FrancophonIA/ELRC3.0 huggingface dataset:
English: In previous studies, the pharmacokinetics of atazanavir was not altered by rifabutin.
Slovenian: Pri predhodnih študijah rifabutin ni vplival na farmakokinetiko atazanavirja.
English: What you need to know before you take Atazanavir Mylan
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Atazanavir Mylan
English: Lamotrigine should be used with caution in combination with atazanavir/ritonavir.
Slovenian: Lamotrigin je treba v kombinaciji z atazanavirjem/ritonavirjem uporabljati previdno.
English: Each capsule contains 112 mg lactose monohydrate
Slovenian: Ena kapsula vsebuje 112 mg laktoze monohidrata.
English: Study conducted in HIV infected patients
Slovenian: Študija, izvedena pri bolnikih, okuženih z virusom HIV.
English: * In a combined analysis from several clinical studies, atazanavir/ritonavir 300/100 mg coadministered with tenofovir disoproxil fumarate 300 mg (n=39) was compared to atazanavir/ritonavir 300/100 mg (n=33).
Slovenian: *Kombinirana analiza več kliničnih študij, v katerih so uporabo atazanavirja/ritonavirja 300 mg/100 mg skupaj s dizoproksiltenofovirijevim fumaratom v odmerku 300 mg (n=39) primerjali z uporabo atazanavirja/ritonavirja 300 mg/100 mg (n=33).
English: 2nd Trimester (n=9)
Slovenian: Drugo trimesečje nosečnosti (n=9)
English: All patients HIV RNA <400 copies/ml, %
Slovenian: Vsi bolniki HIV RNA <400 kopij/ml, %
English: The proportion of patients with HIV RNA < 400 copies/ml were 53% and 43% for ATV/RTV and 54% and 46% for LPV/RTV at weeks 48 and 96 respectively.
Slovenian: Delež bolnikov s HIV RNA < 400 kopij/ml je bil v 48. tednu pri kombinaciji ATV/RTV 53 %, pri kombinaciji LPV/RTV pa 54 %.
English: Oral use Capsules should be swallowed whole.
Slovenian: peroralna uporaba Kapsule morate pogoltniti cele.
English: This decrease in atazanavir Cmin, might negatively impact the efficacy of atazanavir.
Slovenian: To zmanjšanje vrednosti Cmin atazanavirja lahko negativno vpliva na učinkovitost atazanavirja.
English: 14-OH clarithromycin Cmax ↓72%
Slovenian: 14-OH klaritromicin Cmax ↓72 %
English: The concomitant use of quinidine is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba kinidina je kontraindicirana (glejte poglavje 4.3).
English: The mechanism of interaction is CYP3A4 and UGT1A1 inhibition.
Slovenian: Mehanizem interakcije je zaviranje CYP3A4 in UGT1A1.
English: HDPE bottle with polypropylene screw cap containing 60 capsules.
Slovenian: HDPE plastenke s polipropilensko navojno zaporko s po 60 trdimi kapsulami
English: • atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol)
Slovenian: • atorvastatin, pravastatin in fluvastatin (zdravila za zniževanje holesterola v krvi),
English: There were fewer treatment discontinuations in the unboosted atazanavir group (1 vs. 4 subjects in the atazanavir + ritonavir group).
Slovenian: Zdravljenje je bilo manjkrat prekinjeno v skupini z atazanavirjem brez okrepitve (1 bolnik v primerjavi s 4 bolniki v skupini z atazanavirjem + ritonavirjem).
English: Co-administration with atazanavir has the potential to increase or decrease warfarin concentrations.
Slovenian: Pri sočasni uporabi atazanavirja se koncentracije varfarina lahko povečajo ali zmanjšajo.
English: Three of 20 infants (15%) born to women treated with atazanavir/ritonavir 300/100 mg and four of 20 infants (20%) born to women treated with atazanavir/ritonavir 400/100 mg experienced grade 3-4 bilirubin.
Slovenian: Pri treh od 20 dojenčkov (15 %) katerih matere so se zdravile z atazanavirjem/ritonavirjem v odmerku 300 mg/100 mg in pri štirih od 20 dojenčkov (20 %), ki so se rodili materam, ki so se zdravile z atazanavirjem/ritonavirjem v odmerku 400 mg/100 mg, so poročali o vrednosti bilirubina stopnje 3-4.
English: Each capsule contains 84 mg lactose monohydrate
Slovenian: Ena kapsula vsebuje 84 mg laktoze monohidrata.
English: The geometric mean (CV%) for atazanavir Cmin and AUC were 120 (109) ng/ml and 14874 (91) ng•h/ml, respectively.
Slovenian: Geometrijska srednja vrednost Cmin (KV %) atazanavirja je znašala 120 (109) ng/ml, geometrijska srednja vrednost AUC (KV %) atazanavirja pa 14.874 (91) ng•h/ml.
English: Co-administration of atazanavir with ritonavir and proton pump inhibitors is not recommended.
Slovenian: Sočasne uporabe atazanavirja z ritonavirjem in zaviralcev protonske črpalke ne priporočamo.
English: Atazanavir is primarily hepatically metabolised and increased plasma concentrations were observed in patients with hepatic impairment (see sections 4.2 and 4.3).
Slovenian: Atazanavir se primarno presnavlja v jetrih in pri bolnikih z okvaro jeter so opažali zvišanje njegove koncentracije v plazmi (glejte poglavji 4.2 in 4.3).
English: Midazolam and triazolam are extensively metabolised by CYP3A4.
Slovenian: Midazolam in triazolam se v veliki meri presnavljata s CYP3A4.
English: No dosage adjustments are needed for fluconazole and atazanavir.
Slovenian: Odmerkov flukonazola in atazanavirja ni treba prilagajati.
English: Study 045 is a randomised, multicenter trial comparing atazanavir /ritonavir (300/100 mg once daily) and atazanavir /saquinavir (400/1,200 mg once daily), to lopinavir + ritonavir (400/100 mg fixed dose combination twice daily), each in combination with tenofovir disoproxil fumarate (see sections 4.5 and 4.8) and one NRTI, in patients with virologic failure on two or more prior regimens containing at least one PI, NRTI, and NNRTI.
Slovenian: Študija 045 je randomizirano, multicentrično preskušanje, ki je primerjalo atazanavir/ritonavir (300 mg/100 mg enkrat na dan) in atazanavir/sakvinavir (400 mg/1.200 mg enkrat na dan) z lopinavirjem + ritonavirjem (400 mg/100 mg v fiksni kombinaciji v odmerku dvakrat na dan), vse v kombinaciji z dizoproksiltenofovirijevim fumaratom (glejte poglavji 4.5 in 4.8) in enim NRTIjem pri bolnikih z virološko neuspešnim zdravljenjem z eno ali več predhodnimi shemami, ki so obsegale vsaj en zaviralec proteaz, NRTI in NNRTI.
English: Swallow the capsules whole.
Slovenian: Kapsule pogoltnite cele.
English: Tenofovir disoproxil fumarate Cmin ↑29% (↑21% ↑36%)
Slovenian: dizoproksiltenofovirijev fumarat Cmin ↑29 % (↑21 % ↑36 %)
English: Co-administration of lurasidone with atazanavir is contraindicated as this may increase lurasidone-related toxicity (see section 4.3).
Slovenian: Sočasna uporaba lurasidona z atazanavirjem je kontraindicirana, saj lahko atazanavir okrepi toksične učinke lurasidona (glejte poglavje 4.3).
English: * When compared to atazanavir 300 mg and ritonavir 100 mg without nevirapine.
Slovenian: *Pri primerjavi atazanavirja 300 mg in ritonavirja 100 mg brez nevirapina.
English: Indinavir is also associated with indirect (unconjugated) hyperbilirubinaemia due to inhibition of UGT.
Slovenian: Tudi indinavir je povezan z zvišanjem indirektnega (nekonjugiranega) bilirubina v krvi zaradi zavrtja UGT.
English: 14-OH clarithromycin Cmin ↓62%
Slovenian: 14-OH klaritromicin Cmin ↓62 %
English: If an oral contraceptive is administered with atazanavir /ritonavir, it is recommended that the oral contraceptive contain at least 30 μg of ethinyloestradiol and that the patient be reminded of strict compliance with this contraceptive dosing regimen.
Slovenian: Če se peroralni kontraceptiv uporablja skupaj z atazanavirjem/ritonavirjem je priporočljivo, da peroralni kontraceptiv vsebuje vsaj 30 μg etinilestradiola.
English: No teratogenic effects were observed in rats or rabbits at maternally toxic doses.
Slovenian: Pri podganah in kuncih niso opazili teratogenih učinkov v odmerkih, toksičnih za samice-matere.
English: The rash usually disappears within 2 weeks without any change to your treatment.
Slovenian: Izpuščaj običajno izzveni v 2 tednih brez kakršne koli spremembe zdravljenja z zdravilom Atazanavir Mylan.
English: Each capsule contains 168 mg lactose monohydrate
Slovenian: Ena kapsula vsebuje 168 mg laktoze monohidrata.
English: While the concentration of ethinyloestradiol was increased with atazanavir given alone, due to both UGT and CYP3A4 inhibition by atazanavir, the net effect of atazanavir/ritonavir is a decrease in ethinyloestradiol levels because of the inducing effect of ritonavir.
Slovenian: Zaradi zaviralnega učinka atazanavirja na UGT in CYP3A4 so se koncentracije etinilestradiola pri uporabi atazanavirja samega povečale, vendar pa so se zaradi inducirajočega učinka ritonavirja pri uporabi atazanavirja/ritonavirja vrednosti etinilestradiola zmanjšale.
English: This medicine comes in blister packs containing 30 or 30 x 1 (unit dose) capsules or in bottles containing 30 or 90 hard capsules.
Slovenian: Zdravilo je na voljo v pretisnih omotih s 30 ali 30 x 1 (posamezni odmerek) kapsulo ali v plastenkah s po 30 ali 90 trdimi kapsulami.
English: The increased incidence of benign hepatic adenomas in female mice was likely secondary to cytotoxic liver changes manifested by single-cell necrosis and is considered to have no relevance for humans at intended therapeutic exposures.
Slovenian: Večja incidenca benignih jetrnih adenomov pri mišjih samicah je verjetno posledica citotoksičnih sprememb jeter, ki se kažejo z nekrozami posameznih jetrnih celic.
English: The mechanism of interaction is CYP3A4 inhibition by atazanavir and/or ritonavir.
Slovenian: Mehanizem interakcije je zaviranje CYP3A4 z atazanavirjem in/ali ritonavirjem.
English: Protease inhibitors: The co-administration of atazanavir/ritonavir and other protease inhibitors has not been studied but would be expected to increase exposure to other protease inhibitors.
Slovenian: Zaviralci proteaz: Sočasne uporabe atazanavirja/ritonavirja in drugih zaviralcev proteaz niso raziskovali.
English: For bottles: Once opened, use within 90 days.
Slovenian: Za plastenke: Po prvem odprtju, porabite v 90 dneh.
English: There was less hyperbilirubinaemia and jaundice in the unboosted atazanavir group compared with the atazanavir + ritonavir group (18 and 28 subjects, respectively).
Slovenian: V skupini z atazanavirjem brez okrepitve so poročali o manj primerih hiperbilirubinemije in zlatenice kot v skupini z atazanavirjem + ritonavirjem (18 bolnikov v primerjavi z 28 bolniki).
English: Both asymptomatic first-degree (23%) and second-degree (1%) atrioventricular block were reported in paediatric patients.
Slovenian: Pri pediatričnih bolnikih so poročali o asimptomatskem atrioventrikularnem bloku prve (23 %) in druge (1 %) stopnje.
English: Co- administration of atazanavir /ritonavir and these glucocorticoids is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4).
Slovenian: Sočasne uporabe atazanavirja/ritonavirja in teh glukokortikoidov ne priporočamo, razen v primerih, ko možne koristi zdravljenja prevladajo nad tveganjem za pojav sistemskih kortikosteroidnih učinkov (glejte poglavje 4.4).
English: potential increase in the risk of ALT elevations (see section 4.3).
Slovenian: za zvišanje vrednosti ALT (glejte poglavje 4.3).
English: Lactose monohydrate Crospovidone Magnesium stearate
Slovenian: Vsebina kapsul laktoza monohidrat krospovidon magnezijev stearat.
English: In HIV-infected patients with atazanavir/ritonavir at the recommended dose 300/100 mg once daily
Slovenian: Pri z virusom HIV okuženih bolnikih, ki so se zdravili z atazanavirjem/ritonavirjem v priporočenem odmerku 300 mg/100 mg enkrat na dan
English: No significant effect on methadone concentrations was observed.
Slovenian: Pomembnega vpliva na koncentracije metadona niso opazili.
English: Reversible elevations in indirect (unconjugated) bilirubin related to inhibition of UDP-glucuronosyl transferase (UGT) have occurred in patients receiving atazanavir (see section 4.8).
Slovenian: Pri bolnikih, ki so se zdravili z atazanavirjem, se je pojavilo reverzibilno zvišanje indirektnega (nekonjugiranega) bilirubina, kar je povezano z zaviranjem UDP-glukuroniltransferaze (UGT) (glejte poglavje 4.8).
English: When co-administered with tenofovir disoproxil fumarate, it is recommended that atazanavir 300 mg be given with ritonavir 100 mg and tenofovir disoproxil fumarate 300 mg (all as a single dose with food).
Slovenian: Pri sočasni uporabi dizoproksiltenofovirijevega fumarata je priporočljivo atazanavir v odmerku 300 mg uporabljati skupaj z ritonavirjem v odmerku 100 mg in dizoproksiltenofovirijevim fumaratom v odmerku 300 mg (vse v obliki enkratnega odmerka skupaj s hrano).
English: Co-administration of diltiazem and atazanavir /ritonavir has not been studied.
Slovenian: Sočasne uporabe diltiazema in atazanavirja/ritonavirja niso raziskovali.
English: Coadministration of a single 300 mg dose of atazanavir and 100 mg dose of ritonavir with a light meal resulted in a 33% increase in the AUC and a 40% increase in both the Cmax and the 24 hour concentration of atazanavir relative to the fasting state.
Slovenian: V primerjavi z uporabo na tešče so se pri uporabi enkratnega 300 mg odmerka atazanavirja in 100 mg odmerka ritonavirja skupaj z lahkim obrokom vrednosti AUC, Cmax in 24-urne koncentracije atazanavirja povečale, in sicer AUC za 33 %, Cmax in 24-urna koncentracija pa za 40 %.
English: uncommon: dyspnoea
Slovenian: občasni: dispneja
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - 'Combination antiretroviral therapy') nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične okužbe.
English: The use of atazanavir in children less than 3 months of age and weighing less than 5 kg has not been studied due to the risk of serious complications.
Slovenian: Tega zdravila ne smete dajati otrokom, mlajšim od 3 mesecev in s telesno maso, manjšo od 5 kg. Uporabe atazanavirja pri otrocih, mlajših od 3 mesecev in s telesno maso, manjšo od 5 kg, zaradi tveganja za pojav resnih zapletov niso raziskovali.
English: HIV RNA <50 copies/ml, %
Slovenian: HIV RNA <50 kopij/ml, %
English: A dose reduction of buprenorphine may be considered
Slovenian: Odmerek buprenorfina bo morda treba zmanjšati.
English: Six of 20 (30%) women on atazanavir/ritonavir 300/100 mg and 13 of 21 (62%) women on atazanavir /ritonavir 400/100 mg experienced grades 3 to 4 hyperbilirubinaemia.
Slovenian: Pri 6 od 20 bolnic (30 %), ki so prejemale atazanavir/ritonavir v odmerku 300 mg/100 mg, in 13 od 21 bolnic (62 %), ki so prejemale zdravilo atazanavir/ritonavir v odmerku 400 mg/100 mg, so poročali o pojavu hiperbilirubinemije stopnje 3 do 4.
English: Co-administration of voriconazole and atazanavir with ritonavir is not recommended unless an assessment of the benefit/risk to the patient justifies the use of voriconazole (see section 4.4).
Slovenian: Sočasna uporaba vorikonazola in atazanavirja z ritonavirjem ni priporočljiva, razen če ocena koristi/tveganj pri bolniku upraviči uporabo vorikonazola (glejte poglavje 4.4).
English: Mean baseline CD4 cell count was 214 cells/mm
Slovenian: Srednje število celic CD4 v izhodišču je bilo 214 celic/mm
English: whereas caution should be used with co-administration of atazanavir and parenteral midazolam.
Slovenian: Pri sočasni uporabi atazanavirja in parenteralnega midazolama je potrebna previdnost.
English: Pregnancy and postpartum
Slovenian: Nosečnost in poporodno obdobje
English: Co-administration with atazanavir may result in increased concentrations of the PDE5 inhibitor and an increase in PDE5-inhibitor-associated adverse events.
Slovenian: Pri sočasni uporabi atazanavirja se koncentracije zaviralca PDE5 lahko povečajo in s tem se poveča tudi pojavnost neželenih učinkov zaviralca PDE5.
English: HERBAL PRODUCTS St. John's wort (Hypericum perforatum)
Slovenian: šentjanževka (Hypericum perforatum)
English: In clinical trials of antiretroviral treatment naive patients treated with unboosted atazanavir, the I50L substitution, sometimes in combination with an A71V change, is the signature resistance substitution for atazanavir.
Slovenian: Odrasli bolniki, ki se predhodno še niso zdravili s protiretrovirusnimi zdravili V kliničnih preskušanjih pri bolnikih, ki se predhodno še niso zdravili s protiretrovirusnimi zdravili, je bila pri zdravljenju z atazanavirjem brez okrepitve farmakokinetike substitucija I50L, včasih v kombinaciji s spremembo A71V, značilna odpornost na substitucijo proti atazanavirju.
English: The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing this disease.
Slovenian: Nekateri od številnih dejavnikov tveganja za pojav te bolezni so lahko trajanje kombiniranega protiretrovirusnega zdravljenja, uporaba kortikosteroidov, uživanje alkohola, hudo zmanjšanje imunskega odziva in višji indeks telesne mase.
English: Due to CYP3A4 inhibition by atazanavir, concentrations of quetiapine are expected to increase.
Slovenian: Ker atazanavir zavira CYP3A4, pričakujemo povečanje koncentracij kvetiapina.
English: CD4 Mean Change from Baseline, cells/mm All patients
Slovenian: Srednja sprememba števila celic CD4 od izhodišča, celice/mm Vsi bolniki
English: In HIV-infected patients (n=33, combined studies), multiple dosing of atazanavir 300 mg once daily with ritonavir 100 mg once daily with food produced a geometric mean (CV%) for atazanavir, Cmax of 4466 (42%) ng/ml, with time to Cmax of approximately 2.5 hours.
Slovenian: Pri bolnikih, okuženih z virusom HIV (n=33, kombinirane študije), je bila pri ponavljajočih se odmerkih atazanavirja v odmerku 300 mg enkrat na dan z ritonavirjem v odmerku 100 mg enkrat na dan skupaj s hrano geometrijska srednja vrednost Cmax (KV %) atazanavirja 4.466 (42 %) ng/ml.
English: 14-OH clarithromycin AUC ↓70%
Slovenian: 14-OH klaritromicin 14-OH klaritromicin AUC ↓70 %
English: No significant effect on didanosine and stavudine concentrations was observed.
Slovenian: Pomembnih vplivov na koncentracije didanozina in stavudina niso opazili.
English: Cardiac monitoring is recommended based on the presence of clinical findings (e.g., bradycardia).
Slovenian: Ob prisotnosti kliničnih znakov (npr. bradikardije) je priporočljivo spremljanje delovanja srca.
English: M36, M46, I54, A71, V82 L10, I15, K20, V32, E35, S37, F53, I62, G73, I84, L90
Slovenian: M36, M46, I54, A71, V82 10-20 % L10, I15, K20, V32, E35, S37, F53, I62, G73, I84, L90 a Število bolnikov s pari genotipov, označenimi kot virusni neodziv (HIV RNA ≥ 400 kopij/ml).
English: 3rd Trimester (n=20)
Slovenian: Tretje trimesečje nosečnosti (n=20)
English: Atazanavir AUC ↑7% (↓2% ↑17%) Atazanavir Cmax ↑2% (↓4% ↑8%) Atazanavir Cmin ↑15% (↑2% ↑29%)
Slovenian: atazanavir AUC ↑7% (↑2% ↑17%) atazanavir Cmax ↑2% (↓4% ↑8%) atazanavir Cmin ↑15% (↑2% ↑29%) elbasvir AUC: ↑376% (↑307% elbasvir Cmax: ↑315% (↑246% elbasvir Cmin: ↑545% (↑451%
English: uncommon: nephrolithiasis a, haematuria, proteinuria, pollakiuria, interstitial nephritis, chronic kidney disease a;
Slovenian: občasni: nefrolitiaza a, hematurija, proteinurija, polakisurija, intersticijski nefritis, kronična ledvična bolezen a;
English: A safe and effective dose in combination with atazanavir has not been established for sildenafil when used to treat pulmonary arterial hypertension.
Slovenian: Varnega in učinkovitega odmerka sildenafila za zdravljenje pljučne arterijske hipertenzije, ki bi ga lahko uporabljali skupaj z atazanavirjem, niso ugotovili.
English: A change in dose may occur when switching between other formulations and capsules.
Slovenian: Pri zamenjavi med drugimi farmacevtskimi oblikami in kapsulami se bo odmerek morda spremenil.
English: If you forget to take Atazanavir Mylan
Slovenian: Če ste pozabili vzeti zdravilo Atazanavir Mylan
English: Co-administration of quetiapine with atazanavir is contraindicated as atazanavir may increase quetiapine-related toxicity.
Slovenian: Sočasna uporaba kvetiapina z atazanavirjem je kontraindicirana, saj lahko atazanavir okrepi toksične učinke kvetiapina.
English: Voriconazole AUC ↑561% (↑451%
Slovenian: vorikonazol AUC ↑561 %
English: Dose related asymptomatic prolongations in PR interval with atazanavir have been observed in clinical studies.
Slovenian: Pri zdravljenju z atazanavirjem so v kliničnih študijah opazili od odmerka odvisno asimptomatsko podaljšanje intervala PR.
English: Among patients who received atazanavir 400 mg once daily or atazanavir 300 mg with ritonavir 100 mg once daily, the only adverse reactions of any severity reported very commonly with at least a possible relationship to regimens containing atazanavir and one or more NRTIs were nausea (20%), diarrhoea (10%), and jaundice (13%).
Slovenian: Pri bolnikih, ki so prejemali atazanavir v odmerku 400 mg enkrat na dan ali atazanavir v odmerku 300 mg skupaj z ritonavirjem v odmerku 100 mg enkrat na dan, so bili kot zelo pogosti opisani le naslednji neželeni učinki vseh jakosti, ki bi vsaj lahko bili povezani z uporabo atazanavirja v kombinaciji z enim nukleozidnim/nukleotidnim zaviralcem reverzne transkriptaze (NRTI) ali več: navzea (20 %), driska (10 %) in zlatenica (13 %).
English: • oedema (swelling)
Slovenian: • edem (oteklina);
English: No dosage adjustment is needed.
Slovenian: Odmerka ni treba prilagajati.
English: The pharmacokinetic data from HIV-infected pregnant women receiving atazanavir capsules with ritonavir are presented in Table 8.
Slovenian: V preglednici 8 so predstavljeni farmakokinetični podatki, pridobljeni pri z virusom HIV okuženih nosečnicah, ki so prejemale atazanavir v obliki kapsul skupaj z ritonavirjem.
English: No dosage adjustment is needed in patients with renal impairment.
Slovenian: Pri bolnikih z okvaro ledvic odmerka ni treba prilagajati.
English: Among experienced patients treated with atazanavir 300 mg once daily with 100 mg ritonavir once daily for a median duration of 95 weeks, 53% had Grade 3-4 total bilirubin elevations.
Slovenian: Pri predhodno že zdravljenih bolnikih, ki so atazanavir v odmerku 300 mg enkrat na dan skupaj z ritonavirjem v odmerku 100 mg enkrat na dan prejemali v povprečju 95 tednov, se je zvišanje vrednosti bilirubina 3. in 4. stopnje pojavilo pri 53 % bolnikov.
English: A. MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Slovenian: IZDELOVALCI, ODGOVORNI ZA SPROŠČANJE SERIJ
English: It is important that you take Atazanavir Mylan with food (a meal or a substantial snack) as this helps the body absorb the medicine.
Slovenian: Zdravilo Atazanavir Mylan skupaj s hrano in pijačo Pomembno je, da zdravilo Atazanavir Mylan jemljete skupaj s hrano (med kosilom ali z obilnejšim obrokom) in tako telesu olajšate absorpcijo zdravila.
English: Serious skin rash, including Stevens-Johnson syndrome, has been reported in patients taking atazanavir.
Slovenian: Pri bolnikih, ki so se zdravili z atazanavirjem, so poročali o pojavu resnega kožnega izpuščaja, vključno s Stevens-Johnsonovim sindromom.
English: (atazanavir 400 mg once daily)
Slovenian: (atazanavir 400 mg enkrat na dan)
English: Clarithromycin Cmax ↑50% (↑32%
Slovenian: klaritromicin Cmax ↑50 %
English: Among naive patients treated with atazanavir 300 mg once daily with 100 mg ritonavir once daily for a median duration of 96 weeks, 48% had Grade 3-4 total bilirubin elevations (see section 4.4).
Slovenian: Pri predhodno še nezdravljenih bolnikih, ki so atazanavir v odmerku 300 mg enkrat na dan skupaj z ritonavirjem v odmerku 100 mg enkrat na dan prejemali v povprečju 96 tednov, se je zvišanje vrednosti bilirubina 3. in 4. stopnje pojavilo pri 48 % bolnikov (glejte poglavje 4.4).