FrancophonIA/ELRC3.0 huggingface dataset:
English: Among 898 hypertensive patients who received various doses of irbesartan/hydrochlorothiazide (range: 37.5 mg/6.25 mg to 300 mg/25 mg) in placebo-controlled trials, 29.5% of the patients experienced adverse reactions.
Slovenian: Med 898 bolniki s hipertenzijo, ki so v s placebom nadzorovanih študijah prejemali različne odmerke kombinacije irbesartan/hidroklortiazid (razpon: 37,5 mg/6,25 mg do 300 mg/25 mg), je 29,5 %
English: Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Slovenian: Preobčutljivostne reakcije na hidroklorotiazid se lahko pojavijo tako pri bolnikih, ki imajo v anamnezi podatek o alergiji ali bronhialni astmi, kot pri tistih, ki ju še niso imeli; pogosteje pa se pojavijo pri tistih, ki so alergijo ali bronhialno astmo že imeli.
English: Irbesartan/Hydrochlorothiazide Teva can be taken once daily, with or without food.
Slovenian: Odmerjanje Zdravilo Irbesartan/hidroklorotiazid Teva se lahko jemlje enkrat na dan skupaj s hrano ali brez nje.
English: Anaphylactic reactions, toxic epidermal necrolysis, necrotizing angitis (vasculitis, cutaneous vasculitis), cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, photosensitivity reactions, rash, urticaria
Slovenian: Bolezni kože in podkožja neznana anafilaktične reakcije, toksična epidermalna nekroliza nekrotizirajoči angiitis (vaskulitis, vnetje kožnih žil ali mezgovnic), reakcije, podobne kožnemu eritematoznemu lupusu, reaktivacija kožnega eritematoznega lupusa, fotosenzitivne reakcije,
English: The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium.
Slovenian: Zaradi diuretskega delovanja hidroklorotiazida se zmanjša prostornina plazme ter zvečata aktivnost renina in izločanje aldosterona; posledično se zveča izguba kalija in hidrogenkarbonata v seču ter zmanjša serumska koncentracija kalija.
English: If you take more Irbesartan/Hydrochlorothiazide Teva than you should
Slovenian: Če ste vzeli večji odmerek zdravila Irbesartan/hidroklorotiazid Teva, kot bi smeli
English: Detailed information on this medicine is available on the European Medicines Agency (EMA) web site: http://www.ema.europa.eu/
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila (EMA)
English: Teva Pharmaceuticals CR, s.r.o.
Slovenian: Česká republika Teva Pharmaceuticals CR, s.r.o.
English: Studies in animals indicate that the radiolabelled irbesartan is detected in rat and rabbit foetuses.
Slovenian: V študijah pri živalih so v zarodkih podgan in kunčjih samic odkrili z radioaktivnim izotopom označen irbesartan.
English: When angiotensin II antagonists are administered simultaneously with non-steroidal anti-inflammatory drugs (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Slovenian: Pri sočasnem zdravljenju z antagonisti angiotenzina II in nesteroidnimi protivnetnimi zdravili (NSAID) (npr. selektivnimi COX-2 zaviralci, acetilsalicilno kislino (> 3 g/dan) in neselektivnimi
English: Irbesartan/Hydrochlorothiazide Teva is used to treat high blood pressure, when treatment with irbesartan or hydrochlorothiazide alone did not provide adequate control of your blood pressure.
Slovenian: Zdravilo Irbesartan/hidroklorotiazid Teva uporabljamo za zdravljenje zvišanega krvnega tlaka, če pri zdravljenju samo z irbesartanom ali samo s hidroklorotiazidom krvni tlak ni bil zadostno nadzorovan.
English: Irbesartan/Hydrochlorothiazide Teva should not be used in patients with severe renal impairment (creatinine clearance < 30 ml/min) (see section 4.3).
Slovenian: Zdravilo Irbesartan/hidroklorotiazid Teva se pri bolnikih s hudo ledvično okvaro (očistek kreatinina < 30 ml/min) ne sme uporabljati (glejte poglavje 4.3).
English: Irbesartan and hydrochlorothiazide (at doses up to 300 mg irbesartan/25 mg hydrochlorothiazide) have been safely administered with other antihypertensive agents including calcium channel blockers and beta-adrenergic blockers.
Slovenian: Uporaba irbesartana in hidroklorotiazida, pri odmerkih do 300 mg irbesartana/25 mg hidroklorotazida, je pri bolnikih, ki dobivajo še druge antihipertenzive, tudi blokatorje kalcijevih kanalčkov in adrenergičnih receptorjev beta, varna.
English: No dosage adjustment is necessary in patients with renal impairment whose renal creatinine clearance is ≥ 30 ml/min (see sections 4.3 and 4.4).
Slovenian: Pri bolnikih z ledvično okvaro, pri katerih je ledvični očistek kreatinina ≥ 30 ml/min prilagoditev odmerka ni potrebna (glejte poglavji 4.3 in 4.4).
English: Not known
Slovenian: neznana
English: What Irbesartan/Hydrochlorothiazide Teva is and what it is used for
Slovenian: Kaj je zdravilo Irbesartan/hidroklorotiazid Teva in za kaj ga uporabljamo
English: In patients with renal impairment or those undergoing haemodialysis, the pharmacokinetic parameters of irbesartan are not significantly altered.
Slovenian: Pri bolnikih z ledvično okvaro in pri tistih na hemodializi farmakokinetični parametri irbesartana niso bistveno spremenjeni.
English: In patients with mild to moderate cirrhosis, the pharmacokinetic parameters of irbesartan are not significantly altered.
Slovenian: Pri bolnikih z blago do zmerno cirozo farmakokinetični parametri irbesartana niso bistveno spremenjeni.
English: TEVA UK Ltd Brampton Road Hampden Park Eastbourne, East Sussex BN22 9AG UK
Slovenian: Eastbourne, East Sussex BN22 9AG
English: Dose titration with the individual components (i.e. irbesartan and hydrochlorothiazide) may be recommended.
Slovenian: Priporočeno je individualno prilagajanje odmerka posameznih učinkovin (irbesartana in hidroklorotiazida).
English: Depression, sleep disturbances
Slovenian: Psihiatrične motnje neznana depresija, motnje spanja
English: Irbesartan/Hydrochlorothiazide Teva is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Slovenian: Zdravila Irbesartan/hidroklorotiazid Teva ne smete jemati, če ste noseči dlje kot 3 mesece, saj lahko zdravilo v tem obdobju resno škoduje vašemu otroku (glejte poglavje o nosečnosti).
English: België/Belgique/Belgien
Slovenian: België/Belgique/Belgien Teva Pharma Belgium N.V./S.A./AG
English: However, occasionally dizziness or weariness may occur during treatment of high blood pressure.
Slovenian: Med zdravljenjem zvišanega krvnega tlaka se lahko občasno pojavi omotica ali utrujenost.
English: Another study showed a possible association between lip cancer (SCC) and exposure to HCTZ: 633 cases of lip-cancer were matched with 63,067 population controls, using a risk-set sampling strategy.
Slovenian: S pomočjo strategije vzorčenja iz tveganih populacij so primerjali 633 primerov raka ustnice s kontrolno populacijo 63.067 bolnikov.
English: The hyperglycaemic effect of beta-blockers and diazoxide may be enhanced by thiazides.
Slovenian: Tiazidni diuretiki lahko zvečajo hiperglikemični učinek blokatorjev beta in diazoksida.
English: However, there was no difference in the half-life and accumulation of irbesartan.
Slovenian: Razlik pri razpolovnem času in kopičenju ni.
English: Animal studies with irbesartan showed transient toxic effects (increased renal pelvic cavitation, hydroureter or subcutaneous oedema) in rat foetuses, which were resolved after birth.
Slovenian: V študijah na živalih so ugotovili pojav prehodnih toksičnih učinkov (zvečano votlino ledvičnega meha, hidroureter ali podkožni edem) pri plodovih podgan, ki pa so po rojstvu izginili.
English: Irbesartan is metabolised by the liver via glucuronide conjugation and oxidation.
Slovenian: Irbesartan se presnavlja v jetrih s konjugacijo z glukuronsko kislino in z oksidacijo.
English: Your doctor will normally advise you to stop taking Irbesartan/Hydrochlorothiazide Teva before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Irbesartan/Hydrochlorothiazide Teva.
Slovenian: Zdravnik vam bo pravilom svetoval, da zdravljenje z zdravilom Irbesartan/hidroklorotiazid Teva prekinete še preden zanosite ali takoj, ko se izkaže, da ste zanosili in vam predpisal zdravljenje z drugim zdravilom.
English: While hydrochlorothiazide is a sulfonamide, only isolated cases of acute angle-closure glaucoma have been reported so far with hydrochlorothiazide.
Slovenian: Hidroklorotiazid je sicer sulfonamid, vendar pa so do sedaj med njegovo uporabo poročali le o posameznih primerih akutnega glavkoma z zaprtim zakotjem.
English: However, in patients with mild to moderate renal impairment (creatinine clearance ≥ 30 ml/min but < 60 ml/min) this fixed dose combination should be administered with caution.
Slovenian: Bolnikom z ledvično okvaro, pri katerih je ledvični očistek ≥ 30 ml/min odmerka zdravila ni treba prilagajati, kljub temu pa je treba tistim z blago ali zmerno ledvično okvaro (očistek kreatinina ≥ 30 ml/min, toda < 60 ml/min) dajati kombinirano zdravilo zelo previdno.
English: White opaque PVC-PVdC - Aluminium blisters or Aluminium - Aluminium blisters.
Slovenian: Beli prozorni PVC-PVdC - aluminijevi pretisni omoti ali aluminij - aluminijevi pretisni omoti.
English: Film-coated tablet.
Slovenian: FARMACEVTSKA OBLIKA Filmsko obložene tablete.
English: Irbesartan/hydrochlorothiazide
Slovenian: Irbesartan/hidroklorotiazid
English: Lithium The combination of lithium and Irbesartan/Hydrochlorothiazide Teva is not recommended (see section 4.5).
Slovenian: Litij Kombinacija litija in zdravila Irbesartan/hidroklorotiazid Teva ni priporočena (glejte poglavje 4.5).
English: Twelve percent (12 %) of patients were diabetic, 34 % were hyperlipidemic and the most frequent cardiovascular condition was stable angina pectoris in 3.5 % of the participants.
Slovenian: Najpogostejša bolezen srca je bila stabilna angina pektoris, ki jo je imelo 3,5 % vključenih bolnikov.
English: These findings appear to have no relevance to the use of therapeutic doses of irbesartan/hydrochlorothiazide in humans.
Slovenian: Ugotovitve pa ne veljajo za terapevtske odmerke irbesartana/hidroklorotiazida pri ljudeh.
English: Prior treatment with high dose diuretics may result in volume depletion and a risk of hypotension when initiating therapy with irbesartan with or without thiazide diuretics unless the volume depletion is corrected first (see section 4.4).
Slovenian: Na začetku zdravljenja z irbesartanom in tiazidnimi diuretiki ali brez njih se lahko zaradi predhodnega zdravljenja z velikimi odmerki diuretikov in posledično zmanjšanega intravaskularnega volumna zveča nevarnost pojava hipotenzije, če predhodno nismo popravili intravaskularnega volumna (glejte poglavje 4.4).
English: No significant effects on the number of corpora lutea, implants, or live foetuses were observed.
Slovenian: Pomembnih učinkov na število rumenih telesc, nidacijo ali preživetje zarodkov niso opazili.
English: TEVA UK Ltd Brampton Road Hampden Park Eastbourne East Sussex BN22 9AG United Kingdom
Slovenian: Eastbourne East Sussex BN22 9AG
English: Medicinal products affecting potassium
Slovenian: Zdravila, ki vplivajo na kalij
English: The other side of the tablet debossed with the number "7238".
Slovenian: Na drugi strani tablete je vtisnjena številka "7238".
English: How to store Irbesartan/Hydrochlorothiazide Teva Contents of the pack and other information
Slovenian: Shranjevanje zdravila Irbesartan/hidroklorotiazid Teva Vsebina pakiranja in dodatne informacije
English: Common side effects (may affect up to 1 in 10 people): nausea/vomiting abnormal urination fatigue dizziness (including when getting up from a lying or sitting position) blood tests may show raised levels of an enzyme that measures the muscle and heart function (creatine kinase) or raised levels of substances that measure kidney function (blood urea nitrogen, creatinine).
Slovenian: siljenje na bruhanje/bruhanje nenormalno uriniranje utrujenost omotica (tudi pri vstajanju iz ležečega ali sedečega položaja)krvne preiskave lahko pokažejo zvišanje vrednosti encima, ki kaže na delovanje mišic in srca (encim kreatin-kinaza), ali zvišanje vrednosti snovi, ki so merilo delovanja ledvic (dušik sečnine v krvi, kreatinin).
English: Irbesartan/Hydrochlorothiazide Teva is a combination of two active substances, irbesartan and hydrochlorothiazide.
Slovenian: Irbesartan/hidroklorotiazid Teva je kombinacija dveh učinkovin, irbesartana in hidroklorotiazida.
English: The active ingredients are irbesartan and hydrochlorothiazide.
Slovenian: Učinkovini sta irbesartan in hidroklorotiazid.
English: A switch to a suitable alternative treatment should be carried out in advance of a planned pregnancy.
Slovenian: Že pred načrtovano nosečnostjo je treba izbrati drugo primerno zdravilo.
English: For Irbesartan/Hydrochlorothiazide Teva packaged in aluminium - aluminium blisters: This medicinal product does not require any special storage conditions.
Slovenian: Za zdravilo Irbesartan/hidroklorotiazid Teva v aluminij - aluminijevih pretisnih omotih: : Za shranjevanje zdravila niso potrebna posebnia navodila.
English: For Irbesartan/Hydrochlorothiazide Teva packaged in white opaque PVC-PVdC - aluminium blisters: Do not store above 30°C.
Slovenian: Za zdravilo Irbesartan/hidroklorotiazid Teva v belih neprozornih PVC-PVdC - aluminijevih pretisnih omotih: Shranjujte pri temperaturi do 30°C.
English: Irbesartan/Hydrochlorothiazide Teva is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Slovenian: Irbesartan/hidroklorotiazid Teva ne smete jemati, če ste noseči dlje kot 3 mesece, saj lahko zdravilo po tretjem mesecu nosečnosti resno škoduje vašemu otroku.
English: Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloremia, hyponatraemia) and dehydration resulting from excessive diuresis.
Slovenian: hipokloremija, hiponatriemija) in dehidracija, ki sta posledica čezmerne diureze.
English: Latent diabetes mellitus may become manifest during thiazide therapy.
Slovenian: Med zdravljenjem s tiazidnimi diuretiki se lahko latentni diabetes mellitus spremeni v manifestnega.
English: The following changes, observed in rats and macaques receiving the irbesartan/hydrochlorothiazide combination at 10/10 and 90/90 mg/kg/day, were also seen with one of the two medicinal products alone and/or were secondary to decreases in blood pressure (no significant toxicologic interactions were observed):
Slovenian: Pri podganah in opicah, ki so prejemale kombinacijo 10 mg irbesartana in 10 mg hidroklorotiazida na kg/dan ter 90 mg irbesartana in 90 mg hidroklorotiazida na kg/dan, so se po znižanju krvnega tlaka (pri čemer niso opazili pomembnih toksikoloških interakcij) zaradi uporabe ene učinkovine ali kombiniranega dajanja pojavile naslednje spremembe:
English: Thiazide therapy may impair glucose tolerance.
Slovenian: Tiazidni diuretiki lahko zmanjšajo toleranco za glukozo.
English: White opaque PVC-PVdC - Aluminium blisters: Do not store above 30°C.
Slovenian: Beli neprozorni PVC-PVdC - aluminijevi pretisni omoti: Shranjujte pri temperaturi do 30°C.
English: You should also tell your doctor:
Slovenian: Posvetujte se tudi,
English: Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter.
Slovenian: Bolniki morajo uživati primerno količino tekočine in po uvedbi sočasne uporabe je priporočljivo redno spremljanje delovanja ledvic.
English: Severe hepatic impairment, biliary cirrhosis and cholestasis The concomitant use of Irbesartan/Hydrochlorothiazide Teva with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1).
Slovenian: • sočasna uporaba zdravila Irbesartan/hidroklorotiazid Teva in zdravil, ki vsebujejo aliskiren, je kontraindicirana pri bolnikih s sladkorno boleznijo ali z okvaro ledvic (hitrost glomerularne filtracije < 60 ml/min/1,73 m2) (glejte poglavji 4.5 in 5.1).
English: Irbesartan/Hydrochlorothiazide Teva is not recommended for use in children and adolescents because the safety and efficacy have not been established.
Slovenian: Varnost in učinkovitost zdravila Irbesartan/hidroklorotiazid Teva nista bili dokazani, zato uporaba pri otrocih in mladostnikih ni priporočljiva.
English: Uncommon side effects (may affect up to 1 in 100 people): diarrhoea low blood pressure fainting heart rate increased flushing swelling sexual dysfunction (problems with sexual performance) blood tests may show lowered levels of potassium and sodium in your blood.
Slovenian: driska nizek krvni tlak omedlevica hiter srčni utrip zardevanje otekline spolne motnje (težave pri spolnih odnosih)krvne preiskave lahko pokažejo znižane vrednosti kalija in natrija v krvi.
English: The use of AIIRAs is not recommended during the first trimester of pregnancy (see section 4.4).
Slovenian: Uporaba antagonistov angiotenzina II v prvem trimesečju nosečnosti ni priporočljiva (glejte poglavje 4.4).
English: If any of these side effects causes you problems, talk to your doctor.
Slovenian: Če imate težave zaradi katerega od navedenih neželenih učinkov, se posvetujte z zdravnikom.
English: Less than 2 % of the dose is excreted in the urine as unchanged irbesartan.
Slovenian: V nespremenjeni obliki se s sečem izloči manj kot 2 % odmerka.
English: The types and incidences of adverse events reported for patients treated with the combination were similar to the adverse event profile for patients on monotherapy.
Slovenian: Pri bolnikih, ki so se zdravili s kombinacijo, so poročali o enaki vrsti in pogostnosti neželenih učinkov kot pri bolnikih, ki so se zdravili samo z eno zdravilno učinkovino.
English: There was no evidence of mutagenicity or clastogenicity with the irbesartan/hydrochlorothiazide combination.
Slovenian: Dokazov o mutagenem in klastogenem delovanju kombinacije irbesartan/hidroklorotiazid ni.
English: Should exposure to AIIRAs have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Slovenian: V primeru izpostavljenosti antagonistom angiotenzina II od drugega trimesečja nosečnosti dalje se priporoča ultrazvočni pregled lobanje in delovanja ledvic.
English: Loss of appetite; stomach irritation; stomach cramps; constipation; jaundice seen as yellowing of the skin and/or whites of the eyes; inflammation of the pancreas characterised by severe upper stomach pain, often with nausea and vomiting; sleep disorders; depression; blurred vision; lack of white blood cells, which can result in frequent infections, fever; decrease in the number of platelets (a blood cell essential for the clotting of the blood), decreased number of red blood cells (anaemia) characterised by tiredness, headaches, being short of breath when exercising, dizziness and looking pale; kidney disease; lung problems including pneumonia or build-up of fluid in the lungs; increased sensitivity of the skin to the sun; inflammation of blood vessels; a skin disease characterized by the peeling of the skin all over the body; cutaneous lupus erythematosus, which is identified by a rash that may appear on the face, neck, and scalp; allergic reactions; weakness and muscle spasm; altered heart rate; reduced blood pressure after a change in body position; swelling of the salivary glands; high sugar levels in the blood; sugar in the urine; increases in some kinds of blood fat; high uric acid levels in the blood, which may cause gout.
Slovenian: Neželeni učinki, ki so povezani z jemanjem hidroklorotiazida samega: Izguba apetita, draženje želodca, krči v želodcu, zaprtost, zlatenica (rumeno obarvanje kože in/ali očesnih beločnic), vnetje trebušne slinavke, za katerega je značilna huda bolečina v zgornjem predelu trebuha, ki jo pogosto spremlja slabost in bruhanja, motnje spanja, depresija, zameglejn vid, zmanjšanje števila belih krvnih celic, ki ima za posledico lahko pogostejše okužbe in zvišano telesno temperaturo, zmanšanje števila trombocitov (krvnih celic, pomembnih za strjevanje krvi), zmanjšanje števila krvnih celic (anemija) za katero je značilna utrujenost, glavobol, zasoplost pri tlesni aktivnosti, omotica in bledica, bolezen ledvic, bolezen pljuč, vključno s pljučnico in kopičenjem tekočine v pljučih, večja občutljivost kože za sončno svetlobo, vnetje krvnih žil, kožna bolezen za katero je značilno luščenje kože po celem telesu, kožni eritematozni lupus, ki se kaže z izpuščajem po obrazu, vratu in lasisšču, alergijske reakcije, oslabelost in krči mišic, spremembe srčnega utripa, znižanje krvnega tlaka po spremembi položaja telesa, otekanje žlez slinavk, zvišanje vrednosti sladkorja v krvi, sladkor v urinu, zvišanje vrednosti nekaterih maščob v krvi, zvišanje vrednosti sečne kisline v krvi, kar lahko povzroči protin.
English: Dual blockade of the renin-angiotensin-aldosterone system (RAAS) There is evidence that the concomitant use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure).
Slovenian: Obstajajo dokazi, da sočasna uporaba zaviralcev ACE, blokatorjev receptorjev angiotenzina II ali aliskirena poveča tveganje za hipotenzijo, hiperkaliemijo in zmanjšano delovanje ledvic (vključno z akutno odpovedjo ledvic).
English: Furthermore, renal clearance of lithium is reduced by thiazides so the risk of lithium toxicity could be increased with irbesartan and hydrochlorothiazide combinations.
Slovenian: Tiazidi zmanjšujejo ledvični očistek litija, zato se med zdravljenjem s kombinacijo irbesartana in hidroklorotiazida poveča nevarnost zastrupitve z litijem.
English: if you experience an increased sensitivity of the skin to the sun with symptoms of sunburn (such as redness, itching, swelling, blistering) occurring more quickly than normal if you are going to have an operation (surgery) or be given anaesthetics if you have changes in your vision or pain in one or both of your eyes while taking Irbesartan/Hydrochlorothiazide Teva.
Slovenian: srbenje, otekline, pojav mehurjev) pojavijo hitreje kot normalno če imate predvideno operacijo (kirurški poseg) ali boste prejeli anestetik če se med jemanjem zdravila Irbesartan/hidroklorotiazid Teva pojavijo spremembe vida ali bolečina v enem ali obeh očesih.
English: Side effects reported in clinical studies for patients treated with the combination of irbesartan and hydrochlorothiazide were:
Slovenian: Med kliničnimi študijami so pri bolnikih, ki so se zdravili s kombinacijo irbesartana in hidroklorotiazida, poročali o naslednjih neželenih učinkih:
English: Irbesartan/Hydrochlorothiazide Teva is a combination of an angiotensin-II receptor antagonist, irbesartan, and a thiazide diuretic, hydrochlorothiazide.
Slovenian: Mehanizem delovanja Zdravilo Irbesartan/hidroklorotiazid Teva je kombinacija irbesartana, antagonista angiotenzina II, in tiazidnega diuretika hidroklorotiazida.
English: Hydrochlorothiazide is a thiazide diuretic.
Slovenian: Hidroklorotiazid je tiazidni diuretik.
English: 6 months toxicity study at irbesartan 90 mg/kg/day, hydrochlorothiazide 90 mg/kg/day, and irbesartan/hydrochlorothiazide 10/10 mg/kg/day.
Slovenian: • pri nekaj podganah, ki so v študiji toksičnosti 6 mesecev dobivale po 90 mg irbesartana na kg/dan in 90 mg hidroklorotiazida na kg/dan ter kombinacijo irbesartana in hidroklorotiazida
English: The hydrochlorothiazide contained in this medicine could produce a positive result in an anti-doping test.
Slovenian: Zaradi hidroklorotiazida, ki ga zdravilo vsebuje, je lahko test za ugotavljanje jemanja nedovoljenih substanc (antidopinški test) pozitiven.
English: The carcinogenic potential of irbesartan and hydrochlorothiazide in combination has not been evaluated in animal studies.
Slovenian: Kancerogenega delovanja te kombinacije v študijah na živalih niso ugotavljali.