FrancophonIA/ELRC3.0 huggingface dataset:
English: How to store Sialanar
Croatian: Kako primjenjivati Sialanar
English: If the child is given the medicinal product through a feeding tube, flush the tube with 10 ml of water after you have given the medicinal product.
Croatian: Ako dijete prima lijek putem sonde za hranjenje, nakon što primijenite lijek isperite sondu s 10 ml vode.
English: If your child is given the medicine through a feeding tube, flush the tube with 10 ml of water after you have given the medicine.
Croatian: Ako vaše dijete prima lijek putem sonde (cjevčice) za hranjenje, nakon što primijenite lijek, isperite sondu s 10 ml vode.
English: • Allergic reaction (rash, itching, red raised itchy rash (hives), difficulty breathing or swallowing, dizziness) - frequency not known
Croatian: • Alergijske reakcije (osip, svrbež, crveni ispupčeni osip popraćen svrbežom (koprivnjača), otežano disanje ili gutanje, omaglica) - učestalost nije poznata
English: Glycopyrronium treatment should be withdrawn until the urinary retention resolves.
Croatian: Liječenje glikopironijem treba obustaviti dok ne nestane nuspojava retencije urina.
English: Urinary retention is a known adverse reaction associated with anticholinergic medicinal products (15%).
Croatian: Zadržavanje mokraće je poznata nuspojava povezana s antikolinergičkim lijekovima (15 %).
English: Sialanar acts on the salivary glands to reduce production of saliva.
Croatian: Sialanar djeluje na žlijezde slinovnice i smanjuje stvaranje sline.
English: • Irritability
Croatian: • Razdražljivost
English: Data from sparse PK sampling in children suggests dose proportional PK.
Croatian: Podaci iz oskudnog uzorkovanja farmakokinetičkih svojstava u djece ukazuju na farmakokinetiku lijeka proporcionalnu dozi.
English: In most paediatric subjects, plasma glycopyrronium vs. time plots are reported to show a triexponential curve; adults generally show a biexponential curve.
Croatian: U većine pedijatrijskih bolesnika zabilježena je troeksponencijalna krivulja za glikopironij u plazmi u odnosu na vremenske odsječke; kod odraslih je većinom zabilježena bieksponencijalna krivulja.
English: • Pneumonia (severe chest infection)
Croatian: • Upala pluća (teška infekcija dišnog sustava)
English: Nystagmus
Croatian: Nistagmus
English: Use while breast-feeding is contraindicated (see section 4.3).
Croatian: Primjena tijekom dojenja je kontraindicirana (vidjeti dio 4.3.).
English: The PK of glycopyrronium has been shown to be essentially independent of age in children in the age range 0.19 - 14 years administered a 5 µg/kg i.v.
Croatian: Pokazalo se da farmakokinetika glikopironija u biti ne ovisi o dobi djece u dobnoj skupini između 0,19 i 14 godina koja su intravenski primila jednu dozu od 5 µg/kg.
English: Anticholinergics may delay the gastrointestinal absorption of other anticholinergics administered orally and also increase the risk of anticholinergic side effects.
Croatian: Antikolinergici mogu usporiti gastrointestinalnu apsorpciju drugih antikolinergika za peroralnu primjenu te povećati rizik od antikolinergičkih nuspojava.
English: • urgent need to urinate;
Croatian: • hitna potreba za mokrenjem;
English: Co-administration with food results in a marked decrease in systemic glycopyrronium exposure.
Croatian: Kod istovremenog uzimanja s hranom dolazi do značajnog smanjenja sistemske izloženosti glikopironiju.
English: Each ml of solution contains 400 micrograms glycopyrronium bromide equivalent to 320 micrograms of glycopyrronium.
Croatian: Jedan ml otopine sadrži 400 mikrograma glikopironijeva bromida, što odgovara 320 mikrograma glikopironija.
English: This medicine contains 2.3 mg benzoate salt (E211) in each ml.
Croatian: Ovaj lijek sadrži 2,3 mg soli benzoatne kiseline (E211) u jednom ml.
English: Each ml contains 2.3 mg sodium benzoate (E211).
Croatian: Jedan ml sadrži 2,3 mg natrijeva benzoata (E211).
English: The following medicinal product interaction information is relevant to glycopyrronium.
Croatian: Podaci o interakciji s lijekovima navedeni u nastavku vrijede za glikopironij.
English: • Bad breath (halitosis)
Croatian: • Zadah iz usta (halitoza)
English: Check that you have drawn up the correct level on the syringe before giving Sialanar.
Croatian: Prije davanja lijeka Sialanar provjerite na štrcaljki jeste li navukli lijek do točne razine.
English: (~8.8µg/kg) 1 (~17.6µg/kg) 1 (~27.2µg/kg) 1 (~36µg/kg) 1 (~44.8µg/kg) 1 ml ml ml ml ml
Croatian: (~8,8 µg/kg) 1 (~17,6 µg/kg)
English: • Widening of the pupil of the eye (mydriasis)
Croatian: • Širenje očnih zjenica (midrijaza)
English: The elimination half-life of glycopyrronium appears to be dependent on route of administration being 0.83 ± 0.27 hours after i.v.
Croatian: Čini se da poluvijek eliminacije glikopironija ovisi o načinu primjene i iznosi 0,83 ± 0,27 sati nakon intravenske primjene, 75 minuta nakon intramuskularne primjene te oko 2,5 - 4 sata nakon oralne primjene (otopine), iako su se te vrijednosti znatno mijenjale.
English: (~12.8µg/kg) 1 (~25.6µg/kg) 1 (~38.4µg/kg) 1 (~51.2µg/kg) 1 (~64µg/kg) 1 ml ml ml ml ml
Croatian: (~38,4 µg/kg) 1 (~51,2 µg/kg)
English: Sialanar should be taken by mouth.
Croatian: Put primjene Sialanar se uzima kroz usta.
English: • allergic reaction (rash, itching, red raised itchy rash (hives), difficulty breathing or swallowing, dizziness)
Croatian: • alergijska reakcija (osip, svrbež, crveni ispupčeni osip popraćen svrbežom (koprivnjača), otežano disanje ili gutanje, omaglica)
English: A reduction in anticholinergic and/or tricyclic antidepressants and MAOIs dosage may be necessary.
Croatian: Možda će biti potrebno smanjiti dozu antikolinergika i/ili tricikličkih antidepresiva i inhibitora monoaminooksidaze.
English: − has ulcerative colitis (inflammation of the intestine)
Croatian: − ima ulcerozni kolitis (upalu crijeva)
English: The significance of the non-clinical findings for humans is not clear, and the lack of human data on the medicinal product leads to glycopyrronium being contraindicated in pregnant women.There are insufficient data in the public domain to adequately assess effects on the reproductive system in young adults, and safety in human pregnancy has not been established.
Croatian: Značaj nekliničkih rezultata za ljude nije jasan, a zbog manjka podataka o lijeku koji se odnose na ljude glikopironij je kontraindiciran u trudnica.
English: One 250 ml bottle One 8 ml oral syringe One syringe adaptor.
Croatian: Jedna boca od 250 ml Jedna oralna štrcaljka od 8 ml Jedan nastavak za štrcaljku.
English: potassium chloride solid oral dose;
Croatian: kalijevim kloridom u krutom oralnom obliku;
English: Fear
Croatian: Strah
English: Raspberry flavouring (containing propylene glycol E1520) Sucralose (E955)
Croatian: Popis pomoćnih tvari natrijev benzoat (E211) aroma maline (sadrži propilenglikol E1520) sukraloza (E955) citratna kiselina (E330) pročišćena voda
English: Increased central nervous system effects have been reported in clinical trials including: irritability; drowsiness; restlessness; overactivity; short attention span; frustration; mood changes; temper outbursts or explosive behaviour; excessive sensitivity; seriousness or sadness; frequent crying episodes; fearfulness.
Croatian: U kliničkim ispitivanjima zabilježeni su pojačani učinci na središnji živčani sustav, uključujući: razdražljivost; omamljenost; nemir; prekomjernu aktivnost; kratkotrajnost pažnje; frustraciju;
English: • Constipation (difficulty in passing stool) - very common
Croatian: • Zatvor (otežano pražnjenje stolice) - vrlo često
English: Dryness of the skin
Croatian: Suha koža
English: • pneumonia
Croatian: • upale pluća
English: Amber coloured glass bottle with a high density polyethylene tamper evident child resistant closure with expanded low density polyethylene liner.
Croatian: Staklena boca boje jantara sa zatvaračem sigurnim za djecu s evidencijom otvaranja od polietilena visoke gustoće i zaštitnim pokrovom od ekspandiranog polietilena niske gustoće.
English: Renal impairment Severe renal impairment (see section 4.3).
Croatian: Teško oštećenje funkcije bubrega (vidjeti dio 4.3.).
English: Extrapolation of safety margins to the paediatric population is not possible, as no exposure data are available from repeated dose toxicology studies and no studies in juvenile animals have been performed with glycopyrronium.
Croatian: Budući da nisu dostupni podaci o izloženosti iz ispitivanja toksičnosti ponovljenih doza i da na mladim životinjama nisu provedena ispitivanja glikopironija, nije moguće ekstrapolirati margina sigurne primjene na pedijatrijsku populaciju.
English: Sialanar 320 micrograms /ml oral solution
Croatian: NAZIV LIJEKA Sialanar 320 mikrograma/ml oralna otopina
English: Corticosteroids: Steroid-induced glaucoma may develop with topical, inhaled, oral or intravenous, steroid administration.
Croatian: Kortikosteroidi: kod topikalne, inhalacijske, peroralne ili intravenske primjene steroida može doći do pojave glaukoma uzrokovanog steroidima.
English: Agitation
Croatian: Agitacija
English: Remove the oral syringe by holding the bottle and twisting the oral syringe gently.
Croatian: Držeći bocu i nježno zakrećući oralnu štrcaljku, izvadite oralnu štrcaljku iz boce.
English: Oral solution One 60 ml bottle One 8 ml oral syringe One syringe adaptor.
Croatian: Oralna otopina Jedna boca od 60 ml Jedna oralna štrcaljka od 8 ml Jedan nastavak za štrcaljku.
English: Dosing table for children and adolescents with mild to moderate renal impairment.
Croatian: Tablica 2. Tablica doziranja za djecu i adolescente s blagim do umjerenim oštećenjem funkcije bubrega.
English: Safety in breast-feeding has not been established.
Croatian: Nije utvrđena sigurnost primjene Sialanara tijekom dojenja.
English: Upper respiratory tract infection
Croatian: Infekcije i infestacije Infekcije gornjeg dišnog sustava
English: • Agitation
Croatian: • Uznemirenost
English: − has diarrhoea (frequent, loose watery stools)
Croatian: − ima proljev (učestale i meke, vodenaste stolice)
English: − stomach ache and swelling (paralytic ileus)
Croatian: − ima bolove i oticanje trbuha (paralitički ileus)
English: dose was low at approximately 3% (range 1.3-13.3%) in children aged 7-14 years undergoing intraocular surgery (n = 6) due to the medicinal product's low lipid solubility.
Croatian: Srednja apsolutna oralna bioraspoloživost glikopironija kod usporedbe jedne oralne doze od 50 µg/kg i jedne intravenske doze od 5 µg/kg bila je niska i iznosila je oko 3 % (raspon 1,3 - 13,3 %) u djece u dobi od 7 do 14 godina kod kojih je izvedena intraokularna operacija (n = 6) zbog niske topljivosti lijeka u lipidima.
English: Oesophageal candidiasis
Croatian: Ezofagealna kandidijaza
English: Younger children may be more susceptible to adverse events and this should be borne in mind when any dose adjustments are carried out.
Croatian: Kod provođenja svake prilagodbe doze valja imati na umu da mala djeca mogu biti podložnija nastanku nuspojava.
English: Sialanar 320 micrograms/ml oral solution Glycopyrronium
Croatian: Sialanar 320 µg/ml oralna otopina Glikopironij
English: • kidney problems or difficulty passing urine
Croatian: • probleme s bubrezima ili otežano mokrenje
English: Check the child's pulse if they seem unwell.
Croatian: Ako Vam se čini da djetetu nije dobro, provjerite djetetovo bilo.
English: Each ml of solution contains 400 micrograms glycopyrronium bromide equivalent to 320 micrograms glycopyrronium.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Jedan ml sadrži 400 mikrograma glikopironijeva bromida, što odgovara 320 mikrograma glikopironija.
English: dose; distribution half-life was 2.2 ± 1.3 minutes.
Croatian: U odraslih osoba zabilježena je brza distribucija glikopironija nakon jedne intravenske doze od 6 µg/kg; poluvijek distribucije iznosio je 2,2 ± 1,3 minute.
English: Glycopyrronium treatment should be withdrawn until the constipation resolves.
Croatian: Liječenje glikopironijem treba obustaviti dok ne nestane konstipacija.
English: • Upper respiratory tract infection (chest infection);
Croatian: • Infekcija gornjeg dišnog sustava;
English: Eye disorders
Croatian: Poremećaji oka Midrijaza
English: An association with upper GI bleeding and small bowel ulceration, stenosis, perforation, and obstruction has been observed.
Croatian: Uočena je povezanost s krvarenjem u gornjem dijelu probavnog sustava i ulceracijom, stenozom, puknućem i opstrukcijom tankog crijeva.
English: Sodium benzoate This medicinal product contains 2.3 mg sodium benzoate (E211) in each ml.
Croatian: Ovaj lijek sadrži 2,3 mg natrijeva benzoata (E211) u jednom ml.
English: • Urinary tract infection
Croatian: • Infekcija mokraćnog sustava
English: Glycopyrronium treatment should be withdrawn until the pneumonia resolves.
Croatian: Liječenje glikopironijem treba obustaviti dok ne nestane nuspojava upale pluća.
English: Insert the end of the oral syringe into the syringe adaptor and ensure it is secure.
Croatian: Umetnite kraj oralne štrcaljke u nastavak za štrcaljku i učvrstite.
English: • Nose bleeds (epistaxis)
Croatian: • Krvarenje iz nosa (epistaksa)
English: Sialanar is not recommended in children below the age of 3 years since there is very limited data on the efficacy and safety of glycopyrronium in this age group.
Croatian: Budući da su podaci o djelotvornosti i sigurnosti glikopironija za ovu dobnu skupinu vrlo ograničeni, ne preporučuje se primjena Sianalara u djece mlađe od 3 godine.
English: Respiratory, thoracic and mediastinal disorders
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja Kongestija nosa
English: The active substance is glycopyrronium.
Croatian: Djelatna tvar je glikopironij.
English: • constipation
Croatian: • konstipacije
English: • Pneumonia (sever chest infection) - common
Croatian: • Upala pluća (teška infekcija prsišta) - često
English: Hepatic impairment
Croatian: Psihijatrijski poremećaji Razdražljivost
English: What you need to know before you give Sialanar Do not give Sialanar if the child or adolescent:
Croatian: Nemojte davati Sialanar ako dijete ili adolescent:
English: Sialanar Oral Solution
Croatian: Sialanar Oralna otopina
English: Ask your doctor if you need further advice.
Croatian: Ako trebate dodatni savjet, obratite se svom liječniku.
English: Other
Croatian: Ostalo
English: 6.6 Special precautions for disposal and other handling
Croatian: Posebne mjere za zbrinjavanje i druga rukovanja lijekom Upute za uporabu
English: Nervous system disorders
Croatian: Poremećaji živčanog sustava Glavobolja
English: Thane Road
Croatian: Marine House
English: Renal and urinary disorders
Croatian: Poremećaji bubrega i mokraćnog sustava Retencija urina
English: Turn the bottle upright.
Croatian: Postavite bocu u uspravni položaj.
English: Caution should be exercised in children with compromised blood brain barrier eg.
Croatian: Potreban je oprez u djece s oštećenom krvno-moždanom barijerom, kao što su djeca s intraventrikularnim shuntom, tumorom mozga ili encefalitisom.
English: If your child gets any side effects, talk to your doctor or pharmacist.
Croatian: Ako u djeteta primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
English: administration probably reflects the complex absorption and distribution of glycopyrronium by each route.
Croatian: Činjenica da su potonja dva poluvijeka, posebice onaj kod oralne primjene, dulji nego kod intravenske primjene vjerojatno odražava složenu apsorpciju i distribuciju glikopironija svakim od tih dvaju putova.
English: • Fungal infection (thrush) of the throat (oesophageal candidiasis)
Croatian: • Gljivična infekcija jednjaka (ezofagealna kandidijaza)
English: Nausea
Croatian: Nemir
English: Oral use.
Croatian: Korištenje oralne štrcaljke
English: Talk to your doctor or pharmacist for further information about medicines to avoid whilst taking Sialanar.
Croatian: Za dodatne informacije o tome koje lijekove izbjegavati dok uzimate Sialanar obratite se liječniku ili ljekarniku.
English: A reduction in corpora lutea was observed in female rats administered glycopyrronium.
Croatian: U ženki štakora kojima je dan glikopironij uočeno je smanjenje žutog tijela.
English: fearfulness
Croatian: Konstipacija
English: Manufacturer
Croatian: PROMET
English: Drowsiness
Croatian: Omamljenost
English: • Difficulty in passing stools (constipation)
Croatian: • Otežano pražnjenje stolice (zatvor)
English: Angle-closure glaucoma
Croatian: Glaukom zatvorenog kuta
English: It is important to make sure an acurate dose is given each time, in order to prevent harmful effects of Sialanar seen with dosing errors or overdose.
Croatian: U svrhu sprječavanja nastanka nuspojava lijeka Sialanar uočenih kod pogrešaka u doziranju ili predoziranja, važno je da svaki put date točnu dozu.
English: • Information on the administration of Sialanar
Croatian: • informacije o primjeni lijeka Sialanar
English: • Nasal congestion
Croatian: • Navala crvenila
English: • Flushing
Croatian: • mučnina
English: The majority of these side effects disappear within 1 to 2 days.
Croatian: Većina ovih nuspojava nestaje za 1 do 2 dana.
English: Further information can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/foclivia.
Croatian: Više informacija dostupno je na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/foclivia.
English: This helps to protect against the disease caused by the virus.
Croatian: To pomaže u zaštiti od bolesti koju uzrokuje virus.
English: It contains a flu strain called A/Vietnam/1194/2004 (H5N1).
Croatian: Sadrži soj gripe zvan A/Vietnam/1194/2004 (H5N1).
English: The authorisation was based on the authorisation granted to Focetria in 2007 (‘informed consent').
Croatian: Odobrenje se temeljilo na odobrenju izdanom za cjepivo Focetria 2007. godine („informirani pristanak”).
English: This overview was last updated in 09-2019.
Croatian: Pregled informacija posljednji je put ažuriran 9. 2019.
English: Foclivia has been authorised under ‘exceptional circumstances'.
Croatian: Cjepivo Foclivia odobreno je u „iznimnim okolnostima”.
English: The vaccine also contains an ‘adjuvant' to increase the vaccine's effectiveness.
Croatian: Cjepivo sadrži i „adjuvans” za poboljšanje učinkovitosti cjepiva.
English: This is a special type of vaccine that can be developed to help with the management of a future pandemic.
Croatian: To je posebna vrsta cjepiva koje se može razviti kako bi se bolje kontrolirale buduće pandemije.
English: However, if a pandemic has started, it may be appropriate to give the vaccine to these people, as long as facilities for resuscitation are available.
Croatian: Međutim, ako je pandemija započela, bilo bi preporučljivo dati cjepivo tim bolesnicima, pod uvjetom da su dostupne prostorije za oživljavanje.
English: When the person comes into contact with this or a similar virus, these antibodies, together with other components of the immune system, will be able to kill the viruses and help protect against the disease.
Croatian: Kada je osoba izložena ovom ili sličnom virusu, ta će protutijela zajedno s drugim dijelovima imunosnog sustava moći uništiti viruse i pomoći u zaštiti protiv bolesti.
English: They test this vaccine to see how people react to it, allowing them to predict how people will react when the flu strain causing a pandemic is included in the vaccine.
Croatian: One testiraju ovo cjepivo da vide kako će ljudi reagirati na njega, što im pomaže da predvide kako će osobe reagirati kad se soj virusa gripe koji uzrokuje pandemiju uvrsti u cjepivo.
English: What measures are being taken to ensure the safe and effective use of Foclivia?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena cjepiva Foclivia?
English: According to EMA's criteria, a pandemic preparedness vaccine needs to bring about protective levels of antibodies in at least 70% of people for it to be considered suitable.
Croatian: U skladu s kriterijima EMA-e, cjepivo spremno protiv pandemije treba potaknuti razvoj zaštitnih razina protutijela kod najmanje 70 % osoba da bi se moglo smatrati prikladnim.
English: What is Foclivia and what is it used for?
Croatian: Što je Foclivia i za što se koristi?
English: The main measures of effectiveness were the levels of antibodies against the flu virus in the blood before vaccination, on the day of the second injection (day 22), and 21 days later (day 43).
Croatian: Glavne mjere djelotvornosti bile su razine protutijela na virus gripe u krvi bolesnika prije cijepljenja, na dan druge injekcije (22. dan) te 21 dan nakon toga (43. dan).
English: Foclivia would be given according to official recommendations.
Croatian: Foclivia se daje u skladu sa službenim preporukama.
English: Vaccines work by preparing the immune system (the body's natural defences) to defend itself against a disease.
Croatian: Cjepiva djeluju tako što pripremaju imunosni sustav (prirodnu obranu tijela) na obranu od određene bolesti.
English: This means that, because the vaccine is a pandemic preparedness vaccine and does not yet contain the strain of flu virus that is causing a pandemic, it has not been possible to obtain full information about the final pandemic vaccine.
Croatian: To znači da, zbog toga što je cjepivo spremno protiv pandemije i još uvijek ne sadrži soj virusa gripe koji uzrokuje pandemiju, nije bilo moguće dobiti cjelovite informacije o konačnom cjepivu za pandemijsku gripu.
English: The vaccine can only be obtained with a prescription and should be used according to official recommendations.
Croatian: Cjepivo se izdaje samo na recept te se treba primjenjivati u skladu sa službenim preporukama.
English: Before a pandemic starts, nobody knows which strain of flu virus will be involved, so companies cannot prepare the correct vaccine in advance.
Croatian: Prije početka pandemije nitko ne zna o kojem se soju gripe radi pa tvrtke ne mogu unaprijed pripremiti ispravno cjepivo.
English: The figure was 85% in people who received the 15-microgram dose.
Croatian: Brojka je iznosila 85 % u bolesnika koji su primali dozu od 15 mikrograma.
English: The main study of Foclivia included 486 healthy people (a third of whom were over the age of 60) and compared the ability of two doses of Foclivia to trigger the production of antibodies (immunogenicity).
Croatian: Glavno ispitivanje na lijeku Foclivia uključivalo je 486 zdravih ispitanika (od kojih je trećina bila starija od 60 godina), a u njemu je uspoređena sposobnost dviju doza da potaknu nastanak protutijela (imunogenost).
English: Foclivia is a vaccine used in adults to protect against flu when a ‘pandemic' has been officially declared by the World Health Organization (WHO) or the European Union (EU).
Croatian: Foclivia je cjepivo za odrasle osobe koje se koristi kao zaštita protiv gripe kada Svjetska zdravstvena organizacija (SZO) ili Europska unija (EU) službeno proglase „pandemiju”.
English: Twenty-one days after the second injection, 86% of the people receiving the vaccine with 7.5 micrograms haemagglutinin had levels of antibodies that would protect them against H5N1.
Croatian: Dvadeset i jedan dan nakon druge injekcije 86 % osoba koje su primile cjepivo sa 7,5 mikrograma hemaglutinina imalo je razine protutijela koje bi ih zaštitile od H5N1.
English: The study showed that Foclivia produced an antibody response that satisfies these criteria.
Croatian: Ispitivanje je pokazalo da je cjepivo Foclivia proizvelo odgovor protutijelima koji zadovoljava te kriterije.
English: Instead, they can prepare a vaccine that contains a strain of flu virus specifically chosen because nobody has been exposed to it, and to which nobody is immune.
Croatian: Umjesto toga, tvrtke mogu pripremiti cjepivo koje sadrži soj virusa gripe koji je posebno odabran jer nitko nije bio izložen tom soju i na njega nitko nije imun.
English: Other information about Foclivia
Croatian: Ostale informacije o cjepivu Foclivia
English: When a person is given the vaccine, the immune system recognises the virus as ‘foreign' and makes antibodies against it.
Croatian: Kada osoba primi cjepivo, imunosni sustav prepoznaje virus kao „strano tijelo” i proizvodi protutijela na njega.