FrancophonIA/ELRC3.0 huggingface dataset:
English: When administration of rosuvastatin and boosted darunavir is required, it is recommended to start with the lowest possible dose of rosuvastatin and titrate up to the desired clinical effect while monitoring for safety.
Slovenian: Če je potrebna sočasna uporaba rosuvastatina in okrepljenega darunavirja, je priporočljivo, da zdravljenje začnete z najnižjim možnim odmerkom rosuvastatina, ki ga nato, ob spremljanju varnosti,
English: ethinylestradiol AUC  30% ethinylestradiol Cmin ND
Slovenian: amitriptilin dezipramin imipramin nortriptilin trazodon
English: Alternative or additional contraceptive measures are recommended when oestrogen-based contraceptives are co-administered with darunavir and low dose ritonavir.
Slovenian: Pri sočasni uporabi estrogenskih kontraceptivov in darunavirja z majhnim odmerkom ritonavirja je priporočljiva uporaba alternativnih ali dodatnihkontracepcijskih metod.
English: if treatment with darunavir coadministered with low dose ritonavir is required.
Slovenian: Pri kombiniranju teh zdravil proti raku z darunavirjem skupaj z majhnim odmerkom ritonavirja je potrebna previdnost.
English: effects.
Slovenian: omotični.
English: You will require a different dose of Darunavir Krka d.d.
Slovenian: - Zvečer vzemite eno tableto zdravila Darunavir Krka d.d.
English: Cmax, ng/ml
Slovenian: RNK (kopij/ml)
English: In most cases, Darunavir Krka d.d.
Slovenian: Večinoma se zdravilo Darunavir Krka d.d.
English: The concomitant use with boosted darunavir may require to lower the dose of alfentanil and requires monitoring for risks of prolonged or delayed respiratory depression.
Slovenian: Bolnike je treba spremljati zaradi tveganja za dolgotrajnoali zakasnjeno depresijo dihanja
English: Ritonavir inhibits the transporters P-glycoprotein, OATP1B1 and OATP1B3, and co-administration with substrates of these transporters can result in increased plasma concentrations of these compounds (e.g. dabigatran etexilate, digoxin, statins and bosentan; see the Interaction table below).
Slovenian: Sočasna uporaba s substrati teh prenašalcev lahko povzroči zvišanje plazemskih koncentracij teh učinkovin (npr. dabigatraneteksilat, digoksin, statini in bosentan; glejte spodnjo preglednico medsebojnih delovanj z drugimi zdravili).
English: Do not combine Darunavir Krka d.d.
Slovenian: Brez ritonavirja zdravilo Darunavir Krka d.d.
English: Uncommon side effects (may affect up to 1 in 100 people) chest pain, changes in electrocardiogram, rapid heart beating decreased or abnormal skin sensibility, pins and needles, attention disturbance, loss of memory, problems with your balance difficulty breathing, cough, nosebleed, throat irritation inflammation of the stomach or mouth, heartburn, retching, dry mouth, discomfort of the abdomen, constipation, belching kidney failure, kidney stones, difficult dischargeof urine, frequent or excessive passage of urine, sometimes at night urticaria, severe swelling of the skin and other tissues (most often the lips or the eyes), eczema, excessive sweating, night sweats, hair loss, acne, scaly skin, colouration of nails muscle pain, muscle cramps or weakness, pain in extremity, osteoporosis slowing down of the thyroid gland function.
Slovenian: Občasni neželeni učinki (pojavijo se lahko pri največ 1 od 100 bolnikov) - bolečine v prsih, spremembe elektrokardiograma, hitro bitje srca - zmanjšana ali nenavadna občutljivost kože, zbadanje, motnje pozornosti, izguba spomina, težave z ravnotežjem - težave z dihanjem, kašelj, krvavenje iz nosu, draženje grla - vnetje želodca ali ust, zgaga, siljenje na bruhanje, suha usta, bolečina v trebuhu,
English: 120 (3x40) capsules
Slovenian: 120 (3x40) kapsul
English: Dr Robert James Hemmings (United Kingdom)
Slovenian: dr. Robert James Hemmings (Združeno Kraljestvo)
English: Article 29 of Directive 2001/83/EC as amended, referral on the grounds of potential serious risk to public health
Slovenian: Člen 29 Direktive 2001/83/ES, kakor je spremenjena, napotitev zaradi morebitnih resnih tveganj za javno zdravje.
English: Ref. EMEA/CHMP/734798/2009 rev. EMEA/H/A-29/1169
Slovenian: EMEA/CHMP/734798/2009 rev. EMEA/H/A-29/1169
English: This is a procedure when one Member State (the ‘reference Member State', in this instance the UK) assesses a medicine with a view of granting a marketing authorisation that will be valid in this country as well as in other member states (the ‘concerned Member States', in this instance the Czech Republic, Germany, Poland and Slovakia).
Slovenian: To je postopek, pri katerem ena od držav članic („referenčna država članica“, v tem primeru Združeno kraljestvo) oceni zdravilo z namenom odobritve dovoljenja za promet z njim, ki bo veljavno v tej državi in v drugih državah članicah (v „zadevnih državah članicah“, v tem primeru v Češki republiki, Nemčiji, na Poljskem in Slovaškem).
English: Bioequivalnce studies are used to compare how a generic medicine is absorbed by the body in comparison to the reference medicine.
Slovenian: Študije biološke enakovrednosti se uporabljajo za primerjavo načina, kako telo absorbira generično zdravilo v primerjavi z referenčnim zdravilom.
English: Questions and answers on the referral for Pantoprazole Olinka pantoprazole 20 and 40 mg tablets
Slovenian: Vprašanja in odgovori v zvezi z napotitvenim postopkom za zdravilo Pantoprazole Olinka pantoprazol 20 in 40 mg tablete
English: However, the member states were not able to reach an agreement and the UK medicines regulatory agency referred the matter to the CHMP for arbitration on 30 April 2009.
Slovenian: Ker pa omenjene države članice niso dosegle soglasja, je britanska regulativna agencija za zdravila dne 30. aprila 2009 zadevo napotila na CHMP v arbitražo.
English: The European Medicines Agency has completed an arbitration procedure following a disagreement among Member States of the European Union regarding the authorisation of the medicine Pantoprazole Olinka.
Slovenian: Evropska agencija za zdravila je končala postopek arbitraže, do katerega je prišlo po nesoglasju med državami članicami Evropske unije glede odobritve zdravila Pantoprazole Olinka.
English: It works by blocking ‘proton pumps', proteins found in specialised cells in the stomach lining that pump acid into the stomach.
Slovenian: Deluje tako, da zavira „protonske črpalke“, beljakovine v specializiranih celicah v želodčni sluznici, ki črpajo kislino v želodec.
English: Based on evaluation of the currently available data and the scientific discussion within the Committee, the CHMP concluded that Pantoprazole Olinka had been shown to be bioequivalent to the reference medicine, and therefore the marketing authorisation should be granted in the UK and all concerned member states.
Slovenian: Na podlagi ocene trenutno razpoložljivih podatkov in znanstvene razprave v odboru CHMP je ta zaključil, da se je zdravilo Pantoprazole Olinka izkazalo za biološko enakovredno referenčnemu zdravilu, zato se lahko odobri dovoljenje za promet z zdravilom v Združenem kraljestvu in v vseh zadevnih državah članicah.
English: The 20 mg tablets can be used for reflux disease to treat symptoms such as heartburns and acid regurgitation (acid flowing up in the mouth), for the long-term management and prevention of relapse in reflux oesophagitis (inflammation of the gullet, due to acid), for the prevention of the stomach ulcers that can be caused by some medicines used to treat pain and inflammations called non-selective non-steroidal anti-inflammatory drugs (NSAIDs), when the patient needs continuous NSAID treatment.
Slovenian: 2o-miligramske tablete se lahko uporabljajo za lajšanje simptomov refluksa, kot sta zgaga in regurgitacija kisline (vračanje kisline v usta), za dolgoročno zdravljenje in preprečevanje ponovne pojavitve refluksnega ezofagitisa (vnetje požiralnika zaradi kisline), za preprečevanje razjed na želodcu, ki jih lahko povzročajo nekatera zdravila za lajšanje bolečin in vnetij, imenovana neselektivna nesteroidna protivnetna zdravila (NSAID), kadar bolnik potrebuje stalno zdravljenje z NSAID.
English: The grounds for the referral were concerns expressed by the German medicines regulatory agency regarding the bioequivalence study comparing Pantoprazole Olinka and Pantecta.
Slovenian: Razlogi za napotitev so bili zadržki, ki jih je izrazila nemška regulativna agencija za zdravila glede študije biološke enakovrednosti, v kateri so primerjali zdravili Pantoprazole Olinka in Pantecta.
English: Olinka UK Ltd. submitted Pantoprazole Olinka to the United Kingdom medicines regulatory agency for a decentralised procedure.
Slovenian: Družba Olinka UK Ltd. je zdravilo Pantoprazole Olinka predložila britanski regulativni agenciji za zdravila v decentraliziran postopek.
English: Pantoprazole Olinka is a medicine used to treat diseases where the stomach produces too much acid.
Slovenian: Pantoprazole Olinka je zdravilo, ki se uporablja za zdravljenje bolezni, pri katerih želodec tvori preveč kisline.
English: By blocking the pumps, pantoprazole reduces acid production.
Slovenian: Z zaviranjem črpalk pantoprazol zmanjša tvorbo kisline.
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) has concluded that the benefits of Pantoprazole Olinka outweigh its risks, and the marketing authorisation can be granted in the United Kingdom and in the following Member States of the European Union, the Czech Republic, Germany, Poland and Slovakia.
Slovenian: Odbor za zdravila za uporabo v humani medicini (CHMP) pri agenciji EMEA je zaključil, da koristi zdravila Pantoprazole Olinka odtehtajo njegova tveganja in da se lahko dovoljenje za promet z zdravilom odobri v Združenem kraljestvu ter tudi v naslednjih državah članicah Evropske unije: Češki republiki, Nemčiji, na Poljskem in Slovaškem.
English: The 40 mg tablets can be used for more severe acid diseases such as stomach ulcer, duodenal ulcer, Zollinger-Ellison syndrome (a condition caused by oversecretion of acid in the stomach) and to help rid the stomach of a bacterium called Helicobacter pylori, which is known to cause stomach ulcer.
Slovenian: 40 mg tablete se lahko uporabljajo za zdravljenje hujših obolenj zaradi kisline, kot so razjede na želodcu in dvanajstniku, Zollinger-Ellisonovega sindroma (stanja, ki nastane zaradi čezmernega izločanja kisline v želodcu) in za pomoč pri odstranitvi bakterije Helicobacter pylori iz želodca, za katero je znano,da povzroča razjedo na želodcu.
English: Pantoprozole Olinka is a generic medicine based on the reference medicine Pantecta.
Slovenian: Pantoprozole Olinka je generično zdravilo na osnovi referenčnega zdravila Pantecta.
English: Why was Pantoprazole Olinka reviewed?
Slovenian: Zakaj je bilo zdravilo Pantoprozole Olinka pregledano?
English: What is Pantoprazole Olinka?
Slovenian: Kaj je zdravilo Pantoprazole Olinka?
English: This prevents the active substance from being destroyed by the acid in the stomach.
Slovenian: Tako se prepreči, da bi želodčna kislina razgradila zdravilno učinkovino.
English: The active substance in Pantoprazole Olinka, pantoprazole, is a proton pump inhibitor.
Slovenian: Zdravilna učinkovina zdravila Pantoprazole Olinka, pantoprazol, je zaviralec protonske črpalke.
English: Pantoprazole Olinka is presented as gastro-resistant tablets.
Slovenian: Zdravilo Pantoprazole Olinka je na voljo v obliki gastrorezistentnih tablet.
English: Company responses provided on: 27 August 2009, 26 October 2009 Opinion date:
Slovenian: 27. avgust 2009, 26. oktober 2009
English: 3 years.
Slovenian: 3 roky.
English: • Risk Management Plan (RMP) Not applicable.
Slovenian: • Plán riadenia rizík (RMP) Neaplikovateľné.
English: You may also need other treatments.
Slovenian: Môžete tiež potrebovať iné liečby.
English: However, no unacceptable risks appear to be present in this patient group.
Slovenian: Nezdá sa však, že by v tejto skupine pacientov boli prítomné neprijateľné riziká.
English: Elderly patients (> 70 years of age)
Slovenian: Starší pacienti (> 70 rokov)
English: Keep the bottle tightly closed.
Slovenian: Fľašu udržiavajte dôkladne uzatvorenú.
English: - This medicine has been prescribed for you only.
Slovenian: • Tento liek bol predpísaný iba vám.
English: Supportive measures should be provided as necessary.
Slovenian: V prípade potreby sa majú vykonať podporné opatrenia.
English: • Periodic Safety Update Reports
Slovenian: • Periodicky aktualizované správy o bezpečnosti
English: Date of latest renewal: 18 July 2014
Slovenian: Dátum posledného predĺženia registrácie: 18. júl 2014.
English: In 43 patients stable disease was reported.
Slovenian: Stabilné ochorenie sa hlásilo u 43 pacientov.
English: Take the capsules on an empty stomach; for example, at least one hour before you plan to eat breakfast.
Slovenian: Kapsuly užívajte nalačno; napríklad najmenej 1 hodinu pred plánovanými raňajkami.
English: The following side effects may occur, and may require medical attention.
Slovenian: Nasledovné vedľajšie účinky sa môžu objaviť a môžu si vyžadovať lekársku pozornosť.
English: Errors in how you take this medicine may have serious health consequences.
Slovenian: Chyby v spôsobe užívania tohto lieku môžu zanechať vážne následky na vašom zdraví.
English: - which days are your dosing days.
Slovenian: • ktoré dni sú vaše dni liečby.
English: No data are available.
Slovenian: Nie sú k dispozícii žiadne údaje.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 25 January 2010
Slovenian: DÁTUM PRVEJ REGISTRÁCIE/ PREDĹŽENIA REGISTRÁCIE Dátum prvej registrácie: 25. január 2010.
English: Although the data is limited, tolerance in children is expected to be the same as in adults.
Slovenian: Hoci sú údaje obmedzené, očakáva sa, že znášanlivosť u detí bude rovnaká ako u dospelých.
English: Achieving a radiological objective response or maintaining progression-free status was strongly associated with maintained or improved quality of life.
Slovenian: Dosiahnutie rádiologicky objektívnej odpovede alebo udržania stavu bez progresie bolo silne viazané s udržanou alebo zlepšenou kvalitou života.
English: Ask your doctor or pharmacist to write it down (including the colour).
Slovenian: Požiadajte vášho lekára alebo lekárnika, aby vám to napísal (vrátane farby).
English: Capsules should not be opened.
Slovenian: Kapsuly sa nesmú otvárať.
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Slovenian: Vedľajšie účinky môžete hlásiť aj priamo prostredníctvom národného systému hlásenia uvedeného v Prílohe V. Hlásením vedľajších účinkov môžete prispieť k získaniu ďalších informácií o bezpečnosti tohto lieku.
English: In this case, your doctor will also prescribe medicine to help you prevent this type of pneumonia (PCP).
Slovenian: V tomto prípade vám váš lekár predpíše tiež liek, ktorý vám pomôže predísť zápalu pľúc (PCP) tohto typu.
English: The colour and marking of the capsule is different for each strength (see table below).
Slovenian: Farba a označenie vrchnáčika kapsuly je pre každú silu iná (pozri tabuľku nižšie).
English: Do not store above 30 °C.
Slovenian: Uchovávajte pri teplote neprevyšujúcej 30 °C.
English: Do not use this medicine after the expiry date which is stated on the label and carton.
Slovenian: Nepoužívajte tento liek po dátume exspirácie, ktorý je uvedený na štítku a škatuli.
English: Concomitant phase
Slovenian: Súbežná fáza
English: Each one lasts 28 days.
Slovenian: Každá trvá 28 dní.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Slovenian: Od zdravotníckych pracovníkov sa vyžaduje, aby hlásili akékoľvek podozrenia na nežiaduce reakcie prostredníctvom národného systému hlásenia uvedeného v Prílohe V.
English: Side effects from clinical studies:
Slovenian: Vedľajšie účinky z klinických štúdií:
English: The median PFS was 5.4 months.
Slovenian: Medián PFS bol 5,4 mesiaca.
English: Tolerance to TMZ is similar to adults.
Slovenian: Tolerancia na TMZ je podobná ako u dospelých.
English: TMZ can have genotoxic effects.
Slovenian: TMZ môže mať genotoxické účinky.
English: This is because you must not be treated with Temomedac during pregnancy unless clearly indicated by your doctor.
Slovenian: Je to kvôli tomu, že počas tehotenstva sa nesmiete liečiť Temomedac pokiaľ to jasne neurčí váš lekár.
English: These blood cells are important for fighting infection and for proper blood clotting.
Slovenian: Tieto krvinky sú dôležité na boj s infekciami a na správne zrážanie krvi.
English: - if you are older than 70 years of age, you might be more prone to infections, bruising or bleeding.
Slovenian: • ak ste starší ako 70 rokov, môžete byť náchylnejší na infekcie, modriny alebo krvácanie.
English: Dosage and duration of treatment
Slovenian: Dávkovanie a dĺžka trvania liečby
English: In this case, do not drive or use any tools or machines or cycle until you see how this medicine affects you (see section 4).
Slovenian: V takomto prípade neveďte vozidlo ani neobsluhujte žiadne nástroje alebo stroje alebo bicykel, pokiaľ nevidíte ako na vás tento liek vplýva (pozri časť 4).
English: OTHER SPECIAL WARNING(S), IF NECESSARY Cytotoxic.
Slovenian: INÉ ŠPECIÁLNE UPOZORNENIA, AK JE TO POTREBNÉ Cytotoxický.
English: † Including cases with fatal outcome * Frequencies estimated based on relevant clinical trials.
Slovenian: † Vrátane prípadov so smrteľným koncom * Frekvencie odhadnuté na základe príslušných klinických skúšaní.
English: Temomedac is used in these tumours if they return or get worse after standard treatment.
Slovenian: Temomedac sa používa pri týchto nádoroch, ak sa po štandardnej liečbe vrátia alebo sa zhoršia.
English: During treatment patients should be monitored and managed appropriately.
Slovenian: Počas liečby majú byť pacienti sledovaní a primerane liečení.
English: The reduction in blood cell counts is usually short-lived.
Slovenian: Zníženie počtu krviniek je zvyčajne krátkodobé.
English: Your doctor may decide to reduce the dose, interrupt, stop or change your treatment.
Slovenian: Váš lekár sa môže rozhodnúť znížiť dávku, prerušiť, ukončiť alebo zmeniť liečbu.
English: Your doctor will work out your exact dose.
Slovenian: Váš lekár stanoví vašu presnú dávku.
English: After Day 28, the next cycle will begin.
Slovenian: Po 28. dni sa začne ďalší cyklus.
English: Median overall survival was 14.6 months.
Slovenian: Medián celkového prežívania bol 14,6 mesiacov.
English: Do not give this medicine to children under the age of 3 years because it has not been studied.
Slovenian: Tento liek nedávajte deťom mladším ako 3 roky, pretože sa u nich neskúmal.
English: - if you have had an allergic reaction to dacarbazine (an anticancer medicine sometimes called DTIC).
Slovenian: • ak ste mali alergickú reakciu na dakarbazín (protirakovinový liek, niekedy nazývaný DTIC).
English: The half-life (t1/2) in plasma is approximately 1.8 hours.
Slovenian: Polčas (t1/2) v plazme je približne 1,8 hodín.
English: In some cases, it may be prolonged and may lead to a very severe form of anaemia (aplastic anaemia).
Slovenian: V niektorých prípadoch môže byť predĺžené a môže viesť k veľmi závažnej forme anémie (aplastická anémia).
English: At the time of granting the marketing authorisation, the submission of periodic safety update reports is not required for this medicinal product.
Slovenian: V čase vydania rozhodnutia o registrácii sa nevyžaduje pre tento liek predloženie periodicky aktualizovaných správ o bezpečnosti .
English: Hypersensitivity to dacarbazine (DTIC).
Slovenian: Precitlivenosť na dakarbazín (DTIC).
English: TMZ demonstrates low protein binding (10 % to 20 %), and thus it is not expected to interact with highly protein-bound substances.
Slovenian: TMZ vykazuje nízku väzbu na bielkoviny (10 % až 20 %), a preto sa neočakáva jeho interakcia s látkami, ktoré sa silne viažu na bielkoviny.
English: It may harm them,
Slovenian: A DOSAHU DETÍ
English: TMZ dose (mg/m²/day)
Slovenian: Dávka TMZ (mg/m²/deň)
English: You will take this dose every day for 42 days (up to 49 days) in combination with radiotherapy.
Slovenian: Túto dávku budete užívať každý deň počas 42 dní (až do 49 dní) v kombinácii s rádioterapiou.
English: Always take Temomedac exactly as your doctor has told you.
Slovenian: Vždy užívajte Temomedac presne tak, ako vám povedal váš lekár.
English: What Temomedac is and what it is used for
Slovenian: Čo je Temomedac a na čo sa používa
English: There may be up to 6 treatment periods (cycles).
Slovenian: Môžete dostať až 6 liečebných fáz (cyklov).
English: This daily dose depends on whether or not you have received chemotherapy before.
Slovenian: Táto denná dávka závisí od toho, či ste predtým dostávali chemoterapiu.
English: Other medicines and Temomedac
Slovenian: Iné lieky a Temomedac
English: If use during pregnancy must be considered, the patient should be apprised of the potential risk to the foetus.
Slovenian: Ak sa musí uvažovať o použití počas gravidity, pacientka musí byť oboznámená s možným rizikom pre plod.
English: Paediatric patients had a higher AUC than adult patients; however, the maximum tolerated dose (MTD) was 1,000 mg/m² per cycle both in children and in adults.
Slovenian: Pediatrickí pacienti mali vyššie AUC ako dospelí pacienti; avšak maximálna tolerovaná dávka (MTD) bola 1 000 mg/m²/cyklus u detí aj u dospelých.
English: ANNEX II
Slovenian: PRÍLOHA III
English: Take the missed dose as soon as possible during the same day.
Slovenian: Užite zabudnutú dávku čo najskôr počas toho istého dňa.
English: This latency period is very short even for an alkylating agent.
Slovenian: Táto doba latencie je veľmi krátka aj pre alkylačnú látku.
English: No studies have been conducted to determine the effect of TMZ on the metabolism or elimination of other medicinal products.
Slovenian: Nevykonali sa štúdie, ktoré by zisťovali účinok TMZ na metabolizmus alebo elimináciu iných liekov.
English: Weight decrease
Slovenian: pokles hmotnosti
English: If Temomedac comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Slovenian: Ak sa Temomedac dostane do kontaktu s kožou alebo sliznicou, okamžite a dôkladne sa musí postihnutá oblasť umyť mydlom a vodou.
English: Do not take a double dose to make up for a forgotten dose, unless your doctor tells you to do so.
Slovenian: Neužívajte dvojnásobnú dávku, aby ste nahradili vynechanú dávku, ak vám tak nepovedal váš lekár.
English: TMZ is more toxic to the rat and dog than to humans, and the clinical dose approximates the minimum lethal dose in rats and dogs.
Slovenian: TMZ je toxickejší pre potkany a psov ako pre ľudí a klinická dávka sa približuje minimálnej letálnej dávke u potkanov a u psov.
English: Interaction studies have only been performed in adults.
Slovenian: Pediatrická populácia Interakčné štúdie sa uskutočnili len u dospelých.
English: As it cannot be excluded that the change in Cmax is clinically significant, Temomedac should be administered without food.
Slovenian: Keďže nie je možné vylúčiť, že zmeny Cmax sú klinicky signifikantné, Temomedac sa nemá podávať s jedlom.
English: The objective response rate (ORR) based on MRI scans was 8 %.
Slovenian: Častosť objektívnej odpovede (Objective response rate - ORR), založená na MRI zobrazení, bola 8 %.
English: - as you may have a small risk of other changes in blood cells, including leukaemia.
Slovenian: • keďže môžete mať malé riziko iných zmien krviniek, vrátane leukémie.
English: During the monotherapy phase, the dose and way you take Temomedac will be different.
Slovenian: Počas fázy monoterapie bude dávka a spôsob akým budete užívať Temomedac odlišný.
English: In the event of an overdose, haematological evaluation is needed.
Slovenian: V prípade predávkovania je potrebné hematologické vyšetrenie.