FrancophonIA/ELRC3.0 huggingface dataset:
English: The Terrosa Pen can be used by self-injecting patients above the age of 18 years, healthcare professionals or third parties such as, for instance, adult relatives.
Croatian: Brizgalicu Terrosa Pen mogu primjenjivati samostalno bolesnici u dobi od 18 i više godina ili im je mogu primijeniti zdravstveni radnici ili treće osobe, primjerice odrasli srodnici.
English: Osteoporosis is also common in patients receiving medicines called corticosteroids.
Croatian: Osteoporoza se često javlja i u bolesnika koji primaju lijekove koji se nazivaju kortikosteroidi.
English: Do not transfer the medicine into a syringe.
Croatian: Nemojte prebacivati lijek u štrcaljku.
English: Use a new injection needle for each injection to prevent contamination and safely dispose of the needle after use.
Croatian: Upotrijebite novu iglu za svaku injekciju kako biste spriječili kontaminaciju i sigurno je zbrinite nakon uporabe.
English: The Terrosa Pen must not be used by blind or visually impaired patients without help from a trained able-bodied person.
Croatian: Brizgalicu Terrosa Pen ne smiju primjenjivati slijepi ni slabovidni bolesnici bez pomoći pravilno obučene i tjelesno sposobne osobe.
English: Teriparatide should not be used in paediatric patients (less than 18 years), or young adults with open epiphyses.
Croatian: Teriparatid se ne smije primjenjivati u pedijatrijskih bolesnika (mlađih od 18 godina) niti u mlađih odraslih osoba s otvorenim epifizama.
English: • if you have had radiation therapy involving your bones.
Croatian: ako ste primili terapiju zračenjem koja je obuhvaćala kosti.
English: Overdose experience based on post-marketing spontaneous reports
Croatian: Iskustva s predoziranjem iz spontanih prijava nakon stavljanja u promet
English: After each injection, the pen should be returned to the refrigerator.
Croatian: Nakon svake injekcije brizgalica se mora vratiti u hladnjak.
English: Terrosa may increase calcium in your blood or urine.
Croatian: Terrosa može povećati količinu kalcija u krvi ili mokraći.
English: The maximum total duration of treatment with teriparatide should be 24 months (see section 4.4).
Croatian: Ukupno trajanje liječenja teriparatidom smije iznositi najdulje 24 mjeseca (vidjeti dio 4.4).
English: This will keep the remaining Terrosa sterile and prevent leaking from the pen.
Croatian: To će očuvati ostatak lijeka Terrosa sterilnim i spriječiti curenje iz brizgalice.
English: Other common side effects (affecting up to 1 in 10 people) include feeling sick, headache and dizziness.
Croatian: Druge česte nuspojave (javljaju se u do 1 na 10 osoba) uključuju mučninu, glavobolju i omaglicu.
English: - Gently hold a fold of cleansed skin and insert the needle straight into the skin.
Croatian: - Nježno primite nabor očišćene kože i ubodite iglu ravno u kožu.
English: For the correct use of this medicine it is very important to closely follow the detailed Instructions for Use of your pen which are provided with the pen.
Croatian: Za ispravnu primjenu ovog lijeka vrlo je važno pažljivo slijediti detaljne upute za uporabu brizgalice koje su priložene uz brizgalicu.
English: Each cartridge and pen should be used by only one patient.
Croatian: Svaki uložak i brizgalicu smije koristiti samo jedan bolesnik.
English: The skeletal effects of teriparatide depend upon the pattern of systemic exposure.
Croatian: Učinci teriparatida na skelet ovise o obrascu sistemske izloženosti.
English: Make sure that the two indicator stripes are aligned.
Croatian: Uvjerite se da su dvije pokazne linije poravnate.
English: Results from up to 24 months (median: 19 months) treatment with teriparatide demonstrate statistically significant fracture reduction (Table 1).
Croatian: Rezultati liječenja teriparatidom u trajanju do 24 mjeseca (medijan: 19 mjeseci) pokazali su statistički značajno smanjenje broja prijeloma (Tablica 1).
English: If, by mistake, you have used more Terrosa than you should, contact your doctor or pharmacist.
Croatian: Ako ste greškom primijenili više lijeka Terrosa nego što ste trebali, javite se svom liječniku ili ljekarniku.
English: To avoid medication errors make sure that the date when starting to use a new cartridge is at least 28 days before its expiry date.
Croatian: Kako bi se izbjegle pogreške u primjeni lijeka, kod novog uloška pazite da je datum početka njegove primjene najmanje 28 dana prije isteka njegovog roka valjanosti.
English: No metabolism or excretion studies have been performed with teriparatide but the peripheral metabolism of parathyroid hormone is believed to occur predominantly in liver and kidney.
Croatian: Nisu provedena ispitivanja metabolizma niti izlučivanja teriparatida, no smatra se da se periferni metabolizam paratiroidnog hormona pretežno odvija u jetri i bubrezima.
English: Terrosa is used to treat osteoporosis in adults.
Croatian: Terrosa se koristi za liječenje osteoporoze u odraslih osoba.
English: The most common side effects are pain in limb (which may affect more than 1 in 10 people).
Croatian: Najčešće nuspojave su bol u udovima (može se javiti u više od 1 na 10 osoba).
English: • if you are pregnant or breast-feeding.
Croatian: ako ste trudni ili dojite.
English: Do not use your Terrosa Pen to inject any other medicine (e.g. insulin).
Croatian: Ne koristite Terrosa Pen za injektiranje drugog lijeka (npr. inzulina).
English: How do I reset the dose knob to the start position?
Croatian: Kako da vratim kotačić za doziranje u početni položaj?
English: • To set the fixed daily dose of 80 microliters, turn the dose knob clockwise until it stops and cannot be rotated any further.
Croatian: • Da biste namjestili fiksnu dnevnu dozu od 80 mikrolitara, okrećite kotačić za doziranje u smjeru kazaljke na satu sve dok se ne zaustavi i više se ne može okretati.
English: Children and adolescents Terrosa should not be used in children and adolescents (aged less than 18 years).
Croatian: Terrosa se ne smije primjenjivati u djece i adolescenata (mlađih od 18 godina).
English: Warning: Prevent the pen needle from bending or breaking.
Croatian: Upozorenje: Pazite da se igla ne savije ili slomi.
English: Therefore, if blood samples for serum calcium measurements are taken, this should be done at least 16 hours after the most recent teriparatide injection.
Croatian: Stoga, ako se bolesniku uzima uzorak krvi radi mjerenja koncentracije kalcija u serumu, to treba učiniti najmanje 16 sati nakon posljednje injekcije teriparatida.
English: Setting the dose and injection”.
Croatian: Namještanje doze i injiciranje'.
English: Note for healthcare professionals
Croatian: Napomena za zdravstvene radnike
English: - Metabolic bone diseases (including hyperparathyroidism and Paget's disease of the bone) other than primary osteoporosis or glucocorticoid-induced osteoporosis.
Croatian: - Metaboličke bolesti kostiju (uključujući hiperparatireoidizam te Pagetovu bolest kostiju) osim primarne osteoporoze ili osteoporoze izazvane glukokortikoidima.
English: D: Push back the threaded rod carefully with your finger, in a straight line and as far as it will go.
Croatian: D: Prstom pažljivo gurnite potisnik s navojem, ravno, koliko god ide.
English: Use a new needle for every injection.
Croatian: Upotrijebite novu iglu za svaku injekciju.
English: In post-marketing spontaneous reports, there have been cases of medication error where the entire contents (up to 800 micrograms) of a teriparatide pen have been administered as a single dose.
Croatian: U spontanim prijavama nakon stavljanja lijeka u promet navode se slučajevi pogrešaka u primjeni lijeka, kada je cjelokupan sadržaj (do 800 mikrograma) brizgalice s teriparatidom primijenjen u jednoj dozi.
English: Pregnancy Terrosa is contraindicated for use during pregnancy (see section 4.3).
Croatian: Trudnoća Primjena lijeka Terrosa kontraindicirana je tijekom trudnoće (vidjeti dio 4.3).
English: (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), and rare (≥1/10,000 to
Croatian: < 1/10), manje često (≥ 1/1000 i < 1/100) i rijetko (≥ 1/10 000 i < 1/1000).
English: Never immerse the Terrosa Pen in water, as this could damage the pen.
Croatian: Nikada nemojte brizgalicu Terrosa Pen uranjati u vodu jer biste je mogli oštetiti.
English: There were no important effects observed in pregnant rats or mice administered teriparatide at daily doses of 30 to 1000 micrograms/kg.
Croatian: Nisu opaženi važni učinci u skotnih ženki štakora ili miševa koji su primali teriparatid u dnevnim dozama od 30 do 1000 mikrograma/kg.
English: This helps you to know when the 28 daily doses per cartridge are used.
Croatian: Tako ćete znati kada je potrošeno 28 dnevnih doza sadržanih u jednom ulošku.
English: In postmenopausal women, a significant reduction in the incidence of vertebral and non-vertebral fractures but not hip fractures has been demonstrated.
Croatian: U postmenopauzalnih žena dokazano je značajno smanjenje incidencije vertebralnih i nevertebralnih prijeloma, no ne i prijeloma kuka.
English: • the pen being used with a medical device, accessories or consumables other than those recommended by Gedeon Richter Plc.
Croatian: • korištenjem brizgalice zajedno s medicinskim proizvodima, pomoćnim priborom ili potrošnim materijalima koje ne preporučuje Gedeon Richter Plc.
English: The 24-month course of teriparatide should not be repeated over a patient's lifetime.
Croatian: 24mjesečni ciklus liječenja teriparatidom ne smije se ponoviti tijekom života bolesnika.
English: Avoid placing the cartridge close to the ice compartment of the refrigerator to prevent freezing.
Croatian: Pazite da uložak ne stavljate blizu zamrzivača u hladnjaku da se ne bi zamrznuo.
English: *Teriparatide, rhPTH(1-34), produced in E. coli, using recombinant DNA technology, is identical to the 34-N-terminal amino acid sequence of endogenous human parathyroid hormone.
Croatian: *Teriparatid, rhPTH(1-34), koji je proizveden u E. coli tehnologijom rekombinantne DNK, istovjetan je sekvenci 34 N-terminalne aminokiseline endogenog humanog paratiroidnog hormona.
English: Insert the needle straight and gently into the skin, as shown in the illustration.
Croatian: Nježno ubodite iglu ravno u kožu, kao što je prikazano na slici.
English: If you are considering stopping Terrosa treatment, please discuss this with your doctor.
Croatian: Ako razmišljate o prekidu liječenja lijekom Terrosa, razgovarajte o tome sa svojim liječnikom.
English: If the display still does not return to start position after injection, do not use this pen; contact customer service.
Croatian: Ako se prozorčić ponovno ne vrati u početni položaj nakon injekcije, nemojte koristiti brizgalicu; obratite se službi za korisnike.
English: Post-treatment management: Following treatment with teriparatide, 1,262 postmenopausal women from the pivotal trial enrolled in a post-treatment follow-up study.
Croatian: Praćenje nakon liječenja: Po završetku liječenja teriparatidom su 1262 žene u postmenopauzi koje su sudjelovale u pivotalnom ispitivanju uključene u ispitivanje praćenja nakon liječenja.
English: Before using the pen device for the first time, the patient should read and understand the instructions on how to use the pen which are provided with the pen.
Croatian: Prije primjene brizgalice po prvi put, bolesnik mora pročitati i razumjeti upute o korištenju brizgalice koje su priložene uz brizgalicu.
English: • heartburn (painful or burning sensation just below the breast bone)
Croatian: • žgaravica (bol ili pečenje neposredno ispod prsne kosti)
English: Use another needle instead.
Croatian: Upotrijebite drugu iglu.
English: Teriparatide has been administered in single doses of up to 100 micrograms and in repeated doses of up to 60 micrograms/day for 6 weeks.
Croatian: Teriparatid se primjenjivao u jednokratnim dozama do 100 mikrograma i višekratnim dozama do 60 mikrograma na dan tijekom 6 tjedana.
English: Injecting Terrosa - Before you inject Terrosa, clean your skin where you intend to inject (thigh or abdomen) as instructed by your doctor.
Croatian: - Prije nego injektirate lijek Terrosa, očistite kožu na mjestu gdje namjeravate injektirati (bedro ili trbuh) prema uputama Vašeg liječnika.
English: Make sure the display shows an arrow sign and the two indicator stripes are aligned.
Croatian: Uvjerite se da je u prozorčiću prikazan znak strelice i da su dvije pokazne linije poravnate.
English: For the first doses, inject Terrosa in a place where you can sit or lie down right away if you get dizzy.
Croatian: Prve injekcije lijeka Terrosa primijenite na mjestu gdje možete odmah sjesti ili leći ako osjetite omaglicu.
English: 680 subjects were randomised to teriparatide and 680 subjects were randomised to oral risedronate 35 mg/week.
Croatian: 680 ispitanica bilo je randomizirano za primanje teriparatida, a 680 za liječenje peroralnim risedronatom u dozi od 35 mg na tjedan.
English: You can use Terrosa for up to 28 days after the first injection, as long as the cartridge/pen with the cartridge inserted is stored in a refrigerator (2 °C to 8 °C).
Croatian: Terrosa se može primjenjivati najdulje 28 dana nakon prve injekcije ako se uložak/brizgalica s umetnutim uloškom čuva u hladnjaku (2°C do 8°C).
English: Before the first use, insert the cartridge into the pen.
Croatian: Prije prve uporabe, stavite uložak u brizgalicu.
English: You should inject Terrosa shortly after you take the pen with inserted cartridge out of the refrigerator.
Croatian: Lijek Terrosa trebate injektirati ubrzo nakon što ste brizgalicu s umetnutim uloškom izvadili iz hladnjaka.
English: Do not tilt the pen after the needle has been inserted into the skin.
Croatian: Nemojte naginjati brizgalicu nakon što iglu ubodete u kožu.
English: • Do not remove the cartridge from the Terrosa Pen before it is empty.
Croatian: • Nemojte vaditi uložak iz brizgalice Terrosa Pen sve dok se ne isprazni.
English: Teriparatide has not been studied in patients with active urolithiasis.
Croatian: Teriparatid nije ispitivan u bolesnika s aktivnom urolitijazom.
English: Subcutaneous use {1x} SC
Croatian: Za potkožnu primjenu {1x} s.c.
English: Of patients in the teriparatide trials, 82.8% of the teriparatide patients and 84.5% of the placebo patients reported at least 1 adverse event.
Croatian: U ispitivanjima teriparatida je 82,8% bolesnika koji su primali teriparatid i 84,5% bolesnika koji su primali placebo prijavilo barem jedan štetan događaj.
English: Teriparatide may cause small increases in urinary calcium excretion, but the incidence of hypercalciuria did not differ from that in the placebo-treated patients in clinical trials.
Croatian: Teriparatid može malo povećati izlučivanje kalcija mokraćom, no incidencija hiperkalciurije nije se razlikovala od one u bolesnika koji su tijekom kliničkih ispitivanja primali placebo.
English: Following cessation of teriparatide therapy, patients may be continued on other osteoporosis therapies.
Croatian: Nakon završetka terapije teriparatidom bolesnici smiju nastaviti liječenje osteoporoze drugim lijekovima.
English: The recommended dose is 20 micrograms (corresponding to 80 microliters) given once a day by injection under the skin (subcutaneous injection) in the thigh or abdomen.
Croatian: Preporučena doza je 20 mikrograma (što odgovara 80 mikrolitara) jedanput na dan, a primjenjuje se injekcijom pod kožu (supkutanom injekcijom) u bedro ili trbuh.
English: - Pre-existing hypercalcaemia.
Croatian: - Postojeća hiperkalcijemija.
English: Method of administration Terrosa should be administered once daily by subcutaneous injection in the thigh or abdomen.
Croatian: Terrosa se primjenjuje jedanput dnevno supkutanom injekcijom u bedro ili abdomen.
English: • a puncture-resistant sharps disposal container for used needles.
Croatian: • neprobojan spremnik za odlaganje oštrih predmeta za iskorištene igle
English: In an open-label study, 503 postmenopausal women with severe osteoporosis and a fragility fracture within the previous 3 years (83% had received previous osteoporosis therapy) were treated with teriparatide for up to 24 months.
Croatian: U otvorenom su ispitivanju 503 postmenopauzalne žene s teškom osteoporozom i prijelomima zbog krhkosti u prethodne 3 godine (83% ih je već bilo liječeno zbog osteoporoze) liječene teriparatidom najdulje 24 mjeseca.
English: Note: If the cartridge contains less than 80 microliters, the dose knob cannot be turned clockwise up to the arrow sign.
Croatian: Napomena: Ako uložak sadrži manje od 80 mikrolitara lijeka, kotačić za doziranje ne može se okrenuti u smjeru kazaljke na satu sve do prikaza znaka strelice.
English: Rats treated with near-life time daily injections had dose-dependent exaggerated bone formation and increased incidence of osteosarcoma most probably due to an epigenetic mechanism.
Croatian: Štakori koji su gotovo čitavog života svakodnevno primali injekcije imali su o dozi ovisnu, pojačanu formaciju kosti i povećanu incidenciju osteosarkoma, najvjerojatnije zbog epigenetičkog mehanizma.
English: From a microbiological point of view, once opened, the product may be stored for a maximum of 28 days within its shelf life at 2 °C to 8 °C.
Croatian: S mikrobiološkog aspekta, nakon otvaranja, lijek se može čuvati najdulje 28 dana unutar navedenog roka valjanosti, na temperaturi od 2°C do 8°C.
English: • if you have ever had bone cancer or if other cancers have spread (metastasised) to your bones.
Croatian: ako ste ikada imali rak kosti ili su se neke druge vrste raka proširile (metastazirale) u kosti. ako bolujete od određenih bolesti kostiju.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS LID FOIL
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP FOLIJA POKLOPCA
English: In a large clinical trial, antibodies that cross-reacted with teriparatide were detected in 2.8% of women receiving teriparatide.
Croatian: U velikom kliničkom ispitivanju su protutijela koja su ukriženo reagirala s teriparatidom utvrđena u 2,8% žena koje su primale teriparatid.
English: In addition, 15 of 214 patients in the alendronate group (7.0%) had experienced a non-vertebral fracture compared with 16 of 214 patients in the teriparatide group (7.5%) (p=0.84).
Croatian: Nadalje, nevertebralni prijelom je imalo 15 od 214 bolesnika iz skupine liječene alendronatom (7,0%) u usporedbi sa 16 od 214 bolesnika iz skupine koja je primala teriparatid (7,5%) (p = 0,84).
English: • Ypsomed mylifeClickfine 29 to 31 gauge (diameter 0.25 - 0.33 mm) and 12, 10, 8 or 6 mm length
Croatian: • Ypsomed mylife Clickfine veličine 29 - 31 G (promjera 0,25 - 0,33 mm) i duljine 12, 10, 8 ili 6 mm
English: The efficacy of teriparatide in men and women (N=428) receiving sustained systemic glucocorticoid therapy (equivalent to 5 mg or greater of prednisone for at least 3 months) was demonstrated in the 18month primary phase of a 36-month, randomised, double-blind, comparator-controlled study (alendronate 10 mg/day).
Croatian: Djelotvornost teriparatida u muškaraca i žena (N=428) dugotrajno liječenih sistemskim glukokortikoidima (ekvivalentno dozi prednizona od 5 mg ili više tijekom najmanje 3 mjeseca) dokazana je u 18-mjesečnoj primarnoj fazi 36-mjesečnog, randomiziranog, dvostruko slijepog,
English: Dispose of it correctly, for example, in a puncture-resistant sharps disposal container.
Croatian: Zbrinite je na odgovarajući način, primjerice u neprobojan spremnik za odlaganje oštrih predmeta.
English: Discard the cartridge 28 days after the first use.
Croatian: Baciti uložak 28 dana nakon prve primjene.
English: Elderly Dosage adjustment based on age is not required (see section 5.2).
Croatian: Nije potrebno prilagođavati dozu s obzirom na dob (vidjeti dio 5.2).
English: Because teriparatide transiently increases serum calcium, teriparatide should be used with caution in patients taking digitalis.
Croatian: S obzirom na to da teriparatid prolazno povećava koncentraciju kalcija u serumu, treba ga primjenjivati uz oprez u bolesnika koji uzimaju digitalis.
English: Instructions for use Terrosa Pen
Croatian: Upute za uporabu Terrosa Pen
English: The pen and injection needles are not included with Terrosa.
Croatian: Brizgalica i igle za injekciju nisu uključene u pakiranju lijeka Terrosa.
English: Richter-Helm BioLogics GmbH & Co. KG Dengelsberg
Croatian: Richter-Helm BioLogics GmbH & Co.
English: - As soon as you have finished the injection, attach the outer needle protective cap on the pen needle and screw the cap anti-clockwise to remove the pen needle.
Croatian: - Čim ste završili injektiranje, stavite vanjsku zaštitnu kapicu na iglu brizgalice i okrećući suprotno od kazaljke na satu uklonite iglu s brizgalice.
English: These are listed in the instruction for use for the pen.
Croatian: One su navedene u uputama za uporabu brizgalice.
English: The warranty covers manufacturing and material defects of your Terrosa Pen for two years of use, from purchase.
Croatian: Jamstvo Jamstvo pokriva proizvodne i fizičke nedostatke na brizgalici Terrosa Pen tijekom dvije godine nakon kupovine i ograničeno je na zamjenu brizgalice.
English: • Store your Terrosa Pen, cartridges and pen needles out of reach of children.
Croatian: • Čuvajte brizgalicu Terrosa Pen, uloške i igle izvan dohvata djece.
English: In clinical trials the following reactions were reported at a ≥1% difference in frequency from placebo: vertigo, nausea, pain in limb, dizziness, depression, dyspnoea.
Croatian: U kliničkim su ispitivanjima sljedeće nuspojave zabilježene uz razliku učestalosti od ≥ 1% kod primjene teriparatida u odnosu na placebo: vrtoglavica, mučnina, bol u udovima, omaglica, depresija,
English: Organ System Class
Croatian: Klasifikacija organskih sustava
English: Co-administration of raloxifene or hormone replacement therapy with teriparatide did not alter the effects of teriparatide on serum or urine calcium or on clinical adverse events.
Croatian: Istodobna primjena raloksifena ili hormonske nadomjesne terapije i teriparatida nije promijenila učinke teriparatida na koncentraciju kalcija u serumu ili mokraći niti na kliničke nuspojave.
English: Pharmacotherapeutic group: Calcium homeostasis, parathyroid hormones and analogues, ATC code: H05AA02
Croatian: Farmakoterapijska skupina: Pripravci s utjecajem na mijenu kalcija, paratiroidni hormoni i njihovi analozi, ATK oznaka: H05AA02.
English: An instruction for use which is included in the carton of the delivery system is also available to instruct patients on the correct use of the pen.
Croatian: Postoje i upute za uporabu koje su priložene u kutiji sustava za isporuku lijeka s uputama za pravilno korištenje brizgalice.
English: Do not use this medicine after the expiry date which is stated on the carton and the cartridge after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i ulošku iza oznake „Rok valjanosti” i „EXP”.
English: B: Remove the cartridge holder by turning it (bayonet coupling).
Croatian: B: Zakrenite i odvojite držač uloška (bajunetni spoj).
English: Terrosa should not be used if the solution is cloudy, coloured or contains visible particles.
Croatian: Terrosa se ne smije primijeniti ako je otopina zamućena, obojana ili sadrži vidljive čestice.
English: - After inserting a new cartridge and before the first injection from this cartridge prime the pen according to the instructions which are provided.
Croatian: Nakon stavljanja novog uloška i prije prve injekcije iz tog uloška pripremite brizgalicu u skladu s priloženim uputama.
English: Terrosa must not be transferred to a syringe.
Croatian: Terrosa se ne smije prebacivati u štrcaljku.
English: Do not drop your pen and avoid knocking it against hard surfaces.
Croatian: Pazite da Vam brizgalica ne padne i da njome ne udarite o tvrdu površinu.
English: If you forget to use Terrosa
Croatian: Ako ste zaboravili primijeniti lijek Terrosa
English: To prevent one or more new vertebral fractures, 11 women had to be treated for a median of 19 months.
Croatian: 11 žena je trebalo liječiti tijekom medijana od 19 mjeseci.
English: - Prior external beam or implant radiation therapy to the skeleton.
Croatian: - Prethodna teleradioterapija ili brahiradioterapija skeleta.
English: After the first use, the cartridge should not be removed from the pen during the 28 days of usage.
Croatian: Nakon prve primjene, uložak ne treba uklanjati s brizgalice tijekom 28 dana primjene.