FrancophonIA/ELRC3.0 huggingface dataset:
English: The results showed that there was a mean (90%CI) increase of 1.89 fold [1.32; 2.70] in the abacavir AUC, and 1.58 [1.22; 2.04] fold in the elimination half-life.
Danish: Resultaterne viste, at AUC for abacavir i gennemsnit (90 % CI) steg 1,89 gange (1,32 - 2,70), og abacavirs halveringstid steg 1,58 gange (1,222,04).
English: Major symptoms associated with ABC HSR are fever (~80%), rash (~70%), gastrointestinal symptoms (>50%) such as nausea, abdominal pain, vomiting, and diarrhoea, generalise malaise, fatigue, and headache (~50%) and other symptoms (~30%) such as respiratory, mucosal, and musculoskeletal symptoms.
Danish: (~70 %), gastrointestinale symptomer (> 50 %) som f.eks. kvalme, abdominalsmerter, opkastning og diarré, generel utilpashed, træthed, og hovedpine (~50 %) og andre symptomer (~30 %) som f.eks. respiratoriske, slimhinde-, og muskuloskeletale symptomer.
English: The demonstration of the benefit of Ziagen is mainly based on results of studies performed with a twice daily regimen, in treatment-naïve adult patients on combination therapy (see section 5.1).
Danish: Fordelen ved Ziagen er hovedsageligt påvist i studier med et 2 gange daglig regime hos behandlingsnaive voksne patienter i kombinationsbehandling (se pkt.
English: Methyl parahydroxybenzoate (E218) 1.5 mg/ml Propyl parahydroxybenzoate (E216) 0.18 mg/ml For the full list of excipients see section 6.1.
Danish: Methylparahydroxybenzoat (E218) 1,5 mg/ml Propylparahydroxybenzoat (E216) 0,18 mg/ml Alle hjælpestoffer er anført under pkt.
English: In adults moderately exposed to antiretroviral therapy the addition of abacavir to combination antiretroviral therapy provided modest benefits in reducing viral load (median change 0.44 log10 copies/ml at 16 weeks).
Danish: Hos voksne som tidligere havde modtaget begrænset antiretroviral behandling, havde tillæg af abacavir til kombineret antiretroviral behandling begrænset værdi i reduktion af virusbyrden (median for ændring 0,44 log10 kopier/ml efter 16 uger).
English: At therapeutic dosages a dosage of 300 mg twice daily, the mean (CV) steady state Cmax and Cmin of abacavir are approximately 3.00 µg/ml (30%) and 0.01 µg/ml(99%), respectively.
Danish: Ved terapeutiske doser, en dosis på 300 mg 2 gange daglig, er den gennemsnitlige (CV) steady state Cmax og Cmin for abacavir cirka 3,00 µg/ml (30 %) henholdsvis 0,01 µg/ml (99 %).
English: In the intent-to-treat (ITT) population, 70% of patients in the abacavir group, compared to 69% of patients in the zidovudine group, achieved a virologic response of plasma HIV-1 RNA ≤50 copies/ml by Week 48 (point estimate for treatment difference: 0.8, 95% CI -6.3, 7.9).
Danish: I ”intent-to-treat” (ITT) populationen, opnåede 70 % af patienterne i abacavirgruppen, sammenlignet med 69 % af patienterne i zidovudingruppen, et virologisk respons af plasma hiv-1-RNA ≤ 50 kopier/ml ved uge 48 (punktestimat for behandlingsforskel: 0,8, 95 % CI -6,3 - 7,9).
English: Ziagen 300 mg film-coated tablets Abacavir
Danish: Ziagen 300 mg filmovertrukne tabletter Abacavir
English: Medicinal product subject to restricted medical prescription (See Annex I Summary of Product Characteristics, 4.2).
Danish: Lægemidlet må kun udleveres efter ordination på en recept udstedt af en begrænset lægegruppe (se bilag I: Produktresumé; pkt.
English: In controlled clinical studies laboratory abnormalities related to Ziagen treatment were uncommon, with no differences in incidence observed between Ziagen treated patients and the control arms.
Danish: I kontrollerede kliniske studier var afvigende laboratoriefund, som havde sammenhæng med behandlingen med Ziagen, usædvanlige.
English: After a 600 mg abacavir tablet dose, the mean (CV) abacavir Cmax was approximately 4.26 µg/ml (28%) and the mean (CV) AUC∞ was 11.95 µg.h/ml (21%).
Danish: Efter dosering af 600 mg abacavir som tablet var den gennemsnitlige (CV) abacavir Cmax ca. 4,26 µg/ml (28 %) og den gennemsnitlige (CV) AUC∞ var 11,95 µg·time/ml (21 %).
English: General disorders and administration site conditions Common: fever, lethargy, fatigue
Danish: Almene symptomer og reaktioner på administrationsstedet Almindelig: Feber, svær udmatning, træthed
English: Ziagen 20 mg/ml oral solution Abacavir
Danish: Ziagen 20 mg/ml oral opløsning Abacavir
English: Abacavir 8 mg/kg TwiceDaily Dosing Geometric Mean (95% Cl)
Danish: Abacavir 8 mg/kg 2 gange daglig Geometrisk gennemsnit (95 % CI)
English: Children weighing 14 to < 20 kg: The recommended dose is 300 mg daily.
Danish: Børn, der vejer 14 til < 20 kg: Den anbefalede dosis er 300 mg daglig.
English: Clinically significant reduction of susceptibility to abacavir has been demonstrated in clinical isolates of patients with uncontrolled viral replication, who have been pre-treated with and are resistant to other nucleoside inhibitors.
Danish: In vivo-resistens (tidligere behandlede patienter): Der er påvist klinisk signifikant reduktion af følsomhed over for abacavir i kliniske isolater fra patienter med ukontrolleret virusreplikation, som tidligere er behandlet med, og nu er resistente over for, andre nukleosidinhibitorer.
English: The Ziagen pack includes an Alert Card, to remind you and medical staff about hypersensitivity reactions.
Danish: Der er vedlagt et oplysningskort i pakningen med Ziagen for at gøre dig og sundhedspersonalet opmærksom på overfølsomhedsreaktioner over for abacavir.
English: Results indicate that the FDC group was non-inferior to the abacavir twice daily group, based on similar reductions in HIV-1 RNA as measured by average area under the curve minus baseline (AAUCMB, -1.65 log10 copies/ml versus -1.83 log10 copies/ml respectively, 95% CI -0.13, 0.38).
Danish: Resultater indikerer, at FDC-gruppen var ikke-inferiør over for gruppen med abacavir 2 gange daglig baseret på ensartede reduktioner i hiv-1-RNA målt som det gennemsnitlige areal under kurven minus baseline (AAUCMB, henholdsvis -1,65 log10 kopier/ml versus1,83 log10 kopier/ml, 95 % CI -0,13 - 0,38).
English: Delay in stopping treatment with Ziagen after the onset of hypersensitivity may result in a life-threatening reaction.
Danish: Forsinkelse i seponering af Ziagen efter indtrædelse af en overfølsomhedsreaktion kan resultere i en livstruende situation.
English: One randomised, double blind, placebo controlled clinical study in adults has compared the combination of abacavir, lamivudine and zidovudine to the combination of indinavir, lamivudine and zidovudine.
Danish: Kombinationen af abacavir, lamivudin og zidovudin er i ét randomiseret, dobbeltblindet, placebokontrolleret klinisk studie hos voksne sammenlignet med kombinationen af indinavir, lamivudin og zidovudin.
English: Sorbitol (E420) 340 mg/ml
Danish: Hjælpestoffer, som behandleren skal være opmærksom på: Sorbitol (E420) 340 mg/ml
English: The inclusion of zidovudine in the regimen has been found to reduce the frequency of L74V and K65R selection in the presence of abacavir (with zidovudine: 0/40, without zidovudine: 15/192, 8%).
Danish: Når zidovudin inkluderes i behandlingen med abacavir, reduceres forekomsten af L74V- og K65R-mutationerne (med zidovudin: 0/40, uden zidovudin: 15/192, 8 %).
English: L74V Y115F M184V/I TAMs3
Danish: M184V/I TAM'er3
English: Children weighing ≥ 20 kg to < 25 kg: The recommended dose is 450 mg daily.
Danish: Børn, der vejer >20 til <25 kg: Den anbefalede dosis er 450 mg daglig.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse reactions.
Danish: Patienter co-inficeret med kronisk hepatitis B eller C Patienter med kronisk hepatitis B eller C, behandlet med antiretroviral kombinationsbehandling, har større risiko for alvorlige og potentielt letale leverbivirkninger.
English: How to measure the dose and take the medicine
Danish: Afmåling og indtagelse af dosis
English: Patients changing from the twice daily dosing regimen to the once daily dosing regimen should take the recomended once daily dose (as described above) approximately 12 hours after the last twice daily dose, and then continue to take the recomended once daily dose (as described above) approximately every 24 hours.
Danish: Patienter, som skifter fra at tage 2 daglige doser til at tage én daglig dosis, skal tage den anbefalede ene daglige dosis (som beskrevet ovenfor) ca. 12 timer efter den seneste af de 2 daglige doser.
English: Before initiating treatment with abacavir, screening for carriage of the HLA-B*5701 allele should be performed in any HIV-infected patient, irrespective of racial origin(see section 4.4).
Danish: Før initiering af behandling med abacavir skal alle hiv-patienter, uanset raceoprindelse, screenes for eventuelt at være bærer af HLA-B*5701-allel (se pkt 4.4).
English: Children from one year of age weighing less than 25 kg
Danish: Børn fra 1 år, der vejer mindre end 25 kg:
English: SN: NN
Danish: NN:
English: This can be taken either as one 300 mg tablet twice a day or two 300 mg tablets once a day.
Danish: Denne kan tages enten som en 300 mg tablet 2 gange daglig eller som to 300 mg tabletter én gang daglig.
English: In a multicentre, double-blind, controlled study (CNA30024), 654 HIV-infected, antiretroviral therapy-naïve patients were randomised to receive either abacavir 300 mg twice daily or zidovudine 300 mg twice daily, both in combination with lamivudine 150 mg twice daily and efavirenz 600 mg once daily.
Danish: I et multicenter, dobbeltblindet, kontrolleret studie (CNA30024), blev 654 hiv-inficerede, antiretroviral behandlingsnaive patienter randomiseret til at modtage enten abacavir 300 mg 2 gange daglig eller zidovudin 300 mg 2 gange daglig, begge i kombination med lamivudin 150 mg 2 gange daglig og efavirenz 600 mg én gang daglig.
English: These findings should be considered for any child exposed in utero to nucleotide and nucleotide analogues, who presents with severe clinical findings of unknown etiology, particularly neurologic findings.
Danish: Mitokondriel dysfunktion bør overvejes hos alle børn med svære kliniske symptomer af ukendt ætiologi, især neurologiske symptomer, der har været eksponeret for nukleosid-/nukleotid-analoger in utero.
English: Ziagen 300 mg tablets.
Danish: Ziagen 300 mg filmovertrukne tabletter.
English: • Children weighing at least 14 kg and less than 20 kg: The usual dose of Ziagen is 300 mg a day.
Danish: • Børn, der vejer mindst 14 kg og mindre end 20 kg: Den sædvanlige dosis er 300 mg daglig.
English: 60 film-coated, scored tablets
Danish: 60 filmovertrukne tabletter med delekærv
English: ABC HSR and expand on the information already included in the currently approved EU SPC:
Danish: Hovedelementer i uddannelsesmaterialet for at øge forståelsen for og opmærksomheden på ABCoverfølsomhedsreaktion og udvide informationen, som allerede er inkluderet i det nuværende godkendte EU produktresumé:
English: Keep this leaflet.
Danish: Tag hætten af.
English: The oral solution is clear to slightly opalescent yellowish, aqueous solution which may turn into a brown colour over time
Danish: Den orale opløsning er en klar til svagt opaliserende gullig, vandig opløsning, der kan blive brunlig over tid.
English: 1 if you get a skin rash, OR
Danish: 1) du får udslæt ELLER
English: Talk to your doctor before you start taking it again.
Danish: Tal med lægen, inden du begynder at tage Ziagen igen.
English: Placental transfer of abacavir and/or its related metabolites has been shown to occur in human.
Danish: Det er vist, at abacavir og/eller metabolitter heraf passerer placenta hos mennesker.
English: How to take Ziagen
Danish: Sådan skal du tage Ziagen
English: In vitro studies have demonstrated that its mechanism of action in relation to HIV is inhibition of the HIV reverse transcriptase enzyme, an event which results in chain termination and interruption of the viral replication cycle.
Danish: In vitro studier har vist, at virkningsmekanismen over for hiv er en hæmning af hiv-revers transkriptaseenzymet.
English: Children from 3 months of age weighing less than 25 kg
Danish: Børn fra 3 månder, der vejer mindre end 25 kg:
English: Abacavir 16 mg/kg OnceDaily Dosing Geometric Mean (95% Cl)
Danish: Abacavir 16 mg/kg én gang daglig Geometrisk gennemsnit (95 % CI)
English: Other medicines and Ziagen Tell your doctor or pharmacist if you are taking any other medicines, or if you have taken any recently, including herbal medicines or other medicines you bought without a prescription.
Danish: Brug af anden medicin sammen med Ziagen Fortæl altid lægen eller apotekspersonalet, hvis du bruger anden medicin eller har gjort det for nylig.
English: • Children weighing at least 20 kg and less than 25 kg: The usual dose of Ziagen is 450 mg a day.
Danish: • Børn, der vejer mindst 20 kg og mindre end 25 kg: Den sædvanlige dosis er 450 mg daglig.
English: Insert the syringe firmly into the adapter
Danish: Sæt sprøjten godt fast i tilpasningsstykket.
English: Carefully read all the information about hypersensitivity reactions in Section 4.
Danish: Læs grundigt alle oplysningerne om overfølsomhedsreaktioner under punkt 4.
English: if you are allergic (hypersensitive) to abacavir (or any other medicine containing abacavir -such as Trizivir, Triumeq or Kivexa) or any of the other ingredients of this medicine (listed in Section
Danish: • hvis du er allergisk (overfølsom) over for abacavir (eller anden medicin, der indeholder abacavir, f.eks. Trizivir, Triumeq eller Kivexa) eller et af de øvrige indholdsstoffer i dette lægemiddel (angivet i punkt 6).
English: • Ziagen must be stopped without delay, even in the absence of the HLA-B*5701 allele, if an HSR is suspected.
Danish: Ziagen skal seponeres uden forsinkelse, selv hos patienter uden HLA-B*5107-allel, hvis der opstår mistanke om en overfølsomhedsreaktion.
English: In study ESS30008, 260 patients with virologic suppression on a first line therapy regimen containing abacavir 300 mg plus lamivudine 150 mg, both given twice daily and a PI or NNRTI, were randomised to continue this regimen or switch to abacavir/lamivudine FDC plus a PI or NNRTI for 48 weeks.
Danish: I studiet ESS30008 blev 260 patienter med virologisk suppression på et ”first line” behandlingsregime bestående af abacavir 300 mg plus lamivudin 150 mg begge givet 2 gange daglig og en PI eller NNRTI, randomiseret til at fortsætte dette regime eller at skifte til abacavir/lamivudin FDC plus en PI eller NNRTI i 48 uger.
English: The recommended dose of Ziagen is 600 mg daily (30 ml).
Danish: Den anbefalede dosis Ziagen er 600 mg daglig (30 ml).
English: Methyl parahydroxybenzoate (E218) Propyl parahydroxybenzoate (E216) Propylene glycol (E1520)
Danish: Vandfri citronsyre Methylparahydroxybenzoat (E218) Propylparahydroxybenzoat (E216) Propylenglycol (E1520) Maltodextrin
English: The other ingredients are microcrystalline cellulose, sodium starch glycollate, magnesium stearate and colloidal anhydrous silica in the core of the tablet.
Danish: Øvrige indholdsstoffer: Tabletkerne: Mikrokrystallinsk cellulose, natriumstivelsesglycolat, magnesiumstearat og kolloid vandfri silica.
English: The overall selection frequency for M184V or M184I was high (54%), and less common was the selection of L74V (5%), K65R (1%) and Y115F (1%).
Danish: Mindre almindelige var mutationerne L74V (5 %), K65R (1 %) og Y115F (1 %).
English: take Ziagen, or any other medicine containing abacavir (e.g. Trizivir, Triumeq or Kivexa).
Danish: tage Ziagen eller anden medicin, der indeholder abacavir (f.eks. Trizivir, Triumeq eller Kivexa).
English: The abacavir + lamivudine once daily dosing group was demonstrated to be non-inferior to the twice daily group according to the pre-specified non-inferiority margin of -12%, for the primary endpoint of <80 c/ml at Week 48 as well as at Week 96 (secondary endpoint) and all other thresholds tested (<200c/ml, <400c/ml, <1000c/ml), which all fell well within this non-inferiority margin.
Danish: Abacavir + lamivudin-gruppen, som fik én daglig dosis, blev vist at være non-inferior til gruppen med 2 daglige doser ifølge den præspecificerede non-inferioritetsmargin på -12 % ved det primære endepunkt, som var <80 kopier/ml ved uge 48, og ligeledes ved uge 96 (sekundært endepunkt) samt alle andre grænser testet (< 200 kopier/ml, < 400 kopier/ml, < 1.000 kopier/ml), som alle var indenfor denne non-inferioritetsmargin.
English: K65R
Danish: Antal genotyper i behandling K65R
English: The usual dose of Ziagen is 600 mg a day.
Danish: Den sædvanlige dosis af Ziagen er 600 mg daglig.
English: 1206 paediatric patients aged 3 months to 17 years enrolled in the ARROW Trial
Danish: 1.206 pædiatriske patienter i alderen 3
English: In heavily NRTI pretreated patients the efficacy of abacavir is very low.
Danish: Hos patienter som forud har modtaget massiv behandling med nukleosid revers transkriptasehæmmere, NTRI, er effekten af abacavir meget lille.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON - ORAL SOLUTION
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE FLASKEETIKET - ORAL OPLØSNING
English: Other common symptoms are: • nausea (feeling sick), vomiting (being sick), diarrhoea, abdominal (stomach) pain, severe tiredness
Danish: Andre almindelige symptomer: • kvalme, opkastning, diarré, mavesmerter, udtalt træthed.
English: • Ziagen should never be initiated in patients with a positive HLA-B*5701 status, nor in patients with a negative HLA-B*5701 status who had a suspected abacavir HSR on a previous abacavir-containing regimen.
Danish: Ziagen bør aldrig anvendes til patienter med positiv HLA-B*5701-status, ej heller til patienter med negativ HLA-B*5701-status med tidligere mistanke om en overfølsomhedsreaktion over for et behandlingsregime indeholdende abacavir (f.eks. Kivexa, Trizivir, Triumeq).
English: In study CAL30001, 182 treatment-experienced patients with virologic failure were randomised and received treatment with either the fixed-dose combination of abacavir/lamivudine (FDC) once daily or abacavir 300 mg twice daily plus lamivudine 300 mg once daily, both in combination with tenofovir and a PI or an NNRTI for 48 weeks.
Danish: I studiet CAL30001 blev 182 tidligere behandlede patienter med virologisk svigt randomiseret og de modtag enten fastdosiskombinationen (FDC) af abacavir/lamivudin én gang daglig, eller abacavir 300 mg 2 gange daglig plus lamivudin 300 mg én gang daglig, begge i kombination med tenofovir og en PI eller en NNRTI i 48 uger.
English: Children receiving abacavir oral solution according to the recommended dosage regimen achieve plasma abacavir exposure similar to adults.
Danish: Børn, som får abacavir oral opløsning i henhold til den doseringsanbefalingerne, opnår abacavir-plasmaniveauer indenfor det interval, der er observeret hos voksne.
English: Although a similar antiviral effect was observed between the abacavir and indinavir containing regimens in terms of proportion of patients with undetectable viral load (≤400 copies/ml; intention to treat analysis (ITT), 47% versus 49%; as treated analysis (AT), 86% versus 94% for abacavir and indinavir combinations respectively), results favoured the indinavir combination, particularly in the subset of patients with high viral load (>100,000 copies/ml at baseline; ITT, 46% versus 55%; AT, 84% versus 93% for abacavir and indinavir respectively).
Danish: analyse af behandlede (AB) på 86 % versus 94 % for kombinationerne med henholdsvis abacavir og indinavir), var resultaterne til fordel for kombinationen med indinavir, særligt hos undergruppen af patienter med høj virusbyrde (udgangsværdi > 100.000 kopier/ml; ITT på 46 % versus 55 %; AB på 84 % versus 93 % for henholdsvis abacavir og indinavir).
English: There have been reports of mitochondrial dysfunction in HIVnegative infants exposed in utero and/or post-natally to nucleoside analogues (see section 4.4).
Danish: Der er rapporteret mitokondriel dysfunktion hos hiv-negative nyfødte, der in utero eller efter fødslen har været eksponeret for nukleosidanaloger se pkt.
English: Description of Selected Adverse Reactions
Danish: Beskrivelse af udvalgte bivirkninger
English: - fever - shortness of breath, sore throat or cough - nausea or vomiting, diarrhoea or abdominal pain - severe tiredness or achiness, or generally feeling ill
Danish: - feber - åndenød, ondt i halsen eller hoste - kvalme, opkastning, diarré eller mavesmerter - udtalt træthed, smerter eller en generel følelse af at være syg.
English: Appropriate use of abacavir can be guided using currently recommended resistance algorithms.
Danish: Gældende resistensalgoritmer kan vejlede om hensigtsmæssig brug af abacavir.
English: None M184V alone Any one NRTI mutation 82 Any two NRTI-associated mutations Any three NRTI-associated mutations Four or more NRTIassociated mutations
Danish: En NRTI-mutation 82 To NRTI-forbundne mutationer
English: Ziagen 20 mg/ml oral solution
Danish: Ziagen 20 mg/ml oral opløsning
English: Sorbitol 70% (E420)
Danish: Sorbitol 70 % (E420) Saccharinnatrium Natriumcitrat
English: If you have any further questions ask your doctor or pharmacist.
Danish: Er du i tvivl, så spørg lægen eller apotekspersonalet.
English: The recommended dose of Ziagen is 600 mg daily.
Danish: Den anbefalede dosis Ziagen er 600 mg daglig.
English: If you cannot swallow the tablet(s), you may crush and combine them with a small amount of food or drink, and take all the dose immediately.
Danish: Hvis du ikke kan synke hele tabletter, kan du knuse dem og blande dem i lidt mad eller væske og derefter straks tage hele dosis.
English: Abacavir penetrates the cerebrospinal fluid (CSF) (see section 5.2), and has been shown to reduce HIV-1 RNA levels in the CSF.
Danish: 5.2) og nedsætter påviseligt mængden af hiv1-RNA i CSF.
English: Each film-coated tablet contains 300 mg abacavir (as sulfate).
Danish: Hver filmovertrukken tablet indeholder 300 mg abacavir (som sulfat).
English: You should have been tested for this gene before Ziagen was prescribed for you.
Danish: Du skal derfor undersøges for, om du har dette gen, inden lægen ordinerer Ziagen.
English: Results indicate that the FDC group was associated with a similar virologic outcome (non-inferior) compared to the abacavir plus lamivudine group, based on proportions of subjects with HIV-1 RNA < 50 copies/ml (90% and 85% respectively, 95% CI -2.7, 13.5).
Danish: Resultaterne indikerer, at FDC-gruppen kunne associeres med et ensartet virologisk udfald (ikke-inferiørt) sammenlignet med abacavir plus lamivudingruppen baseret på forholdet mellem individer med hiv-1 RNA < 50 kopier/ml (henholdsvis 90 % og 85 %, 95 % CI -2,7 - 13,5).
English: Based on the results of in vitro experiments and the known major metabolic pathways of abacavir, the potential for P450 mediated interactions with other medicinal products involving abacavir is low.
Danish: Muligheden for P450-medierede interaktioner med andre lægemidler, som involverer abacavir, er lille baseret på resultater af in vitro forsøg og de kendte betydende metaboliseringsveje for abacavir.
English: Diagnosis of Abacavir Hypersensitivity Reaction
Danish: Klinisk beskrivelse af overfølsomhedsreaktion over for abacavir
English: - fever - shortness of breath, sore throat or cough - nausea or vomiting or diarrhoea or abdominal pain - severe tiredness or achiness or generally feeling ill If you have discontinued Ziagen due to this reaction, YOU MUST NEVER TAKE Ziagen or any other abacavir containing medicine (e.g. Kivexa, Trizivir or Triumeq) again, as within hours you may experience a life-threatening lowering of your blood pressure or death.
Danish: Hvis du er stoppet med at tage Ziagen på grund af denne reaktion, MÅ DU ALDRIG TAGE Ziagen eller andre lægemidler indeholdende abacavir (f.eks. Kivexa, Trizivir eller Triumeq) igen, da du inden for timer kan risikere et livstruende fald i blodtrykket eller at dø.