FrancophonIA/ELRC3.0 huggingface dataset:
English: Talk to your doctor or pharmacist before using Stelara.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primijenite Stelaru.
English: Approximately one third (Psoriasis Study 1) and one quarter (Psoriasis Study 2) of subjects had Psoriatic Arthritis (PsA).
Croatian: Približno jedna trećina (Ispitivanja psorijaze 1) i jedna četvrtina (Ispitivanja psorijaze 2) ispitanika imala je psorijatični artritis (PsA).
English: The most frequently observed malignancies, other than non-melanoma skin cancer, were prostate, colorectal, melanoma and breast cancers.
Croatian: Najčešće zabilježene maligne bolesti, osim nemelanomskog karcinoma kože, bile su karcinom prostate, kolorektalni karcinom, melanom i rak dojke.
English: Uncommon: Depression
Croatian: Manje često: depresija
English: Do not use this medicine:
Croatian: Ovaj lijek se ne smije primijeniti:
English: Never re-use needles and syringes, for your safety and health, and for the safety of others.
Croatian: Nikada ne upotrebljavajte već upotrijebljene igle i štrcaljke zbog vlastite sigurnosti i zdravlja te zbog sigurnosti drugih.
English: Anaphylaxis and angioedema have occurred.
Croatian: Zabilježena je pojava anafilaksije i angioedema.
English: Patients in these studies had a diagnosis of PsA for at least 6 months.
Croatian: U ovim ispitivanjima, PsA je bolesnicima dijagnosticiran prije najmanje 6 mjeseci.
English: Fertility The effect of ustekinumab on human fertility has not been evaluated (see section 5.3).
Croatian: Plodnost Djelovanje ustekinumaba na plodnost u ljudi nije procijenjeno (vidjeti dio 5.3).
English: Patients who have not shown adequate response at 8 weeks after the first subcutaneous dose, may receive a second subcutaneous dose at this time (see section 5.1).
Croatian: Bolesnici koji nisu pokazali adekvatan odgovor u 8 tjedana nakon prve supkutane doze, mogu u to vrijeme primiti drugu supkutanu dozu (vidjeti dio 5.1).
English: If you do not respond well enough or are intolerant to these medicines, you may be given Stelara to reduce the signs and symptoms of your disease.
Croatian: Ako ne odgovorite dovoljno dobro na njih ili ako ne podnosite te lijekove, može Vam se primijeniti Stelara za ublažavanje znakova i simptoma
English: Structural damage in both hands and feet was expressed as change in total van der Heijde-Sharp score (vdH-S score), modified for PsA by addition of hand distal interphalangeal joints, compared to baseline.
Croatian: Strukturna oštećenja u obje šake i u stopalima bila su izražena kao promjena ukupnog van der HeijdeSharp-ovog boda (vdH-S score), modificirano za PsA uz dodavanje distalnih interfalangealnih zglobova šake, u odnosu na početne vrijednosti.
English: STELARA should be discontinued if a drug reaction is suspected.
Croatian: Liječenje STELAROM se mora prekinuti ako se sumnja na reakciju na lijek.
English: Approximately 6 mg/kg
Croatian: Približno 6 mg/kg
English: Remove the needle cover (see Figure 3):
Croatian: Uklonite zaštitnu kapicu igle (pogledajte sliku 3):
English: • Plaque psoriasis - in adults and children aged 6 years and older
Croatian: • Plak psorijaza - u odraslih i djece u dobi od 6 godina i starijih
English: Psoriasis Study 1 (PHOENIX 1) evaluated 766 patients.
Croatian: Ispitivanje psorijaze 1 (PHOENIX 1) procijenilo je 766 bolesnika.
English: The results of an in vitro study do not suggest the need for dose adjustments in patients who are receiving concomitant CYP450 substrates (see section 5.2).
Croatian: Rezultati in vitro ispitivanja ne pokazuju potrebu za prilagodbama doze u bolesnika koji istodobno primaju supstrate enzima CYP450 (vidjeti dio 5.2).
English: • Moderate to severe Crohn's disease - in adults
Croatian: • Umjerena do teška Crohnova bolest - u odraslih
English: All patients, in particular those greater than 60 years of age, patients with a medical history of prolonged immunosuppressant therapy or those with a history of PUVA treatment, should be monitored for the appearance of non-melanoma skin cancer (see section 4.8).
Croatian: Svi bolesnici, naročito oni stariji od 60 godina, bolesnici s produljenom imunosupresivnom terapijom u povijesti bolesti ili oni koji su bili liječeni PUVA-om, moraju se nadzirati radi pojave nemelanomskog raka kože (vidjeti dio 4.8).
English: PedsQL: The PedsQL Total Scale Score is a general health-related quality of life measure developed for use in children and adolescent populations.
Croatian: PedsQL: PedsQL Zbroj ukupne skale je općenita mjera kvalitete života povezana sa zdravljem, razvijena za primjenu u djece i adolescenata.
English: Concomitant use of immunomodulators did not have a significant impact on ustekinumab disposition.
Croatian: Istodobna primjena imunomodulatora nije značajno utjecala na raspoloživost ustekinumaba.
English: • A change in psoriasis with redness and new tiny, yellow or white skin blisters, sometimes accompanied by fever (pustular psoriasis)
Croatian: • promjene u psorijazi uz crvenilo i nove sitne žute ili bijele mjehuriće na koži, ponekad praćene vrućicom (pustularna psorijaza).
English: Justification for not including in Braille accepted.
Croatian: Prihvaćeno obrazloženje za nenavođenje Brailleovog pisma.
English: Common: Pruritus
Croatian: Često: pruritus
English: • Drooping eyelid and sagging muscles on one side of the face (‘facial palsy' or ‘Bell's palsy'), which is usually temporary
Croatian: • spušteni kapak i opuštenost mišića na jednoj strani lica (‘paraliza lica' ili ‘Bellova paraliza'), što je obično prolazno
English: Choose and prepare the injection site: Choose an injection site (see Figure 2)
Croatian: Odaberite i pripremite mjesta za primjenu injekcije: Odaberite mjesto za primjenu injekcije (pogledajte Sliku 2)
English: If possible, areas of the skin that show psoriasis should be avoided as injection sites.
Croatian: Ako je moguće, područja kože zahvaćena psorijazom trebaju se izbjegavati kao mjesta za davanje injekcije.
English: The infusion solution is to be composed of the number of vials of STELARA 130 mg as specified in Table 1 (see section 6.6 for preparation).
Croatian: Infuzijska otopina treba se sastojati od određenog broja bočica STELARE od 130 mg kako je navedeno u Tablici 1 (vidjeti dio 6.6 za pripremu).
English: ACR 20, 50 and 70 responses continued to improve or were maintained through week 52 (PsA Study 1 and 2) and week 100 (PsA Study 1).
Croatian: Odgovori ACR 20, 50 i 70 su se nastavili poboljšavati ili su zadržani kroz 52 tjedna (PsA Ispitivanje 1 i 2) i 100 tjedana (PsA Ispitivanje 1).
English: Concomitant immunosuppressive therapy
Croatian: Istovremena imunosupresivna terapija
English: • If you have any new or changing lesions within psoriasis areas or on normal skin.
Croatian: • ako imate bilo kakvo novo oštećenje ili promjene oštećenja unutar područja zahvaćenih psorijazom ili na zdravoj koži.
English: In these patients, clinical remission was achieved in 41.4% of patients 16 weeks after dose adjustment.
Croatian: U tih bolesnika, klinička remisija bila je postignuta u 41,4% bolesnika 16 tjedana nakon prilagodbe doze.
English: STELARA treatment is to be initiated with a single intravenous dose based on body weight.
Croatian: Liječenje STELAROM treba se započeti s jednom intravenskom dozom temeljenoj na tjelesnoj težini.
English: STELARA does not contain preservatives; therefore any unused medicinal product remaining in the vial and the syringe should not be used.
Croatian: STELARA ne sadrži konzervanse, stoga se svaka neupotrebljena količina lijeka koja je preostala u bočici ili štrcaljki ne smije primijeniti.
English: • Pick up the pre-filled syringe, hold the body of the syringe with one hand
Croatian: • Uzmite napunjenu štrcaljku, držite tijelo štrcaljke jednom rukom
English: • The needle cover should not be removed until you are ready to inject the dose
Croatian: • Zaštitnu kapicu igle ne smijete uklanjati dok niste spremni za primjenu doze lijeka
English: Patients with body weight > 100 kg
Croatian: Bolesnici tjelesne težine > 100 kg
English: This will let the liquid come to a comfortable temperature for injection (room temperature).
Croatian: To će omogućiti otopini da dosegne ugodnu temperaturu (sobna temperatura) prije injekcije.
English: The incidence of malignancies reported in ustekinumab-treated patients was comparable to the incidence expected in the general population (standardised incidence ratio = 0.93 [95% confidence interval: 0.71, 1.20], adjusted for age, gender and race).
Croatian: Incidencija malignih bolesti prijavljena kod bolesnika liječenih ustekinumabom bila je usporediva s incidencijom koja se očekuje u općoj populaciji (standardizirani omjer incidencije = 0,93 [95% intervala pouzdanosti: 0,71; 1,20], prilagođeno godinama, spolu i rasi).
English: See the package leaflet for further information.
Croatian: Vidjeti uputu o lijeku za više informacija.
English: There are no adequate data from the use of ustekinumab in pregnant women.
Croatian: Nema odgovarajućih podataka vezanih uz primjenu ustekinumaba kod trudnica.
English: STELARA concentrate for solution for infusion should only be used for the intravenous induction dose.
Croatian: STELARA koncentrat za otopinu za infuziju se smije upotrijebljavati samo za intravensku uvodnu dozu.
English: Dose levels in animal studies were up to approximately 45-fold higher than the highest equivalent dose intended to be administered to psoriasis patients and resulted in peak serum concentrations in monkeys that were more than 100-fold higher than observed in humans.
Croatian: Doziranja u ispitivanjima na životinjama bila su približno 45 puta viša od najviše ekvivalentne doze namijenjene za primjenu kod bolesnika s psorijazom i rezultirala su vršnim serumskim koncentracijama kod majmuna koje su bile više od 100 puta više od onih zabilježenih kod ljudi.
English: CDLQI: The CDLQI is a dermatology instrument to assess the effect of a skin problem on the health-related quality of life in the paediatric population.
Croatian: CDLQI: CDLQI je dermatološki alat za ocjenu utjecaja problema s kožom na kvalitetu života povezanu sa zdravljem u pedijatrijskoj populaciji.
English: Patients with PASI ≥ 12, PGA ≥ 3 and BSA involvement of at least 10%, who were candidates for systemic therapy or phototherapy, were eligible for the study.
Croatian: Bolesnici s PASI ≥ 12, PGA ≥ 3 i BSA zahvaćenošću od najmanje 10%, koji su bili kandidati za sustavnu terapiju ili fototerapiju, su bili prikladni za ispitivanje.
English: This should be taken into consideration for patients on a controlled sodium diet (see section 6.6).
Croatian: Ovo treba uzeti u obzir kod bolesnika na dijeti s kontroliranim unosom natrija (vidjeti dio 6.6).
English: • Slowly take your thumb off the plunger head to allow the empty syringe to move up until the entire needle is covered by the needle guard, as shown by Figure 7:
Croatian: • Polako maknite palac s glave klipa štrcaljke i pustite da se prazna štrcaljka povuče prema gore sve dok cijela igla ne bude prekrivena štitnikom igle, kao što je prikazano na slici 7:
English: • Pull on the syringe plunger to fill the syringe with the amount of liquid prescribed by your doctor
Croatian: • Povucite klip štrcaljke kako bi napunili štrcaljku s količinom tekućine iz bočice koju Vam je propisao liječnik.
English: Thus, caution should be exercised when considering the use of STELARA in these patients.
Croatian: Prema tome, mora se biti oprezan kada se razmatra primjena STELARE kod tih bolesnika.
English: If a patient develops a serious infection, the patient should be closely monitored and STELARA should not be administered until the infection resolves.
Croatian: Ako se razvije ozbiljna infekcija bolesnika se mora stalno pratiti, a STELARA se ne smije primjenjivati dok se infekcija ne izliječi.
English: The median time to reach the maximum serum concentration (tmax) was 8.5 days after a single 90 mg subcutaneous administration in healthy subjects.
Croatian: Medijan vremena za dostizanje maksimalne serumske koncentracije (tmax) bilo je 8,5 dana nakon jedne 90 mg supkutane primjene kod zdravih ispitanika.
English: Week 28 3 doses (week 0, week 4 and week 16) PBO 45 mg 90 mg 45 mg 90 mg
Croatian: Tjedan 28 3 doze (Tjedan 0, Tjedan 4 i Tjedan 16) placebo 45 mg 90 mg 45 mg 90 mg
English: If you have ulcerative colitis you will first be given other medicines.
Croatian: Ako imate ulcerozni kolitis, prvo će Vam biti primijenjeni drugi lijekovi.
English: • Gently pinch the cleaned skin between your thumb and index finger.
Croatian: • Nježno uhvatite nabor očišćene kože između palca i kažiprsta.
English: In IM-UNITI, 29 of 129 patients did not maintain response to ustekinumab when treated every 12 weeks and were allowed to dose adjust to receive ustekinumab every 8 weeks.
Croatian: U IM-UNITI, kod 29 od 129 bolesnika nije održan odgovor na ustekinumab kod liječenja svakih 12 tjedana i bila je dozvoljena prilagodba doze kako bi primili ustekinumab svakih 8 tjedana.
English: Once diluted, the infusion should be completed within eight hours of the dilution in the infusion bag.
Croatian: Jednom kada je razrijeđena, infuziju je potrebno završiti unutar osam sati od razrjeđivanja u infuzijskoj vrećici.
English: • Push the plunger with your thumb as far as it will go to inject all of the liquid.
Croatian: • Pritišćite klip štrcaljke palcem koliko ide, sve dok cijela količina tekućine ne bude ubrizgana.
English: Beyond week 12, efficacy was generally higher and better sustained in the recommended dose group compared with half of the recommended dosage group in which a modest loss of efficacy was more frequently observed toward the end of each 12 week dosing interval.
Croatian: Nakon 12. tjedna, djelotvornost je općenito bila više i bolje održana u skupini koja je primala preporučenu dozu u usporedbi sa skupinom koja je primala polovinu preporučene doze u kojoj je češće zabilježen skroman gubitak djelotvornosti prema kraju svakog
English: In Study 2, the majority of patients (58%, n = 180) had been previously treated with one or more anti-TNFα agent(s), of whom over 70% had discontinued their anti-TNFα treatment for lack of efficacy or intolerance at any time.
Croatian: U Ispitivanju 2, većina bolesnika (58%, n = 180) prethodno je liječena s jednim ili više anti-TNFα lijekova, od kojih je preko 70% prekinulo anti-TNFα liječenje zbog neučinkovitosti ili netolerancije u bilo koje doba.
English: In patients who failed conventional therapy, but not a biologic c77% (78/102)
Croatian: U bolesnika neuspješno liječenih konvencionalnom, ali ne i biološkom terapijom c 77% (78/102)
English: Never re-use a syringe, for your safety and health and for the safety of others.
Croatian: Nikada ne upotrebljavajte već upotrijebljene štrcaljke zbog vlastite sigurnosti i zdravlja te zbog sigurnosti drugih.
English: The solution is clear to slightly opalescent, colourless to light yellow and may contain a few small translucent or white particles of protein.
Croatian: Otopina je bistra do blago opalescentna, bezbojna do svijetložuta i može sadržavati nekoliko malih prozirnih ili bijelih čestica proteina.
English: Patients with each subtype of PsA were enrolled, including polyarticular arthritis with no evidence of rheumatoid nodules (39%), spondylitis with peripheral arthritis (28%), asymmetric peripheral arthritis (21%), distal interphalangeal involvement (12%) and arthritis mutilans (0.5%).
Croatian: Uključeni su bolesnici svih podskupina PsA, uključujući poliartikularni artritis bez prisustva reumatoidnih nodula (39%), spondilitis sa perifernim artritisom (28%), asimetrični periferni artritis (21%), distalnu interfalangealnu zahvaćenost (12%), te artritis mutilans (0,5%).
English: What you need to know before you use Stelara
Croatian: Što morate znati prije nego počnete primjenjivati Stelaru
English: • It is preferable to avoid the use of Stelara in pregnancy.
Croatian: • Preporučuje se izbjegavati primjenu Stelare u trudnoći.
English: Patients who were in 100 point clinical response to ustekinumab at start of maintenance therapy Patients who failed conventional therapy but not anti-TNFα therapy Patients who are anti-TNFα refractory/intolerant p < 0.01 p < 0.05 nominally significant (p < 0.05)
Croatian: Bolesnici koji su imali klinički odgovor na ustekinumab od 100 bodova na početku terapije održavanja Bolesnici u kojih je konvencinalna terapija bila neuspješna, ali ne i anti-TNFα terapija Bolesnici koji su refraktorni/netolerantni na anti-TNFα terapiju p < 0,01 p < 0,05 nominalno značajno (p < 0,05)
English: In the treatment regimen, the first dose of STELARA is administered intravenously.
Croatian: U režimu liječenja, prva doza STELARE se primjenjuje intravenski.
English: Loss of response was defined as a CDAI score ≥ 220 points and a ≥ 100 point increase from the CDAI score at baseline.
Croatian: Gubitak odgovora bio je definiran kao CDAI skor ≥ 220 bodova i povećanje ≥ 100 bodova u odnosu na CDAI skor na početku.
English: Carcinogenicity studies were not performed with ustekinumab due to the lack of appropriate models for an antibody with no cross-reactivity to rodent IL-12/23 p40.
Croatian: Ispitivanja kancerogenosti nisu provedena s ustekinumabom zbog nedostatka odgovarajućih modela za protutijela bez križne reaktivnosti na IL-12/23 p40 glodavaca.
English: • Psoriatic arthritis - in adults
Croatian: • Psorijatični artritis - u odraslih
English: Animal studies have shown excretion of ustekinumab at low levels in breast milk.
Croatian: Ispitivanja na životinjama pokazala su izlučivanje ustekinumaba u malim količinama u majčinom mlijeku.
English: Clinical presentations included cough, dyspnoea, and interstitial infiltrates following one to three doses.
Croatian: Klinička manifestacija je uključivala kašalj, dispneju i intersticijske infiltrate nakon jedne do tri doze.
English: Enrolled patients had to have failed conventional therapy (corticosteroids or immunomodulators) or at least one biologic (a TNFα antagonist and/or vedolizumab).
Croatian: Uključeni bolesnici morali su prethodno biti neuspješno liječeni konvencionalnom terapijom (kortikosteroidima ili imunomodulatorima) ili najmanje jednim biološkim lijekom (antagonistom TNFα i/ili vedolizumabom).
English: Patients may subsequently be dosed every 8 weeks or every 12 weeks according to clinical judgment (see section 5.1).
Croatian: Naknadno se bolesnicima može dati doza svakih 8 tjedana ili svakih 12 tjedana sukladno kliničkoj procjeni (vidjeti dio 5.1).
English: Concomitant doses of oral corticosteroids, immunomodulators, aminosalicylates and antibiotics were permitted and 75% of patients continued to receive at least one of these medications.
Croatian: Istodobne doze oralnih kortikosteroida, imunomodulatora, aminosalicilata i antibiotika bile su dozvoljene i 75% bolesnika nastavilo je primati barem jedan od tih lijekova.
English: What Stelara is and what it is used for What you need to know before you use Stelara How Stelara will be given Possible side effects
Croatian: Što je Stelara i za što se koristi Što morate znati prije nego počnete primjenjivati Stelaru Kako će Vam Stelara biti primijenjena Moguće nuspojave
English: If this happens, you will get training on how to inject Stelara.
Croatian: Ako dođe do toga, podučit će Vas kako si dati injekciju Stelare.
English: STELARA is available in a 1 vial pack.
Croatian: STELARA je dostupna u pakiranju sa 1 bočicom.
English: > 55 kg to ≤ 85 kg
Croatian: > 55 kg do ≤ 85 kg
English: Patients receiving STELARA may receive concurrent inactivated or non-live vaccinations.
Croatian: Bolesnici koji primaju STELARU mogu istovremeno primiti inaktivirano ili neživo cjepivo.
English: The first study was in 110 patients from 12 to 17 years of age treated for up to 60 weeks and the second study was in 44 patients from 6 to 11 years of age treated for up to 56 weeks.
Croatian: Prvo je ispitivanje obuhvatilo 110 bolesnika u dobi od 12 do 17 godina koji su bili liječeni tijekom do 60 tjedana, dok je drugo ispitivanje provedeno u 44 bolesnika u dobi od 6 do 11 godina koji su bili liječeni tijekom do 56 tjedana.
English: Stelara 130 mg concentrate for solution for infusion will be given to you by your doctor, through a drip in the vein of your arm (intravenous infusion) over at least one hour.
Croatian: Stelara 130 mg koncentrat za otopinu za infuziju primijenit će Vam liječnik, putem infuzije kap po kap (drip) u venu ruke (infuzija u venu) tijekom najmanje jednog sata.
English: Use only an infusion set with an in-line, sterile, non-pyrogenic, low protein-binding filter (pore size 0.2 micrometer).
Croatian: Koristite isključivo infuzijski set s linijskim, sterilnim, ne-pirogenim filterom sa slabim afinitetom vezanja proteina (veličina pora 0,2 mikrometra).
English: In a population pharmacokinetic analysis, the apparent clearance (CL/F) and apparent volume of distribution (V/F) were 0.465 l/day and 15.7 l, respectively, in patients with psoriasis.
Croatian: U farmakokinetičkoj analizi populacije, prividan klirens (CL/F) i prividan volumen distribucije (V/F) bili su 0,465 l/dan odnosno 15,7 l, kod bolesnika s psorijazom.
English: In general, the adverse events reported in these two studies with safety data up to 1 year were similar to those seen in previous studies in adults with plaque psoriasis.
Croatian: Štetni događaji prijavljeni u tim dvama ispitivanjima, iz kojih su dostupni podaci o sigurnosti prikupljeni tijekom razdoblja do godine dana, u načelu su bili slični onima zabilježenima u prethodnim ispitivanjima kod odraslih bolesnika s plak psorijazom.
English: In patients with Crohn's disease and ulcerative colitis, treatment with ustekinumab resulted in a decrease in inflammatory markers including C-Reactive Protein (CRP) and fecal calprotectin during the induction phase, which were then maintained throughout the maintenance phase.
Croatian: U bolesnika s Crohnovom bolesti i ulceroznim kolitisom, liječenje ustekinumabom rezultiralo je smanjenjem upalnih markera uključujući C-Reaktivni Protein (CRP) i fekalnog kalprotektina tijekom faze uvođenja, što se zatim održalo tijekom faze održavanja.
English: The impact of these covariates was within ±20% of the typical or reference value of the respective PK parameter, thus dose adjustment is not warranted for these covariates.
Croatian: Utjecaj navedenih kovarijati bio je unutar ± 20% tipičnih ili referentnih vrijednosti za odgovarajuće farmakokinetičke parametre; stoga nije potrebno prilagođavati dozu s obzirom na te kovarijate.
English: A TNFα antagonist and/or vedolizumab.
Croatian: Antagonist TNFα i/ilivedolizumab.
English: Signs include: o difficulty breathing or swallowing o low blood pressure, which can cause dizziness or light-headedness o swelling of the face, lips, mouth or throat.
Croatian: Znakovi uključuju: o poteškoće s disanjem ili gutanjem o nizak krvni tlak, koji može izazvati omaglicu ili ošamućenost o oticanje lica, usana, ustiju ili grla.
English: Improvements in PGA, PASI, CDLQI and PedsQL were maintained through week 52 (Table 7).
Croatian: Poboljšanja u PGA, PASI, CDLQI i PedsQL održana su kroz 52. tjedan (Tablica 7).
English: In clinical studies, patients with latent tuberculosis who were concurrently treated with isoniazid did not develop tuberculosis.
Croatian: U kliničkim ispitivanjima, kod bolesnika s latentnom tuberkulozom koji su istovremeno liječeni izoniazidom, tuberkuloza se nije pojavila.
English: Alternatively, 90 mg may be used in patients with a body weight > 100 kg.
Croatian: Alternativno, doza od 90 mg može biti primijenjena kod bolesnika čija je tjelesna težina > 100 kg.
English: Median volume of distribution during the terminal phase (Vz) following a single intravenous administration to patients with psoriasis ranged from 57 to 83 mL/kg.
Croatian: Medijan volumena distribucije tijekom terminalne faze (Vz) nakon jedne intravenske primjene kod bolesnika s psorijazom kretao se od 57 do 83 ml/kg.
English: Check the number of vials and prepare the materials:
Croatian: Provjerite količinu bočica i pripremite pribor:
English: These medicines work by weakening part of the immune system.
Croatian: Ti lijekovi djeluju tako da oslabljuju dio imunološkog sustava.