FrancophonIA/ELRC3.0 huggingface dataset:
English: Some patients with Dupuytren's contracture developed IgE-anti-drug antibodies in greater proportions and higher titers with successive Xiapex injections.
Croatian: Neki bolesnici s Dupuytrenovom kontrakturom razvili su IgE protutijela na lijek u većoj mjeri i u višem titru nakon uzastopnih injekcija Xiapexa.
English: • Mark the point with a surgical marker.
Croatian: • Obilježite točku kirurškim flomasterom.
English: • muscle spasm, muscle weakness, musculoskeletal stiffness or discomfort
Croatian: • mišićni grčevi, mišićna slabost, mišićno-koštana ukočenost ili nelagoda
English: • Gently pull your penis away from your body to its full length and hold the stretch for
Croatian: • Nježno vucite penis od tijela dok ne dosegne punu duljinu i držite ga istegnutog 30 sekundi.
English: The mITT population was defined as all randomized subjects who had both a penile curvature deformity measurement and a PDQ assessment at baseline and at one or more subsequent time points.
Croatian: *mITT populacija bila je definirana kao svi randomizirani ispitanici koji su prošli i mjerenje deformirajuće zakrivljenosti penisa i procjenu PDQ upitnikom na početku ispitivanja i još jednom ili više puta tijekom ispitivanja.
English: At the follow-up visit approximately 24-72 hours after injection, it should be determined if the contracture has resolved.
Croatian: Na kontrolnom posjetu približno 24-72 sata nakon injekcije treba utvrditi je li kontraktura nestala.
English: Xiapex contains sodium
Croatian: Xiapex sadrži natrij
English: Use of Xiapex in patients who have received anticoagulants (with the exception of up to 150 mg acetylsalicylic acid daily) within 7 days prior to receiving an injection of Xiapex is not recommended.
Croatian: Ne preporučuje se primjena Xiapexa u bolesnika koji su primili antikoagulanse (osim acetilsalicilne kiseline u dozi do 150 mg na dan) u razdoblju od 7 dana prije primanja injekcije Xiapexa.
English: In addition to the in-office penile modelling procedure, patients should be provided instructions on the appropriate technique to self-perform penile modelling activities at home each day for the 6-week period following the physician penile plaque modelling visit of each treatment cycle, according to the detailed instructions provided in the package leaflet.
Croatian: Kao dodatak ambulantnom postupku modeliranja penisa, bolesnicima treba dati upute za odgovarajuće samostalno svakodnevno izvođenje tehnike modeliranja penisa kod kuće u razdoblju od 6 tjedana nakon posjeta na kojem je liječnik napravio postupak modeliranja plaka penisa u svakom ciklusu liječenja, prema detaljnim uputama koje se nalaze u uputi o lijeku.
English: At the follow-up visit 1 to 3 days after the second injection of each treatment cycle, the trained physician should perform a penile modelling procedure on the flaccid penis to stretch and elongate the treated plaque that Xiapex has disrupted.
Croatian: Na kontrolnom posjetu 1 do 3 dana nakon druge injekcije svakog ciklusa liječenja, obučeni liječnik treba provesti postupak modeliranja penisa na opuštenom penisu kako bi se plak razgrađen Xiapexom rastegnuo i produljio.
English: If the solution contains particles, is cloudy or discoloured, it should not be injected.
Croatian: Ako otopina sadrži čestice, zamućena je ili je promijenila boju, ne smije se ubrizgati.
English: Clinical study experience with Xiapex is currently limited to four treatment cycles in which a total of 8 injections may be administered into the plaque causing the curvature.
Croatian: Iskustvo s Xiapexom u kliničkim ispitivanjima trenutno je ograničeno na četiri ciklusa liječenja u kojima se može primijeniti najviše 8 injekcija u plak koji uzrokuje zakrivljenost.
English: Each vial of Xiapex and sterile solvent for reconstitution should only be used for a single injection.
Croatian: Jedna bočica Xiapexa i sterilnog otapala za rekonstituciju smije se koristiti za pripremu samo jedne injekcije.
English: a Baseline was defined as the last observation prior to the first injection of Xiapex in the previous phase 3 study (i.e AUX-CC-802, AUX-CC-803, AUX-CC-804 or AUX-CC-806) b Reference was defined as the last post-baseline non-missing observed value from the previous phase 3 study (i.e AUX-CC-802, AUX-CC-803, AUX-CC-804 or AUX-CC-806) * Note: 29 subjects were excluded from this analysis.
Croatian: Početna vrijednost definirana je kao zadnja opažena vrijednost prije prve injekcije Xiapexa u prethodnom ispitivanju faze III (tj., u ispitivanju AUX-CC-802, AUX-CC-803, AUX-CC-804 ili AUX-CC-806) b Referentna vrijednost definirana je kao zadnja dostupna vrijednost nakon početne vrijednosti opažena u prethodnom ispitivanju faze III (tj. ispitivanju AUX-CC-802, AUX-CC-803, AUX-CC-804 ili AUXCC-806)
English: Peyronie's Disease Questionnaire (PDQ)b,Mean Patient-Reported PD Bother Domain Score (range: 0-16) c
Croatian: Upitnik za Peyronijevu bolest (PDQ)b, - Srednji broj bodova u dijelu "tegobe" zabilježen od strane bolesnika (raspon: 0-16) c
English: MP Jointsa
Croatian: MP zglobovia
English: The following information is intended for healthcare professionals only: Instructions for use and handling
Croatian: Sljedeće informacije namijenjene su samo zdravstvenim radnicima:
English: Tell your doctor right away if you have trouble stretching or straightening your penis, or if you have pain or other concerns.
Croatian: Odmah se obratite svom liječniku ako imate poteškoća s istezanjem ili ispravljanjem penisa ili ako
English: • a popping sound or sensation in an erect penis
Croatian: • pucketajući zvuk ili osjećaj u penisu u erekciji
English: Use caution with cords as they approach the PIP flexion crease area.
Croatian: Budite oprezni s tračcima u blizini fleksijske brazde PIP zgloba.
English: • bruising or swelling of the penis and pain in the penis
Croatian: • modrice ili oticanje penisa i bol u penisu
English: Peyronie's disease
Croatian: Peyronijevom bolešću.
English: After reconstitution, immediate use of the medicine is recommended.
Croatian: Preporučuje se primijeniti lijek odmah nakon rekonstitucije.
English: • penis disorder
Croatian: • poremećaj penisa
English: Using a new sterile, hubless syringe with 0.01 ml graduations and a permanently fixed, 26 or 27 gauge, 12 or 13 mm needle (not supplied), withdraw the adequate volume of reconstituted solution for a 0.58 mg dose of Xiapex required for injection to deliver:
Croatian: Pomoću nove sterilne štrcaljke bez mrtvog volumena s oznakama na svakih 0,01 ml i fiksirane igle od 26 ili 27 gaugea, duljine 12 ili 13 mm (nije priložena), izvucite odgovarajući volumen rekonstituirane otopine za dozu Xiapexa od 0,58 mg potrebnu za injekciju kako biste dali:
English: • collection of blood outside of a blood vessel on scrotum
Croatian: • nakupljanje krvi izvan krvne žile na mošnji
English: In the Dupuytren's contracture clinical trials at 30 days post the first injection, 92% of patients had circulating antibodies detected against AUX-I and 86% of patients against AUX-II.
Croatian: U kliničkim ispitivanjima u Dupuytrenovoj kontrakturi trideset dana nakon prve injekcije, u 92% bolesnika otkrivena su cirkulirajuća protutijela na AUX-I, a u 86% bolesnika na AUX-II.
English: If the cord has not disrupted after 3 attempts of extension per cord, a follow-up visit may be scheduled approximately 4 weeks after the injection.
Croatian: Ako tračak nije popustio nakon 3 pokušaja ekstenzije po tračku, može se dogovoriti kontrolni posjet približno 4 tjedna nakon injekcije.
English: Different Fingers, 1 MP, 1 PIP (n=58)
Croatian: 1 MP, 1 PIP (n=58)
English: Most of the side effects that occurred in the clinical studies were mild or moderate in severity and most resolved within 2 weeks of the injection.
Croatian: Većina nuspojava koje su se pojavile u kliničkim ispitivanjima bile su blage ili umjerene težine i većinom su se povukle unutar 2 tjedna od injekcije.
English: Class I cleaves insoluble triple helical collagen with higher affinity than Class II collagenase.
Croatian: Skupina I ima veći afinitet prema cijepanju netopljivog trostrukog heliksa kolagena nego kolagenaze skupine II.
English: Use only the supplied diluent for reconstitution.
Croatian: Upotrijebite samo priloženo otapalo za rekonstituciju.
English: • dizziness, headache, nausea
Croatian: • omaglica, glavobolja, mučnina
English: The administration of two concurrent Xiapex injections into Dupuytren's cords in the same hand was evaluated in clinical study AUX-CC-867, a historically-controlled, open-label multi-centre trial in 715 adult subjects (1450 Xiapex injections) with Dupuytren's contracture.
Croatian: Istovremena primjena dvije injekcije Xiapexa u Dupuytrenove tračke na istoj šaci bila je procijenjena u kliničkom ispitivanju AUX-CC-867, multicentričnom ispitivanju otvorenog tipa s kontrolnom skupinom iz prošlosti, koje je provedeno u 715 odraslih ispitanika (1450 injekcija Xiapexa) s Dupuytrenovom kontrakturom.
English: Local anaesthesia may be used, if needed, during the finger extension procedure.
Croatian: Tijekom postupka ekstenzije prsta, ako je potrebno, može se primijeniti lokalna anestezija.
English: • rash, eczema
Croatian: • osip, ekcem
English: Symptoms of penile fracture (corporal rupture) or other serious injury to your penis may include:
Croatian: Simptomi prijeloma penisa (rupture korpusa) ili drugih ozbiljnih ozljeda penisa mogu uključivati:
English: What you need to know before you are given Xiapex You must not be given Xiapex:
Croatian: Što morate znati prije nego primite Xiapex
English: N (%) of Recurrent Joints in Each Intervalb
Croatian: N (%) zglobova s recidivom u pojedinom razdobljub
English: While the patient's wrist is in the flexed position, apply moderate stretching pressure to the injected cord by extending the finger for approximately 10 to 20 seconds.
Croatian: Dok je zapešće bolesnika u fleksiji treba primijeniti umjeren istežući pritisak na injicirani tračak ekstenzijom prsta tijekom približno 10 do 20 sekundi.
English: If refrigerated, the reconstituted solution must be allowed to return to ambient room temperature (20ºC-25ºC) for approximately 15 minutes before use.
Croatian: Ako je bila u hladnjaku, rekonstituirana otopina mora se ostaviti da postigne sobnu temperaturu (20ºC-25ºC) približno 15 minuta prije primjene.
English: • skin wound at the site of injection
Croatian: • rana koja zahvaća kožu na mjestu injekcije
English: Calcium chloride dihydrate Sodium chloride Water for injections
Croatian: Otapalo kalcijev klorid dihidrat natrijev klorid voda za injekcije
English: At five years after the initial injection of Xiapex, 92.8% and 93.4% of subjects were seropositive for anti-AUX-I and anti-AUX-II respectively.
Croatian: Pet godina nakon prve injekcije Xiapexa 92,8% ispitanika bilo je seropozitivno na anti-AUX-I, a 93,4% na anti-AUX-II protutijela.
English: • thickening near ligament at base of penis
Croatian: • zadebljanje blizu ligamenta kod korijena penisa
English: Wearing gloves the physician should grasp the plaque or indurated portion of the flaccid penis about 1 cm proximal and distal to the injection site.
Croatian: Pri postupku liječnik treba nositi rukavice i uhvatiti plak ili indurirani dio opuštenog penisa otprilike 1 cm proksimalno i distalno od mjesta injiciranja.
English: Metabolism and nutrition disorders
Croatian: Poremećaji metabolizma i prehrane zadržavanje tekućine
English: Because Xiapex lyses collagen, care must be taken to avoid injecting into tendons, nerves, blood vessels, or other collagen-containing structures of the hand.
Croatian: Budući da Xiapex razgrađuje kolagen, mora se paziti da se lijek ne injicira u tetive, živce, krvne žile ili druge strukture na šaci koje sadrže kolagen.
English: Injection of Xiapex into a Peyronie's plaque, which is comprised mostly of collagen, may result in enzymatic disruption of the plaque.
Croatian: Peyronijev plak koji je većinom građen od kolagena može dovesti do enzimatske razgradnje plaka.
English: • feeling of pain in the groin, shoulder, chest wall, or neck
Croatian: • osjećaj bola u preponama, ramenu, stijenci prsnog koša ili vratu
English: Most of the side effects that occurred in the clinical studies were mild or moderate in severity and were localised to the hand treated.
Croatian: Većina nuspojava koje su nastale u kliničkim ispitivanjima bile su blage do umjerene težine i lokalizirane na liječenu šaku.
English: How to store Xiapex
Croatian: Kako čuvati Xiapex
English: • stiffness, creaking of the joints
Croatian: • ukočenost, škripanje zglobova
English: Xiapex is injected by your doctor into the cord in your finger/hand or plaque in your penis and works by breaking down the collagen in the cord or plaque.
Croatian: Liječnik u tračak u Vašem prstu/ruci ili u plak u Vašem penisu ubrizgava Xiapex, koji djeluje tako što razgrađuje kolagen u tračku ili plaku.
English: N (%) of Joints in Each Intervala
Croatian: N (%) zglobova u pojedinom razdobljua
English: A significant mean improvement (74.4%) from baseline to Day 31 was observed overall in fixed flexion contracture following administration of two concurrent injections of Xiapex 0.58 mg (one injection per joint) in the same hand, see Table 6.
Croatian: Uglavnom je bilo opaženo značajno prosječno poboljšanje (74,4%) fiksne fleksijske kontrakture od početnog stanja do 31. dana nakon istovremene primjene dvije injekcije Xiapexa u dozi od 0,58 mg (jedna injekcija po zglobu) u istu šaku; vidjeti tablicu 6.
English: Adverse reactions reported from the clinical programme are those that occurred in the Phase 3 double-blind placebo-controlled studies.
Croatian: Nuspojave zabilježene u kliničkom programu su one koje su se javile u dvostruko slijepim, placebom kontroliranim ispitivanjima faze III.
English: The recommended dose of Xiapex is 0.58 mg per injection into a palpable Dupuytren's cord.
Croatian: Preporučena doza Xiapexa je 0,58 mg po injekciji u opipljiv Dupuytrenov tračak.
English: Local anaesthesia may be applied before the modelling if desired.
Croatian: Po želji se prije modeliranja može primijeniti lokalna anestezija.
English: • To elevate the injected hand as much as possible until the day after the finger extension procedure.
Croatian: • injiciranu šaku drže podignutu što je više moguće do dana nakon postupka ekstenzije prsta.
English: Pack of 1 vial of powder and 1 vial of solvent
Croatian: Pakiranje od 1 bočice praška i 1 bočice otapala
English: • fast heart rate
Croatian: • ubrzani otkucaji srca
English: • reactions at the injection site like bleeding, pain, swelling, tenderness and bruising
Croatian: • reakcije na mjestu injekcije poput krvarenja, bola, otečenosti, osjetljivosti i modrice
English: • skin disorder/irritation
Croatian: • poremećaj/iritacija kože
English: Table 1 presents adverse reactions listed by system organ class and frequency categories, using the following convention: very common (≥1/10), common (≥1/100 to <1/10), and uncommon (≥1/1,000 to <1/100), and not known: cannot be estimated from the available data.
Croatian: Tablica 1 prikazuje nuspojave prema klasifikaciji organskih sustava i kategorijama učestalosti sukladno sljedećoj konvenciji: vrlo često (≥1/10), često (≥1/100 i <1/10) i manje često (≥1/1000 i
English: Table 1: Tabulated list of adverse reactions.
Croatian: Tablica 1: Tablični popis nuspojava.
English: Solvent for Xiapex
Croatian: Otapalo za Xiapex
English: An anaphylactic reaction was reported in a post-marketing clinical study in a patient who had previous exposure to Xiapex for the treatment of Dupuytren's contracture, demonstrating that severe reactions including anaphylaxis can occur following Xiapex injections.
Croatian: U kliničkom ispitivanju nakon stavljanja lijeka u promet zabilježena je anafilaktička reakcija u bolesnika koji je prethodno već bio izložen Xiapexu zbog liječenja Dupuytrenove kontrakture, što pokazuje da može doći do pojave teških reakcija uključujući anafilaksiju nakon injekcija Xiapexa.
English: Disorientation Agitation Insomnia Irritability Restlessness
Croatian: Psihijatrijski poremećaji dezorijentacija agitiranost nesanica razdražljivost nemir
English: For Xiapex no clinical data on exposed pregnancies are available.
Croatian: Nema dostupnih kliničkih podataka o izlaganju trudnica Xiapexu.
English: There were no other clinically relevant differences between two concurrent injections of Xiapex in the same hand and up to three single injections of Xiapex in the types of adverse events reported (i.e., most adverse events were local to the treated extremity and of mild or moderate intensity).
Croatian: Xiapexa istovremeno u istu šaku i do tri jednokratne injekcije Xiapexa (tj. većina štetnih događaja bila je lokalna na liječenom ekstremitetu te blagog do umjerenog intenziteta).
English: In the three double-blind, placebo-controlled phase 3 studies in Dupuytren's contracture, 73% of Xiapex-treated patients reported an ecchymosis or a contusion and 38% reported a haemorrhage at the injection site.
Croatian: U tri dvostruko slijepa, placebom kontrolirana ispitivanja faze III u Dupuytrenovoj kontrakturi, u 73% bolesnika liječenih Xiapexom zabilježene su ekhimoze ili kontuzija, a u 38% krvarenje na mjestu injekcije.
English: Hydrochloric acid 2.4% w/w (for pH adjustment)
Croatian: Prašak saharoza trometamol kloridna kiselina 2,4% m/m (za podešavanje pH)
English: Administration of a local anaesthetic medicinal product prior to injection of Xiapex is not recommended, as it may interfere with proper placement of the injection.
Croatian: Ne preporučuje se primjena lokalnog anestetika prije injekcije Xiapexa, jer može omesti davanje injekcije na pravo mjesto.
English: • reactions at the injection site such as presence of a blister, swelling, itching or a solid raised area under the skin
Croatian: • reakcije na mjestu injekcije poput mjehura, oticanja, svrbeža ili čvrstog uzdignutog područja pod kožom
English: As an exploratory analysis, female sexual partners completed two questionnaires at both the screening visit and week 36: the PDQ for Female Sexual Partners (an adaptation of Peyronie's disease bother and psychological symptom domains of the PDQ for men, scoring from 0-12) and the Female Sexual Function Index (FSFI, scale from 2-36, where a higher score represents better sexual functioning).
Croatian: Peyronijeve bolesti upitnika PDQ za muškarce, s rasponom bodova od 0 do 12) i Indeks ženske spolne funkcije (engl., Female Sexual Function Index - FSFI, ljestvica od 2 do 36, gdje veći broj bodova predstavlja bolje seksualno funkcioniranje).
English: PIP Jointsb p-value
Croatian: PIP zglobovib p-vrijednost
English: Receiving an injection of Xiapex may cause damage to the tubes in your penis called the corpora.
Croatian: Ubrizgavanje Xiapexa može oštetiti cilindrične dijelove penisa koji se nazivaju tijela.
English: In addition, patients were instructed to perform penile modelling at home for six weeks after each treatment cycle.
Croatian: Bolesnicima su dodatno date upute kako da provode modeliranje penisa kod kuće tijekom 6 tjedana nakon svakog ciklusa liječenja.
English: Manufacturer Swedish Orphan Biovitrum AB (publ), SE-112 76 Stockholm, Sweden
Croatian: Swedish Orphan Biovitrum AB (publ), SE-112 76 Stockholm, Švedska
English: Clinical study experience with Xiapex is currently limited to up to 3 injections per cord and up to a total of 8 injections in the hands.
Croatian: Iskustvo s Xiapexom u kliničkim ispitivanjima trenutno je ograničeno na najviše 3 injekcije po tračku i ukupno 8 injekcija u šake.
English: Baseline Mean Mean Change a Treatment Difference (95% CI)
Croatian: Razlika između liječenja (95% CI)
English: • For cords affecting PIP joints, each dose is administered in an injection volume of 0.20 ml.
Croatian: • u tračke koji zahvaćaju MP zglobove svaka doza se primjenjuje u volumenu injekcije od 0,25 ml • u tračke koji zahvaćaju PIP zglobove svaka doza se primjenjuje u volumenu injekcije od 0,20 ml
English: These collagenases, referred to as AUX-I and AUX-II, are representative of the two major collagenase classes (Class I and
Croatian: Ove kolagenaze, koje se zovu AUX-I i AUX-II, predstavnici su dvije glavne skupine kolagenaza (skupina I i skupina II) koje proizvodi Clostridium histolyticum.
English: Gender, n (%) Male Female Family history of Dupuytren's disease, n
Croatian: Dupuytrenova bolest u obiteljskoj anamnezi n (%)
English: Xiapex 0.9 mg powder and solvent for solution for injection
Croatian: Xiapex 0,9 mg prašak i otapalo za otopinu za injekciju
English: The efficacy of Xiapex was evaluated in two randomized, double-blind, placebo-controlled studies, Study 1 (AUX-CC-803) and Study 2 (AUX-CC-804), in adult males with Peyronie's disease.
Croatian: Djelotvornost Xiapexa procijenjena je u dva randomizirana, dvostruko slijepa, placebom kontrolirana ispitivanja, Ispitivanju 1 (AUX-CC-803) i Ispitivanju 2 (AUX-CC-804), u odraslih muškaraca s
English: • Administer suitable local anaesthetic, if desired.
Croatian: • Po želji primijenite odgovarajući lokalni anestetik.
English: • To return to see their physician approximately 24-72 hours after each injection for an examination of the injected hand and a possible finger extension procedure to disrupt the cord.
Croatian: • Da se vrate i posjete liječnika približno 24-72 sata nakon svake injekcije zbog pregleda šake nakon injekcije i mogućeg postupka ekstenzije prsta zbog razbijanja tračka.
English: Injection of Xiapex into collagen-containing structures such as the corpora cavernosa of the penis may result in damage to those structures and possible injury such as corporal rupture (penile fracture).
Croatian: Ruptura korpusa (fraktura penisa) ili druge ozbiljne ozljede penisa u liječenju Peyronijeve bolesti Injekcija Xiapexa u strukture koje sadrže kolagen kao što su kavernozna tijela penisa može dovesti do oštećenja tih struktura i moguće ozljede kao što je ruptura korpusa (fraktura penisa).
English: For cords affecting the PIP joint, the finger extension procedure should be performed when the MP joint is in the flexed position.
Croatian: Za tračke koji zahvaćaju PIP zglob postupak ekstenzije prsta treba izvršiti dok je MP zglob u fleksiji.
English: Within each frequency group, adverse reactions are presented in order of decreasing seriousness.
Croatian: nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
English: Long Term Recurrence Rates for Joints Treated Successfully with XIAPEX
Croatian: Stope recidiva kontraktura u dugoročnom praćenju za zglobove uspješno liječene XIAPEXOM
English: A. MANUFACTURER(S) OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Croatian: PROIZVOĐAČ(I) BIOLOŠKE DJELATNE TVARI I PROIZVOĐAČ(I)
English: Mean Change in Peyronie's Disease Bother Domain Score from Baseline to Week 52 - Studies 1 and 2
Croatian: Srednja promjena broja bodova u dijelu "tegobe" upitnika za Peyronijevu bolest od početka ispitivanja do 52. tjedna - Ispitivanja 1 i 2
English: The patient should then be instructed to self-perform penile modelling activities at home each day for the 6-week period following the physician penile plaque modelling visit of each treatment cycle, according to the detailed instructions provided in the package leaflet.
Croatian: Bolesnicima treba dati upute za samostalno svakodnevno izvođenje tehnika modeliranja penisa kod kuće, i to u razdoblju od 6 tjedana nakon posjeta na kojem je liječnik napravio postupak modeliranja plaka penisa u svakom ciklusu liječenja, prema detajnim uputama navedenima u uputi o lijeku.
English: c Includes: injection site pain, penile pain, and injection site discomfort.
Croatian: c Uključuje: bol na mjestu injekcije, bol u penisu i nelagodu na mjestu injekcije.
English: Place the needle tip on the side of the target plaque in alignment with the point of maximal concavity.
Croatian: Namjestite vrh igle sa strane ciljnog plaka usmjeren prema točki najjače udubljenosti.
English: b A recurrent joint was a joint evaluated by the investigator as having a worsening Dupuytren's contracture due to a palpable cord.
Croatian: b Kao zglob s recidivom je označen zglob koji je ispitivač ocijenio kao onaj kod kojeg je došlo do pogoršanja Dupuytrenove kontrakture zbog nastanka opipljivog tračka.