FrancophonIA/ELRC3.0 huggingface dataset:
English: Also, it can pass into the breast milk and can reach your baby.
Slovenian: Poleg tega se lahko izloča v mleko in ga skupaj z njim zaužije tudi otrok.
English: You can take Oprymea with or without food.
Slovenian: Zdravilo Oprymea lahko jemljete s hrano ali brez nje.
English: Pramipexole is a dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity.
Slovenian: Pramipeksol je agonist dopamina, ki se visoko selektivno in specifično veže na podskupino dopaminskih receptorjev D2, med katerimi ima preferenčno afiniteto za receptorje D3, in ima polno intrinzično aktivnost.
English: You should avoid taking Oprymea together with antipsychotic medicines.
Slovenian: Zdravila Oprymea ne smete jemati hkrati z antipsihotiki.
English: BLISTER/(Alu/Alu)
Slovenian: PRETISNI OMOT/(Al/Al)
English: Take Oprymea prolonged-release tablets only once a day and each day at about the same time.
Slovenian: Vzemite zdravilo Oprymea tablete s podaljšanim sproščanjem samo enkrat na dan in ga jemljite vsak dan ob približno isti uri.
English: Possible independent risk factors for impulse control disorders included dopaminergic treatments and higher doses of dopaminergic treatment, younger age (≤ 65 years), not being married and self-reported family history of gambling behaviours.
Slovenian: Možni neodvisni dejavniki tveganja za motnje nadzora impulzov so bili dopaminergično zdravljenje in dopaminergično zdravljenje z večjimi odmerki, manjša starost (≤ 65 let), neporočenost in samoporočanje o hazarderskem vedenju v družinski anamnezi.
English: Missed dose
Slovenian: Pozabljeni odmerek
English: Tell your doctor if you experience symptoms such as depression, apathy, anxiety, fatigue, sweating or pain after stopping or reducing your Oprymea treatment.
Slovenian: Povejte zdravniku, če se pojavijo simptomi, kot so depresija, apatija, anksioznost, utrujenost, znojenje ali bolečina, potem ko prenehate zdravljenje z zdravilom Oprymea ali vam zmanjšajo odmerek.
English: In a controlled double blind clinical trial of 2 year duration, initial treatment with pramipexole significantly delayed the onset of motor complications, and reduced their occurrence compared to initial treatment with levodopa.
Slovenian: V kontroliranem, dvojno slepem, 2 leti trajajočem kliničnem preskušanju je začetno zdravljenje s pramipeksolom pomembno odložilo nastop motoričnih zapletov in zmanjšalo njihovo pojavljanje v primerjavi z začetnim zdravljenjem z levodopo.
English: The use of Oprymea tablets should be considered.
Slovenian: Presoditi je treba o uporabi Oprymea tablet.
English: Hypotension may occur at the beginning of treatment, especially if pramipexole is titrated too fast.
Slovenian: Hipotenzija se lahko pojavi na začetku zdravljenja, zlasti če odmerek pramipeksola prehitro povečujemo.
English: Concomitant administration with food did not reduce the extent of pramipexole absorption, but the rate of absorption was reduced.
Slovenian: Sočasno jemanje s hrano absorpcije pramipeksola ne zmanjša, zmanjša pa njeno hitrost.
English: Augmentation refers to the earlier onset of symptoms in the evening (or even the afternoon), increase in symptoms, and spread of symptoms to involve other extremities.
Slovenian: Poslabšanje simptomov pomeni pojav simptomov v zgodnejših večernih urah (ali celo popoldne), njihovo večjo intenzivnost in razširitev na druge okončine.
English: If you are switching from Oprymea (immediate release) tablets Your doctor will base your dose of Oprymea prolonged-release tablets on the dose of Oprymea (immediate release) tablets you were taking.
Slovenian: Če prehajate z Oprymea tablet (s takojšnjim sproščanjem) Zdravnik vam bo odmerek Oprymea tablet s podaljšanim sproščanjem določil na podlagi odmerka Oprymea tablet (s takojšnjim sproščanjem), ki ste jih jemali do sedaj.
English: Oprymea is indicated in adults for symptomatic treatment of moderate to severe idiopathic Restless Legs Syndrome in doses up to 0.54 mg of base (0.75 mg of salt) (see section 4.2).
Slovenian: Zdravilo Oprymea je pri odraslih indicirano za simptomatsko zdravljenje zmernega do hudega idiopatskega sindroma nemirnih nog v odmerkih do 0,54 mg pramipeksola (0,75 mg soli) (glejte poglavje 4.2).
English: Intake of a high fat meal induced an increase in peak concentration (Cmax) of about 24% after a single dose administration and about 20% after multiple dose administrations and a delay of about 2 hours in time to reach peak concentration in healthy volunteers.
Slovenian: Pri zdravih prostovoljcih je obrok z veliko vsebnostjo maščob povzročil povečanje največje koncentracije (Cmax) za približno 24 % po jemanju enkratnega odmerka in za približno 20 % po jemanju več odmerkov ter podaljšanje časa do največje koncentracije za približno 2 uri.
English: If you forget to take Oprymea
Slovenian: Če ste pozabili vzeti zdravilo Oprymea
English: Do not stop taking Oprymea without first talking to your doctor.
Slovenian: Zdravilo Oprymea ne prenehajte jemati brez posveta s svojim zdravnikom.
English: The following dose schedule is suggested:
Slovenian: Za zdravljenje je priporočljivo naslednje odmerjanje:
English: Very common: - Nausea (sickness).
Slovenian: Zelo pogosti: - slabost (siljenje na bruhanje).
English: Oprymea can have a major influence on the ability to drive and use machines.
Slovenian: Zdravilo Oprymea ima pomemben vpliv na sposobnost vožnje in upravljanja strojev.
English: Restless Legs Syndrome The dose is usually taken once a day, in the evening, 2-3 hours before bedtime.
Slovenian: Bolniki običajno jemljejo odmerek 1-krat na dan zvečer, 2 do 3 ure pred spanjem.
English: The efficacy and tolerability of an overnight switch from pramipexole tablets to pramipexole prolonged-release tablets at the same daily dose were evaluated in a double-blind clinical study in patients with early Parkinson's disease.
Slovenian: Učinkovitost in prenašanje prehoda s pramipeksol tablet na pramipeksol tablete s podaljšanim sproščanjem v enakem dnevnem odmerku so ocenili v dvojno slepem kliničnem preskušanju pri bolnikih z zgodnjo Parkinsonovo boleznijo.
English: High brain tissue concentrations were observed in the rat (approx. 8-fold compared to plasma).
Slovenian: Pri podganah so opazili visoke koncentracije v možganskih tkivih (približno 8-krat večje kot v plazmi).
English: Tell your doctor if you or your family/carer notices that you are developing mania (agitation, feeling elated or over-excited) or delirium (decreased awareness, confusion or loss of reality).
Slovenian: Povejte zdravniku, če ste sami ali vaši družinski člani/negovalec opazili, da se pri vas razvijata manija (agitacija, vznesenost ali prevelika vznemirjenost) ali delirij (zmanjšano zavedanje, zmedenost ali izguba občutka za resničnost).
English: This side effect has been observed in post-marketing experience.
Slovenian: Ta neželeni učinek so opazili v obdobju trženja.
English: Do not use this medicine after the expiry date which is stated on the packaging after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: If you stop taking Oprymea
Slovenian: Če ste prenehali jemati zdravilo Oprymea
English: The safety and efficacy of Oprymea in children below 18 years has not been established.
Slovenian: Varnost in učinkovitost zdravila Oprymea pri otrocih, mlajših od 18 let, še nista dokazani.
English: No difference was observed for pramipexole as compared to placebo for either the primary endpoint or for any of the secondary efficacy endpoints including YGTSS total score, Patient Global Impression of Improvement (PGI-I), Clinical Global Impression of Improvement (CGI-I), or Clinical Global Impressions of Severity of Illness (CGI-S).
Slovenian: Med pramipeksolom in placebom ni bilo razlik pri primarnem opazovanem dogodku niti pri nobenem od sekundarnih opazovanih dogodkov, kar je pokazala skupna ocena na lestvici YGTSS ter ocene na lestvicah PGI-I (Patient Global Impression of Improvement), CGI-I (Clinical Global Impression of Improvement) in CGI-S (Clinical Global Impressions of Severity of Illness).
English: Pramipexole is bound to plasma proteins to a very low (< 20%) extent, and little biotransformation is seen in man.
Slovenian: Pramipeksol se veže na plazemske proteine v zelo majhni meri ( 20 %) in pri človeku je opažena le manjša biotransformacija.
English: Evaluation of these side effects is based on the following frequencies:
Slovenian: Neželeni učinki so navedeni v skupinah po pogostosti:
English: Endocrine disorders inappropriate antidiuretic hormone secretion
Slovenian: Bolezni endokrinega sistema neustrezno izločanje antidiuretičnega hormona
English: In a placebo-controlled polysomnography study over 3 weeks pramipexole significantly reduced the number of periodic limb movements during time in bed.
Slovenian: V 3-tedenskem s placebom nadzorovanem preskušanju s polisomnografijo je pramipeksol pomembno zmanjšalo število periodičnih premikov okončine v času, ko so bili bolniki v postelji.
English: Patients must be informed of this and advised to exercise caution while driving or operating machines during treatment with Oprymea.
Slovenian: Bolnike je treba nanje opozoriti in jim svetovati, naj bodo med zdravljenjem z zdravilom Oprymea pri vožnji in upravljanju strojev previdni.
English: There is no relevant use of Oprymea in the paediatric population for the indication of Parkinson's Disease.
Slovenian: Zdravilo Oprymea ni namenjeno za uporabo pri pediatrični populaciji za indikacijo Parkinsonova bolezen.
English: How to take Oprymea
Slovenian: Kako jemati zdravilo Oprymea
English: Blister pack (Alu/Alu foil): 20, 30, 60, 90 or 100 tablets, in a box.
Slovenian: Pretisni omot (Al/Al-folija): 20, 30, 60, 90 ali 100 tablet, v škatli.
English: The elimination of pramipexole is dependent on renal function.
Slovenian: Izločanje pramipeksola je odvisno od ledvične funkcije.
English: There is no clinical experience with massive overdose.
Slovenian: Z močno prevelikimi odmerki ni kliničnih izkušenj.
English: Abrupt discontinuation of dopaminergic therapy can lead to the development of a neuroleptic malignant syndrome.
Slovenian: Nagla prekinitev zdravljenja z agonisti dopamina lahko privede do razvoja nevroleptičnega malignega sindroma.
English: In these cases Oprymea may affect your ability to drive and operate machinery.
Slovenian: V teh primerih zdravilo Oprymea lahko zmanjša vašo sposobnost za vožnjo ali upravljanje strojev.
English: Table 2: Restless legs syndrome Body System Very common
Slovenian: Preglednica 2: Sindrom nemirnih nog Organski sistem
English: Pramipexole shows linear kinetics and a small inter-patient variation of plasma levels.
Slovenian: Pramipeksol kaže linearno kinetiko in majhne variacije plazemskih koncentracij med bolniki.
English: Clinical efficacy and safety in Restless Legs Syndrome The efficacy of pramipexole was evaluated in four placebo-controlled clinical trials in approximately 1,000 patients with moderate to very severe idiopathic Restless Legs Syndrome.
Slovenian: Učinkovitost pramipeksola so ocenili v štirih s placebom nadzorovanih kliničnih preskušanjih pri približno 1.000 bolnikih z zmernim do zelo hudim idiopatskim sindromom nemirnih nog.
English: In a Phase I trial, where pramipexole immediate release and prolonged-release tablets were assessed in fasted state, the minimum and peak plasma concentration (Cmin, Cmax) and exposure (AUC) of the same daily dose of pramipexole prolonged-release tablets given once daily and pramipexole tablets given three times a day were equivalent.
Slovenian: V preskušanju I. faze, v katerem so ocenjevali tablete pramipeksola s takojšnjim in s podaljšanim sproščanjem pri teščih preizkušancih, so bile minimalna in največja koncentracija v plazmi (Cmin, Cmax) ter izpostavljenost (AUC) enakovredne ob enakem dnevnem odmerku pramipeksol tablet s podaljšanim sproščanjem, enkrat na dan, in pramipeksol tablet, trikrat na dan.
English: If you forget to take a dose of Oprymea, but remember within 12 hours of your usual time, take your tablet straightaway and then take your next tablet at the usual time.
Slovenian: Če ste pozabili vzeti običajni odmerek zdravila Oprymea, vendar ste se nanj spomnili, preden je poteklo 12 ur od takrat, ko odmerek običajno vzamete, pozabljeno tableto vzemite takoj, naslednjo pa ob običajnem času.
English: Treatment discontinuation
Slovenian: Prekinitev zdravljenja
English: Oprymea prolonged-release tablet is a specially designed tablet from which the active ingredient is gradually released, once the tablet has been ingested.
Slovenian: Zdravilo Oprymea tablete s podaljšanim sproščanjem je posebno zasnovana tableta, iz katere se zdravilna učinkovina sprošča postopoma po zaužitju tablete.
English: Blister (OPA/Alu/desiccant/PE-Alu foil): 10, 30, 90 or 100 prolonged-release tablets, in a box.
Slovenian: Pretisni omot (OPA/Al/sušilno sredstvo/PE-Al folija): 10, 30, 90 ali 100 tablet s podaljšanim sproščanjem, v škatli.
English: - The other ingredients are mannitol, maize starch, pregelatinised maize starch, povidone K25, colloidal anhydrous silica and magnesium stearate.
Slovenian: - Druge sestavine zdravila so manitol, koruzni škrob, predgelirani koruzni škrob, povidon K25, brezvodni koloidni silicijev dioksid in magnezijev stearat.
English: What Oprymea contains - The active substance is pramipexole.
Slovenian: Kaj vsebuje zdravilo Oprymea - Učinkovina je pramipeksol.
English: CGI-I responder rates (much improved, very much improved) were 50.3% (80/159) and 68.5% (111/162) for placebo and pramipexole, respectively (p = 0.001), corresponding to a number needed to treat (NNT) of 6 patients (95%CI: 3.5, 13.4).
Slovenian: Stopnja odziva na lestvici CGI-I (veliko izboljšanje, zelo veliko izboljšanje) je bila 50,3 % (80/159) pri placebu in 68,5 % (111/162) pri pramipeksolu (p = 0,001), kar pomeni, da ima na vsakih 6 zdravljenih bolnikov, en bolnik večjo korist od zdravljenja v primerjavi z bolnikom v kontrolni skupini (95-odstotni IZ: 3,5, 13,4).
English: Remnants in stool
Slovenian: Ostanki v blatu
English: The overall incidence of hallucinations and somnolence was generally higher in the escalation phase with the pramipexole group.
Slovenian: Skupna pogostnost halucinacij in zaspanosti je bila v fazi eskalacije na splošno večja v skupini, ki je prejemala pramipeksol.
English: If a further dose increase is necessary, your doctor may adjust it in steps of 0.26 mg pramipexole.
Slovenian: Če je potrebno odmerek še povečati, ga lahko zdravnik prilagaja postopno po 0,26 mg pramipeksola naenkrat.
English: In half of the 16 patients who did not meet the criterion for maintained efficacy on UPDRS Part II+III score, the change from baseline was considered not clinically relevant.
Slovenian: Pri polovici od 16 bolnikov, pri katerih ni bilo izpolnjeno merilo za ohranitev učinkovitosti pri oceni z lestvico UPDRS, II.
English: Repeated dose toxicity studies showed that pramipexole exerted functional effects, mainly involving the CNS and female reproductive system, and probably resulting from an exaggerated pharmacodynamic effect of pramipexole.
Slovenian: Raziskave toksičnosti po večkratnih odmerkih so pokazale, da pramipeksol kaže funkcionalne učinke, večinoma na osrednji živčni sistem in ženska rodila, ki so verjetno posledica povečanega farmakodinamskega učinka pramipeksola.
English: In patients pramipexole alleviates signs and symptoms of idiopathic Parkinson' s disease.
Slovenian: Pri bolnikih pramipeksol ublaži znake in simptome idiopatske Parkinsonove bolezni.
English: 21 prolonged-release tablets: EU/1/08/469/054
Slovenian: 21 tablet s podaljšanim sproščanjem: EU/1/08/469/054
English: After 12 weeks of treatment the baseline IRLS score improved from 23.5 to 14.1 points for placebo and from 23.4 to 9.4 points for pramipexole (doses combined).
Slovenian: Po 12 tednih zdravljenja se je izhodiščno število točk na lestvici IRLS v skupini, ki je prejemala placebo, zmanjšalo s 23,5 na 14,1, v skupinah, ki so prejemale pramipeksol (skupno za vse odmerke) pa s 23,4 na 9,4 točke.
English: In clinical trials approximately 5% of patients were treated at doses below 1.05 mg of base (1.5 mg of salt).
Slovenian: V kliničnih preskušanjih so približno 5 % bolnikov zdravili z odmerki pod 1,05 mg baze (1,5 mg soli).
English: The symptoms include: - akinesia (loss of muscle movement) - rigid muscles - fever - unstable blood pressure - tachycardia (increased heart rate) - confusion - depressed level of consciousness (e.g. coma).
Slovenian: Simptomi so: - akinezija (nezmožnost gibanja), - otrdele mišice, - vročina, - nestabilen krvni tlak, - tahikardija (povečan srčni utrip), - zmedenost, - zmanjšana zavest (na primer koma).
English: Oprymea can be taken with or without food.
Slovenian: Tablete se lahko vzamejo z ali brez hrane.
English: Decreases in diastolic and systolic pressure and heart rate were noted in the minipig, and a tendency to a hypotensive effect was discerned in the monkey.
Slovenian: Pri pritlikavih prašičih so opazili znižanje diastoličnega in sistoličnega tlaka ter zmanjšanje srčnega utripa, pri opicah pa težnjo k hipotenzivnemu učinku.
English: Therefore, medicinal products that are inhibitors of this active renal elimination pathway or are eliminated by this pathway, such as cimetidine, amantadine, mexiletine, zidovudine, cisplatin, quinine, and procainamide, may interact with pramipexole resulting in reduced clearance of pramipexole.
Slovenian: Zato so z zdravili, ki to aktivno ledvično pot izločanja zavirajo ali se po njej izločajo, npr. s cimetidinom, amantadinom, meksiletinom, zidovudinom, cisplatinom, kininom in prokainamidom možne interakcije s pramipeksolom, katerih posledica je zmanjšan očistek pramipeksola.
English: Each pack of 21 prolonged-release tablets for a 3-week treatment schedule contains: 7 tablets of Oprymea 0.26 mg
Slovenian: Eno pakiranje z 21 tabletami s podaljšanim sproščanjem za tritedensko zdravljenje vsebuje: 7 tablet Oprymea 0,26 mg
English: There is no established antidote for overdose of a dopamine agonist.
Slovenian: Za preveliko odmerjanje dopaminskih agonistov ni uveljavljenega antidota.
English: The treatment of patients with a creatinine clearance below 30 ml/min with Oprymea prolonged release tablets is not recommended as no data are available for this patient population.
Slovenian: Bolnikom s kreatininskim očistkom manjšim od 30 ml/min, ne priporočamo zdravljenja z Oprymea tabletami s podaljšanim sproščanjem, ker za to skupino bolnikov ni podatkov.
English: Pramipexole has been associated with somnolence and episodes of sudden sleep onset, particularly in patients with Parkinson's disease.
Slovenian: Pramipeksol povezujejo z zaspanostjo in nenadnimi epizodami spanja, zlasti pri bolnikih s Parkinsonovo boleznijo.
English: You may experience the following side effects:
Slovenian: Možni so naslednji neželeni učinki:
English: Pharmacodynamic effects In human volunteers, a dose-dependent decrease in prolactin was observed.
Slovenian: Farmakodinamični učinki Pri prostovoljcih so opazili od odmerka odvisno zmanjšane vrednosti prolaktina.
English: Reports in the literature indicate that treatment of Restless Legs Syndrome with dopaminergic medicinal products can result in augmentation.
Slovenian: Iz literature je razvidno, da je poslabšanje simptomov pri zdravljenju sindroma nemirnih nog lahko posledica zdravljenja z dopaminergičnimi zdravili.
English: Therefore, do not take Oprymea if you are pregnant unless your doctor tells you to do so.
Slovenian: Če ste noseči, ne jemljite zdravila Oprymea, razen če vam je tako svetoval zdravnik.
English: Pramipexole is rapidly and completely absorbed following oral administration.
Slovenian: Pramipeksol se po peroralnem jemanju hitro in popolnoma absorbira.
English: CGI-I responder rates (improved, very much improved) were 51.2% and 72.0% for placebo and pramipexole, respectively (difference 20% CI 95%: 8.1%; 31.8%, p<0.0005).
Slovenian: Odstotek odzivnosti na zdravljenje je bil glede na oceno, pridobljeno z lestvico CGI-I (izboljšanje, zelo veliko izboljšanje), pri placebu 51,2 %, pri pramipeksolu pa 72,0 % (razlika 20 %, 95-interval zaupanja: 8,1 %; 31,8 %, p < 0,0005).
English: Placebocontrolled clinical trials included approximately 1,800 patients of Hoehn and Yahr stages I - V treated with pramipexole.
Slovenian: V s placebom kontroliranih kliničnih preskušanjih je bilo vključenih približno 1.800 bolnikov v stadijih I-V po Hoehnovi in Yahru, ki so se zdravili s pramipeksolom.
English: Oprymea contains the active substance pramipexole and belongs to a group of medicines known as dopamine agonists which stimulate dopamine receptors in the brain.
Slovenian: Zdravilo Oprymea vsebuje zdravilno učinkovino pramipeksol in spada v skupino zdravil, poimenovanih dopaminski agonisti, ki spodbujajo dopaminske receptorje v možganih.
English: - The other ingredients are hypromellose, maize starch, colloidal anhydrous silica and magnesium stearate.
Slovenian: - Druge sestavine zdravila so hipromeloza, koruzni škrob, brezvodni koloidni silicijev dioksid in magnezijev stearat.
English: Children and adolescents Oprymea is not recommended for use in children or adolescents under 18 years.
Slovenian: Otroci in mladostniki Uporabe zdravila Oprymea pri otrocih in mladostnikih, mlajših od 18 let, ne priporočamo.
English: 10 prolonged-release tablets 30 prolonged-release tablets 90 prolonged-release tablets 100 prolonged-release tablets
Slovenian: 10 tablet s podaljšanim sproščanjem 30 tablet s podaljšanim sproščanjem 90 tablet s podaljšanim sproščanjem 100 tablet s podaljšanim sproščanjem
English: Pramipexole alleviates parkinsonian motor deficits by stimulation of dopamine receptors in the striatum.
Slovenian: Pramipeksol ublaži motorične motnje pri Parkinsonovi bolezni s stimulacijo receptorjev dopamina v striatumu.
English: Oprymea should not be used during pregnancy unless clearly necessary, i.e. if the potential benefit justifies the potential risk to the foetus.
Slovenian: Zdravilo Oprymea uporabljamo med nosečnostjo le, če potencialne koristi zdravljenja opravičujejo potencialno tveganje za plod.
English: Two trials were conducted in patients with early Parkinson's disease and one trial was conducted in patients with advanced Parkinson's disease.
Slovenian: Dve preskušanji sta zajeli bolnike z zgodnjo obliko Parkinsonove bolezni, eno pa bolnike z njeno napredovalo stopnjo.
English: The daily dose should not exceed 6 tablets Oprymea 0.088 mg or a dose of 0.54 mg (0.75 mg pramipexole salt).
Slovenian: Dnevni odmerek ne sme preseči 6 tablet zdravila Oprymea po 0,088 mg oziroma 0,54 mg (0,75 mg pramipeksolijeve soli).
English: The daily dose you take of Oprymea increases each week.
Slovenian: Vsak teden vzamete večji dnevni odmerek zdravila Oprymea.
English: Pramipexole is commonly associated with somnolence and has been associated uncommonly with excessive daytime somnolence and sudden sleep onset episodes (see also section 4.4).
Slovenian: Pramipeksol pogosto povezujejo z zaspanostjo, občasno tudi s preveliko zaspanostjo čez dan in epizodami nenadnega spanca (glejte tudi poglavje 4.4).
English: In a carcinogenicity study, male rats developed Leydig cell hyperplasia and adenomas, explained by the prolactin-inhibiting effect of pramipexole.
Slovenian: V raziskavi kancerogenosti so pri podganjih samcih razvili hiperplazijo Leydigovih celic in adenome, kar so razložili z dejstvom, da pramipeksol zavira sintezo prolaktina.
English: OR
Slovenian: CI
English: Restless Legs Syndrome, most common adverse reactions The most commonly (≥ 5%) reported adverse drug reactions in patients with Restless Legs Syndrome treated with pramipexole were nausea, headache, dizziness and fatigue.
Slovenian: Sindrom nemirnih nog, najpogostejši neželeni učinki Najpogostejši neželeni učinki (≥ 5 %), o katerih so poročali pri bolnikih s sindromom nemirnih nog, ki so se zdravili s pramipeksolom, so bili slabost, glavobol, omotica in utrujenost.