FrancophonIA/ELRC3.0 huggingface dataset:
English: After surgery, once daily treatment may be continued for up to two further days.
Croatian: Nakon kirurškog zahvata liječenje jedanput na dan može se nastaviti još sljedeća dva dana.
English: Clinical field studies showed that robenacoxib was well-tolerated by most cats for up to 12 weeks.
Croatian: Klinička terenska ispitivanja pokazala su da je većina mačaka mlađa od 12 tjedana pokazala dobru toleranciju na robenakoksib.
English: Increases in liver enzyme activities associated with clinical signs of anorexia, apathy or vomiting were uncommon.
Croatian: Porasti u aktivnostima jetrenih enzima povezani s kliničkim znakovima anoreksije, apatije ili povraćanja bili su manje česti.
English: At the recommended dosage (2 mg/kg), analgesic, anti-inflammatory and anti-pyretic effects were demonstrated in an inflammation model, and in clinical trials, robenacoxib reduced pain and inflammation in cats undergoing orthopaedic or soft tissue surgery.
Croatian: Pri preporučenoj dozi (2 mg/kg) dokazani su analgetički, protuupalni i antipiretički učinci na model upale, a u kliničkim ispitivanjima robenakoksib je ublažio bol i upalu u mačaka koje su bile podvrgnute ortopedskim kirurškim zahvatima ili zahvatima na mekom tkivu.
English: Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID).
Croatian: Robenakoksib je nesteroidni protuupalni lijek (NSAID).
English: Do not use together with non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, medicines commonly used in the treatment of pain, inflammation and allergies.
Croatian: Ne primjenjivati s nesteroidnim protuupalnim lijekovima (NSAID) ili kortikosteroidima, lijekovima koji se obično primjenjuju za liječenje bola, upale i alergija.
English: Tablets:
Croatian: Tablete:
English: Pain at injection site was commonly reported.
Croatian: Bol na mjestu injekcije često je prijavljivan.
English: Acute musculo-skeletal disorders: treat for up to 6 days.
Croatian: Liječenje akutnih poremećaja mišićno-koštanog sustava: do 6 dana.
English: A reduction in body weight gain was observed in treated animals.
Croatian: U tretiranih životinja primijećeno je smanjeno dobivanje na težini.
English: STATEMENT OF ACTIVE SUBSTANCES 20 mg/ml Robenacoxib
Croatian: SASTAV DJELATNIH TVARI 20 mg/ml robenakoksib
English: Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class.
Croatian: Robenakoksib je nesteroidni protuupalni lijek (NSAID) iz klase koksiba.
English: At dosages ranging from 0.25 to 4 mg/kg, robenacoxib had analgesic, anti-inflammatory and anti-pyretic effects in an inflammation model with a rapid onset of action (1 h).
Croatian: Pri rasponu doziranja od 0,25 do 4 mg/kg robenakoksib je imao analgetičke, protuupalne i antipiretičke učinke na model upale s brzim početkom djelovanja (1 h).
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS NATURE/TYPE: Blister foil
Croatian: OSNOVNI PODACI KOJI SE MORAJU NALAZITI NA BLISTERIMA ILI TRAKAMA OSOBINE/TIP: Blister
English: 10 to < 20
Croatian: 10 do <20
English: INDICATION(S) Not applicable.
Croatian: INDIKACIJA(E) Nije primjenjivo.
English: In an inflammation model in cats, robenacoxib injection had analgesic, anti-inflammatory and anti-pyretic effects and a rapid onset of action (0.5 h).
Croatian: Kod modela upale u mačaka injekcije robenakoksiba imale su analgetičke, protuupalne i antipiretičke učinke i brz početak djelovanja (0,5 sata).
English: Concurrent use of other active substances that have a high degree of protein binding may compete with robenacoxib for binding and thus lead to toxic effects.
Croatian: Istodobna primjena drugih djelatnih tvari koje se izrazito vežu na proteine može izazvati naticanje tih tvari s robenakoksibom za vezanje na iste proteine te tako uzrokovati toksične učinke.
English: 5 mg tablets: Robenacoxib 5 mg 10 mg tablets: Robenacoxib 10 mg 20 mg tablets: Robenacoxib 20 mg 40 mg tablets: Robenacoxib 40 mg
Croatian: tablete od 5 mg: robenakoksib 5 mg tablete od 10 mg: robenakoksib 10 mg tablete od 20 mg: robenakoksib 20 mg tablete od 40 mg: robenakoksib 40 mg
English: Do not use concomitantly with corticosteroids or other non-steroidal anti-inflammatory drugs (NSAIDs).
Croatian: Ne primjenjivati istodobno s kortikosteroidima ili drugim nesteroidnim protuupalnim lijekovima (NSAID).
English: After intravenous administration robenacoxib was rapidly cleared from blood (CL of 0.44 L/kg/h in cats and 0.81 L/kg/h in dogs) with an elimination t1/2 of 1.1 h in cats and 0.8 h in dogs.
Croatian: Nakon intravenozne primjene robenakoksib se brzo eliminira iz krvi (CL od 0,44 l/kg/h u mačaka i 0,81 l/kg/h u pasa) s poluvremenom eliminacije od 1,1 h u mačaka i 0,8 h u pasa.
English: In case of accidental ingestion or self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
Croatian: U slučaju nehotičnog gutanja ili ubrizgavanja odmah potražite pomoć liječnika i pokažite mu uputu ili etiketu.
English: Robenacoxib is excreted predominantly via the biliary route in cats (∼70%) and dogs (∼65%) and the remainder via the kidneys.
Croatian: Robenakoksib se izlučuje uglavnom putem žuči u mačaka (∼70 %) i pasa (∼65 %), a ostatak putem bubrega.
English: Robenacoxib persists longer and in higher concentrations at sites of inflammation than in blood.
Croatian: Robenakoksib se zadržava dulje i u višim koncentracijama na mjestima upale nego u krvi.
English: Robenacoxib is excreted predominantly via the biliary route (∼70%) rather than via the kidneys (∼30%).
Croatian: Robenakoksib se izlučuje više putem žuči (∼70 %) nego putem bubrega (∼30 %).
English: Clear, colourless to slightly coloured (pink) liquid.
Croatian: Bistra bezbojna do blago obojena (ružičasta) tekućina.
English: Co-administration of robenacoxib non-flavoured tablets with food produced no delay in Tmax, but slightly lower values for Cmax (832 ng/ml) and AUC (782 ng·h/ml).
Croatian: Istodobna primjena tableta robenakoksiba bez umjetnog okusa s hranom nije uzrokovala odgodu u Tmax, ali su zabilježene lagano snižene vrijednosti za Cmax (832 ng/ml) i AUC (782 ng·h/ml).
English: Onsior tablets are flavoured and are taken voluntarily by most dogs.
Croatian: Tablete Onsior su aromatizirane te ih većina pasa uzima dobrovoljno.
English: Co-administration of robenacoxib tablets with one third of the daily food ration produced no change in Tmax (0.5 h), Cmax (1,201 ng/ml) or AUC (1383 ng·h/ml).
Croatian: Istodobna primjena tableta robenakoksiba s jednom trećinom dnevne porcije hrane nije uzrokovala promjenu u Tmax (0,5 h), Cmax (1,201 ng/ml) ili AUC (1383 ng·h/ml).
English: Robenacoxib is excreted predominantly via the biliary route (∼65%) and the remainder via the kidneys.
Croatian: Robenakoksib se izlučuje uglavnom putem žuči (∼65 %), a ostatak putem bubrega.
English: Pharmacotherapeutic group: Anti-inflammatory and antirheumatic products, non-steroids, coxibs.
Croatian: Farmakoterapijska grupa: protuupalni i antireumatski proizvodi, nesteroidi, koksibi.
English: 5 to < 10
Croatian: 5 do <10
English: Each tablet contains 6 mg robenacoxib.
Croatian: Jedna tableta sadržava 6 mg robenakoksiba.
English: Onsior tablets are easy to administer and well accepted by most cats.
Croatian: Tablete Onsior jednostavne su za primjenu i većina mačaka ih dobro prihvaća.
English: Robenacoxib had analgesic and anti-inflammatory actions in an inflammation model in dogs with single oral doses ranging from 0.5 to 8 mg/kg, with an ID50 of 0.8 mg/kg and a rapid onset of action (0.5 h).
Croatian: Robenakoksib je imao analgetičke i protuupalne učinke s modelom upale u pasa s pojedinim dozama davanim kroz usta u rasponu od 0,5 do 8 mg/kg s ID50 od 0,8 mg/kg i s brzim početkom djelovanja (0,5 sati).
English: INDICATION(S) Not applicable
Croatian: INDIKACIJA(E) Nije primjenjivo
English: In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Croatian: U slučaju nehotičnog gutanja odmah potražite pomoć liječnika i pokažite mu uputu ili etiketu.
English: NATURE/TYPE: Cardboard box
Croatian: OSOBINE/TIP: Staklena bočica
English: If use cannot be avoided, these dogs require careful monitoring.
Croatian: Ako se primjena proizvoda ne može izbjeći, takve pse potrebno je pomno nadzirati.
English: 2.5 to < 5
Croatian: 2,5 do <5
English: 2.5 to < 6
Croatian: 2,5 do <6
English: Repeated subcutaneous administration at dosages of 2-20 mg/kg produced no change in the blood profile, with neither bioaccumulation of robenacoxib nor enzyme induction.
Croatian: Opetovane subkutane primjene lijeka u dozama od 2 do 20 mg/kg nisu uzrokovale promjene u krvnoj slici niti su zabilježene bioakumulacija robenakoksiba ili indukcija enzima.
English: In clinical trials robenacoxib tablets reduced the lameness and inflammation of dogs with chronic osteoarthritis.
Croatian: U kliničkim ispitivanjima tablete robenakoksiba smanjile su šepanje i upalu u pasa s kroničnim osteoartritisom.
English: Robenacoxib is cleared rapidly from blood (CL 0.81 L/kg/h) with an elimination t1/2 of 0.7 h after intravenous administration.
Croatian: Robenakoksib se brzo eliminira iz krvi (CL 0,81 l/kg/h) s poluvremenom eliminacije t1/2 od 0,7 h nakon intravenozne primjene.
English: Vomiting was very commonly reported, and anorexia, diarrhoea, lethargy and inappropriate defecation were commonly reported in field studies with treatment up to 3 months in cats with chronic musculo-skeletal disorder, with similar frequencies in the Onsior and placebo treated cats.
Croatian: Povraćanje je prijavljivano vrlo često, a anoreksija, proljev, letargija i neodgovarajuća defekacija često su prijavljivani u terenskim ispitivanjima s terapijom od najviše 3 mjeseca u mačaka s kroničnim mišićno-koštanim poremećajem, sa sličnom učestalošću u mačaka koje su dobivale Onsior i mačaka koje su dobivale placebo.
English: This product reduced in clinical trials pain and inflammation in cats and dogs undergoing orthopaedic or soft tissue surgery.
Croatian: Proizvod je u kliničkim ispitivanjima ublažio bol i upalu u mačaka i pasa koji su bili podvrgnuti ortopedskim kirurškim zahvatima ili zahvatima na mekom tkivu.
English: The pharmacokinetics of robenacoxib injection do not differ between male and female cats and dogs, and are linear over the range of 0.25-4 mg/kg in dogs.
Croatian: Nema razlike između farmakokinetike robenakoksiba između ženki i mužjaka pasa i mačaka te su u obama slučajevima linearne u rasponu od 0,25 do 4 mg/kg u pasa.
English: In cats robenacoxib is extensively metabolised by the liver.
Croatian: U mačaka se robenakoksib u velikoj mjeri metabolizira u jetri.
English: It selectively inhibits the cyclooxygenase 2 enzyme (COX-2), which is responsible for pain, inflammation or fever.
Croatian: Selektivno inhibira enzim ciklooksigenazu 2 (COX-2) koji je odgovoran za bol, upalu ili groznicu.
English: Robenacoxib is extensively metabolised by the liver in cats and dogs.
Croatian: Robenakoksib se u velikoj mjeri metabolizira u jetri mačaka i pasa.
English: In healthy cats treated with or without the diuretic furosemide, concomitant administration of Onsior with the ACE inhibitor benazepril for 7 days was not associated with any negative effects on plasma aldosterone concentrations, plasma renin activity or glomerular filtration rate.
Croatian: U zdravih mačaka tretiranih diuretikom furosemidom ili mačaka koje nisu njime tretirane istodobna primjena Onsiora s ACE inhibitorom benazeprilom od 7 dana nije bila povezana ni s kakvim negativnim učincima na koncentracije aldosterona u plazmi, reninsku aktivnost plazme ni stopu glomerularne filtracije.
English: Multi-dose amber glass vial containing 20 ml solution for injection, closed with a rubber stopper and sealed with an aluminium cap. One vial packed in a cardboard box.
Croatian: Višedozna žuta staklena bočica koja sadržava 20 ml otopine za injekciju zatvorena gumenim čepom i aluminijskim poklopcem.
English: COX-1 is the constitutive form of the enzyme and has protective functions, e.g. in the gastrointestinal tract and kidneys.
Croatian: COX-1 sastavni je dio enzima i ima zaštitne funkcije, primjerice u probavnom sustavu i bubrezima.
English: Repeated oral administration of robenacoxib to dogs at dosages of 2-10 mg/kg for 6 months produced no change in the blood profile, with neither accumulation of robenacoxib nor enzyme induction.
Croatian: Ponovljena primjena robenakoksiba kroz usta u pasa u dozama od 2 do 10 mg/kg tijekom 6 mjeseci nije uzrokovala promjenu krvne slike niti je zabilježena akumulacija robenakoksiba ili indukcija enzima.
English: No safety data in the target population and no efficacy data in general exist for the combined treatment of robenacoxib and benazepril.
Croatian: Za kombiniranu terapiju robenakoksibom i benazeprilom ne postoje sigurni podaci u ciljnoj populaciji niti podaci o djelotvornosti općenito.
English: Slight pain at injection site was commonly reported.
Croatian: Blagi bol na mjestu injekcije često je prijavljivan.
English: In clinical trials in cats, robenacoxib tablets reduced pain and inflammation associated with acute musculo-skeletal disorders and reduced the need for rescue treatment when given as premedication in case of orthopaedic surgery, in combination with opioids.
Croatian: U kliničkim ispitivanjima na mačkama tablete robenakoksiba ublažile su bol i upalu povezane s akutnim mišićno koštanim poremećajima te su smanjile potrebu za terapijom spašavanja kad su se davale kao premedikacija u slučaju ortopedskih kirurških zahvata, u kombinaciji s opioidima.
English: In small children, accidental ingestion increases the risk for NSAID adverse effects.
Croatian: U male djece slučajno gutanje povećava rizik od nuspojava nesteroidnih protuupalnih lijekova.
English: After a dosage of 2 mg/kg a Tmax of 1 h (cats and dogs), a Cmax of 1,464 ng/ml (cats) and 615 ng/ml (dogs), and an AUC of 3,128 ng·h/ml (cats) and 2,180 ng·h/ml (dogs) is obtained.
Croatian: Nakon doziranja od 2 mg/kg postiže se Tmax od 1 h (mačke i psi), Cmax od 1464 ng/ml (mačke) i 615
English: In artificially induced inflammation in dogs, robenacoxib reduced pain and inflammation with single oral doses ranging from 0.5 to 8 mg/kg and a rapid onset of action (0.5 h).
Croatian: Kod umjetno izazvane upale u pasa robenakoksib je smanjio bol i upalu u pojedinim oralnim dozama u rasponu od 0,5 do 8 mg/kg i s brzim početkom djelovanja (0,5 h).
English: If use cannot be avoided, these animals require careful monitoring and fluid therapy.
Croatian: Ako se primjena ne može izbjeći, potrebno je pomno nadzirati te životinje te im davati tekućinu.
English: Robenacoxib is rapidly cleared from blood (CL 0.44 L/kg/h) with an elimination t1/2 of 1.1 h after intravenous administration.
Croatian: Robenakoksib se brzo eliminira iz krvi (CL 0,44 l/kg/h) s poluvremenom eliminacije od 1,1 sati nakon intravenozne primjene.
English: Robenacoxib has a relatively small volume of distribution (Vss of 190 ml/kg in cats and 240 ml/kg in dogs) and is highly bound to plasma proteins (>99%).
Croatian: Robenakoksib ima relativno mali volumen distribucije (Vss 190 ml/kg u mačaka i 240 ml/kg u pasa) te se izrazito veže za bjelančevine plazme (>99 %).
English: 5 mg tablet:
Croatian: tablete od 10 mg:
English: Pre-treatment with other anti-inflammatory medicines may result in additional or increased adverse effects and accordingly a treatment-free period with such substances should be observed for at least 24 hours before the commencement of treatment with Onsior.
Croatian: Prethodno liječenje drugim protuupalnim lijekovima može rezultirati dodatnim ili pojačanim neželjenim učincima, stoga prije početka liječenja proizvodom Onsior treba prekinuti liječenje takvim lijekovima na najmanje 24 sata.
English: The interchangeable use of Onsior tablets and Onsior solution for injection has been tested in a target animal safety study and was shown to be well tolerated by the cats.
Croatian: Naizmjenična uporaba tableta Onsior i otopine za injekcije Onsior ispitana je u ispitivanju sigurnosti ciljnih životinja te se pokazalo da je mačke dobro podnose.
English: Pre-treatment with other anti-inflammatory medicines may result in additional or increased adverse effects and, accordingly, a treatment-free period with such substances should be observed for at least 24 hours before the commencement of treatment with Onsior.
Croatian: Prethodno liječenje drugim protuupalnim lijekovima može rezultirati dodatnim ili pojačanim neželjenim učincima, stoga prije početka liječenja proizvodom Onsior prekinuti liječenje takvim lijekovima na najmanje 24 sata.
English: After oral administration of robenacoxib tablets at approximately 2 mg/kg without food, peak blood concentrations are attained rapidly with a Tmax of 0.5 h, a Cmax of 1,159 ng/ml and an AUC of 1,337 ng·h/ml.
Croatian: Nakon peroralne primjene tableta robenakoksiba u dozama od približno 2 mg/kg bez hrane vršne koncentracije u krvi postignute su brzo, s Tmax od 0,5 sati, Cmax od 1,159 ng/ml i AUC od 1,337
English: COX-2 activity and had no effect on COX-1 activity in dogs at oral doses ranging from 0.5 to 4 mg/kg.
Croatian: Robenakoksib je uzrokovao znatnu inhibiciju aktivnosti COX-2 i nije imao učinak na aktivnost COX-1 u pasa kod doza davanim kroz usta u rasponu od 0,5 do 4 mg/kg tjelesne težine.
English: In healthy young dogs aged 6 months, once daily subcutaneous administration of robenacoxib at doses of 2 (recommended therapeutic dose; RTD), 6 (3 times RTD), and 20 mg/kg (10 times RTD) for 9 administrations over a 5 week period (3 cycles of 3 consecutive once daily injections) did not produce any signs of toxicity, including gastrointestinal, kidney or liver toxicity and had no effect on bleeding time.
Croatian: U zdravih mladih pasa u dobi od 6 mjeseci subkutana primjena robenakoksiba jedanput na dan u dozama od 2 (preporučena terapijska doza; PTD), 6 (tri puta PTD) i 20 mg/kg (10 puta PTD) za 9 primjena tijekom pet tjedana (3 ciklusa od 3 uzastopne injekcije jedanput na dan) nije uzrokovala nikakve znakove toksičnosti, uključujući gastrointestinalnu toksičnost, toksičnost bubrega ili jetre, i nije utjecala na vrijeme krvarenja.
English: Cardboard box containing 6 x 1, 12 x 1, 30 x 1 or 60 x 1 tablets in Alu/Alu perforated unit dose blisters.
Croatian: Kartonska kutija koja sadržava 6 x 1, 12 x 1, 30 x 1 ili 60 x 1 tableta u Alu/Alu perforiranim blisterima s jediničnim dozama.
English: The recommended dose of robenacoxib is 1 mg/kg body weight with a range 1-2.4 mg/kg.
Croatian: Preporučena doza robenakoksiba je 1 mg/kg tjelesne težine s rasponom od 1 - 2,4 mg/kg.
English: For the reduction of moderate pain and inflammation associated with orthopaedic surgery in cats.
Croatian: Za ublažavanje umjerenog bola i upale povezanih s ortopedskim kirurškim zahvatima u mačaka.
English: The interchangeable use of Onsior tablets and Onsior solution for injection has been tested in a target animal safety study and was shown to be well tolerated by cats.
Croatian: Naizmjenična uporaba tableta Onsior i otopine za injekcije Onsior ispitana je u ispitivanju sigurnosti ciljnih životinja se pokazalo da mačke dobro podnose.
English: For cats, Onsior solution for injection or tablets may be used interchangeably in accordance with the indications and directions of use approved for each pharmaceutical form.
Croatian: U mačaka se Onsior otopina za injekcije ili tablete mogu naizmjenično upotrebljavati u skladu s indikacijama i uputama za uporabu odobrenim za svaki farmaceutski oblik.
English: No changes in the QT interval were observed after a single intravenous administration of 2 or 4 mg/kg robenacoxib to anaesthetised healthy cats.
Croatian: Nisu uočene promjene QT intervala nakon jedne intravenozne primjene 2 ili 4 mg/kg robenakoksiba na anesteziranim zdravim mačkama.
English: Gastrointestinal adverse events were reported very commonly, but most cases were mild and recovered without treatment.
Croatian: Gastrointestinalne nuspojave prijavljivane su vrlo često, ali većina slučajeva bila je blaga i povukla se bez liječenja.
English: Gastrointestinal adverse events (vomiting, soft faeces or diarrhoea) were commonly reported, but most cases were mild and recovered without treatment.
Croatian: Gastrointestinalne nuspojave (povraćanje, mekana stolica ili proljev) zabilježene su često, ali većina slučajeva bila je blaga i prošla je bez liječenja.
English: COX-2 is the inducible form of the enzyme which is responsible for the production of mediators including PGE2 which induce pain, inflammation or fever.
Croatian: COX-2 je inducibilni oblik enzima odgovoran za generiranje medijatora, uključujući PGE2 koji inducira bol, upalu ili groznicu.
English: Yeast powder Cellulose, microcrystalline Flavour, artificial beef Cellulose, powdered Povidone (K-30) Crospovidone Silica, colloidal anhydrous Magnesium stearate
Croatian: Umjetni okus govedine Celuloza u prahu Povidon (K-30) Krospovidon
English: Robenacoxib has a relatively small volume of distribution (Vss 190 ml/kg) and is highly bound to plasma proteins (>99%).
Croatian: Robenakoksib ima relativno mali volumen distribucije (Vss 190 ml/kg) te se izrazito veže za bjelančevine plazme (>99 %).
English: A dose-dependent increase in the QT interval, a decreased heart rate and corresponding increased respiratory rate were observed in laboratory studies.
Croatian: U laboratorijskim ispitivanjima zabilježeni su povećanje QT intervala povezano s doziranjem, smanjen broj otkucaja srca i odgovarajuće povećanje brzine disanja.
English: Robenacoxib has a relatively small volume of distribution (Vss 240 ml/kg) and is highly bound to plasma proteins (>99%).
Croatian: Robenakoksib ima relativno mali volumen distribucije (Vss 240 ml/kg) te se izrazito veže za bjelančevine plazme (>99 %).
English: Onsior 5 mg tablets for dogs Onsior 10 mg tablets for dogs Onsior 20 mg tablets for dogs Onsior 40 mg tablets for dogs
Croatian: Onsior 5 mg tablete za pse Onsior 10 mg tablete za pse Onsior 20 mg tablete za pse Onsior 40 mg tablete za pse
English: For the treatment of pain and inflammation associated with chronic osteoarthritis in dogs.
Croatian: Za liječenje bola i upale povezanih s kroničnim osteoartritisom u pasa.
English: Cardboard box containing 7, 14, 28 or 70 tablets in Alu/Alu blisters, 30 x 1 tablets in Alu/Alu perforated unit dose blisters or 60 x 1 tablets in Alu/Alu perforated unit dose blisters.
Croatian: Kartonska kutija koja sadržava 7, 14, 28 ili 70 tableta u Alu / Alu blisteru, 30 x 1 tableta u Alu / Alu perforiranim blisterima s jediničnim dozama ili 60 x 1 tableta u Alu / Alu perforiranim blisterima s jediničnim dozama.
English: As with any NSAID, overdose may cause gastrointestinal, kidney, or liver toxicity in sensitive or compromised animals.
Croatian: Kao i s bilo kojim nesteroidnim protuupalnim lijekom, predoziranje može uzrokovati gastrointestinalnu, bubrežnu ili jetrenu toksičnost u osjetljivih životinja ili životinja oslabljenog imuniteta.
English: Do not use in dogs suffering from stomach ulcer or with liver disease.
Croatian: Ne primjenjivati u pasa koji pate od ulceracija u probavnom sustavu ili od bolesti jetre.
English: PACKAGE LEAFLET: Onsior 20 mg/ml solution for injection for cats and dogs
Croatian: Onsior 20 mg/ml otopina za injekcije za mačke i pse
English: After oral administration of robenacoxib flavoured tablets at 1 mg/kg without food, peak blood concentrations are attained rapidly with a Tmax of 0.5 h, a Cmax of 1,124 ng/ml and an AUC of 1,249 ng·h/ml.
Croatian: Nakon primjene tableta robenakoksiba s umjetnim okusom u dozama od 1 mg/kg kroz usta bez hrane, vršne koncentracije u krvi postignute su brzo, s Tmax od 0,5 sati, Cmax od 1124 ng/ml i AUC od 1249 ng·h/ml.
English: The recommended dose of robenacoxib is 1 mg/kg body weight with a range 1-2 mg/kg.
Croatian: Preporučena doza robenakoksiba je 1 mg/kg tjelesne težine u rasponu od 1 do 2 mg/kg.
English: If use cannot be avoided, these cats require careful monitoring.
Croatian: Ako se primjena proizvoda ne može izbjeći, potrebno je pomno nadzirati takve mačke.
English: The pharmacokinetics of robenacoxib do not differ between male and female dogs, and are linear over the range 0.5-8 mg/kg.
Croatian: Nema razlike između farmakokinetike robenakoksiba između ženki i mužjaka pasa te su u oba slučaja linearne u rasponu od 0,5 do 8 mg/kg.