FrancophonIA/ELRC3.0 huggingface dataset:
English: For these sedatives/hypnotics, dose reduction may be necessary and concentration monitoring is recommended.
Slovenian: Pri teh sedativih/hipnotikih bo morebiti potrebno zmanjšanje odmerka, priporoča se tudi spremljanje koncentracij.
English: Do not chew, crush or split the tablet.
Slovenian: Tablete ne žvečite, drobite in ne delite.
English: You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
Slovenian: Virus HIV lahko še vedno prenesete tudi na druge, ko jemljete to zdravilo, čeprav učinkovito protiretrovirusno zdravljenje zmanjša to tveganje.
English: Cobicistat and atazanavir should only be used during pregnancy if the potential benefit justifies the potential risk to the foetus and mother.
Slovenian: Kobicistat in atazanavir se lahko med nosečnostjo uporabljata le, če možne koristi upravičijo možna tveganja za plod in mater.
English: If you do miss a dose and notice:
Slovenian: Če ste pozabili vzeti odmerek in to opazite:
English: Cobicistat is not expected to induce CYP3A4 or P-gp (MDR1).
Slovenian: Ne pričakuje se, da bi kobicistat induciral CYP3A4 ali P-gp (MDR1).
English: Tybost must be taken orally, once daily with food.
Slovenian: Zdravilo Tybost se jemlje peroralno enkrat na dan s hrano.
English: If you are a woman with HIV it is recommended that you do not breast-feed to avoid passing the virus to the baby through your breast milk.
Slovenian: Če ste ženska, okužena z virusom HIV, je priporočljivo, da ne dojite, da s tem preprečite prenos virusa preko mleka na dojenčka.
English: As cobicistat is highly bound to plasma proteins, it is unlikely that it will be significantly removed by hemodialysis or peritoneal dialysis.
Slovenian: Ker se kobicistat močno veže na plazemske proteine, ni verjetno, da bi ga hemodializa ali peritonealna dializa odstranila v pomembni meri.
English: The lowest dose of digoxin should initially be prescribed.
Slovenian: Uvodoma je treba predpisati najmanjši odmerek digoksina.
English: Pharmacokinetics of cobicistat have not been fully evaluated in the elderly (65 years of age and older).
Slovenian: Farmakokinetičnih lastnosti kobicistata pri starejših (starih nad 65 let) niso v celoti ovrednotili.
English: Tybost does not directly treat your HIV, but boosts the levels of atazanavir and darunavir in the blood.
Slovenian: Zdravilo Tybost ne zdravi neposredno okužbe s HIV, temveč okrepi ravni atazanavirja in darunavirja v krvi.
English: These medicines are used to treat allergies, asthma, inflammatory bowel diseases, inflammatory conditions of the eyes, joints and muscles and other inflammatory conditions.
Slovenian: Ta zdravila se uporabljajo za zdravljenje alergij, astme, vnetnih črevesnih bolezni, vnetnih bolezni oči, sklepov in mišic ter drugih vnetnih bolezni.
English: • clarithromycin and rifabutin, medicines used to treat bacterial infections including tuberculosis
Slovenian: • klaritromicin in rifabutin; zdravili, ki se uporabljata za zdravljenje bakterijskih okužb, vključno s tuberkulozo
English: This increase is not considered to be clinically relevant and does not necessitate dose adjustment of tenofovir disoproxil.
Slovenian: To zvišanje ne velja kot klinično pomembno in zaradi njega ni treba prilagoditi odmerka dizoproksiltenofovirata.
English: This effect on serum creatinine, leading to a decrease in the estimated creatine clearance, should be taken into consideration when cobicistat is administered to patients in whom the estimated creatinine clearance is used to guide aspects of their clinical management, including adjusting doses of co-administered medicinal products.
Slovenian: Ta učinek na serumski kreatinin, ki povzroči zmanjšanje ocenjenega očistka kreatinina, je treba upoštevati pri dajanju kobicistata bolnikom, pri katerih se ocenjeni očistek kreatinina uporablja kot smernica za vodenje njihove klinične obravnave, vključno s prilagajanjem sočasno odmerjanih zdravil.
English: insomnia, abnormal dreams
Slovenian: nespečnost, nenormalne sanje
English: The rates of study drug discontinuation due to bilirubin-related adverse events were low and similar in both groups (4.9% in the cobicistat-boosted group and 4.0% in the ritonavir-boosted group).
Slovenian: Stopnje prekinitve zdravljenja s študijskim zdravilom zaradi neželenih učinkov, povezanih z bilirubinom, so bile nizke in podobne za obe skupini (4,9 % v skupini zdravila, okrepljenega s kobicistatom, in 4,0 % v skupini zdravila, okrepljenega z ritonavirjem).
English: If you forget to take Tybost
Slovenian: Če ste pozabili vzeti zdravilo Tybost
English: There are some medicines that should never be taken with Tybost.
Slovenian: Nekaterih zdravil nikoli ne smete jemati z zdravilom Tybost.
English: A long term carcinogenicity study of cobicistat in rats revealed tumourigenic potential specific for this species that is regarded as of no relevance for humans.
Slovenian: Dolgoročna študija kancerogenosti kobicistata pri podganah je pokazala tumorogeni potencial, specifičen za to vrsto, za katerega prevladuje mnenje, da za človeka ni pomemben.
English: Your doctor will carefully consider whether to treat you with Tybost.
Slovenian: Vaš zdravnik bo temeljito premislil, ali se smete zdraviti z zdravilom Tybost.
English: Table 2: Interactions between cobicistat and other medicinal products
Slovenian: Preglednica 2: Interakcije med kobicistatom in drugimi zdravili
English: A food effect study was not conducted for Tybost.
Slovenian: Za zdravilo Tybost niso izvedli študije o učinku hrane.
English: Concentrations of these medicinal products may be increased when co-administered with Tybost resulting in the potential for increased adverse events usually associated with these anticancer medicinal products.
Slovenian: Koncentracije teh zdravil se lahko pri sočasnem dajanju z zdravilom Tybost zvišajo, zaradi česar je možno povečanje neželenih učinkov, ki so običajno povezani s temi zdravili proti raku.
English: However, patients should be informed that dizziness has been reported during treatment with cobicistat-containing regimens.
Slovenian: Bolnike je treba obvestiti, da so med zdravljenjem z režimi, ki so vključevali kobicistat, poročali o omotici.
English: Virologic response rate was evaluated in both treatment arms and virologic response was defined as achieving an undetectable viral load (< 50 HIV-1 RNA copies/ml).
Slovenian: Stopnja virološkega odziva je bila ocenjena v obeh krakih zdravljenja, virološki odziv je bil opredeljen kot dosežena nezaznavna virusna obremenitev (< 50 RNA HIV-1 kopij/ml).
English: Hepatitis B and/or hepatitis C virus co-infection
Slovenian: Sočasna okužba z virusom hepatitisa B in/ali hepatitisa C
English: Increased plasma concentrations of salmeterol are associated with the potential for serious and/or life-threatening reactions.
Slovenian: Zvišanje koncentracij salmeterola v plazmi je povezano z možnimi resnimi in/ali življenjsko nevarnimi reakcijami.
English: Macrolide antibiotics Clarithromycin
Slovenian: Makrolidni antibiotiki klaritromicin
English: • oral or implanted hormonal contraceptives used to prevent pregnancy
Slovenian: • peroralni hormonski kontraceptivi ali hormonski kontraceptivi v obliki vsadka, ki se uporabljajo za preprečevanje nosečnosti
English: Pregnant women should not take Tybost with darunavir.
Slovenian: Nosečnice ne smejo jemati zdravila Tybost z darunavirjem.
English: Do not stop your treatment without contacting your doctor.
Slovenian: Ne prekinite zdravljenja brez posvetovanja z zdravnikom.
English: Concomitant use contraindicated
Slovenian: Kontraindicirana sočasna uporaba
English: • 12 hours or more after the time you usually take Tybost, then do not take the missed dose.
Slovenian: • po 12 urah ali več od časa, ko običajno vzamete zdravilo Tybost, pozabljenega odmerka ne vzemite.
English: Pharmacotherapeutic group: All other therapeutic products, ATC code: V03AX03
Slovenian: Farmakoterapevtska skupina: druga nerazvrščna zdravila za različne bolezni, oznaka ATC: V03AX03
English: The substantial reduction in darunavir exposure may result in virological failure and an increased risk of mother-to-child transmission of HIV infection.
Slovenian: Pomembno zmanjšanje izpostavljenosti darunavirju lahko povzroči virološki neuspeh in povečano tveganje za prenos okužbe s HIV z matere na otroka.
English: Effects on estimated creatinine clearance
Slovenian: Učinki na ocenjeni očitek kreatinina
English: Following oral administration of [14C]cobicistat, 99% of circulating radioactivity in plasma was unchanged cobicistat.
Slovenian: Po peroralnem dajanju [14C]kobicistata je bilo 99 % cirkulirajoče radioaktivnosti v plazmi nespremenjeni kobicistat.
English: Contraception requirements
Slovenian: Zahteve po kontracepciji
English: At week 96 the mean change in serum creatinine was 0.07 ± 0.15 mg/dl and the mean change in eGFR by Cockcroft-Gault method was -6.2 ± 9.07 ml/min.
Slovenian: V 96. tednu je bila povprečna sprememba serumskega kreatinina 0,07 ± 0,15 mg/dl in povprečna sprememba eGFR po Cockcroft-Gaultovi metodi -6,2 ± 9,07 ml/min.
English: Ex vivo rabbit studies and in vivo dog studies suggest that cobicistat has a low potential for QT prolongation, and may slightly prolong the PR interval and decrease left ventricular function at mean concentrations at least 10-fold higher than the human exposure at the recommended 150 mg daily dose.
Slovenian: Študije pri kuncih ex vivo in pri psih in vivo kažejo, da ima kobicistat nizek potencial za podaljšanje intervala QT in da lahko nekoliko podaljša interval PR ter zmanjša delovanje levega prekata pri koncentracijah, ki so vsaj 10-krat višje kot izpostavljenost pri človeku ob priporočenem dnevnem odmerku 150 mg.
English: Animal studies do not indicate direct or indirect harmful effects of cobicistat with respect to reproductive toxicity (see section 5.3).
Slovenian: Študije na živalih ne kažejo neposrednih ali posrednih škodljivih učinkov kobicistata na sposobnost razmnoževanja (glejte poglavje 5.3).
English:  If any of these applies to you, talk to your doctor before taking Tybost.
Slovenian:  Če kar koli od navedenega velja za vas, se pred jemanjem zdravila Tybost posvetujte s svojim zdravnikom.
English: DOAC = direct oral anticoagulant 1 Study was conducted with tenofovir disoproxil fumarate
Slovenian: DOAC = neposredni peroralni antikoagulant 1 Študijo so izvedli z dizoproksiltenofovirat fumaratom
English: Randomisation was stratified by screening HIV-1 RNA level (≤ 100,000 copies/ml or > 100,000 copies/ml).
Slovenian: Randomizacija je bila stratificirana s presejanjem ravni RNA HIV-1 (≤ 100.000 kopij/ml ali > 100.000 kopij/ml).
English: If you take more Tybost than you should
Slovenian: Če ste vzeli večji odmerek zdravila Tybost, kot bi smeli
English: Increased monitoring for rifabutin-associated adverse reactions including neutropenia and uveitis is warranted due to an expected increase in exposure to desacetyl-rifabutin.
Slovenian: Upravičeno je povečano spremljanje neželenih učinkov, povezanih rifabutinom, vključno z nevtropenijo in uveitisom, zaradi pričakovane večje izpostavljenosti desacetil-rifabutinu.
English: Cobicistat has no detectable antiviral activity against HIV-1, HBV or HCV and does not antagonise the antiviral effect of HIV inhibitors.
Slovenian: Kobicistat nima zaznavne protivirusne aktivnosti proti HIV-1, HBV or HCV in na protivirusne učinke zaviralcev HIV ne deluje antagonistično.
English: EU/1/13/872/001 30 film-coated tablets EU/1/13/872/002 90 (3 bottles of 30) film-coated tablets
Slovenian: ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/13/872/001 30 filmsko obloženih tablet EU/1/13/872/002 90 (3 plastenke po 30) filmsko obloženih tablet
English: Tybost comes in bottles of 30 tablets (with a silica gel sachet or canister that must be kept in the bottle to help protect your tablets).
Slovenian: Zdravilo Tybost je na voljo v plastenkah po 30 tablet (s silikagelskim sušilnim sredstvom v vrečici ali vsebniku, ki mora ostati v plastenki zaradi zaščite tablet).
English: Higher plasma concentrations of co-administered medicinal products can result in increased or prolonged therapeutic effects or adverse reactions.
Slovenian: Višje koncentracije sočasno dajanih zdravil lahko povzročijo povečan ali podaljšan terapevtski učinek ali neželene učinke.
English: Dose reductions of colchicine may be required.
Slovenian: Morda bo treba odmerek kolhicina zmanjšati.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of cobicistat/metabolites in milk.
Slovenian: Razpoložljivi farmakodinamični/toksikološki podatki pri živalih kažejo na izločanje kobicistata/presnovkov v mleko.
English: What Tybost is and what it is used for What you need to know before you take Tybost How to take Tybost
Slovenian: Kaj je zdravilo Tybost in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Tybost Kako jemati zdravilo Tybost Možni neželeni učinki
English: Of these 692 patients, 613 (300 atazanavir/cobicistat and 313 atazanavir/ritonavir) and 496 (250 atazanavir/cobicistat and 246 atazanavir/ritonavir) received at least 48 and 144 weeks of treatment, respectively.
Slovenian: Med temi 692 bolniki se jih je 613 (300 atazanavir/kobicistat in 313 atazanavir/ritonavir) zdravilo vsaj 48 tednov in 496 (250 atazanavir/kobicistat in 246 atazanavir/ritonavir) vsaj 144 tednov.
English: • neuroleptics/antipsychotics: pimozide, lurasidone
Slovenian: • nevroleptiki/antipsihotiki: pimozid/lurasidon
English: If the patient misses a dose of Tybost within 12 hours of the time it is usually taken, the patient should take Tybost with food as soon as possible and resume their normal dosing schedule in combination with atazanavir or darunavir.
Slovenian: Če bolnik izpusti odmerek zdravila Tybost v roku 12 ur od časa, ko ga običajno vzame, naj bolnik vzame zdravilo Tybost s hrano takoj, ko je mogoče, nato pa nadaljuje s svojim običajnim režimom odmerjanja v kombinaciji z atazanavirjem ali darunavirjem.
English: Plasma levels of cobicistat and consequently of atazanavir may decrease significantly during pregnancy.
Slovenian: Ravni kobicistata in posledično atazanavirja v plazmi se lahko med nosečnostjo pomembno zmanjšajo.
English: Cobicistat inhibits the transporters P-gp, BCRP, MATE1, OATP1B1 and OATP1B3.
Slovenian: Kobicistat zavira prenašalce P-gp, BCRP, MATE1, OATP1B1 in OATP1B3.
English: e Includes subjects who discontinued for reasons other than an adverse event, death, or lack or loss of efficacy,
Slovenian: e Vključuje osebe, ki so sodelovanje prekinile zaradi razlogov, ki niso neželeni učinki, smrt ali pomanjkanje ali izguba učinkovitosti, npr. umik soglasja, izgubljeni za spremljanje.
English: Animal studies do not indicate harmful effects of cobicistat on fertility.
Slovenian: Študije na živalih ne kažejo škodljivih učinkov kobicistata na plodnost.
English: Tybost should not be used in combination with other medicinal products containing cobicistat or with ritonavir due to similar effects of cobicistat and ritonavir on CYP3A.
Slovenian: Zdravila Tybost se ne sme uporabljati v kombinaciji z drugimi zdravili, ki vsebujejo kobicistat, ali z ritonavirjem zaradi podobnih učinkov kobicistata in ritonavirja na encim CYP3A.
English: • PDE-5 inhibitors: sildenafil for treatment of pulmonary arterial hypertension
Slovenian: • zaviralci PDE-5: sildenafil za zdravljenje pljučne arterijske hipertenzije
English: Always keep enough Tybost so you don't run out.
Slovenian: Vedno ohranjajte zadostno količino zdravila Tybost, da vam ga ne zmanjka.
English: hyperglycaemia, increased appetite Psychiatric disorders:
Slovenian: hiperglikemija, zvečan apetit Psihiatrične motnje:
English: There are currently inadequate data to determine whether co-administration of tenofovir disoproxil and cobicistat is associated with a greater risk of renal adverse reactions compared with regimens that include tenofovir disoproxil without cobicistat.
Slovenian: Trenutni podatki ne zadoščajo za ugotovitev, ali je sočasna uporaba tenofovirdizoproksila in kobicistata povezana z večjim tveganjem za neželene učinke na ledvice v primerjavi z režimi, ki vključujejo tenofovirdizoproksil brez kobicistata.
English: Selective Serotonin Reuptake Inhibitors (SSRIs) Trazodone
Slovenian: Selektivni zaviralci ponovnega privzema serotonina (SSRI, Selective Serotonin Reuptake Inhibitors) trazodon
English: When administering ketoconazole with Tybost, the maximum daily dose of ketoconazole should not exceed 200 mg per day.
Slovenian: Pri dajanju ketokonazola z zdravilom Tybost največji dnevni odmerek ketokonazola ne sme preseči 200 mg dnevno.
English: If overdose occurs the patient must be monitored for evidence of toxicity (see section 4.8).
Slovenian: V primeru prevelikega odmerka je potrebno bolnika nadzorovati glede možnih znakov toksičnosti (glejte poglavje 4.8).
English: Ethnicity
Slovenian: Etničnost
English: If alternatives cannot be used, its use should only take place after medical evaluation and under close monitoring by your doctor for corticosteroid side effects.
Slovenian: Kadar ni mogoče uporabiti drugih zdravil, se lahko uporabljajo le po zdravniškem pregledu in ob natančnem zdravniškem spremljanju zaradi možnosti pojava neželenih učinkov, povezanih s kortikosteroidi
English: There is no specific antidote for overdose with cobicistat.
Slovenian: Specifičnega antidota za preveliko odmerjanje kobicistata ni.
English: An increase of > 3 x ULN in alanine aminotransferase or aspartate aminotransferase was recorded in 12.8% of subjects in the cobicistatboosted group and 9.0% in the ritonavir-boosted group.
Slovenian: Povečanje za > 3 x ULN alanin aminotransferaze ali aspartat aminotransferaze so zabeležili pri 12,8 % bolnikov v skupini zdravila, okrepljenega s kobicistatom, in 9,0 % v skupini zdravila, okrepljenega z ritonavirjem.
English: Darunavir/ritonavir may be considered as an alternative.
Slovenian: Kot alternativa lahko prideta v poštev darunavir/ritonavir.
English: Tybost taken with atazanavir or darunavir should not be used with another antiviral medicine that requires boosting.
Slovenian: Zdravila Tybost, ki ga jemljete z atazanavirjem ali darunavirjem, se ne sme uporabljati z drugim protivirusnim zdravilom, ki ga je treba okrepiti.
English: However, a higher percentage of subjects in the cobicistat-boosted group had increases in total bilirubin > 2 x ULN than those in the ritonavir-boosted group (88.0% versus 80.9%).
Slovenian: Vendar pa je imel višji odstotek bolnikov v skupini skupini zdravila, okrepljenega s kobicistatom, povišan skupni bilirubin > 2 x ULN kot v skupini zdravila, okrepljenega z ritonavirjem (88,0 % v primerjavi s 80,9 %).
English: • vomiting, diarrhoea, stomach pain, problems with digestion resulting in pain after meals
Slovenian: • bruhanje, driska, bolečine v trebuhu, težave s prebavo, ki po obroku povzročijo bolečine
English: Other medicines and Tybost Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali boste morda začeli jemati katero koli drugo zdravilo.
English: • Do not breast-feed during treatment with Tybost.
Slovenian: • Med zdravljenjem z zdravilom Tybost ne dojite.
English: In Study GS-US-216-0114, decreases in estimated creatinine clearance occurred early in treatment with cobicistat, after which they stabilised.
Slovenian: V študiji GS-US-216-0114 se je znižanje ocenjenega očistka kreatinina pri zdravljenju s kobicistatom pojavilo na začetku zdravljenja, nakar se je stabiliziralo.
English:  If any of these applies to you, you should not take Tybost and you should tell your doctor immediately.
Slovenian:  Če to velja za vas, ne jemljite zdravila Tybost in o tem nemudoma obvestite svojega zdravnika.
English: For medicinal products metabolised by CYP3A these higher plasma concentrations may potentially lead to serious and/or life-threatening events (see section 4.3).
Slovenian: Pri zdravilih, ki jih presnavlja CYP3A, lahko te višje koncentracije v plazmi povzročijo resne in/ali življenjsko nevarne dogodke (glejte poglavje 4.3).
English: No teratogenic effects were observed in rats and rabbit developmental toxicity studies.
Slovenian: V študijah razvojne toksičnosti pri podganah in kuncih niso opazili teratogenih učinkov.
English: It is important not to miss a dose of Tybost.
Slovenian: Pomembno je, da ne pozabite vzeti nobenega odmerka zdravila Tybost.
English: Tybost is indicated as a pharmacokinetic enhancer of atazanavir 300 mg once daily or darunavir 800 mg once daily as part of antiretroviral combination therapy in human immunodeficiency virus-1 (HIV-1) infected adults.
Slovenian: Zdravilo Tybost je indicirano kot farmakokinetični ojačevalec atazanavirja 300 mg enkrat na dan ali darunavirja 800 mg enkrat na dan kot del protiretrovirusnega kombiniranega zdravljenja pri odraslih, okuženih z virusom humane imunske pomanjkljivosti 1 (HIV-1).
English: Co-administration is contraindicated with medicinal products that are strong inducers of CYP3A due to the potential for loss of therapeutic effect.
Slovenian: Sočasno dajanje je kontraindicirano z zdravili, ki so močni induktorji CYP3A zaradi potencialne izgube terapevtskega učinka.
English: The active substance cobicistat is persistent in the environment.
Slovenian: Učinkovina kobicistat je v okolju obstojna.
English: • sildenafil and vardenafil, medicines used to treat impotence, and tadalafil, a medicine used to treat impotence and pulmonary hypertension
Slovenian: • sildenafil in vardenafil; zdravili, ki se uporabljata za zdravljenje impotence, in tadalafil, zdravilo, ki se uporablja za zdravljenje impotence in pljučne hipertenzije
English: Co-administration is not recommended.
Slovenian: Sočasnega dajanja se ne priporoča.
English: Digoxin:
Slovenian: digoksin:
English: • trazodone, a medicine used to treat depression
Slovenian: • trazodon; zdravilo, ki se uporablja za zdravljenje depresije
English: Each tablet contains 59 micrograms sunset yellow FCF aluminium lake (E110).
Slovenian: Ena tableta vsebuje 59 mikrogramov barvila sončno rumeno FCF (E110).
English: Therefore, Tybost should not be used during breast-feeding.
Slovenian: Zdravila Tybost se med dojenjem ne sme uporabljati.
English: See sections 4.4, 4.8 and 5.2.
Slovenian: Glejte poglavja 4.4, 4.8 in 5.2.
English: In treatment-naïve HIV-1 infected patients
Slovenian: Pri predhodno nezdravljenih bolnikih, okuženih s HIV-1
English: Sunset yellow FCF aluminium lake (E110), macrogol 3350 (E1521), polyvinyl alcohol (partially hydrolysed) (E1203), talc (E553B), titanium dioxide (E171), iron oxide yellow (E172) (see section 2 of this leaflet).
Slovenian: Barvilo sončno rumeno FCF (E110), makrogol 3350 (E1521), polivinilalkohol (delno hidroliziran) (E1203), smukec (E553B), titanov dioksid (E171), rumeni železov oksid (E172) (glejte poglavje 2 v tem navodilu).
English: An increase from baseline in serum creatinine solely due to cobicistat's inhibitory effect generally does not exceed 0.4 mg/dl.
Slovenian: Zvišanje serumskega kreatinina samo zaradi zaviralnega učinka kobicistata v primerjavi z izhodiščnimi vrednostmi v splošnem ne preseže 0,4 mg/dl.
English: Cobicistat is a weak CYP2D6 inhibitor and is metabolised to a minor extent by CYP2D6.
Slovenian: Kobicistat je šibak zaviralec CYP2D6, ki ga v manjšem obsegu presnavlja CYP2D6.
English: Following oral administration of [14C]cobicistat, 86% and 8.2% of the dose were recovered in faeces and urine, respectively.
Slovenian: Po peroralni uporabi [14C]kobicistata so 86 % in 8,2 % odmerka izolirali iz blata oz. urina.
English: High density polyethylene (HDPE) bottle with a polypropylene child-resistant closure containing 30 film-coated tablets and a silica gel desiccant.
Slovenian: Plastenka iz polietilena visoke gostote (HDPE) s polipropilensko, za otroke varno zaporko, ki vsebuje 30 filmsko obloženih tablet in silikagelsko sušilno sredstvo.
English: • increased levels of bilirubin in the blood (hyperbilirubinaemia)
Slovenian: • zvišane ravni bilirubina v krvi (hiperbilirubinemija)