FrancophonIA/ELRC3.0 huggingface dataset:
English: Side effects where the frequency cannot be estimated from the available data - bloodstream infection (sepsis) - changes of sugar in blood or serum (hypoglycaemia ), failure to grow, feeding intolerance - stimulation of central nervous system such as irritability, nervousness and restlessness; brain injury - deafness - regurgitation, increase in stomach aspirate - increase of urine flow, increase of certain urine components (sodium and calcium) - changes in blood tests (reduced levels of haemoglobin after prolonged treatment and reduced thyroid hormone at the start of treatment)
Croatian: - gluhoća - regurgitacija (vraćanje hrane iz želuca), povećanje učestalosti udisaja želučanog sadržaja, - pojačano mokrenje, povećanje određenih sastojaka mokraće (natrija i kalcija) - promjene krvnih nalaza (snižena razina hemoglobina nakon produljenog liječenja i snižen hormon štitne žlijezde na početku liječenja)
English: Alfasigma S.p.A.
Croatian: Chiesi Farmaceutici S.p.A.
English: • If your newborn has frequent regurgitation
Croatian: • Vaše novorođenče često ima vraćanje hrane iz želuca
English: - That Peyona is for the treatment of primary apnoea - That treatment with Peyona must be provided in a neonatal intensive care unit and initiated and supervised by a physician experienced in neonatal intensive care - Details of the loading and maintenance dosages and that caffeine may accumulate in premature newborn infants because of its long half-life.
Croatian: Da liječenje lijekom Peyona mora biti provedeno u jedinicama neonatalne intenzivne skrbi i da ga mora započeti i nadzirati liječnik s iskustvom u neonatalnoj intenzivnoj skrbi.
English: As for all preterm infants, those treated with caffeine citrate should be carefully monitored for the development of necrotising enterocolitis (see section
Croatian: Što se tiče sve nedonoščadi, onu liječenu kofeincitratom potrebno je pažljivo nadzirati zbog mogućnosti razvoja nekrotizirajućeg enterokolitisa (vidjeti dio 4.4).
English: As bacterial overgrowth in the gut is associated with the development of necrotising enterocolitis, coadministration of caffeine citrate with medicinal products that suppress gastric acid secretion (antihistamine H2 receptor blockers or proton-pump inhibitors) may in theory increase the risk of necrotising enterocolitis (see section 4.4 and 4.8).
Croatian: (antihistaminski blokatori H2 receptora ili inhibitori protonske pumpe) može, teoretski, povisiti rizik od nekrotizirajućeg enterokolitisa (vidjeti dio 4.4 i 4.8).
English: Caffeine is rapidly distributed into the brain following caffeine citrate administration.
Croatian: Nakon primjene kofeincitrata, kofein se brzo raspodjeljuje u mozak.
English: Hepatic cytochrome P450 1A2 (CYP1A2) is involved in caffeine biotransformation in older individuals.
Croatian: U biotransformaciji kofeina u starijih osoba sudjeluje jetreni citokrom P450 1A2 (CYP1A2).
English: − infants whose mothers consume caffeine while providing breast milk for feeding.
Croatian: (vidjeti dio 4.5) − novorođenčad čije majke konzumiraju kofein u razdoblju dojenja djeteta.
English: If your newborn gets any side effects, talk to your baby's doctor.
Croatian: Ako se kod Vašeg djeteta jave bilo kakve nuspojave, potrebno je obavijestiti liječnika Vašeg djeteta.
English: In that case, infants received a second loading dose of 20 mg/kg caffeine citrate after treatment day 1 and before treatment day 8.
Croatian: U tom slučaju, dojenčad bi primila drugu udarnu dozu od 20 mg/kg kofeincitrata nakon
English: Apnoea of prematurity is a diagnosis of exclusion.
Croatian: Dijagnoza apneje nedonoščeta postavlja se isključivanjem drugih uzroka.
English: The known pharmacology and toxicology of caffeine and other methylxanthines predict the likely adverse reactions to caffeine citrate.
Croatian: Sažetak profila sigurnosti Vjerojatne nuspojave kofeincitrata mogu se predvidjeti na temelju poznavanja farmakologije i toksikologije kofeina i drugih metilksantina.
English: Each 3 ml ampoule contains 60 mg caffeine citrate (equivalent to 30 mg of caffeine base).
Croatian: Jedna ampula od 3 ml sadrži 60 mg kofeincitrata (što odgovara 30 mg kofeina).
English: Arrhythmia
Croatian: Apsorpcija
English: Tel: +386-1-43 00 901
Croatian: Chiesi Slovenija d.o.o. Tel: +386-1-43 00 901
English: Oral solution.
Croatian: Oralna otopina.
English: Chiesi Hungary Kft. Tel.:+36-1-429 1060
Croatian: Tel.:+36-1-429 1060
English: Tel: +421 259300060
Croatian: Chiesi Slovakia s.r.o. Tel: +421 259300060
English: Each ml contains 20 mg caffeine citrate (equivalent to 10 mg/ml of caffeine base).
Croatian: Jedan ml sadrži 20 mg kofeincitrata (što odgovara 10 mg/ml kofeina u obliku baze).
English: Each ml contains 20 mg caffeine citrate (equivalent to 10 mg caffeine).
Croatian: Jedan ml sadrži 20 mg kofeincitrata (što odgovara 10 mg kofeina).
English: − infants whose mothers may have ingested large quantities of caffeine prior to delivery (see section
Croatian: Savjetuje se izmjeriti početne koncentracije kofeina u: − novorođenčadi čije su majke unijele u organizam velike količine kofeina prije porođaja (vidjeti dio
English: Infants randomised to caffeine citrate received an intravenous loading dose of 20 mg/kg, followed by a daily maintenance dose of 5 mg/kg.
Croatian: Nedonoščad randomizirana u skupinu koja je primala kofeincitrat dobila je intravenski udarnu dozu od 20 mg/kg,
English: The diagnosis of apnoea of prematurity may need to be reconsidered if patients do not respond adequately to a second loading dose or maintenance dose of 10 mg/kg/day (see section 4.4).
Croatian: možda će biti potrebno ponovno razmotriti dijagnozu apneje u nedonoščadi (vidjeti dio 4.4).
English: Type I clear glass 1 ml ampoule Type I clear glass 3 ml ampoule Pack size of 10 ampoules.
Croatian: I od 1 ml Ampula od prozirnog stakla tipa
English: - That the medicinal product should be used immediately after opening the ampoule and unused portions left in the ampoule should be discarded - That baseline plasma levels may need measuring because of an increased risk of toxicity if o The neonate has been previously treated with theophylline o The mother has been consuming large amounts of caffeine prior to delivery or breast feeding - That caffeine and theophylline should not be used concurrently - That if caffeine and doxapram are used concurrently, the patient should be closely monitored - That additional plasma caffeine monitoring and dosage adjustment may be necessary in at risk situations such as preterm infants: o With cholestatic hepatitis o With significant renal impairment o With seizure disorders o With cardiac disease o less than 28 weeks gestational age and/or body weight <1000g particularly when receiving parenteral nutrition o with co-administration of medicinal products known to interfere with caffeine metabolism - That cardiac disorders (including arrhythmias) may arise in newborn infants with pre-existing cardiac disease - That all suspected adverse reactions should be reported in accordance with national reporting requirements - In particular, if convulsions, seizures, necrotising enterocolitis, symptoms and signs of caffeine withdrawal, medically abnormal decrease in infant weight gain or interactions with other medicines are suspected as being associated with the use of caffeine citrate, these should be reported to <insert local name and address of Chiesi Farmaceutici S.p.A.>
Croatian: o s kolestatskim hepatitisom o sa značajnim oštećenjem funkcije bubrega o s konvulzivnim poremećajem o sa srčanom bolešću o s manje od 28 tjedana gestacijske dobi i/ili tjelesne težine <1000 g osobito kad primaju parenteralnu prehranu o kad se istovremeno primjenjuju lijekovi za koje se zna da utječu na metabolizam kofeina
English: Each 1 ml ampoule contains 20 mg of caffeine citrate (equivalent to 10 mg of caffeine base).
Croatian: Jedna ampula od 1 ml sadrži 20 mg kofeincitrata (što odgovara 10 mg kofeina).
English: • If your newborn has a reduced weight gain or food intake • If you (the mother) consumed caffeine prior to delivery
Croatian: • Vaše novorođenče sporo dobiva na tjelesnoj težini ili slabije jede
English: Ampoules containing discoloured solution or visible particulate matter should be discarded.
Croatian: Ampule s otopinom koja je promijenila boju ili sadrži čestice bacite.
English: Irritability, jitteriness, restlessness, brain injury
Croatian: Poremećaji živčanog sustava konvulzije manje često razdražljivost, nervoza, nemir oštećenje mozga nepoznato
English: - If your newborn gets any side effects, talk to your baby's doctor.
Croatian: - Ako u Vašeg novoeođenčeta primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika
English: LIST OF EXCIPIENTS
Croatian: Put primjene
English: Inter-conversion between caffeine and theophylline occurs in preterm newborn infants.
Croatian: U nedonoščadi dolazi do interkonverzije kofeina i teofilina.
English: Chiesi Pharmaceuticals B.V. Tel: +31 88 501 64 00
Croatian: Tel: +31 88 501 64 00
English: Read the package leaflet before use Intravenous use
Croatian: Prije uporabe pročitati Uputu o lijeku.
English: Where clinically indicated, caffeine plasma levels should be monitored.
Croatian: Potrebno je pratiti razine kofeina u plazmi, kad je to klinički indicirano.
English: Peyona should be inspected visually for particulate matter and discoloration prior to administration.
Croatian: Prije primjene, lijek Peyona treba vizualno pregledati na prisutnost čestica ili promjenu boje.
English: Reporting of side effects
Croatian: Učestalost primjene
English: Oclaticinib
Croatian: Oclacitinib
English: This summary was last updated in July 2013.
Croatian: Sažetak je posljednji put obnovljen u srpnju 2013.
English: The success rates in the second study were similar.
Croatian: Stope uspjeha u drugom ispitivanju bile su slične.
English: Treatment may then be continued at the same dose given once a day.
Croatian: Liječenje se može nastaviti s istom dozom koja se uzima jednom dnevno.
English: Hands should be washed after handling the tablets.
Croatian: Potrebno je oprati ruke nakon primjene tableta.
English: Other information about Apoquel:
Croatian: Druge informacije o lijeku Apoquel:
English: Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks.
Croatian: Liječenje se mora započeti s dozom od 0,4 - 0,6 mg po kilogramu tjelesne mase dva puta dnevno tijekom dva tjedna.
English: One study involved 220 dogs and the second involved 299 dogs.
Croatian: Jedno je ispitivanje obuhvatilo 220 pasa, a drugo 299 pasa.
English: Apoquel tablets are available in three different strengths (3.5 mg, 5.4 mg and 16 mg) to cover a range of dog weights.
Croatian: Tablete Apoquel dostupne su u tri različite jačine (3,5 mg, 5,4 mg i 16 mg) kako bi se pokrio cijeli raspon tjelesnih težina pasa.
English: The measure of effectiveness in the studies was based on the assessment by the dog owner of the severity of the pruritus and improvements in the dog's behaviour using a standard scale.
Croatian: Mjera djelotvornosti u ovim ispitivanjima temelji se na procijeni vlasnika psa o ozbiljnosti pruritusa i poboljšanju ponašanja psa na temelju standardne ljestvice.
English: The Committee for Medicinal Products for Veterinary Use (CVMP) concluded that the benefits of Apoquel exceed the risks for the approved indications and recommended that Apoquel be given a marketing authorisation.
Croatian: Odbor za veterinarsko-medicinske proizvode (CVMP) zaključio je da koristi lijeka Apoquel nadmašuju rizike za odobrene indikacije, te je preporučio izdavanje odobrenja za stavljanje u promet lijeka Apoquel.
English: The active substance in Apoquel, oclacitinib, is an immunomodulator (a medicine that changes the activity of the immune system) that works by blocking the action of enzymes known as Janus kinases.
Croatian: Djelatna tvar u lijeku Apoquel, oclacitinib, je imunomodulator (lijek koji mijenja aktivnost imunološkog sustava) koji djeluje inhibirajući djelovanje enzima poznatog pod nazivom Janus kinaza.
English: By blocking the enzymes, Apoquel reduces the inflammation and itchiness associated with the disease.
Croatian: Inhibirajući enzime, Apoquel smanjuje upalu i svrbež povezane s bolešću.
English: If you want more information on the basis of the CVMP recommendations, read the scientific discussion (also part of the EPAR).
Croatian: Ako želite više informacija na temelju preporuka Odbora za veterinarsko-medicinske proizvode (CVMP), pročitajte znanstvenu raspravu (ona je dio Europskoga javnog izvješća o procjeni veterinarsko-medicinskog proizvoda (EPAR)).
English: In both, Apoquel was compared with placebo.
Croatian: U oba je ispitivanja Apoquel uspoređen s placebom.
English: Apoquel is a veterinary medicine that contains the active substance oclaticinib.
Croatian: Apoquel je veterinarsko-medicinski proizvod koji sadrži djelatnu tvar oclacitinib.
English: The most common side effects were diarrhoea, vomiting and loss of appetite in decreasing order of frequency.
Croatian: Najčešće nuspojave su proljev, povraćanje i gubitak apetita opadajućim redoslijedom učestalosti.
English: What is Apoquel?
Croatian: Što je Apoquel?
English: It is also used in dogs to treat atopic dermatitis.
Croatian: Primjenjuje se i u pasa za liječenje atopijskog dermatitisa.
English: The atopic dermatitis indication was also investigated in two field studies.
Croatian: Indikacija atopijskog dermatitisa također je ispitana u dva terenska ispitivanja.
English: In one, Apoquel was compared with prednisolone (an immunosuppressant) in 220 dogs, and in the other Apoquel was compared with placebo (dummy treatment) in 436 dogs.
Croatian: U jednom je Apoquel uspoređen s prednizolonom (imunosuprezivom) u 220 pasa, a u drugom je ispitivanju Apoquel uspoređen s placebom (liječenjem bez djelatne tvari) u 436 pasa.
English: What is the risk associated with Apoquel?
Croatian: Koji su rizici povezani s lijekom Apoquel?
English: These enzymes play an important role in the processes of inflammation and itchiness including those involved in allergic dermatitis and atopic dermatitis in dogs.
Croatian: Ovi enzimi imaju značajnu ulogu u upalnim procesima i svrbeži, uključujući i alergijski dermatitis i atopijski dermatitis u pasa.
English: Why has Apoquel been approved?
Croatian: Zašto je Apoquel odobren?
English: For atopic dermatitis the treatment success rate for Apoquel-treated dogs in the first study was 66% compared with 4% in placebo-treated dogs using pruritus assessment; the results for CADESI scores were 49% and 4% respectively.
Croatian: U slučaju atopijskog dermatitisa, stopa uspjeha za liječenje pasa liječenih lijekom Apoquel u prvom ispitivanju iznosila je 66% u usporedbi sa 4% u pasa liječenih placebom uz primjenu procjene pruritusa; rezultati prema indeksu CADESI iznosili su 49%, odnosno 4%.
English: Apoquel is used in dogs to treat pruritus (itching) associated with allergic dermatitis (inflammation of the skin).
Croatian: Apoquel se koristi u pasa za liječenje pruritusa (svrbeža) povezanog s alergijskim dermatitisom (upalom kože).
English: In the pruritus study comparing Apoquel with prednisolone, both medicines were shown to be effective, with a successful response seen in 68% of dogs treated with Apoquel, and 76% of those treated with prednisolone.
Croatian: U ispitivanju pruritusa, u kojem je Apoquel uspoređen s prednizolonom, oba lijeka pokazala su se učinkovitima, s uspješnim odgovorom u 68% pasa liječenih lijekom Apoquel, te 76% liječenih prednizolonom.
English: Studies in atopic dermatitis also used assessment of skin lesions on a score known as the canine atopic dermatitis extent and severity index (CADESI).
Croatian: Ispitivanja atopijskog dermatitisa koristila su i procjenu lezija kože na ljestvici poznatoj pod nazivom indeks opsega i ozbiljnosti psećeg dermatitis (CADESI).
English: In case of accidental ingestion, medical advice should be sought immediately and the package leaflet or the label shown to the doctor.
Croatian: U slučaju da se nehotice proguta, odmah potražite pomoć liječnika i pokažite mu uputu o VMP-u ili etiketu.
English: When compared with placebo, the success rate was 67% for Apoquel-treated dogs and 29% for placebo-treated dogs.
Croatian: U usporedbi s placebom, stopa uspješnosti iznosila je 67% u slučaju pasa liječenih lijekom Apoquel i 29% u slučaju pasa liječenih placebom.
English: The action of Apoquel in pruritus associated with allergic dermatitis was studied in two field studies.
Croatian: Djelovanje lijeka Apoquel u slučaju pruritusa povezanog s alergijskim dermatitisom ispitano je u dva terenska ispitivanja.
English: What benefit has Apoquel shown during the studies?
Croatian: Koje koristi lijeka Apoquel su dokazane u ispitivanjima?
English: What is Apoquel used for?
Croatian: Za što se Apoquel koristi?
English: For a full list of all side-effects reported with Apoquel, see the package leaflet.
Croatian: Potpuni popis svih nuspojava koje su zabilježene s lijekom Apoquel pročitajte u uputi o VMP-u.
English: Apoquel should not be given to dogs less than one year of age or weighing less than 3 kg. Apoquel should not be given to dogs with signs of immune suppression or progressive cancer as Apoquel has not been studied in such cases.
Croatian: Apoquel se ne smije primjenjivati u pasa sa znakovima imunološke supresije ili progresivnog raka s obzirom da lijek Apoquel nije ispitan u tim slučajevima.
English: For the appropriate strength of tablets and number of tablets to be given, see the dosage table in the package leaflet.
Croatian: Primjerena jačina i količina tableta navedena je u tablici doziranja u uputi o VMP-u.
English: How does Apoquel work?
Croatian: Kako djeluje Apoquel?
English: The European Commission granted a marketing authorisation valid throughout the European Union, for Apoquel on 12/09/2013.
Croatian: Europska komisija izdaje odobrenje za stavljanje u promet koje za lijek Apoquel vrijedi na prostoru Europske unije od 12.09.2013. Informacije o tome je li za ovaj proizvod potreban veterinarski recept možete naći na etiketi/vanjskom dijelu pakiranja.
English: How has Apoquel been studied?
Croatian: Kako se Apoquel ispitivao?
English: Harmful for those suffering from alcoholism.
Croatian: Štetan je za one koji pate od alkoholizma.
English: • if you are pregnant
Croatian: • ako ste trudni.
English: A single injection is enough.
Croatian: Jedna injekcija je dovoljna.
English: I) which remains in your body will naturally lose its radioactivity.
Croatian: I) koji preostane u Vašem tijelu prirodno će izgubiti svoju radioaktivnost.
English: • You will need to continue to do this for 3 days, until the radioactivity is no longer in your body.
Croatian: • Morat ćete to raditi 3 dana, dok radioaktivnost više ne bude prisutna u Vašem tijelu.
English: It will be passed out of the body in a few days without need for you to take special precautions.
Croatian: Bit će izlučena iz tijela za nekoliko dana bez potrebe da poduzimate posebne mjere opreza.
English: DaTSCAN will always be used in a hospital or a similar place.
Croatian: DaTSCAN će se uvijek koristiti u bolnici ili sličnom mjestu.
English: I) are listed in the Table below.
Croatian: I) prikazane su u tablici dolje.
English: They should tell you anything you need to do for the safe use of this medicine.
Croatian: Oni bi Vam trebali reći sve što trebate napraviti za sigurnu primjenu ovog lijeka.
English: I) which is used to help identify (diagnose) conditions in the brain.
Croatian: I) koja se koristi kako bi pomogla identificirati (dijagnosticirati) stanja u mozgu.
English: Each dose contains up to 197 mg alcohol.
Croatian: Svaka doza sadrži do 197 mg alkohola.
English: The following information is intended for the specialist only:
Croatian: Sljedeće informacije namijenjene su samo specijalistima:
English: It collects in a small area of your brain.
Croatian: Zatim se nakuplja u malom području Vašeg mozga.
English: Common: may affect up to 1 in 10 people - Headache
Croatian: Često: mogu se pojaviti u do 1 od 10 osoba - Glavobolja
English: Do not exceed 185 MBq and do not use when the activity is below 110 MBq.
Croatian: Ne prelazite 185 MBq i ne koristite kad je aktivnost ispod 110 MBq.
English: There is no experience in types of tremor other than essential tremor.
Croatian: Nema iskustva s drugim vrstama tremora, osim esencijalnog tremora.
English: Ioflupane is a cocaine analogue.
Croatian: Ioflupan je analog kokaina.
English: Read all of this leaflet carefully before you start using this medicine because it contains important information for you.
Croatian: Pažljivo pročitajte cijelu uputu prije nego počnete primjenjivati ovaj lijek, jer sadrži Vama važne podatke.
English: Prior to administration appropriate resuscitation equipment should be available.
Croatian: Prije primjene, mora biti dostupna odgovarajuća oprema za oživljavanje.
English: Very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥ 1/10,000 to <1/1,000), very rare (<1/10,000) and not known (cannot be estimated from the available data).
Croatian: Vrlo često (≥1/10), često (≥1/100 do <1/10), manje često (≥1/1000 do <1/100), rijetko (≥1/10 000 do <1/1000), vrlo rijetko (<1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: This scan will show exactly where the radioactivity is inside the organ and the body.
Croatian: Taj sken će prikazati gdje se točno nalazi radioaktivnost unutar organa i tijela.
English: Some medicines may reduce the quality of the picture obtained.
Croatian: Neki lijekovi mogu umanjiti kvalitetu dobivene slike.
English: Changes in this area of the brain occur in:
Croatian: Promjene u tom području mozga događaju se kod:
English: • Because it contains a small amount of radioactivity it can be detected from outside the body using special cameras.
Croatian: • Zbog toga što sadrži malu količinu radioaktivnosti može se detektirati izvan tijela, uporabom posebnih kamera.
English: There are strict laws on the use, handling and disposal of radioactivity.
Croatian: Postoje strogi zakoni o uporabi, rukovanju i zbrinjavanju radioaktivnosti.
English: You will need to be careful with the water (urine) that you pass - your doctor will tell you what to do.
Croatian: Morate biti oprezni s tekućinom (mokraćom) koju izmokravate - liječnik će Vam objasniti što napraviti.
English: This is about the same as 5 ml beer, or 2 ml wine.
Croatian: To je otprilike jednako kao 5 ml piva ili 2 ml vina.
English: About 30% of the whole brain activity is attributed to striatal uptake.
Croatian: Oko 30% cijele aktivnosti mozga pripisuje se striatalnom unosu.
English: The amount of radioactivity in the body from DaTSCAN is very small.
Croatian: Količina radioaktivnosti u tijelu od DaTSCAN-a jako je mala.
English: • if you are allergic to ioflupane or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični na ioflupan ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Not known: Feeling hot
Croatian: Nepoznato: Osjećaj vrućine
English: Bq/mmol) at reference time.
Croatian: Bq/mmola) u referentnom vremenu.
English: It belongs to a group of medicines called “radiopharmaceuticals”, which contain a small amount of radioactivity.
Croatian: Pripada skupini lijekova zvanih "radiofarmaceutici", koji sadrže malu količinu radioaktivnosti.
English: A scan will give your doctor information about any changes in this area of your brain.
Croatian: Slika (sken) će liječniku dati informacije o svim promjenama u tom dijelu Vašeg mozga.
English: DaTSCAN contains alcohol (ethanol) 5 % by volume.
Croatian: DaTSCAN sadrži alkohol (etanol), 5% volumena.
English: 5612 AP, Eindhoven The Netherlands
Croatian: 5612 AP, Eindhoven Nizozemska
English: The above data are valid in normal pharmacokinetic behaviour.
Croatian: Navedeni podaci vrijede za normalno farmakokinetičko ponašanje.
English: For high resolution collimators the radius of rotation should be consistent and set as small as possible (typically 11-15cm).
Croatian: Za kolimatore visoke rezolucije promjer rotacije treba biti konzistentan i postavljen što manje (uobičajeno 11-15 cm).
English: The doctor may ask you to stop taking them for a short time before you receive DaTSCAN.
Croatian: Liječnik od Vas može zatražiti da ih nakratko prestanete koristiti prije nego primite DaTSCAN.