FrancophonIA/ELRC3.0 huggingface dataset:
English: Detailed information on this product is available on the website of the European Medicines Agency (EMA) http://www.ema.europa.eu
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila (EMA) http://www.ema.europa.eu
English: Wilzin treatment should be initiated under the supervision of a physician experienced in the treatment of Wilson's disease (see section 4.4).
Slovenian: Zdravljenje z Wilzinom se mora uvesti pod nadzorom zdravnika, ki je izkušen v zdravljenju Wilsonove bolezni (glejte poglavje 4.4).
English: Pharmacotherapeutic group: various alimentary tract and metabolism products, ATC code: A16AX05.
Slovenian: Farmakoterapevtska skupina: razna zdravila za bolezni prebavil in presnove, Oznaka ATC: A16AX05.
English: Which treatment should be used, zinc or chelating agent should be decided by the physician.
Slovenian: O tem, katero zdravilo naj se uporabi, cink ali kelator, naj odloči zdravnik.
English: For a full list of excipients, see section 6.1.
Slovenian: Za celoten seznam pomožnih snovi glejte poglavje 6.1.
English: The absorption of zinc may be reduced by iron and calcium supplements, tetracyclines and phosphorus-containing compounds, while zinc may reduce the absorption of iron, tetracyclines, fluoroquinolones.
Slovenian: Absorpcijo cinka lahko zmanjšajo dodatki železa in kalcija, tetraciklini in spojine, ki vsebujejo fosfor, medtem ko cink lahko zmanjša absorpcijo železa, tetraciklinov in fluorokinolonov.
English: Patients may present clinically with predominantly hepatic, neurologic, or psychiatric symptoms.
Slovenian: Bolniki lahko klinično kažejo prevladujoče jetrne, nevrološke ali psihiatrične simptome.
English: The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Slovenian: V natisnjenem navodilu za uporabo zdravila morata biti navedena ime in naslov izdelovalca, odgovornega za sprostitev zadevne serije.
English: • Pregnant women:
Slovenian: • Nosečnice:
English: Pharmacological and toxicological data available showed large similarities between zinc salts and among animal species.
Slovenian: Farmakološki in toksikološki podatki, ki so na voljo, kažejo veliko podobnost med posameznimi cinkovimi solmi in med različnimi živalskimi vrstami.
English: • Risk Management Plan (RMP)
Slovenian: • Načrt za obvladovanje tveganj (RMP) Navedba smiselno ni potrebna.
English: Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2)
Slovenian: Izdaja zdravila je le pod omejenimi pogoji in na recept (glejte Dodatek I: Povzetek glavnih značilnosti zdravila, poglavje 4.2)
English: These side effects may occur with certain frequencies, which are defined as follows: • very common:
Slovenian: Do neželenih učinkov lahko pride z določeno pogostostjo, ki je definirana na naslednji način:
English: Dietary copper, which cannot be properly eliminated, accumulates first in the liver, then in other organs such as the eyes and the brain.
Slovenian: Baker iz hrane, ki se ne more pravilno odstraniti iz telesa, se kopiči najprej v jetrih, nato v drugih organih, na primer v očeh in možganih.
English: Dietary fibres and some dairy products, in particular, delay the absorption of zinc salts.
Slovenian: Posebno vlaknine v hrani in nekateri mlečni izdelki odložijo absorpcijo cinkovih soli.
English: This is probably due to some extent of complexion of zinc by the chelator, thus reducing the effect of both active substances.
Slovenian: To je do neke mere verjetno posledica vezave cinka s kelatorjem, s čimer se zmanjša učinek obeh zdravilnih učinkovin.
English: 4.7 Effects on ability to drive and use machines
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji
English: • After Wilzin intake, gastric irritation may occur, especially at the beginning of treatment.
Slovenian: • Po vzetju Wilzina se lahko pojavi draženje želodca, posebno v začetku zdravljenja.
English: As with other anti-copper agents such as penicillamine, your symptoms may get worse after starting the treatment.
Slovenian: Tako kot pri drugih sredstvih proti bakru, na primer pri penicilaminu, se lahko vaši simptomi po začetku zdravljenja poslabšajo.
English: Studies of the co-administration of zinc with food performed in healthy volunteers showed that the absorption of zinc was significantly delayed by many foods (including bread, hard boiled eggs, coffee and milk).
Slovenian: Študije sočasnega jemanja cinka s hrano, opravljene na zdravih prostovoljcih, so pokazale, da so absorpcijo cinka pomembno upočasnile številne vrste hrane (med drugim kruh, trdo kuhana jajca, kava in mleko).
English: Substances in food, especially phytates and fibres, bind zinc and prevent it from entering the intestinal cells.
Slovenian: Snovi v hrani, posebno fitati in vlaknine, vežejo cink in mu preprečujejo vstop v črevesne celice.
English: Bone marrow examination usually reveals characteristic "ringed sideroblasts" (i.e. developing red blood cells containing iron-engorged paranuclear mitochondria).
Slovenian: Preiskava kostnega mozga navadno pokaže značilne “obročaste sideroblaste” (t.j., razvijajoče se rdeče krvničke, ki vsebujejo z železom nabite paranuklearne mitohondrije).
English: Although rare, clinical deterioration may occur at the beginning of the treatment, as has also been reported with chelating agents.
Slovenian: Čeprav je klinično poslabšanje redko, se lahko pojavi v začetku zdravljenja, kot poročajo tudi za kelatorje.
English: If the morning dose is not well tolerated (see section 4) it is possible to delay it to mid-morning, between breakfast and lunch.
Slovenian: Če jutranjega odmerka ne prenašate dobro (glejte poglavje 4), ga lahko odložite na sredino dopoldneva, med zajtrkom in kosilom.
English: Like with all anti-copper agents overtreatment carries the risk of copper deficiency, which is especially harmful for children and pregnant women since copper is required for proper growth and mental development.
Slovenian: Podobno kot pri vseh sredstvih proti bakru preveč intenzivno zdravljenje prinaša nevarnost pomanjkanja bakra, ki je še posebno škodljiva za otroke in nosečnice, ker je baker potreben za pravilno rast in duševni razvoj.
English: Elevations of serum alkaline phosphatase, amylase and lipase may occur after a few weeks of treatment, with levels usually returning to high normal within the first one or two years of treatment.
Slovenian: Po nekaj tednih zdravljenja se lahko pojavi zvišanje serumske alkalne fosfataze, amilaze in lipaze, koncentracije se navadno vrnejo v območje visokih normalnih vrednosti po enem do dveh letih zdravljenja.
English: - This medicine has been prescribed for you personally.
Slovenian: - Zdravilo je bilo predpisano vam osebno in ga ne smete dajati drugim.
English: A daily regimen of 150 mg of Wilzin in three administrations was shown to be effective in significantly reducing copper absorption and inducing a negative copper balance.
Slovenian: Izkazalo se je, da je dnevna shema odmerjanja 150 mg Wilzina v treh razdeljenih odmerkih učinkovita, saj je pomembno zmanjšala absorpcijo bakra in povzročila negativno bilanco bakra.
English: See the package leaflet for further information.
Slovenian: Za nadaljnje informacije glejte navodilo za uporabo.
English: This potentially leads to liver damage and neurological disorders.
Slovenian: To lahko povzroči okvaro jeter in nevrološke bolezni.
English: Since the mechanism of action of zinc is an effect on copper uptake at the level of the intestinal cell, pharmacokinetic evaluations based on blood levels of zinc do not provide useful information on zinc bioavailability at the site of action.
Slovenian: Ker je mehanizem delovanja cinka vpliv na privzem bakra na ravni črevesne celice, farmakokinetične ocene na podlagi koncentracij cinka v krvi ne nudijo koristnih podatkov o biološki uporabnosti cinka na mestu delovanja.
English: The non-ceruloplasmin plasma copper is calculated by subtracting the ceruloplasmin-bound copper from the total plasma copper, given that each milligram of ceruloplasmin contains 3 micrograms of copper.
Slovenian: Neceruloplazminski plazemski baker izračunamo tako, da od celotnega plazemskega bakra odštejemo baker, vezan na ceruloplazmin, pri čemer upoštevamo, da vsak miligram ceruloplazmina vsebuje 3 mikrograme bakra.
English: Laboratory follow-up including haematological surveillance and lipoproteins determination should also be performed in order to detect early manifestations of copper deficiency, such as anaemia and/or leukopenia resulting from bone marrow depression, and decrease in HDL cholesterol and HDL/total cholesterol ratio.
Slovenian: Opravljati je treba tudi kontrolne laboratorijske preiskave, s hematološkim nadzorom in določanjem lipoproteinov vred, da odkrijemo zgodnje znake pomanjkanja bakra, na primer anemijo in/ali levkopenijo, ki sta posledica depresije kostnega mozga, in znižanje HDL holesterola in razmerja HDL/celotni holesterol.
English: • Do not store above 25°C.
Slovenian: • Shranjujte pri temperaturi do 25 °C.
English: Please consult your doctor before taking any other medicines which may reduce the effectiveness of Wilzin, such as iron, calcium supplements, tetracyclines (antibiotics) or phosphorus.
Slovenian: Posvetujte se zdravnikom preden vzamete katerokoli zdravilo, ki bi lahko zmanjšalo učinkovitost zdravila Wilzin, na primer železo, dodatki kalcija, tetraciklini (antibiotiki) ali fosfor.
English: In children who are unable to swallow capsules, these should be opened and their content suspended in a little water (possibly sugar or syrup flavoured water).
Slovenian: Pri otrocih, ki ne morejo požirati kapsul, je treba kapsule odpreti in njihovo vsebino suspendirati v malo vode (ki je lahko oslajena s sladkorjem ali sirupom).
English: However, they must be distinguished from haemolytic anaemia which commonly occurs where there is elevated serum free copper in uncontrolled Wilson's disease.
Slovenian: Razlikovati pa jih moramo od hemolitične anemije, ki se pogosto pojavi, kadar je pri neobvladani Wilsonovi bolezni zvišan prosti baker v serumu.
English: In these patient groups, urinary copper levels should be kept a little above the upper limit of normal or in the high normal range (i.e. 40 - 50 microgram/24 h).
Slovenian: Pri teh skupinah bolnikov naj bodo ravni bakra v urinu vzdrževane malo nad zgornjo mejo normalnih vrednosti ali v visokem delu normalnega območja (t.j., 4050 mikrogramov/24 ur).
English: C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION
Slovenian: C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: Contains E110.
Slovenian: SEZNAM POMOŽNIH SNOVI Vsebuje E110.
English: If you have any further questions on the use of this medicine, ask your doctor.
Slovenian: Za morebitna nadaljnja vprašanja o uporabi tega zdravila se obrnite na svojega zdravnika.
English: 6.1 List of excipients Capsule content maize starch magnesium stearate
Slovenian: 6.1 Seznam pomožnih snovi Vsebina kapsule koruzni škrob magnezijev stearat
English: They may be early manifestations of copper deficiency and may recover rapidly following reduction of zinc dosage.
Slovenian: Ti utegnejo biti zgodnji znak pomanjkanja bakra in se utegnejo po zmanjšanju odmerjanja cinka hitro popraviti.
English: Animal studies conducted with different zinc salts do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Slovenian: Študije na živalih, opravljene z različnimi cinkovimi solmi, niso pokazale neposrednih ali posrednih škodljivih vplivov na nosečnost, razvoj zarodka/plodu, porod ali postnatalni razvoj (glejte poglavje
English: 5.3 Preclinical safety data
Slovenian: 5.3 Predklinični podatki o varnosti
English: In this case you must ask your doctor for advice.
Slovenian: V tem primeru prosite za nasvet zdravnika.
English: It is very important to continue anti-copper therapy during pregnancy.
Slovenian: Zelo pomembno je, da med nosečnostjo še naprej jemljete zdravilo proti bakru.
English: Two patients of a series of 16 died from hepatic decompensation and advanced portal hypertension after being changed from penicillamine to zinc therapy.
Slovenian: Dva bolnika iz skupine 16 bolnikov sta umrla zaradi dekompenzacije jeter in napredovale portalne hipertenzije, potem ko sta prešla s penicilamina na zdravljenje s cinkom.
English: It is also possible to take Wilzin with a little protein, such as meat (see section 4.5).
Slovenian: Wilzin se lahko vzame tudi z malo beljakovin, na primer mesa (glejte poglavje 4.5).
English: • Periodic Safety Update Reports
Slovenian: • Redno posodobljena poročila o varnosti zdravila (PSUR)
English: Do not store above 25°C.
Slovenian: Shranjujte pri temperaturi do 25 °C.
English: If you have been prescribed Wilzin with another anti-copper agent, such as penicillamine, keep an interval of at least 1 hour between the two medicines.
Slovenian: Če so vam Wilzin predpisali skupaj z drugim sredstvom proti bakru, na primer s penicilaminom, pazite, da bo presledek med obema zdraviloma vsaj 1 ura.
English: 6.5 Nature and contents of container
Slovenian: 6.5 Vrsta ovojnine in vsebina
English: If you are currently treated with another anti-copper agent, for example, penicillamine, your doctor may add Wilzin before stopping the initial treatment.
Slovenian: Če se trenutno zdravite z drugim sredstvom proti bakru, na primer s penicilaminom, vam bo mogoče zdravnik dodal Wilzin, še preden vam bo ukinil začetno zdravljenje.
English: Investigations common:
Slovenian: Preiskave pogosti:
English: Always take Wilzin on an empty stomach, at least one hour before or 2-3 hours after meals.
Slovenian: Wilzin vedno vzemite na prazen želodec, vsaj 1 uro pred obroki ali 2-3 ure po obrokih.
English: Therefore, breast-feeding should be avoided during Wilzin therapy.
Slovenian: Zato se je treba dojenju med zdravljenjem z Wilzinom izogibati.
English: As copper deficiency may also cause myeloneuropathy, physicians should be alert to sensory and motor symptoms and signs which may potentially indicate incipient neuropathy or myelopathy in patients treated with Wilzin.
Slovenian: Ker lahko pomanjkanje bakra povzroči mielonevropatijo, morajo biti zdravniki pozorni na senzorične in motorične simptome ter znake, ki bi lahko kazali na začetke nevropatije ali mielopatije pri bolnikih, ki se zdravijo z zdravilom Wilzin.
English: The most common undesirable effect is gastric irritation.
Slovenian: Najpogostejši neželeni učinek je draženje želodca.
English: It is available in packs of 250 hard capsules in a polyethylene bottle closed by a polypropylene and polyethylene closure.
Slovenian: Na voljo je v zloženkah s po 250 trdimi kapsulami v polietilenski plastenki, zaprti s pokrovčkom iz polipropilena in polietilena.
English: Data on a limited number of exposed pregnancies in patients with Wilson's disease give no indication of harmful effects of zinc on embryo/foetus and mother.
Slovenian: Podatki, zbrani pri omejenem številu izpostavljenih nosečnosti pri bolnicah z Wilsonovo boleznijo ne kažejo na možnost škodljivih vplivov cinka na zarodek/plod in mater.
English: Date of latest renewal: 13 October 2009
Slovenian: Datum zadnjega podaljšanja dovoljenja za promet: 13 oktober 2009
English: Symptomatic patients must be initially treated with a chelating agent; once copper levels are below toxic thresholds and patients are clinically stable, maintenance treatment with Wilzin can be considered.
Slovenian: Simptomatske bolnike je treba v začetku zdraviti z enim od kelatorjev; ko koncentracije bakra padejo pod prag toksičnosti in se bolniki klinično stabilizirajo, pride v poštev vzdrževalno zdravljenje z Wilzinom.
English: The plasma elimination half-life of zinc in healthy subjects is around 1 hour after a dose of 45 mg.
Slovenian: Razpolovni čas odstranjevanja cinka iz plazme je pri zdravih osebah po odmerku 45 mg okrog 1 ura.
English: The weight of evidence, from in vitro and in vivo tests, suggests that zinc has no clinically relevant genotoxic activity.
Slovenian: Teža dokaznega materiala iz testov in vitro in in vivo kaže, da cink nima klinično pomembne genotoksične aktivnosti.
English: Wilzin must be taken on an empty stomach, at least 1 hour before or 2-3 hours after meals.
Slovenian: Wilzin je treba jemati na prazen želodec, vsaj 1 uro pred obroki ali 2-3 ure po obrokih.
English: To administer Wilzin to children who are unable to swallow capsules, open the capsule and mix the powder with a little water (possibly flavoured with sugar or syrup).
Slovenian: Wilzin date otroku, ki ne more pogoltniti kapsule, tako, da kapsulo odprete in prašek zmešate z malo vode (mogoče oslajene s sladkorjem ali sirupom).
English: 4.9 Overdose
Slovenian: 4.9 Preveliko odmerjanje
English: The aim of the treatment is to maintain the plasma free copper (also known as non-ceruloplasmin plasma copper) below 250 microgram/l (normal: 100-150 microgram/l) and the urinary copper excretion below 125 microgram/24 h (normal: < 50 microgram/24 h).
Slovenian: Cilj zdravljenja je vzdrževanje koncentracije prostega bakra v plazmi (ki je znan tudi kot neceruloplazminski plazemski baker) pod 250 mikrogramov/l (normalna koncentracija: 100-150 mikrogramov/l) in izločanje bakra z urinom pod 125 mikrogrami/24 ur (normalno: < 50 mikrogramov/24 ur).
English: Hypersensitivity to the active substance or to any of the excipients.
Slovenian: Preobčutljivost za zdravilno učinkovino ali katerokoli pomožno snov.
English: In treated patients, assays of urinary and/or plasma zinc may be a useful measure of treatment compliance.
Slovenian: Pri zdravljenih bolnikih je lahko določanje cinka v urinu in/ali plazmi koristno merilo tega, koliko se bolniki držijo navodil za zdravljenje.
English: Recordati Rare Diseases Eco River Parc 30, rue des Peupliers F-92000 Nanterre France
Slovenian: Recordati Rare Diseases Eco River Parc 30, rue des Peupliers F-92000 Nanterre Francija
English: What Wilzin is and what it is used for Before you take Wilzin How to take Wilzin Possible side effects 5 How to store Wilzin Further information
Slovenian: Kaj je zdravilo Wilzin in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Wilzin Kako jemati zdravilo Wilzin Možni neželeni učinki
English: blood amylase, lipase and alkaline phosphatase increased
Slovenian: zvišanje amilaze, lipaze in alkalne fosfataze v krvi
English: Death occurred in a 35 year-old woman on the fifth day after ingestion of 6 g of zinc (40 times the proposed therapeutic dose) and was attributed to renal failure and haemorrhagic pancreatitis with hyperglycaemic coma.
Slovenian: Petintridesetletna ženska je umrla petega dne po zaužitju 6 g cinka (40-kratni predlagani terapevtski odmerek), smrt so pripisali ledvični odpovedi in hemoragičnemu pankreatitisu s hiperglikemično komo.
English: It may also be minimised by taking the first dose of Wilzin with a small amount of protein-containing food, such as meat (but not milk).
Slovenian: Še bolj ga lahko zmanjšate tako, da vzamete prvi odmerek Wilzina z majhno količino beljakovinske hrane, na primer z mesom (ne pa z mlekom).
English: This side effect may be reduced by postponing the first dose of the day until mid-morning (between breakfast and the midday meal).
Slovenian: Ta neželeni učinek lahko zmanjšate tako, da odložite prvi dnevni odmerek na sredino dopoldneva (med zajtrkom in kosilom).
English: What Wilzin looks like and contents of the pack
Slovenian: Izgled zdravila Wilzin in vsebina pakiranja
English: The oral LD50 is approximately 300 mg zinc/kg body weight (about 100 to 150 times the human therapeutic dose).
Slovenian: Peroralna LD50 je približno 300 mg cinka/kg telesne teže (okrog 100 do 150-krat več od terapevtskega odmerka za človeka).
English: Unabsorbed copper is then eliminated in the stool.
Slovenian: Neabsorbirani baker se nato izloči v blatu.
English: White HDPE bottle with a polypropylene and HDPE closure and contains a filler (cotton coil).
Slovenian: Plastenka iz belega HDPE s pokrovčkom iz polipropilena in HDPE in vsebuje polnilo (zvitek vate).
English: Important information about some of the ingredients of Wilzin Wilzin 50 mg hard capsules contains sunset yellow FCF (E110) which may cause allergic reactions.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Wilzin Wilzin 50 mg trde kapsule vsebujejo sončno rumeno FCF (E110), ki lahko povzroča alergijske reakcije.
English: Reporting of suspected adverse reactions
Slovenian: Poročanje o domnevnih neželenih učinkih
English: Heavy metal chelation therapy should be considered if plasma zinc levels are markedly elevated (> 10 mg/l).
Slovenian: Zdravljenje s keliranjem težkih kovin pride v poštev, če je koncentracija cinka v plazmi močno zvišana (> 10 mg/l).
English: Treatment of overdose should be with gastric lavage or induced emesis as quickly as possible to remove unabsorbed zinc.
Slovenian: Preveliko odmerjanje je treba zdraviti s čimprejšnjim izpiranjem želodca ali umetno sproženim bruhanjem, da odstranimo neabsorbirani cink.
English: Manufacturer
Slovenian: Izdelovalec
English: The bottle also contains a cotton filler.
Slovenian: Plastenka vsebuje tudi polnilo iz vate.
English: Repeat-dose toxicity studies have established that the NOEL (No Observed Effect Level) is about 95 mg zinc/kg body weight (about 48 times the human therapeutic dose).
Slovenian: Študije toksičnosti ponavljajočih se odmerkov so pokazale, da je NOEL (raven, pri kateri ni opaznega učinka) okrog 95 mg cinka/kg telesne teže (okrog 48-krat več od terapevtskega odmerka za človeka).
English: The capsule shell contains sunset yellow FCF (E110), which may cause allergic reactions.
Slovenian: Ovojnica kapsule vsebuje sončno rumeno FCF (E110), ki lahko povzroča alergijske reakcije.
English: For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.
Slovenian: Za vse morebitne nadaljnje informacije o tem zdravilu se lahko obrnete na predstavništvo imetnika dovoljenja za promet z zdravilom.
English: Urinary copper levels are usually increased with chelation therapy such as penicillamine or trientine.
Slovenian: Raven bakra v urinu se pri zdravljenju s kelatorji, na primer s penicilaminom ali trientinom, navadno zviša.
English: Another adolescent who ingested 4 g of zinc had serum zinc level of about 50 mg/l 5 hours later and only experienced severe nausea, vomiting and dizziness.
Slovenian: Drug mladostnik, ki je zaužil 4 g cinka, je imel 5 ur pozneje koncentracijo cinka v serumu okrog 50 mg/l, od simptomov in znakov pa samo hudo navzeo, bruhanje in vrtoglavost.
English: Pharmacodynamic studies were conducted in Wilson's disease patients on the combination of Wilzin (50 mg three times daily) with ascorbic acid (1 g once daily), penicillamine (250 mg four times daily), and trientine (250 mg four times daily).
Slovenian: Pri bolnikih z Wilsonovo boleznijo so opravili farmakodinamične študije kombinacije Wilzina (50 mg trikrat na dan) z askorbinsko kislino (1 g enkrat na dan), penicilamina (250 mg štirikrat na dan), in trientina (250 mg štirikrat na dan).
English: The urinary excretion of copper is an accurate reflection of body loading with excess copper only when patients are not on chelation therapy.
Slovenian: Izločanje bakra z urinom je natančen odsev obremenitve telesa z odvečnim bakrom samo takrat, ko se bolniki ne zdravijo s kelatorji.
English: Reported adverse reactions are listed below, by system organ class and by frequency.
Slovenian: Neželeni učinki, o katerih poročajo, so navedeni spodaj po organskih sistemih in po pogostosti.
English: In all cases, dose should be adjusted according to therapeutic monitoring (see section 4.4.
Slovenian: V vseh primerih je treba odmerek prilagoditi glede na terapevtsko spremljanje (glejte poglavje 4.4).
English: PHARMACEUTICAL FORM AND CONTENTS
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA
English: The level of hepatic copper cannot be used to manage therapy since it does not differentiate between potentially toxic free copper and metallothionein bound copper.
Slovenian: Raven bakra v jetrih ni uporabna za uravnavanje zdravljenja, ker ne razlikuje med potencialno toksičnim prostim bakrom in bakrom, vezanim na metalotionein.