FrancophonIA/ELRC3.0 huggingface dataset:
English: The frequency of side effects is classified as follows:
Croatian: Učestalost nuspojava definirana je na sljedeći način:
English: Reductions in haemoglobin, white blood cell count, absolute neutrophils and platelets have been observed in clinical trials.
Croatian: U kliničkim je ispitivanjima uočeno smanjenje hemoglobina, broja bijelih krvnih stanica, apsolutnog broja neutrofila i trombocita.
English: Superficial basal cell carcinoma in adults:
Croatian: Površinski bazeocelularni karcinom kože u odraslih bolesnika
English: • Do not cover the treated area with bandages or other dressings after you have applied Aldara cream.
Croatian: • Nemojte stavljati zavoje ili drugu tkaninu na liječeno područje nakon nanošenja kreme Aldara.
English: Imiquimod has not been evaluated for the treatment of actinic keratoses on the eyelids, the inside of the nostrils or ears, or the lip area inside the vermilion border.
Croatian: Imikvimod krema nije procjenjivana u liječenju aktinične keratoze na kapcima, u nosnicama, ušima, ili na usnama unutar vermiliona.
English: Rub gently into the skin until the cream vanishes.
Croatian: Kremu nježno utrljavajte dok ju koža ne upije.
English: 75008 Paris Tél: +33 (0)1 56 64 10 70
Croatian: Tél: +33 (0)1 56 64 10 70
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Croatian: U slučaju bilo kakvih nejasnoća ili pitanja u vezi s primjenom ovog lijeka, obratite se svojem liječniku i ljekarniku.
English: Application Instructions - (Mon, Wed and Fri)
Croatian: Upute za nanošenje - (ponedjeljak, srijeda i petak)
English: The most frequently reported adverse events from the trials judged probably or possibly related to imiquimod cream are application site disorders, with a frequency of 28.1%.
Croatian: Najčešće prijavljeni štetni događaji u navedenim ispitivanjima, koji su ocijenjeni kao vjerojatno ili moguće povezani s liječenjem imikvimod kremom bile su reakcije na mjestu primjene s učestalošću od 28,1%.
English: Imiquimod cream may weaken condoms and diaphragms, therefore concurrent use with imiquimod cream is not recommended.
Croatian: Imikvimod krema može oslabiti stijenku kondoma i dijafragme te se istodobno korištenje ne preporučuje.
English: Minimal systemic absorption of imiquimod 5% cream across the skin of 58 patients with actinic keratosis was observed with 3 times per week dosing for 16 weeks.
Croatian: Kod 58 bolesnika s aktiničnom keratozom koji su primjenjivali kremu 3 puta tjedno tijekom 16 tjedana primijećena je minimalna sustavna apsorpcija 5% imikvimoda u kremi kroz kožu.
English: Sufficient cream should be applied to cover the treatment area, including one centimetre of skin surrounding the tumour.
Croatian: Potrebno je primijeniti dovoljno kreme kako bi tumor i 1 cm zdrave kože oko tumora bili u potpunost prekriveni.
English: Excipients: isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl hydroxybenzoate (E 218), propyl hydroxybenzoate (E 216), xanthan gum, purified water.
Croatian: Pomoćne tvari: izostearatna kiselina, benzilni alkohol, cetilni alkohol, stearilni alkohol, bijeli vazelin, polisorbat 60, sorbitanstearat, glicerol, metilparahidroksibenzoat (E 218), propilparahidroksibenzoat (E 216), ksantanska guma i pročišćena voda.
English: How to use Aldara cream
Croatian: Kako primjenjivati Aldara kremu
English: Target tumours were histologically confirmed single primary superficial basal cell carcinomas with a minimum size of 0.5 cm and a maximum diameter of 2 cm. Tumours located within 1 cm of the eyes, nose, mouth, ears or hairline were excluded.
Croatian: Ciljni tumori bili su histološki potvrđeni pojedinačni primarni površinski bazeocelularni karcinomi najmanje veličine od 0,5 cm i najvećega promjera od 2 cm.
English: Patient reported adverse reactions from 185 patients treated with imiquimod cream in placebo controlled phase III clinical studies for superficial basal cell carcinoma are presented below.
Croatian: U daljnjemu su tekstu prikazani podaci o nuspojava koje je prijavilo 185 bolesnika tijekom liječenja površinskog bazeocelularnog karcinoma kože koji su liječeni imikvimod kremom u placebo kontroliranim kliničkim ispitivanjima faze III.
English: In very rare cases, severe reactions at the urethral meatus have resulted in dysuria in women (see section 4.4).
Croatian: U vrlo rijetkim slučajevima teške reakcije u području uretralnog ušća dovele do dizurije kod žena.
English: • If you are being treated for genital warts:
Croatian: • Ako liječite genitalne bradavice:
English: Apart from reactions in the skin, other common effects include headache, anorexia, nausea, muscle pain, joint pain and tiredness.
Croatian: Uz reakcije na koži česte nuspojave su i glavobolja, gubitak teka, mučnina, bol u mišićima i zglobovima i umor.
English: Local skin reactions, such as erythema, are probably an extension of the pharmacologic effects of imiquimod cream.
Croatian: Lokalne kožne reakcije, kao što je eritem, vjerojatno su posljedica farmakološkog djelovanja imikvimod kreme.
English: Imiquimod cream should be applied in a thin layer and rubbed on the clean wart area until the cream vanishes.
Croatian: Imikvimod kremu je potrebno primijeniti u tankom sloju na čisto područje s bradavicama i utrljavati dok ju koža ne upije.
English: - Each Aldara 5% cream sachet contains 250 mg of a white to slightly yellow cream.
Croatian: Kako krema Aldara izgleda i sadržaj pakiranja - Svaka vrećica Aldara 5% kreme sadržava 250 mg bijele do blago žute kreme.
English: Patient reported adverse reactions from 252 patients treated with imiquimod cream in vehicle controlled phase III clinical studies for actinic keratosis are presented below.
Croatian: U daljnjemu su tekstu prikazani podaci o nuspojavama koje su prijavila 252 bolesnika liječena imikvimod kremom za aktiničnu keratozu u kontroliranim kliničkim ispitivanjima faze III koje je bilo kontrolirano podlogom.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivost na djelatnu tvar ili na bilo koju od pomoćnih tvari navedenih u dijelu 6.1. 4.4 Posebna upozorenja i mjere opreza pri uporabi
English: Leave Aldara cream on the skin for about 8 hours.
Croatian: 5. Ostavite da krema Aldara djeluje oko 8 sati.
English: What you need to know before you use Aldara cream
Croatian: Što morate znati prije nego počnete primjenjivati Aldara kremu Nemojte primjenjivati Aldara kremu
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTRAŠNJE PAKIRANJE TEKST NA VREĆICI
English: Tumours occurred earlier and in greater number in the group of mice administered the vehicle cream in comparison with the low UVR control group.
Croatian: U skupini miševa koji su dobili podlogu tumori su se pojavili ranije i u većem broju nego kod miševa iz kontrolne skupine koji su bili manje zračeni.
English: Aldara 5% cream imiquimod
Croatian: Aldara 5% krema imikvimod
English: Psychiatric disorders: Insomnia
Croatian: Psihijatrijski poremećaji nesanica depresija razdražljivost
English: How to use Aldara cream 4.
Croatian: Kako primjenjivati Aldara kremu 4. Moguće nuspojave
English: The induction of alpha interferon and other cytokines following imiquimod cream application to genital wart tissue has also been demonstrated in clinical studies.
Croatian: U kliničkim je ispitivanjima dokazana indukcija alfa interferona i drugih citokina u tkivu genitalnih bradavica nakon primjene imikvimod kreme.
English: Some systemic adverse reactions, including back pain (1.1%) and influenza-like symptoms (0.5%) were reported by imiquimod cream patients.
Croatian: Bolesnici koji su primjenjivali imikvimod kremu prijavili su i neke sustavne nuspojave, uključujući bol u leđima (1,1%) i simptome nalik gripi (0,5%).
English: No quantifiable levels (>5 ng/ml) of drug were detected in serum after single or multiple topical doses.
Croatian: Nakon jednokratno ili višekratno topikalno primijenjene doze nije zabilježena mjerljiva razina (>5 ng/ml) u serumu.
English: The risk for recurrence of AK lesions in the treated field (as defined above) was 39.7% (50 of 126 patients) until month 12 for patients treated with imiquimod compared with 50.0% (42 of 84 patients) for patients treated with topical diclofenac, a difference of -10.3% (95% CI: -23.6% to
Croatian: Rizik od ponovne pojave lezija aktiničke keratoze na liječenom području (prema gornjoj definiciji) do 12. mjeseca bio je 39,7% (50 od 126 bolesnika) za bolesnike liječene imikvimodom, u usporedbi s 50,0% (42 od 84 bolesnika) za bolesnike liječene topikalnim diklofenakom, što je razlika od -10,3% (95% CI: -23,6% do 3,3%); te 66,7 % (84 od 126 bolesnika) za liječenje imikvimodom i 73,8% (62 od 84 bolesnika) za topikalni diklofenak do 36. mjeseca, što je razlika od -7,1% (95% CI: -19,0% do
English: Open a new sachet each time you use the cream.
Croatian: Pri svakoj primjeni kreme otvorite novu vrećicu.
English: The cream should be rubbed into the treatment area until the cream vanishes.
Croatian: Kremu je potrebno utrljavati u liječenom području sve dok ju koža ne upije.
English: What you need to know before you use Aldara cream 3.
Croatian: Što je Aldara krema i za što se primjenjuje 2. Što morate znati prije nego počnete primjenjivati Aldara kremu 3.
English: Uncommonly some patients experience changes at the application site (discharge, inflammation, swelling, scabbing, skin breakdown, blisters, dermatitis) or irritability, feeling sick, dry mouth, flulike symptoms and tiredness.
Croatian: Manje česte nuspojave kod nekih bolesnika uključuju reakcije na mjestu primjene kreme (iscjedak, upala, oticanje, stvaranje krasti, pucanje kože, mjehurići, dermatitis) ili razdražljivost, mučninu, suha usta, simptome nalik gripi i umor.
English: How to store Aldara cream
Croatian: Kako čuvati Aldara kremu
English: Common effects include pain, burning, irritation or redness.
Croatian: Česte nuspojave uključuju bol, pečenje, iritaciju i crvenilo.
English: Discard any cream remaining in a sachet after use.
Croatian: Zbrinite svu kremu preostalu u vrećici nakon primjene.
English: For quantity to be applied see section 4.2 Method of administration.
Croatian: Za informacije o potrebnoj količini za nanošenje vidjeti dio 4.2.
English: Apply the cream to the affected area.
Croatian: Nanesite kremu Aldara na zahvaćeno područje.
English: Some systemic adverse reactions, including myalgia (2%) were reported by imiquimod treated patients.
Croatian: Bolesnici koji su liječeni imikvimodom prijavili su i neke sustavne nuspojave, uključujući mijalgiju (2%).
English: After about 8 hours, wash the area where Aldara cream was applied with mild soap and water.
Croatian: 6. Nakon isteka 8 sati operite područje koje je bilo prekriveno kremom blagim sapunom i vodom.
English: • If the treated site becomes too uncomfortable, wash the cream off with mild soap and water.
Croatian: • Ako osjetite nelagodu na liječenom mjestu, kremu isperite blagim sapunom i vodom.
English: Four weeks after finishing this first treatment, your doctor will assess your skin.
Croatian: Vaš će liječnik procijeniti stanje vaše kože.
English: Slovenská republika MEDA Pharma spol.
Croatian: Slovenská republika MEDA Pharma spol. s. r.o.
English: 6.1 List of excipients isostearic acid benzyl alcohol cetyl alcohol stearyl alcohol white soft paraffin polysorbate 60 sorbitan stearate glycerol methyl hydroxybenzoate (E 218) propyl hydroxybenzoate (E 216) xanthan gum purified water.
Croatian: 6.1 Popis pomoćnih tvari izostearatna kiselina benzilni alkohol cetilni alkohol stearilni alkohol vazelin, bijeli polisorbat 60 sorbitanstearat glicerol metilparahidroksibenzoat (E218) propilparahidroksibenzoat (E216) ksantanska guma voda, pročišćena
English: • If you are being treated for actinic keratosis
Croatian: • Ako liječite aktiničnu keratozu:
English: Pharmacotherapeutic group: Chemotherapeutics for topical use, antivirals, ATC Code: D06BB10
Croatian: Farmakoterapijska skupina: kemoterapeutici za topikalnu primjenu, antivirotici.
English: ● If you are being treated for basal cell carcinoma:
Croatian: • Ako liječite bazeocelularni karcinom kože:
English: Application site reactions occurred more frequently after imiquimod than after vehicle, however, incidence and intensity of these reactions were not different from that seen in the licensed indications in adults.
Croatian: Međutim, incidencija i jačina tih reakcija nije se razlikovala od one koja je uočena pri primjeni za odobrene indikacije u odraslih bolesnika.
English: Dolenjska cesta 242c 1000 Ljubljana Tel: +386 1 23 63 180
Croatian: GSP Proizvodi d.o.o. Dolenjska cesta 242c 1000 Ljubljana Tel: +386 59 096 951
English: MEDA Pharmaceuticals A.E. Αγίου Δημητρίου 63
Croatian: MEDA Pharmaceuticals A.E.
English: Uncircumcised males treating warts under the foreskin should retract the foreskin and wash the area daily (see section 4.4).
Croatian: Neobrezani muškarci pri liječenju bradavica na glaviću penisa moraju svakodnevno povlačiti kožu na glaviću penisa i svakodnevno prati to područje (vidjeti dio 4.4).
English: Dispose of any cream left in the sachet after use.
Croatian: Preostalu kremu u vrećici nakon uporabe bacite.
English: Dyspareunia
Croatian: Leicestershire
English: When clinical assessment was also included, clearance judged by this composite endpoint was noted in 75%
Croatian: Uključivanjem kliničke procjene, nestanak ocijenjen tom kompozitnom mjerom ishoda zabilježen je u 75% (139/185) bolesnika.
English: Genital pain male
Croatian: Vanjske genitalne bradavice
English: Uterovaginal prolapse
Croatian: Prijavljivanje nuspojava
English: If any lesions persist, treatment should be repeated for another four weeks.
Croatian: Ako aktinične keratoze na liječenom području nisu nestale, potrebno je ponoviti liječenje tijekom iduća 4 tjedna.
English: Increases in systemic levels of alpha interferon and other cytokines following topical application of imiquimod were demonstrated in a pharmacokinetic study.
Croatian: Tijekom farmakokinetičkog ispitivanja dokazano je povećanje sistemske razine alfa interferona i drugih citokina nakon topikalne primjene imikvimoda.
English: Imiquimod cream should be used with caution in organ transplant patients (refer to section 4.5).
Croatian: Potreban je oprez pri primjeni imikvimod kreme u transplantiranih bolesnika (vidjeti dio 4.5).
English: External genital warts in adults:
Croatian: Vanjske genitalne bradavice kod odraslih pacijenata
English: Urticaria
Croatian: Dojenje
English: In the event of accidental contact, remove cream by rinsing with water.
Croatian: uklonite kremu tako da je isperete vodom.
English: Superficial basal cell carcinoma:
Croatian: Površinski bazeocelularni karcinom kože:
English: External genital warts (3x/ wk,16wks) N = 2292
Croatian: (3 puta tjedno, 16 tjedana) N = 2292
English: Renal and urinary disorders: Dysuria
Croatian: Poremećaji bubrega i mokraćnog sustava dizurija
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati Aldara kremu Ovaj lijek čuvati izvan pogleda i dohvata djece.
English: Rarely, intense local inflammatory reactions including skin weeping or erosion can occur after only a few applications of imiquimod cream.
Croatian: Nakon svega nekoliko nanošenja imikvimod kreme, rijetko može doći do burnih lokalnih upalnih reakcija koje uključuju vlaženje kože ili erozije na koži.
English: Following accidental ingestion, nausea, emesis, headache, myalgia and fever could occur after a single dose of 200 mg imiquimod which corresponds to the content of approximately 16 sachets.
Croatian: Pri slučajnom gutanju jednokratne doze od 200 mg imikvimoda, što je otprilike sadržaj 16 vrećica, mogu se pojaviti mučnina, povraćanje, glavobolja, mijalgija i vrućica.
English: Mylan Pharmaceuticals, S.L.
Croatian: United Kingdom Mylan Products Ltd.
English: Actinic keratosis
Croatian: Aktinična keratoza
English: Imiquimod cream should be used with caution in patients with autoimmune conditions (refer to section 4.5).
Croatian: Potreban je oprez pri primjeni imikvimod kreme u bolesnika koji boluju od autoimunih bolesti (vidjeti dio 4.5).
English: One sachet contains enough cream to cover a wart area of 20 cm2 (approx. 3 square inches).
Croatian: Jedna vrećica sadržava dovoljno kreme za prekrivanje 20 cm područja s bradavicama.
English: Nervous system disorders: Headache
Croatian: Krvožilni poremećaji navale crvenila
English: Aldara 5% cream Imiquimod
Croatian: Aldara 5 % krema imikvimod Za kožu.
English: - Keep this leaflet.
Croatian: Vama važne podatke . - Sačuvajte ovu uputu.
English: A rest period of several days may be taken (see section 4.4) if the local skin reaction to imiquimod cream causes excessive discomfort to the patient, or if infection is observed at the treatment site.
Croatian: Ako lokalna kožna reakcija na imikvimod kremu izazove prekomjernu nelagodu u bolesnika ili ako se pojavi infekcija na liječenom području, liječenje se može prekinuti na nekoliko dana (vidjeti dio 4.4).
English: - The other ingredients are isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl hydroxybenzoate (E 218), propyl hydroxybenzoate (E 216), xanthan gum, purified water (see also section 2 “Aldara cream contains methyl hydroxybenzoate, propyl hydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol”).
Croatian: (E218), propilparahidroksibenzoat (E216), ksantanska guma i pročišćena voda.( pogledajte u odjeljku 2 dio Aldara krema sadržava metilhidroksibenzoat, propilhidroksibenzoat, cetilni alkohol,stearilni alkohol i benzilni alkohol
English: Upper respiratory tract infection Uncommon Vulvitis
Croatian: Infekcije i infestacije infekcija često često pustule često herpes simplex genitalna kandidijaza vaginitis baterijska infekcija gljivična infekcija infekcija gornjih dišnih puteva vulvitis rinitis gripa
English: There is limited experience in the use of imiquimod cream in the treatment of men with foreskinassociated warts.
Croatian: Iskustvo u primjeni imikvimod kreme u liječenju bradavica na prepuciju (kožici penisa) ograničeno je.
English: Pustules
Croatian: OBLIK
English: For those patients with complete clinical clearance of the treated AK field recurrence of AK lesions was evaluated.
Croatian: Ocijenjena je ponovna pojava lezija aktinične keratoze kod bolesnika s potpunim kliničkim izlječenjem liječenog područja zahvaćenog aktiničnom keratozom.
English: - If any get any side effects talk to your doctor or pharmacist.
Croatian: - Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
English: The recommended dose is a single infusion of 1,200 mg over three hours.
Croatian: Preporučena doza za jednu infuziju iznosi 1.200 mg tijekom tri sata.
English: These also included infections caused by MRSA.
Croatian: To je također obuhvaćalo infekcije uzrokovane MRSA-om.
English: The study also looked at the number of patients whose infection was cured after treatment.
Croatian: Ispitivanje je također istražilo broj bolesnika čija je infekcija izliječena nakon terapije.
English: The full EPAR and risk management plan summary for Orbactiv can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Croatian: Cjeloviti EPAR kao i sažetak plana upravljanja rizikom za lijek Orbactiv nalaze se na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Orbactiv on 19 March 2015.
Croatian: Europska komisija izdala je odobrenje za stavljanje u promet koje je za lijek Orbactiv na snazi u Europskoj uniji od 19. ožujka 2015.
English: It works by preventing certain bacteria from making their own cell walls, thereby killing the bacteria.
Croatian: Djeluje sprečavajući određene bakterije da naprave vlastite stanične stijenke, te stoga ubija bakterije.
English: In both studies, the main measure of effectiveness was the number of patients who responded within 3 days of starting treatment with an improvement in their skin in the infected area, lack of fever and no need for additional antibiotic.
Croatian: U oba ispitivanja, glavna mjera djelotvornosti bio je broj bolesnika koji su odgovorili u roku od tri dana od početka terapije poboljšanjem stanja kože u zahvaćenom području, izostankom vrućice i potrebe za dodatnim antibioticima.
English: Other information about Orbactiv
Croatian: Ostale informacije o lijeku Orbactiv
English: What measures are being taken to ensure the safe and effective use of Orbactiv?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Orbactiv?
English: The CHMP considered that these side effects were manageable and adequately addressed in the product information.
Croatian: CHMP je zaključio da je te nuspojave moguće upravljati i primjereno navedene u informacijama o proizvodu.
English: Why is Orbactiv approved?
Croatian: Zašto je Orbactiv odobren?
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) decided that Orbactiv's benefits are greater than its risks and recommended that it be approved for use in the EU.
Croatian: Odbor za lijekove za humanu uporabu (CHMP) pri Agenciji odlučio je da koristi od lijeka Orbactiv nadmašuju s njim povezane rizike te je preporučio njegovo odobrenje za korištenje u Europskoj uniji.
English: This is a summary of the European public assessment report (EPAR) for Orbactiv.
Croatian: Ovo je sažetak europskoga javnog izvješća o ocjeni dokumentacije (EPAR) o lijeku Orbactiv.
English: What is Orbactiv and what is it used for?
Croatian: Što je Orbactiv i za što se koristi?
English: Before using Orbactiv, doctors should consider official guidance on the appropriate use of antibiotics.
Croatian: Prije primjene lijeka Orbactiv liječnici trebaju proučiti službene smjernice o odgovarajućoj primjeni antibiotika.
English: Patients who have received Orbactiv must not be given an infusion of unfractionated heparin (a medicine used to prevent blood clots) for 120 hours after the infusion of Orbactiv.
Croatian: Bolesnici koji primaju Orbactiv ne smiju primati infuziju nefrakcioniranog heparina (lijeka koji se koristi za sprječavanje krvnih ugrušaka) tijekom 120 sati nakon infuzije lijeka Orbactiv.
English: In addition, 82.7% of patients treated with Orbactiv in the first study and 79.6% in the second study were cured, compared with 80.5% and 80.0% respectively of patients treated with vancomycin.
Croatian: Nadalje, 82,7 % bolesnika liječenih lijekom Orbactiv u prvom ispitivanju i 79,6 % u drugom ispitivanju bilo je izliječeno, u usporedbi s 80,5 %, odnosno 80,0 % bolesnika liječenih vankomicinom.
English: Orbactiv has been shown to work against bacteria (such as methicillin resistant Staphylococcus aureus (MRSA)) for which standard antibiotics do not work.
Croatian: Dokazano je da lijek Orbactiv djeluje protiv bakterija (poput bakterije Staphylococcus aureus otporne na metilicin (MRSA)) na koje standardni antibiotici ne djeluju.
English: A risk management plan has been developed to ensure that Orbactiv is used as safely as possible.
Croatian: Pripremljen je plan upravljanja rizikom kako bi se osigurala što sigurnija primjena lijeka Orbactiv.
English: It contains the active substance oritavancin.
Croatian: Sadrži djelatnu tvar oritavancin.
English: The most common side effects that resulted in treatment being stopped were cellulitis and osteomyelitis (bone infection).
Croatian: Najčešće nuspojave koje su rezultirale prekidom terapije su celulitis i osteomijelitis (infekcija kostiju).