FrancophonIA/ELRC3.0 huggingface dataset:
English: In the losartan group 44% of the patients received HCTZ, in the atenolol group 38%.
Slovenian: V skupini, ki je prejemala losartan, je 44 % bolnikov prejemalo tudi HCTZ, v skupini, ki je prejemala atenolol, pa 38 %.
English: 2700-547 Amadora, Portugal
Slovenian: 2700-547 Amadora, Portugalska
English: Cozaar Comp. and Cozaar Comp Forte (losartan/hydrochlorothiazide) have been included in the list of products for Summary of Products Characteristics (SPC) harmonisation, drawn up by the CMD(h), in accordance with Article 30(2) of Directive 2001/83/EC, as amended.
Slovenian: Zdravili Cozaar Comp. in Cozaar Comp Forte (losartan/hidroklorotiazid) sta bili vključeni na seznam zdravil za uskladitev povzetka glavnih značilnosti zdravila (SPC), ki ga je pripravil CMD(h) v skladu s členom 30(2) Direktive 2001/83/ES, kakor je bila spremenjena.
English: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.- viale Shakespeare 47, 00144 Rome, Italy
Slovenian: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.- viale Shakespeare 47 , 00144 Rim, Italija
English: Laboratory Test Interactions
Slovenian: Vpliv na laboratorijske teste
English: • if you need to have an anaesthetic (even at the dentist) or before surgery, or if you are going to have tests to check your parathyroid function, you must tell the doctor or medical staff that you are taking Losartan potassium and Hydrochlorothiazide tablets.
Slovenian: • če boste morali dobiti anestezijo (tudi pri zobozdravniku) ali boste operirani, ali greste na teste delovanja obščitnične žleze, morate zdravniku ali medicinskemu osebju povedati, da jemljete tablete s kalijevim losartanom in hidroklorotiazidom.
English: • as first step treatment in patients with moderate to severe hypertension and in patients with high or very high cardiovascular risk
Slovenian: • kot prvi korak pri zdravljenju bolnikov z zmerno do hudo hipertenzijo in pri bolnikih z visokim ali zelo visokim kardiovaskularnim tveganjem,
English: Carbamazepine Risk of symptomatic hyponatremia.
Slovenian: Karbamazepin Tveganje za simptomatsko hiponatriemijo.
English: In clinical studies of at least one year's duration, the antihypertensive effect was maintained with continued therapy.
Slovenian: V kliničnih študijah, ki so trajale vsaj eno leto, se je med rednim zdravljenjem antihipertenzivni učinek vzdrževal.
English: The mechanism of the antihypertensive effect of thiazide diuretics is not fully known.
Slovenian: Mehanizem antihipertenzivnega delovanja tiazidov ni popolnoma znan.
English: Both losartan and its principal active metabolite have a far greater affinity for the AT1 receptor than for the AT2 receptor.
Slovenian: Oba, losrtan in njegov osnovni aktivni presnovek, imata precej večjo afiniteto za AT1 receptor kot za AT2 receptor.
English: Characteristics in Patients
Slovenian: Značilnosti bolnikov
English: As with other medicines which affect the excretion of sodium, lithium excretion may be reduced.
Slovenian: Kot pri drugih zdravilih, ki vplivajo na izločanje natrija, se lahko zmanjša izločanje litija.
English: In addition, in an overall analysis of 16 double-blind clinical trials in 4131 patients, the incidence of spontaneously reported cough in patients treated with losartan was similar (3.1%) to that of patients treated with placebo (2.6%) or hydrochlorothiazide (4.1%), whereas the incidence with ACE inhibitors was 8.8%.
Slovenian: Poleg tega je skupna analiza 16 dvojno slepih kliničnih preizkušanj s 4.131 bolniki pokazala, da je bila pojavnost kašlja iz spontanih poročil pri bolnikih, zdravljenih z losartanom, podobna (3,1 %) kot pri bolnikih, ki so prejemali placebo (2,6 %) ali hidroklorotiazid (4,1 %), medtem ko je bila pojavnost pri zaviralcih ACE 8,8 %.
English: Other antihypertensive drugs Additive effect.
Slovenian: Druga antihipertenzivna zdravila Aditivni učinki.
English: In addition, a prevention indication for HCTZ alone, based on the LIFE data is not considered approvable.
Slovenian: Poleg tega se preventivna indikacija za samostojni HCTZ na podlagi podatkov iz študije LIFE ne upošteva kot primerna za odobritev.
English: Losartan has no effect on autonomic reflexes and no sustained effect on plasma norepinephrine.
Slovenian: Losartan nima učinka na avtonomne reflekse in nima trajnega učinka na količino noradrenalina v plazmi.
English: Therapy with Cozaar Comp should be discontinued and the patient observed closely.
Slovenian: Zdravljenje z zdravilom Cozaar Comp je treba prekiniti in bolnika pozorno opazovati.
English: Hypotension and electrolyte/fluid imbalance
Slovenian: Hipotenzija ter neravnovesja elektrolitov/tekočin
English: You should not take Cozaar Comp in the first 12 weeks of pregnancy, and you must not take them at all after the 13th week as their use during pregnancy may possibly be harmful to the baby.
Slovenian: Zdravila Cozaar Comp naj se v prvih 12 tednih nosečnosti ne bi jemalo, od 13. tedna dalje pa je njegova uporaba celo prepovedana, ker lahko škoduje otroku.
English: Overdosage can cause a drop in blood pressure, palpitations, slow pulse, changes in blood composition, and dehydration.
Slovenian: Prevelik odmerek lahko povzroči padec krvnega tlaka, palpitacije, počasen utrip, spremembe v sestavi krvi in dehidracijo.
English: Cozaar Comp is indicated for the treatment of essential hypertension (high blood pressure).
Slovenian: Zdravilo Cozaar Comp je indicirano za zdravljenje esencialne hipertenzije (visokega krvnega tlaka).
English: Losartan has been shown to have a mild and transient uricosuric effect.
Slovenian: Losartan ima blag in prehoden urikozurični učinek.
English: Therefore, losartan/hydrochlorothiazide should not be administered to children and adolescents.
Slovenian: Zato se losrtan/hidroklorotiazid pri otrocih in mladotnikih ne sme uporabljati.
English: • if you have severely impaired kidney function or your kidneys are not producing any urine.
Slovenian: • če imate hudo okvaro ledvic ali vaše ledvice ne tvorijo urina.
English: The main areas of disharmony of the existing Summary of Product Characteristics were section 4.1 Therapeutic Indications, section 4.3 Contraindications, and section 4.4 Special Warnings and Precautions for Use.
Slovenian: Glavna področja neskladnosti v obstoječem povzetku glavnih značilnosti zdravila so bila poglavje 4.1 Terapevtske indikacije, poglavje 4.3 Kontraindikacije ter poglavje 4.4 Posebna opozorila in previdnostni ukrepi.
English: Periodic determination of serum electrolytes should be performed at appropriate intervals in such patients.
Slovenian: Pri teh bolnikih je treba v primernih intervalih periodično spremljati elektrolite v serumu.
English: Cozaar Comp should not be initiated during pregnancy.
Slovenian: Zdravljenja z zdravilom Cozaar Comp se ne sme začeti med nosečnostjo.
English: 6.6 Special precautions for disposal <and other handling> No special requirements.
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje Nobenih posebnih zahtev.
English: Thiazides should be discontinued before carrying out tests for parathyroid function.
Slovenian: Jemanje tiazidov je treba prekiniti pred izvedbo testov paratiroidne funkcije.
English: A recent review in the BMJ shows that specifically the preventive effect on stroke of atenolol is lower than for other antihypertensives; RR of 1.26 (95%CI: 1.15 to 1.38).
Slovenian: Nedavno poročilo, ki je bilo objavljeno v BMJ, kaže, da je preventivni učinek atenolola na možgansko kap manjši kot pri drugih zdravilih proti hipertenziji; RR od 1,26 (95 % CI: 1,15 do 1,38).
English: Therefore, the use of Cozaar Comp tablets is not recommended.
Slovenian: Zato uporabe tablet Cozaar Comp ne priporočamo.
English: Next to these effects, there are further adverse reactions reported after the introduction of the product to the market as follows:
Slovenian: Poleg teh učinkov, so po prihodu zdravila na trg poročali še o naslednjih neželenih učinkih:
English: • 2nd and 3rd trimester of pregnancy (see section 4.4 and 4.6)
Slovenian: • 2. in 3. trimesečje nosečnosti (glejte poglavji 4.4 in 4.6).
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine (see section 6.1).
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze-galaktoze tega zdravila ne smejo jemati (glejte poglavje 6.1).
English: Cozaar Comp works equally well in and is equally well tolerated by most older and younger adult patients.
Slovenian: Zdravilo Cozaar Comp enako dobro deluje pri večini starejših in mlajših bolnikov.
English: Increase in dosage of probenecid or sulfinpyrazone may be necessary.
Slovenian: Morda je treba povečati odmerke probenecida ali sulfinpirazona.
English: Pressor amines (e.g., adrenaline) Possible decreased response to pressor amines but not sufficient to preclude their use.
Slovenian: Presorni amini (npr. adrenalin) Možna je zmanjšana odzivnost na presorske amine, vendar ne toliko, da bi to oviralo njihovo uporabo.
English: The CHMP was concerned that there is no evidence that supports each of the two substances in Cozaar Comp (losartan and HCTZ) having a documented contribution to the claimed indication as required by the The NfG on fixed dose combination products.
Slovenian: CHMP je izrazil zaskrbljenost glede odsotnosti dokazov, ki bi podpirali dokumentiran prispevek vsake od dveh snovi v zdravilu Cozaar Comp (losartan in HCTZ), kot to zahteva NfG o zdravilih s fiksno kombinacijo odmerkov.
English: The antihypertensive effect of Cozaar Comp is sustained for a 24-hour period.
Slovenian: Antihipertenzivni učinek zdravila Cozaar Comp se vzdržuje 24 ur.
English: There have been isolated reports of haemolytic anaemia occurring with concomitant use of hydrochlorothiazide and methyldopa.
Slovenian: Poročali so o posameznih primerih hemolitične anemije pri sočasni uporabi hidroklorotiazida in metildope.
English: The MAH was asked to provide data on safety and efficacy for these subgroups of patients (Losartan, Atenolol, Losartan + HCTZ, Atenolol + HCTZ) in order to gain more insight into the contribution of HCTZ to the overall benefit risk ratio.
Slovenian: Od imetnika dovoljenja za promet z zdravilom so zahtevali podatke o varnosti in učinkovitosti pri omenjenih podskupinah bolnikov (losartan, atenolol, losartan + HCTZ, atenolol + HCTZ), da bi z njimi dobili boljši vpogled v prispevek, ki ga ima HCTZ na skupno razmerje med koristnimi učinki in tveganjem.
English: Angiotensin II, a potent vasoconstrictor, is the primary active hormon of the renin-angiotensin system and an important determinant of the pathophysiology of hypertension.
Slovenian: Angiotenzin II, močan vazokonstriktor, je primarni aktivni hormon sistema renin/angiotenzin in pomemben faktor v patofiziologiji hipertenzije.
English: Furthermore, losartan does not inhibit ACE (kininase II), the enzyme that degrades bradykinin.
Slovenian: Nadalje, losartan ne zavira ACE (kininaze II), encima, ki razgrajuje bradikinin.
English: More than 50% of those patients reaching the target BP on the FDC within 4 weeks did not require a combination.
Slovenian: Več kot 50 % bolnikov, ki so bili deležni zdravljenja s fiksno kombinacijo odmerkov in so v štirih tednih dosegli ciljni krvni tlak, ni potrebovalo kombinacije zdravil.
English: During the referral procedure, the MAH proposed amending the indication to substitute “cardiovascular morbidity and mortality” with “stroke”.
Slovenian: Med napotitvenim postopkom je imetnik dovoljenja za promet z zdravilom predlagal spremembo indikacije, v kateri bi „kardiovaskularno obolevnost in umrljivost“ zamenjal z izrazom „možganska kap“.
English: Use in the elderly Dosage adjustment is not usually necessary for the elderly.
Slovenian: Uporaba pri starejših bolnikih Pri starejših bolnikih odmerka običajno ni treba prilagoditi.
English: When compared to only 8.2% of patients that can reach target BP somewhat faster compared to a stepwise approach, the risk benefit ratio is negative both for patients with severe and for patients with mild to moderate hypertension.
Slovenian: Če ta odstotek primerjamo s samo 8,2 % bolnika, ki so ciljni krvni tlak dosegli malce hitreje kot tisti, ki so bili deležni zdravljenja po korakih, je razmerje med koristnimi učinki in tveganjem negativno tako za bolnike s hudo kot za bolnike z blago do zmerno hipertenzijo.
English: The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.
Slovenian: Najverjetnejši simptomi bi bili hipotenzija in takihardija; bradikardija se lahko pojavi zaradi parasimpatične (vagalne) stimulacije.
English: Quinta da Fonte - Edifício Vasco da Gama, 19 - Porto Salvo P.O.
Slovenian: Quinta da Fonte - Edifício Vasco da Gama, 19 - Porto Salvo
English: Do not use Cozaar Comp after the expiry date which is stated on the container.
Slovenian: Zdravila Cozaar Comp ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini.
English: As with all antihypertensive therapy, symptomatic hypotension may occur in some patients.
Slovenian: Kot pri vsakem antihipertenzivnem zdravljenju se tudi pri tem lahko pri nekaterih bolnikih pojavi simptomatska hipotenzija.
English: • if you are on a salt-restricted diet
Slovenian: • če ste na dieti s hrano z zmanjšano količino soli.
English: If calcium supplements must be prescribed, serum calcium levels should be monitored and calcium dosage should be adjusted accordingly.
Slovenian: Če morate predpisati dodatke kalcija, morate spremljati količino kalcija v serumu ter ustrezno prilagoditi odmerek kalcija.
English: In addition to the active metabolite, inactive metabolites are formed, including two major metabolites formed by hydroxylation of the butyl side chain and a minor metabolite, an N-2 tetrazole glucuronide.
Slovenian: Poleg aktivnega metabolita se tvorijo tudi neaktivni presnovki, vključno z dvema večjima, ki nastaneta s hidroksilacijo butilne stranske verige, in enim manjšim, N-2 tetrazol glukuronidom.
English: This composite endpoint can be considered as representative for CV morbidity and mortality, and has translated into this indication in many medicinal products that have been discussed in the CHMP (e.g. statins).
Slovenian: Ta sestavljeni pokazatelj pomeni kardiovaskularno obolevnost in umrljivost in je bila kot taka indikacija prevedena pri mnogih zdravilih, o katerih so razpravljali v CHMP (npr. statini).
English: Investigations Rare: Hyperkalaemia, elevation of ALT
Slovenian: Preiskave Redke: hiperkaliemija, zvišanje ALT
English: Lindenplatz 1 85540, Haar Germany
Slovenian: Lindenplatz 1 85540, Haar Nemčija
English: Hydrochlorothiazide may reduce both plasma volume and uteroplacental blood flow.
Slovenian: Hidroklorotiazid lahka zmanjša tako volumen plazme kot tudi uteroplacentarni krvni obtok.
English: Metformin should be used with caution because of the risk of lactic acidosis induced by possible functional renal failure linked to hydrochlorothiazide.
Slovenian: Metformin je treba uporabljati previdno zaradi tveganja za laktacidozo, ki jo povzroči možna ledvična odpoved, povezana s hidroklorotiazidom.
English: Diuretic agents such as the hydrochlorothiazide contained in Cozaar Comp may interact with other medicines.
Slovenian: Diuretiki, kot je hidroklorotiazid v zdravilu Cozaar Comp, lahko medsebojno deluje z drugimi zdravili.
English: Dosage adjustment of antidiabetic agents, including insulin, may be required (see section 4.5).
Slovenian: V tem primeru je lahko treba prilagoditi odmerjanje antidiabetičnega zdravila, vključno z insulinom (glejte poglavje 4.5).
English: What Cozaar Comp is and what it is used for Before you take Cozaar Comp How to take Cozaar Comp Possible side effects
Slovenian: Kaj je zdravilo Cozaar Comp in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Cozaar Comp Kako jemati zdravilo Cozaar Comp Možni neželeni učinki
English: Cozaar Comp is effective in reducing blood pressure in males and females, blacks and non-blacks and in younger (<65 years) and older (≥65 years) patients and is effective in all degrees of hypertension.
Slovenian: Zdravilo Cozaar Comp je učinkovito za znižanje krvnega tlaka pri moških in ženskah, pri črncih in ostalih rasah, pri mlajših (< 65 let) in starejših (≥ 65 let) bolnikih ter za vse stopnje hipertenzije.
English: The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.
Slovenian: Količine hidrokloritizida, ki se odstrani s hemodializo, niso ugotovili.
English: Studies in rats indicate that losartan crosses the bloodbrain barrier poorly, if at all.
Slovenian: Raziskave na podganah kažejo, da losartan v zelo majhnem deležu, če sploh, prehaja skozi krvno-možgansko bariero.
English: The plasma concentrations of losartan and its active metabolite and the absorption of hydrochlorothiazide in elderly hypertensives are not significantly different from those in young hypertensives.
Slovenian: Plazemske koncentracije losartana in njegovega aktivnega presnovka ter absorbcija hidroklorotiazida pri starejših hipertonikih niso bile pomembno drugačne od tistih pri mladih moških hipertonikih.
English: Taking Cozaar Comp with food and drink
Slovenian: Jemanje zdravila Cozaar Comp skupaj s hrano in pijačo
English: Despite these increases, antihypertensive activity and suppression of the plasma aldosterone concentration are maintained, indicating effective angiotensin II receptor blockade.
Slovenian: Kljub tem povečanjem pa se ohranjata antihipertenzivna aktivnost in zmanjševanje koncentracije aldosterona v plazmi, kar kaže na učinkovito blokado receptorjev za angiotenzin II.
English: Thiazides pass the placental barrier and are found in cord blood.
Slovenian: Tiazidi prehajajo skozi posteljico in jih najdemo v popkovnični krvi.
English: Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts.
Slovenian: Tiazidi vplivajo na renalni tubularni mehanizem reabsorpcije elektrolitov in tako neposredno povečujejo izločanje natrija in klorida v približno enakih količinah.
English: • if you have narrowing of the arteries (atherosclerosis), angina pectoris (chest pain due to poor heart function)
Slovenian: • če imate zožane arterije (aterosklerozo), angino pektoris (bolečino v prsnem košu zaradi šibkega delovanja srca).
English: If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor.
Slovenian: Če katerikoli neželeni učinek postane resen ali če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
English: In case of high dosages of salicylates hydrochlorothiazide may enhance the toxic effect of the salicylates on the central nervous system.
Slovenian: V primeru velikih odmerkov salicilatov lahko hidroklorotiazid poveča toksični učinek salicilatov na centralno živčevje.
English: Since then the beneficial effect of atenolol regarding CV morbidity and mortality has been questioned.
Slovenian: Od takrat dalje obstaja dvom o koristnem učinku atenolola na kardiovaskularno obolevnost in umrljivost.
English: The reason for this broader indication is that the LIFE study was not a placebo-controlled study, studying the effect on stroke only compared to placebo, but an actively controlled study, comparing a losartan based with an atenolol based antihypertensive treatment using a primary composite endpoint of CV death, stroke and MI.
Slovenian: Razlog za to razširjeno indikacijo je dejstvo, da študija LIFE ni bila s placebom nadzorovana študija, v kateri bi raziskovali učinek na možgansko kap samo v primerjavi s placebom, temveč je bila aktivno nadzorovana študija, v kateri so primerjali zdravljenje proti hipertenziji na podlagi losartana v primerjavi s tistim na podlagi atenolola, pri tem pa so uporabili sestavljeni primarni pokazatelj za kardiovaskularno smrt, možgansko kap in miokardni infarkt.
English: Patients with primary aldosteronism generally will not respond to antihypertensive drugs acting through inhibition of the renin-angiotensin system.
Slovenian: Bolniki s primarnim hiperaldosteronizmom se na zdravljenje z antihipertenzivi, ki zavirajo sistem renin-angiotenzin, večinoma ne odzovejo.
English: • Increased potassium levels (which can cause an abnormal heart rhythm), decreased haemoglobin levels.
Slovenian: • zvišana količina kalija (ki lahko povzroči nenormalen srčni ritem), znižan hemoglobin
English: In case of diuretic-induced dehydration, there is an increased risk of acute renal failure, especially with high doses of the iodine product.
Slovenian: V primeru z diuretikom povzročene dehidracije obstaja povečano tveganje za akutno ledvično odpoved, še posebej pri velikih odmerkih jodovega pripravka.
English: Foetal toxicity in rats, as evidenced by a slight increase in supernumerary ribs in the F1 generation, was observed when females were treated prior to and throughout gestation.
Slovenian: Pri podganah so škodljive učinke na plod, ki so se pokazali z rahlim povečanjem pojavnosti odvečnih reber v generaciji F1, opazili, če so samice zdravili pred in med brejostjo.
English: Hertfordshire, EN11 9BU United Kingdom
Slovenian: Hertfordshire EN11 9BU Velika Britanija
English: A severe allergic reaction (rash, itching, swelling of the face, lips, mouth or throat that may cause difficulty in swallowing or breathing).
Slovenian: Huda alergijska reakcija (izpuščaj, srbenje, otekanje obraza, ustnic, otekanje v ustih ali žrelu, ki lahko oteži požiranje ali dihanje).
English: • if you have or have had severe vomiting and/or diarrhoea
Slovenian: • če ste močno bruhali in/ali imeli hudo drisko.
English: Following an oral dose of 14C-labeled losartan in man, about 35% of radioactivity is recovered in the urine and 58% in the feces.
Slovenian: Po peroralnem/intravenskem odmerku s 14C označenega losartana pri človeku najdemo približno 35 %radioaktivnosti v urinu, 58 % pa v blatu.
English: The adverse events were restricted to those which were formerly observed with losartan potassium salt and/or hydrochlorothiazide.
Slovenian: Neželeni učinki so bili omejeni na tiste, ki so jih že predhodno opazili pri kalijevem losartanatu in/ali hidroklorotiazidu.
English: Important information about some of the ingredients of Cozaar Comp
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Cozaar Comp
English: About 14% of an intravenously- or orally-administered dose of losartan is converted to its active metabolite.
Slovenian: Približno 14 % intravensko ali peroralno danega odmerka losartana se pretvori v njegov aktivni presnovek.
English: • Low blood pressure, which may be associated with changes in posture (feeling light-headed or weak when you stand up, angina (chest pain), abnormal heartbeat, cerebrovascular accident (TIA, “mini-stroke”), heart attack, palpitations,
Slovenian: • nizek krvni tlak, ki je lahko povezan s spremembo položaja (občutek omotičnosti ali slabotnosti, ko vstanete, angina pektoris (bolečina v prsnem košu), nenormalen srčni utrip, možganskožilni dogodek (TIA - mini kap), srčni napad, palpitacije
English: In patients with left ventricular failure, 25 mg and 50 mg doses of losartan produced positive hemodynamic and neurohormonal effects characterized by an increase in cardiac index and decreases in pulmonary capillary wedge pressure, systemic vascular resistance, mean systemic arterial pressure and heart rate and a reduction in circulating levels of aldosterone and norepinephrine, respectively.
Slovenian: Pri bolnikih s popuščanjem levega ventrikla so 25 mg in 50 mg odmerki losartana povzročili pozitivne hemodinamske in nevrohormonske učinke, za katere so bili značilni povečan srčni indeks in zmanjšanje pljučnega kapilarnega zagozditvenega tlaka, sistemskega vaskularnega upora, povprečnega sistemskega arterijskega tlaka in srčne frekvence ter zmanjšanje ravni cirkulirajočega aldosterona oz. noradrenalina.
English: • Inflammation of blood vessels, which is often associated with a skin rash or bruising,
Slovenian: • vneje krvnih žil, ki je pogosto povezano s kožnim izpuščajem ali modricami
English: There is no experience with the use of Cozaar Comp in children.
Slovenian: Izkušenj z uporabo zdravila Cozaar Comp pri otrocih nimamo.