FrancophonIA/ELRC3.0 huggingface dataset:
English: Your healthcare provider will tell you which syringe, or a combination of syringes, to use and will show you (or a caregiver) how to inject Palynziq.
Croatian: Vaš će Vam zdravstveni radnik reći koju štrcaljku, ili koju kombinaciju štrcaljki, primijeniti i pokazati Vam (ili Vašem njegovatelju) kako injicirati Palynziq.
English: • A healthcare provider will monitor you for at least 1 hour after you get Palynziq for signs and symptoms of an allergic reaction.
Croatian: • Zdravstveni radnik će Vas nadzirati najmanje 1 sat nakon primjene lijeka Palynziq zbog moguće pojave znakova i simptoma alergijske reakcije.
English: Use safe disposal procedures for syringes.
Croatian: Koristite postupke za sigurno odlaganje štrcaljki.
English: In clinical trials, 133 out of 285 (47%) patients treated with Palynziq experienced cutaneous reactions (not limited to the injection site) lasting at least 14 days.
Croatian: U kliničkim ispitivanjima, 133 od 285 (47%) bolesnika liječenih lijekom Palynziq imalo je kožne reakcije (koje nisu ograničene na mjesto primjene injekcije) u trajanju od najmanje 14 dana.
English: Of the 261 patients who enrolled in Study 301, 152 patients continued to the eligibility period of Study 302, and 51 patients continued directly from Study 301 into the long-term extension period of Study 302.
Croatian: Od 261 bolesnika uključenog u Ispitivanje 301, 152 bolesnika nastavilo je u razdoblje podobnosti Ispitivanja 302, a 51 bolesnik prešao je iz Ispitivanja 301 izravno u razdoblje dugotrajnog nastavka Ispitivanja 302.
English: • Your doctor will continue to check your blood phenylalanine levels during treatment and may adjust your dose of Palynziq or ask you to change your diet.
Croatian: • Vaš će liječnik nastaviti provjeravati Vaše razine fenilalanina u krvi tijekom liječenja i može prilagoditi dozu lijeka Palynziq ili Vam savjetovati da promijenite prehranu.
English: Four out of 16 (1%; 4/285) patients experienced a total of 5 episodes of acute systemic hypersensitivity reactions that were considered severe (see sections 4.3 and 4.8).
Croatian: Četiri od 16 (1%; 4/285) bolesnika imalo je ukupno 5 epizoda akutne sistemske reakcije preosjetljivosti koje su se smatrale teškim (vidjeti dijelove 4.3 i 4.8).
English: Your doctor will tell you if you can continue Palynziq treatment.
Croatian: Liječnik će Vam reći možete li nastaviti liječenje lijekom Palynziq.
English: The pharmacokinetics of pegvaliase exhibit high inter-patient and intra-patient variability due to the heterogeneity of the immune response in adult patients with PKU.
Croatian: Farmakokinetika pegvaliaze pokazuje visoku varijabilnost između bolesnika i unutar bolesnika zbog heterogenosti imunološkog odgovora u odraslih bolesnika s PKU.
English: Pegvaliase is rAvPAL conjugated with linear 20 kDa NHS-PEG at a degree of substitution of 28 to 44 moles of polymer/mole of protein.
Croatian: Pegvaliaza je rAvPAL konjugiran s linearnim NHS-PEG mase 20 kDa pri stupnju supstitucije od 28 do 44 mola polimera/mol proteina.
English: Dietary phenylalanine intake should remain consistent until a maintenance dose is established.
Croatian: Unos fenilalanina hranom treba ostati dosljedan dok se ne uspostavi doza održavanja.
English: Example of steps to reach your blood phenylalanine goal Palynziq dose and how often to take it
Croatian: Primjeri koraka za postizanje ciljne razine fenilalanina u krvi Doza lijeka Palynziq i koliko često je uzimati
English: • Do not shake or roll the syringe in your hands.
Croatian: • Nemojte tresti ili valjati štrcaljku među dlanovima.
English: These reactions were consistent with a Type III immune-complex mediated hypersensitivity mechanism and were most frequent in the early phases of treatment (during the induction and titration periods) when the early immune response was dominated by PEG IgM, PEG IgG and PAL IgM responses and C3/C4 levels were at their lowest.
Croatian: Te reakcije bile su konzistentne s mehanizmom preosjetljivosti tipa III posredovane imunim kompleksom i najčešće su se javljale u ranoj fazi liječenja (tijekom razdoblja indukcije i titracije) kad su ranim imunološkim odgovorom dominirali odgovori PEG IgM, PEG IgG i PAL IgM, a razine C3/C4 bile najniže.
English: Acute systemic hypersensitivity reactions generally occurred within the first hour after injection (88%; 22/25 episodes); however, reactions have occurred up to 24 hours after dosing.
Croatian: Akutne sistemske reakcije preosjetljivosti najčešće su se javljale unutar prvog sata nakon primjene injekcije (88%; 22/25 epizoda); reakcije su se, međutim, javljale i do 24 sata po primanju doze.
English: Tell your doctor or pharmacist if you are injecting, have recently injected or might inject any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako primjenjujete, nedavno ste primijenili ili biste mogli primijeniti injekcije bilo kojih drugih lijekova.
English: • Before injecting, check to make sure the needle is not damaged or bent.
Croatian: • Prije injiciranja provjerite je li igla oštećena ili savijena.
English: • 1 sharps disposal or puncture resistant container
Croatian: • 1 neprobojan spremnik za odlaganje oštrih predmeta
English: Use your other hand to pinch up the skin around the injection site.
Croatian: Drugom rukom uhvatite nabor kože na mjestu injiciranja.
English: Blood phenylalanine levels should be monitored more frequently prior to and during pregnancy.
Croatian: Razinu fenilalanina u krvi potrebno je češće pratiti prije i tijekom trudnoće.
English: Additional findings in rabbits included increased abortions, foetal malformations and embryo/foetal lethality.
Croatian: Dodatna opažanja u kunića uključivala su povećanje broja pobačaja, fetalne malformacije i smrtnost embrija/fetusa.
English: Keep the adrenaline injection device with you at all times.
Croatian: Uređaj za injekciju adrenalina uvijek nosite sa sobom.
English: Based on animal studies, hypophenylalaninaemia in pregnant women with PKU treated with Palynziq may be associated with adverse foetal outcomes (see sections 4.6 and 5.3).
Croatian: Na temelju istraživanja na životinjama, hipofenilalaninemija u trudnica s PKU liječenih lijekom Palynziq može biti povezana sa štetnim ishodom za fetus (vidjeti dijelove 4.6 i 5.3).
English: Treatment difference in LS mean change (95% CI)
Croatian: Razlika u liječenju u LS srednjoj vrijednosti promjene (95% CI) P-vrijednost2
English: If you have a severe allergic reaction, do not continue to use Palynziq until you have talked with the doctor who prescribes you Palynziq.
Croatian: Ako imate tešku alergijsku reakciju prekinite primjenu lijeka Palynziq dok ne razgovarate s liječnikom koji Vam je propisao lijek.
English: Hypersensitivity reactions that include symptoms such as dizziness or syncope may affect the ability to drive and use machines.
Croatian: Reakcije preosjetljivosti koje uključuju simptome kao što su omaglica ili sinkopa mogu utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Colourless to pale yellow, clear to slightly opalescent solution with pH 6.6 - 7.4.
Croatian: Bezbojna do blijedo žuta, bistra do blago opalescentna otopina pH vrijednosti od 6,6 - 7,4.
English: Three of these patients experienced severe serum sickness (3/285; 1%), which resulted in treatment discontinuation (2 patients) or treatment interruption (1 patient).
Croatian: Od ovih bolesnika tri su imala tešku serumsku bolest (3/285; 1%), što je rezultiralo prestankom liječenja (2 bolesnika) ili privremenim prekidom liječenja (1 bolesnik).
English: Your doctor will tell you how to manage your allergic reactions based on the severity of the reaction, and will prescribe you additional medicines to manage the reaction.
Croatian: Vaš liječnik će Vam reći kako liječiti alergijske reakcije na temelju težine reakcije i propisat će Vam dodatne lijekove za liječenje reakcije.
English: In patients experiencing hypophenylalaninaemia on 10 mg/day, the dose may be reduced to 5 mg/day.
Croatian: U bolesnika u kojih se javi hipofenilalaninemija pri 10 mg/dan, doza se može smanjiti na 5 mg/dan.
English: 5 Complement factor C3/C4 decrease is defined changing from normal or high baseline complement value to low post-baseline complement value.
Croatian: 5 Smanjenje vrijednosti komponente C3/C4 komplementa definira se promjenom vrijednosti komplementa od normalne ili visoke početne vrijednosti do niske vrijednosti komplementa nakon početka ispitivanja.
English: • Do not remove the needle cap until you are ready to inject.
Croatian: • Nemojte skidati kapicu igle dok niste spremni injicirati.
English: Palynziq has a minor influence on the ability to drive and use machines.
Croatian: Palynziq malo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: It will take time to find the dose that works best to lower your blood phenylalanine levels.
Croatian: Bit će potrebno nešto vremena za određivanje doze koja najbolje djeluje na snižavanje Vaše razine fenilalanina u krvi.
English: Talk to your doctor, pharmacist, or nurse before using Palynziq.
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego primijenite Palynziq.
English: • If multiple syringes are needed for a single dose, you should inject at the same time of day.
Croatian: • Ako je za jednu dozu potrebno više štrcaljki, trebate ih primijeniti u isto vrijeme dana.
English: The PKU-POMS confusion subscale (ranging from 0 to 12 points with higher scores indicating greater degree of impairment) was considered most sensitive to changes in blood phenylalanine levels.
Croatian: PKU-POMS podskala konfuzije (u rasponu je od 0 do 12 bodova, veći rezultat ukazuje na veći stupanj poremećaja) smatra se najosjetljivijom na promjene razina fenilalanina u krvi.
English: If your healthcare provider decides that you or your caregiver can give your injections of Palynziq at home, your healthcare provider will show you or your caregiver how to inject Palynziq before you inject it for the first time.
Croatian: Ako Vaš liječnik odluči da Vi ili Vaš njegovatelj možete sami primijeniti injekciju lijeka Palynziq kod kuće, liječnik će Vama i Vašem njegovatelju pokazati kako injicirati lijek prije nego što to učinite prvi put.
English: In clinical trials, serum sickness was reported in 7 out of 285 (2%) patients.
Croatian: U kliničkim ispitivanjima, serumska bolest zabilježena je u 7 od 285 (2%) bolesnika.
English: In Palynziq clinical trials, the majority of patients developed anti-PEG IgM and IgG antibodies after treatment with Palynziq (see section 4.8).
Croatian: U kliničkim ispitivanjima lijeka Palynziq, u većine bolesnika stvorila su se anti-PEG IgM i IgG protutijela nakon liječenja lijekom Palynziq (vidjeti dio 4.8).
English: Because antibodies bind to the PEG portion of pegvaliase, there may be potential for binding with other PEGylated therapeutics and increased hypersensitivity to other PEGylated injectables.
Croatian: S obzirom da se protutijela vežu na PEG dio pegvaliaze, može postojati mogućnost vezanja s drugim pegiliranim terapijskim pripravcima i povećana preosjetljivost na druge pegilirane injekcijske lijekove.
English: Of these 188 patients, 164 patients received treatment for at least 2 years, 2 patients continued treatment but had not yet reached 2 years of treatment, and 22 patients discontinued in the second year, and 9 patients discontinued after 2 years of treatment.
Croatian: Od tih 188 bolesnika, 164 bolesnika primala su lijek najmanje 2 godine, 2 bolesnika nastavila su liječenje ali još nisu dostigla 2 godine liječenja, 22 bolesnika prekinula su liječenje u drugoj godini, a 9 bolesnika prekinulo je liječenje nakon 2 godine.
English: • 1 bandage
Croatian: • 1 zavoj
English: Allergic reactions occur very commonly (may affect more than 1 in 10 people) and range in severity.
Croatian: Alergijske reakcije javljaju se vrlo često (mogu se javiti u više od 1 na 10 osoba) i mogu varirati prema težini.
English: A mean (SD) half-life at 20 mg and 40 mg were 47.3 hours (41.6 hours) and 60.2 hours (44.6 hours), respectively.
Croatian: Srednje vrijednosti (standardna devijacija) poluvijeka pri 20 mg i 40 mg bile su 47,3 sata (41,6 sati) odnosno 60,2 sata (44,6 sati).
English: Animal studies have shown maternal reproductive toxicity that was associated with decreased blood phenylalanine concentrations below normal levels (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su reproduktivnu toksičnost majke koja je bila povezana s koncentracijama fenilalanina u krvi smanjenim ispod normalnih razina (vidjeti dio 5.3).
English: The recommended starting dose of Palynziq is 2.5 mg administered once per week for 4 weeks.
Croatian: Preporučena početna doza lijeka Palynziq je 2,5 mg jednom tjedno tijekom 4 tjedna.
English: However, due to the substantial variability in antibody titres between patients, no specific antibody titre was predictive of pegvaliase dose required to reach substantial blood phenylalanine reduction, or the development of hypophenylalaninaemia.
Croatian: Međutim, zbog značajne varijabilnosti titara protutijela među bolesnicima, niti jedan specifični titar protutijela nije bio pokazatelj za dozu pegvaliaze koja je potrebna za postizanje značajnog smanjenja fenilalanina u krvi ili za razvoj hipofenilalaninemije.
English: The contribution of maternal phenylalanine depletion to the incidence of embryo-foetal developmental effects was not evaluated.
Croatian: Doprinos smanjenja fenilalanina u majke incidencijama embrio-fetalnih razvojnih učinaka nije ispitivan.
English: Step 2: Remove Palynziq tray(s) from carton and check expiry date: - Take out the cartons needed for your dose from the refrigerator.
Croatian: Korak 2: Izvadite podložak(ške) s lijekom Palynziq iz kutije i provjerite rok valjanosti: - Uzmite iz hladnjaka kutije potrebne za dozu koja Vam je propisana.
English: 1 ml pre-filled syringe made of Type I borosilicate glass, equipped with a stainless steel 26 gauge needle, needle safety device, polypropylene plunger rod, and chlorobutyl rubber syringe stopper with fluoropolymer coating.
Croatian: Napunjena štrcaljka od 1 ml napravljena od borosilikatnog stakla tipa I, opremljena iglom od nehrđajućeg čelika veličine 26 gauge, sigurnosni uređaj za iglu, polipropilenski klip štrcaljke i čep od klorobutilne gume s fluoropolimernom oblogom.
English: Step 13: Use your thumb to push in the plunger slowly and steadily as far as it will go to inject all the medicine (see Figure M).
Croatian: Korak 13: Palcem pritišćite klip polako i ravnomjerno do kraja, sve dok ne ubrizgate sav lijek (pogledajte Sliku M).
English: Mean TAb titres peaked 2 weeks after initiation of pegvaliase and then were sustained through long-term treatment (greater than 1 year after treatment initiation).
Croatian: TAb bila je najveća dva tjedna nakon početka primjene pegvaliaze, a potom se održala tijekom dugotrajnog liječenja (više od 1 godine nakon početka liječenja).
English: • Before you inject Palynziq, check each carton and syringe to make sure you have the right pre-filled syringe for your prescribed dose.
Croatian: • Prije injiciranja lijeka Palynziq, provjerite kutiju i štrcaljku kako biste bili sigurni da imate odgovarajuću napunjenu štrcaljku za dozu koja Vam je propisana.
English: If you inject Palynziq with another injectable medicine that contains PEG, such as PEGylated medroxyprogesterone acetate, you may have an allergic reaction.
Croatian: Ako primijenite injekciju lijeka Palynziq s injekcijom drugog lijeka koji sadrži PEG, poput pegiliranog medroksiprogesteronacetata, možete dobiti alergijsku reakciju.
English: Of the 261 enrolled patients, 195 (75%) patients reached their randomised maintenance dose (103 patients in the 20 mg once daily arm, 92 patients in the 40 mg once daily arm).
Croatian: Od 261 uključenog bolesnika, 195 (75%) bolesnika postiglo je svoju randomiziranu dozu održavanja (103 bolesnika u skupini sa 20 mg jednom dnevno, 92 bolesnika u skupini sa 40 mg jednom dnevno).
English: All 16 patients who experienced acute systemic hypersensitivity reactions tested negative for pegvaliase-specific IgE at or near the time of the acute systemic hypersensitivity reactions episode.
Croatian: Svih 16 bolesnika koji su imali akutnu sistemsku reakciju preosjetljivosti bili su negativni na IgE specifičan za pegvaliazu u vrijeme epizode akutne sistemske reakcije preosjetljivosti ili približno u to vrijeme.
English: Figure A below shows what the pre-filled syringe looks like before use.
Croatian: Na slici A u nastavku prikazano je kako izgleda napunjena štrcaljka prije primjene.
English: Twelve patients (11 patients from Study 301) aged 16 up to 18 years received Palynziq treatment.
Croatian: Dvanaest bolesnika (11 bolesnika iz Ispitivanja 301) u dobi od 16 do 18 godina primilo je lijek Palynziq.
English: For at least the first 6 months of treatment when the patient is self-injecting (i.e. when administration is not under healthcare professional supervision), an observer must be present during and for at least 60 minutes after each administration.
Croatian: Najmanje prvih 6 mjeseci liječenja, kad bolesnik sam sebi daje injekcije (tj. kad primjena nije pod nadzorom zdravstvenog radnika), promatrač mora biti prisutan tijekom svake primjene i najmanje 60 minuta nakon svake primjene.
English: Injection site reactions were reported in 266 out of 285 (93%) patients.
Croatian: Reakcije na mjestu primjene injekcije Reakcije na mjestu primjene injekcije zabilježene su u 266 od 285 (93%) bolesnika.
English: Hypersensitivity reactions decreased over time in maintenance as the incidence of these antibodies decreased, and C3/C4 returned towards baseline.
Croatian: Reakcije preosjetljivosti smanjile su se tijekom vremena u fazi održavanja kako je incidencija tih protutijela opala, a vrijednost C3/C4 se vratila na početnu razinu.
English: The underlying mechanism for acute systemic hypersensitivity reactions observed in clinical trials was non-IgE mediated Type III (immune-complex mediated) hypersensitivity (see section 4.8).
Croatian: Mehanizam koji uzrokuje akutne sistemske reakcije preosjetljivosti zabilježene u kliničkim ispitivanjima bila je ne-IgE posredovana preosjetljivost tipa III (preosjetljivost posredovana imunim kompleksom) (vidjeti dio 4.8).
English: Three injection site reactions consistent with granulomatous skin lesions were reported (each reaction occurring in one patient): granulomatous dermatitis (occurred 15 months after Palynziq treatment and lasted 16 days), xanthogranuloma (occurred 12 months after Palynziq treatment and lasted 21 months), and necrobiosis lipoidica diabeticorum (occurred 9 months after Palynziq treatment and lasted 9 months).
Croatian: Zabilježene su tri reakcije na mjestu primjene injekcije konzistentne s granulomatoznim lezijama kože (svaka reakcija pojavila se u jednog bolesnika): granulomatozni dermatitis (pojavio se 15 mjeseci nakon liječenja lijekom Palynziq i trajao je 16 dana), ksantogranulom (pojavio se 12 mjeseci nakon liječenja lijekom Palynziq i trajao je 21 mjesec) i necrobiosis lipoidica diabeticorum (pojavila se 9 mjeseci nakon liječenja lijekom Palynziq i trajala je 9 mjeseci).
English: Five out of the 7 patients who experienced serum sickness continued treatment without a recurrence, and managed serum sickness with treatment interruption, dose reduction and/or concomitant medicinal products.
Croatian: Od 7 bolesnika u kojih se javila serumska bolest, 5 je nastavilo liječenje bez povrata bolesti, a serumska bolest je liječena privremenim prekidom liječenja, smanjenjem doze i/ili popratnim lijekovima.
English: • Do not use the pre-filled syringe if it has been dropped.
Croatian: • Nemojte upotrijebiti napunjenu štrcaljku ako Vam je ispala.
English: Reduced implantations were observed in normal female rats after administration of Palynziq (see section 5.3).
Croatian: Smanjenje broja implantacija opaženo je u normalnih ženskih štakora nakon primjene lijeka Palynziq (vidjeti dio 5.3).
English: If a patient does not reach a clinically relevant blood phenylalanine reduction after 18 months of treatment, continuation should be reconsidered.
Croatian: Ako bolesnik nakon 18 mjeseci liječenja ne postigne klinički značajnu redukciju fenilalanina u krvi, potrebno je razmotriti nastavak liječenja.
English: Of the 261 patients in Study 301, 11 patients were aged between 16 and 18 years at enrolment.
Croatian: Od 261 bolesnika uključenog u Ispitivanje 301, 11 bolesnika bilo je u dobi od 16 do 18 godina u vrijeme uključenja.
English: Driving and using machines Palynziq can affect your ability to drive and use machines if you have a severe allergic reaction.
Croatian: Palynziq može utjecati na Vašu sposobnost upravljanja vozilima i rada sa strojevima ako imate tešku alergijsku reakciju.
English: 10 mg once a week 10 mg twice a week 10 mg four times a week 10 mg daily
Croatian: 10 mg jedanput tjedno 10 mg dvaput tjedno 10 mg četiri puta tjedno 10 mg dnevno
English: 2 Hypersensitivity reactions cover a group of terms, including acute systemic hypersensitivity reactions, and can manifest as a range of symptoms including angioedema, serum sickness, rash, and urticaria.
Croatian: 2 Pojam reakcije preosjetljivosti obuhvaća skupinu pojmova, uključujući akutne sistemske reakcije preosjetljivosti, i može se manifestirati kao niz simptoma poput angioedema, serumske bolesti, osipa i urtikarije.
English: In clinical trials, 241 out of 285 (85%) patients experienced episodes consistent with arthralgia (including back pain, musculoskeletal pain, pain in extremity, and neck pain).
Croatian: U kliničkim ispitivanjima, 241 od 285 (85%) bolesnika imalo je epizode konzistentne s artralgijom (uključujući bol u leđima, mišićno-koštanu bol, bol u ekstremitetu i bol u vratu).
English: • Use each Palynziq pre-filled syringe once only.
Croatian: • Svaku napunjenu štrcaljku lijeka Palynziq primijenite samo jednom.
English: Severe stomach cramps or pain, vomiting, or diarrhoea
Croatian: Teški grčevi ili bol u trbuhu, povraćanje ili proljev
English: Do not inject Palynziq until your healthcare provider has shown you or your caregiver how to inject Palynziq.
Croatian: Nemojte injicirati lijek Palynziq dok liječnik Vama ili Vašem njegovatelju ne pokaže kako injicirati Palynziq.
English: 16 weeks2
Croatian: 16 tjedana2
English: It is very important to keep your phenylalanine levels under control before and during pregnancy.
Croatian: Vrlo je važno držati razine fenilalanina u krvi pod kontrolom prije i tijekom trudnoće.
English: No clinical studies have been conducted to evaluate the effect of renal or hepatic impairment on the pharmacokinetics of pegvaliase.
Croatian: Nisu provedena klinička ispitivanja za procjenu učinka oštećenja funkcije bubrega ili jetre na farmakokinetiku pegvaliaze.
English: • Your doctor will tell you how long to continue taking medicines such as paracetamol, fexofenadine, and/or ranitidine before you take Palynziq.
Croatian: • Liječnik će Vam reći koliko dugo nastaviti uzimati lijekove poput paracetamola, feksofenadina i/ili ranitidina prije primjene lijeka Palynziq.
English: In the peri/postnatal study, pegvaliase decreased pup weight, litter size, and survival of offspring during lactation, and delayed sexual maturation of offspring when administered daily in rats at 20 mg/kg subcutaneously.
Croatian: U peri/postnatalnom ispitivanju, pegvaliaza je smanjila težinu u mladunaca, veličinu legla i preživljavanje potomstva tijekom laktacije te je odgodila seksualno sazrijevanje potomstva kad je dnevno u štakora primijenjena doza od 20 mg/kg supkutano.
English: The purpose of the PEGylation of rAvPAL is to reduce immune recognition of the rAvPAL bacterial protein, and increase the half-life.
Croatian: Svrha pegilacije rAvPAL je smanjiti imunološko prepoznavanje rAvPAL bakterijskog proteina i povećati mu poluvijek.
English: • 44% of patients, 62% of patients, and 66% of patients reached blood phenylalanine level
Croatian: • 44% bolesnika, 62% bolesnika i 66% bolesnika postiglo je koncentraciju fenilalanina u krvi
English: Use that hand to hold the bottom of the syringe steady.
Croatian: Istom rukom čvrsto primite donji dio štrcaljke.