FrancophonIA/ELRC3.0 huggingface dataset:
English: Cases of severe skin reactions have been reported postmarketing (including Stevens-Johnson syndrome and toxic epidermal necrolysis).
Maltese: Ġew irrapportati każijiet ta' reazzjonijiet severi tal-ġilda wara li l-prodott tqiegħed fis-suq (li jinkludu ssindromu ta' Stevens-Johnson u n-nekrolisi epidermali tossika).
English: Neutropeniab, Anaemia
Maltese: Newtropenijab Anemija,
English: Adverse reactions reported with AUBAGIO in placebo-controlled studies, reported for teriflunomide 7 mg or 14 mg at ≥ 1% higher rate than for placebo, are shown below.
Maltese: Reazzjonijiet avversi rrappurtati b'AUBAGIO fi studji kkontrollati bi plaċebo, irrappurtati għal teriflunomide 7 mg jew 14 mg b'rata ogħla ta' ≥ 1% minn plaċebo, qed jintwerew hawn taħt.
English: Pharmacokinetic interactions of teriflunomide on other substances
Maltese: Interazzjonijiet farmakokinetiċi ta' teriflunomide fuq sustanzi oħra
English: Repeated doses of teriflunomide decreased mean Cmax and AUC of caffeine (CYP1A2 substrate) by 18% and 55%, respectively, suggesting that teriflunomide may be a weak inducer of CYP1A2 in vivo.
Maltese: L-effett ta' teriflunomide fuq substrat ta' CYP1A2: kaffeina Dożi ripetuti ta' teriflunomide naqqsu l-medja tas-Cmax u l-AUC ta' kaffeina (substrat ta' CYP1A2) bi 18% u
English: Therefore, when teriflunomide is coadministered with substrates of OAT3, such as cefaclor, benzylpenicillin, ciprofloxacin, indometacin, ketoprofen, furosemide, cimetidine, methotrexate, zidovudine, caution is recommended.
Maltese: Għalhekk, meta teriflunomide jingħata flimkien ma' substrati ta' OAT3, bħal cefaclor, benzylpenicillin, ciprofloxacin,
English: Teriflunomide is contraindicated in pregnancy (see section 4.3).
Maltese: Teriflunomide huwa kontraindikat waqt it-treddigħ (ara sezzjoni 4.3).
English: Use of alternative contraceptive methods is recommended.
Maltese: kontraċezzjoni alternattivi hu rakkomandat.
English: Studies in animals have shown reproductive toxicity (see section 5.3).
Maltese: Studji f'annimali urew effett tossiku fuq is sistema riproduttiva (ara sezzjoni 5.3).
English: A reminder for both patients and all HCPs involved in their treatment that the patient is being treated with teriflunomide, a medicine which:
Maltese: Nota kemm għall-pazjenti kif ukoll għall-HCPs involuti fil-kura tagħhom biex ma jinsewx li l-pazjent qed jiġi kkurat b'teriflunomide, mediċina li:
English: In placebo-controlled studies, peripheral neuropathy, including both polyneuropathy and mononeuropathy (e.g., carpal tunnel syndrome), was reported more frequently in patients taking teriflunomide than in patients taking placebo.
Maltese: Fi studji kkontrollati bi plaċebo, newropatija periferali, li tinkludi kemm polinewropatija kif ukoll mononewropatija (eż., sindrome tal-carpal tunnel), ġiet irrappurtata b'mod iktar frekwenti f'pazjenti li kienu qed jieħdu teriflunomide milli f'pazjenti li kienu qed jieħdu plaċebo.
English: Women of childbearing potential have to use effective contraception during treatment and after treatment as long as teriflunomide plasma concentration is above 0.02 mg/l.
Maltese: Nisa li jistgħu joħorġu tqal għandhom jużaw kontraċettiv effettiv waqt u wara t-trattament sakemm ilkonċentrazzjoni ta' teriflunomide fil-plażma tibqa' ogħla minn 0.02 mg/l.
English: Teriflunomide was embryotoxic and teratogenic in rats and rabbits at doses in the human therapeutic range.
Maltese: Teriflunomide kien embrijotossiku u teratoġeniku fil-firien u fil-fniek f'dożi fil-medda terapewtika umana.
English: Calendar days Mon
Maltese: Pressjoni tad-demm
English: • Risk of infections/serious infections o To discuss the need to contact the doctor in the event of signs/symptoms of infection, or if the patient takes other medicines that affect the immune system 2.
Maltese: • Riskju ta'infezzjonijiet/infezzjonijiet serji o Li jiġi diskuss il-bżonn li wieħed jikkuntattja lit-tabib f'każ ta'sinjali/sintomi ta' infezzjoni,
English: • Potential risk of teratogenicity o To check pregnancy status before starting treatment o To educate female patients of child-bearing potential on the need for effective contraception before starting, and during treatment with teriflunomide o To inform their doctor immediately if they stop contraception, or prior to changing contraceptive measures o If female patients become pregnant despite using contraceptive measures, they should stop teriflunomide and contact their doctor immediately who should: Consider and discuss with the patient the accelerated elimination procedure encourage them to enrol in a pregnancy registry (in countries where a pregnancy registry is on-going),
Maltese: • Riskju ta' pressjoni għolja o Biex jiġi ċċekkjat jekk kienx hemm storja ta' pressjoni għolja u li l-pressjoni għanda tiġi mmaniġġjata b'mod xieraq waqt il-kura o il-bżonn ta' iċċekkjar tal-pressjoni qabel il-kura u perjodikament waqt il-kura,
English: AUBAGIO helps to protect against attacks on the central nervous system by the immune system by limiting the increase of some white blood cells (lymphocytes).
Maltese: AUBAGIO jgħin biex jipproteġi kontra attakki fuq is-sistema nervuża ċentrali mis-sistema immuni billi jillimita ż-żieda ta' xi ċelluli bojod tad-demm (limfoċiti).
English: Pregnant women, or women of childbearing potential who are not using reliable contraception during treatment with teriflunomide and thereafter as long as its plasma levels are above 0.02 mg/l (see section 4.6).
Maltese: Nisa tqal, jew nisa li jistgħu joħorġu tqal li ma jkunux qed jużaw kontraċezzjoni affidabbli matul il-kura b'teriflunomide u wara sakemm il-livelli tiegħu fil-plażma jkunu ogħla minn 0.02 mg/l (ara sezzjoni 4.6).
English: Very common
Maltese: Total ta'
English: A consistent treatment effect on relapses and time to 3-month sustained disability progression in a subgroup of patients in TEMSO (n 127) with high disease activity was observed.
Maltese: Kien osservat effett konsistenti tal-kura fuq ir-rikaduti u ż-żmien għal progressjoni għal diżabilità sostnuta ta' 3 xhur f'sottogrupp ta' pazjenti f'TEMSO (n= 127) b'attivita qawwija tal-marda.
English: PC: SN: NN:
Maltese: Informazzjoni li teduka lill-pazjent:
English: Mild thrombocytopen ia (platelets <100G/l)
Maltese: Żieda fil-livell ta' gammaglutamyltransferase (GGT)b
English: Menorrhagia
Maltese: - Porjasi
English: The efficacy of AUBAGIO was demonstrated in two placebo controlled studies, the TEMSO and the TOWER study, that evaluated once daily doses of teriflunomide 7 mg and 14 mg in patients with RMS.
Maltese: TOWER, li evalwaw dożi darba kuljum ta' teriflunomide 7 mg u 14-il mg f'pazjenti b'RMS.
English: Change in BOD week 108(1)
Maltese: Bidla fil-BOD week 108 Bidla meta mqabbla ma'
English: Use in males
Maltese: TA' EĊĊIPJENTI
English: In patients treated with leflunomide, the parent compound, very rare cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) have also been reported.
Maltese: F'pazjenti kkurati b'leflunomide, il-kompost oriġinali, ġew irrappurtati wkoll każijiet rari ħafna ta'rReazzjoni għall-Mediċina b'Eosinophilia u Sintomi Sistemiċi (DRESS).
English: - Keep this leaflet.
Maltese: - tkun se tingħata tilqima.
English: The mean age of the study population was 37.9 years.
Maltese: L-età medja tal-popolazzjoni tal-istudju kienet ta' 37.9 snin.
English: Clinical Outcomes
Maltese: Riżultati kliniċi
English: A total of 1169 patients with RMS were randomised in TOWER to receive 7 mg (n=408) or 14 mg (n=372) of teriflunomide or placebo (n= 389) for a variable treatment duration ending at 48 weeks after last patient randomised.
Maltese: Total ta' 1169 pazjent b'RMS intgħażlu b'mod każwali fl-istudju TOWER biex jirċievu 7 mg (n=408) jew 14
English: Contents of the pack and other information What AUBAGIO contains
Maltese: INFORMAZZJONI BIL-BRAILLE AUBAGIO
English: However, teriflunomide is contraindicated in patients with severe hepatic impairment (see sections 4.2 and 4.3).
Maltese: Madankollu, teriflunomide hu kontraindikat f'pazjenti b'indeboliment sever tal-fwied (ara sezzjonijiet 4.2 u 4.3).
English: Influenza, Upper respiratory tract infection, Urinary tract infection, Bronchitis, Sinusitis, Pharyngitis, Cystitis, Gastroenteritis viral,
Maltese: - Influwenza, infezzjoni fin-naħa ta' fuq tal-apparat respiratorju, infezzjoni fl-apparat tal-awrina bronkite, sinożite, uġigħ fil-griżmejn u skonfort meta tibla', ċistite, gastroenterite virali, erpete orali, infezzjoni fis-snien, larinġite, infezzjoni fungali tas-sieq
English: Hepatic effects During placebo-controlled studies the following was detected:
Maltese: Matul l-istudji kkontrollati bi plaċebo, ġie osservat dan li ġej:
English: Effect on renal tubular functions
Maltese: Effetti sekondarji serji
English: In case of ulcerative stomatitis, teriflunomide administration should be discontinued.
Maltese: F'każ ta' stomatite ulċerattiva, l-għoti ta' teriflunomide għandu jitwaqqaf.
English: Based on individual prediction of pharmacokinetic parameters using the PopPK model of teriflunomide in healthy volunteers and MS patients, median t1/2z was approximately 19 days after repeated doses of 14 mg. After a single intravenous administration, the total body clearance of teriflunomide is 30.5 ml/h.
Maltese: Ibbażat fuq tbassir individwali ta' parametri farmakokinetiċi bl-użu tal-mudell PopPK ta' teriflunomide f'voluntiera f'saħħithom u pazjenti b'MS, il medjan ta' t1/2z kien madwar 19-il jum wara dożi ripetuti ta' 14-il mg.
English: The risk of failure (confirmed relapse or permanent treatment discontinuation whichever came first) was the primary endpoint.
Maltese: Ir-riskju ta' falliment (rikaduta kkonfermata jew twaqqif permanenti tal-kura, liema minnhom seħħ l-ewwel) kien il-punt aħħari primarju.
English: AUBAGIO is for oral use.
Maltese: AUBAGIO hu gћall-użu orali.
English: Teriflunomide is contraindicated in patients with severe hepatic impairment (see section 4.3).
Maltese: Teriflunomide hu kontraindikat f'pazjenti b'indeboliment sever tal-fwied (ara sezzjoni 4.3).
English: • cholestyramine 8 g is administered 3 times daily for a period of 11 days, or cholestyramine 4 g three times a day can be used, if cholestyramine 8 g three times a day is not well tolerated,
Maltese: • cholestyramine 8 g jingħata 3 darbiet kuljum għal perjodu ta' 11-il jum, jew cholestyramine 4 g tliet darbiet kuljum jista' jintuża, jekk cholestyramine 8 g tliet darbiet kuljum ma jkunux ittollerat tajjeb, • alternattivament, 50 g ta' trab ta' faħam attivat għall-ħalq jingħata kull 12-il siegħa għal 11-il jum.
English: Systemic exposure increases in a dose proportional manner after oral administration teriflunomide from 7 to 14 mg.
Maltese: Esponiment sistemiku jiżdied b'mod proporzjonali mad-doża wara l-għoti mill-ħalq ta' teriflunomide minn 7 sa 14-il mg.
English: At entry, patients had an Expanded Disability Status Scale (EDSS) score ≤5.5.
Maltese: ≤5.5 fuq l-Iskala tal-Istat ta' Diżabilità Mkabbra (EDSS).
English: Hypoproteinaemia
Maltese: Ipoproteinimja
English: Repeated doses of teriflunomide had no effect on the pharmacokinetics of S-warfarin, indicating that teriflunomide is not an inhibitor or an inducer of CYP2C9.
Maltese: L-effett ta' teriflunomide fuq warfarin Dożi ripetuti ta' teriflunomide ma kellhom l-ebda effett fuq il-farmakokinetika ta' warfarin S, u dan jindika li teriflunomide mhuwiex inibitur jew induttur ta' CYP2C9.
English: Teriflunomide is contraindicated during breast-feeding (see section 4.3).
Maltese: Teriflunomide huwa kontraindikat f'din il-popolazzjoni (ara sezzjoni 4.3).
English: Change relative to placebo (CI95%) Number of unique active lesions /scan Change relative to placebo (CI95%)  p<0.0001  p<0.001  p<0.01  p<0.05 compared to placebo (1) BOD: burden of disease: total lesion volume (T2 and T1 hypointense) in ml
Maltese: Sensittività eċċessiva għas-sustanza attiva jew għal kwalunkwe wieћed mill-eċċipjenti elenkati fis sezzjoni 6.1. Pazjenti b'indeboliment sever tal-fwied (Child-Pugh klassi Ċ).
English: For rosuvastatin, a dose reduction by 50% is recommended for coadministration with teriflunomide.
Maltese: Għal rosuvastatin, tnaqqis ta' 50% fid-doża hu rakkomandat għall-għoti flimkien ma' teriflunomide.
English: 14 film-coated tablets 28 film-coated tablets
Maltese: 14-il pillola miksija b'rita 28 pillola miksija b'rita
English: For patients testing positive in tuberculosis screening, treat by standard medical practice prior to therapy with AUBAGIO.
Maltese: Għal pazjenti li jkollhom riżultat pożittiv fl-eżami għat-tuberkulosi, ikkura skont il-prattika medika standard qabel it-terapija b'AUBAGIO.
English: The volume of distribution is 11 l after a single intravenous (IV) administration.
Maltese: Il-volum tad-distribuzzjoni hu ta' 11 l wara għoti ta' darba ġol-vini (IV).
English: • Blood pressure o Check periodically
Maltese: • Pressjoni tad-demm o Iċċekkjata perjodikament
English: The mean number of relapses within the year before study inclusion was 1.4 with 36.2% of patients having gadolinium-enhancing lesions at baseline.
Maltese: In-numru medju ta' rikaduti fis-sena ta' qabel id-dħul fl-istudju kien ta' 1.4 b'36.2% tal-pazjenti jkollhom leżjonijiet li jidhru aktar b'gadolinium fil-linja bażi.
English: The placebo-controlled pooled analysis was based on 2047 patients with Relapsing Multiple Sclerosis treated with teriflunomide once daily.
Maltese: L-analiżi miġbura kkontrollata bi plaċebo ġiet ibbażata fuq 2047 pazjent bi Sklerożi Multipla li Tirkadi,
English: Hepatobiliary disorders
Maltese: Mijalġja Artralġja
English: In particular, tell your doctor or pharmacist if you are taking any of the following: - leflunomide, methotrexate and other medicines that affect the immune system (often called immunosuppressants or immunomodulators) - rifampicin (a medicine used to treat tuberculosis and other infections) - carbamazepine, phenobarbital, phenytoin for epilepsy - St John's wort (a herbal medicine for depression) - repaglinide, pioglitazone, nateglinide, or rosiglitazone for diabetes - daunorubicin, doxorubicin, paclitaxel, or topotecan for cancer - duloxetine for depression, urinary incontinenece or in kidney disease in diabetics - alosetron for the management of severe diarrhea - theophylline for asthma - tizanidine, a muscle relaxant - warfarin, an anticoagulant used to make the blood thinner (i.e. more fluid) in order to avoid blood clots - oral contraceptives (containing ethinylestradiol and levonorgestrel)
Maltese: Għid lit-tabib tiegħek immedjatament, jekk tinnota kwalunkwe wieħed mill-effetti sekondarji serji li ġejjin: - reazzjonijiet allerġiċi li jistgħu jinkludu sintomi ta' raxx, urtikarja,nefħa tax-xufftejn, ilsien jew wiċċ jew diffikultà f'daqqa biex tieħu n-nifs - reazzjonijiet severi fil-ġilda li jistgħu jinkludu sintomi bħal raxx fil-ġilda, infafet jew ulċeri fil-ħalq
English: ILD may occur acutely at any time during therapy with a variable clinical presentation.
Maltese: ILD jista' jseħħ b'mod akut f'kwalunkwe żmien waqt it-terapija bi preżentazzjoni klinika li tvarja.
English: Hazard ratio (CI95%) 3-month Sustained Disability Progression week
Maltese: Proporzjon ta' periklu (CI95%) Skopijiet finali tal-MRI
English: - severe skin reactions which might include symptoms of skin rash, blistering, or ulcers in your mouth - severe infections or sepsis (a potentially life-threatening type of infection) which might include symptoms of high fever, shaking, chills, reduced urine flow, or confusion - serious liver disease which might include symptoms of yellowing of your skin or the whites of your eyes, darker urine than normal, unexplained nausea and vomiting, or abdominal pain - inflammation of the lungs which might include symptoms of shortness of breath or persistent cough - inflammation of the pancreas which might include symptoms of severe pain in the upper abdominal area that may also be felt in your back, nausea, or vomiting
Maltese: Sintomi pulmonari li jkunu ġodda jew li jmorru għall-agħar, bħal sogħla persistenti u qtugħ ta' nifs, jistgħu jkunu raġuni għat-twaqqif tat-terapija u għal investigazzjoni addizzjonali, skont il-ħtieġa.
English: Repeated oral administration of teriflunomide to mice, rats and dogs for up to 3, 6, and 12 months, respectively, revealed that the major targets of toxicity were the bone marrow, lymphoid organs, oral cavity/ gastro intestinal tract, reproductive organs, and pancreas.
Maltese: żvela li l-miri ewlenin tat-tossiċità kienu l-mudullun, l-organi limfojdi, il-kavità orali/ il-passaġġ gastrointestinali, l-organi riproduttivi, u l-frixa.
English: In general, headache, diarrhoea, nausea and alopecia, were mild to moderate, transient and infrequently led to treatment discontinuation.
Maltese: B'mod ġenerali, l-uġigħ ta' ras, id-dijarea, id-dardir u l-alopeċja, kienu minn ħfief sa moderati, temporanji u wasslu b'mod mhux frekwenti għat-twaqqif tal-kura.
English: A mean decrease affecting white blood cell (WBC) count (<15% from baseline levels, mainly neutrophil and lymphocytes decrease) was observed in placebo-controlled trials with AUBAGIO, although a greater decrease was observed in some patients.
Maltese: Tnaqqis medju li jaffettwa l-għadd ta' ċelluli tad-demm bojod (WBC) (<15% mil-livelli fil-linja bażi, il-biċċa l-kbira tnaqqis fin-newtrofili u limfoċiti) ġie osservat fi provi kkontrollati bi plaċebo b'AUBAGIO, għalkemm tnaqqis ikbar ġie osservat f'xi pazjenti.
English: Based on the clinical data related to concomitant administration of teriflunomide with interferon beta or with glatiramer acetate, no waiting period is required when initiating teriflunomide after interferon beta or glatiramer acetate or when starting interferon beta or glatiramer acetate, after teriflunomide.
Maltese: Żewġ studji kliniċi wrew li t-tilqim kontra neoantiġeni (l-ewwel tilqima) jew kontra antiġeni li diġà huma preżenti (espożizzjoni mill-ġdid) u li huma inattivati kienu sikuri u effettivi waqt il-kura b'AUBAGIO.
English: What you need to know before you take AUBAGIO 3.
Maltese: X'għandek tkun taf qabel ma tieħu AUBAGIO 3.
English: Severe renal impairment had no impact on the pharmacokinetic of teriflunomide.
Maltese: Indeboliment tal-kliewi Indeboliment sever tal-kliewi ma kellu l-ebda impatt fuq il-farmakokinetika ta' teriflunomide.
English: Therefore, medicinal products metabolised by CYP2C8, such as repaglinide, paclitaxel, pioglitazone or rosiglitazone, should be used with caution during treatment with teriflunomide.
Maltese: Għalhekk, prodotti mediċinali li jiġu metabolizzati minn CYP2C8, bħal repaglinide, paclitaxel, pioglitazone jew rosiglitazone, għandhom jintużaw b'kawtela matul il-kura b'teriflunomide.
English: However, also following either of the accelerated elimination procedures, verification by 2 separate tests at an interval of at least 14 days and a waiting period of one-and-a-half months between the first occurrence of a plasma concentration below 0.02 mg/l and fertilisation is required.
Maltese: Madankollu, anki wara kwalunkwe waħda mill-proċeduri ta' eliminazzjoni aċċellerata, hemm bżonn li ssir verifika permezz ta' 2 testijiet separati b'intervall ta' mill-inqas 14-il jum u perjodu ta' stennija ta' xahar u nofs bejn l-ewwel okkorrenza ta' konċentrazzjoni fil-plażma ta' inqas minn 0.02 mg/l u l-fertilizzazzjoni.
English: Pharmacokinetic interactions of other substances on teriflunomide
Maltese: Interazzjoni ma' prodotti mediċinali oħra u forom oħra ta' interazzjoni Interazzjonijiet farmakokinetiċi ta' sustanzi oħra fuq teriflunomide
English: As a consequence teriflunomide reduces the proliferation of dividing cells that need de novo synthesis of pyrimidine to expand.
Maltese: Konsegwenza ta' dan, teriflunomide jnaqqas il-proliferazzjoni ta' ċelluli li qed jiddividu li għandhom bżonn is-sintesi de novo ta' pyrimidine biex jespandu.
English: Each film-coated tablet contains 14 mg of teriflunomide.
Maltese: Id-doża rakkomandata ta' teriflunomide hija ta' 14-il mg darba kuljum.
English: - you take leflunomide with AUBAGIO.
Maltese: Meta taqleb minn jew għal AUBAGIO
English: The long term safety of these combinations in the treatment of multiple sclerosis has not been established.
Maltese: Is-sigurtà fit-tul ta' dawn il kombinazzjonijiet fil-kura ta' sklerożi multipla ma ġietx stabbilita.
English: Post-traumatic pain a: please refer to the detailed description section b: see section 4.4
Maltese: Uġigħ wara xi trawma a: jekk jogħġbok irreferi għas-sezzjoni ta' deskrizzjoni dettaljata b. ara sezzjoni 4.4
English: AUBAGIO contains the active substance teriflunomide which is an immunomodulatory agent and adjusts the immune system to limit its attack on the nervous system.
Maltese: X'inhu AUBAGIO AUBAGIO fih is-sustanza attiva teriflunomide li hija sustanza immunomodulatorja u taġġusta s-sistema immuni sabiex trażżan l-attakki tagħha fuq is-sistema nervuża.
English: The measurement of ionised calcium levels might show falsely decreased values under treatment with leflunomide and/or teriflunomide (the active metabolite of leflunomide) depending on the type of ionised calcium analyser used (e.g. blood gas analyser).
Maltese: Tfixkil fil-kalkolu tal-livelli tal-kalċju jonizzat Skont it-tip ta' analizzatur tal-kalċju jonizzat li jintuża (e.ż. analizzatur tal-gass fid-demm), l-evalwazzjoni tal-livelli tal-klaċju jonizzat tista' turi valuri mnaqqsa falzi waqt il-kura b'leflunomide u/jew teriflunomide
English: As leflunomide is the parent compound of teriflunomide, co-administration of teriflunomide with leflunomide is not recommended.
Maltese: Billi leflunomide hu l-kompost oriġinali ta' teriflunomide, l-għoti ta' teriflunomide flimkien ma' leflunomide mhuwiex rakkomandat.
English: If this is not well tolerated, cholestyramine 4 g three times a day for 11 days can be used.
Maltese: Jekk ma jkunx ittollerat tajjeb, cholestyramine 4 g tliet darbiet kuljum għal 11-il jum jista' jintuża.
English: The estimated female plasma exposure via the semen of a treated patient is expected to be 100 times lower than the plasma exposure after 14 mg of oral teriflunomide.
Maltese: L-istima talesponiment fil-plażma tal-mara permezz tal-isperma ta' pazjent ikkurat hi mistennija li tkun 100 darba iktar baxxa mill-esponiment fil-plażma wara doża orali ta' 14 mg ta' teriflunomide.
English: People with relapsing form of multiple sclerosis will have repeated attacks (relapses) of physical symptoms caused by their nerves not working properly.
Maltese: Nies b'forma ta' sklerożi multipla li tirkadi se jkollhom attakki ripetuti (rikaduti) ta' sintomi fiżiċi kkawżati min-nervaturi tagħhom li ma jkunux qed jaħdmu kif suppost.
English: The mean duration of disease, since first symptoms, was 8.7 years.
Maltese: It-tul ta' żmien medju tal-marda, mill-ewwel sintomi, kien ta' 8.7 snin.
English: Jana Husa 1a
Maltese: Husa 1a
English: HU - Hungary sanofi-aventis zrt.
Maltese: HU - L-Ungerija sanofi-aventis zrt.
English: A-2102 Bisamberg
Maltese: A-2102 Bisamberg Austria
English: Av. Tomás Ribeiro, 43 - Bloco 1, 4º BEdifício Neopark
Maltese: Tomás Ribeiro, 43 - Bloco 1, 4º BEdifício Neopark
English: 2114 Aglantzia
Maltese: 2114 Aglantzia Lefkosia
English: Edifício Atlas II, Av. José Gomes Ferreira, N.º 11 - 3º, Sala 31
Maltese: José Gomes Ferreira, N.º 11 - 3º, Sala 31
English: BG - Bulgaria Chaikapharma - Highquality medicines AD, 1 G.M.Dimitrov Blvd
Maltese: BG - Il-Bulgarija Chaikapharma - Highquality medicines AD, 1 G.M.Dimitrov Blvd
English: Edifício D. Amélia, Piso 1, Ala B 2770-229 Paço de Arcos Portugal
Maltese: Amélia, Piso 1, Ala B 2770-229 Paço de Arcos Portugal
English: Rua Engenheiro Ferreira Dias, 728, 3º Piso Sul 4149-014 Porto Portugal
Maltese: Rua Engenheiro Ferreira Dias, 728, 3º Piso Sul 4149-014
English: 25125 Brescia Italy
Maltese: 25125 Brescia
English: BG - Bulgaria Inbiotech Ltd 5A Triaditza str.
Maltese: BG - Il-Bulgarija Inbiotech Ltd 5A Triaditza str.
English: SK - Slovakia Zentiva k.s., Evropská 846/176a, 160 00, Praha
Maltese: SK - Is-Slovakkja Zentiva k.s., Evropská 846/176a, 160 00, Praha
English: RO - Romania S.C. FARMEX COMPANY SRL Str.Drumul Potcoavei nr. 30, Pipera Voluntari, Jud.
Maltese: FARMEX COMPANY SRL Str.Drumul Potcoavei nr. 30, Pipera Voluntari, Jud.
English: BG - Bulgaria CSC Pharmaceuticals Ltd-Bulgaria EOOD, 10 Assen Jordanov str.,
Maltese: BG - Il-Bulgarija CSC Pharmaceuticals Ltd-Bulgaria EOOD, 10 Assen Jordanov str.,