FrancophonIA/ELRC3.0 huggingface dataset:
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Slovenian: Zahteve glede predložitve rednega posodobljenega poročila o varnosti zdravila za to zdravilo so določene v seznamu referenčnih datumov Unije (seznamu EURD), opredeljenem v členu 107c(7)
English: Polyvinylchloride (PVC), polyethylene (PE), and polychlorotrifluoroethylene (PCTFE) blister sealed with an aluminium foil.
Slovenian: Pretisni omot iz polivinilklorida (PVC), polietilena (PE) in poliklorotrifluoroetilena (PCTFE), zaprt z aluminijasto folijo.
English: Moderate liver disease (Child Pugh Class B) affected the pharmacokinetics of duloxetine.
Slovenian: Zmerno okvarjeno delovanje jeter (razred Child Pugh B) je vplivalo na farmakokinetiko duloksetina.
English: However, as with any medicine, caution should be exercised when treating the elderly, especially with Duloxetine Lilly 120 mg per day for major depressive disorder or generalised anxiety disorder, for which data are limited (see sections 4.4 and 5.2).
Slovenian: Vendar pa je, kot pri vseh zdravilih, pri zdravljenju starejših potrebna previdnost, posebno z zdravilom Duloksetin Lilly 120 mg na dan za zdravljenje velike depresivne motnje ali generalizirane anksiozne motnje, za kar je na voljo malo podatkov (glejte poglavji 4.4 in 5.2).
English: Duloxetine Lilly should be used in pregnancy only if the potential benefit justifies the potential risk to the foetus.
Slovenian: Zdravilo Duloksetin Lilly naj se v nosečnosti uporablja le, če možna korist upravičuje možno tveganje za plod.
English: Cases of overdoses, alone or in combination with other medicinal products, with duloxetine doses of 5400 mg were reported.
Slovenian: Poročali so o primerih prevelikega odmerjanja duloksetina samega ali v kombinaciji z drugimi zdravili, s 5400 mg odmerki duloksetina.
English: Patients (and caregivers of patients) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.
Slovenian: Bolnike (in njihove skrbnike) je treba opozoriti, da morajo biti pozorni na kakršnokoli klinično poslabšanje, pojav samomorilnega vedenja, misli na samomor in pojav neobičajnih vedenjskih sprememb, ter da se morajo v primeru, da takšni simptomi ne minejo, nemudoma posvetovati z zdravnikom.
English: Also, the long-term safety effects concerning growth, maturation, and cognitive and behavioural development of Duloxetine Lilly in this age group have not yet been demonstrated.
Slovenian: Dolgoročni učinki zdravila Duloksetin Lilly na varnost glede rasti, dozorevanja in kognitivnega ter vedenjskega razvoja v tej starostni skupini tudi še niso bili ugotovljeni.
English: Myoclonus Akathisia7
Slovenian: Mioklonus Akatizija7
English: For depression and diabetic neuropathic pain:
Slovenian: Za depresijo in bolečino diabetične nevropatije:
English: Inducers of CYP1A2: Population pharmacokinetic analyses have shown that smokers have almost 50% lower plasma concentrations of duloxetine compared with non-smokers.
Slovenian: Induktorji CYP1A2: analize populacijske farmakokinetike so pokazale, da imajo kadilci v primerjavi z nekadilci skoraj za 50 % nižje plazemske koncentracije duloksetina.
English: Duloxetine is extensively metabolised and the metabolites are excreted principally in urine.
Slovenian: Duloksetin se obsežno presnavlja, presnovki se izločajo predvsem v urinu.
English: Duloxetine Lilly starts to work in most people with depression or anxiety within two weeks of starting treatment, but it may take 2-4 weeks before you feel better.
Slovenian: Pri večini bolnikov z depresijo ali anksioznostjo začne zdravilo Duloksetin Lilly delovati v dveh tednih po začetku zdravljenja, lahko pa traja 2 do 4 tedne, preden se boste počutili boljše.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred jemanjem tega zdravila pogovorite z njim.
English: Patients with a history of suicide-related events or those exhibiting a significant degree of suicidal thoughts prior to commencement of treatment are known to be at greater risk of suicidal thoughts or suicidal behaviour, and should receive careful monitoring during treatment.
Slovenian: Znano je, da pri bolnikih s samomorom povezanimi dogodki v anamnezi, ali bolnikih, ki kažejo znatno stopnjo samomorilne miselnosti pred uvedbo zdravljenja, obstaja večje tveganje za samomorilne misli ali poskusov samomora in jih je treba med zdravljenjem skrbno spremljati.
English: It weakly inhibits dopamine reuptake with no significant affinity for histaminergic, dopaminergic, cholinergic and adrenergic receptors.
Slovenian: Šibko zavira prevzem dopamina brez pomembne afinitete za histaminergične, dopaminergične, holinergične in adrenergične receptorje.
English: Abrupt discontinuation should be avoided.
Slovenian: Izogibati se moramo nenadni prekinitvi zdravljenja.
English: The safety and efficacy of duloxetine for the treatment of diabetic peripheral neuropathic pain has not been studied.
Slovenian: Varnost in učinkovitost duloksetina za zdravljenje bolečine periferne diabetične nevropatije nista bili dokazani.
English: Stevens-Johnson Syndrome6
Slovenian: StevensJohnsonov sindrom6
English: • night sweats, hives, cold sweats, sensitivity to sunlight, increased tendency to bruise
Slovenian: • nočno potenje, koprivnica, hladen znoj, občutljivost na sončno svetlobo, povečano nagnjenje k modricam
English: These two studies included a 10 week placebo and active (fluoxetine) controlled acute phase followed by six months period of active controlled extension treatment.
Slovenian: Ti dve študiji sta obsegali 10-tedensko akutno fazo s placebom in aktivno kontrolo (fluoksetinom), čemur je sledilo 6mesečno podaljšano obdobje z aktivno kontrolo.
English: If concomitant treatment with duloxetine and other serotonergic agents that may affect the serotonergic and/or dopaminergic neurotransmitter systems is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.
Slovenian: Če je sočasno zdravljenje z duloksetinom in drugimi serotonergičnimi zdravili, ki lahko vplivajo na serotonergične in/ali dopaminergične nevrotransmiterske sisteme klinično upravičeno, je priporočljivo bolnika skrbno nadzirati, še posebej med uvajanjem zdravljenja in pri zviševanju odmerkov.
English: Elimination The elimination half-life of duloxetine ranges from 8 to 17 hours (mean of 12 hours).
Slovenian: Razpolovni čas izločanja duloksetina je od 8 do 17 ur (povprečno 12 ur).
English: For patients who experience a sustained increase in blood pressure while receiving duloxetine either dose reduction or gradual discontinuation should be considered (see section 4.8).
Slovenian: Pri bolnikih, ki so doživeli vztrajno povišanje krvnega tlaka medtem, ko so prejemali duloksetin, je potrebno pretehtati znižanje odmerka ali postopno ukinitev (glejte poglavje 4 8).
English: Oral anticoagulants or antiplatelet agents: Medicines which thin the blood or prevent the blood from clotting.
Slovenian: Peroralni antikoagulanti ali antitrombotiki: zdravila za redčenje krvi ali preprečevanje strjevanja krvi.
English: The safety and efficacy of duloxetine for the treatment of generalised anxiety disorder in paediatric patients aged 7-17 years have not been established.
Slovenian: Varnost in učinkovitost duloksetina za zdravljenje generalizirane anksiozne motnje pri pediatričnih bolnikih, starih od 7 do 17 let, nista bili ugotovljeni.
English: Caution is required in patients at increased risk for hyponatraemia, such as elderly, cirrhotic, or dehydrated patients or patients treated with diuretics.
Slovenian: Previdnost je potrebna pri bolnikih z večjim tveganjem za hiponatriemijo; denimo pri starejših, bolnikih s cirozo, dehidriranih bolnikih ali bolnikih, ki jemljejo diuretike.
English: Use in children and adolescents under 18 years of age Duloxetine Lilly should not be used in the treatment of children and adolescents under the age of 18 years.
Slovenian: Uporaba pri otrocih in mladostnikih, mlajših od 18 let Zdravila Duloksetin Lilly pri zdravljenju otrok in mladostnikov, mlajših od 18 let, ne smemo uporabljati.
English: Each capsule may contain up to 56 mg sucrose.
Slovenian: Ena kapsula lahko vsebuje do 56 mg saharoze.
English: Diabetic Peripheral Neuropathic Pain: As with other medicinal products with similar pharmacological action (antidepressants), isolated cases of suicidal ideation and suicidal behaviours have been reported during duloxetine therapy or early after treatment discontinuation.
Slovenian: Bolečina diabetične periferne nevropatije: kot pri drugih zdravilih s podobnim farmakološkim delovanjem (antidepresivi) so med zdravljenjem z duloksetinom ali kmalu po prenehanju zdravljenja poročali o posameznih primerih samomorilnih idej in samomorilnega vedenja.
English: Female rats receiving duloxetine (45 mg/kg/day) before and during mating and early pregnancy had a decrease in maternal food consumption and body weight, oestrous cycle disruption, decreased live birth indices and progeny survival, and progeny growth retardation at systemic exposure levels estimated to be at the most at maximum clinical exposure (AUC).
Slovenian: Podganje samice, ki so prejemale duloksetin (45 mg/kg/dan) pred in med parjenjem ter zgodnjo brejostjo, so kazale zmanjšano porabo hrane in zmanjšanje telesne mase pri materah, motnje estrus ciklusa, zmanjšano število živorojenih in slabše preživetje potomcev ter zastoj rasti potomcev pri sistemskih izpostavljenostih, ocenjenih kot največ maksimalna klinična izpostavljenost (AUC).
English: If you take Duloxetine Lilly near the end of your pregnancy, your baby might have some symptoms when it is born.
Slovenian: Če zdravilo Duloksetin Lilly jemljete proti koncu nosečnosti, se lahko po rojstvu pri vašem otroku pojavijo nekateri simptomi.
English: Female mice receiving duloxetine for 2 years had an increased incidence of hepatocellular adenomas and carcinomas at the high dose only (144 mg/kg/day), but these were considered to be secondary to hepatic microsomal enzyme induction.
Slovenian: Mišje samice, ki so duloksetin prejemale 2 leti, so imele povišano incidenco hepatocelularnih adenomov in karcinomov samo pri visokem odmerku (144 mg/kg/dan), vendar za te velja, da se pojavijo sekundarno zaradi indukcije jetrnih mikrosomskih encimov.
English: Studies in animals have shown reproductive toxicity at systemic exposure levels (AUC) of duloxetine lower than the maximum clinical exposure (see section 5.3).
Slovenian: Študije na živalih so pokazale reproduktivno toksičnost pri nižjih ravneh sistemske izpostavljenosti (AUC) duloksetinu kot je največja klinična izpostavljenost (glejte poglavje 5.3).
English: The disposition of duloxetine was studied in 6 lactating women who were at least 12-weeks postpartum.
Slovenian: Odlaganje duloksetina so preučevali pri 6 doječih ženskah v obdobju najmanj 12 tednov po porodu.
English: For patients with severe renal impairment, see section 4.3.
Slovenian: Za bolnike s hudo okvarjenim delovanjem ledvic glejte poglavje 4.3.
English: Tachycardia Supra-ventricular arrhythmia, mainly atrial fibrillation
Slovenian: Srčne bolezni palpitacije tahikardija supraventrikularna aritmija, zlasti atrijska fibrilacija
English: Generally these symptoms are mild to moderate, however, in some patients they may be severe in intensity.
Slovenian: Navadno so ti simptomi blagi do zmerni, vendar so pri nekaterih bolnikih lahko tudi zelo intenzivni.
English: To help you remember to take Duloxetine Lilly, you may find it easier to take it at the same times every day.
Slovenian: Morda se boste lažje spomnili vzeti zdravilo Duloksetin Lilly, če ga boste jemali vsak dan ob isti uri.
English: Table 1 gives the adverse reactions observed from spontaneous reporting and in placebo-controlled clinical trials.
Slovenian: Preglednica 1 prikazuje neželene učinke, ki so jih opažali v spontanih poročanjih in v s placebom kontroliranih kliničnih preskušanjih.
English: The plasma concentration of duloxetine displays large inter-individual variability (see section 5.2).
Slovenian: Plazemska koncentracija duloksetina izkazuje veliko različnost med posamezniki (glejte poglavje 5.2).
English: • inflammation of the blood vessels in the skin (cutaneous vasculitis)
Slovenian: • vnetje krvnih žil v koži (kožni vaskulitis)
English: Duloxetine has been associated with an increase in blood pressure and clinically significant hypertension in some patients.
Slovenian: Duloksetin je bil pri nekaterih bolnikih povezan s povišanjem krvnega tlaka in klinično pomembno hipertenzijo.
English: Cases of hypertensive crisis have been reported with duloxetine, especially in patients with pre-existing hypertension.
Slovenian: Pri duloksetinu so poročali o primerih hipertenzivne krize, zlasti pri bolnikih z obstoječo hipertenzijo.
English: Although no studies have investigated the association of PPHN to SNRI treatment, this potential risk cannot be ruled out with duloxetine taking into account the related mechanism of action (inhibition of the re-uptake of serotonin).
Slovenian: Čeprav nobena študija ni preiskovala povezanost med PPHN in SNRI, tveganja ob jemanju duloksetina ni mogoče izključiti, saj je potrebno upoštevati, da gre za podoben način delovanja (zaviranje prevzema serotonina).
English: What you need to know before you take Duloxetine Lilly DO NOT take Duloxetine Lilly if you:
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Duloksetin Lilly NE jemljite zdravila Duloksetin Lilly, če:
English: Pharmacotherapeutic group: psychoanaleptics, antidepressants, other antidepressants.
Slovenian: Farmakoterapevtska skupina: psihoanaleptiki, antidepresivi, drugi antidepresivi.
English: The amount of duloxetine in breast milk is approximately 7 µg/day while on 40 mg twice daily dosing.
Slovenian: Količina duloksetina v materinem mleku je ob odmerku 40 mg dvakrat na dan približno 7 μg/dan.
English: These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer.
Slovenian: Po prvi uvedbi zdravljenja z antidepresivi lahko te misli postanejo še hujše, saj ta zdravila začnejo delovati šele čez nekaj časa, običajno čez dva tedna.
English: Duloxetine Lilly may be taken with or without food.
Slovenian: Zdravilo Duloksetin Lilly lahko vzamete s hrano ali brez nje.
English: Data on the use of Duloxetine Lilly 120 mg in elderly patients with major depressive disorder and generalised anxiety disorder are limited.
Slovenian: Podatkov o uporabi zdravila Duloksetin Lilly 120 mg pri starejših bolnikih z veliko depresivno motnjo in generalizirano anksiozno motnjo je malo.
English: The general toxicity profile of duloxetine in juvenile rats was similar to that in adult rats.
Slovenian: Splošni toksikološki profil duloksetina je bil pri mladih podganah podoben kot pri odraslih podganah.
English: Your doctor may continue to give you Duloxetine Lilly when you are feeling better to prevent your depression or anxiety from returning
Slovenian: Zdravnik vam bo morda še naprej predpisoval zdravilo Duloksetin Lilly, tudi ko se boste že bolje počutili, da bi preprečil ponoven pojav depresije ali anksioznosti.
English: − are taking other medicines containing duloxetine (see ‘Other medicines and Duloxetine Lilly')
Slovenian: - jemljete druga zdravila, ki vsebujejo duloksetin (glejte »Druga zdravila in zdravilo Duloksetin Lilly«)
English: For generalised anxiety disorder:
Slovenian: Za generalizirano anksiozno motnjo:
English: The following are reasons why Duloxetine Lilly may not be suitable for you.
Slovenian: Spodaj so našteti razlogi, zaradi katerih morda zdravilo Duloksetin Lilly za vas ni ustrezna.
English: In general, the adverse reaction profile of duloxetine in children and adolescents was similar to that seen for adults.
Slovenian: V splošnem so bili neželeni učinki duloksetina pri otrocih in mladostnikih podobni tistim pri odraslih.
English: Subsequently, over the four- to six-month extension period, patients on average trended toward recovery to their expected baseline weight percentile based on population data from age- and gender-matched peers.
Slovenian: V štiri- do šestmesečnem podaljšanem obdobju se je pri teh bolnikih telesna masa v povprečju povrnila na pričakovani percentil osnovnega stanja, ki je bil določen na osnovi podatkov vrstnikov enake starosti in spola.
English: However, data on elderly patients exposed to the maximum dose (120 mg per day) are limited and, thus, caution is recommended when using this dose with the elderly population.
Slovenian: Vendar pa so podatki o starejših bolnikih, ki so bili izpostavljeni največjemu odmerku (120 mg na dan), omejeni, zato je ob uporabi tega odmerka pri starejši populaciji priporočljiva previdnost.
English: In the extension phase of these studies, which lasted up to 52 weeks, there was an increase in HbA1c in both the duloxetine and routine care groups, but the mean increase was 0.3% greater in the duloxetinetreated group.
Slovenian: V podaljšani fazi teh študij, ki je trajala do 52 tednov, se je vrednost HbA1c zvišala tako v skupini z duloksetinom kot v skupini bolnikov, ki so prejemali rutinsko oskrbo, vendar je bilo srednje zvišanje v skupini, zdravljeni z duloksetinom, večje za 0,3 %.
English: However, the majority of common adverse reactions were mild to moderate, they usually started early in therapy, and most tended to subside even as therapy was continued.
Slovenian: Vendar pa je bila večina pogostih neželenih učinkov blagih do zmernih, običajno so se pojavili kmalu po uvedbi zdravila, večina jih je izzvenela že med nadaljevanjem zdravljenja.
English: Read the leaflet before use.
Slovenian: Pred uporabo preberite priloženo navodilo.
English: • trouble sleeping, feeling agitated, less sex drive, anxiety, difficulty or failure to experience orgasm, unusual dreams
Slovenian: • težave s spanjem, občutek razdraženosti, manjša želja po spolnosti, nemirnost, težave ali nezmožnost doseči orgazem, nenavadne sanje
English: Lactation did not influence duloxetine pharmacokinetics.
Slovenian: Dojenje ni vplivalo na farmakokinetiko duloksetina.
English: As with other serotonergic medicinal products, discontinuation symptoms may occur in the neonate after maternal duloxetine use near term.
Slovenian: Kot pri drugih serotonergičnih zdravilih se lahko pri novorojenčku pojavijo odtegnitveni simptomi, če mati pred porodom uporablja duloksetin.
English: Two randomized, double-blind, parallel clinical trials were performed in 800 paediatric patients aged 7 to 17 years with major depressive disorder (see section 4.2).
Slovenian: Narejeni sta bili dve randomizirani, dvojno slepi, vzporedni klinični študiji na 800 pediatričnih bolnikih z veliko depresivno motnjo, starih od 7 do 17 let (glejte poglavje 4.2).
English: Your doctor should decide whether you can take Duloxetine Lilly with other medicines.
Slovenian: Zdravnik se mora odločiti, ali lahko jemljete zdravilo Duloksetin Lilly z drugimi zdravili.
English: Limited data suggest that the plasma levels of duloxetine are higher in these patients.
Slovenian: Nezadostni podatki kažejo, da so pri teh bolnikih plazemske koncentracije duloksetina višje.
English: When stopping treatment with Duloxetine Lilly the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions (see sections 4.4 and 4.8).
Slovenian: Ob prenehanju zdravljenja z zdravilom Duloksetin Lilly je treba odmerek zdravila v obdobju najmanj enega do dveh tednov postopoma zmanjševati, da zmanjšamo tveganje za pojav odtegnitvenih reakcij (glejte poglavji 4.4 in 4.8).
English: Duloxetine Lilly may cause a sensation of restlessness or an inability to sit or stand still.
Slovenian: Zdravilo Duloksetin Lilly lahko povzroči občutek nemira ali nezmožnosti sedenja ali stanja pri miru.
English: All patients had previously responded to duloxetine during open-label duloxetine treatment (28 to 34 weeks) at a dose of 60 to 120 mg/day.
Slovenian: Vsi bolniki so se predhodno odzvali na duloksetin med zdravljenjem (28 do 34 tednov) v odprti študiji z duloksetinom v odmerkih od 60 do 120 mg na dan.
English: Withdrawal symptoms when treatment is discontinued are common, particularly if discontinuation is abrupt (see section 4.8).
Slovenian: Ob prekinitvi zdravljenja se lahko pojavijo odtegnitveni simptomi, še zlasti, če je prekinitev nenadna (glejte poglavje 4.8).
English: Duloxetine is extensively metabolised by oxidative enzymes (CYP1A2 and the polymorphic CYP2D6), followed by conjugation.
Slovenian: Duloksetin obsežno presnavljajo oksidativni encimi (CYP1A2 in polimorfni CYP2D6), temu sledi konjugacija.
English: • Duloxetine Lilly may cause effects that you may not be aware of, such as increases in liver enzymes or blood levels of potassium, creatine phosphokinase, sugar, or cholesterol
Slovenian: • zvečanje telesne mase • zdravilo Duloksetin Lilly lahko povzroči tudi neželene učinke, ki se jih morda ne zavedate, kot povišanje jetrnih encimov ali krvnega nivoja kalija, kreatinske fosfokinaze, sladkorja ali holesterola.
English: Lilly Hungária Kft. Tel: + 36 1 328 5100
Slovenian: Magyarország Lilly Hungária Kft. Tel: + 36 1 328 5100
English: No dosage adjustment is recommended for elderly patients solely on the basis of age.
Slovenian: Samo na podlagi starosti pri starejših bolnikih prilagajanje odmerka ni potrebno.
English: The co-administration of duloxetine (40 mg twice daily) increases steady state AUC of tolterodine (2 mg twice daily) by 71 %, but does not affect the pharmacokinetics of its active 5-hydroxyl metabolite and no dosage adjustment is recommended.
Slovenian: Sočasno dajanje duloksetina (40 mg dvakrat na dan) poveča AUC tolterodina (2 mg dvakrat na dan) v stanju dinamičnega ravnovesja za 71 %, ne vpliva pa na farmakokinetiko njegovega aktivnega 5-hidroksi presnovka, zato ne priporočamo prilagajanja odmerjanja.
English: Fluvoxamine (100 mg once daily), a potent inhibitor of CYP1A2, decreased the apparent plasma clearance of duloxetine by about 77% and increased AUCo-t 6-fold.
Slovenian: Fluvoksamin (100 mg enkrat na dan), močan zaviralec CYP1A2, je znižal očitni plazemski očistek duloksetina za približno 77 % in povečal AUC0-t za 6-krat.
English: You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet.
Slovenian: Morda bi bilo koristno, če za težave z depresijo ali anksioznostjo poveste sorodniku ali dobremu prijatelju in ga prosite, da prebere navodilo.
English: Inhibitors of CYP1A2: Because CYP1A2 is involved in duloxetine metabolism, concomitant use of duloxetine with potent inhibitors of CYP1A2 is likely to result in higher concentrations of duloxetine.
Slovenian: Zaviralci CYP1A2: ker je CYP1A2 vpleten v presnovo duloksetina, je verjetno, da bo sočasna uporaba duloksetina z močnimi zaviralci CYP1A2 povzročila višje koncentracije duloksetina.
English: Do not take more than the daily amount of Duloxetine Lilly that has been prescribed for you in one day.
Slovenian: Ne zaužijte več zdravila Duloksetin Lilly v enem dnevu, kot vam je bilo predpisano.
English: Duloxetine Lilly increases the levels of serotonin and noradrenaline in the nervous system.
Slovenian: Zdravilo Duloksetin Lilly zviša nivo serotonina in noradrenalina v živčnem sistemu.
English: Duloxetine is used under different trademarks in several indications (treatment of diabetic neuropathic pain, major depressive disorder, generalised anxiety disorder and stress urinary incontinence).
Slovenian: Duloksetin uporabljamo za več indikacij z različnimi zaščitenimi imeni (zdravljenje bolečine pri diabetični nevropatiji, velike depresivne motnje, generalizirane anksiozne motnje in stresne urinske inkontinence).