines for HIV: saquinavir/ritonavir, saquinavir - certain medicines to treat long-term (chronic) hepatitis C (an infectious disease that affects the liver, caused by the hepatitis C virus): Paritaprevir/Ombitasvir (ritonavir) - methadone: medicine to treat dependence to drugs - In patients with renal disorders:
Danish: - visse lægemidler, der anvendes til svære psykiske lidelser og svær depression: pimozid, sertindol, lurasidon, quetiapin - visse lægemidler, der anvendes til allergi: mizolastin - dabigatran, der anvendes til at forebygge blodpropper - visse lægemidler, der anvendes som hjælp til at falde i søvn og til at dulme angst: triazolam, alprazolam, midazolam (taget gennem munden) - visse lægemidler, der anvendes mod migræneanfald: dihydroergotamin, ergometrin, ergotamin og methylergometrin - visse lægemidler, der anvendes mod kræft: irinotecan, everolimus - sirolimus, der anvendes til at forhindre kroppen i at afstøde en transplanteret nyre - tolvaptan, der anvendes til en speciel sygdom med uhensigtsmæssig produktion af antidiuretisk hormon (SIADH) - vardenafil hos mænd over 75 år - lægemiddel til behandling af rejsningsbesvær hos voksne mænd - visse lægemidler mod HIV: saquinavir/ritonavir, saquinavir - visse lægemidler mod langvarig (kronisk) hepatitis C (smitsom leverbetændelse, som skyldes hepatitis C-virus): Paritaprevir/Ombitasvir (ritonavir) - methadon: lægemiddel til behandling af stofafhængighed - Hos patienter med nyresygdomme: colchicin, der anvendes til behandling af podagra fesoterodin og solifenacin, der anvendes til behandling af symptomerne på en overaktiv blære telithromycin og clarithromycin, der anvendes til behandling af infektioner
English: • Tongue discoloration
Danish: • Misfarvning af tungen
English: Dose adjustment of praziquantel may be required.
Danish: Justering af praziquanteldosis kan være nødvendig.
English: Eplerenone:
Danish: Eplerenon:
English: cannot be estimated from the available data.
Danish: De foreliggende data er beskrevet i pkt.
English: o weekly for one month after initiation of the treatment o then monthly for 6 months o weekly during one month whenever the dose was increased.
Danish: o ugentligt i én måned efter hver dosisøgning.
English: Contraindicated due to an increase risk of edema and congestive heart failure (see section 4.3).
Danish: Kontraindiceret pga. øget risiko for ødem og hjerteinsufficiens (se pkt.
English: AUC: ↑ 24-fold Cmax: ↑ 29-fold
Danish: AUC: ↑ 24 gange Cmax: ↑ 29 gange
English: AUC: ↑ 1.8-fold
Danish: AUC: ↑ 1,8 gange
English: AUC: ↑ 10.9-fold Cmax: ↑ 4.4-fold
Danish: AUC: ↑ 10,9 gange Cmax: ↑ 4,4 gange
English: Hepatic impairment Ketoconazole is contraindicated in patients with acute or chronic hepatic impairment (see sections 4.3, 4.4 and
Danish: Ketoconazol må ikke anvendes til patienter med akut eller kronisk nedsat leverfunktion (se pkt.
English: - Ketoconazole is a potent inhibitor of CYP3A4 and can inhibit the metabolism of medicinal products metabolised by this enzyme.
Danish: Virkninger af ketoconazol på andre lægemidlers metabolisme - Ketoconazol er en potent CYP3A4-hæmmer og kan hæmme metaboliseringen af lægemidler, der metaboliseres af dette enzym.
English: AUC: ↑ 1.4-fold Cmax: ↔
Danish: AUC: ↑ 1,4 gange Cmax: ↔
English: Potential ↑in plasma concentrations of digoxine
Danish: Potentiel ↑ i plasmakoncentrationen af digoxin.
English: Potential ↑in plasma concentrations of clarithromycin
Danish: Potentiel ↑ i plasmakoncentrationen af clarithromycin.
English: Potential ↑in plasma concentrations of disopyramide and quinidine
Danish: Potentil ↑ i plasmakoncentrationen af disopyramid og quinidin.
English: Very rare side effects (may affect up to 1 in 10,000 people):
Danish: Meget almindelige bivirkninger (kan forekomme hos flere end 1 ud af 10 personer):
English: (CYP3A4 enzyme induction)
Danish: (CYP3A4-enzyminduktion)
English: oxycodone - certain medicines used for nausea and vomiting: domperidone, aprepitant - naloxegol (medicine for treatment of constipation specifically caused by strong pain medicines) - solifenacin, fesoterodine in patients with renal impairment - others: sildenafil, , tolterodine, mitotane, praziquantel, eletriptan, , salmeterol, bosentan, midazolam (by injection), tadalafil, vardenafil, temsirolimus, cinalcacet, tacrolimus, ebastine, ciclosporine, colchicine
Danish: risperidon - visse typer hjertemedicin: verapamil, digoxin, nadolol, aliskiren - visse krampestillende lægemidler: carbamazepin, phenytoin - visse glukokortikoider såsom budesonid, fluticason, dexamethason, methylprednisolon, ciclesonid - visse stærke smertestillende lægemidler (narkotika) såsom alfentanyl, fentanyl, buprenorphin (injektion og under tungen), oxycodon - visse lægemidler, der anvendes mod kvalme og opkastning: domperidon, aprepitant - naloxegol (middel til behandling af forstoppelse, som specifikt skyldes stærk smertestillende medicin) - solifenacin, fesoterodin hos patienter med nedsat nyrefunktion - øvrige: sildenafil, tolterodin, mitotan, praziquantel, eletriptan, salmeterol, bosentan, midazolam (som injektion), tadalafil, vardenafil, temsirolimus, cinacalcet, tacrolimus, ebastin, ciclosporin, colchicin
English: Potential ↑in plasma concentrations of sertindole.
Danish: Potentiel ↑ i plasmakoncentrationen af sertindol.
English: (CYP3A enzyme inhibition)
Danish: (CYP3A-enzyminduktion)
English: Contraindicated due to the increased risk of adverse reactions (see section
Danish: Kontraindiceret på grund af den øgede risiko for bivirkninger (se pkt.
English: Contraindicated due to the risk of serious cardiovascular events including QT prolongation (see section 4.3).
Danish: Kontraindiceret pga. risiko for alvorlige kardiovaskulære bivirkninger, herunder QTforlængelse (se pkt.
English: In the case of signs suggestive of an adrenal insufficiency, in addition to the general measures to eliminate the medicinal product and reduce its absorption, a 100 mg dose of hydrocortisone should be administered at once, together with saline and glucose infusions.
Danish: Ved tegn på binyrebarkinsufficiens bør der straks administreres 100 mg hydrocortison sammen med infusion af natriumchlorid og glucose ud over de generelle forholdsregler for at eliminere lægemidlet og reducere absorptionen af det. Tæt overvågning vil være nødvendig: Blodtryk samt væske- og elektrolytbalance skal monitoreres i et par dage.
English: Potential ↑ in plasma concentrations of rifabutine.
Danish: Potentiel ↑ i plasmakoncentrationen af rifabutin.
English: ↑in plasma concentrations of tolterodine have been observed
Danish: ↑ i plasmakoncentrationen af tolterodin er observeret.
English: Other Tolvaptan
Danish: Andre Tolvaptan
English: Potential ↑in plasma concentrations of pimozide.
Danish: Potentiel ↑ i plasmakoncentrationen af pimozid.
English: This leaflet was last revised in. Other sources of information
Danish: Denne indlægsseddel blev senest ændret
English: Potential ↑in plasma concentrations of warfarin
Danish: Potentiel ↑ i plasmakoncentrationen af warfarin.
English: Potential ↑in plasma concentrations of these drugs
Danish: Potentiel ↑ i plasmakoncentrationen af disse lægemidler.
English: Potential ↑in plasma concentrations of buspirone.
Danish: Potentiel ↑ i plasmakoncentrationen af buspiron.
English: Ketoconazole has a moderate influence in the ability to drive and use machines Patients should be warned about the potential for dizziness and somnolence (see section 4.8) and should be advised not to drive or operate machines if any of these symptoms occur.
Danish: 4.8) og bør frarådes at føre motorkøretøj eller betjene maskiner, hvis nogen af disse symptomer forekommer.
English: Aripiprazole
Danish: Aripiprazol
English: Dose adjustment of paclitaxel may be required.
Danish: Justering af paclitaxeldosis kan være nødvendig.
English: Potential ↑ in plasma concentrations of methadone
Danish: Potentiel ↑ i plasmakoncentrationen af methadon.
English: Tolbutamide: AUC: ↑ 1.7-fold
Danish: Tolbutamid: AUC: ↑ 1,7 gange
English: AUC: ↑ 3.0 to 3.9-fold
Danish: Ranolazin: AUC: ↑ 3,0-3,9 gange
English: AUC: ↑ 2-fold
Danish: AUC: ↑ 2 gange
English: - certain medicines used for the treatment of the paludism: quinidine, halofantrine - certain medicines used for severe mental health disorders and severe depression: pimozide,
Danish: - visse lægemidler, der anvendes til behandling af malaria: quinidin, halofantrin
English: - This medicine does not require any special storage conditions - Do not throw away any medicines via wastewater or household waste.
Danish: Af hensyn til miljøet må du ikke smide medicinrester i afløbet, toilettet eller skraldespanden.
English: AUC: ↑ 3.0 fold Cmax: ↑ 3.0 fold
Danish: AUC: ↑ 3,0 gange Cmax: ↑ 3,0 gange
English: Oedema peripheral, malaise, hot flush
Danish: Perifert ødem, utilpashed, hedestigninger
English: AUC: ↑ 5.9-fold Cmax: ↑ 2.7-fold
Danish: AUC: ↑ 5,9 gange Cmax: ↑ 2,7 gange
English: Potential ↑in plasma concentrations of sildenafil
Danish: Potentiel ↑ i plasmakoncentrationen af sildenafil.
English: AUC: ↑ 1.3-fold
Danish: AUC: ↑ 1,3 gange
English: Before starting the treatment, it is mandatory: - to measure liver enzymes (ASAT, ALAT, gammaGT and alkaline phosphatase) and bilirubin - to inform the patients about the risk of hepatotoxicity, including to stop the treatment and to contact their doctor immediately if they feel unwell or in the event of symptoms such as anorexia, nausea, vomiting, fatigue, jaundice, abdominal pain or dark urine.
Danish: - Patienterne skal informeres om risikoen for hepatotoksicitet, herunder at de skal seponere behandlingen og straks kontakte deres læge, hvis de føler utilpashed eller får symptomer som anoreksi, kvalme, opkastning, træthed, gulsot, abdominalsmerter eller mørk urin.
English: AUC: ↑ 2.3-fold Cmax: ↑ 2.0-fold
Danish: AUC: ↑ 2,3 gange Cmax: ↑ 2,0 gange
English: Buprenorphine IV and sublingual
Danish: og sublingual
English: AUC: ↑ 6.2-fold Cmax: ↑ 3.4-fold
Danish: AUC: ↑ 6,2 gange Cmax: ↑ 3,4 gange
English: AUC: ↑ 1.9-fold Cmax: ↑ 1.7-fold
Danish: AUC: ↑ 1,9 gange Cmax: ↑ 1,7 gange
English: Dose adjustment of tolbutamide may be required.
Danish: Justering af tolbutamiddosis kan være nødvendig.
English: Dose adjustment of risperidone may be required.
Danish: Justering af risperidondosis kan være nødvendig.
English: ↑in plasma concentrations of tolvaptan have been observed
Danish: ↑ i plasmakoncentrationen af tolvaptan er observeret.
English: AUC: ↑ 2.6-fold Cmax: ↑2.5-fold
Danish: AUC: ↑ 2,6 gange Cmax: ↑ 2,5 gange
English: AUC: ↑ 2.6-fold Cmax: ↑1.7-fold
Danish: AUC: ↑ 2,6 gange Cmax: ↑ 1,7 gange
English: • Gynaecomastia (enlargement in breast tissues in male)
Danish: • Gynækomasti (forstørrelse af brystvævet hos mænd)