FrancophonIA/ELRC3.0 huggingface dataset:
English: PHARMACEUTICAL FORM Round single-scored tablets
Slovenian: FARMACEVTSKA OBLIKA Okrogle tablete z zarezo na eni strani.
English: STATEMENT OF THE MRLs Not applicable.
Slovenian: D. NAVEDBA NAJVIŠJIH DOVOLJENIH KOLIČIN ZAOSTANKOV ZDRAVILA (MRL) Ni smiselno.
English: ANNEX II A. <MANUFACTURER(S) OF THE BIOLOGICAL ACTIVE SUBSTANCE(S) AND> MANUFACTURING AUTHORISATION HOLDER(S) RESPONSIBLE FOR BATCH RELEASE
Slovenian: IZDELOVALEC(IZDELOVALCI) BIOLOŠKE ZDRAVILNE UČINKOVINE (ZDRAVILNIH UČINKOVIN) IN IMETNIK(I) DOVOLJENJ(A) ZA IZDELAVO ZDRAVILA, ODGOVOREN(ODGOVORNI) ZA SPROŠČANJE SERIJE
English: 6 PHARMACEUTICAL PARTICULARS 6.1 List of excipients
Slovenian: 6.1 Seznam pomožnih snovi
English: If treatment is successful, lower the dose to half a tablet a day.
Slovenian: Če je učinkovito, odmerek zmanjšamo na polovico tablete na dan.
English: MINIMUM PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGE BLISTER
Slovenian: PODATKI, KI MORAJO BITI NAVEDENI NA STIČNI OVOJNINI PRETISNI OMOT
English: If treatment is successful lower the dose to half a tablet a day.
Slovenian: Če je zdravljenje s tem odmerkom učinkovito, ga zmanjšamo na polovico tablete na dan.
English: 1 mg/tablet
Slovenian: INCURIN 1 mg, tableta
English: Because of its short acting action, oestriol does not induce bone marrow suppression in the dog.
Slovenian: Zaradi kratkotrajnega delovanja estriol pri psicah ne povzroča supresije kostnega mozga.
English: In case of oestrogenic effects, the dose should be lowered.
Slovenian: Posebni previdnostni ukrepi za uporabo pri živalih Če se pojavijo estrogeni učinki, moramo zmanjšati odmerek.
English: BATCH NUMBER Batch number.
Slovenian: ŠTEVILKA SERIJE Številka serije
English: OTHER INFORMATION Each push-through strip contains 30 tablets.
Slovenian: Pretisni trak vsebuje 30 tablet.
English: To be supplied only on veterinary prescription
Slovenian: Na veterinarski recept.
English: Treatment of hormone-dependent urinary incontinence due to sphincter mechanism incompetence in female dogs.
Slovenian: Zdravljenje hormonsko odvisne urinske inkontinence, ki je posledica nepravilnega delovanja sfinkterskega mehanizma pri psicah
English: Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg.
Slovenian: Po dajanju velikega odmerka, po 2 mg, so zasledili blage, estrogene učinke, kot so nabrekanje zunanjih spolovil, nabrekanje mlečnih žlez ali privlačnost za samca.
English: Pack size: carton box with 1 blister
Slovenian: Velikost pakiranja: škatla z enim pretisnim omotom.
English: THE WORDS “KEEP OUT OF THE REACH AND SIGHT OF CHILDREN” Keep out of the reach and sight of children.
Slovenian: BESEDILO ''ZDRAVILO SHRANJUJTE NEDOSEGLJIVO OTROKOM'' Zdravilo shranjujte nedosegljivo otrokom.
English: Because of its short-acting oestrogenic properties, Incurin does not induce bone marrow suppression in the dog.
Slovenian: Incurin zaradi kratkotrajnega estrogenega učinka pri psicah ne povzroča supresije kostnega mozga.
English: Oestrogenic effects such as swollen vulva, swollen mammary glands and/or attractiveness to males and vomiting have been observed at the highest recommended dose of 2 mg per dog.
Slovenian: Po dajanju največjega priporočenega odmerka, ki je 2 mg na psico, so zasledili estrogene učinke, kot so nabrekla zunanja spolovila, nabrekle mlečne žleze ali privlačnost za samca, in bljuvanje.
English: Upon oral administration a steady state is reached after the second treatment day and no accumulation occurs after multiple dosing.
Slovenian: Pri peroralnem dajanju se ravnovesno stanje vzpostavi po dveh dneh zdravljenja.
English: D. STATEMENT OF THE MRLs
Slovenian: NAVEDBA NAJVIŠJIH DOVOLJENIH KOLIČIN OSTANKOV ZDRAVILA ( MRL)
English: The dose you will receive is decided by your doctor.
Slovenian: Odmerek, ki ga boste prejeli, bo določil vaš zdravnik.
English: Haematological monitoring is thus necessary.
Slovenian: Zato je potrebno hematološko spremljanje.
English: This substance belongs to a group of medicines which protect the heart (cardioprotective medicines).
Slovenian: Ta snov sodi v skupino zdravil, ki ščitijo srce (kardioprotektivna zdravila).
English: If any of the above apply, you must not be given this medicine.
Slovenian: Če karkoli od navedenega velja za vas, ne smete prejeti tega zdravila.
English: There is no specific antidote and symptomatic treatment should be provided.
Slovenian: Specifičnega antidota ni in treba je poskrbeti za simptomatsko zdravljenje.
English: The plasma concentrations declined thereafter with an average half-life value of 2.2 ± 1.2 hours.
Slovenian: Koncentracija v plazmi se je nato zniževala s povprečnim razpolovnim časom 2,2 ± 1,2 ure.
English: The difference was not statistically significant and no consistent cause was apparent, however a contribution of dexrazoxane to the difference cannot be ruled out.
Slovenian: Razlika ni bila statistično pomembna in zanjo ni bilo mogoče odkriti enotnega vzroka, vendar vpletenosti deksrazoksana v nastanek te razlike ni mogoče izključiti.
English: If you get any of the above, tell your doctor straight away or go to the nearest emergency unit.
Slovenian: Če opazite karkoli od navedenega, takoj obvestite zdravnika ali pa pojdite na najbližji urgentni oddelek.
English: Method of administration Intravenous use.
Slovenian: Način uporabe Intravenska uporaba.
English: • Of these 76% were treated for breast cancer and 24% for a variety of advanced cancers.
Slovenian: • med njimi se jih je 76 % zdravilo zaradi raka dojke, 24 % pa zaradi napredovale oblike različnih drugih vrst raka,
English: The majority of controlled clinical studies were performed in patients with advanced breast cancer.
Slovenian: Večino kontroliranih kliničnih študij so izvajali pri bolnikih z napredovalim rakom dojke.
English: You may experience some of the side effects listed in section 4, “Possible side effects”.
Slovenian: Lahko pride do nekaterih neželenih učinkov, ki so našteti v poglavju 4 “Možni neželeni učinki”.
English: Patients receiving chemotherapy alone (n=157)
Slovenian: Bolniki, ki so prejemali samo kemoterapijo (n=157)
English: There are no adequate data from the use of dexrazoxane in pregnant women.
Slovenian: Ustreznih podatkov o uporabi deksrazoksana pri nosečnicah ni.
English: Adverse reactions are ranked under headings of frequency, the most frequent first, using the following convention: very common ( 1/10); common ( 1/100 to  1/10); uncommon ( 1/1,000 to  1/100); not known (cannot be estimated from the available data).
Slovenian: Neželeni učinki so razvrščeni po skupinah glede na pogostost, in sicer od najbolj do najmanj pogostih, pri čemer je uporabljen tale dogovor: zelo pogosti ( 1/10); pogosti ( 1/100 do  1/10); občasni ( 1/1.000 do  1/100); pogostnost neznana (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti).
English: For instructions on reconstitution and dilution of the medicinal product before administration, see section 6.6.
Slovenian: Za navodila glede rekonstitucije in raztapljanja pred apliciranjem zdravila glejte poglavje 6.6.
English: Animal studies showed embryotoxic and teratogenic effects (see section 5.3).
Slovenian: Študije na živalih so pokazale embriotoksično in teratogeno delovanje (glejte poglavje 5.3).
English: An increased risk of the development of second primary malignancies, particularly AML, has been reported.
Slovenian: Poročali so o povečanem tveganju za razvoj drugih primarnih rakov, zlasti AML.
English: How {(Invented) Name} is given to you This medicine is prepared and given to you by your doctor or other medical staff.
Slovenian: Kako boste prejemali zdravilo {(Lastniško) ime} Zdravilo bo pripravil in vam ga dal vaš zdravnik ali kdo drug izmed zdravstvenega osebja.
English: • If you are pregnant or plan to become pregnant (see also “Pregnancy and breast-feeding”).
Slovenian: • če ste noseči ali nameravate zanositi (glejte tudi “Nosečnost in dojenje”),
English: {(Invented) Name} and its metabolites were detected in the plasma and urine of animals and man.
Slovenian: Zdravilo {(Lastniško) ime} in njegove presnovke so zaznali v plazmi in urinu pri živalih in pri ljudeh.
English: A single high dose is better tolerated than the same dose administered several times a day.
Slovenian: Bolniki bolje prenašajo en sam visok odmerek kot pa isti odmerek, razdeljen na več odmerkov preko dneva.
English: The total urinary excretion of unchanged dexrazoxane is in the order of 40%.
Slovenian: Celotno izločanje nespremenjenega deksrazoksana z urinom je reda velikosti 40 %.
English: Therefore if you feel sleepy, do not drive or use machines.
Slovenian: Iz tega razloga ne vozite in ne uporabljajte strojev, če ste zaspani.
English: {(Invented) Name} should not be used during pregnancy unless clearly necessary.
Slovenian: Zdravila{(Lastniško) ime} ne smete uporabljati pri nosečnicah, razen če je to nedvomno potrebno.
English: The apparent volume of distribution is 44.0 ± 3.9 l, suggesting that dexrazoxane distributes mainly in the total body water.
Slovenian: Navidezni volumen porazdelitve je 44,0 ± 3,9 l, kar nakazuje, da se deksrazoksan porazdeli večinoma v celotni telesni vodi.
English: Like all medicines, {(Invented) Name} can have side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo {(Lastniško) ime} neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: • All were treated for breast cancer
Slovenian: • Vsi bolniki so se zdravili zaradi raka dojke.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION [To be completed nationally]
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA [izpolni država članica]
English: Due to the spontaneous nature of post-marketing reporting, such events are listed with frequency “not known” if they were not already identified as reactions from clinical trials.
Slovenian: Ker gre v obdobju trženja zdravila za spontano poročanje, so tovrstni dogodki v preglednici navedeni pod oznako “pogostnost neznana”, če jih niso kot neželene učinke ugotovili že prej v kliničnih preskušanjih.
English: This will start approximately 30 minutes before your cancer treatment (doxorubicin and/or epirubicin).
Slovenian: Zdravilo boste začeli prejemati približno 30 minut pred prejemom zdravil proti raku (doksorubicina in/ali epirubicina).
English: WHAT {(Invented) Name} IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO {LASTNIŠKO IME} IN ZA KAJ GA UPORABLJAMO
English: Data from adults treated in 8 controlled randomised clinical studies have been reviewed, 780 patients received dexrazoxane plus chemotherapy and 789 received chemotherapy alone.
Slovenian: Pregledali so podatke odraslih bolnikov, ki so jih zdravili v 8 kontroliranih randomiziranih kliničnih študijah, 780 bolnikov je prejemalo deksrazoksan in kemoterapijo, 789 pa jih je prejemalo le kemoterapijo.
English: Both dexrazoxane (ICRF-187) and ICRF-198 are capable of chelating metal ions.
Slovenian: Tako deksrazoksan (ICRF-187) kot tudi ICRF-198 lahko kelirata kovinske ione.
English: • If you have or have had liver or kidney problems.
Slovenian: • če imate ali ste imeli kdaj prej težave z jetri ali ledvicami,
English: Effects on CYP450 enzymes or drug transporters have not been studied.
Slovenian: Vpliva na encime CYP450 in transportne proteine niso proučevali.
English: In patients with moderate to severe renal dysfunction (creatinine clearance < 40 ml/min) the dexrazoxane dose should be reduced by 50%.
Slovenian: Pri bolnikih z zmerno do hudo ledvično okvaro (z očistkom kreatinina < 40 ml/min) je treba odmerek deksrazoksana znižati za 50 %.
English: Pharmacotherapeutic group: Detoxifying agents for antineoplastic treatment, ATC code: V03AF02.
Slovenian: Farmakoterapevtska skupina: zdravila za zaščito organizma pred toksičnostjo citostatikov, oznaka ATC: V03AF02.
English: {(Invented) Name} should not be mixed with any other medicinal products during infusion.
Slovenian: Zdravila {(Lastniško) ime} se pri infundiranju ne sme mešati z nobenim drugim zdravilom.
English: Patients should be advised to be cautious when driving or using machines if they experience fatigue during treatment with {(Invented) Name}.
Slovenian: Bolnikom je treba svetovati, naj bodo pri vožnji ali upravljanju s stroji pazljivi, če se med zdravljenjem z zdravilom {(Lastniško) ime} pri njih pojavi utrujenost.
English: Children and adolescents up to 18 years of age (see sections 4.4 and 4.8) Patients who are hypersensitive to dexrazoxane Breast-feeding (see section 4.6)
Slovenian: Otroci in mladostniki do 18. leta starosti (glejte poglavji 4.4 in 4.8) Bolniki, ki so preobčutljivi za deksrazoksan Dojenje (glejte poglavje 4.6)
English: If {(Invented) Name} powder or solution gets on your skin, tell your doctor straight away.
Slovenian: če prašek ali raztopina zdravila {(Lastniško) ime} pride v stik z vašo kožo, takoj povejte svojemu zdravniku.
English: • If you are allergic to dexrazoxane or razoxane.
Slovenian: • če ste alergični na deksrazoksan ali razoksan.
English: Plasma protein binding of dexrazoxane is low (2%) and it does not penetrate into the cerebrospinal fluid to a clinically significant extent.
Slovenian: Deksrazoksan se le v majhni meri veže na proteine v plazmi (v 2 %), v cerebrospinalno tekočino pa ne prehaja v klinično pomembnem obsegu.
English: Your doctor may carry out tests before and during the treatment with {(Invented) Name} to see how well the treatment is working and to check the function of some of your organs, such as your heart, kidneys or liver.
Slovenian: Prav tako morate vedeti, da: boste morali morda pred zdravljenjem z zdravilom {(Lastniško) ime} in med njim opravljati preiskave, da bo vaš zdravnik lahko ocenil učinkovitost zdravljenja in preveril delovanje nekaterih vaših organov, kot so srce, ledvice ali jetra.
English: Second primary malignancies
Slovenian: Drugi primarni raki
English: The majority of the administered dose is eliminated in urine mainly as unchanged dexrazoxane.
Slovenian: Največji del odmerka se izloči z urinom, večinoma v obliki nespremenjenega deksrazoksana.
English: Fertility The effects of {(Invented) Name} on the fertility of humans and animals have not been studied.
Slovenian: Plodnost Vpliva zdravila {(Lastniško) ime} na plodnost pri ljudeh in pri živalih niso proučevali.
English: Use of dexrazoxane in combination with adjuvant breast cancer therapy or chemotherapy intended as curative is therefore not recommended.
Slovenian: Iz tega razloga uporaba deksrazoksana v kombinaciji z adjuvantnim zdravljenjem raka dojke ali s kemoterapijo z namenom zdravljenja ni priporočena.
English: {(Invented) Name} may increase the risk of developing leukaemia (cancer of the blood).
Slovenian: uporaba zdravila {(Lastniško) ime} lahko poveča tveganje za razvoj levkemije (krvnega raka).
English: You will not be given {(Invented) Name} if you are pregnant or had planned to become pregnant, unless your doctor decides it is necessary.
Slovenian: Če ste noseči ali nameravate zanositi, vam ne bodo dali zdravila {(Lastniško) ime}, razen če vaš zdravnik presodi, da je nujno potrebno.
English: The dosage ratio should be kept, i.e. if the anthracycline dose is reduced the dexrazoxane dose should be reduced accordingly.
Slovenian: Pri odmerjanju se je treba držati priporočenega razmerja, kar pomeni, da je treba pri znižanju odmerka antraciklina ustrezno znižati tudi odmerek deksrazoksana.
English: Animal reproduction studies reveal that razoxane is embryotoxic to mice, rats and rabbits and also teratogenic to rats and mice, although a different dosing schedule was used compared to that used in man.
Slovenian: Rezultati študij vpliva na razmnoževanje pri živalih kažejo, da razoksan pri miših, podganah in kuncih deluje embriotoksično, pri podganah in miših pa tudi teratogeno, pri čemer so pri živalih uporabili drugačen razpored odmerjanja kot pri ljudeh.
English: The maximum plasma concentration observed after a 12-15 minute infusion of 1000 mg/m2 is around 80 μg/ml with area under the plasma concentration-time curve (AUC) of 130 ± 15 mg.h/l.
Slovenian: Najvišja koncentracija v plazmi, ki so jo opažali po 12-15-minutni infuziji odmerka 1000 mg/m2, je bila približno 80 μg/ml, pri čemer je bila površina pod krivuljo časovnega poteka koncentracije v plazmi (AUC) 130 ± 15 mg.h/l.
English: Oedema, thirst
Slovenian: občasni edem, žeja
English: The above table shows adverse reactions reported in clinical studies and having a reasonable possibility of a causal relationship with {(Invented) Name}.
Slovenian: V preglednici zgoraj so navedeni neželeni učinki, o katerih so poročali v kliničnih študijah, pri njih pa obstaja razumna možnost vzročne povezanosti z zdravilom {(Lastniško) ime}.
English: PHARMACEUTICAL FORM [To be completed nationally]
Slovenian: FARMACEVTSKA OBLIKA [izpolni država članica]
English: Before you are given {(Invented) Name}, tell your doctor
Slovenian: Preden prejmete zdravilo {(Lastniško) ime}, povejte zdravniku,
English: ANNEX III SUMMARY OF PRODUCT CHARACTERISTICS AND PACKAGE LEAFLET
Slovenian: PRILOGA III POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA IN NAVODILO ZA UPORABO
English: There are no animal studies on the transfer of the active substance and/or its metabolites into milk.
Slovenian: Študij na živalih glede prehajanja zdravilne učinkovine in/ali njenih presnovkov v mleko niso izvajali.
English: The total body clearance of dexrazoxane in adults is estimated at 14.4 ± 1.6 l/h.
Slovenian: Ocenili so, da je pri odraslih celotni očistek izločanja deksrazoksana iz telesa 14,4 ± 1,6 l/h.
English: Management should include prophylaxis and treatment of infections, fluid regulation, and maintenance of nutrition.
Slovenian: Ukrepi naj vključujejo preprečevanje in zdravljenje okužb, uravnavanje telesnih tekočin in ustrezno prehranjevanje bolnika.
English: The possibility that dexrazoxane was a contributing factor to the imbalance cannot be ruled out (see section 5.1).
Slovenian: Možnosti, da je k temu neravnovesju prispevala uporaba deksrazoksana, ni mogoče izključiti (glejte poglavje 5.1).
English: • If you have or have had a heart attack, heart failure, uncontrolled chest pain and heart valve problems.
Slovenian: • če ste preživeli srčni infarkt, če imate ali ste imeli kdaj prej srčno popuščanje, slabo zdravljeno bolečino v prsih ali težave s srčnimi zaklopkami,
English: You or your doctor should immediately rinse the affected area thoroughly with water.
Slovenian: Prizadeti predel kože morate sami ali pa ga mora vaš zdravnik takoj temeljito sprati z vodo.
English: {(Invented) Name} is used to prevent heart damage when medicines called doxorubicin or epirubicin are used during breast cancer treatment in adults.
Slovenian: Zdravilo {(Lastniško) ime} uporabljamo za preprečevanje okvar srca, do katerih pride pri uporabi zdravil z imenom doksorubicin ali epirubicin pri zdravljenju odraslih bolnikov z rakom dojke.
English: {(Invented) Name} is given as a drip (infusion) into a vein over about 15 minutes.
Slovenian: Zdravilo {(Lastniško) ime} boste prejeli v obliki infuzije v veno, kar bo trajalo približno 15 minut.
English: Dexrazoxane, an analogue of EDTA (ethylene diamine tetra-acetic acid), is hydrolysed in cardiac cells to the ring-opened product ICRF-198.
Slovenian: Deksrazoksan, ki je analog EDTA (etilen-diamin-tetraocetne kisline), se v celicah srčne mišice hidrolizira v spojino ICRF-198 z odprtim obročem.
English: Standard cardiac monitoring associated with doxorubicin or epirubicin treatment should be continued.
Slovenian: Običajno spremljanje delovanja srca, ki je potrebno pri zdravljenju z doksorubicinom oziroma epirubicinom, je treba izvajati še naprej.
English: How to store {(Invented) Name} Further information
Slovenian: Shranjevanje zdravila {(Lastniško) ime} Dodatne informacije
English: {(Invented) Name} is administered together with anthracycline chemotherapy and, consequently, the relative contributions of anthracycline and {(Invented) Name} to the adverse reaction profile may be unclear.
Slovenian: Zdravilo {(Lastniško) ime} se daje skupaj s kemoterapevtikom antraciklinom, zato sta posledično relativna prispevka antraciklina in zdravila {(Lastniško) ime} k profilu neželenih učinkov lahko nejasna.
English: It is generally thought that they can provide cardioprotection by scavenging metal ions thus preventing the Fe3+-anthracycline complex from redox cycling and forming reactive radicals.
Slovenian: Prevladuje domneva, da obe spojini ščitita srčno mišico tako, da odstranjujeta kovinske ione in s tem preprečujeta redoks kroženje pri kompleksih antraciklinov s Fe3+, pri čemer bi nastajali reaktivni radikali.
English: The exact mechanism by which dexrazoxane exerts its cardioprotective effect has not been fully elucidated, however based on the available evidence the following mechanism has been suggested.
Slovenian: Mehanizem delovanja, s katerim deksrazoksan ščiti srce, še ni natančno pojasnjen, na podlagi zbranih dokazov pa domnevajo, da gre za mehanizem, ki je opisan v nadaljevanju.
English: Men should continue using contraception for at least three months after {(Invented) Name} treatment has been stopped (see also “Pregnancy and breast-feeding”).
Slovenian: Moški morajo z uporabo kontracepcije nadaljevati še najmanj tri mesece po prekinitvi zdravljenja z zdravilom {(Lastniško) ime} (glejte tudi “Nosečnost in dojenje”).
English: The combination of {(Invented) Name} with your cancer treatment may increase the risk of blood clots.
Slovenian: uporaba zdravila {(Lastniško) ime} v kombinaciji z zdravili proti raku lahko poveča tveganje za nastanek krvnih strdkov.
English: There are no data that support the use of dexrazoxane in patients with myocardial infarction within the past 12 months, pre-existing heart failure (including clinical heart failure secondary to anthracycline treatment), uncontrolled angina or symptomatic valvular heart disease.
Slovenian: Nobeni podatki ne govorijo v prid uporabi deksrazoksana pri bolnikih, ki so v zadnjih 12 mesecih preživeli miokardni infarkt, pri tistih z že prisotnim srčnim popuščanjem (kar vključuje klinično srčno popuščanje zaradi zdravljenja z antraciklini), z neurejeno angino pektoris ali s simptomatsko boleznijo srčnih zaklopk.
English: Other toxic effects were malaise, low grade fever, increased urinary clearance of iron and zinc, anaemia, abnormal blood clotting, transient elevation of serum triglyceride and amylase levels, and a transient decrease in serum calcium level.
Slovenian: Drugi škodljivi učinki so vključevali splošno slabo počutje, nekoliko zvišano telesno temperaturo, povečano izločanje železa in cinka z urinom, anemijo, motnje strjevanja krvi, prehodno zvišanje ravni trigliceridov in amilaze v serumu ter prehodno znižanje ravni kalcija v serumu.
English: It is unknown whether dexrazoxane and/or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se deksrazoksan in/ali njegovi presnovki izločajo v materino mleko.
English: Dexrazoxane's maximum tolerated dose (MTD) when given as monotherapy by short infusion every three weeks for cardioprotection has not been specifically studied.
Slovenian: Varnostne lastnosti pri najvišjem prenosljivem odmerku (MTD - maximum tolerated dose) Najvišjega prenosljivega odmerka (MTD) deksrazoksana za zaščito srca v monoterapiji s kratko infuzijo vsake tri tedne niso posebej proučevali.
English: There is limited data on pharmacokinetic interactions with chemotherapeutic agents other than doxorubicin, epirubicin, cyclophosphamide, 5-fluorouracil and paclitaxel.
Slovenian: Na voljo je le malo podatkov o farmakokinetičnih interakcijah z drugimi kemoterapevtiki, pri čemer so doksorubicin, epirubicin, ciklofosfamid, 5-fluorouracil in paklitaksel izvzeti.
English: At higher doses of chemotherapy, where the {(Invented) Name} dose exceeds 1000 mg/m2, myelosuppression may increase significantly.
Slovenian: Pri višjih odmerkih kemoterapevtikov, pri katerih odmerki zdravila {(Lastniško) ime} presegajo 1000 mg/m2, lahko postane zaviranje delovanja kostnega mozga zelo izrazito.