FrancophonIA/ELRC3.0 huggingface dataset:
English: It is used if signs of bone disease are seen on X-rays.
Croatian: Primjenjuje se ako se na rendgenskim snimkama uoče bolesti kostiju.
English: Crysvita is a monoclonal antibody (a type of protein) designed to recognise and attach to the FGF23 protein.
Croatian: Crysvita je monoklonsko protutijelo (vrsta proteina) čija je svrha prepoznavanje i vezanje proteina FGF23.
English: Why is Crysvita approved?
Croatian: Zašto je lijek Crysvita odobren?
English: Because the number of patients with X-linked hypophosphataemia is low, the disease is considered ‘rare', and Crysvita was designated an ‘orphan medicine' (a medicine used in rare diseases) on 15 October 2014.
Croatian: Budući da je broj bolesnika s X-vezanom hipofosfatemijom nizak, dotična se bolest smatra „rijetkom” te je lijek Crysvita dobio status „lijeka za liječenje rijetkih bolesti” 15. listopada 2014.
English: Other information about Crysvita
Croatian: Ostale informacije o lijeku Crysvita
English: Crysvita is given as an injection under the skin.
Croatian: Crysvita se daje kao potkožna injekcija.
English: Crysvita contains the active substance burosumab.
Croatian: Crysvita sadrži djelatnu tvar burosumab.
English: For more information about treatment with Crysvita, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Croatian: Više informacija o liječenju lijekom Crysvita pročitajte u uputi o lijeku (također dio EPAR-a), odnosno obratite se svom liječniku ili ljekarniku.
English: Its side effects seem manageable.
Croatian: Čini se da se nuspojavama lijeka može upravljati.
English: Since Crysvita has been granted a conditional approval, the company that markets Crysvita will provide updated results from two ongoing studies in children aged between 5 and 12 years and between 1 and 4 years.
Croatian: Budući da je za lijek Crysvita dano uvjetno odobrenje, tvrtka koja stavlja na tržište lijek Crysvita podnosit će ažurirane rezultate dvaju tekućih ispitivanja u djece između 5 i 12 godina te između 1 i 4 godine.
English: Crysvita can be used in children over 1 year of age and adolescents with growing skeletons.
Croatian: Crysvita se može primjenjivati u djece u dobi od 1 i više godina te adolescenata koji još rastu.
English: Phosphate levels are largely controlled by the kidneys, which either remove excess phosphate or reabsorb it into the bloodstream when needed.
Croatian: Razine fosfata uvelike kontroliraju bubrezi, koji uklanjaju višak fosfata ili ga ponovno apsorbiraju u krvotok, kada je to potrebno.
English: Also, Crysvita must not be used in patients with high phosphate levels in the blood or in patients with severe kidney disease.
Croatian: Nadalje, lijek Crysvita ne smije se primjenjivati u bolesnika s visokim razinama fosfata u krvi ili u bolesnika s teškom bolesti bubrega.
English: For practical information about using Crysvita, patients should read the package leaflet or contact their doctor or pharmacist.
Croatian: Praktične informacije o primjeni lijeka Crysvita bolesnici trebaju pročitati u uputi o lijeku, odnosno obratiti se svom liječniku ili ljekarniku.
English: What information is still awaited for Crysvita?
Croatian: Koje se još informacije očekuju o lijeku Crysvita?
English: Crysvita is a medicine used for the treatment of X-linked hypophosphataemia, a hereditary disorder characterised by low levels of phosphate in the blood (hypophosphataemia).
Croatian: Crysvita je lijek koji se primjenjuje za liječenje X-vezane hipofosfatemije, nasljednog poremećaja obilježenog niskim razinama fosfata u krvi (hipofosfatemija).
English: By attaching to the FGF23 protein, the medicine blocks its activity, allowing the kidneys to reabsorb phosphate and restore normal levels of phosphate in the blood.
Croatian: Vezivanjem proteina FGF23 lijek blokira njegovo djelovanje, čime se bubrezima omogućava da ponovno apsorbiraju fosfate i da se ponovno uspostave normalne razine fosfata u krvi.
English: Patients with X-linked hypophosphataemia have abnormally high levels of a protein called FGF23 which causes the kidneys to stop reabsorbing phosphate into the bloodstream.
Croatian: Bolesnici s X-vezanom hipofosfatemijom imaju abnormalno visoke razine proteina FGF23, koji uzrokuje da bubrezi prestanu ponovno apsorbirati fosfate u krvotok.
English: The dose is adjusted according to the patient's phosphate levels in the blood.
Croatian: Doza se prilagođava sukladno razinama fosfata u krvi u bolesnika.
English: How is Crysvita used?
Croatian: Kako se Crysvita koristi?
English: How does Crysvita work?
Croatian: Kako djeluje Crysvita?
English: Crysvita was shown to reduce the severity of bone deformities in the wrist and knee and improve the level of phosphate in the blood of children with X-linked hypophosphataemia in one ongoing study, and further data are awaited.
Croatian: U jednom tekućem ispitivanju dokazano je da lijek Crysvita smanjuje težinu deformacije kostiju u zapešću i koljenu i povećava razinu fosfata u krvi u djece s X-vezanom hipofosfatemijom i očekuju se daljnji podaci.
English: Oral phosphate and vitamin D medicines must not be used during treatment with Crysvita.
Croatian: Tijekom liječenja lijekom Crysvita ne smiju se primjenjivati peroralni fosfat i analozi vitamina D.
English: Crysvita reduced the severity of rickets as shown in X-rays in children with X-linked hypophosphataemia.
Croatian: Lijek Crysvita ublažio je rahitis, kako je vidljivo u rendgenskim snimkama djece s X-vezanom hipofosfatemijom.
English: What benefits of Crysvita have been shown in studies?
Croatian: Koje su koristi lijeka Crysvita utvrđene u ispitivanjima?
English: For the full list of restrictions with Crysvita see the package leaflet.
Croatian: Potpuni popis ograničenja za lijek Crysvita potražite u uputi o lijeku.
English: The MAHs should identify a specific patient population for which the benefits of the product outweigh the risk.
Croatian: Nositelji odobrenja trebaju identificirati specifičnu populaciju pacijenata za koje dobrobiti nadmašuju rizik.
English: National Competent Authorities of Member State(s) or Reference Member State(s) if applicable, shall ensure that the following conditions are fulfilled by the MAH(s):
Croatian: Nadležna državna tijela države članice (država članica) koje koordiniraju referentne države članice (država članica) ukoliko je to primjenjivo pobrinut će se da nositelj(i) odobrenja ispune sljedeće uvjete:
English: Annex IV Conditions for lifting the suspension of the marketing authorisation
Croatian: Prilog IV Uvjeti za ukidanje suspenzije odobrenja za stavljanje lijeka u promet.
English: Initiation pack: 28 tablets (7 x 90 mg + 21 x 180 mg)
Croatian: Blister (Aclar/alu) Početno pakiranje: 28 tablete (7 x 90 mg +
English: 90 mg + 180 mg Film-coated tablet
Croatian: 90 mg + 180 mg
English: Your doctor will assess you carefully.
Croatian: Liječnik će Vas pažljivo procijeniti.
English: This pack is intended to be used for the first 10 days of treatment.
Croatian: Ovo pakiranje namijenjeno je za prvih 10 dana liječenja.
English: After 4 weeks:
Croatian: Nakon 4 tjedna:
English: Squeeze and hold at tabs above and below () Pull out card to the right ( )
Croatian: Stisnite i držite za jezičke iznad i ispod () Povucite karticu u desnu stranu ( )
English: DAYS 1-7 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7
Croatian: DAN 1. dan 2. dan 3. dan 4. dan 5. dan 6. dan 7. dan
English: Only safety data were collected in this study; no new safety signals were identified.
Croatian: U ovom ispitivanju prikupljeni su samo podaci o sigurnosti; nisu opažena nova upozorenja u odnosu na sigurnost.
English: Start of treatment (first 4 weeks):
Croatian: Početak liječenja (prva 4 tjedna)
English: This leaflet was last revised in {MM/YYYY}
Croatian: Ova uputa je zadnji put revidirana u {MM/GGGG}
English: Your doctor will discuss with you the risks and benefits of using this medicine in these situations.
Croatian: Liječnik će s Vama porazgovarati o rizicima i koristima od uzimanja ovog lijeka u tim situacijama.
English: The capsules can be taken either with or without food.
Croatian: Kapsule se mogu uzimati s hranom ili bez nje.
English: Like all medicines, this medicine can cause side effects, although not everybody gets them.
Croatian: Kao i svi drugi lijekovi, ovaj lijek može prouzročiti nuspojave, iako ih ne dobije svatko.
English: Do not stop taking this medicine without speaking to your doctor first, even if you begin to feel better.
Croatian: Nemojte prestati uzimati ovaj lijek a da prije niste razgovarali sa svojim liječnikom, čak i ako ste se počeli bolje osjećati.
English: Subjects were 25 to 80 years of age with a mean age of approximately 51 years.
Croatian: Ispitanici su bili u dobi od 25 do 80 godina, prosječne dobi od približno 51 godinu.
English: NUEDEXTA with food, drink and alcohol
Croatian: NUEDEXTA s hranom, pićem i alkoholom
English: Depending on your response to the treatment, your doctor may either decide:
Croatian: Ovisno o Vašem odgovoru na liječenje, liječnik može odlučiti:
English: Children and adolescents NUEDEXTA should not be used in children and adolescents below the age of 18 years.
Croatian: Djeca i adolescenti Lijek NUEDEXTA ne smiju uzimati djeca i adolescenti mlađi od 18 godina.
English: This medicine may cause changes in heart rhythm.
Croatian: Ovaj lijek može uzrokovati promjene u srčanom ritmu.
English: However, some side effects may be serious and require treatment.
Croatian: Međutim, neke nuspojave mogu biti ozbiljne i zahtijevaju liječenje.
English: NUEDEXTA is a combination of two active substances:
Croatian: NUEDEXTA je kombinacija dviju djelatnih tvari:
English: BEGINNING DAY 8 Day 8
Croatian: OD 8. DANA 8. dan
English: • you or a family member currently have or have ever had any heart disease or problems.
Croatian: • ako Vi ili neki član Vaše obitelji trenutačno imate ili ste prije imali neku srčanu bolest ili tegobe sa srcem.
English: Please ask your doctor if you are not sure, if any of the above applies to you.
Croatian: Molimo pitajte liječnika ako niste sigurno odnosi li se nešto od gore navedenog na Vas.
English: • sexual dysfunction
Croatian: • spolna disfunkcija
English: • Pivotal study (07-AVR-123)
Croatian: • Glavno ispitivanje (07-AVR-123)
English: If you have taken more capsules than you should, speak to your doctor immediately.
Croatian: Ako ste uzeli više kapsula nego što ste trebali, odmah se obratite svom liječniku.
English: Package leaflet: information for the user
Croatian: Uputa o lijeku: informacija za korisnika
English: (syncope), fall
Croatian: (sinkopa), pad
English: NMDA receptor antagonists (memantine)
Croatian: Antagonisti NMDA receptora (memantin)
English: Each blister is packed in a sleeve.
Croatian: Svaki blister pakiran je u omot.
English: Other antiarrhythmics with Class I (procainamide) or Class III activities should (if possible) be avoided.
Croatian: Druge antiaritmike aktivnosti klase I (prokainamid) ili klase III treba izbjegavati (ako je moguće).
English: No pharmacodynamic interactions were apparent.
Croatian: Nisu bile vidljive farmakodinamičke interakcije.
English: If this happens to you, do not drive or use machines.
Croatian: Vama nemojte voziti ni upravljati strojevima.
English: Stopping treatment may cause your symptoms to return.
Croatian: Prekid liječenja može prouzročiti da Vam se simptomi vrate.
English: Dose increase, if warranted, should be undertaken with caution in these patients.
Croatian: Povećanje doze, ako je potrebno, treba u tih bolesnika provoditi s oprezom.
English: Description:
Croatian: Opis:
English: The capsules should be taken orally at about the same time each day.
Croatian: Kapsule treba uzeti peroralno, otprilike u isto vrijeme svakoga dana.
English: It is very important to tell your doctor if you are taking any of the medicines listed below, as these medicines should never be taken while you are taking NUEDEXTA:
Croatian: Izuzetno je važno da liječniku kažete ako uzimate neki od niže navedenih lijekova, jer se ti lijekovi nikada ne smiju uzimati kada se uzima NUEDEXTA:
English: Non-clinical data reveal no special hazard for a genotoxicity or carcinogenic potential, nor for fertility impairment.
Croatian: Neklinički podaci ne ukazuju na poseban rizik u odnosu na genotoksičnost ili kancerogeni potencijal, niti na oštećenje plodnosti.
English: Prior to launch in each Member State the Marketing Authorisation Holder (MAH) shall agree an educational programme with the National Competent Authority.
Croatian: Prije stavljanja lijeka na tržište u svakoj zemlji članici, nositelj odobrenja (MAH) dogovorit će s nadležnim državnim tijelom edukacijski program.
English: If you forget to take 1 or more capsules, you must not take a double dose to make up for the missed doses.
Croatian: Ako ste zaboravili uzeti 1 ili više kapsula, nemojte uzeti dvostruku dozu kako biste nadoknadili propuštenu dozu.
English: These may be a sign of a serious condition called “serotonin syndrome”.
Croatian: To može biti znak ozbiljnog stanja zvanog „serotoninski sindrom“.
English: • loss of appetite (anorexia)
Croatian: • gubitak apetita (anoreksija)
English: The dose of paroxetine can then be adjusted based on clinical response; however, dosage above 35 mg/day is not recommended.
Croatian: Dozu paroksetina tada se može prilagoditi na temelju kliničkog odgovora; međutim, ne preporučuje se doza veća od 35 mg na dan.
English: The capsule should be taken orally (by mouth) either with or without food at about the same time each day.
Croatian: Kapsula se uzima oralno (kroz usta) s hranom ili bez nje, otprilike u isto vrijeme svakoga dana.
English: Furthermore, educational material for HCPs should provide information on the following safety concerns and on the actions needed to reduce the risks:
Croatian: Nadalje, edukacijski materijal za zdravstvene djelatnike treba pružiti informacije za sljedeće sigurnosne mjere i djelovanja, potrebne kako bi se smanjio rizik u odnosu na:
English: Adverse reactions observed with this medicine may occur more often or may worsen and your doctor may perform some test and monitor you more closely.
Croatian: Štetne reakcije opažene uz ovaj lijek mogu se događati češće ili se mogu pogoršavati, pa će Vam liječnik možda provoditi neku pretragu i pažljivije Vas pratiti.
English: In case a dose is missed, patients should not take an additional dose, but take the prescribed next dose at the usual time.
Croatian: U slučaju propuštene doze, bolesnik ne smije uzeti dodatnu dozu, nego treba nastaviti sa sljedećom propisanom dozom u uobičajeno vrijeme.
English: Stop taking NUEDEXTA and seek medical attention immediately if any of the above symptoms occur.
Croatian: Prekinite s uzimanjem lijeka NUEDEXTA i odmah potražite medicinsku pozornost ako Vam se pojavi neki od gornjih simptoma.
English: • For the first seven days of treatment: one capsule per day, taken in the morning.
Croatian: • prvih sedam dana liječenja: jedna kapsula na dan, uzeta ujutro.
English: Other hypersensitivity reactions
Croatian: Druge reakcije preosjetljivosti
English: • Weeks 2-4 (day 8-28):
Croatian: • od 2. do 4. tjedna (od 8. do 28. dana):
English: Your doctor will decide if you should take this medicine while breast-feeding.
Croatian: Liječnik će odlučiti trebate li uzimati ovaj lijek dok dojite.
English: Talk to your doctor before and after taking NUEDEXTA if:
Croatian: Obratite se liječniku prije i nakon uzimanja lijeka NUEDEXTA:
English: Treatment of hypotension and of other signs and symptoms should be directed at symptomatic and supportive measures.
Croatian: Liječenje hipotenzije i drugih znakova i simptoma treba biti usmjereno na simptomatske i potporne mjere.
English: Take your next dose at the usual time and make sure that approximately 12 hours passes between two doses.
Croatian: Svoju sljedeću dozu uzmite u uobičajeno vrijeme i vodite računa da je između dviju doza prošlo približno 12 sati.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, or if you are not using reliable contraception, ask your doctor for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate trudnoću ili ne rabite pouzdanu kontracepciju, obratite se liječniku za savjet prije nego što uzmete ovaj lijek.
English: Pharmacotherapeutic group: Other nervous system drugs; ATC code: N07XX59
Croatian: Farmakoterapijska skupina: Drugi lijekovi s djelovanjem na živčani sustav; ATK oznaka: N07XX59
English: Day 9
Croatian: 9. dan
English: What NUEDEXTA is and what it is used for
Croatian: Što je NUEDEXTA i za što se koristi
English: If you have certain heart problems or are currently taking certain other medicines, NUEDEXTA may not be appropriate for you, or your doctor may want to monitor your heart activity when you start NUEDEXTA.
Croatian: Ako imate određenih srčanih tegoba ili sada uzimate neke druge lijekove, NUEDEXTA možda za Vas nije prikladan lijek, a možda će Vam liječnik htjeti nadzirati rad srca kada počnete uzimati lijek NUEDEXTA.
English: Paroxetine exposure (AUC0-24) increased by 1.7 fold and Cmax increased by 1.5 fold.
Croatian: Izloženost paroksetinu (AUC0-24) povećala se 1,7 puta, a Cmax 1,5 puta.
English: • Studies to Assess Cardiac Effects
Croatian: • Ispitivanja za procjenu učinaka na srčanu aktivnost
English: Each bottle will be contained within a carton.
Croatian: Svaka bočica nalazi se u kutiji.
English: In addition it shows affinity for the serotonin transporter (SERT) and for the 5-HT1B/D receptor.
Croatian: Osim toga, pokazuje afinitet za serotoninski prijenosnik (SERT) te za receptor 5-HT1B/D.
English: Hepatitis, including granulomatous hepatitis, has been reported in patients receiving quinidine, generally during the first few weeks of therapy.
Croatian: Hepatitis, uključujući granulomatozni hepatitis, prijavljen je u bolesnika koji su primali kinidin, obično u prvih nekoliko tjedana terapije.
English: The most important effects of acute overdoses are ventricular arrhythmias and hypotension.
Croatian: Najvažniji učinci akutnog predoziranja jesu ventrikularne aritmije i hipotenzija.
English: In addition, the maintenance of the clinical effect of NUEDEXTA in the patient should be regularly monitored in the long-term against its tolerability, in order to ascertain the continued benefit of the product.
Croatian: Osim toga, održavanje kliničkog učinka lijeka NUEDEXTA u bolesnika treba redovito nadzirati na dugi rok u odnosu na podnošljivost, kako bi se potvrdila stalna korist lijeka.
English: • atomoxetine, used to treat attention-deficit hyperactivity disorder (ADHD)
Croatian: • atomoksetin za liječenje poremećaja pomanjkanja pažnje s hiperaktivnošću (ADHD)
English: • Week 1 (day 1-7):
Croatian: • 1. tjedan (od 1. do 7. dana):
English: If you take more NUEDEXTA than you should
Croatian: Ako uzmete više lijeka NUEDEXTA nego što ste trebali
English: Other medicines and NUEDEXTA
Croatian: Drugi lijekovi i NUEDEXTA
English: • tamoxifen, used to treat or prevent some cancers
Croatian: • tamoksifen, koristi se za liječenje i sprječavanje nekih vrsta raka
English: ritonavir, saquinavir, amprenavir, fosamprenavir
Croatian: ritonavir, sakvinavir, amprenavir, fosamprenavir
English: There are several hydroxylated metabolites of quinidine.
Croatian: Postoji nekoliko hidroksiliranih metabolita kinidina.
English: Quinidine
Croatian: Kinidin
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from NUEDEXTA therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je odlučiti prekinuti li dojenje ili prekinuti liječenje/suzdržati se od liječenja NUEDEXTOM uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: If any of the above occur, stop taking the capsules and tell your doctor immediately
Croatian: Ako se nešto od gore navedenog pojavi Vama, prekinite s uzimanjem kapsula i odmah obavijestite liječnika.
English: Quinidine clearance is unaffected, although there is an increased volume of distribution that leads to an increase in the elimination half-life.
Croatian: Klirens kinidina nije zahvaćen, iako postoji povećan volumen distribucije koji dovodi do povećanog poluvremena eliminacije.
English: Anticholinergic effects of quinidine
Croatian: Antikolinergički učinci kinidina
English: Your doctor will closely monitor you for side effects and/or may need to adjust the dose of the other medicine or NUEDEXTA.
Croatian: Liječnik će kod Vas pažljivo nadzirati moguću pojavu nuspojava i/ili će možda trebati prilagoditi dozu drugog lijeka ili lijeka NUEDEXTA.
English: • medicines to reduce pain and/or cough, such as codeine and hydrocodone
Croatian: • lijekovi za ublažavanje bolova i/ili kašlja kao što su kodein i hidrokodon
English: • increased liver enzymes (GGT, AST, ALT)
Croatian: • povišeni jetreni enzimi (GGT, AST, ALT)
English: • double vision, blurred vision
Croatian: • dvostruke slike, zamućen vid
English: • excessive muscle stiffness (spasticity)
Croatian: • prekomjerno ukočenost mišića (spastičnost)
English: Studies in animals (rats and rabbits) have shown developmental toxicity, including teratogenicity and embryolethality (see section 5.3).
Croatian: Ispitivanja na životinjama (štakori i kunići) pokazala su razvojnu toksičnost, uključujući teratogenost i smrtnost embrija (vidjeti dio 5.3).
English: ECG should be re-evaluated if risk factors for QTc prolongation change significantly during treatment with NUEDEXTA.
Croatian: EKG procjenu treba ponoviti, ako se čimbenici rizika za produljenje QTc intervala značajno promijene tijekom terapije NUEDEXTOM.
English: • if you are allergic to dextromethorphan, quinidine or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični na dekstrometorfan, kinidin ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: NUEDEXTA should be discontinued if hepatitis occurs unless it is clearly not treatment related.
Croatian: NUEDEXTA se treba obustaviti ako se pojavi hepatitis, osim kad je jasno da nije povezan s liječenjem.
English: The clinical relevance of this observation to drugs that are OCT1 substrates, such as metformin, is unknown.
Croatian: Nije poznata klinička važnost ovog opažanja za lijekove koji su supstrati OCT1, primjerice metformin.
English: • travel or motion sickness, ringing in the ears (tinnitus)
Croatian: • bolest kretanja ili putovanja, zvonjava u ušima (tinitus)
English: What NUEDEXTA is and what it is used for What you need to know before you take NUEDEXTA How to take NUEDEXTA
Croatian: Što je NUEDEXTA i za što se koristi Što morate znati prije nego počnete uzimati lijek NUEDEXTA
English: • you have problems with your liver or kidney.
Croatian: • imate tegoba s jetrom ili bubrezima.
English: When NUEDEXTA is used with other serotoninergic medicines, the risk of “serotonin syndrome” may be increased due to pharmacodynamic interaction.
Croatian: Kada se NUEDEXTA uzima s drugim serotoninergičkim lijekovima, rizik od „serotoninskog sindroma“ može se povećati zbog farmakodinamičkih interakcija.
English: • The active substances are:
Croatian: • Djelatne tvari su:
English: How to store NUEDEXTA Contents of the pack and other information
Croatian: Kako čuvati lijek NUEDEXTA Sadržaj pakiranja i druge informacije
English: Caution is required when administering NUEDEXTA in combination with flecainide, chlorpromazine and haloperidol.
Croatian: Oprez je potreban kada se NUEDEXTA primjenjuje u kombinaciji s flekainidom, klorpromazinom i haloperidolom.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim poremećajima nepodnošenja galaktoze, nedostatka Lapp laktaze ili malapsorpcije glukoze-galaktoze ne smiju uzimati ovaj lijek.
English: When the urine pH is less than 7, about 20% of administered quinidine appears unchanged in the urine, but this fraction drops to as little as 5% when the urine is more alkaline.
Croatian: Kada je pH mokraće manji od 7, oko 20% primijenjenog kinidina pojavi se nepromijenjeno u mokraći, ali ta frakcija padne na samo 5% ako je mokraća lužnatija.