FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients with severe hepatic impairment must be carefully monitored for drug toxicity (see section 4.8).
Croatian: Bolesnike s teškim oštećenjem jetre mora se pomno nadzirati kako bi se uočila eventualna toksičnost lijeka (vidjeti dio 4.8).
English: • Alfentanil and fentanyl and other short acting opiates such as sufentanil (painkillers used for surgical procedures)
Croatian: • alfentanil, fentanil i ostale opijate kratkog djelovanja, kao što je sufentanil (lijekovi protiv bolova koji se koriste za vrijeme kirurških zahvata)
English: The excretion of voriconazole into breast milk has not been investigated.
Croatian: Nije se ispitivalo izlučivanje vorikonazola u majčino mlijeko.
English: Volume of Voriconazole Hikma Concentrate (10 mg/ml) required for:
Croatian: Volumen koncentrata lijeka Vorikonazol Hikma (10 mg/ml) potreban za:
English: Voriconazole is haemodialysed with a clearance of 121 ml/min.
Croatian: Vorikonazol se odstranjuje hemodijalizom klirensom od 121 ml/min.
English: A study has been conducted in healthy volunteers which examined the effect on QTc interval of single doses of voriconazole up to 4 times the usual daily dose.
Croatian: U kliničkom ispitivanju provedenom u zdravih dobrovoljaca ispitivao se učinak vorikonazola na QTc-interval uz primjenu pojedinačnih doza i do 4 puta većih od uobičajene dnevne doze.
English: All occurred in paediatric patients, who received up to five times the recommended intravenous dose of voriconazole.
Croatian: Sva 3 slučaja zabilježena su u djece koja su dobila do 5 puta veću intravensku dozu vorikonazola od preporučene.
English: When the recommended intravenous or oral loading dose regimens are administered, plasma concentrations close to steady state are achieved within the first 24 hours of dosing.
Croatian: Kada se primjenjuju preporučene intravenske ili peroralne udarne doze, koncentracije lijeka u plazmi približne vrijednostima u stanju dinamičke ravnoteže postižu se tijekom prva 24 sata nakon primjene.
English: The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of voriconazole.
Croatian: Akumulacija 14-alfa-metil sterola povezana je s posljedičnim nestajanjem ergosterola iz gljivične stanične membrane i može biti odgovorna za antifungalno djelovanje vorikonazola.
English: Careful monitoring for any occurrence of drug toxicity and/or lack of efficacy, and dose adjustment may be needed.
Croatian: Možda će biti potrebno pomno pratiti bolesnika zbog moguće toksičnosti i/ili nedovoljne djelotvornosti lijeka te eventualno prilagoditi dozu.
English: Musculoskelet al and connective tissue disorders back pain arthritis periostitis*
Croatian: Poremećaji mišićnokoštanog sustava i vezivnog tkiva bol u leđima artritis periostitis*
English: • Treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei).
Croatian: • liječenje teških invazivnih infekcija uzrokovanih kandidom (uključujući C. krusei) rezistentnih na flukonazol,
English: The pharmacokinetics of voriconazole are non-linear due to saturation of its metabolism.
Croatian: Farmakokinetika vorikonazola je nelinearna zbog zasićenja njegova metabolizma.
English: • Pimozide (used for treating mental illness)
Croatian: • pimozid (koristi se za liječenje duševnih bolesti)
English: The predicted total exposure in children following an oral maintenance dose of 9 mg/kg (maximum of 350 mg) twice daily was comparable to that in adults following 200 mg oral twice daily.
Croatian: Predviđena ukupna izloženost u djece nakon primjene peroralne doze održavanja od 9 mg/kg (najviše 350 mg) dvaput na dan bila je usporediva s onom uodraslih nakon primjene doze od 200 mg dvaput na dan.
English: Post-marketing data suggest there might be a higher occurrence of skin reactions (especially erythema) in the paediatric population compared to adults.
Croatian: Podaci nakon stavljanja lijeka u promet upućuju na to da je u pedijatrijskoj populaciji moguća veća pojavnost kožnih reakcija (poglavito eritema) u odnosu na odrasle.
English: In patients with moderate to severe renal dysfunction (serum creatinine levels >2.5 mg /dl), accumulation of the intravenous vehicle, SBECD, occurs (see sections 4.2 and 4.4).
Croatian: U bolesnika s umjerenom do teškom disfunkcijom bubrega (razine kreatinina u serumu > 2,5 mg/dl) dolazi do kumulacije intravenskog vehikuluma, SBECD-a (vidjeti dijelove 4.2 i 4.4).
English: In a secondary analysis, which utilised DRC assessments at the latest evaluable time point (EOT, or 2, 6, or 12 weeks after EOT) voriconazole and the regimen of amphotericin B followed by fluconazole had successful response rates of 65 % and 71 %, respectively.
Croatian: U sekundarnoj analizi u kojoj su korištene ocjene DRC-a u posljednjoj ocjenjivoj vremenskoj točki (završetak liječenja, odnosno 2, 6 ili 12 tjedana po završetku liječenja), stopa pozitivnog odgovora u skupini liječenoj vorikonazolom iznosila je 65%, a u skupini liječenoj amfotericinom B pa potom flukonazolom 71%.
English: As the half-life of alfentanil is prolonged in a 4-fold manner when alfentanil is coadministered with voriconazole and in an independent published study, concomitant use of voriconazole with fentanyl resulted in an increase in the mean AUC 0-∞ of fentanyl, frequent monitoring for opiate-associated adverse reactions (including a longer respiratory monitoring period) may be necessary.
Croatian: Budući da je poluvijek alfentanila četverostruko produljen pri istodobnoj primjeni alfentanila s vorikonazolom, a u neovisnom je objavljenom ispitivanju istodobna primjena vorikonazola s fentanilom rezultirala povećanjem prosječnog AUC 0-∞ fentanila, možda će biti potrebne česte kontrole zbog mogućih nuspojava povezanih s opijatima (uključujući dulji nadzor respiratorne funkcije).
English: Voriconazole should be administered primarily to patients with progressive, possibly life-threatening infections.
Croatian: Vorikonazol treba primjenjivati prvenstveno u bolesnika s progresivnim, moguće i po život opasnim infekcijama.
English: However, the in vitro activity of voriconazole against Candida species is not uniform.
Croatian: Međutim, djelovanje vorikonazola in vitro na vrste iz roda Candida nije ujednačeno.
English: Voriconazole Hikma must not be used during pregnancy unless the benefit to the mother clearly outweighs the potential risk to the foetus.
Croatian: Hikma se ne smije primjenjivati u trudnoći osim ako korist liječenja za majku jasno ne nadilazi mogući rizik za plod.
English: Hospira UK Limited Queensway Royal Leamington Spa Warwickshire CV31 3RW UK
Croatian: Royal Leamington Spa Warwickshire CV31 3RW Ujedinjeno Kraljevstvo
English: The ERG measures electrical currents in the retina.
Croatian: ERG mjeri električne struje u mrežnici.
English: Multiple intravenous doses of 3, 4, 6, 7 and 8 mg/kg twice daily and multiple oral doses (using the powder for oral suspension) of 4 mg/kg, 6 mg/kg, and 200 mg twice daily were evaluated in 3 paediatric pharmacokinetic studies.
Croatian: Primjena višekratnih intravenskih doza od 3, 4, 6, 7 i 8 mg/kg dvaput na dan te višekratnih peroralnih doza (koristeći prašak za oralnu suspenziju) od 4 mg/kg i 6 mg/kg te 200 mg dvaput na dan ocijenjena je u 3 pedijatrijska farmakokinetička ispitivanja.
English: This represents a heterogeneous population, containing patients with haematological malignancy, HIV infected patients with oesophageal candidiasis and refractory fungal infections, non-neutropenic patients with candidaemia or aspergillosis and healthy volunteers.
Croatian: Riječ je o heterogenoj populaciji sastavljenoj od bolesnika s malignim hematološkim bolestima, bolesnika s kandidijazom jednjaka i refraktornim gljivičnim infekcijama zaraženih virusom HIV-a, bolesnika bez neutropenije s kandidemijom ili aspergilozom te zdravih dobrovoljaca.
English: This will be given to you by intravenous infusion (into a vein) at a maximum rate of 3 mg/kg per hour over 1 to 3 hours.
Croatian: Tako pripremljeni lijek ćete primati intravenskom infuzijom (u venu) tijekom razdoblja od 1 do 3 sata, brzinom od najviše 3 mg/kg na sat.
English: After IV voriconazole therapy, the median duration of oral voriconazole therapy was 76 days (range 2-232 days).
Croatian: Nakon intravenskog liječenja medijan trajanja peroralne primjene vorikonazola je iznosio 76 dana (raspon 2-232 dana).
English: In addition voriconazole shows in vitro fungicidal activity against emerging fungal pathogens, including those such as Scedosporium or Fusarium which have limited susceptibility to existing antifungal agents.
Croatian: Nadalje, vorikonazol in vitro djeluje fungicidno na nove gljivične patogene, uključujući i rodove Scedosporium ili Fusarium, čija je osjetljivost na postojeće antimikotike ograničena.
English: The absorption of voriconazole is not affected by changes in gastric pH.
Croatian: Na apsorpciju vorikonazola ne utječu promjene želučanog pH.
English: • Ergot alkaloids (e.g., ergotamine, dihydroergotamine; used for migraine)
Croatian: • ergot alkaloidi (npr. ergotamin, dihidroergotamin; koriste se za liječenje migrene)
English: Voriconazole administration induced no impairment of male or female fertility in rats at exposures similar to those obtained in humans at therapeutic doses.
Croatian: Primjena vorikonazola nije proizvela poremećaje plodnosti mužjaka i ženski štakora pri izloženosti sličnoj onoj koja se postiže u ljudi primjenom terapijskih doza.
English: In clinical trials, there have been cases of serious hepatic reactions during treatment with voriconazole (including clinical hepatitis, cholestasis and fulminant hepatic failure, including fatalities).
Croatian: U kliničkim ispitivanjima za vrijeme liječenja vorikonazolom zabilježeni su slučajevi ozbiljnih jetrenih reakcija (uključujući klinički hepatitis, kolestazu i fulminantno zatajenje jetre, neke sa smrtnim ishodom).
English: The required volume of the reconstituted concentrate is then added to a recommended compatible infusion solution listed below to obtain a final Voriconazole Hikma solution containing 0.5 to 5 mg/ml of voriconazole.
Croatian: Zatim se potreban volumen pripremljenog koncentrata dodaje u jednu od preporučenih kompatibilnih infuzijskih otopina navedenih u nastavku, kako bi se dobila konačna otopina lijeka Vorikonazol Hikma koja sadrži 0,5 - 5 mg/ml vorikonazola.
English: Rifabutin or phenytoin may be co-administered with voriconazole if the maintenance dose of voriconazole is increased to 5 mg/kg intravenously twice daily, see sections 4.4 and 4.5.
Croatian: Rifabutin ili fenitoin se smije istodobno primijeniti s vorikonazolom ako se doza održavanja vorikonazola poveća na 5 mg/kg intravenski dvaput na dan, vidjeti dijelove 4.4 i 4.5.
English: • Vinca alkaloids (e.g., vincristine and vinblastine) (used in treating cancer)
Croatian: • vinka alkaloide (npr. vinkristin i vinblastin) (koriste se za liječenje raka)
English: Therapy could then be switched to the oral formulation at a dose of 200 mg every 12 hours.
Croatian: Nakon toga se moglo prijeći na peroralni oblik lijeka u dozi od 200 mg svakih 12 sati.
English: Fentanyl (5 μg/kg single dose)
Croatian: Fentanil (jedna doza od 5 μg/kg)
English: Rifabutin (Potent CYP450 inducer)
Croatian: Rifabutin (potentni induktor CYP450)
English: If patient is unable to tolerate intravenous treatment at 4 mg/kg twice daily, reduce the dose to 3 mg/kg twice daily.
Croatian: Ako bolesnik ne podnosi intravensko liječenje dozom od 4 mg/kg dvaput na dan, treba smanjiti dozu na 3 mg/kg dvaput na dan.
English: Side effects with frequency not known: • Freckles and pigmented spots
Croatian: Nuspojave s nepoznatom učestalošću: - pjege i pigmentirane mrlje
English: Maintenance Dose (after first 24 hours)
Croatian: Doza održavanja (nakon prva 24 sata)
English: • Phenobarbital (used for severe insomnia and seizures)
Croatian: • fenobarbital (koristi se kod teške nesanice i epileptičkih napadaja)
English: For patients less than 40 kg the oral dose may be increased to 150 mg twice daily.
Croatian: U bolesnika tjelesne težine manje od 40 kg peroralna doza se može povećati na 150 mg dvaput na dan.
English: Ciclosporin (in stable renal transplant recipients receiving chronic ciclosporin therapy)
Croatian: Ciklosporin (u primatelja presatka bubrega stabilnog stanja koji se dugotrajno liječe ciklosporinom)
English: Mycophenolic acid (1 g single dose) [UDP-glucuronyl transferase substrate]
Croatian: Mikofenolna kiselina (jedna doza od 1 g) [supstrat UDP-glukuronil transferaze]
English: • Concomitant medicinal product that is known to prolong QTc interval.
Croatian: • istodobna primjena lijekova koji produljuju QTc-interval.
English: There have been reports of skin cancer in patients treated with voriconazole for long periods of time
Croatian: Prijavljen je rak kože u bolesnika koji su liječeni vorikonazolom kroz duži vremenski period.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each vial contains 200 mg of voriconazole.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Jedna bočica sadrži 200 mg vorikonazola.
English: Voriconazole should be administered with caution to patients with potentially proarrhythmic conditions, such as
Croatian: Vorikonazol treba primjenjivati uz oprez u bolesnika s potencijalno proaritmijskim stanjima, kao što su:
English: 30 ml clear Type I glass vial closed with a chlorobutyl rubber stopper and sealed with an aluminium flip off seal with a red plastic matte top button.
Croatian: Staklena bočica od 30 ml (prozirno staklo tipa I) s klorobutilnim gumenim čepom i zaštitnom aluminijskom kapicom s mat crvenim plastičnim zatvaračem.
English: Respiratory, thoracic and mediastinal disorders respiratory distress9
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja respiratorni distres9
English: There is a small chance that skin cancer could develop with long term use of Voriconazole Hikma.
Croatian: Postoji mala šansa od razvoja karcinoma kože uz dugoročnu primjenu lijeka Vorikonazol Hikma.
English: Co-administration of standard doses of voriconazole with efavirenz doses of 400 mg once daily or higher is contraindicated, because efavirenz significantly decreases plasma voriconazole concentrations in healthy subjects at thesedoses.
Croatian: Istodobna primjena standardne doze vorikonazola s dozama efavirenza od 400 mg jedanput na dan ili više je kontraindicirana, jer efavirenz u toj dozi značajno smanjuje koncentraciju vorikonazola u plazmi zdravih ispitanika.
English: Diclofenac (50 mg single dose)
Croatian: Diklofenak (jedna doza od 50 mg)
English: In an oral multiple dose study, Cmax and AUCτ for healthy young females were 83 % and 113 % higher, respectively, than in healthy young males (18-45 years).
Croatian: U ispitivanju s višekratnom primjenom peroralne doze lijeka Cmax i AUCτ je u zdravih mladih žena bio 83%, odnosno 113% veći nego u zdravih mladih muškaraca (18-45 godina).
English: The compatibility of Voriconazole Hikma with diluents other than listed above (or listed below under ‘Incompatibilities') is unknown.
Croatian: Nije poznata kompatibilnost lijeka Vorikonazol Hikma s otopinama za razrjeđivanje, osim prethodno navedenih (ili onih navedenih u dijelu „Inkompatibilnosti”).
English: Eye disorders visual impairment6
Croatian: Poremećaji oka oštećenje vida6
English: Fertility In an animal study, no impairment of fertility was demonstrated in male and female rats (see section 5.3).
Croatian: U istraživanjima na životinjama nisu zabilježeni štetni učinci na plodnost mužjaka i ženki štakora (vidjeti dio
English: Other medicines and Voriconazole Hikma
Croatian: Drugi lijekovi i Vorikonazol Hikma
English: Prior to use this medicine does not require any special temperature storage conditions.
Croatian: Prije primjene ovaj lijek ne zahtijeva posebne temperaturne uvjete čuvanja.
English: If any side effects occur, most are likely to be minor and temporary.
Croatian: Pojave li se nuspojave, one će u većini slučajeva biti blage i prolazne.
English: Rare ≥ 1/10,000 to <
Croatian: Manje često ≥ 1/1000 i <
English: In vitro activity against clinical isolates has been observed for Acremonium spp., Alternaria spp., Bipolaris spp., Cladophialophora spp., Histoplasma capsulatum, with most strains being inhibited by concentrations of voriconazole in the range 0.05 to 2 μg/ml.
Croatian: Zabilježena je aktivnost in vitro protiv kliničkih izolata vrsta iz rodova Acremonium, Alternaria, Bipolaris i Cladophialophora te Histoplasma capsulatum, gdje je najveći broj sojeva bio inhibiran pri koncentracijama vorikonazola u rasponu od 0,05 do 2 µg/ml.
English: Serum creatinine levels should be closely monitored in these patients and, if increases occur, consideration should be given to changing to oral voriconazole therapy (see section 5.2).
Croatian: Treba pažljivo nadzirati razine kreatinina u serumu tih bolesnika te, porastu li, razmisliti o prelasku na peroralnu primjenu vorikonazola (vidjeti dio 5.2).
English: Itraconazole N=241
Croatian: Itrakonazol N=241
English: • Fluconazole (used for treating fungal infections)
Croatian: • flukonazol (koristi se za liječenje gljivičnih infekcija)
English: Children aged 2 to less than 12 years and teenagers aged 12 to 14 years weighing less than 50 kg
Croatian: Intravenska primjena Djeca u dobi od 2 do nepunih 12 godina i adolescenti od 12 do 14 godina koji imaju manje od 50 kg
English: Increased tacrolimus levels have been associated with nephrotoxicity.
Croatian: Povišene razine takrolimusa povezuju se s nefrotoksičnošću.
English: Patients must avoid potentially hazardous tasks, such as driving or operating machinery while experiencing these symptoms.
Croatian: Dok traju navedeni simptomi, bolesnici moraju izbjegavati potencijalno opasne radnje, kao što je upravljanje vozilima ili rukovanje strojevima.
English: Phenytoin (CYP2C9 substrate and potent CYP450 inducer) Careful monitoring of phenytoin levels is recommended when phenytoin is co-administered with voriconazole.
Croatian: Fenitoin (supstrat CYP2C9 i snažan induktor CYP450) Preporučuje se pažljivo praćenje koncentracije fenitoina kada ga se primjenjuje istodobno s vorikonazolom.
English: Tell your doctor if you are taking the following medicine, as treatment with Voriconazole Hikma at the same time should be avoided if possible:
Croatian: Obavijestite svog liječnika ako uzimate sljedeći lijek, jer treba izbjegavati istodobno liječenje lijekom Vorikonazol Hikma ako je to moguće:
English: Voriconazole Hikma must not be used during pregnancy, unless indicated by your doctor.
Croatian: Hikma se ne smije primjenjivati tijekom trudnoće osim ako Vaš liječnik nije tako odlučio.
English: Rifabutin Cmax ↑ 195% Rifabutin AUCτ ↑ 331% Compared to voriconazole 200 mg BID,
Croatian: Rifabutin Cmax ↑195% Rifabutin AUCτ ↑ 331% U usporedbi s dozom vorikonazola od 200 mg BID,
English: • Non-steroidal anti-inflammatory drugs (e.g., ibuprofen, diclofenac) (used for treating pain and inflammation)
Croatian: • nesteroidne protuupalne lijekove (npr. ibuprofen, diklofenak) (koriste se za liječenje boli i upale)
English: Visual impairments may be associated with higher plasma concentrations and/or doses.
Croatian: Moguće je da su povezana s višim koncentracijama lijeka u plazmi i/ili višim dozama.
English: • Rifabutin (used for treating tuberculosis).
Croatian: • rifabutin (koristi se za liječenje tuberkuloze).
English: • Quinidine (used for irregular heart beat)
Croatian: • kinidin (koristi se za liječenje nepravilnih otkucaja srca)
English: Voriconazole Hikma requires reconstitution and dilution (see section 6.6) prior to administration as an intravenous infusion.
Croatian: Hikma se mora pripremiti i razrijediti (vidjeti dio 6.6) prije primjene intravenskom infuzijom.
English: Voriconazole is a triazole antifungal agent.
Croatian: Vorikonazol je triazolski antimikotik.
English: Sodium Chloride 9 mg/ml (0.9%) Solution for Injection Compound Sodium Lactate Intravenous Infusion 5% Glucose and Lactated Ringer's Intravenous Infusion 5% Glucose and 0.45% Sodium Chloride Intravenous Infusion 5% Glucose Intravenous Infusion 5% Glucose in 20 mEq Potassium Chloride Intravenous Infusion 0.45% Sodium Chloride Intravenous Infusion 5% Glucose and 0.9% Sodium Chloride Intravenous Infusion
Croatian: otopinom natrijevog klorida za injekciju od 9 mg/ml (0,9%) složenom otopinom natrijevog laktata za intravensku infuziju otopinom 5% glukoze i Ringerove otopine s laktatom za intravensku infuziju otopinom 5% glukoze i 0,45% natrijevog klorida za intravensku infuziju otopinom 5% glukoze za intravensku infuziju otopinom 5% glukoze u otopini kalijevog klorida od 20 mEq za intravensku infuziju otopinom 0,45% natrijevog klorida za intravensku infuziju otopinom 5% glukoze i 0,9% natrijevog klorida za intravensku infuziju
English: Patients receiving voriconazole must be carefully monitored for hepatic toxicity.
Croatian: U bolesnika koji uzimaju vorikonazol mora se pažljivo pratiti hepatotoksičnost.
English: Children and adolescents Voriconazole Hikma should not be given to children younger than 2 years of age.
Croatian: Hikma se ne smije davati djeci mlađoj od 2 godine.
English: Voriconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems.
Croatian: Vorikonazol je pokazao veću selektivnost za enzime gljivičnog citokroma P450 nego za različite enzimske sustave citokroma P450 u sisavaca.
English: Voriconazole is eliminated via hepatic metabolism with less than 2 % of the dose excreted unchanged in the urine.
Croatian: Vorikonazol se eliminira putem jetrenog metabolizma, a svega 2% doze izlučuje se mokraćom u nepromijenjenom obliku.
English: acute respiratory distress syndrome, pulmonary oedema
Croatian: akutni respiratorni sindrom, edem pluća
English: The majority of rashes were of mild to moderate severity.
Croatian: Nuspojave su općenito bile blage do umjereno teške.
English: Squamous cell carcinoma of the skin (SCC) has been reported in relation with long-term VORICONAZOLE HIKMA treatment.
Croatian: Karcinom skvamoznih stanica kože (SCC) prijavljen je u vezi s dugotrajnim liječenjem lijekom VORIKONAZOL HIKMA.
English: Digoxin (0.25 mg QD) [P-gp substrate]
Croatian: Digoksin (0,25 mg QD) [supstrat P-glikoproteina]
English: The studies included cerebral, sinus, pulmonary and disseminated aspergillosis in patients with bone marrow and solid organ transplants, haematological malignancies, cancer and AIDS.
Croatian: U ispitivanja su bili uključeni bolesnici s aspergilozom mozga, sinusa, pluća ili diseminiranom aspergilozom koji su imali transplantaciju koštane srži ili solidnih organa, ili su bolovali od hematoloških malignih bolesti, karcinoma i AIDS-a.
English: Immune system disorders hypersensitivity anaphylactoid reaction
Croatian: Poremećaji imunološkog sustava preosjetljivost anafilaktoidna reakcija
English: In vitro studies show that voriconazole may inhibit the metabolism of HIV protease inhibitors and the metabolism of voriconazole may also be inhibited by HIV protease
Croatian: Ispitivanja in vitro pokazuju da vorikonazol može inhibirati metabolizam inhibitora HIV proteaze, ali i da inhibitori HIV proteaze također mogu inhibirati metabolizam vorikonazola.
English: Cerebrospinal fluid samples from eight patients in a compassionate programme showed detectable voriconazole concentrations in all patients.
Croatian: U svim uzorcima cerebrospinalnog likvora osmero bolesnika iz programa milosrdne primjene lijeka utvrđene su mjerljive koncentracije vorikonazola.
English: For administration, the required volume of the reconstituted concentrate is added to a recommended compatible infusion solution (detailed below) to obtain a final voriconazole solution containing 0.5-5 mg/ml.
Croatian: Prije primjene se potreban volumen pripremljenog koncentrata dodaje u jednu od preporučenih kompatibilnih infuzijskih otopina (detaljnije su navedene u nastavku), kako bi se dobila konačna otopina vorikonazola koja sadrži 0,5 - 5 mg/ml.