FrancophonIA/ELRC3.0 huggingface dataset:
English: During long-term therapy, reduced peripheral resistance contributes to the blood pressure reduction.
Danish: Ved langtidsbehandling bidrager den nedsatte perifere modstand til blodtryksreduktionen.
English: Your resistance to infection may be decreased and you may notice tiredness, an infection or a fever.
Danish: Din modstandsdygtighed over for infektioner kan blive nedsat, og du bemærker måske træthed, en infektion eller feber.
English: If you are going to have an operation, tell your doctor or dentist that you are taking Atacand Plus.
Danish: Hvis du skal opereres, skal du fortælle din læge eller tandlæge, at du tager Atacand Plus.
English: Medicines to treat cancer.
Danish: • Medicin til behandling af cancer (kræft).
English: The major physiological effects of angiotensin II, such as vasoconstriction, aldosterone stimulation, regulation of salt and water homeostasis and stimulation of cell growth, are mediated via the type 1 (AT1) receptor.
Danish: De vigtigste fysiologiske virkninger af angiotensin II, såsom vasokonstriktion, aldosteronstimulering, regulering af salt- og vandbalancen og stimulering af cellevæksten, medieres via type 1 (AT1)-receptoren.
English: An increased amount of cholesterol, sugar or uric acid in your blood.
Danish: Forhøjet indhold af kolesterol, sukker eller urinsyre i blodet.
English: No specific information is available on the treatment of overdose with Atacand Plus.
Danish: Der findes ingen specifikke oplysninger om behandling af Atacand Plus-overdosis.
English: The plasma protein binding of hydrochlorothiazide is approximately 60%.
Danish: Plasmaproteinbindingen af hydrochlorthiazid er ca. 60 %.
English: Acetylsalicylic acid (if you are taking more than 3 g each day) (medicine to relieve pain and inflammation).
Danish: • Acetylsalicylsyre (hvis du tager mere end 3 gram dagligt) (smertestillende medicin og medicin mod inflammation).
English: There were no qualitative new toxic findings with the combination compared to that observed for each component.
Danish: Kvalitativt var der ingen nye fund af toksikologisk art ved kombinationen sammenlignet med observationerne for hver enkelt komponent.
English: 6.6 Special precautions for disposal and other handling No special requirements
Danish: 6.6 Regler for destruktion og anden håndtering Ingen særlige forholdsregler.
English: No pharmacokinetic interactions of clinical significance were identified in these studies.
Danish: Der er ikke påvist klinisk signifikante farmakokinetiske interaktioner i disse studier.
English: Large clinical studies have shown that long-term treatment with hydrochlorothiazide reduces the risk for cardiovascular morbidity and mortality.
Danish: Store kliniske undersøgelser har vist, at langtidsbehandling med hydrochlorthiazid nedsætter risikoen for kardiovaskulær morbiditet og mortalitet.
English: Atacand Plus and associated names (see Annex I) 8 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 16 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 32 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 32 mg/25 mg tablets
Danish: Atacand Plus og tilhørende navne (se Bilag I) 8 mg/12,5 mg tabletter Atacand Plus og tilhørende navne (se Bilag I) 16 mg/12,5 mg tabletter Atacand Plus og tilhørende navne (se Bilag I) 32 mg/12,5 mg tabletter Atacand Plus og tilhørende navne (se Bilag I) 32 mg/25 mg tabletter
English: Total plasma clearance of candesartan is about 0.37 ml/min/kg, with a renal clearance of about 0.19 ml/min/kg.
Danish: Candesartans totale plasmaclearance er ca. 0,37 ml/min/kg med en renal clearance på ca. 0,19 ml/min/kg.
English: The recommended dose of Atacand Plus is one tablet once daily.
Danish: Den anbefalede dosis Atacand Plus er én tablet én gang dagligt.
English: If calcium supplements or Vitamin D must be prescribed, serum calcium levels should be monitored and the dose adjusted accordingly.
Danish: Hvis det er nødvendigt at ordinere calciumtilskud eller D-vitamin, skal serum-calcium monitoreres og dosis justeres i overensstemmelse hermed.
English: The patient should be placed supine with the legs elevated.
Danish: Patienten skal ligge på ryggen med eleverede ben.
English: Atacand Plus is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Danish: Atacand Plus bør ikke anvendes af mødre, der ammer, og din læge kan vælge en anden behandling til dig, hvis du ønsker at amme, især hvis dit barn er nyfødt eller blev født for tidligt.
English: Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter.
Danish: Patienter bør være tilstrækkeligt hydrerede, og monitorering af nyrefunktionen efter påbegyndelse af samtidig behandling og periodisk herefter bør overvejes.
English: Exacerbation or activation of systemic lupus erythaematosus has been reported with the use of thiazide diuretics.
Danish: Forværring eller aktivering af systemisk lupus erythematosus har været rapporteret ved anvendelse af thiaziddiuretika.
English: There is no indication of serious or exaggerated first dose hypotension or rebound effect after cessation of treatment.
Danish: Der er ingen tegn på alvorlig eller kraftig hypotension efter første dosis eller rebound-effekt efter behandlingsophør.
English: Postural hypotension may become aggravated by simultaneous intake of alcohol, barbiturates or anaesthetics.
Danish: Ortostatisk hypotension kan forværres ved samtidig indtagelse af alkohol, barbiturater eller anæstetika.
English: Serum electrolyte and acid balance should be checked and corrected, if needed.
Danish: Serumelektrolytter og syrebalancen skal kontrolleres og om nødvendigt korrigeres.
English: Do not take Atacand Plus if: you are allergic (hypersensitive) to candesartan cilexetil or hydrochlorothiazide or any of the other ingredients of Atacand Plus (see section 6).
Danish: Tag ikke Atacand Plus: - hvis du er overfølsom (allergisk) over for candesartancilexetil eller hydrochlorthiazid eller et af de øvrige indholdsstoffer i Atacand Plus (se pkt.
English: Atacand Plus can affect the way some other medicines work and some medicines can have an effect on Atacand Plus.
Danish: Atacand Plus kan påvirke måden, anden medicin virker på, og anden medicin kan påvirke Atacand Plus.
English: There were 26.7 events per 1000 patient-years in the candesartan group versus 30.0 events per 1000 patientyears in the control group (relative risk 0.89, 95% CI 0.75 to 1.06, p=0.19).
Danish: Der var 26,7 hændelser pr. 1.000 patientår i candesartan-gruppen versus 30,0 hændelser pr. 1.000 patientår i kontrolgruppen (relativ risiko 0,89; 95 % konfidensinterval 0,75-1,06; p= 0,19).
English: This causes moderate to severe pain in the stomach.
Danish: Dette medfører moderate til voldsomme mavesmerter.
English: Alcohol may make you feel faint or dizzy.
Danish: Alkohol kan få dig til at føle dig utilpas eller svimmel.
English: Tingling or prickling in your arms or legs.
Danish: • Snurrende eller prikkende fornemmelse i dine arme eller ben.
English: When clinically appropriate a direct change from monotherapy to Atacand Plus may be considered.
Danish: Hvis det er klinisk relevant, kan et direkte skift fra monoterapi til Atacand Plus overvejes.
English: Calcium or Vitamin D supplements.
Danish: • Calciumtilskud eller D-vitamintilskud.
English: Atacand Plus may cause increased sensitivity of the skin to sun.
Danish: Atacand Plus kan forårsage, at huden bliver mere følsom for sollys.
English: Like all medicines, Atacand Plus can cause side effects, although not everybody gets them.
Danish: Atacand Plus kan som al anden medicin give bivirkninger, men ikke alle får bivirkninger.
English: severe itching of the skin (with raised lumps).
Danish: • alvorlig hudkløe (med hævelser af huden).
English: Candesartan does not influence ACE or other enzyme systems usually associated with the use of ACE inhibitors.
Danish: Candesartan påvirker ikke ACE eller andre enzymsystemer, der almindeligvis er forbundet med brugen af ACE-hæmmere.
English: Thiazides in high doses causing intense diuresis can inhibit the milk production.
Danish: Thiazider i høje doser, der medfører store diureser, kan hæmme mælkeproduktionen.
English: • Hydrochlorothiazide belongs to a group of medicines called diuretics (water tablets).
Danish: • Hydrochlorthiazid tilhører en gruppe lægemidler, der kaldes diuretika (vanddrivende medicin).
English: An increased or reduced amount of potassium in your blood, especially if you already have kidney problems or heart failure.
Danish: Forhøjet eller nedsat kaliumindhold i blodet, specielt hvis du i forvejen har nyreproblemer eller hjertesvigt.
English: The absolute bioavailability of candesartan is approximately 40% after an oral solution of candesartan cilexetil.
Danish: Den absolutte biotilgængelighed af candesartan er ca. 40 % efter en oral opløsning af candesartancilexetil.
English: Lithium (a medicine for mental health problems).
Danish: • Lithium (medicin til psykiske lidelser).
English: No gender related differences in the pharmacokinetics of candesartan have been observed.
Danish: Der er ikke observeret nogen forskel mellem kønnene for candesartans farmakokinetik.
English: Barbiturates (a type of sedative also used to treat epilepsy).
Danish: • Barbiturater (beroligende medicin, der også bruges til behandling af epilepsi).
English: The addition of hydrochlorothiazide did not significantly affect the outcome of foetal development studies in rats, mice or rabbits (see section 4.6).
Danish: Kombination med hydrochlorthiazid påvirkede ikke i betydende grad resultatet af fosterudviklings-undersøgelser hos rotter, mus eller kaniner (se pkt.
English: Hydrochlorothiazide is a sulfonamide derived active substance.
Danish: Hydrochlorthiazid er et sulfonamidafledt aktivt stof.
English: The apparent volume of distribution of candesartan is 0.1 l/kg.
Danish: Candesartans tilsyneladende fordelingsvolumen er 0,1 l/kg.
English: you have recently had a kidney transplant.
Danish: - hvis du for nyligt har fået transplanteret en nyre.
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded.
Danish: Epidemiologiske undersøgelser af risikoen for teratogenicitet ved behandling med ACE-hæmmere i første graviditetstrimester er inkonklusive, men en let øget risiko kan ikke udelukkes.
English: Treatment with candesartan cilexetil may cause hyperkalaemia, especially in the presence of heart failure and/or renal impairment.
Danish: Behandling med candesartancilexetil kan forårsage hyperkaliæmi, især ved tilstedeværelse af hjerteinsufficiens og/eller nyreinsufficiens.
English: Diuretic-induced hypokalaemia and hypomagnesaemia predisposes to the potential cardiotoxic effects of digitalis glycosides and antiarrhythmics.
Danish: Diuretika-induceret hypokaliæmi og hypomagnesiæmi prædisponerer for den potentielt kardiotoksiske effekt af digitalis-glykosider og antiarytmika.
English: you are vomiting, have recently had severe vomiting, or have diarrhoea.
Danish: - hvis du kaster op, har kastet meget op for nyligt eller har diarré.
English: Candesartan and hydrochlorothiazide have additive antihypertensive effects.
Danish: Candesartan og hydrochlorthiazid har additive antihypertensive virkninger.
English: Pharmacokinetics in special populations
Danish: Farmakokinetik hos specielle grupper
English: Thiazides may reduce the renal excretion of cytotoxic medicinal products (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Danish: Thiazider kan reducere den renale ekskretion af cytotoksiske lægemidler (f.eks. cyclophosphamid, methotrexat) og potensere deres myelosuppressive effekt.
English: Hydrochlorothiazide is rapidly absorbed from the gastrointestinal tract with an absolute bioavailability of approximately 70%.
Danish: Hydrochlorthiazid absorberes hurtigt fra mave-tarm-kanalen med en absolut biotilgængelighed på ca. 70 %.
English: Candesartan cilexetil/hydrochlorothiazide is similarly effective in patients irrespective of age and gender.
Danish: Candesartancilexetil/hydrochlorthiazid er lige effektivt hos patienter uanset alder og køn.
English: The risk for hypokalaemia may be increased in patients with cirrhosis of the liver, in patients experiencing brisk diuresis, in patients with an inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or adrenocorticotropic hormone (ACTH).
Danish: Risikoen for hypokaliæmi kan være højere hos patienter med levercirrose, hos patienter med stor diurese, hos patienter med utilstrækkelig oral indtagelse af elektrolytter og hos patienter i samtidig behandling med kortikosteroider eller adrenokortikotropt hormon (ACTH).
English: Candesartan and hydrochlorothiazide both show genotoxic activity at very high concentrations/doses.
Danish: Såvel candesartan som hydrochlorthiazid viste genotoksisk aktivitet ved meget høje koncentrationer/doser.
English: Candesartan caused a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit).
Danish: Candesartan forårsagede en reduktion af parametre for de røde blodlegemer (erytrocytter, hæmoglobin, hæmatokrit).
English: Candesartan is mainly eliminated unchanged via urine and bile and only to a minor extent eliminated by hepatic metabolism (CYP2C9).
Danish: Candesartan elimineres overvejende uomdannet via urin og galde og elimineres kun i ringe grad via levermetabolisering (CYP2C9).
English: Common Weakness Rare
Danish: Almindelig Svaghed
English: Furthermore, candesartan induced hyperplasia/hypertrophy of the juxtaglomerular cells.
Danish: Endvidere inducerede candesartan hyperplasi/hypertrofi af de jukstaglomerulære celler.
English: When AIIRAs are administered simultaneously with non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Danish: Når AIIRA'er anvendes samtidigt med non-steroide antiinflammatoriske lægemidler (NSAID'er) (dvs. selektive COX-2-hæmmere, acetylsalicylsyre (>3 g/dag) og non-selektive NSAID'er), kan den antihypertensive effekt svækkes.
English: Medicines that can be affected by potassium blood levels such as some antipsychotic medicines.
Danish: • Medicin, der kan påvirkes af kaliumniveauet i blodet, som f.eks. visse antipsykotiske lægemidler.
English: The table below presents adverse reactions with hydrochlorothiazide monotherapy usually with doses of 25 mg or higher.
Danish: Nedenstående tabel viser bivirkninger med hydrochlorthiazid-monoterapi, almindeligvis med doser på 25 mg eller højere.
English: The renal excretion of potassium and magnesium increases dose-dependently, while calcium is reabsorbed to a greater extent.
Danish: Den renale udskillelse af kalium og magnesium øges dosisafhængigt, mens calcium reabsorberes i større omfang.
English: In two studies, both including patients with mild to moderate hepatic impairment, there was an increase in the mean AUC of candesartan of approximately 20% in one study and 80% in the other study (see section 4.2).
Danish: I to undersøgelser, der begge inkluderede patienter med let til moderat nedsat leverfunktion, var der en stigning i den gennemsnitlige AUC for candesartan på ca. 20 % i den ene undersøgelse og 80 % i den anden (se pkt.
English: If you forget to take use Atacand Plus Do not take a double dose to make up for a forgotten tablet.
Danish: Du må ikke tage en dobbeltdosis som erstatning for den glemte tablet.
English: In double-blind, randomised studies, the incidence of adverse events, especially cough, was lower during treatment with Atacand Plus than during treatment with combinations of ACE inhibitors and hydrochlorothiazide.
Danish: I dobbeltblindede, randomiserede undersøgelser var frekvensen af bivirkninger, især hoste, lavere ved behandling med Atacand Plus end ved behandling med kombinationer af ACE-hæmmere og hydrochlorthiazid.
English: Hypersensitivity to the active substances or to any of the excipients or to sulfonamide derived active substances.
Danish: Overfølsomhed over for de aktive stoffer, over for et eller flere af hjælpestofferne eller over for sulfonamidafledte aktive stoffer.
English: Always take Atacand Plus exactly as your doctor has told you.
Danish: Tag altid Atacand Plus nøjagtigt efter lægens anvisning.
English: Use in children
Danish: Behandling af børn
English: Amantadine (for the treatment of Parkinson's disease or for serious infections caused by viruses).
Danish: • Amantadin (til behandling af Parkinsons syge eller til alvorlige virusinfektioner).
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Danish: Spædbørn, hvis mødre har taget AIIRA'er, skal overvåges nøje for hypotension (se pkt.
English: Feeling dizzy/spinning sensation or weak.
Danish: • Svimmelhedsfølelse/snurrende fornemmelse eller følelse af svaghed.
English: Hypotension may occur during anaesthesia and surgery in patients treated with AIIRAs due to blockade of the renin-angiotensin system.
Danish: Der kan opstå hypotension under anæstesi og kirurgi hos patienter, der behandles med AIIRA'er, på grund af blokering af renin-angiotension-systemet.
English: In hypertensive patients, Atacand Plus results in a dose-dependent and long-lasting reduction in arterial blood pressure without reflex increase in heart rate.
Danish: Hos hypertensive patienter forårsager Atacand Plus en dosisafhængig og langvarig reduktion af det arterielle blodtryk uden reflektorisk stigning i hjertefrekvensen.
English: Hydrochlorothiazide inhibits the active reabsorption of sodium, mainly in the distal kidney tubules, and promotes the excretion of sodium, chloride and water.
Danish: Hydrochlorthiazid hæmmer den aktive reabsorption af natrium, overvejende i de distale nyretubuli, og fremmer udskillelsen af natrium, chlorid og vand.
English: Currently there are no data on the use of candesartan cilexetil/hydrochlorothiazide in patients with renal disease/nephropathy, reduced left ventricular function/congestive heart failure and post myocardial infarction.
Danish: Der er p.t. ingen data om brugen af candesartancilexetil/hydrochlorthiazid hos patienter med nyresygdom/nefropati, nedsat venstre ventrikelfunktion/hjerteinsufficiens og postmyokardieinfarkt.
English: Thiazides should be discontinued before carrying out tests for parathyroid function.
Danish: Thiazider skal seponeres, inden der foretages undersøgelse af parathyreoideafunktionen.
English: In elderly subjects (over 65 years), Cmax and AUC of candesartan are increased by approximately 50% and 80%, respectively in comparison to young subjects.
Danish: Hos ældre (> 65 år) er Cmax og AUC for candesartan øget med ca. 50 % henholdsvis 80 % sammenlignet med yngre forsøgspersoner.
English: Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Danish: Medmindre fortsat AIIRA-behandling anses for at være vigtig, bør patienter, der planlægger at blive gravide, skifte til alternativ antihypertensiv behandling med fastlagt sikkerhedsprofil ved brug under graviditet.
English: Cyclosporine, a medicine used for organ transplant to avoid organ rejection.
Danish: • Ciclosporin (bruges i forbindelse med organtransplantation for at undgå organafstødning).
English: The relative bioavailability of a tablet formulation of candesartan cilexetil compared with the same oral solution is approximately 34% with very little variability.
Danish: Den relative biotilgængelighed af tabletten candesartancilexetil sammenlignet med den orale opløsning er ca. 34 % med meget lille variation.
English: In patients with mild to moderate renal impairment, Cmax and AUC of candesartan increased during repeated dosing by approximately 50% and 70%, respectively, but the terminal t½ was not altered, compared to patients with normal renal function.
Danish: Hos patienter med let til moderat nedsat nyrefunktion steg Cmax og AUC for candesartan efter gentagne doser med henholdsvis ca. 50 % og 70 %, men den terminale t½ var uændret sammenlignet med patienter med normal nyrefunktion.
English: • Candesartan cilexetil belongs to a group of medicines called angiotensin II receptor antagonists.
Danish: • Candesartancilexetil tilhører en gruppe lægemidler, der kaldes angiotensin IIreceptorantagonister.
English: Jaundice (yellowing of the skin or the whites of your eyes).
Danish: • Gulsot (din hud eller det hvide i dine øjne får en gullig farve).
English: Respiratory infection.
Danish: • Luftvejsinfektion.
English: When Atacand Plus is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid levels is recommended.
Danish: Når Atacand Plus anvendes til patienter med nedsat nyrefunktion, anbefales regelmæssig monitorering af kalium-, kreatininog urinsyreniveauer.
English: The effects of candesartan cilexetil 8-16 mg (mean dose 12 mg) once daily on cardiovascular morbidity and mortality were evaluated in a randomised clinical trial with 4,937 elderly patients (aged 70-89 years, 21% aged 80 or above) with mild to moderate hypertension followed for a mean of 3.7 years (Study on COgnition and Prognosis in the Elderly).
Danish: Effekten af candesartancilexetil 8-16 mg (gennemsnitsdosis 12 mg) én gang dagligt på kardiovaskulær morbiditet og mortalitet blev undersøgt i et randomiseret klinisk forsøg med 4.937 ældre patienter (alder 70-89 år; 21 % på 80 år eller mere) med let til moderat hypertension, der blev fulgt i gennemsnitligt 3,7 år (Study on COgnition and Prognosis in the Elderly).
English: Increases in cholesterol and triglyceride levels have been associated with thiazide diuretic therapy.
Danish: Stigning i kolesterol- og triglyceridniveauer har været relateret til behandling med thiaziddiuretika.
English: Marked hypercalcaemia may be a sign of hidden hyperparathyroidism.
Danish: Udpræget hyperkalcæmi kan være tegn på skjult hyperparatyroidisme.
English: As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic heart disease or atherosclerotic cerebrovascular disease could result in a myocardial infarction or stroke.
Danish: Som ved ethvert antihypertensivt lægemiddel kan en kraftig blodtryksreduktion hos patienter med iskæmisk hjertesygdom eller aterosklerotisk cerebrovaskulær lidelse resultere i myokardieinfarkt eller apopleksi.
English: Data from in vitro and in vivo genotoxicity testing indicate that candesartan and hydrochlorothiazide are unlikely to exert any mutagenic or clastogenic activity under conditions of clinical use.
Danish: Data fra in vitro og in vivo genotoksicitetstests indikerer, at candesartan og hydrochlorthiazid næppe vil udøve nogen mutagen eller klastogen aktivitet ved klinisk anvendelse.
English: Atacand Plus is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Danish: Atacand Plus bør ikke tages tidligt i graviditeten og må ikke tages, hvis du er mere end 3 måneder henne, da det kan forårsage alvorlig skade på dit barn, hvis det tages efter tredje måned i graviditeten.
English: you have persistently high levels of calcium in your blood.
Danish: - hvis du har vedvarende højt calciumindhold i blodet.
English: Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Danish: Candesartan bindes ikke til og blokerer ikke andre af de hormonreceptorer eller ion-kanaler, der vides at spille en vigtig rolle i den kardiovaskulære regulering.
English: The safety and efficacy of Atacand Plus in children aged between birth and 18 years have not been established.
Danish: Atacand Pluss sikkerhed og virkning hos børn i alderen op til 18 år er ikke klarlagt.