FrancophonIA/ELRC3.0 huggingface dataset:
English: Ceplene maintenance therapy should be administered following completion of consolidation therapy in patients concomitantly treated with IL-2 under the supervision of a physician experienced in the management of acute myeloid leukaemia.
Slovenian: Vzdrževalno zdravljenje z zdravilom Ceplene je namenjeno uporabi po zaključku utrditvene terapije pri bolnikih, sočasno zdravljenih z IL-2 pod nadzorom zdravnika z izkušnjami na področju zdravljenja akutne mieloične levkemije.
English: If you accidentally inject more than you were told to, contact your doctor or pharmacist immediately.
Slovenian: Če ste si po nesreči injicirali večji odmerek zdravila, kot bi smeli, se nemudoma obrnite na zdravnika ali farmacevta.
English: The role of IL-2 is to promote the functions of NK cells and T cells by activating the anti-leukaemic properties of these cells and by expanding these cell populations by inducing cell cycle proliferation.
Slovenian: IL-2 spodbuja delovanje celic ubijalk (NK) in T celic tako, da aktivira njihove protilevkemične lastnosti, z induciranjem proliferacije celic pa vpliva tudi na povečevanje populacije teh celic.
English: Although the degree of renal impairment has no demonstrable effect on the pharmacokinetic disposition of Ceplene, caution is warranted when Ceplene is administered to patients with severe renal impairment.
Slovenian: Čeprav stopnja ledvične okvare nima nobenih očitnih učinkov na farmakokinetiko zdravila Ceplene, je pri predpisovanju zdravila bolnikom s hudo ledvično okvaro potrebna previdnost.
English: Ceplene/IL-2 is an immunotherapy which aims to induce immune-mediated destruction of residual myeloid leukaemic cells and thereby to prevent relapse of leukaemia.
Slovenian: Zdravljenje z zdravilom Ceplene in IL-2 je imunoterapija, katere namen je inducirati imunsko uničevanje preostalih mieloičnih levkemičnih celic in tako preprečiti relaps levkemije.
English: IL-2 is injected twice daily as a subcutaneous injection (in the layer of tissue just under the skin) 1 to 3 minutes before the injection of Ceplene.
Slovenian: IL-2 se injicira dvakrat na dan v obliki subkutane injekcije (v plast tkiva neposredno pod kožo), 1 do 3 minute pred injiciranjem zdravila Ceplene.
English: • If you have further questions, please ask your doctor, pharmacist or nurse.
Slovenian: • Če imate dodatna vprašanja, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: • Abnormal redness of the skin (erythema), increased sweating (hyperhidrosis), night sweats and itching (pruritus)
Slovenian: • nenormalna pordelost kože (eritem), povečano potenje (hiperhidroza), nočno potenje in srbenje
English: Always vary the site that you inject.
Slovenian: Vedno menjajte mesto injiciranja.
English: No clinical data are available on the effects of Ceplene on fertility.
Slovenian: O vplivu zdravila Ceplene na plodnost ni na voljo kliničnih podatkov.
English: Common side effects (may affect up to 1 in 10 people)
Slovenian: Pogosti neželeni učinki (pojavijo se lahko pri 1 od 10 bolnikov)
English: Skin and subcutaneous tissue disorders dry skin
Slovenian: Bolezni kože in podkožja suha koža zelo pogosti
English: Dispensing of dilute IL-2 (aldesleukin) for each patient
Slovenian: Odmerjanje razredčenega IL-2 (aldeslevkin) za posameznega bolnika
English: Studies have shown chemical stability and sterility of diluted aldesleukin (dispensed in capped polypropylene tuberculin syringes) for up to three weeks when prepared in a controlled aseptic environment and stored under refrigeration at 2°C - 8°C.
Slovenian: Kemična stabilnost in sterilnost razredčenega aldeslevkina (odmerjenega v polipropilenske tuberkulinske brizge z zamaškom) sta bili v študijah dokazani za tri tedne, če je bilo redčenje opravljeno v kontroliranih, aseptičnih pogojih in aldeslevkin shranjen v hladilniku pri temperaturi 2°C - 8°C.
English: • Cough, difficulty in breathing (dyspnoea)
Slovenian: • kašljanje, težave pri dihanju (dispneja)
English: Study AML-1 was exploratory, enrolling 39 AML patients in remission to determine the dose and feasibility of Ceplene administered together with IL-2.
Slovenian: V študijo AML-1, ki je bila raziskovalna, je bilo vključenih 39 bolnikov z akutno mieloično levkemijo v remisiji za določitev odmerka in možnosti sočasne uporabe zdravila Ceplene in IL-2.
English: w.31
Slovenian: t. 31
English: Treatment can be resumed by administering Ceplene at the full dose and IL-2 at 50%.
Slovenian: Zdravljenje lahko nadaljujete z dajanjem polnega odmerka zdravila Ceplene in 50 % odmerka IL-2.
English: • Hives, bruising, rash and swelling at the injection site, weakness (asthenia) and chest pain
Slovenian: • koprivnica, modrice, izpuščaji in otekline na mestu injiciranja, oslabelost (astenija) in bolečine v prsih
English: w.7 to w.9 (Days 1-21)
Slovenian: t. 7 do t. 9 (dnevi 1-21)
English: Sodium hydroxide (for pH adjustment) Hydrochloric acid (for pH adjustment) Water for injections
Slovenian: 6.1 Seznam pomožnih snovi natrijev klorid natrijev hidroksid (za uravnavanje pH) klorovodikova kislina (za uravnavanje pH) voda za injekcije
English: H1 receptor blocking antihistamines or neuroleptics (anti-psychotics) with H1 receptor blocking properties that might decrease efficacy of Ceplene should be avoided.
Slovenian: Antihistaminiki iz skupine antagonistov receptorjev H1 ali nevroleptiki (antipsihotiki) z antagonističnim delovanjem na receptorje H1 lahko zmanjšajo učinkovitost zdravila Ceplene in se jim je zato treba izogibati.
English: • Beta-blockers, such as propranolol, metoprolol, atenolol.
Slovenian: • Antagonisti adrenergičnih receptorjev beta, kot so propranolol, metoprolol, atenolol.
English: By inhibiting oxidase function and reducing ROS production, Ceplene protects IL-2-activated NK cells and T cells from oxygen free radical-induced inhibition and apoptosis.
Slovenian: S preprečevanjem oksidaze in zmanjševanjem nastajanja kisikovih reaktivnih vrst, zdravilo Ceplene varuje z IL-2 aktivirane celice ubijalke (NK) in T celice, pred inhibicijo in apoptozo zaradi kisikovih prostih radikalov.
English: If you are taking any of the following medicines, please be sure to discuss this with your doctor or pharmacist before using Ceplene.
Slovenian: Če jemljete katero koli od spodaj navedenih zdravil, se pred uporabo zdravila Ceplene o tem pogovorite s svojim zdravnikom ali farmacevtom.
English: Withdraw and discard the syringe as instructed.
Slovenian: Iglo potegnite ven in brizgo odstranite v skladu z navodili.
English: They are used to treat stomach ulcers, indigestion (dyspepsia) or heartburn (see above “Do not use Ceplene”).
Slovenian: Uporabljajo se za zdravljenje želodčnih razjed, slabe prebave (dispepsije) ali zgage (glejte poglavje zgoraj „Ne uporabljajte zdravila Ceplene“).
English: Although the degree of renal impairment has little effect on the PK disposition of histamine, caution should be used in the administration of histamine to patients with severe renal impairment.
Slovenian: Čeprav stopnja ledvične okvare le malo vpliva na farmakokinetične lastnosti histamina, je pri predpisovanju histamina bolnikom s hudo ledvično okvaro potrebna previdnost.
English: • Increase in the number of a certain type of white blood cells in the blood (eosinophilia) and decrease in the number of blood platelets (thrombocytopenia)
Slovenian: • povečano število določenih belih krvnih celic v krvi (eozinofilija) in upad števila trombocitov
English: PREPARATION FOR INJECTION OF CEPLENE
Slovenian: PRIPRAVA ZA INJICIRANJE ZDRAVILA CEPLENE
English: Ceplene inhibits NAPDH oxidase which initiates the formation and release of ROS from phagocytes.
Slovenian: Zdravilo Ceplene zavira NAPDH oksidazo, ki sproži nastanek in sproščanje kisikovih reaktivnih vrst (ROS) iz fagocitov.
English: You will have to inject Ceplene and IL-2 twice a day by subcutaneous injection (in the layer of tissue just under the skin), according to the directions provided by your doctor.
Slovenian: Zdravilo Ceplene in IL-2 si morate injicirati dvakrat na dan s subkutanim injiciranjem (v plast tkiva neposredno pod kožo) v skladu z navodili zdravnika.
English: Animal studies revealed no adverse effects on fertility apart from a slight reduction in implantations and viable foetuses (see section 5.3).
Slovenian: Študije na živalih niso pokazale vpliva na sposobnost razmnoževanja, razen nekoliko slabše možnosti vsaditve in števila za preživetje sposobnih zarodkov (glejte poglavje 5.3).
English: Ceplene is a clear, colourless liquid.
Slovenian: Zdravilo Ceplene je prozorna, brezbarvna tekočina.
English: Endocrine disorders hypothyroidism
Slovenian: Bolezni endokrinega sistema hipotiroidizem pogosti
English: The two medicines, IL-2 and Ceplene, are both injected twice a day, with a minimum of 6 hours between injections.
Slovenian: Oba, IL-2 in zdravilo Ceplene se injicirata dvakrat na dan, med injiciranjema pa naj preteče vsaj 6 ur.
English: Thus, subjects with severe renal impairment may be more sensitive to the blood pressure lowering effects of exogenously administered histamine than subjects with normal renal function or subjects with mild or moderate renal impairment.
Slovenian: To pomeni, da so preiskovanci s hudo ledvično okvaro morda bolj občutljivi na vplive eksogeno vnešenega histamina na zniževanja krvnega tlaka kot preiskovanci z normalnim delovanjem ledvic ali preiskovanci z blago ali zmerno ledvično okvaro.
English: If bubbles appear in the syringe, push the solution slowly back into the vial and withdraw the solution again.
Slovenian: Če se v brizgi pojavijo mehurčki, raztopino ponovno iztisnite iz brizge nazaj v vialo in nato ponovno napolnite brizgo.
English: - IL-2 can be discontinued for 24 hours and then restarted at a 20% dose reduction level.
Slovenian: Povišana telesna temperatura - zdravljenje z IL-2 prekinite za 24 ur, nato pa ponovno pričnite z 20-odstotno zmanjšanim odmerkom.
English: 6.6 Special precaution for disposal and other handling
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom
English: Gastrointestinal disorders nausea, dyspepsia, diarrhoea Very common vomiting, abdominal pain upper, dry mouth, gastritis, abdominal distention
Slovenian: Bolezni prebavil navzea, dispepsija, diareja zelo pogosti bruhanje, bolečine v zgornjem delu trebuha, suha usta, gastritis, trebušna distenzija pogosti
English: The preferred injection areas are the thighs and the abdomen.
Slovenian: Priporočeno mesto injiciranja so stegna in trebuh.
English: w.28
Slovenian: t. 28
English: The concomitant administration of Ceplene and IL-2 therefore aims to optimise the anti-leukaemic functions of NK cells and T cells.
Slovenian: Sočasna uporaba zdravila Ceplene in IL-2 tako teži k optimizaciji protilevkemičnega delovanja celic ubijalk (NK) in T celic.
English: There is no information about the use of Ceplene in pregnant women.
Slovenian: Ni kliničnih podatkov o uporabi zdravila Ceplene pri nosečnicah.
English: You must be monitored to check how you respond to treatment.
Slovenian: Ob začetku zdravljenja je potreben nadzor vašega odzivanja na zdravilo.
English: to w.66
Slovenian: do t. 66
English: • Tricyclic antidepressant medicines such as amitryptiline, imipramine, or monoamine oxidase inhibitors, such as phenelzine, isocarboxazide, tranylcypromine or moclobemide.
Slovenian: • Triciklični antidepresivi, kot so amitriptilin, imipramin ali zaviralci monoaminooksidaze, kot so fenelzin, izokarboksazid, tranilcipromin ali moklobemid.
English: Metabolism and nutrition disorders anorexia
Slovenian: Presnovne in prehranske motnje anoreksija pogosti
English: A maximum delay of one treatment cycle can be considered for the resolution of grade 3 and 4 events.
Slovenian: Za razrešitev dogodkov 3. in 4. stopnje toksičnosti lahko preučite možnost odložitve največ enega cikla zdravljenja.
English: Also, if you are to have an operation or special X-ray investigation requiring an injection, first make sure that your doctor knows that you are receiving Ceplene.
Slovenian: Če boste v kratkem operirani ali boste imeli rentgensko preiskavo na način, ki zahteva injiciranje, o jemanju zdravila Ceplene predhodno obvestite lečečega zdravnika.
English: Ceplene 0.5 mg/0.5 mL solution for injection
Slovenian: Ceplene 0,5 mg/0,5 mL raztopina za injiciranje
English: It is recommended that you always have someone with you when injecting this medicine, such as an adult family member, friend or other care provider who could help you if you feel light-headed or faint.
Slovenian: Priporoča se, da je pri samoinjiciranju zdravila vedno nekdo prisoten, na primer odrasel družinski član, prijatelj ali drug skrbnik, ki vam lahko pomaga v primeru omotičnosti ali omedlevice.
English: System organ class
Slovenian: Organski sistemi
English: to w.54
Slovenian: do t. 54
English: to w.75
Slovenian: do t. 75
English: INSTRUCTIONS FOR SELF-INJECTION OF CEPLENE
Slovenian: NAVODILA ZA SAMOINJICIRANJE ZDRAVILA CEPLENE
English: Monoamine oxidase inhibitors, anti-malarial, and anti-trypanosomal active substances may alter the metabolism of Ceplene and should be avoided (see section 4.4).
Slovenian: Zaviralci monoaminooksidaze, antimalariki in zdravila za zdravljenje tripanosomoze lahko spremenijo presnovo zdravila Ceplene in se jim je zato treba izogibati (glejte poglavje 4.4).
English: • Tingling, prickling or numbness of the skin (paraesthesia)
Slovenian: • zbadanje, mravljinci ali odrevenelost kože (parestezija)
English: Obtain new supplies and start the procedure over again, even if 3 minutes have passed after injection of IL-2.
Slovenian: Postopek ponovite z novo brizgo z zdravilom Ceplene, čeprav so 3 minute po injiciranju IL-2 že potekle.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of repeated-dose toxicity, local tolerance and genotoxicity.
Slovenian: Predklinični podatki na osnovi običajnih študij toksičnosti pri ponavljajočih odmerkih, lokalnega prenašanja in genotoksičnosti ne kažejo posebnega tveganja za za človeka.
English: • Steroids such as prednisone and dexamethasone.
Slovenian: • Steroidi, kot sta prednizon in deksametazon.
English: Replace the cover on the needle.
Slovenian: Na iglo ponovno namestite pokrovček.
English: Date of first authorisation: Date of latest renewal:
Slovenian: Datum prve odobritve: Datum zadnjega podaljšanja: 26/08/2013
English: • Decrease in the number of white blood cells (leucopenia)
Slovenian: • znižanje števila belih krvničk (levkopenija)
English: While posology differs, when Ceplene is used in conjunction with IL-2, physicians should also refer to the Summary of Product Characteristics (SmPC) for IL-2 and observe the respective medicinal product interactions.
Slovenian: Odmerjanje se ob sočasni uporabi zdravila Ceplene in IL-2 sicer razlikuje, kljub temu pa naj zdravniki upoštevajo tudi povzetek glavnih značilnosti zdravila z IL-2 in interakcije zanj.
English: Ceplene has moderate influence on the ability to drive and use machines.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja strojev Zdravilo Ceplene ima zmeren vpliv na sposobnost vožnje in upravljanja strojev.
English: Place the syringe on a clean flat surface.
Slovenian: Brizgo položite na čisto ravno površino.
English: to w.21
Slovenian: do t. 21
English: There are no significant effects of age or weight on the pharmacokinetic properties of histamine.
Slovenian: Na farmakokinetične lastnosti histamina starost ali telesna masa nimata bistvenega vpliva.
English: However, no Ceplene dose reduction is normally required in renally impaired patients.
Slovenian: Kljub temu pa pri bolnikih z ledvično okvaro ponavadi ni treba zmanjševati odmerkov.
English: No altered dose recommendations with the exception of grade 1 neurologic toxicity and grade 1 generalised toxic dermatitis.
Slovenian: Za bolnike, pri katerih se pojavlja 1. stopnja toksičnih dogodkov Z izjemo 1. stopnje nevrološke toksičnosti in 1. stopnje generaliziranega toksičnega dermatitisa se prilagajanja odmerkov ne priporoča.
English: For instructions on the initial reconstitution and subsequent dilution to 200 µg/mL of Interleukin-2 (aldesleukin) before administration, see commercially available IL-2 SmPC.
Slovenian: Za navodila za začetno rekonstitucijo in nadaljnje redčenje do 200 µg/ml interlevkina-2 (aldeslevkina) pred dajanjem glejte komercialno dostopen povzetek glavnih značilnosti zdravila [SmPC] za IL-2.
English: If you have liver problems, talk to your doctor before using this medicine.
Slovenian: Če imate težave z ledvicami, se pred začetkom uporabe tega zdravila o tem pogovorite z zdravnikom.
English: For cycles 1-3, each cycle consists of 3 weeks of treatment, followed by a 3-week treatment free period.
Slovenian: Cikli 1-3 so sestavljeni iz 3 tednov zdravljenja, čemur sledi 3 tedensko obdobje brez zdravljenja.
English: For cycles 4-10, each cycle consists of 3 weeks of treatment, followed by a 6-week treatment free period.
Slovenian: Cikli 4-10 so sestavljeni iz 3 tednov zdravljenja, čemur sledi 6 tedensko obdobje brez zdravljenja.
English: Blood and lymphatic system disorders eosinophilia, thrombocytopenia Very common leucopenia, neutropenia
Slovenian: Bolezni krvi in limfatičnega sistema eozinofilija, trombocitopenija zelo pogosti levkopenija, nevtropenija pogosti
English: Ceplene is administered 1 to 3 minutes after each injection of IL-2.
Slovenian: Zdravilo Ceplene se daje 1 do 3 minute po vsaki injekciji IL-2.
English: • Decrease in the number of a certain type of white blood cells (neutropenia)
Slovenian: • znižanje števila določene vrste belih krvničk (nevtropenija)
English: • Patients receiving systemic steroid therapy, clonidine and H2 blocking agents.
Slovenian: • Bolniki, zdravljeni s sistemskimi steroidi, klonidinom ali antagonisti histaminskih receptorjev
English: -for grade 2 toxicity, the IL-2 dose should be reduced 50% and only increased to full dose if the symptoms do not reappear.
Slovenian: Nato z zdravljenjem nadaljujte z nespremenjenim odmerkom zdravila Ceplene, odmerek IL-2 pa zmanjšajte za 20 odstotkov; - pri 2. stopnji toksičnosti odmerek IL-2 zmanjšajte za 50 % in ponovno povečajte na poln odmerek le v primeru, če se simptomi ne pojavijo ponovno.
English: Plasma Ceplene levels are higher in patients with moderate and severe liver impairment, and these patient groups tend to experience more tachycardia and lower blood pressure after Ceplene dosing than do patients with normal or mildly affected liver function.
Slovenian: pri teh skupinah bolnikov pa je tudi večja verjetnost pojava tahikardije in nižjega krvnega tlaka po aplikaciji zdravila Ceplene kot pri bolnikih z normalnim ali le nekoliko slabšim delovanjem jeter.
English: w.49
Slovenian: t. 49
English: It is recommended that you always have someone with you when injecting Ceplene, such as an adult family member, friend, or other care provider to help you if you feel light-headed or faint.
Slovenian: Priporočamo, da je pri samoinjiciranju zdravila Ceplene vedno nekdo prisoten, na primer odrasel družinski član, prijatelj ali drug skrbnik, ki vam lahko pomaga v primeru omedlevice ali vrtoglavice.
English: to w.39
Slovenian: do t. 39
English: Figure 1
Slovenian: Slika 1
English: Ceplene must be injected 1 to 3 minutes after IL-2.
Slovenian: Zdravilo Ceplene se injicira 1 do 3 minute po injiciranju IL-2.
English: Figure 5
Slovenian: Slika 5
English: For patients experiencing grade 2 (including cardiac function, renal, hepatic) toxicity - treatment should be discontinued until the event has returned to grade 1 - the time of injection of the dose of Ceplene should be extended to a maximum of 15 minutes.
Slovenian: Za bolnike, pri katerih se pojavlja 2. stopnja toksičnosti (vključno s srčno, ledvično, jetrno toksičnostjo) - zdravljenje je treba prekiniti, dokler se dogodki ne povrnejo na 1. stopnjo, - čas injiciranja odmerka zdravila Ceplene podaljšajte na največ 15 minut, - pri srčni, jetrni ali ledvični toksičnosti odmerka tako zdravila Ceplene kot IL-2 zmanjšajte za 20 %.
English: to w.72
Slovenian: do t. 72
English: w.76
Slovenian: t. 76
English: w.46
Slovenian: t. 46
English: w.64
Slovenian: t. 64
English: Pull the needle cover straight off. With the vial standing on a flat surface, insert the needle straight through the rubber stopper into the vial.
Slovenian: Viala naj stoji na ravni podlagi in vanjo naravnost skozi gumijasto zaporko vstavite iglo.
English: Treatment with Ceplene in conjunction with IL-2 should be used with caution in patients with poorly compensated cardiac function.
Slovenian: Previdnost je potrebna pri sočasnem zdravljenju z zdravilom Ceplene in IL-2 pri bolnikih s slabšim delovanjem srca.
English: Infections and infestations upper respiratory tract infections
Slovenian: Infekcijske in parazitske bolezni okužbe zgornjih dihal zelo pogosti pljučnica pogosti
English: Dose reduction of Ceplene is normally not required in hepatically impaired patients, but caution should be used in these patients.
Slovenian: Pri bolnikih z jetrno okvaro ponavadi ni treba zmanjšati odmerka zdravila Ceplene, kljub temu pa se priporoča previdnost.
English: to w.30
Slovenian: do t. 30
English: Pinch up a section of the cleaned skin between your thumb and forefinger, without squeezing it. See Figure 5.
Slovenian: S palcem in kazalcem primite kožo na očiščenem mestu, vendar je pri tem ne stiskajte.
English: to w.63
Slovenian: do t. 63
English: • If you get any side effects, talk to your doctor or pharmacist.
Slovenian: • Če opazite kateri koli neželeni učinek, se posvetujte z zdravnikom ali farmacevtom.
English: • During breast feeding.
Slovenian: • Med dojenjem.
English: Investigations weight decreased
Slovenian: Preiskave zmanjšanje telesne mase pogosti
English: • Vomiting, pain in the upper belly (abdominal pain) and dry mouth
Slovenian: • bruhanje, bolečine v zgornjem delu trebuha in suha usta
English: See Figure 1.
Slovenian: Glejte sliko 1.
English: Figure 2
Slovenian: Slika 2
English: If you have missed one of your doses in a day, contact your doctor or pharmacist.
Slovenian: Če ste pozabili vzeti enega od dnevnih odmerkov, se obrnite na zdravnika ali farmacevta.
English: w.73
Slovenian: t. 73
English: w.67
Slovenian: t. 67
English: What Ceplene contains
Slovenian: Kaj vsebuje zdravilo Ceplene
English: Dispensing instructions for IL-2 (aldesleukin)
Slovenian: Navodila za odmerjanje IL-2 (aldeslevkin)
English: For persistent hypotension, headache, arrhythmia, cardiac, hepatic and renal toxicities - the time of injection of the dose of Ceplene should be extended to a maximum of 15 minutes.
Slovenian: Pri trdovratni hipotenziji, glavobolu, aritmiji, srčni, jetrni in ledvični toksičnosti - čas injiciranja odmerka zdravila Ceplene podaljšajte na največ 15 minut; - količini odmerkov tako zdravila Ceplene kot IL-2 zmanjšajte za 20 %.
English: It is provided in a glass vial with a grey rubber stopper and a blue peel flip off aluminium tamper evident over seal.
Slovenian: Zdravilo Ceplene je v stekleni viali s sivim gumijastim zamaškom in modro odstranljivo aluminijasto zaščitno zaporko.
English: See Figure 6.
Slovenian: Glejte sliko 6.
English: to w.27
Slovenian: do t. 27
English: Ceplene and IL-2 must not be injected into the same region.
Slovenian: Zdravila Ceplene in IL-2 ne smete injicirati na isto mesto.
English: The twice daily dosing of IL-2 and Ceplene should be separated by a minimum of 6 hours.
Slovenian: Med dvema dnevnima dajanjema IL-2 in zdravila Ceplene naj preteče vsaj 6 ur.
English: See Figure 7.
Slovenian: Glejte sliko 7.
English: w.37
Slovenian: t. 37
English: General disorders and administration site conditions injection site granuloma, fatigue, pyrexia, injection site erythema, feeling hot, injection site reaction, injection site pruritus, influenza like illness, chills, injection site inflammation, injection site pain
Slovenian: Splošne težave in spremembe na mestu aplikacije granulom na mestu injiciranja, utrujenost, povišana telesna temperatura, eritem na mestu injiciranja, občutek vročice, reakcija na mestu injiciranja, pruritus na mestu injiciranja, gripi podobna bolezen, mrzlica, vnetje na mestu injiciranja, bolečina na mestu injiciranja zelo pogosti koprivnica na mestu injiciranja, modrica na mestu injiciranja, izpuščaj na mestu injiciranja, oteklost na mestu injiciranja, astenija, bolečina v prsnem košu pogosti