FrancophonIA/ELRC3.0 huggingface dataset:
English: Where clinically appropriate, direct change from glimepiride monotherapy to AVAGLIM may be considered.
Slovenian: Če je klinično primerno, pride v poštev neposreden prehod z monoterapije z glimepiridom na AVAGLIM.
English: Absolute bioavailability of rosiglitazone following both a 4 and an 8 mg oral dose is approximately 99%.
Slovenian: Absolutna biološka uporabnost rosiglitazona je po 4-mg in po 8-mg peroralnem odmerku približno 99 %.
English: Hepatic impairment: Following rosiglitazone treatment in cirrhotic patients with moderate (ChildPugh B) hepatic impairment, unbound Cmax and AUC were 2- and 3-fold higher than in normal subjects.
Slovenian: Okvara jeter: Po zdravljenju bolnikov s cirozo in zmerno (Child-Pugh B) okvaro jeter z rosiglitazonom sta bili Cmax oz. AUC 2- oz. 3-krat večji kot pri zdravih preiskovancih.
English: Nevertheless, the potential for hypoglycaemia should be borne in mind when considering the patient's ability to perform tasks that require judgement, motor or cognitive skills (e.g. driving).
Slovenian: Pri ocenjevanju bolnikove zmožnosti za izvajanje opravil, ki zahtevajo presojo in motorične ali kognitivne sposobnosti (npr. upravljanje vozil), je kljub temu treba upoštevati možnost hipoglikemije.
English: Signs include:
Slovenian: Takšna zdravila so npr.:
English: The major route of excretion is the urine with approximately two-thirds of the dose being eliminated by this route, whereas faecal elimination accounts for approximately 25% of dose.
Slovenian: Tako se izločita približno dve tretjini odmerka, medtem ko gre na račun izločanja v blatu približno 25 % odmerka.
English: Tell your doctor or pharmacist if you are taking any other medicines, if you've taken any recently, or if you start taking new ones.
Slovenian: Obvestite svojega zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali boste začeli jemati katerokoli novo zdravilo, vključno z zdravili iz zelišč in drugimi zdravili, ki jih lahko dobite brez
English: The following statements reflect the information available on the individual active substances (rosiglitazone and glimepiride).
Slovenian: Naslednje navedbe temeljijo na informacijah, ki so na voljo za posamezni zdravilni učinkovini (rosiglitazon in glimepirid).
English: The following statements refer to AVAGLIM or the two individual active substances (rosiglitazone
Slovenian: Naslednje navedbe veljajo za AVAGLIM ali posamezni zdravilni učinkovini (rosiglitazon in
English: Glimepiride increases the activity of glycosyl-phosphatidylinositol-specific phospholipase C, which may be associated with drug-induced lipogenesis and glycogenesis in isolated fat and muscle cells.
Slovenian: Glimepirid poveča aktivnost za glikozil-fosfatidilinozitol specifične fosfolipaze C. To je morda povezano z indukcijo lipogeneze in glikogeneze, ki jo zdravilo povzroči v izoliranih maščobnih in
English: Rosiglitazone was associated with increases in weight.
Slovenian: Rosiglitazon je bil povezan s povečanjem telesne mase.
English: Liver problems: Before you start taking Avaglim you will have a blood sample taken to check your liver function.
Slovenian: Težave z jetri: Pred začetkom zdravljenja z zdravilom Avaglim bo zdravnik s krvno preiskavo preveril delovanje jeter.
English: As a consequence of different but complementary mechanisms of action, dual oral therapy of rosiglitazone with a sulphonylurea or metformin resulted in additive effects on glycaemic
Slovenian: Zaradi različnih, vendar komplementarnih mehanizmov delovanja je imelo dvotirno zdravljenje z rosiglitazonom ter sulfonilsečnino ali metforminom pri bolnikih z diabetesom tipa 2 aditivne učinke na urejenost glikemije.
English: Mild or moderate renal impairment (creatinine clearance 30 to 80 ml/min): - Patients changing to AVAGLIM from sulphonylurea therapies other than glimepiride may be at an increased risk of hypoglycaemia (see section 4.4).
Slovenian: Blaga ali zmerna okvara ledvic (očistek kreatinina od 30 do 80 ml/min): - Bolnike, ki preidejo na AVAGLIM z drugih sulfonilsečnin kot z glimepirida, lahko bolj ogroža hipoglikemija (glejte poglavje 4.4).
English: If glimepiride is taken simultaneously with certain other medicines, both undesired increases and decreases in the hypoglycaemic action of glimepiride can occur.
Slovenian: Med sočasno uporabo glimepirida z nekaterimi drugimi zdravili se lahko pojavi tako neželeno povečanje kot zmanjšanje učinka glimepirida na znižanje krvnega sladkorja.
English: It is best to take Avaglim with food, or just before food, usually with your first main meal of the day.
Slovenian: Najbolje je, da zdravilo Avaglim jemljete skupaj s hrano ali neposredno pred hrano, navadno s
English: Premenopausal women have received rosiglitazone during clinical studies.
Slovenian: V kliničnih študijah so rosiglitazon dobivale ženske pred menopavzo.
English: • lower blood sugar than normal (hypoglycaemia)
Slovenian: • prekomerno znižanje vrednosti krvnega sladkorja (hipoglikemija)
English: H2 antagonists, betablockers, clonidine and reserpine may lead to either potentiation or weakening of
Slovenian: Zaviralci H2, zaviralci beta, klonidin in reserpin lahko učinek na znižanje glukoze v krvi povečajo ali
English: In patients with low haemoglobin levels before initiating therapy, there is an increased risk of anaemia during
Slovenian: Pri bolnikih, ki imajo pred začetkom zdravljenja nizek hemoglobin, obstaja med zdravljenjem z
English: Elderly: In the pooled population pharmacokinetic analysis, age was not found to influence the pharmacokinetics of rosiglitazone or glimepiride to any significant extent.
Slovenian: Starejši: Kumulativna populacijska farmakokinetična analiza ni pokazala, da bi starost kakorkoli pomembno vplivala na farmakokinetiko rosiglitazona ali glimepirida.
English: 11 Hypersensitivity reactions of the skin may occur as itching, rash and urticaria.
Slovenian: 11 Pojavijo se lahko preobčutljivostne reakcije kože, npr. srbenje, izpuščaj ali urtikarija.
English: Pink, rounded triangular tablet with “gsk” debossed on one side and “4/4” on the other side.
Slovenian: Rožnate, zaokrožene trikotne tablete z vtisnjeno oznako "gsk" na eni strani in "4/4" na drugi.
English: No animal studies have been conducted with the combined products in AVAGLIM.
Slovenian: S kombinacijo zdravil v AVAGLIMU niso izvedli nobenih študij na živalih.
English: A study comparing AVAGLIM to monotherapy rosiglitazone or glimepiride demonstrated incremental benefit in control of glycaemia of the fixed-dose combination over monotherapy.
Slovenian: Študija, v kateri so AVAGLIM primerjali z monoterapijo z rosiglitazonom ali glimepiridom, je pokazala, da kombinacija fiksnih odmerkov v primerjavi z monoterapijo prinaša dodatno korist pri uravnavanju glikemije.
English: Renal insufficiency: There are no clinically significant differences in the pharmacokinetics of rosiglitazone in patients with renal impairment or end stage renal disease on chronic dialysis.
Slovenian: Insuficienca ledvic: Farmakokinetika rosiglitazona se pri bolnikih z okvaro ledvic ali končno boleznijo ledvic na kronični dializi ne razlikuje klinično pomembno.
English: • swelling (oedema) due to water retention.
Slovenian: • oteklina (edem) zaradi zastajanja vode v telesu
English: Periodic haematological monitoring (especially leucocytes and thrombocytes) are required during
Slovenian: Med zdravljenjem z AVAGLIMOM je potreben občasen hematološki nadzor (zlasti levkocitov in
English: No parent drug was recovered from urine or faeces.
Slovenian: V urinu ali blatu se ni pojavilo nič matičnega zdravila.
English: MARKETING AUTHORISATION HOLDER SmithKline Beecham Ltd, 980 Great West Road, Brentford, Middlesex, TW8 9GS, United Kingdom.
Slovenian: Imetnik dovoljenja za promet z zdravilom: SmithKline Beecham Ltd, 980 Great West Road, Brentford, Middlesex, TW8 9GS, Velika Britanija.
English: • rapid and excessive weight gain caused by fluid retention
Slovenian: • hitro in močno povečanje telesne mase zaradi kopičenja tekočine v telesu
English: If you accidentally take too many tablets, contact your doctor or pharmacist for advice.
Slovenian: Če ste vzeli večji odmerek zdravila Avaglim, kot bi smeli Če po nesreči vzamete preveč tablet, se posvetujte s svojim zdravnikom ali farmacevtom.
English: Studies with single oral doses in normal subjects and with multiple oral doses in patients with type 2 diabetes mellitus have shown significant absorption of glimepiride within 1 h after administration and Cmax at approximately 2.5 h. There is a linear relationship between dose and both Cmax and AUC.
Slovenian: Študije s posamičnimi peroralnimi odmerki pri zdravih preiskovancih in z večkratnimi peroralnimi odmerki pri bolnikih z diabetesom mellitusom tipa 2 so pokazale pomembno absorpcijo glimepirida v 1 uri po uporabi in Cmax po približno 2,5 ure.
English: Transient visual disturbances may occur especially on initiation of treatment, due to changes in blood
Slovenian: Zaradi sprememb vrednosti glukoze v krvi se lahko pojavijo prehodne motnje vida, še posebej na začetku zdravljenja.
English: No data are available with regard to overdose of AVAGLIM.
Slovenian: Podatkov o prevelikem odmerjanju AVAGLIMA ni.
English: • reduction in the number of red blood cells, or a type of white blood cell (granulocytopaenia)
Slovenian: • Zmanjšanje števila rdečih krvnih celic, ali ene vrste belih krvnih celic (granulocitopenija), ki je lahko huda (agranulocitoza) ali zmanjšanje števila vseh vrst krvnih celic (pancitopenija)
English: In addition, rosiglitazone preserved ß-cell function as shown by increased pancreatic islet mass and insulin content and prevented the development of overt hyperglycaemia in animal models of type 2 diabetes.
Slovenian: Poleg tega je rosiglitazon v živalskih modelih diabetesa tipa 2 ohranil delovanje celic β, kot dokazujeta povečana masa pankreatičnih otočkov in vsebnost insulina, ter je preprečil pojav manifestne hiperglikemije.
English: In vitro studies demonstrate that rosiglitazone is predominantly metabolised by CYP2C8, with CYP2C9 as only a minor pathway.
Slovenian: Študije in vitro kažejo, da se rosiglitazon presnavlja predvsem s CYP2C8, CYP2C9 pa je le manj pomembna pot.
English: Insulin should only be added to established rosiglitazone therapy in exceptional cases
Slovenian: Zdravljenje z insulinom se lahko k že uvedenemu zdravljenju z rosiglitazonom uvede le v izjemnih primerih in pod
English: Driving and using machines Avaglim can make you dizzy or cause your blood sugar to become lower than normal (see ‘Low blood
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Avaglim lahko povzroči omotico ali zniža normalno vrednost vašega krvnega sladkorja (glejte ‘Nizka vrednost krvnega sladkorja' v poglavju 4).
English: You must look out for certain symptoms while you are taking Avaglim, to reduce the risk of any problems.
Slovenian: Da bi zmanjšali tveganje za pojav kakršnihkoli težav morate biti med jemanjem zdravila Avanglim pozorni na nekatere simptome.
English: Thiazolidinediones act primarily by reducing insulin resistance and sulphonylureas act primarily by stimulating release of insulin from functioning pancreatic β-cells.
Slovenian: Primarni učinek tiazolidindionov je zmanjšanje odpornosti proti insulinu, primarni učinek sulfonilsečnin pa spodbujanje sproščanja insulina iz delujočih celic β v pankreasu.
English: Once glycaemic control is stable at these doses, AVAGLIM may be introduced at a starting dose of 4 mg rosiglitazone/4 mg glimepiride
Slovenian: Ko je glikemija s temi odmerki urejena, je mogoče uvesti AVAGLIM v začetnem odmerku 4 mg rosiglitazona/4 mg glimepirida enkrat na dan.
English: It cannot be excluded that other inducers (e.g. phenytoin, carbamazepine, phenobarbital, St John's wort) may also affect rosiglitazone exposure.
Slovenian: Vpliva drugih induktorjev (npr. fenitoina, karbamazepina, fenobarbitala, šentjanževke) ni mogoče izključiti.
English: An adverse reaction is only presented for the fixed dose combination if it has not been seen in one of the component parts of AVAGLIM or if it occurred at a higher frequency than that listed for a component part.
Slovenian: Neželeni učinki kombinacije v fiksnem odmerku so navedeni le, če pri posamezni zdravilni učinkovini zdravila AVAGLIM niso bili ugotovljeni, oziroma je bila njihova pogostnost večja od pogostnosti pri
English: The usual starting dose is one combined tablet (4 mg rosiglitazone and 4 mg glimepiride), taken once
Slovenian: Običajni začetni odmerek je ena kombinirana tableta (4 mg rosiglitazona in 4 mg glimepirida) enkrat
English: Before therapy is initiated with AVAGLIM appropriate clinical evaluation should be made to assess the patient's risk of developing
Slovenian: Pred uvedbo terapije z AVAGLIMOM je treba ustrezno klinično oceniti bolnikovo ogroženost s hipoglikemijami (glejte
English: In vitro studies demonstrate that rosiglitazone is predominantly metabolised by CYP2C8, with a minor
Slovenian: Študije in vitro so pokazale, da se rosiglitazon pretežno presnavlja s CYP2C8, ob manjšem prispevku
English: Heart failure was also reported more frequently in patients with a history of heart failure; oedema and heart failure was also reported more frequently in elderly patients and in patients with mild or moderate renal failure.
Slovenian: O edemih in srčnem popuščanju so pogosteje poročali tudi pri starejših bolnikih in bolnikih z blago ali zmerno odpovedjo ledvic.
English: No clinically relevant interactions with digoxin, the CYP2C9 substrate warfarin, the CYP3A4 substrates nifedipine, ethinylestradiol or norethindrone were observed after co-administration with
Slovenian: Po hkratni uporabi z rosiglitazonom niso opazili klinično pomembnega medsebojnega delovanja z digoksinom, substratom CYP2C9 varfarinom in substrati CYP3A4 nifedipinom, etinilestradiolom oz.
English: Each tablet contains either: 4 mg or 8 mg rosiglitazone and 4 mg glimepiride.
Slovenian: Ena tableta vsebuje: 4 mg ali 8 mg rosiglitazona in 4 mg glimepirida.
English: Rosiglitazone treatment is associated with a dose-related reduction of haemoglobin levels.
Slovenian: Zdravljenje z rosiglitazonom spremlja z odmerkom povezano znižanje koncentracije hemoglobina.
English: Rosiglitazone treatment significantly reduced the risk of reaching monotherapy failure (FPG>10.0 mmol/L) by 63% relative to glibenclamide (HR 0.37, CI 0.30-0.45) and by 32% relative to metformin (HR 0.68,
Slovenian: Med študijo (do 72 mesecev zdravljenja) je zdravljenje z rosiglitazonom statistično značilno zmanjšalo tveganje odpovedi monoterapije (glukoza v plazmi na tešče > 10,0 mmol/l) za 63 % v primerjavi z glibenklamidom (razmerje ogroženosti 0,37, interval zaupanja 0,30-0,45) in za 32 % v primerjavi z metforminom (razmerje ogroženosti 0,68, interval zaupanja 0,55-0,85).
English: Therefore, AVAGLIM should not be used during lactation.
Slovenian: Zato AVAGLIMA ne smete uporabljati med obdobjem dojenja.
English: phenylbutazone, azapropazon and oxyfenbutazone,
Slovenian: fenilbutazon, azapropazon ali oksifenbutazon,
English: Reproduction toxicology findings may be related to the pharmacodynamic action of glimepiride.
Slovenian: Izsledke reproduktivnih toksičnih učinkov je mogoče povezati s farmakodinamičnim delovanjem
English: The maximum recommended daily dose is 8 mg rosiglitazone/4 mg glimepiride (given as one AVAGLIM tablet 8 mg/4 mg, once daily).
Slovenian: Največji priporočeni dnevni odmerek je 8 mg rosiglitazona/4 mg glimepirida (v obliki ene tablete AVAGLIM 8 mg/4 mg enkrat na dan).
English: There have been rare reports of hepatocellular dysfunction during post-marketing experience with rosiglitazone (see section 4.8).
Slovenian: Med obdobjem pomarketinške uporabe rosiglitazona so poročali o redkih primerih motenega delovanja jetrnih celic (glejte poglavje 4.8).
English: certain long acting sulphonamides, tetracyclines,
Slovenian: sulfinpirazon, nekateri dolgodelujoči sulfonamidi, tetraciklini, zaviralci MAO,
English: The frequency of adverse reactions identified from post-marketing data with rosiglitazone
Slovenian: Pogostnost neželenih učinkov na osnovi podatkov po pridobitvi dovoljenja za promet z rosiglitazonom
English: Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site:
Slovenian: − na zahtevo Evropske agencije za zdravila (EMEA).
English: GlaxoSmithKline BV Tel: + 31 (0)30 6938100 nlinfo@gsk.com
Slovenian: GlaxoSmithKline BV Tel: + 31 (0)30 6938100 nlinfo@gsk.com Norge
English: In a monotherapy study, the incidence in females for rosiglitazone was 9.3% (2.7 patients per 100 patient years) vs 5.1% (1.5 patients per 100 patient years) for metformin or 3.5% (1.3 patients per 100 patient years) for glibenclamide.
Slovenian: 4 Dolgoročne študije kažejo večjo incidenco zlomov kosti pri osebah, zlasti ženskah, ki jemljejo rosiglitazon V študiji monoterapije je bila incidenca pri ženskah, ki so jemale rosiglitazon, 9,3 % (2,7 bolnice na 100 bolnikov-let) v primerjavi s 5,1 % (1,5 bolnice na 100 bolnikov-let) za metformin in s 3,5 % (1,3 bolnice na 100 bolnikov-let) za glibenklamid.
English: Co-administration of rosiglitazone with gemfibrozil (an inhibitor of CYP2C8) resulted in a twofold increase in rosiglitazone plasma concentrations.
Slovenian: Med sočasno uporabo rosiglitazona in gemfibrozila (zaviralca CYP2C8) se je koncentracija rosiglitazona v plazmi dvakrat povečala.
English: As a consequence of improving insulin sensitivity, resumption of ovulation may occur in patients who are anovulatory due to insulin resistance.
Slovenian: Pri bolnicah, ki nimajo ovulacije zaradi odpornosti proti insulinu, se zaradi izboljšane občutljivosti za insulin lahko ovulacija znova pojavi.
English: There are no data from the use of glimepiride in patients on renal dialysis (see section 4.3).
Slovenian: O uporabi glimepirida pri bolnikih na dializi ni zadostnih podatkov (glejte poglavje 4.3).
English: Table 3 presents adverse reactions by system organ class and by frequency category based on experience with glimepiride and other sulphonylureas.
Slovenian: Podatki iz kliničnih preskušanj in podatki po pridobitvi dovoljenja za promet V preglednici 3 so navedeni neželeni učinki glede na organski sistem in kategorijo pogostnosti na osnovi izkušenj z glimepiridom in drugimi sulfonilsečninami.
English: Since NSAIDs and rosiglitazone are associated with fluid retention, concomitant administration may increase the risk of oedema.
Slovenian: Ker so nesteroidna protivnetna zdravila in rosiglitazon povezani z zastajanjem tekočine, lahko sočasna uporaba teh zdravil poveča tveganje za edeme.
English: Alcohol intake may potentiate or weaken the hypoglycaemic action of glimepiride in an unpredictable
Slovenian: Pitje alkohola lahko nepredvidljivo poveča ali zmanjša učinek glimepirida na znižanje krvnega
English: Blood and the lymphatic system disorders
Slovenian: Bolezni krvi in limfatičnega sistema agranulocitoza
English: Glimepiride is completely metabolised by oxidative biotransformation after either an intravenous or oral dose.
Slovenian: Glimepirid se tako po intravenski kot po peroralni uporabi povsem presnovi z oksidativno biotransformacijo.
English: 5 Rare cases of elevated liver enzymes and hepatocellular dysfunction have been reported.
Slovenian: 5 V pomarketinškem obdobju so bili opisani redki primeri zvišanja jetrnih encimov in motenega delovanja jetrnih celic.
English: The majority of the fractures were reported in the upper limbs and distal lower limbs (see
Slovenian: Večina zlomov je bila zabeležena na zgornjih udih in distalnih delih spodnjih udov (glejte poglavje 4.4).
English: Frequencies are defined as: very common ≥ 1/10; common ≥ 1/100, < 1/10; and uncommon ≥ 1/1000, < 1/100.
Slovenian: Pogostnost je definirana kot: zelo pogosti (≥ 1/10), pogosti (≥ 1/100, < 1/10) in občasni (≥ 1/1.000,
English: • Don't breast-feed while you are taking Avaglim.
Slovenian: • Med jemanjem zdravila Avaglim ne smete dojiti.
English: Total plasma clearance of rosiglitazone is around 3 l/h and the terminal elimination half-life of rosiglitazone is approximately 3-4 h. There is no evidence for unexpected accumulation of rosiglitazone after once or twice daily dosing.
Slovenian: Celotni plazemski očistek rosiglitazona je okrog 3 l/uro, njegov terminalni razpolovni čas izločanja pa približno 3 do 4 ure.
English: After about 8 weeks your doctor may need to increase your dose.
Slovenian: Po 8 tednih jenanja zdravila Avaglim, vam lahko zdravnik odmerek zviša.
English: Its metabolism is known to be influenced by concomitant administration of CYP2C9 inducers (e.g. rifampicin) or inhibitors (e.g.
Slovenian: Znano je, da na njegovo presnovo vpliva sočasna uporaba induktorjev CYP2C9 (npr. rifampicina) ali zaviralcev CYP2C9 (npr. flukonazola).
English: 2 An increased incidence of heart failure has been observed when rosiglitazone was added to treatment regimens with a sulphonylurea (either as dual or triple therapy), and appeared higher with 8 mg rosiglitazone compared to 4 mg rosiglitazone (total daily dose).
Slovenian: 2 Če so rosiglitazon dodali k režimu zdravljenja s sulfonilsečnino (bodisi pri zdravljenju z dvema zdravilnima učinkovinama bodisi pri zdravljenju s tremi zdravilnimi učinkovinami), so opazili večjo pojavnost srčnega popuščanja, ki je bila pri 8 mg odmerku rosiglitazona večja kot pri 4 mg odmerku (skupni dnevni odmerek).
English: There is limited experience with rosiglitazone in patients with elevated liver enzymes (ALT >2.5X upper limit of normal).
Slovenian: Izkušnje pri bolnikih z zvišanimi jetrnimi encimi (ALT > 2,5-krat zgornja normalna meja) so omejene.
English: Take your tablets around the same time every day and follow any dietary advice that your doctor has
Slovenian: Upoštevajte vse zdravnikove nasvete o dietni
English: No intact active substance is excreted in urine or faeces.
Slovenian: V urinu ali blatu se ne izloči nič nespremenjene zdravilne učinkovine.
English: If you have kidney disease, or are over 65, your kidney function should be checked while you are
Slovenian: Med jemanjem zdravila Avaglim je treba preverjati delovanje ledvic, če ste starejši od 65 let ali če imate
English: CYP2C9 has been shown to be involved in the biotransformation of glimepiride to M1. M1 is further metabolised to M2 by one or several cytosolic enzymes.
Slovenian: Ugotovljeno je, da je v biotransformacijo glimepirida v M1 vpleten CYP2C9.
English: Rosiglitazone did not stimulate pancreatic insulin secretion or induce hypoglycaemia in rats and mice.
Slovenian: Rosiglitazon pri podganah in miših ni stimuliral pankreatičnega izločanja insulina in ni izzval hipoglikemije.
English: AVAGLIM tablets contain lactose and therefore should not be administered to patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose
Slovenian: Tablete AVAGLIM vsebujejo laktozo, zato bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: The maximum dose is one combined tablet of 8 mg rosiglitazone and 4 mg glimepiride, taken once a day.
Slovenian: Maksimalni odmerek je ena kombinirana tableta 8 mg rosiglitazona in 4 mg glimepirida enkrat na dan.
English: Under the influence of sympatholytic drugs such as betablockers, clonidine, guanethidine and reserpine, the signs of adrenergic counterregulation to hypoglycaemia may be reduced or absent.
Slovenian: Znaki adrenergične protiregulacije na hipoglikemijo se lahko pod vplivom simpatikolitičnih zdravil, npr. zaviralcev beta, klonidina, gvanetidina in reserpina, zmanjšajo ali izginejo.
English: Premenopausal anovulatory women
Slovenian: Ženske pred menopavzo brez ovulacije
English: In a bioequivalence study under fasted conditions, the AUC and Cmax of rosiglitazone and the AUC of glimepiride following a single dose of a 4 mg/4 mg combination tablet were bioequivalent to concomitant administration of rosiglitazone 4 mg and glimepiride 4 mg.
Slovenian: V bioekvivalenčni študiji na tešče sta bila AUC in Cmax rosiglitazona in AUC glimepirida po posamičnem odmerku kombinirane tablete 4 mg/4 mg bioekvivalentna sočasni uporabi 4 mg rosiglitazona in 4 mg glimepirida.
English: The active substances are rosiglitazone and glimepiride.
Slovenian: Zdravilni učinkovini sta rosiglitazon in glimepirid.