FrancophonIA/ELRC3.0 huggingface dataset:
English: • triazolam and midazolam (taken by mouth) - to help you sleep or for anxiety
Croatian: • triazolam i midazolam (primijenjeni kroz usta) - koriste se kao pomoć kod tegoba sa spavanjem ili za ublažavanje tjeskobe
English: There was no evidence that age and body-weight explained the gender difference in this study.
Croatian: Nije bilo dokaza da dob i tjelesna masa u ovom ispitivanju objašnjavaju razlike s obzirom na spol.
English: It is a member of a class of medicines called protease inhibitors.
Croatian: Pripada skupini lijekova koji se zovu inhibitori proteaze.
English: On rare occasions these muscle disorders have been serious (rhabdomyolysis).
Croatian: U rijetkim slučajevima ti su se mišićni poremećaji pokazali ozbiljnima (rabdomioliza).
English: Key: ↓ reduced, ↑ increased, ↔ unchanged, ↑↑ markedly increased
Croatian: Ključ: ↓ sniženo, ↑ povišeno, ↔ nepromijenjeno, ↑↑ značajno povišeno
English: *Historical data from the thorough QT study conducted in healthy volunteers
Croatian: *Podaci iz prethodnog sveobuhvatnog ispitivanja QT-intervala koje je provedeno u zdravih dobrovoljaca.
English: This is partly linked to restored health and lifestyle, and in the case of blood lipids sometimes to the HIV medicines themselves.
Croatian: To je djelomično povezano s poboljšanjem zdravlja i životnog stila, a u slučaju lipida u krvi ponekad s lijekovima za HIV.
English: MARKETING AUTHORISATION NUMBER EU/1/96/026/002
Croatian: BROJ ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/96/026/002
English: Antiarrhythmics Bepridil
Croatian: Antiaritmici Bepridil
English: Limited data from controlled clinical studies with the approved dosage regimen do not indicate a major difference in the efficacy and safety profile between men and women.
Croatian: Ograničeni podaci iz kontroliranih kliničkih ispitivanja s odobrenim režimom doziranja ne upućuju na veće razlike u djelotvornosti i sigurnosnom profilu između muškaraca i žena.
English: The mean residence time of saquinavir was 7 hours (n = 8).
Croatian: Prosječno vrijeme zaostajanja sakvinavira iznosi 7 sati (n=8).
English: The serum concentration of digoxin should be monitored and a dose reduction of digoxin should be considered if necessary.
Croatian: Treba pratiti serumske koncentracije digoksina i po potrebi razmotriti smanjenje doze digoksina.
English: The frequency groupings according to MedDRA convention are: Very common (≥ 1/10); common (≥ 1/100 to <1/10); uncommon (≥ 1/1,000 to <1/100); rare (≥ 1/10,000 to <1/1,000); very rare (<1/10,000); not known (frequency cannot be estimated from the available data).
Croatian: Kategorije učestalosti prema MedDRA klasifikaciji su sljedeće: vrlo često (≥ 1/10); često (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000); nepoznato (učestalost se ne može procijeniti iz dostupnih podataka).
English: This is the approved combination regimen.
Croatian: Ovo je odobreni režim kombinirane terapije.
English: # ITT/e = Intent-to-treat/exposed † Data from clinical study report ‡ Data from MaxCmin1 publication
Croatian: # ITT/e = predviđeni za liječenje/izloženi † podaci iz izvješća o kliničkom ispitivanju ‡ podaci iz publikacije o MaxCmin1
English: On Day 3 of dosing, ECG measurements were done over a period of 20 hours.
Croatian: Trećeg dana doziranja provedeno je mjerenje EKG-a u trajanju od 20 sati.
English: It is believed that these symptoms are due to an improvement in the body's immune response, enabling the body to fight infections that may have been present with no obvious symptoms.
Croatian: Smatra se da su ti simptomi posljedica poboljšanog imunološkog odgovora kojim se tijelo bori protiv infekcija koje su možda bile prisutne bez vidljivih simptoma.
English: In combination with ritonavir
Croatian: U kombinaciji s ritonavirom
English: Methadone AUC ↓ 19 % (90 % CI 9 % to 29 %) None of the 12 patients experienced withdrawal symptoms.
Croatian: Metadon AUC ↓ 19% (90% CI 9% to 29%) Nijedan od 12 bolesnika nije imao simptome ustezanja.
English: Use with caution due to possible cardiac arrhythmias.
Croatian: Primjenjivati uz oprez zbog mogućih srčanih aritmija.
English: Maraviroc Cmax: ↑ 3.78
Croatian: Maravirok Cmax: ↑ 3,78
English: Sixteen of 18 children could not swallow Invirase hard capsules and received medication by opening the capsules and mixing the contents with different vehicles.
Croatian: Šesnaestoro od 18 djece nije moglo progutati lijek Invirase tvrde kapsule te su lijek uzimali tako da se kapsula otvorila i sadržaj pomiješao s različitim otopinama.
English: PHARMACEUTICAL FORM AND CONTENTS 120 film-coated tablets
Croatian: OBLIK I SADRŽAJ 120 filmom obloženih tableta
English: Mechanism of action: The HIV protease is an essential viral enzyme required for the specific cleavage of viral gag and gag-pol polyproteins.
Croatian: Mehanizam djelovanja: HIV proteaza je neophodan virusni enzim, potreban za specifično cijepanje virusnih poliproteina gag i gag-pol.
English: The corresponding values in the control group were 28.5 (71%) µg·hr/ml and 4.3 (68%) µg/ml.
Croatian: Odgovarajuće vrijednosti u kontrolnoj skupini bile su 28,5 (71%) µg•hr/ml i 4,3 (68%) µg/ml.
English: Adults over 60 years: The experience with Invirase in adults over 60 years is limited.
Croatian: Odrasli stariji od 60 godina: Iskustvo s primjenom lijeka Invirase u odraslih osoba starijih od 60 godina je ograničeno.
English: • Clinical Management:
Croatian: • Kliničko zbrinjavanje:
English: Alprazolam Clorazepate Diazepam
Croatian: Alprazolam Klorazepat Diazepam
English: Saquinavir ↑
Croatian: Sakvinavir ↑
English: This can happen especially if you are female or elderly.
Croatian: Ta se pojava javlja osobito u osoba ženskog spola ili starije dobi.
English: An updated RMP should be submitted: - At the request of the European Medicines Agency; - Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: Ažurirani RMP treba dostaviti: - Na zahtjev Europske agencije za lijekove; - Prilikom svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: The drugs listed above might cause serious side effects if you take them together with Invirase.
Croatian: Gore navedeni lijekovi mogu uzrokovati ozbiljne nuspojave ako ih uzimate zajedno s lijekom Invirase.
English: If you are taking an oral contraceptive to prevent pregnancy, you should use an additional or different type of contraception since ritonavir may reduce the effectiveness of oral contraceptives.
Croatian: Ako uzimate neki oralni kontraceptiv za zaštitu od trudnoće, morate koristiti dodatnu ili drugu metodu kontracepcije jer ritonavir može umanjiti djelotvornost oralnih kontraceptiva.
English: The low bioavailability is thought to be due to a combination of incomplete absorption and extensive firstpass metabolism.
Croatian: Smatra se da je niska bioraspoloživost uzrokovana kombinacijom nepotpune apsorpcije i ekstenzivnog metabolizma prvog prolaza.
English: Invirase is contraindicated in patients with:
Croatian: Invirase je kontraindiciran u bolesnika:
English: UNIQUE IDENTIFIER - 2D BARCODE Not applicable
Croatian: 17. JEDINSTVENI IDENTIFIKATOR - 2D BARKOD Nije primjenjivo
English: • certain medicines used to prevent rejection of new organs after a transplant operation such as tacrolimus
Croatian: • nekih lijekova koji se koriste za sprječavanje odbacivanja novih organa nakon operacije presađivanja, poput takrolimusa
English: Caution is warranted and clinical monitoring of patients is recommended.
Croatian: Savjetuje se oprez i preporučuje klinički nadzor bolesnika.
English: If you are not sure, talk to your doctor or pharmacist before taking Invirase.
Croatian: Ako niste sigurno, razgovarajte s liječnikom ili ljekarnikom prije nego počnete uzimati Invirase.
English: Haemophiliac patients should therefore be made aware of the possibility of increased bleeding.
Croatian: Bolesnike s hemofilijom stoga treba upozoriti na mogućnost pojačanog krvarenja.
English: Fluticasone propionate ↑ Intrinsic cortisol ↓ 86% (90% CI 82%-89%) Greater effects may be expected when fluticasone propionate is inhaled.
Croatian: Flutikazonpropionat ↑ Intrinzični kortizol ↓ 86% (90% CI 82%-89%) Mogu se očekivati veći učinci ako se flutikazonpropionat inhalira.
English: - Physicians should enquire about any known familial history of sudden death at a young age as this may be suggestive of congenital QT prolongation.
Croatian: - Liječnici se moraju raspitati o poznatim slučajevima iznenadne smrti u mlađoj dobi u obiteljskoj anamnezi jer to može upućivati na urođeno produljenje QT-intervala.
English: INFORMATION IN BRAILLE invirase 500 mg
Croatian: 16. PODACI NA BRAILLEOVOM PISMU invirase 500 mg
English: Combination not recommended.
Croatian: Ova kombinacija se ne preporučuje.
English: Interaction unknown.
Croatian: Interakcija nije poznata.
English: INR (international normalised ratio) monitoring recommended.
Croatian: Preporučuje se praćenje INR-a (međunarodnog normaliziranog omjera).
English: These events were vomiting (3 patients), abdominal pain (1 patient) and diarrhoea (1 patient).
Croatian: Ti su događaji bili povraćanje (3 bolesnika), bol u abdomenu (1 bolesnik) i proljev (1 bolesnik).
English: If you stop taking Invirase
Croatian: Ako prestanete uzimati Invirase
English: If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered.
Croatian: Primijete li se znakovi pogoršanja bolesti jetre u tih bolesnika, mora se razmotriti privremen ili trajan prekid liječenja.
English: In this situation a reduced dose of atorvastatin should be considered.
Croatian: U toj situaciji treba razmotriti sniženje doze atorvastatina.
English: It has been shown that saquinavir is approximately 97 % bound to plasma proteins up to 30 µg/ml.
Croatian: Dokazano je da se približno 97% sakvinavira veže na proteine plazme u količini do 30 µg/ml.
English: If signs or symptoms suggesting cardiac arrhythmia occur, continuous monitoring of ECG should be performed.
Croatian: Ako nastupe znakovi ili simptomi koji ukazuju na srčanu aritmiju, treba kontinuirano kontrolirati EKG.
English: The presence of 3 or more mutations was associated with reduced response to saquinavir/ritonavir.
Croatian: Prisutnost tri ili više mutacija povezana je sa smanjenim odgovorom na sakvinavir/ritonavir.
English: - Each patient (or patient's caregiver) should be reminded to read the Package Leaflet included in the Invirase Package.
Croatian: - Svakom bolesniku (ili njegovatelju bolesnika) treba napomenuti da pročita uputu o lijeku priloženu u pakiranju lijeka Invirase.
English: No pharmacokinetic interaction studies have been completed.
Croatian: Nije dovršeno niti jedno ispitivanje farmakokinetičkih interakcija.
English: If concomitant use is deemed necessary because the potential benefit to the patient outweighs the risk, particular caution is warranted (see section 4.4; for information on individual drugs, see Table 1).
Croatian: Ako se istodobna primjena smatra potrebnom jer moguća korist liječenja nadilazi rizike, savjetuje se poseban oprez (vidjeti dio 4.4; za informacije o pojedinim lijekovima, vidjeti Tablicu 1).
English: Maraviroc AUC12 ↑ 8.77
Croatian: Maravirok AUC12 ↑ 8,77
English: Do not take Invirase with any other drug unless you have talked to your doctor first.
Croatian: Nemojte uzimati Invirase ni s jednim drugim lijekom ako o tome prethodno niste razgovarali sa svojim liječnikom.
English: Higher doses of ritonavir have been shown to be associated with an increased incidence of adverse events.
Croatian: Pokazalo se da su više doze ritonavira povezane s povećanom incidencijom štetnih događaja.
English: Pharmaco-therapeutic group: Antiviral agent, ATC code J05A E01
Croatian: Farmakoterapijska skupina: Antivirusni lijekovi, ATK oznaka: J05A E01
English: Vasodilators (peripheral) Vincamine i.v.
Croatian: Vazodilatatori (periferni) Vinkamin i.v.
English: 6.5 Nature and contents of container Plastic bottles (HDPE) containing 120 tablets.
Croatian: 6.5 Vrsta i sadržaj spremnika Plastične boce (HDPE) koje sadrže 120 tableta.
English: • hypersensitivity to the active substance or to any of the excipients listed in section 6.1
Croatian: • preosjetljivih na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 6.1
English: Medicinal product by therapeutic area (dose of Invirase used in study)
Croatian: Lijekovi po terapijskim područjima (doza lijeka Invirase korištena u ispitivanju)
English: No unexpected adverse events were observed in this study.
Croatian: U tom ispitivanju nisu opaženi drugi štetni događaji.
English: High doses of ketoconazole (> 200 mg/day) are not recommended.
Croatian: Više doze ketokonazola (> 200 mg/dan) se ne preporučuju.
English: Lopinavir ↔ (based on historical comparison with unboosted lopinavir)
Croatian: Lopinavir ↔ (na temelju povijesne usporedbe s nepojačanim lopinavirom)
English: Lidocaine (systemic) Quinidine
Croatian: Lidokain (sistemski) Kinidin
English: Considerations when initiating Invirase therapy: Invirase should not be given as the sole protease inhibitor.
Croatian: Na što treba paziti prilikom uvođenja terapije lijekom Invirase: Invirase se ne smije primjenjivati kao jedini inhibitor proteaze.
English: • Take Invirase at the same time as your ritonavir (Norvir) capsules.
Croatian: • Uzmite Invirase u isto vrijeme kad i kapsule ritonavira (Norvir).
English: Invirase contains lactose
Croatian: Invirase sadrži laktozu
English: While the supra-therapeutic dose of Invirase/ritonavir appeared to have a greater effect on the QT interval than the therapeutic dose of Invirase/ritonavir, it is not sure if maximum effect for both doses has been observed.
Croatian: Iako se čini da je supraterapijska doza lijekova Invirase/ritonavir imala veći učinak na QT-interval od terapijske doze lijekova Invirase/ritonavir, nije sigurno je li opažen najveći učinak obje doze.
English: The inducing effect of St. John's wort may persist for at least 2 weeks after cessation of treatment.
Croatian: Inducirajući učinak gospine trave može potrajati najmanje dva tjedna nakon prestanka primjene.
English: At present, there is only limited information on the use of Invirase/ritonavir in children and in adults over the age of 60 years.
Croatian: Trenutno su dostupni tek ograničeni podaci o primjeni lijekova Invirase/ritonavir u djece mlađe od 18 i odraslih starijih od 60 godina.
English: Invirase does not require any special storage conditions.
Croatian: Invirase ne zahtijeva posebne uvjete čuvanja.
English: Use of unboosted saquinavir with zalcitabine and/or zidovudine has been studied in adults.
Croatian: - Primjena nepojačanog sakvinavira zajedno sa zalcitabinom i/ili zidovudinom ispitivala se u odraslih osoba.
English: Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Croatian: Znakovi osteonekroze su ukočenost zglobova, bolovi u zglobovima (osobito u kuku, koljenu i ramenu) i poteškoće pri kretanju.
English: Treatment of overdose with saquinavir should consist of general supportive measures, including monitoring of vital signs and ECG, and observations of the patient's clinical status.
Croatian: Liječenje predoziranja sakvinavirom treba obuhvatiti opće potporne mjere, uključujući nadzor vitalnih znakova i EKG-a te praćenje kliničkog statusa bolesnika.
English: The film-coated tablets should be swallowed whole Read the package leaflet before use
Croatian: Filmom obložene tablete treba progutati cijele Prije uporabe pročitajte uputu o lijeku
English: Invirase/ritonavir may be taken with a number of other medications that are commonly used in HIV infection.
Croatian: Invirase/ritonavir mogu se uzimati s nizom drugih lijekova koji se uobičajeno koriste za liječenje HIV infekcije.
English: Acute and chronic toxicity: Saquinavir was well tolerated in oral acute and chronic toxicity studies in mice, rats, dogs and marmosets.
Croatian: Akutna i kronična toksičnost: Sakvinavir se dobro podnosio u istraživanjima akutne i kronične toksičnosti pri oralnoj primjeni na miševima, štakorima, psima i marmoset majmunima.
English: Therefore, before taking this medicine, you should have told your doctor if you suffer from diarrhoea, or if you have allergies (see Section 4) or if you have an intolerance to some sugars (see section “Invirase contains lactose”).
Croatian: Stoga prije uzimanja ovog lijeka morate reći liječniku ako imate proljev ili alergije (vidjeti dio 4) ili ne podnosite neke šećere (vidjeti odlomak “Invirase sadrži laktozu”).
English: There are some medications that must not be taken with Invirase/ritonavir (see section "Do not take Invirase if you are taking any of the following medicines:" above).
Croatian: Postoje neki lijekovi koji se ne smiju uzimati s lijekovima Invirase/ritonavir (vidjeti odlomak "Nemojte uzimati Invirase ako uzimate neki od sljedećih lijekova:" gore).
English: It is for the treatment of infection with the human immunodeficiency virus (HIV).
Croatian: Namijenjen je za liječenje zaraze virusom humane imunodeficijencije (HIV).
English: Results are based on total concentrations (protein-bound and unbound).
Croatian: Rezultati se temelje na ukupnim koncentracijama sakvinavira (vezanog za proteine i slobodnog).
English: Pregnancy: Evaluation of experimental animal studies does not indicate direct or indirect harmful effects with respect to the development of the embryo or foetus, the course of gestation and peri- and post-natal development.
Croatian: Trudnoća: Analiza eksperimentalnih istraživanja na životinjama ne upućuje na izravne ni neizravne štetne učinke na razvoj embrija i fetusa, tijek gestacije te perinatalni i postnatalni razvoj.
English: Interaction with zalcitabine is unlikely due to different routes of metabolism and excretion.
Croatian: - Interakcija sa zalcitabinom nije vjerojatna zbog različitih putova metaboliziranja i izlučivanja.
English: The CD4 lymphocyte count expressed as percentage mean CD4 increased by a mean of 2.97% over the same 48 week period.
Croatian: Broj CD4 limfocita (izražen kao prosječni postotak CD4 stanica) povećao se za prosječno 2,97% u istom 48-tjednom razdoblju.
English: If you have taken more than the prescribed dose of Invirase/ritonavir you must contact your doctor or pharmacist.
Croatian: Ako ste uzeli veću dozu lijekova Invirase/ritonavir od propisane, morate se javiti svom liječniku ili ljekarniku.
English: HMG-CoA reductase inhibitors Pravastatin
Croatian: Inhibitori HMG-KoA reduktaze Pravastatin
English: Events of syncope/presyncope occurred at a higher than expected rate and were seen more frequently under treatment with saquinavir (11 of 13).
Croatian: Slučajevi sinkope/presinkope nastupili su u većem postotku nego što se očekivalo i bili su češći kod liječenja sakvinavirom (11 od 13).
English: Other medicines and Invirase Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzimali ili biste mogli uzeti bilo koje druge lijekove.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA Not applicable
Croatian: JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM Nije primjenjivo
English: Race (White/Black/Asian) % 86/9/1 Age, median, yrs
Croatian: Rasa (Bijelci, Crnci, Azijati) % 86/9/1 Dob (medijan, godina) Kategorija C (%) po CDC klasifikaciji
English: • clinically relevant heart failure with reduced left-ventricular ejection fraction
Croatian: • s klinički značajnim zatajenjem srca sa smanjenom ejekcijskom frakcijom lijeve klijetke
English: Therefore, medicinal products that either share this metabolic pathway or modify CYP3A4 and/or P-gp activity (see "Other potential interactions") may modify the pharmacokinetics of saquinavir.
Croatian: Stoga lijekovi koji dijele taj metabolički put ili modificiraju djelovanje CYP3A4 i/ili P-glikoproteina (vidjeti "Druge moguće interakcije") mogu promijeniti farmakokinetiku sakvinavira.
English: Upper 95%-CI of ddQTcS
Croatian: Gornja granica 95%-tnog CI za ddQTcS
English: • Take your Invirase film-coated tablets with or after food.
Croatian: • Uzmite Invirase filmom obložene tablete uz obrok ili nakon njega.
English: • simvastatin and lovastatin - for lowering blood cholesterol
Croatian: • simvastatin i lovastatin - koriste se za snižavanje kolesterola u krvi
English: Medicines that can interact with saquinavir or ritonavir include:
Croatian: Lijekovi koji mogu uzajamno djelovati sa sakvinavirom ili ritonavirom uključuju:
English: • If you are taking any medicine that decreases your blood potassium levels talk to your doctor before taking Invirase.
Croatian: • Ako uzimate neki lijek koji snižava razinu kalija u krvi, porazgovarajte sa svojim liječnikom prije uzimanja lijeka Invirase.
English: Standard dose
Croatian: Standardna doza
English: Therapy with Invirase should be initiated by a physician experienced in the management of HIV infection.
Croatian: Liječenje lijekom Invirase mora započeti liječnik s iskustvom u liječenju HIV infekcije.
English: If you forget to take Invirase
Croatian: Ako ste zaboravili uzeti Invirase
English: • electrolyte disturbances, particularly uncorrected hypokalaemia
Croatian: • s poremećajem ravnoteže elektrolita, osobito neliječenom hipokalijemijom
English: * Saquinavir Mutation Score Mutations: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I, I62V, G73S/T, V82A/F/S/T, I84V, L90M
Croatian: * Mutacije povezane sa sakvinavirom: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I, I62V, G73S/T, V82A/F/S/T, I84V i L90M
English: • medicines for gout, such as colchicine
Croatian: • lijekove za giht, poput kolhicina
English: A causal relationship has been evoked, although the mechanism of action has not been elucidated.
Croatian: Pretpostavlja se da postoji uzročna povezanost iako mehanizam djelovanja nije utvrđen.
English: If Invirase is co-administered with parenteral midazolam it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Croatian: Ako se Invirase daje istodobno s parenteralno primijenjenim midazolamom, to se mora odvijati u jedinicama intenzivne skrbi ili sličnom okruženju u kojem se može osigurati poman klinički nadzor i odgovarajuća medicinska skrb u slučaju respiratorne depresije i/ili produljene sedacije.
English: • quetiapine - used to treat schizophrenia, bipolar disorder and major depressive disorder
Croatian: • kvetiapin - koristi se za liječenje shizofrenije, bipolarnog poremećaja i velikog depresivnog poremećaja
English: Excipient with known effect: Lactose monohydrate: 38.5 mg.
Croatian: Pomoćna tvar s poznatim učinkom: laktoza hidrat: 38,5 mg.
English: • clinically relevant bradycardia
Croatian: • s klinički značajnom bradikardijom
English: Patients on saquinavir treatment must not take garlic capsules due to the risk of decreased plasma concentrations and loss of virological response and possible resistance to one or more components of the antiretroviral regimen.
Croatian: - Bolesnici koji se liječe sakvinavirom ne smiju uzimati kapsule češnjaka zbog opasnosti od sniženja koncentracije lijeka u plazmi i gubitka virološkog odgovora te moguće otpornosti na jednu ili više komponenata antiretrovirusne terapije.
English: In case of withdrawal of glucocorticoids progressive dose reduction may have to be performed over a longer period.
Croatian: U slučaju prekida primjene glukokortikoida možda će biti potrebno progresivno smanjivanje doze tijekom duljeg razdoblja.