FrancophonIA/ELRC3.0 huggingface dataset:
English: Specific interaction studies with other medicinal products have not been performed with AZOPT.
Slovenian: Specifičnih študij medsebojnega delovanja zdravila AZOPT z drugimi zdravili še niso opravili.
English: If you are using other eye drops, leave at least 5 minutes between putting in AZOPT and the other drops.
Slovenian: Če uporabljate tudi druge kapljice za oko, počakajte najmanj 5 minut med uporabo zdravila AZOPT in drugih kapljic.
English: AZOPT has not been studied in patients with severe renal impairment (creatinine clearance < 30 ml/min) or in patients with hyperchloraemic acidosis.
Slovenian: Zdravila AZOPT še niso preskušali pri bolnikih s hudo ledvično okvaro (očistek kreatinina <30 ml/min) ali pri tistih s hiperkloremično acidozo.
English: Write down the date you opened each bottle in the space below and in the space on the bottle label and box.
Slovenian: Zapišite datum odprtja vsebnika spodaj in na vsako nalepko vsebnika ter na škatlo.
English: The concomitant administration of AZOPT and oral carbonic anhydrase inhibitors has not been studied and is not recommended (see also section 4.5).
Slovenian: Sočasne uporabe zdravila AZOPT in peroralnih zaviralcev karboanhidraze še niso raziskovali in je ne priporočamo (glejte tudi poglavje 4.5).
English: If you have further questions, ask your doctor for advice.
Slovenian: Če imate dodatna vprašanja, se posvetujte se s svojim zdravnikom.
English: In plasma, both brinzolamide and Ndesethylbrinzolamide concentrations are low and generally below assay quantitation limits (<7.5 ng/ml).
Slovenian: V plazmi sta tako koncentraciji brinzolamida kot N-desetilbrinzolamida nizki in običajno pod mejo kvantifikacije (<7,5 ng/ml).
English: The safety and efficacy of AZOPT in infants, children and adolescents aged 0 to 17 years have not been established.
Slovenian: Varnost in učinkovitost zdravila AZOPT pri dojenčkih, otrocih in mladostnikih, starih 0 do 17 let, še nista bili dokazani.
English: Since brinzolamide and its main metabolite are excreted predominantly by the kidney, AZOPT is therefore contra-indicated in such patients (see also section 4.3).
Slovenian: Ker se brinzolamid in njegov glavni presnovek izločata predvsem skozi ledvice, je zdravilo AZOPT pri teh bolnikih kontraindicirano (glejte tudi poglavje 4.3).
English: The inhibition of total RBC CA activity at steady state was approximately 70-75%.
Slovenian: Inhibicija celotne aktivnosti eritrocitne CA v stanju dinamičnega ravnovesja je bila približno od 70 do 75 %.
English: Subjects with moderate renal impairment (creatinine clearance of 30-60 ml/minute) were administered 1 mg of brinzolamide twice daily orally for up to 54 weeks.
Slovenian: Preiskovanci z zmerno ledvično okvaro (očistek kreatinina od 30 do 60 ml/minuto) so prejemali 1 mg brinzolamida dvakrat na dan peroralno do 54 tednov.
English: Specifically, patients wearing contact lenses have not been studied and careful monitoring of these patients when using brinzolamide is recommended, since carbonic anhydrase inhibitors may affect corneal hydration and wearing contact lenses might increase the risk for the cornea.
Slovenian: Natančneje, v raziskavah niso obravnavali bolnikov, ki nosijo kontaktne leče, in priporočamo skrbno spremljanje teh bolnikov pri uporabi brinzolamida, saj lahko zaviralci karboanhidraze vplivajo na hidracijo roženice in lahko pri njih nošenje kontaktnih leč poveča tveganje za okvaro roženice.
English: If you stop using AZOPT
Slovenian: Če ste prenehali uporabljati zdravilo AZOPT
English: A clinical trial was conducted with AZOPT in 32 paediatric patients less than 6 years of age, diagnosed with glaucoma or ocular hypertension.
Slovenian: Opravljeno je bilo klinično preskušanje z zdravilom AZOPT pri 32 pediatričnih bolnikih, mlajših od 6 let, ki so imeli diagnozo glavkoma ali očesne hipertenzije.
English: B-2870 Puurs, Belgium.
Slovenian: B-2870 Puurs Belgija ali
English: If affected, take care when driving or using machines.
Slovenian: Če zdravilo vpliva na vas, morate biti previdni pri vožnji ali upravljanju s stroji.
English: In small short-term clinical trials, approximately 12.5% of paediatric patients were observed to experience adverse reactions, the majority of which were local, non-serious ocular reactions such as conjunctival hyperaemia, eye irritation, eye discharge, and lacrimation increased (see also section 5.1).
Slovenian: V majhnih, kratkotrajnih kliničnih preskušanjih so opazili, da je imelo približno 12,5 % pediatričnih bolnikov neželene učinke, ki so bili večinoma lokalne reakcije na očeh, ki niso opredeljene kot resne, na primer hiperemija veznice, draženje očesa, izcedek iz očesa in povečano solzenje (glejte tudi poglavje 5.1).
English: 5 and 10 ml opaque low density polyethylene bottles with polypropylene screw caps (droptainer).
Slovenian: 5 in 10 ml neprozorni kapalni vsebniki iz polietilena nizke gostote s polipropilensko navojno zaporko (droptainer).
English: No long term data are available on the use of AZOPT as adjunctive therapy to travoprost(see also section 5.1).
Slovenian: Ni dolgoročnih podatkov o uporabi zdravila AZOPT za dodatno zdravljenje ob travoprostu (glejte tudi poglavje 5.1).
English: Nasolacrimal occlusion or gently closing the eyelid after instillation may help reduce the incidence of this effect (see also section 4.2).
Slovenian: Zaprtje nazolakrimalnega kanala ali nežno priprtje vek po vkapanju lahko pomaga zmanjšati pogostnost tega učinka (glejte tudi poglavje 4.2).
English: AZOPT contains benzalkonium chloride
Slovenian: Zdravilo AZOPT vsebuje benzalkonijev klorid
English: Studies in animals have shown reproductive toxicity following systemic administration (see also section 5.3).
Slovenian: Študije na živalih so pokazale vpliv na sposobnost razmnoževanja po sistemski uporabi (glejte poglavje 5.3).
English: Brinzolamide saturation of RBC CA-II was achieved within 4 weeks (RBC concentrations of approximately 20 µM).
Slovenian: Nasičenost eritrocitne CA-II z brinzolamidom so dosegli v 4 tednih (eritrocitna koncentracija približno 20 µM).
English: The safety and efficacy of AZOPT in infants, children and adolescents aged 0 to 17 years have not been established and its use is not recommended in infants, children or adolescents
Slovenian: Varnost in učinkovitost zdravila AZOPT pri dojenčkih, otrocih in mladostnikih, starih 0 do 17 let, še nista bili dokazani in njegova uporaba pri dojenčkih, otrocih in mladostnikih ni priporočljiva.
English: Electrolyte imbalance, development of an acidotic state, and possible nervous system effects may occur.
Slovenian: Lahko se pojavijo motnje ravnovesja elektrolitov, nastanek acidoze in možni neželeni učinki na živčevje.
English: Caution should be used in treating these patients and close monitoring of intraocular pressure (IOP) is recommended.
Slovenian: Pri zdravljenju teh bolnikov je potrebna previdnost in priporočljivo je skrbno spremljanje očesnega tlaka.
English: It is likely caused by passage of the eye drops in the nasopharynx via the nasolacrimal canal.
Slovenian: Verjetno ga povzroči prehajanje kapljic za oko v nosni del žrela po nazolakrimalnem kanalu.
English: There was an overall higher incidence of non-serious ocular adverse reactions, mainly related to signs of local irritation, in the brinzolamide/travoprost groups.
Slovenian: Skupna incidenca očesnih neželenih učinkov, ki niso bili resni, je bila večja, predvsem zaradi znakov lokalnega draženja v skupinah, ki sta prejemali brinzolamid oziroma travoprost.
English: This metabolite binds mainly to CA-I in the presence of brinzolamide.
Slovenian: Ta presnovek se veže predvsem na CA-I v prisotnosti brinzolamida.
English: Women who may become pregnant are advised to use effective contraception during AZOPT treatment.
Slovenian: Ženskam v rodni dobi svetujemo, da med zdravljenjem z zdravilom AZOPT uporabljajo učinkovito kontracepcijo.
English: If you forget to use AZOPT
Slovenian: Če ste pozabili uporabiti zdravilo AZOPT
English: What AZOPT is and what it is used for What you need to know before you use AZOPT How to use AZOPT
Slovenian: Kaj je zdravilo AZOPT in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo AZOPT Kako uporabljati zdravilo AZOPT Možni neželeni učinki
English: White to off-white suspension.
Slovenian: AZOPT je bela do sivo bela suspenzija.
English: Animal studies have shown the excretion of minimal levels of brinzolamide in breast milk following oral administration.
Slovenian: Študije na živalih kažejo na izločanje minimalnih količin brinzolamida v mleko samic po peroralni uporabi.
English: Instruct patients to keep the bottle tightly closed when not in use.
Slovenian: Bolnika poučite, da mora biti kapalni vsebnik tesno zaprt, ko ni v uporabi.
English: The cytochrome P-450 isozymes responsible for metabolism of brinzolamide include CYP3A4 (main), CYP2A6, CYP2C8 and CYP2C9.
Slovenian: Izoencimi citokroma P-450, ki so odgovorni za presnovo brinzolamida, so CYP3A4 (glavni), CYP2A6, CYP2C8 in CYP2C9.
English: Patients must be instructed to remove contact lenses prior to the application of AZOPT and wait at least 15 minutes after instillation of the dose before reinsertion.
Slovenian: Bolnikom svetujte, naj kontaktne leče odstranijo pred vkapanjem zdravila AZOPT in naj po vkapanju počakajo najmanj 15 minut, preden si jih spet vstavijo.
English: • ocular hypertension
Slovenian: • očesni hipertenziji
English: Not Known: hypersensitivity
Slovenian: Neznana: preobčutljivost
English: At steady-state, brinzolamide and its metabolite RBC concentrations ranged from 22.0 to 46.1 and 17.1 to 88.6 µM, respectively.
Slovenian: V stanju dinamičnega ravnovesja se je koncentracija brinzolamida in njegovega presnovka v eritrocitih gibala med 22,0 in 46,1 za brinzolamid ter med 17,1 in 88,6 M za presnovek.
English: The use of AZOPT is not recommended during pregnancy or breast-feeding.
Slovenian: Uporaba zdravila AZOPT med nosečnostjo ali dojenjem ni priporočljiva.
English: Developmental toxicity studies in rabbits with oral doses of brinzolamide of up to 6 mg/kg/day (125 times the recommended human ophthalmic dose) revealed no effect on foetal development despite significant maternal toxicity.
Slovenian: Študije razvojne toksičnosti pri kuncih s peroralnimi odmerki brinzolamida do 6 mg/kg na dan (125-kratni priporočeni očesni odmerek za človeka) niso pokazale nobenega vpliva zdravila na razvoj ploda kljub znatni toksičnosti zdravila za mater.
English: Common: dysgeusia
Slovenian: Pogosti: disgevzija
English: Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humour secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
Slovenian: Inhibicija karboanhidraze v ciliarnih grebenih v očesu zmanjša izločanje prekatne vodke, verjetno tako, da upočasni tvorbo bikarbonatnih ionov, s posledičnim zmanjšanjem transporta natrija in tekočine.
English: AZOPT is absorbed systemically and therefore this may occur with topical administration.
Slovenian: Zdravilo AZOPT se absorbira sistemsko, zato se to lahko zgodi tudi pri topikalni uporabi zdravila.
English: AZOPT contains brinzolamide which belongs to a group of medicines called carbonic anhydrase inhibitors.
Slovenian: AZOPT vsebuje brinzolamid, ki sodi v skupino zdravil, imenovanih zaviralci encima karboanhidraze.
English: • open-angle glaucoma as monotherapy in adult patients unresponsive to beta-blockers or in adult patients in whom betablockers are contraindicated, or as adjunctive therapy to beta-blockers or prostaglandin analogues (see also section 5.1).
Slovenian: • glavkomu odprtega zakotja, bodisi za monoterapijo pri odraslih bolnikih, ki se ne odzivajo na zaviralce beta receptorjev ali so pri njih zaviralci beta receptorjev kontraindicirani, ali pa kot dodatno zdravljenje poleg zaviralcev beta receptorjev ali prostaglandinskih analogov (glejte tudi poglavje 5.1).
English: In clinical studies involving 2732 patients treated with AZOPT as monotherapy or adjunctive therapy to timolol maleate 5 mg/ml, the most frequently reported treatment-related adverse reactions were: dysgeusia (6.0%) (bitter or unusual taste, see description below) and temporary blurred vision (5.4%) upon instillation, lasting from a few seconds to a few minutes (see also section 4.7).
Slovenian: V kliničnih študijah pri 2732 bolnikih, zdravljenih z zdravilom AZOPT v obliki monoterapije ali dodatnega zdravljenja s timololijevim maleatom 5 mg/ml, so bili, z zdravljenjem povezani, najpogostejši neželeni učinki naslednji: disgevzija (6,0 %) (grenak ali nenavaden okus, glejte opis spodaj) in začasno zamegljen vid (5,4 %) po vkapanju zdravila, ki je trajal od nekaj sekund do nekaj minut (glejte tudi poglavje 4.7).
English: When used as monotherapy or adjunctive therapy, the dose is one drop of AZOPT in the conjunctival sac of the affected eye(s) twice daily.
Slovenian: Pri uporabi zdravila AZOPT v monoterapiji ali za dodatno zdravljenje je odmerek zdravila AZOPT ena kapljica v veznično vrečko prizadetega očesa oziroma oči dvakrat na dan.
English: It reduces pressure within the eye.
Slovenian: Deluje tako, da zniža očesni tlak.
English: Brinzolamide, an inhibitor of carbonic anhydrase II (CA-II), the predominant iso-enzyme in the eye, with an in vitro IC50 of 3.2 nM and a Ki of 0.13 nM against CA-II.
Slovenian: Brinzolamid je zaviralec karboanhidraze II (CA-II), prevladujočega očesnega izoencima, in ima vrednosti in vitro IC50 3,2 nM in Ki 0,13 nM za CA-II.
English: Opened (1): Opened (2): Opened (3):
Slovenian: Odprto (1): Odprto (2): Odprto (3):
English: For ocular use.
Slovenian: za okularno uporabo
English: Pharmacotherapeutic group: Antiglaucoma preparations and miotics, carbonic anhydrase inhibitors, ATC code: S01EC04
Slovenian: Farmakoterapevtska skupina: Zdravila za zdravljenje glavkoma in zdravila za zožitev zenice, zaviralci karboanhidraze, oznaka ATC: S01EC04
English: Due to its high affinity for CA-II, brinzolamide distributes extensively into the red blood cells (RBCs) and exhibits a long half-life in whole blood (mean of approximately 24 weeks).
Slovenian: Zaradi velike afinitete za CA-II se v veliki meri porazdeli v eritrocitih in ima v polni krvi dolgo razpolovno dobo (srednja vrednost približno 24 tednov).
English: Do not use this medicine after the expiry date which is stated on the bottle and box after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na kapalnem vsebniku in na škatli poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: The following pack sizes are available: outer cartons containing 1 x 5 ml, 3 x 5 ml and 1 x 10 ml bottles.
Slovenian: Na voljo so naslednje velikosti pakiranj: škatle z 1 x 5 ml, 3 x 5 ml in 1 x 10 ml kapalnimi vsebniki.
English: Since AZOPT contains benzalkonium chloride, close monitoring is required with frequent or prolonged use in dry eye patients, or in conditions where the cornea is compromised.
Slovenian: Ker AZOPT vsebuje benzalkonijev klorid, je potrebno pri pogosti ali daljši uporabi tega zdravila skrbno spremljati bolnike s sindromom suhega očesa ali tiste s prizadeto roženico.
English: About 20% of the dose has been accounted for in urine as metabolite.
Slovenian: Približno 20 % odmerka se izloči s sečem v obliki presnovkov.
English: • Hold the bottle, pointing down, between your thumb and middle finger
Slovenian: • Kapalni vsebnik držite s palcem in sredincem, obrnjenega navzdol.
English: N-Desethylbrinzolamide accumulated in RBCs to steady state within 2028 weeks reaching concentrations ranging from 6-30 µM.
Slovenian: N-desetilbrinzolamid se je nakopičil v eritrocitih in dosegel v njih stanje dinamičnega ravnovesja v 20 do 28 tednih, pri koncentraciji od 6 do 30 µM.
English: - if you are taking other sulphonamide medicines - if you have a specific form of glaucoma in which the pressure inside the eye rises due to deposits that block fluid draining out (pseudoexfoliative glaucoma or pigmentary glaucoma) or a specific form of glaucoma in which the pressure inside the eye (sometimes rapidly) rises because the eye bulges forward and blocks fluid draining out (narrow-angle glaucoma)
Slovenian: - če imate posebno obliko glavkoma, pri kateri se tlak v notranjosti očesa zviša zaradi depozitov (skupkov), ki preprečujejo odtekanje tekočine (psevdoeksfoliacijski glavkom ali pigmentni glavkom), ali posebno obliko glavkoma, pri kateri se tlak v notranjosti očesa (včasih zelo hitro) zviša zato, ker se oko izboči naprej in to preprečuje odtekanje tekočine (glavkom ozkega zakotja).
English: • Do not touch your eye or eyelid, surrounding areas or other surfaces with the dropper.
Slovenian: • Ne dotikajte se očesa, veke, kože v bližini ali drugih površin s kapalko, saj lahko pride do okužbe kapljic.
English: Rare: memory impairment, somnolence Not Known: tremor, hypoaesthesia, ageusia
Slovenian: Redki: motnje spomina, somnolenca Neznana: tremor, hipestezija, agevzija
English: AZOPT contains a preservative (benzalkonium chloride) which may be absorbed by soft contact lenses and may change the colour of the contact lenses.
Slovenian: Zdravilo AZOPT vsebuje konzervans (benzalkonijev klorid), ki se lahko absorbira v mehke kontaktne leče in lahko spremeni barvo kontaktnih leč.
English: How to use AZOPT
Slovenian: Kako uporabljati zdravilo AZOPT
English: It is unknown whether brinzolamide/metabolites are excreted in human milk following topical ocular administration.
Slovenian: Ni znano, ali se brinzolamid/presnovki izločajo v materino mleko po topikalni okularni uporabi.
English: AZOPT is not recommended during pregnancy and in women of childbearing potential not using contraception.
Slovenian: Zdravila AZOPT ne uporabljajte med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo učinkovite kontracepcije.
English: • Gently press on the base of the bottle to release one drop of AZOPT at a time.
Slovenian: • Z rahlim pritiskom na dno kapalnega vsebnika vsakokrat iztisnite po eno kapljico zdravila
English: Benzalkonium chloride, which is commonly used as a preservative in ophthalmic products, has been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy.
Slovenian: Poročali so, da benzalkonijev klorid, ki se pogosto uporablja kot konzervans v očesnih zdravilih, povzroča točkasto keratopatijo ali toksično ulcerozno keratopatijo ali oboje.
English: • Do not squeeze the bottle: it is designed so that a gentle press on the bottom is all that it needs
Slovenian: • Ne stiskajte kapalnega vsebnika: narejen je tako, da je vsakokrat potreben le rahel pritisk na njegovo dno (slika 2).
English: AZOPT 10 mg/ml eye drops, suspension
Slovenian: AZOPT 10 mg/ml kapljice za oko, suspenzija
English: Tiny amounts of hydrochloric acid or sodium hydroxide are added to keep acidity levels (pH levels) normal.
Slovenian: Zdravilu včasih dodamo majhne količine klorovodikove kisline ali natrijevega hidroksida, da zagotovimo normalno kislost (vrednost pH).
English: In clinical studies, AZOPT was used concomitantly with prostaglandin analogues and timolol ophthalmic preparations without evidence of adverse interactions.
Slovenian: V kliničnih študijah so zdravilo AZOPT uporabljali sočasno s prostaglandinskimi analogi in očesnimi zdravili, ki vsebujejo timolol, pri tem pa niso ugotovili znakov neželenega medsebojnega delovanja.
English: Careful monitoring of patients with compromised corneas such as patients with diabetes mellitus or corneal dystrophies is recommended.
Slovenian: Priporočamo skrbno spremljanje bolnikov z okvaro roženice, npr. tistih s sladkorno boleznijo ali distrofijo roženice.
English: N-desethylbrinzolamide RBC concentrations increased and total RBC CA activity decreased with decreasing creatinine clearance but brinzolamide RBC concentrations and CA-II activity remained unchanged.
Slovenian: Z zmanjšanjem očistka kreatinina se je koncentracija N-desetilbrinzolamida v eritrocitih povečala in celotna aktivnost CA v eritrocitih zmanjšala, toda eritrocitna koncentracija brinzolamida in aktivnost CA-II sta ostali nespremenjeni.
English: The following side effects have been seen with AZOPT.
Slovenian: Naslednje neželene učinke so opazili pri zdravilu AZOPT.
English: Use with caution in patients with risk of renal impairment because the possible risk of metabolic acidosis (see section 4.2).
Slovenian: Zaradi možnega tveganja za metabolično acidozo je treba to zdravilo uporabljati previdno pri bolnikih s tveganjem za ledvično okvaro (glejte poglavje 4.2).
English: Description of selected adverse events
Slovenian: Opis izbranih neželenih učinkov
English: In humans, the metabolite N-desethylbrinzolamide is formed, which also binds to CA and accumulates in RBCs.
Slovenian: Pri človeku nastaja presnovek N-desetil-brinzolamid, ki se tudi veže na CA in se kopiči v eritrocitih.
English: AZOPT is not recommended for use in infants, children and adolescents.
Slovenian: Uporaba zdravila AZOPT pri dojenčkih, otrocih in mladostnikih ni priporočljiva.
English: AZOPT may impair the ability to perform tasks requiring mental alertness and/or physical coordination.
Slovenian: Zdravilo AZOPT lahko zmanjša sposobnost za opravljanje nalog, ki zahtevajo miselno zbranost ali telesno koordinacijo ali oboje.
English: Uncommon: foreign body in eye
Slovenian: Občasni: tujek v očesu
English: To prevent contamination of the dropper tip and suspension, care must be taken not to touch the eyelids, surrounding areas or other surfaces with the dropper tip of the bottle.
Slovenian: Kontaminacijo vrha kapalnega vsebnika in suspenzije preprečimo tako, da pazimo, da se z vrhom kapalnega vsebnika ne dotaknemo vek, kože v bližini ali drugih površin.
English: Uncommon: apathy, depression, depressed mood, libido decreased, nightmare, nervousness Rare: insomnia
Slovenian: Občasni: apatija, depresija, depresivno razpoloženje, zmanjšana spolna sla, nočne more, živčnost Redki: nespečnost
English: If you are taking another carbonic anhydrase inhibitor (acetazolamide or dorzolamide, see section 1 What AZOPT is and what it is used for), talk to your doctor.
Slovenian: Če jemljete tudi kakšen drug zaviralec encima karboanhidraze (acetazolamid ali dorzolamid, glejte poglavje 1.
English: If more than one topical ophthalmic medicinal product is being used, the medicines must be administered at least 5 minutes apart.
Slovenian: Če bolnik sočasno uporablja več topikalnih očesnih zdravil, jih mora uporabljati z razmikom najmanj 5 minut.
English: Only use AZOPT in both eyes if your doctor told you to. Take it for as long as your doctor told you to.
Slovenian: Zdravilo AZOPT uporabljajte na obeh očeh le, če vam je zdravnik to svetoval.
English: There is limited experience with AZOPT in the treatment of patients with pseudoexfoliative glaucoma or pigmentary glaucoma.
Slovenian: Izkušnje z uporabo zdravila AZOPT pri zdravljenju bolnikov s psevdoeksfoliacijskim glavkomom ali pigmentnim glavkomom so omejene.
English: Among patients who were naive to IOP therapy (10 patients), the efficacy of AZOPT was similar to that seen previously in adults, with mean IOP reductions from baseline ranging up to 5 mmHg.
Slovenian: Pri bolnikih, ki pa še niso nikoli jemali zdravil za znižanje očesnega tlaka (10 bolnikov), je bila učinkovitost zdravila AZOPT podobna, kot so jo pred tem opažali pri odraslih s srednjim znižanjem očesnega tlaka za največ 5 mmHg glede na začetno vrednost.
English: AZOPT 10 mg/ml eye drops, suspension brinzolamide
Slovenian: AZOPT 10 mg/ml kapljice za oko, suspenzija brinzolamid
English: Oral carbonic anhydrase inhibitors may impair the ability to perform tasks requiring mental alertness and/or physical coordination (see also section 4.4 and section 4.8).
Slovenian: Peroralni zaviralci karboanhidraze lahko zmanjšajo sposobnost za opravljanje del, pri katerih je potrebna miselna zbranost ali dobra telesna koordinacija ali oboje (glejte tudi poglavje 4.4 in poglavje 4.8).
English: Uncommon: renal pain Not Known: pollakiuria
Slovenian: Občasni: ledvične bolečine Neznana: polakisurija
English: 4.7 Effects on ability to drive and use machines
Slovenian: 4.7 Vplivi na sposobnost vožnje in upravljanja strojev Zdravilo AZOPT ima blag vpliv na sposobnost vožnje in upravljanja strojev.