FrancophonIA/ELRC3.0 huggingface dataset:
English: It is recommended that infections suspected or proven to be due to less susceptible bacterial species (such as Pseudomonas aeruginosa) and very severe infections (e.g. in neutropenic patients with a fever) should be treated with 1000 mg/1000 mg administered every 6 hours.
Slovenian: Priporočeno je, da se pri okužbah, za katere obstaja sum oz. za katere je dokazano, da jih povzročajo manj občutljive vrste bakterij (kot je Pseudomonas aeruginosa), in zelo hudih okužbah (npr. pri nevtropeničnih bolnikih z zvišano telesno temperaturo) bolnike zdravi z odmerki 1.000 mg/1.000 mg vsakih 6 ur.
English: IV.
Slovenian: i.v.
English: The average clearance (CL) and volume of distribution (Vdss) for imipenem were approximately 45% higher in paediatric patients (3 months to 14 years) as compared to adults.
Slovenian: Pri pediatričnih bolnikih (starih od 3 mesece do 14 let) sta bila povprečni očistek (CL) in volumen porazdelitve (Vdss) imipenema pribilžno 45% večja kot pri odraslih.
English: Ureoplasma urealyticum * All methicillin-resistant staphylococci are resistant to imipenem/cilastatin.
Slovenian: Ureoplasma urealyticum *Vsi proti meticilinu odporni stafilokoki so odporni tudi proti imipenemu/cilastatinu.
English: When treating patients with creatinine clearances of 5 ml/min/1.73 m2 who are undergoing dialysis use the dose recommendation for patients with creatinine clearances of 6 to 20 ml/min/1.73 m2 (see table 1).
Slovenian: Za zdravljenje bolnikov z očistkom kreatinina 5 ml/min/1,73 m2, ki so na dializi, je treba uporabiti priporočeni odmerek za bolnike z očistkom kreatinina 6 do 20 ml/min/1,73 m2 (glejte preglednico 1).
English: Very rare haemolytic anaemia, bone marrow depression
Slovenian: Zelo redki hemolitična anemija, depresija kostnega mozga
English: • Streptococcus A, B, C, G: The beta-lactam susceptibility of beta-haemolytic streptococcus groups A,
Slovenian: Streptococcus A, B, C, G: sklepanje o občutljivosti beta-hemolitičnih streptokokov skupin A, B, C in G za betalaktame temelji na občutljivosti za penicilin.
English: Following a single 250 mg/250 mg intravenous dose of TIENAM given 24 hours after haemodialysis, AUCs for imipenem and cilastatin were 3.7-fold and 16.4-fold higher, respectively, as compared to subjects with normal renal function.
Slovenian: Po enkratnem intravenskem odmerku 250 mg/250 mg zdravila TIENAM, uporabljenem 24 ur po hemodializi, je bila AUC imipenema 3,7-krat večja in AUC cilastatina 16,4-krat večja kot pri osebah z normalnim delovanjem ledvic.
English: Species resistant to other carbapenems do generally express co-resistance to imipenem.
Slovenian: Vrste, odporne proti drugim karbapenemom, so praviloma odporne tudi proti imipenemu.
English: If you are concerned that you may have been given too much TIENAM, contact your doctor or another healthcare professional immediately.
Slovenian: Če vas skrbi, da ste dobili preveč zdravila TIENAM, to nemudoma povejte zdravniku ali drugemu zdravstvenemu delavcu.
English: TIENAM should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Slovenian: Zdravilo TIENAM naj bi med nosečnostjo uporabili le, če možna korist upravičujejo možno tveganje za plod.
English: Rare encephalopathy, paraesthesia, focal tremor, taste perversion
Slovenian: Redki encefalopatija, parestezije, fokalni tremor, motnje okušanja
English: The usual dose of TIENAM for adults and adolescents is 500 mg/500 mg every 6 hours or 1,000 mg/1,000 mg every 6 or 8 hours.
Slovenian: Običajen odmerek zdravila TIENAM za odrasle in mladostnike je 500 mg/500 mg na vsakih 6 ur ali 1.000 mg/1.000 mg na vsakih 6 ali 8 ur.
English: Symptoms of overdose may include seizures, confusion, tremors, nausea, vomiting, low blood pressure and slow heart rate.
Slovenian: Če ste uporabili večji odmerek zdravila TIENAM, kot bi smeli Simptomi prevelikega odmerjanja lahko vključujejo napade krčev, zmedenost, tresenje, siljenje na bruhanje, bruhanje, nizek krvni tlak in počasen srčni utrip.
English: • Severe hypersensitivity (e.g. anaphylactic reaction, severe skin reaction) to any other type of beta lactam antibacterial agent (e.g. penicillins or cephalosporins).
Slovenian: Huda preobčutljivost (npr. anafilaktična reakcija, huda kožna reakcija) za katerokoli drugo betalaktamsko protibakterijsko zdravilo (npr. za peniciline ali cefalosporine).
English: For patients on haemodialysis, TIENAM is recommended only when the benefit outweighs the potential risk of seizures (see section 4.2).
Slovenian: Za bolnike na hemodializi je zdravilo TIENAM priporočljivo le, če korist odtehta možno tveganje za napade krčev (glejte poglavje 4.2).
English: Very rare haemorrhagic colitis, abdominal pain, heartburn, glossitis, tongue papilla hypertrophy, increased salivation
Slovenian: Zelo redki hemoragični kolitis, bolečine v trebuhu, zgaga, glositis, hipertrofija papil na jeziku, močnejše slinjenje
English: Uncommon seizures, myoclonic activity, dizziness, somnolence
Slovenian: Občasni napadi krčev, mioklonična aktivnost, omotica, zaspanost
English: Children TIENAM is not recommended in children less than one year of age or children with kidney problems.
Slovenian: Uporabe zdravila TIENAM ne priporočamo pri otrocih, mlajših od enega leta starosti, in pri otrocih z ledvičnimi težavami.
English: If you are concerned that you may have missed a dose, contact your doctor or another healthcare professional immediately.
Slovenian: Če vas skrbi, da niste dobili odmerka zdravila, to nemudoma povejte zdravniku ali drugemu zdravstvenemu delavcu.
English: Uncommon fever, local pain and induration at the injection site, erythema at the injection site
Slovenian: Občasni zvišana telesna temperatura, lokalne bolečine in zatrdlina na mestu injiciranja, eritem na mestu injiciranja
English: • Hypersensitivity to the active substances or to any of the excipients
Slovenian: Preobčutljivost za zdravilni učinkovini ali katero od pomožnih snovi.
English: The following information is intended for medical or healthcare professionals only: Each vial is for single use only.
Slovenian: Naslednje informacije so namenjene samo zdravstvenemu osebju:
English: The following adverse reactions have been reported in clinical studies or during post-marketing experience.
Slovenian: V kliničnih študijah in v obdobju trženja zdravila so poročali o naslednjih neželenih učinkih.
English: Following a single 250 mg/250 mg intravenous dose of TIENAM, the area under the curve (AUCs) for imipenem increased 1.1-fold, 1.9-fold, and 2.7-fold in subjects with mild (Creatinine Clearance (CrCL) 50-80 ml/min/1.73 m2), moderate (CrCL 30-<50 ml/min/1.73 m2), and severe (CrCL <30 ml/min/1.73 m2) renal impairment, respectively, compared to subjects with normal renal function (CrCL >80 ml/min/1.73 m2), and AUCs for cilastatin increased 1.6-fold, 2.0-fold, and 6.2-fold in subjects with mild, moderate, and severe renal impairment, respectively, compared to subjects with normal renal function.
Slovenian: Po enkratnem intravenskem odmerku 250 mg/250 mg zdravila TIENAM je bila površina pod krivuljo (AUC) imipenema pri bolnikih blago okvaro ledvic (očistek kreatinina (CrCL) 50-80 ml/min/1,73 m2) 1,1-krat večja, z zmerno okvaro ledvic (CrCL 30-<50 ml/min/1,73 m2) 1,9-krat večja in s hudo okvaro ledvic (CrCL <30 ml/min/1,73 m2) 2,7-krat večja kot pri osebah z normalnim delovanjem ledvic (CrCL >80 ml/min/1,73 m2).
English: Very rare chest discomfort, asthenia/weakness
Slovenian: Zelo redki nelagodje v prsih, astenija/šibkost
English: Imipenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in Gram-positive and Gram-negative bacteria through binding to penicillin-binding proteins (PBPs).
Slovenian: Imipenem deluje baktericidno z zavrtjem sinteze bakterijske celične stene grampozitivnih in gramnegativnih bakterij z vezavo na penicilin vežoče beljakovine.
English: Do not store above 25 C.
Slovenian: Shranjujte pri temperaturi do 25C.
English: Urinary recovery, renal clearance and plasma clearance of imipenem and cilastatin decrease with decreasing renal function following intravenous administration of TIENAM.
Slovenian: Pojavljanje imipenema in cilastatina v urinu, njun ledvični očistek in plazemski očistek se po intravenski uporabi zdravila TIENAM z zmanjševanjem delovanja ledvic zmanjšujejo.
English: It is important that you tell your doctor if you are breast-feeding or if you intend to breast-feed before receiving TIENAM.
Slovenian: Pomembno je, da zdravniku poveste, če dojite ali če nameravate dojiti, preden dobite zdravilo TIENAM.
English: Paediatric population with renal impairment
Slovenian: Pediatrični bolniki z okvaro ledvic
English: TIENAM is given intravenously (into a vein) over 20-30 minutes for a dose of ≤500 mg/500 mg or 40-60 minutes for a does of >500 mg/500 mg.
Slovenian: Zdravilo TIENAM se daje intravensko (v veno), in sicer v 20 do 30 minutah pri odmerkih ≤ 500 mg/500 mg in v 40-60 minutah pri odmerkih > 500 mg/500 mg.
English: Concomitant administration of TIENAM and probenecid resulted in minimal increases in the plasma levels and plasma half-life of imipenem.
Slovenian: Pri sočasni uporabi zdravila TIENAM in probenecida sta se koncentracija in razpolovni čas imipenema v plazmi minimalno povečala.
English: Intravenous use after reconstitution.
Slovenian: intravenska uporaba po pripravi samo za enkratno uporabo
English: Each vial contains sodium bicarbonate equivalent to approximately 1.6 mEq of sodium (approximately 37.6 mg).
Slovenian: Ena viala vsebuje približno 1,6 mEq natrija v obliki natrijevega hidrogenkarbonata (približno 37,6 mg).
English: When administered alone, imipenem is metabolized in the kidneys by dehydropeptidase-I.
Slovenian: Če je imipenem uporabljen sam, se v ledvicah presnovi z dihidropeptidazo-I.
English: Haematology A positive direct or indirect Coombs test may develop during treatment with imipenem/cilastatin.
Slovenian: Med zdravljenjem z imipenemom/cilastatinom se lahko pojavi pozitiven rezultat neposrednega ali posrednega Coombsovega testa.
English: Generalized seizures have been reported in patients who received ganciclovir and TIENAM.
Slovenian: Pri bolnikih, ki so prejemali ganciklovir in zdravilo TIENAM, so poročali o generaliziranih napadih krčev.
English: TIENAM may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection.
Slovenian: Zdravilo TIENAM se lahko uporablja za zdravljenje nevtropeničnih bolnikov z zvišano telesno temperaturo, če obstaja sum, da je vzrok zvišane temperature bakterijska okužba.
English: Pharmacotherapeutic group: Antibacterials for systemic use, carbapenems, ATC code: J01D H51
Slovenian: Oznaka ATC: J01D H51
English: Others: Chlamydia spp.
Slovenian: Drugi: Chlamydia spp.
English: Very rare dyspnoea, hyperventilation, pharyngeal pain
Slovenian: Zelo redki dispneja, hiperventilacija, bolečine v žrelu
English: Portugal: Tienam IV
Slovenian: Portugalska: Tienam IV
English: It kills a wide range of bacteria (germs) that cause infections in various parts of the body in adults and children one year of age and above.
Slovenian: Pri odraslih in otrocih, starih eno leto ali več, uniči širok spekter bakterij (klic), ki povzročajo okužbe v različnih delih telesa.
English: Elderly population No dose adjustment is required for the elderly patients with normal renal function (see section 5.2).
Slovenian: Starejša populacija Starejšim bolnikom z normalnim delovanjem ledvic odmerka ni treba prilagoditi (glejte poglavje 5.2).
English: Both imipenem and cilastatin are cleared from the circulation during haemodialysis.
Slovenian: Imipenem in cilastatin se med hemodializo odstranita iz obtoka.
English: Oral anti-coagulants
Slovenian: Peroralni antikoagulanti
English: Increases in serum transaminases and in alkaline phosphatase are also commonly reported.
Slovenian: Pogosto so poročali tudi o zvišanju serumskih transaminaz in alkalne fosfataze.
English: Spain: TIENAM IV
Slovenian: Španija: TIENAM IV
English: There is no target-based cross-resistance between imipenem and agents of the quinolone, aminoglycoside, macrolide and tetracycline classes.
Slovenian: Med imipenemom in učinkovinami iz kinolonske, aminoglikozidne, makrolidne in tetraciklinske skupine ni navzkrižne odpornosti na podlagi cilja.
English: Uncommon pancytopenia, neutropenia, leucopenia, thrombocytopenia, thrombocytosis
Slovenian: Občasni pancitopenija, nevtropenija, levkopenija, trombocitopenija, trombocitoza
English: Paediatric population ≥1 year of age
Slovenian: Pediatrični bolniki, stari ≥1 leto
English: Iceland: Tienam
Slovenian: Islandija: Tienam
English: Romania: TIENAM IV
Slovenian: Romunija: TIENAM IV
English: ** When the 500 mg/500 mg dose is used in patients with creatinine clearances of 6 to 20 ml/min/l.73 m2,
Slovenian: **Če je odmerek 500 mg/500 mg uporabljen pri bolnikih z očistkom kreatinina od 6 do 20 ml/min/1,73 m2, lahko obstaja večje tveganje za napade krčev.
English: What TIENAM looks like and contents of the pack TIENAM is a white to light yellow powder for solution for infusion in a glass vial.
Slovenian: Zdravilo TIENAM je bel do svetlorumen prašek za raztopino za infundiranje v stekleni viali.
English: - The other ingredient is sodium bicarbonate.
Slovenian: Pomožna snov je natrijev hidrogenkarbonat.
English: TIENAM 500 mg/500 mg contains 37.6 mg of sodium (1.6 mEq) which should be taken into consideration by patients on a controlled sodium diet.
Slovenian: Zdravilo TIENAM 500 mg/500 mg vsebuje 37,6 mg (1,6 mEq) natrija.
English: A reduction in dose is necessary when:  creatinine clearance is ≤ 70 ml/min/l.73 m2 (see Table 1) or
Slovenian: Zmanjšanje odmerka je potrebno pri: očistku kreatinina  70 ml/min/1,73 m2 (glejte preglednico 1) ali telesni masi < 70 kg.
English: • Allergic reactions including rash, swelling of the face, lips, tongue and/or throat (with difficulty in breathing or swallowing), and/or low blood pressure.
Slovenian: Redki alergijske reakcije, vključno z izpuščajem, oteklostjo obraza, ustnic, jezika in/ali žrela (s težavami pri dihanju ali požiranju) in/ali nizek krvni tlak; če se ti neželeni učinki pojavijo med prejemanjem zdravila TIENAM ali potem, je treba dajanje zdravila prekiniti in nemudoma obvestiti zdravnika.
English: Concomitant administration of TIENAM and probenecid doubled the plasma level and half-life of cilastatin, but had no effect on urine recovery of cilastatin.
Slovenian: Pri sočasni uporabi zdravila TIENAM in probenecida sta se koncentracija in razpolovni čas cilastatina v plazmi podvojila, izločanje cilastatina v urin pa se ni spremenilo.
English: United Kingdom: Primaxin IV
Slovenian: Velika Britanija: Primaxin IV
English: Ireland: Primaxin IV
Slovenian: Irska: Primaxin IV
English: Uncommon urticaria, pruritus
Slovenian: Občasni urtikarija, srbenje
English: Patients on haemodialysis
Slovenian: Bolniki na hemodializi
English: Very rare flushing
Slovenian: Zelo redki zardevanje
English: The urinary recovery of active (non-metabolized) imipenem decreased to approximately 60% of the dose when TIENAM was administered with probenecid.
Slovenian: Če je bilo zdravilo TIENAM uporabljeno s probenecidom, se je pojavljanje aktivnega (nepresnovljenega) imipenema v urinu zmanjšalo na približno 60% odmerka.
English: Decreases in valproic acid levels that may fall below the therapeutic range have been reported when valproic acid was co-administered with carbapenem agents.
Slovenian: Med sočasno uporabo valprojske kisline in karbapenemskih zdravil so poročali o zmanjšanju koncentracije valprojske kisline, ki lahko pade pod terapevtsko območje.
English: France: TIENAM
Slovenian: Francija: TIENAM
English: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams.
Slovenian: Pri bolnikih, zdravljenih z betalaktamskimi antibiotiki, so poročali o resnih in občasno smrtnih primerih preobčutljivostnih (anafilaktičnih) reakcij.
English: Anticonvulsant therapy should be continued in patients with a known seizure disorder.
Slovenian: Pri bolnikih z znano boleznijo, ki jo spremljajo napadi krčev, je treba nadaljevati zdravljenje z antiepileptiki.
English: Rare hepatic failure, hepatitis
Slovenian: Redki odpoved jeter, hepatitis
English: In normal volunteers, intravenous infusion of TIENAM over 20 minutes resulted in peak plasma levels of imipenem ranging from 12 to 20 μg/ml for the 250 mg/250 mg dose, from 21 to 58 μg/ml for the 500 mg/500 mg dose, and from 41 to 83 μg/ml for the 1000 mg/1000 mg dose.
Slovenian: Pri zdravih prostovoljcih so bile po 20-minutnem intravenskem infundiranju zdravila TIENAM največje koncentracijo imipenema v plazmi: od 12 do 20 µg/ml pri odmerku 250 mg/250 mg, od 21 do 58 µg/ml pri odmerku 500 mg/500 mg in od 41 do 83 µg/ml pri odmerku 1000 mg/1000 mg.
English: if you are allergic (hypersensitive) to imipenem, cilastatin or any of the other ingredients of TIENAM if you are allergic (hypersensitive) to other antibiotics such as penicillins, cephalosporins, or carbapenems
Slovenian: če ste alergični (preobčutljivi) na druge antibiotike, npr. peniciline, cefalosporine ali karbapeneme.
English: The AUC for imipenem following administration of 15/15 mg/kg per body weight of imipenem/cilastatin to paediatric patients was approximately 30% higher than the exposure in adults receiving a 500 mg/500 mg dose.
Slovenian: AUC za imipenem po uporabi imipenema/cilastatina v odmerku 15/15 mg/kg telesne mase je bila pri pediatričnih bolnikih približno za 30 % večja kot izpostavljenost pri odraslih, ki so dobili odmerek 500 mg/500 mg. Z večjim odmerkom je bila izpostavljenost po uporabi imipenema/cilastatina v odmerku 25/25 mg/kg pri otrocih za 9 % večja kot izpostavljenost odraslih, ki so dobili odmerek 1.000 mg/1.000 mg.
English: Antibiotic-associated colitis and pseudomembranous colitis have been reported with imipenem/cilastatin and with nearly all other anti-bacterial agents and may range from mild to life-threatening in severity.
Slovenian: Pri zdravljenu z imipenemom/cilastatinom in z skoraj vsemi drugimi protibakterijskimi zdravili so poročali o z antibiotikom povezanem kolitisu in psevdomembranoznem kolitisu, ki sta lahko blaga do smrtno nevarna.
English: 3: Inferred from cefoxitin susceptibility
Slovenian: 3: sklepanje temelji na podlagi občutljivosti za cefoksitin Enterococcus spp.
English: Urine concentrations of imipenem exceeded 10 g/ml for up to eight hours after a 500 mg/500 mg dose of TIENAM.
Slovenian: Koncentracija imipenema v urinu je po odmerku 500 mg/500 mg zdravila TIENAM presegala 10 g/ml do osem ur.
English: Uncommon hypotension
Slovenian: Občasni hipotenzija
English: Norway: Tienam
Slovenian: Norveška: Tienam
English: Estonia: TIENAM I.V.
Slovenian: Estonija: TIENAM I.V.
English: Imipenem-cilastatin sodium is haemodialyzable.
Slovenian: Imipenem in natrijeva sol cilastatina se hemodializirata.
English: Luxembourg: Tienam
Slovenian: Luksemburg: Tienam
English: For single use only.
Slovenian: Vsaka viala je samo za enkratno uporabo.
English: Peak plasma levels of cilastatin, following a 20 minute intravenous infusion of TIENAM, ranged from 21 to 26 μg/ml for the 250 mg/250 mg dose, from 21 to 55 μg/ml for the 500 mg/500 mg dose and from 56 to 88 μg/ml for the 1000 mg/1000 mg dose.
Slovenian: Največje koncentracije cilastatina v plazmi so bile po 20-minutnem intravenskem infundiranju zdravila TIENAM od 21 do 26 µg/ml pri odmerku 250 mg/250 mg, od 21 do 55 µg/ml pri odmerku 500 mg/500 mg in od 56 do 88 µg/ml pri odmerku 1000 mg/1000 mg.
English: It is recommended that the INR should be monitored frequently during and shortly after co-administration of antibiotics with an oral anti-coagulant agent.
Slovenian: Med sočasno uporabo antibiotikov in katerega od peroralnih antikoagulantov ter krajši čas po takšni uporabi je priporočljivo pogosto kontrolirati INR.
English: Belgium: Tienam
Slovenian: Belgija: Tienam
English: Hungary: Tienam
Slovenian: Madžarska: Tienam
English: Rare hearing loss
Slovenian: Redki poslabšanje sluha
English: Lithuania: TIENAM I.V.
Slovenian: Litva: TIENAM I.V.
English: Creatinine clearance (ml/min/1.73 m2)
Slovenian: očistek kreatinina (ml/min/1,73 m2) odmerek v mg (interval v urah)
English: • Enterobacteriaceae 1: S ≤2 mg/l, R >8 mg/l
Slovenian: Enterobacteriaceae 1: O ≤2 mg/l, R >8 mg/l
English: The concentration of the reconstituted solution following the above procedure is approximately 5 mg/ml for both imipenem and cilastatin.
Slovenian: Koncentracija imipenema in cilastatina v raztopini, pripravljeni po zgoraj opisanem postopku, je približno 5 mg/ml.
English: Sweden: Tienam
Slovenian: Švedska: Tienam
English: Hepatic impairment No dose adjustment is recommended in patients with impaired hepatic function (see section 5.2).
Slovenian: Okvara jeter Pri bolnikih z okvarjenim delovanjem jeter prilagoditve odmerka ne priporočamo (glejte poglavje 5.2).
English: Netherlands: TIENAM I.V.
Slovenian: Nizozemska: TIENAM I.V.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each vial contains: imipenem 500 mg and cilastatin 500 mg.
Slovenian: NAVEDBA ENE ALI VEČ ZDRAVILNIH UČINKOVIN Ena viala vsebuje: imipenem 500 mg in cilastatin 500 mg.
English: Common thrombophlebitis
Slovenian: Pogosti tromboflebitis
English: • Moraxalla catarrhalis 4: S ≤2 mg/l, R >2 mg/l
Slovenian: Moraxalla catarrhalis 4: O ≤2 mg/l, R >2 mg/l
English: Finland: TIENAM
Slovenian: Finska: TIENAM
English: • Haemophilus influenzae 4: S ≤2 mg/l, R >2 mg/l
Slovenian: Haemophilus influenzae 4: O ≤2 mg/l, R >2 mg/l
English: Hepatic
Slovenian: Hematologija
English: • Complicated infections in the abdomen
Slovenian: • zapleteno okužbo v trebuhu
English: Bulgaria: Tienam
Slovenian: Bolgarija: Tienam
English: Little absorption of either compound occurs following oral administration.
Slovenian: Po peroralni uporabi je absorpcija ene in druge učinkovine majhna.
English: The mean peak plasma levels of imipenem following the 250 mg/250 mg, 500 mg/500 mg, and 1000 mg /1000 mg doses were 17, 39, and 66 μg/ml, respectively.
Slovenian: Povprečna največja koncentracija imipenema v plazmi je bila po odmerku 250 mg/250 mg 17 µg/ml, po odmerku 500 mg/500 mg 39 µg/ml in po odmerku 1000 mg/1000 mg 66 µg/ml.
English: Method of administration
Slovenian: Mehanizem odpornosti
English: Poland: TIENAM
Slovenian: Poljska: TIENAM
English: There is no dose adjustment necessary (see section
Slovenian: Prilagoditev odmerka ni potrebna (glejte poglavje 4.2).
English: What TIENAM contains - The active substances are imipenem and cilastatin.
Slovenian: Zdravilni učinkovini sta imipenem in cilastatin.
English: Therefore, no dose adjustment is recommended in patients with hepatic impairment (see section 4.2).
Slovenian: Zato bolnikom z okvaro jeter odmerka ni treba prilagoditi (glejte poglavje 4.2).
English: The mean peak plasma levels of cilastatin following the 250 mg/250 mg, 500 mg/500 mg, and 1000 mg/1000 mg doses were 22, 42, and 72 µg/ml respectively.
Slovenian: Povprečna največja koncentracija cilastatina v plazmi je bila po odmerku 250 mg/250 mg 22 µg/ml, po odmerku 500 mg/500 mg 42 µg/ml in po odmerku 1000 mg/1000 mg 72 µg/ml.
English: Streptococcus viridans group
Slovenian: Skupina Streptococcus viridans Gramnegativni aerobi:
English: Each vial contains imipenem monohydrate equivalent to 500 mg imipenem anhydrate and cilastatin sodium equivalent to 500 mg cilastatin.
Slovenian: Ena viala vsebuje 500 mg imipenema v obliki imipenem monohidrata in 500 mg cilastatina v obliki natrijevega cilastatinata.
English: Nausea and vomiting appear to occur more frequently in patients with low number of white blood cells
Slovenian: Pogosti siljenje na bruhanje, bruhanje, driska; siljenje na bruhanje in bruhanje sta pogostejša pri bolnikih z majhnim številom belih krvnih celic oteklost in pordelost vzdolž vene, ki je izredno občutljiva na dotik izpuščaj nenormalno delovanje jeter, ki ga pokažejo preiskave krvi povečanje števila nekaterih belih krvnih celic
English: No accumulation of imipenem in plasma or urine has been observed with regimens of TIENAM, administered as frequently as every six hours, in patients with normal renal function.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic niso ugotovili kopičenja imipenema v plazmi ali urinu niti med uporabo zdravila TIENAM na šest ur.