FrancophonIA/ELRC3.0 huggingface dataset:
English: The frequencies are based on studies and post-marketing experience in gout patients.
Slovenian: Pogostnost temelji na študijah in izkušnjah v obdobju trženja pri bolnikih s protinom.
English: Febuxostat treatment should not be started until an acute attack of gout has completely subsided.
Slovenian: Zdravljenje s febuksostatom se ne sme začeti, dokler se akutni zagon protina popolnoma ne izboljša.
English: • anaphylactic reactions, drug hypersensitivity (see also section 2 “Warnings and precautions”)
Slovenian: • anafilaktične reakcije, preobčutljivost na zdravilo (glejte tudi poglavje »Opozorila in previdnostni ukrepi”)
English: Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development or parturition (see section 5.3).
Slovenian: Študije na živalih ne kažejo na neposredne ali posredne škodljive vplive na nosečnost, razvoj zarodka/ploda ali porod (glejte poglavje 5.3).
English: If you develop a rash or these skin symptoms, seek immediate advice from a doctor and tell them that you are taking this medicine.
Slovenian: Če se pri vas razvije izpuščaj ali ti kožni simptomi, se nemudoma posvetujte z zdravnikom in mu povejte, da jemljete to zdravilo.
English: Data on a very limited number of exposed pregnancies have not indicated any adverse effects of febuxostat on pregnancy or on the health of the foetus/new born child.
Slovenian: Podatki, zbrani pri zelo majhnem številu nosečnic, niso pokazali neželenih učinkov febuksostata na nosečnost ali zdravje zarodka/novorojenca.
English: In vitro studies with human liver microsomes showed that those oxidative metabolites were formed primarily by CYP1A1, CYP1A2, CYP2C8 or CYP2C9 and febuxostat glucuronide was formed mainly by UGT 1A1, 1A8, and 1A9.
Slovenian: In vitro študije s človeškimi jetrnimi mikrosomi so pokazale, da ti oksidirani presnovki nastajajo pretežno s CYP1A1, CYP1A2, CYP2C8 ali CYP2C9, febuksostat glukuronid pa nastane pretežno z UGT 1A1, 1A8 in 1A9.
English: Liver function test is recommended prior to the initiation of therapy with febuxostat and periodically thereafter based on clinical judgment (see section 5.1).
Slovenian: Preverjanje delovanja jeter se priporoča pred začetkom zdravljenja s febuksostatom in nato periodično v skladu s klinično presojo (glejte poglavje 5.1).
English: Prevention and treatment of hyperuricaemia in patients at risk of TLS
Slovenian: Preventiva in zdravljenje hiperuikemije pri bolnikih s tveganjem za TLS
English: The effect of febuxostat on human fertility is unknown.
Slovenian: Učinek febuksostata na plodnost pri človeku ni znan.
English: Carcinogenesis, mutagenesis, impairment of fertility
Slovenian: Karcinogeneza, mutageneza, škodljivo delovanje na plodnost
English: • increased sweating
Slovenian: • čezmerno znojenje,
English: INNER CARTON OF MULTIPACK (WITHOUT BLUE BOX)
Slovenian: NOTRANJA ŠKATLA VEČKRATNEGA PAKIRANJA (BREZ MODREGA OKENCA)
English: The endpoints (primary and secondary) were analysed according to the intention-to-treat (ITT) analysis including all subjects who were randomized and received at least one dose of doubleblind study medication.
Slovenian: Opazovane dogodke (primarne in sekundarne) so preučili v skladu z analizo vključenih bolnikov (ITT - Intention-To-Treat), ki je vključevala vse bolnike, ki so bili randomizirani in so prejeli vsaj en odmerek dvojno slepega zdravila v preskušanju.
English: Patients should be advised of the signs and symptoms and monitored closely for symptoms of allergic/hypersensitivity reactions (see section 4.8).
Slovenian: Bolnike je treba poučiti o znakih in simptomih ter pozorno spremljati simptome alergijskih/preobčutljivostnih reakcij (glejte poglavje 4.8).
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 (see also section 4.8).
Slovenian: Preobčutljivost za zdravilno učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1 (glejte tudi poglavje 4.8).
English: It may also include ulcers in the mouth, throat, nose, genitals and conjunctivitis (red and swollen eyes).
Slovenian: Spremljajo ga lahko razjede v ustih, grlu, nosu, genitalijah in konjuktivitis (rdeče in zatečene oči).
English: • sudden cardiac death
Slovenian: • nenadna srčna smrt.
English: Rare Tinnitus
Slovenian: Redki tinitus
English: The efficacy and safety of febuxostat has not been established in patients with acute severe TLS, e.g. in patients who failed on other urate lowering therapies.
Slovenian: Učinkovitost in varnost febuksostata nista bili dokazani pri bolnikih z akutno hudo TLS, npr. pri bolnikih, pri katerih zdravljenje z drugimi zdravili za zniževanje uratov ni bilo uspešno.
English: There was no significant increase in any other tumour type in either male or female mice or rats.
Slovenian: Pri drugih vrstah tumorjev niso opazili pomembnega povečanja pri podganjih ali mišjih samcih in samicah.
English: Treatment of chronic hyperuricaemia
Slovenian: Zdravljenje kronične hiperurikemije
English: Furthermore, the mean serum uric acid level was significantly lower with febuxostat since the first 24 hours of treatment and at any following time point.
Slovenian: Tudi srednja serumska vrednost sečne kisline je bila značilno manjša pri uporabi febuksostata od prvih 24 ur zdravljenja naprej in v vseh nadaljnih časovnih točkah.
English: BL=baseline SEM=standard error of the mean
Slovenian: BL = izhodišče, SEM = standardna napaka srednje vrednosti
English: For some people, gout attacks may flare up when starting certain medicines that control uric acid levels.
Slovenian: Pri nekaterih ljudeh se izbruh protina lahko pojavi, ko začnejo jemati nekatera zdravila, ki nadzirajo ravni sečne kisline.
English: Continuous treatment with febuxostat decreases frequency and intensity of gout flares.
Slovenian: Dolgotrajno zdravljenje s febuksostatom zmanjša pogostnost in intenzivnost izbruhov protina.
English: • loss of sex drive
Slovenian: • izguba spolne sle,
English: [For calendar blisters only]: MON
Slovenian: [Samo za koledarske pretisne omote]: PON
English: • increased level of creatine phosphokinase in blood (an indicator of muscle damage)
Slovenian: • povečane vrednosti kreatin fosfokinaze v krvi (indikator poškodbe mišic),
English: The mean serum uric acid levels over time for each treatment group from the two pivotal Phase 3 studies are shown in Figure 1.
Slovenian: Srednje vrednosti sečne kisline v serumu glede na čas za vsako skupino dveh ključnih študij 3. faze so prikazane na sliki 1.
English: In clinical studies the use of naproxen or other NSAIDs/Cox-2 inhibitors was not related to any clinically significant increase in adverse events.
Slovenian: V kliničnih študijah uporaba naproksena ali drugih NSAID/zaviralcev COX-2 ni bila povezana z nobenim klinično pomembnim povečanjem števila neželenih učinkov.
English: *** See section 5.1 for incidences of gout flares in the individual Phase 3 randomized controlled studies.
Slovenian: *** Glejte poglavje 5.1 za incidenco izbruhov protina v posameznih randomiziranih študijah 3. faze
English: If you are having a gout attack at the moment (a sudden onset of severe pain, tenderness, redness, warmth and swelling in a joint), wait for the gout attack to subside first before starting treatment with Febuxostat Mylan.
Slovenian: Če imate trenutno izbruh protina (nenadni občutek hude bolečine, napetosti, pordelosti, toplote in oteklosti sklepa), počakajte, da izbruh protina mine, preden začnete zdravljenje z zdravilom Febuksostat Mylan.
English: • Mercaptopurine (used to treat cancer)
Slovenian: • merkaptopurin (uporablja se za zdravljenje raka),
English: • If you have or have had heart failure, heart problems or stroke
Slovenian: • če imate ali ste imeli srčno popuščanje, težave s srcem ali možgansko kap,
English: These crystals can cause sudden, severe pain, redness, warmth and swelling in a joint (known as a gout attack).
Slovenian: Ti kristali lahko povzročijo nenadne hude bolečine, pordelost, toploto in oteklost v sklepu (znano kot izbruh protina).
English: Effects in non-clinical studies were generally observed at exposures in excess of the maximum human exposure.
Slovenian: V predkliničnih študijah so se učinki v glavnem pokazali le pri izpostavljenosti, ki je bila večja od največje izpostavljenosti človeka.
English: Keeping uric acid levels sufficiently low for a long enough period can also shrink tophi.
Slovenian: Ohranjanje nizke ravni sečne kisline dovolj dolgo lahko povzroči tudi zmanjšanje tofov.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, odsotnostjo encima laktaza ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: Common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100) and rare (≥1/10,000 to <1/1,000) adverse reactions occurring in patients treated with febuxostat are listed below.
Slovenian: Pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100) in redki ( 1/10.000 do < 1/1.000) neželeni učinki, ki so se pojavili pri bolnikih, ki so bili zdravljeni s febuksostatom, so našteti spodaj.
English: At least 65% of the patients had mild-moderate renal impairment (with creatinine clearance of 30-89 mL/min).
Slovenian: Najmanj 65 % bolnikov v tej študiji je imelo blago do zmerno okvaro ledvične funkcije (z očistkom kreatinina 30-89 ml/min).
English: It is especially important to tell your doctor or pharmacist if you are taking medicines containing any of the following substances as they may interact with Febuxostat Mylan and your doctor may wish to consider necessary measures:
Slovenian: Zlasti pomembno je, da zdravnika ali farmacevta obvestite, če jemljete zdravila, ki vsebujejo katero od naslednjih učinkovin, da bo vaš zdravnik ocenil, ali so potrebni ustrezni ukrepi, saj lahko pride do medsebojnega delovanja z zdravilom Febuksostat Mylan:
English: Some, but not all of these patients reported renal impairment and/or previous hypersensitivity to allopurinol.
Slovenian: Pri nekaterih od teh bolnikov, vendar ne pri vseh, so poročali o ledvični okvari in/ali preobčutljivosti na alopurinol.
English: There were no clinically significant differences in the percent decrease in serum uric acid concentration in healthy subjects irrespective of their renal function (58% in the normal renal function group and 55% in the severe renal dysfunction group).
Slovenian: Klinično pomembnih razlik v odstotku znižanja koncentracije sečne kisline v serumu pri zdravih prostovoljcih niso opazili ne glede na njihovo ledvično delovanje (58 % v skupini z normalnim delovanjem ledvic in 55 % v skupini s hudo motnjo delovanja ledvic).
English: Gout flares were commonly observed soon after the start of treatment and during the first months.
Slovenian: Izbruh putike se je pogosto pojavil takoj po začetku zdravljenja in v prvih mesecih.
English: • If you have or have had renal disease and/or serious allergic reaction to allopurinol (a medication used for the treatment of Gout)
Slovenian: • če imate ali ste imeli bolezen ledvic in/ali resne alergijske reakcije na alopurinol (zdravilo za zdravljenje protina),
English: Where the combination cannot be avoided, a reduction of the dose of mercaptopurine/azathioprine is recommended.
Slovenian: Če se kombinaciji ni mogoče izogniti, je priporočljivo zmanjšati odmerek merkaptopurina/azatioprina.
English: • changes or decrease in urine amount due to inflammation in the kidneys (tubulointerstitial nephritis)
Slovenian: • spremembe ali zmanjšanje količine urina zaradi vnetja ledvic (tubulointersticijski nefritis),
English: Multipack: 84 (2 packs of 42) film-coated tablets
Slovenian: Večkratno pakiranje: 84 (2 pakiranji po 42) filmsko obloženih tablet
English: Overall, the FLORENCE trial did not highlight any particular safety concern in addition to the previous experience with febuxostat in gout, with the exception of the following three adverse reactions (listed above in table 1).
Slovenian: Na splošno v FLORENCE študiji, glede na prejšnje izkušnje z zdravljenjem protina s febuksostatom, niso izpostavili nobenih posebnih varnostnih težav, z izjemo treh naslednjih neželenih učinkov (navedenih v preglednici 1 zgoraj):
English: Febuxostat 80 mg can be used in patients concomitantly treated with theophylline without risk of increasing theophylline plasma levels.
Slovenian: 80 mg febuksostata se pri bolnikih, ki se sočasno zdravijo s teofilinom, lahko uporablja brez tveganja za povečanje plazemskih vrednosti teofilina.
English: What Febuxostat Mylan is and what it is used for What you need to know before you take Febuxostat Mylan How to take Febuxostat Mylan Possible side effects
Slovenian: Kaj je zdravilo Febuksostat Mylan in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Febuksostat Mylan Kako jemati zdravilo Febuksostat Mylan Možni neželeni učinki
English: Concomitant ingestion of an antacid containing magnesium hydroxide and aluminium hydroxide has been shown to delay absorption of febuxostat (approximately 1 hour) and to cause a 32% decrease in Cmax, but no significant change in AUC was observed.
Slovenian: Pokazalo se je, da sočasno zaužitje antacida, ki vsebuje magnezijev hidroksid in aluminijev hidroksid, upočasni absorpcijo febuksostata (za približno 1 uro) in povzroči 32 % znižanje Cmax, toda značilne spremembe AUC niso opazili.
English: Tumour Lysis Syndrome: in the pivotal Phase III trial (FLORENCE) only subjects with severe hepatic insufficiency were excluded from trial participation.
Slovenian: Sindrom tumorske lize: v pilotski študiji 3. faze (FLORENCE) so bili samo bolniki s hudo jetrno insuficienco izključeni iz študije.
English: These tophi may cause joint and bone damage.
Slovenian: Tofi lahko poškodujejo sklepe in kosti.
English: Contact your doctor immediately if you experience muscle pain, tenderness or weakness
Slovenian: Nemudoma se posvetujte s svojim zdravnikom, če imate bolečine v mišicah, občutljive ali šibke mišice.
English: Colchicine/indometacin/hydrochlorothiazide/warfarin
Slovenian: Kolhicin/indometacin/hidroklorotiazid/varfarin
English: As there has been no experience in organ transplant recipients, the use of febuxostat in such patients is not recommended (see section 5.1).
Slovenian: Ker z uporabo pri bolnikih po presaditvi organa ni izkušenj, uporaba febuksostata pri teh bolnikih ni priporočljiva (glejte poglavje 5.1).
English: In animals, reproduction studies up to 48 mg/kg/day showed no dose-dependent adverse effects on fertility (see section 5.3).
Slovenian: Študije o razmnoževanju na živalih v odmerkih do 48 mg/kg/dan so pokazale, da ni z odmerkom odvisnih neželenih učinkov na plodnost (glejte poglavje 5.3).
English: Following multiple oral doses of febuxostat, the Cmax and AUC were 24% and 12% higher in females than in males, respectively.
Slovenian: Po večkratnih peroralnih odmerkih febuksostata sta bili Cmax za 24 % in AUC za 12 % večji pri ženskah kot pri moških.
English: The gout flare should be managed concurrently as appropriate for the individual patient.
Slovenian: Izbruh protina je treba obravnavati sočasno in posameznemu bolniku primerno.
English: Treatment with febuxostat in patients with pre-existing major cardiovascular diseases (e.g. myocardial infarction, stroke or unstable angina) should be avoided, unless no other therapy options are appropriate.
Slovenian: Zdravljenju s febuksostatom se je treba izogibati pri bolnikih z že obstoječimi hudimi srčno-žilnimi boleznimi (npr. miokardni infarkt, možganska kap ali nestabilna angina pektoris), razen če druge možnosti zdravljenja niso primerne.
English: Thus, febuxostat may be taken without regard to food.
Slovenian: Zato se lahko febuksostat jemlje ne glede na hrano.
English: • weight decrease, increased appetite, uncontrolled loss of appetite (anorexia)
Slovenian: • zmanjšanje telesne mase, povečanje apetita, nenadzorovana izguba apetita (anoreksija),
English: • If you have thyroid problems.
Slovenian: • če imate težave s ščitnico.
English: Xanthine deposition
Slovenian: Odlaganje ksantina
English: In healthy subjects concomitant use of febuxostat and naproxen 250 mg twice daily was associated with an increase in febuxostat exposure (Cmax 28%, AUC 41% and t1/2 26%).
Slovenian: Pri zdravih prostovoljcih je bila sočasna uporaba febuksostata in naproksena v odmerku 250 mg dvakrat na dan povezana z večjo izpostavljenostjo febuksostatu (Cmax 28 %, AUC 41 % in t1/2 26 %).
English: 240 mg febuxostat was used to evaluate the safety of febuxostat at twice the recommended highest dose.
Slovenian: Za ocenitev varnosti febuksostata ob dvakratnem najvišjem priporočenem odmerku so uporabili 240 mg febuksostata.
English: Keeping uric acid levels low by taking Febuxostat Mylan once every day stops crystals building up, and over time it reduces symptoms.
Slovenian: Jemanje zdravila Febuksostat Mylan enkrat na dan ohranja nizko raven sečne kisline in prepreči nastanek kristalov, dolgoročno pa zmanjša simptome.
English: Therefore, febuxostat may be taken without regard to antacid use.
Slovenian: Zato se lahko febuksostat jemlje ne glede na uporabo antacida.
English: Incidence of overall treatmentemergent signs and symptoms and adverse drug reactions was 67.6% vs 64.7% and 6.4% vs 6.4% with febuxostat and allopurinol respectively.
Slovenian: Incidenca z zdravljenjem povezanih znakov in simptomov ter neželenih učinkov je bila 67,6 % proti 64,7 % in 6,4 % za febuksostatu v primerjavi proti 6,4 % pri alopurinolu.
English: In each phase 3 pivotal study, febuxostat demonstrated superior ability to lower and maintain serum uric acid levels compared to allopurinol.
Slovenian: V vsaki ključni študiji 3. faze je febuksostat dokazal boljšo sposobnost zmanjšanja in vzdrževanja ravni sečne kisline v serumu v primerjavi z alopurinolom.
English: If a gout flare occurs during febuxostat treatment, it should not be discontinued.
Slovenian: Če se med zdravljenjem s febuksostatom pojavi izbruh protina, se zdravljenja ne sme prekiniti.
English: Elderly No dose adjustment is required in the elderly (see section 5.2).
Slovenian: Starejši Pri starostnikih odmerka ni treba prilagajati (glejte poglavje 5.2).
English: Should you experience allergic reactions to Febuxostat Mylan, stop taking this medicine (see also section 4).
Slovenian: Če se med zdravljenjem z zdravilom Febuksostat Mylan pojavijo alergijske reakcije, prenehajte jemati zdravilo (glejte tudi poglavje 4).
English: Therefore, possible interactions with any concomitantly administered cytotoxic drug cannot be ruled out.
Slovenian: Zato ni mogoče izključiti možnega medsebojnega delovanja s sočasno uporabljenim citotoksičnim zdravilom.
English: OUTER CARTON OF MULTIPACK (WITH BLUE BOX)
Slovenian: ZUNANJA ŠKATLA VEČKRATNEGA PAKIRANJA (Z MODRIM OKENCEM)
English: Figure 1 Mean Serum Uric Acid Levels in Combined Pivotal Phase 3 Studies
Slovenian: Slika 1: Srednje vrednosti sečne kisline v serumu v kombiniranih ključnih študijah 3. faze
English: • blood in the urine, abnormal frequent urination, abnormal urine tests (increased level of proteins in the urine), a reduction in the ability of the kidneys to function properly
Slovenian: • kri v urinu, nenormalno pogosto uriniranje, nenormalni rezultati testov urina (povišana raven beljakovin v urinu), oslabljeno delovanje ledvic,
English: [Bottles]
Slovenian: [Plastenke]
English: Animal studies have shown excretion of this active substance in breast milk and an impaired development of suckling pups.
Slovenian: Študije na živalih so pokazale izločanje učinkovine v mleko in slabši razvoj dojenih mladičev.
English: Primary endpoints were serum uric acid area under the curve (AUC sUA1-8) and change in serum creatinine (sC) level both from baseline to Day 8.
Slovenian: Primarni cilji so bili površina serumske sečne kisline pod krivuljo (AUC sUA1-8) in sprememba vrednosti serumskega kreatinina (sC) na samem začetku in do dneva 8.
English: The safety and the efficacy of febuxostat in children aged below the age of 18 years have not been established.
Slovenian: Varnost in učinkovitost febuksostata pri otrocih, starih do 18 let še nista bili dokazani.
English: No dose adjustment is needed based on gender.
Slovenian: Prilagajanje odmerka glede na spol ni potrebno.
English: It may cause muscle problems and particularly, if at the same time, you feel unwell or have a high temperature it may be caused by an abnormal muscle breakdown.
Slovenian: To lahko povzroči težave z mišicami in še posebej, če jih spremljata slabo počutje in vročina, je to lahko posledica neobičajnega razkroja mišičnega tkiva.
English: Both steps in the above transformations are catalyzed by xanthine oxidase (XO).
Slovenian: Obe stopnji v zgornji transformaciji katalizira ksantinska oksidaza.
English: Medicinal product allergy / hypersensitivity
Slovenian: Alergija na zdravilo/preobčutljivost
English: Identified risk factors among these patients were a medical history of atherosclerotic disease and/or myocardial infarction, or of congestive heart failure.
Slovenian: Pri teh bolnikih so bili ugotovljeni naslednji dejavniki tveganja: anamneza aterosklerotične bolezni in/ali miokardnega infarkta ali kongestivnega srčnega popuščanja.
English: Rosiglitazone/CYP2C8 substrates
Slovenian: Rosiglitazon/substrat CYP2C8
English: Mean (±SEM) Serum Uric Acid Level (mg/dL)
Slovenian: Srednje (±SEM) vrednosti sečne kisline v serumu (mg/dl)
English: Manufacturer Mylan Hungary Kft Mylan utca 1
Slovenian: Izdelovalec Mylan Hungary Kft Mylan utca 1
English: The patients should be closely monitored and the dose of mercaptopurine/azathioprine should be subsequently adjusted based on the evaluation of the therapeutic response and the onset of eventual toxic effects.
Slovenian: Bolnike je potrebno skrbno nadzirati, odmerek merkaptopurina/azatioprina pa mora biti posledično prilagojen glede na oceno terapevtskega odgovora in pojava morebitnih toksičnih učinkov.
English: Antacids
Slovenian: Antacidi
English: Overall, 346 patients with haematological malignancies undergoing chemotherapy and at intermediate/high risk of Tumor Lysis Syndrome were included.
Slovenian: V celoti je bilo vključenih 346 bolnikov s hematološkim malignim obolenjem, pri katerih poteka zdravljenje s kemoterapijo in s srednje visokim/visokim tveganjem za nastanek sindroma tumorske lize.
English: Thereafter, the frequency of gout flare decreases in a time-dependent manner.
Slovenian: Zato pogostnost izbruhov putike pada v odvisnosti od časa.
English: Authorisation Holder.
Slovenian: - Navodilo shranite.
English: In the randomized, double-blind, Phase 3 pivotal FLORENCE (FLO-01) study comparing febuxostat with allopurinol (346 patients undergoing chemotherapy for haematologic malignancies and at intermediate-to-high risk of TLS), only 22 (6.4%) patients overall experienced adverse reactions, namely 11 (6.4%) patients in each treatment group.
Slovenian: V randomizirani, dvojno slepi, pilotski študiji 3. faze FLORENCE (FLO-01), kjer so primerjali febuksostat z alopurinolom (346 bolnikov zdravljenih s kemoterapijo zaradi hematološkega malignega obolenja in s srednje visokim do visokim tveganjem za TLS), je v celoti le 22 (6,4 %) bolnikov imelo neželene učinke, in sicer 11 (6,4 %) bolnikov v vsaki zdravljeni skupini.
English: Conversely, cessation of treatment of an inducer might lead to increased plasma levels of febuxostat.
Slovenian: Nasprotno pa lahko prenehanje zdravljenja z induktorjem povzroči povišane ravni febuksostata v plazmi.
English: About 69% of patients required no treatment change to achieve a final stable treatment.
Slovenian: Približno 69 % zdravljenih bolnikov je doseglo končno stabilno stanje brez potrebne spremembe režima zdravljenja.
English: • decreased appetite, change in blood sugar levels (diabetes) of which a symptom may be excessive thirst, increased blood fat levels, weight increase
Slovenian: • zmanjšan apetit, spremembe ravni sladkorja v krvi (sladkorna bolezen), katerih simptom je huda žeja, povišane ravni maščob v krvi, povečanje telesne mase,