FrancophonIA/ELRC3.0 huggingface dataset:
English: For patients with moderate renal impairment (CLcr ≥30 and
Croatian: Bolesnicima s blagim oštećenjem bubrega (CLcr ≥50 i
English: Common (may affect up to 1 in 10 people): • feeling sick, heartburn and discomfort in swallowing (inflammation of your gullet/ food pipe)
Croatian: Česte (mogu se javiti kod manje od 1 na 10 osoba): • mučnina, žgaravica i nelagoda pri gutanju (upala jednjaka)
English: Clinically relevant hypocalcaemia (very low serum calcium levels) should be corrected by intravenous administration of calcium gluconate.
Croatian: Klinički značajnu hipokalcijemiju (vrlo niske razine kalcija u serumu) potrebno je liječiti intravenskom primjenom kalcijevog glukonata.
English: If you have a raised calcium level in your blood due to a tumour then the recommended dose is a single administration of 2 ampoules (2 mg) or 4 ampoules (4 mg), depending on the severity of your illness.
Croatian: Ako imate povišenu razinu kalcija u krvi uzrokovanu tumorom, tada je preporučena doza jednokratna primjena 2 ampule (2 mg) ili 4 ampule (4 mg), ovisno o težini bolesti.
English: A repeated dose may be considered in case of insufficient response or if your illness reappears.
Croatian: U slučaju nedovoljnog odgovora ili ponovnog javljanja bolesti, može se razmotriti ponavljanje doze.
English: Talk to a nurse or a doctor straight away if you notice any of the following serious side effects, you may need urgent medical treatment:
Croatian: Odmah se obratite medicinskoj sestri ili liječniku ako primijetite bilo koju od sljedećih ozbiljnih nuspojava, možda će Vam biti potrebno hitno liječenje:
English: 2 mg (2 ml of concentrate for solution for infusion)
Croatian: 2 mg (2 ml koncentrata za otopinu za infuziju)
English: Hypromellose (E464) Titanium dioxide E171
Croatian: Ovojnica tablete: laktoza hidrat makrogol 4000 hipromeloza (E464) titanijev dioksid (E171)
English: This medicinal product does not require any special storage conditions prior to reconstitution.
Croatian: POSEBNE MJERE ČUVANJA Nema posebnih uvjeta čuvanja prije pripreme za primjenu.
English: Orally administered bisphosphonates may cause local irritation of the upper gastrointestinal mucosa.
Croatian: Gastrointestinalna iritacija Peroralno primijenjeni bisfosfonati mogu uzrokovati lokalnu iritaciju sluznice gornjeg dijela gastrointestinalnog sustava.
English: • high levels of urea or high levels of parathyroid hormone in your blood.
Croatian: • visoke razine ureje i visoke razine hormona paratiroidne žlijezde u krvi.
English: • flu-like symptoms, including fever, shaking and shivering, feeling of discomfort, fatigue, bone pain and aching muscles and joints.
Croatian: •• simptomi nalik gripi, uključujući vrućicu, tresavicu i drhtanje, osjećaj nelagode, umor, bol u kostima, mišićima i zglobovima.
English: - Patients should not lie down for 60 minutes after taking Iasibon.
Croatian: Nakon uzimanja lijeka Iasibon bolesnik ne smije leći sljedećih 60 minuta.
English: Data from this study demonstrated a significant advantage for intravenous Ibandronate 6 mg over placebo in the reduction in SREs measured by the time-adjusted SMPR (p=0.004).
Croatian: Podaci prikupljeni tijekom ovog ispitivanja pokazali su znatnu prednost ibandronata 6 mg danog intravenski, u odnosu na placebo u pogledu smanjivanja SRE, mjereno vremenski prilagođenim SMPR-om (p=0,004).
English: Tests for genotoxicity revealed no evidence of effects on genetic activity for ibandronic acid.
Croatian: U testovima genotoksičnosti nije bilo dokaza učinka ibandronatne kiseline na genetsku aktivnost.
English: Osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection (including osteomyelitis), has been reported in patients with cancer receiving treatment regimens including primarily intravenously administered bisphosphonates.
Croatian: Osteonekroza čeljusti, obično povezana s vađenjem zuba i/ili lokalnom infekcijom (uključujući osteomijelitis), primijećena je u bolesnika s rakom čije se liječenje prvenstveno zasnivalo na intravenskoj primjeni bisfosfonata.
English: Patients with renal impairment Exposure to ibandronic acid in patients with various degree of renal impairment is related to creatinine clearance (CLcr).
Croatian: Bolesnici s oštećenjem bubrega Izloženost ibandronatnoj kiselini u bolesnika s različitim stupnjevima oštećenja bubrega povezana je s klirensom kreatinina (CLcr).
English: = Serum calcium (mg/dl) + 0.8 x [4 - albumin (g/dl)]
Croatian: = kalcij u serumu (mg/dl) + 0,8 x [4 - albumin (g/dl)]
English: Not all pack sizes may be marketed
Croatian: Na tržištu se ne moraju nalaziti sve veličine pakiranja
English: You can drive and use machines as it's expected that Iasibon affectshas no or negligible effect on your ability to drive and use machines.
Croatian: Možete voziti i raditi sa strojevima jer se očekuje da Iasibon ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Patients with disturbances of bone and mineral metabolism Hypocalcaemia and other disturbances of bone and mineral metabolism should be effectively treated before starting Iasibon therapy for metastatic bone disease.
Croatian: Bolesnici s poremećajima metabolizma kosti i minerala Hipokalcijemiju i ostale poremećaje metabolizma kostiju i minerala potrebno je učinkovito izliječiti prije početka liječenja metastatske bolesti kostiju lijekom Iasibon.
English: • low calcium or phosphate levels in your blood
Croatian: • snižena razina kalcija ili fosfata u krvi
English: It is not known whether ibandronic acid is excreted in human milk.
Croatian: Nije poznato izlučuje li se ibandronatna kiselina u majčino mlijeko u ljudi.
English: The pain reduction was consistently below baseline throughout the entire study and accompanied by a significantly reduced use of analgesics.
Croatian: Smanjenje boli bilo je tijekom cjelokupnog ispitivanja ispod početne vrijednosti i praćeno značajno smanjenom primjenom analgetika.
English: Table 1 lists adverse reactions from 2 pivotal phase III studies (Prevention of skeletal events in patients with breast cancer and bone metastases: 286 patients treated with ibandronic acid 50 mg administered orally), and from post-marketing experience.
Croatian: Tablici 1 navedene su nuspojave iz 2 pivotalna ispitivanja faze III (Sprječavanje koštanih događaja u bolesnika s rakom dojke i koštanim metastazama: 286 bolesnika liječena ibandronatnom kiselinom od 50 mg primijenjenom peroralno) i iz iskustva nakon stavljanja lijeka na tržište.
English: Iasibon is used in adults and prescribed to you if you have breast cancer that has spread to your bones (called ‘bone metastases').
Croatian: Iasibon se koristi za lijiečenje odraslih bolesnika i biti će Vam propisan ako imate rak dojke koji se proširio na kosti (što se naziva „koštane metastaze“).
English: While no increased risk was observed in controlled clinical trials there have been post-marketing reports of gastric and duodenal ulcers with oral bisphosphonate use, some severe and with complications.
Croatian: Dok u kliničkim ispitivanjima nije primijećen povećani rizik, nakon stavljanja lijeka na tržište su, kod peroralne primjene bisfosfonata, prijavljeni vrijedovi želuca i dvanaesnika, od kojih su neki bili teški s komplikacijama.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Do not suck, chew or crush tablets Read the package leaflet before use Oral use
Croatian: NAČIN I PUT(EVI) PRIMJENE LIJEKA Ne cuclajte, ne žvačite i ne drobite tabletu Prije uporabe pročitati Uputu o lijeku
English: • pain or sore in your mouth or jaw.
Croatian: • bol ili ranica u ustima ili čeljusti.
English: Teл.
Croatian: dana.
English: Talk to a nurse or a doctor straight away if you notice any of the following serious side effectsyou may need urgent medical treatment:
Croatian: Odmah se obratite medicinskoj sestri ili liječniku ako primijetite bilo koju od sljedećih ozbiljnih nuspojava - možda će Vam biti potrebno hitno liječenje:
English: • fluid in your lungs
Croatian: • nakupljanje tekućine u plućima
English: Atypical subtrochanteric and diaphyseal femoral fractures have been reported with bisphosphonate therapy, primarily in patients receiving long-term treatment for osteoporosis.
Croatian: Atipične suptrohanterične dijafizealne frakture femura zabilježene su kod liječenja bisfosfonatima, prvenstveno u bolesnika koji su dugotrajno primali lijekove protiv osteoporoze.
English: This is because aminoglycosides and Iasibon can both lower the amount of calcium in your blood.
Croatian: To je važno stoga što i aminoglikozidi i Iasibon mogu smanjiti razinu kalcija u krvi.
English: Description of selected adverse reactions
Croatian: Opis odabranih nuspojava Hipokalcijemija
English: The median time to relapse was 26 days with a dose of 6 mg.
Croatian: Za dozu od 6 mg medijan vremena do pojave recidiva iznosio je 26 dana.
English: Possible side effects Like all medicines, this medicine can cause side effects although not everybody gets them.
Croatian: Moguće nuspojave Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave iako se one neće javiti kod svakoga.
English: • low calcium levels in your blood
Croatian: • snižena razina kalcija u krvi
English: Infection Cystitis, vaginitis, oral candidiasis
Croatian: Infekcije i infestacije infekcija cistitis, vaginitis, oralna kandidijaza
English: To avoid potential incompatibilities Iasibon concentrate for solution for infusion should only be diluted with isotonic sodium chloride solution or 5% glucose solution.
Croatian: Da bi se izbjegle potencijalne inkompatibilnosti, Iasibon koncentrat za otopinu za infuziju smije se razrijediti samo izotoničnom otopinom natrijevog klorida ili 5%-tnom otopinom glukoze.
English: There was also a 38% reduction in the risk of developing an SRE for Ibandronate treated patients when compared with placebo (relative risk 0.62, p=0.003).
Croatian: U usporedbi s placebo grupom, u bolesnika liječenih ibandronatom rizika od razvoja SRE bio je za 38% manji (relativni rizik 0,62; p=0,003).
English: Osteonecrosis of the external auditory canal has been reported with bisphosphonates, mainly in association with long-term therapy.
Croatian: Osteonekroza vanjskog slušnog kanala Osteonekroza vanjskog slušnog kanala prijavljena je s bisfosfonatima, uglavnom povezana s dugoročnom terapijom.
English: Therefore, it is recommended that the tablets should be taken after an overnight fast (at least 6 hours) and fasting should continue for at least 30 minutes after the dose has been taken (see section 4.2).
Croatian: Stoga se uzimanje tableta preporučuje natašte, nakon noćnog gladovanja (barem 6 sati), a hrana se ne smije uzimati najmanje još sljedećih 30 minuta nakon uzimanja doze (vidjeti dio
English: Myocardial ischaemia, cardiovascular disorder, palpitations
Croatian: Srčani poremećaji blok grane ishemija miokarda, kardiovaskularni poremećaj, palpitacije
English: The recommended dose for prevention of skeletal events in patients with breast cancer and bone metastases is 6 mg intravenous injection given every 3-4 weeks.
Croatian: Preporučena doza za prevenciju koštanih događaja u bolesnika s rakom dojke i koštanim metastazama iznosi 6 mg intravenskom injekcijom svaka 3 - 4 tjedna.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS Ampoule
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE Ampula
English: Iasibon works by reducing the amount of calcium that is lost from your bones.
Croatian: Iasibon djeluje tako da smanjuje gubitak kalcija iz kostiju.
English: This is because the medicine will only work if it is taken all the time.
Croatian: Uzimajte Iasibon tijekom čitavog razdoblja koje vam je propisao liječnik jer djeluje samo ako se uzima čitavo vrijeme.
English: • if you have any swallowing or digestion problems
Croatian: • ako imate problema s gutanjem ili probavom.
English: There was a marked depression of urinary markers of bone resorption (pyridinoline and deoxypyridinoline) in patients treated with Ibandronate that was statistically significant compared to placebo.
Croatian: U bolesnika liječenih ibandronatom došlo je do značajnog pada biljega resorpcije kostiju u urinu (piridinolin i deoksipiridinolin) koji je bio statistički značajan u usporedbi s placebo grupom.
English: (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Nepoznate učestalosti (učestalost se ne može odrediti na temelju dostupnih podataka)
English: • Do not use this medicine after the expiry date which is stated on the blister and carton after EXP.
Croatian: • Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na blisteru i kutiji iza kratice „EXP“ ili „Rok valjanosti“.
English: Nevertheless, according to clinical assessment of the individual patient, it is recommended that renal function, serum calcium, phosphate and magnesium should be monitored in patients treated with Iasibon .
Croatian: Unatoč tome, na temelju kliničke procjene za pojedinog bolesnika, preporučuje se praćenje bubrežne funkcije te kalcija, fosfata i magnezija u serumu, u bolesnika koji se liječe lijekom
English: White round biconvex tablets
Croatian: Bijele, okrugle, bikonveksne tablete
English: In reproductive studies in rats by the oral route, effects on fertility consisted of increased preimplantation losses at dose levels of 1 mg/kg/day and higher.
Croatian: U reproduktivnim ispitivanjima peroralne primjene na štakorima, djelovanje na plodnost obuhvaćalo je povećani gubitak prije implantacije pri dozama od 1 mg/kg na dan i višim.
English: After reconstitution: Store at 2°C - 8°C (in a refrigerator).
Croatian: Nakon rekonstitucije: čuvati na temperaturi od 2°C - 8°C (u hladnjaku).
English: • it is given as an infusion into your vein
Croatian: • Primit ćete ga u obliku infuzije u venu.
English: Clinical studies in patients with breast cancer and bone metastases have shown that there is a dose dependent inhibitory effect on bone osteolysis, expressed by markers of bone resorption, and a dose dependent effect on skeletal events.
Croatian: Klinička ispitivanja u bolesnika s rakom dojke i koštanim metastazama pokazala su da postoji inhibitorni učinak na osteolizu kostiju ovisan o dozi, izražen biljezima resorpcije kostiju te učinak na koštane promjene ovisan o dozi.
English: • fluid build up and swelling (‘lymphoedema')
Croatian: • nakupljanje tekućine i naticanje (“limfedem”)
English: What you need to know before you take Iasibon
Croatian: Što morate znati prije nego počnete uzimati Iasibon
English: Ocular inflammation Ocular inflammation events such as uveitis, episcleritis and scleritis have been reported with ibandronic acid.
Croatian: Događaji povezani s upalom oka poput uveitisa, episkleritisa ili skleritisa zabilježeni su uz primjenu ibandronatne kiseline.
English: Iasibon contains the active substance ibandronic acid.
Croatian: Iasibon sadrži djelatnu tvar ibandronatnu kiselinu.
English: Iasibon 50 mg film-coated tablets ibandronic acid
Croatian: Iasibon 50 mg filmom obložene tablete ibandronatna kiselina
English: Osteonecrosis of the external auditory canal
Croatian: osteonekroza vanjskog slušnog kanala (nuspojava razreda bisfosfonata)
English: • tablet core: povidone, microcrystalline cellulose, crospovidone, maize starch pregelatinised,
Croatian: • jezgra tablete: povidon, mikrokristalična celuloza, krospovidon, prethodno geliran kukuruzni škrob, gliceroldibehenat, koloidni bezvodni silicijev dioksid.
English: Iasibon contains less than 1 mmol sodium (23 mg) per ampoule, i.e. essentially sodium free.
Croatian: Iasibon sadrži manje od 1 mmol natrija (23 mg) po ampuli, odnosno bitno natrij besplatno.
English: For any information about this medicine, please contact the local representative of the Marketing
Croatian: Za sve informacije o ovom lijeku obratite se lokalnom predstavniku nositelja odobrenja za stavljanje gotovog lijeka u promet:
English: Do not receive this medicine if any of the above apply to you.
Croatian: Ako se bilo što od gore navedenog odnosi na Vas, ne smijete primiti ovaj lijek.
English: Table 3 Secondary efficacy results (breast cancer patients with metastatic bone disease)
Croatian: Tablica 3 Sekundarni rezultati djelotvornosti (bolesnici s rakom dojke i koštanim metastazama)
English: Cases of anaphylactic reaction/shock, including fatal events, have been reported in patients treated with intravenous ibandronic acid.
Croatian: Slučajevi anafilaktičke reakcije/šoka, uključujući događaje sa smrtnim ishodom, prijavljeni su u bolesnika liječenih intravenski ibandronatnom kiselinom.
English: Do not take this medicine if any of the above apply to you.
Croatian: Ako se bilo što od gore navedenog odnosi na Vas, ne smijete uzimati ovaj lijek.
English: Iasibon concentrate for solution for infusion should be administered as an intravenous infusion over 2 hours.
Croatian: Iasibon koncentrat za otopinu za infuziju mora se primijeniti intravenskom infuzijom u trajanju od 2 sata.
English: Metabolism and nutrition disorders
Croatian: Poremećaji metabolizma i prehrane hipokalcijemija*
English: Since both the kidney and the liver were found to be target organs for toxicity in preclinical studies with high doses, kidney and liver function should be monitored.
Croatian: Budući da je u pretkliničkim ispitivanjima pri visokim dozama ustanovljeno da su bubrezi i jetra ciljni organi za toksičnost, potrebno je pratiti funkcije jetre i bubrega.
English: PHARMACEUTICAL FORM AND CONTENTS Concentrate for solution for infusion.
Croatian: OBLIK I SADRŽAJ Koncentrat za otopinu za infuziju
English: • if you have kidney problems
Croatian: • ako imate problema s bubrezima
English: A 15 minute infusion time has not been studied in cancer patients with CLCr <50 mL/min.
Croatian: Nije provedeno ispitivanje 15-minutne infuzije u bolesnika oboljelih od raka s CLcr <50 ml/min.
English: Sleep disorder, anxiety, affection lability
Croatian: anksioznost, emocionalna labilnost
English: However, oral overdosage may result in upper gastrointestinal events, such as upset stomach, heartburn, oesophagitis, gastritis or ulcer.
Croatian: Predoziranje peroralnim putem može rezultirati poremećajima gornjeg dijela probavnog sustava, primjerice iritacijom želuca, žgaravicom, ezofagitisom, gastritisom ili vrijedom.
English: Patients with hepatic impairment
Croatian: Bolesnici s oštećenjem srca
English: Blood and lymphatic system disorders
Croatian: Poremećaj i krvi i limfnog sustava anemija
English: No systemic accumulation was observed when ibandronic acid was administered intravenously once every 4 weeks for 48 weeks to patients with metastatic bone disease.
Croatian: U bolesnika s koštanim metastazama nije zamijećeno sustavno akumuliranje pri intravenskoj primjeni ibandronatne kiseline svaka 4 tjedna u razdoblju od 48 tjedana.
English: Talk to your doctor first if you want to drive, use machines or tools.
Croatian: Želite li voziti, koristiti strojeve ili alate,
English: • your body temperature getting too low (‘hypothermia')
Croatian: • preniska tjelesna temperatura (hipotermija)
English: • a problem with your eyes called ‘cataracts'
Croatian: • problem s očima zvan očna mrena
English: • if you have high or low blood levels of vitamin D or any other minerals
Croatian: • ako imate visoke ili niske razine vitamina
English: *Mean change from baseline to last assessment.
Croatian: * Srednja vrijednost promjene od početne vrijednosti do zadnje procjene.
English: As no clinical data are available, dosage recommendations cannot be given for patients with severe hepatic insufficiency (see section 4.2)..
Croatian: Bolesnici s oštećenjem jetre Budući da nisu dostupni klinički podaci, ne mogu se dati preporuke za doziranje u bolesnika s teškom insuficijencijom jetre (vidjeti dio 4.2).
English: The primary endpoint of the trial was the skeletal morbidity period rate (SMPR).
Croatian: Primarna mjera ishoda ispitivanja bila je određivanje stope razdoblja s morbiditetom kostiju (SMPR; engl. skeletal morbidity period rate).
English: No dose adjustment is necessary (see section 5.2).
Croatian: Nije potrebna prilagodba doze (vidjeti dio 5.2).
English: The median time to relapse (return of albumin-corrected serum calcium to levels above 3 mmol/l) was 1819 days for the 2 mg and 4 mg doses.
Croatian: Medijan vremena do pojave recidiva (povratka vrijednosti kalcija u serumu korigiranih albuminom na razinu višu od 3 mmol/l) iznosio je 18 - 19 dana za doze od 2 mg i 4 mg.
English: Reproductive system and breast disorders
Croatian: Poremećaji reproduktivnog sustava i dojki bolovi u zdjelici
English: Iasibon 6mg is supplied as packs containing 1, 5 and 10 vials (9 ml type I glass vial with a bromobutyl rubber stopper).
Croatian: Iasibon 6 mg je dostupan u pakiranjima od 1, 5, 10 bočica (bočica od 9 ml, staklo tipa I, s čepom od bromobutilne gume).
English: Periodic safety update reports
Croatian: • Periodička izvješća o neškodljivosti
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 21 January 2011
Croatian: Datum prvog odobrenja: 21. siječanj 2011.
English: Ear and labyrinth disorders
Croatian: Poremećaji uha i labirinta gluhoća
English: Fractures are often bilateral; therefore the contralateral femur should be examined in bisphosphonate-treated patients who have sustained a femoral shaft fracture.
Croatian: Prijelomi su često bilateralni, stoga u bolesnika koji primaju bisfosfonate i koji su imali prijelom trupa bedrene kosti treba pregledati i bedrenu kost na suprotnoj nozi.
English: The safety and efficacy of Iasibon in children and adolescents below the age of 18 years have not been established.
Croatian: Sigurnost i djelotvornost lijeka Iasibon u djece i adolescenata mlađih od 18 godina nisu ustanovljene.
English: Prescribers should consult the section Patients with Renal Impairment (see section 4.2) for recommendations on dosing and administration in this patient group.
Croatian: Propisivači mogu pronaći preporuke za doziranje i primjenu u toj skupini bolesnika u odjeljku Bolesnici s oštećenjem bubrega (vidjeti dio 4.2).
English: Appropriate medical support and monitoring measures should be readily available when Iasibon intravenous injection is administered.
Croatian: Prilikom primjene intravenske injekcije lijeka Iasibon moraju biti dostupne odgovarajuća medicinska podrška i mjere nadzora.
English: • Treatment of tumour-induced hypercalcaemia - added to 500 ml isotonic sodium chloride solution or 500 ml 5% dextrose solution and infused over 2 hours
Croatian: • liječenje hiperkalcijemije nastale zbog tumora - treba ga dodati u 500 ml izotonične otopine natrijevog klorida ili u 500 ml 5%-tne otopine glukoze i primijeniti infuzijom u trajanju od 2 sata.
English: Tel: +385 1 30 111 28
Croatian: PROXIMUM d.o.o. Tel: +385 1 30 111 28
English: The deterioration in Quality of Life and WHO performance status was significantly less in Ibandronate treated patients compared with placebo.
Croatian: Pogoršanje kvalitete života i općeg stanja, prema WHO, bilo je znatno manje u bolesnika liječenih ibandronatom nego u bolesnika koji su primali placebo.
English: Children and adolescents Iasibon should not be used in children and adolescents below the age of 18 years.
Croatian: Djeca i adolescenti Iasibon se ne smije davati djeci i adolescentima mlađim od 18 godina.
English: • pelvic pain, discharge, itching or pain in the vagina
Croatian: • bolovi u zdjelici, vaginalni iscjedak, svrbež ili bol u rodnici
English: • The other ingredients are sodium chloride, glacial acetic acid, sodium acetate trihydrate and water for injections.
Croatian: • Drugi sastojci su natrijev klorid, ledena acetatna kiselina, natrijev acetat trihidrat i voda za injekcije.
English: The Star Medicines Importers Co. Ltd Τηλ: +357 25371056
Croatian: Ltd Τηλ: +357 25371056
English: Since Acetylsalicylic acid, Nonsteroidal Anti-Inflammatory medicinal products (NSAIDS) and bisphosphonates are associated with gastrointestinal irritation, caution should be taken during concomitant administration.
Croatian: Acetilsalicilatna kiselina i nesteroidni protuupalni lijekovi Budući da se acetilsalicilatna kiselina, nesteroidni protuupalni lijekovi i bisfosfonati povezuju s gastrointestinalnom iritacijom, potreban je oprez pri njihovoj istodobnoj primjeni.