FrancophonIA/ELRC3.0 huggingface dataset:
English: The aprepitant regimen in combination with an ondansetron/dexamethasone regimen (see section 4.2) was compared with standard therapy (placebo in combination with ondansetron 8 mg orally (twice on Day 1, and every 12 hours on Days 2 and 3) plus dexamethasone 20 mg orally on Day 1).
Danish: 4.2) blev sammenlignet med standardbehandlingen (placebo i kombination med ondansetron 8 mg oralt (to gange på dag 1 og hver 12. time på dag 2 og 3) plus dexamethason 20 mg oralt på dag 1).
English: When a single 125 mg dose of EMEND was administered on Day 1 and 80 mg/day on Days 2 and 3 to healthy subjects who were stabilised on chronic warfarin therapy, there was no effect of EMEND on the plasma AUC of R(+) or S(-) warfarin determined on Day 3; however, there was a 34 % decrease in S(-) warfarin (a CYP2C9 substrate) trough concentration accompanied by a 14 % decrease in INR 5 days after completion of EMEND.
Danish: Når en enkelt 125 mg dosis EMEND blev administreret på dag 1 og 80 mg/dag på dag 2 og 3 til raske forsøgspersoner, som var stabile på kronisk warfarinbehandling, var der ingen virkning af EMEND på AUC af R(+) eller S(-) warfarin i plasma på dag 3; der var dog et fald på 34% i dalkoncentrationen af S(-) warfarin (et CYP2C9substrat) ledsaget af et fald på 14% i INR 5 dage efter afslutning af EMEND.
English: Hepatic impairment
Danish: Ructus, kvalme
English: Each hard capsule contains 80 mg of aprepitant.
Danish: Hver hård kapsel indeholder 80 mg aprepitant.
English: - If you have any further questions, ask the doctor, pharmacist, or nurse.
Danish: Er du i tvivl, så spørg lægen, apotekspersonalet eller sundhedspersonalet.
English: Nervous system disorders dysarthria, hypoaesthesia, sensory disturbance uncommon
Danish: Dysartri, hypæstesi, føleforstyrrelser
English: The total exposure of orally administered CYP3A4 substrates may increase up to approximately 3-fold during the 3-day treatment with EMEND; the effect of aprepitant on the plasma concentrations of intravenously administered CYP3A4 substrates is expected to be smaller.
Danish: Den totale eksponering for oralt administrerede CYP3A4-substrater kan øges op til ca. 3 gange under 3-dages behandlingen med EMEND.
English: Each hard capsule contains 125 mg of aprepitant.
Danish: Hver hård kapsel indeholder 125 mg aprepitant.
English: EMEND 165 mg hard capsules Aprepitant
Danish: EMEND 165 mg hårde kapsler aprepitant
English: See the Summary of Product Characteristics (SmPC) for the selected 5-HT3 antagonist for appropriate dosing information.
Danish: Se produktresuméet (SmPC) for den valgte 5HT3-antagonist for information om hensigtsmæssig dosering.
English: The 80 mg capsules are opaque with a white body and cap with “461” and “80 mg” printed radially in black ink on the body.
Danish: 80 mg kapslen er ugennemsigtig med hvid kerne og kappe med ”461” og ”80 mg” præget med sort blæk på kapslen.
English: Fertility studies did not indicate direct or indirect harmful effects with respect to mating performance, fertility, embryonic/foetal development, or sperm count and motility (see section 5.3).
Danish: Fertilitetsstudier viste ingen direkte eller indirekte skadelige virkninger med hensyn til parringsaktivitet, fertilitet, embryonal/føtal udvikling eller sædkvalitet og motilitet (se pkt.
English: EU/1/03/262/009 1 hard capsule EU/1/03/262/010 6 x 1 hard capsule
Danish: EU/1/03/262/009 1 hård kapsel EU/1/03/262/010 6 x 1 hård kapsel
English: Tell the doctor, pharmacist or nurse if the child is using, has recently used or might use any other medicines.
Danish: Fortæl det altid til lægen, apotekspersonalet eller sundhedspersonalet, hvis barnet tager anden medicin eller har gjort det for nylig.
English: In 2 randomised, double-blind studies encompassing a total of 1,094 adult patients receiving chemotherapy that included cisplatin  70 mg/m2, aprepitant in combination with an ondansetron/dexamethasone regimen (see section 4.2) was compared with a standard regimen (placebo plus ondansetron 32 mg intravenously administered on Day 1 plus dexamethasone 20 mg orally on Day 1 and 8 mg orally twice daily on Days 2 to 4).
Danish: I 2 randomiserede, dobbeltblindede studier omfattende totalt 1.094 voksne patienter, der fik kemoterapi, inkluderende cisplatin  70 mg/m2, blev aprepitant i kombination med et ondansetron/dexamethason behandlingsregime (se pkt.
English: Titanium dioxide (E 171) Yellow iron oxide (E 172)
Danish: Titandioxid (E171) Gul jernoxid (E172)
English: What EMEND looks like and contents of the pack The 165 mg hard capsule is opaque with a light blue cap and a white body with “466” and “165 mg” printed radially in black ink on one side of the body and the Merck logo on the other side.
Danish: 165 mg kapslen er ugennemsigtig med en lyseblå kappe og hvid kerne med "466" og "165 mg" præget med sort blæk på den ene side af kapslen og Merck-logoet på den anden side.
English: EU/1/03/262/001 1 hard capsule EU/1/03/262/002 2 x 1 hard capsule EU/1/03/262/003 5 x 1 hard capsule
Danish: EU/1/03/262/001 1 hård kapsel EU/1/03/262/002 2 x 1 hård kapsel EU/1/03/262/003 5 x 1 hård kapsel
English: These fertility studies did not indicate direct or indirect harmful effects with respect to mating performance, fertility, embryonic/foetal development, or sperm count and motility (see section 5.3).
Danish: I disse fertilitetsstudier var der ingen indikation af direkte eller indirekte skadelige virkninger med hensyn til parringsaktivitet, fertilitet, embryonal/føtal udvikling eller spermtal og motilitet (se pkt.
English: EMEND 125 mg powder for oral suspension
Danish: EMEND 125 mg pulver til oral suspension
English: In patients on chronic warfarin therapy, the International Normalised Ratio (INR) should be monitored closely during treatment with EMEND and for 14 days following the use of EMEND (see section 4.5).
Danish: Samtidig administration af warfarin (CYP2C9-substrat) Hos patienter i kronisk warfarinbehandling bør International Normaliseret Ratio (INR) overvåges nøje under behandling med EMEND og i 14 dage efter anvendelse af EMEND (se pkt.
English: If the child gets any side effects, talk to the doctor, pharmacist, or nurse.
Danish: Hvis barnet oplever bivirkninger, bør du tale med din læge, sygeplejerske eller apoteket.
English: Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Danish: Fortæl det altid lægen eller apotekspersonalet, hvis du tager anden medicin eller har gjort det for nylig.
English: Skin and subcutaneous tissue rash, acne uncommon
Danish: Hud og subkutane væv Udslæt, akne
English: - If the child will have chemotherapy - give this medicine one hour before the start of the chemotherapy session.
Danish: - Giv lægemidlet en time før kemoterapibehandlingen starter, hvis barnet skal have kemoterapi.
English: The most common adverse reaction reported at a greater incidence in patients treated with the 3-day oral aprepitant regimen than with standard therapy in patients receiving Moderately Emetogenic Chemotherapy (MEC) was fatigue (1.4 % versus 0.9 %).
Danish: Moderat emetogen kemoterapibehandling (MEC): Den almindeligste bivirkning, som blev rapporteret med højere incidens hos de patienter, der blev behandlet med 3-dages regimet med oral aprepitant, end hos de patienter, der fik standardbehandling, var træthed (1,4% mod 0,9%).
English: - If chemotherapy is given, take EMEND 1 hour before you start your chemotherapy session.
Danish: - Tag EMEND 1 time før kemoterapibehandlingen starter, hvis du skal have kemoterapi.
English: The oral suspension can be kept at room temperature (not above 30 oC) for up to 3 hours, prior to administration.
Danish: Den orale suspension kan opbevares ved almindelig temperatur (højst 30 °C) i op til 3 timer, før den gives.
English: 5 Aluminium blisters each containing one 125 mg capsule.
Danish: 5 stk. aluminiumblistre med 1 stk. 125 mg kapsel i hver.
English: See the product information for the selected 5-HT3 antagonist for the appropriate dosing information
Danish: Se produktinformationen for den valgte 5-HT3antagonist for information om hensigtsmæssig dosering
English: Uncommon: may affect up to 1 in 100 people - feeling dizzy or sleepy - acne, rash - feeling anxious - burping, nausea, vomiting, heartburn, stomach pain, dry mouth, passing wind - pain or burning when urinating - feeling weak, generally feeling unwell - hot flushes/reddening of the face or skin - fast or irregular heart beat - fever with increased risk of infection, low number of red blood cells (shown in tests).
Danish: Ikke almindelig: kan forekomme hos op til 1 ud af 100 personer - Svimmelhed eller søvnighed - Akne, udslæt - Angst - Opstød, kvalme, opkastning, halsbrand, mavesmerter, mundtørhed, luftafgang fra tarmen - Smertefuld og sviende fornemmelse ved vandladning - Svaghed, generel utilpashed - Hedeture/rødme i ansigtet eller huden - Hurtig eller uregelmæssig hjerterytme (puls) - Feber med øget risiko for infektion, lavt antal røde blodlegemer (fremgår af blodprøver).
English: calculated using stratified Miettinen-Nurminen method using CochranMantel-Haenszel weights
Danish: Forskel (%) og 95 % CI (konfidensinterval) beregnet ved hælp af stratificeret Miettinen-Nurminen metode med anvendelse af Cochran-Mantel-Haenszel vægte.
English: EMEND 40 mg hard capsules
Danish: EMEND 40 mg hårde kapsler.
English: Stevens-Johnson syndrome/toxic epidermal necrolysis (rare severe skin reaction), - euphoria (feeling of extreme happiness), disorientation, - bacterial infection, fungal infection, - severe constipation, stomach ulcer, inflammation of the small intestine and colon, sores in mouth, bloating, - frequent urination, passing more urine than normal, presence of sugar or blood in urine, - chest discomfort, swelling, change in the manner of walking, - cough, mucus in back of throat, throat irritation, sneezing, sore throat, - eye discharge and itching, - ringing in the ear, - muscle spasms, muscle weakness, - excessive thirst, - slow heartbeat, heart and blood vessel disease, - lowering of white blood cells, low sodium levels in the blood, weight loss.
Danish: Sjældne bivirkninger (kan berøre op til 1 ud af 1.000 personer): - Koncentrationsbesvær, manglende energi, smagsforstyrrelser - Øget hudfølsomhed over for solen, kraftigt øget svedtendens, fedtet hud, sår på huden, kløende udslæt, Stevens-Johnsons syndrom/toksisk epidermal nekrolyse (sjælden alvorlig hudreaktion) - Eufori (ekstrem lykkefølelse), desorientering - Bakterieinfektion, svampeinfektion - Svær forstoppelse, mavesår, betændelse i tyndtarmen og tyktarmen, sår i munden, oppustethed - Hyppig vandladning, større urinmængde end normalt, sukker eller blod i urinen - Ubehag i brystet, hævelser, ændringer i måden at gå på - Hoste, slim bagest i svælget, irritation i svælget, nysen, ondt i halsen - Tåreflåd og øjenkløe - Ringen for ørerne - Muskelspasmer, muskelsvækkelse - Udtalt tørst - Langsom hjerterytme (puls), sygdom i hjerte- eller blodkar - Fald i antal hvide blodlegemer, lavt indhold af natrium i blodet, vægttab.
English: Aluminium blister containing one 80 mg capsule.
Danish: Aluminiumblister med 1 stk. 80 mg kapsel.
English: - The other ingredients are: sucrose, microcrystalline cellulose (E 460), hydroxypropylcellulose (E 463), sodium laurilsulfate, gelatin, titanium dioxide (E 171), shellac, potassium hydroxide, and black iron oxide (E 172); the 125 mg hard capsule also contains red iron oxide (E 172) and yellow iron oxide (E 172).
Danish: - Øvrige indholdsstoffer: Saccharose, mikrokrystallinsk cellulose (E460), hydroxypropylcellulose (E463), natriumlaurilsulfat, gelatine, titandioxid (E171), shellak, kaliumhydroxid og sort jernoxid (E172).
English: A summary of the key study results is shown in Table 3.
Danish: En opsummering af nøgleresultaterne fra undersøgelserne fremgår af tabel 3.
English: Do not give this medicine if any of the above applies to the child and tell the child's doctor if they are using any of the medicines above.
Danish: Fortæl barnets læge, hvis barnet anvender et eller flere af ovenstående lægemidler.
English: If you have any further questions on the use of this medicine, ask the doctor or pharmacist.
Danish: Er du i tvivl, så spørg lægen eller apotekspersonalet.
English: Your child may need blood tests during treatment with EMEND - antibiotics to treat infections - such as rifampicin, clarithromycin, telithromycin - phenytoin - for fits (seizures) - carbamazepine - for depression and epilepsy - midazolam, triazolam, phenobarbital - to produce calmness or help you sleep - St. John's Wort - a herbal medicine for depression - protease inhibitors - for HIV infections - ketoconazole except shampoo (used to treat Cushing's syndrome - when the body produces an excess of cortisol) - antifungal medicines such as itraconazole, voriconazole, posaconazole - nefazodone - for depression - corticosteroids - such as dexamethasone and methylprednisolone - medicines for anxiety such as alprazolam - tolbutamide - for diabetes - contraceptive medicines including pills, patches, implants, and some Intrauterine devices
Danish: Dit barn skal eventuelt have taget blodprøver i løbet af behandlingen med EMEND - rifampicin, clarithromycin, telithromycin (antibiotika til behandling af infektioner) - phenytoin (til behandling af krampeanfald) - carbamazepin (til behandling af depression og epilepsi) - midazolam, triazolam, phenobarbital (beroligende midler eller sovemidler) - perikon (et naturlægemiddel til behandling af depression) - proteasehæmmere (til behandling af hiv-infektioner) - ketoconazol undtagen shampoo (til behandling af Cushings syndrom - når kroppen producerer for meget kortisol) - itraconazol, voriconazol, posaconazol (til behandling af svampeinfektioner) - nefazodon (til behandling af depression) - kortikosteroider (såsom dexamethason og methylprednisolon) - angstdæmpende medicin såsom alprazolam - tolbutamid (medicin til behandling af sukkersyge diabetes) - præventionsmidler, herunder p-piller, plastre, implantater og visse former for hormonspiral.
English: Capsules are opaque with a white body and mustard yellow cap with “464” and “40 mg” printed radially in black ink on the body.
Danish: Kapslerne er ugennemsigtige med hvid kerne og sennepsgul kappe med "464" og "40 mg" præget med sort blæk på den ene halvdel af kapslen.
English: When you have finished do not throw away any medicines via wastewater or household waste.
Danish: Af hensyn til miljøet må du ikke smide medicinrester i afløbet, toilettet eller skraldespanden.
English: If the dose is not administered immediately after measuring, store filled oral dispenser(s) in the refrigerator between 2°C-8°C for up to 72 hours prior to use.
Danish: fyldte dispenseringssprøjte(r) til oral anvendelse opbevares i køleskab (mellem 2 °C og 8 °C) i op til 72 timer før anvendelse.
English: No dose adjustment for EMEND is necessary for patients with renal impairment or for patients with ESRD undergoing haemodialysis.
Danish: Dosisjustering af EMEND er ikke nødvendig til patienter med nedsat nyrefunktion eller for hæmodialysepatienter i det sene stadie (end stage) af nyresygdom.
English: It is important that you tell your doctor if you are breast-feeding or are planning to breast-feed before taking this medicine.
Danish: Før du tager dette lægemiddel, er det vigtigt, at du fortæller lægen, om du ammer eller planlægger at amme.
English: Each sachet contains 125 mg of aprepitant.
Danish: Hver foliepose indeholder 125 mg aprepitant.
English: EU/1/03/262/004 1 hard capsule EU/1/03/262/005 5 x 1 hard capsule
Danish: EU/1/03/262/004 1 hård kapsel EU/1/03/262/005 5 x 1 hård kapsel
English: Uncommon side effects (may affect up to 1 in 100 people) are: - dizziness, sleepiness, - acne, rash, - anxiousness, - burping, nausea, vomiting, heartburn, stomach pain, dry mouth, passing wind, - increased painful or burning urination, - weakness, generally feeling unwell, - hot flush, - fast or irregular heartbeats, - fever with increased risk of infection, lowering of red blood cells.
Danish: Ikke almindelige bivirkninger (kan berøre op til 1 ud af 100 personer): - Svimmelhed, søvnighed - Akne, udslæt - Angst - Opstød, kvalme, opkastning, halsbrand, mavesmerter, mundtørhed, luftafgang fra tarmen - Øget smertefuld og sviende fornemmelse ved vandladning - Svaghed, generel utilpashed - Hedeture - Hurtig eller uregelmæssig hjerterytme (puls) - Feber med øget risiko for infektion, fald i antal røde blodlegemer.
English: Sachet for EMEND 125 mg powder for oral suspension
Danish: Foliepose til EMEND 125 mg pulver til oral suspension
English: It is important to tell the doctor if you or the child are breast-feeding or are planning to breast-feed before taking this medicine.
Danish: Før du eller barnet tager dette lægemiddel, er det vigtigt at fortælle lægen, om du eller barnet ammer eller planlægger at amme.
English: cyclosporine, tacrolimus, sirolimus, everolimus (immunosuppressants), - alfentanil, fentanyl (used to treat pain), - quinidine (used to treat an irregular heart beat), - irinotecan, etoposide, vinorelbine, ifosfamide (medicines used to treat cancer), - medicines containing ergot alkaloid derivatives such as ergotamine and diergotamine (used for treating migraines), - warfarin, acenocoumarol (blood thinners; blood tests may be required), - rifampicin, clarithromycin, telithromycin (antibiotics used to treat infections), - phenytoin (a medicine used to treat seizures), - carbamazepine (used to treat depression and epilepsy), - midazolam, triazolam, phenobarbital (medicines used to produce calmness or help you sleep), - St. John's Wort (an herbal preparation used to treat depression), - protease inhibitors (used to treat HIV infections) - ketoconazole except shampoo (used to treat Cushing's syndrome - when the body produces an excess of cortisol), - itraconazole, voriconazole, posaconazole (antifungals), - nefazodone (used to treat depression), - corticosteroids (such as dexamethasone and methylprednisolone), - anti-anxiety medicines (such as alprazolam), - tolbutamide (a medicine used to treat diabetes)
Danish: - Ciclosporin, tacrolimus, sirolimus, everolimus (medicin der hæmmer dannelsen af antistoffer) - Alfentanil, fentanyl (til behandling af smerter) - Quinidin (til behandling af uregelmæssig hjerterytme) - Irinotecan, etoposid, vinorelbin, ifosfamid (medicin til behandling af cancer) - Lægemidler der indeholder sekalealkaloider, såsom ergotamin og diergotamin (til behandling af migræne) - Warfarin, acenocoumarol (midler til blodfortynding; det kan måske være nødvendigt at tage blodprøver) - Rifampicin, clarithromycin, telithromycin (antibiotika til behandling af infektioner) - Phenytoin (til behandling af krampeanfald) - Carbamazepin (til behandling af depression og epilepsi) - Midazolam, triazolam, phenobarbital (beroligende midler eller sovemidler) - Perikon (et naturlægemiddel til behandling af depression) - Proteasehæmmere (til behandling af hiv-infektioner) - Ketoconazol undtagen shampoo (til behandling af Cushings syndrom - når kroppen producerer for meget kortisol) - Itraconazol, voriconazol, posaconazol (til behandling af svampeinfektioner) - Nefazodon (til behandling af depression) - Kortikosteroider (såsom dexamethason og methylprednisolon) - Angstdæmpende medicin (såsom alprazolam) - Tolbutamid (medicin til behandling af diabetes).
English: Ondansetron 4 mg intravenously (N=526)
Danish: Ondansetron 4 mg i.v.
English: Gastrointestinal disorders constipation, dyspepsia common eructation, nausea*, vomiting*, gastroesophageal reflux disease, abdominal pain, dry mouth, flatulence uncommon duodenal ulcer perforation, stomatitis, abdominal distension, faeces hard, neutropenic colitis rare
Danish: Opstød, kvalme*, opkastning*, gastroøsofageal reflukslidelse, mavesmerter, mundtørhed, flatulens
English: black iron oxide (E 172), and yellow iron oxide (E 172).
Danish: 125 mg kapslen indeholder også rød jernoxid (E172) og gul jernoxid (E172).
English: EU/1/03/262/007 1 hard capsule EU/1/03/262/008 5 x 1 hard capsule
Danish: EU/1/03/262/007 1 hård kapsel EU/1/03/262/008 5 x 1 hård kapsel
English: everolimus - alfentanil, fentanyl - for pain - quinidine - for irregular heart beat - medicines for cancer - such as irinotecan, etoposide, vinorelbine, ifosfamide - medicines containing ‘ergot alkaloid derivatives' - such as ergotamine and diergotamine - for migraines - medicines that thin the blood - such as warfarin, acenocoumarol.
Danish: Tal med lægen, apotekspersonalet eller sundhedspersonalet, hvis barnet tager et eller flere af følgende lægemidler: - lægemidler, der påvirker immunsystemet - såsom ciclosporin, tacrolimus, sirolimus, everolimus - alfentanil, fentanyl (til behandling af smerter) - quinidin (til behandling af uregelmæssig hjerterytme) - irinotecan, etoposid, vinorelbin, ifosfamid (medicin til behandling af kræft) - lægemidler, der indeholder ”sekalealkaloider” - såsom ergotamin og diergotamin (til behandling af migræne) - warfarin, acenocoumarol (blodfortyndende medicin).
English: The medicine can be kept at room temperature (not above 30
Danish: Den orale suspension kan opbevares ved almindelig temperatur (højst 30
English: Uncommon side effects (may affect up to 1 in 100 people) are: - dizziness, sleepiness, - acne, rash, - anxiousness, - burping, nausea, vomiting, heartburn, stomach pain, dry mouth, passing wind, - increased painful or burning urination, - weakness, generally feeling unwell, - hot flush/reddening of the face or skin, - fast or irregular heartbeats, - fever with increased risk of infection, lowering of red blood cells.
Danish: Ikke almindelige bivirkninger (kan berøre op til 1 ud af 100 personer): - Svimmelhed, søvnighed - Akne, udslæt - Angst - Opstød, kvalme, opkastning, halsbrand, mavesmerter, mundtørhed, luftafgang fra tarmen - Øget smertefuld og sviende fornemmelse ved vandladning - Svaghed, generel utilpashed - Hedeture/rødme i ansigtet eller huden - Hurtig eller uregelmæssig hjerterytme (puls) - Feber med øget risiko for infektion, fald i antal røde blodlegemer.
English: A summary of the key study results is shown in Table 2.
Danish: En opsummering af nøgleresultaterne ses i tabel 2.
English: Caution is advised during concomitant administration of EMEND and orally administered active substances that are metabolised primarily through CYP3A4 and with a narrow therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine, ergotamine, fentanyl, and quinidine (see section 4.4).
Danish: Det tilrådes at udvise forsigtighed ved samtidig administration af EMEND og orale aktive substanser, der primært metaboliseres gennem CYP3A4, og som har et smalt terapeutisk virkningsområde såsom ciclosporin, tacrolimus, sirolimus, everolimus, alfentanil, diergotamin, ergotamin, fentanyl og quinidin (se pkt.
English: Caution is advised during concomitant administration of EMEND and active substances that are metabolised primarily through CYP3A4 and with a narrow therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine, ergotamine, fentanyl, and quinidine (see section 4.4).
Danish: Det tilrådes at udvise forsigtighed ved samtidig administration af EMEND og aktive substanser, der primært metaboliseres gennem CYP3A4, og som har et smalt terapeutisk virkningsområde såsom ciclosporin, tacrolimus, sirolimus, everolimus, alfentanil, diergotamin, ergotamin, fentanyl og quinidin (se pkt.
English: If a doctor has told you that the child has an intolerance to some sugars, contact the doctor before giving this medicine to the child.
Danish: Kontakt lægen, før du giver denne medicin til barnet, hvis lægen har fortalt dig, at barnet ikke kan tåle visse sukkerarter.
English: EMEND should be used with caution in patients receiving concomitant active substances that are metabolised primarily through CYP3A4 and with a narrow therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, ergot alkaloid derivatives, fentanyl, and quinidine (see section 4.5).
Danish: EMEND bør anvendes med forsigtighed hos patienter, der samtidigt får aktive substanser, som primært metaboliseres gennem CYP3A4, og som har et smalt terapeutisk virkningsområde, såsom ciclosporin, tacrolimus, sirolimus, everolimus, alfentanil, sekalealkaloidderivater, fentanyl og quinidin (se pkt.