FrancophonIA/ELRC3.0 huggingface dataset:
English: (see section 4.5); - riociguat is not recommended (see section 4.5); - vorapaxar is not recommended (see section 4.5); - fusidic acid in osteo-articular infections is not recommended (see section 4.5); - salmeterol is not recommended (see section 4.5); - rivaroxaban is not recommended (see section 4.5).
Slovenian: Kombinacija lopinavirja/ritonavirja s/z: - tadalafilom, uporabljenim za zdravljenje pljučne arterijske hipertenzije, ni priporočljiva (glejte poglavje 4.5); - riociguatom ni priporočljiva (glejte poglavje 4.5); - vorapaksarjem ni priporočljiva (glejte poglavje 4.5); - fusidno kislino pri osteoartikularnih okužbah ni priporočljiva (glejte poglavje 4.5); - salmeterolom ni priporočljiva (glejte poglavje 4.5); - rivaroksabanom ni priporočljiva (glejte poglavje 4.5).
English: Lopinavir/ritonavir should be prescribed by physicians who are experienced in the treatment of HIV infection.
Slovenian: Lopinavir/ritonavir morajo predpisovati zdravniki, ki imajo izkušnje z zdravljenjem okužbe z virusom HIV.
English: When Lopinavir/Ritonavir Mylan is administered concomitantly with bosentan, the efficacy of the HIV therapy should be monitored and patients should be closely observed for bosentan toxicity, especially during the first week of coadministration.
Slovenian: Če je zdravilo Lopinavir/ritonavir Mylan uporabljeno sočasno z bosentanom, je treba učinkovitost zdravljenja HIV kontrolirati, bolnike pa skrbno opazovati glede toksičnosti bosentana, zlasti prvi teden sočasne uporabe.
English: The percentage of patients with confirmed viral rebound ≥50 copies/ml during 48 weeks of follow-up was higher in the paediatric patients receiving lopinavir/ritonavir tablets once daily (12%) than in patients receiving the twice-daily dosing (8%, p = 0.19), mainly due to lower adherence in the once-daily group.
Slovenian: Odstotek bolnikov s potrjenim virusnim preobratom ≥ 50 kopij/ml v obdobju 48 tednov spremljanja je bil večji pri pediatričnih bolnikih, ki so prejemali lopinavir/ritonavir tablete enkrat na dan (12 %) kot pri bolnikih, ki so prejemali odmerek dvakrat na dan (18 %, p = 0.19), zlasti zaradi manjšega sodelovanja bolnikov v skupini, ki je prejemala odmerek enkrat na dan.
English: Amprenavir concentrations are significantly reduced.
Slovenian: fosamprenavir: koncentracija amprenavirja se bistveno zmanjša.
English: If the benefit is considered to outweigh the risk and Lopinavir/Ritonavir Mylan must be used, reduce the ibrutinib dose to 140 mg and monitor patient closely for toxicity.
Slovenian: Če korist odtehta tveganje in je treba zdravilo Lopinavir/ritonavir Mylan uporabiti, zmanjšajte odmerek ibrutiniba na 140 mg in pozorno spremljate bolnika za toksičnost.
English: Lopinavir/ritonavir has been shown in vivo to induce its own metabolism and to increase the biotransformation of some medicinal products metabolised by cytochrome P450 enzymes (including CYP2C9 and CYP2C19) and by glucuronidation.
Slovenian: In vivo je bilo dokazano, da lopinavir/ritonavir inducira svojo lastno presnovo in zvečuje biotransformacijo nekaterih zdravil, ki se presnavljajo z encimi citokroma P450 (vključno s CYP2C9 in CYP2C19) in z glukuronidacijo.
English: M98-940 was an open-label study of a liquid formulation of lopinavir/ritonavir in 100 antiretroviral naïve (44%) and experienced (56%) paediatric patients.
Slovenian: M98-940 je odprta študija tekočega pripravka lopinavirja/ritonavirja pri 100 protiretrovirusno nezdravljenih (44 %) in izkušenih (56 %) pediatričnih bolnikih.
English: Like all medicines, lopinavir/ritonavir can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi lopinavir/ritonavir neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Antiarrhythmics Amiodarone, Dronedarone
Slovenian: Antiaritmiki amiodaron, dronedaron
English: − If a side effect is preventing you from taking lopinavir/ritonavir as directed tell your doctor right away.
Slovenian: - Če vam neželen učinek prepreči, da bi lopinavir/ritonavir jemali, kot vam je bilo naročeno, to takoj povejte zdravniku.
English: If you are taking lopinavir/ritonavir twice a day
Slovenian: Če jemljete lopinavir/ritonavir dvakrat na dan
English: Not applicable.
Slovenian: Navedba ni primerna.
English: 2 tablets (200/50 mg)
Slovenian: 2 tableti (200 mg/50 mg)
English: A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 (e.g. beclomethasone).
Slovenian: V poštev pride zmanjšanje glukokortikoida (ob tem je treba natančno kontrolirati lokalne in sistemske učinke), ali prehod na glukokortikoid, ki ni substrat CYP3A4 (npr. beklometazon).
English: Particular caution must be used when prescribing lopinavir/ritonavir and medicinal products known to induce QT interval prolongation such as: chlorpheniramine, quinidine, erythromycin, clarithromycin.
Slovenian: Posebna previdnost je potrebna pri predpisovanju lopinavirja/ritonavirja in zdravil, ki podaljšujejo interval QT; takšna so npr. klorfeniramin, kinidin, eritromicin, klaritromicin.
English: The median EC50 of lopinavir against isolates with 0 − 3, 4 − 5, 6 − 7 and 8 − 10 mutations at the above amino acid positions was 0.8, 2.7, 13.5 and 44.0-fold higher than the EC50 against wild type HIV, respectively.
Slovenian: Mediana EC50 lopinavirja proti izolatom z 0-3, 4-5, 6-7 oz. 8-10 mutacijami na omenjenih aminokislinskih položajih je bila 0,8-, 2,7-, 13,5- oz. 44,0-krat večja kot EC50 proti divjemu tipu HIV.
English: Recommended number of 100/25 mg tablets twice-daily
Slovenian: Priporočeno število 100 mg/25 mg tablet dvakrat na dan
English: Before prescribing lopinavir/ritonavir 100/25 mg tablets, infants and young children should be assessed for the ability to swallow intact tablets.
Slovenian: Pred predpisovanjem 100 mg/25 mg tablet z lopinavirjem/ritonavirjem, je potrebno pri dojenčkih in mlajših otrocih oceniti sposobnost požiranja celih tablet.
English: It is unknown whether the combination of Lopinavir/Ritonavir Mylan causes a similar increase in trazodone exposure.
Slovenian: Ni znano, ali tudi kombinacija zdravila Lopinavir/ritonavir Mylan podobno poveča izpostavljenost trazodonu.
English: The effective (peak to trough) half-life of lopinavir over a 12 hour dosing interval averaged 5 - 6 hours, and the apparent oral clearance (CL/F) of lopinavir is 6 to 7 l /h.
Slovenian: Efektivni (od vrha do dna) razpolovni čas lopinavirja v 12-urnem odmernem intervalu je bil v povprečju od 5 do 6 ur, navidezni peroralni očistek (CL/F) lopinavirja pa je 6 do 7 l/h.
English: Other side effects that have been reported with lopinavir/ritonavir: yellowing of the skin or whites of eyes (jaundice), severe or life threatening skin rashes and blisters (Stevens-Johnson syndrome and erythema multiforme).
Slovenian: Drugi neželeni učinki, o katerih so poročali pri lopinavirju/ritonavirju so: porumenitev kože ali očesnih beločnic (zlatenica), hudi ali življenje-ogrožujoči izpuščaji in mehurji (Stevens-Johnsonov sindrom in multiformni eritem).
English: A 14C-lopinavir study in humans showed that 89% of the plasma radioactivity after a single 400/100 mg lopinavir/ritonavir dose was due to parent active substance.
Slovenian: Študija s 14C-lopinavirjem pri ljudeh je pokazala, da gre 89 % radioaktivnosti v plazmi po enkratnem odmerku 400 mg/100 mg lopinavirja/ritonavirja na račun matične zdravilne učinkovine.
English: Ranitidine: ↔
Slovenian: ranitidin: ↔
English: Adequate exposure to lopinavir/ritonavir may be achieved when a higher dose of lopinavir/ritonavir is used but this is associated with a higher risk of liver and gastrointestinal toxicity.
Slovenian: Zadostno izpostavljenost kombinaciji lopinavir/ritonavir se lahko doseže z uporabo višjega odmerka lopinavirja/ritonavirja, vendar je to povezano z večjim tveganjem za jetrno in gastrointestinalno toksičnost.
English: The choice of lopinavir/ritonavir to treat protease inhibitor experienced HIV-1 infected patients should be based on individual viral resistance testing and treatment history of patients (see sections 4.4 and 5.1).
Slovenian: Izbira lopinavirja/ritonavirja za zdravljenje s HIV-1 okuženih in z zaviralci proteaz izkušenih bolnikov mora temeljiti na individualnem preizkusu odpornosti virusa in anamnezi bolnikovega zdravljenja (glejte poglavji 4.4 in 5.1).
English: Therefore, Lopinavir/Ritonavir Mylan can be started safely 2 weeks after cessation of St John's wort.
Slovenian: Zato je zdravilo Lopinavir/ritonavir Mylan mogoče varno začeti uporabljati 2 tedna po prenehanju jemanja šentjanževke.
English: Difference [95% CI]
Slovenian: Razlik a [95 % IZ]
English: Tadalafil:
Slovenian: tadalafil tadalafil:
English: Based on known metabolic profiles, clinically significant interactions are not expected between Lopinavir/Ritonavir Mylan and dapsone, trimethoprim/sulfamethoxazole, azithromycin or fluconazole.
Slovenian: Na temelju znanih presnovnih značilnosti ni pričakovati klinično pomembnega medsebojnega delovanja zdravila Lopinavir/ritonavir Mylan in dapsona, trimetoprima/sulfametoksazola, azitromicina ali flukonazola.
English: If Lopinavir/Ritonavir Mylan is coadministered with parenteral midazolam, it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Slovenian: Če je zdravilo Lopinavir/ritonavir Mylan uporabljeno sočasno s parenteralnim midazolamom, je to potrebno izvesti v enoti za intenzivno nego (EIN) ali podobnem okolju, ki omogoča natančno kliničen nadzor in ustrezno medicinsko ukrepanje v primeru depresije dihanja in/ali dolgotrajne sedacije.
English: While rosuvastatin is poorly metabolised by CYP3A4, an increase of its plasma concentrations was observed.
Slovenian: Ker se rosuvastatin slabo presnavlja s CYP3A4, so opažali povečanje koncentracije v plazmi.
English: 400/100 mg 500/125 mg
Slovenian: 400 mg/100 mg 500 mg/125 mg
English: − If you take sildenafil or tadalafil and lopinavir/ritonavir together, you may be at risk of side effects such as low blood pressure, passing out, visual changes and penile erection lasting more than 4 hours.
Slovenian: - Če sildenafil ali tadalafil in lopinavir/ritonavir jemljete sočasno, vas lahko ogrožajo neželeni učinki kot npr. nizek krvni tlak, omedlevica, motnje vida in erekcija, ki traja več kot 4 ure.
English: Rifabutin, 150 mg QD Rifabutin (parent drug and active 25O-desacetyl metabolite):
Slovenian: rifabutin, 150 mg enkrat na dan rifabutin (matično zdravilo in aktivni 25-O-dezacetilni presnovek):
English: No data are available in patients with severe hepatic impairment.
Slovenian: Pri bolnikih s hudo jetrno okvaro podatkov ni na voljo.
English: If the use of atorvastatin is considered strictly necessary, the lowest possible dose of atorvastatin should be administered with careful safety monitoring (see section 4.4).
Slovenian: Če je uporaba atorvastatina res potrebna, je treba uporabiti najmanjši možni odmerek atorvastatina in potrebno je natančno varnostno spremljanje (glejte poglavje 4.4).
English: Adverse reactions from clinical trials and post-marketing experience in adult and paediatric patients:
Slovenian: Neželeni učinki v kliničnih študijah in v obdobju trženja zdravila pri odraslih in pediatričnih bolnikih:
English: - This medicine has been prescribed for you or your child only.
Slovenian: - Zdravilo je bilo predpisano vam ali vašemu otroku osebno in ga ne smete dajati drugim.
English: 300/75 mg
Slovenian: 300 mg/75 mg
English: How much Lopinavir/Ritonavir Mylan should be taken and when?
Slovenian: Koliko zdravila Lopinavir/ritonavir Mylan naj uporabim in kdaj
English: Unchanged lopinavir accounted for approximately 2.2% and 19.8% of the administered dose in urine and faeces, respectively.
Slovenian: Nespremenjeni lopinavir predstavlja v urinu približno 2,2 %, v blatu pa približno 19,8 % uporabljenega odmerka.
English: In the QD group, 6/75 (8%) patients demonstrated new primary protease inhibitor mutations (codons 30, 32, 48, 50, 82, 84, 90), as did 12/77 (16%) patients in the BID group.
Slovenian: V skupini, ki je prejemala zdravilo 1 x dnevno, je 6/75 (8 %) bolnikov pokazalo nove primarne mutacije proteaznih inhibitorjev (kodoni 30, 32, 48, 50, 82, 84, 90), kot tudi 12/77 (16 %) bolnikov v skupini, ki je prejemala zdravilo 2 x dnevno.
English: A more pronounced effect on DM-6705 exposure may be observed during prolonged co-administration with lopinavir/ritonavir.
Slovenian: Bolj izrazit učinek na izpostavljenost DM-6705 se lahko opazi med podaljšano sočasno uporabo z lopinavirjem/ritonavirjem.
English: − Symptoms of dizziness, lightheadedness, fainting or sensation of abnormal heartbeats.
Slovenian: - Simptomi omotičnosti, vrtoglavice, omedlevice ali občutek nepravilnosti srčnega ritma.
English: In patients starting or stopping Lopinavir/Ritonavir Mylan while currently taking maintenance dose of lamotrigine: lamotrigine dose may need to be increased if Lopinavir/Ritonavir Mylan is added, or decreased if Lopinavir/Ritonavir Mylan is discontinued; therefore plasma lamotrigine monitoring should be conducted, particularly before and during 2 weeks after starting or stopping Lopinavir/Ritonavir Mylan, in order to see if lamotrigine dose adjustment is needed.
Slovenian: Bolniki, ki jemljejo vzdrževalni odmerek lamotrigina in so začeli ali prenehali jemati zdravilo Lopinavir/ritonavir Mylan: Pri uvedbi zdravila Lopinavir/ritonavir Mylan bo morda potrebno povečati odmerek lamotrigina oz ga zmanjšati, če je zdravilo Lopinavir/ritonavir Mylan ukinjeno; zato je potrebno nadzorovati koncentracijo lamotrigina v plazmi, še posebno dva tedna pred in po uvedbi ali prenehanju jemanja zdravila Lopinavir/ritonavir Mylan, da se ugotovi, ali je potrebno odmerek lamotrigina prilagoditi ali ne.
English: Virologic Response of Study Subjects at Week 48 Study 802 QD
Slovenian: Virološk i odziv preisk ovancev v študiji 48. teden študije 802 Enk ratnadan Dvakratnadan
English: Sixty-one patients completed the study (35 patients received the recommended 400/100 mg twice daily dose throughout the study).
Slovenian: Študijo je dokončalo 61 bolnikov (35 bolnikov je ves čas študije dobivalo priporočeni odmerek 400 mg/100 mg dvakrat na dan).
English: - Your doctor has prescribed lopinavir/ritonavir to help to control your Human Immunodeficiency Virus (HIV) infection.
Slovenian: - Zdravnik vam je predpisal lopinavir/ritonavir za obvladovanje okužbe z virusom humane imunopomanjkljivosti (HIV).
English: In case of co-administration of Lopinavir/Ritonavir Mylan with contraceptives containing ethinyl oestradiol (whatever the contraceptive formulation e.g. oral or patch), additional methods of contraception must be used.
Slovenian: Med sočasno uporabo zdravila Lopinavir/ritonavir Mylan s kontraceptivi, ki vsebujejo etinilestradiol (ne glede na formulacijo kontraceptiva, npr. peroralni ali obliž), je treba uporabiti dodatne načine kontracepcijske zaščite.
English: Lopinavir/ritonavir is an antiretroviral medicine.
Slovenian: Lopinavir/ritonavir je protivirusno zdravilo.
English: Potential for serious and/or lifethreatening reactions in patients with renal and/or hepatic impairment (see sections 4.4 and 4.5).
Slovenian: Možnost za resne in/ali življenjsko ogrožajoče reakcije pri bolnikih z okvaro ledvic in/ali jeter (glejte poglavji 4.4 in 4.5).
English: What Lopinavir/Ritonavir Mylan is and what it is used for What you need to know before you or your child takes Lopinavir/Ritonavir Mylan How to take Lopinavir/Ritonavir Mylan
Slovenian: Kaj je zdravilo Lopinavir/ritonavir Mylan in za kaj ga uporabljamo Kaj morate vedeti, preden boste vi ali vaš otrok vzeli zdravilo Lopinavir/ritonavir Mylan Kako jemati zdravilo Lopinavir/ritonavir Mylan Možni neželeni učinki
English: When co-administered with Lopinavir/Ritonavir Mylan, sildenafil doses must not exceed 25 mg in 48 hours and tadalafil doses must not exceed 10 mg every 72 hours.
Slovenian: Med sočasno uporabo z zdravilom Lopinavir/ritonavir Mylan odmerek sildenafila ne sme preseči 25 mg v 48 urah in odmerek tadalafila ne 10 mg na 72 ur.
English: Children were eligible when they were aged <18 years, ≥15 kg in weight, receiving cART that included lopinavir/ritonavir, HIV-1 ribonucleic acid (RNA) <50 copies/ml for at least 24 weeks and able to swallow tablets.
Slovenian: Otroci so bili primerni, če so bili: stari < 18 let, so tehtali ≥ 15 kg, so prejemali kombinirano protiretrovirusno zdravljenje, ki je vključevalo lopinavir/ritonavir, so imeli HIV-1 ribonukleinske kisline (RNA) <50 kopij/ml najmanj 24 tednov in so bili zmožni pogoltniti tablete.
English: If treatment with a HMG-CoA reductase inhibitor is indicated, pravastatin or fluvastatin is recommended (see section 4.5).
Slovenian: Če je indicirano zdravljenje z zaviralcem HMG-CoA reduktaze, sta priporočljiva pravastatin ali fluvastatin (glejte poglavje 4.5).
English: Particular caution should be used when prescribing sildenafil or tadalafil for the treatment of erectile dysfunction in patients receiving lopinavir/ritonavir.
Slovenian: Posebna previdnost je potrebna pri predpisovanju sildenafila ali tadalafila za zdravljenje erektilne disfunkcije bolnikom, ki dobivajo lopinavir/ritonavir.
English: Thyroid hormone replacement therapy Levothyroxine
Slovenian: Nadomestno zdravljenje s ščitničnimi hormoni levotiroksin
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymtomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Slovenian: Pri z virusom HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - ''combination antiretroviral therapy'') nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične patogene in povzroči resna klinična stanja ali poslabšanje simptomov.
English: If treatment with an HMG-CoA reductase inhibitor is indicated, fluvastatin or pravastatin is recommended.
Slovenian: Če je indicirano zdravljenje z zaviralcem HMG-CoA reduktaze, sta priporočljiva pravastatin ali fluvastatin.
English: Given the pharmacokinetic interaction between lopinavir/ritonavir and tenofovir (see section 4.5), the results of this study might not be strictly extrapolable when other backbone regimens are used with lopinavir/ritonavir.
Slovenian: Glede na farmakokinetične interakcije med lopinavirjem/ritonavirjem in tenofovirjem (glejte poglavje 4.5) rezultatov te študije morda niso mogoče strogo ekstrapolirati na uporabo lopinavirja/ritonavirja z drugimi osnovnimi shemami.
English: Adult patients who have not previously taken other antiviral medicines can also take lopinavir/ritonavir tablets once daily as an 800 mg/200 mg dose.
Slovenian: Odrasli bolniki, ki predhodno še niso dobivali drugih protiretrovirusnih zdravil, lahko tablete lopinavirja/ritonavirja jemljejo tudi enkrat na dan v odmerku 800 mg/200 mg.
English: At week 48, the efficacy and safety with twice-daily dosing (n=87) in the paediatric population given lopinavir/ritonavir 100 mg/25 mg tablets was consistent with the efficacy and safety findings in previous adult and paediatric studies using lopinavir/ritonavir twice daily.
Slovenian: V 48. tednu sta bili učinkovitost in varnost odmerjanja dvakrat na dan v pediatrični populaciji (n = 87), ki je prejemala lopinavir/ritonavir 100 mg/25 mg tablete skladni z ugotovitvami o učinkovitosti in varnosti pri predhodnih študijah pri odraslih in otrocih, kjer so uporabljali kombinacijo lopinavir/ritonavir dvakrat na dan.
English: * The tablets must not be chewed, broken or crushed.
Slovenian: * Tablet ni dovoljeno žvečiti, lomiti ali drobiti.
English: Isolates retained susceptibility to tipranavir with a median increase of IC50 in baseline and rebound isolates of 1.9- and 1.8-fold, respectively, compared to wild type virus.
Slovenian: Izolati so ohranili občutljivost za tipranavir s srednjim (mediana) povečanjem IC50 v izhodiščnih izolatih za 1,9-krat in izolatih po preobratu za 1,8-krat v primerjavi z divjim tipom virusa.
English: It is therefore important that you remain under the supervision of your doctor while taking lopinavir/ritonavir.
Slovenian: Zato je pomembno, da med jemanjem lopinavirja/ritonavirja ostanete pod nadzorom svojega zdravnika.
English: Cardiac events have been reported with lopinavir/ritonavir in preclinical studies; therefore, the potential cardiac effects of lopinavir/ritonavir cannot be currently ruled out (see sections 4.8 and 5.3).
Slovenian: V predkliničnih raziskavah lopinavirja/ritonavirja so poročali o kardialnih incidentih, zato možnih učinkov lopinavirja/ritonavirja na srce trenutno ni mogoče izključiti (glejte poglavji 4.8 in 5.3).
English: One-hundred thirteen nelfinavir-treated patients and 74 lopinavir/ritonavir-treated patients had an HIV RNA above 400 copies/ml while on treatment from Week 24 through Week 96.
Slovenian: 113 bolnikov, zdravljenih z nelfinavirjem in 74 bolnikov, zdravljenih z lopinavirjem/ritonavirjem je imelo HIV RNA nad 400 kopij/ml, medtem ko so prejemali zdravljenje od 24.tedna do 96.tedna.
English: Antihistamines Astemizole Terfenadine
Slovenian: Antihistaminiki astemizol terfenadin
English: In HIV-infected patients with mild to moderate hepatic impairment, an increase of approximately 30% in lopinavir exposure has been observed but is not expected to be of clinical relevance (see section 5.2).
Slovenian: Pri bolnikih, okuženih z virusom HIV in blago do zmerno jetrno okvaro so opazili za približno 30% večjo izpostavljenost lopinavirju, vendar ni pričakovati, da bi to bilo klinično pomembno (glejte poglavje 5.2).
English: Lopinavir binds to both alpha1-acid glycoprotein (AAG) and albumin however, it has a higher affinity for AAG.
Slovenian: Lopinavir se veže na alfa-1-kisli glikoprotein (AKG) in na albumin, vendar ima večjo afiniteto za AKG.
English: The 4-oxo and 4hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.
Slovenian: Glavna presnovka s protivirusnim delovanjem sta epimerni par 4-okso- in 4-hidroksimetabolita, vendar pomenita le neznaten delež skupne radioaktivnosti v plazmi.
English: After 48 weeks of treatment with lopinavir/ritonavir, efavirenz and nucleoside reverse transcriptase inhibitors, plasma HIV RNA ≤ 400 copies/ml was observed in 93% (25/27), 73% (11/15), and 25% (2/8) of patients with < 10-fold, 10 to 40-fold, and > 40-fold reduced susceptibility to lopinavir at baseline, respectively.
Slovenian: Po 48 tednih zdravljenja z lopinavirjem/ritonavirjem, efavirenzem in nukleozidnimi zaviralci reverzne transkriptaze so HIV RNA v plazmi ≤ 400 izvodov/ml ugotovili pri 93 % (25/27), 73 % (11/15), in 25 % (2/8) bolnikov z < 10-krat, 10- do 40-krat oz. > 40-krat zmanjšano izhodiščno občutljivostjo za lopinavir.
English: Pimozide
Slovenian: pimozid
English: Telaprevir 750 mg three times daily
Slovenian: telaprevir 750 mg trikrat na dan telaprevir:
English: Concomitant use of Lopinavir/Ritonavir Mylan with rilpivirine causes an increase in the plasma concentrations of rilpivirine, but no dose adjustment is required.
Slovenian: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan z rilpivirinom povzroči povečanje plazemskih koncentracij rilpivirina, vendar prilagoditev odmerka ni potrebna.
English: Adult patients who have previously taken other antiviral medicines can take lopinavir/ritonavir tablets once daily as an 800 mg/200 mg dose if their doctor decides it is appropriate.
Slovenian: Odrasli bolniki, ki predhodno dobivali druga protiretrovirusna zdravila, lahko tablete lopinavirja/ritonavirja jemljejo enkrat na dan v odmerku 800 mg/200 mg, če njihov zdravnik presodi, da je to primerno.