FrancophonIA/ELRC3.0 huggingface dataset:
English: The evaluation of the risk-benefit ratio should be made on an individual basis outweighing the respective risk of hydroxycarbamide therapy against the switch to a blood transfusion programme.
Slovenian: Razmerje med koristjo in tveganjem je treba oceniti individualno in pretehtati tveganje zdravljenja s hidroksikarbamidom v primerjavi s prehodom na program transfuzije krvi.
English: Any person, in particular pregnant women, who are not taking Siklos should avoid direct contact with the parts when breaking a tablet.
Slovenian: Osebe, še posebej nosečnice, ki ne jemljejo zdravila Siklos, se morajo izogibati direktnemu stiku s posameznimi deli tablete, kadar tablete lomijo.
English: It is recommended that blood counts are monitored for several weeks after overdose since recovery may be delayed.
Slovenian: Od prevelikega odmerjanja naprej je več tednov priporočljivo opazovanje krvne slike, ker lahko pride do zakasnitve okrevanja.
English: HbF interferes with the polymerisation of HbS and thus impedes the sickling of red blood cell.
Slovenian: HbF ovira polimerizacijo HbS in na ta način preprečuje nastanek srpaste oblike rdeče krvničke.
English: In patients with Sickle Cell Syndrome hydroxycarbamide was eliminated with a half-life of approximately six to seven hours, which is longer than reported in other indications.
Slovenian: Pri bolnikih s srpastoceličnim sindromom se je bil hidroksikarbamid izločil z razpolovnim časom približno šest do sedem ur, kar je dlje, kot so poročali pri drugih indikacijah.
English: Siklos may hence decrease the ability of men to father children.
Slovenian: Siklos lahko vpliva na sposobnost moških zaploditi otroka.
English: When the maximum tolerated dose is not reached transient myelotoxicity usually occurs in less than 10% of patients, while under the maximum tolerated dose more than 50% can experience reversible bone marrow suppression.
Slovenian: Kadar najvišji dovoljeni odmerek ni dosežen, se prehodna mielotoksičnost pojavi pri manj kot 10 % bolnikov, medtem ko lahko pri najvišjem dovoljenem odmerku pride do reverzibilne depresije kostnega mozga pri več kot 50 % bolnikov.
English: People who are not taking Siklos and in particular pregnant women should avoid being in contact with hydroxycarbamide.
Slovenian: Ljudje, ki ne jemljejo zdravila Siklos, še posebno nosečnice, se morajo izogibati stiku s hidroksikarbamidom.
English: Also, in rats testicular atrophy with decreased spermatogenesis occurred, while in dogs reversible spermatogenic arrest was noted.
Slovenian: Pri podganah je prišlo tudi do atrofije mod z zmanjšano spermatogenezo, medtem ko so pri psih opazili reverzibilni zastoj spermatogeneze.
English: Luxembourg/Luxemburg
Slovenian: Luxembourg/Luxemburg Addmedica
English: Patients treated with hydroxycarbamide in combination with didanosine, stavudine, and indinavir showed a median decline in CD4 cells of approximately 100/mm3.
Slovenian: Pri bolnikih, zdravljenih s hidroksikarbamidom v kombinaciji z didanozinom, s stavudinom in z indinavirom, so ugotovili mediano upadanje števila celic CD4 za približno 100/mm3.
English: Based on the limited amount of available information, in case of an exposure to hydroxycarbamide of pregnant female patients or pregnant partners of male patients, treated by hydroxycarbamide, a careful follow-up with adequate clinical, biological and ultrasonographic examinations should be considered.
Slovenian: Na podlagi omejenih razpoložljivih podatkov o primerih izpostavljenosti nosečih bolnic hidroksikarbamidu ali nosečih partneric bolnikov, zdravljenih s hidroksikarbamidom, je treba razmisliti o skrbnem spremljanju z ustreznimi kliničnimi, biološkimi in ultrazvočnimi preiskavami.
English: Siklos therapy can then be re-initiated at a lower dose (see section 4.2).
Slovenian: Nato se terapijo z zdravilom Siklos lahko ponovno začne z nekoliko nižjim odmerkom (glejte poglavje 4.2).
English: Treatment of overdose consists of gastric lavage, followed by symptomatic treatment and control of bone marrow function.
Slovenian: Zdravljenje prevelikega odmerjanja obsega gastrično lavažo, kateri sledita simptomatsko zdravljenje in kontrola funkcije kostnega mozga.
English: Very common reversible oligo- and azoo-spermia have been observed in man, although these disorders are also associated with the underlying disease.
Slovenian: Opazili so zelo pogoste reverzibilne primere oligospermije in azoospermije pri ljudeh, čeprav sta ti bolezni povezani tudi z osnovno boleznijo.
English: Haematologic recovery usually occurs within two weeks.
Slovenian: Do izboljšanja hematološkega statusa ponavadi pride v roku dveh tednov.
English: Siklos has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo Siklos ima blag vpliv na sposobnost vožnje in upravljanja strojev.
English: Pharmacotherapeutic group: Antineoplastic agents, other antineoplastic agents, ATC code: L01XX05.
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe (citostatiki), druga zdravila z delovanjem na novotvorbe (citostatiki), oznaka ATC: L01XX05.
English: The yearly frequency of acute chest syndrome was also reduced by 25 to 33% under hydroxycarbamide in several studies.
Slovenian: Tudi letna pogostnost akutnega sindroma bolečine v prsih se je v nekaterih študijah prav tako zmanjšala za 25 do 33 % s hidroksikarbamidom.
English: Patients should be advised not to drive or operate machines, if dizziness is experienced while taking Siklos.
Slovenian: Bolnikom je treba svetovati, naj ne vozijo avtomobila in ne upravljajo s stroji, če so omotični, kadar jemljejo zdravilo
English: Cardiovascular effects and haematological changes were observed in some species.
Slovenian: Pri nekaterih vrstah so opazili kardiovaskularne učinke in hematološke spremembe.
English: Other known pharmacological effects of hydroxycarbamide which may contribute to its beneficial effects in Sickle Cell Syndrome include decrease of neutrophils, increase of the water content of erythrocytes, increase of the deformability of sickled cells, and altered adhesion of red blood cells to the endothelium.
Slovenian: Drugi znani farmakološki učinki hidroksikarbamida, ki utegnejo prispevati k njegovim koristnim učinkom pri srpastoceličnem sindromu, vključujejo znižanje števila nevtrofilnih levkocitov, zvišanje vsebnosti vode v eritrocitih, zvišanje deformabilnosti srpastih celic in spremenjeno adhezijo rdečih krvničk na endotel.
English: Unused broken tablets must be replaced in the bottle and must be used within three months.
Slovenian: Neporabljene prelomljene tablete zdravila morate shraniti nazaj v plastenko in uporabiti v treh mesecih.
English: If you forget to take Siklos
Slovenian: Če ste pozabili vzeti zdravilo Siklos
English: There are no data that support specific dose adjustments in patients with hepatic impairment.
Slovenian: Ni podatkov, ki podpirajo specifično prilagajanje odmerka pri bolnikih z jetrno okvaro.
English: Long-term data on the continued use of hydroxycarbamide in patients with Sickle Cell Syndrome are available in children and adolescents, with a follow-up of 12 years in children and adolescents and over 13 years in adults.
Slovenian: Dolgoročni podatki o neprekinjeni uporabi hidroksikarbamida pri bolnikih s srpastoceličnim sindromom so na voljo za otroke in mladostnike, 12-letno zdravljenje pri otrocih in mladostnikih, in za odrasle več kot 13-letno zdravljenje.
English: In the event a patient does still not respond when treated with the maximum dose of hydroxycarbamide (35 mg/kg b.w./day) over three to six months, permanent discontinuation of Siklos should be considered.
Slovenian: Če se bolnik še vedno ne odziva, ko zdravljenje z najvišjim odmerkom hidroksikarbamida (35 mg/kg TM/dan) traja že tri do šest mesecev, je treba razmisliti o trajni prekinitvi jemanja zdravila
English: Concomitant use of hydroxycarbamide with a live virus vaccine may potentiate the replication of the vaccine virus and/or may increase the adverse reaction of the vaccine virus, because normal defence mechanisms may be suppressed by hydroxycarbamide therapy.
Slovenian: Hkratna uporaba hidroksikarbamida s cepivi z živim virusom lahko okrepi razmnoževanje virusa cepiva in/ali poveča neželene učinke virusa cepiva, zato ker lahko terapija s hidroksikarbamidom zavira normalni obrambni mehanizem.
English: In the human, according to a retrospective analysis of a cohort of 123 adult patients treated with hydroxycarbamide, twenty-three pregnancies have been reported from 15 women treated with hydroxycarbamide and partners of 3 men treated with hydroxycarbamide.
Slovenian: Pri človeku so v retrospektivnih analizah kohorte 123 odraslih bolnikov, zdravljenih s hidroksikarbamidom, poročali o triindvajsetih nosečnostih pri 15 ženskah, zdravljenih s hidroksikarbamidom, in pri partnerkah 3 moških, zdravljenih s hidroksikarbamidom.
English: Each half of tablet is embossed “H” on one side.
Slovenian: Vsaka polovica tablete ima na eni strani vtisnjeno črko »H«.
English: In addition hydroxycarbamide causes an immediate inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or protein.
Slovenian: Poleg tega hidroksikarbamid neposredno ovira sintezo DNA, ker deluje kot inhibitor ribonukleotid reduktaze, ne da bi posegal v sintezo ribonukleinske kisline ali proteinov.
English: • Place the required dose (preferably broken if Siklos 1000 mg tablet is used) in a teaspoon and add some water.
Slovenian: • Potrebni odmerek (če uporabljate Siklos 1000 mg tablete, jih je najbolje prelomiti) dajte na čajno žličko in dolijte nekoliko vode.
English: If blood counts are within the toxic range Siklos should be temporarily discontinued until blood counts recover.
Slovenian: Če je krvna slika v toksičnem območju, je treba jemanje zdravila Siklos začasno prekiniti, dokler se krvna slika ne izboljša.
English: Severe renal impairment (creatinine clearance < 30 ml/min).
Slovenian: Huda ledvična okvara (očistek kreatinina < 30 ml/min).
English: EXP: In-use shelf life of broken tablets: 3 months
Slovenian: Rok uporabe prelomljenih tablet: 3 mesece
English: Teratogenicity was characterised by partially ossified cranial bones, absence of eye sockets, hydrocephaly, bipartite sternebrae, missing lumbar vertebrae.
Slovenian: Za teratogenost so bile značilne delno osificirane lobanjske kosti, odsotnost očesnih votlin, hidrocefalija, dvodelne sternebrae, manjkajoča ledvena vretenca.
English: In adults with Sickle Cell Syndrome, mean cumulative urinary hydroxycarbamide excretion was 62% of the administered dose at 8 hours, and thus higher than in cancer patients (35-40%).
Slovenian: Pri odraslih s srpastoceličnim sindromom je povprečno urinarno izločanje hidroksikarbamida znašalo 62 % danega odmerka v 8 urah in bilo potemtakem višje kot pri bolnikih z rakom (35 - 40 %).
English: 30 tablets
Slovenian: 90 tablet
English: The active substance of Siklos, hydroxycarbamide, is a substance which inhibits growth and proliferation of some cells, such as blood cells.
Slovenian: Učinkovina zdravila Siklos, hidroksikarbamid, je snov, ki zavira rast in razmnoževanje nekaterih celic, npr. krvnih celic.
English: Inflammation of the skin causing red scaly patches and possibly occurring together with pain in the joints.
Slovenian: Vnetje kože, ki povzroča nastajanje rdečih, luskastih zaplat in se lahko pojavlja skupaj z bolečinami v sklepih.
English: If you take more Siklos than you should
Slovenian: Če ste vzeli večji odmerek zdravila Siklos, kot bi smeli
English: If you stop taking Siklos
Slovenian: Če ste prenehali jemati zdravilo Siklos
English: An erythema caused by radiation therapy may be aggravated by hydroxycarbamide.
Slovenian: Eritemi, ki so posledica radioaktivne terapije, se zaradi hidroksikarbamida lahko poslabšajo.
English: At concentrations ranging from 10 to 300 µM, hydroxycarbamide does not stimulate the in vitro ATPase activity of recombinant human P glycoprotein (PGP), indicating that hydroxycarbamide is not a PGP substrate.
Slovenian: Hidroksikarbamid v koncentracijah od 10 do 300 µM ne spodbuja in vitro aktivnosti ATPaze rekombinantnega humanega P-glikoproteina (PgP), kar kaže na to, da hidroksikarbamid ni substrat PgP.
English: The oral bioavailability of hydroxycarbamide is almost complete as assessed in indications other than Sickle Cell Syndrome.
Slovenian: Peroralna biološla uporabnost hidroksikarbamida je skoraj popolna, kot je bilo ugotovljeno za druge indikacije kot srpastocelični sindrom.
English: One of the mechanisms by which hydroxycarbamide acts is the elevation of foetal haemoglobin (HbF) concentrations in sickle cell patients.
Slovenian: Eden od mehanizmov, po katerem hidroksikarbamid deluje, je zvišanje koncentracije fetalnega hemoglobina (HbF) pri bolnikih s srpastoceličnim sindromom.
English: The tablet can be divided into four equal parts.
Slovenian: Tableto je možno razdeliti na štiri enake dele.
English: Recently, hydroxycarbamide has shown to be associated with the generation of nitric oxide suggesting that nitric oxide stimulates cyclic guanosine monophosphatase (cGMP) production, which then activates a protein kinase and increases the production of HbF.
Slovenian: V zadnjem času se je pokazalo, da je hidroksikarbamid povezan z nastajanjem dušikovega oksida, kar kaže na to, da dušikov oksid spodbuja proizvodnjo cikličnega gvanozin monofosfata (cGMP), ki nato aktivira proteinsko kinazo in poveča nastajanje HbF.
English: As long as the patient responds to therapy either clinically or haematologically (e.g. increase of haemoglobin F (HbF), Mean Corpuscular Volume (MCV), neutrophil count) the dose of Siklos should be maintained.
Slovenian: Dokler se bolnik na terapijo bodisi klinično bodisi hematološko (npr. zvišanje koncentracije fetalnega hemoglobina F (HbF), povprečnega volumna eritrocitov (PVE), števila nevtrofilnih levkocitov) odziva, je treba odmerek zdravila Siklos vzdrževati.
English: Hydroxycarbamide may decrease sperm production in male patients while they are being treated.
Slovenian: Hidroksikarbamid lahko zmanjša nastajanje sperme pri moških bolnikih, medtem ko se zdravijo.
English: These vasculitic toxicities were reported most often in patients with a history of, or currently receiving, interferon therapy.
Slovenian: O teh toksičnih vaskulitisih so najpogosteje poročali pri bolnikih, ki so bili v preteklosti ali takrat zdravljeni z interferonom.
English: Due to potentially severe clinical outcomes for the cutaneous vasculitic ulcers reported in patients with myeloproliferative disease, hydroxycarbamide should be discontinued and/or its dose reduced if cutaneous vasculitic ulcerations develop.
Slovenian: Zaradi potencialno hudih kliničnih izidov kožnih vaskulitičnih ulkusov, o katerih so poročali pri bolnikih z mieloproliferativno boleznijo, je treba zdravljenje s hidroksikabamidom prekiniti in/ali znižati njegov odmerek, če pride do nastanka kožnih vaskulitičnih ulkusov.
English: Anyone handling Siklos should wash their hands before and after contact with the tablets.
Slovenian: Vsi, ki rokujejo z zdravilom Siklos, si morajo pred stikom s tabletami in po njem umiti roke.
English: Women of childbearing potential/Contraception in males and females Women of childbearing age receiving hydroxycarbamide should be advised to avoid becoming pregnant, and to inform the treating physician immediately should this occur.
Slovenian: Ženske v rodni dobi/Kontracepcija pri moških in ženskah Ženskam v rodni dobi je treba svetovati, da naj med zdravljenjem s hidroksikarbamidom ustrezno poskrbijo za preprečevanje zanositve, in da naj takoj obvestijo lečečega zdravnika, če zanosijo.
English: Siklos is used to prevent painful crises, including sudden chest pain, caused by Sickle Cell disease, in adults, adolescents and children older than 2 years.
Slovenian: Zdravilo Siklos se uporablja za preprečevanje bolečih kriz, vključno z nenadno bolečino v prsih, ki so posledica srpastoceličnega sindroma, pri odraslih, mladostnikih in otrocih, starejših od 2 let.
English: Each quarter of tablet is embossed “T” on one side.
Slovenian: Vsaka četrtina tablete ima na eni strani izbočeno črko "T".
English: Patients with normal (creatinine clearance CrCl>80 ml/min), mild (CrCl 60-80 ml/min), moderate (CrCl 30 - 60 ml/min), or severe (<30 ml/min) renal impairment received hydroxycarbamide as a single dose of 15 mg/kg b.w.
Slovenian: Bolniki z normalno (očistek kreatinina CrCl > 80 ml/min), blago (CrCl 60 - 80 ml/min), zmerno (CrCl 30 - < 60 ml/min) ali hudo (< 30 ml/min) okvaro ledvic so prejeli hidroksikarbamid v obliki enkratnega odmerka 15 mg/kg TM, z uporabo 200 mg, 300 mg ali 400 mg kapsul.
English: Prophylactic administration of folic acid is recommended.
Slovenian: Priporočljivo je preventivno dajanje folne kisline.
English: Concurrent use of hydroxycarbamide and other myelosuppressive medicinal products or radiation therapy may increase bone marrow depression, gastro-intestinal disturbances or mucositis.
Slovenian: Sočasna uporaba hidroksikarbamida in drugih mielosupresivnih zdravil ali rentgenske terapije lahko poveča depresijo kostnega mozga, motnje prebavil ali mukozitis.
English: Treatment with Siklos should be initiated by a physician experienced in the management of Sickle Cell Syndrome.
Slovenian: Zdravljenje z zdravilom Siklos mora začeti zdravnik, izkušen v obravnavanju srpastoceličnega sindroma.
English: These adverse reactions are expected based on the pharmacology of hydroxycarbamide.
Slovenian: Te neželene učinke se pričakuje na podlagi farmakologije hidroksikarbamida.
English: As evaluated in a further study, in patients with a CrCl<60 ml/min the area under the curve was approximately 51% higher than in patients with a CrCl ≥60 ml/min, which suggests that a dose reduction of hydroxycarbamide by 50% may be appropriate in patients with a CrCl < 60 ml/min.
Slovenian: Kot so ugotovili v nadaljnji študiji, je bila pri bolnikih s CrCl < 60 ml/min površina pod krivuljo za približno 51 % višja kot pri bolnikih s CrCl ≥ 60 ml/min, kar kaže na to, da je pri bolnikih s CrCl < 60 ml/min primerno zmanjšati odmerek hidroksikarbamida za 50 %.
English: Due to safety considerations, Siklos is contraindicated in patients with severe hepatic impairment (see sections 4.3 and 4.4).
Slovenian: Zaradi skrbi glede varnosti je Siklos kontraindiciran pri bolnikih s hudo jetrno okvaro (glejte poglavji 4.3 in 4.4).
English: Wash your hands before and after contact with the tablets.
Slovenian: Pred stikom s tabletami in po njem si umijte roke.
English: This leaflet was last approved in
Slovenian: Navodilo je bilo nazadnje revidirano dne.
English: In patients, whose CrCl was below 60 ml/min or patients with end-stage renal disease the mean exposure to hydroxycarbamide was approximately 64% higher than in patients with normal renal function.
Slovenian: Pri bolnikih, katerih CrCl je bil pod 60 ml/min, ali pri bolnikih z ledvično boleznijo v zadnjem stadiju je bila povprečna izpostavljenost hidroksikarbamidu za približno 64 % višja kot pri bolnikih z normalno ledvično funkcijo.
English: These effects lead to a reduction of circulating red, white and coagulation blood cells (myelosuppressive effect).
Slovenian: To vodi do zmanjšanja števila krožečih rdečih in belih krvničk ter krvnih ploščic (mielosupresivni učinek).
English: Since there is no available data in patients with mild to moderate liver impairment, Siklos should be used with caution (see section 4.2).
Slovenian: Ker ni podatkov za bolnike z blago do zmerno jetrno okvaro, je treba zdravilo Siklos uporabljati previdno (glejte poglavje 4.2).
English: The extent of protein binding of hydroxycarbamide is unknown.
Slovenian: Obseg vezave hidroksikarbamida na proteine ni znan.
English: Embryotoxicity was characterized by decreased foetal viability, reduced live litter sizes, and developmental delays.
Slovenian: Za embriotoksičnost so bili značilni zmanjšanje viabilnosti plodu, zmanjšano število živih mladičev v leglu in upočasnitve razvoja.
English: Hydroxycarbamide administered to male rats at 60 mg/kg b.w./day (about double the recommended usual maximum dose in humans) produced testicular atrophy, decreased spermatogenesis and significantly reduced their ability to impregnate females.
Slovenian: Hidroksikarbamid, ki so ga dali podganjim samcem v odmerku 60 mg/kg TM/dan (približno dvakratni odmerek priporočenega najvišjega odmerka za ljudi), je povzročil atrofijo mod, zmanjšanje spermatogeneze in signifikantno zmanjšano sposobnost za oploditev samic.
English: Haemoglobin < 4.5 g/dl
Slovenian: < 4,5 g/dl retikulociti
English: The most common symptoms of overdose with Siklos are: - Redness of the skin, - Soreness (touch is painful) and swelling of the palms of hands and soles of feet followed by the hands and feet becoming scaly, - Skin becoming strongly pigmented (locally changes of colour), - Soreness or swelling in the mouth.
Slovenian: Najpogostejši simptomi za prevelik odmerek zdravila Siklos so: - Pordela koža, - Občutljivost (dotik je boleč) in otekanje dlani in podplatov, kateremu sledi luščenje rok in stopal, - Koža postane močno pigmentirana (lokalne spremembe barve), - Občutljivost in otekline v ustih.
English: Treatment with Siklos should be discontinued if bone marrow function is markedly depressed.
Slovenian: Zdravljenje z zdravilom Siklos je treba prekiniti, če je delovanje kostnega mozga opazno zavrto.
English: After oral administration of 20 mg/kg of hydroxycarbamide, a rapid absorption is observed with peak plasma levels of about 30 mg/L occurring after 0.75 and 1.2 h in children and adult patients with Sickle Cell Syndrome, respectively.
Slovenian: Po peroralnem dajanju 20 mg/kg hidroksikarbamida se opazi hitra absorbcija z najvišjimi vrednostmi v plazmi okrog 30 mg/l do katerih pride po 0,75 h pri otrocih in 1,2 h pri odraslih bolnikih s srpastoceličnim sindromom.
English: Acute chest syndrome is a frequent life-threatening complication of Sickle Cell Syndrome and is characterised by chest pain or fever or dyspnoea with recent infiltrate on chest X-ray.
Slovenian: Akutni sindrom bolečine v prsih je pogost življenjsko nevaren zaplet srpastoceličnega sindroma, zanj pa so značilni bolečina v prsih ali povišana telesna temperatura ali dispneja z infiltratom, videnim na zadnji rentgenski sliki prsnega koša.
English: - if you have a liver disease, - if you have a kidney disease, - if you have leg ulcers, - if you are taking other myelosuppressive medicines (decrease production of red, white, or coagulating blood cells) or receiving radiation therapy, - if you have a known lack of vitamin B12 or folate.
Slovenian: - če imate jetrno bolezen, - če imate ledvično bolezen, - če imate ulkuse (razjede) na nogah, - če jemljete druga mielosupresivna zdravila (zmanjšujejo tvorbo rdečih ali belih krvničk ali krvnih ploščic) ali vas zdravijo z obsevanjem (radioterapijo), - če imate znano pomanjkanje vitamina B12 ali folatov.
English: 2 The macrocytosis caused by hydroxycarbamide is not vitamin B12 or folic acid dependent.
Slovenian: 2 Makrocitoza, ki je posledica hidroksikarbamida, ni odvisna od vitamina B12 ali folne kisline.
English: In a repeated dose study in adult patients with Sickle Cell Syndrome approximately 60% of the hydroxycarbamide dose was detected in urine at steady state.
Slovenian: V študiji s ponavljajočimi odmerki pri odraslih bolnikih s srpastoceličnim sindromom so v stanju dinamičnega ravnovesja približno 60 % hidroksikarbamida odkrili v urinu.
English: Isolated cases of malignant disease of blood cells (leukaemia), skin cancer in elderly patients, viral infection with Parvovirus B19, bleeding, gastrointestinal disturbances, vomiting, skin dryness, fever, absence of menstrual cycles (amenorrhoea), and weight gain.
Slovenian: Posamezni primeri malignih bolezni krvnih celic (levkemija), kožni rak pri starejših bolnikih, virusne okužbe s Parvovirus B19, krvavitev, prebavne motnje, bruhanje, suha koža, povišana telesna temperatura, izostanek menstrualnih ciklov (amenoreja) in povečana telesna masa.