FrancophonIA/ELRC3.0 huggingface dataset:
English: It is recommended that paediatric patients, if possible, be brought up to date with all immunisations in agreement with current immunisation guidelines prior to initiating adalimumab therapy.
Croatian: Preporučuje se da se pedijatrijske bolesnike, ako je moguće, cijepi u skladu sa svim važećim smjernicama za cijepljenje prije započinjanja liječenja adalimumabom.
English: • Certain vaccines contain living but weakened forms of disease-causing bacteria or viruses and should not be given during treatment with Kromeya in case they cause infections.
Croatian: • Određena cjepiva sadrže živuće ali oslabljene oblike bakterija ili virusa koji uzrokuju bolest pa se ne smiju primiti za vrijeme liječena lijekom Kromeya jer mogu uzrokovati infekcije.
English: • reactivation of hepatitis B infection;
Croatian: • reaktivacija hepatitis B infekcije,
English: Alcohol pads
Croatian: Jastučići s alkoholom
English: A single pre-filled syringe or pre-filled pen may be stored at temperatures up to a maximum of 25°C for a period of up to 14 days.
Croatian: Jedna napunjena štrcaljka ili napunjena brizgalica može se čuvati na temperaturama do maksimalno 25°C u trajanju do 14 dana.
English: • Push and hold the pre-filled pen firmly against your skin until the safety guard is fully depressed.
Croatian: • Napunjenu brizgalicu pritisnite na Vašu kožu i držite tako čvrsto pritisnutom sve dok sigurnosni štitnik nije u potpunosti pritisnut.
English: After Injection
Croatian: Nakon injektiranja
English: Blood and lymphatic system disorders*
Croatian: Poremećaj krvi i limfnog sustava*
English: • angioedema (localized swelling of the skin);
Croatian: • angioedem (lokalizirano oticanje kože),
English: A modified Total Sharp Score (mTSS), which included distal interphalangeal joints (i.e., not identical to the TSS used for rheumatoid arthritis), was used.
Croatian: Korišten je modificirani TSS (mTSS), koji je uključivao i distalne interfalangealne zglobove (tj. nije jednak TSS-u korištenom u ispitivanjima kod reumatoidnog artritisa).
English: Always use this medicine exactly as your child's doctor or pharmacist has instructed.
Croatian: Uvijek primijenite ovaj lijek točno onako kako Vam je rekao liječnik Vašeg djeteta ili ljekarnik.
English: The vial must be protected from light, and discarded if not used within the 14-day period.
Croatian: Bočicu se mora zaštiti od svjetlosti i zbrinuti ako se ne iskoristi unutar 14 dana.
English: The active ingredient in Kromeya, adalimumab, is a monoclonal antibody.
Croatian: Djelatna tvar u lijeku Kromeya, adalimumab, je monoklonsko protutijelo.
English: 3.1 Check the transparent syringe housing to make sure that:
Croatian: 3.1 Provjerite prozirno kućište štrcaljke kako biste bili sigurni u sljedeće:
English: No data are available on the secondary transmission of infection by live vaccines in patients receiving adalimumab.
Croatian: Nema dostupnih podataka o sekundarnom prijenosu infekcije živim cjepivima u bolesnika liječenih adalimumabom.
English: 4.4 Pull back the pink needle safety cover toward the syringe.
Croatian: 4.4 Povucite ružičasti sigurnosni pokrov za iglu unatrag prema štrcaljki
English: ACR 20 Week 52 62.6% 54.4% 72.8% Week 104 56.0% 49.3% 69.4% ACR 50 Week 52 45.9% 41.2% 61.6% < 0.001 < 0.001 0.317 Week 104 42.8% 36.9% 59.0% < 0.001 < 0.001 0.162 ACR 70 Week 52 27.2% 25.9% 45.5% < 0.001 < 0.001 0.656 Week 104 28.4% 28.1% 46.6% < 0.001 < 0.001 0.864 a. p-value is from the pairwise comparison of methotrexate monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test. b. p-value is from the pairwise comparison of adalimumab monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test c. p-value is from the pairwise comparison of adalimumab monotherapy and methotrexate monotherapy using the Mann-Whitney U test
Croatian: ACR 20 52 tjedna 62,6% 54,4% 72,8% 0,013 104 tjedna 56,0% 49,3% 69,4% 0,002 ACR 50 52 tjedna 45,9% 41,2% 61,6% < 0,001 104 tjedna 42,8% 36,9% 59,0% < 0,001 ACR 70 52 tjedna 27,2% 25,9% 45,5% < 0,001 104 tjedna 28,4% 28,1% 46,6% < 0,001 p-vrijednost dobivena sparenom usporedbom monoterapije metotreksatom i kombinirane terapije adalimumabom i metotreksatom uz primjenu Mann-Whitney U testa p-vrijednost dobivena sparenom usporedbom monoterapije adalimumabom i kombinirane terapije adalimumabom i metotreksatom uz primjenu Mann-Whitney U testa p-vrijednost dobivena sparenom usporedbom monoterapije adalimumabom i monoterapije metotreksatom uz primjenu Mann-Whitney U test
English: For single use only
Croatian: Samo za jednokratnu primjenu.
English: Kromeya in combination with methotrexate, is indicated for:
Croatian: U kombinaciji s metotreksatom, Kromeya je indicirana za:
English: Ped ACR 30 response (n/N)
Croatian: ACR 30 (n/N)
English: Do not shake the syringe.
Croatian: Nemojte tresti štrcaljku.
English: Psoriasis study II (CHAMPION) compared the efficacy and safety of adalimumab versus methotrexate and placebo in 271 patients.
Croatian: U ispitivanju Psoriasis Study II (CHAMPION) uspoređivale su se djelotvornost i sigurnost adalimumaba u odnosu na metotreksat i placebo u 271 bolesnika.
English: 3.1 Check the syringe to make sure that: • The syringe, the clear needle guard, and the needle cap are not cracked or damaged (Figure G).
Croatian: 3.1 Provjerite štrcaljku kako biste bili sigurni u sljedeće: ⚫ štrcaljka, prozirni štitnik igle i poklopac igle nisu napukli ili oštećeni (slika G).
English: Coagulation and bleeding disorders (including activated partial thromboplastin time prolonged), autoantibody test positive (including double stranded DNA antibody), blood lactate dehydrogenase increased
Croatian: često poremećaji koagulacije i krvarenja (uključujući produljenje aktiviranog parcijalnog tromboplastinskog vremena), pozitivan nalaz testa na autoprotutijela (uključujući protutijela na dvolančanu DNK), povišena laktat dehidrogenaza u krvi
English: Active tuberculosis or other severe infections such as sepsis, and opportunistic infections (see section
Croatian: Aktivna tuberkuloza ili druge teške infekcije, poput sepse, i oportunističke infekcije (vidjeti dio 4.4).
English: Of those patients who had a response at week 8, 47% were in response, 29% were in remission, 41% had mucosal healing, and 20% were in steroid-free remission for ≥ 90 days at week 52.
Croatian: Od bolesnika koji su imali odgovor u 8. tjednu, 47% ih je postiglo klinički odgovor, 29% ih je bilo u remisiji, a 41% je imalo zacjeljivanje sluznice, dok ih je u 52. tjednu 20% bilo u remisiji bez primjene steroida ≥ 90 dana.
English: • The name on the syringe says Kromeya (Figure K).
Croatian: • ime na štrcaljki glasi Kromeya (slika K).
English: In patients who have been exposed to tuberculosis and patients who have travelled in areas of high risk of tuberculosis or endemic mycoses, such as histoplasmosis, coccidioidomycosis, or blastomycosis, the risk and benefits of treatment with Kromeya should be considered prior to initiating therapy (see Other opportunistic infections).
Croatian: U bolesnika koji su bili izloženi tuberkulozi ili bolesnika koji su putovali u područja visokog rizika od tuberkuloze ili endemskih mikoza, kao što su histoplazmoza, kokcidioidomikoza ili blastomikoza, prije započinjanja liječenja treba razmotriti rizike i prednosti liječenja lijekom Kromeya (vidjeti Druge oportunističke infekcije).
English: No clinical data are available on the use of an adalimumab loading dose in children < 6 years of age (see section 5.2).
Croatian: Nisu dostupni klinički podaci o primjeni udarne doze adalimumaba u djece u dobi od < 6 godina (vidjeti dio 5.2).
English: It is recommended that, if possible, children be given all the scheduled vaccinations for their age before they start treatment with Kromeya.
Croatian: Ako je moguće, preporučuje se da djeca prime sva predviđena cjepiva za njihovu dob prije započinjanja terapije lijekom Kromeya.
English: Administration of live vaccines (e.g., BCG vaccine) to infants exposed to adalimumab in utero is not recommended for 5 months following the mother's last adalimumab injection during pregnancy.
Croatian: Djeci koja su u maternici bila izložena adalimumabu ne preporučuje se davati živa cjepiva (npr. cjepivo BCG) najmanje 5 mjeseci otkad je majka u trudnoći primila zadnju injekciju adalimumaba.
English: • facial oedema (swelling) associated with allergic reactions;
Croatian: • edem (oteklina) lica povezana s alergijskim reakcijama,
English: Disease flares at the end of 32 weeks a
Croatian: Egzacerbacija bolesti pri kraju razdoblja od 32 tjedna a
English: The Kromeya pre-filled pen contains a pre-filled syringe with Kromeya.
Croatian: Kromeya napunjena brizgalica sadrži napunjenu štrcaljku s lijekom Kromeya.
English: Study UV I evaluated 217 patients with active uveitis despite treatment with corticosteroids (oral prednisone at a dose of 10 to 60 mg/day).
Croatian: Ispitivanje UV I ocjenjivalo je 217 bolesnika s aktivnim uveitisom unatoč liječenju kortikosteroidima (oralni prednizon u dozi od 10 do 60 mg/dan).
English: In study UV I statistically significant differences in favour of adalimumab versus placebo were observed for each component of treatment failure.
Croatian: U ispitivanju UV I primijećene su statistički značajne razlike u korist adalimumaba naspram placeba za svaku komponentu neuspjeha liječenja.
English: • shortness of breath with exertion or upon lying down or swelling of the feet.
Croatian: • nedostatak zraka u naporu ili nakon lijeganja, oticanje stopala.
English: • Tell your doctor if your child is a carrier of the hepatitis B virus (HBV), if he/she has active HBV infection or if you think he/she might be at risk of contracting HBV.
Croatian: • Recite liječniku ako je Vaše dijete nositelj virusa hepatitisa B (HBV), ako ima aktivnu HBV infekciju ili mislite da je u riziku od zaraze HBV-om.
English: Women of childbearing potential should consider the use of adequate contraception to prevent pregnancy and continue its use for at least five months after the last Kromeya treatment.
Croatian: Žene reproduktivne dobi trebaju razmotriti korištenje odgovarajuće kontracepcije kako bi spriječile trudnoću i trebale bi je nastaviti koristiti još najmanje pet mjeseci nakon posljednje doze lijeka Kromeya.
English: In RA studies I-IV, all individual components of the ACR response criteria (number of tender and swollen joints, physician and patient assessment of disease activity and pain, disability index (HAQ) scores and CRP (mg/dl) values) improved at 24 or 26 weeks compared to placebo.
Croatian: U ispitivanjima RA I - IV sve pojedinačne komponente kriterija ACR odgovora (broj bolnih i otečenih zglobova, liječnikova i bolesnikova ocjena aktivnosti bolesti i boli, indeks onesposobljenosti (HAQ) i razine CRP-a (mg/dl)) pokazale su poboljšanje nakon 24 ili 26 tjedana primjene adalimumaba u odnosu na placebo.
English: Corticosteroid taper was permitted after week
Croatian: Postupno smanjenje doze kortikosteroida bilo je dopušteno nakon 8 tjedana.
English: 2.1 Wash your hands with soap, water and dry them well.
Croatian: 2.1 Operite ruke sapunom i vodom i dobro ih osušite.
English: • symptoms of nerve root compression (including low back pain and leg pain);
Croatian: • simptome kompresije korijena živca (uključujući bolove u donjem dijelu leđa i nozi),
English: Kromeya works by reducing this inflammation.
Croatian: Kromeya djeluje tako da smanjuje tu upalu.
English: Cases of worsening congestive heart failure have also been reported in patients receiving adalimumab.
Croatian: Slučajevi pogoršanja kongestivnog zatajenja srca također su prijavljeni i u bolesnika liječenih adalimumabom.
English: Side effects may occur up to 4 months or more after the last Kromeya injection.
Croatian: Nuspojave se mogu javiti još 4 mjeseca ili dulje nakon ubrizgavanja zadnje doze lijeka Kromeya.
English: The benefits and risks of continued 40 mg weekly or 80 mg every other week therapy should be carefully reconsidered in a patient with an inadequate response after the increase in dosage (see section 5.1).
Croatian: Potrebno je vrlo pažljivo procijeniti koristi i rizike kontinuiranog liječenja lijekom u dozi od 40 mg jednom tjedno ili 80 mg svaki drugi tjedan u bolesnika u kojih nije postignut zadovoljavajući odgovor nakon povećanja doziranja (vidjeti dio 5.1).
English: Refer to package leaflet for alternative storage details.
Croatian: Pogledajte uputu o lijeku za detalje o alternativnim mjerama čuvanja.
English: Kromeya 40 mg/0.8 mL solution for injection for paediatric use may be stored at temperatures up to a maximum of 25°C for a period of up to 14 days.
Croatian: Kromeya 40 mg/0,8 ml otopina za injekciju za pedijatrijsku uporabu može se čuvati na temperaturama do maksimalno 25°C u trajanju do 14 dana.
English: If you receive Kromeya while you are pregnant, your baby may be at higher risk for getting an infection for up to about five months after the last dose you received during pregnancy.
Croatian: Ako ste lijek Kromeya uzeli tijekom trudnoće, Vaše dijete može biti pod povećanim rizikom od dobivanja infekcije i do pet mjeseci nakon što ste primili posljednju dozu u trudnoći.
English: MTX = methotrexate **p < 0.01, adalimumab versus placebo
Croatian: MTX = metotreksat **p<0,01, adalimumab u usporedbi s placebom
English: • multiple sclerosis;
Croatian: • multipla skleroza,
English: c p = 0.031
Croatian: p < 0,01
English: If a patient develops symptoms suggestive of a lupus-like syndrome following treatment with Kromeya and is positive for antibodies against double-stranded DNA, further treatment with Kromeya should not be given (see section 4.8).
Croatian: Ako bolesnik nakon primjene lijeka Kromeya razvije simptome koji upućuju na sindrom nalik lupusu i pozitivan je na protutijela usmjerena protiv dvolančane DNK, terapija lijekom Kromeya ne smije se nastaviti (vidjeti dio 4.8).
English: Patients who achieved PASI 75 and PGA clear or minimal were withdrawn from treatment for up to 36 weeks and monitored for loss of disease control (i.e. a worsening of PGA by at least 2 grades).
Croatian: U bolesnika koji su postigli PASI 75 ili PGA rezultat 'bez bolesti' ili 'minimalno', liječenje je prekinuto tijekom razdoblja do najviše 36 tjedana te se pratio gubitak kontrole bolesti (tj. pogoršanje PGA rezultata za najmanje 2 stupnja).
English: Patients treated with Kromeya should be given the patient reminder card.
Croatian: Bolesnicima koji se liječe lijekom Kromeya treba dati posebnu Karticu s podsjetnikom za bolesnika.
English: • Merkel cell carcinoma (a type of skin cancer);
Croatian: • karcinom Merkelovih stanica (vrsta raka kože),
English: - if you have moderate or severe heart failure.
Croatian: • ako bolujete od umjerenog ili teškog zatajenja srca.
English: • sicca syndrome (including dry eyes and dry mouth);
Croatian: • sicca (suhi) sindrom (uključujući suhoću očiju i suhoću usta),
English: If your doctor considers that methotrexate is inappropriate, Kromeya can be given alone.
Croatian: Ako Vaš liječnik procijeni da je metotreksat neprikladan, Kromeya se može davati samostalno.
English: Choose a different injection site (at least 2.5 centimeters away from the previous injection site) each time to reduce redness, irritation or other skin problems.
Croatian: Svaki put odaberite drugo mjesto (barem 2,5 centimetra dalje od prethodnog mjesta injiciranja) kako biste smanjili crvenilo, nadraženost i druge probleme s kožom.
English: Kromeya should only be used during a pregnancy if needed.
Croatian: Kromeya se tijekom trudnoće smije primjenjivati samo ako je to neophodno.
English: A total of 233 PASI 75 responders at week 16 and week 33 received continuous adalimumab therapy for 52 weeks in Psoriasis study I, and continued adalimumab in the open-label extension trial.
Croatian: Ukupno su 233 bolesnika s odgovorom PASI 75 u 16. i 33. tjednu primala kontinuiranu terapiju adalimumabom kroz 52 tjedna u ispitivanju Psoriasis Study I te su nastavila s primanjem adalimumaba u otvorenom produžetku ispitivanja.
English: In a study of 64 patients with rheumatoid arthritis that were treated with adalimumab, there was no evidence of depression of delayed-type hypersensitivity, depression of immunoglobulin levels, or change in enumeration of effector T-, B,- NK-cells, monocyte/macrophages, and neutrophils.
Croatian: U ispitivanju 64 bolesnika s reumatoidnim artritisom liječena adalimumabom nije zabilježeno smanjenje odgođene preosjetljivosti, sniženje razina imunoglobulina niti promjene broja efektorskih T i B stanica, NK stanica, monocita/makrofaga i neutrofila.
English: Kromeya is recommended for use in combination with methotrexate.
Croatian: Preporučuje se da se Kromeya primjenjuje u kombinaciji s metotreksatom.
English: Thereafter, the usual dose is 20 mg every other week.
Croatian: Nakon toga, uobičajena doza je 20 mg svaki drugi tjedan.
English: 20 mg every other week in combination with methotrexate
Croatian: 20 mg svaki drugi tjedan u kombinaciji s metotreksatom
English: The number of all cause hospitalisations in the adalimumab treatment group was 0.18 per patient year vs. 0.26 per patient year in the placebo group and the corresponding figures for UC-related hospitalisations were 0.12 per patient year vs. 0.22 per patient year.
Croatian: Broj hospitalizacija zbog bilo kojeg uzroka u skupini liječenoj adalimumabom bio je 0,18 po bolesnik-godini u odnosu na 0,26 po bolesnik-godini u skupini koja je primala placebo, a odgovarajuće vrijednosti za hospitalizaciju povezanu s UC-om bile su 0,12 po bolesnik-godini u odnosu na 0,22 po bolesnik-godini.
English: • Place the pre-filled pen against your skin at a 90° angle (Figure N).
Croatian: • Postavite napunjenu brizgalicu na Vašu kožu pod kutom od 90° (slika N).
English: Kromeya can be taken together with methotrexate or certain disease-modifying anti-rheumatic agents (sulfasalazine, hydroxychloroquine, leflunomide and injectable gold preparations), corticosteroids or pain medications including non-steroidal anti-inflammatory drugs (NSAIDs).
Croatian: Kromeya se može primjenjivati istodobno s metotreksatom ili nekim antireumaticima koji mijenjaju tijek bolesti (sulfasalazinom, hidroksiklorokinom, leflunomidom i injekcijskim pripravcima zlata), kortikosteroidima ili lijekovima za ublažavanje boli, uključujući i nesteroidne protuupalne lijekove (NSAIL).
English: Patients who develop a new infection while undergoing treatment with Kromeya, should be monitored closely and undergo a complete diagnostic evaluation.
Croatian: Bolesnike u kojih se za vrijeme liječenja lijekom Kromeya razviju nove infekcije potrebno je pozorno pratiti i podvrgnuti kompletnoj dijagnostičkoj procjeni.
English: 1.5 Caution: Do not pick up the syringe by the plunger or the needle cap.
Croatian: 1.5 Oprez: Nemojte podizati štrcaljku držeći je za klip ili poklopac igle.
English: 4.1 Choose an injection site (Figure L) on:
Croatian: 4.1 Odaberite mjesto injiciranja (slika L) na:
English: • Always hold the syringe by the clear needle guard.
Croatian: • Uvijek držite štrcaljku za prozirni štitnik igle.
English: Kromeya can be given as monotherapy in case of intolerance to methotrexate or when continued treatment with methotrexate is inappropriate (for the efficacy in monotherapy see section 5.1).
Croatian: Kromeya se može davati kao monoterapija u slučajevima nepodnošenja metotreksata ili kada nastavak terapije metotreksatom nije prikladan (za djelotvornost monoterapije vidjeti dio 5.1).
English: Step 5 Clean the Injection Site
Croatian: 5. korak Očistite mjesto injiciranja
English: After 16 weeks of therapy, patients who achieved at least a PASI 75 response (PASI score improvement of at least 75% relative to baseline), entered period B and received open-label 40 mg adalimumab every other week.
Croatian: Nakon 16 tjedana terapije, bolesnici u kojih je postignut barem odgovor PASI 75 (poboljšanje PASI rezultata za barem 75% u odnosu na početak terapije) ušli su u razdoblje B (otvoreni dio ispitivanja) i primali po 40 mg adalimumaba svaki drugi tjedan.
English: It is very important that you tell your doctor if your child has ever had tuberculosis, or if he/she has been in close contact with someone who has had tuberculosis.
Croatian: Važno je da liječniku kažete je li Vaše dijete ikada bolovalo od tuberkuloze, odnosno je li bilo u bliskom doticaju s nekim tko je od nje bolovao.
English: • signs and symptoms suggestive of blood disorders such as persistent fever, bruising,
Croatian: • znakove i simptome koji upućuju na poremećaje u krvi poput uporne vrućice, stvaranja modrica,
English: If you have rheumatoid arthritis and you do not receive methotrexate with your Kromeya therapy, your doctor may decide to give Kromeya 40 mg every week or 80 mg every other week.
Croatian: Ako imate reumatoidni artritis i ne dobivate metotreksat zajedno s lijekom Kromeya, Vaš liječnik može odlučiti davati 40 mg lijeka Kromeya svaki tjedan ili 80 mg svaki drugi tjedan.
English: Population pharmacokinetic analyses with data from over 1300 RA patients revealed a trend toward higher apparent clearance of adalimumab with increasing body weight.
Croatian: Populacijske farmakokinetičke analize na temelju podataka dobivenih u više od 1300 bolesnika s reumatoidnim artritisom pokazale su tendenciju da se prividni klirens adalimumaba povećava s bolesnikovom tjelesnom težinom.
English: Your child should not take Kromeya with medicines containing the active substances anakinra or abatacept due to increased risk of serious infection.
Croatian: Vaše dijete ne bi smjelo primjenjivati Kromeya s drugim lijekovima koji sadrže djelatne tvari anakinru ili abatacept zbog povećanog rizika od ozbiljne infekcije.
English: Warning: Do not use the vial if:
Croatian: Upozorenje: Nemojte upotrebljavati štrcaljku ako:
English: TNF-antagonists including adalimumab have been associated in rare instances with new onset or exacerbation of clinical symptoms and/or radiographic evidence of central nervous system demyelinating disease including multiple sclerosis and optic neuritis, and peripheral demyelinating disease, including Guillain-Barré syndrome.
Croatian: U rijetkim su slučajevima antagonisti TNF-a, uključujući adalimumab, bili povezani s pojavom novih ili pogoršanjem postojećih kliničkih simptoma i/ili radiografskih dokaza demijelinizirajuće bolesti središnjeg živčanog sustava, uključujući multiplu sklerozu i optički neuritis, i periferne demijelinizirajuće bolesti, uključujući Guillain-Barréov sindrom.
English: 7.2 Throw away the used syringe with the protected needle and the vial with attached vial adapter into a sharps container.
Croatian: 7.2 Bacite iskorištenu štrcaljku sa zaštićenom iglom i bočicu s pričvršćenim nastavkom za bočicu u spremnik za oštre predmete
English: Week 52 open-label
Croatian: 52. tjedan Otvoreno
English: Week 24 ***,** Statistically significant at p < 0.001, < 0.01 for all comparisons between adalimumab and placebo at weeks 2, 12 and 24
Croatian: 24. tjedan ***, **Statistički značajno uz p<0,001, p<0,01 za sve usporedbe adalimumaba s placebom u 2., 12. i 24. tjednu a
English: Gather supplies and check for damages
Croatian: Skupite pribor i provjerite da nema oštećenja
English: Neither carcinogenicity studies, nor a standard assessment of fertility and postnatal toxicity, were performed with adalimumab due to the lack of appropriate models for an antibody with limited cross-reactivity to rodent TNF and to the development of neutralizing antibodies in rodents.
Croatian: Nisu provedena ispitivanja kancerogenog potencijala ni standardna procjena toksičnosti za plodnost i postnatalne toksičnosti adalimumaba zbog nepostojanja odgovarajućih modela za protutijelo s ograničenom križnom reaktivnošću s TNF-om glodavaca, odnosno stvaranjem neutralizirajućih protutijela u glodavaca.
English: Of those in clinical response at week 4, 48% had been previously exposed to other TNF-antagonists.
Croatian: 48% bolesnika koji su imali klinički odgovor u 4. tjednu već je prije koristilo neki drugi antagonist TNF-a.
English: • a sac in the wall of a major artery, inflammation and clot of a vein, blockage of a blood vessel;
Croatian: • stvaranje komore u stijenci velike arterije, upala vena i stvaranje ugruška, zatvaranje krvnih žila,
English: Thereafter, the usual dose is 40 mg every other week.
Croatian: Nakon toga, uobičajena doza je 40 mg svaki drugi tjedan.