FrancophonIA/ELRC3.0 huggingface dataset:
English: This may be more likely with long-term HIV treatment, more severe damage to the immune system, being overweight, or the use of alcohol or medicines called corticosteroids.
Croatian: Njena je pojava vjerojatnija u slučaju dugotrajnog liječenja HIV-a, težeg oštećenja imunološkog sustava, prekomjerne težine te uzimanja alkohola ili lijekova koji se zovu kortikosteroidi.
English: Sildenafil to treat a heart and lung disorder called pulmonary arterial hypertension.
Croatian: Sildenafil za liječenje srčanog i plućnog poremećaja koji se zove plućna arterijska hipertenzija.
English: In vitro experiments with human liver microsomes (HLMs) indicate that darunavir primarily undergoes oxidative metabolism.
Croatian: In vitro ispitivanja na mikrosomima ljudske jetre pokazuju da darunavir primarno prolazi kroz oksidacijski metabolizam.
English: MedDRA system organ class Frequency category
Croatian: Organski sustav prema MedDRA klasifikaciji Kategorija učestalosti
English: What you need to know before you take Symtuza
Croatian: Što morate znati prije nego počnete uzimati lijek Symtuza
English: Symtuza is indicated for use as a complete regimen for the treatment of HIV-1 infection and should not be administered with other antiretroviral products (see section 4.5).
Croatian: Lijek Symtuza je indiciran za primjenu kao cjeloviti režim liječenja HIV-1 infekcije i ne smije se primjenjivati s drugim antiretrovirusnim lijekovima (vidjeti dio 4.5).
English: Medicinal products that strongly affect P-gp activity and BCRP may lead to changes in tenofovir alafenamide absorption.
Croatian: Lijekovi koji jako utječu na aktivnost P-gp-a i BCRP-a mogu dovesti do promjena u apsorpciji tenofoviralafenamida.
English: Additional adverse drug reactions only seen with darunavir/ritonavir in other trials or postmarketing experience
Croatian: Dodatne nuspojave zabilježene samo uz darunavir/ritonavir u drugim ispitivanjima ili nakon stavljanja lijeka u promet
English: However, tenofovir disoproxil reduced the viability index and weight of pups in a peri-postnatal toxicity study at maternally toxic doses.
Croatian: Ipak, tenofovirdizoproksil je smanjio indeks preživljenja i težinu mladunčadi u perinatalnim i postnatalnim ispitivanjima toksičnosti pri dozama toksičnima za majku.
English: Limited PK information is available in the elderly (age ≥ 65 years of age) for Symtuza as well as its individual components.
Croatian: Dostupne su ograničene informacije o farmakokinetici u starijih (starost ≥ 65 godina) za lijek Symtuza, kao i za njegove pojedine komponente.
English: Non-clinical studies of tenofovir alafenamide in rats and dogs revealed bone and kidney as the primary target organs of toxicity.
Croatian: Neklinička ispitivanja tenofoviralafenamida u štakora i pasa otkrila su da su kost i bubreg primarni ciljni organi toksičnog djelovanja.
English: Protocol Defined Rebound Rate (95% CI)
Croatian: Stopa protokolom definiranog virološkog povrata (95% CI)
English: There have been reports of increased spontaneous bleeding in haemophiliac patients receiving antiretroviral protease inhibitors (see section 4.4).
Croatian: Prijavljeno je pojačano spontano krvarenje u bolesnika s hemofilijom koji su primali antiretrovirusne inhibitore proteaze (vidjeti dio 4.4).
English: In vitro selection of darunavir-resistant virus from wild type HIV-1 was lengthy (> 3 years).
Croatian: Izdvajanje virusa rezistentnog na darunavir iz virusa HIV-1 divljeg tipa in vitro trajalo je dugo (> 3 godine).
English: Although most rashes are mild and disappear after a while as treatment is continued, a rash can occasionally be severe or potentially life-threatening.
Croatian: Premda je osip u većini slučajeva blag i povlači se s nastavkom liječenja, ponekad može biti ozbiljan ili po život opasan.
English: Total Phase 3
Croatian: Ukupno u ispitivanjima faze 3
English: Patients were on a stable ARV regimen (for at least 6 months), consisting of a boosted protease inhibitor [either darunavir once daily or atazanavir (both boosted with ritonavir or cobicistat), or lopinavir with ritonavir] combined with emtricitabine and TDF.
Croatian: Bolesnici su bili na stabilnom antiretrovirusnom liječenju (barem 6 mjeseci), koje se sastojalo od pojačanog inhibitora proteaze [bilo darunavira jedanput na dan ili atazanavira (oboje pojačani s ritonavirom ili kobicistatom), ili lopinavira s ritonavirom] kombiniranog s emtricitabinom i TDF.
English: It is recommended that the international normalised ratio (INR) be monitored when warfarin is co-administered with Symtuza.
Croatian: Preporučuje se praćenje internacionalnog normaliziranog omjera (INR) kada se varfarin primjenjuje istodobno s lijekom Symtuza.
English: DRV/COBI +F/TDF N = 363
Croatian: DRV/KOBI +F/TDF N = 363
English: The film-coating contains polyethylene glycol (macrogol), polyvinyl alcohol (partially hydrolyzed), talc, titanium dioxide and yellow ferric oxide.
Croatian: Film ovojnica sadrži polietilenglikol (makrogol), poli(vinilni alkohol) (djelomično hidroliziran), talk, titanijev dioksid i žuti željezov oksid.
English: Tenofovir is eliminated from the body by the kidneys by both glomerular filtration and active tubular secretion.
Croatian: Tenofovir se eliminira iz tijela putem bubrega glomerularnom filtracijom i aktivnom tubularnom sekrecijom.
English: If these anti-depressants are to be used with Symtuza clinical monitoring is recommended and a dose adjustment of the anti-depressant may be needed.
Croatian: Ako se ovi antidepresivi uzimaju s lijekom Symtuza preporučuje se kliničko praćenje i možda će biti potrebno prilagoditi dozu antidepresiva.
English: When your supply of Symtuza starts to run low, get more from your doctor or pharmacist.
Croatian: Kad Vam se zaliha lijeka Symtuza približi kraju, nabavite novu količinu od svog liječnika ili ljekarnika.
English: Overall, 22% had baseline plasma HIV-1 RNA > 100,000 copies/mL.
Croatian: Sveukupno je 22% bolesnika imalo plazmatsku vrijednost HIV-1 RNK > 100 000 kopija/ml.
English: Careful patient monitoring and dose adjustment of metformin is recommended in patients who are taking Symtuza.
Croatian: Preporučuje se pažljivo praćenje bolesnika i prilagodba doze metformina u bolesnika koji uzimaju lijek Symtuza.
English: • a reaction called DRESS [severe rash, which may be accompanied by fever, fatigue, swelling of the face or lymph glands, increase of eosinophils (type of white blood cells), effects on liver, kidney or lung].
Croatian: • reakcija koja se naziva DRESS [težak osip, koji može biti praćen vrućicom, umorom, oticanjem lica ili limfnih čvorova, povećanjem broja eozinofila (vrsta bijelih krvnih stanica), učincima na jetru, bubrege ili pluća]
English: These patients received darunavir/ritonavir 800/100 mg once daily in combination with other antiretroviral agents.
Croatian: Ti su bolesnici primali darunavir/ritonavir u dozi od 800/100 mg jedanput na dan u kombinaciji s drugim antiretrovirusnim lijekovima.
English: Thirteen percent of the dose was recovered in the urine as three putative metabolites.
Croatian: Trinaest posto doze pronađeno je u mokraći u obliku tri putativna metabolita.
English: Symtuza, therefore, must not be combined with medicinal products that are highly dependent on CYP3A for clearance and for which increased systemic exposure is associated with serious and/or life-threatening events (narrow therapeutic index) (see section 4.3 or table below).
Croatian: Symtuza se stoga ne smije kombinirati s lijekovima čiji klirens uvelike ovisi o CYP3A i za koje je povećana sistemska izloženost povezana s ozbiljnim i/ili po život opasnim događajima (uzak terapijski indeks) (vidjeti dio 4.3 ili tablicu u nastavku).
English: If overdose occurs the patient must be monitored for evidence of toxicity (see section 4.8).
Croatian: Ako dođe do predoziranja, bolesnika treba nadzirati kako bi se uočili mogući znakovi toksičnosti (vidjeti dio 4.8).
English: Ex vivo rabbit studies and in vivo dog studies suggest that cobicistat has a low potential for QT prolongation, and may slightly prolong the PR interval and decrease left ventricular function at mean concentrations at least 10-fold higher than the human exposure at the recommended 150 mg daily dose.
Croatian: Ispitivanja na kunićima ex vivo i ispitivanja na psima in vivo ukazuju na to da kobicistat ima nizak potencijal da uzrokuje produljenje QT intervala te da može malo produljiti PR interval i smanjiti funkciju lijeve klijetke pri srednjim vrijednostima koncentracija najmanje 10 puta većima od izloženosti u ljudi pri preporučenoj dnevnoj dozi od 150 mg.
English: The main adverse reactions reported are haematological disorders (anaemia, neutropenia) and metabolic disorders (hyperlactataemia, hyperlipasaemia).
Croatian: Glavne prijavljene nuspojave su hematološki poremećaji (anemija, neutropenija) i metabolički poremećaji (hiperlaktatemija, hiperlipazemija).
English: People taking Symtuza may develop a skin rash.
Croatian: Kod ljudi koji uzimaju lijek Symtuza može se razviti kožni osip.
English: Symtuza might increase sugar levels in the blood.
Croatian: Symtuza može povisiti razine šećera u krvi.
English: It is recommended that women with HIV do not breast-feed their infants because of the possibility of the baby becoming infected with HIV through breast milk and because the medicine may affect the baby.
Croatian: Preporučeno je da žene s HIV-om ne doje dojenče zbog mogućnosti prijenosa HIV-a na dijete putem majčina mlijeka te zbog mogućih učinaka lijeka na dijete.
English: Tenofovir has a median plasma half-life of approximately 32 hours.
Croatian: Medijan poluvijeka tenofovira u plazmi iznosi približno 32 sata.
English: Cobicistat has no detectable antiviral activity against HIV-1 and does not antagonise the antiviral effect of darunavir, emtricitabine, or tenofovir.
Croatian: Kobicistat ne pokazuje mjerljivu antivirusnu aktivnost protiv virusa HIV-1 i ne antagonizira antivirusni učinak darunavira, emtricitabina ni tenofovira.
English: Darunavir is approximately 95% bound to plasma protein.
Croatian: Približno 95% darunavira vezuje se za proteine u plazmi.
English: Some side effects are typical for anti-HIV medicines similar to Symtuza.
Croatian: Neke su nuspojave tipične za lijekove protiv HIV-a koji su slični lijeku Symtuza.
English: Based on this limited experience, the safety profile of emtricitabine/tenofovir alafenamide in patients with HIV/HBV co-infection appears to be similar to that in patients with HIV-1 monoinfection (see section 4.4).
Croatian: S obzirom na to ograničeno iskustvo, čini se da je sigurnosni profil emtricitabina/tenofoviralafenamida u bolesnika istodobno zaraženih HIV-om i HBV-om sličan onome u bolesnika koji su zaraženi samo virusom HIV-1 (vidjeti dio 4.4).
English: In HIV infected patients treated with CART, immune reactivation syndrome has been reported.
Croatian: U bolesnika zaraženih HIV-om liječenih KART-om prijavljeni su slučajevi sindroma imunološke reaktivacije.
English: ALPHA ADRENORECEPTOR ANTAGONISTS Alfusozin
Croatian: ANTAGONISTI ALFA-ADRENORECEPTORA Alfuzozin
English: Systemic dexamethasone should be used with caution when combined with Symtuza.
Croatian: Sistemski deksametazon treba koristiti uz oprez kada se kombinira s lijekom Symtuza.
English: The effect of severe hepatic impairment on the pharmacokinetics of darunavir has not been studied (see sections 4.2, 4.3 and 4.4).
Croatian: Učinak teškog oštećenja jetrene funkcije na farmakokinetiku darunavira nije ispitivan (vidjeti dijelove 4.2, 4.3 i 4.4).
English: Rash was mostly mild to moderate, often occurring within the first four weeks of treatment and resolving with continued dosing (see section 4.4).
Croatian: Osip je uglavnom bio blage do umjerene težine, a često se javljao unutar prva četiri tjedna liječenja te se povukao s nastavkom primjene (vidjeti dio 4.4).
English: If concomitant use of Symtuza with sildenafil, vardenafil or tadalafil is indicated, sildenafil at a single dose not exceeding 25 mg in 48 hours, vardenafil at a single dose not exceeding 2.5 mg in 72 hours or tadalafil at a single dose not exceeding 10 mg in 72 hours is recommended.
Croatian: Ako je indicirana istodobna primjena lijeka Symtuza sa sildenafilom, vardenafilom ili tadalafilom, preporučuju se sljedeće doze: jednokratna doza sildenafila koja ne prelazi 25 mg u 48 sati, jednokratna doza vardenafila koja ne prelazi 2,5 mg u 72 sata ili jednokratna doza tadalafila koja ne prelazi 10 mg u 72 sata.
English: In case of concomitant antiviral therapy for hepatitis C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
Croatian: U slučaju istodobne primjene antivirusne terapije za liječenje hepatitisa C, molimo također pogledajte odgovarajući sažetak opisa svojstava lijeka za te lijekove.
English: Latina Italy
Croatian: Latina Italija
English: With ritonavir-boosted darunavir, a small decrease in methadone plasma concentrations was observed.
Croatian: Kod primjene darunavira pojačanog ritonavirom primijećeno je malo sniženje plazmatske koncentracije metadona.
English: Changes in measures of bone mineral density
Croatian: Promjene u mjerama mineralne gustoće kostiju
English: A potential risk of nephrotoxicity resulting from chronic exposure to low levels of tenofovir due to dosing with tenofovir alafenamide cannot be excluded (see section 5.3).
Croatian: Ne može se isključiti mogući rizik od nefrotoksičnosti kao posljedice kronične izloženosti niskim razinama tenofovira zbog primjene tenofoviralafenamida (vidjeti dio 5.3).
English: DRV = darunavir; FTC = emtricitabine; PDVF = protocol-defined virologic failure; PI = protease inhibitor; RAM = resistanceassociated mutation; TDF = tenofovir disoproxil fumarate; TAF = tenofovir alafenamide
Croatian: DRV = darunavir; FTC = emtricitabin; PDVF (protocol-defined virologic failure), protokolom definiran virološki neuspjeh; TDF = tenofovirdizoproksilfumarat; TAF = tenofoviralafenamid
English: 95-1,110), and median CD4+ % was 23% (range: 7-45%).
Croatian: 3 (raspon: 95 - 1110), a medijan % CD4+ 23% (raspon: 7 - 45%).
English: It is recommended that the lowest possible dose of digoxin should initially be given to patients on Symtuza.
Croatian: Preporučuje se da se bolesnicima koji uzimaju lijek Symtuza na početku daje najniža moguća doza digoksina.
English: simvastatin, lovastatin and lomitapide (see section 4.5) - dabigatran, ticagrelor
Croatian: lovastatin i lomitapid (vidjeti dio 4.5) - dabigatran, tikagrelor
English: In rats, ossification changes in the spinal column and sternebrae of fetuses occurred at a dose that produced significant maternal toxicity.
Croatian: U štakora su primijećene osifikacijske promjene na kralježnici i segmentima prsne kosti fetusa pri dozi koja je uzrokovala značajnu toksičnost za majku.
English: Frequency categories are defined as follows: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000) and not known (frequency cannot be estimated from the available data)
Croatian: Nuspojave su navedene prema organskim sustavima i kategorijama učestalosti u Tablici 2. Kategorije učestalosti definirane su kako slijedi: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000) i nepoznato (učestalost se ne može procijeniti iz dostupnih podataka).
English: Any child exposed in utero to nucleoside and nucleotide analogues, even HIV negative children, should have clinical and laboratory follow-up and should be fully investigated for possible mitochondrial dysfunction in case of relevant signs or symptoms.
Croatian: Svako dijete izloženo nukleozidnim i nukleotidnim analozima in utero, čak i HIV-negativnu djecu, treba klinički i laboratorijski pratiti te u slučaju pojave relevantnih znakova ili simptoma pažljivo istražiti mogućnost mitohondrijske disfunkcije.
English: Concomitant use of PDE-5 inhibitors for the treatment of erectile dysfunction with Symtuza should be done with caution.
Croatian: Istodobnu primjenu inhibitora PDE5 za liječenje erektilne disfunkcije i lijeka Symtuza treba provoditi uz oprez.
English: Emtricitabine did not inhibit the glucuronidation reaction of a non-specific UGT substrate in vitro.
Croatian: Emtricitabin nije inhibirao reakciju glukuronidacije nespecifičnog supstrata UGT-a in vitro.
English: Amitriptyline Desipramine Imipramine Nortriptyline Trazodone
Croatian: Amitriptilin Desipramin Imipramin Nortriptilin Trazodon
English: • darunavir, an anti-HIV medicine known as a protease inhibitor
Croatian: • darunavir, lijek za HIV poznat kao inhibitor proteaze
English: Co-administration of Symtuza and medicinal products primarily metabolised by CYP3A may result in increased systemic exposure to such medicinal products, which could increase or prolong their therapeutic effect and adverse reactions.
Croatian: Istodobna primjena lijeka Symtuza i lijekova koji se primarno metaboliziraju pomoću CYP3A može dovesti do povećanja sistemske izloženosti takvim lijekovima, što može povećati ili produljiti njihov terapijski učinak i nuspojave.
English: Mean systemic emtricitabine exposure was higher in patients with severe renal impairment (eGFRCG < 30 mL/min) (33.7 mcg•h/mL) than in subjects with normal renal function (11.8 mcg•h/mL).
Croatian: Srednja vrijednost sistemske izloženosti emtricitabinu bila je viša u bolesnika s teškim oštećenjem bubrežne funkcije (eGFRCG < 30 ml/min) (33,7 µg•h/ml) nego u ispitanika s normalnom bubrežnom funkcijom (11,8 µg•h/ml).
English: This effect on serum creatinine, leading to a decrease in the estimated creatinine clearance, should be taken into consideration when Symtuza is administered to patients, in whom the estimated creatinine clearance is used to guide aspects of their clinical management,including adjusting doses of co-administered medicinal products.
Croatian: Ovaj učinak na kreatinin u serumu, koji dovodi do smanjenja procijenjenog klirensa kreatinina, treba uzeti u obzir kada se Symtuza primjenjuje u bolesnika u kojih se odluke o kliničkom liječenju, uključujući prilagodbu doza istodobno primijenjenih lijekova donose na temelju procijenjenog klirensa kreatinina.
English: Darunavir is primarily metabolised and eliminated by the liver.
Croatian: Darunavir se prvenstveno metabolizira i eliminira putem jetre.
English: The below list of examples of drug drug interactions is not comprehensive and therefore the label of each drug that is co-administered with Symtuza should be consulted for information related to the route of metabolism, interaction pathways, potential risks, and specific actions to be taken with regards to co-administration.
Croatian: Donja tablica primjera interakcija s drugim lijekovima nije sveobuhvatna, stoga je potrebno proučiti informacije o lijeku za svaki lijek koji se primjenjuje zajedno s lijekom Symtuza, kako bi se informirali o metabolizmu lijeka, putovima interakcije, potencijalnim rizicima i specifičnim aktivnostima koje treba poduzeti s obzirom na istodobnu primjenu.
English: Symtuza should not be initiated in patients with eGFRCG < 30 mL/min, as there are no data available regarding the use of Symtuza in this population (see sections 5.1 and 5.2).
Croatian: Liječenje lijekom Symtuza ne smije se započeti u bolesnika s vrijednošću eGFRCG < 30 ml/min, jer nema dostupnih podataka o primjeni lijeka Symtuza u ovoj populaciji (vidjeti dijelove 5.1 i 5.2).
English: Lurasidone Pimozide Quetiapine Sertindole
Croatian: Lurazidon Pimozid Kvetiapin Sertindol
English: 6 cells/L (range 38 - 1,456 x 10
Croatian: 6 stanica/L (raspon 38 - 1456 x 10
English: If you have kidney or liver problems see section ‘Do not combine
Croatian: Ako imate problema s bubrezima i/ili jetrom pogledajte dio
English: There are other uses for sildenafil.
Croatian: Sildenafil se koristi i za druge svrhe.
English: The concomitant use with Symtuza may require to lower the dose of alfentanil and requires monitoring for risks of prolonged or delayed respiratory depression.
Croatian: Istodobna primjena s lijekom Symtuza može zahtijevati smanjenje doze alfentanila te zahtijeva praćenje zbog rizika od produljene ili odgođene depresije disanja.
English: Treatment with darunavir/cobicistat (two of the components of Symtuza) during pregnancy results in low darunavir exposure (see section 5.2), which may be associated with an increased risk of treatment failure and an increased risk of HIV transmission to the child.
Croatian: Liječenje darunavirom/kobicistatom (dvije komponente lijeka Symtuza) tijekom trudnoće rezultira niskom izloženošću darunaviru (vidjeti dio 5.2), što može biti povezano s povećanim rizikom neuspjeha liječenja i povećanim rizikom prijenosa HIV-a na dijete.
English: There is an increased potential for sildenafil-associated adverse events (including visual disturbances, hypotension, prolonged erection and syncope).
Croatian: Povećana je mogućnost razvoja nuspojava povezanih sa sildenafilom (uključujući poremećaje vida, hipotenziju, produljenu erekciju i sinkopu).
English: No pharmacokinetic data are available for emtricitabine and tenofovir alafenamide during pregnancy.
Croatian: Nisu dostupni farmakokinetički podaci za emtricitabin i tenofoviralafenamid tijekom trudnoće.
English: Discontinuation of Symtuza therapy in patients co-infected with HIV and HBV may be associated with severe acute exacerbations of hepatitis.
Croatian: Prekid terapije lijekom Symtuza u bolesnika istodobno zaraženih HIV-om i HBV-om može biti povezan s teškim akutnim egzacerbacijama hepatitisa.
English: Symtuza may decrease boceprevir plasma concentrations.
Croatian: Symtuza može sniziti plazmatske koncentracije boceprevira.
English: C]-radioactivity showed a time-dependent profile with tenofovir alafenamide as the most abundant species in the initial few hours and uric acid in the remaining period.
Croatian: C]-radioaktivnost u plazmi pokazala je profil ovisan o vremenu, pri čemu je najzastupljeniji spoj tijekom prvih nekoliko sati bio tenofoviralafenamid, a tijekom preostalog razdoblja mokraćna kiselina.
English: White, high density polyethylene (HDPE) bottle with a silica gel desiccant (contained in a separate sachet or canister) fitted with polypropylene (PP) child resistant closure with induction seal.
Croatian: Bijela boca od polietilena visoke gustoće (HDPE) sa silikagelom kao sredstvom za sušenje (u posebnoj vrećici ili spremniku), zatvorena zaštitnom folijom i polipropilenskim (PP) sigurnosnim zatvaračem za djecu.
English: Human experience of acute overdose with Symtuza is limited.
Croatian: Iskustvo s akutnim predoziranjem lijekom Symtuza u ljudi je ograničeno.
English: There have been reports of mitochondrial dysfunction in HIV negative infants exposed in utero and/or postnatally to nucleoside analogues.
Croatian: Prijavljeni su slučajevi mitohondrijske disfunkcije u HIV-negativne novorođenčadi koja je bila izložena nukleozidnim analozima in utero i/ili nakon rođenja.
English: Patients co-infected with HIV and hepatitis B or C virus
Croatian: Bolesnici istodobno zaraženi HIV-om i virusom hepatitisa B ili C
English: HMG CO-A REDUCTASE INHIBITORS Atorvastatin
Croatian: INHIBITORI HMG-CoA REDUKTAZA Atorvastatin
English: Symtuza reduces HIV-1 in your body and this will improve your immune system (your body's natural defences) and reduce the risk of developing illnesses linked to HIV infection but Symtuza is not a cure for HIV infection.
Croatian: Vaš imunološki sustav (prirodni obrambeni mehanizam Vašeg tijela) i smanjiti rizik od razvoja bolesti povezanih s HIV infekcijom, ali Symtuza neće izliječiti HIV infekciju.
English: Patients were allowed in the study if they had previous failure on any non-darunavir ARV regimen.
Croatian: Bolesnicima je bio dopušten ulazak u ispitivanje ako su prethodno imali nesupjeh na bilo kojem antiretrovirusnom režimu koji nije sadržavao darunavir.
English: Co-administration with the following medicinal products due to the potential for loss of therapeutic effect (see section 4.5): - carbamazepine, phenobarbital, phenytoin - rifampicin
Croatian: Istodobna primjena sa sljedećim lijekovima zbog mogućeg gubitka terapijskog učinka (vidjeti dio 4.5): - karbamazepin, fenobarbital, fenitoin - rifampicin
English: Decrease estimated creatinine clearance
Croatian: Smanjenje procijenjenog klirensa kreatinina