FrancophonIA/ELRC3.0 huggingface dataset:
English: Approximately 10 weeks after discontinuation of prolonged-release exenatide therapy, mean plasma exenatide concentrations fell below minimal detectable concentrations.
Croatian: Približno 10 tjedana nakon prekida terapije eksenatidom s produljenim oslobađanjem, srednje vrijednosti koncentracija eksenatida u plazmi pale su ispod najnižih mjerljivih koncentracija.
English: In a 2-year rat carcinogenicity study with prolonged-release exenatide, an increased incidence of C-cell adenomas and C-cell carcinomas was observed at doses ≥2-fold the human systemic exposure based on AUC.
Croatian: U 2-godišnjem ispitivanju kancerogeneze na štakorima kod primjene eksenatida s produljenim oslobađanjem, opažena je povećana incidencija adenoma C-stanica i karcinoma C-stanica pri dozama kojima je postignuta izloženost ≥ 2 puta veća od sistemske izloženosti u ljudi na temelju AUC-a.
English: This medicine is used in combination with the following diabetes medicines: metformin, sulphonylureas, thiazolidinediones, SGLT2 inhibitors and/or a long-acting insulin.
Croatian: Ovaj lijek se primjenjuje u kombinaciji sa sljedećim lijekovima za liječenje šećerne bolesti: metforminom, sulfonilurejama, tiazolidindionima, SGLT2 inhibitorima i/ili inzulinom dugog djelovanja.
English: - The other ingredients are: - In the powder: poly (D,L-lactide-co-glycolide) and sucrose.
Croatian: - Drugi sastojci su: - U prašku: poli(D,L-laktid-ko-glikolid) i saharoza.
English: Small subcutaneous injection site nodules were observed very frequently in clinical studies, consistent with the known properties of poly (D,L-lactide co-glycolide) polymer microsphere formulations.
Croatian: Mali potkožni čvorići na mjestu injekcije opaženi su vrlo često u kliničkim ispitivanjima, što je u skladu s poznatim svojstvima formulacija s poli (D,L-laktid ko-glikolidnim) polimernim mikrosferama.
English: The suspension should only be used if it is evenly mixed, white to off-white and cloudy, with no white medicine seen along the side, bottom or top of the pen window.
Croatian: Suspenzija se smije primijeniti samo ako je bijele do bjelkaste boje i mutna te jednoliko pomiješana, bez vidljivih bijelih tragova lijeka na stijenkama, dnu i vrhu prozorčića na brizgalici.
English: What should I do if I see air bubbles in the pen?
Croatian: Što trebam učiniti ako u brizgalici vidim mjehuriće zraka?
English: EXSCEL was a pragmatic cardiovascular (CV) outcome study in patients with type 2 diabetes and any level of CV risk.
Croatian: Ispitivanje EXSCEL bilo je ispitivanje kardiovaskularnih (KV) ishoda u bolesnika sa šećernom bolešću tipa 2 i bilo kojom razinom KV rizika u svakodnevnoj kliničkoj praksi.
English: The orange connector will keep it attached to the syringe.
Croatian: Narančasti priključak je drži pričvršćenom za štrcaljku.
English: If a dose is missed and the next regularly scheduled dose is due 1 or 2 days later, the patient should not administer the missed dose, but instead resume prolonged-release exenatide on the next regularly scheduled dosing day.
Croatian: Ako bolesnik propusti dozu, a sljedeću dozu prema rasporedu treba primijeniti 1 ili 2 dana kasnije, ne smije primijeniti propuštenu dozu, već treba nastaviti s primjenom eksenatida s produljenim oslobađanjem na dan kada ga treba primijeniti prema uobičajenom rasporedu.
English: This medicine is provided as a powder and solvent (liquid) for suspension for injection in a pre-filled pen.
Croatian: Ovaj lijek dolazi u obliku praška i otapala (tekućine) za suspenziju za injekciju u napunjenoj brizgalici.
English: A mean increase in heart rate (HR) of 2.4 beats per minute (bpm) from baseline (74 bpm) was observed in the controlled period of the Bydureon BCise clinical studies.
Croatian: Srednje povećanje srčane frekvencije od 2,4 otkucaja po minuti od početne vrijednosti (74 otkucaja po minuti) primijećeno je u kontroliranom razdoblju kliničkih ispitivanja lijeka Bydureon BCise.
English: Prior to use of the pen, it is recommended that you should be trained by a doctor or diabetes nurse on its proper use.
Croatian: Prije nego što upotrijebite brizgalicu, preporučuje se da Vas o njezinoj pravilnoj uporabi obuči liječnik ili medicinska sestra u dijabetološkoj ambulanti.
English: Posology The recommended dose is 2 mg exenatide once weekly.
Croatian: Doziranje Preporučena doza je 2 mg eksenatida jednom tjedno.
English: You can also change your chosen injection day, as long as your last dose was given 3 or more days before.
Croatian: Isto tako, možete promijeniti i izabrani dan u tjednu, pod uvjetom da ste posljednju dozu primijenili prije najmanje 3 dana.
English: Wash your hands while the pen is warming up.
Croatian: Dok se brizgalica grije, operite ruke.
English: For all patients completing the uncontrolled study extension of 7 years (n = 122 of 258 patients included in the extension phase), HbA1c gradually increased over time from Week 52 onwards, but was still reduced compared to baseline after 7 years (-1.5%).
Croatian: Svim bolesnicima koji su završili nastavak ispitivanja bez kontrolne skupine, u trajanju od 7 godina (n=122 od 258 bolesnika uključenih u fazu nastavka), HbA1c se postupno povećao tijekom vremena od 52. tjedna nadalje, ali je i dalje, nakon 7 godina, bio smanjen u odnosu na početnu vrijednost (-1,5%).
English: with the needle attached, in a puncture-resistant container.
Croatian: s pričvršćenom iglom u neprobojan spremnik.
English: It may also help to tap the mixing window on both sides against your palm.
Croatian: Možda će pomoći i ako objema stranama prozorčića za miješanje lupkate o dlan.
English: One needle is a spare.
Croatian: Jedna igla je rezervna.
English: In addition, hypoglycaemia with a sulphonylurea occurred very commonly (see Description of selected adverse reactions, below).
Croatian: Osim toga, kod primjene sa sulfonilurejom vrlo se često javljala hipoglikemija (vidjeti „Opis odabranih nuspojava“ u nastavku).
English: #nominal p-value <0.05,
Croatian: #nominalna p-vrijednost < 0,05,
English: With your thumb, push down the plunger until it stops and hold your thumb in place.
Croatian: Palcem potisnite klip prema dolje dok se ne zaustavi i zadržite palac na mjestu.
English: This reduction in body weight was seen irrespective of the occurrence of nausea although the reduction was larger in the group with nausea (mean reduction of -1.9 kg to -5.2 kg with nausea versus -1.0 kg to -2.9 kg without nausea).
Croatian: To je smanjenje tjelesne težine viđeno bez obzira na pojavu mučnine, iako je smanjenje bilo veće u skupini bolesnika koji su imali mučninu (srednja vrijednost smanjenja od -1,9 kg do -5,2 kg s mučninom, naspram -1,0 kg do -2,9 kg bez mučnine).
English: A pharmacodynamic study with exenatide demonstrated in patients with type 2 diabetes (n = 13) a restoration of first phase insulin secretion and improved second phase insulin secretion in response to an intravenous bolus of glucose.
Croatian: Farmakodinamičko ispitivanje s eksenatidom pokazalo je da se u bolesnika sa šećernom bolešću tipa 2 (n=13), kao odgovor na intravenski bolus glukoze, ponovno uspostavlja prva faza lučenja inzulina i poboljšava druga faza lučenja inzulina.
English: No clinically meaningful differences were observed in steady state exenatide concentrations or tolerability in patients with mild to moderate renal impairment (eGFR 30 to 89 ml/min/1.73m receiving Bydureon BCise, compared to those with normal renal function.
Croatian: Nisu opažene klinički značajne razlike u koncentracijama eksenatida u stanju dinamičke ravnoteže ili njegovoj podnošljivosti u bolesnika s blagim do umjerenim oštećenjem bubrega (eGFR od 30 do 89 ml/min/1,73 m2) koji su primali Bydureon BCise u odnosu na bolesnike s normalnom bubrežnom funkcijom.
English: You can inject each dose of the medicine in your stomach area (abdomen), your thigh, or the back of your upper arm.
Croatian: Svaku dozu lijeka možete injicirati u područje trbuha (abdomena), u bedro ili u stražnju stranu nadlaktice.
English: Important: After the medicine is fully mixed, you must complete the preparation steps right away, and inject to get the full dose.
Croatian: Važno: Nakon što dobro promiješate lijek, morate odmah dovršiti pripremne korake i injicirati lijek, da biste primili cijelu dozu.
English: DO NOT proceed unless needle is attached
Croatian: NE SMIJETE nastaviti ako igla nije pričvršćena
English: Patients on pioglitazone gained weight (Table 6).
Croatian: Bolesnici na pioglitazonu su dobili na tjelesnoj težini (Tablica 6).
English: Very common side effects (may affect more than 1 in 10 people)
Croatian: Vrlo česte nuspojave (mogu se javiti u više od 1 na 10 osoba):
English: The medicine is injected into your skin (subcutaneously).
Croatian: Lijek se injicira pod kožu (supkutano).
English: In clinical studies of prolonged-release exenatide, approximately 45% of patients had low titre antibodies to exenatide at study endpoint.
Croatian: U kliničkim ispitivanjima eksenatida s produljenim oslobađanjem otprilike 45% bolesnika imalo je nizak titar protutijela na eksenatid na ishodu ispitivanja.
English: Where to learn more about Bydureon
Croatian: Gdje možete saznati više o lijeku Bydureon
English: When prolonged-release exenatide is used in combination with a sulphonylurea, patients should be advised to take precautions to avoid hypoglycaemia while driving and using machines.
Croatian: Kada se eksenatid s produljenim oslobađanjem primjenjuje u kombinaciji sa sulfonilurejom, bolesnicima treba savjetovati da poduzmu mjere opreza kako bi izbjegli hipoglikemiju za vrijeme upravljanja vozilima i rada sa strojevima.
English: After discontinuation, the effect of prolonged-release exenatide may continue as plasma levels of exenatide decline over 10 weeks.
Croatian: Nakon obustave liječenja učinak eksenatida s produljenim oslobađanjem može trajati sve dok se tijekom 10 tjedana ne snize plazmatske razine eksenatida.
English: A reduction in HbA1c was observed over the course of the trial with an overall treatment difference of -0.53% (prolonged-release exenatide vs. placebo).
Croatian: Tijekom ispitivanja opaženo je sniženje vrijednosti HbA1c, a ukupna razlika između liječenja iznosila je -0,53% (eksenatid s produljenim oslobađanjem naspram placeba).
English: No dose adjustment is necessary for patients with mild renal impairment (creatinine clearance 50 to 80 ml/min).
Croatian: Nije potrebno prilagođavati dozu za bolesnike s blagim oštećenjem bubrega (klirens kreatinina 50 do 80 ml/min).
English: For instructions on the suspension of the medicinal product before administration, see section 6.6 and the “Instructions for the User”.
Croatian: Za uputu o pripremi suspenzije lijeka prije primjene vidjeti dio 6.6 i „Upute za korisnika“.
English: Patients on pioglitazone gained weight (Table 4).
Croatian: Bolesnici na pioglitazonu su dobili na tjelesnoj težini (Tablica 4).
English: The need for additional antihyperglycaemic medication was reduced by 33% % with the prolongedrelease exenatide group (exposure-adjusted incidence of 10.5 per 100 pt-year) compared to the placebo group (exposure-adjusted incidence of 15.7 per 100 pt-year).
Croatian: Potreba za uvođenjem dodatnog antihiperglikemika smanjila se za 33% u skupini liječenoj eksenatidom s produljenim oslobađanjem (incidencija prilagođena za izloženost: 10,5 na 100 bolesnik-godina) u usporedbi sa skupinom koja je primala placebo (incidencija prilagođena za izloženost: 15,7 na 100 bolesnik-godina).
English: Hepatic impairment No dose adjustment is necessary for patients with hepatic impairment (see section 5.2).
Croatian: U bolesnika s oštećenjem jetre nije potrebna prilagodba doze (vidjeti dio 5.2).
English: Pick up the vial connector package and peel off the paper cover.
Croatian: Uzmite omot s priključkom za bočicu i odlijepite papirnati pokrov.
English: Pharmacotherapeutic group: Drugs used in diabetes, glucagon-like peptide-1 (GLP-1) analogues, ATC code: A10BJ01.
Croatian: Farmakoterapijska skupina: Lijekovi za liječenje šećerne bolesti, Analozi receptora peptida-1 nalik glukagonu (GLP-1), ATK oznaka: A10BJ01.
English: When you unscrew the orange cap, the green shield keeps the needle covered until you inject.
Croatian: Nakon što skinete narančasti zatvarač, zeleni zaštitni pokrov prekriva iglu sve do injiciranja lijeka.
English: Do not throw away the pen in your household waste.
Croatian: Nemojte baciti brizgalicu u kućni otpad.
English: Exenatide suppresses glucagon secretion which is known to be inappropriately elevated in patients with type 2 diabetes.
Croatian: Eksenatid potiskuje lučenje glukagona, koje je neprimjereno povećano u bolesnika sa šećernom bolešću tipa
English: Hold the pen up to the light and look through both sides of the mixing window.
Croatian: Usmjerite brizgalicu prema svjetlu i pogledajte kroz obje strane prozorčića za miješanje.
English: Patients (%) achieving HbA1c ≤ 7% 62
Croatian: Bolesnici (%) koji su postigli HbA1c ≤ 7% 62
English: If you have questions about taking Bydureon
Croatian: Ako imate pitanja o primjeni lijeka Bydureon
English: Throw away any Bydureon kit that has been frozen.
Croatian: Svaki set lijeka Bydureon koji je bio zamrznut mora se baciti.
English: Orange Label
Croatian: Narančasta naljepnica
English: Following weekly administration of 2 mg Bydureon BCise, mean exenatide concentrations exceeded minimal efficacious concentrations (~ 50 pg/ml) in 2 weeks with gradual increase in the average plasma exenatide concentration up to Week 8.
Croatian: Nakon tjedne primjene lijeka Bydureon BCise u dozi od 2 mg, srednja vrijednost koncentracije eksenatida premašila je najniže djelotvorne koncentracije (~ 50 pg/ml) u 2 tjedna, s daljnjim postupnim povećanjem prosječne koncentracije eksenatida u plazmi do 8. tjedna.
English: Step 1: Prepare your pen
Croatian: 1. korak: Pripremite brizgalicu
English: Exenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that exhibits several antihyperglycaemic actions of glucagon-like peptide-1 (GLP-1).
Croatian: Eksenatid je agonist receptora peptida-1 nalik glukagonu (engl. glucagon-like peptide-1, GLP-1) koji iskazuje nekoliko antihiperglikemijskih djelovanja peptida-1 nalik glukagonu (GLP-1).
English: Be sure to use the injection technique recommended by your doctor or diabetes nurse.
Croatian: Svakako primijenite tehniku injiciranja koju su Vam preporučili liječnik ili medicinska sestra u dijabetološkoj ambulanti.
English: Do not use this medicine after the expiry date, which is stated on the label and the carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici i kutiji iza oznake “EXP“ ili „Rok valjanosti“.
English: • Keep holding the pen against the skin for 15 seconds.
Croatian: • Držite brizgalicu pritisnutu na kožu 15 sekundi.
English: DO NOT proceed unless your medicine is mixed well
Croatian: NE SMIJETE nastaviti ako otopina nije dobro pomiješana
English: Your doctor or diabetes nurse should teach you how to inject this medicine before you use it for the first time.
Croatian: Prije prve primjene Vaš liječnik ili medicinska sestra u dijabetološkoj ambulanti moraju Vas naučiti kako ćete injicirati ovaj lijek.
English: Subcutaneous injection site nodules were observed frequently in clinical studies, consistent with the known properties of poly (D,L-lactide co-glycolide) polymer microsphere formulations.
Croatian: Potkožni čvorići na mjestu injekcije opaženi su često u kliničkim ispitivanjima, što je u skladu s poznatim svojstvima formulacija s poli (D,L-laktid ko-glikolidnim) polimernim mikrosferama.
English: The powder (2 mg) in one chamber, is white to off-white and the solvent (0.65 ml) in the other chamber, is a clear, colourless to pale yellow to pale brown solution.
Croatian: U jednoj se komori nalazi prašak (2 mg) bijele do bjelkaste boje, a u drugoj otapalo (0,65 ml), koje je bistra, bezbojna do blijedožuta ili blijedosmeđa otopina.
English: The following interaction studies have been conducted using 10 mcg immediate-release exenatide but not prolonged-release exenatide formulations:
Croatian: Sljedeća ispitivanja interakcija provedena su s eksenatidom s trenutnim oslobađanjem u dozi od 10 µg, ali ne i s formulacijama eksenatida s produljenim oslobađanjem:
English: If you see white medicine, it is unmixed.
Croatian: Ako vidite bijele tragove, lijek nije dobro promiješan.
English: For single-use only
Croatian: Samo za jednokratnu uporabu.
English: When added to sulphonylurea therapy, a reduction in the dose of sulphonylurea should be considered to reduce the risk of hypoglycaemia (see section 4.4).
Croatian: Kada se dodaje terapiji sulfonilurejom, treba razmotriti smanjenje doze sulfonilureje kako bi se smanjio rizik od hipoglikemije (vidjeti dio 4.4).
English: However, as renal function generally declines with age, consideration should be given to the patient's renal function (see Renal impairment) (see section 5.2).
Croatian: Međutim, budući da se bubrežna funkcija uglavnom smanjuje s dobi, treba uzeti u obzir bolesnikovu bubrežnu funkciju (vidjeti Oštećenje bubrega). (vidjeti dio 5.2).
English: − Is a single use, fixed dose pen that automatically injects your medicine.
Croatian: Namijenjena je za jednokratnu uporabu, sadrži fiksnu dozu i automatski injicira lijek.
English: To inject your full dose, push down on the plunger with your thumb until it stops.
Croatian: Kako biste injicirali čitavu dozu, palcem potisnite klip dok se ne zaustavi.
English: Prolonged-release exenatide is for self-administration by the patient.
Croatian: Eksenatid s produljenim oslobađanjem namijenjen je za samoprimjenu od strane bolesnika.
English: Frequency reported from the 28-week controlled treatment period of the prolonged-release exenatide as add-on to insulin glargine study (N=231).
Croatian: Učestalost prijavljena iz 28-tjednog kontroliranog perioda liječenja eksenatidom s produljenim oslobađanjem kao dodatka inzulinu glarginu (N=231).
English: The dose of your sulphonylurea medicine may need to be reduced while you use this medicine.
Croatian: Možda će trebati smanjiti dozu lijeka koji sadrži sulfonilureju tijekom liječenja ovim lijekom.
English: 1 pre-filled syringe of 0.65 ml solvent 1 vial connector
Croatian: 1 napunjenu štrcaljku s 0,65 ml otapala 1 priključak za bočicu
English: Includes acute renal failure, worsened chronic renal failure, renal impairment, increased serum creatinine.
Croatian: Uključuje akutno zatajenje bubrega, pogoršanje kroničnog zatajenja bubrega, poremećaj funkcije bubrega, povišene razine kreatinina u serumu.
English: Solvent for Bydureon
Croatian: Otapalo za Bydureon
English: Hydroxy methyl glutaryl coenzyme A reductase inhibitors Lovastatin AUC and Cmax were decreased approximately 40% and 28%, respectively, and tmax was delayed about 4 h when immediate-release exenatide was administered concomitantly with a single dose of lovastatin (40 mg) compared with lovastatin administered alone.
Croatian: Inhibitori hidroksimetilglutaril koenzim A reduktaze Kad je eksenatid s trenutnim oslobađanjem primijenjen istodobno s jednom dozom lovastatina (40 mg), AUC lovastatina smanjen je za približno 40%, a Cmax za približno 28%, dok je tmax odgođen za oko 4 sata u usporedbi s primjenom samog lovastatina.
English: Prolonged-release exenatide 2 mg + Insulin glargine
Croatian: Eksenatid s produljenim oslobađanjem 2 mg + inzulin glargin
English: Do not remove the needle cover yet.
Croatian: Još nemojte skidati poklopac s igle.
English: If you use this medicine in combination with a sulphonylurea, low blood sugar (hypoglycaemia) can occur.
Croatian: Ako primjenjujete ovaj lijek u kombinaciji sa sulfonilurejom, može doći do niskog šećera u krvi (hipoglikemije).
English: In a single-dose pharmacokinetic study of immediate-release exenatide in 13 patients with type 2 diabetes and between the ages of 12 and 16 years, administration of exenatide (5 mcg) resulted in slightly lower mean AUC (16% lower) and Cmax (25% lower) compared to those observed in adults.
Croatian: U farmakokinetičkom ispitivanju s primjenom jedne doze eksenatida s trenutnim oslobađanjem u 13 bolesnika sa šećernom bolešću tipa 2 u dobi između 12 i 16 godina, primjena eksenatida (5 µg) rezultirala je nešto nižom srednjom vrijednošću AUC-a (16% niže) i Cmax (25% niže) u usporedbi s vrijednostima opaženih u odraslih.
English: WAIT
Croatian: PRIČEKAJTE
English: Treatment with prolonged-release exenatide persistently significantly improved glycaemic control and weight control, compared to the insulin glargine treatment.
Croatian: Liječenje eksenatidom s produljenim oslobađanjem je uvijek značajno poboljšalo kontrolu glikemije i tjelesne težine, u usporedbi s liječenjem inzulinom glarginom.
English: Most adverse reactions were mild to moderate in intensity.
Croatian: Većina nuspojava bila je blagog do umjerenog intenziteta.
English: The reactions are listed below as MedDRA preferred term by system organ class and absolute frequency.
Croatian: Nuspojave su navedene prema MedDRA preporučenim pojmovima i prema klasifikaciji organskih sustava i apsolutnoj učestalosti.
English: STEP 3: Prepare the Pen
Croatian: 3. KORAK: Pripremite brizgalicu
English: To get a full dose, the medicine must be mixed well and look cloudy.
Croatian: Da biste primili cijelu dozu, lijek mora biti dobro promiješan i mora izgledati mutno.
English: Nervous system disorders Headache
Croatian: Poremećaji živčanog sustava glavobolja omaglica disgeuzija somnolencija
English: C. Check the liquid, inside the inspection window.
Croatian: unutar prozorčića za provjeru.
English: Following weekly administration of 2 mg prolonged-release exenatide, mean exenatide concentrations exceeded minimal efficacious concentrations (~ 50 pg/ml) in 2 weeks with gradual increase in the average plasma exenatide concentration over 6 to 7 weeks.
Croatian: Nakon tjedne primjene eksenatida s produljenim oslobađanjem u dozi od 2 mg, srednja vrijednost koncentracije eksenatida premašila je najniže djelotvorne koncentracije (~ 50 pg/ml) u 2 tjedna, s daljnjim postupnim povećanjem prosječne koncentracije eksenatida u plazmi tijekom 6 do 7 tjedana.
English: Each dose should be administered in the abdomen, thigh, or the back of the upper arm as a subcutaneous injection immediately after the medicinal product is fully mixed.
Croatian: Svaka se doza mora primijeniti supkutanom injekcijom u područje abdomena, bedra ili stražnjeg dijela nadlaktice odmah nakon što se lijek potpuno pomiješa.
English: Insulin glargine was dosed to a target glucose concentration of 4.0 to 5.5 mmol/l (72 to 100 mg/dl).
Croatian: Inzulin glargin bio je doziran prema ciljnoj koncentraciji glukoze od 4,0 do 5,5 mmol/l (72 do 100 mg/dl).
English: How do I know I gave myself the full dose of medicine?
Croatian: Kako ću znati jesam li primijenio/la cijelu dozu lijeka?
English: To reduce the risk of hypoglycaemia associated with the use of a sulphonylurea, reduction in the dose of sulphonylurea may be considered (see sections 4.2 and 4.4).
Croatian: Kako bi se smanjio rizik od hipoglikemije povezane s uzimanjem sulfonilureje, može se razmotriti smanjenje doze sulfonilureje (vidjeti dijelove 4.2 i 4.4).
English: The powder is white to off-white and the solvent is a clear, colourless to pale yellow to pale brown solution.
Croatian: Prašak je bijele do bjelkaste boje, a otapalo je bistra, bezbojna do blijedožuta ili blijedosmeđa otopina.
English: The improvement in fasting plasma glucose concentrations was durable through 52 weeks.
Croatian: Poboljšanje koncentracija glukoze u plazmi natašte održalo se tijekom 52 tjedna.
English: IMPORTANT Once the medicine is mixed well, you must inject the dose immediately.
Croatian: Nakon što dobro pomiješate lijek, morate odmah injicirati dozu.
English: Keep pushing down on the plunger with your thumb and shake vigorously.
Croatian: Nastavite pritiskati klip palcem i snažno tresite.
English: Prolonged-release exenatide demonstrated superiority to both sitagliptin and pioglitazone with respect to change in HbA1c from baseline.
Croatian: Eksenatid s produljenim oslobađanjem se pokazao superiornim i od sitagliptina i od pioglitazona s obzirom na promjene HbA1c u odnosu na početne vrijednosti.