FrancophonIA/ELRC3.0 huggingface dataset:
English: Hyrimoz 40 mg solution for injection in pre-filled syringe:
Slovenian: Hyrimoz 40 mg raztopina za injiciranje v napolnjeni injekcijski brizgi adalimumab
English: Your doctor will check whether Actos is working 3 to 6 months after you start taking it.
Slovenian: Zdravnik bo preveril, ali zdravilo Actos deluje, 3 do 6 mesecev po tem, ko začnete jemati zdravilo.
English: The estimated volume of distribution in humans is 0.25 L/kg.
Slovenian: Ocenjeni volumen porazdelitve pri človeku je 0,25 l/kg.
English: If you experience any of these, especially if you are over the age of 65, seek medical advice straight away.
Slovenian: Če opazite kar koli od tega, še posebej če ste starejši od 65 let, nemudoma poiščite zdravniško pomoč.
English: You can usually continue to take other medicines whilst you are being treated with Actos.
Slovenian: Običajno lahko še naprej jemljete druga zdravila, medtem ko se zdravite z zdravilom Actos.
English: - if you have or have ever had bladder cancer.
Slovenian: - če imate ali ste kdaj imeli raka sečnega mehurja.
English: FOR CALENDARISED PACKS:
Slovenian: ZA KOLEDARSKA PAKIRANJA:
English: What Actos is and what it is used for
Slovenian: Kaj je zdravilo Actos in za kaj ga uporabljamo
English: The maximum reported dose of 120 mg/day for four days, then 180 mg/day for seven days was not associated with any symptoms.
Slovenian: Najvišji poročani odmerek 120 mg/dan štiri dni, zatem pa 180 mg/dan sedem dni, ni bil povezan s kakršnimi koli simptomi.
English: The safety and efficacy of Actos in children and adolescents under 18 years of age have not been established.
Slovenian: Varnost in učinkovitost zdravila Actos pri otrocih in mladostnikih, mlajših od 18 let, nista bili dokazani.
English: It is recommended that you carry some sugar lumps, sweets, biscuits or sugary fruit juice.
Slovenian: Priporočljivo je, da imate pri sebi nekaj kock sladkorja, bonbone, piškote ali sladek sadni sok.
English: Take Actos daily as prescribed.
Slovenian: Zdravilo Actos jemljite vsak dan, kakor vam je predpisano.
English: Tell your doctor if - you are, you think you might be or are planning to become pregnant.
Slovenian: Povejte zdravniku - če ste noseči, menite, da bi lahko bili noseči ali načrtujete zanositev.
English: nausea or vomiting).
Slovenian: siljenje na bruhanje ali bruhanje).
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo, vključno z zdravili, ki jih lahko dobite brez recepta.
English: See leaflet for further information.
Slovenian: Za nadaljnje informacije glejte navodilo.
English: - if you have had diabetic ketoacidosis (a complication of diabetes causing rapid weight loss,
Slovenian: - če ste imeli diabetično ketoacidozo (zaplet sladkorne bolezni, ki povzroča hitro hujšanje,
English: Actos helps control the level of sugar in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.
Slovenian: Zdravilo Actos pomaga nadzorovati raven sladkorja v krvi, če imate sladkorno bolezen tipa 2, in sicer tako, da telesu pomaga bolje izkoristiti insulin, ki ga izdela.
English: This study showed an increase in reports of heart failure; however this did not lead to an increase in mortality in this study.
Slovenian: Ta študija je pokazala povečanje poročil srčnega popuščanja; vendar to ni vodilo k dvigu smrtnosti v tej študiji.
English: Pioglitazone is contraindicated in patients with:
Slovenian: Pioglitazon je kontraindiciran pri bolnikih:
English: In particular, patients have experienced the following serious side effects:
Slovenian: Pri bolnikih so še posebej poročali o naslednjih resnih neželenih učinkih:
English: not known (frequency cannot be estimated from the available data) - increase in liver enzymes - allergic reactions
Slovenian: neznana pogostnost (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti) - povišanje vrednosti jetrnih encimov - alergijske reakcije
English: Immune System Disorders hypersensitivity and allergic reactions1
Slovenian: Bolezni imunskega sistema preobčutljivostne in alergijske reakcije1
English: The oedema rates for comparator groups (sulphonylurea, metformin) were 2-5%.
Slovenian: Stopnje pojavnosti edemov primerjalnih skupin (sulfonilsečnina, metformin) so bile 2-5%.
English: Date of first authorisation: 13/10/2000 Date of latest renewal: 31/08/2010
Slovenian: Datum zadnjega podaljšanja: 31. avgust 2010
English: If you take Actos with other medicines for diabetes, it is more likely that your blood sugar could fall below the normal level (hypoglycaemia).
Slovenian: Če zdravilo Actos jemljete z drugimi zdravili za zdravljenje sladkorne bolezni, je bolj verjetno, da vrednost krvnega sladkorja pade pod normalno raven (hipoglikemija).
English: Other medicines and Actos
Slovenian: Druga zdravila in zdravilo Actos
English: In some cases weight increase may be a symptom of cardiac failure; therefore weight should be closely monitored.
Slovenian: V nekaterih primerih je povečanje telesne mase lahko simptom srčnega popuščanja; zato je treba telesno maso skrbno spremljati.
English: However, certain medicines are especially likely to affect the amount of sugar in your blood: - gemfibrozil (used to lower cholesterol) - rifampicin (used to treat tuberculosis and other infections) Tell your doctor or pharmacist if you are taking any of these.
Slovenian: Vendar pa nekatera zdravila še posebej verjetno lahko vplivajo na količino sladkorja v krvi: - gemfibrozil (uporablja se za zniževanje holesterola) - rifampicin (uporablja se za zdravljenje tuberkuloze in drugih okužb) Obvestite zdravnika ali farmacevta, če jemljete katero od teh zdravil.
English: Use in children and adolescents under 18 years is not recommended.
Slovenian: Otroci in mladostniki Uporaba tega zdravila pri bolnikih, mlajših od 18 let, ni priporočljiva.
English: de la Industria 30 28108 Alcobendas (Madrid) Spain
Slovenian: de la Industria 30 28108 Alcobendas (Madrid) Španija
English: de la Industria 30, 28108 Alcobendas (Madrid), Spain
Slovenian: de la Industria 30, 28108 Alcobendas (Madrid), Španija
English: - if you have liver disease.
Slovenian: - če imate bolezen jeter.
English: If you forget to take Actos
Slovenian: Če ste pozabili vzeti zdravilo Actos
English: Actos has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Actos nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: Before you start taking Actos you will have a blood sample taken to check your liver function.
Slovenian: Pred začetkom jemanja zdravila Actos vam bodo odvzeli vzorec krvi, da se preveri delovanje jeter.
English: Your doctor will ask you to have blood tests periodically during treatment with Actos.
Slovenian: Zdravnik vas bo v času zdravljenja z zdravilom Actos naročal na redne preiskave krvi.
English: Almost all subjects (95%) were receiving cardiovascular medicinal products (beta blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists, calcium channel blockers, nitrates, diuretics, acetylsalicylic acid, statins, fibrates).
Slovenian: Skoraj vse osebe (95%) so prejemale kardiovaskularna zdravila (zaviralce adrenergičnih receptorjev beta, zaviralce angiotenzinske konvertaze (zaviralce ACE), antagoniste angiotenzina II, zaviralce kalcijevih kanalčkov, nitrate, diuretike, acetilsalicilno kislino, statine, fibrate).
English: It is unclear whether or not there is a direct association between pioglitazone and macular oedema but prescribers should be alert to the possibility of macular oedema if patients report disturbances in visual acuity; an appropriate ophthalmological referral should be considered.
Slovenian: Ni jasno, ali obstaja neposredna povezava med pioglitazonom in makularnim edemom, vendar pa morajo biti zdravniki pozorni na možnost makularnega edema, če bolnik poroča o motnjah vidne ostrine; razmisliti je treba o pregledu pri oftalmologu.
English: However if you miss a dose, just carry on with the next dose as normal.
Slovenian: Če ste pozabili vzeti odmerek, nadaljujte z naslednjim odmerkom kot sicer.
English: These reactions include anaphylaxis, angioedema, and urticaria.
Slovenian: Te reakcije vključujejo anafilaksijo, angioedem in urtikarijo.
English: Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Ireland.
Slovenian: Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Irska Lilly S.A., Avda.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Actos.
Slovenian: Če vam je zdravnik povedal, da imate intoleranco za nekatere sladkorje, se pred uporabo tega zdravila Actos posvetujte s svojim zdravnikom.
English: Epidemiological studies have also suggested a small increased risk of bladder cancer in diabetic patients treated with pioglitazone, although not all studies identified a statistically significant increased risk.
Slovenian: Tudi epidemiološke študije kažejo malo večje tveganje za rak mehurja pri bolnikih s sladkorno boleznijo, zdravljenih s pioglitazonom, čeprav pri vseh študijah povečanje tveganja ni bilo statistično signifikantno.
English: Pioglitazone is indicated as second or third line treatment of type 2 diabetes mellitus as described below:
Slovenian: Zdravilna učinkovina pioglitazon je indicirana kot drugi ali tretji izbor zdravljenja sladkorne bolezni tipa 2, kot je opisano spodaj:
English: Takeda Pharma A/S Dybendal Alle 10 DK-2630 Taastrup Denmark
Slovenian: Takeda Pharma A/S Dybendal Alle 10 DK-2630 Taastrup Danska
English: If you stop taking Actos
Slovenian: Če ste prenehali jemati zdravilo Actos
English: When treating patients who have at least one risk factor for development of congestive heart failure (e.g. prior myocardial infarction or symptomatic coronary artery disease or the elderly), physicians should start with the lowest available dose and increase the dose gradually.
Slovenian: Pri zdravljenju bolnikov, ki imajo vsaj en dejavnik tveganja za razvoj kongestivnega srčnega popuščanja (npr. predhodni miokardni infarkt ali simptomatsko koronarno arterijsko bolezen ali v primeru starejših bolnikov), bi moral zdravnik začeti zdravljenje z najnižjim možnim odmerkom in ga postopoma zviševati.
English: What Actos is and what it is used for What you need to know before you take Actos How to take Actos
Slovenian: Kaj je zdravilo Actos in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Actos Kako jemati zdravilo Actos Možni neželeni učinki
English: These findings were observed across species at plasma concentrations ≤ 4 times the clinical exposure.
Slovenian: Te ugotovitve so potrdila opažanja pri vseh vrstah pri plazemskih koncentracijah  4-kratne plazemske koncentracije pri klinični izpostavitvi.
English: When Actos is taken in combination with other medicines used to treat diabetes (such as insulin, chlorpropamide, glibenclamide, gliclazide, tolbutamide) your doctor will tell you whether you need to take a smaller dose of your medicines.
Slovenian: Če boste zdravilo Actos jemali skupaj z drugimi zdravili za zdravljenje sladkorne bolezni (kot so insulin, klorpropamid, glibenklamid, gliklazid, tolbutamid), vam bo zdravnik povedal, če morate jemati nižje odmerke teh zdravil.
English: Takeda Pharmaceuticals Slovakia s.r.o.
Slovenian: Slovenská republika Takeda Pharmaceuticals Slovakia s.r.o.
English: If you are following a special diet for diabetes, you should continue with this while you are taking Actos.
Slovenian: Če ste na posebni dieti za sladkorno bolezen, morate z dieto med jemanjem zdravila Actos nadaljevati.
English: Cases of bladder cancer were reported more frequently in a meta-analysis of controlled clinical trials with pioglitazone (19 cases from 12,506 patients, 0.15%) than in control groups (7 cases from 10,212 patients, 0.07%) HR=2.64 (95% CI 1.11-6.31, p=0.029).
Slovenian: O primerih raka sečnega mehurja so pogosteje poročali v meta-analizi kontroliranih kliničnih preskušanjih s pioglitazonom (19 primerov od 12.506 bolnikov, 0,15%) kot v kontrolnih skupinah (7 primerov od 10.212 bolnikov, 0,07%) HR=2,64 (95% IZ 1,11-6,31, p=0,029).
English: What you need to know before you take Actos Do not take Actos
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Actos
English: Actos should be used every day to work properly.
Slovenian: Za pravilno delovanje morate zdravilo Actos jemati vsak dan.
English: The other side effects that have been experienced by some patients taking Actos are:
Slovenian: Drugi neželeni učinki, ki so se pojavili pri nekaterih bolnikih, ki so jemali zdravilo Actos, so:
English: 5 Oedema was reported in 6-9% of patients treated with pioglitazone over one year in controlled clinical trials.
Slovenian: O edemih so poročali pri 6-9% bolnikov, zdravljenih s pioglitazonom leto dni v kontroliranih kliničnih preskušanjih.
English: If you have the impression that the effect of Actos is too weak, talk to your doctor.
Slovenian: Če menite, da je učinek zdravila Actos prešibak, se posvetujte z zdravnikom.
English: After excluding patients in whom exposure to study drug was less than one year at the time of diagnosis of bladder cancer, there were 7 cases (0.06%) on pioglitazone and 2 cases (0.02%) in control groups.
Slovenian: Ko so izločili bolnike, ki so bili v času diagnoze rak mehurja preiskovanemu zdravilu izpostavljeni manj kot eno leto, so ugotovili 7 primerov (0,06%) raka mehurja pri pioglitazonu in 2 primera (0,02%) v kontrolnih skupinah.
English: The other side effects that have been experienced by some patients when Actos is taken with other antidiabetic medicines are:
Slovenian: Drugi neželeni učinki, ki so se pojavili pri nekaterih bolnikih, ki so jemali zdravilo Actos skupaj z drugimi antidiabetičnimi zdravili, so:
English: At two years, glycaemic control (defined as HbA1c < 8.0%) was sustained in 69% of patients treated with pioglitazone, compared with 50% of patients on gliclazide.
Slovenian: Po dveh letih je nadzor glikemije (definiran kot HbA1c < 8,0%) vztrajal pri 69% bolnikov, zdravljenih s pioglitazonom, v primerjavi s 50% bolnikov, ki so prejemali gliklazid.
English: If you accidentally take too many tablets, or if someone else or a child takes your medicine, talk to a doctor or pharmacist immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Actos, kot bi smeli Če po nesreči zaužijete preveč tablet ali če kdo drug ali otrok zaužije vaša zdravila, o tem nemudoma obvestite svojega zdravnika ali farmacevta.
English: If ALT levels are increased to 3 x upper limit of normal during pioglitazone therapy, liver enzyme levels should be reassessed as soon as possible.
Slovenian: Če se med zdravljenjem s pioglitazonom ravni ALT zvišajo do 3-kratne zgornje meje normalnih vrednosti, je treba ravni jetrnih encimov čim prej ponovno kontrolirati.
English: 2 Visual disturbance has been reported mainly early in treatment and is related to changes in blood glucose due to temporary alteration in the turgidity and refractive index of the lens as seen with other hypoglycaemic treatments.
Slovenian: 2 O motnjah vida so poročali predvsem zgodaj v poteku zdravljenja, povezane pa so s spremembami vrednosti glukoze v krvi zaradi začasnih sprememb turgidnosti in refrakcijskega indeksa leče, kot jih opažamo tudi pri drugih hipoglikemičnih učinkovinah.
English: If you have a serious allergic reaction, including hives and swelling of the face, lips, tongue, or throat that may cause difficulty in breathing or swallowing stop taking this medicine and talk to your doctor as soon as possible.
Slovenian: V primeru pojava resne alergijske reakcije, ki vključuje koprivnico in otekanje obraza, ustnic, jezika ali žrela, kar lahko povzroči težave z dihanjem ali s požiranjem, takoj prenehajte z jemanjem tega zdravila in nemudoma poiščite zdravniško pomoč.
English: - if you are allergic to pioglitazone or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Actos - če ste alergični na pioglitazon ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Patients receiving pioglitazone had a mean reduction in HbA1c of 0.45% compared with those continuing on insulin alone, and a reduction of insulin dose in the pioglitazone treated group.
Slovenian: Bolniki, ki so prejemali pioglitazon, so imeli povprečno znižan HbA1c za 0,45%, v primerjavi s tistimi, ki so nadaljevali zdravljenje samo z insulinom, in znižan odmerek insulina v skupini zdravljeni s pioglitazonom.
English: Within each system organ class, adverse reactions are presented in order of decreasing incidence followed by decreasing seriousness.
Slovenian: V vsaki skupini organskih sistemov so neželeni učinki razvrščeni najprej po padajoči pogostnosti in nato po padajoči resnosti.
English: Takeda GmbH Tel: 0800 825 3325 medinfo@takeda.de
Slovenian: Deutschland Takeda GmbH Tel: 0800 825 3325 medinfo@takeda.de
English: The fracture incidence calculated was 1.9 fractures per 100 patient years in women treated with pioglitazone and 1.1 fractures per 100 patient years in women treated with a comparator.
Slovenian: Izračunana incidenca zlomov je bila 1,9 zlomov na 100 bolniških let pri ženskah, zdravljenih s pioglitazonom in 1,1 zlom na 100 bolnikov-let pri ženskah, zdravljenih s primerjalnim zdravilom.
English: See section 2 “Actos contains lactose monohydrate”.
Slovenian: Glejte poglavje 2 “Zdravilo Actos vsebuje laktozo monohidrat”.
English: Investigations weight increased6
Slovenian: Preiskave povečanje telesne mase6
English: − The other ingredients are lactose monohydrate, hyprolose, carmellose calcium and magnesium stearate.
Slovenian: - Pomožne snovi so laktoza monohidrat, hiproloza, kalcijev karmelozat in magnezijev stearat.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Actos in all subsets of the paediatric population in type 2 diabetes mellitus.
Slovenian: Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij z zdravilom Actos pri vseh podskupinah pediatrične populacije s sladkorno boleznijo tipa 2 (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Combination with metformin with sulphonylurea with metformin and sulphonylurea with insulin
Slovenian: Kombinacija z metforminom s sulfonilsečnino z metforminom in sulfonilsečnino z insulinom
English: Aluminium/aluminium blisters, packs of 14, 28, 30, 50, 56, 84, 90, 98, 112 and 196 tablets.
Slovenian: Aluminij/aluminij pretisni omoti, pakiranja po 14, 28, 30, 50, 56, 84, 90, 98, 112 in 196 tablet.
English: The tablets are supplied in blister packs of 14, 28, 30, 50, 56, 84, 90, 98, 112 or 196 tablets.
Slovenian: Tablete so na voljo v pretisnih omotih po 14, 28, 30, 50, 56, 84, 90, 98, 112 ali 196 tablet.
English: Actos contains pioglitazone.
Slovenian: Zdravilo Actos vsebuje pioglitazon.
English: common common uncommon macular oedema not known not known not known not known not known
Slovenian: pogosti pogosti občasni makularni edem neznana neznana neznana neznana neznana
English: Lilly Hungária Kft. Tel: +36 1 328 5100
Slovenian: Magyarország Lilly Hungária Kft. Tel: +36 1 328 5100
English: Steady state pharmacokinetics are similar in patients age 65 and over and young subjects.
Slovenian: Farmakokinetika v stanju dinamičnega ravnovesja je pri bolnikih, starih 65 let in več, podobna kot pri mlajših osebah.
English: Hepatic impairment Pioglitazone should not be used in patients with hepatic impairment (see sections 4.3 and 4.4).
Slovenian: Jetrna okvara Pioglitazona pri bolnikih z jetrno okvaro ne smemo uporabljati (glejte poglavji 4.3 in 4.4).
English: It is an anti-diabetic medicine used to treat type 2 (non-insulin dependent) diabetes mellitus in adults, when metformin is not suitable or has failed to work adequately.
Slovenian: Je antidiabetično zdravilo za zdravljenje sladkorne bolezni tipa 2 (od insulina neodvisne sladkorne bolezni) pri odraslih, če zdravljenje z metforminom ni primerno ali ne deluje dovolj dobro.
English: Since insulin and pioglitazone are both associated with fluid retention, concomitant administration may increase the risk of oedema.
Slovenian: Ker sta tako insulin kot pioglitazon povezana z zastajanjem tekočine, lahko sočasno jemanje poveča tveganje za edeme.
English: Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance (see section 4.4).
Slovenian: Pioglitazon je indiciran tudi za kombinacijo z insulinom pri odraslih bolnikih s sladkorno boleznijo tipa 2 z nezadostnim nadzorom glikemije, ki se zdravijo z insulinom, za katere je metformin, zaradi kontraindikacij ali neprenašanja, neprimeren (glejte poglavje 4.4).
English: In animal fertility studies there was no effect on copulation, impregnation or fertility index.
Slovenian: V študijah plodnosti pri živalih ni bilo vpliva na parjenje, oploditev ali rodnost.
English: In the 3.5 year PROactive study, 44/870 (5.1%) of pioglitazone-treated female patients experienced fractures compared to 23/905 (2.5%) of female patients treated with comparator.
Slovenian: V 3,5 letni PROactive študiji je 44/870 (5,1%) žensk, zdravljenih s pioglitazonom imelo zlome, v primerjavi s 23/905 (2,5%) žensk, zdravljenih s primerjalnim zdravilom.
English: common (may affect up to 1 in 10 people) - headache - dizziness - joint pain - impotence - back pain - shortness of breath - small reduction in red blood cell count - flatulence uncommon (may affect up to 1 in 100 people) - sugar in urine, proteins in urine - increase in enzymes - spinning sensation (vertigo) - sweating - tiredness - increased appetite
Slovenian: pogosti (pojavijo se lahko pri največ 1 od 10 bolnikov) - glavobol - omotica - bolečine v sklepih - impotenca - bolečine v hrbtu - težko dihanje - majhno znižanje števila rdečih krvnih celic - vetrovi občasni (pojavijo se lahko pri največ 1 od 100 bolnikov) - sladkor v urinu, beljakovine v urinu - povišanje vrednosti encimov - občutek vrtenja (vrtoglavica) - znojenje
English: A cardiovascular outcome study of pioglitazone has been performed in patients under 75 years with type 2 diabetes mellitus and pre-existing major macrovascular disease.
Slovenian: Študijo s pioglitazonom, kjer so spremljali kardiovaskularni izid, so opravili pri bolnikih, mlajših od 75 let, s sladkorno boleznijo tipa 2 in že obstoječimi težjimi makrovaskularnimi boleznimi.
English: Do not use this medicine after the expiry date which is stated on the carton and the blister pack after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: You may take your tablets with or without food.
Slovenian: Zdravilo Actos skupaj s hrano in pijačo Tablete lahko jemljete skupaj s hrano ali brez nje.
English: If you experience this symptom for the first time, talk to your doctor as soon as possible.
Slovenian: Če ste prvič opazili ta simptom, se čim prej posvetujte s svojim zdravnikom.
English: Musculoskeletal and connective tissue disorders fracture bone4
Slovenian: Bolezni mišičnoskeletnega sistema in vezivnega tkiva zlomi kosti4
English: Pioglitazone did not cause statistically significant increases in LDL cholesterol levels compared with placebo, whilst reductions were observed with metformin and gliclazide.
Slovenian: Pioglitazon ni povzročil statistično pomembnih povišanj ravni LDL holesterola v primerjavi s placebom, pri metforminu in gliklazidu pa so opazili znižanja teh vrednosti.
English: Since there is a potential for an increase in dose-related adverse events, a decrease in the dose of pioglitazone may be needed when gemfibrozil is concomitantly administered.
Slovenian: Ker obstaja možnost povečanja od odmerka odvisnih neželenih učinkov, bo morda ob sočasnem dajanju gemfibrozila treba znižati odmerek pioglitazona.