FrancophonIA/ELRC3.0 huggingface dataset:
English: In the early stages of treatment, some people may faint, especially when getting up from a lying or sitting position.
Slovenian: Na začetku zdravljenja lahko nekateri bolniki omedlijo, še posebej ob vstajanju iz ležečega ali sedečega položaja.
English: In elderly patients (between 65 and 85 years of age), exposure to asenapine is approximately 30 % higher than in younger adults.
Slovenian: Pri starejših bolnikih (starih med 65 in 85 let) je izpostavljenost asenapinu približno za 30 % večja kot pri drugih mlajših odraslih bolnikih.
English: Do not take Sycrest If you are allergic to asenapine or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Sycrest Če ste alergični na asenapin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: This leaflet was last revised in {month/YYYY}.
Slovenian: Navodilo je bilo nazadnje revidirano {MM/LLLL}.
English: Other side effects reported with this medicine include:
Slovenian: Drugi neželeni učinki, o katerih so poročali pri uporabi tega zdravila, so:
English: Since Sycrest can lower blood pressure, care should be taken when Sycrest is taken with other medicines that lower blood pressure.
Slovenian: Ker lahko zdravilo Sycrest zniža krvni tlak, je potrebna previdnost pri jemanju zdravila Sycrest z drugimi zdravili, ki tudi znižujejo krvni tlak.
English: All ADRs are listed by system organ class and frequency; very common (≥ 1/10), common ( 1/100 to < 1/10), uncommon ( 1/1,000 to < 1/100), rare ( 1/10,000 to < 1/1,000) and not known (cannot be estimated from the available data).
Slovenian: Vsi neželeni učinki so razvrščeni po organskih sistemih in po pogostnosti; zelo pogosti (≥ 1/10), pogosti ( 1/100 do < 1/10), občasni ( 1/1.000 do < 1/100), redki ( 1/10.000 do < 1/1.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: Asenapine is rapidly distributed and has a large volume of distribution (approximately 20-25 L/kg), indicating extensive extravascular distribution.
Slovenian: Asenapin se hitro porazdeli in ima velik porazdelitveni volumen (približno 20-25 l/kg), kar kaže na njegovo obsežno porazdelitev zunaj žilja.
English: Patients should be advised to avoid alcohol while taking Sycrest.
Slovenian: Bolnikom je treba svetovati, naj se med jemanjem zdravila Sycrest izogibajo alkoholu.
English: Other serious ADRs are discussed in more detail in section 4.4.
Slovenian: Drugi resni neželeni učinki so podrobneje opisani v poglavju 4.4.
English: There are no adequate data from the use of Sycrest in pregnant women.
Slovenian: Ni zadostnih podatkov o uporabi zdravila Sycrest pri nosečnicah.
English: Packs may contain 20, 60 or 100 tablets.
Slovenian: Pakiranja lahko vsebujejo 20, 60 ali 100 tablet.
English: In a mass balance study, the majority of the radioactive dose was recovered in urine (about 50 %) and faeces (about 40 %), with only a small amount excreted in faeces (5-16 %) as unchanged compound.
Slovenian: V študiji masne bilance so večino radioaktivnega odmerka našli v urinu (približno 50 %) in v blatu (približno 40 %), le majhna količina se ga je izločila v obliki nespremenjene spojine z blatom (5-16 %).
English: Sycrest should not be used during pregnancy unless the clinical condition of the woman requires treatment with asenapine and only if the potential benefit outweighs the potential risk to the foetus.
Slovenian: Zdravila Sycrest se med nosečnostjo ne sme uporabljati, razen če zdravstveno stanje ženske zahteva zdravljenje z asenapinom in le, če njegove možne koristi odtehtajo potencialno tveganje za plod.
English: Asenapine demonstrated superior efficacy to placebo in the reduction of manic symptoms over 3 weeks.
Slovenian: Asenapin je pokazal večjo učinkovitost od placeba kar zadeva zmanjšanje maničnih simptomov v obdobju 3 tednov.
English: - The exact amount is shown on your Sycrest tablet pack.
Slovenian: - Natančna količina je navedena na pakiranju tablet Sycrest.
English: Long term safety in this population was explored in a 50-week, open-label, uncontrolled extension study.
Slovenian: Dolgoročno varnost so pri tej populaciji raziskali v odprti, nenadzorovani 50-tedenski podaljšani študiji.
English: Check with your doctor or pharmacist before taking Sycrest:
Slovenian: Posvetujte se z zdravnikom ali farmacevtom, preden začnete jemati zdravilo Sycrest:
English: Serious hypersensitivity reactions have been reported.
Slovenian: Poročali so o resnih preobčutljivostnih reakcijah.
English: The tablet will dissolve in saliva within seconds.
Slovenian: Tableta se bo v nekaj sekundah raztopila v slini.
English: Do not use this medicine after the expiry date which is stated on the blister and on the carton.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu in škatli.
English: In the same study, treatment with paroxetine 20 mg daily decreased the DX/DM ratio to 0.032.
Slovenian: V isti študiji je zdravljenje s paroksetinom v odmerku 20 mg na dan zmanjšalo razmerje DX/DM na 0,032.
English: Children and adolescents Sycrest is not recommended for use in patients below the age of 18 years.
Slovenian: Otroci in mladostniki Uporabe zdravila Sycrest ne priporočamo pri bolnikih, mlajših od 18 let.
English: If this combination is deemed necessary, the lowest effective dose of each treatment should be prescribed.
Slovenian: Če menite, da je njihova sočasna uporaba resnično potrebna, morate bolniku predpisati najmanjši še učinkovit odmerek vsakega od zdravil.
English: A statistically significant difference between asenapine and placebo was seen as early as day 2.
Slovenian: Statistično pomembna razlika med asenapinom in placebom se je pokazala že 2. dan.
English: N.V. Organon, Kloosterstraat 6, NL-5349 AB Oss, The Netherlands
Slovenian: Organon, Kloosterstraat 6, NL-5349 AB Oss, Nizozemska
English: Asenapine was excreted in milk of rats during lactation.
Slovenian: Asenapin se je izločal v mleko pri podganah v času laktacije.
English: In in vitro assays asenapine acts as an antagonist at these receptors.
Slovenian: V testiranjih in vitro se asenapin obnaša kot antagonist teh receptorjev.
English: The table is based on adverse reactions reported during clinical trials and/or post-marketing use.
Slovenian: Ta preglednica temelji na neželenih učinkih, ki so bili poročani v kliničnih preskušanjih in/ali v obdobju trženja zdravila.
English: What you need to know before you take Sycrest
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Sycrest
English: Sycrest may cause low blood pressure.
Slovenian: Zdravilo Sycrest lahko povzroči padec krvnega tlaka.
English: If you stop taking Sycrest, you will lose the effects of this medicine.
Slovenian: Če prenehate jemati zdravilo Sycrest, boste s tem izgubili tudi njegove zdravilne učinke.
English: Long term efficacy could not be established in a 50-week, uncontrolled, open-label extension trial.
Slovenian: Dolgoročne učinkovitosti v odprtem, nenadzorovanem 50-tedenskem podaljšanem preskušanju niso mogli dokazati.
English: Asenapine is highly bound (95 %) to plasma proteins, including albumin and α1-acid glycoprotein.
Slovenian: Asenapin se v velikem odstotku (95 %) veže na plazemske beljakovine, vključno z albuminom in α1-kislim glikoproteinom.
English: You should not stop taking this medicine, unless your doctor tells you as your symptoms may return.
Slovenian: Z jemanjem zdravila torej ne smete prenehati, če vam to ne svetuje zdravnik, saj se vam simptomi lahko povrnejo.
English: Manufacturer Organon (Ireland) Ltd. Drynam Road, Swords Co. Dublin, Ireland
Slovenian: Izdelovalec Organon (Ireland) Ltd. Drynam Road, Swords Co. Dublin, Irska
English: Also contact your doctor immediately if any of these conditions develops or worsens while using Sycrest.
Slovenian: Z zdravnikom se takoj posvetujte tudi, če se vam katera od teh bolezni ali motenj pojavi ali poslabša med uporabo zdravila Sycrest.
English: In addition, histopathological examination of the eyes from dogs treated chronically with asenapine did not reveal any signs of ocular toxicity, demonstrating the absence of a phototoxic hazard.
Slovenian: Poleg tega tudi histopatološki pregled oči psov, kronično zdravljenih z asenapinom, ni pokazal nobenih znakov toksičnosti za oči, kar dokazuje, da ni tveganja za fototoksičnost zdravila.
English: Repeat-dose toxicity studies in rat and dog showed mainly dose-limiting pharmacological effects, such as sedation.
Slovenian: Študije toksičnosti pri ponavljajočih se odmerkih pri podganah in psih so pokazale predvsem farmakološke učinke za omejitev odmerka, na primer sedacijo.
English: Your dose may need to be adjusted.
Slovenian: Morda bo potrebna prilagoditev odmerka.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Sycrest in one or more subsets of the paediatric population in bipolar I disorder (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila obvezo za predložitev rezultatov študij z zdravilom Sycrest za eno ali več podskupin pediatrične populacije pri bipolarni motnji I (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Elderly patients are particularly at risk for experiencing orthostatic hypotension (see section 4.8).
Slovenian: Pri starostnikih je še posebej veliko tveganje za pojav ortostatske hipotenzije (glejte poglavje 4.8).
English: However, based on its receptor pharmacology, it is proposed that the efficacy of asenapine is mediated through a combination of antagonist activity at D2 and 5-HT2A receptors.
Slovenian: Na podlagi farmakologije njegovih receptorjev pa predpostavljamo, da njegovo delovanje temelji na kombinaciji antagonističnega delovanja na receptorje D2 in 5-HT2A.
English: Sycrest is not advised if you are unable to take the tablet as described below.
Slovenian: Zdravila Sycrest ne priporočamo osebam, ki tablet ne morejo jemati tako, kot je opisano spodaj.
English: Very common side effects (may affect more than 1 in 10 people) - anxiety - sleepiness
Slovenian: Zelo pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 10 bolnikov) - tesnoba - zaspanost
English: The dose can be increased to 10 mg twice daily based on individual clinical response and tolerability.
Slovenian: Odmerek se lahko zviša na 10 mg dvakrat na dan na podlagi kliničnega odziva in prenašanja zdravila posameznika.
English: Do not take Sycrest while you are pregnant, unless your doctor tells you so.
Slovenian: Zdravila Sycrest ne smete jemati med nosečnostjo, razen če vam to svetuje vaš zdravnik.
English: In subcutaneous carcinogenicity studies in rats and mice, no increases in tumour incidences were observed.
Slovenian: V študijah subkutane kancerogenosti pri podganah in miših niso opazili nobenega povečanja incidence tumorjev.
English: Cerebrovascular events have been reported in patients treated with asenapine but there is no evidence of any excess incidence over what is expected in adults between 18 and 65 years of age.
Slovenian: Pri bolnikih, zdravljenih z asenapinom, so poročali o možgansko-žilnih dogodkih, vendar ni dokazov za večjo incidenco od tiste, ki je že pričakovana pri odraslih, starih od 18 do 65 let.
English: - Gently remove the tablet (Figure 2).
Slovenian: - Tableto previdno vzemite ven (slika 2).
English: - The other ingredients are gelatin and mannitol (E421).
Slovenian: - Pomožni snovi sta želatina in manitol (E421).
English: The less than proportional increase of Cmax and AUC with dose may be attributed to limitations in the absorption capacity from the oral mucosa following sublingual administration.
Slovenian: Manj kot sorazmerno povečevanje vrednosti Cmax in AUC z odmerkom lahko pripišemo omejitvam v absorpcijski kapaciteti ustne sluznice pri podjezični uporabi.
English: Other medicines and Sycrest
Slovenian: Druga zdravila in zdravilo Sycrest
English: Sycrest with food, drink and alcohol Do not eat or drink for 10minutes after taking this medicine.
Slovenian: Zdravilo Sycrest skupaj s hrano, pijačo in alkoholom Še 10 minut po zaužitju tega zdravila ne smete jesti ali piti.
English: It is not known whether asenapine or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se asenapin in njegovi presnovki izločajo v materino mleko.
English: Asenapine is not indicated for the treatment of children and adolescent patients below 18 years (see section 4.2).
Slovenian: Asenapin ni indiciran za zdravljenje otrok in mladostnikov, mlajših od 18 let (glejte poglavje 4.2).
English: Given the primary effects of asenapine on the central nervous system (CNS) (see section 4.8), caution should be used when it is taken in combination with other centrally acting medicinal products.
Slovenian: Glede na to, da asenapin deluje predvsem na osrednje živčevje (CŽS) (glejte poglavje 4.8), je potrebna previdnost pri njegovi uporabi v kombinaciji z drugimi zdravili, ki delujejo na osrednje živčevje.
English: Following sublingual administration, asenapine is rapidly absorbed with peak plasma concentrations occurring within 0.5 to 1.5 hours.
Slovenian: Po podjezični uporabi se asenapin hitro absorbira in doseže največje plazemske koncentracije v 0,5 do 1,5 ure.
English: Overall mean (SD) weight gain at study endpoint was 3.5 (5.76) kg.
Slovenian: Celotno povprečno (SD) povečanje telesne mase v končni točki študije je znašalo 3,5 (5,76) kg.
English: Depending on the clinical response and tolerability in the individual patient, the dose can be increased to 10 mg twice daily.
Slovenian: Odvisno od kliničnega odziva in prenašanja zdravila pri posameznem bolniku se lahko odmerek poveča na 10 mg dvakrat na dan.
English: (EPS) which may include one or more of the following: abnormal movements of muscles,
Slovenian: (EPS) in v katero lahko sodi eden ali več od naslednjih simptomov: nenormalni gibi mišic,
English: Fertility No impairment of fertility has been observed in nonclinical studies (see section 5.3).
Slovenian: Plodnost V nekliničnih študijah niso opazili nikakršnega zmanjšanja plodnosti (glejte poglavje 5.3).
English: Asenapine may antagonise the effect of levodopa and dopamine agonists.
Slovenian: Asenapin lahko izniči učinke levodope in dopaminskih agonistov.
English: In most cases it was not clear if asenapine had been taken sublingually.
Slovenian: V večini primerov ni bilo jasno, ali je bolnik vzel zdravilo podjezično.
English: What Sycrest is and what it is used for What you need to know before you take Sycrest How to take Sycrest
Slovenian: Kaj je zdravilo Sycrest in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Sycrest Kako jemati zdravilo Sycrest Možni neželeni učinki
English: A population pharmacokinetic analysis indicated that smoking, which induces CYP1A2, has no effect on the clearance of asenapine.
Slovenian: Analiza populacijske farmakokinetike je pokazala, da kajenje, ki inducira izoencim CYP1A2, ne vpliva na očistek asenapina.
English: The sublingual tablets are provided in peelable blisters containing 10 tablets each.
Slovenian: Podjezične tablete so na voljo v pretisnih omotih, ki vsebujejo 10 tablet.
English: In clinical trials, the incidence of extrapyramidal symptoms in asenapine-treated patients was higher than placebo (15.4 % vs 11.0 %).
Slovenian: V kliničnih preskušanjih je bila incidenca ekstrapiramidnih simptomov pri bolnikih, zdravljenih z asenapinom, večja kakor pri placebu (15,4 % v primerjavi z 11,0 %).
English: N.V. Organon Kloosterstraat 6
Slovenian: Organon Kloosterstraat 6
English: Clinical efficacy in bipolar I disorder
Slovenian: Klinična učinkovitost pri bipolarni motnji I
English: In dogs high oral doses resulted in hepatotoxicity that was not observed after chronic intravenous administration.
Slovenian: Pri psih so veliki peroralni odmerki povzročili hepatotoksičnost, ki pa je niso opazili po kronični intravenski uporabi.
English: Injury, poisoning and procedural complications
Slovenian: Poškodbe in zastrupitve in zapleti pri posegih padci*
English: Additional clinical signs may include myoglobinuria (rhabdomyolysis) and acute renal failure.
Slovenian: Med dodatne klinične znake lahko sodijo mioglobinurija (rabdomioliza) in akutna ledvična odpoved.
English: Sycrest activity is primarily due to the parent compound.
Slovenian: Delovanje zdravila Sycrest je predvsem posledica delovanja same matične spojine.
English: NL- 5349 AB Oss The Netherlands
Slovenian: NL- 5349 AB Oss Nizozemska
English: Assessment of the relationship between atypical antipsychotic use and glucose abnormalities is complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia or bipolar disorder and the increasing incidence of diabetes mellitus in the general population.
Slovenian: Ocenjevanje povezanosti med uporabo atipičnih antipsihotikov in nastankom motenj uravnavanja glukoze je težavno zaradi možnosti povečanega osnovnega tveganja za nastanek sladkorne bolezni pri bolnikih s shizofrenijo ali bipolarno motnjo in naraščajoče incidence sladkorne bolezni v splošni populaciji.
English: In case of severe extrapyramidal symptoms, anticholinergic medicines should be administered.
Slovenian: V primeru hudih ekstrapiramidnih simptomov je treba bolniku dati antiholinergična zdravila.
English: Asenapine is a high clearance compound, with a clearance after intravenous administration of 52 L/h.
Slovenian: Asenapin je spojina z velikim očistkom, saj znaša njegov očistek po intravenski uporabi 52 l/h.
English: You should avoid drinking alcohol when taking this medicine.
Slovenian: Med jemanjem tega zdravila se izogibajte pitju alkohola.
English: This will usually pass on its own but if it does not, tell your doctor.
Slovenian: Omedlevica pa običajno mine sama - če ne mine, se posvetujte z zdravnikom.
English: Sycrest sublingual tablets should not be chewed or swallowed.
Slovenian: Podjezičnih tablet zdravila Sycrest se ne sme žvečiti ali jih pogoltniti.
English: Manic episodes associated with bipolar I disorder is a condition with symptoms such as feeling “high”, having excessive amounts of energy, needing much less sleep than usual, talking very quickly with racing ideas and sometimes severe irritability.
Slovenian: Manične epizode, ki se pojavljajo pri bipolarni motnji I, pomenijo bolezen s simptomi, kot so občutek vznesenosti oz. vzhičenosti, čezmerna količina energije, dosti manjša potreba po spanju kot običajno, zelo hiter govor s prehitevajočimi mislimi in idejami in včasih huda razdražljivost.
English: Since Sycrest works primarily in the brain, interference from other medicines(or alcohol) that work in the brain could occur due to an additive effect on brain function.
Slovenian: Ker zdravilo Sycrest deluje predvsem v možganih, lahko pride pri jemanju drugega zdravila (ali uživanju alkohola), ki tudi deluje v možganih, do motenj delovanja zdravila Sycrest zaradi seštevanja učinkov na delovanje možganov.
English: Based on a small pharmacokinetic study, paediatric patients appeared to be more sensitive to dystonia with initial dosing with asenapine when a gradual up-titration schedule was not followed (see section 5.2).
Slovenian: Majhna farmakokinetična študija je pokazala, da so pediatrični bolniki bolj nagnjeni k distoniji po začetnem odmerjanju asenapina, če ni upoštevana shema postopnega povečevanja odmerka (glejte poglavje 5.2).
English: Therefore, Sycrest should be co-administered cautiously with medicinal products that are both substrates and inhibitors for CYP2D6.
Slovenian: Zdravilo Sycrest je torej treba uporabljati previdno z zdravili, ki so tako substrati kot zaviralci CYP2D6.
English: Seek medical attention immediately if you have any of the following symptoms: - allergic reactions (These usually involve a combination of effects such as difficulty in breathing or swallowing, swollen face, lips, tongue or throat, skin rash, itching and increased heart rate.)
Slovenian: Takoj poiščite zdravniško pomoč, če imate katerega od naslednjih simptomov: - alergijske reakcije (Te ponavadi vključujejo kombinacijo učinkov, kot so težave pri dihanju ali požiranju, oteklost obraza, ustnic, jezika ali žrela, kožni izpuščaj, srbenje in povišan srčni utrip.)
English: Be sure to tell your doctor if you meet any of these conditions as he/she may want to adjust your dose or monitor you for a while.
Slovenian: Zdravniku morate povedati, če izpolnjujete katerega od zgornjih pogojev, ker vam bo morda moral prilagoditi odmerek zdravila ali vas nekaj časa bolj pozorno spremljati.
English: If you are taking this medicine and you become pregnant or you plan to get pregnant, ask your doctor as soon as possible whether you may continue taking Sycrest.
Slovenian: Če med jemanjem tega zdravila zanosite oziroma začnete načrtovati nosečnost, se čimprej posvetujte z zdravnikom, ali smete nadaljevati z jemanjem zdravila Sycrest.
English: Except for fluvoxamine, none of the interacting medicinal products resulted in clinically relevant alterations in asenapine pharmacokinetics.
Slovenian: Z izjemo fluvoksamina nobeno od zdravil z medsebojnimi delovanji ni povzročilo klinično pomembnih sprememb v farmakokinetiki asenapina.
English: Elderly patients with dementia-related psychosis Elderly patients with dementia-related psychosis treated with antipsychotic substances are at an increased risk of death.
Slovenian: Pri starejših bolnikih, ki imajo psihozo v okviru demence in se zdravijo z antipsihotiki, je tveganje za smrt povečano.
English: tongue, or jaw, slow or sustained muscle contractions, muscle spasms, tremor (shaking),
Slovenian: jezika ali čeljusti, upočasnjeno ali stalno krčenje mišic, mišični krči, tresenje (tremor),
English: Caution should be exercised when Sycrest is prescribed in patients with known cardiovascular disease or family history of QT prolongation, and in concomitant use with other medicinal products thought to prolong the QT interval.
Slovenian: Pri predpisovanju zdravila Sycrest bolnikom z znano srčno-žilno boleznijo ali podaljšanjem intervala QT v družinski anamnezi ter pri njegovi sočasni uporabi z drugimi zdravili, za katere menijo, da podaljšujejo interval QT, je potrebna previdnost.
English: In case of overdose you may feel sleepy or tired, or have abnormal body movements, problems with standing and walking, feel dizzy due to low blood pressure and feel agitated and confused.
Slovenian: V primeru prevelikega odmerjanja boste lahko postali zaspani ali utrujeni oziroma boste imeli nenormalne telesne gibe, težave pri stoji ali hoji, omotico zaradi nizkega krvnega tlaka in občutek vznemirjenosti ali zmedenosti.
English: Parkinson's disease and dementia with Lewy bodies Physicians should weigh the risks versus the benefits when prescribing Sycrest to patients with Parkinson's disease or dementia with Lewy Bodies (DLB) since both groups may be at increased risk of neuroleptic malignant syndrome as well as having an increased sensitivity to antipsychotics.
Slovenian: Parkinsonova bolezen in demenca z Lewyevimi telesci Zdravnik mora pri predpisovanju zdravila Sycrest bolnikom s Parkinsonovo boleznijo ali bolnikom, ki imajo demenco z Lewyevimi telesci (DLB), pretehtati tveganja in koristi uporabe antipsihotikov, ker imata lahko obe omenjeni skupini bolnikov večje tveganje za nastanek nevroleptičnega malignega sindroma, lahko pa sta tudi bolj občutljivi za antipsihotike.
English: The incidence of orthostatic hypotension in elderly subjects was 4.1 % compared to 0.3 % in the combined phase 2/3 trial population.
Slovenian: Incidenca ortostatske hipotenzije pri starostnikih je bila 4,1 %, v primerjavi z 0,3 % pri skupini bolnikov, ki so bili vključeni v kombinirano preskušanje druge in tretje faze.
English: At this dose foetal body weight decreased.
Slovenian: Pri tem odmerku je bila telesna masa plodov manjša.
English: Treatment with Sycrest is not advised in patients who are unable to comply with this method of administration, as the bioavailability of asenapine when swallowed is low (< 2 % with an oral tablet formulation).
Slovenian: Zdravljenje z zdravilom Sycrest ni priporočljivo pri bolnikih, ki ga ne morejo jemati na opisani način, ker je biološka uporabnost asenapina, če se ga pogoltne, majhna (< 2 % pri tabletah za peroralno uporabo).