FrancophonIA/ELRC3.0 huggingface dataset:
English: For the same reason you must not take disulfiram or other medicines that reduce alcohol metabolism (e.g. metronidazole) or preparations that contain alcohol (e.g. ritonavir oral solution) or additional propylene glycol while you are taking Agenerase oral solution (see also Do not take Agenerase).
Danish: Af samme grund må du ikke tage disulfiram eller andre lægemidler, som nedsætter nedbrydning af alkohol (f.eks. metronidazol) eller præparater med alkohol (f.eks. ritonavir oral opløsning) eller yderligere propylenglycol, mens du tager Agenerase oral opløsning (se også ”Tag ikke Agenerase”).
English: Agenerase oral solution also contains 4 mg sodium per ml.
Danish: Agenerase oral opløsning indeholder 4 mg natrium pr. ml.
English: Nelfinavir: the AUC, Cmin and Cmax of nelfinavir were increased by 15 %, 14 %, and 12 %, respectively, when given with amprenavir.
Danish: Nelfinavir: AUC, Cmin og Cmax for nelfinavir var øget med henholdsvis 15 %, 14 % og 12 %, når det blev givet med amprenavir.
English: Amprenavir is a substrate of and inhibits CYP3A4.
Danish: Amprenavir er et substrat for og hæmmer af CYP3A4.
English: NAME OF THE MEDICINAL PRODUCT Agenerase 15 mg/ml oral solution Amprenavir
Danish: LÆGEMIDLETS NAVN Agenerase 15 mg/ml oral opløsning Amprenavir
English: Due to the propylene glycol content of the oral solution you should not take disulfiram or other medicines that reduce alcohol metabolism (e.g. metronidazole) or preparations that contain alcohol (e.g. ritonavir oral solution) or additional propylene glycol while you are taking Agenerase oral solution (see Do not take Agenerase ).
Danish: På grund af indholdet af propylenglycol i den orale opløsning bør du ikke tage disulfiram eller andre lægemidler, som nedsætter nedbrydning af alkohol (f.eks. metronidazol), eller præparater, som indeholder alkohol (f.eks. ritonavir oral opløsning) eller yderligere propylenglycol, mens du tager Agenerase oral opløsning (se også Tag ikke Agenerase).
English: The current (July 2006) ANRS AC-11 algorithm for fosamprenavir / ritonavir defines resistance as the presence of the mutations V32I+I47A/V, or I50V, or at least four mutations among: L10F/I/V, L33F, M36I, I54A/L/M/S/T/V, I62V, V82A/C/F/G, I84V and L90M and is associated with increased phenotypic resistance to fosamprenavir with ritonavir as well as reduced likelihood of virological response (resistance).
Danish: Den nuværende (Juli 2006) ANRS AC-11-algoritme for fosamprenavir/ritonavir definerer resistens som tilstedeværelsen af mutationerne V32I+I47A/V, eller I50V eller mindst fire af følgende mutationer: L10F/I/V, L33F, M36I, I54A/L/M/S/T/V, I62V, V82A/C/F/G, I84V og L90M.
English: The use of the following medicines, together with Agenerase, should only take place on the basis of medical advice: anaesthetics (e.g. lidocaine), antibiotics (e.g. rifabutin, clarithromycin, dapsone and erythromycin), antifungals (e.g. ketoconazole, itraconazole), antimalarials (e.g. halofantrine), anticonvulsant medicines (e.g. carbamazepine, phenytoin and phenobarbital), calcium channel blockers (e.g. amlodipine, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine and verapamil), cholesterol lowering medicines (e.g. atorvastatin, lovastatin and simvastatin), erectile dysfunction medicines (e.g. sildenafil and vardenafil), non-nucleoside reverse transcriptase inhibitors (e.g. delavirdine, efavirenz and nevirapine), opioids (e.g. methadone), hormones like oestrogens and progestogens (e.g. hormonal contraceptives such as the ‘pill'), some glucocorticoids (e.g. fluticasone propionate and budesonide), tricyclic antidepressants (i.e. desipramine and nortriptyline), sedative agents (e.g. midazolam administered by injection), paroxetine, and others (e.g. clozapine and loratadine).
Danish: Anvendelse af de følgende lægemidler sammen med Agenerase bør kun ske efter samråd med lægen: Bedøvelsesmidler (f.eks. lidocain), antibiotika (f.eks. rifabutin, clarithromycin, dapson og erythromycin), svampemidler (f.eks. ketoconazol, itraconazol), antimalariamidler (f.eks. halofantrin), krampestillende lægemidler (f.eks. carbamazepin, phenytoin og phenobarbital), kalciumkanalblokkere (f.eks. amlodipin, diltiazem, felodipin, isradipin, nicardipin, nifedipin, nimodipin, nisoldipin og verapemil), kolesterolsænkende lægemidler (f.eks. atorvastatin, lovastatin og simvastatin), lægemidler mod erektil dysfunktion (f.eks. sildenafil og vardenafil), non-nukleosid revers transkriptasehæmmere (f.eks. delavirdin, efavirenz og nevirapin), opioider (f.eks. metadon), hormoner som østrogener og progesteroner (f.eks. hormonelle præventionsmidler såsom p-piller), nogle glukokortikoider (f.eks. fluticasonpropionat og budesonid), tricykliske antidepressiva (f.eks. desipramin og nortriptylin), bedøvelsesmidler (f.eks. midazolam givet som injektion), paroxetin og andre stoffer (f.eks.. clozapin og loratadin).
English: The amprenavir plasma Cmin values achieved with the combination of amprenavir (600 mg twice daily) in combination with Kaletra (400 mg lopinavir + 100 mg ritonavir twice daily) are approximately 4050% lower than when amprenavir (600 mg twice daily) is given in combination with ritonavir 100 mg twice daily.
Danish: Amprenavir plasma Cmin værdier opnået med kombinationen af amprenavir (600 mg 2 gange daglig) og Kaletra (400 mg lopinavir + 100 mg ritonavir 2 gange daglig) var ca. 40-50 % lavere end når amprenavir (600 mg 2 gange daglig) blev givet i kombination med ritonavir (100 mg 2 gange daglig).
English: The mechanism for the hepatocellular adenomas and carcinomas found in these studies has not been elucidated and the significance of the observed effects for humans is uncertain.
Danish: Mekanismen for de hepatocellulære adenoma og carcinomer, som blev fundet i disse undersøgelser er ikke klarlagt og betydningen for mennesker af de observeres effekter er usikker, men data fra kliniske forsøg og fra brug efter markedsføringen om anvendelse hos mennesker tyder på, at disse data har klinisk betydning.
English: Oral/perioral paraesthesia, tremors, sleep disorders Gastrointestinal disorders Very Common:
Danish: Oral/perioral paræstesi, rystelser, søvnforstyrrelser
English: No recommendations can currently be made regarding adjustment of amprenavir dose when amprenavir is co-administered with methadone.
Danish: Der kan ikke gives anbefalinger for dosisjusteringer af amprenavir, når amprenavir indgives samtidig med methadon.
English: Children (4 to 12 years) and patients less than 50 kg body weight: the recommended dose of Agenerase capsules is 20 mg/kg body weight twice a day, in combination with other antiretroviral agents, without exceeding a total daily dose of 2400 mg (see section 5.1).
Danish: Børn (4 til 12 år) og patienter under 50 kg legemsvægt: Den anbefalede dosis Agenerase kapsler er 20 mg/kg legemsvægt 2 gange daglig i kombination med andre antiretrovirale midler, uden at den totale daglige dosis overstiger 2400 mg (se afsnit 5.1).
English: If your doctor decides it is inappropriate for you to take ritonavir, you will need to take increased doses of Agenerase (1200 mg twice a
Danish: Hvis din læge beslutter, at du ikke samtidig skal have ritonavir, skal din dosis forøges (1200 mg 2 gange daglig).
English: Agenerase oral solution, in combination with other antiretroviral agents, is indicated for the treatment of protease inhibitor (PI) experienced HIV-1 infected adults and children above the age of 4 years.
Danish: Agenerase oral opløsning, i kombination med andre antiretrovirale midler, er indiceret til behandling af HIV-1-inficerede voksne og børn over 4 år, som tidligere er behandlet med proteasehæmmere (PI'er).
English: In PI experienced patients receiving Agenerase capsules 600 mg twice daily and low dose ritonavir, 100 mg twice daily, the nature and frequency of adverse events (grade 2-4) and Grade 3/4 laboratory abnormalities were similar to those observed with Agenerase alone, with the exception of elevated triglyceride levels, and elevated CPK levels which were very common in patients receiving Agenerase and low dose ritonavir.
Danish: Hos patienter, som tidligere er behandlet med proteasehæmmere og i dag behandles med Agenerase kapsler 600 mg 2 gange daglig og ritonavir 100 mg 2 gange daglig, var arten og hyppigheden af bivirkningerne (grad 2-4) og grad 3/4 laboratorie abnormaliteterne i lighed med dem observeret for patienter behandlet kun med Agenerase.
English: The use of amprenavir in combination with ritonavir has not been studied in patients with hepatic impairment.
Danish: Brugen af amprenavir i kombination med ritonavir er ikke undersøgt for patienter med nedsat leverfunktion.
English: • Protease inhibitors (PIs)
Danish: • Proteasehæmmere (PI)
English: Amprenavir is primarily metabolised in the liver by CYP3A4.
Danish: Amprenavir metaboliseres primært i leveren af CYP3A4.
English: Ketoconazole / Itraconazole: the AUC and Cmax of ketoconazole were increased by 44 % and 19 % respectively when given with amprenavir alone.
Danish: Ketoconazol/Itraconazol: AUC og Cmax for ketoconazol var øget med henholdsvis 44 % og 19 %, når stoffet blev givet sammen med amprenavir alene.
English: Rash / cutaneous reactions
Danish: Udslæt/hudreaktioner
English: Common: Uncommon:
Danish: Almindelig: Ikke almindelig:
English: The oral solution is clear, pale yellow to yellow with grape, bubblegum and peppermint flavouring.
Danish: Den o rale opløsning er klar, svagt gullig til gul med drue-, tyggegummi- og pebermyntesmagsstof.
English: These soft capsules are oblong, opaque, off white to cream in colour and marked with the code GX CC2.
Danish: Disse bløde kapsler er aflange, uigennemsigtige, off-white til flødefarvede og mærket med koden GX CC2.
English: Agenerase is used in protease inhibitor experienced HIV-1 infected adults and children above the age of 4 years.
Danish: Agenerase bruges til HIV-1-inficerede voksne og børn over 4 år, som tidligere har fået proteasehæmmere.
English: As compared to a non-matched historical control group, co-administration of methadone and amprenavir resulted in a 30%, 27% and 25% decrease in serum amprenavir AUC, Cmax and Cmin respectively.
Danish: Til sammenligning viste samtidig administration af methadon og amprenavir i en historisk ikkematched kontrolgruppe en nedsættelse af serum amprenavir AUC, Cmax og Cmin med henholdsvis 30 %, 27 % og 25 %.
English: CYP3A4 substrates with narrow therapeutic index Agenerase must not be administered concurrently with medicinal products with narrow therapeutic windows containing active substances that are substrates of cytochrome P450 3A4 (CYP3A4).
Danish: Agenerase må ikke administreres samtidig med lægemidler med smalt terapeutisk vindue indeholdende aktive stoffer, der er substrater for cytochrome P4503A4 (CYP3A4).
English: Ketoconazole / Itraconazole: the AUC and Cmax of ketoconazole were increased by 44 % and 19 % respectively when given with amprenavir.
Danish: Ketoconazol/Itraconazol: AUC og Cmax for ketoconazol var øget med henholdsvis 44 % og 19 %, når soffet blev givet sammen med amprenavir.
English: PACKAGE LEAFLET : INFORMATION FOR THE USER Agenerase 150 mg soft capsules Amprenavir
Danish: INDLÆGSSEDDEL: INFORMATION TIL BRUGEREN Agenerase 150 mg bløde kapsler Amprenavir
English: Each Agenerase capsule contains 50 mg of amprenavir.
Danish: Hver Agenerase kapsel indeholder 50 mg amprenavir.
English: In patients with haemophilia Type A and B, there have been reports of increased bleeding while taking protease inhibitors.
Danish: Der har været rapporter om øget blødning hos patienter med hæmofili type A og B, mens de har fået proteasehæmmere.
English: Pack contents : Two bottles each containing 240 soft capsules
Danish: LÆGEMIDDELFORM OG INDHOLDSMÆNGDE (PAKNINGSSTØRRELSE) Pakningen indholder: To beholdere hver med 240 bløde kapsler
English: The benefit of Agenerase oral solution boosted with ritonavir has not been demonstrated either in protease inhibitor naïve patients or protease inhibitor experienced patients.
Danish: Fordelen ved Agenerase oral opløsning i kombination med ritonavir er ikke påvist hos proteasehæmmer-naive patienter og hos patienter, der tidligere er behandlet med proteasehæmmere.
English: These soft capsules are oblong, opaque, off white to cream in colour and marked with the code GX CC1.
Danish: Disse bløde kapsler er aflange, uigennemsigtige, off-white til flødefarvede og mærket med koden GX CC1.
English: Rashes were usually mild to moderate, erythematous or maculopapular cutaneous eruptions, with or without pruritus, occurring during the second week of therapy and resolving spontaneously within two weeks, without discontinuation of treatment with amprenavir.
Danish: Udslættene var sædvanligvis milde til moderate, erytematøse eller makulopapulære kutane eruptioner, med eller uden pruritus.
English: Lipodystrophy
Danish: Osteonekrose
English: Agenerase oral solution is also contraindicated in patients treated with disulfiram or other medicinal products that reduce alcohol metabolism (e.g. metronidazole) and preparations that contain alcohol (e.g. ritonavir oral solution) or additional propylene glycol (see section 4.4and 5.1).
Danish: Agenerase oral opløsning er også kontraindiceret til patienter i behandling med disulfiram eller andre lægemidler, der reducerer alkoholmetabolismen (f.eks. metronidazol) og præparater, som indeholder alkohol (f.eks. ritonavir oral opløsning) eller yderligere propylenglycol (se afsnit 4.4 og 5.1).
English: • Increases in the blood of a substance called bilirubin
Danish: - Forhøjet koncentration i blodet af en substans kaldet bilirubin - Opsvulmen af ansigt, læber og tunge (angioødem)
English: Zidovudine: the AUC and Cmax of zidovudine were increased by 31 % and 40 %, respectively, when given with amprenavir.
Danish: Zidovudin: AUC og Cmax for zidovudin var øget med henholdsvis 31 % og 40 %, når det blev givet med amprenavir.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 20 October 2000
Danish: DATO FOR FØRSTE MARKEDSFØRINGSTILLADELSE/FORNYELSE AF
English: Uncommon side effects (these can affect less than 1 in 100 patients treated)
Danish: Ikke almindelige bivirkninger (disse kan påvirke mindre end 1 ud af 100 patienter)
English: PACKAGE LEAFLET : INFORMATION FOR THE USER Agenerase 50 mg soft capsules Amprenavir
Danish: INDLÆGSSEDDEL: INFORMATION TIL BRUGEREN Agenerase 50 mg bløde kapsler Amprenavir
English: Agenerase, in combination with other antiretroviral agents, is indicated for the treatment of protease inhibitor (PI) experienced HIV-1 infected adults and children above the age of 4 years.
Danish: Agenerase, i kombination med andre antiretrovirale midler, er indiceret til behandling af HIV-1inficerede voksne og børn over 4 år, som tidligere er behandlet med proteasehæmmere (PI'er).
English: The impact of renal impairment on amprenavir elimination should be minimal therefore, no initial dose adjustment is considered necessary.
Danish: Det vurderes derfor, at initial dosisjustering ikke er nødvendig.
English: • Nucleoside analogue reverse transcriptase inhibitors (NRTIs):
Danish: • Nukleosidanalog revers transkriptasehæmmere (NRTI)
English: A.
Danish: KG.
English: Rare side effects (these can affect 1 in 1,000 patients treated)
Danish: Sjældne bivirkninger (disse kan påvirke mindre en 1 ud af 1000 patienter)
English: Co-administration may result in competitive inhibition of the metabolism of these medicinal products and create the potential for serious and/or life-threatening adverse events such as cardiac arrhythmia (e.g. amiodarone, bepridil, quinidine, terfenadine, astemizole, cisapride, pimozide), respiratory depression and /or prolonged sedation (e.g. oral triazolam and oral midazolam (for caution on parenterally administered midazolam, see section 4.5)) or peripheral vasospasm or ischaemia and ischaemia of other tissues, including cerebral or myocardial ischaemia (e.g. ergot derivatives).
Danish: Samtidig administration kan resultere i kompetitiv hæmning af metabolismen af disse lægemidler og skabe grundlag for alvorlige og/eller livstruende bivirkninger såsom hjertearytmier (f.eks. amiodaron, bepridil, quinidin, terfenadin, astemizol, cisaprid, pimozid), respiratorisk depression og/eller forlænget sedation (f.eks. oral triazolam og oral midazolam (se afsnit 4.5 mht parenteral midazolam)), perifere vasospasmer eller iskæmi og iskæmi i andre væv, herunder iskæmi i hjernen henholdsvis hjertet (f.eks. ergotaminderivater).
English: Breast feeding your baby is not recommended while you are taking Agenerase.
Danish: Du bør ikke amme dit barn, hvis du tager Agenerase.
English: What Agenerase looks like and contents of the pack Agenerase 50 mg soft capsules are supplied in plastic bottles containing 480 soft capsules.
Danish: Agenerase 50 mg bløde kapsler findes i plastbeholdere med 480 bløde kapsler.
English: No dose adjustment is necessary for either medicinal product when clarithromycin is administered in combination with amprenavir.
Danish: Dosisjustering er ikke nødvendig for nogen af lægemidlerne, når clarithromycin administreres sammen med amprenavir.
English: For some medicinal products that can cause serious or life-threatening undesirable effects, such as carbamazepine, phenobarbital, phenytoin, tricyclic antidepressants and warfarin (monitor International Normalised Ratio), concentration monitoring is available; this should minimise the risk of potential safety problems with concomitant use.
Danish: For nogle stoffer, der kan forårsage alvorlige eller livstruende bivirkninger, såsom carbamazepin, phenobarbital, phenytoin, tricykliske antidepressiva og warfarin (mål International Normaliseret Ratio) er koncentrationsmålinger tilgængelige.
English: One hundred and sixty-three (163) patients with virus sensitive to Agenerase, at least one other PI, and at least one NRTI were included in PRO30017 substudy A. The primary analysis assessed the noninferiority of APV/r to the SOC PI group with respect to time-weighted average change from baseline (AAUCMB) in plasma viral load (HIV-1 RNA) at week 16 using a non-inferiority margin of 0.4 log10 copies/ml.
Danish: Den primære analyse undersøgte non-inferioriteten af APV/r over for SOC-PI-gruppen med hensyn til den tidsvægtede gennemsnitlige ændring fra baseline (AAUCMB) i plasma viral load (HIV-1-RNA) ved uge 16.
English: The AUC, Cmin and Cmax of amprenavir were increased by 29 %, 27 %, and 47 %, respectively.
Danish: AUC, Cmin og Cmax for amprenavir var øget med henholdsvis 29 %, 27 % og 47 %.
English: Each Agenerase capsule contains 150 mg of amprenavir.
Danish: Hver Agenerase kapsel indeholder 150 mg amprenavir.
English: Do not store above 25°C.
Danish: Må ikke opbevares ved temperaturer over 25 ºC.
English: Didanosine: no pharmacokinetic study has been performed with Agenerase in combination with didanosine, however, due to its antacid component, it is recommended that didanosine and Agenerase should be administered at least one hour apart (see Antacids below).
Danish: På grund af dets indhold af antacida anbefales det dog, at didanosin og Agenerase administreres med mindst én times mellemrum (se antacida nedenfor).
English: Coadministration of fosamprenavir 700 mg with ritonavir 100 mg twice daily and ketoconazole 200 mg once daily increased plasma ketoconazole Cmax by 25 % and increased AUC(0-τ) to values 2.69-fold those observed on administration of ketoconazole 200 mg once daily without concurrent fosamprenavir with ritonavir.
Danish: Samtidig administration af fosamprenavir 700 mg i kombination med ritonavir 100 mg 2 gange daglig og ketoconazol 200 mg én gang daglig forøgede plasma Cmax for ketoconazol med 25 %.
English: Following multiple oral doses of amprenavir (1200 mg twice a day), there is no significant active substance accumulation.
Danish: Der er ingen betydende akkumulering af aktivt stof efter multiple perorale doser af amprenavir (1200 mg 2 gange daglig).
English: - Adults and adolescents (of 12 years of age and older) (greater than 50 kg body weight): the usual dose of Agenerase capsules is 600 mg twice daily with ritonavir 100 mg twice daily, in combination with other antiretroviral medicinal products.
Danish: - Voksne og unge (fra 12 år og derover) (legemsvægt over 50 kg): Den normale dosis Agenerase kapsler er 600 mg 2 gange daglig sammen med ritonavir 100 mg 2 gange daglig i kombination med andre antiretrovirale lægemidler.
English: The AUC, Cmin and Cmax of amprenavir were increased by 33 %, 25 %, and 18 %, respectively.
Danish: AUC, Cmin og Cmax for amprenavir var øget med henholdsvis 33 %, 25 % og 18 %.
English: The AUC, Cmin and Cmax of amprenavir were increased by 18 %, 39 % and 15 %, respectively.
Danish: AUC, Cmin og Cmax for amprenavir var øget med henholdsvis 18 %, 39 % og 15 %.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING BOTTLE LABEL LEAFLET
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN INDRE EMBALLAGE FOLDEUDETIKET
English: - Agenerase oral solution should not be used if you suffer from any liver disease.
Danish: - Hvis du har haft en leversygdom, så tal med lægen om det. - Agenerase oral opløsning bør ikke anvendes, hvis du lider af en leversygdom.
English: SPECIAL STORAGE CONDITIONS Do not store above 30°C.
Danish: SÆRLIGE OPBEVARINGSBETINGELSER Må ikke opbevares over 30°C Hold beholderen tæt tillukket
English: Adults and adolescents of 12 years of age and older (greater than 50 kg body weight): the recommended dose of Agenerase capsules is 600 mg twice daily with ritonavir, 100 mg twice daily, in combination with other antiretroviral agents.
Danish: Voksne og unge på 12 år og derover (over 50 kg legemsvægt): Den anbefalede dosis af Agenerase kapsler er 600 mg 2 gange daglig sammen med 100 mg ritonavir 2 gange daglig og i kombination med andre antiretrovirale midler.
English: The concomitant administration of Agenerase oral solution with disulfiram or other medicinal products that reduce alcohol metabolism (e.g. metronidazole), or preparations that contain alcohol (e.g. ritonavir oral solution) or additional propylene glycol is contraindicated (see sections 4.3and 4.5).
Danish: Samtidig administration af Agenerase oral opløsning og disulfiram eller andre lægemidler, som nedsætter metabolismen af alkohol (f.eks. metronidazol) eller præparater, som indeholder alkohol (f.eks. ritonavir oral opløsning) eller yderligere propylenglycol er kontraindiceret (se afsnit 4.3 og 4.5).
English: This change will decrease the total active substance concentration in the plasma, however the amount of unbound amprenavir, which is the active moiety, is likely to be unchanged.
Danish: Denne ændring vil nedsætte den totale koncentration af aktivt stof i plasma.
English: The benefit of Agenerase boosted with ritonavir has not been demonstrated in PI naïve patients (see section 5.1)
Danish: Fordelen ved Agenerase sammen med en booster dosis af ritonavir er ikke påvist hos patienter, som ikke tidligere er behandlet med proteasehæmmere (se afsnit 5.1).
English: Oblong, opaque, off-white to cream coloured, printed with ‘GX CC1'.
Danish: Aflange, uigennemsigtige, off-white til flødefarvede og mærket "GX CC1".
English: The active substance is amprenavir The Agenerase oral solution contains 15 mg/ml of amprenavir.
Danish: Den orale opløsning indeholder amprenavir 15 mg/ml.
English: Delavirdine: the AUC, Cmax and Cmin of delavirdine were decreased by 61%, 47% and 88% respectively when given with amprenavir.
Danish: Delavirdin: Ved samtidig indgift af delavirdin og amprenavir blev AUC, Cmax og Cmin for delavirdin mindsket med henholdsvis 61 %, 47 % og 88 %, mens AUC, Cmax og Cmin for amprenavir blev øget med henholdsvis 130 %, 40 % og 125 %.
English: The AUC, Cmin and Cmax of amprenavir were decreased by 32 %, 14 % and 37 %, respectively.
Danish: AUC, Cmin og Cmax for amprenavir var nedsat med henholdsvis 32 %, 14 % og 37 %.
English: Amprenavir is 14 % less bioavailable from the oral solution than from the capsules; therefore, Agenerase capsules and Agenerase oral solution are not interchangeable on a milligram per milligram basis.
Danish: Agenerase kapsler og oral opløsning kan derfor ikke erstatte hinanden på basis af milligram til milligram.
English: NAME OF THE MEDICINAL PRODUCT Agenerase 150 mg soft capsules Amprenavir
Danish: LÆGEMIDLETS NAVN Agenerase 150 mg bløde kapsler Amprenavir