FrancophonIA/ELRC3.0 huggingface dataset:
English: Sertraline did not produce either the stimulation and anxiety associated with d-amphetamine or the sedation and psychomotor impairment associated with alprazolam.
Slovenian: Sertralin ni povzročil niti stimulacije in anksioznosti, ki spremljata D-amfetamin, niti sedacije in psihomotoričnega zavrtja, ki spremljata alprazolam.
English: Major Depressive Disorder
Slovenian: Hude depresivne motnje
English: After marketing sertraline, the following side effects have been reported:
Slovenian: Po prihodu sertralina na tržišče so bili opisani naslednji neželeni učinki:
English: The dose should be taken immediately after dilution.
Slovenian: Odmerek morate vzeti takoj po razredčenju.
English: Furthermore, if any of the symptoms listed above appear or worsen when a patient under 18 is taking Zoloft, you should inform your doctor.
Slovenian: Če se pojavi ali poslabša katerikoli od zgoraj navedenih simptomov pri bolnikih, ki so mlajši od 18 let in jemljejo zdravilo Zoloft, morate obvestiti svojega zdravnika.
English: Severe adverse reactions have been reported in patients who have recently been discontinued from an MAOI and started on sertraline, or have recently had sertraline therapy discontinued prior to initiation of an MAOI.
Slovenian: Opisani so bili hudi neželeni učinki pri bolnikih, ki so pred kratkim nehali dobivati zaviralec MAO in so začeli zdravljenje s sertralinom, ali so pred kratkim nehali dobivati sertralin in jim je bil uveden zaviralec MAO.
English: In addition, a trend toward greater improvement in the sertraline group than the placebo group was also observed on the CGI Severity scale (p=0.089).
Slovenian: Poleg tega so v skupini s sertralinom v primerjavi s skupino s placebom opazili tudi trend k večjemu izboljšanju na lestvici CGI-S (CGI Severity; p = 0,089).
English: While the mechanism of this interaction is unknown, due to the narrow therapeutic index of pimozide, concomitant administration of sertraline and pimozide is contraindicated (see section 4.3).
Slovenian: Mehanizem tega medsebojnega delovanja ni znan, a zaradi ozkega terapevtskega indeksa pimozida je sočasna uporaba sertralina in pimozida kontraindicirana (glejte poglavje 4.3).
English: For CY-BOCs the mean baseline and change from baseline scores for the placebo group was 22.25 ± 6.15 and -3.4 ± 0.82, respectively, while for the sertraline group, the mean baseline and change from baseline scores were 23.36 ± 4.56 and -6.8 ± 0.87, respectively.
Slovenian: V skupini s placebom je bil izhodiščni seštevek CY-BOC 22,25 ± 6,15 in sprememba od izhodišča -3,4 ± 0,82, v skupini s sertralinom pa je bil izhodiščni seštevek CY-BOC 23,36 ± 4,56 in sprememba od izhodišča -6,8 ± 0,87.
English: [See Annex I - To be completed nationally] Sertraline
Slovenian: [Glejte dodatek I - izpolni država posebej] sertralin
English: OCD and Panic disorders are illnesses linked to anxiety with symptoms like being constantly troubled by persistent ideas (obsessions) that make you carry out repetitive rituals (compulsions).
Slovenian: Obsesivno kompulzivna motnja (OKM) in panična motnja sta bolezni, ki sta povezani s tesnobnostjo, s simptomi kot so trdovratne misli in prepričanja (obsesije), ki vas silijo v ponavljajoče se rituale (kompulzije).
English: Two previous additional open label extension studies (that were not submitted within the context of this dossier) showed serious AEs, some of which were possibly related to study drug, including severe aggressive reactions, nervousness and paranoid reactions, two severe grand mal seizures,
Slovenian: Dve prejšnji, dodatni neslepi razširjeni študiji, (ki nista bili predloženi v okviru te dokumentacije), sta izkazali resne neželene učinke, pri čemer so bili nekateri verjetno povezani s proučevanim zdravilom in so vključevali hude agresivne reakcije, živčnost in paranoidne reakcije, dva težka generalizirana epileptična napada ter poslabšanje samomorilnega in nasilnega razmišljanja.
English: Clinical pharmacology studies have shown that sertraline has no effect on psychomotor performance.
Slovenian: Klinične farmakološke študije so pokazale, da sertralin ne vpliva na psihomotorično zmogljivost.
English: Panic disorder, with or without agoraphobia.
Slovenian: Panične motnje z agorafobijo ali brez nje.
English: Sertraline concentrate for oral solution must be diluted before use (see section 6.6).
Slovenian: Koncentrat za peroralno raztopino sertralina je treba pred uporabo razredčiti (glejte poglavje 6.6).
English: Moreover, with respect to safety, no data was submitted on endocrine parameters, effects on cognition and other maturation parameters.
Slovenian: Nadalje niso bili glede varnosti predloženi nobeni podatki o učinkih na endokrine dejavnike, učinkih na kognitivno dojemanje ter na druge dejavnike razvoja.
English: • If you experience agitation, confusion, diarrhoea, high temperature and blood pressure, excessive sweating and rapid heartbeat.
Slovenian: • Če se vam pojavijo vznemirjenost, zmedenost, driska, visoka telesna temperatura in visok krvni tlak, čezmerno potenje in hitro bitje srca.
English: • Medicines called monoamine oxidase inhibitors (MAOIs), like moclobemid (to treat depression) and selegiline (to treat Parkinson's disease) and the antibiotic linezolid.
Slovenian: • Skupina zdravil, imenovanih zaviralci monoaminooksidaze (MAOI), kot moklobemid (za zdravljenje depresije), selegilin (za zdravljenje Parkinsonove bolezni) in antibiotik linezolid.
English: In studies of patients with mild to moderate renal impairment (creatinine clearance 30-60 ml/min) or moderate to severe renal impairment (creatinine clearance 10-29 ml/min), multiple-dose pharmacokinetic parameters (AUC0-24 or Cmax) were not significantly different compared with controls.
Slovenian: V študijah bolnikov z blago do zmerno okvaro ledvic (očistek kreatinina 30-60 ml/min [0,5-1 ml/sek]) ali zmerno do hudo okvaro ledvic (očistek kreatinina 10-29 ml/min [0,167-0,483 ml/sek]) se farmakokinetični parametri (AUC0-24 oz. Cmax) pri uporabi več odmerkov niso pomembno razlikovali od tistih pri kontrolnih osebah.
English: Generally neglible to undetectable levels were found in infant serum, with one exception of an infant with serum levels about 50% of the maternal level (but without a noticeable health effect in this infant).
Slovenian: Koncentracija v dojenčkovem serumu je bila na splošno zanemarljiva do nezaznavna; izjema je bil dojenček, ki je imel koncentracijo v serumu okrog 50 % materine koncentracije, vendar pri tem dojenčku ni bilo opaznih učinkov na njegovo zdravstveno stanje.
English: Children and adolescents with obsessive compulsive disorder Age 13-17 years: Initially 50 mg once daily.
Slovenian: Otroci in mladostniki z obsesivno-kompulzivno motnjo Starost 13 - 17 let: začetni odmerek - 50 mg enkrat na dan.
English: Clinical relevant interactions may occur with other CYP 2D6 substrates with a narrow therapeutic index like class 1C antiarrhythmics such as propafenone and flecainide, TCAs and typical antipsychotics, especially at higher sertraline dose levels.
Slovenian: Klinično pomembna medsebojna delovanja se lahko pojavijo z drugimi substrati CYP 2D6 z ozkim terapevtskim indeksom, npr. antiaritmiki iz skupine 1C, kakršna sta propafenon in flekainid, tricikličnimi antidepresivi in tipičnimi antipsihotiki, zlasti med uporabo večjih odmerkov sertralina.
English: The results of the short-term studies show that 3 of the 5 placebo controlled studies demonstrated statistically significant results and that these results are supported by responders analysis that indicate a higher proportion of responders in the active arms compared to placebo.
Slovenian: Rezultati kratkoročnih študij kažejo, da tri od petih s placebom kontroliranih študij dokazujejo statistično pomembne rezultate ter da te rezultate podpira analiza bolnikov, ki so se odzvali na zdravljenje, kar nakazuje višji delež odzivnih bolnikov med tistimi, ki so prejemali učinkovino, kot pri tistih, ki so dobivali placebo.
English: The CHMP implemented the following text in section 4.2 of the SPC, to indicate that the need for continued treatment should be regularly evaluated:
Slovenian: CHMP je v poglavje 4.2 povzetka glavnih značilnosti zdravila vključil naslednje besedilo, ki nakazuje, da je treba potrebo po nadaljevanju zdravljenja redno ocenjevati.
English: Accordingly, prothrombin time should be carefully monitored when sertraline therapy is initiated or stopped.
Slovenian: Glede na to je treba protrombinski čas po začetku ali koncu zdravljenja s sertralinom skrbno nadzorovati.
English: When stopping treatment with sertraline the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions (see sections 4.4 and 4.8).
Slovenian: Pri ukinitvi zdravljenja s sertralinom je potrebno postopno zmanjševati odmerek najmanj v obdobju enega do dveh tednov, da tako zmanjšamo tveganje za pojav odtegnitvenih reakcij (glejte poglavji 4.4 in 4.8).
English: • Products containing the amino acid tryptophan.
Slovenian: • Izdelke, ki vsebujejo aminokislino triptofan.
English: • Other medicines to treat depression (such as amitriptyline, nortriptyline).
Slovenian: • Druga zdravila za zdravljenje depresije (npr. amitriptilin, nortriptilin)
English: Co-administration with sertraline is not recommended
Slovenian: Sočasna uporaba s sertralinom ni priporočljiva
English: • Do not use Zoloft together with disulfiram.
Slovenian: • Ne jemljite zdravila Zoloft sočasno z disulfiramom.
English: Sertraline does not act as an inhibitor of CYP 3A4, CYP 2C9, CYP 2C19, and CYP 1A2 to a clinically significant degree.
Slovenian: Sertralin nima klinično pomembnega učinka kot zaviralec CYP 3A4, CYP 2C9, CYP 2C19 in CYP 1A2.
English: Marketing Authorisation Holder (Invented) name
Slovenian: Imetnik dovoljenja za promet Izmišljeno ime
English: Sertraline should be discontinued in any patient entering a manic phase.
Slovenian: Uporabo sertralina morate prekiniti, če bolnik prehaja v manično fazo.
English: Section 4.1 - Indications: Panic disorder with or without agoraphobia disorder
Slovenian: Poglavje 4.1 - Indikacije: Panična motnja z agorafobično motnjo ali brez nje
English: Triptans
Slovenian: Triptani
English: In the two positive general population trials, the male and female sertraline vs. placebo responder rates were similar (females: 57.2% vs 34.5%; males: 53.9% vs 38.2%).
Slovenian: V dveh pozitivnih preskušanjih, izvedenih na splošni populaciji, je bil odziv moških in žensk, zdravljenih s sertralinom v primerjavi s placebom, podoben (ženske: 57,2 % proti 34,5 %; moški: 53,9 % proti 38,2 %).
English: Schizophrenia Psychotic symptoms might become aggravated in schizophrenic patients.
Slovenian: Shizofrenija Bolnikom s shizofrenijo se lahko psihotični simptomi poslabšajo.
English: Table 1 displays adverse reactions observed from postmarketing experience (frequency not known) and placebo-controlled clinical trials (comprising a total of 2542 patients on sertraline and 2145 on placebo) in depression, OCD, panic disorder, PTSD and social anxiety disorder.
Slovenian: Preglednica 1 prikazuje neželene učinke, zabeležene med izkušnjami iz obdobja trženja (pogostnost ni znana) in v kliničnih preskušanjih, nadzorovanih s placebom (skupaj so zajela 2542 bolnikov s sertralinom in 2145 s placebom), pri depresiji, OKM, panični motnji, PTSM in socialni anksiozni motnji.
English: Food does not significantly change the bioavailability of sertraline tablets.
Slovenian: Hrana ne povzroči pomembne spremembe biološke uporabnosti tablet sertralina.
English: As the capsule contains the excipient lactose (see section 6.1), patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Kapsule kot pomožno snov vsebujejo laktozo (glejte poglavje 6.1), zato bolniki z redkimi prirojenimi motnjami, kot so galaktozna intoleranca, laponska oblika zmanjšane aktivnosti laktaze ali malabsorpcija laktoze, ne smejo jemati tega zdravila.
English: Sertraline exhibits dose proportional pharmacokinetics in the range of 50 to 200 mg.
Slovenian: Sertralin ima v območju od 50 do 200 mg odmerka sorazmerno farmakokinetiko.
English: Anaphylactoid Reaction, Allergic Reaction, Allergy
Slovenian: Bolezni imunskega sistema anafilaktoidna reakcija, alergijska reakcija, alergija
English: In accord with its selective inhibition of 5-HT uptake, sertraline does not enhance catecholaminergic activity.
Slovenian: Sertralin skladno s svojim selektivnim zavrtjem privzema 5-HT ne zvečuje kateholaminergičnega delovanja.
English: Do not mix the concentrate with anything other than the liquids listed.
Slovenian: Koncentrata ne smete redčiti z ničimer drugim kot z naštetimi tekočinami.
English: Depression and OCD Sertraline treatment should be started at a dose of 50 mg/day.
Slovenian: Depresija in OKM Sertralin je treba uporabiti v odmerku 50 mg/dan.
English: Switching from Selective Serotonin Reuptake Inhibitors (SSRIs), antidepressants or antiobsessional drugs
Slovenian: Prehod s selektivnih zaviralcev ponovnega privzema serotonina (SSRI), antidepresivov ali antiobsesivnih zdravil
English: The active compound of Zoloft and associated names is sertraline, a selective serotonin reuptake inhibitor (SSRI).
Slovenian: Učinkovina zdravila Zoloft in z njim povezanih imen je sertralin, selektivni zaviralec ponovnega privzema serotonina (SSRI).
English: Depression, OCD, Panic Disorder, Social Anxiety Disorder and PTSD Patients not responding to a 50 mg dose may benefit from dose increases.
Slovenian: Depresija, OKM in panična motnja ter PTSM in socialna anksiozna motnja Bolnikom, ki se ne odzovejo na odmerek 50 mg, lahko koristi zvečanje odmerka.
English: In previous applications, the MAH had submitted data from a placebo-controlled withdrawal study (relapse prevention study) in which responders to 1 year open label treatment were randomised to treatment with sertraline or placebo for a duration of 28 weeks and the results from that study were considered.
Slovenian: V prejšnjih vlogah je imetnik dovoljenja za promet predložil podatke iz s placebom kontrolirane ukinitvene študije (študije preprečevanja ponovitev), v kateri so bili odzivni bolniki po enoletnem neslepem zdravljenju naključno izbrani za 28-tedensko zdravljenje s sertralinom ali placebom, upoštevani pa so bili rezultati te študije.
English: Sertraline and N-desmethylsertraline are both extensively metabolized in man and the resultant metabolites excreted in faeces and urine in equal amounts.
Slovenian: Pri človeku se sertralin in Ndezmetilsertralin oba izdatno presnavljata; nastali presnovki se v enakih količinah izločijo v blatu in urinu.
English: 6.6 Special precautions for disposal and other handling No special requirements
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom Ni posebnih ukrepov.
English: Serious liver events (including hepatitis, jaundice and liver failure)
Slovenian: Resni jetrni učinki (vključno s hepatitisom, zlatenico in odpovedjo jeter)
English: Reproduction toxicity studies in animals showed no evidence of teratogenicity or adverse effects on male fertility.
Slovenian: Študije vpliva na sposobnost razmnoževanja pri živalih niso pokazale teratogenega delovanja ali neželenih učinkov na plodnost samcev.
English: Depending on hepatic function, this effect may still be present for as long as two weeks after the last dose of disulfiram, although one week is the more typical duration of action with standard doses.
Slovenian: Odvisno od delovanja jeter je učinek disulfirama lahko prisoten še dva tedna po zadnjem odmerku, čeprav je običajno obdobje učinkovanja priporočenega odmerka en teden.
English: Capsules, hard
Slovenian: Trde kapsule
English: In clinical trials, among patients treated with sertraline, the incidence of reported withdrawal reactions was 23% in those discontinuing sertraline compared to 12% in those who continued to receive sertraline treatment.
Slovenian: V kliničnih preskušanjih je bila pogostnost odtegnitvenih reakcij med bolniki, ki so prenehali dobivati sertralin 23 %, med tistimi, ki so ga dobivali še naprej pa 12 %.
English: Co-administration of sertraline 200 mg daily with warfarin resulted in a small but statistically significant increase in prothrombin time, which may in some rare cases unbalance the INR value.
Slovenian: Sočasna uporaba 200 mg sertralina na dan z varfarinom je malo, a statistično pomembno podaljšala protrombinski čas, kar lahko v nekaterih redkih primerih povzroči spremembo INR.
English: Published data concerning sertraline levels in breast milk show that small quantities of sertraline and its metabolite N-desmethylsertraline are excreted in milk.
Slovenian: Objavljeni podatki o koncentraciji sertralina v materinem mleku kažejo, da se v mleko izloča majhna količina sertralina in njegovega presnovka N-dezmetilsertralina.
English: The % of responders (defined as those patients that did not relapse) for sertraline and placebo arms were 83.4% and 60.8%, respectively.
Slovenian: Odstotek odzivnih bolnikov (ti so bili opredeljeni kot bolniki, pri katerih se ni pojavil relaps) je bil v kraku s sertralinom 83,4 % in v kraku s placebom 60,8 %.
English: To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease, or epilepsy.
Slovenian: Vsebnost alkohola je treba upoštevati pri nosečnicah in doječih materah, otrocih in zelo ogroženih skupinah, npr. bolnikih z obolenjem jeter ali epilepsijo.
English: • Medicines to treat mania and depression (lithium).
Slovenian: • Zdravila za zdravljenje manije in depresije (litij)
English: Women of childbearing potential should employ an adequate method of contraception if taking sertraline.
Slovenian: Ženske v rodni dobi bi morale uporabljati primerno kontracepcijsko zaščito med jemanjem sertralina.
English: In patients with diabetes, treatment with an SSRI may alter glycaemic control, possibly due to improvement of depressive symptoms.
Slovenian: Zdravljenje s SSRI lahko pri sladkornih bolnikih vpliva na stanje glikemije, morda zaradi izboljšanja depresivnih simptomov.
English: Sertraline is not recommended in pregnancy, unless the clinical condition of the woman is such that the benefit of the treatment is expected to outweigh the potential risk.
Slovenian: Sertralina med nosečnostjo ni priporočljivo uporabljati, razen če je klinično stanje ženske takšno, da pričakovane koristi zdravljenja odtehtajo možno tveganje.
English: These undesirable effects are dose dependent and are often transient in nature with continued treatment.
Slovenian: Ti neželeni učinki so odvisni od odmerka in se med nadaljevanjem zdravljenja pogosto izkažejo za prehodne.
English: Concomitant treatment with irreversible monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of serotonin syndrome with symptoms such as agitation, tremor and hyperthermia.
Slovenian: Sočasno zdravljenje z ireverzibilnimi zaviralci monoaminooksidaze (zaviralci MAO) je kontraindicirano zaradi tveganja serotoninskega sindroma s simptomi, kot so agitiranost, tremor in hipertermija.
English: There is evidence that sertraline is excreted in human breast milk.
Slovenian: Podatki kažejo, da se sertralin pri človeku izloča v materino mleko.
English: Panic Disorder, PTSD, and Social Anxiety Disorder Therapy should be initiated at 25 mg/day.
Slovenian: Panična motnja, PTSM in socialna anksiozna motnja Zdravljenje je treba začeti s 25 mg/dan.
English: Sertraline concentrate for oral solution contains 20 mg/ml of sertraline.
Slovenian: Sertralin koncentrat za peroralno raztopino vsebuje 20 mg sertralina/ml.
English: Paediatric patients with OCD
Slovenian: Pediatrični bolniki z OKM
English: What Zoloft is and what it is used for.
Slovenian: Kaj je zdravilo Zoloft in za kaj ga uporabljamo 2.
English: The risk of withdrawal symptoms depends on the length of treatment, dosage, and the rate at which the dose is reduced.
Slovenian: Tveganje za odtegnitveno reakcijo je odvisno od dolžine zdravljenja, odmerka in hitrosti zmanjševanja odmerka.
English: • Medicines to treat schizophrenia and other mental disorders (such as perphenazine,
Slovenian: • Zdravila za zdravljenje shizofrenije in drugih duševnih motenj (npr. perfenazin,
English: In patients with liver damage, the half life of sertraline is prolonged and AUC is increased three fold (see sections 4.2 and 4.4).
Slovenian: Pri bolnikih z okvaro jeter je podaljšan razpolovni čas sertralina, AUC pa je približno trikrat večji (glejte poglavje 4.2 in 4.4).
English: A review of the trials included in this dossier indicated that there were two trials that included patients with a bipolar disorder and one with depression accompanied by symptoms of anxiety.
Slovenian: Pregled študij, vključenih v to dokumentacijo, je pokazal, da so bili v dve študiji vključeni bolniki z bipolarno motnjo, v eno študijo pa depresivni bolniki s spremljajočimi znaki anksioznosti.
English: Adolescents and elderly
Slovenian: Mladostniki in odrasli
English: Nausea is the most common undesirable effect.
Slovenian: Najpogostejši neželeni učinek je navzea.
English: In patients with moderate-severe renal impairment, there was no significant accumulation of sertraline.
Slovenian: Okvara ledvic Pri bolnikih z zmerno ali hudo okvaro ledvic ni bilo pomembnega kopičenja sertralina.
English: • Diabetes; your blood glucose levels may be altered due to Zoloft and your diabetes medicines may need to be adjusted.
Slovenian: • Sladkorna bolezen; zaradi jemanja zdravila Zoloft se lahko spremeni nivo glukoze v krvi, zato je potrebno prilagoditi odmerek zdravila za zdravljenje sladkorne bolezni.
English: Induction of emesis is not recommended.
Slovenian: Sprožitev bruhanja ni priporočljiva.
English: The results submitted indicated that only 6 patients relapsed during the withdrawal phase of this study, 6% in placebo and 1% in the sertraline arm.
Slovenian: Predloženi rezultati so pokazali, da je bilo zdravljenje med ukinitvenim obdobjem študije neuspešno pri le 6 bolnikih, pri 6 % oseb, zdravljenih s placebom, in pri 1 % tistih, zdravljenih s sertralinom.
English: If concomitant treatment with sertraline and triptans is clinically warranted, appropriate observation of the patient is advised (see section 4.4).
Slovenian: Če je sočasna uporaba sertralina in triptanov klinično potrebna, je treba bolnika ustrezno nadzorovati (glejte poglavje 4.4).
English: A multiple dose pharmacokinetic study in subjects with mild, stable cirrhosis demonstrated a prolonged elimination half life and approximately threefold greater AUC and Cmax in comparison to normal subjects.
Slovenian: Farmakokinetična študija več odmerkov pri preiskovancih z blago, stabilno cirozo je pokazala, da je razpolovni čas izločanja pri njih podaljšan, AUC in Cmax pa sta približno trikrat večji kot pri zdravih preiskovancih.
English: In general, the CHMP considered the wordings proposed by the MAH to be acceptable.
Slovenian: Na splošno je CHMP menil, da je besedilo, ki ga je predlagal imetnik dovoljenja za promet z zdravilom, sprejemljivo.
English: “Sertraline is indicated for the treatment of major depressive episodes.
Slovenian: „Sertralin je indiciran za zdravljenje hudih depresivnih epizod.
English: However, the generally lower body weights of children compared to those of adults should be taken into consideration when increasing the dose from 50 mg.
Slovenian: Vendar je v splošnem treba pri povečevanju 50-miligramskega odmerka upoštevati nižjo telesno maso otrok v primerjavi z odraslimi.
English: If you have a manic episode, contact your doctor immediately.
Slovenian: Če imate manični napad takoj obvestite svojega zdravnika.
English: In vitro studies indicate that sertraline has little or no potential to inhibit CYP 1A2.
Slovenian: Študije in vitro kažejo, da sertralin zavira CYP 1A2 le malo ali sploh ne.
English: Following treatment with a reversible MAO-inhibitor, a shorter withdrawal period than 14 days may be used before initiation of sertraline treatment.
Slovenian: Po zdravljenju z reverzibilnim zaviralcem MAO je lahko obdobje prekinitve pred uvedbo zdravljenja s sertralinom krajše od 14 dni.