FrancophonIA/ELRC3.0 huggingface dataset:
English: Haematologic malignancies do not express the KGF receptor.
Croatian: Hematološke maligne stanice ne izražavaju receptor za čimbenike rasta keratinocita.
English: In studies in rats, no adverse effects on reproductivity/fertility parameters were observed at doses of up to 100 micrograms/kg/day.
Croatian: U istraživanjima na štakorima nisu utvrđeni štetni učinci na reproduktivni sustav/plodnost pri dozama do 100 mikrograma/kg/dan.
English: These NOAEL doses were associated with systemic exposures (based on AUC) up to 9.7 and 2.1 times, respectively, anticipated clinical exposure.
Croatian: Te doze pri kojima nisu uočeni štetni učinci bile su povezane sa sustavnim izlaganjem (na temelju AUC-a) do 9,7 puta većim za štakore i 2,1 puta većim za kuniće od predviđenog kliničkog izlaganja.
English: 6 vials containing powder for solution for injection
Croatian: 6 bočica s praškom za otopinu za injekciju
English: Palifermin
Croatian: Nuspojave
English: The conditioning regimen consisted of total body irradiation (TBI), etoposide and cyclophosphamide.
Croatian: Režim kondicioniranja sastojao se od ozračivanja cijelog tijela te primjene etopozida i ciklofosfamida.
English: These patient-reported outcomes were highly correlated to the clinician grading of
Croatian: Ovi ishodi koje su prijavili ispitanici u velikoj mjeri odgovaraju kliničkom stupnjevanju oralnog mukozitisa prema ljestvici SZO-a.
English: Palifermin is a growth factor that primarily stimulates epithelial cells through the KGF receptor.
Croatian: Palifermin je čimbenik rasta koji prvenstveno stimulira epitelne stanice putem receptora za čimbenike rasta keratinocita.
English: Each vial contains 6.25 mg of palifermin.
Croatian: Svaka bočica sadrži 6,25 mg palifermina.
English: What Kepivance looks like and contents of the pack Kepivance is a white powder supplied in vials.
Croatian: Kepivance je bijeli prašak koji se isporučuje u bočicama.
English: The recommended dosage of Kepivance is 60 micrograms/kg/day, administered as an intravenous bolus injection for three consecutive days before and three consecutive days after myeloablative radiochemotherapy for a total of six doses.
Croatian: Preporučena doza Kepivancea iznosi 60 mikrograma/kg/dan, primijenjena u obliku intravenske bolus injekcije kroz 3 uzastopna dana prije i 3 uzastopna dana nakon mijeloablativne radiokemoterapije,
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1, or to
Croatian: Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 6.1 ili na proteine dobivene iz Escherichie coli.
English: • hand-and-foot skin-reaction (palms of the hands or soles of the feet tingle, become numb,
Croatian: • kožne promjene na rukama i stopalima (trnci u dlanovima ili tabanima, utrnulost, bolnost,
English: Kepivance is a growth factor that stimulates the proliferation of KGF receptor expressing epithelial cells.
Croatian: Kepivance je čimbenik rasta koji potiče proliferaciju epitelnih stanica koje izražavaju receptore za čimbenike rasta keratinocita.
English: Oedema, oedema peripheral, pain and pyrexia
Croatian: Edem, periferni edem, bol i vrućica primjene
English: Efficacy and safety of palifermin were established in a randomised, double-blind, placebo-controlled study in which patients received high-dose cytotoxic therapy consisting of fractionated total-body irradiation (12 Gy total dose; Day -8 to -5), high-dose etoposide (60 mg/kg; Day -4), and high-dose cyclophosphamide (100 mg/kg; Day -2) followed by PBPC support for the treatment of haematological malignancies ((Non-Hodgkin's Lymphoma (NHL), Hodgkin's disease, Acute Myeloid Leukaemia (AML), Acute Lymphocytic Leukaemia (ALL), Chronic Myeloid Leukaemia (CML), Chronic Lymphocytic Leukaemia (CLL), or multiple myeloma).
Croatian: visoke doze etopozida (60 mg/kg; dan -4) i visoke doze ciklofosfamida (100 mg/kg; dan -2), nakon čega je primijenjena infuzija progenitornih stanica iz periferne krvi za liječenje hematoloških malignih bolesti (ne-Hodgkinovog limfoma (NHL), Hodgkinove bolesti, akutne mijeloične leukemije
English: A total of 27 paediatric patients with leukaemia were randomized to 40, 60 or 80 micrograms/kg/day of palifermin for 3 days pre- and post- hematopoietic stem cell transplantation (HSCT).
Croatian: Ukupno 27 pedijatrijskih bolesnika s leukemijom nasumično je raspoređeno u skupine koje su primale palifermin u dozi od 40, 60 ili 80 mikrograma/kg/dan 3 dana prije i nakon transplantacije krvotvornih matičnih stanica.
English: • an increase in the thickness in the mouth or tongue;
Croatian: • zadebljanje usne šupljine ili jezika;
English: In this study (n = 281), patients with multiple myeloma received conditioning with melphalan (200 mg/m2) prior to autologous haematopoietic stem cell transplantation.
Croatian: U sklopu ispitivanja (n = 281) bolesnici s multiplim mijelomom kondicionirani su melfalanom
English: Median (25th, 75th percentile) Cumulative Dose (morphine mg equivalents) Patient Incidence of Total Parenteral Nutrition (TPN)
Croatian: Opioidna analgezija za oralni mukozitis: Medijan (25., 75. percentila) dana 11 (8, 14) Medijan (25., 75. percentila) Kumulativna doza (ekvivalent morfija u mg) Incidencija bolesnika na totalnoj parenteralnoj prehrani Incidencija febrilne neutropenije u bolesnika
English: It differs from endogenous human KGF in that the first 23 N-terminal amino acids have been deleted to improve
Croatian: Od endogenog humanog čimbenika rasta keratinocita razlikuje se po tome što su prve 23
English: The last three doses should be administered post myeloablative radiochemotherapy; the first of these doses should be administered after, but on the same day of haematopoietic stem cell infusion and at least seven days after the most recent Kepivance administration (see section 4.4).
Croatian: doze treba primijeniti nakon liječenja, ali isti dan kao i infuziju krvotvornih matičnih stanica i najmanje sedam dana nakon zadnje primjenjene doze Kepivancea (vidjeti dio 4.4).
English: Package leaflet: Information for the user Kepivance 6.25 mg powder for solution for injection palifermin
Croatian: Uputa o lijeku: Informacija za korisnika Kepivance 6,25 mg prašak za otopinu za injekciju palifermin
English: Oral mucosal hypertrophy / Hypertrophy of tongue papillae,Oral mucosal discolouration / Tongue discolouration, Tongue disorder (e.g. redness, bumps), Tongue oedema
Croatian: Hipertrofija oralne sluznice /hipertrofija jezičnih papila, promjena boje oralne sluznice/promjena boje jezika,
English: In fertility/general reproductive toxicity studies in rats, palifermin treatment was associated with systemic toxicity (clinical signs and/or changes in body weight) and adverse effects on male and female reproductive/fertility parameters at doses greater than or equal to 300 micrograms/kg/day.
Croatian: U ispitivanjima toksičnosti za plodnost i opće reproduktivne toksičnosti na štakorima pri dozama višim ili jednakim 300 mikrograma/kg/dan liječenje paliferminom bilo je povezano sa sistemskom toksičnošću (klinički pokazatelji i/ili promjene u tjelesnoj težini) i štetnim učincima na muške i ženske parametre reprodukcije/plodnosti.
English: Palifermin is a human keratinocyte growth factor (KGF), produced by recombinant DNA technology
Croatian: Keratinocyte growth factor - KGF) koji se proizvodi tehnologijom rekombinantne DNK u stanicama Escherichia coli.
English: Patient incidence of WHO Grade 4 oral Median (25th, 75th percentile) days of
Croatian: Incidencija oralnog mukozitisa stupnja 4 prema ljestvici SZO u bolesnika Medijan (25., 75. percentila) dana oralnog mukozitisa stupnja 2/3/4 prema ljestvici SZO
English: In embryo/foetal development toxicity studies in rats and rabbits, palifermin treatment was associated with developmental toxicity (increased post-implantation loss, reduced litter size, and/or reduced foetal weight) at doses of 500 and 150 micrograms/kg/day, respectively.
Croatian: U ispitivanjima toksičnosti za razvoj embrija/fetusa provedenim na štakorima i kunićima pri dozama od 500 mikrograma/kg/dan za štakore i 150 mikrograma/kg/dan za kuniće liječenje paliferminom bilo je povezano s razvojnom toksičnošću (povećani postimplantacijski mortalitet, smanjena veličina legla i/ili smanjena težina fetusa).
English: A 3-fold or greater increase in Ki67 staining was observed in buccal biopsies from 3 of 6 healthy subjects given palifermin at 40 micrograms/kg/day intravenously for 3 days, when measured 24 hours after the third dose.
Croatian: U 3 od 6 zdravih ispitanika koji su 3 dana intravenski primali 40 mikrograma/kg/dan palifermina biopsijom bukalne sluznice 24 sata nakon 3. doze primijećeno je trostruko ili veće povećanje bojenja na Ki67.
English: Approximately dose-linear pharmacokinetics were observed in healthy volunteers after single dose administration up to 250 micrograms/kg.
Croatian: Nakon primjene jednokratne doze do 250 mikrograma/kg u zdravih je dobrovoljaca primijećena skoro linearna farmakokinetika proporcionalna dozi.
English: Median (25th, 75th percentile) days of Median (25th, 75th percentile) days of
Croatian: Medijan (25., 75. percentila) dana oralnog mukozitisa stupnja 3/4 prema ljestvici
English: Patient Incidence of Febrile Neutropenia 92% 75% * Using Cochran-Mantel-Haenszel (CMH) test stratified for study centre.
Croatian: * Primjena testa Cochran-Mantel-Haenszel stratificiranog prema ispitivačkom centru.
English: • skin rash, itching and redness (pruritus and erythaema);
Croatian: • osip, svrbež i crvenilo kože (pruritus ili eritem);
English: The study included three treatment arms and was designed to compare each of the palifermin arms (pre- and pre/post-) to
Croatian: Ispitivanje je uključivalo 3 terapijske skupine s ciljem uspoređivanja skupina koje su primale palifermin (prije i prije/nakon kemoterapije) sa skupinom koja je primala placebo.
English: Pregnancy and breast-feeding
Croatian: 4.6 Plodnost, trudnoća i dojenje
English: After single intravenous doses of 20 to 250 micrograms/kg (healthy volunteers) and 60 micrograms/kg (cancer patients), palifermin exhibited rapid extravascular distribution In patients with haematological malignancies mean Vss was 5 l/kg and mean clearance about 1300 ml/hour/kg with an average terminal half-life of approximately 4.5 hours.
Croatian: Nakon primjene jednokratne intravenske doze od 20 do 250 mikrograma/kg (zdravi dobrovoljci) i 60 mikrograma/kg (oboljeli od malignih bolesti), ekstravaskularna distribucija palifermina bila je brza.
English: Palifermin works in the same way as keratinocyte growth factor (KGF) which is made naturally by
Croatian: Palifermin djeluje na isti način kao i čimbenik rasta keratinocita koji Vaše tijelo prirodno stvara u malim količinama.
English: Visually inspect the solution for discolouration and particulate matter before administration.
Croatian: Prije primjene vizualno pregledajte otopinu na promjenu boje i prisutnost čestica.
English: • lip swelling.
Croatian: Escherichia coli.
English: NAME OF THE MEDICINAL PRODUCT Kepivance 6.25 mg powder for solution for injection Palifermin
Croatian: Kepivance 6,25 mg prašak za otopinu za injekciju palifermin
English: Lip swelling, eyelid oedema
Croatian: Oticanje usana, otok vjeđa
English: The efficacy results are presented
Croatian: NAVOĐENJE DJELATNE/IH
English: Days
Croatian: Djeca
English: Caution should be used when dosing patients with hepatic impairment.
Croatian: Pri doziranju u bolesnika s oštećenjem funkcije jetre potreban je oprez.
English: • eyelid swelling;
Croatian: • opće oticanje (edem);
English: NAME OF THE MEDICINAL PRODUCT Kepivance 6.25 mg powder for solution for injection
Croatian: Kepivance 6,25 mg prašak za otopinu za injekciju
English: This dose will be given to you as an intravenous injection (into a vein).
Croatian: Tu ćete dozu primiti injekcijom u venu.
English: Dose-dependent epithelial cell proliferation was observed 48 hours post-dosing in healthy subjects given single intravenous doses of 120 to 250 micrograms/kg.
Croatian: U zdravih ispitanika koji su primili jednokratne intravenske doze od 120
English: Adverse reactions
Croatian: Način primjene
English: Sucrose
Croatian: EXP
English: No adverse developmental effects were observed in rats and rabbits at doses of up to 300 and 60 micrograms/kg/day, respectively.
Croatian: Pri dozama do 300 mikrograma/kg/dan za štakore i do 60 mikrograma/kg/dan za kuniće nisu primijećeni štetni učinci na razvoj.
English: Detailed information on this medicinal product is available on the website of the European Medicines
Croatian: Detaljnije informacije o ovom lijeku dostupne su na web stranici Europske agencije za lijekove. http://www.ema.europa.eu.
English: None were considered serious in nature.
Croatian: Nijedan takav slučaj nije se smatrao ozbiljnim po prirodi.
English: For single use only.
Croatian: Isključivo za jednokratnu upotrebu.
English: Treatment can then continue with the next scheduled dose as planned.
Croatian: Liječenje se tada može nastaviti sljedećom dozom kao što je planirano.
English: - Contact a doctor immediately.
Croatian: Odmah se obratite liječniku.
English: This is normal and will not affect your dose.
Croatian: To je normalno i neće utjecati na dozu
English: open here
Croatian: otvoriti ovdje
English: - Contact a doctor for advice.
Croatian: Obratite se liječniku za savjet.
English: These symptoms are not really flu, see below.
Croatian: Ovi simptomi nisu stvarna gripa, pogledajte niže.
English: Research Triangle Park, NC 27709-4627 USA
Croatian: Research Triangle Park, NC 27709-4627 SAD
English: 17% previously treated
Croatian: 17% prethodno liječeni
English: - If you have severe depression or think about committing suicide.
Croatian: - ako patite od teške depresije ili razmišljate o samoubojstvu
English: 47% ≥2 relapses in prior year
Croatian: 47% ≥2 relapsa u prethodnoj godini
English: 250 Binney Street Cambridge, MA 02142 USA
Croatian: 250 Binney Street Cambridge, MA 02142 SAD
English: See section 4 for the symptoms of an allergic reaction.
Croatian: Pogledajte dio 4 za simptome alergijske reakcije.
English: - Thoughts about committing suicide
Croatian: - razmišljate o samoubojstvu
English: Plegridy is not to be used in children and adolescents below 18 years old.
Croatian: Plegridy se ne smije koristiti u djece i adolescenata mlađih od 18 godina.
English: Results for this study are shown in Table 3.
Croatian: Rezultati tog ispitivanja prikazani su u tablici 3.
English: See section 6.3 for additional information on storage at room temperature.
Croatian: Vidjeti dio 6.3 za dodatne informacije o čuvanju na sobnoj temperaturi.
English: Results in this subgroup were consistent with those in the overall population.
Croatian: Rezultati su u toj podskupini bili u skladu s onima u cjelokupnoj populaciji.
English: Results in this subgroup were numerically consistent with those in the overall population but not statistically significant.
Croatian: Rezultati su u toj podskupini bili numerički u skladu s onima u cjelokupnoj populaciji, ali ne statistički značajni.
English: You will hear the clicking sounds start.
Croatian: Začut ćete zvuk otkucavanja.
English: Mean age (years)
Croatian: Srednja dob (godine)
English: Do not make changes unless your doctor tells you.
Croatian: Nemojte mijenjati način liječenja, osim ako Vam liječnik odredi drugačije.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, especially those used to treat epilepsy or depression.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, osobito one koji se koriste za liječenje epilepsije ili depresije.
English: Neutralising antibodies have the potential to reduce clinical efficacy.
Croatian: Neutralizirajuća protutijela imaju potencijal smanjiti kliničku djelotvornost.
English: Throw away any Plegridy that is accidentally frozen.
Croatian: Bacite Plegridy koji je bio slučajno zamrznut.
English: If you use more Plegridy than you should
Croatian: Ako primijenite više Plegridyja nego što ste trebali
English: This includes any medicines obtained without a prescription.
Croatian: To uključuje i svaki lijek koji ste nabavili bez recepta.
English: *Dosed every 2 weeks (14 days)
Croatian: *Dozirano svaka 2 tjedna (14 dana)
English: The pack contains 3 inner cartons.
Croatian: Pakiranje sadrži 3 unutarnje kutije.
English: You can inject Plegridy yourself without the help of your doctor, if you have been trained how to do this.
Croatian: Injekciju Plegridyja možete sebi dati sami, bez pomoći liječnika, ako ste podučeni kako to raditi.
English: The validity of extrapolating these non-clinical data to humans is unknown.
Croatian: Nije poznato vrijedi li ekstrapolacija ovih nekliničkih podataka na ljude.
English: Date of first authorisation: 18 July 2014 Date of latest renewal: 25 March 2019
Croatian: Datum posljednje obnove odobrenja: 25. ožujka 2019
English: This medicine is used to treat relapsing-remitting multiple sclerosis (MS) in adults aged 18 or over.
Croatian: Ovaj lijek se koristi za liječenje relapsno remitirajuće multiple skleroze (MS) u odraslih osoba u dobi od 18 godina i više.
English: Time*
Croatian: Vrijeme*
English: Clinical experience in patients aged above 65 years is limited.
Croatian: Starije osobe Kliničko iskustvo s bolesnicima u dobi iznad 65 godina je ograničeno.
English: The average molecular mass is approximately 44 kDa of which the protein moiety constitutes approximately 23 kDa.
Croatian: Prosječna molekularna masa približno je 44 kDa od čega proteinski dio zauzima približno 23 kDa.
English: The primary endpoint was the annualised relapse rate (ARR) over 1 year.
Croatian: Primarni ishod bila je godišnja stopa recidiva (engl. annualised relapse rate, ARR) tijekom 1 godine.
English: Do not touch, clean, or manipulate the needle cover.
Croatian: Nemojte dirati, čistiti ili namještati pokrov igle.
English: Amount (micrograms)
Croatian: Količina (mikrogrami)
English: Decreases in white blood cell counts were not associated with an increased risk of infections or serious infections.
Croatian: Smanjenje broja bijelih krvnih stanica nije bilo povezano s povećanim rizikom od infekcije ili ozbiljnih infekcija.
English: 125 (full dose)
Croatian: 125 (puna doza)
English: Clear and colourless solution with pH 4.5-5.1.
Croatian: Bistra i bezbojna otopina s pH 4,5-5,1.
English: Interferons are natural substances made in the body to help protect from infections and diseases.
Croatian: Interferoni su prirodne tvari koje nastaju u tijelu kako bi pomogle zaštiti od infekcija i bolesti.
English: Collect all the supplies you will need to give yourself or to receive an injection.
Croatian: Prikupite sav pribor koji ćete trebati da sami sebi date ili da primite injekciju.
English: - Your doctor may still prescribe Plegridy for you, but it's important to let your doctor know if you have had depression or any similar problems affecting your mood in the past.
Croatian: - Moguće je da će Vam liječnik propisati Plegridy, ali važno je da liječniku kažete da ste u prošlosti patili od depresije ili bilo kojeg drugog sličnog problema koji utječe na Vaše raspoloženje.
English: 92% ≥9 T2 lesions baseline 16% EDSS ≥4
Croatian: 92% ≥9 T2 lezija na početku 16% EDSS ≥4
English: If you are new to Plegridy, your doctor may advise you to gradually increase your dose so that you can adjust to the effects of Plegridy before taking the full dose.
Croatian: Ako ste novi u liječenju Plegridyjem, liječnik Vam može savjetovati da postupno povećavate dozu tako da se možete prilagoditi učincima Plegridyja prije nego što primite punu dozu.
English: If you do miss your usual day, inject as soon as you can and carry on as usual.
Croatian: Ako propustite svoj uobičajeni dan, ubrizgajte lijek čim prije možete i nastavite kao i obično.
English: However, do not inject more than once in a 7-day period.
Croatian: Međutim, nemojte ubrizgati lijek više od jednom u roku od 7 dana.
English: First injection:
Croatian: Prva injekcija:
English: Everyone has their own set of MS symptoms.
Croatian: Svatko ima svoju skupinu simptoma multiple skleroze.
English: Sometimes you will need to remind other healthcare professionals that you are being treated with Plegridy.
Croatian: Ponekad ćete trebati podsjetiti i ostale zdravstvene radnike da se liječite Plegridyjem.
English: Pre-filled syringes/pre-filled pens are for single use only and should be discarded after use.
Croatian: Napunjene štrcaljke / napunjene brizgalice namijenjene su samo za jednokratnu upotrebu i treba ih baciti nakon upotrebe.
English: Patients who failed previous MS treatment were not included in the study.
Croatian: Bolesnici čije liječenje nije uspjelo u prethodnoj MS terapiji nisu bili uključeni u ispitivanje.
English: 38% at least 1 Gd+ lesion at baseline
Croatian: 38% s najmanje 1 Gd+ lezijom na početku
English: • If 7 days or more to the next planned dose: Patients should administer their missed dose immediately.
Croatian: • Ako ima 7 dana ili više do sljedeće planirane doze: Bolesnici trebaju odmah primijeniti svoju propuštenu dozu.
English: If you do not hear clicking sounds or you do not see green ticks in the injection status window after attempting to inject, the pen may have locked and you may not have received your injection.
Croatian: Ako ne čujete zvuk otkucavanja ili ne vidite zelene kvačice u prozorčiću stanja injekcije nakon pokušaja davanja injekcije, možda se brizgalica zaključala i niste primili svoju injekciju.
English: This can help to reduce the number of relapses that you have and slow down the disabling effects of MS.
Croatian: To može pomoći u smanjenju broja Vaših relapsa i usporiti onesposobljavajući učinak multiple skleroze.
English: Other medicines and Plegridy
Croatian: Drugi lijekovi i Plegridy
English: Day 28
Croatian: 28. dan
English: The study design and patient demographics are presented in Table 2.
Croatian: Ustroj ispitivanja i demografski podaci bolesnika prikazani su u tablici 2.
English: Results over 2 years confirmed that efficacy was maintained beyond the placebo controlled first year of the study.
Croatian: Rezultati tijekom 2 godine potvrdili su da je djelotvornost održana i nakon placebom kontrolirane prve godine ispitivanja.
English: For example, if you are prescribed other medicines, or if you have a blood test. Plegridy may affect the other medicines or the test result.
Croatian: Na primjer, ako su Vam propisani drugi lijekovi ili ako radite krvne pretrage, Plegridy može utjecati na druge lijekove ili na rezultate pretraga.
English: • Recommended storage is controlled refrigeration 2°C to 8°C in the closed original carton to protect from light.
Croatian: • Preporučuje se čuvanje u hladnjaku na kontroliranoj temperaturi od 2°C do 8°C u zatvorenoj originalnoj kutiji radi zaštite od svjetlosti.
English: b. Check the medicine window.
Croatian: b. Provjerite prozorčić za lijek.
English: - Patients with current severe depression and/or suicidal ideation (see sections 4.4 and 4.8).
Croatian: - Bolesnici koji trenutno boluju od teške depresije i/ili imaju suicidalne ideacije (vidjeti dijelove 4.4 i 4.8).
English: Decreased peripheral blood counts
Croatian: Smanjenje broja perifernih krvnih stanica
English: On average, flu-like symptoms begin approximately 10 hours after injection and last between 12 and 24 hours.
Croatian: U prosjeku, simptomi nalik gripi počinju otprilike 10 sati poslije injekcije i traju između 12 i 24 sata.
English: • Record the date and location of each injection.
Croatian: • Zabilježite datum i mjesto svake injekcije.
English: The safety and efficacy of Plegridy in children and adolescents aged 0 to 18 years have not been established in multiple sclerosis.
Croatian: Sigurnost i djelotvornost Plegridyja u djece i adolescenata u dobi od 0 do 18 godina nisu ustanovljene u multiploj sklerozi.
English: The Initiation Pack contains your first two injections to gradually adjust your dose.
Croatian: Pakiranje za početak liječenja sadrži Vaše prve dvije injekcije za postupno podešavanje doze.
English: HR: Hazard ratio
Croatian: HR (Hazard Ratio): Omjer hazarda
English: Do not use two injections to make up for a missed injection.
Croatian: Nemojte primijeniti dvije injekcije kako biste nadoknadili propuštenu injekciju.