FrancophonIA/ELRC3.0 huggingface dataset:
English: Dacomitinib was tested using a series of genetic toxicology assays.
Danish: Dacomitinib blev testet ved brug af en række genetiske, toksikologiske analyser.
English: Elderly population No starting dose adjustment of Vizimpro in elderly (≥ 65 years of age) patients is required (see section
Danish: Ældre Det er ikke nødvendigt at justere startdosis af Vizimpro hos ældre patienter (alder ≥65 år) (se pkt.
English: • Nausea or vomiting
Danish: • Kvalme eller opkastning
English: Other information on drug-drug interactions
Danish: Anden information vedrørende lægemiddelinteraktioner
English: In vitro studies indicated that CYP2D6 was the major CYP isozyme involved in the formation of O-desmethyl dacomitinib, while CYP3A4 contributed to the formation of other minor oxidative metabolites.
Danish: In vitro-studier tyder på, at CYP2D6 er det vigtigste CYP-isozym, der er involveret i dannelsen af O-desmethyldacomitinib, mens CYP3A4 bidrager til dannelsen af andre mindre vigtige oxidative metabolitter.
English: Do not use this medicine after the expiry date which is stated on the carton and the blister after EXP.
Danish: Brug ikke dette lægemiddel efter den udløbsdato, der står på pakningen og blisteren efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Second dose reduction
Danish: Anden dosisreduktion
English: All Grades
Danish: Alle grader
English: Careful assessment of all patients with an acute onset or unexplained worsening of pulmonary symptoms (e.g., dyspnoea, cough, fever) should be performed to exclude ILD/pneumonitis.
Danish: Der skal foretages en grundig vurdering af alle patienter med akut debut og/eller uforklarlig forværring af lungesymptomer (fx dyspnø, hoste, feber) for at udelukke ILS/pneumonitis.
English: Vizimpro is used to treat adults with a type of lung cancer called ‘non-small cell lung cancer'.
Danish: Vizimpro bruges til behandling af voksne patienter med en type lungekræft, som kaldes ”ikkesmåcellet lungekræft”.
English: What you need to know before you take Vizimpro 3.
Danish: Det skal du vide, før du begynder at tage Vizimpro 3.
English: In non-Asian patients, median PFS was 9.3 months for dacomitinib arm and 9.2 months for gefitinib arm.
Danish: For ikkeasiatiske patienter var den mediane PFS 9,3 måneder for dacomitinib-armen og 9,2 måneder for gefitinib-armen.
English: Effect of Dacomitinib on UGT Enzymes
Danish: Effekt af dacomitinib på UGT-enzymer
English: If ILD/pneumonitis is confirmed, dacomitinib should be permanently discontinued and appropriate treatment instituted as necessary (see section 4.2).
Danish: Hvis ILS/pneumonitis bekræftes, skal dacomitinib seponeres permanent, og en passende behandling skal initieres efter behov (se pkt.
English: United Kingdom Pfizer Limited Tel: +44 (0) 1304 616161
Danish: Storbritannien Pfizer Limited Tel: +44 (0) 1304 616161
English: Patients with brain metastases or leptomeningeal disease or ECOG PS ≥ 2 were excluded from the trial.
Danish: Patienter med hjernemetastaser eller leptomeningeal sygdom eller en ECOG-performancestatus på ≥2 blev ekskluderet fra studiet.
English: Vizimpro may increase exposure (or decrease exposure of active metabolites) of other medicinal products metabolised by CYP2D6.
Danish: Vizimpro kan øge eksponeringen (eller nedsætte eksponeringen for aktive metabolitter) for andre lægemidler, der metaboliseres via CYP2D6.
English: Tell your doctor if a rash starts.
Danish: Fortæl det til lægen, hvis du får begyndende udslæt.
English: In Asian patients, median PFS was 16.5 months for dacomitinib arm and 9.3 months for gefitinib arm.
Danish: For asiatiske patienter var den mediane PFS 16,5 måneder for dacomitinib-armen og 9,3 måneder for gefitinib-armen.
English: Breast-feeding Do not breast-feed while taking this medicine because it is not known if it can harm your baby.
Danish: Du må ikke amme, mens du tager dette lægemiddel, eftersom det ikke vides, om denne medicin kan skade barnet.
English: This metabolite exhibited in vitro pharmacologic activity that was similar to that of dacomitinib in the in vitro biochemical assays.
Danish: Denne metabolit udviste farmakologisk in vitroaktivitet som var sammenlignelig med dacomitinibs i biokemiske in vitro-analyser.
English: Film coating: Opadry II Blue 85F30716 containing polyvinyl alcohol - partially hydrolysed (E1203), talc (E553b), titanium dioxide (E171), macrogol (E1521), Indigo carmine aluminium lake (E132).
Danish: Filmovertræk: Opadry II Blue 85F30716 indeholdende polyvinylalkohol - delvist hydrolyseret (E1203), talcum (E553b), titandioxid (E171), macrogol (E1521), Indigo carmine aluminium lake (E132).
English: From the small number of patients in the moderate group [total bilirubin > 1.5 to 3 × ULN and any AST; N=5], there is no evidence for a change in dacomitinib pharmacokinetics.
Danish: Bedømt ud fra det lille antal patienter i gruppen med moderat nedsat leverfunktion (total bilirubin >1,5 til 3 × ULN og en hvilken som helst ASAT; N=5), er der ingen evidens for en ændring af dacomitinibs farmakokinetik.
English: These results suggest that dacomitinib may increase exposure of other medicinal products (or decrease exposure to active metabolites) primarily metabolised by CYP2D6.
Danish: Disse resultater indikerer, at dacomitinib kan forøge eksponeringen for andre lægemidler (eller nedsætte eksponeringen for aktive metabolitter), der hovedsagelig metaboliseres af CYP2D6.
English: Start oral antibiotics and topical steroids in patients who develop exfoliative skin conditions.
Danish: Start behandling med oral antibiotika og topikale steroider hos patienter, som udvikler eksfoliative hudsygdomme.
English: • Abnormal amount of body hair growth
Danish: • Unormal hårvækst på kroppen
English: In plasma, dacomitinib binds to albumin and 1-acid glycoprotein and the fraction unbound is approximately 2% in vitro and ex vivo in healthy volunteers.
Danish: Dacomitinib bindes til albumin og 1-acid glycoprotein i plasma, og den ubundne fraktion er omtrent 2% in vitro og ex vivo hos frivillige raske forsøgspersoner.
English: Each pack contains 30 film-coated tablets.
Danish: Hver pakning indeholder 30 filmovertrukne tabletter.
English: Women of childbearing potential who are receiving this medicinal product should use adequate contraceptive methods during therapy and for at least 17 days (5 half-lives) after completing therapy.
Danish: Fertile kvinder, som får dette lægemiddel, skal anvende sikker prævention under behandlingen og i mindst 17 dage (5 halveringstider) efter behandlingsophør.
English: The maternally toxic dose was foetotoxic in rats, resulting in reduced foetal body weights and higher incidence of unossified metatarsals.
Danish: Den maternelt toksiske dosis var toksisk for fostre hos rotter, hvilket resulterede i reduceret føtal kropsvægt og højere forekomst af manglende ossifikation af metatarsalerne.
English: Progression-Free Survival (per IRC) Number of patients with event, n (%) Median PFS in months (95% CI) HR (95% CI)
Danish: Progressionsfri overlevelse (ifølge IRC) Antal patienter med hændelser, n (%) Median PFS i måneder (95% CI) HR (95% CI)
English: Abbreviations: CI=confidence interval; HR=hazard ratio; IRC=independent radiologic central; ITT=Intent-To-Treat; N=total number; PFS=progression-free survival.
Danish: Forkortelser: CI=konfidensinterval; HR=hazard-ratio; IRC=den uafhængige radiologiske komité (Independent Radiologic Central); ITT=Intent-To-Treat; N=totalt antal; PFS=progressionsfri overlevelse.
English: Treatment with dacomitinib should be withheld pending investigation of these symptoms.
Danish: Behandling med dacomitinib skal seponeres midlertidigt, indtil resultatet af undersøgelsen af disse symptomer foreligger.
English: Across the dacomitinib program, hepatic failure led to a fatal outcome in 1 patient.
Danish: På tværs af dacomitinibprogrammet førte leversvigt til dødsfald hos 1 patient.
English: • Flushed or painful palms or soles
Danish: • Rødmende eller smertefulde håndflader eller fodsåler
English: Dacomitinib is extensively distributed throughout the body with a mean steady-state volume of distribution of 27 L/kg (patient of 70 kg) [coefficient of variation (CV%): 18%] following intravenous administration.
Danish: Dacomitinib fordeles i hele kroppen med et gennemsnitligt steady state-fordelingsvolumen på 27 l/kg (patient som vejer 70 kg) (variationskoefficient (CV): 18%) efter en intravenøs administration.
English: The adverse reactions observed at doses greater than 45 mg once daily were primarily gastrointestinal, dermatological, and constitutional (e.g., fatigue, malaise, and weight loss).
Danish: Bivirkningerne, der blev observeret ved doser over 45 mg en gang dagligt, var primært gastrointestinale, dermatologiske og almene symptomer (fx træthed, utilpashed og vægttab).
English: In oral repeated-dose toxicity studies for up to 6 months in rats and 9 months in dogs, the primary toxicities were identified in the skin/hair (dermal changes in rats and dogs, atrophy/dysplasia of hair follicles in rats), kidney (papillary necrosis often accompanied by tubular degeneration, regeneration, dilatation and/or atrophy and changes in urinary markers indicative of renal injury in rats, erosion or ulceration of the pelvic epithelium with associated inflammation without changes indicative of renal dysfunction in dogs), eye (cornea epithelial atrophy in rats and dogs, corneal ulcers/erosions with red/swollen conjunctiva(e), conjunctivitis, elevated third eyelid, increased squinting, partially closed eyes, lacrimation, and/or ocular discharge in dogs), and digestive system (enteropathy in rats and dogs, erosions/ulcers of the mouth with reddened mucous membranes in dogs), and atrophy of epithelial cells of other organs in rats.
Danish: I forsøg med rotter af en varighed på op til 6 måneder, og med hunde af en varighed på 9 måneder, der undersøgte toksicitet ved gentagne orale doser, blev der primært fundet toksiciteter i huden/håret (hudforandringer hos rotter og hunde, atrofi/dysplasi i hårfolliklerne hos rotter), nyrerne (papillær nekrose, ofte ledsaget af tubulær degeneration, regenerering, dilatation og/eller atrofi og ændringer i urinmarkører, der indikerer nyreskade hos rotter, erosion eller sårdannelse i bækkenepitelet med tilhørende inflammation uden ændringer, der indikerer renal dysfunktion hos hunde), øjnene (epithelial hornhindeatrofi hos rotter og hunde, sår i hornhinden/erosioner med rød/hævet konjunktiva(e), konjunktivitis, fremfald af tredje øjenlåg, øget skelen, delvist lukkede øjne, lakrimation og/eller udflåd fra øjnene hos hunde) og fordøjelsessystemet (enteropati hos rotter og hunde, erosioner/sår i munden med røde slimhinder hos hunde) og epitelcelleatrofi i andre organer hos rotter.
English: The pharmacokinetics in patients requiring haemodialysis have not been studied.
Danish: Farmakokinetikken hos patienter, som har behov for hæmodialyse, er ikke blevet undersøgt.
English: Pharmacotherapeutic group: Anti-neoplastic agents, protein kinase inhibitors, ATC code: L01XE47
Danish: Farmakoterapeutisk klassifikation: Antineoplastiske stoffer, proteinkinasehæmmere, ATC-kode: L01XE47
English: Studies in animals have shown limited effects on reproductive toxicity (lower maternal body weight gain and food consumption in rats and rabbits, and lower foetal body weight and higher incidence of unossified metatarsals in rats only) (see section 5.3).
Danish: Undersøgelser hos dyr har vist begrænset effekt på reproduktionstoksicitet (lavere maternel forøgelse af kropsvægt og fødeindtagelse hos rotter og kaniner og lavere føtal kropsvægt og højere forekomst af manglende ossifikation i metatarsaler hos rotter) (se pkt.
English: Carcinogenicity studies have not been performed with dacomitinib.
Danish: Der er ikke udført carcinogenicitetsstudier med dacomitinib.
English: No clear relationship between dacomitinib exposure and efficacy could be characterised over the exposure range studied.
Danish: Der sås ingen klar sammenhæng mellem eksponering for dacomitinib og virkning ud fra det undersøgte eksponeringsinterval.
English: This medicinal product contains < 1 mmol sodium (23 mg) per tablet, that is to say essentially “sodium-free”.
Danish: Dette lægemiddel indeholder < 1 mmol natrium (23 mg) pr. tablet, dvs. det er i det væsentlige ”natriumfrit”.
English: Treat with anti-diarrhoeal medicinal products (e.g., loperamide), and adequate oral fluid intake or intravenous fluids or electrolytes as appropriate.
Danish: Behandl med anti-diarré lægemidler (fx loperamid) og tilstrækkelig oral væskeindtagelse eller intravenøs væske eller elektrolytter, efter behov.
English: Patients experiencing fatigue or ocular adverse reactions while taking dacomitinib should exercise caution when driving or operating machinery.
Danish: Patienter, som oplever træthed eller okulære bivirkninger, mens de får dacomitinib, skal udvise forsigtighed, mens de fører motorkøretøj eller betjener maskiner.
English: Marketing Authorisation Holder Pfizer Europe MA EEIG Boulevard de la Plaine 17
Danish: Indehaver af markedsføringstilladelsen Pfizer Europe MA EEIG Boulevard de la Plaine 17
English: Non-clinical safety studies showed reversible epithelial atrophy in the cervix and vagina of rats (see section 5.3).
Danish: Ikke-kliniske sikkerhedsstudier viste reversibel epitelial atrofi i cervix og vagina hos rotter (se pkt.
English: No clinical studies have been conducted in patients with impaired renal function.
Danish: Der er ikke udført kliniske studier hos patienter med nedsat nyrefunktion.
English: Diarrhoea was the most frequently reported adverse reaction in patients receiving Vizimpro (88.6%) and Grade ≥ 3 diarrhoea adverse reactions were reported in 9.4% of patients.
Danish: Diarré var den hyppigst rapporterede bivirkning hos patienter, der fik Vizimpro (88,6%), og bivirkninger i form af diarré af grad ≥3 blev rapporteret hos 9,4% af patienterne.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER STRIPS
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP
English: Vizimpro, as monotherapy, is indicated for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR)-activating mutations.
Danish: Vizimpro, som monoterapi, er indiceret til førstelinjebehandling af voksne patienter med lokalt fremskreden eller metastatisk ikke-småcellet lungecancer (NSCLC) med epidermal vækstfaktorreceptor (EGFR)-aktiverende mutationer.
English: Dacomitinib is a pan-human epidermal growth factor receptor (HER) (EGFR/HER1, HER2, and HER4) inhibitor, with activity against mutated EGFR with deletions in exon 19 or the L858R substitution in exon 21.
Danish: Dacomitinib er en hæmmer af den panhumane epidermale vækstfaktorreceptor (HER) (EGFR/HER1, HER2, og HER4), med aktiviteten rettet mod EGFR der har deletionsmutationer i exon 19 eller L858R-substitutionen i exon 21.
English: In embryo-foetal development studies in rats and rabbits, pregnant animals received oral doses up to approximately 2.4 times and 0.3 times, respectively, the unbound AUC at the recommended human dose during the period of organogenesis.
Danish: I embryo-føtale udviklingsstudier hos rotter og kaniner fik drægtige dyr orale doser på henholdsvis ca. 2,4 gange og 0,3 gange det ubundne AUC ved den anbefalede humane dosis i perioden med organogenese.
English: • Cracks in the skin
Danish: • Revner i huden
English: Abbreviations: CI=confidence interval; EGFR=epidermal growth factor receptor; HR=hazard ratio; IRC=independent radiologic central; ITT=Intent-to-treat; IWRS=interactive web response system; N/n=total number; NSCLC=non-small cell lung cancer; PFS=progression-free survival; DoR=Duration of Response.
Danish: Forkortelser: CI=konfidensinterval; EGFR=epidermal vækstfaktorreceptor; HR=hazard-ratio; IRC=independent radiologic central; ITT= Intent-to-treat; IWRS= interactive web response-system; N/n=totalt antal; NSCLC=ikke-småcellet lungecancer; PFS=progressionsfri overlevelse; DoR=responsvarighed.
English: • Permanently discontinue dacomitinib if ILD/Pneumonitis is confirmed.
Danish: • Dacomitinib skal seponeres permanent, hvis ILS/pneumonitis bekræftes.
English: Patients should maintain adequate oral hydration and patients who become dehydrated may require administration of intravenous fluids and electrolytes (see section 4.2).
Danish: Patienterne bør sørge for at indtage rigeligt med væske og de patienter, som bliver dehydrerede, kan have behov for indgift af intravenøs væske og elektrolytter (se pkt.
English: Diarrhoea, including severe diarrhoea, has been very commonly reported during treatment with Vizimpro (see section 4.8).
Danish: Diarré, herunder svær diarré, er rapporteret hyppigt under behandling med Vizimpro (se pkt.
English: In 6 healthy male subjects given a single-oral dose of [
Danish: Hos 6 raske mandlige forsøgspersoner, som fik en enkelt oral dosis radioaktivt mærket [
English: Weight decreased a Only adverse reactions with ≥ 10% incidence in the dacomitinib arm are included.
Danish: Der er kun inkluderet bivirkninger med en incidens på ≥10% i dacomitinib-armen.
English: Fertility studies have not been performed with dacomitinib.
Danish: Der er ikke udført fertilitetsstudier med dacomitinib.
English: Dacomitinib is not directly reactive toward DNA as evidenced by the negative response in the bacterial reverse mutation assay and did not induce chromosome damage in a bone marrow micronucleus assay at concentrations up to approximately 60-70 times the unbound AUC or Cmax at the recommended human dose.
Danish: Dacomitinib reagerer ikke direkte med DNA, som påvist ved negativt respons i Ames test, og det inducerede ikke kromosomale skader i en mikronukleustest i knoglemarv ved koncentrationer på op til 60-70 gange det ubundne AUC eller Cmax ved den anbefalede humane dosis.
English: Data from a study in 24 healthy subjects indicated that co-administration of a single 45 mg dacomitinib dose with the PPI rabeprazole 40 mg once daily for 7 days decreased dacomitinib Cmax, AUC0-96h (area under the concentration-time curve from time 0 to 96 hours), and AUCinf (AUC from time 0 to infinity) (n=14) by approximately 51%, 39%, and 29%, respectively, when compared to a single 45 mg dose of dacomitinib administered alone.
Danish: Data fra et studie med 24 raske forsøgspersoner indikerede, at co-administration af en enkelt dosis dacomitinib på 45 mg med PPI'en rabeprazol 40 mg en gang dagligt i 7 dage reducerede dacomitinibs Cmax, AUC0-96t (areal under koncentrations-tidskurven fra tiden 0 til 96 timer) og AUCinf (AUC fra tiden 0 til uendeligt) (n=14) med henholdsvis ca. 51%, 39% og 29% sammenlignet med en enkeltdosis dacomitinib på 45 mg administreret alene.
English: 2-sided p-value b
Danish: 2-sidet p-værdi
English: • Eyes inflammation
Danish: • Øjenbetændelse
English: The most common (> 20%) adverse reactions in patients receiving dacomitinib were diarrhoea (88.6%), rash (79.2%), stomatitis (71.8%), nail disorder (65.5%), dry skin (33.3%), decreased appetite (31.8%), conjunctivitis (24.7%), weight decreased (24.3%), alopecia (23.1%), pruritus (22.4%), transaminases increased (22.0%), and nausea (20.4%).
Danish: De hyppigste (>20%) bivirkninger hos patienter, der fik dacomitinib, var diarré (88,6%), udslæt (79,2%), stomatitis (71,8%), neglesygdom (65,5%), hudtørhed (33,3%), nedsat appetit (31,8%), konjunktivitis (24,7%), vægttab (24,3%), alopeci (23,1%), pruritus (22,4%), forhøjede transaminaser (22,0%) og kvalme (20,4%).
English: Data based on pool of 255 patients who received Vizimpro 45 mg once daily as starting dose for first-line treatment of NSCLC with EGFR-activating mutations across clinical studies.
Danish: Data er baseret på ialt 255 patienter (på tværs af de kliniske studier), der fik Vizimpro 45 mg én gang dagligt som startdosis ved førstelinjebehandling af NSCLC med EGFR-aktiverende mutationer.
English: This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially “sodium-free”.
Danish: Dette lægemiddel indeholder mindre end 1 mmol natrium (23 mg) pr. tablet, dvs. det er i det væsentlige natriumfrit.
English: If you forget to take Vizimpro
Danish: Hvis du har glemt at tage Vizimpro
English: Treatment in this population is not recommended (see section 5.2).
Danish: Behandling hos denne population frarådes (se pkt.
English: Thirty percent had baseline Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 and 70% had ECOG PS 1; 59% had an exon 19 deletion, and 41% had a L858R mutation in exon 21.
Danish: Tredive procent havde en ECOG-performancestatus på 0, og 70% havde en ECOG-performancestatus på 1; 59% havde en deletion i exon 19, og 41% havde en L858R-mutation i exon 21.
English: • Abnormal liver enzyme blood tests
Danish: • Unormale blodtests af leverenzymer
English: • Alteration in taste
Danish: • Smagsforstyrrelser
English: If you stop taking Vizimpro
Danish: Hvis du holder op med at tage Vizimpro
English: It is important to treat the rash early.
Danish: Det er vigtigt, at udslættet behandles tidligt.
English: Initiate treatment with anti-diarrhoeal medicinal products (e.g., loperamide) at first onset of diarrhoea.
Danish: Start behandling med anti-diarré lægemidler (fx loperamid) første gang diarré optræder.
English: Danmark Pfizer ApS Tlf: +45 44 20 11 00
Danish: Pfizer ApS Tlf: +45 44 20 11 00
English: Dacomitinib has the potential to be a very persistent, bioaccumulative and toxic substance (see section 5.3).
Danish: Dacomitinib er et potentielt persistent, bioakkumulerende og toksisk stof (se pkt.
English: Co-administration of single 45 mg oral dose of dacomitinib increased the mean exposure (AUClast and Cmax) of dextromethorphan, a probe CYP2D6 substrate, 855% and 874%, respectively, compared with administration of dextromethorphan alone.
Danish: Co-administration af en enkel oral dosis dacomitinib på 45 mg forøgede den gennemsnitlige eksponering (AUClast og Cmax) for dextromethorphan, et CYP2D6-probesubstrat, med henholdsvis 855% og 874%, sammenlignet med administration af dextromethorphan alene.
English: • Procainamide, used to treat heart arrhythmias
Danish: • Procainamid, som anvendes til at behandle uregelmæssig hjerterytme
English: Patients may require dosing interruption and/or dose reduction of therapy with dacomitinib.
Danish: Det kan være nødvendigt at afbryde og/eller nedsætte patienternes dosis af dacomitinib.
English: Serious adverse reactions were reported in 6.7% of patients treated with dacomitinib.
Danish: Alvorlige bivirkninger blev rapporteret hos 6,7% af de patienter, der blev behandlet med dacomitinib.
English: There is no known antidote for dacomitinib.
Danish: Der er ingen specifik antidot mod dacomitinib.
English: Adverse reactions reported in dacomitinib clinical studies (N=255) System organ class
Danish: Bivirkninger, der er rapporteret fra kliniske studier med dacomitinib (N=255)
English: If you take more Vizimpro than you should If you have taken too much Vizimpro, see a doctor or go to a hospital immediately.
Danish: Hvis du har taget for mange Vizimpro tabletter, skal du straks kontakte en læge eller tage på hospitalet.
English: ILD/pneumonitis adverse reactions were reported in 2.7% of patients receiving Vizimpro, and Grade ≥ 3 ILD/pneumonitis adverse reactions were reported in 0.8%, including a fatal event (0.4%) (see section 4.4).
Danish: Bivirkninger i form af ILS/pneumonitis blev rapporteret hos 2,7% af patienterne, der fik Vizimpro, og grad ≥ 3 bivirkninger i form af ILS/pneumonitis blev rapporteret hos 0,8%, inklusive et tilfælde med dødeligt udfald (0,4%) (se pkt.
English: In vitro, dacomitinib has a low potential to inhibit uridine-diphosphate glucuronosyltransferase (UGT)1A4, UGT1A6, UGT1A9, UGT2B7, and UGT2B15.
Danish: In vitro har dacomitinib lavt potentiale for hæmning uridin-difosfat glucuronosyltransferase (UGT)1A4, UGT1A6, UGT1A9, UGT2B7 og UGT2B15.