FrancophonIA/ELRC3.0 huggingface dataset:
English: CARTONS - PACK SIZES 30 AND 100 TABLETS
Croatian: KUTIJE - VELIČINE PAKIRANJA OD 30 I 100 TABLETA
English: 60 mL oral solution.
Croatian: 60 ml oralne otopine.
English: Store in the original bottle in order to protect from light.
Croatian: Čuvati u originalnoj boci radi zaštite od svjetlosti.
English: Do not attempt to remove the syringe adapter from the bottle once inserted.
Croatian: Nemojte pokušati izvaditi nastavak za štrcaljku nakon što ste ga stavili u bocu.
English: A loading dose should be considered in addition to a new maintenance dose when it is necessary to considerably increase sirolimus trough concentrations: Rapamune loading dose=3 x (new maintenance dose - current maintenance dose).
Croatian: U obzir dolazi udarna doza uz novu dozu održavanja ako je potrebno značajno povećati najnižu koncentraciju sirolimusa: udarna doza Rapamunea = 3 x (nova doza održavanja - trenutna doza održavanja).
English: Based on the poor aqueous solubility and high erythrocyte and plasma protein binding of Rapamune, it is anticipated that Rapamune will not be dialysable to any significant extent.
Croatian: Zbog slabe topljivosti u vodi i visokog stupnja vezanja Rapamunea na eritrocite i proteine plazme može se pretpostaviti da nije moguće u značajnijoj mjeri ukloniti Rapamune dijalizom.
English: If bubbles form in the oral solution in the dosing syringe during withdrawal, empty the Rapamune solution back into the bottle and repeat the withdrawal procedure.
Croatian: Ako se u dozirnoj štrcaljki tijekom izvlačenja oralne otopine stvore mjehurići, ispraznite štrcaljku od otopine Rapamune tako što ćete istisnuti otopinu natrag u bocu i ponovite postupak izvlačenja otopine.
English: Immunosuppressive agents (Renal transplant patients only)
Croatian: Imunosupresivi (samo za bolesnike s transplantiranim bubregom)
English: These effects have been reversible upon discontinuation of Rapamune in most cases (see section 5.3).
Croatian: U većini slučajeva učinci su bili reverzibilni nakon prestanka uzimanja Rapamunea (vidjeti dio 5.3).
English: Sirolimus did not affect the pharmacokinetics of either diltiazem or its metabolites desacetyldiltiazem and desmethyldiltiazem.
Croatian: Sirolimus nije utjecao ni na farmakokinetiku diltiazema, niti njegovih metabolita dezacetildiltiazema i dezmetildiltiazema.
English: Maintenance therapy
Croatian: Terapija održavanja
English: On average, the sirolimus dose will need to be 4-fold higher to account for both the absence of the pharmacokinetic interaction (2-fold increase) and the augmented immunosuppressive requirement in the absence of ciclosporin (2-fold increase).
Croatian: U prosjeku bi doza sirolimusa trebala biti 4 puta viša kako bi se uračunala odsutnost farmakokinetičke interakcije (dvostruko povećanje) i povećana potreba za imunosupresivom u odsutnosti ciklosporina (dvostruko povećanje).
English: The tablets are supplied in blister packs of 30 and 100 tablets.
Croatian: Tablete su dostupne u blister pakiranjima s 30 ili 100 tableta.
English: After a single dose of [14C] sirolimus in healthy volunteers, the majority (91.1%) of radioactivity was recovered from the faeces, and only a minor amount (2.2%) was excreted in urine.
Croatian: C] sirolimusa u zdravih dobrovoljaca, veći dio (91,1%) radioaktivnosti pronađen je u fecesu, a tek je u manjoj količini (2,2%) izlučen u urinu.
English: The difference in bioavailability was less marked upon steady-state administration to renal transplant recipients, and therapeutic equivalence has been demonstrated in a randomised study of 477 patients.
Croatian: Razlika u bioraspoloživosti bila je manje izražena prilikom davanja s postizanjem stanja dinamičke ravnoteže u primatelja renalnog presatka, dok je terapijska ekvivalencija dokazana u slučajno odabranom ispitivanju u 477 bolesnika.
English: Sirolimus administered concomitantly (5 mg), and at 2 hours (5 mg) and 4 hours (10 mg) after CsA (300 mg), resulted in increased sirolimus AUC by approximately 183%, 141% and 80%, respectively.
Croatian: Primjena sirolimusa istodobno (5 mg) te 2 sata (5 mg) odnosno 4 sata (10 mg) nakon ciklosporina A (300 mg) dovela je do porasta AUC sirolimusa za otprilike 183%, 141% odnosno 80%.
English: Currently in clinical practice, sirolimus whole blood concentrations are being measured by both chromatographic and immunoassay methodologies.
Croatian: Trenutno se u kliničkoj praksi koncentracija sirolimusa u punoj krvi određuje kako kromatografskom, tako i metodom imunotesta.
English: Your doctor will need to perform blood tests to measure Rapamune concentrations.
Croatian: Liječnik će Vam morati vaditi krv kako bi izmjerio koncentracije Rapamunea.
English: The mean calculated glomerular filtration rate (GFR) at 12, 24, 36, 48 and 60 months was significantly higher for patients receiving Rapamune following ciclosporin elimination than for those in the Rapamune with ciclosporin therapy group.
Croatian: Srednja vrijednost izračunate brzine glomerularne filtracije (GFR) nakon 12, 24, 36, 48 i 60 mjeseci bila je značajno veća u bolesnika koji su primali Rapamune nakon isključenja ciklosporina nego u skupini onih koji su primali Rapamune i ciklosporin.
English: Effective contraception must be used during Rapamune therapy and for 12 weeks after Rapamune has been stopped (see section 4.5).
Croatian: Tijekom terapije Rapamuneom mora se koristiti učinkovita kontracepcija, kao i 12 tjedana nakon prestanka uzimanja Rapamunea (vidjeti dio 4.5).
English: Frequent Rapamune dose adjustments based on non-steady-state sirolimus concentrations can lead to overdosing or underdosing because sirolimus has a long half-life.
Croatian: Česte prilagodbe doza lijeka Rapamune na temelju koncentracija sirolimusa mjerenih izvan stanja dinamičke ravnoteže mogu dovesti do predoziranja ili poddoziranja jer sirolimus ima dug poluvijek.
English: How to take Rapamune
Croatian: Kako uzimati Rapamune
English: Elevated sirolimus levels, for example due to interaction with strong CYP3A4 inhibitors, (with/without concomitant ACE inhibitors) may also potentiate angioedema (see section 4.5).
Croatian: Povišene razine sirolimusa, primjerice zbog interakcije sa snažnim inhibitorima CYP3A4, (sa ili bez istodobnih ACE inhibitora) također mogu potencirati angioedem (vidjeti dio 4.5).
English: Therefore, the sirolimus dose was approximately 4-fold higher to account for both the absence of the pharmacokinetic interaction with ciclosporin (2-fold increase) and the augmented immunosuppressive requirement in the absence of ciclosporin (2-fold increase).
Croatian: Stoga je doza sirolimusa bila otprilike 4 puta veća kako bi se uračunala kako odsutnost farmakokinetičke interakcije s ciklosporinom (povećanje od 2 puta), tako i povećana potreba za imunosupresijom u odsutnosti ciklosporina (povećanje od 2 puta).
English: In two clinical studies in de novo liver transplant patients, the use of sirolimus plus ciclosporin or tacrolimus was associated with an increase in hepatic artery thrombosis, mostly leading to graft loss or death.
Croatian: U dva klinička ispitivanja u bolesnika s de novo presađenom jetrom, primjena sirolimusa zajedno s ciklosporinom ili takrolimusom bila je povezana s porastom tromboze hepatičke arterije, što je najčešće dovodilo do gubitka presatka ili smrti.
English: In some cases, ovarian cysts and these menstrual disorders have resolved upon discontinuation of Rapamune.
Croatian: U nekim slučajevima, ovarijske ciste i navedeni poremećaji menstrualnog ciklusa povukli su se nakon prekida primjene Rapamunea.
English: Sirolimus is a substrate for both cytochrome P450 IIIA4 (CYP3A4) and P-glycoprotein.
Croatian: Sirolimus je supstrat kako za citokrom P450 IIIA4 (CYP3A4), tako i za P-glikoprotein.
English: Prophylaxis of organ rejection
Croatian: Profilaksa odbacivanja organa
English: Increased susceptibility to infection and the possible development of lymphoma and other malignancies, particularly of the skin, may result from immunosuppression (see section 4.8).
Croatian: Povećana sklonost infekcijama i mogući razvoj limfoma i drugih zloćudnih bolesti, posebice kože, mogu biti posljedica imunosupresije (vidjeti dio 4.8).
English: Also contains: ethanol, propylene glycol (E1520), soya fatty acids.
Croatian: Također sadrži: etanol, propilenglikol (E1520), masne kiseline soje.
English: It is recommended that a trough concentration be taken 1 or 2 weeks after switching formulations or tablet strength to confirm that the trough concentration is within the recommended target range.
Croatian: Preporučuje se određivanje najniže koncentracije lijeka u krvi 1 ili 2 tjedna nakon promjene formulacije ili jačine tablete radi potvrde da se najniža koncentracija lijeka nalazi unutar preporučenog ciljnog raspona.
English: Cases of Pneumocystis carinii pneumonia have been reported in renal transplant patients not receiving antimicrobial prophylaxis.
Croatian: Opisani su slučajevi pneumonije uzrokovane Pneumocystis carinii u bolesnika s transplantiranim bubregom koji nisu primali antimikrobnu profilaksu.
English: It is recommended that Rapamune be used first in combination with ciclosporin and corticosteroids.
Croatian: Preporučuje se prvo uzimati Rapamune u kombinaciji s ciklosporinom i kortikosteroidima.
English: In rats, sirolimus caused embryo/foetotoxicity that was manifested as mortality and reduced foetal weights (with associated delays in skeletal ossification) (see section 4.6).
Croatian: U štakora je sirolimus uzrokovao embrio/fetotoksičnost koja se manifestirala mortalitetom i smanjenom fetalnom težinom (s povezanim zastojima okoštavanja kostura) (vidjeti dio 4.6).
English: Refill the container with an additional volume (minimum of 120 mL) of water or orange juice, stir vigorously, and drink at once.
Croatian: Ponovno napunite spremnik dodatnim volumenom (najmanje 120 ml) vode ili soka od naranče, žustro promiješajte i odmah popijte.
English: Reductions in testicular weights and/or histological lesions (e.g. tubular atrophy and tubular giant cells) were observed in rats and in a monkey study.
Croatian: Smanjenje težine testisa i/ili histološke lezije (npr. tubularna atrofija i tubularne gigantske stanice) opaženi su u ispitivanjima na štakorima i majmunima.
English: Similarly the risk/benefit of continued Rapamune therapy should be re-evaluated in patients with severe refractory hyperlipidaemia.
Croatian: Slično tome, potrebno je ponovno razmotriti omjer rizika i koristi od nastavka terapije Rapamuneom u bolesnika s teškom refraktornom hiperlipidemijom.
English: The net result is the inhibition of lymphocyte activation, which results in immunosuppression.
Croatian: Konačni učinak je inhibicija aktivacije limfocita, što dovodi do imunosupresije.
English: Patients taking Rapamune should discontinue breast-feeding.
Croatian: Bolesnice koje uzimaju Rapamune moraju prestati dojiti.
English: Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions, angioedema, exfoliative dermatitis, and hypersensitivity vasculitis, have been associated with the administration of sirolimus (see section 4.8).
Croatian: Reakcije preosjetljivosti, uključujući anafilaktične/anafilaktoidne reakcije, angioedem, eksfolijativni dermatitis i hipersenzitivni vaskulitis povezane su s primjenom sirolimusa (vidjeti dio 4.8).
English: The corresponding results for the oral solution in the same clinical study were Cmin,ss 5.40  2.50 ng/mL, Cmax,ss 14.4  5.3 ng/mL, tmax,ss 2.12  0.84 hours, AUC,ss 194  78 ng.h/mL, CL/F/W 173  50 mL/h/kg.
Croatian: Odgovarajući rezultati za oralnu otopinu u istom kliničkom ispitivanju bili su Cmin,ss 5,40  2,50 ng/ml, Cmax,ss 14,4  5,3 ng/ml, tmax,ss 2,12  0,84 h, AUC,ss 194  78 ng•h/ml, CL/F/W 173  50 ml/h/kg.
English: The continued co-administration of ciclosporin and Rapamune as maintenance therapy cannot be recommended.
Croatian: Ne preporučuje se nastaviti istodobnu primjenu ciklosporina i Rapamunea kao terapije održavanja.
English: S-LAM patients experienced similar side effects to those of kidney transplant patients, with the addition of weight loss, which may affect up to 1 in 10 people.
Croatian: Bolesnici koji boluju od S-LAM-a imali su slične nuspojave kao i bolesnici s presađenim bubregom, uz dodatak gubitka težine, a to se može pojaviti u manje od 1 na 10 osoba.
English: The rates of acute rejection, graft loss, and death were similar, but urinary protein excretion was increased in the Rapamune treatment arm of this subset.
Croatian: Stopa akutnog odbacivanja, gubitka presatka i smrti bila je slična, ali je izlučivanje proteina u urinu bilo povećano u bolesnika u ovoj podskupini koji su liječeni Rapamuneom.
English: Undesirable effects observed with patients with S-LAM
Croatian: Nuspojave opažene u bolesnika koji boluju od S-LAM-a
English: Rapamune tablets administered to 12 renal transplant patients above 65 years of age gave similar results to adult patients (n=167) 18 to 65 years of age.
Croatian: Rapamune tablete primijenjene u 12 bolesnika s presatkom bubrega starijih od 65 godina života dale su rezultate slične onima u odrasloj populaciji (n = 167) u dobi od 18 do 65 godina života.
English: Immunosuppression increases the susceptibility to the development of lymphoma and other malignancies, particularly of the skin (see section 4.4).
Croatian: Imunosupresija povećava sklonost razvoju limfoma i drugih zloćudnih bolesti, osobito kože (vidjeti dio 4.4).
English: Inducers of CYP3A4 (such as rifampin or rifabutin) increase the metabolism of sirolimus and decrease sirolimus levels.
Croatian: Induktori CYP3A4 (kao što su rifampicin ili rifabutin) pojačavaju metabolizam sirolimusa i smanjuju razinu sirolimusa.
English: When refrigerated the solution in the bottle may develop a slight haze.
Croatian: Kad se čuva u hladnjaku, otopina u boci može postati blago zamućena.
English: Multiples of 0.5 mg tablets should not be used as a substitute for the 1 mg tablet or for other strengths (see section 5.2).
Croatian: Ne smiju se uzimati višestruke doza tableta od 0,5 mg kako bi se nadomjestila doza od 1 mg ili druge doze (vidjeti dio 5.2).
English: The incidence of biopsy confirmed acute rejection was higher (p=0.020*) for patients in the sirolimus group (11, 8.4%) compared to the tacrolimus group (2, 1.6%) through 2 years; most rejections were mild in severity (8 of 9 [89%] T-cell BCAR, 2 of 4 [50%] antibody mediated BCAR) in the sirolimus group.
Croatian: Incidencija biopsije potvrdila je da je akutno odbacivanje bilo više (p = 0,020*) u bolesnika u skupini koja je primala sirolimus (11, 8,4%) u usporedbi sa skupinom liječenom takrolimusom (2, 1,6%) kroz dvije godine; većina odbacivanja bila je blagog intenziteta (8 od 9 [89%] BCAR posredovan T-stanicama, 2 od 4 [50%] protutijelima posredovan BCAR) u skupini sa sirolimusom.
English: There were more adverse events (99.2% vs. 91.1%, p=0.002*) and more discontinuations from the treatment due to adverse events (26.7% vs. 4.1%, p<0.001*) in the group converted to sirolimus compared to the tacrolimus group.
Croatian: Bilo je više štetnih događaja (99,2% naspram 91,1%, p=0,002*) i prestanak liječenja zbog štetnih događaja (26,7% naspram 4,1%, p<0.001*) u skupini koja je prebačena na sirolimus u usporedbi sa skupinom koja je liječena takrolimusom.
English: At steady-state, 8 children aged 6-11 years received mean  SD doses of 1.75  0.71 mg/day (0.064  0.018 mg/kg, 1.65  0.43 mg/m2) while 14 adolescents aged 12-18 years received mean  SD doses of 2.79  1.25 mg/day (0.053  0.0150 mg/kg, 1.86  0.61 mg/m2).
Croatian: U stanju dinamičke ravnoteže 8 djece u dobi 6-11 godina primilo je srednju vrijednost  SD doze od 1,75  0,71 mg/dan (0,064  0,018 mg/kg, 1,65  0,43 mg/m2), dok je 14 adolescenata u dobi 12-18 godina primilo srednju vrijednost  SD doze od 2,79  1,25 mg/dan (0,053  0,0150 mg/kg, 1,86  0,61 mg/m2).
English: Empty the correct amount of Rapamune from the syringe into only a glass or plastic container with at least 60 mL of water or orange juice.
Croatian: Ispraznite ispravnu količinu Rapamunea iz štrcaljke u spremnik koji smije biti samo od stakla ili plastike i sadrži najmanje 60 ml vode ili soka od naranče.
English: Experimental evidence suggests that sirolimus binds to the specific cytosolic protein FKPB-12, and that the FKPB 12-sirolimus complex inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a critical kinase for cell cycle progression.
Croatian: Eksperimentalni dokazi upućuju na to da se sirolimus veže na specifični protein FKPB-12u citosolu, te da kompleks FKPB 12-sirolimus inhibira aktivaciju ciljnog mjesta rapamicina u sisavaca (engl. mammalian Target Of Rapamycin, mTOR), najvažnije kinaze za progresiju staničnog ciklusa.
English: For skin carcinoma, the median time to first occurrence was significantly delayed.
Croatian: Medijan vremena do prve pojave karcinoma kože bilo je značajno odgođeno za tu skupinu.
English: The terminal half-life in stable renal transplant patients after multiple oral doses was 6216h.
Croatian: Poluvijek eliminacije u bolesnika sa stabilnim presatkom bubrega nakon višekratnih oralnih doza iznosio je 62  16h.
English: Sucrose and lactose
Croatian: Saharoza i laktoza
English: An initial dose of 6 mg contains up to 150 mg of alcohol which is equivalent to 3.80 mL beer or 1.58 mL wine.
Croatian: Početna doza od 6 mg sadrži do 150 mg alkohola, što odgovara 3,80 ml piva ili 1,58 ml vina.
English: Rapamune may be continued as maintenance therapy with corticosteroids only if ciclosporin microemulsion can be progressively discontinued (see sections 4.2 and 5.1).
Croatian: Liječenje Rapamuneom može se nastaviti kao terapija održavanja s kortikosteroidima samo ako je moguće postupno ukinuti mikroemulziju ciklosporina (vidjeti dijelove 4.2 i 5.1).
English: Sirolimus concentrations were measured in concentration-controlled studies of paediatric renal-transplant patients who were also receiving ciclosporin and corticosteroids.
Croatian: Koncentracije sirolimusa određivane su u ispitivanjima s kontrolom koncentracije u pedijatrijskih bolesnika s presađenim bubregom, koji su također primali ciklosporin i kortikosteroide.
English: At 48 months, there was a statistically significant difference in graft survival in favour of the Rapamune following ciclosporin elimination group compared to the Rapamune with ciclosporin therapy group (including and excluding loss to follow-up).
Croatian: Nakon 48 mjeseci, opažena je statistički značajna razlika u preživljenju presatka u korist skupine liječene Rapamuneom nakon uklanjanja ciklosporina, u usporedbi sa skupinom liječenom Rapamuneom i ciklosporinom (uključujući i isključujući bolesnike izgubljene iz praćenja).
English: If you have a body mass index (BMI) greater than 30 kg/m2, you may be at increased risk of abnormal wound healing.
Croatian: Ako imate indeks tjelesne mase (BMI) veći od 30 kg/m 2, možete imati povećan rizik od otežanog cijeljenja rana.
English: Before vaccinations, please inform your doctor or pharmacist that you are receiving Rapamune.
Croatian: Prije cijepljenja obavijestite svog liječnika ili ljekarnika da uzimate Rapamune.
English: Patients at high immunological risk of graft loss were not studied in sufficient number in the ciclosporin elimination-Rapamune maintenance studies and are not recommended for this treatment regimen.
Croatian: Bolesnici s visokim imunološkim rizikom od gubitka presatka nisu ispitani u dovoljnom broju u ispitivanjima s prekidom davanja ciklosporina uz nastavak liječenja Rapamuneom te se stoga za njih ne preporučuje ovaj protokol liječenja.
English: Adjustments to the targeted range should be made according to the assay being utilised to determine the sirolimus trough concentrations.
Croatian: Prilagodbu ciljanom rasponu treba vršiti sukladno korištenoj metodi određivanja najniže koncentracije sirolimusa.
English: Ciclosporin was not withdrawn in patients experiencing Banff Grade 3 acute rejection episodes, who were dialysis-dependent, who had a serum creatinine higher than 400 mol/L, or who had inadequate renal function to support ciclosporin withdrawal.
Croatian: Ciklosporin nije ukinut u bolesnika koji su doživjeli epizode akutnog odbacivanja 3. stupnja po Banffu, koji su bili ovisni o dijalizi, koji su imali kreatinin u serumu viši od 400 mol/l i onih koji nisu imali zadovoljavajuću funkciju bubrega koja bi dopuštala ukidanje ciklosporina.
English: Based on information from an open-label randomised study, conversion from the calcineurin inhibitor tacrolimus to Rapamune in maintenance renal transplant patients was associated with an unfavourable safety profile without efficacy benefit and can therefore not be recommended (see section 5.1).
Croatian: Na temelju podataka iz otvorenog randomiziranog ispitivanja, prelazak s kalcineurinskog inhibitora takrolimusa na Rapamune u bolesnika koji održavaju presadak bubrega bio je povezan s nepovoljnim sigurnosnim profilom, bez postizanja koristi u smislu djelotvornosti, te se stoga ne može preporučiti za primjenu (vidjeti dio 5.1).
English: Sirolimus is also a substrate for the multidrug efflux pump, P-glycoprotein (P-gp) located in the small intestine.
Croatian: Sirolimus je također supstrat za efluksnu crpku za više lijekova, P-glikoprotein (P-gp) koji se nalazi u tankom crijevu.
English: The key inclusion criteria was post-bronchodilator forced expiratory volume in 1 second (FEV1) ≤70% of predicted during the baseline visit.
Croatian: Ključni kriterij uključivanja u ispitivanje bio je forsirani ekspiratorni volumen u 1. sekundi (FEV1) ≤ 70% od predviđene vrijednosti nakon primjene bronhodilatatora na početnom posjetu.
English: Sirolimus is extensively metabolised by the CYP3A4 isozyme in the intestinal wall and liver.
Croatian: Sirolimus se opsežno metabolizira putem izoenzima CYP3A4 u stijenci crijeva i jetri.
English: Following administration of the Rapamune oral solution, sirolimus is rapidly absorbed, with a time to peak concentration of 1 hour in healthy subjects receiving single doses and 2 hours in patients with stable renal allografts receiving multiple doses.
Croatian: Nakon primjene Rapamune oralne otopine, sirolimus se brzo apsorbira i postiže vršnu koncentraciju za 1 sat u zdravih osoba koje su primile jednokratnu dozu, odnosno 2 sata u bolesnika sa stabilnim alopresadcima bubrega koji su primili višekratne doze.
English: Your doctor will perform tests to monitor the levels of Rapamune in your blood.
Croatian: Liječnik će raditi pretrage kojima će pratiti razine lijeka Rapamune u Vašoj krvi.
English: Your dose will be adjusted depending on the level of Rapamune in your blood.
Croatian: Dozu će Vam prilagoditi ovisno o razini lijeka Rapamune u krvi.
English: In a randomised, comparative evaluation of ramipril versus placebo for the prevention of proteinuria in kidney transplant patients converted from calcineurin inhibitors to sirolimus, a difference in the number of patients with BCAR through 52 weeks was observed [13 (9.5%) vs. 5 (3.2%), respectively; p=0.073].
Croatian: U randomiziranom, usporednom procjenjivanju ramiprila u odnosu na placebo za prevenciju proteinurije u bolesnika s presađenim bubregom koji su prešli s inhibitora kalcineurina na sirolimus, primijećena je razlika u broju bolesnika s BCAR tijekom 52 tjedna [13 (9,5%) u usporedbi s 5 (3,2%); p = 0,073].
English: Rapamune therapy should be optimised with a tapering regimen of steroids and ciclosporin microemulsion.
Croatian: Terapija Rapamuneom mora se optimizirati postupnim smanjivanjem doze steroida i mikroemulzije ciklosporina.
English: In animals, sirolimus has a direct effect on T- and B-cell activation, suppressing immune-mediated reactions, such as allograft rejection.
Croatian: U životinja sirolimus ima izravan učinak na aktivaciju B i T limfocita, te tako suprimira imunološki posredovane reakcije kao što je odbacivanje alopresatka.
English: It helps to control your body's immune system after you have received a kidney transplant.
Croatian: Sirolimus pomaže u kontroli Vašeg imunološkog sustava nakon presađivanja bubrega.