FrancophonIA/ELRC3.0 huggingface dataset:
English: In non-clinical safety studies, high doses of valsartan (200 to 600 mg/kg body weight) caused in rats a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit) and evidence of changes in renal haemodynamics (slightly raised blood urea nitrogen, and renal tubular hyperplasia and basophilia in males).
Slovenian: V nekliničnih študijah varnosti so visoki odmerki valsartana (200 do 600 mg/kg telesne mase) pri podganah povzročili zmanjšanje parametrov rdečih krvnih celic (ertirocitov, hemoglobina, hematokrita) in znake spremenjene ledvične hemodinamike (nekoliko zvišana vrednost dušika sečnine v krvi in hiperplazija ledvičnih tubulov ter bazofilija pri samcih).
English: Correction of this condition prior to administration of Dafiro or close medical supervision at the start of treatment is recommended.
Slovenian: Priporočljivo je, da pred začetkom uporabe zdravila Dafiro, popravite to stanje ali bolniku zagotovite natančen zdravniški nadzor na začetku zdravljenja.
English: if you have severe liver problems or bile problems such as biliary cirrhosis or cholestasis.
Slovenian: če imate hude težave z jetri ali z žolčem, npr. biliarno cirozo ali holestazo.
English: Cellulose microcrystalline Crospovidone (type A) Silica, colloidal anhydrous Magnesium stearate
Slovenian: Jedro tablete mikrokristalna celuloza krospovidon (tipa A) brezvoden koloidni silicijev dioksid magnezijev stearat
English: Consult a doctor immediately if you experience any of the following very rare, severe side effects after taking this medicine: - Sudden wheeziness, chest pain, shortness of breath or difficulty in breathing.
Slovenian: Če med jemanjem zdravila opazite kateregakoli od spodaj naštetih, zelo redkih, hudih neželenih učinkov, se nemudoma posvetujte z zdravnikom: - nenadna zasoplost, bolečine v prsih, kratka sapa ali težave z dihanjem.
English: In patients with severe heart failure whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with ACE inhibitors and angiotensin receptor antagonists has been associated with oliguria and/or progressive azotaemia and (rarely) with acute renal failure and/or death.
Slovenian: Pri bolnikih s hudim srčnim popuščanjem, pri katerih je delovanje ledvic lahko odvisno od aktivnosti sistema renin-angiotenzin-aldosteron, so se med zdravljenjem z zaviralci ACE in antagonisti angiotenzinskih receptorjev pojavile oligurija in/ali napredujoča azotemija ter (redko) akutna odpoved ledvic in/ali smrt.
English: ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE inhibitor or an ARB in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both.
Slovenian: Študija ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) je preučevala koristi dodatka aliskirena standardnemu zdravljenju z zaviralcem ACE ali antagonistom angiotenzinskih receptorjev pri bolnikih s sladkorno boleznijo tipa 2 in kronično boleznijo ledvic, kardiovaskularno boleznijo ali obojim.
English: The half life of amlodipine is prolonged and AUC values are higher in patients with impaired liver function; dosage recommendations have not been established.
Slovenian: Pri bolnikih z okvaro jeter je razpolovni čas amlodipina podaljšan, vrednosti AUC pa so višje; priporočila za prilagoditev odmerkov niso bila izoblikovana.
English: In a clinical trial of patients with a history of dry cough during ACE inhibitor therapy, 19.5% of trial subjects receiving valsartan and 19.0% of those receiving a thiazide diuretic experienced coughing, compared to 68.5% of those treated with an ACE inhibitor (p <0.05).
Slovenian: V kliničnem preskušanju pri bolnikih z anamnezo suhega kašlja med terapijo z zaviralcem ACE se je kašelj pojavil pri 19,5 % preiskovancev, ki so dobivali valsartan, 19,0 % tistih, ki so prejemali tiazidni diuretik, in 68,5 % preiskovancev, ki so dobivali zaviralec ACE (p <0,05).
English: The patients had at least one additional coronary heart disease risk factor, including: previous myocardial infarction or stroke (>6 months prior to enrollment) or documentation of other atherosclerotic cardiovascular disease (overall 51.5%), type 2 diabetes (36.1%), high density lipoprotein - cholesterol <35 mg/dl or <0.906 mmol/l (11.6%), left ventricular hypertrophy diagnosed by electrocardiogram or echocardiography (20.9%), current cigarette smoking (21.9%).
Slovenian: Bolniki so imeli poleg hipertenzije še najmanj en dejavnik tveganja za koronarno bolezen, in sicer so že preboleli miokardni infarkt ali možgansko kap (>6 mesecev pred vključitvijo v študijo) ali pa so imeli dokumentirano drugo aterosklerotično kardiovaskularno bolezen (skupaj 51,5 %), sladkorno bolezen tipa 2 (36,1 %), vrednost holesterola lipoproteinov visoke gostote <35 mg/dl ali <0,906 mmol/l (11,6 %), elektrokardiografsko ali ehokardiografsko ugotovljeno hipertrofijo levega prekata (20,9 %) ali pa so v času študije kadili (21,9 %).
English: Clinically significant hypotension due to Dafiro overdose calls for active cardiovascular support, including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulating fluid volume and urine output.
Slovenian: Klinično značilna hipotenzija zaradi prevelikega odmerka zdravila Dafiro zahteva srčnožilno podporo, vključno s pogostim nadziranjem delovanja srca in dihal, dviganjem udov ter kontrolo krožečega volumna tekočine in izločanja urina.
English: There is evidence that the concomitant use of ACE inhibitors, ARBs or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure).
Slovenian: Obstajajo dokazi, da sočasna uporaba zaviralcev ACE, antagonistov angiotenzinskih receptorjev ali aliskirena poveča tveganje za hipotenzijo, hiperkaliemijo in zmanjšano delovanje ledvic (vključno z akutno odpovedjo ledvic).
English: If you forget to take Dafiro
Slovenian: Če ste pozabili vzeti zdravilo Dafiro
English: VA NEPHROND was a study in patients with type 2 diabetes mellitus and diabetic nephropathy.
Slovenian: Študija VA NEPHRON-D je zajela bolnike s sladkorno boleznijo tipa 2 in diabetično nefropatijo.
English: If you experience any of these, tell your doctor straight away.
Slovenian: Če se vam pojavi karkoli od naštetega, morate to takoj povedati zdravniku.
English: PVC/PVDC perforated unit dose blisters.
Slovenian: PVC/PVDC perforirani pretisni omoti za enkratni odmerek.
English: - Severe skin reactions including intense skin rash, hives, reddening of the skin over your whole body, severe itching, blistering, peeling and swelling of the skin, inflammation of the mucous membranes (Stevens-Johnson Syndrome, toxic epidermal necrolysis) or other allergic reactions.
Slovenian: - hude kožne reakcije, vključno s hudim kožnim izpuščajem, koprivnico, pordelostjo kože po celem telesu, močnim srbenjem, pojavljanjem mehurjev, lupljenjem in otekanjem kože, vnetjem sluzničnih membran (Stevens-Johnsonov sindrom, toksična epidermalna nekroliza) in drugimi alergijskimi reakcijami.
English: • Hypersensitivity to the active substances, to dihydropyridine derivatives, or to any of the excipients listed in section 6.1.
Slovenian: • Preobčutljivost na učinkovini, na dihidropiridinske derivate ali katero koli pomožno snov,
English: If you get these symptoms, stop taking Dafiro and contact your doctor straight away.
Slovenian: Če opazite navedene simptome, takoj prenehajte jemati zdravilo Dafiro in obvestite svojega zdravnika.
English: Other: dual blockade of the renin-angiotensin-aldosterone system (RAAS) Two large randomised, controlled trials (ONTARGET [ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial] and VA NEPHRON-D [The Veterans Affairs Nephropathy in Diabetes]) have examined the use of the combination of an ACE inhibitor with an ARB.
Slovenian: Drugo: Dvojno zaviranje sistema renin-angiotenzin-aldosteron (RAAS) Uporabo zaviralca ACE v kombinaciji z antagonistom angiotenzinskih receptorjev so raziskali v dveh velikih randomiziranih, kontroliranih preskušanjih: ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) in VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes).
English: The mean incidence of peripheral oedema evenly weighted across all doses was 5.1% with the amlodipine/valsartan combination.
Slovenian: Povprečna incidenca perifernih edemov, enakovredno uravnotežena za vse odmerke kombinacije amlodipin/valsartan, je bila 5,1 %.
English: Side effects reported with amlodipine or valsartan alone and either not observed with Dafiro or observed with a higher frequency than with Dafiro:
Slovenian: Neželeni učinki, o katerih so poročali pri uporabi amlodipina ali valsartana samega, ki jih bodisi niso opažali pri uporabi zdravila Dafiro ali pa so jih opažali z večjo pogostnostjo kot pri uporabi zdravila Dafiro:
English: Pack sizes: 7, 14, 28, 30, 56, 90, 98 or 280 film-coated tablets and multipacks containing 280 (4x70 or 20x14) film-coated tablets.
Slovenian: Velikosti pakiranj: 7, 14, 28, 30, 56, 90, 98 ali 280 filmsko obloženih tablet in skupna pakiranja, ki vsebujejo 280 (4x70 ali 20x14) filmsko obloženih tablet.
English: In monotherapy with valsartan, no interactions of clinical significance have been found with the following substances: cimetidine, warfarin, furosemide, digoxin, atenolol, indometacin, hydrochlorothiazide, amlodipine, glibenclamide.
Slovenian: Med monoterapijo z valsartanom niso ugotovili klinično pomembnih interakcij z naslednjimi učinkovinami: cimetidinom, varfarinom, furosemidom, digoksinom, atenololom, indometacinom, hidroklorotiazidom, amlodipinom, glibenklamidom.
English: There are no clinical studies on fertility with Dafiro.
Slovenian: Kliničnih študij glede plodnosti pri uporabi zdravila Dafiro ni.
English: This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active substance amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of Dafiro.
Slovenian: Grenivka in grenivkin sok lahko namreč povzročita zvišanje koncentracije zdravilne učinkovine amlodipina v krvi, kar lahko pripelje do nepredvidljivega povečanja učinka zdravila Dafiro pri zniževanju krvnega tlaka.
English: Valsartan has been studied in patients with post myocardial infarction and heart failure.
Slovenian: Valsartan je raziskan pri bolnikih po miokardnem infarktu in s srčnim popuščanjem.
English: If you stop taking Dafiro
Slovenian: Če ste prenehali jemati zdravilo Dafiro
English: All packs are available with standard blisters; the 56, 98 and 280 tablet packs are additionally available with perforated unit dose blisters.
Slovenian: V vseh pakiranjih so tablete na voljo v standardnih pretisnih omotih, v pakiranjih po 56, 98 in 280 tablet pa so poleg tega na voljo tudi v perforiranih pretisnih omotih z razdelki za enkratni odmerek.
English: When clinically appropriate, direct change from monotherapy to the fixed-dose combination may be considered.
Slovenian: Če je klinično primerno, je možno na kombinacijo s fiksnim odmerkom preiti neposredno z monoterapije.
English: Since there is no effect on ACE and no potentiation of bradykinin or substance P, angiotensin II antagonists are unlikely to be associated with coughing.
Slovenian: Ker antagonisti angiotenzina II ne vplivajo na ACE in ne potencirajo delovanja bradikinina ali snovi P, ni verjetno, da bi jih spremljal kašelj.
English: Summary of the safety profile
Slovenian: Povzetek varnostnih lastnosti zdravila
English: Among secondary endpoints, the incidence of heart failure (component of a composite combined cardiovascular endpoint) was significantly higher in the amlodipine group as compared to the chlorthalidone group (10.2% versus 7.7%, RR 1.38, 95% CI [1.25-1.52] p<0.001).
Slovenian: Med sekundarnimi cilji opazovanja je bila pogostnost srčnega popuščanja (eden od izidov, ki so bili vključeni v sestavljen kardiovaskularni cilj opazovanja) statistično značilno večja v skupini z amlodipinom v primerjavi s skupino s klortalidonom (10,2 % v primerjavi s 7,7 %, z razmerjem tveganj (RR) 1,38; 95-odstotnim IZ 1,25-1,52 in vrednostjo p <0,001).
English: Heart failure/post-myocardial infarction
Slovenian: Srčno popuščanje/obdobje po miokardnem infarktu
English: * Mostly consistent with cholestasis
Slovenian: * o tem so najpogosteje poročali v povezavi s holestazo
English: A randomised double-blind morbidity-mortality study called the Antihypertensive and LipidLowering treatment to prevent Heart Attack Trial (ALLHAT) was performed to compare newer therapies: amlodipine 2.5-10 mg/day (calcium channel blocker) or lisinopril 10-40 mg/day (ACEinhibitor) as first-line therapies to that of the thiazide-diuretic, chlorthalidone 12.5-25 mg/day in mild to moderate hypertension.
Slovenian: Randomizirano, dvojno slepo študijo obolevnosti in umrljivosti z nazivom Študija antihipertenzivnega zdravljenja in zniževanja vrednosti lipidov za preprečevanje srčnega infarkta (Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial - ALLHAT) so izvajali zato, da bi ocenili novejše načine zdravljenja: amlodipin 2,5-10 mg/dan (zaviralec kalcijevih kanalčkov) ali lizinopril 10-40 mg/dan (zaviralec ACE) kot zdravili prvega izbora v primerjavi s tiazidnim diuretikom klortalidonom 12,5-25 mg/dan pri blagi do zmerni hipertenziji.
English: Over 1,400 hypertensive patients received Dafiro once daily in two placebo-controlled trials.
Slovenian: V dveh s placebom kontroliranih preskušanjih je zdravilo Dafiro enkrat na dan dobivalo več kot 1.400 bolnikov s hipertenzijo.
English: Particular caution should be exercised when administering Dafiro to patients with mild to moderate hepatic impairment or biliary obstructive disorders.
Slovenian: Posebna previdnost je potrebna v primeru uporabe zdravila Dafiro pri bolnikih z blago do zmerno okvaro jeter ali z obstruktivnimi biliarnimi boleznimi.
English: Caution should be exercised when administering Dafiro to patients with hepatic impairment or biliary obstructive disorders (see section 4.4).
Slovenian: Previdnost je potrebna pri uporabi zdravila Dafiro pri bolnikih z okvaro jeter ali obstruktivno biliarno boleznijo (glejte poglavje 4.4).
English: Amlodipine is excreted in human milk .
Slovenian: Amlodipin se izloča v materino mleko.
English: Adverse reactions previously reported with one of the individual components (amlodipine or valsartan) may be potential adverse reactions with Dafiro as well, even if not observed in clinical trials or during the post-marketing period.
Slovenian: Dodatne informacije o posameznih zdravilnih učinkovinah Neželeni učinki, opisani za katero od obeh zdravilnih učinkovin (za amlodipin ali valsartan), so lahko tudi neželeni učinki zdravila Dafiro, tudi če niso bili ugotovljeni v kliničnih preskušanjih ali v obdobju po prihodu zdravila na trg.
English: Frequency Dafiro Amlodipine Valsartan
Slovenian: Pogostnost Dafiro Amlodipin Valsartan
English: Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (heparin, etc.) should be undertaken with caution and with frequent monitoring of potassium levels.
Slovenian: Med sočasno uporabo dodatkov kalija, diuretikov, ki varčujejo s kalijem, nadomestkov soli, ki vsebujejo kalij, ali drugih zdravil, ki lahko povečajo koncentracijo kalija (npr. heparin), je potrebna previdnost; v takšnih primerih je potrebno pogosto nadziranje koncentracije kalija.
English: If any of these apply to you, tell your doctor before taking Dafiro.
Slovenian: Če kaj od naštetega velja za vas, morate to povedati zdravniku, preden vzamete zdravilo Dafiro.
English: In clinical studies in which amlodipine was administered in combination with beta blockers to patients with either hypertension or angina, no adverse effects on electrocardiographic parameters were observed.
Slovenian: V kliničnih študijah, v katerih so pri bolnikih s hipertenzijo ali angino pektoris amlodipin uporabili v kombinaciji z zaviralci beta, niso zabeležili neželenih vplivov na elektrokardiografske parametre.
English: Patients with high cardiovascular risks - heart failure, type I and poorly controlled type II diabetes and history of myocardial infarction or stroke within one yearwere excluded.
Slovenian: Izključeni so bili bolniki z velikim srčnožilnim tveganjem - s srčnim popuščanjem, z diabetesom tipa 1 ali s slabo urejenim diabetesom tipa 2 ali z miokardnim infarktom, ali možgansko kapjo v zadnjem letu.
English: Both valsartan and amlodipine are unlikely to be removed by haemodialysis.
Slovenian: Ni verjetno, da bi valsartan in amlodipin odstranili z dializo.
English: Grapefruit or grapefruit juice
Slovenian: Grenivka ali grenivkin sok
English: In this study (baseline blood pressure 171/113 mmHg), a Dafiro regimen of 5 mg/160 mg titrated to 10 mg/160 mg reduced sitting blood pressure by 36/29 mmHg as compared to 32/28 mmHg with a regimen of lisinopril/hydrochlorothiazide 10 mg/12.5 mg titrated to 20 mg/12.5 mg.
Slovenian: V tej študiji (izhodiščni krvni tlak 171/113 mm Hg) je shema odmerjanja zdravila Dafiro 5 mg/160 mg, titrirana do 10 mg/160 mg, znižala krvni tlak sede za 36/29 mm Hg; v primerjavi s tem je shema odmerjanja lizinoprila/hidroklorotiazida 10 mg/12,5 mg, titrirana do 20 mg/12,5 mg, znižala krvni tlak za 32/28 mm Hg.
English: Excessive hypotension was seen in 0.4% of patients with uncomplicated hypertension treated with Dafiro in placebo-controlled studies.
Slovenian: V študijah, kontroliranih s placebom, so čezmerno hipotenzijo opažali pri 0,4 % bolnikov z nezapleteno hipertenzijo, ki so dobivali zdravilo Dafiro.
English: This means that both of these substances help to stop the blood vessels tightening.
Slovenian: To pomeni, da obe učinkovini v tem zdravilu pomagata preprečiti zožitev žil.
English: Dual blockade of the RAAS with ARBs, ACE inhibitors or aliskiren Clinical trial data have shown that dual blockade of the RAAS through the combined use of ACE inhibitors, ARBs or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4 and 5.1).
Slovenian: Podatki kliničnih preskušanj so pokazali, da je dvojna blokada sistema renin-angiotenzin-aldosteron (RAAS) s hkratno uporabo zaviralcev ACE, antagonistov angiotenzinskih receptorjev ali aliskirena povezana z večjo pogostnostjo neželenih učinkov, npr. hipotenzije, hiperkaliemije in zmanjšanega delovanja ledvic (vključno z akutno odpovedjo ledvic) kot uporaba enega samega zdravila, ki deluje na RAAS (glejte poglavja 4.3, 4.4. in 5.1).
English: Talk to your doctor before taking Dafiro: if you have been sick (vomiting or diarrhoea).
Slovenian: Opozorila in previdnostni ukrepi Pred začetkom jemanja zdravila Dafiro se posvetujte z zdravnikom: če vam je bilo slabo (bruhanje ali driska).
English: Dafiro is not recommended for mothers who are breastfeeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Slovenian: Če želite dojiti, bo zdravnik za vas izbral drugo zdravilo, še posebno če je vaš otrok še novorojenček ali je bil rojen prezgodaj.
English: There was no significant difference in the primary endpoint between amlodipine-based therapy and chlorthalidone-based therapy: risk ratio (RR) 0.98 95% CI (0.90-1.07) p=0.65.
Slovenian: Pri primarnem cilju opazovanja ni bilo statistično značilne razlike med zdravljenjem, ki je vključevalo amlodipin, in tistim, ki je vključevalo klortalidon: razmerje tveganj (risk ratio - RR) je bilo 0,98; 95-odstotni IZ: 0,90-1,07 in vrednost p=0,65.
English: For the single compounds there was no evidence of mutagenicity, clastogenicity or carcinogenicity.
Slovenian: Za posamezni učinkovini niso ugotovili, da bi bili mutageni, klastogeni ali kancerogeni.
English: There is no experience of overdose with Dafiro.
Slovenian: Izkušenj s prevelikim odmerjanjem zdravila Dafiro ni.
English: 7 film-coated tablets 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 56 film-coated tablets 90 film-coated tablets 98 film-coated tablets 280 film-coated tablets 56x1 film-coated tablet (unit dose) 98x1 film-coated tablet (unit dose) 280x1 film-coated tablet (unit dose)
Slovenian: 14 filmsko obloženih tablet 28 filmsko obloženih tablet 30 filmsko obloženih tablet 56 filmsko obloženih tablet 90 filmsko obloženih tablet 98 filmsko obloženih tablet 280 filmsko obloženih tablet 56x1 filmsko obložena tableta (za enkratni odmerek) 98x1 filmsko obložena tableta (za enkratni odmerek) 280x1 filmsko obložena tableta (za enkratni odmerek)
English: Dafiro tablets contain two substances called amlodipine and valsartan.
Slovenian: Tablete zdravila Dafiro vsebujejo dve učinkovini: amlodipin in valsartan.
English: Therefore, careful monitoring of serum lithium levels is recommended during concomitant use.
Slovenian: Med sočasno uporabo je zato priporočljivo natančno kontrolirati koncentracijo litija v serumu.
English: Following oral administration of Dafiro, peak plasma concentrations of valsartan and amlodipine are reached in 3 and 6-8 hours, respectively.
Slovenian: Po peroralni uporabi zdravila Dafiro doseže valsartan največjo koncentracijo v plazmi v 3 urah, amlodipin pa v 6 do 8 urah.
English: Exposure to AIIRA therapy during the second and third trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see section 5.3).
Slovenian: Znano je, da izpostavljenost antagonistom angiotenzina II v drugem in tretjem trimesečju nosečnosti lahko povzroči fetotoksične učinke pri človeku (zmanjšano delovanje ledvic, oligohidramnij, zapoznela zakostenitev lobanje) in toksične učinke pri novorojenčku (ledvična odpoved, hipotenzija, hiperkaliemija) (glejte poglavje 5.3).
English: Dilated ureters were also found in the valsartan alone group (exposure 12 times the clinical dose of 160 mg valsartan).
Slovenian: Razširjene ureterje so ugotovili tudi v skupini, ki je dobivala samo valsartan (12-krat večja izpostavljenost kot ob kliničnem odmerku 160 mg valsartana).
English: ACE inhibitors or aliskiren (see also information under the headings “Do not take Dafiro” and “Warnings and precautions”); diuretics (a type of medicine also called “water tablets” which increases the amount of urine you produce); lithium (a medicine used to treat some types of depression); potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels; certain types of painkillers called non-steroidal anti-inflammatory medicines (NSAIDs) or selective cyclooxygenase-2 inhibitors (COX-2 inhibitors).
Slovenian: To še posebej velja za naslednja zdravila: zaviralci ACE ali aliskiren (glejte tudi informacije pod naslovoma “Ne jemljite zdravila Dafiro” in “Opozorila in previdnostni ukrepi”); diuretike (vrsto zdravil, ki jim pravimo tudi "tablete za odvajanje vode" in povečajo nastajanje urina v telesu); litij (zdravilo, ki se uporablja za zdravljenje nekaterih vrst depresij); diuretike, ki varčujejo s kalijem, kalijeve dodatke, nadomestke soli, ki vsebujejo kalij, in druge učinkovine, ki lahko zvišajo koncentracijo kalija; določena zdravila proti bolečinam, ki jih imenujemo nesteroidna protivnetna zdravila (NSAID) ali selektivni zaviralci ciklooksigenaze-2 (zaviralci COX-2).
English: Caution required with concomitant use
Slovenian: Med sočasno uporabo je potrebna previdnost