FrancophonIA/ELRC3.0 huggingface dataset:
English: Efavirenz plasma exposure may be increased in patients with homozygous G516T genetic variant of the CYP2B6 isozyme.
Danish: Plasmaeksponering af efavirenz kan øges hos patienter med homozygot-G516T, der er en genetisk variant af CYP2B6-isozymet.
English: A similar reduction in indinavir exposures was observed when indinavir 1,000 mg q8h was given with efavirenz 600 mg q.d.
Danish: Der sås en lignende reduktion i eksponeringen af indinavir, når indinavir 1.000 mg q8t blev givet sammen med efavirenz 600 mg q.d.
English: Write the date the bottle was opened on the label and/or carton in the space provided.
Danish: Noter datoen for tabletbeholderåbningen på etiketten og/eller pakningen på det angivne sted.
English: Approximately 14 to 34% of a radiolabelled dose of efavirenz was recovered in the urine and less than 1% of the dose was excreted in urine as unchanged efavirenz.
Danish: Ca. 14-34% af en isotopmærket dosis efavirenz blev genfundet i urinen, og mindre end 1% af dosis blev udskilt i urinen som uomdannet efavirenz.
English: The mean plasma to blood concentration ratio was approximately 1.0 and the mean semen to plasma concentration ratio was approximately 4.0.
Danish: Den gennemsnitlige koncentrationsratio af plasma/blod var ca. 1,0, og den gennemsnitlige koncentrationsratio af sæd/plasma var ca. 4,0.
English: Rosuvastatin is largely excreted unchanged via the faeces, therefore interaction with efavirenz is not expected.
Danish: Rosuvastatin udskilles primært uomdannet via fæces, og derfor forventes der ingen interaktion med efavirenz.
English: - Bupropion, a medicine used to treat depression or to help you stop smoking, as your doctor may need to change your dose of bupropion.
Danish: - Bupropion, medicin til behandling af depression eller til at hjælpe Dem med at holde op med at ryge, fordi Deres læge kan finde det nødvendigt at ændre Deres bupropion-dosis.
English: This medicinal product contains 7.5 mg of sodium metabisulfite per dose, which may rarely cause severe hypersensitivity reactions and bronchospasm.
Danish: Dette lægemiddel indeholder 7,5 mg natriummetabisulfit pr. dosis, som i sjældne tilfælde kan forårsage alvorlige overfølsomhedsreaktioner og bronkospasmer.
English: Medicinal product by therapeutic areas
Danish: Lægemidler i henhold til terapeutiske områder
English: - Medicines used to lower blood fats (also called statins): Atorvastatin, pravastatin, simvastatin.
Danish: - Medicin til nedsættelse af fedtindholdet i blodet (kaldet statiner): Atorvastatin, pravastatin, simvastatin.
English: EXP: Once opened use within 60 days.
Danish: EXP: Skal anvendes inden for 60 dage efter anbrud.
English: No malformations were observed in foetuses from efavirenz-treated rats and rabbits.
Danish: Der sås ingen misdannelser hos fostre fra efavirenz-behandlede rotter og kaniner.
English: Administration of efavirenz capsules with a high fat meal increased the mean AUC and Cmax of efavirenz by 28% and 79%, respectively, compared to administration in a fasted state.
Danish: Administration af efavirenz-kapsler sammen med et måltid med stort fedtindhold forhøjede gennemsnitligt AUC og Cmax af efavirenz med henholdsvis 28% og 79% sammenlignet med administration under faste.
English: Pack size: 30 tablets
Danish: Pakningsstørrelse: 30 tabletter
English: For lipids, there is in some cases evidence for a treatment effect, while for weight gain there is no strong evidence relating this to any particular treatment.
Danish: For lipider er der i visse tilfælde fundet evidens for en behandlingvirkning, mens der ikke er tydelig evidens for relation mellem vægtøgning og en specifik behandling.
English: Sufficient data on the tolerability of efavirenz with low-dose ritonavir (100 mg, once or twice daily) are not available.
Danish: Der foreligger ikke tilstrækkelige data vedrørende tolerabiliteten af efavirenz sammen med ritonavir i lav dosis (100 mg én eller to gange dagligt).
English: For monitoring of blood lipids and glucose reference is made to established HIV treatment guidelines.
Danish: Med hensyn til monitorering af lipider og glucose i blodet refereres til eksisterende retningslinjer for behandling af hiv.
English: Efavirenz demonstrated antiviral activity against most non-clade B isolates (subtypes A, AE, AG, C, D, F, G, J, and N) but had reduced antiviral activity against group O viruses.
Danish: Efavirenz udviste antiviral aktivitet mod de fleste nongruppe-B-isolater (undergrupper A, AE, AG, C, D, F, G, J og N), men havde reduceret antiviral aktivitet mod gruppe-O-vira.
English: Mylan Hungary Kft Mylan utca 1, Komárom 2900, Hungary
Danish: Mylan Hungary Kft Mylan utca 1, Komárom 2900, Ungarn
English: • allergic reactions
Danish: Allergisk reaktion
English: • liver and pancreas problems • increased fatty acids (triglycerides), bilirubin or sugar levels in the blood
Danish: • Forhøjet indhold af fedtsyrer (triglycerider), bilirubin eller sukker i blodet
English: Patients either changed to efavirenz/emtricitabine/tenofovir disoproxil (N=203) or continued on their original antiretroviral treatment regimen (N=97).
Danish: Patienterne blev enten skiftet til efavirenz/emtricitabin/tenofovirdisoproxil (n=203) eller fortsatte med deres oprindelige antiretrovirale behandlingsregimen (n=97).
English: Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Danish: Overfølsomhed over for aktive emner eller over for nogen af hjælpestofferne fremgår af pkt 6.1.
English: See ritonavir row below.
Danish: Se ritonavir-rækken nedenfor.
English: - Independent of a history of liver disease, your doctor will consider regular blood tests to check how your liver is working.
Danish: - Uanset om De tidligere har haft en leversygdom, vil Deres læge overveje at tage regelmæssige blodprøver for at kontrollere, hvordan Deres lever fungerer.
English: Resistance analysis by week 144 On-therapy genotypes Efavirenz resistance1
Danish: Resistensanalyse i uge 144 Behandlingsgenotyper Efavirenz-resistens1 K103N
English: These patients should be carefully monitored for efavirenz adverse reactions, especially nervous system symptoms.
Danish: Disse patienter skal monitoreres omhyggeligt med henblik på efavirenz-bivirkninger, især symptomer fra nervesystemet.
English: HIV/HBV or HCV co-infected patients: Only a limited number of patients were co-infected with HBV (n = 13) or HCV (n = 26) in study GS-01-934.
Danish: Patienter som samtidigt er inficerede med hiv+HBV eller hiv+hcv: Det var kun et begrænset antal patienter, som samtidigt var inficerede med HBV (n=13) eller hcv (n=26) i studie GS-01-934.
English: Laboratory tests should be performed to evaluate their liver disease at periodic intervals (see section 4.2).
Danish: Der skal regelmæssigt udføres laboratorietests til evaluering af deres leversygdom (se pkt.
English: After 96 weeks of efavirenz/emtricitabine/tenofovir disoproxil treatment, HIV-1 RNA plasma concentrations remained < 50 copies/ml in 82% of patients and < 400 copies/ml in 85% of patients (intention to treat analysis (ITT), missing=failure).
Danish: Efter 96 uger med behandling med efavirenz/emtricitabin/tenofovirdisoproxil forblev hiv-1-rnaplasmakoncentrationerne < 50 kopier/ml hos 82% af patienterne og < 400 kopier/ml hos 85% af patienterne (intention to treat-analyse (ITT), missing = failure).
English: Patients should be advised that if they experience symptoms such as severe depression, psychosis or suicidal ideation, they should contact their doctor immediately to assess the possibility that the symptoms may be related to the use of efavirenz, and if so, to determine whether the risk of continued therapy outweighs the benefits (see section 4.8).
Danish: Patienterne skal rådes til straks at kontakte deres læge, hvis de oplever symptomer som svær depression, psykose eller selvmordstanker, med henblik på vurdering af, om symptomerne er relateret til brugen af efavirenz, og hvis dette er tilfældet, for at beslutte hvorvidt risici ved fortsat behandling overstiger fordelene (se pkt.
English: If you have taken Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Danish: Hvis De har taget Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan under Deres graviditet, kan lægen anmode om regelmæssige blodprøver og andre diagnostiske undersøgelser for at overvåge barnets udvikling.
English: The potential for cross-resistance between efavirenz and NRTIs is low because of the different binding sites on the target and mechanism of action.
Danish: Risikoen for krydsresistens mellem efavirenz og NRTI'er er lille på grund af de forskellige bindingssteder og virkningsmekanismen.
English: Co-administration with drugs that are known to prolong the QTc interval (proarryhthmic).
Danish: Samtidig administration med lægemidler, som vides at forlænge QTc-intervallet (proarytmika).
English: The following side effects may be signs of lactic acidosis: - deep rapid breathing - drowsiness - feeling sick (nausea), being sick (vomiting) and stomach pain.
Danish: Følgende bivirkninger kan være tegn på laktatacidose: - Dyb, hurtig vejrtrækning - Træthed - Kvalme, opkastning og mavesmerter.
English: Both emtricitabine triphosphate and tenofovir diphosphate are weak inhibitors of mammalian DNA polymerases and there was no evidence of toxicity to mitochondria in vitro and in vivo.
Danish: Både emtricitabintrifosfat og tenofovirdifosfat er svage hæmmere af mammale dna-polymeraser, og der var intet tegn på toksicitet over for mitokondrier in vitro og in vivo.
English: Stevens-Johnson syndrome, erythema multiforme3, severe rash angioedema4
Danish: Stevens-Johnsons syndrom, erythema multiforme3, svært udslæt
English: Cmax: ↔ 11% (CYP3A induction - effect on boceprevir) *0-8 hours
Danish: Cmax: ↔ 11% (CYP3A-induktion - virkning på boceprevir) *0-8 timer
English: - Medicines used to treat bacterial infections, including tuberculosis and AIDS-related mycobacterium avium complex: Clarithromycin, rifabutin, rifampicin.
Danish: - Medicin til behandling af bakterieinfektioner, herunder tuberkulose og AIDS-relaterede mykobakterier: clarithromycin, rifabutin, rifampicin.
English: Although in vitro data suggest that efavirenz inhibits CYP2C9 and CYP2C19, there have been contradictory reports of both increased and decreased exposures to substrates of these enzymes when coadministered with efavirenz in vivo.
Danish: Selvom in vitro-data tyder på, at efavirenz hæmmer CYP2C9 og CYP2C19, har der været modsigende rapporter om både forhøjede og reducerede eksponeringer for substrater for disse enzymer in vivo, når de administreres samtidigt med efavirenz.
English: - signs of dizziness, difficulty sleeping, drowsiness, difficulty concentrating or abnormal dreaming.
Danish: - Tegn på svimmelhed, søvnbesvær, døsighed, koncentrationsbesvær eller unormale drømme.
English: A similar trend was observed in a sub-group analysis of treatment-experienced patients with baseline HIV-1 RNA < 75 copies/ml from a retrospective cohort study (data collected over 20 months, see Table 5).
Danish: En lignende tendens blev observeret i en undergruppeanalyse af behandlingserfarne patienter med hiv1-rna < 75 kopier/ml ved baseline fra et retrospektivt kohorte-studie (data indsamlet i løbet af 20 måneder, se tabel 5).
English: Patients receiving efavirenz/emtricitabine/tenofovir disoproxil or any other antiretroviral therapy may continue to develop opportunistic infections and other complications of HIV infection, and therefore should remain under close clinical observation by physicians experienced in the treatment of patients with HIV associated diseases.
Danish: Patienter, der får efavirenz/emtricitabin/tenofovirdisoproxil eller anden antiretroviral behandling, kan fortsat udvikle opportunistiske infektioner og andre hiv-relaterede komplikationer og skal derfor fortsætte under tæt klinisk observation af læger, der har erfaring med behandling af patienter med hivassocierede sygdomme.
English: Please refer to the Summary of Product Characteristics for the individual components for additional information regarding in vivo resistance with these medicinal products.
Danish: Se produktresuméerne for de individuelle komponenter med henblik på in vivo-resistens i forbindelse med disse lægemidler for at få yderligere information.
English: 1 Other efavirenz resistance mutations included A98G (n=1), K103E (n=1), V179D (n=1), and M230L (n=1).
Danish: 1 Andre efavirenz-resistensmutationer omfattede A98G (n=1), K103E (n=1), V179D (n=1) og M230L (n=1).
English: Limited clinical experience in patients co-infected with HIV and HBV suggests that treatment with emtricitabine or tenofovir disoproxil in antiretroviral combination therapy to control HIV infection also results in a reduction in HBV DNA (3 log10 reduction or 4 to 5 log10 reduction, respectively) (see section 4.4).
Danish: Begrænset klinisk erfaring hos patienter, der samtidigt er inficerede med hiv og HBV, tyder på, at behandling med emtricitabin eller tenofovirdisoproxil i antiretroviral kombinationsbehandling til kontrol af hiv-infektion også resulterer i reduktion af HBV-dna (henholdsvis 3 log10 reduktion eller 4 til 5 log10 reduktion) (se pkt 4.4).
English: If you are pregnant, you should take Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan only if you and your doctor decide it is clearly needed.
Danish: Hvis De er gravid, må De kun tage Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan, hvis De og Deres læge beslutter, at det er klart nødvendigt.
English: Emtricitabine (n=45)
Danish: Emtricitabin (N=45)
English: Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan contains three active substances that are used to treat human immunodeficiency virus (HIV) infection:
Danish: Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan indeholder tre aktive stoffer, som anvendes til at behandle human immundefektvirus- (hiv) infektion:
English: Efavirenz: There have been seven retrospective reports of findings consistent with neural tube defects, including meningomyelocele, all in mothers exposed to efavirenz-containing regimens (excluding any efavirenz-containing fixed-dose combination tablets) in the first trimester.
Danish: Efavirenz: Der har været 7 retrospektive rapporter om fund svarende til neuralrørsdefekter, herunder meningomyelocele, alle hos mødre, der i første trimester havde været eksponeret for efavirenz-holdige regimener (eksklusive efavirenz-holdige kombinationstabletter i faste doser).
English: Efavirenz non-competitively inhibits HIV-1 reverse transcriptase (RT) and does not significantly inhibit human immunodeficiency virus-2 (HIV-2) RT or cellular deoxyribonucleic acid (DNA) polymerases (α, β, γ, and δ).
Danish: Efavirenz er en nonkompetitiv hæmmer af hiv-1 revers transkriptase (RT) og hæmmer ikke signifikant human immundeficientvirus-2 (hiv-2) RT eller cellulære deoxyribonukleinsyre- (dna) polymeraser (α, β, γ og δ).
English: Pink capsule-shaped, biconvex, beveled-edge film-coated tablet, approximately 21 mm x 11 mm and debossed with ‘M' on one side and ‘TME' on the other side.
Danish: Lyserød, kapselformet, bikonveks, filmovertrukket tablet med afskåret kant, ca. 21 mm × 11 mm og præget med ‘M' på den ene side og ‘TME' på den anden side.
English: - Medicines used to treat fungal infections (antifungals): Itraconazole or posaconazole.
Danish: - Medicin til behandling af svampeinfektioner (svampemiddel): itraconazol eller posaconazol.
English: Patients with HIV-1 harbouring mutations
Danish: Patienter med hiv-1 med stammer, som har mutationer
English: Cmin: ↑ 51% (↑ 37 to ↑ 66) Higher tenofovir concentrations could potentiate tenofovirassociated adverse events, including renal disorders.
Danish: Cmin: ↑ 51% (↑ 37 til ↑ 66) Højere koncentrationer af tenofovir kan forstærke tenofovir-associerede bivirkninger, herunder nyresygdomme.
English: Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan is a treatment for Human Immunodeficiency Virus (HIV) infection in adults aged 18 years and over who have previously been treated with other antiretroviral medicines and have their HIV-1 infection under control for at least three months.
Danish: Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan er til behandling af Human ImmundefektVirus (hiv)-infektion hos voksne i alderen 18 år og derover, som tidligere er blevet behandlet med anden antiretroviral medicin, og hvis hiv-1-infektion har været under kontrol i mindst tre måneder.
English: In both studies, plasma progesterone levels for subjects receiving efavirenz and DMPA remained low consistent with suppression of ovulation.
Danish: I begge studier forblev koncentrationerne for plasmaprogesteron hos de patienter, der fik efavirenz og DMPA, lave i overensstemmelse med undertrykkelsen af ovulationen.
English: Always take this medicine exactly as your doctor or pharmacist has told you.
Danish: Tag altid lægemidlet nøjagtigt som beskrevet i denne indlægsseddel efter lægens eller apotekspersonalets anvisning.
English: In the open-label extended phase of study GS-01-934, where patients received efavirenz/emtricitabine/tenofovir disoproxil on an empty stomach, 3 additional cases of resistance were seen.
Danish: I den åbne forlængelsesfase af studie GS-01-934, hvor patienterne fik efavirenz/emtricitabin/tenofovirdisoproxil på tom mave, blev der observeret yderligere 3 tilfælde af resistens.
English: Croscarmellose sodium Hydroxypropylcellulose Low-substituted hydroxypropylcellulose Magnesium stearate
Danish: Croscarmellosenatrium Hydroxypropylcellulose Lav-substitueret hydroxypropylcellulose Magnesiumstearat
English: Patients with HIV-1 expressing three or more thymidine analogue associated mutations (TAMs) that included either an M41L or an L210W substitution in RT showed reduced susceptibility to tenofovir disoproxil.
Danish: Patienter, hvis hiv-1 udtrykte 3 eller flere tymidinanalog-forbundne mutationer (TAM'er), som omfattede enten en M41L- eller en L210W-substitution i RT, udviste reduceret følsomhed over for tenofovirdisoproxil.
English: This loss is due to significant decreases in elbasvir/grazoprevir plasma concentrations caused by CYP3A4 or P gp induction.
Danish: Dette skyldes signifikante fald i plasmakoncentrationerne af elbasvir/grazoprevir på grund af CYP3A4- eller P-gp-induktion.
English: A multiple-dose study of efavirenz showed no significant effect on efavirenz pharmacokinetics in patients with mild hepatic impairment (Child-Pugh-Turcotte Class A) compared with controls.
Danish: Et studie af efavirenz med multiple doser viste ingen signifikant påvirkning af farmakokinetikken for efavirenz hos patienter med let nedsat leverfunktion (Child-Pugh-Turcotte klasse A) sammenlignet med kontrolgruppen.
English: Table 5: Maintenance of pure virologic response (Kaplan Meier% (Standard Error) [95%CI]) at week 48 for treatment-experienced patients with baseline HIV-1 RNA < 75 copies/ml who had therapy switched to efavirenz/emtricitabine/tenofovir disoproxil according to the type of prior antiretroviral regimen (Kaiser Permanente patient database)
Danish: Tabel 5: Opretholdelse af ren virologisk respons (Kaplan Meier % (standardfejl) [95%CI]) i uge 48 hos behandlingserfarne patienter med hiv-1-rna < 75 kopier/ml ved baseline, som skiftede behandling til efavirenz/emtricitabin/tenofovirdisoproxil ifølge typen af tidligere antiretroviral behandling (Kaiser Permanente patient database)
English: Emtricitabine triphosphate and tenofovir diphosphate competitively inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.
Danish: Emtricitabintrifosfat og tenofovirdifosfat hæmmer kompetitivt hiv-1 revers transkriptase, hvilket resulterer i dna-kædeblokering.
English: The breakdown of muscle, softening of the bones (with bone pain and sometimes resulting in fractures), muscle pain, muscle weakness and decreases in potassium or phosphate in the blood may occur due to damage to kidney tubule cells.
Danish: Nedbrydning af muskelvæv, kalktab fra knoglerne (med knoglesmerter, som nogle gange resulterer i knoglebrud), muskelsmerter, muskelsvaghed og nedsat kalium- eller fosfatniveau i blodet kan forekomme på grund af skader på celler i nyrerne (de tubulære celler).
English: Uncommon rhabdomyolysis2, muscular weakness2
Danish: Rhabdomyolyse2, muskelsvækkelse2
English: Interactions between efavirenz/emtricitabine/tenofovir disoproxil or its individual component(s) and other medicinal products are listed in Table 1 below (increase is indicated as ‘↑', decrease as ‘↓', no change as ‘↔', twice daily as ‘b.i.d.
Danish: Interaktioner mellem efavirenz/emtricitabin/tenofovirdisoproxil eller dets individuelle komponent(er) og andre lægemidler ses i tabel 1 nedenfor (stigning er angivet som „↑“, fald som „↓“, ingen ændring som „↔“, to gange dagligt som „b.i.d.“, en gang dagligt som „q.d.“ og en gang hver 8. time som „q8t“).
English: Concomitant use of posaconazole and efavirenz/emtricitabine/tenofovir disoproxil should be avoided unless the benefit to the patient outweighs the risk.
Danish: Samtidig brug af posaconazol og efavirenz/emtricitabin/tenofovirdi soproxil skal undgås, medmindre fordelene for patienten overstiger risikoen.
English: If you could get pregnant while receiving Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan, you need to use a reliable form of barrier contraception (for example, a condom) with other methods of contraception including oral (pill) or other hormonal contraceptives (for example, implants, injection).
Danish: Hvis De kan blive gravid, mens De tager Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan, er det nødvendigt, at De bruger en pålidelig form for barriereprævention (f.eks. kondom) sammen med andre former for prævention, herunder P-piller eller andre hormonale præventionsmidler (f.eks. implantat, injektion).
English: Each tablet also contains 105.5 mg of lactose per tablet.
Danish: Hver dosis indeholder også 105,5 mg laktose pr. tablet.
English: - Sertraline, a medicine used to treat depression, as your doctor may need to change your dose of sertraline.
Danish: - Sertralin, medicin til behandling af depression, fordi Deres læge kan finde det nødvendigt at ændre Deres sertralin-dosis.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/17/1222/001
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/17/1222/001
English: Uncommon suicide attempt3, suicide ideation3, psychosis3, mania3, paranoia3, hallucination3, euphoric mood3, affect lability3, confusional state3, aggression3, catatonia3
Danish: Suicidalforsøg3, suicidaltanker3, psykose3, mani3, paranoia3, hallucinationer3, eufori3, affektlabilitet3, forvirret tilstand3, aggression3, katatoni3
English: Each dose also contains 105.5 mg of lactose.
Danish: Hver dosis indeholder også 105,5 mg laktose.
English: Cmax: ↓ 19% (↓ 40 to ↑ 10) GS-3310071:
Danish: Cmax: ↓ 19% (↓ 40 til ↑ 10) GS-3310071:
English: If you have both HIV infection and hepatitis B, it is especially important not to stop your Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan treatment without talking to your doctor first.
Danish: Hvis De både har hiv-infektion og hepatitis B, er det særligt vigtigt ikke at stoppe behandlingen med Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan uden at tale med Deres læge først.
English: When efavirenz is co-administered with a calcium channel blocker that is a substrate of the CYP3A4 enzyme, there is a potential for reduction in the plasma concentrations of the calcium channel blocker.
Danish: Når efavirenz administreres samtidigt med en calciumblokker, som er et substrat for CYP3A4-enzymet, er reduktion af calciumblokkerens plasmakoncentrationer mulig.
English: Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan should be taken on an empty stomach (commonly defined as 1 hour before or 2 hours after a meal) preferably at bedtime.
Danish: Efavirenz/Emtricitabine/Tenofovir disoproxil Mylan bør tages på tom mave (sædvanligvis defineret som 1 time før eller 2 timer efter et måltid), helst ved sengetid.