FrancophonIA/ELRC3.0 huggingface dataset:
English: The frequencies for postmarketing reports were calculated from placebo-controlled clinical trials (comprising a total of 15,234 patients, 7,601 on raloxifene 60 mg and 7,633 on placebo) in postmenopausal women with osteoporosis, or established coronary heart disease (CHD) or increased risk for CHD, without comparison to the frequencies of adverse events in the placebo assignment groups.
Danish: Frekvenserne fra postmarketing-rapporter blev beregnet ud fra placebo-kontrollerede, kliniske studier (bestående af i alt 15.234 patienter, 7.601 på raloxifen 60 mg og 7.633 på placebo) hos postmenopausale kvinder med osteoporose, etableret koronar hjertesygdom (CHD) eller øget risiko for CHD, uden sammenligning med frekvenserne af bivirkningerne i placebogruppen.
English: Optruma contains lactose
Danish: Optruma indeholder lactose
English: In a study comparing Optruma with oestrogen, bone from patients treated with either medicinal product was histologically normal, with no evidence of mineralisation defects, woven bone or marrow fibrosis.
Danish: I en sammenlignende undersøgelse med Optruma overfor østrogen var patienternes knoglevæv under begge behandlinger histologisk normalt uden tegn på mineraliseringsdefekter, ikke-lamellær knogle (woven bone) eller knoglemarvsfibrose.
English: България ТП "Ели Лили Недерланд" Б.В.
Danish: ТП "Ели Лили Недерланд" Б.В.
English: Optruma contains lactose.
Danish: Optruma indeholder lactose.
English: Elliptically shaped, white tablets imprinted with the code '4165'.
Danish: Tabletterne er elliptiske, hvide og påtrykt koden 4165.
English: • Blood clot in an artery (for example stroke, including an increased risk of dying from stroke)
Danish: • Blodprop i en arterie (f.eks. slagtilfælde samt en øget risiko for at dø af et slagtilfælde) • Færre blodplader i blodet
English: Co-administration of raloxifene and warfarin does not alter the pharmacokinetics of either compound.
Danish: Samtidig administration af raloxifen og warfarin ændrer ikke disse lægemidlers farmakokinetik.
English: When a woman reaches the menopause, the level of the female sex hormone oestrogen goes down.
Danish: Når en kvinde kommer i overgangsalderen, falder produktionen af det kvindelige kønshormon, østrogen.
English: Other medicines and Optruma
Danish: Brug af anden medicin sammen med Optruma
English: This finding should be considered when prescribing raloxifene for postmenopausal women with a history of stroke or other significant stroke risk factors, such as transient ischemic attack or atrial fibrillation.
Danish: Dette skal tages i betragtning, når der ordineres raloxifen til postmenopausale kvinder, der tidligere har haft apopleksi eller har andre signifikante risikofaktorer for slagtilfælde, såsom transitorisk cerebral iskæmi eller atrieflimren.
English: Patients with this medical history should have serum triglycerides monitored when taking raloxifene.
Danish: Serumtriglycerid bør overvåges hos patienter med denne sygehistorie når de får raloxifen.
English: Across all placebo-controlled clinical trials of raloxifene in osteoporosis, venous thromboembolic events, including deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis occurred at a frequency of approximately 0.8 % or 3.22 cases per 1,000 patient years.
Danish: I alle placebokontrollerede kliniske studier med raloxifen mod osteoporose forekom venøse tromboemboliske tilfælde, inklusiv dyb venetrombose, lungeemboli og retinal venetrombose, med en frekvens på ca. 0,8 % eller 3,22 tilfælde pr. 1.000 patientår.
English: In female mice, an increased incidence of ovarian tumours in animals given 9 to 242 mg/kg (0.3 to 32 times the AUC in humans) included benign and malignant tumours of granulosa/theca cell origin and benign tumours of epithelial cell origin.
Danish: Hos hunmus, som fik 9 til 242 mg/kg (0,3 til 32 gange AUC hos mennesker), sås en øget forekomst af ovarietumorer, som inkluderede benigne og maligne tumorer af granulosa-/thecacelle oprindelse og benigne tumorer af epitelcelle oprindelse.
English: The influence of concomitant medication on raloxifene plasma concentrations was evaluated in the prevention and treatment trials.
Danish: Virkningen af samtidig medicin på raloxifen-plasmakoncentrationer blev evalueret i de kliniske studier til forebyggelse og behandling af osteoporose.
English: In the RUTH study, venous thromboembolic events occurred at a frequency of approximately 2.0 % or 3.88 cases per 1,000 patient-years in the raloxifene group and 1.4 % or 2.70 cases per 1,000 patient-years in the placebo group.
Danish: I RUTH-studiet forekom venøse tromboemboliske tilfælde med en frekvens på ca. 2,0% eller 3.88 tilfælde pr. 1000 patientår i raloxifengruppen og 1,4% eller 2,7 tilfælde pr. 1000 patientår i placebogruppen.
English: In a study of 10,101 postmenopausal women with documented coronary heart disease or at increased risk for coronary events (RUTH), the occurrence of vasodilatation (hot flushes) was 7.8 % in the raloxifene-treated patients and 4.7 % in the placebo-treated patients.
Danish: I et studie med 10101 postmenopausale kvinder med dokumenteret koronar hjertesygdom eller med forhøjet risiko for koronar tilfælde (RUTH), var forekomsten af vasodilation (hedeture) 7,8% hos raloxifenbehandlede patienter og 4,7% hos placebobehandlede patienter.
English: The highest overdose has been approximately 1.5 grams.
Danish: Den højeste overdosering har været på ca. 1,5 gram. Der er ikke rapporteret om død som følge af overdosering.
English: Raloxifene decreases resorption of bone; this effect on bone is manifested as reductions in the serum and urine levels of bone turnover markers, decreases in bone resorption based on radiocalcium kinetics studies, increases in BMD and decreases in the incidence of fractures.
Danish: Denne virkning på knoglevævet manifesteres som reduktioner i serum- og urinkoncentrationerne af knogleomsætningsmarkører, reduktioner i knogleresorptionen baseret på kinetiske undersøgelser med radioaktivt mærket calcium, stigninger i BMD og reduktioner i forekomsten af frakturer.
English: Very common: Gastrointestinal symptoms a such as nausea, vomiting, abdominal pain, dyspepsia
Danish: Meget almindelig: Gastrointestinale symptomera som kvalme, opkastning, abdominalsmerter, dyspepsi.
English: The majority of a dose of raloxifene and glucuronide metabolites are excreted within 5 days and are found primarily in the faeces, with less than 6 % excreted in urine.
Danish: Størstedelen af en dosis af raloxifen og glukuronidmetabolitter udskilles indenfor 5 dage og genfindes primært i fæces.
English: Active or past history of venous thromboembolic events (VTE), including deep vein thrombosis, pulmonary embolism and retinal vein thrombosis.
Danish: Aktive eller tidligere tilfælde af venøs tromboemboli (VTE), inklusiv dyb venetrombose, lungeemboli og retinal venetrombose.
English: In the 4th year alone, Optruma reduced the new vertebral fracture risk by 39 % (RR 0.61, CI 0.43, 0.88).
Danish: I det fjerde år alene reducerede Optruma risikoen for nye vertebrale frakturer med 39% (relativ risiko 0,61, konfidensinterval 0,43-0,88).
English: Optruma reduced the incidence of clinical vertebral fractures by 35% compared with placebo (HR 0.65, CI 0.47
Danish: Optruma nedsatte forekomsten af kliniske vertebrale frakturer med 35% sammenlignet med placebo (HR 0,65, konfidensinterval 0,47 - 0,89).
English: The decrease in oestrogen availability which occurs at menopause, leads to marked increases in bone resorption, bone loss and risk of fracture.
Danish: Den aftagende produktion af østrogen i menopausen, medfører en markant forøgelse af knogleresorptionen, knogletabet og risikoen for frakturer.
English: Compared with placebo-treated patients the occurrence of vasodilatation (hot flushes) was modestly increased in Optruma patients (clinical trials for the prevention of osteoporosis, 2 to 8 years postmenopausal, 24.3 % Optruma and 18.2 % placebo; clinical trials for the treatment of osteoporosis, mean age 66, 10.6 % for Optruma and 7.1 % placebo).
Danish: Sammenlignet med placebobehandlede patienter var forekomsten af vasodilatation (hedestigninger) let øget hos patienter, som blev behandlet med Optruma (kliniske studie til forebyggelse af osteoporose, 2 til 8 år postmenopausal, 24,3 % for Optruma og 18,2 % for placebo; kliniske studier til behandling af osteoporose, gennemsnitlig alder på 66 år, 10,6 % for Optruma og 7,1 % for placebo).
English: Tablet Core: Povidone, polysorbate 80, anhydrous lactose, lactose monohydrate, crospovidone, magnesium stearate.
Danish: Tabletkerne: Povidon, polysorbat 80, vandfri lactose, lactosemonohydrat, crospovidon, magnesiumstearat.
English: For oral use Read the package leaflet before use.
Danish: Læs indlægssedlen inden brug.
English: In the RUTH study, peripheral oedema occurred in 14.1 % of the raloxifene-treated patients and 11.7 % of the placebo-treated patients, which was statistically significant.
Danish: I RUTH-studiet forekom perifert ødem hos 14,1% af de raloxifenbehandlede patienter og hos 11,7% af de placebobehandlede patienter, hvilket var statistisk signifikant.
English: Peak concentrations of raloxifene are reduced with co-administration with ampicillin.
Danish: Maksimale plasmakoncentrationer af raloxifen reduceres ved samtidig administration af ampicillin.
English: Results from single oral doses of raloxifene predict multiple dose pharmacokinetics.
Danish: Resultater fra perorale enkeltdoser af raloxifen tyder på flerdosiskinetik.
English: Very common: Vasodilation (hot flushes) Uncommon: Venous thromboembolic events, including deep vein thrombosis, pulmonary embolism, retinal vein thrombosis, superficial vein thrombophlebitis, Arterial thromboembolic reactions a
Danish: Meget almindelig: Vasodilatation (hedestigninger) Ikke almindelig: Venøse tromboemboliske tilfælde, inklusive dyb venetrombose, lungeemboli, retinal venetrombose, tromboflebitis i overfladiske vener, arterielle tromboemboliske bivirkningera
English: A reduction in the risk of hip fractures has not been shown.
Danish: En nedsat risiko for hoftebrud er ikke set.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING BLISTER BOX FILM COATED TABLETS:
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE BLISTERPAKNING FILMOVERTRUKNE TABLETTER
English: Raloxifene modestly increases hormone-binding globulin concentrations, including sex steroid binding globulins (SHBG), thyroxine binding globulin (TBG), and corticosteroid binding globulin
Danish: Raloxifen øger i beskedent omfang koncentrationerne af hormonbindende globulin, inklusiv kønshormonbindende globuliner (SHBG), thyroxinbindende globulin (TBG) og kortikosteroidbindende globulin (CBG) med tilsvarende stigninger i totale hormonkoncentrationer.
English: The recommended dose is one tablet daily by oral administration, which may be taken at any time of the day without regard to meals.
Danish: Tabletten kan tages på et hvilket som helst tidspunkt af dagen uden hensyntagen til måltider.
English: Therefore Optruma is not recommended to be used in patients with hepatic insufficiency.
Danish: Derfor kan Optruma ikke anbefales til patienter med nedsat leverfunktion.
English: Optruma has no or negligible effects on driving or using machines.
Danish: Trafik- og arbejdssikkerhed Optruma påvirker ikke eller kun i ubetydelig grad evnen til at køre bil eller betjene maskiner.
English: • If you have liver disease (examples of liver disease include cirrhosis, mild hepatic impairment or cholestatic jaundice).
Danish: • hvis De har en leversygdom (eksempler på leversygdomme omfatter skrumpelever, let nedsat leverfunktion og gulsot på grund af afløbshindring).
English: In a study (RUTH) of postmenopausal women with documented coronary heart disease or at increased risk for coronary events, an additional adverse reaction of cholelithiasis occurred in 3.3 % of patients treated with raloxifene and 2.6 % of patients treated with placebo.
Danish: I et studie (RUTH) med postmenopausale kvinder med dokumenteret koronar hjertesygdom eller med forhøjet risiko for koronar tilfælde, sås cholelithiasis som en yderligere bivirkning hos 3,3% af de patienter, der blev behandlet med raloxifen, mens tallet var 2,6% for patienterne, der fik placebo.
English: Similarly, in the RUTH study, raloxifene did not affect the incidence of myocardial infarction, hospitalized acute coronary syndrome, stroke or overall mortality, including overall cardiovascular mortality, compared to placebo (for the increase in risk of fatal stroke see section 4.4).
Danish: Tilsvarende sås i RUTH-studiet at raloxifen ikke påvirkede hyppigheden af hjerteinfarkt, indlæggelse på grund af akut hjertesygdom, apopleksi eller samlet dødelighed, inklusive samlet kardiovasculær dødelighed set i forhold til placebo (for forhøjet risiko for fatalt slagtilfælde, se pkt.
English: The most common side effects (affects more than 1 user in 10) are:
Danish: Meget almindelig (kan ramme mere end 1 af 10 patienter):
English: Eli Lilly Nederland B.V., Papendorpseweg 83, 3528 BJ Utrecht, The Netherlands
Danish: Eli Lilly Nederland B.V Papendorpseweg 83 3528 BJ Utrecht Holland
English: In a study of postmenopausal women with documented coronary heart disease or at increased risk for coronary events, raloxifene did not affect the incidence of myocardial infarction, hospitalized acute coronary syndrome, overall mortality, including overall cardiovascular mortality, or stroke, compared to placebo.
Danish: I et studie med postmenopausale kvinder med dokumenteret koronar hjertesygdom eller forhøjet risiko for koronar hjertesygdom påvirkede raloxifen ikke forekomsten af hjerteinfarkt, indlæggelser med akut koronar hjertesygdom, total dødelighed, medregnet total kardiovaskulær dødelighed, eller apopleksi sammenlignet med placebo.
English: Limited clinical data suggest that in patients with a history of oral oestrogen-induced hypertriglyceridemia (>5.6 mmol/l), raloxifene may be associated with a marked increase in serum triglycerides.
Danish: Begrænsede kliniske data tyder på at raloxifen kan være forbundet med en mærkbar øgning i serumtriglycerid hos patienter der tidligere har haft oral østrogeninduceret hypertriglyceridæmi (>5,6 mmol/l).
English: Anhydrous lactose Lactose monohydrate Crospovidone
Danish: Vandfri lactose Lactosemonohydrat Crospovidon Magnesiumstearat
English: Another adverse reaction observed was leg cramps (5.5 % for Optruma, 1.9 % for placebo in the prevention population and 9.2 % for Optruma, 6.0 % for placebo in the treatment population).
Danish: En anden observeret bivirkning var kramper i benene (5,5 % for Optruma og 1,9 % for placebo blandt deltagere i studier til forebyggelse af osteoporose og 9,2 % for Optruma og 6,0 % for placebo blandt deltagere i studie til behandling af osteoporose).
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Danish: Fortæl altid lægen eller apotekspersonalet, hvis De bruger anden medicin eller har gjort det for nylig.
English: Ink:
Danish: SN:
English: In the RUTH study, leg cramps were observed in 12.1 % of raloxifene-treated patients and 8.3 % of placebo-treated patients.
Danish: I RUTH-studiet blev kramper i benene observeret hos 12,1% af de raloxifenbehandlede patienter og hos 8,3% af de placebobehandlede patienter.
English: Propylene glycol Indigo carmine (E 132)
Danish: Propylenglycol Indigotin I (E132).
English: • If you have any unexplained vaginal bleeding.
Danish: • hvis De af ukendt årsag har blødning fra underlivet.
English: In a study of 7,705 postmenopausal women with a mean age of 66 years and with osteoporosis or osteoporosis with an existing fracture, Optruma treatment for 3 years reduced the incidence of vertebral fractures by 47 % (RR 0.53, CI 0.35, 0.79; p < 0.001) and 31 % (RR 0.69, CI 0.56, 0.86; p < 0.001) respectively.
Danish: I en undersøgelse af 7.705 postmenopausale kvinder med en gennemsnitlig alder på 66 år og med osteoporose eller osteoporose med en eksisterende fraktur, reducerede 3 års behandling med Optruma forekomsten af vertebrale frakturer med henholdsvis 47 % (relativ risiko 0,53, konfidensinterval 0,35-0,79; p < 0,001) og 31 % (relativ risiko 0,69, konfidensinterval 0,560,86; p < 0,001).
English: Although it may have no symptoms at first, osteoporosis makes you more likely to break bones, especially in your spine, hips and wrists and may cause back pain, loss of height and a curved back.
Danish: Selvom knogleskørhed i begyndelsen ikke giver symptomer, kan den øge risikoen for, at De brækker Deres knogler, specielt rygsøjlen, hofterne og håndleddene.
English: As safety information regarding co-administration of raloxifene with systemic oestrogens is limited, such use is not recommended.
Danish: Information omkring sikkerhed ved samtidig administration af raloxifen og systemisk østrogen er begrænset.
English: • Increased risk of blood clots in the legs (deep vein thrombosis)
Danish: • Øget risiko for blodpropper i benene (dyb venetrombose)
English: Talk to your doctor or pharmacist before you take Optruma.
Danish: Advarsler og forsigtighedsregler Kontakt lægen eller apoteketspersonalet, før De tager Optruma
English: In the prevention trials, the percentage of subjects experiencing an increase or decrease in BMD during raloxifene therapy was: for the spine 37 % decreased and 63 % increased; and for the total hip 29 % decreased and 71 % increased.
Danish: I studier til forebyggelse af osteoporose var den procentdel af studie personer, som oplevede en forøgelse eller en reduktion af BMD under behandling med raloxifen, henholdsvis 63 % og 37 % for rygsøjlen og henholdsvis 71 % og 29 % for hoften.
English: • If you are receiving oral oestrogen therapy.
Danish: • hvis De tager hormontabletter med østrogen.
English: Optruma produced significant increases in bone density of hip and spine as well as total body mineral mass compared to placebo.
Danish: Optruma øgede knoglemineraltætheden i hofte og rygsøjle samt knoglemassen i hele kroppen signifikant i forhold til placebo.
English: <2D barcode carrying the unique identifier included.>
Danish: 17 ENTYDIG IDENTIFIKATOR - 2D-STREGKODE Der er anført en 2D-stregkode, som indeholder en entydig identifikator.
English: If you wish you may take a glass of water with it. Do not break or crush the tablet before taking it. A broken or crushed tablet may taste bad and there is a possibility that you will receive an incorrect dose.
Danish: En delt eller knust tablet kan smage dårligt, og der er risiko for, at De får en forkert dosis.
English: • Increased risk of blood clots in the eyes (retinal vein thrombosis)
Danish: • Øget risiko for blodproper i øjet (nethinde venetrombose)
English: Uncommon: Fatal strokes
Danish: Almindelig: Perifert ødem
English: Optruma should not be used in patients with severe renal impairment (see section 4.3).
Danish: Optruma bør ikke anvendes til patienter med svært nedsat nyrefunktion (se pkt.
English: • If there is still a possibility that you can get pregnant, Optruma could harm your unborn child.
Danish: • hvis De stadigvæk har mulighed for at blive gravid.
English: - The active substance is raloxifene hydrochloride.
Danish: - Aktivt stof: raloxifenhydrochlorid.
English: Raloxifene treated women consistently had an endometrial thickness which was indistinguishable from placebo.
Danish: Raloxifenbehandlede kvinder havde en endometrietykkelse, som ikke var forskellig fra placebo.
English: Each tablet contains 60 mg of raloxifene hydrochloride, which is equivalent to 56 mg raloxifene.
Danish: Hver tablet indeholder 60 mg raloxifenhydrochlorid, hvilket svarer til 56 mg raloxifen.
English: The relative risk of venous thromboembolic events observed during raloxifene treatment was 1.60 (CI 0.95, 2.71) when compared to placebo, and was 1.0 (CI 0.3, 6.2) when compared to oestrogen or hormonal replacement therapy.
Danish: Den relative risiko for venøse tromboemboliske tilfælde, som er observeret under raloxifenbehandling, var 1,60 (konfidensinterval 0,95-2,71) i forhold til placebo og 1,0 (konfidensinterval 0,3-6,2) i forhold til østrogen eller hormonal substitutionsterapi.
English: Common side effects (affects 1 to 10 users in 100) are:
Danish: Almindelig (kan ramme 1 til 10 ud af 100 patienter):
English: Optruma treatment for 4 years reduced the incidence of vertebral fractures by 46 % (RR 0.54, CI 0.38, 0.75) and 32 % (RR 0.68, CI 0.56, 0.83) in patients with osteoporosis or osteoporosis with an existing fracture respectively.
Danish: Behandling med Optruma i 4 år reducerede forekomsten af vertebrale frakturer med 46% (relativ risiko 0,54, konfidensinterval 0,38-0,75) og 32% (relativ risiko 0,68, konfidensinterval 0,560,83) hos patienter med henholdsvis osteoporose eller osteoporose med en eksisterende fraktur.
English: However, modest decreases in the prothrombin time have been observed, and if raloxifene is given concurrently with warfarin or other coumarin derivatives, the prothrombin time should be monitored.
Danish: Hvis raloxifen gives samtidig med warfarin eller andre coumarinderivater, bør protrombintiden derfor overvåges.
English: In the prevention population discontinuations of therapy due to any adverse reaction occurred in 10.7 % of 581 Optruma treated patients and 11.1 % of 584 placebo-treated patients.
Danish: Blandt deltagere i studier til forebyggelse af osteoporose forekom behandlingsophør som følge af enhver bivirkning hos 10,7 % af 581 Optruma-behandlede patienter og hos 11,1 % af 584 placebobehandlede patienter.
English: In the treatment population discontinuations of therapy due to any clinical adverse event occurred in 12.8 % of 2,557 Optruma treated patients and 11.1 % of 2,576 placebo treated patients.
Danish: Blandt deltagere i studier til behandling af osteoporose forekom behandlingsophør som følge af enhver bivirkning hos 12,8 % af 2.557 Optruma-behandlede patienter og hos 11,1 % af 2.576 placebo-behandlede patienter.
English: Over the 4 years of the osteoporosis treatment trial (involving 7,705 patients), Optruma treatment compared to placebo reduced the risk of total breast cancer by 62 % (RR 0.38; CI 0.21, 0.69), the risk of invasive breast cancer by 71 % (RR 0.29, CI 0.13, 0.58) and the risk of invasive oestrogen receptor (ER) positive breast cancer by 79 % (RR 0.21, CI 0.07, 0.50).
Danish: I løbet af de 4 års osteoporosebehandlings studier (med 7705 patienter), reducerede Optrumabehandling risikoen for brystcancer i forhold til placebo med 62% (relativ risiko 0,38, konfidensinterval 0,21-0,69), risikoen for invasiv brystcancer med 71% (relativ risiko 0,29, konfidensinterval 0,13-0,58) samt risikoen for invasiv østrogenreceptor-positiv brystcancer med 79% (relativ risiko 0,21, konfidensinterval 0,07-0,50).
English: 3528 BJ Utrecht The Netherlands
Danish: Papendorpseweg 83 3528 BJ Utrecht Holland
English: In rats retardation of foetal development, wavy ribs and kidney cavitation occurred (≥ 1 mg/kg).
Danish: Hos rotter forekom forsinket fosterudvikling, bølgeformede ribben og hulheder i nyrer (≥1 mg/kg).
English: • Flu syndrome
Danish: • Influenzasymptomer
English: Fewer Optruma treated women than placebo treated women required surgical intervention for uterine prolapse.
Danish: Færre Optruma-behandlede kvinder havde behov for et operativt indgreb for uterint prolaps end placebo-behandlede kvinder.
English: What you need to know before you take Optruma Do not take Optruma:
Danish: Det skal De vide, før De begynder at tage Optruma Sådan skal De tage Optruma Bivirkninger
English: OPTRUMA 60 mg film coated tablets raloxifene hydrochloride
Danish: Optruma 60 mg filmovertrukne tabletter raloxifenhydrochlorid
English: Optruma reduces the risk of vertebral fractures in women with postmenopausal osteoporosis.
Danish: Optruma nedsætter risikoen for brud på rygsøjlen hos kvinder med knogleskørhed efter overgangsalderen.
English: It is important that you continue taking Optruma for as long as your doctor prescribes the medicine, Optruma can treat or prevent your osteoporosis only if you continue to take the tablets.
Danish: Optruma kan kun behandle eller forebygge knogleskørhed, hvis De fortsætter med at tage tabletterne.
English: How to take Optruma
Danish: Sådan skal De tage Optruma