FrancophonIA/ELRC3.0 huggingface dataset:
English: Plasma concentrations of dextromethorphan and dextrorphan are proportional to dextromethorphan dose in the presence of a fixed dose of quinidine such as that contained in NUEDEXTA.
Slovenian: Plazemske koncentracije dekstrometorfana in dekstrorfana so sorazmerne z odmerkom dekstrometorfana v prisotnosti fiksnega odmerka kinidina, kot ga vsebuje zdravilo NUEDEXTA.
English: Caution should be used when this medicinal product is taken in combination with alcohol or other centrally acting medicinal products that might increase the risk of adverse reactions such as somnolence and dizziness.
Slovenian: Pri uporabi tega zdravila v kombinaciji z alkoholom ali drugimi zdravili z delovanjem na osrednje živčevje, ki lahko povečajo tveganje za neželene učinke, kot sta somnolenca in omotica, je treba biti previden.
English: If you have taken more capsules than you should, speak to your doctor immediately.
Slovenian: Če ste vzeli večji odmerek zdravila NUEDEXTA, kot bi smeli Če ste vzeli več kapsul, kot bi smeli, se nemudoma obrnite na svojega zdravnika.
English: During development of this medicinal product, dose combinations of dextromethorphan/quinidine containing up to 6-times higher dextromethorphan dose and 12-times higher quinidine dose were studied.
Slovenian: Med razvojem tega zdravila so proučili kombinacije odmerkov dekstrometorfana/kinidina, ki so vsebovale do 6-krat večji odmerek dekstrometorfana in 12-krat večji odmerek kinidina.
English: Approximately 7-8% of individuals of Caucasian descent, 3-6% of Black African descent, 2-3% of Arab descent and 1-2% of Asian descent generally lack the capacity to metabolize CYP2D6 substrates and are classified as Poor
Slovenian: Približno 7-8 % posameznikov kavkazijskega porekla, 3-6 % posameznikov afriškega črnega porekla, 2-3 % posameznikov arabskega porekla in 1-2 % posameznikov azijskega porekla v splošnem primanjkuje sposobnosti za presnavljanje substratov CYP2D6 in so označeni kot osebe s slabo presnovo.
English: Quinidine plasma concentrations are proportional to quinidine dose.
Slovenian: Plazemske koncentracije kinidina so sorazmerne z odmerkom kinidina.
English: Potent CYP3A4 inducers (e.g. rifampicin, phenytoin, phenobarbital, carbamazepine, St John's wort/Hypericum perforatum) may accelerate the metabolism of quinidine, resulting in lower plasma concentrations and hence decreased inhibition of CYP2D6.
Slovenian: Močni induktorji CYP3A4 (npr. rifampicin, fenitoin, fenobarbital, karbamazepin, šentjanževka/Hypericum perforatum) lahko pospešijo presnovo kinidina, kar povzroči manjše koncentracije v plazmi in posledično zmanjšano zaviranje encima CYP2D6.
English: • to continue the treatment with NUEDEXTA 15 mg/9 mg capsules, or
Slovenian: • za nadaljevanje zdravljenja z zdravilom NUEDEXTA 15 mg/9 mg kapsule ali
English: A population pharmacokinetic analysis based on data from 109 subjects (75 male; 34 female) showed no apparent gender differences in the pharmacokinetics of dextromethorphan/quinidine.
Slovenian: Farmakokinetična analiza populacije na podlagi podatkov 109 bolnikov (75 moških; 34 žensk) ni pokazala očitnih razlik med spoloma pri farmakokinetiki dekstrometorfana/kinidina.
English: Treatment with NUEDEXTA may therefore result in elevated plasma levels and accumulation of co-administered medicinal products that undergo extensive CYP2D6 metabolism.
Slovenian: Zdravljenje z zdravilom NUEDEXTA lahko zato povzroči povišane ravni v plazmi in kopičenje sočasnih zdravil, ki se obsežno presnavljajo z encimom CYP2D6.
English: The efficacy of dextromethorphan/quinidine for the treatment of PBA was demonstrated in three randomised, controlled, double-blind, multicentre clinical trials in PBA subjects with underlying amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS).
Slovenian: Učinkovitost dekstrometorfana/kinidina za zdravljenje PBP so proučevali v treh randomiziranih, nadzorovanih, dvojno slepih, multicentričnih kliničnih preskušanjih pri preskušancih s PBP in osnovno boleznijo, amiotrofično lateralno sklerozo (ALS) ali multiplo sklerozo (MS).
English: Tricyclic antidepressants (TCAs e.g. desipramine, nortriptyline, imipramine, amitriptyline) are metabolised by CYP2D6 and therefore are also subject to pharmacokinetic interaction with quinidine.
Slovenian: Triciklični antidepresivi (npr. dezipramin, nortriptilin, imipramin, amitriptilin) se presnavljajo z encimom CYP2D6, zato so prav tako izpostavljeni farmakokinetični interakciji s kinidinom.
English: Driving and using machines NUEDEXTA may cause dizziness.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zdravilo NUEDEXTA lahko povzroči omotico.
English: Dextromethorphan has been shown to be a mild/moderate inhibitor of the OCT1 transporter in vitro.
Slovenian: Pokazalo se je, da je dekstrometorfan blag/zmeren zaviralec prenašalca OCT1 in vitro.
English: • you experience symptoms such as bruising, bleeding under the skin, nosebleeds and/or bleeding gums, as this may be a sign of low levels of blood cells called platelets (thrombocytopenia).
Slovenian: • opazite simptome, kot so modrice, podkožne krvavitve, krvavitev iz nosu in/ali krvaveče dlesni, saj je to lahko znak nizkih ravni krvnih celic, imenovanih krvne ploščice ali trombociti (trombocitopenija);
English: This test dose is adequate to represent the steady state exposure in patients with CYP2D6 extensive metabolizer phenotype.
Slovenian: Ta testni odmerek zadovoljivo predstavlja izpostavljenost dinamičnemu ravnovesju pri bolnikih s fenotipom izčrpne presnove CYP2D6.
English: Patients receiving concomitant treatment with thioridazine, a medicinal product that both significantly prolongs QT interval and is primarily metabolized by CYP2D6.
Slovenian: Bolniki, ki se sočasno zdravijo s tioridazinom, zdravilom, ki pomembno podaljša interval QT in se primarno presnavlja z encimom CYP2D6.
English: ritonavir, saquinavir, amprenavir, fosamprenavir
Slovenian: indinavir, nelfinavir, ritonavir, sakvinavir, amprenavir, fosamprenavir;
English: The maximum daily dose from week 4 onwards is NUEDEXTA 23 mg/9 mg, twice daily.
Slovenian: Največji odmerek zdravila NUEDEXTA od 4. tedna naprej je 23 mg/9 mg dvakrat na dan.
English: • you experience symptoms, such as yellowing of the skin or eyes, dark urine, nausea or vomiting, loss of appetite, abdominal pain, and fever, as this may be a sign of drug-induced hepatitis (liver inflammation).
Slovenian: • opazite simptome, kot so porumenelost kože ali oči, temen urin, navzea ali bruhanje, izguba apetita, bolečine v trebuhu in vročina, saj je to lahko znak z zdravili povzročenega hepatitisa (vnetja jeter);
English: When initiating treatment with NUEDEXTA in patients at risk of QT prolongation, electrocardiographic (ECG) evaluation of the QT interval should be conducted at baseline and at 2 hours after the first dose administered in the fasted state (approximates to quinidine Tmax).
Slovenian: Če se zdravljenje z zdravilom NUEDEXTA uvaja pri bolnikih s tveganjem podaljšanja intervala QT, je treba ob izhodišču in 2 uri po prvem odmerku na tešče (kar je blizu Tmax kinidina) opraviti elektrokardiografsko (EKG) oceno intervala QT.
English: The tricyclic antidepressant desipramine is metabolized primarily by CYP2D6.
Slovenian: Triciklični antidepresiv dezipramin se primarno presnavlja z encimom CYP2D6.
English: Patients with renal and hepatic impairment
Slovenian: Bolniki z ledvično in jetrno okvaro
English: Concomitant administration of quinidine with digoxin, a P-glycoprotein substrate, results in serum digoxin levels that may be as much as doubled.
Slovenian: Sočasna uporaba kinidina in digoksina, substrata P-glikoproteina, povzroči tudi do dvakrat višje ravni digoksina v serumu.
English: • medicines to treat epilepsy or fits, such as phenytoin, carbamazepine and phenobarbital
Slovenian: • zdravila za zdravljenje epilepsije in napadov, npr. fenitoin, karbamazepin in fenobarbital.
English: The quinidine component is intended to inhibit CYP2D6 so that higher exposure to dextromethorphan can be achieved compared to when dextromethorphan is given alone.
Slovenian: Kinidinska komponenta je namenjena zaviranju CYP2D6, da je mogoče doseči višjo izpostavljenost dekstrometorfanu v primerjavi z dajanjem dekstrometorfana samostojno.
English: Neither dextromethorphan nor quinidine induced CYP1A2, CYP2B6 or CYP3A4 in human hepatocytes at concentrations up to 4.8 µM.
Slovenian: Dekstrometorfan in kinidin nista inducirala CYP1A2, CYP2B6 ali CYP3A4 v človeških hepatocitih pri koncentracijah do 4,8 µM.
English: No more than 2 capsules should be taken in any 24-hour period, with 12 hours between each dose.
Slovenian: Bolnik v 24-urnem obdobju ne sme vzeti več kot 2 kapsuli, pri čemer mora biti presledek med vsakim odmerkom 12 ur.
English: The risk of thrombocytopenia in association with the lower dose of quinidine in NUEDEXTA is unknown.
Slovenian: Tveganje za trombocitopenijo, povezano z manjšim odmerkom kinidina v zdravilu NUEDEXTA, ni znano.
English: Thioridazine, a CYP2D6 substrates that also prolong the QT interval is contraindicated (see section 4.3).
Slovenian: Tioridazin, substrat encima CYP2D6, ki prav tako podaljša interval QT, je kontraindiciran (glejte poglavje 4.3).
English: If you forget to take NUEDEXTA
Slovenian: Če ste pozabili vzeti zdravilo NUEDEXTA
English: • dizziness, headache, drowsiness
Slovenian: • omotica, glavobol, dremavost
English: • heart attack (myocardial infarction), heart palpitations
Slovenian: • srčna kap (miokardni infarkt), palpitacije srca
English: Drug interactions with desipramine and paroxetine have been studied in controlled clinical trials with a higher dose combination of dextromethorphan/quinidine (dextromethorphan 23 mg/ quinidine 26 mg) than in this medicinal product; study results are described below.
Slovenian: Medsebojno delovanje z dezipraminom in paroksetinom so proučevali v nadzorovanih kliničnih preskušanjih z večjim odmerkom kombinacije dekstrometorfana/kinidina (23 mg dekstrometorfana/26 mg kinidina) kot v tem zdravilu; rezultati študij so opisani spodaj.
English: However, as there was a trend toward increased incidence of adverse reactions in patients with moderate hepatic impairment, additional monitoring of adverse reactions is advised in these patients.
Slovenian: Če pa se pri bolnikih z zmerno jetrno okvaro pojavi povečana pojavnost neželenih učinkov, se pri teh bolnikih priporoča dodatno spremljanje neželenih učinkov.
English: In all studies, the efficacy endpoints were “Count of episodes of laughing and crying” (PBA episodes) and subject scores on the Center for Neurologic Studies - Lability Scale (CNS-LS), a validated 7-item, self-administered questionnaire that provides a quantitative measure of the frequency and severity of PBA. CNS-LS scores range from a minimum of 7 (no symptoms) to a maximum of 35.
Slovenian: V vseh študijah je bil opazovani dogodek učinkovitosti „število epizod smeha in joka“ (epizod PBP) in rezultat preskušanca na lestvici labilnosti Centra za nevrološke študije - Lability Scale (CNS-LS), validiranem 7-stopenjskem vprašalniku za samostojno reševanje, ki omogoča kvantitativno meritev pogostnosti in resnosti PBP.
English: Patients with a prolonged QT interval, congenital long QT syndrome or a history suggestive of torsades de pointes ventricular tachycardia (see section 4.4).
Slovenian: Bolniki s podaljšanim intervalom QT, kongenitalnim sindromom dolgega intervala QT ali anamnezo, ki kaže na ventrikularno tahikardijo tipa torsades de pointes (glejte poglavje 4.4).
English: Rare (may affect up to 1 in 1,000 people)
Slovenian: Redki (pojavijo se lahko prinajveč 1 od 1.000 bolnikov)
English: Only for NUEDEXTA 15 mg/9 mg: Blister packs consist of a PVC based clear film with aluminium foil seal and contains 13 hard capsules.
Slovenian: Le za zdravilo NUEDEXTA 15 mg/9 mg: Pretisni omot je izdelan iz z prozorne folije na osnovi PVCja in iz aluminijaste folije ter vsebuje 13 trdih kapsul.
English: Uncommon side effects (may affect up to 1 in 100 people)
Slovenian: Občasni neželeni učinki (pojavijo se lahko prinajveč 1 od 100 bolnikov)
English: Blister of a PVC based clear film with aluminium foil seal.
Slovenian: Pretisni omot iz prozorne folije na osnovi PVC-ja in z aluminijasto folijo.
English: flecainide and beta-blockers (such as metoprolol)
Slovenian: digoksin, flekainid in beta-adrenergične antagoniste (npr. metoprolol);
English: There was no significant difference in the plasma concentrations of dextromethorphan and dextrorphan before and after the administration of memantine, and there was no effect on the plasma concentrations of memantine before and after the administration of dextromethorphan/quinidine.
Slovenian: Razlika v koncentracijah dekstrometorfana ter dekstrorfana v plazmi pred uporabo memantina in po njej ni bila statistično pomembna, učinkov na koncentracije memantina v plazmi pred uporabo kombinacije dekstrometorfana/kinidina in po njej pa ni bilo.
English: • redness of the skin (erythema), excessive sweating (hyperhidrosis), loss of sensation or numbness of the face, night sweats
Slovenian: • pordelost kože (eritem), prekomerno znojenje (hiperhidroza), izguba občutka ali odrevenelost obraza, nočno potenje
English: • if you are already taking medicines containing quinidine, quinine, or mefloquine.
Slovenian: • če že jemljete zdravila, ki vsebujejo kinidin, kinin ali meflokin.
English: If you forget to take 1 or more capsules, you must not take a double dose to make up for the missed doses.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti 1 ali več kapsul.
English: • Bruxism, Confusional state, Depressed mood, Depression, Disorientation, Early morning awakening, Flat affect, Hallucination, Impulsive behaviour, Indifference, Insomnia, Restlessness, Sleep disorder
Slovenian: • bruksizem, konfuznost, depresivno razpoloženje, depresija, dezorientiranost, zbujanje zgodaj zjutraj, apatičnost, halucinacije, impulzivno vedenje, indiferentnost, nespečnost, nemir, motnje spanja
English: • to give you a higher dose and to prescribe NUEDEXTA 23 mg/9 mg capsules to you.
Slovenian: • za dvig odmerka in vam bo predpisal zdravilo NUEDEXTA 23 mg/9 mg kapsule.
English: Pack size: 13 capsules
Slovenian: Velikost pakiranja: 13 kapsul
English: • Myocardial infarction, Palpitations, Ventricular extrasystoles
Slovenian: • miokardni infarkt, palpitacije, prekatne ekstrasistole
English: If you stop taking NUEDEXTA
Slovenian: Če ste prenehali jemati zdravilo NUEDEXTA
English: The potential for dextromethorphan and quinidine to inhibit or induce cytochrome P450 in vitro were evaluated in human microsomes.
Slovenian: Študije medsebojnega delovanja s CYP P450 in vitro Potencial dekstrometorfana in kinidina za zaviranje ali indukcijo citokroma P450 in vitro je bil ocenjen na človeških mikrosomih.
English: Approximately 1-10% of individuals of Caucasian descent, 5-30% of Black African descent, 12-40% of Arab descent and 1% of Asian descent exhibit increased metabolic activity for CYP2D6 substrates and are classified as Ultra-rapid Metabolizer (UMs).
Slovenian: Približno 1-10 % posameznikov kavkazijskega porekla, 5-30 % posameznikov afriškega črnega porekla, 12-40 % posameznikov arabskega porekla in 1 % posameznikov azijskega porekla izkazuje povišano presnovno dejavnost za substrate CYP2D6, zato so označeni kot osebe z izjemno hitro presnovo.
English: They include, but are not limited to, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil.
Slovenian: Ti med drugim vključujejo atazanavir, klaritromicin, indinavir, itrakonazol, ketokonazol, nefazodon, nelfinavir, ritonavir, sakvinavir, telitromicin, amprenavir, aprepitant, diltiazem, eritromicin, flukonazol, fosamprenavir, sok grenivke in verapamil.
English: • distorted sense of taste (dysgeusia), sleepiness (hypersomnia), muscle spasticity, fainting
Slovenian: • moten čut za okus (disgevzija), zaspanost (hipersomnija), mišična spastičnost, omedlevica
English: In extensive metabolizers, mean Cmax and AUC0-12 values of dextromethorphan and dextrorphan increased as doses of dextromethorphan increased from 15 mg to 23 mg and mean Cmax and AUC0-12 values of quinidine were similar.
Slovenian: Pri osebah z obsežno presnovo so se vrednosti Cmax in AUC0-12 dekstrometorfana in dekstrorfana povišale s povišanjem odmerkov dekstrometorfana s 15 mg na 23 mg, povprečne vrednosti Cmax in AUC0-12 kinidina pa so bile podobne.
English: Dextromethorphan is rapidly metabolized by CYP2D6 to its primary metabolite, dextrorphan, which is rapidly glucuronidated and renally eliminated.
Slovenian: Dekstrometorfan se hitro presnavlja s CYP2D6 v svoj osnovni metabolit, dekstrorfan, ki se hitro spremeni v glukuronid in izloči prek ledvic.
English: In this placebo-controlled 12-week study, 326 PBA subjects with underlying ALS or MS were randomized to receive NUEDEXTA 15 mg / 9 mg, (n=107), NUEDEXTA 23 mg / 9 mg (n=110), or placebo (n=109) for 12 weeks.
Slovenian: V tej 12-tedenski študiji, nadzorovani s placebom, so randomizirali 326 preskušancev s PBP in z amiotrofično lateralno sklerozo (ALS) ali multiplo sklerozo (MS) kot osnovno boleznijo, tako da so 12 tednov prejemali zdravilo NUEDEXTA 15 mg/9 mg, (n=107), NUEDEXTA 23 mg/9 mg (n=110) ali placebo (n=109).
English: ECG should be re-evaluated if risk factors for QTc prolongation change significantly during treatment with NUEDEXTA.
Slovenian: Če se dejavniki tveganja za podaljšanje intervala QTc med zdravljenjem z zdravilom NUEDEXTA znatno spremenijo, je treba ponovno oceniti EKG.
English: Other effects include loss of coordinated movement (ataxia), involuntary eye movements (nystagmus), over contraction of the muscles (dystonia), blurred vision, and changes in muscle reflexes.
Slovenian: Drugi učinki vključujejo izgubo koordiniranega gibanja (ataksija), nehotene očesne premike (nistagmus), prekomerno krčenje mišic (distonija), zamegljen vid in spremembe mišičnih refleksov.
English: In embryo-fetal and developmental toxicity studies (rats and rabbits) with dextromethorphan hydrobromide/quinidine sulfate, abnormalities were observed at mid and high dose with reduced ossification from the lowest dose in rats which is approximately 1 and 50 times the human dose of 30/18 mg/day on a mg/m basis, respectively.
Slovenian: V študijah embriofetalne in razvojne toksičnosti (pri podganah in kuncih) z dekstrometorfanijevim bromidom/kinidinijevim sulfatom so opazili anomalije pri srednjem in visokem odmerku z zmanjšano osifikacijo od najnižjega odmerka pri podganah, kar je približno 1-kratnik in 50-kratnik odmerka za človeka 30/18 mg/dan na podlagi mg/m2.
English: NUEDEXTA has the potential to cause QTc prolongation and hence torsades de pointes-type ventricular tachycardia.
Slovenian: Zdravilo NUEDEXTA lahko podaljša interval QTc in posledično povzroči ventrikularno tahikardijo tipa torsades de pointes.
English: After administration of NUEDEXTA 23 mg/9 mg to 14 extensive metabolizers, the elimination halflife of dextromethorphan was 18.8 hours and the elimination half-life of quinidine was 9.6 hours.
Slovenian: Po dajanju zdravila NUEDEXTA 23 mg/9 mg 14 osebam z obsežno presnovo je bil razpolovni čas izločanja dekstrometorfana 18,8 ure, razpolovni čas izločanja kinidina pa je bil 9,6 ure.
English: If the clinical response with NUEDEXTA 15 mg/9 mg is inadequate, NUEDEXTA 23 mg/9 mg should be prescribed, taken two times per day, one in the morning and one in the evening, 12 hours apart.
Slovenian: Če je klinični odziv z zdravilom NUEDEXTA 15 mg/9 mg nezadosten, je treba predpisati zdravilo NUEDEXTA 23 mg/9 mg, ki ga mora bolnik jemati dvakrat na dan, po eno kapsulo zjutraj in eno zvečer z 12-urnim presledkom.
English: The most common adverse reactions were mild to moderate nausea, dizziness, and headache.
Slovenian: Najpogostejši neželeni učinki so bili blaga do zmerna navzea, omotica in glavobol.
English: Dextromethorphan hydrobromide is the pharmacologically active ingredient that acts on the central nervous system (CNS).
Slovenian: Dekstrometorfanijev bromid je farmakološko aktivna zdravilna učinkovina, ki deluje na osrednje živčevje.
English: Quinidine increases plasma levels of dextromethorphan by competitively inhibiting cytochrome P450 2D6 (CYP2D6), which catalyses a major biotransformation pathway for dextromethorphan.
Slovenian: Kinidin poviša ravni dekstrometorfana v plazmi, tako da kompetitivno zavira citokrom P450 2D6 (CPY2D6), ki katalizira glavno pot biotransformacije dekstrometorfana.
English: • chest discomfort, chest pain, chills, feeling hot, gait disturbance (difficulty walking), flu-like illness, fever, decreased oxygen levels in the blood
Slovenian: • neugodje v prsnem košu, bolečina v prsnem košu, mrzlica, občutek vročine, motnje hoje (težave pri hoji), gripi podobna bolezen, vročina, znižane ravni kisika v krvi
English: Pup survival and pup weight were slightly decreased from the lowest dose corresponding approximately to 1and 50 times the human dose of 30/18 mg/kg on a mg/m2 basis, for dextromethorphan hydrobromide and quinidine sulfate, respectively.
Slovenian: Preživetje mladičev in telesna masa mladičev sta bila nekoliko zmanjšana pri najnižjem odmerku, ki ustreza približno 1-kratniku in 50-kratniku odmerka za ljudi v višini 30/18 mg/kg na podlagi mg/m za dekstrometorfan bromid oziroma kinidin sulfat.
English: Fertility In pre-clinical studies no effect on fertility was observed in male and female rats (see section 5.3).
Slovenian: V predkliničnih študijah na podganjih samcih in samicah niso opazili nobenega učinka na plodnost (glejte poglavje 5.3).
English: • Co-administration of a strong CYP3A4 inhibitor
Slovenian: • sočasnim dajanjem močnega zaviralca CYP3A4;
English: Talk to your doctor before and after taking NUEDEXTA if:
Slovenian: Pred začetkom jemanja zdravila NUEDEXTA in po njem se posvetujte z zdravnikom, če:
English: Based on literature citations, drug-drug interactions as a result of quinidine inhibition of OATP1B1, OCT1, OCT2, OAT3, BSEP, MATE1, and MATE2-K are not expected.
Slovenian: Na podlagi podatkov iz literature medsebojnega delovanja zdravil kot posledice zaviranja OATP1B1, OCT1, OCT2, OAT3, BSEP, MATE1 in MATE2-K, ki bi ga povzročal kinidin, ni pričakovati.
English: In the presence of quinidine, CYP3A4-dependent oxidative metabolism is believed to play a greater role in dextromethorphan elimination.
Slovenian: Predvideva se, da ima v prisotnosti kinidina oksidativna presnova, odvisna od CYP3A4, večjo vlogo pri izločanju dekstrometorfana.
English: What NUEDEXTA looks like and contents of the pack
Slovenian: Izgled zdravila NUEDEXTA in vsebina pakiranja
English: Dextromethorphan can also be associated with hypersensitivity reactions, including uticaria, angioedema, and shortness of breath.
Slovenian: Dekstrometorfan je lahko povezan tudi s preobčutljivostnimi reakcijami, vključno z urtikarijo, angioedemom in zasoplostjo.
English: • medicines containing quinidine, quinine, or mefloquine.
Slovenian: • zdravila, ki vsebujejo kinidin, kinin ali meflokin.
English: Symptoms of quinidine overdose include irregular heartbeat and low blood pressure, and may also include vomiting, diarrhoea, ringing in the ears, high-frequency hearing loss, vertigo, blurred vision, double vision, increased sensitivity of the eyes to light, headache, confusion, and delirium (characterised by loss of attention, poor memory, disorientation, impaired speech).
Slovenian: Simptomi prevelikega odmerjanja kinidina so nereden srčni ritem in nizek krvni tlak, vključujejo pa lahko tudi bruhanje, drisko, zvenenje v ušesih, izgubo sluha za visoke frekvence, vrtoglavico, zamegljen vid, dvojni vid, povečano občutljivost oči za svetlobo, glavobol, zmedenost in delirij (za katerega je značilno pomanjkanje pozornosti, slab spomin, dezorientiranost in otežen govor).
English: Fever may be a presenting symptom, and thrombocytopenia or other signs of hypersensitivity may also occur.
Slovenian: Na to lahko kaže povišana telesna temperatura, pojavijo pa se lahko tudi trombocitopenija ali drugi znaki preobčutljivosti.