FrancophonIA/ELRC3.0 huggingface dataset:
English: The recommended minimum dose of allopurinol is 300 mg, or 200 mg for patients with moderate renal impairment (creatinine clearance [CrCL] of 30-59 mL/min).
Danish: Den anbefalede minimaldosis af allopurinol er 300 mg, eller 200 mg til patienter med moderat nedsat nyrefunktion (kreatininclearance [CrCL] 30-59 ml/min).
English: Do not take Zurampic: - if you are allergic to lesinurador any of the other ingredients of this medicine (listed in section
Danish: Tag ikke Zurampic: - hvis du er allergisk over for lesinurad eller et af de øvrige indholdsstoffer i Zurampic (angivet i punkt 6).
English: Based on its mechanism of action, lesinurad may not be effective in these patients (see section 5.1).
Danish: Baseret på lesinurads virkningsmekanisme er det ikke nødvendigvis effektivt hos disse patienter (se pkt.
English: What you need to know before you take Zurampic
Danish: Det skal du vide, før du begynder at tage Zurampic
English: The recommended dose is 1 tablet of 200 mg once a day in the morning.
Danish: Den anbefalede dosis er 1 tablet på 200 mg én gang dagligt om morgenen.
English: Therefore, it is recommended that Zurampic should be used with caution in patients taking moderate inhibitors of CYP2C9.
Danish: Derfor anbefales det, at Zurampic anvendes med forsigtighed til patienter, der tager moderate CYP2C9-hæmmere.
English: The population pharmacokinetic analysis of clinical data in gout patients treated for up to 12 months estimated increases in lesinurad exposure of approximately 12%, 31% and 65% in patients with mild, moderate, and severe renal impairment, respectively, compared with patients with normal renal function.
Danish: Den populationsfarmakokinetiske analyse af kliniske data hos patienter med urinsyregigt behandlet i op til 12 måneder estimerede stigning i lesinuradeksponeringen på ca. 12 %, 31 % og 65 % hos patienter med henholdsvis let, moderat og svært nedsat nyrefunktion, sammenlignet med patienter med normal nyrefunktion.
English: If treatment with the xanthine oxidase inhibitor is interrupted, Zurampic dosing must also be interrupted.
Danish: Hvis behandlingen med xanthinoxidasehæmmeren afbrydes, skal behandlingen med Zurampic også afbrydes.
English: If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking Zurampic.
Danish: Hvis noget af ovenstående gælder for dig (eller hvis du er i tvivl), skal du tale med lægen eller apotekspersonalet, inden du tager Zurampic.
English: Mean sUA reductions following Zurampic 200 mg administration alone were approximately 46% and 26% at 6 hours and 24 hours post-dose, respectively.
Danish: Gennnemsnitlig sUA-reduktion efter administration af Zurampic 200 mg alene var ca. 46 % og 26 % henholdsvis 6 timer og 24 timer efter dosering.
English: Additional monitoring of lipids and blood pressure is recommended in patients using sensitive CYP3A substrate lipid lowering medicines (such as lovastatin or simvastatin) or antihypertensive medicines (such as amlodipine, felodipine or nisoldipine), since their efficacy may be reduced (see section 4.5).
Danish: Yderligere monitorering af lipider og blodtryk anbefales hos patienter, som tager lipidsænkende lægemidler, der er sensitive CYP3A-substrater (såsom lovastatin eller simvastatin) eller antihypertensiv medicin (såsom amlodipin, felodipin eller nisoldipin), da deres effekt kan blive nedsat (se pkt.
English: In clinical trials, most adverse reactions were mild or moderate in intensity and resolved while continuing Zurampic therapy.
Danish: I de kliniske studier var de fleste bivirkninger lette eller moderate i intensitet og forsvandt ved fortsat Zurampicbehandling.
English: How Zurampic works:
Danish: Zurampic indeholder:
English: The lack of an observed interaction could be due to the combination of the induction of CYP2C9 and inhibition of OATP1B1 and 1B3.
Danish: Manglen på en observeret interaktion kunne skyldes kombinationen af CYP2C9induktion og OATP1B1- og 1B3-hæmning.
English: Gout is a type of arthritis caused by an accumulation of urate crystals around the joints.
Danish: Urinsyregigt er en type leddegigt, der skyldes en ophobning af uratkrystaller omkring leddene.
English: Wait and take your next dose of Zurampic with your next morning dose of allopurinol or febuxostat.
Danish: Vent og tag din næste dosis af Zurampic med din næste morgendosis af allopurinol eller febuxostat.
English: Do not use this medicine after the expiry date which is stated on the carton or blister foil after “EXP”.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på pakningen eller blisterfolien efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Fluconazole, a moderate CYP2C9 inhibitor, increased lesinurad AUC (56%) and Cmax (38%), as well as the amount of lesinurad excreted unchanged in urine.
Danish: Fluconazol, som er en moderat CYP2C9-hæmmer, øgede lesinurad-AUC (56 %) og -Cmax (38 %) samt den mængde lesinurad, der blev udskilt uomdannet i urinen.
English: Uncommon - may affect up to 1 in 100 people - kidney stones, - dehydration (loss of too much fluid from your body).
Danish: Ikke almindelig - kan forekomme hos op til 1 ud af 100 personer - nyresten, - dehydrering (tab af for meget væske fra kroppen).
English: Based on interaction studies in healthy subjects or gout patients, Zurampic does not have clinically significant interactions with NSAIDs (naproxen and indomethacin), colchicine, repaglinide, tolbutamide, febuxostat or allopurinol.
Danish: På baggrund af interaktionsstudier hos raske forsøgspersoner eller patienter med urinsyregigt har Zurampic ikke klinisk signifikante interaktioner med NSAID (naproxen og indomethacin), colchicin, repaglinid, tolbutamid, febuxostat eller allopurinol.
English: Rare cases of hypersensitivity (photodermatosis, photosensitivity reaction, dermatitis allergic, pruritus and urticaria) have been reported with lesinurad during the clinical programme.
Danish: Der er rapporteret sjældne tilfælde af overfølsomhed (fotodermatit, fotosensibilitetsreaktion, allergisk dermatit, pruritus og urticaria) med lesinurad i det kliniske program.
English: There was no apparent influence of the fat content in the meal on the pharmacokinetics of lesinurad.
Danish: Fedtindholdet i måltidet havde tilsyneladende ingen indvirkning på lesinurads farmakokinetik.
English: Zurampic 200 mg tablets are available in clear blisters in pack sizes of 10, 28, 30 or 98 non-perforated blisters and 100 x 1 perforated unit dose blisters.
Danish: Zurampic 200 mg tabletter fås i klare blisterpakninger i pakningsstørrelser på 10, 28, 30 eller 98 ikkeperforerede blisterpakninger og 100 x 1 perforerede enkeltdosisblisterpakninger.
English: The possibility of reduced efficacy of concomitant medicinal products that are CYP3A substrates should be considered and their efficacy (e.g. blood pressure and cholesterol levels) should be monitored (see section 4.4).
Danish: Det skal tages i betragtning, at der er mulighed for nedsat effekt af samtidige lægemidler, der er CYP3A-substrater, og deres effekt (fx blodtryk og kolesterolniveau) skal monitoreres (se pkt.
English: Salicylates at doses higher than 325 mg per day may decrease the serum uric acid lowering activity of lesinurad and should not be co-administered with Zurampic.
Danish: Salicylater i doser over 325 mg pr. dag kan reducere lesinurads serumurinsyresænkende aktivitet og bør ikke administreres sammen med Zurampic.
English: The primary efficacy endpoint in both CLEAR1 and CLEAR2 was the proportion of patients achieving a serum uric acid target level of less than 6 mg/dL by Month 6.
Danish: Det primære effektendepunkt i både CLEAR1 og CLEAR2 var andelen af patienter, der nåede et målniveau for serumurinsyre på under 6 mg/dl ved Måned 6.
English: Common - may affect up to 1 in 10 people - flu (influenza), - headache, - increase in the amount of creatinine in your blood -shown in tests, - heartburn(acid reflux).
Danish: Almindelig - kan forekomme hos op til 1 ud af 10 personer - influenza, - hovedpine, - forhøjet indhold af kreatinin i blodet - kan ses i prøver, - halsbrand (sure opstød).
English: The recommended dose of Zurampic is 200 mg once daily in the morning.
Danish: Den anbefalede dosis af Zurampic er 200 mg én gang dagligt om morgenen.
English: Zurampic slightly decreased exposure of oxypurinol (a URAT1 substrate), the major metabolite of allopurinol; however, the uric acid-lowering effect of the combination with allopurinol was significantly greater than for either substance alone.
Danish: Zurampic medførte en let nedsat eksponering for oxypurinol (et URAT1-substrat), hovedmetabolitten af allopurinol; dog var den urinsyrenedsættende virkning af kombinationen med allopurinol signifikant større end for de enkelte stoffer alene.
English: Zurampic is not recommended in patients with unstable angina, New York Heart Association (NYHA) class III or IV heart failure, uncontrolled hypertension or with a recent event of myocardial infarction, stroke, or deep venous thrombosis within the last 12 months, due to insufficient data.
Danish: På grund af utilstrækkelige data frarådes Zurampic til patienter med ustabil angina, New York Heart Association (NYHA)-klasse III eller IV hjertesvigt, ukontrolleret hypertension, med en nylig episode af myokardieinfarkt eller apopleksi eller med dyb venetrombose inden for de foregående 12 måneder.
English: Zurampic must never be taken without a ‘xanthine oxidase inhibitor' medicine.
Danish: Zurampic må aldrig tages uden en xanthinoxidasehæmmer.
English: Patients should be informed that failure to follow these instructions may increase the risk of renal events (see section 4.4).
Danish: Patienterne skal informeres om, at manglende efterlevelse af disse instruktioner kan øge risikoen for nyrepåvirkninger (se pkt.
English: Zurampic contains the active ingredient lesinurad and is used to treat gout in adult patients by lowering the levels of uric acid in the blood.
Danish: Zurampic indeholder det aktive stof lesinurad og anvendes til behandling af urinsyregigt hos voksne patienter, idet det nedsætter indholdet af urinsyre i blodet.
English: Experience with Zurampic in patients with an estimated CrCL (eCrCL) less than 45 mL/min is limited; therefore, Zurampic should be used with caution in patients with a CrCL from 30 mL/min to less than 45 mL/min.
Danish: Der er begrænset erfaring med Zurampic hos patienter med en estimeret CrCL (eCrCL) under 45 ml/min; Zurampic skal derfor anvendes med forsigtighed til patienter med CrCL fra 30 ml/min til < 45 ml/min.
English: Lesinurad also inhibits OAT4, a uric acid transporter involved in diuretic-induced hyperuricaemia.
Danish: Lesinurad hæmmer også OAT4, en urinsyretransportør, der er involveret i diuretikainduceret hyperurikæmi.
English: Secondary hyperuricaemia
Danish: Sekundær hyperurikæmi
English: This is due to reduction in serum uric acid levels resulting in mobilisation of urate from tissue deposits.
Danish: Dette skyldes det nedsatte serumurinsyreniveau, som medfører mobilisering af urat fra vævsdepoter.
English: In the fed state, after a single dose of lesinurad 200 mg, geometric mean lesinurad Cmax and AUC were 6 μg/mL and 29 μg/hr/mL, respectively.
Danish: Efter en enkelt dosis lesinurad på 200 mg i forbindelse med fødeindtagelse var den geometriske middelværdi af Cmax og AUC henholdsvis 6 μg/ml og 29 μg/t/ml.
English: Zurampic should not be initiated in kidney transplant recipients.
Danish: Zurampic må ikke påbegyndes hos nyretransplanterede patienter.
English: In addition, lesinurad is an in vitro inducer of CYP2B6 and CYP3A via CAR/PXR.
Danish: Derudover inducerer lesinurad CYP2B6 og CYP3A via CAR/PXR in vitro.
English: The target serum uric acid level is less than 6 mg/dL (360 µmol/L).
Danish: Det tilstræbte serumurinsyreniveau er under 6 mg/dl (360 µmol/l).
English: Testing for the target serum uric acid level may be performed as early as 4 weeks after initiating Zurampic treatment.
Danish: Der kan allerede udføres test af serumurinsyre 4 uger efter behandlingsstart med Zurampic.
English: Pack size of 100 x 1 film-coated tablet in perforated unit dose blisters.
Danish: Pakningsstørrelse a 100 x 1 filmovertrukket tablet i perforerede enkeltdosisblistere.
English: The most commonly reported adverse reactions during treatment with Zurampic 200 mg are influenza, gastro-oesophageal reflux disease, headache and blood creatinine increased.
Danish: De hyppigst indberettede bivirkninger under behandling med Zurampic 200 mg er influenza, gastroøsofageal reflukssygdom, hovedpine og forhøjet kreatinin i blodet.
English: Rifampin
Danish: Rifampicin
English: --o-- Placebo + Allopurinol,
Danish: Behandlingsgruppe: --o-- Placebo + allopurinol,
English: Mean (SE) Serum Uric Acid (mg/dL)
Danish: Gennemsnitlig (SE) urinsyre i serum (mg/dl)
English: The serious adverse reactions renal failure, renal impairment and nephrolithiasis have occurred uncommonly (less than 1 case per 100 patients) (see Table 1).
Danish: De alvorlige bivirkninger nyresvigt, nedsat nyrefunktion og nyresten forekom med hyppigheden ”ikke almindelig” (mindre end 1 tilfælde pr. 100 patienter) (se Tabel 1).
English: HMG-CoA reductase inhibitors that are sensitive CYP3A substrates may interact with lesinurad.
Danish: HMG-CoA-reduktasehæmmere, der er sensitive CYP3A-substrater, kan interagere med lesinurad.
English: In the long-term uncontrolled extension trials, the rates of gout flares requiring treatment further decreased in the 60% of subjects who entered the extension studies and continued treatment with Zurampic 200 mg in combination with allopurinol or febuxostat for up to an additional year of treatment.
Danish: I de ukontrollerede forlængelsesstudier var forekomsten af behandlingskrævende udbrud af urinsyregigt lav og blev yderligere reduceret hos de 60 % af forsøgspersonerne, som deltog i forlængelsesstudierne og fortsatte behandlingen med Zurampic 200 mg i kombination med allopurinol eller febuxostat i op til et år ekstra.
English: All patients with a Major Adverse Cardiovascular Event treated with Zurampic 200 mg had a history of heart failure, stroke or myocardial infarction.
Danish: Alle patienter, der fik en alvorlig kardiovaskulær bivirkning i forbindelse med behandling med Zurampic 200 mg, havde hjertesvigt, apopleksi eller myokardieinfarkt i anamnesen.
English: Pharmacotherapeutic group: Antigout preparations, preparations increasing uric acid excretion ATC code: M04AB05
Danish: Farmakoterapeutisk klassifikation: Midler mod artritis urica, midler, der øger urinsyreudskillelsen, ATC-kode: M04AB05
English: Effect of other medicinal products on lesinurad
Danish: Andre lægemidlers virkning på lesinurad:
English: Rifampin, an inhibitor of OATPs and an inducer of CYP2C9, decreased lesinurad exposure and slightly reduced the amount of lesinurad excreted unchanged in urine with no clinically relevant effect.
Danish: Rifampin, en hæmmer af OATP'er og en CYP2C9-induktor, formindskede lesinurad-eksponeringen og reducerede mængden af lesinurad, der udskiltes uomdannet i urinen, en anelse uden nogen klinisk relevant effekt.
English: If you stop taking Zurampic Do not stop taking Zurampic without the advice of your doctor even if you feel better.
Danish: Du må ikke stoppe med at tage Zurampic, uden at din læge har rådgivet dig.
English: Failure to follow these instructions may increase the risk of kidney side effects (see section 4).
Danish: Hvis du ikke følger disse anvisninger, kan du øge risikoen for problemer med nyrerne (se punkt 4).
English: Rare - may affect up to 1 in 1000 people - skin reactions, including redness, itchy skin, lumpy rash (hives) and skin rash on exposure to sunshine.
Danish: Sjælden - kan forekomme hos op til 1 ud af 1.000 personer - hudreaktioner, herunder rødme, kløende hud, udslæt med hævelse (nældefeber) og udslæt på huden ved udsættelse for solskin.
English: By inhibiting URAT1, lesinurad increases uric acid excretion and thereby lowers serum uric acid (sUA).
Danish: Ved at hæmme URAT1 øger lesinurad urinsyreudskillelsen og nedsætter derfor serumurinsyre (sUA).
English: Table 2 Proportion of patients who achieved target serum uric acid levels (<6mg/dL) with Zurampic in combination with allopurinol - Pooled data from CLEAR1 and CLEAR2 studies
Danish: Tabel 2 Andel af patienter, som nåede det ønskede målniveau for serumurinsyre (<6 mg/dl) med Zurampic i kombination med allopurinol - Puljede data fra CLEAR1- og CLEAR2-studierne
English: You must use Zurampic together with either allopurinol or febuxostat.
Danish: Du skal bruge Zurampic sammen med enten allopurinol eller febuxostat.
English: Lesinurad is a selective uric acid reabsorption inhibitor that inhibits uric acid transporter URAT1.
Danish: Lesinurad er en selektiv urinsyrereabsorptionshæmmer, der hæmmer urinsyretransportøren URAT1.
English: A causal relationship with Zurampic has not been established.
Danish: Det er ikke fastslået, om der er kausal sammenhæng med Zurampic.
English: Lesinurad is a mild to moderate inducer of CYP3A and therefore may lower plasma concentrations of some hormonal contraceptives, thereby decreasing contraceptive effectiveness (see sections 4.4 and
Danish: Lesinurad er en let til moderat CYP3A-induktor og kan derfor nedsætte plasmakoncentrationen af nogle hormonelle præventionsmidler, hvorved den præventive virkning kan nedsættes (se pkt.
English: Based on pharmacokinetic modelling simulations, patients with moderate renal impairment and reduced CYP2C9 activity (co-administration of a CYP2C9 inhibitor or a CYP2C9 poor metabolizer) are predicted to have an increase in AUC of approximately 200% in comparison to normal renal function and unimpaired CYP2C9 activity.
Danish: På baggrund af farmakokinetiske modelsimulationer forudsiges patienter med moderat nedsat nyrefunktion og reduceret CYP2C9-aktivitet (samtidig administration af en CYP2C9-hæmmer eller hos en langsom CYP2C9omsætter) at have en stigning i AUC på ca. 200 % sammenlignet med en person med normal nyrefunktion og ikke-nedsat CYP2C9-aktivitet.
English: Patients known to be CYP2C9 poor metabolisers should be treated with caution, as the potential risk of renal-related adverse effects may be increased (see sections 4.8 and 5.2).
Danish: Patienter, der er konstateret at være langsomme CYP2C9-omsættere, skal behandles med forsigtighed, da den potentielle risiko for nyrerelaterede bivirkninger kan være øget (se pkt.
English: The medicine is still working to lower uric acid.
Danish: Medicinen virker stadig og nedsætter indholdet af urinsyre.
English: However, the in vivo activity of OATP1B1, OAT1, OAT3 and OCT1 was not affected by lesinurad.
Danish: In vivo-aktiviteten af OATP1B1, OAT1, OAT3 og OCT1 blev imidlertid ikke påvirket af lesinurad.
English: When Zurampic 200 mg was added to a xanthine oxidase inhibitor (i.e. febuxostat), additional 25% and 19% of sUA reductions were observed at 6 hours and 24 hours post-dose, respectively.
Danish: Når Zurampic 200 mg blev administreret sammen med en xanthinoxidasehæmmer (febuxostat) blev der observeret yderligere reduktioner i sUA på 25 % og 19 % henholdsvis 6 timer og 24 timer efter dosering.
English: The most frequent renal-related adverse reaction was blood creatinine increased (4.3% with Zurampic 200 mg and 7.8% with Zurampic 400 mg compared to 2.3% with placebo).
Danish: De hyppigste nyrerelaterede bivirkninger var forhøjet blodkreatinin (4,3 % med Zurampic 200 mg og 7,8 % med Zurampic 400 mg sammenlignet med 2,3 % med placebo).
English: Failure to follow these instructions may increase the risk of kidney side effects.
Danish: Hvis du ikke følger disse anvisninger, kan du øge risikoen for problemer med nyrerne.
English: Zurampic, in combination with a xanthine oxidase inhibitor, is indicated in adults for the adjunctive treatment of hyperuricaemia in gout patients (with or without tophi) who have not achieved target serum uric acid levels with an adequate dose of a xanthine oxidase inhibitor alone.
Danish: Zurampic er, i kombination med en xanthinoxidasehæmmer, indiceret hos voksne til tillægsbehandling af hyperurikæmi hos patienter med urinsyregigt (med eller uden tofi), som ikke har opnået det tilstræbte serumurinsyreniveau med en optimal dosis af en xanthinoxidasehæmmer alene.
English: No dose adjustment is necessary in patients with mild or moderate hepatic impairment (Child-Pugh classes A and B) (see section 5.2).
Danish: Dosisjustering er ikke nødvendig hos patienter med let til moderat nedsat leverfunktion (Child-Pugh klasse A og B) (se pkt.
English: Clinical outcomes - gout flares requiring treatment The rates of gout flare requiring treatment were low and comparable to placebo in the last 6 months of the randomised trials (after gout flare prophylaxis was discontinued) with median scores of zero.
Danish: Kliniske resultater - behandlingskrævende udbrud af urinsyregigt Forekomsten af behandlingskrævende udbrud af urinsyregigt var lav og sammenlignelig med placebo i de sidste 6 måneder af de randomiserede studier (efter seponering af urinsyregigtprofylakse) med medianscoren nul.
English: Treatment with lesinurad 200 mg in combination with a xanthine oxidase inhibitor was associated with an increased incidence of serum creatinine elevations, which are related to increased renal uric acid excretion.
Danish: Behandling med lesinurad 200 mg i kombination med en xanthinoxidasehæmmer er associeret med en øget forekomst af forhøjet serumkreatinin, som er forbundet med øget renal udskillelse af urinsyre.
English: Effect of lesinurad on other medicinal products
Danish: Lesinurads virkning på andre lægemidler:
English: Figure 1 Mean serum uric acid levels in pooled clinical studies with Zurampic in combination with allopurinol in patients with inadequate response (sUA ≥6 mg/dL) to allopurinol alone
Danish: Figur 1 Gennemsnitlige serumurinsyreniveauer i puljede kliniske studier med Zurampic i kombination med allopurinol hos patienter med utilstrækkeligt respons (sUA ≥6 mg/dl) på allopurinol alene
English: Table 1 lists adverse reactions identified in clinical studies with patients receiving Zurampic 200 mg once daily in combination with a xanthine oxidase inhibitor, allopurinol or febuxostat.
Danish: Tabel 1 viser de bivirkninger, der er identificeret i kliniske studier med patienter, som fik Zurampic 200 mg én gang dagligt i kombination med en xanthinoxidasehæmmer, allopurinol eller febuxostat.
English: At the 400 mg dose, when compared with extensive CYP2C9 metabolisers (CYP2C9 *1/*1 [N=41]), increased lesinurad exposures were observed in intermediate CYP2C9 metabolisers (CYP2C9 *1/*3 [N=4], approximately 22% increase in AUC) and in poor CYP2C9 metabolisers (CYP2C9 *3/*3 [N=1], approximately 111% increase in AUC) accompanied with higher lesinurad renal excretion.
Danish: Ved en dosis på 400 mg og sammenlignet med ekstensive CYP2C9-omsættere (CYP2C9 *1/*1[N=41]) blev der observeret højere lesinuradeksponering hos intermediære CYP2C9-omsættere (CYP2C9 *1/*3 [N=4], ca. 22 % stigning i AUC) og hos langsomme CYP2C9-omsættere (CYP2C9 *3/*3 [N=1], ca. 111 % stigning i AUC) ledsaget af højere renal udskillelse af lesinurad.
English: Atropisomer 1 is extensively metabolised by CYP2C9 whereas atropisomer 2 is minimally metabolised by both CYP2C9 and CYP3A4.
Danish: Atropisomer 1 metaboliseres i udstrakt grad af CYP2C9, hvorimod atropisomer 2 metaboliseres minimalt af både CYP2C9 og CYP3A4.
English: Clinical outcomes - tophus resolution and reduction In CRYSTAL, the proportion of subjects who experienced a complete resolution (defined as 100% resolution of at least one target tophus and no single tophus showing progression) of ≥1 target tophus was higher in the group treated with Zurampic 200 mg in combination with febuxostat compared with placebo in combination with febuxostat, although the difference was not statistically different (26% compared with 21%).
Danish: I CRYSTAL var andelen af forsøgspersoner, som oplevede fuldstændig resolution (defineret som 100 % resolution af mindst et target-tophus, og at intet tophus viste progression) på ≥1 target-tophus, højere i gruppen, som blev behandlet med Zurampic 200 mg i kombination med febuxostat, sammenlignet med placebo i kombination med febuxostat, selvom forskellen ikke var statistisk signifikant (26 % sammenlignet med 21 %).