FrancophonIA/ELRC3.0 huggingface dataset:
English: The median time to progression (TTP) based on investigator-determined progressive disease (PD) was 7.5 months in the epoetin alfa plus SOC group and 7.5 months in the SOC group (HR 1.099, 95% CI: 0.998, 1.210).
Croatian: Medijan vremena do progresije, temeljen na ispitivačevoj ocjeni progresivne bolesti, iznosio je 7,5 mjeseci u skupini liječenoj epoetinom alfa i standardnom terapijom i 7,5 mjeseci u skupini liječenoj samo standardnom terapijom (HR 1,099, 95% CI: 0,998; 1,210).
English: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be life-threatening or fatal, have been reported in association with epoetin treatment (see section 4.4).
Croatian: Teške kožne nuspojave (SCAR) uključujući Stevens-Johnsonov sindrom (SJS) i toksičnu epidermalnu nekrolizu (TEN), koje mogu biti opasne po život ili smrtonosne, zabilježene su povezano s terapijom epoetinom (vidjeti dio 4.4).
English: Multipacks contain 4 (4 x 1) or 6 (6 x 1) pre-filled syringes.
Croatian: Višestruko pakiranje sadrži 4 (4 x 1) ili 6 (6 x 1) napunjenih štrcaljki.
English: Chronic renal failure patients being treated with epoetin zeta should have haemoglobin levels measured on a regular basis until a stable level is achieved, and periodically thereafter.
Croatian: Bolesnicima s kroničnim zatajenjem bubrega liječenim epoetinom zeta treba redovito mjeriti razinu hemoglobina sve do postizanja stabilne razine, a nakon toga povremeno.
English: The starting dose is 50 IU/kg, 2 times per week.
Croatian: Početna doza iznosi 50 IU/kg, 2 puta tjedno.
English: Retacrit is indicated in adults receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy) for the treatment of anaemia and reduction of transfusion requirements.
Croatian: Retacrit je indiciran za liječenje anemije i smanjenje potrebe za transfuzijom u odraslih koji primaju kemoterapiju zbog solidnih tumora, malignih limfoma ili multiplog mijeloma, a kod kojih postoji rizik od transfuzije prema procjeni općeg stanja bolesnika (npr. kardiovaskularni status, anemija prisutna prije početka kemoterapije).
English: If after an additional 4 weeks of therapy at 300 IU/kg 3 times per week, the haemoglobin concentration has increased ≥ 1 g/dL (≥0.62 mmol/L) or the reticulocyte count has increased ≥40 000 cells/µl, the dose should remain at 300 IU/kg 3 times per week.
Croatian: Ako se nakon dodatna 4 tjedna liječenja dozom od 300 IU/kg 3 puta tjedno koncentracija hemoglobina povećala za ≥ 1 g/dl (≥ 0,62 mmol/l), ili se broj retikulocita povećao za ≥ 40 000 stanica/µl iznad početne vrijednosti, dozu treba zadržati na 300 IU/kg, 3 puta tjedno.
English: Erythropoietin is a growth factor that primarily stimulates red cell production.
Croatian: Eritropoetin je čimbenik rasta koji prvenstveno potiče proizvodnju crvenih krvnih stanica.
English: Cancer patients being treated with epoetin zeta should have haemoglobin levels measured on a regular basis until a stable level is achieved, and periodically thereafter.
Croatian: U onkoloških bolesnika liječenih epoetinom zeta potrebno je redovito mjeriti razinu hemoglobina sve dok se ne postigne stabilna razina, a zatim povremeno.
English: Before use, leave the Retacrit syringe to stand until it reaches room temperature.
Croatian: Prije primjene, Retacrit štrcaljku treba ostaviti izvan hladnjaka da dosegne sobnu temperaturu.
English: Description of selected adverse reactions
Croatian: Opis određenih nuspojava
English: A rise in haemoglobin of greater than 2 g/dL (1.25 mmol/L) over a four week period should be avoided.
Croatian: Porast hemoglobina za više od 2 g/dl (1,25 mmol/l) tijekom četverotjednog razdoblja treba izbjegavati.
English: A slower administration is preferable in patients who react to the treatment with “flu-like” symptoms (see section 4.8).
Croatian: U bolesnika koji na terapiju reagiraju pojavom simptoma nalik gripi, preferira se sporija primjena (vidjeti dio 4.8).
English: No other ESA therapy should be commenced because of the risk of cross-reaction.
Croatian: Zbog rizika od križne reakcije ne smije se započeti terapija niti jednim drugim ESA lijekom.
English: Instructions on how to inject Retacrit yourself
Croatian: Upute za samostalnu primjenu injekcije Retacrita
English: In the 16-week study (n=222), in the epoetin alfa-treated patients there was no statistically significant effect on patient-reported or parent-reported Paediatric Quality of Life Inventory or Cancer Module scores compared with placebo (primary efficacy endpoint).
Croatian: U 16-tjednom ispitivanju (n = 222), prema samoprocjeni bolesnika ili procjeni roditelja bolesnika, liječenje epoetinom alfa nije imalo statistički značajan učinak na rezultate upitnika za procjenu kvalitete života pedijatrijskih bolesnika (engl.
English: - The active substance is epoetin zeta (produced by recombinant DNA technology in Chinese
Croatian: - Djelatna tvar je epoetin zeta (proizveden tehnologijom rekombinantne DNK na staničnoj liniji jajnika kineskog hrčka, engl.
English: • Serious skin reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported in association with epoetin treatment.
Croatian: • Zabilježene su ozbiljne kožne reakcije, uključujući Stevens-Johnsonov sindrom (SJS) i toksičnu epidermalnu nekrolizu (TEN) povezane s liječenjem epoetinom.
English: Epoetin zeta should be used with caution in nursing women.
Croatian: Epoetin zeta treba u dojilja primjenjivati s oprezom.
English: For patients in an autologous predonation programme, iron supplementation (elemental iron 200 mg/day orally) should be administered several weeks prior to initiating the autologous predeposit in order to achieve high iron stores prior to starting epoetin zeta therapy, and throughout the course of epoetin zeta therapy.
Croatian: u bolesnika u programu predonacije autologne krvi, nadoknadu željeza (elementarno željezo 200 mg na dan, peroralno) treba provesti nekoliko tjedana prije započinjanja pohrane autologne krvi, kako bi se osigurale velike zalihe željeza prije početka terapije epoetinom zeta te tijekom čitavog ciklusa terapije epoetinom zeta u bolesnika predviđenih za veliki elektivni ortopedski kirurški zahvat, nadoknadu željeza (elementarno željezo 200 mg na dan, peroralno) treba provoditi tijekom čitavog ciklusa terapije epoetinom zeta.
English: Adult haemodialysis patients
Croatian: Odrasli bolesnici na hemodijalizi
English: In cancer patients receiving chemotherapy, the 2 to 3 week delay between ESA administration and the appearance of erythropoietin-induced red cells should be taken into account when assessing if epoetin zeta therapy is appropriate (patient at risk of being transfused).
Croatian: Kada se u onkoloških bolesnika koji primaju kemoterapiju procjenjuje je li terapija epoetinom zeta za njih prikladna (bolesnici za koje pri transfuziji postoji rizik) treba uzeti u obzir vremenski razmak od 2 do 3 tjedna između primjene primjene ESA lijekova i pojave crvenih krvnih stanica induciranih eritropoetinom.
English: • Take the cover off the syringe by holding the barrel and pulling the cover off carefully without twisting it. Don't push the plunger, touch the needle or shake the syringe.
Croatian: • Skinite pokrov sa štrcaljke držeći cijev i pažljivo skidajući pokrov bez okretanja.
English: Epoetin alfa was evaluated in an open-label, non-randomised, open dose-range, 52-week clinical study in paediatric CRF patients undergoing haemodialysis.
Croatian: Epoetin alfa ocijenjen je u 52-tjednom otvorenom, nerandomiziranom kliničkom ispitivanju s otvorenim rasponom doza, provedenim u pedijatrijskih bolesnika s kroničnim zatajenjem bubrega podvrgnutih hemodijalizi.
English: Hypertension, Venous and arterial thrombosis
Croatian: Krvožilni poremećaji hipertenzija, venske i arterijske tromboze često hipertenzivne krize nepoznato
English: Your doctor will monitor your blood pressure regularly while you are using Retacrit.
Croatian: Dok primate Retacrit, liječnik će Vam redovito nadzirati krvni tlak.
English: You may have chest pain, breathlessness, and painful swelling and redness, usually in the leg as symptoms.
Croatian: Simptomi koje možete osjećati su bol u prsnom košu, nedostatak zraka te bolni otok i crvenilo, obično u nogama.
English: Epoetin alfa has been shown to stimulate erythropoiesis in anaemic patients with CRF, including dialysis and pre-dialysis patients.
Croatian: Pokazalo se da epoetin alfa potiče eritropoezu u anemičnih bolesnika s kroničnim zatajenjem bubrega, uključujući bolesnike na dijalizi i one koji još nisu na dijalizi.
English: Anaemia symptoms and sequelae may vary with age, gender, and co-morbid medical conditions; a physician's evaluation of the individual patient's clinical course and condition is necessary.
Croatian: Simptomi anemije i njezine posljedice mogu se razlikovati ovisno o dobi, spolu i komorbiditetnim medicinskim stanjima; potrebna je liječnička procjena kliničkog tijeka bolesti i stanja pojedinog bolesnika.
English: • Dispose of your used syringe in a sharps container.
Croatian: • Zbrinite štrcaljku u spremnik za oštre predmete.
English: If the patient has developed a severe cutaneous skin reaction such as SJS or TEN due to the use of Retacrit, treatment with Retacrit must not be restarted in this patient at any time.
Croatian: Ako je zbog primjene Retacrita bolesnik razvio tešku kožnu reakciju kao što je Stevens-Johnsonov sindrom ili toksična epidermalna nekroliza, ni u jednom trenutku ne smije se ponovno započeti liječenje tog bolesnika lijekom Retacrit.
English: Paediatric population with chronic renal failure on haemodialysis
Croatian: Pedijatrijska populacija s kroničnim zatajenjem bubrega na hemodijalizi
English: Pure Red Cell Aplasia (PRCA)
Croatian: Izolirana aplazija crvene krvne loze (eng.
English: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be life-threatening or fatal, have been reported in association with epoetin treatment.
Croatian: Teške kožne nuspojave (engl. severe cutaneous adverse reactions, SCAR) uključujući Stevens-Johnsonov sindrom (SJS) i toksičnu epidermalnu nekrolizu (TEN), koje mogu biti opasne po život ili smrtonosne, prijavljene su u povezanosti s terapijom epoetinom.
English: Epoetins are growth factors that primarily stimulate red blood cell (RBC) production.
Croatian: Epoetini su čimbenici rasta koji prvenstveno potiču proizvodnju crvenih krvnih stanica.
English: Retacrit should be administered to patients with anaemia (e.g. haemoglobin concentration ≤ 10 g/dL [6.2 mmol/L]).
Croatian: Retacrit treba primijeniti u bolesnika s anemijom (npr. koncentracija hemoglobina ≤ 10 g/dl [6,2 mmol/l]).
English: See section 4.
Croatian: Oogledajte dio 4.
English: This medicine contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially ‘sodium-free'.
Croatian: Ovaj lijek sadrži manje od 1 mmol natrija (23 mg) po dozi, tj. zanemarive količine natrija.
English: The starting dose is 50 IU/kg, 3 times per week.
Croatian: Početna doza iznosi 50 IU/kg, 3 puta tjedno.
English: If the haemoglobin concentration is increasing by more than 2 g/dL (1.25 mmol/L) per month, or if the haemoglobin concentration level exceeds 12 g/dL (7.5 mmol/L), reduce the Retacrit dose by about 25 to 50%.
Croatian: Ako se koncentracija hemoglobina povećava za više od 2 g/dl (1,25 mmol/l) mjesečno ili ako koncentracija hemoglobina prijeđe 12 g/dl (7,5 mmol/l), potrebno je smanjiti dozu Retacrita za približno 25% do 50%.
English: Early shunt revision and thrombosis prophylaxis by administration of acetylsalicylic acid, for example, is recommended in these patients.
Croatian: U takvih bolesnika preporučuje se rana korekcija šanta i profilaksa tromboze primjenom, primjerice, acetilsalicilatne kiseline.
English: An inverse relationship between apparent clearance and dose was noted in healthy subjects.
Croatian: Između prividnog klirensa i doze, u zdravih je ispitanika uočen obrnuti odnos.
English: Appropriate adjustment of the dose should be made in order to maintain haemoglobin levels within the desired concentration range between 9.5 g/dL to 11 g/dL (5.9 to 6.8 mmol/L).
Croatian: Potrebno je provesti odgovarajuću prilagodbu doze radi održavanja razine hemoglobina unutar željenog raspona koncentracije, između 9,5 g/dl i 11 g/dl (5,9 - 6,8 mmol/l).
English: From pretreatment to presurgery, the mean increase in haemoglobin in the 600 IU/kg weekly group (1.44 g/dL) was twice than that observed in the 300 IU/kg daily group (0.73 g/dL).
Croatian: Srednja vrijednost porasta razine hemoglobina od vrijednosti prije liječenja do one prije kirurškog zahvata bila je dvostruko veća u skupini koja je primala epoetin alfa u dozi od 600 IU/kg tjedno (1,44 /dl) nego u skupini koja je primala epoetin alfa u dozi od 300 IU/kg dnevno (0,73 g/dl).
English: The mean CL/F for the 150 IU/kg 3 times-per-week and 40 000 IU once-weekly regimens in healthy subjects were 31.2 and 12.6 mL/h/kg, respectively.
Croatian: Srednja vrijednost prividnog oralnog klirensa (CL/F) u zdravih ispitanika za režim doziranja od 150 IU/kg 3 puta tjedno bila je 31,2 ml/h/kg, a 12,6 ml/h/kg za režim doziranja od 40 000 IU jednom tjedno.
English: 1 pre-filled syringe without needle guard containing 0.75 ml solution for injection Component of a multipack, not to be sold separately.
Croatian: 1 napunjena štrcaljka bez štitnika za iglu s 0,75 ml otopine za injekciju Pojedine dijelove multipakiranja ne prodavati zasebno.
English: Retacrit should be administered to patients with symptomatic anaemia (e.g. haemoglobin concentration ≤10 g/dL (6.2 mmol/L)).
Croatian: Retacrit se primjenjuje u bolesnika sa simptomatskom anemijom (npr. koncentracija hemoglobina ≤ 10 g/dl (6,2 mmol/l)).
English: In chronic renal failure patients, the half-life of intravenously administered erythropoietin is slightly prolonged, approximately 5 hours, compared to healthy subjects.
Croatian: U usporedbi sa zdravim ispitanicima, u bolesnika s kroničnim zatajenjem bubrega poluvijek intravenski primijenjenog eritropetina blago je produljen, približno 5 sati.
English: Hypertensive crisis with encephalopathy and seizures, requiring the immediate attention of a physician and intensive medical care, have occurred also during epoetin zeta treatment in patients with previously normal or low blood pressure.
Croatian: Tijekom liječenja epoetinom zeta u bolesnika s prethodno normalnim ili niskim krvnim tlakom pojavile su se i hipertenzivne krize s encefalopatijom i napadajima, koje zahtijevaju hitnu liječničku pomoć i intenzivnu medicinsku skrb.
English: 1 pre-filled syringe without needle guard containing 1 ml solution for injection Component of a multipack, not to be sold separately.
Croatian: 1 napunjena štrcaljka bez štitnika za iglu s 1 ml otopine za injekciju Pojedine dijelove multipakiranja ne prodavati zasebno.
English: 1 pre-filled syringe without needle guard containing 0.5 ml solution for injection Component of a multipack, not to be sold separately.
Croatian: 1 napunjena štrcaljka bez štitnika za iglu s 0,5 ml otopine za injekciju Sastavni dio višestrukog pakiranja, ne prodavati zasebno.
English: Yes ≤2 RBC Units ˃2 and ≤4 RBC Units ˃4 RBC Units No one subject did not have sEPO data in the ≥200 mU/ml stratum there were 13 subjects in the epoetin alfa group and 6 subjects in the placebo group
Croatian: Ne jedan ispitanik nije imao podatke za sEPO u sloju s vrijednostima ≥ 200 mU/ml 13 ispitanika bilo je u skupini koja je primala epoetin alfa, a 6 ispitanika u skupini koja je primala placebo
English: In paediatric patients with chronic renal failure where intravenous access is routinely available (haemodialysis patients) administration of Retacrit by the intravenous route is preferable.
Croatian: U pedijatrijskih bolesnika s kroničnim zatajenjem bubrega u kojih je intravenski put rutinski dostupan (bolesnici na hemodijalizi) preferira se primjena Retacrita intravenskim putem.
English: Epoetin zeta should be withheld when the haemoglobin concentration exceeds 12 g/dL (7.5 mmol/L).
Croatian: Primjenu epoetina zeta treba prekinuti kada koncentracija hemoglobina premaši 12 g/dl (7,5 mmol/l).
English: If the haemoglobin exceeds 13 g/dL (8.1 mmol/L), discontinue therapy until it falls below 12 g/dL (7.5 mmol/L) and then reinstitute Retacrit therapy at a dose 25% below the previous dose.
Croatian: Ako razina hemoglobina prijeđe 13 g/dl (8,1 mmol/l), terapiju treba prekinuti dok se vrijednost ne smanji ispod 12 g/dl (7,5 mmol/l), a zatim ponovno uvesti terapiju Retacritom u dozi koja je za 25% niža od prethodne doze.
English: The symptoms are: o unusual tiredness, o feeling dizzy, o breathlessness.
Croatian: Simptomi su: o neuobičajen umor o osjećaj omaglice o nedostatak zraka.
English: • The starting dose is 450 IU per kilogram bodyweight once a week.
Croatian: Početna doza iznosi 450 IU po kilogramu tjelesne težine jednom tjedno.
English: Treatment of adult patients with chemotherapy-induced anaemia
Croatian: Liječenje odraslih bolesnika s anemijom uzrokovanom kemoterapijom
English: Multipack: 6 (6 x 1) pre-filled syringes.
Croatian: Višestruko pakiranje: 6 (6 x 1) napunjenih štrcaljki.
English: If the haemoglobin concentration has increased by at least 1 g/dL (0.62 mmol/L) or the reticulocyte count has increased ≥ 40 000 cells/µL above baseline after 4 weeks of treatment, the dose should remain at 150 IU/kg 3 times per week or 450 IU/kg once weekly.
Croatian: Ako se nakon 4 tjedna liječenja koncentracija hemoglobina povećala za najmanje 1 g/dl (0,62 mmol/l) ili se broj retikulocita povećao za ≥ 40 000 stanica/µl iznad početne vrijednosti, treba nastaviti s primjenom doze od 150 IU/kg 3 puta tjedno ili 450 IU/kg jednom tjedno.
English: PRCA has been very rarely reported mostly in patients with kidney disease after months to years of treatment with Retacrit and other products that stimulate red blood cell production.
Croatian: U bolesnika s bolešću bubrega, nakon mjeseci do godina liječenja Retacritom i drugim lijekovima koji stimuliraju proizvodnju crvenih krvnih stanica, izolirana aplazija crvene krvne loze prijavljena je vrlo rijetko.
English: Each pre-filled syringe contains 1 ml solution.
Croatian: Jedna napunjena štrcaljka sadrži 1 ml otopine.
English: The solution contains 40 000 IU epoetin zeta per ml.
Croatian: Otopina sadrži 40 000 IU epoetina zeta po ml.
English: The solution contains 10 000 IU epoetin zeta per ml.
Croatian: Otopina sadrži 10 000 IU epoetina zeta po ml.
English: The recommended desired haemoglobin concentration range is between 10 g/dL to 12 g/dL (6.2 to 7.5 mmol/L).
Croatian: Preporučeni željeni raspon koncentracije hemoglobina iznosi između 10 g/dl i 12 g/dl (6,2 7,5 mmol/l).
English: If the haemoglobin concentration level exceeds 13 g/dL (8.1 mmol/L), discontinue therapy until it falls below 12 g/dL (7.5 mmol/L) and then reinitiate Retacrit therapy at a dose 25% below the previous dose.
Croatian: Ako koncentracija hemoglobina prijeđe 13 g/dl (8,1 mmol/l), terapiju treba prekinuti dok se koncentracija hemoglobina ne spusti ispod 12 g/dl (7,5 mmol/l), a zatim ponovno uvesti terapiju Retacritom u dozi koja je za 25% niža od prethodne doze.
English: In patients with chronic renal failure where intravenous access is routinely available (haemodialysis patients) administration of Retacrit by the intravenous route is preferable.
Croatian: U bolesnika s kroničnim zatajenjem bubrega u kojih je intravenski put rutinski dostupan (bolesnici na hemodijalizi), preferira se primjena Retacrita intravenskim putem.
English: Cytotoxic actions of epoetin alfa on bone marrow cells could not be detected.
Croatian: Nije zapaženo citotoksično djelovanje epoetina alfa na stanice koštane srži.
English: The safety of epoetin zeta has not been established in patients with hepatic dysfunction.
Croatian: Sigurnost primjene epoetina zeta u bolesnika s oštećenjem funkcije jetre nije ustanovljena.
English: Treatment of adult patients scheduled for major elective orthopaedic surgery
Croatian: Liječenje odraslih bolesnika planiranih za veliki elektivni ortopedski kirurški zahvat
English: Chronic renal failure
Croatian: Kronično zatajenje bubrega
English: In paediatric patients on haemodialysis where intravenous access is readily available, administration by the intravenous route is preferable.
Croatian: U pedijatrijskih bolesnika na hemodijalizi u kojih je intravenski pristup lako dostupan, preferira se primjena intravenskim putem.
English: Treatment of symptomatic anaemia in adult and paediatric chronic renal failure patients
Croatian: Liječenje simptomatske anemije u odraslih i pedijatrijskih bolesnika s kroničnim zatajenjem bubrega
English: If the haemoglobin is rising by more than 2 g/dL (1.25 mmol/L) per month, or if the sustained haemoglobin exceeds 12 g/dL (7.5 mmol/L) reduce the Retracrit dose by 25%.
Croatian: Ako je porast vrijednosti hemoglobina veći od 2 g/dl (1,25 mmol/l) mjesečno ili ako razina hemoglobina kontinuirano prelazi 12 g/dl (7,5 mmol/l), dozu Retacrita treba smanjiti za 25%.
English: Anaemia in chronic renal failure patients before initiation of dialysis or on peritoneal dialysis
Croatian: Anemija u bolesnika s kroničnim zatajenjem bubrega koji još nisu na dijalizi ili su na peritonejskoj dijalizi
English: • The usual starting dose of Retacrit for adults and children is 50 International Units (IU) per kilogram (/kg) of body weight given three times a week.
Croatian: • Uobičajena početna doza Retacrita za odrasle i djecu iznosi 50 međunarodnih jedinica (skraćeno IU prema engl.
English: Treatment of paediatric patients with chemotherapy-induced anaemia
Croatian: Liječenje pedijatrijskih bolesnika s anemijom uzrokovanom kemoterapijom
English: Retacrit 8 000 IU/0.8 ml solution for injection in pre-filled syringe 1 pre-filled syringe with 0.8 ml solution for injection contains 8 000 international units (IU) epoetin zeta* (recombinant human erythropoietin).
Croatian: Retacrit 8000 IU/0,8 ml otopina za injekciju u napunjenoj štrcaljki 1 napunjena štrcaljka s 0,8 ml otopine za injekciju sadrži 8000 internacionalnih jedinica (IU) epoetina zeta* (rekombinantni humani eritropoetin).
English: Multipacks contain 4 (4 x 1) pre-filled syringes.
Croatian: Višestruko pakiranje sadrži 4 (4 x 1) napunjene štrcaljke.
English: Mean haemoglobin levels were similar for the two treatment groups throughout the postsurgical period.
Croatian: Tijekom cijelog razdoblja poslije kirurškog zahvata, srednja vrijednost razina hemoglobina bila je slična u obje skupine.
English: • Symptoms of pure red cell aplasia (PRCA)
Croatian: • simptomi izolirane aplazije crvene krvne loze
English: SJS/TEN can appear initially as reddish target-like spots or circular patches often with central blisters on the trunk.
Croatian: Stevens-Johnsonov sindrom i toksična epidermalna nekroliza mogu se najprije pojaviti u obliku crvenkastih mrlja nalik na metu ili u obliku okruglih područja, često sa središnjim mjehurićima na trupu.
English: Patients scheduled for major elective orthopaedic surgery should receive adequate antithrombotic prophylaxis, as thrombotic and vascular events may occur in surgical patients, especially in those with underlying cardiovascular disease.
Croatian: S obzirom da u kirurških bolesnika može doći do pojave trombotičkih i vaskularnih događaja, posebno u onih s pratećim kardiovaskularnim bolestima, bolesnici u kojih se planira veliki elektivni ortopedski kirurški zahvat trebaju primiti adekvatnu antitrombotičku profilaksu.
English: A haemoglobin concentration of greater than 12 g/dL (7.5 mmol/L) should be avoided.
Croatian: Koncentraciju hemoglobina veću od 12 g/dl (7,5 mmol/l) treba izbjegavati.
English: If the haemoglobin concentration increase is <1 g/dL (<0.62 mmol/L) and the reticulocyte count has increased <40 000 cells/µl above baseline, increase the dose to 300 IU/kg 3 times per week.
Croatian: Ako se koncentracija hemoglobina povećala za < 1 g/dl (< 0,62 mmol/l) ili se broj retikulocita povećao za < 40 000 stanica/µl iznad početne vrijednosti, dozu treba povisiti na 300 IU/kg, 3 puta tjedno.