FrancophonIA/ELRC3.0 huggingface dataset:
English: - Lithium: NSAIDs inhibit renal clearance of lithium, thus the serum concentration of lithium may increase above toxicity limits.
Slovenian: - Litij: Nesteroidna protivnetna zdravila zavirajo očistek litija, zato se lahko serumske koncentracije litija zvišajo nad mejno vrednost toksičnosti.
English: Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development.
Slovenian: Zaviranje sinteze prostaglandinov lahko škodljivo vpliva na nosečnost ali razvoj zarodka/ploda ali oboje.
English: Posology - Section 4.2
Slovenian: Odmerjanje - poglavje 4.2
English: Xefo Rapid may interfere with other medicines.
Slovenian: Zdravilo Xefo Rapid lahko vpliva na delovanje drugih zdravil.
English: Low 8mg 12mg 16mg High Total Low 8mg 12mg 16mg High TotalTotal
Slovenian: Indikacija odmerek lornoksikama nizek 8 mg 12 mg 16 mg viso k skupn o nizek 8 mg 12 mg 16 mg visok skup no skupno
English: Concomitant treatment with NSAIDs and heparin in the context of a spinal or epidural anaesthesia increases the risk of spinal/epidural haematoma (see section 4.5).
Slovenian: Sočasno zdravljenje z nesteroidnimi protivnetnimi zdravili in heparinom v primeru spinalne ali epiduralne anestezije zviša tveganje nastanka spinalnega/epiduralnega hematoma (glejte poglavje 4.5).
English: Less frequently, gastritis has been observed.
Slovenian: Redkejša so poročila o pojavu gastritisa.
English: Similarly an initially oral dose of 16 mg lornoxicam given in study LD-030-IN was followed by 8 mg as a second dose on day one and found to be effective and safe in patients with acute low back pain.
Slovenian: Podobno je začetnemu peroralnemu odmerku 16 mg lornoksikama v raziskavi LD-030-IN sledilo 8 mg kot drugi odmerek prvi dan, kar se je izkazalo za učinkovito in varno pri bolnikih z akutnimi bolečinami v spodnjem delu hrbta.
English: Reconstituted solution: Chemical and physical in-use stability has been demonstrated for 24 hours at 21°C (±2°C).
Slovenian: Pripravljena raztopina: Dokazano je, da so kemijske in fizikalne lastnosti zdravila med uporabo stabilne 24 ur pri 21 °C (± 2 °C).
English: The Cmax for Xefo Rapid filmcoated tablets is higher than Cmax for Xefo film-coated tablets and equivalent to Cmax for the parenteral formulation of lornoxicam.
Slovenian: Cmax za zdravilo Xefo Rapid filmsko obložene tablete je višja kot Cmax za zdravilo Xefo filmsko obložene tablete in enakovredna Cmax za parenteralno obliko lornoksikama.
English: The Table below shows the percentages of patients with ADRs in order of incidence by system organ classification (SOC, WHO), lornoxicam dose and indication.
Slovenian: V spodnji tabeli so prikazani deleži bolnikov z neželenimi učinki zdravila po vrstnem redu pogostosti glede na klasifikacijo organskega sistema (OS, SZO), odmerek lornoksikama in indikacijo.
English: 6.3 Shelf life 2 years.
Slovenian: 6.3 Rok uporabnosti 2 leti
English: The dose-recommendations in the SPC for the 8 mg filmcoated tablets are supported by the presented data.
Slovenian: Priporočene odmerke v SPC za 8 mg filmsko obložene tablete potrjujejo predloženi podatki.
English: Pack sizes: 1, 5, 6, 10 sets.
Slovenian: Pakiranja: 1, 5, 6, 10 kompletov.
English: Solvent for solution for injection Water for injections i.v.
Slovenian: voda za injekcije i.v.
English: Rare: Dyspnoea, cough, bronchospasm.
Slovenian: Redki: dispneja, kašelj, bronhospazem.
English: If you have heart problems, previous stroke or think that you might be at risk of theese conditions (for example if you have high blood pressure, diabetes or high cholesterol or are a smoker) you should discuss your treatment with your doctor or pharmacist.
Slovenian: Če imate težave s srcem, ste imeli možgansko kap ali menite, da ste v nevarnosti zaradi teh dveh bolezni (npr. imate zvišan krvni tlak, sladkorno bolezen, visoke ravni holesterola ali kadite), se morate o zdravljenju posvetovati s svojim zdravnikom ali farmacevtom.
English: When concomitant therapy has to be used careful monitoring should be undertaken.
Slovenian: Če je treba izvajati sočasno zdravljenje, je potrebno spremljanje.
English: Study reference no.
Slovenian: Referenčna št. raziskave
English: 8 mg Film-coated tablet
Slovenian: 8 mg Filmsko obložena tableta
English: 6 film-coated tablets 10 film-coated tablets 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 100 film-coated tablets 250 film-coated tablets
Slovenian: 6 filmsko obloženih tablet 10 filmsko obloženih tablet 20 filmsko obloženih tablet 30 filmsko obloženih tablet 50 filmsko obloženih tablet 100 filmsko obloženih tablet 250 filmsko obloženih tablet
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, and carcinogenic potential.
Slovenian: Neklinični podatki na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih, genotoksičnosti in kancerogenega potenciala ne kažejo posebnega tveganja za človeka.
English: Tablet container: This medicinal product does not require any special storage conditions
Slovenian: Vsebnik za tablete: Za shranjevanje zdravila niso potrebna posebna navodila.
English: In rabbit and rat, lornoxicam caused premature closure of the ductus arteriosus due to inhibition of cyclooxygenase.
Slovenian: Pri kuncih in podganah je lornoksikam povzročil prezgodno zaprtje arterioznega duktusa zaradi zaviranja ciklooksigenaze.
English: Cardiovascular
Slovenian: Kardiovaskularni
English: For all the pharmaceutical forms and strengths of lornoxicam The following wording has been included as agreed by the PhVWP in October 2005 and January
Slovenian: Za vse farmacevtske oblike in jakosti lornoksikama V skladu z dogovorom, doseženim v delovni skupini PhVWP oktobra 2005 in januarja 2007, je bilo vključeno naslednje besedilo:
English: Initial recommended dose is 12 mg lornoxicam daily divided into 2 or 3 doses.
Slovenian: Začetni priporočeni odmerek je 12 mg lornoksikama na dan, porazdeljenega v 2 ali 3 odmerke.
English: Rare: Confusion, nervousness, agitation.
Slovenian: Redki: konfuznost, živčnost, agitiranost.
English: What Xefo Rapid is and what it is used for Before you take Xefo Rapid How to take Xefo Rapid Possible side effects
Slovenian: Kaj je zdravilo Xefo Rapid in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Xefo Rapid Kako jemati zdravilo Xefo Rapid Možni neželeni učinki
English: Patients showing dizziness and/or sleepiness under treatment with lornoxicam should refrain from driving or operation machinary.
Slovenian: Bolniki, ki med zdravljenjem z lornoksikamom občutijo omotico in/ali zaspanost, ne smejo voziti ali upravljati s stroji.
English: Lornoxicam should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
Slovenian: Zdravljenje z zdravilom Lornoxicam morate prekiniti ob prvem pojavu kožnih izpuščajev, lezij na sluznicah ali drugih znakov preobčutljivostne reakcije.
English: Lornoxicam is available as film coated tablets 4 mg and 8 mg, rapid release film-coated tablets 8 mg, and as powder and solvent for solution for injection 4 mg/ml for intramuscular and intravenous injection.
Slovenian: Lornoksikam je na voljo v obliki filmsko obloženih tablet 4 mg in 8 mg, filmsko obloženih tablet 8 mg s hitrim sproščanjem ter v obliki praška in vehikla za pripravo raztopine za injiciranje 4 mg/ml za intramuskularno in intravensko injiciranje.
English: Meta-analysis 3:
Slovenian: 3. metaanaliza:
English: 4 mg Film-coated tablet
Slovenian: 4 mg Filmsko obložena tableta
English: - Anti-coagulants: NSAIDs may enhance the effects of anti-coagulants, such as warfarin (see section 4.4).
Slovenian: - Antikoagulanti: Nesteroidna protivnetna zdravila lahko povečajo učinek antikoagulantov, npr. varfarina (glejte poglavje 4.4).
English: Study CT85 used only a single oral dose of 8 mg LNX p.o.
Slovenian: V raziskavi CT85 so bili uporabljeni samo enkratni peroralni odmerki 8 mg lornoksikama p.o.
English: There is no significant change in the kinetic profile of lornoxicam in patients with renal or hepatic failure, except for accumulation in patients with chronic liver disease after 7 days of treatment with daily doses of 12 and 16 mg.
Slovenian: Pomembnih razlik v kinetičnem profilu lornoksikama pri bolnikih z odpovedovanjem ledvic ali jeter ni, razen akumulacije pri bolnikih s kronično jetrno boleznijo po 7 dneh zdravljenja z dnevnim odmerkom 12 ali 16 mg.
English: - the scope of the referral was the harmonisation of the Summaries of Products Characteristics, labelling and package leaflet.
Slovenian: - Namen napotitve je bil usklajevanje Povzetkov glavnih značilnosti zdravila, označevanja in Navodila za uporabo.
English: Gastrointestinal bleeding, ulceration and perforation: GI bleeding, ulceration or perforation, which can be fatal, has been reported with all NSAIDs at anytime during treatment, with or without warning symptoms or a previous history of serious GI events.
Slovenian: Gastrointestinalna krvavitev, ulkus in perforacije: o gastrointestinalni krvavitvi, ulkusu in perforaciji, ki utegnejo biti usodni, so poročali pri vseh NSAID kadar koli med zdravljenjem, z opozorilnimi simptomi ali anamnezo resnih gastrointestinalnih dogodkov ali brez njih.
English: Lornoxicam is contraindicated on the third trimester of pregnancy and should not be used during pregnancy in the first and second trimesters and delivery as no clinical data on exposed pregnancies are available.
Slovenian: Lornoksikam je kontraindiciran v tretjem trimesečju nosečnosti in se naj nebi uporabljal med nosečnostjo v prvem in drugem trimesečju in pri porodu, saj klinični podatki o uporabi med nosečnostjo niso na voljo.
English: In a clinical study in patients with pain after surgical removal of an impacted third molar lornoxicam Rapid film-coated tablets showed a faster onset of action compared to lornoxicam film-coated tablets.
Slovenian: V klinični študiji pri bolnikih z bolečino po kirurški odstranitvi zagozdenega tretjega kočnika je zdravilo Xefo Rapid filmsko obložene tablete hitreje začelo delovati v primerjavi z zdravilom Xefo filmsko obložene tablete.
English: 28802 Alcalá de Henares, Madrid, Spain
Slovenian: M-300, Km 30,500. 28802 Alcalá de Henares, Madrid, Španija
English: Lornoxicam, 4 & 8 mg, film-coated tablets 8-16 mg lornoxicam daily divided into 2 or 3 doses.
Slovenian: Lornoksikam, 4 mg in 8 mg, filmsko obložene tablete 8-16 mg lornoksikama dnevno, razdeljeno na 2 ali 3 odmerke.
English: - Cyclosporine: Increased serum concentration of cyclosporine.
Slovenian: - Ciklosporin: Zvišane serumske koncentracije ciklosporina.
English: 4.7 Effects on ability to drive and use machines Patients showing dizziness and/or sleepiness under treatment with lornoxicam should refrain from driving or operation machinery.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja s stroji Bolniki, pri katerih se med zdravljenjem z lornoksikamom pojavi omotica ali zaspanost ali oboje, ne smejo voziti ali upravljati s stroji.
English: Very rare: Oedema and bullous reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis
Slovenian: Zelo redki: edem in mehurjaste reakcije, sindrom Stevens-Johnson, toksična epidermalna nekroliza.
English: Lornoxicam is extensively metabolised in the liver, primarily to the inactive 5-hydroxylornoxicam by hydroxylation.
Slovenian: V jetrih poteka obsežna presnova lornoksikama, zlasti v neaktivni presnovek 5-hidroksilornoksikam z reakcijo hidroksilacije.
English: Common (less than 1 in 10, but more than 1 in 100 patients treated) Mild and transient headache, dizziness, nausea, abdominal pain, dyspepsia, diarrhoea, vomiting.
Slovenian: Pogosti (pri manj kot 1 od 10, vendar pri več kot 1 od 100 zdravljenih bolnikov) Blag in prehoden glavobol, omotica, slabost, trebušne bolečine, prebavne motnje, driska, bruhanje.
English: Concomitant treatment of NSAIDs and tacrolimus may increase the risk of nephrotoxicity owing to reduced synthesis of prostacyclin in the kidney.
Slovenian: Sočasno zdravljenje z nesteroidnimi protivnetnimi zdravili in takrolimusom lahko zviša tveganje nefrotoksičnosti zaradi zmanjšane sinteze prostaciklina v ledvicah.
English: 10 film-coated tablets 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 100 film-coated tablets
Slovenian: 10 filmsko obloženih tablet 20 filmsko obloženih tablet 30 filmsko obloženih tablet 50 filmsko obloženih tablet 100 filmsko obloženih tablet
English: How to store Xefo Rapid Further information
Slovenian: Shranjevanje zdravila Xefo Rapid Dodatne informacije
English: Rare: Hepatic function abnormal.
Slovenian: Redki: nenormalna funkcija jeter.
English: Rheumatology
Slovenian: Revmatologija
English: - Heparin: NSAIDs increase the risk of spinal or epidural haematoma when given concomitantly to heparin in the context of spinal or epidural anaesthesia.
Slovenian: - Heparin: Nesteroidna protivnetna zdravila pri sočasnem dajanju s heparinom zvišajo tveganje nastanka spinalnega ali epiduralnega hematoma v primeru spinalne ali epiduralne anestezije.
English: • Efficacy issues
Slovenian: Vidiki učinkovitosti
English: During combined treatment renal function should be monitored.
Slovenian: Med kombiniranim zdravljenjem je treba spremljati ledvično funkcijo.
English: 4.1 Therapeutic indications - Short-term relief of acute mild to moderate pain - Symptomatic relief of pain and inflammation in osteoarthritis - Symptomatic relief of pain and inflammation in rheumatoid arthritis
Slovenian: 4.1 Terapevtske indikacije - Kratkotrajno lajšanje akutne blage do zmerne bolečine - Simptomatsko lajšanje bolečine in vnetja pri osteoartritisu - Simptomatsko lajšanje bolečine in vnetja pri revmatoidnem artritisu
English: After the first treatment day the maximum recommended daily dose is 16 mg.
Slovenian: Po prvem dnevu zdravljenja je največji priporočeni dnevni odmerek 16 mg.
English: In women who have difficulties conceiving, or who are undergoing investigation of infertility, withdrawal of Xefo should be considered.
Slovenian: Pri ženskah, ki imajo težave pri zanositvi ali opravljajo preiskave zaradi neplodnosti, je treba preučiti prekinitev zdravljenja z zdravilom Xefo.
English: Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs (see section 4.8).
Slovenian: V zelo redkih primerih so opazili hude kožne reakcije (med katerimi so imele nekatere smrtni izid), med drugim eksfoliativni dermatitis, sindrom Stevens-Johnson in toksično epidermalno nekrolizo, ki so bile povezane z uporabo nesteroidnih protivnetnih zdravil (glejte poglavje 4.8).
English: In case of an overdose the following symptoms may be expected: Nausea, vomiting, cerebral symptoms (dizziness, disturbances in vision).
Slovenian: V primeru prevelikega odmerjanja lahko pričakujete naslednje simptome: slabost, bruhanje, možganski simptomi (omotica, motnje vida).
English: In the case of a real or suspected overdose, the medication should be withdrawn.
Slovenian: V primeru prevelikega odmerjanja ali suma nanj moramo prekiniti zdravljenje.
English: In women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of lornoxicam should be considered.
Slovenian: Pri ženskah, ki imajo težave pri zanositvi ali opravljajo preiskave zaradi neplodnosti, je treba preučiti prekinitev zdravljenja z lornoksikamom.
English: The meta-analysis included only 3 studies on third molar surgery (CT01, CT14, CT78) with orally applied lornoxicam.
Slovenian: Metaanaliza je obsegala samo 3 raziskave o operativni odstranitvi modrostnih zob (CT01, CT14, CT78), pri katerih je bil lornoksikam dajan peroralno.
English: Lornoxicam is not dialysable.
Slovenian: Lornoksikam se ne odstranjuje z dializo.
English: NSAIDs should be given with care to patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease) as their condition may be exacerbated (see section 4.8).
Slovenian: Nesteroidna protivnetna zdravila morate previdno dajati bolnikom z anamnezo gastrointestinalnih bolezni (ulcerativni kolitis, Crohnova bolezen), saj lahko poslabšajo bolezensko stanje (glejte poglavje 4.8).
English: Based on principles, only administering activated charcoal immediately after the intake of lornoxicam can lead to diminished absorption of the preparation.
Slovenian: Načeloma lahko zmanjšanje absorpcije lornoksikama dosežemo le z dajanjem aktivnega oglja neposredno po zaužitju pripravka.
English: - Renal functions should be monitored in patients who undergo major surgery, with cardiac failure, receiving treatment with diuretics, receiving concomitant treatment with drugs that are suspected to or known to be able to cause kidney damage.
Slovenian: - Ledvično funkcijo morate spremljati pri bolnikih po večjih kirurških posegih, bolnikih s srčnim popuščanjem, bolnikih, ki se zdravijo z diuretiki ali sočasno jemljejo zdravila, ki nedokazano ali dokazano poškodujejo ledvice.
English: Like all medicines, Xefo Rapid can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Xefo Rapid neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Rare: Somnolence, paraesthesia, dysgeusia, tremor, migraine.
Slovenian: Redki: somnolenca, parestezija, motnje okušanja, tremor, migrena.
English: The overall serious ADR (SADR) incidence for lornoxicam was 0.6%.
Slovenian: Celokupna pogostost resnih neželenih učinkov zdravila za lornoksikam je bila 0,6 %.
English: METHOD OF ADMINISTRATION The powder must be dissolved in the accompanying solvent before use.
Slovenian: POSTOPEK UPORABE Pred uporabo morate prašek raztopiti v priloženem vehiklu.
English: Xefo 4 mg/ml solution for injection is intended for intramuscular (i.m.)
Slovenian: Zdravilo Xefo 4 mg/ml raztopina za injiciranje je namenjeno intramuskularni (i.m.)
English: It is intended for short term relief of acute mild to moderate pain and symptomatic relief of pain and inflammation in rheumatoid arthritis and osteoarthritis.
Slovenian: Namenjeno je kratkotrajnemu lajšanju akutne blage do zmerne bolečine ter simptomatskemu lajšanju bolečine in vnetja pri revmatskem artritisu in osteoartritisa.
English: Like all medicines, Xefo can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Xefo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Eleven studies with lornoxicam were performed in patients suffering from rheumatoid arthritis (RA) including nine controlled and 2 uncontrolled clinical phase II or III studies in RA patients.
Slovenian: Terapevtska indikacija - revmatske bolečine (RA) Izvedenih je bilo enajst raziskav z lornoksikamom na bolnikih z revmatoidnim artritisom (RA), vključno z devetimi kontroliranimi in dvema nekontroliranima kliničnima raziskavama II.
English: Patients with uncontrolled hypertension, congestive heart failure, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease should only be treated with Lornoxicam after careful consideration.
Slovenian: Bolnike z nenadzorovano hipertenzijo, kongestivnim srčnim popuščanjem, potrjeno ishemično srčno boleznijo, periferno arterijsko boleznijo in/ali cerebrovaskularno boleznijo je dovoljeno zdraviti z lornoksikamom samo po tehtnem premisleku.
English: - Patients with blood coagulation disorders: Careful clinical monitoring and laboratory assessment is recommended (e.g. APTT).
Slovenian: - Bolniki z boleznimi strjevanja krvi: Priporočamo natančno klinično spremljanje in opravljanje laboratorijskih preiskav (npr. aktivirani parcialni tromboplastinski čas).
English: Severe urinary, CNS and skin reactions have not been reported.
Slovenian: O resnih učinkih na sečila, osrednji živčni sistem in kožnih reakcijah ni poročil.
English: What Xefo looks like and contents of the pack The powder is a yellow, solid substance and the solvent a clear liquid.
Slovenian: Izgled zdravila Xefo in vsebina pakiranja Prašek je rumena, trdna snov.
English: Simultaneous intake of lornoxicam with meals reduces Cmax by approximately 30 % and Tmax increases from 1.5 to 2.3 hours.
Slovenian: Jemanje lornoksikama med obrokom zniža Cmax za približno 30 %, Tmax pa se podaljša iz 1,5 h na 2,3 h. Absorpcija lornoksikama (izračunana na osnovi AUC) se lahko zmanjša za 20 %.
English: 6.4 Special precautions for storage This medicinal product does not require any special storage conditions
Slovenian: 6.4 Posebna navodila za shranjevanje Za shranjevanje zdravila niso potrebna posebna navodila.
English: - Other NSAIDs: Increased risk of gastrointestinal bleeding.
Slovenian: - Druga nesteroidna protivnetna zdravila: Zvišano tveganje gastrointestinalne krvavitve.
English: For patients with moderate hepatic impairment the maximum recommended daily dose is 12 mg divided in 2 or 3 doses (see section 4.4).
Slovenian: Pri bolnikih z zmerno okvaro jeter je največji dnevni odmerek 12 mg, porazdeljen v 2 ali 3 odmerke (glejte poglavje 4.4).
English: Xefo Rapid should not be used concomitantly with other NSAIDs such as acetylsalicylic acid, ibuprofen and COX-2 inhibitors.
Slovenian: Zdravila Xefo Rapid ne smete uporabljati sočasno z drugimi nesteroidnimi protivnetnimi zdravili, kot so acetilsalicilna kislina, ibuprofen in zaviralci COX-2.
English: For i.m.
Slovenian: Za i.m.
English: Xefo may interfere with other medicines.
Slovenian: Zdravilo Xefo lahko vpliva na delovanje drugih zdravil.
English: A clear reduction in pain intensity vs. placebo was only obtained at ≥8 mg LNX p.o. (8
Slovenian: Jasno zmanjšanje intenzivnosti bolečine v primerjavi s placebom je bilo doseženo samo pri ≥8 mg p.o. lornoksikama (8 mg odmerek v raziskavi CT01).
English: Severe symptoms are ataxia ascending to coma and cramps, liver and kidney damages and maybe coagulation disorders.
Slovenian: Resni simptomi so ataksija, ki napreduje do kome in krčev, poškodbe jeter in ledvic ter verjetno tudi motnje strjevanja krvi.
English: In addition the following wording has been included as agreed by the PhVWP in October 2005 and January 2007:
Slovenian: V skladu z dogovorom, doseženim v delovni skupini PhVWP oktobra 2005 in januarja 2007, je bilo dodatno vključeno naslednje besedilo:
English: 1 set contains:
Slovenian: Navodilo vsebuje:
English: Lornoxicam, 8 mg, Powder and solvent for solution for injection Recommended dose: 8 mg intravenous or intramuscular.
Slovenian: Lornoksikam, 8 mg, prašek in vehikel za raztopino za injiciranje Priporočeni odmerek: 8 mg intravensko ali intramuskularno.
English: For patients with mild to moderate renal impairment the maximum recommended daily dose is 12 mg divided in 2 or 3 doses (see section 4.4).
Slovenian: Pri bolnikih z blago do zmerno okvaro ledvic je največji dnevni odmerek 12 mg, porazdeljen v 2 ali 3 odmerke (glejte poglavje 4.4).
English: Incidence of ADRs reported for lornoxicam by SOC, Indication and Dose
Slovenian: Pogostost neželenih učinkov zdravila, o katerih so poročali pri lornoksikamu glede na OS, indikacijo in odmerek
English: Important information about some of the ingredients of Xefo Xefo 8 mg tablets contain lactose monohydrate.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Xefo Xefo 8 mg filmsko obložene tablete vsebujejo laktozo monohidrat.
English: If you are going to be treated with heparin or tacrolimus concomitantly with Xefo, please inform your doctor about your current medicine.
Slovenian: Če vas bodo sočasno z zdravilom Xefo zdravili s heparinom ali takrolimusom, obvestite svojega zdravnika o zdravilu, ki ga jemljete trenutno.
English: No special dosage modification is required for elderly patients above age 65, but Lornoxicam should be administered with precaution as gastrointestinal adverse effects are less well tolerated in this group (see section 4.4).
Slovenian: Za bolnike, starejše od 65 let, ni potrebno prilagajati odmerjanja, vendar pri teh bolnikih zdravilo Lornoxicam dajemo previdno, saj slabše prenašajo gastrointestinalne neželene učinke zdravila (glejte poglavje 4.4).
English: Immune system disorders Rare: Hypersensitivity.
Slovenian: Bolezni imunskega sistema Redki: preobčutljivost.