FrancophonIA/ELRC3.0 huggingface dataset:
English: Combination with metformin is associated with an increased risk of hypoglycaemia compared to monotherapy.
Danish: Kombination med metformin associeres med øget risiko for hypoglykæmi sammenlignet med monoterapi.
English: M1 concentration decreased markedly after haemodialysis.
Danish: M1-koncentrationen faldt markant efter hæmodialyse.
English: - Sympathomimetics (used, for example, to treat asthma).
Danish: - Sympatomimetika (bruges f.eks. til at behandle astma).
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential and toxicity to fertility and post-natal development.
Danish: Prækliniske data viser ingen speciel risiko for mennesker vurderet ud fra konventionelle studier af sikkerhedsfarmakologi, toksicitet efter gentagne doser, genotoksicitet, karcinogenicitet samt reproduktions- og udviklingstoksicitet.
English: Similarly, there was no clinically significant pharmacokinetic interaction of Starlix with other oral antidiabetic agents such as metformin or glibenclamide.
Danish: Ligeledes var der ingen klinisk signifikant farmakokinetisk interaktion mellem Starlix og andre orale antidiabetiske lægemiddelstoffer såsom metformin og glibenclamid.
English: Talk to your doctor, pharmacist or nurse before taking Starlix.
Danish: Kontakt lægen, apotekspersonalet eller sundhedspersonalet før du tager Starlix.
English: What Starlix is The active substance of Starlix, nateglinide, belongs to a group of medicines called oral antidiabetics.
Danish: Hvad Starlix er Det aktive stof i Starlix, nateglinid, tilhører en gruppe af lægemidler, der kaldes orale antidiabetika.
English: The decrease from baseline in HbA1c was -0.41% in the nateglinide plus metformin group and -0.57% in the gliclazide plus metformin group (difference 0.17%, [95% CI -0.03, 0.36]).
Danish: Formindskelsen af HbA1c fra baseline var -0,41% i nateglinid plus metformin gruppen og -0,57% i gliclazid plus metformin gruppen (forskel 0,17%, [95% KI -0,03, 0,36]).
English: The effect of Starlix on the ability to drive or operate machinery has not been studied.
Danish: Der er ikke foretaget undersøgelser af Starlix' virkning på evnen til at føre motorkøretøj eller betjene maskiner.
English: Nateglinide, when taken before a meal, restores early or first phase insulin secretion, which is lost in patients with type 2 diabetes, resulting in a reduction in post-meal glucose and HbA1c.
Danish: Når nateglinid indtages før et måltid, genetableres den tidlige eller førstefase insulinsekretion, som ikke eksisterer hos patienter med type 2 diabetes, hvilket medfører reduktion af postprandial glukose og HbA1c.
English: - if you have problems with drug metabolism.
Danish: - hvis du har problemer med nedbrydning af medicin.
English: - Diuretics (used to treat high blood pressure).
Danish: - Diuretika (anvendes til at behandle for højt blodtryk).
English: Patients should be advised to take precautions to avoid hypoglycaemia whilst driving.
Danish: Patienterne bør rådes til at tage særlige forholdsregler for at undgå hypoglykæmi under bilkørsel.
English: In completed clinical trials, symptoms of hypoglycaemia were reported in 10.4% with nateglinide monotherapy, 14.5% with nateglinide+metformin combination, 6.9% with metformin alone, 19.8% with glibenclamide alone, and 4.1% with placebo.
Danish: I afsluttede kliniske undersøgelser blev symptomer på hypoglykæmi rapporteret i 10,4% af tilfældene med nateglinid monoterapi, 14,5% med nateglinid og metformin i kombination, 6,9% med metformin alene, 19,8% med glibenclamid alene og 4,1% med placebobehandling.
English: The efficacy of nateglinide in combination with metformin has been compared to the combination of gliclazide plus metformin in a 6-month randomised, double-blind trial in 262 patients using a superiority design.
Danish: Nateglinids virkning i kombination med metformin er blevet sammenlignet med kombinationen af gliclazid og metformin i et 6 måneders randomiseret, dobbelt-blindt studie i 262 patienter, hvor et superiority design blev anvendt.
English: Starlix tablets start to act within a very short time after they are swallowed and are eliminated from the body rapidly.
Danish: Starlix tabletterne begynder at virke meget kort tid efter at du har slugt dem, og stoffet udskilles hurtigt fra kroppen.
English: If you do get symptoms of low blood sugar, eat or drink something containing sugar.
Danish: Hvis du får symptomer på lavt blodsukker, skal du spise eller drikke noget, der indeholder sukker.
English: Plasma concentrations decline rapidly and the elimination half-life of nateglinide typically averaged 1.5 hours in all studies of Starlix in volunteers and type 2 diabetic patients.
Danish: Plasmakoncentrationerne falder hurtigt, og nateglinids elimineringshalveringstid var gennemsnitligt typisk på 1,5 timer i alle undersøgelser af Starlix med frivillige forsøgspersoner og type 2 diabetikere.
English: It is recommended that Starlix be administered prior to meals.
Danish: Det anbefales, at Starlix indgives før måltiderne.
English: These are symptoms of low blood sugar (hypoglycaemia), which are usually mild.
Danish: Følgende er symptomer på lavt blodsukker (hypoglykæmi), som normalt er lette.
English: C] nateglinide is recovered in the urine within six hours post-dose.
Danish: C nateglinid findes i urinen inden for seks timer efter administration.
English: Common: Symptoms suggestive of hypoglycaemia.
Danish: Almindelige: Symptomer på hypoglykæmi.
English: and 180 mg tablets) or yellow (120 mg tablets) iron oxide (E172).
Danish: og 180 mg tabletters) eller gul (120 mg tabletter) jernoxid (E172).
English: Oral antidiabetics, including Starlix, may also produce symptoms of hypoglycaemia.
Danish: Orale anidiabetika, herunder Starlix, kan også give symptomer på hypoglykæmi.
English: Your doctor will prescribe Starlix together with metformin, if inadequately controlled despite a maximally tolerated dose of metformin.
Danish: Din læge vil ordinere Starlix sammen med metformin, hvis kontrollen ikke er tilstrækkelig, på trods af at du får den maksimale tolererede dosis af metformin.
English: Rare: Hypersensitivity reactions such as rash, itching and urticaria.
Danish: Sjældne: Overfølsomhedsreaktioner som udslæt, kløe og urticaria.
English: Particular caution is recommended when nateglinide is co-administered with other more potent inhibitors of CYP2C9 (e.g. fluconazole, gemfibrozil or sulfinpyrazone), or in patients known to be poor metabolisers for CYP2C9 substrates.
Danish: Særlig forsigtighed anbefales når nateglinid administreres sammen med andre mere potente CYP2C9hæmmere (f.eks. fluconazol, gemfibrozil eller sulfinpyrazon), eller hos patienter, der er kendt for at være dårlige til at metabolisere CYP2C9-substrater.
English: Most of the [14C] nateglinide is excreted in the urine (83%), with an additional 10% eliminated in the faeces.
Danish: C nateglinid udskilles i urinen (83%), mens yderligere 10% elimineres gennem fæces.
English: If you have low blood sugar you may experience sweating, tremors (feeling shaky), anxiety, difficulty concentrating, confusion, weakness or fainting or have other signs listed in section 4, “Possible side effects”.
Danish: Hvis du har lavt blodsukker, kan du opleve at svede, rysten (tremor), angst, koncentrationsbesvær, forvirring, svaghed, at du besvimer eller opleve andre af de symptomer, der er nævnt i pkt.
English: - St. John's Wort, also known as Hypericum perforatum (a herbal medicine).
Danish: - Perikon, også kendt som Hypericum perforatum (et naturlægemiddel).
English: Nateglinide closes ATP-dependent potassium channels in the beta-cell membrane with characteristics that distinguish it from other sulphonylurea receptor ligands.
Danish: Nateglinid lukker ATP-afhængige kaliumkanaler i den β-cellemembran, der har karakteristika, der adskiller den fra andre sulfonylurinreceptorligander.
English: - Anabolic hormones (e.g. methandrostenolone).
Danish: - Anaboliske hormoner (fx methandrostenolon).
English: Common: Abdominal pain, diarrhoea, dyspepsia, nausea.
Danish: Almindelige: Abdominalsmerter, diarré, dyspepsi, kvalme.
English: No clinically significant differences in nateglinide pharmacokinetics were observed between men and women.
Danish: Der er ikke blevet observeret klinisk signifikante forskelle i nateglinids farmakokinetisk mellem mænd og kvinder.
English: - Somatostatin analogues such as lanreotide and octreotide (used to treat acromegaly).
Danish: - Somatostatin-analoger som lanreotid og octreotid (bruges til at behandle akromegali).
English: How Starlix works
Danish: Hvordan Starlix virker
English: In rabbits, embryonic development was adversely affected and the incidence of gallbladder agenesis or small gallbladder was increased at doses of 300 and 500 mg/kg (approximately 24 and 28 times the human therapeutic exposure with a maximum recommended nateglinide dose of 180 mg, three times daily before meals), but not at 150 mg/kg (approximately 17 times the human therapeutic exposure with a maximum recommended nateglinide dose of 180 mg, three times daily before meals).
Danish: Hos kaniner blev fosterudviklingen påvirket negativt, og hyppigheden af galdeblære-agenesi eller lille galdeblære var forøget ved doser på 300 og 500 mg/kg (ca. 24 og 28 gange den humane eksponering ved den maksimalt anbefalede dosis på 180 mg nateglinid tre gange daglig før et måltid), men ikke ved 150 mg/kg (ca. 17 gange den humane eksponering ved den maksimalt anbefalede dosis på 180 mg nateglinid tre gange daglig før et måltid).
English: - if you are pregnant or planning to become pregnant.
Danish: - hvis du er gravid eller påtænker at blive det. - hvis du ammer.
English: When these medicinal products - that enhance or reduce the hypoglycaemic effect of nateglinide - are administered to or withdrawn from patients receiving nateglinide, the patient should be observed closely for changes in glycaemic control.
Danish: Hvis behandling med disse lægemidler, der øger eller reducerer nateglinids hypoglykæmiske virkning, påbegyndes eller seponeres hos patienter i behandling med nateglinid, skal patienten observeres omhyggeligt for ændringer i den glykæmiske kontrol.
English: - if you know that you have a severe liver problem.
Danish: - hvis du ved, at du har en svær leverlidelse.
English: Do not breast-feed during treatment with Starlix.
Danish: Du må ikke amme, mens du er i behandling med Starlix.
English: - The tablet coating contains hypromellose; titanium dioxide (E171); talc; macrogol and red (60
Danish: - Tabletovertrækket indeholder hypromellose; titandioxid (E171); talcum; macrogol og rød (60
English: Lactose monohydrate Cellulose, microcrystalline Povidone
Danish: Lactosemonohydrat Cellulose, mikrokrystallinsk Povidon
English: If you miss a meal, skip that dose of Starlix and wait until your next meal.
Danish: Hvis du springer et hovedmåltid over, skal du ikke tage den tilsvarende dosis Starlix, men vente til næste måltid.
English: - if you have a severe kidney problem.
Danish: - hvis du har alvorlige nyreproblemer.
English: Other adverse events observed in clinical studies were of a similar incidence in Starlix-treated and placebo-treated patients.
Danish: Øvrige bivirkninger i kliniske undersøgelser havde samme incidens hos Starlix-behandlede som hos placebobehandlede patienter.
English: Each tablet contains 60, 120 or 180 mg nateglinide.
Danish: Hver tablet indeholder 60, 120 eller 180 mg nateglinid.
English: croscarmellose sodium; magnesium stearate and silica, colloidal anhydrous.
Danish: croscarmellosenatrium; magnesiumstearat og silica, kolloid vandfri.
English: In patients with type 2 diabetes who were given Starlix with a dose range of 60 mg to 240 mg before meals three times a day for one week, nateglinide showed linear pharmacokinetics for both AUC and Cmax.
Danish: Hos patienter med type 2 diabetes, der fik en dosis Starlix på 60-240 mg før et måltid 3 gange dagligt i en uge, viste nateglinid lineære farmakokinetiske egenskaber for både AUC og Cmax, og tmax var uafhængig af dosis.
English: - The other ingredients are lactose monohydrate; cellulose, microcrystalline; povidone;
Danish: - Øvrige indholdsstoffer: lactosemonohydrat; cellulose, mikrokrystallinsk; povidon;
English: What Starlix contains - The active substance is nateglinide.
Danish: Starlix indeholder: - Aktivt stof: nateglinid.
English: In combination with metformin, which mainly affected fasting plasma glucose, the effect of nateglinide on HbA1c was additive compared to either agent alone.
Danish: I kombination med metformin, som primært påvirker fasteplasmaglukose, var virkningen på HbA1c additiv sammenlignet med begge stoffer hver for sig.
English: Each blister pack contains 12, 24, 30, 60, 84, 120 or 360 tablets.
Danish: Hver blisterpakning indeholder 12, 24, 30, 60, 84, 120 eller 360 tabletter.
English: Nateglinide efficacy was inferior to that of metformin in monotherapy (decrease in HbA1c (%) with metformin 500 mg three times daily monotherapy: -1.23 [95% CI: -1.48; -0.99] and with nateglinide 120 mg three times daily monotherapy -0.90 [95% CI: -1.14; -0.66]).
Danish: Nateglinids virkning i monoterapi var mindre end metformins (fald i HbA1c (%) med 500 mg metformin 3 gange daglig i monoterapi: -1,23 [95% CI: -1,48; -0,99] og med nateglinid 120 mg 3 gange daglig i monoterapi: -0,90 [95% CI: -1,14; -0,66]).
English: If this happens to you, eat or drink something containing sugar, and talk to your doctor.
Danish: Hvis du oplever nogen af disse symptomer, skal du spise eller drikke noget, der indeholder sukker og kontakte din læge.
English: Starlix, like other oral antidiabetic agents, must not be used in pregnancy.
Danish: Ligesom andre orale antidiabetika må Starlix ikke anvendes under graviditet.
English: Conversely, these medicinal products had no effect on the pharmacokinetics of nateglinide.
Danish: Omvendt havde disse stoffer ingen virkning på nateglinids farmakokinetiske egenskaber.
English: Packs contain 12, 24, 30, 60, 84, 120 and 360 tablets.
Danish: Pakninger med 12, 24, 30, 60, 84, 120 og 360 tabletter.
English: • Pregnancy and breast-feeding (see section 4.6)
Danish: • Graviditet og amning (se pkt.
English: - Corticosteroids such as prednisone and cortisone (used to treat inflammatory disorders).
Danish: - Kortikosteroider som prednison og kortison (anvendes til behandling af inflammationstilstande).
English: Elderly Age did not influence the pharmacokinetic properties of nateglinide.
Danish: Ældre Alder havde ingen indflydelse på nateglinids farmakokinetiske egenskaber.
English: Thus, no dosage adjustment is required for digoxin, warfarin or other drugs that are CYP2C9 or CYP3A4 substrates upon coadministration with Starlix.
Danish: Det er derfor ikke er nødvendigt med dosisjustering af digoxin, warfarin eller andre lægemidler, der er substrater for CYP2C9 eller CYP3A4, ved samtidig indgift af Starlix.
English: 12 film-coated tablets 24 film-coated tablets 30 film-coated tablets 60 film-coated tablets 84 film-coated tablets 120 film-coated tablets 360 film-coated tablets
Danish: 12 filmovertrukne tabletter 24 filmovertrukne tabletter 30 filmovertrukne tabletter 60 filmovertrukne tabletter 84 filmovertrukne tabletter 120 filmovertrukne tabletter 360 filmovertrukne tabletter
English: Starlix tablets contain lactose monohydrate.
Danish: Starlix tabletter indeholder lactosemonohydrat.
English: Repeated dosing with 90 mg once daily for 1 to 3 months in diabetic patients with end-stage renal disease (ESRD) showed pronounced M1 metabolite accumulation up to 1.2 ng/ml despite the reduced dose.
Danish: På trods af den reducerede dosis, viste gentagen dosering af 90 mg en gang dagligt i 1 til 3 måneder hos diabetiske patienter med nyresygdom i slutstadiet (ESRD), udtalt akkumulering af M1-metabolit op til 1,2 ng/ml.
English: Diuretics, corticosteroids, beta2 agonists, somatropin, somatostatin analogues, rifampin, phenytoin and St. John's Wort (Hypericum perforatum)
Danish: Diuretika, kortikosteroider, β2-agonister, somatropin, somatostatin-analoger, rifampicin, phenytoin og perikon (Hypericum perforatum)
English: Interaction studies with a CYP3A4 inhibitor have not been carried out in vivo.
Danish: Der har ikke været udført in vivo interaktionsstudier med CYP3A4-hæmmere.
English: Combination with ACE-inhibitors, NSAIDs, salicylates, monoamine oxidase inhibitors, non-selective beta-adrenergic-blocking agents and anabolic hormones
Danish: Kombination med ACE-hæmmere, NSAID-præparater, salicylater, monoaminoxidase-hæmmere, nonselektive beta-blokkere og anaboliske hormoner
English: • Uncommon (may affect up to 1 in 100 people): vomiting
Danish: • Ikke almindelig (kan forekomme hos op til 1 ud af 100 personer): opkastning
English: Although there is a 49% decrease in Cmax of nateglinide in dialysis patients, the systemic availability and half-life in diabetic subjects with moderate to severe renal insufficiency (creatinine clearance 15-50 ml/min) was comparable between renal subjects requiring haemodialysis and healthy subjects.
Danish: Selv om der er et fald på 49 % i Cmax for nateglinid hos dialysepatienter, kunne den systemiske tilgængelighed og halveringstiden hos diabetikere med moderat til svært nedsat nyrefunktion (kreatininclearance 15-50 ml/min) sammenlignes for hæmodialysekrævende nyrepatienter og raske personer.
English: If you stop taking Starlix
Danish: Hvis du holder op med at tage Starlix
English: The following agents may enhance the hypoglycaemic effect of nateglinide: angiotensin-converting enzyme inhibitors (ACEI), non-steroidal anti-inflammatory agents, salicylates, monoamine oxidase inhibitors, non-selective beta-adrenergic-blocking agents and anabolic hormones (e.g. methandrostenolone).
Danish: Følgende lægemiddelgrupper kan øge nateglinids hypoglykæmiske virkning: Angiotensinkonverterende enzymhæmmere (ACE-hæmmere), non-steroide antiinflammatoriske midler, salicylater, monoaminooxidase-hæmmere, non-selektive beta-blokkere og anaboliske hormoner (f.eks. methandrostenolon).
English: Starlix contains lactose
Danish: Starlix indeholder lactose
English: Severe hepatic impairment, children and adolescents No clinical studies have been conducted in patients with severe hepatic impairment, or in children and adolescents.
Danish: Der er ikke udført kliniske studier hos patienter med svært nedsat leverfunktion eller hos børn og unge.
English: - Rifampin (used, for example, to treat tuberculosis).
Danish: - Rifampicin (bruges fx til at behandle tuberkulose).
English: • Common (may affect up to 1 in 10 people): abdominal pain, indigestion, diarrhoea, nausea
Danish: • Almindelig (kan forekomme hos op til 1 ud af 10 personer): mavesmerter, forstoppelse, diarré, kvalme
English: If you forget to take Starlix
Danish: Hvis du har glemt at tage Starlix
English: Do not use any Starlix pack that is damaged or shows signs of tampering.
Danish: Anvend ikke Starlix, hvis emballagen er beskadiget eller brudt.
English: The following agents may reduce the hypoglycaemic effect of nateglinide: diuretics, corticosteroids, beta2 agonists, somatropin, somatostatin analogues (e.g. lanreotide, octreotide), rifampin, phenytoin and St. John's Wort (Hypericum perforatum).
Danish: Følgende lægemiddelgrupper kan reducere nateglinids hypoglykæmiske virkning: Diuretika, kortikosteroider, β2-agonister, somatropin, somatostatin-analoger (f.eks. lanreotid, octreotid), rifampicin, phenytoin og perikon (Hypericum perforatum).
English: The recommended starting dose of Starlix is 60 mg three times daily, taken before each of the three main meals.
Danish: Den anbefalede startdosis af Starlix er 60 mg tre gange daglig, taget før hvert af de tre hovedmåltider.
English: What you need to know before you take Starlix
Danish: Det skal du vide, før du begynder at tage Starlix
English: - if you have another medical condition that may cause low blood sugar (e.g. an under-active pituitary or adrenal gland).
Danish: - hvis du har andre lidelser, som kan give lavt blodsukker (f.eks. nedsat hypofyse- eller binyrefunktion).
English: • hunger
Danish: • sultfornemmelse
English: Uncommon: Vomiting.
Danish: Usædvanlig: Opkastning.
English: Always take this medicine exactly as your doctor, pharmacist or nurse has told you.
Danish: Tag altid lægemidlet nøjagtigt efter lægens, apotekspersonalets eller sunhedspersonalets anvisning.
English: Rare: Elevations in liver enzymes.
Danish: Sjældne: Stigning i leverenzymer.
English: Nateglinide should be used with caution in patients with moderate hepatic impairment.
Danish: Nedsat leverfunktion Nateglinid bør anvendes med forsigtighed til patienter med moderat nedsat leverfunktion.
English: The maximum recommended dose is 180 mg three times daily, taken before each of the three main meals.
Danish: Den maksimale anbefalede dosis er 180 mg tre gange daglig, taget før hvert af de tre hovedmåltider.
English: • Rare (may affect up to 1 in 1,000 people): mild abnormalities in liver function tests, allergic
Danish: • Sjælden (kan forekomme hos op til 1 ud af 1.000 personer): let unormale prøvesvar ved leverfunktionsprøver, overfølsomhedsreaktioner (allergiske reaktioner) såsom udslæt og kløe
English: The systemic availability and half-life of nateglinide in diabetic patients with mild, moderate (creatinine clearance 31-50 ml/min) and severe (creatinine clearance 15-30 ml/min) renal impairment (not undergoing dialysis) did not differ to a clinically significant degree from those in healthy subjects.
Danish: Der var ingen klinisk signifikant forskel mellem nateglinids systemiske tilgængelighed og halveringstid hos diabetikere med let, moderat (kreatininclearance 31-50 ml/min) og svært (kreatininclearance 15-30 ml/min) nedsat nyrefunktion (ikke i dialyse) og hos raske personer.
English: - Monoamine oxidase inhibitors (used to treat depression).
Danish: - Monoaminooxidase-hæmmere (bruges til at behandle depression).
English: It is best to take it right before a main meal but you can take it up to 30 minutes before.
Danish: Det er bedst at tage Starlix umiddelbart før et hovedmåltid, men det kan tages inden for 30 minutter, før et måltid påbegyndes.
English: Check with your doctor, pharmacist or nurse if you are not sure.
Danish: Spørg lægen, apotekspersonalet eller sundhedspersonalet, hvis der er noget du er i tvivl om.
English: Excipient with known effect Lactose monohydrate: 141.5 mg per tablet.
Danish: Hjælpestof, som behandleren skal være opmærksom på Lactosemonohydrat: 141,5 mg per tablet.
English: Discontinuation should be considered in patients with severe renal impairment who present with potentiation of the hypoglycaemic effect.
Danish: Det bør overvejes at seponere behandlingen hos patienter med svært nedsat nyrefunktion, hvor øgning af den hypoglykæmiske effekt er til stede.
English: Each film-coated tablet contains 60 mg nateglinide.
Danish: Hver filmovertrukket tablet indeholder 60 mg nateglinid.
English: Therefore, dose discontinuation is advisable in patients with severe renal impairment who present with potentiation of hypoglycaemic effect while on Starlix.
Danish: Derfor tilrådes dosisafbrydelse hos patienter med svært nedsat nyrefunktion, hvor øgning af den hypoglykæmiske effekt er til stede under behandling med Stalix.
English: These symptoms include excessive thirst, frequent urination, weakness, fatigue, nausea, shortness of breath or confusion.
Danish: Disse symptomer omfatter stor tørst, hyppig vandladning, svaghed, træthed,
English: Excipient with known effect Lactose monohydrate: 283 mg per tablet.
Danish: Hjælpestof, som behandleren skal være opmærksom på Lactosemonohydrat: 283 mg per tablet.
English: Excipient with known effect Lactose monohydrate: 214 mg per tablet.
Danish: Hjælpestof, som behandleren skal være opmærksom på Lactosemonohydrat: 214 mg per tablet.
English: If you have accidentally taken too many tablets, or if someone else takes your tablets, talk to a doctor or pharmacist immediately.
Danish: Søg straks din læge eller apotekspersonalet, hvis du kommer til at tage for mange tabletter, eller hvis en anden tager dine tabletter.
English: The recommended maximum daily dose is 180 mg three times daily to be taken before the three main meals.
Danish: Den anbefalede maksimale daglige dosis er 180 mg tre gange daglig indtaget før hvert af de tre hovedmåltider.