FrancophonIA/ELRC3.0 huggingface dataset:
English: Your doctor will prescribe Zurampic if your current medicine is not controlling your gout.
Croatian: Vaš liječnik će propisati Zurampic ako lijek koji trenutno uzimate ne kontrolira
English: These are to help prevent or treat the symptoms of gout attacks (a sudden or severe pain and swelling in a joint).
Croatian: Oni će pomoći u sprječavanju ili liječenju simptoma napadaja gihta (iznenadna ili teška bol i oticanje zglobova).
English: The elimination half-life (t½) of lesinurad was approximately 5 hours following a single dose.
Croatian: Poluvijek eliminacije (t½) lesinurada iznosilo je otprilike 5 sati nakon jednokratne doze.
English: There was no apparent influence of the fat content in the meal on the pharmacokinetics of lesinurad.
Croatian: Nije bilo jasnog utjecaja sadržaja masti u obroku na farmakokinetiku lesinurada.
English: Caution should be used when treating these patients with Zurampic.
Croatian: Potreban je oprez prilikom liječenja ovih bolesnika lijekom Zurampic.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Zurampic in all subsets of the paediatric population for the treatment and prevention of hyperuricaemia (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja lijeka Zurampic u svim podskupinama pedijatrijske populacije, za liječenje i prevenciju hiperuricemije (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: As a precautionary measure, it is preferable to avoid the use of Zurampic during pregnancy.
Croatian: Kao mjera opreza, poželjno je izbjegavati primjenu lijeka Zurampic tijekom trudnoće.
English: Effect on cardiac repolarisation
Croatian: Učinak na repolarizaciju srca
English: Your doctor may ask you to have tests to check how your kidneys are working.
Croatian: Vaš liječnik Vas može tražiti da obavite pretrage kako bi provjerio rad Vaših bubrega.
English: Renal clearance is 25.6 mL/min (CV=56%).
Croatian: Bubrežni klirens je 25,6 ml/min (CV = 56%).
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajem netolerancije galaktoze, nedostatkom laktaze ili malapsorpcijom glukoze-galaktoze ne smiju uzimati ovaj lijek.
English: Other medicines and Zurampic
Croatian: Drugi lijekovi i Zurampic
English: Zurampic should not be used as monotherapy or at doses above the recommended dose.
Croatian: Zurampic se ne smije primjenjivati kao monoterapija ili u dozama višima od preporučene.
English: Excipient with known effect: Each tablet contains 52.92 mg of lactose (as monohydrate).
Croatian: Pomoćna tvar s poznatim učinkom: Svaka tableta sadrži 52,92 mg laktoze (u obliku hidrata).
English: Cmax and AUC exposures of lesinurad increased proportionally with single doses of lesinurad from 5 to 1,200 mg.
Croatian: Izloženosti lesinuradu (Cmax i AUC) povećavale su se proporcionalno jednokratnoj dozi lesinurada od 5 do 1200 mg.
English: Zurampic tablets contain lactose (a type of sugar).
Croatian: Zurampic tablete sadrže laktozu (vrsta šećera).
English: Tell your doctor before taking Zurampic if you have or have had heart failure or other heart problems.
Croatian: Prije nego uzmete lijek Zurampic, obavijestite svog liječnika ako imate ili ste imali zatajenje srca ili druge probleme sa srcem.
English: Testing for the target serum uric acid level may be performed as early as 4 weeks after initiating Zurampic treatment.
Croatian: Testiranje za ciljnu razinu mokraćne kiseline u serumu može se provesti već 4 tjedna nakon početka liječenja lijekom Zurampic.
English: Patients with serum creatinine elevations to greater than 1.5 times the pre-treatment value should be closely monitored.
Croatian: Bolesnike u kojih je povišenje serumskog kreatinina veće od 1,5 puta u odnosu na vrijednost prije liječenja treba pomno pratiti.
English: Your doctor may consider stopping Zurampic if your blood tests indicate changes in how your kidneys are working (blood creatinine levels increase) or if you experience symptoms of kidney problems.
Croatian: Vaš liječnik može razmotriti prekid primjene lijeka Zurampic ako Vaše krvne pretrage ukažu na promjene u radu Vaših bubrega (povišene razine kreatinina u krvi) ili ako osjetite simptome problema s bubrezima.
English: Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3).
Croatian: Ispitivanja na životinjama nisu ukazala na izravne ili neizravne štetne učinke s obzirom na reproduktivnu toksičnost (vidjeti dio 5.3).
English: This is because Zurampic can affect the way some other medicines work.
Croatian: To je potrebno jer Zurampic može utjecati na način na koji neki lijekovi djeluju.
English: Non-interventional post-authorisation safety study (PASS): In order to investigate the cardiovascular risk in association with lesinurad exposure, mainly in patients with a history of cardiovascular disorders, the MAH shall conduct and submit the results of an observational prospective study according to an agreed protocol.
Croatian: Neintervencijsko ispitivanje sigurnosti primjene lijeka nakon dobivanja odobrenja za stavljanje lijeka u promet (PASS): kako bi istražio kardiovaskularni rizik povezan s izloženosti lesinuradu, uglavnom u bolesnika s anamnezom kardiovaskularnih poremećaja, nositelj odobrenja će provesti opservacijsko prospektivno ispitivanje u skladu s dogovorenim protokolom i dostaviti rezultate.
English: Lesinurad is highly protein bound and renal clearance is high (as compared to typical human glomerular filtration rate), indicating that active secretion plays an important role in the renal excretion of lesinurad.
Croatian: Lesinurad je u velikoj mjeri vezan na proteine i bubrežni klirens je visok (u usporedbi s tipičnom brzinom glomerularne filtracije u ljudi), što ukazuje da aktivna sekrecija ima važnu ulogu u izlučivanju lesinurada putem bubrega.
English: Additionally, lesinurad led to a 6-8% decrease in International Normalised Ratio (INR) and Prothrombin Time (PT).
Croatian: Nadalje, lesinurad je doveo do smanjenja međunarodnog normaliziranog omjera (INR, od engl. international normalised ratio) i protrombinskog vremena (PV) od 6 - 8%.
English: Lesinurad has no or negligible influence on the ability to drive and use machines.
Croatian: Lesinurad ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Inhibitors of microsomal Epoxide Hydrolase (mEH) (e.g. valproic acid, valpromide) may interfere with the metabolism of lesinurad.
Croatian: Inhibitori mikrosomalne epoksid hidrolaze (mEH) (npr. valproatna kiselina, valpromid) mogu utjecati na metabolizam lesinurada.
English: Other moderate CYP2C9 inhibitors, such as amiodarone, would also be expected to affect lesinurad pharmacokinetics to a similar degree.
Croatian: Očekuje se da će i drugi umjereni inhibitori CYP2C9, poput amiodarona, također utjecati na farmakokinetiku lesinurada u sličnoj mjeri.
English: No dose adjustment is necessary based on age (see section 5.2); however, elderly patients are more likely to have decreased renal function (see dosing recommendations for renal impairment).
Croatian: Nije potrebna prilagodba doze ovisno o dobi (vidjeti dio 5.2); međutim, veća je vjerojatnost da će stariji bolesnici imati smanjenu funkciju bubrega (vidjeti preporuke za doziranje kod oštećenja funkcije bubrega).
English: Data from the long-term extension studies until 24 months revealed a renal safety profile consistent with that observed in the placebocontrolled studies.
Croatian: Podaci iz dugotrajnih nastavaka ispitivanja do 24 mjeseca pokazali su bubrežni sigurnosni profil dosljedan onom opaženom u placebom kontroliranim ispitivanjima.
English: • At the request of the European Medicines Agency; • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: • Uoči svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je omjer korist/rizik rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili smanjenja rizika.
English: Following administration of a single oral dose of lesinurad in either the fed or fasted state, maximum plasma concentrations (Cmax) were attained within 1 to 4 hours.
Croatian: Nakon primjene jednokratne oralne doze lesinurada, bilo u stanju sitosti ili natašte, maksimalne koncentracije u plazmi (Cmax) postignute su unutar 1 do 4 sata.
English: In vitro assessment of interactions
Croatian: In vitro procjena interakcija
English: Mean plasma-to-blood ratios of lesinurad AUC and Cmax were approximately 1.8, indicating that radioactivity was largely contained in the plasma space and did not penetrate or partition extensively into red blood cells.
Croatian: Srednji omjeri AUC i Cmax lesinurada u plazmi u odnosu na krv bili su otprilike 1,8, što ukazuje da je radioaktivnost uvelike zadržana u plazmi i nije se opsežno proširila ili preraspodijelila u crvene krvne stanice.
English: However, individual values were well within the range observed in the extensive metaboliser subjects.
Croatian: Međutim, pojedine vrijednosti bile su dobrano unutar raspona opaženog u brzih metabolizatora.
English: *Photodermatosis, photosensitivity reaction, dermatitis allergic, pruritus and urticaria.
Croatian: *Fotodermatoza, reakcija fotoosjetljivosti, alergijski dermatitis, pruritus i urtikarija.
English: Based on in vitro data, lesinurad may be a mild inducer of CYP2B6 but this interaction has not been studied clinically.
Croatian: Na temelju in vitro podataka, lesinurad može biti blagi induktor CYP2B6, ali ova interakcija nije klinički ispitana.
English: Within 7 days following single dosing of radiolabelled lesinurad, 63% of administered radioactive dose was recovered in urine and 32% of administered radioactive dose was recovered in faeces.
Croatian: Unutar 7 dana nakon jednokratne doze radioaktivno obilježenog lesinurada, 63% primijenjene radioaktivne doze bilo je nađeno u mokraći, a 32% primijenjene radioaktivne doze bilo je nađeno u stolici.
English: By lowering the amount of uric acid in the blood, Zurampic stops this accumulation and may prevent further joint damage.
Croatian: Sniženjem količine mokraćne kiseline u krvi, Zurampic zaustavlja to nakupljanje i može spriječiti daljnje oštećenje zglobova.
English: You should avoid taking Zurampic during pregnancy or if you are breast-feeding.
Croatian: Trebate izbjegavati uzimanje lijeka Zurampic tijekom trudnoće ili dojenja.
English: Time from Baseline in Months
Croatian: Vrijeme od početka ispitivanja u mjesecima
English: URAT1 is responsible for the majority of the reabsorption of filtered uric acid from the renal tubular lumen.
Croatian: URAT1 je odgovoran za većinu ponovne apsorpcije filtrirane mokraćne kiseline iz lumena bubrežnih kanalića.
English: Zurampic may cause serious kidney problems (see section 4), which occur more frequently if Zurampic is taken alone (see section 3).
Croatian: Zurampic može uzrokovati ozbiljne probleme s bubrezima (vidjeti dio 4), koji mogu biti češći ako se Zurampic uzima sam (vidjeti dio 3).
English: injections, patches and implants - rifampin - to treat tuberculosis - warfarin - to prevent and treat blood clots forming in the legs, lungs, brain and heart.
Croatian: „pilule“), injekcije, naljepke (flastere) i implantate - rifampicin -za liječenje tuberkuloze - varfarin -za sprječavanje i liječenje nastanka krvnih ugrušaka u nogama, plućima, mozgu i srcu.
English: BLISTER NON-PERFORATED (10 TABLETS) BLISTER PERFORATED UNIT DOSE CALENDAR BLISTER (14 TABLETS)
Croatian: NEPERFORIRANI BLISTER (10 TABLETA) PERFORIRANI BLISTER S JEDINIČNIM DOZAMA KALENDARSKI BLISTER (14 TABLETA)
English: Children and adolescents Zurampic is not recommended for use in children and adolescents below 18 years of age.
Croatian: Ne preporučuje se primjena lijeka Zurampic u djece i adolescenata mlađih od 18 godina.
English: Do not use this medicine after the expiry date which is stated on the carton or blister foil after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake „Rok valjanosti“ ili foliji blistera iza oznake „EXP“.
English: If you take more Zurampic than you should If you take more of this medicine than you should, talk to a doctor or go to the nearest hospital.
Croatian: Ako uzmete više ovog lijeka nego što ste trebali obavijestite svog liječnika ili otiđite u najbližu bolnicu.
English: Zurampic must never be taken without a ‘xanthine oxidase inhibitor' medicine.
Croatian: Zurampic se nikada ne smije uzeti bez inhibitora ksantin oksidaze.
English: Zurampic should be interrupted if serum creatinine is elevated to greater than 2 times the pre-treatment value or in case of an absolute serum creatinine value greater than 4.0 mg/dL.
Croatian: Primjenu lijeka Zurampic treba privremeno prekinuti ako razina serumskog kreatinina poraste više nego dvostruko u odnosu na vrijednost prije početka liječenja ili u slučaju apsolutne vrijednosti serumskog kreatinina veće od 4,0 mg/dl.
English: Based on interaction studies in healthy subjects or gout patients, Zurampic does not have clinically significant interactions with NSAIDs (naproxen and indomethacin), colchicine, repaglinide, tolbutamide, febuxostat or allopurinol.
Croatian: Temeljeno na ispitivanjima interakcija u zdravih ispitanika ili bolesnika s gihtom, Zurampic ne stupa u klinički značajne interakcije s NSAIL-ovima (naproksenom i indometacinom), kolhicinom, repaglinidom, tolbutaminom, febuksostatom ili alopurinolom.
English: Warnings and precautions Talk to your doctor or pharmacist before taking Zurampic.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku ili ljekarniku prije nego uzmete Zurampic.
English: - if you have ‘tumour lysis syndrome' - a fast breakdown of cancer cells which can cause high uric acid levels - if you have ‘Lesch-Nyhan syndrome' -a rare inherited illness that starts in childhood where there is too much uric acid in the blood - if your kidneys work very poorly or you have ‘End-Stage Kidney Disease' - if you have received a kidney transplant - if you are on kidney dialysis.
Croatian: - ako imate „sindrom lize tumora“ - brzi raspad stanica raka koji može uzrokovati visoke razine mokraćne kiseline - ako imate „Lesch-Nyhanovsindrom“-rijetku nasljednu bolest koja počinje u djetinjstvu kada postoji previše mokraćne kiseline u krvi - ako Vaši bubrezi rade jako slabo ili imate „završni stadij bolesti bubrega“ - ako Vam je transplantiran bubreg - ako ste na dijalizi bubrega
English: The recommended dose is 1 tablet of 200 mg once a day in the morning.
Croatian: Preporučena doza je 1 tableta od 200 mg jedanput dnevno ujutro.
English: If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking Zurampic.
Croatian: Ako se bilo što od gore navedenog odnosi na Vas (ili ako niste sigurni), obratite se svom liječniku ili ljekarniku prije nego uzmete Zurampic.
English: Gout is a type of arthritis caused by an accumulation of urate crystals around the joints.
Croatian: Giht je vrsta artritisa uzrokovana nakupljanjem kristala urata u zglobovima.
English: Your doctor may give you other medicines such as ‘colchicine' and ‘nonsteroidal anti-inflammatory drugs (NSAIDs)'.
Croatian: Vaš liječnik Vam može dati druge lijekove, poput kolhicina ili nesteroidnih protuupalnih lijekova.
English: Plasma protein binding is not meaningfully altered in patients with renal or hepatic impairment.
Croatian: Vezanje na proteine u plazmi nije značajno promijenjeno u bolesnika s oštećenjem funkcije bubrega ili jetre.
English: Patients should be informed that failure to follow these instructions may increase the risk of renal events (see section 4.4).
Croatian: Bolesnike treba informirati da nepridržavanje ovih uputa može povećati rizik od bubrežnih događaja (vidjeti dio 4.4).
English: Patients known to be CYP2C9 poor metabolisers should be treated with caution, as the potential risk of renal-related adverse effects may be increased (see sections 4.8 and 5.2).
Croatian: Bolesnike za koje je poznato da su spori CYP2C9 metabolizatori treba liječiti s oprezom, jer mogući rizik od štetnih učinaka povezanih s bubrezima može biti povećan (vidjeti dijelove 4.8 i 5.2).
English: Lesinurad is a mild to moderate inducer of CYP3A and therefore may lower plasma concentrations of some hormonal contraceptives, thereby decreasing contraceptive effectiveness (see sections 4.4 and
Croatian: Lesinurad je blagi do umjereni induktor CYP3A i prema tome može sniziti koncentracije nekih hormonskih kontraceptiva u plazmi te time smanjiti učinkovitost kontracepcije (vidjeti dijelove 4.4 i
English: The lack of an observed interaction could be due to the combination of the induction of CYP2C9 and inhibition of OATP1B1 and 1B3.
Croatian: Izostanak zamijećene interakcije može biti posljedica kombinacije indukcije CYP2C9 i inhibicije OATP1B1 i 1B3.
English: Pack sizes of 10, 28, 30, 98 in non-perforated blisters.
Croatian: Veličine pakiranja od 10, 28, 30, 98 tableta u neperforiranim blisterima.
English: The effect of lesinurad on fertility in humans has not been studied.
Croatian: Nije ispitan učinak lesinurada na plodnost u ljudi.
English: Hormonal contraceptives, including oral, injectable, transdermal, and implantable forms, may not be reliable when Zurampic is co-administered.
Croatian: Hormonski kontraceptivi, uključujući oralne, injekcijske i transdermalne oblike te implantate, mogu biti nepouzdani kada se primjenjuju istodobno s lijekom Zurampic.
English: Available pharmacodynamic/toxicological data in rats have shown excretion of lesinurad in milk.
Croatian: Dostupni farmakodinamički/toksikološki podaci u štakora pokazali su da se lesinurad izlučuje u majčino mlijeko.
English: The safety of Zurampic 200 mg was evaluated in the Phase 3 combination therapy clinical trials (including extension studies).
Croatian: Sigurnost lijeka Zurampic u dozi od 200 mg procijenjena je u kliničkim ispitivanjima kombinirane terapije faze 3 (uključujući nastavke ispitivanja).
English: In patients with tophi or persistent symptoms, the target is less than 5 mg/dL (300 µmol/L).
Croatian: U bolesnika s tofima ili trajnim simptomima, ciljna razina je manje od 5 mg/dl (300 µmol/l).
English: Wait and take your next dose of Zurampic with your next morning dose of allopurinol or febuxostat.
Croatian: Pričekajte i uzmite Vašu sljedeću dozu lijeka Zurampic s Vašom sljedećom jutarnjom dozom alopurinola ili febuksostata.
English: Lesinurad is a mild to moderate inducer of CYP3A (see section 4.5).
Croatian: Lesinurad je blagi do umjereni induktor CYP3A (vidjeti dio 4.5).
English: Your doctor may tell you to restart treatment with Zurampic when your kidney function improves.
Croatian: Vaš liječnik Vam može reći da ponovno počnete uzimati Zurampic kada se poboljša funkcija Vaših bubrega.
English: Based on population pharmacokinetic analysis, age, gender, race and ethnicity do not have a clinically meaningful effect on the pharmacokinetics of lesinurad.
Croatian: S obzirom na analizu populacijske farmakokinetike, ne postoji klinički značajan utjecaj dobi, spola, rase ili etničke pripadnosti na farmakokinetiku lesinurada.
English: Zurampic has not been studied in patients with severe hepatic impairment; therefore, dose recommendations cannot be given.
Croatian: Zurampic nije ispitivan u bolesnika s teškim oštećenjem funkcije jetre; prema tome, ne mogu se dati preporuke za doziranje.
English: Epoxide hydrolase inhibitors
Croatian: Inhibitori epoksid hidrolaze
English: The possibility of reduced efficacy of concomitant medicinal products that are CYP3A substrates should be considered and their efficacy (e.g. blood pressure and cholesterol levels) should be monitored (see section 4.4).
Croatian: Treba uzeti u obzir mogućnost smanjene djelotvornosti istodobno primjenjivanih lijekova koji su supstrati CYP3A te je potrebno pratiti njihovu djelotvornost (npr. krvni tlak i razinu kolesterola) (vidjeti dio 4.4).
English: If you are not sure, talk to your doctor or pharmacist before taking Zurampic.
Croatian: Ako niste sigurni, obratite se svom liječniku ili ljekarniku prije nego uzmete Zurampic.
English: There is no clinical experience in patients with severe (Child-Pugh class C) hepatic impairment.
Croatian: Ne postoji kliničko iskustvo u bolesnika s teškim (Child-Pugh stadij C) oštećenjem funkcije jetre.
English: Renal function should be evaluated prior to initiation of Zurampic and monitored periodically thereafter, e.g. 4 times per year, based on clinical considerations, such as baseline renal function, volume depletion, concurrent illness or concomitant medications.
Croatian: Funkciju bubrega treba procijeniti prije početka primjene lijeka Zurampic, te je redovito pratiti tijekom liječenja, npr. 4 puta godišnje, na temelju kliničkih okolnosti poput početne funkcije bubrega, deplecije volumena, istodobno prisutne bolesti ili istodobno primjenjivanih lijekova.
English: Rifampin
Croatian: Rifampicin
English: Based on these studies, Zurampic is only recommended at a dose of 200 mg once daily in combination with a xanthine oxidase inhibitor (see sections 4.2 and 4.4).
Croatian: Temeljeno na ovim ispitivanjima, Zurampic se preporučuje samo u dozi od 200 mg jedanput dnevno u kombinaciji s inhibitorom ksantin oksidaze (vidjeti dijelove 4.2 i 4.4).
English: In an interaction study conducted in healthy subjects with multiple doses of Zurampic 400 mg and single dose warfarin (25 mg), lesinurad led to a decrease in exposure of R-warfarin (the less active enantiomer) and had no effect on the exposure of S-warfarin (the more active enantiomer).
Croatian: U ispitivanju interakcija provedenom na zdravim ispitanicima uz višestruke doze lijeka Zurampic od 400 mg i jednokratnu dozu varfarina (25 mg), lesinurad je doveo do smanjenja u izloženosti Rvarfarinu (manje aktivan enantiomer) i nije imao učinak na izloženost S-varfarinu (aktivniji enantiomer).
English: Rare - may affect up to 1 in 1000 people - skin reactions, including redness, itchy skin, lumpy rash (hives) and skin rash on exposure to sunshine.
Croatian: Rijetko - mogu se javiti u do 1 na 1000 osoba - kožne reakcije, uključujući crvenilo, svrbež kože, osip s uzdignućima na koži (koprivnjača) i osip na koži nakon izlaganja suncu.
English: Secondary hyperuricaemia
Croatian: Sekundarna hiperuricemija
English: Fluconazole, a moderate CYP2C9 inhibitor, increased lesinurad AUC (56%) and Cmax (38%), as well as the amount of lesinurad excreted unchanged in urine.
Croatian: Flukonazol, umjereni inhibitor CYP2C9, povećao je AUC (56%) i Cmax (38%) lesinurada, kao i količinu nepromijenjenog lesinurada izlučenog u mokraći.
English: Additional monitoring of lipids and blood pressure is recommended in patients using sensitive CYP3A substrate lipid lowering medicines (such as lovastatin or simvastatin) or antihypertensive medicines (such as amlodipine, felodipine or nisoldipine), since their efficacy may be reduced (see section 4.5).
Croatian: Preporučuje se dodatno praćenje lipida i krvnog tlaka u bolesnika koji uzimaju lijekove koji su osjetljivi supstrati CYP3A za sniženje lipida (poput lovastatina ili simvastatina) ili sniženje krvnog tlaka (poput amlodipina, felodipina ili nisoldipina), s obzirom da njihova djelotvornost može biti smanjena (vidjeti dio 4.5).
English: In interaction studies conducted in healthy subjects with Zurampic and CYP3A substrates, lesinurad reduced the plasma concentrations of sildenafil and amlodipine.
Croatian: U ispitivanjima interakcija provedenima na zdravim ispitanicima s lijekom Zurampic i supstratima CYP3A, lesinurad je smanjio koncentracije sildenafila i amlodipina u plazmi.