FrancophonIA/ELRC3.0 huggingface dataset:
English: The primary analysis was time from randomisation to first occurrence of a 3-component major adverse cardiovascular event (MACE) defined as cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke.
Slovenian: Primarna analiza je bil čas od randomizacije do prvega pojava katerega od 3 definiranih pomembnih srčno-žilnih neželenih dogodkov (Major Adverse Cardiovascular Events (MACE)): smrti zaradi srčnožilnih zapletov, miokardnega infarkta brez smrtnega izida ali možganske kapi brez smrtnega izida.
English: Treatment with Xultophy should be initiated at the moment the next dose of the long-acting GLP-1 receptor agonist would have been taken.
Slovenian: Zdravljenje z zdravilom Xultophy je treba začeti, ko je načrtovan naslednji odmerek dolgodelujočega agonista receptorjev GLP-1.
English: Furthermore, concomitant illness, especially infections, may lead to hyperglycaemia and thereby cause an increased requirement for antidiabetic treatment.
Slovenian: Spremljajoče bolezni, posebno okužbe, lahko povzročijo hiperglikemijo in zvečajo bolnikovo potrebo po zdravljenju sladkorne bolezni.
English: If a patient wishes to become pregnant, or pregnancy occurs, treatment with Xultophy should be discontinued.
Slovenian: Če bolnica želi zanositi ali zanosi, je treba zdravljenje z zdravilom Xultophy prekiniti.
English: • growth hormone - for low levels of growth hormone
Slovenian: • rastni hormon - uporablja se v primerih pomanjkanja rastnega hormona,
English: If your blood sugar is low or high, your ability to concentrate or react might be affected.
Slovenian: Če imate prenizek ali previsok krvni sladkor, se vam zbranost in sposobnost reagiranja lahko spremenita.
English: Xultophy as add-on to sulfonylurea alone or in combination with metformin were studied in a 26-week randomised, placebo-controlled, double-blind trial.
Slovenian: Zdravilo Xultophy kot dodatek k zdravljenju s sulfonilsečnino, samo ali v kombinaciji z metforminom, so preučevali v 26-tedenskem, randomiziranem, s placebom nadzorovanem, dvojno slepem preskušanju.
English: • The other ingredients are glycerol, phenol, zinc acetate, hydrochloric acid and sodium hydroxide (for pH adjustment), and water for injections.
Slovenian: • Druge sestavine zdravila so glicerol, fenol, cinkov acetat, klorovodikova kislina in natrijev hidroksid (za uravnavanje pH) ter voda za injekcije.
English: If so, the full dose will not be delivered, and you should increase the frequency of checking your blood sugar level.
Slovenian: V tem primeru niste injicirali celotnega odmerka in morate pogosteje kontrolirati koncentracijo krvnega sladkorja.
English: 54.3% of patients treated with Xultophy reached the HbA1c target of <7% without confirmed hypoglycaemic episodes compared to 29.4% of patients treated with insulin glargine (odds ratio 3.24, p<0.001).
Slovenian: Pri zdravljenju z zdravilom Xultophy je ciljno vrednost HbA1c < 7 % brez potrjenih hipoglikemij doseglo 54,3 % bolnikov v primerjavi z 29,4 % bolnikov, ki so se zdravili z insulinom glargin (razmerje obetov 3,24, p<0,001).
English: Be especially aware of the following when using Xultophy:
Slovenian: Pri uporabi zdravila Xultophy bodite še posebej pozorni:
English: They include thirst, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, dry mouth, and loss of appetite as well as acetone odour of breath.
Slovenian: Vključujejo žejo, pogostejše uriniranje, navzeo, bruhanje, zaspanost, pordelo in suho kožo, suha usta, izgubo apetita in acetonski zadah.
English: • Check that the solution in your pen is clear and colourless.
Slovenian: • Preverite, če je raztopina v injekcijskem peresniku bistra in brezbarvna.
English: Liraglutide action is mediated via a specific interaction with GLP-1 receptors and improves glycaemic control by lowering fasting and postprandial blood glucose.
Slovenian: Liraglutid deluje s specifičnim učinkom na receptorje GLP-1 in izboljša urejenost glikemije z zmanjšanjem koncentracije glukoze v krvi na tešče in po obroku.
English: • medicines called ‘glucocorticoids' such as cortisone - for inflammation
Slovenian: • zdravila, imenovana glukokortikoidi (npr. kortizon) - uporabljajo se za zdravljenje vnetja,
English: Some patients with longstanding type 2 diabetes mellitus and heart disease or previous stroke, who were treated with pioglitazone and insulin, experienced the development of heart failure.
Slovenian: Pioglitazon (tablete za zdravljenje sladkorne bolezni tipa 2) Pri nekaterih bolnikih z dolgotrajno sladkorno boleznijo tipa 2 in boleznijo srca ali predhodno možgansko kapjo, ki so se zdravili s pioglitazonom in z insulinom, je prišlo do razvoja srčnega popuščanja.
English: Hypersensitivity to either or both active substances or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na katero od obeh učinkovin ali katero koli pomožno snov, navedeno v poglavju 6.1. 4.4 Posebna opozorila in previdnostni ukrepi
English: Xultophy (dose steps)
Slovenian: Zdravilo Xultophy (odmerni koraki)
English: 1 Prepare your pen with a new needle
Slovenian: 1 Pripravite injekcijski peresnik z novo injekcijsko iglo
English: The rate of nocturnal hypoglycaemic events was similar with Xultophy and insulin degludec treatment.
Slovenian: Delež nočnih hipoglikemičnih dogodkov je bil pri zdravljenju z zdravilom Xultophy podoben kot pri zdravljenju z insulinom degludek.
English: • Take a new needle, and tear off the paper tab.
Slovenian: • Vzemite novo injekcijsko iglo in z nje odstranite papirno nalepko.
English: (cannot be estimated from the available data).
Slovenian: (< 1/10.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: The results were similar for Xultophy and liraglutide.
Slovenian: Podobni rezultati so bili tudi pri primerjavi zdravila Xultophy in liraglutida.
English: In combination with sulfonylurea, the risk of hypoglycaemia may be lowered by a reduction in the dose of sulfonylurea.
Slovenian: Če se zdravilo uporablja v kombinaciji s sulfonilsečnino, se tveganje za pojav hipoglikemije lahko zmanjša z zmanjšanjem odmerka sulfonilsečnine.
English: There is no clinical experience with Xultophy in relation to fertility.
Slovenian: Kliničnih izkušenj z vplivom zdravila Xultophy na plodnost ni.
English: The frequency of nausea and diarrhoea was ‘Common' for Xultophy and ‘Very common' for liraglutide.
Slovenian: Pri uporabi zdravila Xultophy je bila pogostnost navzee in driske v kategoriji “pogosti”, pri uporabi liraglutida pa v kategoriji “zelo pogosti”.
English: This is because the dosing of your Xultophy injections, food or exercise may need to be changed.
Slovenian: Morda bo treba spremeniti odmerek zdravila Xultophy, prehrano ali telesno dejavnost.
English: IDegLira=Xultophy, IDeg=insulin degludec, Lira=liraglutide, obs. rate=observed rate, PYE=patient year of exposure
Slovenian: IDegLira = zdravilo Xultophy, IDeg = insulin degludek, Lira = liraglutid, op. delež = opaženi delež, PYE = bolnikov-let izpostavljenosti
English: FPG (mmol/L)
Slovenian: mmol/L
English: A Endpoints with confirmed superiority of Xultophy vs comparator
Slovenian: A Opazovani dogodki s potrjeno superiornostjo zdravila Xultophy v primerjavi s primerjalnim zdravilom.
English: • monoamine oxidase (MAO) inhibitors - for depression
Slovenian: • zaviralce monoaminooksidaze (zaviralci MAO) - zdravila za zdravljenje depresije,
English: Xultophy is a clear and colourless solution.
Slovenian: Zdravilo Xultophy je bistra in brezbarvna raztopina.
English: Administration of rapid-acting insulin should be considered in situations of severe hyperglycaemia.
Slovenian: V primeru hude hiperglikemije je treba razmisliti o aplikaciji hitrodelujočega insulina.
English: Therefore, the requirement for patients to self-inject is that they can read the dose counter on the pen.
Slovenian: Zato si lahko bolniki injicirajo zdravilo sami le pod pogojem, da lahko odčitajo število enot na števcu odmerka.
English: • acetylsalicylic acid (and medicines called ‘salicylates') - for pain and mild fever
Slovenian: • acetilsalicilno kislino (in zdravila, imenovana salicilati) - zdravila proti bolečinam in rahlo zvišani telesni temperaturi,
English: They may include cold sweats, cool pale skin, fatigue, nervousness or tremor, anxiousness, unusual tiredness or weakness, confusion, difficulty in concentration, drowsiness, excessive hunger, vision changes, headache, nausea and palpitation.
Slovenian: Vključujejo lahko hladno znojenje, hladno in bledo kožo, utrujenost, živčnost ali tresenje, tesnobo, nenavadno utrujenost ali oslabelost, zmedenost, težave s koncentracijo, zaspanost, hudo lakoto, motnje vida, glavobol, navzeo in palpitacije.
English: The pharmacokinetic profile of Xultophy is consistent with once-daily dosing and steady-state concentration of insulin degludec and liraglutide is reached after 2-3 days of daily administration.
Slovenian: Farmakokinetični profil zdravila Xultophy je skladen z odmerjanjem enkrat na dan. Koncentracija insulina degludek in liraglutida v stanju dinamičnega ravnovesja je bila dosežena po 2-3 dneh uporabe enkrat na dan. Porazdelitev
English: Some medicines affect your blood sugar level - this may mean your Xultophy dose has to change.
Slovenian: Nekatera zdravila lahko vplivajo na koncentracijo krvnega sladkorja, zaradi tega pa bo odmerek zdravila Xultophy morda treba spremeniti.
English: Changing the place where you inject each time may reduce the risk of these skin changes.
Slovenian: Z menjavanjem mesta injiciranja pri vsakem injiciranju zdravila lahko zmanjšate tveganje za nastanek takšnih kožnih sprememb.
English: ► High blood sugar (hyperglycaemia)
Slovenian: ► Previsok krvni sladkor (hiperglikemija)
English: Administration of Xultophy may cause formation of antibodies against insulin degludec and/or liraglutide.
Slovenian: Pri uporabi zdravila Xultophy se lahko razvijejo protitelesa proti insulinu degludek in/ali liraglutidu.
English: The pharmacokinetics of liraglutide was evaluated in patients with varying degrees of hepatic impairment in a single-dose trial.
Slovenian: Farmakokinetiko enkratnega odmerka liraglutida so vrednotili v preskušanju pri bolnikih z različnimi stopnjami okvare jeter.
English: The dose steps dialled equal the number shown in the dose counter.
Slovenian: Število izbranih odmernih korakov ustreza številki, prikazani na števcu odmerka.
English: The patient should discard the needle after each injection.
Slovenian: Bolnik mora po vsakem injiciranju injekcijsko iglo zavreči.
English: Before first opening: Store in a refrigerator (2°C - 8°C).
Slovenian: Pred prvim odprtjem: shranjujte v hladilniku (2 °C - 8 °C).
English: 5 After your injection • Lead the needle tip into the outer needle cap on a flat surface without touching the needle or the outer cap.
Slovenian: • Konico igle vstavite v zunanji pokrovček igle na ravni površini, ne da bi se dotaknili igle ali zunanjega pokrovčka igle.
English: The small delay of gastric emptying with liraglutide may influence absorption of concomitantly administered oral medicinal products.
Slovenian: Liraglutid rahlo upočasni praznjenje želodca, kar lahko vpliva na absorpcijo sočasno uporabljenih peroralnih zdravil.
English: In an open label trial comparing the efficacy and safety of Xultophy and insulin glargine 100 units/mL, both as add-on to SGLT2i ± OAD, Xultophy was superior to insulin glargine in reducing mean HbA1c after 26 weeks by 1.9% (from 8.2% to 6.3%) versus 1.7% (from 8.4% to 6.7%) with an estimated treatment difference of -0.36% [-0.50; -0.21].
Slovenian: V odprtem preskušanju, v katerem so primerjali učinkovitost in varnost zdravila Xultophy in insulina glargin v odmerku 100 enot/ml, oba kot dodatek k zdravljenju z zaviralcem natrijevih-glukoznih koprenašalcev 2 (SGLT2) ± peroralnim antidiabetikom, je bilo zdravilo Xultophy po 26 tednih superiorno v primerjavi z insulinom glargin pri zmanjšanju povprečne vrednosti HbA1c; pri uporabi zdravila Xultophy se je vrednost zmanjšala za 1,9 % (z 8,2 % na 6,3 %) v primerjavi z 1,7 % (z 8,4 % na 6,7 %) pri uporabi insulina glargin, z ocenjeno razliko zdravljenja -0,36 % [-0,50; -0,21].
English: Xultophy improves glycaemic control through the sustained lowering of fasting plasma glucose levels and postprandial glucose levels after all meals.
Slovenian: Zdravilo Xultophy izboljša urejenost glikemije s podaljšanim učinkom zniževanja koncentracije glukoze v plazmi na tešče in po vseh obrokih.
English: This may prevent blocked needles, contamination, infection, leakage of solution and inaccurate dosing.
Slovenian: Tako lahko preprečite zamašitev igel, kontaminacijo, okužbo, puščanje raztopine in nenatančno odmerjanje.
English: Insulin (units) Liraglutide (mg) Estimated difference, basal insulin dose
Slovenian: Liraglutid (mg) Ocenjena razlika, odmerek bazalnega insulina
English: IDeg obs. rate
Slovenian: IDeg op. delež
English: The ratio of mitogenic relative to metabolic potency for insulin degludec is unchanged compared to human insulin.
Slovenian: Razmerje mitogene moči v primerjavi s presnovno močjo je pri insulinu degludek podobno kot pri humanem insulinu.
English: Driving and using machines
Slovenian: vožnja vozil ali upravljanje strojev).
English: In patients inadequately controlled on metformin alone or in combination with pioglitazone, Xultophy reduced mean systolic blood pressure by 1.8 mmHg compared to a reduction of 0.7 mmHg with insulin degludec and 2.7 mmHg with liraglutide.
Slovenian: Pri bolnikih z nezadostno urejeno glikemijo pri zdravljenju z metforminom, samim ali v kombinaciji s pioglitazonom, se je povprečna vrednost sistoličnega krvnega tlaka pri uporabi zdravila Xultophy zmanjšala za 1,8 mmHg, v primerjavi z zmanjšanjem za 0,7 mmHg pri uporabi insulina degludek in 2,7 mmHg pri uporabi liraglutida.
English: • Wait until the signs of low blood sugar have gone or when your blood sugar level has settled.
Slovenian: • Počakajte, da znaki prenizkega krvnega sladkorja minejo oziroma se koncentracija krvnega sladkorja ustali, nato pa nadaljujte z običajno uporabo zdravila.
English: Liraglutide
Slovenian: Liraglutid
English: Insulin degludec is a basal insulin that forms soluble multi-hexamers upon subcutaneous injection, resulting in a depot from which insulin degludec is continuously and slowly absorbed into the circulation leading to a flat and stable glucose-lowering effect of insulin degludec with a low day-today variability in insulin action.
Slovenian: Insulin degludek je bazalni insulin, ki po subkutanem injiciranju tvori topne multiheksamere, pri čemer nastane depo, iz katerega se insulin degludek kontinuirano in počasi absorbira v krvni obtok.
English: Animal reproduction studies with insulin degludec have not revealed any differences between insulin degludec and human insulin regarding embryotoxicity and teratogenicity.
Slovenian: Študije o vplivu insulina degludek na sposobnost razmnoževanja pri živalih niso odkrile razlik v embriotoksičnih ali teratogenih učinkih med insulinom degludek in humanim insulinom.
English: The mean daily insulin dose at end of trial was 36 units for patients treated with Xultophy and 54 units for patients treated with insulin glargine.
Slovenian: Ob koncu preskušanja je povprečni dnevni odmerek insulina pri bolnikih, ki so se zdravili z zdravilom Xultophy, znašal 36 enot, pri bolnikih, ki so se zdravili z insulinom glargin, pa 54 enot.
English: Transfer from basal insulin therapies
Slovenian: Prehod z zdravljenja z bazalnim insulinom
English: If you drop it or suspect a problem, attach a new needle and check the flow before you inject.
Slovenian: Če vam je injekcijski peresnik padel ali menite, da je z njim nekaj narobe, pred injiciranjem zdravila zamenjajte iglo in preverite pretok.
English: Liraglutide was superior in preventing MACE vs placebo (Figure 6).
Slovenian: Liraglutid je bil superioren pri preprečevanju pomembnih srčno-žilnih neželenih dogodkov v primerjavi s placebom (slika 6).
English: Store in a refrigerator (2°C to 8°C).
Slovenian: Shranjujte v hladilniku (2 °C − 8 °C).
English: If it shows 50, at least 50 dose steps are left in your pen.
Slovenian: Če števec odmerka kaže 50, je v injekcijskem peresniku na voljo še najmanj 50 odmernih korakov.
English: Xultophy has a stable pharmacodynamic profile with a duration of action reflecting the combination of the individual action profiles of insulin degludec and liraglutide that allows for administration of Xultophy once daily at any time of the day with or without meals.
Slovenian: Trajanje delovanja je odraz kombinacije posameznih profilov delovanja insulina degludek in liraglutida, kar omogoča uporabo zdravila Xultophy enkrat na dan, ob katerem koli času dneva, s hrano ali brez nje.
English: Compared to baseline, there was a mean reduction in body weight of 0.9 kg for Xultophy and a mean increase of 2.6 kg for patients treated with a basal-bolus regimen and the estimated treatment difference was -3.57 kg [95% CI:4.19; -2.95].
Slovenian: V primerjavi z izhodiščem je prišlo pri bolnikih, ki so se zdravili z zdravilom Xultophy, do povprečnega zmanjšanja telesne mase za 0,9 kg ter do povprečnega povečanja telesne mase za 2,6 kg pri bolnikih, ki so bili na bazalno bolusnem režimu zdravljenja: ocenjena razlika zdravljenja je bila -3,57 kg [95 % IZ: -4,19; -2,95].
English: The following substances may reduce the Xultophy requirement:
Slovenian: Potrebo po zdravilu Xultophy lahko zmanjšajo naslednje učinkovine:
English: What Xultophy is and what it is used for What Xultophy is used for
Slovenian: Kaj je zdravilo Xultophy in za kaj ga uporabljamo Za kaj uporabljamo zdravilo Xultophy?
English: • If the pen is damaged or has not been stored correctly (see section 5).
Slovenian: Ne uporabljajte zdravila Xultophy: • če je injekcijski peresnik poškodovan ali ni bil pravilno shranjen (glejte poglavje 5) ali
English: After first opening: Store at a maximum of 30°C or store in a refrigerator (2°C - 8°C).
Slovenian: Po prvem odprtju: shranjujte pri temperaturi do 30 °C ali v hladilniku (2 °C - 8 °C).
English: Adjustment of dose may be necessary if patients undertake increased physical activity, change their usual diet or during concomitant illness.
Slovenian: Pri bolnikih z večjo telesno dejavnostjo, spremembo običajne prehrane ali med sočasnimi boleznimi bo odmerek morda treba prilagoditi.
English: A single dose administration of digoxin 1 mg with liraglutide resulted in a reduction of digoxin AUC by 16%; Cmax decreased by 31%.
Slovenian: Pri uporabi liraglutida skupaj z enkratnim 1-mg odmerkom digoksina se je vrednost AUC digoksina zmanjšala za 16 %, največja koncentracija (Cmax) pa za 31 %.
English: Only the dose counter and dose pointer will show how many dose steps you select per dose.
Slovenian: Le števec in kazalnik odmerka kažeta, koliko odmernih korakov izberete na odmerek.
English: Animal reproduction studies with insulin degludec have not revealed any adverse effects on fertility.
Slovenian: Študije vpliva insulina degludek na sposobnost razmnoževanja pri živalih ne kažejo neželenih učinkov na plodnost.
English: Hold the dose button down until the dose counter shows 0.
Slovenian: Potisni gumb držite pritisnjen, dokler števec odmerka ne pokaže 0.
English: Glycerol, phenol, zinc acetate, hydrochloric acid and sodium hydroxide (for pH adjustment), and water for injections
Slovenian: glicerol, fenol, cinkov acetat, klorovodikovo kislino in natrijev hidroksid (za uravnavanje pH) ter vodo za injekcije.
English: PARTICULARS TO APPEAR ON THE INNER PACKAGING CARTON FOR MULTIPACK
Slovenian: PODATKI NA NOTRANJI OVOJNINI ŠKATLA ZA PAKIRANJE PO VEČ ENOT
English: The 95% confidence interval is stated in ‘[]' *Confirmed hypoglycaemia defined as severe hypoglycaemia (episode requiring assistance of another person) and/or minor hypoglycaemia (plasma glucose <3.1 mmol/L irrespective of symptoms)
Slovenian: *Potrjena hipoglikemija je bila opredeljena kot huda hipoglikemija (dogodek pri katerem je potrebna pomoč druge osebe) in/ali blažja hipoglikemija (koncentracija glukoze v plazmi < 3,1 mmol/l ne glede na simptome).
English: Body weight was reduced by 0.4 kg with an estimated treatment difference between Xultophy and insulin degludec of -2.80 kg (p<0.0001), and the rate of confirmed hypoglycaemia remained 1.8 events per patient year of exposure maintaining a significant reduction in overall risk of confirmed hypoglycaemia compared to insulin degludec.
Slovenian: Telesna masa se je zmanjšala za 0,4 kg, z ocenjeno razliko zdravljenja med zdravilom Xultophy in insulinom degludek -2,80 kg (p<0,0001), delež potrjene hipoglikemije pa je ostal 1,8 dogodkov na bolnikov-let izpostavljenosti.
English: Neonatal growth was reduced in rats while exposed to liraglutide, and persisted in the post-weaning period in the high dose group.
Slovenian: Pri podganah, ki so bile izpostavljene liraglutidu, se je upočasnila neonatalna rast, kar se je v skupini, ki je prejemala velik odmerek, nadaljevalo tudi v obdobju po odstavitvi.
English: Liraglutide reduces body weight and body fat mass through mechanisms involving reduced hunger and lowered energy intake.
Slovenian: Liraglutid preko mehanizmov, med katerimi sta zmanjšanje občutka lakote in manjši vnos energije,
English: Xultophy pre-filled pen and needle (example)
Slovenian: Napolnjen injekcijski peresnik Xultophy in injekcijska igla (primer)
English: Pack sizes of 1, 3, 5 and a multipack containing 10 (2 packs of 5) pens of 3 mL.
Slovenian: Pakiranja z 1, s 3 in 5 napolnjenimi injekcijskimi peresniki s 3 ml ter pakiranje po več enot, ki vsebuje 10 napolnjenih injekcijskih peresnikov s 3 ml (2 pakiranji po 5).
English: Examples dose steps selected dose steps selected
Slovenian: izbranih 5 odmernih korakov izbranih 24 odmernih korakov
English: • Hives (red bumps on your skin that are sometimes itchy).
Slovenian: • koprivnica (rdeči, izbokli kožni izpuščaji, ki lahko srbijo)
English: IDegLira=Xultophy, IDeg=insulin degludec
Slovenian: IDegLira=zdravilo Xultophy, IDeg=insulin degludek
English: A single dose administration of lisinopril 20 mg with liraglutide resulted in a reduction of lisinopril AUC by 15%; Cmax decreased by 27%.
Slovenian: Pri uporabi liraglutida skupaj z enkratnim 20-mg odmerkom lizinoprila se je vrednost AUC lizinoprila zmanjšala za 15 %, največja koncentracija (Cmax) pa za 27 %.
English: The blood glucose-lowering effect of insulin degludec is due to the facilitated uptake of glucose following the binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver.
Slovenian: Insulin degludek znižuje koncentracijo glukoze v krvi tako, da po vezavi insulina na receptorje na mišičnih in maščobnih celicah olajša privzem glukoze, hkrati pa zavre tudi sproščanje glukoze iz jeter.
English: Figure 1 Mean HbA1c (%) by treatment week (left) and rate of confirmed hypoglycaemia per patient year of exposure vs mean HbA1c (%) (right) in patients with type 2 diabetes mellitus inadequately controlled on metformin alone or in combination with pioglitazone
Slovenian: Slika 1: Povprečna vrednost HbA1c (%) po tednih zdravljenja (levo) in delež potrjene hipoglikemije na bolnikov-let izpostavljenosti v primerjavi s povprečno vrednostjo HbA1c (%) (desno) pri bolnikih z nezadostno urejeno sladkorno boleznijo tipa 2 pri zdravljenju z metforminom, samim ali v kombinaciji s pioglitazonom
English: • Skin changes where you give the injection (‘lipodystrophy') - the fatty tissue under the skin may shrink (‘lipoatrophy') or get thicker (‘lipohypertrophy').
Slovenian: • spremembe kože na mestu injiciranja zdravila (lipodistrofija); podkožno maščevje se na mestu injiciranja lahko skrči (lipoatrofija) ali zadebeli (lipohipertrofija).
English: Overall, the pharmacokinetics of insulin degludec and liraglutide were not affected in a clinically relevant manner when administered as Xultophy compared with independent injections of insulin degludec and liraglutide.
Slovenian: Farmakokinetika insulina degludek in liraglutida se pri uporabi zdravila Xultophy klinično pomembno ne razlikuje v primerjavi z uporabo insulina degludek in liraglutida v obliki ločenih injekcij.