FrancophonIA/ELRC3.0 huggingface dataset:
English: In this way Ivabradine JensonR helps to control and reduce the number of angina attacks.
Croatian: Na taj način, Ivabradine JensonR pomaže u kontroliranju i smanjenju broja napadaja angine.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Croatian: Zahtjevi za podnošenje periodičkih izvješća o neškodiljvosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim slijedećim ažuriranim verzijama objavljenima na europskom internetskom portalu za lijekove.
English: Food delayed absorption by approximately 1 hour, and increased plasma exposure by 20 to 30%.
Croatian: Hrana usporava apsorpciju za oko 1 sat, te povećava izloženost u plazmi za 20 do 30 %.
English: If you forget to take a dose of Ivabradine JensonR, take the next dose at the usual time.
Croatian: Ako zaboravite uzeti jednu dozu lijeka Ivabradine JensonR, uzmite sljedeću dozu u uobičajeno vrijeme.
English: If you think that the effect of Ivabradine JensonR is too strong or too weak, talk to your doctor or pharmacist.
Croatian: Ako mislite da je učinak lijeka Ivabradine JensonR prejak ili preslab, razgovarajte s liječnikom ili ljekarnikom.
English: EU/1/16/1145/016 EU/1/16/1145/017
Croatian: EU/1/16/1145/017
English: George Borg Barthet Ltd.
Croatian: George Borg Barthet
English: Very rare (may affect up to 1 in 10,000 people): Irregular heart beats.
Croatian: Vrlo rijetko (mogu se javiti u do 1 na 10 000 osoba): Nepravilni otkucaji srca.
English: In addition, discontinuation of treatment should be considered if there is only limited symptomatic response and when there is no clinically relevant reduction in resting heart rate within three months.
Croatian: Nadalje, prekid liječenja potrebno je razmotriti kada postoji samo ograničeni odgovor s obzirom na simptome i kada ne postoji kliničko značajno smanjenje srčane frekvencije unutar 3 mjeseca liječenja.
English: They generally occur within the first two months of treatment after which they may occur repeatedly and resolve during or after treatment.
Croatian: Obično se javljaju unutar prva dva mjeseca liječenja nakon čega se mogu ponavljano javljati i nestati tijekom ili nakon liječenja.
English: The following adverse reactions have been reported during clinical trials and are ranked using the following frequency: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Croatian: Tijekom kliničkih ispitivanja zabilježene su slijedeće nuspojave, a prema učestalosti razvrstane su na sljedeći način: vrlo često (≥ 1/10); često (≥ 1/100 do < 1/10); manje često (≥ 1/1000 do < 1/100); rijetko (≥ 1/10 000 do < 1/1000); vrlo rijetko (< 1/10 000); nepoznato (ne može se procijeniti iz dostupnih podataka).
English: For bottles, use within 6 months after first opening.
Croatian: Za boce, iskoristiti u roku od 6 mjeseci nakon prvog otvaranja.
English: Under physiological conditions, ivabradine is rapidly released from tablets and is highly water-soluble (>10 mg/ml).
Croatian: U fiziološkim se uvjetima ivabradin brzo oslobađa iz tableta te je vrlo topljiv u vodi (> 10 mg/ml).
English: Treatment effect on the primary composite endpoint, its components and secondary endpoints
Croatian: Učinak liječenja na primarnu kompozitnu mjeru ishoda, njezine pojedine komponente i sekundarne mjere ishoda.
English: Do not use this medicine after the expiry date which is stated on the carton, bottle and blister after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji, boci i blisteru iza „Rok valjanosti” i „EXP”.
English: The calendar printed on the blister containing the tablets should help you remember when you last took a tablet of Ivabradine JensonR.
Croatian: Kalendarski dani otisnuti na blisteru koji sadrži tablete trebali bi Vam pomoći da zapamtite kada ste zadnji put uzeli tabletu lijeka Ivabradine JensonR.
English: If you are pregnant and have taken Ivabradine JensonR, talk to your doctor.
Croatian: Ako ste trudni, a uzeli ste Ivabradine JensonR, obratite se liječniku.
English: The absence of pharmacokinetic difference between the 2 formulations was shown in an open-label randomised two-period cross-over study in 24 adult healthy volunteers.
Croatian: Izostanak razlike u farmakokinetici dvaju formulacija dokazano je u ovorenom, randomiziranom križnom ispitivanju na 24 zdrava dobrovoljca.
English: The most common adverse reactions with this medicine are dose dependent and related to its mode of action:
Croatian: Najčešće nuspojave zabilježene uz primjenu ovog lijeka su ovisne o dozi i povezane s mehanizmom djelovanja lijeka:
English: These trials included a total of 4,111 patients with chronic stable angina pectoris, of whom 2,617 received ivabradine.
Croatian: U tim je studijama sudjelovalo ukupno 4111 bolesnika s kroničnom, stabilnom anginom pektoris, od kojih je 2617 primalo ivabradin.
English: In dogs given ivabradine (doses of 2, 7 or 24 mg/kg/day) for one year, reversible changes in retinal function were observed but were not associated with any damage to ocular structures.
Croatian: U pasa koji su godinu dana dobivali ivabradin (doze od 2, 7 ili 24 mg/kg/dan), zapažene su reverzibilne promjene funkcije mrežnice, no nisu bile povezane s oštećenjem okularnih struktura.
English: Women of child-bearing potential should use appropriate contraceptive measures during treatment (see section 4.3).
Croatian: Žene reproduktivne dobi trebaju koristiti prikladne mjere kontracepcije tijekom liječenja (vidjeti dio 4.3).
English: Use in patients with AV-block of 2nd degree Ivabradine is not recommended in patients with AV-block of 2nd degree.
Croatian: Primjena u bolesnika sa AV-blokom 2. stupnja Ivabradin se ne preporučuje u bolesnika sa AV-blokom 2. stupnja.
English: It is used in adult patients who do not tolerate or cannot take heart medicines called beta-blockers.
Croatian: Lijek se koristi kod odraslih bolesnika koji ne podnose ili ne smiju uzimati lijekove za srce koji se zovu beta-blokatori.
English: Patients received standard care including beta-blockers (89%), ACE inhibitors and/or angiotensin II antagonists (91%), diuretics (83%), and anti-aldosterone agents (60%).
Croatian: Bolesnici su liječeni standardnim pristupom uključujući beta-blokatore (89%), inhibitore ACE i/ili antagoniste angiotenzina II (91%), diuretike (83%) i antagoniste aldosterona (60%).
English: AV 2nd degree block, AV 3rd degree block
Croatian: AV blok 2. stupnja, AV blok 3. stupnja Sindrom bolesnog sinusnog čvora
English: - Chronic heart failure in adult patients whose heart rate is over or equal to 75 beats per minute.
Croatian: - Kronično zatajenje srca kod odraslih bolesnika koji imaju brzinu srčanih otkucaja veću od ili jednaku 75 otkucaja u minuti.
English: Ivabradine JensonR should be taken during meals.
Croatian: Ivabradine JensonR potrebno je uzimati tijekom obroka.
English: The safety and efficacy of ivabradine in the treatment of chronic heart failure in children aged below 18 years have not been established.
Croatian: Sigurnost i djelotvornost ivabradina u liječenju kroničnog zatajenja srca u djece starosti do 18 godina nisu ustanovljene.
English: Ivabradine is not effective in the treatment or prevention of cardiac arrhythmias and likely loses its efficacy when a tachyarrhythmia occurs (e.g. ventricular or supraventricular tachycardia).
Croatian: Ivabradin nije djelotvoran u liječenju ili prevenciji srčanih aritmija i vjerojatno gubi djelotvornost kada nastane tahiaritmija (npr. ventrikulska ili supraventrikulska tahikardija).
English: Rare (may affect up to 1 in 1,000 people): Urticaria, itching, skin reddening, feeling unwell.
Croatian: Rijetko (mogu se javiti u do 1 na 1000 osoba): Urtikarija (koprivnjača), svrbež, crvenilo kože, opće loše osjećanje.
English: They particularly occur within the first 2 to 3 months of treatment initiation.
Croatian: Osobito se javljaju unutar prva 2 ili 3 mjeseca od početka liječenja.
English: The results on the primary endpoint are mainly driven by the heart failure endpoints, hospitalisation for worsening heart failure (absolute risk reduced by 4.7%) and deaths from heart failure (absolute risk reduced by 1.1%).
Croatian: Rezultati vezani za primarnu mjeru ishoda većim dijelom su posljedica mjera ishoda zatajenja srca, hospitalizacija zbog pogoršanja zatajenja srca (smanjenje apsolutnog rizika za 4,7%) i smrti zbog zatajenja srca (smanjenje apsolutnog rizika za 1,1%).
English: UNIQUE IDENTIFIER - 2D BARCODE Applicable only for the outer packaging component: 2D barcode carrying the unique identifier included.
Croatian: 17. JEDINSTVENI IDENTIFIKATOR - 2D BARKOD Primjenjivo samo na vanjsko pakiranje:
English: The European Medicines Agency has waived the obligation to submit the results of studies with the reference medicinal product containing ivabradine in all subsets of the paediatric population in the treatment of angina pectoris (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja referentnog lijeka koji sadrži ivabradin u svim podskupinama pedijatrijske populacije u liječenju angine pektoris (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: In this study, ivabradine was administered as oral liquid formulation or tablet twice daily.
Croatian: U ovom ispitivanju ivabradin se primjenjivao kao oralna otopina ili kao tableta dva puta na dan.
English: It is used in combination with standard therapy, including beta-blocker therapy or when beta-blockers are contraindicated or not tolerated.
Croatian: Lijek se koristi u kombinaciji sa standardnom terapijom, uključujući beta-blokatore ili kada su beta-blokatori kontraindicirani ili se ne podnose.
English: The twice-daily dosing regimen of ivabradine gave uniform efficacy over 24 hours.
Croatian: Režim doziranja ivabradina od dva puta na dan rezultirao je ujednačenom djelotvornosti tijekom 24 sata.
English: However, in the absence of extensive data, non urgent DC-cardioversion should be considered 24 hours after the last dose of ivabradine.
Croatian: No, s obzirom da nema dovoljno podataka, elektivna DC-kardioverzija se može učiniti 24 sata nakon posljednje doze ivabradina.
English: Under triggering circumstances (e.g. rapid changes in luminosity), partial inhibition of Ih by ivabradine underlies the luminous phenomena that may be occasionally experienced by patients.
Croatian: U okolnostima s prisutnim okidačima (npr. brze svjetlosne promjene), djelomična inhibicija Ih struje ivabradinom podliježe svjetlosnim fenomenima koje bolesnici mogu povremeno doživjeti.
English: The safety profile, over one year, was similar to the one described in adult CHF patients.
Croatian: Sigurnosni profil tijekom godine dana sličan je onom opisanom kod odraslih bolesnika koji boluju od kroničnog zatajenje srca.
English: 56 film-coated tablets 98 film-coated tablets 100 film-coated tablets
Croatian: 56 filmom obloženih tableta 98 filmom obloženih tableta 100 filmom obloženih tableta
English: The European Medicines Agency has waived the obligation to submit the results of studies with ivabradine in children aged 0 to less than 6 months in the treatment of chronic heart failure.
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja sa ivabradinom u djece starosti do 6 mjeseci u liječenju kroničnog zatajenja srca.
English: Bradycardia was reported by 17.9% of patients in the ivabradine group (2.1% in the placebo group).
Croatian: Bradikardija je zabilježena u 17,9% bolesnika koji su uzimali ivabradin (2,1% u placebo skupini).
English: Fertility Studies in rats have shown no effect on fertility in males and females (see section 5.3).
Croatian: Plodnost Ispitivanja su pokazala da nema učinka na plodnost u mužjaka i ženki štakora. (vidjeti dio 5.3).
English: Grapefruit juice: ivabradine exposure was increased by 2-fold following the co-administration with grapefruit juice.
Croatian: Sok od grejpa: izloženost ivabradinu se povećala za dva puta nakon istodobne primjene soka od grejpa.
English: They can also be described as a halo, coloured flashes, image decomposition or multiple images.
Croatian: Mogu se također opisati kao aureole oko izvora svjetlosti, raznobojni blijeskovi, rastavljanje slike ili višestruke slike.
English: How to store Ivabradine JensonR Contents of the pack and other information
Croatian: Kako čuvati Ivabradine JensonR Sadržaj pakiranja i druge informacije
English: Special populations - Elderly: no pharmacokinetic differences (AUC and Cmax) have been observed between elderly (≥65 years) or very elderly patients (≥75 years) and the overall population (see section 4.2).
Croatian: Posebne populacije - Starije osobe: između starijih osoba (≥ 65 godina), ili vrlo starih bolesnika (≥ 75 godina) te ukupne populacije nisu zapažene farmakokinetičke razlike (AUC i Cmax) (vidjeti dio 4.2).
English: Ivabradine is indicated: - in adults unable to tolerate or with a contraindication to the use of beta-blockers - or in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose.
Croatian: Ivabradin je indiciran: - u odraslih bolesnika koji ne podnose beta-blokatore ili je njihova primjena kontraindicirana - ili u kombinaciji s beta blokatorima u bolesnika koji nisu adekvatno kontrolirani s optimalnom dozom beta blokatora.
English: Heart rate reduction, as caused by ivabradine, may exacerbate QT prolongation, which may give rise to severe arrhythmias, in particular Torsade de pointes.
Croatian: Smanjenje srčane frekvencije, kao što to uzrokuje ivabradin, može pogoršati QT prolongaciju, što može uzrokovati teške aritmije, osobito Torsade de pointes.
English: What Ivabradine JensonR is and what it is used for What you need to know before you take Ivabradine JensonR How to take Ivabradine JensonR Possible side effects
Croatian: Što je Ivabradine JensonR i za što se koristi Što morate znati prije nego počnete uzimati Ivabradine JensonR Kako uzimati Ivabradine JensonR Moguće nuspojave
English: If the combination appears necessary, close cardiac monitoring is needed (see section 4.4).
Croatian: Ukoliko je ta kombinacija neophodna, potrebno je pažljivo pratiti rad srca (vidjeti dio 4.4).
English: 14 film-coated tablets 14 x 1 film-coated tablets 28 film-coated tablets 56 film-coated tablets 56 x 1 film-coated tablets 98 film-coated tablets 112 film-coated tablets
Croatian: 14 filmom obloženih tableta 14 x 1 filmom obložena tableta 28 filmom obloženih tableta 56 filmom obloženih tableta 56 x 1 filmom obložena tableta 98 filmom obloženih tableta 112 filmom obloženih tableta
English: NAME OF THE MARKETING AUTHORISATION HOLDER Jenson R+ Limited
Croatian: NAZIV NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Jenson R+ Limited
English: Marketing Authorisation Holder Jenson R+ Limited Fishleigh Court,
Croatian: Jenson R+ Limited Fishleigh Court,
English: Given that the heart rate may fluctuate considerably over time, serial heart rate measurements, ECG or ambulatory 24-hour monitoring should be considered when determining resting heart rate before initiation of ivabradine treatment and in patients on treatment with ivabradine when titration is considered.
Croatian: Budući da srčana frekvencija može značajno flukturirati tijekom vremena, mora se razmotriti provođenje serijskog mjerenja srčane frekvencije, putem EKG-a ili ambulantno 24-satno mjerenje kod određivanja srčane frekvencije u mirovanju prije početka liječenja ivabradinom kao i u bolesnika koji uzimaju ivabradin kada se razmatra titriranje doze.
English: What Ivabradine JensonR is and what it is used for
Croatian: Što je Ivabradine JensonR i za što se koristi
English: Ivabradine is approximately 70% plasma protein bound and the volume of distribution at steady-state is close to 100 l in patients.
Croatian: Oko 70% ivabradina veže se na proteine plazme, a volumen distribucije u stanju dinamičke ravnoteže je blizu 100 litara u bolesnika.
English: Linearity/non-linearity The kinetics of ivabradine is linear over an oral dose range of 0.5-24 mg.
Croatian: Linearnost/nelinearnost Kinetika ivabradina je linearna u rasponu oralne doze od 0,5 do 24 mg.
English: The efficacy of 5 and 7.5 mg twice daily was consistent across studies on exercise test parameters (total exercise duration, time to limiting angina, time to angina onset and time to 1 mm ST segment depression) and was associated with a decrease of about 70% in the rate of angina attacks.
Croatian: Djelotvornost doza od 5 i 7,5 mg dva puta na dan na parametre testa fizičkog opterećenja bila je postojana tijekom ispitivanja (ukupno trajanje fizičkog opterećenja, vrijeme do ograničavanja angine, vrijeme do nastupa angine, te vrijeme do depresije ST-segmenta od 1 mm) i povezana sa smanjenjem brzine napadaja angine od oko 70%.
English: Potassium-depleting diuretics (thiazide diuretics and loop diuretics): hypokalaemia can increase the risk of arrhythmia.
Croatian: Diuretici koji troše kalij (tiazidni diuretici i diuretici Henleove petlje): hipokalijemija može povećati rizik nastanka aritmija.
English: The main efficacy criterion was the composite of cardiovascular death, hospitalisation for acute MI or hospitalisation for new onset or worsening heart failure.
Croatian: Glavni kriterij djelotvornosti je bio kompozitni i obuhvaćao je kardiovaskularni mortalitet, hospitalizaciju zbog akutnog infarkta miokarda ili hospitalizaciju zbog novonastalog ili pogoršanja postojećeg srčanog zatajenja.
English: As ivabradine may cause bradycardia, the resulting combination of hypokalaemia and bradycardia is a predisposing factor to the onset of severe arrhythmias, especially in patients with long QT syndrome, whether congenital or substance-induced.
Croatian: Kako ivabradin može uzrokovati bradikardiju, kombinacija hipokalijemije i bradikardije predstavlja predispozirajući čimbenik za nastanak teških aritmija, osobito u bolesnika koji boluju od sindroma dugog QT intervala, neovisno je li sindrom kongenitalan ili uzrokovan lijekovima.
English: The starting dose was 0.02 mg/kg bid in age-subset [6-12]months, 0.05 mg/kg bid in [1-3]years and [3-18]years <40 kg, and 2.5 mg bid in [3-18]years and ≥40 kg.
Croatian: Početna doza bila je 0,02 mg/kg/dan dva puta na dan u starosnoj podskupini [6-12] mjeseci, 0,05 mg/kg/dan dva puta na dan u starosnim podskupinama [1-3] godine i [3-18] godina s < 40 kg te 2,5 mg/kg/dan dva puta na dan u starosnoj podskupini [3-18] godina s ≥ 40 kg.
English: Ivabradine JensonR (ivabradine) is a heart medicine used to treat: - Symptomatic stable angina pectoris (which causes chest pain) in adult patients whose heart rate is over or equal to 70 beats per minute.
Croatian: Ivabradine JensonR (ivabradin) je lijek za srce koji se primjenjuje u liječenju: - Simptomatske stabilne angine pektoris (koja uzrokuje bolove u prsnom košu) u odraslih bolesnika koji imaju brzinu srčanih otkucaja jednaku ili veću od 70 otkucaja u minuti.
English: No data are available in patients with severe hepatic impairment (see sections 4.2 and
Croatian: O bolesnicima s teškim oštećenjem jetre nema podataka (vidjeti dijelove 4.2 i 4.3).
English: There was a significant improvement in NYHA class at last recorded value, 887 (28%) of patients on ivabradine improved versus 776 (24%) of patients on placebo (p = 0.001).
Croatian: Zabilježeno je značajno poboljšanje NYHA stupnja kod posljednje zabilježene vrijednosti, 887 (28%) bolesnika liječenih ivabradinom postiglo je poboljšanje za razliku od 776 (24%) bolesnika u placebo skupini (p=0,001).
English: - Paediatric population: The pharmacokinetic profile of ivabradine in paediatric chronic heart failure patients aged 6 months to less than 18 years is similar to the pharmacokinetics described in adults when a titration scheme based on age and weight is applied.
Croatian: - Pedijatrijska populacija: Farmakokinetički profil ivabradina u pedijatrijskih bolesnika koji boluju od kroničnog zatajenja srca starosti od 6 do 18 mjeseci sličan je farmakokinetičkom profilu opisanom u odraslih kada se primjenjuje titracijska shema na temelju starosti i težine.
English: A significant effect was observed on the primary composite endpoint in the overall group of patients receiving beta-blocker therapy (hazard ratio: 0.85, 95% CI [0.76; 0.94]).
Croatian: Značajan učinak na primarnu kompozitnu mjeru ishoda je zabilježen u cjelokupnoj skupini bolesnika koji primaju terapiju beta-blokatorima (omjer hazarda (HR): 0,85, 95%CI [0,76;0,94]).
English: If any of the above applies to you, talk straight away to your doctor before or while taking Ivabradine JensonR.
Croatian: Ako se bilo što od gore navedenog odnosi na Vas, razgovarajte o tome s liječnikom prije nego što počnete uzimati Ivabradine JensonR, ili kada ga već uzimate.
English: The long-term effects of ivabradine on growth, puberty and general development as well as the long-term efficacy of therapy with ivabradine in childhood to reduce cardiovascular morbidity and mortality have not been studied.
Croatian: Nisu istraženi dugotrajni učici ivabradina na rast, pubertet i opći razvoj kao ni dugotrajna učinkovitost liječenja ivabradinom u djetinjstvu na smanjenje kardiovaskularnog pobola ni smrtnosti.
English: What Ivabradine JensonR contains - The active substance is ivabradine (as hydrochloride).
Croatian: Što Ivabradine JensonR sadrži - Djelatna tvar je ivabradin (u obliku ivabradinklorida).
English: To date, there is no evidence of a toxic effect of ivabradine on the retina, but the effects of long-term ivabradine treatment beyond one year on retinal function are currently not known.
Croatian: Nije dokazan toksičan učinak ivabradina na mrežnicu, ali su učinci na funkciju mrežnice nakon dugotrajnog liječenja ivabradinom, dulje od jedne godine trenutno nepoznati.
English: itraconazole), macrolide antibiotics (clarithromycin, erythromycin per os, josamycin, telithromycin),
Croatian: (ketokonazol, itrakonazol), makrolidni antibiotici (klaritromicin, eritromicin per os, jozamicin,
English: A large outcome study, SIGNIFY, was performed in 19,102 patients with coronary artery disease and without clinical heart failure (LVEF >40%), on top of optimal background therapy.
Croatian: Veliko ispitivanje ishoda, SIGNIFY, provedeno je u 19102 bolesnika s koronarnom arterijskom bolešću bez kliničkih znakova zatajenja srca (LVEF > 40%) uz optimalnu osnovnu terapiju.
English: The usual recommended starting dose is one tablet of Ivabradine JensonR 5 mg twice daily increasing if necessary to one tablet of Ivabradine JensonR 7.5 mg twice daily.
Croatian: Uobičajena preporučena početna doza je jedna tableta lijeka Ivabradine JensonR 5 mg dva puta na dan, koja se, ako je potrebno, povećava na jednu tabletu lijeka Ivabradine JensonR od 7,5 mg dva puta na dan.
English: For bottles only: After first opening, use within 6 months.
Croatian: 2 godine Samo za boce: nakon prvog otvaranja iskoristiti u roku od 6 mjeseci.
English: Ivabradine JensonR may cause temporary luminous visual phenomena (a temporary brightness in the field of vision, see “Possible side effects”).
Croatian: Ivabradine JensonR može uzrokovati privremene vidne poremećaje (prolazna povećana svjetlost u ograničenom dijelu vidnoga polja, (vidjeti dio 4 “Moguće nuspojave”).
English: - CYP3A4 inducers: CYP3A4 inducers (e.g. rifampicin, barbiturates, phenytoin, Hypericum perforatum [St John's wort]) may decrease ivabradine exposure and activity.
Croatian: - CYP3A4 induktori: CYP3A4 induktori (npr. rifampicin, barbiturati, fenitoin, Hypericum perforatum [gospina trava]) mogu smanjiti izloženost ivabradinu i njegovu aktivnost.
English: The PK/PD relationship of ivabradine in paediatric chronic heart failure patients aged 6 months to less than 18 years is similar to the PK/PD relationship described in adults.
Croatian: PK/PD odnos ivabradina u pedijatrijskih bolesnika koji boluju od kroničnog zatajenja srca starosti od 6 do 18 mjeseci sličan je PK/PD odnosu opisanom u odraslih.