FrancophonIA/ELRC3.0 huggingface dataset:
English: Concomitant use of boosted darunavir and elbasvir/grazoprevir is contraindicated (see section 4.3).
Croatian: darunavira s elbasvirom/grazoprevirom je kontraindicirana (vidjeti dio 4.3).
English: The use of carbamazepine with darunavir co-administered with cobicistat is contraindicated (see section 4.3).
Croatian: Primjena karbamazepina s darunavirom istodobno primijenjenog s kobicistatom je kontraindicirana (vidjeti dio 4.3).
English: Clotrimazole
Croatian: Klotrimazol
English: ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17%
Croatian: ANTIBIOTICI Klaritromicin 500 mg dvaput na dan klaritromicin AUC ↑ 57% klaritromicin Cmin ↑ 174% klaritromicin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17% Koncentraciju 14-OHklaritromicina nije bilo moguće odrediti kada se kombinirao s darunavirom/ritonavirom. (↑klaritromicina zbog inhibicije CYP3A i moguće P-gp inhibicije)
English: silica, colloidal anhydrous ) and magnesium stearate (E470b)in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) and red iron oxide (E172) in film coating.
Croatian: - Drugi sastojci su mikrokristalična celuloza, krospovidon, hidroksipropilceluloza, koloidni bezvodni silicijev dioksid, silicificirana mikrokristalična celuloza (mikrokristalična celuloza, koloidni bezvodni silicijev dioksid) i magnezijev stearat (E470b) u jezgri tablete te poli(vinilni alkohol), makrogol, titanijev dioksid (E171), talk (E553b), žuti željezov oksid (E172) i crveni željezov oksid (E172) u film ovojnici tablete.
English: Lovastatin and simvastatin are expected to have markedly increased plasma concentrations when coadministered with boosted darunavir.
Croatian: Za lovastatin i simvastatin se očekuje značajno povišenje koncentracija u plazmi kada se primjenjuju istodobno s pojačanim darunavirom. (inhibicija CYP3A)
English: Darunavir co-administered with low dose ritonavir can be used with these NRTIs without dose adjustment.
Croatian: Darunavir istodobno primijenjen s niskom dozom ritonavira može se primijeniti s ovim NRTI lijekovima bez prilagodbe doze.
English: Darunavir co-administered with cobicistat lowers the creatinine clearance.
Croatian: Darunavir istodobno primijenjen s kobicistatom snižava klirens kreatinina.
English: The pharmacokinetics of darunavir in combination with ritonavir taken once daily in 12 ART-naïve paediatric patients, aged 12 to < 18 years and weighing at least 40 kg, showed that darunavir/ritonavir 800/100 mg once daily results in darunavir exposure that was comparable to that achieved in adults receiving darunavir/ritonavir 800/100 mg once daily.
Croatian: Farmakokinetika darunavira u kombinaciji s ritonavirom uzetih jedanput na dan, u 12 pedijatrijskih bolesnika koji nisu prethodno liječeni, u dobi od 12 do < 18 godina s težinom najmanje 40 kg, pokazala je da darunavir/ritonavir 800/100 mg jedanput na dan rezultira izloženošću darunaviru koja je usporediva s onom u odraslih koji primaju darunavir/ritonavir od 800/100 mg jedanput na dan.
English: Each film-coated tablet contains 600 mg darunavir.
Croatian: Jedna filmom obložena tableta sadrži 600 mg darunavira.
English: Darunavir Krka 800 mg film-coated tablets:
Croatian: Darunavir Krka 800 mg filmom obložene tablete:
English: Hence, concomitant use of boosted darunavir and the combination product lopinavir/ritonavir is contraindicated (see section 4.3).
Croatian: Odavde proizlazi da je istodobna primjena pojačanog darunavira i kombiniranog lijeka lopinavir/ritonavir kontraindicirana (vidjeti dio 4.3).
English: These active substances include e.g.: alfuzosin amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine astemizole, terfenadine colchicine when used in patients with renal and/or hepatic impairment (see section 4.5) ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine) elbasvir/grazoprevir cisapride dapoxetine domperidone naloxegol lurasidone, pimozide, quetiapine, sertindole (see section 4.5) triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5) sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5).
Croatian: (vidjeti dio 4.5) - ergot derivate (npr. dihidroergotamin, ergometrin, ergotamin, metilergonovin) - elbasvir/grazoprevir - cisaprid - dapoksetin - domperidon - naloksegol - lurasidon, pimozid, kvetiapin, sertindol (vidjeti dio 4.5) - triazolam, peroralno primijenjen midazolam (mjere opreza za parenteralnu primjenu midazolama, vidjeti dio 4.5) - sildenafil -kada se primjenjuje za liječenje plućne arterijske hipertenzije,
English: Do not combine Darunavir Krka with any of the following medicines If you are taking any of these, ask your doctor about switching to another medicine.
Croatian: Nemojte kombinirati Darunavir Krka ni s jednim od sljedećih lijekova
English: Number of baseline mutations
Croatian: Broj mutacija na početu liječenja
English: Patients co-infected with hepatitis B and/or hepatitis C virus Among 1,968 treatment-experienced patients receiving darunavir co-administered with ritonavir 600/100 mg twice daily, 236 patients were co-infected with hepatitis B or C. Co-infected patients were more likely to have baseline and treatment emergent hepatic transaminase elevations than those without chronic viral hepatitis (see section 4.4).
Croatian: Bolesnici istodobno inficirani virusom hepatitisa B i/ili hepatitisa C Od 1968 prethodno liječenih bolesnika, a primali su darunavir primijenjen istodobno s ritonavirom od 600/100 mg dvaput na dan, 236 bolesnika bilo je istodobno inficirano hepatitisom B ili C.
English: Other medicines and Darunavir Krka Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: 30 film-coated tablets: EU/1/17/1249/001 60 film-coated tablets: EU/1/17/1249/002 90 film-coated tablets: EU/1/17/1249/003 180 film-coated tablets: EU/1/17/1249/004
Croatian: 30 filmom obloženih tableta: EU/1/17/1249/001 60 filmom obloženih tableta: EU/1/17/1249/002 90 filmom obloženih tableta: EU/1/17/1249/003 180 filmom obloženih tableta: EU/1/17/1249/004
English: 375 mg darunavir /50 mg ritonavir twice daily
Croatian: 375 mg darunavir /50 mg ritonavir dvaput na dan
English: 600 mg darunavir/100 mg ritonavir once daily
Croatian: 600 mg darunavir/100 mg ritonavir jedanput na dan
English: Imputations according to the TLOVR algorithm.
Croatian: Pripisane vrijednosti izračunate prema TLOVR algoritmu
English: 800 mg darunavir /100 mg ritonavir once daily
Croatian: 800 mg darunavir /100 mg ritonavir jedanput na dan
English: These active substances include e.g.: alfuzosin amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine astemizole, terfenadine colchicine when used in patients with renal and/or hepatic impairment (see section 4.5) ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine) elbasvir/grazoprevir cisapride dapoxetine domperidone naloxegol lurasidone, pimozide, quetiapine, sertindole (see section 4.5) triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5) sildenafil -when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5).
Croatian: (vidjeti dio 4.5) - ergot derivate (npr. dihidroergotamin, ergometrin, ergotamin, metilergonovin) - elbasvir/grazoprevir - cisaprid - dapoksetin - domperidon - naloksegol - lurasidon, pimozid, kvetiapin, sertindol (vidjeti dio 4.5) - triazolam, peroralno primijenjen midazolam (mjere opreza za parenteralnu primjenu midazolama, vidjeti dio 4.5)
English: Boosted darunavir with triazolam or oral midazolam is contraindicated (see section 4.3)
Croatian: Pojačan darunavir s triazolamom ili peroralnim midazolamom je kontraindiciran (vidjeti dio 4.3).
English: Co-administration of boosted darunavir with clonazepam may increase concentrations of clonazepam.
Croatian: Istodobna primjena pojačanog darunavira s klonazepamom može povećati koncentracije klonazepama. (CYP3A inhibicija)
English: United Kingdom Consilient Health (UK) Ltd. Tel: +44 (0)203 751 1888
Croatian: Tel: +44 (0)203 751 1888
English: 30 film-coated tablets: EU/1/17/1249/005 60 film-coated tablets: EU/1/17/1249/006 90 film-coated tablets: EU/1/17/1249/007 180 film-coated tablets: EU/1/17/1249/008
Croatian: 30 filmom obloženih tableta: EU/1/17/1249/005 60 filmom obloženih tableta: EU/1/17/1249/006 90 filmom obloženih tableta: EU/1/17/1249/007 180 filmom obloženih tableta: EU/1/17/1249/008
English: darunavir AUC24h ↑ 33% (based on population pharmacokinetic model)
Croatian: Istodobna sistemska primjena klotrimazola i pojačanog darunavira može povisiti koncentracije darunavira i/ili klotrimazola u plazmi. darunavir AUC24h ↑ 33% (na temelju populacijskog farmakokinetičkog modela)
English: Darunavir: comparison of darunavir/ritonavir 400/100 mg twice daily vs. darunavir/ritonavir 400/100 mg twice daily in combination with atazanavir 300 mg once daily.
Croatian: Darunavir: usporedba darunavira/ritonavira 400/100 mg dvaput na dan naspram darunavira/ritonavira 400/100 mg dvaput na dan u kombinaciji s atazanavirom 300 mg jedanput na dan.
English: Co-administration of darunavir with low dose ritonavir and alfuzosin is contraindicated (see section 4.3).
Croatian: Istodobna primjena darunavira s niskom dozom ritonavira i alfuzozinom je kontraindicirana (vidjeti dio 4.3).
English: median CD4+ cell count change from baseline (x 10
Croatian: Medijan promjene broja CD4+ stanica od početne vrijednosti (x 10
English: once daily N=294
Croatian: razlike) jedanput na dan N=343
English: Each film-coated tablet contains 400 mg darunavir.
Croatian: Jedna filmom obložena tableta sadrži 400 mg darunavira.
English: EU/1/17/1249/005 30 film-coated tablets EU/1/17/1249/006 60 film-coated tablets EU/1/17/1249/007 90 film-coated tablets EU/1/17/1249/008 180 film-coated tablets
Croatian: EU/1/17/1249/005 30 filmom obloženih tableta EU/1/17/1249/006 60 filmom obloženih tableta EU/1/17/1249/007 90 filmom obloženih tableta EU/1/17/1249/008 180 filmom obloženih tableta
English: ART-naïve paediatric patients (3 to 17 years of age and weighing at least 40 kg) The recommended dose regimen is 800 mg once daily with ritonavir 100 mg once daily taken with food.
Croatian: Odrasli bolesnici koji nisu prethodno liječeni antiretrovirusnom terapijom (ART-om) Preporučeni režim doziranja je 800 mg jedanput na dan uz 100 mg ritonavira jedanput na dan uzeto s hranom.
English: Musculoskeletal and connective tissue disorders uncommon myalgia, osteonecrosis, muscle spasms, muscular weakness, arthralgia, pain in extremity, osteoporosis, increased blood creatine phosphokinase rare musculoskeletal stiffness, arthritis, joint stiffness
Croatian: DRESS, Stevens-Johnsonov sindrom, multiformni eritem, dermatitis, seboroični dermatitis, kožne lezije, kseroderma nepoznato toksična epidermalna nekroliza, akutna generalizirana egzantematozna pustuloza Poremećaji mišićno-koštanog sustava i vezivnog tkiva manje često mialgija, osteonekroza, mišićni spazmi, mišićna slabost, artralgija, bol u ekstremitetima, osteoporoza, povišena kreatin-fosfokinaza u krvi rijetko mišićno-koštana ukočenost, artritis, ukočenost zglobova
English: Third trimester of pregnancy (n=12)
Croatian: Treće tromjesečje trudnoće (n=12)
English: Clinical monitoring is recommended when co-administering darunavir with low dose ritonavir with these analgesics.
Croatian: Preporučeno je kliničko praćenje kada se istodobno primjenjuju ovi analgetici s darunavirom s niskom dozom ritonavira.
English: EU/1/17/1249/001 30 film-coated tablets EU/1/17/1249/002 60 film-coated tablets EU/1/17/1249/003 90 film-coated tablets EU/1/17/1249/004 180 film-coated tablets
Croatian: EU/1/17/1249/001 30 filmom obloženih tableta EU/1/17/1249/002 60 filmom obloženih tableta EU/1/17/1249/003 90 filmom obloženih tableta EU/1/17/1249/004 180 filmom obloženih tableta
English: not known toxic epidermal necrolysis*, acute generalised exanthematous pustulosis*
Croatian: nepoznato toksična epidermalna nekroliza*, akutna generalizirana egzantematozna pustuloza* Poremećaji mišićno-koštanog sustava i vezivnog tkiva često mijalgija manje često osteonekroza*
English: Darunavir Krka 600 mg film-coated tablets darunavir
Croatian: Darunavir Krka 600 mg filmom obložene tablete darunavir
English: Outcomes darunavir / ritonavir 600/100 mg twice daily n=131
Croatian: Ishodi darunavir/ritonavir 600/100 mg dvaput na dan n=131
English: Rifapentine, rifabutin (medicines to treat some infections such as tuberculosis) Saquinavir (HIV infection).
Croatian: fenobarbital, fenitoin (sprječavaju epileptičke napadaje) deksametazon (kortikosteroid) efavirenz (HIV infekcija) boceprevir (infekcija hepatitisom C) rifapentin, rifabutin (lijekovi za liječenje nekih infekcija poput tuberkuloze) sakvinavir (HIV infekcija).
English: Darunavir/ritonavir 800/100 mg once daily in ART-experienced patients should not be used in patients with one or more darunavir resistance associated mutations (DRV-RAMs) or HIV-1 RNA ≥ 100,000 copies/ml or CD4+ cell count < 100 cells x 10
Croatian: Među bolesnicima prethodno liječenim ART-om, darunavir/ritonavir od 800/100 mg jedanput na dan ne smije se primjenjivati u bolesnika s jednom ili više mutacija povezanih s rezistencijom na darunavir (DRV-RAM) ili s HIV-1 RNK ≥ 100 000 kopija/ml ili brojem CD4+ stanica < 100 stanica x 10
English: Hence, concomitant use of darunavir coadministered with low dose ritonavir and the combination product lopinavir/ritonavir is contraindicated (see section 4.3).
Croatian: Odavde proizlazi da je istodobna primjena darunavira s niskom dozom ritonavira i kombiniranog lijeka lopinavira/ritonavira kontraindicirana (vidjeti dio 4.3).
English: darunavir/ ritonavir 600/100 mg twice daily N=298
Croatian: darunavir/ritonavir 600/100 mg dvaput na dan N=298
English: Darunavir co-administered with low dose ritonavir and amiodarone, bepridil, dronedarone, ivabradine, quinidine, or ranolazine is contraindicated (see section 4.3).
Croatian: Istodobna primjena darunavira istodobno primijenjenog s niskom dozom ritonavira i amiodarona, bepridila, dronedarona, ivabradina, kinidina ili ranolazina je kontraindicirana (vidjeti dio
English: General disorders and administration site conditions common asthenia, fatigue uncommon pyrexia, chest pain, peripheral oedema, malaise, feeling hot, irritability, pain rare chills, abnormal feeling, xerosis
Croatian: Nuspojava manje često pireksija, bol u prsištu, periferni edem, malaksalost, osjećaj vrućine, iritabilnost, bol rijetko zimica, nenormalno osjećanje, kseroza
English: Concomitant use of colchicine and darunavir co-administered with low dose ritonavir may increase the exposure to colchicine.
Croatian: Istodobna primjena kolhicina i darunavira primijenjenog istodobno s niskom dozom ritonavira može povećati izloženost kolhicinu. (inhibicija CYP3A i/ili P-gp-a)
English: It is not recommended to combine darunavir co-administered with low dose ritonavir with saquinavir.
Croatian: Ne preporučuje se istodobna primjena darunavira primijenjenog istodobno s niskom dozom ritonavira u kombinaciji sa sakvinavirom.
English: Abacavir Emtricitabine Lamivudine Stavudine Zidovudine
Croatian: Abakavir Emtricitabin Lamivudin Stavudin Zidovudin
English: Co-administration of boosted darunavir with dapoxetine is contraindicated.
Croatian: Istodobna primjena pojačanog darunavira s dapoksetinom je kontraindicirana.
English: Darunavir Krka 400 mg and 800 mg tablets can be used to construct the once daily 800 mg regimen.
Croatian: Tablete Darunavir Krka od 400 mg i 800 mg mogu se uzimati za dostizanje jednokratne doze od 800 mg.
English: Darunavir co-administered with low dose ritonavir and atazanavir can be used without dose adjustments.
Croatian: Darunavir istodobno primijenjen s niskom dozom ritonavira i atazanavirom može se primijeniti bez prilagodbe doze.
English: concomitantly administered with boosted darunavir.
Croatian: Istodobna primjena kolhicina i pojačanog darunavira
English: The strong CYP3A inducers rifampicin and herbal preparations containing St John's wort (Hypericum perforatum).
Croatian: - kombinacija lijekova lopinavir/ritonavir (vidjeti dio 4.5). - snažni CYP3A induktori, rifampicin i biljni pripravci koji sadrže gospinu travu (Hypericum perforatum).
English: Darunavir Krka 400 mg film-coated tablets Darunavir Krka 800 mg film-coated tablets darunavir
Croatian: Darunavir Krka 400 mg filmom obložene tablete Darunavir Krka 800 mg filmom obložene tablete darunavir
English: Clinical monitoring is recommended when co-administering boosted darunavir with these analgesics.
Croatian: Preporučeno je kliničko praćenje kada se istodobno primjenjuju ovi analgetici s pojačanim darunavirom.
English: Darunavir Krka 400 mg film-coated tablets darunavir
Croatian: Darunavir Krka 400 mg filmom obložene tablete darunavir
English: The pharmacokinetics of darunavir in combination with ritonavir taken once daily in 10 treatmentexperienced paediatric patients, aged 3 to < 6 years and weighing at least 14 kg to < 20 kg, showed that weight-based dosages resulted in darunavir exposure that was comparable to that achieved in adults receiving darunavir/ritonavir 800/100 mg once daily (see section 4.2).
Croatian: Farmakokinetika darunavira u kombinaciji s ritonavirom uzetih jedanput na dan, u 10 pedijatrijskih prethodno liječenih bolesnika, u dobi od 3 do < 6 godina i težine najmanje 14 kg do < 20 kg, pokazala je da je doziranje temeljeno na težini rezultiralo izloženošću darunaviru, sličnoj onoj postignutoj u odraslih koji su uzimali darunavir/ritonavir 800/100 mg jedanput na dan (vidjeti dio 4.2).
English: Boosted darunavir and dolutegravir can be used without dose adjustment.
Croatian: Pojačan darunavir i dolutegravir mogu se uzimati bez prilagodbe doze.
English: Darunavir Krka 800 mg film-coated tablets darunavir
Croatian: Darunavir Krka 800 mg filmom obložene tablete darunavir
English: Darunavir is expected to increase these β-blocker plasma concentrations.
Croatian: Očekuje se da će darunavir povećati koncentracije tih β-blokatora u plazmi. (CYP2D6 inhibicija)
English: Concomitant use of everolimus and darunavir co-administered with low dose ritonavir is not recommended.
Croatian: Istodobna primjena everolimusa i darunavira istodobno primijenjenog s niskom dozom ritonavira se ne preporučuje.
English: Darunavir used in combination with cobicistat or low dose ritonavir once daily in ART-experienced patients should not be used in patients with one or more darunavir resistance associated mutations (DRV-RAMs) or HIV-1 RNA ≥ 100,000 copies/ml or CD4+ cell count < 100 cells x 10
Croatian: Darunavir koji se uzima u kombinaciji s kobicistatom ili niskom dozom ritonavira jedanput na dan, u ART-om prethodno liječenih bolesnika, ne smije se primjenjivati u onih bolesnika koji imaju jednu ili više mutacija povezanih s rezistencijom na darunavir (DRV-RAM, od engl. darunavir resistance associated mutations) ili HIV-1 RNK ≥ 100 000 kopija/ml ili broj CD4+ stanica < 100 stanica x 10
English: Dose for children 3 years of age and above, weighing more than 40 kilograms who have not taken antiretroviral medicines before (your child's doctor will determine this) The usual dose of Darunavir Krka is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) together with 100 milligram ritonavir once daily.
Croatian: Doza za djecu u dobi od 3 godine i više, težine najmanje 40 kilograma koja nisu prethodno uzimala antiretrovirusne lijekove (to će odrediti liječnik Vašeg djeteta) - Uobičajena doza lijeka Darunavir Krka je 800 miligrama (2 tablete koje sadrže
English: Concomitant use of salmeterol and darunavir co-administered with low dose ritonavir is not recommended.
Croatian: Ne preporučuje se istodobna primjena salmeterola i darunavira primijenjenog istodobno s niskom dozom ritonavira.
English: Sildenafil to treat high blood pressure in the pulmonary circulation
Croatian: - sildenafil - kada se primjenjuje za liječenje plućne arterijske hipertenzije,
English: darunavir/ ritonavir 800/100 mg once daily N=294
Croatian: darunavir/ritonavir 800/100 mg jedanput na dan N=294
English: Yellowish brown, oval, biconvex film-coated tablets (tablets), engraved with a mark S1 on one side.
Croatian: Žućkastosmeđe, ovalne, bikonveksne filmom obložene tablete (tablete), s utisnutom oznakom S1 na jednoj strani.
English: Darunavir: comparison of darunavir/ritonavir 400/100 mg twice daily vs. darunavir/ritonavir 400/100 mg in combination with indinavir 800 mg twice daily.
Croatian: Darunavir: usporedba darunavira/ritonavira 400/100 mg dvaput na dan naspram darunavira/ritonavira 400/100 mg u kombinaciji s indinavirom 800 mg dvaput na dan.
English: ART-naïve paediatric patients from the age of 12 years to < 18 years, and weighing at least 40 kg DIONE is an open-label, Phase II trial evaluating the pharmacokinetics, safety, tolerability, and efficacy of darunavir with low dose ritonavir in 12 ART-naïve HIV-1 infected paediatric patients aged 12 to less than 18 years and weighing at least 40 kg.
Croatian: DIONE je otvoreno ispitivanje faze II koje je procijenilo farmakokinetiku, sigurnost, podnošljivost i djelotvornost darunavira s niskom dozom ritonavira u 12 pedijatrijskih bolesnika koji nisu prethodno liječeni ART-om, u dobi od 12 godina do < 18 godina i težine najmanje 40 kg.
English: Orangish brown, oval, biconvex film-coated tablets, engraved with a mark S2 on one side.
Croatian: Narančastosmeđe, ovalne, bikonveksne filmom obložene tablete, s utisnutom oznakom S2 na jednoj strani.
English: The pharmacokinetics of darunavir in combination with ritonavir taken twice daily in 74 treatmentexperienced paediatric patients, aged 6 to 17 years and weighing at least 20 kg, showed that the administered weight-based doses of darunavir/ritonavir resulted in darunavir exposure comparable to that in adults receiving darunavir/ritonavir 600/100 mg twice daily (see section 4.2).
Croatian: Farmakokinetika darunavira u kombinaciji s ritonavirom uzetih dva puta na dan, u 74 prethodno liječena pedijatrijska bolesnika u dobi 6 do 17 godina i težinom najmanje 20 kg, pokazala je da primjena darunavira/ritonavira s doziranjem ovisnim o tjelesnoj težini rezultira izloženošću darunaviru koja je usporediva s onom u odraslih koji primaju darunavir/ritonavir od 600/100 mg dvaput na dan (vidjeti dio 4.2).
English: Amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine to treat certain heart disorders e.g. abnormal heart beat Lovastatin, simvastatin and lomitapide to lower cholesterol levels Rifampicin to treat some infections such as tuberculosis
Croatian: liječenje gihta ili obiteljske mediteranske vrućice lurasidon, pimozid, kvetiapin ili sertindol liječenje psihijatrijskih stanja ergot alkaloidi kao što su ergotamin, dihidroergotamin, ergometrin i metilergonovin liječenje migrenskih glavobolja amiodaron, bepridil, dronedaron, ivabradin, kinidin i ranolazin liječenje određenih srčanih poremećaja npr. abnormalni otkucaji srca lovastatin, simvastatin i lomitapid snižavanje razina kolesterola rifampicin liječenje nekih infekcija poput tuberkuloze kombinirani lijek lopinavir/ritonavir ovaj lijek protiv HIV-a pripada istoj skupini kao i Darunavir Krka elbasvir/grazoprevir liječenje infekcije hepatitisom C
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with darunavir coadministered with low dose ritonavir is required.
Croatian: Ako je potrebno liječenje darunavirom istodobno primjenjenim s niskom dozom ritonavira, preporučuje se smanjiti dozu kolhicina ili prekinuti liječenje kolhicinom u bolesnika s normalnom funkcijom bubrega ili jetre.