FrancophonIA/ELRC3.0 huggingface dataset:
English: Multiple, time-matched ECGs collected over a 12 hour period were obtained before and during administration of posaconazole oral suspension (400 mg twice daily with high fat meals) from 173 healthy male and female volunteers aged 18 to 85 years.
Danish: Fra 173 raske mandlige og kvindelige forsøgspersoner i alderen 18til85 år blev der før og under administration af posaconazol oral suspension (400 mg to gange dagligt med et fedtrigt måltid)indsamletfleretidsmæssigtsammenligneligeekg'eroverenperiodepå12 timer.
English: If you develop severe diarrhoea or vomiting (being sick) while taking Posaconazole Accord, talk to your doctor, pharmacist or nurse straight away, as this may stop it from working properly.
Danish: Tal straks med lægen, apotekspersonalet eller sundhedspersonalet, hvis du får alvorlig diarré eller kaster op, mens du tager Posaconazole Accord, da dette kan medføre, at det ikke virker ordentligt.
English: back pain, neck pain, musculoskeletal pain, pain in extremity
Danish: Rygsmerter, nakkesmerter, muskuloskeletale smerter, ekstremitetssmerter
English: Eye disorders Uncommon:
Danish: Øjne Ikke almindelig
English: Prophylaxis in AML and HSCT Study 5615
Danish: ProfylakseforAML og HSCT
English: 6.6 Special precautions for disposal
Danish: 6.6 Reglerforbortskaffelse
English: pulmonary embolism, deep vein thrombosis Respiratory, thoracic and mediastinal disorders Uncommon:
Danish: Luftveje, thorax og mediastinum Ikke almindelig
English: The use of combination antifungal therapies should not decrease the efficacy of either posaconazole or the other therapies; however, there is currently no clinical evidence that combination therapy will provide an added benefit.
Danish: Kombinationsbehandling med antimykotika bør ikke nedsætte virkningen af hverken posaconazol eller de andre lægemidler.
English: There is no paediatric experience for posaconazole tablets.
Danish: Pædiatrisk population Der foreligger ingen erfaring med posaconazol-tabletter til børn.
English: Fusarium spp.
Danish: Fusarium-arter
English: Table 4.
Danish: Tabel4.
English: Treatment with these HMG-CoA reductase inhibitors should be discontinued during treatment with posaconazole as increased levels have been associated with rhabdomyolysis (see section 4.3).
Danish: HMG-CoA reduktasehæmmere metaboliseret via CYP3A4 (f.eks. simvastatin, lovastatin ogatorvastatin) PosaconazolkanøgeplasmaniveauerneafHMG-CoA reduktasehæmmere, som metaboliseres afCYP3A4,betydeligt.BehandlingmeddisseHMG-CoAreduktasehæmmere bør seponeres underbehandling med posaconazol, da forhøjede niveauer har været forbundet med rhabdomyolyse (sepkt.
English: hepatic failure, hepatitis cholestatic, hepatosplenomegaly, liver tenderness, asterixis Skin and subcutaneous tissue disorders Common:
Danish: Nedsat leverfunktion, kolestatisk hepatitis, hepatosplenomegali, leverømhed, asterixis
English: Always take this medicine exactly as your doctor or pharmacist has told you.
Danish: Tag altid lægemidletnøjagtigt efter lægens ellerapotekspersonalets anvisning.Erdu i tvivl,såspørglægen eller apotekspersonalet.
English: Rifamycin antibacterials (rifampicin, rifabutin), certain anticonvulsants (phenytoin, carbamazepine, phenobarbital, primidone), and efavirenz
Danish: Rifamycin antibakterielle midler (rifampicin, rifabutin), visse antiepileptika (phenytoin,carbamazepin, phenobarbital, primidon) og efavirenz Koncentrationenafposaconazolkanværebetydeligtnedsatvedkombination.Samtidigbehandlingmed posaconazol bør derfor undgås, medmindre fordelen for patienten opvejer risikoen (se pkt.4.5).
English: oedema, pain, chills, malaise, chest discomfort, drug intolerance, feeling jittery, mucosal inflammation
Danish: Ødem, smerte, kuldegysninger, utilpashed, ubehag i brystet, lægemiddeloverfølsomhed, rastløshed, slimhindebetændelse
English: Do not throw away any medicines via wastewater or household waste.
Danish: Af hensyn til miljøet må du ikkesmide medicinresteriafløbet,toilettetellerskraldespanden.
English: cough, epistaxis, hiccups, nasal congestion, pleuritic pain, tachypnoea
Danish: Hoste, næseblod, hikke, tilstoppet næse, pleurale smerter, hurtig vejrtrækning
English: Posaconazole plasma concentrations following administration of posaconazole tablets may increase over time in some patients (see section 5.2).
Danish: Plasmakoncentrationen af posaconazolkanmedtidenstigehosnogle patienter, der får posaconazol tabletter (se pkt.
English: gastrointestinal haemorrhage, ileus
Danish: Blødning i mave/tarm, ileus
English: Discontinuation of Posaconazole Accord should be considered if clinical signs and symptoms are consistent with development of liver disease.
Danish: Hvis der er kliniske tegn og symptomer på udvikling af leversygdom, bør seponeringaf Posaconazole Accord overvejes.
English: The mean duration of therapy was 29 days for posaconazole and 25 days for fluconazole/itraconazole.
Danish: NydiagnosticeretAML var denhyppigsteunderliggende sygdom(435/602, [72 %]).Den gennemsnitligebehandlingsvarighed var 29 dageforposaconazolog25 dage forfluconazol/itraconazol.
English: Fixed-time periodc
Danish: • endetarmsgener.
English: Other side effects Tell your doctor, pharmacist or nurse if you notice any of the following side effects:
Danish: - Kontakt lægen, apotekspersonalet eller sundhedspersonalet, hvis du får bivirkninger,
English: Hepatic impairment
Danish: Tungeødem, ansigtsødem
English: The safety of posaconazole tablet has been assessed in 336 patients and healthy volunteers enrolled in clinical trials.
Danish: De hyppigst rapporterede alvorlige bivirkningererkvalme,opkastning,diarré, pyreksi og øgetbilirubinniveau.Sikkerheden af posaconazol tabletter er vurderet hos 336 patienter og raske frivillige forsøgspersoner i kliniske studier.
English: Posaconazole Accord can increase the amount of these medicines in the blood which may lead to very serious changes to your heart rhythm: - any medicines that contain “ergot alkaloids” such as ergotamine or dihydroergotamine used to treat migraines.
Danish: Posaconazole Accord kan anvendes hos voksne til behandling af følgende svampeinfektioner, når andre svampemidlerikkeharvirket,ellerduvarnødt til at stoppe med at tage dem:
English: This medicine can also be used to prevent fungal infections in adults who are at high risk of getting a fungal infection, such as: - patients who have a weak immune system due to having chemotherapy for “acute myelogenous leukemia” (AML) or “myelodysplastic syndromes” (MDS) - patients having “high- dose immunosuppressive therapy” after “hematopoietic stem cell transplant” (HSCT).
Danish: Dette lægemiddel kan også anvendes til at forebygge svampeinfektioner hos voksne,som har en højrisiko for at få en svampeinfektion, f.eks.:
English: What Posaconazole Accord is and what it is used for
Danish: Posaconazole Accord indeholder:
English: - inability to sleep (insomnia) - being completely or partially unable to talk - swelling of the mouth - abnormal dreams, or difficulty sleeping - problems with co-ordination or balance - mucosal inflammation - stuffy nose - difficulty breathing - chest discomfort - feeling bloated - mild to severe nausea, vomiting, cramps and diarrhoea, usually caused by a virus, stomach pain - belching - feeling jittery
Danish: • anæmiogetlavthæmoglobinniveau(fremgårafdineblodprøver) - tegnpådettekanværehovedpine, træthed eller svimmelhed,åndenødellerbleghed
English: − Integrilin is not intended for use in children or adolescents less than 18 years of age.
Danish: - Integrilin er ikke beregnet til anvendelse hos børn eller unge under 18 år.
English: INTEGRILIN should not be used during pregnancy unless clearly necessary.
Danish: INTEGRILIN bør ikke anvendes under graviditet, medmindre det er klart nødvendigt.
English: INTEGRILIN is not compatible with furosemide.
Danish: INTEGRILIN er ikke forligeligt med furosemid.
English: Integrilin is not usually recommended for use during pregnancy.
Danish: Integrilin anbefales normalt ikke til brug under graviditet.
English: 0.034a a: Pearson's chi-square test of difference between placebo and eptifibatide.
Danish: 0,034a a: Pearson's chi-square test af difference mellem placebo og eptifibatid.
English: Incidence of Death/CEC-Assessed MI («Treated as Randomised» Population)
Danish: Hyppigheden af dødsfald/CEC-vurderede MI (“Behandlet som randomiseret” population)
English: The extent of eptifibatide binding to human plasma protein is about 25 %.
Danish: Graden af eptifibatid binding til humant plasmaprotein er omkring 25 %.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent published on the European medicines web-portal.
Danish: Kravene for fremsendelse af periodiske, opdaterede sikkerhedsindberetninger for dette lægemiddel fremgår af listen over EU-referencedatoer (EURD list), som fastsat i artikel 107c, stk. 7, i direktiv 2001/83/EF, og alle efterfølgende opdateringer offentliggjort på den europæiske webportal for lægemidler.
English: − During use of Integrilin, you will be checked carefully for any signs of unusual or unexpected bleeding.
Danish: - Under brugen af Integrilin vil du blive omhyggeligt undersøgt for tegn på usædvanlig eller uventet blødning.
English: INTEGRILIN-treated patients who had a prothrombin time (PT) > 14.5 seconds and received warfarin concomitantly did not appear to be at an increased risk of bleeding.
Danish: INTEGRILIN-behandlede patienter, der havde en protrombintid (PT) > 14,5 sekunder og fik warfarin samtidig, syntes ikke at have øget risiko for blødning.
English: Table 1
Danish: Tabel 1.
English: GUSTO severe/life threatening bleeding was uncommon and comparable in both treatment groups (0.8%).
Danish: GUSTO svær/livstruende blødning var ikke almindelig og sammenlignelig i de to behandlingsgrupper (0,8 %).
English: Your doctor will weigh up the benefit to you against the risk to your baby of using Integrilin while you are pregnant.
Danish: Lægen vil opveje fordelene for dig ved at få Integrilin, mens du er gravid, op mod risikoen for dit ufødte barn.
English: There is no experience with INTEGRILIN and low molecular weight heparins.
Danish: Der er ingen erfaringer med INTEGRILIN og lavmolekylære hepariner.
English: If serious bleeding occurs that is not controllable with pressure, the INTEGRILIN infusion should be stopped immediately and any unfractionated heparin that is given concomitantly.
Danish: Hvis der forekommer alvorlig blødning, der ikke kan kontrolleres med tryk, skal infusionen med INTEGRILIN og eventuel ufraktioneret heparin, der gives samtidig, stoppes øjeblikkeligt.
English: An increased risk of bleeding may also be observed in patients who receive early administration of INTEGRILIN (e.g. upon diagnosis) compared to receiving it immediately prior to PCI, as seen in the Early ACS trial.
Danish: En øget risiko for blødning kan også observeres hos patienter, som får tidlig administration af INTEGRILIN (f.eks. ved diagnosticeringen) sammenlignet med patienter, som får det umiddelbart før PCI, som set i EARLY ACS-forsøget.
English: INTEGRILIN is also intended for concurrent use with acetylsalicylic acid, as it is part of standard management of patients with acute coronary syndromes, unless its use is contraindicated.
Danish: INTEGRILIN er også beregnet til anvendelse samtidig med acetylsalicylsyre, idet dette er en del af standardbehandlingen af patienter med akutte koronarsyndromer, medmindre anvendelse er kontraindiceret.
English: Frequencies are defined as very common (≥1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000).
Danish: Meget almindelig (≥1/10), Almindelig (≥1/100 til <1/10), Ikke almindelig (≥1/1000 til <1/100), Sjælden (≥1/10.000 til <1/1000), Meget sjælden (<1/10.000), Ikke kendt (kan ikke estimeres ud fra tilgængelige data).
English: Thrombocytopaenia occurring after first exposure to a GPIIb/IIIa inhibitor may be explained by the fact that antibodies are naturally present in some normal individuals.
Danish: Trombocytopeni, der opstår efter første eksponering for en GP-IIb/IIIa-hæmmer, kan måske forklares ved det faktum, at antistoffer er naturligt til stede hos nogle normale individer.
English: − Before and during your treatment with Integrilin, samples of your blood will be tested as a safety measure to limit the possibility of unexpected bleeding.
Danish: - Før og under din behandling med Integrilin, vil du få taget blodprøver, der skal undersøges, for at begrænse risikoen for en uventet blødning.
English: In patients undergoing CABG, the incidence of bleeding was not increased by Integrilin compared to the patients treated with placebo.
Danish: Hos patienter, der gennemgik CABG, øgede Integrilin ikke forekomsten af blødninger sammenlignet med patienter behandlet med placebo.
English: The mechanism, whether immune- and/or non-immune-mediated, by which eptifibatide may induce thrombocytopaenia is not fully understood.
Danish: Mekanismen, hvad enten den er immun- og/eller ikke-immunmedieret, hvormed eptifibatid inducerer trombocytopeni, kendes ikke i detaljer.
English: Marketing Authorisation Holder and manufacturer Marketing Authorisation Holder:
Danish: Indehaver af markedsføringstilladelsen og fremstiller Indehaver af markedsføringstilladelsen:
English: Date of latest renewal: 09.07.2009
Danish: Dato for første markedsføringstilladelse: 01.07.1999 Dato for seneste fornyelse: 09.07.2009
English: During treatment with Integrilin in this study, minor bleeding was a very common complication (>1/10, or 13.1% for Integrilin versus 7.6% for placebo).
Danish: Under behandling med Integrilin i denne undersøgelse var mindre blødning en meget almindelig komplikation (> 1/10 eller 13,1 % for Integrilin mod 7,6 % for placebo).
English: What you need to know before you are given Integrilin
Danish: Det skal du vide, før du begynder at få Integrilin
English: Consequently the use of INTEGRILIN is not recommended in these circumstances (see section 4.5).
Danish: INTEGRILIN bør derfor ikke anvendes i sådanne tilfælde (se pkt.
English: INTEGRILIN is intended for use with acetylsalicylic acid and unfractionated heparin.
Danish: INTEGRILIN er beregnet til anvendelse sammen med acetylsalicylsyre og ufraktioneret heparin.
English: In the same population, plasma elimination half-life is approximately 2.5 hours, plasma clearance 55 to 80 ml/kg/hr and volume of distribution of approximately 185 to 260 ml/kg.
Danish: I samme population er plasmaeliminationshalveringstiden cirka 2,5 timer, plasmaclearance 55 til 80 ml/kg/time og+fordelingsvolumen cirka 185 til 260 ml/kg.
English: In the absence of compatibility studies, INTEGRILIN must not be mixed with other medicinal products except those mentioned in 6.6.
Danish: Da der ikke foreligger studier af eventuelle uforligeligheder, må INTEGRILIN ikke blandes med andre lægemidler end dem, der er anført under pkt.
English: Similar differences were noted for TIMI major haemorrhage (118 [2.5%] in early routine use vs. 83 [1.8%] in delayed provisional use; p=0.016).
Danish: Tilsvarende forskelle blev konstateret for TIMI major blødning (118 [2,5 %] ved tidlig rutinemæssig brug i forhold til 83 [1,8 %] ved forsinket provisorisk brug; p=0,016).
English: Arterial sheaths may be removed when coagulation has returned to normal (e.g. when activated clotting time (ACT) is less than 180 seconds (usually 26 hours after discontinuation of heparin).
Danish: Arteriespidsen kan fjernes, når koagulationen er vendt tilbage til det normale, svarende til at aktiveret koagulationstid (ACT) er mindre end 180 sekunder (almindeligvis 2-6 timer efter seponering af heparin).
English: INTEGRILIN did not appear to increase the risk of major and minor bleeding associated with concomitant use of warfarin and dipyridamole.
Danish: INTEGRILIN synes ikke at give en øget risiko for større eller mindre blødninger i forbindelse med samtidig brug af warfarin og dipyridamol.
English: The pivotal clinical trial for Unstable Angina (UA)/Non-Q Wave Myocardial Infarction (NQMI) was PURSUIT.
Danish: Den grundlæggende kliniske undersøgelse ved ustabil angina (UA)/non-Q-tak-myokardieinfarkt (NQMI) var PURSUIT.
English: The incidence of severe or life threatening bleeding events with Integrilin was 1.9% compared to 1.1% with placebo.
Danish: Forekomsten af svære eller livstruende blødningshændelser med Integrilin var 1,9 % sammenlignet med 1,1 % med placebo.
English: Data are limited on the use of INTEGRILIN in patients receiving thrombolytic agents.
Danish: Data er begrænsede for anvendelse af INTEGRILIN til patienter, der får trombolytiske stoffer.
English: Glaxo Operations UK Ltd., (Trading as Glaxo Wellcome Operations), Harmire Road, Barnard Castle, Co. Durham, DL12 8DT, United Kingdom
Danish: Glaxo Operations UK Ltd. (Trading as Glaxo Wellcome Operations), Harmire Road, Barnard Castle, Co. Durham, DL12 8DT, Storbritannien
English: PURSUIT: This was a randomised, double-blind evaluation of the efficacy and safety of Integrilin versus placebo for reducing mortality and myocardial (re)infarction in patients with unstable angina or non-Q-wave myocardial infarction.
Danish: PURSUIT: Dette var en randomiseret, dobbeltblindet vurdering af virkning og sikkerhed af Integrilin versus placebo til at reducere mortalitet og myokardie(re)infarkt hos patienter med ustabil angina eller non-Q-tak-myokardieinfarkt.
English: Integrilin is given into the vein by direct injection followed by an infusion (drip solution).
Danish: Integrilin gives i en blodåre ved direkte injektion efterfulgt af infusion (drop).
English: INTEGRILIN is compatible with 0.9 % sodium chloride solution for infusion and with dextrose 5 % in Normosol R with or without potassium chloride.
Danish: INTEGRILIN er forligeligt med 0,9 % natriumchlorid injektionsvæske og med glucose 5 % i Normosol R med eller uden kaliumchlorid.
English: INTEGRILIN infusion should be stopped immediately if circumstances arise that necessitate thrombolytic therapy or if the patient must undergo an emergency CABG surgery or requires an intraortic balloon pump.
Danish: Infusion med INTEGRILIN skal afbrydes øjeblikkeligt, hvis der opstår situationer, der kræver trombolytisk behandling, eller hvis patienten skal gennemgå en akut CABG-operation eller har behov for en ballonpumpe i aorta.
English: Early routine eptifibatide in this high-risk NSTE-ACS optimally-treated population who were managed with an invasive strategy did not result in a statistically significant reduction in the composite primary endpoint of rate of death, MI, RI-UR, and TBO within 96 hours compared with a regimen of delayed provisional eptifibatide (9.3% in early eptifibatide patients vs. 10.0% in patients assigned to delayed provisional eptifibatide; odds ratio=0.920; 95% CI=0.802-1.055; p=0.234).
Danish: Tidlig rutinemæssig eptifibatid hos denne optimalt behandlede population med akut koronarsyndrom uden ST-elevation i højrisikogruppe, som blev behandlet med invasiv strategi, resulterede ikke i en statistisk signifikant reduktion i det sammensatte primære endepunkt (dødsrate, MI, RI-UR og TBO inden for 96 timer) sammenlignet med et regimen med forsinket provisorisk eptifibatid (9,3 % hos patienter med tidlig eptifibatid i forhold til 10,0 % hos patienter, der blev allokeret til forsinket provisorisk eptifibatid; odds ratio = 0,920; 95 % CI = 0,802-1,055; p = 0,234).
English: LIST OF EXCIPIENTS Citric acid monohydrate, sodium hydroxide, water for injections.
Danish: LISTE OVER HJÆLPESTOFFER Citronsyremonohydrat, natriumhydroxid, vand til injektionsvæsker.
English: The need for blood transfusions was increased modestly by Integrilin treatment (11.8% versus 9.3% for placebo).
Danish: Behandling med Integrilin øgede i moderat grad behovet for blodtransfusioner (11,8 % mod 9,3 % for placebo).
English: GUSTO moderate or severe/life threatening bleeding occurred significantly more often with early routine eptifibatide (7.4% vs. 5.0% in delayed provisional eptifibatide group; p <0.001).
Danish: GUSTO moderat eller svær/livstruende blødning forekom signifikant hyppigere ved tidlig rutinemæssig eptifibatid (7,4 % i forhold til 5,0 % i gruppen med forsinket provisorisk eptifibatid; p < 0,001).
English: If either a confirmed platelet decrease to < 100,000/mm3 or acute profound thrombocytopaenia is observed, discontinuation of each treatment medication having known or suspected thrombocytopenic effects, including eptifibatide, heparin and clopidogrel, should be considered immediately.
Danish: Hvis enten trombocyttallet falder til < 100.000/mm3, eller der observeres akut, markant trombocytopeni, skal det straks overvejes at afbryde behandlingen med lægemidler, der vides eller formodes at kunne medføre trombocytopeni, herunder eptifibatid, heparin og clopidogrel.
English: These plasma concentrations are achieved rapidly when the infusion is preceded by a 180 microgram/kg bolus.
Danish: De nævnte plasmakoncentrationer opnås hurtigt, når infusionen forudgås af en 180 mikrogram/kg bolusinjektion.
English: INTEGRILIN is indicated for the prevention of early myocardial infarction in adults presenting with unstable angina or non-Q-wave myocardial infarction, with the last episode of chest pain occurring within 24 hours and with electrocardiogram (ECG) changes and/or elevated cardiac enzymes.
Danish: INTEGRILIN er indiceret til forebyggelse af tidligt opstående myokardieinfarkt hos voksne med ustabil angina eller non-Q-tak-myokardieinfarkt med det sidste anfald af brystsmerter inden for 24 timer og med elektrokardiogram (ekg)-ændringer og/eller forhøjede hjerteenzymer.
English: INTEGRILIN and thrombolytic agents
Danish: INTEGRILIN og trombolytiske stoffer
English: If percutaneous coronary intervention (PCI) is performed during Integrilin therapy, the intravenous solution may be continued for up to 96 hours.
Danish: Hvis perkutan koronarintervention (PCI) foretages under behandlingen med Integrilin, kan behandlingen fortsættes i indtil 96 timer.
English: Major bleeding was also very common and reported more frequently with Integrilin than with placebo in the PURSUIT study (>1/10 or 10.8% versus 9.3%), but it was infrequent in the vast majority of patients who did not undergo CABG within 30 days of inclusion in the study.
Danish: Større blødninger var også en meget almindelig komplikation og blev rapporteret hyppigere hos de patienter der blev behandlet med Integrilin end hos dem, der fik placebo i PURSUIT-undersøgelsen (> 1/10 eller 10,8 % mod 9,3 %), men det var ikke almindeligt hos størstedelen af de patienter, der ikke gennemgik CABG inden for 30 dage efter inklusion i studiet.
English: There is limited therapeutic experience with INTEGRILIN in patients for whom thrombolytic therapy is generally indicated (e.g. acute transmural myocardial infarction with new pathological Q-waves or elevated ST-segments or left bundle branch block in the ECG).
Danish: Der er begrænsede terapeutiske erfaringer med INTEGRILIN til patienter med generel indikation for trombolytisk behandling (f.eks. akut transmural myokardieinfarkt med nye patologiske Q-takker eller forhøjet ST-segmenter eller venstresidigt ledningsblok i ekg).
English: GlaxoSmithKline Manufacturing S.P.A., Strada Provinciale Asolana No. 90, San Polo di Torrile 43056, Parma, Italy
Danish: GlaxoSmithKline Manufacturing S.P.A., Strada Provinciale Asolana No. 90, San Polo di Torrile 43056, Parma, Italien
English: Other medicines and Integrilin
Danish: Brug af anden medicin sammen med Integrilin
English: Patients most likely to benefit from INTEGRILIN treatment are those at high risk of developing myocardial infarction within the first 3-4 days after onset of acute angina symptoms including for instance those that are likely to undergo an early PTCA (Percutaneous Transluminal Coronary Angioplasty) (see section 5.1).
Danish: De patienter, som mest sandsynligt vil have gavn af INTEGRILIN behandling, er de, som har høj risiko for at udvikle myokardieinfarkt inden for de første 3-4 dage, efter at de akutte anginasymptomer debuterede inklusive fx de patienter, som med stor sandsynlighed skal have foretaget en tidlig PTCA (perkutan transluminal koronar angioplastik) (se pkt.