FrancophonIA/ELRC3.0 huggingface dataset:
English: Lurasidone is an in vitro substrate of the efflux transporters P-gp and BCRP.
Danish: Lurasidon er et in vitro-substrat af effluks-transportørerne P-gp og BCRP.
English: (b) p-values for lurasidone vs. placebo were adjusted for multiple comparisons.
Danish: (b) p-værdier for lurasidon vs. placebo blev justeret for multiple sammenligninger.
English: The serum concentrations of lurasidone are increased in healthy subjects with Child-Pugh Class A, B and C hepatic impairment with an increased exposure of 1.5-, 1.7- and 3-fold respectively.
Danish: Serumkoncentrationerne af lurasidon er øget hos raske forsøgspersoner med Child-Pugh, klasse A, B og C nedsat leverfunktion med en hhv. 1,5-, 1,7- og 3-foldig forøgelse af eksponeringen.
English: Package leaflet: Information for the patient Latuda 18.5 mg film-coated tablets Latuda 37 mg film-coated tablets Latuda 74 mg film-coated tablets lurasidone
Danish: Indlægsseddel:Information til patienten Latuda 18,5 mg, filmovertrukne tabletter Latuda 37 mg, filmovertrukne tabletter Latuda 74 mg, filmovertrukne tabletter lurasidon
English: P-values for olanzapine and quetiapine XR vs. placebo were unadjusted.
Danish: P-værdierne blev ikke justeret for olanzapin og quetiapin XR vs. placebo.
English: Additional signs may include myoglobinuria (rhabdomyolysis) and acute renal failure.
Danish: Yderligere kliniske tegn er bl.a. myoglobinuri (rabdomyolyse) og akut nyresvigt.
English: Lurasidone should be used with caution in elderly patients with dementia who have risk factors for stroke.
Danish: Der bør udvises forsigtighed ved brug af lurasidon hos ældre patienter med demens, som har risikofaktorer for slagtilfælde.
English: • increased blood prolactin, increased blood glucose (blood sugar), increase in some liver enzymes, seen in blood tests
Danish: • øget prolaktin i blodet, øget glukose i blodet (blodsukker), forhøjede leverenzymer, påvises i blodprøver
English: The most common adverse drug reactions (ADRs) (≥ 10%) were akathisia and somnolence, which were dose-related up to
Danish: De mest almindelige bivirkninger (≥ 10 %) var akatisi og somnolens, som var dosisrelaterede op til 111 mg.
English: Grapefruit juice should be avoided during treatment with lurasidone.
Danish: Indtagelsen af grapefrugtjuice skal derfor undgås under behandling med lurasidon.
English: The incidence of akathisia for lurasidone-treated subjects was 12.9% versus 3.0% for placebo-treated subjects.
Danish: Forekomsten af akatisi var 12,9 % for lurasidon-behandlede forsøgspersoner over for 3,0 % for placebobehandlede forsøgspersoner.
English: Alanine aminotransferase increased
Danish: Forhøjet alaninaminotransfe rase
English: • if you are taking some other medicines (see section 2, Other medicines and Latuda)
Danish: • om du tager anden medicin (se pkt.
English: • difficulty sleeping, tiredness, agitation and anxiety
Danish: • Søvnbesvær, træthed, ophidselse og angst.
English: Renal impairment The serum concentrations of lurasidone are increased in healthy subjects with mild, moderate and severe renal impairment with an increased exposure of 1.5, 1.9 and 2.0-fold respectively.
Danish: Serumkoncentrationerne af lurasidon er øget hos raske forsøgspersoner med let, moderat og svært nedsat nyrefunktion med en forøgelse af eksponeringen på hhv. 1,5, 1,9 og 2,0 gange.
English: Lurasidone and its active metabolite ID-14283 both contribute to the pharmacodynamic effect at the dopaminergic and serotonergic receptors.
Danish: Lurasidon og dets aktive metabolit ID-14283 bidrager begge til den farmakodynamiske effekt på dopaminerge og serotonerge receptorer.
English: Lurasidone is an inhibitor of P-gp, BCRP and OCT1 in vitro (see section 4.5).
Danish: Lurasidon er en hæmmer af P-gp, BCRP og OCT1 in vitro (se pkt.
English: Healthcare professionals are asked to report any suspected adverse reactions via the following website: www.mhra.gov.uk/yellowcard.
Danish: Læger og sundhedspersonale anmodes om at rapportere eventuelle formodede bivirkninger via følgende hjemmeside: www.bogbivirkning.dk.
English: Coadministration of lurasidone with medicinal products that moderately inhibit CYP3A4 (e.g. diltiazem, erythromycin, fluconazole verapamil) may increase exposure to lurasidone.
Danish: Samtidig administration af lurasidon og lægemidler, der hæmmer CYP3A4 i moderat grad (f.eks. diltiazem, erythromycin, fluconazol verapamil), kan øge eksponeringen for lurasidon.
English: (a) p-values for lurasidone vs. placebo were adjusted for multiple comparisons.
Danish: (a) p-værdier for lurasidon vs. placebo blev justeret for flere sammenligninger.
English: 14 x 1 film-coated tablets 28 x 1 film-coated tablets 30 x 1 film-coated tablets 56 x 1 film-coated tablets 60 x 1 film-coated tablets 90 x 1 film-coated tablets 98 x 1 film-coated tablets
Danish: 14 x 1 filmovertrukne tabletter 28 x 1 filmovertrukne tabletter 30 x 1 filmovertrukne tabletter 56 x 1 filmovertrukne tabletter 60 x 1 filmovertrukne tabletter 90 x 1 filmovertrukne tabletter 98 x 1 filmovertrukne tabletter
English: Brigittenauer Lände 50-54 1200 Wien
Danish: Angelini Pharma Österreich GmbH Brigittenauer Lände 50-54 1200 Wien
English: It is not known if lurasidone passes into breast milk.
Danish: Det er ukendt, om lurasidon går over i modermælken.
English: • increase in creatinine (a marker of kidney function) seen in blood tests.
Danish: • Forhøjet kreatinin (en markør for nyrefunktion), påvist i blodprøver.
English: 37 mg 74 mg 111 mg 148 mg
Danish: 111 mg 148 mg
English: For administration of medicinal products that are substrates of CYP3A4 with a narrow therapeutic range, see section 4.5.
Danish: For information omkring administration af lægemidler med et smalt terapeutisk vindue, der er substrater for CYP3A4, se pkt.
English: Other medicines and Latuda
Danish: Brug af anden medicin sammen med Latuda
English: • erythromycin (to treat infections)
Danish: • erythromycin (til behandling af infektioner)
English: Coadministration of lurasidone with lithium indicated that lithium had clinically negligible effects on the pharmacokinetics of lurasidone, therefore no dose adjustment of lurasidone is required when coadministered with lithium.
Danish: Samtidig administration af lurasidon og lithium tydede på, at litium kun havde en klinisk ubetydelig indvirkning på lurasidons farmakokinetiske egenskaber, og derfor er en dosisjustering af lurasidon ikke nødvendig, når det administreres samtidig med litium.
English: • slow heart rate
Danish: • langsom hjertefrekvens
English: There were no clinically relevant differences in the pharmacokinetics of lurasidone in a population pharmacokinetic analysis in patients with schizophrenia.
Danish: Der var ingen klinisk relevante forskelle i de farmakokinetiske egenskaber for lurasidon i en populationsfarmakokinetisk analyse af patienter med skizofreni.
English: The maximum daily dose in moderate hepatic impairment patients should not exceed 74 mg and in severe hepatic impairment patients should not exceed 37 mg once daily.
Danish: Den maksimale dosis til patienter med moderat nedsat leverfunktion må ikke overstige 74 mg én gang dagligt, og 37 mg én gang dagligt for patienter med alvorligt nedsat leverfunktion.
English: Placebo-adjusted LS mean change (95% CI) from Baseline to Week 6 LOCF in CDRS-R total score for the lurasidone group was -1.8 (-5.6, 2.0) for subjects in the 10- to 14year-old age patients and was -8.6 (-12.4, -4.8) for subjects in the 15- to 17-year-old age patients.
Danish: Placebojusteret gennemsnitlig LS-ændring (95 % CI) fra baseline til uge 6 LOCF i CDRS-R samlet score for lurasidon-gruppen var -1,8 (-5,6, 2,0) for deltagere i 10-14 års alderen og var -8,6 (-12,4, -4,8) for deltagere i 15-17 års alderen.
English: Medicinal products with dopamine receptor antagonistic properties have been associated with extrapyramidal adverse reactions including rigidity, tremors, mask-like face, dystonias, drooling of saliva, drooped posture and abnormal gait.
Danish: Lægemidler med dopaminreceptor-antagonistiske egenskaber er blevet forbundet med ekstrapyramidale bivirkninger, herunder stivhed, rystelser, maskeagtigt ansigt, dystonier, savlen, hængende kropsholdning og abnorm gangart.
English: The following terms and frequencies are applied: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1000 to < 1/100), rare (≥ 1/10,000 to < 1/1000), very rare (<1 /10,000) and not known (cannot be estimated from the available data).
Danish: (≥1/10), almindelig (≥1/100 til <1/10), ikke almindelig (≥1/1.000 til <1/100), sjælden (≥1/10.000 til
English: Lurasidone should be used cautiously in patients with a history of seizures or other conditions that potentially lower the seizure threshold.
Danish: Lurasidon bør anvendes med forsigtighed til patienter med tidligere krampeanfald eller andre tilstande, som potentielt sænker krampetærsklen.
English: Caution should be exercised when lurasidone is prescribed in patients with known cardiovascular disease or family history of QT prolongation, hypokalaemia, and in concomitant use with other medicinal products thought to prolong the QT interval.
Danish: Som ved andre antipsykotiske lægemidler bør der udvises forsigtighed, når lurasidon ordineres til patienter med kendt hjertekarsygdom eller familiær disposition til forlængelse af QT-intervallet, hyperkalæmi og ved samtidig brug af andre lægemidler, som menes at forlænge QT-intervallet.
English: It is not known whether lurasidone or its metabolites are excreted in human milk.
Danish: Det er ukendt, om lurasidon/metabolitter udskilles i human mælk.
English: In a dose range finding study in pregnant rats, 150 mg/kg/day lurasidone hydrochloride caused fetal growth retardation without signs of teratogenicity.
Danish: I et studie af dosisområder med drægtige rotter medførte 150 mg/kg/dag lurasidonhydrochlorid føtal vækstretardering uden tegn på teratogenicitet.
English: Cartons contain 14 x 1, 28 x 1, 30 x 1, 56 x 1, 60 x 1, 90 x 1 or 98 x 1 tablets in aluminium/aluminium perforated unit dose blisters.
Danish: Pakningen indeholder:14 x 1, 28 x 1, 30 x 1, 56 x 1, 60 x 1, 90 x 1 eller 98 x 1 filmovertrukne tabletter i aluminium/aluminium-perforerede enkeltdosisblistre.
English: A fertility study in female rats resulted in prolonged oestrous cycle and delayed copulation at ≥1.5 mg/kg/day lurasidone hydrochloride, whilst the copulation and fertility indices, and the numbers of corpora lutea, implantations and live foetuses were decreased at 150 mg/kg/day lurasidone hydrochloride.
Danish: I et fertilitetsforsøg med hunrotter var der abnorm brunstcyklus og forsinket parring ≥1,5 mg/kg/dag lurasidonhydrochlorid, mens parring, fertilitetsindeks og antal af corpora lutea, implantationer og levende fostre var reduceret ved 150 mg/kg/dag lurasidonhydrochlorid.
English: Lurasidone is a substrate of P-gp and BCRP in vitro and the in vivo relevance of this is unclear.
Danish: Lurasidon er et substrat for P-gp og BCRP in vitro og in vivo, relevansen af dette er uklar.
English: • nafcillin (to treat infections)
Danish: • nafcillin (til behandling af infektioner)
English: Coadministration of lurasidone with P-gp and BCRP inhibitors may increase exposure to lurasidone.
Danish: Samtidig administration af lurasidon og P-gp- og BCRP-hæmmere kan øge eksponeringen af lurasidon.
English: Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, difficulty swallowing, difficulty breathing, and/or protrusion of the tongue.
Danish: Dystoniske symptomer, herunder:kramper i halsmuskulaturen, der sommetider forværres til tæthed i halsen, herunder synkebesvær, åndedrætsbesvær og/eller fremstikkende tunge.
English: There were no clinically relevant differences between genders in the pharmacokinetics of lurasidone in a population pharmacokinetic analysis in patients with schizophrenia.
Danish: Der var ingen klinisk relevante forskelle mellem kønnene mht. de farmakokinetiske egenskaber for lurasidon i en populationsfarmakokinetisk analyse af patienter med skizofreni.
English: Breast feeding in women receiving lurasidone should be considered only if the potential benefit of treatment justifies the potential risk to the child.
Danish: Kvinder, der tager lurasidon, bør kun amme, hvis de potentielle fordele ved behandlingen, opvejer den potentielle risiko for det ammede barn.
English: • increase in creatine phosphokinase (an enzyme in muscles) seen in blood tests
Danish: • Forhøjet kreatininfosfokinase (et enzym i musklerne) påvist i blodprøver
English: Decreased appetite Blood glucose increased Hyponatraemia
Danish: Nedsat appetit Forhøjet blodsukker Hyponatriæmi
English: If your baby develops any of these symptoms you should contact your doctor.
Danish: Skulle dit barn få nogle af disse bivirkninger, skal du straks kontakte lægen.
English: • blood pressure dropping upon your standing up which may cause fainting.
Danish: • oplever blodtryksfald, når du rejser dig op, som kan føre til besvimelse.
English: If you notice any of the following symptoms seek medical attention immediately:
Danish: Hvis du udvikler et eller flere af disse symptomer, skal du omgående søge lægehjælp:
English: Moderate CYP3A4 inhibitors are estimated to result in a 2-5-fold increase in exposure of CYP3A4 substrates.
Danish: Moderate CYP3A4-hæmmere er estimeret til at medføre en 2-5-foldig øgning i eksponeringen for CYP3A4-substrater.
English: Coadministration of lurasidone with midazolam, a sensitive CYP3A4 substrate, resulted in a < 1.5-fold increase in midazolam exposure.
Danish: Samtidig administration af lurasidon med midazolam, et følsomt CYP3A4-substrat, medførte en <1,5-foldig øgning i eksponeringen for midazolam.
English: Hyperhidrosis Angioedema Stevens-Johnson syndrome
Danish: StevensJohnsons syndrom
English: Stamullen, Co. Meath, K32 YD60,
Danish: Millmount Healthcare Ltd. Block-7, City North Business Campus, Stamullen, Co. Meath, K32 YD60, Irland
English: D1050233.
Danish: Studie D1050229
English: Breast enlargement**** Breast pain**** Galactorrhoea**** Erectile dysfunction**** Amenorrhoea**** Dysmenorrhoea****
Danish: Smerter i brystet**** Galaktorré**** Erektil dysfunktion**** Amenorré**** Dysmenoré****
English: • blood pressure dropping upon standing up which may cause fainting
Danish: • blodtryksfald ved rejsning til stående stilling, som kan medføre besvimelse
English: • are taking medicines which may affect the level of lurasidone in your blood such as: medicines for fungal infections such as itraconazole, ketoconazole (except as a shampoo), posaconazole or voriconazole medicines for an infection such as the antibiotic clarithromycin or telithromycin medicines for HIV infections such as cobicistat, indinavir, nelfinavir, ritonavir, and saquinavir boceprevir, and telaprevir (medicines for chronic hepatitis) nefazodone (a medicine for depression) rifampicin (a medicine for tuberculosis) carbamazepine, phenobarbital and phenytoin (medicines for seizures) St John's wort (Hypericum perforatum) (herbal medicine for depression).
Danish: • tager lægemidler, som påvirker niveauet af lurasidon i blodet såsom: medicin mod svampeinfektioner, såsom itraconazol, ketoconazol (undtagen i shampoo) posaconazol eller voriconazol medicin mod en infektion, såsom antibiotisk clarithromycin eller telithromycin medicin mod HIV-infektioner, såsom cobicistat, indinaivir, nelfinavir, ritonavir og saquinavir boceprevir og telaprevir (medicin mod kronisk hepatitis) nefazodon (et lægemiddel mod depression) rifampicin (et lægemiddel mod tuberkulose) carbamazepin, phenobarbital og phenytoin (medicin mod krampeanfald) Hyperikum (Hypericum perforatum) (urtemedicin mod depression).
English: Lurasidone and its active metabolite ID-14283 are primarily metabolised by CYP3A4.
Danish: Lurasidon og dens aktive metabolit ID-14283metaboliseres primært af CYP3A4.
English: Caution is advised when prescribing lurasidone with medicinal products known to prolong the QT interval, e.g. class IA antiarrhythmics (e.g. quinidine, disopyramide) and class III antiarrhythmics (e.g. amiodarone, sotalol), some antihistaminics, some other antipsychotics and some antimalarials (e.g. mefloquine).
Danish: Der tilrådes forsigtighed ved ordinering af lurasidon sammen med lægemidler, som vides at forlænge QT-intervallet, f.eks. antiarytmika af klasse IA (f.eks. kinidin, disopyramid) og antiarytmika af klasse III (f.eks. amiodaron, sotalol), visse antihistaminer, visse andre antipsykotika, og visse malariamidler (f.eks. mefloquin).
English: Rome - Italy
Danish: Rom - Italien
English: • decreased liver function
Danish: • har nedsat leverfunktion.
English: • muscle spasms and stiffness
Danish: • Muskelspasmer og -stivhed.
English: Lurasidone was not teratogenic in rats or rabbits at an exposure similar to or below the maximum recommended human dose (148 mg lurasidone ).
Danish: Lurasidon var ikke teratogent i rotter eller kaniner ved en eksponering svarende til, eller under, den maksimalt anbefalede dosis til mennesker.
English: Coadministration of lurasidone with the strong CYP3A4 inhibitor ketoconazole resulted in a 9- and 6-fold increase in exposure of lurasidone and its active metabolite ID-14283 respectively.
Danish: Samtidig administration af lurasidon med den kraftige CYP3A4-hæmmer ketoconazol medførte en 9- og 6-foldig øgning i eksponeringen for hhv. lurasidon og dens aktive metabolit ID-14283.
English: • Parkinsonism: This is a medical term that describes many symptoms which include increase in saliva secretion or watery mouth, drooling, jerks when bending the limbs, slow, reduced or impaired body movements, no expression in the face, muscle tightness, stiff neck, muscle stiffness, small, shuffling, hurried steps and lack of normal arm movements when walking, persistent blinking in response to tapping of the forehead (an abnormal reflex)
Danish: • Parkinsonisme:Dette er en medicinsk betegnelse, der beskriver mange symptomer på en gang og omfatter øget spytproduktion, savlen, spjæt, når arme og ben bøjes, langsomme, nedsatte eller hæmmede bevægelser, manglende ansigtsudtryk, muskelhårdhed, stivhed i nakken,
English: Study Statistic Placebo Lurasidone dose (b)
Danish: Lurasidon doser (b)
English: • deliberate injury to oneself
Danish: • overlagt forsøg på at skade på sig selv
English: Monitoring is recommended when lurasidone and CYP3A4 substrates known to have a narrow therapeutic index (e.g. astemizole, terfenadine, cisapride, pimozide, quinidine, bepridil or ergot alkaloids [ergotamine, dihydroergotamine]) are coadministered.
Danish: Monitorering anbefales, når der samtidig gives CYP3A4-substrater, der vides at have et snævert terapeutisk indeks (f.eks. astemizol, terfenadin, cisaprid, pimozid, quinidin, bepridil eller ergotalkaloider [ergotamin, dihydroergotamin]).
English: Lurasidone was excreted in milk of rats during lactation.
Danish: Lurasidon udskilles i mælk hos diegivende rotter.
English: Kaplan-Meier estimates of the probability of relapse at Week 28 were 42.2% for lurasidone and 51.2% for placebo.
Danish: Kaplan-Meier estimater for sandsynligheden for tilbagefald ved uge 28 var 42,2 % for lurasidon og 51,2 % for placebo.
English: • enlarged breasts in male (gynecomastia), milky nipple discharge (galactorrhea), absence of menstruation (amenorrhea) or erectile dysfunction
Danish: • har forstørrede bryster hos mænd (gynækomasti), udflåd fra brystvorterne (galaktorré), fravær af menstruation (amernorré) eller erektil dysfunktion (impotens).
English: For strong CYP3A4 inhibitors and inducers see section 4.3.
Danish: For kraftige CYP3A4-hæmmere og -induktorer se pkt.
English: The concomitant administration of lurasidone and grapefruit juice has not been assessed.
Danish: Indtagelse af grapefrugtjuice sammen med lurasidon er ikke blevet undersøgt.
English: Lurasidone binds strongly to dopaminergic D2- and to serotonergic 5-HT2A and 5-HT7- receptors with high binding affinity of 0.994, 0.47 and 0.495 nM, respectively.
Danish: Lurasidon bindes kraftigt til dopaminerge D2- og til serotinerge 5-HT2A and 5-HT7-receptorer med høj bindingsaffinitet til hhv.
English: • sudden feelings of anxiety
Danish: • pludselige angstanfald
English: • aprepitant (to treat nausea and vomiting)
Danish: • aprepitant (til behandling af kvalme og opkastning)
English: Based on in vitro studies utilising human liver enzymes, lurasidone is not a substrate for CYP1A2; smoking should, therefore, not have an effect on the pharmacokinetics of lurasidone.
Danish: Baseret på in vitro-forsøg med humane leverenzymer er lurasidon ikke et substrat for CYP1A2.
English: Coadministration of lurasidone with diltiazem (slow-release formulation), a moderate CYP3A4 inhibitor, resulted in a 2.2 and 2.4-fold increase in exposure of lurasidone and ID-14283 respectively (see section 4.2).
Danish: Samtidig administration af lurasidon og diltiazem (protraheretfomuleringer), en moderate CYP3A4-hæmmer, medførte en 2,2- og 2,4-foldig øgning i eksponeringen for hhv. lurasidon og ID-14283 (se pkt.
English: Lurasidone should not be used during pregnancy unless clearly necessary.
Danish: Lurasidon bør ikke anvendes under graviditeten, medmindre kvindens kliniske tilstand kræver behandling med lurasidon.
English: High serum prolactin levels in long-term repeat-dose studies in female rats were associated with effects on bones, adrenal glands, and reproductive tissues.
Danish: Høje prolaktinniveauer i serum i studier af langvarige, gentagne doser hos hunrotter var forbundet med virkninger på knogler, binyrer og reproduktivt væv.
English: Mammary gland and/or pituitary gland tumours were observed in the mouse and rat carcinogenicity studies and are most likely due to the increased blood prolactin levels.
Danish: Karcinogenicitetsforsøg med mus og rotter viste en stigning i mammatumorer og tumorer i hypofysen, som efter al sandsynlighed skyldtes øgede prolaktiniveauer i blodet.
English: • low blood levels of sodium which can cause tiredness and confusion, muscle twitching, fits and coma (hyponatremia).
Danish: • lavt natriumniveau i blodet, som kan forårsage træthed og forvirring, muskelsammentrækninger,
English: The efficacy of lurasidone in the treatment of schizophrenia was demonstrated in five multi-centre, placebo-controlled, double-blind, 6-week trials in subjects who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for schizophrenia.
Danish: Virkningen af lurasidon ved behandling af skizofreni blev påvist i fem placebokontrollerede, dobbeltblindede multicenterforsøg af 6 ugers varighed med forsøgspersoner, som levede op til kriterierne for skizofreni iht.
English: Based on this data, lurasidone is not expected to affect the pharmacokinetics of medicinal products that are substrates of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1.
Danish: På baggrund af disse data forventes det ikke, at lurasidon påvirker farmakokinetikken for lægemidler, der er substrater for CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 og CYP2E1.
English: Lurasidone was excreted in milk of rats during lactation (see section 5.3).
Danish: Lurasidon udskilles i mælk hos diegivende rotter (se pkt.
English: • a severe allergic reaction seen as fever, swollen mouth, face, lip or tongue, shortness of breath,
Danish: • En alvorlig allergisk reaktion, der er karakteriseret ved feber, hævelser i mund, ansigt, læber eller tunge, kortåndethed, kløe, hududslæt og nogle gange et fald i blodtrykket.
English: Long-term maintenance efficacy of lurasidone (37 to 148 mg lurasidone once daily ) was demonstrated in a 12 month non-inferiority trial with quetiapine extended release (200 to 800 mg once daily).
Danish: Den langsigtede effekt af lurasidon (37-148 mg lurasidon givet én gang dagligt blev påvist ved et non-inferiority-forsøg af 12 måneders varighed med quetiapin, depottabter (200 til 800 mg én gang dagligt).