FrancophonIA/ELRC3.0 huggingface dataset:
English: Levetiracetam and related analogues show a rank order of affinity for binding to the synaptic vesicle protein 2A which correlates with the potency of their anti-seizure protection in the mouse audiogenic model of epilepsy.
Danish: Levetiracetam og beslægtede analoger udviser en rangordnet affinitet for binding til det synaptiske vesikelprotein 2A, som i den audiogene epilepsi-model på mus er korreleret til antikonvulsiv potens.
English: 4 to 16 years, vomiting (very common, 11.2%), agitation (common, 3.4%), mood swings (common, 2.1%), affect lability (common, 1.7%), aggression (common, 8.2%), abnormal behaviour (common, 5.6%), and lethargy (common, 3.9%) were reported more frequently than in other age ranges or in the overall safety profile.
Danish: Hos børn og unge i alderen 4-16 år blev der hyppigere rapporteret om opkastning (meget almindelig, 11,2 %), agitation (almindelig, 3,4 %), humørsvingninger (almindelig, 2,1 %), affektlabilitet (almindelig, 1,7 %), aggression (almindelig, 8,2 %), unormal adfærd (almindelig, 5,6 %) og letargi (almindelig, 3,9 %) end i andre aldersgrupper eller i den samlede sikkerhedsprofil.
English: Furthermore, levetiracetam has been shown in in vitro studies to bind to a specific site in rodent brain tissue.
Danish: Endvidere er det i in vitro-studier påvist, at levetiracetam binder sig til et specifikt sted i hjernevæv hos gnavere.
English: • pancreatitis (inflammation of the pancreas);
Danish: • pankreatitis (betændelse i bugspytkirtlen );
English: This medicinal product contains 2.5 mmol (or 57 mg) sodium per maximum single dose (0.8 mmol (or 19 mg) per vial).
Danish: Dette lægemiddel indeholder 2,5 mmol (57 mg) natrium pr. maksimale enkeltdosis (0,8 mmol (19 mg) pr. hætteglas).
English: • rhabdomyolysis (breakdown of muscle tissue) and associated blood creatine phosphokinase increase.
Danish: • rabdomyolyse (nedbrydning af muskelvæv) forbundet med forhøjet indhold af kreatinkinase i blodet.
English: In this study, the patients received levetiracetam as a fixed dose of 60 mg/kg/day (with twice a day dosing).
Danish: I dette studie fik patienterne levetiracetam i en fast dosis på 60 mg/kg/dag (fordelt på to doser dagligt).
English: A single dose of 1,500 mg levetiracetam diluted in 100 ml of a compatible diluent and infused intravenously over 15 minutes is bioequivalent to 1,500 mg levetiracetam oral intake, given as three 500 mg tablets.
Danish: En enkelt dosis på 1.500 mg levetiracetam fortyndet i 100 ml af en kompatibel fortyndingsvæske og infunderet intravenøst i løbet af 15 minutter er bioækvivalent med 1.500 mg levetiracetam til oral indtagelse, givet som tre 500 mg tabletter.
English: In adults, levetiracetam efficacy has been demonstrated in 3 double-blind, placebo--controlled studies at 1,000 mg, 2,000 mg, or 3,000 mg/day, given in 2 divided doses, with a treatment duration of up to 18 weeks.
Danish: Levetiracetams virkning hos voksne er blevet demonstreret i 3 dobbeltblinde placebokontrollerede studier med hhv. 1.000 mg, 2.000 mg eller 3.000 mg/dag, fordelt på to doser, med en behandlingsvarighed på op til 18 uger.
English: The patients were randomized to carbamazepine CR 400-1,200 mg/day or levetiracetam 1,000-3,000 mg/day, the duration of the treatment was up to 121 weeks depending on the response.
Danish: mg/dag eller levetiracetam 1.000-3.000 mg/dag, varigheden af behandlingen var op til 121 uger afhængigt af respons.
English: Levetiracetam efficacy was established in a 24-week double-blind, placebo-controlled study which included adults, adolescents and a limited number of children suffering from idiopathic generalized epilepsy with primary generalized tonic-clonic (PGTC) seizures in different syndromes (juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, or epilepsy with Grand Mal seizures on awakening).
Danish: Levetiracetams virkning blev påvist i et 24-ugers dobbeltblindt, placebokontrolleret studie, som omfattede voksne og unge samt et begrænset antal børn med idiopatisk generaliseret epilepsi med primært generaliserede tonisk-kloniske anfald (PGTC) i forskellige syndromer (juvenil myoklon epilepsi, juvenil absence epilepsi, børne absence epilepsi eller epilepsi med Grand Mal anfald ved opvågning).
English: A peri- and post-natal development study was performed in rats with levetiracetam doses of 70, 350 and 1,800 mg/kg/day.
Danish: Der blev udført et peri- og postnatalt udviklingsforsøg med doser af levetiracetam på 70, 350 og 1.800 mg/kg/dag i rotter.
English: Levetiracetam Hospira concentrate for solution for infusion is packed in a cardboard box containing 10 or 25 vials of 5 ml.
Danish: Levetiracetam Hospira koncentrat til infusionsvæske, opløsning er pakket i en papæske med 10 eller 25 hætteglas á 5 ml.
English: Your total daily dose and frequency of administration remain identical.
Danish: Den totale daglige dosis og antal indgivelser bør være de samme.
English: In human hepatocytes in culture, levetiracetam had little or no effect on CYP1A2, SULT1E1 or UGT1A1.
Danish: Levetiracetam havde lille eller ingen effekt på CYP1A2, SULT1E1 eller UGT1A 1 i kulturer af humane hepatocytter.
English: The NOAEL was <200 mg/kg/day for the dams and 200 mg/kg/day for the foetuses (equal to the MRHD on a mg/m2 basis).
Danish: NOAEL var < 200 mg/kg/dag for hunnerne og 200 mg/kg/dag for fostrene (svarende til MRHD på basis af mg/m
English: Talk to your doctor before you are given Levetiracetam Hospira:
Danish: Kontakt lægen, før du tager Levetiracetam Hospira:
English: Depending upon the clinical response and tolerability, the daily dose can be increased up to 1,500 mg twice daily.
Danish: Afhængigt af klinisk effekt og tolerabilitet kan den daglige dosis øges til 1.500 mg to gange dagligt.
English: In this study, levetiracetam dose was 3,000 mg/day for adults and adolescents or 60 mg/kg/day for children, given in 2 divided doses.
Danish: I dette studie var levetiracetam-dosis 3.000 mg/dag for voksne og unge og 60 mg/kg/dag for børn, fordelt på 2 doser.
English: In paediatric patients (4 to 16 years of age), levetiracetam efficacy was established in a double-blind, placebo-controlled study, which included 198 patients and had a treatment duration of 14 weeks.
Danish: Levetiracetams virkning hos pædiatriske patienter (4-16 år) blev vist i et dobbeltblindt placebokontrolleret studie med 198 patienter og en behandlingsvarighed på 14 uger.
English: Following single oral dose administration (20 mg/kg) to epileptic children (6 to 12 years), the half-life of levetiracetam was 6.0 hours.
Danish: Efter indgivelse af en enkelt oral dosis (20 mg/kg) til børn (6 til12 år) med epilepsi, var halveringstiden for levetiracetam 6,0 timer.
English: This leaflet was last revised in month/YYYY.
Danish: Denne indlægsseddel blev senest ændret {MM/ÅÅÅÅ}.
English: Box of 10 or 25 vials
Danish: Pakning med 10 eller 25 hætteglas
English: • Dextrose 50 mg/ml (5%) solution for injection
Danish: • Glucose 50 mg/ml (5 %) injektionsvæske, opløsning
English: Add-on therapy for infants and children less than 4 years The safety and efficacy of levetiracetam concentrate for solution for infusion in infants and children less than 4 years have not been established.
Danish: Tillægsbehandling til spædbørn og børn under 4 år Sikkerhed og virkning af levetiracetam koncentrat til infusionsvæske, opløsning hos spædbørn og børn under 4 år er ikke fastslået.
English: Preparation and administration of Levetiracetam Hospira concentrate Dose
Danish: Fremstilling og administration af Levetiracetam Hospira koncentrat Dosis
English: One vial of Levetiracetam Hospira concentrate contains 500 mg levetiracetam (5 ml concentrate of 100 mg/ml).
Danish: Et hætteglas Levetiracetam Hospira koncentrat indeholder 500 mg levetiracetam (5 ml koncentrat af 100 mg /ml).
English: Each vial contains 19 mg of sodium.
Danish: Hvert hætteglas indeholder 19 mg natrium.
English: Efficacy of levetiracetam as monotherapy was established in a double-blind, parallel group, noninferiority comparison to carbamazepine controlled release (CR) in 576 patients 16 years of age or older with newly or recently diagnosed epilepsy.
Danish: Levetiracetams virkning som monoterapi blev påvist i et dobbeltblindt, ækvivalensstudie med parallelle grupper med carbamazepin -depottabletter (CR) hos 576 patienter over 16 år med ny eller nylig diagnosticeret epilepsi.
English: Somnolence, headache
Danish: Døsighed, hovedpine
English: Convulsion, balance disorder, dizziness, lethargy, tremor
Danish: Konvulsioner, balanceforstyrrelser, svimmelhed, letargi, tremor
English: Renal impairment The daily dose must be individualised according to renal function.
Danish: Nedsat nyrefunktion Den daglige dosis skal justeres individuelt i forhold til nyrefunktion.
English: End-stage renal disease patients undergoing dialysis
Danish: Patienter i slutstadiet af nyresygdom, som er i dialyse
English: Two embryo-foetal development (EFD) studies were performed in rats at 400, 1200 and 3600 mg/kg/day.
Danish: Der blev udført to embryo-føtale udviklingsforsøg (EFD) med 400, 1.200 og 3.600 mg/kg/dag i rotter.
English: Dose in children and adolescents 50 kg or more is the same as in adults.
Danish: Dosis til børn og unge, som vejer 50 kg eller mere, er den samme som til voksne.
English: What you need to know before you are given Levetiracetam Hospira
Danish: Det skal du vide, før du begynder at få Levetiracetam Hospira
English: • diplopia (double vision), vision blurred;
Danish: • diplopi (dobbeltsyn), sløret syn;
English: One maximum single dose of Levetiracetam Hospira concentrate contains 2.5 mmol (or 57 mg) of sodium (0.8 mmol (or 19 mg) of sodium per vial).
Danish: En maksimum enkelt dosis af Levetiracetam Hospira koncentrat indeholder 2,5 mmol (eller 57 mg) natrium (0,08 mmol (eller 19 mg) natrium per hætteglas).
English: In patients aged 1 month to less than 4 years, a total of 190 patients have been treated with levetiracetam in placebo-controlled and open label extension studies.
Danish: I alt 190 patienter, i alderen 1 måned til under 4 år, er blevet behandlet med levetiracetam i placebokontrollerede og åbne, forlængede studier.
English: Depression, hostility/aggression, anxiety, insomnia, nervousness/irritability
Danish: Depression, fjendtlighed/ aggression, angst, insomni, nervøsitet/ irritabilitet
English: Levetiracetam concentrate for solution for infusion was found to be physically compatible and chemically stable when mixed with the following diluents:
Danish: Levetiracetam koncentrat til infusionsvæske, opløsning, er fundet fysisk kompatibelt og kemisk stabilt, når det blandes med følgende fortyndingsvæsker:
English: 44.6% of the levetiracetam treated patients and 19.6% of the patients on placebo had a 50% or greater reduction from baseline in the partial onset seizure frequency per week.
Danish: 44,6 % af de patienter, som fik levetiracetam, og 19,6 % af de patienter, som fik placebo, havde 50 % eller større reduktion i frekvensen af partielle anfald pr. uge, i forhold til baseline.
English: Four embryo-foetal development studies were performed in rabbits covering doses of 200, 600, 800, 1,200 and 1,800 mg/kg/day.
Danish: Der blev udført fire embryo-føtale udviklingsforsøg med doser på 200, 600, 800, 1.200 og 1.800 mg/kg/dag i kaniner.
English: Preparation and administration of Levetiracetam Hospira concentrate for solution for infusion Dose
Danish: Forberedelse og administration af Levetiracetam Hospira koncentrat til infusionsvæske, opløsning Dosis
English: primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic generalised epilepsy (the type of epilepsy that is thought to have a genetic cause).
Danish: • primært generaliserede tonisk-kloniske anfald (større anfald med bevidstløshed) hos voksne og unge over 12 år med idiopatisk generaliseret epilepsi (den type epilepsi, som menes at være genetisk forårsaget).
English: 10 vials 25 vials
Danish: 10 hætteglas 25 hætteglas
English: Suicide attempt, suicidal ideation, psychotic disorder, abnormal behaviour, hallucination, anger, confusional state, panic attack, affect lability/mood swings, agitation
Danish: Selvmordsforsøg, selvmordstanker , psykose, unormal adfærd, hallucinationer, vrede, konfusion, panikanfald, affektlabilitet/ humørsvingninger, agitation
English: See the table below for the recommended preparation and administration of Levetiracetam Hospira concentrate for solution for infusion to achieve a total daily dose of 500 mg, 1,000 mg, 2,000 mg, or 3,000 mg in two divided doses.
Danish: Se nedenstående tabel for anbefalet forberedelse og administration af Levetiracetam Hospira koncentrat til infusionsvæske, opløsning, for at opnå en samlet daglig dosis på 500 mg, 1.000 mg, 2.000 mg eller 3.000 mg fordelt på to doser.
English: See the table below for the recommended preparation and administration of Levetiracetam Hospira concentrate to achieve a total daily dose of 500 mg, 1,000 mg, 2,000 mg, or 3,000 mg in two divided doses.
Danish: Se nedenstående tabel for den anbefalede fremstilling og administration af Levetiracetam Hospira koncentrat for at opnå en samlet daglig dosis på 500 mg, 1.000 mg, 2.000 mg eller 3.000 mg fordelt på to doser.
English: 1,500 twice daily Children 25 kg or less should preferably start the treatment with levetiracetam 100 mg/ml oral solution.
Danish: Børn på 25 kg eller derunder bør starte behandlingen med levetiracetam oral opløsning 100 mg/ml.
English: In patients aged 4-16 years, a total of 645 patients have been treated with levetiracetam in placebo-controlled and open label extension studies.
Danish: I alt 645 patienter, i alderen 4-16 år er blevet behandlet med levetiracetam i placebokontrollerede og åbne, forlængede studier.
English: Starting dose: 10 mg/kg twice daily
Danish: Startdosis: 10 mg/kg to gange dagligt
English: The NOAEL was ≥ 1800 mg/kg/day for the F0 females, and for the survival, growth and development of the F1 offspring up to weaning (x 6 the MRHD on a mg/m2 basis).
Danish: NOAEL var ≥ 1.800 mg/kg/dag for F0-hunnerne samt for overlevelse, vækst og udvikling af F1-afkom indtil ophør af diegivning (6 x MRHD på basis af mg/m
English: For adult patients, refer to the following table and adjust the dose as indicated.
Danish: Dosis hos voksne skal justeres i henhold til nedenstående tabel.
English: Levetiracetam Hospira concentrate was found to be physically compatible and chemically stable when mixed with the following diluents:
Danish: Levetiracetam koncentrat er fundet fysisk kompatibelt og kemisk stabilt i mindst 24 timer, når det blandes med følgende fortyndingsvæsker:
English: Pancytopenia, neutropenia agranulocytosis
Danish: Pancytopeni, neutropeni, agranulocytose
English: Specialist advice should be given to women who are of childbearing potential.
Danish: Der bør gives medicinsk specialistrådgivning til fertile kvinder.
English: Infusion Time Frequency of administration
Danish: Infusions tid
English: As with all antiepileptic medicines, sudden discontinuation of levetiracetam should be avoided as this may lead to breakthrough seizures that could have serious consequences for the woman and the unborn child. Monotherapy should be preferred whenever possible because therapy with multiple antiepileptic medicines AEDs could be associated with a higher risk of congenital malformations than monotherapy, depending on the associated antiepileptics.
Danish: Hvis det er muligt bør monoterapi foretrækkes, da behandling med flere antiepileptika (AED'er) kunne være forbundet med højere risiko for medfødte misdannelser end behandling med monoterapi, afhængigt af de pågældende antiepileptika.
English: • muscle weakness, myalgia (muscle pain);
Danish: • muskelsvaghed, myalgi (muskelsmerter)
English: No adverse reactions on male or female fertility or reproduction performance were observed in rats at doses up to 1,800 mg/kg/day (x 6 the MRHD on a mg/m2 or exposure basis) in parents and F1 generation.
Danish: Der blev ikke observeret bivirkninger på fertilitet eller reproduktionsevne hos han- og hunrotter ved doser på op til 1.800 mg/kg/dag (6 x MRHD på basis af mg/m2 eller eksponeringsbasis) i forældre og
English: The intravenous formulation is an alternative to your oral administration.
Danish: Den intravenøse formulering er et alternativ til at give medicinen gennem munden.
English: Dose changes can be made in 500 mg twice daily increases or decreases every two to four weeks.
Danish: Dosisændring kan gennemføres med en dosisøgning eller -reduktion på 500 mg to gange dagligt hver anden til fjerde uge.
English: • vertigo (sensation of rotation);
Danish: • svimmelhed (følelse af at snurre rundt);
English: Other ingredients include sodium acetate trihydrate, glacial acetic acid, sodium chloride, water for injections.
Danish: Andre indholdsstoffer er natriumacetattrihydrat, eddikesyre, natriumchlorid, vand til injektionsvæsker.
English: Dosing adjustment for adult and adolescents patients weighing more than 50 kg with impaired renal function:
Danish: Dosisjustering for voksne og unge patienter med nedsat nyrefunktion, som vejer mere end 50 kg: Nyrefunktion
English: • in the treatment of partial onset seizures with or without secondary generalisation in adults, adolescents and children from 4 years of age with epilepsy.
Danish: • partielle anfald med eller uden generalisering hos voksne, unge, og børn, der er over 4 år gamle
English: Amnesia, memory impairment, coordination abnormal/ataxia, paraesthesia, disturbance in attention
Danish: Amnesi, hukommelsessvækkelse, koordinationsforstyrrelser/ata ksi, paræstesi, opmærksomhedsforstyrrelser
English: Maximum dose: 30 mg/kg twice daily
Danish: Maksimaldosis: 30 mg/kg to gange dagligt
English: Levetiracetam Hospira concentrate for solution for infusion is an alternative for patients when administration of the antiepileptic levetiracetammedicine by mouth is temporarily not feasible.
Danish: Levetiracetam Hospira koncentrat til infusionsvæske, opløsning,eretalternativtilpatienter, når det midlertidigt ikke er muligt at indtage antiepileptisk levetiracetam lægemiddelgennem munden.
English: Levetiracetam Hospira 100 mg/ml sterile concentrate levetiracetam
Danish: Levetiracetam Hospira 100 mg/ml sterilt koncentrat levetiracetam i.v.
English: Neonatal and juvenile animal studies in rats and dogs demonstrated that there were no adverse effects seen in any of the standard developmental or maturation endpoints at doses up to 1,800 mg/kg/day (x 6-17 the MRHD on a mg/m2 basis)
Danish: Neonatale og juvenile dyreforsøg med rotter og hunde demonstrerede, at der med doser op til 1.800 mg/kg/dag (6-17 x MRHD på basis af mg/m2) ikke var uønskede virkninger på standardudvikling og modningsmålepunkter.
English: Choreoathetosis, dyskinesia, hyperkinesia, gait disturbance, encephalopathy
Danish: Koreoatetose, dyskinesi, hyperkinesi, gangforstyrrelse, encefalopati
English: Drug reaction with eosinophilia and systemic symptoms (DRESS).
Danish: Bivirkning med eosinofili og systemiske symptomer (DRESS) hypersensitivitet (inklusive angioødem og anafylaksi)
English: Creatinine clearance (ml/min/1.73m
Danish: Kreatininclearance (ml/min/1.73m
English: • weight decrease, weight increase;
Danish: • vægttab, vægtøgning;
English: The other ingredients are: sodium acetate trihydrate, glacial acetic acid, sodium chloride, water for injections.
Danish: - Øvrige indholdsstoffer: Natriumacetattrihydrat, eddikesyre, natriumchlorid, vand til injektionsvæsker.
English: In this study, levetiracetam, dose was 3,000 mg/day given in 2 divided doses.
Danish: I dette studie var levetiracetam-dosis 3.000 mg/dag fordelt på 2 doser.
English: Clear, colourless solution
Danish: Klar, farveløs opløsning.
English: The CLcr in ml/min may be estimated from serum creatinine (mg/dl) determination, for adults and adolescents weighting 50 kg or more, the following formula:
Danish: Hos voksne og unge, som vejer over 50 kg, kan CLcr i ml/min beregnes ud fra serum-kreatinin (mg/dl) ved at anvende følgende formel:
English: What Levetiracetam Hospira contains
Danish: Levetiracetam Hospira indeholder:
English: Add-on therapy for adults (≥18 years) and adolescents (12 to 17 years) weighing 50 kg or more The initial therapeutic dose is 500 mg twice daily.
Danish: Tillægsbehandling til voksne (≥18 år) og unge (12 til 17 år) som vejer 50 kg eller mere Den initiale terapeutiske dosis er 500 mg to gange dagligt.
English: Dose in adults and adolescents (12 to 17 years) weighing 50 kg or more: General dose: between 1,000 mg and 3,000 mg each day.
Danish: Dosis til voksne og unge (12 til 17 år), som vejer 50 kg eller mere: Den sædvanlige dosis er mellem 1.000 mg og 3.000 mg dagligt.
English: The NOAEL (No Observed Adverse Effect Level) was 3600 mg/kg/day for pregnant female rats (x 12 the MRHD on a mg/m2 basis) and
Danish: NOAEL (No Observed Adverse Effect Level) var 3.600 mg/kg/dag for drægtige hunrotter (12 x MRHD (Maximum Recommended Human Dose) på basis af mg/m2) og 1.200 mg/kg/dag for fostre.
English: Dosing adjustment for children and adolescents patients weighing less than 50 kg with impaired renal function:
Danish: Dosisjustering for børn og unge, som vejer mindre end 50 kg, med nedsat nyrefunktion: Nyrefunktion
English: Levetiracetam Hospira is not indicated in children and adolescents below 16 years on it's own (monotherapy)
Danish: • Levetiracetam Hospira som eneste lægemiddel (monoterapi) er ikke indiceret til børn og unge under 16 år.
English: Other medicines and Levetiracetam Hospira
Danish: Brug af anden medicin sammen med Levetiracetam Hospira
English: Levetiracetam Hospira contains sodium
Danish: Levetiracetam Hospira indeholder natrium
English: Add-on therapy for children aged 4 to 11 years and adolescents (12 to 17 years) weighing less than 50 kg The initial therapeutic dose is 10 mg/kg twice daily.
Danish: Tillægsbehandling til børn i alderen 4 til 11 år og unge (12 til 17 år), som vejer mindre end 50 kg Den initiale terapeutiske dosis er 10 mg/kg to gange daglig.
English: It is therefore recommended to adjust the maintenance daily dose of levetiracetam, based on creatinine clearance in patients with moderate and severe renal impairment (see section 4.2).
Danish: Hos patienter med moderat og udtalt nyrefunktionsnedsættelse anbefales det derfor at justere daglig vedligeholdelsesdosis af levetiracetam i forhold til kreatininclearance (se pkt.
English: A double-blind, placebo-controlled paediatric safety study with a non-inferiority design has assessed the cognitive and neuropsychological effects of levetiracetam in children 4 to 16 years of age with partial onset seizures.
Danish: Levetiracetams kognitive og neuropsykologiske effekt hos børn i alderen 4-16 år med partielle anfald blev vurderet i et dobbeltblindt, placebokontrolleret pædiatrisk sikkerhedsstudie med non-inferiort design.
English: The safety and efficacy of levetiracetam in children below and adolescents 16 years as monotherapy treatment have not been established.
Danish: Levetiracetams sikkerhed og virkning som monoterapi til behandling af børn og unge under 16 år er ikke klarlagt.
English: Dose in children (4 to 11 years) and adolescents (12 to 17 years) weighing less than 50 kg: General dose: between 20 mg per kg bodyweight and 60 mg per kg bodyweight each day.
Danish: Dosis til børn (4 til 11 år) og unge (12 til 17 år), som vejer under 50 kg: Den sædvanlige dosis er mellem 20 mg og 60 mg pr. kg legemsvægt dagligt.
English: 1,500 mg 15 ml (three 5 ml vials)
Danish: 1.500 mg 15 ml (tre 5 ml hætteglas)
English: lethargy (lack of energy and enthusiasm), tremor (involuntary trembling);
Danish: • kramper, problemer med at holde balancen, svimmelhed (følelse af usikker gang), letargi (mangel på energi og entusiasme), tremor (ufrivillig rysten);
English: Monotherapy for adults and adolescents from 16 years of age The recommended starting dose is 250 mg twice daily which should be increased to an initial therapeutic dose of 500 mg twice daily after two weeks.
Danish: Den anbefalede initialdosis er 250 mg to gange dagligt, som efter to uger øges til en initial terapeutisk dosis på 500 mg to gange dagligt.