FrancophonIA/ELRC3.0 huggingface dataset:
English: The optimal starting dose for homozygous deficient patients has not been established (see section 4.4).
Croatian: Optimalna početna doza za bolesnike koji su homozigoti za deficit enzima nije utvrđena (vidjeti dio 4.4).
English: Two dosing syringes (a purple syringe graduated to 1 ml and a white syringe graduated to 5 ml) are provided for accurate measurement of the prescribed dose of the oral suspension.
Croatian: Dvije štrcaljke za doziranje (ljubičasta graduirana štrcaljka od 1 ml i bijela graduirana štrcaljka od 5 ml) dostupne su za točnu primjenu propisane doze oralne suspenzije.
English: Monitoring of the INR (International Normalised Ratio) value is recommended during concomitant administration with oral anticoagulants.
Croatian: Preporučuje se praćenje INR-a tijekom istodobne primjene s oralnim antikoagulansima.
English: Patients with inherited mutated NUDT15 gene are at increased risk for severe 6-mercaptopurine toxicity, (see 4.4).
Croatian: Bolesnici s naslijeđenim mutiranim genom NUDT15 pod povećanim su rizikom od teške toksičnosti 6-merkaptopurina (vidjeti 4.4).
English: Xaluprine should not be handled by women who are or planning to be pregnant or breast-feeding.
Croatian: Xaluprineom ne smiju rukovati žene koje planiraju zatrudnjeti ili dojiti.
English: Haematological toxicity is likely to be more profound with chronic overdose than with a single ingestion of Xaluprine.
Croatian: Hematološka toksičnost bit će izraženija kod kroničnog predoziranja nego pri primjeni jedne doze Xaluprina.
English: Effects of mercaptopurine on other medicinal products Concomitant administration of yellow fever vaccine is contraindicated, due to the risk of fatal disease in immunocompromised patients (see section 4.3)
Croatian: Istodobna primjena cjepiva protiv žute groznice kontraindicirana je zbog rizika od smrtonosne bolesti u imunokompromitiranih bolesnika (vidjeti dio 4.3)
English: 6-mercaptopurine is also subject to S-methylation by the enzyme thiopurine S-methyltransferase (TPMT), yielding methylmercaptopurine, which is inactive.
Croatian: 6-merkaptopurin također prolazi S-metilaciju pomoću tiopurin S-metiltransferaze (TPMT) kojom nastaje metilmerkaptopurin, koji je inaktivan.
English: When administered orally at a dosage of 75 mg/m2 to 7 paediatric patients, the bioavailability averaged 16% of the administered dose, with a range of 5 to 37%.
Croatian: 7 pedijatrijskih bolesnika bioraspoloživost je u prosjeku iznosila 16% primijenjene doze s rasponom od 5 do 37%.
English: One ml of suspension contains 3 mg aspartame, 1 mg methyl hydroxybenzoate (as the sodium salt), 0.5 mg ethyl hydroxybenzoate (as the sodium salt) and sucrose (trace).
Croatian: Jedan ml suspenzije sadrži 3 mg aspartama, 1 mg metilhidroksibenzoata (u obliku natrijeve soli), 0,5 mg etilhidroksibenzoata (u obliku natrijeve soli) i saharozu (u tragovima).
English: If you forget to take Xaluprine
Croatian: Ako ste zaboravili uzeti Xaluprine
English: The leucocyte and platelet counts continue to fall after treatment is stopped, so at the first sign of an abnormally large fall in the counts, treatment should be interrupted immediately.
Croatian: Broj leukocita i trombocita se nastavlja smanjivati i nakon završetka liječenja pa je odmah po pojavi znatnijeg pada broja stanica liječenje potrebno prekinuti.
English: Cases of symptomatic hypoglycaemia have been reported in children with ALL receiving 6-mercaptopurine (see section 4.8).
Croatian: Slučajevi simptomatske hipoglikemije prijavljeni su u djece s ALL-om koja primaju 6-merkaptopurin (vidjeti dio 4.8).
English: MIAS Pharma Limited Suite 2, Stafford House, Strand Road Postmarnock, Co. Dublin D13H525
Croatian: MIAS Pharma Limited Suite 2, Stafford House, Strand Road
English: For mercaptopurine there is a lack of modern clinical documentation which can serve as support for accurately determining the frequency of adverse reactions.
Croatian: Za merkaptopurin nedostaje novija klinička dokumentacija na temelju koje bi sa mogla točno procijeniti učestalost nuspojava.
English: The principal toxic effect is on the bone marrow, resulting in myelosuppression.
Croatian: Glavno toksično djelovanje je na koštanu srž, a rezultira mijelosupresijom.
English: Bone marrow suppression is reversible if 6-mercaptopurine is withdrawn early enough..
Croatian: Supresija koštane srži je reverzibilna ako se liječenje 6-merkaptopurinom prekine dovoljno rano.
English: The active substance is mercaptopurine (as monohydrate).
Croatian: Djelatna tvar je merkaptopurin (u obliku hidrata).
English: Patients should be closely monitored for dose related adverse reactions.
Croatian: Potrebno je pažljivo pratiti bolesnike zbog razvoja nuspojava povezanih s dozom.
English: Patients should be closely monitored for dose related adverse reactions (see section 4.4).
Croatian: Potrebno je pažljivo pratiti bolesnike zbog mogućeg razvoja nuspojava povezanih s dozom (vidjeti dio 4.4).
English: Put the cap back on the bottle with the adaptor left in place.
Croatian: 12. Vratite zatvarač na bočicu tako da nastavak ostane na mjestu.
English: These patients generally require dose reduction; particularly those being NUDT15 variant homozygotes (see 4.4).
Croatian: Tim je bolesnicima općenito potrebno smanjiti dozu, osobito onima koji su homozigoti za varijantu NUDT15 (vidjeti 4.4).
English: Some patients with inflammatory bowel disease who have received 6-mercaptopurine have developed a rare and aggressive type of cancer called Hepatosplenic T-cell Lymphoma (see section 4, Possible side effects).
Croatian: U nekih bolesnika s upalnom bolesti crijeva koji su primali 6-merkaptopurin došlo je do razvoja rijetkog i agresivnog tipa raka pod nazivom hepatosplenični T-stanični limfom (pogledajte dio 4.
English: 1 ml and 5 ml dosing syringes.
Croatian: Štrcaljke za doziranje od 1 ml i 5 ml.
English: They generally require dose reduction, particularly those being NUDT15 variant homozygotes (see 4.2).
Croatian: Njima je općenito potrebno smanjiti dozu, osobito onima koji su homozigoti za varijantu NUDT15 (vidjeti
English: Marketing Authorisation Holder Nova Laboratories Ireland Limited 3rd Floor, Ulysses House Foley Street, Dublin 1
Croatian: Nositelj odobrenja za stavljanje lijeka u promet Nova Laboratories Ireland Limited 3rd Floor, Ulysses House
English: Active measures (such as the use of activated charcoal or gastric lavage) may not be effective in the event of 6-mercaptopurine overdose unless the procedure can be undertaken within 60 minutes of ingestion.
Croatian: Aktivne mjere (poput uporabe aktivnog ugljena ili ispiranja želuca) možda neće biti djelotvorne kod 6-merkaptopurina,
English: May be harmful for people with phenylketonuria.
Croatian: Može biti štetan za osobe koje boluju od fenilketonurije.
English: Patients with inherited mutated NUDT15 gene are at increased risk for severe 6-mercaptopurine toxicity, such as early leukopenia and alopecia, from conventional doses of thiopurine therapy.
Croatian: Bolesnici s naslijeđenim mutiranim genom NUDT15 pod povećanim su rizikom od teške toksičnosti 6-merkaptopurina, kao što su rana leukopenija i alopecija, od uobičajenih doza tiopurina.
English: One ml of suspension contains 20 mg of mercaptopurine monohydrate.
Croatian: Jedan ml suspenzije sadrži 20 mg merkaptopurin hidrata.
English: No studies on the effect on the ability to drive and use machines have been performed.
Croatian: 4.7 Utjecaj na sposobnost upravljanja vozilima i rada sa strojevima Nisu provedena ispitivanja utjecaja na sposobnost upravljanja vozilima i rada sa strojevima.
English: - Allergic reaction, the signs may include: o skin rashes o high temperature o joint pain o swollen face
Croatian: Alergijske reakcije, znakovi mogu uključivati: - osip na koži
English: You should take your medicine at least 1 hour before or 2 hours after having milk or dairy products.
Croatian: Xaluprine je potrebno uzeti najmanje sat vremena prije ili 2 sata nakon konzumiranja mlijeka ili mliječnih proizvoda.
English: Hydration and urine alkalinisation may minimize potential renal complications.
Croatian: Hidracija i alkalizacija mokraće mogu smanjiti rizik od nastanka bubrežnih komplikacija.
English: Xaluprine also contains sodium methyl parahydroxybenzoate (E219) and sodium ethyl parahydroxybenzoate (E215) which may cause allergic reactions (possibly delayed).
Croatian: Xaluprine također sadrži natrijev metilparahidroksibenzoat (E219) i natrijev etilparahidroksibenzoat (E215) koji mogu uzrokovati alergijske reakcije (koje mogu biti odgođene).
English: If Xaluprine comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Croatian: Ako Xaluprine dođe u dodir s kožom ili sluznicama,treba ih odmah temeljito isprati sapunom i vodom.
English: The histological findings in man have shown hepatic necrosis and biliary stasis
Croatian: Histološke analize u ljudi pokazale su nekrozu jetre i zastoj žuči.
English: Always use the syringes provided to take your medicine.
Croatian: Za uzimanje lijeka uvijek koristite priložene štrcaljke.
English: The dose is governed by cautiously monitored haematotoxicity and the dose should be carefully adjusted to suit the individual patient in accordance with the employed treatment protocol.
Croatian: Doza se pažljivo prilagođava uzimajući u obzir uočenu hematotoksičnost i individualne potrebe bolesnika u okviru aktivnog protokola liječenja.
English: INFORMATION IN BRAILLE Xaluprine 20 mg/ml
Croatian: Xaluprine 20 mg/ml
English: There is low entry of 6-mercaptopurine into the cerebrospinal fluid.
Croatian: Prolazak 6-merkaptopurina u cerebrospinalni likvor je nizak.
English: Xaluprine contains sucrose.
Croatian: Xaluprine sadrži saharozu.
English: Allopurinol and other xanthine oxidase inhibitors decrease the rate of catabolism of 6-mercaptopurine.
Croatian: Kombinacija s inhibitorima ksantin oksidaze Alopurinol i drugi inhibitori ksantin oksidaze smanjuju brzinu katabolizma 6-merkaptopurina.
English: The patient should be instructed to discontinue Xaluprine immediately if jaundice becomes apparent (see section 4.8).
Croatian: Bolesnike je potrebno savjetovati da u slučaju pojave žutice odmah prekinu liječenje Xaluprineom (vidjeti dio 4.8).
English: BSA (m2) Dose (mg)
Croatian: Doza (mg)
English: Prior exposure to or infection with varicella zoster virus should be taken into consideration prior to starting treatment.
Croatian: Prije početka liječenja trebalo bi uzeti u obzir je li bolesnik prethodno izložen virusu varicella zoster ili zaražen virusom varicella zoster.
English: Your doctor or pharmacist will advise which syringe to use depending on the dose that has been prescribed.
Croatian: Vaš liječnik ili ljekarnik savjetovat će vam koju ćete štrcaljku upotrijebiti za dozu koja Vam je propisana.
English: 5.3 Preclinical safety data
Croatian: 5.3 Neklinički podaci o sigurnosti primjene Genotoksičnost
English: The first step is catalysed by hypoxanthine-guanine phosphoribosyl transferase yielding thioinosine monophosphate (TIMP).
Croatian: Prvi korak katalizira hipoksantin-gvaninfosforibozil transferaza pri čemu nastaje tioinozin monofosfat.
English: The main adverse reaction of treatment with 6-mercaptopurine is bone marrow suppression leading to leucopenia and thrombocytopenia.
Croatian: Glavna nuspojava liječenja 6-merkaptopurinom je supresija koštane srži koja dovodi do leukopenije i trombocitopenije.
English: Genotypic testing of NUDT15 variants may be considered before initiating 6-mercaptopurine therapy.
Croatian: Prije početka liječenja 6-merkaptopurinom može se uzeti u obzir genotipizacija varijanti NUDT15.
English: Cases of neutropenic sepsis have been reported in patients receiving 6-mercaptopurine for ALL.
Croatian: Slučajevi neutropenične sepse prijavljeni su u bolesnika koji primaju 6-merkaptopurin za ALL.
English: Serologic testing prior to starting treatment should be considered with respect to hepatitis B. Local guidelines may be considered, including prophylactic therapy for cases which have been confirmed positive by serologic testing.
Croatian: Mogu se razmotriti lokalne smjernice, uključujući profilaktičko liječenje za slučajeve koji su se na serološkom ispitivanju pokazali pozitivni.
English: Both TIMP and mTIMP are inhibitors of phosphoribosyl pyrophosphate amidotransferase, an enzyme which is important in de novo purine synthesis.
Croatian: I tioinozin monofosfat i metiltioinozin monofosfat su inhibitori fosforibozil pirofosfat amidotransferaze, enzima koji je važan u de novo sintezi purina.
English: TPMT also catalyses the S-methylation of the principle nucleotide metabolite, TIMP, to form methylthioinosine monophosphate (mTIMP).
Croatian: Međutim, TPMT također katalizira S-metilaciju glavnog nukleotidnog metabolita tioinozin monofosfata pri čemu nastaje metiltioinozin monofosfat.
English: Your pack of Xaluprine contains a bottle of medicine, a cap, a bottle adaptor and two dosing syringes (a purple 1 ml syringe and a white 5 ml syringe).
Croatian: Vaše pakiranje Xaluprinea sadrži bočicu lijeka, zatvarač, nastavak za bočicu i dvije štrcaljke za doziranje (ljubičasta štrcaljka od 1 ml i bijela od 5 ml).
English: - Any unexpected bruising or bleeding, as this could mean that too few blood cells of a particular type are being produced
Croatian: Bilo koji znakovi vrućice ili infekcije (grlobolja, bolna usta ili problemi s mokrenjem) Bilo kakav neočekivani nastanak modrica ili krvarenje, jer to može značiti da se stvara premalo krvnih stanica određenog tipa.
English: Xaluprine is cytotoxic.
Croatian: Xaluprine je citotoksičan.
English: Evidence of the teratogenicity of 6-mercaptopurine in humans is equivocal.
Croatian: Teratogenost 6-merkaptopurina u ljudi nije definitivno potvrđena.
English: Mutagenicity and carcinogenicity
Croatian: Mutagenost i kancerogenost
English: How to take Xaluprine
Croatian: Kako uzimati Xaluprine
English: Arthralgia, skin rash, drug fever
Croatian: Artralgija, osip na koži, jatrogena vrućica
English: Pancreatitis, oral ulceration
Croatian: Pankreatitis, ulceracije u usnoj šupljini
English: Xaluprine 20 mg/ml oral suspension mercaptopurine
Croatian: Xaluprine 20 mg/ml oralna suspenzija merkaptopurin
English: Xaluprine contact with skin or mucous membrane must be avoided.
Croatian: Mora se izbjegavati kontakt Xaluprina s kožom ili sluznicama.
English: Shake the bottle vigorously for at least 30 seconds to ensure the medicine is well mixed (figure 1).
Croatian: 2. Snažno tresite bočicu najmanje 30 sekundi kako biste osigurali da je lijek dobro promiješan
English: Push the tip of the dosing syringe into the hole in the adaptor (figure 4).
Croatian: Gurnite vrh štrcaljke za doziranje u otvor nastavka (slika 4).
English: 6-mercaptopurine is an inactive pro-drug which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides for cytotoxicity.
Croatian: 6-merkaptopurin je neaktivni predlijek koji djeluje kao antagonist purina, ali mu je za citotoksični učinak potreban unos u stanicu i unutarstanična dogradnja do tiogvaninskih nukleotida.
English: Excipients with known effect
Croatian: Pomoćna(e) tvar(i) s poznatim učinkom:
English: Biliary stasis, hepatotoxicity
Croatian: Zastoj žuči, hepatoksičnost
English: Other side effects (the frequency is unknown) - a rare type of cancer (hepatosplenic T-cell lymphoma), (see section 2, Warnings and
Croatian: Ostale nuspojave (učestalost nepoznata) - rijetki tip raka (hepatosplenični T-stanični limfom), (pogledajte dio 2. Upozorenja i mjere opreza) - Osjetljivost na sunčevu svjetlost s reakcijama na koži
English: The intracellular anabolism of 6-merpactopurine is catalysed by several enzymes to eventually form 6-thioguanine nucleotides (TGNs), but a variety of intermediary TGNs are formed en route to the TGNs.
Croatian: Biotransformacija Unutarstaničnu dogradnju 6-merkaptopurina katalizira nekoliko enzima do konačnog stvaranja nukleotida 6-tiogvanina, ali pri tome nastaje niz međuspojeva nukleotida 6-tiogvanina.
English: 100 ml glass bottle Bottle adaptor
Croatian: Staklena bočica od 100 ml Nastavak za bočicu
English: The expiry date refers to the last day of that month, - Do not store above 25°C.
Croatian: Rok valjanosti odnosi se na zadnji dan navedenog mjeseca.
English: Rare (affects less than 1 in 1,000 people) - hair loss - in men: temporary low sperm count - swollen face - various types of cancers including blood, lymph and skin cancers
Croatian: - u muškaraca: privremeni pad količine sperme - otečeno lice - različite vrste raka uključujući rak krvi, limfnog sustava i kože
English: The other ingredients are xanthan gum, aspartame (E951), concentrated raspberry juice, sucrose, sodium methyl parahydroxybenzoate (E219), sodium ethyl parahydroxybenzoate (E215), potassium sorbate (E202), sodium hydroxide and purified water (see section 2 Xaluprine contains aspartame, sodium methyl parahydroxybenzoate (E219), sodium ethyl parahydroxybenzoate (E215) and sucrose).
Croatian: Drugi sastojci su ksantanska guma, aspartam (E951), koncentrirani sok maline, saharoza, natrijev metilparahidroksibenzoat (E219), natrijev etilparahidroksibenzoat (E215), kalijev sorbat (E202), natrijev hidroksid i pročišćena voda (pogledajte dio 2 za dodatne informacije o aspartamu, natrijevu metilparahidroksibenzoatu (E219), natrijevu etilparahidroksibenzoatu (E215) i saharozi).
English: Patients treated with 6-mercaptopurine alone or in combination with other immunosuppressive agents, including corticosteroids, have shown increased susceptibility to viral, fungal and bacterial infections, including severe or atypical infection, and viral reactivation.
Croatian: uključujući kortikosteroide, pokazali su povećanu podložnost virusnim, gljivičnim i baketrijskim infekcijama, uključujući teške ili atipične infekcije i reaktivaciju virusa.
English: How to store Xaluprine
Croatian: Kako čuvati Xaluprine
English: The risk of overdose is also increased when xanthine oxidase inhibitors is being given concomitantly with 6-mercaptopurine (see section 4.5).
Croatian: Rizik od predoziranja također je povećan pri istodobnoj primjeni inhibitora ksantin oksidaze (vidjeti dio 4.5).
English: Inhibition of the anticoagulant effect of warfarin, when given with 6-mercaptopurine, has been reported.
Croatian: Zabilježena je inhibicija antikoagulantnog učinka varfarina pri istodobnoj primjeni sa
English: Having vaccines while you are taking Xaluprine If you are going to have a vaccination it is important to speak to your doctor or nurse before you have it. Vaccination with live vaccines (like polio, measles, mumps and rubella) is not recommended, as these vaccines may give you an infection if you have them whilst you are taking Xaluprine.
Croatian: Cijepljenje živim cjepivom (poput cjepiva protiv dječje paralize, ospica, zaušnjaka i rubeole) nije preporučljivo jer od tih cjepiva možete dobiti infekciju ako ih primite istovremeno s Xaluprineom.
English: This may be harmful for people with phenylketonuria.
Croatian: Može štetiti osobama koje boluju od fenilketonurije.
English: Stomatitis, diarrhoea, vomiting, nausea
Croatian: Stomatitis, proljev,
English: Xaluprine with food and drink
Croatian: Xaluprine s hranom i pićem Xaluprine se može uzimati s hranom ili natašte.
English: This belongs to a group of medicines called cytotoxics (also called chemotherapy).
Croatian: On pripada skupini lijekova koje nazivamo citotoksični lijekovi
English: See section 4
Croatian: Slika 4
English: If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Croatian: Ako se bilo koja nuspojava pogorša ili ako primijetite bilo koju nuspojavu koja nije navedena u ovoj
English: What Xaluprine looks like and contents of the pack Xaluprine is a pink to brown oral suspension.
Croatian: Xaluprine je ružičasta do smeđa oralna suspenzija.
English: To decrease the risk of exposure disposable gloves should be used when handling Xaluprine.
Croatian: Kako biste smanjili rizik od izlaganja, prilikom rukovanja Xaluprineom koristite rukavice za jednokratnu uporabu.
English: Facial oedema
Croatian: Edem lica
English: Neoplasms including lymphoproliferative disorders, skin cancers (melanomas and non-melanomas), sarcomas (Kaposi's and non-Kaposi's) and uterine cervical cancer in situ (see section 4.4).
Croatian: (melanomski i nemelanomski), sarkome (Kaposijev i ne-Kaposijev) te rak vrata maternice in situ (vidjeti dio 4.4.).
English: Intestinal ulceration
Croatian: Ulceracije na crijevima
English: TPMT genotyping or phenotyping can be used to identify patients with absent or reduced TPMT activity.
Croatian: Za identifikaciju bolesnika bez aktivnosti ili s reduciranom aktivnošću TPMT-a može se koristiti TPMT genotipiziranje ili fenotipiziranje.
English: You should use this one if the total amount you have to take is more than 1 ml (each graduation of 0.2 ml contains 4 mg of mercaptopurine).
Croatian: 1 ml (svaka graduacija od 0,1 ml sadrži 2 mg merkaptopurina).
English: Pancreatitis in off-label treatment of patients with inflammatory bowel disease Pancreatitis has been reported to occur at a frequency of ≥ 1/100 to < 1/10 (“common”) in patients treated for the unlicensed indication inflammatory bowel disease.
Croatian: Učestalost pankreatitisa u bolesnika liječenih zbog upalne bolesti crijeva, koja nije odobrena indikacija, bila je od ≥ 1/100 do < 1/10 („često“).
English: Slowly and gently push the plunger down to gently squirt the medicine into the inside of your cheek and swallow it. DO NOT forcefully push down the plunger, or squirt the medicine to the back of your mouth or throat, as you may choke.
Croatian: NEMOJTE na silu pritiskati klip ili uštrcavati lijek u stražnji dio usta ili grla jer se možete ugušiti.
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2).
Croatian: Lijek se izdaje na ograničeni recept (vidjeti Prilog I: Sažetak opisa svojstava lijeka, dio 4.2).
English: olsalazine, mesalazine or sulfazalazine) inhibit the TPMT enzyme, which metabolises 6-mercaptopurine, they should be administered with caution to patients receiving concurrent Xaluprine therapy (see section 4.4).
Croatian: S obzirom na postojeće in vitro dokaze inhibicije TPMT-a koji metabolizira 6-merkaptopurin derivatima aminosalicilata (primjerice, olsalazinom, mesalazinom ili sulfasalazinom) potreban je oprez pri njihovoj primjeni u bolesnika koji istovremeno primaju Xaluprine (vidjeti dio 4.4).
English: Effects of other medicinal products on mercaptopurine When allopurinol and Xaluprine are administered concomitantly it is essential that only a quarter of the usual dose of Xaluprine is given since allopurinol decreases the rate of metabolism of 6-mercaptopurine via xanthine oxidase.
Croatian: Pri istodobnoj primjeni alopurinola i Xaluprina, nužno je primijeniti samo četvrtinu uobičajene doze Xaluprina budući da alopurinol smanjuje brzinu metabolizma
English: Xaluprine contains aspartame, sodium methyl parahydroxybenzoate (E219), sodium ethyl parahydroxybenzoate (E215) and sucrose
Croatian: Xaluprine sadrži aspartam, natrijev metilparahidroksibenzoat (E219), natrijev etilparahidroksibenzoat (E215) i saharozu
English: Blood levels of anti-epileptic medicines may need to be monitored and doses adjusted if necessary.
Croatian: Razine antiepileptika u krvi potrebno je mjeriti te prema potrebi prilagoditi doze.
English: You should use this one if the total amount you have to take is less than or equal to 1 ml (each graduation of 0.1 ml contains 2 mg of mercaptopurine).
Croatian: Tu štrcaljku trebate koristiti ako je ukupna količina koju trebate uzeti veća od 1 ml (svaka graduacija od
English: o A combination of multiple immunosuppressants, given concomitantly increases the risk of disorders of the lymph system due to a viral infection (Epstein-Barr virus (EBV)-associated lymphoproliferative disorders).
Croatian: Uz režim liječenja koji sadrži višestruke imunosupresive (uključujući tiopurine), može doći do smrti. o kombinacija višestrukih imunosupresiva koji se istodobno primjenjuju povećava rizik od poremećaja limfnog sustava kao posljedice virusne infekcije (limfoproliferativni poremećaji povezani s Epstein-Barrovim virusom (EBV)).