FrancophonIA/ELRC3.0 huggingface dataset:
English: Baseline regimen = ritonavir or cobicistat-boosted PI (specifically atazanavir, darunavir, or lopinavir), or cobicistat-boosted elvitegravir, or NNRTI (specifically efavirenz, nevirapine, or rilpivirine), each administered with two NRTIs.
Croatian: Početni režim = inhibitor proteaze pojačan ritonavirom ili kobicistatom (posebno atazanavir, darunavir ili lopinavir), ili elvitegravir pojačan kobicistatom, ili NNRTI (posebno efavirenz, nevirapin ili rilpivirin), svaki primijenjen s dva NRTI-ja.
English: The antiviral activity of lamivudine against HIV-1 was assessed in a number of cell lines including monocytes and peripheral blood mononuclear cells (PBMCs) using standard susceptibility assays.
Croatian: Antivirusna aktivnost lamivudina protiv HIV-1 ocjenjivala se u nizu staničnih kultura, uključujući monocite i mononuklearne stanice iz periferne krvi, korištenjem standardnih testova osjetljivosti.
English: Cmax and AUC values were 0.30 ± 0.09 micrograms per mL and 2.29 ± 0.69 µg•hr per mL, respectively.
Croatian: Cmax je iznosio 0,30 ± 0,09 μg/ml, a AUC 2,29 ± 0,69 µg•h/ml.
English: The antiviral activity of tenofovir against laboratory and clinical isolates of HIV-1 was assessed in T lymphoblastoid cell lines, primary monocyte/macrophage cells and peripheral blood lymphocytes.
Croatian: Antivirusna aktivnost tenofovirdizoproksila protiv laboratorijskih i kliničkih izolata HIV-1 ocjenjivala se u T-limfoblastoidnim staničnim linijama, prvenstveno monocitima/makrofagima i limfocitima iz periferne krvi.
English: If you forget to take Delstrigo
Croatian: Ako ste zaboravili uzeti Delstrigo
English: Lamivudine and tenofovir disoproxil are primarily excreted by the kidney.
Croatian: Lamivudin i tenofovirdizoproksil primarno se izlučuju kroz bubrege.
English: Based on the lamivudine data, Delstrigo is not recommended for patients with CrCl of < 50 mL/min.
Croatian: S obzirom na podatke o lamivudinu, ne preporučuje se primjena lijeka Delstrigo u bolesnika kojima je CrCl < 50 ml/min.
English: Reproductive toxicity studies in rats and rabbits showed no effects on mating, fertility, pregnancy or foetal parameters.
Croatian: Ispitivanja reproduktivne toksičnosti u štakora i kunića nisu pokazala učinke na parenje, plodnost, skotnost ni fetalne parametre.
English: No significant cross-resistance has been demonstrated between doravirine-resistant HIV-1 variants and lamivudine/emtricitabine or tenofovir or between lamivudine- or tenofovir-resistant variants and doravirine.
Croatian: Nije utvrđena značajna križna rezistencija između varijanti HIV-1 rezistentnih na doravirin i lamivudina/emtricitabina ili tenofovira ni između varijanti rezistentnih na lamivudin ili tenofovir i doravirina.
English: • decreased number of white blood cells in your blood (neutropenia)
Croatian: • smanjen broj bijelih krvnih stanica u krvi (neutropenija)
English: Therefore, caution is advised when doravirine/lamivudine/tenofovir disoproxil is administered to patients with severe hepatic impairment (see section 5.2).
Croatian: Stoga se preporučuje oprez kada se doravirin/lamivudin/tenofovirdizoproksil primjenjuje u bolesnika s teškim oštećenjem funkcije jetre (vidjeti dio 5.2).
English: Persistent or worsening bone pain, pain in extremities, fractures, and/or muscular pain or weakness may be manifestations of proximal renal tubulopathy and should prompt an evaluation of renal function in at risk patients.
Croatian: Bol u kostima koja perzistira ili se pogoršava, bol u ekstremitetima, prijelomi i/ili bol u mišićima ili slabost mišića mogu biti manifestacije proksimalne bubrežne tubulopatije i trebale bi potaknuti ocjenu funkcije bubrega u rizičnih bolesnika.
English: Tenofovir disoproxil requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate.
Croatian: Tenofovirdizoproksilu je najprije potrebna hidroliza diestera da bi se pretvorio u tenofovir, a zatim fosforilacija djelovanjem staničnih enzima da bi nastao tenofovirdifosfat.
English: Subjects must have been virologically suppressed (HIV-1 RNA < 40 copies/mL) on their baseline regimen for at least 6 months prior to trial entry, with no history of virologic failure, and a documented absence of RT substitutions conferring resistance to doravirine, lamivudine and tenofovir (see section, Resistance).
Croatian: Virološka supresija (HIV-1 RNK < 40 kopija/ml) morala je biti postignuta početnim režimom u ispitanika tijekom najmanje 6 mjeseci prije ulaska u ispitivanje, pri čemu u anamnezi nije zabilježen izostanak virološkog odgovora, uz dokumentiranu odsutnost supstitucija u reverznoj transkriptazi koje donose rezistenciju na doravirin, lamivudin i tenofovir (vidjeti dio Rezistencija).
English: Each carton contains a high density polyethylene (HDPE) bottle with a polypropylene child-resistant closure with silica gel desiccants.
Croatian: Jedno pakiranje sadrži bocu od polietilena visoke gustoće (HDPE) zatvorenu polipropilenskim zatvaračem sigurnim za djecu koja sadrži silika-gel kao sredstvo za sušenje.
English: • thioridazine (a medicine to treat psychiatric conditions such as schizophrenia)
Croatian: • tioridazin (lijek za liječenje psihijatrijskih bolesti, kao što je shizofrenija)
English: In patients at risk of renal dysfunction, including patients who have previously experienced renal events while receiving adefovir dipivoxil, it is recommended that estimated CrCl, serum phosphorus, urine glucose, and urine protein be assessed prior to initiation of Delstrigo and more frequent renal function monitoring should be assessed as appropriate per the patient's medical condition during Delstrigo therapy.
Croatian: U bolesnika u kojih postoji rizik od poremećaja funkcije bubrega, uključujući bolesnike koji su prethodno imali bubrežne događaje tijekom liječenja adefovirdipivoksilom, preporučuje se prije uvođenja lijeka Delstrigo ocijeniti vrijednosti procijenjenog CrCl, vrijednosti fosfora u serumu, vrijednosti glukoze u mokraći i vrijednosti proteina u mokraći te po potrebi češće kontrolirati funkciju bubrega tijekom liječenja lijekom Delstrigo, u skladu s bolesnikovim medicinskim stanjem.
English: The pharmacokinetics of tenofovir following a 245 mg dose of tenofovir disoproxil have been studied in healthy subjects with moderate to severe hepatic impairment.
Croatian: Farmakokinetika tenofovira nakon doze tenofovirdizoproksila od 245 mg ispitivala se u zdravih ispitanika s umjerenim do teškim oštećenjem funkcije jetre.
English: • cough, nasal symptoms
Croatian: • kašalj, nosni simptomi
English: Findings in the rat and monkey studies indicated that there was a substance related decrease in intestinal absorption of phosphate with potential secondary reduction in BMD.
Croatian: Nalazi dobiveni u ispitivanjima na štakorima i majmunima ukazali su na smanjenje apsorpcije fosfata u crijevima povezano s primjenom djelatne tvari, uz potencijalno sekundarno smanjenje BMD-a.
English: Rare acute kidney injury, renal disorder, calculus urinary, nephrolithiasis, acute renal failure*, renal failure*, acute tubular necrosis*, nephritis (including acute interstitial)*, nephrogenic diabetes insipidus*
Croatian: rijetko akutna ozljeda bubrega, poremećaj bubrega, mokraćni kamenac, nefrolitijaza, akutno zatajenje bubrega*, zatajenje bubrega*, akutna tubularna nekroza*, nefritis (uključujući akutni intersticijski)*, nefrogeni dijabetes insipidus*
English: Single dose lamivudine oral solution 300 mg lamivudine
Croatian: Jednokratna doza oralne otopine lamivudina od 300 mg lamivudin
English: When possible, avoid chronic co-administration of doravirine/lamivudine/tenofovir disoproxil with medicinal products containing sorbitol or other osmotic acting polyalcohols (e.g., xylitol, mannitol, lactitol, maltitol).
Croatian: Kada je to moguće, potrebno je izbjegavati dugoročnu primjenu doravirina/lamivudina/ tenofovirdizoproksila s lijekovima koji sadrže sorbitol ili druge polialkohole s osmotskim djelovanjem (npr. ksilitol, manitol, laktitol, maltitol).
English: No dose adjustment of Delstrigo is required in adults with estimated creatinine clearance (CrCl) ≥ 50 mL/min.
Croatian: Nije potrebno prilagođavati dozu lijeka Delstrigo u odraslih osoba s procijenjenim klirensom kreatinina (CrCl) ≥ 50 ml/min.
English: • nafcillin (a medicine to treat some bacterial infections)
Croatian: • nafcilin (lijek za liječenje nekih bakterijskih infekcija)
English: Findings in repeat-dose toxicity studies in rats, dogs and monkeys at exposure levels greater than or equal to clinical exposure levels and with possible relevance to clinical use included kidney and bone changes and a decrease in serum phosphate concentration.
Croatian: Rezultati ispitivanja toksičnosti ponovljenih doza provedenih na štakorima, psima i majmunima pri razinama izloženosti većima ili jednakima kliničkim razinama izloženosti koji bi mogli biti značajni za kliničku primjenu uključivali su promjene na bubrezima i kostima te sniženje koncentracije fosfata u serumu.
English: Delstrigo is indicated for the treatment of adults infected with HIV-1 without past or present evidence of resistance to the NNRTI class, lamivudine, or tenofovir (see sections 4.4 and 5.1).
Croatian: Delstrigo je indiciran za liječenje odraslih osoba s infekcijom virusom humane imunodeficijencije tipa 1 (HIV-1) bez prethodnih ili trenutačnih dokaza rezistencije na lijekove iz skupine nenukleozidnih inhibitora reverzne transkriptaze (engl. non-nucleoside reverse transcriptase inhibitors, NNRTI), lamivudin ili tenofovir (vidjeti dijelove 4.4 i 5.1).
English: Oral carcinogenicity studies in rats and mice only revealed a low incidence of duodenal tumours at an extremely high-dose in mice.
Croatian: Ispitivanja kancerogenosti nakon peroralne primjene provedena na štakorima i miševima pokazala su samo nisku incidenciju tumora dvanaesnika pri ekstremno visokim dozama u miševa.
English: Compared with subjects with normal renal function, the mean (% CV) tenofovir exposure increased from 2,185 (12 %) ng·h/mL in subjects with CrCl > 80 mL/min to respectively 3,064 (30 %) ng·h/mL, 6,009 (42 %) ng·h/mL and 15,985 (45 %) ng·h/mL in subjects with mild, moderate, and severe renal impairment.
Croatian: U usporedbi s ispitanicima s normalnom funkcijom bubrega, srednja vrijednost (% CV) izloženosti tenofoviru porasla je s 2185 (12%) ng·h/ml u ispitanika kojima je CrCl iznosio > 80 ml/min na 3064 (30%) ng·h/ml, 6009 (42%) ng·h/ml i 15 985 (45%) ng·h/ml u ispitanika s blagim, umjerenim odnosno teškim oštećenjem funkcije bubrega.
English: Discontinued study due to AE or Death
Croatian: Prekid ispitivanja zbog štetnog događaja ili smrti
English: GM: Geometric mean, %CV: Geometric coefficient of variation
Croatian: Geometric coefficient of variation): geometrijski koeficijent varijacije
English: Co-administration of doravirine/lamivudine/tenofovir disproxil and medicinal products that are inhibitors of CYP3A may result in increased plasma concentrations of doravirine.
Croatian: Istodobna primjena doravirina/lamivudina/tenofovirdizoproksila i lijekova koji su inhibitori CYP3A može povisiti koncentracije doravirina u plazmi.
English: In the DRIVE-SHIFT trial, an immediate switch to Delstrigo was demonstrated to be non-inferior at Week 48 compared to continuation of the baseline regimen at Week 24 as assessed by the proportion of subjects with HIV-1 RNA < 40 copies/mL.
Croatian: U ispitivanju DRIVE-SHIFT, prelazak na Delstrigo bez odgode pokazao se neinferiornim u 48. tjednu u usporedbi s nastavkom početnog režima u 24. tjednu, što je procijenjeno prema omjeru ispitanika s HIV-1 RNK < 40 kopija/ml.
English: Doravirine is primarily metabolised by CYP3A, and medicinal products that induce or inhibit CYP3A are expected to affect the clearance of doravirine (see section 5.2).
Croatian: Budući da se doravirin primarno metabolizira putem CYP3A, očekuje se da će lijekovi koji induciraju ili inhibiraju CYP3A utjecati na klirens doravirina (vidjeti dio 5.2).
English: • feeling weak, general feeling of being unwell
Croatian: • slabost, opće loše osjećanje
English: Other substitutions yielded a fold change of 5-10 (G190S (5.7); K103N/P225H (7.9), V108I/Y181C (6.9), Y181V (5.1)).
Croatian: Uz ostale supstitucije zabilježena je promjena 5 - 10 puta (G190S [5,7 puta], K103N/P225H [7,9 puta], V108I/Y181C [6,9 puta], Y181V [5,1 put]).
English: Lamivudine was mutagenic in an L5178Y mouse lymphoma assay and clastogenic in a cytogenetic assay using cultured human lymphocytes.
Croatian: Lamivudin je bio mutagen u testu na stanicama mišjeg limfoma L5178Y i klastogen u citogenetskom testu na kulturi humanih limfocita.
English: The clinically relevant effects noted were a reduction in red blood cell count and neutropenia.
Croatian: Opaženi klinički značajni učinci bili su smanjenje broja eritrocita i neutropenija.
English: • ledipasvir/sofosbuvir (medicines used to treat hepatitis C infection)
Croatian: • ledipasvir/sofosbuvir (lijekovi koji se koriste za liječenje infekcije virusom hepatitisa C)
English: Metabolism and nutrition disorders Uncommon hypophosphataemia, hypokalaemia*
Croatian: Poremećaji metabolizma i prehrane manje često hipofosfatemija, hipokalijemija*
English: • feeling of incomplete defecation
Croatian: • osjećaj nepotpunog pražnjenja crijeva
English: Because a negligible amount of lamivudine was removed via (4-hour) haemodialysis, continuous ambulatory peritoneal dialysis, and automated peritoneal dialysis, it is not known if continuous haemodialysis would provide clinical benefit in a lamivudine overdose event.
Croatian: Budući da je (4-satnom) hemodijalizom, kontinuiranom ambulantnom peritonejskom dijalizom i automatiziranom peritonejskom dijalizom uklonjena zanemariva količina lamivudina, nije poznato bi li kontinuirana hemodijaliza bila klinički korisna u slučaju predoziranja lamivudinom.
English: Tenofovir displayed antiviral activity in cell culture against HIV-1 clades A, B, C, D, E, F, G, and O (EC50 values ranged from 0.5-2.2 microM).
Croatian: Tenofovir je u staničnoj kulturi pokazao antivirusnu aktivnost protiv virusa HIV-1 podtipa A, B, C, D, E, F, G i O (vrijednosti EC50 kretale su se u rasponu od 0,5 do 2,2 µM).
English: Pharmacokinetic parameters of tenofovir were determined following administration of a single dose of tenofovir disoproxil 245 mg to 40 non-HIV infected adult subjects with varying degrees of renal impairment defined according to baseline CrCl (normal renal function when CrCl > 80 mL/min; mild with CrCl = 50-79 mL/min; moderate with CrCl = 30-49 mL/min and severe with CrCl = 10-29 mL/min).
Croatian: Farmakokinetički parametri tenofovira određivali su se nakon primjene jednokratne doze tenofovirdizoproksila od 245 mg u 40 odraslih ispitanika bez HIV infekcije koji su imali različite stupnjeve oštećenja funkcije bubrega definiranog prema početnom klirensu kreatinina (normalna funkcija bubrega: CrCl > 80 ml/min; blago oštećenje: CrCl=50 - 79 ml/min; umjereno oštećenje: CrCl=30 - 49 ml/min; teško oštećenje: CrCl=10 - 29 ml/min).
English: • 1 bottle with 30 film-coated tablets
Croatian: • 1 boca s 30 filmom obloženih tableta
English: DOR + NRTIs*
Croatian: DOR + NRTI-ji*
English: Subsequently F227(L/C/V) or L234I emerged in addition to V106 substitutions (double mutants yielding a fold change of > 100).
Croatian: Nakon toga se uz supstitucije V106 javila i mutacija F227(L/C/V) ili L234I (dvostruke mutacije koje su dovele do promjene > 100 puta u odnosu na početnu vrijednost).
English: • feeling sick (nausea), diarrhoea, stomach pain, vomiting, wind (flatulence)
Croatian: • mučnina, proljev, bol u trbuhu, povraćanje, vjetrovi (flatulencija)
English: Bone problems include bone pain, and bone softening or thinning (which may lead to fractures).
Croatian: Tegobe s kostima uključuju bol u kostima te omekšavanje ili stanjivanje kosti (koje može dovesti do prijeloma).
English: • This medicinal product does not require any special temperature storage conditions.
Croatian: • Lijek ne zahtijeva čuvanje na određenoj temperaturi.
English: • St. John's wort (Hypericum perforatum)
Croatian: • gospinu travu (Hypericum perforatum)
English: Doravirine was not genotoxic in a battery of in vitro or in vivo assays.
Croatian: Doravirin Doravirin nije bio genotoksičan u nizu testova in vitro ili in vivo.
English: Co-administration with medicinal products that are strong cytochrome P450 CYP3A enzyme inducers is contraindicated as significant decreases in doravirine plasma concentrations are expected to occur, which may decrease the effectiveness of Delstrigo (see sections 4.4 and 4.5).
Croatian: Istodobna primjena s lijekovima koji su snažni induktori enzima citokroma P450 CYP3A kontraindicirana je jer se očekuju značajna sniženja koncentracija doravirina u plazmi, koja mogu smanjiti učinkovitost lijeka Delstrigo (vidjeti dijelove 4.4 i 4.5).
English: If a patient misses a dose of Delstrigo by more than 12 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time.
Croatian: Ako je od propuštene doze prošlo više od 12 sati, bolesnik ne smije uzeti propuštenu dozu, nego treba uzeti sljedeću predviđenu dozu prema uobičajenom rasporedu.
English: Delstrigo is a complete regimen taken as a single tablet for the treatment of HIV infection.
Croatian: Delstrigo je cjelovit režim za liječenje HIV infekcije, koji se uzima u obliku jedne tablete.
English: Doravirine-resistant strains were selected in cell culture starting from wild-type HIV-1 of different origins and subtypes, as well as NNRTI-resistant HIV-1.
Croatian: Sojevi rezistentni na doravirin izdvojeni su u staničnoj kulturi, počevši od HIV-1 divljeg tipa različitog podrijetla i podtipova te HIV-1 rezistentnog na NNRTI-je.
English: In DRIVE-FORWARD, 766 subjects were randomised and received at least 1 dose of either doravirine 100 mg or darunavir + ritonavir 800+100 mg once daily, each in combination with emtricitabine/tenofovir disoproxil (FTC/TDF) or abacavir/lamivudine (ABC/3TC) selected by the investigator.
Croatian: U ispitivanju DRIVE-FORWARD, randomizirano je 766 ispitanika koji su primili najmanje 1 dozu doravirina od 100 mg jedanput na dan ili darunavira + ritonavira u dozi od 800+100 mg jedanput na dan, svaki u kombinaciji s emtricitabinom/tenofovirdizoproksilom (FTC/TDF) ili abakavirom/lamivudinom (ABC/3TC), prema izboru ispitivača.
English: Tenofovir Cmax decreased by 12 % and AUC increased by 27 % with a high fat meal.
Croatian: Cmax tenofovira se uz obrok s visokim udjelom masnoća smanjio za 12%, dok se AUC povećao za 27%.
English: HIV-1 isolates with the K65R substitution also showed reduced susceptibility to emtricitabine and lamivudine.
Croatian: Izolati HIV-1 sa supstitucijom K65R pokazali su i smanjenu osjetljivost na emtricitabin te lamivudin.
English: • sirolimus (a medicine used to control your body's immune response after a transplant)
Croatian: • sirolimus (lijek koji se koristi za kontroliranje odgovora imunološkog sustava nakon presađivanja)
English: Film-coated tablets 30 film-coated tablets 90 (3 bottles of 30) film-coated tablets
Croatian: Filmom obložene tablete 30 filmom obloženih tableta 90 (3 boce s 30) filmom obloženih tableta
English: How Delstrigo works
Croatian: Kako Delstrigo djeluje
English: • joint pain, breakdown of muscle tissue, muscular weakness
Croatian: • bol u zglobovima, oštećenje mišićnog tkiva, slabost u mišićima
English: At baseline, the median age of subjects was 31 years (range 18-70 years), 85 % were male, 52 % were non-white, 3 % had hepatitis B or C co-infection, 14 % had a history of AIDS, 21 % had HIV-1 RNA > 100,000 copies per mL, and 12 % had CD4
Croatian: Medijan dobi ispitanika na početku ispitivanja iznosio je 31 godinu (raspon: 18 - 70 godina), 85% bili su muškarci, 52% ispitanika nije bilo bijele rase, 3% istodobno je imalo infekciju virusom hepatitisa B ili C, 14% imalo je AIDS u anamnezi, 21% imalo je razinu HIV-1 RNK višu od 100 000 kopija/ml, a 12% ih je imalo broj CD4
English: Expected: ↑ tenofovir
Croatian: Očekivano: ↑ tenofovir
English: The oral bioavailability of tenofovir from tenofovir disoproxil in fasted subjects is approximately 25 %.
Croatian: Bioraspoloživost tenofovira iz tenofovirdizoproksila nakon peroralne primjene iznosi približno 25%.
English: *This adverse reaction was not identified as an adverse reaction associated with doravirine from the Phase 3 clinical studies (DRIVE-FORWARD, DRIVE-AHEAD, DRIVE-SHIFT), but is included in this table as an adverse reaction based on the Summary of Product Characteristics of 3TC and/or TDF.
Croatian: *Ova nuspojava nije utvrđena kao nuspojava povezana s doravirinom u kliničkim ispitivanjima faze 3 (DRIVE-FORWARD, DRIVE-AHEAD, DRIVE-SHIFT), ali je kao nuspojava uključena u ovu tablicu prema sažetku opisa svojstava lijeka za lamivudin (3TC) i/ili tenofovirdizoproksilfumarat (TDF).
English: Patients with moderate or severe renal impairment require a dose interval adjustment of lamivudine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.4 and 5.2).
Croatian: Bolesnicima s umjerenim ili teškim oštećenjem funkcije bubrega potrebna je prilagodba intervala doziranja lamivudina i tenofovirdizoproksila koja se ne može postići kombiniranom tabletom (vidjeti dijelove 4.4 i 5.2).
English: If you take more Delstrigo than you should Do not take more than the recommended dose.
Croatian: Nemojte uzeti više od preporučene doze.
English: In an in vivo mouse micronucleus assay, tenofovir disoproxil was negative when administered to male mice.
Croatian: U mišjem mikronukleusnom testu in vivo tenofovirdizoproksil je bio negativan kada je primijenjen mužjacima miševa.
English: Delstrigo should be discontinued if estimated CrCl declines below 50 mL per minute as dose interval adjustment required for lamivudine and tenofovir disoproxil cannot be achieved with the fixed dose combination tablet (see section 4.2).
Croatian: Primjenu lijeka Delstrigo treba prekinuti ako procijenjeni CrCl padne ispod 50 ml/min jer se potrebna prilagodba intervala doziranja lamivudina i tenofovirdizoproksila ne može postići tabletom s fiksnom kombinacijom doza (vidjeti dio 4.2).
English: Consistent results were seen for the comparison at Study Week 24 in each treatment group.
Croatian: Rezultati liječenja prikazani su u Tablici 5. Prilikom usporedbe u 24. tjednu ispitivanja, primijećeni su dosljedni rezultati u obje liječene skupine.
English: Lamivudine was not mutagenic in a microbial mutagenicity assay, in an in vitro cell transformation assay, in a rat micronucleus test, in a rat bone marrow cytogenetic assay, and in an assay for unscheduled DNA synthesis in rat liver.
Croatian: Lamivudin nije bio mutagen u testu mikrobne mutagenosti, testu stanične transformacije in vitro, mikronukleusnom testu na štakorima, citogenetskom testu na koštanoj srži štakora, kao ni u testu neplanirane sinteze DNK u jetri štakora.
English: No dose adjustment of doravirine/lamivudine/tenofovir disoproxil is required in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment.
Croatian: Nije potrebno prilagođavati dozu doravirina/lamivudina/tenofovirdizoproksila u bolesnika s blagim (Child-Pugh stadij A) ili umjerenim (Child-Pugh stadij B) oštećenjem funkcije jetre.
English: What Delstrigo looks like and contents of the pack Delstrigo is available as a yellow, oval-shaped, film-coated tablet, and is debossed with the corporate logo and 776 on one side and plain on the other side.
Croatian: Delstrigo je žuta, ovalna filmom obložena tableta s utisnutim logotipom proizvođača i oznakom „776“ na jednoj strani i bez oznake na drugoj strani.
English: Lamivudine-resistant variants of HIV-1 have been selected in cell culture and in subjects treated with lamivudine.
Croatian: Varijante HIV-1 rezistentne na lamivudin izdvojene su u staničnoj kulturi i u ispitanika liječenih lamivudinom.
English: Lamivudine-resistant HIV-1 mutants were also cross resistant to didanosine (ddI).
Croatian: Mutirani oblici HIV-1 rezistentni na lamivudin također su pokazali križnu rezistenciju i na didanozin.
English: 2031 BN Haarlem NETHERLANDS
Croatian: 2031 BN Haarlem NIZOZEMSKA