FrancophonIA/ELRC3.0 huggingface dataset:
English: Presumably through blockade of the renin-angiotensin-aldosterone system, co-administration of telmisartan tends to reverse the potassium loss associated with these diuretics.
Croatian: Pretpostavlja se da putem blokade sustava renin-angiotenzin-aldosteron, istodobna primjena telmisartana ima tendenciju vraćanja gubitka kalija povezanog s ovim diureticima.
English: Tolucombi is not indicated in patients with severe hepatic impairment.
Croatian: Tolucombi nije indiciran kod bolesnika s teškim oštećenjem jetrene funkcije.
English: Visual disturbance, vision blurred
Croatian: poremećaj vida, zamućeni vid
English: Endocrine disorders Not known: Diabetes mellitus inadequate control
Croatian: Endokrini poremećaji Nepoznato: neodgovarajuća kontrola dijabetes melitusa
English: Immune system disorders Not known: Anaphylactic reactions, hypersensitivity
Croatian: Poremećaji imunološkog sustava Nepoznato: anafilaktičke reakcije, preosjetljivost
English: Do not take Tolucombi: - if you are allergic to telmisartan or any other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati Tolucombi - ako ste alergični na telmisartan ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.). - ako ste alergični na hidroklorotiazid ili neki od drugih derivata sulfonamida.
English: - The other ingredients are: hydroxypropylcellulose, lactose monohydrate, magnesium stearate, mannitol, meglumine, povidone (K30), red ferric oxide (E172) - only in 40 mg/12.5 mg and 80 mg/12.5 mg tablets, silica colloidal anhydrous, sodium hydroxide (E524), sodium stearyl fumarate, sorbitol (E420) and yellow ferric oxide (E172) - only in 80 mg/25 mg tablets.
Croatian: - Drugi sastojci su hidroksipropilceluloza, laktoza hidrat, magnezijev stearat, manitol, meglumin, povidon (K30), crveni željezov oksid (E172) - samo u tabletama od 40 mg/12,5 mg i 80 mg/12,5 mg, silicijev dioksid koloidni, bezvodni, natrijev hidroksid (E524), natrijev stearilfumarat, sorbitol (E420) i žuti željezov oksid (E172) - samo u tabletama od 80 mg/25 mg.
English: Such conditions should be corrected before the administration of Tolucombi.
Croatian: Takva stanja moraju se korigirati prije primjene lijeka Tolucombi.
English: If the dates for submission of a PSUR and the update of a RMP coincide, they can be submitted at the same time.
Croatian: Ako se rokovi podnošenja periodičkog izvješća o neškodljivosti (PSUR) podudaraju s nadopunama Plana upravljanja rizikom (RMP), dokumenti mogu biti podneseni istodobno.
English: In patients with mild to moderate hepatic impairment the posology should not exceed Tolucombi 40 mg/12.5 mg once daily.
Croatian: Kod bolesnika s blagim do umjerenim oštećenjem jetrene funkcije doza lijeka Tolucombi ne smije prelaziti 40 mg/12,5 mg jedanput dnevno.
English: No clear evidence of a teratogenic effect was observed, however at toxic dose levels of telmisartan an effect on the postnatal development of the offsprings such as lower body weight and delayed eye opening was observed.
Croatian: Međutim, pri toksičnim dozama telmisartana, primijećeni su učinci na postnatalni razvoj legla, kao što su smanjena tjelesna težina i odgođeno otvaranje očiju.
English: Abnormal hepatic function/liver disorder
Croatian: abnormalna jetrena funkcija/poremećaj jetre
English: Telmisartan In patients taking telmisartan alone the following additional side effects have been reported:
Croatian: Telmisartan Kod bolesnika koji uzimaju monoterapiju telmisartana prijavljene su sljedeće nuspojave:
English: Cytotoxic agents (e.g. cyclophosphamide, methotrexate) Thiazides may reduce the renal excretion of cytotoxic medicinal products and potentiate their myelosuppressive effects.
Croatian: Citotoksični lijekovi (npr. ciklofosfamid, metotreksat) Tiazidi mogu reducirati renalnu ekskreciju citotoksičnih lijekova i potencirati njihove mijelosupresivne učinke.
English: - Renal artery stenosis (narrowing of the blood vessels to one or both kidneys).
Croatian: - Stenoza bubrežne arterije (sužavanje krvnih žila koje vode u jedan ili oba bubrega).
English: Toxicological findings also well known from preclinical studies with angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists were: a reduction of red cell parameters (erythrocytes, haemoglobin, haematocrit), changes of renal haemodynamics (increased blood urea nitrogen and creatinine), increased plasma renin activity, hypertrophy/hyperplasia of the juxtaglomerular cells and gastric mucosal injury.
Croatian: Toksikološki nalazi, također dobro poznati iz pretkliničkih studija s inhibitorima enzima koji pretvara angiotenzin i s antagonistima receptora angiotenzina II, bili su: smanjenje parametara crvenih krvnih stanica (eritrociti, hemoglobin, hematokrit), promjene u bubrežnoj hemodinamici (povišeni dušik iz uree u krvi (BUN) i kreatinin), povećana aktivnost renina u plazmi, hipertrofija/hiperplazija jukstaglomerularnih stanica i ozljeda želučane sluznice.
English: Angiotensin II is a substance produced in your body which causes your blood vessels to narrow thus increasing your blood pressure.
Croatian: Angiotenzin II je tvar koja se proizvodi u organizmu, a dovodi do sužavanja krvnih žila i na taj način povišenja krvnog tlaka.
English: Abdominal pain, constipation,dyspepsia, vomiting, gastritis
Croatian: bol u abdomenu, konstipacija, dispepsija, povraćanje, gastritis
English: There is no experience regarding the administration of Tolucombi in patients with recent kidney transplantation.
Croatian: Ne postoji iskustvo glede primjene lijeka Tolucombi kod bolesnika s nedavno presađenim bubregom.
English: When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started.
Croatian: Kada se trudnoća dijagnosticira, liječenje antagonistima receptora angiotenzina II mora se odmah prekinuti te, prema potrebi, početi sa zamjenskom terapijom.
English: - Medicines for the treatment of diabetes (insulins or oral agents such as metformin).
Croatian: - Lijekovi za liječenje dijabetesa (inzulini ili lijekovi koji se primjenjuju kroz usta kao što je metformin).
English: Tolucombi is a combination of an angiotensin II receptor antagonist, telmisartan, and a thiazide diuretic, hydrochlorothiazide.
Croatian: Tolucombi je kombinacija antagonista receptora angiotenzina II, telmisartana, i tiazidskog diuretika, hidroklorotiazida.
English: Cases of interstitial lung disease have been reported from post-marketing experience in temporal association with the intake of telmisartan.
Croatian: Slučajevi intersticijske bolesti pluća prijavljeni su iz iskustva tijekom razdoblja nakon stavljanja lijeka u promet, a u vremenskoj su vezi s unosom telmisartana.
English: - Other medicines used to treat high blood pressure, corticosteroids, painkillers (such as nonsteroidal anti-inflammatory drugs [NSAIDs]), medicines to treat cancer, gout, or arthritis.
Croatian: - Drugi lijekovi koji se primjenjuju u liječenju visokog krvnog tlaka, kortikosteroidi, lijekovi protiv bolova (kao što su nesteroidni protuupalni lijekovi [NSAIL-i]), lijekovi za liječenje raka, gihta, ili artritisa.
English: Adverse reactions reported with one of the individual components may be potential adverse reactions with Tolucombi, even if not observed in clinical trials with this product.
Croatian: Nuspojave prijavljene uz jednu od pojedinih komponenti mogu biti potencijalne nuspojave uz Tolucombi, čak ako i nisu primijećene u kliničkim ispitivanjima s ovim lijekom.
English: Medicinal products associated with potassium loss and hypokalaemia (e.g. other kaliuretic diuretics, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G sodium, salicylic acid and derivatives).
Croatian: Lijekovi povezani s gubitkom kalija i hipokalemijom (npr. drugi kalijuretički diuretici, laksativi, kortikosteroidi, ACTH, amfotericin, karbenoksolon, penicilin G natrij, salicilatna kiselina i derivati)
English: Exposure to angiotensin II receptor antagonist therapy during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (See section 5.3).
Croatian: Poznato je da izloženost terapiji antagonistom receptora angiotenzina II tijekom drugog i trećeg tromjesečja inducira fetotoksičnost u ljudi (smanjena bubrežna funkcija, oligohidramnion, kašnjenje osifikacije lubanje) kao i neonatalnu toskičnost (zatajenje bubrega, hipotenzija, hiperkalemija) (vidjeti dio 5.3).
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Croatian: Ostali izvori informacija Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: No statistically significant difference in the incidence of the primary composite endpoint (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for congestive heart failure) was found [15.7 % in the telmisartan and 17.0 % in the placebo groups with a hazard ratio of 0.92 (95 % CI 0.81 - 1.05, p = 0.22)].
Croatian: Nije pronađena statistički značajna razlika u incidenciji primarnog kompozitnog ishoda (kardiovaskularna smrt, nefatalni infarkt miokarda, nefatalni moždani udar ili hospitalizacija zbog kongestivnog zatajenja srca) [15,7% u skupini na telmisartanu i 17,0% u skupini na placebu, s omjerom rizika od 0,92 (95% CI 0,81 - 1,05, p = 0,22)].
English: Uncommon: Blood uric acid increased Rare:
Croatian: Manje često: povišene vrijednosti mokraćne kiseline u krvi Rijetko:
English: Gastric lesions could be prevented/ameliorated by oral sodium chloride solution supplementation and group housing of animals.
Croatian: Gastrične lezije mogu se spriječiti/ ublažiti oralnim nadomjescima otopine natrijevog klorida i grupnim smještanjem životinja.
English: How to take Tolucombi
Croatian: Kako uzimati Tolucombi
English: Common side effects (may affect up to 1 in 10 people): Dizziness.
Croatian: Česte nuspojave (mogu se javiti u do 1 na 10 osoba): Omaglica.
English: Psychiatric disorders Uncommon: Anxiety Rare:
Croatian: Psihijatrijski poremećaji Manje često: anksioznost Rijetko:
English: Eye disorders Not known: Xanthopsia, acute myopia, acute angle-closure glaucoma
Croatian: Poremećaji oka Nepoznato: ksantopsija, akutna miopija, akutni glaukom zatvorenog kuta
English: Psychiatric disorders Not known: Restlessness
Croatian: Psihijatrijski poremećaji Nepoznato: nemir
English: Cardiac disorders Uncommon: Bradycardia
Croatian: Srčani poremećaji Manje često: bradikardija
English: Other conditions with stimulation of the renin-angiotensin-aldosterone system In patients whose vascular tone and renal function depend predominantly on the activity of the renin-angiotensin-aldosterone system (e.g. patients with severe congestive heart failure or underlying renal disease, including renal artery stenosis), treatment with medicinal products that affect this system has been associated with acute hypotension, hyperazotaemia, oliguria, or rarely acute renal failure (see section 4.8).
Croatian: Ostala stanja sa stimulacijom renin-angiotenzin-aldosteronskog sustava Kod bolesnika čiji vaskularni tonus i bubrežna funkcija ovise uglavnom o aktivnosti sustava reninangiotenzin-aldosteron (npr. bolesnici s teškim kongestivnim zatajenjem srca ili oni s postojećom bubrežnom bolesti, uključujući stenozu bubrežne arterije), liječenje lijekovima koji utječu na ovaj sustav povezano je s akutnom hipotenzijom, hiperazotemijom, oligurijom, ili rijetko akutnim zatajenjem bubrega (vidjeti dio 4.8).
English: Tolucombi 40 mg/12.5 mg tablets EU/1/13/821/001
Croatian: Tolucombi 40 mg/12,5 mg tablete EU/1/13/821/001
English: Vascular disorders Uncommon: Hypotension, orthostatic hypotension
Croatian: Krvožilni poremećaji Manje često: hipotenzija, ortostatska hipotenzija
English: V. Holjevca 20/E 10450 Jastrebarsko Croatia
Croatian: KRKA - FARMA d.o.o. V. Holjevca 20/E 10450 Jastrebarsko Hrvatska
English: There is no clinical experience with Tolucombi in patients with hepatic impairment.
Croatian: Nema kliničkog iskustva s lijekom Tolucombi kod bolesnika s oštećenjem jetrene funkcije.
English: Warning signs of fluid or electrolyte imbalance are dryness of mouth, thirst, asthenia, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea or vomiting (see section 4.8).
Croatian: Znakovi koji upozoravaju na neravnotežu tekućine ili elektrolita su suhoća usta, žeđ, astenija, letargija, omamljenost, nemir, bolovi ili grčevi u mišićima, mišićni umor, hipotenzija, oligurija, tahikardija i gastrointestinalni poremećaji kao što su mučnina ili povraćanje (vidjeti dio 4.8).
English: Tolucombi 80 mg/12.5 mg tablets EU/1/13/821/011
Croatian: Tolucombi 80 mg/12,5 mg tablete EU/1/13/821/011
English: KRKA, d.d., Novo mesto Šmarješka cesta 6
Croatian: Novo mesto Šmarješka cesta 6
English: - Anti-cholinergic medicines (medicines used to treat a variety of disorders such as gastrointestinal cramps, urinary bladder spasm, asthma, motion sickness, muscular spasms, Parkinson's disease and as an aid to anaesthesia) such as atropine and biperiden.
Croatian: - Antikolinergički lijekovi (lijekovi koji se primjenjuju u liječenju niza poremećaja poput grčeva probavnog sustava, grča mokraćnog mjehura, astme, bolesti kretanja, grčeva mišića, Parkinsonove bolesti te kao pomoć u anesteziji) kao što su atropin i biperiden.
English: Lactose , sorbitol and sodium
Croatian: Laktoza, sorbitol i natrij
English: General disorders and administration site conditions Not known: Pyrexia
Croatian: Opći poremećaji i reakcije na mjestu primjene Nepoznato: pireksija
English: When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and
Croatian: Kada se trudnoća dijagnosticira, liječenje antagonistom receptora angiotenzina II mora se odmah prekinuti i, prema potrebi, započeti sa drugom terapijom (vidjeti dijelove 4.3 i 4.6).
English: - Medicines that are affected by changes of the blood potassium level such as heart medicines (e.g. digoxin) or medicines to control the rhythm of your heart (e.g. quinidine, disopyramide, amiodarone, sotalol), medicines used for mental disorders (e.g. thioridazine, chlorpromazine, levomepromazine) and other medicines such as certain antibiotics (e.g. sparfloxacine, pentamidine) or certain medicines to treat allergic reactions (e.g. terfenadine).
Croatian: - Lijekovi na koje utječu promjene vrijednosti kalija u krvi kao što su lijekovi za srce (npr. digoksin) ili lijekovi za kontrolu srčanog ritma (npr. kinidin, dizopiramid, amiodaron, sotalol), lijekovi koji se primjenjuju za duševne poremećaje (npr. tioridazin, klorpromazin, levomepromazin) i drugi lijekovi kao što su određeni antibiotici (npr. sparfloksacin, pentamidin) ili određeni lijekovi za liječenje alergijskih reakcija (npr. terfenadin).
English: Reproductive system and breast disorders Uncommon: Erectile dysfunction
Croatian: Poremećaji reproduktivnog sustava i dojki Manje često: erektilna disfunkcija
English: There was evidence for a benefit of telmisartan compared to placebo in the pre-specified secondary composite endpoint of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke [0.87 (95 % CI 0.76 - 1.00, p = 0.048)].
Croatian: Postojao je dokaz pozitivnih učinaka telmisartana u usporedbi s placebom u unaprijed određenom sekundarnom kompozitnom ishodu kardiovaskularne smrti, nefatalnog infarkta miokarda i nefatalnog moždanog udara [0,87 (95% CI 0,76 - 1,00, p = 0,048)].
English: - Severe renal impairment (creatinine clearance <30 ml/min).
Croatian: - Teško oštećenje bubrežne funkcije (klirens kreatinina <30 ml/min).
English: Blisters (OPA/Al/PE foil with desiccant//Al foil): 14 x 1 and 98 x 1 tablet in a box.
Croatian: Blisteri (OPA/Al/PE folija sa sredstvom za sušenje//Al folija): 14 x 1 i 98 x 1 tableta u kutiji.
English: Tolucombi is also available at the dose strengths 40 mg/12.5 mg and 80 mg/12.5 mg.
Croatian: Tolucombi je također dostupan u jačinama 40 mg/12,5 mg i 80 mg/12,5 mg.
English: Blood and lymphatic system disorders Uncommon: Anaemia Rare:
Croatian: Poremećaji krvi i limfnog sustava Manje često: anemija Rijetko:
English: Excipient(s) with known effect: Each tablet contains 114 mg of lactose (as monohydrate) and 294.08 mg sorbitol (E420).
Croatian: Pomoćna(e) tvar(i) s poznatim učinkom Jedna tableta sadrži 114 mg laktoze (u obliku hidrata) i 294,08 mg sorbitola (E420).
English: Nausea Not known: Pancreatitis, stomach discomfort
Croatian: mučnina Nepoznato: pankreatitis, nelagoda u želucu
English: In a double-blind controlled clinical trial (n=687 patients evaluated for efficacy) in non-responders to the 80 mg/12.5 mg combination, an incremental blood pressure lowering effect of the 80 mg/25 mg combination compared to continued treatment with the 80 mg/12.5 mg combination of 2.7/1.6 mmHg (SBP/DBP) was demonstrated (difference in adjusted mean changes from baseline).
Croatian: U dvostruko-slijepom kontroliranom kliničkom ispitivanju (djelotvornost ocjenjivana na n = 687 bolesnika) kod osoba koje nisu reagirale na kombinaciju 80 mg/12,5 mg, pokazao se inkrementalni učinak snižavanja krvnog tlaka kombinacije 80 mg/25 mg u odnosu na stalno liječenje s kombinacijom 80 mg/12,5 mg, u vrijednosti 2,7/1,6 mmHg (SKT/DKT) (razlika u prilagođenim prosječnim promjenama u odnosu na početnu vrijednost).
English: Vascular disorders Not known: Vasculitis necrotizing
Croatian: Krvožilni poremećaji Nepoznato: nekrotizirajući vaskulitis
English: Gastrointestinal disorders Uncommon: Diarrhoea, dry mouth, flatulence Rare:
Croatian: Poremećaji probavnog sustava Manje često: proljev, suha usta, flatulencija Rijetko:
English: Adverse reactions previously reported with one of the individual components may be potential adverse reactions with Tolucombi, even if not observed in clinical trials with this product.
Croatian: Dodatne informacije o individualnim komponentama Nuspojave prethodno prijavljene s jednom od individualnih komponenti mogu biti potencijalne nuspojave lijeka Tolucombi, čak iako nisu zabilježene u kliničkim ispitivanjima ovoga lijeka.
English: This medicine contains 294.08 mg sorbitol in each tablet, which is equivalent to 5 mg/kg/day, if the body weight is 58.8 kg.
Croatian: Ovaj lijek sadrži 294,08 mg sorbitola u jednoj tableti, što odgovara 5 mg/kg/dan, ako je tjelesna težina 58,8 kg.
English: In a pooled analysis of two similar 8 week double-blind placebo-controlled clinical trials vs. valsartan/hydrochlorothiazide 160 mg/25 mg (n=2121 patients evaluated for efficacy) a significantly greater blood pressure lowering effect of 2.2/1.2 mmHg (SBP/DBP) was demonstrated (difference in adjusted mean changes from baseline, respectively) in favour of telmisartan/hydrochlorothiazide 80 mg/25 mg combination.
Croatian: U združenoj analizi dvaju sličnih dvostruko-slijepih, placebom kontroliranih kliničkih ispitivanja, u trajanju 8 tjedana, u odnosu na valsartan/hidroklorotiazid 160 mg/25 mg (djelotvornost ocjenjivana na n = 2 121 bolesnika, pokazao se značajno veći učinak snižavanja krvnog tlaka, u vrijednosti 2,2/1,2 mmHg (SKT/DKT) (razlika u prilagođenim prosječnim promjenama u odnosu na početnu vrijednost, po istom redoslijedu) u korist kombinacije telmisartan/hidroklorotiazid 80 mg/25 mg.
English: Co-administration of thiazide may increase the incidence of hypersensitivity reactions of allopurinol.
Croatian: Istodobna primjena tiazida može povećati incidenciju reakcija preosjetljivosti na alopurinol.
English: Musculoskeletal, connective tissue and bone disorders Not known: Weakness
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva Nepoznato: slabost
English: Each 80 mg/12.5 mg tablet contains 114 mg of lactose (as monohydrate) and 294.08 mg sorbitol (E420).
Croatian: Jedna tableta 80 mg/12,5 mg sadrži 114 mg laktoze (u obliku hidrata) i 294,08 mg sorbitola (E420).
English: Some people feel dizzy or tired when taking Tolucombi.
Croatian: Neke osobe mogu osjećati omaglicu ili umor tijekom primjene lijeka Tolucombi.
English: Upper respiratory tract infection (e.g. sore throat, inflamed sinuses, common cold), urinary tract infections, deficiency in red blood cells (anaemia), high potassium levels, slow heart rate (bradycardia), kidney impairment including acute kidney failure, weakness, cough.
Croatian: Infekcija gornjeg dišnog sustava (npr. upaljeno grlo, upala sinusa, obična prehlada), infekcije mokraćnog sustava, nedostatak crvenih krvnih stanica (slabokrvnost/anemija), visoke vrijednosti kalija, usporena srčana frekvencija (bradikardija), oštećenje bubrega uključujući akutno zatajenje bubrega, slabost, kašalj.
English: Metabolism and nutrition disorders Uncommon: Hyperkalaemia Rare:
Croatian: Poremećaji metabolizma i prehrane Manje često: hiperkalemija Rijetko:
English: Telmisartan was found to be similarly effective to ramipril in the pre-specified secondary endpoint of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke [0.99 (97.5 % CI 0.901.08), p (non-inferiority) = 0.0004], the primary endpoint in the reference study HOPE (The Heart Outcomes Prevention Evaluation Study), which had investigated the effect of ramipril vs. placebo.
Croatian: Otkriveno je da telmisartan ima sličnu učinkovitost kao i ramipril u unaprijed određenom sekundarnom ishodu od kardiovaskularne smrti, nefatalnog infarkta miokarda i nefatalnog moždanog udara [0,99 (97,5% CI 0,90 - 1,08), p (za neinferiornost) = 0,0004], što je bio primarni ishod u referentnoj studiji HOPE (studija procjene prevencije ishoda povezanih sa srcem - engl.
English: Cardiac disorders Uncommon: Tachycardia, arrhythmias
Croatian: Srčani poremećaji Manje često: tahikardija, aritmije
English: How to store Tolucombi
Croatian: Kako čuvati Tolucombi
English: Muscoloskeletal, connective tissue and bone disorders Uncommon: Back pain, muscle spasms, myalgia Rare:
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva Manje često: bol u leđima, spazmi mišića, mialgija Rijetko:
English: Inflammation of the lung (bronchitis), activation or worsening of systemic lupus erythematosus (a disease where the body's immune system attacks the body, which causes joint pain, skin rashes and fever); sore throat, inflamed sinuses; feeling sad (depression), difficulty falling asleep (insomnia), impaired vision, difficulty breathing, abdominal pain, constipation, bloating (dyspepsia), feeling sick (vomiting), inflammation of the stomach (gastritis), abnormal liver function (Japanese patients are more likely to experience this side effect), redness of the skin (erythema), allergic reactions such as itching or rash, increased sweating, hives (urticaria), joint pain (arthralgia) and pain in extremities, muscle cramps, flu-like-illness, pain, low levels of sodium, increased levels of creatinine, hepatic enzymes or creatine phosphokinase in the blood.
Croatian: Upala pluća (bronhitis), aktivacija ili pogoršanje sistemskog lupus eritematozusa (bolest u kojoj imunološki sustav tijela napada tijelo, što izaziva bolove u zglobovima, osipe po koži i vrućicu), upaljeno grlo, upala sinusa, osjećaj tuge (depresija), problemi s usnivanjem (nesanica), oštećenje vida, otežano disanje, bol u trbuhu, zatvor, nadutost (probavne tegobe), osjećaj mučnine (povraćanje), upala želuca (gastritis), abnormalna jetrena funkcija (japanska populacija ima veće izglede za ovu nuspojavu), crvenilo kože (eritem), alergijske reakcije kao što su svrbež ili osip, pojačano znojenje, koprivnjača (urtikarija), bol zglobova (artralgija) i bol u udovima, grčevi u mišićima, bolest nalik gripi, bolovi, niske vrijednosti natrija, povišene vrijednosti kreatinina, jetrenih enzima ili kreatin fosfokinaze u krvi.
English: - Hyponatraemia and hypochloraemic alkalosis There is no evidence that Tolucombi would reduce or prevent diuretic-induced hyponatraemia.
Croatian: Ne postoje dokazi da Tolucombi smanjuje ili sprječava hiponatremiju induciranu diureticima.