FrancophonIA/ELRC3.0 huggingface dataset:
English: Total oral clearance (CL/F) was 34-62 L/h.
Croatian: Ukupni klirens nakon peroralne primjene (CL/F) iznosio je 34-62 l/sat.
English: Decreases in blood glucose, in some cases clinically symptomatic and requiring hospitalisation due to loss of consciousness, have been reported during sunitinib treatment.
Croatian: Sniženje razine glukoze u krvi, koje je u nekim slučajevima bilo klinički simptomatsko i zahtijevalo hospitalizaciju uslijed gubitka svijesti, prijavljeno je tijekom liječenja sunitinibom.
English: These may be symptoms of heart problems that may include heart failure and heart muscle problems (cardiomyopathy).
Croatian: To mogu biti simptomi srčanih tegoba koje mogu uključivati zatajenje srca i tegobe sa srčanim mišićem (kardiomiopatija).
English: Sunitinib (0.3, 1.0, 3.0 mg/kg/day) was evaluated in a pre-and postnatal development study in pregnant rats.
Croatian: Sunitinib (0,3; 1,0; 3,0 mg/kg na dan) je ispitan u istraživanju prenatalnog i postnatalnog razvoja u gravidnih štakorica.
English: The PK of sunitinib were evaluated in 135 healthy volunteers and 266 patients with solid tumours.
Croatian: FK sunitiniba bila je ispitana u 135 zdravih dobrovoljaca te u 266 bolesnika sa solidnim tumorima.
English: Objective response rate [%, (95% CI)]
Croatian: Stopa objektivnog odgovora [% (95% CI)]
English: • Influenza-like syndrome.
Croatian: • Sindrom nalik gripi.
English: Studies in animals have shown reproductive toxicity including foetal malformations (see section 5.3).
Croatian: Istraživanja na životinjama pokazala su reproduktivnu toksičnost, uključujući i malformacije ploda (vidjeti dio 5.3).
English: Sutent contains the active substance sunitinib, which is a protein kinase inhibitor.
Croatian: Sutent sadrži djelatnu tvar sunitinib, koja je inhibitor protein kinaze.
English: Other side effects with Sutent may include:
Croatian: Ostale nuspojave liječenja lijekom Sutent mogu biti:
English: Weight, performance status
Croatian: Tjelesna težina, funkcionalno stanje
English: The primary objective was to compare PFS in patients receiving sunitinib versus patients receiving placebo.
Croatian: Primarni cilj bio je usporediti PFS u bolesnika koji su dobivali sunitinib naspram bolesnika koji su primali placebo.
English: Increases in the QTc interval to over 500 msec were reported in 0.5%, and changes from baseline in excess of 60 msec were reported in 1.1% of the 450 solid tumour patients; both of these parameters are recognised as potentially significant changes.
Croatian: Produljenje QTc-intervala na više od 500 ms prijavljeno je u 0,5%, a promjene za više od 60 ms u odnosu na početne vrijednosti u 1,1% od ukupno 450 bolesnika sa solidnim tumorima; oba navedena parametra smatraju se potencijalno značajnim promjenama.
English: - If you have or have had damage to the smallest blood vessels known as thrombotic microangiopathy (TMA).
Croatian: - ako imate ili ste imali oštećenje najmanjih krvnih žila poznato kao trombotička mikroangiopatija (TMA).
English: Sunitinib and its primary metabolite are mainly metabolised by the liver.
Croatian: Sunitinib i njegov primarni metabolit uglavnom se metaboliziraju u jetri.
English: • Overproduction of thyroid hormones which increases the amount of energy the body uses at rest.
Croatian: • Pojačano lučenje hormona štitnjače koje povećava količinu energije potrebne tijelu u mirovanju.
English: Overall, 7% of the MRCC population had either clinical or laboratory evidence of treatment-emergent hypothyroidism.
Croatian: Ukupno je 7% bolesnika u populaciji s MRCC-om imalo kliničke ili laboratorijske dokaze hipotireoze izazvane liječenjem.
English: Dysgeusia, ageusia, and taste disturbance.
Croatian: Disgeuzija, ageuzija i poremećaj okusa k
English: The calculated in vitro Ki values for all cytochrome P450 (CYP) isoforms tested (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5, and CYP4A9/11) indicated that sunitinib and its primary active metabolite are unlikely to induce metabolism, to any clinically relevant extent, of other actives substances that may be metabolised by these enzymes.
Croatian: Ki vrijednosti in vitro za sve ispitane P450 CYP izoforme (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5 i CYP4A9/11) pokazao je kako nije vjerojatno da sunitinib i njegov primarni aktivni metabolit u klinički relevantnoj mjeri induciraju metabolizam drugih djelatnih tvari koje se mogu metabolizirati pomoću navedenih enzima.
English: In some cases of suspected EM, patients tolerated the reintroduction of sunitinib therapy at a lower dose after resolution of the reaction; some of these patients also received concomitant treatment with corticosteroids or antihistamines (see section 4.8).
Croatian: U nekim slučajevima za koje postoji sumnja na EM bolesnici su podnijeli ponovno uvođenje terapije sunitinibom u nižim dozama nakon povlačenja reakcije; neki od tih bolesnika su također primali istodobno liječenje kortikosteroidima ili antihistaminicima (vidjeti dio 4.8).
English: • Abnormal changes in the brain that can cause a collection of symptoms including headache, confusion, seizures, and vision loss (reversible posterior leukoencephalopathy syndrome).
Croatian: • Abnormalne promjene u mozgu koje mogu uzrokovati skup simptoma uključujući glavobolju, smetenost, napdaje i gubitak vida (sindrom reverzibilne posteriorne leukoencelopatije).
English: Treatment with Sutent may lead to a higher risk of bleeding or lead to changes in the number of certain cells in the blood which may lead to anaemia or affect the ability of your blood to clot.
Croatian: Liječenje lijekom Sutent može povećati rizik od krvarenja ili izazvati promjene broja određenih krvnih stanica, što može dovesti do anemija ili ometati zgrušavanje krvi.
English: - If you have diabetes.
Croatian: - ako imate šećernu bolest.
English: • Infections.
Croatian: • Infekcije.
English: - Gastrointestinal stromal tumour (GIST), a type of cancer of the stomach and bowel, where imatinib (another anticancer medicine) no longer works or you cannot take imatinib.
Croatian: - gastrointestinalni stromalni tumor (GIST), jednu vrstu raka želuca i crijeva, i to kada imatinib (drugi lijek protiv raka) više ne djeluje ili ga ne smijete uzimati.
English: Monitor liver function tests (alanine transaminase [ALT], aspartate transaminase [AST], bilirubin levels) before initiation of treatment, during each cycle of treatment, and as clinically indicated.
Croatian: Potrebno je kontrolirati jetrenu funkciju (razine alanin transaminaze [ALT], aspartat transaminaze [AST] i bilirubina) prije početka liječenja, tijekom svakog ciklusa liječenja te kada je klinički indicirano.
English: b Efficacy results for the 99 subjects who crossed over from placebo to Sutent after unblinding.
Croatian: b Rezultati djelotvornosti za 99 bolesnika koji su s placeba prešli na Sutent nakon otkrivanja slijepe šifre terapije.
English: Patients with signs or symptoms of muscle toxicity should be managed as per standard medical practice (see section 4.4).
Croatian: Bolesnike sa znakovima ili simptomima mišićne toksičnosti moraju se liječiti u skladu s uobičajenom medicinskom praksom (vidjeti dio 4.4).
English: Effect of Breast Cancer Resistance Protein (BCRP) inhibitors Limited clinical data are available on the interaction between sunitinib and BCRP inhibitors and the possibility of an interaction between sunitinib and other BCRP inhibitors cannot be excluded (see section 5.2).
Croatian: Breast Cancer Resistance Protein, BCRP) Dostupni su ograničeni klinički podaci o interakciji sunitiniba i inhibitora BCRP-a te se mogućnost interakcije sunitiniba i drugih inhibitora BCRP-a ne može isključiti (vidjeti dio 5.2).
English: Data from non clinical (in vitro and in vivo) studies, at doses higher than the recommended human dose, indicated that sunitinib has the potential to inhibit the cardiac action potential repolarisation process (e.g., prolongation of QT interval).
Croatian: Podaci iz nekliničkih istraživanja (in vitro i in vivo) pri dozama većima od preporučene doze za ljude ukazuju na to da sunitinib može inhibirati proces repolarizacije srčanog akcijskog potencijala (npr. produljiti QT-interval).
English: Similarly, body surface area was a significant covariate on the apparent clearance of the active metabolite (the lower the body surface area, the lower the apparent clearance).
Croatian: Slično, površina tijela bila je značajna varijabla za prividni klirens djelatnog metabolita (što je manja površina tijela, to je niži prividni klirens).
English: Physicians are advised to weigh this risk against the potential benefits of sunitinib.
Croatian: Preporučuje se da liječnici odvagnu taj rizik u odnosu na moguću korist liječenja sunitinibom.
English: If signs or symptoms of SJS, TEN, or EM (e.g., progressive skin rash often with blisters or mucosal lesions) are present, sunitinib treatment should be discontinued.
Croatian: Ako su znakovi ili simptomi SJS, TEN ili EM prisutni (npr. progresivni kožni osip često s mjehurima ili oštećenjima sluznice) liječenje sunitinibom treba prekinuti.
English: Sutent is not approved for use in patients with lung cancer.
Croatian: Sutent nije odobren za primjenu u bolesnika s rakom pluća.
English: Severe hypertension (> 200 mmHg systolic or 110 mmHg diastolic) was reported in 4.7% of patients with solid tumours.
Croatian: Teška hipertenzija (sistolički krvni tlak >200 mmHg ili dijastolički krvni tlak 110 mmHg) prijavljena je u 4,7% bolesnika sa solidnim tumorima.
English: Stepwise covariate modelling analyses were performed to evaluate the effect of age and body size (total body weight or body surface area) as well as other covariates on important PK parameters for sunitinib and its active metabolite.
Croatian: Postupne analize modeliranja varijabli provedene su kako bi se procijenio učinak dobi i veličine tijela (ukupna težina tijela ili površina tijela) kao i ostalih varijabli na važne FK parametre za sunitinib i njegov djelatni metabolit.
English: - You may be advised to have a dental check-up before you start treatment with Sutent.
Croatian: - možda će Vam biti preporučeno da prije početka liječenja lijekom Sutent obavite pregled zuba.
English: At approximately twice therapeutic concentrations, sunitinib has been shown to prolong the QTcF interval (Fridericia corrected QT interval).
Croatian: Pri koncentracijama približno dvostruko većima od terapijskih pokazalo se da sunitinib produljuje QTcF-interval (korekcija prema Fridericiji).
English: • Difficulty in falling asleep.
Croatian: • Poteškoća pri usnivanju.
English: Subject did not progress or die [n (%)] Subject observed to have progressed or died [n (%)]
Croatian: Ispitanici u kojih nije došlo do progresije niti smrti [n (%)] Ispitanici u kojih je došlo do progresije ili smrti [n (%)] PFS (tjedni)
English: The most frequent events included cerebrovascular accident, transient ischaemic attack, and cerebral infarction.
Croatian: Najčešći događaji obuhvaćaju cerebrovaskularni incident, tranzitornu ishemijsku ataku i moždani udar.
English: Your doctor will determine the appropriate dose you need to take, as well as if and when you need to stop treatment with Sutent.
Croatian: Vaš će liječnik odrediti odgovarajuću dozu koju trebate uzimati kao i kada trebate prestati uzimati Sutent.
English: • Severe reaction of the skin and/or mucous membranes (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme).
Croatian: • Teška reakcija kože i/ili sluznica (Stevens-Johnsov sindrom, toksična epidermalna nekroliza, multiformni eritem).
English: Sunitinib has not been studied in subjects with severe (Child-Pugh class C) hepatic impairment and therefore its use in patients with severe hepatic impairment cannot be recommended (see section 5.2).
Croatian: Sunitinib nije ispitivan u bolesnika s teškim oštećenjem jetre (Child-Pugh stadij C) te se stoga njegova primjena u bolesnika s teškim oštećenjem jetre ne može preporučiti (vidjeti dio 5.2).
English: How to take Sutent
Croatian: Kako uzimati Sutent
English: Kaplan-Meier plot of PFS in the pNET Phase 3 study
Croatian: Slika 1 Kaplan-Meierova krivulja PFS-a u ispitivanju pNET-a faze III
English: Notify your doctor as soon as possible if you have high blood pressure, headache, or loss of sight.
Croatian: Što prije obavijestite liječnika ako imate povišen krvni tlak, glavobolju ili gubitak vida.
English: Sutent can cause abnormality of your heart rhythm.
Croatian: Sutent može prouzročiti odstupanja od normalnog ritma otkucaja srca.
English: The active substance is sunitinib.
Croatian: Djelatna tvar je sunitinib.
English: This analysis was based on data collected from adults with GIST or solid tumours and from paediatric patients with solid tumours.
Croatian: Ova analiza temeljila se na podacima prikupljenima od odraslih osoba s GIST-om ili solidnim tumorima i od pedijatrijskih bolesnika sa solidnim tumorima.
English: Your doctor may check your blood pressure during treatment with Sutent, and you may be treated with medicines to reduce the blood pressure, if needed.
Croatian: Liječnik Vam tijekom liječenja lijekom Sutent može kontrolirati krvni tlak te, bude li potrebno, možete dobiti lijekove za snižavanje krvnog tlaka.
English: Do not take Sutent:
Croatian: Nemojte uzimati Sutent
English: Some medicines can affect the levels of Sutent in your body.
Croatian: Neki lijekovi mogu utjecati na koncentracije lijeka Sutent u organizmu.
English: Approximately 22.2% of patients with solid tumours, including GIST and MRCC, who received sunitinib in clinical trials experienced pulmonary events.
Croatian: U približno 22,2% bolesnika sa solidnim tumorima, uključujući GIST i MRCC, koji su primali sunitinib u kliničkim ispitivanjima, nastupili su plućni događaji.
English: A total of 255 patients received sunitinib in the open-label treatment phase of the study, including 99 patients who were initially treated with placebo.
Croatian: Ukupno je 255 bolesnika dobivalo sunitinib u otvorenoj fazi ispitivanja, uključujući 99 bolesnika koji su početno dobivali placebo.
English: In the 807 patients who received long-term sunitinib treatment, most treatment-related adverse events (TRAEs) occurred initially in the first 6 months-1 year and then were stable or decreased in frequency over time, with the exception of hypothyroidism, which gradually increased over time, with new cases occurring over the 6 year period.
Croatian: U 807 bolesnika dugoročno liječenih sunitinibom, većina štetnih događaja vezanih uz liječenje (engl. treatment-related adverse events, TRAE) inicijalno se javila unutar prvih 6 mjeseci do godinu dana, nakon čega su bili stabilni ili im se učestalost smanjivala s vremenom, s izuzetkom hipotireoze, čija je učestalost s vremenom rasla, uz nove slučajeve koji su se javljali kroz period od 6 godina.
English: While you are on this medicine "pyoderma gangrenosum" (painful skin ulceration) or “necrotising fasciitis” (rapidly spreading infection of the skin/soft tissue that may be life-threatening) may occur.
Croatian: Dok se liječite ovim lijekom može se razviti "pyoderma gangrenosum" (bolne ulceracije kože) ili "nekrotizirajući fasciitis" (infekcija kože/mekih tkiva koja se brzo širi i može biti opasna po život).
English: • Deficiency of blood supply to the heart muscle, due to obstruction or constriction of the coronary arteries.
Croatian: • Nedostatak opskrbe srčanog mišića krvlju zbog začepljenja ili suženja koronarnih arterija.
English: Tumour haemorrhage may occur suddenly, and in the case of pulmonary tumours, may present as severe and life-threatening haemoptysis or pulmonary haemorrhage.
Croatian: Tumorsko krvarenje može nastupiti iznenada, a u slučaju tumora pluća može se ispoljiti kao teška i po život opasna hemoptiza ili plućno krvarenje.
English: Sunitinib and/or its metabolites are excreted in rat milk.
Croatian: Sunitinib i/ili njegovi metaboliti izlučuju se u mlijeko štakorica.
English: • Problems with wound healing after surgery.
Croatian: • Otežano cijeljenje rana nakon operacije.
English: Median PFS was 2.3 months in the HGG group and 2.7 months in the ependymoma group.
Croatian: Medijan PFS-a iznosio je 2,3 mjeseca u skupini s gliomom visokog gradusa i 2,7 mjeseci u skupini s ependimomom.
English: The overall PFS and OS, observed in the ITT population, as determined by the core radiology laboratory assessment, are summarised in Table 3.
Croatian: Ukupni PFS i OS zabilježeni u populaciji svih uključenih bolesnika (ITT populacija) te utvrđeni središnjom procjenom ključnih radioloških nalaza sažeti su u tablici 3.
English: Hypertension has been reported in association with sunitinib, including severe hypertension (> 200 mmHg systolic or 110 mmHg diastolic).
Croatian: Prijavljena je hipertenzija povezana sa sunitinibom, uključujući tešku hipertenziju (> 200 mmHg sistolički ili 110 mmHg dijastolički krvni tlak).
English: High-density polyethylene (HDPE) bottle with a polypropylene closure containing 30 hard capsules.
Croatian: Bočica od polietilena visoke gustoće (HDPE) s polipropilenskim zatvaračem koja sadrži 30 tvrdih kapsula.
English: Patients who presented with pulmonary embolism within the previous 12 months were excluded from sunitinib clinical studies.
Croatian: Bolesnici koji su u prethodnih 12 mjeseci imali plućnu emboliju nisu bili uključeni u klinička ispitivanja sunitiniba.
English: Because active substances are commonly excreted in human milk and because of the potential for serious adverse reactions in breast-feeding infants, women should not breast-feed while taking Sutent.
Croatian: S obzirom da se lijekovi uobičajeno izlučuju u majčino mlijeko, kao i zbog mogućih ozbiljnih nuspojava u dojenčeta, žene ne smiju dojiti za vrijeme liječenja lijekom Sutent.
English: Discontinue sunitinib in patients with nephrotic syndrome.
Croatian: Treba prekinuti liječenje sunitinibom u bolesnika s nefrotskim sindromom.
English: c The interim PFS numbers have been updated based on a recalculation of the original data.
Croatian: c Interim rezultati PFS-a (preživljenja bez progresije, engl. progression free survival) su ažurirani na temelju ponovnog izračuna izvornih podataka.
English: Your doctor may obtain electrocardiograms to evaluate for these problems during your treatment with Sutent.
Croatian: Liječnik može učiniti elektrokardiogram kako bi procijenio te tegobe dok se liječite lijekom Sutent.
English: Poly(chlorotrifluoroethylene)/PVC transparent perforated unit dose blister with aluminium foil coated with heat seal lacquer containing 28 x 1 hard capsules.
Croatian: Prozirni poli(klorotrifluoroetien)/PVC perforirani blister djeljiv na jedinične doze s aluminijskom folijom obloženom lakom za toplinsko lijepljenje koji sadrži 28 x 1 tvrdu kapsulu.
English: Patients with pre-existing hypothyroidism or hyperthyroidism should be treated as per standard medical practice prior to the start of sunitinib treatment.
Croatian: Bolesnici s već postojećom hipotireozom ili hipertireozom moraju se prije započinjanja terapije sunitinibom liječiti u skladu sa standardnom medicinskom praksom.
English: Sunitinib did not induce structural chromosome aberrations in human peripheral blood lymphocyte cells in vitro.
Croatian: Sunitinib nije potaknuo strukturne kromosomske aberacije u humanim limfocitnim stanicama u perifernoj krvi in vitro.
English: By Day 14, combined plasma concentrations of sunitinib and its active metabolite are 62.9-101 ng/ml, which are target concentrations predicted from preclinical data to inhibit receptor phosphorylation in vitro and result in tumour stasis/growth reduction in vivo.
Croatian: Do 14. dana kombinirane plazmatske koncentracije sunitiniba i njegova aktivnog metabolita iznose 62,9 - 101 ng/ml, što su ciljne koncentracije koje, prema podacima iz nekliničkih istraživanja, inhibiraju fosforilaciju receptora in vitro te rezultiraju stazom/smanjenjem rasta tumora in vivo.
English: If Sutent is used during pregnancy or if the patient becomes pregnant while on treatment with Sutent, the patient should be apprised of the potential hazard to the foetus.
Croatian: Ako se Sutent primjenjuje u trudnoći ili ako bolesnica zatrudni tijekom primjene lijeka, mora je se upozoriti na moguću opasnost za plod.
English: Women of childbearing potential should be advised to use effective contraception and avoid becoming pregnant while receiving treatment with Sutent.
Croatian: Ženama reproduktivne dobi treba savjetovati da koriste učinkovitu kontracepciju te izbjegavaju trudnoću za vrijeme liječenja lijekom Sutent.
English: Sunitinib is metabolised primarily by CYP3A4, the CYP isoform which produces its primary active metabolite, desethyl sunitinib, which is then further metabolised by the same isoenzyme.
Croatian: Sunitinib se prvenstveno metabolizira pomoću CYP3A4, izoformom enzima CYP koja proizvodi njegov primarni aktivni metabolit dezetilsunitinib, koji se dalje metabolizira uz pomoć istog izoenzima.
English: • Damage to the smallest blood vessels known as thrombotic microangiopathy (TMA).
Croatian: • Oštećenje najmanjih krvnih žila poznato kao trombotička mikroangiopatija (TMA).
English: The primary active metabolite comprises 23% to 37% of the total exposure.
Croatian: Od ukupne izloženosti lijeku, na glavni aktivni metabolit otpada 23% do 37%.
English: Moxifloxacin (400 mg) used as a positive control showed a 5.6 msec maximum mean QTcF interval change from baseline.
Croatian: Moksifloksacin (400 mg) koji se primjenjivao kao pozitivna kontrola iskazao je najveću srednju vrijednost promjene QTcF-intervala od 5,6 ms u odnosu na početne vrijednosti.
English: Severe cutaneous reactions have been reported, including cases of erythema multiforme (EM), cases suggestive of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), some of which were fatal.
Croatian: Prijavljene su teške kožne reakcije, uključujući slučajeve multiformnog eritema (EM), slučajeve koji upućuju na Stevens-Johnsonov sindrom (SJS) i toksičnu epidermalnu nekrolizu (TEN), od kojih su neki imali smrtni ishod.
English: Polyploidy (numerical chromosome aberrations) was observed in human peripheral blood lymphocytes in vitro, both in the presence and absence of metabolic activation.
Croatian: U ljudskim limfocitima u perifernoj krvi opažena je poliploidija (numeričke kromosomske aberacije) in vitro, i u prisutnosti i u odsutnosti metaboličke aktivacije.
English: Cases of serious infection (with or without neutropenia), including cases with fatal outcome, have been reported.
Croatian: Prijavljeni su slučajevi teških infekcija (sa ili bez neutropenije), uključujući prijavljene slučajeve sa smrtnim ishodom.
English: In the second part of the study, including patients with prior anticancer therapy but without risk factors for cardiac toxicity, sunitinib was generally tolerable and clinically manageable at the dose of 15 mg/m daily (MTD) on Schedule 4/2.
Croatian: U drugom dijelu ispitivanja, uključujući bolesnike na prethodnoj terapiji protiv raka, ali bez faktora rizika za kardiotoksičnost, sunitinib je općenito bio podnošljiv i klinički se mogao primjenjivati u dozi od 15 mg/m2 na dan (maksimalna podnošljiva doza) po shemi 4/2.
English: The risk of cardiac adverse drug reactions appeared to be higher in paediatric patients with previous exposure to cardiac irradiation or anthracycline compared to those paediatric patients without previous exposure.
Croatian: Rizik od srčanih nuspojava na lijek čini se većim u pedijatrijskih bolesnika koji su prethodno bili izloženi zračenju srca ili antraciklinu u usporedbi s pedijatrijskim bolesnicima bez prethodne izloženosti.
English: These may be symptoms of a condition called pulmonary embolism that occurs when blood clots travel to your lungs.
Croatian: To mogu biti simptomi plućne embolije do koje dolazi kada krvni ugrušci dospiju u pluća.
English: Sunitinib and its primary active metabolite were the major compounds identified in plasma, urine, and faeces, representing 91.5%, 86.4%, and 73.8% of radioactivity in pooled samples, respectively.
Croatian: Sunitinib i njegov primarni aktivni metabolit bili su glavni spojevi pronađeni u plazmi, mokraći i fecesu te predstavljaju 91,5% (plazma), 86,4% (mokraća) odnosno 73,8% (feces) radioaktivnosti u pulovima uzoraka.