FrancophonIA/ELRC3.0 huggingface dataset:
English: The pharmacokinetics of A771726 following oral administration of leflunomide have been investigated in 73 pediatric patients with polyarticular course Juvenile Rheumatoid Arthritis (JRA) who ranged in age from 3 to 17 years.
Croatian: Farmakokinetika A771726 nakon oralne primjene leflunomida ispitivana je u 73 pedijatrijska bolesnika u dobi od 3 do 17 godina s poliartikuliranim oblikom juvenilnog reumatoidnog artritisa
English: At a dose level of 20 mg/day, average plasma concentration of A771726 at steady state is approximately 35 μg/ml.
Croatian: Pri dozi od 20 mg/dan prosječna koncentracija A771726 u plazmi u stanju dinamičke ravnoteže iznosila je oko 35 μg/ml.
English: Each tablet contains 194.5 mg of lactose monohydrate and 6.25 mg anhydrous lactose.
Croatian: Jedna tableta sadrži 194,5 mg laktoze hidrata i 6,25 mg laktoze, bezvodne.
English: In vivo, it is rapidly and almost completely metabolised to A771726 which is active in vitro, and is presumed to be responsible for the therapeutic effect.
Croatian: In vivo se brzo i gotovo potpuno metabolizira u A771726, koji je aktivan in vitro te se smatra
English: - If you have bone marrow problems, or if you have low numbers of red or white blood cells or a reduced number of blood platelets, due to causes other than rheumatoid or psoriatic arthritis.
Croatian: Ako imate problema s koštanom srži ili ako imate smanjen broj crvenih ili bijelih krvnih stanica ili krvnih pločica (trombocita) koji nije uzrokovan reumatoidnim ili psorijatičnim artritisom.
English: If you are pregnant or become pregnant while taking Leflunomide Teva, the risk of having a baby with serious
Croatian: Ako ste trudni ili zatrudnite dok uzimate Leflunomid Teva, rizik od ozbiljnih prirođenih mana u Vašeg djeteta
English: - An increase in some liver test results.
Croatian: - porast vrijednosti određenih jetrenih enzima;
English: If both plasma concentrations are below 0.02 mg/l, and after a waiting period of at least 3 months, the risk of
Croatian: Ako je u oba slučaja koncentracija u plazmi manja od 0,02 mg/l, a nakon stanke od najmanje 3 mjeseca, rizik od fetalne
English: Interstitial lung disease is a potentially fatal disorder, which may occur acutely during therapy.
Croatian: Intersticijska plućna bolest može imati smrtni ishod, a smrt može nastupiti iznenada tijekom liječenja
English: In patients with pre-existing anaemia, leucopenia, and/or thrombocytopenia as well as in patients with impaired bone marrow function or those at risk of bone marrow suppression, the risk of haematological disorders is increased.
Croatian: U bolesnika s postojećom anemijom, leukopenijom i/ili trombocitopenijom, kao i u bolesnika s oštećenom funkcijom koštane srži ili s rizikom od supresije koštane srži, povećan je rizik od pojave hematoloških poremećaja.
English: Not known side effects (frequency cannot be estimated from the available data): - Kidney failure.
Croatian: Nepoznate nuspojave (učestalost se ne može procijeniti na osnovi raspoloživih podataka): zatajenje bubrega;
English: For washout procedures and other recommended actions in case of desired or unintended pregnancy
Croatian: Za ispiranje ("washout" postupak) i ostale preporučene aktivnosti u slučaju željene ili neplanirane trudnoće vidjeti dio 4.6.
English: Cases of peripheral neuropathy have been reported in patients receiving Leflunomide Teva.
Croatian: Slučajevi periferne neuropatije zabilježeni su u bolesnika koji su uzimali Leflunomid Teva.
English: If such effects occur, a washout (see below) to reduce plasma levels of A771726 should be considered.
Croatian: Ako se ti učinci pojave, treba razmotriti postupak eliminacije (vidjeti nastavak teksta) kako bi se smanjila koncentracija A771726 u plazmi.
English: The ACR (American College of Rheumatology) response rates in study YU203 were 27.7 % for placebo, 31.9 % for 5 mg, 50.5 % for 10 mg and
Croatian: Stope terapijskog odgovora prema ACR-u (American College of Rheumatology) u studiji YU203 bile su 27,7% za placebo, 31,9% za 5 mg/dan, 50,5% za 10 mg/dan i 54,5% za 25 mg/dan.
English: If a waiting period of up to approximately 2 years under reliable contraception is considered unpractical, prophylactic institution of a washout procedure may be advisable.
Croatian: Ako nije moguće čekati dvije godine uz odgovarajuću kontracepciju, preporučuje se profilaktički započeti ispiranje ("washout" postupak).
English: In vitro plasma protein binding interaction studies with warfarin at clinically relevant concentrations, however, showed no interaction.
Croatian: U in vitro ispitivanjima interakcija s varfarinom kod vezanja za proteine plazme nisu zabilježene interakcije pri klinički relevantnim koncentracijama.
English: Colestyramine given orally at a dose of 8 g three times a day for 24 hours to three healthy volunteers decreased plasma levels of A771726 by approximately 40 % in 24 hours and by 49 % to
Croatian: Kolestiramin u dozi od 8 g primijenjen oralno tri puta tijekom 24 sata u tri zdrava dobrovoljca smanjio je koncentraciju A771726 u plazmi za oko 40% u 24 sata, te za 49% do 65% u 48 sati.
English: In a study in which leflunomide was given concomitantly with a triphasic oral contraceptive pill containing 30 μg ethinyloestradiol to healthy female volunteers, there was no reduction in contraceptive activity of the pill, and A771726 pharmacokinetics were within predicted ranges.
Croatian: U ispitivanju u kojem se zdravim ženama leflunomid davao istodobno s trifaznim oralnim kontraceptivima koji su sadržavali 30 μg etiniloestradiola nije zabilježena smanjena kontracepcijska aktivnost pilule, dok je farmakokinetika A771726 bila u predvidljivim rasponima.
English: In the event that severe, uncontrolled infections occur, it may be necessary to interrupt leflunomide treatment and administer a washout procedure as described below.
Croatian: U slučaju pojave teških nekontroliranih infekcija može biti potrebno prekinuti primjenu leflunomida i započeti eliminaciju, kako je opisano u nastavku teksta.
English: • colestyramine 8 g is administered 3 times daily for a period of 11 days,
Croatian: • kolestiramin 8 g tri puta na dan tijekom 11 dana,
English: In multiple dose studies in patients with rheumatoid arthritis, the pharmacokinetic parameters of A771726 were linear over the dose range of 5 to 25 mg.
Croatian: U ispitivanjima višekratnih doza u bolesnika s reumatoidnim artritisom, farmakokinetički parametri A771726 bili su linearni u rasponu doza od 5 do 25 mg.
English: It is recommended that patients receiving leflunomide are not treated with colestyramine or activated powdered charcoal because this leads to a rapid and significant decrease in plasma A771726 (the active metabolite of leflunomide; see also section 5) concentration.
Croatian: Preporučuje se da se bolesnici koji uzimaju leflunomid ne liječe kolestiraminom ili aktivnim ugljenom u prahu jer oni utječu na brzo i značajno smanjenje koncentracije A771726 (aktivnog metabolita leflunomida; vidjeti dio 5) u plazmi.
English: Moreover, switching from leflunomide to another DMARD without following the washout procedure (see section 4.4) may also increase the risk of serious adverse reactions even for a long time after the
Croatian: Osim toga, prijelaz s leflunomida na neki drugi DMARD, bez provedbe ispiranja ("washout" postupak) leflunomida (vidjeti dio 4.4.), također može povećati rizik od ozbiljnih nuspojava, čak i
English: - If you already have low red or white blood cells (anaemia or leucopenia), low blood platelets, which may increase your bleeding or bruising (thrombocytopenia), low bone marrow function or if you are at risk of your bone marrow not working properly your doctor may advise you to take certain medicines to speed up the removal of Leflunomide Teva from your body.
Croatian: Ako već imate niske razine crvenih ili bijelih krvnih stanica (anemiju ili leukopeniju), niske razine trombocita, što može povećati rizik od krvarenja ili pojave modrica (trombocitopenija), odnosno ako imate smanjenu funkciju koštane srži ili ako postoji rizik od oštećenja funkcije koštane srži, liječnik Vam može savjetovati uzimanje određenih lijekova koji će ubrzati uklanjanje Leflunomida Teva iz tijela.
English: Marketing Authorisation Holder: Teva Pharma B.V.
Croatian: NOSITELJ ODOBRENJA ZA STAVLJANJE GOTOVOG LIJEKA U PROMET Teva Pharma B.V.
English: Leflunomide is metabolised to one primary (A771726) and many minor metabolites including TFMA (4-trifluoromethylaniline).
Croatian: Leflunomid se metabolizira u jedan glavni (A771726) i više manjih metabolita, uključujući (4-trifluorometilanilin).
English: This is thought to be achieved by a gastrointestinal dialysis mechanism and/or by interrupting enterohepatic recycling.
Croatian: Smatra se da se taj učinak postiže gastrointestinalnom dijalizom i/ili prekidom
English: No clinical data are available on the efficacy and safety of vaccinations under leflunomide treatment.
Croatian: Ne postoje klinički podaci o djelotvornosti i sigurnosti cijepljenja u osoba koje se istodobno liječe leflunomidom.
English: • The identified risk of synergistic hepato- or haematotoxicity associated with combination therapy with another Disease-Modifying Antirheumatic Drug (e.g. methotrexate).
Croatian: • Prepoznat rizik od sinergije između hepatotoksičnosti ili hematotoksičnosti i kombinirane terapije s nekim drugim antireumatikom koji modificira tijek bolesti (primjerice
English: In a small (n=30) study with co-administration of leflunomide (10 to 20 mg per day) with methotrexate (10 to 25 mg per week) a 2- to 3-fold elevation in liver enzymes was seen on 5 of 30 patients.
Croatian: U manjem ispitivanju (n=30) istodobne primjene leflunomida (10 do 20 mg na dan) i metotreksata (10 do 25 mg na tjedan) opaženo je povišenje jetrenih enzima dva do tri puta u 5 od 30 bolesnika.
English: HDPE containers: Do not store above 30°C.
Croatian: HDPE spremnici: Ne čuvati na temperaturi iznad 30°C.
English: Do not use this medicine after the expiry date that is stated on the outer carton or foil after EXP.
Croatian: Ovaj lijek ne smije se upotrijebiti nakon isteka roka valjanosti navedenog na vanjskom pakovanju ili foliji iza oznake „Rok valjanosti ili kratice „EXP“.
English: - Severe sometimes life-threatening reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme).
Croatian: - teške reakcije koje ponekad mogu biti opasne po život (Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, multiformni eritem);
English: • alternatively, 50 g of activated powdered charcoal is administered 4 times daily for a period
Croatian: • alternativno, 50 g aktivnog ugljena u prahu četiri puta na dan tijekom 11 dana.
English: Caution is advised when leflunomide is given together with drugs, other than NSAIDs, metabolised by CYP2C9 such as phenytoin, warfarin, phenprocoumon and tolbutamide.
Croatian: Oprez je potreban kad se leflunomid daje zajedno s ostalim lijekovima, osim nesteroidnih protuupalnih lijekova, koji se metaboliziraju pomoću CYP2C9, poput fenitoina, varfarina, fenprokumona i tolbutamida.
English: Very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare
Croatian: Vrlo često (≥ 1/10), često (≥ 1/100 do < 1/10), manje često (≥ 1/1000 do <1/100), rijetko (≥ 1/10000 do <1/1000), vrlo rijetko (<1/10000), nepoznato (nije moguće procijeniti iz dostupnih podataka).
English: Leflunomide is indicated for the treatment of adult patients with active rheumatoid arthritis as a "disease modifying antirheumatic drug" (DMARD).
Croatian: Leflunomid je indiciran u liječenju odraslih bolesnika s aktivnim reumatoidnim artritisom kao antireumatik koji modificira tijek bolesti (DMARD od engl. disease-modifying antirheumatic drug).
English: - If you suffer from moderate to severe kidney problems.
Croatian: Ako imate umjerene do teške probleme s bubrezima.
English: Thereafter, the A771726 plasma concentration must be determined again after an interval of at least 14 days.
Croatian: Nakon toga, koncentracija A771726 u plazmi mora se ponovo utvrditi nakon intervala od najmanje 14 dana.
English: - Colestyramine (used to lower cholesterol levels and treat itching associated with jaundice) or activated charcoal as these medicines can reduce the amount of LeflunomideTeva absorbed by your body.
Croatian: - Kolestiramin (primjenjuje se za snižavanje razine kolesterola i liječenje svrbeža povezanog sa žuticom) ili aktivni ugljen jer ti lijekovi mogu smanjiti količinu Leflunomida Teva koju
English: It has been shown in man that administration of an oral suspension of activated powdered charcoal or colestyramine leads to a rapid and significant increase in A771726 elimination rate and decline in plasma concentrations (see section 4.9).
Croatian: Zabilježeno je da peroralna primjena suspenzije aktivnog ugljika ili kolestiramina u ljudi ubrzava i značajno povećava stupanj eliminacije A771726 i smanjuje njegovu koncentraciju u plazmi (vidjeti dio 4.9.).
English: Interstitial lung disease has been reported during treatment with leflunomide (see section 4.8).
Croatian: Za vrijeme liječenja leflunomidom zabilježena je intersticijska plućna bolest (vidjeti dio 4.8).
English: If a patient taking Leflunomide Teva develops a peripheral neuropathy, consider discontinuing Leflunomide Teva therapy and performing the drug elimination
Croatian: Ako se u bolesnika koji uzima Leflunomid Teva pojavi periferna neuropatija, treba razmotriti prestanak terapije
English: - If you develop a skin rash or ulcers in your mouth, as these may indicate severe, sometimes life-threatening reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema
Croatian: - Ako dobijete kožni osip ili čireve u ustima jer to može upućivati na teške reakcije, ponekad opasne po život (npr. Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, multiformni
English: The initial period was followed by an open label maintenance period of three months, during which both groups received leflunomide 20 mg daily.
Croatian: Nakon početnog razdoblja uslijedilo je otvoreno ispitivanje doze održavanja u trajanju od tri mjeseca, tijekom kojeg su obje skupine dobivale luflonomid u dozi od 20 mg na dan.
English: Leflunomide Teva stored in bottles are available in pack sizes of 30 and 100 film-coated tablets.
Croatian: Leflunomid Teva u bočicama je dostupan u veličinama pakovanja od 30 i 100 filmom obloženih
English: Due to the very long half-lifeof A771726 (approximately 2 weeks), a loading dose of 100 mg for 3 days was used in clinical studies to facilitate the rapid attainment of steady-state levels of A771726.
Croatian: Zbog veoma dugog poluvijeka A771726 (oko 2 tjedna), u kliničkim je ispitivanjima primjenjivana udarna doza od 100 mg tijekom 3 dana kako bi se ubrzalo postizanje stanja dinamičke ravnoteže A771726.
English: C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING
Croatian: OSTALI UVJETI I ZAHTJEVI ZA STAVLJANJE GOTOVOG
English: The Marketing Authorisation Holder (MAH) shall ensure that all physicians who are expected to prescribe/use Leflunomide Teva are provided with a physician educational pack containing the
Croatian: Nositelj odobrenja za stavljanje gotovog lijeka u promet dužan je osigurati da svi liječnici koji bi mogli propisivati/upotrebljavati Leflunomid Teva dobiju edukacijski komplet za liječnike koji
English: The patient must be advised that if there is any delay in onset of menses or any other reason to suspect pregnancy, they must notify the physician immediately for pregnancy testing, and if positive, the physician and patient must discuss the risk to the pregnancy.
Croatian: Bolesnice treba savjetovati da u slučaju kašnjenja menstruacije ili sumnje na trudnoću odmah obavijeste liječnika zbog provođenja testa na trudnoću.
English: • Within 60 days of an important (pharmacovigilance or risk minimisation) milestone being
Croatian: Farmakovigilancijski plan ili aktivnosti smanjenja rizika • U roku od 60 dana od novih važnih saznanja (farmakovigilancijskih ili u sklopu minimalizacije
English: Because you may get increased side effects, it is not recommended to take any of these medicines while you are taking Leflunomide Teva.
Croatian: Budući da se nuspojave mogu pogoršati, ne preporučuje se istodobna primjena tih lijekova i Leflunomida Teva.
English: A771726, the active metabolite of leflunomide, inhibits the human enzyme dihydroorotate dehydrogenase (DHODH) and exhibits antiproliferative activity.
Croatian: A771726, aktivni metabolit leflunomida, inhibira humani enzim dihidroorotat dehidrogenazu
English: If you are pregnant, your doctor will discuss with you the risks to the pregnancy.
Croatian: Ako je test pozitivan, liječnik mora razgovarati s bolesnicom o riziku za trudnoću.
English: As soon as skin and/or mucosal reactions are observed which raise the suspicion of such severe reactions, Leflunomide Teva and any other possibly associated treatment must be discontinued, and a leflunomide washout procedure initiated immediately.
Croatian: Čim se pojave reakcije na koži i/ili sluznici koje izazivaju sumnju na teške nuspojave, uzimanje Leflunomida Teva ili bilo kojeg dodatnog lijeka treba prekinuti i odmah započeti postupak eliminacije leflunomida.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON/BLISTER PACK
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU VANJSKA KARTONSKA KUTIJA/BLISTER
English: All leflunomide patients in the phase III trials used an initial dose of 100 mg for 3 days.
Croatian: Svi bolesnici koji su uzimali leflunomid u ispitivanjima faze III počeli su s dozom od 100 mg tijekom tri dana.
English: - Low blood levels of potassium which can cause muscle weakness, twitching or abnormal heart - An increase in the levels of fat in the blood (cholesterol and triglycerides).
Croatian: - smanjenje koncentracije kalija u krvi, što može uzrokovati mišićnu slabost, mišićne kontrakcije ili - povećanje razine masnoća u krvi (kolesterol i trigliceridi);
English: An in vivo interaction study with cimetidine (non-specific cytochrome P450 inhibitor) has demonstrated a lack of a significant interaction.
Croatian: U in vivo ispitivanjima interakcija s cimetidinom (nespecifičnim inhibitorom citokroma P450) nisu opažene značajne interakcije.
English: Consistent with extensive protein binding A771726 has a low apparent volume of distribution (approximately 11 litres).
Croatian: A771726 ima mali prividni volumen distribucije (oko 11 litara).
English: - If you develop swollen spongy gums, ulcers, and loose teeth (an infectious mouth disease known as ulcerative stomatitis) then you should contact your doctor who may advise you to stop
Croatian: - Ako Vam otiču desni, imate čireve u usnoj šupljini ili gubite zube (odnosno imate infekciju usne šupljine koja se zove ulcerozni stomatitis), morate se javiti svom liječniku koji će Vam možda savjetovati da prestanete uzimati Leflunomid Teva.
English: - Inflammation of the small vessels (vasculitis, including cutaneous necrotizing vasculitis).
Croatian: - upala malih krvnih žila (vaskulitis, uključujući kožni nekrotizirajući vaskulitis);
English: - Severe infections (including sepsis), which may be fatal.
Croatian: teške infekcije, uključujući sepsu koja može biti smrtonosna
English: Pulmonary symptoms, such as cough and dyspnoea, may be a reason for discontinuation of the therapy and for further investigation, as appropriate.
Croatian: Plućni simptomi, kao što su kašalj i dispneja, mogu biti razlogom za prekid liječenja i provođenje
English: Leflunomide Teva is used to treat adult patients with active rheumatoid arthritis.
Croatian: Leflunomid Teva primjenjuje se za liječenje odraslih bolesnika s aktivnim oblikom reumatoidnog
English: ratiopharm Oy Sími: +358 20 180 5900
Croatian: Ísland ratiopharm Oy Sími: +358 20 180 5900
English: - Yellowing of the skin or whites of the eyes caused by liver or blood problems (jaundice).
Croatian: - žuta boja kože ili bjeloočnica, koja je posljedica poremećaja jetre ili krvi (žutica).
English: Tell your doctor immediately if you experience: - Pale skin, tiredness, or bruising, as these may indicate blood disorders caused by an imbalance in the different types of blood cells which make up blood.
Croatian: - Bljedoće kože, umora ili pojave modrica jer to može upućivati na krvne poremećaje uzrokovane poremećenom ravnotežom različitih vrsta krvnih stanica.
English: HDPE tablet container with polypropylene screw cap.
Croatian: HDPE spremnik za tablete s polipropilenskim čepom s navojem.
English: The use of leflunomide with antimalarials used in rheumatic diseases (e.g. chloroquine and hydroxychloroquine), intramuscular or oral gold, D-penicillamine, azathioprine and other immunosuppressive agents including Tumour Necrosis Factor alpha-Inhibitors has not been adequately studied up to now in randomised trials (with the exception of methotrexate, see section 4.5).
Croatian: Do sada u randomiziranim ispitivanjima nije ispitivana primjena leflunomida s antimalaricima koji se koriste za reumatske bolesti (npr. klorokin i hidroksiklorokin), intramuskularno ili peroralno primijenjenim solima zlata, D-penicilaminom, azatioprinom te ostalim imunosupresivnim lijekovima uključujući inhibitore faktora nekroze tumora alfa (s izuzetkom metotreksata, vidjeti dio 4.5.).
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON/BOTTLE PACK
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU VANJSKA KARTONSKA KUTIJA/BOČICA
English: In clinical trials no safety problems were observed when leflunomide and NSAIDs metabolised by CYP2C9 were co-administered.
Croatian: kliničkim ispitivanjima nisu zabilježeni problemi sa sigurnošću primjene kad se leflunomid davao istodobno s nesteroidnim protuupalnim lijekovima koji se metaboliziraju pomoću CYP2C9.
English: - Inflammation of the lung (interstitial lung disease), which may be fatal.
Croatian: intersticijska plućna bolest (uključujući intersticijski pneumonitis), koja može biti smrtonosna
English: White, round film-coated tablets, engraved with “10” on one side and “L” on the other.
Croatian: Bijele, okrugle, filmom obložene tablete, s oznakom „10“ utisnutom na jednoj strani i „L“ na drugoj.
English: A771726 plasma levels can be expected to be above 0.02 mg/l for a prolonged period.
Croatian: Očekuje se da će se koncentracija A771726 u plazmi, viša od 0,02 mg/l, zadržati duže vrijeme.
English: A more rapid elimination of A771726 was observed in haemodialysis subjects which was not due to extraction of drug in the dialysate.
Croatian: Znatno brža eliminacija A771726 zapažena je u hemodijaliziranih bolesnika, što nije bilo povezano s ekstrakcijom lijeka u
English: urticaria
Croatian: Cijepljenje
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER
Croatian: IME I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE GOTOVOG LIJEKA U PROMET
English: The PSUR cycle of Leflunomide Teva will correspond to the one attributed to the reference medicinal product, Arava, until otherwise specified.
Croatian: Plan predavanja PSUR-a za Leflunomid Teva trebao bi pratiti raspored prijave PSUR-a referentnog lijeka Arava, osim ako nije određeno drukčije.
English: - A decrease in the levels of phosphate in the blood.
Croatian: poremećaj koncentracije mokraćne kiseline u krvi;
English: Rheumatoid arthritis is a crippling form of arthritis.
Croatian: Reumatoidni artritis je oblik artritisa koji dovodi do invaliditeta.
English: What Leflunomide Teva looks like and contents of the pack Leflunomide Teva 10 mg film-coated tablets are white, round film-coated tablets, engraved with “10” on one side and “L” on the other.
Croatian: Kako Leflunomid Teva izgleda i sadržaj pakovanja Leflunomid Teva 10 mg filmom obložene tablete su bijele, okrugle, filmom obložene tablete, s utisnutom oznakom „10“ na jednoj strani i „L“ na drugoj.
English: - A cough or breathing problems as these may indicate inflammation of the lung (interstitial lung disease).
Croatian: - Kašlja ili problema s disanjem jer to može upućivati na upalu pluća (intersticijska plućna bolest)