FrancophonIA/ELRC3.0 huggingface dataset:
English: This activation of potassium channels induces vascular cell membrane hyperpolarisation with an arterial muscle relaxant effect, thereby leading to arterial dilatation and afterload reduction.
Croatian: Ta aktivacija kalijskih kanala uzrokuje hiperpolarizaciju staničnih membrana u krvnoj žili s opuštajućim djelovanjem na mišićni sloj u arterijama te stoga dovodi do dilatacije arterija i smanjenja tlačnog opterećenja.
English: This can develop problems such as bleeding (blood in your stools or vomit), fistula (abnormal tube-like passage from one body cavity to another or to the skin), wholes, abscess, weight loss.
Croatian: Iz toga se mogu razviti problemi kao što su krvarenje (krv u stolici ili povraćenom sadržaju), fistula (abnormalan cjevoliki spoj između dvije tjelesne šupljine ili između tjelesne šupljine i kože), otvori (puknuća), apsces, gubitak težine.
English: Nicorandil, a nicotinamide ester, is a vasodilator agent with a dual mechanism of action, which leads to relaxation of smooth tonic vascular muscles in both venous and arterial part of vessels.
Croatian: Nikorandil, ester nikotinamida, vazodilatatorni je lijek s dvostrukim mehanizmom djelovanja koji dovodi do opuštanja glatkih mišića krvnih žila i u venama i u arterijama.
English: This effect can be increased in conjunction with alcohol or other medicinal products with blood pressure lowering effect (e.g. vasodilators, tricyclic antidepressants) (see section 4.5).
Croatian: Učinak može biti pojačan u kombinaciji s alkoholom ili drugim lijekovima s učinkom snižavanja krvnog tlaka (npr. vazodilatatorima, tricikličkim antidepresivima) (vidjeti dio 4.5).
English: This can develop problems such as bleeding, fistula, wholes, abscess, especially if you have diverticular disease
Croatian: Zbog toga se mogu razviti problemi kao što su krvarenje, fistula, perforacija, apscesi, posebno ako imate divertikulozu (bolest probavnog sustava koja zahvaća debelo crijevo).
English: Method of administration <Invented name> is administered by oral route.
Croatian: <Invented name> se primjenjuje oralnim putem.
English: • if you have heart problems such as cardiogenic shock, or left ventricular failure with low filling pressure or cardiac decompensation or shock.
Croatian: • ako imate problema sa srcem kao što je kardiogeni šok, popuštanje lijeve klijetke s niskim tlakom punjenja, zatajivanje srca ili šok.
English: Each tablet contains 20 mg nicorandil.
Croatian: Jedna tableta sadrži 20 mg nikorandila.
English: If advanced, ulcers may develop into perforation, fistula, or abscess formation.
Croatian: Ako ulkusi uznapreduju, mogu progredirati u perforaciju, fistulu ili apsces.
English: This leaflet was last revised in. [To be completed nationally]
Croatian: Ova uputa je zadnji puta revidirana u.
English: • Nicorandil may cause injuries to your gastrointestinal tract such as ulcers.
Croatian: • Nikorandil može uzrokovati oštećenja u Vašem probavnom sustavu, kao što su ulkusi.
English: In patients concomitantly receiving NSAIDs including acetylsalicylic acid for both cardiovascular prevention and anti-inflammatory doses, there is an increased risk for severe complications such as gastrointestinal ulceration, perforation and haemorrhage (see section 4.4).
Croatian: U bolesnika koji istovremeno primaju NSAIL-ove uključujući acetilsalicilatnu kiselinu za prevenciju kardiovaskularnih bolesti i u protuupalnim dozama povećan je rizik od ozbiljnih komplikacija kao što su gastrointestinalna ulceracija, perforacija i krvarenje (vidjeti dio 4.4).
English: • Flushing of the skin
Croatian: • Crvenilo na koži
English: This medicinal product is authorised in the Member States of the EEA under the following names: [See Annex I - To be completed nationally]
Croatian: Ovaj lijek je odobren u državama članicama Europskog ekonomskog prostora (EEA) pod sljedećim nazivima:
English: How to take <Invented name>
Croatian: Kako uzimati <Invented name>
English: If ulceration(s) develops, nicorandil should be discontinued (see section 4.8).
Croatian: Ako se razvije/u ulceracija/e, nikorandil treba ukinuti (vidjeti dio 4.8).
English: Not known (frequency cannot be estimated from the available data) • Double vision (diplopia).
Croatian: Nepoznato (učestalost se ne može procijeniti iz dostupnih podataka)
English: Patients taking acetylsalicylic acid or NSAIDs (Non Steroid Anti Inflammatory Drugs) concomitantly are at increased risk for severe complications such as gastrointestinal haemorrhage.
Croatian: Bolesnici koji istovremeno uzimaju acetilsalicilatnu kiselinu ili NSAIL (nesteroidne protuupalne lijekove) imaju povećan rizik od teških komplikacija kao što je gastrointestinalno krvarenje.
English: • Use of soluble guanylate cyclase stimulator(s) (such as riociguat) since it can lead to a serious fall in blood pressure (see section 4.5)
Croatian: • Primjena stimulatora topljive gvanilat-ciklaze (kao što je riocigvat) jer to može dovesti do jakog pada krvnog tlaka (vidjeti dio 4.5).
English: The only possible treatment is to stop nicorandil.
Croatian: Jedino moguće liječenje je prestanak uzimanja nikorandila.
English: Gastrointestinal perforations in context of concomitant use of nicorandil and corticosteroids have been reported.
Croatian: Gastrointestinalne perforacije su zabilježene u kontekstu istovremene primjene nikorandila i kortikosteroida.
English: The metabolism of nicorandil is not significantly affected by cimetidine (a CYP inhibitor), or rifampicin (a CYP3A4 inducer).
Croatian: Cimetidin (inhibitor CYP-a) ili rifampicin (induktor CYP3A4-a) ne utječu značajno na metabolizam nikorandila.
English: - Eye ulcerations
Croatian: Ulceracije oka
English: Furthermore, nicorandil has demonstrated a spasmolytic activity in both in vitro and in vivo studies and reverses coronary spasm induced by methacholine or noradrenalin.
Croatian: Nadalje, nikorandil u ispitivanjima in vitro i in vivo pokazuje spazmolitičku aktivnost te poništava koronarni spazam uzrokovan metakolinom i noradrenalinom.
English: Swallow the tablet (oral use).
Croatian: Progutajte tabletu (primjena kroz usta).
English: Do not take <Invented name>: • if you are allergic to nicorandil or any of the other ingredients of this medicine (listed in section
Croatian: • ako ste alergični na nikorandil ili bilo koji drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Concomitant use of soluble guanylate cyclase stimulator (such as riociguat) is contraindicated, since it can lead to a serious drop in blood pressure.
Croatian: Kontraindicirana je istovremena primjena sa stimulatorima topljive gvanilat-ciklaze (kao što je riocigvat) jer to može dovesti do jakog pada krvnog tlaka.
English: Nicorandil is principally metabolised in the liver by denitration in a series of compounds without cardiovascular activity.
Croatian: Nikorandil se uglavnom metabolizira denitracijom u jetri pri čemu nastaje niz spojeva koji ne djeluju na kardiovaskularni sustav.
English: Nicorandil may lower your blood pressure.
Croatian: Nikorandil Vam može sniziti krvni tlak.
English: Radioactivity passed through the placenta in pregnant rats after administration of radioactively marked nicorandil.
Croatian: Nakon primjene radioaktivno obilježenog nikorandila u trudnih ženki štakora radioaktivnost je prošla kroz placentu.
English: These results suggest that testicular toxicity by nicorandil is related to a sustained decrease in blood flow caused by reduction of cardiac output.
Croatian: Dobiveni podaci ukazuju na to da je toksično djelovanje nikorandila na testise povezano s trajnim smanjenjem protoka krvi uzrokovanim smanjenjem srčanog minutnog volumena.
English: A lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache.
Croatian: U bolesnika posebno sklonima glavobolji mogu se primjeniti manje početne doze od 5 mg dva puta dnevno.
English: Complications of gastrointestinal ulceration such as perforation, fistula, or abscess formation sometimes leading to gastrointestinal haemorrhage and weight loss have been reported (see section
Croatian: Zabilježene su komplikacije gastrointestinalnih ulceracija kao što su perforacija, fistula ili nastanak apscesa koji ponekad dovode do gastrointestinalnog krvarenja i gubitka tjelesne težine (vidjeti dio 4.4).
English: <Invented name> contains a medicine called nicorandil.
Croatian: Što je <Invented name> i za što se koristi <Invented name> sadrži lijek pod nazivom nikorandil.
English: • Red, itchy, swollen or watery eyes (conjunctivitis)
Croatian: • Crvene, otečene, suzne oči koje svrbe (konjuktivitis)
English: Talk straight away to your doctor if you experience any of the following: Nicorandil may cause injuries to your gastrointestinal tract such as ulcers in the mouth, tongue, stomach, guts (small and large), back passage.
Croatian: Nikorandil može uzrokovati oštećenja u Vašem probavnom sustavu kao što su ulkusi u ustima, na jeziku, u želucu, crijevu (tankom i debelom), rektumu.
English: Rash, pruritus Angioedema, Skin and mucosal ulcerations (mainly peri-anal ulcerations, genital ulcerations and parastomal ulcerations) (see section
Croatian: Angioedem, ulceracije na koži i sluznici (uglavnom perianalne, genitalne i parastomalne ulceracije) (vidjeti dio 4.4)
English: The most common adverse reaction reported in clinical trials is headache occurring in more than 30% of patients, particularly in the first days of treatment and responsible of most of study withdrawal.
Croatian: Najčešća nuspojava zabilježena u kliničkim ispitivanjima bila je glavobolja koja se pojavila u više od 30%
English: Nicorandil should be used with care in combination with other medical products that may increase potassium levels, especially in patients with moderate to severe renal impairment (see sections 4.5 and 4.8).
Croatian: Nikorandil treba pažljivo primjenjivati u kombinaciji s drugim lijekovima koji mogu povisiti razine kalija, posebno u bolesnika s umjerenim do teškim oštećenjem bubrega (vidjeti dijelove 4.5 i 4.8).
English: Mouth ulcer
Croatian: Ulkus u ustima
English: Caution is advised if nicorandil is used in combination with other medicinal products with blood pressure lowering effect (see section 4.5 and 4.8).
Croatian: Savjetuje se oprez ako se nikorandil primjenjuje u kombinaciji s drugim lijekovima s učinkom snižavanja krvnog tlaka (vidjeti dio 4.5 i 4.8).
English: DATE OF FIRST AUTHORISATION: RENEWAL OF THE AUTHORISATION [To be completed nationally]
Croatian: DATUM PRVOG ODOBRENJA/DATUM OBNOVE ODOBRENJA
English: • Hypovolaemia
Croatian: • Hipovolemija.
English: In addition, the following adverse reactions have been reported with different frequencies in the IONA (Impact of Nicorandil in Angina) study, where nicorandil has been used on top of standard therapy in patients with stable angina and at high risk of cardiovascular events (see section 5.1).
Croatian: Impact of Nicorandil in Angina) u kojem je nikorandil primijenjen uz standardnu terapiju u bolesnika sa stabilnom anginom i visokim rizikom od kardiovaskularnih događaja, zabilježene su sljedeće nuspojave s različitom učestalošću (vidjeti dio 5.1).
English: It is not known whether nicorandil passes in human milk.
Croatian: Nije poznato prelazi li nikorandil u majčino mlijeko.
English: Ikorel and associated names (see Annex I) 10 mg tablets Dancor and associated names (see Annex I) 10 mg tablets Ikorel and associated names (see Annex I) 20 mg tablets] Dancor and associated names (see Annex I) 20 mg tablets
Croatian: Ikorel i pridružena imena (vidjeti Dodatak I) 20 mg tablete Dankor i pridružena imena (vidjeti Dodatak I) 20 mg tablete
English: Marketing Authorisation Holder and Manufacturer [See Annex I - To be completed nationally]
Croatian: Nositelj odobrenja za stavljanje gotovog lijeka u promet i proizvođač [Vidjeti Dodatak I - ispunjava država članica]
English: • a rapid phase with a half-life of 1 hour approximately, representing 96% of the plasma exposure;
Croatian: Plazmatska koncentracija opada u dvije faze: - brzoj fazi s poluživotom od otprilike 1 sat, koja obuhvaća 96% plazmatske izloženosti; - sporoj eliminacijskoj fazi koja nastupa otprilike 12 sati nakon oralne primjene 20 mg bid.
English: Histopathological changes of the testes (diminished spermatogenic cells) were determined in repeat dose toxicity studies.
Croatian: U ispitivanju toksičnosti ponovljenih doza uočene su histopatološke promjene testisa (nestanak stanica spermatogenetske loze).
English: Very rare conjunctivitis, conjunctival ulcer and corneal ulcer have been reported with nicorandil.
Croatian: Vrlo rijetko je uz nikorandil zabilježen konjuktivitis te konjunktivalni i kornealni ulkus.
English: Do not swallow drying agent.
Croatian: Nemojte progutati sredstvo za sušenje.
English: It possesses a potassium-channel opening effect.
Croatian: Djeluje tako što otvara kalijske kanale.
English: The frequencies of adverse reactions reported with nicorandil are summarised in the following table by system organ class (in MedDRA) and by frequency.
Croatian: Učestalosti nuspojava zabilježenih s nikorandilom sažeto su prikazane u sljedećoj tablici prema MedDRA klasifikaciji organskih sustava i prema učestalosti.
English: Caution is advised when nicorandil is used in combination with other medical products that may increase potassium levels (see sections 4.4 and 4.8).
Croatian: Preporučuje se oprez kada se nikorandil primjenjuje u kombinaciji s drugim lijekovima koji mogu povisiti razine kalija (vidjeti dio 4.4 i 4.8).
English: Corneal ulcer, conjunctival ulcer, conjunctivitis (see section
Croatian: Ulceracija rožnice, ulceracija spojnice, konjunktivitis (vidjeti dio 4.4)
English: The metabolism of nicorandil appears not to be significantly modified by cimetidine or rifampicine, respectively an inhibitor and an inducer of liver microsomal mixed-function oxidases.
Croatian: Čini se da cimetidin ili rifampicin (inhibitor odnosno induktor mikrosomalnih oksidaza s mješovitim funkcijama u jetri) ne mijenjaju značajno metabolizam nikorandila.
English: What <Invented name> is and what it is used for
Croatian: Što se nalazi u ovoj uputi: Što je lijek <Invented name> i za što se koristi
English: Uncommon (may affect up to 1 in 100 people) • Decrease in blood pressure.
Croatian: Vrlo rijetko (mogu se javiti u do 1 na 10 000 osoba) • Visoke razine kalija u krvi (hiperkalijemija)
English: Patients with liver and/or renal impairment There are no special dosage requirements for patients with liver and/or renal impairment.
Croatian: Nema posebnih preporuka za doziranje u bolesnika s oštećenjem jetre i/ili bubrega.
English: Severe hyperkalaemia has been very rarely reported with nicorandil.
Croatian: Vrlo rijetko je uz nikorandil zabilježena teška hiperkalijemija.
English: Gastrointestina l ulcerations (stomatitis, aphtosis, mouth ulcer, tongue ulcer, small intestinal ulcer, large intestinal ulcer, anal ulcer) (see below and section 4.4)
Croatian: Gastrointestinalne ulceracije (stomatitis, afte, ulkus u ustima, ulkus na jeziku, ulkus u tankom crijevu, ulkus u debelom crijevu,
English: • Medicines that increase blood potassium levels.
Croatian: • Lijekove koji povisuju razinu kalija u krvi.
English: • Cornea injuries
Croatian: • Oštećenja rožnice
English: • If you have low blood potassium level and your doctor has prescribed potassium supplements,
Croatian: • Ako imate nisku razinu kalija u krvi i Vaš liječnik Vam je propisao nadomjestak kalija, ili ako patite od oštećenja bubrega ili uzimate drugi lijek koji može povisiti razine kalija.
English: If ulceration(s) develops, nicorandil should be permanently discontinued (see section 4.8).
Croatian: nikorandil treba trajno ukinuti (vidjeti dio 4.8).
English: You can also report side effects directly via the national reporting system Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Croatian: Nuspojave možete prijaviti izravno putem nacionalnog sustava za prijavu nuspojava navedenog u Dodatku V.
English: This results in an increased pooling in capacitance vessels with a decrease in preload.
Croatian: Rezultat je povećano nakupljanje krvi u venskom bazenu i smanjenje predopterećenja.
English: Gastrointestina l haemorrhage (see section
Croatian: Gastrointestinalno krvarenje (vidjeti dio 4.4)
English: Impairment of Fertility
Croatian: Oštećenje plodnosti
English: In addition, serious adverse reactions including ulcerations and their complications (see section 4.4) were reported during the post marketing surveillance of nicorandil.
Croatian: uključujući ulceracije i njihove komplikacije (vidjeti dio 4.4).
English: • Use of phosphodiesterase 5 inhibitors, since this can lead to a serious drop in blood pressure
Croatian: • Primjena inhibitora fosfodiesteraze 5 jer to može dovesti do jakog pada krvnog tlaka (vidjeti dio 4.5).
English: • Being sick (vomiting)
Croatian: • Dvoslike (diplopija).
English: • Acute pulmonary oedema
Croatian: • Akutni plućni edem.
English: QUALITATIVE AND QUANTITAVE COMPOSITION [To be completed nationally]
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV
English: How to store <Invented name> Contents of the pack and other information
Croatian: Sadržaj pakiranja i druge informacije
English: • Dizziness
Croatian: • Povraćanje
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER [See Annex I - To be completed nationally]
Croatian: 11. IME I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: Gastrointestinal ulcerations, skin and mucosal ulcerations have been reported with nicorandil (see section 4.8).
Croatian: 4.4 Posebna upozorenja i mjere opreza pri uporabi Ulceracije: uz nikorandil su zabilježene gastrointestinalne ulceracije te ulceracije na koži i sluznici (vidjeti dio 4.8).
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 10 mg nicorandil.
Croatian: Jedna tableta sadrži 10 mg nikorandila.
English: Other side effects include: Very common (may affect more than 1 in 10 people)
Croatian: Vrlo često (mogu se javiti u više od 1 na 10 osoba)
English: Gastrointestinal haemorrhage secondary to gastrointestinal ulceration has been reported with nicorandil.
Croatian: Uz nikorandil je zabilježeno i gastrointestinalno krvarenje nastalo kao posljedica gastrointestinalnih ulceracija.
English: Cutaneous vasodilatio n with flushing
Croatian: Vazodilatacija u koži s crvenilom
English: Symptoms
Croatian: Apsorpcija
English: Concurrent use of nicorandil and phosphodiesterase 5 inhibitors, e.g. sildenafil, tadalafil, vardenafil, is contraindicated, since it can lead to a serious drop in blood pressure (synergic effect).
Croatian: tadalafila, vardenafila, jer može dovesti do jakog pada krvnog tlaka (sinergistički učinak).
English: Very rare (may affect up to 1 in 10,000 people)
Croatian: Manje često (mogu se javiti u do 1 na 100 osoba)
English: Frequencies are defined as: Very common
Croatian: Druge nuspojave uključuju:
English: How to store <Invented name>
Croatian: Kako čuvati lijek <Invented name>
English: This belongs to a group of medicines called ‘potassium channel activators'.
Croatian: On pripada skupini lijekova koji se nazivaju
English: Stop taking straight away nicorandil and talk to your doctor if you experience any of the following:
Croatian: Ako primijetite bilo što od sljedećeg, odmah prestanite uzimati nikorandil i obratite se svome liječniku:
English: nicorandil
Croatian: nikorandil
English: EU/2/04/044/014 Aivolsin 625 mg/g Granules for use in drinking water
Croatian: EU/2/04/044/013 Aivlosin 42,5 mg/g Prašak za peroralnu primjenu
English: Meat and offal:2 days Eggs : zero days (chickens) Turkeys:Not authorised for laying birds.
Croatian: Meso i jestive iznutrice: 2 dana Jaja: nula dana (pilići)
English: 42.5 mg/g 20 kg Meat and offal 2 days
Croatian: 42,5 mg/g 20 kg Meso i jestive iznutrice: 2 dana
English: 625 mg/g 400 g Meat and offal: 2 days Eggs: zero days (chickens) Turkeys:Not authorised for laying birds.
Croatian: 400 g Meso i jestive iznutrice: 2 dana Jaja: nula dana (pilići)
English: Meat and offal 2 days
Croatian: Meso i jestive iznutrice: 1 dan
English: Further care must be taken for up to six months.
Croatian: Daljnja skrb mora se provoditi do šest mjeseci.
English: If a second treatment is necessary, this should take place at least four weeks later.
Croatian: Ako je potreban drugi tretman, on se mora provesti nakon najmanje četiri tjedna.
English: The dose is 0.15 mg per kilogram body weight.
Croatian: Preporučena doza je 0,15 mg po kilogramu tjelesne težine.
English: The full EPAR for Foscan can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Croatian: Cjelovito Europsko javno izvješće o ocjeni dokumentacije o lijeku (EPAR) može se naći na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: Other information about Foscan
Croatian: Druge informacije o lijeku Foscan
English: In all studies, the response was assessed between 12 and 16 weeks after the final treatment with Foscan, but Foscan was not compared with any other treatment.
Croatian: U svim ispitivanjima odgovor se procjenjivao između 12 i 16 tjedana nakon završnog tretmana lijekom Foscan, no Foscan se nije uspoređivao ni sa kojim drugim liječenjem.
English: However, in the study looking at improving symptoms of advanced head and neck cancer, 28 (22%) of the 128 patients assessed had a significant improvement in their most troubling symptom.
Croatian: Međutim, u ispitivanju u kojem se promatralo ublažavanje simptoma uznapredovalog karcinoma glave i vrata, kod 28 (22%) od 128 procijenjenih ispitanika primijećeno je značajno poboljšanje njihovog najtežeg simptoma.
English: Treatment with Foscan is a two-step process: the medicine is given first, and then it is activated using a laser.
Croatian: Liječenje lijekom Foscan postupak je od dva koraka: prvo se daje lijek, a potom se on aktivira pomoću lasera.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Foscan on 24 October 2001.
Croatian: Europska komisija izdaje odobrenje za stavljanje u promet koje za Foscan vrijedi na prostoru Europske unije od 24. listopada 2001.
English: This kills the cells by reacting with and destroying their components, such as their proteins and DNA.
Croatian: To ubija stanice reagirajući i uništavajući njihove sastavnice, kao što su njihove bjelančevine i DNK.
English: Each area of the tumour should be illuminated only once during each treatment.
Croatian: Svako područje tumora mora se obasjati laserom samo jednom tijekom svakog tretmana.
English: Four days later, the entire surface of the tumour and the surrounding 0.5 cm margin is illuminated with light from a laser at a specific wavelength, using a fibre-optic cable.
Croatian: Četiri dana kasnije cijela površina tumora i 0,5 cm ruba koji ga okružuje osvjetljava se laserskim svjetlom određene valne duljine koristeći optički kabel.
English: Around a quarter of the patients in this study also had a reduction in tumour size.
Croatian: Kod otprilike četvrtine ispitanika u ispitivanju došlo je i do smanjenja tumora.
English: Patients receiving Foscan should take care to avoid exposure to sun light or bright light for two weeks after injection to avoid skin burns.
Croatian: Bolesnici koji primaju Foscan moraju paziti da izbjegavaju izlaganje sunčevoj svjetlosti ili jakom svjetlu dva tjedna nakon injekcije kako bi se izbjegle opekline kože.
English: When it is illuminated with laser light of a specific wavelength, temoporfin is activated and reacts with oxygen in the cells to create a highly reactive and toxic type of oxygen.
Croatian: Kad se osvijetli laserskom svjetlošću specifične valne duljine, temoporfin se aktivira i reagira s kisikom u stanicama kako bi stvorio visoko reaktivan toksični tip kisika.
English: The medicine is given by an indwelling intravenous cannula (a thin tube permanently inserted into a vein) as a single slow injection over at least six minutes.
Croatian: Lijek se daje putem trajne intravenske kanile (tanka cjevčica koja je trajno umetnuta u venu) kao jednokratna spora injekcija kroz najmanje šest minuta.