FrancophonIA/ELRC3.0 huggingface dataset:
English: What Cymevene looks like and contents of the pack Cymevene is a white to off white powder for concentrate for solution for infusion, supplied in a singledose glass vial, with a rubber stopper and aluminium closure with flip-off cap.
Danish: Cymevene er et hvidt til råhvidt pulver til koncentrat til infusionsvæske, der leveres i enkeltdosishætteglas af glas med gummiprop og aluminiumshætte, der kan vippes af.
English: Based on the occurrence of aspermatogenesis at ganciclovir exposures below therapeutic levels in animal studies, it is considered likely that ganciclovir may cause temporary or permanent inhibition of human spermatogenesis (see section 4.4).
Danish: Da der i dyrestudier er set tilfælde af aspermatogenese ved ganciclovirniveauer under det terapeutiske niveau, vurderes det som sandsynligt, at ganciclovir kan forårsage midlertidig eller permanent hæmning af den humane spermatogenese (se pkt.
English: • a skin reaction where the medicine was injected - such as inflammation, pain and swelling.
Danish: • reaktion i huden, hvor medicinen er givet, for eksempel rødme, smerter og hævelse.
English: Mean Ganciclovir systemic plasma clearance (mL/min)
Danish: Gennemsnitlig systemisk plasmaclearance af ganciclovir (ml/min)
English: If the blood cell counts are significantly reduced during therapy with ganciclovir, treatment with haematopoietic growth factors and/or discontinuation of treatment should be considered (see sections 4.4 and 4.8).
Danish: Hvis antallet af blodceller falder betydeligt under behandlingen med ganciclovir, bør behandling med hæmatopoietiske vækstfaktorer og/eller seponering af ganciclovir overvejes (se pkt.
English: Patients with renal impairment have an increased elimination half-life and, depending on renal function, it ranges from about 6 to 17 hours (see section 4.2 for dose modifications required in patients with renal impairment).
Danish: Patienter med nedsat nyrefuntion har forlænget eliminationshalveringstid, der afhængigt af nyrefunktionen spænder fra ca. 6 til 17 timer (se pkt.
English: Haemodialysis reduces plasma concentrations of ganciclovir by about 50% after intravenous administration during a 4-hour haemodialysis session.
Danish: I løbet af en 4-timers hæmodialyse-session reduceres plasmakoncentrationen af ganciclovir efter intravenøs administration med ca. 50%.
English: The duration of maintenance therapy is based on the risk of CMV disease, local treatment guidelines should be consulted.
Danish: Varigheden af vedligeholdelsesbehandlingen skal baseres på risikoen for CMV-infektion og i overensstemmelse med lokale vejledninger.
English: • allergic reaction - the signs may include, red itchy skin, swelling of the throat, face, lips or mouth, difficulty swallowing or breathing.
Danish: • allergisk reaktion - tegn på dette kan være rødme og kløe på huden, hævet svælg, ansigt, læber eller mund, synkebesvær eller vejrtrækningsbesvær.
English: Following reconstitution of the powder, 1ml solution contains 50 mg ganciclovir.
Danish: Efter rekonstitution af pulveret indeholder 1 ml koncentrat 50 mg ganciclovir.
English: • hives, dry skin
Danish: • nældefeber, tør hud
English: • hydroxyurea - used for a problem called polycythemia, sickle cell disease and cancer,
Danish: • hydroxyurinstof - anvendes til behandling af polycytæmi, seglcelleanæmi og kræft
English: Tell your doctor straight away if you notice any of the side effects above.
Danish: Kontakt straks lægen, hvis du oplever én eller flere af ovenstående bivirkninger.
English: In animals studies ganciclovir was associated with reproductive toxicity and teratogenicity (see sections 4.4 and 5.3).
Danish: I dyrestudier har ganciclovir været forbundet med reproduktionstoksicitet og teratogenicitet (se pkt.
English: • muscle pain or spasms
Danish: • muskelsmerter eller -kramper
English: After reconstitution Cymevene is a colourless to slightly yellowish solution, practically free from visible particles.
Danish: Efter rekonstitution er Cymevene en farveløs til let gullig opløsning stort set uden synlige partikler.
English: Cymevene should be administered as recommended in section 4.2 to reduce the risk of local tissue irritation.
Danish: 4.2 med henblik på at minimere risikoen for lokal vævsirritation.
English: If you are a woman who could get pregnant - use contraception while you are using Cymevene.
Danish: Hvis du kan blive gravid, skal du bruge prævention, mens du er i behandling med Cymevene.
English: OTHER SPECIAL WARNING(S), IF NECESSARY Avoid direct contact with or inhalation of the powder contained in the vial or direct contact of the solution with skin or mucous membranes.
Danish: EVENTUELLE ANDRE SÆRLIGE ADVARSLER Undgå at inhalere eller have direkte kontakt med pulveret i hætteglasset og undgå, at hud og slimhinder kommer i direkte kontakt med koncentratet/infusionsvæsken.
English: The duration of prophylaxis is based on the risk of CMV disease, local treatment guidelines should be consulted.
Danish: Varigheden af den profylaktiske behandling skal baseres på risikoen for CMV-infektion og i overensstemmelse med lokale vejledninger.
English: For storage conditions of the reconstituted concentrate, see sections 6.3.
Danish: 6.3 vedrørende opbevaringsbetingelser for det rekonstituerede koncentrat.
English: Alopecia Urticaria Dry skin
Danish: Alopeci Urticaria Tør hud
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each vial contains ganciclovir sodium equivalent to 500 mg ganciclovir
Danish: ANGIVELSE AF AKTIVT STOF Hvert hætteglas indeholder ganciclovirnatrium svarende til 500 mg ganciclovir
English: Very common: may affect more than 1 in 10 people
Danish: Meget almindelig: kan påvirke flere end 1 ud af 10 patienter
English: This is because Cymevene may pass into breast milk.
Danish: Det er vigtigt, fordi mælken kan indeholde Cymevene.
English: If your doctor wants you to start using Cymevene you must stop breast-feeding before you start using the medicine.
Danish: Hvis du skal have Cymevene, skal du holde op med at amme, inden du begynder behandlingen.
English: Please refer to the Summary of Product Characteristics for full prescribing information.
Danish: INSTRUKTIONER FOR ANVENDELSE OG HÅNDTERING Se produktresumé for fuldstændig information.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT
Danish: INDHOLD ANGIVET SOM VÆGT, VOLUMEN ELLER ANTAL DOSER 500 mg
English: Cytochrome P450 isoenzymes play no role in ganciclovir pharmacokinetics.
Danish: CYP-isoenzymer har ingen indvirkning på ganciclovirs farmakokinetik.
English: • eczema, skin problems, itching
Danish: • eksem, hudproblemer, kløe
English: Men must be advised to practice barrier contraception during treatment, and for at least 90 days thereafter, unless it is certain that the female partner is not at risk of pregnancy (see sections 4.6, 4.8 and 5.3).
Danish: Mænd skal informeres om at anvende barriere-prævention under behandlingen og i mindst 90 dage efter, behandlingen er afsluttet, medmindre det er absolut sikkert, at en kvindelig partner ikke risikerer graviditet (se pkt.
English: Do not administer by rapid or bolus intravenous injection because the resulting excessive plasma levels may increase the toxicity of ganciclovir.
Danish: Må ikke gives hurtigt eller som intravenøs bolusinjektion, da dette kan medføre meget høje plasmaværdier, der kan øge ganciclovirs toksicitet.
English: Available in packs of 1 vial or 5 vials.
Danish: Fås i pakninger med 1 eller 5 hætteglas.
English: Ganciclovir was mutagenic in mouse lymphoma cells and clastogenic in mammalian cells.
Danish: Ganciclovir er mutagent i muselymfomceller og klastogent i pattedyreller.
English: If you are planning to have a baby, talk to your doctor or pharmacist before using Cymevene.
Danish: Hvis du planlægger at få børn, skal du tale med lægen, inden du får Cymevene.
English: Dosage reduction is required (see sections 4.2 and 5.2).
Danish: 4.2 og 5.2).
English: No studies on the efficacy or safety of ganciclovir in the elderly have been conducted.
Danish: Ganciclovirs virkning og sikkerhed er ikke undersøgt hos ældre patienter.
English: <To be completed nationally]
Danish: <[Udfyldes nationalt]>
English: {(Invented) name and associated names (see Annex I) strength pharmaceutical form} [See Annex I - To be completed nationally]
Danish: {Cymevene og relaterede navne (see bilag I) styrke, lægemiddelform} [Se bilag I - udfyldes nationelt]
English: Hypersensitivity to the active substance or valganciclovir or to any of the excipients listed in section
Danish: Overfølsomhed over for den aktive substans eller valganciclovir eller et eller flere af hjælpestofferne angivet i pkt.
English: • changes in blood cell counts
Danish: • ændringer i blodtallene
English: Do not use Cymevene if you are breast-feeding.
Danish: Du må ikke få Cymevene, hvis du ammer.
English: Avoid inhalation or direct contact of the powder contained in the vials or direct contact of the reconstituted solution with the skin or mucous membranes.
Danish: Undgå at inhalere eller have direkte kontakt med pulveret i hætteglassene og undgå, at hud og slimhinder kommer i direkte kontakt med det rekonstituerede koncentrat.
English: Rare: may affect up to 1 in 1,000 people
Danish: Sjælden: kan påvirke op til 1 ud af 1000 patienter
English: Abdominal distention Mouth ulceration Pancreatitis
Danish: Abdominal udspiling Sår i munden Pankreatitis
English: Each glass vial contains 500 mg ganciclovir as ganciclovir sodium.
Danish: Hvert hætteglas indeholder 500 mg ganciclovir som ganciclovirnatrium.
English: Treatment of CMV disease in adults and adolescents from 12 years of age with normal renal function
Danish: Profylaktisk eller præventiv behandling til forebyggelse af CMV-infektion hos voksne og unge over 12 år med normal nyrefunktion
English: Rare (≥ 1/10000, < 1/1000)
Danish: Sjælden (≥ 1/10.000 til < 1/1.000)
English: For patients with renal impairment, the dose of ganciclovir should be modified according to creatinine clearance as shown in the table below (see sections 4.4 and 5.2).
Danish: Hos patienter med nedsat nyrefunktion bør ganciclovirdosis justeres i henhold til creatininclearance (CrCl), som angivet i nedenstående tabel (se pkt.
English: Check with your doctor or pharmacist if you are not sure.
Danish: Spørg lægen, apotekspersonalet eller sundhedspersonalet, hvis der er noget du er i tvivl om.
English: Since renal function decreases with age, ganciclovir should be administered to the elderly with special consideration for their renal status (see section 4.2).
Danish: Da nyrefunktionen falder med alderen, skal der tages særligt hensyn til denne, når ganciclovir administreres til ældre patienter (se pkt.
English: • stomach pain, constipation, wind, indigestion
Danish: • mavesmerter, forstoppelse, luft fra tarmen, fordøjelsesbesvær
English: Excipient(s) with known effect: approximately 43 mg (2 mEq) sodium.
Danish: Hjælpestof, som behandleren skal være opmærksom på: ca. 43 mg (2 mmol) natrium.
English: Therefore, these drugs should be considered for concomitant use with ganciclovir only if the potential benefits outweigh the potential risks (see section 4.4).
Danish: Samtidig administration af disse lægemidler og ganciclovir bør derfor kun overvejes, hvis de potentielle fordele opvejer de potentielle risici (se pkt.
English: Preparation of final diluted solution for infusion
Danish: Fremstilling af færdig fortyndet infusionsvæske:
English: Also do this for at least 90 days after Cymevene has been stopped.
Danish: Du skal fortsætte med at bruge prævention i form af en barrieremetode i mindst 90 dage, efter du er holdt op med at få Cymevene.
English: If you are not sure, talk to your doctor, pharmacist or nurse before using Cymevene.
Danish: Hvis du er i tvivl, skal du kontakte lægen, apotekspersonalet eller sundhedspersonalet, før du får Cymevene.
English: • low white blood cell counts - with signs of infection such as sore throat, mouth ulcers or a fever
Danish: • lavt antal hvide blodlegemer - med tegn på infektion, for eksempel ondt i halsen, sår i munden eller feber
English: • feeling tired, dizzy, weak or generally unwell
Danish: • træthed, svimmelhed, svaghed eller almindelig utilpashed
English: You may get the following symptoms if you have too much:
Danish: Hvis du har fået for meget, kan du opleve følgende:
English: Convulsions have been reported in patients taking imipenem-cilastatin and ganciclovir.
Danish: Der er rapporteret kramper hos patienter behandlet med imipenem-cilastatin og ganciclovir.
English: Mycophenolate mofetil, stavudine, trimethoprim and zidovudine No significant pharmacokinetic interactions were observed when ganciclovir was administered in combination with either: mycophenolate mofetil, stavudine, trimethoprim or zidovudine.
Danish: Der er ikke set signifikante farmakokinetiske interaktioner, når ganciclovir administreres i kombination med mycofenolatmofetil, stavudin, trimethoprim eller zidovudin.
English: Didanosine
Danish: Didanosin
English: • low level of platelets - signs include bleeding or bruising more easily than usual, blood in urine or stools or bleeding from gums, the bleeding could be severe.
Danish: • lavt antal blodplader - tegn på dette kan være, at du bløder mere eller lettere får blå mærker, har blod i urinen eller afføringen eller bløder fra tandkødet.
English: Ganciclovir may have a major influence on the ability to drive and use machines (see section 4.8).
Danish: 4.7 Virkninger på evnen til at føre motorkøretøj og betjene maskiner Gancliclovir kan i høj grad påvirke evnen til at føre motorkøretøj og betjene maskiner (se pkt.
English: It is considered likely that ganciclovir causes temporary or permanent inhibition of spermatogenesis (see sections 4.6, 4.8 and 5.3).
Danish: Det anses som sandsynligt, at ganciclovir forårsager midlertidig eller permanent hæmning af spermatogenesen (se pkt.
English: If any of the above apply to you (or you are not sure), talk to your doctor, pharmacist or nurse before using Cymevene.
Danish: Hvis ét eller flere af disse punkter passer på dig (eller hvis du er usikker), skal du sige det til lægen, apotekspersonalet eller sundhedspersonalet, inden du får Cymevene.
English: Confusional state Thinking abnormal
Danish: Abnorme tanker Agitation
English: • bacterial skin infection - signs include red, painful or swollen skin
Danish: • bakterieinfektion i huden - tegn på dette kan være rødme, smerte og hævelse i huden
English: Reconstituted solutions of Cymevene range in colour from colourless to light yellow.
Danish: Rekonstitueret Cymevene-koncentrat kan variere i farve, fra farveløs til lysegul.
English: • tremor, shaking
Danish: • skælven, rysten
English: Induction therapy: 5 mg/kg given as an intravenous infusion over one hour, every 12 hours for 7 - 14 days.
Danish: Initialbehandling: 5 mg/kg som intravenøs infusion over 1 time hver 12. time i 7-14 dage.
English: Respiratory, thoracic and mediastinal disorders: Very common (≥ 1/10):
Danish: Luftveje, thorax og mediastinum: Meget almindelig (≥ 1/10):
English: If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before using Cymevene.
Danish: Hvis du tager et eller flere af disse lægemidler (eller hvis du er usikker), skal du sige det til lægen eller apotekspersonalet, inden du får Cymevene.
English: Agitation Psychotic disorder
Danish: Psykotiske forstyrrelser Hallucinationer*
English: 0.625 mg/kg/day
Danish: 0,625 mg/kg/dag
English: 5 mg/kg given as an intravenous infusion over one hour, once daily on 7 days per week or 6 mg/kg once daily on 5 days per week.
Danish: 5 mg/kg som intravenøs infusion over 1 time 1 gang dagligt 7 dage om ugen eller 6 mg/kg 1 gang dagligt 5 dage om ugen.
English: Using this medicine
Danish: Brug af lægemidlet
English: While you are using Cymevene your doctor will do regular blood tests.
Danish: Lægen vil jævnligt tage blodprøver, mens du er i behandling med Cymevene.
English: 0.625 mg/kg 3x/wk after haemodialysis
Danish: 0,625 mg/kg 3 gange om ugen efter hæmodialyse
English: The majority of the reports were either not associated with any adverse reactions, or included one or more of the adverse reactions listed below: - Haematological toxicity: myelosuppression including pancytopenia, medullary aplasia, leucopenia, neutropenia, granulocytopenia - Hepatotoxicity: hepatitis, liver function disorder - Renal toxicity: worsening of haematuria in a patient with pre-existing renal impairment, acute renal failure, elevated creatinine.
Danish: neutropeni, granulocytopeni - Levertoksicitet: hepatitis, leverfunktionsforstyrrelser - Nyretoksicitet: forværring af hæmaturi hos en patient med allerede eksisterende nedsat nyrefunktion, akut nyresvigt, forhøjet creatinin.
English: Cardiac arrhythmias
Danish: Artralgi Muskelspasmer
English: Creatinine clearance renal decreased Renal impairment
Danish: Nedsat renal creatininclearance Nedsat nyrefunktion Forhøjet blod-creatinin
English: Macular oedema Retinal detachment Vitreous floaters Eye pain
Danish: Makulaødem Nethindeløsning Mouches volantes Øjensmerter
English: Maintenance therapy: 5 mg/kg given as an intravenous infusion over one hour, once daily on 7 days per week or 6 mg/kg once daily on 5 days per week.
Danish: Vedligeholdelsesbehandling: 5 mg/kg som intravenøs infusion over 1 time 1 gang dagligt 7 dage om ugen eller 6 mg/kg 1 gang dagligt 5 dage om ugen.
English: The diluted solution should then be infused intravenously over 1 hour as directed in section 4.2.
Danish: Den fortyndede infusionsvæske infunderes intravenøst over 1 time, som beskrevet i pkt.
English: The use of ganciclovir warrants extreme caution, especially in the paediatric population due to the potential for long-term carcinogenicity and reproductive toxicity.
Danish: På grund af langtidsrisiko for karcinogenicitet og reproduktionstoksicitet er ekstrem forsigtighed nødvendig ved brug af ganciclovir specielt til den pædiatriske population.
English: Renal impairment: It is expected that an overdose of ganciclovir could result in increased renal toxicity in patients with renal impairment (see section 4.4).
Danish: Yderligere information vedrørende særlige populationer Patienter med nedsat nyrefunktion: Det forventes, at overdosering af ganciclovir kan medføre øget nyretoksicitet hos patienter med nedsat nyrefunktion (se pkt.
English: What you need to know before you use Cymevene
Danish: Det skal du vide, før du begynder at få Cymevene Sådan får du Cymevene
English: Use with other medicines
Danish: Samtidig administration af andre lægemidler
English: For storage conditions of the diluted solution for infusion, see section 6.3.
Danish: 6.3 vedrørende opbevaringsbetingelser for den fortyndede infusionsvæske.
English: Powder for concentrate for solution for infusion (powder for concentrate).
Danish: Pulver til koncentrat til infusionsvæske, opløsning (pulver til koncentrat) Hvidt til grålighvidt pulver.
English: • shaking or fits
Danish: • rysten eller kramper
English: Reproductive system and breast disorders: Uncommon (≥ 1/1000, < 1/100):
Danish: Det reproduktive system og mammae: Ikke almindelig(≥ 1/1.000 til < 1/100):
English: Metabolic and nutrition disorders: Common (≥ 1/100, < 1/10):
Danish: Metabolisme og ernæring: Almindelig (≥ 1/100 til < 1/10):
English: This is because Cymevene may harm the unborn baby.
Danish: Det skyldes, at Cymevene kan skade fostret.
English: The flip-off cap should be removed to expose the central portions of the rubber stopper.
Danish: Vip hætten af, så gummiproppen blottes.
English: Cymevene is a powder for solution for infusion.
Danish: Cymevene er pulver til koncentrat til infusionsvæske, opløsning.
English: In animal studies ganciclovir impaired fertility in male and female mice.
Danish: I dyrestudier har ganciclovir forårsaget nedsat fertilitet hos han- og hunmus.
English: • stomach pain, diarrohea or being sick
Danish: • ondt i maven, diarré eller opkastning
English: Information on the safety and efficacy of ganciclovir in children under 12 years of age, including neonates, is limited (see sections 4.4, 4.8 and 5.1).
Danish: Der foreligger kun begrænset information om ganciclovirs virkning og sikkerhed hos børn under 12 år, inklusive nyfødte (se pkt.
English: • feeling short of breath.
Danish: • åndenød.
English: 1.25 mg/kg/day
Danish: 1,25 mg/kg/dag
English: Convulsions have been reported in patients taking ganciclovir and imipenem−cilastatin concomitantly.
Danish: Der har været rapporter om kramper hos patienter behandlet med imipenem-cilastatin og ganciclovir samtidigt.
English: This includes the retina at the back of the eye - this means the virus can cause problems with eye sight.
Danish: Derfor kan dette virus give problemer med synet.
English: Common (≥ 1/100, < 1/10):
Danish: Almindelig (≥ 1/100 til < 1/10):
English: Nervous system disorders: Common (≥ 1/100, < 1/10):
Danish: Nervesystemet: Almindelig (≥ 1/100 til < 1/10):
English: Convulsions have been reported in patients taking imipenem-cilastatin and ganciclovir (see sections 4.4 and 4.5).
Danish: Der er rapporteret kramper hos patienter behandlet med imipenem-cilastatin og ganciclovir (se pkt.
English: Gastrointestinal disorders: Very common (≥ 1/10):
Danish: Mave-tarmkanalen: Meget almindelig (≥ 1/10):
English: How to store Cymevene
Danish: Sådan får du Cymevene
English: Haematuria Renal failure
Danish: Hæmaturi Nyresvigt
English: If you use more Cymevene than you should
Danish: Hvis du har fået for meget Cymevene
English: • changes to your sense of touch, tingling, tickling, pricking or burning feeling
Danish: • føleforstyrrelser eller prikkende/kildende/brændende fornemmelse i huden
English: Patients with Renal Impairment Undergoing Haemodialysis
Danish: Patienter med nedsat nyrefunktion i hæmodialyse
English: 25-49 mL/min 2.5 mg/kg/day
Danish: 25-49 ml/min
English: Cymevene and associated names (see Annex I) 500 mg powder for concentrate for solution for infusion
Danish: Indlægsseddel: Information til brugeren Cymevene og relaterede navne (se bilag I) 500 mg pulver til koncentrat til infusionsvæske, opløsning (Se bilag I - Udfyldes nationalt ) ganciclovir
English: Immune system disorders: Uncommon (≥ 1/1000, < 1/100):
Danish: Immunsystemet: Ikke almindelig (≥ 1/1.000 til < 1/100):
English: Skin and subcutaneous tissues disorders: Common (≥ 1/100, < 1/10):
Danish: Hud og subkutane væv: Almindelig (≥ 1/100 til < 1/10):
English: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products except those mentioned in section 6.6.. Do not use bacteriostatic water for injections containing parabens (para-hydroxybenzoates) since these are incompatible with Cymevene and may cause precipitation.
Danish: Der må ikke anvendes bakteriostatisk vand til injektionsvæsker indeholdende parabener (parahydroxybenzoater), da disse er uforligelige med Cymevene og kan forårsage udfældning.
English: Do not administer by intramuscular or subcutaneous injection because this may result in severe tissue irritation due to the high pH (~11) of ganciclovir solution.
Danish: Må ikke administreres intramuskulært eller subkutant, da ganciclovir-infusionsvæskens høje pH (~11) kan forårsage svær vævsirritation.
English: The corresponding values of mean systemic clearance, mean renal clearance, and mean elimination half-life were 4.66 ± 1.72 mL/min/kg, 3.49 ± 2.40 mL/min/kg, and 2.49 ± 0.57 h, respectively.
Danish: De tilsvarende værdier for gennemsnitlig systemisk clearance, gennemsnitlig renal clearance og gennemsnitlig halveringstid var henholdsvis 4,66 ± 1,72 ml/min/kg; 3,49 ± 2,40 ml/min/kg og 2,49 ± 0,57 t. De farmakokinetiske data for intravenøs ganciclovir hos spædbørn og børn svarede til dem, der sås hos nyfødte og voksne.
English: Renal and urinary disorders: Common (≥ 1/100, < 1/10):
Danish: Nyrer og urinveje: Almindelig (≥ 1/100 til < 1/10):
English: Psychiatric disorders: Common (≥ 1/100, < 1/10):
Danish: Psykiske forstyrrelser: Almindelig (≥ 1/100 til < 1/10):
English: ganciclovir, some with fatal outcomes, have been received from clinical trials and during post-marketing experience.
Danish: Der har i kliniske forsøg samt efter markedsføring været rapporter om overdosering med intravenøs ganciclovir, nogle med dødeligt udfald.