FrancophonIA/ELRC3.0 huggingface dataset:
English: You know that you have had low levels of white blood cells in the past (which may or may not have been caused by other medicines).
Slovenian: Če je tako, vam bo zdravnik med jemanjem zdravila Seroquel SR preverjal koncentracijo sladkorja v krvi, veste, da ste v preteklosti imeli nizko raven belih krvnih celic (kar so lahko ali pa tudi ne povzročila druga zdravila), če ste starejša oseba z demenco (poslabšanim delovanjem možganov).
English: The efficacy of Seroquel XR in the treatment of schizophrenia was demonstrated in one 6-week placebo-controlled trial in patients who met DSM-IV criteria for schizophrenia, and one activecontrolled Seroquel immediate release-to-Seroquel XR switching study in clinically stable outpatients with schizophrenia.
Slovenian: Učinkovitost zdravila Seroquel SR za zdravljenje shizofrenije so dokazali v enem 6-tedenskem s placebom kontroliranem preskušanju pri bolnikih, ki so izpolnjevali merila za shizofrenijo po DSM
English: Neuroleptic malignant syndrome 1
Slovenian: maligni nevroleptični sindrom
English: If you suddenly stop taking Seroquel XR, you may be unable to sleep (insomnia), you may feel sick (nausea), or you may experience headache, diarrhoea, being sick (vomiting), dizziness or irritability.
Slovenian: Če zdravilo Seroquel SR nehate jemati nenadoma, se lahko pojavijo nespečnost, slabost v želodcu, glavobol, driska, bruhanje, omotica ali razdražljivost.
English: Quetiapine is extensively metabolized by the liver.
Slovenian: Kvetiapin se obsežno presnovi v jetrih.
English: MARKETING AUTHORISATION NUMBER(S) [To be completed nationally]
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET Izpolni država članica
English: Seroquel XR should be administered prior to bedtime.
Slovenian: Zdravilo Seroquel SR je treba uporabiti pred spanjem.
English: Information from clinical trials has shown an increased risk of suicidal thoughts and/or suicidal behaviour in young adults aged less than 25 years with depression.
Slovenian: Podatki iz kliničnih preskušanj kažejo, da pri mlajših odraslih (starih manj od 25 let) z depresijo obstaja večje tveganje za pojav samomorilnega vedenja in/ali samomorilnega vedenja.
English: • Do not drink grapefruit juice while you are taking Seroquel XR .
Slovenian: • Ne pijte grenivkinega soka, medtem ko jemljete zdravilo Seroquel SR. Grenivkin sok lahko vpliva na delovanje zdravila.
English: 6.4 Special precautions for storage This medicinal product does not require any special storage conditions.
Slovenian: Za shranjevanje zdravila niso potrebna posebna navodila.
English: Contains lactose monohydrate.
Slovenian: Pomožna snov: laktoza monohidrat.
English: This medicinal product is authorised in the Member States of the EEA under the following names:
Slovenian: To zdravilo je odobreno v državah članicah EGP pod naslednjimi imeni: Avstrija: Seroquel XR
English: In placebo-controlled clinical trials with children and adolescent patients treated with Seroquel, quetiapine was associated with an increased incidence of extrapyramidal symptoms (EPS) compared to placebo in patients treated for schizophrenia and bipolar mania (see section 4.8).
Slovenian: V kliničnih, s placebom kontroliranih preskušanjih zdravljenja shizofrenije in bipolarne motnje z zdravilom Seroquel pri otrocih in mladostnikih je kvetiapin spremljala večja incidenca ekstrapiramidnih simptomov (EPS) kot placebo (glejte poglavje 4.8).
English: SE - Sweden AstraZeneca AB AstraZeneca Sverige SE-151 85 Södertälje Sweden
Slovenian: SE-151 85 Södertälje Švedska
English: Do not split, chew or crush the tablets.
Slovenian: Tablet ne lomite, ne grizite in ne drobite.
English: Blood and lymphatic system disorders
Slovenian: Bolezni krvi in limfatičnega sistema Pogosti:
English: Iron oxide, yellow (E172) (50, 200 and 300 mg tablets) Iron oxide, red (E172) (50 mg tablets) 6.2 Incompatibilities
Slovenian: Obloga hipromeloza (E464) makrogol titanov dioksid (E171) rumen železov oksid (E172) (50-, 200- in 300-mg tablete) rdeč železov oksid (E172) (50-mg tablete)
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER
Slovenian: IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM Izponi država članica
English: The pharmacokinetics of lithium were not altered when co-administered with quetiapine.
Slovenian: Farmakokinetika litija se med sočasno uporabo s kvetiapinom ni spremenila.
English: In a short-term placebo-controlled monotherapy trial in elderly patients with major depressive disorder, the aggregated incidence of extrapyramidal symptoms was 9.0% for Seroquel XR and 2.3% for placebo.
Slovenian: V kratkotrajnih, s placebom kontroliranih kliničnih preskušanjih monoterapije pri starejših bolnikih z MDD je bila skupna incidenca ekstrapiramidnih simptomov med uporabo zdravila Seroquel SR 9,0 % in med uporabo placeba 2,3 %.
English: In placebo controlled clinical trials of adult patients quetiapine was associated with an increased incidence of extrapyramidal symptoms (EPS) compared to placebo in patients treated for major depressive episodes in bipolar disorder and major depressive disorder (see sections 4.8 and 5.1).
Slovenian: V kliničnih, s placebom kontroliranih preskušanjih je bil kvetiapin med zdravljenjem depresivnih epizod pri bipolarni motnji in MDD povezan z večjo incidenco ekstrapiramidnih simptomov (EPS) kot placebo (glejte poglavji 4.8 in 5.1).
English: Metabolism and nutritional disorders Very common:
Slovenian: Presnovne in prehranske motnje Pogosti:
English: Extrapyramidal Symptoms
Slovenian: Ekstrapiramidni simptomi
English: 1 blister of 10 tablets
Slovenian: 1 pretisni omot, ki vsebuje 10 tablet
English: The pharmacokinetics of quetiapine were not significantly altered by co-administration of the antipsychotics risperidone or haloperidol.
Slovenian: Sočasna uporaba antipsihotikov risperidona ali haloperidola ni bistveno spremenila farmakokinetike kvetiapina.
English: In short-term placebo-controlled clinical trials with Seroquel in paediatric patients with schizophrenia, the incidence of suicide related events was 1.4% (2/147) for quetiapine and 1.3% (1/75) for placebo in patients <18 years of age.
Slovenian: Samomor/samomorilne misli ali klinično poslabšanje V kratkotrajnih s placebom kontroliranih kliničnih preskušanjih zdravila Seroquel pri pediatričnih bolnikih s shizofrenijo je bila incidenca s samomorom povezanih dogodkov med bolniki, starimi < 18 let, 1,4 % (2/147) pri kvetiapinu in 1,3 % (1/75) pri placebu.
English: Do not take Seroquel XR if: you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel XR (see section 6: Further information) you are taking any of the following medicines: - some medicines for HIV - azole medicines (for fungal infections) - erythromycin or clarithromycin (for infections) - nefazodone (for depression).
Slovenian: Dodatne informacije); če uporabljate katero od naštetih zdravil: - nekatera zdravila za zdravljenje HIV, - nekatera zdravila proti glivičnim okužbam (iz skupine azolov), - eritromicin, klaritromicin (zdravila proti okužbam), - nefazodon (zdravilo proti depresiji).
English: Seroquel Depot United Kingdom Seroquel XL
Slovenian: Slovenija: Seroquel SR Španija: Seroquel Prolong Švedska: Seroquel Depot Velika Britanija: Seroquel XL
English: GROUNDS FOR AMENDMENT OF THE SUMMARY OF PRODUCT CHARACTERISTICS, AND PACKAGE LEAFLET
Slovenian: PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA IN NAVODIL ZA UPORABO
English: Quetiapine should be discontinued in patients with a neutrophil count <1.0 X 109/L.
Slovenian: Pri bolnikih s številom nevtrofilcev < 1,0 x 109/l morate uporabo kvetiapina prekiniti.
English: - The CHMP concluded on a positive benefit risk ratio for Seroquel XR as add-on treatment of major depressive episodes in patients with major depressive disorder, who have had suboptimal response to initial antidepressant monotherapy further to consideration of the safety profile of Seroquel.
Slovenian: - je CHMP po proučitvi varnostnega profila za zdravilo Seroquel zaključil, da je razmerje med tveganjem in koristmi pozitivno za zdravilo Seroquel XR kot dodatno zdravljenje velikih depresivnih epizod pri bolnikih z veliko depresivno motnjo, ki so imeli suboptimalen odziv na začetno antidepresivno monoterapijo;
English: feeling restless or muscle stiffness without pain.
Slovenian: Med takšnimi so težave z začenjanjem mišičnih gibov, tresenje, občutek nemira ali togost mišic, ki je ne spremljajo bolečine.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER [To be completed nationally] {Name and Address} <{tel}>
Slovenian: IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM Izpolni država članica
English: Severe neutropenia (neutrophil count <0.5 X 109/L) has been uncommonly reported in quetiapine clinical trials.
Slovenian: Občasno so v kliničnih preskušanjih kvetiapina opažali hudo nevtropenijo (število nevtrofilcev < 0,5 x 109/l).
English: • Allergic reactions that may include raised lumps (weals), swelling of the skin and swelling around the mouth.
Slovenian: ▪ napadi krčev ali konvulzije, ▪ alergijske reakcije, ki lahko vključujejo izbočene otekline (modrice), otekanje kože in predela okoli ust, ▪ neprijeten občutek v nogah (tako imenovan sindrom nemirnih nog), težave pri požiranju, nekontrolirani gibi, večinoma obraza ali jezika
English: Magnesium stearate
Slovenian: PRETISNA FOLIJA
English: 0319 Oslo, Norway
Slovenian: 28033 Madrid, Španija
English: Cardiac disorders Common:
Slovenian: Zapoznela diskinezija:
English: Always take Seroquel XR exactly as your doctor has told you.
Slovenian: Pri jemanju zdravila Seroquel SR natančno upoštevajte zdravnikova navodila.
English: Seroquel XR should not be taken if you are breast-feeding.
Slovenian: Zdravilo Seroquel SR ne jemljite v času dojenja.
English: Co-administration of quetiapine and phenytoin (another microsomal enzyme inducer) caused a greatly increased clearance of quetiapine by approx. 450%.
Slovenian: Zaradi tega medsebojnega delovanja se lahko koncentracija v plazmi zniža, to pa lahko vpliva na učinkovitost zdravljenja z zdravilom Seroquel SR. Sočasna uporaba kvetiapina in fenitoina (drugega induktorja mikrosomskih encimov) je močno povečala očistek kvetiapina za približno 450 %.
English: Whereas
Slovenian: Glede na to, da
English: • Disturbance in speech and language • Thoughts of suicide and worsening of your depression
Slovenian: Misli na samomor in poslabšanje
English: Member State Marketing Authorisation Holder
Slovenian: Imetnik dovoljenja za promet z zdravilom in izdelovalec Izpolni država članica
English: Tardive Dyskinesia:
Slovenian: Ledvična okvara:
English: Higher rates of extrapyramidal symptoms were seen in quetiapine treated patients compared to those treated with placebo in short-term, placebo-controlled clinical trials in MDD and bipolar depression.
Slovenian: (8) Pogostejše pojavljanje disfagije med uporabo kvetiapina v primerjavi s placebom so zabeležili samo v kliničnih preskušanjih pri bipolarni depresiji.
English: Orthostatic hypotension 4, 17 Venous thromboembolism1 Respiratory, thoracic and mediastinal disorder Common:
Slovenian: ortostatska hipotenzija venska trombembolija1
English: (6) Calculation of Frequency for these ADR's have only been taken from postmarketing data with the immediate release formulation of Seroquel (7) Fasting blood glucose ≥126mg/dL(≥7.0 mmol/L) or a non fasting blood glucose ≥200mg/dL (≥11.1 mmol/L) on at least one occasion (8) An increase in the rate of dysphagia with quetiapine vs. placebo was only observed in the clinical trials in bipolar depression (9) Based on >7% increase in body weight from baseline.
Slovenian: (7) Glukoza v krvi na tešče ≥ 126 mg/dl (≥7,0 mmol/l) ali glukoza v krvi, ki ni izmerjena na tešče, ≥ 200 mg/dl (≥11,1 mmol/l) vsaj enkrat.
English: Each tablet contains 200 mg quetiapine (as fumarate)
Slovenian: Vsaka tableta vsebuje 200 mg kvetiapina v obliki kvetiapinijevega fumarata.
English: Take special care with Seroquel XR
Slovenian: Bodite posebno pozorni pri jemanju zdravila Seroquel SR
English: INFORMATION IN BRAILLE Seroquel XR 200 mg
Slovenian: PODATKI V BRAILLOVI PISAVI seroquel SR 200 mg
English: Each tablet contains 150 mg quetiapine (as fumarate)
Slovenian: Vsaka tableta vsebuje 150 mg kvetiapina v obliki kvetiapinijevega fumarata.
English: Each tablet contains 400 mg quetiapine (as fumarate)
Slovenian: Vsaka tableta vsebuje 400 mg kvetiapina v obliki kvetiapinijevega fumarata.
English: Each tablet contains 300 mg quetiapine (as fumarate)
Slovenian: Vsaka tableta vsebuje 300 mg kvetiapina v obliki kvetiapinijevega fumarata.
English: Anaphylactic reaction6
Slovenian: zlatenica6
English: Seroquel XR 50 mg contains 50 mg quetiapine (as quetiapine fumarate) Excipient : 119 mg lactose (anhydrous) per tablet Seroquel XR 150 mg contains 150 mg quetiapine (as quetiapine fumarate) Excipient : 71 mg lactose (anhydrous) per tablet Seroquel XR 200 mg contains 200 mg quetiapine (as quetiapine fumarate) Excipient : 50 mg lactose (anhydrous) per tablet Seroquel XR 300 mg contains 300 mg quetiapine (as quetiapine fumarate) Excipient : 47 mg lactose (anhydrous) per tablet Seroquel XR 400 mg contains 400 mg quetiapine (as quetiapine fumarate) Excipient : 15 mg lactose (anhydrous) per tablet
Slovenian: Seroquel SR 50 mg tablete s podaljšanim sproščanjem Seroquel SR 150 mg tablete s podaljšanim sproščanjem Seroquel SR 200 mg tablete s podaljšanim sproščanjem Seroquel SR 300 mg tablete s podaljšanim sproščanjem Seroquel SR 400 mg tablete s podaljšanim sproščanjem kvetiapin
English: 6 blisters of 10 tablets
Slovenian: 6 pretisnih omotov, ki vsebujejo po 10 tablet
English: Weight gain has been seen in patients taking Seroquel XR.
Slovenian: Pri bolnikih, ki so prejemali zdravilo Seroquel SR, so opazili povečanje telesne mase.
English: HOW TO TAKE SEROQUEL XR
Slovenian: KAKO JEMATI ZDRAVILO SEROQUEL SR
English: INFORMATION IN BRAILLE Seroquel XR 150 mg
Slovenian: PODATKI V BRAILLOVI PISAVI seroquel SR 150 mg
English: LULuxembourg
Slovenian: PTPortugalska
English: INFORMATION IN BRAILLE Seroquel XR 50 mg
Slovenian: PODATKI V BRAILLOVI PISAVI seroquel SR 50 mg
English: Seroquel XR tablets contain 50 mg, 150 mg, 200 mg, 300 mg or 400 mg of quetiapine (as quetiapine fumarate).
Slovenian: Zdravilo Seroquel SR 150 mg vsebuje 150 mg kvetiapina (v obliki kvetiapinijevega fumarata).
English: Weight:
Slovenian: Presnova:
English: INFORMATION IN BRAILLE Seroquel XR 400 mg
Slovenian: PODATKI V BRAILLOVI PISAVI seroquel SR 400 mg
English: In a short-term placebo-controlled monotherapy trial with Seroquel in adolescent patients (13-17 years of age) with schizophrenia, the aggregated incidence of extrapyramidal symptoms was 12.9% for quetiapine and 5.3% for placebo, though the incidence of the individual adverse events (e.g. akathisia, tremor, extrapyramidal disorder, hypokinesia, restlessness, psychomotor hyperactivity, muscle rigidity, dyskinesia) did not exceed 4.1% in any treatment group.
Slovenian: Toda incidenca posameznih neželenih učinkov (npr. akatizije, tremorja, ekstrapiramidne motnje, hipokinezije, nemira, psihomotorične hiperaktivnosti, togosti mišic in diskinezije) v nobeni terapevtski skupini ni presegla 4,1 %.
English: For the treatment of depressive episodes in bipolar disorder Seroquel XR should be administered at bedtime.
Slovenian: Pri bolnikih z dejavniki tveganja za možgansko kap je treba zdravilo Seroquel SR uporabljati previdno.
English: Syncope 4, 17
Slovenian: odtegnitveni sindrom1,10
English: Jaundice6
Slovenian: SEŠvedska
English: (20) Cases of suicidal ideation and suicidal behaviours have been reported during Seroquel XR therapy or early after treatment discontinuation (see Sections 4.4 and 5.1).
Slovenian: V s placebom kontroliranih kliničnih preskušanjih s kvetiapinom je bila povprečna sprememba in pojav bolnikov, ki imajo klinično signifikantno spremembo QT, podobna med placebom in kvetiapinom (20) Med zdravljenjem ali kmalu po prenehanju zdravljenja z zdravilom Seroquel SR so bili opaženi primeri razmišljanja o samomoru in samomorilno vedenje (glejte poglavji 4.4in 5.1).
English: INFORMATION IN BRAILLE Seroquel XR 300 mg
Slovenian: PODATKI V BRAILLOVI PISAVI seroquel SR 300 mg
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 50 mg quetiapine (as fumarate)
Slovenian: Zdravilo Seroquel SR 50 mg vsebuje 50 mg kvetiapina (v obliki kvetiapinijevega fumarata).
English: Renal impairment:
Slovenian: Okvara jeter:
English: Coating
Slovenian: DENemčija
English: Dysphagia:
Slovenian: Konvulzije:
English: The efficacy of Seroquel XR was further demonstrated with significance versus placebo in an additional 3 week study.
Slovenian: Pomemben učinek zdravila Seroquel SR se je pojavil do 4. dne in se je ohranil vse do konca 3-tedenskega preskušanja.
English: Diabetes Mellitus 1,5,6, Psychiatric disorders Common:
Slovenian: anafilaktična reakcija6 Bolezni endokrinega sistema Pogosti:
English: Hypromellose
Slovenian: NONorveška
English: In placebo-controlled trials with quetiapine the mean change and the incidence of patients who have a shift to a clinically significant level is similar between quetiapine and placebo.
Slovenian: V kratkotrajnih, s placebom kontroliranih kliničnih preskušanjih pri MDD in bipolarni depresiji so med bolniki, ki so prejemali kvetiapin, zabeležili večje deleže ekstrapiramidnih simptomov kot med tistimi, ki so prejemali placebo.
English: • Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing.
Slovenian: Redki neželeni učinki (pojavijo se pri manj kot 1 od 1.000 oseb): ▪ zvišana telesna temperatura (vročina), dolgotrajno vnetje žrela ali razjede v ustih, hitrejše dihanje, znojenje, toge mišice, občutek hude zaspanosti ali omedlevice, ▪ porumenelost kože in očesnih beločnic (zlatenica), ▪ dolgotrajna in boleča erekcija (priapizem), moškim in ženskam lahko otečejo prsi in začnejo nepričakovano izločati mleko (galaktoreja), krvni strdki v žilah, zlasti v nogah (simptomi so oteklina, bolečina in rdečina na nogi), ki lahko potujejo skozi krvne žile v pljuča in povzročajo bolečine v prsih ter težave z dihanjem.
English: • Feeling sleepy (this may go away with time, as you keep taking Seroquel XR) (may lead to falls).
Slovenian: Zelo pogosti neželeni učinki (pojavijo se pri več kot 1 od 10 oseb): ▪ omotica (lahko povzroči padce), glavobol, suha usta, ▪ občutek zaspanosti (ta lahko sčasoma mine, ko nadaljujete jemanje zdravila Seroquel SR)
English: • Putting on weight.
Slovenian: Shranjujte pri temperaturi do 30 °C.
English: EXP
Slovenian: sinkopa
English: The absolute bioavailability is 88%.
Slovenian: Absolutna biorazpoložljivost je 88%.
English: ATC vet code: QP54AB51.
Slovenian: Oznaka ATC vet: QP54AB51.
English: Date of first authorisation: 15/01/2015 Date of last renewal:
Slovenian: Datum pridobitve dovoljenja za promet: 15/01/2015 Datum zadnjega podaljšanja dovoljenja za promet:
English: If you notice any side effects, even those not already listed in this package leaflet, or you think that the medicine has not worked, please inform your veterinary surgeon.
Slovenian: Če opazite kakršne koli stranske učinke, tudi tiste, ki niso navedeni v tem navodilu za uporabo ali mislite, da zdravilo ni delovalo, obvestite svojega veterinarja
English: The treatment schedule should be based on veterinary diagnosis and on the local epidemiological situation.
Slovenian: Razpored zdravljenja: Razpored zdravljenja bi moral temeljiti na diagnozi veterinarja in lokalni epidemiološki situaciji.
English: The terminal plasma half-life is approximately 2 weeks in dogs.
Slovenian: Končni razpolovni čas v plazmi je pri psih približno 2 tedna.
English: The systemic absorption of afoxolaner is high.
Slovenian: Sistemska absorbcija afoksolanerja je visoka.
English: 4 Chemin du Calquet 31000 Toulouse FRANCE
Slovenian: 4 Chemin du Calquet 31000 Toulouse Francija
English: Therefore, concomitant treatment with other P-gp substrates could lead to enhanced toxicity.
Slovenian: Zato bi sočasno zdravljenje z drugimi P-gp substrati lahko povečalo toksičnost zdravila.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the carton after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na škatli po EXP.
English: Treatment should continue until 1 month after the last exposure to mosquitoes.
Slovenian: Zdravljenje je potrebno nadaljevati še 1 mesec po zadnji izpostavljenosti komarjem.
English: To establish a treatment routine, it is recommended that the same day or date be used each month.
Slovenian: Za zagotavljanje rutinskega dajanja je priporočljivo zdraviti isti dan vsak mesec.
English: Severe cases may require prolonged monthly treatments.
Slovenian: V hujših primerih bolezni je lahko potrebnih več mesečnih zdravljenj.
English: In the absence of available data, treatment of puppies less than 8 weeks of age and dogs less than 2 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian.
Slovenian: Ker ni razpoložljivih podatkov, mora zdravljenje mladičev, mlajših od 8 tednov in/ali psov, lažjih od 2 kg temeljiti na oceni razmerja korist-tveganje odgovornega veterinarja.
English: It is a fermentation product of Streptomyces milbemycinicus.
Slovenian: Je produkt fermentacije Streptomyces milbemycinicus.
English: Milbemycin oxime:
Slovenian: Milbemicin oksim:
English: The absolute bioavailability is 81% and 65% for the A3 and A4 forms, respectively.
Slovenian: Absolutna biorazpoložljivost je 81% in 65% za A3
English: For dogs above 60 kg appropriate combinations of chewable tablets should be used.
Slovenian: Za pse nad 60 kg telesne mase je potrebno uporabiti ustrezno kombinacijo žvečljivih tablet iste ali različne jakosti.
English: This leads to hyperpolarisation of the neuromuscular membrane resulting in paralysis and death of the parasites.
Slovenian: To povzroči hiperpolarizacijo nevromišične membrane in povzroči paralizo in smrt parazita.
English: - Wash hands after use.
Slovenian: - Po rokovanju z zdravilom si umijte roke.
English: Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Slovenian: Ne uporabite v primerih preobčutljivosti na učinkovino ali na katero koli pomožno snov.
English: NEXGARD SPECTRA is not indicated for microfilariae clearance.
Slovenian: Zdravilo NEXGARD SPECTRA ni indicirano za očiščenje mikrofilarij.
English: Keep the blister in the outer carton in order to protect from light.
Slovenian: Pretisni omot shranjujte v zunanji ovojnini, da se zaščiti pred svetlobo.
English: Milbemycin oxime is a substrate for P-glycoprotein (P-gp) and therefore could interact with other P-gp substrates (for example, digoxin, doxorubicin) or other macrocyclic lactones.
Slovenian: Milbemicin oksim je substrat za P-glikoprotein (P-gp) in bi lahko zato bil v interakciji z drugimi P-gp substrati (na primer digoksinom, doksorubicinom) ali drugimi makrolitičnimi laktoni.
English: Both forms have low systemic clearance (75 ± 22 ml/h/kg for the A3 form and 41 ± 12 ml/h/kg for the A4 form).
Slovenian: Obe obliki imata nizek sistemski očistek (75 ± 22 ml/uro/kg za A3 obliko in 41 ± 12 ml/uro/kg za A4 obliko).
English: Isoxazolines, among the chloride channel modulators, bind to a distinct and unique target site within the insect GABACls, thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes.
Slovenian: Isoksazolini, med modulatorji kloridnih kanalčkov, se vežejo na določena in edinstvena mesta vezave v insektovih GABACLih, s čimer zavirajo pre- in post-sinaptični prehod kloridnih ionov skozi celično membrano.
English: Milbemycin oxime plasma concentrations peak quickly within the first 1-2 hours (Tmax) indicating that absorption from the chewable tablets is fast.
Slovenian: Maksimalna koncentracija milbemicin oksima v plazmi je dosežena hitro, v prvih 1-2 urah (Tmax), kar kaže, da je absorbcija iz žvečljive tablete zelo hitra.