FrancophonIA/ELRC3.0 huggingface dataset:
English: In a study of healthy volunteers, coadministration of felbamate (1200 mg twice daily) with lamotrigine (100 mg twice daily for 10 days) appeared to have no clinically relevant effects on the pharmacokinetics of lamotrigine.
Maltese: Fi studju fuq voluntieri f'saħħithom, it-teħid flimkien ta' felbamate (1200 mg darbtejn kuljum) ma' lamotrigine (100 mg darbtejn kuljum għal 10 ġranet) ma deher li kellu ebda effetti rilevanti kliniċi fuq ilfarmakokinetiċi ta' lamotrigine.
English: Each tablet contains 25 mg, 50 mg, 100 mg or 200 mg lamotrigine.
Maltese: Kull pilola fiha 25 mg, 50 mg, 100 mg jew 200 mg lamotrigine.
English: Although the number of suicidal ideation and behaviour events was too low (6/1073 [0.6%] on lamotrigine and 2/805 [0.3%] on placebo) to allow a definitive comparison between treatment groups, the relative rate reported from this lamotrigine analysis is consistent with the reported class effect for AEDs (see section 4.4).
Maltese: Għalkemm in-numru ta' ideazzjoni suwiċidali u eventi li jinvolvu l-aġir kienu baxxi wisq (6/1073 [0.6%] fuq lamotrigine u 2/805 [0.3%] fuq plaċebo) biex iħallu tqabbil definittiv bejn il-gruppi ta' kura, ir-rata relattiva irrapurtata minn din l-analiżi ta' lamotrigine hija konsistenti ma' leffett ta' klassi irrapurtat għall-AED (ara s-sezzjoni 4.4).
English: nausea, vomiting, diarrhoea.
Maltese: panċitopenija, anemija aplastika, agranuloċitożi.
English: Musculoskeletal and connective tissue disorders Very rare:
Maltese: Disturbi muskulo-skeletriċi u tal-connective tissue Rari ħafna:
English: agitation, unsteadiness, movement disorders, worsening of Parkinson's disease, extrapyramidal effects, choreoathetosis, increase in seizure frequency.
Maltese: aġitazzjoni, nuqqas ta' stabbilita', disturbi tal-moviment, peġġjorament tal-marda Parkinson, effetti strapiramidali, koreoatetożi, żjieda fil-frekwenza ta' aċċessjonijiet.
English: Each Lamictal 200 mg tablet contains 200 mg lamotrigine.
Maltese: Kull pillola Lamictal 200 mg fiha 200 mg lamotrigine.
English: Lamictal 200 mg tablets are marked ‘GSEE7' on one side and ‘200' on the other.
Maltese: Il-pilloli Lamictal tal-200 mg huma mmarkati ‘GSEE7' fuq naħa waħda u ‘200' fuq in-naħa l-oħra.
English: Multiple oral doses of lamotrigine 400 mg daily had no clinically significant effect on the single dose pharmacokinetics of 2 mg risperidone in 14 healthy adult volunteers.
Maltese: Numru ta' dożi orali ta' 400 mg lamotrigine kuljum ma kellu ebda effett sinifikanti kliniku fuq ilfarmakokinetiċi ta' doża waħda ta' 2 mg risperidone f'14 voluntieri f'saħħithom.
English: Once stabilised using lamotrigine monotherapy or adjunctive therapy, patients were randomly assigned into one of five treatment groups: lamotrigine (50, 200, 400 mg/day), lithium (serum levels of 0.8 to 1.1 mMol/L) or placebo for a maximum of 76 weeks (18 months).
Maltese: La darba stabbiliti b'monoterapija b'lamotrigine jew terapija aġġuntiva, il-pazjenti ġew imqassma bl-addoċċ f'wieħed mill-ħames gruppi ta' kura: lamotrigine (50, 200, 400mg/kuljum, lithium (livelli fis-serum ta' 0.8 sa 1.1 mMol/L) jew plaċebo għal massimu ta' 76 ġimgħa (18-il xahar).
English: The usual effective dose of Lamictal for adults and children aged over 12 years is between 100 mg and 400 mg each day.
Maltese: Id-doża effettiva normali ta' Lamictal għal adulti u tfal ta' fuq it12-il sena hi ta' bejn 100 mg u 400 mg kuljum.
English: In six volunteers with kidney failure, 20% of the lamotrigine was removed from the body during a 4-hour haemodialysis session (see section 5.2).
Maltese: F'sitt voluntieri f'saħħithom li kellhom indeboliment tal-kliewi , tneħħa 20% ta' lamotrigine mill-ġisem waqt sessjoni ta' 4 sigħat emodijalisi (ara sezzjoni 5.2).
English: The primary endpoint was "Time to Intervention for a Mood Episode (TIME)", where the interventions were additional pharmacotherapy or electroconvulsive therapy (ECT).
Maltese: L-endpoint primarju kien "Żmien għal Intervent għal Episodu ta' Bdil fil-Burdata (TIME)", fejn l-interventi kienu farmakoterapija addizzjonali jew terapija elettrokonvulżiva (ECT).
English: Interactions involving hormonal contraceptives
Maltese: Interazzjonijiet li jinvolvu kontraċettivi ormonali
English: In double-blind, adjunctive clinical trials in adults, skin rashes occurred in up to 10% of patients taking lamotrigine and in 5% of patients taking placebo.
Maltese: Fi provi kliniċi addizzjonali u double-blind fuq adulti, żviluppaw każijiet ta' raxx fil-ġilda sa fuq 10% ta' pazjenti li kienu jieħdu lamotrigine u sa fuq 5% f'pazjenti fuq plaċebo.
English: Effects of lamotrigine on hormonal contraceptive efficacy An interaction study in 16 healthy volunteers has shown that when lamotrigine and a hormonal contraceptive (ethinyloestradiol/levonorgestrel combination) are administered in combination, there is a modest increase in levonorgestrel clearance and changes in serum FSH and LH (see section 4.5).
Maltese: Studju dwar interazzjoni f'16-il voluntier f'saħħithom wera li meta lamotrigine u kontraċettiv ormonali (kombinazzjoni ethinyloestradiol/levonorgestrel) jingħataw flimkien, ikun hemm żjieda żgħira fit-tneħħija ta' levonorgestrel u bidliet fis-serum FSH u LH (ara sezzjoni 4.5).
English: 25, 50, 100 and 200 mg tablets: Excipient of Lamictal tablets
Maltese: Pilloli ta' 25, 50, 100 u 200 mg: Sustanzi mhux attivi fil-pilloli Lamictal
English: Effects of hormonal contraceptives on lamotrigine efficacy The use of an ethinyloestradiol/levonorgestrel (30 µg/150 µg) combination increases the clearance of lamotrigine by approximately two-fold resulting in decreased lamotrigine levels (see section 4.5).
Maltese: Effetti ta' kontraċettivi ormonali fuq l-effikaċja ta' lamotrigine L-użu ta' kombinazzjoni ta' ethinyloestradiol/levonorgestrel (30 µg/150 µg) iżid it-tneħħija ta' lamotrigine bid-doppju bir-riżultat ta' livelli aktar baxxi ta' lamotrigine (ara sezzjoni 4.5).
English: Lamictal and associated names (see Annex I) 25 mg tablets Lamictal and associated names (see Annex I) 50 mg tablets Lamictal and associated names (see Annex I) 100 mg tablets Lamictal and associated names (see Annex I) 200 mg tablets Lamictal and associated names (see Annex I) 2 mg dispersible/chewable tablets Lamictal and associated names (see Annex I) 5 mg dispersible/chewable tablets Lamictal and associated names (see Annex I) 25 mg dispersible/chewable tablets Lamictal and associated names (see Annex I) 50 mg dispersible/chewable tablets Lamictal and associated names (see Annex I) 100 mg dispersible/chewable tablets Lamictal and associated names (see Annex I) 200 mg dispersible/chewable tablets
Maltese: Kull pillola Lamictal 2 mg li tixtered/tiġi mimgħuda fiha 2 mg lamotrigine Kull pillola Lamictal 5 mg li tixtered/tiġi mimgħuda fiha 5 mg lamotrigine Kull pillola Lamictal 25 mg li tixtered/tiġi mimgħuda fiha 25 mg lamotrigine Kull pillola Lamictal 50 mg li tixtered/tiġi mimgħuda fiha 50 mg lamotrigine Kull pillola Lamictal 100 mg li tixtered/tiġi mimgħuda fiha 100 mg lamotrigine Kull pillola Lamictal 200 mg li tixtered/tiġi mimgħuda fiha 200 mg lamotrigine
English: The syndrome shows a wide spectrum of clinical severity and may, rarely, lead to disseminated intravascular coagulation and multiorgan failure.
Maltese: Is-sindrome turi firxa wiesgħa ta' severita' klinika u, rarament, tista' twassal għal koagulazzjoni intravaskulari mxerrda u ħsara f'diversi organi tal-ġisem.
English: The incidence of suicidal ideation and behaviour was evaluated in a pooled analysis of placebo-controlled clinical trials with lamotrigine involving a total of 6467 patients from a number of indications.
Maltese: l-inċidenza ta' ideazzjoni u aġir suwiċidali kienet evalwata f'analiżi miġbura flimkien ta' studji kliniċi kkontrollati bi plaċebo b'lamotrigine li fihom kienu involuti total ta' 6467 pazjent minn numru ta' indikazzjonijiet.
English: For children aged 2 to 12 years, the effective dose depends on their body weight - usually, it's between 1 mg and 15 mg for each kilogram of the child's weight, up to a maximum of 400 mg daily.
Maltese: Fil-każ ta' tfal bejn sentejn u 12-il sena, id-doża effettiva tiddependi mill-piż tal-ġisem - normalment din tkun bejn 1 mg u 15 mg għal kull kilogramm li tiżen it-tarbija, sa massimu ta' 400 mg kuljum.
English: • rapid, uncontrollable eye movements (nystagmus)
Maltese: • movimenti mgħaġġla u bla kontroll ta' l-għajnejn (nistagmus)
English: 400 mg/day
Maltese: 400 mg/kuljum
English: The group concurred that theoretically a mood stabiliser should be able to prevent both manic and depressive recurrences, the characteristic features of Bipolar Disorder, but as of now we do not possess such an ideal mood stabiliser.
Maltese: Il-grupp irraġuna li teorikament stabilizzatur tal-burdata għandu jkun kapaċi jipprevjeni kemm episodji ta' manija kif ukoll dawk depressivi, li huma karatteristiċi tad-disturb bipolari, iżda sa issa stabilizzatur talburdata ideali mhuwiex disponibbli.
English: • carbamazepine, used to treat epilepsy and mental health problems
Maltese: • carabamazepine, li jintuża fil-kura ta' l-epilessija u fi problemi ta' saħħa mentali
English: 0.3 mg/kg/day (once a day)
Maltese: 0.3 mg/kg/kulj um (darba kuljum)
English: Excipient: Each tablet contains 93.9 mg lactose.
Maltese: Kull pillola fiha 93.9 mg lattosju.
English: • valproate, used to treat epilepsy and mental health problems
Maltese: • valproate, li jintuża fil-kura ta' l-epilessija u fi problemi ta' saħħa mentali
English: In patients receiving concomitant therapy with phenytoin, carbamazepine, pheonbarbitone or primidone, the appropriate treatment regimen should be used (see section 4.2).
Maltese: F'pazjenti fuq terapija konkomitanti ta' phenytoin, carbamazepine, phenobarbitone u primidone, għandu jiġi wżat il-programm xieraq ta' trattament (ara sezzjoni 4.2).
English: 1.2 mg/kg/day (two divided doses)
Maltese: 1.2 mg/kg/kulj um (żewġ dożi maqsuma)
English: • changes which may show up in blood tests - including reduced numbers of red blood cells (anaemia), reduced numbers of white blood cells (leucopenia, neutropenia, agranulo-cytosis), reduced numbers of platelets (thrombocytopenia), reduced numbers of all these types of cell (pancytopenia), and a disorder of the bone marrow called aplastic anaemia
Maltese: • tibdiliet li jistgħu jidhru f'testijiet tad-demm - fosthom nuqqas fin-numru ta' ċelluli ħomor taddemm (anemija), nuqqas fin-numru ta' ċelluli bojod tad-demm (lewkopenija, newtropenija,agranulo-ċitożi), nuqqas fin-numru ta' platelets (tromboċitopenija), nuqqas fin-numru ta' dawn it-tipi kollha ta' ċelluli (panċitopenija), u mard fil-mudullun imsejjaħ anemija aplastika
English: Hepato-biliary disorders Very rare:
Maltese: Disturbi fil-fwied u fil-marrara Rari ħafna:
English: Lamotrigine (the active substance of Lamictal) is a well-known anti-epileptic agent approved for the treatment of epileptic seizures in most EU-member states on a National basis.
Maltese: Lamotriġina (lamotrigine - is-sustanza attiva ta' Lamictal) hija aġent antiepilettiku magħruf approvat għattrattament ta' kriżijiet epilettiċi f'ħafna mill-Istati Membri ta' l-UE fuq skala nazzjonali.
English: Each Lamictal 100 mg tablet contains 100 mg lamotrigine.
Maltese: Kull pillola Lamictal 100 mg fiha 100 mg lamotrigine.
English: They are marked ‘GSCL7' on one side; and ‘100' on the other.
Maltese: Huma mmarkati ‘GSCL7' fuq naħa waħda; u ‘100' fuq in-naħa l-oħra.
English: • risperidone, used to treat mental health problems
Maltese: • risperidone, li jintuża fil-kura ta' problemi ta' saħħa mentali
English: PVC/aluminium foil blister.
Maltese: Folja blister tal-PVC/aluminju.
English: • phenytoin, primidone or phenobarbitone, used to treat epilepsy
Maltese: • phenytoin, primidone jew phenobarbitone, li jintużaw fil-kura ta' l-epilessija
English: Efficacy as monotherapy treatment of typical absence seizures was demonstrated.
Maltese: Intweriet effikaċja bħala trattament monoterapewtiku tal-kriżi ta' assenza tipika (typical absence seizures).
English: They are marked ‘GSEC5' on one side; and ‘200' on the other.
Maltese: Huma mmarkati ‘GSEC5' fuq naħa waħda; u ‘200' fuq in-naħa l-oħra.
English: Treatment was initiated in 177 subjects, with a dose titration schedule similar to that of children aged 2 to 12 years.
Maltese: Inbdiet il-kura f'177 suġġett bi skeda ta' titrazzjoni tad-doża simili ta' dik fi tfal ta' bejn is-2 u t-12-il sena.
English: 0.6 mg/kg/day (two divided doses)
Maltese: 0.6 mg/kg/kulju m (żewġ dożi maqsuma)
English: (Starter pack 42 tablets, monotherapy - calender pack showing day numbers): 1 2 3 4 5 6 7 (one pocket)
Maltese: (Pakkett tal-bidu 42 tablets, monoterapija - pakkett kalendarju li juri n-numru ta' ġranet): 1 2 3 4 5 6 7 (kontenitur wieħed)
English: A meta-analysis of placebo-controlled trials of AEDs (including lamotrigine) showed an increased risk of suicidal behaviour (see section 5.1).
Maltese: Meta-analiżi ta' studji kliniċi, kkontrollati bi plaċebo, ta' AED (fosthom lamotrigine) urew riskju akbar ta' aġir ta' suwiċidju (ara sezzjoni 5.1).
English: Starter pack of 42 tablets.
Maltese: Pakkett ta' 42 pilloli biex tibda bih.
English: The mean half-life was estimated at 23 hours in infants younger than 26 months on enzyme-inducing therapy, 136 hours when co-administered with valproate and 38 hours in subjects treated without enzyme inducers/inhibitors.
Maltese: Il-medja ta' half-life kienet stimata għal 23 siegħa fi trabi iżgħar minn 26 xahar fuq terapija li tinduċi l-enżimi, 136 siegħa meta ingħatat flimkien ma' valproate u 38 siegħa f'suġġetti trattati mingħajr indutturi/inibituri ta' l-enżimi.
English: The half-life of lamotrigine is generally shorter in children than in adults with a mean value of approximately 7 hours when given with enzyme-inducing medicinal products such as carbamazepine and phenytoin and increasing to mean values of 45 to 50 hours when co-administered with valproate alone (see section 4.2).
Maltese: Il-half-life ta' lamotrigine hi ġeneralment iqsar fit-tfal milli fil-kbar b'valur medju ta' madwar 7 sigħat meta mogħti ma' prodotti mediċinali li jinduċu enzimi bħal carbamazepine u phenytoin u tiżdied għal valuri medji ta' 45 sa 50 siegħa meta mogħti flimkien ma' valproate waħdu (ara sezzjoni 4.2).
English: In a study in healthy volunteers, lopinavir/ritonavir approximately halved the plasma concentrations of lamotrigine, probably by induction of glucuronidation.
Maltese: Fi studju fuq voluntieri f'saħħithom, lopinavir/ritonavir naqqsu b'madwar in-nofs il-konċentrazzjonijiet ta' plasma ta' lamotrigine, probabbilment bl-induzzjoni ta' glukuronidazzjoni.
English: • uncontrollable body movements (tics), uncontrollable muscle spasms affecting the eyes, head and torso (choreoathetosis), or other unusual body movements such as jerking, shaking or stiffness
Maltese: • movimenti bla kontroll tal-ġisem (liwi involontarju), spażmi mhux kontrollati li jaffettwaw lgħajnejn, ir-ras u t-torso (koreoatetożi), jew movimenti oħra mhux normali tal-ġisem bħal skossi, rogħda jew ebusija.
English: 300 mg/day
Maltese: 300 mg/kuljum
English: Therefore, consideration should be given to using contraception without a pill-free week, as first-line therapy (for example, continuous hormonal contraceptives or non-hormonal methods; see sections 4.4 and 4.5).
Maltese: Għalhekk, għandu jiġi kkunsidrat l-użu ta' kontraċezzjoni mingħajr ma titwaqqaf il-pillola għal ġimgħa, bħala kura prinċipali (per eżempju, kontraċettivi ormonali kontinwi jew metodi mhux ormonali ; ara s-sezzjonijiet 4.4 u 4.5).
English: The other ingredients are: lactose monohydrate, microcrystalline cellulose, povidone K30, sodium starch glycolate (Type A), iron oxide yellow (E172) and magnesium stearate.
Maltese: L-ingredjenti l-oħra huma: monoidrat tal-lattosju, ċellulosju mikrokristallin, providone K30, sodium starch glycolate (Tip A), ossidu isfar tal-ħadid (E172) u stearat tal-manjesju.
English: Lamictal 100 mg tablets are marked ‘GSEE5' on one side and ‘100' on the other.
Maltese: Il-pilloli Lamictal tal-100 mg huma mmarkati ‘GSEE5' fuq naħa waħda u ‘100' fuq in-naħa l-oħra.
English: If epileptic control is achieved with adjunctive treatment, concomitant AEDs may be withdrawn and patients continued on Lamictal monotherapy.
Maltese: Jekk jinkiseb kontroll epilettiku flimkien ma' trattament addizzjonali, AEDs konkomitanti jistgħu jitwaqqfu u l-pazjenti jistgħu ikomplu b'monoterapija ta' Lamictal.
English: Lamotrigine at 200 mg did not affect the pharmacokinetics of olanzapine.
Maltese: Lamotrigine b'doża ta' 200 mg ma kellu ebda effett fuq il-farmakokinetiċi ta' olanzapine.
English: The most frequently reported defects are cleft lip, cardiovascular malformations and neural tube defects.
Maltese: Id-difetti l-aktar rappurtati ta' spiss huma cleft lip, malformazzjonijiet kardjo-vaskulari u difetti fit-tubu nevralġiku.
English: 25 mg Tablet
Maltese: 25 mg Pillola
English: - high initial doses of lamotrigine and exceeding the recommended dose escalation of lamotrigine therapy (see section 4.2) - concomitant use of valproate (see section 4.2).
Maltese: - dożi qawwija ta' lamotrigine fil-bidu li jeċċedu ż-żidiet rakkomandati fit-terapija b'lamotrigine (ara sezzjoni 4.2) - l-użu ta' valproate fl-istess ħin (ara sezzjoni 4.2).
English: Interactions involving antiepileptic drugs
Maltese: Interazzjonijiet li jinvolvu mediċini anti-epilettiċi
English: Packs of 30, 50, 56, 60, 90 or 100 tablets.
Maltese: Pakketti ta' 30, 50, 56, 60, 90 jew 100 pillola.
English: Withdrawal of inducers of lamotrigine glucuronidation (see section 4.5), depending on original dose of lamotrigine:
Maltese: Meta jitwaqqfu indutturi ta' glukuronidazzjoni ta' lamotrigine (ara sezzjoni 4.5), skond id-doża oriġinali ta' lamotrigine:
English: Study SCAB2003 was a multicentre, double-blind, double dummy, placebo and lithium-controlled, randomised fixed dose evaluation of the long-term prevention of relapse and recurrence of depression and/or mania in patients with bipolar I disorder who had recently or were currently experiencing a major depressive episode.
Maltese: L-istudju SCAB2003 kien f'aktar minn ċentru wieħed, double-blind, double dummy, ikkontrollat bi plaċebo u lithium, intagħżel bl-addoċċ l-evalwazzjoni tad-doża fissa għal prevenzjoni fit-tul ta' rkadenza u rikorrenza ta' dipressjoni u/jew mania f'pazjenti b'disturb bi-polari I li kellhom riċentement jew kienu qed jesperjenzaw episodju ta' dipressjoni maġġuri.
English: Infants aged 2 to 26 months
Maltese: Trabi ta' bejn 2 u 26 xahar
English: Maintain target dose achieved in dose escalation (200 mg/day; dose range 100-400 mg/day)
Maltese: Żomm id-doża fil-mira miksuba fiż-żjieda tad-doża (200 mg/kuljum; skala ta' doża 100-400 mg/kuljum
English: The pharmacokinetics of lithium after 2 g of anhydrous lithium gluconate given twice daily for six days to 20 healthy subjects were not altered by co-administration of 100 mg/day lamotrigine.
Maltese: Il-farmakokinetiċi ta' litju wara 2g ta' anhydrous lithium gluconate mogħti darbtejn kuljum għal sitt ijiem lil 20 individwi f'saħħithom ma nbidlux bl-għoti flimkien ta' 100 mg/kuljum lamotrigine.
English: GlaxoSmithKline (Ireland) Ltd Stonemasons Way Rathfarnham
Maltese: GlaxoSmithKline (Ireland) Ltd
English: There have been reports of central nervous system events including dizziness, ataxia, diplopia, blurred vision and nausea in patients taking carbamazepine following the introduction of lamotrigine.
Maltese: Kien hemm xi rapporti ta' reazzjonijiet fis-sistema nervuża ċentrali fosthom sturdamenti, atassija, diplopija, vista mċajpra u dardir f'pazjenti li ħadu carbamazepine wara li bdew lamotrigine.
English: 5 mg dispersible/chewable tablets - where 2 mg dispersible/chewable tablets are not marketed and 5 mg dispersible/chewable tablets are the lowest marketed strength: <It should be noted that with the currently available Lamictal 5 mg dispersible/chewable tablet strength, it is not possible to accurately initiate lamotrigine therapy using the recommended dosing guidelines in paediatric patients weighing less than 17 kg.>
Maltese: <Għandu jiġi nnotat li bil-pilloli li jixterdu/jiġu mimgħuda Lamictal ta' 5 mg li jinsabu fis-suq bħalissa, mhux possibbli li tinbeda terapija ta' lamotrigine bl-użu tal-linji gwida dwar dożaġġi rakkomandati f'pazjenti pedjatriċi li jiżnu inqas minn 17 kg.>
English: 200 mg/day Maintain this dose (200 mg/day) Addition of inducers of lamotrigine glucuronidation in patients NOT taking valproate (see section 4.5), depending on original dose of lamotrigine: 200 mg/day
Maltese: Żomm din id-doża (200 mg/kuljum) Żjieda ta' indutturi ta' glukuronidazzjoni ta' lamotrigine f'pazjenti li MA JKUNUX jieħdu valproate (ara sezzjoni 4.5), skond id-doża oriġinali ta' lamotrigine: 200 mg/kuljum 200 mg/kul jum
English: In the subset of epilepsy trials, there were no statistically significant differences in the rate of events between lamotrigine and placebo.
Maltese: Fis-subset ta' studji kliniċi ta' epilessija, ma kienx hemm differennzi statistikament sinifikanti fir-rati ta' eventi bejn lamotrigine u plaċebo.
English: Lennox-Gastaut Syndrome is a difficult to treat condition and monotherapy is rarely achieved.
Maltese: Is-Sindromu Lennox-Gastaut huwa kundizzjoni li diffiċli biex tiġi ttrattata u rarament tintlaħaq b'monoterapija.
English: If you have bipolar disorder, you may be more likely to think like this:
Maltese: Jekk għandek disturb bi-polari, jista' jkun aktar possibli li taħseb hekk:
English: The results of pharmacological studies suggest that lamotrigine is a use- and voltage-dependent blocker of voltage gated sodium channels.
Maltese: Ir-riżultati minn studji farmakoloġiċi jindikaw li lamotrigine hu imblokkatur dipendenti minn użu u voltaġġ ta' kanali tas-sodju voltage gated.
English: Rash has also been reported as part of a hypersensitivity syndrome associated with a variable pattern of systemic symptoms including fever, lymphadenopathy, facial oedema and abnormalities of the blood and liver (see section 4.8).
Maltese: Raxx ġie wkoll rappurtat bħala parti ta' sindrome ta' sensittivita' eċċessiva assoċjata ma' għamla varjata ta' sintomi sistemiċi li jinkludu deni, limfadenopatija, edema fil-wiċċ u anormalitajiet fid-demm u l-fwied (ara sezzjoni 4.8).
English: Whereas, in controlled clinical trials with bipolar disorder patients, skin rashes occurred in 8% of patients taking lamotrigine and in 6% of patients taking placebo.
Maltese: Waqt li,fi provi kliniċi kontrollati fuq pazjenti b'mard bi-polari, raxx fil-ġilda seħħ fi 8% ta' pazjenti fuq lamotrigine u f'6% ta' pazjenti fuq plaċebo.
English: Packs of 14, 21, 30, 42, 50, 56 or 100 tablets.
Maltese: Pakketti ta' 14, 21, 30, 42, 50, 56 jew 100 pilloli.
English: 25, 50, 100 and 200 mg tablets, 5, 25, 50, 100 and 200 mg dispersible/chewable tablets: Three years.
Maltese: 2, 5, 25, 50, 100 u 200 mg pilloli li jixterdu/jiġu mimgħuda:
English: (Starter pack 42 tablets, non-valproate add-on therapy - calender pack showing day numbers): 1 2 3 4 5 6 7 (1 pocket)
Maltese: (Pakkett biex tibda ta' 42 tablets, valproate terapija add-on - pakkett kalendarju li juri n-numru ta' ġranet): 1 2 3 4 5 6 7 (kontenitur wieħed)
English: Adults and adolescents aged 13 years and above - Adjunctive or monotherapy treatment of partial seizures and generalised seizures, including tonic-clonic seizures.
Maltese: Adulti u adolexxenti minn 13-il sena 'l fuq - It-trattament aġġuntiv jew monoterapewtiku tal-kriżijiet parzjali u tal-kriżijiet ġeneralizzati, inklużi l-kriżijiet toniko-kloniċi.
English: The risk of congenital malformations is increased by a factor of 2 to 3 in the offspring of mothers treated with AEDs compared with the expected incidence in the general population of approximately 3%.
Maltese: Ir-riskju ta' malformazzjonijiet konġenitali jiżdied b'fattur ta' 2 sa 3 fil-wild ta' ommijiet trattati b'AEDs meta mqabbel ma' l-inċidenza mistennija ta' 3% fil-popolazzjoni ġenerali.
English: Lamictal is not indicated for the acute treatment of manic or depressive episodes.
Maltese: Lamictal m'għandux jintuża għat-trattament akut ta' episodji manijaċi dew depressivi.
English: Some medicines interact with Lamictal or make it more likely that you'll have side effects.
Maltese: Xi mediċini ma jaqblux ma' Lamictal jew iżidu l-probabbilta' ta' effetti sekondarji.