FrancophonIA/ELRC3.0 huggingface dataset:
English: Imprida HCT is contraindicated in patients with hypercalcaemia and should only be used after correction of any pre-existing hypercalcaemia.
Slovenian: Zdravilo Imprida HCT je kontraindicirano pri bolnikih s hiperkalciemijo in ga je mogoče uporabljati šele po korekciji morebitne že prisotne hiperkalciemije.
English: In animal studies, reproductive toxicity was observed at high doses (see section 5.3).
Slovenian: V študijah na živalih so pri velikih odmerkih opazili škodljiv vpliv na sposobnost razmnoževanja (glejte poglavje 5.3).
English: • allergic reaction with symptoms such as rash, itching
Slovenian: • alergijska reakcija s simptomi, kot sta izpuščaj ali srbenje
English: If excessive hypotension occurs with Imprida HCT, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline.
Slovenian: Če se med uporabo zdravila Imprida HCT pojavi čezmerna hipotenzija, je treba bolnika poleči in mu, če je potrebno, dati intravensko infuzijo fiziološke raztopine.
English: Furthermore, concomitant use of Imprida HCT and NSAIDs may lead to worsening of renal function and an increase in serum potassium.
Slovenian: Poleg tega lahko sočasna uporaba zdravila Imprida HCT in NSAIDs povzroča poslabšanje delovanja ledvic in zvišanje koncentracije kalija v serumu.
English: Imprida HCT is not recommended in early pregnancy and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at this stage (see section “Pregnancy and breastfeeding”).
Slovenian: Zdravila pa ne smete jemati, če ste več kot 3 mesece noseči, ker lahko jemanje v tem obdobju povzroči resno škodo vašemu otroku (glejte poglavje “Nosečnost in dojenje”).
English: The safety of Imprida HCT has been evaluated at its maximum dose of 10 mg/320 mg/25 mg in one controlled short-term (8 weeks) clinical study with 2,271 patients, 582 of whom received valsartan in combination with amlodipine and hydrochlorothiazide.
Slovenian: Varnost zdravila Imprida HCT so ocenjevali pri uporabi njegovega najvišjega odmerka 10 mg/320 mg/25 mg, in sicer v eni kotrolirani kratkotrajni (8-tedenski) klinični študiji z 2.271 bolniki, od katerih jih je 582 prejemalo valsartan v kombinaciji z amlodipinom in s hidroklorotiazidom.
English: Alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
Slovenian: Za uporabo med dojenjem je bolje izbrati drugo zdravilo z dokazanimi varnostnimi lastnostmi še posebno če gre za dojenje novorojenčka ali nedonošenčka.
English: Some of these substances could interact with the hydrochlorothiazide component of Imprida HCT (see interactions related to HCT).
Slovenian: Nekatere od navedenih snovi bi lahko medsebojno delovale s hidroklorotiazidom v zdravilu Imprida HCT (glejte medsebojno delovanje, ki se nanaša na amlodipin drugo
English: • fast heart beat
Slovenian: • hitro bitje srca
English: Imprida HCT is used to treat high blood pressure in adult patients who are already taking amlodipine, valsartan and hydrochlorothiazide and who may benefit from taking one tablet containing all three substances.
Slovenian: Zdravilo Imprida HCT uporabljamo za zdravljenje visokega krvnega tlaka pri odraslih bolnikih, ki že jemljejo amlodipin, valsartan in hidroklorotiazid in bi jim ustrezalo jemanje ene same tablete, ki vsebuje vse tri zdravilne učinkovine.
English: In case of diuretic-induced dehydration, there is an increased risk of acute renal failure, especially with high doses of iodine products.
Slovenian: Pri bolnikih, ki so zaradi jemanja diuretikov dehidrirani, obstaja povečano tveganje za akutno odpoved ledvic, posebno pri uporabi visokih odmerkov jodiranih kontrastnih sredstev.
English: In clinical interaction studies, amlodipine did not affect the pharmacokinetics of atorvastatin, digoxin, warfarin or
Slovenian: V kliničnih študijah medsebojnega delovanja amlodipin ni vplival na farmakokinetiko atorvastatina, digoksina, varfarina ali ciklosporina.
English: Amlodipine is unlikely to be removed by haemodialysis.
Slovenian: Ni verjetno, da bi amlodipin odstranili z dializo.
English: The use of Imprida HCT in children and adolescents under 18 years of age is not recommended.
Slovenian: Pri otrocih in mladostnikih, ki so stari manj kot 18 let, uporaba zdravila Imprida HCT ni priporočena.
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Slovenian: Otroke, katerih matere so prejemale antagoniste angiotenzina II, je treba pozorno spremljati zaradi možnosti hipotenzije (glejte poglavji 4.3 in 4.4).
English: The degree to which hydrochlorothiazide is removed by haemodialysis has not been established.
Slovenian: Ni ugotovljeno, v kolikšni meri je mogoče s hemodializo odstraniti hidroklorotiazid iz telesa.
English: 280 film-coated tablets
Slovenian: 280 filmsko obloženih tablet
English: This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active substance amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of Imprida HCT.
Slovenian: Grenivka in grenivkin sok lahko namreč povzročita zvišanje koncentracije zdravilne učinkovine amlodipina v krvi, kar lahko pripelje do nepredvidljivega povečanja učinka zdravila Imprida HCT pri zniževanju krvnega tlaka.
English: Due to the risk of hypokalaemia, hydrochlorothiazide should be administered with caution when associated with medicinal products that could induce torsades de pointes, in particular Class Ia and Class III antiarrhythmics and
Slovenian: Zaradi nevarnosti hipokaliemije je potrebna previdnost pri uporabi hidroklorotiazida v kombinaciji z zdravili, ki lahko sprožijo torsades de pointes, zlasti z antiaritmiki skupin Ia in III in z nekaterimi antipsihotiki.
English: In one rat study, adverse effects were found on male fertility (see section 5.3).
Slovenian: V eni študiji na podganah so ugotovili neželene učinke na plodnost pri samcih (glejte poglavje 5.3).
English: Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloraemia) and hypovolaemia resulting from excessive diuresis.
Slovenian: Preveliko odmerjanje hidroklorotiazida je povezano s pomanjkanjem elektrolitov (s hipokaliemijo in hipokloremijo) in s hipovolemijo, do česar pride zaradi prekomernega odvajanja vode.
English: Cellulose microcrystalline Crospovidone Silica, colloidal anhydrous Magnesium stearate
Slovenian: Jedro tablete mikrokristalna celuloza krospovidon brezvoden koloidni silicijev dioksid magnezijev stearat
English: It is best to take the tablet at the same time each day.
Slovenian: Priporočljivo je, da vzamete zdravilo vsak dan ob istem času, najbolje zjutraj.
English: The use of Angiotensin II Receptor Antagonists (AIIRAs) is not recommended during the first trimester of pregnancy (see section 4.4).
Slovenian: Uporaba antagonistov angiotenzina II v prvem trimesečju nosečnosti ni priporočljiva (glejte poglavje 4.4).
English: Concomitant treatment with ciclosporin may increase the risk of hyperuricaemia and gout-type complications.
Slovenian: Sočasno zdravljenje s ciklosporinom lahko poveča tveganje za hiperurikemijo in za zaplete protinske narave.
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and if appropriate, alternative therapy should be started.
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti in, če je primerno, začeti alternativno zdravljenje.
English: Medicinal products used in the treatment of gout (probenecid, sulfinpyrazone and allopurinol)
Slovenian: zdravila za zdravljenje protina (probenecid, sulfinpirazon in alopurinol)
English: Heart failure and coronary artery disease
Slovenian: Srčno popuščanje in koronarna bolezen
English: Therefore, Imprida HCT is not recommended in this population.
Slovenian: Iz tega razloga uporaba zdravila Imprida HCT ni priporočena pri tej skupini bolnikov.
English: • high level of calcium, fat or sodium in the blood
Slovenian: • visoka raven kalcija, maščob ali natrija v krvi
English: Stopping your treatment with Imprida HCT may cause your disease to get worse.
Slovenian: Če ste prenehali jemati zdravilo Imprida HCT Prenehanje zdravljenja z zdravilom Imprida HCT lahko povzroči poslabšanje vaše bolezni.
English: Frequency Imprida HCT
Slovenian: Pogostnost Imprida HCT
English: You can take Imprida HCT with or without food.
Slovenian: Zdravilo Imprida HCT lahko vzamete s hrano ali brez nje.
English: Administration of valsartan to patients with hypertension results in a drop in blood pressure without affecting pulse rate.
Slovenian: Valsartan pri bolnikih s hipertenzijo zniža krvni tlak, ne da bi vplival na srčno frekvenco.
English: Treatment can be continued once blood pressure has been stabilised.
Slovenian: Ko se krvni tlak stabilizira, je z zdravljenjem možno nadaljevati.
English: Thiazide diuretics, including hydrochlorothiazide, have been reported to exacerbate or activate systemic lupus erythematosus.
Slovenian: Poročali so, da tiazidni diuretiki, vključno s hidroklorotiazidom, poslabšajo ali aktivirajo sistemski eritematozni lupus.
English: Other metabolic disturbances
Slovenian: Druge presnovne motnje
English: If any of the above applies to you, do not take Imprida HCT and talk to your doctor.
Slovenian: Če kaj od naštetega velja za vas, ne vzemite zdravila Imprida HCT, temveč povejte zdravniku.
English: CYP3A4 inducers (anticonvulsant agents [e.g. carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone], rifampicin, Hypericum perforatum [St. John's wort])
Slovenian: induktorji CYP3A4 (antiepileptiki [npr. karbamazepin, fenobarbital, fenitoin, fosfenitoin, primidon], rifampicin, Hypericum perforatum [šentjanževka])
English: Periodic determinations of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.
Slovenian: Za odkrivanje morebitnega neravnovesja elektrolitov je treba občasno v ustreznih intervalih določati koncentracije elektrolitov v serumu.
English: • inflammation of the stomach lining or of the pancreas, gingival overgrowth, abnormal liver function test
Slovenian: • vnetje želodčne sluznice ali trebušne slinavke, čezmerna rast dlesni, nenormalne vrednosti testov jetrne funkcije
English: Severe renal impairment (GFR <30 ml/min/1.73 m2), anuria and patients undergoing dialysis.
Slovenian: Huda okvara ledvic (hitrost glomerulne filtracije <30 ml/min/1,73 m2), anurija in bolniki na dializi.
English: The rate and extent of absorption of amlodipine, valsartan and hydrochlorothiazide from Imprida HCT are the same as when administered as individual dosage forms.
Slovenian: Hitrosti in obsegi absorpcije amlodipina, valsartana in hidroklorotiazida se ne razlikujejo od tistih pri odmerjanju posameznih sestavin.
English: Hepatic impairment, biliary cirrhosis or cholestasis.
Slovenian: Okvara jeter, biliarna ciroza ali holestaza.
English: In a subgroup of 283 patients focusing on ambulatory blood pressure monitoring, clinically and statistically superior reductions in 24-hour systolic and diastolic blood pressures were observed with the triple combination compared to valsartan/hydrochlorothiazide, valsartan/amlodipine, and hydrochlorothiazide/amlodipine.
Slovenian: V podskupini 283 bolnikov, ki so jim krvni tlak merili ambulantno, so opažali klinično in statistično večje znižanje 24-urnega sistoličnega/diastoličnega krvnega tlaka pri uporabi trojne kombinacije v primerjavi s kombinacijami valsartan/ hidroklorotiazid, valsartan/amlodipin in hidroklorotiazid/amlodipin.
English: The safety profile of Imprida HCT presented below is based on clinical studies performed with Imprida HCT and the known safety profile of the individual components amlodipine, valsartan and hydrochlorothiazide.
Slovenian: Spodaj navedene varnostne lastnosti zdravila Imprida HCT se nanašajo na podatke iz študij z zdravilom Imprida HCT in na znane varnostne lastnosti njegovih posameznih sestavin amlodipina, valsartana in hidroklorotiazida.
English: In the 8-week controlled clinical study, changes in laboratory parameters observed with the combination of Imprida HCT were minor and consistent with the pharmacological mechanism of action of the monotherapy agents.
Slovenian: V 8-tedenski kontrolirani klinični študiji so bile pri uporabi kombinacije v zdravilu Imprida HCT spremembe vrednosti laboratorijskih parametrov majhne in v skladu s farmakološkim načinom delovanja posameznih sestavin.
English: If Imprida HCT is used during breast-feeding, doses should be kept as low as possible.
Slovenian: Če bolnica uporablja zdravilo Imprida HCT v času dojenja, naj uporablja čim nižje odmerke.
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti in, če je primerno, začeti alternativno zdravljenje (glejte poglavji 4.3 in
English: • high level of sugar in the blood
Slovenian: • visoka raven sladkorja v krvi
English: Treatment of essential hypertension as substitution therapy in adult patients whose blood pressure is adequately controlled on the combination of amlodipine, valsartan and hydrochlorothiazide (HCT), taken either as three single-component formulations or as a dual-component and a single-component formulation.
Slovenian: Zdravljenje esencialne hipertenzije kot nadomestno zdravilo za odrasle bolnike, katerih krvni tlak je ustrezno urejen z uporabo kombinacije amlodipina, valsartana in hidroklorotiazida (HCT), ki jih jemljejo bodisi kot tri zdravila s posameznimi učinkovinami ali pa kot zdravilo z dvema učinkovinama v kombinaciji z zdravilom z eno učinkovino.
English: There was no effect on the fertility of rats treated with amlodipine (males for 64 days and females 14 days prior to mating) at doses up to 10 mg/kg/day (8 times* the maximum recommended human dose of 10 mg on a mg/m basis).
Slovenian: Pri podganah, ki so jim dajali amlodipin (samcem 64 dni, samicam pa 14 dni pred parjenjem) v odmerkih do 10 mg/kg/dan (8-kratnik* največjega priporočenega 10 mg odmerka za ljudi na podlagi mg/m2), ni bilo nikakršnega vpliva na plodnost.
English: Imprida HCT combines three antihypertensive compounds with complementary mechanisms to control blood pressure in patients with essential hypertension: amlodipine belongs to the calcium antagonist class and valsartan to the angiotensin II antagonist class of medicines and hydrochlorothiazide belongs to the thiazide diuretics class of medicines.
Slovenian: Zdravilo Imprida HCT vsebuje tri antihipertenzivne učinkovine s komplementarnimi mehanizmi delovanja za obvladanje krvnega tlaka pri bolnikih z esencialno hipertenzijo: amlodipin spada med zaviralce kalcijevih kanalčkov, valsartan med antagoniste angiotenzina II in hidroklorotiazid v skupino tiazidnih diuretikov.
English: Cases of photosensitivity reactions have been reported with thiazide diuretics (see section 4.8).
Slovenian: Pri uporabi tiazidnih diuretikov so opisovali primere fotosenzitivnostnih reakcij (glejte poglavje 4.8).
English: OUTER CARTON OF MULTIPACK (WITH BLUE BOX)
Slovenian: ZUNANJA ŠKATLA SKUPNEGA PAKIRANJA (VKLJUČNO Z “BLUE BOX” PODATKI)
English: Valsartan Inhibitors of the uptake transporter (rifampicin, ciclosporin) or efflux transporter (ritonavir)
Slovenian: valsartan zaviralci privzemnega prenašalca (rifampicin, ciklosporin) ali izlivnega prenašalca (ritonavir)
English: Thiazide-induced hypokalaemia or hypomagnesaemia may occur as undesirable effects, favouring the onset of digitalis-induced cardiac arrhythmias.
Slovenian: Lahko pride do pojava s tiazidi inducirane hipokaliemije ali hipomagneziemije - neželenih učinkov, ki povečujeta verjetnost za nastop srčnih aritmij, ki jih povzroča digitalis.
English: Caution should be used with: alcohol, sleeping pills and anaesthetics (medicines allowing patients to undergo surgery and other procedures); amantadine (anti-Parkinson therapy, also used to treat or prevent certain illnesses caused by viruses); anticholinergic agents (medicines used to treat a variety of disorders such as gastrointestinal cramps, urinary bladder spasm, asthma, motion sickness, muscular spasms, Parkinson's disease and as an aid to anaesthesia); anticonvulsant medicines and mood-stabilising medicines used to treat epilepsy and bipolar disorder (e.g. carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone); cholestyramine, colestipol or other resins (substances used mainly to treat high levels of lipids in the blood); simvastatin (a medicine used to control high cholesterol levels); ciclosporin (a medicine used in transplantation to prevent organ rejection or for other conditions, e.g: rheumatoid arthritis or atopic dermatitis); cytotoxic medicines (used to treat cancer), such as methotrexate or cyclophosphamide; digoxin or other digitalis glycosides (medicines used to treat heart problems); verapamil, diltiazem (heart medicines);
Slovenian: Previdnost je potrebna pri uporabi: alkohola, uspavalnih tablet in anestetikov (zdravil, ki omogočajo bolnikom, da prestanejo operacije in druge posege); amantadina (zdravilo za zdravljenje Parkinsonove bolezni, ki ga uporabljamo tudi pri zdravljenju ali preprečevanju določenih bolezni, ki jih povzročajo virusi); antiholinergičnih zdravil (zdravil za zdravljenje različnih motenj, kot so želodčne in črevesne kolike, krči sečnega mehurja, astma, potovalna bolezen, mišični krči, Parkinsonova bolezen in kot dodatek pri anesteziji); antikonvulzivnih zdravil in stabilizatorjev razpoloženja, ki jih uporabljamo pri zdravljenju epilepsije in bipolarne motnje razpoloženja (npr. karbamazepina, fenobarbitala, fenitoina, fosfenitoina, primidona); holestiramina, holestipola ali drugih izmenjevalnih smol (snovi, ki jih uporabljamo predvsem za zdravljenje visokih ravni lipidov v krvi); simvastatin (zdravilo za uravnavanje previsoke ravni holesterola); ciklosporina (zdravila, ki ga uporabljamo pri presaditvah za preprečevanje zavrnitve presajenega organa ali pri drugih boleznih, npr. pri revmatoidnem artritisu ali atopijskem dermatitisu); citotoksičnih zdravil (za zdravljenje raka), kot sta metotreksat ali ciklofosfamid; digoksin ali druge glikozide digitalisa (zdravila za zdravljenje težav s srcem); verapamil, diltiazem (zdravili za srce); jodiranih kontrastnih sredstev (sredstev, ki jih uporabljajo pri slikovnih preiskavah); zdravila za zdravljenje sladkorne bolezni (peroralnih zdravil, kot je metformin, ali insulini); zdravil za zdravljenje protina, na primer alopurinola; zdravil, ki lahko zvišajo raven sladkorja v krvi (zaviralce adrenergičnih receptorjev beta, diazoksid);
English: Ion exchange resins
Slovenian: ionske izmenjevalne smole
English: If hypokalaemia develops during hydrochlorothiazide therapy, Imprida HCT should be discontinued until stable correction of the potassium balance.
Slovenian: Če se hipokaliemija pojavi v času zdravljenja s hidroklorotiazidom, je treba uporabo zdravila Imprida HCT prekiniti, dokler ni ravnovesje kalija stabilno.
English: Manufacturer Novartis Pharma GmbH Roonstraße 25
Slovenian: Novartis Pharma GmbH Roonstraße 25
English: Absorption: Following oral administration of valsartan alone, peak plasma concentrations of valsartan are reached in 2-4 hours.
Slovenian: Absorpcija: Po peroralni uporabi samega valsartana ta doseže največjo koncentracijo v plazmi v 2 do 4 urah.
English: Patients with mild to moderate renal impairment may therefore receive the usual initial dose (see sections 4.2 and 4.4).
Slovenian: Iz tega razloga lahko bolniki z blago do zmerno okvaro ledvic prejemajo običajne začetne odmerke (glejte poglavji 4.2 in 4.4).
English: Thiazides, including hydrochlorothiazide, may reduce the renal excretion of cytotoxic agents (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Slovenian: Tiazidi, vključno s hidroklorotiazidom, lahko zmanjšajo izločanje citotoksičnih zdravilnih učinkovin (npr. ciklofosfamida in metotreksata) preko ledvic in stopnjujejo njihov mielosupresiven učinek.
English: Hydrochlorothiazide
Slovenian: Hidroklorotiazid
English: Amlodipine should be used with caution together with CYP3A4 inducers.
Slovenian: Pri sočasni uporabi amlodipina in induktorjev CYP3A4 je potrebna previdnost.
English: Absorption: After oral administration of therapeutic doses of amlodipine alone, peak plasma concentrations of amlodipine are reached in 6-12 hours.
Slovenian: Absorpcija: Po peroralni uporabi terapevtskih odmerkov samega amlodipina ta doseže največjo koncentracijo v plazmi v 6 do 12 urah.
English: Hydrochlorothiazide, a sulphonamide, has been associated with an idiosyncratic reaction resulting in acute transient myopia and acute angle-closure glaucoma.
Slovenian: Hidroklorotiazid je sulfonamid, ki je povezan z idiosinkratično reakcijo, ki povzroča akutno prehodno kratkovidnost in akutni glavkom zaprtega zakotja.
English: The maximum recommended dose of Imprida HCT is 10 mg/320 mg/25 mg.
Slovenian: Najvišji priporočeni odmerek zdravila Imprida HCT je 10 mg/320 mg/25 mg.
English: • weakness, bruising, fever and frequent infections
Slovenian: • oslabelost, podplutbe, zvišana telesna temperatura in pogoste okužbe
English: It may be necessary to check the amount of potassium in your blood at regular intervals.
Slovenian: Verjetno bodo potrebne redne kontrolne meritve količine kalija v vaši krvi.
English: As expected for a compound where renal clearance accounts for only 30% of total plasma clearance, no correlation was seen between renal function and systemic exposure to valsartan.
Slovenian: To je tudi pričakovano pri spojini, pri kateri ledvični očistek predstavlja le 30 % celotnega očistka iz plazme.
English: Serum levels of calcium should be periodically monitored during treatment with thiazides.
Slovenian: V času zdravljenja s tiazidi je treba periodično spremljati koncentracijo kalcija v serumu.
English: 56 x 1 film-coated tablet (unit dose) 90 film-coated tablets
Slovenian: 56 x 1 filmsko obložena tableta (za enkratni odmerek) 90 filmsko obloženih tablet
English: • increase of urea nitrogen, creatinine and uric acid in the blood
Slovenian: • zvišana raven dušika iz sečne kisline, kreatinina in sečne kisline v krvi
English: Non-steroidal antiinflammatory medicines (NSAIDs), including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors), acetylsalicylic acid (>3 g/day), and nonselective NSAIDs
Slovenian: valsartan in hidroklorotiazid nesteroidna protivnetna zdravila (NSAIDs), vključno s selektivnimi zaviralci ciklooksigenaze-2 (z zaviralci COX-2), acetilsalicilno kislino (>3 g/dan) in neselektivnimi NSAIDs
English: • palpitations
Slovenian: • palpitacije
English: • skin reaction with skin reddening and peeling, blistering of lips, eyes or mouth
Slovenian: • kožna reakcija z rdečino in luščenjem kože, mehurjastim izpuščajem na ustnicah, očeh ali v ustih
English: However, staggering the dosage of hydrochlorothiazide and resin such that hydrochlorothiazide is administered at least 4 hours before or 4-6 hours after the administration of resins would potentially minimise the interaction.
Slovenian: Navedeno medsebojno delovanje pa je mogoče zmanjšati z ustreznim razporedom odmerjanja hidroklorotiazida in izmenjevalne smole, in sicer je treba hidroklorotiazid vzeti najmanj 4 ure pred odmerjanjem izmenjevalne smole oziroma 4-6 ur po njem.
English: Elimination: Hydrochlorothiazide is eliminated from plasma with a half-life averaging 6 to 15 hours in the terminal elimination phase.
Slovenian: Izločanje: V terminalni fazi izločanja se hidroklorotiazid iz plazme izloča z razpolovnim časom povprečno 6 do 15 ur.
English: Preclinical safety studies of up to 13 weeks in duration were conducted with amlodipine/valsartan/hydrochlorothiazide in rats.
Slovenian: Na podganah so izvajali predklinične študije varnosti s kombinacijo amlodipin/valsartan/hidroklorotiazid, ki so trajale do 13 tednov.