FrancophonIA/ELRC3.0 huggingface dataset:
English: What Efexor depot is and what is used for Before you take Efexor depot How to take Efexor depot Possible side effects
Slovenian: Kaj je zdravilo Efexor depot in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Efexor depot Kako jemati zdravilo Efexor depot Možni neželeni učinki
English: Treatment of major depressive episodes.
Slovenian: Zdravljenje hudih depresivnih epizod.
English: Portugal (Farma), Lda.
Slovenian: Portugalska Wyeth Lederle Portugal (Farma), Lda.
English: Denmark Wyeth AB Dalvägen 12
Slovenian: Wyeth AB Dalvägen 12
English: Efexor depot passes into breast milk.
Slovenian: Zdravilo Efexor depot prehaja v materino mleko.
English: Your doctor should decide whether you can take Efexor depot with other medicines.
Slovenian: Vaš zdravnik bo presodil, ali lahko jemljete zdravilo Efexor depot skupaj z drugimi zdravili.
English: Capsules must be swallowed whole with fluid and not opened, crushed, chewed or dissolved.
Slovenian: Kapsule morate pogoltniti cele skupaj s tekočino in jih ne smete odpreti, zdrobiti, žvečiti ali raztopiti.
English: These spheroids are released from the capsule into your gastrointestinal tract.
Slovenian: Ti sferoidi se sprostijo iz kapsule v vaša prebavila.
English: The usual recommended starting dose for treatment of depression, generalised anxiety disorder and social anxiety disorder is 75 mg per day.
Slovenian: Običajni priporočeni začetni odmerek za zdravljenje depresije, generalizirane anksiozne motnje in socialne anksiozne motnje je 75 mg na dan.
English: • Muscle disorders Not known: unexplained muscle pain, tenderness or weakness (rhabdomyolysis)
Slovenian: • Bolezni mišic Neznana: nepojasnjene bolečine v mišicah, občutljivost ali oslabelost rabdomioliza)
English: • If you have a history of, or if someone in your family has had, mania or bipolar disorder
Slovenian: • če ste kdaj imeli, če kdo v vaši družini ima ali je imel manijo ali bipolarno motnjo (občutek prekomernega razburjenja ali pretirano dobrega počutja);
English: - “treatment of panic disorders with or without agoraphobia”, given that the data derived from the studies presented provided sufficient evidence for the efficacy and safety of venlafaxine in this indication;
Slovenian: - „zdravljenje paničnih motenj z agorafobijo ali brez nje“ glede nato, da so predložene študije ustrezno potrdile klinično učinkovitost in varnost uporabe venlafaksina pri tej indikaciji;
English: Also, you must wait at least 7 days after you stop taking Efexor depot before you take any MAOI (see also the sections “Serotonin syndrome” and “Taking other medicines”).
Slovenian: Po prekinitvi jemanja zdravila Efexor depot morate počakati vsaj 7 dni, preden začnete uporabljati katerikoli zaviralec MAO (glejte tudi poglavji “Serotoninski sindrom” in “Jemanje drugih zdravil”).
English: Luxembourg Wyeth Pharmaceuticals SA/NV Rue du Bosquet,15
Slovenian: Luksemburg Wyeth Pharmaceuticals SA/NV Rue du Bosquet,15
English: Efficacy was also established in one long-term double-blind, placebo-controlled, parallel-group study of the long-term safety, efficacy, and prevention of relapse in adult outpatients who responded to open-label treatment.
Slovenian: Učinkovitost je bila dokazana tudi v dolgoročni, dvojno slepi, s placebom nadzorovani raziskavi s paralelnimi skupinami, za ugotavljanje dolgoročne varnosti, učinkovitosti in preprečevanja ponovitev, ki je bila izvedena pri ambulantno zdravljenih, odraslih bolnikih, ki so se odzvali na odprto zdravljenje.
English: Withdrawal symptoms, when treatment is discontinued, are common, particularly if discontinuation is abrupt (see section 4.8).
Slovenian: Pri prekinitvi zdravljenja so odtegnitveni učinki pogosti, še posebej, če je prekinitev nenadna (glejte poglavje 4.8).
English: It is recommended that venlafaxine prolonged-release capsules be taken with food, at approximately the same time each day.
Slovenian: Priporočljivo je, da bolnik venlafaksin v obliki kapsul s podaljšanim sproščanjem jemlje skupaj s hrano, vsak dan ob približno istem času.
English: Patients then received fixed doses of 75 or 150 mg/day in one study and 75 or 225 mg/day in the other study.
Slovenian: Nato so bolniki prejemali stalne odmerke po 75 ali 150 mg/dan v prvi raziskavi in 75 ali 225 mg/dan v drugi raziskavi.
English: Generalised Anxiety Disorder (GAD): it was agreed that the long term efficacy of prolonged-release venlafaxine in the GAD indication was supported by the data provided.
Slovenian: Generalizirana anksiozna motnja (GAM): sprejeto je bilo, da predloženi podatki potrjujejo dolgoročno učinkovitost venlafaksina s podaljšanim sproščanjem pri indikaciji generalizirane anksiozne motnje.
English: Therefore, even though you may see spheroids in your stools, your dose of venlafaxine has been absorbed.
Slovenian: Kljub sferoidom v blatu, ste lahko prepričani, da se je vaš odmerek venlafaksina absorbiral.
English: Efexor depot sometimes causes unwanted effects that you may not be aware of, such as increases in blood pressure or abnormal heart beat; slight changes in blood levels or liver enzymes, sodium or cholesterol.
Slovenian: Zdravilo Efexor depot včasih povzroča neželene učinke, ki se jih ne zavedate, na primer zvišanje krvnega tlaka ali nenormalen srčni ritem; majhne spremembe ravni jetrnih encimov, natrija ali holesterola v krvi.
English: Withdrawal symptoms seen on discontinuation of venlafaxine: based on a proposed text for the SPC for for Selective Serotonin Reuptake Inhibitors (SSRIs) / Selective Norepinephrine Reuptake Inhibitors (SNRIs) (Sections 4.2, 4.4, and 4.8) reviewed by the Pharmacovigilance Working Party, it was agreed to incorporate this text into the harmonised SPC.
Slovenian: Odtegnitveni simptomi ob prenehanju jemanja venlafaksina: na podlagi predlaganega besedila za povzetek glavnih značilnosti zdravila za selektivne zaviralce ponovnega prevzema serotonina (SSRI)/zaviralce prevzema serotonina in noradrenalina (SNRI) (poglavja 4.2, 4.4 in 4.8), ki ga je proučila delovna skupina za farmakovigilanco, je bilo dogovorjeno, da se to besedilo vključi v usklajen povzetek glavnih značilnosti zdravila.
English: Efexor depot should be taken with food (see section 3 “HOW TO TAKE EFEXOR DEPOT”).
Slovenian: Zdravilo Efexor depot je treba jemati skupaj s hrano (glejte poglavje 3 “KAKO JEMATI ZDRAVILO EFEXOR DEPOT”).
English: Use in patients with renal impairment: it was agreed that the individualisation of the dosage may be desirable, and this concept was introduced in the text for harmonization.
Slovenian: Uporaba pri bolnikih z okvaro ledvic: sprejeto je bilo, da je zaželeno določanje odmerka za vsakega bolnika posebej, to priporočilo pa je bilo vključeno v usklajeno besedilo.
English: Efexor depot may cause a sensation of restlessness or an inability to sit or stand still.
Slovenian: Zdravilo Efexor depot lahko povzroči občutek nemira ali nezmožnost mirnega sedenja ali stanja.
English: Inside Efexor depot capsules are spheroids or small white balls that contain the venlafaxine active ingredient.
Slovenian: V kapsulah zdravila Efexor depot so sferoidi ali majhne bele kroglice, ki vsebujejo zdravilno učinkovino venlafaksin.
English: Your doctor will advise you on how you should gradually discontinue Efexor depot treatment.
Slovenian: Zdravnik vam bo svetoval, kako postopoma ukinete zdravljenje z zdravilom Efexor depot.
English: SPC Section 4.5 - Interaction with other medicinal products and other forms of interaction
Slovenian: Povzetek glavnih značilnosti zdravila, poglavje 4.5: Medsebojno delovanje z drugimi zdravili in druge oblike interakcij
English: A warning on the use of Efexor depot in the treatment of children and adolescents under the age of 18 years was also agreed upon and introduced in Section 4.4.
Slovenian: Sprejeto je bilo tudi opozorilo glede uporabe zdravila Efexor depot pri zdravljenju otrok in mladostnikov, mlajših od 18 let, ki je bilo vključeno v poglavje 4.4 povzetka glavnih značilnosti zdravila.
English: The insoluble portion of these spheroids is eliminated and may be seen in faeces.
Slovenian: Netopni del teh sferoidov se iz telesa izloči in ga je moč videti v blatu.
English: the MAH was asked to discuss the risk/benefit for the panic indication in more detail, comparing the safety and efficacy for the 75 mg dose with the suggested 225 mg dose.
Slovenian: Panična motnja: imetnik dovoljenja za promet je bil naprošen, da podrobneje pojasni razmerje med tveganji in koristmi za indikacijo panike, in sicer ob primerjavi varnosti in učinkovitosti 75miligramskega odmerka s predlaganim 225-miligramskim odmerkom.
English: Efexor depot has been included in the list of products for Summary of Product Characteristics (SPC) harmonisation, drawn up by the CMD(h), in accordance with Article 30(2) of Directive 2001/83/EC, as amended.
Slovenian: Zdravilo Efexor depot je bilo vključeno na seznam zdravil za uskladitev povzetkov glavnih značilnosti zdravila (SPC), ki ga je v skladu s členom 30(2) Direktive 2001/83/ES, kakor je bila spremenjena, sestavila Usklajevalna skupina za postopek medsebojnega priznavanja in decentralizirani postopek (zdravila za uporabo v humani medicini).
English: Patients received doses in a range of 75 to 225 mg/day.
Slovenian: Bolniki so prejemali odmerke v razponu od 75 do 225 mg/dan.
English: As with other serotonergic agents, serotonin syndrome, a potentially life-threatening condition, may occur with venlafaxine treatment, particularly with concomitant use of other agents, such as MAO-inhibitors, that may affect the serotonergic neurotransmitter systems (see sections 4.3 and 4.5).
Slovenian: Kot pri drugih serotoninergičnih zdravilih, se lahko tudi pri zdravljenju z venlafaksinom pojavi potencialno življenjsko nevarni serotoninski sindrom, še posebej pri sočasni uporabi drugih zdravil, na primer zaviralcev MAO, ki lahko vplivajo na serotoninergične nevrotransmiterske sisteme (glejte poglavji 4.3 in 4.5).
English: • Monoamine oxidase inhibitors (MAOIs: see the section “Before you take Efexor depot”).
Slovenian: • Zaviralci monoaminooksidaze (zaviralci MAO: glejte poglavje “Kaj morate vedeti, preden boste vzeli zdravilo Efexor depot”).
English: Efexor depot should normally not be used for children and adolescents under 18 years.
Slovenian: Zdravilo Efexor depot se običajno ne sme uporabljati pri otrocih in mladostnikih, mlajših od 18 let.
English: Belgium Wyeth Pharmaceuticals SA/NV Rue du Bosquet,15
Slovenian: Wyeth Pharmaceuticals SA/NV Rue du Bosquet,15
English: A-1150 Vienna
Slovenian: A-1150 Dunaj
English: Following the European Commission's request, Section 4.1 of the Summary of Product Characteristics was harmonized to include the following therapeutic indications as worded and described below: - “treatment of major depressive episodes”, with no inclusion of references to associated anxiety, given that the studies designed to investigate the anxiolytic effect of venlafaxine revealed that it is difficult to distinguish anxiety from the concomitant depression disorder;
Slovenian: Povzetek glavnih značilnosti zdravila, poglavje 4.1: Terapevtske indikacije Na zahtevo Evropske komisije je bilo poglavje 4.1 povzetka glavnih značilnosti zdravila usklajeno in vključuje naslednje terapevtske indikacije s spodaj navedenim besedilom in opisom: - „zdravljenje hudih depresivnih epizod“ brez vključitve sklicevanj na povezano anksioznost, glede nato, da so študije, zasnovane za proučitev anksiolitskega učinka venlafaksina, pokazale, da je težko razlikovati med anksioznostjo in sočasnimi depresivnimi motnjami;
English: Panic disorder
Slovenian: Panična motnja
English: Also, the long-term safety effects concerning growth, maturation and cognitive and behavioural development of Efexor depot in this age group has not yet been demonstrated.
Slovenian: V tej starostni skupini dolgoročna varnost zdravila Efexor depot v zvezi z rastjo, dozorevanjem ter kognitivnim in vedenjskim razvojem še ni bila dokazana.
English: Side effects are known to occur when people stop using Efexor depot, especially when Efexor depot is stopped suddenly or the dose is reduced too quickly.
Slovenian: Pri prekinitvi zdravljenja z zdravilom Efexor depot se pojavijo neželeni učinki, še posebej pri nenadni ukinitvi zdravila Efexor depot ali pri prehitrem zniževanju odmerka.
English: Efexor depot should be taken with food.
Slovenian: Zdravilo Efexor depot je treba jemati skupaj s hrano.
English: Furthermore, a statement was included in the harmonized SPC to highlight that controlled studies in children did not demonstrate efficacy of venlafaxine in the “major depressive disorder” indication.
Slovenian: V usklajeni povzetek glavnih značilnosti zdravila je bila vključena tudi izjava, da se v nadzorovanih študijah pri indikaciji „hude depresivne motnje“ pri otrocih venlafaksin ni izkazal za učinkovito zdravilo.
English: In the harmonized text of Section 4.4 it is indicated that non-selective MAOIs should not be given concomitantly, and that reversible, selective MAOIs such as moclobemide are not recommended in combination with venlafaxine, due to the risk of serotonin syndrome.
Slovenian: V usklajenem besedilu poglavja 4.4 je navedeno, da sočasna uporaba neselektivnih zaviralcev monoaminskih oksidaz ni dovoljena ter da uporaba reverzibilnih selektivnih zaviralcev monoaminskih oksidaz, kot je moklobemid, v kombinaciji z venlafaksinom zaradi tveganja serotoninskega sindroma ni priporočena.
English: If you take more Efexor depot than you should
Slovenian: Če ste vzeli večji odmerek zdravila Efexor depot, kot bi smeli
English: - “treatment of generalized anxiety disorder (GAD)” excluding “treatment of special anxiety cases”, given that the latter is not a recognised DSM indication.
Slovenian: - „zdravljenje generalizirane anksiozne motnje (GAM)“ brez navedbe „zdravljenje posebnih primerov anksioznosti“, saj to po priročniku DSM (diagnostična in statistična klasifikacija duševnih motenj) ni priznano kot indikacija.
English: 12, B.O.BOX 1822, 17124 Solna Sweden
Slovenian: 12, B.O.BOX 1822, 17124 Solna Švedska
English: There was no evidence for any greater effectiveness of the 150 to 225 mg/day group compared to the 75 mg/day group in the 6-month study.
Slovenian: Večja učinkovitost odmerkov v skupini, ki je prejemala od 150 do 225 mg/dan v primerjavi s skupino, ki je prejemala 75 mg/dan, v 6-mesečni raziskavi ni bila dokazana.
English: DATE OF REVISION OF THE TEXT {MM/YYYY [To be completed nationally]
Slovenian: DATUM ZADNJE REVIZIJE BESEDILA {MM/LLLL} [Izpolni država članica.]
English: Do not stop taking Efexor depot without talking to your doctor (see the section “If you stop taking Efexor depot”).
Slovenian: Brez predhodnega posveta z zdravnikom ne smete prenehati jemati zdravila Efexor depot (glejte poglavje “Če ste prenehali jemati zdravilo Efexor depot”).
English: The spheroid “shell” remains undissolved and is eliminated in your stools.
Slovenian: “Ovojnica” sferoida se ne raztopi in se izloči z blatom.
English: Do not take more than the daily amount of Efexor depot that has been prescribed for you in one day.
Slovenian: V enem dnevu ne smete vzeti več zdravila Efexor depot, kot vam ga je zdravnik predpisal za en dan.
English: Despite this, your doctor may prescribe Efexor depot for patients under 18 because he/she decides that this is in their best interests.
Slovenian: Kljub temu pa lahko zdravnik zdravilo Efexor depot predpiše tudi bolniku, mlajšemu od 18 let, če presodi, da je takšno zdravljenje za bolnika koristno.
English: Efexor depot is an antidepressant that belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors (SNRIs).
Slovenian: Zdravilo Efexor depot je antidepresiv, ki spada v skupino zdravil, ki se imenujejo zaviralci ponovnega privzema serotonina in noradrenalina (SNRI).
English: Wyeth AB Box 1822, 171 24 Solna Sweden
Slovenian: Wyeth AB Box 1822, 171 24 Solna Švedska
English: How to store Efexor depot Further information
Slovenian: Shranjevanje zdravila Efexor depot Dodatne informacije
English: The MAH did not agree with the PhVWP/CMD(h) agreed SPC wording for all antidepressants for Section 4.8, since suicidal ideation is not considered an adverse reaction in adult patients, but agreed to comply with the mandated class labelling.
Slovenian: Imetnik dovoljenja za promet z zdravilom se ni strinjal z odobrenim besedilom delovne skupine za farmakovigilanco/Usklajevalne skupine za postopek medsebojnega priznavanja in decentralizirani postopek za zdravila za uporabo v humani medicini za vse antidepresive v poglavju 4.8, saj razmišljanje o samomoru ne spada med neželene učinke pri odraslih bolnikih, vendar je soglašal, da bo upošteval predpisano označevanje razredov.
English: Psychomotor restlessness was also added to the table of adverse reactions.
Slovenian: Na seznam neželenih učinkov zdravila je bila dodana tudi psihomotorična nemirnost.
English: SPC Section 4.2 - Posology and Method of Administration The MAH was asked to harmonise the following posology texts in the SPC: - limitations of treatment duration of the maximum daily dose of 375mg to 4 weeks; - differences in maximum recommended daily dose.
Slovenian: Povzetek glavnih značilnosti zdravila, poglavje 4.2: Odmerjanje in način uporabe Imetnik dovoljenja za promet z zdravilom je bil naprošen, da uskladi naslednja besedila o odmerjanjih v povzetku glavnih značilnosti zdravila: - omejitev trajanja zdravljenja z največjim dnevnim odmerkom 375 mg na 4 tedne; - razlike v največjih priporočenih dnevnih odmerkih.
English: SPC Section 4.4 - Special Warnings and Precautions for Use The MAH was asked to harmonise Section 4.4, for which the following differences between SPCs needed to be evaluated: - the mentioning of reports of aggression in relation to starting and discontinuing treatment; - treatment of children and adolescents under the age of 18, which was recommended by the CHMP in 2005 to be included in Section 4.4 of the SPC (Commission Decision of 19-VIII-2005); With regards to the aggression reports, it was agreed to introduce a wording to indicate that aggression may occur in patients receiving venlafaxine, under initiation, dose changes and discontinuation of treatment.
Slovenian: Povzetek glavnih značilnosti zdravila, poglavje 4.4: Posebna opozorila in previdnostni ukrepi Imetnik dovoljenja za promet z zdravilom je bil naprošen, da uskladi poglavje 4.4, v katerem je treba oceniti naslednja neskladja med povzetki glavnih značilnosti zdravila: - omemba poročil o agresivnosti, povezani s pričetkom ali prekinitvijo jemanja zdravila; - zdravljenje otrok in mladostnikov, mlajših od 18 let; CHMP je leta 2005 priporočil, da se to vključi v poglavje 4.4 povzetka glavnih značilnosti zdravila (Sklep Komisije z dne 19. 7. 2005); - varnost srca in ožilja (povečano tveganje za srčno ventrikularno aritmijo in nenadzorovano hipertenzijo).
English: Some patients may experience symptoms such as tiredness, dizziness, light-headedness, headache, sleeplessness, nightmares, dry mouth, loss of appetite, nausea, diarrhoea, nervousness, agitation, confusion, ringing in the ears, tingling or rarely electric shock sensations, weakness, sweating, seizures, or flu-like symptoms.
Slovenian: Pri nekaterih bolnikih se lahko pojavijo simptomi, kot so utrujenost, vrtoglavica, omotica, glavobol, nespečnost, nočne more, suha usta, neješčnost, siljenje na bruhanje, driska, živčnost, vznemirjenost, zmedenost, zvonjenje v ušesih, mravljinčenje in redko občutki električnega udarca, oslabelost, znojenje, epileptični napadi ali gripi podobni simptomi.
English: As the spheroids travel the length of your gastrointestinal tract, venlafaxine is slowly released.
Slovenian: Ko sferoidi potujejo po prebavni cevi, se iz njih venlafaksin sprošča počasi.
English: Efexor depot should not be used in the treatment of children and adolescents under the age of 18 years.
Slovenian: Zdravila Efexor depot se ne sme uporabljati pri otrocih in mladostnikih, mlajših od 18 let.
English: Social anxiety disorder
Slovenian: Socialna anksiozna motnja
English: Venlafaxine prolonged-release capsules contain spheroids, which release the active substance slowly into the digestive tract.
Slovenian: Venlafaksin kapsule s podaljšanim sproščanjem vsebujejo sferoide, ki počasi sproščajo zdravilno učinkovino v prebavila.
English: the CHMP has recommended the amendment of the Marketing Authorisations for which the Summary of Product Characteristics, labelling and package leaflet are set out in Annex III for Efexor depot and associated names (see Annex I).
Slovenian: je Odbor za zdravila za uporabo v humani medicini priporočil dopolnilo dovoljenj za promet z zdravilom Efexor depot in z njim povezanih imen, za katera so v Dodatku III določeni povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo (glejte Dodatek I).
English: The MAH was asked to harmonise Section 4.5 in the Summary of Product Characteristics, for which the following differences between SPCs needed to be evaluated: - monoamine oxidase inhibitors.
Slovenian: Imetnik dovoljenja za promet z zdravilom je bil naprošen, da uskladi poglavje 4.5 povzetka glavnih značilnosti zdravila, v katerem je treba oceniti naslednja neskladja med povzetki glavnih značilnosti zdravila: - zaviralci monoaminske oksidaze.
English: Therefore, you should discuss the matter with your doctor, and he/she will decide whether you should stop breast-feeding or stop the therapy with Efexor depot.
Slovenian: Potrebno se je posvetovati z vašim zdravnikom, ki bo presodil, ali boste prenehali dojiti ali prenehali z zdravljenjem z zdravilom Efexor depot.
English: Monoamine Oxidase Inhibitors (MAOI)
Slovenian: Zaviralci monoaminooksidaz (MAO)
English: You should use Efexor depot only after discussing the potential benefits and the potential risks to your unborn child with your doctor.
Slovenian: Pred uporabo zdravila Efexor depot je potrebno pretehtati morebitne koristi zdravljenja za žensko glede na morebitna tveganja za nerojenega otroka.
English: Treatment of social anxiety disorder.
Slovenian: Zdravljenje socialne anksiozne motnje.
English: Prolonged-release capsule, hard
Slovenian: kapsula s podaljšanim sproščanjem, trda
English: The efficacy of venlafaxine prolonged-release capsules as a treatment for panic disorder was established in two double-blind, 12-week, multi-center, placebo-controlled studies in adult outpatients with panic disorder, with or without agoraphobia.
Slovenian: Učinkovitost venlafaksina s podaljšanim sproščanjem v obliki kapsul pri zdravljenju panične motnje je bila dokazana v dveh dvojno slepih, 12-tedenskih, multicentričnih, s placebom nadzorovanih raziskavah, pri ambulantno zdravljenih, odraslih bolnikih s panično motnjo, z agorafobijo ali brez nje.
English: Therefore, a decision to continue/discontinue breast-feeding or to continue/discontinue therapy with Efexor depot should be made, taking into account the benefit of breast-feeding to the child and the benefit of Efexor depot therapy to the woman.
Slovenian: Potrebno je pretehtati korist dojenja za otroka in korist zdravljenja z zdravilom Efexor depot za mater in na podlagi tega sprejeti odločitev o nadaljevanju ali prekinitvi dojenja in nadaljevanju ali prekinitvi zdravljenja z zdravilom Efexor depot.
English: As with other serotonergic agents, serotonin syndrome may occur with venlafaxine treatment, particularly with concomitant use of other agents that may affect the serotonergic neurotransmitter system (including triptans, SSRIs, SNRIs, lithium, sibutramine, tramadol, or St. John's Wort [Hypericum perforatum]), with medicinal agents which impair metabolism of serotonin (including MAOIs), or with serotonin precursors (such as tryptophan supplements).
Slovenian: Kot pri drugih serotoninergičnih zdravilih, se lahko tudi pri zdravljenju z venlafaksinom pojavi serotoninski sindrom, še posebej pri sočasni uporabi drugih zdravil, ki lahko vplivajo na serotoninergični nevrotransmiterski sistem (vključno s triptani, selektivnimi zaviralci privzema serotonina (SSRI, selective serotonin reuptake inhibitors), zaviralci privzema serotoninanoradrenalina (SNRI, serotonin noradrenalin reuptake inhibitors), litijem, sibutraminom, tramadolom in šentjanževko (Hypericum perforatum), zdravili, ki vplivajo na presnovo serotonina (vključno z zaviralci MAO) ali prekurzorji serotonina (kot so nadomestki triptofana).