FrancophonIA/ELRC3.0 huggingface dataset:
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/.
English: Pramipexole was not genotoxic.
Slovenian: Pramipeksol ni bil genotoksičen.
English: The three strips are marked with "Week 1", "Week 2" and "Week 3".
Slovenian: Pretisni omoti so označeni s "1. teden", "2. teden" in "3. teden.
English: The frequency category is probably not greater than "uncommon".
Slovenian: Njihova kategorija pogostnosti verjetno ni višja od kategorije "občasni".
English: The increase in Cmax is not considered clinically relevant.
Slovenian: Povečanje Cmax ne velja za klinično pomembno.
English: This is to avoid postural hypotension (a fall in blood pressure on standing up).
Slovenian: To je potrebno, da bi se izognili posturalni hipotenziji (padcu krvnega tlaka pri vstajanju).
English: Parkinson's disease
Slovenian: Parkinsonovo boleznijo.
English: Patients should be informed about this before tapering the dopamine agonist, and monitored regularly thereafter.
Slovenian: Bolnike je treba o tem obvestiti pred začetkom zmanjševanja odmerka dopaminskega agonista, nato pa jih je treba redno spremljati.
English: Common (≥1/100 to
Slovenian: Pogosti (≥1/100 do
English: Pharmacotherapeutic group: anti-Parkinson drugs, dopamine agonists, ATC code: N04BC05.
Slovenian: Farmakoterapevtska skupina: antiparkinsoniki, agonisti dopamina, oznaka ATC: N04BC05.
English: This includes medicines, herbal remedies, health foods or supplements that you have obtained without a prescription.
Slovenian: To velja tudi za zdravila rastlinskega izvora, biohrano ali prehranska dopolnila, ki ste jih dobili brez recepta.
English: Lowest maintenance dose Highest maintenance dose
Slovenian: Najmanjši vzdrževalni odmerek Največji vzdrževalni odmerek
English: A decreased body weight by 30 kg results in an increase in Cmax of 45%.
Slovenian: Če se telesna masa zmanjša za 30 kg, se Cmax poveča za 45 %.
English: This finding is not clinically relevant to man.
Slovenian: Ta ugotovitev ni klinično pomembna za ljudi.
English: Do not take Oprymea: - if you are allergic to pramipexole or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Oprymea: - če ste alergični na pramipeksol ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: In case of severe cardiovascular disease, care should be taken.
Slovenian: V primeru hudih kardiovaskularnih obolenj moramo biti previdni.
English: The absolute bioavailability is greater than 90% and the maximum plasma concentrations occur between 1 and 3 hours.
Slovenian: Absolutna biološka uporabnost znaša več kot 90 %, najvišja plazemska koncentracija pa je dosežena v eni do treh urah.
English: If patients report such an observation, the physician should reassess patient's response to therapy.
Slovenian: Če bolniki poročajo o takšnem opažanju, mora zdravnik ponovno oceniti bolnikov odziv na zdravljenje.
English: The tablet can be divided into equal doses.
Slovenian: Tableta se lahko deli na enaka odmerka.
English: The tablets may be taken either with or without food and should be taken each day at about the same time.
Slovenian: Tablete lahko jemljejo s hrano ali brez nje, treba pa jih je jemati vsak dan ob približno isti uri.
English: Hallucinations or somnolence can occur.
Slovenian: Pojavijo se lahko halucinacije in zaspanost.
English: Total exposure (AUC) was not affected by concomitant food intake.
Slovenian: Celotna izpostavljenost (AUC) ob sočasnem jemanju hrane ni bila spremenjena.
English: What Oprymea is and what it is used for
Slovenian: Kaj je zdravilo Oprymea in za kaj ga uporabljamo
English: The effect of Oprymea on the unborn child is not known.
Slovenian: Učinek zdravila Oprymea na nerojenega otroka ni znan.
English: - Altered or increased sexual interest and behaviour of significant concern to you or to others, for example, an increased sexual drive.
Slovenian: - spremenjeno ali povečano spolno zanimanje in vedenje, ki vam ali drugim povzroča znatno zaskrbljenost, na primer povečan libido;
English: Patients who have experienced somnolence and/or an episode of sudden sleep onset must refrain from driving or operating machines.
Slovenian: Bolniki, pri katerih se je že pojavila zaspanost in/ali nenadna epizoda spanja, ne smejo voziti ali upravljati strojev.
English: Uncommon (≥1/1,000 to
Slovenian: Občasni (≥1/1.000 do
English: In rats, the concentration of active substance-related radioactivity was higher in breast milk than in plasma.
Slovenian: Pri podganah je bila koncentracija radioaktivno označene zdravilne učinkovine večja v mleku kot v plazmi.
English: Other medicines and Oprymea
Slovenian: Druga zdravila in zdravilo Oprymea
English: Patients should be informed that (mostly visual) hallucinations can occur.
Slovenian: Bolnikom moramo povedati, da lahko pride do halucinacij (večinoma vidnih).
English: The latter finding was not observed in pigmented rats, nor in a 2-year albino mouse carcinogenicity study or in any other species investigated.
Slovenian: Zadnje ugotovitve niso opazili niti pri pigmentiranih podganah niti v raziskavi kancerogenosti pri 2letnih albino miših ali katerikoli drugi raziskovani vrsti.
English: Patients with kidney disease If you have severe kidney disease, Oprymea may not be a suitable treatment for you.
Slovenian: Bolniki z ledvično boleznijo Če imate hudo ledvično bolezen, zdravilo Oprymea morda za vas ni primerno zdravilo.
English: Maintenance of efficacy was shown in patients treated for 33 weeks.
Slovenian: Pri bolnikih, ki so se zdravili 33 tednov, so pokazali ohranitev učinkovitosti.
English: What you need to know before you take Oprymea
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Oprymea
English: While body weight has no impact on the AUC, it was found to influence the volume of distribution and therefore the peak concentrations Cmax.
Slovenian: Telesna masa ne vpliva na AUC, vpliva pa na volumen porazdelitve in s tem na največjo koncentracijo (Cmax).
English: The potential effects of pramipexole on reproductive function have been investigated in rats and rabbits.
Slovenian: Morebitne učinke pramipeksola na rodila so raziskovali pri podganah in zajcih.
English: If during treatment your kidney problems get worse, you should contact your doctor as soon as possible.
Slovenian: Če se vam bodo ledvične težave med zdravljenjem povečale, se morate čim prej posvetovati z zdravnikom.
English: The Oprymea treatment initiation pack is only to be used for the beginning of the treatment with Oprymea.
Slovenian: Pakiranje za začetno zdravljenje zdravila Oprymea se uporablja samo na začetku zdravljenja z zdravilom Oprymea.
English: Tell your doctor if you experience any of these behaviors; he will discuss ways of managing or reducing the symptoms.
Slovenian: Obvestite svojega zdravnika, če opazite katero od navedenih vedenjskih sprememb; z vami se bo pogovoril o načinih obvladovanja ali zmanjšanja simptomov.
English: - treat the symptoms of moderate to severe primary Restless Legs Syndrome in adults.
Slovenian: - zdravljenje simptomov zmernega do hudega primarnega sindroma nemirnih nog pri odraslih.
English: Nausea and fatigue were more often reported in female patients (20.8% and 10.5%, respectively) compared to males (6.7% and 7.3%, respectively).
Slovenian: O slabosti in utrujenosti so med zdravljenjem s pramipeksolom pogosteje poročali pri ženskah (20,8 % in 10,5 %) kot pri moških (6,7 % in 7,3 %).
English: The tablets should be swallowed whole with water, and must not be chewed, divided or crushed.
Slovenian: Tablete je potrebno pogoltniti cele z vodo in jih ni dovoljeno žvečiti, razdeliti ali zdrobiti.
English: Stimulation of the dopamine receptors triggers nerve impulses in the brain that help to control body movements.
Slovenian: Spodbujanje teh receptorjev sproži v možganih živčne impulze, ki nadzorujejo telesne gibe.
English: Sudden onset of sleep and somnolence
Slovenian: Nenaden nepremagljiv spanec in zaspanost
English: Therefore, interactions with other medicinal products affecting plasma protein binding or elimination by biotransformation are unlikely.
Slovenian: Zato so interakcije z drugimi zdravili, ki bi vplivale na vezavo na plazemske proteine ali na izločanje z biotransformacijo, malo verjetne.
English: Approximately 90% of C-labelled dose is excreted through the kidneys while less than 2% is found in the faeces.
Slovenian: Približno 90 % odmerka, označenega s C, se izloči skozi ledvice, medtem ko v blatu najdemo manj kot 2 % odmerka.
English: Adverse events occurring in at least 5% of patients in the pramipexole group and more common in the pramipexole-treated patients than in patients on placebo were: headache (27.9%, placebo 25.0%), somnolence (7.0%, placebo 5.0%), nausea (18.6%, placebo 10.0%), vomiting (11.6%, placebo 0.0%), upper abdominal pain (7.0%, placebo 5.0%), orthostatic hypotension (9.3%, placebo 5.0%), myalgia (9.3%, placebo 5.0%), sleep disorder (7.0%, placebo 0.0%), dyspnoea (7.0%, placebo 0.0%) and upper respiratory tract infection (7.0%, placebo 5.0%).
Slovenian: Neželeni dogodki, ki so se v skupini s pramipeksolom pojavili pri najmanj 5 % bolnikov, in so bili pri bolnikih, ki so se zdravili s pramipeksolom, pogostejši kot pri placebu, so bili: glavobol (27,9 %, placebo 25,0 %), zaspanost (7,0 %, placebo 5,0 %), siljenje na bruhanje (18,6 %, placebo 10,0 %), bruhanje (11,6 %, placebo 0,0 %), bolečina v zgornjem delu trebuha (7,0 %, placebo 5,0 %), ortostatska hipotenzija (9,3 %, placebo 5,0 %), mialgija (9,3 %, placebo 5,0 %), motnja spanja (7,0 %, placebo 0,0 %), dispneja (7,0 %, placebo 0,0 %) in okužba zgornjih dihalnih poti (7,0 %, placebo 5,0%).
English: Investigations weight decrease including decreased appetite weight increase
Slovenian: Preiskave zmanjšanje telesne mase, vključno z zmanjšanjem apetita povečanje telesne mase
English: Rare: - Mania (agitation, feeling elated or over-excited)
Slovenian: Redki: - manija (agitacija, vznesenost ali prevelika vznemirjenost).
English: If this happens, your doctor may want to change your medication.
Slovenian: Če pride do tega, vam bo zdravnik morda zamenjal zdravilo.
English: There is no pharmacokinetic interaction with selegiline and levodopa.
Slovenian: Farmakokinetičnih interakcij s selegilinom in levodopo ni.
English: The Oprymea treatment initiation pack contains three blister strips of tablets - one strip for each of the first three weeks of your treatment.
Slovenian: Pakiranje za začetno zdravljenje zdravila Oprymea vsebuje tri pretisne omote s tabletami - po en pretisni omot za vsak teden začetnega tritedenskega zdravljenja.
English: Your doctor may need to adjust or stop your dose.
Slovenian: Vaš zdravnik vam bo morda moral prilagoditi odmerek ali zdravilo ukiniti.
English: This leaflet was last revised in.
Slovenian: Navodilo je bilo nazadnje revidirano dne .
English: The total clearance of pramipexole is approximately 500 ml/min and the renal clearance is approximately 400 ml/min.
Slovenian: Skupni očistek pramipeksola je približno 500 ml/min, ledvični očistek pa je približno 400 ml/min.
English: The same study also showed that, at doses of 2 mg/kg (of salt) and higher, pramipexole was associated with retinal degeneration in albino rats.
Slovenian: Ista študija je tudi pokazala, da je bil pramipeksol v odmerkih 2 mg/kg (soli) ali več povezan z degeneracijo mrežnice pri albino podganah.
English: Due to the selection of animal species and the limited parameters investigated, the adverse effects of pramipexole on pregnancy and male fertility have not been fully elucidated.
Slovenian: Zaradi izbire živalskih vrst in omejenih raziskovanih parametrov neželeni učinki pramipeksola na nosečnost in na plodnost samcev niso bili v celoti pojasnjeni.
English: If signs of central nervous system stimulation are present, a neuroleptic agent may be indicated.
Slovenian: Če so prisotni znaki stimulacije osrednjega živčevja, je lahko indicirano nevroleptično zdravilo.
English: Table 1: Parkinson's disease Body System Very common
Slovenian: Preglednica 1: Parkinsonova bolezen Organski sistem
English: The effect on pregnancy and lactation has not been investigated in humans.
Slovenian: Vpliva na nosečnost in dojenje pri človeku niso raziskovali.
English: If you have serious kidney problems, your doctor may need to switch you to a different pramipexole medicine.
Slovenian: Če imate resne ledvične težave, vam bo zdravnik morda zdravilo moral zamenjati z drugo obliko pramipeksola.
English: OUTER BOX (treatment initiation pack containing 3 boxes of 7 prolonged-release tablets)
Slovenian: ZUNANJA ŠKATLA (pakiranje za začetek zdravljenja s 3 škatlami po 7 tablet s podaljšanim sproščanjem)
English: Concomitant administration with food does generally not affect the bioavailability of pramipexole.
Slovenian: Sočasno uživanje hrane večinoma ne vpliva na pramipeksolovo biološko uporabnost.
English: Parts of tablets may occasionally be passed and seen in the stool (faeces) and may look like whole tablets.
Slovenian: Deli tablete se včasih lahko izločijo v blato in izgledajo kot cele tablete.
English: If affected, do not drive or use machines.
Slovenian: Če se pojavijo pri vas, ne vozite in ne upravljajte strojev.
English: With 95 % certainty, the frequency category is not greater than uncommon, but might be lower.
Slovenian: S 95 % gotovostjo se ne pojavlja pogosteje kot občasni neželeni učinki, morda celo redkeje.
English: Do not take a double dose to make up for a forgotten tablet dose.
Slovenian: Ne vzemite dvojnega odmerka, da bi nadomestili pozabljenega.
English: If you do, there is a danger you could overdose, because the medicine may be released into your body too quickly.
Slovenian: Če to storite, je možno, da bo odmerek prevelik, ker se bo zdravilo prehitro sprostilo.
English: Then take your Oprymea prolonged-release tablets next morning and do not take any more Oprymea (immediate release) tablets.
Slovenian: Zdravilo Oprymea tablete s podaljšanim sproščanjem vzemite naslednje jutro, zdravila Oprymea tablete (s takojšnjim sproščanjem) pa ne jemljite več.
English: 20 tablets 30 tablets 60 tablets 90 tablets 100 tablets
Slovenian: 20 tablet 30 tablet 60 tablet 90 tablet 100 tablet
English: Patients already taking Oprymea tablets may be switched to Oprymea prolonged-release tablets overnight, at the same daily dose.
Slovenian: Bolnikom, ki že jemljejo Oprymea tablete, jih lahko čez noč zamenjamo za Oprymea tablete s podaljšanim sproščanjem v enakem dnevnem odmerku.
English: However, in Phase III trials in Parkinson's disease patients no clinically meaningful influence of body weight on the therapeutic effect and tolerability of pramipexole prolonged-release tablets was detected.
Slovenian: Toda v preskušanjih III. faze pri bolnikih s Parkinsonovo boleznijo niso zasledili klinično pomembnega vpliva telesne mase na terapevtski učinek in prenašanje pramipeksol tablet s podaljšanim sproščanjem.
English: However, the potential influence of hepatic insufficiency on Oprymea pharmacokinetics has not been investigated.
Slovenian: Vendar pa potencialnega vpliva jetrne insuficience na farmakokinetiko zdravila Oprymea niso raziskovali.
English: Some patients have reported the occurrence of remnants in faeces which may resemble intact Oprymea prolonged-release tablets.
Slovenian: Nekateri bolniki so poročali o pojavu ostankov v blatu, ki so lahko podobni intaktnim Oprymea tabletam s podaljšanim sproščanjem.
English: Parkinson's disease The daily dose is to be taken divided into 3 equal doses.
Slovenian: Parkinsonova bolezen Dnevni odmerek je treba razdeliti in ga vzeti v 3 enakih odmerkih.
English: Your doctor will then discuss with you if you should continue to take Oprymea.
Slovenian: Zdravnik se bo z vami pogovoril o tem, ali lahko zdravljenje z zdravilom Oprymea nadaljujete.
English: Oprymea should not be used in children or adolescents with Tourette Disorder because of a negative benefit-risk balance for this disorder (see section 5.1).
Slovenian: Zdravila Oprymea ne smemo uporabiti pri otrocih in mladostnikih s Tourettovim sindromom, ker ima pri tej motnji negativno razmerje med koristjo in tveganjem (glejte poglavje 5.1).
English: - Strong impulse to gamble excessively despite serious personal or family consequences.
Slovenian: - močna želja po čezmernem hazardiranju ne glede na posledice za vas ali za družino;
English: In the Phase III studies that established safety and efficacy of pramipexole prolonged-release tablets, patients were instructed to take study medication without regard to food intake.
Slovenian: V preskušanjih III. faze, v katerih so proučevali varnost in učinkovitost pramipeksol tablet s podaljšanim sproščanjem, so bolnikom naročili, naj preskušano zdravilo jemljejo ne glede na obroke hrane.
English: Providing patients do not experience intolerable undesirable effects, the dose should be titrated to achieve a maximal therapeutic effect.
Slovenian: Če bolniki ne trpijo zaradi nevzdržnih neželenih učinkov, odmerek prilagajamo, dokler ne dosežemo maksimalnega terapevtskega učinka.
English: You will need to have your blood pressure checked regularly, especially at the beginning of treatment.
Slovenian: Zlasti na začetku zdravljenja si boste morali redno meriti krvni tlak.
English: If you suffer from Parkinson's disease you should not stop treatment with Oprymea abruptly.
Slovenian: Če imate Parkinsonovo bolezen, zdravljenja z zdravilom Oprymea ne smete nenadoma prekiniti.
English: Biotransformation Pramipexole is metabolised in man only to a small extent.
Slovenian: Biotransformacija Pramipeksol se pri človeku presnavlja le v manjši meri.
English: In early and advanced Parkinson's disease, efficacy of pramipexole in controlled clinical trials was maintained for approximately six months.
Slovenian: Pri bolnikih z zgodnjo in napredovalo Parkinsonovo boleznijo, je bila učinkovitost pramipeksola v kontroliranih kliničnih preskušanjih vzdrževana približno šest mesecev.
English: If renal function declines during maintenance therapy, the recommendations given above should be followed.
Slovenian: Če se ledvično delovanje med zdravljenjem poslabša, je potrebno ravnati po zgornjih priporočilih.
English: In a clinical trial with healthy volunteers, where pramipexole prolonged-release tablets were titrated faster (every 3 days) than recommended up to 3.15 mg pramipexole base (4.5 mg of salt) per day, an increase in blood pressure and heart rate was observed.
Slovenian: V kliničnem preskušanju pri zdravih prostovoljcih, v katerem so odmerke pramipeksola v obliki tablet s podaljšanim sproščanjem povečevali hitreje (vsake 3 dni), kot je priporočeno, in sicer do 3,15 mg pramipeksolijeve baze (4,5 mg soli) na dan, sta se povečala krvni tlak in srčna frekvenca.
English: What Oprymea is and what it is used for What you need to know before you take Oprymea How to take Oprymea
Slovenian: Kaj je zdravilo Oprymea in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Oprymea Kako jemati zdravilo Oprymea Možni neželeni učinki
English: If you suffer from Parkinson's disease, you may experience the following side effects:
Slovenian: Če imate Parkinsonovo bolezen, so možni naslednji neželeni učinki:
English: Oprymea with food, drink and alcohol You should be cautious while drinking alcohol during treatment with Oprymea.
Slovenian: Zdravilo Oprymea skupaj s hrano, pijačo in alkoholom Če med zdravljenjem z zdravilom Oprymea pijete alkohol, morate biti previdni.
English: In humans, the protein binding of pramipexole is very low (< 20%) and the volume of distribution is large (400 l).
Slovenian: Pri človeku je vezava pramipeksola na beljakovine zelo majhna (< 20 %), volumen porazdelitve pa je velik (400 l).
English: If they occur, the dose of levodopa should be decreased.
Slovenian: Če se to zgodi, zmanjšamo odmerek levodope.
English: The elimination half-life (t½) varies from 8 hours in the young to 12 hours in the elderly.
Slovenian: Razpolovni čas (t1/2) izločanja se giblje od 8 ur pri mladih do 12 ur pri starejših ljudeh.
English: It is recommended to monitor blood pressure, especially at the beginning of treatment, due to the general risk of postural hypotension associated with dopaminergic therapy.
Slovenian: Priporočljivo je spremljati krvni tlak, zlasti na začetku zdravljenja, saj je z dopaminergičnim zdravljenjem povezano splošno tveganje za posturalno hipotenzijo.
English: Sudden onset of sleep during daily activities, in some cases without awareness or warning signs, has been reported uncommonly.
Slovenian: O nenadnih epizodah spanja med dnevnimi dejavnostmi, ki se pri nekaterih bolnikih pojavijo, ne da bi se jih zavedali ali brez opozorilnih znakov, ne poročajo pogosto.
English: Pramipexole doses as published in the literature refer to the salt form.
Slovenian: Odmerki pramipeksola, kot jih navajajo v literaturi, se nanašajo na sol.
English: Inhibitors/competitors of active renal elimination pathway Cimetidine reduced the renal clearance of pramipexole by approximately 34%, presumably by inhibition of the cationic secretory transport system of the renal tubules.
Slovenian: Zaviralci/snovi, ki tekmujejo za aktivno pot izločanja skozi ledvice Cimetidin je zmanjšal ledvični očistek pramipeksola za približno 34 %, verjetno z inhibicijo kationskega sekretornega transportnega sistema v ledvičnih tubulih.
English: Patients with psychotic disorders should only be treated with dopamine agonists if the potential benefits outweigh the risks.
Slovenian: Bolnike s psihotičnimi motnjami zdravimo z dopaminskimi agonisti samo takrat, kadar morebitna korist opravičuje tveganje.
English: The daily dose can be administered in two divided doses if creatinine clearance is between 20 and 50 ml/min, and as a single daily dose if creatinine clearance is less than 20 ml/min.
Slovenian: Dnevni odmerek lahko razdelimo na dva odmerka, če je kreatininski očistek med 20 in 50 ml/min, oziroma ga damo v enkratnem odmerku, če je kreatininski očistek manjši od 20 ml/min.
English: Patients with psychotic disorders
Slovenian: Bolniki s psihotičnimi motnjami
English: However, there was no significant difference during the maintenance phase.
Slovenian: V vzdrževalni fazi pa med zdraviloma ni bilo značilne razlike.
English: - Vision impairment.
Slovenian: - Motnje vida.
English: After switching to Oprymea prolonged-release tablets, the dose may be adjusted depending on the patient's therapeutic response (see section 5.1).
Slovenian: Po prehodu na Oprymea tablete s podaljšanim sproščanjem lahko njihov odmerek prilagodimo bolnikovemu odzivanju na zdravljenje (glejte poglavje 5.1).
English: Libido disorders Pramipexole may uncommonly be associated with libido disorders (increased or decreased).
Slovenian: Motnje libida Pramipeksol lahko občasno povzroči motnje libida (povečanje ali zmanjšanje).
English: - Uncontrollable excessive shopping or spending.
Slovenian: - čezmerno nakupovanje ali trošenje denarja, ki ju ne morete nadzorovati;
English: In a cross-sectional, retrospective screening and case-control study including 3,090 Parkinson's disease patients, 13.6% of all patients receiving dopaminergic or non-dopaminergic treatment had symptoms of an impulse control disorder during the past six months.
Slovenian: V presečni, retrospektivni presejalni raziskavi s kontrolno skupino, ki je zajela 3.090 bolnikov s Parkinsonovo boleznijo, je imelo 13,6 % vseh bolnikov, ki so prejemali dopaminergično ali nedopaminergično zdravljenje, v preteklih šestih mesecih simptome motnje nadzora impulzov.
English: The excretion of pramipexole into breast milk has not been studied in women.
Slovenian: Izločanja pramipeksola v materino mleko pri ženskah niso raziskovali.
English: Management of the overdose may require general supportive measures, along with gastric lavage, intravenous fluids, administration of activated charcoal and electrocardiogram monitoring.
Slovenian: Zdravljenje prevelikega odmerjanja lahko ob izpiranju želodca, dajanju intravenskih tekočin in aktivnega oglja ter spremljanju elektrokardiograma zahteva splošne podporne ukrepe.