FrancophonIA/ELRC3.0 huggingface dataset:
English: adjusted for body surface area resulted in Cmax and AUCτ values which were approximately twofold those attained after 100 mg t.i.d.
Croatian: Doziranje u djece od 200 mg triput dnevno prilagođeno veličini površine tijela dalo je vrijednosti Cmax i AUCτ koje su približno dvostruke od onih dobivenih nakon 100 mg triput dnevno u bolesnika s Gaucherovom bolesti tipa 1, što je sukladno farmakokinetici miglustata linearno ovisnoj o dozi.
English: Muscle spasms, muscle weakness General disorders and administration site reactions Common
Croatian: Mišićni spazmi, slabost u mišićima
English: DATE OF REVISION OF THE TEXT
Croatian: DATUM PRVOG ODOBRENJA/DATUM OBNOVE ODOBRENJA
English: If you get any side effects, talk to your doctor or pharmacist.
Croatian: Ako primijetite bilo koju nuspojavu, potrebno je obavijesti liječnika ili ljekarnika.
English: Dosage
Croatian: Dojenje
English: for an average duration of 2.1 years.
Croatian: 6.3 Rok valjanosti
English: Subcutaneous or intravenus use
Croatian: Subcutaneous, Intramuscular or Intravenous use
English: Dogs and cats
Croatian: Cattle, pigs and horses
English: Bottle (Glass with measuring syringe (LDPE)
Croatian: Polietilena visoke gustoće bočicu + jednom graduiranom brizgalice
English: Target species
Croatian: Meloxidyl
English: 1 ml (180 µg/ml) 4 vials
Croatian: 1 ml (180 µg/ml) 4 bočice
English: 1 ml (180 µg/ml) 1 vial
Croatian: 1 ml (180 µg/ml) 1 bočica
English: Strength Pharmaceutical Form
Croatian: Otopina za injekciju
English: This will prevent infections.
Croatian: To će spriječiti infekcije.
English: These changes may be permanent.
Croatian: Ove promjene mogu biti trajne.
English: Tilt your head back and look at the ceiling.
Croatian: Zabacite glavu unazad i gledajte prema stropu.
English: Put your next dose in at the usual time.
Croatian: Primijenite sljedeću dozu u uobičajeno vrijeme.
English: Risk Management Plan (RMP)
Croatian: • Plan upravljanja rizikom (RMP)
English: You should not drive or use machines until your sight is clear again.
Croatian: Ne biste smjeli upravljati vozilima ili strojevima dok ponovno jasno ne vidite.
English: The duration of effect is maintained for at least 24 hours.
Croatian: Učinak traje najmanje 24 sata.
English: The following pack sizes are available:
Croatian: Dostupne su sljedeće veličine pakiranja:
English: Other medicines and LUMIGAN
Croatian: Drugi lijekovi i LUMIGAN
English: The frequency of these symptoms is not known.
Croatian: Učestalost ovih simptoma nije poznata.
English: No interaction studies have been performed.
Croatian: Nisu provedena ispitivanja interakcija.
English: If overdose occurs, treatment should be symptomatic and supportive.
Croatian: Ako dođe do predoziranja, liječenje treba biti simptomatsko i potporno.
English: • An increase in blood-test results that show how your liver is working
Croatian: • Povišeni rezultati krvnih pretraga koje pokazuju kako radi Vaša jetra
English: The change may be more noticeable if you are only treating one eye.
Croatian: Promjena bi mogla biti uočljivija ako liječite samo jedno oko.
English: It belongs to a group of medicines called prostamides.
Croatian: Pripada skupini lijekova koju nazivamo prostamidima.
English: For single use only, one container is sufficient to treat both eyes.
Croatian: Samo za jednokratnu uporabu; jedan spremnik dovoljan je za oba oka.
English: • Increased blood pressure
Croatian: • Povišeni krvni tlak
English: For single use only
Croatian: Samo za jednokratnu uporabu
English: Other Information
Croatian: Ostale informacije
English: To help you remember, write down the date you opened it in the space on the box.
Croatian: Kako biste lakše zapamtili, zabilježite datum kada ste je otvorili u za to predviđen prostor na kutiji.
English: • Small breaks in the surface of the eye, with or without inflammation
Croatian: • Male pukotine na površini oka, sa ili bez upale
English: This medicine may be used on its own or with other drops called beta-blockers which also reduce pressure.
Croatian: Ovaj lijek možete koristiti sam ili uz druge kapi koje se zovu beta-blokatori i koje također smanjuju tlak.
English: Some of these changes may be permanent, and may lead to differences in appearance between the eyes when only one eye is treated.
Croatian: Neke od tih promjena mogu biti trajne i mogu dovesti do različitog izgleda očiju ako se liječi samo jedno oko.
English: Do not use more than once a day as the effectiveness of treatment may be reduced.
Croatian: Nemojte koristiti češće od jedanput dnevno jer bi učinkovitost liječenja mogla biti smanjena.
English: In human blood, bimatoprost resides mainly in the plasma.
Croatian: U ljudskoj krvi, bimatoprost se većinom nalazi u plazmi.
English: Reduction of the intraocular pressure starts approximately 4 hours after the first administration and maximum effect is reached within approximately 8 to 12 hours.
Croatian: Sniženje intraokularnog tlaka započinje otprilike 4 sata nakon prve primjene, a maksimalan učinak se postiže u roku od otprilike 8 do 12 sati.
English: Animal studies have shown reproductive toxicity at high maternotoxic doses (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su reproduktivnu toksičnost pri visokim maternotoksičnim dozama (vidjeti dio 5.3).
English: Do not store above 25°C.
Croatian: POSEBNE MJERE ČUVANJA Ne čuvati na temperaturi iznad 25°C.
English: LUMIGAN should not be used during pregnancy unless clearly necessary.
Croatian: LUMIGAN se ne bi trebao koristiti tijekom trudnoće osim ako je to izričito neophodno.
English: There was no accumulation of bimatoprost in the blood over time and the safety profile was similar in elderly and young patients.
Croatian: Nije došlo do akumulacije bimatoprosta u krvi tijekom vremena, a sigurnosni profil bio je sličan kod starijih i mlađih pacijenata.
English: This is enough for 4 weeks' usage.
Croatian: To je dovoljno za 4-tjednu primjenu.
English: Your eye contains a clear, watery liquid that feeds the inside of the eye.
Croatian: Vaše oko sadrži prozirnu, vodenastu tekućinu koja hrani unutrašnjost oka.
English: Increased iris pigmentation is likely to be permanent.
Croatian: Pojačana pigmentacija šarenice vjerojatno će biti trajna.
English: For any information about this medicine, please contact the local representative of the marketing authorisation holder.
Croatian: Za sve informacije o ovom lijeku obratite se lokalnom predstavniku nositelja odobrenja za stavljanje lijeka u promet:
English: • Sensitivity to light
Croatian: • Osjetljivost na svjetlost
English: The plasma protein binding of bimatoprost is approximately 88 %.
Croatian: Vezivanje bimatoprosta na proteine plazme iznosi otprilike 88%.
English: • An allergic reaction in the eye
Croatian: • Alergijska reakcija u oku
English: If a drop misses your eye, try again.
Croatian: Ako kap promaši oko, ponovite postupak.
English: LUMIGAN has negligible influence on the ability to drive and use machines.
Croatian: LUMIGAN zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Bimatoprost selectively mimics the effects of newly discovered biosynthesised substances called prostamides.
Croatian: Bimatoprost selektivno imitira učinke novootkrivenih biosintetiziranih tvari koje se nazivaju prostamidi.
English: After ocular administration in adults, the systemic exposure of bimatoprost is very low with no accumulation over time.
Croatian: Nakon primjene u oko odraslih osoba, sistemska izloženost bimatoprostu je vrlo niska bez akumulacije tijekom vremena.
English: It is a synthetic prostamide, structurally related to prostaglandin F2 (PGF2), that does not act through any known prostaglandin receptors.
Croatian: Radi se o sintetskom prostamidu, strukturno srodnom prostaglandinu F2 (PGF2) koji ne djeluje preko poznatih prostaglandinskih receptora.
English: If the high pressure is not reduced, it could lead to a disease called glaucoma and eventually damage your sight.
Croatian: Ako se visoki tlak ne smanji, to može dovesti do nastanka bolesti koju nazivamo glaukom i eventualno do oštećenja vida.
English: In addition, monitoring is required with prolonged use in such patients.
Croatian: Osim toga, kod duže primjene potrebno je pratiti takve bolesnike.
English: You must throw away the bottle at the latest four weeks after you first opened it, even if there are still some drops left.
Croatian: Bočicu morate baciti najkasnije četiri tjedna nakon što ste je prvi put otvorili, čak i ako je u njoj ostalo još nekoliko kapi.
English: The requirements for submission of periodic safety update report for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Croatian: Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim sljedećim ažuriranim verzijama objavljenima na europskom internetskom portalu za lijekove.
English: • Worsening of asthma
Croatian: • Pogoršanje astme
English: This medicine is for single use only and does not contain preservatives.
Croatian: Ovaj lijek namijenjen je samo za jednokratnu primjenu i ne sadrži konzervanse.
English: This medicine works by increasing the amount of liquid that is drained.
Croatian: Ovaj lijek djeluje tako da povećava količinu tekućine koja istječe.
English: Pharmacotherapeutic group: Ophthalmologicals, prostaglandin analogues, ATC code: S01EE03.
Croatian: Farmakoterapijska skupina: Oftalmici, analozi prostaglandina, ATK oznaka: S01EE03.
English: If you wear contact lenses, take your lenses out before using this medicine.
Croatian: Ako nosite kontaktne leće skinite ih prije primjene lijeka.
English: The prostamide receptor, however, has not yet been structurally identified.
Croatian: Struktura prostamidskog receptora, međutim, još nije identificirana.
English: - The active substance is bimatoprost.
Croatian: - Djelatna tvar je bimatoprost.
English: Neurobehavioural functions of offspring were not affected.
Croatian: Nisu bile zahvaćene neurobihevioralne funkcije potomstva.
English: If you are pregnant or breast-feeding, think you might be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: No functional or microscopic changes related to the periocular effects were observed, and the mechanism of action for the periocular changes is unknown.
Croatian: Nisu primijećene nikakve funkcionalne niti mikroskopske promjene povezane uz periokularne učinke, a sam mehanizam djelovanja kod periokularnih promjena nije poznat.
English: Fertility There are no data on the effects of bimatoprost on human fertility.
Croatian: Plodnost Nema podataka o utjecaju bimatoprosta na plodnost ljudi.
English: Put the cap back on and close the bottle straight after you have used it.
Croatian: Vratite zatvarač i zatvorite bočicu odmah nakon uporabe.
English: Warnings and precautions:
Croatian: Upozorenja i mjere opreza
English: • Worsening of the lung disease called chronic obstructive pulmonary disease (COPD)
Croatian: • Pogoršanje bolesti pluća poznate pod nazivom kronična opstruktivna bolest pluća (KOPB)
English: There are no adequate data from the use of bimatoprost in pregnant women.
Croatian: Ne postoje adekvatni podaci o primjeni bimatoprosta kod trudnica.
English: As with any ocular treatment, if transient blurred vision occurs at instillation, the patient should wait until the vision clears before driving or using machines.
Croatian: Kao i kod svake druge terapije oka, ako se nakon primjene pojavi prolazna zamagljenost vida, bolesnik treba pričekati da se vid popravi prije upravljanja vozilima ili rada sa strojevima.
English: Gently pull down the lower eyelid until there is a small pocket.
Croatian: Pažljivo povucite donju vjeđu dok se ne stvori mali džep.
English: The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytes.
Croatian: Ova promjena pigmentacije nastaje više zbog povećanja sadržaja melanina u melanocitima nego li zbog povećanja broja melanocita.
English: This reduces the pressure inside the eye.
Croatian: To snižava tlak u oku.
English: However, this finding is not clinically relevant as systemic exposure for both elderly and young subjects remained very low from ocular dosing.
Croatian: Međutim, ti rezultati nisu klinički relevantni jer je sistemska izloženost i kod starijih i kod mlađih ispitanika ostala vrlo niska zbog okularne primjene.
English: 4 weeks after first opening.
Croatian: 4 tjedna nakon prvog otvaranja.
English: Skin
Croatian: Koža
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivosti na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: LUMIGAN may get into breast milk so you should not breast-feed while you are taking LUMIGAN.
Croatian: LUMIGAN može dospjeti u mlijeko dojilja stoga ne smijete dojiti dok uzimate LUMIGAN.
English: • Difficulty in seeing clearly
Croatian: • Poteškoće u jasnoći vida
English: 5 pack - Do not store above 25°C 30 pack - No special requirements for storage 90 pack - No special requirements for storage 6.5 Nature and contents of container
Croatian: 6.4 Posebne mjere pri čuvanju lijeka pakiranje od 5 - ne čuvati na temperaturi iznad 25°C pakiranje od 30 - nisu potrebni posebni uvjeti čuvanja pakiranje od 90 - nisu potrebni posebni uvjeti čuvanja 6.5 Vrsta i sadržaj spremnika
English: Characteristics in elderly patients
Croatian: Osobitosti u starijih bolesnika
English: Thus, it is important to apply LUMIGAN as instructed and avoid it running onto the cheek or other skin areas.
Croatian: Stoga je važno LUMIGAN primjenjivati na način kako je objašnjeno kako bi se izbjeglo njegovo curenje po obrazima ili drugim područjima kože.
English: Package Leaflet: Information for the user
Croatian: Uputa o lijeku: Informacije za korisnika
English: LUMIGAN should only be applied to the eye.
Croatian: LUMIGAN treba primijeniti isključivo u oko.
English: The following pack sizes are available: cartons containing 1 or 3 bottles of 3 ml solution.
Croatian: Dostupne su sljedeće veličine pakiranja: kutija s 1 ili 3 bočice s 3 ml otopine.
English: Patients with a disruption of the ocular epithelial surface are at greater risk of developing bacterial keratitis.
Croatian: Bolesnici kod kojih postoji oštećenje epitela oka imaju veći rizik za razvoj bakterijskog keratitisa.
English: There is a potential for hair growth to occur in areas where LUMIGAN solution comes repeatedly in contact with the skin surface.
Croatian: Postoji mogućnost rasta dlaka u područjima u kojima površina kože opetovano dolazi u kontakt s otopinom LUMIGAN.
English: Any unused solution should be discarded immediately after use.
Croatian: Svu neiskorištenu otopinu nakon korištenja treba odmah baciti.
English: The long term effects of increased iris pigmentation are not known.
Croatian: Dugotrajni učinci pojačanja pigmentacije šarenice nisu poznati.
English: Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: • Symptoms of allergic reaction (swelling, redness of the eye and rash of the skin)
Croatian: • Simptomi alergijske reakcije (oticanje, crvenilo očiju i kožni osip)
English: Opened:
Croatian: Otvoreno:
English: To help prevent infections and avoid eye injury, do not let the tip of the bottle touch your eye or anything else.
Croatian: Kako biste spriječili infekcije i izbjegli ozljeđivanje oka, nemojte vrškom bočice doticati oko niti bilo koju drugu površinu.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA
Croatian: JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM PC
English: Let go of the lower lid, and close your eye for 30 seconds.
Croatian: Otpustite donju vjeđu i zatvorite oko u trajanju od 30 sekundi.
English: If more than one topical ophthalmic medicinal product is being used, each one should be administered at least 5 minutes apart.
Croatian: Ako treba koristiti više od jednog topikalnog oftalmološkog lijeka, treba ih primjenjivati u razmacima od najmanje 5 minuta.
English: • Feeling of sickness
Croatian: • Osjećaj mučnine
English: Do not use this medicine: - If you are allergic to bimatoprost or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte primjenjivati ovaj lijek: - ako ste alergični na bimatoprost ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Conjunctival hyperaemia, growth of eyelashes, and eye pruritus were statistically significantly higher with bimatoprost than with latanoprost, however, the discontinuation rates due to adverse events were low with no statistically significant difference.
Croatian: Konjunktivna hiperemija, rast trepavica i svrbež oka bili su statistički značajno viši s bimatoprostom u usporedbi s latanoprostom, međutim, stope prekida zbog nuspojava bile su niske i bez statistički značajne razlike.
English: A decision must be made whether to discontinue breast-feeding or to discontinue from LUMIGAN therapy taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je donijeti odluku hoće li se prekinuti dojenje ili prekinuti liječenje kapima LUMIGAN uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: Co. Mayo,
Croatian: Mayo,
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 07 January 2010
Croatian: Datum prvog odobrenja: 07. siječnja 2010.
English: Benzalkonium chloride, which is commonly used as a preservative in ophthalmic products, has been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy.
Croatian: Za benzalkonijev klorid, koji se u oftalmološkim lijekovima uobičajeno koristi kao konzervans, zabilježeno je da izaziva točkastu keratopatiju i/ili toksičnu ulcerativnu keratopatiju.
English: Bimatoprost then undergoes oxidation, N-deethylation and glucuronidation to form a diverse variety of metabolites.
Croatian: Bimatoprost zatim podliježe oksidaciji, N-deetilaciji i glukuronidaciji uz stvaranje različitih metabolita.
English: Bimatoprost is eliminated primarily by renal excretion, up to 67 % of an intravenous dose administered to healthy adult volunteers was excreted in the urine, 25 % of the dose was excreted via the faeces.
Croatian: Bimatoprost se primarno eliminira izlučivanjem putem bubrega, do 67% intravenske doze primijenjene na zdravim odraslim dobrovoljcima izlučilo se u mokraći, a 25% doze izlučilo se putem stolice.
English: Small amounts of hydrochloric acid or sodium hydroxide may be added to keep the level of acid (pH levels) normal.
Croatian: Mala količina kloridne kiseline ili natrijeva hidroksida može biti dodana za održavanje normalnog stupnja kiselosti (pH vrijednosti).
English: This medicine does not contain a preservative.
Croatian: Ovaj lijek ne sadrži konzervanse.
English: Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye or surrounding structures, to avoid eye injury and contamination of the solution.
Croatian: Bolesnike treba uputiti da izbjegavaju doticanje oka ili okolnih struktura vrškom spremnika za doziranje kako bi se izbjegla ozljeda oka i onečišćenje otopine.
English: These doses resulted in systemic exposures of at least 33- or 97-times higher, respectively, than the intended human exposure.
Croatian: Te su doze rezultirale sistemskom izloženosti barem 33 odnosno 97 puta većom od namjeravane izloženosti kod ljudi.
English: • Irritation, when drop is put in the eye
Croatian: • Nadražaj, kada se kap stavi u oko
English: Animal studies have shown excretion of bimatoprost in breast milk.
Croatian: Ispitivanja na životinjama pokazala su izlučivanje bimatoprosta u mlijeko životinja u laktaciji.
English: • Macular oedema (swelling of the retina at the back of the eye which may lead to worsening vision)
Croatian: • Makularni edem (oticanje mrežnice u pozadini oka, što može dovesti do pogoršanja vida)
English: LUMIGAN has not been studied in patients with heart block more severe than first degree or uncontrolled congestive heart failure.
Croatian: LUMIGAN nije ispitivan kod bolesnika sa srčanim blokom težim od prvog stupnja ili nekontroliranom kongestivnom srčanom insuficijencijom.
English: If you are worried, talk to your doctor or pharmacist.
Croatian: Ako ste zabrinuti, razgovarajte sa svojim liječnikom ili ljekarnikom.
English: The table also includes those adverse reactions which occurred with both formulations but at a different frequency.
Croatian: Tablica uključuje i nuspojave koje su zabilježene s obje formulacije lijeka, ali s različitom učestalošću.
English: On combining the data from phase III monotherapy and adjunctive LUMIGAN 0.3 mg/ml eye drops, solution usage, the most frequently reported treatment-related adverse events were: growth of eyelashes in up to 45% in the first year with the incidence of new reports decreasing to 7% at 2 years and 2% at 3 years, conjunctival hyperaemia (mostly trace to mild and thought to be of a noninflammatory nature) in up to 44% in the first year with the incidence of new reports decreasing to 13% at 2 years and 12% at 3 years and ocular pruritus in up to 14% of patients in the first year with the incidence of new reports decreasing to 3% at 2 years and 0% at 3 years.
Croatian: Kombinirajući podatke dobivene ispitivanjem faze III monoterapije i kombinirane terapije s LUMIGAN 0,3 mg/ml kapima za oko, najčešće prijavljene nuspojave povezane uz liječenje bile su: rast trepavica kod do 45% bolesnika u prvoj godini, s opadanjem incidencije novih prijava na 7% u 2. godini i na 2% u 3. godini, hiperemija konjunktive (uglavnom u tragovima ili u blagom obliku te neupalne prirode) kod do 44% bolesnika u prvoj godini, s opadanjem incidencije na 13% u 2. godini i na 12% u 3. godini te svrbež oka kod do 14% bolesnika u prvoj godini, s opadanjem incidencije novih prijava na 3% u 2. godini i 0% u 3. godini.
English: The increased iris pigmentation appears to be caused by increased stimulation of melanin production in melanocytes and not by an increase in melanocyte number.
Croatian: Povećana pigmentacija šarenice vjerojatno je prouzročena pojačanom stimulacijom proizvodnje melanina u melanocitima, a ne povećanjem broja melanocita.
English: • Asthma
Croatian: • Astma
English: If you stop using LUMIGAN the pressure inside your eye may go up, therefore talk to your doctor before stopping this treatment.
Croatian: Ako prestanete primjenjivati LUMIGAN, tlak u oku bi Vam mogao porasti, stoga razgovarajte sa svojim liječnikom prije prekida liječenja.
English: Mean Cmax and AUC 0-24hrs values were similar on days 7 and 14 at approximately 0.08 ng/ml and 0.09 ng•hr/ml respectively, indicating that a steady bimatoprost concentration was reached during the first week of ocular dosing.
Croatian: Srednje vrijednosti Cmax i AUC 0-24h bile su slične 7. i 14. dana i to otprilike 0,08 ng/ml odnosno 0,09 ng•h/ml, što ukazuje da je postignuta stabilna koncentracija bimatoprosta tijekom prvog tjedna okularne primjene.
English: Reduction of elevated intraocular pressure in chronic open-angle glaucoma and ocular hypertension in adults (as monotherapy or as adjunctive therapy to beta-blockers).
Croatian: Snižavanje povišenog intraokularnog tlaka kod odraslih s kroničnim glaukomom otvorenog kuta i okularnom hipertenzijom (kao monoterapija ili kao dodatna terapija uz beta-blokatore).
English: No case of overdose has been reported, and is unlikely to occur after ocular administration.
Croatian: Nije prijavljen nijedan slučaj predoziranja i nije vjerojatno da predoziranje može nastupiti nakon okularne primjene.
English: LUMIGAN is an antiglaucoma preparation.
Croatian: LUMIGAN je pripravak za liječenje glaukoma.
English: System Organ class
Croatian: Klasifikacija organskog sustava