FrancophonIA/ELRC3.0 huggingface dataset:
English: Co-administration of hydroxyzine with drugs known to prolong the QT interval and/or induce Torsade de Pointes e.g. class IA (e.g. quinidine, disopyramide) and III antiarrhythmics (e.g. amiodarone, sotalol), some antihistamines, some antipsychotics (e.g. haloperidol), some antidepressants (e.g. citalopram, escitalopram), some antimalarial drugs (e.g. mefloquine), some antibiotics (e.g. erythromycin, levofloxacin, moxifloxacin), some antifungal agents (e.g. pentamidine), some gastro-intestinal medicines (e.g. prucalopride), some medicines used in cancer (e.g., toremifene, vandetanib), methadone, increase the risk of cardiac arrhythmia.
Slovenian: Sočasno dajanje hidroksizina z zdravili, za katera je znano, da podaljšujejo interval QT in/ali povzročajo torsade de pointes, npr. antiaritmiki razreda IA (npr. kinidin, dizopiramid) in III (npr. amiodaron, sotalol), nekateri antihistaminiki, nekateri antipsihotiki (npr. haloperidol), nekateri antidepresivi (npr. citalopram, escitalopram), nekatera zdravila proti malariji (npr. meflokin), nekateri antibiotiki (npr. eritromicin, levofloksacin, moksifloksacin), nekateri antimikotiki (npr. pentamidin), nekatera gastro-intestinalna zdravila (npr. prukaloprid), nekatera zdravila proti raku (npr. toremifen, vandetanib), metadon, povečajo tveganje za srčno aritmijo.
English: Associations contraindicated
Slovenian: Kontraindicirane kombinacije
English: An ECG monitoring could be undertaken, because of the possibility of a heart rhythm problem such as QT interval prolongation or Torsade de Pointes.
Slovenian: Uvesti je treba spremljanje z EKG-jem, saj obstaja možnost za težave s srčnim ritmom, kot sta podaljšanje intervala QT ali torsade de pointes.
English: Do not <take> <use> X
Slovenian: Ne <jemljite><uporabljajte> zdravila X<
English: During post-marketing surveillance, there have been cases of QT interval prolongation and torsade de pointes in patients taking hydroxyzine.
Slovenian: Med spremljanjem v obdobju trženja zdravila obstajajo poročila o primerih bolnikov s podaljšanjem intervala QT in torsade de pointes pri bolnikih, ki so jemali hidroksizin.
English: • heart problems or high blood pressure (e.g., amiodarone, quinidine, disopyramide, sotalol)
Slovenian: • težav s srcem ali visokega krvnega tlaka (npr. amiodaron, kinidin, dizopiramid, sotalol)
English: If you <take> <use> more X than you should
Slovenian: <Če ste <vzeli><uporabili> večji odmerek zdravila X, kot bi smeli>
English: Hydroxyzine is metabolized by alcohol dehydrogenase and CYP3A4/5 and an increase in hydroxyzine blood concentrations may be expected when hydroxyzine is co-administered with drugs known to be potent inhibitors of these enzymes.
Slovenian: Kombinacije, pri katerih je potrebna previdnost pri uporabi Hidroksizin se presnavlja z alkohol dehidrogenazo in encimi CYP3A4/5, zato se lahko pričakuje povečanje koncentracij hidroksizina v krvi, če se hidroksizin daje sočasno z zdravili, za katera je znano, da so močni zaviralci teh encimov.
English: Patients with a known risk factor to QT interval prolongation including a known cardiovascular disease, significant electrolytes imbalance (hypokalaemia, hypomagnesaemia), family history of sudden cardiac death, significant bradycardia, concomitant use with drugs known to prolong the QT interval and/or induce Torsade de Pointes (see sections 4.4 and 4.5).
Slovenian: Bolniki z znanim dejavnikom tveganja za podaljšanje intervala QT, vključno z znano kardiovaskularno boleznijo, pomembnim neravnovesjem elektrolitov (hipokaliemija, hipomagneziemija), družinsko anamnezo nenadne srčne smrti, pomembno bradikardijo, sočasno uporabo zdravil, za katera je znano, da podaljšujejo interval QT in/ali povzročajo torsade de pointes (glejte poglavji 4.4 in 4.5).
English: • psychoses (e.g. haloperidol)
Slovenian: • psihoz (npr. haloperidol)
English: Hydroxyzine should be used at the lowest effective dose and for the shortest possible duration.
Slovenian: Hidroksizin je treba uporabljati v najmanjšem še učinkovitem odmerku in najkrajši možni čas.
English: • bacterial infections (e.g. the antibiotics erythromycin, moxifloxacin, levofloxacin)
Slovenian: • bakterijskih okužb (npr. antibiotike eritromicin, moksifloksacin, levofloksacin)
English: • cancer (e.g. toremifene, vandetanib)
Slovenian: • raka (npr. toremifen, vandetanib)
English: Caution with bradycardia and hypokalaemia-inducing drugs.
Slovenian: Pozornost je potrebna pri zdravilih, ki povzročajo bradikardijo in hipokaliemijo.
English: • malaria (e.g. mefloquine)
Slovenian: • malarije (npr. meflokin)
English: X should be used at the lowest effective dose and the treatment period should be as short as possible.
Slovenian: Zdravilo X je treba uporabljati v najmanjšem še učinkovitem odmerku in najkrajši možni čas.
English: In the elderly, the maximum daily dose is 50 mg per day.
Slovenian: Pri starejših je največji dnevni odmerek 50 mg na dan.
English: Check with your <doctor> <or> <pharmacist> if you are not sure.>
Slovenian: Če ste negotovi, se posvetujte z <zdravnikom><ali>< farmacevtom>.>
English: Annex III Amendments to relevant sections of the summary of product characteristics and package leaflets
Slovenian: Dopolnila, ki se vključijo v ustrezna poglavja povzetka glavnih značilnosti zdravila in navodila za uporabo
English: Section 4.8 Undesirable effects The following wording should be added to this section: Not known: ventricular arrhythmias (e.g. Torsade de Pointes), QT interval prolongation (see section 4.4).
Slovenian: Neznana pogostnost: ventrikularne aritmije (npr.torsade de pointes), podaljšanje intervala QT (glejte poglavje 4.4).
English: <Always <take> <use> this medicine exactly as your doctor <or pharmacist> has told you.
Slovenian: <jemanju><uporabi> tega zdravila natančno upoštevajte navodila zdravnika <ali><farmacevta>.
English: • fungal infections (e.g. pentamidine)
Slovenian: • glivičnih okužb (npr. pentamidin)
English: In adults and children over 40 kg in weight, the maximum daily dose is 100 mg per day in all indications.
Slovenian: Pri odraslih in otrocih s telesno maso nad 40 kg je največji dnevni odmerek 100 mg na dan za vse indikacije.
English: In children up to 40 kg, the maximum daily dose is 2 mg/kg/day.
Slovenian: Pri otrocih do 40 kg je največji dnevni odmerek 2 mg/kg/dan.
English: • gastro-intestinal disorders (e.g. prucalopride)
Slovenian: • prebavnih motenj (npr. prukaloprid)
English: In adults and children over 40 kg in weight, the maximum daily dose is 100 mg per day.
Slovenian: Pri odraslih in otrocih s telesno maso nad 40 kg je največji dnevni odmerek 100 mg na dan.
English: - if your ECG (electrocardiogram) shows a heart rhythm problem called “QT interval prolongation” - if you have or had a cardiovascular disease or if your heart rate is very low - if you have low salt levels in your body (e.g. low level of potassium or of magnesium) - if you are taking certain medicines for heart rhythm problems or medicines that may affect the heart rhythm (see “Other medicines and X”) - if anyone in your close family has died suddenly of heart problems
Slovenian: - če trenutno jemljete nekatera zdravila za težave s srčnim ritmom ali zdravila, ki lahko vplivajo na srčni ritem (glejte "Druga zdravila in zdravilo X").
English: Section 4.4 Special warnings and precautions for use The following wording should be added to this section:
Slovenian: Poglavje 4.4 Posebna opozorila in previdnostni ukrepi
English: In children up to 40 kg in weight, the maximum daily dose is 2 mg/kg/day.
Slovenian: Pri otrocih s telesno maso do 40 kg je največji dnevni odmerek 2 mg/kg/dan.
English: Section 3 “How to <take> <use> X”
Slovenian: Kako <jemati><uporabljati> zdravilo X <Pri
English: Section 4.2 - Posology and method of administration This section should be amended to reflect the following wording: [Product name] should be used at the lowest effective dose and for the shortest possible duration.
Slovenian: Zdravilo [ime zdravila] je treba uporabljati v najmanjšem še učinkovitem odmerku in najkrajši možni čas.
English: The marketing authorisation holders shall provide evidence in support of proportionate, feasible and effective measures to prevent the risk of overdose and minimise the risk of hepatic injury following intentional or accidental overdoses with modified release paracetamol containing products.
Slovenian: Imetniki dovoljenj za promet z zdravilom morajo predložiti dokaze v podporo sorazmernim, izvedljivim in učinkovitim ukrepom za preprečevanje tveganja za preveliko odmerjanje in zmanjšanje tveganja za poškodbo jeter po namernem ali nenamernem prevelikem odmerjanju zdravil, ki vsebujejo paracetamol s prirejenim sproščanjem.
English: For the suspension of products containing paracetamol, modified and prolonged to be lifted, the competent authorities shall ensure that the below conditions have been completed by the marketing authorisation holders.
Slovenian: Za preklic začasnega umika dovoljenj za promet z zdravili, ki vsebujejo paracetamol s prirejenim in podaljšanim sproščanjem, morajo pristojni organi zagotoviti, da so imetniki dovoljenj za promet z zdravilom izpolnili spodnje pogoje.
English: Conditions for lifting the suspension of the marketing authorisations
Slovenian: Pogoji za preklic začasnega umika dovoljenj za promet z zdravilom
English: Annex III Conditions for lifting the suspension of the marketing authorisations
Slovenian: Priloga III Pogoji za preklic začasnega umika dovoljenj za promet z zdravilom
English: Strength Pharmaceutical Form Route of administration Packaging
Slovenian: Farmacevtska oblika
English: Date of first authorisation: 19 September 2013 Date of latest renewal: 26 July 2018
Slovenian: Datum prve odobritve: 19. september 2013 Datum zadnjega podaljšanja: 26. julij 2018
English: You must keep in regular contact with your doctor.
Slovenian: Redno morate biti v stiku s svojim zdravnikom.
English: Interaction not studied.
Slovenian: Interakcij niso preučili.
English: Black or African Heritage Asian
Slovenian: Črnci ali afriškega porekla
English: This is to make sure that your medicine is fully effective.
Slovenian: Tako boste zagotovili polno učinkovitost vašega zdravila.
English: Recommended dose for adults:
Slovenian: Običajen odmerek za odrasle:
English: Always take the tablet with food.
Slovenian: Tableto vedno vzemite s hrano.
English: You may still develop infections or other illnesses associated with HIV infection.
Slovenian: Še vedno se vam lahko pojavijo okužbe ali druge bolezni, povezane z okužbo z virusom HIV.
English: Discuss with your doctor the precautions needed to avoid infecting other people.
Slovenian: Z zdravnikom se pogovorite o potrebnih previdnostnih ukrepih za preprečevanje okužbe drugih ljudi.
English: PC: {number} SN: {number} NN: {number} [Outer packaging only]
Slovenian: PC: {številka} SN: {številka} NN: {številka} [samo na zunanji ovojnini]
English: Wait and take the next dose, with food, at your usual time.
Slovenian: Počakajte in vzemite naslednji odmerek s hrano ob svojem običajnem času.
English: Cobicistat levels decrease and may not provide sufficient boosting.
Slovenian: Ravni kobicistata se zmanjšajo in morda ne zagotovijo zadostne okrepitve.
English: The amounts of these medicines in your blood may decrease during pregnancy, which may stop them from working properly.
Slovenian: Količina teh zdravil v krvi se lahko med nosečnostjo zmanjša, kar lahko prepreči njihovo pravilno delovanje.
English: Always take the dose recommended by your doctor.
Slovenian: Vedno vzemite odmerek, ki vam ga je priporočil zdravnik.
English: These are mentioned above under the heading “Do not take Tybost-If you are taking medicines containing any one of the following”.
Slovenian: Ta so navedena zgoraj, pod naslovom »Ne jemljite zdravila Tybost - če jemljete zdravila, ki vsebujejo kaj od naslednjega«.
English: • increased appetite, disturbed sense of taste, dry mouth
Slovenian: • povečan apetit, spremenjen občutek za okus, suha usta
English: The use of Tybost in children and adolescents has not yet been studied.
Slovenian: Uporabe zdravila Tybost pri otrocih in mladostnikih še niso preučili.
English: In the ritonavir group, genotypic data was available for all 19 virologic failures.
Slovenian: V skupini z ritonavirjem so bili podatki za genotipizacijo na voljo pri vseh 19 viroloških neuspehih.
English: • yellowing of the skin and/or eyes (jaundice)
Slovenian: • porumenelost kože in/ali oči (zlatenica)
English: NC = not calculated
Slovenian: NI = ni izračunano
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), and not known (frequency cannot be estimated from the available data).
Slovenian: Pogostnost je definirana kot zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000) in neznana pogostnost (pogostnosti ni mogoče oceniti iz razpoložljivih podatkov).
English: In some cases, your doctor may need to adjust your dose or check the levels of medicine in your blood.
Slovenian: V nekaterih primerih bo moral zdravnik prilagoditi vaš odmerek ali opraviti preiskave ravni zdravila v vaši krvi.
English: Further dose reduction of rifabutin has not been studied.
Slovenian: Dodatnega zmanjšanja odmerka rifabutina niso preučili.
English: The film-coated tablet should not be chewed or crushed.
Slovenian: Filmsko obložene tablete se ne sme žvečiti ali zdrobiti.
English: When treating HIV infection, it is not always possible to tell whether some of the unwanted effects are caused by Tybost or by other medicines that you are taking at the same time, or by the HIV disease itself.
Slovenian: Pri zdravljenju okužbe z virusom HIV ni vedno mogoče povedati, ali nekatere od naštetih neželenih učinkov povzroča zdravilo Tybost ali druga zdravila, ki jih jemljete sočasno, ali sama bolezen HIV.
English: Effects on the liver
Slovenian: Učinki na jetra
English: • If you are allergic to cobicistat or any of the other ingredients of this medicine (listed in section 6 of this leaflet).
Slovenian: • če ste alergični na kobicistat ali katero koli sestavino tega zdravila (navedeno v poglavju 6 tega navodila).
English: Alternative forms of contraception should be considered.
Slovenian: Uporabiti je treba druge oblike kontracepcije.
English: It should be kept in mind that a twice weekly dose of 150 mg may not provide an optimal exposure to rifabutin thus leading to a risk of rifabutin resistance and a treatment failure.
Slovenian: Vedeti je treba, da morda odmerek 150 mg dvakrat tedensko ne zagotavlja optimalne izpostavljenosti rifabutinu, kar ima lahko za posledico rezistenco na rifabutin in neuspeh zdravljenja.
English: Do not give this medicine to children and adolescents under 18 years of age.
Slovenian: Otrokom in mladostnikom, starim manj kot 18 let, ne dajajte tega zdravila.
English: Talk to your doctor if you are taking
Slovenian: Posvetujte se z zdravnikom, če jemljete
English: This medicine does not directly treat your HIV infection.
Slovenian: To zdravilo ne zdravi okužbe z virusom HIV neposredno.
English: d Includes patients who discontinued due to adverse event (AE) or death at any time point from day 1 through the time window if this resulted in no virologic data on treatment during the specified window.
Slovenian: d Vključuje bolnike, ki so prenehali sodelovati zaradi neželenih učinkov ali smrti, kadar koli od 1. dne do konca časovnega okna, če zaradi tega v določenem oknu ni bilo viroloških podatkov o zdravljenju.
English: As a result, the amounts of Tybost or other medicines in your blood may be affected.
Slovenian: To lahko posledično vpliva na količino zdravila Tybost ali drugih zdravil v vaši krvi.
English: Contact your doctor or nearest emergency department immediately for advice.
Slovenian: Takoj se posvetujte s svojim zdravnikom ali poiščite najbližjo urgentno ambulanto.
English: Treatment of overdose with cobicistat consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient.
Slovenian: Zdravljenje prevelikega odmerka s kobicistatom zajema splošne podporne ukrepe, ki vključujejo spremljanje vitalnih znakov in opazovanje kliničnega stanja bolnika.
English: • Tell your doctor immediately if you are pregnant, think you may be pregnant or are planning to have a baby.
Slovenian: • Zdravnika takoj obvestite, če zanosite, menite, da bi lahko bili noseči, ali načrtujete zanositev.
English:  Tell your doctor if you are taking these or any other medicines.
Slovenian:  Povejte svojemu zdravniku, če jemljete ta ali katera koli druga zdravila.
English: Tybost has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Tybost nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: The serum digoxin concentrations should be monitored and used for titration of digoxin dose to obtain the desired clinical effects.
Slovenian: Koncentracije digoksina v serumu je treba spremljati in uporabiti za titriranje odmerka digoksina, da se dosežejo želeni klinični učinki.
English: If you are affected while taking Tybost, do not drive and do not use any tools or machines.
Slovenian: Če se tudi vam pojavi to med jemanjem zdravila Tybost, ne vozite in ne uporabljajte orodij ali strojev.
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Slovenian: Terapijo mora začeti zdravnik, ki že ima izkušnje z zdravljenjem okužbe z virusom HIV.
English: A long term carcinogenicity study in mice did not show any carcinogenic potential.
Slovenian: Dolgoročne študije kancerogenosti pri miših niso pokazale kancerogenega potenciala.
English: The safety and efficacy of cobicistat in children aged 0 to less than 18 years have not been established (see section 5.1).
Slovenian: Varnost in učinkovitost kobicistata pri otrocih, starih od 0 do manj kot 18 let, nista bili dokazani (glejte poglavje 5.1).
English: CCR5 Antagonists Maraviroc
Slovenian: Antagonisti CCR5 maravirok
English: What Tybost is and what it is used for
Slovenian: Kaj je zdravilo Tybost in za kaj ga uporabljamo
English: In order to avoid transmission of HIV to the infant it is recommended that HIV infected women do not breast-feed their infants under any circumstances.
Slovenian: Za preprečitev prenosa HIV na dojenčka se priporoča, da s HIV okužene ženske v nobenem primeru ne dojijo.
English: Tybost should be taken orally, once daily with food (see section 5.2).
Slovenian: Zdravilo Tybost se jemlje peroralno, enkrat dnevno s hrano (glejte poglavje 5.2).
English: Cobicistat has not been studied in patients receiving dialysis, and, therefore, no recommendation can be made for these patients.
Slovenian: Kobicistata niso preučili pri bolnikih, ki so na dializi, zato priporočil za te bolnike ni mogoče dati.
English: It is taken with atazanavir or darunavir (both protease inhibitors) and acts as a booster (enhancer) to help improve their effect.
Slovenian: Jemlje se z atazanavirjem ali darunavirjem (oba sta zaviralca proteaze) in deluje kot ojačevalec (spodbujevalec), kot pomoč pri izboljšanju njunega učinka.
English: (dyspepsia), feeling bloated, wind (flatulence)
Slovenian: (dispepsija), občutek napihnjenosti, vetrovi (flatulenca)
English: • One tablet each day by mouth, with food.
Slovenian: • Ena tableta vsak dan, ki jo zaužijete s hrano.
English: The other ingredients are
Slovenian: Druge sestavine zdravila so
English: • HMG Co-A reductase inhibitors: lovastatin, simvastatin
Slovenian: • zaviralci HMG Co-A reduktaze: lovastatin, simvastatin
English: • within 12 hours of the time you usually take Tybost, you must take the tablet as soon as possible.
Slovenian: • v roku 12 ur od časa, ko zdravilo Tybost običajno vzamete, morate tableto vzeti čim prej.
English: Voriconazole should not be used unless the possible benefit is considered to outweigh the risks associated with the unpredictable effect on plasma concentrations.
Slovenian: Vorikonazola se ne sme uporabiti, razen če se oceni, da so možne koristi večje od tveganj, povezanih z nepredvidljivim učinkom na koncentracije v plazmi.
English: It does this by slowing down the breakdown of atazanavir and darunavir which will make them stay in the body for longer.
Slovenian: To stori z upočasnitvijo razkroja atazanavirja in darunavirja, ki tako v telesu ostaneta dlje časa.
English: • alpha 1-adrenoreceptor antagonists: alfuzosin
Slovenian: • antagonisti adenoreceptorjev alfa 1: alfuzosin
English: Tybost may interact with other substances.
Slovenian: Zdravilo Tybost lahko medsebojno deluje z drugimi snovmi.
English: It is not known if the active substance in this medicine can pass into human breast milk.
Slovenian: Ni znano, ali lahko učinkovina v tem zdravilu prehaja v materino mleko.
English: Tybost is used in adults aged 18 years and over who are infected with HIV, the virus that causes acquired immunodeficiency syndrome (AIDS).
Slovenian: Zdravilo Tybost se uporablja pri odraslih, starih 18 let in več, ki so okuženi z virusom HIV, ki povzroča sindrom pridobljene imunske pomanjkljivosti (AIDS).
English: The median terminal plasma half-life of cobicistat following administration of Tybost is approximately 3-4 hours.
Slovenian: Mediani končni razpolovni čas kobicistata v plazmi po uporabi zdravila Tybost je približno 3-4 ure.
English: Stopping Tybost and atazanavir or darunavir may reduce the success of future treatments prescribed by your doctor.
Slovenian: Prenehanje jemanja zdravila Tybost in atazanavirja ali darunavirja lahko zmanjša uspeh prihodnjih zdravljenj, ki vam jih predpiše vaš zdravnik.
English: Alternative forms of contraception should be considered (see section 4.5).
Slovenian: Razmisliti je treba o drugih oblikah kontracepcije (glejte poglavje 4.5).
English: If the combination is needed, the recommended dose of rifabutin is 150 mg 3 times per week on set days (for example MondayWednesday-Friday).
Slovenian: Če je ta kombinacija potrebna, je priporočeni odmerek rifabutina 150 mg trikrat tedensko na določene dni (na primer ponedeljek-sreda-petek).
English: If you are taking Tybost with atazanavir your doctor will discuss the potential benefits and risks of taking Tybost to you and your child.
Slovenian: Če jemljete zdravilo Tybost z atazanavirjem, se bo zdravnik z vami pogovoril o možnih koristih in tveganjih zdravljenja z zdravilom Tybost za vas in vašega otroka.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with cobicistat in one or more subsets of the paediatric population in treatment of HIV-1 infection (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij s kobicistatom za eno ali več podskupin pediatrične populacije za zdravljenje okužbe z virusom HIV-1 (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: • protein in the urine (proteinuria)
Slovenian: • beljakovine v urinu (proteinurija)
English: Cobicistat is 97-98% bound to human plasma proteins and the mean plasma to blood drug concentration ratio was 2.
Slovenian: Kobicistat se 97-98 % veže na humane plazemske proteine, povprečno razmerje med koncentracijo zdravila v plazmi in krvi pa je bilo 2.
English: No data are available on which to make a dose recommendation for patients over the age of 65 years (see section 5.2).
Slovenian: Podatkov, na osnovi katerih bi lahko priporočili odmerke za bolnike, starejše od 65 let, ni na voljo (glejte poglavje 5.2).
English: Effects on drug levels Mean percent change in AUC,
Slovenian: Učinki na koncentracije učinkovin Povprečna sprememba AUC,
English: These interactions are based on either drug interaction studies or predicted interactions due to the expected magnitude of interaction and potential for serious and/or life-threatening events or loss of efficacy.
Slovenian: Opisane interakcije temeljijo na študijah interakcij zdravila ali na interakcijah, napovedanih na podlagi pričakovanega obsega interakcij in možnih resnih in/ali življenjsko nevarnih neželenih učinkov ali izgube učinkovitosti.
English: • feeling depressed
Slovenian: • občutek potrtosti