FrancophonIA/ELRC3.0 huggingface dataset:
English: Specific reproductive and developmental toxicity studies on treosulfan in animals were not conducted.
Croatian: Nisu provedena specifična ispitivanja reproduktivne i razvojne toksičnosti s treosulfanom u životinja.
English: You must not get pregnant during treatment with this medicine and up to 6 months after treatment.
Croatian: Ne smijete zatrudnjeti tijekom liječenja ovim lijekom te do 6 mjeseci nakon liječenja.
English: Do not store in a refrigerator (2 °C-8 °C) as this might cause precipitation.
Croatian: Nemojte čuvati u hladnjaku (2 °C - 8 °C) jer to može prouzročiti taloženje.
English: The terminal half-life (T1/2ß) of intravenously administered treosulfan (up to 47 g/m²) is approximately 2 hours.
Croatian: Terminalni poluvijek (T1/2ß) intravenski primijenjenog treosulfana (do 47 g/m²) iznosi približno 2 sata.
English: Your child will be monitored for signs of side effects affecting nerves and breathing problems.
Croatian: Vaše će dijete biti pod nadzorom zbog mogućih znakova nuspojava koje zahvaćaju živce te tegoba s disanjem.
English: Children younger than one year (mainly non-malignant diseases, especially immunodeficiencies) experienced more respiratory grade III/IV toxicity, possibly due to pulmonary infections already existing before the start of conditioning treatment.
Croatian: U djece mlađe od jedne godine (uglavnom s nemalignim bolestima, posebice imunodeficijencijama) bilo je više respiratornih toksičnosti III./IV. stupnja, vjerojatno zbog plućnih infekcija koje su postojale i prije početka terapije kondicioniranja.
English: Blood cell counts usually recover after HSCT.
Croatian: Krvna slika obično se oporavi nakon TKMS-a.
English: • decrease in blood cell counts which is the intended effect of the medicine to prepare you for your transplant infusion (all patients: very common)
Croatian: • smanjenje broja krvnih stanica što je namjeravani učinak lijeka kao priprema za infuziju transplantata (svi bolesnici: vrlo često)
English: The effect of treosulfan on the pharmacokinetics of fludarabine is not known.
Croatian: Učinak treosulfana na farmakokinetiku fludarabina nije poznat.
English: Regression analysis of the area under the curve (AUC0-∞) versus treosulfan dose indicated a linear correlation.
Croatian: Regresijska analiza površine ispod krivulje (AUC0-∞) naspram doze treosulfana pokazala je linearnu korelaciju.
English: Cardiac disorders were observed in 25 patients (4.4%).
Croatian: Srčani poremećaji opaženi su u 25 bolesnika (4,4%).
English: Within each frequency group, undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti, nuspojave su prikazane redoslijedom prema sve manjoj ozbiljnosti.
English: Your doctor will monitor your blood counts and liver enzymes regularly to detect and manage these events.
Croatian: Liječnik će Vam redovito pratiti krvnu sliku i jetrene enzime da te pojave otkrije i liječi.
English: Name and address of the manufacturer(s) responsible for batch release medac Gesellschaft für klinische Spezialpräparate mbH Theaterstr.
Croatian: Naziv(i) i adresa(e) proizvođača odgovornog(ih) za puštanje serije lijeka u promet medac Gesellschaft für klinische Spezialpräparate mbH Theaterstr.
English: Treosulfan is given in combination with fludarabine, with thiotepa (intensified regimen; FT10-14TT regimen) or without thiotepa (FT10-14 regimen).
Croatian: Treosulfan se daje u kombinaciji s fludarabinom, s tiotepom (intenzivni režim; režim FT10-14TT) ili bez nje (režim FT10-14).
English: Very common Pruritus
Croatian: Vrlo često pruritus
English: Due to its alkylating mechanism of action treosulfan is characterised as a genotoxic compound with carcinogenic potential.
Croatian: Zbog svog alkilirajućeg mehanizma djelovanja treosulfan se karakterizira kao genotoksičan spoj kancerogenog potencijala.
English: Trecondi may cause symptoms of the menopause (absence of menstrual periods).
Croatian: Trecondi može prouzročiti simptome menopauze (prestanak menstruacija).
English: An Italian group treated 60 TM patients (age range 1-37 years; including 12 adults) with the FT14 plus thiotepa regimen.
Croatian: Talijanska skupina liječila je 60 bolesnika s talasemijom major (raspon dobi 1 - 37 godina; uključujući 12 odraslih) režimom FT14 i tiotepom.
English: Although it cannot be proved that treosulfan was the cause, the use of clonazepam prophylaxis for children younger than 1 year might be considered.
Croatian: Iako se ne može dokazati da im je uzrok bio treosulfan, u djece mlađe od 1 godine može se uzeti u obzir profilaksa klonazepamom.
English: In order to prevent and treat infections, you will be given medicines, such as antibiotics, antifungals or antivirals.
Croatian: Kako bi se spriječile i liječile infekcije, primat ćete lijekove kao što su antibiotici, lijekovi protiv gljivica ili lijekovi protiv virusa.
English: • dry eye
Croatian: • suho oko
English: Therefore, infants ≤ 4 months of age should be monitored for signs of neurological adverse reactions.
Croatian: ≤ 4 mjeseca potrebno pratiti zbog znakova mogućih neuroloških nuspojava.
English: Approximately 25-40% of the treosulfan dose is excreted unchanged with the urine within 24 hours, nearly 90% of which within the first 6 hours after administration.
Croatian: Približno 25 - 40% doze treosulfana izluči se nepromijenjeno u mokraći unutar 24 sata, gotovo 90% od toga unutar prvih 6 sati nakon primjene.
English: This medicine may make you infertile and it may not be possible for you to get pregnant after treatment with it.
Croatian: Ovaj lijek može prouzročiti neplodnost pa nakon liječenja možda nećete moći zatrudnjeti.
English: A total of 37 patients (52.9%) were younger than 12 years.
Croatian: Ukupno 37 bolesnika (52,9%) bilo je mlađe od
English: Men should seek advice about the possibility of sperm preservation before starting therapy.
Croatian: Muškarci moraju potražiti savjet o mogućnosti pohrane sperme prije početka terapije.
English: • different cancer caused by chemotherapeutic treatment (second malignancy)
Croatian: • različite vrste raka prouzročene kemoterapijom (sekundarna zloćudna bolest)
English: All five paediatric patients received alloHSCT for primary immunodeficiencies, i.e. diseases with an increased risk for neoplasias per se.
Croatian: Svih pet pedijatrijskih bolesnika podvrgnuto je postupku aloTKMS zbog primarnih imunodeficijencija, tj. bolesti koje same po sebi nose povećan rizik za novotvorine.
English: • life-threatening condition after bloodstream infection (septic shock)
Croatian: • životno opasno stanje nakon infekcije krvi (septički šok)
English: The latter may also be reduced by the use of a venting needle.
Croatian: Ovo posljednje može se smanjiti i primjenom igle s izlaznim ventilom.
English: There is not sufficient information on the use of treosulfan in children aged less than 1 month.
Croatian: Nema dovoljno informacija o primjeni treosulfana u djece mlađe od 1 mjeseca.
English: One of 564 adult patients (0.2%) developed a second malignancy (breast cancer).
Croatian: Od 564 odrasla bolesnika, u jednog bolesnika (0,2%) razvila se sekundarna maligna bolest (rak dojke).
English: Treosulfan might impair fertility in men and women.
Croatian: Treosulfan može oštetiti plodnost u muškaraca i žena.
English: • blocking of a vein into the liver (adults: uncommon; children and adolescents: not known)
Croatian: • začepljenje vene u jetri (odrasli: manje često; djeca i adolescenti: nepoznato)
English: Conventional dose calculation simply based on BSA results in a significantly higher exposure (AUC) of smaller children and infants with low BSA compared to adolescents or adults.
Croatian: Konvencionalni izračun doze, koji se temelji jednostavno na veličini tjelesne površine, rezultira značajno većom izloženošću (AUC) mlađe djece i dojenčadi male tjelesne površine nego što je to u adolescenata ili odraslih.
English: White crystalline powder.
Croatian: Bijeli kristaličan prah.
English: Rare Confusional state
Croatian: Rijetko stanje konfuzije
English: With a median follow-up of 36 months (range, 4-73), the 5-year overall survival probability was 93% (95% CI 83-97%).
Croatian: S medijanom praćenja od 36 mjeseci (raspon, 4 - 73), vjerojatnost 5-godišnjeg ukupnog preživljenja bila je 93% (95% CI 83 - 97%).
English: All patients engrafted except one, who died on day +11; the median time to neutrophil and platelet recovery was 20 days.
Croatian: U svih je bolesnika udomljavanje matičnih stanica bilo uspješno, osim u jednog bolesnika koji je preminuo na +11. dan; medijan vremena do oporavka neutrofila i trombocita bio je 20 dana.
English: c For testing superiority of treosulfan compared to busulfan.
Croatian: c Za testiranje superiornosti treosulfana u usporedbi s busulfanom.
English: No patient experienced a primary graft failure but one patient with ALL experienced a secondary graft failure.
Croatian: Ni u jednog bolesnika nije došlo do primarnog zatajenja presatka, ali je u jednog bolesnika s ALL-om došlo do sekundarnog zatajenja presatka.
English: Adults with malignant disease
Croatian: Odrasli s malignom bolešću
English: During phases of severe neutropenia (median duration of neutropenic period is 14-17.5 days in adults and 21-24 days in paediatric patients) the risk of infection is increased.
Croatian: Tijekom faza teške neutropenije (medijan trajanja razdoblja neutropenije iznosi 14 - 17,5 dana u odraslih i 21 - 24 dana u pedijatrijskih bolesnika) povećan je rizik od infekcije.
English: No dose accumulation with the recommended daily treatment on three consecutive days was observed.
Croatian: Uz preporučenu svakodnevnu terapiju tijekom tri uzastopna dana nije bila opažena akumulacija doze.
English: Treosulfan destroys the bone marrow cells and enables the transplant of new bone marrow cells which leads to the production of healthy blood cells.
Croatian: Treosulfan uništava stanice koštane srži i omogućava transplantaciju novih stanica koštane srži što dovodi do proizvodnje zdravih krvnih stanica.
English: For testing non-inferiority of treosulfan compared to busulfan.
Croatian: Za testiranje neinferiornosti treosulfana u usporedbi s busulfanom.
English: In addition, acidosis, skin toxicity, nausea, vomiting and gastritis may occur.
Croatian: Osim toga, mogu se pojaviti acidoza, kožna toksičnost, mučnina, povraćanje i gastritis.
English: At concentrations up to 100 µM, treosulfan has no unequivocal effect on CYP1A2, 2C9, 2C19, 2D6, or 3A4 activities in vitro.
Croatian: Pri koncentracijama do 100 µM, treosulfan nema jasan učinak na aktivnost CYP1A2, 2C9, 2C19, 2D6 ili 3A4 in vitro.
English: The epoxides formed alkylate nucleophilic centres of deoxyribonucleic acid (DNA) and are able to induce DNA cross-links which are considered responsible for the stem cell depleting and antineoplastic effects.
Croatian: Epoksidi oblikuju alkilatne nukleofilne centre deoksiribonukleinske kiseline (DNK) i mogu inducirati križno povezivanje lanaca DNK koje se smatra odgovornim za učinke deplecije matičnih stanica i antineoplastične učinke.
English: No dose adjustment is necessary for mild or moderate impairment, but treosulfan is contraindicated in patients with severe impairment (see section 4.3).
Croatian: Prilagodba doze nije potrebna u slučajevima blagog ili umjerenog oštećenja, ali je treosulfan kontraindiciran u bolesnika s teškim oštećenjem (vidjeti dio 4.3).
English: Adequate care and precautions should be taken in the disposal of items (syringes, needles, etc.) used to reconstitute cytotoxic medicinal products.
Croatian: Odgovarajuća pažnja i mjere opreza potrebne su kad se zbrinjava pribor (štrcaljke, igle itd.) upotrijebljen za rekonstituciju citotoksičnih lijekova.
English: Trecondi is a cell-killing (cytotoxic) medicine that is used to decrease the number of blood cells.
Croatian: Trecondi je lijek koji ubija stanice (citotoksičan), a koristi se za smanjenje broja krvnih stanica.
English: The median age of patients was 60 years (range 31-70 years); 25% of patients were older than 65 years.
Croatian: Medijan dobi bolesnika bio je 60 godina (raspon 3170 godina); 25% bolesnika bilo je starije od 65 godina.
English: There is limited information available on treosulfan-based conditioning (FT14 regimen ± thiotepa; see section 4.2) in adult patients with non-malignant disorders (NMD).
Croatian: Dostupne su ograničene informacije o kondicioniranju treosulfanom (režim FT14 ± tiotepa; vidjeti dio 4.2) u odraslih bolesnika s nemalignim poremećajima.
English: • bleeding in the eye, dry eye
Croatian: • krvarenje u oko, suho oko
English: Five cases of a second malignancy (myelodysplastic syndrome, acute lymphoblastic leukaemia, Ewing's sarcoma) were reported by other investigators after treosulfan-based conditioning.
Croatian: Pet slučajeva sekundarne maligne bolesti (mijelodisplastični sindrom, akutna limfoblastična leukemija, Ewingov sarkom) prijavili su drugi ispitivači nakon kondicioniranja treosulfanom.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Carton
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Kutija
English: Very common (may affect more than 1 in 10 people)
Croatian: Vrlo često (može se pojaviti u više od 1 na 10 osoba)
English: Pharmacotherapeutic group: Antineoplastic agents, alkylating agents, ATC code: L01AB02
Croatian: Farmakoterapijska skupina: antineoplastici, alkilirajući lijekovi, ATK oznaka: L01AB02
English: In the absence of haematopoietic stem cell transplantation, the recommended dose of treosulfan would constitute an overdose.
Croatian: Bez transplantacije krvotvornih matičnih stanica, preporučena doza treosulfana smatrala bi se predoziranjem.
English: Pregnant personnel should be excluded from handling cytotoxics.
Croatian: Trudnice među osobljem treba isključiti iz rukovanja citotoksičnim materijalom.
English: • heart not pumping enough blood for the body's needs (heart failure), heart attack, fluid in the sac around the heart (pericardial effusion)
Croatian: • srce ne pumpa dovoljno krvi za potrebe tijela (srčano zatajenje), srčani udar, tekućina u srčanoj ovojnici (perikardijalni izljev)
English: The freedom from transplant-related mortality until day +100 after HSCT (primary endpoint) is 98.6% (90% CI 93.4-99.7%) because one of the 70 patients died due to transplantation/treatment-related cause until day +100 after HSCT.
Croatian: Odsutnost smrtnosti povezane s transplantatom do +100. dana nakon TKMS-a (primarna mjera ishoda) iznosi 98,6% (90% CI 93,499,7%) jer je jedan od 70 bolesnika umro zbog uzroka povezanog s transplantacijom/liječenjem do +100. dana nakon TKMS-a.
English: Transplant-related mortality at 12 months is 2.9% (90% CI 0.9 - 8.9%).
Croatian: Smrtnost povezana s transplantatom u 12. mjesecu bila je 2,9% (90% CI 0,9 - 8,9%).
English: Not known Febrile neutropenia
Croatian: Nepoznato febrilna neutropenija
English: The most frequent adverse reactions were cardiac arrhythmias, e.g. atrial fibrillation (1.2%), sinus tachycardia (0.9%), supraventricular tachycardia (0.4%), and ventricular extrasystole (0.4%).
Croatian: Najčešće nuspojave bile su srčane aritmije, npr. fibrilacija atrija (1,2%), sinusna tahikardija (0,9%), supraventrikularna tahikardija (0,4%) i ventrikularna ekstrasistola (0,4%).
English: Secondary malignancies are well-established complications in long-term survivors after alloHSCT.
Croatian: Sekundarne maligne bolesti dobro su poznate komplikacije u osoba s dugim preživljenjem nakon aloTKMS-a.
English: • leakage of fluid from the capillaries (small blood vessels), high blood pressure, low blood pressure
Croatian: • istjecanje tekućine iz kapilara (male krvne žile), visok krvni tlak, nizak krvni tlak
English: The reconstituted solution contains 50 mg treosulfan per mL and appears as a clear colourless solution.
Croatian: Rekonstituirana otopina sadrži 50 mg treosulfana po ml i izgledom je bistra bezbojna otopina.
English: • bloodstream infection (sepsis)
Croatian: • infekcija krvi (sepsa)
English: P value
Croatian: P vrijednost
English: No pharmacokinetic studies with treosulfan were done in patients with severe renal or hepatic impairment, because such patients are generally excluded from alloHSCT.
Croatian: Farmakokinetička ispitivanja s treosulfanom nisu provedena u bolesnika s teškim oštećenjem bubrežne ili jetrene funkcije jer su takvi bolesnici uglavnom isključeni iz aloTKMS-a.
English: The most frequent adverse reactions reported were nausea (39.5%), stomatitis (36%), vomiting (22.5%), diarrhoea (15.6%), and abdominal pain (10.4%).
Croatian: Najčešće prijavljene nuspojave bile su mučnina (39,5%), stomatitis (36%), povraćanje (22,5%), proljev (15,6%) i bol u abdomenu (10,4%).
English: In juvenile rat toxicity studies treosulfan induced slight retardation of physical development and a slightly delayed time-point of vaginal opening in females.
Croatian: U ispitivanjima toksičnosti u juvenilnih štakora treosulfan je izazvao blago usporenje tjelesnog razvoja i neznatno odgodio vrijeme vaginalnog otvaranja u ženki.
English: This medicine is used in combination with fludarabine.
Croatian: Ovaj se lijek daje u kombinaciji s fludarabinom.
English: If you are a man treated with this medicine, you should not father a child during and up to 6 months after treatment.
Croatian: Ako ste muškarac i liječite se ovim lijekom, ne smijete začeti dijete tijekom liječenja i do 6 mjeseci nakon toga.
English: Treosulfan has moderate influence on the ability to drive and use machines.
Croatian: Treosulfan umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: The cumulative incidence of relapse/progression is 15.7% (90% CI 8.6-22.9%) at month +12.
Croatian: Kumulativna incidencija recidiva/progresije bila je 15,7% (90% CI 8,6 - 22,9%) u +12. mjesecu.
English: Trecondi is used as a treatment before blood stem cell transplantation in adults with cancer and non-cancerous disorders, and in adolescents and children older than one month with cancer.
Croatian: Trecondi se primjenjuje kao terapija prije transplantacije krvnih matičnih stanica u odraslih s rakom i drugim bolestima koje nisu zloćudne te adolescenata i djece starije od jednog mjeseca s rakom.
English: Published data concerning treatment of mice and rats with L-diepoxibutane (the alkylating transformation product of treosulfan) revealed impairment of fertility, uterine-ovarian and sperm development.
Croatian: Objavljeni podaci koji se odnose na liječenje miševa i štakora L-diepoksibutanom (alkilirajući produkt transformacije treosulfana) otkrili su oštećenje plodnosti, razvoja maternice i jajnika te sperme.
English: Maximum plasma levels (mean ± SD) in adult patients after a 2-hour intravenous infusion of 10, 12, or 14 g/m² treosulfan were 306 ± 94 µg/mL, 461 ± 102 µg/mL, and 494 ± 126 µg/mL, respectively.
Croatian: Maksimalne razine u plazmi (srednja vrijednost ± SD) u odraslih bolesnika nakon 2-satne intravenske infuzije treosulfana od 10, 12 ili 14 g/m² bile su 306 ± 94 µg/ml, 461 ± 102 µg/ml odnosno 494 ± 126 µg/ml.
English: • decrease in the oxygen supply to parts of the body (hypoxia)
Croatian: • smanjen dotok kisika u neke dijelove tijela (hipoksija)
English: • decreased counts of white blood cells with fever (febrile neutropenia)
Croatian: • smanjen broj bijelih krvnih stanica s vrućicom (febrilna neutropenija)
English: The lowest frequencies of these adverse reactions were seen with the dose regimen of 10 g/m² per day, day -4 to -2 (20.4%, 30.3%, 13.1%, 5.0%, and 5.5% respectively).
Croatian: Najniže učestalosti tih nuspojava opažene su pri režimu doziranja od 10 g/m² na dan od -4. do -2. dana (20,4%; 30,3%; 13,1%; 5,0% odnosno 5,5%).
English: • Treosulfan should be administered before fludarabine;
Croatian: • Treosulfan je potrebno primijeniti prije fludarabina.
English: There have been isolated reports of seizures in infants (≤ 4 months of age) with primary immunodeficiencies after conditioning treatment with treosulfan in combination with fludarabine or cyclophosphamide.
Croatian: Bilo je izoliranih prijava napadaja u dojenčadi (u dobi ≤ 4 mjeseca) s primarnim imunodeficijencijama nakon terapije kondicioniranja treosulfanom u kombinaciji s fludarabinom ili ciklofosfamidom.
English: Not known Alkalosis
Croatian: Nepoznato alkaloza
English: Pathogens included bacteria (e.g. Staphylococcus, Enterococcus, Corynebacterium), viruses (e.g. cytomegalovirus [CMV], Epstein-Barr virus [EBV], herpes) as well as fungi (e.g. candida).
Croatian: Patogeni su uključivali bakterije (npr. Staphylococcus, Enterococcus, Corynebacterium), viruse (npr. citomegalovirus [CMV], Epstein-Barrov virus [EBV], herpes) te gljivice (npr. kandidu).
English: Prophylactic or empiric anti-infective treatment (bacterial, viral, fungal) should therefore be considered.
Croatian: Stoga je potrebno razmotriti potrebu profilaktičke ili empirijske terapije protiv infekcija (bakterijskih, virusnih, gljivičnih).
English: About 25-40% of treosulfan is excreted in urine; however, an influence of renal function on renal clearance of treosulfan was not observed.
Croatian: Oko 25 - 40% treosulfana izluči se u mokraći; međutim, utjecaj bubrežne funkcije na bubrežni klirens treosulfana nije opažen.
English: Treosulfan is used to prepare patients for bone marrow transplant (haematopoietic stem cell transplantation).
Croatian: Treosulfan se koristi kako bi se bolesnike pripremilo za transplantaciju koštane srži (transplantacija krvotvornih matičnih stanica).
English: Breast-feeding should be discontinued during treatment with treosulfan.
Croatian: Dojenje treba prekinuti za vrijeme liječenja treosulfanom.
English: • problems in the nerves of the arms or legs with symptoms such as numbness, reduced or increased sensitivity, tingling, burning pain (peripheral sensory neuropathy)
Croatian: • teškoće sa živcima ruku ili nogu sa simptomima kao što su utrnulost, smanjena ili povećana osjetljivost, peckanje, žareći bol (periferna senzorna neuropatija)
English: The efficacy and safety of treosulfan-based conditioning was evaluated in 70 patients with acute lymphoblastic leukaemia (ALL), AML, MDS, or juvenile myelomonocytic leukaemia (JMML) who received a conditioning regimen with treosulfan and fludarabine with (n = 65) or without (n = 5) thiotepa (see section 4.2).
Croatian: Djelotvornost i sigurnost kondicioniranja treosulfanom procijenjene su u 70 bolesnika s akutnom limfoblastičnom leukemijom (ALL), AML-om, MDS-om ili juvenilnom mijelomonocitnom leukemijom (JMML) kojima je primijenjen režim kondicioniranja treosulfanom i fludarabinom s tiotepom (n = 65) ili bez nje (n = 5) (vidjeti dio 4.2).
English: The active substance is treosulfan.
Croatian: Djelatna tvar je treosulfan.
English: Therefore, nappies should be changed frequently during 6-8 hours after each dose of this medicine.
Croatian: Stoga je tijekom 6 - 8 sati nakon svake doze ovog lijeka potrebno često mijenjati pelene.
English: As known for other alkylating conditioning agents treosulfan can cause ovarian suppression and amenorrhoea with menopausal symptoms in pre-menopausal women.
Croatian: Kao što je poznato za druga alkilirajuća sredstva za kondicioniranje, treosulfan može prouzročiti supresiju jajnika i amenoreju sa simptomima menopauze u žena u predmenopauzi.
English: Remove the treosulfan powder carefully from the inner surface of the vial by shaking.
Croatian: Protresanjem pažljivo ukonite prah treosulfana s unutarnje površine bočice.
English: Women of childbearing potential/Contraception in males and females Both sexually active men and women of childbearing potential have to use effective contraception during and up to 6 months after treatment.
Croatian: Spolno aktivni muškarci i žene reproduktivne dobi moraju primjenjivati učinkovitu kontracepciju tijekom liječenja te do 6 mjeseci nakon toga.
English: • bruising, low blood pressure
Croatian: • modrice, nizak krvni tlak
English: Treosulfan is for intravenous use as a two-hour infusion.
Croatian: Treosulfan je za intravensku primjenu kao dvosatna infuzija.
English: Profound myelosuppression/pancytopenia is the desired therapeutic effect of conditioning therapy and occurs in all patients.
Croatian: Duboka mijelosupresija/pancitopenija željeni je učinak terapije kondicioniranja i događa se u svih bolesnika.