FrancophonIA/ELRC3.0 huggingface dataset:
English: Lipid-modifying agents Lomitapide
Maltese: Aġenti li jimmodifikaw il-lipidi
English: 100, single dose 500q12h ↑ 11-fold ↑ 4-fold Concomitant use of sildenafil for the treatment of erectile dysfunction with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer should be with caution and in no instance should sildenafil doses exceed 25 mg in 48 hours (see also section 4.4).
Maltese: L-użu ta' sildenafil għall-kura tad-disfunzjoni erettili flimkien ma' ritonavir dożat bħala aġent antiretrovirali jew biex iżid l-effett farmakokinetiku għandu jsir b'attenzjoni, u fl-ebda każ m'għandhom id-dożi ta' sildenafil jeċċedu 25 mg fi 48 siegħa (ara ukoll sezzjoni 4.4).
English: • seizures (fits)
Maltese: • għatx (deidratazzjoni)
English: Bosentan, riociguat (used for pulmonary arterial hypertension) as ritonavir may increase the blood levels of this medicine.
Maltese: - Bosentan, riociguat (użat għal-pressjoni għolja fl-arterji pulmonari) għax ritonavir jista' jżid illivelli ta' din il-mediċina fid-demm.
English: The co-administration of riociguat with ritonavir is not recommended (see section 4.4 and refer to riociguat SmPC).
Maltese: Il-frekwenza ta' dan mhux magħrufa (ara sezzjoni 4.4).
English: After multiple dosing of ritonavir to healthy volunteers (500 mg twice daily) and subjects with mild to moderate hepatic impairment (Child Pugh Class A and B, 400 mg twice daily) exposure to ritonavir after dose normalisation was not significantly different between the two groups.
Maltese: Wara l-għoti ta' aktar minn doża waħda ta' ritonavir lil voluntiera b'saħħithom (500 mg darbtejn kuljum) u lil soġġetti b'indeboliment tal-fwied li jvarja minn ħafif għal moderat (Child Pugh Klassi A u B, 400 mg darbtejn kuljum), l-esponiment għal ritonavir wara li d-dożaġġ reġa' beda jingħata b'mod normali ma kienx differenti b'mod sinifikanti bejn iż-żewġ gruppi.
English: Strong CYP3A4 inhibitors such as protease inhibitors may increase bedaquiline exposure which could potentially increase the risk of bedaquiline-related adverse reactions.
Maltese: Inibituri qawwija ta' CYP3A4 bħal inibituri tal-protease jistgħu jżidu l-espożizzjoni ta' bedaquiline li potenzjalment tista' żżid r-riskju ta' reazzjonijiet avversi relatati ma' bedaquiline.
English: Clinical trials confirmed the safety and efficacy of 600 mg amprenavir twice daily with ritonavir 100 mg twice daily.
Maltese: Provi kliniċi kkonfermaw is-sigurtà u l-effikaċja ta' 600 mg amprenavir darbtejn kuljum flimkien ma' 100 mg ritonavir darbtejn kuljum.
English: ↑ 29 fold ND
Maltese: ↑ bi 11-il darba ↑ b'29 darba
English: Lopinavir co-formulated with ritonavir (lopinavir/ritonavir) 400 mg/100 mg or 800 mg/200 mg. Saquinavir 1,000 mg twice daily with ritonavir 100 mg twice daily in ART experienced patients.
Maltese: Meta ritonavir jintuża biex iżid l-effett farmakokinetiku fil-livell ta' 100 mg u 200 mg, wieħed ma jistax jassumi li t-twissijiet u l-prekawzjonijiet segwenti se japplikaw ukoll.
English: 200 q12 h, 2 days
Maltese: 200 q12 h, 13
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymtomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Maltese: F'pazjenti infettati bl-HIV li, meta tinbeda t-terapija antiretrovirali kombinata (CART), ikollhom defiċjenza immunitarja severa, tista' tirriżulta reazzjoni infjammatorja għall-patoġeni li ma jikkaġunawx sintomi jew li huma opportunisti residwali.
English: Dose of
Maltese: U KWANTITATTIVA
English: Decreased white blood cells, decreased haemoglobin, decreased neutrophils, increased eosinophils, thrombocytopenia
Maltese: Tnaqqis fiċ-ċelluli bojod tad-demmf, tnaqqis flemoglobina, tnaqqis fin-neutrophils, żieda fl-eosinophils, tromboċitopenja
English: In cases of co-administration of ritonavir (100 mg twice daily) and indinavir (800 mg twice daily) caution is warranted as the risk of nephrolithiasis may be increased.
Maltese: F'każi tatteħid flimkien ta' ritonavir (100 mg darbtejn kuljum) u indinavir (800 mg darbtejn kuljum) għandha tiġi eżerċitata attenzjoni minħabba li r-riskju ta' ġebla fil-kliewi jista' jiżdied.
English: Four ritonavir metabolites have been identified in man.
Maltese: Fil-bniedem ġew identifikati erba' metaboliti ta' ritonavir.
English: Co-administration of bosentan and ritonavir may increase steady state bosentan maximum concentrations (Cmax) and area under the curve (AUC).
Maltese: Amministrazzjoni ta' bosentan flimkien ma' ritonavir jista' jżid ilkonċentrazzjonijiet massimi (Cmax)ta' bosentan fl-istat fiss u l-erja ta' taħt ilkurva (AUC).
English: What Ritonavir Mylan looks like and contents of the pack Ritonavir Mylan film-coated tablets are yellow, capsule shaped and marked with ‘M163' on one side and plain on the other.
Maltese: Il-pilloli miksija b'rita Ritonavir Mylan huma sofor, b'forma ta' kapsula u mmarkati b'‘M163' fuq naħa waħda u xejn fuq in-naħa l-oħra.
English: Adult Use
Maltese: Użu mill-Adulti
English: Animal data have shown reproductive toxicity (see section 5.3).
Maltese: Informazzjoni fuq l-annimali uriet tossiċità riproduttiva (ara 5.3). Ritonavir jista' jintuża waqt it-tqala jekk ikun meħtieġ klinikament.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 100 mg of ritonavir.
Maltese: DIKJARAZZJONI TAS-SUSTANZA(I) ATTIVA Kull pillola miksija b'rita fiha 100 mg ta' ritonavir.
English: The concomitant administration with quetiapine is contraindicated (see section
Maltese: L-amministrazzjoni flimkien ma' quetiapine huwa kontraindikat (ara sezzjoni 4.5).
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Maltese: Pazjenti li jbatu minn epatite B jew C u li jkunu qeghdin jieħdu terapija antiretrovirali kombinata għandhom riskju akbar ta' reazzjonijiet epatiċi avversi li huma severi u potenzjalment fatali.
English: Although rifampicin may induce metabolism of ritonavir, limited data indicate that when high doses of ritonavir (600 mg twice daily) is co-administered with rifampicin, the additional inducing effect of rifampicin (next to that of ritonavir itself) is small and may have no clinical relevant effect on ritonavir levels in high-dose ritonavir therapy.
Maltese: Għalkemm rifampicin jista' jġiegħel il-metaboliżmu ta' ritonavir, informazzjoni limitata tindika, li meta dożi għolja ta' ritonavir (600 mg darbtejn kuljum) jingħataw flimkien ma' rifampicin, l-effett addizzjonali li jġiegħel rifampicin (meta mqabbel ma' dak ta' ritonavir innifsu) huwa żgħir u jista' jkun li ma jħallix effett li huwa klinikament sinifikanti fuq il-livelli ta' ritonavir f'każ ta' terapija fejn jingħataw dożi għoljin ta' ritonavir.
English: The extent of increase in AUC and Cmax depends on the timing of ritonavir administration.
Maltese: L-estent ta' żieda fl-AUC u Cmax jiddependi millħin ta' amministrazzjoni ta' ritonavir.
English: Induction of CYP1A2 and CYP2C9 lead to decreased levels of R-warfarin while little pharmacokinetic effect is noted on S-warfarin when co-administered with ritonavir.
Maltese: Fil-waqt li l-effett farmakokinetiku innotat fuq S-warfarin meta dan ittieħed ma' ritonavir huwa żgħir, l-induzzjoni ta' CYP1A2 u CYP2C9 wassal għal tnaqqis fil-livelli ta' R-warfarin.
English: 200 q12 h/coadministered
Maltese: 40 mg, doża waħda 200 q12 h/ co amministrat
English: ↑ 2.4fold ↑ 11 fold
Maltese: ↑ bi 11-il darba ↑ b'4 darbiet
English: • increase in urination
Maltese: • menstrwazzjoni esaġerata
English: Animal studies as well as in vitro experiments with human hepatic microsomes indicated that ritonavir primarily underwent oxidative metabolism.
Maltese: Studji fuq l-annimali, kif ukoll esperimenti in vitro b'mikrosomi epatiċi tal-bniedem urew li primarjament ritonavir għadda minn metaboliżmu ossidattiv.
English: Hypersensitivity including urticaria, and face oedema
Maltese: Sensittività eċċessiva, li tinkludi urtikarja u edima fil-wiċċ
English: Pethidine, piroxicam, propoxyphene Ritonavir co-administration is likely to result in increased plasma concentrations of pethidine, piroxicam, and propoxyphene and is therefore contraindicated (see section 4.3).
Maltese: It-teħid ta' ritonavir flimkien ma' pethidine, piroxicam, propoxyphene x'aktarx li jwassal għal żieda fil-konċentrazzjoni fil-plażma ta' meperidine, piroxicam, u propoxyphene, u għalhekk huwa kontro-indikat (ara sezzjoni 4.3).
English: • muscle aches (pain), tenderness or weakness
Maltese: • attakk tal-epilessija (aċċessjonijiet)
English: 100 q12 h 500 q12 h
Maltese: 100,doża waħda 500 q12 h
English: Amlodipine, diltiazem, nifedipine Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of calcium channel antagonists.
Maltese: Ritonavir dożat biex iżid l-effett farmakokinetiku jew bħala aġent antiretrovirali jimpedixxi s- CYP3A4, u għalhekk huwa mistenni li jżid ilkonċentrazzjoni fil-plażma tal-mediċini li jimblukkaw ir-riċetturi tal-kanali tal-kalċju.
English: 600 mg twice daily
Maltese: 600 mg darbtejn kuljum
English: • reduced kidney function
Maltese: • tnaqqis fil-funzjoni tal-kliewi
English: Trazodone is a CYP3A4 substrate and co-administration of ritonavir is expected to increase trazodone levels.
Maltese: Bħala riżultat ta' impediment minn CYP3A4, ritonavir iżid il-livelli tas-serum ta' saquinavir.
English: Across dose groups, ritonavir oral clearance (CL/F/m2) was approximately 1.5 to 1.7 times faster in paediatric patients above 2 years of age than in adult subjects.
Maltese: Bejn il-gruppi ta'doża differenti ittneħħija ta' ritonavir mill-ħalq (CL/F/m²) kienet ta' bejn wieħed u ieħor minn 1.5 sa 1.7 drabi aktar mgħaġġla f'pazjenti pedjatriċi li kellhom iżjed minn sentejn, milli minn suġġetti adulti.
English: The concomitant use of ritonavir is not recommended due to potential increase in vorapaxar exposure (see section 4.5).
Maltese: L-użu konkomitanti ta' ritonavir mhuwiex rakkomandat minħabba ż-żieda potenzjali fl-espożizzjoni ta' vorapaxar (ara sezzjoni 4.5).
English: 100, single oral dose
Maltese: 100 doża waħda orali
English: If ritonavir is co-administered with parenteral midazolam, it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Maltese: Jekk ritonavir jingħata flimkien ma' midazolam parenterali, dan għandu jseħħ f'post għal kura intensiva (ICU) jew post simili fejn ikunu jsiru osservazzjoni klinikali mill-qrib u treġija medika adegwata f'każ li jkun hemm deppressjoni respiratorja u/jew sedazzjoni twila aktar milli sippost.
English: Maximal inhibition of metabolism of the co-administered protease inhibitor is generally achieved with ritonavir doses of 100 mg daily to 200 mg twice daily, and is dependent on the co-administered protease inhibitor.
Maltese: L-impediment massimali tal-metaboliżmu ta'l-impeditur protejaż li jingħata ma' ritonavir ġeneralment jintlaħaq b'dożi ta' ritonavir ta' minn 100 mg kuljum sa 200 mg darbtejn kuljum, u dan jiddependi fuq l-impeditur protejaż li jingħata ma' ritonavir.
English: Initiate treatment with saquinavir 500 mg twice daily with ritonavir 100 mg twice daily for the first 7 days, then saquinavir 1,000 mg twice daily with ritonavir 100 mg twice daily in ART-naïve patients.
Maltese: 1000 mg saquinavir darbtejn kuljum ma' 100 mg ritonavir darbtejn kuljum f'pazjenti li diġa ħadu ART. Ibda il-kura b'500 mg saquinavir darbtejn kuljum flimkien ma' 100mg ritonavir darbtejn kuljum flewwel sebat ijiem, imbagħad 1000 mg saquinavir darbtejn kuljum flimkien ma' 100 mg ritonavir darbtejn kuljum f'pazjenti li ma ħadux kura bl-ART qabel.
English: • increase in cholesterol
Maltese: • żieda fil-livelli tal-kolesterol
English: Treatment should be initiated at 300 mg (3 tablets) twice daily for a period of three days and increased by 100 mg (1 tablet) twice daily increments up to 600 mg twice daily over a period of no longer than 14 days.
Maltese: Il-kura għandha tinbeda bi 300 mg (3 pilloli) darbtejn kuljum għal perijodu ta' tlett ijiem, u tiżdied b'100 mg (pillola waħda) darbtejn kuljum sakemm wieħed jasal sa 600 mg darbtejn kuljum, u dana fuq perijodu ta' mhux akatr minn 14 il-ġurnata.
English: 500q12h,↓ 36% ↓ 38% Increased methadone dose may be necessary when concomitantly administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer due to induction of glucuronidation.
Maltese: 300 q6h Zidovudine↓25% MD Ritonavir jista' jikkaġuna l-glukuronidazzjoni ta' zidovudine, li jirriżulta f'livelli ta' zidovudine li jkunu ftit aktar baxxi.
English: • blurred vision
Maltese: • visjoni mċajpra
English: NAME OF THE MEDICINAL PRODUCT Ritonavir Mylan 100 mg film-coated tablets
Maltese: Ritonavir Mylan 100 mg pilloli miksija b'rita
English: 100q12h ↑ 7.2-fold ↑ 4.7-fold Ritonavir increases plasma concentrations of simeprevir as a result of CYP3A4 inhibition.
Maltese: 100 q12h Amprenavir ↑ bi 2.4 drabi ↑ bi 11-il darba Bħala riżultat ta' impediment minn CYP3A4, ritonavir iżid il-livelli tas-serum ta' amprenavir (minn fosamprenavir).
English: Increased plasma concentrations of ergot derivatives leading to acute ergot toxicity, including vasospasm and ischaemia.
Maltese: Żieda fil-konċentrazzjoni fil-plażma ta' derivattivi tal-ergotina li twassal għal tossiċità akuta tal-ergotina, li tinkludi għeluq tal-vini u iskemija.
English: There are some medicines you cannot take at all with ritonavir.
Maltese: Hemm ċerti mediċini li inti assolutament ma tistax tieħu ma' ritonavir.
English: Ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer
Maltese: Ritonavir dożat bħala aġent antiretrovirali jew biex iżid l-effett farmakokinetiku
English: Pharmacokinetic enhancement by ritonavir is based on ritonavir's activity as a potent inhibitor of CYP3A- mediated metabolism.
Maltese: Iż-żieda fl-effett farmakokinetiku permezz ta' ritonavir huwa bbażat fuq l-attivita` tiegħu bħala impeditur potenti tal-metaboliżmu medjat b'CYP3A.
English: The HMG-CoA reductase inhibitors simvastatin and lovastatin are highly dependent on CYP3A for metabolism, thus concomitant use of ritonavir with simvastatin or lovastatin is not recommended due to an increased risk of myopathy including rhabdomyolysis.
Maltese: Il-metaboliżmu ta' pravastatin u fluvastatin ma jiddependix minn CYP3A, u interazzjonijiet ma' ritonavir m'humiex mistennija.
English: Increased plasma concentrations of clozapine and pimozide.
Maltese: Clozapine, pimozide Żieda fil-konċentrazzjoni fil-plażma ta' clozapine u pimozide.
English: Animal studies do not indicate harmful effects of ritonavir on fertility (see section 5.3).
Maltese: Studji flannimali ma jindikawx effetti ta' ħsara ta' ritonavir fuq il-fertilità (ara sezzjoni 5.3).
English: Plasma concentrations of ritonavir after administration of a single 100 mg dose tablet are similar to the 100 mg soft gelatin capsule under fed conditions.
Maltese: Il-konċentrazzjoni fil-plażma ta' ritonavir wara l-għoti ta' pillola waħda ta' doża ta' 100 mg, hija simili għal dik tal-kapsula ratba tal-ġelatina ta' 100 mg f'kondizzjoni fejn ilpazjent ikun kiel.
English: Ritonavir is likely to change the uterine bleeding profile and reduce the effectiveness of estradiol-containing contraceptives (see section 4.4).
Maltese: X'aktarx li ritonavir ibiddel il-profil ta' telf ta' demm mill-ġuf u jnaqqas l-effettività ta' kontraċettivi li jkun fihom estradiol (ara sezzjoni 4.4).
English: Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infected patients (adults and children of 2 years of age and older).
Maltese: Ritonavir huwa indikat li jittieħed flimkien ma' aġenti oħra antiretrovirali għall-kura ta' pazjenti infettati bl-HIV-1 (adulti u tfal ta' sentejn jew aktar fl-eta`).
English: Patients without this disease may use sildenafil for impotence (erectile dysfunction) under their doctor's supervision (see the section on Other medicines and Ritonavir Mylan); avanafil or vardenafil (used to treat erectile dysfunction); colchicine (used to treat gout) if you have kidney and/or liver problems (see the section on Other medicines and Ritonavir Mylan); products containing St John's wort (Hypericum perforatum) as this may stop ritonavir from working properly.
Maltese: (ara s-sezzjoni dwar Mediċini oħra u Ritonavir Mylan); - avanafil jew vardenafil (użati biex jikkuraw disfunzjoni erettili); - colchicine (użat biex jikkura l-gotta) jekk għandek problemi fil-kliewi u/jew fil-fwied (ara s-sezzjoni dwar Mediċini oħra u Ritonavir Mylan); - prodotti li fihom l-fexfiex tar-raba' (Hypericum perforatum) peress li din tista' twaqqaf lil ritonavir milli jaħdem kif sippost.
English: 100q12h ↓ 39% ↓ 24% Concomitant use of ritonavir dosed as an antiretroviral agent and voriconazole is contraindicated due to reduction in voriconazole concentrations (see section 4.3).
Maltese: L-użu ta' ritonavir dożat bħala aġent antiretrovirali flimkien ma' voriconazole huwa kontro-indikat minħabba tnaqqis fil-konċentrazzjoni ta' voriconazole (ara sezzjoni 4.3).
English: Caution should be exercised in administering afatinib with ritonavir (refer to the afatinib SmPC).
Maltese: Kawtela għandha tiġi eżerċitata flamministrazzjoni ta' afatinib ma' ritonavir (irreferi għall-SmPC ta' afatinib).
English: There have been reports of muscle pain, tenderness or weakness, particularly when taking medicines to lower cholesterol in combination with antiretroviral therapy, including protease inhibitors and nucleoside analogues.
Maltese: Kien hemm rapporti ta' uġigħ fil-muskoli, sensittività jew dgħjufija, partikolarment meta jkunu qegħdin jittieħdu prodotti mediċinali biex jitbaxxa l-livell tal-kolosterol, flimkien ma' terapija antiretrovirali, inklużi impedituri protejaż u analogi nuklèoside.
English: For some products, contraindications may be more relevant when ritonavir is used as an antiretroviral agent than when ritonavir is used as a pharmacokinetic enhancer (e.g. rifabutin and voriconazole):
Maltese: Għal xi prodotti, il-kontro-indikazzjonijiet jistgħu jkunu aktar rilevanti meta ritonavir jintuża bħala aġent antiretrovirali milli meta ritonavir jintuża biex iżid l-effett farmakokinetiku (e.ż. rifabutin u voriconazole):
English: Ritonavir Mylan can cause dizziness.
Maltese: Ritonavir Mylan jista' jikkawża sturdament.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer to the relevant product information for these medicinal products.
Maltese: F'kaz ta' terapija konkomitanti antiretrovirali għall-epatite B jew C, jekk jogħġbok irreferi għallinformazzjoni dwar il-prodott relatat ma' dawn il-prodotti mediċinali.
English: When ritonavir is used as a pharmacokinetic enhancer of other PIs, consult the Summary of Product Characteristics of the co-administered protease inhibitor for contraindications.
Maltese: Meta ritonavir jiġi użat ma impedituri tal-protejaż oħra biex iżid l-effett farmakokinetiku, għandu jiġi kkonsultat is-sommarju tal-karatteristiċi tal-impeditur tal-protejaż partikolari.
English: Adverse reactions from clinical trials and post-marketing experience in adult patients The most frequently reported adverse drug reactions among patients receiving ritonavir alone or in combination with other antiretroviral drugs were gastrointestinal (including diarrhoea, nausea, vomiting, abdominal pain (upper and lower)), neurological disturbances (including paraesthesia and oral paraesthesia) and fatigue/asthenia.
Maltese: L-aktar reazzjonijiet avversi tal-mediċina rrapurtati b'mod frekwenti fost pazjenti li qed jirċievu ritonavir biss jew ritonavir flimkien ma' mediċini antiretrivirali oħra kienu disturbi gastrointestinali (li jinkludu dijarea, nawseja, rimettar, uġigħ addominali (fil-parti ta' fuq u fil-parti t'isfel)), disturbi newroloġiċi (li jinkludu parasteżija u parasteżija madwar il-ħalq) u għeja/astenja.
English: 100q12h ↓ 22% ↓ 21%
Maltese: Didanosine ↓ 13% ↔
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of cyclosporine, tacrolimus or everolimus.
Maltese: Ritonavir dożat biex iżid l-effett farmakokinetiku jew bħala aġent antiretrovirali jimpedixxi CYP3A4 u għalhekk huwa mistenni li jżid ilkonċentrazzjoni fil-plażma ta' cyclosporine, tacrolimus jew everolimus.
English: 10, single dose 600q12h ↑ 153% ↑ 55% Inhibition of CYP3A and P-gp lead to increased plasma levels and pharmacodynamic effects of rivaroxaban which may lead to an increased bleeding risk.
Maltese: 100 q12 h Maraviroc ↑ 161% ↑ 28% Bħala riżultat ta' impediment minn CYP3A, ritonavir iżid il-livelli tas-serum ta' maraviroc.
English: Based on interaction studies with the ritonavir boosted protease inhibitors (lopinavir/ritonavir, atazanavir), concurrent administration of omeprazole or ranitidine does not significantly modify ritonavir efficacy as a pharmacokinetic enhancer despite a slight change of exposure (about 6 - 18%).
Maltese: Skond studji li saru fuq l-interazzjoni mal-impedituri protejaż li huma msaħħa b'ritonavir (lopinavir/ritonavir, atazanavir), l-għoti flimkien ta' omeprazole jew ranitidine, minkejja li jkun hemm bidla żgħira flesponiment (madwar 6 - 18%), ma jbiddilx l-effikaċja ta' ritonavir bħala li jżid l-effett farmakokinetiku b'mod sinifikanti.
English: Repeated dose toxicity studies in animals identified major target organs as the liver, retina, thyroid gland and kidney.
Maltese: Studji ripetuti dwar tossiċità fil-bhejjem identifikaw bħala l-organi prinċipali li jistgħu jiġu milquta bħala l-fwied, ir-retina, l-glandola tat-tirojde u l-kilwa.
English: Smoke cessation Buproprion
Maltese: Waqfien mit-tipjip Bupropion
English: Concomitant use of avanafil or vardenafil with ritonavir is contraindicated (see section 4.3).
Maltese: L-użu flimkien ta' avanafil ma' ritonavir huwa kontra-indikat (ara sezzjoni 4.3).
English: Serum concentrations may be increased due to CYP3A4 inhibition by ritonavir.
Maltese: Bħala riżultat ta' impediment minn CYP3A4, ritonavir iżid il-livelli tas-serum ta' indinavir.
English: Concomitant use of ritonavir (400 mg twice daily and more) and voriconazole is contraindicated due to a reduction in voriconazole plasma concentrations and possible loss of effect (see section 4.5).
Maltese: L-użu ta'ritonavir (400 mg darbtejn kuljum jew aktar) flimkien ma' voriconazole huwa kontroindikat minħabba li jkun hemm tnaqqis filkonċentrazzjoni fil-plażma ta' voriconazole, u għalhekk huwa possibbli li jintilef l-effett (ara sezzjoni 4.5)
English: Amprenavir 600 mg twice daily with ritonavir 100 mg twice daily.
Maltese: 100 mg darbtejn kuljum200 mg darba kuljum200 mg darbtejn kuljum
English: The metabolism of pravastatin and fluvastatin is not dependent on CYP3A, and interactions are not expected with ritonavir.
Maltese: Il-metaboliżmu ta' pravastatin u fluvastatin ma jiddependix fuq CYP3A, u m'humiex mistennija interazzjonijiet ma' ritonavir.
English: Zidovudine
Maltese: Pożoloġija
English: Ritonavir Mylan is used by children 2 years of age or older, adolescents and adults who are infected with HIV, the virus which causes AIDS.
Maltese: Ritonavir Mylan jintuża fit-tfal li għandhom sentejn jew aktar, fl-adolexxenti u fl-adulti li huma infettati bl-HIV, il-virus li jikkawża l-AIDS.
English: Antiarrhythmics Amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, quinidine
Maltese: Mediċini li jaħdmu fuq ir-rittmu tat-tħabbit tal-qalb Amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, quinidine
English: A large amount (6100 live births) of pregnant women were exposed to ritonavir during pregnancy; of these, 2800 live births were exposed during the first trimester.
Maltese: Ammont kbir (6100 ta' twelid ħaj) ta' nisa tqal ġew esposti għal ritonavir waqt it-tqala; minn dawn, 2800 ta' twelid ħaj kienu esposti waqt l-ewwel tliet xhur tat-tqala.