FrancophonIA/ELRC3.0 huggingface dataset:
English: Tres le Bois 22600 Loudeac France
Slovenian: Tres le Bois 22600 Loudeac Francija
English: Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Slovenian: Podrobne informacije o tem zdravilu za uporabo v veterinarski medicini so na voljo na spletni strani Evropske agencije za zdravila (European Medicines Agency, EMA) http://www.ema.europa.eu/.
English: This hypertrophy does not seem to be linked to any pathology and was observed to be reversible upon discontinuation of the treatment.
Slovenian: Ta hipertrofija ni povezana z nobeno patologijo in je bila reverzibilna po prekinitvi zdravljenja.
English: Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Slovenian: Rok uporabnosti zdravila v pakiranju za prodajo: 2 leti.
English: Manufacturers responsible for batch release: Ceva Santé Animale
Slovenian: Izdelovalec, odgovoren za sprostitev serije: Ceva Santé Animale
English: White plastic (HDPE) bottle with a child-resistant closure in a cardboard box.
Slovenian: Bela plastična (HDPE) plastenka z zapiralom varnim pred otroki v kartonski škatli.
English: The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Slovenian: V natisnjenem navodilu za uporabo zdravila mora biti navedeno ime in naslov izdelovalca, odgovornega za sproščanje zadevne serije.
English: Symptomatic treatment, e.g., fluid therapy, should also be provided.
Slovenian: Prav tako se uvede simptomatsko zdravljenje, npr. tekočinsko terapijo.
English: It is therefore recommended to induce vomiting, and then carry out gastric lavage (depending on the risk assessment) and monitor electrolytes.
Slovenian: Priporočljivo je sprožiti bruhanje in izprati želodec (odvisno od ocene tveganja) in kontrolirati elektrolite.
English: In case of the accidental ingestion by a dog of many Cardalis chewable tablets, there is no specific antidote or treatment.
Slovenian: V primeru, da pes nenamerno zaužije večje število Cardalis žvečljivih tablet, ni specifičnega protistrupa ali zdravljenja.
English: In the cardiovascular system, spironolactone prevents the detrimental effects of aldosterone.
Slovenian: V kardiovaskularnem sistemu spironolakton prepreči škodljive učinke aldosterona.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the bottle.
Slovenian: Zdravila za uporabo v veterinarski medicini ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na plastenki.
English: After oral administration of spironolactone to dogs, it was demonstrated that the three metabolites achieved levels of 32 to 49% of the administered dose.
Slovenian: Po peroralnem dajanju spironolaktona psom se je pokazalo, da trije metaboliti dosežejo nivoje od 32% do 49% danega odmerka.
English: Due to the antiandrogenic effect of spironolactone, it is not recommended to administer the veterinary medicinal product to growing dogs.
Slovenian: Zaradi antiandrogenega učinka spironolaktona, ni priporočljiva uporaba zdravila za uporabo v veterinarski medicini pri rastočih psih.
English: The tablets are packed bottles of 30 tablets or 90 tablets, and each bottle is presented in an outer cardboard box.
Slovenian: Tablete so pakirane v plastenki po 30 tablet ali 90 tablet, vsaka plastenka je v kartonski škatli.
English: The mean residence time of the metabolites ranges from 9 to 14 hours and they are preferentially distributed to the gastro-intestinal tract, kidney, liver and adrenal glands.
Slovenian: Čas obstanka metabolitov je od 9 do 14 ur in se preferenčno distribuirajo v gastrointestinalni trakt, ledvice, jetra in nadledvične žleze.
English: Therefore, dogs treated concomitantly with an NSAID should be closely monitored and correctly hydrated.
Slovenian: Zato je potrebno pse, sočasno zdravljene z NSAIDi, pazljivo kontrolirati in pravilno hidrirati.
English: ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
Slovenian: DODATEK I POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA
English: Steady-state conditions are reached by day 2.
Slovenian: Stabilno stanje je doseženo v 2 dneh.
English: Spironolactone may cause both induction and inhibition of cytochrome P450 enzymes and could affect the metabolism of other substances utilizing these metabolic pathways.
Slovenian: Spironolakton lahko povzroči indukcijo in inhibicijo encima citokroma P450 in lahko vpliva na presnovo drugih snovi v tej metabolični poti.
English: The systemic bioavailability of benazepril is incomplete due to incomplete absorption and first pass metabolism.
Slovenian: Sistemska biorazpoložljivost benazeprila je nepopolna zaradi nepopolne absorpcije in metabolizma prvega prehoda.
English: Do not administer in conjunction with Non Steroidal Anti-Inflammatory Drugs (NSAIDs) to dogs with renal insufficiency.
Slovenian: Ne uporabite skupaj z nesteroidnimi protivnetnimi zdravili (NSAID) pri psih z insuficienco ledvic.
English: There is no significant difference in the pharmacokinetics of benazeprilat when benazepril (as hydrochloride) is administered to fed or fasted dogs.
Slovenian: Ni pomembne razlike v farmakokinetiki benazeprila, če benazepril (kot hidroklorid) damo nahranjenemu ali teščemu psu.
English: However, aldosterone release is not fully controlled by ACE Inhibitors because Angiotensin-II is also produced by non-ACE pathways such as chymase (phenomenon known as “aldosterone breakthrough”).
Slovenian: Vendar spročanje aldosterona ni popolnoma kontrolirano z zaviralci ACE, saj angiotenzin II nastaja tudi v ne ACE poteh kot je himaza (fenomen poznan kot “preboj aldosterona”).
English: The association of spironolactone and benazepril is beneficial as both act on the renin-angiotensinaldosterone system (RAAS) but at different levels along the cascade.
Slovenian: Kombinacija spironolaktona in benazeprila je koristna, saj oba delujeta na renin-angiotenzinaldosteron sistem (RAAS), vendar na različnih nivojih kaskade.
English: Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis.
Slovenian: Ne uporabite v primeru srčnega popuščanja zaradi aortne ali pulmonarne stenoze.
English: The product should be used with caution in dogs with hepatic dysfunction because it may alter the extensive biotransformation of spironolactone in liver.
Slovenian: Pri psih z motnjami v delovanju jeter je potrebna previdna uporaba, saj lahko pride do sprememb obsežne biotransformacije spironolaktona v jetrih.
English: Therefore, to achieve a more complete inhibition of the deleterious effects of RAAS overactivity which occurs with heart failure, it is recommended to use aldosterone antagonists, such as spironolactone, concomitantly with ACE inhibitors to block specifically the activity of aldosterone (regardless of the source), through competitive antagonism on mineralocorticoid receptors.
Slovenian: Da bi dosegli bolj popolno zaviranje škodljivih učinkov prevelike aktivnosti RAAS, ki se pojavi ob srčnem popuščanju, je priporočljivo uporabiti antagoniste aldosterona, kot je spironolakton, sočasno z ACE zaviralci, da se specifično blokira učinke aldosterona (ne glede na izvor), preko kompetitivnega antagonizma na mineralokortikoidnih receptorjih.
English: The product causes a long-lasting inhibition of plasma ACE activity in dogs, with more than 95% inhibition at peak effect and significant activity (>80%) persisting 24 hours after dosing.
Slovenian: Zdravilo povzroči dolgotrajno zaviranje aktivnosti ACE v plazmi pri psih, z več kot 95% zaviranjem ob najvišjem učinku in pomembno aktivnostjo (>80%) še 24 ur po odmerku.
English: Ceva Santé Animale 10, av. de la Ballastière 33500 Libourne France
Slovenian: Ceva Santé Animale 10, av. de la Ballastière 33500 Libourne Francija
English: QUALITATIVE AND QUANTITATIVE COMPOSITION
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Zdravilne učinkovine:
English: The tablets contain beef flavouring to improve palatability, and in a field study conducted in dogs with chronic degenerative valvular disease the tablets were voluntarily and fully consumed 92% of the time when offered either with or without food.
Slovenian: Tablete vsebujejo govejo aromo za izboljšanje okusnosti in so jih v terenski študiji, narejeni pri psih s kronično degenerativno boleznijo zaklopk, psi v 92% vzeli v celoti in prostovoljno skupaj z ali brez hrane.
English: Following oral administration of 2 to 4 mg/kg, absorption increases linearly over the range.
Slovenian: Po peroralnem dajanju 2 to 4 mg/kg, se absorpcija poviša linearno.
English: Benazeprilat is a highly potent and selective inhibitor of angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I to active angiotensin II.
Slovenian: Benazeprilat je močan in selektiven zaviralec angiotenzin-konvertirajočega encima (ACE), s čimer preprečuje pretvorbo neaktivnega angiotenzina I v aktivni angiotenzin II.
English: This veterinary medicinal product does not require any special storage conditions.
Slovenian: Za to zdravilo za uporabo v veterinarski medicini ni posebnih navodil za shranjevanje.
English: Benazeprilat concentrations decline biphasically: the initial fast phase represents elimination of free drug, while the terminal phase reflects the release of benazeprilat that was bound to ACE, mainly in the tissues.
Slovenian: Koncentracije benazeprilata se znižajo v dveh fazah: začetna hitra faza predstavlja izločitev prostega zdravila, končna faza pa odraža sprostitev benazeprilata, ki je bil vezan na ACE, predvsem v tkivih.
English: The concomitant use of NSAIDs with this veterinary medicinal product may reduce its antihypertensive effect, its natriuretic effect and increase the level of serum potassium.
Slovenian: Sočasna uporaba tega zdravila za uporabo v veterinarski medicini z NSAIDi lahko zmanjša njegovo anti-hipertenzično delovanje, natriuretični učinek in poviša nivo serumskega kalija.
English: If you notice any side effects, even those not already listed in this package leaflet or you think that the medicine has not worked, please inform your veterinary surgeon.
Slovenian: Če opazite kakršne koli resne stranske učinke ali druge učinke, ki niso omenjeni v teh navodilih za uporabo, obvestite svojega veterinarja.
English: Do not use in dogs suffering from hypoadrenocorticism, hyperkalaemia or hyponatraemia.
Slovenian: Ne uporabite pri psih s hipoadrenokorticizmom, hiperkaliemijo ali hiponatriemijo.
English: Pack sizes of 30 or 90 tablets.
Slovenian: Velikost pakiranja 30 in 90 tablet.
English: In experimental models in dogs, it was shown that long term therapy with an aldosterone antagonist prevents progressive left ventricle dysfunction and attenuates left ventricle remodelling in dogs with chronic heart failure.
Slovenian: Pri eksperimentalnih vzorcih pri psih se je pokazalo, da dolgotrajno zdravljenje z antagonisti aldosterona prepreči progresivno disfunkcijo in zmanjša preoblikovanje levega prekata pri psih s kronično srčno odpovedjo.
English: Secretion of aldosterone can also be stimulated by factors other than Angiotensin-II, notably K+ increase or ACTH.
Slovenian: Sproščanje aldosterona lahko stimulirajo tudi drugi faktorji, ne le angiotenzin II, opazno povišanje K+ ali ACTH.
English: After the oral administration of radiolabelled spironolactone to the dog, 70% of the dose is recovered in faeces and 20% in the urine.
Slovenian: Po peroralnem dajanju radiološko označenega spironolaktona psom so ugotovili 70 % odmerka v blatu in 20 % v urinu.
English: CLINICAL PARTICULARS 4.1 Target species
Slovenian: 4.1 Ciljne živalske vrste
English: A slight increase in aldosterone blood levels may be observed in animals on treatment.
Slovenian: Pri zdravljenih živalih lahko opazimo rahlo povišanje aldosterona v krvi.
English: Pregnant women should take special care to avoid accidental oral exposure because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Slovenian: Nosečnice naj pazijo, da ne pride do nenamerne peroralne izpostavjenosti, saj je bilo ugotovljeno, da inhibitorji ACE vplivajo na nerojenega otroka med nosečnostjo pri ljudeh.
English: The tablets should be administered either mixed with a small amount of food offered to the dog just prior to the main meal, or with the meal itself.
Slovenian: Tablete dajemo pomešane z manjšo količino hrane ponujene psu tik pred glavnim obrokom ali pa s samim obrokom.
English: Bodyweight (kg) of dog
Slovenian: Telesna masa (kg) psa
English: The mean volumes of distribution of 7-α-thiomethyl-spironolactone and canrenone are approximately 153 litres and 177 litres respectively.
Slovenian: Volumna distribucije 7-α-tiometil-spironolaktona in kanrenona sta približno 153 in 177 litrov.
English: In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Slovenian: V primeru nenamernega zaužitja se takoj posvetujte z zdravnikom in mu pokažite navodila za uporabo ali ovojnino.
English: (spironolactonum)
Slovenian: Spironolakton (spironolactonum)
English: Clinical studies investigating the survival time demonstrated that the fixed combination increased the life expectancy in dogs with congestive heart failure with a 89% reduction in the relative risk of cardiac mortality assessed in dogs treated with spironolactone in combination with benazepril (as the hydrochloride) compared to dogs treated with benazepril (as hydrochloride) alone (mortality was classified as death or euthanasia due to heart failure).
Slovenian: Klinične študije časa preživetja so pokazale, da taka kombinacija poveča pričakovano življenjsko dobo psov s kongestivnim srčnim popuščanjem z 89% zmanjšanjem relativnega tveganja za srčno smrt, ocenjeno pri psih, zdravljenih s spironolaktonom v kombinaciji z benazeprilom (kot hidroklorid), v primerjavi s psi, zdravljenimi z benazeprilom (kot hidroklorid) samim (umrljivost je bila klasificirana kot smrt ali evtanazija zaradi odpovedi srca).
English: Spironolactone and its active metabolites (including 7-α-thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone by binding competitively to mineralocorticoid receptors located in the kidneys, heart and blood vessels.
Slovenian: Spironolakton in njegovi aktivni metaboliti (vključno z 7-α-tiometil-spironolaktonom in kanrenonom) delujejo kot specifični antagonisti aldosterona, ki svoje učinke kažejo s kompetitivno vezavo na mineralokortikoidne receptorje v ledvicah, srcu in krvnih žilah.
English: Do not use in case of hypersensitivity to Angiotensin-Converting Enzyme inhibitors (ACE inhibitors) or to any of the excipients.
Slovenian: Ne uporabite v primeru preobčutljivosti na zaviralce angiotenzin konvertirajočega encima (zaviralci ACE) ali na katerokoli pomožno snov.
English: Benazepril hydrochloride (HCl)
Slovenian: Benazeprilijev hidroklorid (HCl) (benazeprili HCl)
English: MANUFACTURER'S BATCH NUMBER
Slovenian: IZDELOVALČEVA ŠTEVILKA SERIJE Lot {številka}
English: Spironolactone decreases digoxin elimination and hence raises digoxin plasma concentration.
Slovenian: Spironolakton zmanjša izločanje digoksina in zato poviša nivo plazemskega digoksina.
English: This fixed combination product should only be used in dogs which require both active substances to be administered concomitantly at this fixed dose.
Slovenian: Zdravilo za uporabo v veterinarski medicini s to kombinacijo naj se uporablja samo pri psih, ki potrebujejo obe zdravilni učinkovini sočasno v določenem odmerku.
English: Spironolactone is rapidly and completely metabolised by the liver into its active metabolites, 7αthiomethyl-spironolactone and canrenone, which are the primary metabolites in the dog.
Slovenian: Spironolakton se hitro in v celoti metabolizira v jetrih v aktivna metabolita, 7-α-tiometil-spironolakton in kanrenon, ki sta primarna metabolita pri psih.
English: PACKAGE SIZE
Slovenian: Velikost pakiranja
English: Therefore, the product should be used with caution with other veterinary medicinal products which induce, inhibit, or which are metabolised by these enzymes.
Slovenian: Zato naj se zdravilo za uporabo v veterinarski medicini previdno uporablja skupaj z drugimi zdravili za uporabo v veterinarski medicini, ki inducirajo, zavirajo ali se presnavljajo s temi encimi.
English: ANNEX III LABELLING AND PACKAGE LEAFLET
Slovenian: DODATEK III OZNAČEVANJE IN NAVODILO ZA UPORABO
English: The tablets should be administered with food, either mixed with a small amount of food offered to the dog just prior to the main meal, or with the meal itself.
Slovenian: Tablete dajemo skupaj s hrano, pomešane z manjšo količino hrane, ponujene psu tik pred glavnim obrokom ali pa skupaj s samim obrokom.
English: Shelf-life after first opening the bottle: 6 months.
Slovenian: Rok uporabnosti po prvem odprtju stične ovojnine: 6 mesecev.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER AND OF THE MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE, IF DIFFERENT
Slovenian: IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM TER IMETNIKA DOVOLJENJA ZA IZDELAVO ZDRAVILA, ODGOVORNEGA ZA SPROSTITEV SERIJE V EGP, ČE STA RAZLIČNA
English: Therefore, it blocks effects mediated by angiotensin II, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney.
Slovenian: Zato zavira učinke angiotenzina II, ki vključujejo vazoknstrikcijo arterij in ven, zadrževanje natrija in vode v ledvicah.
English: In the kidney, spironolactone inhibits the aldosterone-induced sodium retention leading to increase in sodium, and subsequently water excretion, and potassium retention.
Slovenian: V ledvicah spironolakton inhibira aldosteronsko inducirano zadrževanje natrija, kar vodi k zvečanemu izločanju natrija in posledično izločanju vode in zadrževanju kalija.
English: The resulting reduction in extracellular volume decreases the cardiac preload and left atrial pressure.
Slovenian: Posledično zmanjšanje ekstracelularnega volumna zmanjša pritok v srce in pritisk v levem atriju.
English: The administration of deoxycorticosterone with the product may lead to a moderate reduction of the natriuretic effects (reduction of urinary sodium excretion) of spironolactone.
Slovenian: Dajanje deoksikortikosterona skupaj s tem zdravilom za uporabo v veterinarski medicini lahko vodi do zmernega zmanjšanja natriuretičnega učinka (zmanjšanje izločanja urinskega natrija) spironolaktona.
English: Benazepril and benazeprilat are rapidly distributed, mainly in liver and kidney.
Slovenian: Benazepril in benazeprilat se hitro distribuirata, v glavnem v jetra in ledvice.
English: A dose related but moderate compensatory physiological hypertrophy of zona glomerulosa of the adrenal glands was also observed at doses of 3 times and greater of the recommended dose.
Slovenian: Prav tako je bila opažena od odmerka odvisna, a zmerna kompenzatorna fiziološka hipertrofija cone glomeruloze nadledvične žleze, pri 3 kratnem in večjem odmerku od priporočenega odmerka.
English: After oral administration of benazepril hydrochloride, peak levels of benazepril are attained rapidly and decline quickly as the drug is partially metabolized by liver enzymes to benazeprilat.
Slovenian: Po peroralnem zaužitju benazeprilijevega hidroklorida so najvišje vrednosti benazeprila dosežene hitro in se hitro znižajo, ko jetrni encimi zdravilo delno pretvorijo v benazeprilat.
English: For the treatment of congestive heart failure caused by chronic degenerative valvular disease in dogs (with diuretic support, as appropriate).
Slovenian: Zdravljenje kongestivnega srčnega popuščanja zaradi kronične degenerativne bolezni zaklopk pri psih (z diuretično podporo, če je to potrebno).
English: THE WORDS “FOR ANIMAL TREATMENT ONLY”
Slovenian: BESEDILO “SAMO ZA ŽIVALI” Samo za živali.
English: A. MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALEC ODGOVOREN ZA SPROSTITEV SERIJE
English: The clearance of benazeprilat is not affected in dogs with impaired renal function and therefore no adjustment of benazepril dose is required in cases of renal insufficiency
Slovenian: Izločanje benazeprilata pri psih z okvaro ledvic ni ovirano, zato v primeru okvare ledvic ni potrebno prilagajati odmerka benazeprila.
English: The plasma clearances of canrenone and 7-αthiomethyl-spironolactone are 1.5 l/h/kg bw and 0.9 l/h/kg bw respectively.
Slovenian: Plazemski klirens kanrenona in 7-α-tiometilspironolaktona je 1.5 l/h/kg in 0.9 l/h/kg.
English: The pharmacokinetics of spironolactone are based on its metabolites, as the parent compound is unstable at assay.
Slovenian: Farmakokinetika spironolaktona temelji na njegovih metabolitih, ker je sam spironolakton nestabilen.
English: Benazepril and benazeprilat are extensively bound to plasma proteins, and in tissues are found mainly in the liver and kidney.
Slovenian: Benazepril in benazeprilat se v veliki meri vežeta na proteine v plazmi, v tkivih pa se nahajata predvsem v jetrih in ledvicah.
English: Benazepril, by preventing the formation of Angiotensin-II, inhibits the detrimental effects of vasoconstriction and stimulation of aldosterone release.
Slovenian: Benazepril deluje tako, da preprečuje nastajanje angiotenzina II, zavira škodljive učinke vazokonstrikcije in stimulira sproščaje aldosterona.
English: However, regular monitoring of renal function and serum potassium levels is recommended in dogs with renal impairment, as they may have an increased risk of hyperkalaemia during treatment with this product.
Slovenian: Priporoča se redna kontrola delovanja ledvic in nivoja serumskega kalija pri psih z ledvično okvaro, saj je pri njih povečana verjetnost pojava hiperkaliemije med zdravljenjem s tem zdravilom za uporabo v veterinarski medicini.
English: EU/2/12/142/001 (1 x 30 tablets 2.5 mg/20 mg) EU/2/12/142/002 (1 x 90 tablets 2.5 mg/20 mg) EU/2/12/142/003 (1 x 30 tablets 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tablets 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tablets 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tablets 10 mg/80 mg)
Slovenian: EU/2/12/142/001 (1 x 30 tablet 2.5 mg/20 mg) EU/2/12/142/002 (1 x 90 tablet 2.5 mg/20 mg) EU/2/12/142/003 (1 x 30 tablet 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tablet 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tablet 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tablet 10 mg/80 mg)
English: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje neporabljenega zdravila ali odpadnih snovi Vsako neporabljeno zdravilo za uporabo v veterinarski medicini ali odpadne snovi, ki nastanejo iz teh zdravil, je treba odstraniti v skladu z lokalnimi predpisi.
English: As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril (hydrochloride) and spironolactone.
Slovenian: Ker je terapevtski indeks za digoksin zelo ozek, je priporočljivo pazljivo spremljanje stanja živali, ki prejemajo digoksin in kombinacijo benazeprila (hidroklorid) in spironolakona.
English: As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril hydrochloride and spironolactone.
Slovenian: Ker je terapevtski indeks za digoksin zelo ozek, je priporočljivo pazljivo spremljanje stanja živali, ki prejemajo digoksin in kombinacijo spironolakona in benazeprilijevega hidroklorida.
English: EXP {month/year}
Slovenian: DATUM IZTEKA ROKA UPORABNOSTI ZDRAVILA EXP {mesec/leto}
English: Furosemide has been used together with this combination of benazepril hydrochloride and spironolactone in dogs with heart failure without any clinical evidence of adverse interactions.
Slovenian: Furosemid je bil uporabljen v kombinaciji s benazeprilijevim hidrokloridom in spironolaktonom pri psih s srčnim popuščanjem brez pojava kliničnih znakov neželenega medsebojnega delovanja.
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system, ACE inhibitors, combinations.
Slovenian: Farmakoterapevtska skupina: zaviralci ACE, kombinacija.
English: Spironolactone is mainly excreted via its metabolites.
Slovenian: Spironolakton se največ izloča v obliki metabolitov.