FrancophonIA/ELRC3.0 huggingface dataset:
English: In the REACH study, infections were reported in 56.3% of randomised subjects treated with infliximab.
Croatian: U kliničkom ispitivanju REACH infekcije su prijavljene u 56,3% randomiziranih ispitanika liječenih infliksimabom.
English: Alternatively, administration of 3 mg/kg as often as every 4 weeks may be considered.
Croatian: Alternativno, može se razmotriti primjena doze od 3 mg/kg svaka 4 tjedna.
English: • The active substance is infliximab.
Croatian: • Djelatna tvar je infliksimab.
English: The combination of Remicade and abatacept is not recommended.
Croatian: Ne preporučuje se kombinirana primjena lijeka Remicade i abatacepta.
English: In a fertility and general reproductive function study, the number of pregnant mice was reduced following administration of the same analogous antibody.
Croatian: U istraživanju utjecaja na plodnost i opću reproduktivnu sposobnost, broj skotnih ženki miševa smanjio se nakon primjene istog analognog protutijela.
English: Patients with fistulising Crohn's disease with acute suppurative fistulas must not initiate Remicade therapy until a source for possible infection, specifically abscess, has been excluded (see section 4.3).
Croatian: Bolesnici s fistulirajućim oblikom Crohnove bolesti s akutnim, gnojnim fistulama ne smiju započeti liječenje lijekom Remicade dok se ne otkloni izvor moguće infekcije, osobito apsces (vidjeti dio 4.3).
English: In clinical studies with infliximab in which 5,780 patients were treated, representing 5,494 patient years, 5 cases of lymphomas and 26 non-lymphoma malignancies were detected as compared with no lymphomas and 1 non-lymphoma malignancy in 1,600 placebo-treated patients representing 941 patient years.
Croatian: U kliničkim ispitivanjima s infliksimabom u kojima je liječeno 5780 bolesnika, što predstavlja ukupno 5494 bolesnik-godina, otkriveno je 5 slučajeva limfoma i 26 slučajeva zloćudnih bolesti koje nisu bili limfomi, u odnosu na niti jedan slučaj limfoma i jedan slučaj zloćudne bolesti koja nije bila limfom u 1600 bolesnika koji su primali placebo, što predstavlja ukupno 941 bolesnik-godinu.
English: Placebo patients in the 2 Phase III studies in Crohn's disease, ACCENT I and ACCENT II, received an initial dose of 5 mg/kg infliximab at study start and were on placebo in the maintenance phase.
Croatian: Bolesnici u placebo skupini u dva klinička ispitivanja faze III u Crohnovoj bolesti, ACCENT I i ACCENT II, primili su inicijalnu dozu infliksimaba od 5 mg/kg na početku ispitivanja, dok su u fazi održavanja primali placebo.
English: Infections were reported in 31 (51.7%) of 60 treated patients in C0168T72 and 22 (36.7%) required oral or parenteral antimicrobial treatment.
Croatian: Infekcije su prijavljene u 31 od 60 liječenih bolesnika (51,7%) u ispitivanju C0168T72, od kojih je u njih 22 (36,7%) bila potrebna peroralna ili parenteralna antibiotska terapija.
English: control = All patients had active RA despite treatment with stable methotrexate doses for 6 months prior to enrolment and were to remain on stable doses throughout the study.
Croatian: kontrolna skupina = svi su bolesnici imali aktivni reumatoidni artritis usprkos liječenju ustaljenim dozama metotreksata tijekom 6 mjeseci prije uključenja u ispitivanje i trebali su nastaviti s uzimanjem istih doza tijekom čitavog ispitivanja.
English: In the infliximab group, the mean change in total modified vdH-S score remained below 0 at the week 54 timepoint.
Croatian: U skupini koja je primala infliksimab, prosječna promjena ukupnog rezultata po van der Heijdeu modificiranoj Sharpovoj bodovnoj skali ostala je ispod 0 u 54. tjednu.
English: At week 24, the placebo group crossed over to infliximab induction therapy (5 mg/kg) followed by infliximab maintenance therapy (5 mg/kg).
Croatian: U 24. tjednu skupina koja je primala placebo prebačena je na uvodnu terapiju infliksimaba (5 mg/kg), a zatim na terapiju održavanja infliksimabom (5 mg/kg).
English: Almost all patients had received treatment with AZA or 6-MP concomitantly with or immediately prior to a TNF-blocker.
Croatian: Gotovo svi ti bolesnici liječeni su azatioprinom (AZA) ili 6-MP istodobno ili neposredno prije primjene TNF-blokatora.
English: More signs of allergic side effects that may happen up to 12 days after your injection include pain in the muscles, fever, joint or jaw pain, sore throat or headache.
Croatian: Drugi znakovi alergijskih nuspojava koji se mogu javiti i do 12 dana nakon infuzije su bol u mišićima, vrućica, bol u zglobovima ili čeljusti, grlobolja ili glavobolja.
English: • It is very important that you tell your doctor if you have ever had TB or if you have been in close contact with someone who has had or has TB.
Croatian: • Vrlo je važno da obavijestite svog liječnika ako ste ikada bolovali od tuberkuloze (TBC-a) ili bili u bliskom kontaktu s osobom koja je bolovala ili boluje od tuberkuloze.
English: Dosing continued for all patients through week 46.
Croatian: Svi su bolesnici nastavili primati lijek do 46. tjedna.
English: The proportion of subjects in clinical response at week 10 was 88.4% (99/112).
Croatian: Udio ispitanika s kliničkim odgovorom u 10. tjednu iznosio je 88,4% (99/112).
English: This includes multiple sclerosis, Guillain-Barre syndrome, if you have fits or have been diagnosed with ‘optic neuritis'.
Croatian: To uključuje multiplu sklerozu, Guillain-Barreov sindrom, epileptičke napadaje ili dijagnozu "optičkog neuritisa".
English: Rare: Anaphylactic shock, vasculitis, sarcoid-like reaction.
Croatian: Rijetko: anafilaktički šok, vaskulitis, reakcija nalik na sarkoidozu
English: This will depend on your disease, weight and how well you respond to Remicade.
Croatian: Vašoj bolesti, tjelesnoj težini i odgovoru na liječenje.
English: Tumour necrosis factor alpha (TNF) mediates inflammation and modulates cellular immune responses.
Croatian: Faktor nekroze tumora alfa (TNFα) posreduje upalu i modulira stanične imunološke odgovore.
English: Use of TNF-blocking agents, including infliximab, has been associated with cases of new onset or exacerbation of clinical symptoms and/or radiographic evidence of central nervous system demyelinating disorders, including multiple sclerosis, and peripheral demyelinating disorders, including Guillain-Barré syndrome.
Croatian: Primjena lijekova koji inhibiraju TNF, uključujući infliksimab, dovodi se u vezu sa slučajevima nastajanja novih ili egzacerbacijom postojećih kliničkih simptoma i/ili radioloških nalaza demijelinizacijskih bolesti središnjeg živčanog sustava, uključujući multiplu sklerozu, te demijelinizacijskih poremećaja perifernog živčanog sustava, uključujući Guillain-Barréov sindrom.
English: If jaundice and/or ALT elevations ≥ 5 times the upper limit of normal develop(s), Remicade should be discontinued, and a thorough investigation of the abnormality should be undertaken.
Croatian: Ako se razvije žutica i/ili je koncentracija ALT ≥ 5 puta veća od gornje granice normale, liječenje lijekom Remicade treba prekinuti te provesti temeljite pretrage i utvrditi razlog poremećaja.
English: In most patients, infliximab could be detected in the serum for at least 8 weeks after the recommended single dose of 5 mg/kg for Crohn's disease and the rheumatoid arthritis maintenance dose of 3 mg/kg every 8 weeks.
Croatian: U većini se slučajeva infliksimab mogao pronaći u serumu još najmanje 8 tjedana nakon jednokratne primjene preporučene doze od 5 mg/kg u bolesnika s Crohnovom bolešću i doze održavanja od 3 mg/kg primijenjene svakih 8 tjedana u bolesnika s reumatoidnim artritisom.
English: Significant improvements in health-related quality of life were also demonstrated as measured by the physical and mental component summary scores of the SF-36 in IMPACT 2.
Croatian: Dokazano je i značajno poboljšanje kvalitete života povezane sa zdravljem, mjereno ukupnim zbrojem rezultata fizičkih i mentalnih parametara u upitniku SF-36 u ispitivanju IMPACT 2.
English: Overall, the adverse reactions reported in the paediatric ulcerative colitis trial (C0168T72) and adult ulcerative colitis (ACT 1 and ACT 2) studies were generally consistent.
Croatian: Ukupno uzevši, nuspojave prijavljene u ispitivanjima ulceroznog kolitisa u pedijatrijskih bolesnika (C0168T72) i odraslih (ACT 1 i ACT 2) općenito su bile konzistentne.
English: Data to support dose titration in rheumatoid arthritis come from ATTRACT, ASPIRE and the START study.
Croatian: Titraciju doze u bolesnika s reumatoidnim artritisom podupiru podaci koji dolaze iz ispitivanja ATTRACT, ASPIRE i START.
English: • A rare blood cancer affecting mostly teenage boys or young men (hepatosplenic T-cell lymphoma)
Croatian: • rijedak rak krvnih stanica koji se najčešće javlja u dječaka tinejdžerske dobi ili mlađih muškaraca (hepatosplenički limfom T-stanica)
English: • It is very important that you tell your doctor if you have ever had TB, or if you have been in close contact with someone who has had TB.
Croatian: • Vrlo je važno da obavijestite liječnika ako ste ikada bolovali od tuberkuloze (TBC-a) ili bili u bliskom kontaktu s osobom koja je bolovala od tuberkuloze.
English: Data about fistulas were derived from PCDAI scores.
Croatian: Podaci o fistulama izvedeni su iz pedijatrijskog CDAI rezultata.
English: Cases of malignancies, including lymphoma, have also been reported in the post-marketing setting (see section 4.4).
Croatian: Slučajevi zloćudnih bolesti, uključujući limfom, prijavljeni su i nakon stavljanja lijeka u promet (vidjeti dio 4.4.).
English: SPIRIT evaluated the efficacy of infliximab induction therapy in 249 patients with plaque psoriasis that had previously received PUVA or systemic therapy.
Croatian: U ispitivanju SPIRIT ocjenjivala se djelotvornost uvodne terapije infliksimabom u 249 bolesnika s plak psorijazom koji su prethodno bili liječeni PUVA ili sustavnom terapijom.
English: Cases of TB have been reported in patients treated with Remicade, even in patients who have already been treated with medicines for TB.
Croatian: U bolesnika liječenih lijekom Remicade prijavljeni su slučajevi tuberkuloze, čak i u bolesnika koji su već bili liječeni lijekovima protiv TBC-a.
English: • Immune disorders that could affect the lungs, skin and lymph nodes (such as sarcoidosis).
Croatian: • poremećaji imunološkog sustava koji mogu zahvatiti pluća, kožu i limfne čvorove (kao što je sarkoidoza)
English: With the current knowledge, a risk for the development of lymphomas or other malignancies in patients treated with a TNF-blocking agent cannot be excluded (see section 4.8).
Croatian: S obzirom na dosadašnje spoznaje, ne može se isključiti rizik od pojave limfoma ili drugih zloćudnih bolesti u bolesnika koji se liječe TNF-blokatorom (vidjeti dio 4.8).
English: The primary endpoint in both studies was the percent of patients who achieved ≥ 75% improvement in PASI from baseline at week 10.
Croatian: Primarna mjera ishoda u oba ispitivanja bio je postotak bolesnika u kojih se postiglo poboljšanje vrijednosti PASI za ≥ 75% u 10. tjednu u odnosu na početno stanje.
English: In psoriasis patients, treatment with infliximab resulted in decreases in epidermal inflammation and normalisation of keratinocyte differentiation in psoriatic plaques.
Croatian: U bolesnika s psorijazom, liječenje infliksimabom dovelo je do smanjenja upale u epidermalnom sloju i normalizacije diferencijacije keratocita u psorijatičnim plakovima.
English: • Signs of a nervous system problem (including eye problems) such as signs of a stroke (sudden numbness or weakness of your face, arm or leg, especially on one side of your body; sudden confusion, trouble speaking or understanding; trouble seeing in one or both eyes, trouble walking, dizziness, loss of balance or coordination or a severe headache), fits, tingling/numbness in any part of your body, or weakness in arms or legs, changes in eyesight such as double vision or other eye problems.
Croatian: • Znakove neuroloških problema (uključujući poremećaje oka) kao što su znakovi moždanog udara (iznenadna utrnulost ili slabost lica, ruke ili noge, osobito na jednoj strani tijela; iznenadna smetenost, otežan govor ili razumijevanje; tegobe s vidom koje zahvaćaju jedno ili oba oka, otežan hod, omaglica, gubitak ravnoteže ili koordinacije ili jaka glavobolja), napadaji, trnci/obamrlost bilo kojeg dijela tijela ili slabost u rukama ili nogama, promjene vida poput dvostruke slike ili drugi problemi s očima.
English: • treatment of fistulising, active Crohn's disease, in adult patients who have not responded despite a full and adequate course of therapy with conventional treatment (including antibiotics, drainage and immunosuppressive therapy).
Croatian: • liječenje fistulirajuće, aktivne Crohnove bolesti u odraslih bolesnika koji nisu odgovorili na punu i odgovarajuću konvencionalnu terapiju (uključujući antibiotike, drenažu i imunosupresijsku terapiju).
English: Efficacy was similar in the subgroup of patients that were exposed to previous systemic therapies compared to the overall study population.
Croatian: Djelotvornost u podskupini bolesnika koji su prethodno liječeni sustavnom terapijom bila je slična onoj u čitavom uzorku ispitanika.
English: In a 6-month repeated dose toxicity study in mice, using the same analogous antibody against mouse TNF, crystalline deposits were observed on the lens capsule of some of the treated male mice.
Croatian: U šestomjesečnom istraživanju toksičnosti ponovljenih doza na miševima pomoću istog analognog protutijela na mišji TNFα, u nekih su mužjaka miševa uočeni kristalični depoziti na kapsuli leće.
English: Elevations of aminotransferases were observed (ALT more common than AST) in a greater proportion of patients receiving Remicade than in controls, both when Remicade was given as monotherapy and when it was used in combination with other immunosuppressive agents.
Croatian: Povišene aminotransferaze (češće ALT nego AST) primijećene su u većem postotku u bolesnika koji su primali Remicade nego u kontrolnim skupinama, kako pri primjeni lijeka Remicade u monoterapiji, tako i pri primjeni u kombinaciji s drugim imunosupresivima.
English: Uncommon: Autoantibody positive.
Croatian: Manje često: pozitivan nalaz na autoprotutijela
English: In clinical studies using single and multiple infliximab doses ranging from 1 to 20 mg/kg, antibodies to infliximab were detected in 14% of patients with any immunosuppressant therapy, and in 24% of patients without immunosuppressant therapy.
Croatian: U kliničkim ispitivanjima primjene jednokratnih i višekratnih doza infliksimaba od 1 do 20 mg/kg, protutijela na infliksimab otkrivena su u 14% bolesnika koji su primali neku imunosupresivnu terapiju te u 24% bolesnika koji nisu primali imunosupresivnu terapiju.
English: • Tell your doctor if you have an infection even if it is a very minor one
Croatian: • Obavijestite liječnika ako imate neku infekciju, čak i ako je vrlo blaga.
English: Your doctor will record these tests on your patient reminder card.
Croatian: Liječnik će upisati da ste obavili navedene pretrage u Vašu karticu s podsjetnikom za bolesnika.
English: Nine of these patients developed malignancies, including 1 lymphoma.
Croatian: Devet bolesnika razvilo je zloćudnu bolest, uključujući limfom u jednom slučaju.
English: Concurrent use of stable doses of conventional therapies was permitted, and 92% of patients continued to receive these therapies.
Croatian: Bila je dopuštena istodobna primjena konvencionalne terapije u ustaljenoj dozi, koju je nastavilo primati 92% bolesnika.
English: The co-primary endpoints were the proportion of patients in clinical remission (CDAI < 150) at week 30 and time to loss of response through week 54.
Croatian: Dvije primarne mjere ishoda bile su udio bolesnika u kliničkoj remisiji (CDAI < 150) u 30. tjednu i vrijeme do gubitka odgovora do 54. tjedna.
English: Week 10
Croatian: 10. tjedan
English: • Convulsions, nerve problems
Croatian: • konvulzije (epileptički napadaji), tegobe sa živcima
English: All 3 groups received repeated infusions at week 2, 6 and every 8 weeks thereafter.
Croatian: Bolesnici u sve 3 skupine primili su ponovne infuzije u 2. i 6. tjednu te svakih 8 tjedana nakon toga.
English: • Some patients treated with infliximab have developed certain kinds of skin cancer.
Croatian: • U nekih bolesnika liječenih infliksimabom razvile su se određene vrste raka kože.
English: Some patients who developed high titres of antibodies to infliximab had evidence of reduced efficacy.
Croatian: U nekih bolesnika koji su razvili visoki titar protutijela na infliksimab bilo je dokaza smanjene djelotvornosti lijeka.
English: • Some women being treated for rheumatoid arthritis with Remicade have developed cervical cancer.
Croatian: • U nekih žena koje su se liječile lijekom Remicade zbog reumatskog artritisa, razvio se rak grlića maternice.
English: In psoriasis patients treated with infliximab as a maintenance regimen in the absence of concomitant immunomodulators, approximately 28% developed antibodies to infliximab (see section 4.4: “Infusion reactions and hypersensitivity”).
Croatian: Približno 28% bolesnika s psorijazom liječenih infliksimabom kao terapijom održavanja bez istodobnog liječenja imunomodulatorima razvilo je protutijela na infliksimab (vidjeti dio 4.4: "Reakcije na infuziju i preosjetljivost").
English: Continued therapy should be carefully reconsidered in patients who show no evidence of therapeutic benefit within the first 12 weeks of treatment or after dose adjustment.
Croatian: Treba pomno razmotriti nastavak liječenja u bolesnika u kojih nema dokaza o koristi terapije u prvih 12 tjedana liječenja ili nakon prilagođavanja doze.
English: Among patients classified as non-responders at week 2, 32% (26/81) in the placebo maintenance group and 42% (68/163) in the infliximab group achieved clinical response by week 6.
Croatian: Od bolesnika koji su klasificirani kao oni koji nisu odgovorili u 2. tjednu, njih 32% (26/81) u skupini koja je primala placebo i 42% (68/163) u skupini koja je primala infliksimab postiglo je klinički odgovor do 6. tjedna.
English: ≥ 50% improvement
Croatian: Poboljšanje ≥ 50%
English: ≥ 3 x ULN
Croatian: ≥ 3 x GGN
English: Rare: Lymphoma, non-Hodgkin's lymphoma, Hodgkin's disease, leukaemia, melanoma, cervical cancer.
Croatian: Rijetko: limfom, ne-Hodgkinov limfom, Hodgkinova bolest, leukemija,
English: EXPRESS evaluated the efficacy of infliximab induction and maintenance therapy in 378 patients with plaque psoriasis.
Croatian: U ispitivanju EXPRESS ocjenjivala se djelotvornost uvodne terapije i terapije održavanja infliksimabom u 378 bolesnika s plak psorijazom.
English: • Maintenance: Additional infusions of 5 mg/kg every 8 weeks or
Croatian: • terapija održavanja: dodatne infuzije u dozi od 5 mg/kg svakih 8 tjedana ili
English: In clinical studies, delayed hypersensitivity reactions have been uncommon and have occurred after Remicade-free intervals of less than 1 year (see sections 4.4 and 4.8).
Croatian: U kliničkim su ispitivanjima reakcije kasne preosjetljivosti bile manje česte i javljale su se nakon što se Remicade nije primjenjivao u razdoblju kraćem od godinu dana (vidjeti dijelove 4.4 i 4.8).
English: • Shortage of blood supply, swelling of a vein
Croatian: • nedostatna opskrba krvlju, oticanje vena
English: • You should avoid getting pregnant when you are being treated with Remicade and for 6 months after you stop being treated with it.
Croatian: • Potrebno je izbjegavati trudnoću tijekom liječenja lijekom Remicade i 6 mjeseci nakon završetka liječenja.
English: Names and addresses of the manufacturer(s) of the biological active substance(s)
Croatian: Nazivi i adrese proizvođača biološke(ih) djelatne(ih) tvari
English: Currently available data are described in sections 4.8 and 5.2 but no recommendation on a posology can be made.
Croatian: Do sada dostupni podaci opisani su u dijelovima 4.8 i 5.2, međutim nije moguće dati preporuku o doziranju.
English: Eighty nine percent (50/56) of patients who lost clinical response on infliximab 5 mg/kg maintenance therapy after week 14 responded to treatment with infliximab 10 mg/kg.
Croatian: Osamdeset i devet posto (50/56) bolesnika u kojih se klinički odgovor na terapiju održavanja infliksimabom u dozi od 5 mg/kg izgubio nakon 14. tjedna reagiralo je na liječenje infliksimabom u dozi od 10 mg/kg.
English: • Re-administration: Infusion of 5 mg/kg if signs and symptoms of the disease recur followed by infusions of 5 mg/kg every 8 weeks (see ‘Re-administration' below and section 4.4).
Croatian: • ponovna primjena: infuzija u dozi od 5 mg/kg ako se ponovno pojave znakovi i simptomi bolesti, nakon čega slijede infuzije u dozi od 5 mg/kg svakih 8 tjedana (vidjeti "Ponovna primjena" u daljnjem tekstu i dio 4.4).
English: The pooled data analysis from the ACT 1 and ACT 2 studies and their extensions, analysed from baseline through 54 weeks, demonstrated a reduction of ulcerative colitis-related hospitalisations and surgical procedures with infliximab treatment.
Croatian: Zbirni podaci iz ispitivanja ACT 1 i ACT 2 i njihovih nastavaka, analizirani od početka do kraja 54. tjedna, pokazali su da je pri liječenju infliksimabom smanjen broj hospitalizacija kao i kirurških zahvata vezanih uz ulcerozni kolitis.
English: Due to a number of treatment withdrawals, the magnitude of the effect difference between infliximab and the methotrexate alone group cannot be defined.
Croatian: Budući da je veći broj bolesnika prekinuo liječenje, ne može se odrediti značaj razlike u učinku infliksimaba i samog metotreksata.
English: In a Phase II study aimed at evaluating Remicade in CHF, higher incidence of mortality due to worsening of heart failure were seen in patients treated with Remicade, especially those treated with the higher dose of 10 mg/kg (i.e. twice the maximum approved dose).
Croatian: U kliničkom ispitivanju faze II s ciljem procjene učinka lijeka Remicade na kongestivno zatajenje srca uočena je veća incidencija mortaliteta uslijed pogoršanja srčane funkcije u bolesnika liječenih lijekom Remicade, osobito u onih koji su primali dozu veću od 10 mg/kg (tj. dvostruko veću od maksimalne odobrene doze).
English: Infusion reactions occurred in 35% of patients with juvenile rheumatoid arthritis receiving 3 mg/kg compared with 17.5% of patients receiving 6 mg/kg.
Croatian: Reakcije na infuziju javile su se u 35% bolesnika s juvenilnim reumatoidnim artritisom koji su primali dozu od 3 mg/kg i u 17,5% bolesnika koji su primali dozu od 6 mg/kg.
English: • That treatment with Remicade may increase the risks of serious infections/sepsis, opportunistic infections, tuberculosis, hepatitis B reactivation, and BCG breakthrough in infants with in utero exposure to infliximab, and when to seek attention from a HCP
Croatian: • napomenu da liječenje lijekom Remicade može povećati rizik od ozbiljnih infekcija/sepse,oportunističkih infekcija, tuberkuloze, reaktivacije hepatitisa B i probojne infekcije BCG-om u dojenčadi koja je bila izložena infliksimabu in utero, te kada je potrebno zatražiti medicinsku pomoć od zdravstvenog radnika
English: • If your doctor feels that you are at risk for TB, you may be treated with medicines for TB
Croatian: • Ako liječnik misli da kod Vas postoji rizik od razvoja TBC-a, prije nego primite Remicade možda ćete dobiti lijekove za liječenje TBC-a.
English: Indication Number of patients
Croatian: Broj bolesnika
English: In a subset of 90 adult patients with rheumatoid arthritis from the ASPIRE study a similar proportion of patients in each treatment group (methotrexate plus: placebo [n = 17], 3 mg/kg [n = 27] or 6 mg/kg Remicade [n = 46]) mounted an effective two-fold increase in titers to a polyvalent pneumococcal vaccine, indicating that Remicade did not interfere with T-cell independent humoral immune responses.
Croatian: U podskupini od 90 odraslih bolesnika s reumatoidnim artritisom iz ispitivanja ASPIRE, sličan je udio bolesnika u svim liječenim skupinama (metotreksat plus: placebo [n = 17], Remicade u dozi od 3 mg/kg [n = 27] ili Remicade u dozi od 6 mg/kg [n = 46]) ostvario učinkovito dvostruko povećanje titra kao odgovor na polivalentno pneumokokno cjepivo, što ukazuje na to da Remicade nije utjecao na humoralne imunološke odgovore neovisne o T-stanicama.