FrancophonIA/ELRC3.0 huggingface dataset:
English: Do not store above 25C.
Slovenian: Shranjujte pri temperaturi do 25C.
English: As a result, plasma levels of homocysteine should decrease in these patients, to 20-30 % of pre-treatment levels.
Slovenian: Posledično naj bi se plazemska koncentracija homocisteina pri teh bolnikih znižala na 20-30 % ravni pred zdravljenjem.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Slovenian: Zahteve glede predložitve rednega posodobljenega poročila o varnosti zdravila za to zdravilo so določene v seznamu referenčnih datumov EU (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES in vseh kasnejših posodobitvah, objavljenih na evropskem spletnem portalu o zdravilih.
English: The steady-state response usually occurs within a month.
Slovenian: Odziv v stanju dinamičnega ravnovesja se običajno pojavi v enem mesecu.
English: In that case your doctor will monitor your methionine level in your body and may review your diet.
Slovenian: V takem primeru bo zdravnik spremljal koncentracijo metionina v vašem telesu in še enkrat pretehtal vašo dieto.
English: Your doctor may adapt the dose depending on your laboratory values.
Slovenian: Zdravnik bo morda odmerek prilagodil glede na vrednosti laboratorijskih preiskav.
English: Date of first authorisation: 15 February 2007 Date of latest renewal: 21 November 2016
Slovenian: Datum zadnjega podaljšanja: 21 november 2016
English: Do not stop the treatment without consulting your doctor.
Slovenian: Ne prenehajte z zdravljenjem brez predhodnega posvetovanja z zdravnikom.
English: Methionine levels should be closely monitored in these patients.
Slovenian: Pri teh bolnikih je treba ravni metionina pozorno spremljati.
English: • 5,10-methylene-tetrahydrofolate reductase (MTHFR),
Slovenian: • 5,10-metilentetrahidrofolat reduktaze (MTHFR),
English: Your treatment with Cystadane may need to be interrupted.
Slovenian: Mogoče bo treba vaše zdravljenje z zdravilom Cystadane prekiniti.
English: The aim of treatment is to keep plasma levels of total homocysteine below 15 µM or as low as possible.
Slovenian: Cilj zdravljenja je obdržati koncentracijo celotnega homocisteina v plazmi pod 15 µM ali tako nizko, kolikor je mogoče.
English: • take the correct measuring spoon:
Slovenian: • Vzemite pravilno merilno žličko:
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Slovenian: Če ste noseči ali dojite, menite, da ste noseči ali načrtujete zanositev, se posvetujte z zdravnikom, preden vzamete to zdravilo.
English: Complete recovery was seen after treatment discontinuation (see section 4.4).
Slovenian: Po prekinitvi zdravljenja je prišlo do popolnega okrevanja (glejte poglavje 4.4).
English: Betaine anhydrous was rapidly distributed into a relatively large volume (V/F = 1.3 l/kg).
Slovenian: Brezvodni betain se je hitro porazdelil po razmeroma velikem prostoru (V/F = 1,3 l/kg).
English: If methionine increases particularly above the first safety threshold of 700 µmol/L, patient should be monitored more frequently and compliance with diet should be checked.
Slovenian: Če se raven metionina poveča, zlasti če se poveča nad prvo varnostno mejo 700 µmol/l, je treba bolnika spremljati pogosteje in ugotoviti, ali se drži diete.
English: What Cystadane is and what it is used for
Slovenian: Kaj je zdravilo Cystadane in za kaj ga uporabljamo
English: • cystathionine beta-synthase (CBS),
Slovenian: • cistationin beta-sintaze (CBS),
English: - There is no other ingredient.
Slovenian: - Zdravilo ne vsebuje drugih sestavin.
English: The extent of this effect was dependent on the absolute degree of hyperhomocysteinemia, being higher in severe hyperhomocysteinemia.
Slovenian: Obseg tega učinka je bil odvisen od absolutne stopnje hiperhomocisteinemije in je bil večji pri težki hiperhomocisteinemiji.
English: The pharmacokinetic data of homocystinuric patients on long-term betaine anhydrous supplementation are very similar to those of healthy volunteers.
Slovenian: Farmakokinetični podatki bolnikov s homocistinurijo, ki dolgoročno prejemajo dodatek brezvodnega betaina, so zelo podobni kot pri zdravih prostovoljcih.
English: In a few cases, increased plasma methionine levels were associated with cerebral oedema (see sections 4.4 and 4.8).
Slovenian: V nekaj primerih so bili povišani nivoji metionina v plazmi povezani s cerebralnim edemom (glejte točki 4.4 in 4.8).
English: • take the correct number of spoonfuls of powder from the bottle
Slovenian: • Vzemite pravilno število žličk praška iz steklenice.
English: Very common: blood methionine increased*
Slovenian: Zelo pogosta: zvišan metionin v krvi*
English: Other medicines and Cystadane
Slovenian: Druga zdravila in zdravilo Cystadane
English: Uncommon: anorexia
Slovenian: Občasna: anoreksija
English: After a repeated dose regiment of 100 mg/kg/day for 5 days, the distribution half life was prolonged significantly (up to 36 h), indicating saturable transport and redistribution processes.
Slovenian: Po shemi ponavljajočih se odmerkov po 100 mg/kg/dan 5 dni se je razpolovni čas porazdelitve signifikantno podaljšal (do 36 ur), kar kaže na to, da se procesi transporta in ponovne porazdelitve nasitijo.
English: The available clinical data do not allow correlating posology and clinical efficacy.
Slovenian: Klinični podatki, ki so na voljo, ne omogočajo koreliranja odmerjanja in klinične učinkovitosti.
English: Methionine is present in regular food protein (e.g. meat, fish, milk, cheese, eggs).
Slovenian: Metionin je aminokislina, prisotna v običajnih beljakovinah v hrani (npr. mesu, ribah, siru, jajcih).
English: Fertility No data is available.
Slovenian: Plodnost Podatki niso na voljo.
English: Adjunctive treatment of homocystinuria, involving deficiencies or defects in:
Slovenian: Dodatno zdravljenje homocistinurije, ki obsega pomanjkanje ali napake:
English: • cobalamin cofactor metabolism (cbl).
Slovenian: • presnove kofaktorjev kobalamina (cbl).
English: It is recommended to measure plasma methionine level at start of treatment and about annually or biannually thereafter.
Slovenian: Priporočljivo je izmeriti raven metionina na začetku zdravljenja in nato približno enkrat na leto ali enkrat na dve leti.
English: To measure the dose:
Slovenian: Odmerek odmerite takole:
English: If you take more Cystadane than you should If you accidentally take too much Cystadane, talk to a doctor or pharmacist immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Cystadane, kot bi smeli Če po nesreči vzamete preveč zdravila Cystadane, se takoj pogovorite z zdravnikom ali farmacevtom.
English: The bottle should be lightly shaken before opening.
Slovenian: Steklenico je treba pred odpiranjem rahlo pretresti.
English: In paediatric patients less than 10 years of age, the usual effective dose regimen is 100 mg/kg/day given in 2 doses daily; increasing the frequency above twice daily and/or the dose above 150 mg/kg/day does not improve the homocysteine-lowering effect.
Slovenian: Pri pediatričnih bolnikih, mlajših od 10 let, je običajna učinkovita shema odmerjanja 100 mg/kg/dan, danih v 2 odmerkih na dan; če zdravilo dajemo pogosteje kot dvakrat na dan in/ali zvečamo odmerek nad 150 mg/kg/dan, se učinkovitost zdravila glede zniževanja homocisteina ne izboljša.
English: Uncommon: urinary incontinence
Slovenian: Občasna: inkontinenca urina
English: After a repeated dose regimen of 100 mg/kg/day for 5 days, the absorption kinetics did not change.
Slovenian: Po shemi ponavljajočih se odmerkov po 100 mg/kg/dan 5 dni se kinetika absorpcije ni spremenila.
English: In some patients doses above 200 mg/ kg/day were needed to reach therapeutic goals.
Slovenian: Pri nekaterih bolnikih so za doseganje terapevtskih ciljev bili potrebni odmerki nad 200 mg/kg/dan.
English: The most commonly side effect when taking Cystadane which may affect more than 1 in 10 people (frequency very common) is elevated levels of methionine in the blood.
Slovenian: Najpogostejši neželeni učinek pri jemanju zdravila Cystadane, ki se lahko pojavi pri več kot 1 od 10 bolnikov (zelo pogosto) je zvišana raven metionina v krvi.
English: In order to reduce methionine levels, modification of diet as well as dose reduction of Cystadane or temporal interruption of Cystadane treatment should be considered.
Slovenian: Za zmanjšanje ravni metionina je treba razmisliti o spremembi diete in zmanjšanju odmerka zdravila Cystadane ali začasni prekinitvi zdravljenja z zdravilom Cystadane.
English: Reported adverse reactions are listed below, by system organ class and by frequency.
Slovenian: V nadaljevanju so neželeni učinki, o katerih so poročali, navedeni po organskih sistemih in po pogostnosti.
English: The use of this medicine will be supervised by a doctor experienced in the treatment of patients with homocystinuria.
Slovenian: Uporabo tega zdravila bo nadzoroval zdravnik, izkušen v zdravljenju bolnikov s homocistinurijo.
English: In most cases, adding betaine anhydrous resulted in a further reduction in plasma homocysteine level.
Slovenian: Pri večini primerov je imel dodatek brezvodnega betaina za posledico nadaljnje znižanje ravni homocisteina v plazmi.
English: Monitoring betaine plasma concentrations does not help to define the efficacy of treatment, since these concentrations do not directly correspond to the flux through the cytosolic betaine homocysteine methyl transferase pathway.
Slovenian: Spremljanje koncentracije betaina v plazmi ne pomaga pri opredeljevanju učinkovitosti zdravljenja, ker se te koncentracije ne ujemajo neposredno s tokom skozi citosolno betainsko-homocisteinsko metiltransferazno presnovno pot.
English: Pharmacotherapeutic group: Other alimentary tract and metabolism products, ATC code: A16AA06.
Slovenian: Farmakoterapevtska skupina: Druga zdravila za zdravljenje bolezni prebavil in presnove, oznaka ATC: A16A A06.
English: Other uncommon side effects (may affect up to 1 in 100 people) may include decreased appetite (anorexia), agitation, irritability, hair loss, hives, skin odour abnormal, lack of control over passing urine (urinary incontinence).
Slovenian: Drugi občasni neželeni učinki (pojavijo se lahko pri 1 od 100 bolnikov) lahko vključujejo zmanjšanje apetita (anoreksijo), vznemirjenost, razdražljivost, izpadanje las, koprivnico, nenavaden vonj kože, nesposobnost nadziranja urina (urinska inkontinenca).
English: Hypersensitivity to the active substance.
Slovenian: Preobčutljivost na zdravilno učinkovino.
English: It is converted into homocysteine which is then normally converted into cysteine during digestion.
Slovenian: Spremeni se v homocistein, ta pa nato med prebavo normalno naprej v cistein.
English: The most commonly reported adverse reaction during treatment is blood methionine increased.
Slovenian: Neželeni učinek, o katerem so med zdravljenjem poročali najpogosteje, je povečanje metionina v krvi.
English: In observational studies, clinical improvement (cardiovascular and neurodevelopmental) was reported by the treating physician in about 75% of patients taking betaine anhydrous.
Slovenian: Pri opazovalnih študijah je lečeči zdravnik poročal o kliničnem izboljšanju (tako kardiovaskularnem kot glede razvoja živčevja) pri okrog 75 % bolnikov, ki so jemali brezvodni betain.
English: This demonstrates that differences in betaine anhydrous kinetics are most probably due to betaine anhydrous depletion in untreated homocystinuria and are only meaningful for the initial treatment.
Slovenian: To kaže, da so razlike v kinetiki brezvodnega betaina najverjetneje posledica izčrpanja brezvodnega betaina pri nezdravljeni homocistinuriji in so pomembne samo za začetno zdravljenje.
English: What you need to know before you take Cystadane
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Cystadane
English: Complete recovery was seen after treatment discontinuation: - The plasma methionine concentrations should be kept below 1000 µM.
Slovenian: Po prekinitvi zdravljenja so bolniki popolnoma okrevali: - Koncentracija metionina v plazmi mora biti nižja od 1000 µM.
English: During pregnancy, administering betaine anhydrous in addition to pyridoxine, folate, anticoagulant and diet under close monitoring of plasma homocysteine would be compatible with good maternal and foetal outcomes.
Slovenian: V nosečnosti bi bila uporaba brezvodnega betaina kot dodatek piridoksinu, folatu, antikoagulantu in dieti ob pazljivem spremljanju homocisteina v plazmi združljiva z ugodnim izidom za mater in plod.
English: It is likely that due to the multiple nature of therapy (dietary, pharmaceutical, supportive) in these patients, there may be an element of overestimation in the clinical effects of betaine anhydrous treatment.
Slovenian: Pri teh bolnikih zaradi večtirnosti zdravljenja (zdravljenje z dieto, z zdravili, podporno zdravljenje) verjetno obstaja element precenjevanja kliničnih učinkov zdravljenja z brezvodnim betainom.
English: 5 How to store Cystadane Contents of the pack and other information
Slovenian: 5 Shranjevanje zdravila Cystadane Vsebina pakiranja in dodatne informacije
English: If you experience morning headaches with vomiting and/or visual changes, contact immediately your doctor (they could be signs of a swelling in the brain).
Slovenian: Če opazite jutranji glavobol z bruhanjem in/ali spremembami vida, se takoj posvetujte s svojim zdravnikom (to lahko so znaki otekline možganov).
English: The recommended total daily dose is 100 mg/kg/day given in 2 doses daily.
Slovenian: Priporočeni celotni dnevni odmerek je 100 mg/kg/dan, ki se daje v 2 dnevnih odmerkih.
English: (age between 21 to 49 years), after a single oral dose of betaine anhydrous (50 mg/kg), absorption was rapid (tmax = 0.9 ± 0.3 hours and a Cmax = 0.9 ± 0.2 mM).
Slovenian: Pri zdravih odraslih prostovoljcih (starih med 21 in 49 leti) je bila po enkratnem peroralnem odmerku brezvodnega betaina (50 mg/kg) absorpcija hitra (tmax = 0,9 ± 0,3 ure in Cmax = 0,9 ± 0,2 mM).
English: The powder should be mixed with water, juice, milk, formula or food until completely dissolved and ingested immediately after mixing.
Slovenian: Prašek je treba zmešati z vodo, sadnim sokom, mlekom, formulo ali hrano, da se popolnoma raztopi in ga po mešanju takoj zaužiti.
English: What Cystadane is and what it is used for What do you need to know before you take Cystadane How to take Cystadane
Slovenian: Kaj je zdravilo Cystadane in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Cystadane Kako jemati zdravilo Cystadane Možni neželeni učinki
English: The recommended dose in children and adults is 100mg/kg/day divided in 2 dosesper day.
Slovenian: Priporočeni odmerek pri otrocih in odraslih je 100 mg/kg/dan, razdeljen na 2 odmerka.
English: Uncommon: agitation, irritability
Slovenian: Občasne: agitiranost, razdražljivost
English: Do not use this medicine after the expiry date which is stated on the bottle label and the carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini steklenice in škatli poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: It is not known whether betaine anhydrous is excreted in human milk (although its metabolic precursor, choline, occurs at high levels in human milk).
Slovenian: Ni znano, ali se brezvodni betain izloča v materino mleko (čeprav se njegov presnovni prekurzor, holin, v materinem mleku pojavlja v visokih koncentracijah).
English: Methionine level can be related to swelling in the brain (cerebral swelling), which may affect up to 1 in 100 people (frequency uncommon).
Slovenian: Raven metionina je lahko povezana z oteklino možganov (cerebralna oteklina), ki se lahko pojavi pri 1 od 100 bolnikov (občasna pogostnost).
English: Most of these patients were also receiving other treatments such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin) and folate with variable biochemical responses.
Slovenian: Večina teh bolnikov je prejemala tudi druga zdravila, na primer vitamin B6 (piridoksin), vitamin B12 (kobalamin) in folat, z variabilnimi biokemičnimi odzivi.
English: - If symptoms of cerebral oedema recur after re-introduction of treatment then betaine anhydrous therapy should be discontinued indefinitely.
Slovenian: - Če se po ponovni uvedbi zdravljenja simptomi možganskega edema spet pojavijo, je treba zdravljenje z brezvodnim betainom za vedno opustiti.
English: If you stop taking Cystadane
Slovenian: Če ste prenehali jemati zdravilo Cystadane
English: Cystadane contains betaine anhydrous which is intended to be an adjunctive treatment of homocystinuria, an inherited (genetic) disease where the amino acid methionine cannot be broken down completely by the body.
Slovenian: Zdravilo Cystadane vsebuje brezvodni betain, ki je namenjen dodatnemu zdravljenju homocistinurije, podedovane (genetske) bolezni, pri kateri telo ne more razgraditi aminokisline metionina.
English: 180 g of oral powder.
Slovenian: 180 g peroralnega praška.
English: Mix the measured dose of powder with water, juice, milk, formula or food until completely dissolved and ingest immediately after mixing.
Slovenian: Zmešajte izmerjen odmerek praška z vodo, sadnim sokom, mlekom, formulo ali hrano, da se bo popolnoma raztopil, in ga po mešanju takoj zaužijte.
English: Cystadane has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Cystadane nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: To minimise the risk of potential drug interactions, it is advisable to leave 30 minutes between the intake of betaine anhydrous and amino acids mixtures and/or medicinal products containing vigabatrin and GABA analogues (see section 4.5).
Slovenian: Da se nevarnost možnih interakcij med zdravili čim bolj zmanjša, priporočamo, naj med zaužitjem brezvodnega betaina in mešanic aminokislin ali zdravil, ki vsebujejo vigabatrin in analoge GABA ali obojega, mine 30 minut (glejte poglavje 4.5).
English: Do not take Cystadane If you are allergic to betaine anhydrous.
Slovenian: Ne jemljite zdravila Cystadane če ste vi ali vaš otrok alergični na brezvodni betain.
English: If you are treated with Cystadane and with an amino-acid mixture and if you need to take other medicines at the same time, leave 30 minutes between the intake (see “section “Other medicines and Cystadane”).
Slovenian: Če se zdravite z zdravilom Cystadane in z mešanico aminokislin in morate istočasno jemati še druga zdravila, druga zdravila vzemite šele pol ure ali več po tistem, ko vzamete Cystadane in mešanico aminokislin (glejte poglavje »Druga zdravila in zdravilo Cystadane«).
English: Because of lack of data, caution should be exercised when prescribing Cystadane to breast-feeding women.
Slovenian: Zaradi pomanjkanja podatkov je pri predpisovanju zdravila Cystadane doječim materam potrebna previdnost.
English: Experience with betaine anhydrous therapy in patients with renal insufficiency or non-alcoholic hepatic steatosis has demonstrated no need to adapt the dose regimen of Cystadane.
Slovenian: Izkušnje z zdravljenjem z brezvodnim betainom pri bolnikih z insuficienco ledvic ali nealkoholno steatozo jeter so pokazale, da pri teh bolnikih sheme odmerjanja zdravila Cystadane ni treba prilagajati.
English: Caution should be exercised with up-titrating doses for patients with CBS deficiency due to the risk for hypermethioninaemia.
Slovenian: Pri titriranju odmerka navzgor pri bolnikih s pomanjkanjem CBS je potrebna previdnost zaradi tveganja za hipermetioninemijo.
English: If you are taking amino-acid mixture or medicines such as vigabatrin or Gaba analogues (medicine used to treat epilepsy), please tell your doctor as they might interact with your treatment with Cystadane.
Slovenian: Če jemljete mešanico aminokislin ali zdravila, kakršna sta vigabatrin ali zdravila z zdravilnimi učinkovinami, podobnimi GABA (zdravilo za zdravljenje epilepsije), to povejte zdravniku, ker bi ta zdravila lahko vplivala na vaše zdravljenje z zdravilom Cystadane.
English: Uncommon: brain oedema*
Slovenian: Občasna: možganski edem*
English: Monitoring plasma homocysteine levels has demonstrated that the onset of action of betaine anhydrous occurred within several days and that a steady-state response was achieved within one month.
Slovenian: S spremljanjem koncentracije homocisteina v plazmi so pokazali, da brezvodni betain začne delovati čez nekaj dni in da se odziv v stanju dinamičnega ravnovesja doseže v enem mesecu.
English: The use of Cystadane together with other treatments such as vitamin B6, vitamin B12, folate and a specific diet aims to reduce the elevated homocysteine levels in your body.
Slovenian: Cilj uporabe zdravila Cystadane skupaj z drugimi zdravili in vrstami zdravljenja, kot so vitamin B6, vitamin B12, folat in posebna dieta, je znižanje zvišane koncentracije homocisteina v vašem telesu.
English: • take a heaped spoonful of powder out of the bottle
Slovenian: • Vzemite zvrhano merilno žličko praška iz steklenice.
English: Based on in vitro data, betaine anhydrous might interact with amino acids mixtures and medicinal products containing vigabatrin and GABA analogues.
Slovenian: Na podlagi podatkov, pridobljenih in vitro, bi se lahko pojavile interakcije brezvodnega betaina z mešanicami aminokislin in zdravil, ki vsebujejo vigabatrin in analoge GABA.
English: Betaine anhydrous acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria.
Slovenian: Brezvodni betain deluje kot donator metilnih skupin pri ponovnem metiliranju homocisteina v metionin pri bolnikih s homocistinurijo.
English: Driving and using machines Cystadane has no or negligible influence on the ability to drive and use machines.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Cystadane nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: Cystadane treatment should be supervised by a physician experienced in the treatment of patients with homocystinuria.
Slovenian: Zdravljenje z zdravilom Cystadane naj nadzoruje zdravnik, ki ima izkušnje z zdravljenjem bolnikov s homocistinurijo.
English: Each pack contains 1 bottle with 180 g of powder and three measuring spoons.
Slovenian: Vsaka škatlica vsebuje 1 plastenko s 180 g praška in tri merilne žličke.
English: Description of selected adverse reactions *Uncommon cases of severe cerebral oedema and hypermethioninemia were reported within 2 weeks to 6 months of starting betaine anhydrous therapy in patients with CBS deficiency, with complete recovery after treatment discontinuation.
Slovenian: Opis izbranih neželenih učinkov * Pri bolnikih s pomanjkanjem CBS so poročali o občasnih primerih težkega možganskega edema in hipermetioninemije 2 tednih do 6 mesecih o začetku zdravljenja z brezvodnim betainom; po prekinitvi zdravljenja so bolniki povsem okrevali.
English: Cystadane should be used as supplement to other therapies such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin), folate and a specific diet.
Slovenian: Zdravilo Cystadane naj se uporablja kot dodatek drugim zdravilom, na primer vitaminu B6 (piridoksin), vitaminu B12 (kobalamin), folatu in posebni dieti.
English: Late detection of homocystinuria in symptomatic state is responsible for residual morbidity due to irreversible damage to connective tissue (ophtalmological, skeletal) that cannot be corrected by further therapy.
Slovenian: Pozno odkritje homocistinurije, ko je bolezen že v simptomatskem stadiju, je odgovorno za rezidualno obolevnost zaradi ireverzibilnih okvar vezivnega tkiva (oftalmoloških, skeletnih), ki jih nadaljnje zdravljenje ne more popraviti.
English: HDPE bottles with a child resistant closure.
Slovenian: Plastenke iz HDPE s pokrovčkom z za otroke varno zaporko.
English: EXP Shelf life after the first opening: 3 months.
Slovenian: EXP Rok uporabnosti po prvem odpiranju: 3 mesece.
English: Absorption The absolute bioavailability of betaine anhydrous has not been determined.
Slovenian: Absolutne biološke uporabnosti brezvodnega betaina niso ugotovili.