FrancophonIA/ELRC3.0 huggingface dataset:
English: Ask your doctor to explain what can be done to protect you or allow you to have a family.
Estonian: Paluge arstil endale selgitada, mida on võimalik teha teie kaitsmiseks või teil pere loomise võimaldamiseks.
English: Patients who met each of the following criteria:
Estonian: Patsiendid vastavad kõikidele järgmistele kriteeriumidele:
English: If you (or your child) weigh less than 20 kg, the infusion time may be longer.
Estonian: Kui teie (või teie lapse) kehakaal on vähem kui 20 kg, võib infusiooniaeg olla pikem.
English: Estimates based on other analysis
Estonian: Muul analüüsil põhinevad hinnangud
English: Children < 1 year old
Estonian: Lapsed vanuses < 1 aastat
English: *ITT = intention to treat.
Estonian: *ITT (intent to treat) = ravikavatsus.
English: The median age of treated patients (37 males, 24 females) was 12 years old.
Estonian: Ravitud patsientide (37 mees-, 24 naissoost) mediaanvanus oli 12 aastat.
English: The infusion will be given over 2 hours.
Estonian: Infusiooni kestus on 2 tundi.
English: Overall remission (CR + CRp)
Estonian: Üldine remissioon (CR + CRp)
English: 5.2 hours
Estonian: > 5,2 tundi
English: Children weighing < 20 kg
Estonian: Lapsed kehakaaluga < 20 kg
English: However, there are no known clinically significant interactions with other medicinal products or laboratory tests.
Estonian: Samas pole ka teadaolevaid kliiniliselt olulisi koostoimeid teiste ravimitega või laboratoorsete testidega.
English: Your doctor will give you Ivozall once every day for 5 days.
Estonian: Arst manustab teile Ivozalli üks kord ööpäevas 5 päeva jooksul.
English: Your doctor will tell you when you need to be given this medicine.
Estonian: Arst ütleb teile, kui teile on vaja seda ravimit anda.
English: Adverse reactions reported during the post-marketing period are also included in the table under the frequency category “not known” (cannot be estimated from the available data).
Estonian: Kõrvaltoimed, millest on teatatud turustamisjärgsel perioodil, on samuti lisatud tabelisse sageduskategooriaga „teadmata“ (ei saa hinnata olemasolevate andmete alusel).
English: It is important to drink plenty of water to avoid dehydration.
Estonian: Tähtis on juua rohkesti vett, et vältida vedelikuvaeguse teket.
English: No specific antidotal therapy exists.
Estonian: Spetsiifiline antidootravi puudub.
English: (There are no exposure data in rabbits.)
Estonian: (Küülikute kohta süsteemse saadavuse andmed puuduvad.)
English: It is a clear colourless solution that is prepared and diluted before it is used.
Estonian: See on selge, värvitu lahus, mis valmistatakse ja lahjendatakse enne kasutamist.
English: Its antitumour activity is believed to be due to 3 mechanisms:
Estonian: Selle kasvajavastane toime arvatakse tulenevat 3 mehhanismist:
English: Grade 3 or 4 elevated creatinine occurred in 8% of patients.
Estonian: 3. või 4. astme kreatiniinitõus esines 8% patsientidest.
English: Individual duration remission and survival data for patients who achieved CR or CRp
Estonian: Individuaalse kestusega remissiooni ja elulemuse andmed patsientide kohta, kes saavutasid CR-i või CRP
English: Estimates based on noncompartmental analysis (n = 14 / n = 14)
Estonian: Lahterdamata (noncompartmental) analüüsil põhinevad hinnangud (n = 14 / n = 14)
English: 82515 Wolfratshausen
Estonian: 82515 Wolfratshausen Saksamaa
English: Each box contains 1 vial.
Estonian: Iga karp sisaldab 1 viaali.
English: Clofarabine should not be used during pregnancy unless clearly necessary.
Estonian: Klofarabiini ei tohiks kasutada raseduse ajal, välja arvatud juhul, kui see on tingimata vajalik.
English: Talk to your doctor about contraception.
Estonian: Rääkige oma arstile rasestumisvastastest vahenditest.
English: • No evidence of circulating blasts or extramedullary disease
Estonian: • puuduvad tõendid ringlevate blastide või ekstramedullaarse haiguse kohta
English: Therefore, Ivozall should not be used during pregnancy, especially not during the first trimester, unless clearly necessary (i.e. only if the potential benefit to the mother outweighs the risk to the foetus).
Estonian: Seepärast ei tohi Ivozalli kasutada raseduse ajal, eriti selle esimeses kolmandikus, kui see ei ole hädavajalik (s.t ainult sel juhul, kui selle potentsiaalne kasulikkus emale kaalub üles lootele avalduva riski).
English: This means that because of the rarity of this disease it has been impossible to get complete information on the reference medicine.
Estonian: See tähendab, et harvaesineva haiguse tõttu ei ole olnud võimalik saada võrdlusravimi kohta täielikku teavet.
English: Most of the cardiac adverse reactions were reported in the first 2 cycles.
Estonian: Enamikust südame kõrvaltoimetest teatati esimese 2 tsükli jooksul.
English: The liver is a potential target organ for toxicity.
Estonian: Maks on toksilisuse potentsiaalne sihtelund.
English: Because of the way this medicine works, it will affect your blood and other organs.
Estonian: See ravim mõjutab teie verd ja muid elundeid.
English: Ivozall may harm both male and female reproductive organs.
Estonian: Ivozall võib kahjustada nii meeste kui ka naiste suguelundeid.
English: Haematuria was observed in 13% of patients overall.
Estonian: Hematuuria esines kokku 13% patsientidest.
English: Estimated creatinine clearance (ml/min)
Estonian: Hinnanguline kreatiniini kliirens (ml/min)
English: Adults (> 21 and < 65 years old)
Estonian: Täiskasvanud (vanus > 21 ja < 65 aastat)
English: If you use more Ivozall than you should If you think you may have been given too much medicine, tell your doctor straight away.
Estonian: Kui te kasutate Ivozalli rohkem, kui ette nähtud Kui arvate, et teile võidi anda ravimit liiga palju, rääkige sellest kohe oma arstile.
English: At this time, treatment may be reinitiated at the full dose.
Estonian: Siis võib ravi alustada jälle täisannusega.
English: Your doctor will monitor your health and may change your dose depending on your response to the treatment.
Estonian: Arst jälgib teie tervist ja võib teie annust muuta olenevalt sellest, kuidas te ravile reageerite.
English: As a result, it is not expected to affect the metabolism of active substances which are known substrates for these enzymes.
Estonian: Seepärast ei eeldata, et see mõjutaks selliste toimeainete metabolismi, mis on teadaolevalt nende ensüümide substraadid.
English: No studies on the effects of clofarabine on the ability to drive and use machines have been performed.
Estonian: Ühtegi uuringut klofarabiini mõjude kohta masinate juhtimis- ja kasutamisvõimekusele pole tehtud.
English: PR = Partial remission
Estonian: PR (partial remission) = osaline ravivastus
English: Concentrate (ml)*
Estonian: Kontsentraat (ml)*
English: The 12 patients who achieved an overall remission (CR + CRp) had a median survival time of 66.6 weeks as of the data collection cut-off date.
Estonian: Üldise remissiooni saavutanud 12 patsiendil (CR + CRp) oli andmete kogumise lõpetamise kuupäevaks keskmine elulemus 66,6 nädalat.
English: Body surface area must be calculated using the actual height and weight of the patient before the start of each cycle.
Estonian: Keha pindala arvutamiseks tuleb lähtuda patsiendi tegelikust pikkusest ja kehakaalust enne iga tsükli algust.
English: ITT* patients (n = 61)
Estonian: ITT* patsientid e arv (n = 61)
English: As the effect of clofarabine treatment on human fertility is unknown, reproductive planning should be discussed with patients as appropriate.
Estonian: Kuna klofarabiiniga ravimise mõju inimese viljakusele ei ole teada, tuleb vajaduse korral arutada patsientidega reproduktiivset planeerimist.
English: Elderly (≥ 65 years old)
Estonian: Eakad (vanus ≥ 65 aastat)
English: However, the final dilution volume may vary depending on the patient's clinical status and physician discretion.
Estonian: Lahuse lõplik kogus võib siiski sõltuda patsiendi kliinilisest seisundist ja arsti otsusest.
English: In addition, clofarabine treatment should be discontinued if the patient develops hypotension for any reason during the 5 days of administration.
Estonian: Lisaks tuleb ravi klofarabiiniga lõpetada, kui patsiendil areneb 5-päevase manustamisperioodi ajal mistahes põhjusel hüpotensioon.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/19/1396/001
Estonian: MÜÜGILOA NUMBER (NUMBRID) EU/1/19/1396/001
English: Of the 17 ALL patients, 2 achieved a complete remission (12%; CR) and 2 a partial remission (12%; PR) at varying doses.
Estonian: 17 ALL patsiendist 2 puhul saavutati täielik remissioon (12%; CR) ja 2 puhul osaline remissioon (12%; PR), kasutades erinevaid annuseid.
English: After 24 hours, about 60% of the dose is excreted unchanged in the urine.
Estonian: 24 tunni pärast on ligikaudu 60% annusest eritunud muutunud kujul uriiniga.
English: See section 2 “Ivozall contains sodium”.
Estonian: Vt lõik 2 „Ivozall sisaldab naatriumi“.
English: If you forget to use Ivozall
Estonian: Kui te unustate Ivozalli kasutada
English: If you are pregnant or you become pregnant during treatment with clofarabine, get medical advice immediately.
Estonian: Kui olete rase või rasestute ravi ajal klofarabiiniga, pidage kohe nõu arstiga.
English: However, the majority of these hypotensive events were reported in patients who had confounding severe infections.
Estonian: Enamik neist hüpotensioonijuhtudest esines siiski patsientidel, kellel olid rasked segadust tekitavad infektsioonid.
English: This has occurred more frequently within 30 days of treatment, and in the setting of combination chemotherapy.
Estonian: Need on esinenud sagedamini 30 ravipäeva jooksul ja kombineeritud keemiaravi puhul.
English: The incidence of these toxicities was dependent on both the dose of clofarabine administered and the duration of treatment.
Estonian: Nende toksilisuste sagedus sõltus nii manustatud klofarabiiniannusest kui ka ravi kestusest.
English: A total of 83% of patients experienced at least 1 infection after clofarabine treatment, including fungal, viral and bacterial infections (see section 4.4).
Estonian: Kokku 83% patsientidest tekkis vähemalt 1 infektsioon pärast ravi klofarabiiniga, sealhulgas seen-, viirus- ja bakteriaalsed infektsioonid (vt lõik 4.4).
English: Adult population (including elderly)
Estonian: Täiskasvanud (sealhulgas eakad)
English: Do not use Ivozall - - if you are allergic to clofarabine or any of the other ingredients of this medicine (listed in section 6); - if you are breast-feeding (please read the section “Pregnancy and breast-feeding” below); - if you have severe kidney or liver problems.
Estonian: Ärge kasutage Ivozalli: kui olete klofarabiini või selle ravimi mis tahes koostisosade (loetletud lõigus 6) suhtes allergiline; kui imetate last (palun lugege allpool lõiku “Rasedus ja imetamine”); kui teil on rasked neeru- või maksaprobleemid.
English: The diluted concentrate should be a clear, colourless solution.
Estonian: Lahjendatud kontsentraat peaks olema selge värvitu lahus.
English: Patients who underwent transplant while in continued remission*
Estonian: Patsiendid, kellele tehti siirdamine jätkuva remissiooni ajal*
English: Other exfoliative conditions have also been reported.
Estonian: Teatatud on ka muudest eksfoliatiivsetest haigusseisunditest.
English: Your treatment with Ivozall has been prescribed by a qualified doctor experienced in treating leukaemia.
Estonian: Ravi Ivozalliga on teile määranud kvalifitseeritud arst, kellel on leukeemia ravi kogemus.
English: It works by hindering the growth of abnormal white blood cells, and eventually kills them.
Estonian: Ravimi toime avaldub ebanormaalsete valgete vererakkude kasvu pidurdamises ja lõpuks nende hävitamises.
English: Ivozall contains the same active substance and works in the same way as a ‘reference medicine' already authorised in the EU.
Estonian: Ivozall sisaldab sama toimeainet ja toimib samuti nagu võrdlusravim, millel on müügiluba Euroopa Liidus.
English: Do not use this medicine after the expiry date which is stated on the vial label and box after EXP.
Estonian: Ärge kasutage seda ravimit pärast kõlblikkusaega, mis on märgitud viaali etiketil ja karbil pärast „Kõlblik kuni/EXP”.
English: If the ANC does not recover by 6 weeks from the start of a treatment cycle, a bone marrow aspirate / biopsy should be performed to determine possible refractory disease.
Estonian: Kui ANC ei taastu 6 nädala möödumisel ravitsükli algusest, tuleb haiguse võimaliku ravile halvasti allumise kindlaksmääramiseks võtta luuüdi aspiraat / biopsia.
English: Ivozall is for intravenous use.
Estonian: Ivozall on ette nähtud intravenoosseks kasutamiseks.
English: Ivozall must not be mixed with or concomitantly administered using the same intravenous line as other medicinal products (see section 6.2).
Estonian: Ivozalli ei tohi segada ega manustada samaaegselt teiste ravimitega sama intravenoosse süsteemi kaudu (vt lõik 6.2).
English: • An M1 bone marrow (≤ 5% blasts)
Estonian: • M1 luuüdi (≤ 5% blastidest)
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2).
Estonian: HANKE- JA KASUTUSTINGIMUSED VÕI PIIRANGUD Piiratud tingimustel väljastatav retseptiravim (vt I lisa: Ravimi omaduste kokkuvõte, lõik 4.2).
English: ORPHELIA Pharma 85 boulevard Saint-Michel 75005 PARIS France
Estonian: ORPHELIA Pharma 85 boulevard Saint-Michel 75005 PARIS Prantsusmaa
English: This medicine is subject to additional monitoring.
Estonian: Selle ravimi suhtes kohaldatakse täiendavat järelevalvet.
English: The table below summarises the key efficacy results for this study.
Estonian: Selle uuringu põhilised efektiivsusega seotud tulemused on esitatud kokkuvõtlikult allpool tabelis.
English: • DNA polymerase α inhibition resulting in termination of DNA chain elongation and/or DNA synthesis / repair.
Estonian: • DNA polümeraas alfa inhibeerimine, mis lõpetab DNA ahela pikenemise ja/või DNA sünteesi/ parandamise;
English: Therefore, it is unlikely to interact with active substances which inhibit or induce cytochrome P450 enzymes.
Estonian: Seepärast see tõenäoliselt ei oma koostoimet toimeainetega, mis tsütokroom P450 ensüüme inhibeerivad või indutseerivad.
English: Therefore, a safe and effective dosage recommendation for patients < 1 year old has yet to be established.
Estonian: Seepärast on (< 1 aasta vanused) patsientide puhul soovitatav ohutu ja efektiivne annus veel kindlaks määramata.
English: Pharmacotherapeutic group: Antineoplastic agents, antimetabolites, purine analogues, ATC code: L01BB06.
Estonian: Farmakoterapeutiline grupp: kasvajavastased ained, antimetaboliidid, puriini analoogid, ATCkood: L01BB06.
English: It was also active against quiescent lymphocytes and macrophages.
Estonian: See oli aktiivne ka liikumatute lümfotsüütide ja makrofaagide suhtes.
English: These infections may lead to septic shock, respiratory failure, renal failure, and/or multi-organ failure.
Estonian: Need infektsioonid võivad põhjustada septilist šokki, hingamispuudulikkust, neerupuudulikkust ja/või hulgiorganpuudulikkust.
English: MARKETING AUTHORISATION NUMBER EU/1/19/1396/001
Estonian: MÜÜGILOA NUMBER EU/1/19/1396/001 1 viaal
English: An infusion time of > 2 hours should be considered to help reduce symptoms of anxiety and irritability, and to avoid unduly high maximum concentrations of clofarabine (see section 5.2).
Estonian: Infusiooni kestus peab olema > 2 tunni, et vähendada ärevuse ja ärrituvuse sümptomeid paremini ning vältida klofarabiini ülemäära kõrgeid maksimumkontsentratsioone (vt lõik 5.2).
English: During treatment with Ivozall, your doctor will carry out regular blood tests and other tests to monitor your health.
Estonian: Ravi ajal Ivozalliga teeb arst teie tervise jälgimiseks teile regulaarselt vereanalüüse.
English: CRp = Complete remission in the Absence of Total Platelet Recovery
Estonian: CRp (complete remission in the absence of platelet recovery) = täielik ravivastus ilma trombotsüütide täieliku taastumiseta
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C unless dilution has taken place under controlled and validated aseptic conditions.
Estonian: Kui ravimit ei kasutata kohe, vastutab selle säilitamisaja ja -tingimuste eest kasutaja ning need ei tohi üldjuhul ületada 24 tundi temperatuuril 2 °C…8 °C, välja arvatud juhul, kui lahjendamine on toimunud kontrollitud ja valideeritud aseptilistes tingimustes.
English: CR = Complete remission
Estonian: CR (complete remission) = täielik ravivastus
English: Patients receiving clofarabine may experience vomiting and diarrhoea; they should, therefore, be advised regarding appropriate measures to avoid dehydration.
Estonian: Klofarabiini saavatel patsientidel võib esineda oksendamist ja kõhulahtisust, seetõttu tuleb neid nõustada sobivate dehüdratsiooni vältimise meetmete osas.
English: The patients were enrolled into a single phase I (n = 12) or two phase II (n = 14 / n = 14) safety and efficacy studies, and received multiple doses of clofarabine by intravenous infusion (see section 5.1).
Estonian: Patsiendid kaasati ühte I faasi (n = 12) või kahte II faasi (n = 14 / n = 14) ohutuse- ja efektiivsuseuuringusse ning nad said intravenoosse infusiooni teel mitu klofarabiini annust (vt lõik 5.1).
English: See the section ‘Pregnancy and breast-feeding' below.
Estonian: Vt allpool lõik "Rasedus ja imetamine".
English: Total diluted volume 100 ml
Estonian: Lahjendatud kogus kokku 100 ml
English: For instructions on dilution of the medicinal product before administration (see section 6.6).
Estonian: Juhiseid ravimi lahjendamise kohta enne manustamist (vt lõik 6.6).
English: Nearly all patients (98%) experienced at least one adverse event considered by the study investigator to be related to clofarabine.
Estonian: Peaaegu kõigil patsientidel (98%) tekkis vähemalt üks kõrvaltoime, mida uuringuarst pidas klofarabiiniga seotud kõrvaltoimeks.
English: The majority of patients who respond to clofarabine achieve a response after 1 or 2 treatment cycles (see section 5.1).
Estonian: Enamikul klofarabiinile reageerivatest patsientidest tekib ravivastus pärast 1 või 2 ravitsüklit (vt lõik 5.1).
English: Multivariate analysis showed that the pharmacokinetics of clofarabine are weight dependent and although white blood cell (WBC) count was identified as having an impact on clofarabine pharmacokinetics, this did not appear sufficient to individualise a patient's dosage regimen based on their WBC count.
Estonian: Mitme muutujaga analüüs näitas, et klofarabiini farmakokineetika sõltub kehakaalust, ning kuigi leiti, et valgete vererakkude (WBC) arv mõjutas klofarabiini farmakokineetikat, ei näinud see olevat piisav patsiendi annustamisskeemi individualiseerimiseks tema valgete vererakkude arvu põhjal.
English: It will be given to you as an infusion through a long thin tube which goes into a vein (a drip), or into a small medical appliance that is inserted under the skin (port-a-cath) if you (or your child) have one implanted.
Estonian: Seda manustatakse teile infusioonina pika peene vooliku kaudu veeni (tilgutiga) või naha alla sisestatud väikesesse meditsiiniseadmesse (Port-a-Cath süsteemi), kui see on teile (või teie lapsele) paigaldatud.
English: **Patients alive and in remission at the time of last follow up were censored at that time point for the analysis.
Estonian: **Analüüsi sel hetkel tsenseeriti viimasel järelvisiidil elus ja remissiooniga olnud patsiente.
English: • Recovery of peripheral counts (platelets ≥ 100 x 109/l and ANC ≥ 1.0 x 109/l)
Estonian: • perifeersete arvude taastumine (trombotsüüdid ≥ 100 x 109/l ja neutrofiilide absoluutarv ≥ 1,0 x 109/l)
English: Before enrolling in the trial, 58 of the 61 patients (95%) had received 2 to 4 different induction regimens and 18/61 (30%) of these patients had undergone at least 1 prior haematological stem cell transplant (HSCT).
Estonian: Enne uuringusse kaasamist olid 61 patsiendist 58 (95%) saanud 2 kuni 4 erinevat sissejuhatavat raviskeemi ja 18/61 (30%) neist patsientidest oli teinud läbi vähemalt ühe hematoloogiliste tüvirakkude siirdamise (HSCT).
English: Prophylactic anti-emetic medicinal products should be considered.
Estonian: Tuleb kaaluda profülaktiliselt antiemeetikume.
English: What Ivozall is and what it is used for
Estonian: Mis ravim on Ivozall ja milleks seda kasutatakse
English: Patients who did not undergo transplant
Estonian: Patsiendid, kellele ei tehtud siirdamist CR
English: Two paediatric reports (1.7%) of veno-occlusive disease (VOD) were considered related to study drug.
Estonian: Kaht teadet laste (1,7%) veno-oklusiivsete haiguste (VOD) kohta peeti uuringuravimiga seotuks.
English: Ivozall is a potent antineoplastic agent with potentially significant haematological and non-haematological adverse reactions (see section 4.8).
Estonian: Ivozall on tugev antineoplastiline aine potentsiaalselt oluliste hematoloogiliste ja mittehematoloogiliste kõrvaltoimetega (vt lõik 4.8).
English: If a patient becomes pregnant during treatment with clofarabine, she should be informed of the possible hazard to the foetus.
Estonian: Kui patsient ravi ajal klofarabiiniga rasestub, tuleb teda teavitada võimalikust ohust lootele.
English: No carcinogenicity studies have been performed.
Estonian: Kartsinogeensuse uuringuid ei ole tehtud.
English: Because of the pre-existing immuno-compromised condition of these patients and prolonged neutropaenia that can result from treatment with clofarabine, patients are at increased risk for severe opportunistic infections, including severe sepsis, with potentially fatal outcomes.
Estonian: Nende patsientide juba olemasoleva immuunpuudulikkuse ja pikaajalise neutropeenia tõttu, mis võib tuleneda ravist klofarabiiniga, on patsientidel suurem oht raskete oportunistlike infektsioonide tekkeks, k.a sepsis, mis võib lõppeda surmaga.
English: In addition, clofarabine is unlikely to inhibit any of the major 5 human CYP isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) or to induce 2 of these isoforms (1A2 and 3A4) at the plasma concentrations achieved following intravenous infusion of 52 mg/m2/day.
Estonian: Peale selle klofarabiin tõenäoliselt ei inhibeeri ühtki inimese 5 tähtsamast CYP isovormist (1A2, 2C9, 2C19, 2D6 ja 3A4) ega indutseeri 2 neist isovormidest (1A2 ja 3A4) plasmakontsentratsioonides, mis saavutatakse pärast intravenoosset infusiooni 52 mg/m2 päevas.
English: Although transplantation rate was not a study endpoint, 10/61 patients (16%) went on to receive a HSCT after treatment with clofarabine (3 after achieving a CR, 2 after a CRp, 3 after a PR, 1 patient that was considered a treatment failure by the IRRP and 1 that was considered not evaluable by the IRRP).
Estonian: Kuigi siirdamise määr ei olnud uuringu lõpp-punkt, said 10/61 patsienti (16%) pärast klofarabiiniga ravimist HSCT (3 pärast CR, 2 pärast CRp, 3 pärast CR saavutamist, 1 patsient, kelle ravi IRRP luges ebaõnnestunuks, ja üks, keda IRRP ei saanud hinnata).
English: It works best against cells which are multiplying quickly - such as cancer cells.
Estonian: See toimib kõige paremini kiiresti paljunevate rakkudenäiteks vähirakkude vastu.
English: The majority of the cases were associated with thrombocytopaenia (see section 4.8).
Estonian: Enamik juhtudest olid seotud trombotsütopeeniaga (vt lõik 4.8).
English: However, as clofarabine is not detectably metabolised by the cytochrome P450 (CYP) enzyme system, pathways of non-renal elimination currently remain unknown.
Estonian: Kuna aga klofarabiin ei metaboliseeru avastataval määral tsütokroom P450 (CYP) ensüümisüsteemi kaudu, ei ole neeruvälise elimineerumise teed praegu teada.
English: • Disruption of mitochondrial membrane integrity with the release of cytochrome C and other proapoptotic factors leading to programmed cell death even in non-dividing lymphocytes.
Estonian: • mitokondrite membraani purustamine koos tsütokroom C ja teiste proapoptootiliste tegurite vabastamisega, mis viib programmeeritud rakusurmani isegi mittejagunevate lümfotsüütide korral.
English: Patients should be monitored for signs and symptoms of infection and treated promptly.
Estonian: Patsiente tuleb jälgida infektsiooninähtude ja -sümptomite suhtes ja kiiresti ravida.