FrancophonIA/ELRC3.0 huggingface dataset:
English: Paediatric population: The recommended dose of Emtriva for children aged 4 months and over and adolescents up to 18 years of age weighing at least 33 kg who are able to swallow hard capsules is one 200 mg hard capsule, taken orally, once daily.
Danish: Pædiatrisk population: Den anbefalede dosis af Emtriva til børn på 4 måneder og derover samt unge op til 18 år, som vejer mindst 33 kg og som kan synke hårde kapsler, er én 200 mg hård kapsel, taget oralt, en gang dagligt.
English: Hepatic insufficiency: No data are available on which to make a dose recommendation for patients with hepatic insufficiency.
Danish: Leverinsufficiens: Der foreligger ingen data, hvorpå der kan laves en dosisanbefaling til patienter med leverinsufficiens.
English: You should not take Emtriva if you are already taking other medicines that contain emtricitabine or lamivudine, which are also used to treat HIV infection, unless otherwise directed by your doctor.
Danish: De må ikke tage Emtriva, hvis De allerede tager anden medicin, som indeholder emtricitabin eller lamivudin, som også anvendes til at behandle hiv-infektion, medmindre Deres læge foreskriver dette.
English: 2 Anaemia was common and skin discolouration (increased pigmentation) was very common when emtricitabine was administered to paediatric patients (see section 4.8, Paediatric population).
Danish: 2 Anæmi var almindelig og misfarvning af huden (forøget pigmentering) var meget almindelig, når emtricitabin blev administreret til pædiatriske patienter (se pkt.
English: In addition to the adverse reactions reported in adults, anaemia (9.5%) and skin discolouration (31.8%) occurred more frequently in clinical trials involving HIV infected paediatric patients.
Danish: Ud over bivirkninger rapporteret hos voksne forekom anæmi (9,5%) og misfarvning af huden (31,8%) hyppigere i kliniske studier med hiv-inficerede pædiatriske patienter.
English: Emtricitabine is not recommended as monotherapy for the treatment of HIV infection.
Danish: Emtricitabin anbefales ikke som monoterapi til behandling af hiv-infektion.
English: Sodium phosphate monobasic hydrate Sunset yellow (E110) Purified water
Danish: Monobasisk natriumphosphathydrat Sunset yellow FCF (E110) Renset vand
English: How to take Emtriva • Always take this medicine exactly as your doctor has told you.
Danish: Sådan skal De tage Emtriva • Tag altid lægemidlet nøjagtigt efter lægens anvisning.
English: If a patient misses a dose of Emtriva within 12 hours of the time it is usually taken, the patient should take Emtriva with or without food as soon as possible and resume their normal dosing schedule.
Danish: Hvis en patient glemmer at tage en dosis Emtriva i mindre end 12 timer efter tidspunktet, hvor patienten normalt tager dosen, skal patienten tage Emtriva med eller uden mad så snart som muligt og derefter fortsætte med den normale doseringsplan.
English: If a patient misses a dose of Emtriva by more than 12 hours and it is almost time for their next dose, the patient should not take the missed dose and simply resume the usual dosing schedule.
Danish: Hvis en patient glemmer at tage en dosis Emtriva i mere end 12 timer, og det næsten er tid til næste dosis, skal patienten ikke tage den manglende dosis, men blot fortsætte med den normale doseringsplan.
English: Assessment of adverse reactions in paediatric patients from clinical study data is based on experience in three paediatric studies (n = 169) where treatment-naïve (n = 123) and treatment-experienced (n = 46) paediatric HIV infected patients aged 4 months to 18 years were treated with emtricitabine in combination with other antiretroviral agents.
Danish: Vurderingen af bivirkningsdata fra kliniske studier med pædiatriske patienter er baseret på erfaringer fra tre pædiatriske studier (n = 169), hvor behandlingsnaive (n = 123) og behandlingserfarne (n = 46) hiv-inficerede pædiatriske patienter i alderen fra 4 måneder til 18 år fik behandling med emtricitabin i kombination med andre antiretrovirale midler.
English: Patients with liver disease including chronic hepatitis B or C, who are treated with antiretrovirals, have a higher risk of severe and potentially fatal liver complications.
Danish: Patienter med leversygdom, inklusive kronisk hepatitis B eller C, som behandles med antiretrovirale midler, har en forhøjet risiko for alvorlige og potentielt livstruende bivirkninger i leveren.
English: Magnesium stearate (E572) Microcrystalline cellulose (E460) Povidone (E1201)
Danish: Magnesiumstearat (E572) Mikrokrystallinsk cellulose (E460) Povidon (E1201)
English: Package leaflet: Information for the user Emtriva 200 mg hard capsules
Danish: Indlægsseddel: Information til brugeren Emtriva 200 mg hårde kapsler
English: Antiviral activity in vitro: The 50% inhibitory concentration (IC50) value for emtricitabine against laboratory and clinical isolates of HIV-1 was in the range of 0.0013 to 0.5 µmol/l.
Danish: Antiviral aktivitet in vitro: Den koncentration af emtricitabin, som er nødvendig for 50% hæmning (IC50) af laboratoriemæssige og kliniske isolater af hiv 1, lå inden for området 0,0013-0,5 µmol/l.
English: Please refer to the package leaflets of the other antiretrovirals for guidance on how to take those medicines.
Danish: De bedes venligst læse indlægssedlerne til de andre slags antiretroviral medicin som vejledning i at indtage medicinen korrekt.
English: Co-administration of emtricitabine with medicinal products that are eliminated by active tubular secretion may lead to an increase in serum concentrations of either emtricitabine or a co-administered medicinal product due to competition for this elimination pathway.
Danish: Samtidig administration af emtricitabin og lægemidler, som elimineres ved aktiv tubulær sekretion, kan føre til en stigning i serumkoncentrationer af enten emtricitabin eller et samtidig administreret lægemiddel på grund af konkurrencen om denne eliminationsvej.
English: • The active substance is emtricitabine.
Danish: • Aktivt stof: emtricitabin.
English: In general, emtricitabine pharmacokinetics in HBV infected subjects were similar to those in healthy subjects and in HIV infected subjects.
Danish: Generelt lignede emtricitabins farmakokinetik hos HBV-inficerede forsøgspersoner den hos raske forsøgspersoner og hos hiv-inficerede forsøgspersoner.
English: • headache, diarrhoea, feeling sick (nausea)
Danish: • hovedpine, diarré, kvalme
English: The mean AUC in 77 infants, children and adolescents receiving 6 mg/kg emtricitabine once daily as oral solution or 200 mg emtricitabine as hard capsules once daily was similar to the mean AUC of 10.0 µg·h/mL in 20 adults receiving 200 mg hard capsules once daily.
Danish: Det gennemsnitlige AUC hos 77 børn og unge, som fik 6 mg/kg emtricitabin en gang daglig som oral opløsning eller 200 mg emtricitabin som hårde kapsler en gang daglig, kunne sammenlignes med det gennemsnitlige AUC på 10,0 µg·t/ml hos 20 voksne, som fik 200 mg hårde kapsler en gang daglig.
English: If you accidentally take too much Emtriva oral solution, contact your doctor or nearest emergency department for advice.
Danish: Hvis De ved et uheld tager for meget Emtriva som oral opløsning, skal De kontakte lægen eller den nærmeste skadestue for at få råd.
English: Patients with renal impairment: Emtricitabine is eliminated by renal excretion and exposure to emtricitabine was significantly increased in patients with renal insufficiency.
Danish: Patienter med nedsat nyrefunktion: Emtricitabin elimineres ved renal udskillelse, og eksponeringen for emtricitabin steg signifikant hos patienter med nyreinsufficiens.
English: • The other ingredients are: cotton candy flavouring, disodium edetate, hydrochloric acid, methyl parahydroxybenzoate (E218), propylene glycol, propyl parahydroxybenzoate (E216), sodium hydroxide, sodium phosphate monobasic hydrate, sunset yellow (E110), purified water, xylitol (E967).
Danish: • Øvrige indholdsstoffer: sukkervataroma, dinatriumedetat, saltsyre, methylparahydroxybenzoat (E218), propylenglycol, propylparahydroxybenzoat (E216), natriumhydroxid, monobasisk natriumphosphathydrat, sunset yellow FCF (E110), renset vand, xylitol (E967).
English: Recommended dose of Emtriva 10 mg/mL oral solution every 24 hours
Danish: Anbefalet dosis af Emtriva 10 mg/ml oral opløsning hver 24. time
English: The systemic emtricitabine exposure (mean ± standard deviation) increased from 11.8 ± 2.9 µg·h/mL in subjects with normal renal function to 19.9 ± 1.1, 25.0 ± 5.7 and 34.0 ± 2.1 µg·h/mL, in patients with mild, moderate and severe renal impairment, respectively.
Danish: Den systemiske emtricitabineksponering (gennemsnit ± standardafvigelsen) steg fra 11,8 ±2,9 µg·t/ml hos forsøgspersoner med normal nyrefunktion til 19,9 ±1,1, 25,0 ± 5,7 og 34,0 ± 2,1 µg·t/ml hos patienter med henholdsvis mildt, moderat og svært nedsat nyrefunktion.
English: Caution should be exercised when emtricitabine is co-administered with medicinal products that are eliminated by active tubular secretion as such co-administration may lead to an increase in serum concentrations of either emtricitabine or a co-administered medicinal product, due to competition for this elimination pathway (see section 4.5).
Danish: Der skal udvises forsigtighed, når emtricitabin gives samtidig med lægemidler, som elimineres ved aktiv tubulær sekretion, da sådan samtidig administration kan føre til en stigning i serumkoncentrationer af enten emtricitabin eller et samtidig administreret lægemiddel på grund af konkurrencen om denne eliminationsvej (se pkt.
English: The cup has lines to indicate each mL of solution.
Danish: Bægeret har streger, der angiver hver 1 ml opløsning.
English: Elderly patients are more likely to have decreased renal function; therefore caution should be exercised when treating elderly patients with Emtriva.
Danish: Da det er mere sandsynligt, at ældre patienter har nedsat nyrefunktion, skal der udvises forsigtighed ved behandling af ældre patienter med Emtriva.
English: Capsule contents: microcrystalline cellulose (E460), crospovidone, magnesium stearate (E572), povidone (E1201)
Danish: Kapslen indeholder: mikrokrystallinsk cellulose (E460), crospovidon, magnesiumstearat (E572), povidon (E1201)
English: Each dose (24 mL) contains 36 mg methyl parahydroxybenzoate (E218), 3.6 mg propyl parahydroxybenzoate (E216), 1.2 mg sunset yellow (E110), 480 mg propylene glycol and has a sodium content of 36 mg.
Danish: Hjælpestof(fer), som behandleren skal være opmærksom på Hver dosis (24 ml) indeholder 36 mg methylparahydroxybenzoat (E218), 3,6 mg propylparahydroxybenzoat (E216), 1,2 mg sunset yellow FCF (E110), 480 mg propylenglycol og har et natriumindhold på 36 mg.
English: Patients with chronic hepatitis B or C infection treated with CART are at increased risk of experiencing severe, and potentially fatal, hepatic adverse events.
Danish: Hos patienter med kronisk hepatitis B eller C, som behandles med CART, er der en øget risiko for svære og potentielt letale, hepatiske uønskede hændelser.
English: If the patient vomits within 1 hour of taking Emtriva, another dose should be taken.
Danish: Hvis patienten kaster op inden for 1 time efter at have taget Emtriva, skal der tages en ny dosis.
English: Metabolism and nutrition disorders: Common:
Danish: allergiske reaktioner Metabolisme og ernæring: Almindelig:
English: Emtriva 200 mg hard capsules may be taken with or without food.
Danish: Dosering Emtriva 200 mg hårde kapsler kan tages med eller uden mad.
English: Therefore, clinical response to treatment and renal function should be closely monitored in these patients (see section 4.4).
Danish: Derfor bør det kliniske respons på behandlingen og nyrefunktionen monitoreres tæt hos disse patienter (se pkt.
English: Package leaflet: Information for the user Emtriva 10 mg/mL oral solution
Danish: Indlægsseddel: Information til brugeren Emtriva 10 mg/ml oral opløsning
English: elevated amylase including elevated pancreatic amylase, elevated serum lipase, vomiting, abdominal pain, dyspepsia Hepatobiliary disorders: Common:
Danish: forhøjet amylase, herunder forhøjet pancreasamylase, forhøjet serum-lipase, opkastning, abdominalsmerter, dyspepsi
English: Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) which works by interfering with the normal working of an enzyme (reverse transcriptase) that is essential for the HIV virus to reproduce itself.
Danish: De virker ved at gribe ind i den normale måde, som et enzym (reverse transkriptase) arbejder på, og som er nødvendigt for at virus kan reproducere sig selv.
English: If Emtriva is discontinued in patients co-infected with HIV and hepatitis B virus (HBV), these patients should be closely monitored for evidence of exacerbation of hepatitis (see section 4.4).
Danish: Hvis Emtriva seponeres hos patienter, der samtidig er inficeret med hiv og hepatitis B-virus (HBV), skal disse patienter monitoreres tæt for tegn på eksacerbation af hepatitis (se pkt.
English: Therefore, children who weigh at least 33 kg may take either one 200 mg hard capsule daily or the oral solution up to a maximum dose of 240 mg (24 mL), once daily.
Danish: Derfor kan børn, som vejer mindst 33 kg, enten tage én 200 mg hård kapsel daglig eller den orale opløsning op til en maksimal dosis af 240 mg (24 ml), en gang daglig.
English: Paediatric population: The recommended dose of Emtriva 10 mg/mL oral solution is 6 mg/kg up to a maximum of 240 mg (24 mL) once daily.
Danish: Pædiatrisk population: Den anbefalede dosis af Emtriva 10 mg/ml oral opløsning er 6 mg/kg op til maksimalt 240 mg (24 ml) en gang dagligt.
English: Table 1: Dose interval guidelines for 200 mg hard capsules adjusted according to creatinine clearance
Danish: Tabel 1: Retningslinjer for dosisinterval for 200 mg hårde kapsler, justeret i forhold til kreatininclearance
English: Emtriva 10 mg/mL oral solution may be taken with or without food.
Danish: Emtriva 10 mg/ml oral opløsning kan tages med eller uden mad.
English: Printing ink containing Black iron oxide (E172) Shellac (E904)
Danish: Trykfarven indeholder Sort jernoxid (E172) Shellac (E904)
English: Immune system disorders: Common:
Danish: Immunsystemet: Almindelig:
English: There is insufficient information on the effects of emtricitabine in newborns/infants.
Danish: Der foreligger utilstrækkelige data for virkningen af emtricitabin på det ammede barn.
English: Emtriva 10 mg/mL oral solution should be taken once daily, orally with or without food.
Danish: Emtriva 10 mg/ml oral opløsning skal tages en gang dagligt oralt, med eller uden mad.
English: You do not need to take another dose if you were sick more than an hour after taking Emtriva.
Danish: De behøver ikke tage en ny dosis, hvis De kaster op mere end en time efter, De har taget Emtriva.
English: Children aged 4 months and over, who weigh at least 33 kg may either take one 200 mg hard capsule daily or may take emtricitabine as the oral solution up to a maximum of 240 mg once daily.
Danish: Børn på 4 måneder og derover, som vejer mindst 33 kg, kan enten tage én 200 mg hård kapsel dagligt, eller kan tage emtricitabin som oral opløsning op til maksimalt 240 mg en gang dagligt.
English: Pack size: 30 hard capsules.
Danish: Pakningsstørrelse: 30 hårde kapsler.
English: In addition to the adverse reactions experienced by adults, anaemia and skin discolouration occurred more frequently in clinical trials involving HIV infected paediatric patients (see section 4.8).
Danish: Ud over de bivirkninger, som voksne oplevede, forekom anæmi og misfarvning af huden hyppigere i kliniske studier med hiv-inficerede pædiatriske patienter (se pkt.
English: Method of administration Emtriva 200 mg hard capsules should be taken once daily, orally with or without food.
Danish: Administration Emtriva 200 mg hårde kapsler skal tages en gang dagligt, oralt, med eller uden mad.
English: In some patients with advanced liver disease or cirrhosis, stopping treatment is not recommended as this may lead to worsening of hepatitis.
Danish: Hos patienter med fremskreden leversygdom eller levercirrose bør behandlingen ikke ophøre, da det hos nogle patienter kan medføre forværring af hepatitis.
English: Adults: The recommended dose of Emtriva 10 mg/mL oral solution is 240 mg (24 mL) once daily.
Danish: Voksne: Den anbefalede dosis af Emtriva 10 mg/ml oral opløsning er 240 mg (24 ml) en gang daglig.
English: Table 1 below provides dose interval adjustment guidelines for the 200 mg hard capsules according to the degree of renal insufficiency.
Danish: Tabel 1 nedenfor giver retningslinjer for justering af dosisintervallet for 200 mg hårde kapsler i henhold til graden af nyreinsufficiens.
English: This is to make sure that your medicine is fully effective, and to reduce the risk of developing resistance to the treatment.
Danish: • Tag altid den dosis, Deres læge har anbefalet for at sikre, at medicinen er fuldt ud effektiv og for at reducere udviklingen af resistens mod behandlingen.
English: One 200 mg hard capsule every 96 hours
Danish: Én 200 mg hård kapsel hver 96. time
English: Viruses resistant to zidovudine, didanosine and NNRTIs retained their sensitivity to emtricitabine (IC50= 0.002 µmol/l to 0.08 µmol/l).
Danish: Virus, som var resistente over for zidovudin, didanosin og NNRTIs, beholdt deres følsomhed over for emtricitabin (IC50 = 0,002 µmol/l-0,08 µmol/l).
English: Viruses resistant to zidovudine, didanosine and NNRTIs retained their sensitivity to emtricitabine (IC50 = 0.002 µmol/l to 0.08 µmol/l).
Danish: Virus, som var resistente over for zidovudin, didanosin og NNRTIs, beholdt deres følsomhed over for emtricitabin (IC50= 0,002 µmol/l-0,08 µmol/l).
English: Propyl parahydroxybenzoate (E216) Sodium hydroxide
Danish: Propylparahydroxybenzoat (E216) Natriumhydroxid
English: Capsule shell: gelatin, indigotine (E132), titanium dioxide (E171) Printing ink containing: black iron oxide (E172), shellac (E904)
Danish: Kapslens skal: gelatine, indigotin (E132), titandioxid (E171) Trykfarven indeholder: sort jernoxid (E172), shellac (E904)
English: In vitro, emtricitabine did not inhibit metabolism mediated by any of the following human CYP450 isoforms: 1A2, 2A6, 2B6, 2C9, 2C19, 2D6 and 3A4.
Danish: In vitro hæmmede emtricitabin ikke metabolisme medieret af en af de følgende humane CYP450isoformer: 1A2, 2A6, 2B6, 2C9, 2C19, 2D6 og 3A4.
English: vesiculobullous rash, pustular rash, maculopapular rash, rash, pruritus, urticaria, skin discolouration (increased pigmentation)1,2
Danish: vesikulobulløst udslæt, pustuløst udslæt, makulopapuløst udslæt, udslæt, pruritus, urticaria, misfarvning af huden (forøget pigmentering)1,2
English: General disorders and administration site conditions: Common:
Danish: Almene symptomer og reaktioner på administrationssstedet: Almindelig:
English: How much 10 mg/mL solution to take (mL)
Danish: Hvilken mængde 10 mg/ml oral opløsning skal tages (ml)
English: If you do miss a dose of Emtriva within 12 hours of when it is usually taken, take it as soon as you can, and then take your next dose at its regular time.
Danish: Hvis De - inden for 12 timer efter, dosis normalt tages - kommer i tanker om, at De har glemt at tage en dosis, skal De tage den så hurtigt som muligt og derefter tage den næste dosis på det normale tidspunkt.
English: Table 1 below provides daily doses of Emtriva 10 mg/mL oral solution according to the degree of renal insufficiency.
Danish: Tabel 1 nedenfor giver daglige doser af Emtriva 10 mg/ml oral opløsning i henhold til graden af nyreinsufficiens.
English: The following side effects are uncommon (these can affect up to 1 in every 100 patients):
Danish: Følgende bivirkninger er ikke almindelige (de kan opstå hos op til 1 ud af 100 patienter):
English: Emtricitabine did not inhibit in vitro drug metabolism mediated by the following human CYP450 isoenzymes: 1A2, 2A6, 2B6, 2C9, 2C19, 2D6 and 3A4.
Danish: Emtricitabin hæmmede ikke in vitro lægemiddelmetabolisme medieret af følgende humane CYP450-isoenzymer: 1A2, 2A6, 2B6, 2C9, 2C19, 2D6 og 3A4.
English: Before starting treatment, your doctor may order blood tests to assess kidney function and may advise you to take a reduced dose of the oral solution or prescribe Emtriva hard capsules.
Danish: Før De påbegynder behandlingen, kan Deres læge tage blodprøver for at bedømme nyrefunktionen og råder Dem måske til at tage en reduceret dosis af den orale opløsning eller ordinerer Emtriva hårde kapsler til Dem. Deres læge kan også tage blodprøver under behandlingen for at overvåge Deres nyrer.
English: You do not need to take another capsule if you were sick more than an hour after taking Emtriva.
Danish: De behøver ikke tage en ny kapsel, hvis De kaster op mere end en time efter, De har taget Emtriva.
English: One mL of Emtriva oral solution contains 10 mg of emtricitabine (10 mg/mL).
Danish: Hver ml af Emtriva oral opløsning indeholder 10 mg emtricitabin (10 mg/ml).
English: What Emtriva is and what it is used for Emtriva is a treatment for Human Immunodeficiency Virus (HIV) infection in adults, children and infants aged 4 months and over.
Danish: Virkning og anvendelse Emtriva anvendes til behandling af human immundefekt virus (hiv) hos voksne og børn på
English: If the patient vomits more than 1 hour after taking Emtriva they do not need to take another dose.
Danish: Hvis patienten kaster op mere end 1 time efter at have taget Emtriva, skal patienten ikke tage en ny dosis.
English: Table 1: Daily doses of Emtriva 10 mg/mL oral solution adjusted according to creatinine clearance
Danish: Tabel 1: Daglige doser af Emtriva 10 mg/ml oral opløsning, justeret i forhold til kreatininclearance
English: • rashes (including red spots or blotches sometimes with blistering and swelling of the skin),
Danish: • udslæt (herunder røde pletter og skjolder undertiden med blærer eller hævelse af huden), som kan være allergiske reaktioner, kløe, ændringer i hudfarven, herunder pletvis mørkfarvning af huden
English: When tested for activity against laboratory strains of HBV, the IC50value for emtricitabine was in the range of 0.01 to 0.04 µmol/l.
Danish: Ved afprøvning for aktivitet mod laboratoriestammer af HBV lå emtricitabins IC50-værdi inden for området 0,01-0,04 µmol/l.
English: Each mL contains 10 mg of emtricitabine.
Danish: Hver ml indeholder 10 mg emtricitabin.
English: The following side effects are common (these can affect up to 10 in every 100 patients):
Danish: Følgende bivirkninger er almindelige (de kan opstå hos op til 10 ud af 100 patienter):
English: However, limited data are available on the efficacy and safety of emtricitabine (as a 200 mg hard capsule once daily) in patients who are co-infected with HIV and HBV.
Danish: Emtricitabin er aktiv in vitro mod HBV. Der foreligger imidlertid begrænsede data om virkningen og sikkerheden af emtricitabin (som en 200 mg hård kapsel én gang daglig) hos patienter, som samtidig er inficerede med hiv og HBV.
English: In patients with advanced liver disease or cirrhosis, treatment discontinuation is not recommended since post-treatment exacerbations of hepatitis may lead to hepatic decompensation.
Danish: Behandlingen bør ikke seponeres hos patienter med fremskreden leversygdom eller levercirrose, da hepatitis-eksacerbationer efter behandlingen kan føre til hepatisk dekompensation.
English: Elderly: Emtriva has not been studied in patients over the age of 65.
Danish: Ældre: Emtriva er ikke blevet undersøgt hos patienter over 65 år.
English: The methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216) may cause allergic reactions (possibly delayed).
Danish: Methylparahydroxybenzoat (E218) og propylparahydroxybenzoat (E216) kan give allergiske reaktioner (kan optræde efter behandlingen).
English: Recommended dose interval for 200 mg hard capsules
Danish: Anbefalet dosisinterval for 200 mg hårde kapsler
English: In addition to the adverse reactions reported in adults (see section 4.8, Tabulated summary of adverse reactions), the following adverse reactions were observed more frequently in paediatric patients: anaemia was common (9.5%) and skin discolouration (increased pigmentation) was very common (31.8%) in paediatric patients.
Danish: 4.8, Resumé af bivirkninger i tabelform) forekom følgende bivirkninger hyppigere hos pædiatriske patienter: anæmi var almindelig (9,5%), og misfarvning af huden (forøget pigmentering) var meget almindelig (31,8%) hos pædiatriske patienter.