FrancophonIA/ELRC3.0 huggingface dataset:
English: 25 mg/ml Glucose Monohydrate; 5,67 mg/ml Sodium Chloride; 0,257 mg/ml Calcium Chloride Dihydrate; 0,152 mg/ml Magnesium Chloride Hexahydrate; 3,92 mg/ml Sodium Lactate
Estonian: 25 mg/ml Glükoosmonohüdraat; 5,67 mg/ml Naatriumkloriid; 0,257 mg/ml Kaltsiumkloriiddihüdraat; 0,152 mg/ml
English: Annex I
Estonian: Ühendkuningri ik
English: 25 mg/ml Glucose Monohydrate; 5,38 mg/ml Sodium Chloride; 0,184 mg/ml Calcium Chloride Dihydrate; 0,051 mg/ml Magnesium Chloride Hexahydrate; 4,48 mg/ml Sodium Lactate
Estonian: 25 mg/ml Glükoosmonohüdraat; 5,38 mg/ml Naatriumkloriid; 0,184 mg/ml Kaltsiumkloriiddihüdraat; 0,051 mg/ml
English: Dianeal PD4 med glucos 38,6 mg/ml
Estonian: Dianeal PD4 Glucose 38,6 mg/ml
English: 0.051 g, Sodium-lactate Ph.Eur.
Estonian: 0.051 g, Naatrium(S)laktaat Ph.Eur.
English: solution for haemodialysis, haemodiafiltration and haemofiltration hemodialysis
Estonian: Hemodialüüsi,hemodiafiltratsioonija hemofiltratsioonilahus
English: 1.1 g / l 6.43 g / l 0.257 g / l 0.152 g / l 3.36 g / l solution for haemodialysis hemodialysis
Estonian: 1.1 g / l 6.43 g / l 0.257 g / l 0.152 g / l 3.36 g / l
English: 1,36 % w/v / 13,6 mg/ml peritoneal use
Estonian: 1,36% w/v/ 13,6 mg/ml
English: Nutrineal PD4 mit 1,1 % Aminosäuren
Estonian: Nutrineal PD4 mit 1,1 % Aminosauren
English: magnesium chloride 0.015%w/v; potassium chloride 0.029%w/v; calcium chloride 0.026%w/v; sodium lactate 0.336%w/v; sodium chloride 0.643%w/v; glucose 0.110%w/v solution for haemodialysis/hae mofiltration intraarterial use, intravenous use
Estonian: 0.026%w/v; naatriumlaktaat 0.336%w/v; naatriumkloriid 0.643%w/v; glükoos 0.110%w/v
English: sodium chloride 0.643%w/v; magnesium chloride 0.015%w/v; calcium chloride 0.026%w/v; glucoae 0.110%w/v; potassium chloride 0.015%w/v; sodium lactate 0.336%w/v solution for haemodialysis/hae mofiltration intraarterial use, intravenous use
Estonian: 0.026%w/v; glükoos 0.110%w/v; kaaliumkloriid 0.015%w/v; naatriumlaktaat
English: Nutrineal PD4+A.A.1,1% 1,1% amino acids
Estonian: Nutrineal PD4+A.A.1,1
English: 16 February 2012
Estonian: 16. veebruar 2012
English: The viruses have first been inactivated so that they do not cause any disease.
Estonian: Viirused on inaktiveeritud, et nad ei põhjustaks haigusi.
English: The company also presented results of studies in humans, including one main study in 4,902 children.
Estonian: Ettevõte esitas ka inimuuringute tulemused, sealhulgas ühe põhiuuringu tulemused, milles osales 4902 last.
English: The applicant presented data on experimental models from similar vaccines.
Estonian: Taotleja esitas sarnaste vaktsiinide eksperimentaalmudelitest pärinevad andmed.
English: This may help to protect against the disease caused by the influenza viruses.
Estonian: See võib aidata kaitsta haiguse eest, mida gripiviirus põhjustab.
English: There were also concerns about deficiencies in the laboratory tests used to confirm whether patients had influenza or not.
Estonian: Samuti kahtlustati puudujääke laboratoorsetes testides, mille abil tehti kindlaks, kas patsientidel oli gripp või mitte.
English: The study was designed to take place over three flu seasons and looked at the number of cases of influenza that occurred in a season following vaccination.
Estonian: Uuring kavatseti läbi viia kolme gripihooaja jooksul ja see vaatles gripijuhtude arvu, mis esinesid vaktsineerimisele järgnenud hooaja jooksul.
English: Other main concerns were related to inadequate data from the company, including the data provided on children aged between six to nine years, children with health conditions and on revaccination.
Estonian: Muud tõsised probleemid olid seotud ettevõtte esitatud andmetega, mis puudutasid muu hulgas 69-aastasi lapsi, terviseprobleemidega lapsi ja revaktsineerimist.
English: The shortcomings included incorrect data in the dossier submitted to the Agency, which greatly impacted the reliability of the study results.
Estonian: Puuduste hulka kuulusid Euroopa Ravimiametile esitatud toimikus sisaldunud ebakorrektsed andmed, mis mõjutasid oluliselt uuringutulemuste usaldusväärsust.
English: What is Fluad Paediatric?
Estonian: Mis on Fluad Paediatric?
English: The children were given either Fluad Paediatric, another influenza vaccine (Agrippal or Influsplit) or a non-influenza vaccine (Menjugate or Encepur).
Estonian: Lastele anti kas Fluad Paediatricut, muud gripivaktsiini (Agrippal või Influsplit) või mitte-gripivaktsiini (Menjugate või Encepur).
English: Vaccines work by ‘teaching' the immune system (the body's natural defences) how to defend itself against a disease.
Estonian: Vaktsiinid n-ö õpetavad immuunsüsteemi (organismi loomulikke kaitsemehhanisme) kaitsma organismi haiguste eest.
English: The flu strains used to produce the vaccine was to depend on official recommendations for the annual flu season.
Estonian: Vaktsiini tootmiseks kasutatavad gripitüved sõltuvad iga-aastase gripihooaja ametlikest soovitustest.
English: Withdrawal of the marketing authorisation application for Fluad Paediatric (influenza vaccine, surface antigen, inactivated, adjuvanted) EMA/CHMP/114709/2012
Estonian: Müügiloa taotluse tagasivõtmise teave Fluad Paediatric (gripivaktsiin, pinnaantigeen, inaktiveeritud, adjuveeritud) EMA/CHMP/114709/2012
English: The CHMP was particularly concerned by shortcomings in good clinical practice (GCP) that came to light following an inspection of the sites of the main study.
Estonian: Inimravimite komitee oli eriti mures hea kliinilise tava puuduliku järgimise pärast, mis tuli ilmsiks pärast põhiuuringus osalenud uurimiskeskuste inspekteerimist.
English: The
Estonian: Euroopa Liidu amet
English: On 10 February 2012, Novartis Vaccines and Diagnostics officially notified the Committee for Medicinal Products for Human Use (CHMP) that it wishes to withdraw its application for a marketing authorisation for Fluad Paediatric, for the prevention of seasonal influenza in infants and children.
Estonian: 10. veebruaril 2012 teatas Novartis Vaccines and Diagnostics ametlikult inimravimite komiteele oma soovist võtta tagasi vaktsiini Fluad Paediatric müügiloa taotlus.
English: The application was withdrawn after ‘day 180'.
Estonian: Taotluse menetlemine oli kestnud 180 päeva, kui ettevõte taotluse tagasi võttis.
English: The vaccine is the same as a vaccine that is authorised in several EU countries to prevent seasonal flu in the elderly population.
Estonian: Vaktsiin on sama, mis on mitmes ELi riigis heaks kiidetud hooajalise gripi ennetamiseks eakatel.
English: The vaccine contains an ‘adjuvant' to enhance the immune response.
Estonian: Vaktsiin sisaldab immuunvastuse tugevdamiseks adjuvanti.
English: Fluad Paediatric was expected to be used to prevent influenza in infants and children aged from six months to less than nine years.
Estonian: Fluad Paediatricut kavatseti kasutada gripi ennetamiseks 6 kuu kuni 9 aasta vanustel lastel.
English: Therefore, at the time of the withdrawal, the CHMP's conclusion was that the vaccine could not have been approved since the company had not addressed the Committee's main concerns.
Estonian: Seetõttu oli inimravimite komitee müügiloa taotluse tagasivõtmise ajal arvamusel, et vaktsiinile ei saa anda müügiluba, sest ettevõte ei olnud komitee tõstatatud põhiprobleeme piisavalt käsitlenud.
English: When a person is given the vaccine, the immune system recognises the viral parts as ‘foreign' and makes antibodies against them.
Estonian: Kui inimesele manustatakse vaktsiini, peab immuunsüsteem viiruseosi võõraks ja tekitab nende vastu antikehi.
English: This means that the CHMP had evaluated the documentation provided by the company and formulated lists of questions.
Estonian: Inimravimite komitee oli juba hinnanud ettevõtte esitatud dokumente ja koostanud ettevõttele vastamiseks küsimused.
English: Withdrawal of the marketing authorisation application for Fluad Paediatric (influenza vaccine, surface antigen, inactivated, adjuvanted)
Estonian: Müügiloa taotluse tagasivõtmise teave Fluad Paediatric (gripivaktsiin, pinnaantigeen, inaktiveeritud, adjuveeritud)
English: immune system will then be able to produce antibodies more quickly when it is exposed to the viruses again.
Estonian: Kui immuunsüsteem puutub viirustega hiljem uuesti kokku, tekivad antikehad kiiremini.
English: Fluad Paediatric is a vaccine to protect against seasonal influenza.
Estonian: Fluad Paediatric on hooajalise gripi vaktsiin.
English: In its letter notifying the Agency of the withdrawal of application, the company stated that its withdrawal was based on the fact that it was unable to address the concerns of the CHMP within the required timelines.
Estonian: Oma kirjas Euroopa Ravimiametile taotluse tagasivõtmise kohta teatas ettevõte, et tagasivõtmise alus on ettevõtte suutmatus käsitleda nõutavaks tähtajaks inimravimite komitee tõstatatud probleeme.
English: The company informed the CHMP that there are no consequences for people currently included in clinical trials using Fluad Paediatric.
Estonian: Ettevõte teatas inimravimite komiteele, et taotluse tagasivõtmine ei mõjuta Fluad Paediatricu kliinilistes uuringutes osalevaid patsiente.
English: It contains proteins from three inactivated influenza (flu) virus strains.
Estonian: See sisaldab kolme inaktiveeritud gripiviiruse tüve valke.
English: Fluad Paediatric contains proteins from three influenza virus strains.
Estonian: Fluad Paediatric sisaldab kolme inaktiveeritud gripiviiruse tüve valke.
English: After the CHMP had assessed the company's responses to the first round of questions, there were still some unresolved issues.
Estonian: Inimravimite komitee oli esialgsed vastused läbi vaadanud, kuid mõni küsimus oli veel lahendamata.
English: Based on the review of the data and the company's response to the CHMP list of questions, at the time of the withdrawal, the CHMP had several major concerns.
Estonian: Tuginedes esitatud andmete analüüsile ja inimravimite komitee esitatud küsimustele antud vastustele, nägi komitee taotluse tagasivõtmise ajal põhjust ettevaatuseks.
English: How is Fluad Paediatric expected to work?
Estonian: Mis on Fluad Paediatricu eeldatav toime?
English: What was Fluad Paediatric expected to be used for?
Estonian: Milleks kavatseti Fluad Paediatricut kasutada?
English: This summary was last updated on 26/10/2011.
Estonian: Kokkuvõtte viimane uuendus: 26/10/2011.
English: The European Medicines Agency (EMA) will review additional information that will become available according to an agreed timetable and this summary will be updated as necessary.
Estonian: Euroopa Ravimiamet (EMA) vaatab läbi täiendavad andmed, mis saavad kättesaadavaks kokkulepitud ajakava kohaselt, ja vajaduse korral uuendab käesolevat kokkuvõtet.
English: This is acceptable because of the current political and epidemiological situation in Europe with regard to avian
Estonian: See on Euroopa praeguses linnugripiga seotud poliitilises ja epidemioloogilises olukorras vastuvõetav.
English: Because of the current epidemiological situation of avian influenza and the consequent threat to both human and animal health, the Committee recommended the granting of a Marketing Authorisation.
Estonian: Linnugripi praeguse epidemioloogilise olukorra ja sellest tuleneva ohu tõttu nii inimeste kui ka loomade tervisele soovitas komitee anda müügiloa.
English: The vaccine does not contain any ingredients that are likely to pose a risk for consumers of vaccinated
Estonian: Vaktsiin ei sisalda koostisaineid, mis võivad ohustada vaktsineeritud lindude tarbijaid.
English: If you want more information on the basis of the CVMP recommendations, read the Scientific Discussion (also part
Estonian: Kui soovite lisateavet veterinaarravimite komitee soovituste aluse kohta, lugege palun teadusliku arutelu kokkuvõtet (samuti Euroopa avaliku hindamisaruande osa).
English: Inactivated recombinant avian influenza virus
Estonian: Inaktiveeritud rekombinantne linnugripi viirus
English: The virus used for the vaccine is a recombinant virus.
Estonian: Vaktsiinis kasutatav viirus on rekombinantviirus.
English: No field trial is available for this target species.
Estonian: Selle sihtliigi kohta ei ole väliuuringuid korraldatud.
English: The vaccine was assessed in the context of an emergency situation which means that further studies with Poulvac FluFend H5N3 RG are still ongoing and will be assessed.
Estonian: Vaktsiini hinnati hädaolukorra tingimustes, mis tähendab, et Poulvac FluFend H5N3 RG-ga jätkuvad edasised uuringud, mida veel hinnatakse.
English: Laboratory studies were carried out looking at the safety of the vaccine after a single dose, an overdose and a repeated dose regimen.
Estonian: Laboriuuringutes uuriti vaktsiini ohutust pärast ühekordset annust, üleannustamist ja korduva annusega raviskeemi.
English: In the future, if the birds are exposed to the avian flu virus, their immune systems will be able to make those antibodies quicker and this will help them fight the disease.
Estonian: Kui lind puutub hiljem kokku linnugripiviirusega, suudab tema immuunsüsteem moodustada neid antikehasid kiiremini ja see aitab tal haigusega võidelda.
English: The benefit-risk balance may be found in module 6 of this
Estonian: Kasulikkuse ja riski vahelist tasakaalu kirjeldab käesoleva Euroopa avaliku hindamisaruande 6. moodul.
English: • If the circulating avian influenza field virus has a different N component to the N3 included in the vaccine, it may be possible to differentiate between vaccinated and infected birds by using a diagnostic test to detect specific Neuraminidase antibodies.
Estonian: • Kui looduses levival linnugripiviirusel on muu N-komponent kui viiruses sisalduv N3, võib vaktsineeritud ja nakatunud lindude eristamiseks olla võimalik kasutada mõnda diagnostilist testi spetsiifiliste neuraminidaasi antikehade määramiseks.
English: This kind of ‘reassortment' between H and N types happens naturally in the wild but in this case has been carried out in the laboratory to produce a virus with these very specific properties.
Estonian: Sellist Hja N-tüüpi antigeenide „ümbersortimist“ esineb loomulikul kujul ka looduses, kuid käesoleval juhul on seda tehtud laboris mainitud väga spetsiifiliste omadustega viiruse tootmiseks.
English: A field trial
Estonian: • Kanad
English: It has been made using a ‘recombinant DNA technique' (when genes are inserted into an organism) to carry the H5 (haemagglutinin 5) and N3 (neuraminidase 3) antigens.
Estonian: Sellele on lisatud rekombinant-DNA-tehnikaga (mille puhul lisatakse organismile geene) antigeene H5 (hemaglutiniin-5) ja N3 (neuraminidaas-3).
English: The person who gives the vaccine should be careful to avoid
Estonian: Vaktsiini andev inimene peab hoolikalt vältima juhuslikku enese süstimist.
English: The results of studies of a similar vaccine on chickens free of any infection (containing the same ingredients, except for the virus) were also looked at.
Estonian: Vaadeldi ka sarnase vaktsiiniga (sisaldab samu koostisaineid ilma viiruseta) nakkusevabadel kanadel tehtud uuringu tulemusi.
English: The Committee for Medicinal Products for Veterinary Use concluded that the vaccine has been shown to be safe and to be effective in preventing disease in poultry and could be a useful tool in controlling an outbreak of avian influenza infection.
Estonian: Veterinaarravimite komitee jõudis järeldusele, et vaktsiini efektiivsus kodulindude kliinilise haigestumise ennetamiseks on tõendatud ning et see võiks olla kasulik linnugripinakkuse puhkemise tõrjeks.
English: • The studies showed that the birds which receive the vaccine develop antibodies against the H5 subtype of the avian influenza virus.
Estonian: • Uuringud näitasid, et vaktsiini saanud lindudel tekkisid antikehad linnugripiviiruse alatüübi H5 vastu.
English: Birds vaccinated with this vaccine make antibodies against these two chosen antigens.
Estonian: Selle vaktsiiniga vaktsineeritud lindudes tekivad antikehad nende kahe valitud antigeeni vastu.
English: The vaccine is injected intramuscularly (into the breast muscle) in chickens or subcutaneously (under the skin) in ducks, as two doses, 3 weeks apart.
Estonian: Vaktsiini süstitakse kanadele intramuskulaarselt (rinnalihasesse) ja partidele subkutaanselt (naha alla) kahe annusena, kolmenädalase vahega.
English: This strain has been chosen because it protects birds against the virulent H5N1 field strains (cross-protection), while allowing differentiation of vaccinated from infected birds.
Estonian: See tüvi on valitud seepärast, et see kaitseb linde virulentsete looduses esinevate H5N1-tüvede vastu (ristkaitse), võimaldades siiski eristada vaktsineeritud linde nakatunud lindudest.
English: The European Commission granted a marketing authorisation valid throughout the European Union, for Poulvac FluFend H5N3 RG on 01.09.2006.
Estonian: Euroopa Komisjon väljastas Poulvac FluFend H5N3 RG müügiloa, mis kehtib kogu Euroopa Liidu territooriumil, 01.09.2006.
English: Poulvac FluFend H5N3 RG is a vaccine containing an inactivated avian influenza virus H5N3 (inactivated means that the virus has been killed so that it cannot cause the disease anymore).
Estonian: Poulvac FluFend H5N3 RG on inaktiveeritud linnugripiviirust H5N3 sisaldav vaktsiin („inaktiveeritud“ tähendab, et viirus on hävitatud, nii et see ei saa enam haigust tekitada).
English: What are the precautions for the person who gives the medicine or comes
Estonian: Milliseid ettevaatusmeetmeid peab ravimit andev või loomaga kokku puutuv inimene võtma?
English: Vaccinated birds can be differentiated from infected birds by looking for antibodies against the N3 component.
Estonian: Vaktsineeritud linde saab eristada nakatunud lindudest N3-komponendi vastaste antikehade järgi.
English: Poulvac FluFend H5N3 RG is a vaccine used in chickens and ducks to protect against avian influenza.
Estonian: Poulvac FluFend H5N3 RG on vaktsiin, mida kasutatakse kanade ja partide kaitsmiseks linnugripi eest.
English: When it is given to birds, the animals' immune systems (their natural defences) learn how to make antibodies (a special type of protein) to fight the virus.
Estonian: Selle andmisel lindudele õpib linnu immuunsüsteem (looduslik kaitsemehhanism) moodustama viirusega võitlemiseks antikehi (teatavat liiki valku).
English: • The vaccine has been shown to prevent clinical signs and mortality and reduce virus shedding in infected chickens and ducks.
Estonian: • Tõendati, et vaktsiin hoidis nakatunud kanadel ja partidel ära kliiniliste nähtude tekkimist ja suremust ning vähendas viiruse ülekandumist.
English: Poulvac FluFend H5N3 RG is a vaccine.
Estonian: Poulvac FluFend H5N3 RG on vaktsiin.
English: Other information about Poulvac FluFend H5N3 RG:
Estonian: Muu teave Poulvac FluFend H5N3 RG kohta
English: What is the risk associated with Poulvac FluFend H5N3 RG?
Estonian: Millised on Poulvac FluFend H5N3 RG-ga kaasnevad riskid?
English: How does Poulvac FluFend H5N3 RG work?
Estonian: Kuidas Poulvac FluFend H5N3 RG toimib?
English: Poulvac FluFend H5N3 RG has been authorised under “Exceptional Circumstances”.
Estonian: Poulvac FluFend H5N3 RG-le on antud müügiluba erandkorras.
English: Why has Poulvac FluFend H5N3 RG been approved?
Estonian: Miks Poulvac FluFend H5N3 RG heaks kiideti?
English: How has Poulvac FluFend H5N3 RG been studied?
Estonian: Kuidas Poulvac FluFend H5N3 RG-d uuriti?
English: What is Poulvac FluFend H5N3 RG used for?
Estonian: Mis on Poulvac FluFend H5N3 RG?
English: EMA/CHMP/906885/2011
Estonian: EMA/CHMP/906885/2011 EMEA/H/C/002068
English: Ioa was investigated in two main studies involving a total of 4,433 women aged 18 to 50 years old.
Estonian: Ioat vaadeldi kahes põhiuuringus, kus osales kokku 4433 naist vanuses 18−50 aastat.
English: The full EPAR for Ioa can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Estonian: Euroopa avaliku hindamisaruande täistekst Ioa kohta on ameti veebilehel: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: What is the risk associated with Ioa?
Estonian: Mis riskid Ioaga kaasnevad?
English: No clinical study data on Ioa are available in adolescents under 18 years old.
Estonian: Ioa kasutamise kohta alla 18-aastastel noortel ei ole avaldatud kliiniliste uuringute andmeid.
English: The main measure of effectiveness was the number of women aged 18 to 35 who became pregnant during or shortly after treatment, expressed in terms of a pregnancy rate using the ‘Pearl Index'.
Estonian: Efektiivsuse põhinäitaja oli ravi ajal või varsti pärast ravi rasestunud 18−35-aastaste naiste arv ning seda väljendati raseduste määrana Pearli indeksi abil.
English: The European Commission granted a marketing authorisation valid throughout the European Union for
Estonian: Euroopa Komisjon andis Ioa müügiloa, mis kehtib kogu Euroopa Liidu territooriumil, 16. novembril
English: In women aged 18 to 35, the Pearl Index was around 0.4 with Ioa and 0.8 with the comparator medicine in the first study, and around 1.2 with Ioa and 1.9 with the comparator medicine in the
Estonian: 18−35-aastaste naiste seas oli Pearli indeks esimeses uuringus Ioaga ligikaudu 0,4 ja võrdlusravimiga 0,8 ning teises uuringus Ioaga ligikaudu 1,2 ja võrdlusravimiga 1,9.
English: The CHMP decided that the benefits of Ioa are greater than its risks and recommended that it be given
Estonian: Inimravimite komitee otsustas, et Ioa kasulikkus on suurem kui sellega kaasnevad riskid, ja soovitas anda ravimi müügiloa.
English: For more information about treatment with Ioa, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Estonian: Kui vajate Ioaga toimuva ravi kohta lisateavet, lugege pakendi infolehte (mis on samuti Euroopa avaliku hindamisaruande osa) või pöörduge oma arsti või apteekri poole.
English: This is a summary of the European public assessment report (EPAR) for Ioa.
Estonian: See on ravimi Ioa Euroopa avaliku hindamisaruande kokkuvõte.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Ioa.
Estonian: Selles selgitatakse, kuidas inimravimite komitee hindas ravimit ja otsustas toetada müügiloa andmist; samuti esitatakse komitee soovitused, kuidas ravimit kasutada.
English: It must not be used when a woman has, or has had, venous or arterial thrombosis (blood clots in the veins or arteries) including a stroke or a heart attack or when a woman has some of the risk factors for thrombosis (severe high blood pressure, diabetes with damage to the blood vessels or high cholesterol levels).
Estonian: Samuti ei tohi seda kasutada juhul, kui patsiendil on või on olnud venoosne või arteriaalne tromboos (verehüübed veenides või arterites), sealhulgas insult või südameinfarkt, või juhul, kui tal esineb mõni tromboosi riskitegur (väga kõrge vererõhk, diabeet koos veresoonte kahjustustega või suur kolesteroolisisaldus).
English: The most frequent side effects with Ioa (seen in more than 1 user in 10) are acne and changes to menstrual periods (e.g. absence or irregularity).
Estonian: Ioa kõige sagedamad kõrvalnähud (esinenud enam kui 1 patsiendil 10st) on akne ning menstruaaltsükli muutused (nt menstruatsiooni puudumine või ebaregulaarsus).
English: Ioa is a contraceptive pill.
Estonian: Ioa on kontratseptiiv (rasestumisvastane tablett).
English: How has Ioa been studied?
Estonian: Kuidas Ioat uuriti?
English: Estradiol is the same as a hormone naturally produced by the ovaries during a menstrual cycle.
Estonian: Östradiool on hormoon, mis looduslikult tekib menstruaaltsükli jooksul munasarjades.
English: One tablet a day is taken for as long as contraception is required, starting with an active tablet on the first day of the cycle.
Estonian: Ioat manustatakse aja vältel, mil rasedusest soovitakse hoiduda, üks tablett ööpäevas, alustades toimeainet sisaldava tabletiga menstruaaltsükli esimesel päeval.
English: The effects of Ioa were first tested in experimental models before being studied in humans.
Estonian: Enne inimuuringuid kontrolliti Ioa toimet muude katsetega.