FrancophonIA/ELRC3.0 huggingface dataset:
English: Distribution Quetiapine is approximately 83% bound to plasma proteins.
Croatian: Oko 83% kvetiapina vezano je za proteine plazme.
English: As Seroquel XR has several indications, the safety profile should be considered with respect to the individual patient's diagnosis and the dose being administered.
Croatian: Budući da Seroquel XR ima nekoliko indikacija, sigurnosni profil lijeka mora se razmotriti uzimajući u obzir dijagnozu pojedinog bolesnika i dozu koja se primjenjuje.
English: • If you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel (see section 6: Further information)
Croatian: • ako ste alergični (preosjetljivi) na kvetiapin ili bilo koji drugi sastojak Seroquela (naveden u dijelu 6.)
English: Depending on the clinical response and tolerability of the individual patient, the dose may be adjusted within the range 150 to 750 mg/day.
Croatian: Ovisno o kliničkom odgovoru i podnošljivosti kod pojedinog bolesnika, doza se može prilagoditi u rasponu od 150 do 750 mg dnevno.
English: These elevations were usually reversible on continued quetiapine treatment.
Croatian: Ta su povišenja obično reverzibilna tijekom daljnje primjene kvetiapina.
English: • Worsening of pre-existing diabetes.
Croatian: • pogoršanje postojeće šećerne bolesti
English: • Feeling weak, fainting (may lead to falls).
Croatian: • osjećaj slabosti, nesvjestica (može dovesti do padova)
English: • Azole medicines (for fungal infections).
Croatian: • lijekove iz skupine azola (za suzbijanje gljivičnih infekcija),
English: The rate of dose titration may need to be slower, and the daily therapeutic dose lower, than that used in younger patients, depending on the clinical response and tolerability of the individual patient.
Croatian: Brzina titriranja doze možda će trebati biti sporija, a dnevna terapijska doza niža od one koja se primjenjuje u mlađih bolesnika, ovisno o kliničkom odgovoru i podnošljivosti pojedinog bolesnika.
English: Increases in blood pressure were reported in children and adolescents and increased appetite, extrapyramidal symptoms and elevations in serum prolactin were reported with higher frequency in children and adolescents than in adult patients (see sections 4.4 and 4.8).
Croatian: Povišenje krvnog tlaka prijavljeno je u djece i adolescenata, a povećan apetit, ekstrapiramidni simptomi i povećanje serumskog prolaktina prijavljeni su s većom učestalošću u djece i adolescenata nego u odraslih bolesnika (vidjeti dijelove 4.4 i 4.8).
English: What Seroquel looks like and contents of the pack
Croatian: Kako Seroquel izgleda i sadržaj pakiranja
English: Quetiapine and norquetiapine exhibit affinity for brain serotonin (5HT2) and dopamine D1- and D2- receptors.
Croatian: Kvetiapin i norkvetiapin pokazuju afinitet za moždane serotoninske (5HT2) receptore i dopaminske D1 i D2 receptore.
English: If signs and symptoms of tardive dyskinesia appear, dose reduction or discontinuation of quetiapine should be considered.
Croatian: Tardivna diskinezija: Pojave li se znakovi i simptomi tardivne diskinezije, mora se razmotriti smanjenje doze ili prekid uzimanja kvetiapina.
English: In such an event, quetiapine should be discontinued and appropriate medical treatment given.
Croatian: Pri pojavi tih znakova mora se prekinuti liječenje kvetiapinom i primijeniti odgovarajuće medicinsko liječenje.
English: • High blood pressure medicines.
Croatian: • lijekove za liječenje povišenog krvnog tlaka,
English: In cases of severe signs, the possibility of multiple drug involvement should be considered, and intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system.
Croatian: U slučajevima teških znakova potrebno je uzeti u obzir mogućnost unosa više različitih lijekova te se preporučuju mjere intenzivne skrbi, uključivši uspostavu i održavanje prohodnosti dišnih putova, osiguranje primjerene oksigenacije i ventilacije te praćenje i potporne mjere kardiovaskularnom sustavu.
English: Constipation represents a risk factor for intestinal obstruction.
Croatian: Konstipacija predstavlja faktor rizika za opstrukciju crijeva.
English: Asymptomatic elevations (shift from normal to > 3X ULN at any time) in serum transaminase (ALT, AST) or gamma-GT-levels have been observed in some patients administered quetiapine.
Croatian: Asimptomatske povećane vrijednosti (pomak sa normalnih na >3X ULN u bilo kojem trenutku) serumskih transaminaza (ALT, AST) ili gama-GT primijećene su u nekih bolesnika koji su uzimali kvetiapin.
English: A 26-week open-label extension to the acute trials (n=380 patients), with Seroquel flexibly dosed at 400800 mg/day, provided additional safety data.
Croatian: U otvorenom produžetku akutnih ispitivanja (n=380 bolesnika) u trajanju od 26 tjedana, s fleksibilnim doziranjem Seroquela u rasponu od 400 do 800 mg dnevno, dobiveni su dodatni sigurnosni podaci.
English: • Decrease in the amount of red blood cells
Croatian: • smanjenje količine crvenih krvnih stanica
English: In patients who responded to quetiapine, when comparing continued treatment with quetiapine to switching to lithium, the results indicated that a switch to lithium treatment does not appear to be associated with an increased time to recurrence of a mood event.
Croatian: Kada se u bolesnika kod kojih je došlo do odgovora na kvetiapin uspoređivao nastavak liječenja kvetiapinom s prelaskom na liječenje litijem, rezultati su pokazali da prelazak na liječenje litijem čini se nije povezan s produženjem vremena do ponovne pojave epizode poremećaja raspoloženja.
English: The incidence of shifts to >0.5-<1.0 x 109/L was the same (0.2%) in patients treated with quetiapine as with placebo-treated patients.
Croatian: Incidencija pomaka na >0,5-<1,0 x 109/L je bila jednaka (0,2%) kod bolesnika liječenih kvetiapinom kao i kod bolesnika liječenih placebom.
English: Interactions: See also section 4.5.
Croatian: Interakcije: Vidjeti i dio 4.5.
English: Quetiapine treatment has been associated with somnolence and related symptoms, such as sedation (see Section 4.8).
Croatian: Liječenje kvetiapinom je povezano sa somnolencijom i povezanim simptomima, kao što je sedacija (vidjeti dio 4.8).
English: Elderly patients should be started on 50 mg/day.
Croatian: U starijih bolesnika mora se započeti dozom od 50 mg dnevno.
English: These include changes in the amount of certain fats (triglycerides and total cholesterol) or sugar in the blood, changes in the amount of thyroid hormones in your blood, increased liver enzymes, decreases in the number of certain types of blood cells, decrease in the amount of red blood cells, increased blood creatine phosphokinase (a substance in the muscles), decrease in the amount of sodium in the blood and increases in the amount of the hormone prolactin in the blood.
Croatian: Ovo uključuje promjene u vrijednostima određenih masnoća (triglicerida i ukupnog kolesterola) ili šećera u krvi, promjene količine hormona štitnjače u Vašoj krvi, povišene jetrene enzime, smanjenje broja određenih vrsta krvnih stanica, smanjenje količine crvenih krvnih stanica, povišenje kreatin fosfokinaze (tvar iz mišića) u krvi, smanjenje količine natrija u krvi i porast količine hormona prolaktina u krvi.
English: Approximately 73% of a radiolabelled drug was excreted in the urine and 21% in the faeces with less than 5% of the total radioactivity representing unchanged drug-related material.
Croatian: Oko 73% radioizotopom obilježenog lijeka izluči se mokraćom, a 21% fecesom, pri čemu je udio nepromijenjenog lijeka u ukupnoj radioaktivnosti biološkog materijala manji od 5%.
English: For the treatment of schizophrenia
Croatian: Za liječenje shizofrenije
English: 120 film-coated tablets (150 mg and 300 mg tablets only) 180 film-coated tablets (150 mg and 300 mg tablets only) 240 film-coated tablets (150 mg and 300 mg tablets only)
Croatian: 120 filmom obloženih tableta (samo za tablete od 150 mg i 300 mg) 180 filmom obloženih tableta (samo za tablete od 150 mg i 300 mg) 240 filmom obloženih tableta (samo za tablete od 150 mg i 300 mg)
English: For more convenient dosing, patients who are currently being treated with divided doses of immediate release Seroquel tablets may be switched to Seroquel XR at the equivalent total daily dose taken once daily.
Croatian: Radi praktičnijeg doziranja, bolesnike koji se trenutno liječe podijeljenim dozama Seroquel tableta s trenutnim oslobađanjem djelatne tvari (engl. immediate-release, zaštićeni naziv Seroquel) može se prebaciti na Seroquel XR, primijenjen u ekvivalentnoj ukupnoj jednokratnoj dnevnoj dozi.
English: If you are pregnant or breast feeding, think you may be pregnant or planning to have a baby ask your doctor for advice before taking Seroquel.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego uzmete Seroquel.
English: Given the primary central nervous system effects of quetiapine, quetiapine should be used with caution in combination with other centrally acting medicinal products and alcohol.
Croatian: Budući da kvetiapin prvenstveno djeluje na središnji živčani sustav, kvetiapin se mora s oprezom uzimati u kombinaciji s ostalim lijekovima koji djeluju na središnji živčani sustav, kao i s alkoholom.
English: Quetiapine should be discontinued in patients with a neutrophil count <1.0 X 109/L.
Croatian: Primjena kvetiapina mora se prekinuti kod bolesnika s brojem neutrofila <1,0 X 109/L.
English: Seroquel XR achieves peak quetiapine and norquetiapine plasma concentrations at approximately 6 hours after administration (Tmax).
Croatian: Pri primjeni Seroquela XR, vršne koncentracije kvetiapina i norkvetiapina u plazmi, dosežu se otprilike 6 sati nakon primjene (Tmax).
English: Do not take Seroquel XR if you are taking any of the following medicines:
Croatian: Nemojte uzimati Seroquel XR ukoliko uzimate bilo koji od sljedećih lijekova:
English: Cases of venous thromboembolism (VTE) have been reported with antipsychotic drugs.
Croatian: Venska tromboembolija (VTE) Tijekom primjene antipsihotika zabilježeni su slučajevi venske tromboembolije (VTE).
English: In short-term, placebo-controlled clinical trials in schizophrenia and bipolar mania the aggregated incidence of extrapyramidal symptoms was similar to placebo (schizophrenia: 7.8% for quetiapine and 8.0% for placebo; bipolar mania: 11.2% for quetiapine and 11.4% for placebo).
Croatian: U kratkoročnim, placebom kontroliranim kliničkim ispitivanjima shizofrenije i bipolarne manije skupna incidencija ekstrapiramidnih simptoma bila je slična placebu (shizofrenija: 7,8% za kvetiapin i 8,0% za placebo; bipolarna manija: 11,2% za kvetiapin i 11,4% za placebo).
English: The efficacy and safety of Seroquel was studied in a 3-week placebo controlled study for the treatment of mania (n= 284 patients from the US, aged 10-17).
Croatian: U 3-tjednom placebom kontroliranom ispitivanju ispitivana je djelotvornost i sigurnost primjene Seroquela u liječenju manije (n=284 bolesnika iz SAD-a, 10-17 godina).
English: The following symptoms which can represent withdrawal may occur in newborn babies of mothers that have used Seroquel in the last trimester (last three months of their pregnancy): shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding.
Croatian: Sljedeći simptomi, koji mogu biti znakovi ustezanja (prekida primjene lijeka), mogu se pojaviti kod novorođenčadi majki koje su koristile Seroquel u zadnjem trimestru (zadnja tri mjeseca trudnoće): tresavica, ukočenost i/ili slabost mišića, pospanost, uznemirenost, problemi s disanjem i hranjenjem.
English: Weight gain has been seen in patients taking Seroquel.
Croatian: Povećanje tjelesne težine je primijećeno kod bolesnika koji uzimaju Seroquel.
English: Marketing Authorisation Holder and Manufacturer <[To be completed nationally]>
Croatian: Nositelj odobrenja za staljanje lijeka u promet i proizvođač <[Ispunjava država članica]>
English: Shifts in WBCs are defined as ≤ 3X10^9 cells/L at any time.
Croatian: Pomaci u leukocitima su definirani kao ≤ 3 X 10^9 stanica/L u bilo kojem trenutku.
English: In a specific interaction study in psychotic patients, however, no increase in the cytochrome P450 activity was found after administration of quetiapine.
Croatian: U posebnom ispitivanju interakcija, u psihotičnih bolesnika, nije dokazana povećana aktivnost citokroma P450 nakon primjene kvetiapina.
English: Both in mania and schizophrenia higher doses resulted in numerically lower response rates.
Croatian: I kod bolesnika s manijom i sa shizofrenijom više doze rezultirale su brojčano nižom stopom odgovora.
English: Possible risk factors for neutropenia include pre-existing low white blood cell count (WBC) and history of drug induced neutropenia.
Croatian: Mogući faktori rizika za pojavu neutropenije su postojeći niži broj bijelih krvnih stanica (leukocita), kao i neutropenija uzrokovana lijekovima u anamnezi bolesnika.
English: Angioedema StevensJohnson syndrome5
Croatian: Poremećaji kože i potkožnog tkiva angioedem StevensJohnsonov sindrom5
English: 6.5 Nature and contents of container Polychlorotrifluoroethylene and polyvinylchloride with aluminium blister
Croatian: 6.5 Vrsta i sadržaj spremnika Poliklorotrifluoroetilen i polivinilklorid aluminijski blisteri.
English: PHARMACEUTICAL FORM AND CONTENTS 8 film-coated tablets
Croatian: OBLIK I SADRŽAJ 8 filmom obloženih tableta Kombinirano pakiranje
English: Concomitant use of quetiapine and thioridazine caused an increased clearance of quetiapine with approx. 70%.
Croatian: Istodobna uporaba kvetiapina i tioridazina povećala je, međutim, klirens kvetiapina za približno 70%.
English: Abnormal dreams and nightmares, Suicidal ideation and suicidal behaviour
Croatian: Psihijatrijski poremećaji neuobičajeni snovi i noćne more, suicidalne misli i suicidalno ponašanje20
English: A retrospective study of children and adolescents who received valproate, quetiapine, or both, found a higher incidence of leucopenia and neutropenia in the combination group versus the monotherapy groups.
Croatian: Retrospektivna studija kod djece i adolescenata koji su primali valproat, kvetiapin ili oba lijeka, pokazala je veću incidenciju leukopenije i neutropenije u skupini koja je primala kombinaciju tih lijekova u odnosu na monoterapijske skupine.
English: The incidence of somnolence was higher in the SEROQUEL XR with lithium add-on group (12.7%) compared to the SEROQUEL XR with the placebo add-on group (5.5%).
Croatian: Incidencija somnolencije bila je veća u skupini koja je primala Seroquel XR s litijem (12,7%) nego u skupini koja je primala Seroquel XR s placebom (5,5%).
English: The average molar dose fraction of free quetiapine and the active human plasma metabolite norquetiapine is <5% excreted in the urine.
Croatian: Prosječni molarni udio slobodnog kvetiapina i aktivnog metabolita iz ljudske plazme, norkvetiapina, izlučenog u urinu je manji od 5%.
English: Patients treated with any antipsychotic agent including quetiapine, should be observed for signs and symptoms of hyperglycaemia, (such as polydipsia, polyuria, polyphagia and weakness) and patients with diabetes mellitus or with risk factors for diabetes mellitus should be monitored regularly for worsening of glucose control.
Croatian: Bolesnike liječene bilo kojim antipsihotikom, uključujući kvetiapin, mora se promatrati kako bi se uočili znakovi i simptomi hiperglikemije (kao što su polidipsija, poliurija, polifagija i slabost), a bolesnike sa šećernom bolesti ili s rizičnim faktorima za šećernu bolest mora se redovito pratiti zbog pogoršanje kontrole glukoze.
English: • Do not split, chew or crush the tablets.
Croatian: Nemojte lomiti, žvakati ili drobiti tablete.
English: Among post marketing reports, while not all cases were confounded by risk factors, many patients had factors which are known to be associated with pancreatitis such as increased triglycerides (see section 4.4), gallstones, and alcohol consumption.
Croatian: U prijavama nakon stavljanja lijeka u promet, iako nisu svi slučajevi bili povezani s faktorima rizika, mnogi bolesnici su imali faktore za koje se zna da su povezani s pankreatitisom, kao što su povišeni trigliceridi (vidjeti dio
English: If you are pregnant or breast feeding, think you may be pregnant or planning to have a baby ask your doctor for advice before taking Seroquel XR.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratit se svom liječniku za savjet prije nego uzmete Seroquel XR.
English: Paediatric Population:
Croatian: Pedijatrijska populacija:
English: What you need to know before you take Seroquel XR
Croatian: Što morate znati prije nego počnete uzimati Seroquel XR
English: What Seroquel contains
Croatian: Što Seroquel sadrži
English: Table 2 ADRs in children and adolescents associated with quetiapine therapy that occur in a higher frequency than adults, or not identified in the adult population
Croatian: Tablica 2 Nuspojave u djece i adolescenata povezane s liječenjem kvetiapinom koje se javljaju s većom učestalošću nego u odraslih ili koje nisu zabilježene u odrasloj populaciji
English: NAME OF THE MARKETING AUTHORISATION HOLDER AstraZeneca
Croatian: ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET AstraZeneca
English: Pharmacokinetic data were sampled in 9 children aged 10-12 years old and 12 adolescents, who were on steady-state treatment with 400 mg quetiapine (Seroquel) twice daily.
Croatian: Farmakokinetički podaci dobiveni su na uzorku od devetero djece u dobi od 10-12 godina i 12 adolescenata, koji su bili u stanju dinamičke ravnoteže s 400 mg kvetiapina (Seroquel) dva puta dnevno.
English: The pharmacokinetics of quetiapine and norquetiapine are linear across the approved dosing range.
Croatian: Farmakokinetika kvetiapina i norkvetiapina je linearna unutar odobrenog raspona doza.
English: On the basis of this, concomitant use of quetiapine with CYP3A4inhibitors is contraindicated.
Croatian: Na osnovi toga, kontraindicirana je istodobna uporaba kvetiapina s CYP3A4 inhibitorima.
English: A placebo-controlled trial evaluating fixed doses of quetiapine across the range of 75 to 750 mg/day showed no evidence of an increase in EPS or the use of concomitant anticholinergics.
Croatian: U placebom kontroliranom ispitivanju s fiksnim dozama kvetiapina (u rasponu od 75 do 750 mg dnevno), nije se pokazalo povećanje EPS-a kao niti potreba za istodobnom primjenom antikolinergika.
English: PHARMACEUTICAL FORM AND CONTENTS 10 prolonged-release tablets
Croatian: OBLIK I SADRŽAJ 10 tableta s produljenim oslobađanjem
English: Based on public literature, patients with delerium and agitation and a clear anticholinergic syndrome may be treated with physostigmine, 1-2 mg (under continuous ECG monitoring).
Croatian: Na temelju objavljene literature, bolesnici s delirijem i agitacijom, koji imaju jasan antikolinergički sindrom, mogu biti liječeni fizostigminom, 1-2 mg (pod kontinuiranim praćenje EKG-a).
English: Quetiapine produces only weak catalepsy at effective dopamine D2-receptor blocking doses.
Croatian: Kvetiapin izaziva samo blagu katalepsiju u dozama koje učinkovito blokiraju dopaminske D2 receptore.
English: As with other antipsychotics, caution is recommended when treating patients with a history of seizures (see Section 4.8).
Croatian: Kao i kad je riječ o ostalim antipsihoticima, preporučuje se oprez u liječenju bolesnika s anamnezom napadaja (vidjeti dio 4.8).
English: There was no apparent dose relationship.
Croatian: Nije bilo vidljive povezanosti s primijenjenom dozom kvetiapina.
English: Dose reduction or more gradual titration should be considered if orthostatic hypotension occurs, especially in patients with underlying cardiovascular disease.
Croatian: Ako dođe do ortostatske hipotenzije, potrebno je razmotriti smanjenje doze ili postupnije titriranje doze, osobito u bolesnika s podležećom kardiovaskularnom bolešću.
English: This increase in clearance reduced systemic quetiapine exposure (as measured by AUC) to an average of 13% of the exposure during administration of quetiapine alone; although a greater effect was seen in some patients.
Croatian: Ovo povećanje klirensa smanjilo je sustavnu izloženost kvetiapinu (određenu preko AUC-a) i to na prosječno 13% izloženosti tijekom primjene samog kvetiapina; premda je kod nekih bolesnika ovaj učinak bio još izraženiji.
English: 6 film-coated tablets 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 60 film-coated tablets 100 film-coated tablets
Croatian: 6 filmom obloženih tableta 20 filmom obloženih tableta 30 filmom obloženih tableta 50 filmom obloženih tableta 60 filmom obloženih tableta 100 filmom obloženih tableta
English: In clinical trials, no additional benefit was seen in the 600 mg group compared to the 300 mg group (see section 5.1).
Croatian: Tijekom kliničkih ispitivanja nije zabilježena dodatna korist u skupini koja je primala dozu od 600 mg u odnosu na skupinu koja je primala dozu od 300 mg (vidjeti dio
English: • Increased blood creatine phosphokinase (a substance from the muscles
Croatian: • povećana razina kreatin fosfokinaze u krvi (tvari iz mišića)
English: Pancreatitis has been reported in clinical trials and during post marketing experience.
Croatian: Pankreatitis je bio prijavljen u kliničkim ispitivanjima te nakon stavljanja lijeka u promet.
English: In an embryofetal toxicity study in rabbits the foetal incidence of carpal/tarsal flexure was increased.
Croatian: U ispitivanju embriofetalne toksičnosti kod kunića fetalna incidencija karpalne/tarzalne fleksure je bila povećana.
English: When Seroquel XR is compared to Seroquel immediate release, the norquetiapine metabolite AUC is 18% lower.
Croatian: Seroquel XR i Seroquel tablete, AUC metabolita norkvetiapina je 18% niža.
English: Incidence of patients who have a QTc shift from <450 msec to ≥450 msec with a ≥30 msec increase.
Croatian: Incidencija bolesnika koji imaju QT pomak od < 450 milisekundi do ≥ 450 milisekundi s povećanjem od ≥ 30
English: Lipid changes should be managed as clinically appropriate.
Croatian: Promjene u razini lipida potrebno je liječiti u skladu s kliničkom praksom.
English: The mean quetiapine plasma clearance decreases with approximately 25% in persons with known hepatic impairment (stable alcoholcirrhosis).
Croatian: Srednja vrijednost klirensa kvetiapina u plazmi smanjuje za otprilike 25% u osoba s poznatim oštećenjem funkcije jetre (stabilna ciroza jetre uzrokovana alkoholom).
English: For the treatment of schizophrenia and moderate to severe manic episodes in bipolar disorder Seroquel XR should be administrated at least one hour before a meal.
Croatian: Za liječenje shizofrenije i umjerenih do teških maničnih epizoda u bipolarnom poremećaju Seroquel XR potrebno je uzimati najmanje jedan sat prije obroka.
English: The available evidence from placebo-controlled clinical trials is presented in sections 4.4, 4.8, 5.1 and 5.2.
Croatian: Podaci dostupni iz placebom kontroliranih kliničkih ispitivanja su prikazani u dijelovima 4.4, 4.8, 5.1 i 5.2. Oštećenje funkcije bubrega:
English: • Increased levels of sugar in the blood.
Croatian: • povišenje razine šećera u krvi
English: There was no difference in magnitude of effect between the patients who received 300 mg Seroquel IR and those who received 600 mg dose.
Croatian: Nije bilo razlike u veličini učinka između bolesnika koji su dobivali 300 mg Seroquela s trenutnim oslobađanjem u usporedbi s onima kojima su davane doze od 600 mg.
English: If you take more Seroquel XR than you should
Croatian: Ako uzmete više Seroquela XR nego što ste trebali
English: Steady-state peak molar concentrations of the active metabolite norquetiapine are 35% of that observed for quetiapine.
Croatian: Vršne molarne koncentracije aktivnog metabolita norkvetiapina u stanju dinamičke ravnoteže iznose 35% od onih opaženih za kvetiapin.
English: Co-administration of quetiapine and phenytoin (another microsomal enzyme inducer) caused a greatly increased clearance of quetiapine by approx. 450%.
Croatian: Istodobnim uzimanjem kvetiapina i fenitoina (drugog induktora mikrosomskih enzima) značajno se povećao klirens kvetiapina za približno 450%.