FrancophonIA/ELRC3.0 huggingface dataset:
English: IONSYS is a small device applied to the skin of your upper arm or chest.
Slovenian: IONSYS je majhen pripomoček, ki se namesti na kožo nadlahti ali prsi.
English: IONSYS should, therefore, be used with caution in these patients.
Slovenian: Zato je pri uporabi zdravila IONSYS pri teh bolnikih potrebna previdnost.
English: Oral ritonavir, one of the most potent CYP3A4 inhibitors, reduced the clearance of intravenous fentanyl by two thirds.
Slovenian: Peroralni ritonavir, eden najmočnejših zaviralcev encima CYP3A4, je zmanjšal očistek intravensko apliciranega fentanila za dve tretjini.
English: The manifestations of fentanyl overdose are an extension of its pharmacologic actions, the most serious effect being respiratory depression (see section 5.2).
Slovenian: Znaki prevelikega odmerjanja fentanila so povečanje farmakoloških učinkov zdravila, med katerimi je najresnejši učinek depresija dihanja (glejte poglavje 5.2).
English: This leaflet was last revised in MM/YYYY
Slovenian: Navodilo je bilo nazadnje revidirano dne <{MM/LLLL}>.
English: Other medicines and IONSYS Tell your doctor or nurse if you are using, have recently used or might use any other medicines.
Slovenian: Obvestite zdravnika ali medicinsko sestro, če uporabljate, ste pred kratkim uporabljali ali pa boste morda začeli uporabljati katero koli drugo zdravilo.
English: IONSYS should not be administered during childbirth.
Slovenian: Zdravilo IONSYS se ne sme uporabljati med porodom.
English: Absorption of fentanyl from IONSYS is similar whether applied to the upper outer arm or chest.
Slovenian: Absorpcija fentanila iz sistema IONSYS je podobna uporabi na zunanjem delu nadlahti ali na prsih.
English: IONSYS is removed from the patient by lifting the system at the red tab and peeling it away from the skin site.
Slovenian: Sistem IONSYS se odstrani z bolnika tako, da se dvigne pri rdečem zavihku in odlepi s kožnega predela.
English: Treatment should be initiated by and remain under the guidance of a physician experienced in the management of opioid therapy.
Slovenian: Zdravljenje sme uvesti in voditi samo zdravnik, ki ima izkušnje z zdravljenjem z opioidi.
English: Data on IONSYS in paediatrics is limited to information from a single clinical trial.
Slovenian: Pediatrična populacija Podatki o uporabi zdravila IONSYS pri pediatrični populaciji so omejeni na eno klinično preskušanje.
English: If IONSYS is administered to the mother during this time, an antidote for the child should be readily available.
Slovenian: Če mati v tem času prejme zdravilo IONSYS, mora biti na voljo protisredstvo za otroka.
English: Data obtained with intravenous fentanyl in patients with renal failure suggest that the volume of distribution of fentanyl may be changed by dialysis.
Slovenian: Podatki, pridobljeni z intravensko uporabo fentanila pri bolnikih z odpovedjo ledvic, kažejo, da lahko dializa spremeni volumen porazdelitve fentanila.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT 80 doses
Slovenian: VSEBINA, IZRAŽENA Z MASO, PROSTORNINO ALI ŠTEVILOM ENOT 80 odmerkov
English: IONSYS is for transdermal use only.
Slovenian: Zdravilo IONSYS je samo za transdermalno uporabo.
English: The green light will change from a slow flash rate to a rapid flash rate and the digital display will alternate between a rotating circle and the number of completed doses during the entire 10-minute dose delivery period.
Slovenian: Utripanje zelene lučke preide s počasnega na hitrega in digitalni prikazovalnik med celotnim 10-minutnim obdobjem odmerjanja izmenično prikazuje vrtenje krožca in število zaključenih odmerkov.
English: • you have problems with your liver or kidneys
Slovenian: • če imate težave z jetri ali ledvicami;
English: Each IONSYS system is packaged in a sealed thermoform tray.
Slovenian: Vsak sistem IONSYS je pakiran na zatesnjenem toplotno oblikovanem podstavku.
English: Do not drive, operate machines or power tools when you leave hospital if you experience any of these side effects.
Slovenian: Ko zapustite bolnišnico, ne vozite in ne upravljajte strojev ali električnega orodja, če imate katerega od teh neželenih učinkov.
English: With each new IONSYS application the patient may use IONSYS more frequently than during the remainder of the 24 hour dosing period, due to a lower absorption of fentanyl from the system for the first few hours (see section 5.2).
Slovenian: Zaradi manjše absorpcije fentanila iz sistema v prvih nekaj urah bo morda bolnik ob vsaki namestitvi novega sistema IONSYS uporabljal zdravilo IONSYS pogosteje kot med preostankom 24-urnega obdobja odmerjanja (glejte poglavje 5.2).
English: Fentanyl should be used with caution in patients with brain tumours or other significant space occupying lesions of the brain.
Slovenian: Fentanil je treba uporabljati previdno pri bolnikih z možganskimi tumorji ali drugimi pomembnimi spremembami, ki zasedajo prostor v možganih.
English: Patients should be titrated to an acceptable level of analgesia prior to initiating use of IONSYS (see section 5.1).
Slovenian: Pred začetkom uporabe zdravila IONSYS je treba bolnikom povečati odmerek analgetika, dokler se ne doseže sprejemljiva raven analgezije (glejte poglavje 5.1).
English: No overall differences were observed in the safety of IONSYS fentanyl 40 micrograms in elderly patients (≥ 65 years including a subpopulation ≥ 75 years) and adult patients for all controlled studies.
Slovenian: V nobeni od nadzorovanih študij niso ugotovili splošnih razlik v varnosti zdravila IONSYS s 40 mikrogrami fentanila med starejšimi (≥ 65 let, vključno s podskupino ≥ 75 let) in odraslimi bolniki.
English: Low battery or defective system
Slovenian: Potrebni ukrep skoraj prazna baterija ali okvarjen sistem
English: IONSYS is indicated for the management of acute moderate to severe post-operative pain in adult patients.
Slovenian: Sistem IONSYS je indiciran za zdravljenje akutne zmerne do hude pooperativne bolečine pri odraslih bolnikih.
English: IONSYS was also evaluated in four active-control trials (predominantly female (65%), Caucasian (85%), with a mean age of 55 years (range, 18-91 years), and primarily comprised of surgeries including lower abdominal and orthopedic bone procedures) using a standard intravenous patient controlled analgesia (PCA) morphine regimen as the comparator.
Slovenian: Zdravilo IONSYS so ocenili tudi v štirih z zdravilno učinkovino nadzorovanih preskušanjih (pretežno pri ženskah (65 %), bele rase (85 %), s povprečno starostjo 55 let (razpon 18-91 let), večinoma po kirurških posegih na spodnjem delu trebuha in ortopedskih posegih), kjer so za primerjalno učinkovino uporabili standardni režim intravenske analgezije z morfinom, ki jo nadzoruje bolnik (PCA).
English: Co-administration of fentanyl with a serotoninergic agent, such as a Selective Serotonin Re-uptake Inhibitor (SSRI) or a Serotonin Norepinephrine Re-uptake Inhibitor (SNRI) or a Monoamine Oxidase Inhibitor (MAOI), may increase the risk of serotonin syndrome, a potentially life-threatening condition.
Slovenian: Serotoninergična zdravila Sočasna uporaba fentanila s serotoninergično učinkovino, kot je selektiven zaviralec ponovnega privzema serotonina (SSRI), zaviralec ponovnega privzema serotonina in noradrenalina (SNRI) ali zaviralec monoamin-oksidaze (MAO), lahko poveča tveganje za potencialno smrtno nevarni serotoninski sindrom.
English: The dosing button must not be pressed.
Slovenian: Gumba za odmerjanje ne smete pritisniti.
English: If you are given IONSYS during childbirth your baby may need to be given an antidote when it is born.
Slovenian: Če prejmete zdravilo IONSYS med porodom, bo dojenček morda moral ob rojstvu dobiti protisredstvo.
English: If you have a history of drug abuse, inform your doctor.
Slovenian: Če ste v preteklosti zlorabljali droge ali zdravila, o tem obvestite svojega zdravnika.
English: At the end of 24 hours of use, or after 80 doses have been administered, the green light will switch off and the number of doses delivered will flash on and off.
Slovenian: Ob koncu 24-urne uporabe ali po sprostitvi 80 odmerkov se zelena lučka izklopi in število dovedenih odmerkov utripa.
English: Published literature has indicated that the CYP3A4*22 and CYP3A5*3 single nucleotide polymorphisms influence fentanyl to norfentanyl metabolism with the potential for increased fentanyl exposure in patients with these genetic polymorphs.
Slovenian: Objavljena literatura navaja, da polimorfizma z enojnim nukleotidom CYP3A4*22 in CYP3A5*3 vplivata na presnovo fentanila v norfentanil s potencialom za povečano izpostavljenost fentanilu pri bolnikih s temi genetskimi polimorfizmi.
English: 23-24 Tafarnaubach Industrial Estate Tredegar
Slovenian: Tafarnaubach Industrial Estate Gwent
English: Rash Hyperhidrosis
Slovenian: hiperhidroza
English: If patients with renal impairment receive IONSYS, they should be observed carefully for signs of fentanyl toxicity.
Slovenian: Če bolniki z okvaro ledvic prejemajo zdravilo IONSYS, jih je treba skrbno opazovati glede znakov toksičnosti fentanila.
English: • Summary of Product Characteristics (SmPC) and Package Leaflet
Slovenian: • povzetek glavnih značilnosti zdravila (SmPC) in navodilo za uporabo,
English: Used systems should not be reapplied to a patient.
Slovenian: Uporabljeni sistemi se ne smejo ponovno namestiti.
English: When applying tape, care should be taken not to tape over the light window, the digital display, or the dosing button.
Slovenian: Pri nameščanju traku pazite, da ne prelepite svetlobnega okna, digitalnega prikazovalnika ali gumba za odmerjanje.
English: Breast-feeding is not recommended for 24 hours following removal of IONSYS.
Slovenian: Dojenje se odsvetuje še 24 ur po odstranitvi sistema IONSYS.
English: Less than 10% of administered fentanyl is excreted unchanged by the kidney.
Slovenian: Manj kot 10 % danega fentanila se izloči v nespremenjeni obliki skozi ledvice.
English: • tingling, prickling, swelling or pain at site of IONSYS application
Slovenian: • mravljinčenje, zbadanje, oteklina ali bolečina na mestu namestitve pripomočka IONSYS
English: The used IONSYS system contains a dangerous amount of fentanyl within the red hydrogel housing.
Slovenian: Uporabljen sistem IONSYS vsebuje v rdečem hidrogelnem ohišju nevarno količino fentanila.
English: • you have any difficulty hearing as you will need to be able to hear the device's ‘beep(s)' to know if it is working properly or if there is a problem
Slovenian: • če imate kakršne koli težave s sluhom, saj boste morali slišati piskanje pripomočka, da boste vedeli, ali deluje pravilno ali se je pojavila težava; • če nenormalno redko odvajate blato ali ste hudo zaprti;
English: At the end of the self-test, the display will show the number “0” and a green light will flash at a slow rate to indicate IONSYS is ready for application.
Slovenian: Ob koncu samotestiranja se na zaslonu prikaže številka »0« in zelena lučka počasi utripa, kar označuje, da je sistem IONSYS pripravljen za uporabo.
English: Fentanyl is metabolised primarily in the liver to norfentanyl by CYP3A4 isoform.
Slovenian: Fentanil se presnavlja zlasti v jetrih v norfentanil ob pomoči izoforme CYP3A4.
English: Marketing Authorisation Holder Incline Therapeutics Europe Ltd 21 St. Thomas Street Bristol
Slovenian: Imetnik dovoljenja za promet z zdravilom Incline Therapeutics Europe Ltd 21 St. Thomas Street
English: For further details, see section 6.6.
Slovenian: Več podrobnosti je na voljo v poglavju 6.6.
English: About 9% of the dose is recovered in the faeces, primarily as metabolites.
Slovenian: Približno 9 % odmerka se izloči z blatom, zlasti v obliki presnovkov.
English: The overall adverse reaction profile for morbidly obese patients (BMI > 40) does not suggest a meaningful difference in safety compared to patients with BMI ≤ 40.
Slovenian: Splošni profil neželenih učinkov pri bolezensko debelih bolnikih (ITM > 40) ne kaže na pomembne razlike v varnosti v primerjavi z bolniki z ITM ≤ 40.
English: These studies evaluated IONSYS vs. intravenous PCA morphine in various surgical procedures commonly seen in clinical practice.
Slovenian: V teh študijah so ocenili zdravilo IONSYS v primerjavi z intravenskim zdravljenjem PCA z morfinom po različnih kirurških posegih, ki so v klinični praksi pogosti.
English: • Remove the drug unit from the sachet and place on a hard, flat
Slovenian: • Odstranite zdravilno enoto iz vrečke in jo postavite na trdo,
English: To dispose of a used IONSYS system:
Slovenian: Postopek odlaganja uporabljenega sistema IONSYS:
English: Injury, poisoning and procedural complications
Slovenian: Poškodbe in zastrupitve in zapleti pri posegih zaplet v zvezi z rano
English: Similar to the placebo-controlled studies, in the immediate postoperative period, patients were titrated to comfort with intravenous fentanyl or morphine per hospital protocol.
Slovenian: Podobno kot v s placebom nadzorovanih študijah so v neposrednem pooperativnem obdobju bolnikom povečevali odmerek intravenskega fentanila ali morfina skladno z bolnišničnim protokolom, dokler se niso počutili dobro.
English: If you experience any of these symptoms then tell your doctor or nurse immediately.
Slovenian: Če imate katerega koli od teh simptomov, takoj obvestite zdravnika ali medicinsko sestro.
English: IONSYS is used to treat short-term moderate to severe pain in adults after an operation.
Slovenian: Zdravilo IONSYS se uporablja za zdravljenje kratkotrajnih zmernih do hudih bolečin pri odraslih po kirurških posegih.
English: Average serum concentrations observed in post-surgical patients were in the range of 0.4-1.5 ng/ml over a 24 hour dosing period.
Slovenian: Povprečne serumske koncentracije, izmerjene pri bolnikih po operaciji, so bile v 24-urnem obdobju odmerjanja v območju 0,4-1,5 ng/ml.
English: • inability to pass water (urinate)
Slovenian: • nezmožnost odvajanja vode (uriniranja) • zvišana telesna temperatura
English: IONSYS may make you feel sleepy, dizzy or cause blurred vision.
Slovenian: Zaradi uporabe zdravila IONSYS se lahko počutite zaspani, omotični ali imate meglen vid.
English: Across the active-controlled studies, dosing with IONSYS was similar to intravenous PCA morphine pump use.
Slovenian: V z zdravilno učinkovino nadzorovanih študijah je bilo odmerjanje zdravila IONSYS podobno kot pri uporabi intravenske črpalke PCA z morfinom.
English: If the patient requires additional treatment for pain, a new system may be applied to a new skin site on the upper outer arm or chest.
Slovenian: Če bolnik potrebuje dodatno lajšanje bolečine, se lahko namesti nov sistem na drug kožni predel na zunanjem delu nadlahti ali prsih.
English: Open the sachet containing the drug unit starting at the pre-cut notch and then carefully tearing along the top of the sachet.
Slovenian: Vrečko, ki vsebuje zdravilno enoto, začnite odpirati ob zarezi, nato pa previdno odtrgajte vrh vrečke.
English: If IONSYS appears to be loose or lifting from the skin, secure it to patient's skin by pressing the edges firmly or by applying non-allergenic tape.
Slovenian: Če se je sistem IONSYS zrahljal ali dvignil s kože, ga trdno namestite na bolnikovo kožo tako, da močno pritisnete robove ali uporabite nealergen lepilni trak.
English: Upon successful dose initiation, IONSYS will emit a beep indicating the start of delivery.
Slovenian: Po uspešni sprožitvi sistem IONSYS zapiska, kar označuje začetek dovajanja odmerka.
English: The Drug Unit should be removed from the sachet and the Controller should be snapped on by aligning the shape and firmly pressing the two parts together.
Slovenian: Odstranite zdravilno enoto iz vrečke in namestite nanjo upravljalnik tako, da poravnate oba dela in ju trdno pritisnete skupaj.
English: Fentanyl is metabolised into inactive metabolites in the liver.
Slovenian: Fentanil se v jetrih presnavlja v neaktivne presnovke.
English: The controller is white with the identifier ‘IONSYS®' and has a digital display, a light window, and a recessed dose activation button.
Slovenian: Upravljalnik je bel z napisom »IONSYS®« ter ima digitalni prikazovalnik, svetlobno okence in vdrt gumb za aktivacijo odmerka.
English: • Dispose of the folded hydrogel housing in accordance with local requirements for opioid medicinal products
Slovenian: • Zloženo hidrogelno ohišje zavrzite po lokalnih predpisih za odstranjevanje opioidnih zdravil.
English: Fentanyl exhibits three compartment distribution pharmacokinetics.
Slovenian: Fentanil ima tripredelno porazdelitveno farmakokinetiko.
English: The concomitant use of potent CYP3A4 inhibitors (e.g., as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, and nelfinavir) or moderate CYP3A4 inhibitors (e.g., amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil) with IONSYS may result in an increase in fentanyl plasma concentrations, which could increase or prolong both the therapeutic effect and adverse reactions, and may cause serious respiratory depression.
Slovenian: ketokonazol, itrakonazol, troleandomicin, klaritromicin in nelfinavir) ali zmernih zaviralcev CYP3A4 (npr. amprenavir, aprepitant, diltiazem, eritromicin, flukonazol, fosamprenavir, sok grenivke in verapamil) z zdravilom IONSYS lahko pripelje do zvišanja plazemskih koncentracij fentanila, kar lahko poveča ali podaljša terapevtske in neželene učinke ter povzroči resno depresijo dihanja.
English: Physical status
Slovenian: Zdravstveno stanje
English: Rare (may affect up to 1 in 1,000 people)
Slovenian: Redki (lahko se pojavijo pri manj kot 1 osebi od 1000)
English: • you are taking medicines for bacterial infections (such as troleandomycin, clarithromycin or
Slovenian: • jemljete zdravila za zdravljenje bakterijskih okužb (npr. troleandomicin, klaritromicin ali eritromicin);
English: Hold down dosing button until beeping stops and display goes blank.
Slovenian: Držite gumb za odmerjanje, dokler piskanje ne preneha in prikaz izgine.
English: Patients were initially titrated to comfort with intravenous fentanyl or morphine, at which point they were randomized to IONSYS or a matching placebo system.
Slovenian: Bolnikom so prvotno povečevali intravenske odmerke fentanila ali morfina, dokler se niso dobro počutili, nato pa so bili randomizirani za prejemanje zdravila IONSYS ali ujemajočega se sistema s placebom.
English: After IONSYS has been removed, it may leave small reddish marks at the skin site.
Slovenian: Odstranjen sistem IONSYS lahko pusti majhne rdečkaste sledi na kožnem predelu.
English: The tray contains one Controller and one sachet containing a Drug Unit.
Slovenian: Podstavek vsebuje en upravljalnik in eno vrečko z zdravilno enoto.
English: After the 10-minute dose has been completely delivered, the green light will return to a slow flash rate, the digital display will show the number of doses that have been delivered, and IONSYS will be ready to be used again by the patient.
Slovenian: Po zaključenem 10-minutnem odmerjanju zelena lučka znova začne utripati počasi, digitalni prikazovalnik prikaže število dovedenih odmerkov in sistem IONSYS je pripravljen za ponovno uporabo.
English: IONSYS should not be placed on abnormal skin sites, such as scars, burns, tattoos, etc. IONSYS should also not be placed on skin on which topical medicines have been applied.
Slovenian: Zdravilo IONSYS se ne sme namestiti na nenormalna mesta na koži, kot so brazgotine, opekline, tetovaže ipd. Ne sme se namestiti na kožne predele, na katerih so bila uporabljena zdravila za topikalno uporabo.
English: • Press IONSYS firmly in place for at least 15 seconds with the sticky side down on the skin of the chest or upper arm of the patient.
Slovenian: • Sistem IONSYS za najmanj 15 sekund trdno pritisnite z lepilno stranjo navzdol na kožo na bolnikovih prsih ali nadlahti.
English: Do not drink alcohol or grapefruit juice whilst you are wearing IONSYS because it can increase the risk of experiencing dangerous side effects.
Slovenian: Zdravilo IONSYS skupaj s hrano, pijačo in alkoholom Ne pijte alkohola ali soka grenivke, medtem ko nosite sistem IONSYS, ker lahko povečata tveganje za pojav nevarnih neželenih učinkov.
English: Clinical relevance is unknown from these published articles; however, caution should be used if administering IONSYS in patients with genetic polymorphisms of CYP3A4 and CYP3A5 (see section 4.4).
Slovenian: Iz objavljenih člankov ni mogoče razbrati klinične pomembnosti, vendar je pri dajanju zdravila IONSYS bolnikom z genetskima polimorfizmoma CYP3A4 in CYP3A5 potrebna previdnost (glejte poglavje 4.4).
English: Instructing the patient how to use IONSYS
Slovenian: Poučitev bolnika o uporabi sistema IONSYS
English: The drug unit is blue on the side that connects to the controller and has a red bottom housing containing the hydrogels, one of which contains the fentanyl hydrochloride.
Slovenian: Zdravilna enota je modre barve na strani, ki se poveže z upravljalnikom, v rdečem spodnjem delu ohišja pa vsebuje hidrogela, od katerih eden vsebuje fentanilov hidroklorid.
English: Elderly patients should be observed carefully for adverse effects of fentanyl during IONSYS administration (see sections 4.2 and 4.8).
Slovenian: Starejše bolnike je treba med uporabo zdravila IONSYS pozorno spremljati zaradi neželenih učinkov fentanila (glejte poglavji 4.2 in 4.8).
English: • constipation, stomach pain
Slovenian: • zaprtost, bolečine v trebuhu
English: If additional opioid analgesia is required, a new IONSYS should be applied to a different skin site, after removal and disposal of the previous IONSYS.
Slovenian: Če je potrebna dodatna opioidna analgezija, morate po odstranitvi in odlaganju prejšnjega sistema IONSYS namestiti novega na drug kožni predel.
English: IONSYS is used in hospital only.
Slovenian: Sistem IONSYS se lahko uporablja samo v bolnišnicah.
English: If device failure or malfunction is suspected by a healthcare professional, IONSYS should be immediately removed from the patient and The Medicines Company contacted straightaway.
Slovenian: Če zdravstveni delavec sumi, da je sistem IONSYS okvarjen ali da ne deluje pravilno, ga mora takoj odstraniti z bolnika in stopiti v stik z družbo The Medicines Company.
English: IONSYS is designed so that you can't use too much, provided that only you operate it, and that only you use it when you need pain relief.
Slovenian: Če ste uporabili večji odmerek zdravila IONSYS, kot bi smeli Sistem IONSYS je zasnovan tako, da ne morete uporabiti preveč zdravila, vendar ga morate upravljati sami in samo, kadar potrebujete lajšanje bolečin.
English: Name and address of the manufacturer responsible for batch release Penn Pharmaceutical Services Ltd 23-24 Tafarnaubach Industrial Estate Tredegar
Slovenian: Penn Pharmaceutical Services Ltd 23-24 Tafarnaubach Industrial Estate Tredegar
English: Prolonged treatment with fentanyl, the active substance in IONSYS, may cause withdrawal symptoms in the newborn baby.
Slovenian: Po dolgoročnem zdravljenju lahko fentanil, zdravilna učinkovina v zdravilu IONSYS, povzroči odtegnitvene simptome pri novorojencu.
English: The drug unit is blue on the side that connects to the controller and has a red bottom housing containing the hydrogels, one of which contains the fentanyl.
Slovenian: Zdravilna enota je modra na strani, ki se poveže z upravljalnikom, v rdečem spodnjem delu ohišja pa vsebuje dva hidrogela, od katerih eden vsebuje fentanil.
English: Patients with hepatic impairment should be observed carefully for signs of fentanyl toxicity.
Slovenian: Bolnike z okvaro jeter je treba skrbno opazovati glede znakov toksičnosti fentanila.
English: • passing water (urinating) less frequently than normal • passing wind, difficulty passing stools
Slovenian: • manj pogosto odvajanje vode (uriniranje) kot običajno
English: • Continuous blinking red light
Slovenian: • rdeča lučka neprekinjeno utripa
English: These actions can be followed by administration of a specific opioid antagonist such as naloxone, based on the clinical judgment of the treating health care professional.
Slovenian: Tem ukrepom lahko na podlagi klinične presoje lečečega zdravnika sledi dajanje specifičnega opioidnega antagonista, kot je nalokson.
English: Place a new system on a different skin site.
Slovenian: Namestite nov sistem na drug kožni predel.