FrancophonIA/ELRC3.0 huggingface dataset:
English: Targocid and associated names (see Annex I) is indicated in adults and in children from birth for the parenteral treatment of the following infections (see sections 4.2, 4.4 and 5.1):
Slovenian: Zdravilo Targocid in povezana imena (glejte Prilogo I) je indicirano pri odraslih in otrocih od rojstva za parenteralno zdravljenje naslednjih okužb (glejte poglavja 4.2, 4.4 in 5.1):
English: Solvent: water for injections.
Slovenian: Vehikel: voda za injekcije.
English: • It will be given by injection into a vein (intravenous use) or muscle (intramuscular use).
Slovenian: • Dobili ga boste z injekcijo v veno (intravenska uporaba) ali v mišico (intramuskularna uporaba).
English: On this basis it is expected that in most instances teicoplanin will be used to treat severe infections in patients for whom standard antibacterial activity is considered to be unsuitable.
Slovenian: Na tej podlagi je mogoče pričakovati, da bo teikoplanin večinoma uporabljen za zdravljenje hudih okužb pri bolnikih, za katere je standardno protibakterijsko delovanje ocenjeno kot neprimerno.
English: Other medicines and Targocid
Slovenian: Druga zdravila in zdravilo Targocid
English: Microorganism
Slovenian: Mikroorganizem
English: In one case agitation occurred in a 29-day-old newborn who had been administered 400 mg intravenously (95 mg/kg).
Slovenian: V enem primeru se je pojavila agitacija pri 29 dni starem novorojenčku, ki je prejel 400 mg intravensko (95 mg/kg).
English: Measurement of serum concentrations
Slovenian: Merjenje koncentracije v serumu
English: Teicoplanin did not show any potential to cause antigenicity (in mice, guinea-pigs or rabbits), genotoxicity or local irritancy.
Slovenian: Teikoplanin ni pokazal potenciala za antigenost (pri miših, morskih prašičkih ali kuncih), genotoksičnost ali lokalno draženje.
English: If an allergic reaction to teicoplanin occurs, treatment should be discontinued immediately and appropriate emergency measures should be initiated.
Slovenian: Če se pojavi alergijska reakcija na teikoplanin, je treba zdravljenje nemudoma prekiniti in uvesti ustrezne nujne ukrepe.
English: b Isolates with MIC values above the susceptible breakpoint are very rare or not yet reported.
Slovenian: b Izolati z MIC nad mejno vrednostjo občutljivosti so zelo redki ali še niso opisani.
English: What you need to know before you are given Targocid 3.
Slovenian: Kaj morate vedeti, preden boste dobili zdravilo Targocid 3.
English: The final solution is isotonic with plasma and has a pH of 7.2-7.8.
Slovenian: Končna raztopina je izotonična s plazmo in ima pH od 7,2 do 7,8.
English: a Glycopeptide MICs are method dependent and should be determined by broth microdilution (reference ISO 20776).
Slovenian: Odporni a MIC za glikopeptide so odvisne od metode in jih je treba določati z mikrodilucijo bujona (referenca ISO 20776).
English: When administered by oral route at 250 or 500 mg single dose to healthy subjects, teicoplanin is not detected in serum or urine but only recovered in feces (about 45% of the administered dose) as unchanged medicinal product.
Slovenian: Po peroralni uporabi enkratnega odmerka 250 ali 500 mg pri zdravih osebah se teikoplanin ni pojavil v serumu ali urinu, temveč le v blatu (približno 45 % uporabljenega odmerka) kot nespremenjeno zdravilo.
English: Tell your doctor, pharmacist or nurse if you are using, have recently used or might use any other medicines.
Slovenian: Obvestite svojega zdravnika, farmacevta ali medicinsko sestro, če uporabljate, ste pred kratkim uporabljali ali pa boste morda začeli uporabljati katero koli drugo zdravilo.
English: The modification is based on exchange of the terminal D-alanine-D-alanine function of the aminoacid chain in a murein precursor with D-Ala-D-lactate, thus reducing the affinity to vancomycin.
Slovenian: Sprememba temelji na zamenjavi terminalnega D-alanin-D-alaninskega dela aminokislinske verige v mureinskem predhodniku z D-Ala-D-laktatom; to zmanjša afiniteto za vankomicin.
English: The rational use of teicoplanin should take into account the bacterial spectrum of activity, the safety profile and the suitability of standard antibacterial therapy to treat the individual patient.
Slovenian: Za racionalno uporabo teikoplanina je treba upoštevati bakterijski spekter delovanja, varnostne značilnosti in primernost standardnega protibakterijskega zdravljenja za zdravljenje posameznega bolnika.
English: After intramuscular administration, the bioavailability of teicoplanin (as compared to intravenous administration) is almost complete (90%).
Slovenian: Po intramuskularni uporabi je biološka uporabnost teikoplanina (v primerjavi z intravensko uporabo) skoraj popolna (90 %).
English: a No current data were available when the tables were published.
Slovenian: a Ob objavi preglednic ni bilo na voljo trenutnih podatkov.
English: Also, some medicines can affect the way Targocid works.
Slovenian: Prav tako lahko nekatera zdravila vplivajo na delovanje zdravila Targocid.
English: The total and renal clearances of teicoplanin depends on the creatinine clearance.
Slovenian: Celotni in ledvični očistek teikoplanina sta odvisna od očistka kreatinina.
English: Under this regimen blood creatinine values should be monitored in addition to the recommended periodic haematological examination.
Slovenian: Med uporabo te sheme je treba poleg priporočenih rednih hematoloških pregledov kontrolirati tudi kreatinin v krvi.
English: Chemical and physical in-use stability of the reconstituted solution prepared as recommended has been demonstrated for 24 hours at 2 to 8°C.
Slovenian: Kemična in fizikalna stabilnost v skladu s priporočili pripravljene raztopine med uporabo sta dokazani za 24 ur pri temperaturi od 2 do 8 °C.
English: Pharmacotherapeutic group: Glycopeptide Antibacterials, ATC code: J01XA 02
Slovenian: Farmakoterapevtska skupina: glikopeptidni antibiotiki, oznaka ATC: J01XA 02
English: However, a prior history of "red man syndrome" with vancomycin is not a contraindication to the use of teicoplanin.
Slovenian: Anamneza "sindroma rdečega moža" med uporabo vankomicina ni kontraindikacija za uporabo teikoplanina.
English: • Peritoneal dialysis solution containing 1.36% or 3.86% glucose solution.
Slovenian: • raztopina za peritonealno dializo, ki vsebuje 1,36 % ali 3,86 % raztopine glukoze.
English: Adults and elderly patients with impaired renal function Dose adjustment is not required until the fourth day of treatment, at which time dosing should be adjusted to maintain a serum trough concentration of at least 10 mg/L.
Slovenian: Odrasli in starejši bolniki z okvarjenim delovanjem ledvic Odmerka ni treba prilagoditi do četrtega dne zdravljenja; tedaj je treba odmerjanje prilagoditi tako, da je vzdrževana najnižja koncentracija v serumu vsaj 10 mg/l.
English: S. aureus with vancomycin MIC values of 2 mg/mL are on the border of the wild type MIC distribution and there may be an impaired clinical response.
Slovenian: S. aureus z vrednostjo MIC za vankomicin 2 mg/ml je na meji porazdelitve MIC divjega tipa in klinični odziv je lahko okrnjen.
English: 12 hours, by injection into a vein.
Slovenian: na 12 ur z injekcijo v veno ali mišico.
English: Unchanged teicoplanin is mainly excreted by urinary route (80% within 16 days) while 2.7% of the administered dose is recovered in feces (via bile excretion) within 8 days following administration.
Slovenian: Nespremenjeni teikoplanin se v glavnem izloči v urinu (80 % v 16 dneh), 2,7 % uporabljenega odmerka pa se pojavi v blatu (preko izločanja v žolč) v 8 dneh po aplikaciji.
English: If teicoplanin is administered in combination therapy with other antibiotics, the preparation must be administered separately.
Slovenian: Če je teikoplanin uporabljen v kombiniranem zdravljenju z drugimi antibiotiki, je pripravek treba aplicirati ločeno.
English: Resistance rate can vary depending on the actual streptococcus species
Slovenian: Delež odpornosti se lahko razlikuje glede na dejansko vrsto streptokoka.
English: The volume of distribution at steady-state (Vss) varies from 0.7 to 1.4 mL/kg.
Slovenian: Volumen porazdelitve v stanju dinamičnega ravnovesja (Vss) je od 0,7 do 1,4 ml/kg.
English: Targocid can be used to treat some infections caused by ‘Clostridium difficile' bacteria in the gut.
Slovenian: Zdravilo Targocid se lahko uporablja za zdravljenje nekaterih okužb, ki jih v črevesu povzroča bakterija Clostridium difficile.
English: Superinfection
Slovenian: Superinfekcije
English: d A MIC with a comment but without an accompanying S, I or R categorisation may be reported.
Slovenian: d Navedena je lahko MIC s komentarjem, a brez spremljajoče opredelitve S, I ali R.
English: • The reduced sensitivity or resistance of staphylococci to teicoplanin is based on the overproduction of murein precursors to which teicoplanin is bound.
Slovenian: • Manjša občutljivost ali odpornost stafilokokov na teikoplanin temelji na prekomerni tvorbi mureinskih predhodnikov, na katere se veže teikoplanin.
English: The dose and duration of treatment should be adjusted according to the underlying type and severity of infection and clinical response of the patient, and patient factors such as age and renal function.
Slovenian: Odmerek in trajanje zdravljenja je treba prilagoditi glede na vrsto in izrazitost osnovne okužbe, bolnikov klinični odziv ter dejavnike, povezane z bolnikom, kot sta na primer starost in delovanje ledvic.
English: If superinfection occurs during therapy, appropriate measures should be taken.
Slovenian: Če se med zdravljenjem pojavi superinfekcija, je treba ustrezno ukrepati.
English: • raised blood levels of liver enzymes
Slovenian: • zvišana raven jetrnih encimov v krvi
English: The resistance breakpoint for S. aureus has been reduced to 2 mg/mL to avoid reporting of GISA isolates intermediate as serious infections with GISA isolates are not treatable with increased doses of vancomycin or teicoplanin.
Slovenian: Mejna vrednost odpornosti za S. aureus je bila znižana na 2 mg/ml, da bi preprečili prijavljanje intermediarnih izolatov GISA kot resnih okužb z izolati GISA; teh ni mogoče zdraviti z večjimi odmerki vankomicina ali teikoplanina.
English: Transaminases increased (transient abnormality of transaminases), blood alkaline phosphatase increased (transient abnormality of alkaline phosphatase), blood creatinine increased (transient rise of serum creatinine)
Slovenian: Preiskave zvišanje transaminaz (prehodna nenormalnost transaminaz), zvišanje alkalne fosfataze v krvi (prehodna nenormalnost alkalne fosfataze), zvišanje kreatinina v krvi (prehodno zvišanje kreatinina v serumu)
English: Cases of accidental administration of excessive doses to paediatric patients have been reported.
Slovenian: Opisani so primeri nenamerne uporabe prekomernih odmerkov pri pediatričnih bolnikih.
English: Staphylococcus aureus (including methicillin-resistant strains) Streptococcus agalactiae
Slovenian: Staphylococcus aureus (vključno s sevi, odpornimi proti meticilinu) Streptococcus agalactiae
English: It is not suitable for use as a single agent for the treatment of some types of infections unless the pathogen is already documented and known to be susceptible or there is a high suspicion that the most likely pathogen(s) would be suitable for treatment with teicoplanin.
Slovenian: Ni primeren za monoterapijo nekaterih vrst okužb, razen če je patogen že dokumentirano in znano občutljiv, ali če obstaja močan sum, da je najverjetnejši patogen primeren/so najverjetnejši patogeni primerni za zdravljenje s teikoplaninom.
English: During maintenance treatment, teicoplanin trough serum concentrations monitoring may be performed at least once a week to ensure that these concentrations are stable.
Slovenian: Med vzdrževalnim zdravljenjem je treba najnižjo koncentracijo teikoplanina v serumu kontrolirati vsaj enkrat na teden, da bi preverili stabilnost te koncentracije.
English: In clinical studies, teicoplanin has been administered to many patients already receiving various medications including other antibiotics, antihypertensives, anaesthetic agents, cardiac medicinal products and antidiabetic agents without evidence of adverse interaction.
Slovenian: V kliničnih študijah so teikoplanin dajali številnim bolnikom, ki so že prejemali različna zdravila, vključno z drugimi antibiotiki, antihipertenzivi, anestetiki, zdravili za srce in antidiabetičnimi zdravili, ne da bi se pojavila kakšna neželena medsebojna delovanja.
English: Two metabolites are formed probably by hydroxylation and represents 2 to 3% of the administered dose.
Slovenian: Nastaneta dva presnovka (verjetno s hidroksilacijo), ki predstavljata od 2 do 3 % uporabljenega odmerka.
English: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Slovenian: V spodnji preglednici so navedeni vsi neželeni učinki, ki so se pojavili z večjo incidenco kot pri placebu in pri več kot enem bolniku, in sicer po naslednjem dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: What Targocid is and what it is used for
Slovenian: Kaj je zdravilo Targocid in za kaj ga uporabljamo
English: It contains a medicine called ‘teicoplanin'.
Slovenian: Vsebuje zdravilno učinkovino, ki se imenuje "teikoplanin".
English: If you have more Targocid than you should
Slovenian: Če ste dobili večji odmerek zdravila Targocid, kot bi smeli
English: The ability to drive or use machines may be affected.
Slovenian: Sposobnost vožnje in upravljanja s stroji se lahko poslabša.
English: • infective endocarditis,
Slovenian: • infekcijski endokarditis,
English: Species for which acquired resistance may be a problem Aerobic Gram-positive bacteria Enterococcus faecium
Slovenian: Vrste, pri katerih je lahko problem pridobljena odpornost Aerobne grampozitivne bakterije Enterococcus faecium
English: • kidney problems or changes in the way your kidneys work - shown in tests
Slovenian: • težave z ledvicami ali spremembe v delovanju ledvic - pokažejo se na preiskavah
English: A higher total clearance (15.8 mL/h/kg for neonates, 14.8 mL/h/kg for a mean age 8 years) and a shorter elimination half-life (40 hours neonates; 58 hours for 8 years) are observed compared to adult patients.
Slovenian: V primerjavi z odraslimi bolniki so opažali večji celotni očistek (15,8 ml/h/kg pri novorojenčkih, 14,8 ml/h/kg za povprečno starost 8 let) in krajši eliminacijski razpolovni čas (40 ur pri novorojenčkih, 58 ur pri 8-letnikih).
English: Targocid contains sodium This medicine contains less than 1 mmol sodium (23 mg) per vial and is essentially ‘sodium-free'.
Slovenian: Zdravilo Targocid vsebuje natrij To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na vialo in je praktično "brez natrija".
English: Following repeated parenteral administration to the rat and dog, effects on the kidney were observed and were shown to be dose-dependent and reversible.
Slovenian: Po ponavljajoči se parenteralni uporabi pri podganah in psih so opažali vplive na ledvice; izkazalo se je, da so ti vplivi odvisni od odmerka in reverzibilni.
English: For storage conditions of the reconstituted/diluted medicinal product, see section 6.3.
Slovenian: Za pogoje shranjevanja pripravljenega/redčenega zdravila glejte poglavje 6.3.
English: However, if you think you have been given too much Targocid or if you are agitated, talk to your doctor or nurse straight away.
Slovenian: Toda če menite, da ste dobili preveč zdravila Targocid, ali če ste vznemirjeni, se takoj posvetujte z zdravnikom ali medicinsko sestro.
English: Infusion related reactions can be limited if the daily dose is not given via bolus injection but infused over a 30-minute period.
Slovenian: Z infundiranjem povezane reakcije je mogoče omejiti, če dnevni odmerek ni uporabljen v bolusni injekciji, temveč je infundiran v obdobju 30 minut.
English: Gently roll the vial between the hands until the powder is completely dissolved.
Slovenian: Vialo nežno vrtite med dlanmi, dokler ni prašek povsem raztopljen.
English: There are a limited amount of data from the use of teicoplanin in pregnant women.
Slovenian: Podatkov o uporabi teikoplanina pri nosečnicah je malo.
English: Teicoplanin and aminoglycoside solutions are incompatible and must not be mixed for injection; however, they are compatible in dialysis fluid and may be freely used in the treatment of CAPD-related peritonitis.
Slovenian: Raztopine teikoplanina in aminoglikozidov niso kompatibilne in se jih za injiciranje ne sme mešati; kompatibilne pa so v dializni tekočini in jih je mogoče prosto uporabljati za zdravljenje peritonitisa, povezanega s CAPD.
English: Targocid and associated names (see Annex I) has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo Targocid in povezana imena (glejte Prilogo I) ima blag vpliv na sposobnost vožnje in upravljanja s stroji.
English: Children (2 months to 12 years):
Slovenian: Otroci (od 2 mesecev do 12 let):
English: What you need to know before you are given Targocid
Slovenian: Kaj morate vedeti, preden boste dobili zdravilo Targocid
English: Babies (from birth to the age of 2 months)
Slovenian: Dojenčki (od rojstva do starosti 2 mesecev)
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with teicoplanin should be made taking into account the benefit of breastfeeding to the child and the benefit of teicoplanin therapy to the mother.
Slovenian: Pri odločitvi za nadaljevanje/prekinitev dojenja oz. za nadaljevanje/prekinitev zdravljenja s teikoplaninom je treba upoštevati korist dojenja za otroka in korist zdravljenja s teikoplaninom za mater.
English: Rare (may affect up to 1 in 1,000 people) • infection (abcess).
Slovenian: Redki (pojavijo se lahko pri največ 1 od 1000 oseb) • okužba (absces)
English: • It can also be given as a infusion through a drip into a vein.
Slovenian: • Dobite ga lahko tudi kot kapalno infuzijo v veno.
English: • sodium chloride 9 mg/mL (0.9%) solution
Slovenian: • raztopina natrijevega klorida 9 mg/ml (0,9 %)
English: Targeted trough concentrations during maintenance
Slovenian: Ciljna najnižja koncentracija med vzdrževanjem
English: • blistering of the skin, mouth, eyes or genitals - these may be signs of something called ‘toxic epidermal necrolysis' or ‘Stevens-Johnson syndrome' Tell your doctor or nurse straight away, if you notice any of the side effects above.
Slovenian: • mehurji na koži, v ustih, na očeh ali spolovilih - lahko so znak motnje, imenovane "toksična epidermalna nekroliza" ali "Stevens-Johnsonov sindrom" Če opazite katerega od omenjenih neželenih učinkov, takoj obvestite zdravnika ali medicinsko sestro.
English: Periodic haematological examinations are recommended during treatment, including complete cell blood count.
Slovenian: Med zdravljenjem so potrebni redni hematološki pregledi, vključno s celotno krvno sliko.
English: Teicoplanin trough serum concentrations should be monitored at steady state after completion of the loading dose regimen in order to ensure that a minimum trough serum concentration has been reached:
Slovenian: Najnižjo koncentracijo teikoplanina v serumu je treba kontrolirati v stanju dinamičnega ravnovesja po dokončanju sheme polnilnih odmerkov in tako preveriti, da je bila dosežena minimalna najnižja koncentracija v serumu:
English: These include aminoglycosides, colistin, amphotericin B, ciclosporin, cisplatin, furosemide, and ethacrynic acid (see section 4.4).
Slovenian: Med takšna spadajo aminoglikozidi, kolistin, amfotericin B, ciklosporin, cisplatin, furosemid in etakrinska kislina (glejte poglavje 4.4).
English: There is no information on the excretion of teicoplanin in animal milk.
Slovenian: Informacij o izločanju teikoplanina v mleko pri živalih ni.
English: Gram-positive anaerobes except Clostridium difficile PK/PD (Non-species related) breakpoints c,d
Slovenian: Grampozitivni anaerobi razen Clostridium difficile FK/FD mejne vrednosti (nepovezane z vrsto) c,d
English: Cross-resistance between teicoplanin and the glycoprotein vancomycin may occur.
Slovenian: Pojavi se lahko navzkrižna odpornost med teikoplaninom in glikoproteinom vankomicinom.
English: • difficulty in breathing or wheezing (bronchospasm)
Slovenian: • težko dihanje ali piskajoče dihanje (bronhospazem)
English: Adults and children (12 years and over) with no kidney problems Skin and soft tissue, lung and urinary tract infections
Slovenian: Odrasli in otroci (stari 12 let ali več), ki nimajo težav z ledvicami Okužbe kože in mehkih tkiv, pljuč in sečil
English: In the elderly population the teicoplanin pharmacokinetics is not modified unless in case of renal impairment.
Slovenian: • Starejši bolniki: V starejši populaciji se farmakokinetika teikoplanina ne spremeni razen v primeru okvare ledvic.
English: Studies to investigate the potential to cause ototoxicity in the guinea-pig indicate that a mild impairment of cochlear and vestibular function is possible, in the absence of morphological damage.
Slovenian: Študije za preučitev možnosti za ototoksičnost pri morskih prašičkih kažejo, da se lahko pojavi blaga okvara kohlearnega in vestibularnega delovanja, in sicer v odsotnosti morfološke okvare.
English: - Infective endocarditis
Slovenian: - Infekcijski endokarditis
English: Teicoplanin has a low total clearance in the range of 10 to 14 mL/h/kg and a renal clearance in the range of 8 to 12 mL/h/kg indicating that teicoplanin is mainly excreted by renal mechanisms.
Slovenian: Teikoplanin ima nizek celotni očistek v razponu od 10 do 14 ml/h/kg in ledvični očistek v razponu od 8 do 12 ml/h/kg; to kaže, da se teikoplanin v glavnem izloči z ledvičnimi mehanizmi.
English: In rare cases (even at the first dose), red man syndrome (a complex of symptoms including pruritus, urticaria, erythema, angioneurotic oedema, tachycardia, hypotension, dyspnoea) has been observed.
Slovenian: V redkih primerih so (celo že po prvem odmerku) opažali sindrom rdečega moža (skupek simptomov, ki vključuje srbenje, urtikarijo, eritem, angionevrotični edem, tahikardijo, hipotenzijo, dispnejo).
English: Patients in continuous ambulatory peritoneal dialysis (CAPD) After a single intravenous loading dose of 6 mg/kg bodyweight, 20 mg/L is administered in the bag of the dialysis solution in the first week, 20 mg/L in different bags the second week and then 20 mg/L in the overnight bag in the third week.
Slovenian: Bolniki na kontinuirani ambulantni peritonealni dializi (CAPD) Po enkratnem intravenskem polnilnem odmerku 6 mg/kg telesne mase je treba dati 20 mg/l v vsako vrečko dializne tekočine prvi teden, 20 mg/l v vsako drugo vrečko drugi teden in 20 mg/l v vrečko za čez noč tretji teden.
English: Targocid is used in adults and children (including newborn babies) to treat bacterial infections of: the skin and underneath the skin - sometimes called ‘soft tissue' the bones and joints the lung the urinary tract the heart - sometimes called ‘endocarditis' the abdominal wall - peritonitis the blood, when caused by any of the conditions listed above
Slovenian: Zdravilo Targocid se uporablja pri odraslih in otrocih (vključno z novorojenčki) za zdravljenje bakterijskih okužb: kože in podkožja - to včasih imenujemo "mehka tkiva", kosti in sklepov, pljuč, sečil, srca - to včasih imenujemo "endokarditis", trebušne stene - peritonitis, krvi, če je to posledica katere koli od zgoraj omenjenih bolezni.
English: • you have a flushing of your upper part of your boby (red man syndrome)
Slovenian: • če se vam pojavlja zardevanje zgornjega dela telesa ("sindrom rdečega moža"),
English: • Renal impairment:
Slovenian: • Okvara ledvic:
English: equisimilis a (Group C & G streptococci)
Slovenian: equisimilis a (Streptokoki skupin C in G)
English: Since data on safety are limited, patients should be carefully monitored for adverse reactions when teicoplanin doses of 12mg/kg body weight twice a day are administered.
Slovenian: Ker je podatkov malo, je treba bolnike skrbno nadzirati glede neželenih učinkov, če je teikoplanin uporabljen v odmerkih 12 mg/kg telesne mase dvakrat na dan.