FrancophonIA/ELRC3.0 huggingface dataset:
English: The likelihood of metabolic substance interactions with lamivudine is low due to the small (5-10 %) extent of hepatic metabolism and the low plasma protein binding.
Croatian: Vjerojatnost metaboličke interakcije s drugim lijekovima je mala budući da se lamivudin malim dijelom metabolizira u jetri (5-10 %) i slabo veže na proteine plazme.
English: When doses below 100 mg are required Zeffix oral solution should be used (see Table 1 below).
Croatian: U slučaju da su potrebne doze manje od 100 mg, preporuča se primjena Zeffix oralne otopine radi lakšeg doziranja (vidjeti Tablicu 1).
English: If you forget to take Zeffix
Croatian: Ako ste zaboravili uzeti Zeffix
English: Slowly push the plunger in, allowing time to swallow.
Croatian: Polako pritisnite klip kako bi si dali dovoljno vremena da progutate lijek.
English: 15 to < 30
Croatian: 15 do <30
English: Lamivudine has been administered to children (2 years and above) and adolescents with compensated chronic hepatitis B. However, due to limitations of the data, the administration of lamivudine to this patient population is not currently recommended (see section 5.1).
Croatian: Pedijatrijski bolesnici Lamivudin je primjenjivan u djece (u dobi od 2 godine i više) i adolescenata s kompenziranim kroničnim hepatitisom B. Međutim, zbog ograničenih podataka zasad se ne preporučuje primjena lamivudina u toj populaciji bolesnika (vidjeti dio 5.1).
English: • In patients with decompensated liver disease or cirrhosis and in liver transplant recipients, treatment cessation is not recommended (see section 5.1).
Croatian: • U bolesnika s dekompenziranom bolešću jetre, cirozom jetre i bolesnika s transplantiranom jetrom, ne preporučuje se prestanak liječenja (vidjeti dio 5.1).
English: Normalisation of ALT levels occurred in 31 % (14/45) of patients receiving combined therapy versus 6 % (3/47) receiving lamivudine alone.
Croatian: Normalizacija razina ALT-a nastupila je u 31% (14/45) bolesnika koji su primali kombiniranu terapiju u odnosu na 6% (3/47) bolesnika koji su primali samo lamivudin.
English: Where there is maternal transmission of HBV, despite adequate prophylaxis, consideration should be given to discontinuing breastfeeding to reduce the risk of the emergence of lamivudine resistant mutants in the infant.
Croatian: U slučaju prijenosa HBV-a s majke na dijete unatoč primjerenoj profilaksi, treba razmotriti prekid dojenja kako bi se smanjio rizik pojave varijanti virusa rezistentnih na lamivudin u dojenčeta.
English: The oral solution contains propyl and methyl parahydroxybenzoate.
Croatian: Oralna otopina sadrži propil i metilparahidroksibenzoat.
English: The tablets are butterscotch coloured, capsule shaped, biconvex and engraved “GX CG5” on one side.
Croatian: Tablete su svijetlosmeđe boje, oblika kapsule, bikonveksne, s utisnutom oznakom „GX CG5“ na jednoj strani.
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays low plasma protein binding to albumin.
Croatian: Lamivudin pokazuje linearnu farmakokinetiku unutar terapijskih doza i nisko vezanje na proteine plazme (albumini).
English: The solution is clear, colourless to pale yellow in colour with strawberry/banana flavouring.
Croatian: Otopina je bistra, bezbojna do blijedožute boje s okusom jagode i banane.
English: Exacerbations after treatment discontinuation
Croatian: Egzacerbacije nakon prekida liječenja
English: YMDD mutant HBV status
Croatian: Razvoj YMDD mutiranog HBV
English: Patients should be advised that therapy with lamivudine has not been proven to reduce the risk of transmission of hepatitis B virus to others and therefore, appropriate precautions should still be taken.
Croatian: Bolesnike treba upozoriti da nije dokazano da liječenje lamivudinom smanjuje rizik od prijenosa HBV-a na druge osobe te da i dalje moraju primjenjivati odgovarajuće mjere opreza.
English: However, unless the patient has renal impairment, no dosage adjustment of lamivudine is necessary.
Croatian: Međutim, osim u slučaju oštećenja bubrega, nije potrebno prilagođavati dozu lamivudina.
English: Since lamivudine is dialysable, continuous haemodialysis could be used in the treatment of overdose, although this has not been studied.
Croatian: Budući da se lamivudin može odstraniti dijalizom, pri liječenju predoziranja može se koristiti kontinuirana hemodijaliza, iako nisu provedena ispitivanja.
English: The active ingredient in Zeffix is lamivudine.
Croatian: Djelatna tvar u lijeku Zeffix je lamivudin.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu/
English: • skin rash or ‘hives' anywhere on the body
Croatian: • grčevi i bolovi u mišićima • kožni osip ili “koprivnjača” bilo gdje na tijelu
English: The pack also includes a polyethylene applicator-adapter, and a 10 ml oral applicator comprised of a polypropylene barrel (with ml graduations) and a polyethylene plunger.
Croatian: Pakiranje također sadrži polietilenski nastavak za aplikator i aplikator od 10 ml za peroralnu primjenu, koji se sastoji od polipropilenske cijevi (s oznakama za ml) i polietilenskog klipa.
English: However, the proportion of patients who had post-treatment elevations associated with bilirubin elevations was low and similar in both treatment arms (see Table 3 in section 5.1).
Croatian: Međutim, udio bolesnika u kojih je porast razina ALT nakon liječenja bio udružen s porastom bilirubina bio je nizak i sličan u obje skupine u studiji (vidjeti Tablicu 3 u dijelu 5.1 ).
English: Reproductive studies in animals have shown no effect on male or female fertility (see section 5.3).
Croatian: Ispitivanja reprodukcije na životinjama nisu pokazala učinke na plodnost mužjaka ni ženki (vidjeti dio 5.3).
English: Any child exposed in utero to nucleoside and nucleotide analogues, should have clinical and laboratory follow-up and should be fully investigated for possible mitochondrial dysfunction in cases which have relevant signs or symptoms.
Croatian: Svako dijete koje je in utero bilo izloženo analozima nukleozida i nukleotida treba pratiti laboratorijskim pretragama i klinički, a u slučaju relevantnih znakova ili simptoma treba pomno ispitati mogućnost disfunkcije mitohondrija.
English: Clear, colourless to pale yellow in colour.
Croatian: Oralna otopina Bistra, bezbojna do blijedo žute boje.
English: • a worsening of liver disease after Zeffix is stopped or during treatment if the hepatitis B virus becomes resistant to Zeffix.
Croatian: • pogoršanje jetrene bolesti nakon prekida liječenja lijekom Zeffix ili tijekom terapije u slučaju pojave rezistencije na Zeffix.
English: The active substance is lamivudine.
Croatian: Djelatna tvar je lamivudin.
English: • emtricitabine, used to treat HIV or hepatitis B infection
Croatian: • emtricitabin, koji se primjenjuju za liječenje infekcija HIV-om ili hepatitisom B
English: Serum ALT and HBV DNA levels should be monitored at 3 month intervals and in HBeAg positive patients HBeAg should be assessed every 6 months.
Croatian: Serumske razine ALT i HBV DNK treba kontrolirati svaka 3 mjeseca, a u HbeAg pozitivnih bolesnika HbeAg treba odrediti svakih 6 mjeseci.
English: Talk to your doctor if this applies to you.
Croatian: Razgovarajte sa svojim liječnikom ako se ovo odnosi na Vas.
English: Therefore, following HBeAg seroconversion, patients should be periodically monitored to determine that serologic and clinical responses are being maintained.
Croatian: Stoga, nakon serokonverzije HBeAg bolesnike treba periodički pratiti kako bi se utvrdilo je li održan serološki i klinički odgovor.
English: The mean systemic clearance of lamivudine is approximately 0.3 l/h/kg.
Croatian: Srednja vrijednost sistemskog klirensa lamivudina je približno 0,3 l/h/kg.
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breastfed infants of mothers treated for HIV are very low (less than 4% of maternal serum concentrations) and progressively decrease to undetectable levels when breastfed infants reach 24 weeks of age.
Croatian: Temeljem analize više od 200 parova majka/dijete liječenih zbog HIV-a, serumske koncentracije lamivudina u djece dojene od majki liječenih zbog HIV-a vrlo su niske (manje od 4% serumskih koncentracija kod majke) i progresivno padaju do nemjerljivih razina kad dojenčad dosegne 24 tjedna starosti.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON FOR TABLETS: 28 tablet box, 84 tablet box
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKA KUTIJA ZA TABLETE: kutija s 28 tableta, kutija s 84 tableta
English: In the controlled Phase III trials with no-active-treatment follow-up, the incidence of post-treatment ALT elevations (more than 3 times baseline) was higher in lamivudine-treated patients (21%) compared with those receiving placebo (8%).
Croatian: U fazi III kontroliranih ispitivanja. u kojima su praćeni bolesnici bez aktivnog liječenja incidencija porasta razina ALT nakon liječenja (više nego trostruko od početne razine) bila je veća u bolesnika koji su bili liječeni lamivudinom (21%) nego u onih koji su bili dobivali placebo (8%).
English: Lamivudine has no pharmacokinetic interaction with alpha-interferon when the two medicinal products are concurrently administered.
Croatian: Lamivudin ne ulazi u farmakokinetičke interakcije s alfa-interferonom prilikom istovremene primjene ta dva lijeka.
English: The pack includes an oral applicator with ml graduations and an applicator-adapter, which should be fitted to the bottle before use.
Croatian: Pakiranje također sadrži aplikator za primjenu kroz usta s oznakama u mililitrima (ml) i nastavak za aplikator koji treba pričvrstiti na bocu prije primjene.
English: Data available in patients undergoing intermittent haemodialysis (for less than or equal to 4 hrs dialysis 2-3 times weekly), indicate that following the initial dosage reduction of lamivudine to correct for the patient's creatinine clearance, no further dosage adjustments are required while undergoing dialysis.
Croatian: Podaci o bolesnicima na intermitentnoj hemodijalizi (4 sata dijalize ili manje, 2-3 puta na tjedan) pokazuju da nakon početnog smanjenja doze lamivudina radi klirensa kreatinina nije potrebno daljnje prilagođavanje doze za vrijeme dijalize.
English: Cartons containing 240 ml lamivudine oral solution in an opaque, white, high-density polyethylene (HDPE) bottle with a polypropylene child resistant closure.
Croatian: Kutija sadrži 240 ml oralne otopine lamivudina u neprozirnoj, bijeloj boci od polietilena visoke gustoće (HDPE) sa polipropilenskim sigurnosnim zatvaračem za djecu.
English: 10 Close the bottle tightly with the cap.
Croatian: Zatvaračem čvrsto zatvorite bocu.
English: The bottle contains 240 ml of lamivudine solution (5 mg/ml).
Croatian: Boca sadrži 240 ml otopine lamivudina (5 mg/ml).
English: Maternal hepatitis B is not a contraindication to breast-feeding if the newborn is adequately managed for hepatitis B prevention at birth, and there is no evidence that the low concentration of lamivudine in human milk leads to adverse reactions in breastfed infants.
Croatian: Hepatitis B kod majke nije kontraindikacija za dojenje ako je prilikom rođenja provedena primjerena prevencija hepatitisa B kod novorođenčeta i nema dokaza da niska koncentracija lamivudina u humanom mlijeku dovodi do nuspojava u dojenčeta.
English: - Baseline normal above normal
Croatian: - početne vrijednosti normalne više od normalnih
English: Renal clearance accounts for about 70 % of lamivudine elimination.
Croatian: Bubrežnim klirensom eliminira se oko 70% lamivudina.
English: - Week 260 4 negative positive < baseline positive > baseline
Croatian: - 260. tjedan4 negativne pozitivne < početnih pozitivne > početnih
English: Data is available from an extended treatment study in HBeAg negative patients (NUCAB3017) treated with lamivudine.
Croatian: Dostupni su podaci iz ispitivanja produljenog liječenja HbeAg negativnih bolesnika (NUCAB3017) liječenih lamivudinom.
English: Continued lamivudine treatment for an additional 2 years in patients who had failed to achieve HBeAg seroconversion in the initial 1 year controlled studies resulted in further improvement in bridging fibrosis.
Croatian: Nastavak liječenja lamivudinom tijekom daljnje 2 godine u bolesnika u kojih nije došlo do serokonverzije HBeAg u inicijalnim jednogodišnjim kontroliranim ispitivanjima doveo je do daljnjeg poboljšanja premoštavajuće fibroze.
English: 100 mg once daily, Cmax is in the order of 1.1-1.5 µg/ml and trough levels were 0.015-0.020 µg/ml.
Croatian: Pri terapijskim dozama, npr. 100 mg jedanput na dan, Cmax se kreće u vrijednostima od 1,1 do 1,5 µg/ml dok su najniže koncentracije lijeka 0,015-0,020 µg/ml.
English: Table 1: Dosage of Zeffix in patients with decreased renal clearance.
Croatian: Tablica 1: Doziranje lijeka Zeffix za bolesnike sa smanjenim bubrežnim klirensom
English: Following HBeAg seroconversion, serologic response and clinical remission are generally durable after stopping lamivudine.
Croatian: Nakon serokonverzije HbeAg, serološki odgovor i klinička remisija općenito traju i nakon prestanka uzimanja lamivudina.
English: Allergic reaction These are rare (may affect up to 1 in 1,000 people).
Croatian: One su rijetke (mogu se javiti u do 1 na 1000 osoba).
English: A comparison of post-treatment ALT elevations between weeks 52 and 68 in patients who discontinued lamivudine at week 52 and patients in the same studies who received placebo throughout the treatment course is shown in Table 3.
Croatian: Usporedba porasta razina ALT nakon liječenja, između 52. i 68. tjedna, u bolesnika koji su prestali uzimati lamivudin u 52. tjednu i bolesnika iz istih ispitivanja koji su dobivali placebo tijekom razdoblja liječenja prikazana je u Tablici
English: In patients who do not maintain a sustained serological response, consideration should be given to retreatment with either lamivudine or an alternative antiviral agent for resumption of clinical control of HBV.
Croatian: U bolesnika u kojih se ne održi serološki odgovor, treba razmotriti ponovno uvođenje lamivudina ili nekog drugog protuvirusnog lijeka u cilju ponovnog uspostavljanja kliničke kontrole HBV-a.
English: Side effects that were commonly reported in Zeffix clinical trials were tiredness, respiratory tract infections, throat discomfort, headache, stomach discomfort and pain, nausea, vomiting and diarrhoea, increases in liver enzymes and enzymes produced in the muscles (see below).
Croatian: Nuspojave koje su često zabilježene u kliničkim ispitivanjima s lijekom Zeffix bile su umor, infekcije dišnih puteva, neugoda u grlu, glavobolja, neugoda i bol u želucu, mučnina, povraćanje i proljev, povišene vrijednosti jetrenih enzima i enzima koje proizvode mišići (pogledajte tekst ispod).
English: The standard recommended procedures for hepatitis B virus immunisation in infants should be followed.
Croatian: Treba slijediti standardne preporuke za imunizaciju djece protiv hepatitisa B.
English: Improvement in bridging fibrosis occurred in 19/30 (63 %) patients without YMDD mutant and 22/44 (50 %) patients with the mutant.
Croatian: Poboljšanje premoštavajuće fibroze nastupilo je u 19/30 (63 %) bolesnika bez YMDD tipa virusa i 22/44 (50 %) bolesnika s YMDD tipom virusa.
English: Substances shown to be predominately excreted either via the active organic anionic pathway, or by glomerular filtration are unlikely to yield clinically significant interactions with lamivudine.
Croatian: Mala je vjerojatnost da bi tvari koje se pretežno izlučuju aktivnim organskim anionskim putem ili glomerularnom filtracijom doprinijele klinički značajnim interakcijama s lamivudinom.
English: There have been reports of mitochondrial dysfunction in infants exposed in utero and/or post-natally to nucleoside analogues (see section 4.4).
Croatian: Također postoje izvješća o disfunkciji mitohondrija u djece izložene nukleozidnim analozima in utero i/ili postnatalno (vidjeti dio 4.4).
English: Based on these data, no dose adjustment is necessary in patients with hepatic impairment unless accompanied by renal impairment.
Croatian: Temeljem tih podataka, nije potrebno prilagođavati dozu u bolesnika s oštećenjem jetre osim ako ono nije udruženo s oštećenjem bubrega.
English: Zeffix oral solution is supplied in cartons containing a white polyethylene bottle, with a child resistant cap.
Croatian: Zeffix oralna otopina dolazi u kutiji koja sadrži bijelu polietilensku bocu sa sigurnosnim zatvaračem za djecu.
English: Lamivudine had no effect on the pharmacokinetics of trimethoprim or sulphamethoxazole.
Croatian: Lamivudin ne utječe na farmakokinetiku trimetoprima ili sulfametoksazola.
English: Lamivudine is predominately cleared by renal excretion of unchanged substance.
Croatian: Lamivudin se pretežno izlučuje renalnim izlučivanjem nepromijenjenog lijeka.
English: Butterscotch coloured, film-coated, capsule shaped, biconvex, approximate dimensions 11mm x 5mm and engraved “GX CG5” on one face.
Croatian: Svijetlosmeđa, bikonveksna, filmom obložena tableta oblika kapsule, dimenzija približno 11 mm x 5 mm, s utisnutom oznakom “GX CG5” na jednoj strani.
English: Don't stop taking Zeffix
Croatian: Nemojte prestati uzimati Zeffix
English: Zeffix film-coated tablets are supplied in tamper evident foil blisters containing 28 or 84 tablets.
Croatian: Zeffix filmom obložene tablete su dostupne u blister pakiranju s evidencijom prvog otvaranja koji sadrži 28 ili 84 tablete.
English: In patients followed for up to 16 weeks after discontinuation of treatment at one year, post-treatment ALT elevations were observed more frequently in patients who had received lamivudine than in patients who had received placebo.
Croatian: U bolesnika praćenih do 16 tjedana nakon prestanka jednogodišnjeg liječenja porast razina ALT nakon liječenja češće je zabilježen u bolesnika koji su dobivali lamivudin nego u onih koji su dobivali placebo.
English: The main adverse events reported are haematological disorders (anaemia, neutropenia), metabolic disorders (hyperlipasemia).
Croatian: Najčešće prijavljene nuspojave su hematološki poremećaji (anemija, neutropenija) i metabolički poremećaji (povišena razina lipaza).
English: Zidovudine had no effect on the pharmacokinetics of lamivudine (see section 5.2).
Croatian: Zidovudin ne utječe na farmakokinetiku lamivudina (vidjeti dio 5.2).
English: As anticipated due to the concomitant immunosuppression, the rate of emergence of YMDD mutant HBV after 52 weeks treatment was higher (36 % - 64 %) in the liver transplant population than in the immunocompetent CHB patients (14 % - 32 %).
Croatian: Kako se i očekivalo, zbog istodobne imunosupresije, stopa pojave YMDD tipa virusa nakon 52 tjedna bila je veća u bolesnika s transplantiranom jetrom (36%-64%) nego u imunokompetentnih bolesnika s kroničnim hepatitisom B (14%-32%).
English: Exacerbations in patients with decompensated cirrhosis Transplantation recipients and patients with decompensated cirrhosis are at greater risk from active viral replication.
Croatian: Primatelji transplantiranih organa i bolesnici s dekompenziranom cirozom pod većim su rizikom od aktivne replikacije virusa.
English: Furthermore, lamivudine-TP has little effect on mammalian cell DNA content.
Croatian: Nadalje, lamivudin-trifosfat ima mali učinak na sadržaj DNK u stanicama sisavaca.
English: Glaxo Operations UK Limited (trading as Glaxo Wellcome Operations) Harmire Road
Croatian: Glaxo Operations UK Limited (posluje kao Glaxo Wellcome Operations) Harmire Road
English: compensated liver disease with evidence of active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active liver inflammation and/or fibrosis.
Croatian: • kompenziranom bolešću jetre i dokazanom aktivnom replikacijom virusa, trajno povišenim razinama alanin aminotransferaze (ALT) u serumu i histološki dokazanom aktivnom upalom jetre i/ili fibrozom.
English: Moreover, Zeffix should not be taken with any other medicinal products containing lamivudine (see section 4.4).
Croatian: Osim toga, Zeffix se ne smije uzimati s drugim lijekovima koji sadrže lamivudin (vidjeti dio 4.4).
English: Given the risk of YMDD mutant HBV, maintenance of lamivudine monotherapy is not appropriate in patients with detectable serum HBV DNA at or beyond 24 weeks of treatment (see section 4.4).
Croatian: S obzirom na rizik od YMDD mutiranog virusa HBV, održavanje monoterapije lamivudinom nije primjereno u bolesnika s detektabilnim HBV DNK u serumu nakon 24 tjedna liječenja ili dulje od toga (vidjeti dio 4.4).
English: Sucrose 20 % w/v (4 g/20 ml) Methyl parahydroxybenzoate (E218) 1.5 mg/ml Propyl parahydroxybenzoate (E216) 0.18 mg/ml
Croatian: saharoza 20 % m/V (4 g/20 ml) metilparahidroksibenzoat (E218) 1,5 mg/ml propilparahidroksibenzoat (E216) 0,18 mg/ml
English: This population primarily consisted of children with minimal hepatitis B. A dose of 3 mg/kg once daily (up to a maximum of 100 mg daily) was used in children aged 2 to 11 years and a dose of 100 mg once daily in adolescents aged 12 years and above.
Croatian: Djeca od 2 do 11 godina dobivala su dozu od 3 mg/kg jedanput na dan (do maksimalno 100 mg na dan), dok su adolescenti u dobi od 12 godina i više dobivali dozu od 100 mg jedanput na dan.
English: Keep in touch with your doctor, and don't stop taking Zeffix without your doctor's advice.
Croatian: Budite u kontaktu sa svojim liječnikom i nemojte prestati uzimati Zeffix ako Vam to nije savjetovao liječnik.
English: • In patients with HBeAg positive chronic hepatitis B (CHB) without cirrhosis, treatment should be administered for at least 6-12 months after HBeAg seroconversion (HBeAg and HBV DNA loss with HBeAb detection) is confirmed, to limit the risk of virological relapse, or until HBsAg seroconversion or there is loss of efficacy (see section 4.4).
Croatian: • U HBeAg pozitivnih bolesnika s kroničnim hepatitisom B, a bez ciroze, liječenje treba provoditi najmanje 6 - 12 mjeseci nakon potvrđene serokonverzije HBeAg (gubitak HBeAg i HBV DNK uz pojavu HBeAb), kako bi se ograničio rizik od relapsa virusa, odnosno do serokonverzije HBsAg ili do gubitka djelotvornosti (vidjeti dio 4.4).
English: The most common adverse reactions reported were malaise and fatigue, respiratory tract infections, throat and tonsil discomfort, headache, abdominal discomfort and pain, nausea, vomiting and diarrhoea.
Croatian: Najčešće zabilježene nuspojave bile su malaksalost i umor, infekcije dišnih puteva, nelagoda u predjelu grla i tonzila, glavobolja, bol i nelagoda u trbuhu, mučnina, povraćanje i proljev.
English: Lamivudine is metabolised by both infected and uninfected cells to the triphosphate (TP) derivative which is the active form of the parent compound.
Croatian: Lamivudin se metabolizira i u zaraženim i u nezaraženim stanicama u trifosfatni derivat koji je aktivni oblik osnovnog spoja.
English: Therefore breastfeeding may be considered in breastfeeding mothers being treated with lamivudine for HBV taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Croatian: Stoga dojenje treba razmotriti u dojilja liječenih lamivudinom zbog HBV-a, pritom uzimajući u obzir prednosti dojenja za dijete i prednosti terapije za majku.
English: Lamivudine-TP acts as a substrate for the HBV viral polymerase.
Croatian: Lamivudin-trifosfat djeluje kao supstrat virusne polimeraze HBV-a.
English: The incidence of YMDD mutant HBV was similar to that observed in adults, ranging from 19 % at week 52 up to 45 % in patients treated continuously for 24 months.
Croatian: Incidencija YMDD tipa virusa bila je slična onoj u odraslih i kretala se od 19% u 52. tjednu do 45% u bolesnika koji su kontinuirano liječeni tijekom 24 mjeseca.
English: For HIV co-infected patients not requiring anti-retroviral therapy, there is a risk of HIV mutation when using lamivudine alone for treating chronic hepatitis B.
Croatian: U bolesnika zaraženih HIV-om kojima nije potrebna antiretrovirusna terapija postoji rizik od mutacije HIV-a pri monoterapiji lamivudinom za liječenje kroničnog hepatitisa B.