FrancophonIA/ELRC3.0 huggingface dataset:
English: (3) More commonly reported when tadalafil is given to patients who are already taking antihypertensive medicinal products.
Croatian: (3) Češće prijavljeno kad se tadalafil primjenjuje u bolesnika koji već uzimaju antihipertenzive.
English: In such circumstances, nitrates should only be administered under close medical supervision with appropriate haemodynamic monitoring.
Croatian: U takvim okolnostima nitrate treba primijeniti isključivo pod strogim nadzorom liječnika i uz odgovarajuće hemodinamičko praćenje.
English: The major circulating metabolite is the methylcatechol glucuronide.
Croatian: Glavni metabolit u cirkulaciji je metilkatehol-glukuronid.
English: Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces (approximately 61 % of the dose) and to a lesser extent in the urine (approximately 36 % of the dose).
Croatian: Tadalafil se pretežno izlučuje u obliku neaktivnih metabolita, uglavnom fecesom (približno 61% doze), a u manjoj mjeri mokraćom (približno 36% doze).
English: Drinking alcohol may temporarily lower your blood pressure.
Croatian: Konzumiranje alkohola može privremeno sniziti krvni tlak.
English: You may take a CIALIS tablet at least 30 minutes before sexual activity.
Croatian: CIALIS tabletu možete uzeti najmanje 30 minuta prije seksualne aktivnosti.
English: Over a dose range of 2.5 to 20 mg, exposure (AUC) increases proportionally with dose.
Croatian: U rasponu doza od 2,5 do 20 mg izloženost (AUC) raste proporcionalno dozi.
English: - recently had a stroke within the last 6 months.
Croatian: - ako ste u posljednjih 6 mjeseci pretrpjeli moždani udar.
English: If you are taking any form of nitrate or are unsure tell your doctor.
Croatian: Ako uzimate bilo koji oblik nitrata ili niste sigurni, obavijestite svog liječnika.
English: If you forget to take CIALIS
Croatian: Ako ste zaboravili uzeti CIALIS
English: What CIALIS contains - The active substance is tadalafil.
Croatian: Što CIALIS sadrži - Djelatna tvar je tadalafil.
English: You may experience side effects described in section 4.
Croatian: Mogu se javiti nuspojave opisane u dijelu 4.
English: (1) Most of the patients had pre-existing cardiovascular risk factors (see section 4.4).
Croatian: (1) U većine bolesnika već su postojali kardiovaskularni faktori rizika (vidjeti dio 4.4).
English: Although other risk factors were present in some cases (such as age, diabetes, hypertension and previous hearing loss history) patients should be advised to stop taking tadalafil and seek prompt medical attention in the event of sudden decrease or loss of hearing.
Croatian: Iako su u nekim slučajevima bili prisutni i drugi faktori rizika (kao što su dob, šećerna bolest, hipertenzija i prethodan gubitak sluha u anamnezi), bolesnicima treba savjetovati da prestanu uzimati tadalafil i odmah zatraže medicinsku pomoć u slučaju iznenadnog slabljenja ili gubitka sluha.
English: Effects were seen in dogs that might indicate impairment of fertility.
Croatian: U pasa su opaženi učinci koji bi mogli upućivati na poremećaj plodnosti.
English: Most of the patients in whom these events have been reported had pre-existing cardiovascular risk factors.
Croatian: većine bolesnika u kojih su prijavljeni navedeni događaji već su postojali kardiovaskularni faktori rizika.
English: Tadalafil is readily absorbed after oral administration and the mean maximum observed plasma concentration (Cmax) is achieved at a median time of 2 hours after dosing.
Croatian: Tadalafil se lako apsorbira nakon peroralne primjene, a srednja maksimalna opažena koncentracija u plazmi (Cmax) se postiže 2 sata (medijan vremena) nakon doziranja.
English: This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac contractility.
Croatian: Ova selektivnost za PDE5 u odnosu na PDE3 važna je zato što je PDE3 enzim uključen u kontraktilnost srca.
English: Haemodialysis contributes negligibly to tadalafil elimination.
Croatian: Hemodijaliza zanemarivo pridonosi eliminaciji tadalafila.
English: CIALIS contains lactose.
Croatian: CIALIS sadrži laktozu.
English: If you have taken or are planning to take CIALIS, avoid excessive drinking (blood alcohol level of 0.08 % or greater), since this may increase the risk of dizziness when standing up.
Croatian: Ako ste uzeli ili planirate uzeti CIALIS, izbjegavajte prekomjernu konzumaciju alkohola (razina alkohola u krvi od 0,08% ili više) jer to može povećati rizik od omaglice pri ustajanju.
English: The European Medicines Agency has waived the obligation to submit the results of studies in all subsets of the paediatric population in the treatment of the erectile dysfunction.
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja u svim podskupinama pedijatrijske populacije za liječenje erektilne disfunkcije.
English: Symptoms include difficulty in starting to pass water, a feeling of not completely emptying the bladder and a more frequent need to pass water even at night.
Croatian: Simptomi uključuju otežan početak mokrenja, osjećaj da mjehur nije u potpunosti ispražnjen i pojačanu potrebu za mokrenjem, čak i noću.
English: If you experience sudden decrease or loss of vision, stop taking CIALIS and contact your doctor immediately.
Croatian: Ako osjetite iznenadno smanjenje ili gubitak vida, prestanite uzimati CIALIS i odmah se javite svom liječniku.
English: - are taking any form of organic nitrate or nitric oxide donors such as amyl nitrite.
Croatian: - ako uzimate bilo koji oblik organskih nitrata ili donore dušikova oksida poput amil nitrata.
English: Although this effect is minor and was of no clinical significance in this study, it should be considered when co-administering these medicinal products.
Croatian: Iako je taj učinak malen i nije imao klinički značaj za ispitivanje, treba ga uzeti u obzir pri istodobnoj primjeni navedenih lijekova.
English: This effect of age is not clinically significant and does not warrant a dose adjustment.
Croatian: Ovaj utjecaj dobi nije klinički značajan i ne zahtijeva prilagođavanje doze.
English: In this regard, study subjects whose blood pressure was well controlled, the reduction was minimal and similar to that seen in healthy subjects.
Croatian: U tom je pogledu u ispitanika u kojih je krvni tlak bio dobro kontroliran smanjenje bilo minimalno i podjednako onomu primijećenom u zdravih ispitanika.
English: Drinking alcohol may affect your ability to get an erection.
Croatian: Konzumiranje alkohola može utjecati na sposobnost postizanja erekcije.
English: CIALIS will not help you if you do not have erectile dysfunction.
Croatian: CIALIS Vam neće pomoći ako ne patite od erektilne disfunkcije.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim problemima nepodnošenja galaktoze, nedostatkom Lapp laktaze ili malapsorpcijom glukoze i galaktoze ne bi trebali uzimati ovaj lijek.
English: Analysis of phase 3 clinical trial data showed no difference in adverse events in patients taking tadalafil with or without antihypertensive medicinal products.
Croatian: Analiza podataka iz faze III kliničkih ispitivanja nije pokazala razliku u nuspojavama među bolesnicima koji su uzimali tadalafil sa ili bez antihipertenziva.
English: Some men taking CIALIS in clinical studies have reported dizziness.
Croatian: Neki muškarci koji su uzimali CIALIS u kliničkim ispitivanjima prijavili su omaglicu.
English: CIALIS has been shown to increase the effects of these medicines.
Croatian: Pokazalo se da CIALIS pojačava učinke tih lijekova.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of tadalafil in milk.
Croatian: Dostupni farmakodinamički/toksikološki podaci na životinjama pokazuju da se tadalafil izlučuje u mlijeko.
English: However, caution should be exercised when using tadalafil in patients treated with any alpha-blockers, and notably in the elderly.
Croatian: Ipak, tadalafil treba primjenjivati uz oprez u bolesnika liječenih alfa-blokatorima, a naročito u starijih bolesnika.
English: If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately.
Croatian: Ako imate erekciju koja traje dulje od 4 sata, odmah se javite liječniku.
English: These effects were not associated with changes in other parameters such as motility, morphology and FSH.
Croatian: Ovi učinci nisu bili povezani s promjenama drugih parametara, kao što su pokretljivost,
English: CIALIS, must not be used in men with cardiac disease for whom sexual activity is inadvisable.
Croatian: CIALIS se ne smije primjenjivati u muškaraca sa srčanim bolestima kojima se ne preporučuje seksualna aktivnost.
English: These effects are unlikely to lead to a lack of fertility.
Croatian: Nije vjerojatno da će navedeni učinci prouzročiti neplodnost.
English: • Drinking alcohol may affect your ability to get an erection so avoid excessive drinking with CIALIS.
Croatian: • Konzumiranje alkohola može utjecati na sposobnost postizanja erekcije pa treba izbjegavati prekomjernu konzumaciju alkohola s lijekom CIALIS.
English: If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result.
Croatian: Ako se prijapizam ne liječi odmah, može doći do oštećenja tkiva penisa i trajnog gubitka potencije.
English: In the pregnant rat the AUC for calculated free drug at this dose was approximately 18 times the human AUC at a 20 mg dose.
Croatian: U skotnih je štakorica pri toj dozi AUC izračunatog slobodnog lijeka bio približno 18 puta veći od AUC-a u ljudi pri dozi od 20 mg.
English: In addition, an updated RMP should be submitted
Croatian: Ažurirani RMP treba dostaviti:
English: Nitrates
Croatian: Nitrati
English: As this may be relevant for all patients exposed to tadalafil, the patient should be advised that in case of sudden visual defect, he should stop taking CIALIS and consult a physician immediately (see section 4.3).
Croatian: Budući da bi to moglo biti značajno za sve bolesnike izložene tadalafilu, bolesnicima treba savjetovati da u slučaju iznenadnog poremećaja vida prestanu uzimati CIALIS i odmah se obrate liječniku (vidjeti dio 4.3).
English: There was no impairment of fertility in male and female rats.
Croatian: Plodnost u mužjaka i ženki štakora nije bila umanjena.
English: CIALIS was studied in 4 clinical studies of 12 weeks duration enrolling over 1500 patients with signs and symptoms of benign prostatic hyperplasia.
Croatian: CIALIS je ispitan u 4 klinička ispitivanja u trajanju od 12 tjedana u kojima je sudjelovalo 1500 bolesnika sa znakovima i simptomima benigne hiperplazije prostate.
English: In addition, no changes in tadalafil concentrations were seen 3 hours after co-administration with alcohol.
Croatian: Nadalje, 3 sata nakon istodobne primjene s alkoholom nisu opažene promjene u koncentracijama tadalafila.
English: In a rat prenatal and postnatal development study, the no observed effect dose was 30 mg/kg/day.
Croatian: U istraživanju prenatalnog i postnatalnog razvoja u štakora, doza pri kojoj nisu opaženi učinci bila je 30 mg/kg na dan.
English: This reduced exposure can be anticipated to decrease the efficacy of tadalafil; the magnitude of decreased efficacy is unknown.
Croatian: Očekuje se da bi smanjena izloženost mogla umanjiti djelotvornost tadalafila, ali razmjer smanjenja djelotvornosti nije poznat.
English: Therefore there is the potential of drug interactions mediated by inhibition of transporters.
Croatian: Stoga su moguće interakcije između lijekova uslijed inhibicije prijenosnika.
English: The effect of tadalafil is more potent on PDE5 than on other phosphodiesterases.
Croatian: Djelovanje tadalafila na PDE5 snažnije je nego na druge fosfodiesteraze.
English: This drug is used to treat pulmonary arterial hypertension (i.e., high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e., high blood pressure in the lungs secondary to blood clots).
Croatian: Taj se lijek koristi za liječenje plućne arterijske hipertenzije (tj. povišenog krvnog tlaka u plućima) i kronične tromboembolijske plućne hipertenzije (tj. povišenog krvnog tlaka u plućima koji je posljedica krvnih ugrušaka).
English: In study subjects whose blood pressure was not controlled, the reduction was greater although this reduction was not associated with hypotensive symptoms in the majority of subjects.
Croatian: U ispitanika u kojih krvni tlak nije bio kontroliran smanjenje je bilo veće, ali u većine ispitanika nije bilo povezano s hipotenzivnim simptomima.
English: If you are taking riociguat or are unsure tell your doctor.
Croatian: Ako uzimate riocigvat ili niste sigurni, obavijestite svog liječnika.
English: This is thought to result from the combined effects of nitrates and tadalafil on the nitric oxide/cGMP pathway.
Croatian: Smatra se da je to posljedica kombiniranog djelovanja nitrata i tadalafila na signalni put dušikova oksida/cGMP-a.
English: Drinking alcohol may affect your ability to get an erection and may temporarily lower your blood pressure.
Croatian: Konzumiranje alkohola može utjecati na sposobnost postizanja erekcije i privremeno sniziti krvni tlak.
English: CIALIS has negligible influence on the ability to drive or use machines.
Croatian: CIALIS zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection.
Croatian: To dovodi do opuštanja glatkih mišića i dotoka krvi u tkivo penisa, čime se postiže erekcija.
English: In subjects taking multiple antihypertensives, the ambulatory-blood-pressure changes appeared to relate to the degree of blood-pressure control.
Croatian: U bolesnika koji su uzimali nekoliko antihipertenziva činilo se da su izmjerene promjene krvnog tlaka povezane sa stupnjem kontrole krvnog tlaka.
English: Dose adjustments are not required in elderly patients.
Croatian: Nije potrebno prilagođavati dozu u starijih bolesnika.
English: Since benign prostatic hyperplasia and prostate cancer may have the same symptoms, your doctor will check you for prostate cancer before starting treatment with CIALIS for benign prostatic hyperplasia.
Croatian: Budući da benigna hiperplazija i rak prostate mogu imati iste simptome, liječnik će napraviti pretrage za rak prostate prije početka primjene lijeka CIALIS za benignu hiperplaziju prostate.
English: The only pharmacodynamic effect was a small (3.5 bpm) increase in heart rate.
Croatian: Jedini farmakodinamički učinak bilo je malo ubrzanje srčanog ritma (3,5 otkucaja u minuti).
English: Frequency convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1000 to
Croatian: Kategorije učestalosti: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100),
English: The adverse reactions reported were transient, and generally mild or moderate.
Croatian: Prijavljene nuspojave bile su prolazne te u pravilu blagog ili umjerenog intenziteta.
English: In haemodialysis patients, Cmax was 41 % higher than that observed in healthy subjects.
Croatian: U bolesnika na hemodijalizi je Cmax bio 41% veći nego u zdravih ispitanika.
English: Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.
Croatian: Prije uvođenja bilo kakvog liječenja erektilne disfunkcije liječnici trebaju razmotriti kardiovaskularni status svojih bolesnika jer se uz seksualnu aktivnost veže određen stupanj srčanog rizika.
English: The recommended starting dose is one 10 mg tablet before sexual activity.
Croatian: Preporučena početna doza je jedna tableta od 10 mg koja se uzima prije seksualne aktivnosti.
English: This finding is consistent with the low affinity of tadalafil for PDE6 compared to PDE5.
Croatian: Ovaj je nalaz u skladu s niskim afinitetom tadalafila za PDE6 u odnosu na PDE5.
English: Cases of sudden hearing loss have been reported after the use of tadalafil.
Croatian: Prijavljeni su slučajevi iznenadnog gubitka sluha nakon primjene tadalafila.
English: When dogs were treated there was reduced sperm development in the testes.
Croatian: Kod primjene ovog lijeka u pasa primijećeno je smanjeno stvaranje sperme u testisima.
English: Healthy elderly subjects (65 years or over), had a lower oral clearance of tadalafil, resulting in 25 % higher exposure (AUC) relative to healthy subjects aged 19 to 45 years.
Croatian: Zdravi stariji ispitanici (65 godina i stariji) imali su manji klirens tadalafila nakon peroralne primjene, što je dovelo do 25% veće izloženosti (AUC) u odnosu na zdrave ispitanike u dobi od 19 do 45 godina.
English: Some medicines may be affected by CIALIS or they may affect how well CIALIS will work.
Croatian: CIALIS može utjecati na neke lijekove ili oni mogu utjecati na djelovanje lijeka CIALIS.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: The majority of headaches reported with CIALIS once-aday dosing are experienced within the first 10 to 30 days of starting treatment.
Croatian: U većini se slučajeva glavobolja prijavljena kod primjene lijeka CIALIS jedanput na dan javila unutar prvih 10 do 30 dana nakon početka liječenja.
English: Although it is not known if the event is directly related to tadalafil, if you experience decreased or sudden hearing loss, stop taking CIALIS and contact your doctor immediately.
Croatian: Iako nije poznato je li taj događaj izravno povezan s tadalafilom, ako primijetite slabljenje ili iznenadan gubitak sluha, prestanite uzimati CIALIS i odmah se javite svom liječniku.
English: Physicians should consider the potential cardiac risk of sexual activity in patients with pre-existing cardiovascular disease.
Croatian: Liječnici moraju razmotriti potencijalni rizik za srce tijekom seksualne aktivnosti u bolesnika s postojećom kardiovaskularnom bolešću.
English: CIALIS has been shown to improve these urinary symptoms as early as 1-2 weeks after starting treatment.
Croatian: Pokazalo se da CIALIS ublažava te simptome u mokraćnom sustavu već 1-2 tjedna nakon početka liječenja.
English: Three studies were conducted in men to assess the potential effect on spermatogenesis of CIALIS 10 mg (one 6-month study) and 20 mg (one 6-month and one 9-month study) administered daily.
Croatian: Provedena su tri ispitivanja u muškaraca kako bi se procijenio potencijalni utjecaj svakodnevne primjene lijeka CIALIS u dozi od 10 mg (jedno 6-mjesečno ispitivanje) i 20 mg (jedno 6-mjesečno i jedno
English: The rate and extent of absorption of tadalafil are not influenced by food, thus CIALIS may be taken with or without food.
Croatian: Hrana ne utječe na brzinu i opseg apsorpcije tadalafila, tako da se CIALIS može uzimati s hranom ili bez nje.
English: Due to increased tadalafil exposure (AUC), limited clinical experience and the lack of ability to influence clearance by dialysis, once-a-day dosing of CIALIS is not recommended in patients with severe renal impairment.
Croatian: Zbog povećane izloženosti tadalafilu (AUC), ograničenog kliničkog iskustva i nemogućnosti da se na klirens utječe dijalizom, ne preporučuje se primjena lijeka CIALIS jedanput na dan u bolesnika s teškim oštećenjem bubrežne funkcije.
English: The mean oral clearance for tadalafil is 2.5 l/h and the mean half-life is 17.5 hours in healthy subjects.
Croatian: Prosječan klirens tadalafila nakon peroralne primjene iznosi 2,5 l/h, a prosječan poluvijek u zdravih ispitanika iznosi 17,5 sati.
English: Before treatment with CIALIS
Croatian: Prije liječenja lijekom CIALIS
English: CYP2C9 substrates (e.g. R-warfarin)
Croatian: Supstrati CYP2C9 (npr. R-varfarin)
English: Consequently, it is not expected to be clinically active at observed metabolite concentrations.
Croatian: Stoga se ne očekuje se da će u opaženim koncentracijama biti klinički aktivan.
English: Tadalafil pharmacokinetics in healthy subjects are linear with respect to time and dose.
Croatian: Linearnost/nelinearnost Farmakokinetika tadalafila u zdravih je ispitanika linearna s obzirom na vrijeme i dozu.
English: Interaction studies were conducted with 10 mg and/or 20 mg tadalafil, as indicated below.
Croatian: Provedena su ispitivanja interakcija s tadalafilom u dozama od 10 mg i/ili 20 mg, kako je opisano u nastavku.
English: Pharmacokinetics determined with a population approach in patients with erectile dysfunction are similar to pharmacokinetics in subjects without erectile dysfunction.
Croatian: Farmakokinetika utvrđena populacijskim pristupom u bolesnika s erektilnom disfunkcijom bila je slična farmakokinetici u ispitanika bez erektilne disfunkcije.
English: de la Industria 30, 28108 Alcobendas, Madrid, Spain.
Croatian: Proizvođač: Lilly S.A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Španjolska
English: Not all packs sizes may be marketed.
Croatian: Na tržištu se ne moraju nalaziti sve veličine pakiranja.
English: If you have a heart problem you should tell your doctor.
Croatian: Ako imate tegoba sa srcem, obavijestite o tome svog liječnika.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTERS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP BLISTER
English: In clinical studies, tadalafil (5, 10 and 20 mg) was shown to augment the hypotensive effects of nitrates.
Croatian: U kliničkim se ispitivanjima pokazalo da tadalafil (5, 10 i 20 mg) pojačava hipotenzivne učinke nitrata.
English: Tadalafil has vasodilator properties, resulting in mild and transient decreases in blood pressure (see section 5.1) and as such potentiates the hypotensive effect of nitrates (see section 4.3).
Croatian: Tadalafil ima vazodilatacijska svojstva koja dovode do blagih i prolaznih sniženja krvnog tlaka (vidjeti dio 5.1) i tako pojačavaju hipotenzivni učinak nitrata (vidjeti dio 4.3).
English: 2 film-coated tablets 4 film-coated tablets 8 film-coated tablets 10 film-coated tablets 12 film-coated tablets
Croatian: 2 filmom obložene tablete 4 filmom obložene tablete 8 filmom obloženih tableta 10 filmom obloženih tableta 12 filmom obloženih tableta
English: The overall safety results from this study were generally consistent with the known safety profile of tadalafil and with adverse events (AEs) expected in a paediatric DMD population receiving corticosteroids.
Croatian: Sveukupni rezultati za sigurnost iz ovog ispitivanja u načelu su bili u skladu s poznatim sigurnosnim profilom tadalafila, uz nuspojave očekivane u pedijatrijskoj populaciji s DMD-om koja prima kortikosteroide.
English: Absolute bioavailability of tadalafil following oral dosing has not been determined.
Croatian: Apsolutna bioraspoloživost tadalafila nakon peroralne primjene nije utvrđena.
English: Priapism and anatomical deformation of the penis
Croatian: Prijapizam i anatomske deformacije penisa
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 12 November 2002
Croatian: Datum prvog odobrenja: 12. studenog 2002.
English: In patients receiving concomitant antihypertensive medicinal products, tadalafil 20 mg may induce a blood pressure decrease, which (with the exception of alpha blockers -see above-) is, in general, minor and not likely to be clinically relevant.
Croatian: U bolesnika koji se istodobno liječe antihipertenzivima tadalafil u dozi od 20 mg može izazvati sniženje krvnog tlaka koje je (uz izuzetak alfa-blokatora - vidjeti prethodni odlomak) u pravilu malo i nije vjerojatno da će biti klinički značajno.
English: CIALIS contains the active substance tadalafil which belongs to a group of medicines called phosphodiesterase type 5 inhibitors.
Croatian: CIALIS sadrži djelatnu tvar tadalafil koja pripada skupini lijekova koji se nazivaju inhibitorima fosfodiesteraze tipa 5.
English: The appropriateness of continued use of the daily regimen should be reassessed periodically.
Croatian: Primjerenost kontinuirane svakodnevne primjene lijeka treba povremeno iznova procijeniti.