FrancophonIA/ELRC3.0 huggingface dataset:
English: Yellow, oval-shaped, tablet of dimensions 21.59 mm x 11.30 mm, debossed with the corporate logo and 776 on one side and plain on the other side.
Croatian: Žuta, ovalna tableta dimenzija 21,59 mm x 11,30 mm, s utisnutim logotipom proizvođača i oznakom „776“ na jednoj strani i bez oznake na drugoj strani.
English: The principal mode of action of 3TC-TP is inhibition of RT via DNA chain termination after incorporation of the nucleotide analogue.
Croatian: Osnovni mehanizam djelovanja metabolita 3TC-TP je inhibicija reverzne transkriptaze prekidanjem lanca DNK nakon ugradnje nukleotidnog analoga.
English: At the highest dosage levels, minor effects on indicators of liver and kidney function were seen together with occasional reductions in liver weight.
Croatian: Pri najvišim primijenjenim dozama opaženi su manji učinci na pokazatelje funkcije jetre i bubrega, uz povremena smanjenja mase jetre.
English: • rifabutin (a medicine to treat some bacterial infections such as tuberculosis)
Croatian: • rifabutin (lijek za liječenje nekih bakterijskih infekcija, kao što je tuberkuloza)
English: Co-administration is contraindicated.
Croatian: Istodobna je primjena kontraindicirana.
English: Approximately 70-80 % of the intravenous dose of tenofovir is recovered as unchanged medicinal product in the urine within 72 hours of dosing.
Croatian: Približno 70 - 80% intravenski primijenjene doze tenofovira pronalazi se u obliku nepromijenjena lijeka u mokraći unutar 72 sata od primjene.
English: There is not sufficient clinical evidence to support the use of doravirine in patients infected with HIV-1 with evidence of resistance to the NNRTI class.
Croatian: Nema dovoljno kliničkih dokaza koji bi podržali primjenu doravirina u bolesnika zaraženih HIV-1, a u kojih je dokazana rezistencija na NNRTI-je.
English: Tenofovir is excreted in human milk.
Croatian: Tenofovir se izlučuje u majčino mlijeko.
English: One subject developed RT M184M/I mutation and phenotypic resistance to 3TC and FTC during treatment with their baseline regimen.
Croatian: Jedan je ispitanik razvio mutaciju M184M/I u reverznoj transkriptazi i fenotipsku rezistenciju na 3TC i FTC tijekom liječenja početnim režimom.
English: Refer to Resistance section for NNRTI substitutions that were part of exclusion criteria.
Croatian: Vidjeti odlomak „Rezistencija“ za supstitucije povezane s rezistencijom na NNRTI-je koje su bile dio isključnih kriterija.
English: There are limited data available on the use of doravirine, lamivudine, and tenofovir disoproxil in patients aged 65 years and over.
Croatian: Dostupni su ograničeni podaci o primjeni doravirina, lamivudina i tenofovirdizoproksila u bolesnika u dobi od 65 i više godina.
English: Animal studies do not indicate harmful effects of doravirine, lamivudine, or tenofovir disoproxil on fertility at exposure levels higher than the exposure in humans at the recommended clinical dose (see section 5.3).
Croatian: Ispitivanja na životinjama ne ukazuju na štetne učinke doravirina, lamivudina ili tenofovirdizoproksila na plodnost pri razinama izloženosti višima od onih koje se postižu u ljudi kod primjene preporučene kliničke doze (vidjeti dio 5.3).
English: Limited data are available for patients whose virus expressed a Y115F substitution (n = 3), Q151M substitution (n = 2), or T69 insertion (n = 4) in HIV-1 RT, all of whom had a reduced response in clinical trials.
Croatian: Dostupni su ograničeni podaci za bolesnike čiji je virus eksprimirao supstituciju Y115F (n=3), supstituciju Q151M (n=2) ili inserciju T69 (n=4) u reverznoj transkriptazi HIV-1, koji su svi imali smanjen odgovor u kliničkim ispitivanjima.
English: Administration of lamivudine in animal toxicity studies at high doses was not associated with any major organ toxicity.
Croatian: Primjena visokih doza lamivudina u ispitivanjima toksičnosti na životinjama nije bila povezana s toksičnošću nijednog važnog organa.
English: Lamivudine has been identified in breast-fed newborns/infants of treated women.
Croatian: Lamivudin je pronađen u dojenčadi liječenih žena.
English: Doravirine was excreted into the milk of lactating rats following oral administration, with milk concentrations approximately 1.5 times that of maternal plasma concentrations.
Croatian: Doravirin se nakon peroralne primjene izlučivao u mlijeko ženki štakora u laktaciji, a koncentracije u mlijeku bile su približno 1,5 puta veće od koncentracija u plazmi skotne ženke.
English: If Delstrigo is co-administered with rifabutin, the doravirine dose should be increased to 100 mg twice daily.
Croatian: Ako se Delstrigo primjenjuje istodobno s rifabutinom, potrebno je povećati dozu doravirina na 100 mg dvaput dnevno.
English: This may reduce your risk of early death or catching infections because your immune system is weak.
Croatian: Vaš imunološki sustav te tako smanjiti rizik od prijevremene smrti ili razvoja infekcija zbog oslabljenog imunološkog sustava.
English: DRV+r + NRTIs*
Croatian: DRV+r + NRTI-ji*
English: Reproduction studies with orally administered doravirine have been performed in rats and rabbits at exposures approximately 9 times (rats) and 8 times (rabbits) the exposure in humans at the recommended human dose (RHD) with no effects on embryo-foetal (rats and rabbits) or pre/postnatal (rats) development.
Croatian: Ispitivanja učinaka peroralno primijenjenog doravirina na reprodukciju provedena su na štakorima i kunićima pri razinama izloženosti približno 9 puta (štakori) i 8 puta (kunići) većima od onih koje se postižu u ljudi kod primjene preporučene doze za ljude, bez učinaka na embriofetalni razvoj (štakori i kunići) ili prenatalni/postnatalni razvoj (štakori).
English: Caution should be given to prescribing doravirine with medicinal products that may reduce the exposure of doravirine (see sections 4.3 and 4.5).
Croatian: Potreban je oprez pri propisivanju doravirina zajedno s lijekovima koji mogu smanjiti izloženost doravirinu (vidjeti dijelove 4.3 i 4.5).
English: Doravirine demonstrated antiviral activity against a broad panel of primary HIV-1 isolates (A, A1, AE, AG, B, BF, C, D, G, H) with EC50 values ranging from 1.2 nM to 10.0 nM.
Croatian: Doravirin je pokazao antivirusnu aktivnost protiv širokog panela primarnih izolata virusa HIV-1 (A, A1, AE, AG, B, BF, C, D, G, H), uz vrijednosti EC50 u rasponu od 1,2 nM do 10,0 nM.
English: • increased levels of creatinine in your blood
Croatian: • povišene razine kreatinina u krvi
English: • reducing the amount of HIV in your blood (this is called your ‘viral load')
Croatian: • smanjuje količinu HIV-a u krvi (što se naziva „virusnim opterećenjem“)
English: • muscle symptoms (pain, stiffness)
Croatian: • mišićni simptomi (bol, ukočenost)
English: Lamivudine Lamivudine did not affect male or female fertility in rats.
Croatian: Lamivudin Lamivudin nije utjecao na plodnost mužjaka ni ženki štakora.
English: Patients should be informed that fatigue, dizziness, and somnolence have been reported during treatment with Delstrigo (see section 4.8).
Croatian: Bolesnike je potrebno obavijestiti o tome da su tijekom liječenja lijekom Delstrigo prijavljeni umor, omaglica i somnolencija (vidjeti dio 4.8).
English: • aggression, hallucinations, difficulty adjusting to changes, mood changes, sleep walking
Croatian: • agresivnost, halucinacije, poteškoće s prilagođavanjem promjenama, promjene raspoloženja,
English: In the DRIVE-SHIFT clinical trial, no subjects developed genotypic or phenotypic resistance to DOR, 3TC, or TDF during the initial 48 weeks (immediate switch, N=447) or 24 weeks (delayed switch, N=209) of treatment with Delstrigo.
Croatian: U kliničkom ispitivanju DRIVE-SHIFT, nijedan ispitanik nije razvio genotipsku ili fenotipsku rezistenciju na DOR, 3TC ili TDF uz liječenje lijekom Delstrigo tijekom početnih 48 tjedana (prelazak bez odgode, N=447) ili tijekom 24 tjedna (odgođeni prelazak, N=209).
English: • carbamazepine, oxcarbazepine, phenobarbital, phenytoin
Croatian: • karbamazepin, okskarbazepin, fenobarbital, fenitoin
English: V106A (yielding a fold change of around 19) appeared as an initial substitution in subtype B virus, and V106A or M in subtype A and C virus.
Croatian: Mutacija V106A (koja je dovela do promjene od približno 19 puta u odnosu na početnu vrijednost) javila se kao početna supstitucija kod virusa podtipa B, a mutacija V106A ili M kod virusa podtipa
English: To monitor maternal-foetal outcomes in patients exposed to antiretroviral medicinal products while pregnant, an Antiretroviral Pregnancy Registry has been established.
Croatian: Registar trudnica liječenih antiretrovirusnim lijekovima Radi praćenja ishoda trudnoće za majku i fetus u bolesnica koje su tijekom trudnoće bile izložene antiretrovirusnim lijekovima, uspostavljen je Registar trudnica liječenih antiretrovirusnim lijekovima.
English: Although a limited number of subjects aged 65 years and over has been included (n = 36), no clinically relevant differences in the pharmacokinetics of doravirine have been identified in subjects at least 65 years of age compared to subjects less than 65 years of age in a Phase 1 trial or in a population pharmacokinetic analysis.
Croatian: Iako je u ispitivanje faze 1 i populacijsku farmakokinetičku analizu bio uključen ograničen broj ispitanika u dobi od 65 ili više godina (n=36), nisu utvrđene klinički značajne razlike u farmakokinetici doravirina u ispitanika u dobi od najmanje 65 godina u usporedbi s onima mlađima od 65 godina.
English: There was no clinically relevant difference in the pharmacokinetics of doravirine in a study comparing 8 subjects with moderate hepatic impairment (classified as Child-Pugh score B primarily due to increased encephalopathy and ascites scores) to 8 subjects without hepatic impairment.
Croatian: Nije bilo klinički značajne razlike u farmakokinetici doravirina u ispitivanju u kojem se 8 ispitanika s umjerenim oštećenjem funkcije jetre (svrstanih u kategoriju „Child-Pugh stadij B“ prvenstveno zbog povišenih rezultata za encefalopatiju i ascites) uspoređivalo s 8 ispitanika bez oštećenja funkcije jetre.
English: In a study comparing 8 subjects with severe renal impairment to 8 subjects without renal impairment, the single dose exposure of doravirine was 31 % higher in subjects with severe renal impairment.
Croatian: U ispitivanju u kojem se 8 ispitanika s teškim oštećenjem funkcije bubrega uspoređivalo s 8 ispitanika bez oštećenja funkcije bubrega izloženost doravirinu nakon primjene jednokratne doze bila je 31% veća u ispitanika s teškim oštećenjem funkcije bubrega.
English: After multiple-dose oral administration of lamivudine 300 mg once daily for 7 days to 60 healthy subjects, steady-state Cmax (Cmax,ss) was 2.04 ± 0.54 mcg per mL (mean ± SD) and the 24-hour steady-state AUC (AUC24,ss) was 8.87 ± 1.83 mcg•hour per mL.
Croatian: Nakon višestrukih doza lamivudina od 300 mg primijenjenih peroralno jedanput na dan tijekom 7 dana u 60 zdravih ispitanika, Cmax u stanju dinamičke ravnoteže (Cmax,ss) iznosio je 2,04 ± 0,54 μg/ml (srednja vrijednost ± standardno odstupanje ) dok je 24-satni AUC u stanju dinamičke ravnoteže (AUC24,ss) iznosio 8,87 ± 1,83 μg•h/ml.
English: Following oral administration, the terminal halflife of tenofovir is approximately 12 to 18 hours.
Croatian: Terminalni poluvijek tenofovira nakon peroralne primjene iznosi približno 12 - 18 sati.
English: Co-administration with other antiviral products
Croatian: Istodobna primjena s drugim antivirusnim lijekovima
English: Lamivudine Cmax decreased by 19 % with a high fat meal, while AUC was not significantly affected.
Croatian: Cmax lamivudina se uz obrok s visokim udjelom masnoća smanjio za 19%, dok se AUC nije značajno promijenio.
English: Bone abnormalities (infrequently contributing to fractures) may be associated with proximal renal tubulopathy.
Croatian: Abnormalnosti kostiju (koje rijetko pridonose prijelomima) mogu biti povezane s proksimalnom bubrežnom tubulopatijom.
English: Includes subjects who discontinued because of adverse event (AE) or death if this resulted in no virologic data on treatment during the specified window.
Croatian: Adverse event, AE) ili smrti, ako je ovakav ishod rezultirao nedostatkom viroloških podataka o liječenju u određenom vremenskom okviru.
English: Autoimmune disorders (such as Graves' disease, autoimmune hepatitis, polymyositis, and GuillainBarré syndrome) have also been reported to occur in the setting of immune reactivation; however, the time to onset is more variable and can occur many months after initiation of treatment.
Croatian: U uvjetima imunološke reaktivacije prijavljeni su i autoimuni poremećaji (kao što su Gravesova bolest, autoimuni hepatitis, polimiozitis i Guillain-Barréov sindrom); međutim, vrijeme do pojave je različito i ti se poremećaji mogu javiti više mjeseci nakon uvođenja liječenja.
English: The muscle pain, muscle weakness and decreases in potassium or phosphate in the blood may occur due to damage to kidney tubule cells.
Croatian: Bol u mišićima, mišićna slabost i snižene razine kalija ili fosfata u krvi mogu se javiti zbog oštećenja stanica bubrežnih kanalića.
English: What Delstrigo contains
Croatian: Što Delstrigo sadrži
English: • increased levels of creatine phosphokinase
Croatian: • povišene vrijednosti kreatin fosfokinaze
English: 3, 84 % were male, 27 % were non-white, 4 % had hepatitis B and/or C virus co-infection, 10 % had a history of AIDS, 20 % had HIV-1 RNA greater than 100,000 copies per mL, 13 % received ABC/3TC and 87 % received FTC/TDF; these characteristics were similar between treatment groups.
Croatian: 3, 84% bili su muškarci, 27% ispitanika nije bilo bijele rase, 4% istodobno je imalo infekciju virusom hepatitisa B i/ili C, 10% imalo je AIDS u anamnezi, 20% imalo je razinu HIV-1 RNK višu od 100 000 kopija/ml, 13% primilo je ABC/3TC te 87% primilo je FTC/TDF; te su značajke bile slične u obje liječene skupine.
English: The antiviral activity of doravirine was not antagonistic when combined with lamivudine and tenofovir disoproxil.
Croatian: Antivirusna aktivnost doravirina nije bila antagonistička kada se on primjenjivao u kombinaciji s lamivudinom i tenofovirdizoproksilom.
English: Excipient with known effect Each film-coated tablet contains 8.6 mg lactose (as monohydrate).
Croatian: Jedna filmom obložena tableta sadrži 8,6 mg laktoze (u obliku hidrata).
English: The M184I/V lamivudine resistance substitution confers resistance to emtricitabine.
Croatian: Supstitucija M184I/V, koja uzrokuje rezistenciju na lamivudin, dovodi do rezistencije na emtricitabin.
English: Doravirine has been evaluated in a limited number of patients with NNRTI resistance (K103N n = 7, G190A n = 1); all patients were suppressed to < 40 copies/mL at Week 48.
Croatian: Doravirin se ocjenjivao kod ograničenog broja bolesnika s rezistencijom na NNRTI-je (K103N n=7, G190A n=1); svim je bolesnicima razina HIV-1 RNK u 48. tjednu bila suprimirana na < 40 kopija/ml.
English: In HIV-1-infected subjects, total clearance was 398.5 ± 69.1 mL per min (mean ± SD).
Croatian: Ukupni klirens u ispitanika s HIV-1 infekcijom iznosio je 398,5 ± 69,1 ml/min (srednja vrijednost ± standardno odstupanje).
English: Lamivudine There are no significant or clinically relevant racial differences in pharmacokinetics of lamivudine.
Croatian: Lamivudin Nema značajnih ni klinički značajnih razlika u farmakokinetici lamivudina s obzirom na rasu.
English: Delstrigo should not be initiated in patients with estimated CrCl < 50 mL/min (see sections 4.4 and 5.2).
Croatian: Delstrigo se ne smije uvoditi u liječenje bolesnicima kojima je procijenjeni CrCl < 50 ml/min (vidjeti dijelove 4.4 i 5.2).
English: Studies in pregnant rats and rabbits showed that doravirine is transferred to the foetus through the placenta, with foetal plasma concentrations of up to 40 % (rabbits) and 52 % (rats) that of maternal concentrations observed on gestation Day 20.
Croatian: Ispitivanja provedena na skotnim ženkama štakora i kunića pokazala su da se doravirin prenosi na plod kroz posteljicu i postiže koncentracije u plazmi ploda koje iznose do 40% (kunići) odnosno 52% (štakori) koncentracija zabilježenih u skotnih ženki 20. dana gestacije.
English: In DRIVE-AHEAD, a lower proportion of subjects who discontinued due to an adverse event by Week 48 was seen for the Delstrigo group (3.0 %) compared with the EFV/FTC/TDF group (6.6 %).
Croatian: U ispitivanju DRIVE-AHEAD zabilježen je manji udio ispitanika koji su prekinuli liječenje zbog nuspojave do 48. tjedna u skupini liječenoj lijekom Delstrigo (3,0%) u usporedbi s onom koja je primala EFV/FTC/TDF (6,6%).
English: • modafinil (a medicine to treat excessive sleepiness)
Croatian: • modafinil (lijek za liječenje prekomjerne pospanosti)
English: Treatment emergent doravirine resistance associated substitutions may confer cross-resistance to efavirenz, rilpivirine, nevirapine, and etravirine.
Croatian: Supstitucije povezane s rezistencijom na doravirin koje se javljaju tijekom liječenja mogu dovesti do križne rezistencije na efavirenz, rilpivirin, nevirapin i etravirin.
English: Animal studies with lamivudine showed an increase in early embryonic deaths in rabbits but not in rats (see section 5.3).
Croatian: Ispitivanja lamivudina na životinjama pokazala su porast stope rane smrti zametaka u kunića, ali ne i u štakora (vidjeti dio 5.3).
English: Doravirine pharmacokinetics are similar in healthy subjects and HIV-1-infected subjects.
Croatian: Farmakokinetika doravirina slična je u zdravih ispitanika i onih s HIV-1 infekcijom.
English: Following a single 245 mg dose of tenofovir disoproxil, a 4-hour hemodialysis session removed approximately 10 % of the administered tenofovir dose.
Croatian: Nakon primjene jednokratne doze tenofovirdizoproksila od 245 mg, 4-satnom hemodijalizom uklonjeno je približno 10% primijenjene doze tenofovirdizoproksila.
English: A documented absence of genotypic resistance (prior to starting first therapy) to doravirine, lamivudine, and tenofovir was part of the inclusion criteria for patients who switched from a PI- or INI-based regimen.
Croatian: Dokumentirana odsutnost genotipske rezistencije (prije uvođenja prve terapije) na doravirin, lamivudin i tenofovir bila je dio kriterija uključivanja za bolesnike koji su prešli s režima temeljenog na inhibitoru proteaze ili inhibitoru integraze.
English: The K65R substitution in HIV-1 RT selected by tenofovir is also selected in some HIV-1 infected patients treated with abacavir or didanosine.
Croatian: Supstitucija K65R u reverznoj transkriptazi HIV-1 izdvojena tenofovirom izdvojena je i u nekih bolesnika s HIV-1 infekcijom liječenih abakavirom ili didanozinom.
English: Tenofovir disoproxil was mutagenic in the in vitro mouse lymphoma assay and negative in an in vitro bacterial mutagenicity test (Ames test).
Croatian: Tenofovirdizoproksil bio je mutagen u testu na mišjem limfomu in vitro te negativan u testu bakterijske mutagenosti (Amesov test) in vitro.
English: Therefore, caution should be used when co-administering doravirine with medicinal products that are sensitive CYP3A substrates that also have a narrow therapeutic window (e.g., tacrolimus and sirolimus).
Croatian: Stoga je potreban oprez kada se doravirin primjenjuje istodobno s lijekovima koji su CYP3A osjetljivi supstrati i koji uz to imaju i usku terapijsku širinu (npr. takrolimus i sirolimus).
English: However, tenofovir disoproxil reduced the viability index and weight of pups in a peri-postnatal toxicity study at maternally toxic doses.
Croatian: Međutim, tenofovirdizoproksil smanjio je indeks vijabilnosti i tjelesnu težinu mladunčadi u ispitivanju perinatalne i postnatalne toksičnosti pri dozama koje su bile toksične za skotnu ženku.
English: Subjects whose virus expressed an L74V RT substitution without zidovudine resistance-associated substitutions (n = 8) had reduced response to tenofovir disoproxil.
Croatian: Ispitanici čiji je virus eksprimirao supstituciju L74V u reverznoj transkriptazi, bez supstitucija povezanih s rezistencijom na zidovudin (n=8), imali su smanjen odgovor na tenofovirdizoproksil.
English: • decreased number of red blood cells in your blood (anaemia)
Croatian: • smanjen broj crvenih krvnih stanica u krvi (anemija)
English: There are no or limited amount of data from the use of doravirine in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni doravirina u trudnica ograničeni.
English: Tenofovir diphosphate inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5´-triphosphate and, after incorporation into DNA, by DNA chain termination.
Croatian: Tenofovirdifosfat inhibira djelovanje reverzne transkriptaze HIV-1 kompeticijom s prirodnim supstratom deoksiadenozin 5´-trifosfatom te, nakon ugradnje u DNK, prekidanjem lanca DNK.
English: Laboratory strains of HIV-1 harbouring the common NNRTI-associated mutations K103N, Y181C, or K103N/Y181C substitutions in RT exhibit less than a 3-fold decrease in susceptibility to doravirine compared to wild-type virus when evaluated in the presence of 100 % normal human serum.
Croatian: Laboratorijski sojevi HIV-1 koji nose česte mutacije povezane s rezistencijom na NNRTI-je (K103N, Y181C) ili supstitucije K103N/Y181C u reverznoj transkriptazi pokazuju manje nego trostruko smanjenje osjetljivosti na doravirin u odnosu na virus divljeg tipa kada su se ispitivali u prisutnosti 100%-tnog normalnog humanog seruma.
English: Co-administration with the moderate CYP3A inducer rifabutin decreased doravirine concentrations (see Table 1).
Croatian: Istodobna primjena s umjerenim induktorom CYP3A rifabutinom snizila je koncentracije doravirina (vidjeti Tablicu 1).
English: Following oral administration of a single 245 mg dose of tenofovir disoproxil to HIV-1-infected subjects in the fasted state, Cmax was achieved in one hour.
Croatian: Nakon peroralne primjene jednokratne doze tenofovirdizoproksila od 245 mg natašte u ispitanika s HIV-1 infekcijom, Cmax je postignut za sat vremena.
English: The median EC50 values of lamivudine were 60 nM (range: 20 to 70 nM), 35 nM (range: 30 to 40 nM), 30 nM (range: 20 to 90 nM), 20 nM (range: 3 to 40 nM), 30 nM (range: 1 to 60 nM), 30 nM (range: 20 to 70 nM), 30 nM (range: 3 to 70 nM), and 30 nM (range: 20 to 90 nM) against HIV-1 clades A-G and group O viruses (n = 3 except n = 2 for clade B) respectively.
Croatian: Medijan vrijednosti EC50 za lamivudin iznosio je 60 nM (raspon: 20 - 70 nM), 35 nM (raspon: 30 - 40 nM), 30 nM (raspon: 20 - 90 nM), 20 nM (raspon: 3 - 40 nM), 30 nM (raspon: 1 - 60 nM), 30 nM (raspon: 20 - 70 nM), 30 nM (raspon: 3 - 70 nM) i 30 nM (raspon: 20 - 90 nM) protiv podtipova A - G virusa HIV-1 i virusa iz skupine O (n=3, osim n=2 za podtip B).
English: Some examples include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs (see section 4.4).
Croatian: Neki primjeri uključuju, ali ne isključivo, aciklovir, cidofovir, ganciklovir, valaciklovir, valganciklovir, aminoglikozide (npr. gentamicin) i visoke doze ili više NSAIL-ova primijenjenih istovremeno (vidjeti dio 4.4).
English: Rare musculoskeletal pain, osteomalacia (manifested as bone pain and infrequently contributing to fractures)*, myopathy*
Croatian: rijetko bol u mišićima i kostima, osteomalacija (koja se manifestira kao bol u kostima i ponekad doprinosi prijelomima)*, miopatija*
English: • headache, dizziness, sleepiness
Croatian: • glavobolja, omaglica, pospanost
English: Exclusionary NNRTI substitutions were those listed above (DRIVE-FORWARD and DRIVE-AHEAD), with the exception of substitutions RT K103N, G190A and Y181C (accepted in DRIVE-SHIFT).
Croatian: Isključujuće supstitucije povezane s rezistencijom na NNRTI-je bile su one navedene gore (ispitivanja DRIVE-FORWARD i DRIVE-AHEAD), uz izuzetak supstitucija u reverznoj transkriptazi K103N, G190A i Y181C (prihvaćene u ispitivanju DRIVE-SHIFT).
English: • sofosbuvir/velpatasvir (medicines used to treat hepatitis C infection)
Croatian: • sofosbuvir/velpatasvir (lijekovi koji se koriste za liječenje infekcije virusom hepatitisa C)