FrancophonIA/ELRC3.0 huggingface dataset:
English: These could be symptoms of a condition called “Capillary Leak Syndrome” which causes blood to leak from the small blood vessels into your body and needs urgent medical attention.
Slovenian: To so lahko simptomi bolezenskega stanja, imenovanega ''sindrom kapilarne prepustnosti'', ki povzroči puščanje krvi iz drobnih žilic v telesu in zahteva nujno zdravniško pomoč.
English: Diluted filgrastim may be adsorbed to glass and plastic materials except diluted, as mentioned below.
Slovenian: Razredčen filgrastim se lahko adsorbira na steklo in plastične materiale, razen če je razredčen, kot je opisano v nadaljevanju.
English: Particular attention should be paid to the number of progenitors mobilised in such patients before the administration of high-dose chemotherapy.
Slovenian: Posebno pozornost je treba posvetiti številu matičnih celic, ki jih je možno mobilizirati pri teh bolnikih preden prejmejo kemoterapijo v velikih odmerkih.
English: However, the administration of melphalan, carboplatin or BCNU together with filgrastim has been shown to be effective for progenitor mobilisation.
Slovenian: Vendar je bilo ugotovljeno, da je uporaba melfalana, karboplatina ali BCNU skupaj s filgrastimom učinkovita pri mobilizaciji krvnih matičnih celic.
English: Thereafter, it is recommended that the ANC is measured at least twice per week for the first two weeks and subsequently once per week or once every other week during maintenance therapy.
Slovenian: Priporočljivo je, da se v prvih 2 do 3 dneh zdravljenja s filgrastmom vsak dan meri vrednost ANC, pozneje pa je priporočljivo, da se ANC meri najmanj dvakrat na teden v prvih dveh tednih, potem pa enkrat na teden ali enkrat vsak drugi teden v času vzdrževalnega zdravljenja.
English: 9/L) was observed in 41% of normal donors and transient thrombocytopenia (platelets < 100 x 10
Slovenian: 9/l) so opazili pri 41 % zdravih darovalcev, prehodno trombocitopenijo (število trombocitov < 100 x 10
English: • worsening of rheumatoid arthritis
Slovenian: • poslabšanje revmatoidnega artritisa
English: When you have completed the injection, slide the needle guard forward until the needle is completely covered (device ‘clicks' into place).
Slovenian: Ko boste zaključili z injiciranjem, potegnite varnostno zaščito igle naprej, da bo igla popolnoma pokrita (zaščita se zaskoči s klikom).
English: cells/kg recipient body weight in the majority of the donors after two leukapheresis.
Slovenian: na kg prejemnikove telesne mase pri večini darovalcev že po dveh levkaferezah.
English: When reversal of neutropenia has been achieved, the minimal effective dose to maintain a normal neutrophil count should be established.
Slovenian: Ko je nevtropenija odpravljena, je treba določiti minimalni še učinkoviti odmerek za ohranjanje normalnega števila nevtrofilcev.
English: Congenital, idiopathic or cyclic neutropenia: Filgrastim should be given by subcutaneous injection.
Slovenian: Prirojena, idiopatska ali ciklična nevtropenija: filgrastim je treba dajati v obliki subkutane injekcije.
English: Special warning and precautions across indications
Slovenian: Posebna opozorila in previdnostni ukrepi pri vseh indikacijah
English: • fever (pyrexia)
Slovenian: • vročina (pireksija)
English: Absolute neutrophil count (ANC) should be monitored closely, especially during the first few weeks of filgrastim therapy.
Slovenian: Skrbno je treba spremljati absolutno število nevtrofilcev (ANC), še posebej v prvih nekaj tednih zdravljenja s filgrastimom.
English: The serum elimination half-life of filgrastim is approximately 3.5 hours, with a clearance rate of approximately 0.6 ml/min/kg.
Slovenian: Razpolovni čas izločanja filgrastima iz seruma znaša približno 3,5 ure z očistkom približno 0,6 ml/min/kg.
English: Pack sizes of 1, 5, 8 or 10 pre-filled syringes.
Slovenian: Velikosti pakiranj po 1, 5, 8 ali 10 napolnjenih brizg.
English: Slowly push down the plunger until all the contents of the syringe have been emptied.
Slovenian: Počasi potiskajte bat, dokler ne boste izpraznili vse vsebine brizge.
English: 9/L) following filgrastim administration and leukapheresis was observed in 35% of subjects studied.
Slovenian: 9/l) po dajanju filgrastima in levkaferezi so ugotovili pri 35 % preučevanih oseb.
English: In patients with severe chronic neutropenia (SCN)
Slovenian: Pri bolnikih s hudo kronično nevtropenijo (SCN - »severe chronic neutropenia«)
English: Sweets syndrome
Slovenian: Sweetov sindrom
English: In some SCN patients filgrastim can also induce a minor increase in the number of circulating eosinophils and basophils relative to baseline; some of these patients may present with eosinophilia or basophilia already prior to treatment.
Slovenian: Pri nekaterih bolnikih s SCN lahko filgrastim sproži tudi manjše povečanje števila eozinofilcev in bazofilcev v krvi v primerjavi z začetnimi vrednostmi, nekateri od teh bolnikov pa imajo lahko že pred zdravljenjem eozinofilijo ali bazofilijo.
English: Regular blood tests will be taken to monitor the number of white blood cells in your body.
Slovenian: Za spremljanje števila belih krvničk bodo potrebne redne krvne preiskave.
English: Filgrastim should be given by subcutaneous injection.
Slovenian: Filgrastim je treba dajati v obliki subkutane injekcije.
English: Do not take a double dose to make up for any missed doses.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 x 10
Slovenian: Pri bolnikih - otrocih ali odraslih s hudo prirojeno, ciklično ali idiopatsko nevtropenijo z absolutnim številom nevtrofilcev (»absolute neutrophil count« - ANC)  0,5 x 10
English: You will need to take Nivestim until your white blood cell count is normal.
Slovenian: Zdravilo Nivestim boste morali jemati, dokler ne bo število belih krvničk v vaši krvi normalno.
English: When handling the pre-filled syringe, keep hands behind the needle.
Slovenian: Pri ravnanju z napolnjeno injekcijsko brizgo držite roke za iglo.
English: • A sharps container (puncture proof container) for disposing of used syringes safely.
Slovenian: • vsebnik za odlaganje ostrih odpadkov (vsebnike, ki so odporni proti prebadanju) za varno odlaganje uporabljenih brizg.
English: After injecting the solution remove the needle from the skin.
Slovenian: Po injiciranju raztopine iztaknite iglo iz kože.
English: Special precautions in cancer patients
Slovenian: Posebni previdnostni ukrepi pri bolnikih z rakom
English: • notice unusual bleeding or bruising (these may be symptoms of a decrease in blood platelets (thrombocytopenia), with a reduced ability of your blood to clot).
Slovenian: • opazite neobičajno krvavitev ali modrice (to so lahko simptomi zmanjšanja števila trombocitov (trombocitopenija) z zmanjšano sposobnostjo strjevanja krvi).
English: This reduces the ability of your blood to clot (thrombocytopenia).
Slovenian: To zmanjša sposobnost strjevanja vaše krvi (trombocitopenija).
English: The effects of filgrastim in patients with substantially reduced myeloid progenitors have not been studied.
Slovenian: Učinki filgrastima pri bolnikih z znatno zmanjšanim številom mieloičnih matičnih celic še niso bili preučeni.
English: A diagnosis of splenic rupture should be considered in donors and/or patients reporting left upper abdominal or shoulder tip pain.
Slovenian: Na diagnozo rupture vranice je treba pomisliti pri darovalcih in/ali pri bolnikih, ki tožijo o bolečinah v zgornjem levem delu trebuha ali o bolečinah na vrhu rame.
English: Nivestim containing r-metHuG-CSF (filgrastim) causes marked increases in peripheral blood neutrophil counts within twenty four hours, with minor increases in monocytes.
Slovenian: Zdravilo Nivestim vsebuje r-metHuG-CSF (filgrastim), ki povzroča izrazito povečanje števila nevtrofilcev v periferni krvi v roku 24 ur, z manjšim povečanjem števila monocitov.
English: Use of filgrastim in patients with HIV infection maintains normal neutrophil counts to allow scheduled dosing of antiviral and/or other myelosuppressive medication.
Slovenian: Z uporabo filgrastima pri bolnikih, okuženih z virusom HIV, je možno ohranjanje normalnega števila nevtrofilcev kar omogoči načrtovano odmerjanje protivirusnega in/ali drugega mielosupresivnega zdravila.
English: The mechanism of vasculitis in patients receiving filgrastim is unknown.
Slovenian: Mehanizem nastanka vaskulitisa pri bolnikih, ki so prejemali filgrastim, ni znan.
English: A subset of approximately 12% of patients who had normal cytogenetic evaluations at baseline were subsequently found to have abnormalities, including monosomy 7, on routine repeat evaluation.
Slovenian: Pri podskupini približno 12 % bolnikov, ki so imeli na začetku normalen citogenetski izvid, so pri poznejšem ponovnem rutinskem pregledu ugotovili nepravilnosti, vključno z monosomijo 7.
English: In pregnant rats, no maternal or foetal toxicity was observed at doses up to 575 µg/kg/day.
Slovenian: Pri brejih podganah pri odmerkih do 575 µg/kg/dan niso opazili toksičnosti za mater ali plod.
English: Cases of capillary leak syndrome have been reported with granulocyte colony-stimulating factor use.
Slovenian: Poročali so o primerih sindroma kapilarne prepustnosti med uporabo granulocitne kolonije stimulirajočega faktorja.
English: In order to determine a patient's trough or nadir ANC, it is recommended that blood samples are taken for ANC measurement immediately prior to any scheduled dosing with filgrastim.
Slovenian: Da bi ugotovili bolnikovo najnižjo vrednost ANC, je priporočljivo odvzeti krvne vzorce za merjenje ANC tik pred načrtovanim odmerkom filgrastima.
English: The onset of pulmonary signs, such as cough, fever and dyspnoea in association with radiological signs of pulmonary infiltrates and deterioration in pulmonary function may be preliminary signs of acute respiratory distress syndrome (ARDS).
Slovenian: Pojav pljučnih znakov, kot so kašelj, zvišana telesna temperatura in dispneja v povezavi z radiološkimi znaki pljučnih infiltratov in poslabšanjem pljučne funkcije, so lahko preliminarni znaki sindroma akutne dihalne stiske (ARDS - Acute Pulmonary Distress Syndrome).
English: If required, Nivestim may be diluted in 5% glucose solution.
Slovenian: Če je potrebno, lahko zdravilo Nivestim razredčite s 5-odstotno raztopino glukoze.
English: • sudden life-threatening allergic reaction (anaphylactic reaction)
Slovenian: • nenadna življenjsko ogrožajoča alergijska reakcija (anafilaktična reakcija)
English: Osteoporosis
Slovenian: Osteoporoza
English: • experience puffiness in your face or ankles, blood in your urine or brown-coloured urine or you notice you urinate less than usual (glomerulonephritis).
Slovenian: • opazite zabuhlost obraza ali gležnjev, kri v urinu ali rjavo obarvan urin, ali če opazite, da urinirate manj kot običajno (glomerulonefritis).
English: The effects of filgrastim overdosage have not been established.
Slovenian: Učinkov prevelikega odmerjanja filgrastima še niso ugotovili.
English: For patients treated with filgrastim diluted to concentrations below 1.5 MU (15 µg) per ml, human serum albumin (HSA) should be added to a final concentration of 2 mg/ml.
Slovenian: Za bolnike, ki se zdravijo s filgrastimom, razredčenim do koncentracije manjše od 1,5 M e. (15 µg) na ml, je treba dodati še humani serumski albumin (HSA) do končne koncentracije 2 mg/ml.
English: Statistical analysis of the relationship between the number of CD34
Slovenian: Statistična analiza razmerja med številom ponovno infundiranih celic CD34
English: 9/L were reported and attributed to the leukapheresis procedure.
Slovenian: 9/l, ki so ju pripisali izvedbi postopka levkafereze.
English: 9/L, and a history of severe or recurrent infections, long term administration of filgrastim is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.
Slovenian: 9/l in hudimi ali ponavljajočimi se okužbami v anamnezi je indicirana dolgotrajna uporaba filgrastima za povečanje števila nevtrofilcev in zmanjšanje pojavnosti in trajanja z okužbami povezanih dogodkov.
English: The stem cells will then go back into the bone marrow and produce blood cells; - to increase the number of white blood cells if you suffer from severe chronic neutropenia to help prevent infections; - in patients with advanced HIV infection which will help reduce the risk of infections.
Slovenian: Matične celice se vrnejo v kostni mozeg in tvorijo krvničke; - za povečevanje števila belih krvničk, če imate hudo kronično nevtropenijo, kot pomoč pri preprečevanju okužb; - pri bolnikih z napredovalo okužbo z virusom HIV, kar bo pripomoglo k zmanjšanju tveganje za okužbe.
English: Neutropenia may be due to bone marrow infiltrating opportunistic infections such as Mycobacterium avium complex or malignancies such as lymphoma.
Slovenian: Nevtropenija je lahko posledica infiltracije kostnega mozga z oportunističnimi okužbami, npr. kompleksom Mycobacterium avium ali malignim obolenjem, kot je limfom.
English: • decreased feeling of sensitivity, especially in the skin (hypoaesthesia)
Slovenian: • zmanjšan občutek občutljivosti, zlasti na dotik (hipestezija)
English: Because of the potential of receiving higher doses of chemotherapy (e.g. full doses on the prescribed schedule) the patient may be at greater risk of thrombocytopenia and anaemia.
Slovenian: Zaradi možnosti prejemanja večjih odmerkov kemoterapije (npr. polnih odmerkov po predpisani shemi), je lahko bolnik bolj ogrožen zaradi trombocitopenije in anemije.
English: Patients who have undergone very extensive prior myelosuppressive therapy may not show sufficient mobilisation of PBPC to achieve the recommended minimum yield (≥ 2.0 x 10
Slovenian: Pri bolnikih, ki so imeli zelo obsežno predhodno mielosupresivno zdravljenje, morda ne bo prišlo do zadostne mobilizacije krvotvornih matičnih celic v periferno kri, da bi dosegli najmanjši priporočeni delež celic (≥ 2,0 x 10
English: The Nivestim syringe plunger stopper and needle cover are not made with natural rubber latex.
Slovenian: Batni zamašek injekcijske brizge z zdravilom Nivestim in pokrovček igle nista izdelana iz gume iz naravnega lateksa.
English: This observation has only been made in patients with congenital neutropenia.
Slovenian: To so opazili samo pri bolnikih s prirojeno nevtropenijo.
English: Since lithium promotes the release of neutrophils, lithium is likely to potentiate the effect of filgrastim.
Slovenian: Ker litij pospešuje sproščanje nevtrofilcev, lahko okrepi učinek filgrastima.
English: Among these, two cases of platelets < 50 x 10
Slovenian: Med temi so pri dveh primerih poročali o številu trombocitov < 50 x 10
English: A meta-analysis of allogeneic transplant studies, including the results of nine prospective randomized trials, 8 retrospective studies and 1 case-controlled study, did not detect an effect on the risks of acute GvHD, chronic GvHD or early treatment-related mortality.
Slovenian: Metaanaliza študij alogenske presaditve, ki je vključevala rezultate devetih prospektivnih randomiziranih preskušanj, osmih retrospektivnih študij in ene študije primerov s kontrolami, ni pokazala vpliva na tveganje za akutni pojav reakcij presadka proti gostitelju, kronični pojav reakcij presadka proti gostitelju ali zgodnjo, z zdravljenjem povezano umrljivostjo.
English: It is important that you do not try to give yourself the injection unless you have received special training from your doctor or nurse.
Slovenian: Pomembno je, da si ne skušate zdravila injicirati sami, če vas zdravnik ali medicinska sestra nista o tem posebej poučila.
English: Studies of filgrastim in patients with severe impairment of renal or hepatic function demonstrate that it exhibits a similar pharmacokinetic and pharmacodynamic profile to that seen in normal individuals.
Slovenian: Študije uporabe filgrastima pri bolnikih s hudo okvaro delovanja ledvic ali jeter kažejo, da ima podoben farmakokinetični in farmakodinamični profil, kot so ga ugotavljali pri normalnih posameznikih.
English: The recommended starting dose of filgrastim is 0.1 MU (1 µg)/kg/day with titration up to a maximum of 0.4 MU (4 µg)/kg/day until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 10
Slovenian: Priporočeni začetni odmerek filgrastima je 0,1 M e. (1 µg)/kg/dan, s titracijo odmerka do največ 0,4 M e. (4 µg)/kg/dan, dokler ni doseženo normalno število nevtrofilcev in ga je mogoče ohranjati (vrednost ANC > 2,0 x 10
English: Malignant cell growth
Slovenian: Rast malignih celic
English: Excipient with known effect Each ml of solution contains 50 mg of sorbitol (E420) (see section 4.4).
Slovenian: Pomožna snov z znanim učinkom: 1 ml raztopine vsebuje 50 mg sorbitola (E420) (glejte poglavje 4.4).
English: Assessment of progenitor cell yields
Slovenian: Ocena deležev matičnih celic
English: Donors who receive G-CSFs for PBPC mobilisation should be monitored until haematological indices return to normal.
Slovenian: Darovalce, ki so prejeli G-CSF za mobilizacijo matičnih celic v periferno kri, je treba spremljati dokler se hematološke vrednosti ne povrnejo na normalo.
English: Acute myeloid leukaemia
Slovenian: Akutna mieloična levkemija
English: For patients who have not had extensive chemotherapy, one leukapheresis is often sufficient.
Slovenian: Za bolnike, ki niso imeli obsežne kemoterapije, pogosto zadostuje ena levkafereza, v drugačnih okoliščinah pa je priporočljiva dodatna levkafereza.
English: Platelet counts should be monitored closely, especially during the first few weeks of filgrastim therapy.
Slovenian: Število trombocitov je treba skrbno spremljati, še posebej v prvih nekaj tednih zdravljenja s filgrastimom.
English: Chronic GvHD
Slovenian: Kronična GvHD
English: • increase in white blood cells (leucocytosis)
Slovenian: • povečanje števila belih krvnih celic (levkocitoza)
English: During intermittent dosing with 30 MU (300 µg)/day of filgrastim, there can be wide fluctuations in the patient's ANC over time.
Slovenian: Med intermitentnim odmerjanjem filgrastima po 30 M e. (300 µg)/dan so včasih opazna velika nihanja pri bolnikovih vrednostih ANC skozi čas.
English: A common side effect of filgrastim use is pain in your muscles or bones (musculoskeletal pain), which can be helped by taking standard pain relief medicines (analgesics).
Slovenian: Pogost neželeni učinek uporabe filgrastima so bolečine v mišicah in kosteh (mišično-skeletne bolečine), ki jih je mogoče lajšati s standardnimi protibolečinskimi zdravili (analgetiki).
English: Filgrastim should be discontinued and appropriate treatment given.
Slovenian: V takšnih primerih je treba zdravljenje s filgrastimom prekiniti in uvesti ustrezno zdravljenje.
English: Based on reported data for another filgrastim product similar to the originator, comparable findings plus increased foetal malformations were observed at 100 µg/kg/day, a maternally toxic dose which corresponded to a systemic exposure of approximately 50-90 times the exposures observed in patients treated with the clinical dose of 5 µg/kg/day.
Slovenian: Na osnovi podatkov za drugo zdravilo, ki vsebuje filgrastim in je podobno originatorskemu zdravilu, so primerljive ugotovitve plus zvečano število malformacij ploda opazili pri 100 µg/kg/dan, pri odmerku, ki je bil toksičen za mater in ustreza približno 50-90-krat večji sistemski izpostavljenosti kot je izpostavljenost bolnikov, ki se zdravijo s kliničnimi odmerki 5 µg/kg/dan.
English: Particular care should be taken to distinguish the diagnosis of blast transformation of chronic myeloid leukaemia from acute myeloid leukaemia.
Slovenian: Posebno pozornost je treba nameniti razlikovanju diagnoze blastne transformacije pri kronični mieloični levkemiji od akutne mieloične levkemije.
English: Clearance of filgrastim has been shown to follow first-order pharmacokinetics after both subcutaneous and intravenous administration.
Slovenian: Izkazalo se je, da očistek filgrastima sledi farmakokinetiki prvega reda tako po subkutani kot po intravenski uporabi.
English: One retrospective European study evaluating the use of GCSF after allogeneic bone marrow transplantation in patients with acute leukaemias suggested an increase in the risk of GvHD, treatment related mortality (TRM) and mortality when GCSF was administered.
Slovenian: Ena retrospektivna evropska študija za vrednotenje uporabe G-CSF po alogenski presaditvi kostnega mozga pri bolnikih z akutno levkemijo je pokazala povečanje tveganja za pojav reakcij presadka proti gostitelju (GvHD), z zdravljenjem povezane umrljivosti (TRM - treatment related mortality) in umrljivosti pri uporabi G-CSF.
English: Leukapheresis should be performed during the period when the ANC rises from < 0.5 x 10
Slovenian: Levkaferezo je treba opravljati v času, ko se vrednost ANC poveča z < 0,5 x 9/l na > 5,0 x 10
English: The effects of filgrastim on neutropenia due to bone marrow infiltrating infection or malignancy have not been well established.
Slovenian: Učinki filgrastima na nevtropenijo, ki je posledica infiltracije kostnega mozga z okužbo ali malignim obolenjem, še niso dobro raziskani.
English: Special warning and precautions associated with co-morbidities
Slovenian: Posebno opozorilo in previdnostni ukrepi, povezani s sočasnimi boleznimi
English: Intravenous (80 µg/kg/day) administration of filgrastim to rabbits during the period of organogenesis was maternally toxic and increased spontaneous abortion, post-implantation loss, and decreased mean live litter size and foetal weight were observed.
Slovenian: Intravensko (80 µg/kg/dan) dajanje filgrastima kuncem v obdobju organogeneze je bilo toksično za mater, opazili so povečano število spontanih splavov, pogostejšo izgubo zarodka po implantaciji in zmanjšano velikost in maso ploda.
English: Use of filgrastim in patients, children or adults, with SCN (severe congenital, cyclic, and idiopathic neutropenia) induces a sustained increase in absolute neutrophil counts in peripheral blood and a reduction of infection and related events.
Slovenian: Uporaba filgrastima pri bolnikih (otrocih ali odraslih) s SCN (hudo prirojeno, ciklično in idiopatsko nevtropenijo) povzroči trajno povečanje absolutnega števila nevtrofilcev v periferni krvi in zmanjšanje okužb ter z njimi povezanih pojavov.
English: Hold the syringe with the needle pointing upwards.
Slovenian: Brizgo držite tako, da bo igla obrnjena navzgor.
English: Nivestim is not recommended during pregnancy.
Slovenian: Uporaba zdravila Nivestim ni priporočljiva med nosečnostjo.
English: • lack of absorption of oxygen in the lung (hypoxia)
Slovenian: • pomanjkanje absorpcije kisika v pljučih (hipoksija)
English: Filgrastim may be given as a 24 hour subcutaneous continuous infusion or subcutaneous injection.
Slovenian: Filgrastim lahko dajemo v obliki 24-urne kontinuirane subkutane infuzije ali subkutane injekcije.
English: • severe pain in the bones, chest, gut or joints (sickle cell anaemia with crisis)
Slovenian: • huda bolečina v kosteh, prsnem košu, trebuhu ali sklepih (srpastocelična anemija s krizo)
English: Nivestim contains sorbitol (E420).
Slovenian: Zdravilo Nivestim vsebuje sorbitol (E420).
English: Leukapheresis should not be performed in donors who are anticoagulated or who have known defects in haemostasis.
Slovenian: Levkafereze se ne sme izvajati pri darovalcih, ki se zdravijo z antikoagulanti ali imajo znano motnjo hemostaze.
English: Special care should be taken when administering single or combination chemotherapeutic agents which are known to cause severe thrombocytopenia.
Slovenian: Posebna previdnost je potrebna pri uporabi enega kemoterapevtika ali kombinacije kemoterapevtikov, za katere je znano, da povzročajo hudo trombocitopenijo.
English: • high uric acid levels in the blood, which may cause gout (hyperuricaemia) (Blood uric acid increased)
Slovenian: • povečane ravni sečne kisline v krvi, kar lahko povzroči putiko (hiperurikemija) (zvečanje vrednosti sečne kisline v krvi)
English: There is no evidence that patients with HIV infection treated with filgrastim show an increase in HIV replication.
Slovenian: Ni dokazov, da bi bilo pri bolnikih, ki imajo okužbo z virusom HIV in se zdravijo s filgrastimom, razmnoževanje virusa HIV hitrejše.