FrancophonIA/ELRC3.0 huggingface dataset:
English: The doctor or nurse will check that the expiry date on the label has not been passed before administering the injection to you.
Slovenian: Zdravnik ali medicinska sestra bosta preverila, da datum izteka roka uporabnosti ni pretekel, preden vam bosta dala injekcijo.
English: Usually, treatment should not exceed one day.
Slovenian: Zdravljenje običajno ne sme trajati dlje kot en dan.
English: This medicine will help your haemoglobin return to normal and restore the transport of oxygen in the blood.
Slovenian: To zdravilo bo pripomoglo, da vaš hemoglobin spet postane normalen, in bo ponovno vzpostavilo prenos kisika v krvi.
English: Treatment does not usually exceed one day.
Slovenian: Zdravljenje običajno ne traja dlje kot en dan.
English: They may appear green or blue - increased sensitivity of your skin to light (photosensitivity)
Slovenian: Videti je zeleno ali modro - povečana občutljivost vaše kože na svetlobo (fotosenzitivnost)
English: The patient should be maintained under observation, the methaemoglobin level should be monitored and appropriate supportive measures taken as necessary.
Slovenian: Bolnika je treba opazovati, spremljati je treba raven methemoglobina in po potrebi uporabiti ustrezne podporne ukrepe.
English: It must not be administered by subcutaneous or intrathecal injection.
Slovenian: Ne sme se ga injicirati podkožno ali intratekalno.
English: No dose adjustment is necessary.
Slovenian: Starejši Prilagoditev odmerka ni potrebna.
English: However, the risk is limited as the medicinal product is intended for acute administration only in emergency situations at hospital.
Slovenian: Vendar pa je tveganje omejeno, saj je zdravilo namenjeno za akutno uporabo samo v nujnih primerih v bolnišnici.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before you are given this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte se z zdravnikom, preden vzamete to zdravilo.
English: If not used immediately, in-use storage times and conditions are the responsibility of the user.
Slovenian: Če se zdravila ne uporabi takoj, je za čas shranjevanja in pogoje med uporabo odgovoren uporabnik.
English: Infants 3 months old or younger
Slovenian: Otroci, stari 3 mesece ali mlajši
English: • Deficiency in NADPH (nicotinamide adenine dinucleotide phosphate) reductase.
Slovenian: • Pomanjkanje NADPH (nikotinamid adenin dinukleotid fosfat) reduktaze.
English: Too limited data are available to support a continuous infusion dose recommendation.
Slovenian: Za priporočanje odmerka za kontinuirano infuzijo ni na voljo dovolj podatkov.
English: Before any administration, it is recommended to inspect the parenteral solutions to verify that they are free of particles.
Slovenian: Pred dajanjem je priporočljivo pregledati parenteralne raztopine, da bi se prepričali, da ne vsebujejo delcev.
English: Indeed, driving can be affected due to confusional state, dizziness and possibly eye disturbances.
Slovenian: Na vožnjo lahko vpliva zaradi stanja zmedenosti, omotice in morebitnih motenj vida.
English: Keep the ampoule in the original package in order to protect from light.
Slovenian: Ampulo shranjujte v originalni ovojnini za zagotovitev zaščite pred svetlobo.
English: One-month repeated dose toxicity in dogs showed no macroscopic toxic effects.
Slovenian: Toksičnost pri enomesečnih ponavljajočih se odmerkih pri psih ni pokazala makroskopskih toksičnih učinkov.
English: Protective measures against exposure to light should be taken.
Slovenian: Treba se je zaščiti pred izpostavljenostjo svetlobi.
English: Infants above 3 months, children and adolescents: Same posology as for adults.
Slovenian: Dojenčki, starejši od 3 mesecev, otroci in mladostniki: enako odmerjanje kot za odrasle.
English: In rats and rabbits, teratogenic effects have been reported, with foetal and maternal toxicity.
Slovenian: Pri podganah in kuncih so poročali o teratogenih učinkih s toksičnostjo za plod in mater.
English: Both infants had complex medical circumstances and methylthioninium chloride was only partially responsible.
Slovenian: Pri obeh dojenčkih so bile zdravstvene okoliščine zapletene in je bil metiltioninijev klorid samo delno odgovoren.
English: The medicine must be used immediately after opening or dilution.
Slovenian: Zdravilo je treba uporabiti takoj po odprtju ali razredčenju.
English: • Patients with Glucose-6-phosphate dehydrogenase deficiency (G6PD) due to the risk of haemolytic anaemia
Slovenian: • Bolniki s pomanjkanjem glukoza-6-fosfat-dehidrogenaze (G6PD) zaradi tveganja hemolitične anemije.
English: After opening or dilution: From a microbiological point of view, unless the method of opening/dilution precludes the risk of microbial contamination, the product must be used immediately.
Slovenian: Po odprtju ali redčenju: Z mikrobiološkega vidika je treba zdravilo uporabiti takoj, če način odpiranja/redčenja ne preprečuje tveganja mikrobne kontaminacije.
English: Other medicines and Methylthioninium chloride Proveblue Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.
Slovenian: Druga zdravila in zdravilo Metiltioninijev klorid Proveblue Obvestite zdravnika, farmacevta ali medicinsko sestro, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli zdravilo.
English: The majority of the dose is excreted in the urine, usually in the form of leucomethylthioninium chloride.
Slovenian: Večina odmerka se izloči z urinom, običajno v obliki levkometiltioninijevega klorida.
English: There is no experience in patients with severe hepatic impairment.
Slovenian: Pri bolnikih s hudo jetrno okvaro ni izkušenj.
English: If any of the above applies to you, please consult your doctor.
Slovenian: Če karkoli od zgoraj navedenega velja za vas, se posvetujte z zdravnikom.
English: The maximum recommended cumulative dose for the course of treatment is 7 mg/kg.
Slovenian: Najvišji priporočljivi skupni odmerek za celotno zdravljenje je 7 mg/kg.
English: These effects are the same in adults and children except jaundice which has only been reported in infants.
Slovenian: Ti neželeni učinki so enaki pri odraslih in otrocih, razen zlatenice, o kateri so poročali samo pri dojenčkih.
English: The clinical consequences are considered likely to be minimal due to the transient and single dose use that normally occurs in the emergency setting.
Slovenian: Smatra se, da so klinične posledice verjetno minimalne zaradi prehodnega in enkratnega odmerka, ki se običajno uporabi v nujnih okoliščinah.
English: Methylthioninium chloride (also called methylene blue) belongs to a group of medicines called antidotes.
Slovenian: Metiltioninijev klorid (imenovan tudi metilensko modro) spada v skupino zdravil, imenovanih antidoti.
English: Pharmacotherapeutic group: All other therapeutic products, antidotes, ATC code: V03AB17
Slovenian: Farmakoterapevtska skupina: druga nerazvrščena zdravila za zdravljenje različnih bolezni, antidoti, oznaka ATC: V03AB17
English: Reported in infants only
Slovenian: Samo pri dojenčkih
English: Lower doses should therefore be considered and total cumulative dose should not exceed 4 mg/kg.
Slovenian: Zato je treba uporabiti nižje odmerke, kumulativni odmerek pa ne sme preseči 4 mg/kg.
English: Due to a lack of available data on whether methylthioninium chloride passes into human breast milk, breast-feeding should be discontinued for up to 8 days after treatment with this medicine.
Slovenian: Zaradi pomanjkanja razpoložljivih podatkov o tem, ali metiltioninijev klorid prehaja v materino mleko, je treba dojenje prekiniti za 8 dni po zdravljenju s tem zdravilom.
English: Inject very slowly over a period of 5 minutes.
Slovenian: Injicirajte zelo počasi v obdobju 5 minut.
English: Intravenous injection of methylthioninium chloride has occasionally caused hypotension and cardiac arrhythmias, and such disorders might prove fatal on rare occasions.
Slovenian: Intravenska injekcija metiltioninijevega klorida je občasno povzročila hipotenzijo in srčne aritmije, takšne motnje pa so lahko v redkih primerih smrtne.
English: In methaemoglobinaemia, your blood contains too much methaemoglobin (an abnormal form of haemoglobin that is not able to transport oxygen around your body effectively).
Slovenian: Pri methemoglobinemiji vaša kri vsebuje preveč methemoglobina (nenormalne oblike hemoglobina, ki ne more učinkovito prenašati kisika po telesu).
English: Your doctor will inject this medicine into a vein (intravenously) slowly over a period of 5 minutes.
Slovenian: Vaš zdravnik bo to zdravilo počasi v obdobju 5 minut vbrizgal v veno (intravensko).
English: It has also been shown to inhibit the growth of cultured two-cell mouse embryos and the production of progesterone in cultured human luteal cells.
Slovenian: Pokazalo se je tudi, da zavira rast vzgojenih dvoceličnih zarodkov miši in proizvodnjo progesterona pri vzgojenih lutealnih celicah človeka.
English: Patients with hyperglycaemia or diabetes mellitus
Slovenian: Bolniki s hiperglikemijo ali diabetesom mellitusom
English: fluvoxamine, paroxetine, sertraline and zimelidine
Slovenian: fluoksetin, fluvoksamin, paroksetin, sertralin in zimelidin
English: The estimated terminal half-life of methylthioninium chloride after intravenous administration is 26.7h.
Slovenian: Ocenjeni končni razpolovni čas metiltioninijevega klorida po intravenski aplikaciji je 26,7 ur.
English: Methylthioninium chloride Proveblue will be given to you or your child (0-17 years old) to treat problems with your blood resulting from exposure to some medicines or chemicals that can cause a disease called methaemoglobinaemia.
Slovenian: Zdravilo Metiltioninijev klorid Proveblue boste vi ali vaš otrok (0-17 let starosti) prejeli za zdravljenje problemov s krvjo, ki so posledica izpostavljenosti nekaterim zdravilom ali kemikalijam, ki lahko povzročijo bolezen, imenovano methemoglobinemija.
English: Methylthioninium chloride Proveblue is indicated in adults, children and adolescents (aged 0 to 17 years old).
Slovenian: Zdravilo Metiltioninijev klorid Proveblue je indicirano pri odraslih, otrocih in mladostnikih (starih 0 do 17 let).
English: Adverse reactions are the same as in adults (except hyperbilirubinaemia, reported in infants only).
Slovenian: Neželeni učinki so enaki kot pri odraslih (razen hiperbilirubinemije, o kateri so poročali samo pri dojenčkih).
English: It must be injected very slowly over a period of 5 minutes.
Slovenian: Injicirati ga je treba zelo počasi v obdobju 5 minut.
English: Haemolytic anaemia has also been reported in case of severe overdose (20-30 mg/kg) in infants and adults with methaemoglobinaemia caused by aniline or chlorates.
Slovenian: O hemolitični anemiji so poročali tudi v primeru znatno prevelikega odmerjanja (20-30 mg/kg) pri dojenčkih in odraslih z methemoglobinemijo, povzročeno z anilinom ali klorati.
English: There are no adequate data from the use of methylthioninium chloride in pregnant women.
Slovenian: Ni zadostnih podatkov o uporabi metiltioninijevega klorida pri nosečnicah.
English: The efficacy of methylthioninium chloride for the treatment of methaemoglobinaemia in peadiatric population was demonstrated in two retrospective studies and one open randomised clinical trial.
Slovenian: Učinkovitost metiltioninijevega klorida za zdravljenje methemoglobinemije pri pediatrični populaciji je bila dokazana v dveh retrospektivnih študijah in enem odprtem, randomiziranem kliničnem preskušanju.
English: Methylthioninium chloride Proveblue must be injected very slowly over a period of 5 minutes to prevent high local concentrations of the compound from producing additional methaemoglobin.
Slovenian: Zdravilo Metiltioninijev klorid Proveblue je treba injicirati zelo počasi v obdobju 5 minut, da bi preprečili, da visoke lokalne koncentracije spojine povzročijo nastanek dodatnega methemoglobina.
English: Methylthioninium chloride has moderate influence on the ability to drive and use machines.
Slovenian: Metiltioninijev klorid ima zmeren vpliv na sposobnost vožnje in upravljanja strojev.
English: Haemodialysis may be used in patients with severe haemolysis.
Slovenian: Hemodializo se lahko uporabi pri bolnikih s hudo hemolizo.
English: It imparts a blue-green colour to urine, faeces and a blue colour to skin which may hinder a diagnosis of cyanosis.
Slovenian: Povzroči modrozeleno obarvanje urina, blata in modro obarvanje kože, ki lahko ovira diagnosticiranje cianoze.
English: Special care must be taken with Methylthioninium chloride Proveblue: - in newborns and infants 3 months old or younger, lower doses are recommended (see section 3 of this package leaflet).
Slovenian: Bodite posebno pozorni pri uporabi zdravila Metiltioninijev klorid Proveblue: - pri novorojenčkih in dojenčkih, starih 3 mesece ali mlajših, se priporoča nižje odmerke (glejte poglavje 3 teh navodil za uporabo).
English: The excretion of methylthioninium chloride in milk has not been studied in animals.
Slovenian: Izločanje metiltioninijevega klorida v mleko pri živalih ni bilo proučeno.
English: However, if the intravenous use of methylthioninium chloride cannot be avoided, you should be administered the lowest possible dose and observed closely for up to 4 hours after administration.
Slovenian: Če se intravenski uporabi metiltioninijevega klorida ni mogoče izogniti, morate prejeti najnižji možni odmerek in vas je treba do 4 ure po prejemu skrbno spremljati.
English: The clinical consequences are however considered minimal since methylthioninium chloride Proveblue is used often only once and in an acute emergency setting.
Slovenian: Vendar pa se smatra, da so klinične posledice minimalne, saj se zdravilo Metiltioninijev klorid Proveblue pogosto uporabi le enkrat in to v okoliščinah akutne nujnosti.
English: • Selective serotonin reuptake inhibitors (SSRIs) such as citalopram, escitalopram, fluoxetine,
Slovenian: • selektivne zaviralce ponovnega privzema serotonina (SSRI), kot so citalopram, escitalopram,
English: • Common side effects (may affect up to 1 in 10 people): - stomach pain - chest pain - headache - anxiety - injection site pain - vomiting
Slovenian: • Pogosti neželeni učinki (pojavijo se lahko pri največ 1 od 10 bolnikov) - bolečine v želodcu - bolečine v prsih - glavobol - tesnoba - bolečina na mestu injiciranja - bruhanje
English: Adverse reactions, seen at exposure levels similar to clinical exposure levels and with possible relevance to clinical use were moderate regenerative anaemia associated with increased mean platelet count and fibrinogen levels, a minimal increase in mean total bilirubin blood values and an increased incidence of moderate urine bilirubin levels.
Slovenian: Neželeni učinki, ugotovljeni pri stopnjah izpostavljenosti, ki so bile podobne stopnjam klinične izpostavljenosti in z morebitno relevantnostjo za klinično uporabo, so bili zmerna regenerativna anemija, povezana s povečanjem povprečnega števila trombocitov in ravni fibrinogena, majhno povečanje povprečnih vrednosti bilirubina v krvi in povečanje pogostnosti zmernih ravni bilirubina v urinu.
English: Do not drive or use any tools or machines as methylthioninium chloride has moderate influence on the ability to drive and use machines.
Slovenian: Ne vozite avtomobila in ne upravljajte z orodji ali stroji, ker ima metiltioninijev klorid zmeren vpliv na sposobnost upravljanja vozil in strojev.
English: Acute symptomatic treatment of medicinal and chemical products-induced methaemoglobinaemia.
Slovenian: Akutno simptomatsko zdravljenje methemoglobinemije, povzročene z zdravili in kemikalijami.
English: Extreme caution should be exercised when administering to newborns and infants below the age of 3 months due to lower concentrations of NADPH-methaemoglobin reductase necessary for reducing methaemoglobin to haemoglobin, making these infants more susceptible to methaemoglobinaemia produced by high doses of methylthioninium chloride.
Slovenian: Posebna previdnost je potrebna pri dajanju novorojenčkom in dojenčkom, mlajšim od 3 mesecev, zaradi manjših koncentracij NADPH-methemoglobin reduktaze, ki je potrebna za pretvorbo methemoglobina v hemoglobin, zaradi česar so ti dojenčki dovzetnejši za methemoglobinemijo, ki jo povzročijo visoki odmerki metiltioninijevega klorida.
English: These include SSRIs (selective serotonin reuptake inhibitors), bupropion, buspirone, clomipramine, mirtazapine, and venlafaxine.
Slovenian: Ta zdravila vključujejo SSRI (selektivne zaviralce ponovnega privzema serotonina), bupropion, buspiron, klomipramin, mirtazapin in venlafaksin.
English: If you have any doubts about whether this medicine should be given to you, consult your doctor.
Slovenian: Če imate kakršne koli pomisleke glede tega, ali smete prejeti to zdravilo, se posvetujte z zdravnikom.
English: The use of Methylthioninium chloride Proveblue during pregnancy is not recommended unless it is clearly necessary, for example in a life-threatening situation.
Slovenian: Uporaba zdravila Metiltioninijev klorid Proveblue med nosečnostjo ni priporočena, če ni to nujno potrebno, tj. pri življenjsko nevarnem stanju.
English: - if you suffer from hyperglycaemia or diabetes mellitus, as these conditions may be worsened by the glucose solution used for the dilution of the medicine - your urine and stools may turn a blue-green colour; and skin may possibly turn a blue colour when you are treated with Methylthioninium chloride Proveblue.
Slovenian: - če imate hiperglikemijo ali sladkorno bolezen, saj lahko ti bolezni poslabša raztopina glukoze, ki se uporablja za redčenje zdravila - vaš urin in vaše blato se lahko obarvata modrozeleno; koža se lahko pri zdravljenju z zdravilom Metiltioninijev klorid Proveblue obarva modro.
English: If your blood disorder has been caused by aniline or dapsone, total cumulative dose should not exceed 4 mg/kg (see section 2).
Slovenian: Če je vašo bolezen krvi povzročil anilin ali dapson, skupni odmerek ne sme preseči 4 mg/kg (glejte poglavje 2).
English: • mirtazapine
Slovenian: • mirtazapin
English: If the intravenous use of methylthioninium chloride cannot be avoided in patients treated with serotonergic medicinal products, the lowest possible dose should be chosen and the patient observed closely for central nervous system (CNS) effects for up to 4 hours after administration (see sections 4.4 and 4.8).
Slovenian: Če se intravenski uporabi metiltioninijevega klorida pri bolnikih, zdravljenih s serotonergičnimi zdravili, ni mogoče izogniti, je treba izbrati najnižji odmerek in bolnika do 4 ure po aplikaciji skrbno spremljati glede učinkov na osrednje živčevje (glejte poglavji 4.4 in 4.8).
English: You should not be given methylthioninium chloride at the same time you are taking certain medicines to treat depression or anxiety which affect a brain chemical called serotonin.
Slovenian: Metiltioninijevega klorida ne smete prejemati sočasno z določenimi zdravili za zdravljenje depresije ali tesnobe, ki vplivajo na kemikalijo v možganih, imenovano serotonin.
English: If symptoms of serotonin syndrome occur, discontinue use of methylthioninium chloride, and initiate supportive treatment.
Slovenian: Če se pojavijo znaki serotoninskega sindroma, prenehajte z uporabo metiltioninijevega klorida in uvedite podporno zdravljenje.
English: • Hypersensitivity to the active substance, or to any other thiazine dyes
Slovenian: • Preobčutljivost na učinkovino (učinkovine) ali katerokoli tiazinsko barvilo.
English: The clinical consequences of increases plasma concentration of co-administered drugs which are sensitive CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A substrates cannot be ruled out.
Slovenian: Ni mogoče izključiti kliničnih posledic povečanja plazemske koncentracije sočasno uporabljenih učinkovin, ki so občutljivi substrati CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6 in 3A.
English: The adverse reactions listed in the table below occur in adults, children and adolescents (aged 0 to 17 years old) after intravenous administration.
Slovenian: Neželeni učinki, navedeni v spodnji preglednici, poročani pri odraslih, otrocih in mladostnikih (v starosti od 0 do 17 let) po intravenski uporabi.
English: Advise patients to take protective measures against exposure to light, because photosensitivity may occur after administration of methylthioninium chloride.
Slovenian: Bolnikom svetujte, naj se zaščitijo pred izpostavljenostjo svetlobi, saj se lahko po dajanju metiltioninijevega klorida pojavi fotosenzitivnost.
English: Pierrel S.p.A. s.s. Appia 7 bis, 46/48 - 81043 Capua, Italy
Slovenian: s.s. Appia 7 bis, 46/48, 81043 Capua, Italija
English: For instructions on handling and dilution of the medicinal product before administration, see section 6.6.
Slovenian: Za navodila za ravnanje z zdravilom in redčenje pred uporabo glejte poglavje 6.6.
English: Your skin may turn blue - reduction in red blood cells which may turn your skin pale and make you breathless and weak, - jaundice (yellowing of the skin and eyes), this has only been reported in infants.
Slovenian: - zmanjšanje števila rdečih krvnih celic, zaradi česar lahko vaša koža postane bleda ter ste zasopli in slabotni, - zlatenico (porumenelost kože in oči), o čemer so poročali samo pri dojenčkih.
English: • Very common side effects (may affect more than 1 in 10 people) pain in extremity dizziness sweating skin discolouration.
Slovenian: • Zelo pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 10 bolnikov) - bolečina v okončini - omotica - čezmerno potenje - obarvanje kože.
English: Avoid concomitant use of methylthioninium chloride with selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (see section 4.5).
Slovenian: Izogibajte se sočasni uporabi metiltioninijevega klorida s selektivnimi zaviralci ponovnega privzema serotonina (SSRI), zaviralci ponovnega privzema serotonina in noradrenalina (SNRI) in zaviralci monoaminooksidaze (glejte poglavje 4.5).
English: Pierrel S.p.A. s.s. Appia 7 bis, 46/48 IT-81043 Capua (CE) Italy
Slovenian: s.s. Appia 7 bis, 46/48 IT-81043 Capua (CE) Italija
English: Methylthioninium chloride was mutagenic in gene mutation assays in bacteria and mouse lymphoma cells but not in vivo mouse micronucleus assay when administered intravenously at 62 mg/kg.
Slovenian: Metiltioninijev klorid je bil mutagen pri preskušanju genske mutacije bakterij in limfomskih celic miši, vendar ne pri preskušanju mikronukleusa miši in vivo pri intravenski uporabi 62 mg/kg.
English: Methylthioninium chloride is a substrate of P-glycoprotein (P-gp).
Slovenian: Metiltioninijev klorid je substrat P-glikoproteina (P-gp).
English: In the case of aniline- or dapsone-induced methaemaglobinaemia, the maximum recommended cumulative dose for the course of treatment is 4 mg/kg (see section 4.4).
Slovenian: V primeru methemoglobinemije, povzročene z anilinom ali dapsonom, je največji priporočeni kumulativni odmerek za celotno zdravljenje 4 mg/kg (glejte poglavje 4.4).
English: Additional information on how Methylthioninium chloride Proveblue can be given is provided in section 3 of the Package Leaflet.
Slovenian: Dodatne informacije o tem, kako uporabljati zdravilo Metiltioninijev klorid Proveblue, so navedene v poglavju 3 navodil za uporabo.
English: • clomipramine
Slovenian: • klomipramin
English: The maximum recommended cumulative dose for the course of treatment is 7 mg/kg and should not be exceeded, since Methylthioninium chloride administered above the maximum dose may cause methaemoglobinaemia in susceptible patients.
Slovenian: Največji priporočeni kumulativni odmerek v celotnem zdravljenju je 7 mg/kg in se ga ne sme preseči, saj lahko metiltioninijev klorid v količini, ki je večja od največjega odmerka, pri dovzetnih bolnikih povzroči methemoglobinemijo.
English: • Monoamine oxidase inhibitors
Slovenian: • zaviralce monoaminooksidaze
English: 52, Rue Marcel et Jacques Gaucher 94120 Fontenay-sous-Bois France
Slovenian: 52, Rue Marcel et Jacques Gaucher 94120 Fontenay-sous-Bois Francija
English: Some evidence of carcinogenic activity of methylthioniniul chloride has been shown in male mice and male rats.
Slovenian: Obstaja nekaj dokazov o kancerogeni aktivnosti metiltioninijevega klorida pri samcih miši in podgan.