FrancophonIA/ELRC3.0 huggingface dataset:
English: Dronedarone could increase plasma concentrations of immunosupressants (tacrolimus, sirolimus, everolimus and cyclosporine).
Croatian: Imunosupresivi Dronedaron bi mogao povećati koncentracije imunosupresiva (takrolimus, sirolimus, everolimus i ciklosporin) u plazmi.
English: If this applies to you (or you are not sure), please talk to your doctor or pharmacist before taking MULTAQ.
Croatian: Ako se ovo odnosi na Vas (ili niste sigurni), razgovarajte s liječnikom ili ljekarnikom prije nego što uzmete MULTAQ.
English: The most common reasons for discontinuation of therapy with dronedarone were gastrointestinal disorders (3.2% of patients versus 1.8% in the placebo group).
Croatian: Najčešći razlog prekida liječenja dronedaronom bili su gastrointestinalni poremećaji (3,2% liječenih bolesnika naspram 1,8% ispitanika u skupini koja je primala placebo).
English: The pharmacological action of dronedarone may induce a moderate QTc Bazett prolongation (about 10 msec), related to prolonged repolarisation.
Croatian: Farmakološko djelovanje dronedarona može izazvati blago produljenje QTc-intervala prema Bazettovoj formuli (otprilike 10 ms) povezano s produljenim vremenom repolarizacije.
English: • some medicines for reducing the cholesterol in your blood (such as simvastatin, lovastatin,
Croatian: • neke lijekove za smanjenje razine kolesterola u krvi (kao što su simvastatin, lovastatin, atorvastatin ili rosuvastatin),
English: • inflammation of blood vessels (vasculitis including leukocytoclastic vasculitis).
Croatian: • upala krvnih žila (vaskulitis uključujući leukocitoklastični vaskulitis)
English: It increases effective refractory periods (ERP) of the atrium, atrio-ventricular node, and ventricular ERP was slightly prolonged with a minimal degree of reverse frequency dependency.
Croatian: Produljuje efektivno refrakterno razdoblje atrija, atrioventrikularnog čvora, a efektivno refrakterno razdoblje ventrikula bilo je blago produljeno uz minimalni stupanj obrnute frekvencijske ovisnosti.
English: Recurrences of AF (including absence of conversion) were more frequent in the dronedarone group, whereas premature study drug discontinuations due to intolerance were more frequent in the amiodarone group.
Croatian: Recidiv FA (uključujući izostanak konverzije) bio je češći u skupini koja je primala dronedaron, dok je prijevremeni prekid primjene ispitivanoga lijeka zbog nepodnošenja bio češći u skupini koja je primala amiodaron.
English: Dronedarone does not affect the pharmacokinetics of clopidogrel and its active metabolite.
Croatian: Dronedaron ne utječe na farmakokinetiku klopidrogela ni njegovog aktivnog metabolita.
English: • some medicines against blood clot formation such as warfarin,
Croatian: • neke lijekove protiv stvaranja krvnih ugrušaka, kao što je varfarin,
English: The safety profile of dronedarone 400 mg twice daily in patients with atrial fibrillation (AF) or atrial flutter (AFL) is based on 5 placebo controlled studies, in which a total of 6,285 patients were randomised (3,282 patients received dronedarone 400 mg twice daily, and 2,875 received placebo).
Croatian: Sigurnosni profil dronedarona u dozi od 400 mg dvaput na dan u bolesnika s fibrilacijom atrija ili undulacijom atrija temelji se na 5 placebom kontroliranih ispitivanja u kojima je randomizirano ukupno 6285 bolesnika (3282 bolesnika primala su dronedaron u dozi od 400 mg dvaput na dan, a 2875 bolesnika primala su placebo).
English: a Determined from Cox regression model b P-value of interaction between baseline characteristics and treatment based on Cox regression model c Calcium antagonists with heart rate lowering effects restricted to diltiazem, verapamil and bepridil
Croatian: a Određeno na temelju Coxova regresijskog modela b P-vrijednost interakcije između početnih obilježja i liječenja na temelju Coxova regresijskog modela c Antagonisti kalcija koji utječu na usporavanje srčanog ritma ograničeni na diltiazem, verapamil i bepridil
English: Dronedarone has no significant potential to inhibit CYP 1A2, CYP 2C9, CYP 2C19, CYP 2C8 and CYP 2B6.
Croatian: Dronedaron nema značajnog potencijala za inhibiciju CYP1A2, CYP2C9, CYP2C19, CYP2C8 ni CYP2B6.
English: There was a weak interaction between dronedarone and statins transported by OATP, such as rosuvastatin (which resulted in a mean 1.4-fold increase in rosuvastatin exposure).
Croatian: Primijećena je slaba interakcija između dronedarona i statina koje transportira OATP, poput rosuvastatina (što je dovelo do srednjeg povećanja izloženosti rosuvastatinu od 1,4 puta).
English: There is limited information on the optimal timing to switch from amiodarone to dronedarone.
Croatian: Podaci o optimalnom vremenu za prelazak s amiodarona na dronedaron su ograničeni.
English: After intravenous administration the plasma clearance of dronedarone ranges from 130 to 150 L/h.
Croatian: Nakon intravenske primjene klirens dronedarona iz plazme kreće se u rasponu od 130 do 150 l/h.
English: As compared to placebo, dronedarone lowered the risk of first AF/AFL recurrence during the 12-month study period by 25% (p = 0.00007).
Croatian: U usporedbi s placebom, dronedaron je tijekom 12-mjesečnog ispitivanja smanjio rizik od prvog recidiva FA/UA za 25% (p = 0,00007).
English: Patients should be advised to consult a physician if they develop or experience signs or symptoms of heart failure, such as weight gain, dependent oedema, or increased dyspnoea.
Croatian: Bolesnike treba uputiti da se obrate liječniku ako razviju ili primijete znakove ili simptome zatajenja srca, poput povećanja tjelesne težine, hipostatskog edema ili pojačane dispneje.
English: After repeated administration of 400 mg twice daily, steady state is reached within 4 to 8 days of treatment and the mean accumulation ratio for dronedarone ranges from 2.6 to 4.5.
Croatian: Nakon ponovljene primjene doze od 400 mg dvaput na dan stanje dinamičke ravnoteže postiže se unutar 4 do 8 dana liječenja, a srednji omjer kumulacije za dronedaron kreće se u rasponu od 2,6 do 4,5.
English: The reduction in cardiovascular hospitalisation or death from any cause was consistent in all subgroups, irrespective of baseline characteristics or medicinal products (ACE inhibitors or AIIRAs; beta-blockers, digitalis, statins, calcium antagonists, diuretics) (see figure 1).
Croatian: Smanjenje incidencije hospitalizacije zbog kardiovaskularnih razloga ili smrti zbog bilo kojeg uzroka bilo je konzistentno u svim podskupinama, neovisno o početnim obilježjima ili lijekovima (ACE inhibitori ili antagonisti receptora angiotenzina II, beta-blokatori, digitalis, statini, antagonisti kalcija, diuretici) (vidjeti sliku 1).
English: In ESC and ACC/AHA/HRS guidelines dronedarone has a class IA recommendation in patients with paroxysmal/persistent AF and coronary artery disease.
Croatian: U ESC i ACC/AHA/HRS smjernicama dronedaron ima preporuku klase IA u bolesnika s paroksizmalnom/perzistentnom fibrilacijom atrija i bolešću koronarnih arterija.
English: Monoamine Oxidases contribute partially to the metabolism of the active metabolite of dronedarone (see section 4.5).
Croatian: Monoaminooksidaze djelomično pridonose metabolizmu aktivnog metabolita dronedarona (vidjeti dio 4.5).
English: This metabolite contributes to the pharmacological activity of dronedarone in humans.
Croatian: Navedeni metabolit pridonosi farmakološkom djelovanju dronedarona u ljudi.
English: Patients should be carefully evaluated for symptoms of Congestive Heart Failure.
Croatian: Bolesnike treba pažljivo pregledati kako bi se ustanovili mogući simptomi kongestivnog zatajenja srca.
English: Take the next dose when you are normally due to take it.
Croatian: Uzmite sljedeću dozu po uobičajenom rasporedu.
English: The ANDROMEDA study was conducted in 627 patients with left ventricular dysfunction, hospitalised with new or worsening heart failure and who had had at least one episode of shortness of breath on minimal exertion or at rest (NYHA class III or IV) or paroxysmal nocturnal dyspnoea within the month before admission.
Croatian: U kliničkom ispitivanju ANDROMEDA sudjelovalo je 627 bolesnika s disfunkcijom lijeve klijetke koji su hospitalizirani zbog novonastalog ili pogoršanja postojećeg zatajenja srca i koji su imali barem jednu epizodu nedostatka zraka kod minimalnog napora ili u mirovanju (NYHA stupanj III ili IV) ili paroksizmalne noćne dispneje unutar mjesec dana prije hospitalizacije.
English: Talk to your doctor or pharmacist before taking MULTAQ if
Croatian: Obratite se svom liječniku ili ljekarniku prije nego što uzmete MULTAQ
English: Their co-administration is contraindicated (see section 4.3).
Croatian: Njihova istodobna primjena je kontraindicirana (vidjeti dio 4.3).
English: Other moderate inhibitors of CYP3A4 are also likely to increase dronedarone exposure.
Croatian: Ostali umjereni inhibitori CYP3A4 također će vjerojatno povećati izloženost dronedaronu.
English: Dronedarone is a multichannel blocker inhibiting the potassium currents (including IK(Ach), IKur, IKr, IKs) and thus prolonging cardiac action potential and refractory periods (Class III).
Croatian: Dronedaron je višekanalni blokator koji inhibira protok kalija (uključujući IK(Ach), IKur, IKr, IKs) te tako produljuje srčani akcijski potencijal i refrakterna razdoblja (skupina III).
English: The pharmacokinetics of dronedarone and its N-debutyl metabolite both deviate moderately from dose proportionality: a 2-fold increase in dose results in an approximate 2.5- to 3.0-fold increase with respect to Cmax and AUC.
Croatian: Farmakokinetika dronedarona i njegova N-debutil metabolita umjereno odstupa od proporcionalnosti dozi: dvostruko veća doza povećava Cmax i AUC približno 2,5 do 3 puta.
English: Dronedarone is contraindicated in patients with severe renal impairment (creatinine clearance (CrCl) <30 ml/min) (see section 4.3).
Croatian: Dronedaron je kontraindiciran u bolesnika s teškim oštećenjem bubrežne funkcije (klirens kreatinina < 30 ml/min) (vidjeti dio 4.3).
English: • Inflammation of the lungs (including scarring and thickening of the lungs).
Croatian: • Upala pluća (uključujući ožiljke i zadebljanja plućnog tkiva).
English: Women of child bearing potential and pregnancy
Croatian: Žene reproduktivne dobi i trudnoća
English: While you are taking MULTAQ, your doctor may perform tests to check your medical condition and how the medicine is working for you.
Croatian: Za vrijeme uzimanja lijeka MULTAQ liječnik može provoditi pretrage kako bi provjerio Vaše zdravstveno stanje i utvrdio kako lijek djeluje na Vas.
English: Pantoprazole (40 mg once daily), a medicinal product which increases gastric pH without any effect on cytochrome P450, did not interact significantly on dronedarone pharmacokinetics.
Croatian: Pantoprazol (40 mg jednom na dan), lijek koji povećava želučani pH, ali pritom ne utječe na enzime citokrom P450, nije značajno djelovao na farmakokinetiku dronedarona.
English: Lower starting dose and maintenance doses of statins should be considered and patients monitored for clinical signs of muscular toxicity.
Croatian: Treba razmotriti nižu početnu dozu i niže doze održavanja statina, a bolesnike treba nadzirati kako bi se uočili mogući klinički znakovi mišićne toksičnosti.
English: Patients who received amiodarone within 4 weeks prior to randomisation were not included.
Croatian: U ispitivanje nisu bili uključeni bolesnici koji su 4 tjedna prije randomizacije primali amiodaron.
English: Clinical, ECG and biological monitoring is recommended, and digoxin dose should be halved.
Croatian: Preporučuje se klinički, EKG i laboratorijski nadzor, a doza digoksina mora se prepoloviti.
English: There are no or limited amount of data from the use of dronedarone in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni dronedarona u trudnica ograničeni.
English: The most frequent adverse reactions observed with dronedarone 400 mg twice daily in the 5 studies were diarrhoea (9%), nausea (5%) and vomiting (2%), fatigue and asthenia (7%).
Croatian: Najčešće nuspojave primijećene kod primjene dronedarona u dozi od 400 mg dvaput na dan u 5 ispitivanja bile su proljev (9%), mučnina (5%) i povraćanje (2%), umor i astenija (7%).
English: Interaction with metformin (OCT1 and OCT2 substrate)
Croatian: Interakcija s metforminom (supstratom OCT1 i OCT2)
English: In clinical studies, 13% of patients received calcium antagonists concomitantly with dronedarone.
Croatian: U kliničkim je ispitivanjima 13% bolesnika uzimalo antagoniste kalcija istodobno s dronedaronom.
English: However due to presystemic first pass metabolism, the absolute bioavailability of dronedarone (given with food) is 15%.
Croatian: Međutim, zbog predsistemskog metabolizma prvog prolaza, ukupna bioraspoloživost dronedarona (primijenjena uz hranu)
English: No interaction was observed between dronedarone and metformin, an OCT1 and OCT2 substrate.
Croatian: Nije opažena interakcija između dronedarona i metformina, supstrata OCT1 i OCT2.
English: Following oral administration in fed condition, dronedarone is well absorbed (at least 70%).
Croatian: Dronedaron se dobro apsorbira nakon peroralne primjene poslije obroka (najmanje 70%).
English: In female patients, dronedarone exposures and its N-debutyl metabolite exposure are on average 1.3- to 1.9-fold higher as compared to male patients.
Croatian: U žena je izloženost dronedaronu i njegovu N-debutil metabolitu u prosjeku 1,3 do 1,9 puta veća nego u muškaraca.
English: No interaction was observed between dronedarone and losartan and an interaction between dronedarone and other AIIRAs is not expected.
Croatian: Nije opažena interakcija između dronedarona i losartana, a ne očekuje se ni interakcija između dronedarona i drugih antagonista receptora angiotenzina II.
English: sanofi-aventis groupe 54, rue La Boétie F-75008 Paris France
Croatian: sanofi-aventis groupe 54, rue La Boétie F-75008 Pariz Francuska
English: In chronic toxicity studies, slight and reversible phospholipidosis (accumulation of foamy macrophages) was observed in mesenteric lymph nodes mainly in the rat.
Croatian: U ispitivanjima kronične toksičnosti primijećena je blaga i reverzibilna fosfolipidoza (akumulacija pjenastih makrofaga) u mezenterijskim limfnim čvorovima, uglavnom u štakora.
English: Swallow the tablet whole with a drink of water during a meal.
Croatian: Uzimanje lijeka Tabletu progutajte cijelu, s vodom tijekom obroka.
English: International Normalised Ratio (INR) should be closely monitored after initiating dronedarone in patients taking vitamin K antagonists as per their label.
Croatian: Mora se pažljivo pratiti međunarodni normalizirani omjer (INR) nakon početka primjene dronedarona u bolesnika koji uzimaju antagoniste vitamina K, kako je to za njih propisano.
English: Larger increases in creatinine after dronedarone initiation have been reported in the post-marketing setting.
Croatian: Znatnija povećanja vrijednosti kreatinina nakon početka liječenja dronedaronom prijavljena su nakon stavljanja lijeka u promet.
English: Signs include swollen feet or legs, trouble breathing when lying down or sleeping, shortness of breath when moving around, or weight increase.
Croatian: Znakovi uključuju oticanje stopala ili nogu, tegobe s disanjem dok ležite ili spavate, nedostatak zraka kad ste u pokretu ili povećanje tjelesne težine.
English: Interaction with P-gp substrates Digoxin
Croatian: Interakcija sa supstratima P-glikoproteina Digoksin
English: Appropriate investigation and close observation of patients should continue until normalisation of ALT.
Croatian: Treba nastaviti provoditi odgovarajuće pretrage i pomno nadzirati bolesnika sve dok se vrijednosti ALT-a ne normaliziraju.
English: Dronedarone caused marked effects on embryo-foetal development at high doses in rats, such as increased post-implantation losses, reduced foetal and placental weights, and external, visceral and skeletal malformations.
Croatian: Visoke doze dronedarona imale su značajne učinke na embriofetalni razvoj u štakora, poput povećanog broja slučajeva gubitka ploda nakon implantacije, smanjenja težine ploda i posteljice te vanjskih malformacija kao i malformacija unutarnjih organa i kostura.
English: There was a weak interaction between dronedarone and atorvastatin (which resulted in a mean 1.7-fold increase in atorvastatin exposure).
Croatian: Opažena je slaba interakcija između dronedarona i atorvastatina (koja je dovela do srednjeg povećanja izloženosti atorvastatinu od 1,7 puta).
English: Anaphylactic reactions including angioedema
Croatian: Poremećaji imunološkog sustava anafilaktičke reakcije, uključujući angioedem
English: Each tablet also contains 41.65 mg of lactose (as monohydrate).
Croatian: Jedna tableta također sadrži 41,65 mg laktoze (u obliku hidrata).
English: If you need to change from amiodarone (another medicine for irregular heart beat) to MULTAQ, your doctor can provide special recommendations, for example pausing amiodarone before switching.
Croatian: Ako morate prijeći s amiodarona (drugog lijeka za nepravilne otkucaje srca) na MULTAQ, liječnik Vam može dati posebne naputke, na primjer prestanak uzimanja amiodarona prije prelaska na dronedaron.
English: However, your ability to drive and use machines may be affected by side effects such as tiredness.
Croatian: Međutim, na Vašu sposobnost upravljanja vozilima i strojevima mogu utjecati nuspojave poput umora.
English: In clinical trials, there was no evidence of safety concerns when dronedarone was co-administered with statins metabolised by CYP 3A4.
Croatian: U kliničkim ispitivanjima nije bilo dokaza koji bi ukazivali na probleme sa sigurnošću primjene kod istodobne primjene dronedarona i statina koji se metaboliziraju pomoću CYP3A4.
English: The incidence of the primary efficacy endpoint defined as first recurrence of AF or premature study drug discontinuation for intolerance or lack of efficacy at 12 months was 75% in the dronedarone group and 59% in the amiodarone group (hazard ratio = 1.59, log-rank p-value <0.0001).
Croatian: Incidencija primarne mjere ishoda definirane kao prvi recidiv FA ili prijevremeni prekid primjene ispitivanog lijeka zbog nepodnošenja ili nedostatka djelotvornosti u 12. je mjesecu iznosila 75% u skupini koja je primala dronedaron i 59% u skupini koja je primala amiodaron (omjer rizika=1,59; log-rang pvrijednost < 0,0001).
English: Dronedarone can increase exposure of statins that are substrates of CYP 3A4 and/or P-gp substrates.
Croatian: Dronedaron može povećati izloženost statinima koji su supstrati CYP3A4 i/ili supstrati P-gp-a.
English: The marketing authorisation holder shall ensure that Health care professionals who intend to prescribe or dispense MULTAQ are provided or have access to the most recent version of SmPC and MULTAQ Prescriber guide.
Croatian: Nositelj odobrenja mora osigurati da svi zdravstveni djelatnici koji namjeravaju propisivati ili izdavati MULTAQ dobiju ili imaju pristup najnovijem Sažetku opisa svojstva lijeka i Vodiču za liječnike propisivače lijeka MULTAQ.
English: MULTAQ is used if you have a problem with your heart rhythm (your heart beats out of time - atrial fibrillation) and spontaneously, or through a treatment called cardioversion has changed your heartbeat back to normal rhythm.
Croatian: MULTAQ se uzima ako imate tegoba s srčanim ritmom (srce Vam kuca nepravilno - fibrilacija atrija) i kada je spontano ili postupkom zvanim kardioverzija ponovno uspostavljen normalan ritam otkucaja srca.
English: • nefazodone (a medicine for depression),
Croatian: • nefazodon (lijek za depresiju),
English: Sotalol must be stopped before starting dronedarone (see sections 4.2 and 4.3).
Croatian: Liječenje sotalolom mora se prekinuti prije početka uzimanja dronedarona (vidjeti dijelove 4.2 i 4.3).
English: It is unknown whether dronedarone and its metabolites are excreted in human milk.
Croatian: Nije poznato izlučuju li se dronedaron i njegovi metaboliti u majčino mlijeko u ljudi.
English: Overall, due to the pharmacokinetic interaction and possible pharmacodynamic interaction, calcium antagonists with depressant effects on sinus and atrio-ventricular node such as verapamil and diltiazem should be used with caution when associated with dronedarone.
Croatian: Općenito, zbog farmakokinetičke interakcije i moguće farmakodinamičke interakcije, antagoniste kalcija koji djeluju depresorski na sinusni i atrioventrikularni čvor, poput verapamila i diltiazema, treba davati uz oprez ako se primjenjuju s dronedaronom.
English: Hepatocellular liver injury, including life-threatening acute liver failure, has been reported in patients treated with dronedarone in the post-marketing setting.
Croatian: Hepatocelularno oštećenje jetre, uključujući po život opasno akutno zatajenje jetre, prijavljeno je u bolesnika liječenih dronedaronom nakon njegova stavljanja u promet.
English: The incidence of the main safety endpoint defined as the occurrence of thyroid, hepatic, pulmonary, neurological, skin, eye or gastrointestinal specific events or premature study drug discontinuation following any adverse event was reduced by 20% in the dronedarone group compared to the amiodarone group (p = 0.129).
Croatian: Incidencija glavne mjere ishoda ispitivanja povezane sa sigurnošću primjene, koja je definirana kao pojava specifičnih događaja na štitnjači, jetri, plućima, živcima, koži, očima ili u probavnom sustavu ili kao prijevremeni prekid primjene ispitivanoga lijeka nakon bilo koje nuspojave, bila je smanjena za 20% u skupini koja je primala dronedaron u usporedbi sa skupinom koja je primala amiodaron (p = 0,129).
English: Sanofi Winthrop Industrie 1 rue de la Vierge, Ambarès & Lagrave, F-33565 Carbon Blanc Cedex - France
Croatian: Sanofi Winthrop Industrie 1 rue de la Vierge, Ambarès & Lagrave, F-33565 Carbon Blanc Cedex - Francuska
English: Patients ranged in age from 20 to 88 years, with the majority being Caucasian (97%), male (69%) patients.
Croatian: Dob bolesnika kretala se u rasponu od 20 do 88 godina, a većina ih je bila bijele rase (97%) i muškog spola (69%).
English: • some medicines for epilepsy called phenobarbital, carbamazepine or phenytoin,
Croatian: • neke lijekove za liječenje epilepsije koji se zovu fenobarbital, karbamazepin ili fenitoin,
English: Of the total number of subjects in clinical studies of dronedarone, 73% were 65 years of age and over and 34% were 75 years of age and over.
Croatian: Od svih ispitanika u kliničkim ispitivanjima dronedarona njih 73% imalo je 65 ili više godina, a njih 34%
English: It also prevents ventricular tachycardia and ventricular fibrillation in several animal models.
Croatian: U nekoliko životinjskih modela također sprječava ventrikularnu tahikardiju i fibrilaciju ventrikula.
English: If pulmonary toxicity is confirmed, treatment should be discontinued.
Croatian: Ako se potvrdi toksično djelovanje na pluća, liječenje se mora prekinuti.
English: No dose adjustment is required in patients with mild or moderate hepatic impairment (see section 5.2).
Croatian: Nije potrebno prilagođavati dozu u bolesnika s blagim ili umjerenim oštećenjem jetrene funkcije (vidjeti dio 5.2).
English: Sanofi Winthrop Industrie 1 rue de la Vierge Ambarès et Lagrave F-33565 Carbon Blanc Cedex France
Croatian: Sanofi Winthrop Industrie 1 rue de la Vierge Ambarès et Lagrave F-33565 Carbon Blanc Cedex Francuska
English: Dronedarone does not affect the pharmacokinetics of omeprazole, a CYP 2C19 substrate.
Croatian: Dronedaron ne utječe na farmakokinetiku omeprazola, supstrata CYP2C19.
English: Treatment with dronedarone can be initiated in an outpatient setting.
Croatian: Liječenje dronedaronom može se započeti u ambulantnim uvjetima.
English: Twenty five percent (25%) had AF at baseline.
Croatian: Dvadeset i pet posto (25%) bolesnika imalo je fibrilaciju atrija na početku ispitivanja.
English: Concomitant intake of food increases dronedarone bioavailability by on average 2- to 4-fold.
Croatian: Istodoban unos hrane povećava bioraspoloživost dronedarona približno 2 do 4 puta.
English: Therefore, inhibitors and inducers of CYP 3A4 have the potential to interact on dronedarone.
Croatian: Stoga inhibitori i induktori CYP3A4 mogu ući u interakciju s dronedaronom.
English: Interaction with theophylline (CYP 1A2 substrate)
Croatian: Interakcija s teofilinom (supstratom CYP1A2)