FrancophonIA/ELRC3.0 huggingface dataset:
English: It should be administered as adjuvant therapy following resection: twice weekly at least 3 days apart for 12 weeks, followed by once-weekly treatments for an additional 24 weeks for a total of 48 infusions in 36 weeks.
Slovenian: Uporabljati ga je treba kot adjuvantno zdravljenje po operacijski odstranitvi: dvakrat tedensko z najmanj 3-dnevnim vmesnim presledkom v obdobju 12 tednov, nato pa enkrat tedensko še dodatnih 24 tednov, skupno 48 infuzij v 36 tednih.
English: However, no specific subset analyses for efficacy are available in patients < 18 years of age and ≥ 18 years of age.
Slovenian: Vendar pa za bolnike, stare < 18 let in ≥ 18 let, ni na voljo nobenih posebnih analiz učinkovitosti po podskupinah.
English: If you stop using MEPACT
Slovenian: Če ste prenehali uporabljati zdravilo MEPACT
English: It stimulates your immune system to help your body kill tumour cells.
Slovenian: Zdravilo spodbuja imunski sistem, da le-ta telesu pomaga uničevati tumorske celice.
English: The schedule of your MEPACT treatments can be adjusted to fit with your chemotherapy schedule.
Slovenian: Urnik zdravljenja z zdravilom MEPACT se lahko prilagodi vašemu urniku kemoterapije.
English: In sensitive species (rabbit and dog) the highest daily dose of liposomal mifamurtide that did not cause adverse effects was 0.1 mg/kg, corresponding to 1.2 and 2 mg/m2, respectively.
Slovenian: Pri občutljivih vrstah (kuncih in psih) je največji dnevni odmerek liposomskega mifamurtida, ki ni povzročil neželenih učinkov, znašal 0,1 mg/kg, kar ustreza 1,2 oz. 2 mg/m2.
English: Takeda France SAS Immeuble Pacific 11-13 Cours Valmy 92800 - Puteaux France
Slovenian: Takeda France SAS Immeuble Pacific 11-13 Cours Valmy 92800 - Puteaux Francija
English: Mifamurtide treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of osteosarcoma.
Slovenian: Zdravljenje z mifamurtidom morajo uvesti in nadzorovati zdravniki specialisti, ki imajo izkušnje z diagnosticiranjem in zdravljenjem osteosarkoma.
English: It can also be administered as an outpatient.
Slovenian: Prejemate ga lahko tudi kot ambulantni bolnik.
English: The mean area under the curve (AUC) was 17.0 ± 4.86 h x nM and Cmax (maximum concentration) was 15.7 ± 3.72 nM.
Slovenian: Povprečna površina pod krivuljo (AUC) je bila 17,0 ± 4,86 h x nM, vrednost Cmax (največja koncentracija) pa 15,7 ± 3,72 nM.
English: It may be difficult to distinguish allergic reactions from exaggerated inflammatory responses, but patients should be monitored for signs of allergic reactions.
Slovenian: Med alergijskimi reakcijami in povečanimi vnetnimi odzivi je težko razlikovati, vendar pa je treba bolnike nadzirati glede pojava znakov alergijskih reakcij.
English: MEPACT is used to treat osteosarcoma (bone cancer) in children, adolescents and young adults (between 2 and 30 years).
Slovenian: Zdravilo MEPACT uporabljamo za zdravljenje osteosarkoma (kostnega raka) pri otrocih, mladostnikih in mladih odraslih (starih od 2 leti do 30 let).
English: MEPACT contains the active substance mifamurtide, similar to a component of the cell wall of certain bacteria.
Slovenian: Zdravilo MEPACT vsebuje učinkovino mifamurtid, ki je podobna sestavini celične stene nekaterih bakterij.
English: Dehydration, Hypokalaemia, Decreased appetite
Slovenian: Dehidracija, Hipokaliemija, Zmanjšan apetit
English: Other medicines and MEPACT
Slovenian: Druga zdravila in zdravilo MEPACT
English: MTP-PE is a specific ligand of NOD2, a receptor found primarily on monocytes, dendritic cells and macrophages.
Slovenian: MTP-PE je specifičen ligand NOD2, receptorja, ki ga najdemo predvsem na monocitih, dendritičnih celicah in makrofagih.
English: - corticosteroids, used to treat inflammations, allergies or asthma.
Slovenian: - kortikosteroide, ki se uporabljajo za zdravljenje vnetij, alergij ali astme.
English: Materials required but not provided:
Slovenian: Potrebni materiali, ki niso priloženi:
English: Cyanosis, Palpitations
Slovenian: Cianoza, Palpitacije
English: The filter and syringe must not be removed from the vial.
Slovenian: Filtra in brizge ne smete odstraniti iz viale.
English: Although these studies are not conclusive, there is no evidence of interference of mifamurtide with the anti-tumour effects of chemotherapy and vice versa.
Slovenian: Te študije sicer ne dajejo dokončnega odgovora, vendar pa ni dokazov, da bi mifamurtid vplival na protitumorske učinke kemoterapije in obratno.
English: MTP-PE is a potent activator of monocytes and macrophages.
Slovenian: MTP-PE je močan aktivator monocitov in makrofagov.
English: The exact mechanism by which mifamurtide activation of monocytes and macrophages leads to anti-tumour activity in animals and humans is not yet known.
Slovenian: Natančen mehanizem, s katerim mifamurtid aktivira monocite in makrofage, kar vodi v protitumorno aktivnost pri živalih in ljudeh, še ni znan.
English: Do not refrigerate or freeze the solution.
Slovenian: Suspenzije ne shranjujte v hladilniku in je ne zamrzujte.
English: If a severe respiratory reaction occurs, administration of mifamurtide should be discontinued and appropriate treatment initiated.
Slovenian: Če pride do hude respiratorne reakcije, je treba uporabo mifamurtida prekiniti in uvesti ustrezno zdravljenje.
English: Although hearing loss may be attributable to ototoxic chemotherapy, like cisplatin, it is unclear whether MEPACT in conjunction with multi-agent chemotherapy may increase hearing loss.
Slovenian: Čeprav je izgubo sluha mogoče pripisati ototoksični kemoterapiji, kot je cisplatin, ni jasno, ali lahko zdravilo MEPACT skupaj s polikemoterapijo poveča izgubo sluha.
English: Instructions for preparation of MEPACT for intravenous infusion
Slovenian: Navodila za pripravo zdravila MEPACT za intravensko infundiranje
English: It will be given to you twice a week (at least three days apart) for the first 12 weeks, then once a week for 24 more weeks.
Slovenian: V prvih 12 tednih zdravljenja ga boste prejeli dvakrat na teden (z vsaj tridnevnim vmesnim presledkom), v nadaljnjih 24 tednih zdravljenja pa enkrat na teden.
English: It is not necessary to interrupt your schedule of MEPACT if your chemotherapy is delayed; you should complete 36 weeks (9 months) of treatment with MEPACT without an interruption.
Slovenian: Urnika zdravljenja z zdravilom MEPACT ni treba spreminjati, če se vaša kemoterapija prestavi Zdravljenje z zdravilom MEPACT je treba zaključiti v 36 tednih (9 mesecih) brez prekinitve.
English: The safety of liposomal mifamurtide has been assessed in more than 700 patients with various kinds and stages of cancer and in 21 healthy adult subjects (see section 4.8).
Slovenian: Varnost liposomskega mifamurtida je bila ocenjena pri več kot 700 bolnikih z različnimi vrstami raka v različnih stadijih ter pri 21 zdravih odraslih preiskovancih (glejte poglavje 4.8).
English: Chemical and physical stability has been demonstrated for 6 hours up to 25 ºC.
Slovenian: Ugotovljena je bila kemijska in fizikalna stabilnost 6 ur pri temperaturi do 25 ºC.
English: Contact your doctor immediately: - if you have continuing fever or chills more than 8 hours after your dose of MEPACT,
Slovenian: Zdravnika takoj obvestite: - če imate zvišano telesno temperaturo ali mrzlico neprekinjeno več kot 8 ur po odmerku zdravila
English: MEPACT will be administered only under the supervision of a specialist physician.
Slovenian: Zdravilo MEPACT boste prejeli pod nadzorom zdravnika specialista.
English: On the basis of the scientific conclusions for mifamurtide the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing mifamurtide is unchanged subject to the proposed changes to the product information.
Slovenian: Na podlagi znanstvenih zaključkov za mifamurtid odbor CHMP meni, da je razmerje med koristjo in tveganjem zdravil(-a), ki vsebuje(-jo) mifamurtid nespremenjeno ob upoštevanju predlaganih sprememb v informacijah o zdravilu.
English: These data indicate that neither total nor free mifamurtide accumulated during the treatment period.
Slovenian: Ti podatki kažejo, da se med zdravljenjem ni kopičil ne skupni ne prosti mifamurtid.
English: • 1 vial of MEPACT (mifamurtide)
Slovenian: • 1 viala zdravila MEPACT (mifamurtid)
English: if you have a history of inflammatory or autoimmune disease or have been treated with corticosteroids or other medicines that may affect your immune system.
Slovenian: - če imate ali ste kdaj imeli vnetno ali avtoimunsko bolezen ali ste se zdravili s kortikosteroidi ali z drugimi zdravili, ki lahko vplivajo na imunski sistem.
English: A fever with a low white blood cell count (neutropenia) may be a sign of serious infection.
Slovenian: Zvišana telesna temperatura ob sočasnem zmanjšanju števila belih krvnih celic (nevtropeniji) je lahko znak resne okužbe.
English: Fever or chills persisting for more than 8 hours after administration of mifamurtide should be evaluated for possible sepsis.
Slovenian: Pri zvišanju telesne temperature ali mrzlici, ki traja več kot 8 ur po uporabi mifamurtida, je treba presoditi, če gre za možno sepso.
English: Store in a refrigerator (2 C-8 C).
Slovenian: Shranjujte v hladilniku (2 C - 8 C).
English: if you have any allergic reactions to any medicines such as rash, breathlessness and high blood pressure.
Slovenian: - če imate kakršno koli alergijsko reakcijo na katero koli zdravilo, kot so izpuščaj, težko dihanje in visok krvni tlak.
English: The majority of patients experience chills, fever and fatigue especially during the first administration of MEPACT.
Slovenian: Pri večini bolnikov se je pojavila mrzlica, zvišana telesna temperatura in utrujenost, še posebej pri prvi uporabi zdravila MEPACT.
English: Two patients with pre-existing asthma developed mild to moderate respiratory distress associated with the treatment (see section 4.8).
Slovenian: Pri dveh bolnikih s predhodno obstoječo astmo se je pojavila blaga do zmerna dihalna stiska, povezana z zdravljenjem (glejte poglavje 4.8).
English: Regular use of corticosteroids should be avoided when using MEPACT as this may affect the way the medicine works.
Slovenian: Med zdravljenjem z zdravilom MEPACT se morate izogibati redni uporabi kortikosteroidov, saj ta lahko vpliva na delovanje zdravila.
English: The liposomal suspension is infused intravenously over about 1 hour.
Slovenian: Intravensko infundiranje liposomske suspenzije traja približno 1 uro.
English: abdomen, arm or leg - cough, trouble breathing or rapid breathing - low body temperature - low number of red blood cells
Slovenian: prsnem košu, trebuhu, rokah ali nogah - kašelj, oteženo dihanje ali hitro dihanje - nizka telesna temperatura - majhno število rdečih krvnih celic
English: In a separate study in 14 patients, mean serum concentration-time curves of total and free mifamurtide that were assessed after the first infusion of mifamurtide and after a last infusion 11 or 12 weeks later, were almost superimposable and the mean AUC values of the free mifamurtide after the first and last infusion were similar.
Slovenian: V ločeni študiji, v kateri je sodelovalo 14 bolnikov, so se povprečne krivulje koncentracije skupnega in prostega mifamurtida v serumu v odvisnosti od časa, ki so bile ocenjene po prvi infuziji mifamurtida in po zadnji infuziji 11 ali 12 tednov kasneje, skoraj pokrivale, povprečne vrednosti AUC prostega mifamurtida po prvi in zadnji infuziji pa so bile podobne.
English: Mifamurtide (muramyl tripeptide phosphatidyl ethanolamine, MTP-PE) is a fully synthetic derivative of muramyl dipeptide (MDP), the smallest naturally-occurring immune stimulatory component of cell walls from Mycobacterium sp.
Slovenian: Mifamurtid (muramil tripeptid fosfatidil etanolamin, MTP-PE) je povsem sintetičen derivat muramil dipeptida (MDP), najmanjše naravno prisotne sestavine celičnih sten Mycobacterium sp., ki stimulira imunost.
English: What you need to know before you use MEPACT
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo MEPACT
English: If symptoms are persistent and worsening, administration should be delayed or discontinued.
Slovenian: Če simptomi ne izginejo in se poslabšajo, je treba uporabo zdravila preložiti ali prekiniti.
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy should be made taking into account the benefit of breast-feeding to the child and the benefit of mifamurtide therapy to the woman.
Slovenian: Odločiti se je treba med prenehanjem dojenja in prenehanjem/prekinitvijo zdravljenja z mifamurtidom, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
English: It is used after you have had surgery to remove the tumour and together with chemotherapy to kill remaining cancer cells to reduce the risk of cancer coming back.
Slovenian: Zdravilo uporabljamo po kirurški odstranitvi tumorja skupaj s kemoterapijo za uničevanje preostalih rakastih celic, da se zmanjša tveganje za ponovitev raka.
English: Mifamurtide was studied as a single agent in 248 patients with mostly advanced malignancies during the early, single arm phase I and II clinical studies.
Slovenian: Mifamurtid so raziskovali kot samostojno zdravilo pri 248 bolnikih z večinoma napredovalimi malignimi novotvorbami v zgodnjih enoskupinskih kliničnih študijah I. in II.
English: MEPACT is then infused directly into your vein (intravenous) over about 1 hour.
Slovenian: Zdravilo MEPACT se nato infundira neposredno v veno (intravensko) približno 1 uro.
English: Activation of human macrophages by mifamurtide is associated with production of cytokines, including tumour necrosis factor (TNF-), interleukin-1 (IL-1), IL-6, IL-8, and IL-12 and adhesion molecules, including lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1).
Slovenian: Aktivacija človeških makrofagov z mifamurtidom je povezana s produkcijo citokinov, vključno s faktorjem tumorske nekroze (TNF-), interlevkinom-1 (IL-1), IL-6, IL-8 in IL-12, ter adhezijskih molekul, ki zajemajo z delovanjem limfocita povezan antigen-1 (LFA-1) in intercelularno adhezijsko molekulo-1 (ICAM-1).
English: For further instructions on reconstitution, filtering using the filter provided and dilution of the medicinal product before administration, see section 6.6.
Slovenian: Za dodatna navodila glede rekonstitucije, filtriranja s priloženim filtrom in redčenja zdravila pred uporabo glejte poglavje 6.6.
English: You should not stop treatment with MEPACT before finishing the course of treatment without discussing with your doctor first.
Slovenian: Predvidenega poteka zdravljenja z zdravilom MEPACT ne smete prekiniti ne da bi se prej o tem posvetovali z zdravnikom.
English: Gastrointestinal toxicity may be exacerbated when mifamurtide is used in combination with high dose, multi-agent chemotherapy and was associated with an increased use of parenteral nutrition.
Slovenian: Gastrointestinalna toksičnost se lahko poslabša, če se mifamurtid uporablja v kombinaciji s polikemoterapijo v visokih odmerkih in je bila povezana s pogostejšo uporabo parenteralne prehrane.
English: • 1 single use 60 or 100 mL sterile syringe with luer lock
Slovenian: • 1 60- ali 100-ml sterilna injekcijska brizga za enkratno uporabo z luer lock nastavkom
English: In a randomised phase III study of 678 patients (age range from 1.4 to 30.6 years) with newly-diagnosed resectable high-grade osteosarcoma, the addition of adjuvant mifamurtide to chemotherapy (either doxorubicin cisplatin and methotrexate with or without ifosfamide), significantly increased the 6-year overall survival and resulted in a relative reduction in the risk of death by 28% (p = 0.0313, hazard ratio (HR) = 0.72 [95% confidence interval (CI): 0.53, 0.
Slovenian: V randomizirani študiji III. faze, v kateri je sodelovalo 678 bolnikov (starih od 1,4 do 30,6 let) z novo diagnosticiranim operabilnim osteosarkomom visoke stopnje, je dodajanje mifamurtida kot adjuvanta kemoterapiji (z doksorubicinom ali cisplatinom in metotreksatom z ali brez ifosfamida) v veliki meri povečalo 6-letno skupno preživetje in povzročilo relativno zmanjšanje tveganja za smrt za 28% (p = 0,0313, razmerje tveganja (HR) = 0,72 [95% interval zaupanja (CI): 0,53, 0,97]).
English: During mifamurtide administration, patients should be monitored for unusual signs or symptoms, such as arthritis or synovitis, suggestive of uncontrolled inflammatory reactions.
Slovenian: Med uporabo mifamurtida je treba bolnike nadzirati glede pojava neobičajnih znakov ali simptomov, kot sta artritis ali sinovitis, ki kažejo na nenadzorovane vnetne reakcije.
English: Pharmacokinetic variability was higher in the moderate hepatic impairment group (co-efficient of variation in systemic exposure [AUCinf] was 50% versus < 30% in the other hepatic function groups).
Slovenian: V skupini z zmerno okvaro jeter je bila variabilnost farmakokinetike večja (koeficient variacije sistemske izpostavljenosti [AUCinf] je znašal 50% v primerjavi z < 30% v skupinah z drugačnim delovanjem jeter).
English: because this may be a sign of an infection, or - if you experience rash or have any problems breathing (wheezing), or - if you experience any stomach problems.
Slovenian: MEPACT, saj je to lahko znak okužbe, - če dobite izpuščaj ali imate težave z dihanjem (piskanje), ali - če imate kakršne koli prebavne težave.
English: - ciclosporin, tacrolimus, used after a transplant to prevent rejection of transplanted organs, or other immunosuppressants used e.g. to treat psoriasis (a skin disease).
Slovenian: - ciklosporin, takrolimus, ki se uporabljata po presaditvi za preprečitev zavrnitve presajenih organov, ali druga zdravila za zaviranje imunske odzivnosti, ki se uporabljajo, na primer, za zdravljenje psoriaze (kožna bolezen).
English: The desired dose may be withdrawn from the vial by inverting the vial and slowly pulling back on the syringe plunger (figure 3).
Slovenian: Želeni odmerek lahko iz viale odmerite tako, da vialo obrnete in počasi potegnete bat brizge navzdol (slika 3).
English: The recommended dose of mifamurtide for all patients is 2 mg/m body surface area.
Slovenian: Priporočeni odmerek mifamurtida za vse bolnike je 2 mg/m2 telesne površine.
English: Examples include paracetamol for fever, chills and headache and anti-emetics (other than steroids) for nausea and vomiting.
Slovenian: Med njimi so, na primer, paracetamol za zvišano telesno temperaturo, mrzlico in glavobol ter antiemetiki (razen steroidov) za navzeo in bruhanje.
English: Paediatric population < 2 years
Slovenian: Pediatrična populacija, mlajša od 2 let
English: Embryotoxic effects were observed only at maternal toxic levels.
Slovenian: Embriotoksične učinke so opazili samo pri koncentraciji, toksični za mater.
English: It is used in combination with post-operative multi-agent chemotherapy.
Slovenian: Uporablja se v kombinaciji s pooperativno polikemoterapijo.
English: Haemorrhage was observed in animals at very high doses.
Slovenian: Pri živalih so se pri zelo visokih odmerkih pojavile krvavitve.
English: Because mifamurtide acts through stimulation of the immune system, the chronic or routine use of corticosteroids should be avoided during treatment with mifamurtide.
Slovenian: Ker mifamurtid deluje prek stimulacije imunskega sistema, se je med zdravljenjem z mifamurtidom treba izogibati kronični ali rutinski uporabi kortikosteroidov.
English: - Non-steroidal-anti-inflammatory drugs (NSAIDs), such as acetylsalicylic acid, ibuprofen, or diclofenac, used for treatment of headaches, fever or pain.
Slovenian: - nesteroidna protivnetna zdravila (NSAIDs), kot so acetilsalicilna kislina, ibuprofen ali diklofenak, ki se uporabljajo za zdravljenje glavobolov, zvišane telesne temperature ali bolečine.
English: Many of the very commonly reported adverse reactions as shown in the following summary table are thought to be related to the mechanism of action of mifamurtide (see table 1).
Slovenian: Večina zelo pogostih neželenih učinkov, ki so prikazani v spodnji zbirni preglednici, naj bi bila povezana z mehanizmom delovanja mifamurtida (glejte preglednico 1).
English: MEPACT must not be administered as a bolus injection.
Slovenian: Zdravila MEPACT se ne sme uporabljati v obliki bolus injekcije.
English: Data from a six-month dog study of daily intravenous injections of up to 0.5 mg/kg (10 mg/m mifamurtide provide an 8- to 19-fold cumulative exposure safety margin for overt toxicity for the intended clinical dose in humans.
Slovenian: Podatki iz šestmesečne študije pri psih z intravenskimi injekcijami mifamurtida v odmerku do 0,5 mg/kg (10 mg/m2) na dan kažejo 8- do 19-kratno kumulativno varno mejo izpostavljenosti za očitno toksičnost predvidenega kliničnega odmerka pri ljudeh.
English: Store in a refrigerator (2 C-8 °C).
Slovenian: Shranjujte v hladilniku (2 C - 8 °C).
English: Materials required but not provided
Slovenian: Potrebni materiali, ki niso priloženi
English: Liposomal and non-liposomal mifamurtide do not induce the metabolic activity or the transcription of cytochrome P450 in primary cultures of freshly isolated human hepatocytes.
Slovenian: Liposomski in neliposomski mifamurtid ne inducira presnovne aktivnosti ali transkripcije citokroma P450 v primarnih kulturah sveže izoliranih človeških hepatocitov.
English: Not known (cannot be estimated from the available data): - abnormal accumulation of fluid around the heart (pericardial effusion)
Slovenian: Neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov) - nabiranje tekočine v osrčniku (perikardialni izliv)
English: The following events were also observed: haemorrhage and prolongation of coagulation times, infarcts, morphological changes in the wall of small arteries, oedema and congestion of the central nervous system, minor cardiac effects, and slight hyponatraemia.
Slovenian: Opaženi so bili tudi naslednji dogodki: krvavitev in podaljšanje časov strjevanja krvi, infarkti, morfološke spremembe v steni majhnih arterij, edem in kongestija osrednjega živčnega sistema, manjši učinki na srce in blaga hiponatriemija.
English: Frequency category Adverse reaction (preferred term)
Slovenian: Neželeni učinek (prednostni izraz)
English: Therefore, MEPACT should not be used during pregnancy and in women of childbearing potential not using effective contraception.
Slovenian: Zdravilo MEPACT se zato ne sme uporabljati med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo učinkovite kontracepcije.
English: Nausea, vomiting and loss of appetite are very common adverse reactions to mifamurtide (see section 4.8).
Slovenian: Navzea, bruhanje in izguba apetita so zelo pogosti neželeni učinki mifamurtida (glejte poglavje 4.8).
English: It is not known whether MEPACT passes to human milk.
Slovenian: Ni znano, če zdravilo MEPACT prehaja v materino mleko.
English: The use of mifamurtide concurrently with ciclosporin or other calcineurin inhibitors is contraindicated due to their hypothesised effect on splenic macrophages and mononuclear phagocytic function (see section 4.3).
Slovenian: Uporaba mifamurtida skupaj s ciklosporinom ali z drugimi zaviralci kalcinevrina je kontraindicirana zaradi njihovega domnevnega vpliva na makrofage v vranici ali funkcijo mononuklearnih fagocitov (glejte poglavje 4.3).
English: These are typically mild to moderate, transient in nature and generally respond to palliative treatment (e.g., paracetamol for fever).
Slovenian: Navadno so blage do zmerne, prehodne narave in se na splošno odzivajo na paliativno zdravljenje (npr. paracetamol za zvišano telesno temperaturo).
English: Based on the prevalence of the disease, children and young adults were studied in the pivotal trial.
Slovenian: Otroke in mlajše odrasle so na podlagi razširjenosti bolezni proučevali v ključnem preskušanju.
English: What MEPACT is and what it is used for What you need to know before you use MEPACT How to use MEPACT
Slovenian: Kaj je zdravilo MEPACT in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo MEPACT Kako uporabljati zdravilo MEPACT Možni neželeni učinki