FrancophonIA/ELRC3.0 huggingface dataset:
English: It is thought that people who are depressed and/or anxious have lower levels of serotonin and noradrenaline in the brain.
Slovenian: Menijo, da imajo ljudje, ki so depresivni in/ali anksiozni, nižje vrednosti serotonina in noradrenalina v možganih.
English: Your doctor should decide whether you can take Efexor with other medicines.
Slovenian: Vaš zdravnik bo presodil, ali lahko jemljete zdravilo Efexor skupaj z drugimi zdravili.
English: Animal studies regarding reproductive toxicity have found in rats a decrease in pup weight, an increase in stillborn pups, and an increase in pup deaths during the first 5 days of lactation.
Slovenian: V raziskavah toksičnosti za razmnoževanje na živalih so pri podganah ugotovili zmanjšano maso mladičev, povečanje števila mrtvorojenih mladičev in pogostnejšo smrt mladičev v prvih 5 dneh dojenja.
English: Concomitant administration of venlafaxine and metoprolol to healthy volunteers in a pharmacokinetic interaction study for both medicinal products resulted in an increase of plasma concentrations of metoprolol by approximately 30-40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol.
Slovenian: Pri sočasni uporabi venlafaksina in metoprolola v raziskavi farmakokinetičnih interakcij za obe zdravili pri zdravih prostovoljcih, so se plazemske koncentracije metoprolola povišale za približno 30-40 % brez sprememb plazemskih koncentracij njegovega aktivnega presnovka α-hidroksimetoprolola.
English: Discontinuation of venlafaxine (particularly when abrupt) commonly leads to withdrawal symptoms.
Slovenian: Ukinitev venlafaksina (še posebej nenadna) pogosto povzroči odtegnitvene simptome.
English: • If you use other medicines that taken concomitantly with Efexor could increase the risk of developing serotonin syndrome (see the section “Taking other medicines”).
Slovenian: • če jemljete druga zdravila, ki bi lahko pri sočasni uporabi z zdravilom Efexor povečala tveganje za nastanek serotoninskega sindroma (glejte poglavje “Jemanje drugih zdravil”);
English: Use in children and adolescents under the age of 18 years
Slovenian: Uporaba pri otrocih in mladostnikih, mlajših od 18 let
English: Patients with a history of suicide-related events, or those exhibiting a significant degree of suicidal ideation prior to commencement of treatment, are known to be at greater risk of suicidal thoughts or suicide attempts, and should receive careful monitoring during treatment.
Slovenian: Znano je, da pri bolnikih s samomorom povezanimi dogodki v anamnezi, ali bolnikih, ki kažejo znatno stopnjo samomorilne miselnosti pred uvedbo zdravljenja, obstaja večje tveganje za pojav samomorilnih misli ali poskusov samomora in jih je treba med zdravljenjem skrbno spremljati.
English: The clinical relevance of this finding in hypertensive patients is unknown.
Slovenian: Klinični pomen te ugotovitve pri hipertenzivnih bolnikih ni znan.
English: • Swelling of the face, throat, hands, or feet
Slovenian: • otekanje obraza, grla, dlani ali stopal;
English: Not known: swollen face or tongue, shortness of breath or difficulty breathing, often with skin rashes (this may be a serious allergic reaction)
Slovenian: Neznana: otekel obraz ali jezik, kratka sapa ali oteženo dihanje, pogosto s kožnimi izpuščaji (to je lahko resna alergijska reakcija)
English: General supportive and symptomatic measures are recommended; cardiac rhythm and vital signs must be monitored.
Slovenian: Spremljati je treba srčni ritem in vitalne znake.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redkimi dednimi težavami, kot so intoleranca za galaktozo, laponska oblika zmanjšane aktivnosti laktaze ali malabsorpcija glukoze/galaktoze, tega zdravila ne smejo jemati.
English: You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet.
Slovenian: Morda bi bilo koristno, če za težave z depresijo ali anksioznostjo poveste sorodniku ali dobremu prijatelju in ga prosite, da prebere to navodilo.
English: Controlled clinical studies in children and adolescents with major depressive disorder failed to demonstrate efficacy and do not support the use of venlafaxine in these patients (see sections 4.4 and
Slovenian: V nadzorovanih kliničnih raziskavah pri otrocih in mladostnikih s hudo depresivno motnjo učinkovitost ni bila dokazana, tako da raziskave ne podpirajo uporabe venlafaksina pri teh bolnikih (glejte poglavji 4.4 in 4.8).
English: • If you have a tendency to develop bruises or a tendency to bleed easily (history of bleeding disorders), or if you are taking other medicines that may increase the risk of bleeding.
Slovenian: • če ste nagnjeni k nastajanju modric ali k nastajanju krvavitev (bolezni s krvavitvami v anamnezi) ali če jemljete druga zdravila, ki lahko povečajo tveganje za nastanek krvavitve;
English: This should be taken into account in patients treated with haloperidol and venlafaxine concomitantly.
Slovenian: To je treba upoštevati pri bolnikih, ki se sočasno zdravijo s haloperidolom in venlafaksinom.
English: The dose can be raised by your doctor gradually and, if needed, even up to a maximum dose of 375 mg daily for depression.
Slovenian: Po potrebi lahko zdravnik odmerek postopoma zvišuje, tudi do največjega odmerka 375 mg na dan pri zdravljenju depresije.
English: In postmarketing experience, overdose with venlafaxine was reported predominantly in combination with alcohol and/or other medicinal products.
Slovenian: Pri spremljanju zdravila med trženjem so o prevelikem odmerjanju venlafaksina poročali predvsem v kombinaciji z alkoholnimi pijačami in/ali drugimi zdravili.
English: More rarely, Efexor may reduce the function of platelets in your blood, leading to an increased risk of bruising or bleeding.
Slovenian: Redkeje lahko zdravilo Efexor zmanjša delovanje krvnih ploščic v vaši krvi, kar lahko poveča tveganje za nastanek modric ali krvavitev.
English: Like all medicines, Efexor can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Efexor neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Taking an irreversible MAOI together with other medicines, including Efexor, can cause serious or even life-threatening side effects.
Slovenian: Uporaba ireverzibilnega zaviralca MAO skupaj z drugimi zdravili, vključno z zdravilom Efexor, lahko povzroči resne ali celo življenjsko nevarne neželene učinke.
English: Venlafaxine has been shown not to increase the impairment of mental and motor skills caused by ethanol.
Slovenian: Izkazalo se je, da venlafaksin ne povečuje motenj duševnih in motoričnih funkcij, ki jih povzroča etanol.
English: Dosage adjustment is necessary in patients with severe renal impairment and in patients that require haemodialysis (see section 4.2).
Slovenian: Prilagajanje odmerjanja je potrebno pri bolnikih s hudimi okvarami ledvic in pri bolnikih, pri katerih je potrebna hemodializa (glejte poglavje 4.2).
English: Although no change in dosage is necessary for patients with glomerular filtration rate (GFR) between 30-70 ml/minute, caution is advised.
Slovenian: Čeprav pri bolnikih s hitrostjo glomerulne filtracije (GFR) med 30 in 70 ml/min ni potrebno prilagajanje odmerjanja, je priporočljiva previdnost.
English: • Muscle disorders Not known: unexplained muscle pain, tenderness or weakness (rhabdomyolysis)
Slovenian: • Bolezni mišic Neznana: nepojasnjene bolečine v mišicah, občutljivost ali oslabelost (rabdomioliza)
English: SPC Section 4.5 - Interaction with other medicinal products and other forms of interaction
Slovenian: 4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij
English: Because of the risk of dose-related adverse effects, dose increments should be made only after a clinical evaluation (see section 4.4).
Slovenian: Zaradi tveganja pojava neželenih učinkov, ki so odvisni od odmerka, se sme odmerek zviševati samo po klinični presoji (glejte poglavje 4.4).
English: The SPC was amended according to the CHMP position.
Slovenian: Povzetek glavnih značilnosti zdravila je bil spremenjen v skladu s stališčem CHMP.
English: In patients with mild and moderate hepatic impairment, in general a 50% dose reduction should be considered.
Slovenian: Pri bolnikih z blago in zmerno okvaro jeter je v splošnem priporočljivo razmisliti o zmanjšanju odmerka za 50 %.
English: The mechanism of venlafaxine's antidepressant action in humans is believed to be associated with its potentiation of neurotransmitter activity in the central nervous system.
Slovenian: Menijo, da je mehanizem antidepresivnega delovanja venlafaksina pri ljudeh povezan z okrepitvijo aktivnosti nevrotransmiterjev v osrednjem živčevju.
English: Some newborns exposed to venlafaxine late in the third trimester have developed complications requiring tube-feeding, respiratory support or prolonged hospitalisation.
Slovenian: Pri nekaterih novorojenčkih, ki so bili pozno v tretjem trimesečju nosečnosti izpostavljeni venlafaksinu, so se pojavili zapleti, ki so zahtevali hranjenje po sondi, dihalno podporo ali podaljšano zdravljenje v bolnišnici.
English: • Metoprolol (a beta blocker to treat high blood pressure and heart problems)
Slovenian: • metoprolol (blokator adrenergičnih beta receptorjev, ki se uporablja za zdravljenje zvišanega krvnega tlaka in bolezni srca).
English: If clinically warranted due to symptom severity, dose increases can be made at more frequent intervals, but not less than 4 days.
Slovenian: Če je zaradi stopnje izraženosti simptomov klinično upravičeno, se lahko odmerek zvišuje tudi pogosteje, vendar presledki med odmerki ne smejo biti krajši od 4 dni.
English: Do not use Efexor after the expiry date, which is stated on the packaging.
Slovenian: Zdravila Efexor ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini.
English: The use of venlafaxine has been associated with the development of akathisia, characterised by a subjectively unpleasant or distressing restlessness and need to move often accompanied by an inability to sit or stand still.
Slovenian: Uporaba venlafaksina je bila povezana z razvojem akatizije, za katero sta značilna subjektivno neprijeten ali mučen nemir in potreba po gibanju, ki jo pogosto spremlja bolnikova nezmožnost, da bi mirno sedel ali stal.
English: If you are taking Efexor during pregnancy, let your midwife and/or doctor know as your baby might have some symptoms when it is born.
Slovenian: Če jemljete zdravilo Efexor med nosečnostjo, o tem obvestite babico in/ali zdravnika, ker se lahko tudi pri vašem otroku po rojstvu pojavijo odtegnitveni simptomi.
English: Your doctor will advise you on how you should gradually discontinue Efexor treatment.
Slovenian: Zdravnik vam bo svetoval, kako postopoma ukinete zdravljenje z zdravilom Efexor.
English: This medicinal product is authorised in the Member States of the EEA under the following names:
Slovenian: Zdravilo je v državah članicah EGP pridobilo dovoljenje za promet z naslednjimi imeni: Avstrija
English: It is recommended that venlafaxine immediate-release tablets be taken with food, at approximately the same time each day.
Slovenian: Priporočljivo je, da bolnik venlafaksin v obliki tablet s takojšnjim sproščanjem jemlje skupaj s hrano, vsak dan ob približno istem času.
English: However, caution should be exercised in treating the elderly (e.g., due to the possibility of renal impairment, the potential for changes in neurotransmitter sensitivity and affinity occurring with aging).
Slovenian: Vendar pa je pri zdravljenju starejših bolnikov potrebna previdnost (npr. zaradi možnosti ledvične okvare, možnih sprememb občutljivosti in afinitete za nevrotransmiterje, ki se pojavijo pri staranju).
English: Venlafaxine did not inhibit CYP1A2, CYP2C9, or CYP3A4.
Slovenian: Venlafaksin ne inhibira CYP1A2, CYP2C9 ali CYP3A4.
English: If concomitant treatment of venlafaxine with an SSRI, an SNRI or a serotonin receptor agonist (triptan) is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.
Slovenian: Če je sočasno zdravljenje z venlafaksinom in SSRI, SNRI ali agonisti serotoninskih receptorjev (triptan) klinično upravičeno, je priporočljivo bolnika skrbno nadzirati, še posebej med uvodnim obdobjem zdravljenja in pri zviševanju odmerkov.
English: Administration of activated charcoal may also limit absorption of the active substance.
Slovenian: Absorpcija zdravilne učinkovine se lahko zmanjša tudi z uporabo aktivnega oglja.
English: A pharmacokinetic study with haloperidol has shown a 42% decrease in total oral clearance, a 70% increase in AUC, an 88% increase in Cmax, but no change in half-life for haloperidol.
Slovenian: Farmakokinetična raziskava s haloperidolom je pokazala 42-odstotno zmanjšanje celokupnega peroralnega očistka, 70-odstotno povečanje AUC, 88-odstotno povišanje Cmax, a nikakršne spremembe razpolovnega časa haloperidola.
English: Use in elderly patients: based on published data raising the possibility of renal impairment and the potential for changes in neurotransmitter sensitivity and affinity with aging, a new wording for use in elderly patients was agreed in the SPC.
Slovenian: Uporaba pri starejših bolnikih: na podlagi objavljenih podatkov o povečanju možnosti okvare ledvic ter sprememb občutljivosti in afinitete živčnih prenašalcev, je bilo v povzetku glavnih značilnosti zdravila sprejeto novo besedilo za uporabo pri starejših bolnikih.
English: In vitro studies revealed that venlafaxine has virtually no affinity for opiate or benzodiazepine sensitive receptors.
Slovenian: In vitro raziskave so pokazale, da venlafaksin praktično nima afinitete za receptorje, občutljive za opiate ali benzodiazepine.
English: Approximately 87% of a venlafaxine dose is recovered in the urine within 48 hours as either unchanged venlafaxine (5%), unconjugated ODV (29%), conjugated ODV (26%), or other minor inactive metabolites (27%).
Slovenian: V 48 urah se z urinom izloči približno 87 % odmerka venlafaksina, in sicer v obliki nespremenjenega venlafaksina (5 %), nekonjugiranega ODV (29 %), konjugiranega ODV (26 %) in drugih, manj pomembnih neaktivnih presnovkov (27 %).
English: Following treatment with a reversible MAO-inhibitor, a shorter withdrawal period than 14 days may be used before initiation of venlafaxine treatment.
Slovenian: Po zdravljenju z reverzibilnim zaviralcem MAO je lahko odtegnitveno obdobje pred uvedbo zdravljenja z venlafaksinom krajše od 14 dni.
English: Epidemiological studies have shown that venlafaxinetreated patients have a higher burden of suicide risk factors than SSRI patients.
Slovenian: Epidemiološke raziskave so pokazale, da so z venlafaksinom zdravljeni bolniki bolj obremenjeni z dejavniki tveganja za samomor kot bolniki, ki se zdravijo s SSRI.
English: They include not feeding properly and trouble with breathing.
Slovenian: Vključujejo motnje hranjenja novorojenčka in težave z dihanjem.
English: If you experience any of these or other symptoms that are troublesome, ask your doctor for further advice.
Slovenian: Če opazite katerega od teh simptomov ali kakšne druge simptome, ki jih občutite kot neznosne, prosite zdravnika za nasvet.
English: The most commonly (>1/10) reported adverse reactions in clinical studies were nausea, dry mouth, headache and sweating (including night sweats).
Slovenian: Neželeni učinki, o katerih so v kliničnih raziskavah najpogosteje (>1/10) poročali, so bili navzea, suha usta, glavobol in znojenje (vključno z napadi nočnega znojenja).
English: When equal daily doses of venlafaxine are administered as either an immediate-release tablet or prolonged-release capsule, the prolonged-release capsule provides a slower rate of absorption, but the same extent of absorption compared with the immediate-release tablet.
Slovenian: Pri uporabi enakih dnevnih odmerkov venlafaksina v obliki tablet s takojšnjim sproščanjem in v obliki kapsul s podaljšanim sproščanjem, je pri kapsulah s podaljšanim sproščanjem hitrost absorpcije manjša, obseg absorpcije pa enak obsegu absorpcije pri tabletah s takojšnjim sproščanjem.
English: Age and gender Subject age and gender do not significantly affect the pharmacokinetics of venlafaxine and ODV.
Slovenian: Starost in spol Starost in spol preiskovancev ne vplivata pomembno na farmakokinetiko venlafaksina in ODV.
English: What Efexor is and what is used for Before you take Efexor How to take Efexor Possible side effects How to store Efexor Further information
Slovenian: Kaj je zdravilo Efexor in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Efexor Kako jemati zdravilo Efexor Možni neželeni učinki
English: Venlafaxine increased the risperidone AUC by 50%, but did not significantly alter the pharmacokinetic profile of the total active moiety (risperidone plus 9-hydroxyrisperidone).
Slovenian: Venlafaksin je za 50 % povečal AUC risperidona, ni pa značilno spremenil farmakokinetičnega profila obeh aktivnih snovi (risperidona in 9-hidroksirisperidona).
English: Withdrawal symptoms when treatment is discontinued are common, particularly if discontinuation is abrupt (see section 4.8).
Slovenian: Pri prekinitvi zdravljenja so odtegnitveni učinki pogosti, še posebej, če je prekinitev nenadna (glejte poglavje 4.8).
English: These symptoms may be due to either serotonergic effects or exposure symptoms.
Slovenian: Ti simptomi so lahko posledica serotoninergičnih učinkov ali učinkov izpostavljenosti venlafaksinu.
English: Effect of venlafaxine on other medicinal products
Slovenian: Delovanje venlafaksina na druga zdravila
English: [See Annex I - To be completed nationally]
Slovenian: [Glejte Dodatek I - Izpolni država članica.]
English: It is recommended that patients with raised intraocular pressure or patients at risk for acute narrow-angle glaucoma (angle-closure glaucoma) be closely monitored.
Slovenian: Priporočljivo je, da se bolnike z zvišanim intraokularnim tlakom ali s tveganjem za akutni glavkom z ozkim zakotjem (glavkom z zaprtim zakotjem) skrbno nadzoruje.
English: Efexor should be taken with food (see section 3 “HOW TO TAKE EFEXOR”).
Slovenian: Zdravilo Efexor je treba jemati skupaj s hrano (glejte poglavje 3 “KAKO JEMATI ZDRAVILO EFEXOR”).
English: Concomitant use of CYP3A4 inhibitors (e.g., atazanavir, clarithromycin, indinavir, itraconazole, voriconazole, posaconazole, ketoconazole, nelfinavir, ritonavir, saquinavir, telithromycin) and venlafaxine may increase levels of venlafaxine and O-desmethylvenlafaxine.
Slovenian: Pri sočasni uporabi zaviralcev CYP3A4 (kakršni so npr. atazanavir, klaritromicin, indinavir, itrakonazol, vorikonazol, posakonazol, ketokonazol, nelfinavir, ritonavir, sakvinavir, telitromicin) in venlafaksina se lahko povišajo vrednosti venlafaksina in O-demetilvenlafaksina.
English: • Ketoconazole (an antifungal medicine)
Slovenian: • ketokonazol (protiglivično zdravilo),
English: The safety and efficacy of venlafaxine therapy in combination with weight loss agents, including phentermine, have not been established.
Slovenian: Varnosti in učinkovitosti zdravljenja z venlafaksinom v kombinaciji s sredstvi za hujšanje, vključno s fenterminom, niso ugotovili.
English: You should tell your doctor if this happens to you.
Slovenian: Če se vam to zgodi, morate to povedati svojemu zdravniku.
English: The concomitant use of venlafaxine with serotonin precursors (such as tryptophan supplements) is not recommended (see section 4.4).
Slovenian: Sočasna uporaba venlafaksina in prekurzorjev serotonina (kot so nadomestki triptofana) ni priporočljiva (glejte poglavje 4.4).
English: Ketoconazole (CYP3A4 inhibitor)
Slovenian: Ketokonazol (zaviralec CYP3A4)
English: Withdrawal symptoms seen on discontinuation of venlafaxine: based on a proposed text for the SPC for Selective Serotonin Reuptake Inhibitors (SSRIs) / Selective Norepinephrine Reuptake Inhibitors (SNRIs) (Sections 4.2, 4.4, and 4.8) reviewed by the Pharmacovigilance Working Party, it was agreed to incorporate this text into the harmonised SPC.
Slovenian: Odtegnitveni simptomi ob prenehanju jemanja venlafaksina: na podlagi predlaganega besedila za povzetek glavnih značilnosti zdravila za selektivne zaviralce ponovnega prevzema serotonina (SSRI)/zaviralce ponovnega prevzema serotonina in noradrenalina (SNRI) (poglavja 4.2, 4.4 in 4.8), ki ga je proučila delovna skupina za farmakovigilanco, je bilo dogovorjeno, da se to besedilo vključi v usklajeni povzetek glavnih značilnosti o zdravilu.
English: The recommended starting dose of immediate-release venlafaxine is 75 mg/day in two or three divided doses taken with food.
Slovenian: Priporočeni začetni odmerek venlafaksina s takojšnjim sproščanjem je 75 mg na dan, v dveh ali treh razdeljenih odmerkih, ki jih je treba vzeti s hrano.
English: Venlafaxine must not be used in combination with irreversible non-selective MAOIs.
Slovenian: Venlafaksina se ne sme uporabljati v kombinaciji z ireverzibilnimi neselektivnimi zaviralci MAO.
English: A warning on the use of Efexor in the treatment of children and adolescents under the age of 18 years was also agreed upon and introduced in Section 4.4.
Slovenian: Sprejeto je bilo tudi opozorilo glede uporabe zdravila Efexor pri zdravljenju otrok in mladostnikov, mlajših od 18 let, in je bilo vključeno v poglavje 4.4 povzetka glavnih značilnosti zdravila.
English: Do not take more than the daily amount of Efexor that has been prescribed for you in one day.
Slovenian: V enem dnevu ne smete vzeti več zdravila Efexor, kot vam ga je zdravnik predpisal za en dan.
English: FURTHER INFORMATION What Efexor contains The active substance is venlafaxine.
Slovenian: DODATNE INFORMACIJE Kaj vsebuje zdravilo Efexor Zdravilna učinkovina je venlafaksin.
English: Use in patients with renal impairment: it was agreed that the individualisation of the dosage may be desirable, and this concept was introduced in the text for harmonisation.
Slovenian: Uporaba pri bolnikih z okvaro ledvic: sprejeto je bilo, da je zaželeno določanje odmerka za vsakega bolnika posebej, to priporočilo pa je bilo vključeno v usklajeno besedilo.
English: Withdrawal symptoms seen on discontinuation of venlafaxine
Slovenian: Odtegnitveni simptomi pri prekinitvi zdravljenja z venlafaksinom
English: Also, you must wait at least 7 days after you stop taking Efexor before you take any irreversible MAOI (see also the sections “Serotonin syndrome” and “Taking other medicines”).
Slovenian: Po prekinitvi jemanja zdravila Efexor morate počakati vsaj 7 dni, preden začnete uporabljati katerikoli ireverzibilen zaviralec MAO (glejte tudi poglavji “Serotoninski sindrom” in “Jemanje drugih zdravil”).
English: • Severe rash, itching, or hives (elevated patches of red or pale skin that often itch)
Slovenian: • hud izpuščaj, srbenje ali koprivnica (povečanje rdeče ali bele pege na koži, ki pogosto srbi).
English: **Cases of suicidal ideation and suicidal behaviours have been reported during venlafaxine therapy or early after treatment discontinuation (see section 4.4).
Slovenian: ** Med zdravljenjem z venlafaksinom ali kmalu po prekinitvi zdravljenja so poročali o primerih samomorilne miselnosti in samomorilnega vedenja (glejte poglavje 4.4).
English: When stopping treatment with venlafaxine, the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions (see sections 4.4 and 4.8).
Slovenian: V primeru prekinitve zdravljenja z venlafaksinom je treba odmerek zniževati postopoma vsaj en teden do dva tedna, da se zmanjša nevarnost odtegnitvenih učinkov (glejte poglavji 4.4 in 4.8).
English: The extent to which the finding of an increased risk of fatal outcomes can be attributed to the toxicity of venlafaxine in overdosage, as opposed to some characteristics of venlafaxine-treated patients, is not clear.
Slovenian: Ni jasno, v kakšni meri je večje tveganje za smrtne izide posledica toksičnosti prevelikih odmerkov venlafaksina in v kakšni meri posledica nekaterih značilnosti z venlafaksinom zdravljenih bolnikov.