FrancophonIA/ELRC3.0 huggingface dataset:
English: It's important not to stop taking Stribild without talking to your doctor: see section 3, Do not stop taking Stribild.
Slovenian: Pomembno je, da zdravila Stribild ne prenehate jemati, ne da bi se pogovorili z zdravnikom: glejte poglavje 3, Ne prenehajte jemati zdravila Stribild.
English: • contraceptive pill, used to prevent pregnancy
Slovenian: • kontracepcijske tablete, ki se uporabljajo za preprečevanje nosečnosti
English:  Tell your doctor if you are taking these or any other medicines.
Slovenian:  Povejte zdravniku, če jemljete ta ali katera koli druga zdravila.
English: • One tablet each day by mouth, with food.
Slovenian: • ena tableta se zaužije vsak dan s hrano.
English: DOAC = direct oral anticoagulant
Slovenian: DOAC = neposredni peroralni antikoagulant
English: When treating HIV infection, it is not always possible to tell whether some of the unwanted effects are caused by Stribild or by other medicines that you are taking at the same time, or by the HIV disease itself.
Slovenian: Pri zdravljenju okužbe z virusom HIV ni vedno mogoče povedati, ali nekatere od naštetih neželenih učinkov povzroča zdravilo Stribild ali druga zdravila, ki jih jemljete sočasno, ali sama bolezen HIV.
English: Once you start taking Stribild, look out for:
Slovenian: Ko začnete jemati zdravilo Stribild, bodite pozorni na:
English: If this is unavoidable, your doctor will monitor your kidney function more frequently.
Slovenian: Če je to neizogibno, bo zdravnik bolj pogosto nadzoroval funkcijo vaših ledvic.
English: For both studies at 48 weeks, the virologic response rate was evaluated in both treatment arms.
Slovenian: Za obe študiji so v 48. tednu stopnjo virološkega odziva ocenili v obeh skupinah zdravljenja.
English: Decreases in BMD of hip were significantly greater in this group until 96 weeks.
Slovenian: Zmanjšanje BMD v kolku je bilo do 96 tednov značilno večje v tej skupini.
English: Therefore, a multidisciplinary approach is recommended to adequately weigh on a case by case basis the benefit/risk balance of treatment, decide the appropriate monitoring during treatment (including decision for treatment withdrawal) and consider the need for supplementation.
Slovenian: Zato se priporoča multidisciplinarni pristop za ustrezno oceno razmerja med koristmi in tveganji zdravljenja, odločitev o ustreznem spremljanju med zdravljenjem (vključno z odločitvijo o prekinitvi zdravljenja) in razmislek o potrebi po dodatku za vsak posamični primer posebej.
English: Demographic characteristics
Slovenian: Demografske značilnosti
English: Mean age was 15 years (range, 12−17), 70% were male, 68% black, 28% Asian.
Slovenian: Povprečna starost je bila 15 let (razpon 12−17), 70 % je bilo moških, 68 % je bilo črncev, 28 % Azijcev.
English: Your doctor will carefully consider whether to treat you with Stribild.
Slovenian: Vaš zdravnik bo skrbno pretehtal, ali naj vas zdravil z zdravilom Stribild.
English: BMD Z-scores were not adjusted for height and weight.
Slovenian: Z-vrednost BMD ni bila prilagojena za višino in telesno maso.
English: If you are older than this and are prescribed Stribild, your doctor will monitor you carefully.
Slovenian: Če ste starejši in so vam predpisali zdravilo Stribild, vas bo zdravnik skrbno nadzoroval.
English: Rarely, cases of pancreatitis and lactic acidosis, sometimes fatal, have been reported.
Slovenian: Redko so poročali o primerih pankreatitisa in laktacidoze, ki so bili včasih smrtni.
English: 2T = second trimester; 3T = third trimester; PP =postpartum a paired comparisons b P<0.10 compared with postpartum
Slovenian: 2T = drugi trimester; 3T = tretji trimester; PP = poporodno obdobje a sparjena primerjava b P < 0,10 v primerjavi s poporodnim obdobjem
English: 6 Study conducted with additional voxilaprevir 100 mg to achieve voxilaprevir exposures expected in HCV-infected patients.
Slovenian: 6 Študijo so izvedli z dodatnim voksilaprevirjem 100 mg za doseganje izpostavljenosti voksilaprevirju, ki se pričakuje pri bolnikih z okužbo s HCV.
English: osteomalacia (manifested as bone pain and infrequently contributing to fractures)1,3,5, myopathy1,3
Slovenian: osteomalacija (ki se kaže kot bolečine v kosteh in redko prispeva k zlomom)1,3,5, miopatija1,3
English: Tell your doctor or pharmacist if you are taking any other medicines or have recently taken any.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katero koli drugo zdravilo.
English: As a result, the amounts of Stribild or other medicines in your blood may be affected.
Slovenian: To lahko posledično vpliva na količino zdravila Stribild ali drugih zdravil v vaši krvi.
English: d Includes patients who discontinued due to adverse event or death at any time point from day 1 through the time window if this resulted in no virologic data on treatment during the specified window.
Slovenian: d Vključuje bolnike, ki so prenehali sodelovati zaradi neželenih učinkov ali smrti, kadar koli od 1. dne do konca časovnega okna, če zaradi tega v določenem oknu ni bilo viroloških podatkov o zdravljenju.
English: • anaemia (low red blood cell count)
Slovenian: • anemija (nizko število rdečih krvnih celic)
English: It is also important to tell your doctor if you are taking any of the following types of medicines:
Slovenian: Pomembno je tudi, da zdravniku poveste, če jemljete katero od naslednjih vrst zdravil:
English: The film-coated tablet should not be chewed or crushed.
Slovenian: Filmsko obložene tablete ni dovoljeno žvečiti ali zdrobiti.
English: • changes to your urine
Slovenian: • spremembe urina
English: If you are affected while taking Stribild, do not drive and do not use any tools or machines.
Slovenian: Če se vam v času zdravljenja z zdravilom Stribild pojavlja kaj od navedenega, ne vozite avtomobila in ne upravljajte z orodji ali stroji.
English: This will improve your immune system and reduce the risk of developing illnesses linked to HIV infection.
Slovenian: S tem se vaš imunski sistem izboljša in zmanjša se tveganje za razvoj bolezni, povezanih z okužbo HIV.
English: e Includes subjects who discontinued for reasons other than an adverse event, death or lack or loss of efficacy, e.g., withdrew consent, loss to follow-up, etc.
Slovenian: e Vključuje osebe, ki so sodelovanje prekinile zaradi drugih razlogov, kot so neželeni učinki, smrt ali pomanjkanje ali izguba učinka, npr. umik soglasja, izgubljeni za spremljanje itd.
English: Both emtricitabine and tenofovir have activity that is specific to human immunodeficiency virus (HIV-1 and HIV-2) and hepatitis B virus.
Slovenian: Tako emtricitabin kot tenofovir imata aktivnost, ki je specifična za virus humane imunske pomanjkljivosti (HIV-1 in HIV-2) in virus hepatitisa B.
English: Adults and adolescents aged 12 years and older weighing at least 35 kg: One tablet, once daily with food.
Slovenian: Odrasli in mladostniki, starih 12 let in več, ki tehtajo vsaj 35 kg: ena tableta enkrat dnevno s hrano.
English: Stribild has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Stribid nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: Alternative endothelin receptor antagonists may be considered.
Slovenian: Razmisli se lahko o alternativnih antagonistih receptorjev endotelina.
English: • increased levels of creatine kinase in the blood that may result in muscle pain and weakness
Slovenian: • zvišanje količine kreatin kinaze v krvi, ki lahko povzročijo bolečine in oslabelost mišic
English: Clinical monitoring is recommended due to the potential for hyperkalemia.
Slovenian: Priporočeno je klinično spremljanje zaradi možnosti hiperkaliemije.
English: • low white blood cell count (which can make you more prone to infection)
Slovenian: • nizko število belih krvnih telesc (kar lahko povzroči večjo nagnjenost k okužbam)
English: Due to limitations of the study, a benefit of tenofovir disoproxil over placebo was not demonstrated based on plasma HIV-1 RNA levels at week 24.
Slovenian: Zaradi omejitev študije korist dizoproksiltenofovirata glede na placebo ni bila dokazana na podlagi plazemskih ravni RNA HIV-1 v 24. tednu.
English: hepatic steatosis1, hepatitis1
Slovenian: hepatična steatoza1, hepatitis1
English: Stribild is not usually taken with other medicines that can damage your kidneys (see Other medicines and Stribild).
Slovenian: Zdravila Stribild se ponavadi ne jemlje z drugimi zdravili, ki bi lahko poškodovala ledvice (glejte Druga zdravila in zdravilo Stribild).
English: It is especially important to talk to your doctor if you are taking any of the following:
Slovenian: Posebno pomembno je, da zdravniku poveste, če jemljete kaj od naslednjega:
English: Tenofovir is primarily excreted by the kidney by both filtration and an active tubular transport system (human organic anion transporter [hOAT1]) with approximately 70-80% of the dose excreted unchanged in urine following intravenous administration.
Slovenian: Tenofovir se primarno izloča preko ledvic tako s filtracijo kot z aktivnim tubularnim transportnim sistemom (humani prenašalec organskih anionov [hOAT1]), pri čemer se po intravenskem vnosu približno 70-80 % odmerka izloči nespremenjenega z urinom.
English: However, a large amount of data in pregnant women (more than1,000 pregnancy outcomes) indicate no malformations or foetal/neonatal toxicity associated with emtricitabine and tenofovir disoproxil.
Slovenian: Vendar pa večje število podatkov pri nosečnicah (več kot 1.000 izpostavljenih nosečnosti) ne kaže na malformacije ali feto/neonatalno toksičnost, povezane z emtricitabinom in dizoproksiltenofoviratom.
English: If you vomit less than 1 hour after taking Stribild, take another tablet with food.
Slovenian: Če bruhate manj kot 1 uro po zaužitju zdravila Stribild, vzemite še eno tableto s hrano.
English: The Marketing Authorisation Holder (MAH) shall ensure that all physicians who are expected to prescribe/use Stribild in adolescent patients are provided with a physician educational pack containing the following:
Slovenian: Imetnik dovoljenja za promet z zdravilom bo zagotovil, da bodo vsi zdravniki, za katere se pričakuje, da bodo predpisovali/uporabljali zdravilo Stribild pri mladostnikih, prejeli izobraževalni paket za zdravnika, ki bo vseboval:
English: The transporters that cobicistat inhibits include P-gp, BCRP, OATP1B1 and OATP1B3.
Slovenian: Transporterji, ki jih kobicistat zavira, vključujejo P-gp, BCRP, OATP1B1 in OATP1B3.
English: If you have HIV infection and hepatitis B, it is especially important not to stop your Stribild treatment without talking to your doctor first.
Slovenian: Če ste okuženi z virusom HIV in hepatitisom B, je še zlasti pomembno, da ne prenehate z zdravljenjem z zdravilom Stribild, ne da bi se prej posvetovali z zdravnikom.
English: The interactions described are based on studies conducted with the components of Stribild as individual agents and/or in combination, or are potential drug interactions that may occur with Stribild.
Slovenian: Opisane interakcije temeljijo na študijah, izvedenih z učinkovinami zdravila Stribild kot posamičnimi učinkovinami in/ali v kombinaciji, ali pa so možne interakcije z zdravili, ki se lahko pojavijo z zdravilom Stribild.
English: • lactic acidosis (see Possible serious side effects: tell a doctor immediately)
Slovenian: • laktacidoza (glejte Možni resni neželeni učinki: takoj obvestite svojega zdravnika)
English: Possible serious side effects: tell a doctor immediately
Slovenian: Možni resni neželeni učinki: takoj obvestite zdravnika
English: • passing a lot of urine and feeling thirsty (nephrogenic diabetes insipidus)
Slovenian: • izločanje večjih količin urina in občutek žeje (nefrogeni diabetes insipidus)
English: • Children given emtricitabine very commonly experienced changes in skin colour including darkening of the skin in patches
Slovenian: • Pri otrocih, ki so dobivali emtricitabin, so se zelo pogosto pojavile spremembe barve kože, vključno s - potemnitvijo kože v zaplatah
English: Eighteen of these 20 patients maintained virologic suppression through 48 weeks.
Slovenian: Osemnajst od teh 20 bolnikov je ohranilo virusno supresijo do vključno konca 48. tedna.
English: Stribild should be taken orally, once daily with food (see section 5.2).
Slovenian: Zdravilo Stribild se jemlje enkrat dnevno, peroralno s hrano (glejte poglavje 5.2).
English: 4 Study conducted using Stribild.
Slovenian: 4 Študija opravljena z zdravilom Stribild.
English: If you take more Stribild than you should
Slovenian: Če ste vzeli večji odmerek zdravila Stribild, kot bi smeli
English: Insufficient safety data are available for children below 12 years of age.
Slovenian: Za otroke stare do 12 let so podatki o varnosti nezadostni.
English: Stribild is a single tablet regimen for the treatment of human immunodeficiency virus (HIV) infection in adults.
Slovenian: Zdravilo Stribild je režim ene same tablete za zdravljenje okužbe z virusom humane imunske pomanjkljivosti (HIV) pri odraslih.
English: Aromatic and aliphatic hydroxylation or glucuronidation metabolites are present in very low levels, display considerably lower anti-HIV activity and do not contribute to the overall antiviral activity of elvitegravir.
Slovenian: Aromatski in alifatski presnovki hidroksilacije ali presnovki glukuronidacije so prisotni v zelo nizkih ravneh, kar kaže na znatno nižjo aktivnost proti HIV in ne prispeva k splošni protivirusni aktivnosti elvitegravirja.
English: Each tablet contains 10.9 mg lactose (as monohydrate).
Slovenian: Ena tableta vsebuje 10,9 mg laktoze (v obliki laktoze monohidrata).
English: Disopyramide Flecainide Systemic lidocaine Mexiletine Propafenone
Slovenian: dizopiramid flekainid sistemski lidokain meksilitin propafenon
English: The MAH must agree the content and format of the medical educational pack with the national competent authority in each Member State prior to its distribution in their territory.
Slovenian: Pred razdeljevanjem izobraževalnega paketa se mora imetnik dovoljenja za promet z zdravilom z nacionalno pristojnim organom v vsakih državi članici pred distribucijo zdravila na svojem ozemlju dogovoriti o vsebini in obliki medicinskega izobraževalnega paketa.
English: See also under Co-administration of other medicinal products below.
Slovenian: Glejte tudi Sočasna uporaba drugih zdravil spodaj.
English: Stribild is not to be given with other antiretroviral medicinal products.
Slovenian: Zdravila Stribild ni dovoljeno uporabljati z drugimi protiretrovirusnimi zdravili.
English: • and you notice within 18 hours of the time you usually take Stribild, you must take the tablet as soon as possible.
Slovenian: • in to opazite v roku 18 ur od časa, ko zdravilo Stribild običajno vzamete, morate tableto vzeti čim prej.
English: The EC50 values for tenofovir were in the range of 0.04 to 8.5 µM.
Slovenian: Vrednosti EC50 za tenofovir so bile v razponu od 0,04 do 8,5 µM.
English: • difficulty sleeping (insomnia), abnormal dreams
Slovenian: • težave s spanjem (nespečnost), nenavadne sanje
English: 2 Anaemia was common and skin discolouration (increased pigmentation) was very common when emtricitabine was administered to paediatric patients.
Slovenian: 2 Anemija je bila pogosta in sprememba obarvanosti kože (povečana pigmentacija) zelo pogosta pri pediatričnih bolnikih ob jemanju emtricitabina.
English: increased transaminases1, hyperbilirubinaemia1
Slovenian: povišanje transaminaz1, hiperbilirubinemija1
English: Do not give this medicine to children under 12 years of age.
Slovenian: Otrokom, starim manj kot 12 let, ne dajajte tega zdravila.
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Slovenian: Če opazite katere koli simptome okužbe ali druge simptome, kot so oslabelost mišic, oslabelost, ki se začne v dlaneh in stopalih in se premika proti trupu, palpitacije, tresavico ali hiperaktivnost, o tem takoj obvestite svojega zdravnika, ki vas bo ustrezno zdravil.
English: Long term oral carcinogenicity studies with elvitegravir and cobicistat did not show any carcinogenic potential in mice and rats.
Slovenian: Dolgoročne študije peroralne kancerogenosti z elvitegravirjem in kobicistatom niso pokazale kancerogenega potenciala pri miših in podganah.
English: • damage to kidney tubule cells
Slovenian: • poškodba celic ledvičnih tubulov
English: Effects on drug levels Mean percent change in AUC, Cmax,
Slovenian: Učinki na koncentracije učinkovin Srednja sprememba AUC, Cmax,
English: Lactic acidosis occurs more often in women - particularly if they are overweight and in people with liver disease.
Slovenian: Laktacidoza se pogosteje pojavi pri ženskah, zlasti tistih s prekomerno telesno maso in pri ljudeh z jetrno boleznijo.
English: An assessment of benefit/risk ratio is recommended to justify use of voriconazole with Stribild.
Slovenian: Priporoča se ocena razmerja med koristmi in tveganji, ki bi upravičila uporabo vorikonazola z zdravilom Stribild.
English: Seven patients had estimated glomerular filtration rate (GFR) values between 70 and 90 mL/min/1.73 m2.
Slovenian: Sedem bolnikov je imelo ocenjene vrednosti hitrosti glomerularne filtracije (GFR- glomerular filtration rate) med 70 in 90 ml/min/1,73 m2.
English: If you forget to take Stribild
Slovenian: Če ste pozabili vzeti zdravilo Stribild
English: The dual-drug combinations and the triple combination of elvitegravir, emtricitabine and tenofovir demonstrated synergistic activity in cell culture.
Slovenian: Kombinacija dveh zdravil in trojna kombinacija elvitegravirja, emtricitabina in tenofovirja je pokazala sinergijsko aktivnost v celični kulturi.
English: • If you have liver problems or a history of liver disease, including hepatitis.
Slovenian: • Če imate težave z jetri ali jetrne bolezni v anamnezi, vključno s hepatitisom.
English: this may cause the child to be tired or breathless
Slovenian: - to lahko povzroči utrujenost ali zasoplost otroka
English: • If you stopped treatment with any medicine containing tenofovir disoproxil on the advice of your doctor following problems with your kidney function.
Slovenian: • Če ste se prenehali zdraviti s katerim koli zdravilom, ki vsebuje dizoproksiltenofovirat po nasvetu zdravnika zaradi težav, ki so nastopile z delovanjem ledvic.
English: For information on other acid reducing agents (e.g. H2-receptor antagonists and proton pump inhibitors), see Studies conducted with other medicinal products.
Slovenian: Za informacije o drugih zdravilih, ki zmanjšujejo kislino (npr. antagonisti receptorja H2 in zaviralci protonske črpalke) glejte Študije, opravljene z drugimi zdravili.
English: Primary mutations for raltegravir/elvitegravir do not affect the in vitro susceptibility of dolutegravir as single mutations, and the additional presence of secondary mutations (except Q148) also does not result in relevant fold changes in experiments with site directed mutants.
Slovenian: Primarne mutacije za raltegravir/elvitegravir kot enkratne mutacije ne vplivajo na dovzetnost za dolutegravir in vitro, dodatna prisotnost sekundarnih mutacij (razen Q148) pa prav tako ni povzročila pomembnih sprememb stopenj v poskusih s točkovnimi mutanti.
English: Renal and bone effects in adults
Slovenian: Učinki na ledvice in kosti pri odraslih
English: Pharmacotherapeutic group: Antivirals for systemic use; antivirals for treatment of HIV infections, combinations.
Slovenian: Farmakoterapevtska skupina: Sistemski virostatiki; zdravila za sistemsko zdravljenje virusnih infekcij (HIV), kombinacije.
English: The effects of tenofovir disoproxil-associated changes in BMD on long-term bone health and future fracture risk are currently unknown (see section 5.1).
Slovenian: Učinki sprememb BMD zaradi dizoproksiltenofovirata na dolgoročno zdravje kosti in tveganje za zlome v prihodnje trenutno niso znani (glejte poglavje 5.1).
English: • increased sugar, fatty acids (triglycerides), bilirubin in your blood
Slovenian: • povišanje količine sladkorja, maščobnih kislin (trigliceridi), bilirubina v krvi
English: Relative to fasting conditions, the administration of Stribild with a light meal (~373 kcal, 20% fat) or high-fat meal (~800 kcal, 50% fat) resulted in increased exposures of elvitegravir and tenofovir.
Slovenian: Relativno glede na pogoje na tešče je dajanje zdravila Stribild z lahkim obrokom (~373 kcal, 20 % maščobe) ali obrokom z visoko vsebnostjo maščobe (~800 kcal, 50 % maščobe) povzročilo povečanje izpostavljenosti elvitegravirju in tenofovirju.
English: • Children commonly experienced low red blood cell count (anaemia).
Slovenian: • Otroci so imeli pogosto nizko število rdečih krvničk (anemija).
English: If concomitant use of Stribild and nephrotoxic agents is unavoidable, renal function must be monitored weekly.
Slovenian: Če je sočasna uporaba zdravila Stribild in nefrotoksičnih zdravil neizogibna, je treba tedensko spremljati ledvično funkcijo.
English: Stribild has not been studied in patients over 65 years of age.
Slovenian: Zdravila Stribild niso proučevali pri bolnikih, starejših od 65 let.
English: Stribild may interact with other medicines.
Slovenian: Zdravilo Stribild lahko medsebojno deluje z drugimi zdravili.
English: If Stribild is stopped for any reason, speak to your doctor before you restart taking Stribild tablets.
Slovenian: Če zaradi katerega koli razloga prenehate jemati zdravilo Stribild, se pogovorite z zdravnikom, preden začnete ponovno jemati tablete zdravila Stribild.
English: 4 See section 4.8, Description of selected adverse reactions for more details.
Slovenian: 4 Za več podrobnosti glejte poglavje 4.8 Opis izbranih neželenih učinkov.
English: • If you have kidney problems, or have had kidney problems, or if tests have shown problems with your kidneys.
Slovenian: • Če imate težave z ledvicami ali ste kdaj prej imeli težave z ledvicami ali če so preiskave kazale na težave z ledvicami.
English: Interrupting treatment with Stribild should also be considered in case of progressive decline of renal function when no other cause has been identified.
Slovenian: O prekinitvi zdravljenja z zdravilom Stribild je treba razmisliti tudi v primeru progresivnega upada ledvične funkcije, če ni bil ugotovljen noben drug vzrok.
English: • Use effective contraception while taking Stribild.
Slovenian: • Med jemanjem zdravila Stribild uporabljajte učinkovito kontracepcijo.
English: Renal and bone effects in the paediatric population
Slovenian: Učinki na ledvice in kosti pri pediatrični populaciji
English: Tenofovir disoproxil had no effect on any of the CYP450 isoforms, except CYP1A1/2, where a small (6%) but statistically significant reduction in metabolism of a CYP1A1/2 substrate was observed.
Slovenian: Dizoproksiltenofovirat ni imel učinka na nobeno od izooblik CYP450, razen na CYP1A1/2, kjer so opazili majhno (6 %), a statistično značilno zmanjšanje presnove substrata CYP1A1/2.
English: The substitutions that emerged were M184V/I (n = 17) and K65R (n = 5) in reverse transcriptase and E92Q (n = 9), N155H (n = 5), Q148R (n = 3), T66I (n = 2), and T97A (n = 1) in integrase.
Slovenian: Substitucije, ki so se pojavile, so bile M184V/I (n = 17) in K65R (n = 5) reverzne transkriptaze in E92Q (n = 9), N155H (n = 5), Q148R (n = 3), T66I (n = 2) in T97A (n = 1) integraze.
English: Of the 18 patients with viral resistance development, 13 occurred through Week 48, 3 occurred between Week 48 to Week 96, and 2 occurred between Week 96 to Week 144 of treatment.
Slovenian: Od 18 bolnikov z razvojem rezistence na virus se jih je 13 pojavilo v prvih 48 tednih, 3 so se pojavile od 48. tedna do 96. tedna in 2 sta se pojavili od 96. tedna do 144. tedna zdravljenja.
English: In other studies (prospective and cross-sectional), the most pronounced decreases in BMD were seen in patients treated with tenofovir disoproxil as part of a regimen containing a boosted protease inhibitor.
Slovenian: V drugih študijah (prospektivne in presečne) so najbolj izrazito zmanjšanje BMD opazili pri bolnikih, zdravljenih z dizoproksiltenofoviratom kot del režima, ki je vseboval okrepljenega zaviralca proteaze.