FrancophonIA/ELRC3.0 huggingface dataset:
English: Swelling or pain in the groin or the arm, back pain, bruising, headache, coughing blood, pink or red urine, sweating, feeling faint or sick or dizzy due to low blood pressure may be signs of internal bleeding.
Croatian: Oticanje ili bol u preponama ili u ruci, leđima, nastanak modrica, glavobolja, iskašljavanje krvi, ružičasti ili crveni urin, znojenje, osjećaj nesvjestice ili mučnine ili vrtoglavice zbog niskog tlaka krvi mogu biti znaci unutarnjeg krvarenja.
English: - if you have severe kidney problems or if you need kidney dialysis.
Croatian: - ako imate teških problema s bubrezima ili Vam je potrebna dijaliza bubrega.
English: Pharmacotherapeutic group: antithrombotic agents, Direct thrombin inhibitors, ATC code: B01AE06.
Croatian: Farmakoterapijska skupina: Antitrombotici, izravni inhibitori trombina, ATK oznaka: B01AE06.
English: Thrombotic (9/110, 8.2%) and major bleeding events (2/110, 1.8%) were observed in the study.
Croatian: U ispitivanju su zabilježeni trombotički događaji (9/110; 8,2%) i velika krvarenja (2/110: 1,8%).
English: The analysis and results for the HORIZONS trial at 30 days for the overall (ITT) population is shown in Table 2.Results at 1 year were consistent with results at 30 days.
Croatian: Analiza i rezultati 30-dnevnog ispitivanja HORIZONS za cjelokupnu (ITT) populaciju prikazani su u tablici 2. Rezultati za 1 godinu bili su sukladni s rezultatima za 30 dana.
English: You can also report side effects directly via the national reporting system listed in Appendix V.
Croatian: Nuspojave možete prijaviti izravno putem nacionalnog sustava za prijavu nuspojava navedenog u Dodatku V.
English: Very common side effects (may affect more than 1 in 10 people): • Minor bleeding
Croatian: Vrlo česte nuspojave (mogu zahvatiti više od 1 na 10 osoba): • manje krvarenje
English: Acute cardiac events
Croatian: Akutni srčani događaji
English: Thus, bivalirudin initially acts as a complete non-competitive inhibitor of thrombin, but transitions over time to become a competitive inhibitor enabling initially inhibited thrombin molecules to interact with other clotting substrates and to coagulation if required.
Croatian: Stoga bivalirudin početno djeluje kao potpun, nekompetitivni inhibitor trombina, ali vremenom postaje kompetitivni inhibitor omogućavajući početno inhibiranim molekulama trombina i drugim supstratima zgrušavanja da međusobno djeluju i omoguće koagulaciju, ako je to potrebno.
English: The doctor will check the solution and will discard it, if it contains particles or is discoloured.
Croatian: Liječnik će provjeriti otopinu i baciti je ako sadrži čestice ili je promijenila boju.
English: Anaphylaxis, including anaphylactic shock with fatal outcome has been reported very rarely (≤1/10,000) in post-marketing experience (see section 4.8).
Croatian: Anafilaksija, uključujući anafilaktični šok sa smrtonosnim ishodom prijavljena je vrlo rijetko (≤1/10 000) u postmarketinškom ispitivanju (vidjeti dio 4.8).
English: Mortality among these patients was nil.
Croatian: Nije bilo smrtnosti u ovih bolesnika.
English: For instructions for monitoring acute stent thrombosis, see section 4.4. d. Section 4.4 describes precautions for INR monitoring when bivalirudin is co-administered with warfarin.
Croatian: Za upute o nadzoru akutne tromboze stenta pogledajte dio 4.4. d. Dio 4.4 opisuje mjere opreza za nadzor INR kada se bivalirudin primjenjuje istovremeno s varfarinom.
English: WHAT YOU NEED TO KNOW BEFORE YOU USE ANGIOX
Croatian: ŠTO MORATE ZNATI PRIJE NEGO POČNETE PRIMJENJIVATI ANGIOX
English: Occasionally, reactions can be more severe with throat itching, throat tightening, swelling of the eyes, face, tongue or lips, high pitched whistling during inhaling (stridor), difficulty breathing or exhaling (wheezes).
Croatian: Povremeno reakcije mogu biti teže i uključuju svrbež u grlu, stezanje u grlu, oticanje očiju, lica, jezika ili usana, visokofrekventni zviždeći zvuk pri udisanju (stridor), otežano disanje ili izdisanje (piskanje).
English: Angiox is available in packs of 10 vials.
Croatian: Angiox je dostupan u pakiranjima od 10 bočica.
English: - After reconstitution (addition of 5 ml water for injections to the vial to dissolve the powder),
Croatian: - Nakon pripreme otopine (dodavanje 5 ml vode za injekcije bočici kako bi se otopio prašak),
English: Do not administer intramuscularly.
Croatian: Ne primjenjivati intramuskularno.
English: Pharmacokinetic studies indicate that hepatic metabolism of bivalirudin is limited, therefore the safety and efficacy of bivalirudin have not been specifically studied in patients with hepatic impairment.
Croatian: Farmakokinetička ispitivanja pokazala su da je metabolizam bivalirudina kroz jetru ograničen, stoga sigurnost i djelotvornost bivalirudin nisu posebno proučavani u bolesnika s oštećenjem jetre.
English: Detailed information on this medicinal product is available on the web site of the European Medicines Agency http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu.
English: Two deaths occurred after acute stent thrombosis, 1 in each arm of the study.
Croatian: Došlo je do dva smrtna događaja nakon akutne tromboze stenta, po jedan u svakoj grupi ispitanika.
English: Table 9 summarises compatible and incompatible concentrations of these compounds.
Croatian: Tablica 9 prikazuje sažetak kompatibilnih i nekompatibilnih koncentracija tih spojeva.
English: Do not use this medicine after the expiry date which is stated on the label and carton after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici i kutiji iza oznake EXP/“Rok valjanosti“.
English: Use with other anticoagulant therapy
Croatian: Primjena s drugom antikoagulantom terapijom
English: The educational materials will be used in all member states for both initial training and re-education in the event of reports of bolus only dosing without subsequent infusion.
Croatian: Obrazovni materijal koristit će se u svim zemljama članicama za početnu obuku i ponovno obrazovanje u slučajevima ako se prijavi da je doziranje vršeno samo primjenom bolusa kojeg nije slijedila infuzija.
English: Combined use of anti-coagulant medicinal products can be expected to increase the risk of bleeding (see section 4.5).
Croatian: Može se očekivati da kombinirana primjena antikoagulansa povećava opasnost od krvarenja (vidjeti dio 4.5).
English: • The most frequent serious and fatal adverse reactions are major haemorrhage (access site and non access-site bleeding, including intracranial haemorrhage) and hypersensitivity, including anaphylactic shock.
Croatian: • Najčešće ozbiljne i smrtonosne nuspojave su veliko krvarenje (krvarenje na pristupnom mjestu i krvarenje koje nije na pristupnom mjestu, uključujući intrakranijalno krvarenje) i preosjetljivost uključujući anafilaktički šok.
English: Patients should remain for at least 24 hours in a facility capable of managing ischaemic complications and should be carefully monitored following primary PCI for signs and symptoms consistent with myocardial ischaemia.
Croatian: Bolesnici trebaju ostati barem 24 sata u ustanovi koja opremljena za liječenje ishemijskih komplikacija i trebaju biti pažljivo monitorirani nakon primarnog PCI-ja radi znakova i simptoma ishemije miokarda.
English: • Brief information on preparation and administration instructions.
Croatian: • Sažete informacije o pripremi i informacije o primjeni.
English: The intravenous infusion may continue at this dose for up to 4 hours after the PCI and for STEMI patients (those with a severe type of heart attack) it should continue at this dose for up to 4 hours.
Croatian: Infuzija u venu se može nastaviti tom dozom do 4 sata nakon PCI-ja i u bolesnika sa STEMI-jem (u onih s teškim oblikom srčanog udara) treba nastaviti tom dozom do 4 sata.
English: If you have kidney problems, the dose of Angiox may need to be reduced.
Croatian: Ako imate probleme s bubrezima, doza Angioxa bi trebala biti smanjena.
English: Rarely this may require surgery to repair the blood vessel in the groin (fistula, pseudoaneurysm) (may affect up to 1 in 1,000 people).
Croatian: To može, u rijetkim situacijama, iziskivati kirurški zahvat kako bi se popravile krvne žile u preponama (fistula, pseudoaneurizma) (mogu zahvatiti do 1 na 1000 osoba).
English: In a clinical trial of 110 paediatric patients (neonates to <16 years of age) undergoing percutaneous intravascular procedures, the safety, pharmacokinetic and pharmacodynamic profile of bivalirudin was evaluated [TMC-BIV-07-01].
Croatian: U kliničkom ispitivanju provedenom na 110 pedijatrijskih bolesnika (od novorođenčadi do <16 godina starosti) podvrgnutih perkutanim intravaskularnim postupcima, procijenjen je sigurnosni, farmakokinetički i farmakodinamički profil bivalirudina [TMC-BIV-07-01].
English: What Angiox is and what it is used for What you need to know before you use Angiox
Croatian: Što je Angiox i za što se koristi Što morate znati prije nego počnete primjenjivati Angiox Kako primjenjivati Angiox
English: Angiox should be administered with acetylsalicylic acid and clopidogrel.
Croatian: Angiox treba primijeniti s acetilsalicilatnom kiselinom i klopidogrelom.
English: Clearance is reduced by approximately 20% in patients with moderate or severe renal impairment, and 80% in dialysis-dependent patients (Table 8).
Croatian: Klirens je smanjen za otprilike 20% u bolesnika s umjerenim ili teškim oštećenjem bubrega i 80% u bolesnika ovisnih o dijalizi (tablica 8).
English: In the case of shock, the current medical standards for shock treatment should be applied.
Croatian: U slučaju pojave šoka treba se primijeniti hitno standardno liječenje šoka.
English: All patients received acetylsalicylic acid and clopidogrel with twice as many patients (approximately 64%) receiving a 600mg loading dose of clopidogrel than a 300mg loading dose of clopidogrel.
Croatian: Svi su bolesnici dobivali acetilsalicilatnu kiselinu i klopidogrel, a dvostruko je više bolesnika (otprilike 64%) dobivalo udarnu dozu klopidogrela od 600 mg nego udarnu dozu klopidogrela od 300 mg.
English: • a known hypersensitivity to the active substance or to any of the excipients listed in section 6.1,
Croatian: • poznatom preosjetljivošću na djelatnu tvar ili bilo koju od pomoćnih tvari navedenih u dijelu
English: Hypersensitivity, including anaphylactic reaction and shock, including reports with fatal outcome
Croatian: Poremećaji imunološkog sustava preosjetljivost, uključujući anafilaktičku reakciju i šok, uključujući prijave o smrtnom ishodu
English: In the event of major bleeding, treatment with bivalirudin should be immediately discontinued.
Croatian: Ako se pojavi veliko krvarenje, liječenje bivalirudinom treba odmah prekinuti.
English: • Haematoma (bruising)
Croatian: • hematom (nastanak modrica)
English: A population pharmacokinetic/pharmacodynamic analysis, and an Exposure and Adverse Event Assessment Model based on the data from this study determined that in paediatric patients, use of the adult dosing with plasma levels similar to that achieved in adults was associated with lower levels of thrombotic events with no impact on bleeding events (see section 4.2).
Croatian: Farmakokinetička/farmakodinamička analiza populacije te model za procjenu izloženosti i štetnih događaja na temelju podataka iz navedenog ispitivanja utvrdili su da je primjena doze za odrasle u pedijatrijskih bolesnika s razinama u plazmi sličnima onima koje se postižu u odraslih bila povezana s nižim razinama trombotičkih događaja bez utjecaja na epizode krvarenja (vidjeti dio 4.2).
English: • if bleeding occurs (if this happens, treatment with Angiox will be stopped).
Croatian: • ako dođe do krvarenja (u slučaju krvarenja liječenje Angioxom se mora prekinuti).
English: Where insufficient ACT increase is observed, the possibility of medication error should be considered, for example inadequate mixing of Angiox or intravenous equipment failures.
Croatian: Kada se uoči nedostatan porast ACT-a, treba uzeti u obzir mogućnost medikacijske pogreške poput primjerice neodgovarajućeg miješanja lijeka Angiox ili kvarova na intravenskoj infuzijskoj opremi.
English: Patients in Arms A and B were also randomised to receive a GP IIb/IIIa inhibitor either upfront at the time of randomization (prior to angiography) or at the time of PCI.
Croatian: Bolesnici u okviru grupa A i B također su bili randomizirani na primjenu inhibitora GP IIb/IIIa; ili unaprijed u vrijeme randomizacije (prije angiografije) ili u vrijeme PCI-ja.
English: ACT values 5 minutes after bivalirudin bolus average 365 +/- 100 seconds.
Croatian: ACT vrijednosti nakon 5 minuta bolusa bivalirudina prosječno su 365 +/- 100 sekundi.
English: The ACT value is positively correlated with the dose and plasma concentration of bivalirudin administered.
Croatian: ACT vrijednost je u pozitivnoj korelaciji s dozom i koncentracijom primijenjenog bivalirudina u plazmi.
English: Uncommonly (may affect up to 1 in 100 people) the number of blood platelets may be low which can worsen any bleeding.
Croatian: Manje često (mogu zahvatiti do 1 na 100 osoba) broj trombocita može biti nizak što može pogoršati krvarenje.
English: The pharmacokinetics of bivalirudin have not been studied in patients with hepatic impairment but are not expected to be altered because bivalirudin is not metabolized by liver enzymes such as cytochrome P-450 isozymes.
Croatian: Farmakokinetika bivalirudina nije bila ispitivana u bolesnika s poremećajem jetre, ali se ne očekuje da bude promijenjena jer se bivalirudin ne metabolizira jetrenim enzimima kao što su izoenzimi citokroma P-450.
English: Prolonged post PCI infusions of bivalirudin at recommended doses have not been associated with an increased rate of bleeding (see section 4.2).
Croatian: Produžene infuzije bivalirudina nakon PCI-ja u preporučenim dozama nisu povezane s povišenom stopom krvarenja (vidjeti dio 4.2).
English: o while you are in hospital: tell the doctor or nurse immediatelyo after you've left hospital: contact your doctor directly or go immediately to the Emergency
Croatian: o dok ste u bolnici: odmah recite liječniku ili medicinskoj sestrio nakon što napustite bolnicu: obratite se izravno svom liječniku ili otiđite do odjela Hitne službe u Vama najbližoj bolnici
English: Administration errors may lead to fatal thrombosis.
Croatian: Pogreške prilikom primjene lijeka mogu uzrokovati smrtonosnu trombozu.
English: Angiox can be used in conjunction with a GP IIb/IIIa inhibitor.
Croatian: Angiox se može koristiti zajedno s inhibitorima GP IIb/IIIa.
English: Unexplained decreases in haematocrit, haemoglobin or blood pressure may indicate haemorrhage.
Croatian: Neobjašnjena smanjenja hematokrita, hemoglobina ili krvnog tlaka mogu ukazati na krvarenje.
English: Angiox should be administered by a physician experienced in either acute coronary care or in coronary intervention procedures.
Croatian: Angiox treba primijeniti liječnik s iskustvom u akutnoj koronarnoj skrbi ili u postupcima koronarne intervencije.
English: The pharmacodynamic effects of bivalirudin may be assessed using measures of anticoagulation including the ACT.
Croatian: Farmakodinamički učinak bivalirudina može se procijeniti mjerama za antikoagulantnu aktivnost uključujući i ACT.
English: The systemic clearance of bivalirudin decreases with glomerular filtration rate (GFR).
Croatian: Sistemski klirens bivalirudina smanjuje se s brzinom glomerularne filtracije (GFR).
English: There are no or limited data from the use of bivalirudin in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni bivalirudina u trudnica ograničeni.
English: Store in a refrigerator (2C-8C).
Croatian: Čuvati u hladnjaku (2 °C- °8 °C).
English: TIMI major bleeding was defined as intracranial bleeding or a decrease in haemoglobin concentration ≥5 g/dl.
Croatian: Veliko krvarenje TIMI definirano je kao intrakranijalno krvarenje ili smanjenje koncentracije hemoglobina od ≥5 g/dl.
English: The primary analysis and results for ACUITY at 30-days and 1 year for the overall (ITT) population and for the patients that received acetylsalicylic acid and clopidogrel as per protocol (pre-angiography or pre-PCI) are shown in Tables 3 and 4.
Croatian: Primarna analiza i rezultati ACUITY za 30 dana i 1 godinu sveukupne populacije (ITT) te bolesnike koji su primali acetilsalicilatnu kiselinu i klopidogrel prema planu ispitivanja (prije angiografije ili prije PCI-ja) prikazani su u tablicama 3 i 4.
English: Based on the short half-life of bivalirudin (25 minutes), failure to initiate an infusion following the Angiox bolus will result in a plasma concentration that is below the required level within minutes
Croatian: S obzirom na kratki poluvijek bivalirudina (25 minuta), propust da se započne infuzija nakon bolusa (doze) Angioxa rezultirat će time da unutar par minuta koncentracija u plazmi bude ispod potrebne razine.
English: Thrombin plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently crosslinked framework that stabilises the thrombus.
Croatian: Trombin ima središnju ulogu u trombotičkom procesu, djelujući na cijepanje fibrinogena na monomere fibrina i aktivirajući faktor XIII do faktora XIIIa, čime fibrin razvija kovalentno umreženu okosnicu koja stabilizira tromb.
English: Pharmacokinetics have been evaluated in elderly patients as part of a renal pharmacokinetic study.
Croatian: Farmakokinetika starijih bolesnika procijenjena je kao dio ispitivanja bubrežne farmakokinetike.
English: For patients with acute coronary syndromes (ACS) who are treated medically the recommended starting dose is:
Croatian: Za bolesnike s akutnim koronarnim sindromom (ACS) koji primaju lijekove za svoje stanje preporučena početna doza je:
English: In cases of overdose, treatment with bivalirudin should be immediately discontinued and the patient monitored closely for signs of bleeding.
Croatian: U slučajevima predoziranja liječenje bivalirudinom treba odmah prekinuti te pažljivo nadzirati bolesnika radi znakova krvarenja.
English: Add 5 ml sterile water for injections to one vial of Angiox and swirl gently until completely dissolved and the solution is clear.
Croatian: Dodajte 5 ml sterilne vode za injekcije u jednu bočicu Angioxa i nježno je vrtite dok se potpuno ne otopi i otopina postane bistra.
English: The HORIZONS trial was a prospective, dual arm, single blind, randomised, multi-centre trial to establish the safety and efficacy of bivalirudin in patients with STEMI undergoing a primary PCI strategy with stent implantation with either a slow release paclitaxel-eluding stent (TAXUS™) or an otherwise identical uncoated bare metal stent (Express2™).
Croatian: Ispitivanje HORIZONS bilo je prospektivno, jednostruko slijepo, randomizirano, multicentrično ispitivanje u dvije grupe ispitanika, u svrhu utvrđivanja sigurnosti i djelotvornosti bivalirudina u bolesnika sa STEMI-em u kojih se primjenjuje strategija primarnog PCI-ja ugrađivanjem stenta s polagano otpuštajućim paklitakselom (TAXUS™) ili identičnim metalnim stentom bez lijeka (Express2™).
English: A total of 356 (7.7%) of patients randomised to Arm C also received a GP IIb/IIIa inhibitor.
Croatian: Ukupno 356 (7,7%) bolesnika randomizirano u grupu C također je dobivalo inhibitor GP IIb/IIIa.
English: 30-day Composite ischaemia
Croatian: 30 dana Kompozitna ishemija
English: Thrombin also activates Factors V and VIII, promoting further thrombin generation, and activates platelets, stimulating aggregation and granule release.
Croatian: Trombin također aktivira faktor V i VIII pospješujući daljnje stvaranje trombina te aktivira krvne pločice, stimulira agregaciju i otpuštanje granula.
English: Angiox contains a substance called bivalirudin which is an antithrombotic medicine.
Croatian: Angiox sadrži tvar naziva bivalirudin koja je antitrombotski lijek.
English: Pharmacokinetic parameters for bivalirudin in patients with normal and impaired
Croatian: Farmakokinetički parametri za bivalirudin u bolesnika s normalnom i oštećenom bubrežnom funkcijom
English: Angiox is supplied as a lyophilised powder in 10 ml single use glass vials (Type 1) closed with a butyl rubber stopper and sealed with a crimped aluminum seal.
Croatian: Angiox se isporučuje kao liofilizirani prašak u staklenim (tip 1) bočicama od 10 ml za jednokratnu uporabu, zatvorenima čepom od butilne gume koji je ovijen aluminijskim prstenom.
English: In clinical studies bivalirudin has been shown to provide adequate anticoagulation during PCI procedures.
Croatian: Klinička su ispitivanja pokazala da bivalirudin omogućava adekvatnu antikoagulaciju tijekom PCI procedura.
English: The other ingredients are mannitol and sodium hydroxide 2% (for pH adjustment)
Croatian: Drugi sastojci su manitol i natrijev hidroksid 2% (za podešavanje pH)
English: (For full information on posology see section 4.2 of SmPC)
Croatian: (Za potpune informacije o doziranju vidjeti dio 4.2 Sažetka opisa svojstava lijeka)
English: Mannitol, sodium hydroxide 2%
Croatian: manitol, 2% natrijev hidroksid
English: Unplanned revasc.
Croatian: Neplanirana revaskularizacija
English: The primary metabolite resulting from the cleavage of Arg3-Pro4 bond of the Nterminal sequence by thrombin is not active because of the loss of affinity to the catalytic active site of thrombin.
Croatian: Primarni metabolit, koji proizlazi iz cijepanja veze Arg3-Pro4 na N-terminalnom kraju sekvence trombinom, nije aktivan zbog gubitka afiniteta za katalitički aktivno mjesto na trombinu.
English: Once the ACT value is greater than 225 seconds, no further monitoring is required provided the 1.75 mg/kg/h infusion dose is properly administered.
Croatian: Kad je ACT vrijednost veća od 225 sekundi, nije potreban daljnji nadzor, pod uvjetom da je infuzijska doza od 1,75 mg/kg/sat ispravno primijenjena.
English: Patients with renal impairment should be carefully monitored for clinical signs of bleeding during PCI, as clearance of bivalirudin is reduced in these patients (see section 5.2)
Croatian: Bolesnike s oštećenjem bubrega treba pomno nadzirati na pojavu kliničkih znakova krvarenja tijekom PCI postupka jer je klirens bivalirudina u tih bolesnika smanjen (vidjeti dio 5.2).
English: Healthcare providers are recommended to refer to the Angiox Summary of Product Characteristics for full information on dosing.
Croatian: Zdravstvenim djelatnicima preporučuje se pročitati sažetak opisa svojstava lijeka Angiox za potpune informacije o doziranju.
English: This medicine contains less than 23 mg of sodium per vial, which means that it is essentially “sodiumfree”.
Croatian: Lijek sadrži manje od 23 mg natrija po bočici što znači da u biti "ne sadrži natrij".
English: Thrombosis includes coronary artery thrombosis (blood clot in the heart arteries or within a stent being felt as a heart attack which can also be fatal) and/or thrombosis in the catheter, both of which are rare (may affect up
Croatian: Tromboza uključuje trombozu koronarnih arterija (krvni ugrušak u srčanim arterijama ili unutar stenta što se osjeća kao srčani udar koji također može biti smrtonosan) i/ili trombozu u kateteru, a obje se javljaju rijetko (mogu zahvatiti do 1 na 1000 osoba).
English: Cases of overdose of up to 10 times the recommended dose have been reported in clinical trials.
Croatian: U kliničkim ispitivanjima bilo je prijavljeno predoziranje u iznosu do 10 puta od preporučene doze.
English: Adverse reactions for bivalirudin from HORIZONS, ACUITY, REPLACE-2 trials and post-marketing experience
Croatian: Nuspojave bivalirudina iz ispitivanja HORIZONS, ACUITY, REPLACE-2 i postmarketinškog iskustva
English: Major bleeding rates are shown in Table 6 for the IIT population and Table 7 for the per protocol population (patients receiving clopidogrel and acetylsalicylic acid).
Croatian: Stope većih krvarenja prikazane su u tablici 6 za ITT («intention to treat») populaciju i u tablici 7 za bolesnike prema planu ispitivanja (bolesnici koji su dobivali klopidogrel i acetilsalicilatnu kiselinu).