FrancophonIA/ELRC3.0 huggingface dataset:
English: It is not recommended to use Possia if you are pregnant or may become pregnant.
Danish: Det frarådes at bruge Possia hvis du er gravid eller kan blive gravid.
English: Uric acid increase
Danish: Forhøjet urinsyre
English: Uric acid elevations: In PLATO, serum uric acid concentration increased to more than upper limit of normal in 22% of patients receiving ticagrelor compared to 13% of patients receiving clopidogrel.
Danish: Forhøjet urinsyre: I PLATO steg serum-urinsyre-koncentrationen til mere end den øvre normalgrænse hos 22 % af de patienter, der fik ticagrelor, sammenlignet med 13 % af de patienter, der fik clopidogrel.
English: • the clot can cut off the blood supply completely - this can cause a heart attack (myocardial
Danish: • Blodproppen kan afskære blodforsyningen fuldstændigt - dette kan resultere i en blodprop i hjertet (myokardieinfarkt) eller et slagtilfælde (apopleksi).
English: Mean serum uric acid concentration increased approximately 15% with ticagrelor compared to approximately 7.5% with clopidogrel and after treatment was stopped, decreased to approximately 7% on ticagrelor but with no decrease observed for clopidogrel.
Danish: Den gennemsnitlige urinsyrekoncentration steg ca. 15 % på ticagrelor sammenlignet med ca. 7,5 % på clopidogrel, og faldt efter behandlingen blev stoppet til ca. 7 % på ticagrelor, mens der ikke blev set noget fald for clopidogrel.
English: In patients with stable coronary artery disease on ASA, ticagrelor demonstrates a rapid onset of pharmacological effect as demonstrated by a mean Inhibition of Platelet Aggregation (IPA) for ticagrelor at 0.5 hours after 180 mg loading dose of about 41%, with the maximum IPA effect of 89% by 2-4 hours post dose, and maintained between 2-8 hours.
Danish: Hos patienter med stabil koronararteriesygdom i ASA-behandling udviste ticagrelor en hurtigt indsættende farmakologisk virkning, hvilket blev påvist ud fra en gennemsnitlig IPA (Inhibition of Platelet Aggregation) for ticagrelor på omkring 41 % 0,5 time efter en 180 mg mætningsdosis , en maksimal IPA- på 89 % 2 til 4 timer efter dosering, -denne blev fastholdt i 2-8 timer.
English: Your doctor may want you to stop taking Possia 7
Danish: Din læge vil muligvis have dig til at stoppe
English: • You have moderate to severe liver disease
Danish: • hvis du lider af en moderat til svær leversygdom
English: Non-CABG PLATO Major bleeding was increased with ticagrelor compared clopidogrel in patients with one or more CYP2C19 loss of function alleles, but similar to clopidogrel in patients with no loss of function allele.
Danish: Der sås en øgning i non-CABG PLATO Major Bleeding med ticagrelor sammenlignet med clopidogrel hos patienter med en eller flere CYP2C19-alleler med nedsat funktion, men på samme niveau som clopidogrel hos patienter uden alleler med funktionstab.
English: There was no effect of simvastatin on ticagrelor plasma levels.
Danish: Simvastatin havde ingen indvirkning på ticagrelor-plasmaniveauerne.
English: Table 1 - Adverse reactions by frequency and System Organ Class (SOC)
Danish: Tabel 1 Bivirkninger, efter hyppighed og systemorganklasse Almindelige
English: • Feeling short of breath - this is common.
Danish: • Forpustet/stakåndethed - denne bivirkning er almindelig.
English: The frequency of possible side effects listed below is defined using the following convention: common (affects 1 to 10 users in 100); uncommon (affects 1 to 10 users in 1,000); rare (affects 1 to 10
Danish: Hyppigheden af de mulige bivirkninger, som er anført nedenfor, defineres som følger: almindelig (forekommer hos mellem 1 og 10 ud af 100 patienter), ikke almindelig (forekommer hos mellem 1 og 10 ud af 1.000 patienter), sjælden (forekommer hos mellem 1 og 10 ud af 10.000 patienter).
English: • You have had a blood test that showed more than the usual amount of uric acid
Danish: • hvis du har fået taget en blodprøve, der viste, at du har en højere mængde urinsyre i blodet en
English: Exposure to ticagrelor and the active metabolite were approximately 20% lower in patients with severe renal impairment (creatinine clearance <30 ml/min) compared to subjects with normal renal function
Danish: Eksponeringen for ticagrelor og den aktive metabolit var ca. 20 % lavere hos patienter med svært nedsat nyrefunktion (kreatininclearance < 30 ml/min) sammenlignet med forsøgspersoner med normal nyrefunktion (se pkt.
English: The use of Possia is contraindicated in patients with active pathological bleeding, in those with a history of intracranial haemorrhage, and in patients with moderate to severe hepatic impairment (see section 4.3).
Danish: Brugen af Possia er kontraindiceret hos patienter med aktiv patologisk blødning, hos patienter med intrakraniel blødning i anamnesen og hos patienter med moderat til svært nedsat leverfunktion (se pkt.
English: Therefore, premature discontinuation of treatment
Danish: Præmatur seponering af behandling skal derfor undgås.
English: The major metabolite of ticagrelor is AR-C124910XX, which is also active as assessed by in vitro binding to the platelet P2Y12 ADP-receptor.
Danish: Ticagrelors vigtigste metabolit er AR-C124910XX, som også er aktiv vurderet ud fra in vitro-binding til trombocyt P2Y12 ADP-receptoren.
English: Co-administration of rifampicin with ticagrelor decreased ticagrelor Cmax and AUC by 73% and 86%, respectively.
Danish: Samtidig administration af rifampicin og ticagrelor reducerede ticagrelors Cmax og AUC med hhv. 73 % og 86 %.
English: Since co-administration of Possia with desmopressin did not decrease template-bleeding time, desmopressin is unlikely to be effective in managing clinical bleeding events (see section 4.5).
Danish: Da samtidig administration af Possia og desmopressin ikke reducerede den normale (standardiserede) blødningstid, er det usandsynligt at desmopressin vil være effektivt til behandling af kliniske blødningshændelser (se pkt.
English: On a background of daily ASA, ticagrelor 90 mg twice daily showed superiority to 75 mg daily clopidogrel in preventing the composite endpoint of cardiovascular [CV] death, myocardial infarction [MI], or stroke, with the difference driven by CV death and MI.
Danish: Baseret på dagligt brug af ASA viste ticagrelor 90 mg to gange dagligt sig at være bedre end clopidogrel 75 mg dagligt til at forebygge det sammensatte endepunkt (kardiovaskulære [CV] dødsfald, myokardieinfarkt [MI] eller slagtilfælde), hvor forskellen var forårsaget af CV-dødsfald og MI.
English: Possia helps stop the clumping of platelets.
Danish: Possia forhindrer sammenklumpningen af blodpladerne.
English: These differences are not considered clinically significant (see section 4.2).
Danish: Disse forskelle anses ikke for klinisk signifikante (se pkt.
English: • Co-administration of ticagrelor with strong CYP3A4 inhibitors (e.g., ketoconazole,
Danish: • Samtidig administration af ticagrelor og stærke CYP3A4-hæmmere (f.eks. ketoconazol,
English: No studies on the effects of Possia on the ability to drive and use machines have been performed.
Danish: Der er ikke foretaget undersøgelser af virkningen på evnen til at føre motorkøretøj eller betjene maskiner.
English: Possia (%/year) N=9235
Danish: Possia (% patienter med hændelse) N=9333
English: Possia and clopidogrel did not differ in rates of PLATO Major Fatal/Life-threatening bleeding, PLATO total Major bleeding, TIMI Major bleeding, or TIMI Minor bleeding (Table 2).
Danish: Possia og clopidogrel adskilte sig ikke med hensyn til hyppighed af PLATO Major Fatal/Lifethreatening bleeding, PLATO total Major bleeding, TIMI Major bleeding eller TIMI Minor bleeding (Tabel 2).
English: Patients can be switched from clopidogrel to ticagrelor without any interruption of antiplatelet effect (see section 4.2).
Danish: Patienter kan skiftes fra clopidogrel til ticagrelor, uden at hæmningen af trombocytfunktionen afbrydes (se pkt.
English: Higher exposures to ticagrelor (approximately 25% for both Cmax and AUC) and the active metabolite were observed in elderly (≥ 75years) ACS patients compared to younger patients by the population pharmacokinetic analysis.
Danish: Der sås højere eksponeringer for ticagrelor (ca. 25 % for både Cmax og AUC) og den aktive metabolit hos ældre forsøgspersoner (≥75 år) AKS-patienter sammenlignet med yngre forsøgspersoner.
English: In 2.2% of patients taking ticagrelor and by 0.6% taking clopidogrel investigators considered the dyspnoea causally related to treatment in the PLATO study and few were serious (0.14% ticagrelor; 0.02% clopidogrel), (see section 4.4).
Danish: Hos 2,2 % af de patienter, der tog ticagrelor og hos 0,6 % af dem, der tog clopidogrel, vurderede investigatorerne i PLATO-studiet, at dypsnøen var kausalt relateret til behandlingen , og få var alvorlige (0,14 % ticagrelor; 0,02 % clopidogrel) (se pkt.
English: Possia treatment should be initiated with a single 180 mg loading dose (two tablets of 90 mg) and then
Danish: Possia-behandling skal indledes med en enkelt 180 mg mætningsdosis (to tabletter på hver 90 mg) og derefter fortsættes med 90 mg to gange dagligt.
English: Ticagrelor is primarily a CYP3A4 substrate and a mild inhibitor of CYP3A4.
Danish: Ticagrelor er primært et CYP3A4-substrat og en mild hæmmer af CYP3A4.
English: There were no adverse clinical consequences associated with this imbalance (including syncope or pacemaker insertion) in this patient population (see section 5.1).
Danish: Der sås ingen uønskede kliniske konsekvenser forbundet med disse forstyrrelser (inklusive synkope eller indsættelse af pacemaker) hos denne patientpopulation (se pkt.
English: All-cause mortality d
Danish: Mortalitet uanset årsag
English: No data exist with Possia regarding a haemostatic benefit of platelet transfusions; circulating Possia may inhibit transfused platelets.
Danish: Der foreligger ingen data for Possia angående et hæmostatisk udbytte af trombocyttransfusioner; cirkulerende Possia kan hæmme de transfunderede trombocytter.
English: Medicinal products metabolised by CYP3A4
Danish: Lægemidler der metaboliseres af CYP3A4
English: AstraZeneca UK Limited Silk Road Business Park
Danish: AstraZeneca UK Limited Silk Road Business Park Macclesfield, Cheshire, SK10 2NA Storbritannien
English: Rare (affects 1 to 10 users in 10,000)
Danish: Sjældne (forekommer hos mellem 1 og 10 ud af 10.000 patienter)
English: • History of intracranial haemorrhage (see section 4.8).
Danish: • Intrakraniel blødning i anamnesen (se pkt.
English: • Atorvastatin - Co-administration of atorvastatin and ticagrelor increased atorvastatin acid Cmax by 23% and AUC by 36%.
Danish: • Atorvastatin - Samtidig administration af atorvastatin og ticagrelor øgede atorvastatinsyrens Cmax med 23 % og AUC med 36 %.
English: The PLATO study included 18,624 patients who presented within 24 hours of onset of symptoms of unstable angina (UA), non ST elevation myocardial infarction (NSTEMI) or ST elevation myocardial infarction (STEMI), and were initially managed medically, or with percutaneous coronary intervention (PCI), or with coronary artery bypass grafting (CABG) (see section 4.1).
Danish: PLATO-studiet omfattede 18.624 patienter, som henvendte sig inden for 24 timer efter debut af symptomer på ustabil angina (UA), non-ST-elevationsmyokardieinfarkt (NSTEMI) eller STelevationsmyokardieinfarkt (STEMI), og som indledningsvist blev behandlet med medicin eller med perkutan koronar intervention (PCI) eller med koronar bypassoperation (CABG) (se pkt.
English: EU/1/10/656/002 180 film-coated tablets
Danish: EU/1/10/656/001-006
English: Ticagrelor is orally active, and reversibly interacts with the platelet P2Y12 ADP-receptor.
Danish: Ticagrelor er oralt aktivt og interagerer reversibelt med trombocyt P2Y12 ADP-receptoren.
English: Medinfar Produtos Farmacêuticos, S.A. Tel: + 351 21 499 74 00
Danish: Medinfar Produtos Farmaceuticos, S.A. Tel: + 351 21 4997400
English: • rifampicin (an antibiotic), phenytoin, carbamazepine and phenobarbital (used to control seizures), dexamethasone (used to treat inflammatory and auto immune conditions), digoxin (used to treat heart failure), cyclosporin (used to lessen your body's defenses), quinidine and diltiazem (used to treat abnormal heart rhythms), beta blockers and verapamil (used to treat high
Danish: • rifampicin (et antibiotikum), phenytoin, carbamazepin og phenobarbital (anvendes til at kontrollere anfald), dexamethason (til behandling af betændelsestilstande og autoimmune tilstande), digoxin (til behandling af hjertesvigt), ciclosporin (anvendes til at nedsætte din krops forsvarssystem), quinidin og diltiazem (til behandling af unormal hjerterytme), betablokkere og verapamil (til behandling af forhøjet blodtryk).
English: Pharmacotherapeutic group: Platelet aggregation inhibitors excluding heparin, ATC code: B01AC24
Danish: heparin, ATC-kode: B01AC24
English: The most commonly reported adverse reactions in patients treated with ticagrelor were dyspnoea, contusion and epistaxis and these reactions occurred at higher rates than in the clopidogrel treatment group.
Danish: De mest almindeligt rapporterede bivirkninger hos de patienter, der blev behandlet med ticagrelor, var dyspnø, kutane blødninger og næseblod, og disse bivirkninger forekom med større hyppighed end i clopidogrel-behandlingsgruppen.
English: Other CYP3A inducers (e.g. dexamethasone, phenytoin, carbamazepine and phenobarbital) would be expected to decrease the exposure to Possia as well.
Danish: CYP3A-induktorer (f.eks. dexamethason, phenytoin, carbamazepin og phenobarbital) forventes også at reducere eksponeringen for Possia.
English: If the association cannot be avoided, their concomitant use should be made with caution (see section 4.5).
Danish: Hvis samtidig anvendelse ikke kan undgås, tilrådes forsigtighed (se pkt.4.5).
English: Ticagrelor does not interact with the ADP binding site itself, but interacts with platelet P2Y12 ADP-receptor to prevent signal
Danish: Ticagrelor interagerer ikke på selve ADP-bindingsstedet, men interagerer med trombocyt P2Y12 ADP-receptoren og forhindrer herigennem signaltransduktion.
English: During the Holter substudy in PLATO, more patients had ventricular pauses >3 seconds with ticagrelor than with clopidogrel during the acute phase of their ACS.
Danish: Et Holter-monitorerings-substudie i PLATO viste, at flere patienter havde ventrikulære pauser >3 sekunder med ticagrelor end med clopidogrel i den akutte fase af deres akutte koronare syndrom (AKS).
English: Pharmacokinetic studies performed with radio-labeled ticagrelor have shown that the parent compound and its metabolites are excreted in the milk of rats (see section 4.6).
Danish: Farmakokinetikstudier, der blev foretaget med radioaktivt mærket ticagrelor, har vist, at stamstoffet og dets metabolitter udskilles i mælken hos rotter (se pkt.
English: Ticagrelor is a mild CYP3A4 inhibitor.
Danish: Ticagrelor er en mild CYP3A4-hæmmer.
English: Due to observations of mostly asymptomatic ventricular pauses and bradycardia, caution should be exercised when administering Possia concomitantly with medicinal products known to induce bradycardia (see section 4.4).
Danish: På grund af observationer af hovedsagelig asymptomatiske ventrikulære pauser og bradykardi bør der udvises forsigtighed i forbindelse med samtidig administration af Possia og lægemidler, der vides at inducere bradykardi (se pkt.
English: Possia affects cells called ‘platelets' (also called thrombocytes).
Danish: Possia påvirker celler, der kaldes ”blodplader” eller ”trombocytter”.
English: TIMI Minor Bleed: Clinically apparent with 30-50 g/l decrease in haemoglobin.
Danish: TIMI Minor Bleed: Klinisk åbenbar med en reduktion på 30-50 g/l af hæmoglobin.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of ticagrelor and its active metabolites in milk (see section 5.3).
Danish: De tilgængelige farmakodynamiske/toksikologiske data fra dyreforsøg viser, at ticagrelor og dets aktive metabolitter udskilles i mælk (se pkt.
English: No data are available (see section 5.1 and 5.2).
Danish: 5.1 og 5.2).
English: Possia, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with Acute Coronary Syndromes (unstable angina, non ST elevation Myocardial Infarction [NSTEMI] or ST elevation Myocardial Infarction [STEMI]); including patients managed medically, and those who are managed with percutaneous coronary intervention (PCI) or coronary artery by-pass grafting (CABG).
Danish: Possia, der administreres sammen med acetylsalicylsyre (ASA), er indiceret til forebyggelse af aterotrombotiske hændelser hos voksne patienter med akut koronarsyndrom (ustabil angina, non-STelevationsmyokardieinfarkt [NSTEMI] eller ST-elevationsmyokardieinfarkt [STEMI]), herunder medicinsk behandlede patienter og patienter behandlet med perkutan koronar intervention (PCI) eller koronar bypassoperation (CABG).
English: The expected effect of excessive Possia dosing is prolonged duration of bleeding risk associated with platelet inhibition.
Danish: Den forventede virkning af for høj dosering med Possia er, at den blødningsrisiko, der er forbundet med trombocythæmning, vil vare længere.
English: Ticagrelor should be used with caution in patients with history of asthma and/or COPD.
Danish: Ticagrelor bør anvendes med forsigtighed hos patienter med en anamnese med astma og/eller KOL.
English: Non-CABG related bleeding and non-procedural related bleeding: Possia and clopidogrel did not differ in non-CABG PLATO-defined Major Fatal/Life-threatening bleeding, but PLATO-defined Total Major, TIMI Major, and TIMI Major + Minor bleeding were more common with ticagrelor.
Danish: Ikke koronar-bypass (non-CABG)-relateret blødning og ikke-procedurerelateret blødning: Der var ingen forskel Possia og clopidogrel imellem mht. non-CABG PLATO-defineret Major Fatal/Lifethreatening bleeding, mens PLATO-defineret Total Major, TIMI Major og TIMI Major + Minor bleeding var mere almindelige med ticagrelor.
English: There was no effect of ticagrelor on diltiazem plasma levels.
Danish: Ticagrelor havde ingen indvirkning på diltiazem-plasmaniveauerne.
English: • selective serotonin reuptake inhibitors (abbreviated as SSRIs) taken as antidepressants such as paroxetine, sertraline and citalopram
Danish: • selektive serotoningenoptagelseshæmmere (forkortet SSRI), der tages mod depression, såsom paroxetin, sertralin og citalopram.
English: If you take more Possia than you should, talk to a doctor or go to hospital straight away.
Danish: Hvis du har taget for mange Possia, skal du straks kontakte din læge eller tage på sygehuset.
English: Due to reports of cutaneous bleeding abnormalities with SSRIs (e.g., paroxetine, sertraline and citalopram), caution is advised when administering SSRIs with Possia as this may increase the risk of
Danish: På grund af rapporter om kutane blødningsabnormiteter i forbindelse med SSRI (f.eks. paroxetin, sertralin og citalopram) rådes til forsigtighed ved samtidig administration af SSRI og Possia, da dette kan øge risikoen for blødning.
English: • After this starting dose, the usual dose is one tablet of 90 mg twice a day for up to 12 months unless your doctor tells you differently.
Danish: • Efter denne startdosis er den sædvanlige dosis én tablet (90 mg) to gange dagligt i op til
English: Cmax and AUC for ticagrelor were 12% and 23% higher in patients with mild hepatic impairment compared to matched healthy subjects, respectively (see section 4.2).
Danish: Cmax og AUC for ticagrelor var hhv. 12 % og 23 % højere hos patienter med mildt nedsat leverfunktion sammenlignet med tilsvarende raske forsøgspersoner (se pkt.
English: No dose adjustment is necessary for patients with mild hepatic impairment.
Danish: Dosisjustering er ikke nødvendig for patienter med let nedsat leverfunktion.
English: Co-administration of Possia with heparin, enoxaparin or desmopressin had no effect on activated partial thromboplastin time (aPTT), activated coagulation time (ACT) or factor Xa assays.
Danish: Samtidig administration af Possia og heparin, enoxaparin eller desmopressin påvirkede ikke Paktiveret partiel tromboplastintid (aPTT), aktiveret koagulationstid eller faktor Xa-analyser.
English: Do not throw away any medicinesvia wastewater or household waste.
Danish: Af hensyn til miljøet må du ikke smide medicinrester i afløbet, toilettet eller skraldespanden.
English: Other moderate CYP3A4 inhibitors (e.g. amprenavir, aprepitant, erythromycin and fluconazole) would be expected to have a similar effect and can as well be co-administered with Possia.
Danish: Andre moderate CYP3A4-hæmmere (f.eks. amprenavir, aprepitant, erythromycin og fluconazol) forventes at have en lignende virkning og kan også administreres samtidig med Possia.
English: 90% of patients had final extent IPA
Danish: 90 % af patienterne havde en endelig påvirkning af IPA på >70 % 2 timer efter dosering.
English: Creatinine elevations: In PLATO, serum creatinine concentration significantly increased by >30% in 25.5% of patients receiving ticagrelor compared to 21.3% of patients receiving clopidogrel and by >50% in 8.3% of patients receiving ticagrelor compared to 6.7% of patients receiving clopidogrel.
Danish: Forhøjet kreatinin: I PLATO steg serum-kreatininkoncentrationen med >30 % hos 25,5 % af de patienter, der fik ticagrelor, sammenlignet med 21,3 % af de patienter, der fik clopidogrel, og med >50 % hos 8,3 % af de patienter, der fik ticagrelor, sammenlignet med 6,7 % af dem, der fik clopidogrel.
English: Ticagrelor has not been studied in patients with moderate or severe hepatic impairment and its use in these patients is contraindicated
Danish: Ticagrelor er ikke blevet undersøgt hos patienter med moderat til svært nedsat leverfunktion, og brugen af ticagrelor hos disse patienter er kontraindiceret (se pkt.
English: In PLATO study, patients on ticagrelor had a higher risk of hyperuricaemia than those patients receiving clopidogrel (see section 4.8).
Danish: I PLATO-studiet havde patienter, der fik ticagrelor, en højere risiko for hyperurikæmi, end patienter der fik clopidogrel (se pkt.
English: Women of childbearing potential should use appropriate contraceptive measures to avoid pregnancy
Danish: Kvinder i den fertile alder skal anvende sikker kontraception under behandlingen med Possia for at undgå graviditet.
English: TIMI Major Bleed: Clinically apparent with >50 g/l decrease in haemoglobin or intracranial haemorrhage.
Danish: TIMI Major Bleed: Klinisk åbenbar med en reduktion på >50 g/l af hæmoglobin eller intrakraniel blødning.
English: Ticagrelor should be used with caution in patients with history of asthma and/or COPD (see section 4.4).
Danish: Ticagrelor bør anvendes med forsigtighed hos patienter med en anamnese med astma og/eller COPD (se pkt.
English: If your feeling of shortness of breath gets worse or lasts a long time, tell your doctor.
Danish: Hvis din fornemmelse af at være stakåndet forværres eller varer længe, skal du fortælle din læge det. Din læge vil afgøre, om det skal behandles eller undersøges yderligere.
English: Common (affects 1 to 10 users in 100) • Bruising
Danish: Almindelige (forekommer hos mellem 1 og 10 ud af 100 patienter): • Blå mærker
English: These very small blood cells help stop bleeding by clumping together to plug tiny holes in blood vessels that are cut or damaged.
Danish: De medvirker til at stoppe blødninger ved at klumpe sammen, så de kan tilstoppe bittesmå flænger eller skader på blodkar.
English: Tablet core: mannitol (E421), dibasic calcium phosphate, sodium starch glycolate, hydroxypropyl-cellulose (E463), magnesium stearate (E470b)
Danish: • Øvrige indholdsstoffer: Tabletkerne: mannitol (E421), dibasisk kalciumfosfat, natriumstivelsesglycolat, hydroxypropylcellulose (E463), magnesiumstearat (E470b).
English: A. MANUFACTURER(S) RESPONSIBLE FOR BATCH
Danish: FREMSTILLER(E) ANSVARLIG(E) FOR BATCHFRIGIVELSE
English: • Strong CYP3A4 inhibitors - Co-administration of ketoconazole with ticagrelor increased the ticagrelor Cmax and AUC equal to 2.4-fold and 7.3-fold, respectively.
Danish: • Stærke CYP3A4-hæmmere - Samtidige administration af ketoconazol og ticagrelor øgede ticagrelors Cmax og AUC svarende til hhv. 2,4 gange og 7,3 gange.