FrancophonIA/ELRC3.0 huggingface dataset:
English: Before use, the powder needs to be dissolved in the liquid provided.
Slovenian: Pred uporabo je treba prašek raztopiti v priloženi tekočini.
English: Mean systemic arterial pressure was not significantly different between the two groups (-4.33 vs. -3.05 mm Hg).
Slovenian: Povprečni sistemski arterijski tlak se med skupinama ni značilno razlikoval (-4,33 v prim.
English: Six heparin-controlled studies and five emergency studies explored the place of epoprostenol in the general management of renal dialysis, using different techniques.
Slovenian: Šest s heparinom kontroliranih in pet urgentnih študij je raziskalo mesto epoprostenola v splošnem vodenju ledvične dialize z uporabo različnih tehnik.
English: • You feel that your heart is beating faster, or you have chest pain or shortness of breath.
Slovenian: • Čutite hitro bitje srca, imate bolečine v prsih ali kratko sapo.
English: Infusion of 4 nanograms/kg/min for 30 minutes have been shown to have no significant effect on heart rate or blood pressure, although facial flushing may occur at these levels.
Slovenian: Ugotovljeno je, da infundiranje 4 nanogramov/kg/min 30 minut ne vpliva pomembno na srčno frekvenco ali krvni tlak, lahko pa se pri tej hitrosti pojavi zardevanje obraza.
English: Mix well.
Slovenian: Dobro premešajte.
English: To establish that renal dialysis patients at increased risk of haemorrhage bleed less frequently with epoprostenol than heparin, 2 major prospectively controlled studies were conducted.
Slovenian: Za ugotavljanje, da imajo bolniki na ledvični dializi, ki imajo večje tveganje za krvavitve, z epoprostenolom krvavitve manj pogosto kot s heparinom, sta bili izvedeni 2 veliki prospektivni kontrolirani študiji.
English: In general, events seen after overdose of Flolan represent exaggerated pharmacological effects of the drug (e.g. hypotension and complications of hypotension).
Slovenian: Na splošno predstavljajo dogodki, opaženi po prevelikem odmerjanju zdravila Flolan, prekomerne farmakološke učinke zdravila (npr. hipotenzija in zapleti hipotenzije).
English: Increases in dose should be considered if symptoms of pulmonary arterial hypertension persist, or recur after improving.
Slovenian: Povečanje odmerka pride v poštev, če simptomi pljučne arterijske hipertenzije trajajo ali se po izboljšanju ponovijo.
English: Blood glucose increased * Associated with the delivery system for Flolan 1 Catheter-related infections caused by organisms not always considered pathogenic (including micrococcus) have been reported.
Slovenian: * Povezano z aplikacijskim sistemom za zdravilo Flolan 1 Opisane so bile s katetrom povezane okužbe z organizmi, ki ne veljajo vedno za patogene (vključno z mikrokoki).
English: Treatment should only be initiated and monitored by a physician experienced in the treatment of pulmonary arterial hypertension.
Slovenian: Zdravljenje sme vpeljati in nadzorovati le zdravnik, ki ima izkušnje z zdravljenjem pljučne arterijske hipertenzije.
English: Flolan is indicated for use in haemodialysis in emergency situations when use of heparin carries a high risk of causing or exacerbating bleeding or when heparin is otherwise contraindicated (see section 5.1).
Slovenian: Zdravilo Flolan je indicirano za uporabo pri hemodializi v nujnih okoliščinah, kadar uporabo heparina spremlja veliko tveganje za poslabšanje krvavitev, ali kadar je heparin kako drugače kontraindiciran (glejte poglavje 5.1).
English: They should be kept under 25°C and protected from light.
Slovenian: Shranjevati jo je treba pri temperaturi do 25 °C in zaščiteno pred svetlobo.
English: Once Flolan powder has been dissolved, and diluted, it should ideally be used immediately.
Slovenian: Ko je prašek zdravila Flolan raztopljen in razredčen, ga je najbolje uporabiti nemudoma.
English: Once the best dose has been found, a permanent tube (line) will be fitted into one of your veins.
Slovenian: Ko bo določen najprimernejši odmerek, vam bodo v eno od ven namestili stalno cevko (kateter).
English: Effect of Flolan on blood pressure and heart rate
Slovenian: Vpliv zdravila Flolan na krvni tlak in srčni utrip
English: Following establishment of a new infusion rate, the patient should be observed, and erect and supine blood pressure and heart rate monitored for several hours to ensure that the new dose is tolerated.
Slovenian: Po določitvi nove hitrosti infundiranja je treba bolnika opazovati ter mu več ur kontrolirati krvni tlak in srčno frekvenco stoje in leže ter se tako prepričati, da prenese novi odmerek.
English: Elevated cAMP levels regulate intracellular calcium concentrations by stimulating calcium removal, and thus platelet aggregation is ultimately inhibited by the reduction of cytoplasmic calcium, upon which platelet shape change, aggregation and the release reaction depends.
Slovenian: Zvišana koncentracija cAMP uravnava znotrajcelično koncentracijo kalcija s stimulacijo odstranjevanja kalcija, tako da agregacijo trombocitov navsezadnje zavre znižanje kalcija v citoplazmi, od katerega so odvisne sprememba oblike trombocitov, njihova agregacija in reakcija sproščanja.
English: Your treatment may have an effect on the ability to drive or use machinery.
Slovenian: Vaše zdravilo lahko vpliva na sposobnost upravljanja vozil ali strojev.
English: Intravenously administered epoprostenol is rapidly distributed from blood to tissue.
Slovenian: Intravensko dani epoprostenol se iz krvi hitro porazdeli v tkiva.
English: Flolan is suitable for continuous infusion only, either intravascularly or into the blood supplying the dialyser.
Slovenian: Zdravilo Flolan je primerno le za stalno infundiranje, bodisi intravaskularno bodisi v kri, ki priteka v dializator.
English: Following the administration of radiolabelled epoprostenol to humans, the urinary and faecal recoveries of radioactivity were 82% and 4%, respectively.
Slovenian: Po uporabi radioaktivno označenega epoprostenola pri človeku se je v urinu pojavilo 82 % radioaktivnosti in v blatu 4 %.
English: Infusion rate (mL/h) = Infusion rate (mL/min) x 60
Slovenian: Hitrost infundiranja (ml/h) = hitrost infundiranja (ml/min) x 60
English: Once Flolan has been dissolved and diluted, any unused solution can be stored at 25oC and used within 12 hours.
Slovenian: Ko je zdravilo Flolan raztopljeno in razredčeno, je morebiti neporabljeno raztopino mogoče shraniti pri temperaturi 25 oC in jo uporabiti v 12 urah.
English: Many of the actions of epoprostenol are exerted via the stimulation of adenylate cyclase, which leads to increased intracellular levels of cyclic adenosine 3'5' monophosphate (cAMP).
Slovenian: Številna delovanja epoprostenola potekajo s stimulacijo adenilat-ciklaze, ki poveča znotrajcelično koncentracijo cikličnega adenozin-3'5'-monofosfata (cAMP).
English: Symptoms of overdose may include headache, nausea, vomiting, fast heart rate, warmth or tingling, or feeling like you might pass out (feeling faint/dizziness).
Slovenian: Med simptomi prevelikega odmerjanja so lahko glavobol, slabost, bruhanje, hitro bitje srca, občutek toplote ali mravljinčenja ali občutek, da boste omedleli (omedlevica/omotica).
English: Reconstitution and dilution should be carried out immediately prior to use.
Slovenian: Pripravo in razredčenje je treba opraviti tik pred uporabo.
English: Flolan is indicated for the treatment of pulmonary arterial hypertension (PAH) (idiopathic or heritable PAH and PAH associated with connective tissue diseases) in patients with WHO Functional Class III-IV symptoms to improve exercise capacity (see section 5.1).
Slovenian: Zdravilo Flolan je indicirano za zdravljenje pljučne arterijske hipertenzije (PAH) (idiopatske ali dedne PAH in PAH, povezane z vezivnotkivnimi boleznimi) pri bolnikih s simptomi funkcijskega razreda III-IV po Svetovni zdravstveni organizaciji (SZO) za izboljšanje obremenitvene sposobnosti (glejte poglavje 5.1).
English: The other ingredients are Mannitol, Glycine, Sodium Chloride, Sodium Hydroxide and Water.
Slovenian: Pomožne snovi so manitol, glicin, natrijev klorid, natrijev hidroksid in voda.
English: Epoprostenol is the most potent inhibitor of platelet aggregation known.
Slovenian: Epoprostenol je najmočnejši znani zaviralec agregacije trombocitov.
English: What Flolan is and what it is used for What you need to know before you take Flolan How to take Flolan
Slovenian: Kaj je zdravilo Flolan in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Flolan Kako jemati zdravilo Flolan Možni neželeni učinki
English: • medicines used to treat high blood pressure
Slovenian: • zdravila za zdravljenje visokega krvnega tlaka,
English: The half-life for the spontaneous breakdown to 6-oxo-prostaglandin F1 alpha in man is expected to be no more than 6 minutes, and may be as short as 2 to 3 minutes, as estimated from in vitro rates of degradation of epoprostenol in human whole blood.
Slovenian: Pričakovani razpolovni čas spontane razgradnje v 6-okso-prostaglandin F1 alfa pri človeku ne presega 6 minut in je morda celo samo od 2 do 3 minute, če ocenjujemo glede na hitrost razgradnje epoprostenola v človeški polni krvi in vitro.
English: Thus, therapy with Flolan requires commitment by the patient to sterile drug reconstitution, drug administration, care of the permanent central venous catheter, and access to intense and ongoing patient education.
Slovenian: Zato zdravljenje z zdravilom Flolan zahteva, da bolnik skrbi za sterilno pripravo in dajanje zdravila, oskrbo stalnega centralnega venskega katetra ter možnost intenzivnega in stalnega izobraževanja.
English: At week 12, NYHA functional class improved in 21 of 51 (41%) patients treated with epoprostenol compared to none of the 48 patients treated with conventional therapy alone.
Slovenian: Po 12 tednih se je funkcijski razred po NYHA izboljšal pri 21 od 51 (41 %) bolnikov, zdravljenih z epoprostenolom, in pri nobenem od 48 bolnikov, ki so prejemali samo konvencionalno zdravljenje.
English: An abrupt interruption of therapy can induce a rebound of pulmonary arterial hypertension resulting in dizziness, asthenia, increase dyspnoea, and may lead to death (see section 4.2).
Slovenian: Nenadna prekinitev zdravljenja lahko povzroči preobratno pljučno arterijsko hipertenzijo s posledično omotico, astenijo, poslabšanjem dispneje ter lahko povzroči smrt (glejte poglavje 4.2).
English: If you take more Flolan than you should
Slovenian: Če ste vzeli večji odmerek zdravila Flolan, kot bi smeli
English: You will start with an infusion of Flolan.
Slovenian: Zdravljenje boste začeli z infuzijo zdravila Flolan.
English: Your dose may need to be reduced or your infusion stopped.
Slovenian: Morda vam bo moral zmanjšati odmerek ali prekiniti infundiranje zdravila.
English: However, the reverse was observed for postdialysis days with epoprostenol (N=1/5) compared to heparin (N=8/16).
Slovenian: Obratno pa je bilo ugotovljeno za dneve po dializi z epoprostenolom (n = 1/5) v primerjavi s heparinom (n = 8/16).
English: It is unknown if epoprostenol or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se epoprostenol ali njegovi presnovki pri človeku izločajo v materino mleko.
English: PHARMACEUTICAL FORM Powder for concentrate for solution for infusion: - White or off-white freeze dried powder Solvent for parenteral use: - Clear, colourless solution (pH 10.3 - 10.8)
Slovenian: FARMACEVTSKA OBLIKA Prašek za koncentrat za raztopino za infundiranje: - bel ali skoraj bel liofiliziran prašek Vehikel za parenteralno uporabo: - bistra, brezbarvna raztopina (pH 10,3-10,8)
English: Pain at the injection site*, chest pain
Slovenian: Pogosti bolečine na mestu injiciranja*, bolečina v prsih
English: Independent of technical difficulties which occurred rarely with either treatment, major dialysis-limiting clotting did not occur in 93% of all epoprostenol dialyses and 99% of all heparin dialyses.
Slovenian: Neupoštevaje tehnične težave (ki so bile pri obeh načinih zdravljenja redke) se pomembno strjevanje, ki bi omejilo dializo, ni pojavilo pri 93 % vseh dializ z epoprostenolom in pri 99 % vseh dializ s heparinom.
English: • feeling tired, weak
Slovenian: • utrujenost, šibkost.
English: For further instructions on reconstitution and dilution of the medicinal product before administration, (see section 6.6).
Slovenian: Za dodatna navodila o pripravi in razredčenju zdravila pred uporabo glejte poglavje 6.6.
English: Dry mouth
Slovenian: Občasni suha usta
English: During long-term infusion, the occurrence of dose-related pharmacological events similar to those observed during the dose-ranging period may necessitate a decrease in infusion rate, but the adverse reactions may occasionally resolve without dosage adjustment.
Slovenian: Med dolgotrajnim infundiranjem se lahko pojavijo z odmerkom povezani farmakološki učinki, podobni tistim med obdobjem ugotavljanja odmerka, in lahko zahtevajo zmanjšanje hitrosti infundiranja, neželeni učinki pa občasno lahko minejo brez prilagajanja odmerka.
English: However, more patients in both treatment groups (28/51 [55%] with epoprostenol and 35/48 [73%] with conventional therapy alone) showed no change in functional class, and 2/51 (4%) with epoprostenol and 13/48 (27%) with conventional therapy alone worsened.
Slovenian: Vendar pa se funkcijski razred pri večjem delu bolnikov v obeh terapevtskih skupinah ni spremenil (28/51 [55 %] z epoprostenolom in 35/48 [73 %] s konvencionalnim zdravljenjem samim), pri 2/51 (4 %) z epoprostenolom in 13/48 (27 %) s konvencionalnim zdravljenjem samim pa se je poslabšal.
English: Flolan is contraindicated in patients: • with known hypersensitivity to the active substance(s) or to any of the excipients listed in section
Slovenian: Zdravilo Flolan je kontraindicirano pri bolnikih: • z znano preobčutljivostjo na zdravilno učinkovino ali katero koli pomožno snov, navedeno v poglavju
English: METHOD AND ROUTE(S) OF ADMINISTRATION The powder needs to be reconstituted and diluted before infusion.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Prašek je treba pred infundiranjem pripraviti in razredčiti.
English: General Disorders and Administration Site Conditions Very common Pain (unspecified) Common
Slovenian: Splošne težave in spremembe na mestu aplikacije Zelo pogosti bolečina (neopredeljena)
English: The infusion rate should be increased by 1 to 2 nanograms/kg/min increments at intervals sufficient to allow assessment of clinical response; these intervals should be of at least 15 min.
Slovenian: Hitrost infundiranja je treba povečevati po 1 do 2 nanograma/kg/min v presledkih, ki zadoščajo za oceno kliničnega odziva; ti presledki morajo trajati vsaj 15 minut.
English: Epoprostenol is only indicated for continuous infusion by intravenous route.
Slovenian: Epoprostenol je indiciran le za stalno intravensko infundiranje.
English: Visible clotting (not necessitating intervention) was reported in another 31% of epoprostenol dialyses and 5% of heparin dialyses.
Slovenian: Vidno strjevanje (ki ni zahtevalo ukrepanja) so zabeležili pri dodatnih 31 % dializ z epoprostenolom in 5 % dializ s heparinom.
English: • pale skin
Slovenian: • bleda koža,
English: Common side effects that may show up in blood tests • decrease in the number of blood platelets (cells that help the blood to clot)
Slovenian: Pogosti neželeni učinki, ki se lahko pokažejo pri preiskavah krvi • zmanjšanje števila krvnih ploščic (trombocitov; to so celice, ki sodelujejo pri strjevanju krvi).
English: Effects on platelets have been found to disappear within 2 hours of discontinuing the infusion, and haemodynamic changes due to epoprostenol to return to baseline within 10 minutes of termination of 60 minutes infusion at 1 to 16 nanograms/kg/min.
Slovenian: Ugotovljeno je, da učinki na trombocite izginejo v 2 urah po koncu infundiranja, hemodinamske spremembe zaradi epoprostenola pa se vrnejo na izhodiščne vrednosti v 10 minutah po koncu 60-minutnega infundiranja od 1 do 16 nanogramov/kg/min.
English: There are no data regarding the effect of Flolan used in renal dialysis on the ability to drive or operate machinery.
Slovenian: Podatkov o vplivu zdravila Flolan, uporabljenega pri ledvični dializi, na sposobnost vožnje in upravljanja s stroji ni.
English: Keep container in the outer carton to protect from light.
Slovenian: Vsebnik shranjujte v zunanji ovojnini za zagotovitev zaščite pred svetlobo.
English: Very rare
Slovenian: Zelo redki bledica
English: • stomach discomfort or pain
Slovenian: • nelagodje ali bolečine v želodcu,
English: Epoprostenol must not be administered as a bolus injection
Slovenian: Epoprostenola se ne sme dajati v bolusni injekciji.
English: Flolan is used to prevent blood clotting during kidney dialysis when heparin cannot be used.
Slovenian: Zdravilo Flolan se uporablja za preprečevanje krvnih strdkov med ledvično dializo, kadar ni mogoče uporabiti heparina.
English: Reconstitution, dilution and calculation of infusion rate:
Slovenian: Priprava, razredčenje in izračun hitrosti infundiranja:
English: Flolan may either decrease or increase heart rate.
Slovenian: Zdravilo Flolan lahko poveča ali zmanjša srčno frekvenco.
English: Infusion rate formulae - examples
Slovenian: Formule - primeri za hitrost infundiranja
English: If you are being given Flolan using an infusion pump, a ‘cold pouch' may be used to maintain the temperature of the solution.
Slovenian: Če zdravilo Flolan prejemate z infuzijsko črpalko, lahko za vzdrževanje temperature raztopine uporabite "hladno vrečko".
English: Stopping Flolan must be done gradually.
Slovenian: Prenehanje uporabe zdravila Flolan mora biti opravljeno postopoma.
English: Sodium Hydroxide (for pH adjustment)
Slovenian: Natrijev hidroksid (za prilagoditev pH)
English: Preparation of Flolan intravenous injectable solution:
Slovenian: Priprava raztopine Flolan za intravensko injiciranje:
English: For administration using a pump capable of delivering small volume constant infusions, suitable aliquots of concentrated solution may be diluted with sterile sodium chloride 0.9% w/v solution.
Slovenian: Za uporabo s črpalko, ki lahko daje majhno stalno količino infuzije, je treba ustrezne alikvote koncentrirane raztopine razredčiti s sterilno 0,9 % (m/v) raztopino natrijevega klorida.
English: The decision to administer Flolan for pulmonary arterial hypertension should be based upon the patient's understanding that there is a high likelihood that therapy with Flolan will be needed for prolonged periods, possibly years, and the patient's ability to accept and care for a permanent i.v.
Slovenian: Odločitev za uporabo zdravila Flolan pri pljučni arterijski hipertenziji mora temeljiti na bolnikovem razumevanju, da bo zdravljenje zelo verjetno potrebno dolgo časa, morda leta, in bolnikovo zmožnostjo, da sprejme in skrbi za stalni intravenski kateter ter infuzijsko črpalko.
English: Flolan is a potent pulmonary and systemic vasodilator.
Slovenian: Zdravilo Flolan je močan pljučni in sistemski vazodilatator.
English: It may be diluted with sodium chloride 0.9% w/v solution, provided a ratio of 6 volumes of sodium chloride 0.9% w/v solution to 1 volume of concentrated solution is not exceeded e.g. 50 mL of concentrated solution further diluted with a maximum of 300 mL sodium chloride 0.9% w/v solution.
Slovenian: Razredčiti jo je mogoče z 0,9 % (m/v) raztopino natrijevega klorida, pod pogojem, da ni preseženo razmerje 6 delov 0,9 % (m/v) raztopine natrijevega klorida na 1 del koncentrirane raztopine, npr. 50 ml koncentrirane raztopine, nadalje razredčene z največ 300 ml 0,9 % (m/v) raztopine natrijevega klorida.
English: Intravenous epoprostenol infusions of up to 15 minutes have been found to produce dose-related increases in cardiac index (CI) and stroke volume (SV), and dose-related decreases in pulmonary vascular resistance (PVR), total pulmonary resistance (TPR) and mean systemic arterial pressure (SAPm).
Slovenian: Do 15-minutno intravensko infundiranje epoprostenola povzroči od odmerka odvisno povečanje srčnega indeksa (CI - cardiac index) in utripnega volumna (SV - stroke volume) ter od odmerka odvisno zmanjšanje pljučnega žilnega upora (PVR - pulmonary vascular resistance), celotnega pljučnega upora (TPR - total pulmonary resistance) in srednjega sistemskega arterijskega tlaka (SAPm - mean systemic arterial pressure).
English: Flolan widens the blood vessels to lower the blood pressure in the lungs.
Slovenian: Zdravilo Flolan razširi žile in tako zniža krvni tlak v pljučih.
English: Freshly prepared epoprostenol solutions for the treatment of pulmonary arterial hypertension should be used within 12 hours at 25°C, or stored for up to 40 hours at between 2 to 8°C and then used within 8 hours at
Slovenian: Sveže pripravljeno raztopino epoprostenola za zdravljenje pljučne arterijske hipertenzije je treba uporabiti v 12 urah pri temperaturi 25 °C, lahko pa se jo do 40 ur hrani pri temperaturi od 2 do 8 °C in nato uporabi v 8 urah pri temperaturi 25 °C.
English: Sodium Hydroxide (for pH adjustment) Water for Injection
Slovenian: Natrijev hidroksid (za prilagoditev pH) Voda za injekcije
English: If you have been fitted with a ‘line' into a vein it is very important to keep this area clean, otherwise you could get an infection.
Slovenian: Zato je zelo pomembno, da ohranjate to mesto čisto, ker se vam sicer lahko pojavi okužba.
English: Skin damage at the injection site
Slovenian: Poškodba kože na mestu injiciranja
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Solvent for parenteral use for Flolan
Slovenian: IME ZDRAVILA IN POT(I) UPORABE Vehikel za parenteralno uporabo za zdravilo Flolan intravenska uporaba
English: Reconstituted solutions, prepared in real time, must not be administered over more than 12 hours when they are used at room temperature (between 15°C and 25°C).
Slovenian: Pripravljene raztopine, pripravljene v realnem času, se ne sme dajati več kot 12 ur, če je uporabljena pri sobni temperaturi (med 15 in 25 °C).
English: This SmPC, labelling and package leaflet is the version valid at the time of Commission decision.
Slovenian: Opomba: Ta različica povzetka glavnih značilnosti zdravila, označevanja in navodila za uporabo je različica, ki je v veljavi v času sprejema odločbe Komisije.
English: Sixteen patients received 24 epoprostenol dialyses in emergency studies.
Slovenian: V urgentnih študijah je 16 bolnikov prejelo 24 dializ z epoprostenolom.
English: Endocrine Disorders
Slovenian: Bolezni endokrinega sistema
English: Initially a pack containing solvent for parenteral use must be used.
Slovenian: Uvodoma je treba uporabiti pakiranje, ki vsebuje vehikel za parenteralno uporabo.
English: When used in renal dialysis Flolan may be administered as the concentrated solution (a) or in diluted form (b).
Slovenian: Med uporabo pri ledvični dializi se lahko zdravilo Flolan daje kot koncentrirana raztopina (a) ali v razredčeni obliki (b).
English: Very common Facial flushing (seen even in the anaesthetised patient) Common
Slovenian: Žilne bolezni Zelo pogosti zardevanje obraza (opazno celo pri anesteziranih bolnikih)
English: • build up of fluid in the lungs (pulmonary oedema)
Slovenian: • kopičenje tekočine v pljučih (pljučni edem),
English: To dilute the concentrated solution, draw it up into a larger syringe and then attach the sterile filter provided to the syringe.
Slovenian: Za razredčenje koncentrirane raztopine jo izvlecite v večjo brizgo in nato namestite priloženi sterilni filter.
English: Flolan is infused continuously through a permanent indwelling central venous catheter via a small, portable infusion pump.
Slovenian: Zdravilo Flolan se infundira v stalni infuziji po stalnem centralnem venskem katetru z majhno, prenosno infuzijsko črpalko.
English: Flolan has been successfully used instead of heparin in renal dialysis but in a small proportion of dialyses clotting has developed in the dialysis circuit, requiring termination of dialysis.
Slovenian: Zdravilo Flolan so pri ledvični dializi uspešno uporabljali namesto heparina, a pri majhnem deležu bolnikov je prišlo do strjevanja v dializnem obtoku, tako da je bilo treba z dializo prenehati.