FrancophonIA/ELRC3.0 huggingface dataset:
English: Do not use this medicine after the expiry date which is stated on the carton and blisters after EXP.
Croatian: Ovaj lijek ne smije se upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisterima iza oznake „Rok valjanosti“ ili EXP.
English: It is used to relieve menopausal symptoms in the vagina such as dryness or irritation.
Croatian: Koristi se za ublažavanje menopauzalnih simptoma u rodnici, kao što su suhoća i nadraženost.
English: Cases of hypertension have been reported in clinical trials with an uncommon frequency and similar incidence rates were observed in both groups (6.5 mg prasterone and placebo).
Croatian: U kliničkim ispitivanjima zabilježeni su manje česti slučajevi hipertenzije, a u obje skupine primijećene su slične stope incidencije (6,5 mg prasterona i placebo).
English: • you have any blood clotting problem that needs long-term treatment with a medicine used to prevent blood clots;
Croatian: • ako imate problema sa zgrušavanjem krvi koji zahtijevaju dugotrajno liječenje lijekom koji sprječava stvaranje krvnih ugrušaka,
English: • a disease affecting the eardrum and hearing (otosclerosis);
Croatian: • bolest koja utječe na bubnjiće uha i sluh (otoskleroza),
English: • Oestrogens increase thyroid binding globulin (TBG), leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels (by radio-immunoassay).
Croatian: • Estrogeni povećavaju globulin koji veže tiroksin (TBG), što dovodi do povišenih ukupnih cirkulirajućih hormona štitnjače, što se mjeri jodom vezanim na proteine (PBI), razinom T4 (mjereno metodom kolone ili radioimunotestom) ili razinom T3 (mjereno radioimunotestom).
English: There is some evidence of increased risk of probable dementia in women who start using continuous combined or oestrogen-only HRT after the age of 65.
Croatian: Postoje određeni dokazi o povećanom riziku od vjerojatne demencije u žena koje počnu primjenjivati stalno kombinirano ili samo estrogensko HNL nakon 65. godine.
English: After 12 weeks of daily treatment with a prasterone 6.5 mg pessary (n=81 in Trial 1 and n=325 in Trial 2), the change from baseline, in comparison with placebo treatment (n=77 in Trial 1 and n=157 in Trial 2), demonstrated significant improvements of the 3 co-primary endpoints compared to placebo in both studies, namely increase of the percentage of superficial cells (p<0.0001), decrease of the percentage of parabasal cells (p<0.0001), and decrease in the vaginal pH (p<0.0001).
Croatian: Nakon 12 tjedana svakodnevne primjene vagitorija od 6,5 mg prasterona (n=81 u 1. ispitivanju i n=325 u 2. ispitivanju), zabilježeno je značajno poboljšanje u odnosu na početno stanje u usporedbi sa skupinom koja je primala placebo (n=77 u 1. ispitivanju i n=157 u 2. ispitivanju) u oba ispitivanja za 3 ko-primarne mjere ishoda, odnosno došlo je do povećanja postotka superficijalnih stanica (p<0,0001), smanjenja postotka parabazalnih stanica (p<0,0001) te smanjenja vaginalne pH vrijednosti (p<0,0001).
English: Go for regular breast screening, as recommended by your doctor.
Croatian: Redovito pregledavajte dojke, kao što će Vas uputiti liječnik.
English: Blood clots in a vein (thrombosis)
Croatian: Krvni ugrušci u veni (tromboza)
English: Cases of breast and ovarian cancer have been reported in women treated with 6.5 mg of prasterone for 52 weeks (see section 4.4).
Croatian: Zabilježeni su slučajevi raka dojke i jajnika u žena koje su primale 6,5 mg prasterona tijekom 52 tjedna (vidjeti dio 4.4).
English: Prasterone administered in the vagina is an inactive precursor that enters the vaginal cells and is converted intracellularly into cell-specific small amounts of both oestrogens and androgens depending upon the level of enzymes expressed in each cell type.
Croatian: Apsorpcija Prasteron koji se primjenjuje u rodnici neaktivni je perkusor koji ulazi u vaginalne stanice i unutar stanice se pretvara u male količine estrogena i androgena specifične za stanicu, ovisno o razini enzima koji se eksprimira u svakoj vrsti stanice.
English: For the treatment of postmenopausal symptoms, Intrarosa should only be initiated for symptoms that adversely affect quality of life.
Croatian: Lijek Intrarosa za liječenje postmenopauzalnih simptoma treba primjenjivati samo ako se radi o simptomima koji nepovoljno utječu na kvalitetu života.
English: • Any increased risk in users of oestrogen-only therapy is substantially lower than that seen in users of oestrogen-progestagen combinations.
Croatian: • Svaki povećani rizik u žena koje su primale samo estrogensku terapiju znatno je niži od onoga primijećenog u žena koje su primale kombiniranu estrogensku-progestagensku terapiju.
English: Table 1 shows the mean change in severity score in MBS dyspareunia after 12 weeks with associated statistical testing for the difference vs. placebo for Trial 1 (ERC-231) and Trial 2 (ERC-238).
Croatian: dispareuniju nakon 12 tjedana, uz povezani statistički test razlike u odnosu na placebo u 1. ispitivanju (ERC-231) i 2. ispitivanju (ERC-238).
English: The most bothersome symptom (MBS) dyspareunia (co-primary endpoint) was assessed at baseline and 12 weeks with the severity scored as follows: None=0, Mild=1, Moderate=2, Severe=3.
Croatian: Simptomi (subjektivne mjere) Najgori simptom (MBS), dispareunija, (ko-primarna mjera ishoda) procijenjena je na početku ispitivanja i nakon 12 tjedana, pri čemu je težina ocijenjena na sljedeći način: Ništa=0, Blaga=1, Umjerena=2, Teška=3.
English: The experience in treating women with a premature menopause (due to ovarian failure or surgery) is limited.
Croatian: Iskustvo u liječenju žena s prijevremenom menopauzom (zbog zatajenja ili operacije jajnika) je ograničeno.
English: Risk ratio & 95%CI#
Croatian: Omjer rizika i 95 % CI#
English: Intrarosa is a white to off-white, bullet-shaped pessary approximately 28 mm long and 9 mm in diameter at its widest end.
Croatian: Intrarosa je bijeli do gotovo bijeli vagitorij oblika metka približne duljine 28 mm i promjera 9 mm na najširem kraju.
English: Intrarosa is for use in postmenopausal women only.
Croatian: Intrarosa je namijenjena samo za žene u postmenopauzi.
English: Prasterone corrects the symptoms and signs of vulvar and vaginal atrophy by replacing the oestrogens which are normally produced before menopause by the ovaries of women.
Croatian: Prasteron ublažava simptome i znakove vulvarne i vaginalne atrofije nadomještanjem estrogena koje prije menopauze normalno proizvode jajnici.
English: Pessary 28 pessaries and 6 applicators.
Croatian: Vagitoriji 28 vagitorija i 6 aplikatora.
English: Figure 1: Serum Concentrations of Prasterone (A), Testosterone (B), and Estradiol (C) Measured Over a 24h Period on Day 7 Following Daily Administration of Placebo or Intrarosa (mean ± S.D.)
Croatian: Slika 1.: Koncentracije prasterona (A), testosterona (B) i estradiola (C) u serumu mjereno tijekom razdoblja od 24 sata na 7. dan nakon svakodnevne primjene placeba ili lijeka Intrarosa (srednja vrijednost ± SD)
English: • HRT will not prevent memory loss.
Croatian: • Hormonsko nadomjesno liječenje ne sprječava gubitak pamćenja.
English: For women aged 50 to 54 years taking 5 years of HRT, this results in about 1 extra case per 2000 users.
Croatian: Kod žena u dobi od 50 do 54 godine koje su 5 godina primale HNL, to daje otprilike 1 dodatni slučaj na 2000 korisnica.
English: • yellowing of your skin or the whites of your eyes (jaundice).
Croatian: • žutu boju kože ili bjeloočnica (žutica).
English: Risk ratio and 95%CI
Croatian: Omjer rizika i 95 % CI
English: The applicator should be activated (by pulling back the plunger) before use.
Croatian: Ako se umeće pomoću aplikatora, treba učiniti sljedeće: Treba aktivirati aplikator (povlačenjem klipa) prije upotrebe.
English: How much to use Use one pessary once a day, at bedtime.
Croatian: Koliko primjenjivati Primijenite jedan vagitorij jednom dnevno, prije spavanja.
English: Pregnancy Intrarosa is not indicated in pre-menopausal women of child-bearing age, including pregnancy.
Croatian: Lijek Intrarosa nije indiciran u žena reproduktivne dobi prije menopauze, uključujući trudnice.
English: The risk ratio is not constant but will increase with increasing duration on use Note: Since the background incidence of breast cancer differs by EU country, the number of additional cases of breast cancer will also change proportionately.
Croatian: Napomena: Budući da se osnovna incidencija raka dojke razlikuje među zemljama EU-a, broj dodatnih slučajeva raka dojke također će se proporcionalno mijenjati.
English: Additional cases per 1000 HRT users over 5 years (95%CI)
Croatian: Dodatni slučajevi na 1000 žena koje su primale HNL tijekom 5 godina (95 % CI)
English: • Leave your index (pointer) finger free to press the applicator plunger after the applicator is inserted into your vagina.
Croatian: • Neka vam kažiprst bude slobodan kako biste mogli pritisnuti klip aplikatora nakon što ga umetnete u rodnicu.
English: Prasterone is metabolised into estrogenic compounds.
Croatian: Prasteron se metabolizira u estrogene spojeve.
English: Intrarosa can be inserted in the vagina with the finger or with an applicator provided within the identified pack.
Croatian: Lijek Intrarosa može se umetnuti u rodnicu prstom ili pomoću aplikatora koji se isporučuje u pakiranju.
English: The following side effects have been reported with HRT containing estrogens but not with Intrarosa during clinical trials:
Croatian: Sljedeće nuspojave zabilježene su tijekom primjene hormonskog nadomjesnog liječenja koje sadrži estrogene, ali nisu prijavljene pri primjeni lijeka Intrarosa tijekom kliničkih ispitivanja:
English: - The active substance is prasterone.
Croatian: - Djelatna tvar je prasteron.
English: The risk of haemorrhagic stroke is not increased during use of HRT.
Croatian: Rizik od hemoragijskog moždanog udara ne povećava se tijekom primjene HNL-a.
English: − with a uncommon frequency (may affect up to 1 in 100 people): benign cervical or uterine polyps, benign breast mass.
Croatian: - manje često (može se javiti u do 1 na 100 osoba): dobroćudni cervikalni ili maternični polipi, dobroćudna kvržica na dojci.
English: • The risk of coronary artery disease is slightly increased in users of combined oestrogen-progestagen HRT over the age of 60 (see section 4.4).
Croatian: • Rizik od bolesti koronarnih arterija blago je povećan u žena koje primaju HNL koje sadrži kombinaciju estrogena i progestagena u dobi iznad 60 godina (vidjeti dio 4.4).
English: Additional cases per 1000 HRT users
Croatian: Dodatni slučajevi na 1000
English: If you notice any of the following when taking HRT:
Croatian: Ako primijetite bilo što od sljedećeg pri primjeni hormonskog nadomjesnog liječenja:
English: • growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia);
Croatian: • rast tkiva sluznice maternice izvan maternice (endometrioza) ili povijest prekomjernog rasta sluznice maternice (hiperplazija endometrija),
English: Table 3: Cmax and AUC0-24 of Prasterone, Testosterone, and Estradiol on Day 7 Following Daily Administration of Placebo or Intrarosa (mean ± S.D.)
Croatian: Tablica 3.: Cmax i AUC0-24 za prasteron, testosteron i estradiol 7. dana nakon svakodnevne primjene placeba ili lijeka Intrarosa (srednja vrijednosti ± SD)
English: Abnormal Pap smear (mostly ASCUS or LGSIL)
Croatian: (većinom ASCUS ili LGSIL)
English: • blood clots in the veins of the legs or lungs (venous thromboembolism);
Croatian: • krvni ugrušci u venama nogu ili pluća (venska tromboembolija),
English: Intrarosa has no influence in the ability to drive and use machines.
Croatian: Intrarosa ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: • Slowly pull the plastic tabs on the pessary away from each other while keeping the pessary still between your fingers.
Croatian: • Polako razdvojite plastične jezičce omota na vagitoriju tako da vagitorij držite među prstima.
English: Posology The recommended dose is 6.5 mg prasterone (one pessary) administered once daily, at bedtime.
Croatian: Preporučena doza je 6,5 mg prasterona (jedan vagitorij) jednom dnevno, prije spavanja.
English: • Previous or current venous thromboembolism (deep vein thrombosis, pulmonary embolism);
Croatian: • Prijašnja ili postojeća venska tromboembolija (tromboza dubokih vena, plućna embolija);
English: A. Using the applicator
Croatian: Upotreba aplikatora
English: No data on efficacy and safety are available in women currently treated with hormonal therapy such as: androgens, hormone replacement therapy (oestrogen alone or combined with progestogens).
Croatian: Ne postoje podaci o djelotvornosti i sigurnosti za žene koje trenutačno primaju hormonsku terapiju kao što su: androgeni, hormonsko nadomjesno liječenje (samo estrogen ili estrogen u kombinaciji s progestagenima).
English: In women with an intact uterus, the risk of endometrial hyperplasia and carcinoma is increased when exogenous oestrogens are administered for prolonged periods.
Croatian: U žena s netaknutom maternicom povećava se rizik od hiperplazije i karcinoma endometrija pri dugotrajnoj primjeni egzogenih estrogena.
English: Intrarosa is used to treat postmenopausal women having moderate to severe symptoms of vulvar and vaginal atrophy.
Croatian: Intrarosa se koristi za liječenje žena u postmenopauzi koje imaju umjerene do teške simptome vulvarne i vaginalne atrofije.
English: • Tear off one wrapped pessary from the 7-pessary strip.
Croatian: • Odvojite jedan zamotani vagitorij iz trake sa 7 vagitorija.
English: • changes in the nipple;
Croatian: • promjene na bradavicama,
English: − Wipe with a paper towel and reassemble.
Croatian: Obrišite papirnatim ručnikom i ponovno sastavite.
English: There is some evidence of a higher risk of memory loss in women who start using HRT after the age of 65.
Croatian: Postoje određeni dokazi o povećanom riziku od gubitka pamćenja u žena koje počnu primjenjivati hormonsko nadomjesno liječenje nakon 65. godine.
English: The overall evidence suggests an increased risk of breast cancer in women taking combined oestrogenprogestagen and possibly also oestrogen-only systemic HRT, that is dependent on the duration of taking HRT.
Croatian: Sveukupni dokazi ukazuju na povećani rizik od raka dojke u žena koje uzimaju sistemsko hormonsko nadomjesno liječenje (HNL) koje sadrži kombinaciju estrogena i progestagena, i moguće kod onih koje uzimaju sistemsko HNL koje sadrži samo estrogen, što ovisi o trajanju uzimanja HNL-a.
English: At baseline, women had ≤ 5.0% superficial cells in the vaginal smear, a vaginal pH ˃ 5.0 and they had identified dyspareunia (moderate to severe) as their most bothersome symptom (MBS) of VVA.
Croatian: Na početku ispitivanja žene su imale ≤ 5,0 % superficijalnih stanica u vaginalnom razmazu, vaginalnu pH vrijednost ˃ 5,0, kao i dispareuniju (umjerenu do tešku) kao najgori simptom (engl. most bothersome symptom, MBS) vulvarne i vaginalne atrofije.
English: Intrarosa has not been studied in women with endometrial hyperplasia.
Croatian: Lijek Intrarosa nije ispitivan u žena s hiperplazijom endometrija.
English: However Intrarosa is for local treatment in the vagina and the absorption into the blood is very low.
Croatian: Međutim, lijek Intrarosa je namijenjen je za lokalnu primjenu u rodnici, pri čemu je apsorpcija u krv vrlo niska.
English: The occurrence of such an event is more likely in the first year of using HT (see section 4.4).
Croatian: Pojava takvog događaja vjerojatnija je u prvoj godini primjene hormonske terapije (vidjeti dio 4.4).
English: Concomitant use with systemic hormone replacement therapy (oestrogen-only or oestrogenprogestagen combination or androgen treatment) or vaginal oestrogens has not been investigated and is therefore not recommended.
Croatian: Istodobna primjena sa sistemskim hormonskim nadomjesnim liječenjem (samo estrogensko ili kombinirano estrogensko-progestagensko ili androgensko liječenje) ili vaginalnim estrogenima nije ispitana te se stoga ne preporučuje.
English: Pregnancy, breast feeding and fertility
Croatian: Trudnoća, dojenje i plodnost Trudnoća i dojenje
English: The risk of getting stroke is about 1.5 times higher in HRT users than in non-users.
Croatian: Rizik od moždanog udara otprilike je 1,5 puta veći u žena koje koriste HNL nego u onih koje ne koriste terapiju.
English: There is no consensus about the possible role of varicose veins in VTE.
Croatian: Ne postoji konsenzus o mogućoj ulozi varikoznih vena u venskoj tromboemboliji.
English: • If VTE develops after initiating therapy, the drug should be discontinued.
Croatian: • Ako se nakon uvođenja liječenja razvije venska tromboembolija, treba prekinuti liječenje.
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati lijek Intrarosa Lijek čuvajte izvan pogleda i dohvata djece.
English: Systemic oestrogen-only therapy is associated with an up to 1.5-fold increase in risk of ischaemic stroke.
Croatian: Sistemsko liječenje samo estrogenima povezuje se s do 1,5 puta većim rizikom od ishemijskog moždanog udara.
English: Stop taking Intrarosa and see a doctor immediately
Croatian: Prekid primjene lijeka Intrarosa i hitan posjet liječniku
English: There is no relevant use of Intrarosa in female children of any age group for the indication of vulvar and vaginal atrophy due to menopause.
Croatian: Pedijatrijska populacija Nema relevantne primjene lijeka Intrarosa u ženske djece bilo koje dobne skupine za indikaciju vulvarne i vaginalne atrofije prouzročene menopauzom.
English: Use of oestrogen-only or combined oestrogen-progestagen HRT has been associated with a slightly increased risk of having ovarian cancer diagnosed (see section 4.4).
Croatian: Primjena HNL-a koji sadrže samo estrogene ili kombinaciju estrogena i progestagena povezana je s blago povećanim rizikom od dijagnoze raka jajnika (vidjeti dio 4.4).
English: • you have systemic lupus erythematosus (SLE);
Croatian: • ako imate sistemski eritemski lupus (SLE), • ako imate rak.
English: • Systemic HRT is associated with a 1.3-3 fold risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism.
Croatian: • Sistemsko hormonsko nadomjesno liječenje (HNL) povezano je s 1,3 do 3 puta većim rizikom od razvoja venske tromboembolije (VTE), tj. duboke venske tromboze ili plućne embolije.
English: It is available in blister packs of 28 pessaries with 6 applicators.
Croatian: Lijek je dostupan u blister pakiranjima koja sadrže 28 vagitorija i 6 aplikatora.
English: 2 *WHI study in women with no uterus, which did not show an increase in risk of breast cancer 3 *Study in women with no uterus
Croatian: 1 *Izračunato prema osnovnim vrijednostima stopa incidencije u razvijenim zemljama 2 *WHI ispitivanje u žena bez maternice u kojih nije zabilježeno povećanje rizika od raka dojke
English: An oestrogen-mediated increase in the number of superficial and intermediate cells and decrease in the number of parabasal cells in the vaginal mucosa is noted.
Croatian: Primijećeno je povećanje broja superficijalnih i intermedijarnih stanica te smanjenje broja parabazalnih stanica u vaginalnoj sluznici uzrokovano estrogenom.
English: The following risks have been associated with systemic HRT and apply to a lesser extent for oestrogen products for vaginal application of which the systemic exposure to the oestrogen remains within the normal postmenopausal range.
Croatian: Sljedeći rizici povezuju se sa sistemskim hormonskim nadomjesnim liječenjem te se u manjoj mjeri odnose na estrogenske lijekove za vaginalnu primjenu kod kojih sustavna izloženost estrogenu ostaje u normalnom rasponu za postmenopauzu.
English: Intrarosa is indicated for the treatment of vulvar and vaginal atrophy in postmenopausal women having moderate to severe symptoms.
Croatian: Lijek Intrarosa indiciran je za liječenje vulvarne i vaginalne atrofije u žena u postmenopauzi s umjerenim do teškim simptomima.
English: US WHI studies - additional risk of breast cancer after 5 years' use
Croatian: Američka WHI ispitivanja - dodatni rizik od raka dojke nakon 5 godina liječenja
English: Uncommon (≥ 1/1,000 to < 1/100)
Croatian: (≥ 1/1000 i <1/100)
English: Trial 1 Trial 2
Croatian: Ispitivanje 1. Ispitivanje 2.
English: If you become pregnant, stop taking Intrarosa and contact your doctor.
Croatian: Ako zatrudnite, prestanite primjenjivati lijek
English: You are now ready to insert the pessary into your vagina.
Croatian: Sada možete umetnuti vagitorij u rodnicu.
English: • The use of oestrogen-only and oestrogen + progestagen therapy is associated with an up to 1.5 fold increased relative risk of ischaemic stroke.
Croatian: • Upotreba terapije koja sadrži samo estrogen i terapije koja sadrži kombinaciju estrogena i progestagena povezana je s do 1,5 puta većim relativnim rizikom od ishemijskog moždanog udara.
English: Intrarosa contains the active substance prasterone.
Croatian: Intrarosa sadrži djelatnu tvar prasteron.
English: This may relieve discomfort in the vagina.
Croatian: To može ublažiti simptome nelagode u rodnici.
English: One Case of ovarian cancer has been reported on 1196 women who have been exposed with the 6.5 mg dose which is above the incidence rate observed in the normal population of the same age.
Croatian: Prijavljen je jedan slučaj raka jajnika na uzorku od 1196 žena u kojih je primjenjivana doza od 6,5 mg, što je iznad stope incidencije zabilježene u populaciji zdravih žena iste dobi.
English: One case of breast cancer at week 52 has been reported on 1196 women who have been exposed with the 6.5 mg dose which is below the incidence rate observed in the normal population of the same age.
Croatian: Zabilježen je jedan slučaj raka dojke u 52. tjednu na uzorku od 1196 žena u kojih je primjenjivana doza od 6,5 mg, što je ispod stope incidencije zabilježene u populaciji zdravih žena iste dobi.
English: • If you have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency);
Croatian: • Ustanovljeni trombofilni poremećaji (npr. nedostatak proteina C, proteina S ili antitrombina,
English: • probable memory loss if HRT is started over the age of 65.
Croatian: • vjerojatan gubitak pamćenja ako se hormonsko nadomjesno liječenje uvede nakon 65. godine.
English: Million Women study- Estimated additional risk of breast cancer after 5 years' use
Croatian: Ispitivanje na milijun žena (MWS) - procijenjeni dodatni rizik od raka dojke nakon 5 godina liječenja
English: WHI studies combined - Additional risk of ischaemic stroke*4 over 5 years' use
Croatian: Kombinirana WHI ispitivanja - dodatni rizik od ishemijskog moždanog udara*4 tijekom 5 godina terapije
English: Coronary artery disease (CAD)/ Hypertension
Croatian: Bolest koronarnih arterija / hipertenzija
English: It could be a sign that your endometrium has become thicker.
Croatian: To može biti znak da je došlo do zadebljanja sluznice maternice.
English: For more information, see ‘Blood clots in a vein (thrombosis)'
Croatian: Više informacija potražite u dijelu „Krvni ugrušci u veni (tromboza)“
English: If a thrombophilic defect is identified which segregates with thrombosis in family members or if the defect is ‘severe' (e.g, antithrombin, protein S, or protein C deficiencies or a combination of defects) HRT is contraindicated.
Croatian: Ako se otkrije trombofilni poremećaj koji se povezuje s trombozom u članova obitelji ili je poremećaj „težak“ (npr. nedostatak antitrombina, proteina
English: How Intrarosa works
Croatian: Kako Intrarosa djeluje
English: The applicator should be inserted into the vagina as far as it can comfortably go without force.
Croatian: Aplikator treba umetnuti u rodnicu što dublje bez primjene sile.
English: These risks apply less to vaginally administered oestrogen treatments:
Croatian: Ti se rizici manje odnose na estrogensku terapiju koja se primjenjuje u rodnicu:
English: Taking oestrogen-only HRT tablets for a long time can increase the risk of developing cancer of the womb lining (the endometrium).
Croatian: Dugotrajno uzimanje tableta za hormonsko nadomjesno liječenje koje sadrže samo estrogen može povećati rizik od nastanka raka sluznice maternice (endometrija).