FrancophonIA/ELRC3.0 huggingface dataset:
English: Ziagen oral solution also contains methyl parahydroxybenzoate and propyl parahydroxybenzoate which may cause allergic reactions (possibly delayed).
Slovenian: Zdravilo Ziagen peroralna raztopina vsebuje tudi metilparahidroksibenzoat in propilparahidroksibenzoat, ki lahko povzročata alergijske reakcije (lahko zapoznele).
English: A fertility study in the rat has shown that abacavir had no effect on male or female fertility.
Slovenian: Študija plodnosti pri podganah je pokazala, da abakavir ne vpliva na plodnost samcev in samic.
English: When changing back to a twice daily regimen, patients should take the recommended twice daily dose approximately 24 hours after the last once daily dose.
Slovenian: Bolniki, ki bodo prešli nazaj na režim odmerjanja dvakrat na dan, morajo vzeti odmerek približno 24 ur po zadnjem enkratnem dnevnem odmerku.
English: As a general rule, when deciding to use antiretroviral agents for the treatment HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, both animal data as well as clinical experience in pregnant women should be taken into account.
Slovenian: Kot splošno navodilo velja, da je treba upoštevati podatke na živalih, kot tudi izkušnje pri nosečnicah, kadar se odločamo o uporabi protiretrovirusnih učinkovin za zdravljenje okužbe z virusom HIV pri nosečnicah in posledično za zmanjšanje tveganja vertikalnega prenosa na novorojenčka.
English: Ziagen oral solution is clear to yellowish in colour which may turn into a brown colour over time with strawberry/banana flavouring.
Slovenian: Ziagen peroralna raztopina je bistra, rumenkaste barve, čez čas pa lahko postane rjava, in ima okus po jagodi/banani.
English: Adults, adolescents and children weighing at least 25 kg The usual dose of Ziagen is 600 mg (30 ml) a day.
Slovenian: Odrasli, mladostniki in otroci, ki tehtajo vsaj 25 kg Običajni odmerek zdravila Ziagen je 600 mg (30 ml) na dan. Vzamete ga lahko 300 mg (15 ml)
English: In a meta-analysis of five clinical trials where abacavir was added to intensify therapy, of 166 subjects, 123 (74%) had M184V/I, 50 (30%) had T215Y/F, 45 (27%) had M41L, 30 (18%) had K70R and 25 (15%) had D67N.
Slovenian: V metaanalizi petih kliničnih preskušanj, v katerih je bil abakavir dodan 166 osebam zaradi stopnjevanja zdravljenja, je 123 oseb (74 %) imelo M184V/I, 50 oseb (30 %) T215Y/F, 45 oseb (27 %) M41L, 30 oseb (18 %) K70R in 25 oseb (15 %) D67N.
English: In reproductive toxicity studies, embryo and foetal toxicity have been observed in rats but not in rabbits.
Slovenian: V študijah reproduktivne toksičnosti so opazili embrionalno in fetalno toksičnost pri podganah, ne pa tudi pri kuncih.
English: ABC HSR and expand on the information already included in the currently approved EU SPC:
Slovenian: Ključni elementi, vključeni v izobraževalno gradivo za povečanje razumevanja in ozaveščenosti o preobčutljivostnih reakcijah na ABC in razširitev informacij, ki so že vključene v trenutno odobreni SPC za EU:
English: In this study abacavir increased the mean methadone systemic clearance by 22%.
Slovenian: V tej študiji je abakavir pospešil povprečno izločanje metadona iz organizma za 22%.
English: Ziagen also contains preservatives (parahydroxybenzoates) which may cause allergic reactions (possibly delayed).
Slovenian: Zdravilo Ziagen vsebuje tudi konzervanse (parahidroksibenzoate), ki lahko povzročijo alergijske reakcije (možne so zapoznele reakcije).
English: -4.8% (95% CI -11.5% to +1.9%), p=0.16
Slovenian: -4,8 % (95 % IZ od -11,5 % do +1,9 %), p = 0,16
English: You should immediately contact your doctor if you think you are having a hypersensitivity reaction to Ziagen.
Slovenian: Nemudoma pokličite svojega zdravnika, če mislite, da imate preobčutljivostno reakcijo na zdravilo
English: For general Ziagen information enquiries, contact ……………….Tel …………… (local company name and telephone number will be inserted here).
Slovenian: Za vsa splošna vprašanja o zdravilu Ziagen pokličite ..….Tel ….. (vnešeno bo ime in telefonska številka lokalnega predstavništva)
English: The remainder is eliminated in the faeces.
Slovenian: Ostanek se izloči z blatom.
English: -2.3% (95% CI -9.3% to +4.7%), p=0.52
Slovenian: -2,3 % (95 % IZ od -9,3 % do +4,7 %), p = 0,52
English: The metabolites and unchanged abacavir account for about 83% of the administered abacavir dose in the urine.
Slovenian: Delež presnovkov in nespremenjenega abakavirja, ki se izločijo v seču, znaša približno 83 % prejetega odmerka.
English: -1.6% (95% CI -8.4% to +5.2%), p=0.65
Slovenian: -1,6 % (95 % IZ od -8,4 % do +5,2 %), p = 0,65
English: If you forget to take Ziagen
Slovenian: Če ste pozabili vzeti zdravilo Ziagen
English: Regardless of HLA-B*5701 status, patients who are diagnosed with a hypersensitivity reaction must discontinue abacavir immediately.
Slovenian: Ne glede na status HLA-B*5701 morajo bolniki, pri katerih je ugotovljena preobčutljivostna reakcija, nemudoma prenehati z jemanjem abakavirja.
English: Write your doctor's details below:
Slovenian: Spodaj napišite podatke o svojem zdravniku.
English: The scored tablets are yellow, biconvex, capsule shaped and are engraved with ‘GX 623' on both sides.
Slovenian: Rumene bikonveksne tablete v obliki kapsule z razdelilno zarezo in oznako 'GX 623' na obeh straneh.
English: What Ziagen looks like and contents of the pack
Slovenian: Izgled zdravila Ziagen in vsebina pakiranja
English: Remember to tell your doctor or pharmacist if you begin taking a new medicine while you are taking Ziagen.
Slovenian: Zdravniku ali farmacevtu morate vedno povedati, če med zdravljenjem z zdravilom Ziagen začnete prejemati kakšno novo zdravilo.
English: The pack also includes a polyethylene syringe-adapter and a 10 ml oral dosing syringe comprised of a polypropylene barrel (with ml graduations) and a polyethylene plunger.
Slovenian: V škatli je priložen tudi nastavek za brizgo in 10 ml odmerno breizgo, ki je setavljena iz polipropilenske cevi (z ml lestvico) in polietilenskega bata.
English: Contact your doctor immediately:
Slovenian: Nemudoma se posvetujte z zdravnikom:
English: In vivo resistance (Therapy experienced patients)
Slovenian: Odpornost in vivo (bolniki, ki so že bili zdravljeni)
English: The results showed that there was a mean (90%CI) increase of 1.89 fold [1.32; 2.70] in the abacavir AUC, and 1.58 [1.22; 2.04] fold in the elimination half-life.
Slovenian: Rezultati so pokazali, da se je AUC abakavirja povprečno povečala za 1,89-krat (1,32; 2,70); 90 % interval zaupanja, eliminacijska razpolovna doba pa povprečno za 1,58-krat (1,22; 2,04); 90 % interval zaupanja.
English: • feeling sick (nausea)
Slovenian: • slabost (nauzea),
English: Children receiving abacavir oral solution according to the recommended dosage regimen achieve plasma abacavir exposure similar to adults.
Slovenian: Otroci, ki prejemajo abakavir v obliki peroralne raztopine po priporočenem režimu odmerjanja, dosežejo podobno izpostavljenost abakavirju v plazmi kot odrasli.
English: Ziagen can be taken with or without food.
Slovenian: Ziagen lahko vzamete s hrano ali brez.
English: Children from one year of age weighing less than 25 kg
Slovenian: Otroci, od enega leta starosti, ki tehtajo manj kot 25 kg
English: If you have stopped taking Ziagen
Slovenian: Če ste prenehali jemati zdravilo Ziagen
English: Important information about some of the other ingredients of Ziagen oral solution
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Ziagen peroralne raztopine
English: The pharmacokinetics of abacavir has not been studied in patients over 65 years of age.
Slovenian: Pri bolnikih, starejših od 65 let, niso izvajali farmakokinetičnih študij z abakavirjem.
English: Herts SG12 0DJ
Slovenian: Hertfordshire SG12 0DJ Velika Britanija ali
English: Children from 3 months of age weighing less than 25 kg
Slovenian: Otroci, od treh mesecev starosti, ki tehtajo manj kot 25 kg
English: After a 600 mg abacavir tablet dose, the mean (CV) abacavir Cmax was approximately 4.26 µg/ml (28%) and the mean (CV) AUC∞ was 11.95 µg.h/ml (21%).
Slovenian: Po 600 mg odmerku abakavirja v obliki tablet je bila srednja (CV) Cmax abakavirja približno 4,26 µg/ml (28 %), srednja (CV) AUC∞ pa 11,95 µg.h/ml
English: The induction of drug metabolising enzymes cannot therefore be excluded.
Slovenian: Zato ne moremo izključiti indukcije encimov, ki presnavljajo zdravilo.
English: Summary of Stead-State Plasma Abacavir AUC (0-24) (µg.h/ml) and Statistical Comparisons for Once and Twice-Daily Oral Administration Across Studies
Slovenian: Povzetek AUC (0-24) abakavirja v plazmi v stanju dinamičnega ravnovesja (µg.h/ml) in statistične primerjave peroralne uporabe enkrat in dvakrat na dan v študijah Študija
English: In PENTA 15 study, the geometric mean plasma abacavir AUC(0-24) (95% CI) of the four subjects under 12 months of age who switch from a twice daily to a once daily regimen (see section 5.1) are 15.9 (8.86, 28.5) µg.h/ml in the once-daily dosing and 12.7 (6.52, 24.6) µg.h/ml in the twice-daily dosing.
Slovenian: V študiji PENTA 15 je bila geometrična srednja vrednost AUC (0-24) (95 % IZ) abakavirja v plazmi pri štirih preiskovancih, mlajših od 12 mesecev, ki so prešli z režima odmerjanja dvakrat na dan na režim odmerjanja enkrat na dan (glejte poglavje 5.1) 15,9 (8,86; 28,5) µg.h/ml med odmerjanjem enkrat na dan ter 12,7 (6,52; 24,6) µg.h/ml med odmerjanjem dvakrat na dan.
English: Contains amongst others: sorbitol (340 mg/ml, E420), methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216).
Slovenian: Med drugim vsebuje tudi: sorbitol (340 mg/ml, E420), metilparahidroksibenzoat (E218) in propilparahidroksibenzoat (E216).
English: The demonstration of the benefit of Ziagen is mainly based on results of studies performed with a twice daily regimen, in treatment-naïve adult patients on combination therapy (see section 5.1).
Slovenian: Prikaz prednosti zdravila Ziagen v glavnem temelji na rezultatih študij, ki so bile pri režimu odmerjanja dvakrat na dan izvedene pri odraslih bolnikih, ki še niso bili zdravljeni s kombinirano terapijo (glejte poglavje 5.1).
English: • After stopping treatment with Ziagen for reasons of a suspected HSR, Ziagen or any other medicinal product containing abacavir (e.g. Kivexa, Trizivir, Triumeq) must never be reinitiated.
Slovenian: • Po prenehanju zdravljenja z zdravilom Ziagen iz razloga suma na HSR, se zdravila Ziagen ali katerega koli drugega zdravila, ki vsebuje abakavir ( npr. Kivexa, Trizivir, Triumeq) nikoli ne sme ponovno uvesti.
English: If you accidentally take too much Ziagen, tell your doctor or your pharmacist, or contact your nearest hospital emergency department for further advice.
Slovenian: Če ste vzeli večji odmerek zdravila Ziagen, kot bi smeli Če ste po nesreči vzeli preveč zdravila Ziagen, se nemudoma posvetujte z zdravnikom ali s farmacevtom ali se za dodatne nasvete obrnite na oddelek nujne pomoči najbližje bolnišnice.
English: A 10 ml oral dosing syringe and a plastic adapter for the bottle are included in the pack.
Slovenian: Priložena je tudi 10 ml peroralna odmerna brizga in plastični nastavek za steklenico.
English: In pre-clinical toxicology studies, abacavir treatment was shown to increase liver weights in rats and monkeys.
Slovenian: Predklinične toksikološke študije so pokazale, da je zdravljenje z abakavirjem povečalo težo jeter pri podganah in opicah.
English: Pharmacokinetic data were derived from 3 pharmacokinetic studies (PENTA 13, PENTA 15 and ARROW PK substudy) enrolling children under 12 years of age.
Slovenian: Farmakokinetični podatki so bili pridobljeni iz 3 farmakokinetičnih študij (PENTA 13, PENTA 15 in
English: Abacavir has no effect on the metabolism of ethanol.
Slovenian: Abakavir ne vpliva na presnovo etanola.
English: These results indicate that abacavir has a weak potential to cause chromosomal damage both in vitro and in vivo at high test concentrations.
Slovenian: Rezultati kažejo, da ima abakavir pri visokih testnih koncentracijah tako in vitro kot in vivo majhen potencial za povzročitev kromosomske okvare.
English: The majority of these tumours occurred at the highest abacavir dose of 330 mg/kg/day in mice and 600 mg/kg/day in rats.
Slovenian: Večina teh tumorjev se je razvila pri dajanju najvišjih odmerkov, to je 330 mg/kg/dan pri miših in
English: Carefully read all the information about hypersensitivity reactions in Section 4.
Slovenian: Natančno preberite vse informacije o preobčutljivostnih reakcijah v poglavju 4.
English: No conclusion can be drawn with regard to the teratogenic potential of abacavir because of this embryo-foetal toxicity.
Slovenian: Iz teh ugotovitev o embrio fetalni toksičnosti ni bilo mogoče podati zaključkov o teratogenem potencialu abakavirja.
English: None M184V alone 75 -0.74 Any one NRTI
Slovenian: Brez Samo M184V 75 Katerakoli ena mutacija NRTI 82
English: See leaflet for further information.
Slovenian: Za podrobne informacije glejte navodilo za uporabo.
English: Film-coated Tablets
Slovenian: Filmsko obložene tablete
English: Malignant tumours occurred in the preputial gland of males and the clitoral gland of females of both species, and in rats in the thyroid gland of males and the liver, urinary bladder, lymph nodes and the subcutis of females.
Slovenian: Maligni tumorji so se pri samcih obeh vrst pojavljali na prepucialni žlezi, pri samicah obeh vrst pa na klitorisu, medtem, ko so se pri podganjih samcih pojavljali na ščitnici, pri podganjih samicah pa na jetrih, sečnem mehurju, limfnih vozlih in v podkožju.
English: Additionally, autoinduction of abacavir metabolism or induction of the metabolism of other medicinal products hepatically metabolised has not been observed in man.
Slovenian: Prav tako pri človeku še niso preučevali avtoindukcije presnove abakavirja ali indukcije presnove drugih zdravil, ki se presnavljajo v jetrih.
English: It is supplied in cartons containing a white polyethylene bottle, with a child resistant cap.
Slovenian: Pakirana je v škatli, ki vsebuje bel polietilenski vsebnik z za otroke varno zaporko.
English: About 3 to 4 in every 100 patients treated with abacavir in a clinical trial who did not have the HLAB*5701 gene developed a hypersensitivity reaction.
Slovenian: V kliničnem preskušanju se je približno pri 3 do 4 od 100 bolnikov, ki so prejemali abakavir in niso imeli gena HLA-B*5701, pojavila preobčutljivostna reakcija (resna alergijska reakcija).
English: Even patients who don't have the HLA-B*5701 gene may still develop a hypersensitivity reaction (a serious allergic reaction).
Slovenian: Tudi pri bolnikih, ki nimajo gena HLA-B*5701, se lahko pojavi preobčutljivostna reakcija (resna alergijska reakcija).
English: The other ingredients are microcrystalline cellulose, sodium starch glycollate, magnesium stearate and colloidal anhydrous silica in the core of the tablet.
Slovenian: Pomožne snovi so mikrokristalna celuloza, natrijev karboksimetilškrob, magnezijev stearat in brezvodni koloidni silicijev dioksid v jedru tablete.
English: Ziagen oral solution is supplied in high density polyethylene bottles with child-resistant closures, containing 240 ml of oral solution.
Slovenian: Zdravilo Ziagen peroralna raztopina je pakirano v polietilenskih vsebnikih z za otroke varnimi zaporkami, ki vsebujejo 240 ml peroralne raztopine.
English: 60 film-coated, scored tablets
Slovenian: 60 filmsko obloženih tablet z razdelilno zarezo
English: Ziagen contains the active ingredient abacavir.
Slovenian: Zdravilo Ziagen vsebuje zdravilno učinkovino abakavir.
English: Remove the syringe from the adapter Put the syringe into your mouth, placing the tip of the syringe against the inside of your cheek.
Slovenian: Odmerno brizgo vstavite v usta s konico brizge v smeri proti licem.
English: 240 ml oral solution
Slovenian: 240 ml peroralna raztopina
English: According to clinical trials performed in children abacavir is rapidly and well absorbed from oral solution and tablet formulations administered to children.
Slovenian: Klinični poskusi pri otrocih so pokazali, da se abakavir hitro in dobro absorbira iz peroralne raztopine in tablet.
English: Based on limited experience Ziagen should be avoided in patients with end-stage renal disease.
Slovenian: Zaradi omejenih izkušenj naj bolniki v končnem stadiju ledvične odpovedi ne uporabljajo zdravila Ziagen.
English: Don't push too hard and squirt the liquid into the back of your throat, or you may choke Repeat steps 3 to 7 in the same way until you have taken your whole dose.
Slovenian: št. od 3 do 7 ponavljajte na enak način, dokler ne vzamete vašega celotnega odmerka.
English: Ziagen is not recommended in patients with moderate or severe hepatic impairment (see sections 4.2 and 5.2).
Slovenian: Zdravilo Ziagen se ne priporoča pri bolnikih z zmerno ali hudo jetrno okvaro (glejte poglavji 4.2 in 5.2).
English: How to take Ziagen
Slovenian: Kako jemati zdravilo Ziagen
English: In adults treated with abacavir in combination with lamivudine and zidovudine the proportion of patients with undetectable viral load (<400 copies/ml) was approximately 70% (intention to treat analysis at 48 weeks) with corresponding rise in CD4 cells.
Slovenian: Pri odraslih, ki so se zdravili z abakavirjem v kombinaciji z lamivudinom in zidovudinom, je znašal delež bolnikov z virusno obremenitvijo, ki je ni bilo več moč detektirati (< 400 kopij/ml) in z vzporednim zvišanjem števila CD4 celic približno 70 % (analiza vseh bolnikov vključenih v študijo po 48 tednih).
English: In a crossover study in 27 HIV-infected patients, intracellular carbovir-TP exposures were higher for the abacavir 600 mg once daily regimen (AUC24,ss + 32 %, Cmax24,ss + 99 % and Ctrough + 18 %) compared to the 300 mg twice daily regimen.
Slovenian: V navzkrižni študiji pri 27 bolnikih, okuženih z virusom HIV, je bila znotrajcelična izpostavljenost karbovir-TP-ju večja pri režimu odmerjanja abakavirja 600 mg enkrat na dan (AUC24,ss + 32 %, Cmax24,ss + 99 % in Ctrough + 18 %) kot pri režimu odmerjanja 300 mg dvakrat na dan. Ti podatki na splošno podpirajo uporabo abakavirja v odmerku 600 mg enkrat na dan za zdravljenje bolnikov, okuženih z virusom HIV.
English: containing products.
Slovenian: povezanih s HIV.
English: Although a similar antiviral effect was observed between the abacavir and indinavir containing regimens in terms of proportion of patients with undetectable viral load (≤400 copies/ml; intention to treat analysis (ITT), 47% versus 49%; as treated analysis (AT), 86% versus 94% for abacavir and indinavir combinations respectively), results favoured the indinavir combination, particularly in the subset of patients with high viral load (>100,000 copies/ml at baseline; ITT, 46% versus 55%; AT, 84% versus 93% for abacavir and indinavir respectively).
Slovenian: Čeprav je bil protivirusni učinek kombinacije z abakavirjem v primerjavi s kombinacijo z indinavirjem podoben v deležu bolnikov z nezaznavno virusno obremenitvijo (≤ 400 kopij/ml; analiza vseh vključenih bolnikov (ITT - »intention to treat«): 47 % proti 49 %; analiza vseh bolnikov, ki so končali zdravljenje (AT - »as treated«): 86 % proti 94 %, za kombinacijo z abakavirjem oziroma kombinacijo z indinavirjem), so se rezultati nagibali v korist kombinaciji z indinavirjem, še zlasti v podskupini bolnikov z visoko virusno obremenitvijo (> 100.000 kopij/ml v izhodišču; ITT: 46 % proti 55 %; AT: 84 % proti 93 %, za abakavir oziroma indinavir).
English: Single doses up to 1200 mg and daily doses up to 1800 mg of Ziagen have been administered to patients in clinical studies.
Slovenian: V kliničnih študijah so bolniki prejemali posamezne odmerke do 1200 mg in dnevne odmerke do 1800 mg zdravila Ziagen.
English: Proportions with HIV-1 RNA < 50 copies/ml (50% versus 47%) and < 400 copies/ml (54% versus 57%) were also similar in each group (ITT population).
Slovenian: (vsi vključeni bolniki) je bil ugotovljen tudi podoben odstotek HIV-1 RNA < 50 kopij/ml (50 % proti 47 %) in < 400 kopij/ml (54 % proti 57 %).
English: Following oral administration, the mean time (tmax) to maximal serum concentrations of abacavir is about 1.5 hours for the tablet formulation and about 1.0 hour for the solution formulation.
Slovenian: do največje koncentracije abakavirja v serumu približno 1,5 ure za tablete in približno 1 uro za raztopino.
English: Therefore no dosage reduction is required in patients with renal impairment.
Slovenian: Zato za bolnike z ledvično okvaro ni treba prilagajati odmerkov.
English: The abacavir + lamivudine once daily dosing group was demonstrated to be non-inferior to the twice daily group according to the pre-specified non-inferiority margin of -12%, for the primary endpoint of <80 c/mlat Week 48 as well as at Week 96 (secondary endpoint) and all other thresholds tested (<200c/ml, <400c/ml, <1000c/ml), which all fell well within this non-inferiority margin.
Slovenian: Dokazano je bilo, da je skupina z odmerjanjem abakavirja + lamivudina enkrat na dan neinferiorna skupini z odmerjanjem dvakrat na dan glede na vnaprej opredeljeno mejo neinferiornosti -12 % za primarni opazovani dogodek < 80 kopij/ml v 48. tednu in v 96. tednu (sekundarni opazovani dogodek), ter vse druge testirane prage (< 200 kopij/ml, < 400 kopij/ml, < 1000 kopij/ml), ki so bili vsi znotraj omenjene meje neinferiornosti.
English: Abacavir is primarily metabolised by the liver with approximately 2% of the administered dose being renally excreted, as unchanged compound.
Slovenian: Abakavir se v prvi vrsti presnavlja v jetrih, približno 2 % prejetega odmerka pa se izloči skozi ledvice v nespremenjeni obliki.
English: Take special care with Ziagen
Slovenian: Bodite posebno pozorni pri jemanju zdravila Ziagen
English: Due to the high proportion of premature discontinuation (42% of patients discontinued randomised treatment by week 48), no definitive conclusion can be drawn regarding the equivalence between the treatment regimens at week 48.
Slovenian: Zaradi visokega deleža prezgodnjih prekinitev (42 % bolnikov je zdravljenje prekinilo do
English: The adapter is placed in the neck of the bottle and the syringe attached to this.
Slovenian: Nastavek se namesti na vrat stekleničke, nanj pa pritrdi odmerna brizga.
English: These findings should be considered for any child exposed in utero to nucleotide and nucleotide analogues, who presents with severe clinical findings of unknown etiology, particularly neurologic findings.
Slovenian: Te ugotovitve je treba upoštevati pri vseh otrokih, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom,
English: A plastic adapter and oral dosing syringe are provided for accurate measurement of the prescribed dose of oral solution.
Slovenian: Za natančno odmerjanje predpisanega odmerka peroralne raztopine sta priložena plastični nastavek in peroralna odmerna brizga.
English: GlaxoSmithKline Pharmaceuticals S.A., ul., Grunwaldzka 189, 60-322 Poznan, Poland.
Slovenian: Grunwaldzka 189, 60-322 Poznan, Poljska
English: The oral solution is clear to slightly opalescent yellowish, aqueous solution which may turn into a brown colour over time
Slovenian: Peroralna raztopina je bistra do rahlo svetlikajoče rumenkasta vodna raztopina, ki pa lahko čez čas postane rjava.
English: As well as the side effects listed below for Ziagen, other conditions can develop during combination therapy for HIV.
Slovenian: Poleg spodaj naštetih neželenih učinkov zdravila Ziagen se lahko med kombiniranim zdravljenjem okužbe s HIV pojavijo še druge spremembe.
English: ViiV Healthcare BV, Huis ter Heideweg 62, 3705 LZ Zeist, Netherlands
Slovenian: ViiV Healthcare BV, Huis ter Heideweg 62, 3705 LZ Zeist, Nizozemska
English: Children weighing 14 to < 20 kg: The recommended dose is 300 mg daily.
Slovenian: Otroci, ki tehtajo od 14 do 20 kg: Priporočeni odmerek je 300 mg dnevno.
English: Potent enzymatic inducers such as rifampicin, phenobarbital and phenytoin may via their action on UDP-glucuronyltransferases slightly decrease the plasma concentrations of abacavir.
Slovenian: Močni induktorji encimov kot so rifampicin, fenobarbital in fenitoin lahko s svojim delovanjem na