FrancophonIA/ELRC3.0 huggingface dataset:
English: Glimepiride was initiated at 1 mg/day and titrated up to a maximum dose of 6 or 8 mg/day (depending on maximum approved dose in each country) or a maximum tolerated dose or down-titrated to avoid or manage hypoglycaemia.
Croatian: Glimepirid je uveden u dozi od 1 mg na dan, koja se titrirala do maksimalne doze od 6 ili 8 mg na dan (ovisno o maksimalnoj odobrenoj dozi u svakoj zemlji) ili do maksimalne podnošljive doze, ili se smanjivala radi izbjegavanja ili zbrinjavanja hipoglikemije.
English: If any of the above apply to you, talk to your doctor for further instructions.
Croatian: Ako se nešto od navedenog odnosi na Vas, obratite se svom liječniku za daljnje upute.
English: You should not use Segluromet if you are pregnant.
Croatian: Nemojte uzimati Segluromet ako ste trudni.
English: A GFR should be assessed before initiation of treatment with metformin-containing products and at least annually thereafter.
Croatian: Treba ocijeniti GFR prije početka liječenja lijekovima koji sadrže metformin te najmanje jedanput godišnje nakon toga.
English: If necessary, the dose of the antihyperglycaemic medicinal product should be adjusted during therapy with the other medicinal product and on its discontinuation.
Croatian: Ako je potrebno, dozu antihiperglikemijskog lijeka treba prilagoditi tijekom liječenja drugim lijekom i nakon prekida takvog liječenja.
English: Glucocorticoids (given by systemic and local routes), beta 2 agonists, and diuretics have intrinsic hyperglycaemic activity.
Croatian: Glukokortikoidi (primijenjeni sistemskim i lokalnim putem), beta-2 agonisti i diuretici imaju intrinzičku hiperglikemijsku aktivnost.
English: • blood tests may show changes in the amount of total and bad cholesterol (called LDL - a type of fat in your blood)
Croatian: • nalazi krvnih pretraga mogu pokazivati promjene u količini ukupnog i lošeg kolesterola (koji se zove LDL kolesterol - jedna vrsta masnoća u krvi)
English: These symptoms could be a sign of “diabetic ketoacidosis”a problem you can get with diabetes because of increased levels of “ketone bodies” in your urine or blood, seen in tests.
Croatian: Ti simptomi mogu biti znakovi „dijabetičke ketoacidoze“ - problema koji se može javiti kod šećerne bolesti zbog povišenih razina „ketonskih tijela“ u mokraći ili krvi, koje su vidljive u nalazima pretraga.
English: Segluromet may cause a very rare, but very serious side effect called lactic acidosis, particularly if your kidneys are not working properly.
Croatian: Segluromet može uzrokovati vrlo rijetku, ali vrlo ozbiljnu nuspojavu koja se naziva laktacidoza, osobito ako Vam bubrezi ne rade ispravno.
English: Unlike sulphonylureas, metformin does not produce hypoglycaemia in either patients with type 2 diabetes or normal subjects, except in special circumstances (see section 4.5), and does not cause hyperinsulinaemia.
Croatian: Za razliku od sulfonilureja, metformin ne izaziva hipoglikemiju ni u bolesnika s dijabetesom tipa 2 ni u zdravih ispitanika, osim u posebnim okolnostima (vidjeti dio 4.5) te ne uzrokuje hiperinzulinemiju.
English: Ertugliflozin increases the risk of genital mycotic infections.
Croatian: Ertugliflozin povećava rizik od genitalnih gljivičnih infekcija.
English: • have or have had yeast infections of the vagina or penis.
Croatian: • ako imate ili ste imali gljivičnu infekciju rodnice ili penisa,
English: Temporary interruption of treatment with Segluromet should be considered until the fluid loss is corrected.
Croatian: Treba razmotriti privremeni prekid liječenja lijekom Segluromet dok se gubitak tekućine ne korigira.
English: Symptoms include stomach pain, fast and deep breathing, sleepiness, or your breath developing an unusual fruity smell.
Croatian: Simptomi uključuju bol u trbuhu, ubrzano i duboko disanje, pospanost ili Vam dah ima neobičan voćni miris,
English: Do not take Segluromet
Croatian: Nemojte uzimati Segluromet
English: Patients 65 years and older treated with ertugliflozin had a higher incidence of adverse reactions related to volume depletion compared to younger patients.
Croatian: Bolesnici u dobi od 65 i više godina liječeni ertugliflozinom imali su veću incidenciju nuspojava povezanih s deplecijom volumena u usporedbi s mlađim bolesnicima.
English: Do not drive or use any tools or machines if you feel dizzy while taking Segluromet.
Croatian: Nemojte upravljati vozilima, rukovati alatima niti raditi sa strojevima ako osjećate omaglicu dok uzimate Segluromet.
English: CYP-mediated (oxidative) metabolism of ertugliflozin is minimal (12%).
Croatian: Metabolizam ertugliflozina posredovan CYP enzimima (oksidacijski metabolizam) je minimalan (12%).
English: Avoid excessive alcohol intake while taking Segluromet since this may increase the risk of lactic acidosis (see section “Warnings and precautions”).
Croatian: Izbjegavajte prekomjerni unos alkohola dok uzimate Segluromet jer to može povećati rizik od laktacidoze (pogledajte dio „Upozorenja i mjere opreza“).
English: See “Description of selected adverse reactions” for frequencies and see section 4.4.
Croatian: Vidjeti „Opis odabranih nuspojava“ za učestalost i vidjeti dio 4.4.
English: As precautionary measures, consideration should be given to carefully monitoring patients with a higher risk for amputation events and counselling patients about the importance of routine preventative foot care and maintaining adequate hydration.
Croatian: Kao mjere opreza, potrebno je razmotriti pažljivo praćenje bolesnika s većim rizikom od amputacije te savjetovanje bolesnika o važnosti rutinske preventivne njege stopala i održavanja primjerene hidracije.
English: The safety and efficacy of Segluromet in patients with type 1 diabetes have not been established and Segluromet should not be used for treatment of patients with type 1 diabetes.
Croatian: Sigurnost i djelotvornost lijeka Segluromet u bolesnika s dijabetesom tipa 1 nisu ustanovljene, pa se Segluromet ne smije primjenjivati za liječenje bolesnika s dijabetesom tipa 1.
English: The incidence and type of adverse reactions in these two trials were similar to the adverse reactions seen with ertugliflozin.
Croatian: Incidencija i vrsta nuspojava u ta dva ispitivanja bile su slične onima opaženima kod primjene ertugliflozina.
English: There is limited experience with Segluromet in patients ≥ 75 years of age.
Croatian: Iskustvo s primjenom lijeka Segluromet u bolesnika u dobi od ≥ 75 godina je ograničeno.
English: Ertugliflozin and metformin are present in the milk of lactating rats.
Croatian: Ertugliflozin i metformin prisutni su u mlijeku ženki štakora u laktaciji.
English: Organic cation transporters (OCT) Metformin is a substrate of both transporters OCT1 and OCT2.
Croatian: Prijenosnici organskih kationa (engl. organic cation transporters, OCT) Metformin je supstrat oba prijenosnika OCT1 i OCT2.
English: Stop taking Segluromet for a short time if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal.
Croatian: Prestanite nakratko uzimati Segluromet ako imate stanje koje može biti povezano s dehidracijom (značajan gubitak tjelesnih tekućina), kao što je jako povraćanje, proljev, vrućica, izloženost vrućini ili ako pijete manje tekućine nego obično.
English: Segluromet should not be used to treat this condition.
Croatian: Segluromet se ne smije koristiti za liječenje te bolesti,
English: A clinically relevant effect with other inducers (e.g., carbamazepine, phenytoin, phenobarbital) is not expected.
Croatian: Ne očekuje se klinički značajan učinak kod primjene drugih induktora (npr. karbamazepina, fenitoina, fenobarbitala).
English: You may be more likely to get dehydrated if you:
Croatian: Vjerojatnost dehidracije veća je:
English: • The recommended dose of Segluromet is one tablet twice a day.
Croatian: • Preporučena doza lijeka Segluromet je jedna tableta dvaput na dan.
English: Pregnancy There are no data from the use of Segluromet in pregnant women.
Croatian: Trudnoća Nema podataka o primjeni lijeka Segluromet u trudnica.
English: In a number of cases, the presentation of the condition was atypical with only moderately increased blood glucose values, below 14 mmol/l (250 mg/dl).
Croatian: U brojnim se slučajevima stanje očitovalo atipično, uz samo umjereno povišene vrijednosti glukoze u krvi, niže od 14 mmol/l (250 mg/dl).
English: • have ever had serious heart disease or if you have had a stroke.
Croatian: • ako ste ikada imali ozbiljnu srčanu bolest ili ste pretrpjeli moždani udar,
English: The blood-to-plasma concentration ratio of ertugliflozin is 0.66.
Croatian: Omjer koncentracije ertugliflozina u krvi i plazmi iznosi 0,66.
English: Necrotising fasciitis of the perineum (Fournier's gangrene)*
Croatian: nekrotizirajući fasciitis perineuma (Fournierova gangrena)*
English: If this happens, you must stop taking Segluromet and contact a doctor or the nearest hospital immediately, as lactic acidosis may lead to coma.
Croatian: Ako se to dogodi, morate prestati uzimati Segluromet i odmah se obratiti liječniku ili otići u najbližu bolnicu, jer laktacidoza može dovesti do kome.
English: What Segluromet is and what it is used for
Croatian: Što je Segluromet i za što se koristi
English: Gastrointestinal symptoms such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite occur most frequently during initiation of therapy and resolve spontaneously in most cases.
Croatian: Gastrointestinalni simptomi kao što su mučnina, povraćanje, proljev, bol u abdomenu i gubitak teka najčešće se javljaju prilikom započinjanja liječenja i u većini se slučajeva spontano povlače.
English: Lactic acidosis, a very rare but serious metabolic complication, most often occurs at acute worsening of renal function or cardiorespiratory illness or sepsis.
Croatian: Laktacidoza, vrlo rijetka ali ozbiljna metabolička komplikacija, najčešće nastaje pri akutnom pogoršanju funkcije bubrega ili kardiorespiratornoj bolesti ili sepsi.
English: • Segluromet lowers blood sugar levels in adult patients (aged 18 years and older) with type 2
Croatian: • Segluromet snižava razinu šećera u krvi u odraslih bolesnika (u dobi od 18 ili više godina) koji boluju od šećerne bolesti tipa 2.
English: • a sweet smell to your breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat
Croatian: • slatkast zadah, sladak ili metalan okus u ustima ili izmijenjen miris mokraće ili znoja.
English: SGLT2 is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation.
Croatian: SGLT2 je glavni prijenosnik odgovoran za reapsorpciju glukoze iz glomerularnog filtrata natrag u cirkulaciju.
English: • if you are taking medicines which increase urine production (diuretics).
Croatian: • ako uzimate lijekove koji povećavaju proizvodnju mokraće (diuretike),
English: Segluromet is available in Alu/PVC/PA/Alu blisters.
Croatian: Segluromet dolazi u Al/PVC/PA/Al blisterima.
English: Segluromet contains two active substances, ertugliflozin and metformin.
Croatian: Segluromet sadrži dvije djelatne tvari, ertugliflozin i metformin.
English: Metformin is dialyzable with a clearance of up to 170 ml/min under good haemodynamic conditions.
Croatian: Metformin se iz tijela može ukloniti dijalizom, uz klirens do 170 ml/min pod dobrim hemodinamičkim uvjetima.
English: In case of dehydration (severe vomiting, diarrhoea, fever or reduced fluid intake), metformin should be temporarily discontinued and contact with a health care professional is recommended.
Croatian: U slučaju dehidracije (teško povraćanje, proljev, vrućica ili smanjen unos tekućine), potrebno je privremeno prekinuti primjenu metformina i preporučuje se obratiti se zdravstvenom radniku.
English: • have type 1 diabetes.
Croatian: • ako imate šećernu bolest tipa 1.
English: Pharmacotherapeutic group: Drugs used in diabetes, combinations of oral blood glucose lowering drugs, ATC code: A10BD23.
Croatian: Farmakoterapijska skupina: Lijekovi za liječenje šećerne bolesti, kombinacije oralnih lijekova za snižavanje glukoze u krvi, ATK oznaka: A10BD23
English: • changes in urination, including urgent need to urinate more often, in larger amounts, or at night
Croatian: • promjene u mokrenju, uključujući učestalu hitnu potrebu za mokrenjem, mokrenje većih količina mokraće ili mokrenje noću
English: Across the four studies, the racial distribution ranged from 66.2% to 80.3% White, 10.6% to 20.3% Asian, 1.9% to 10.3% Black, and 4.5% to 7.4% other.
Croatian: U ta je četiri ispitivanja raspodjela ispitanika po rasama uključivala 66,2% do 80,3% bijelaca, 10,6% do 20,3% Azijaca, 1,9% do 10,3% crnaca te 4,5% do 7,4% pripadnika drugih rasa.
English: If Fournier's gangrene is suspected, Segluromet should be discontinued and prompt treatment (including antibiotics and surgical debridement) should be instituted.
Croatian: Ako se sumnja na Fournierovu gangrenu, potrebno je prekinuti uzimanje lijeka Segluromet te hitno započeti s liječenjem (uključujući antibiotike i kirurški debridman).
English: From these data, it appears that the change in metformin pharmacokinetics with aging is primarily accounted for by a change in renal function.
Croatian: S obzirom na te podatke, čini se da je promjena farmakokinetike metformina s povećanjem dobi prvenstveno posljedica promjene funkcije bubrega.
English: p< 0.001 compared to glimepiride.
Croatian: p < 0,001 u odnosu na glimepirid.
English: • reduced body temperature and heartbeat Lactic acidosis is a medical emergency and must be treated in a hospital.
Croatian: • sniženu tjelesnu temperaturu i usporen rad srca Laktacidoza je hitno medicinsko stanje i mora se liječiti u bolnici.
English: Metformin did not adversely affect developmental outcomes when administered to rats and rabbits at doses up to 600 mg/kg/day.
Croatian: Metformin nije negativno utjecao na ishode razvoja kada se primjenjivao štakorima i kunićima u dozama do 600 mg/kg na dan.
English: If no adequate strength of Segluromet is available, individual monocomponents should be used instead of the fixed-dose combination.
Croatian: Ako nije dostupna odgovarajuća jačina lijeka Segluromet, umjesto fiksne kombinacije treba primijeniti pojedinačne sastavnice.
English: Male genital mycotic infections occurred more commonly in uncircumcised males.
Croatian: Genitalne gljivične infekcije češće su se javljale u neobrezanih muškaraca.
English: p< 0.001 compared to placebo (based on adjusted odds ratio comparisons from a logistic regression model using multiple imputation for missing data values).
Croatian: p < 0,001 u odnosu na placebo (na temelju usporedbi prilagođenih omjera izgleda iz modela logističke regresije u kojima su se koristili višestruki unosi za vrijednosti podataka koji nedostaju).
English: Some medicinal products can adversely affect renal function, which may increase the risk of lactic acidosis, e.g., NSAIDs, including selective cyclo-oxygenase (COX) II inhibitors, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists and diuretics, especially loop diuretics.
Croatian: Neki lijekovi mogu štetno utjecati na funkciju bubrega, što može povećati rizik od laktacidoze, npr. NSAIL-ovi, uključujući selektivne inhibitore ciklooksigenaze (engl. cyclo-oxygenase, COX) II, inhibitori angiotenzin-konvertirajućeg enzima (engl. angiotensin-converting enzyme, ACE), antagonisti receptora angiotenzina II i diuretici, osobito diuretici Henleove petlje.
English: • Ertugliflozin works by blocking the SGLT2 protein in your kidneys.
Croatian: • Ertugliflozin djeluje tako da blokira protein SGLT2 u bubrezima.
English: Balanitis candida and other male genital mycotic infections*
Croatian: kandidni balanitis i druge genitalne gljivične infekcije u muškaraca*
English: Segluromet has no or negligible influence on the ability to drive and use machines.
Croatian: Segluromet ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Assess renal function more frequently in elderly patients.
Croatian: Češće kontrolirajte funkciju bubrega u starijih bolesnika.
English: The mean age of the patients across these four studies ranged from 55.1 to 59.1 years (range 21 years to 86 years); 15.6% to 29.9% of patients were ≥65 years of age and 0.6% to 3.8% were ≥75 years of age.
Croatian: Srednja vrijednost dobi bolesnika u ta četiri ispitivanja kretala se od 55,1 do 59,1 godinu (raspon: 21 - 86 godina); 15,6 do 29,9% bolesnika bilo je u dobi od ≥ 65 godina, dok je 0,6 do 3,8% njih bilo u dobi od ≥ 75 godina.
English: Because of how Segluromet works, your urine will test positive for sugar (glucose) while you are on this medicine.
Croatian: Zbog načina na koji lijek Segluromet djeluje, nalazi pretraga mokraće bit će pozitivni na šećer (glukozu) dok uzimate ovaj lijek.
English: Renal function and risk of volume depletion should be taken into account (see sections 4.4 and 4.8).
Croatian: Treba uzeti u obzir funkciju bubrega i rizik od deplecije volumena (vidjeti dijelove 4.4 i 4.8).
English: Results in the in vivo mouse micronucleus test were also negative.
Croatian: Nalazi mikronukleusnog testa na miševima in vivo također su bili negativni.
English: Paediatric population No studies with ertugliflozin have been performed in paediatric patients.
Croatian: Pedijatrijska populacija Nisu provedena ispitivanja ertugliflozina u pedijatrijskih bolesnika.
English: Animal studies with metformin do not indicate harmful effects with respect to pregnancy, embryonic or foetal development, parturition or post-natal development (see section 5.3).
Croatian: Ispitivanja metformina na životinjama nisu pokazala štetne učinke na trudnoću, razvoj embrija i fetusa, porod i postnatalni razvoj (vidjeti dio 5.3).
English: • if you are taking other medicines that lower the sugar in your blood, such as insulin or medicines that increase insulin release from the pancreas.
Croatian: • ako uzimate druge lijekove koji snižavaju razinu šećera u krvi, kao što su inzulin ili lijekovi koji pojačavaju oslobađanje inzulina iz gušterače,
English: Diagnostic laboratory findings are decreased blood pH (< 7.35), increased plasma lactate levels (> 5 mmol/l) and an increased anion gap and lactate/pyruvate ratio.
Croatian: Dijagnostički laboratorijski nalazi pokazuju snižen pH krvi (< 7,35), povišene razine laktata u plazmi (> 5 mmol/l) te povećan anionski procijep i omjer laktata i piruvata.
English: Stop taking Segluromet and contact a doctor or the nearest hospital immediately if you experience some of the symptoms of lactic acidosis, as this condition may lead to coma.
Croatian: Prestanite uzimati Segluromet i odmah se obratite liječniku ili otiđite u najbližu bolnicu ako osjetite neke od simptoma laktacidoze, jer to stanje može dovesti do kome.
English: Initial increases in mean creatinine and decreases in mean eGFR in patients treated with ertugliflozin were generally transient during continuous treatment.
Croatian: Početna povišenja srednje vrijednosti kreatinina i smanjenja srednje vrijednosti eGFR-a u bolesnika liječenih ertugliflozinom obično su bila prolazna tijekom kontinuiranog liječenja.
English: Lactic acidosis (very rare, may affect up to 1 in 10,000 people) Segluromet may cause a very rare, but very serious side effect called lactic acidosis (see section “Warnings and precautions”).
Croatian: Laktacidoza (vrlo rijetko, može se javiti u do 1 na 10 000 osoba) Segluromet može uzrokovati vrlo rijetku, ali vrlo ozbiljnu nuspojavu koja se naziva laktacidoza (pogledajte dio „Upozorenja i mjere opreza“).
English: In patients with volume depletion, correcting this condition prior to initiation of Segluromet is recommended (see section 4.4).
Croatian: U bolesnika s deplecijom volumena preporučuje se korigirati to stanje prije uvođenja lijeka Segluromet (vidjeti dio 4.4).
English: Insulin and insulin secretagogues, such as sulphonylureas, cause hypoglycaemia.
Croatian: Inzulin i inzulinski sekretagozi, poput sulfonilureje, izazivaju hipoglikemiju.
English: Moderate hepatic impairment (based on the Child-Pugh classification) did not result in an increase in exposure of ertugliflozin.
Croatian: Umjereno oštećenje funkcije jetre (prema Child-Pugh klasifikaciji) nije povećalo izloženost ertugliflozinu.
English: • if you have severely reduced kidney function or need dialysis.
Croatian: • ako imate jako smanjenu funkciju bubrega ili Vam je potrebna dijaliza,
English: Your doctor may reduce the dose of your insulin or other medicine.
Croatian: Liječnik će Vam možda smanjiti dozu inzulina ili drugih lijekova.
English: Discontinue when GFR is persistently less than 45 ml/min.
Croatian: Prekinuti primjenu kada je GFR trajno manji od 45 ml/min.
English: There was no evidence of a mutagenic potential of metformin in the following in vitro tests: Ames test (S. typhimurium), gene mutation test (mouse lymphoma cells), or chromosomal aberrations test (human lymphocytes).
Croatian: Nisu pronađeni dokazi mutagenog potencijala metformina u sljedećim testovima in vitro: Amesovu testu (S. typhimurium), testu genske mutacije (stanice mišjeg limfoma) ni testu kromosomskih aberacija (ljudski limfociti).
English: Most toxicity was consistent with pharmacology related to urinary glucose loss and included decreased body weight and body fat, increased food consumption, diarrhoea, dehydration, decreased serum glucose and increases in other serum parameters reflective of increased protein metabolism, gluconeogenesis and electrolyte imbalances, and urinary changes such as polyuria, glucosuria, and calciuria.
Croatian: Glavnina toksičnosti bila je u skladu s farmakologijom povezanom s gubitkom glukoze mokraćom, a uključivala je smanjenje tjelesne težine i udjela masnoće u tijelu, povećanu konzumaciju hrane, proljev, dehidraciju, snižene vrijednosti glukoze u serumu i povišenja drugih serumskih parametara koji odražavaju pojačan metabolizam proteina, glukoneogenezu i neravnotežu elektrolita, te promjene u mokraći, kao što su poliurija, glukozurija i kalciurija.
English: Packs of 30x1 film-coated tablets in perforated unit dose blisters.
Croatian: Pakiranja od 30 x 1 filmom obložene tablete u perforiranim blisterima s jediničnim dozama.
English: Ertugliflozin was a weak inhibitor of UGTs 1A1 and 1A4 in vitro at higher concentrations that are not clinically relevant.
Croatian: Ertugliflozin je bio slab inhibitor UGT enzima 1A1 i 1A4 in vitro pri višim koncentracijama koje nisu klinički relevantne.
English: Restarting SGLT2 inhibitor treatment in patients with previous DKA while on SGLT2 inhibitor treatment is not recommended, unless another clear precipitating factor is identified and resolved.
Croatian: Ne preporučuje se ponovno uvoditi liječenje inhibitorom SGLT2 u bolesnika koji su prethodno doživjeli DKA tijekom liječenja inhibitorom SGLT2, osim ako se ne utvrdi i ukloni neki drugi očiti precipitirajući faktor.
English: During controlled clinical trials of metformin, maximum metformin plasma levels did not exceed 5 µg/mL, even at maximum doses.
Croatian: Tijekom kontroliranih kliničkih ispitivanja metformina, najviše vrijednosti metformina u plazmi nisu čak ni pri najvećim dozama prelazile 5 µg/ml.
English: Taking this medicine in combination with insulin or medicines that increase insulin release from the pancreas can cause blood sugar levels to drop too low (hypoglycaemia), which may cause symptoms such as shaking, sweating and change in vision, and may affect your ability to drive and use machines.
Croatian: Uzimanje ovoga lijeka u kombinaciji s inzulinom ili lijekovima koji pospješuju oslobađanje inzulina iz gušterače može uzrokovati pad šećera u krvi do preniskih razina (hipoglikemija), što može izazvati simptome poput drhtanja, znojenja i promjena vida te utjecati na Vašu sposobnost upravljanja vozilima i rada sa strojevima.
English: In controlled clinical studies of metformin in patients with type 2 diabetes, the antihyperglycaemic effect was comparable in Whites (n=249), Blacks (n=51), and Hispanics (n=24).
Croatian: U kontroliranim kliničkim ispitivanjima metformina provedenima u bolesnika s dijabetesom tipa 2, antihiperglikemijski učinak bio je usporediv u bijelaca (n=249), crnaca (n=51) i bolesnika hispanoameričkog podrijetla (n=24).