FrancophonIA/ELRC3.0 huggingface dataset:
English: Pull back on the pink safety cover toward the syringe and away from the needle.
Croatian: Povucite ružičasti zaštitni mehanizam unatrag prema štrcaljki, dalje od igle.
English: Cases of thromboembolic events (TEEs), including portal vein thrombosis, have been reported in patients with chronic liver disease receiving romiplostim.
Croatian: Slučajevi tromboembolijskih događaja, uključujući trombozu vene porte, su prijavljeni u bolesnika s kroničnom jetrenom bolesti koji su primali romiplostim.
English: Platelet counts should be assessed monthly thereafter and appropriate dose adjustments made as per the dose adjustment table (table 2) in order to maintain platelet counts within the recommended range.
Croatian: Nakon toga se broj trombocita mora kontrolirati jednom mjesečno, a doza prilagoditi prema smjernicama o prilagodbi doze (tablica 2) kako bi se broj trombocita zadržao unutar preporučenog raspona.
English: Injection Site
Croatian: Mjesta za injekciju
English: The elimination of serum romiplostim is in part dependent on the TPO receptor on platelets.
Croatian: Eliminacija serumskog romiplostima je djelomično ovisno o receptorima za TPO na trombocitima.
English: SPECIAL PRECAUTIONS FOR DISPOSAL OF UNUSED MEDICINAL PRODUCTS OR WASTE MATERIALS DERIVED FROM SUCH MEDICINAL PRODUCTS, IF APPROPRIATE
Croatian: 10. posebne mjere za zbrinjavanje neiskorištenog lijeka ili OTPADNIH MATERIJALA KOJI POTJEČU
English: Immediately prepare new syringe for injection.
Croatian: Odmah pripremite novu štrcaljku za injekciju.
English: Blood pressure increased Blood lactate dehydrogenase increased
Croatian: Povišeni krvni tlak Povišena laktat dehidrogenaza u krvi
English: There were no antibodies detected to TPO.
Croatian: Nisu potvrđena protutijela na TPO.
English: Reconstitute lyophilised product as described in section 6.6.
Croatian: Rekonstituirati liofilizirani lijek kako je opisano u dijelu 6.6.
English: c Number of weeks with platelet response is defined as number of weeks with platelet counts ≥ 50 x 109/L during study weeks 2-25.
Croatian: c Broj tjedana s odgovorom trombocita definiran je kao broj tjedana s brojem trombocita ≥ 50 x 109/l za razdoblje od 2. do 25. tjedna ispitivanja.
English: Underdose may result in lower than expected platelet counts and potential for bleeding.
Croatian: Subdoziranje može uzrokovati manji broj trombocita od očekivanog i moguće krvarenje.
English: 4 vials.
Croatian: 4 bočice.
English: Portal vein thrombosis Increase in transaminase
Croatian: Tromboza vene porte Povišenje transaminaza
English: Some of the adverse reactions seen in adults were reported more frequently in paediatric subjects such as cough, diarrhoea, rash, pyrexia and contusion reported very commonly (≥ 1/10) in paediatric subjects and purpura and urticaria were reported commonly (≥ 1/100 to < 1/10) in paediatric subjects.
Croatian: Neke od nuspojava primijećenih u odraslih prijavljene su češće u pedijatrijskih bolesnika, kao što su kašalj, proljev, osip, pireksija i kontuzija koje su prijavljene vrlo često (≥ 1/10) u pedijatrijskih bolesnika te purpura i urtikarija koje su prijavljene često (≥ 1/100 i < 1/10) u pedijatrijskih bolesnika.
English: • blood clot in a lung artery (pulmonary embolism);
Croatian: • krvni ugrušak u plućnoj arteriji (plućna embolija);
English: In the subset of subjects with ITP > 12 months of duration, the overall subject incidence of platelet response was 93.7% (n = 59) and was similar across age groups.
Croatian: U podskupini bolesnika s ITP-om u trajanju od > 12 mjeseci, ukupna incidencija odgovora trombocita u ispitanika bila je 93,7% (n = 59) i bila je slična za sve dobne skupine.
English: The median (Q1, Q3) average weekly dose was 4.82 mcg/kg (1.88 mcg/kg, 8.79 mcg/kg).
Croatian: Medijan (Q1, Q3) prosječne tjedne doze bio je 4,82 µg/kg (1,88 µg/kg, 8,79 µg/kg).
English: Remove the plastic cap from Nplate powder vial and clean rubber stopper using the provided alcohol swab.
Croatian: Uklonite plastični poklopac s bočice s praškom Nplate i očistite gumeni čep pomoću priložene vatice natopljene alkoholom.
English: Multiple myeloma Myelofibrosis
Croatian: Multipli mijelom Mijelofibroza
English: Nplate should be injected once per week in order to keep your platelet counts up.
Croatian: Nplate se mora ubrizgati jednom tjedno kako biste zadržali veći broj trombocita.
English: • fever (pyrexia);
Croatian: • vrućica (pireksija);
English: • Clean the flat work surface with a new alcohol swab.
Croatian: • Očistite ravnu radnu površinu novom vaticom natopljenom alkoholom.
English: Instructions for preparing and giving an injection of Nplate
Croatian: Upute za pripremu i davanje injekcije lijeka Nplate
English: If you have very high blood platelet counts this may increase the risk of blood clotting.
Croatian: Ako imate vrlo visok broj trombocita, povećava se rizik od zgrušavanja krvi.
English: If you have questions about how to inject, please ask your doctor, nurse or pharmacist for assistance.
Croatian: Ako imate pitanja o tome kako ubrizgati lijek, molimo da se obratite liječniku, medicinskoj sestri ili ljekarniku za pomoć.
English: Study S2 (105) evaluated patients who were splenectomised and continued to have thrombocytopenia.
Croatian: U ispitivanje S2 (105) uključeni su bolesnici koji su nakon splenektomije i dalje imali trombocitopeniju.
English: In 6 additional patients reticulin was observed upon bone marrow biopsy (see section 4.4).
Croatian: U 6 dodatnih bolesnika odlaganje retikulina je uočeno kod biopsije koštane srži (vidjeti dio 4.4).
English: After subcutaneous administration of 3 to 15 mcg/kg romiplostim, maximum romiplostim serum levels in ITP patients were obtained after 7-50 hours (median 14 hours).
Croatian: Nakon supkutane primjene od 3 do 15 µg/kg romiplostima, maksimalna serumska razina romiplostima u bolesnika s ITP-om postignuta je nakon 7 do 50 sati (medijan 14 sati).
English: Medication errors including overdose and underdose have been reported in patients receiving Nplate, dose calculation and dose adjustment guidelines should be followed (see section 4.2).
Croatian: Prijavljeni su slučajevi medikacijskih pogrešaka uključujući predoziranje i subdoziranje u bolesnika u kojih se primijenio Nplate, potrebno je slijediti smjernice o izračunu doze, te prilagodbi doze (vidjeti dio 4.2).
English: Pruritus Ecchymosis Rash
Croatian: Pruritus Ekhimoze Osip
English: This non-linear decrease in volume of distribution is in line with the (megakaryocyte and platelet) target-mediated binding of romiplostim, which may be saturated at the higher doses applied.
Croatian: To nelinearno smanjenje volumena distribucije u skladu je s ciljno posredovanim (megakariociti i trombociti) vezanjem romiplostima, pri čemu se javlja zasićenost receptora kod primjene većih doza.
English: The most frequently used weekly dose was between 3-5 mcg/kg (25th-75th percentile respectively; median 3 mcg/kg).
Croatian: Najčešće primjenjivana tjedna doza bila je između 3 i 5 µg/kg (25. do 75. percentil; medijan 3 µg/kg).
English: Gently tap the syringe with your fingers to separate the bubbles from the liquid.
Croatian: Nježno kucnite o štrcaljku prstima kako biste odvojili mjehuriće od tekućine.
English: A significantly higher proportion of patients receiving romiplostim achieved a durable platelet response compared to patients receiving placebo in both studies.
Croatian: Značajno veći udio bolesnika koji su primali romiplostim je postigao dugotrajni porast broja trombocita u usporedbi s onima koji su primali placebo u oba ispitivanja.
English: • Step 3a: Attach clear plastic plunger rod to pre-filled sterile water syringe by placing the threaded end of the plunger rod into the syringe and carefully twisting the rod clockwise onto the grey syringe plunger, until you feel a slight resistance.
Croatian: • Korak 3a: Spojite prozirni plastični klip s napunjenom štrcaljkom sa sterilnom vodom tako što ćete uvesti navojni kraj klipa u štrcaljku i pažljivo ga zakrenuti u smjeru kazaljke na satu na sivi čep za klip u štrcaljki, sve dok ne osjetite blagi otpor.
English: If you have been given more Nplate than you should, you may not experience any physical symptoms but your blood platelet counts may rise to very high levels and this may increase the risk of blood clotting.
Croatian: Ako Vam je dano više lijeka Nplate nego što treba, ne biste trebali doživjeti nikakve fizičke simptome, no broj trombocita može porasti do vrlo visoke vrijednosti, i to može povećati rizik zgrušavanja krvi.
English: If individual patient dose is ≥ 23 mcg
Croatian: Ako je individualna doza za bolesnika ≥ 23 µg
English: • Do not rub the injection site.
Croatian: • Nemojte trljati mjesto ubrizgavanja.
English: Do ensure that the plunger remains in the syringe.
Croatian: Pazite da klip ostane u štrcaljki.
English: • swelling in the hands and feet (oedema peripheral);
Croatian: • oticanje ruku i stopala (periferni edem);
English: Plunger rod for pre-filled sterile water syringe x1 Pre-filled sterile water syringe x1
Croatian: Klip za napunjenu štrcaljku sa sterilnom vodomx1 Napunjenu štrcaljku sa sterilnom vodom x1
English: In a prenatal and postnatal development study in rats an increase of the duration of gestation and a slight increase in the incidence of peri-natal pup mortality was found.
Croatian: U prenatalnim i postnatalnim razvojnim ispitivanjima u štakora zabilježeno je produljeno trajanje gestacije te blagi porast incidencije perinatalne smrtnosti potomaka.
English: • Once all air bubbles are removed and syringe is filled with your correct dose, twist off syringe from vial adapter.
Croatian: • Nakon što svi mjehurići zraka budu uklonjeni i u štrcaljki se nalazi ispravna doza, zakretanjem odvojite štrcaljku od nastavka za bočicu.
English: Reconstitute lyophilised product and then dilute the product as described in section 6.6.
Croatian: Rekonstituirati liofilizirani lijek i zatim razrijediti lijek kako je opisano u dijelu 6.6.
English: Patients (≥ 18 years) were randomised in a 2:1 ratio to receive a starting dose of romiplostim 1 mcg/kg or placebo.
Croatian: Bolesnici (≥ 18 godina) su randomizirani (omjer 2 : 1) ili da dobiju početnu dozu romiplostima 1 µg/kg ili placebo.
English: A clinically significant bleeding event was defined as a Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 grade ≥ 2 bleeding event.
Croatian: Common Terminology Criteria for Adverse Events, CTCAE), verzija 3.0, kao događaj krvarenja stupnja ≥ 2.
English: If you have been given less Nplate than you should, you may not experience any physical symptoms but your blood platelet counts may become low and this may increase the risk of bleeding.
Croatian: Ako Vam je dano manje lijeka Nplate nego što treba, ne biste trebali doživjeti nikakve fizičke simptome, no broj trombocita može se smanjiti i tako povećati rizik od krvaranja.
English: The pharmacokinetics of romiplostim involved target-mediated disposition, which is presumably mediated by TPO receptors on platelets and other cells of the thrombopoietic lineage such as megakaryocytes.
Croatian: Na farmakokinetiku romiplostima utjecala je raspoloživost ciljnih molekula, za koju se pretpostavlja da je posredovana TPO receptorima na trombocitima i drugim stanicama trombocitne loze, kao što su megakariociti.
English: Across all subjects, the median (Q1, Q3) percentage of months with platelet response was 93.33% (67.57%, 100.00%) and was similar across age groups.
Croatian: Za sve bolesnike, medijan (Q1, Q3) postotka mjeseci s odgovorom trombocita bio je 93,33% (67,57%, 100,00%) i bio je sličan za sve dobne skupine.
English: Seventy-three percent of non-splenectomised patients receiving romiplostim were able to reduce the dose by more than 25% or discontinue concurrent ITP medical therapies by the end of the study compared to 50% of placebo treated patients (see section 4.5).
Croatian: 73% nesplenektomiranih bolesnika koji su primali romiplostim bilo je u mogućnosti smanjiti dozu za više od 25%, ili prekinuti dotadašnju terapiju drugim lijekovima za ITP do kraja ispitivanja, što je bio slučaj u 50% bolesnika liječenih placebom (vidjeti dio 4.5).
English: The risk of blood clotting may also be increased if you: have liver problems; are elderly (≥ 65 years); are bedridden; have cancer; are taking the contraceptive pill or hormone replacement therapy; have recently had surgery or suffered an injury; are obese (overweight); are a smoker.
Croatian: Rizik za zgrušavanje krvi može biti povećan i ako: imate tegobe s jetrom, ste u starijoj životnoj dobi (≥ 65 godina), ste nepokretni i vezani uz krevet, imate rak, uzimate kontracepcijske tablete ili hormonsku nadomjesnu terapiju, ste nedavno bili na operaciji ili ste se ozlijedili, ste pretili (imate povećanu tjelesnu težinu), pušite.
English: Concurrent anaemia and leucocytosis (within a 4-week window) may occur in patients regardless of splenectomy status, but have been seen more often in patients who have had a prior splenectomy.
Croatian: Bez obzira na status splenektomije, u bolesnika može doći do istodobne anemije ili leukocitoze (unutar razdoblja od 4 tjedna), ali one su češće zamijećene u bolesnika u kojih je prethodno provedena splenektomija.
English: A summary of the key efficacy endpoints is presented below.
Croatian: Sažetak glavnih ishoda djelotvornosti nalazi se u tablici ispod.
English: • Do not roll vial between palms.
Croatian: • Nemojte trljati bočicu između dlanova.
English: In another ITP clinical trial, no accumulation in serum concentrations was observed after 6 weekly doses of romiplostim (3 mcg/kg).
Croatian: U drugom kliničkom ispitivanju ITP-a nije uočen porast koncentracija u serumu nakon 6 tjednih doza romiplostima (3 µg/kg).
English: * see section 4.4 ** Hypersensitivity reactions including cases of rash, urticaria, and angioedema
Croatian: *vidjeti dio 4.4 ** Reakcije preosjetljivosti uključujući slučajeve osipa, urtikarije i angioedema.
English: Prior treatments included corticosteroids (90% of all patients), immunoglobulins (76%), rituximab (29%), cytotoxic therapies (21%), danazol (11%), and azathioprine (5%).
Croatian: Prijašnja liječenja uključuju kortikosteroide (90% svih bolesnika), imunoglobuline (76%), rituksimab (29%), kemoterapiju (21%), danazol (11%) i azatioprin (5%).
English: Check the expiry date on the self injection kit.
Croatian: Provjerite istek roka valjanosti na priboru za samoubrizgavanje.
English: • In adults, future dose adjustments are based on changes in platelet counts only.
Croatian: • U odraslih bolesnika, sljedeće prilagodbe doze temelje se samo na promjenama broja trombocita.
English: Volume to administer (mL) = 10 mcg / 125 mcg/mL = 0.08 mL
Croatian: Volumen za primjenu (ml) = 10 µg/ 125 µg/ml = 0,08 ml
English: Nplate is administered once a week as an injection under the skin (subcutaneous).
Croatian: Nplate se primjenjuje jednom tjedno kao potkožna injekcija (supkutano).
English: The most common adverse reactions in paediatric ITP patients 1 year and older were upper respiratory tract infection, rhinitis, cough, oropharyngeal pain, upper abdominal pain, diarrhoea, rash, pyrexia, contusion (reported very commonly (≥ 1/10)), and pharyngitis, conjunctivitis, ear infection, gastroenteritis, sinusitis, purpura, urticaria and peripheral swelling (reported commonly (≥ 1/100 to
Croatian: Najčešće nuspojave u pedijatrijskih bolesnika s ITP-om u dobi od 1 godine i starijih bile su infekcija gornjeg respiratornog trakta, rinitis, kašalj, orofaringealna bol, bol u gornjem dijelu abdomena, proljev, osip, pireksija, kontuzija (prijavljeno vrlo često (≥ 1/10)) te faringitis, konjunktivitis, infekcija uha, gastroenteritis, sinusitis, purpura, urtikarija i periferno oticanje (prijavljeno često (≥ 1/100 i
English: 75 mcg x
Croatian: 75 µg x
English: No statistically significant differences in the overall incidence of bleeding events were observed between Nplate and placebo treated patients.
Croatian: Nije bilo statistički značajne razlike u ukupnoj incidenciji događaja krvarenja između bolesnika liječenih Nplateom ili placebom.
English: • inflammation of the sinuses (sinusitis);
Croatian: • upala sinusa (sinusitis);
English: In study S4, 62 subjects were randomised in a 2:1 ratio to receive romiplostim (n = 42) or placebo (n = 20) and stratified into 1 of 3 age cohorts.
Croatian: U ispitivanju S4, 62 bolesnika bila su randomizirana u omjeru 2:1 za primanje romiplostima (n = 42) ili placeba (n = 20) i raspoređena u 1 od 3 dobne kohorte.
English: Medication errors including overdose and underdose have been reported in patients receiving Nplate, dose calculation and dose adjustment guidelines should be followed.
Croatian: Prijavljeni su slučajevi medikacijskih pogrešaka uključujući predoziranje i subdoziranje u bolesnika u kojih se primijenio Nplate; potrebno je slijediti smjernice o izračunu doze te prilagodbi doze.
English: Of those 62 subjects, 48 subjects had ITP > 12 months of duration (32 subjects received romiplostim and 16 subjects received placebo).
Croatian: Od ova 62 bolesnika, 48 bolesnika je imalo ITP u trajanju od > 12 mjeseci (32 bolesnika je primalo romiplostim, a 16 bolesnika je primalo placebo).
English: Summary of key efficacy results from placebo-controlled studies
Croatian: Sažetak o djelotvornosti prema rezultatima placebo kontroliranih ispitivanja
English: In the subset of subjects with ITP > 12 months of duration, the incidence of durable response was also significantly greater in the romiplostim arm compared with the placebo arm (p = 0.0022).
Croatian: U podskupini bolesnika s ITP-om u trajanju od > 12 mjeseci, incidencija dugotrajnog odgovora bila je također značajno veća u skupini na romiplostimu u usporedbi sa skupinom na placebu (p = 0,0022).
English: • higher than normal platelet counts (thrombocytosis);
Croatian: • broj trombocita veći od normalnih vrijednosti (trombocitoza);
English: Platelet counts should be monitored when combining romiplostim with other medicinal products for the treatment of ITP in order to avoid platelet counts outside of the recommended range (see section 4.2).
Croatian: Mora se pratiti broj trombocita kod istodobne primjene romiplostima s drugim lijekovima za liječenje ITP-a, kako bi se izbjeglo da broj trombocita bude izvan preporučenog intervala (vidjeti dio 4.2).
English: There was also a stimulatory effect on leukocyte production, as peripheral blood counts for neutrophils, lymphocytes, monocytes, and eosinophils were mildly increased.
Croatian: Opažen je i stimulacijski učinak na stvaranje leukocita, jer je broj neutrofila, limfocita, monocita i eozinofila u perifernoj krvi bio blago povećani.
English: • muscles pain or weakness (myalgia);
Croatian: • bol ili slabost mišića (mialgija);
English: • pain in the mouth and throat (oropharyngeal pain);
Croatian: • bol u ustima i grlu (orofaringealna bol);
English: In Study S6 (340), intensive romiplostim concentrations were available from 4 subjects (2 at 7 mcg/kg and 2 at 9 mcg/kg).
Croatian: U ispitivanju S6 (340), koncentracije romiplostima kod intenzivnog mjerenja bile su raspoložive za 4 bolesnika (2 s dozom od 7 µg/kg i 2 s dozom od 9 µg/kg).
English: The median average weekly dose for splenectomised patients was 3 mcg/kg and for non-splenectomised patients was 2 mcg/kg.
Croatian: Medijan prosječne tjedne doze u splenektomiranih bolesnika bio je 3 µg/kg, a u nesplenektomiranih 2 µg/kg.
English: • heart attack (myocardial infarction); increased heart rate;
Croatian: • srčani udar (infarkt miokarda); ubrzani rad srca;
English: Action Increase once weekly dose by 1 mcg/kg
Croatian: Povećati tjednu dozu za 1 µg/kg
English: All (100%) splenectomised patients who were receiving romiplostim were able to reduce the dose by more than 25% or discontinue the concurrent ITP medical therapies by the end of the treatment period compared to 17% of placebo treated patients.
Croatian: Svi (100%) splenektomirani bolesnici koji su primali romiplostim bili su u mogućnosti smanjiti dozu tih drugih lijekova za ITP za više od 25%, ili su ih čak prekinuli uzimati do kraja liječenja, što je bio slučaj sa samo 17% bolesnika koji su dobivali placebo.
English: Draw air into syringe to the 1 mL mark
Croatian: Uvucite zrak u štrcaljku do oznake 1 ml.
English: Single-dose vial (type 1 clear glass) with a stopper (chlorobutyl rubber), seal (aluminium) and a flip-off cap (polypropylene).
Croatian: Jednodozna bočica (prozirno staklo tipa 1) s čepom (klorobutilna guma), prstenom (aluminij) i flip-off kapicom (polipropilen).
English: Do not use this medicine after the expiry date which is stated on the vial label after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici bočice iza EXP.
English: • influenza; localised infection; inflammation of the passages in the nose and throat (nasopharyngitis);
Croatian: • gripa; lokalizirana infekcija; upala nosne šupljine i grla (nazofaringitis);
English: • changes in some blood tests (increase in transaminase; blood lactate dehydrogenase increased);
Croatian: • promjene u pojedinim krvnim laboratorijskim nalazima (porast jetrenih enzima/transaminaza,
English: A vial of powder, either 250 micrograms OR 500 micrograms x1
Croatian: Bočicu s praškom od 250 mikrograma ILI 500 mikrograma x1
English: Of those 22 subjects, 17 subjects had ITP > 12 months of duration (14 subjects received romiplostim and 3 subjects received placebo).
Croatian: Od ova 22 bolesnika, 17 bolesnika je imalo ITP u trajanju od > 12 mjeseci (14 bolesnika je primalo romiplostim, a 3 bolesnika su primala placebo).
English: If you experience a loss of response or failure to maintain a platelet response with romiplostim treatment, your doctor will investigate the reasons why including whether you are experiencing increased bone marrow fibres (reticulin) or have developed antibodies which neutralise romiplostim's activity.
Croatian: Ako tijekom primjene lijeka dođe do gubitka terapijskog učinka romiplostima, ili nije moguće održati odgovarajući broj trombocita, Vaš liječnik će istražiti uzroke, uključujući i mogućnost da je došlo do povećanja vlakana (retikulina) u koštanoj srži ili da razvijate protutijela koja neutraliziraju aktivnost romiplostima.
English: • swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing (angioedema);
Croatian: • oticanje lica, usana, usta, jezika ili grla, što može uzrokovati otežano gutanje ili disanje
English: Prepare injection site with a new alcohol swab.
Croatian: 13. Pripremite mjesto za injekciju pomoću nove vatice natopljene alkoholom.
English: The vial should not be shaken or vigorously agitated.
Croatian: Bočica se ne smije tresti niti snažno mućkati.
English: After a single subcutaneous dose of 1 to 10 mcg/kg romiplostim in ITP patients, the peak platelet count was 1.3 to 14.9 times greater than the baseline platelet count over a 2 to 3 week period and the response was variable among patients.
Croatian: Nakon jedne supkutane doze od 1 do 10 µg/kg romiplostima u bolesnika s ITP-om, vršni broj trombocita bio je 1,3 do 14,9 puta veći nego početni broj trombocita tijekom 2 do 3 tjedna, a terapijski odgovor varirao je od bolesnika do bolesnika.
English: If you stop using Nplate
Croatian: • Ako prestanete uzimati
English: It must be clear and colourless and fully dissolved.
Croatian: Mora biti bistra i bezbojna, a prašak mora biti potpuno otopljen.
English: A decision on whether to discontinue breast-feeding or discontinue therapy with romiplostim should be made taking into account the benefit of breast-feeding to your child and the benefit of romiplostim therapy to you.
Croatian: Odluka o prestanku dojenja ili prekidu terapije romiplostimom mora se donijeti uzimajući u obzir korist dojenja za Vaše dijete, odnosno korist liječenja romiplostimom za Vas.