FrancophonIA/ELRC3.0 huggingface dataset:
English: Three field trials were also performed to assess the effect on mortality and clinical signs of oedema disease in a total of 518 piglets receiving Ecoporc Shiga compared with a similar number of piglets receiving placebo (a dummy injection).
Slovenian: Izvedene so bile tudi tri terenske študije, s katerimi so želeli oceniti učinek zdravila Ecoporc Shiga na zmanjšanje smrtnosti in kliničnih znakov edemske bolezni pri 518 prašičkih v primerjavi s placebom (zdravilom brez zdravilne učinkovine), ki so ga dajali podobnemu številu prašičkov.
English: The withdrawal period for Ecoporc Shiga is zero days.
Slovenian: Obdobje karence za zdravilo Ecoporc Shiga je nič dni.
English: What is the risk associated with Ecoporc Shiga?
Slovenian: Kakšna tveganja so povezana z zdravilom Ecoporc Shiga?
English: Why has Ecoporc Shiga been approved?
Slovenian: Zakaj je bilo zdravilo Ecoporc Shiga odobreno?
English: What is Ecoporc Shiga?
Slovenian: Kaj je zdravilo Ecoporc Shiga?
English: What is Ecoporc Shiga used for?
Slovenian: Za kaj se zdravilo Ecoporc Shiga uporablja?
English: How has Ecoporc Shiga been studied?
Slovenian: Kako je bilo zdravilo Ecoporc Shiga raziskano?
English: How does Ecoporc Shiga work?
Slovenian: Kako zdravilo Ecoporc Shiga deluje?
English: PC: {number} SN: {number} < NN: {number} >
Slovenian: PC: {številka} SN: {številka} <NN: {številka}>
English: They are packed in bottles.
Slovenian: Pakirane so v stekleničke.
English: Date of first authorisation: 18 August 2011 Date of latest renewal: 8 April 2016
Slovenian: Datum prve odobritve: 18. avgust 2011 Datum zadnjega podaljšanja: 8. april 2016
English: • uncontrollable excessive shopping or spending;
Slovenian: • neobvladljivo prekomerno nakupovanje ali zapravljanje;
English: wait at least 2 to 3 hours before taking the other.
Slovenian: Po zaužitju enega od teh zdravil počakajte vsaj 2 do 3 ure, preden vzamete drugo.
English: • if you have ever had a heart attack or any other diseases of the heart;
Slovenian: • če ste že kdajkoli imeli srčni napad ali katero od drugih srčnih bolezni srca;
English: vivid dreams, and confusion;
Slovenian: žive sanje in zmedenost;
English: In particular please tell your doctor if you are taking any of the following:
Slovenian: Še zlasti povejte zdravniku, če jemljete katero od naslednjih zdravil:
English: To open the bottle for the first time: open the closure, and then press with your thumb on the seal until it breaks.
Slovenian: Prvo odprtje stekleničke: Odstranite pokrovček, nato s palcem pritiskajte na pečat, dokler ne poči.
English: • Inability to resist the impulse to perform an action that could be harmful, which may include:
Slovenian: • nezmožnost upiranja nagibom za izvajanje dejavnosti, ki so lahko škodljive in lahko vključujejo:
English: Do not use this medicine after the expiry date which is stated on the carton and on the bottle label.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in nalepki stekleničke.
English: EU/1/11/708/001 30 film-coated tablets EU/1/11/708/002 60 film-coated tablets EU/1/11/708/003 100 film-coated tablets EU/1/11/708/004 175 film-coated tablets
Slovenian: EU/1/11/708/001 30 filmsko obloženih tablet EU/1/11/708/002 60 filmsko obloženih tablet EU/1/11/708/003 100 filmsko obloženih tablet EU/1/11/708/004 175 filmsko obloženih tablet
English: See Section 2 Warnings and precautions.
Slovenian: Glejte Poglavje 2 Opozorila in previdnostni ukrepi.
English: [carton only]:
Slovenian: [samo na škatli]:
English: The pharmacokinetic properties of entacapone are similar in both young people and elderly.
Slovenian: Farmakokinetične lastnosti entakapona so podobne tako pri mlajših kot pri starejših.
English: In doses of 1,400 to 2,000 mg per day, the following side effects are more common:
Slovenian: Pri odmerkih 1.400 do 2.000 mg na dan so bolj pogosti naslednji neželeni učinki:
English: Approximately 92 % of the dose is eliminated during ß-phase with a short elimination half-life of 30 minutes.
Slovenian: Približno 92 % odmerka se odstrani iz telesa v fazi ß s kratkim razpolovnim časom odstranjevanja iz telesa 30 minut.
English: 10-20% is excreted in urine.
Slovenian: Približno 10-20 % odmerka se izloča z urinom.
English: However, in an interaction study with healthy volunteers, entacapone did not change the plasma levels of S-warfarin, while the AUC for R-warfarin increased on average by 18% [CI90 11-26%].
Slovenian: Vendar v študiji medsebojnega delovanja na zdravih prostovoljcih entakapon ni spremenil plazemskih koncentracij S-varfarina, medtem ko se je AUC za R-varfarin povečala povprečno za 18 % [IZ90 11-26 %].
English: Weight decrease * Adverse reactions are ranked under headings of frequency, the most frequent first, using the following convention: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data, since no valid estimate can be derived from clinical trials or epidemiological studies).
Slovenian: Uporabljen je naslednji dogovor: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000), pogostnost neznana (ni mogoče oceniti iz razpoložljivih podatkov, ker na podlagi kliničnih preskušanj ali epidemioloških študij ni mogoče ugotoviti zanesljivih ocen pogostnosti).
English: It is estimated that 8090% of the dose is excreted in faeces, although this has not been confirmed in man.
Slovenian: Ocenjeno je, da se 80-90 % odmerka izloči z blatom, čeprav to pri človeku ni potrjeno.
English: • if you are taking certain antidepressants (ask your doctor or pharmacist whether your antidepressive medicine can be taken together with Entacapone Orion);
Slovenian: • če jemljete določene antidepresive (povprašajte svojega zdravnika ali farmacevta, ali lahko jemljete svoje zdravilo proti depresiji skupaj z zdravilom Entacapone Orion);
English: If this happens, you should not drive or use any tools or machines (see Driving and using machines).
Slovenian: Če se vam to dogaja, ne smete voziti ali uporabljati naprav ali strojev (glejte “Vpliv na sposobnost upravljanja vozil in strojev”).
English: There are four different pack sizes (bottles containing 30, 60, 100 or 175 tablets).
Slovenian: Na voljo so štiri različne velikosti pakiranj (stekleničke s 30, 60, 100 ali 175 tabletami).
English: • hallucinations (seeing/hearing/feeling/smelling things that are not really there), sleeplessness,
Slovenian: • halucinacije (pri halucinacijah bolnik vidi/sliši/čuti/voha stvari, ki jih v resnici ni), nespečnost,
English: Be particularly careful when you drive or when you use tools or machinery.
Slovenian: Bodite še posebno previdni, kadar vozite, uporabljate naprave ali upravljate stroje.
English: • warfarin used to thin the blood;
Slovenian: • varfarin proti strjevanju krvi;
English: • strong impulse to gamble excessively despite serious personal or family consequences;
Slovenian: • močno željo po pretiranem igranju iger na srečo kljub resnim posledicam, ki jih ima to lahko za bolnika osebno ali za njegovo družino;
English: Absorption There are large intra- and interindividual variations in the absorption of entacapone.
Slovenian: V absorpciji entakapona so velike intra- in interindividualne variacije.
English: Therefore, do not take Entacapone Orion and iron supplements at the same time.
Slovenian: Zato ne jemljite zdravila Entacapone Orion in dodatkov železa istočasno.
English: The (Z)-isomer and traces of other metabolites account for the remaining 5%.
Slovenian: Izomera (Z) in drugi presnovki v sledovih predstavljajo preostalih 5 %.
English: • if you are allergic to entacapone or to peanut or soya or any of the other ingredients of this medicine (listed in section 6);
Slovenian: • če ste alergični na entakapon, arašide ali sojo ali katero koli sestavino tega zdravila (navedeno v poglavju 6);
English: • iron supplements.
Slovenian: • nadomestke železa.
English: • if you experience increasing loss of appetite, weakness, exhaustion and weight loss within a relatively short period of time, a general medical evaluation including liver function should be considered.
Slovenian: • če vedno bolj izgubljate apetit, če pride do oslabelosti, izčrpanosti in izgube telesne mase v razmeroma kratkem obdobju, je treba razmisliti o splošnem zdravniškem pregledu, vključno z oceno jetrne funkcije.
English: For further information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
Slovenian: Za vse morebitne nadaljnje informacije o tem zdravilu se lahko obrnete na predstavništvo imetnika dovoljenja za promet z zdravilom:
English: Entacapone showed little or no inhibition of other types of P450 isoenzymes (CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP3A and CYP2C19) (see section
Slovenian: Entakapon je le malo oziroma sploh ni zaviral drugih vrst izoencimov P450 (CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP3A in CYP2C19) (glejte poglavje 4.5).
English: soya lecithin.
Slovenian: sojin lecitin.
English: Patients who are hypersensitive to peanut or soya, should not use this medicinal product.
Slovenian: Bolniki, ki so preobčutljivi za arašide ali sojo, ne smejo uporabljati tega zdravila.
English: • harmless reddish-brown discolouration of urine.
Slovenian: • neškodljivo rdečkastorjavo obarvanje urina.
English: Marketing Authorisation Holder and Manufacturer: Orion Corporation
Slovenian: Imetnik dovoljenja za promet z zdravilom in izdelovalec: Orion Corporation
English: Pharmacotherapeutic group: other dopaminergic agents, ATC code: N04BX02.
Slovenian: Farmakoterapevtska skupina: drugi dopaminergiki, oznaka ATC: N04BX02
English: Clinical interaction studies with diazepam and nonsteroidal anti-inflammatory medicinal products have not been carried out.
Slovenian: Klinične študije medsebojnega delovanja z diazepamom in nesteroidnimi protivnetnimi zdravili niso opravljene.
English: If you are allergic to peanut or soya, do not use this medicine.
Slovenian: Če ste alergični na arašide ali sojo, tega zdravila ne smete uporabljati.
English: • rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa,
Slovenian: • rimiterol, izoprenalin, adrenalin, noradrenalin, dopamin, dobutamin, alfa-metildopo,
English: - The film-coating contains partly hydrolysed polyvinyl alcohol, talc, macrogol, soya lecithin,
Slovenian: - Filmska obloga vsebuje delno hidrolizirani polivinil alkohol, smukec, makrogol, sojin lecitin,
English: Data from in vitro studies using human liver microsomal preparations indicate that entacapone inhibits cytochrome P450 2C9 (IC50 4 µM).
Slovenian: Podatki iz študij in vitro na preparatih mikrosomov človeških jeter kažejo, da entakapon zavira citokrom P450 2C9 (IC50 4 µM).
English: You may also use other medicines to treat Parkinson's disease at the same time.
Slovenian: Sočasno lahko jemljete tudi druga zdravila za Parkinsonovo bolezen.
English: • a rare severe muscle disorder (rhabdomyolysis) which causes pain, tenderness and weakness of the muscles and may lead to kidney problems.
Slovenian: • redka huda bolezen mišic (rabdomioliza), ki povzroča bolečine, občutljivost in šibkost mišic in lahko povzroči težave z ledvicami.
English: For the characteristics of NMS see Section 4 Possible side effects.
Slovenian: Za značilnosti NMS glejte poglavje 4 Možni neželeni učinki.
English: CI95% 45 min, 1 h 56 min Study II: Proportion of daily On time (%) Entacapone (n=103) Placebo (n=102)
Slovenian: IZ95 % 45 min, 1h 56 min Študija II: Delež dnevnega obdobja ‘ON' (%) entakapon (n=103)
English: • altered or increased sexual interest and behaviour of significant concern to you or to others,
Slovenian: • spremenjeno ali povečano zanimanje za spolnost in zaskrbljujoče spolno vedenje, na primer povečano spolno slo;
English: • abnormal results in liver function test.
Slovenian: • nenormalni izvidi testov jetrne funkcije.
English: 30 tablets 60 tablets 100 tablets 175 tablets
Slovenian: 30 tablet 60 tablet 100 tablet 175 tablet
English: If you experience such effects at the start of treatment with Entacapone Orion you should contact your doctor who may decide to adjust your dosage of levodopa.
Slovenian: Če pri vas pride od takih učinkov na začetku zdravljenja z zdravilom Entacapone Orion, morate obvestiti zdravnika, ki se bo morda odločil, da vam prilagodi odmerjanje levodope.
English: ** The incidence rates of myocardial infarction and other ischaemic heart disease events (0.43% and 1.54%, respectively) are derived from an analysis of 13 double-blind studies involving 2,082 patients with end-of-dose motor fluctuations receiving entacapone.
Slovenian: ** Pogostnost miokardnega infarkta (0,43 %) in drugih dogodkov v zvezi z ishemično boleznijo srca (1,54 %) temelji na rezultatih analize podatkov iz 13 dvojno slepih študij, v katere je bilo vključenih 2.082 bolnikov, ki so imeli motorična nihanja ob koncu delovanja odmerka in so prejemali entakapon.
English: Hepatitis with mainly cholestatic features (see section 4.4.)
Slovenian: hepatitis s prevladujočimi znaki holestaze (glejte poglavje 4.4)
English: Hepatic impairment See section 4.3.
Slovenian: Okvara jeter Glejte poglavje 4.3.
English: Uncommon (may affect up to 1 in 100 people): • Heart attack.
Slovenian: Občasni (lahko se pojavijo pri največ 1 od 100 bolnikov): • srčni napad.
English: Baseline Week 8-24 66.8±14.5
Slovenian: razlika izhodišče teden 8-24 66,8 ± 14,5
English: Dyskinesias (27%), nausea (11%), diarrhoea (8%), abdominal pain (7%) and dry mouth (4.2%) were reported significantly more often with entacapone than with placebo in pooled data from clinical studies involving 406 patients taking the medicinal product and 296 patients taking placebo.
Slovenian: Pri jemanju entakapona so bistveno pogosteje poročali o diskinezijah (27 %), navzeji (11 %), diareji (8 %), bolečinah v trebuhu (7 %) in suhih ustih (4,2 %) kot pri jemanju placeba po podatkih, združenih iz kliničnih študij s 406 bolniki, ki so jemali zdravilo, in 296 bolniki, ki so jemali placebo.
English: Baseline Week 8-24 10.7±2.2
Slovenian: razlika izhodišče teden 8-24 10,7 ± 2,2
English: yellow iron oxide (E 172), red iron oxide (E 172) and titanium dioxide (E 171).
Slovenian: rumeni železov oksid (E172), rdeči železov oksid (E172) in titanov dioksid (E171).
English: The safety and efficacy of Entacapone Orion in children below age 18 have not been established.
Slovenian: Varnost in učinkovitost zdravila Entacapone Orion pri otrocih, starih do 18 let, nista bili dokazani.
English: • antidepressants including desipramine, maprotiline, venlafaxine, paroxetine;
Slovenian: • antidepresive, vključno z dezipraminom, maprotilinom, venlafaksinom, paroksetinom;
English: Excipient with known effect Each film-coated tablet contains 0.53 mg soya lecithin.
Slovenian: Pomožna snov z znanim učinkom: Vsaka filmsko obložena tableta vsebuje 0,53 mg sojinega lecitina.
English: • Agitation;
Slovenian: • agitacija;
English: • Neuroleptic Malignant Syndrome (NMS) is a rare severe reaction to medicines used to treat disorders of the nervous system.
Slovenian: • nevroleptični maligni sindrom (NMS) je redka huda reakcija na zdravila za zdravljenje centralnega živčnega sistema.
English: • binge eating (eating large amounts of food in a short time period) or compulsive eating
Slovenian: • prenajedanje (uživanje velikih količin hrane v kratkem času) ali kompulzivno prenajedanje (uživanje večjih količin hrane kot običajno oziroma več, kot je potrebno za za potešitev lakote).
English: • dizziness, tiredness, increased sweating, fall;
Slovenian: • omotičnost, utrujenost, povečano znojenje, padec;
English: The following adverse reactions, listed below in Table 1, have been accumulated both from clinical studies with entacapone and since the introduction of entacapone into the market.
Slovenian: Neželeni učinki, ki so navedeni spodaj v preglednici 1, so bili opaženi v kliničnih študijah z entakaponom in po prihodu entakapona na trg.
English: If you take more Entacapone Orion than you should In the event of an overdose, consult your doctor, pharmacist or the nearest hospital immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Entacapone Orion, kot bi smeli Če ste vzeli prevelik odmerek, se takoj posvetujte z zdravnikom, farmacevtom ali najbližjo bolnišnico.
English: • decreased appetite, weight loss;
Slovenian: • zmanjšan apetit, izguba telesne mase;
English: What Entacapone Orion is and what it is used for
Slovenian: Kaj je zdravilo Entacapone Orion in za kaj ga uporabljamo
English: Entacapone Orion in association with levodopa may have a major influence on the ability to drive and use machines.
Slovenian: Entacapone Orion ima skupaj z levodopo pomemben vpliv na sposobnost vožnje in upravljanja s stroji.
English: Hence, to reduce levodopa-related dopaminergic adverse reactions, e.g. dyskinesias, nausea, vomiting and hallucinations, it is often necessary to adjust levodopa dosage within the first days to first weeks after initiating entacapone treatment.
Slovenian: Za zmanjšanje z levodopo povezanih dopaminergičnih neželenih učinkov, na primer diskinezij, navzeje, bruhanja in halucinacij, je v prvih dneh do prvih tednih po začetku zdravljenja z entakaponom pogosto potrebno prilagoditi odmerjanje levodope.
English: Study I: Daily On time (h) Entacapone (n=85) Placebo (n=86)
Slovenian: Študija I: Dnevno obdobje ‘ON' (ure) entakapon (n=85)
English: If you stop taking Entacapone Orion Do not stop taking Entacapone Orion unless your doctor tells you to.
Slovenian: Če ste prenehali jemati zdravilo Entacapone Orion Ne prekinite jemanja zdravila Entacapone Orion, razen če vam to naroči vaš zdravnik.
English: You may experience the following side effects:
Slovenian: Lahko pride do naslednjih neželenih učinkov:
English: In clinical studies, undesirable dopaminergic effects, e.g. dyskinesia, were more common in patients who received entacapone and dopamine agonists (such as bromocriptine), selegiline or amantadine compared to those who received placebo with this combination.
Slovenian: V kliničnih študijah so bili neželeni dopaminergični učinki, na primer diskinezija, pogostejši pri bolnikih, ki so dobivali entakapon in agoniste dopamina (na primer bromokriptin), selegilin ali amantadin, kot pri tistih, ki so skupaj s to kombinacijo dobivali placebo.
English: What Entacapone Orion is and what it is used for What you need to know before you take Entacapone Orion How to take Entacapone Orion Possible side effects
Slovenian: Kaj je zdravilo Entacapone Orion in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Entacapone Orion Kako jemati zdravilo Entacapone Orion Možni neželeni učinki
English: Patients being treated with entacapone in association with levodopa and presenting with somnolence and/or sudden sleep onset episodes must be instructed to refrain from driving or engaging in activities where impaired alertness may put themselves or others at risk of serious injury or death (e.g. operating machines) until such recurrent episodes have resolved (see also section 4.4).
Slovenian: Bolnikom, ki se zdravijo z entakaponom v povezavi z levodopo in ki poročajo o zaspanosti in/ali nenadnih napadih spanja, je treba naročiti, naj ne upravljajo motornih vozil in naj se ne ukvarjajo z dejavnostmi, pri katerih lahko zaradi zmanjšane pazljivosti sebe ali druge spravijo v nevarnost resne poškodbe ali smrti (na primer uporaba strojev), dokler takšni ponavljajoči se napadi ne izginejo (glejte tudi poglavje 4.4).
English: The most frequent adverse reactions caused by entacapone relate to the increased dopaminergic activity and occur most commonly at the beginning of treatment.
Slovenian: Najpogostejši neželeni učinki, ki jih povzroča entakapon, so povezani s povečano dopaminergično aktivnostjo in se pojavijo najpogosteje na začetku zdravljenja.
English: It is characterised by stiffness, muscle twitching, shaking, agitation and confusion, coma, high body temperature, increased heart rate, and unstable blood pressure;
Slovenian: Za NMS so značilni okorelost, trzanje mišic, tresenje, agitacija, zmedenost, koma, zvišana telesna temperatura, pospešen utrip srca in nestabilen krvni tlak;
English: How to store Entacapone Orion Contents of the pack and other information
Slovenian: Shranjevanje zdravila Entacapone Orion Vsebina pakiranja in dodatne informacije
English: If you forget to take the Entacapone Orion tablet with your levodopa dose, you should continue the treatment by taking the next Entacapone Orion tablet with your next levodopa dose.
Slovenian: Če ste pozabili vzeti zdravilo Entacapone Orion Če pozabite vzeti tableto Entacapone Orion s svojim odmerkom levodope, nadaljujte zdravljenje tako, da vzamete naslednjo tableto Entacapone Orion z naslednjim odmerkom levodope.
English: • if you experience prolonged diarrhoea consult your doctor as it may be a sign of inflammation of the colon;
Slovenian: • če pride do dolgotrajne driske, se posvetujte z zdravnikom, saj gre lahko za znak vnetja debelega črevesa;
English: Do not use Entacapone Orion during pregnancy or if you are breast-feeding.
Slovenian: Ne jemljite zdravila Entacapone Orion v nosečnosti ali če dojite.
English: The recommended dose of Entacapone Orion is one 200 mg tablet with each levodopa dose.
Slovenian: Priporočeni odmerek zdravila Entacapone Orion je ena 200-miligramska tableta z vsakim odmerkom levodope.
English: • heart or artery disease events (e.g. chest pain).
Slovenian: • dogodki pri boleznih srca oziroma arterijskih boleznih (na primer bolečina v prsih).
English: NMS, including rhabdomyolysis and hyperthermia, is characterised by motor symptoms (rigidity, myoclonus, tremor), mental status changes (e.g. agitation, confusion, coma), hyperthermia, autonomic dysfunction (tachycardia, labile blood pressure) and elevated serum creatine phosphokinase.
Slovenian: Za NMS, skupaj z rabdomiolizo in hipertermijo, so značilni motorični simptomi (rigidnost, mioklonus, tremor), spremembe v mentalnem statusu (npr. agitiranost, zmedenost, koma), hipertermija, avtonomna disfunkcija (tahikardija, labilen krvni tlak) in povečana aktivnost serumske kreatinske fosfokinaze.
English: • Inflammation of the colon (colitis), inflammation of the liver (hepatitis) with yellowing of the skin and whites of the eyes;
Slovenian: • vnetje debelega črevesa (kolitis), vnetje jeter (hepatitis) z rumeno obarvanostjo kože in beločnic;
English: Entacapone belongs to a new therapeutic class, catechol-O-methyl transferase (COMT) inhibitors.
Slovenian: Entakapon pripada novi skupini zdravil, zaviralcem katehol-O-metiltransferaze (COMT).
English: • discolouration of skin, hair, beard and nails.
Slovenian: • sprememba barve kože, las, brade in nohtov.
English: Ischaemic heart disease events other than myocardial infarction (e.g. angina pectoris)
Slovenian: dogodki v zvezi z ishemično boleznijo srca, razen miokardnega infarkta (na primer angina pektoris)
English: Suddenly stopping Entacapone Orion and other medicines to treat Parkinson´s disease may result in unwanted side effects.
Slovenian: Nenadna prekinitev zdravljenja z zdravilom Entacapone Orion in drugimi zdravili za Parkinsonovo bolezen lahko povzroči neželene učinke.
English: However, the experience of the clinical use of entacapone with several medicinal products, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine, and medicinal products that are metabolised by COMT (e.g. catechol structured compounds: rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine,alpha-methyldopa, apomorphine, and paroxetine) is still limited.
Slovenian: Vendar so izkušnje s klinično uporabo entakapona z več zdravili, med drugim z zaviralci MAO-A, tricikličnimi antidepresivi, zaviralci ponovnega privzema noradrenalina, kot so desipramin, maprotilin in venlafaksin, in zdravili, ki jih presnavlja COMT (na primer spojine s kateholno skupino: rimiterol, izoprenalin, adrenalin, noradrenalin, dopamin, dobutamin, alfa-metildopa, apomorfin in paroksetin), še omejene.