FrancophonIA/ELRC3.0 huggingface dataset:
English: Lurasidone and its metabolites ID-14283, ID-14326, ID-20219 and ID-20220 correspond to approximately 11.4, 4.1, 0.4, 24 and 11% respectively, of serum radioactivity respectively.
Slovenian: Lurasidon in njegovi presnovki ID-14283, ID-14326, ID-20219 in ID-20220 ustrezajo približno 11,4 %, 4,1 %, 0,4 %, 24 % oziroma 11 % radioaktivnosti v serumu.
English: In a long-term trial designed to assess the maintenance of effect, lurasidone was more effective than placebo in maintaining symptom control and delaying relapse of schizophrenia.
Slovenian: V dolgoročnem preskušanju za oceno ohranitve učinka je bil lurasidon pri ohranitvi nadzora simptomov in zakasnitvi ponovitve shizofrenije učinkovitejši od placeba.
English: The following medicines may increase the level of lurasidone in your blood:
Slovenian: Naslednja zdravila lahko povečajo nivo lurasidona v krvi:
English: Placebo Lurasidone dose 18.5-74 mg (a) (b)
Slovenian: Odmerek lurasidona od 18,5 do 74 mg (a) (b)
English: The maximum dose should not exceed 148 mg once a day.
Slovenian: Največji odmerek ne sme preseči 148 mg enkrat na dan.
English: In the primary analysis of time to relapse in which patients that withdrew without relapse were censored at the time of withdrawal, patients on lurasidone showed a significantly longer time to relapse compared with patients on placebo (p=0.039).
Slovenian: Pri primarni analizi časa do ponovitve, v kateri so bolnike brez ponovitve po odtegnitvi zdravila ocenili v času odtegnitve, je bil čas do ponovitve pri bolnikih, ki so prejemali lurasidon, pomembno daljši kot pri bolnikih, ki so prejemali placebo (p=0,039).
English: • difficulty sleeping, tiredness, agitation and anxiety
Slovenian: • težave s spanjem, utrujenost, agitacija in tesnoba
English: The probability of all-cause discontinuation at Week 28 were 58.2% for lurasidone and 69.9% for placebo (p=0.072).
Slovenian: Verjetnost prekinitve zdravljenja zaradi vseh vzrokov je v 28. tednu za lurasidon znašala 58,2 %, za placebo pa 69,9 % (p=0,072).
English: Additionally, lurasidone was superior to placebo on the predefined secondary endpoint Clinical Global Impression - Severity (CGI-S) scale.
Slovenian: Razen tega je bil lurasidon boljši od placeba tudi pri vnaprej opredeljenem sekundarnem opazovanem dogodku, lestvici CGI-S (Clinical Global Impression - Severity).
English: • abnormal nerve impulses in the heart
Slovenian: • nenormalen prenos živčnih dražljajev v srcu
English: People with this disorder may also feel depressed, anxious, guilty, or tense.
Slovenian: Bolniki s shizofrenijo so lahko tudi depresivni, napeti in imajo občutek tesnobe ali krivde.
English: Lurasidone is a selective blocking agent of dopamine and monoamine effects.
Slovenian: Lurasidon je selektivni zaviralec učinka dopamina in monoaminov.
English: If prescribed to patients with Parkinson's disease, antipsychotic medicinal products may exacerbate the underlying parkinsonism symptoms.
Slovenian: Pri bolnikih s Parkinsonovo boleznijo lahko antipsihotiki poslabšajo že prisotne simptome parkinsonizma.
English: When lurasidone is coadministered with mild or moderate CYP3A4 inducers, the efficacy of lurasidone needs to be carefully monitored and a dose adjustment may be needed.
Slovenian: Če se lurasidon uporablja skupaj z blagimi ali zmernimi induktorji CYP3A4, je treba skrbno nadzirati učinkovitost lurasidona in odmerek po potrebi prilagoditi.
English: Lurasidone is metabolised into two active metabolites (ID-14283 and ID-14326) and two non-active metabolites (ID-20219 and ID-20220).
Slovenian: Lurasidon se presnovi do dveh aktivnih presnovkov (ID-14283 in ID-14326) in dveh neaktivnih presnovkov (ID-20219 in ID-20220).
English: In a long-term safety study clinically stable patients were treated using 37 - 111 mg lurasidone or risperidone 2 - 6 mg.
Slovenian: V dolgoročni študiji varnosti so se klinično stabilni bolniki zdravili z lurasidonom v odmerkih od 37 - 111 mg ali risperidonom v odmerkih od 2 - 6 mg.
English: Additional signs may include myoglobinuria (rhabdomyolysis) and acute renal failure.
Slovenian: Dodatni znaki lahko vključujejo mioglobinurijo (rabdomioliza) in akutno odpoved ledvic.
English: Sleepiness, dizziness and vision problems may occur during treatment with this medicine (see section 4, Possible side effects).
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Med zdravljenjem s tem zdravilom se lahko pojavijo zaspanost, omotica in težave z vidom (glejte poglavje 4, Možni neželeni učinki).
English: There are no or limited amount of data (less than 300 pregnancy outcomes) from the use of lurasidone in pregnant women.
Slovenian: Podatkov o uporabi lurasidona pri nosečnicah ni oziroma so omejeni (manj kot 300 izpostavljenih nosečnosti).
English: After having been treated for an acute episode and stabilized for a minimum of 12 weeks with lurasidone, patients were then randomised in a double-blind manner to either continue on lurasidone or on placebo until they experienced a relapse in schizophrenia symptoms.
Slovenian: Po zdravljenju akutne epizode in najmanj 12-tedenski stabilizaciji z lurasidonom so bolnike nato randomizirali na dvojno slep način tako, da so še naprej prejemali lurasidon ali pa so prejemali placebo, dokler se simptomi shizofrenije niso ponovili.
English: Following administration of lurasidone, the elimination half-life was 20-40 hours.
Slovenian: Razpolovni čas izločanja lurasidona je od 20 so 40 ur.
English: It is used to treat symptoms of schizophrenia in adults aged 18 years or over.
Slovenian: Uporabljamo ga za zdravljenje simptomov shizofrenije pri odraslih, starih 18 let in starejših.
English: Overall, lurasidone had a negligible effect on weight and other metabolic parameters including total cholesterol, triglycerides, and glucose levels.
Slovenian: Na splošno je lurasidon imel zanemarljiv učinek na telesno maso in druge presnovne parametre, vključno s skupnim holesterolom, trigliceridi in glukozo.
English: Swallow your tablet(s) whole with water, in order to mask the bitter taste.
Slovenian: Tableto (tablete) pogoltnite celo (cele) skupaj z vodo, da se prikrije njihov grenek okus.
English: The maximum daily dose in moderate hepatic impairment patients should not exceed 74 mg and in severe hepatic impairment patients should not exceed 37 mg once daily.
Slovenian: Pri bolnikih z zmerno okvaro jeter največji dnevni odmerek ne sme preseči 74 mg enkrat na dan, pri bolnikih s hudo okvaro jeter pa največji dnevni odmerek ne sme preseči 37 mg enkrat na dan.
English: You should be aware that these conditions may be caused by this medicine
Slovenian: Ta stanja lahko povzroči tudi to zdravilo
English: The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis.
Slovenian: Otopelost bolnika, epileptični napadi ali distonična reakcija glave in vratu po prevelikem odmerku lahko predstavljajo tveganje za aspiracijo po sprožitvi bruhanja.
English: For administration of medicinal products that are substrates of CYP3A4 with a narrow therapeutic range, see section 4.5.
Slovenian: Pri uporabi zdravil, ki so substrati encima CYP3A4 z ozkim terapevtskim indeksom, glejte poglavje 4.5.
English: Latuda contains the active substance lurasidone and belongs to a group of medicines called antipsychotics.
Slovenian: Učinkovina zdravila Latuda je lurasidon, ki spada v skupino zdravil, imenovano antipsihotiki.
English: • lack of energy (lethargy)
Slovenian: • pomanjkanje energije (letargija)
English: • diltiazem (to treat high blood pressure)
Slovenian: • diltiazem (za zdravljenje visokega krvnega tlaka)
English: Do not drink grapefruit juice while you are taking this medicine.
Slovenian: Med jemanjem tega zdravila ne smete piti soka grenivke.
English: for placebo.
Slovenian: Placebo
English: Patients were randomized to flexibly dosed lurasidone 18-74 mg once daily or placebo.
Slovenian: Bolnike so randomizirali na prejemanje prilagodljivega odmerka lurasidona od 18 do 74 mg enkrat dnevno ali na prejemanje placeba.
English: Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, difficulty swallowing, difficulty breathing, and/or protrusion of the tongue.
Slovenian: Distonični simptomi vključujejo: krč mišic vratu, ki včasih lahko napreduje do stiskanja v žrelu, težave pri požiranju, težko dihanje in/ali protruzijo jezika.
English: • A serious blistering rash affecting the skin, mouth, eyes and genitals (Stevens-Johnson syndrome)
Slovenian: • hudi mehurji z izpuščaji, ki prizadenejo kožo, usta, oči in spolovila (Stevens-Johnsonov sindrom).
English: However, an increase in exposure in elderly subjects may be expected for patients if they have impaired renal or hepatic function.
Slovenian: Vendar pa lahko pri starostnikih pričakujemo večjo izpostavljenost v primeru okvare delovanja ledvic ali jeter.
English: Lurasidone is not subject to active uptake transport by OATP1B1 or OATP1B3.
Slovenian: Lurasidon ni substrat za aktivni prenos z OATP1B1 in OATP1B3.
English: Patients should be counseled on signs and symptoms of elevated prolactin, such as gynecomastia, galactorrhea, amenorrhea and erectile dysfunction.
Slovenian: Bolnike je treba seznaniti z znaki in simptomi zvišanih vrednosti prolaktina, kot so ginekomastija, galaktoreja, amenoreja in erektilna disfunkcija.
English: Concomitant administration of BCRP substrates may result in increases in the plasma concentrations of these substrates.
Slovenian: Pri sočasni uporabi substratov za BCRP se koncentracije teh substratov v plazmi lahko povečajo.
English: Based on in vitro studies utilising human liver enzymes, lurasidone is not a substrate for CYP1A2; smoking should, therefore, not have an effect on the pharmacokinetics of lurasidone.
Slovenian: Na osnovi študij in vitro na človeških jetrnih encimih lurasidon ni substrat za CYP1A2, zato kajenje ne vpliva na farmakokinetiko lurasidona.
English: CYP3A4 is the major enzyme responsible for metabolism of the active metabolite ID-14283.
Slovenian: CYP3A4 je glavni encim, odgovoren za presnovo do aktivnega presnovka ID-14283.
English: The use of an immediate release formulation of diltiazem could result in a larger increase in lurasidone exposure.
Slovenian: Pri uporabi diltiazema v obliki s takojšnjim sproščanjem je povečanje izpostavljenosti lurasidonu lahko še večje.
English: The concomitant administration of lurasidone and grapefruit juice has not been assessed.
Slovenian: Sočasne uporabe lurasidona in soka grenivke niso raziskovali.
English: Therefore, lurasidone can be coadministered with oral contraceptives.
Slovenian: Lurasidon se lahko uporablja skupaj s peroralnimi kontraceptivi.
English: Hyperhidrosis Angioedema Stevens-Johnson syndrome
Slovenian: Stevens-Johnsonov sindrom
English: Coadministration of lurasidone with digoxin (a P-gp substrate) did not increase the exposure to digoxin and only slightly increased Cmax (1.3 -fold) and therefore, it is considered that lurasidone can be coadministered with digoxin.
Slovenian: Pri sočasni uporabi lurasidona z digoksinom (substrat za P-gp) se izpostavljenost digoksinu ni povečala, nekoliko se je povečala le Cmax (1,3-krat), zato se lurasidon lahko uporablja sočasno z digoksinom.
English: (b) Lurasidone doses of 18.5, 37, 55.5, 74 mg are equivalent to 20, 40, 60 and 80 amounts of lurasidone hydrochloride.
Slovenian: (b) Odmerki lurasidona po 18,5, 37, 55,5 in 74 mg so enakovredni lurasidonijevemu kloridu v odmerkih po 20, 40, 60 in 80 mg.
English: • low blood levels of sodium which can cause tiredness and confusion, muscle twitching, fits and coma (hyponatremia).
Slovenian: • nizke ravni natrija v krvi, ki lahko povzročijo utrujenost in zmedenost, trzanje mišic, napadi krčev in komo (hiponatriemija)
English: • Parkinson's disease or dementia
Slovenian: • če imate Parkinsonovo bolezen ali demenco
English: • reduced levels of white blood cells (which fight infection) and red blood cells (which carry oxygen around the body)
Slovenian: • zmanjšanje števila belih krvnih celic (ki sodelujejo v boju proti okužbam) in rdečih krvnih celic
English: The occurrence of suicidal behaviour is inherent in psychotic illnesses and in some cases has been reported early after initiation or switch of antipsychotic therapy.
Slovenian: V nekaterih primerih so o njegovem pojavu poročali zgodaj po uvedbi ali zamenjavi antipsihotičnega zdravljenja.
English: Lurasidone doses ranging from 9 to 74 mg administered to healthy subjects produced a dose-dependent reduction in the binding of 11C-raclopride, a D2/D3 receptor ligand, in the caudate, putamen and ventral striatum detected by positron emission tomography.
Slovenian: Odmerki lurasidona od 9 do 74 mg so pri zdravih prostovoljcih povzročili od odmerka odvisno zmanjšanje vezave 11C-rakloprida, liganda za receptorje D2/D3, v kavdatnem jedru, putamenu in ventralnem striatumu, kar je bilo ugotovljeno s pozitronsko emisijsko tomografijo.
English: The mechanism of action of the minor active metabolite of lurasidone ID-14283 is similar to that of lurasidone.
Slovenian: Mehanizem delovanja manjšega aktivnega presnovka lurasidona, ID-14283, je podoben mehanizmu delovanja lurasidona.
English: You may experience sleepiness, tiredness, abnormal body movements, problems with standing and walking, dizziness from low blood pressure, and abnormal heart beats.
Slovenian: Pojavijo se lahko zaspanost, utrujenost, nenormalni telesni gibi, težave s stanjem in hojo, omotica zaradi nizkega krvnega tlaka in nenormalen srčni utrip.
English: Latuda is indicated for the treatment of schizophrenia in adults aged 18 years and over.
Slovenian: Zdravilo Latuda je indicirano za zdravljenje shizofrenije pri odraslih, starih 18 let in starejših.
English: Lurasidone reaches peak serum concentrations in approximately 1-3 hours.
Slovenian: Najvišje koncentracije lurasidona v serumu so dosežene približno v 1 do 3 urah.
English: ΠΑΡΑΓΩΓΗΣ & ΕΜΠΟΡΙΑΣ ΦΑΡΜΑΚΩΝ Aχαίας 4 & Τροιζηνίας GR-14564 Νέα Κηφισιά Τηλ: + 30 210 626 9200
Slovenian: ANGELINI PHARMA HELLAS ABEE ΠΑΡΑΓΩΓΗΣ & ΕΜΠΟΡΙΑΣ ΦΑΡΜΑΚΩΝ Aχαίας 4 & Τροιζηνίας GR-14564 Νέα Κηφισιά Τηλ: + 30 210 626 9200 info@angelinipharma.gr
English: Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with lurasidone and preventive measures undertaken.
Slovenian: Ker imajo bolniki, ki se zdravijo z antipsihotiki, pogosto pridobljene dejavnike tveganja za vensko trombembolijo, je pred uvedbo zdravljenja in med zdravljenjem z lurasidonom treba ugotoviti vse možne dejavnike tveganja za vensko trombembolijo in uvesti preventivne ukrepe.
English: Cardiovascular disorders/QT prolongation
Slovenian: Bolezni srca in ožilja/podaljšanje intervala Q-T
English: If you notice any of these symptoms seek medical advice immediately.
Slovenian: Če opazite katerega koli od teh simptomov, nemudoma poiščite zdravniško pomoč.
English: Ancona (AN), Italy Millmount Healthcare Ltd.
Slovenian: Millmount Healthcare Ltd.
English: The efficacy of lurasidone in the treatment of schizophrenia was demonstrated in five multi-centre, placebo-controlled, double-blind, 6-week trials in subjects who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for schizophrenia.
Slovenian: Učinkovitost lurasidona pri zdravljenju shizofrenije je bila dokazana v petih multicentričnih, s placebom nadzorovanih, dvojno slepih, 6-tedenskih preskušanjih pri osebah, ki so izpolnjevale kriterije za shizofrenijo po DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth
English: • Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing.
Slovenian: • krvni strdki v venah, še posebej v venah nog (simptomi vključujejo otekanje, bolečino in rdečino prizadete noge), ki po žilah lahko potujejo v pljuča in povzročijo bolečino v prsnem košu in težave z dihanjem.
English: These reactions are seen rarely (may affect up to 1 in 1,000 people).
Slovenian: Te reakcije so opazili redko (pojavijo se lahko pri največ 1 od 1.000 bolnikov).
English: It is not known whether lurasidone or its metabolites are excreted in human milk.
Slovenian: Ni znano, če se lurasidon ali njegovi presnovki izločajo v materino mleko.
English: Lurasidone works by blocking receptors in the brain to which the substances dopamine and serotonin attach.
Slovenian: Lurasidon deluje tako, da zavira receptorje v možganih, na katere se vežeta dopamin in serotonin.
English: The short-term efficacy of lurasidone was studied in a 6-week multicentre, randomized, double-blind, placebo-controlled, study of children and adolescent patients (10-17 years of age) who met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for a major depressive episode associated with bipolar I disorder, with or without rapid cycling, and without psychotic features (N=350).
Slovenian: Kratkoročno učinkovitost lurasidona so proučevali v 6-tedenski multicentrični, randomizirani, dvojno slepi, s placebom nadzorovani študiji pri otrocih in mladostnikih (starih od 10 do 17 let), ki so izpolnjevali kriterije pete izdaje diagnostičnega in statističnega priročnika za osebnostne motnje za hudo epizodo depresije (DSM-V), povezane z bipolarno motnjo tipa I, s hitrim cikličnim potekom ali brez in brez psihotičnih simptomov (N = 350).
English: Lurasidone was excreted in milk of rats during lactation (see section 5.3).
Slovenian: Lurasidon se izloča v mleko podgan (glejte poglavje 5.3).
English: If you take more of this medicine than you should, contact your doctor immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Latuda, kot bi smeli Če ste vzeli večji odmerek tega zdravila, kot bi smeli, se nemudoma posvetujte z zdravnikom.
English: It also blocks α2c-adrenergic receptors and α2a-adrenergic receptors with a binding affinity of 10.8 and 40.7 nM respectively.
Slovenian: Prav tako blokira α2c-adrenergične receptorje (vezavna afiniteta: 10,8 nM) in α2a adrenergične receptorje (vezavna afiniteta: 40,7 nM).
English: Mannitol (E 421) Starch, pregelatinised Croscarmellose sodium (E468)
Slovenian: Jedro manitol (E421) predgelirani škrob premreženi natrijev karmelozat (E468)
English: • muscle spasms and stiffness
Slovenian: • mišični krči in okorelost
English: It may take several days or even weeks before this medicine will have a full effect.
Slovenian: Popolni učinek tega zdravila se lahko pojavi šele po nekaj dnevih ali celo tednih zdravljenja.
English: Placebo-adjusted LS mean change (95% CI) from Baseline to Week 6 LOCF in CDRS-R total score for the lurasidone group was -1.8 (-5.6, 2.0) for subjects in the 10- to 14year-old age patients and was -8.6 (-12.4, -4.8) for subjects in the 15- to 17-year-old age patients.
Slovenian: Placebu prilagojena srednja sprememba (95 % interval zaupanja) od izhodiščne vrednosti do 6. tedna zadnjega ocenjevanja (LOCF) je glede na skupne vrednosti CDRS-R v skupini, ki je prejemala lurasidon, znašala -1,8 (-5,6, 2,0) pri bolnikih, starih od 10 do 14 let, in -8,6 (-12,4, -4,8) pri bolnikih, starih od 15 do 17 let.
English: • heart disease or heart disease treatment that makes you prone to low blood pressure or have a family history of irregular heart beat (including QT prolongation)
Slovenian: • če imate bolezen srca ali se zaradi bolezni srca zdravite z zdravili, ki lahko znižajo krvni tlak, ali ima (je imel) kdo od vaših krvnih sorodnikov motnje srčnega ritma (vključno s podaljšanjem intervala Q-T.
English: Angelini Farmacéutica S.A. C. Osi, 7
Slovenian: Spain/ España Angelini Farmacéutica S.A. C. Osi, 7
English: Hypromellose 2910 (E 464) Magnesium stearate (E 470b)
Slovenian: hipromeloza 2910 (E464) magnezijev stearat (E470b)
English: Lurasidone was non-inferior to quetiapine extended release in time to relapse of schizophrenia.
Slovenian: Lurasidon je bil ne-inferioren v primerjavi s kvetiapinom s podaljšanim sproščanjem v času do ponovitve shizofrenije.
English: Lurasidone had a small increase from baseline to Month 12 in body weight and body mass index (Mean (SD): 0.73 (3.36) kg and 0.28 (1.17) kg/m2, respectively) compared to quetiapine extended release (1.23 (4.56) kg and 0.45 (1.63) kg/m2, respectively).
Slovenian: Povečanje telesne mase in indeksa telesne mase od izhodišča do 12. meseca je bilo pri uporabi lurasidona manjše (srednja vrednost (SD): 0,73 (3,36) kg oziroma 0,28 (1,17) kg/m2) v primerjavi s kvetiapinom s podaljšanim sproščanjem (1,23 (4,56) kg 0,45 (1,63) kg/m2).
English: Lurasidone was not genotoxic in a battery of tests.
Slovenian: Lurasidon pri številnih testih ni bil genotoksičen.
English: Gastric lavage (after intubation if patient is unconscious) and administration of activated charcoal together with a laxative should be considered.
Slovenian: Razmisliti je treba o izpiranju želodca (po intubaciji, če je bolnik nezavesten) ter dajanju aktivnega oglja skupaj z odvajalom.
English: What Latuda looks like and contents of the pack
Slovenian: Izgled zdravila Latuda in vsebina pakiranja
English: If you stop taking Latuda
Slovenian: Če ste prenehali jemati zdravilo Latuda
English: Lurasidone is metabolised mainly via CYP3A4.
Slovenian: Lurasidon se predvsem presnavlja s CYP3A4.
English: These effects were due to the hyperprolactinemia following lurasidone treatment, affecting the oestrous cycle and copulatory behaviour as well as the maintenance of corpus luteum of the female rats, resulting in a decrease in implantation and the number of live foetuses.
Slovenian: Ti učinki lurasidona so bili posledica hiperprolaktinemije, ki vpliva tako na estrusni cikel in paritveno vedenje kot vzdrževanje rumenega telesca pri samicah, posledično pa se zmanjša število implantacij in živih plodov.
English: The pharmacokinetics of lurasidone is dose-proportional within a total daily dose range of 18.5 mg to 148 mg. Steady-state concentrations of lurasidone are reached within 7 days of starting lurasidone.
Slovenian: Farmakokinetika lurasidona je sorazmerna z odmerkom v celotnem razponu dnevnih odmerkov od 18,5 mg do 148 mg. Koncentracije lurasidona v stanju dinamičnega ravnovesja so dosežene v 7 dneh po začetku uporabe.
English: Interaction with grapefruit juice Grapefruit juice should be avoided during treatment with lurasidone (see section 4.5).
Slovenian: Med zdravljenjem z lurasidonom se je treba izogibati uživanju soka grenivke (glejte poglavje 4.5).
English: In elderly people with dementia, a small increase in the number of deaths has been reported for patients Reporting of side effects taking medicines for schizophrenia compared with those not receiving these medicines.
Slovenian: Pri starostnikih z demenco, ki so prejemali zdravila za zdravljenje shizofrenije, so poročali o rahlem povečanju števila smrtnih primerov v primerjavi z bolniki, ki niso prejemali teh zdravil.
English: ATC code: N05AE05 Mechanism of action
Slovenian: Farmakoterapevtska skupina: Psiholeptiki, antipsihotiki, oznaka ATC: N05AE05 Mehanizem delovanja
English: In this event, lurasidone should be discontinued.
Slovenian: V tem primeru je treba ukiniti zdravljenje z lurasidonom.
English: • sudden feelings of anxiety
Slovenian: • nenaden občutek tesnobe
English: Talk to your doctor or pharmacist before taking this medicine, or during treatment, especially if you have:
Slovenian: Pred začetkom zdravljenja ali med zdravljenjem se posvetujte z zdravnikom ali s farmacevtom, še posebej:
English: For strong CYP3A4 inhibitors and inducers see section 4.3.
Slovenian: Za močne zaviralce in induktorje CYP3A4 glejte poglavje 4.3.