FrancophonIA/ELRC3.0 huggingface dataset:
English: PCTFE/PVC/Al-blister containing 14 film-coated tablets.
Croatian: PCTFE/ PVC/Al blister koji sadrži 14 filmom obloženih tableta.
English: The tablets are packed in PCTFE/PVC/Al-blisters.
Croatian: Tablete su pakirane u blisterima od PCTFE/PVC/Al.
English: If you have taken more Truberzi than you should, tell your doctor or seek urgent medical assistance.
Croatian: Ako ste uzeli više lijeka Truberzi nego što ste trebali, obavijestite svog liječnika ili potražite hitnu medicinsku pomoć.
English: Patients should be instructed if they miss a dose (delay of 4 hours) to take the next dose at the regular time and not to take 2 doses at the same time to make up for a missed dose.
Croatian: Bolesnike treba uputiti da ako propuste dozu lijeka (odgoda od 4 sata) uzmu sljedeću dozu u predviđeno vrijeme i da ne smiju uzeti dvije doze odjednom kako bi nadoknadili propuštenu dozu.
English: Truberzi should not be taken whilst pregnant or breast-feeding.
Croatian: Truberzi se ne smije uzimati tijekom trudnoće ili dojenja.
English: Composite Response
Croatian: Kompozitni odgovor
English: Warner Chilcott Deutschland GmbH Dr.-Otto-Roehm-Strasse 2-4, 64331 Weiterstadt, Germany
Croatian: Warner Chilcott Deutschland GmbH Dr.-Otto-Roehm-Strasse 2-4, 64331 Weiterstadt,
English: In the event of acute overdose, the patient should be carefully observed and given standard supportive treatment as required.
Croatian: U slučaju akutnog predoziranja bolesnika treba pažljivo promatrati i po potrebi mu pružiti standardno potporno liječenje.
English: on a 1 to 7 scale over the week prior to randomization.
Croatian: ≥5 na ljestvici od 1 do 7 tijekom tjedna prije randomizacije.
English: If you take more Truberzi than you should
Croatian: Ako uzmete više lijeka Truberzi nego što ste trebali
English: Medicinal products that cause constipation
Croatian: Lijekovi koji uzrokuju konstipaciju
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Truberzi therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je odlučiti da li prekinuti dojenje ili prekinuti liječenje/suzdržati se od liječenja lijekom Truberzi uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: • pain may begin soon after you start Truberzi.
Croatian: • bol može nastupiti ubrzo nakon što počnete uzimati Truberzi.
English: All events resolved upon discontinuation of Truberzi, with symptoms typically improved by the following day.
Croatian: Svi su se događaji povukli nakon prekida primjene lijeka Truberzi, a simptomi su se obično poboljšali do sljedećeg dana.
English: As a precautionary measure, it is preferable to avoid the use of Truberzi during pregnancy.
Croatian: Kao mjeru opreza, preporučuje se izbjegavati primjenu lijeka Truberzi tijekom trudnoće.
English: However, such an increase is unlikely to be of clinical significance (see section 5.2).
Croatian: Međutim, nije vjerojatno da je takvo povećanje klinički značajno (vidjeti dio 5.2).
English: Overall, patients had a mean age of 45 years (range 18-80 years with 10% at least 65 years of age or older), 66% female, 86% white, 12% black, and 27% Hispanic.
Croatian: Sveukupno, srednja vrijednost dobi bolesnika bila je 45 godina (raspon 18-80 godina sa 10% u dobi od najmanje 65 ili više godina), 66% žena, 86% bijelaca, 12% crnaca i 27% Hispanaca.
English: The absolute bioavailability of eluxadoline has not been determined but is estimated to be low due to limited absorption and first pass effects.
Croatian: Apsolutna bioraspoloživost eluksadolina nije utvrđena, ali se procjenjuje da je niska zbog ograničene apsorpcije i učinaka prvog prolaska.
English: What Truberzi looks like and contents of the pack
Croatian: Kako Truberzi izgleda i sadržaj pakiranja
English: Your doctor may prescribe you a lower dose of one 75 mg tablet twice a day if you: - are 65 years of age or older; - are unable to tolerate the 100 mg dose;
Croatian: Vaš liječnik može propisati nižu dozu od jedne tablete od 75 mg dvaput na dan ako: - imate 65 godina ili više; - ne podnosite dozu od 100 mg;
English: The effect on other statins which are more sensitive OATP1B1 substrates (e.g. simvastatin and atorvastatin), however, may be more pronounced.
Croatian: Učinak na druge statine koji su osjetljiviji supstrati OATP1B1 (npr. simvastatin i atorvastatin), međutim, može biti izraženiji.
English: The safety and efficacy of eluxadoline in this subgroup of IBS-D patients has not been established.
Croatian: Sigurnost i djelotvornost eluksadolina u toj podskupini IBS-D bolesnika nisu ustanovljene.
English: Based on the physical-chemical and biopharmaceutical properties (very low oral bioavailability), eluxadoline is expected to have minimal abuse or dependence liability.
Croatian: Na temelju fizikalno-kemijskih i biofarmaceutskih svojstava (vrlo niska bioraspoloživost nakon peroralne primjene), očekuje se da će eluksadolin imati minimalan utjecaj na zlouporabu ili ovisnost.
English: 4 “Gastrooesophageal reflux disease” term includes gastrooesophageal reflux disease, dyspepsia and gastritis.
Croatian: 4 Pojam „gastroezofagealna refluksna bolest“ obuhvaća gastroezofagealnu refluksnu bolest, dispepsiju i gastritis.
English: Mean plasma elimination half-life is 5 hours with high inter-subject variability.
Croatian: Srednja vrijednost poluvijeka eliminacije iz plazme je 5 sati, uz visoku varijabilnost između ispitanika.
English: The active substance has linear pharmacokinetics with no accumulation upon repeated twice daily dosing.
Croatian: Djelatna tvar ima linearnu farmakokinetiku bez nakupljanja pri ponovljenom doziranju dvaput na dan.
English: All pancreatic events, whether or not associated with sphincter of Oddi spasm, were retrospectively evaluated as mild, indicating an absence of organ failure and local or systemic complications.
Croatian: Svi događaji povezani s gušteračom, bilo da su povezani sa spazmom Oddijevog sfinktera ili ne, bili su retrospektivno procijenjeni kao blagi, što ukazuje na odsustvo zatajenja organa i lokalnih ili sistemskih komplikacija.
English: The administration of eluxadoline with a high fat meal significantly decreased both Cmax (50%) and AUC (60%) without any effect on Tmax.
Croatian: Primjena eluksadolina s obrokom s visokim udjelom masti značajno je smanjila i Cmax (50%) i AUC (60%) bez učinaka na Tmax.
English: Upon administration of multiple oral doses twice daily, there was no accumulation of active substance.
Croatian: Kod primjene višestrukih oralnih doza dvaput na dan nije bilo nakupljanja djelatne tvari.
English: Therefore, the 75 mg dose twice daily can be considered for this population, but its benefit risk ratio should be periodically assessed in the context of their symptoms severity (see section 4.2).
Croatian: Stoga se doza od 75 mg dva puta na dan može uzeti u obzir u toj populaciji, ali je potrebno povremeno procijeniti omjer koristi i rizika u kontekstu težine njihovih simptoma (vidjeti dio 4.2).
English: All patients should be instructed not to use alcohol while on treatment with eluxadoline.
Croatian: Sve bolesnike treba uputiti da izbjegavaju konzumiranje alkohola tijekom liječenja eluksadolinom.
English: There was an overall increased frequency of adverse events in the older population compared to patients <65 years which was comparable across all treatment groups, including placebo.
Croatian: Došlo je do sveukupnog porasta u učestalosti štetnih događaja u starijoj populaciji u usporedbi s bolesnicima u dobi od <65 godina, što je bilo usporedivo u svim liječenim skupinama, uključujući i skupinu s placebom.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of eluxadoline in milk (for details see section 5.3).
Croatian: Dostupni farmakodinamički/toksikološki podaci u životinja pokazuju da se eluksadolin izlučuje u mlijeko (za detalje vidjeti dio 5.3).
English: Serious cases resulting in hospitalization and death, primarily in patients without a gallbladder have been reported.
Croatian: Prijavljeni su ozbiljni slučajevi koji su završili hospitalizacijom i smrću, prvenstveno u bolesnika bez žučnog mjehura.
English: Other substrates potentially affected include e.g. sartans (valsartan, olmesaran).
Croatian: Drugi supstrati koji mogu biti zahvaćeni uključuju npr. sartane (valsartan, olmesartan).
English: Other side effects can include
Croatian: Druge nuspojave mogu uključivati
English: 80% (8/10) of sphincter of Oddi spasm events presented within the first week of treatment.
Croatian: (8/10) događaja spazma Oddijevog sfinktera javilo se unutar prvog tjedna liječenja.
English: Since bioavailability is limited, the pharmacodynamic activity of eluxadoline is based predominantly on local action within the GI tract.
Croatian: Budući da je bioraspoloživost ograničena, farmakodinamička aktivnost eluksadolina temelji se pretežno na lokalnom djelovanju unutar GI trakta.
English: However, you may experience side effects such as sleepiness or dizziness while taking Truberzi which might affect your ability to drive or use machines.
Croatian: Međutim, postoji mogućnost da se pojave nuspojave poput pospanosti ili omaglice dok uzimate Truberzi, što može utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Treatment with eluxadoline also resulted in significant improvements in patients whose IBS-D symptoms were not adequately controlled with use of loperamide prior to enrolment.
Croatian: Liječenje eluksadolinom također je rezultiralo značajnim poboljšanjem u bolesnika čiji simptomi IBS-D-a nisu bili odgovarajuće kontrolirani primjenom loperamida prije uključivanja.
English: An overdose of eluxadoline may result in symptoms resulting from an exaggeration of the known pharmacodynamic effects of the medicinal product.
Croatian: Predoziranje eluksadolinom može rezultirati simptomima koji su posljedica pretjeranih poznatih farmakodinamičkih učinaka lijeka.
English: As patient's genetic disposition may be unknown, it is recommended that patients be monitored for impaired mental or physical abilities needed to perform potentially hazardous activities such as driving a car or using machines (see sections 4.7. and 4.8).
Croatian: Budući da bolesnikova genetska dispozicija može biti nepoznata, preporučuje se nadziranje bolesnika kako bi se uočile smanjene mentalne ili fizičke sposobnosti potrebne za obavljanje potencijalno opasnih aktivnosti kao što su upravljanje vozilima ili rad sa strojevima (vidjeti dijelove 4.7 i 4.8).
English: The binding affinities (Ki) of eluxadoline for human μOR and δOR are 1.8 nM and 430 nM, respectively.
Croatian: Afiniteti vezivanja (Ki) eluksadolina za ljudski μOR i δOR su 1,8 nM, odnosno 430 nM.
English: Although no direct drug-drug interactions have been demonstrated, chronic use of loperamide with eluxadoline should be avoided as this may increase the risk of constipation.
Croatian: Iako nisu dokazane izravne interakcije s drugim lijekovima, treba izbjegavati kroničnu primjenu loperamida s eluksadolinom jer to može povećati rizik od konstipacije.
English: Increased ALT Increased AST 1“Somnolence” term includes: somnolence and sedation.
Croatian: 1 Pojam „somnolencija”obuhvaća: somnolenciju i sedaciju.
English: However, caution should be exercised in patients receiving high doses of OATP1B1 substrates (see section 4.5).
Croatian: Međutim, potreban je oprez u bolesnika koji primaju visoke doze supstrata OATP1B1 (vidjeti dio 4.5).
English: • Hepatic impairment (Child-Pugh Class A-C).
Croatian: • Oštećenje funkcije jetre (Child-Pugh stadij A-C).
English: Truberzi is contraindicated in patients without a gallbladder.
Croatian: Truberzi je kontraindiciran u bolesnika bez žučnog mjehura.
English: These patients may be at risk for severe complications of bowel obstruction.
Croatian: U tih bolesnika može postojati rizik od teških komplikacija opstrukcije crijeva.
English: The absorption of eluxadoline was rapid under fasting conditions, with a median Tmax value of 2 hours.
Croatian: Apsorpcija eluksadolina bila je brza natašte, s medijanom Tmax vrijednosti od 2 sata.
English: Please report to your doctor: - how much alcohol you drink (e.g. daily number of drinks); - if you experience any effects, such as dizziness and sleepiness.
Croatian: - koliko alkohola konzumirate (npr. broj pića dnevno); - ako imate bilo kakve posljedice, kao što su omaglica i pospanost.
English: Overall, there was an increased frequency of adverse events reported for patients aged 65 years or greater in the clinical studies.
Croatian: Sveukupno, prijavljena je povećana učestalost štetnih događaja kod bolesnika u dobi od 65 ili više godina u kliničkim ispitivanjima.
English: Taken together these results suggest that when using the medicinal product as directed at therapeutic doses patients will not experience significant central nervous system effects or adverse events consistent with a drug of abuse.
Croatian: Uzeti zajedno, rezultati ukazuju na to da kada se lijek primjenjuje u skladu s uputama u terapijskim dozama bolesnici neće imati značajne učinke na središnjem živčanom sustavu ili štetne događaje koji odgovaraju onima zlouporabe lijeka.
English: In patients with IBS-D, no signal for central nervous system-mediated adverse events was identified.
Croatian: U bolesnika s dijagnozom IBS-D-a, nije utvrđen signal za štetne događaje posredovane središnjim živčanim sustavom.
English: Eluxadoline exists predominantly as the (S,S)-diastereomer (>99%) and undergoes little or no chiral conversion in vivo.
Croatian: Eluksadolin postoji pretežno kao (S,S)-dijastereomer (>99%), a kiralna konverzija in vivo je minimalna ili odsutna.
English: These medicines can include: - erythromycin (used to treat infections);
Croatian: Ti lijekovi mogu uključivati: - eritromicin (koristi se za liječenje infekcija);
English: If you stop taking Truberzi
Croatian: Ako prestanete uzimati Truberzi
English: Study1 (IBS-3001) continued double-blinded for an additional 26 weeks for long-term safety (total of 52 weeks of treatment), followed by a 2-week follow-up.
Croatian: Ispitivanje 1 (IBS-3001) nastavilo se kao dvostruko slijepo dodatnih 26 tjedana radi dugoročne sigurnosti (ukupno 52 tjedna liječenja), nakon čega je uslijedilo dvotjedno praćenje.
English: What you need to know before you take Truberzi 3.
Croatian: Što morate znati prije nego počnete uzimati Truberzi
English: Risk of constipation with eluxadoline in patients with other IBS sub-types is unknown, but may be increased.
Croatian: Rizik od konstipacije uz eluksadolin u bolesnika s drugim podvrstama IBS-a nije poznat, ali može biti povišen.
English: • Hypersensitivity to eluxadoline or to any of the excipients listed in section 6.1.
Croatian: • Preosjetljivost na eluksadolin ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: Therefore, eluxadoline is contraindicated in this population as well as in those with previous biliary tract problems (see sections 4.2, 4.3 and 4.4).
Croatian: Stoga je eluksadolin kontraindiciran u toj populaciji kao i u onima s prethodnim problemima sa žučovodom (vidjeti dijelove 4.2, 4.3 i 4.4).
English: If patients develop severe constipation, they should be instructed to stop Truberzi and seek medical attention.
Croatian: Ako se u bolesnika pojavi teška konstipacija, treba ih upozoriti da prekinu liječenje lijekom Truberzi i potraže liječničku pomoć.
English: For the daily composite response, eluxadoline began to separate from placebo shortly after initiating treatment with a maximal effect seen at 4-6 weeks that was maintained throughout the course of treatment.
Croatian: Za dnevni kompozitni odgovor, eluksadolin se počeo odvajati od placeba kratko nakon početka liječenja s maksimalno postignutim učinkom u 4.-6. tjednu koji je održan tijekom cijelog razdoblja liječenja.
English: If any of the above applies to you, tell your doctor or pharmacist before taking Truberzi.
Croatian: Ako se bilo što od navedenog odnosi na Vas, razgovarajte s liječnikom ili ljekarnikom prije uzimanja lijeka Truberzi.
English: The binding affinity (Ki) of eluxadoline for human κOR has not been determined; however, the Ki for guinea pig cerebellum κOR is 55 nM.
Croatian: Afinitet vezivanja (Ki) eluksadolina za ljudski κOR nije utvrđen; međutim, Ki za κOR malog mozga zamorca je 55 nM.
English: Talk to your doctor or pharmacist if you are unsure if any of the above apply to you.
Croatian: Obratite se svom liječniku ili ljekarniku ako niste sigurni odnosi li se išta od navedenog na Vas.
English: Avoid use with other drugs that may cause constipation (see section 4.5).
Croatian: Izbjegavajte upotrebu s drugim lijekovima koji mogu uzrokovati konstipaciju (vidjeti dio 4.5).
English: In rat, eluxadoline was excreted into milk in an approximately dose proportional manner with maximal concentrations less than plasma concentrations.
Croatian: U štakora, eluksadolin se izlučivao u mlijeko u koncentraciji približno proporcionalnoj dozi, a maksimalne koncentracije bile su manje nego koncentracije u plazmi.
English: Pharmacokinetic data for healthy volunteers pooled across Phase 1 studies (using the 100 mg single oral dose) and analyzed for potential differences based on sex, age, race, and BMI demonstrated no significant differences.
Croatian: Farmakokinetički podaci zdravih dobrovoljaca koji su objedinjeni iz svih ispitivanjima faze 1 (primjenom jednokratne oralne doze od 100 mg) i analizirani kako bi se utvrdile moguće razlike na temelju spola, dobi, rase i ITM-a nisu pokazali značajne razlike.
English: No human data on the effect of eluxadoline on fertility are available.
Croatian: Nisu dostupni podaci o učinku eluksadolina na plodnost u ljudi.
English: Eluxadoline should not be used in children and adolescents as it has not been studied in this population (see section 4.2).
Croatian: Eluksadolin se ne smije primjenjivati u djece i adolescenata jer nije ispitan u toj populaciji (vidjeti dio 4.2).
English: All pancreatic events resolved with lipase normalization upon discontinuation of eluxadoline, with 80% (4/5) resolving within 1 week of treatment discontinuation (see section 4.4).
Croatian: Svi događaji povezani s gušteračom riješili su se normalizacijom lipaze nakon prekida primjene eluksadolina, od kojih se 80% (4/5) riješilo unutar 1 tjedna od prekida liječenja (vidjeti dio 4.4).
English: inhibitory concentration [IC50] of approximately 20 µM [11 µg/mL]), although this is not expected to result in any clinically meaningful interactions.
Croatian: CYP2E1 je bio malo inhibiran (50% inhibicijske koncentracije [IC50] od približno 20 µM [11 µg/ml]), iako se ne očekuje da će to rezultirati bilo kakvom klinički značajnom interakcijom.
English: Do not stop taking Truberzi without first talking to your doctor as your symptoms may worsen.
Croatian: Truberzi bez prethodnog razgovora s liječnikom jer bi se Vaši simptomi mogli pogoršati.
English: Of 1,795 IBS-D patients who were enrolled in clinical studies of eluxadoline and assigned to 75 mg or 100 mg twice daily, 139 (7.7%) were at least 65 years of age, while 15 (0.8%) were at least 75 years old.
Croatian: Od 1795 bolesnika s IBS-D-om koji su bili uključeni u klinička ispitivanja eluksadolina i kojima je bila dodijeljena doza od 75 mg ili 100 mg dvaput na dan, 139 (7,7%) bilo je u dobi od najmanje 65 godina, dok je 15 (0,8%) bilo u dobi od najmanje 75 godina.
English: In animals, eluxadoline interacts with opioid receptors in the gut.
Croatian: U životinja, eluksadolin stupa u interakciju s opioidnim receptorima u crijevima.
English: Results for endpoints were based on electronic daily diary entries by patients.
Croatian: Rezultati mjera ishoda temeljili su se na elektroničkim dnevnim zapisima u obliku dnevnika koji su unosili bolesnici.
English: Patients receiving eluxadoline reported significant increases in urgency-free days both for ≥50% urgency-free days as well as ≥75% urgency free days.
Croatian: Bolesnici koji su primali eluksadolin prijavili su značajan porast u danima bez hitnosti kako za ≥50% dana bez hitnosti tako i za ≥75% dana bez hitnosti.
English: Eluxadoline also reverses hyperalgesic responses in an animal model of acute colitis-induced visceral pain.
Croatian: Eluksadolin također poništava hiperalgetičke odgovore u životinjskom modelu akutne visceralne boli inducirane kolitisom.
English: In vitro studies indicate that eluxadoline is neither an inducer of CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4, nor an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2C8 and CYP2D6 at clinically relevant concentrations.
Croatian: In vitro ispitivanja ukazuju da eluksadolin ne djeluje kao induktor CYP1A2, CYP2B6, CYP2C9, CYP2C19 i CYP3A4, niti kao inhibitor CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2C8 i CYP2D6 pri klinički značajnim koncentracijama.
English: Due to events of somnolence and sedation observed in clinical studies, caution should be exercised (see sections 4.4 and 4.5).
Croatian: Zbog događaja somnolencije i sedacije zapaženih u kliničkim ispitivanjima, potreban je oprez (vidjeti dijelove 4.4 i
English: Some medicines may increase the level of Truberzi in the blood.
Croatian: Određeni lijekovi mogu povećati razinu lijeka Truberzi u krvi.
English: A total of 1,282 patients in Study 1 (IBS-3001) and 1,146 patients in Study 2 (IBS-3002) were enrolled and received treatment with Truberzi 75 mg, Truberzi 100 mg or placebo twice daily.
Croatian: Uključeno je ukupno 1282 bolesnika u Ispitivanju 1 (IBS-3001) i 1146 bolesnika u Ispitivanju 2 (IBS-3002), a dobivali su lijek Truberzi 75 mg, Truberzi 100 mg ili placebo dvaput na dan.
English: Eluxadoline has very low oral bioavailability and exerts no detectable central nervous system (CNS)-mediated effects when administered orally to animals at effective doses.
Croatian: Eluksadolin ima vrlo nisku bioraspoloživost nakon peroralne primjene i nema mjerljivih učinaka posredovanih središnjim živčanim sustavom (SŽS) kada se primjenjuje peroralno u životinja u učinkovitim dozama.
English: Avoid taking Truberzi with any other medicines that may cause constipation (see Section 2: Other medicines and Truberzi).
Croatian: Izbjegavajte uzimanje lijeka Truberzi s drugim lijekovima koji mogu uzrokovati zatvor (vidjeti dio 2: Drugi lijekovi i Truberzi).
English: Truberzi is contraindicated in patients without a gallbladder and other conditions that increase the risk of developing pancreatitis (see section 4.3).
Croatian: Truberzi je kontraindiciran u bolesnika bez žučnog mjehura i s drugim stanjima koja povećavaju rizik od razvoja pankreatitisa (vidjeti dio 4.3).
English: • Patients without a gallbladder (e.g. due to cholecystectomy or agenesis).
Croatian: • Bolesnici koji nemaju žučni mjehur (npr. zbog kolecistektomije ili agenezije).
English: The efficacy and safety of eluxadoline in IBS-D patients was established in two randomized, multicenter, multi-national, double-blind, placebo-controlled studies (Studies 1 & 2).
Croatian: Djelotvornost i sigurnost eluksadolina u bolesnika s dijagnozom IBS-D-a ustanovljene su u dva randomizirana, multicentrična, multinacionalna, dvostruko slijepa, placebom-kontrolirana ispitivanja
English: Supporting the lack of systemic pharmacodynamic effects are results from an oral abuse liability study in recreational opioid users that showed oral doses up to 1,000 mg did not produce significant pupillary constriction or significant drug liking.
Croatian: U prilog nedostatku sistemskih farmakodinamičkih učinaka idu rezultati ispitivanja utjecaja na ovisnost o oralnoj primjeni lijeka u rekreacijskih korisnika opioida koji su pokazali da oralne doze do 1000 mg ne izazivaju značajno sužavanje zjenice niti značajan užitak u lijeku.
English: (see sections 4.2 and 4.4).
Croatian: (vidjeti dijelove 4.3 i 4.5).
English: If you forget to take Truberzi
Croatian: Ako ste zaboravili uzeti Truberzi
English: Skin and subcutaneous tissue disorders
Croatian: Poremećaji kože i potkožnog tkiva osip5