FrancophonIA/ELRC3.0 huggingface dataset:
English: For a pack containing a single bottle, write only one date.
Croatian: Na pakiranju koje sadrži samo jednu bočicu, zapišite samo jedan datum.
English: Treatment should be symptomatic and supportive.
Croatian: Liječenje mora biti simptomatsko i suportivno.
English: Not known (frequency cannot be estimated from the available data):
Croatian: Nepoznato (ne može procijeniti iz dostupnih podataka)
English: 1 drop in the affected eye or eyes twice a day - morning and night.
Croatian: 1 kap u oboljelo oko ili oči, dva puta na dan - ujutro i navečer.
English: Do not drive or use machines until your vision is clear.
Croatian: Nemojte upravljati vozilima niti strojevima sve dok Vam se vid ne razbistri.
English: Only use AZOPT for your eyes.
Croatian: AZOPT primjenjujte samo za oči.
English: It reduces pressure within the eye.
Croatian: On smanjuje tlak u oku.
English: What AZOPT is and what it is used for
Croatian: Što je AZOPT i za što se koristi
English: Like all medicines, this medicine can cause side effects, although not everyone gets them.
Croatian: Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave iako se neće javiti kod svakoga.
English: White to off-white suspension.
Croatian: Bijela do bjelkasta suspenzija.
English: Do not swallow or inject.
Croatian: Ne gutati niti injicirati.
English: • If you take drops in both eyes, repeat the steps for your other eye.
Croatian: • Ako primjenjujete kapljice u oba oka, ponovite ove korake na drugom oku.
English: About 20% of the dose has been accounted for in urine as metabolite.
Croatian: Oko 20% doze u urinu pripisuje se metabolitu.
English: B-2870 Puurs, Belgium.
Croatian: B-2870 Puurs, Belgija.
English: This helps to stop AZOPT getting into the rest of the body.
Croatian: Tako ćete spriječiti da AZOPT prijeđe u ostatak tijela.
English: The drop will go in here (picture 1)
Croatian: Tu se nanosi kap (slika 1).
English: No dose adjustment in elderly patients is necessary.
Croatian: Nije potrebna prilagodba doze kod starijih bolesnika.
English: • Get the AZOPT bottle and a mirror
Croatian: • Uzmite bočicu AZOPTA i ogledalo
English: • Hold the bottle, pointing down, between your thumb and middle finger
Croatian: • Bočicu držite okrenutu prema dolje, između palca i srednjeg prsta
English: If the pressure in the eye is too high, it can damage your sight.
Croatian: Ukoliko je tlak u oku previsok, može dovesti do oštećenja vida.
English: Date of first authorisation: 9 March 2000 Date of latest renewal: 29 January 2010
Croatian: Datum posljednje obnove odobrenja: 29. siječnja 2010.
English: Use a single drop as soon as you remember, and then go back to your regular routine.
Croatian: Ukapajte jednu kap čim se sjetite i nastavite s uobičajenom rutinom primjene.
English: Binding to plasma proteins is not extensive (about 60%).
Croatian: Vezanje na proteine plazme nije izraženo (oko 60%).
English: Other medicines and AZOPT
Croatian: Drugi lijekovi i AZOPT
English: Contact with soft contact lenses is to be avoided.
Croatian: Treba izbjegavati kontakt s mekim kontaktnim lećama.
English: Write down the date you opened each bottle in the space below and in the space on the bottle label and box.
Croatian: Zapišite datum kada ste otvorili pojedinu bočicu u prostor ispod te u prostor na naljepnici bočice i kutiji.
English: If you use more AZOPT than you should
Croatian: Ako primijenite više AZOPTA nego što ste trebali
English: • After using AZOPT, press a finger to the corner of your eye, by the nose (picture 3) for at least
Croatian: • Nakon primjene AZOPTA, pritisnite prstom kut oka blizu nosa (slika 3) na najmanje 1 minutu.
English: Detailed information on this medicine is available on the European Medicines Agency website http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu.
English: You must throw away a bottle four weeks after you first opened it, to prevent infections.
Croatian: Bočicu morate odbaciti četiri tjedna nakon prvog otvaranja, kako biste spriječili infekcije.
English: AZOPT is not to be used by infants, children or adolescents under 18 years of age unless advised by your doctor.
Croatian: AZOPT ne smiju koristiti dojenčad, djeca ili adolescenti ispod 18 godina starosti osim ako je to preporučio Vaš liječnik.
English: Not Known: asthma
Croatian: Nepoznato: astma
English: What AZOPT is and what it is used for What you need to know before you use AZOPT How to use AZOPT
Croatian: Što je AZOPT i za što se koristi Što morate znati prije nego počnete primjenjivati AZOPT Kako primjenjivati AZOPT
English: Do not use AZOPT - if you have severe kidney problems.
Croatian: Nemojte primjenjivati AZOPT - ako imate teške probleme sa bubrezima.
English: If you have further questions, ask your doctor for advice.
Croatian: Ako imate dodatnih pitanja, potražite savjet liječnika.
English: This medicine contains 3.35 µg benzalkonium chloride per drop (= 1 dose) which is equivalent to 0.01% or 0.1 mg/ml.
Croatian: Ovaj lijek sadrži 3,35 µg benzalkonijevog klorida po kapi (= 1 doza), što odgovara 0,01% ili 0,1 mg/ml.
English: The events were mild and did not affect the overall discontinuation rates in the studies (see also section 4.8).
Croatian: Događaji su bili blagi i nisu utjecali na ukupnu stopu prekida primjene u studijama (vidjeti također dio 4.8.).
English: AZOPT eye drops are used to treat high pressure in the eye.
Croatian: AZOPT kapi za oko se koriste za liječenje povišenog očnog tlaka.
English: Some patients may have a better response with one drop three times a day.
Croatian: Neki bolesnici bolje reagiraju na primjenu jedne kapi tri puta dnevno.
English: If you stop using AZOPT without speaking to your doctor, the pressure in your eye will not be controlled which could lead to loss of sight.
Croatian: Ako ste prekinuli primjenu AZOPTA bez dogovora s Vašim liječnikom, očni tlak neće biti pod kontrolom što može dovesti do gubitka vida.
English: Examples include medicines used to treat diabetes and infections and also diuretics (water tablets).
Croatian: Primjerice lijekove za liječenje dijabetesa i infekcija kao i diuretike (tablete za izmokravanje).
English: • Known hypersensitivity to sulphonamides (see also section 4.4).
Croatian: • poznata preosjetljivost na sulfonamide (vidjeti također dio 4.4).
English: The recommended dose is
Croatian: Preporučeno doziranje je
English: The following adverse reactions have been reported with brinzolamide 10mg/ml eye drops, suspension and are classified according to the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1000), very rare (<1/10,000), or not known (cannot be estimated from the available data).
Croatian: Niže navedene nuspojave zabilježene su s brinzolamidom 10 mg/ml kapi za oko, suspenzijom i razvrstane su prema sljedećoj učestalosti: vrlo često (≥1/10), često (≥1/100 do <1/10), manje često (≥1/1000 do <1/100), rijetko (≥1/10 000 do <1/1000), vrlo rijetko (<1/10 000) ili nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Brinzolamide has not been studied in pre-term infants (less than 36 weeks gestational age) or those less than 1 week of age.
Croatian: Primjena brinzolamida nije ispitivana kod nedonoščadi (manje od 36 tjedana gestacijske dobi) ili mlađih od 1 tjedna starosti.
English: The adverse reactions were obtained from clinical trials and post-marketing spontaneous reports.
Croatian: Nuspojave su zabilježene u kliničkim ispitivanjima i postmarketinškim spontanim prijavama.
English: Do not use this medicine after the expiry date which is stated on the bottle and box after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na bočici i kutiji iza oznake „EXP“.
English: What you need to know before you use AZOPT
Croatian: Što morate znati prije nego počnete primjenjivati AZOPT
English: If you get too much in your eyes, rinse it all out with warm water.
Croatian: Ako ste ukapali previše, isperite oko s toplom vodom.
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from AZOPT therapy taking in to account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je odlučiti da li prekinuti dojenje ili prekinuti/suzdržati se od liječenja AZOPTOM uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: • Hyperchloraemic acidosis.
Croatian: • hiperkloremična acidoza.
English: Potential rebound effects following cessation of treatment with AZOPT have not been studied; the IOP-lowering effect is expected to last for 5-7 days.
Croatian: Potencijani povratni (rebound) učinci nakon prestanka liječenja AZOPTOM nisu ispitivani; očekivani učinak smanjenja IOT-a je 5-7 dana.
English: Studies in animals have shown reproductive toxicity following systemic administration (see also section 5.3).
Croatian: Ispitivanja na životinjama pokazala su reproduktivnu toksičnost nakon sistemske primjene (vidjeti također dio 5.3).
English: - The active substance is brinzolamide.
Croatian: - Djelatna tvar je brinzolamid.
English: - General side effects: bad taste.
Croatian: - Opće nuspojave: loš okus u ustima.
English: Do not use AZOPT unless clearly indicated by your doctor.
Croatian: Ne koristite AZOPT osim u slučaju da to izričito traži Vaš liječnik.
English: Instruct patients to keep the bottle tightly closed when not in use.
Croatian: Preporučite bolesniku da bočicu drži dobro zatvorenom kada se ne koristi.
English: Alcon Cusí, S.A., Camil Fabra 58, 08320 El Masnou, Barcelona, Spain.
Croatian: Alcon Cusí, S.A., Camil Fabra 58, 08320 El Masnou, Barcelona, Španjolska.
English: Carbonic anhydrase activity was approximately 40-70% of predose levels.
Croatian: Aktivnost karboanhidraze je bila približno 40-70% od vrijednosti izmjerene prije primjene.
English: Uncommon: foreign body in eye
Croatian: Manje često: strano tijelo u oku
English: AZOPT is indicated to decrease elevated intraocular pressure in:
Croatian: AZOPT je indiciran za smanjenje povišenog intraokularnog tlaka kod:
English: When used as monotherapy or adjunctive therapy, the dose is one drop of AZOPT in the conjunctival sac of the affected eye(s) twice daily.
Croatian: Kada se daje kao monoterapija ili dodatna terapija, doza je jedna kap AZOPTA u vrećicu spojnice oboljelog oka (očiju) dvaput dnevno.
English: However, accumulation of brinzolamide is unlikely as renal elimination is the major route.
Croatian: Ipak, akumulacija briznolamida se ne očekuje s obzirom da je renalna eliminacija glavni put.
English: If you are using other eye drops, leave at least 5 minutes between putting in AZOPT and the other drops.
Croatian: Ako istodobno koristite druge kapi za oči, pričekajte najmanje 5 minuta između primjene AZOPTA i ostalih kapi.
English: Dysgeusia (bitter or unusual taste in the mouth following instillation) was the most frequently reported systemic adverse reaction associated with the use of AZOPT during clinical studies.
Croatian: Disgeuzija (gorak ili neobičan okus u ustima nakon ukapavanja) je najčešće zabilježena sistemska nuspojava povezana sa primjenom AZOPTA tijekom kliničkih studija.
English: AZOPT contains benzalkonium chloride
Croatian: AZOPT sadrži benzalkonijev klorid
English: What AZOPT contains
Croatian: Što AZOPT sadrži
English: Brinzolamide is eliminated primarily by renal excretion (approximately 60%).
Croatian: Brinzolamid se eliminira prvenstveno izlučivanjem putem bubrega (približno 60%).
English: Caution should be used in treating these patients and close monitoring of intraocular pressure (IOP) is recommended.
Croatian: Potreban je oprez u liječenju ovih bolesnika, te se preporučuje pomno praćenje intraokularnog tlaka (IOT).
English: • Do not squeeze the bottle: it is designed so that a gentle press on the bottom is all that it needs
Croatian: Nemojte stiskati bočicu - napravljena je tako da je dovoljan samo lagani pritisak na njeno dno
English: Animal studies with brinzolamide demonstrated no effect on fertility.
Croatian: Ispitivanja na životinjama provedena s brinzolamidom nisu pokazala utjecaj na plodnost.
English: The dose should not exceed one drop in the affected eye(s) three times daily.
Croatian: Doza ne smije biti više od jedne kapi u oboljelo oko (oči) tri puta dnevno.
English: Women who may become pregnant are advised to use effective contraception during AZOPT treatment.
Croatian: Ženama kod kojih postoji mogućnost da ostanu trudne preporučuje se korištenje djelotvorne kontracepcije tijekom liječenja s AZOPTOM.
English: B-2870 Puurs
Croatian: B-2870 Puurs Belgija
English: If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation.
Croatian: Ako se primijete znakovi ozbiljnih reakcija ili preosjetljivost, primjenu lijeka je potrebno prekinuti.
English: The safety and efficacy of AZOPT in infants, children and adolescents aged 0 to 17 years have not been established.
Croatian: Sigurnost i djelotvornost AZOPTA u dojenčadi, djece i adolescenata u dobi od 0 do 17 godina nisu ustanovljene.
English: Tiny amounts of hydrochloric acid or sodium hydroxide are added to keep acidity levels (pH levels) normal.
Croatian: Malene količine kloridne kiseline ili natrijevog hidroksida su dodane za održavanje normalne razine kiselosti (vrijednosti pH).
English: It is likely caused by passage of the eye drops in the nasopharynx via the nasolacrimal canal.
Croatian: Vjerojatno je uzrokovana prolazom kapi u nazofarinks preko nazolakrimalnog kanala.
English: Use with caution in patients with risk of renal impairment because the possible risk of metabolic acidosis (see section 4.2).
Croatian: Primijeniti s oprezom kod bolesnika kod kojih postoji rizik od poremećaja bubrega zbog mogućeg rizika od metaboličke acidoze (vidjeti dio 4.2).
English: AZOPT has a minor influence on the ability to drive and use machines.
Croatian: AZOPT ima minimalan utjecaj na sposobnost upravljanja vozilima i rada sa strojevima.
English: These findings occurred at doses that caused metabolic acidosis with decreased body weight gain in dams and decreased foetal weights.
Croatian: Ovi rezultati dobiveni su kod doza koje su uzrokovale metaboličku acidozu sa smanjenjem prirasta tjelesne težine kod ženki i smanjenjem težine ploda.
English: It could infect the drops
Croatian: Može doći do inficiranja kapi.
English: If affected, take care when driving or using machines.
Croatian: Dogodi li Vam se to, budite oprezni pri upravljanju vozilima i radu sa strojevima.
English: If you stop using AZOPT
Croatian: Ako prestanete primjenjivati AZOPT
English: You may find that your vision is blurred for a time just after using AZOPT.
Croatian: Može se dogoditi da Vam se vid zamuti na neko vrijeme odmah nakon primjene AZOPTA.
English: Serum electrolyte levels (particularly potassium) and blood pH levels must be monitored.
Croatian: Mora se pratiti razina elektrolita u serumu (naročito kalija) i razina pH krvi.
English: No long term data are available on the use of AZOPT as adjunctive therapy to travoprost(see also section 5.1).
Croatian: Nisu dostupni dugoročni podaci o primjeni AZOPTA kao dodatne terapije s travoprostom (vidjeti također dio 5.1).
English: An additional decrease in mean diurnal IOP of 3.2 to 3.4 mmHg for the brinzolamide group and 3.2 to 4.2 mmHg for the timolol group were observed.
Croatian: Dodatno smanjenje prosječnog diurnalnog IOT-a od 3,2 do 3,4 mmHg zabilježeno je za grupu na terapiji brinzolamidom i od 3,2 do 4,2 mmHg za grupu na terapiji timololom.
English: If more than one topical ophthalmic medicinal product is being used, the medicines must be administered at least 5 minutes apart.
Croatian: Ako se primjenjuje više od jednog oftalmološkog lijeka za lokalnu primjenu, lijekovi se moraju primijeniti s najmanje 5 minuta razmaka.
English: Since brinzolamide and its main metabolite are excreted predominantly by the kidney, AZOPT is therefore contra-indicated in such patients (see also section 4.3).
Croatian: Budući da se brinzolamid i njegov glavni metabolit izlučuju uglavnom putem bubrega, AZOPT je kontraindiciran kod takvih bolesnika (vidjeti također dio 4.3).
English: It is expected that inhibitors of CYP3A4 such as ketoconazole, itraconazole, clotrimazole, ritonavir and troleandomycin will inhibit the metabolism of brinzolamide by CYP3A4.
Croatian: Očekivano je da inhibitori CYP3A4 kao što su ketokonazol, itrakonazol, klotrimazol, ritonavir i troleandomicin inhibiraju metabolizam brinzolamida preko CYP3A4.
English: Nasolacrimal occlusion or gently closing the eyelid after instillation may help reduce the incidence of this effect (see also section 4.2).
Croatian: Nazolakrimalna okluzija ili lagano zatvaranje vjeđe nakon ukapavanja mogu pomoći u smanjenju incidencije ove nuspojave (vidjeti također dio 4.2).
English: Specific interaction studies with other medicinal products have not been performed with AZOPT.
Croatian: Studije o specifičnim interakcijama AZOPTA s drugim lijekovima nisu provedene.
English: Animal studies have shown the excretion of minimal levels of brinzolamide in breast milk following oral administration.
Croatian: Ispitivanja na životinjama pokazala su izlučivanje minimalnih količina brinzolamida u majčino mlijeko nakon oralne primjene.
English: AZOPT has not been studied in patients with severe renal impairment (creatinine clearance < 30 ml/min) or in patients with hyperchloraemic acidosis.
Croatian: AZOPT nije ispitivan u bolesnika s teškim oštećenjem bubrega (klirens kreatinina <30 ml/min) niti u bolesnika s hiperkloremičnom acidozom.
English: There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and AZOPT.
Croatian: Postoji mogućnost aditivnog učinka na poznate sistemske učinke inhibicije karboanhidraze u bolesnika koji primaju oralni inhibitor karboanhidraze i AZOPT.
English: If blurred vision occurs at instillation, the patient must wait until the vision clears before driving or using machines.
Croatian: Ako dođe do zamućenja vida nakon primjene, potrebno je pričekati da se vid razbistri, prije upravljanja vozilima ili strojevima.
English: The possible role of brinzolamide on corneal endothelial function has not been investigated in patients with compromised corneas (particularly in patients with low endothelial cell count).
Croatian: Moguća uloga brinzolamida na funkciju endotela rožnice nije istraživana kod bolesnika s oštećenjem rožnice (osobito kod bolesnika s malim brojem stanica endotela).
English: • open-angle glaucoma as monotherapy in adult patients unresponsive to beta-blockers or in adult patients in whom betablockers are contraindicated, or as adjunctive therapy to beta-blockers or prostaglandin analogues (see also section 5.1).
Croatian: očne hipertenzije glaukoma otvorenog kuta kao monoterapija u odraslih bolesnika koji ne reagiraju na beta-blokatore ili u kojih su beta-blokatori kontraindicirani, ili kao dodatna terapija uz beta-blokatore ili analoge prostaglandina (vidjeti također dio 5.1).
English: Electrolyte imbalance, development of an acidotic state, and possible nervous system effects may occur.
Croatian: Moguća je pojava neravnoteže elektrolita, nastanka acidoze i mogućih učinaka na živčani sustav.
English: Pharmacotherapeutic group: Antiglaucoma preparations and miotics, carbonic anhydrase inhibitors, ATC code: S01EC04
Croatian: Farmakoterapijska skupina: lijekovi za liječenje glaukoma i miotici, inhibitori karboanhidraze, ATK oznaka: S01EC04
English: Brinzolamide, an inhibitor of carbonic anhydrase II (CA-II), the predominant iso-enzyme in the eye, with an in vitro IC50 of 3.2 nM and a Ki of 0.13 nM against CA-II.
Croatian: Brinzolamid je inhibitor karboanhidraze II (CA-II), predominantog izoenzima u oku, s IC50 od 3,2 nM in vitro i Ki od 0,13 nM prema CA- II.
English: Brinzolamide is not an inhibitor of cytochrome P-450 isozymes.
Croatian: Brinzolamid nije inhibitor citrokrom P-450 izoenzima.
English: In small short-term clinical trials, approximately 12.5% of paediatric patients were observed to experience adverse reactions, the majority of which were local, non-serious ocular reactions such as conjunctival hyperaemia, eye irritation, eye discharge, and lacrimation increased (see also section 5.1).
Croatian: U manjim kratkoročnim kliničkim ispitivanja nuspojave su zabilježene kod otprilike 12,5% pedijatrijskih bolesnika, od kojih su većina bile lokalne, neozbiljne okularne reakcije poput konjunktivalne hiperemije, iritacije oka, iscjetka iz oka i pojačanog suzenja (vidjeti također dio 5.1).
English: To prevent contamination of the dropper tip and suspension, care must be taken not to touch the eyelids, surrounding areas or other surfaces with the dropper tip of the bottle.
Croatian: Da bi se spriječila kontaminacija vrha kapaljke i suspenzije, potrebno je paziti da se vrhom kapaljke ne dotiču vjeđe, okolna područja ili druge površine.
English: AZOPT contains brinzolamide which belongs to a group of medicines called carbonic anhydrase inhibitors.
Croatian: AZOPT sadrži brinzolamid koji pripada skupini lijekova koja se naziva inhibitori karboanhidraze.
English: The use of AZOPT is not recommended during pregnancy or breast-feeding.
Croatian: Primjena AZOPTA ne preporučuje se tijekom trudnoće ili dojenja.
English: In subjects with the highest degree of renal impairment inhibition of total CA activity was greater although it was inferior to 90% at steady-state.
Croatian: Kod ispitanika s najvećim stupnjem oštećenja bubrega inhibicija ukupne aktivnosti CA je bila veća, iako manja od 90% u stanju dinamičke ravnoteže.
English: In clinical studies involving 2732 patients treated with AZOPT as monotherapy or adjunctive therapy to timolol maleate 5 mg/ml, the most frequently reported treatment-related adverse reactions were: dysgeusia (6.0%) (bitter or unusual taste, see description below) and temporary blurred vision (5.4%) upon instillation, lasting from a few seconds to a few minutes (see also section 4.7).
Croatian: U kliničkim studijama koje su uključile 2732 bolesnika liječenih AZOPTOM, kao monoterapija ili dodatna terapija s timolol maleatom 5 mg/ml najčešće zabilježene nuspojave povezane s terapijom bile su: disgeuzija (6,0%) (gorak ili neobičan okus, vidjeti opis niže) i privremeno zamagljen vid (5,4%) nakon ukapavanja, u trajanju od nekoliko sekundi do nekoliko minuta (vidjeti također dio 4.7).
English: In plasma, both brinzolamide and Ndesethylbrinzolamide concentrations are low and generally below assay quantitation limits (<7.5 ng/ml).
Croatian: U plazmi su koncentracije i brinzolamida i N-desetilbrinzolamida niske i općenito su ispod limita testa za određivanje (<7,5 ng/ml).
English: Benzalkonium chloride, which is commonly used as a preservative in ophthalmic products, has been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy.
Croatian: Benzalkonijev klorid, koji se uobičajeno primjenjuje kao konzervans u oftalmološkim preparatima, može uzrokovati točkastu keratopatiju i/ili toksičnu ulcerativnu keratopatiju.
English: The result is a reduction in intraocular pressure (IOP) which is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.
Croatian: Rezultat je redukcija intraokularnog tlaka (IOT) koji je glavni faktor rizika u patogenezi oštećenja očnog živca i gubitka vidnog polja kod glaukoma.
English: Rare: memory impairment, somnolence Not Known: tremor, hypoaesthesia, ageusia
Croatian: Rijetko: zaboravljivost, somnolencija Nepoznato: tremor, hipoestezija, ageuzija
English: The cytochrome P-450 isozymes responsible for metabolism of brinzolamide include CYP3A4 (main), CYP2A6, CYP2C8 and CYP2C9.
Croatian: Izoenzimi citrokroma P-450, koji su odgovorni za metabolizam brinzolamida su CYP3A4 (glavni), CYP2A6, CYP2C8 i CYP2C9.
English: Patients with significant renal tubular immaturity or abnormalities should only receive brinzolamide after careful consideration of the risk benefit balance because of the possible risk of metabolic acidosis.
Croatian: Bolesnici s nerazvijenim ili abnormalnim renalnim tubulima smiju primiti brinzolamid tek nakon pažljive procjene rizika i koristi zbog mogućeg rizika od metaboličke acidoze.