FrancophonIA/ELRC3.0 huggingface dataset:
English: Your doctor should do a blood test to check your kidney function before each dose of Aclasta.
Slovenian: Zdravnik mora pred vsakim odmerjanjem zdravila Aclasta s krvnimi preiskavami pregledati delovanje vaših ledvic.
English: Placebo (N=1,062) event rate
Slovenian: Aclasta (N=1.065) delež dogodkov placebo (N=1.062) delež dogodkov absolutno znižanje deleža zlomov % (IZ)
English: In the HORIZON-RFT study Aclasta treatment significantly increased BMD at the total hip and femoral neck relative to treatment with placebo at all timepoints.
Slovenian: Učinek na mineralno gostoto kosti (bone mineral density - BMD) V študiji HORIZON-RFT je zdravljenje z zdravilom Aclasta ob vseh časih opazovanja pomembno povečalo mineralno gostoto kosti celotnega kolka in vratu stegnenice v primerjavi s placebom.
English: Absolute reduction in fracture incidence % (CI)
Slovenian: Aclasta placebo absolutno znižanje odstotka zlomov % (IZ)
English: Class effects
Slovenian: Učinki po skupinah
English: In addition, in patients with Paget's disease, it is strongly advised that adequate supplemental calcium corresponding to at least 500 mg elemental calcium twice daily is ensured for at least 10 days following Aclasta administration (see section 4.2).
Slovenian: Skupaj z dajanjem zdravila Aclasta je priporočeno zadostno uživanje kalcija in vitamina D. Poleg tega je bolnikom s Pagetovo boleznijo zelo priporočljivo zagotoviti zadostno dodajanje kalcija, ki ustreza vsaj 500 mg elementarnega kalcija, dvakrat na dan vsaj 10 dni po uporabi zdravila Aclasta (glejte poglavje 4.2).
English: Uncommon Decreased appetite Rare
Slovenian: občasni zmanjšan apetit redki hipofosfatemija
English: Rare cases of renal failure requiring dialysis and rare cases with a fatal outcome have been reported in patients with pre-existing renal dysfunction or other risk factors such as advanced age, concomitant nephrotoxic medicinal products, concomitant diuretic therapy, or dehydration in the post infusion period (see sections 4.4 and 4.8 Class effects)
Slovenian: Bolezni sečil občasni zvišana koncentracija kreatinina v krvi, polakisurija, proteinurija neznana** okvara ledvic; pri bolnikih s predhodno ledvično disfunkcijo ali z drugimi dejavniki tveganja, kot so višja starost bolnika, sočasna uporaba nefrotoksičnih zdravil, diuretičnega zdravljenja ali dehidracija v času po infuziji, so poročali o redkih primerih odpovedi ledvic, pri kateri je potrebna dializa, in redkih primerih s smrtnim izidom (glejte poglavji 4.4 in 4.8 odstavek Učinki po skupinah)
English: Aclasta (N=3,875) event rate
Slovenian: Aclasta (N=3.875) delež dogodkov placebo (N=3.861) delež dogodkov absolutno znižanje deleža zlomov % (IZ)
English: The start of treatment or of a new course of treatment should be delayed in patients with unhealed open soft tissue lesions in the mouth.
Slovenian: Pri bolnikih z nezaceljenimi odprtimi poškodbami mehkih tkiv v ustih je treba začetek zdravljenja oziroma ponovno aplikacijo zdravila odložiti.
English: Severe and occasionally incapacitating bone, joint and/or muscle pain have been infrequently reported in patients taking bisphosphonates, including zoledronic acid (see section 4.8).
Slovenian: Pri bolnikih, ki jemljejo difosfonate, vključno z zoledronsko kislino, so redko poročali o hudih bolečinah v kosteh, sklepih in/ali mišicah, ki so bolnike občasno onesposobile (glejte poglavje 4.8).
English: The increases in BMD were significantly greater in the Aclasta-treated group at the lumbar spine and femoral neck at 12 months compared to risedronate (all p<0.03).
Slovenian: Učinek na mineralno gostoto kosti (bone mineral density - BMD) Po 12 mesecih je bilo povečanje mineralne gostote kosti ledvene hrbtenice in vratu stegnenice statistično značilno večje v skupini bolnikov, ki so prejemali zdravilo Aclasta, v primerjavi s tistimi, ki so prejemali risedronat (vse vrednosti p < 0,03).
English: Talk to your doctor before you are given Aclasta: - if you are being treated with any medicine containing zoledronic acid, which is also the active substance of Aclasta (zoledronic acid is used in adult patients with certain types of cancer to prevent bone complications or to reduce the amount of calcium).
Slovenian: Preden dobite zdravilo Aclasta se posvetujte z zdravnikom: - če se zdravite s katerim od zdravil, ki vsebuje zoledronsko kislino, ki je zdravilna učinkovina tudi v zdravilu Aclasta (zoledronsko kislino uporabljamo za preprečevanje zapletov na kosteh ali za zmanjševanje količine kalcija pri odraslih bolnikih, ki imajo določene vrste raka), - če imate ali ste kdaj prej imeli težave z ledvicami, - če ne morete vsak dan jemati nadomestkov kalcija, - če so vam deloma ali v celoti kirurško odstranili žleze obščitnice, - če so vam odstranili dele črevesa.
English: Treatment with a 5 mg annual dose of Aclasta significantly reduced BSAP by 30% relative to baseline at 12 months which was sustained at 28% below baseline levels at 36 months.
Slovenian: Zdravljenje z odmerkom zdravila Aclasta 5 mg na leto je statistično značilno znižalo koncentracijo kostno specifične alkalne fosfataze po 12 mesecih za 30 % glede na izhodišče.
English: Adequate calcium and vitamin D intake are recommended in association with Aclasta administration.
Slovenian: Skupaj z dajanjem zdravila Aclasta se priporoča zadostno uživanje kalcija in vitamina D.
English: Relative reduction in fracture incidence %
Slovenian: relativno znižanje tveganja za zlome
English: • in adult men at increased risk of fracture, including those with a recent low-trauma hip fracture.
Slovenian: Zdravljenje osteoporoze - pri postmenopavzalnih ženskah, - pri odraslih moških, s povečanim tveganjem za zlome, vključno s tistimi z nedavnim zlomom kolka po lažji poškodbi.
English: Cases of ONJ have been reported in the post-marketing setting for Aclasta.
Slovenian: O osteonekrozi čeljusti so poročali tudi v okviru uporabe v času trženja zdravila Aclasta.
English: A side effect called osteonecrosis of the jaw (ONJ) (bone damage in the jaw) has been reported in the post-marketing setting in patients receiving Aclasta (zoledronic acid) for osteoporosis.
Slovenian: Pri bolnikih, ki so zaradi osteoporoze prejemali zdravilo Aclasta (zoledronsko kislino) v času trženja zdravila, so poročali o neželenem učinku, ki ga imenujemo osteonekroza čeljusti (odmiranje kosti v čeljusti).
English: Unusual fracture of the thigh bone particularly in patients on long-term treatment for osteoporosis may occur rarely.
Slovenian: Redki (pojavijo se lahko pri največ 1 od 1.000 bolnikov) Redko se lahko pojavijo neobičajni zlomi stegnenice, še posebno pri bolnikih, ki so na dolgotrajnem zdravljenju osteoporoze.
English: Uncommon Lethargy, paraesthesia, somnolence, tremor, syncope, dysgeusia
Slovenian: Bolezni živčevja pogosti glavobol, omotičnost občasni letargija, parestezija, somnolenca, tremor, sinkopa, motnje okušanja
English: Multipack
Slovenian: skupno pakiranje
English: Vitamin D levels were not routinely measured but a loading dose of vitamin D (50,000 to 125,000 IU orally or by intramuscular route) was given to the majority of patients 2 weeks prior to infusion.
Slovenian: Zdravilo Aclasta so prejemali enkrat na leto, dokler ni vsaj pri 211 bolnikih v študiji prišlo do dokazanega kliničnega zloma. Koncentracij vitamina D niso merili rutinsko, vendar je večina bolnikov 2 tedna pred infuzijo prejela večji začetni odmerek vitamina D (50.000 do 125.000 i.e. peroralno ali intramuskularno).
English: 1 bottle contains 5 mg zoledronic acid (as monohydrate).
Slovenian: 1 steklenica vsebuje 5 mg zoledronske kisline (v obliki monohidrata).
English: Each bottle with 100 ml of solution contains 5 mg zoledronic acid (as monohydrate).
Slovenian: Vsaka steklenica s 100 ml raztopine vsebuje 5 mg zoledronske kisline (v obliki monohidrata).
English: Atrial fibrillation Uncommon Palpitations
Slovenian: Srčne bolezni pogosti atrijska fibrilacija občasni palpitacije
English: Aclasta
Slovenian: Dojenje
English: In the pooled results, a similar decrease in pain severity and pain interference scores relative to baseline were observed over 6 months for Aclasta and risedronate.
Slovenian: V združenih rezultatih so po 6 mesecih za zdravilo Aclasta in risedronat ugotovili podobno zmanjšanje rezultatov ugotavljanja intenzivnosti bolečine in njenega oviranja vsakdanjih aktivnosti glede na izhodišče.
English: Each bottle of 100 ml contains 5 mg zoledronic acid (as monohydrate).
Slovenian: Ena steklenica s 100 ml vsebuje 5 mg zoledronske kisline (v obliki monohidrata).
English: Renal impairment has been observed following the administration of zoledronic acid, especially in patients with pre-existing renal dysfunction or additional risk factors (e.g advanced age, oncology patients with chemotherapy, concomitant nephrotoxic medicinal products, concomitant diuretic therapy, severe dehydration), with the majority of them receiving a 4 mg dose every 3-4 weeks, but it has been observed in patients after a single administration.
Slovenian: Po uporabi zoledronske kisline so opazili okvaro ledvic, posebno pri bolnikih s predhodno ledvično disfunkcijo ali z dodatnimi dejavniki tveganja (npr. višja starost bolnika, onkološki bolniki s kemoterapijo, spremljajoča nefrotoksična zdravila, spremljajoče diuretično zdravljenje, huda dehidracija).
English: C-reactive protein increased Uncommon Blood calcium decreased Observed in patients taking concomitant glucocorticosteroids.
Slovenian: Preiskave pogosti zvišana koncentracija C-reaktivnega proteina občasni znižana koncentracija kalcija v krvi pri bolnikih, ki so sočasno jemali glukokortikoide * pogosti samo pri Pagetovi bolezni ** na podlagi postmarketinških poročil; pogostnosti ni mogoče oceniti iz razpoložljivih podatkov.
English: Nausea, vomiting, diarrhoea Uncommon Dyspepsia, abdominal pain upper, abdominal pain, gastro-oesophageal reflux disease, constipation, dry mouth, oesophagitis, toothache, gastritis Skin and subcutaneous tissue disorders Uncommon Rash, hyperhidrosis, pruritus, erythema Musculoskeletal and connective tissue disorders
Slovenian: Bolezni prebavil pogosti navzea, bruhanje, driska občasni dispepsija, bolečine v zgornjem delu trebuha, bolečine v trebuhu, gastroezofagealna refluksna bolezen, obstipacija, suha usta, vnetje požiralnika, zobobol, gastritis
English: Aclasta may work for longer than one year, and your doctor will let you know if you need to be treated again.
Slovenian: Zdravnik vam bo povedal, ali potrebujete ponovno zdravljenje.
English: What Aclasta looks like and contents of the pack Aclasta is a clear and colourless solution.
Slovenian: Zdravilo Aclasta je bistra brezbarvna raztopina.
English: Tell your doctor and dentist immediately if you experience such symptoms while being treated with Aclasta or after stopping treatment.
Slovenian: Če pride do navedenih simptomov v času zdravljenja ali po zaključku zdravljenja z zdravilom Aclasta, takoj obvestite svojega zdravnika in zobozdravnika.
English: Atypical subtrochanteric and diaphyseal femoral fractures† (bisphosphonate class adverse reaction)
Slovenian: Infekcijske in parazitske bolezni občasni gripa, nazofaringitis
English: Uncommon Neck pain, musculoskeletal stiffness, joint swelling, muscle spasms, musculoskeletal chest pain, musculoskeletal pain, joint stiffness, arthritis, muscular weakness
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti mialgija, artralgija, bolečine v kosteh, bolečine v hrbtu, bolečine v okončinah občasni bolečina v vratu, mišičnoskeletna okorelost, otekanje sklepov, mišični spazmi, mišičnoskeletna bolečina v prsnem košu, mišičnoskeletna bolečina, okorelost sklepov, artritis, šibkost mišic redki atipični subtrohanterni zlomi stegnenice in zlomi diafize stegnenice† (za difosfonate značilen neželeni učinek)
English: Nervous system disorders
Slovenian: raztopina za infundiranje
English: Vascular disorders
Slovenian: Raztopina za infundiranje
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING
Slovenian: Izgled zdravila Aclasta in vsebina pakiranja
English: Irregular heart rhythm (atrial fibrillation) has been seen in patients receiving Aclasta for the treatment of postmenopausal osteoporosis.
Slovenian: Pogosti (pojavijo se lahko pri največ 1 od 10 bolnikov) Pri bolnicah, ki so prejemale zdravilo Aclasta zaradi postmenopavzalne osteoporoze, so poročali o nepravilnem bitja srca (atrijski fibrilaciji).
English: All participants received 1,000 to 1,500 mg of elemental calcium plus 800 to 1,200 IU of vitamin D supplementation per day.
Slovenian: Vsi preiskovanci so prejemali dodatke 1.000 do 1.500 mg elementarnega kalcija in 800 do 1.200 i.e. vitamina D na dan. Petindevetdeset odstotkov bolnikov je prejelo infuzijo dva ali več tednov po oskrbi zloma kolka, pri tem je bil mediani čas odmerjanja infuzije približno šest tednov po oskrbi zloma kolka.
English: Oral use blister (UPVC/ Monochlorotrifluor ethylene)
Slovenian: 0,45 mg/ 20 mg tableta s prirejenim sproščanjem peroralna uporaba pretisni omot (UPVC/ monoklorotrifluoro etilen)
English: Modified-release tablet
Slovenian: Pot uporabe Stična ovojnina Velikost pakiranja
English: Long-term carcinogenicity studies have not been performed.
Slovenian: Dolgoročnih študij kancerogenosti niso izvedli.
English: The mechanism leading to this risk is unknown.
Slovenian: Mehanizem, ki privede do tega tveganja, ni znan.
English: For further information please see section 2.
Slovenian: Za več informacij glejte poglavje 2.
English: • If you are a young adult.
Slovenian: • če ste mlada odrasla oseba.
English: This appears to be associated with the antidepressant activity.
Slovenian: Zdi se, da je to povezano z antidepresivnim delovanjem.
English: The product information may be subsequently updated by the Member State competent authorities, in liaison with the reference Member State, as appropriate, in accordance with the procedures laid down in Chapter 4 of Title III of Directive 2001/83/EC.
Slovenian: Pristojni organi držav članic lahko v nadaljevanju posodobijo informacije o zdravilu v povezavi z referenčno državo članico, kot je ustrezno, v skladu s postopki iz poglavja 4 naslova III Direktive 2001/83/ES
English: In such cases, it is important to contact your doctor who probably will change your medication.
Slovenian: V takih primerih je pomembno, da se posvetujete z zdravnikom, ki bo verjetno spremenil vaše zdravljenje.
English: The underlying illness may persist for a long time.
Slovenian: Osnovna bolezen lahko vztraja dolgo časa.
English: The maintenance dose is the lowest effective dose.
Slovenian: Vzdrževalni odmerek je najmanjši učinkoviti odmerek.
English: Patients who display signs of toxicity should be monitored for a minimum of 12 hours.
Slovenian: Bolnike, ki kažejo znake toksičnosti, je treba spremljati vsaj 12 ur.
English: Consider a 50% reduction of the recommended starting dose.
Slovenian: Razmisliti je treba o 50-odstotnem zmanjšanju priporočenega začetnega odmerka.
English: Do not chew them.
Slovenian: Ne žvečite jih.
English: Although these investigations revealed partially contradictory results, particularly a potential to induce chromosome aberrations cannot be excluded.
Slovenian: Čeprav so te študije razkrile delno nasprotujoče izsledke, predvsem možnih kromosomskih aberacij ni mogoče izključiti.
English: The systemic bioavailability is about 50% of the intravenous injection.>
Slovenian: Sistemska biološka uporabnost je približno 50 % intravenske injekcije.>
English: Patients with special risks
Slovenian: Bolniki s posebnimi dejavniki tveganja
English: Contact your doctor immediately.
Slovenian: Takoj se posvetujte z zdravnikom.
English: Treatment in respirator is advised to prevent a possible respiratory arrest.
Slovenian: Zdravljenje v respiratorju se priporoča za preprečevanje možnega zastoja dihanja.
English: It may be necessary to adjust the dosage of these drugs.
Slovenian: Morda bo treba prilagoditi odmerek teh zdravil.
English: infusion and i.m.
Slovenian: infundiranje in i.m.
English: It is general clinical experience that the risk of suicide may increase in the early stages of recovery.
Slovenian: Splošne klinične izkušnje kažejo, da se tveganje za samomor v zgodnji fazi okrevanja lahko poveča.
English: • are taking any other medication that may cause heart problems, or
Slovenian: • jemljete druga zdravila, ki lahko povzročijo težave s srcem, ali
English: As with other medicines for the treatment of depression it may take a few weeks before you feel any improvement.
Slovenian: Kot pri drugih zdravilih za zdravljenje depresije lahko traja nekaj tednov, preden boste občutili izboljšanje.
English: If you forget to take X Take the next dose at the usual time.
Slovenian: Če ste pozabili vzeti zdravilo X Naslednji odmerek vzemite ob običajnem času.
English: This medicine should not be used for children below 6 years of age.
Slovenian: Tega zdravila se ne sme uporabljati pri otrocih, mlajših od 6 let.
English: In children under 6 years of age.
Slovenian: Otroci, mlajši od 6 let.
English: Generally, the lowest effective dose should be used for the shortest duration required to treat the symptoms.
Slovenian: Na splošno je treba uporabiti najmanjši učinkovit odmerek in to najkrajši čas, potreben za zdravljenje simptomov.
English: Do this even if there are no signs of discomfort or poisoning.
Slovenian: To storite, tudi če nimate znakov nelagodja ali zastrupitve.
English: Talk with your physician in case you have the impression that the effect of X is too strong or weak.
Slovenian: Posvetujte se z zdravnikom, če imate občutek, da je učinek zdravila X premočan ali prešibek.
English: • increased production of breast milk or breast milk outflow without breast feeding
Slovenian: • povečano nastajanje materinega mleka ali iztekanje materinega mleka brez dojenja
English: Symptoms of overdose include:
Slovenian: Simptomi prevelikega odmerjanja vključujejo:
English: Your doctor will re-evaluate your treatment after 3 months and if needed perform a new ECG.
Slovenian: Zdravnik bo vaše zdravljenje ponovno ocenil po 3 mesecih in po potrebi ponovno naredil EKG.
English: The reason for the effect on fertility is unknown.
Slovenian: Vzrok učinka na plodnost ni znan.
English: In many patients, therapy may be needed for several years.
Slovenian: Mnoge bolnike bo morda treba zdraviti več let.
English: The plasma protein binding is about 95%.
Slovenian: Vezava na beljakovine v plazmi je približno 95 %.
English: This leaflet was last revised in <{MM/YYYY}> <{month YYYY}>.
Slovenian: Navodilo je bilo nazadnje revidirano <{MM/LLLL}> <{mesec LLLL}>.
English: Admission to hospital (intensive care unit) if required.
Slovenian: Hospitalizacija (enota intenzivne nege), če je potrebna.
English: It is generally recommended to initiate treatment in the lower dose range as recommended for adult.
Slovenian: Na splošno se priporoča, da se zdravljenje začne z nižjim odmerkom, kot je priporočeno za odrasle.
English: • elevation or lowering of blood sugar levels
Slovenian: • zvišanje ali znižanje ravni krvnega sladkorja
English: The dose should be increased gradually.
Slovenian: Odmerek je treba povečevati postopno.
English: Monitor for rhabdomyolysis if the patient has been unconscious for a considerable time.
Slovenian: Spremljanje rabdomiolize, če je bil bolnik dlje časa nezavesten.
English: Since overdosage is often deliberate, patients may attempt suicide by other means during the recovery phase.
Slovenian: Ker je preveliko odmerjanje pogosto namerno, lahko bolniki v času okrevanja poskušajo narediti samomor na kakšen drug način.
English: This risk persists until significant remission occurs.
Slovenian: Takšno tveganje obstaja, vse dokler ne pride do znatnega izboljšanja zdravstvenega stanja.
English: If you stop your treatment too soon, your symptoms may return.
Slovenian: Če z zdravljenjem prehitro prenehate, se lahko simptomi ponovijo.
English: As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs.
Slovenian: Ker se zdravstveno stanje morda še ne bo izboljšalo v prvih ali več tednih zdravljenja, je treba bolnike skrbno nadzirati, dokler ne pride do izboljšanja.
English: Use in children and adolescents X should not be given to children or adolescents.
Slovenian: Uporaba pri otrocih in mladostnikih Zdravila X se ne sme dajati otrokom ali mladostnikom.
English: This medicine can be taken with or without food.
Slovenian: To zdravilo se lahko jemlje s hrano ali brez nje.
English: • excitement, anxiety, difficulties sleeping, nightmares
Slovenian: • vznemirjenost, tesnoba, težave s spanjem, nočne more
English: The renal elimination of unchanged amitriptyline is insignificant (about 2%).
Slovenian: Izločanje nespremenjenega amitriptilina preko ledvic je nepomembno (približno 2 %).
English: injection).
Slovenian: injekcija).
English: You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour.
Slovenian: Prosite ga, da vas opozori, če meni, da sta se depresija ali anksioznost pri vas poslabšali, ali če ga skrbijo spremembe v vašem vedenju.
English: This medicine may cause drowsiness and dizziness, especially in the beginning of the treatment.
Slovenian: To zdravilo lahko povzroči zaspanost in omotico, predvsem na začetku zdravljenja.
English: This is characterized by profuse and rapidly changing ideas, exaggerated gaiety and excessive physical activity.
Slovenian: Zanjo so značilne prehitevajoče misli, ki se hitro spreminjajo, pretirano veselje in pretirana telesna aktivnost.
English: Perform electrocardiograph-look for QRS>0.16 seconds 4.
Slovenian: EKG - posebna pozornost na QRS > 0,16 sekunde.
English: Some medicines may affect the action of other medicines and this can sometimes cause serious side effects.
Slovenian: Nekatera zdravila lahko vplivajo na delovanje drugih zdravil, kar lahko včasih povzroči resne neželene učinke.
English: • dry mouth and tongue
Slovenian: • suha usta in jezik
English: Tell your doctor if you have, or have had in the past, any medical problems, especially if you have
Slovenian: Povejte zdravniku, če imate ali ste imeli kakršne koli zdravstvene težave, predvsem če imate
English: Long-term safety data in children and adolescents concerning growth, maturation and cognitive and behavioural development are not available (see section 4.2).
Slovenian: Podatkov o varnosti zdravila po dolgotrajnem zdravljenju pri otrocih in mladostnikih v zvezi z rastjo, dozorevanjem in kognitivnim ter vedenjskim razvojem ni na voljo (glejte poglavje 4.2).
English: Close monitoring even in apparently uncomplicated cases.
Slovenian: Skrbno spremljanje, tudi če je primer na videz nezapleten.
English: The elimination half-life from plasma after i.v.
Slovenian: Razpolovni čas izločanja iz plazme po i.v.
English: If you have difficulty in swallowing the capsules, you can open them and put the pellets in e.g. yoghurt or a cold drink.
Slovenian: Če imate težave s požiranjem kapsul, jih odprite in zrnca vsipajte v npr. jogurt ali hladno pijačo.
English: If you get any of the following symptoms you should see your doctor immediately:
Slovenian: Če opazite katerega od naslednjih simptomov, se takoj posvetujte z zdravnikom:
English: • sexual disturbances (decreased sex-drive, problems with erection)
Slovenian: • motnje spolnosti (zmanjšana spolna sla, težave z erekcijo)
English: Preferred Term
Slovenian: Prednostni izraz
English: This medicine should not be given to children or adolescents for treatment of depression.
Slovenian: Tega zdravila se ne sme dajati otrokom ali mladostnikom za zdravljenje depresije.
English: You may be more likely to think like this:
Slovenian: Pojav takih misli je verjetnejši:
English: If a dose increase is required this should be done stepwise within 3 to 7 days.
Slovenian: Če je treba odmerek povečati, naj bo to postopno v obdobju 3 do 7 dni.
English: Suicide/suicidal thoughts
Slovenian: Samomor/samomorilne misli
English: The maximum plasma concentration is reached only after 1 to 5 (-8) hours.
Slovenian: Največja koncentracija v plazmi je dosežena šele po 1 do 5 (-8) urah.