FrancophonIA/ELRC3.0 huggingface dataset:
English: These effects were observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use.
Croatian: Ti su učinci zabilježeni tek pri razinama izloženosti koje se smatraju dovoljno većima od maksimalne izloženosti lijeku u ljudi, što ukazuje na malen značaj za kliničku primjenu.
English: New or worse heart or blood vessel (cardiovascular) problems have been reported primarily in people who already have cardiovascular problems.
Croatian: Novonastale tegobe ili pogoršanje postojećih tegoba sa srcem ili krvnim žilama (kardiovaskularne tegobe) prijavljene su prvenstveno u osoba koje su već imale kardiovaskularne tegobe.
English: It has been shown in clinical trials that taking all doses of your medicine at the appropriate times and for the recommended duration of treatment described above will increase your chances of stopping smoking.
Croatian: Klinička ispitivanja pokazala su da uzimanje svih doza lijeka u pravo vrijeme i tijekom prethodno opisanoga preporučenog razdoblja liječenja povećava izglede za prestanak pušenja.
English: Absorption is virtually complete after oral administration and systemic availability is high.
Croatian: Apsorpcija je nakon peroralne primjene gotovo potpuna, a sustavna raspoloživost visoka.
English: Not known o Transient loss of consciousness
Croatian: o prolazni gubitak svijesti
English: CI=confidence interval; N=number of subjects randomised; n=the number of subjects who, at each visit from weeks 9 to 12 (inclusive), reported no smoking and no use of other nicotine-containing products since the last study visit/last contact (on the Nicotine Use Inventory) and at any of these visits were confirmed to have quit based on urine cotinine test.
Croatian: CI=interval pouzdanosti; N=broj randomiziranih ispitanika; n=broj ispitanika koji su, pri svakom posjetu od 9. do 12. tjedna (uključujući i navedene tjedne), prijavili da nisu pušili niti koristili druge proizvode koji sadrže nikotin od zadnjeg posjeta u ispitivanju/zadnjeg kontakta (u upitniku o korištenju nikotina) i za koje je potvrđeno da su prestali pušiti na temelju testa urina na kotinin tijekom bilo kojeg od ovih posjeta.
English: During treatment plus 30 days MACE, n (%)
Croatian: Tijekom liječenja plus 30 dana MACE, n (%)
English: The individual components of the endpoint are also shown.
Croatian: Prikazane su i pojedine komponente ishoda.
English: Subjects were instructed to reduce the number of cigarettes smoked by at least 50 percent by the end of the first four weeks of treatment, followed by a further 50 percent reduction from week four to week eight of treatment, with the goal of reaching complete abstinence by 12 weeks.
Croatian: Ispitanici su primili uputu da smanje broj popušenih cigareta za najmanje 50 posto do kraja prva četiri tjedna liječenja, a nakon toga još dodatno za 50% od četvrtog do osmog tjedna liječenja, s ciljem dostizanja potpune apstinencije do 12. tjedna.
English: Varenicline vs NRT
Croatian: Vareniklin naspram NRT
English: Because elderly patients are more likely to have decreased renal function, prescribers should consider the renal status of an elderly patient.
Croatian: Budući da u starijih bolesnika postoji veća vjerojatnost smanjene bubrežne funkcije, liječnik propisivač treba uzeti u obzir status bubrežne funkcije starijeg bolesnika.
English: CHAMPIX, (n = 248) Placebo, (n = 251) Odds ratio (CHAMPIX vs.
Croatian: CHAMPIX (n = 248) Placebo (n=251) Omjer izgleda (CHAMPIX naspram placeba)
English: Of all subjects treated in the parent study, 1749 (21.7%) had a medium CV risk and 644 (8.0%) had a high CV risk, as defined by Framingham score.
Croatian: Od svih ispitanika liječenih u ishodišnom ispitivanju, 1749 (21,7%) je imalo srednji KV rizik i 644 (8,0%) je imalo visok KV rizik, definirano prema Framinghamovoj ljestvici.
English: * Of these, one patient in each treatment arm reported suicidal behaviour ** Patients with events up to 30 days after treatment; % are not weighted by study # RR of incidence rates per 100 patient years
Croatian: * Od tih, po jedan bolesnik u svakoj skupini liječenja prijavio je suicidalno ponašanje ** Bolesnici s događajima do 30 dana nakon liječenja; % nisu ponderirani u ispitivanju # RR stopa incidencija na 100 bolesnik godina
English: As these skin reactions can be life threatening, patients should discontinue treatment at the first sign of rash or skin reaction and contact a healthcare provider immediately.
Croatian: Budući da te kožne reakcije mogu ugroziti život, bolesnici moraju prekinuti liječenje na prvi znak osipa ili kožne reakcije i odmah se obratiti zdravstvenom radniku.
English: There was one completed suicide, which occurred during treatment in a subject treated with placebo in the non-psychiatric cohort.
Croatian: Postojalo je jedno ostvareno samoubojstvo koje se dogodilo tijekom liječenja u ispitanika koji je primao placebo u nepsihijatrijskoj kohorti.
English: * NEC = Not Elsewhere Classified Counts (percentages) corresponds to the number of patients reporting the event
Croatian: Not Elsewhere Classified) Brojevi (postoci) odgovaraju broju bolesnika koji su prijavili događaj
English: Patients taking CHAMPIX should be instructed to notify their doctor of new or worsening cardiovascular symptoms and to seek immediate medical attention if they experience signs and symptoms of myocardial infarction or stroke (see section 5.1).
Croatian: Bolesnike koji uzimaju CHAMPIX mora se upozoriti da obavijeste svoga liječnika o pojavi novih ili pogoršanju postojećih kardiovaskularnih simptoma te da odmah zatraže medicinsku pomoć ako primijete znakove i simptome infarkta miokarda ili moždanog udara (vidjeti dio 5.1).
English: Examples include theophylline (a medicine to treat breathing problems), warfarin (a medicine to reduce blood clotting), and insulin (a medicine to treat diabetes).
Croatian: Primjeri uključuju teofilin (lijek za liječenje dišnih tegoba), varfarin (lijek za smanjenje zgrušavanja krvi) i inzulin (lijek za liječenje šećerne bolesti).
English: The key results are summarised in the following table:
Croatian: Ključni rezultati sažeti su u sljedećoj tablici:
English: If you have severe kidney disease you should avoid taking cimetidine (a medicine used for gastric problems) at the same time as CHAMPIX as this may cause increased blood levels of CHAMPIX.
Croatian: Ako imate tešku bolest bubrega, morate izbjegavati uzimati cimetidin (lijek za želučane tegobe) istodobno s lijekom CHAMPIX, jer to može dovesti do povećanja razine lijeka CHAMPIX u krvi.
English: Patients should reduce smoking during the first 12 weeks of treatment and quit by the end of that treatment period.
Croatian: Bolesnici moraju smanjiti pušenje tijekom prvih 12 tjedana liječenja i prestati do kraja razdoblja liječenja.
English: The occurrence of detected suicide was rare during the three months after patients initiated any drug treatment (two cases in 31,260 varenicline users and six cases in 81,545 NRT users).
Croatian: Pojavnost otkrivenog suicida bila je rijetka tijekom tri mjeseca nakon što su bolesnici započeli liječenje bilo kojim lijekom (dva slučaja na 31 260 korisnika vareniklina i šest slučajeva na 81 545 korisnika nikotinske zamjenske terapije).
English: Blisters: Store below 30°C HDPE Bottle: This medicinal product does not require any special storage conditions
Croatian: Blisteri: Čuvati na temperaturi ispod 30°C HDPE bočica: Lijek ne zahtijeva posebne uvjete čuvanja.
English: Varenicline undergoes minimal metabolism with 92% excreted unchanged in the urine and less than 10% excreted as metabolites.
Croatian: Vareniklin se minimalno metabolizira, pa se 92% lijeka izlučuje mokraćom u nepromijenjenu obliku, a manje od 10% se izlučuje u obliku metabolita.
English: As a precautionary measure, it is preferable to avoid the use of varenicline during pregnancy (see section 5.1).
Croatian: Kao mjera opreza, preporučuje se izbjegavati primjenu vareniklina tijekom trudnoće (vidjeti dio 5.1).
English: The primary endpoint for CHAMPIX demonstrated statistical superiority to bupropion and placebo.
Croatian: Primarna mjera ishoda za CHAMPIX pokazala je statističku superiornost ovoga lijeka u odnosu na bupropion i placebo.
English: It is preferable to avoid the use of CHAMPIX while you are pregnant.
Croatian: Poželjno je izbjegavati primjenu lijeka CHAMPIX tijekom trudnoće.
English: Dosing should begin at 0.5 mg once daily for the first 3 days then increased to 1 mg once daily.
Croatian: Liječenje treba započeti dozom od 0,5 mg jedanput na dan tijekom prva 3 dana, a zatim je povećati na 1 mg jedanput na dan.
English: The pharmacokinetics of varenicline in elderly patients with normal renal function (aged 65-75 years) is similar to that of younger adult subjects (see section 4.2).
Croatian: Farmakokinetika vareniklina u starijih bolesnika s normalnom funkcijom bubrega (u dobi 65-75 godina) slična je onoj u mlađih odraslih ispitanika (vidjeti dio 4.2).
English: Subjects with cardiovascular disease
Croatian: Ispitanici s kardiovaskularnom bolešću
English: You should be aware of the possible emergence of serious neuropsychiatric symptoms, such as agitation, depressed mood, or changes in behaviour during a quit attempt with or without CHAMPIX and you should contact a doctor or pharmacist if you experience such symptoms.
Croatian: Morate biti svjesni mogućeg pojave ozbiljnih neuropsihijatrijskih simptoma poput uznemirenosti, depresivnog raspoloženja ili promjena u ponašanju tijekom pokušaja prestanaka pušenja s lijekom CHAMPIX ili bez njega i morate se obratiti liječniku ili ljekarniku ako se pojave ovakvi simptomi.
English: Furthermore since metabolism of varenicline represents less than 10% of its clearance, active substances known to affect the cytochrome P450 system are unlikely to alter the pharmacokinetics of varenicline (see section 5.2) and therefore a dose adjustment of CHAMPIX would not be required.
Croatian: Nadalje, budući da metabolizam vareniklina predstavlja manje od 10% njegova klirensa, nije vjerojatno da bi djelatne tvari koje utječu na sustav citokroma P450 mogle izmijeniti farmakokinetiku vareniklina (vidjeti dio 5.2) pa stoga neće biti potrebno prilagođavati dozu lijeka CHAMPIX.
English: Smoking cessation, with or without pharmacotherapy, has been associated with exacerbation of underlying psychiatric illness (e.g. depression).
Croatian: Odvikavanje od pušenja, uz primjenu farmakoterapije ili bez nje, povezuje se s pogoršanjem osnovne psihijatrijske bolesti (npr. depresije).
English: Potentially life-threatening skin rashes (Stevens-Johnson syndrome and Erythema Multiforme) have been reported with the use of CHAMPIX.
Croatian: Potencijalno po život opasni kožni osipi (Stevens-Johnsonov sindrom i multiformni eritem) prijavljeni su uz primjenu lijeka CHAMPIX.
English: The key efficacy results are summarised in the following table:
Croatian: Ključni rezultati djelotvornosti sažeti su u sljedećoj tablici:
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 26 September 2006
Croatian: Datum prvog odobrenja: 26. rujna 2006.
English: Nicotine competes for the same human α4β2 nAChR binding site for which varenicline has higher affinity.
Croatian: Nikotin se u ljudi natječe za isto vezno mjesto α4β2 nAChR za koje vareniklin ima veći afinitet.
English: In patients treated with the recommended dose of 1 mg twice daily following an initial titration period the adverse event most commonly reported was nausea (28.6%).
Croatian: U bolesnika liječenih preporučenom dozom od 1 mg dvaput na dan nakon početnog razdoblja titracije najčešće prijavljena nuspojava bila je mučnina (28,6%).
English: Of the 55 patients who reported suicidal ideation or behaviour, 48 (24 varenicline, 24 placebo) were from the two trials that enrolled patients with a history of schizophrenia/ schizoaffective disorder, or of depression.
Croatian: Od 55 bolesnika koji su prijavili suicidalne ideacije ili ponašanje, 48 (24 na vareniklinu, 24 na placebu) ih je bilo iz dva ispitivanja koja su uključivala bolesnike sa shizofrenijom/shizoafektivnim poremećajem ili depresijom u anamnezi.
English: If you are not able or willing to quit smoking straight away, you should reduce smoking during the first 12 weeks of treatment and quit by the end of that treatment period.
Croatian: Ako ne možete ili ne želite odmah prestati pušiti, trebali biste smanjiti pušenje tijekom prvih 12 tjedana liječenja i prestati do kraja razdoblja liječenja.
English: For some people, stopping smoking with or without treatment has been associated with an increased risk of experiencing changes in thinking or behaviour, feelings of depression and anxiety and can be associated with a worsening of psychiatric disorder.
Croatian: U nekih se ljudi prestanak pušenja, uz liječenje ili bez njega, povezuje s povećanim rizikom od promjena razmišljanja ili ponašanja, osjećajima depresije i tjeskobe, a može biti povezan i s pogoršanjem psihičkog poremećaja bolesti.
English: Neuropsychiatric symptoms
Croatian: Neuropsihijatrijski simptomi
English: Physiological changes resulting from smoking cessation, with or without treatment with CHAMPIX, may alter the pharmacokinetics or pharmacodynamics of some medicinal products, for which dosage adjustment may be necessary (examples include theophylline, warfarin and insulin).
Croatian: Fiziološke promjene koje nastaju kao posljedica prestanka pušenja, uz liječenje lijekom CHAMPIX ili bez njega, mogu izmijeniti farmakokinetiku ili farmakodinamiku nekih lijekova, čiju će dozu stoga možda trebati prilagoditi (primjeri uključuju teofilin, varfarin i inzulin).
English: If you develop a rash or if your skin starts to peel or blister you should stop taking CHAMPIX and seek emergency medical help.
Croatian: Ako razvijete osip ili Vam se koža počne guliti ili Vam nastaju mjehurići, morate prestati uzimati CHAMPIX i potražiti hitnu liječničku pomoć.
English: A meta-analysis of 18 double-blind, randomised, placebo-controlled clinical trials was conducted to assess the neuropsychiatric safety of varenicline.
Croatian: Metaanaliza 18 dvostruko slijepih, randomiziranih, placebom kontroliranih kliničkih ispitivanja provedena je da bi se procijenila neuropsihijatrijska sigurnost vareniklina.
English: Bottle: This medicine does not require any special storage conditions.
Croatian: Bočica: Lijek ne zahtijeva posebne uvjete čuvanja.
English: What you need to know before you take CHAMPIX
Croatian: Što morate znati prije nego što počnete uzimati CHAMPIX
English: This meta-analysis included one trial (N=127) in patients with a history of schizophrenia or schizoaffective disorder and another trial (N=525) in patients with a history of depression.
Croatian: Ta metaanaliza uključivala je jedno ispitivanje (N=127) s bolesnicima koji imaju shizofreniju ili shizoafektivni poremećaj u anamnezi i drugo ispitivanje (N=525) s bolesnicima koji imaju depresiju u anamnezi.
English: Psychiatric Cohort
Croatian: Psihijatrijska kohorta
English: CHAMPIX should be used cautiously in patients with a history of seizures or other conditions that potentially lower the seizure threshold.
Croatian: CHAMPIX treba s oprezom primijeniti u bolesnika s napadajima u anamnezi ili kod drugih stanja koja potencijalno smanjuju prag napadaja.
English: Smoking cessation itself may result in changes to warfarin pharmacokinetics (see section 4.4).
Croatian: Prestanak pušenja sam po sebi može dovesti do promjena u farmakokinetici varfarina (vidjeti dio 4.4).
English: In the varenicline group compared to placebo, a higher proportion of subjects reported suicidal ideation or behaviour prior to enrolment (lifetime history) and after the end of active treatment period (on Days 33 to 85 after the last dose of treatment).
Croatian: U skupini koja je primala vareniklin je u odnosu na skupinu koja je primala placebo veći broj ispitanika prijavio suicidalne ideacije ili ponašanje prije uključivanja u ispitivanje (cjeloživotna anamneza) i nakon završetka razdoblja aktivnog liječenja (od 33. do 85. dana nakon posljednje doze liječenja).
English: There have also been reports of severe skin reactions including Erythema Multiforme (a type of rash) and Stevens-Johnson Syndrome (a serious illness with blistering of the skin, mouth, around the eyes or genitals) and serious allergic reactions including angioedema (swelling of the face, mouth, or throat).
Croatian: Također postoje izvješća o teškim kožnim reakcijama uključujući multiformni eritem (vrsta osipa) i Stevens-Johnsonov sindrom (ozbiljnu bolest s mjehurićima na koži, ustima, oko očiju ili genitalija) te ozbiljne alergijske reakcije uključujući angioedem (oticanje lica, usta ili grla).
English: Do not use this medicine after the expiry date which is stated on the card packaging or carton after EXP.
Croatian: Ovaj se lijek ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kartonskom ovitku ili kutiji iza oznake „Rok valjanosti“ ili „EXP“.
English: Patients who are motivated to quit and who did not succeed in stopping smoking during prior CHAMPIX therapy, or who relapsed after treatment, may benefit from another quit attempt with CHAMPIX (see section 5.1).
Croatian: Bolesnici koji su motivirani prestati pušiti, ali nisu u tome uspjeli tijekom prethodne terapije lijekom CHAMPIX, ili koji su ponovno počeli pušiti nakon liječenja, mogu imati koristi od još jednog pokušaja prestanka pušenja s lijekom CHAMPIX (vidjeti dio 5.1).
English: UNIQUE IDENTIFIER - 2D BARCODE Not Applicable
Croatian: 17. JEDINSTVENI IDENTIFIKATOR - 2D BARKOD
English: These trials included the 5 trials described above that used the C-SSRS, and a total of 8521 patients (5072 varenicline, 3449 placebo), some of which had psychiatric conditions.
Croatian: Ta su ispitivanja uključivala 5 ispitivanja opisana gore u tekstu u kojima je upotrijebljen C-SSRS i ukupno 8521 bolesnika (5072 na vareniklinu, 3449 na placebu), od kojih su neki bili sa psihijatrijskim stanjima.
English: Should you experience adverse effects that you cannot tolerate your doctor may decide to reduce your dose temporarily or permanently to 0.5 mg twice daily.
Croatian: Ako imate nuspojave koje ne možete podnijeti, Vaš liječnik može odlučiti da Vam privremeno ili trajno smanji dozu na 0,5 mg dvaput na dan.
English: The efficacy and safety of varenicline was evaluated in a randomised, double-blind, placebo-controlled study of 312 patients aged 12 to 19 years, who smoked an average of at least 5 cigarettes per day during the 30 days prior to recruitment, and had a score of at least 4 on the Fagerstrom Test for Nicotine Dependence scale.
Croatian: Djelotvornost i sigurnost vareniklina procijenjena je u randomiziranom, dvostruko slijepom, placebom kontroliranom ispitivanju na 312 bolesnika u dobi od 12 do 19 godina koji su u prosjeku pušili najmanje 5 cigareta na dan tijekom 30 dana prije regrutiranja i imali rezultat od najmanje 4 na ljestvici Fagerstromovog testa za procjenu ovisnosti o nikotinu.
English: Varenicline (N=5072)
Croatian: Vareniklin (N=5072)
English: CHAMPIX is a medicine which is used in adults to help them stop smoking.
Croatian: CHAMPIX je lijek koji se koristi u odraslih kao pomoć kod prestanka pušenja.
English: Ísland Icepharma hf.
Croatian: Icepharma hf.
English: There were rare reports of life-threatening angioedema requiring urgent medical attention due to respiratory compromise.
Croatian: Rijetko je prijavljen po život opasan angioedem koji iziskuje hitnu liječničku pomoć zbog ugroženosti disanja.
English: The rates of events in the composite endpoint were low across all treatment groups and were similar or lower for each of the active treatments compared to placebo.
Croatian: Stope događaja u kompozitnom ishodu bile su niske u svim liječenim skupinama i bile su slične ili niže za svako liječenje djelatnom tvari u usporedbi s placebom.
English: 12-week Treatment Initiation Pack containing:
Croatian: Pakiranje za početak 12-tjednog liječenja koje sadrži:
English: Weeks 3 - 12 Day 15end of treatment
Croatian: 3. - 12. tjedan 15. dankraj liječenja
English: Study 2 (n=1023) 4W CQR CA Wk 9-52 4W CQR CA Wk 9-52
Croatian: Ispitivanje 2 (n=1023) 4W CQR CA 9.-52. tjedan 4W CQR CA 9.-52. tjedan
English: One outer carton containing:
Croatian: Jedna vanjska kutija sadrži:
English: The CHAMPIX safety profile in this study was consistent with that of pre-marketing studies.
Croatian: Sigurnosni profil lijeka CHAMPIX u ovom ispitivanju bio je u skladu s onim iz ispitivanja prije stavljanja u promet.
English: There are limited clinical data on any potential interaction between alcohol and varenicline.
Croatian: Klinički podaci o mogućim interakcijama između alkohola i vareniklina su ograničeni.
English: When varenicline and transdermal NRT were co-administered to smokers for 12 days, there was a statistically significant decrease in average systolic blood pressure (mean 2.6 mmHg) measured on the final day of the study.
Croatian: Kad su vareniklin i transdermalna nikotinska zamjenska terapija primjenjivani istodobno tijekom 12 dana u pušača, došlo je do statistički značajnog smanjenja prosječnog sistoličkog krvnog tlaka (srednja vrijednost 2,6 mmHg) izmjerena na zadnji dan ispitivanja.
English: Subjects treated with CHAMPIX had a significantly higher Continuous Abstinence Rate compared with placebo; the key results are summarised in the following table:
Croatian: Ispitanici koji su primali lijek CHAMPIX imali su znatno višu stopu kontinuirane apstinencije u usporedbi s placebom; ključni rezultati sažeti su u sljedećoj tablici:
English: CHAMPIX was evaluated in a randomised, double-blind, placebo-controlled study of subjects with stable, cardiovascular disease (other than, or in addition to, hypertension) that had been diagnosed for more than 2 months.
Croatian: CHAMPIX je ispitan u randomiziranom, dvostruko slijepom, placebom kontroliranom ispitivanju u kojem su sudjelovali ispitanici sa stabilnom kardiovaskularnom bolešću (osim ili pored hipotenzije) koja je dijagnosticirana prije više od 2 mjeseca.
English: See below under ‘Other medicines and CHAMPIX' for further details.
Croatian: Za dodatne informacije vidjeti "Drugi lijekovi i CHAMPIX" u nastavku.
English: Clinical signs included swelling of the face, mouth (tongue, lips, and gums), neck (throat and larynx) and extremities.
Croatian: Klinički znakovi uključivali su oticanje lica, usta (jezik, usne i desni), vrata (grlo i ždrijelo) te ekstremiteta.
English: There are no clinical data on the effects of varenicline on fertility.
Croatian: Nema kliničkih podataka o učincima vareniklina na plodnost.
English: Heart symptoms
Croatian: Srčani simptomi
English: Renal elimination of varenicline is primarily through glomerular filtration along with active tubular secretion via the organic cationic transporter, OCT2 (see section 4.5).
Croatian: Bubrežna eliminacija vareniklina odvija se primarno glomerularnom filtracijom i aktivnom tubularnom sekrecijom putem organskog kationskog prijenosnika OCT2 (vidjeti dio 4.5).
English: Although there were no completed suicides, there was one suicidal attempt in a varenicline-treated subject whose lifetime history included several similar attempts.
Croatian: Iako nije izvršeno nijedno samoubojstvo, došlo je do pokušaja samoubojstva u jednog bolesnika liječenog vareniklinom koji je u anamnezi već imao nekoliko sličnih pokušaja.
English: Overall, there was no worsening of schizophrenia in either treatment group as measured by psychiatric scales and there were no overall changes in extra-pyramidal signs.
Croatian: Sveukupno nije došlo do pogoršanja shizofrenije niti u jednoj skupini, mjereno psihijatrijskim ljestvicama, a nije došlo ni do ukupnih promjena u ekstrapiramidnim znakovima.
English: What CHAMPIX is and what it is used for 2.
Croatian: Što je CHAMPIX i za što se koristi
English: You should then continue to take CHAMPIX 1 mg film-coated tablets twice daily for a further 12 weeks resulting in a total of 24 weeks of treatment.
Croatian: Zatim trebate nastaviti uzimati CHAMPIX filmom obložene tablete od 1 mg dvaput na dan tijekom sljedećih 12 tjedana, što rezultira s ukupno 24 tjedna liječenja.
English: In clinical studies in humans, varenicline showed low abuse potential.
Croatian: U kliničkim ispitivanjima s ljudima pokazalo se da vareniklin ima malen potencijal za zlouporabu.