FrancophonIA/ELRC3.0 huggingface dataset:
English: Evaluation of patients with heart failure should include periodic assessments of renal function, especially in elderly patients 75 years or older, and patients with impaired renal function.
Slovenian: Ocena bolnikov s srčnim popuščanjem mora vključevati redne kontrole delovanja ledvic, zlasti pri starejših bolnikih, starih 75 let ali več, in bolnikih z okvarjenim delovanjem ledvic.
English: Candesartan is mainly eliminated unchanged via urine and bile and only to a minor extent eliminated by hepatic metabolism (CYP2C9).
Slovenian: Kandesartan se v glavnem izloči nespremenjen v urinu in žolču in se le v majhni meri odstrani s presnovo v jetrih (CYP2C9).
English: Furthermore, candesartan induced hyperplasia/hypertrophy of the juxtaglomerular cells.
Slovenian: Poleg tega je kandesartan povzročil hiperplazijo/hipertrofijo jukstaglomerularnih celic.
English: Your doctor may increase this dose to 16 mg once a day and further up to 32 mg once a day depending on blood pressure response.
Slovenian: Zdravnik vam lahko ta odmerek poveča na 16 mg enkrat na dan in še dodatno do 32 mg enkrat na dan, odvisno od odziva krvnega tlaka.
English: LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE MEDICINAL PRODUCT, ROUTES OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
Slovenian: SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE, IMETNIKOV DOVOLJENJ ZA PROMET V DRŽAVAH ČLANICAH
English: There is no accumulation following multiple doses.
Slovenian: Po več odmerkih ne pride do kopičenja.
English: However, it should be taken into account that occasionally dizziness or weariness may occur during treatment with Atacand.
Slovenian: Vendar je treba upoštevati, da se med zdravljenjem z Atacandom občasno lahko pojavi omotica ali utrujenost.
English: • Changes in how your liver is working, including inflammation of the liver (hepatitis).
Slovenian: • Spremembe delovanja jeter, vključno z vnetjem jeter (hepatitisom).
English: Consequently, uptitration of Atacand and concomitant therapy may be more frequently needed for blood pressure control in black patients than in non-black patients (see section 5.1).
Slovenian: Zato utegne biti povečanje odmerka Atacanda in sočasno uporabljanih zdravil za obvladanje krvnega tlaka pogosteje potrebno pri bolnikih-črncih kot bolnikih-nečrncih (glejte poglavje 5.1).
English: For the purpose of harmonisation, the CHMP considered the national PI, answers provided by the marketing authorisation holder (MAH) and available scientific knowledge.
Slovenian: Za namen usklajevanja je CHMP upošteval nacionalno odobrene informacije o zdravilu, odgovore, ki jih je posredoval imetnik dovoljenja za promet z zdravilom, in razpoložljivi znanstveni podatki.
English: • Potassium supplements or salt substitutes containing potassium (medicines that increase the amount of potassium in your blood).
Slovenian: • dodatke kalija ali nadomestke soli, ki vsebujejo kalij (zdravila, ki povečujejo količino kalija v krvi).
English: The antihypertensive effect and tolerability of candesartan and losartan were compared in two randomised, double-blind studies in a total of 1,268 patients with mild to moderate hypertension.
Slovenian: Antihipertenzivni učinek in prenašanje kandesartana in losartana so primerjali v dveh randomiziranih, dvojno slepih študijah pri skupno 1268 bolnikih z blago do zmerno hipertenzijo.
English: However, the blood pressure response and the incidence of adverse events are similar after a given dose of Atacand in young and elderly patients (see section 4.2).
Slovenian: Toda odziv krvnega tlaka in incidenca neželenih učinkov sta po določenem odmerku Atacanda pri mladih in starejših bolnikih podobna (glejte poglavje 4.2).
English: In most of the MSs a dosage regimen up to a maximum of 32 mg dose was approved.
Slovenian: V večini držav članic je odobren režim odmerjanja do največjega odmerka 32 mg.
English: Total plasma clearance of candesartan is about 0.37 ml/min/kg, with a renal clearance of about 0.19 ml/min/kg.
Slovenian: Celotni plazemski očistek kandesartana je približno 0,37 ml/min/kg in njegov ledvični očistek je približno 0,19 ml/min/kg.
English: Candesartan cilexetil once daily provides effective and smooth blood pressure reduction over 24 hours, with little difference between maximum and trough effects during the dosing interval.
Slovenian: Cileksetilkandesartanat enkrat na dan zagotavlja učinkovito in enakomerno 24-urno znižanje krvnega tlaka z majhno razliko med največjim in najmanjšim učinkom med odmernim intervalom.
English: • Other medicines to help lower your blood pressure, including beta-blockers, diazoxide and ACE
Slovenian: • druga zdravila za zniževanje krvnega tlaka, vključno z zaviralci beta, diazoksidom in zaviralci
English: This is also confirmed in the recent meta-analysis by Law et al 2009, based on randomised trials.
Slovenian: To potrjuje tudi nedavno objavljena metaanaliza randomiziranih preskušanj, ki so jo izvedli Law et al 2009.
English: Section 4.7 Effects on Ability to Drive and Use Machines
Slovenian: Poglavje 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji
English: Denmark AstraZeneca A/S Roskildevej 22
Slovenian: AstraZeneca A/S Roskildevej 22
English: • Treatment of essential hypertension in adults.
Slovenian: • zdravljenje esencialne hipertenzije pri odraslih.
English: The table below presents adverse reactions from clinical trials and post-marketing experience.
Slovenian: Spodnja preglednica navaja neželene učinke iz kliničnih preskušanj in postmarketinškega obdobja.
English: The overall incidence of adverse events showed no association with dose or age.
Slovenian: Skupna incidenca neželenih učinkov ni bila povezana z odmerkom ali starostjo.
English: Atacand is contraindicated in patients with severe hepatic impairment and/or cholestasis (see sections 4.3 and 5.2).
Slovenian: Atacand je kontraindiciran pri bolnikih s hudo okvaro jeter in/ali holestazo (glejte poglavji 4.3 in 5.2).
English: After administration of a single dose of candesartan cilexetil, onset of antihypertensive effect generally occurs within 2 hours.
Slovenian: Po uporabi enkratnega odmerka cileksetilkandesartanata se antihipertenzivni učinek po navadi pojavi v 2 urah.
English: Do not take Atacand
Slovenian: Ne jemljite zdravila Atacand
English: In individual case reports of overdose (of up to 672 mg candesartan cilexetil) patient recovery was uneventful.
Slovenian: Opisani so posamezni primeri prevelikega odmerjanja (do 672 mg cileksetilkandesartanata); okrevanje bolnikov je v teh primerih potekalo brez zapletov.
English: Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Slovenian: Kandesartan se ne veže oz. ne zavira drugih hormonskih receptorjev ali ionskih kanalčkov, pomembnih za kardiovaskularno regulacijo.
English: Candesartan increases renal blood flow and either has no effect on or increases glomerular filtration rate while renal vascular resistance and filtration fraction are reduced.
Slovenian: Kandesartan poveča pretok krvi skozi ledvice in bodisi ne vpliva na hitrost glomerularne filtracije ali pa jo poveča, medtem ko sta ledvični žilni upor in filtracijska frakcija zmanjšana.
English: This belongs to a group of medicines called angiotensin II receptor antagonists.
Slovenian: Ta učinkovina spada v skupino zdravil, ki jih imenujemo antagonisti receptorjev angiotenzina II.
English: Results from two clinical studies investigating the pharmacokinetic (PK) profile of candesartan in patients with impaired hepatic function and the publication by Hoogkamer et al 1998, where a starting dose of 12 mg was used, indicate that mild to moderate hepatic impairment has no relevant effect on candesartan PK, and thus no dose adjustment is required.
Slovenian: Rezultati dveh kliničnih študij, v katerih so preučevali farmakokinetični profil kandesartana pri bolnikih z okvaro jeter, in objava študije Hoogkamer et al 1998, v kateri so uporabili začetni odmerek 12 mg, kažejo, da blaga do zmerna okvara jeter nima pomembnega vpliva na farmakokinetiko kandesartana, zato prilagajanje odmerka ni potrebno.
English: Angiotensin II is the primary vasoactive hormone of the renin-angiotensin-aldosterone system and plays a role in the pathophysiology of hypertension, heart failure and other cardiovascular disorders.
Slovenian: Angiotenzin II je primarni vazoaktivni hormon sistema renin-angiotenzin-aldosteron in ima vlogo v patofiziologiji hipertenzije, srčnega popuščanja in drugih kardiovaskularnih bolezni.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze, ne smejo jemati tega zdravila.
English: Very rare Leukopenia, neutropenia and agranulocytosis
Slovenian: Zelo redki levkopenija, nevtropenija in agranulocitoza
English: SCIENTIFIC CONCLUSIONS AND GROUNDS FOR AMENDMENT OF THE SUMMARY OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET PRESENTED BY THE EUROPEAN MEDICINE AGENCY
Slovenian: ZNANSTVENI ZAKLJUČKI IN PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJA IN NAVODILA ZA UPORABO, KI JIH JE PREDSTAVILA EVROPSKA AGENCIJA ZA ZDRAVILA
English: Caution should be observed when initiating therapy and correction of hypovolemia should be attempted.
Slovenian: Pri uvedbi zdravljenja je potrebna previdnost in hipovolemijo je treba poskusiti korigirati.
English: If this is not sufficient, plasma volume should be increased by infusion of, for example, isotonic saline solution.
Slovenian: Če to ne zadošča, je treba povečati volumen plazme z infuzijo, npr. z infuzijo fiziološke raztopine.
English: C-labelled candesartan cilexetil, approximately 26% of the dose is excreted in the urine as candesartan and 7% as an inactive metabolite while approximately 56% of the dose is recovered in the faeces as candesartan and 10% as the inactive metabolite.
Slovenian: 26 % odmerka izloči v urinu kot kandesartan in 7 % kot neaktivni presnovek, približno 56 % odmerka pa se pojavi v blatu kot kandesartan in 10 % kot neaktivni presnovek.
English: Atacand may also be administered with other antihypertensive agents.
Slovenian: Atacand se lahko uporablja tudi z drugimi antihipertenzivi.
English: Germany Takeda Pharma GmbH Viktoriaallee 3-5
Slovenian: Takeda Pharma GmbH Viktoriaallee 3-5
English: The CHMP noted that there is plausible effect based on the pharmacologic action of the drug to affect the ability to drive thus this section was harmonised to reflect that ‘dizziness' and ‘weariness' can occur.
Slovenian: CHMP je ugotovil, da je zaradi farmakološkega delovanja zdravila možen učinek na sposobnost vožnje, zato je bilo to poglavje usklajeno tako, da odraža možnost pojava „omotice“ in „utrujenosti.“
English: Periodic monitoring of serum creatinine and potassium is recommended (see section 4.4).
Slovenian: Priporočljive so redne kontrole kreatinina in kalija v serumu (glejte poglavje 4.4).
English: The use of AIIRAs in the second and third trimester is contraindicated.
Slovenian: Uporaba antagonistov AIIRA v drugem in tretjem trimesečju nosečnosti je kontraindicirana.
English: Very rare Increased liver enzymes, abnormal hepatic function or hepatitis
Slovenian: Zelo redki zvišanje jetrnih encimov, nenormalno delovanje jeter ali hepatitis
English: There is no experience in patients with severe hepatic impairment.
Slovenian: Izkušenj pri bolnikih s hudo okvaro jeter ni.
English: Germany AstraZeneca GmbH 22876 Wedel, Germany
Slovenian: AstraZeneca GmbH 22876 Wedel Germany
English: The adverse experience profile of Atacand in heart failure patients was consistent with the pharmacology of the drug and the health status of the patients.
Slovenian: Značilnosti neželenih učinkov Atacanda pri bolnikih s srčnim popuščanjem so se skladali s farmakologijo zdravila in zdravstvenim stanjem bolnikov.
English: - An increased amount of potassium in your blood, especially if you already have kidney problems or heart failure.
Slovenian: - Več kalija v krvi, zlasti če že imate težave z ledvicami ali srčno popuščanje.
English: Use of candesartan with lithium is not recommended.
Slovenian: Sočasna uporaba kandesartana in litija ni priporočljiva.
English: Based on pharmacological considerations, the main manifestation of an overdose is likely to be symptomatic hypotension and dizziness.
Slovenian: Na podlagi farmakologije sta najverjetnejša glavna znaka prevelikega odmerjanja simptomatska hipotenzija in omotica.
English: There is no experience with the use of Atacand in children (below the age of 18 years).
Slovenian: Pri otrocih (mlajših od 18 let) ni izkušenj z uporabo zdravila Atacand.
English: • When you are prescribed Atacand, discuss with your doctor before drinking alcohol.
Slovenian: • Ko vam predpišejo zdravilo Atacand se morate glede pitja alkoholnih pijač posvetovati z zdravnikom.
English: In two studies, both including patients with mild to moderate hepatic impairment, there was an increase in the mean AUC of candesartan of approximately 20% in one study and 80% in the other study (see section 4.2).
Slovenian: V dveh študijah, ki sta vključevali bolnike z blago do zmerno okvaro jeter so ugotovili povečanje povprečne AUC kandesartana za približno 20 % v eni in 80 % v drugi študiji (glejte poglavje 4.2).
English: Data from in vitro and in vivo mutagenicity testing indicates that candesartan will not exert mutagenic or clastogenic activities under conditions of clinical use.
Slovenian: Podatki testiranja mutagenosti in vitro in in vivo kažejo, da kandesartan v pogojih klinične uporabe ne deluje mutageno ali klastogeno.
English: Atacand contains lactose.
Slovenian: Atacand vsebuje laktozo.
English: In hypertension, candesartan causes a dose-dependent, long-lasting reduction in arterial blood pressure.
Slovenian: Pri hipertenziji kandesartan povzroči od odmerka odvisno, dolgotrajno znižanje arterijskega krvnega tlaka.
English: Atacand is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Slovenian: Zdravila Atacand ne priporočamo v zgodnji nosečnosti in ga ne smete jemati, če ste noseči več kot 3 mesece, saj lahko resno poškoduje vašega otroka, če ga uporabljamo v tem obdobju (glejte poglavje o nosečnosti).
English: Very rarely, hypotension may be severe such that it may warrant the use of intravenous fluids and/or vasopressors.
Slovenian: Zelo redko je lahko hipotenzija tako huda, da mora bolnik dobiti intravensko tekočino in/ali vazokonstriktorje.
English: Based on the above the CHMP considers the benefit/risk ratio of Atacand to be favourable and the harmonised PI to be approvable.
Slovenian: Na osnovi navedenega je CHMP menil, da je razmerje med koristmi in tveganji za zdravilo Atacand ugodno in da je usklajeno navodilo za uporabo mogoče odobriti.
English: When AIIRAs are administered simultaneously with non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Slovenian: Če so AIIRA uporabljeni sočasno z nesteroidnimi protivnetnimi zdravili (NSAID) (tj. selektivnimi zaviralci COX-2, acetilsalicilno kislino (> 3 g/dan) ali neselektivnimi nesteroidnimi protivnetnimi zdravili), se lahko antihipertenzivni učinek zmanjša.
English: Section 4.6 Pregnancy and Lactation
Slovenian: Poglavje 4.6 Nosečnost in dojenje
English: Patients who respond with some reduction in blood pressure to candesartan monotherapy at lower doses may have further advantage of the full 32 mg dose.
Slovenian: Bolniki, ki se na monoterapijo z manjšimi odmerki kandesartana odzovejo z določenim znižanjem krvnega tlaka, lahko dodatno izkoristijo celoten odmerek 32 mg.
English: Withdrawals from treatment due to adverse events were similar with candesartan cilexetil (3.1%) and placebo (3.2%).
Slovenian: Delež prekinitev zdravljenja zaradi neželenih učinkov je bil s cileksetilkandesartanatom (3,1 %) podoben kot s placebom (3,2 %).
English: A reduced amount of sodium in your blood.
Slovenian: Manj natrija v krvi.
English: Monitoring of potassium should be undertaken as appropriate.
Slovenian: Koncentracijo kalija je treba kontrolirati, kot je primerno.
English: If this is severe then you may notice weakness, lack of energy, or muscle cramps.
Slovenian: Če je to zmanjšanje hudo, lahko občutite šibkost, pomanjkanje energije ali mišične krče.
English: By this definition, the most commonly reported adverse reactions were dizziness/vertigo, headache and respiratory infection.
Slovenian: Po tej opredelitvi so bili najpogostejši neželeni učinki omotica/vrtoglavica, glavobol in okužba dihal.
English: As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic cardiopathy or ischaemic cerebrovascular disease could result in a myocardial infarction or stroke.
Slovenian: Kot velja za vsa antihipertenzivna zdravila, lahko čezmerno znižanje krvnega tlaka pri bolnikih z ishemično kardiopatijo ali ishemično cerebrovaskularno boleznijo izzove miokardni infarkt ali možgansko kap.
English: However, reference to an increased antihypertensive effect when candesartan cilexetil is combined with a CCB amlodipine or felodipine was not included in section 4.2 but rather in 5.1.
Slovenian: Vendar je bil sklic na povečanje antihipertenzivnega učinka kombiniranja kandesartan cileksetila z zaviralcem kalcijevih kanalčkov amlodipinom ali felodipinom vključen v poglavje 5.1 in ne v poglavje 4.2.
English: The terminal t½ of candesartan was approximately doubled in patients with severe renal impairment.
Slovenian: Terminalni t1/2 kandesartana se je pri bolnikih s hudo okvaro ledvic približno podvojil.
English: The recommended starting dose and usual maintenance dose of candesartan is 8 mg.
Slovenian: Priporočljiv začetni odmerek in običajni vzdrževalni odmerek kandesartana sta 8 mg.
English: The use of AIIRAs is not recommended during the first trimester of pregnancy (see section 4.4).
Slovenian: Uporaba AIIRA ni priporočljiva v prvem trimesečju nosečnosti (glejte poglavje 4.4).
English: There is no effect on ACE and no potentiation of bradykinin or substance P. In controlled clinical trials comparing candesartan with ACE inhibitors, the incidence of cough was lower in patients receiving candesartan cilexetil.
Slovenian: Ne vpliva na ACE in ne stopnjuje delovanja bradikinina ali snovi P. V kontroliranih kliničnih preskušanjih, ki so primerjala kandesartan z zaviralci ACE, je bila incidenca kašlja manjša pri bolnikih, ki so prejemali cileksetilkandesartanat.
English: If you forget to take Atacand Do not take a double dose to make up for a forgotten tablet.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnjo tableto.
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately and, if appropriate, alternative therapy should be started.
Slovenian: Ko je nosečnost potrjena, moramo zdravljenje z AIIRA takoj prekiniti in če je primerno začeti z nadomestnim zdravljenjem.
English: Alcohol may make you feel faint or dizzy.
Slovenian: Alkohol vam lahko povzroči omotico ali omedlevico.
English: An initial dose of 4 mg may be considered in patients at risk for hypotension, such as patients with possible volume depletion (see section 4.4).
Slovenian: Začetni odmerek 4 mg pride v poštev pri bolnikih s tveganjem za hipotenzijo, npr. pri bolnikih z možno hipovolemijo (glejte poglavje 4.4).
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Slovenian: Dojenčke, katerih matere so bile izpostavljene AIIRA moramo opazovati zaradi hipotenzije (glejte poglavji 4.3 in 4.4).
English: Compounds which have been investigated in clinical pharmacokinetic studies include hydrochlorothiazide, warfarin, digoxin, oral contraceptives (i.e. ethinylestradiol/levonorgestrel), glibenclamide, nifedipine and enalapril.
Slovenian: Med učinkovinami, ki so jih raziskali v kliničnih farmakokinetičnih študijah, so hidroklorotiazid, varfarin, digoksin, peroralni kontraceptivi (tj. etinilestradiol/levonorgestrel), glibenklamid, nifedipin in enalapril.
English: • Effects on how your kidneys work, especially if you already have kidney problems or heart failure.
Slovenian: • Vpliv na delovanje ledvic, zlasti če že imate težave z ledvicami ali srčno popuščanje.
English: Your resistance to infection may be decreased and you may notice tiredness, an infection or a fever.
Slovenian: Odpornost proti okužbam se zato lahko zmanjša in opazite lahko utrujenost, okužbo ali zvišano telesno temperaturo.
English: Patients with primary hyperaldosteronism will not generally respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin-aldosterone system.
Slovenian: Bolniki s primarnim aldosteronizmom se praviloma ne odzovejo na antihipertenzivna zdravila, ki delujejo z zavrtjem sistema renin-angiotenzin-aldosteron.
English: During dialysis the blood pressure may be particularly sensitive to AT1-receptor blockade as a result of reduced plasma volume and activation of the renin-angiotensin-aldosterone system.
Slovenian: Med dializo je lahko krvni tlak še posebej občutljiv za blokado receptorjev AT1, in sicer zaradi zmanjšanega volumna plazme in aktiviranja sistema renin-angiotenzin-aldosteron.
English: The name of your medicine is Atacand.
Slovenian: Vaše zdravilo se imenuje Atacand.
English: Based on the information provided, the CHMP endorsed the harmonised text for Angiotensin II receptor antagonists as the standard warning elaborated by the CHMP's Pharmacovigilance Working Party for all Angiotensin II receptor antagonists (AIIRAs): the use of AIIRAs in the first trimester of pregnancy is not recommended; the use of AIIRAs in the second and third trimester is contraindicated.
Slovenian: CHMP je na osnovi predloženih podatkov kot usklajeno besedilo za antagoniste receptorjev angiotenzina II potrdil standardno opozorilo, ki ga je za antagoniste receptorjev za angiotenzin II (AIIRA) pripravila delovna skupina CHMP za farmakovigilanco: uporaba antagonistov AIIRA v prvem trimesečju nosečnosti ni priporočljiva, uporaba v drugem in tretjem trimesečju je kontraindicirana.
English: When candesartan cilexetil is used together with hydrochlorothiazide, the reduction in blood pressure is additive.
Slovenian: Če je cileksetilkandesartanat uporabljen skupaj s hidroklorotiazidom, je znižanje krvnega tlaka aditivno.
English: It may also occur in hypertensive patients with intravascular volume depletion such as those receiving high dose diuretics.
Slovenian: Pojavi se lahko tudi pri hipertenzivnih bolnikih s hipovolemijo, npr. bolnikih, ki dobivajo velike odmerke diuretikov.
English: Therefore Atacand should not be given to children.
Slovenian: Zato otroci ne smejo dobivati zdravila Atacand.
English: What Atacand is and what it is used for Before you take Atacand How to take Atacand Possible side effects How to store Atacand Further information
Slovenian: Kaj je zdravilo Atacand in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Atacand Kako jemati zdravilo Atacand Možni neželeni učinki
English: This medicinal product was considered for SPC harmonisation and a referral was triggered in order to resolve divergences and harmonise the nationally authorised product information (PI) across Europe.
Slovenian: Za zdravilo je bilo načrtovano usklajevanje povzetkov glavnih značilnosti zdravila, zato je bil uveden napotitveni postopek, da bi se razrešile razlike in uskladile nacionalno odobrene informacije o zdravilu v Evropi.
English: However, patients treated with candesartan, an ACE inhibitor and a potassium sparing diuretic experienced increased risk of hyperkalaemia.
Slovenian: Vendar se je pri bolnikih, ki so bili zdravljeni s kandesartanom, zaviralcem ACE in diuretikom, ki varčuje s kalijem, povečalo tveganje hiperkaliemije.