FrancophonIA/ELRC3.0 huggingface dataset:
English: The mechanism leading to the formation of gastric carcinoids by substituted benzimidazoles has been carefully investigated and allows the conclusion that it is a secondary reaction to the massively elevated serum gastrin levels occurring in the rat during chronic high-dose treatment.
Slovenian: Mehanizem, ki privede do nastanka želodčnih karcinoidov s substituiranimi benzimidazoli so natančno preučili in zaključili, da gre za sekundarno reakcijo na močno povišan serumski gastrin, ki je posledica kroničnega zdravljenja z visokimi odmerki.
English: Hypersensitivity (including anaphylactic reactions and anaphylactic shock)
Slovenian: Bolezni imunskega sistema preobčutljivost (vključno z anafilaktičnimi reakcijami in anafilaktičnim šokom)
English: Special patient groups: - If you suffer from severe liver problems, the daily injection should be only 20 mg (half a vial).
Slovenian: Posebne skupine bolnikov: - Če imate hude težave z jetri, sme biti dnevni odmerek samo 20 mg pantoprazola (½ viale).
English: Treatment duration in Zollinger-Ellison syndrome and other pathological hypersecretory conditions is not limited and should be adapted according to clinical needs.
Slovenian: Trajanje zdravljenja Zollinger-Ellisonovega sindroma in drugih stanj s povečanim izločanjem kisline ni časovno omejeno in ga je treba prilagoditi kliničnim potrebam.
English: The main metabolic pathway is demethylation by CYP2C19 and other metabolic pathways include oxidation by CYP3A4.
Slovenian: Glavna metabolična pot je demetilacija s CYP2C19 in druge metabolične poti vključujejo oksidacijo s CYP3A4.
English: Do not use Protium after the expiry date, which is stated on the carton and the container after EXP.
Slovenian: Zdravila Protium ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in na viali poleg oznake EXP.
English: Stevens-Johnson syndrome; Lyell syndrome; Erythema multiforme; Photosensitivity
Slovenian: Lyellova bolezen; multiformni eritem; fotosenzitivnost
English: In patients with severe liver impairment, the liver enzymes should be monitored during therapy.
Slovenian: Pri bolnikih s hudo okvaro jeter je treba jetrne encime med zdravljenjem spremljati.
English: Pantoprazole
Slovenian: pantoprazol
English: If you get any of the following side effects, tell your doctor immediately, or contact the casualty department at your nearest hospital:
Slovenian: Če se pojavi katerikoli od naslednjih neželenih učinkov, takoj obvestite svojega zdravnika ali se posvetujte z nezgodnim oddelkom v najbližji bolnišnici:
English: The usual treatment period is one to two weeks.
Slovenian: Zdravljenje traja običajno en do dva tedna.
English: The frequency of possible side effects listed below is defined using the following convention: very common (affects more than 1 user in 10) common (affects 1 to 10 users in 100) uncommon (affects 1 to 10 users in 1,000) rare (affects 1 to 10 users in 10,000) very rare (affects less than 1 user in 10,000) not known (frequency cannot be estimated from the available data)
Slovenian: Pogostnost možnih spodaj naštetih neželenih učinkov je opredeljena v skladu s sledečo navedbo: zelo pogosti (pojavijo se pri več kot 1 od 10 bolnikov) pogosti (pojavijo se pri 1 do 10 od 100 bolnikov) občasni (pojavijo se pri 1 do 10 od 1.000 bolnikov) redki (pojavijo se pri 1 do 10 od 10.000 bolnikov) zelo redki (pojavijo se pri manj kot 1 od 10.000 bolnikov) neznana (pogostnosti ni mogoče oceniti iz razpoložljivih podatkov)
English: WHAT PROTIUM IS AND WHAT IT IS USED FOR Protium is a selective “proton pump inhibitor”, a medicine which reduces the amount of acid produced in your stomach.
Slovenian: KAJ JE ZDRAVILO PROTIUM IN ZA KAJ GA UPORABLJAMO Zdravilo Protium je selektivni »zaviralec protonske črpalke«, ki zmanjšuje količino proizvedene kisline v vašem želodcu.
English: Pantoprazole is rapidly absorbed and the maximal plasma concentration is achieved even after one single 20 mg oral dose.
Slovenian: Pantoprazol se hitro absorbira in doseže maksimalno koncentracijo v plazmi že po enkratnem 20 mg peroralnem odmerku.
English: Do not stop taking these tablets without first talking to your doctor or pharmacist.
Slovenian: Če ste prenehali jemati zdravilo Protium Ne prenehajte z jemanjem teh tablet, na da bi se prej pogovorili z zdravnikom ali s farmacevtom.
English: Although for patients with liver cirrhosis (classes A and B according to Child) the half-life values increased to between 3 and 6 h and the AUC values increased by a factor of 3 - 5, the maximum serum concentration only increased slightly by a factor of 1.3 compared with healthy subjects.
Slovenian: Čeprav se pri bolnikih z jetrno cirozo (razred A in B po Childu) razpolovni čas podaljša na 3-6 ur in AUC vrednosti narastejo s faktorjem 3-5, poraste maksimalna plazemska koncentracija komaj opazno, s faktorjem 1,3 v primerjavi z zdravimi osebami.
English: In the presence of any alarm symptom (e. g. significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena) and when gastric ulcer is suspected or present, malignancy should be excluded, as treatment with pantoprazole may alleviate symptoms and delay diagnosis.
Slovenian: Ob pojavu kateregakoli alarmantnega simptoma (npr. znatne nenamerne izgube telesne mase, ponavljajočega bruhanja, disfagije, hematemeze, anemije ali melene) ali v primeru suspektnega ali prisotnega želodčnega ulkusa je treba izključiti malignom, saj zdravljenje s pantoprazolom lahko zmanjša simptome in zakasni postavitev diagnoze.
English: Pantoprazole is rapidly absorbed and the maximal plasma concentration is achieved even after one single 40 mg oral dose.
Slovenian: Pantoprazol se hitro absorbira in doseže maksimalno koncentracijo v plazmi že po enkratnem 40 mg peroralnem odmerku.
English: A slight increase in AUC and Cmax in elderly volunteers compared with younger counterparts is also not clinically relevant.
Slovenian: Pri starejših prostovoljcih so v primerjavi z mladimi opazili rahel porast AUC in Cmax, vendar zvišanje klinično ni pomembno.
English: The main metabolic pathway is demethylation by CYP2C19 with subsequent sulphate conjugation, other metabolic pathway include oxidation by CYP3A4.
Slovenian: Glavna metabolična pot je demetilizacija s CYP2C19 in naknadna sulfatna konjugacija, druge metabolične poti vključujejo oksidacijo s CYP3A4.
English: Protium is a selective “proton pump inhibitor”, a medicine which reduces the amount of acid produced in your stomach.
Slovenian: Zdravilo Protium je selektivni »zaviralec protonske črpalke«, ki zmanjšuje količino proizvedene kisline v vašem želodcu.
English: Adults and adolescents 12 years of age and above Symptomatic gastro-oesophageal reflux disease.
Slovenian: Odrasli in mladostniki starejši od 12 let Simptomatska gastro-ezofagealna refluksna bolezen.
English: Serious skin conditions (frequency not known): blistering of the skin and rapid deterioration of your general condition, erosion (including slight bleeding) of eyes, nose, mouth/lips or genitals (Stevens-Johnson-Syndrome, Lyell-Syndrome, Erythema multiforme) and sensitivity to light.
Slovenian: - Resna kožna stanja (pogostnost neznana): mehurji na koži in hitro poslabšanje vašega splošnega stanja, razjede (vključno z rahlimi krvavitvami) okoli oči, nosa, ust/ustnic ali v predelu genitalij (Stevens-Johnson sindrom, Lyellova bolezen, multiformni eritem), občutljivost na svetlobo.
English: As a result, a mild to moderate increase in the number of specific endocrine (ECL) cells in the stomach is observed in a minority of cases during longterm treatment (simple to adenomatoid hyperplasia).
Slovenian: Kot posledica tega pride pri dolgotrajnem zdravljenju v manjšem številu primerov do rahlega ali zmernega porasta števila specifičnih želodčnih endokrinih (ECL) celic (enostavna do adenomatozna hiperplazija).
English: When symptom relief has been achieved, reoccurring symptoms can be controlled using an on-demand regimen of 20 mg once daily, when required.
Slovenian: Po umiritvi simptomov lahko ponovno pojavljanje simptomov obvladujemo z odmerjanjem 20 mg enkrat na dan po potrebi.
English: The fasting gastrin values increase under pantoprazole.
Slovenian: Vrednosti gastrina se po pantoprazolu na prazen želodec zvišajo.
English: For long-term management and for preventing the return of reflux oesophagitis The usual dose is one tablet a day.
Slovenian: Za dolgotrajno zdravljenje in preprečevanje ponovitve refluksnega ezofagitisa Običajen odmerek je 1 tableta na dan.
English: Hospital packs: 1 vial, 5 (5x1) vials, 10 (10x1) vials and 20 (20x1) vials with powder for solution for injection.
Slovenian: Bolnišnična pakiranja: 1 viala, 5 (5x1) vial, 10 (10x1) vial in 20 (20x1) vial s praškom za raztopino za injiciranje.
English: A temporary increase of the dose above 160 mg pantoprazole is possible but should not be applied longer than required for adequate acid control.
Slovenian: Začasno se lahko odmerek pantoprazola poveča tudi nad 160 mg, vendar jemanje tako visokih odmerkov ne sme trajati dlje, kot je potrebno za uravnavanje izločanja kisline.
English: Children below 12 years of age
Slovenian: Otroci mlajši od 12 let
English: twice daily one tablet Protium + twice daily 400 - 500 mg metronidazole (or 500 mg tinidazole) + twice daily 250 - 500 mg clarithromycin c) twice daily one tablet Protium + twice daily 1000 mg amoxicillin + twice daily 400 - 500 mg metronidazole (or 500 mg tinidazole)
Slovenian: a) dvakrat na dan eno tableto zdravila Protium 40 mg gastrorezistentne tablete + dvakrat na dan 1000 mg amoksicilina + dvakrat na dan 500 mg klaritromicina b) dvakrat na dan eno tableto zdravila Protium 40 mg gastrorezistentne tablete + dvakrat na dan 400 - 500 mg metronidazola (ali 500 mg tinidazola) + dvakrat na dan 250 - 500 mg klaritromicina c) dvakrat na dan eno tableto zdravila Protium 40 mg gastrorezistentne tablete + dvakrat na dan 1000 mg amoksicilina + dvakrat na dan 400 - 500 mg metronidazola (ali 500 mg tinidazola)
English: Core: sodium carbonate (anhydrous), mannitol, crospovidone, povidone K90, calcium stearate.
Slovenian: Jedro: natrijev karbonat (brezvodni), manitol, krospovidon, povidon K90, kalcijev stearat.
English: A daily dose of 20 mg pantoprazole (half a vial of 40 mg pantoprazole) should not be exceeded in patients with severe liver impairment (see section 4.4).
Slovenian: Dnevnega odmerka 20 mg pantoprazola (ena polovica viale 40 mg pantoprazola) se ne sme preseči pri bolnikih s hudo okvaro jeter (glejte poglavje 4.4).
English: The occurrence of these neoplasms is associated with the pantoprazole-induced changes in the breakdown of thyroxine in the rat liver.
Slovenian: Pojavnost teh neoplazem je združena s spremenjeno razgradnjo tiroksina v jetrih podgan, ki jo povzroča pantoprazol.
English: In addition, squamous cell papillomas were found in the forestomach of rats.
Slovenian: Poleg tega so v predželodcu podgan odkrili skvamozne celične papilome.
English: Very Rare (affects less than 1 user in 10,000) disorientation.
Slovenian: - Zelo redki (pojavijo se pri manj kot 1 od 10.000 bolnikov) neorientiranost.
English: Any product that has remained in the container or the visual appearance of which has changed (e.g. if cloudiness or precipitation is observed) should be disposed of in accordance with local requirements.
Slovenian: Ostanek raztopine v viali ali raztopino spremenjenega videza (npr. če se opazi motnost ali usedlina) je potrebno zavreči v skladu z lokalnimi predpisi.
English: In patients with severe liver impairment the liver enzymes should be monitored regularly during treatment with pantoprazole, particularly on long-term use.
Slovenian: Pri bolnikih s hudo okvaro jeter je treba pri zdravljenju s pantoprazolom, posebno pri dolgotrajnem zdravljenju, redno spremljati jetrne encime.
English: The treatment period for stomach ulcers is usually between 4 and 8 weeks.
Slovenian: Obdobje zdravljenja želodčnih razjed traja običajno 4 do 8 tednov.
English: The active substance is pantoprazole.
Slovenian: Zdravilna učinkovina je pantoprazol.
English: With doses above 80 mg daily, the dose should be divided and given twice daily.
Slovenian: Pri dnevnih odmerkih nad 80 mg je treba odmerek razdeliti in ga zaužiti dvakrat na dan.
English: Take special care with Protium
Slovenian: Bodite posebno pozorni pri zdravilu Protium
English: Name of Member State
Slovenian: Ime države članice Ime zdravila Avstrija
English: Interaction studies have also been performed administering pantoprazole concomitantly with the respective antibiotics (clarithromycin, metronidazole, amoxicillin) No clinically relevant interactions were found.
Slovenian: Narejene so bile tudi študije medsebojnega delovanja ob sočasnem jemanju pantoprazola in ustreznega antibiotika (klaritromicina, metronidazola, amoksicilina).
English: Disturbances in vision / blurred vision
Slovenian: Očesne bolezni motnje vida / nejasen vid
English: In combination therapy for eradication of H. pylori infection, the second Protium tablet should be taken 1 hour before the evening meal.
Slovenian: Pri kombiniranem zdravljenju za eradikacijo infekcije s H. pylori moramo vzeti drugo tableto zdravila Protium 40 mg gastrorezistentne tablete 1 uro pred večerjo.
English: Important information about some of the ingredients of Protium Protium contains soya oil.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Protium Zdravilo Protium vsebuje sojino olje.
English: Important information about some of the ingredients of Protium This medicine contains less than 1 mmol sodium (23 mg) per vial, i.e. is essentially ‘sodium- free'.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Protium To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na 1 vialo, kar v bistvu pomeni »brez natrija«.
English: A pantoprazole dose of 20 mg per day should not be exceeded.
Slovenian: Odmerek pantoprazola ne sme preseči 20 mg na dan.
English: Rare (affects 1 to 10 users in 10,000) an increase in bilirubin; increased fats in the blood.
Slovenian: - Redki (pojavijo se pri 1 do 10 od 10.000 bolnikov) povečane vrednosti bilirubina; povišane maščobe v krvi.
English: doses of 0.8 or 1.6 mg/kg pantoprazole to children aged 2 - 16 years there was no significant association between pantoprazole clearance and age or weight.
Slovenian: odmerkih 0,8 ali 1,6 mg/kg pantoprazola pri otrocih v starosti 2-16 let ni bilo statistično pomembne povezave med očistkom pantoprazola in starostjo ali telesno maso.
English: Characteristics in patients/special groups of subjects Approximately 3 % of the European population lack a functional CYP2C19 enzyme and are called poor metabolisers.
Slovenian: Približno 3 % evropskega prebivalstva nima delujočega encima CYP2C19 in jih imenujemo šibki presnavljalci.
English: Long-term management of reflux oesophagitis (inflammation of the oesophagus accompanied by the regurgitation of stomach acid) and preventing its return.
Slovenian: - Dolgotrajno zdravljenje refluksnega ezofagitisa (vnetje požiralnika, ki ga spremlja regurgitacija želodčne kisline) in preprečevanje ponovitve.
English: - If you have reduced body stores or risk factors for reduced vitamin B12 and receive pantoprazole long-term treatment.
Slovenian: - če imate zmanjšane telesne zaloge ali dejavnike tveganja za zmanjšano absorpcijo vitamina B12 in se dolgotrajno zdravite s pantoprazolom.
English: Powder for solution for injection.
Slovenian: prašek za raztopino za injiciranje
English: As with all acid reducing agents, pantoprazole may lead to a reduced absorption of vitamin B12.
Slovenian: Kot vsa zdravila, ki zavirajo izločanje kisline, lahko pantoprazol zmanjša absorpcijo vitamina B12.
English: Effect of pantoprazole on the absorption of other medicinal products Because of profound and long lasting inhibition of gastric acid secretion, pantoprazole may reduce the absorption of drugs with a gastric pH dependent bioavailability, e.g some azole antifungals as ketoconazole, itraconazole, posaconazole and other medicine as erlotinib.
Slovenian: Učinek pantoprazola na absorpcijo drugih zdravil Zaradi temeljitega in dolgotrajnega zaviranja izločanja želodčne kisline lahko pantoprazol zmanjša absorpcijo zdravil, katerih biološka razpoložljivost je odvisna od pH, npr. nekateri azolni antimikotiki kot ketokonazol, itrakonazol, posakonazol in druga zdravila kot je erlotinib.
English: If this is not sufficient, symptom relief will normally be achieved within a further 4 weeks.
Slovenian: Kadar to ne zadošča, navadno dosežemo olajšanje simptomov v naslednjih 4 tednih.
English: Preclinical data reveal no special hazard to humans based on conventional studies of safety pharmacology, repeated dose toxicity and genotoxicity.
Slovenian: Predklinični podatki na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih in genotoksičnosti ne kažejo posebnega tveganja za človeka.
English: Adults and adolescents 12 years of age and above
Slovenian: Odrasli in mladostniki starejši od 12 let
English: In case a rapid acid control is required, a starting dose of 2 x 80 mg Protium is sufficient to manage a decrease of acid output into the target range (<10 mEq/h) within one hour in the majority of patients.
Slovenian: Izločanje kisline lahko po potrebi zelo hitro uravnamo z začetnim odmerkom 2x 80 mg pantoprazola, saj takšen odmerek pri večini bolnikov že v eni uri zmanjša izločanje kisline do ciljnega območja vrednosti (<10mEq/h).
English: Use the reconstituted and diluted solution within 12 hours.
Slovenian: Pripravljeno in razredčeno raztopino uporabite v 12 urah.
English: This should be considered in patients with reduced body stores or risk factors for reduced vitamin B12 absorption on long-term therapy or if respective clinical symptoms are observed.
Slovenian: To je treba upoštevati pri dolgotrajnem zdravljenju bolnikov z zmanjšanimi telesnimi zalogami ali z dejavniki tveganja za zmanjšano absorpcijo vitamina B12 ali če se opazijo odgovarjajoči klinični simptomi.
English: There are no known symptoms of overdose.
Slovenian: Znaki prevelikega odmerjanja niso znani.
English: Pantecta 20 mg comprimidos gastrorresistentes Blister, Anagastra 20 mg Blister, Ulcotenal 20 mg comprimidos gastrorresistentes Blister Pantoloc
Slovenian: Controloc 20 mg gastrorezistentne tablete Pantecta 20 mg comprimidos gastrorresistentes Blister, Anagastra 20 mg Blister, Ulcotenal 20 mg comprimidos gastrorresistentes Blister Pantoloc
English: Confusion (especially in pre-disposed patients, as well as the aggravation of these symptoms in case of preexistence)
Slovenian: halucinacije; zmedenost (predvsem pri bolnikih s predispozicijami pa tudi poslabšanje teh simptomov, kadar so že prisotni )
English: Therefore, the co-administration of proton pump inhibitors with atazanavir is not recommended (see section 4.4).
Slovenian: Zato sočasno jemanje zaviralcev protonske črpalke z atazanavirjem ni priporočljivo (glejte poglavje 4.4).
English: Protium is not recommended for use in children below 12 years of age due to limited data on safety and efficacy in this age group.
Slovenian: Uporaba Protium 40 mg gastrorezistentnih tablet pri otrocih pod 12 let ni priporočljiva zaradi nezadostnih podatkov o varnosti in učinkovitosti v tej starostni skupini.
English: HDPE bottles with LDPE screw cap closure.
Slovenian: HDPE plastenke z LDPE navojno zaporko s:
English: The medicine should be administered intravenously over 2-15 minutes.
Slovenian: Intravensko injiciranje zdravila mora trajati 2-15 minut.
English: the maximum serum concentrations of about 1-1.5 µg/ml are achieved, and these values remain constant after multiple administration.
Slovenian: V povprečju dosežemo maksimalno plazemsko koncentracijo 1-1,5 μg/ml v 22,5 urah po zaužitju in te vrednosti ostanejo po večkratnem vnosu konstantne.
English: Symptom relief is generally accomplished within 2-4 weeks.
Slovenian: Običajno dosežemo olajšanje simptomov v 2 - 4 tednih.
English: Following administration of single intravenous doses of 0.8 or 1.6 mg/kg pantoprazole to children aged 2 - 16 years there was no significant association between pantoprazole clearance and age or weight.
Slovenian: Po enkratnih intravenskih odmerkih 0,8 ali 1,6 mg/kg pantoprazola pri otrocih v starosti 2-16 let ni bilo statistično pomembne povezave med očistkom pantoprazola in starostjo ali telesno maso.
English: Hospital pack with
Slovenian: Bolnišnično pakiranje s:
English: Protium is a white to off-white powder for solution for injection.
Slovenian: Zdravilo Protium je bel do umazano bel prašek za raztopino za injiciranje.
English: The other ingredients are: disodium edetate and sodium hydroxide (for pH adjustment).
Slovenian: - Pomožne snovi so: dinatrijev edetat, natrijev hidroksid (za uravnavanje pH).
English: Keep the vial in the outer carton in order to protect from light.
Slovenian: Za zagotovitev zaščite pred svetlobo shranjujte vialo v zunanji ovojnini.
English: Pantoprazole is a substituted benzimidazole which inhibits the secretion of hydrochloric acid in the stomach by specific blockade of the proton pumps of the parietal cells.
Slovenian: Pantoprazol je substituiran benzimidazol, ki zavira izločanje klorovodikove kisline v želodcu s specifičnim delovanjem na protonsko črpalko parietalnih celic .
English: Pantoprazole is converted to its active form in the acidic environment in the parietal cells where it inhibits the H+, K+-ATPase enzyme, i.e. the final stage in the production of hydrochloric acid in the stomach.
Slovenian: Pantoprazol se pretvori v svojo aktivno obliko v kislem okolju parietalnih celic, kjer zavira H+, K+ ATPazni encim, to je končno stopnjo v tvorbi klorovodikove kisline v želodcu.
English: There are no known symptoms of overdose in man.
Slovenian: Znaki prevelikega odmerjanja pri človeku niso znani.
English: Pack with 5 (5x1) vials.
Slovenian: Pakiranje s 5 (5x1) vialami.
English: Packs: bottles (high density polyethylene container with low density polyethylene screw cap closure) and blister (ALU/ALU blister) without cardboard reinforcement or with cardboard reinforcement (blister wallet).
Slovenian: Pakiranja: plastenke (vsebnik iz polietilena visoke gostote z navojno zaporko iz polietilena nizke gostote) in pretisni omot (ALU/ALU pretisni omot) brez kartonske opore ali s kartonsko oporo (oblika listnice).
English: Following administration of single i.v.
Slovenian: Po enkratnih i.v.
English: In patients with Zollinger-Ellison syndrome and other pathological hypersecretory conditions requiring long-term treatment, pantoprazole, as all acid-blocking medicines, may reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria.
Slovenian: Pri bolnikih z Zollinger-Ellisonovim sindromom in drugimi stanji povečanega izločanja želodčne kisline, ki potrebujejo dolgotrajno zdravljenje, lahko pantoprazol kot vsa druga zdravila, ki zavirajo izločanje kisline, zmanjša absorpcijo vitamina B12 (ciankobalamina) zaradi hipo- oziroma aklorhidrije.
English: These doses are carefully checked by your nurse or your doctor so an overdose is extremely unlikely.
Slovenian: Če ste uporabili večji odmerek zdravila Protium, kot bi smeli Odmerke natačno preverita medicinska sestra ali zdravnik, zato je predoziranje nadvse malo verjetno.
English: Tell your doctor immediately if you notice any of the following symptoms: - an unintentional loss of weight - repeated vomiting - difficulty in swallowing - vomiting blood - you look pale and feel weak (anaemia) - you notice blood in your stools - severe and/or persistent diarrhoea, as Protium has been associated with a small increase in infectious diarrhoea.
Slovenian: Takoj obvestite svojega zdravnika, če opazite kateregakoli od spodaj navedenih simptomov: - nenamerna izguba telesne mase - ponavljajoče bruhanje - težave pri požiranju - bruhanje krvi - če ste bledi in slabotni (slabokrvni) - opažate kri v blatu - resna in/ali stalna driska, ker je zdravilo Protium povezano z blagim povečanjem pojavnosti infekcijskih drisk.
English: - If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor.
Slovenian: - Če katerikoli neželeni učinek postane resen ali če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.