FrancophonIA/ELRC3.0 huggingface dataset:
English: Levodopa/carbidopa should be administered cautiously to patients with ischemic heart disease, severe cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease, or history of peptic ulcer disease (because of the possibility of upper gastro-intestinal haemorrhage) and a history of convulsions.
Croatian: Levodopu/karbidopu treba primjenjivati uz oprez u bolesnika s ishemijskom bolešću srca, teškom kardiovaskularnom ili plućnom bolešću, bronhalnom astmom, bubrežnom, jetrenom ili endokrinom bolešću, kao i u bolesnika s anamnezom peptičkog ulkusa (zbog mogućnosti hemoragije iz gornjeg gastrointestinalnog trakta) i konvulzija.
English: In vivo, co-administration of Numient with up to 40% volume-to-volume (v/v) alcohol did not result in dosedumping of levodopa or carbidopa.
Croatian: In vivo istodobna primjena Numienta s alkoholom do 40 % volumenske koncentracije nije dovela do nakupljanja doze levodope ili karbidope.
English: Phaeochromocytoma.
Croatian: Feokromocitom.
English: The starting dose is one capsule containing 95 mg of levodopa and 23.75 mg carbidopa three times daily (TID) for the first three days; this may be increased to a dose of one modified-release hard capsule containing 145 mg of levodopa and 36.25 mg carbidopa three times daily from Day 4 of treatment.
Croatian: Početna doza je jedna kapsula koja sadrži 95 mg levodope i 23,75 mg karbidope tri puta dnevno (TID) u prva tri dana; može se povećati na dozu od jedne tvrde kapsule s prilagođenim oslobađanjem koja sadrži 145 mg levodope i 36,25 mg karbidope tri puta dnevno od 4. dana liječenja.
English: The ingredients in the hard capsule shell are indigo carmine (E132) lake, yellow iron oxide (E172), titanium dioxide (E171) and gelatine
Croatian: Sastojci u ovojnici tvrde kapsule su indigo karmin (E132) lake, žuti željezov oksid (E172), titanijev dioksid (E171) i želatina
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Croatian: U slučaju bilo kakvih dodatnih pitanja u vezi s primjenom ovog lijeka, obratite se svom liječniku ili ljekarniku.
English: Levodopa-naïve patients with Parkinson's disease APEX-PD
Croatian: Bolesnici s Parkinsonovom bolešću koji nisu liječeni levodopom APEX-PD
English: Carbidopa inhibits decarboxylation of peripheral levodopa.
Croatian: Karbidopa inhibira dekarboksilaciju periferne levodope.
English: The dose of the modified-release levodopa/carbidopa capsule medicinal product may need to be decreased with concomitant use of COMT inhibitors.
Croatian: Dozu kapsule lijeka s prilagođenim oslobađanjem levodope/karbidope može biti potrebno smanjiti prilikom istodobne primjene inhibitora COMT-a.
English: Table 4: Mean change from baseline in UPDRS Part II plus Part III score at week 30 (or at early termination) in levodopa naïve patients with Parkinson's disease (APEX-PD)
Croatian: Tablica 4: Srednja vrijednost promjena od početne vrijednosti u rezultatu dijela II i dijela III UPDRSa u 30. tjednu (ili kod ranog prekida) u bolesnika oboljelih od Parkinsonove bolesti koji nisu liječeni levodopom (APEX-PD)
English: Adverse reactions are listed below by system organ class (SOC) and frequency (Table 3).
Croatian: U nastavku su navedene nuspojave prema klasifikaciji organskih sustava i učestalosti (Tablica 3).
English: If any of this happens, contact your doctor immediately an eye condition called chronic wide angle glaucoma, because your dose may need to be adjusted and the pressure in your eyes may need to be monitored melanoma or suspicious skin lesion a heart attack, heart beat problems, circulation or breathing problems kidney or liver problems an ulcer in your gut (called ‘duodenal' or ‘peptic ulcer') an endocrine (hormone) disease bronchial asthma obsessive behaviour(s) convulsions low blood pressure or feeling dizzy when getting up new or increased abnormal body movements (dyskinesias)
Croatian: Ako se dogodi bilo što od toga, odmah se obratite svojem liječniku bolest oka koja se naziva kronični glaukom širokog kuta, budući da tada Vašu dozu možda treba prilagoditi i pratiti očni tlak melanom ili sumnjive kožne lezije srčani udar, probleme s otkucajima srca, cirkulacijom ili disanjem bubrežne ili jetrene probleme vrijed (čir) u crijevima (koji se naziva „vrijed na dvanaesniku“ ili „peptički ulkus“) endokrinu (hormonalnu) bolest bronhalnu astmu opsesivno(a) ponašanje(a) konvulzije snižen krvni tlak ili osjećaj omaglice kod ustajanja nove ili pojačane abnormalne pokrete tijela (diskinezije)
English: Numient contains two different medicines called levodopa and carbidopa in one hard capsule.
Croatian: Numient sadrži dva različita lijeka koji se nazivaju levodopa i karbidopa u jednoj tvrdoj kapsuli. levodopa se u Vašem mozgu pretvara u tvar koja se naziva „dopamin“.
English: Following administration of the modified-release hard capsule contents sprinkled over a small quantity (e.g., 2 tablespoons) of soft food such as apple sauce, yoghurt, or pudding, the rate and extent of absorption of levodopa was similar to that observed in the fasted state.
Croatian: Nakon primjene sadržaja tvrde kapsule s prilagođenim oslobađanjem posutog na malu količinu (npr. 2 velike žlice) mekane hrane kao što je kaša od jabuke, jogurt ili puding, brzina i opseg apsorpcije levodope bili su slični vrijednostima zapaženima natašte.
English: Administration with a high-fat, high-calorie meal delays levodopa absorption by up to 2 hours (see section 4.2).
Croatian: Primjena s obrokom s visokim udjelom masti i kalorija odgađa apsorpciju levodope do 2 sata (vidjeti dio 4.2).
English: Patients taking these medicinal products together with levodopa/carbidopa should be monitored carefully for loss of therapeutic response.
Croatian: Bolesnike koji uzimaju te lijekove zajedno s levodopom/karbidopom mora se pažljivo pratiti zbog gubitka terapijskog odgovora.
English: Numient has not been studied in patients with hepatic impairment.
Croatian: Numient nije ispitivan u bolesnika s oštećenjem jetre.
English: Indigo carmine (E132), lake Yellow iron oxide (E172) Titanium dioxide (E171) Gelatine
Croatian: Ovojnica kapsule indigo karmin (E132), lake žuti željezov oksid (E172) titanijev dioksid (E171) želatina
English: Therefore, Numient should not be taken at the same time as high protein meals.
Croatian: Zato Numient ne treba uzimati istodobno s obrocima koji sadrže visok udio bjelančevina.
English: If general anaesthesia is required, the modified-release levodopa/carbidopa capsule medicinal product may be continued as long as the patient is permitted to take oral medicinal products.
Croatian: Ako je potrebna opća anestezija, uzimanje kapsule lijeka s prilagođenim oslobađanjem koja sadrži levodopu/karbidopu može se nastaviti sve dok je bolesniku dozvoljeno uzimati lijekove kroz usta.
English: Therefore, patients must be monitored carefully when the dose of levodopa/carbidopa is reduced abruptly or discontinued, especially if the patient is receiving antipsychotics (see section 4.2).
Croatian: Stoga bolesnike treba pažljivo pratiti kada se doza levodope/karbidope naglo smanjuje ili prekida, naročito ako bolesnik prima antipsihotike (vidjeti dio
English: Sporadic cases of a symptom complex resembling neuroleptic malignant syndrome (NMS) have been associated with dose reductions and withdrawal of levodopa/carbidopa containing medicinal products.
Croatian: Sporadični slučajevi kompleksa simptoma nalik neuroleptičkom malignom sindromu (NMS) povezuju se sa smanjenjem doze i povlačenjem lijekova koji sadrže levodopu/karbidopu.
English: The ingredients in the ink are SB-6018 blue ink, shellac (E904), propylene glycol, and indigo carmine (E132) lake
Croatian: Sastojci u tinti su plava tinta SB-6018, šelak (E904), propilen glikol i indigo karmin (E132) lake
English: Total daily dose of levodopa in immediate release levodopa/DDC inhibitor (mg)
Croatian: Ukupna dnevna doza levodope u lijeku s trenutnim oslobađanjem koji sadrži levodopu/inhibitor DDC (mg)
English: pruritus (see section 4.3) purpura, urticaria (see section 4.3), hair loss, exanthema, dark sweat
Croatian: Henoch-Schönleinova purpura, urtikarija (vidjeti dio 4.3), gubitak kose, egzantem, taman znoj
English: Melanoma (see section
Croatian: melanom (vidjeti dio 4.4)
English: Products containing ferrous sulphate should be administered separately from levodopa/carbidopa, with the longest possible time interval between administrations (see section 4.5).
Croatian: Proizvodi koji sadrže željezov sulfat moraju se primijeniti odvojeno od levodope/karbidope, s najduljim mogućim vremenskim razmakom između primjena (vidjeti dio 4.5).
English: Patients taking these medicinal products with levodopa/carbidopa should be carefully monitored for loss of therapeutic response.
Croatian: Bolesnike koji uzimaju ove lijekove zajedno s levodopom/karbidopom mora se pažljivo pratiti zbog gubitka terapijskog odgovora.
English: Numient 245 mgd)
Croatian: Numient 245 mg d)
English: Abbreviations: CGI-C: clinical global impression of change from baseline; CI: confidence interval; IR: immediate release; LCE: Levodopa/Carbidopa/Entacapone; L-dopa†: Levodopa/Carbidopa; LS: least squares; PD: Parkinson's disease; SD: standard deviation; N/A: not available; hrs: hours; yrs: years.
Croatian: Clinical Global Impression of Change from Baseline); CI: interval pouzdanosti: IR: trenutno otpuštanje; LCE: levodopa/karbidopa/entakapon; L-dopa†: Levodopa/karbidopa; LS: najmanji kvadrati; PD: Parkinsonova bolest; SD: standardna devijacija; N/A: nije raspoloživo; *U ispitivanju ADVANCE-PD korišten je model Analize kovarijance (ANCOVA) za kraj ispitivanja s liječenjem i centrima kao glavnim učincima, a rok interakcije za liječenje po centru i početnoj vrijednosti kao kovarijancom.
English: This may cause difficulties in breathing or swallowing Your muscles get very rigid or jerk violently, you get tremors, agitation, confusion, fever, rapid pulse, or wide fluctuations in your blood pressure.
Croatian: Vaši mišići postanu jako ukočeni ili se snažno trzaju, pojavilo se nevoljno drhtanje, uznemirenost, smetenost, vrućica, ubrzani puls ili izrazite promjene krvnog tlaka.
English: No dose adjustment of the modified-release levodopa/carbidopa medicinal product is required for elderly patients.
Croatian: Nije potrebna prilagodba doze lijeka levodopa/karbidopa s prilagođenim oslobađanjem u starijih bolesnika.
English: The following side effects have also been reported but the chance that they will occur is unknown: Low blood cell counts (white blood cells, platelets) Drug abuse of certain medicines used to treat Parkinson's Disease Suicide attempt, feeling disoriented, increased sexual feelings Severe prolonged abnormal eye movements, Horner's Syndrome (drooping eyelid, small pupil and decreased sweating on one side of the face), eyelid twitching Abnormal breathing pattern
Croatian: Sljedeće nuspojave također su prijavljene, ali nije poznata mogućnost njihovog nastanka: nizak broj krvnih stanica (bijele krvne stanice, trombociti) zlouporaba nekih lijekova za liječenje Parkinsonove bolesti pokušaj samoubojstva, osjećaj dezorijentiranosti, povećani seksualni osjećaji teški produljeni abnormalni pokreti očiju, Hornerov sindrom (spušteni kapak, uska zjenica i smanjeno znojenje na jednoj strani lica), trzanje kapka abnormalan obrazac disanja pretjerano stvaranje sline ili tamno obojena slina, škrgutanje zubima, štucanje gubitak kose, osip (uključujući težak osip pod nazivom Henoch-Schönleinova purpura), tamno obojeni znoj
English: Modified-release levodopa/carbidopa should be administered cautiously to patients with severe renal impairment (see section 4.2).
Croatian: Levodopa/karbidopa s prilagođenim oslobađanjem mora se primjenjivati uz oprez u bolesnika s teškim oštećenjem bubrega (vidjeti dio 4.2).
English: Patients were not allowed to receive supplemental levodopa or catechol-O-methyl transferase (COMT) inhibitors.
Croatian: Bolesnicima nije dozvoljeno dodatno primanje levodope ili inhibitora katehol-O-metil transferaze (COMT).
English: 750 to 949
Croatian: 750 do 949
English: The effect of co-administration of this modified-release levodopa/carbidopa capsule product and COMT inhibitors such as entacapone has not been studied.
Croatian: Učinak istodobne primjene ove kapsule s prilagođenim oslobađanjem levodope/karbidope i inhibitora COMT-a kao što je entakapon nije ispitivan.
English: When patients are initially converted from immediate release levodopa/DDC inhibitor medicinal products to Numient, the dosing conversion guidelines provided in Table 1 are recommended for initial dosing.
Croatian: Kada bolesnici u početku prelaze s lijekova s trenutnim oslobađanjem koji sadrže levodopu/DDC inhibitor na Numient, za početno doziranje preporučene su smjernice za pretvaranje doze navedene u Tablici 1.
English: Swallow the medicine/food mixture completely and immediately without chewing and do not store for future use Take the capsules at regular time intervals according to your doctor's instructions Do not change the times at which you take your capsules or take any other medicines for Parkinson's disease without first consulting your doctor.
Croatian: Progutajte mješavinu lijek/hrana u cijelosti i odmah, bez žvakanja, i ne ostavljajte za kasniju uporabu Uzmite kapsule u redovnim vremenskim intervalima prema uputama Vašeg liječnika
English: Each capsule contains 95 mg of levodopa and 23.75 mg of carbidopa (as monohydrate).
Croatian: Svaka kapsula sadrži 95 mg levodope i 23,75 mg karbidope (u obliku hidrata).
English: Renal excretion of intact levodopa accounts for only about 10% of clearance.
Croatian: Izlučivanje nepromijenjene levodope putem bubrega iznosi samo oko 10 % klirensa.
English: Patients were not allowed to receive supplemental levodopa/carbidopa or catechol-O-methyl transferase (COMT) inhibitor medicinal products during the trial.
Croatian: Bolesnicima nije dozvoljeno dodatno primanje lijekova koji sadrže levodopu/karbidopu ili inhibitore katehol-O-metil transferaze (COMT) tijekom ispitivanja.
English: Ink
Croatian: Tinta
English: The dosing frequency may be changed from three times a day to a maximum of five times a day if sufficient symptomatic control is not observed.
Croatian: Ako nije opažena dovoljna kontrola simptoma, učestalost doziranja može se promijeniti s tri puta dnevno na najviše pet puta dnevno.
English: Modified-release hard capsule
Croatian: Tvrde kapsule s prilagođenim oslobađanjem
English: Musculoskeletal and connective tissue disorders
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva spazmi mišića
English: 550 to 749
Croatian: 550 do 749
English: Following administration of the modified-release hard capsule contents sprinkled over a small quantity of soft food such as apple sauce, the rate and extent of absorption of levodopa was similar to that observed in the fasted state.
Croatian: Nakon primjene sadržaja tvrde kapsule s prilagođenim oslobađanjem posutog na malu količinu mekane hrane kao što je kaša od jabuke, stopa i opseg apsorpcije levodope slični su onima opaženim natašte.
English: Sporadic cases of a symptom complex resembling NMS have been reported in association with dose reductions or withdrawal of levodopa/carbidopa medicinal products.
Croatian: Sporadični slučajevi kompleksa simptoma nalik na NMS prijavljeni su u vezi sa smanjenjima doze ili povlačenjem lijekova koji sadrže levodopu/karbidopu.
English: Table 1: Guidelines for initial conversion from immediate release (IR) levodopa/DDC inhibitor medicinal products to Numient in Parkinson's disease patients.
Croatian: Tablica 1: Smjernice za početni prelazak s lijeka s trenutnim oslobađanjem (IR, engl. immediate release) koji sadrži levodopu/DDC inhibitor na Numient u oboljelih od Parkinsonove bolesti.
English: 3 hard capsules 145 mg/36.25 mg TID
Croatian: 3 tvrde kapsule od 145 mg/36,25 mg TID
English: Products containing ferrous sulphate and levodopa/carbidopa should be administered separately with the longest possible time interval between administrations (see section 4.2).
Croatian: Proizvodi koji sadrže željezov sulfat moraju se primjenjivati odvojeno od levodope/karbidope, s najduljim mogućim vremenskim razmakom između primjena (vidjeti dio 4.2).
English: Inability to resist the impulse to perform an action that could be harmful, which may include: Strong impulse to gamble excessively despite serious personal or family consequences Altered or increased sexual interest and behaviour of significant concern to you or to others, for example, an increased sexual drive
Croatian: Možete također imati sljedeće nuspojave: - Nemogućnost odupiranja impulsu (porivu) za obavljanje određene radnje koja može biti štetna, što može uključivati: snažan impuls za prekomjernim kockanjem usprkos teškim osobnim ili obiteljskim posljedicama promijenjena ili pojačana spolna želja i ponašanje koje značajno zabrinjava Vas i druge, npr. pojačan seksualni nagon nekontrolirano prekomjerno kupovanje ili trošenje neumjerenost u jelu (uzimanje velikih količina hrane u kratkom vremenskom razdoblju) ili kompulzivno (prisilno) uzimanje hrane (uzimanje hrane u količini većoj nego što je uobičajeno i više od količine koja zadovoljava glad)
English: Periodic evaluation of hepatic, haematopoietic, cardiovascular and renal function is recommended during extended therapy.
Croatian: Tijekom produljene terapije preporučuje se povremena procjena jetrene, hematopoetske, kardiovaskularne i bubrežne funkcije.
English: subcutaneous tissue disorders hyperhidrosis, rash (see section 4.3)
Croatian: Poremećaji kože i potkožnog tkiva navale vrućine, hiperhidroza, osip (vidjeti dio 4.3)
English: 3 hard capsules 245 mg/61.25 mg TID 4 hard capsules 245 mg/61.25 mg TID
Croatian: 3 tvrde kapsule 245 mg/61,25 mg TID 4 tvrde kapsule 245 mg/61,25 mg TID
English: Bleeding in your stomach or intestines which may be seen as blood in your faeces or darkened faeces An allergic reaction, the signs of which may include hives (nettle rash), itching, rash, swelling of your face, lips, tongue or throat.
Croatian: Ako imate bilo koji od sljedećih simptoma tijekom liječenja Numientom, odmah kontaktirajte svog liječnika: krvarenje u želucu ili crijevima koje se može vidjeti kao krv u stolici ili tamna stolica alergijsku reakciju čiji znakovi uključuju koprivnjaču (urtikariju), svrbež, osip, oticanje lica, usana, jezika ili grla.
English: Oculogyric crises, activation of latent Horner's syndrome, blepharospasm
Croatian: Poremećaji oka zamućen vid, diplopija, midrijaza okulogirna kriza, aktivacija latentnog Hornerovog sindroma, blefarospazam
English: Numient has not been studied in patients with renal impairment.
Croatian: Numient nije ispitivan u bolesnika s oštećenjem bubrega.
English: Cardiac rhythm disordersb) (see section
Croatian: Srčani poremećaji poremećaji srčanog ritmab) (vidjeti dio palpitacije
English: 25 modified-release hard capsules 100 modified-release hard capsules 240 modified-release hard capsules
Croatian: OBLIK I SADRŽAJ 25 tvrdih kapsula s prilagođenim oslobađanjem 100 tvrdih kapsula s prilagođenim oslobađanjem 240 tvrdih kapsula s prilagođenim oslobađanjem
English: 2 hard capsules 245 mg/61.25 mg TID
Croatian: 2 tvrde kapsule 245 mg/61,25 mg TID
English: CNS effects and mental disturbances
Croatian: Učinci na središnji živčani sustav (SŽS) i mentalni poremećaji
English: The primary efficacy endpoint was the mean change from baseline of the Unified Parkinson's Disease Rating Scale (UPDRS) Part II (activities of daily living) score plus Part III motor score at week 30 or early termination.
Croatian: Primarni ishod učinkovitosti bila je srednja vrijednost promjene od početne vrijednosti rezultata komponente dnevnih aktivnosti (dio II) plus komponente motoričkog pregleda (dio III) prema Ujedinjenoj ljestvici za ocjenu Parkinsonove bolesti (engl.
English: COMT inhibitors
Croatian: Inhibitori COMT-a
English: Converting patients from other levodopa/ dopa-decarboxylase (DDC) inhibitor (carbidopa or benserazide) immediate release medicinal products to Numient
Croatian: Prelazak bolesnika s drugih lijekova s trenutnim oslobađanjem koji sadrže levodopu/ inhibitor dopadekarboksilaze (DDC) (karbidopa ili benzerazid) na Numient
English: Figure 1: Mean concentration-time profiles of levodopa plasma concentrations in 22 adults following a single oral dose of 2 Numient 195 mg levodopa/48.75 mg carbidopa capsules
Croatian: Slika 1: Srednja vrijednost profila koncentracija-vrijeme koncentracije levodope u plazmi u 22 odrasla ispitanika nakon pojedinačne peroralne doze 2 kapsule
English: Numient should be taken approximately every 6 hours no more than 5 times a day Take this medicine by mouth with a glass of water.
Croatian: Numient se mora uzimati otprilike svakih 6 sati najviše 5 puta na dan.
English: Unchanged carbidopa accounts for 30% of the total urinary excretion.
Croatian: Nepromijenjena levodopa iznosi oko 30 % ukupnog izlučivanja mokraćom.
English: Elevated urea nitrogen, alkaline phosphatases; positive Coomb's test; leucocytes, and bacteria in the urine a) Adverse reactions not observed in the clinical development of Numient, but reported for other levodopa/carbidopa medicinal products.
Croatian: Pretrage povišene vrijednosti AST, ALT, LDH, bilirubina, šećera u krvi, kreatinina, mokraćne kiseline; snižene vrijednosti hemoglobina i hematokrita; krv u mokraći povišene vrijednosti ureje, alkalne fosfataze; pozitivan Coombsov test; leukociti i bakterije u mokraći a) Nuspojave nisu opažene u kliničkom razvoju Numienta, ali su prijavljene kod drugih lijekova s levodopom/karbidopom.
English: Patients should be observed carefully if abrupt reduction or discontinuation of the modified-release levodopa/carbidopa capsule medicinal product is required, especially if the patient is receiving antipsychotics (see section 4.4).
Croatian: Bolesnike se mora pažljivo motriti ako je potrebno naglo smanjenje ili prekid uzimanja kapsule lijeka s prilagođenim oslobađanjem koja sadrži levodopu/karbidopu, posebno ako bolesnik prima antipsihotike (vidjeti dio
English: 3 hard capsules 195 mg/48.75 mg TID
Croatian: 3 tvrde kapsule 195 mg/48,75 mg TID
English: A high-fat, high-calorie meal delays the absorption of levodopa by two hours.
Croatian: Visokokalorični obrok s visokim udjelom masti odgađa apsorpciju levodope do dva sata.
English: carbidopa belongs to a group of medicines called ‘aromatic amino acid decarboxylase inhibitors'.
Croatian: Dopamin pomaže smanjiti simptome Vaše Parkinsonove bolesti. karbidopa pripada grupi lijekova koji se nazivaju „inhibitori dekarboksilaze aromatskih aminokiselina“.
English: Table 2: Guidelines for initial conversion from immediate release levodopa/DDC inhibitor plus catechol-Omethyl transferase (COMT) inhibitors (such as entacapone) to Numient in Parkinson's disease patients Total daily dose of levodopa (mg) in levodopa/DDC inhibitor/entacapone
Croatian: Tablica 2: Smjernice za početni prelazak s lijekova s trenutnim oslobađanjem koji sadrže levodopu/ DDC inhibitor i inhibitore katehol-O-metil transferaze (COMT) (kao što je entakapon) na Numient u oboljelih od Parkinsonove bolesti
English: Modified-release levodopa/carbidopa should be administered cautiously to patients with severe hepatic impairment.
Croatian: Levodopa/karbidopa s prilagođenim oslobađanjem mora se primjenjivati uz oprez u bolesnika s teškim oštećenjem jetre.
English: System organ class Very Common
Croatian: Klasifikacija organskih sustava
English: Patients continued on stable concomitant anti-Parkinson medicinal product.
Croatian: Bolesnici su nastavili stalnu istodobnu primjenu lijeka protiv Parkinsonove bolesti.
English: Unknown a)
Croatian: Nepoznatoa)
English: “Off” time (hrs)*
Croatian: Vrijeme (Sati)
English: Fall, peripheral oedema, non-cardiac chest pain, asthenia, fatigue
Croatian: Opći poremećaji i reakcije na mjestu primjene pad, periferni edem, bol u prsima koja nije srčana, astenija, umor malaksalost
English: Levodopa/Carbidopa
Croatian: Numienta su levodopa i karbidopa
English: Converting patients specifically from other levodopa/DDC inhibitor modified-release medicinal products to Numient
Croatian: Bolesnici koji izričito prelaze s drugih lijekova s prilagođenim oslobađanjem koji sadrže levodopu/DDC inhibitor na Numient