FrancophonIA/ELRC3.0 huggingface dataset:
English: In combination with ritonavir
Slovenian: V kombinaciji z ritonavirjem
English: Careful monitoring of patients with regard to sedative effects is warranted.
Slovenian: Potrebno je skrbno spremljanje bolnikov z ozirom na sedacijske učinke.
English: Do not take Invirase if any of the above applies to you.
Slovenian: Ne jemljite zdravila Invirase, če karkoli izmed naštetega velja za vas.
English: For monitoring of blood lipids and glucose reference is made to established HIV treatment guidelines.
Slovenian: Za spremljanje lipidov in glukoze v krvi se lahko sklicujemo na uveljavljene smernice za zdravljenje HIV.
English: • Take Invirase at the same time as your ritonavir (Norvir) capsules.
Slovenian: • Vzemite zdravilo Invirase istočasno z vašimi ritonavir (Norvir) kapsulami.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant product information for these medicinal products.
Slovenian: Pri sočasnem protiretrovirusnem zdravljenju pri bolnikih s hepatitisom B ali C, prosimo, glejte tudi ustrezne podatke o teh zdravilih.
English: Invirase is not recommended for use in combination with cobicistat as dosing recommendations for this combination have not been established.
Slovenian: Zdravila Invirase ni priporočljivo uporabljati v kombinaciji s kobicistatom, ker priporočila za odmerjanje za to kombinacijo niso določena.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze-galaktoze ne smejo jemati tega zdravila.
English: Therefore, before taking this medicine, you should have told your doctor if you suffer from diarrhoea, or if you have allergies (see Section 4) or if you have an intolerance to some sugars (see section “Invirase contains lactose”).
Slovenian: Zaradi tega morate, preden vzamete zdravilo, povedati svojemu zdravniku, če imate drisko ali alergije (glejte poglavje 4) ali intoleranco za nekatere sladkorje (glejte odstavek '' Zdravilo Invirase vsebuje laktozo'').
English: Vasodilators (peripheral) Vincamine i.v.
Slovenian: Vazodilatatorji (periferni) vinkamin i.v.
English: Also included are serious and non-serious adverse reactions from post-marketing spontaneous reports for which a causal relationship to saquinavir cannot be excluded.
Slovenian: V preglednici so vključeni tudi resni in neresni neželeni učinki iz spontanih poročil, iz obdobja po prihodu zdravila na trg, za katere ni mogoče izključiti vzročne povezave s sakvinavirjem.
English: Stevens Johnson syndrome, dermatitis bullous
Slovenian: Stevens-Johnsonov sindrom, bulozne dermatoze
English: Invirase film-coated tablets should be swallowed whole and taken at the same time as ritonavir with or after food (see section 5.2).
Slovenian: Filmsko obložene tablete Invirase je treba pogoltniti cele in jih jemati ob istem času kot ritonavir skupaj s hrano ali po njej (glejte poglavje 5.2).
English: The inducing effect of St. John's wort may persist for at least 2 weeks after cessation of treatment.
Slovenian: Inducirajoči učinek šentjanževke lahko traja še vsaj 2 tedna po prekinitvi zdravljenja.
English: It is a member of a class of medicines called protease inhibitors.
Slovenian: Spada v razred zdravil, imenovanih zaviralci proteaz.
English: • ergot alkaloids - for migraine attacks
Slovenian: • ergot alkaloidi- proti migrenskim napadom,
English: Results are based on total concentrations (protein-bound and unbound).
Slovenian: Rezultati temeljijo na celokupnih koncentracijah sakvinavirja (vezanega na proteine in prostega).
English: It is unknown whether medicinal products which reduce the gastrointestinal transit time could lead to lower saquinavir plasma concentrations.
Slovenian: Ni znano, ali bi lahko zdravila, ki skrajšajo čas prehoda skozi prebavila, povzročila nižje plazemske koncentracije sakvinavirja.
English: Patients should be informed that saquinavir is not a cure for HIV infection and that they may continue to acquire illnesses associated with advanced HIV infection, including opportunistic infections.
Slovenian: Bolnike je treba obvestiti, da sakvinavir ni zdravilo za ozdravitev okužbe s HIV in da lahko še vedno zbolijo za obolenji, povezanimi z napredovalo okužbo s HIV, vključno z oportunističnimi okužbami.
English: High doses of ketoconazole (> 200 mg/day) are not recommended.
Slovenian: Dajanje visokih odmerkov ketokonazola (> 200 mg/dan) ni priporočljivo.
English: In two patients receiving Invirase 600 mg three times daily, cerebrospinal fluid concentrations of saquinavir were negligible when compared to concentrations from matching plasma samples.
Slovenian: Pri dveh bolnikih, ki sta prejemala zdravilo Invirase 600 mg trikrat na dan, so bile koncentracije sakvinavirja v cerebrospinalni tekočini zanemarljive v primerjavi s koncentracijami v ustreznih vzorcih plazme.
English: Pregnancy: Evaluation of experimental animal studies does not indicate direct or indirect harmful effects with respect to the development of the embryo or foetus, the course of gestation and peri- and post-natal development.
Slovenian: Nosečnost: študije na živalih ne kažejo na neposredne ali posredne škodljive vplive na nosečnost, razvoj zarodka/plodu, peri- in postnatalni razvoj.
English: Renal impairment: Renal clearance is only a minor elimination pathway, the principal route of metabolism and excretion for saquinavir being via the liver.
Slovenian: Ledvična okvara: ledvični očistek predstavlja le manjši del poti izločanja, poglavitna pot presnove in izločanja za sakvinavir poteka prek jeter.
English: If Invirase is co-administered with parenteral midazolam it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Slovenian: Če se zdravilo Invirase daje sočasno s parenteralno obliko midazolama, se mora dati v intenzivni enoti ali podobnem okolju, ki zagotavlja natančno klinično spremljanje in ustrezno medicinsko oskrbo v primeru respiratorne depresije in/ali podaljšane sedacije.
English: Saquinavir selectively inhibits the HIV protease, thereby preventing the creation of mature infectious virus particles.
Slovenian: Sakvinavir selektivno zavira proteazo HIV in tako preprečuje dozorevanje infektivnih virusnih delcev.
English: Saquinavir/ritonavir concentrations not measured, no effect is expected.
Slovenian: Koncentracij sakvinavirja/ritonavirja niso merili, učinek se ne pričakuje.
English: Genotypic and phenotypic clinical cut-offs predicting the clinical efficacy of ritonavir boosted saquinavir have been derived from retrospective analyses of the RESIST 1 and 2 clinical studies and analysis of a large hospital cohort (Marcelin et al 2007).
Slovenian: Genotipske in fenotipske klinične znake, iz katerih lahko napovemo klinično učinkovitost zdravljenja s sakvinavirjem s podporno terapijo z ritonavirjem, so ugotovili s pomočjo retrospektivne analize kliničnih študij RESIST 1 in 2 ter analize velike bolnišnične kohorte (Marcelin et al, 2007).
English: For comprehensive dose adjustment recommendations and drug-associated adverse reactions for ritonavir and other medicinal products used in combination with saquinavir, physicians should refer to the Summary of Product Characteristics for each of these medicinal products.
Slovenian: Za poglobljena priporočila pri prilagajanju odmerkov in z zdravili povezane neželene učinke za ritonavir in druga zdravila, uporabljana v kombinaciji s sakvinavirjem, naj zdravniki uporabijo Povzetke glavnih značilnosti zdravila za vsako od teh zdravil.
English: • Take one 100 mg capsule of ritonavir (Norvir) twice a day.
Slovenian: • Vzemite eno 100 mg kapsulo ritonavirja (Norvir) dvakrat na dan.
English: Therefore, when saquinavir is co-administered with ritonavir, consideration should be given to the potential effects of ritonavir on other medicinal products (see the Summary of Product Characteristics for Norvir).
Slovenian: Ob sočasnem dajanju sakvinavirja z ritonavirjem je zato treba upoštevati možne učinke ritonavirja na druga zdravila (glejte Povzetek glavnih značilnosti zdravila za Norvir).
English: In a small, preliminary study, hepatocellular enzyme elevations occurred in 13 % of subjects during the first several weeks of the delavirdine and saquinavir combination (6 % Grade 3 or 4).
Slovenian: V majhni preliminarni študiji so se pojavila zvišanja koncentracij hepatocelularnih encimov pri 13 % oseb v prvih nekaj tednih kombiniranega zdravljenja z delavirdinom in sakvinavirjem (6 % stopnje 3 ali 4).
English: Then go on with the regular schedule as prescribed.
Slovenian: Nato nadaljujte z rednim jemanjem, kot vam je predpisal zdravnik.
English: Hepatocellular changes should be monitored frequently if this combination is prescribed.
Slovenian: Če se predpiše to kombinacijo, je treba hepatocelularne spremembe pogosto spremljati.
English: * Saquinavir Mutation Score Mutations: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I, I62V, G73S/T, V82A/F/S/T, I84V, L90M
Slovenian: * Mutacije, povezane s sakvinavirjem: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I, I62V, G73S/T, V82A/F/S/T, I84V, L90M
English: Table 6: Subject Demographics MaxCmin1 and MaxCmin2†
Slovenian: Preglednica 6: Demografski podatki iz MaxCmin1 in MaxCmin2†
English: What Invirase looks like and contents of the pack
Slovenian: Izgled zdravila Invirase in vsebina pakiranja
English: Increase not thought to be clinically relevant.
Slovenian: Ta porast klinično ni pomembna.
English: Use of unboosted saquinavir with zalcitabine and/or zidovudine has been studied in adults.
Slovenian: Uporabo sakvinavirja brez podporne terapije z zalcitabinom in/ali zidovudinom so proučevali pri odraslih.
English: While the supra-therapeutic dose of Invirase/ritonavir appeared to have a greater effect on the QT interval than the therapeutic dose of Invirase/ritonavir, it is not sure if maximum effect for both doses has been observed.
Slovenian: Medtem ko se zdi, da je imel supraterapevtski odmerek zdravila Invirase/ritonavirja večji učinek na interval QT kot terapevtski odmerek zdravila Invirase/ritonavirja, pa ni zanesljivo, da je bil največji učinek za oba odmerjanja opažen.
English: Mutagenesis: Mutagenicity and genotoxicity studies, with and without metabolic activation where appropriate, have shown that saquinavir has no mutagenic activity in vitro in either bacterial (Ames test) or mammalian cells (Chinese hamster lung V79/HPRT test).
Slovenian: Mutageneza: študije mutagenosti in genotoksičnosti s presnovno aktivacijo ali brez nje, kakor je ustrezalo, so pokazale, da sakvinavir nima mutagenega delovanja in vitro v bakterijskih celicah (Amesov test) ali celicah sesalcev (test HPRT na celicah pljuč kitajskega hrčka V79).
English: Increased concentrations of indinavir may result in nephrolithiasis.
Slovenian: Zvišane koncentracije indinavirja lahko povzročijo nefrolitiazo.
English: Also, changes in laboratory markers (e.g., blood or urine tests) have been reported very commonly.
Slovenian: Zelo pogosto so poročali tudi o spremembah laboratorijskih označevalcev (npr. testi krvi ali urina).
English: Paediatric Patients: Steady state pharmacokinetic information is available from HIV-infected paediatric patients from study NV20911.
Slovenian: Pediatrična populacija: informacija o farmakokinetiki v stanju dinamičnega ravnovesja pri pediatričnih bolnikih, okuženih s HIV, je na voljo iz študije NV20911.
English: Age Group (Years)
Slovenian: Starostna skupina (leta)
English: B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2).
Slovenian: B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE Predpisovanje in izdaja zdravila je le s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
English: The drugs listed above might cause serious side effects if you take them together with Invirase.
Slovenian: Zgoraj navedena zdravila bi lahko povzročila resne neželene učinke, če bi jih jemali skupaj z zdravilom Invirase.
English: What Invirase is and what it is used for What you need to know before you take Invirase How to take Invirase
Slovenian: Kaj je zdravilo Invirase in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Invirase Kako jemati zdravilo Invirase Možni neželeni učinki
English: The association between the number of these saquinavir-associated resistance mutations and virological response was confirmed in an independent clinical study (RESIST 1 and 2) involving a more heavily treatment experienced patient population, including 54% who had received prior saquinavir (p=0.0133, see Table 5).
Slovenian: Povezava med številom mutacij, povezanih z odpornostjo na sakvinavir in virološkim odzivom, je bila potrjena v neodvisni klinični raziskavi (RESIST 1 in 2), ki je vkjučevala že predhodno zdravljeno populacijo, vključno s 54 % bolnikov, ki so predhodno prejeli sakvinavir (p = 0,0133, glejte preglednico 5).
English: Considerations when initiating Invirase therapy: Invirase should not be given as the sole protease inhibitor.
Slovenian: Opombe ob uvajanju zdravljenja z zdravilom Invirase: zdravila Invirase se ne sme dajati kot edini zaviralec proteaze.
English: Table 2: Incidences of Adverse Reactions and marked laboratory abnormalities in clinical studies and post-marketing experience in adult patients.
Slovenian: Preglednica 2: Pogostnost neželenih učinkov in izrazite nenormalnosti laboratorijskih testov iz kliničnih študij in obdobja po prihodu zdravila na trg pri odraslih bolnikih.
English: Although specific studies have not been performed, co-administration of Invirase/ritonavir with medicinal products that are mainly metabolised by CYP3A4 pathway may result in elevated plasma concentrations of these medicinal products.
Slovenian: Čeprav specifične študije niso bile izvedene, sočasno dajanje zdravila Invirase/ritonavirja z zdravili, ki se presnavljajo predvsem prek CYP3A4 poti, lahko povzroči zvišanje plazemskih koncentracij teh zdravil.
English: • electrolyte disturbances, particularly uncorrected hypokalaemia
Slovenian: • motnjami elektrolitov, še zlasti pri nezdravljeni hipokaliemiji,
English: Saquinavir does not induce chromosomal damage in vivo in the mouse micronucleus assay or in vitro in human peripheral blood lymphocytes and does not induce primary DNA damage in vitro in the unscheduled DNA synthesis test.
Slovenian: Sakvinavir ne povzroča poškodb kromosomov in vivo pri mikronukleusnem testu na miših ali in vitro v humanih limfocitih periferne krvi in ne povzroča primarnih poškodb DNK in vitro pri testu nepredvidene sinteze DNK.
English: Invirase/ritonavir may be taken with a number of other medications that are commonly used in HIV infection.
Slovenian: Zdravilo Invirase/ritonavir, lahko jemljete v kombinaciji s številnimi drugimi zdravili, ki se pogosto uporabljajo pri okužbi s HIV.
English: Low dose ritonavir increases the concentration of indinavir.
Slovenian: Nizek odmerek ritonavirja zviša koncentracijo indinavirja.
English: Effects of high fluticasone systemic exposure on ritonavir plasma levels yet unknown.
Slovenian: Učinki visoke sistemske izpostavljenosti flutikazonu na vrednosti ritonavirja v plazmi trenutno še niso znani.
English: Gastric pH has been shown to be only a minor component in the large increase in bioavailability seen when given with food.
Slovenian: Dokazano je bilo, da ima pH v želodcu le manjši vpliv k velikemu povečanju biološke uporabnosti, ki so ga opazili pri jemanju s hrano.
English: • medicines used to treat high blood pressure in the arteries of the lungs (a disease known as pulmonary arterial hypertension) such as bosentan.
Slovenian: • zdravila za zdravljenje visokega krvnega tlaka v pljučnih arterijah (bolezen, znana kot pljučna arterijska hipertenzija), kot je bosentan.
English: Fluticasone propionate ↑ Intrinsic cortisol ↓ 86% (90% CI 82%-89%) Greater effects may be expected when fluticasone propionate is inhaled.
Slovenian: ↑ flutikazonpropionata intrinzične vrednosti kortizola ↓ 86 % (90-% interval zaupanja; 82 %-89 %) Večje učinke lahko pričakujemo pri uporabi inhalacijskih oblik flutikazonpropionata.
English: Patients should also be advised that they might experience undesirable effects associated with coadministered medications.
Slovenian: Bolnikom je treba tudi povedati, da lahko izkusijo neželene učinke, povezane s sočasnim dajanjem drugih zdravil.
English: Excipient with known effect: Lactose monohydrate: 38.5 mg.
Slovenian: Pomožne snovi z znanim učinkom: laktoza monohidrat: 38,5 mg.
English: When used with Invirase/ritonavir, the lowest possible dose of atorvastatin should be administered and the patient should be carefully monitored for signs/symptoms of myopathy (muscle weakness, muscle pain, rising plasma creatinine kinase, see section 4.4).
Slovenian: Kadar se uporablja skupaj z zdravilom Invirase/ritonavirjem, je treba dajati najnižji možen odmerek atorvastatina in bolnika skrbno spremljati za znake oz. simptome miopatije (mišična šibkost, bolečina v mišicah, zvišanje plazemske kreatinin kinaze, glejte poglavje 4.4).
English: Systemic clearance of saquinavir was high, 1.14 l/h/kg (CV 12 %), slightly above the hepatic plasma flow, and constant after intravenous doses of 6, 36 and 72 mg.
Slovenian: Sistemski očistek sakvinavirja je bil visok, 1,14 l/h/kg (CV 12 %), rahlo nad jetrnim pretokom plazme, in stalen po intravenskih odmerkih 6, 36 in 72 mg.
English: However, patients with severe renal impairment have not been studied and caution should be exercised when prescribing saquinavir/ritonavir in this population.
Slovenian: Vendar pa bolnikov s hudo okvaro ledvic niso proučevali, zato je pri predpisovanju sakvinavirja/ritonavirja pri tej populaciji potrebna previdnost.
English: Saquinavir Cmax ↓ 54 %.
Slovenian: Cmax sakvinavirja ↓ 54 %.
English: 6.4 Special precautions for storage This medicinal product does not require any special storage conditions.
Slovenian: 6.4 Posebna navodila za shranjevanje Za shranjevanje zdravila niso potrebna posebna navodila.
English: You should know that Invirase/ritonavir is not a cure for HIV infection and that you may continue to develop infections or other illnesses associated with HIV disease.
Slovenian: Zavedati se morate, da zdravilo Invirase/ritonavir ni zdravilo za ozdravitev okužbe s HIV in da se bodo lahko pojavile okužbe ali druga obolenja, povezana z boleznijo HIV.
English: The clinical relevance of these findings from this study in healthy volunteers to the use of Invirase/ritonavir in HIV-infected patients is unclear, but doses exceeding Invirase/ritonavir 1000/100 mg twice daily should be avoided.
Slovenian: Klinični pomen teh ugotovitev iz študije, izvedene pri zdravih prostovoljcih, pri uporabi zdravila Invirase/ritonavirja pri bolnikih, okuženih s HIV, ni jasen, vendar se je odmerkom zdravila Invirase/ritonavirja, ki presegajo 1000/100 mg dvakrat na dan, treba izogibati.
English: Mean ± SD Saquinavir (%CV) Pharmacokinetic Parameters*
Slovenian: povprečni ± standardni odklon (% CV) farmakokinetičnih parametrov* sakvinavirja
English: Acute and chronic toxicity: Saquinavir was well tolerated in oral acute and chronic toxicity studies in mice, rats, dogs and marmosets.
Slovenian: Akutna in kronična toksičnost: sakvinavir so dobro prenašali v študijah peroralne akutne in kronične toksičnosti pri miših, podganah, psih in dolgorepih ameriških opicah.
English: In vitro experiments have shown that the hepatic metabolism of saquinavir becomes saturable at concentrations above 2 µg/ml.
Slovenian: In vitro poskusi so pokazali, da se presnova sakvinavirja v jetrih zasiti pri koncentracijah nad 2 µg/ml.
English: Other medicinal products Alpha-1 adrenoreceptor antagonist Alfuzosin
Slovenian: Antagonisti alfa-1 adrenoreceptorjev alfuzosin
English: If you stop taking Invirase
Slovenian: Če ste prenehali jemati zdravilo Invirase
English: The study included a control group consisting of 7 HIV-infected patients with normal hepatic function matched with the hepatically impaired patients for age, gender, weight and tobacco use.
Slovenian: V kontrolno skupino v preskušanju je bilo vključenih 7 bolnikov, ki so bili okuženi s HIV in so imeli normalno jetrno funkcijo ter so se ujemali z bolniki z jetrno okvaro v starosti, spolu, telesni masi in uporabi tobačnih izdelkov.
English: Based on in vitro studies, saquinavir is rapidly metabolised to a range of mono- and di-hydroxylated inactive compounds.
Slovenian: Na podlagi in vitro študij se sakvinavir hitro presnavlja v razpon mono- in dihidroksiliranih neaktivnih spojin.
English: If you forget to take Invirase
Slovenian: Če ste pozabili vzeti zdravilo Invirase
English: The combination of Invirase/ritonavir with drugs known to increase the exposure of saquinavir is not recommended and should be avoided when alternative treatment options are available.
Slovenian: Kombinacija zdravila Invirase/ritonavirja z zdravili, za katera je znano, da povečajo izpostavljenost sakvinavirju, se ne priporoča in se ji je treba izogibati, ko so na voljo druge možnosti zdravljenja.
English: Absolute bioavailability averaged 4 % (CV 73 %, range: 1 % to 9 %) in 8 healthy volunteers who received a single 600 mg dose (3 x 200 mg hard capsule) of Invirase following a heavy breakfast.
Slovenian: Absolutna biološka uporabnost je bila v povprečju 4 % (CV 73 %, razpon: 1 % do 9 %) pri 8 zdravih prostovoljcih, ki so prejeli en odmerek po 600 mg (3 x 200 mg trde kapsule) zdravila Invirase po obilnem zajtrku.
English: • certain medicines for severe mental health problems such as pimozide
Slovenian: • nekatera zdravila proti hudim duševnim zdravstvenim težavam - kot je pimozid,
English: Based on the finding of dose-dependent prolongations of QT and PR intervals in healthy volunteers receiving Invirase/ritonavir (see sections 4.3, 4.4 and 5.1), additive effects on QT and PR interval prolongation may occur.
Slovenian: Na podlagi ugotovitve o od odmerka odvisnih podaljšanjih intervalov QT in PR pri zdravih prostovoljcih, ki prejemajo zdravilo Invirase/ritonavir (glejte poglavja 4.3, 4.4 in 5.1), se lahko pojavijo dodatni učinki na podaljšanje intervalov QT in PR.
English: • any heart problems that show on an electrocardiogram (ECG, electrical recording of the heart)
Slovenian: • imate kakršne koli težave s srcem, ki so vidne na elektrokardiogramu (EKG, električni zapis srca) - lahko ste se z njimi že rodili,
English: In the therapeutic and the supra-therapeutic arm 11% and 18% of subjects, respectively, had a QTcS between 450 and 480 msec.
Slovenian: V terapevtski roki je 11 % posameznikov, v supraterapevtski roki pa 18 % posameznikov imelo interval QTcS med 450 in 480 msek.
English: Upper 95%-CI of ddQTcS
Slovenian: Zgornji 95 %interval zaupanja ddQTcS
English: 6.5 Nature and contents of container Plastic bottles (HDPE) containing 120 tablets.
Slovenian: 6.5 Vrsta ovojnine in vsebina Plastenka (HDPE) vsebuje 120 tablet.
English: Interaction unknown.
Slovenian: Medsebojno delovanje ni znano.
English: Dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 (e.g. beclomethasone).
Slovenian: Razmisliti je treba o zmanjšanju odmerka glukokortikoida ob sočasnem skrbnem nadziranju lokalnih in sistemskih učinkov ali o zamenjavi z glukokortikoidom, ki ni substrat za CYP3A4 (npr. beklometazon).
English: Other medicinal products known to increase the plasma concentration of ritonavir-boosted Invirase should be used with caution.
Slovenian: Druga zdravila, za katera je znano, da zvišajo plazemske koncentracije zdravila Invirase s podporno terapijo z ritonavirjem, pa je treba uporabljati previdno.
English: Invirase/ritonavir may increase ergot alkaloids exposure, and consequently, increase the potential for acute ergot toxicity.
Slovenian: Zdravilo Invirase/ritonavir lahko poveča izpostavljenost ergot alkaloidom in posledično poveča možnost za akutno ergot toksičnost.