FrancophonIA/ELRC3.0 huggingface dataset:
English: Midazolam 7.5 mg Single Dose (maraviroc 300 mg BID)
Slovenian: SEDATIVI Benzodiazepini Midazolam 7,5 mg enkraten odmerek (maravirok 300 mg dvakrat na dan)
English:  fits (seizures)  feeling dizzy, faint or light headed when standing up  kidney failure, protein in the urine
Slovenian: • občutek omotice, omedlevice ali vrtoglavice pri vstajanju,
English: Raltegravir 400 mg BID (maraviroc 300 mg BID)
Slovenian: Raltegravir 400 mg dvakrat na dan (marivarok 300 mg dvakrat na dan)
English: Effects on active substance levels Geometric mean change if not stated otherwise
Slovenian: Če ni navedeno drugače, gre za spremembo geometrijskih sredin
English: CELSENTRI 25 mg film-coated tablets maraviroc
Slovenian: IME ZDRAVILA CELSENTRI 25 mg filmsko obložene tablete maravirok
English: Race (White/Black/Other) Mean Baseline HIV-1 RNA (log10 copies/mL) Median Baseline CD4+ Cell Count (cells/mm3) (range, cells/mm3)
Slovenian: Mediano izhodiščno število celic CD4+ (celic/mm3) (razpon, celic/mm3)
English: CELSENTRI 300 mg twice daily and pegylated interferon can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z pegiliranim interferonom brez prilagoditve odmerka.
English: CELSENTRI 300 mg twice daily and levonorgestrel can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z levonorgestrelom brez prilagoditve odmerka.
English: Studies in Treatment-Experienced Adult Patients Infected with CCR5-tropic Virus
Slovenian: Študije pri predhodno že zdravljenih odraslih bolnikih okuženih z CCR5-tropnim virusom
English: CELSENTRI 300 mg twice daily and raltegravir can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z raltegravirjem brez prilagoditve odmerka.
English: Lopinavir/ritonavir concentrations not measured, no effect is expected.
Slovenian: Koncentraciji lopinavirja/ritonavirja nista bili merjeni, učinki niso pričakovani.
English: Ritonavir Cmax: ↔ 1.02 Ritonavir C12: ↓ 0.74
Slovenian: Ritonavir AUC12: ↔ 0,93 Ritonavir Cmax: ↔ 1,02
English: CELSENTRI 300 mg twice daily and methadone can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z metadonom brez prilagoditve odmerka.
English: GlaxoSmithKline (Cyprus) Ltd
Slovenian: România GlaxoSmithKline (GSK) S.R.L.
English: CELSENTRI dose should be decreased to 150 mg twice daily when co-administered with ketoconazole.
Slovenian: Med sočasno uporabo zdravila CELSENTRI s ketokonazolom je treba odmerek zdravila CELSENTRI zmanjšati na 150 mg dvakrat na dan.
English: Atazanavir concentrations not measured, no effect is expected.
Slovenian: Koncentracija atanazavirja ni bila merjena, učinki niso pričakovani.
English: Combination with two inducers has not been studied.
Slovenian: Rifampicin + efavirenz Kombinacija obeh induktorjev ni raziskana.
English: Maraviroc AUC12 ↑ 3.95
Slovenian: Maravirok AUC12: ↑ 3,95
English: Efavirenz, saquinavir/ritonavir concentrations not measured, no effect expected.
Slovenian: Koncentracije efavirenza in sakvinavirja/ritonavirja niso bile merjene, učinki niso pričakovani.
English: CELSENTRI dose should be increased to 600 mg twice daily when coadministered with carbamazepine, phenobarbital or phenytoin in the absence of a potent CYP3A4 inhibitor.
Slovenian: Če je zdravilo CELSENTRI uporabljeno sočasno s karbamazepinom, fenobarbitalom ali fenitoinom, brez močnega zaviralca CYP3A4, je treba odmerek zdravila CELSENTRI povečati na 600 mg dvakrat na dan.
English: Celsentri 300 mg film-coated tablets maraviroc
Slovenian: IME ZDRAVILA CELSENTRI 300 mg filmsko obložene tablete maravirok
English: LIST OF EXCIPIENTS PHARMACEUTICAL FORM AND CONTENTS
Slovenian: FARMACEVTSKA OBLIKA peroralna raztopina
English: Some people taking combination therapy for HIV develop a condition called osteonecrosis.
Slovenian: Bolečine v sklepih, togost sklepov in težave s kostmi Pri nekaterih bolnikih, ki imajo kombinirano zdravljenje okužbe z virusom HIV, se lahko pojavi stanje, imenovano osteonekroza.
English: 600 mg twice daily
Slovenian: 600 mg dvakrat na dan zdravilo
English: Celsentri 150 mg film-coated tablets maraviroc
Slovenian: IME ZDRAVILA CELSENTRI 150 mg filmsko obložene tablete maravirok
English: CELSENTRI 300 mg twice daily and midazolam can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z midazolamom brez prilagoditve odmerka.
English: CELSENTRI dose should be decreased to 150 mg twice daily when co-administered with itraconazole.
Slovenian: Med sočasno uporabo zdravila CELSENTRI z itrakonazolom je treba odmerek zdravila CELSENTRI zmanjšati na 150 mg dvakrat na dan.
English: CELSENTRI dose should be decreased to 150 mg twice daily when co-administered with clarithromycin and telithromycin.
Slovenian: Med sočasno uporabo zdravila CELSENTRI s klaritromicinom oz. telitromicinom je treba njegov odmerek zmanjšati na 150 mg dvakrat na dan.
English: CELSENTRI 300 mg twice daily and buprenorphine can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z buprenorfinom brez prilagoditve odmerka.
English: Saquinavir/ritonavir concentrations not measured, no effect is expected.
Slovenian: Koncentraciji sakvinavirja/ritonavirja nista bili merjeni, učinki niso pričakovani.
English: copies per mL), mean CD4+ cell count was 551 cells/mm3 (range 1 to 1654 cells/mm3) and mean CD4+ % was 21% (range 0% to 42%).
Slovenian: 3) in povprečni odstotek CD4+ je bil 21 % (razpon: od 0 do 42 %).
English: Efavirenz, lopinavir/ritonavir concentrations not measured, no effect expected.
Slovenian: Koncentracije efavirenza in lopinavirja/ritonavirja niso bile merjene, učinki niso pričakovani.
English: CELSENTRI 300 mg twice daily and ribavirin can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno z ribavirinom brez prilagoditve odmerka.
English: NNRTI + PI Efavirenz 600 mg QD + lopinavir/ritonavir 400mg/100 mg BID (maraviroc 300 mg BID)
Slovenian: Nenukleozidni zaviralci reverzne transkriptaze (NNRTI) + zaviralci proteaz (PI) Efavirenz 600 mg enkrat na dan + lopinavir/ritonavir
English: CELSENTRI contains a medicine called maraviroc.
Slovenian: Zdravilo CELSENTRI vsebuje učinkovino maravirok.
English: CELSENTRI 300 mg twice daily and statins can be co-administered without dose adjustment.
Slovenian: Zdravilo CELSENTRI 300 mg dvakrat na dan je mogoče uporabljati sočasno s statini brez prilagoditve odmerka.
English: Concomitant Medications
Slovenian: ZDRAVILA
English: Atazanavir/ritonavir concentrations not measured, no effect is expected.
Slovenian: Koncentraciji atanazavirja/ritonavirja nista bili merjeni, učinki niso pričakovani.
English:  feeling dizzy, faint or light headed when standing up  kidney failure, protein in the urine
Slovenian: • odpoved ledvic, proteini v urinu,
English: NAME OF THE MARKETING AUTHORISATION HOLDER
Slovenian: Imetnik dovoljenja za promet z zdravilom in izdelovalec
English: Carton for bottle containing 20 mg/ml maraviroc oral solution
Slovenian: PODATKI NA ZUNANJI OVOJNINI Škatla za plastenko, ki vsebuje peroralno raztopino z 20 mg/ml maraviroka
English: CELSENTRI dose should be increased to 600 mg twice daily when co-administered with efavirenz in the absence of a potent CYP3A4 inhibitor.
Slovenian: Če je zdravilo CELSENTRI uporabljeno sočasno z efavirenzom, brez drugega močnega zaviralca CYP3A4, je treba njegov odmerek povečati na 600 mg dvakrat na dan.
English: CELSENTRI dose should be increased to 600 mg twice daily when co-administered with rifampicin in the absence of a potent CYP3A4 inhibitor.
Slovenian: Če je zdravilo CELSENTRI uporabljeno sočasno z rifampicinom, brez močnega zaviralca CYP3A4, je treba njegov odmerek povečati na 600 mg dvakrat na dan.
English: CELSENTRI 20 mg/ml oral solution
Slovenian: CELSENTRI 20 mg/ml peroralna raztopina 2.
English: Maraviroc AUC12 ↑ 3.57
Slovenian: Maravirok AUC12: ↑ 3,57
English: Blood and lymphatic system disorders Absolute neutrophil count
Slovenian: Bolezni krvi in limfatičnega sistema anemija pogosti pancitopenija, granulocitopenija redki
English: Carton for blister pack containing 300 mg maraviroc film-coated tablets
Slovenian: PODATKI NA ZUNANJI OVOJNINI Škatla za pretisne omote s 300 mg filmsko obloženimi tabletami
English: Carton for blister pack containing 150 mg maraviroc film-coated tablets
Slovenian: PODATKI NA ZUNANJI OVOJNINI Škatla za pretisne omote s 150 mg filmsko obloženimi tabletami
English: Do not open them.
Slovenian: Ne odpirajte jih.
English: Number of subjects at risk Month
Slovenian: Število oseb, pri katerih obstaja tveganje Meseci
English: Date of first authorisation: 21 March 2014 Date of latest renewal: 28 March 2019
Slovenian: Datum prve odobritve: 21. marec 2014 Datum zadnjega podaljšanja: 28. marec 2019
English: In case of such combination, INR values should be monitored.
Slovenian: Pri takšni kombinaciji, je treba spremljati vrednosti INR.
English: The median time to first dose reduction was 43 days, and to first dose interruption was 33 days.
Slovenian: Mediani čas do prvega zmanjšanja odmerka je bil 43 dni, do prve prekinitve odmerjanja pa 33 dni.
English: Dose reductions are recommended for events that, if persistent, could become serious or intolerable.
Slovenian: Zmanjšanje odmerka se priporoča za dogodke, ki bi lahko, če bi trajali dlje časa, postali resni ali nevzdržni.
English: The clinical significance of these potential interactions is unknown.
Slovenian: Klinični pomen te možne interakcije ni znan.
English: Evaluations in juvenile rats (comparable to a <2 year old pediatric population) have not been performed.
Slovenian: Ocenitve mladih podgan (primerljivo z < 2-letno pediatrično populacijo) niso izvedli.
English: Tell your doctor straight away if you notice any of the following side effects - you may need urgent medical treatment:
Slovenian: Zdravniku takoj povejte, če opazite katerega od naslednjih neželenih učinkov - morda potrebujete nujno zdravljenje:
English: No specific dosing recommendations can be made.
Slovenian: Posebnih priporočil za odmerjanje ni mogoče dati.
English: It may help shrink tumours associated with this type of cancer.
Slovenian: Pomaga lahko skrčiti tumorje, povezane s to vrsto raka.
English: Frequencies are based on all grades and defined as: very common (≥1/10), common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100), not known (cannot be estimated from the available data).
Slovenian: Pogostnosti temeljijo na vseh stopnjah in so opredeljene kot: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100); neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: The clinical relevance of the observed neoplastic lesions in rats is uncertain, but likely to be low.
Slovenian: Klinična pomembnost opazovanih neoplastičnih lezij pri podganah je negotova, a po vsej verjetnosti nizka.
English: Metabolic clinical laboratory parameters should be monitored at least weekly or as deemed clinically appropriate to assess any possible changing trends.
Slovenian: Presnovne klinične laboratorijske parametre je treba spremljati vsaj tedensko ali kot je klinično ustrezno, da se ocenijo možne spremembe v trendih.
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.
Slovenian: O neželenih učinkih lahko poročate tudi neposredno na nacionalni center za poročanje, ki je naveden v prilogi V. S tem, ko poročate o neželenih učinkih, lahko prispevate k zagotovitvi več informacij o varnosti tega zdravila.
English: Next generation sequencing of RET exons 10, 11, and 13-16 will be performed, which covers the vast majority of known RET mutations.
Slovenian: Opravljena bo naslednja generacija določanja zaporedja RET za eksone 10, 11 in 13-16, ki bo krila veliko večino znanih mutacij RET.
English: (1/55)c a Response = CR + PR b Disease Control Rate = SD+ ORR c Includes patients who were evaluable for response
Slovenian: (1/55)c a Odziv = CR + PR b Stopnja nadzora bolezni = SD+ ORR c Vključuje bolnike, pri katerih je bilo mogoče oceniti odziv
English: The capsules should be swallowed whole and not opened.
Slovenian: Kapsule je treba pogoltniti cele brez odpiranja.
English: The effects of COMETRIQ in people younger than 18 years old are not known.
Slovenian: Učinki zdravila COMETRIQ pri ljudeh, mlajših od 18 let, niso znani.
English: You should continue to take this medicine until your doctor decides to stop your treatment.
Slovenian: To zdravilo jemljite, dokler se zdravnik ne odloči, da se boste prenehali zdraviti.
English: RET mutation status
Slovenian: Status mutacije RET
English: To remove the capsules for your dose:
Slovenian: Odstranjevanje kapsul za vaš odmerek:
English: It is not known whether cabozantinib and/or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se kabozantinib in/ali njegovi presnovki izločajo v človeško mleko.
English: As most events can occur early in the course of treatment, the physician should evaluate the patient closely during the first eight weeks of treatment to determine if dose modifications are warranted.
Slovenian: Ker se lahko večina dogodkov pojavi zgodaj v teku zdravljenja, mora zdravnik bolnika v prvih osmih tednih zdravljenja skrbno oceniti, da presodi, ali je treba odmerek prilagoditi.
English: The secondary objectives were to compare overall response rate (ORR) and overall survival (OS).
Slovenian: Sekundarni opazovani točki sta bili primerjava celokupne stopnje odziva (ORR, overall response rate) in celokupnega preživetja (OS, overall survival).
English: Take the next dose at the normal time.
Slovenian: Naslednji odmerek vzemite ob običajnem času.
English: Do not take COMETRIQ - if you are allergic to cabozantinib or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila COMETRIQ - če ste alergični na kabozantinib ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: • Loss of taste
Slovenian: • izguba okusa
English: Record date of first dose.
Slovenian: Zabeležite datum prvega odmerka.
English: To help you remember your doses, write the date when you took your first dose in the space next to the capsules.
Slovenian: Da si boste odmerke lažje zapomnili, zapišite datum, ko ste vzeli svoj prvi odmerek, v prostor poleg kapsul.
English: As unchanged contraceptive effect may not be guaranteed, an additional contraceptive method, such as a barrier method, is recommended.
Slovenian: Ker ni mogoče zagotoviti nespremenjenega učinka kontraceptiva, se priporoča dodatna kontracepcijska metoda, kot je pregradna metoda.
English: Based on the populationpharmacokinetic (PK) model, the volume of distribution (V/F) is approximately 349 L (SE: ± 2.73%).
Slovenian: Na podlagi farmakokinetičnega modela populacije je volumen porazdelitve (V/F) približno 349 l (SE: ± 2,73 %).
English: Perforations, fistulas, and intra-abdominal abscesses
Slovenian: Perforacije, fistule in intraabdominalni abscesi
English: Your doctor will determine if you need your dose adjusted, particularly during the first eight weeks of therapy with COMETRIQ.
Slovenian: Vaš zdravnik se bo odločil, ali je treba odmerek prilagoditi, zlasti v prvih osmih tednih zdravljenja z zdravilom COMETRIQ.
English: Sverige/Ruotsi/Svíþjóð Tlf/Puh/Tel/Sími: +46 8 451 60 00 Deutschland, Österreich
Slovenian: Sverige/Ruotsi/Svíþjóð Tlf/Puh/Tel/Sími: +46 8 451 60 00
English: Two dose reductions were required in 41% of patients.
Slovenian: Pri 41 % bolnikov je bilo treba odmerek zmanjšati dvakrat.
English: No specific dose adjustment for the use of cabozantinib in older people (≥ 65 years) is recommended.
Slovenian: Ni posebnih priporočil za prilagoditev odmerka pri uporabi kabozantiniba za starejše bolnike (≥ 65 let).
English: There is no information on the precise food-effect when taken 1 hour after administration of cabozantinib.
Slovenian: Ni informacij o natančnem učinku hrane, če se jo zaužije 1 uro po dajanju kabozantiniba.
English: Take all capsules in one row each day without food (patients should fast for at least 2 hours before through 1 hour after taking the capsules).
Slovenian: Vzemite vse kapsule v eni vrsti vsak dan, brez hrane (bolniki vsaj 2 uri, preden vzamejo kapsule, in 1 uro po tem ne smejo jesti).
English: The safety and efficacy of cabozantinib in children aged <18 years have not yet been established.
Slovenian: Varnost in učinkovitost zdravila kabozantiniba pri otrocih, starih < 18 let, še nista bili dokazani.
English: Component of a 28 day pack, can't be sold separately.
Slovenian: Sestavni del 28-dnevnega pakiranja, ni za posamično prodajo.
English: This effect was not associated with a change in cardiac wave form morphology or new rhythms.
Slovenian: Ta učinek ni bil povezan s spremembo morfologije oblike zobcev srca ali novimi ritmi.
English: Patients with both sporadic and hereditary forms of MTC will be eligible for the study.
Slovenian: Bolniki s sporadično in dedno obliko MTC bodo primerni za študijo.
English: For patients in whom Rearranged during Transfection (RET) mutation status is not known or is negative, a possible lower benefit should be taken into account before individual treatment decision (see important information in sections 4.4 and 5.1).
Slovenian: Za bolnike, pri katerih status mutacije prerazporeditve med transfekcijo (RET, Rearranged during Transfection) ni znan ali je negativen, je treba pred odločitvijo za zdravljenje posameznika upoštevati možnost manjše koristi (za pomembne informacije glejte poglavji 4.4 in 5.1).
English: COMETRIQ is not recommended for children or adolescents.
Slovenian: Uporaba zdravila COMETRIQ se ne priporoča za otroke in mladostnike.
English: The effect of cabozantinib on the pharmacokinetics of contraceptive steroids has not been investigated.
Slovenian: Učinka kabozantiniba na farmakokinetiko kontraceptivnih steroidov niso preučili.
English: Samples will undergo thorough evaluation for RET and RAS mutations.
Slovenian: Vzorci se bodo natančno pregledali glede mutacij RET in RAS.
English: The carcinogenic potential of cabozantinib has been evaluated in two species: rasH2 transgenic mice and Sprague-Dawley rats.
Slovenian: Rakotvorni potencial kabozantiniba se je ocenjeval pri dveh vrstah: transgenih miših rasH2 in podganah vrste Sprague-Dawley.
English: More information on the blister cards including how many capsules you will take and how many capsules there are in total in each blister card are described below in section 6.
Slovenian: Več informacij o pretisnih zgibankah, vključno s številom kapsul, ki jih morate vzeti in koliko je vseh kapsul v posamični pretisni zgibanki, je opisanih spodaj v poglavju 6.
English: Probability
Slovenian: Verjetnost
English: Both men and women should be advised to seek advice and consider fertility preservation before treatment.
Slovenian: Tako ženskam kot moškim je treba svetovati, da se posvetujejo in pred zdravljenjem razmislijo o ukrepih za ohranitev plodnosti.
English: Your doctor may also prescribe other medicines to help control your side effects.
Slovenian: Vaš zdravnik vam bo morda predpisal tudi druga zdravila za obvladovanje neželenih učinkov.
English: These patients (n=16) showed significant prolongation of PFS (HR of 0.15) and an objective response rate of 31%.
Slovenian: Pri teh bolnikih (n = 16) se je pokazalo značilno podaljšanje PFS (HR 0,15) in objektivne stopnje odziva za 31 %.
English: Pharmacokinetics in special patient populations
Slovenian: Farmakokinetika pri posebnih skupinah bolnikov
English: • Changes in test results that measure blood clotting or blood cells
Slovenian: • spremenjeni rezultati preiskav, s katerimi merijo strjevanje krvi ali krvne celice
English: These may be signs of a gastrointestinal perforation, a hole that develops in your stomach or intestine that could be life-threatening.
Slovenian: To so lahko znaki perforacije prebavil, luknje, ki se razvije v želodcu ali črevesju in je lahko življenjsko nevarna.
English: Results will be used to evaluate the exposure to cabozantinib at the 60 and 140 mg dose levels and to further characterize the population PK models and exposure response relationships of cabozantinib and possible metabolites in this population.
Slovenian: Rezultati bodo uporabljeni za oceno izpostavljenosti kabozantinibu pri odmerku 60 in 140 mg in za nadaljnjo določanje značilnosti populacijskih FK modelov in razmerje v odzivu na izpostavljenost kabozantinibu in možne presnovke pri tej populaciji.
English: There is no specific treatment for cabozantinib overdose and possible symptoms of overdose have not been established.
Slovenian: Specifičnega zdravljenja za prevelik odmerek kabozantiniba ni, možnih simptomov prevelikega odmerjanja pa niso določili.
English: Push capsule through foil
Slovenian: Kapsule potisnite skozi folijo
English: The plasma terminal half-life of cabozantinib in single dose studies in healthy volunteers is approximately 120 hours.
Slovenian: Končni razpolovni čas kabozantiniba v plazmi v študijah enega odmerka pri zdravih prostovoljcih je približno 120 ur.
English: Keep in mind that treatment with COMETRIQ may make you feel tired or weak.
Slovenian: Ne pozabite, da lahko zdravljenje z zdravilom COMETRIQ povzroči utrujenost ali šibkost.
English: If you take COMETRIQ whilst using oral contraceptives, the oral contraceptives may be ineffective.
Slovenian: Če jemljete zdravilo COMETRIQ med uporabo peroralnih kontraceptivov, so lahko peroralni kontraceptivi neučinkoviti.
English: COMETRIQ capsules are also available in 28 day packs:
Slovenian: Zdravilo COMETRIQ kapsule so na voljo tudi kot 28-dnevno pakiranje:
English: If you experience serious side effects, your doctor may decide to change your dose or stop treatment earlier than originally planned.
Slovenian: Če se pojavijo resni neželeni učinki, bo morda zdravnik spremenil odmerek ali zdravljenje ustavil prej, kot je bilo načrtovano.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with cabozantinib in one or more subsets of the paediatric population in the treatment of malignant solid tumours (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij s kabozantinibom za eno ali več podskupin pediatrične populacije za zdravljenje malignih trdih tumorjev (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: The occurrence of some serious adverse reactions (like GI fistula) might be dependent on the cumulative dose and might present in a later stage of treatment.
Slovenian: Pojav nekaterih resnih neželenih reakcij (kot je gastrointestinalna fistula) je lahko odvisen od kumulativnega odmerka in se lahko izrazi v kasnejši dobi zdravljenja.
English: All patients should be monitored for hypertension and treated as needed with standard anti-hypertensive therapy.
Slovenian: Vse bolnike je treba spremljati glede pojava hipertenzije in jih po potrebi zdraviti s standardnimi antihipertenzivi.
English: • Atrial fibrillation (a fast and erratic heartbeat)
Slovenian: • atrijska fibrilacija (hitro in neredno bitje srca)
English: In addition, samples will be evaluated for mutations in RAS gene hotspots (HRAS, KRAS, and NRAS genes).
Slovenian: Vzorci bodo ocenjeni tudi za mutacije RAS na določenih mestih gena (hotspots) (geni HRAS, KRAS in NRAS).
English: Further genetic analysis showed that a small proportion of patients harboured somatic tumour mutations in HRAS, KRAS, or NRAS.
Slovenian: Nadaljnje genetske analize so pokazale, da je imel majhen delež bolnikov somatske mutacije tumorja v HRAS, KRAS ali NRAS.