FrancophonIA/ELRC3.0 huggingface dataset:
English: REYATAZ oral powder contains aspartame as a sweetening agent.
Danish: REYATAZ oralt pulver indeholder sødestoffet aspartam.
English: [95% CI]
Danish: [95% KI]d
English: Difference estimatee [95% CI]
Danish: Afvigelsesestimate [95% KI]
English: The efficacy of REYATAZ/ritonavir in combination with tenofovir disoproxil fumarate in treatmentexperienced patients has been demonstrated in clinical study 045 and in treatment naive patients in clinical study 138 (see sections 4.8 and 5.1).
Danish: Der er vist effekt af REYATAZ/ritonavir i kombination med tenofovirdisoproxilfumarat hos behandlingserfarne patienter i det kliniske studie 045 og hos behandlingsnaive patienter i det kliniske studie 138 (se pkt.
English: Do not take REYATAZ if you are allergic to atazanavir or any of the other ingredients of this medicine (listed in section 6) if you have moderate to severe liver problems.
Danish: Tag ikke REYATAZ: hvis du er allergisk over for atazanavir eller et af de øvrige indholdsstoffer i REYATAZ (angivet i afsnit 6).
English: For the recommended paediatric dosage, REYATAZ oral powder contains 3915.45 mg sucrose per 150 mg atazanavir, 5220.60 mg sucrose per 200 mg atazanavir, 6525.75 mg sucrose per 250 mg atazanavir, and 7830.90 mg sucrose per 300 mg atazanavir.
Danish: Den anbefalede pædiatriske dosis REYATAZ oralt pulver indeholder 3915,45 mg saccharose pr. 150 mg atazanavir, 5220,60 mg saccharose pr. 200 mg atazanavir, 6525,75 mg saccharose pr. 250 mg atazanavir og 7830,90 mg saccharose pr. 300 mg atazanavir.
English: LIST OF EXCIPIENTS Excipients: contains lactose (see leaflet for further information).
Danish: Hjælpestoffer: indeholder lactose (se indlægsseddel for yderligere information) 4.
English: Eleven subjects (13%) in the unboosted REYATAZ group and 6 (7%) in the REYATAZ + ritonavir group, had virologic rebound.
Danish: 11 forsøgspersoner (13%) i gruppen med ikke-boostet REYATAZ og 6 forsøgspersoner (7%) i gruppen med REYATAZ + ritonavir oplevede virologisk rebound.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Danish: Autoimmune lidelser (såsom Graves sygdom og autoimmun hepatitis) er også set; tiden til udbrud er imidlertid mere variabel, og udbrud kan optræde mange måneder efter behandlingsstart (se pkt.
English: Other marked clinical laboratory abnormalities (Grade 3 or 4) reported in ≥ 2% of patients receiving regimens containing REYATAZ and one or more NRTIs included: elevated creatine kinase (7%), elevated alanine aminotransferase/serum glutamic-pyruvic transaminase (ALT/SGPT) (5%), low neutrophils (5%), elevated aspartate aminotransferase/serum glutamic-oxaloacetic transaminase (AST/SGOT) (3%), and elevated lipase (3%).
Danish: Andre markante, kliniske laboratoriemæssige abnormaliteter (grad 3 eller 4) rapporteret hos ≥2% af patienterne, der fik regimer indeholdende REYATAZ og én eller flere NRTIer omfattede: forhøjet kreatinkinase (7%), forhøjet alaninaminotransferase/serum-glutamin-pyrudrue transaminase (ALAT/SGPT) (5%), lav neutrofiltælling (5%), forhøjet aspartataminotransferase/serum-glutaminoxalsyretransaminase (ASAT/SGOT) (3%) og forhøjet lipase (3%).
English: Week 48: 1.7% [-3.8%, 7.1%] Week 96: 6.1% [0.3%, 12.0%]
Danish: Uge 48: 1,7% [-3,8%, 7,1%] Uge 96: 6,1% [0,3%, 12,0%]
English: The choice of REYATAZ in treatment experienced adult and paediatric patients should be based on individual viral resistance testing and the patient's treatment history (see sections 4.4 and 5.1).
Danish: Valg af REYATAZ til behandlingserfarne voksne og pædiatriske patienter bør baseres på en individuel, viral resistenstest og patientens behandlingsanamnese (se pkt.
English: Two percent of patients treated with REYATAZ experienced concurrent Grade 3-4 ALT/AST and Grade 3-4 total bilirubin elevations.
Danish: To procent af patienterne behandlet med REYATAZ oplevede samtidig grad 3-4 ALAT/ASAT og grad 3-4 forhøjelser af total bilirubin.
English: REYATAZ should be administered 2 hours before or 1 hour after antacids or buffered medicinal products.
Danish: REYATAZ bør administreres 2 timer før eller 1 time efter antacida eller lægemidler med buffer.
English: Instructions for REYATAZ oral powder:
Danish: Vejledning for REYATAZ oralt pulver:
English: It is not recommended to use REYATAZ with ritonavir for pregnant patients who are receiving both tenofovir disoproxil and an H2-receptor antagonist.
Danish: REYATAZ med ritonavir anbefales ikke til gravide, der både anvender tenofovirdisoproxil og en H2-receptorantagonist.
English: AUC ng•h/mL
Danish: AUC ng•time/ml
English: b See description of selected adverse reactions for more details.
Danish: b Se Beskrivelse af udvalgte bivirkninger.
English: ≥ 200 cells/mm3
Danish: ≥ 200 celler/mm3
English: Co-administration of REYATAZ with ritonavir at doses greater than 100 mg once daily has not been clinically evaluated.
Danish: Samtidig administration af REYATAZ og ritonavir i doser over 100 mg én gang dagligt er ikke evalueret klinisk.
English: Hepatic impairment: atazanavir is metabolised and eliminated primarily by the liver.
Danish: Nedsat leverfunktion: Atazanavir metaboliseres og udskilles primært via leveren.
English: Protease inhibitor resistance was defined as genotypic resistance to atazanavir or either component of the local NRTI backbone based on the criteria of 1) any major mutations: I50L, I84V, N88S and 2) ≥ 2 of the following minor or cross resistant mutations: M46I/L, G48V, I54L/V/M/T/A, V82A/T/FI, L90M, V32I.
Danish: Proteasehæmmerresistens blev defineret som genotypisk resistens over for atazanavir eller de enkelte komponenter i den lokale NRTI-backbone baseret på kriterie 1) enhver type større mutationer: I50L, I84V, N88S og 2) ≥ 2 af følgende mindre eller krydsresistente mutationer: M46I/L, G48V, I54L/V/M/T/A, V82A/T/FI, L90M, V32I.
English: Protease inhibitors: The co-administration of REYATAZ/ritonavir and other protease inhibitors has not been studied but would be expected to increase exposure to other protease inhibitors.
Danish: Proteasehæmmere: Samtidig administration af REYATAZ/ritonavir og andre proteasehæmmere er ikke undersøgt, men forventes at øge eksponeringen for andre proteasehæmmere.
English: The decrease in AUC, Cmax, and Cmin was not mitigated when an increased dose of REYATAZ/ritonavir (400/100 mg once daily) was temporally separated from omeprazole by 12 hours.
Danish: Faldet i AUC, Cmax, and Cmin var ikke mindre, når en øget dosis af REYATAZ/ritonavir (400/100 mg én gang dagligt) blev forskudt fra omeprazol med 12 timer.
English: REYATAZ 100 mg hard capsules REYATAZ 150 mg hard capsules REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules
Danish: REYATAZ 100 mg hårde kapsler REYATAZ 150 mg hårde kapsler REYATAZ 200 mg hårde kapsler REYATAZ 300 mg hårde kapsler
English: grazoprevir-containing products, including elbasvir/grazoprevir fixed dose combination, and glecaprevir/pibrentasvir fixed dose combination (used to treat chronic hepatitis C infection)
Danish: produkter indeholdende grazoprevir, inklusive elbasvir/grazoprevir i fastdosis-kombination, og glecaprevir/pibrentasvir i fastdosis-kombination (bruges til behandling af kronisk hepatitis C infektion)
English: a Number of patients with paired genotypes classified as virological failures (HIV RNA ≥ 400 copies/ml).
Danish: a Antal patienter med parvise genotyper, der er klassificeret som virologisk svigt (hiv-RNA ≥ 400 kopier/ml).
English: The REYATAZ/ritonavir arm showed similar (non-inferior) antiviral efficacy compared to the lopinavir/ritonavir arm, as assessed by the proportion of patients with HIV RNA < 50 copies/ml at week 48 (Table 5).
Danish: REYATAZ/ritonavir-armen viste antiviral effekt svarende til lopinavir/ritonavir-armen (non-inferiør) vurderet ved andelen af patienter med hiv-RNA <50 kopier/ml ved uge 48 (tabel 5).
English: Each carton contains 30 sachets.
Danish: Hvert brev indeholder 30 breve.
English: Combinations of REYATAZ and indinavir have not been studied and co-administration of these medicinal products is not recommended (see section 4.5).
Danish: Kombinationer af REYATAZ og indinavir er ikke undersøgt, og samtidig administration af disse lægemidler kan ikke anbefales (se pkt.
English: In clinical studies, REYATAZ (with or without ritonavir) has been shown to induce dyslipidaemia to a lesser extent than comparators.
Danish: REYATAZ har i kliniske studier (med eller uden ritonavir) vist sig at inducere dyslipidæmi i mindre udstrækning end andre sammenlignelige produkter, der indgik i studierne.
English: In clinical trial AI424-182 REYATAZ/ritonavir (300/100 mg or 400/100 mg) in combination with zidovudine/lamivudine was administered to 41 pregnant women during the second or third trimester.
Danish: I det kliniske studie AI424-182 blev REYATAZ/ritonavir (300/100 mg eller 400/100 mg) administreret samtidig med zidovudin/lamivudin til 41 gravide kvinder i andet og tredje trimester.
English: Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levels.
Danish: Data vedrørende samtidig brug af parenteral midazolam og andre proteasehæmmere tyder på en mulig 34 gange stigning i midazolamplasmaniveauet.
English: It is important that you take REYATAZ with food (a meal or a substantial snack) as this helps the body absorb the medicine.
Danish: Brug af REYATAZ sammen med mad og drikke Det er vigtigt, at du tager REYATAZ sammen med mad (et måltid eller et større mellemmåltid), da dette hjælper kroppen med at optage medicinen.
English: The most frequently reported laboratory abnormality in patients receiving regimens containing REYATAZ and one or more NRTIs was elevated total bilirubin reported predominantly as elevated indirect [unconjugated] bilirubin (87% Grade 1, 2, 3, or 4).
Danish: Den oftest rapporterede laboratoriemæssige anormalitet hos patienter, der fik regimer indeholdende REYATAZ og én eller flere NRTIer, var forhøjet total bilirubin, primært indberettet som indirekte forhøjet [ukonjugeret] bilirubin (87% grad 1, 2, 3 eller 4).
English: Stop taking REYATAZ and talk to your doctor immediately if you develop a severe rash or a rash with flu-like illness symptoms, blisters, fever, mouth sores, muscle or joint pain, swelling in the face, inflammation of the eye which causes redness (conjunctivitis), painful, warm, or red lumps (nodules).
Danish: Stop straks med at tage REYATAZ og tal med lægen, hvis du får alvorligt udslæt eller udslæt med influenzalignende symptomer, blærer, feber, forkølelsessår, muskel- eller ledsmerter, hævelse i ansigtet, øjenbetændelse, som forårsager røde øjne (konjunktivitis), smertefulde, varme eller røde knuder.
English: Human experience of acute overdose with REYATAZ is limited.
Danish: Der er begrænset erfaring med akut human overdosering med REYATAZ.
English: Patients co-infected with hepatitis B and/or hepatitis C virus Among 1,151 patients receiving atazanavir 400 mg once daily, 177 patients were co-infected with chronic hepatitis B or C, and among 655 patients receiving atazanavir 300 mg once daily with ritonavir 100 mg once daily, 97 patients were co-infected with chronic hepatitis B or C. Co-infected patients were more likely to have baseline hepatic transaminase elevations than those without chronic viral hepatitis.
Danish: Blandt 1.151 patienter, der fik 400 mg atazanavir én gang dagligt, var 177 patienter samtidig inficeret med kronisk hepatitis B eller C, og blandt 655 patienter, der fik 300 mg atazanavir én gang dagligt med 100 mg ritonavir én gang dagligt, var 97 patienter samtidig inficeret med kronisk hepatitis B eller C. Samtidigt inficerede patienter havde større sandsynlighed for forhøjede levertransaminaser ved baseline end de, der ikke havde kronisk viral hepatitis.
English: - The other ingredients are crospovidone, lactose monohydrate, and magnesium stearate.
Danish: - - Øvrige indholdsstoffer: crospovidon, lactosemonohydrat og magnesiumstearat.
English: The M184V substitution in reverse transcriptase, which confers resistance to lamivudine and emtricitabine, was detected in 2 subjects in the unboosted REYATAZ and 1 subject in the REYATAZ + ritonavir group.
Danish: Der blev observeret M184V-substitution i revers transkriptase, som medfører resistens over for lamivudin og emtricitabin, hos 2 forsøgspersoner i gruppen med ikkeboostet REYATAZ og hos 1 forsøgsperson i REYATAZ + ritonavir-gruppen.
English: Treatment-Naive REYATAZ Powder/ritonavir n=52
Danish: Behandlingsnaiv REYATAZ pulver/ritonavir n=52
English: These are listed under Do not take REYATAZ, at the start of Section 2.
Danish: Disse lægemidler er nævnt i starten af afsnit 2 Brug ikke REYATAZ.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION REYATAZ 50 mg oral powder
Danish: LÆGEMIDLETS NAVN, STYRKE OG/ELLER ADMINISTRATIONSVEJ(E) REYATAZ 50 mg oralt pulver
English: REYATAZ (without ritonavir) has been studied in adult subjects with moderate-to-severe hepatic impairment (14 Child-Pugh Class B and 2 Child-Pugh Class C subjects) after a single 400 mg dose.
Danish: REYATAZ (uden ritonavir) er blevet undersøgt hos voksne forsøgspersoner med moderat til alvorligt nedsat leverfunktion (14 forsøgspersoner med Child-Pugh klasse B og 2 forsøgspersoner med Child-Pugh klasse C) efter en enkelt 400 mg dosis.
English: REYATAZ is also available in capsules for use in adults and children at least 6 years of age who weigh at least 15 kg and who are able to swallow the capsules.
Danish: REYATAZ fås også som kapsler til voksne og børn på mindst 6 år, som vejer mindst 15 kg og som er i stand til at sluge kapsler.
English: The withdrawal of ritonavir from the boosted regimen of REYATAZ is not recommended, but may be considered in adults patients at the dose of 400 mg once daily with food only under the following combined restrictive conditions:
Danish: Seponering af ritonavir fra det boostede REYATAZ-regime frarådes, men en dosis på 400 mg REYATAZ én gang dagligt sammen med føde kan overvejes hos voksne patienter under følgende kombinerede restriktive forhold:
English: It should be ensured that the patient eats or drinks all the infant formula, beverage or food that contains the powder.
Danish: Det bør sikres, at patienten spiser eller drikker al den pulverholdige modermælkserstatning, væske eller føde.
English: Excipient with known effect: 63 mg of aspartame; 1305.15 mg of sucrose per sachet (1.5 g oral powder).
Danish: Hjælpestof, som behandleren skal være opmærksom på: 63 mg aspartam; 1305,15 mg saccharose pr. brev (1,5 g oralt pulver).
English: Consult the dosing table for the specific formulation (see Summary of Product Characteristics for REYATAZ capsules).
Danish: Se doseringstabellen for den pågældende formulering (se produktresumeeet for REYATAZ kapsler).
English: Co-administration of atazanavir/ritonavir with boceprevir resulted in lower exposure of atazanavir which may be associated with lower efficacy and loss of HIV control.
Danish: Samtidig administration af atazanavir/ritonavir og boceprevir medførte lavere atazanavir-eksponering, hvilket kan resultere i lavere effekt og manglende hiv-kontrol.
English: Some medicines may interact with ritonavir, a medicine that is taken with REYATAZ.
Danish: Noget medicin kan påvirkes af ritonavir, som tages sammen med REYATAZ.
English: The use of REYATAZ with ritonavir may be considered during pregnancy only if the potential benefit justifies the potential risk.
Danish: Brug af REYATAZ med ritonavir kan overvejes under graviditet, hvis den potentielle fordel opvejer den potentielle risiko.
English: Each carton contains one high-density polyethylene (HDPE) bottle or three high-density polyethylene (HDPE) bottles closed with child-resistant polypropylene closure.
Danish: Hver æske indeholder en HDPE-beholder (high density polyethylen) eller tre HDPE-beholdere (high density polyethylen) med børnesikret polypropylenlåg.
English: Administration of REYATAZ and infant formula using an infant bottle is not recommended because the full dose may not be delivered.
Danish: Administration af REYATAZ og modermælkserstatning ved hjælp af en sutteflaske frarådes, da den fulde dosis muligivs ikke indgives.
English: Among patients receiving REYATAZ 300 mg with ritonavir 100 mg, the frequency of jaundice was 19%.
Danish: Blandt patienter, der fik 300 mg REYATAZ med 100 mg ritonavir, var frekvensen af gulsot 19%.
English: REYATAZ oral powder contains 1305.15 mg of sucrose per sachet.
Danish: REYATAZ oralt pulver 1305,15 mg saccharose pr. brev.
English: MARKETING AUTHORISATION NUMBER(S) Bottle pack
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (NUMRE)
English: REYATAZ/ritonavir should be administered 2 hours before or 1 hour after antacids or buffered medicinal products.
Danish: REYATAZ/ritonavir bør administreres 2 timer før eller 1 time efter antacida eller lægemidler med buffer.
English: Blister pack: 30 hard capsules
Danish: Blisterpakning: 30 hårde kapsler
English: The appropriate option listed below is chosen for mixing and administration with liquid infant formula, beverage or food.
Danish: En af nedenstående muligheder vælges for blanding og indgivelse sammen med modermælkserstatning, væske eller føde.
English: If you accidentally take more REYATAZ capsules than your doctor recommended, contact your HIV doctor at once or contact the nearest hospital for advice.
Danish: Hvis du ved en fejltagelse har taget for mange REYATAZ-kapsler, skal du kontakte din hiv-læge eller nærmeste hospital og bede om råd.
English: Through 48 weeks of treatment, the mean changes from baseline in HIV RNA levels for REYATAZ + ritonavir and lopinavir + ritonavir were similar (non-inferior).
Danish: Gennem 48 ugers behandling var middelændringerne i hiv-RNA-niveauer fra baseline for REYATAZ + ritonavir og lopinavir + ritonavir sammenlignelige (ikke-inferior).
English: SPECIAL STORAGE CONDITIONS Bottle pack:
Danish: SÆRLIGE OPBEVARINGSBETINGELSER Beholderpakning:
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Danish: Hos hiv-inficerede patienter med svær immuninsufficiens kan der ved påbegyndelse af antiretroviral kombinationsbehandling (CART) opstå inflammatorisk reaktion på asymptomatiske eller residuale opportunistiske patogener, som kan forårsage alvorlige kliniske tilstande eller forværring af symptomer.
English: Each bottle contains 60 hard capsules.
Danish: Hver beholder indeholder 60 hårde kapsler.
English: For children (at least 3 months of age and weighing at least 5 kg), your child's doctor will decide the right dose based on your child's weight.
Danish: Til børn (mindst 3 måneder og med en kropsvægt på over 5 kg) vil barnets læge beslutte, hvilken dosis, der skal anvendes ud fra barnets vægt.
English: Based on these data and because ritonavir is not expected to have a significant impact on the pharmacokinetics of NRTIs, the co-administration of these medicinal products and REYATAZ is not expected to significantly alter the exposure of the co-administered medicinal products.
Danish: Baseret på disse data, og fordi ritonavir ikke forventes at have signifikant effekt på NRTI'ernes farmakokinetik, forventes samtidig administration af disse lægemidler og REYATAZ ikke at påvirke lægemidlernes eksponering signifikant.
English: There are no dosing recommendations for REYATAZ in paediatric patients less than 3 months of age.
Danish: Der er ingen doseringsanbefalinger for REYATAZ til børn under 3 måneder.
English: REYATAZ (without ritonavir) has been studied in adult patients with severe renal impairment (n=20), including those on haemodialysis, at multiple doses of 400 mg once daily.
Danish: REYATAZ (uden ritonavir) er blevet undersøgt hos voksne patienter med alvorligt nedsat nyrefunktion (n=20), inklusive patienter i hæmodialyse, ved multiple doser på 400 mg en gang dagligt.
English: This co-administration might be considered on a case by case basis if deemed necessary, in patients with suppressed HIV viral loads and with HIV viral strain without any suspected resistance to the HIV regimen.
Danish: Hvis det vurderes nødvendigt, bør samtidig administration kun ske efter individuel vurdering hos patienter med supprimeret hivvirusbelastning og med hivvirusstamme uden formodet resistens over for hivbehandlingen.
English: See the "Instructions for use" at the end of the package leaflet for how to prepare and give a dose of REYATAZ oral powder.
Danish: Se "Brugsvejledning" i slutningen af indlægssedlen om, hvordan REYATAZ oralt pulver tilberedes og indgives.
English: Through 96 weeks of treatment, mean HIV RNA changes from baseline for REYATAZ + ritonavir and lopinavir + ritonavir met criteria for non-inferiority based on observed cases.
Danish: Gennem 96 ugers behandling opfyldte gennemsnitlige hiv-RNA-ændringer fra baseline i uge 96 for REYATAZ + ritonavir og lopinavir + ritonavir, kriterierne for ”ikke inferioritet” baseret på observerede tilfælde.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Read the package leaflet before use.
Danish: ANVENDELSESMÅDE OG ADMINISTRATIONSVEJ Læs indlægssedlen inden brug.
English: a Atazanavir peak concentrations and AUCs were found to be approximately 26-40% higher during the postpartum period (4-12 weeks) than those observed historically in HIV infected, non-pregnant patients.
Danish: Geometrisk gennemsnit (CV%) a Atazanavirs maksimumkoncentration og AUC var ca. 26-40% højere i post partum perioden (4-12 uger) end observeret historisk hos hiv-smittede, ikke-gravide patienter.
English: There was less hyperbilirubinaemia and jaundice in the unboosted REYATAZ group compared with the REYATAZ + ritonavir group (18 and 28 subjects, respectively).
Danish: Der var færre tilfælde af hyperbilirubinæmi og gulsot i gruppen med ikke-boostet REYATAZ sammenlignet med gruppen med REYATAZ + ritonavir (hos henholdsvis 18 og 28 forsøgspersoner).
English: Switching from REYATAZ oral powder to REYATAZ capsules is encouraged as soon as patients are able to consistently swallow capsules.
Danish: Det anbefales at skifte fra REYATAZ oralt pulver til REYATAZ-kapsler, så snart patienten konsekvent er i stand til at sluge kapsler.
English: A clean pair of scissors is used to cut each sachet along the dotted line.
Danish: Der anvendes en ren saks til at åbne brevene langs den stiplede linje.
English: REYATAZ has been evaluated for safety in combination therapy with other antiretroviral medicinal products in controlled clinical trials in 1,806 adult patients receiving REYATAZ 400 mg once daily (1,151 patients, 52 weeks median duration and 152 weeks maximum duration) or REYATAZ 300 mg with ritonavir 100 mg once daily (655 patients, 96 weeks median duration and 108 weeks maximum duration).
Danish: REYATAZ er i kontrollerede kliniske studier evalueret for sikkerhed i kombinationsbehandling med andre antiretrovirale lægemidler hos 1.806 voksne patienter behandlet med REYATAZ 400 mg, én gang dagligt (1.151 patienter, 52 ugers middelvarighed og 152 ugers maksimal varighed) eller REYATAZ 300 mg med ritonavir 100 mg én gang dagligt (655 patienter, 96 ugers middelvarighed og 108 ugers maksimal varighed).
English: Co-administration with REYATAZ has the potential to increase or decrease warfarin concentrations.
Danish: Samtidig administration med REYATAZ kan øge eller reducere koncentrationen af warfarin.
English: Co-administration of a single 300 mg dose of REYATAZ and 100 mg dose of ritonavir with a light meal resulted in a 33% increase in the AUC and a 40% increase in both the Cmax and the 24 hour concentration of atazanavir relative to the fasting state.
Danish: Samtidig indtag af enkeltdosis REYATAZ 300 mg og ritonavir 100 mg og et let måltid medførte en stigning i AUC på 33% og en stigning i såvel Cmax som 24-timerskoncentrationen af atazanavir på 40% i forhold til i fastende tilstand.