FrancophonIA/ELRC3.0 huggingface dataset:
English: • if you have heart problems such as cardiogenic shock, or left ventricular failure with low filling pressure or cardiac decompensation or shock.
Slovenian: • če imate težave s srcem, na primer kardiogeni šok, popuščanje levega prekata z nizkim polnilnim tlakom ali srčno dekompenzacijo ali šok.
English: Other side effects include: Very common (may affect more than 1 in 10 people)
Slovenian: Med drugimi neželenimi učinki so: Zelo pogosti (pojavijo se lahko pri več kot 1 od 10 oseb)
English: <Invented name> is used to prevent or attenuate painful, straining symptoms (angina pectoris) of your heart disease.
Slovenian: Zdrvilo <Izmišljeno ime> uporabljamo za ublažitev bolečih, tiščočih simptomov (angine pektoris), ki jih povzroča srčna bolezen.
English: Absorption After oral administration, nicorandil is absorbed rapidly and completely from the gastrointestinal tract, independent from food intake.
Slovenian: Po peroralni uporabi se nikorandil hitro in popolnoma absorbira iz prebavil, neodvisno od uživanja hrane.
English: The other metabolites accounted for the remaining 20% of radioactive AUC.
Slovenian: Preostalih 20 % AUC radioaktivnosti je šlo na račun drugih presnovkov.
English: Although any accidental intake of this desiccant is usually harmless, it may alter the scheduled intake of the active tablets.
Slovenian: Naključno zaužitje sušila je sicer po navadi neškodljivo, vendar lahko spremeni pravilen urnik jemanja tablet z zdravilno učinkovino.
English: It is not known whether nicorandil passes in human milk.
Slovenian: Ni znano, ali nikorandil pri človeku prehaja v materino mleko.
English: It improves the blood and oxygen supply of your heart muscle and reduces its workload.
Slovenian: Izboljša oskrbo srčne mišice s krvjo in kisikom in srčno mišico razbremeni.
English: The tablets are sensitive to moisture; hence the patients should be advised to keep the tablets in their blister until intake.
Slovenian: Tablete so občutljive na vlago, zato je treba bolnikom naročiti, naj jih do zaužitja hranijo v pretisnem omotu.
English: <Invented name> with alcohol
Slovenian: Zdravilo <Izmišljeno ime> skupaj z alkoholom
English: If nicorandil is used concomitantly with antihypertensive agents or other medicinal products with blood pressure lowering effect (e.g. vasodilators, tricyclic antidepressants, alcohol), the blood pressure lowering effect may be increased.
Slovenian: Če je nikorandil uporabljen sočasno z antihipertenzivnimi zdravili ali drugimi zdravili, ki znižujejo krvni tlak (npr. z vazodilatatorji, tricikličnimi antidepresivi, alkoholom), se lahko njegov učinek na znižanje krvnega tlaka poveča.
English: Nicorandil, a nicotinamide ester, is a vasodilator agent with a dual mechanism of action, which leads to relaxation of smooth tonic vascular muscles in both venous and arterial part of vessels.
Slovenian: Nikorandil, nikotinamidni ester, je vazodilatator z dvojnim mehanizmom delovanja, ki povzroči sprostitev gladkih toničnih žilnih mišic v venskem in arterijskem ožilju.
English: Tell your doctor, if you are taking any of the following:
Slovenian: Zdravniku morate povedati, če jemljete kaj od naslednjega:
English: • if you are taking medicines to treat erectile dysfunction such as sildenafil, tadalfil, vardenafil (phosphodiesterase inhibitors) or medicines to treat pulmonary hypertension such as riociguat (guanylate cyclase stimulators).
Slovenian: • če jemljete zdravila proti erektilni disfunkciji, na primer sildenafil, tadalafil, vardenafil (zaviralce fosfodiesteraze), ali zdravila za zdravljenje pljučne hipertenzije, na primer riociguat (stimulatorje gvanilatciklaze).
English: Dapoxetine should be prescribed with caution in patients taking nicorandil due to possible reduced orthostatic tolerance.
Slovenian: Bolnikom, ki jemljejo nikorandil, je treba zaradi možnega zmanjšanja ortostatske tolerance dapoksetin predpisovati previdno.
English: There was no evidence of teratogenicity (rat and rabbit), or abnormal pre- or post-natal physical or behavioural development (rat).
Slovenian: Znakov teratogenosti ni bilo (podgane in kunci), prav tako ni bilo nenormalnosti v telesnem ali vedenjskem razvoju pred skotitvijo ali po njej (podgane).
English: Patients with liver and/or renal impairment There are no special dosage requirements for patients with liver and/or renal impairment.
Slovenian: Bolniki z insuficienco jeter in/ali ledvic Za odmerjanje pri bolnikih z okvaro jeter/ali in ledvic ni posebnih zahtev.
English: Other medicines and <Invented name>
Slovenian: Druga zdravila in zdravilo <Izmišljeno ime>
English: In plasma unchanged nicorandil accounted for 45.5% of the radioactive AUC and the alcohol metabolite, N-(2-hydroxyethyl)-nicotinamide for 40.5%.
Slovenian: plazmi je šlo na račun nespremenjenega nikorandila 45,5 % AUC radioaktivnosti in na račun alkoholnega presnovka N-(2-hidroksietil)-nikotinamida 40,5 %.
English: • Patients with shock (including cardiogenic shock), severe hypotension, or left ventricular dysfunction with low filling pressure or cardiac decompensation
Slovenian: • Bolniki s šokom (tudi kardiogenim šokom), hudo hipotenzijo ali z motenim delovanjem levega prekata z nizkim polnilnim tlakom ali srčno dekompenzacijo.
English: The only possible treatment is to stop nicorandil.
Slovenian: Edino možno zdravljenje je prenehanje uporabe nikorandila.
English: It possesses a potassium-channel opening effect.
Slovenian: Učinkuje tudi na odprtje kalijevih kanalčkov.
English: • Eye injuries
Slovenian: • Poškodbe oči • Okvare roženice
English: If you forget to take <Invented name>
Slovenian: Če ste pozabili vzeti zdravilo <Izmišljeno ime>
English: You should not breast-fed while you are taking this medicine.
Slovenian: Med jemanjem tega zdravila ne smete dojiti.
English: You may feel blood pressure lowering effect such as dizziness, feeling of weakness.
Slovenian: Pojavijo se vam lahko simptomi, ki so posledica znižanja krvnega tlaka, na primer omotica ali občutek šibkosti.
English: Nicorandil and its metabolites are mainly excreted by urinary route, faecal excretion being very low.
Slovenian: Nikorandil in njegovi presnovki se v glavnem izločijo v urinu; izločanja v blatu je zelo malo.
English: • Medicines to treat pulmonary hypertension such as riociguat.
Slovenian: • zdravila za zdravljenje pljučne hipertenzije, na primer riociguat.
English: In addition, the following adverse reactions have been reported with different frequencies in the IONA (Impact of Nicorandil in Angina) study, where nicorandil has been used on top of standard therapy in patients with stable angina and at high risk of cardiovascular events (see section 5.1).
Slovenian: Poleg tega so bili v študiji IONA (Impact of Nicorandil in Angina - vpliv nikorandila pri angini pektoris) zabeleženi naslednji neželeni učinki z drugačnimi pogostnostmi; v študiji so nikorandil uporabljali poleg standardnega zdravljenja pri bolnikih s stabilno angino pektoris in velikim tveganjem za srčno-žilne dogodke (glejte poglavje 5.1).
English: • If you have a low blood pressure.
Slovenian: • če imate nizek krvni tlak.
English: Nicorandil may lower your blood pressure.
Slovenian: Nikorandil lahko zniža krvni tlak.
English: It is included in the pack to protect <Invented name> tablets from moisture.
Slovenian: Tableta sušila je v pakiranju zato, da zavaruje tablete zdravila <Izmišljeno ime> pred vlago.
English: This effect can be increased in conjunction with alcohol or other medicinal products with blood pressure lowering effect (e.g. vasodilators, tricyclic antidepressants) (see section 4.5).
Slovenian: Ta učinek se lahko poveča ob hkratnem uživanju alkohola ali drugih zdravil, ki znižajo krvni tlak (na primer vazodilatatorji ali triciklični antidepresivi) (glejte poglavje 4.5).
English: Ulcers can occur at other site such as: skin, genital tract and nasal passages or around a stoma (in those with an artificial opening for waste removal such as a colostomy or ileostomy).
Slovenian: Razjede se lahko pojavijo tudi na drugih mestih, na primer na koži, spolovilih, nosnih prehodih ali okrog stome (pri osebah, ki imajo umetno odprtino za odstranjevanje iztrebkov, npr. kolostomijo ali ileostomijo).
English: Do not take out or separate tablet from the blister strip until intake.
Slovenian: Tablete ne jemljite iz pretisnega omota in je ne ločujte, dokler ni čas za njeno zaužitje.
English: Furthermore, nicorandil has demonstrated a spasmolytic activity in both in vitro and in vivo studies and reverses coronary spasm induced by methacholine or noradrenalin.
Slovenian: Poleg tega je nikorandil v študijah in vitro in in vivo pokazal spazmolitično delovanje in odpravo koronarnega spazma, povzročenega z metaholinom ali noradrenalinom.
English: <Invented name> is indicated in adults for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled or have a contraindication or intolerance to first-line antianginal therapies (such as beta-blockers and/or calcium antagonists).
Slovenian: Zdravilo <Izmišljeno ime> je indicirano za simptomatsko zdravljenje odraslih bolnikov s stabilno angino pektoris, ki bolezni nimajo ustrezno urejene z antianginoznimi zdravili prve izbire (na primer z antagonisti adrenergičnih receptorjev beta in/ali zaviralci kalcijevih kanalčkov), imajo kontraindikacijo za takšna zdravila ali jih ne prenesejo.
English: • If your eyes become red, itchy or swollen.
Slovenian: • Če vam oči pordijo, postanejo srbeče ali otečejo.
English: The metabolism of organic nitrates can result in the formation of nitrites which may trigger methemoglobinemia in patients with glucose-6-phosphate dehydrogenase deficiency.
Slovenian: Presnova organskih nitratov lahko - zaradi organske nitratne skupine nikorandila - povzroči nastanek nitritov, ti pa lahko pri bolnikih s pomanjkanjem glukoza-6-fosfat dehidrogenaze sprožijo methemoglobinemijo.
English: There are no or limited amount of data from the use of nicorandil in pregnant women.
Slovenian: O uporabi nikorandil pri nosečnicah je podatkov malo ali jih ni.
English: Therapeutic doses of nicorandil may lower the blood pressure.
Slovenian: Terapevtski odmerki nikorandila lahko znižajo krvni tlak.
English: G6PD deficiency <Invented name> should be used with caution in patients with glucose-6-phosphate-dehydrogenase deficiency.
Slovenian: Zdravilo <Izmišljeno ime> je treba pri bolnikih s pomanjkanjem glukoza-6-fosfat dehidrogenaze uporabljati previdno.
English: Concurrent use of nicorandil and phosphodiesterase 5 inhibitors, e.g. sildenafil, tadalafil, vardenafil, is contraindicated, since it can lead to a serious drop in blood pressure (synergic effect).
Slovenian: Sočasna uporaba nikorandila in zaviralcev fosfodiesteraze 5, npr. sildenafila, tadalafila, vardenafila, je kontraindicirana, ker lahko povzroči resen padec krvnega tlaka (sinergičen učinek).
English: N-(2-hydroxyethyl)-nicotinamide is the most abundant metabolite (about 8.9% of the administered dose within 48 hours) followed by nicotinuric acid, (5.7%), nicotinamide (1.34%), N-methyl-nicotinamide (0.61%) and nicotinic acid (0.40%).
Slovenian: uporabljenega odmerka v 48 urah), sledijo nikotinurična kislina (5,7 %), nikotinamid (1,34 %), N-metil nikotinamid (0,61 %) in nikotinska kislina (0,40 %).
English: Liver disorders such as hepatitis, cholestasis, or jaundice
Slovenian: žolčnika in žolčevodov jetrne bolezni, na primer hepatitis, holestaza ali zlatenica
English: The frequencies of adverse reactions reported with nicorandil are summarised in the following table by system organ class (in MedDRA) and by frequency.
Slovenian: Pogostnosti neželenih učinkov, zabeleženih med uporabo nikorandila, so povzete v naslednji preglednici po organskih sistemih (MedDRA) in pogostnosti.
English: Following exposure to nicorandil at doses that were maternally toxic, embryotoxicity was observed in the rat and rabbit.
Slovenian: Po izpostavljenosti nikorandilu v odmerkih, toksičnih za samice matere, so pri podganah in kuncih opažali embriotoksične učinke.
English: This can develop problems such as bleeding (blood in your stools or vomit), fistula (abnormal tube-like passage from one body cavity to another or to the skin), wholes, abscess, weight loss.
Slovenian: To lahko povzroči težave, kot so krvavitev (kri v blatu ali izbruhani vsebini), fistula (nenormalna cevasta povezava med dvema telesnima votlinama ali med telesno votlino in kožo), predrtje, ognojek (absces), hujšanje.
English: Besides the nicorandil tablets, each blister contains active substance-free silica gel tablets as desiccant in a separate blister segment which is marked accordingly.
Slovenian: Poleg tablet nikorandila vsak pretisni omot kot sušilo vsebuje tablete silicijevega dioksida, ki ne vsebujejo zdravilne učinkovine; tablete sušila so v ločenem delu pretisnega omota, ki je ustrezno označen.
English: This activation of potassium channels induces vascular cell membrane hyperpolarisation with an arterial muscle relaxant effect, thereby leading to arterial dilatation and afterload reduction.
Slovenian: Aktiviranje kalijevih kanalčkov povzroči hiperpolarizacijo membrane žilnih celic in sprostitev arterijskih mišic, s posledičnim razširjenjem arterij in zmanjšanjem sistoličnega bremena ("afterload").
English: This can develop problems such as bleeding, fistula, wholes, abscess, especially if you have diverticular disease
Slovenian: To lahko povzroči težave, kot so krvavitev, fistula, predrtje ali ognojek (absces), še zlasti če imate divertikularno bolezen (bolezen prebavil, ki prizadene debelo črevo).
English: Due to lack of data, caution is advised to use nicorandil in patients with heart failure class NHYA III or IV.
Slovenian: Srčno popuščanje Zaradi pomanjkanja podatkov je treba nikorandil previdno uporabljati pri bolnikih s srčnim popuščanjem razreda III ali IV po NYHA.
English: • Use of soluble guanylate cyclase stimulator(s) (such as riociguat) since it can lead to a serious fall in blood pressure (see section 4.5)
Slovenian: • Uporaba topnih stimulatorjev gvanilatciklaze (npr. riociguata), ker lahko povzroči resen padec krvnega tlaka (glejte poglavje 4.5).
English: Nicorandil has no direct effect on myocardial contractility.
Slovenian: Nikorandil ne vpliva neposredno na krčljivost miokarda.
English: Stop taking straight away nicorandil and talk to your doctor if you experience any of the following:
Slovenian: Takoj prenehajte jemati nikorandil in se posvetujte z zdravnikom, če se vam pojavi kaj od naslednjega:
English: At steady state, the accumulation ratio (based on AUC) is around 2 for 20 mg bid tablet and 1.7 for 10 mg bid tablet.
Slovenian: V stanju dinamičnega ravnovesja je razmerje kopičenja (na podlagi AUC) med uporabo 20-mg tablet dvakrat na dan okoli 2 in med uporabo 10-mg tablet dvakrat na dan okoli 1,7.
English: Therefore caution is advised when concomitant use of acetylsalicylic acid or NSAIDs and nicorandil is considered (see section 4.5).
Slovenian: Zato je v primeru razmisleka o sočasni uporabi acetilsalicilne kisline ali NSAID in nikorandila potrebna previdnost (glejte poglavje 4.5).
English: Concomitant use of soluble guanylate cyclase stimulator (such as riociguat) is contraindicated, since it can lead to a serious drop in blood pressure.
Slovenian: Sočasna uporaba topnih stimulatorjev gvanilatciklaze (npr. riociguata) je kontraindicirana, ker lahko povzroči resen padec krvnega tlaka.
English: Hyperkalaemi a (see section 4.4 and 4.5)
Slovenian: Presnovne in prehranske motnje hiperkaliemija (glejte poglavji 4.4 in 4.5)
English: These results suggest that testicular toxicity by nicorandil is related to a sustained decrease in blood flow caused by reduction of cardiac output.
Slovenian: Ti rezultati kažejo, da je testikularna toksičnost nikorandila povezana s stalnim zmanjšanjem krvnega pretoka, ki ga povzroči zmanjšanje minutnega volumna srca.
English: Do not swallow the drying agent which is the bigger tablet on one end of each blister strip.
Slovenian: Sušilo je večja tableta, pakirana na enem koncu vsakega pretisnega traku.
English: Patients taking acetylsalicylic acid or NSAIDs (Non Steroid Anti Inflammatory Drugs) concomitantly are at increased risk for severe complications such as gastrointestinal haemorrhage.
Slovenian: Bolniki, ki sočasno jemljejo acetilsalicilno kislino ali NSAID (“Non-Steroidal Anti-Inflammatory Drugs”) (nesteroidna protivnetna zdravila), imajo večje tveganje za hude zaplete, kot je krvavitev v prebavilih.
English: Musculoskeletal and connective tissue disorders
Slovenian: Bolezni mišično skeletnega sistema in vezivnega tkiva mialgija
English: Driving and using machines <Invented name> may cause dizziness or weakness.
Slovenian: Zdravilo <Izmišljeno ime> lahko povzroči omotico ali šibkost.
English: If advanced, ulcers may develop into perforation, fistula, or abscess formation.
Slovenian: Napredovale razjede se lahko razvijejo v perforacijo, fistulo ali absces.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON for 10 mg and 20 mg
Slovenian: PODATKI NA ZUNANJI OVOJNINI ZUNANJA OVOJNINA za 10 mg in 20 mg
English: The metabolism of nicorandil is not significantly affected by cimetidine (a CYP inhibitor), or rifampicin (a CYP3A4 inducer).
Slovenian: Cimetidin (zaviralec CYP) in rifampicin (induktor CYP3A4) ne vplivata pomembno na presnovo nikorandila.
English: It is used in adult patients who do not tolerate or cannot take heart medicines called beta-blockers and/or calcium antagonists.
Slovenian: Uporabljamo ga pri odraslih bolnikih, ki ne prenesejo ali ne smejo jemati zdravil za srce iz skupine antagonisti adrenergičnih receptorjev beta, zaviralci kalcijevih kanalčkov ali obojih.
English: Nicorandil is principally metabolised in the liver by denitration in a series of compounds without cardiovascular activity.
Slovenian: Biotransformacija Nikorandil se v glavnem presnovi v jetrih z denitracijo v vrsto spojin, ki nimajo srčno-žilnih učinkov.
English: The composite primary endpoint (coronary heart disease (CHD) death, non-fatal myocardial infarction, or unplanned hospital admission for cardiac chest pain), occurred in 337 patients (13.1%) of patients treated with nicorandil 20 mg twice daily compared with 389 patients (15.5%) of patients receiving placebo (hazard ratio 0.83; 95% confidence interval (CI) 0.72 to 0.97; p=0.014).
Slovenian: (13,1 %), ki so prejemali nikorandil 20 mg dvakrat na dan, in pri 389 bolnikih (15,5 %), ki so prejemali placebo (razmerje ogroženosti 0,83, interval zaupanja (IZ) od 0,72 do 0,97, p = 0,014).
English: Steady state is rapidly achieved (within 4 to 5 days) during repeated oral administration (bid regimen).
Slovenian: Med ponavljajočo se peroralno uporabo (shema dvakrat na dan) je stanje dinamičnega ravnovesja doseženo hitro (v 4 do 5 dneh).
English: If you do accidentally take any of these drying agent tablets, they should not harm you but you should straight away talk to your doctor.
Slovenian: Če pomotoma vzamete katero od tablet sušila, vam ne bi smela škodovati,
English: • Hypovolaemia
Slovenian: • Hipovolemija.
English: The IONA study was a randomised, double blind, placebo controlled study carried out in 5126 patients more than 45 years old with chronic stable angina, treated with standard antianginal therapies and at high risk of cardiovascular events defined by either: 1) previous myocardial infarction, or 2) coronary artery bypass grafting , or 3) coronary artery disease confirmed by angiography, or a positive exercise test in the previous two years, together with one of the following: left ventricular hypertrophy on the ECG, left ventricular ejection fraction ≤45%, or an end diastolic dimension of >55 mm, age
Slovenian: starejših od 45 let, s kronično stabilno angino pektoris, zdravljenih s standardnim antianginoznim zdravljenjem, ki so imeli veliko tveganje za srčno-žilne dogodke glede na: (1) predhoden miokardni infarkt ali (2) obvodno operacijo koronarnih arterij ali (3) angiografsko potrjeno bolezen koronarnih arterij ali pozitiven izvid obremenitvenega testiranja v predhodnih dveh letih, ob tem pa še eno od naslednjega:
English: In patients concomitantly receiving NSAIDs including acetylsalicylic acid for both cardiovascular prevention and anti-inflammatory doses, there is an increased risk for severe complications such as gastrointestinal ulceration, perforation and haemorrhage (see section 4.4).
Slovenian: Pri bolnikih, ki sočasno prejemajo NSAID, vključno z acetilsalicilno kislino, za srčno-žilno preventivo in v protivnetnih odmerkih, obstaja večje tveganje za hude zaplete, na primer razjede na prebavilih, perforacijo prebavil in krvavitve v prebavila (glejte poglavje 4.4).
English: Therefore, caution is advised when concomitant use of corticosteroids is considered.
Slovenian: Zato je v primeru razmisleka o sočasni uporabi kortikosteroidov potrebna previdnost.
English: PHARMACEUTICAL FORM [To be completed nationally]
Slovenian: NAČIN IZDAJANJA ZDRAVILA [Izpolni država članica]
English: Special patient groups
Slovenian: Starejši bolniki
English: Each tablet contains 20 mg nicorandil.
Slovenian: Ena tableta vsebuje 20 mg nikorandila.
English: • Red, itchy, swollen or watery eyes (conjunctivitis)
Slovenian: • Pordele, srbeče, otekle oči ali solzenje oči (konjunktivitis)
English: - Gastrointestinal ulcerations Nicorandil induced ulceration may occur at different locations in the same patient.
Slovenian: Z nikorandilom povzročene razjede se lahko pri istem bolniku pojavijo na različnih mestih.
English: Based on available information, the time between starting nicorandil use and the onset of ulceration ranges from shortly after initiating nicorandil treatment to several years after starting nicorandil.
Slovenian: Glede na dostopne podatke se lahko razjede pojavijo kmalu po začetku uporabe nikorandila pa vse do več let po uvedbi zdravljenja.
English: A lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache.
Slovenian: Pri bolnikih, ki so nagnjeni h glavobolom, je mogoče uporabiti manjši začetni odmerek 5 mg dvakrat na dan.
English: • Medicines that widen the blood vessels.
Slovenian: • zdravila, ki širijo žile.
English: Due to its nitrate moiety, nicorandil relaxes also vascular smooth muscle, particularly in the venous system via an increase in intracellular cyclic guanosine monophosphate (cGMP).
Slovenian: Zaradi svoje nitratne skupine nikorandil preko zvišanja znotrajceličnega cikličnega gvanozinmonofosfata (cGMP) sprosti žilne gladke mišice, zlasti v venskem sistemu.
English: <Invented name> has an influence on the ability to drive and use machines.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji Zdravilo <Izmišljeno ime> vpliva na sposobnost vožnje in upravljanja s stroji.
English: • a rapid phase with a half-life of 1 hour approximately, representing 96% of the plasma exposure;
Slovenian: - v hitri fazi z razpolovnim časom približno 1 uro, ki predstavlja 96 % izpostavljenost v plazmi, - v počasni fazi izločanja, ki se pojavi približno 12 ur po uporabi 20 mg peroralno dvakrat na dan.
English: In addition, the activation of the potassium channel leads to cardioprotective effects mimicking ischemic pre-conditioning.
Slovenian: Poleg tega ima aktiviranje kalijevih kanalčkov zaščiten učinek na srce s posnemanjem ishemičnega prekondicioniranja.
English: • Nicorandil may cause injuries to your gastrointestinal tract such as ulcers.
Slovenian: • Nikorandil lahko povzroči poškodbo v prebavilih, na primer razjede.
English: This results in an increased pooling in capacitance vessels with a decrease in preload.
Slovenian: To povzroči kopičenje v kapacitivnih žilah in zmanjšanje predobremenitve ("preload").
English: How to take <Invented name>
Slovenian: Kako jemati zdravilo <Izmišljeno ime>
English: Do not take <Invented name>: • if you are allergic to nicorandil or any of the other ingredients of this medicine (listed in section
Slovenian: • če ste alergični na nikorandil ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Caution is advised when nicorandil is used in combination with other medical products that may increase potassium levels (see sections 4.4 and 4.8).
Slovenian: Previdnost je potrebna v primeru uporabe nikorandila v kombinaciji z drugimi zdravili, ki lahko povečajo koncentracijo kalija (glejte poglavje 4.4 in 4.8).