FrancophonIA/ELRC3.0 huggingface dataset:
English: The reconstituted solution is clear and ranges in colour from colourless to yellow or green-yellow without adversely affecting product quality.
Croatian: Rekonstituirana otopina je bistra i u rasponu boja od bezbojne do žute ili zeleno-žute, što ne utječe nepovoljno na kvalitetu lijeka.
English: Superio rity pvalue pemetrexed + cisplatin gemcitabine + cisplatin
Croatian: pvrijedno sti za superior nost pemetreksed + cisplatin gemcitabin + cisplatin
English: Pemetrexed can have genetically damaging effects.
Croatian: Pemetreksed može izazvati oštećenja gena.
English: Patients with renal impairment (Standard Cockcroft and Gault formula or glomerular filtration rate measured Tc99m DPTA serum clearance method)
Croatian: Bolesnici s oštećenjem bubrega (serumski klirens izračunat standardnom Cockcroftovom i Gaultovom formulom ili metodom mjerenja stope glomerularne filtracije Tc99m-DPTA)
English: Safety was assessed for patients who were randomised to receive pemetrexed (N=800).
Croatian: Napravljena je procjena sigurnosti u bolesnika randomiziranih da primaju pemetreksed (N=800).
English: You will always receive Pemetrexed Pfizer by infusion into one of your veins.
Croatian: Lijek Pemetreksed Pfizer uvijek ćete primiti infuzijom u jednu od vena.
English: The dose of Pemetrexed Pfizer is 500 milligrams for every square metre of your body's surface area.
Croatian: Doza lijeka Pemetreksed Pfizer je 500 miligrama po svakom kvadratnom metru Vaše površine tijela.
English: If you have an accumulation of fluid around your lungs, your doctor may decide to remove the fluid before giving you Pemetrexed Pfizer.
Croatian: Ako imate nakupljenu tekućinu oko pluća, liječnik može odlučiti ukloniti tu tekućinu prije primjene lijeka Pemetreksed Pfizer.
English: If concomitant administration of NSAIDs is necessary, patients should be monitored closely for toxicity, especially myelosuppression and gastrointestinal toxicity.
Croatian: Ako je istodobna primjena NSAIL-a nužna, bolesnici se moraju pažljivo nadzirati kako bi se uočili eventualni znakovi toksičnosti, naročito mijelosupresije i gastrointestinalne toksičnosti.
English: The corticosteroid should be equivalent to 4 mg of dexamethasone administered orally twice a day (see section 4.4).
Croatian: Doza kortikosteroida mora biti ekvivalentna dozi od 4 mg deksametazona primijenjenog peroralno dvaput na dan (vidjeti dio 4.4).
English: Pre-treatment with dexamethasone (or equivalent) can reduce the incidence and severity of skin reactions (see section
Croatian: Prethodnim davanjem deksametazona (ili ekvivalentnog lijeka) mogu se smanjiti incidencija i težina kožnih reakcija (vidjeti dio 4.2).
English: The high intra-individual variability of the coagulation status during diseases and the possibility of interaction between oral anticoagulants and anti-cancer chemotherapy require increased frequency of INR (International Normalised Ratio) monitoring, if it is decided to treat the patient with oral anticoagulants.
Croatian: S obzirom na veliku intraindividualnu varijabilnost koagulacijskog statusa tijekom bolesti i mogućnost interakcije između peroralnih antikoagulansa i antitumorske kemoterapije, nužno je češće praćenje INR-a (internacionalnog normaliziranog omjera) ako se bolesnika odluči liječiti peroralnim antikoagulansima.
English: Pemetrexed total systemic clearance is 91.8 ml/min and the elimination half-life from plasma is 3.5 hours in patients with normal renal function (creatinine clearance of 90 ml/min).
Croatian: Ukupni sistemski klirens pemetrekseda iznosi 91,8 ml/min, a poluvrijeme eliminacije iz plazme iznosi 3,5 sati u bolesnika s normalnom bubrežnom funkcijom (klirens kreatinina 90 ml/min).
English: Patients must also receive an intramuscular injection of vitamin B12 (1,000 micrograms) in the week preceding the first dose of pemetrexed and once every three cycles thereafter.
Croatian: Bolesnici moraju također primiti i intramuskularnu injekciju vitamina B12 (1000 mikrograma) u tjednu prije prve doze pemetrekseda te nakon toga jedanput svaka tri ciklusa.
English: To reduce toxicity, patients treated with pemetrexed must also receive vitamin supplementation (see section 4.4).
Croatian: Kako bi se smanjila toksičnost, bolesnici koji se liječe pemetreksedom moraju primati i vitaminsku nadoknadu (vidjeti dio 4.4).
English: It must be administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Croatian: Mora se primjenjivati u obliku intravenske infuzije u trajanju od 10 minuta prvog dana svakog 21-dnevnog ciklusa.
English: Any Grade 3 or 4 toxicities except mucositis
Croatian: Bilo koja toksičnost stupnja 3 ili 4 osim mukozitisa
English: Clinically relevant toxicities with respect to gender were similar to the overall population in patients receiving pemetrexed plus cisplatin.
Croatian: Klinički značajne toksičnosti s obzirom na spol bile su podjednake u cjelokupnoj populaciji bolesnika koji su primali pemetreksed i cisplatin.
English: • Fever or infection (common): if you have a temperature of 38ºC or greater, sweating or other signs of infection (since you might have less white blood cells than normal which is very common).
Croatian: • vrućicu ili infekciju (često): ako Vam je tjelesna temperatura 38°C ili viša, ako se znojite ili imate neke druge znakove infekcije (jer broj bijelih krvnih stanica može biti manji od normalnog, što je vrlo česta pojava).
English: A significant increase in the incidence of possibly study-medicinal product-related Grade 3/4 neutropenia was observed with longer exposure to pemetrexed (≤6 cycles: 3.3%, >6 cycles: 6.4%: p=0.046).
Croatian: Zabilježeno je značajno povećanje incidencije neutropenije stupnja 3/4, koja je mogla biti povezana s lijekom, pri duljoj izloženosti pemetreksedu (≤ 6 ciklusa: 3,3%, > 6 ciklusa: 6,4%; p = 0,046).
English: All patients included in this study had an ECOG performance status 0 or 1.
Croatian: Svi bolesnici koji su uključeni u ovo ispitivanje imali su ECOG izvedbeni status 0 ili 1.
English: Pemetrexed Pfizer is a medicine used in the treatment of cancer.
Croatian: Pemetreksed Pfizer je lijek koji se koristi za liječenje raka.
English: Do not use this medicine after the expiry date which is stated on the carton and label after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i naljepnici iza oznake Rok valjanosti ili EXP.
English: Treatment should be resumed according to the guidelines in Table 2.
Croatian: Potom se liječenje može nastaviti prema smjernicama u Tablici 2.
English: Prior to each chemotherapy administration, blood chemistry tests should be collected to evaluate renal and hepatic function.
Croatian: Prije svake kemoterapije moraju se provesti laboratorijske krvne pretrage kako bi se ocijenila funkcija bubrega i jetre.
English: Pemetrexed Pfizer must only be reconstituted with sterile water for injections.
Croatian: Pemetreksed Pfizer smije se rekonstituirati samo sa sterilnom vodom za injekcije.
English: Kaplan-Meier plots of overall survival by histology
Croatian: Kaplan Meierove krivulje ukupnog preživljenja prema histološkom tipu tumora
English: The analysis of the impact of NSCLC histology on overall survival demonstrated clinically relevant differences in survival according to histology, see table below.
Croatian: Analiza utjecaja histologije NSCLC-a na ukupno preživljenje pokazala je klinički značajnu razliku u preživljenju s obzirom na histološki tip tumora; vidjeti tablicu ispod.
English: Rare cases of anaphylactic shock have been reported.
Croatian: Prijavljeni su rijetki slučajevi anafilaktičkog šoka.
English: 75% of previous dose
Croatian: 75% prethodne doze
English: The polyglutamate forms are retained in cells and are even more potent inhibitors of TS and GARFT.
Croatian: Poliglutamatni oblici ostaju u stanici i još potentnije inhibiraju TS i GARFT.
English: If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive Pemetrexed Pfizer.
Croatian: Ako trenutno imate ili ste prethodno imali problema s bubrezima, obratite se svom liječniku ili bolničkom ljekarniku jer možda nećete smjeti primati lijek Pemetreksed Pfizer.
English: 2D barcode carrying the unique identifier included
Croatian: Sadrži 2D barkod s jedinstvenim identifikatorom.
English: No relationships between AST (SGOT), ALT (SGPT), or total bilirubin and pemetrexed pharmacokinetics were identified.
Croatian: Nije utvrđen odnos između vrijednosti AST-a (SGOT-a), ALT-a (SGPT-a) odnosno ukupnog bilirubina i farmakokinetike pemetrekseda.
English: UNIQUE IDENTIFIER- HUMAN READABLE DATA PC:
Croatian: JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM
English: A total of 169 patients (47.1%) completed ≥ 6 cycles maintenance treatment with pemetrexed, representing at least 10 total cycles of pemetrexed.
Croatian: Ukupno je 169 (47,1%) bolesnika završilo ≥ 6 ciklusa terapije održavanja pemetreksedom, što znači da su primili najmanje 10 ciklusa pemetrekseda.
English: An updated RMP should be submitted: • At the request of the European Medicines Agency;
Croatian: • na zahtjev Europske agencije za lijekove;
English: Of the 939 patients treated with pemetrexed plus cisplatin induction, 539 patients were randomised to maintenance treatment with pemetrexed or placebo.
Croatian: Od 939 bolesnika liječenih uvodnom terapijom pemetreksedom i cisplatinom, 539 bolesnika randomizirano je u skupinu koja je primala terapiju održavanja pemetreksedom ili placebo.
English: Uncommon cases of peripheral ischaemia leading sometimes to extremity necrosis have been reported.
Croatian: Prijavljeni su manje česti slučajevi periferne ishemije koja je ponekad dovela do nekroze ekstremiteta.
English: Thus, drainage of third-space fluid collection prior to pemetrexed treatment should be considered, but may not be necessary.
Croatian: Stoga je prije početka liječenja pemetreksedom potrebno razmotriti drenažu tekućine iz transcelularnog prostora, no ona možda neće biti nužna.
English: Concomitant yellow fever vaccine (see section 4.5).
Croatian: Istodobno cijepljenje cjepivom protiv žute groznice (vidjeti dio 4.5).
English: Corticosteriods: your doctor will prescribe you steroid tablets (equivalent to 4 milligram of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after Pemetrexed Pfizer treatment.
Croatian: Kortikosteroidi: liječnik će Vam propisati tablete kortikosteroida (ekvivalentne dozi deksametazona od 4 mg dvaput na dan) koje ćete morati uzeti dan prije, na sam dan i dan nakon primjene lijeka Pemetreksed Pfizer.
English: If you have heart disease or a history of heart disease, please tell your doctor.
Croatian: Ako bolujete ili ste ranije bolovali od srčane bolesti, obavijestite o tome svog liječnika.
English: Use an inactivated vaccine where it exists (poliomyelitis) (see section 4.4).
Croatian: Treba koristiti inaktivirano cjepivo, ako postoji (poliomijelitis) (vidjeti dio 4.4).
English: The pemetrexed maintenance safety profiles from the two studies JMEN and PARAMOUNT were similar.
Croatian: Sigurnosni profili terapije održavanja pemetreksedom bili su podjednaki u ispitivanjima JMEN i PARAMOUNT.
English: No statistically significant differences in any other individual Grade 3/4/5 adverse reactions were seen with longer exposure.
Croatian: Nisu uočene statistički značajne razlike između skupina za bilo koju drugu pojedinačnu nuspojavu stupnjeva 3/4/5 pri duljoj izloženosti lijeku.
English: In the event of suspected overdose, patients should be monitored with blood counts and should receive supportive therapy as necessary.
Croatian: Posumnja li se na predoziranje, treba pratiti krvnu sliku bolesnika i, prema potrebi, provesti potporno liječenje.
English: Use in combination with cisplatin
Croatian: Primjena u kombinaciji s cisplatinom
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti, nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
English: Owing to the possibility of pemetrexed treatment causing irreversible infertility (see section 5.3), men are advised to seek counselling on sperm storage before starting treatment.
Croatian: Budući da liječenje pemetreksedom može uzrokovati trajnu neplodnost (vidjeti dio 5.3), muškarcima se preporučuje da prije početka liječenja potraže savjet o pohrani sperme.
English: Reconstituted and infusion solutions: When prepared as directed, chemical and physical in-use stability has been demonstrated for 24 hours at refrigerated temperature (2°C to 8°C) and at 25°C.
Croatian: Rekonstituirana otopina i otopina za infuziju: kada se pripreme prema uputama, fizikalno i kemijski su stabilne 24 sata ako se čuvaju u hladnjaku (2°C do 8°C) i na temperaturi od 25°C .
English: Patients received a median of 4 cycles of maintenance treatment with pemetrexed and 4 cycles of placebo.
Croatian: Bolesnici su primili medijan od 4 ciklusa terapije održavanja pemetreksedom i 4 ciklusa placeba.
English: Of the randomised patients, 44.9% had a complete/partial response and 51.9% had a response of stable disease to pemetrexed plus cisplatin induction.
Croatian: Od svih randomiziranih bolesnika njih je 44,9% imalo kompletan/djelomičan odgovor na uvodno liječenje pemetreksedom u kombinaciji s cisplatinom, a 51,9% njih odgovor u obliku stabilne bolesti.
English: Polyglutamation is a time- and concentration-dependent process that occurs in tumour cells and, to a lesser extent, in normal tissues.
Croatian: Stvaranje poliglutamata je proces ovisan o vremenu i koncentraciji, koji se odvija u tumorskim stanicama i, u manjoj mjeri, u zdravim tkivima.
English: Pemetrexed Pfizer can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Croatian: Pemetreksed Pfizer Vam se može propisati ako imate rak pluća u uznapredovaloj fazi i ako je Vaša bolest reagirala na liječenje ili ostala uglavnom nepromijenjena nakon početne kemoterapije.
English: In a study conducted in beagle dog by intravenous bolus injection for 9 months, testicular findings (degeneration/necrosis of the seminiferous epithelium) have been observed.
Croatian: U ispitivanju provedenom u pasa pasmine bigl, kojima su davane intravenske bolusne injekcije tijekom devet mjeseci, opažene su promjene na testisima (degeneracija/nekroza sjemenovodnog epitela).
English: Therefore, the use of pemetrexed in patients with creatinine clearance of <45 ml/min is not recommended (see section 4.2).
Croatian: Stoga se primjena pemetrekseda u bolesnika s klirensom kreatinina < 45 ml/min ne preporučuje (vidjeti dio 4.2).
English: There are many sorts of NSAIDs with different durations of activity.
Croatian: Postoje brojne vrste nesteroidnih protuupalnih lijekova s različitim trajanjem djelovanja.
English: Pemetrexed is mainly eliminated unchanged renally by tubular secretion and to a lesser extent by glomerular filtration.
Croatian: Pemetreksed se uglavnom eliminira u nepromijenjenu obliku putem bubrega, tubularnom sekrecijom i u manjoj mjeri glomerularnom filtracijom.
English: Your doctor may decide to change the dose or delay treating you depending on your general condition and if your blood cell counts are too low.
Croatian: Liječnik može promijeniti dozu ili odgoditi liječenje ovisno o Vašem općem stanju i u slučaju da je broj krvnih stanica prenizak.
English: Prior chemotherapy did not include pemetrexed.
Croatian: Prethodna kemoterapija nije uključivala pemetreksed.
English: First-line doublet therapy containing pemetrexed was not included.
Croatian: Nije bila uključena prva linija dvojne terapije koja je sadržavala pemetreksed.
English: The 1 year and 2 year survival rates for patients on pemetrexed were 58% and 32% respectively, compared to 45% and 21% for patients on placebo.
Croatian: Za bolesnike liječene pemetrekseom stopa jednogodišnjeg preživljenja iznosila je 58%, a stopa dvogodišnjeg preživljenja 32%, u usporedbi s 45% odnosno 21% za bolesnike koji su primali placebo.
English: You must continue taking the folic acid for 21 days after the last dose of Pemetrexed Pfizer.
Croatian: Morate nastaviti uzimati folatnu kiselinu još najmanje 21 dan nakon posljednje doze lijeka Pemetreksed Pfizer.
English: Therefore, caution should be made when administering higher doses of NSAIDs or acetylsalicylic acid, concurrently with pemetrexed to patients with normal function (creatinine clearance ≥ 80 ml/min).
Croatian: Stoga je nužan oprez pri istodobnoj primjeni pemetrekseda i viših doza NSAIL-a ili acetilsalicilatne kiseline u bolesnika s normalnom bubrežnom funkcijom (klirens kreatinina ≥ 80 ml/min).
English: Concomitant use not recommended
Croatian: Ne preporučuje se istodobna primjena
English: Calculate the dose and the number of Pemetrexed Pfizer vials needed.
Croatian: Izračunajte dozu i potreban broj bočica lijeka Pemetreksed Pfizer.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would not be longer than 24 hours at 2°C to 8°C.
Croatian: Ako se ne primijeni odmah, vrijeme i uvjeti čuvanja lijeka prije primjene odgovornost su korisnika i ne bi trebali biti dulji od 24 sata na temperaturi od 2°C do 8°C.
English: Patients received a median of 5 cycles of maintenance treatment with pemetrexed and 3.5 cycles of placebo.
Croatian: Bolesnici su primili medijan od 5 ciklusa terapije održavanja pemetreksedom i 3,5 ciklusa placeba.
English: This medicine is for single use only; any unused solution must be disposed of in accordance with local requirement.
Croatian: Lijek je isključivo za jednokratnu primjenu; neiskorištenu otopinu potrebno je zbrinuti sukladno nacionalnim propisima.
English: The doctor or hospital pharmacist will work out the dose you need based on your height and weight.
Croatian: Liječnik ili bolnički ljekarnik odredit će potrebnu dozu na temelju
English: Treatment with pemetrexed should be discontinued if a patient experiences any haematologic or nonhaematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed.
Croatian: Liječenje pemetreksedom se mora prekinuti ako se u bolesnika pojavi bilo kakva hematološka ili nehematološka toksičnost stupnja 3 ili 4 nakon dvaju sniženja doze, odnosno odmah ako se ustanovi neurotoksičnost stupnja 3 ili 4.
English: Patients should discontinue therapy if Grade 3 or 4 neurotoxicity is observed.
Croatian: Liječenje se mora prekinuti ako se ustanovi neurotoksičnost stupnja 3 ili 4.
English: Use aseptic technique during the reconstitution and further dilution of pemetrexed for intravenous infusion administration.
Croatian: Koristite aseptičku tehniku kod rekonstitucije i daljnjeg razrjeđivanja pemetrekseda za primjenu u intravenskoj infuziji.
English: Side effects with pemetrexed may include:
Croatian: Moguće nuspojave pemetrekseda su:
English: It is not known whether pemetrexed is excreted in human milk, and adverse reactions on the breast-feeding child cannot be excluded.
Croatian: Nije poznato izlučuje li se pemetreksed u majčino mlijeko pa se ne mogu isključiti nuspojave na dojenče.
English: Other medicines and Pemetrexed Pfizer
Croatian: Drugi lijekovi i Pemetreksed Pfizer
English: Discard unused contents appropriately
Croatian: Neiskorišteni sadržaj zbrinite na odgovarajući način
English: Rarely seen events include Stevens-Johnson syndrome and toxic epidermal necrolysis.
Croatian: Među rijetko zabilježene događaje ubrajaju se Stevens-Johnsonov sindrom i toksična epidermalna nekroliza.
English: Patients must take oral folic acid or a multivitamin containing folic acid (350 to 1,000 micrograms) on a daily basis.
Croatian: Bolesnici moraju svakodnevno peroralno uzimati folatnu kiselinu ili multivitaminski pripravak koji sadrži folatnu kiselinu (350 do 1000 mikrograma).
English: There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore, the use of pemetrexed is not recommended (see section 4.4).
Croatian: Nema dovoljno podataka o primjeni pemetrekseda u bolesnika s klirensom kreatinina manjim od 45 ml/min; stoga se u tih bolesnika ne preporučuje primjena pemetrekseda (vidjeti dio 4.4).
English: What you need to know before you use Pemetrexed Pfizer
Croatian: Što morate znati prije nego počnete primati Pemetreksed Pfizer
English: ***Integrated adverse reactions table combines the results of the JMEN pemetrexed maintenance (N=663) and PARAMOUNT continuation pemetrexed maintenance (N=539) studies.
Croatian: ***Integrirana tablica nuspojava objedinjuje rezultate ispitivanja terapije održavanja pemetreksedom JMEN ispitivanja (N=663) i kontinuirane terapije održavanja pemetreksedom PARAMOUNT ispitivanja (N=539).
English: • If you start feeling chest pain (common) or having a fast heart rate (uncommon).
Croatian: • ako počnete osjećati bolove u prsnom košu (često) ili ubrzane srčane otkucaje (manje često)
English: • Response rate (%) (95% CI)
Croatian: • stopa odgovora (%) (95% CI)
English: Alkaline phosphatase, AST, and ALT ≤ 5-times upper limit of normal is acceptable if liver has tumour involvement.
Croatian: Prihvatljive su vrijednosti alkalne fosfataze, AST-a i ALT-a od ≤ 5 puta iznad gornje granice normale ako je jetra zahvaćena tumorom.
English: If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with Pemetrexed Pfizer.
Croatian: Ako ste nedavno cijepljeni, obavijestite o tome svog liječnika jer to može izazvati štetne učinke uz primjenu lijeka Pemetreksed Pfizer.
English: 100% of previous dose
Croatian: 100% prethodne doze
English: 75% of previous dose (both pemetrexed and cisplatin)
Croatian: 75% prethodne doze (i pemetrekseda i cisplatina)
English: Concomitant use contraindicated Yellow fever vaccine: Risk of fatal generalised vaccinale disease (see section 4.3).
Croatian: Kontraindicirana je istodobna primjena Cjepiva protiv žute groznice: zbog rizika od smrtonosne generalizirane vakcinalne bolesti (vidjeti dio
English: Rarely, skin reactions may be severe and could lead to death.
Croatian: Kožne reakcije u rijetkim slučajevima mogu biti teške i potencijalno smrtonosne.
English: If not used immediately, in use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C.
Croatian: Ako se ne primijeni odmah, vrijeme i način čuvanja prije primjene odgovornost je korisnika i normalno ne smije biti duže od 24 sata pri temperaturi od 2°C do 8°C.
English: Patients with hepatic impairment
Croatian: Bolesnici s oštećenjem jetre
English: Grade 3 or 4 mucositis
Croatian: Mukozitis stupnja 3 ili 4
English: Malignant pleural mesothelioma
Croatian: Maligni pleuralni mezoteliom
English: Dose for cisplatin (mg/m2)
Croatian: Doza cisplatina (mg/m
English: Each pack contains one glass vial of 100 mg, 500 mg or 1,000 mg pemetrexed.
Croatian: Jedno pakiranje sadrži jednu staklenu bočicu od 100 mg, 500 mg ili 1000 mg pemetrekseda.
English: * Refer to National Cancer Institute CTC version 2 for each grade of toxicity except the term “creatinine clearance decreased”.
Croatian: * Za sve stupnjeve toksičnosti vidjeti Nacionalni institut za rak CTC verziju 2, osim za izraz „smanjen klirens kreatinina”.
English: Adjusted hazard ratio (HR) (95% CI)
Croatian: Prilagođeni omjer hazarda (HR) (95% CI)
English: In addition, infection with or without fever, diarrhoea, and/or mucositis may be seen.
Croatian: Uz to je moguća i pojava infekcije, sa ili bez vrućice, te proljev i/ili mukozitis.
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1,000 micrograms) that you must take once a day while you are taking Pemetrexed Pfizer.
Croatian: Vitaminska nadoknada: liječnik će Vam propisati folatnu kiselinu (vitamin) koja se uzima kroz usta ili multivitaminski pripravak koji sadrži folatnu kiselinu (350 do 1000 mikrograma), koji morate uzimati jedanput na dan za vrijeme liječenja lijekom Pemetreksed Pfizer.