FrancophonIA/ELRC3.0 huggingface dataset:
English: - Slow or difficult breathing (including when sleeping), Nose bleeds, hiccups.
Croatian: - Sporo ili otežano disanje (uključujući tijekom spavanja), krvarenje iz nosa, štucanje.
English: Risk from concomitant use of sedative medicines such as benzodiazepines or related medicinal products
Croatian: Rizik od istodobne primjene sedativnih lijekova kao što su benzodiazepini ili srodni lijekovi
English: Prior to the launch of Dzuveo in each Member State (MS), the Marketing Authorisation Holder (MAH) must agree about the content and format of the educational materials, including communication media, distribution modalities, and any other aspects of the programme, with the National Competent Authority (NCA).
Croatian: Prije puštanja u prodaju lijeka Dzuveo u svaku državu članicu, nositelj odobrenja za stavljanje lijeka u promet mora se o sadržaju i obliku obrazovnih materijala, uključujući sredstva komunikacije, načine distribucije i bilo kakve druge aspekte programa, dogovoriti s nacionalnim nadležnim tijelom.
English: Sufentanil should be used with caution in patients who may be particularly susceptible to the cerebral effects of CO2 retention, such as those with evidence of increased intracranial pressure or impaired consciousness.
Croatian: Sufentanil treba oprezno primjenjivati u bolesnika koji mogu biti posebno osjetljivi na cerebralne učinke zadržavanja CO2, poput onih s dokazanim povišenim intrakranijalnim tlakom ili poremećajem svijesti.
English: Caution should be exercised in patients on these concomitant medicinal products and they should be closely monitored.
Croatian: Potreban je oprez u bolesnika koji istodobno uzimaju te lijekove te ih je potrebno pomno pratiti.
English: Respiratory depression caused by sufentanil can be reversed by opioid antagonists.
Croatian: Respiratorna depresija uzrokovana sufentanilom može se suzbiti opioidnim antagonistima.
English: Patients were predominantly female (63%), mean age was 41 years (range 18-74 years), BMI 15.8 to 53.5 kg/m2, race was predominately White (69%) and Black or African American (21%).
Croatian: Bolesnici su bili pretežito žene (63 %), srednja vrijednost dobi bila je 41 godina (raspon od 18 do 74 godine), ITM od 15,8 do 53,5 kg/m2, rasa je bila pretežito bijela (69 %) i crna ili afroamerička (21 %).
English: Dzuveo affects your ability to drive or use machines as it may cause sleepiness, dizziness or visual disturbances.
Croatian: Dzuveo utječe na vašu sposobnost upravljanja vozilima ili strojevima jer može uzrokovati pospanost, omaglicu ili poremećaje vida.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON OF 5 OR 10 POUCHES
Croatian: PODATCI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKA KUTIJA S PET ILI DESET VREĆICA
English: Carcinogenicity Carcinogenicity studies have not been conducted with sufentanil.
Croatian: Karcinogenost Ispitivanja karcinogenosti nisu provedena sa sufentanilom.
English: The most serious side effects are severe breathing problems, like slow and shallow breathing, which may even lead to you stopping breathing.
Croatian: Najozbiljnije nuspojave su teški problemi s disanjem, kao što je sporo i plitko disanje, što može dovesti i do zaustavljanja disanja.
English: 3-4 Ballyboggan Industrial Estate Ballyboggan Road Finglas Dublin 11 Ireland
Croatian: 3-4 Ballyboggan Industrial Estate Ballyboggan Road Finglas Dublin 11 Irska
English: Very common ≥1/10 Common ≥1/100 to <1/10 Uncommon ≥1/1,000 to <1/100 Rare
Croatian: Manje često od ≥ 1/1000 do < 1/100 Rijetko od ≥ 1/10 000 do < 1/1000
English: In humans the potency is 7 to 10-fold higher than fentanyl and 500 to 1,000-fold higher than morphine (per oral).
Croatian: U ljudi je potentnost od sedam do deset puta veća od fentanila te od 500 do 1000 puta veća nego od morfina (primijenjenog peroralno).
English: Sufentanil may produce bradycardia.
Croatian: Sufentanil može izazvati bradikardiju.
English: Children and adolescents Dzuveo should not be used in children and adolescents below 18 years.
Croatian: Dzuveo se ne smije primjenjivati u djece i adolescenata mlađih od 18 godina.
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from sufentanil therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Croatian: Mora se donijeti odluka o prestanku dojenja ili trajnom/privremenom prekidu terapije sufentanilom, uzimajući u obzir korist dojenja za dijete i korist terapije za ženu.
English: With Dzuveo, first dose clearance in the typical patient of weight 78.5 kg and age 47 years is 84.2 L/hr.
Croatian: S lijekom Dzuveo, klirens prve doze u tipičnog bolesnika težine 78,5 kg i starosti 47 godina je 84,2 l/h.
English: See section 6.6 for instructions regarding handling of the Dzuveo sublingual tablet and applicator.
Croatian: Vidjeti dio 6.6. radi uputa o rukovanju Dzuveo sublingvalnom tabletom i aplikatorom.
English: - Problems coordinating muscle movements, muscle contractions, tremors or excessive shaking,
Croatian: - Problemi pri koordinaciji pokreta mišića, kontrakcije mišića, tremor ili pretjerana treskavica,
English: It measures 3 mm in diameter and is enclosed within a single-dose applicator (labelled [sublingual tablet]).
Croatian: Promjera je 3 mm i nalazi se unutar aplikatora za jednu dozu (s oznakom [sublingual tablet]).
English: Intracranial pressure
Croatian: Intrakranijalni tlak
English: Neoplasm benign, malignant and unspecified (including cysts and polyps)
Croatian: Dobroćudne, zloćudne i nespecificirane novotvorine (uključujući ciste i polipe)
English: Taking into account the PRAC Assessment Report on the PSUR(s) for sufentanil, the scientific conclusions of CHMP are as follows:
Croatian: Uzimajući u obzir PRAC-ovo izvješće o ocjeni periodičkog(ih) izvješća o neškodljivosti lijeka (PSUR) za sufentanil, znanstveni zaključci CHMP-a su sljedeći:
English: - Increased heart rate, high blood pressure, low blood pressure.
Croatian: - Povećana brzina otkucaja srca, visoki krvni tlak, niski krvni tlak.
English: This may range from hypoventilation to respiratory arrest.
Croatian: To može biti u rasponu od hipoventilacije do respiratornog zastoja.
English: This medicine must be given to you by a doctor or a nurse using the single-dose administration device.
Croatian: Ovaj lijek mora vam dati liječnik ili medicinska sestra pomoću uređaja za davanje jedne doze.
English: Interaction with calcium channel and/or beta blockers
Croatian: Interakcije s blokatorima kalcijevih kanala ili beta blokatorima
English: Contents of the pack and other information What Dzuveo contains - The active substance is sufentanil.
Croatian: Sadržaj pakiranja i druge informacije Što Dzuveo sadrži - Djelatna tvar je sufentanil.
English: The tablets dissolve under your tongue and should not be chewed, or swallowed because the tablet is not effective for pain relief unless it is allowed to dissolve under your tongue.
Croatian: Tablete se otapaju pod jezikom i ne smiju se žvakati niti progutati jer tableta nije učinkovita za smanjenje boli ako se ne omogući njezino otapanje pod jezikom.
English: Buccal administration showed an increased bioavailability of 78% when the tablets were placed in front of the front lower teeth.
Croatian: Bukalna primjena pokazala je povećanu bioraspoloživost od 78 % kada su tablete postavljene ispred prednjih donjih zuba.
English: - Regularly prescribed opioid medicine (e.g. morphine, codeine, fentanyl, hydromorphone, oxycodone).
Croatian: - Redovito propisivani opioidni lijek (npr. morfin, kodein, fentanil, hidromorfon, oksikodon).
English: If sufentanil is administered to the mother during this time, an antidote for the child should be readily available.
Croatian: Ako se tijekom tog razdoblja sufentanil daje majci, protulijek za dijete treba biti lako dostupan.
English: No special population studies were performed using Dzuveo in the elderly.
Croatian: Nisu provedena posebna ispitivanja populacije primjenom lijeka Dzuveo u starijih osoba.
English: 2D barcode carrying the unique identifier included.
Croatian: Sadrži 2D barkod s jedinstvenim identifikatorom
English: Sufentanil has major influence on the ability to drive and use machines.
Croatian: Sufentanil značajno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: • The key message to convey during patients counselling, about possible respiratory depression / overdose;
Croatian: • ključna poruka koju treba prenijeti tijekom savjetovanja bolesnika o mogućoj depresiji dišnog sustava/predoziranju;
English: Studies in animals have shown reproductive toxicity (see section 5.3).
Croatian: Ispitivanja provedena na životinjama utvrdila su reproduktivnu toksičnost (vidjeti dio 5.3.).
English: After multiple administrations, a longer mean terminal half-life of 15.7 hours (range 2.4 to 42.7 hours) was observed, owing to the higher plasma concentrations of sufentanil achieved after repeated dosing and due to the possibility to quantify these concentrations over a longer time period.
Croatian: Nakon višestrukih primjena, opažena je dulja srednja vrijednost terminalnog poluvijeka od 15,7 sati (raspon od 2,4 do 42,7 sati), zbog većih koncentracija sufentanila u plazmi postignutih nakon ponovljenog doziranja i zbog mogućnosti kvantificiranja tih koncentracija tijekom dužeg vremenskog perioda.
English: When Dzuveo is administered every hour, steady-state plasma concentrations are achieved by 7 doses.
Croatian: Kada se Dzuveo primjenjuje svakih sat vremena, koncentracije u plazmi u stanju dinamičke ravnoteže postižu se u sedam doza.
English: Similar effects with other potent CYP3A4 inhibitors (e. g. itraconazole, ritonavir) cannot be excluded.
Croatian: Ne mogu se isključiti slični učinci s drugim snažnim inhibitorima CYP3A4 (npr. itrakonazol, ritonavir).
English: Patient weight and age are key covariates on clearance.
Croatian: Težina i dob bolesnika ključne su kovarijate klirensa.
English: - Feeling agitated, lack of interest or emotion, lack of energy, disorientation, feeling elated,
Croatian: - Osjećaj uznemirenosti, nedostatak interesa ili emocija, nedostatak energije, dezorijentiranost,
English: After your treatment the medical staff will dispose of the applicator accordingly.
Croatian: Medicinsko osoblje će nakon liječenja zbrinuti aplikator na odgovarajući način.
English: Ketoconazole, a potent CYP3A4 inhibitor, can significantly increase the systemic exposure to sublingual sufentanil (maximal plasma levels (Cmax) increase of 19%, overall exposure to the active substance (AUC) increase of 77% and prolong the time to reach maximum concentration by 41%.
Croatian: Ketokonazol, snažan inhibitor CYP3A4, može znatno povećati sistemsku izloženost sublingvalnom sufentanilu (povećanje maksimalnih razina u plazmi (Cmax) od 19 %, povećanje ukupne izloženosti djelatnoj tvari (AUC) od 77 %) te produljiti vrijeme do postizanja maksimalne koncentracije za 41 %.
English: Cardiovascular stability is also the result of minimal effects on cardiac preload, cardiac flow rate and myocardial oxygen consumption.
Croatian: Kardiovaskularna stabilnost također je posljedica minimalnih učinaka na srčano predopterećenje, brzinu srčanog protoka i miokardijalnu potrošnju kisika.
English: - This medicine may also cause changes in levels of red blood cells, white blood cells, calcium,
Croatian: - Ovaj lijek može uzrokovati i promjene u razinama crvenih krvnih stanica, bijelih krvnih stanica,
English: Studies in rats have revealed reduced fertility and enhanced embryo mortality (see section 5.3).
Croatian: Istraživanja provedena na štakorima pokazala su smanjenu plodnost i povećanu smrtnost embrija (vidjeti dio 5.3.).
English: Local tolerance Two local tolerance studies were conducted in the hamster cheek pouch with the sufentanil sublingual tablets.
Croatian: Dva ispitivanja lokalne tolerancije provedena su u vrećici obraza hrčaka sa sublingvalnim tabletama sufentanila.
English: No specific dose adjustment is required in elderly patients.
Croatian: U starijih bolesnika nije potrebna nikakva posebna prilagodba doze.
English: By reporting side effects, you can help provide more information on the safety of this medicine.
Croatian: Prijavljivanjem nuspojava možete pridonijeti procjeni sigurnosti ovog lijeka.
English: - Pain in the back, chest or other body parts, pain in the extremities.
Croatian: - Bol u leđima, prsnom košu ili drugim dijelovima tijela, bol u udovima.
English: This medicine may also cause changes in levels of platelets (which help your blood to clot), magnesium, protein, sugar, fats, phosphates and plasma in your blood which can only be identified through a blood test.
Croatian: Ovaj lijek može uzrokovati i promjene u razinama trombocita (koji pomažu u zgrušavanju krvi), magnezija, bjelančevina, šećera, masti, fosfata i plazme u krvi, što se može utvrditi samo pomoću pretraga krvi.
English: Rest the SDA lightly on the patient's teeth or lips.
Croatian: Položite aplikator za jednu dozu lagano na zube ili usne bolesnika.
English: Sufentanil may cause hypotension, especially in hypovolemic patients.
Croatian: Sufentanil može prouzročiti hipotenziju, posebice u bolesnika s hipovolemijom.
English: Over 24 hours, the mean number of Dzuveo doses administered was 7.0 (210 micrograms/day).
Croatian: Tijekom 24 sata, srednja vrijednost broja primijenjenih doza lijeka Dzuveo bila je 7,0 (210 mikrograma dnevno).
English: Sufentanil should not be used in pregnancy, because it crosses the placenta and the foetal respiratory center is sensitive to opiates.
Croatian: Sufentanil se ne smije upotrebljavati u trudnoći jer prolazi kroz posteljicu, a respiratorno središte fetusa osjetljivo je na opijate.
English: Anaemia postoperative
Croatian: Postoperativna anemija
English: An opiate antagonist (e.g. naloxone) should be administered in the event of respiratory depression.
Croatian: Antagonist opijata (npr. nalokson) treba primijeniti u slučaju respiratorne depresije.
English: Frequency not known (frequency cannot be estimated from the available data): Severe allergic reactions (anaphylactic shock), convulsions (fits), coma, small pupil size, redness of the skin.
Croatian: Učestalost je nepoznata (ne može se procijeniti iz dostupnih podataka): - Teške alergijske reakcije (anafilaktički šok), konvulzije (napadaji), koma, mala veličina zjenica,
English: If swallowed, the oral bioavailability of Dzuveo is only 9% which would result in a subtherapeutic dose.
Croatian: Ako se proguta, oralna bioraspoloživost lijeka Dzuveo je samo 9 % što bi rezultiralo dozom koja je manja od terapijske doze.
English: Remove the white Lock from the green Pusher by squeezing the sides together and detaching from Pusher.
Croatian: Uklonite bijeli graničnik sa zelenog potisnika pritiskanjem strana prema unutra i skidanjem s potisnika.
English: Following long-term treatment sufentanil may cause withdrawl symptoms in the newborn.
Croatian: Nakon dugoročnog liječenja sufentanilom može doći do simptoma ustezanja (apstinencijske krize) u novorođenčeta.
English: The recommended dose is a maximum of one 30 microgram sublingual tablet per hour.
Croatian: Preporučena doza je maksimalno jedna sublingvalna tableta od 30 mikrograma na sat.
English: Appendix V
Croatian: u Dodatku V.
English: After single administration of Dzuveo, mean terminal phase half-live of 13.4 hours (range of 2.5 to 34.4 hours) was observed.
Croatian: Nakon jednokratne primjene lijeka Dzuveo zabilježena je srednja vrijednost poluvijeka terminalne faze od 13,4 sati (raspon od 2,5 do 34,4 sati).
English: You should only drive and use machines if sufficient time has elapsed after your last dose of Dzuveo.
Croatian: Smijete voziti i upravljati strojevima samo ako je proteklo dovoljno vremena nakon posljednje doze lijeka Dzuveo.
English: Sufentanil overdose is manifested by an exaggeration of its pharmacological effects.
Croatian: Predoziranje sufentanilom manifestira se pretjeranošću njegovih farmakoloških učinaka.
English: The applicator will help your healthcare provider place one tablet under your tongue.
Croatian: Aplikator će pomoći zdravstvenom radniku da vam postavi tabletu pod jezik.
English: The single-dose applicator (SDA) must be discarded in accordance to the institutional policies and local requirements.
Croatian: Aplikator za jednu dozu mora se zbrinuti u skladu s propisima institucije i nacionalnim propisima.
English: Sufentanil is used to treat sudden moderate-to-severe pain in adults in medically monitored settings such as a hospital.
Croatian: Sufentanil se primjenjuje za liječenje iznenadne umjerene do teške boli u odraslih u liječnički nadziranim okruženjima, kao što je bolnica.
English: Dzuveo is only used in a medically monitored setting, such as a hospital.
Croatian: Dzuveo se upotrebljava samo u liječnički nadziranom okruženju, kao što je bolnica.
English: The Ames test revealed no mutagenic activity of sufentanil.
Croatian: Amesov test nije pokazao mutageno djelovanje sufentanila.
English: For Dzuveo, population pharmacokinetic analysis showed an effect of age, with an 18% decrease in clearance in the elderly (above 65 years of age).
Croatian: Analiza populacijske farmakokinetike za lijek Dzuveo pokazala je učinak dobi uz smanjenje klirensa od 18 % u starijih osoba (starijih od 65 godina).
English: Patients should be advised not to drive or operate machinery if they experience somnolence, dizziness, or visual disturbance while taking or after the treatment with sufentanil.
Croatian: Bolesnike treba savjetovati da ne voze niti rade sa strojevima ako uoče somnolenciju, omaglicu ili poremećaj vida tijekom uzimanja sufentanila ili nakon liječenja sufentanilom.
English: Sufentanil may cause respiratory depression (see section 4.4) and also suppresses the cough reflex.
Croatian: Sufentanil može uzrokovati respiratornu depresiju (vidjeti dio 4.4.), a potiskuje i refleks kašlja.
English: Other medicines and Dzuveo Tell your doctor if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svojeg liječnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: There are no clinical data on the effects of sufentanil on fertility.
Croatian: Nema kliničkih podataka o učincima sufentanila na plodnost.
English: - Low levels of oxygen in your blood, feeling pain in the lower throat, slow shallow breathing.
Croatian: - Niska razina kisika u krvi, osjećaj bolova u donjem dijelu grla, sporo plitko disanje.
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom planu upravljanja rizikom (RMP), koji se nalazi u modulu 1.8.2. odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMPa.
English: The MAH shall ensure that in each MS where Dzuveo is marketed, all HCPs (i.e. physicians, hospital pharmacists, and nurses) who are expected to prescribe / administer the product are provided with a Healthcare Professional Guide, outlining critical information for the safe and effective use of Dzuveo, including:
Croatian: Nositelj odobrenja će osigurati da u svakoj državi članici u kojoj je Dzuveo na tržištu svi zdravstveni radnici (liječnici, bolnički ljekarnici i medicinske sestre) za koje se očekuje da će propisivati/primjenjivati lijek dobiju vodič za zdravstvene radnike, u kojem se navode ključne informacije za sigurnu i učinkovitu primjenu lijeka Dzuveo, uključujući:
English: Effect of BMI on dosing
Croatian: Učinak ITM-a na doziranje
English: MARKETING AUTHORISATION NUMBER(S) EU/1/18/1284/001 EU/1/18/1284/002
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/18/1284/001 EU/1/18/1284/002
English: albumin, potassium and sodium in your blood which can only be identified through a blood test.
Croatian: kalcija, albumina, kalija i natrija u krvi, što se može utvrditi samo pomoću pretraga krvi.
English: Pharmacokinetic/Pharmacodynamic Relationship
Croatian: Farmakokinetički/farmakodinamički odnos
English: Urinary retention Urinary hesitation Oliguria
Croatian: Urinarna retencija Odgađanje uriniranja Oligurija
English: In the two placebo-controlled clinical trials, the mean number of doses used in the first 6 hours of dosing was 2.8 tablets, with less frequent dosing in the following 6 hours (mean of 1.7 tablets).
Croatian: U dva placebom kontrolirana klinička ispitivanja, srednja vrijednost broja doza korištenih u prvih 6 sati doziranja iznosila je 2,8 tableta, uz manje često doziranje u sljedećih 6 sati (srednja vrijednost od 1,7 tableta).
English: How to use Dzuveo
Croatian: Kako uzimati Dzuveo
English: The dispensed sublingual tablet should dissolve under the tongue and should not be chewed or swallowed.
Croatian: Sublingvalna tableta koja je stavljena pod jezik treba se otopiti pod jezikom te se ne smije žvakati ili progutati.
English: Other symptoms that may occur are loss of consciousness, coma, cardiovascular shock and muscle rigidity.
Croatian: Drugi simptomi koji mogu nastati su gubitak svijesti, koma, kardiovaskularni šok i krutost mišića.
English: Dzuveo is indicated for the management of acute moderate to severe pain in adult patients.
Croatian: Dzuveo je indiciran za liječenje akutne umjerene do teške boli u odraslih bolesnika.
English: Depress the green Pusher to deliver the tablet to the patient's sublingual space and confirm tablet placement.
Croatian: Pritisnite zeleni potisnik da biste stavili tabletu u bolesnikov sublingvalni prostor i provjerite je li tableta na mjestu.
English: You should not drive or operate machinery if you experience any of these symptoms whilst or after being treated with sufentanil.
Croatian: Nemojte voziti niti upravljati strojevima ako primijetite bilo koji od ovih simptoma tijekom ili nakon liječenja sufentanilom.
English: A medically monitored setting must have equipment and personnel trained to detect and manage hypoventilation, and availability of supplemental oxygen and opioid antagonists, such as naloxone.
Croatian: Okruženje pod liječničkim nadzorom mora imati opremu i osoblje osposobljeno za otkrivanje i liječenje hipoventilacije te dostupnost dopunskog kisika i opioidnih antagonista, kao što je nalokson.
English: - Medicines used to treat high blood pressure or angina (chest pain) known as calcium channel or beta blockers e.g. diltiazem and nifedipine.
Croatian: - Lijekovi koji se primjenjuju za liječenje visokog krvnog tlaka ili angine (bol u prsima) poznati kao blokatori kalcijevih kanala ili beta blokatori, npr. diltiazem i nifedipin.
English: Sufentanil may increase plasma serotonin level and its concomitant use with other serotoninergic agents may increase the risk of serotonin syndrome.
Croatian: Sufentanil može povisiti razine serotonina u plazmi te njegova istodobna primjena s drugim serotoninergičkim lijekovima može povećati rizik od serotoninskog sindroma.
English: Mean absolute bioavailability after a single sublingual administration of the sufentanil tablet relative to a one-minute intravenous sufentanil infusion of the same dose was 53%.
Croatian: Srednja vrijednost apsolutne bioraspoloživosti nakon jedne sublingvalne primjene tablete sufentanila u odnosu na jednominutnu intravenoznu infuziju iste doze sufentanila bila je 53 %.
English: The high lipophilicity of sufentanil allows it to be administered sublingually and achieve a rapid onset of analgesic effect.
Croatian: Visoka lipofilnost sufentanila omogućuje da se primjeni sublingvalno i postigne brz nastup analgetskog učinka.
English: Interaction with other sublingually administered products or products intended to dilute/establish an effect in the oral cavity were not evaluated and simultaneous administration should be avoided.
Croatian: Interakcije s drugim proizvodima koji se primjenjuju sublingvalno ili proizvodima koji su namijenjeni za razrjeđivanje / uspostavljanje učinka u usnoj šupljini nisu procijenjene te je potrebno izbjegavati istodobnu primjenu.
English: - High blood pressure or low blood pressure when standing up, skin flushing.
Croatian: - Visoki krvni tlak ili niski krvni tlak pri ustajanju, navala crvenila kože.