FrancophonIA/ELRC3.0 huggingface dataset:
English: It should be noted that there was no dose-finding study in mucormycosis, and patients were administered the same dose of isavuconazole as was used for the treatment of invasive aspergillosis.
Danish: Det bør bemærkes, at der ikke var nogen dosisbestemmende undersøgelse af mucormycose, at patienterne fik samme dosis isavuconazol som ved behandling af invasiv aspergillose.
English: Breast-feeding should be discontinued during treatment with CRESEMBA.
Danish: Amning skal ophøre under behandling med CRESEMBA.
English: Isavuconazole is the active moiety formed after oral or intravenous administration of isavuconazonium sulfate (see section 5.2).
Danish: Isavuconazol er den aktive del, der dannes efter oral eller intravenøs administration af isavuconazoniumsulfat (se pkt.
English: The vial should be shaken to dissolve the powder completely.
Danish: Hætteglasset skal omrystes, så pulveret opløses helt.
English: In a double-blind, randomized, active-controlled clinical study of 516 patients with invasive fungal disease caused by Aspergillus species or other filamentous fungi, elevated liver transaminases (alanine aminotransferase or aspartate aminotransferase) > 3 × Upper Limit of Normal (ULN) were reported at the end of study treatment in 4.4% of patients who received CRESEMBA.
Danish: I et dobbeltblindt, randomiseret, aktiv-kontrolleret klinisk studie med 516 patienter med invasiv svampesygdom, der skyldtes Aspergillus-arter eller andre filamentøse svampe, blev der indberettet forhøjede levertransaminaser (alaninaminotransferase eller aspartataminotransferase) > 3 × Upper Limit of Normal (ULN) efter afsluttet forsøgsbehandling hos 4,4% af de patienter, der fik CRESEMBA.
English: In vitro / in vivo studies indicate that CYP3A4, CYP3A5, and subsequently uridine diphosphateglucuronosyltransferases (UGT), are involved in the metabolism of isavuconazole.
Danish: Studier in vitro/in vivo viser, at CYP3A4, CYP3A5 og efterfølgende uridin-diphosphatglucuronosyltransferaser (UGT) er involveret i metabolismen for isavuconazol.
English: Isavuconazole 200 mg (n = 37)
Danish: Isavuconazol 200 mg (n = 37)
English: The clinical data for isavuconazole in the treatment of mucormycosis are limitedto one prospective non-controlled clinical study in 37 patients with proven or probable mucormycosis who received isavuconazole for primary treatment, or because other antifungal treatments (predominantly amphotericin B) were inappropriate.
Danish: De kliniske data for isavuconazol til behandlingen af mucormycose er begrænsede til et enkelt prospektivt ukontrolleret klinisk studie med 37 patienter med påvist eller sandsynlig mucormycose, der fik isavuconazol i den primære behandling, eller fordi andre antimykotiske behandlinger (fortrinsvis amphotericin B) ikke var egnede.
English: The elevations in liver transaminases rarely required discontinuation of CRESEMBA.
Danish: Kun i sjældne tilfælde krævede forhøjelserne i levertransaminaser seponering af CRESEMBA.
English: The adjusted treatment difference (voriconazole−isavuconazole) was 4.0% (95% confidence interval: −7.9; 15.9).
Danish: Den justerede behandlingsdifference (voriconazol−isavuconazol) var 4,0% (95% konfidensinterval: -7,9; 15,9).
English: These data indicate that concentrations of isavuconazole required for inhibition in vitro are very variable between genera/species within the order of Mucorales, and generally higher than concentrations required to inhibit Aspergillus species.
Danish: Disse data indikerer, at de koncentrationer af isavuconazol, der er nødvendige for hæmning in vitro, varierer meget mellem slægter/arter inden for ordenen Mucorales, og er generelt højere end de koncentrationer, der er nødvendige for at hæmme Aspergillus-arter.
English: Mycophenolate mofetil (MMF) (UGT substrate)
Danish: Mycophenolatmofetil (MMF) (UGT-substrat)
English: Reduced susceptibility to triazole antifungal agents has been associated with mutations in the fungal cyp51A and cyp51B genes coding for the target protein lanosterol 14-alpha-demethylase involved in ergosterol biosynthesis.
Danish: Nedsat følsomhed over for triazol-antimykotika har været forbundet med mutationer i de fungale cyp51A- og cyp51B-gener, der koder for målproteinet lanosterol 14-alpha-demethylase, som er involveret i ergosterols biosyntese.
English: The adjusted treatment difference (isavuconazole−voriconazole) was −2.7% (95 % confidence interval: −12.9; 7.5).
Danish: Den justerede behandlingsdifference (isavuconazol−voriconazol) var -2,7 % (95% konfidensinterval: -12,9; 7,5).
English: Concomitant use of CRESEMBA with CYP3A4 substrates such as the immunosuppressants tacrolimus, sirolimus or ciclosporin may increase the systemic exposure to these medicinal products.
Danish: Samtidig anvendelse af CRESEMBA og CYP3A4-substrater, for eksempel de immunsupprimerende midler tacrolimus, sirolimus eller ciclosporin, kan forhøje den systemiske eksponering for disse lægemidler.
English: Powder for concentrate for solution for infusion White to yellow powder
Danish: Pulver til koncentrat til infusionsvæske, opløsning Hvidt til gult pulver
English: Cresemba treatment will continue for as long as your doctor tells you.
Danish: Behandlingen med Cresemba vil fortsætte så længe, som lægen har sagt, at den skal.
English: • mucormycosis in patients for whom amphotericin B is inappropriate (see sections 4.4 and 5.1)
Danish: • mucormycose hos patienter, som amphotericin B ikke er egnet til (se pkt.
English: Administration of isavuconazonium sulfate to rats at a dose of 90 mg/kg/day (2.3-fold the human maintenance dose [200 mg] based on mg/m2/day) during pregnancy through the weaning period showed an increased perinatal mortality of the pups.
Danish: Administration af isavuconazoniumsulfat til rotter i en dosis på 90 mg/kg/dag (2,3 gange vedligeholdelsesdosis til mennesker [200 mg] baseret på mg/m2/dag) under drægtighed i afvænningsperioden viste øget perinatal mortalitet hos ungerne.
English: After the reconstituted concentrate is further diluted, the diluted solution may show fine white-to-translucent particulates of isavuconazole that do not sediment (but will be removed by in-line filtration).
Danish: Når det rekonstituerede koncentrat er yderligere fortyndet, kan den fortyndede opløsning fremstå med fine hvide til gennemsigtige partikler af isavuconazol, der ikke sedimenterer (men fjernes med et rækkefilter).
English: Isavuconazole demonstrates a fungicidal effect by blocking the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase, responsible for the conversion of lanosterol to ergosterol.
Danish: Isavuconazol udviser fungicid-effekter ved at blokere ergosterol-syntesen, som er en vigtig bestanddel af svampecellemembranen, ved at hæmme det cytochrom P 450-afhængige enzym lanosterol 14alpha-demethylase, der er ansvarlig for omdannelsen af lanosterol til ergosterol.
English: Deutschland Pfizer Pharma PFE GmbH Tel: +49 (0)800 8535555
Danish: Pfizer Pharma PFE GmbH Tel: +49 (0)800 8535555
English: The most common treatment-related adverse reactions were elevated liver chemistry tests (7.9%), nausea (7.4%), vomiting (5.5%), dyspnoea (3.2%), abdominal pain (2.7%), diarrhoea (2.7%), injection site reaction (2.2%), headache (2.0%), hypokalaemia (1.7%) and rash (1.7%).
Danish: De mest almindelige behandlingsrelaterede bivirkninger var forhøjede leverfunktionstest (7,9%), nausea (7,4%), opkastning (5,5%), dyspnø (3,2%), abdominalsmerter (2,7%), diarré (2,7%), reaktioner på injektionsstedet (2,2%), hovedpine (2,0%), hypokaliæmi (1,7%) og udslæt (1,7%).
English: Isavuconazole is a mild inhibitor of UGT.
Danish: Isavuconazol er en mild hæmmer af UGT.
English: For the 200 mg dosing regimen, the least squares mean (LSM) difference from placebo was 13.1 ms at 2 hours post dose [90% CI: 17.1, 9.1 ms].
Danish: For doseringsregimenet på 200 mg var forskellen i mindste kvadraters metode (LSM) i forhold til placebo 13,1 ms 2 timer efter dosering [90% CI: 17,1; 9,1 ms].
English: No dose adjustment is necessary in patients with mild or moderate hepatic impairment (Child-Pugh Classes A and B) (see sections 4.4 and 5.2).
Danish: Der er ikke behov for justering af dosis til patienter med mild eller moderat nedsat leverfunktion (Child-Pugh-klasse A og B) (se pkt.
English: Patients with familial short QT syndrome (see section 4.4).
Danish: Patienter med familiært kort QT-syndrom (se pkt.
English: Caution should be used in prescribing isavuconazole to patients with hypersensitivity to other azole antifungal agents.
Danish: Der skal udvises forsigtighed i forbindelse med ordination af isavuconazol til patienter med overfølsomhed over for andre azoler.
English: Concentrations of isavuconazole required to inhibit Aspergillus species and genera/species of the order Mucorales in vitro have been very variable.
Danish: De koncentrationer af isavuconazol, der er nødvendige for at hæmme Aspergillus-arter og slægter/arter af ordenen Mucorales in vitro, variere meget.
English: Therefore, caution is advised when CYP2B6 substrates, especially medicinal products with a narrow therapeutic index such as cyclophosphamide, are co-administered with CRESEMBA.
Danish: Der tilrådes derfor til forsigtighed, når CYP2B6-substrater, herunder især lægemidler med et smalt terapeutisk indeks (fx cyclophosphamid), administreres samtidig med CRESEMBA.
English: Isavuconazole concentrations may decrease (CYP3A induction by carbamazepine, phenytoin and long-acting barbiturates such as phenobarbital).
Danish: Koncentrationerne af isavuconazol kan falde (induktion af CYP3A fra carbamazepin, phenytoin og langtidsvirkende barbiturater såsom phenobarbital).
English: Following oral administration of CRESEMBA in healthy subjects, the active moiety isavuconazole is absorbed and reaches maximum plasma concentrations (Cmax) approximately 2-3 hours after single and multiple dosing (see Table 3).
Danish: Efter oral administration af CRESEMBA til raske personer absorberes den aktive del, isavuconazol, og når de maksimale plasmakoncentrationer (Cmax) cirka 2-3 timer efter enkelte og flere doser (se Tabel
English: The adverse reactions which most often led to permanent discontinuation of CRESEMBA treatment were confusional state (0.7%), acute renal failure (0.7%), increased blood bilirubin (0.5%), convulsion (0.5%), dyspnoea (0.5%), epilepsy (0.5%), respiratory failure (0.5%) and vomiting (0.5%).
Danish: De bivirkninger, der oftest første til permanent seponering af behandling med CRESEMBA, var konfusion (0,7%), akut nyreinsufficiens (0,7%), forhøjet blodbilirubin (0,5%), kramper (0,5%), dyspnø (0,5%), epilepsi (0,5%), respirationsinsufficiens (0,5%) og opkastning (0,5%).
English: An existing intravenous line should be flushed with sodium chloride 9 mg/mL (0.9%) solution for injection or 50 mg/mL (5%) dextrose solution.
Danish: En eksisterende intravenøs slange skal skylles med natriumchlorid 9 mg/ml (0,9%) injektionsvæske eller 50 mg/ml (5%) dextroseopløsning.
English: # See section Description of selected adverse reactions below
Danish: # Se nedenstående afsnit Beskrivelse af udvalgte bivirkninger
English: Ritonavir (at doses >200 mg every 12 hours) (strong CYP3A4/5 inducer)
Danish: Ritonavir (i doser på >200 mg hver 12. time) (potent CYP3A4/5-induktor)
English: Capsules can be taken with or without food.
Danish: Kapslerne kan tages med eller uden mad.
English: CRESEMBA has not been studied in patients with severe hepatic impairment (Child-Pugh Class C).
Danish: CRESEMBA er ikke blevet undersøgt hos patienter med stærkt nedsat leverfunktion (Child-Pughklasse C).
English: Metformin (OCT1, OCT2 and MATE1 substrate)
Danish: Metformin (OCT1-, OCT2- og MATE1substrat)
English: CRESEMBA was administered intravenously (equivalent to 200 mg isavuconazole) every 8 hours for the first 48 hours, followed by once-daily intravenous or oral treatment (equivalent to 200 mg isavuconazole).
Danish: CRESEMBA blev administreret intravenøst (svarende til 200 mg isavuconazol) hver 8. time i de første 48 timer efterfulgt af intravenøs eller oral behandling én gang dagligt (svarende til 200 mg isavuconazol).
English: Treatment of invasive aspergillosis
Danish: Behandling af invasiv aspergillose
English: The reconstituted solution should be inspected visually for particulate matter and discoloration.
Danish: Den rekonstituerede opløsning skal inspiceres visuelt for tegn på partikler og misfarvning.
English: No dose adjustment is necessary in patients with renal impairment, including patients with end-stage renal disease (see section 5.2).
Danish: Der er ikke behov for justering af dosis til patienter med nedsat nyrefunktion, herunder patienter med nyresygdom i slutstadiet (se pkt.
English: For individual Mucorales species, the clinical efficacy data are very limited, often to one or two patients (see section 5.1).
Danish: De kliniske effektdata er meget begrænsede, ofte til en eller to patienter, for individuelle Mucoralesarter (se pkt.
English: Medicinal products metabolised by CYP2B6
Danish: Lægemidler, der metaboliseres af CYP2B6
English: Isavuconazole 600 mg (n = 32)
Danish: Isavuconazol 600 mg (n = 32)
English: CRESEMBA is contraindicated in patients with familial short QT syndrome (see section 4.3).
Danish: CRESEMBA er kontraindiceret til patienter med familiært kort QT-syndrom (se pkt.
English: No CRESEMBA dose adjustment necessary; caution is advised as adverse drug reactions may increase.
Danish: Justering af CRESEMBA-dosis ikke nødvendig; der tilrådes til forsigtighed, da forekomsten af lægemiddelbivirkninger kan stige.
English: System Organ Class
Danish: Systemorgankl asse
English: NNRTI concentrations may decrease (CYP2B6 induction by isavuconazole) or increase.
Danish: NNRTI-koncentrationerne kan falde (isavuconazols CYP2B6induktion) eller stige.
English: Dose adjustment of medicinal products that are P-gp substrates, especially medicinal products with a narrow therapeutic index such as digoxin, colchicine and dabigatran etexilate, may be needed when concomitantly administered with CRESEMBA (see section 4.5).
Danish: Der kan være behov for dosejustering af lægemidler, som er P-gp-substrater, især lægemidler med et smalt terapeutisk indeks, for eksempel digoxin, colchicin og dabigatranetexilat, hvis de administreres samtidig med CRESEMBA (se pkt.
English: Colchicine concentrations may increase.
Danish: Koncentrationerne af colchicin kan stige.
English: Isavuconazole is an inducer of CYP2B6.
Danish: Isavuconazol er en induktor af CYP2B6.
English: C] isavuconazonium sulfate in humans, in addition to the active moiety (isavuconazole) and the inactive cleavage product, a number of minor metabolites were identified.
Danish: C] -isavuconazoniumsulfat til mennesker blev der identificeret et antal mindre metabolitter udover den aktive del (isavuconazol) og det inaktive spaltningsprodukt.
English: Statins concentrations may increase.
Danish: Koncentrationerne af statinet kan stige.
English: Isavuconazole did not affect the fertility of male or female rats treated with oral doses up to 90 mg/kg/day (2.3-fold the clinical maintenance dose based on mg/m2/day comparisons).
Danish: Isavuconazol påvirkede ikke fertiliteten hos hun- eller hanrotter, der blev behandlet med orale doser på op til 90 mg/kg/dag (2,3 gange den kliniske vedligeholdelsesdosis baseret på sammenligninger med mg/m2/dag).
English: Saquinavir concentrations may decrease (as observed with lopinavir/ritonavir) or increase (CYP3A4 inhibition).
Danish: Koncentrationerne af saquinavir kan falde (som det er set med lopinavir/ritonavir) eller stige (CYP3A4-hæmning).
English: In an open-label non-controlled study, 37 patients with proven or probable mucormycosis received isavuconazole at the same dose regimen as that used to treat invasive aspergillosis.
Danish: I et åbent, ukontrolleret studie fik 37 patienter med påvist eller sandsynlig mucormycose isavuconazol i samme doseringsregimen som det, der blev brugt til behandling af invasiv aspergillose.
English: Midazolam: careful monitoring of clinical signs and symptoms recommended, and dose reduction if required.
Danish: Midazolam: Nøje monitorering af kliniske tegn og symptomer anbefales og justering af dosis om nødvendigt.
English: Natural products Caffeine (CYP1A2 substrate)
Danish: Naturlige produkter Koffein (CYP1A2-substrat)
English: The use of the CYP2B6 substrate efavirenz with CRESEMBA is contraindicated because efavirenz is a moderate inducer of CYP3A4/5 (see section 4.3).
Danish: Anvendelse af CYP2B6-substratet efavirenz sammen med CRESEMBA er kontraindiceret, da efavirenz er en moderat induktor af CYP3A4/5 (se pkt.
English: Hypersensitivity to isavuconazole may result in adverse reactions that include: hypotension, respiratory failure, dyspnoea, drug eruption, pruritus, and rash.
Danish: Overfølsomhed over for isavuconazol kan medføre bivirkninger, som omfatter: hypotension, respirationsinsufficiens, dyspnø, udbrud i huden, pruritus og udslæt.
English: For the strong CYP3A4 inhibitor lopinavir/ritonavir, a two-fold increase in isavuconazole exposure was observed.
Danish: For den potente CYP3A4-hæmmer lopinavir/ritonavir blev der observeret en fordobling i eksponeringen af isavuconazol.
English: You will be given this dose until your doctor tells you otherwise.
Danish: Du vil få denne dosis, indtil din læge siger andet.
English: The infusion must be administered via an infusion set with an in-line filter with a microporous membrane made of polyethersulfone (PES) and with a pore size of 0.2 μm to 1.2 μm.
Danish: Infusionen skal indgives via et infusionssæt med et integreret filter med en mikroporøs membran af polyethersulfon (PES) og en porestørrelse på 0,2 μm til 1,2 μm.
English: Co-administered medicinal product by therapeutic area
Danish: Samtidigt administrerede lægemidler inddelt efter terapeutisk område
English: Short-acting opiate concentrations may increase.
Danish: Koncentrationerne af de korttidsvirkende opiater kan stige.
English: Elevated liver transaminases have been reported in clinical studies (see section 4.8).
Danish: Der er indberettet forhøjede levertransaminaser fra kliniske studier (se pkt.
English: Ciclosporin, sirolimus, tacrolimus: monitoring of plasma levels and appropriate dose adjustment if required.
Danish: Ciclosporin, sirolimus, tacrolimus: monitorering af plasmaniveauer og om nødvendigt relevant dosisjustering.
English: Isavuconazole:
Danish: Isavuconazol:
English: No dose adjustment is required in patients with mild to moderate hepatic impairment.
Danish: Justering af dosis er ikke nødvendig til patienter med mild til moderat nedsat leverfunktion.
English: Isavuconazole is not readily dialysable (see section 4.2).
Danish: Isavuconazol er ikke umiddelbart dialyserbart (se pkt.
English: The concomitant administration of CRESEMBA and carbamazepine, phenytoin and long-acting barbiturates such as phenobarbital is contraindicated.
Danish: Samtidig administration af CRESEMBA og carbamazepin, phenytoin og langtidsvirkende barbiturater, fx phenobarbital, er kontraindiceret.
English: What Cresemba is Cresemba is an anti-fungal medicine that contains the active substance isavuconazole.
Danish: Cresemba er et svampedræbende lægemiddel, der indeholder det aktive stof isavuconazol.
English: The solution for infusion must be administered via an infusion set with an in-line filter (pore size 0.2 μm to 1.2 μm) made of polyether sulfone (PES).
Danish: Infusionsvæsken skal administreres via et infusionssæt med et rækkefilter (porestørrelse 0,2 μm til 1,2 μm), der er fremstillet af polyethersulfon (PES).
English: Dextrorphan (active metabolite): AUCinf: ↑ 4%
Danish: Dextrorphan (aktiv metabolit): AUCinf: ↑ 4%
English: See sections 4.2 and 4.4.
Danish: 4.2 og 4.4.
English: What Cresemba contains - The active substance is isavuconazole.
Danish: Cresemba indeholder - Aktivt stof: isavuconazol.
English: (OCT2 inhibition)
Danish: (OCT2-hæmning)
English: Starting dose for the first two days (48 hours) The recommended dose is two capsules three times a day (every 8 hours).
Danish: Startdosis i de første to dage (48 timer) Den anbefalede dosis er to kapsler tre gang om dagen (hver 8. time).
English: Your doctor should monitor you for possible side effects
Danish: Din læge vil holde øje med, om du får nogen bivirkninger
English: Changes in your liver function
Danish: Ændringer i leverfunktion
English: CYP2B6 substrates
Danish: CYP2B6-substrater
English: Isavuconazole is an inhibitor in vitro of BCRP, and plasma concentrations of substrates of BCRP may therefore be increased.
Danish: Isavuconazol er en hæmmer in vitro af BCRP, og plasmakoncentrationerne af substrater af BCRP kan derfor stige.
English: Other side effects Tell your doctor, pharmacist or nurse if you notice any of the following side effects:
Danish: Fortæl det til lægen, apotekspersonalet eller sundhedspersonalet, hvis du bemærker en eller flere af følgende bivirkninger:
English: The European Medicines Agency has deferred the obligation to submit the results of studies with CRESEMBA in one or more subsets of the paediatric population in the treatment of invasive aspergillosis and the treatment of mucormycosis (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har udsat kravet om at indsende resultaterne af forsøg med CRESEMBA i et eller flere delsæt af den pædiatriske population med invasiv aspergillose og mucormycose (se pkt.
English: • At the request of the European Medicines Agency; • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Danish: • på anmodning fra Det Europæiske Lægemiddelagentur • når risikostyringssystemet ændres, særlig som følge af, at der er modtaget nye oplysninger,
English: Isavuconazole is not removed by haemodialysis.
Danish: Isavuconazol fjernes ikke ved hæmodialyse.
English: Ethinyl oestradiol and norethindrone: no dose adjustment required.
Danish: Ethinyløstradiol og norethindron: intet behov for justering af dosis.
English: Vinca alkaloids (vincristine, vinblastine) (P-gp substrates)
Danish: Vinkaalkaloider (vincristin, vinblastin) (P-gp-substrater)
English: IV use after reconsitution and dilution
Danish: anvendelse efter rekonstitution og fortynding
English: Dextromethorphan: no dose adjustment required.
Danish: Dextromethorphan: Justering af dosis ikke nødvendig.
English: Uridine diphosphate-glucuronosyltransferases (UGT) substrates
Danish: Substrater af uridin-diphosphat-glucuronosyltransferaser (UGT)
English: - The other ingredients (excipients) are mannitol (E421) and sulfuric acid.
Danish: - Øvrige indholdsstoffer: mannitol (E 421) og svovlsyre.
English: Other anticancer agents (daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantrone, topotecan) (BCRP substrates)
Danish: Andre cancermidler (daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantron, topotecan) (BCRP-substrater)
English: Cyclophosphamide concentrations may decrease.
Danish: Koncentrationerne af cyclophosphamid kan falde.
English: Daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantrone or topotecan: careful monitoring for any occurrence of drug toxicity, and dose reduction if required.
Danish: Daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantron eller topotecan: nøje monitorering for forekomst af eventuel lægemiddeltoksicitet og om nødvendigt reduktion af dosis.
English: Swedish Orange (reddish-brown) capsule body marked with ”100” in black ink and a white cap marked with "C" in black ink.
Danish: Rødbrun kapselyderside mærket ”100” i sort farve og en hvid hætte mærket "C" i sort farve.
English: Methadone (CYP3A4/5, 2B6 and 2C9 substrate)
Danish: Methadon (CYP3A4/5-, 2B6- og 2C9substrat)
English: Co-administration of CRESEMBA with medicinal products which are substrates of OCT2 may result in increased plasma concentrations of these medicinal products.
Danish: Samtidig administration af CRESEMBA og lægemidler, som er substrater af OCT2, kan medføre forhøjede plasmakoncentrationer af disse lægemidler.