FrancophonIA/ELRC3.0 huggingface dataset:
English: The virustatic activity of ganciclovir is a result of the inhibition of viral DNA synthesis by: (1) competitive inhibition of incorporation of deoxyguanosine triphosphate into DNA by DNA polymerase, and (2) incorporation of ganciclovir triphosphate into viral DNA, causing termination of, or very limited, viral DNA elongation.
Croatian: Virustatsko djelovanje ganciklovira posljedica je inhibicije sinteze virusne DNK putem: (1) kompetitivne inhibicije inkorporiranja deoksigvanozin trifosfata u DNK uz pomoć DNK polimeraze i (2) inkorporiranja ganciklovir trifosfata u virusnu DNK, što zaustavlja ili znatno ograničava daljnje produljivanje virusne
English: The volume of distribution of intravenously administered ganciclovir is correlated to body weight.
Croatian: Distribucija Volumen distribucije ganciklovira primijenjenog intravenski u korelaciji je s tjelesnom težinom.
English: • what you are using the medicine for.
Croatian: • tome zbog čega se liječite.
English: All children received intravenous ganciclovir 5 mg/kg twice daily for 2 weeks following transplantation.
Croatian: Sva su djeca primala intravenski ganciklovir u dozi od 5 mg/kg dvaput na dan tijekom 2 tjedna nakon presađivanja.
English: Excipient(s) with known effect: approximately 43 mg (2 mEq) sodium.
Croatian: Pomoćna tvar s poznatim učinkom: približno 43 mg (2 mEq) natrija.
English: Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of herpes viruses both in vitro and in vivo.
Croatian: Ganciklovir je sintetski analog 2'-deoksigvanozina koji inhibira replikaciju virusa herpesa in vitro i in vivo.
English: Only limited data are available in neonates or infants with HIV/AIDS or symptomatic congenital CMV infection treated with valganciclovir or ganciclovir, however the safety profile appears to be consistent with the known safety profile of valganciclovir/ganciclovir.
Croatian: Dostupni su samo ograničeni podaci o novorođenčadi i dojenčadi s HIV-om/AIDS-om ili simptomatskom kongenitalnom CMV infekcijom liječenih valganciklovirom ili ganciklovirom, no čini se da je sigurnosni profil u skladu s poznatim sigurnosnim profilom valganciklovira/ganciklovira.
English: Estimates of ganciclovir clearance for continuous dialysis were lower (4.0−29.6 mL/min) but resulted in greater removal of ganciclovir over a dose interval.
Croatian: Procijenjen klirens ganciklovira tijekom kontinuirane dijalize bio je niži (4,0 do 29,6 ml/min), ali je rezultirao većim uklanjanjem ganciklovira u doznom intervalu.
English: Asymptomatic CMV infection was detected by PCR in 34.4% of subjects and was more likely in high-risk than in routine-risk recipients (58.1% vs. 21.8%, p = 0.0001).
Croatian: Asimptomatska CMV infekcija otkrivena je PCR-om u 34,4% ispitanika i bila je vjerojatnija u visokorizičnih primatelja nego u onih s rutinskim rizikom (58,1% naspram 21,8%,
English: What Cymevene looks like and contents of the pack Cymevene is a white to off white powder for concentrate for solution for infusion, supplied in a singledose glass vial, with a rubber stopper and aluminium closure with flip-off cap.
Croatian: Kako Cymevene izgleda i sadržaj pakiranja Cymevene je bijeli do bjelkasti prašak za koncentrat za otopinu za infuziju koji dolazi u jednodoznoj staklenoj bočici s gumenim čepom i aluminijskim zatvaračem sa zaštitnom kapicom.
English: Based on patient weight the appropriate volume should be removed with a syringe from the vial and further diluted into an appropriate infusion solution.
Croatian: Na temelju tjelesne težine bolesnika potrebno je štrcaljkom izvući odgovarajući volumen lijeka iz bočice i dodatno ga razrijediti u odgovarajućoj infuzijskoj otopini.
English: Draw 10 mL of water for injection into a syringe, then slowly inject through the centre of the rubber stopper into the vial pointing the needle towards the wall of the vial.
Croatian: Izvucite 10 ml vode za injekcije u štrcaljku te je polako ubrizgajte kroz sredinu gumenog čepa u bočicu, usmjeravajući iglu prema stijenci bočice.
English: Therefore, ganciclovir should not be used in pregnant women unless the clinical need for treatment of the woman outweighs the potential teratogenic risk to the foetus.
Croatian: Stoga se ganciklovir ne smije primjenjivati trudnicama, osim ako klinička potreba za liječenjem žene ne nadmašuje moguće teratogene rizike za plod.
English: The diluted solution should then be infused intravenously over 1 hour as directed in section 4.2.
Croatian: Razrijeđenu otopinu tada treba primijeniti intravenskom infuzijom u trajanju od jednog sata, sukladno uputama navedenima u dijelu 4.2.
English: Other medicines and Cymevene Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: • vincristine, vinblastine, doxorubicin - used for cancer,
Croatian: • vinkristin, vinblastin, doksorubicin - koriste se u liječenju raka
English: Abdominal distention Mouth ulceration Pancreatitis
Croatian: distenzija abdomena ulceracije u ustima pankreatitis
English: The steady state volume of distribution has a range of 0.54−0.87 L/kg.
Croatian: Volumen distribucije u stanju dinamičke ravnoteže kreće se u rasponu od 0,54 - 0,87 l/kg.
English: Look out for these while you are taking Cymevene - your doctor may tell you to stop taking Cymevene and you may need urgent medical treatment:
Croatian: Obratite pozornost na njih dok primate Cymevene - liječnik će Vam možda reći da prestanete primjenjivati Cymevene, a možda će Vam biti potrebno hitno liječenje:
English: Patients with renal impairment have an increased elimination half-life and, depending on renal function, it ranges from about 6 to 17 hours (see section 4.2 for dose modifications required in patients with renal impairment).
Croatian: U bolesnika s oštećenom bubrežnom funkcijom produljen je poluvijek eliminacije, koji ovisno o bubrežnoj funkciji iznosi od približno 6 do 17 sati (vidjeti dio 4.2 za prilagodbe doze potrebne u bolesnika s oštećenjem bubrežne funkcije).
English: During the first 14 days of administration it is recommended that white blood cell count (preferably as a differential test) is conducted every second day; in patients with low baseline neutrophil levels (< 1000 neutrophils/µl), those who developed leucopenia during previous therapy with other myelotoxic substances, and those with renal impairment, this monitoring should be performed daily.
Croatian: Tijekom prvih 14 dana primjene preporučuje se kontrolirati broj leukocita (po mogućnosti diferencijalnim leukogramom) svaki drugi dan; u bolesnika s niskim početnim brojem neutrofila (< 1000 stanica/µl), bolesnika u kojih se razvila leukopenija tijekom prethodnog liječenja drugim mijelotoksičnim tvarima i onih s oštećenom bubrežnom funkcijom, te je kontrole potrebno provoditi svakodnevno.
English: Cymevene is used to treat diseases caused by a virus called cytomegalovirus (CMV) in patients who have a weak immune system.
Croatian: Za što se koristi Cymevene Cymevene se koristi za liječenje bolesti uzrokovanih virusom koji se zove citomegalovirus (CMV) u bolesnika sa oslabljenim imunosnim sustavom.
English: It is unknown if ganciclovir is excreted in human breast milk, but the possibility of ganciclovir being excreted in breast milk and causing serious adverse reactions in the breastfed infant cannot be excluded.
Croatian: Nije poznato izlučuje li se ganciklovir u majčino mlijeko, ali se ne može isključiti mogućnost da se izlučuje i uzrokuje ozbiljne nuspojave za dojenče.
English: • you are allergic to aciclovir, valaciclovir, penciclovir or famciclovir - these are other medicines used for viral infections
Croatian: • ako ste alergični na aciklovir, valaciklovir, penciklovir ili famciklovir - to su drugi lijekovi koji se koriste za liječenje virusnih infekcija
English: Therefore, patients taking probenecid and Cymevene should be closely monitored for ganciclovir toxicity.
Croatian: Stoga bolesnike koji uzimaju probenecid i Cymevene treba pomno nadzirati zbog moguće toksičnosti ganciklovira.
English: • abnormal thoughts or feelings, losing contact with reality
Croatian: • neuobičajene misli ili osjećaji, gubitak kontakta sa stvarnošću • krv u mokraći
English: Prevention of CMV disease in adults and adolescents from 12 years of age with normal renal function using prophylaxis or pre-emptive therapy
Croatian: Prevencija CMV bolesti u odraslih i adolescenata od navršenih 12 godina s normalnom bubrežnom funkcijom uz primjenu profilakse ili preemptivne terapije
English: Children treated before 2004 then received oral ganciclovir 30 mg/kg/dose up to 1 g/dose three times daily (n = 41), while children treated after 2004 received valganciclovir up to 900 mg once daily (n = 51).
Croatian: Djeca liječena prije 2004. godine primala su peroralni ganciklovir od 30 mg/kg po dozi do najviše 1 g po dozi triput na dan (n = 41), dok su djeca liječena nakon 2004. godine primala valganciklovir u dozi do najviše 900 mg jedanput na dan (n = 51).
English: Also do this for at least 90 days after Cymevene has been stopped.
Croatian: Koristite je i najmanje 90 dana nakon prestanka primjene lijeka Cymevene.
English: In animals studies ganciclovir was associated with reproductive toxicity and teratogenicity (see sections 4.4 and 5.3).
Croatian: U ispitivanjima na životinjama ganciklovir je bio povezan s reproduktivnom toksičnošću i teratogenošću (vidjeti dijelove 4.4 i 5.3).
English: Hepatic function abnormal Blood alkaline phosphatase increased Aspartate aminotransferase increased
Croatian: poremećaj funkcije jetre povišena razina alkalne fosfataze u krvi povišena razina aspartat aminotransferaze
English: Didanosine plasma concentrations were found to be consistently raised when given with ganciclovir.
Croatian: Utvrđeno je da su koncentracije didanozina u plazmi stalno povećane kada se didanozin primjenjuje s ganciklovirom.
English: Viruses containing mutations in the UL97 gene are resistant to ganciclovir alone, whereas viruses with mutations in the UL54 gene are resistant to ganciclovir but may show cross-resistance to other antivirals that also target viral polymerase.
Croatian: Virusi s mutacijom gena UL97 rezistentni su samo na ganciklovir, dok su virusi s mutacijom gena UL54 rezistentni na ganciklovir, ali mogu pokazivati križnu rezistenciju na druge antivirotike koji također ciljno djeluju na virusnu polimerazu.
English: Such an effect is also anticipated during concomitant administration of intravenous ganciclovir and probenecid.
Croatian: Takav se učinak očekuje i kod istodobne primjene intravenskog oblika ganciklovira s probenecidom.
English: Sodium hydroxide (for pH-adjustment) Hydrochloric acid (for pH-adjustment)
Croatian: 6.1 Popis pomoćnih tvari natrijev hidroksid (za podešavanje pH) kloridna kiselina (za podešavanje pH)
English: • your weight
Croatian: • Vašoj tjelesnoj težini
English: Mean Ganciclovir Plasma half-life (hours)
Croatian: Srednji poluvijek ganciklovira u plazmi (sati)
English: Haemodialysis reduces plasma concentrations of ganciclovir by about 50% after intravenous administration during a 4-hour haemodialysis session.
Croatian: Hemodijaliza smanjuje koncentracije ganciklovira u plazmi za oko 50% nakon intravenske primjene tijekom 4-satne hemodijalize.
English: • changes in blood cell counts
Croatian: • promjene broja krvnih stanica
English: The pharmacokinetics of intravenous ganciclovir were investigated in neonates aged 2−49 days following doses of 4 mg/kg (N = 14) and 6 mg/kg (N = 13).
Croatian: Farmakokinetika intravenski primijenjenog ganciklovira ispitana je u novorođenčadi stare 2 do 49 dana nakon primjene doza od 4 mg/kg (N = 14) i 6 mg/kg (N = 13).
English: Severe thrombocytopenia may be associated with potentially life-threatening bleeding.
Croatian: Teška trombocitopenija može biti povezana s krvarenjem koje može biti opasno po život.
English: The pharmacokinetics of intravenous ganciclovir in infants and children were consistent with those observed in neonates and adults.
Croatian: Farmakokinetika intravenski primijenjenog ganciklovira u dojenčadi i djece u skladu je s onom primijećenom u novorođenčadi i odraslih.
English: However, ganciclovir readily diffuses across the human placenta.
Croatian: Međutim, ganciklovir lako prolazi kroz ljudsku posteljicu.
English: prevention of CMV disease in patients with drug-induced immunosuppression (for example following organ transplantation or cancer chemotherapy).
Croatian: prevenciju CMV bolesti u bolesnika koji pate od imunosupresije izazvane lijekovima (primjerice nakon presađivanja organa ili protutumorske kemoterapije).
English: Thrombocytopenia Leucopenia Pancytopenia
Croatian: trombocitopenija leukopenija pancitopenija
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: {DD month YYYY} Date of latest renewal: {DD month YYYY}
Croatian: Datum posljednje obnove odobrenja: {DD mjesec GGGG}
English: • low blood pressure, which may make you feel dizzy or faint
Croatian: • nizak krvni tlak, što može uzrokovati omaglicu ili nesvjesticu
English: • low red blood cell counts shown in tests
Croatian: • nizak broj crvenih krvnih stanica otkriven u nalazima pretraga
English: Dose modifications for patients with renal impairment:
Croatian: Prilagodbe doze za bolesnike s oštećenjem bubrežne funkcije:
English: Therefore, women of child bearing potential must be advised to use effective contraception during treatment and for at least 30 days thereafter.
Croatian: Ženama reproduktivne dobi mora se preporučiti da koriste učinkovitu kontracepciju tijekom liječenja i najmanje 30 dana nakon završetka liječenja.
English: This medicinal product contains 2 mmol (43mg) sodium per 500 mg dose.
Croatian: Ovaj lijek sadrži 2 mmol (43 mg) natrija po dozi od 500 mg.
English: The duration of maintenance therapy is based on the risk of CMV disease, local treatment guidelines should be consulted.
Croatian: Trajanje terapije održavanja temelji se na riziku od CMV bolesti; potrebno je slijediti lokalne smjernice za liječenje.
English: Mutagenicity, teratogenicity, carcinogenicity, fertility, and contraception
Croatian: Mutagenost, teratogenost, kancerogenost, plodnost i kontracepcija
English: Pharmacokinetics of intravenous ganciclovir were also studied in infants and children with normal renal function and aged 9 months−12 years.
Croatian: Farmakokinetika intravenski primijenjenog ganciklovira ispitana je i u dojenčadi i djece s normalnom bubrežnom funkcijom u dobi od 9 mjeseci do 12 godina.
English: After reconstitution with 10 mL of water for injections, each mL provides 50 mg of ganciclovir.
Croatian: Nakon rekonstitucije s 10 ml vode za injekcije, jedan ml sadrži 50 mg ganciklovira.
English: • pentamidine - used for parasite or lung infections,
Croatian: • pentamidin - koristi se za liječenje parazitskih ili plućnih infekcija
English: • feeling depressed, anxious, confused or having abnormal thoughts
Croatian: • depresija, tjeskoba, smetenost, neuobičajene misli
English: Cymevene is a powder for solution for infusion.
Croatian: Cymevene je prašak za otopinu za infuziju.
English: Also do this for at least 30 days after Cymevene has been stopped.
Croatian: Koristite je i najmanje 30 dana nakon prestanka primjene lijeka Cymevene.
English: Patients should be closely monitored for didanosine toxicity (see section 4.4).
Croatian: Bolesnike treba pomno nadzirati zbog moguće toksičnosti didanozina (vidjeti dio 4.4).
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C, unless reconstitution and dilution have taken place in controlled and validated aseptic conditions.
Croatian: Vrijeme čuvanja ne smije biti dulje od 24 sata na temperaturi od 2 do 8°C, osim ako su rekonstitucija i razrjeđivanje provedeni u kontroliranim i validiranim aseptičnim uvjetima.
English: Patients treated with ganciclovir and didanosine, medicines known to be myelosuppressive or affecting renal function, should be closely monitored for signs of added toxicity (see section 4.5).
Croatian: Bolesnike koji se liječe ganciklovirom i didanozinom, lijekovima koji su poznati kao mijelosupresivi ili koji utječu na bubrežnu funkciju treba pomno nadzirati kako bi se uočili mogući znakovi povećane toksičnosti (vidjeti dio 4.5).
English: Further phosphorylation occurs by several cellular kinases to produce ganciclovir triphosphate, which is then slowly metabolised intracellularly.
Croatian: Djelovanjem nekoliko staničnih kinaza odvija se daljnja fosforilacija u ganciklovir trifosfat, koji se zatim polako metabolizira unutar stanice.
English: Cymevene and associated names (see Annex I) 500 mg powder for concentrate for solution for infusion
Croatian: NAZIV LIJEKA Cymevene i pridružena imena (vidjeti Prilog I.) 500 mg prašak za koncentrat za otopinu za infuziju
English: Rash*
Croatian: osip*
English: <{MM/YYYY}> <{DD/MM/YYYY}> <{DD month YYYY}>
Croatian: DATUM REVIZIJE TEKSTA <{MM/GGGG}> <{DD/MM/GGGG}> <{DD mjesec GGGG}>
English: {(Invented) name and associated names (see Annex I) strength pharmaceutical form} [See Annex I - To be completed nationally]
Croatian: {(Novoizumljeno) ime i pridružena imena (vidjeti Prilog I.) jačina farmaceutski oblik} [Vidjeti Prilog I. - ispunjava država članica]
English: Injection site reactions occur commonly in patients receiving ganciclovir.
Croatian: Reakcije na mjestu injekcije javljaju se često u bolesnika koji primaju ganciklovir.
English: • trimethoprim, trimethoprim/sulfamethoxazole, dapsone - used for bacterial infections,
Croatian: • trimetoprim, trimetoprim/sulfametoksazol, dapson - koriste se za liječenje bakterijskih infekcija
English: Cymevene contains 43 mg of sodium in each 500mg dose.
Croatian: Cymevene sadrži 43 mg natrija po dozi od 500 mg.
English: • changes to the way things taste
Croatian: • promjene osjeta okusa
English: • imipenem/cilastatin - used for bacterial infections,
Croatian: • imipenem/cilastatin - koristi se za liječenje bakterijskih infekcija
English: • you have kidney problems - your doctor will need to give you a lower dose and check your blood cell counts more often during treatment
Croatian: • ako imate tegoba s bubrezima - liječnik će Vam morati dati nižu dozu lijeka i češće provjeravati krvnu sliku tijekom liječenja
English: Single-dose glass vials of 10 mL with fluoro-resin laminated rubber stopper and aluminum closure with flip-off cap.
Croatian: Jednodozne staklene bočice volumena 10 ml s gumenim čepom obloženim slojem fluoro smole i aluminijskim zatvaračem sa zaštitnom kapicom.
English: Available in packs of 1 vial or 5 vials.
Croatian: Pakiranje od 1 bočice i 5 bočica.
English: In CMV-infected cells, ganciclovir is initially phosphorylated to ganciclovir monophosphate by the viral protein kinase, UL97.
Croatian: U stanicama zaraženima CMV-om ganciklovir se u početku fosforilira u ganciklovirfosfat uz pomoć virusne proteinske kinaze UL97.
English: Ganciclovir
Croatian: ganciklovir
English: The pharmacokinetic properties of ganciclovir have been evaluated in HIV- and CMV-seropositive patients, patients with AIDS and CMV retinitis, and in solid organ transplant patients.
Croatian: Farmakokinetička svojstva ganciklovira ispitana su u HIV- i CMV-seropozitivnih bolesnika, u bolesnika oboljelih od AIDS-a i CMV retinitisa te u bolesnika s presađenim solidnim organom.
English: Preparation of final diluted solution for infusion
Croatian: Priprema konačne razrijeđene otopine za infuziju
English: Avoid inhalation or direct contact of the powder contained in the vials or direct contact of the reconstituted solution with the skin or mucous membranes.
Croatian: Izbjegavajte udisanje ili izravan kontakt s praškom u bočicama ili izravan kontakt rekonstituirane otopine s kožom i sluznicama.
English: Children and adolescents There is limited information on how safe or effective Cymevene is in children under 12 years.
Croatian: Podaci o sigurnosti i djelotvornosti lijeka Cymevene u djece mlađe od 12 godina su ograničeni.
English: Viral resistance to ganciclovir can arise by selection of mutations in the viral kinase gene (UL97) responsible for ganciclovir monophosphorylation and/or the viral polymerase gene (UL54).
Croatian: Rezistencija virusa na ganciklovir može se razviti putem niza mutacija gena virusne kinaze (UL97), odgovorne za monofosforilaciju ganciklovira, i/ili gena virusne polimeraze (UL54).
English: The flip-off cap should be removed to expose the central portions of the rubber stopper.
Croatian: Zaštitnu kapicu treba ukloniti kako bi se oslobodio središnji dio gumenog čepa.
English: METHOD AND ROUTE(S) OF ADMINISTRATION For intravenous use after reconstitution and dilution.
Croatian: NAČIN I PUT(EVI) PRIMJENE LIJEKA Za primjenu u venu nakon rekonstitucije i razrjeđivanja.
English: If the blood cell counts are significantly reduced during therapy with ganciclovir, treatment with haematopoietic growth factors and/or discontinuation of treatment should be considered (see sections 4.4 and 4.8).
Croatian: Ako tijekom liječenja ganciklovirom dođe do značajnog pada broja krvnih stanica, potrebno je razmotriti liječenje hematopoetskim faktorima rasta i/ili prekid liječenja (vidjeti dijelove 4.4 i 4.8).
English: Treatment of CMV disease in adults and adolescents from 12 years of age with normal renal function
Croatian: Liječenje CMV bolesti u odraslih i adolescenata od navršenih 12 godina s normalnom bubrežnom funkcijom
English: • eczema, skin problems, itching
Croatian: • ekcem, problemi s kožom, svrbež
English: You may get the following symptoms if you have too much:
Croatian: Ako primite previše lijeka, mogu se pojaviti sljedeći simptomi:
English: As dosage modifications are recommended in patients with renal impairment, serum creatinine or estimated creatinine-clearance levels should be monitored.
Croatian: S obzirom da se preporučuje prilagodba doze u bolesnika s oštećenjem bubrežne funkcije, potrebno je pratiti razine serumskog kreatinina ili procijenjeni klirens kreatinina.
English: Such results are consistent with the positive mouse carcinogenicity study with ganciclovir.
Croatian: Takvi su rezultati u skladu s pozitivnim ishodom ispitivanja kancerogenosti ganciklovira u miševa.
English: Cymevene is indicated in adults and adolescents from 12 years of age for the:
Croatian: 4.1 Terapijske indikacije Cymevene je indiciran u odraslih i adolescenata od navršenih 12 godina za:
English: Probenecid given with oral ganciclovir resulted in statistically decreased renal clearance of ganciclovir, and led to clinically significant increased exposure.
Croatian: Probenecid Istodobna primjena probenecida s peroralnim oblikom ganciklovira rezultirala je statistički značajnim smanjenjem bubrežnog klirensa ganciklovira i dovela do klinički značajno povećane izloženosti.
English: Oral ganciclovir is no longer available but adverse reactions reported with its use can also be expected to occur in patients receiving intravenous ganciclovir.
Croatian: Peroralni oblik ganciklovira više nije dostupan, ali se nuspojave zabilježene kod njegove primjene mogu očekivati i u bolesnika koji primaju intravenski oblik ganciklovira.
English: During the course of the study, 29/46 ganciclovir-treated patients had neutropenia, compared with 9/43 control patients (p < 0.1).
Croatian: Tijekom ispitivanja, neutropenija je nastupila u 29/46 bolesnika liječenih ganciklovirom u odnosu na 9/43 kontrolnih bolesnika (p < 0,1).
English: Do not administer by rapid or bolus intravenous injection because the resulting excessive plasma levels may increase the toxicity of ganciclovir.
Croatian: Ne smije se primijeniti brzom niti bolusnom intravenskom injekcijom jer prekomjerne razine lijeka u plazmi do kojih dolazi kod takve primjene mogu povećati toksičnost ganciklovira.
English: 4.4 Special warnings and precautions for use
Croatian: 4.4 Posebna upozorenja i mjere opreza pri uporabi Križna preosjetljivost
English: Therefore, breastfeeding must be discontinued during treatment with ganciclovir (see section 4.3).
Croatian: Stoga se tijekom liječenja ganciklovirom dojenje mora prekinuti (vidjeti dio 4.3).