FrancophonIA/ELRC3.0 huggingface dataset:
English: Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR alpha.
Croatian: Arsenov trioksid također uzrokuje oštećenje ili degradaciju fuzijskog proteina PML/RAR alfa.
English: Tell your doctor or nurse straight away if you notice the following side effects, as these may be signs of a severe condition called “differentiation syndrome”, which might be fatal:
Croatian: Odmah obavijestite svog liječnika ili medicinsku sestru ako primijetite bilo koju od sljedećih nuspojava jer one mogu biti znakovi ozbiljnog stanja zvanog „sindrom diferencijacije” koji može biti smrtonosan:
English: The daily dose can be escalated back to 100% of the original dose if no prolongation occurs.
Croatian: Dnevna doza može se ponovno povisiti na 100% prvobitne doze ako ne nastupi produljenje.
English: APL. Frequencies are defined as: (very common ≥ 1/10), (common ≥ 1/100 to < 1/10), (uncommon ≥
Croatian: Učestalosti se definiraju kao: (vrlo često ≥ 1/10), (često ≥ 1/100 i < 1/10), (manje često ≥ 1/1000 i
English: There are no data on the effect of arsenic trioxide on the QTc interval during the infusion.
Croatian: Nema podataka o učinku arsenovog trioksida na interval QTc tijekom infuzije.
English: is large (>400 L) indicating significant distribution into the tissues with negligible protein binding.
Croatian: Volumen distribucije (Vd) za AsIII je velik (> 400 l) što ukazuje na značajnu raspodjelu u tkiva sa zanemarivim vezivanjem na proteine.
English: It is given as a drip (infusion) into a vein over 1-2 hours, but the infusion may last longer if side effects like flushing and dizziness occur.
Croatian: Daje se kao drip (infuzija) u venu tijekom 1-2 sata, ali infuzija može trajati dulje ako se pojave nuspojave poput navale crvenila i omaglice.
English: The infusion duration may be extended up to 4 hours if vasomotor reactions are observed.
Croatian: Trajanje infuzije može se produljiti do 4 sata ako se primijete vazomotoričke reakcije.
English: Twenty-seven patients had leukocytosis (WBC ≥ 10 x 103/µl) during induction, 4 of whom had values above 100,000/µl.
Croatian: Dvadeset i sedam bolesnika je imalo leukocitozu (leukociti ≥ 10 x 103/µl) tijekom indukcije, a od njih su 4 imala vrijednosti iznad 100 000/µl.
English: Arsenic trioxide dose, mg/kg/day (median, range) Complete remission
Croatian: Doza arsenovog trioksida, mg/kg/dan (medijan, raspon) Potpuna remisija
English: Each pack contains 1, 5 or 10 vials.
Croatian: Pakiranje sadrži 1, 5 ili 10 bočica.
English: - If you are at risk for a certain type of abnormal heart rhythm (e.g. torsade de pointes or QTc prolongation), your heart will be monitored continuously.
Croatian: Ako ste pod rizikom od određenih tipova poremećenog srčanog ritma (primjerice, torsade de pointes ili produljenje QTc intervala), Vaše će srce biti pod stalnim nadzorom.
English: Medicinal products that are used to lower the white blood cell count often exacerbate the toxicities associated with leukocytosis, and no standard approach has proven effective.
Croatian: Lijekovi koji se koriste za snižavanje leukocita često pojačaju toksičnosti povezane s leukocitozom, te se nijedan standardni pristup nije pokazao učinkovitim.
English: Total arsenic accumulates mainly in the liver, kidney, and heart and, to a lesser extent, in the lung, hair, and nails.
Croatian: Ukupni arsen akumulira se uglavnom u jetri, bubrezima i srcu te u manjem opsegu u plućima, kosi i noktima.
English: Substances that are substrates for these P450 enzymes are not expected to interact with arsenic trioxide.
Croatian: Ne očekuje se da će tvari koje su supstrati za ove enzime P450 stupiti u interakciju s arsenovim trioksidom.
English: Must be diluted before use.
Croatian: Razrijediti prije uporabe.
English: For patients with severe, acute arsenic overdose, dialysis should be considered.
Croatian: Za bolesnike s teškim, akutnim predoziranjem arsenom potrebno je uzeti u obzir dijalizu.
English: If you are pregnant or you become pregnant during the treatment with Arsenic trioxide Accord, you must ask your doctor for advice.
Croatian: Ako ste trudni ili zatrudnite tijekom liječenja lijekom Arsenov trioksid Accord, obratite se svom liječniku za savjet.
English: Your doctor will decide exactly how long you must continue on therapy with Arsenic trioxide Accord.
Croatian: Liječnik će točno odrediti koliko dugo morate nastaviti liječenje lijekom Arsenov trioksid Accord.
English: Arsenic trioxide Accord with food and drink
Croatian: Arsenov trioksid Accord s hranom i pićem
English: Patients who are receiving, or who have received, medicinal products known to cause hypokalemia or hypomagnesaemia, such as diuretics or amphotericin B, may be at higher risk for torsade de pointes.
Croatian: Bolesnici koji primaju, ili koji su primali, lijekove za koje se zna da uzrokuju hipokalemiju ili hipomagnezijemiju, poput diuretika ili amfotericina B, mogu biti pod većim rizikom od torsade de pointes.
English: Tell your doctor or nurse straight away if you notice one or more of the following side effects, as these may be signs of allergic reaction:
Croatian: Odmah obavijestite svog liječnika ili medicinsku sestru ako primijetite bilo koju od sljedećih nuspojava jer one mogu biti znakovi alergijskih reakcija:
English: Patients with complete remission received consolidation therapy with arsenic trioxide for 25 additional doses over a 5 weeks period.
Croatian: Bolesnici s potpunom remisijom primili su konsolidacijsku terapiju arsenovim trioksidom od 25 dodatnih doza u razdoblju od 5 tjedana.
English: Concentrate for solution for infusion 1 vial of 10 ml (10 mg/10 ml) 5 vials of 10 ml (10 mg/10 ml) 10 vials of 10 ml (10 mg/10 ml)
Croatian: Koncentrat za otopinu za infuziju 1 bočica s 10 ml (10 mg/10 ml) 5 bočica s 10 ml (10 mg/10 ml) 10 bočica s 10 ml (10 mg/10 ml)
English: PVC-free plastic bags should be used.
Croatian: Potrebno je upotrebljavati plastične vrećice za infuziju koje ne sadrže PVC.
English: For storage conditions after dilution or first opening of the medicinal product, see section 6.3.
Croatian: Uvjete čuvanja nakon razrjeđivanja ili prvog otvaranja lijeka vidjeti u dijelu 6.3.
English: If the toxic event does not recur within 7 days of restarting treatment at the reduced dose, the daily dose can be escalated back to 100% of the original dose.
Croatian: Ako se toksični događaj ne pojavi unutar 7 dana od ponovnog početka liječenja pri smanjenoj dozi, dnevna doza može se ponovno povećati na 100% početne doze.
English: Approximately 15% of the administered arsenic trioxide dose is excreted in the urine as unchanged AsIII.
Croatian: Približno 15% primijenjene doze arsenovog trioksida izlučuje se u mokraći kao nepromijenjeni AsIII.
English: - Blood tests (potassium, calcium, magnesium and liver function) should be repeated during your treatment with Arsenic trioxide Accord.
Croatian: - Krvne pretrage (kalij, kalcij, magnezija i funkcija jetre) moraju se ponoviti tijekom liječenja lijekom Arsenov trioksid Accord.
English: In these studies, leukocytosis was not treated with chemotherapeutic medicinal products.
Croatian: U ovim ispitivanjima, leukocitoza se nije liječila kemoterapeuticima.
English: Patients who experience such reactions that are considered arsenic trioxide related must resume treatment only after resolution of the toxic event or after recovery to baseline status of the abnormality that prompted the interruption.
Croatian: Bolesnici koji osjete takve reakcije koje se smatraju povezane s arsenovim trioksidom moraju nastaviti liječenje samo nakon rješavanja toksičnih događaja ili nakon oporavka na početno stanje abnormalnosti koje je uzrokovalo prekid liječenja.
English: Of 7 patients less than 18 years of age (range 5 to 16 years) treated with arsenic trioxide at the recommended dose of 0.15 mg/kg/day, 5 patients achieved a complete response (see section 4.2).
Croatian: Od 7 bolesnika mlađih od 18 godina (raspon od 5 do 16 godina) koji su liječeni arsenovim trioksidom pri preporučenoj dozi od 0,15 mg/kg/dan, 5 bolesnika postiglo je potpuni odgovor (vidjeti dio 4.2).
English: The majority of patients do not require permanent termination of arsenic trioxide therapy during treatment of the APL differentiation syndrome.
Croatian: Većina bolesnika ne zahtijeva trajan prekid liječenja arsenovim trioksidom tijekom liječenja sindroma diferencijacije APL-a.
English: Arsenic trioxide is indicated for induction of remission, and consolidation in adult patients with:
Croatian: Arsenov trioksid indiciran je za indukciju remisije i konsolidaciju u odraslih bolesnika s:
English: Thereafter, penicillamine at a daily dose ≤ 1 gm per day may be given.
Croatian: Nakon toga se može davati dnevna doza penicilamina ≤ 1 mg po danu.
English: - fever - sudden weight gain - water retention - fainting - palpitations (strong heartbeat you can feel in your chest)
Croatian: - iznenadni porast tjelesne težine - zadržavanje vode - nesvjestica - palpitacije (snažni otkucaji srca koje možete osjetiti u prsima)
English: The effect of these medicines on your heartbeat can be made worse by Arsenic trioxide Accord.
Croatian: Učinak tih lijekova na Vaše otkucaje srca može se pogoršati uzimanjem lijeka Arsenov trioksid
English: You should report any new and exceptional symptoms and circumstances whenever you see your doctor.
Croatian: Nužno je da svaki put kada posjetite liječnika prijavite sve nove i izvanredne simptome i okolnosti.
English: EU/1/19/1398/001 (pack of 1 vial) EU/1/19/1398/002 (pack of 5 vials) EU/1/19/1398/003 (pack of 10 vials)
Croatian: EU/1/19/1398/002 (pakiranje od 5 bočica) EU/1/19/1398/003 (pakiranje od 10 bočica)
English: What Arsenic trioxide Accord is and what it is used for
Croatian: Što je Arsenov trioksid Accord i za što se koristi
English: It is recommended that chemotherapy not be added to treatment with steroids since there is no experience with administration of both steroids and chemotherapy during treatment of the leukocyte activation syndrome due to arsenic trioxide.
Croatian: Preporučuje se da se kemoterapija ne dodaje liječenju steroidima jer nema iskustva s primjenom i steroida i kemoterapije tijekom liječenja sindroma aktivacije leukocita izazvanog arsenovim trioksidom.
English: Dilution: Carefully insert the needle of a syringe into the vial through the rubber stopper and draw up all of the content.
Croatian: Razrjeđivanje: Pažljivo umetnite iglu štrcaljke u bočicu kroz gumeni čep te povucite nagore sav sadržaj.
English: Hepatotoxicity (grade 3-4)
Croatian: Hepatotoksičnost (3.-4. stupnja)
English: Do not use this medicine after the expiry date which is stated on the vial label and the carton.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici bočice i na kutiji.
English: It is used in adult patients with newly diagnosed low-to-intermediate risk acute promyelocytic leukaemia (APL), and in adult patients, whose disease has not responded to other therapies.
Croatian: Koristi se u odraslih bolesnika s novodijagnosticiranom akutnom promijelocitnom leukemijom (APL) niskog do srednjeg rizika te u odraslih bolesnika čija bolest ne reagira na druga liječenja.
English: The key efficacy results are summarised in table 3 below:
Croatian: Ključni rezultati djelotvornosti sažeti su u tablici 3 u nastavku Tablica 3
English: No data are available on patient with variant translocations like t(11;17) (PLZF/RAR alpha).
Croatian: Nema dostupnih podataka o bolesniku s drugačijim translokacijama poput t(11;17) (PLZF/RAR alfa).
English: During therapy with arsenic trioxide, potassium concentrations must be kept above 4 mEq/l and magnesium concentrations must be kept above 1.8 mg/dl.
Croatian: Tijekom liječenja arsenovim trioksidom moraju se držati koncentracije kalija iznad 4 mEq/l, a magnezija iznad 1,8 mg/dl.
English: Induction treatment schedule
Croatian: Raspored indukcijskog liječenja
English: Hydrochloric acid, concentrated (for pH adjustment) Water for injections
Croatian: Kloridna kiselina, koncentrirana (za podešavanje pH) Voda za injekcije
English: What you need to know before you use Arsenic trioxide Accord
Croatian: Što morate znati prije nego što primite Arsenov trioksid Accord
English: QT/QTc prolongation is expected during treatment with arsenic trioxide, and Torsade de pointes and complete heart block have been reported.
Croatian: Produljenje intervala QT/QTc očekuje se tijekom liječenja arsenovim trioksidom, a prijavljeni su i torsade de pointes te potpuni srčani blok.
English: In such cases, treatment must resume at 50% of the preceding daily dose.
Croatian: U takvim se slučajevima liječenje mora nastaviti s 50% prethodne dnevne doze.
English: Arsenic trioxide was administered intravenously over 1 to 2 hours until the bone marrow was free of leukaemic cells, up to a maximum of 60 days.
Croatian: Arsenov trioksid primjenjivan je intravenski tijekom 1 do 2 sata sve dok koštana srž nije bila bez leukemičnih stanica, a maksimalno do 60 dana.
English: Arsenic trioxide Accord is supplied in glass vials as a concentrated, sterile, clear, colourless, aqueous solution .
Croatian: Lijek Arsenov trioksid Accord dostupan je u staklenim bočicama u obliku koncentrirane, sterilne, bistre, bezbojne, vodene otopine.
English: If your doctor gives you more Arsenic trioxide Accord than he/she should
Croatian: Ako primite više lijeka Arsenov trioksid Accord nego što ste trebali
English: AsIII is the pharmacologically active species of arsenic trioxide.
Croatian: AsIII je farmakološki aktivni oblik arsenovog trioksida.
English: Contents of the pack and other information What Arsenic trioxide Accord contains
Croatian: Sadržaj pakiranja i druge informacije Što lijek Arsenov trioksid Accord sadrži
English: Each course of consolidation was initiated at hematological recovery from the previous course defined as absolute neutrophil count >1.5×109/L and platelets >100×109/L.
Croatian: Svaki ciklus konsolidacije započeo je pri hematološkom oporavku od prethodnog ciklusa definiranom kao apsolutni broj neutrofila > 1,5 × 10
English: > 50 x 10
Croatian: > 50 x 103/µl
English: Peripheral neuropathy, characterised by paresthesia/dysesthesia, is a common and well known effect of environmental arsenic.
Croatian: Periferna neuropatija koju karakterizira parestezija/dizestezija čest je i dobro poznati učinak arsena iz okoliša.
English: Medicinal products known to cause QT/QTc interval prolongation, hypokalemia or hypomagnesaemia
Croatian: Lijekovi za koje je poznato da uzrokuju produljenje QT/QTc intervala, hipokalemiju ili hipomagnezijemiju
English: After first opening: Once opened the product should be used immediately.
Croatian: Nakon prvog otvaranja: Lijek se mora upotrijebiti odmah nakon otvaranja.
English: Only 2 relapsed/refractory APL patients discontinued treatment early due to this adverse event and one went on to receive additional arsenic trioxide on a subsequent protocol.
Croatian: Samo su 2 bolesnika s APL-om koji je bio u fazi relapsa/refraktoran na liječenje prekinula liječenje ranije zbog ovog štetnog događaja, a jedan je primio dodatni arsenov trioksid tijekom naknadnog protokola.
English: No formal assessments of pharmacokinetic interactions between arsenic trioxide and other therapeutic medicinal products have been conducted.
Croatian: Nisu provedena službena ispitivanja farmakokinetičkih interakcija između arsenovog trioksida i drugih lijekova.
English: See section 2, “Arsenic trioxide Accord contains sodium”.
Croatian: Pogledajte dio 2, „Lijek Arsenov trioksid Accord sadrži natrij“.
English: 95 % CI for the difference, 2-22 percentage points p<0.001 for noninferiority p = 0.02 for superiority of ATRA+Arsenic trioxide
Croatian: 95% CI za razliku, 2-22 postotnih bodova p < 0,001 za neinferiornost p = 0,02 za superiornost kombinacije ATRA+ arsenov trioksid potpuna hematološka remisija (engl. hematologic complete remission, HCR)
English: There is no experience on the effect of arsenic trioxide on the variant APL containing the t(11;17) and t(5;17) chromosomal translocations.
Croatian: Nema iskustva s učinkom arsenovog trioksida na varijante APL-a s kromosomskim translokacijama t(11;17) i t(5;17).
English: There are no restrictions on your food or drink while you are receiving Arsenic trioxide Accord.
Croatian: Nema ograničenja vezanih uz uzimanje hrane i pića dok ste na terapiji lijekom Arsenov trioksid
English: 200 patients who received arsenic trioxide consolidation cycles (cycle 1 and cycle 2) versus none in the control arm.
Croatian: bolesnika koji su primali konsolidacijske cikluse arsenovog trioksida (ciklus 1 i ciklus 2) dok u kontrolnoj skupini nije bilo nijednog slučaja.
English: Patients with acute promyelocytic leukaemia, whose disease has not responded to other therapies Your doctor will give you Arsenic trioxide Accord once every day as an infusion.
Croatian: Bolesnici s akutnom promijelocitnom leukemijom čija bolest ne reagira na druge terapije Liječnik će Vam svakog dana jedanput dnevno davati lijek Arsenov trioksid Accord kao infuziju.
English: It is for single use only, and any unused portions of each vial must be discarded properly.
Croatian: Lijek je namijenjen samo za jednokratnu primjenu i neiskorišteni dio svake bočice mora se odložiti na ispravan način.
English: The plasma clearance of AsIII in patients with severe renal impairment (creatinine clearance less than 30 mL/min) was 40% lower when compared with patients with normal renal function (see section 4.4).
Croatian: Plazmatski klirens AsIII u bolesnika s teškim oštećenjem bubrega (klirens kreatinina manji od 30 ml/min) bio je 40% niži u usporedbi s bolesnicima normalne bubrežne funkcije (vidjeti dio 4.4).
English: At the first signs that could suggest the syndrome (unexplained fever, dyspnoea and/or weight gain, abnormal chest auscultatory findings or radiographic abnormalities), treatment with arsenic trioxide must be temporarily discontinued and high-dose steroids (dexamethasone 10 mg intravenously twice a day) must be immediately initiated, irrespective of the leukocyte count and continued for at least 3 days or longer until signs and symptoms have abated.
Croatian: Na prve znakove koji bi mogli ukazivati na sindrom (neobjašnjiva vrućica, dispneja i/ili porast tjelesne težine, abnormalni nalazi auskultacije prsnog koša ili radiografske abnormalnosti), mora se privremeno prekinuti liječenje arsenovim trioksidom i mora se odmah započeti s visokim dozama steroida (deksametazon 10 mg intravenski dvaput na dan) neovisno o broju leukocita, i nastaviti s liječenjem najmanje 3 dana ili dulje sve dok se simptomi i znakovi ne povuku.
English: Arsenic trioxide Accord is not recommended in children and adolescents below 18 years of age.
Croatian: Arsenov trioksidNe preporučuje se primjenjivati lijek Arsenov trioksid Accord u djece i adolescenata mlađih od 18 godina.
English: What Arsenic trioxide Accord is and what it is used for What you need to know before you use Arsenic trioxide Accord How to use Arsenic trioxide Accord Possible side effects
Croatian: Što je Arsenov trioksid Accord i za što se koristi Što morate znati prije nego što primite Arsenov trioksid Accord Kako primjenjivati Arsenov trioksid Accord
English: Concentrate for solution for infusion Sterile, clear, colourless, aqueous solution, free from particles having a pH range of 7.7 - 8.3.
Croatian: Sterilna, bistra, bezbojna, vodena otopina, bez vidljivih čestica, s pH u rasponu od 7,7 do 8,3.
English: In case of reappearance of hepatotoxicity, arsenic trioxide must be permanently discontinued.
Croatian: U slučaju ponovne pojave hepatotoksičnosti liječenje arsenovim trioksidom mora se trajno prekinuti.
English: As soon as signs and symptoms have subsided, treatment with arsenic trioxide can be resumed at 50 % of the previous dose during the first 7 days.
Croatian: Čim se znakovi i simptomi povuku, liječenje arsenovim trioksidom može se nastaviti pri 50% prethodne doze tijekom prvih 7 dana.
English: Arsenic trioxide Accord may cause harm to the foetus when used by pregnant women.
Croatian: Lijek Arsenov trioksid Accord može naškoditi plodu ako ga koriste trudne žene.
English: If this medicinal product is used during pregnancy or if the patient becomes pregnant while taking this product, the patient must be informed of the potential harm to the foetus.
Croatian: Ako se ovaj lijek koristi tijekom trudnoće ili ako bolesnica zatrudni dok je na terapiji arsenovim trioksidom, mora se obavijestiti bolesnicu o mogućim štetnim učincima lijeka na plod.
English: Because Arsenic trioxide Accord can harm nursing infants, do not breast-feed while on Arsenic trioxide Accord.
Croatian: S obzirom da lijek Arsenov trioksid Accord može naškoditi dojenčetu, nemojte dojiti dijete dok se liječite lijekom Arsenov trioksid Accord.
English: After recovery, treatment should be resumed at 50 % of the preceding daily dose.
Croatian: Nakon oporavka, potrebno je nastaviti s liječenjem pri 50% prethodne dnevne doze.
English: In the presence of coagulopathy, the oral administration of the chelating agent dimercaptosuccinic acid succimer (DCI) 10 mg/kg or 350 mg/m2 every 8 hours during 5 days and then every 12 hours during 2 weeks is recommended.
Croatian: Ako je prisutna koagulopatija, preporučuje se peroralna primjena kelirajućeg agensa sukcimera dimerkaptosukcinilne kiseline (DCI) 10 mg/kg ili 350 mg/m2 svakih 8 sati tijekom 5 dana i potom svakih 12 sati tijekom 2 tjedna.
English: For QTc greater than 500 msec, corrective measures must be completed and the QTc reassessed with serial ECGs and, if available, a specialist advice could be sought prior to considering using arsenic trioxide.
Croatian: Za QTc intervale veće od 500 ms moraju se dovršiti korektivne mjere te ponovno ispitati QTc serijskim EKG-ovima te se, ako je dostupan, može potražiti savjet specijalista prije razmatranja liječenja arsenovim trioksidom.
English: How to store Arsenic trioxide Accord Contents of the pack and other information
Croatian: Kako čuvati Arsenov trioksid Accord Sadržaj pakiranja i druge informacije
English: - The other ingredients are sodium hydroxide, concentrated hydrochloric acid (for pH adjustment) and water for injections.
Croatian: - Drugi sastojci su natrijev hidroksid, kloridna kiselina, koncentrirana (za podešavanje pH) i voda za injekcije.
English: Biotransformation The metabolism of arsenic trioxide involves oxidation of arsenious acid (AsIII), the active species of arsenic trioxide, to arsenic acid (AsV), as well as oxidative methylation to monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) by methyltransferases, primarily in the liver.
Croatian: Metabolizam arsenovog trioksida uključuje oksidaciju arsenične kiseline (AsIII), aktivnog oblika arsenovog trioksida u arsenovu kiselinu (AsV), kao i oksidativnu metilaciju u monometilarsoničnu kiselinu (MMAV) i dimetilarseničnu kiselinu (DMAV) putem metiltransferaza, prvenstveno u jetri.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2- 8°C, unless dilution has taken place in controlled and validated aseptic conditions.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja u primjeni i uvjeti prije primjene odgovornost su korisnika te uobičajeno ne bi smjeli biti dulji od 24 sata pri temperaturi od 2°C do 8°C, osim kada se razrjeđivanje provodi u kontroliranim i validiranim aseptičkim uvjetima.
English: Prior to initiating therapy with arsenic trioxide, a 12-lead ECG must be performed and serum electrolytes (potassium, calcium, and magnesium) and creatinine must be assessed; preexisting electrolyte abnormalities must be corrected and, if possible, medicinal products that are known to prolong the QT interval must be discontinued.
Croatian: Prije početka liječenja arsenovim trioksidom mora se snimiti 12-kanalni EKG i odrediti elektrolite u serumu (kalij, kalcij i magnezij) te kreatinin; postojeće abnormalnosti u elektrolitima moraju se korigirati i, ako je moguće, prekinuti primjenu lijekova za koje se zna da produljuju QT interval.