FrancophonIA/ELRC3.0 huggingface dataset:
English: - the scope of the referral was the harmonisation of the Summaries of Products Characteristics, labelling and package leaflet.
Danish: - Formålet med indbringelsen af sagen var at harmonisere produktresuméerne, etiketteringen og indlægssedlen.
English: • noises (e.g. hissing, buzzing) in ears
Danish: • lyde (fx hvæsen, summen) i ørerne
English: • if you are taking potassium-sparing medicines, potassium supplements, salt substitutes containing potassium or other medicines that increase the amount of potassium in your blood such as heparin.
Danish: • hvis du tager kaliumbesparende medicin, kaliumtilskud, salttilskud, der indeholder kalium, eller anden medicin, der øger mængden af kalium i dit blod, for eksempel heparin.
English: Patients receiving thiazide diuretics, including hydrochlorothiazide, should be observed for clinical signs of fluid or electrolyte imbalance.
Danish: Patienter, der får thiaziddiuretika, herunder hydrochlorthiazid, skal observeres for kliniske tegn på ændringer i væske- og elektrolytbalancen.
English: • if you have severe heart disease.
Danish: • hvis du har en alvorlig hjertesygdom.
English: The CHMP agreed on including in the harmonised PI interaction of Diovan Comp with: Metformin and iodine contrast agents.
Danish: CHMP besluttede i den harmoniserede produktinformation at medtage følgende, som interagerer med Diovan Comp: Metformin og kontraststoffer, der indeholder jod.
English: These doses in rats (600 mg/kg/day) are approximately 18 times the maximum recommended human dose on a mg/m2 basis (calculations assume an oral dose of 320 mg/day and a 60-kg patient).
Danish: Disse doser hos rotter (600 mg/kg/dag) er cirka 18 gange højere end den maksimale anbefalede humane dosis, udtrykt i mg/m2 (beregningerne forudsætter en oral dosis på 320 mg/dag og en patient på 60 kg).
English: If any of the above apply to you, do not take this medicine and speak to your doctor.
Danish: Hvis noget af dette gælder for dig, skal du fortælle det til din læge, inden du tager denne medicin.
English: Abrupt withdrawal of valsartan has not been associated with rebound hypertension or other adverse clinical events.
Danish: Pludselig seponering af valsartan har ikke resulteret i rebound-hypertension eller andre uønskede kliniske virkninger.
English: Invented name Name
Danish: Særnavn
English: The therapeutic measures depend on the time of ingestion and the type and severity of the symptoms, stabilisation of the circulatory condition being of prime importance.
Danish: De terapeutiske foranstaltninger afhænger af tidspunktet for indtagelse og af symptomernes art og alvor.
English: According with CHMP recommendation, have been included interaction with valsartan and interaction with hydroclortiazide.
Danish: I tråd med CHMP's anbefalinger er oplysninger om interaktion med valsartan og hydrochlorotiazid blevet tilføjet.
English: • anti-cholinergic medicines, such as atropine or biperiden
Danish: • antikolinerge midler, såsom atropin eller biperiden
English: • severely decreased urine output
Danish: • kraftigt nedsat vandladningsmængde
English: The combination also led in the kidney to hyperplasia of the afferent aterioles (at 600 + 188 mg/kg/d in rats and from 30 + 9 mg/kg/d in marmosets).
Danish: I nyrerne medførte kombinationen også hyperplasi i de afferente arterioler (ved 600 + 188 mg/kg/dag hos rotter og fra 30 + 9 mg/kg/dag hos silkeaber).
English: Like many other medicines used to treat high blood pressure, Diovan Comp may occasionally cause dizziness and affect the ability to concentrate.
Danish: Diovan Comp kan, som megen anden medicin mod forhøjet blodtryk, i sjældne tilfælde give svimmelhed og påvirke evnen til at koncentrere sig.
English: − Hypersensitivity to valsartan, hydrochlorothiazide, other sulfonamide-derived medicinal products or to any of the excipients.
Danish: - Overfølsomhed over for valsartan, hydrochlorthiazid, andre sulfonamid-afledte lægemidler eller over for et eller flere af hjælpestofferne.
English: • if you have low levels of potassium in your blood.
Danish: • hvis mængden af kalium i dit blod er lav.
English: • lung infection; breathlessness
Danish: • lungebetændelse; stakåndethed
English: Section 4.8 - Undesirable Effects
Danish: Afsnit 4.8 - Bivirkninger
English: The difference in systolic BP reduction between the 320/25 mg and 320/12.5 mg doses also reached statistical significance.
Danish: Forskellen i systolisk blodtryksreduktion mellem doserne 320/25 mg og 320/12,5 mg opnåede også statistisk signifikans.
English: Thiazide diuretics, including hydrochlorothiazide, have been reported to exacerbate or activate systemic lupus erythematosus.
Danish: Det er rapporteret, at thiaziddiuretika, herunder hydrochlorthiazid, forværrer eller aktiverer systemisk lupus erythematosus.
English: • if you have diabetes, gout, high levels of cholesterol or fats in your blood.
Danish: • hvis du har sukkersyge, urinsyregigt, for højt indhold af kolesterol eller fedt i blodet.
English: Similar findings were seen with valsartan/hydrochlorothiazide in rats and rabbitsIn embryo-fetal development (Segment II) studies with valsartan/hydrochlorothiazide in rat and rabbit, there was no evidence of teratogenicity; however, fetotoxicity associated with maternal toxicity was observed.
Danish: I undersøgelser af den embryoføtale udvikling (segment II) med valsartan/hydrochlorthiazid hos rotter og kaniner var der ingen evidens for teratogenicitet, men der sås dog føtotoksicitet i forbindelse med maternel toksicitet.
English: • cholestyramine and colestipol (medicines used to treat high levels of fats in the blood)
Danish: • colestyramin og colestipol (medicin, der bruges til behandling af forhøjet kolesterol)
English: • carbamazepine, a medicine used to treat seizure conditions
Danish: • carbamazepin, medicin, der bruges til behandling af epilepsianfald
English: • some antibiotics (tetracyclines), anaesthetics and sedatives
Danish: • visse antibiotika (tetracykliner) samt bedøvende og beroligende midler
English: Ear and labyrinth disorders Uncommon
Danish: Øre og labyrint Ikke almindelig
English: Non cardiogenic pulmonary oedema
Danish: Ikke-kardiogent lungeødem
English: • Some antipsychotics (e.g. thioridazine, chlorpromazine, levomepromazine, trifluoperazine,
Danish: • Visse antipsykotika (f.eks. thioridazin, chlorpromazin, levomepromazin, trifluoperazin,
English: • the level of bilirubin increased in blood (which can, in severe cases, trigger yellow skin and eyes)
Danish: • for meget bilirubin i blodet (hvilket i alvorlige tilfælde kan farve hud og det hvide i øjnene gul)
English: Valsartan cannot be eliminated by means of haemodialysis because of its strong plasma binding behaviour whereas clearance of hydrochlorothiazide will be achieved by dialysis.
Danish: Valsartan kan ikke elimineres via hæmodialyse pga. dets stærke plasmabindinggrad, mens clearance af hydrochlorthiazid vil kunne øges ved hæmodialyse.
English: Cholestyramine and cholestipol resins
Danish: Colestyramin- og colestipol-resiner
English: If a medicinal product that affects potassium levels is considered necessary in combination with valsartan, monitoring of potassium plasma levels is advised.
Danish: Hvis samtidig behandling med et lægemiddel, som påvirker kaliumniveauerne, vurderes nødvendig, tilrådes monitorering af plasmakalium.
English: (Calculations assume an oral dose of 320 mg/day valsartan in combination with 25 mg/day hydrochlorothiazide and a 60-kg patient).
Danish: (beregningerne forudsætter en oral dosis på 320 mg/dag valsartan kombineret med 25 mg/dag hydrochlorthiazid og en patient på 60 kg).
English: Ask your pharmacist how to dispose of medicines no longer required.
Danish: • Spørg på apoteket, hvordan du skal aflevere medicinrester.
English: • the level of blood urea nitrogen and creatinine increased in blood (which can indicate abnormal kidney function)
Danish: • for meget blodureanitrogen og kreatinin i blodet (hvilket kan være tegn på unormal nyrefunktion)
English: − Second and third trimester of pregnancy (section 4.4 and 4.6).
Danish: - Andet og tredje trimester i graviditeten (se pkt.
English: The data from the two factorial trials and the “Guidance on Clinical Investigation of Medicinal Products in the treatment of hypertension” support the direct change from monotherapy to the fixed combination of 160/25 mg or 320/12.5-25 mg in patients whose blood pressure is not adequately controlled on either valsartan or hydrochlorothiazide monotherapy.
Danish: Data fra de to faktorielle undersøgelser og vejledningen om klinisk undersøgelse af lægemidler i forbindelse med behandling af hypertension ("Guidance on Clinical Investigation of Medicinal Products in the treatment of hypertension") understøtter det direkte skift fra monoterapi til den faste kombination af 160/25 mg eller 320/12,5-25 mg hos patienter, hvis blodtryk ikke kan kontrolleres tilfredsstillende ved hjælp af valsartan eller hydrochlorothiazid monoterapi.
English: If this applies to you, the use of Diovan Comp is not recommended.
Danish: Hvis dette gælder for dig, frarådes det, at du tager Diovan
English: Elevation of liver function values
Danish: Forhøjede leverfunktionstal
English: • Class Ia antiarrhythmics (e.g. quinidine, hydroquinidine, disopyramide)
Danish: • Klasse Ia antiarytmika (f.eks. quinidin, hydroquinidin, disopyramid)
English: • inflammation of blood vessels with symptoms such as rash, purplish-red spots, fever
Danish: • betændelse i blodkar med symptomer såsom udslæt, purpurrøde pletter, feber
English: • dehydration (with symptoms of thirst, dry mouth and tongue, infrequent urination, dark colored urine, dry skin)
Danish: • dehydrering (med symptomer som tørst, tør mund og tunge, sjældne vandladninger, mørk urin,
English: Loss of appetite, mild nausea and vomiting
Danish: Appetitløshed, let kvalme og opkastning
English: There is no data available on the use of valsartan in patients with severe hepatic dysfunction (see section 4.3).
Danish: Der findes ingen tilgængelige data for anvendelse af valsartan til patienter med alvorlig leverinsufficiens (se pkt.
English: Hydrochlorothiazide is excreted in human milk.
Danish: Hydrochlorthiazid udskilles i modermælken.
English: was reduced (p <0.001) by 42% (-24.2 µg/min; 95% CI: -40.4 to -19.1) with valsartan and approximately 3% (-1.7 µg/min; 95% CI: -5.6 to 14.9) with amlodipine despite similar rates of blood pressure reduction in both groups.
Danish: Efter 24 uger var UAE reduceret (p<0,001) med 42 % (-24,2 µg/min; 95 % konfidensinterval: -40,4 til -19,1) med valsartan og cirka 3 % (-1,7 µg/min; 95 % konfidensinterval: -5,6 til 14,9) med amlodipin trods ensartet reduktion af blodtryksværdierne i begge grupper.
English: • Tell your doctor if you are breast-feeding or about to start breast-feeding Diovan Comp is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Danish: Diovan Comp frarådes til mødre, der ammer, og din læge kan vælge en anden behandling, hvis du gerne vil amme, især hvis dit barn er nyfødt eller er født for tidligt.
English: Cytotoxic agents (e.g. cyclophosamide, methotrexate) Thiazides, including hydrochlorothiazide, may reduce renal excretion of cytotoxic agents and potentiate their myelosuppressive effects.
Danish: Cytotoksiske midler (f.eks. cyclophosphamid, methotrexat) Thiazider, herunder hydrochlorthiazid, kan nedsætte den renale ekskretion af cytotoksiske midler og forstærke deres myelosuppressive virkning.
English: Diovan Comp may increase the effects of other agents with antihypertensive properties (e.g. ACEI, beta blockers, calcium channel blockers).
Danish: Diovan Comp kan øge effekten af andre præparater med antihypertensiv effekt (f.eks. ACE-hæmmere, betablokkere, calciumantagonister).
English: Angioedema, rash, pruritus
Danish: Angioødem, udslæt, pruritus
English: Thiazide diuretics, including hydrochlorothiazide, may alter glucose tolerance and raise serum levels of cholesterol, triglycerides and uric acid.
Danish: Thiaziddiuretika, herunder hydrochlorthiazid, kan ændre glucosetolerancen og forhøje serumværdier af cholesterol, triglycerider og urinsyre.
English: No dose adjustment is required for patients with mild to moderate renal impairment (creatinine clearance ≥30 ml/min).
Danish: Der kræves ingen dosisjustering for patienter med let til moderat nedsat nyrefunktion (kreatininclearance ≥30 ml/min).
English: • low level of sodium in the blood (sometimes with nausea, tiredness, confusion, malaise,
Danish: • lavt natriumindhold i blodet (undertiden med kvalme, træthed, forvirring, utilpashed, kramper)
English: Respiratory, thoracic and mediastinal disorders Very rare
Danish: Luftveje, thorax og mediastinum Meget sjælden
English: Netherlands Novartis Pharma B.V. Raapopseweg 1 Postbus 241 NL-6824 DP Arnhem
Danish: Raapopseweg 1 Postbus 241 NL-6824 DP Arnhem
English: Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels
Danish: Kaliumbesparende diuretika, kaliumtilskud, salterstatninger indeholdende kalium og andre stoffer, der kan forhøje kaliumniveauerne
English: In marmosets, damage was observed in the gastric mucosa (from 30 + 9 mg/kg/d).
Danish: Hos silkeaber sås der skader i maveslimhinden (fra 30 + 9 mg/kg/dag).
English: Reversible increases in serum lithium concentrations and toxicity have been reported during concurrent use of ACE inhibitors and thiazide, including hydrochlorothiazide.
Danish: Reversible forhøjelser af serumlithiumkoncentrationer og toksicitet er blevet rapporteret ved samtidig brug af ACE-hæmmere og thiazider, herunder hydrochlorthiazid.
English: • it may cause increased sensitivity of the skin to sun.
Danish: • Diovan Comp kan forårsage, at hudens følsomhed over for sol øges.
English: The CHMP adopted the following: “Diovan Comp fixed dose-combination is indicated in patients whose blood pressure is not adequately controlled on valsartan or hydrochlorotiazide monotherapy”
Danish: CHMP vedtog følgende: "Diovan Comp fastdosiskombination er indiceret til patienter, hvis blodtryk ikke kan kontrolleres tilfredsstillende ved hjælp af valsartan eller hydrochlorothiazid monoterapi".
English: In a clinical trial of patients with a history of dry cough during ACE inhibitor therapy, 19.5% of trial subjects receiving valsartan and 19.0% of those receiving a thiazide diuretic experienced cough compared to 68.5% of those treated with an ACE inhibitor (P <0.05).
Danish: I en klinisk undersøgelse med patienter, som tidligere havde haft tør hoste under behandling med en ACE-hæmmer, konstateredes tør hoste hos 19,5 % af patienterne i valsartanbehandling, hos 19,0 % i thiazidbehandling, sammenholdt med 68,5 % i behandling med en ACE-hæmmer (P < 0,05).
English: If you forget to take Diovan Comp
Danish: Hvis du har glemt at tage Diovan Comp
English: • spinning sensation
Danish: • snurrende følelse
English: • medicines that may increase the amount of potassium in your blood, such as potassium supplements, potassium-containing salt substitutes, potassium-sparing medicines, heparin
Danish: • medicin, der kan øge mængden af kalium i blodet, såsom kaliumtilskud, kaliumholdige salterstatninger, kaliumbesparende medicin, heparin
English: Lithuania Novartis Finland Oy Metsänneidonkuja 10
Danish: Litauen Novartis Finland Oy Metsänneidonkuja 10
English: • allergic reactions (with symptoms such as rash, itching, hives, difficulty breathing or swallowing, dizziness)
Danish: • allergiske reaktioner (med symptomer såsom udslæt, kløe, nældefeber, vejrtrækningsbesvær eller synkebesvær, svimmelhed)
English: Psychiatric disorders Rare
Danish: Psykiske forstyrrelser Sjælden
English: At 30 weeks, the percentage change in UAE was significantly reduced by 36% from baseline with valsartan 160 mg (95%CI: 22 to 47%), and by 44% with valsartan 320 mg (95%CI: 31 to 54%).
Danish: Efter 30 uger var den procentvise ændring af UAE signifikant reduceret med 36 % i forhold til baseline med valsartan 160 mg (95 % konfidensinterval: 22 til 47 %) og med 44 % med valsartan 320 mg
English: Renal clearance of hydrochlorothiazide is composed of passive filtration and active secretion into the renal tubule.
Danish: Renal clearance består for hydrochlorthiazids vedkommende af passiv filtration og aktiv udskillelse i de renale tubuli.
English: When clinically appropriate direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled on valsartan or hydrochlorothiazide monotherapy, provided the recommended dose titration sequence for the individual components is followed.
Danish: Hvis klinisk relevant kan direkte skift fra monoterapi til den faste dosiskombination overvejes til patienter, hvis blodtryk ikke er tilstrækkeligt kontrolleret med valsartan eller hydrochlortiazid som monoterapi under forudsætning af, at den anbefalede dosistitreringssekvens for hver enkelt komponent følges.
English: Agranulocytosis, leucopenia, haemolytic anaemia, bone marrow depression
Danish: Agranulocytose, leukopeni, hæmolytisk anæmi, knoglemarvsdepression
English: Hypokalaemia has been reported under treatment with thiazide diuretics, including hydrochlorothiazide.
Danish: Der er rapporteret hypokaliæmi ved behandling med thiaziddiuretika, herunder hydrochlorthiazid.
English: Decrease in haemoglobin, decrease in haematocrit, thrombocytopenia
Danish: Fald i hæmoglobin, fald i hæmatokrit, trombocytopeni
English: • hives and difficulties in breathing
Danish: • kløende udslæt og svært ved at trække vejret
English: General disorders and administration site conditions Uncommon
Danish: Almene symptomer og reaktioner på administrationsstedet Ikke almindelig
English: The Diovan Reduction of Proteinuria (DROP) study further examined the efficacy of valsartan in reducing UAE in 391 hypertensive patients (BP=150/88 mmHg) with type 2 diabetes, albuminuria (mean=102 µg/min; 20-700 µg/min) and preserved renal function (mean serum creatinine = 80 µmol/l).
Danish: DROP (Diovan Reduction of Proteinuria)-undersøgelsen undersøgte yderligere effektiviteten af valsartan mht. reduktion af UAE hos 391 hypertensive patienter (BT=150/88 mmHg) med type 2 diabetes, albuminuri (gennemsnit=102 µg/min; 20-700 µg/min) og bevaret nyrefunktion (gennemsnitlig serumkreatinin = 80 µmol/l).
English: The MARVAL (Micro Albuminuria Reduction with Valsartan) study assessed the reduction in urinary albumin excretion (UAE) with valsartan (80-160 mg/od) versus amlodipine (5-10 mg/od), in 332 type 2 diabetic patients (mean age: 58 years; 265 men) with microalbuminuria (valsartan: 58 µg/min; amlodipine: 55.4 µg/min), normal or high blood pressure and with preserved renal function (blood creatinine <120 µmol/l).
Danish: MARVAL (Micro Albuminuria Reduction with Valsartan)undersøgelsen vurderede reduktionen i udskillelse af albumin via urinen (UAE) med valsartan (80-160 mg 1 gang daglig) versus amlodipin (5-10 mg 1 gang daglig ), hos 332 type 2 diabetespatienter (gennemsnitsalder: 58 år; 265 mænd) med mikroalbuminuri (valsartan: 58 µg/min; amlodipin: 55,4 µg/min) og normalt eller højt blodtryk og med bevaret nyrefunktion (blodkreatinin <120 µmol/l).
English: The recommended dose of Diovan Comp X mg/Y mg is one film-coated tablet once daily.
Danish: Den anbefalede dosis Diovan Comp X mg/Y mg er én filmovertrukken tablet daglig.
English: • rash, purplished-red spots, fever, itching (symptoms of inflammation of blood vessels)
Danish: • udslæt, purpurfarvede pletter, feber, kløe (symptomer på betændelse i blodkar)
English: Absorption of thiazide diuretics, including hydrochlorothiazide, is impaired in the presence of anionic exchange resins.
Danish: Absorption af thiazider, herunder hydrochlorthiazid, nedsættes i tilstedeværelse af anionbytterresiner.
English: Treatment with thiazide diuretics, including hydrochlorothiazide, has been associated with hyponatraemia and hypochloraemic alkalosis.
Danish: Behandling med thiaziddiuretika, herunder hydrochlorthiazid, er sat i forbindelse med hyponatriæmi og hypochloræmisk alkalose.
English: • syncope (fainting)
Danish: • synkope (følelse af at være ved at besvime)
English: Before you drive a vehicle, use tools or operate machines or carry out other activities that require concentration, make sure you know how Diovan Comp affects you.
Danish: Du skal være sikker på, hvordan Diovan Comp påvirker dig, før du kører bil, bruger værktøj eller betjener maskiner eller udfører andre aktiviteter, der kræver koncentration.
English: The CHMP agreed including the ADR Renal failure as listed in the SPC of Diovan.
Danish: CHMP besluttede at medtage bivirkningen nyresvigt som nævnt i produktresuméet for Diovan.
English: High doses of the valsartan - hydrochlorothiazide combination caused falls in red blood cell indices (red cell count, haemoglobin, haematocrit, from 100 + 31 mg/kg/d in rats and 30 + 9 mg/kg/d in marmosets).
Danish: Høje doser af valsartan-hydrochlorthiazidkombinationen medførte et fald i blodtal (erytrocytter, hæmoglobin, hæmatokrit, fra 100 + 31 mg/kg/dag hos rotter og 30 + 9 mg/kg/dag hos silkeaber).
English: Thiazides, including hydrochlorothiazide, increase the urinary excretion of magnesium, which may result in hypomagnesaemia.
Danish: Thiazider, herunder hydrochlorthiazid, øger urinudskillelsen af magnesium, hvilket kan medføre hypomagnesiæmi.
English: • low level of blood platelets (sometimes with unusual bleeding or bruising)
Danish: • lavt antal blodplader (undertiden med usædvanlige blødninger eller blå mærker)
English: Immune system disorders Very rare
Danish: Immunsystemet Meget sjælden
English: - the Summaries of Products Characteristic, labelling and package leaflet proposed by the Marketing Authorisation Holders has been assessed based on the documentation submitted and the scientific discussion within the Committee,
Danish: - Produktresuméerne, etiketteringen og indlægssedlen, som indehaveren af markedsføringstilladelsen har foreslået, er blevet vurderet på baggrund af den indsendte dokumentation og den faglige drøftelse i udvalget anbefaler CHMP ændring af markedsføringstilladelsen for Diovan Comp og tilknyttede navne (se bilag I).
English: • constipation, discomfort of the stomach or bowels, liver disorders (yellow skin or eyes)
Danish: • forstoppelse, mave- og tarmbesvær, leversygdomme (gulfarvning af hud eller det hvide i øjnene)
English: • if you have liver or kidney disease.
Danish: • hvis du har en lever- eller nyresygdom.
English: • low level of blood platelets (sometimes with bleeding or bruising underneath the skin)
Danish: • lavt antal blodplader (undertiden med blødninger eller blå mærker under huden)
English: Cases of photosensitivity reactions have been reported with thiazide diuretics (see section 4.8).
Danish: Der er rapporteret lysfølsomhedsreaktioner med thiaziddiuretika (se pkt.
English: Interactions related to both valsartan and hydrochlorothiazide
Danish: Interaktioner relateret til både valsartan og hydrochlorthiazid
English: The increased plasma levels of Ang II following AT1 receptor blockade with valsartan may stimulate the unblocked AT2 receptor, which appears to counterbalance the effect of the AT1 receptor.
Danish: Dette kan stimulere den ublokerede AT2-receptor-subtype, som tilsyneladende modvirker effekten af AT1-receptoren.
English: Novartis Pharma S.A.S.
Danish: Frankrig Novartis Pharma S.A.S.
English: No dosage adjustment is required for patients with renal impairment with a creatinine clearance ≥30 ml/min (see section 4.2).
Danish: Der kræves ingen dosisjustering hos patienter med nedsat nyrefunktion med en kreatininclearance ≥30 ml/min (se pkt.
English: The combination is useful in patients whose blood pressure is not adequately controlled by valsartan monotherapy.
Danish: Denne kombination er hensigtsmæssig til patienter, hvis blodtryk ikke kan kontrolleres tilfredsstillende ved hjælp af valsartan som monoterapi.
English: Non-depolarising skeletal muscle relaxants (e.g. tubocurarine) Thiazides, including hydrochlorothiazide, potentiate the action of curare derivatives.
Danish: Ikke-depolariserende muskelrelaxantia (f.eks. tubocurarin) Thiazider, herunder hydrochlorthiazid, forstærker virkningen af curarederivater.