FrancophonIA/ELRC3.0 huggingface dataset:
English: They have the product code “IGP110.50” printed in blue under two blue bars on the body and the company logo ( ) printed in black on the cap.
Croatian: Imaju šifru proizvoda „IGP110.50“ otisnutom plavom bojom ispod dvije plave linije na tijelu i logotip tvrtke ( ) otisnutim crnom bojom na kapici.
English: Dental caries
Croatian: Zubni karijes
English: Ultibro Breezhaler, dosed in the morning, reduced dynamic hyperinflation and improved the length of time exercise could be maintained from the first dose onwards.
Croatian: Ultibro Breezhaler, primijenjen ujutro, smanjio je dinamičku hiperinflaciju i povećao vrijeme tijekom kojeg se može održavati napor od prve doze nadalje.
English: The capsules must be administered only using the Ultibro Breezhaler inhaler (see section 6.6).
Croatian: Kapsule se moraju primjenjivati isključivo korištenjem inhalatora Ultibro Breezhaler (vidjeti dio 6.6).
English: Based on the magnitude of these changes, no clinically relevant drug interaction is expected when glycopyrronium is co-administered with cimetidine or other inhibitors of the organic cation transport.
Croatian: Na temelju opsega tih promjena, ne očekuje se nikakva klinički relevantna interakcija kada se glikopironij primjenjuje istodobno s cimetidinom ili drugim inhibitorima transporta organskih kationa.
English: 6 x 1 capsules + 1 inhaler 10 x 1 capsules + 1 inhaler 12 x 1 capsules + 1 inhaler 30 x 1 capsules + 1 inhaler 90 x 1 capsules + 1 inhaler
Croatian: 6 x 1 kapsula + 1 inhalator 10 x 1 kapsula + 1 inhalator 12 x 1 kapsula + 1 inhalator 30 x 1 kapsula + 1 inhalator 90 x 1 kapsula + 1 inhalator
English: I felt small pieces of the capsule on my tonguedoes this matter?
Croatian: Osjetio/la sam komadiće kapsule na jeziku - je li to važno?
English: Cardiac disorders Ischaemic heart disease
Croatian: Srčani poremećaji Ishemijska bolest srca
English: Oxidative metabolites were found in incubations with recombinant CYP1A1, CYP2D6, and CYP3A4.
Croatian: Oksidativni metaboliti su nađeni u inkubaciji s rekombinantnim CYP1A1, CYP2D6 i CYP3A4.
English: If signs suggesting allergic reactions occur, in particular, angioedema (difficulties in breathing or swallowing, swelling of the tongue, lips and face) urticaria or skin rash, treatment should be discontinued immediately and alternative therapy instituted.
Croatian: Ako se pojave znakovi koji ukazuju na alergijsku reakciju osobito angioedem (poteškoće u disanju ili gutanju, oticanje jezika, usana i lica), urtikarija ili osip na koži, liječenje treba odmah prekinuti i započeti alternativnu terapiju.
English: - The other ingredients of the inhalation powder are lactose monohydrate and magnesium stearate (see section 2 under “Ultibro Breezhaler contains lactose”).
Croatian: - Drugi sastojci praška inhalata su laktoza hidrat i magnezijev stearat (vidjeti dio 2 ispod „Ultibro Breezhaler sadrži laktozu“).
English: Therefore, long-acting beta2-adrenergic agonists should be used with caution in patients with known or suspected prolongation of the QT interval or treated with medicinal products affecting the QT interval.
Croatian: Stoga dugodjelujuće beta2-adrenergičke agoniste treba koristiti s oprezom u bolesnika s poznatim ili suspektnim produljenjem QT intervala ili u onih koji se liječe lijekom koji utječe na QT interval.
English: When compared with the serum clearance of indacaterol of 23.3 litres/hour, it is evident that renal clearance plays a minor role (about 2 to 5% of systemic clearance) in the elimination of systemically available indacaterol.
Croatian: U usporedbi sa serumskim klirensom indakaterola od 23,3 litre/sat, očito je da bubrežni klirens ima manju ulogu u eliminaciji sistemski dostupnog indakaterola (oko 2 do 5% sistemskog klirensa).
English: The effect was significantly greater for Ultibro Breezhaler, when compared to indacaterol, glycopyrronium or tiotropium alone (difference 110 ml, for each comparison).
Croatian: Učinak je bio značajno veći za Ultibro Breezhaler kada se uspoređuje sa samim indakaterolom, glikopironijem ili tiotropijem (razlika 110 ml, za svaku usporedbu).
English: However, as shown in a clinical study in populations with different UGT1A1 genotypes, systemic exposure to indacaterol is not significantly affected by the UGT1A1-genotype.
Croatian: Međutim, kako je uočeno u kliničkom ispitivanju na populacijama s različitim genotipovima UGT1A1, UGT1A1 genotip ne utječe značajno na sistemsku izloženost indakaterolu.
English: In clinical studies, the amount of indacaterol excreted unchanged via urine was generally lower than 2.5% of the delivered dose.
Croatian: U ispitivanjima, količina indakaterola koja se izlučila nepromijenjena u mokraću u pravilu je bila manja od 2,5% isporučene doze.
English: Beta-adrenergic blockers
Croatian: Beta-adrenergički blokatori
English: Glucuronide and/or sulfate conjugates of glycopyrronium were found in urine of humans after repeated inhalation, accounting for about 3% of the delivered dose.
Croatian: Glukuronid i/ili sulfatni konjugati glikopironija bili su pronađeni u mokraći ljudi nakon opetovane inhalacije, što je predstavljalo oko 3% isporučene doze.
English: - When you start a new pack, use the new Ultibro Breezhaler inhaler that is supplied in the pack.
Croatian: - Kada otvorite novo pakiranje, upotrijebite novi Ultibro Breezhaler inhalator koji je priložen u pakiranju.
English: After intravenous dosing, the steady-state volume of distribution of glycopyrronium was 83 litres and the volume of distribution in the terminal phase was 376 litres.
Croatian: Nakon intravenskog doziranja, volumen distribucije glikopironija u stanju dinamičke ravnoteže bio je 83 litre, a volumen distribucije u terminalnoj fazi bio je 376 litara.
English: Parasympathetic nerves are the major bronchoconstrictive neural pathway in airways, and cholinergic tone is the key reversible component of airflow obstruction in COPD.
Croatian: Parasimpatički živci su glavni bronhokonstriktivni neuralni put u dišnim putevima, a kolinergički tonus je ključna reverzibilna komponenta otežanog prolaza zraka u KOPB-u.
English: Overall the effect on heart rate over time did not show a consistent pharmacodynamic effect of Ultibro Breezhaler.
Croatian: Sveukupno, učinak na srčanu frekvenciju tijekom vremena nije pokazao dosljedan farmakodinamički učinak Ultibro Breezhalera.
English: Ultibro Breezhaler should not be used for the treatment of asthma due to the absence of data in this indication.
Croatian: Astma Ultibro Breezhaler ne smije se koristiti za liječenje astme zbog nedostatka podataka u ovoj indikaciji.
English: • Ultibro Breezhaler capsules must always be stored in the blister card and only removed immediately before use.
Croatian: • Ultibro Breezhaler kapsule moraju se uvijek čuvati u blister kartici i izvaditi tek neposredno prije primjene.
English: Hypokalaemic treatment
Croatian: Hipokalijemičko liječenje
English: In vitro studies have shown that indacaterol has multi-fold greater agonist activity at beta2-receptors compared to beta1 and beta3-receptors.
Croatian: In vitro ispitivanja pokazala su da indakaterol ima višestruko veće agonističko djelovanje na beta2-receptore u usporedbi s beta1 i beta3-receptorima.
English: This medicinal product has no or negligible influence on influence on the ability to drive and use machines.
Croatian: Ovaj lijek ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: • difficulty breathing with wheezing or coughing.
Croatian: • otežano disanje uz piskanje ili kašalj.
English: • Never place the capsule into your mouth or the mouthpiece of the inhaler.
Croatian: • Nikad ne stavljajte kapsulu u usta ili nastavak inhalatora.
English: Do not use this medicine if you notice that the pack is damaged or shows signs of tampering.
Croatian: Ovaj lijek se ne smije upotrijebiti ako primijetite da je pakiranje oštećeno ili ako su vidljivi znakovi neovlaštenog otvaranja.
English: Therefore, Ultibro Breezhaler should only be used during pregnancy if the expected benefit to the patient justifies the potential risk to the foetus.
Croatian: Stoga se Ultibro Breezhaler smije koristiti tijekom trudnoće samo ako očekivana korist za bolesnika opravdava potencijalni rizik za fetus.
English: Long-acting beta2-adrenergic agonists may increase the risk of asthma-related serious adverse events, including asthma-related deaths, when used for the treatment of asthma.
Croatian: Dugodjelujući beta2-adrenergički agonisti mogu povećati rizik od ozbiljnih štetnih događaja povezanih s astmom, uključujući smrtne slučajeve povezane s astmom, kada se koriste za liječenje astme.
English: In vitro metabolism studies showed consistent metabolic pathways for glycopyrronium bromide between animals and humans.
Croatian: In vitro ispitivanja metabolizma pokazala su dosljedne metaboličke puteve za glikopironijev bromid između životinja i ljudi.
English: Exercise tolerance
Croatian: Tolerancija napora
English: The effective half-life, calculated from the accumulation of indacaterol after repeated dosing ranged from 40 to 52 hours which is consistent with the observed time-to-steady state of approximately 12-15 days.
Croatian: Efektivni poluvijek, izračunat iz nakupljanja indakaterola nakon ponovljenih doza, bio je u rasponu od 40 do 52 sata, što je u skladu sa zapaženim vremenom do stanja dinamičke ravnoteže od približno 12-15 dana.
English: Excipient(s) with known effect Each capsule contains 23.5 mg lactose (as monohydrate).
Croatian: Pomoćna(e) tvar(i) s poznatim učinkom Jedna kapsula sadrži 23,5 mg laktoze (u obliku hidrata).
English: This medicine is used to make breathing easier for adult patients who have breathing difficulties due to a lung disease called chronic obstructive pulmonary disease (COPD).
Croatian: Ovaj se lijek primjenjuje da bi olakšao disanje odraslim bolesnicima koji imaju poteškoće u disanju zbog bolesti pluća koja se naziva kroničnom opstruktivnom plućnom bolešću (KOPB).
English: INTERMEDIATE CARTON OF MULTIPACK (WITHOUT BLUE BOX)
Croatian: SREDNJA KUTIJA U VIŠESTRUKOM PAKIRANJU (BEZ PLAVOG OKVIRA)
English: The pharmacological effects of beta2-adrenoceptor agonists, including indacaterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cyclic AMP).
Croatian: Farmakološki učinci beta2-adrenoceptorskih agonista, što uključuje indakaterol, mogu se barem djelomično pripisati stimulaciji unutarstanične adenil ciklaze, enzima koji katalizira konverziju adenozin trifosfata (ATP) u ciklički-3', 5'-adenozin monofosfat (ciklički AMP).
English: To be taken into account with concomitant use
Croatian: Uzeti u obzir kod istodobne primjene
English: In addition, beta-adrenergic agonists have been reported to produce electrocardiographic (ECG) changes, such as flattening of the T wave, prolongation of QT interval and ST segment depression, although the clinical significance of these observations is unknown.
Croatian: Također je prijavljeno da su beta-adrenergički agonisti uzrokovali promjene na elektrokardiogramu (EKG), kao što su izravnati T val, produljenje QT intervala i depresija ST segmenta, iako nije poznata klinička važnost tih pojava.
English: It is not harmful.
Croatian: To se može dogoditi i nije štetno.
English: Description of selected adverse reactions Cough was common, but usually of mild intensity.
Croatian: Kašalj je bio čest, ali obično blagog intenziteta.
English: Ultibro Breezhaler can be used at the recommended dose in elderly patients (75 years of age and older).
Croatian: Ultibro Breezhaler se može koristiti u preporučenoj dozi u starijih bolesnika (u dobi od 75 i više godina).
English: A population pharmacokinetic analysis showed that there is no clinically relevant effect of age (adults up to 88 years), sex, weight (32-168 kg) or race on the pharmacokinetics of indacaterol.
Croatian: Analiza populacijske farmakokinetike pokazala je da dob (odrasli do 88 godina), spol, težina (32-168 kg) ili rasa nemaju klinički značajnog učinka na farmakokinetiku indakaterola.
English: • pain in arms or legs.
Croatian: • bol u rukama ili nogama.
English: A population pharmacokinetic analysis of data in COPD patients identified body weight and age as factors contributing to inter-patient variability in systemic exposure.
Croatian: Analiza podataka o farmakokinetici u populaciji bolesnika s KOPB-om utvrdila je tjelesnu težinu i dob kao čimbenike koji doprinose razlikama u sistemskoj izloženosti među bolesnicima.
English: The decrease in serum potassium is usually transient, not requiring supplementation.
Croatian: Sniženje kalija u serumu je obično prolazno i ne zahtijeva nadomještanje kalija.
English: There was no evidence for tachyphylaxis to the effect of Ultibro Breezhaler over time when compared to placebo or its monotherapy components.
Croatian: Nije bilo dokaza tahifilaksije na učinak Ultibro Breezhalera tijekom vremena u usporedbi s placebom ili monoterapijama njegovim komponentama.
English: The use of Ultibro Breezhaler by breast-feeding women should only be considered if the expected benefit to the woman is greater than any possible risk to the infant (see section 5.3).
Croatian: Primjenu Ultibro Breezhalera u dojilja treba uzeti u obzir samo ako je očekivana korist za ženu veća od bilo kojeg mogućeg rizika za dojenče (vidjeti dio 5.3).
English: Concomitant hypokalaemic treatment with methylxanthine derivatives, steroids, or non-potassiumsparing diuretics may potentiate the possible hypokalaemic effect of beta2-adrenergic agonists, therefore use with caution (see section 4.4).
Croatian: Istodobno hipokalijemičko liječenje derivatima metilksantina, steroidima ili diureticima koji ne štede kalij može potencirati mogući hipokalijemički učinak beta2-adrenergičkih agonista, pa ih zato treba primjenjivati s oprezom (vidjeti dio 4.4).
English: Instructions for handling and use
Croatian: Upute za rukovanje i primjenu
English: Patients with unstable ischaemic heart disease, left ventricular failure, history of myocardial infarction, arrhythmia (excluding chronic stable atrial fibrillation), a history of long QT syndrome or whose QTc (Fridericia method) was prolonged (>450 ms) were excluded from the clinical trials, and therefore there is no experience in these patient groups.
Croatian: Bolesnici s nestabilnom ishemijskom bolešću srca, zatajivanjem lijeve klijetke, anamnezom infarkta miokarda, aritmijom (isključujući kroničnu stabilnu fibrilaciju atrija), anamnezom sindroma dugog QT intervala ili bolesnici čiji je QTc (Fridericijina metoda) bio produljen (>450 ms) bili su isključeni iz kliničkih ispitivanja pa stoga nema iskustava u tim skupinama bolesnika.
English: You should not use Ultibro Breezhaler unless your doctor tells you to do so.
Croatian: Nemojte koristiti Ultibro Breezhaler osim ako Vam to nije rekao liječnik.
English: Increased cyclic AMP levels cause relaxation of bronchial smooth muscle.
Croatian: Povišene razine cikličkog AMP-a uzrokuju opuštanje bronhijalnih glatkih mišića.
English: Concomitant administration of orally inhaled indacaterol and glycopyrronium, under steady-state conditions of both active substances, did not affect the pharmacokinetics of either active substance.
Croatian: Istodobna primjena oralno inhaliranog indakaterola i glikopironija, u uvjetima stanja dinamičke ravnoteže obiju djelatnih tvari, nije utjecala na farmakokinetiku bilo koje od djelatne tvari.
English: Do not use this medicine after the expiry date which is stated on the carton and blister after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake „Rok valjanosti“/„EXP“.
English: Beta-adrenergic blockers may weaken or antagonise the effect of beta2-adrenergic agonists.
Croatian: Beta-adrenergički blokatori mogu oslabiti ili djelovati antagonistički na učinak beta2-adrenergičkih agonista.
English: When indacaterol and glycopyrronium are administered together in Ultibro Breezhaler, they provide additive efficacy due to their different mode of action targeting different receptors and pathways to achieve smooth muscle relaxation.
Croatian: Kada se indakaterol i glikopironij primjenjuju zajedno u Ultibro Breezhaleru, pružaju dodatnu djelotvornost zbog svog različitog mehanizma djelovanja koji je usmjeren na različite receptore i puteve da bi se postiglo opuštanje glatkih mišića.
English: Adverse reactions detected during clinical trials and from post-marketing sources are listed by MedDRA system organ class (Table 1).
Croatian: Nuspojave otkrivene u kliničkim ispitivanjima i nakon stavljanja lijeka u promet navedene su prema klasifikaciji organskih sustava prema MedDRA-i (Tablica 1).
English: Check Check capsule is empty
Croatian: Provjera Provjerite je li kapsula prazna
English: This medicine contains two active substances called indacaterol and glycopyrronium.
Croatian: Ovaj lijek sadrži dvije djelatne tvari koje se zovu indakaterol i glikopironij.
English: There were no relevant effects of Ultibro Breezhaler on mean heart rate over 24 h and heart rate assessed after 30 minutes, 4 h and 24 h.
Croatian: Nije bilo značajnih učinaka Ultibro Breezhalera na srednju srčanu frekvenciju tijekom 24 h te na srčanu frekvenciju određenu nakon 30 minuta, 4 h i 24 h.
English: The elimination pattern suggests sustained lung absorption and/or transfer of glycopyrronium into the systemic circulation at and beyond 24 h after inhalation.
Croatian: Način eliminacije ukazuje na održanu plućnu apsorpciju i/ili prijenos glikopironija u sistemsku cirkulaciju u trenutku 24 sata od inhalacije i nakon toga.
English: Following inhalation of Ultibro Breezhaler, the absolute bioavailability of indacaterol has been estimated to range from 61 to 85% of the delivered dose, and that of glycopyrronium was about 47% of the delivered dose.
Croatian: Nakon inhalacije Ultibro Breezhalera apsolutna bioraspoloživost indakaterola procijenjena je na raspon od 61 do 85% isporučene doze, i za glikopironij oko 47% isporučene doze.
English: Increased incidences of benign ovarian leiomyoma and focal hyperplasia of ovarian smooth muscle in rats were consistent with similar findings reported for other beta2-adrenergic agonists.
Croatian: Povećane incidencije dobroćudnog lejomioma jajnika i fokalne hiperplazije glatkog mišića jajnika u štakora bile su u skladu sa sličnim nalazima prijavljenim za druge beta2-adrenergičke agoniste.
English: Use of cardioselective beta blockers may be considered for treating beta2adrenergic effects, but only under the supervision of a physician and with extreme caution since the use of beta-adrenergic blockers may provoke bronchospasm.
Croatian: Treba razmotriti primjenu kardioselektivnih beta blokatora za liječenje beta2-adrenergičkih učinaka, ali samo uz liječnički nadzor i uz krajnji oprez, jer primjena beta-adrenergičkih blokatora može izazvati bronhospazam.
English: The components of Ultibro Breezhaler are not known to have a QT-prolongation potential at clinical dose levels.
Croatian: Za komponente Ultibro Breezhalera nije poznato da imaju potencijal produljenja QT potencijala pri kliničkim razinama doze.
English: In four of these studies patients were enrolled who had a clinical diagnosis of moderate to severe COPD.
Croatian: U četiri od navedenih ispitivanja bili su uključeni bolesnici koji su imali kliničku dijagnozu umjerenog do teškog KOPB-a.
English: Due to the differential density of beta2-adrenoceptors and M3-receptors in central versus peripheral airways, beta2-agonists should be more effective in relaxing peripheral airways, whilst an anticholinergic compound may be more effective in central airways.
Croatian: Zbog diferencijalne gustoće beta2-adrenoceptora i M3-receptora u središnjim naspram perifernih dišnih puteva, beta2-agonisti trebali bi biti djelotvorniji u opuštanju perifernih dišnih puteva, dok bi antikolinergički spoj mogao biti djelotvorniji u središnjim dišnim putevima.
English: Administration of Ultibro Breezhaler may result in paradoxical bronchospasm which can be life-threatening.
Croatian: Primjena Ultibro Breezhalera može dovesti do paradoksalnog bronhospazma koji može biti opasan po život.
English: Treatment for 90 days [90 x 1 capsules + 1 inhaler only].
Croatian: Liječenje za 90 dana [samo za 90 x 1 kapsula + 1 inhalator]
English: If you use more Ultibro Breezhaler than you should If you have inhaled too much of this medicine or if someone else accidentally uses your capsules, you must immediately either tell your doctor or go to the nearest emergency unit.
Croatian: Ako ste inhalirali previše ovog lijeka ili ako netko zabunom uzme Vaše kapsule, morate odmah obavijestiti svog liječnika ili otići u najbližu hitnu pomoć.
English: Infections and infestations Upper respiratory tract infection
Croatian: Infekcije i infestacije Infekcije gornjeg dišnog sustava
English: Indacaterol is a partial agonist at the human beta2-adrenergic receptor with nanomolar potency.
Croatian: Indakaterol je djelomičan agonist ljudskog beta2-adrenergičkog receptora s nanomolarnom snagom.
English: There were no major differences in total systemic exposure (AUC) between Japanese and Caucasian subjects.
Croatian: Nije bilo većih razlika u ukupnoj sistemskoj izloženosti (AUC) između ispitanika Japanaca i bijelaca.
English: Caution required with concomitant use
Croatian: Potreban oprez kod istodobne primjene
English: After oral administration of radiolabelled indacaterol in a human ADME (absorption, distribution, metabolism, excretion) study, unchanged indacaterol was the main component in serum, accounting for about one third of total drug-related AUC over 24 hours.
Croatian: Nakon oralne primjene radiooznačenog indakaterola u ADME (apsorpcija, distribucija, metabolizam, ekskrecija) ispitivanju u ljudi najveća komponenta u serumu bio je nepromijenjeni indakaterol, što je predstavljalo oko jednu trećinu ukupnog uz lijek vezanog AUC-a tijekom 24 sata.
English: During long-term clinical studies, more patients on Ultibro Breezhaler experienced clinically notable changes in blood glucose (4.9%) at the recommended dose than on placebo (2.7%).
Croatian: Tijekom dugoročnih kliničkih ispitivanja, više je bolesnika koji su koristili Ultibro Breezhaler imalo klinički značajne promjene glukoze u krvi (4,9%) u preporučenoj dozi nego onih koji su primali placebo (2,7%).
English: Glycopyrronium was not teratogenic in rats or rabbits following inhalation administration.
Croatian: Glikopironij nije bio teratogen u štakora ili zečeva nakon inhalacijske primjene.
English: Over 64 weeks, this reduction was 0.76 puffs per day (p<0.001) compared to tiotropium.
Croatian: Tijekom 64 tjedna to je smanjenje bilo 0,76 udisaja dnevno (p<0,001) u usporedbi s tiotropijem.
English: Impairment of the hepatic metabolism of glycopyrronium is not thought to result in a clinically relevant increase of systemic exposure.
Croatian: Smatra se da oštećenje hepatičkog metabolizma glikopironija ne rezultira klinički relevantnim povećanjem sistemske izloženosti.
English: Oropharyngeal pain including throat irritation
Croatian: Orofaringealna bol uključujući nadražaj grla
English: The safety experience with Ultibro Breezhaler was comprised of exposure of up to 15 months at the recommended therapeutic dose.
Croatian: Iskustvo sa sigurnošću Ultibro Breezhalera obuhvaća izloženost u trajanju do 15 mjeseci pri preporučenoj terapijskoj dozi.
English: Inhalation of high doses of beta2-adrenergic agonists may produce increases in plasma glucose.
Croatian: Inhalacija visokih doza beta2-adrenergičkih agonista može uzrokovati povećanje glukoze u plazmi.
English: 3H]-labelled glycopyrronium bromide, the mean urinary excretion of radioactivity in 48 hours amounted to 85% of the dose.
Croatian: 3H], srednje urinarno izlučivanje radioaktivnosti u 48 sati iznosilo je 85% doze.
English: • feeling tired or very thirsty, having an increased appetite without gaining weight and passing more urine than usual - these may be signs of high level of sugar in the blood (hyperglycaemia).
Croatian: • osjećaj umora ili velike žeđi, povećani apetit bez porasta tjelesne težine i mokrenje više nego inače - to bi mogli biti znakovi visoke razine šećera u krvi (hiperglikemija).