FrancophonIA/ELRC3.0 huggingface dataset:
English: If overdose occurs the patient should be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Croatian: Ukoliko dođe do predoziranja, potrebno je nadzirati bolesnika kako bi se uočili znakovi toksičnosti (vidjeti dio 4.8), kao i primijeniti uobičajene mjere suportivnog liječenja ukoliko se za to ukaže potreba.
English: Remember to tell your doctor or pharmacist if you begin taking a new medicine while you are taking Kivexa.
Croatian: Zapamtite da svakako obavijestite svog liječnika ili ljekarnika ako započnete uzimati nove lijekove dok uzimate istodobno lijek Kivexa.
English: This indicates a low likelihood for interactions with other medicinal products through plasma protein binding displacement.
Croatian: To ukazuje na malu vjerojatnost interakcije s drugim lijekovima zbog potiskivanja s mjesta vezanja na proteine plazme.
English: Among the 104 patients who received Kivexa, including the ones who were between 40 kg and 25 kg, the viral suppression was similar
Croatian: U 104 bolesnika koji su primili lijek Kivexa, uključujući one s tjelesnom težinom između 40 i 25 kg supresija virusa je bila slična.
English: Therefore, there is little potential for interactions with antiretroviral protease inhibitors, non-nucleosides and other medicinal products metabolised by major P450 enzymes.
Croatian: Stoga postoji mala mogućnost za interakcije lijeka s antiretrovirusnim inhibitorima proteaze, nenukleozidima te drugim lijekovima koji se metaboliziraju pomoću glavnih P450 enzima.
English: In these cases the physician should refer to the individual product information for these medicinal products.
Croatian: U tim slučajevima liječnik mora proučiti individualne sažetke opisa svojstava lijeka za te lijekove.
English: For many of these adverse reactions it is unclear whether they are related to the active substance, the wide range of other medicinal products used in the management of HIV infection, or whether they are a result of the underlying disease process.
Croatian: U mnogim slučajevima nije sasvim jasno jesu li one povezane s djelatnim tvarima, velikim brojem lijekova koji se koriste u liječenju HIV infekcije ili su posljedica podležeće bolesti.
English: Abacavir increases the rate at which methadone is removed from the body.
Croatian: Abakavir povećava brzinu kojom se metadon uklanja iz organizma.
English: These belong to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Croatian: One pripadaju skupini antiretrovirusnih lijekova, nazvanih inhibitorima reverzne transkriptaze analoga nukleozida (NRTI).
English: Studies in animals showed that neither abacavir nor lamivudine had any effect on fertility (see section
Croatian: Studije na životinjama su pokazale da niti abakavir niti lamivudin nemaju nikakav učinak na fertilitet (vidjeti dio 5.3)
English: Combivir is a fixed dose combination of lamivudine and zidovudine 2.
Croatian: Combivir je fiksna kombinacija lamivudina i zidovudina
English: Continued passage in increasing concentrations of drug resulted in selection for double RT mutants 65R/184V and 74V/184V or triple RT mutant 74V/115Y/184V.
Croatian: Daljnji prolazak sa povećavanjem koncentracije lijeka rezultirao je selekcijom dvostrukih RT mutacija 65R/184V i 74V/184V ili trostrukih mutacija 74V/115Y/184V.
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Croatian: Bolesnicima treba savjetovati da se jave liječniku ako primijete bolove u zglobovima, ukrućenost zglobova ili poteškoće prilikom kretanja.
English: Key elements included in the educational material to increase understanding and awareness of ABC HSR and expand on the information already included in the currently approved EU SPC:
Croatian: Ključne poruke uključene u edukacijske materijale kako bi se poboljšalo razumijevanje i povećala svijest o ABC HSR te proširile informacije već uključene u trenutno odobreni EU
English: Pharmacotherapeutic group: Antivirals for systemic use, antivirals for treatment of HIV infections, combinations.
Croatian: Farmakoterapijska skupina: Antivirotici za sistemsko liječenje, antivirotici za terapiju HIV-a, kombinacije.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskim stranicama Europske agencije za lijekove http://www.ema.europa.eu
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP) koji se nalazi u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: These were primarily asymptomatic HIV infected patients (CDC stage A).
Croatian: HIV infekcijom (CDC stadij A).
English: Kivexa is a fixed-dose tablet and should not be prescribed for patients requiring dose adjustments.
Croatian: Kivexa je kombinacija fiksnih doza i ne smije se propisivati bolesnicima kojima je potrebno prilagođavanje doze.
English: If you have stopped taking Kivexa for any reason - especially because you think you are having side effects, or because you have other illness:
Croatian: Ako ste prekinuli uzimati lijek Kivexa zbog bilo kojeg razloga - posebice zato što mislite da imate nuspojave ili neku drugu bolest:
English: Data from clinical trials showed limited numbers of myocardial infarction and could not exclude a small increase in risk.
Croatian: Podaci kliničkih istraživanja su pokazali ograničen broj infarkta miokarda u tih pacijenata, stoga se nije mogao isključiti mali porast rizika.
English: Kivexa contains two active ingredients that are used to treat HIV infection: abacavir and lamivudine.
Croatian: Kivexa sadrži dvije djelatne tvari koje se koriste u liječenju HIV infekcija: abakavir i lamivudin.
English: • aches and pains (especially in the hip, knee or shoulder)
Croatian: • stalna tupa bol i povremeni bolovi (posebice u kuku, koljenu ili ramenu)
English: Insufficient data to recommend dosage adjustment.
Croatian: Nedostatni podaci koji bi preporučili prilagodbu doze.
English: Phenotypic resistance and cross-resistance
Croatian: Fenotipska rezistencija i križna rezistencija
English: Four or more NRTIassociated mutations 28
Croatian: Četiri ili više mutacija povezanih s NRTI
English: Do not stop taking Kivexa unless your doctor advises you to do so.
Croatian: Nemojte prestajati uzimati lijek Kivexa, osim ako Vam to nije savjetovao liječnik.
English: Number of subjects with ≥1 Thymidine Analogue Mutations (TAMs).
Croatian: Broj bolesnika s ≥1 mutacijom analoga timidina (TAMs, "Thymidine Analogue Mutations").
English: Clinical studies have shown that there are no clinically significant interactions between abacavir and lamivudine.
Croatian: Klinička ispitivanja pokazala su da nema klinički značajnih interakcija između abakavira i lamivudina.
English: The GSS was obtained from the Monogram reports with susceptible virus ascribed the values ‘1-4' based upon the numbers of drugs in the regimen and with virus with reduced susceptibility ascribed the value ‘0'.
Croatian: GSS dobiven je iz Monogramskih izvještaja na način da se osjetljivim virusima temeljem broja lijekova u režimu dodijelila vrijednost "1-4", a virusima sa smanjenom osjetljivošću dodijeljena je vrijednost "0".
English: Two mutations conferred a 7- to 8-fold change in abacavir susceptibility and combinations of three mutations were required to confer more than an 8-fold change in susceptibility.
Croatian: Dvije mutacije su doprinijele promjeni osjetljivosti na abakavir 7 do 8 puta, a u kombinacija od tri mutacije je bila potrebna za promjenu osjetljivosti na abakavir veću od 8 puta.
English: The absolute bioavailability of oral abacavir and lamivudine in adults is about 83% and 80-85% respectively.
Croatian: Apsolutna bioraspoloživost oralnog oblika abakavira u odraslih iznosi oko 83%, a lamivudina 80-85%.
English: HLA-B*5701 is the only identified pharmacogenetic marker that is consistently associated with clinical diagnosis of an ABC HSR reaction.
Croatian: HLA-B*5701 je jedini identificirani farmakogenetski marker koji se dosljedno povezuje s kliničkom dijagnozom ABC HSR reakcije.
English: Separate preparations of abacavir or lamivudine are available in cases where discontinuation or dose adjustment of one of the active substances is indicated.
Croatian: Postoje odvojeni pripravci lamivudina i abakavira za slučajeve kada je potrebno ukidanje ili prilagođavanje doze jedne od djelatnih tvari.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jirovecii pneumonia (often referred to as PCP).
Croatian: Relevantni primjeri uključuju citomegalovirusom izazvani retinitis, generalizirane i/ili fokalne infekcije mikobakterijama i pneumoniju izazvanu s Pneumocystis jirovecii (koja se često naziva PCP).
English: These medicines should not be used with Kivexa:
Croatian: Ovi lijekovi se ne smiju uzimati zajedno s lijekom Kivexa:
English: OTHER SPECIAL WARNING(S), IF NECESSARY Detach enclosed Alert Card, it contains important safety information WARNING!
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A), AKO JE POTREBNO Odvojite priloženu Karticu s upozorenjem, jer sadrži važne sigurnosne informacije
English: These findings should be considered for any child exposed in utero to nucleotide and nucleotide analogues, who presents with severe clinical findings of unknown etiology, particularly neurologic findings..
Croatian: Te nalaze treba uzeti u obzir u svakog djeteta koje je in utero bilo izloženo analozima nukleozida i nukleotida, a koje je imalo tešku kliničku sliku nepoznate etiologije, osobito neurološke nalaze.
English: - If you have any further questions ask your doctor or pharmacist.
Croatian: - Ako imate dodatnih pitanja, obratite se liječniku ili ljekarniku.
English: With the exception of a negative in vivo rat micronucleus test, there are no data available on the effects of the combination of abacavir and lamivudine in animals.
Croatian: S izuzetkom negativnog mikronukleusnog testa u štakora in vivo, nema dostupnih podataka o učincima kombinacije abakavira i lamivudina u životinja.
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited plasma protein binding in vitro (< 36%).
Croatian: Lamivudin pokazuje linearnu farmakokinetiku u rasponu terapijskih doza i ograničeno se veže za proteine u plazmi in vitro (< 36%).
English: There is no evidence from clinical studies that abacavir is hepatotoxic.
Croatian: Nema dokaza iz kliničkih ispitivanja koji bi ukazivali da je abakavir hepatotoksičan.
English: The IC50 for wild-type HXB2 is 0.24 to 0.6 µM, while the IC50 for M184V containing HXB2 is >100 to 500 µM.
Croatian: IC50 za divlji soj HXB2 bila je 0,24 do 0,6 µM, dok je IC50 za M184V koja sadrži HXB2 bila >100 do 500 µM.
English: Some people taking medicines for HIV infection develop other conditions, which can be serious.
Croatian: Neki ljudi koji uzimaju terapiju za liječenje HIV infekcije razvijaju i druga stanja koja mogu biti ozbiljna.
English: Each susceptible drug in the regimen received a score of 1 and drugs for which the ANRS algorithm predicts resistance were ascribed the value ‘0'.
Croatian: Svakom lijeku u režimu koji je osjetljiv, dodijeljen je indeks 1, a lijekovi za koje ANRS algoritam predviđa rezistenciju dobili su vrijednost "0".
English: Abacavir and its metabolites are excreted into the milk of lactating rats.
Croatian: Abakavir i njegovi metaboliti izlučuju se u mlijeko ženki štakora u laktaciji.
English: NAME OF THE MARKETING AUTHORISATION HOLDER ViiV Healthcare BV
Croatian: NAZIV NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET ViiV Healthcare BV
English: Data show that abacavir and lamivudine penetrate the central nervous system (CNS) and reach the cerebrospinal fluid (CSF).
Croatian: Podaci pokazuju da abakavir i lamivudin penetriraju u središnji živčani sustav (SŽS) i ulaze u cerebrospinalnu tekućinu (CST).
English: Analysis of the data from subjects in the low viral load stratum showed no demonstrable difference between the nucleoside backbones in the proportion of patients free of virological failure at week 96.
Croatian: Analiza podataka o bolesnicima s niskim viralnim opterećenjem nije pokazala značajne razlike između nukleozidnih osnova u odnosu na bolesnike bez izostanka virološkog odgovora u 96. tjednu.
English: The presence of M184V with Y115F gives rise to cross-resistance between abacavir and lamivudine.
Croatian: Prisustvo M184V s Y115F uzrokuje križnu rezistenciju između abakavira i lamivudina.
English: As a general rule, when deciding to use antiretroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account.
Croatian: Opće pravilo je, da se kod odluke za primjenom antiretrovirusnih lijekova za liječenje infekcije HIV-a u trudnica i posljedično tome za smanjenje rizika vertikalnog prijenosa HIV-a na novorođenčad, trebaju uzeti u obzir i podaci dobiveni na životinjama kao i klinička iskustva na trudnicama.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Croatian: Lamivudin nije pokazao teratogeni učinak u ispitivanjima na životinjama, ali bilo je znakova koji su ukazivali na porast rane smrtnosti embrija u zečeva pri relativno niskoj sistemskoj izloženosti usporedivoj s onom koja se postiže u ljudi.
English: • hair loss
Croatian: • gubitak kose.
English: Due to similarities, Kivexa should not be administered concomitantly with other cytidine analogues, such as emtricitabine.
Croatian: Kivexa se zbog sličnosti ne smije primjenjivati istodobno s drugim analozima citidina, poput emtricitabina.
English: Important information about some of the other ingredients of Kivexa tablets Kivexa contains a colouring called sunset yellow (E110), this may cause allergic reactions in some people.
Croatian: Važne informacije o nekim pomoćnim tvarima u Kivexa tabletama Kivexa sadrži bojilo pod nazivom “sunset yellow” (E110), koje može uzrokovati alergijske reakcije u nekih bolesnika.
English: Other key symptoms include gastrointestinal, respiratory or constitutional symptoms such as lethargy and malaise.
Croatian: Drugi glavni simptomi uključuju gastrointestinalne, respiratorne ili opće simptome poput letargije i malaksalosti.
English: HIV infection is spread by sexual contact with someone who has the infection, or by transfer of infected blood (for example, by sharing injection needles).
Croatian: HIV infekcija se širi putem spolnog kontakta s nekim tko ima infekciju ili putem zaražene krvi (npr.
English: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero Burgos, Spain.
Croatian: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero Burgos, Španjolska.
English: Number of Baseline Mutations1
Croatian: Broj početnih mutacija 1
English: • irritated or runny nose
Croatian: • iritacija nosa ili curenje iz nosa
English: It is not known whether abacavir can be removed by peritoneal dialysis or haemodialysis.
Croatian: Nije poznato može li se abakavir izlučiti peritonealnom dijalizom ili hemodijalizom.
English: 1 Major IAS-USA (Dec 2009) defined mutations for Abacavir or Lamivudine
Croatian: 1 Glavne IAS-USA (Prosinac 2009) mutacije na abakavir ili lamivudin
English: Very rare: Cases of peripheral neuropathy (or paraesthesia) have been reported
Croatian: Vrlo rijetko: zabilježeni su slučajevi periferne neuropatije
English: Abacavir and lamivudine triphosphates show significantly less affinity for host cell DNA polymerases.
Croatian: Trifosfati abakavira i lamivudina pokazuju značajno manji afinitet za DNK polimeraze stanice domaćina.
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to CART.
Croatian: Iako se smatra da postoji više uzroka (uključujući primjenu kortikosteroida, uživanje alkohola, tešku imunosupresiju, veći indeks tjelesne mase), zabilježeni su slučajevi osteonekroze, osobito u bolesnika s uznapredovalom HIV infekcijom i/ili onih koji su dugo vremena izloženi kombiniranom antiretrovirusnom liječenju.
English: The presence of M184V with K65R does give rise to crossresistance between abacavir, tenofovir, didanosine and lamivudine, and M184V with L74V gives rise to cross-resistance between abacavir, didanosine and lamivudine.
Croatian: Prisustvo M184V s K65R uzrokuje križnu rezistenciju između abakavira, tenofovira, didanozina i lamivudina, a prisustvo M184V s L74V uzrokuje križnu rezistenciju između abakavira, didanozina i lamivudina.
English: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero Burgos, Spain
Croatian: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero Burgos, Španjolska
English: The EU RMP of the abacavir (ABC) containing products (Ziagen, Kivexa and Trizivir) includes the following risk minimisation plan in relation to abacavir hypersensitivitiy reaction (HSR), which is an important identified risk:
Croatian: EU RMP za lijekove koji sadrže abakavir (ABC) (Ziagen, Kivexa i Trizivir) uključuje sljedeći plan minimalizacije rizika vezano uz abakavir i reakcije preosjetljivosti (HSR)
English: Following multiple oral doses of abacavir 300 mg twice a day there is no significant accumulation of abacavir.
Croatian: Nakon višestrukih oralnih doza abakavira od 300 mg dva puta na dan nije bilo značajnog nakupljanja lijeka.
English: ABC Hypersensitivity (including risk of reduced clinical vigilance for ABC HSR following HLA-B*5701 screening).
Croatian: Sigurnosni problem ABC preosjetljivost (uključujući rizik smanjene kliničke vigilancije za ABC HSR nakon HLA-B*5701 probira).
English: Intravenous studies with abacavir and lamivudine showed that the mean apparent volume of distribution is 0.8 and 1.3 l/kg respectively.
Croatian: Intravenska ispitivanja s abakavirom i lamivudinom pokazale su da prividni volumen distribucije iznosi oko 0,8 l/kg odnosno 1,3 l/kg.
English: In long-term oral carcinogenicity studies in rats and mice, lamivudine did not show any carcinogenic potential.
Croatian: U ispitivanjima kancerogenosti pri dugotrajnoj primjeni oralnih doza u štakora i miševa, lamivudin nije pokazao nikakav kancerogeni potencijal.
English: Kivexa should not be taken with any other medicinal products containing lamivudine (see section 4.4).
Croatian: Kivexa se ne smije uzimati niti s jednim drugim lijekom koji sadrži lamivudin (vidjeti dio 4.4).
English: Kivexa is used to treat HIV (human immunodeficiency virus) infection in adults, adolescents and in children weighing at least 25 kg.
Croatian: Kivexa je namijenjena liječenju infekcije HIV-om (virusom humane imunodeficijencije) u odraslih, adolescenata i djece tjelesne težine od najmanje 25 kg.
English: No clinical data are available in patients with moderate or severe hepatic impairment, therefore the use of Kivexa is not recommended unless judged necessary.
Croatian: Nema kliničkih podataka za bolesnike s umjerenim ili teškim oštećenjem jetre, stoga se ne preporučuje primjena lijeka Kivexa osim ako se procijeni da je neophodna.
English: Very rarely cases of erythema multiforme, Stevens-Johnson syndrome or toxic epidermal necrolysis have been reported where abacavir hypersensitivity could not be ruled out.
Croatian: Vrlo su rijetko prijavljeni slučajevi multiformnog eritema, Stevens-Johnsonova sindroma ili toksične epidermalne nekrolize kod kojih se nije mogla isključiti preosjetljivost na abakavir.
English: Nucleoside and nucleotide analogues have been demonstrated in vitro and in vivo to cause a variable degree of mitochondrial damage.
Croatian: Nukleozidni i nukleotidni analozi su do sada pokazali u in vitro i in vivo studijama da uzrokuju promjenjiv stupanj oštećenja mitohondrija.
English: Hypersensitivity reactions can start at any time during treatment with Kivexa, but are more likely during the first 6 weeks of treatment.
Croatian: Reakcije preosjetljivosti mogu započeti u bilo koje vrijeme terapije lijekom Kivexa, no najčešće tijekom prvih 6 tjedana liječenja.
English: Abacavir + lamivudine + NNRTI
Croatian: Abakavir + lamivudin + NNRTI
English: However, paediatric pharmacokinetic studies with tablet formulations have demonstrated that once daily dosing provides equivalent AUC24 to twice daily dosing of the same total daily dose.
Croatian: Međutim, ispitivanja pedijatrijske farmakokinetike s formulacijom tablete pokazala su da doziranje jedanput na dan daje AUC24 ekvivalentan doziranju dvaput na dan za istu sveukupnu dnevnu dozu.
English: The true extent of CNS penetration of lamivudine and its relationship with any clinical efficacy is unknown.
Croatian: Stvarni opseg prodiranja lamivudina u središnji živčani sustav i povezanost s kliničkom djelotvornošću nije poznat.
English: These hypersensitivity reactions have been seen more frequently in people taking medicines that contain abacavir.
Croatian: Te su reakcije preosjetljivosti primijećene češće u osoba liječenih lijekovima koji sadrže abakavir.
English: Common: Rash, alopecia Rare: Angioedema
Croatian: Često: osip, alopecija Rijetko: angioedem
English: This potential difference is sufficiently small to draw an overall conclusion of non-inferiority of abacavir once daily over abacavir twice daily.
Croatian: Ta potencijalna razlika je dovoljno mala da se može donijeti konačan zaključak kako je doziranje abakavira jednom na dan jednakovrijedno doziranju dvaput na dan.
English: Consider more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided.
Croatian: Razmotrite češće praćenje virusnog opterećenja HIV-1 u slučaju kada se dugotrajna istodobna primjena ne može izbjeći.
English: The other ingredients are microcrystalline cellulose, sodium starch glycollate and magnesium stearate in the core of the tablet.
Croatian: Drugi sastojci su mikrokristalična celuloza, natrijev škroboglikolat i magnezijev stearat u jezgri tablete.
English: >1 log reduction in HIV RNA or <50 cp/mL
Croatian: >1 log smanjenje HIV RNA ili <50 cp/mL
English: In patients with mild hepatic impairment (Child-Pugh score 5-6) close monitoring is required, including monitoring of abacavir plasma levels if feasible (see sections 4.4 and 5.2).
Croatian: Bolesnike s blagim oštećenjem jetre koji koriste abakavir (Child-Pugh vrijednosti 5-6 ) potrebno je pažljivo pratiti, uključujući praćenje razine abakavira u plazmi, ako je moguće (vidjeti dijelove 4.4 i 5.2).
English: • high doses of trimethoprim/sulfamethoxazole, an antibiotic
Croatian: • visoke doze trimetoprima/sulfametoksazola, antibiotika.
English: Lamivudine-TP and carbovir-TP (the active triphosphate form of abacavir) are substrates for and competitive inhibitors of HIV reverse transcriptase (RT).
Croatian: Lamivudin-TP i karbovir-TP (aktivni trifosfatni oblik abakavira) su supstrati i kompetitivni inhibitori HIV reverzne transkriptaze (RT).
English: No definitive recommendation on dose reduction is possible in patients with mild hepatic impairment due to substantial variability of abacavir exposure.
Croatian: Ne može se dati konačna preporuka za redukciju doze u bolesnika s blagim oštećenjem jetre zbog znatnih varijacija u izloženosti abakaviru.
English: Interaction not studied.
Croatian: Nema studije interakcije.
English: When concomitant administration with co-trimoxazole is warranted, patients should be monitored clinically.
Croatian: Kada je neizbježna istodobna terapija s kotrimoksazolom bolesnik bi se morao klinički nadzirati.