FrancophonIA/ELRC3.0 huggingface dataset:
English: • Do not mix Saxenda up with other medicines that you inject (e.g. insulins).
Danish: • Du må ikke opblande Saxenda med andre lægemidler til injektion (f.eks. insuliner).
English: • Trial 1 (SCALE Obesity & Pre-Diabetes - 1839): A total of 3,731 patients with obesity (BMI
Danish: • Studie 1 (SCALE Obesity & Pre-Diabetes - 1839): I alt blev 3.731 patienter med adipositas
English: Overall, gastrointestinal reactions were the most frequently reported adverse reactions during treatment (67.9%) (see section ‘Description of selected adverse reactions').
Danish: Samlet set var de hyppigst rapporterede bivirkninger under behandling med Saxenda gastrointestinale bivirkninger (67,9%) (se punktet ‘Beskrivelse af udvalgte bivirkninger').
English: Following a [3H]-liraglutide dose, intact liraglutide was not detected in urine or faeces.
Danish: Efter en dosis [3H]-liraglutid blev der ikke konstateret intakt liraglutid i urin eller fæces.
English: Saxenda has no or negligible influence on the ability to drive and use machines.
Danish: Saxenda påvirker ikke eller kun i ubetydelig grad evnen til at føre motorkøretøj og betjene maskiner.
English: A mean increase in heart rate from baseline of 2.5 beats per minute (ranging across trials from 1.6 to 3.6 beats per minute) has been observed with liraglutide in clinical phase 3 trials.
Danish: En gennemsnitlig stigning i hjertefrekvensen på 2,5 slag i minuttet i forhold til baseline (varierende i studierne fra 1,6 til 3,6 slag i minuttet) er blevet observeret i kliniske fase 3-studier med liraglutid.
English: Patients should be informed of the symptoms of increased heart rate (palpitations or feelings of a racing heartbeat while at rest).
Danish: Patienterne skal informeres om symptomerne på øget hjertefrekvens (palpitationer eller en følelse af hurtige hjerteslag i hvile).
English: If pancreatitis is suspected, liraglutide should be discontinued; if acute pancreatitis is confirmed, liraglutide should not be restarted.
Danish: Hvis der er mistanke om pankreatitis, skal liraglutid seponeres; hvis akut pankreatitis bekræftes, må behandling med liraglutid ikke påbegyndes igen.
English: Therapeutic experience in patients ≥75 years of age is limited and use in these patients is not recommended (see sections 4.4 and 5.2).
Danish: Erfaringen med behandling af patienter ≥75 år er begrænset, og brug hos disse patienter anbefales ikke (se pkt.
English: Clinical trials suggest that liraglutide improves and sustains beta-cell function, according to HOMA-B and the proinsulin-to-insulin ratio.
Danish: Kliniske studier tyder på, at liraglutid forbedrer og opretholder betacellefunktionen ifølge en homeostasemodelvurdering for betacellefunktion (HOMA-B) og proinsulin/insulin-forholdet.
English: Treatment with Saxenda should be discontinued after 12 weeks on the 3.0 mg/day dose if patients have not lost at least 5% of their initial body weight.
Danish: Saxenda bør seponeres efter 12 ugers behandling med en dosis på 3,0 mg/dag, hvis patienten ikke har tabt mindst 5% af den initiale legemsvægt.
English: Novo Nordisk A/S Novo Allé 2880 Bagsværd Denmark
Danish: Novo Nordisk A/S Novo Allé 2880 Bagsværd Danmark
English: Cartridge (type 1 glass) with a plunger (bromobutyl) and a laminate rubber sheet (bromobutyl/polyisoprene) contained in a pre-filled multidose disposable pen made of polypropylene, polyacetal, polycarbonate and acrylonitrile butadiene styrene.
Danish: Cylinderampul (type 1-glas) med et stempel (bromobutyl) og en lamineret gummiplade (bromobutyl/polyisopren) i en fyldt engangspen til flergangsbrug af polypropylen, polyacetal, polycarbonat og acrylonitril-butadien-styren.
English: A. MANUFACTURERS OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Danish: A. FREMSTILLERE AF DET BIOLOGISK AKTIVE STOF OG FREMSTILLERE ANSVARLIGE FOR BATCHFRIGIVELSE
English: Age had no clinically relevant effect on the pharmacokinetics of liraglutide based on the results from a population pharmacokinetic analysis of data from overweight and obese patients (18 to 82 years).
Danish: Alder havde ingen klinisk relevant effekt på farmakokinetikken af liraglutid baseret på resultaterne fra en farmakokinetisk populationsanalyse af data fra overvægtige og adipøse patienter (18 til 82 år).
English: Injection site reactions have been reported in patients treated with Saxenda.
Danish: Der er rapporteret reaktioner på injektionsstedet hos patienter, der er i behandling med Saxenda.
English: Substances added to Saxenda may cause degradation of liraglutide.
Danish: Lægemidler, der gives i tillæg til Saxenda, kan medføre nedbrydning af liraglutid.
English: Treatment with liraglutide significantly improved systolic blood pressure and waist circumference compared with placebo (tables 3, 4 and 5).
Danish: Behandling med liraglutid forbedrede systolisk blodtryk og livvidde signifikant sammenlignet med placebo (tabel 3, 4 og 5).
English: Dizziness Dysgeusia
Danish: Svimmelhed Dysgeusi
English: If an anaphylactic reaction is suspected, liraglutide should be discontinued and treatment should not be restarted (see section 4.3).
Danish: Hvis der er mistanke om en anafylaktisk reaktion, skal liraglutid seponeres og behandling bør ikke genstartes (se pkt.
English: Use of liraglutide is not recommended in these patients since it is associated with transient gastrointestinal adverse reactions, including nausea, vomiting and diarrhoea.
Danish: Liraglutid anbefales ikke til sådanne patienter, da det er forbundet med forbigående gastrointestinale bivirkninger, herunder kvalme, opkastning og diarré.
English: Saxenda was evaluated for safety in 5 double-blind, placebo controlled trials that enrolled 5,813 obese patients or overweight patients with at least one weight-related comorbidity.
Danish: Saxenda blev evalueret med henblik på sikkerhed i 5 dobbeltblindede placebokontrollerede studier, der omfattede 5.813 adipøse patienter eller overvægtige patienter med mindst én vægtrelateret komorbiditet.
English: When your pen contains less than 3.0 mg the dose counter stops before 3.0 is shown.
Danish: Når pennen indeholder mindre end 3,0 mg, stopper dosistælleren, inden 3,0 bliver vist.
English: In clinical trials, 2.5% of patients treated with liraglutide developed anti-liraglutide antibodies.
Danish: I kliniske studier udviklede 2,5 % af patienterne, der blev behandlet med liraglutid, anti-liraglutidantistoffer.
English: Do not use Saxenda if you are pregnant, think that you might be pregnant or are planning to have a baby.
Danish: Du må ikke bruge Saxenda, hvis du er gravid, har mistanke om, at du er gravid, eller planlægger at blive gravid, da det er ukendt, om Saxenda kan skade dit barn.
English: The background treatment at trial start was either diet and exercise alone, metformin, a sulfonylurea, a glitazone as single agents or any combination hereof.
Danish: Baggrundsbehandlingen ved studiets start var enten diæt og motion alene, metformin, et sulfonylurinstof, et glitazon som monoterapi eller en kombination af disse.
English: The mean clearance following subcutaneous administration of liraglutide is approximately 0.9-1.4 L/h with an elimination half-life of approximately 13 hours.
Danish: Middel-clearance efter subkutan administration af liraglutid er ca. 0,9-1,4 l/time med en halveringstid på ca. 13 timer.
English: Cardiovascular evaluation
Danish: Kardiovaskulær vurdering
English: 5 After your injection • Lead the needle tip into the outer needle cap on a flat surface without touching the needle or the outer needle cap.
Danish: 5 Efter injektionen • Før nålens spids ind i den ydre nålehætte, mens den ligger på en plan overflade, uden at røre ved nålen eller den ydre nålehætte.
English: Mean baseline HbA1c was 8.7 and had improved after 3 years by 1.2 % in patients assigned to liraglutide and by 0.8 % in patients assigned to placebo.
Danish: Baseline HbA1c var gennemsnitligt 8,7 og blev efter 3 år forbedret med 1,2% hos patienter tildelt liraglutid og med 0,8% hos patienter tildelt placebo.
English: Hypoglycaemia* Dehydration
Danish: Hypoglykæmi* Dehydrering
English: Increased amylase *Hypoglycaemia (based on self-reported symptoms by patients and not confirmed by blood glucose measurements) reported in patients without type 2 diabetes mellitus treated with Saxenda in combination with diet and exercise.
Danish: Forhøjet amylase *Hypoglykæmi (baseret på symptomer rapporteret af patienterne selv og ikke bekræftet af blodglucosemålinger) rapporteret hos patienter uden type 2-diabetes mellitus, der blev behandlet med Saxenda kombineret med diæt og motion.
English: Dosing with liraglutide during mid-gestation caused a reduction in maternal weight and foetal growth with equivocal effects on ribs in rats and skeletal variation in the rabbit.
Danish: Administration af liraglutid midt i graviditeten forårsagede reduktion af moderens vægt og fostervækst med usikre virkninger på ribben hos rotter og skeletvariationer hos kaniner.
English: tmax was delayed by 1.5 h with liraglutide for both compounds.
Danish: tmaks blev forsinket med 1,5 time med liraglutid for begge forbindelser.
English: At week 160, while on treatment, 3% treated with Saxenda and 11% treated with placebo were diagnosed with type 2 diabetes mellitus.
Danish: Ved behandlingsuge 160 blev 3% behandlet med Saxenda og 11% behandlet med placebo diagnosticeret med type 2-diabetes mellitus.
English: The solution should not be used if it does not appear clear and colourless or almost colourless.
Danish: Opløsningen må ikke anvendes, hvis den ikke er klar og farveløs eller næsten farveløs.
English: The effect on rate of gastric emptying was equivalent between liraglutide 1.8 mg and 3.0 mg, (paracetamol AUC0-300 min).
Danish: Virkningen på hastigheden af ventrikeltømningen var den samme for liraglutid 1,8 mg og 3,0 mg (paracetamol AUC0-300 min).
English: Based on the exposure response data, no dose adjustment is necessary based on gender.
Danish: Ifølge eksponeringsresponsdata er dosisjustering på grund af køn ikke nødvendig.
English: Always use the dose counter and the dose pointer to see how many mg you have selected before injecting this medicine.
Danish: Brug altid dosistælleren og dosismarkøren til at se, hvor mange mg du har valgt, før du injicerer medicinen.
English: Table 1 Dose escalation schedule Dose
Danish: Tabel 1 Plan for dosisstigning
English: For patients who have achieved a weight loss of <5% after 12 weeks on treatment dose of liraglutide, the proportion of patients not reaching a weight loss of ≥10% after 1 year is 93.4%.
Danish: Hos patienter, der har opnået et vægttab på <5% efter 12 uger med liraglutid-behandlingsdosis, er andelen af patienter, der ikke opnår et vægttab på ≥10% efter 1 år,
English: • If the needle is removed earlier, you may see a stream of solution coming from the needle tip.
Danish: • Hvis nålen fjernes tidligere, vil du måske se opløsning sive ud fra nålens spids.
English: Liraglutide significantly reduced the rate of major adverse cardiovascular events (primary endpoint events, MACE) vs. placebo (3.41 vs. 3.90 per 100 patient years of observation in the liraglutide and placebo groups, respectively) with a risk reduction of 13%, HR 0.87, [0.78, 0.97] [95% CI]) (p=0.005) (see figure 4).
Danish: Liraglutid reducerede signifikant raten af større kardiovaskulære hændelser (primære endepunktshændelser, MACE) versus placebo (3,41 versus 3,90 per 100 patientår fra observationerne i henholdsvis liraglutid- og placebogrupperne) med en risikoreduktion på 13%, HR 0,87, [0,78; 0,97] [95% CI]) (p=0,005) (se figur 4).
English: Treatment with liraglutide significantly improved glycaemic parameters across sub-populations with normoglycaemia, pre-diabetes and type 2 diabetes mellitus.
Danish: Behandling med liraglutid forbedrer glykæmiske parametre signifikant på tværs af delpopulationer med normoglykæmi, prædiabetes og type 2-diabetes mellitus.
English: Talk to your doctor, pharmacist or nurse if you have any questions or concerns.
Danish: Tal med lægen, apotekspersonalet eller sygeplejersken, hvis du har spørgsmål eller er bekymret.
English: • you are taking medicines for diabetes called ‘sulfonylurea' (such as glimepiride or glibenclamide) or if you are taking insulin - you may get low blood sugar (hypoglycaemia)
Danish: • du tager diabetesmedicin, der kaldes ‘sulfonylurinstof' (såsom glimepirid eller glibenclamid) eller hvis du tager insulin - du kan få for lavt blodsukker (hypoglykæmi), hvis du bruger disse lægemidler sammen med Saxenda.
English: In trial 4, more patients maintained the weight loss achieved prior to treatment initiation with liraglutide than with placebo (81.4% and 48.9%, respectively).
Danish: I studie 4 opretholdt flere patienter det vægttab, der var opnået inden behandlingsstart, med liraglutid end med placebo (henholdsvis 81,4% og 48,9%).
English: If there is less than 12 hours to the next dose, the patient should not take the missed dose and resume the once-daily regimen with the next scheduled dose.
Danish: Hvis der er mindre end 12 timer til næste dosis, skal patienten ikke tage den glemte dosis, men genoptage doseringsprogrammet med én daglig dosis på næste planlagte doseringstidspunkt.
English: Saxenda contains less than 1 mmol sodium (23 mg) per dose, therefore the medicinal product is essentially ‘sodium-free'.
Danish: Saxenda indeholder mindre end 1 mmol natrium (23 mg) pr. dosis, og lægemidlet er derfor stort set ‘natriumfrit'.
English: If so, the full dose will not be delivered.
Danish: I så fald har du ikke fået den fulde dosis.
English: With continued treatment with liraglutide, 86.2% of these early responders are predicted to achieve a weight loss of ≥5% and 51% are predicted to achieve a weight loss of ≥10%
Danish: Ved fortsat behandling med liraglutid antages det, at 86,2% af dem, der tidligt opnår en effekt vil opnå et vægttab på ≥5%, og 51 % antages at opnå et vægttab på ≥10% efter 1 års behandling.
English: The average liraglutide steady state concentration (AUCτ/24) reached approximately 31 nmol/L in obese (BMI 30-40 kg/m2) patients following administration of 3 mg liraglutide.
Danish: Den gennemsnitlige steady state-koncentration (AUCτ/24) af liraglutid var ca. 31 nmol/l hos adipøse (BMI 30-40 kg/m2) patienter efter administration af 3 mg liraglutid.
English: Do not use the pen without proper training from your doctor or nurse.
Danish: Tag ikke pennen i brug, før du har fået grundig undervisning af lægen eller sygeplejersken.
English: Liraglutide exposure was lowered by 33%, 14%, 27% and 26%, respectively, in patients with mild (creatinine clearance, CrCl 50-80 ml/min), moderate (CrCl 30-50 ml/min) and severe (CrCl <30 ml/min) renal impairment and in end-stage renal disease requiring dialysis.
Danish: Eksponeringen af liraglutid var reduceret med henholdsvis 33%, 14%, 27% og 26% hos patienter med let (kreatinin-clearance (CrCl) 50-80 ml/min), moderat (CrCl 30-50 ml/min) og svært (CrCl < 30 ml/min) nedsat nyrefunktion samt dialysekrævende terminal nyreinsufficiens.
English: The patient should be advised to discard the injection needle after each injection and store the pen without an injection needle attached.
Danish: Patienten skal informeres om at bortskaffe nålen efter hver injektion og opbevare pennen uden påsat nål.
English: • The pen scale shows you approximately how much solution is left in your pen.
Danish: • Penskalaen viser, hvor meget opløsning der cirka er tilbage i pennen.
English: Liraglutide exposure was decreased by 13-23% in patients with mild to moderate hepatic impairment compared to healthy subjects.
Danish: Eksponeringen af liraglutid var reduceret med 13-23% hos patienter med let til moderat nedsat leverfunktion sammenlignet med raske forsøgspersoner.
English: The hazard ratio and 95% CI is 0.33 [0.12; 0.90] for liraglutide versus placebo.
Danish: Den relative risiko og 95 % CI er 0,33 [0,12; 0,90] for liraglutid i forhold til placebo.
English: The glucose-lowering effect is more pronounced in patients with pre-diabetes and diabetes compared to patients with normoglycaemia.
Danish: Den glucosesænkende virkning er mere udtalt hos patienter med prædiabetes og diabetes end hos normoglykæmiske patienter.
English: Non-clinical studies have shown a treatment-related reduction of neonatal growth in suckling rat pups (see section 5.3).
Danish: Ikke-kliniske studier har påvist behandlingsrelateret nedsat neonatal vækst hos diende rotteunger (se pkt.
English: Patients with mild or moderate renal impairment (creatinine clearance ≥30 ml/min) may experience more gastrointestinal effects when treated with Saxenda.
Danish: Patienter med let eller moderat nedsat nyrefunktion (kreatinin-clearance på ≥30 ml/min) kan hyppigere opleve gastrointestinale bivirkninger, når de behandles med Saxenda.
English: You can keep the pen for 1 month when stored at a temperature below 30°C or in a refrigerator (2°C to 8°C).
Danish: Du kan bruge pennen i 1 måned, hvis den opbevares ved temperaturer under 30°C eller i et køleskab (2°C til 8°C).
English: • Severe and persistent pain in the abdomen (stomach area) which might reach through to your back, as well as nausea and vomiting, as it could be a sign of an inflamed pancreas
Danish: • Svære og vedvarende mavesmerter, som eventuelt kan stråle ud til ryggen, samt kvalme og opkastning, da dette kan være et tegn på betændelse i bugspytkirtlen (pankreatitis).
English: Always make sure that a drop appears at the needle tip before you use a new pen for the first time.
Danish: Kontrollér altid, at der kommer en dråbe til syne på nålens spids, før du tager en ny pen i brug.
English: Ethnic origin had no clinically relevant effect on the pharmacokinetics of liraglutide based on the results of population pharmacokinetic analysis which included overweight and obese patients of White, Black, Asian and Hispanic/non-Hispanic groups.
Danish: Etnisk oprindelse havde ingen klinisk relevant effekt på farmakokinetikken af liraglutid baseret på resultaterne fra en farmakokinetisk analyse af data for patientgrupper med hvide, sorte, asiatiske og latinamerikanske/ikke-latinamerikanske overvægtige og adipøse patienter.
English: Liraglutide is an acylated human glucagon-like peptide-1 (GLP-1) analogue with 97% amino acid sequence homology to endogenous human GLP-1.
Danish: Liraglutid er en acyleret human glukagon-lignende peptid-1 (GLP-1)-analog med 97% aminosyresekvenshomologi til humant endogent GLP-1.
English: Superior weight loss was achieved with liraglutide compared to placebo in obese/overweight patients in all groups studied.
Danish: Der blev opnået et større vægttab med liraglutid sammenlignet med placebo hos adipøse/overvægtige patienter i alle undersøgte grupper.
English: Diastolic blood pressure, mmHg
Danish: Diastolisk blodtryk, mmHg
English: • Take a new needle and tear off the paper tab.
Danish: • Tag en ny nål og riv papirforseglingen af.
English: The starting dose is 0.6 mg once daily.
Danish: Startdosis er 0,6 mg én gang dagligt.
English: Liraglutide did not change the overall exposure of paracetamol following a single dose of 1,000 mg. Paracetamol Cmax was decreased by 31% and median tmax was delayed up to 15 min. No dose adjustment for concomitant use of paracetamol is required.
Danish: Liraglutid ændrede ikke den overordnede eksponering af paracetamol efter én enkelt dosis på 1.000 mg. Paracetamols Cmaks blev reduceret med 31 %, og medianværdien for tmaks blev forsinket med op til 15 min. Dosisjustering ved samtidig brug af paracetamol er ikke nødvendig.
English: In clinical trials in type 2 diabetes, thyroid adverse events, such as goitre, have been reported in particular in patients with pre-existing thyroid disease.
Danish: I kliniske studier med type 2-diabetes er der rapporteret om thyroidea-relaterede bivirkninger, såsom struma, særligt hos patienter med allerede eksisterende thyroideasygdom.
English: If you stop using Saxenda
Danish: Hvis du holder op med at bruge Saxenda
English: The estimated time to onset of type 2 diabetes mellitus for patients treated with liraglutide 3.0 mg was 2.7 times longer (with a 95% confidence interval of [1.9, 3.9]), and the hazard ratio for risk of developing type 2 diabetes mellitus was 0.2 for liraglutide versus placebo.
Danish: Den estimerede tid indtil diagnosticering af type 2-diabetes mellitus hos patienter behandlet med liraglutid 3,0 mg var 2,7 gange længere (med et 95% konfidensinterval på [1,9; 3,9]), og risikoforholdet for at udvikle type 2-diabetes mellitus var 0,2 for liraglutid versus placebo.
English: In particular, tell your doctor, pharmacist or nurse if:
Danish: Det er især vigtigt, at du fortæller det til lægen, apotekspersonalet eller sygeplejersken, hvis:
English: Liraglutide regulates appetite by increasing feelings of fullness and satiety, while lowering feelings of hunger and prospective food consumption, thereby leading to reduced food intake.
Danish: Liraglutid regulerer appetitten ved at øge mæthedsfornemmelsen, samtidig med at følelsen af sult og behovet for fødeindtagelse sænkes, hvilket fører til et reduceret fødeindtag.
English: In trial 2, 50.4% achieved ≥5% weight loss after 12 weeks.
Danish: opnåede 50,4% et vægttab på ≥5% efter 12 uger.
English: Animal studies have shown that the transfer of liraglutide and metabolites of close structural relationship into milk is low.
Danish: Dyreforsøg har påvist, at liraglutid og metabolitter, der er nært strukturelt beslægtede, kun i ringe omfang udskilles i mælk.
English: After first use of the pen, store below 30°C or in a refrigerator Keep the pen cap on in order to protect from light
Danish: Efter første anvendelse skal pennen opbevares ved temperaturer under 30°C eller i køleskab Opbevar pennen med hætten påsat for at beskytte mod lys
English: • The best places to inject are the front of your waist (abdomen), the front of your thighs or your upper arm.
Danish: • De bedste steder til injektion er foran i maveskindet, foran i låret eller i overarmen.
English: Blood glucose self-monitoring is necessary to adjust the dose of insulin or insulin-secretagogues (see section
Danish: Selvmonitorering af blodglucose er nødvendig for at justere dosen af insulin eller β-cellestimulerende midler (se pkt.
English: Figure 1 Change from baseline in body weight (%) by time in trial 1 (0-56 weeks)
Danish: Figur 1 Ændring i legemsvægt fra baseline (%) over tid i studie 1 (0-56 uger)
English: • Problems affecting the stomach and intestines, such as indigestion (dyspepsia), inflammation in the lining of the stomach (gastritis), stomach discomfort, upper stomach pain, heartburn, feeling bloated, wind (flatulence), belching and dry mouth
Danish: • Problemer, der vedrører maven og tarmene såsom fordøjelsesproblemer (dyspepsi), betændt slimhinde i maven (gastritis), mavegener, smerter øverst i maven, halsbrand, oppustethed, luft i maven (flatulens), tendens til at bøvse og mundtørhed
English: The small delay of gastric emptying with liraglutide may influence absorption of concomitantly administered oral medicinal products.
Danish: Den lille forsinkelse af ventrikeltømningen, som liraglutid forårsager, kan påvirke absorptionen af samtidigt indgivne orale lægemidler.
English: More patients with pre-diabetes at baseline had reversed their prediabetes compared to patients treated with placebo (69.2% vs. 32.7%).
Danish: Flere patienter med prædiabetes ved baseline fik vendt udviklingen for deres prædiabetes sammenlignet med patienter, der fik placebo (69,2% i forhold til 32,7%).
English: If there is still no drop, change the needle and repeat step 2 ‘Check the flow' once more.
Danish: Hvis der stadig ikke kommer en dråbe til syne, skiftes nålen, og trin 2 ‘Klargøring' gentages en gang mere.
English: FPG=fasting plasma glucose.
Danish: FPG=fasteplasmaglucose.
English: This medicine contains less than 1 mmol sodium (23 mg) per dose, that it is to say essentially ‘sodium-free'.
Danish: Dette lægemiddel indeholder mindre end 1 mmol natrium (23 mg) per dosis, hvilket betyder, at lægemidlet stort set er ‘natriumfrit'.
English: Liraglutide did not change the overall exposure of atorvastatin following single dose administration of atorvastatin 40 mg.
Danish: Liraglutid ændrede ikke den overordnede eksponering af atorvastatin efter administration af én dosis på 40 mg atorvastatin.