FrancophonIA/ELRC3.0 huggingface dataset:
English: In a double-blind, randomized comparator-controlled study (Study 044) of similar design to Study 043 conducted in opioid-tolerant patients with breakthrough cancer pain on stable doses of regularly scheduled opioids, PecFent was shown to be superior to immediate-release morphine sulfate (IRMS).
Slovenian: V dvojno slepi, randomizirani študiji, kontrolirani s primerjalnim zdravilom (študija 044), s podobno zasnovo kot študija 043, opravljeni pri bolnikih, tolerantnih za opioide, s prebijajočo bolečino zaradi raka, na stabilnih, redno razporejenih odmerkih opioidov so pokazali, da je zdravilo PecFent boljše od morfinovega sulfata s takojšnjim sproščanjem (IRMS).
English: If the spray has not been used within 5 days after priming, the bottle should be discarded.)
Slovenian: Če pršila ne porabite v 5 dneh po aktivaciji, morate steklenico zavreči.)
English: Breakthrough pain is a transitory exacerbation of pain that occurs on a background of otherwise controlled persistent pain.
Slovenian: Prebijajoča bolečina je prehoden izbruh bolečine, ki se dodatno pojavi ob sicer obvladani dolgotrajni bolečini.
English: PecFent is only to be used by adults who are already taking other opioid medicines daily for their constant cancer pain.
Slovenian: Zdravilo PecFent naj uporabljajo samo odrasli, ki vsak dan že jemljejo druga opioidna zdravila za stalno bolečino zaradi raka.
English: Keep out of the sight and reach of children (Figure 6)
Slovenian: Zdravilo shranjujte zunaj dosega in pogleda otrok (slika 6).
English: • From treatment initiation, patients should be closely followed and the dose titrated until an effective dose is reached and confirmed for two consecutively treated episodes of BTP.
Slovenian: • Od uvedbe zdravljenja naprej moramo bolnike skrbno spremljati in titrirati odmerek, dokler ne dosežemo učinkovitega odmerka in ga ne potrdimo v dveh zaporedno zdravljenih epizodah
English: • misusing the medicine
Slovenian: • napačna uporaba zdravila,
English: The effect of renal or hepatic impairment on the pharmacokinetics of PecFent has not been studied.
Slovenian: Učinka okvare ledvic ali jeter na farmakokinetiko zdravila PecFent niso proučevali.
English: If serotonin syndrome is suspected, treatment with PecFent should be discontinued.
Slovenian: Pri sumu na serotoninski sindrom je treba zdravljenje z zdravilom PecFent prekiniti.
English: • The pharmacist must inform the patients that in order to prevent theft and misuse of PecFent nasal spray they have to keep it in a safe place to avoid misuse and diversion
Slovenian: • farmacevt mora obvestiti bolnike, da morajo zaradi preprečevanja kraje in nepravilne uporabe pršila nos PecFent to zdravilo hraniti na varnem mestu, da preprečijo nepravilno uporabo in uvedbo zdravila na nezakoniti trg;
English: Uncommon side effects: (may affect up to 1 in 100 people):
Slovenian: Občasni neželeni učinki (pojavijo se lahko pri do 1 od 100 bolnikov):
English: The concomitant use of partial opioid agonists/antagonists (e.g. buprenorphine, nalbuphine, pentazocine) is not recommended.
Slovenian: Sočasna uporaba delnih opioidnih agonistov/antagonistov (npr. buprenorfina, nalbufina, pentazocina) ni priporočljiva.
English: The concomitant use of other central nervous system depressants, including other opioids, sedatives or hypnotics, general anaesthetics, phenothiazines, tranquillisers, skeletal muscle relaxants, sedating antihistamines and alcohol may produce additive depressant effects.
Slovenian: Sočasna uporaba drugih depresorjev centralnega živčevja, vključno z drugimi opioidi, sedativi ali hipnotiki, splošnimi anestetiki, fenotiazini, pomirjevali, relaksanti skeletnih mišic, sedativnimi antihistaminiki in alkoholom, lahko povzroči dodatne depresorne učinke.
English: You will hear a second ‘click' and there should now be a single large red bar in the counting window (Figure 3b).
Slovenian: Slišali boste še en ‘klik', v okencu števca pa boste zdaj videli en sam velik rdeč stolpec (slika 3b).
English: An audible click will be heard and the number displayed on the counter will advance by one.
Slovenian: Zasliši se klik, število, vidno v okencu števca, pa se bo zvečalo za eno.
English: Although muscle rigidity interfering with respiration has not been seen following the use of PecFent, this is possible with fentanyl and other opioids.
Slovenian: Čeprav po uporabi zdravila PecFent niso ugotavljali rigidnosti mišic, ki bi ovirala dihanje, je to možno pri fentanilu in drugih opioidih.
English: During the longer-term, open-label study (CP045) this was 6.0 % of 42,227 episodes in 355 patients treated with PecFent during up to 159 days of treatment.
Slovenian: Med dolgoročnejšo odprto študijo (CP045) je to predstavljalo 6,0 % od 42.227 epizod pri 355 bolnikih, zdravljenih z zdravilom PecFent med največ 159 dnevi zdravljenja.
English: • Do not use for more than 5 days after first use (either priming or using to treat a breakthrough pain episode).
Slovenian: • Zdravila ne uporabljajte več kot 5 dni po prvi uporabi (bodisi aktiviranju bodisi uporabi za blaženje epizode prebijajoče bolečine).
English: Fentanyl is highly lipophilic and is well distributed beyond the vascular system, with a large apparent volume of distribution.
Slovenian: Fentanil je zelo lipofilen in se dobro porazdeljuje zunaj žilja z velikim navideznim porazdelitvenim volumnom.
English: • The prescribers of PecFent nasal spray must critically select the patients and closely follow o Instructions for use of the nasal spray device o Instructions for opening and closing of the child-resistant box o Information on the correct indication
Slovenian: • Zdravniki, ki predpisujejo pršilo za nos PecFent, morajo izbirati bolnike po strogih merilih in natančno slediti o navodilom za uporabo pršila za nos; o navodilom za odpiranje in zapiranje vsebnika, varnega za otroke; o informacijam o pravilni indikaciji.
English: Other medicines and PecFent
Slovenian: Druga zdravila in zdravilo PecFent
English: • Do not use for more than 60 days after first use (either priming or using to treat a breakthrough pain episode).
Slovenian: • Zdravila ne uporabljajte več kot 60 dni po prvi uporabi (bodisi aktiviranju bodisi uporabi za blaženje epizode prebijajoče bolečine).
English: • This is a single spray into one nostril from the 100 microgram per spray bottle.
Slovenian: • To je en sam vpih v eno nosnico iz steklenice s 100 mikrogrami na vpih.
English: • If the spray is blocked, aim the spray away from you (and any other people) and push firmly down on the pump.
Slovenian: • Če je pršilo blokirano, usmerite razpršilno šobo proč od sebe (in drugih ljudi) in čvrsto pritisnite na črpalko.
English: A new bottle of PecFent will show two red lines in the counting window in the white plastic top on the bottle (Figure 1 and Figure 3a).
Slovenian: Nova steklenica zdravila PecFent ima v okencu števca, ki je v belem plastičnem vrhu steklenice, dve rdeči črtici (sliki 1 in 3a).
English: fentanyl, oxycodone or hydromorphone) to control your constant background pain.
Slovenian: oksikodon ali hidromorfon) za obvladovanje stalne osnovne bolečine.
English: Dose-proportionality was demonstrated for Cmax and AUC in the dose range 100 micrograms to 800 micrograms.
Slovenian: Dokazali so sorazmernost odmerku za Cmax in AUC v razponu odmerkov od 100 mikrogramov do 800 mikrogramov.
English: PecFent is only intended for nasal use, and must not be administered by any other route.
Slovenian: Zdravilo PecFent je namenjeno samo za nazalno uporabo in ga ni dovoljeno uporabljati na noben drug način.
English: In these patients, opioids may decrease respiratory drive and increase airway resistance.
Slovenian: Pri teh bolnikih lahko opioidi zmanjšajo dihalne spodbude in zvečajo upornost dihalnih poti.
English: • Patients whose initial dose is 100 micrograms and who need to titrate to a higher dose due to a lack of effect can be instructed to use two 100 microgram sprays (one in each nostril) for their next BTP episode.
Slovenian: • Bolnikom, katerih začetni odmerek je 100 mikrogramov in ki se morajo zaradi pomanjkanja učinka titrirati na večji odmerek, lahko naročimo, naj pri naslednji epizodi BTP uporabijo dva
English: Finding the right dose
Slovenian: Ugotavljanje pravilnega odmerka
English: It has been 60 days or more since you primed or used your bottle for the first time.
Slovenian: • je preteklo 60 dni ali več od takrat, ko ste steklenico prvič 'aktivirali' (pripravili za uporabo) ali uporabili.
English: There was no clinically significant effect of acute rhinitis on Cmax, Tmax or overall exposure to fentanyl, comparing the unchallenged with the acutely challenged states.
Slovenian: Akutni rinitis ni klinično pomembno vplival na Cmax, Tmax ali celotno izpostavljenost fentanilu, če so primerjali neprovocirano stanje z akutno izzvanim stanjem.
English: The influence of hepatic and renal impairment on the pharmacokinetics of the medicinal product has not been evaluated; however, when administered intravenously the clearance of fentanyl has been shown to be altered in hepatic and renal impairment due to alterations in metabolic clearance and plasma proteins.
Slovenian: Vpliva okvar jeter in ledvic na farmakokinetiko zdravila niso ovrednotili; vendar je dokazano, da se pri okvarah jeter in ledvic pri intravenski uporabi očistek fentanila spremeni zaradi sprememb presnovnega očistka in plazemskih beljakovin.
English: • you have liver or kidney problems.
Slovenian: • imate težave z jetri ali ledvicami.
English: If switching to PecFent from another fentanyl product for BTP, independent dose titration with PecFent is required as the bioavailability between products differs significantly.
Slovenian: Če bolnik prehaja na zdravilo PecFent z drugega zdravila s fentanilom za BTP, je potrebna neodvisna titracija odmerka z zdravilom PecFent, ker se biološka uporabnost različnih zdravil pomembno razlikuje.
English: • get cold clammy skin, look pale, have a weak pulse or other signs of shock.
Slovenian: • če dobite hladno vlažno kožo, postanete bledi, imate šibek srčni utrip ali druge znake šoka.
English: Name and address of the manufacturer responsible for batch release L. Molteni & C dei F. LLi Alitti Societá di Esercizio S.p.A Strada Statale 67
Slovenian: L. Molteni & C dei F. LLi Alitti Societá di Esercizio S.p.A Strada Statale 67
English: In severe cases taking too much PecFent may also lead to coma.
Slovenian: V hudih primerih lahko prevelik odmerek zdravila PecFent povzroči tudi komo.
English: • Do not use PecFent during child birth.
Slovenian: • Ne uporabljajte zdravila PecFent med porodom.
English: • A dose to treat a breakthrough pain episode might be either 1 spray or 2 sprays (one in each nostril).
Slovenian: • Odmerek za blaženje prebijajoče bolečine je lahko 1 vpih ali 2 vpiha (po eden v vsako nosnico).
English: • feeling tired or weak, problems moving
Slovenian: • utrujenost ali oslabelost, težave z gibanjem,
English: • you feel that PecFent is becoming less effective in treating your episodes of breakthrough pain
Slovenian: • imate občutek, da postaja zdravilo PecFent manj učinkovito za zdravljenje obdobij prebijajoče bolečine;
English: Patients should not use more than 4 doses per day.
Slovenian: Bolniki ne smejo uporabiti več kot 4 odmerke na dan. Bolniki morajo počakati vsaj 4 ure po odmerku,
English: The variability of the pharmacokinetics of fentanyl was considerable following treatment with both PecFent and OTFC.
Slovenian: Variabilnost farmakokinetike fentanila je bila po zdravljenju tako z zdravilom PecFent kot z OTFC znatna.
English: PecFent utilises the PecSys nasal drug delivery system to modulate the delivery and absorption of fentanyl.
Slovenian: Zdravilo PecFent uporablja sistem nazalne uporabe zdravila za modulacijo aplikacije in absorpcije fentanila.
English: Product strength (micrograms)
Slovenian: Jakost zdravila (mikrogrami)
English: • If you use more PecFent than you should, you may feel sleepy, sick, dizzy or have slow or shallow breathing.
Slovenian: • Če boste uporabili večji odmerek zdravila PecFent, kot bi smeli, boste mogoče zaspani, se boste slabo počutili, boste omotični ali boste počasi ali plitvo dihali.
English: • nasal sprays to treat a stuffy nose (containing a decongestant such as oxymetazoline)
Slovenian: • pršila za nos za zdravljenje zamašenega nosu (ki vsebujejo dekongestiv, na primer oksimetazolin);
English: Careful consideration should be given to patients with hypovolaemia and hypotension.
Slovenian: Zdravljenje bolnikov s hipovolemijo in hipotenzijo je treba skrbno pretehtati.
English: Opioids may influence the hypothalamic-pituitary-adrenal or -gonadal axes.
Slovenian: Opioidi lahko vplivajo na hipotalamično-hipofizno-suprarenalno ali -gonadno os.
English: • painful, sore or inflamed throat or nose
Slovenian: • boleče ali vneto žrelo ali nos,
English: Date of priming: ……….
Slovenian: Datum prve uporabe: ..........
English: Serotoninergic medicinal products:
Slovenian: Serotoninergična zdravila
English: In a long-term, open-label, safety study (Study 045), 355 patients entered the 16-week treatment phase, during which 42,227 episodes of breakthrough cancer pain (BTP) were treated with PecFent.
Slovenian: V dolgoročni odprti študiji varnosti (študija 045) se je 335 bolnikov vključilo v fazo 16-tedenskega zdravljenja, med katero so z zdravilom PecFent zdravili 42.227 epizod prebijajoče bolečine zaradi raka (BTP).
English: • heat and circulation not working properly, hot flush or fever, chills, excessive sweating
Slovenian: • vročina ali nepravilno delovanje krvnega obtoka, vročinski valovi ali vročina, mrzlica,
English: Propylparahydroxybenzoate may cause allergic reactions (possibly delayed) and, exceptionally, bronchospasm (if the medicinal product is not correctly administered).
Slovenian: Propilparahidroksibenzoat lahko pri nekaterih bolnikih povzroča alergijske reakcije (lahko odložene), izjemoma pa bronhospazem (če zdravilo ni bilo pravilno uporabljeno).
English: One dose of PecFent may include administration of 1 spray (100 microgram or 400 microgram doses) or 2 sprays (200 microgram or 800 microgram doses) of the same strength (either 100 microgram or 400 microgram strength).
Slovenian: En odmerek zdravila PecFent lahko pomeni uporabo 1 vpiha (100-mikrogramski ali 400mikrogramski odmerek) ali 2 vpihov (200-mikrogramski ali 800-mikrogramski odmerek) iste jakosti (bodisi 100-mikrogramska bodisi 400-mikrogramska jakost).
English: • dehydration, feeling thirsty
Slovenian: • dehidracija, žeja,
English: If this dose is not successful, the patient may be instructed to increase to two 400 microgram sprays (one in each nostril).
Slovenian: Če ta odmerek ni uspešen, lahko zvečamo odmerek na dva 400-mikrogramska vpiha (po enega v vsako nosnico).
English: Fentanyl diffuses from the gel and is absorbed through the nasal mucosa; this gel-modulated absorption of fentanyl restrains the peak in plasma concentration (Cmax) whilst allowing the attainment of an early time to that peak (Tmax).
Slovenian: Fentanil difundira iz gela in se absorbira skozi nosno sluznico; ta z gelom modulirana absorpcija fentanila zniža vrh plazemske koncentracije (Cmax), hkrati pa omogoči, da se ta vrh hitro doseže
English: Fentanyl is an opioid analgesic, interacting predominantly with the opioid µ-receptor.
Slovenian: Mehanizem delovanja Fentanil je opioidni analgetik, ki medsebojno deluje pretežno z opioidnim receptorjem µ.
English: • Do not store PecFent above 25°C.
Slovenian: • Zdravilo PecFent shranjujte pri temperaturi do 25 °C.
English: Therefore, when switching between fentanyl containing medicinal products indicated for treatment of breakthrough pain, including intranasal formulations, it is essential that patients are again titrated with the new medicinal product, and not switched on a dose-for-dose (microgram-formicrogram) basis.
Slovenian: Zato je pri prehajanju z enega zdravila, ki vsebuje fentanil s takojšnjim sproščanjem in je indicirano za zdravljenje prebijajoče bolečine, vključno z zdravili za intranazalno uporabo, na drugo tako zdravilo bistveno, da bolnike ponovno titriramo z novim zdravilom, namesto da bi prešli z enega zdravila na drugega na podlagi enakega odmerka v mikrogramih.
English: [2 spray bottle:] 1 bottle - 0.95 ml (2 sprays) per bottle
Slovenian: [Steklenica z 2 vpihoma:] 1 steklenica - 0,95 ml (2 vpiha) na steklenico
English: Relative bioavailability of fentanyl from the PecFent treatment compared to the 200 microgram OTFC was approximately
Slovenian: Relativna biološka uporabnost fentanila iz zdravila PecFent v primerjavi z 200 mikrogrami OTFC je bila približno 120 %.
English: There are still doses of PecFent left in the bottle.
Slovenian: V steklenici so še ostali odmerki zdravila PecFent.
English: The patient should be advised to write the date of first use in the space provided on the label of the child resistant container.
Slovenian: Bolniku svetujte, naj zapiše datum prve uporabe zdravila na temu namenjeno mesto na etiketi vsebnika z zaporko, varno za otroke.
English: • The starting dose is 100 micrograms.
Slovenian: Začetni odmerek • Začetni odmerek je 100 mikrogramov.
English: Wipe the nozzle with a tissue and flush the tissue down the toilet.
Slovenian: Obrišite razpršilno šobo s papirnatim robčkom in ga vrzite v straniščno školjko.
English: Firmly press down on the finger grips so that PecFent sprays into your nostril.
Slovenian: Čvrsto pritisnite na sprožilec, tako da bo črpalka oddala odmerek v vašo nosnico.
English: In the randomised, placebo-controlled study (CP043) 9.4% of 459 PecFent-treated BTP episodes in 73 patients required use of any further (rescue) medicinal products within 60 minutes of dosing.
Slovenian: V randomizirani, s placebom kontrolirani študiji (CP043) je bila pri 9,4 % od 459 epizod BTP, zdravljenih z zdravilom PecFent, pri 73 bolnikih potrebna uporaba kakih drugih (rešilnih) zdravil v
English: Each bottle contains 1.55 ml (6,200 micrograms fentanyl)
Slovenian: Ena steklenica vsebuje 1,55 ml (6.200 mikrogramov fentanila).
English: The mean pain intensity scores (73 patients) for all PecFent-treated episodes (459 episodes) compared to those treated with placebo (200 episodes) were significantly lower at 5, 10, 15, 30, 45 and 60 minutes following administration (see Figure 1).
Slovenian: PecFent (459 epizod), v primerjavi z epizodami, zdravljenimi s placebom (200 epizod), so bili značilno manjši po 5, 10, 15, 30, 45 in 60 minutah od uporabe (glejte sliko 1).
English: If you use more PecFent than you should
Slovenian: Če ste uporabili večji odmerek zdravila PecFent, kot bi smeli
English: • muscle convulsions or trembling
Slovenian: • mišični krči ali drgetanje,
English: • The initial dose of PecFent to treat episodes of BTP is always 100 micrograms (one spray), even in patients switching from other fentanyl containing products for their BTP.
Slovenian: Začetni odmerek • Začetni odmerek zdravila PecFent za zdravljenje epizod BTP je vedno 100 mikrogramov (en vpih), tudi pri bolnikih, ki preidejo z drugih zdravil, ki vsebujejo fentanil, zaradi zdravljenja BTP.
English: In the PecFent clinical trial programme, 104 (26.1%) of patients were over 60 years of age, 67 (16.8%) over 65 years and 15 (3.8%) over 75 years.
Slovenian: bolnikov (16,8 %) je bilo starejših od 65 let in 15 (3,8 %) starejših od 75 let.
English: • Only use PecFent nasal spray if you have received the proper information regarding the use of the device and the safety precautions from the prescriber and/or the pharmacist
Slovenian: • pršilo za nos PecFent uporabljajte le, če ste od zdravnika, ki vam je predpisal zdravilo, in/ali od farmacevta prejeli natančne informacije o uporabi pripomočka in varnostnih ukrepih;
English: 0.95 ml ensuring delivery of 2 full sprays or
Slovenian: 0,95 ml, kar zagotavlja 2 polna vpiha ali
English: What you need to know before you use PecFent Do not use PecFent if:
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo PecFent Ne uporabljajte zdravila PecFent:
English: Any empty bottles should be returned to their child resistant container and discarded by taking them back to the pharmacy or according to local requirements.
Slovenian: Prazne steklenice shranite v vsebniku z zaporko, varno za otroke, in jih odvrzite, tako da jih vrnete v lekarno, ali v skladu z lokalnimi zahtevami.
English: • cough, sneezing, catarrh or cold, changes in the fluid produced by your nose
Slovenian: • kašelj, kihanje, nahod ali prehlad, spremembe tekočine, ki nastaja v nosu,
English: • Instructions for opening and closing of the child-resistant box
Slovenian: • navodila za odpiranje in zapiranje vsebnika, varnega za otroke;
English: 2 spray bottle:
Slovenian: Steklenica z 2 vpihoma:
English: It is advised not to use fentanyl during labour and delivery (including caesarean section) because fentanyl passes through the placenta and may cause respiratory depression in the foetus.
Slovenian: Uporabo fentanila med popadki in porodom (vključno s carskim rezom) odsvetujemo, ker fentanil prehaja skozi posteljico in lahko povzroči depresijo dihanja pri plodu.
English: 1.55 ml ensuring delivery of 8 full sprays.
Slovenian: 1,55 ml, kar zagotavlja 8 polnih vpihov.
English: PecFent contains fentanyl, which is a strong pain-relieving medicine known as an opioid pain killer.
Slovenian: Zdravilo PecFent vsebuje fentanil, ki je močno protibolečinsko zdravilo, znano kot opioidni analgetik.
English: A clear to practically clear colourless aqueous solution.
Slovenian: Bistra do skoraj bistra brezbarvna vodna raztopina.
English: What PecFent is and what it is used for What you need to know before you use PecFent How to use PecFent
Slovenian: Kaj je zdravilo PecFent in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo PecFent Kako uporabljati zdravilo PecFent
English: However, you should keep taking your other opioid medicine to treat your constant pain.
Slovenian: Vaše drugo opioidno zdravilo za blaženje vaše stalne bolečine pa morate uporabljati še naprej.
English: Dose-proportionality was demonstrated for Cmax and area under the curve (AUC) in the dose range 100 micrograms to 800 micrograms (see Figure 3).
Slovenian: Sorazmernost odmerkom so dokazali za Cmax in površino pod krivuljo (AUC) v mejah odmerkov 100 mikrogramov do 800 mikrogramov (glejte sliko 3).
English: The SPID for PecFent-treated episodes was also significantly different to placebo at 10 15, 45 and 60 minutes after administration.
Slovenian: se je tudi značilno razlikoval od placeba 10, 15, 45 in 60 minut po uporabi.
English: Not all presentations or pack sizes may be marketed.
Slovenian: Na trgu morda ni vseh navedenihoblik ali pakiranj.
English: Patients should be advised not to blow their nose immediately after PecFent administration.
Slovenian: Bolnikom morate svetovati, naj se ne usekujejo takoj po uporabi zdravila PecFent.
English: • Put the protective cap back on the spray bottle.
Slovenian: • Namestite zaščitno zaporko nazaj na steklenico s pršilom.
English: Dehydration Hyperglycaemia Decreased appetite Increased appetite
Slovenian: Presnovne in prehranske motnje dehidracija hiperglikemija zmanjšan apetit zvečan apetit
English: Therefore, special care should be taken during the titration process in patients with moderate or severe hepatic or renal impairment.
Slovenian: Zato je pri postopku titracije pri bolnikih z zmernimi ali težkimi okvarami jeter ali ledvic potrebna posebna skrbnost.
English: Put the nozzle a short distance (about 1 cm) into your nostril.
Slovenian: Vtaknite razpršilno šobo nekoliko (okrog 1 cm) v nosnico.
English: Preparing the PecFent bottle for use
Slovenian: Priprava steklenice zdravila PecFent za uporabo
English: In particular tell your doctor or pharmacist before using PecFent if you are taking or have recently taken any of the following medicines:
Slovenian: Preden uporabite zdravilo PecFent, svojega zdravnika ali farmacevta še zlasti obvestite, če uporabljate ali ste pred nedavnim uporabljali katero od naslednjih zdravil:
English: • You will need to press down and release the finger grips 4 more times while aiming the nasal spray away from you (and any other people).
Slovenian: • Še štirikrat pritisnite in spustite sprožilec in pri tem usmerite pršilo za nos proč od sebe (in drugih ljudi).