FrancophonIA/ELRC3.0 huggingface dataset:
English: When normalized for body weight, male and female subjects revealed no major differences in plasma and urinary pharmacokinetic parameters of free and total cobalamins-(III) following the administration of 5 g or 10 g Cyanokit.
Croatian: Kad su normalizirani po tjelesnoj težini, muški i ženski ispitanici nisu pokazali velike razlike u plazmatskim i urinarnim farmakokinetičkim parametrima slobodnih i ukupnih kobalamina-(III) nakon primjene 5 g ili 10 g lijeka Cyanokit.
English: Interference with burn assessment
Croatian: Interferencija s procjenom opeklina
English: Based on in vitro studies and pharmacokinetic data obtained in healthy volunteers the following table describes interference with laboratory tests that may be observed following a 5 g dose of hydroxocobalamin.
Croatian: Na temelju in vitro ispitivanja i farmakokinetičkih podataka dobivenih od zdravih dobrovoljaca sljedeća tablica opisuje interferencije s laboratorijskim testovima koje se mogu primijetiti nakon doze hidroksokobalamina od 5 g.
English: CARDBOARD BOX
Croatian: KARTONSKA KUTIJA
English: The maximum total recommended dose is 10 g for adults, and 140 mg/kg in children up to a maximum of 10 g.
Croatian: Maksimalna ukupna preporučena doza je 10 g za odrasle i 140 mg/kg za djecu sve do najviše 10 g.
English: Therefore, as a precaution, after Cyanokit administration, regular monitoring of renal function (including blood urea nitrogen and serum creatinine) should be performed until 7 days after drug onset.
Croatian: Stoga je, kao mjeru opreza nakon primjene lijeka Cyanokit, potrebno redovito pratiti funkciju bubrega (uključujući ureu u krvi i kreatinin u serumu) do 7 dana od početka primjene lijeka.
English: Among 144 patients not in initial cardiac arrest whose outcomes were known, 118 (82%) survived.
Croatian: Od 144 bolesnika s poznatim ishodom liječenja koji nisu bili u srčanom arestu od samog početka njih 118 (82%) je preživjelo.
English: The pharmacokinetics of total cobalamins-(III) in this population may be affected by the body's cyanide load, since cyanocobalamin was reported to exhibit a 2-3 times lower half-life than total cobalamins-(III) in healthy volunteers.
Croatian: Na farmakokinetiku ukupnog kobalamina-(III) u ovoj populaciji može utjecati opterećenje cijanidom u tijelu, jer je prijavljeno da cijanokobalamin pokazuje 2-3 puta kraći poluvijek od ukupnih kobalamina-(III) kod zdravih dobrovoljaca.
English: The extent and duration of interference in cyanide-poisoned patients may differ according to the severity of intoxication.
Croatian: Stupanj i trajanje interferencije kod bolesnika otrovanih cijanidom može se razlikovati prema težini intoksikacije.
English: Developmental toxicity, including teratogenicity, was observed in rats and rabbits at dose levels of 150 mg/kg and higher administered daily throughout organogenesis.
Croatian: Razvojna toksičnost, uključujući teratogenost zamijećena je kod štakora i kunića pri razinama doze od 150 mg/kg i višim primijenjenim dnevno tijekom organogeneze.
English: Out of the 20 paediatric patients without initial cardiac arrest, 18 (90%) survived, of whom 4 with sequelae.
Croatian: Od 20 pedijatrijskih bolesnika bez početnog srčanog aresta, 18 (90%) je preživjelo, a od kojih 4 s posljedicama.
English: In vitro tests indicate that the extent and duration of the interference is dependant on numerous factors such as the dose of hydroxocobalamin, analyte, analyte concentration, methodology, analyser, concentrations of cobalamins-(III) including cyanocobalamin and partially the time between sampling and measurement.
Croatian: In vitro testovi indiciraju da je stupanj i trajanje interferencije ovisan o brojnim faktorima, kao što je doza hidroksokobalamina, analita, koncentracija analita, metodologija, analizator, koncentracija kobalamina-(III) uključujući cijanokobalamin, a djelomično i vrijeme između uzorkovanja i mjerenja.
English: Cyanocobalamin is a stable, non-toxic compound that is excreted in the urine.
Croatian: Cijanokobalamin je stabilna, netoksična tvar koja se izlučuje u urinu.
English: Administration of hydroxocobalamin was generally associated with a normalisation of blood pressure (systolic blood pressure > 90 mmHg) in 17 of 21 patients (81%) who had low blood pressure (systolic blood pressure > 0 and ≤ 90 mmHg) after exposure to cyanide.
Croatian: Primjena hidroksokobalamina bila je općenito povezana s normalizacijom krvnog tlaka (sistolički krvni tlak > 90 mmHg) kod 17 od 21 bolesnika (81%) koji su imali nizak krvni tlak (sistolički krvni tlak > 0 i ≤ 90 mmHg) nakon izlaganja cijanidu.
English: This should be considered before haemodialysis is initiated in patients treated with hydroxocobalamin.
Croatian: To se mora uzeti u obzir prije početka hemodijalize kod bolesnika liječenih hidroksokobalaminom.
English: Allergic reactions including angioneurotic oedema, skin eruption, urticaria and pruritus.
Croatian: Alergijske reakcije uključujući angioneurotski edem, izbijanje kožnih promjena, urtikariju i pruritus.
English: Known hypersensitivity to hydroxocobalamin or vitamin B12 must be taken into benefit-risk consideration before administration of Cyanokit, since hypersensitive reactions may occur in patients receiving hydroxocobalamin (see section 4.8).
Croatian: Utvrđenu preosjetljivost na hidroksokobalamin ili vitamin B12 treba imati na umu kod razmatranja odnosa koristi i rizika prije primjene lijeka Cyanokit, jer se reakcije preosjetljivosti mogu pojaviti kod bolesnika koji primaju hidroksokobalamin (vidjeti dio 4.8).
English: Observed in vitro interferences of hydroxocobalamin with laboratory tests
Croatian: Primijećene in vitro interferencije hidroksokobalamina s laboratorijskim testovima
English: The safety of administering other cyanide antidotes simultaneously with Cyanokit has not been established (see section 6.2).
Croatian: Sigurnost primjene drugih protuotrova za cijanid istodobno s lijekom Cyanokit nije utvrđena (vidjeti dio 6.2).
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 6 hours at 2°C to 8°C.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja i uvjeti prije primjene odgovornost su korisnika i normalno ne bi trebali biti dulji od 6 sati pri 2 °C do 8 °C.
English: Because the reconstituted solution is a dark red solution, some insoluble particles may not be seen.
Croatian: S obzirom na to da je rekonstituirana otopina tamno crvene boje, neke netopljive čestice možda se neće vidjeti.
English: In particular, liver fibrosis was observed in dogs after administration of hydroxocobalamin for 4 weeks at 300 mg/kg.
Croatian: Posebice je zamijećena fibroza jetre kod pasa nakon primjene hidroksokobalamina tijekom 4 tjedna pri 300 mg/kg.
English: In general, the effectiveness of hydroxocobalamin in paediatric patients was similar to that of adults.
Croatian: Općenito je učinkovitost hidroksokobalamina kod pedijatrijskih bolesnika bila slična onoj kod odraslih.
English: Although the safety and efficacy of hydroxocobalamin have not been studied in renal and hepatic impairments, Cyanokit is administered as emergency therapy in an acute, life-threatening situation only and no dose adjustment is required in these patients.
Croatian: Iako sigurnost i djelotvornost hidroksokobalamina nije ispitivana kod oštećenja bubrega i jetre, Cyanokit se primjenjuje samo kao urgentna terapija u akutnim i po život opasnim situacijama u kojima nije potrebna prilagodba doze kod tih bolesnika.
English: Cyanokit is to be administered together with appropriate decontamination and supportive measures.
Croatian: Cyanokit se primjenjuje zajedno s odgovarajućom dekontaminacijom i potpornim mjerama.
English: Your doctor will recommend you to stop breast-feeding after treatment with Cyanokit.
Croatian: Liječnik će Vam preporučiti prekid dojenja nakon liječenja lijekom Cyanokit.
English: In the setting of multiple casualties such as terrorism or chemical disaster, panic symptoms including tachypnoea and vomiting may mimic early cyanide poisoning signs.
Croatian: U slučajevima višestrukih nesreća poput terorističkih napada ili kemijske katastrofe, panični simptomi uključujući tahipneju i povraćanje mogu oponašati rane znakove trovanja cijanidom.
English: The mean total amount of cobalamins-(III) excreted in urine during the collection period of 72 hours was approximately 60% of a 5 g dose and approximately 50% of a 10 g dose of Cyanokit.
Croatian: Srednja vrijednost ukupne količine kobalamina-(III) izlučenog u urinu tijekom razdoblja prikupljanja od 72 sata iznosila je približno 60% doze od 5 g i približno 50% doze od 10 g Cyanokita.
English: For storage conditions of the reconstituted medicine, see 'Handling instructions' at the end of this package leaflet.
Croatian: Za uvjete čuvanja pripremljenog lijeka pogledajte „Upute za rukovanje“ na kraju ove Upute o lijeku.
English: The 75 mg/kg and 150 mg/kg doses are approximately equivalent to 5 g and 10 g of hydroxocobalamin, respectively, in humans, not only on a body weight basis but also on Cmax basis of hydroxocobalamin [total cobalamins-(III), see section 5.2].
Croatian: Doze od 75 mg/kg i 150 mg/kg približno su jednake dozama od 5 i 10 g hidroksokobalamina kod ljudi i to ne samo na temelju tjelesne težine već i na temelju Cmax hidroksokobalamina [ukupni kobalamini-(III), vidjeti dio 5.2].
English: • discomfort in your stomach
Croatian: • nelagoda u trbuhu
English: Heart and blood pressure problems
Croatian: Tegobe sa srcem i krvnim tlakom
English: Because hydroxocobalamin will be administered in potentially life-threatening situations, breastfeeding is not a contraindication to its use.
Croatian: S obzirom na to da se hidroksokobalamin primjenjuje u potencijalno po život opasnim situacijama, dojenje nije kontraindikacija njegovoj primjeni.
English: Pharmacotherapeutic group: Antidotes, ATC code: V03AB33
Croatian: FARMAKOLOŠKA SVOJSTVA 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: protuotrovi, ATK oznaka: V03AB33
English: / SEMOY 2, rue du Pressoir Vert 45400 Semoy
Croatian: Merck Santé s.a.s. / SEMOY 2, rue du Pressoir Vert 45400 Semoy
English: Other medicines and Cyanokit
Croatian: Drugi lijekovi i Cyanokit
English: In order to reflect the exposure to the sum of all derivatives, pharmacokinetics of cobalamins-(III) were investigated instead of hydroxocobalamin, requiring the concentration unit µg eq/mL (i.e. cobalamin-(III) entity without specific ligand).
Croatian: Kako bi se prikazala izloženost zbroja svih derivata, umjesto farmakokinetike hidroksokobalamina ispitivana je farmakokinetika kobalamina-(III), za što je bila potrebna jedinica koncentracije µg eq/mL (tj. kobalamin-(III) bez specifičnog liganda).
English: The effectiveness of hydroxocobalamin was examined in a controlled study in cyanide-poisoned adult dogs.
Croatian: Učinkovitost hidroksokobalamina ispitana je u kontroliranom ispitivanju na odraslim psima otrovanima cijanidom.
English: Because of its deep red colour, hydroxocobalamin has the potential to interfere with determination of laboratory parameters (e.g. clinical chemistry, haematology, coagulation, and urine parameters).
Croatian: Zbog svoje intenzivne tamnocrvene boje, hidroksokobalamin može interferirati s određivanjem laboratorijskih parametara (primjerice, kliničke biokemije, hematologije, koagulacije i parametara urina).
English: Signs and symptoms of cyanide poisoning
Croatian: Znakovi i simptomi trovanja cijanidom
English: Hydroxocobalamin 75 mg/kg (N=19)
Croatian: Hidroksokobalamin 75 mg/kg (N=19)
English: Combination with another cyanide antidote: Chemical incompatibility was observed with sodium thiosulfate and sodium nitrite.
Croatian: Kombinacija s drugim protuotrovom za cijanid: Kemijska inkompatibilnost primijećena je s natrijevim tiosulfatom i natrijevim nitritom.
English: The following information is intended for medical or healthcare professionals only:
Croatian: Sljedeće informacije namijenjene su samo liječnicima i zdravstvenim djelatnicima: Upute za rukovanje
English: The rapid and complete recovery of haemodynamics and subsequently of blood gases, pH, and lactate after cyanide poisoning likely contributed to the better outcome of the hydroxocobalamin-treated animals.
Croatian: Brzi i potpuni oporavak hemodinamike te naknadno plinova u krvi, pH i laktata nakon trovanja cijanidom, vjerojatno je povezan s boljim ishodom kod životinja liječenih hidroksokobalaminom.
English: A total of 347 subjects were exposed to hydroxocobalamin in clinical studies.
Croatian: Ukupno 347 ispitanika bilo je izloženo hidroksokobalaminu u kliničkim ispitivanjima.
English: The following side effects may be expected (frequency cannot be estimated from the available data):
Croatian: Mogu se očekivati sljedeće nuspojave (učestalost se ne može procijeniti iz dostupnih podataka): Alergija (preosjetljivost)
English: Each pack contains two vials (each vial packed in one cardboard box), two sterile transfer devices, one sterile intravenous infusion set and one sterile short catheter for administration to children.
Croatian: Jedno pakiranje sadrži dvije bočice (svaka bočica pakirana zasebno u kartonskoj kutiji), dva uređaja za sterilni prijenos, jedan sterilni set za intravensku infuziju i jedan sterilni kratki kateter za primjenu kod djece.
English: Histopathology revealed brain lesions that were consistent with cyanide-induced hypoxia.
Croatian: Histopatološke analize pokazale su lezije mozga koje su bile sukladne s hipoksijom induciranom cijanidom.
English: The intravenous infusion set provided in the kit must then be used as it includes an appropriate filter and is to be primed with the reconstituted solution.
Croatian: Iz tog razloga mora se koristiti set za intravensku infuziju koji se nalazi u priboru, jer uključuje odgovarajući filtar te ga treba pripremiti rekonstituiranom otopinom.
English: Dark red crystalline powder.
Croatian: Tamnocrveni kristalinični prašak.
English: Transient increase in blood pressure, usually resolving within several hours; hot flush.
Croatian: Prolazni porast krvnog tlaka koji se obično povlači unutar nekoliko sati, navala vrućine.
English: The low molecular weight cobalamins-(III) formed including hydroxocobalamin are termed free cobalamins-(III); the sum of free and protein-bound cobalamins is termed total cobalamins-(III).
Croatian: Kompleksi kobalamina-(III) niske molekularne težine uključujući hidroksokobalamin nazivaju se slobodni kobalamini-(III); zbroj slobodnih i za proteine vezanih kobalamina nazivaju se ukupni kobalamini-(III).
English: Pleural effusion, dyspnoea, throat tightness, dry throat, chest discomfort.
Croatian: Pleuralni izljev, dispneja, stezanje u grlu, suho grlo, nelagoda u prsima.
English: This kit does not contain diluent.
Croatian: Ovaj komplet ne sadrži otapalo.
English: Treatment decisions must be made on the basis of clinical history and/or signs and symptoms of cyanide intoxication.
Croatian: Odluku o liječenju treba donijeti na temelju kliničke anamneze i/ili znakova i simptoma intoksikacije cijanidom.
English: The predominant mean half-life of free and total cobalamins-(III) was approximately 26 to 31 hours at the 5 and 10 g dose level.
Croatian: Prevladavajuća srednja vrijednost poluvijeka slobodnih i ukupnih kobalamina-(III) iznosila je približno od 26 do 31 sat pri dozama od 5 i 10 g.
English: The action of hydroxocobalamin in the treatment of cyanide poisoning is based on its ability to tightly bind cyanide ions.
Croatian: Djelovanje hidroksokobalamina u liječenju trovanja cijanidom temelji se na njegovoj sposobnosti čvrstog vezanja iona cijanida.
English: Cyanokit may cause red discolouration of the plasma, which may cause artificial elevation or reduction in the levels of certain laboratory parameters (see section 4.4).
Croatian: Cyanokit može uzrokovati promjenu boje plazme, koja može uzrokovati umjetno povišenje ili smanjenje razina određenih laboratorijskih parametara (vidjeti dio 4.4).
English: The mean age of the paediatric patients was about six years and the mean dose of hydroxocobalamin was about 120 mg/kg body weight.
Croatian: Prosječna dob pedijatrijskih bolesnika iznosila je oko šest godina, a prosječna doza hidroksokobalamina oko 120 mg/kg tjelesne težine.
English: Sources of cyanide poisoning include hydrogen cyanide and its salts, cyanogens, including cyanogenic plants, aliphatic nitriles, or prolonged exposure to sodium nitroprusside.
Croatian: Izvori trovanja cijanidom uključuju cijanovodik i njegove soli, cijanogene, uključujući cijanogene biljke, alifatske nitrile ili produljeno izlaganje natrijevom nitroprusidu.
English: • transport in the desert (4 days submitted to temperatures ranging from 5 to 60°C) and
Croatian: • transportu u pustinji (4 dana izložen temperaturama u rasponu od 5 °C do 60 °C) i
English: In the absence of data in breast-fed infants, breast-feeding discontinuation is recommended after receiving Cyanokit.
Croatian: U odsutnosti podataka kod dojene djece, preporučuje se prekid dojenja nakon primanja lijeka Cyanokit.
English: Preparation of Cyanokit
Croatian: Priprema Cyanokita
English: Sodium chloride 9 mg/mL (N=17)
Croatian: Natrijev klorid 9 mg/mL (N=17)
English: Initial dose of Cyanokit is administered as an intravenous infusion over 15 minutes.
Croatian: Početna doza Cyanokita primjenjuje se kao intravenska infuzija tijekom 15 minuta.
English: Detailed information for your doctor or other health care professional regarding simultaneous administration of Cyanokit with other medicines can be found at the end of this package leaflet (see 'Handling instructions').
Croatian: Detaljne upute za Vašeg liječnika ili drugog zdravstvenog djelatnika u vezi istodobne primjene Cyanokita s drugim lijekovima mogu se naći na kraju ove Upute o lijeku (vidjeti „Upute za rukovanje“).
English: A total of 245 patients with suspected or known cyanide-poisoning were included in the clinical studies of the efficacy of hydroxocobalamin as an antidote.
Croatian: Ukupno 245 bolesnika sa suspektnim ili utvrđenim trovanjem cijanidom bili su uključeni u klinička ispitivanja djelotvornosti hidroksokobalamina kao protuotrova.
English: They will have to take it into account before treating you with Cyanokit.
Croatian: To se mora uzeti u obzir prije liječenja Cyanokitom.
English: In the presence of the above signs, treatment with Cyanokit must not be delayed to obtain a plasma lactate concentration.
Croatian: U prisutnosti prethodno navedenih znakova liječenje lijekom Cyanokit ne smije se odgoditi da se održi odgovarajuća koncentracija laktata u plazmi.
English: • The other ingredient is hydrochloric acid (for pH adjustment).
Croatian: • Drugi sastojak je kloridna kiselina (za podešavanje pH).
English: • Acute renal failure with acute tubular necrosis, renal impairment, urine calcium oxalate crystals present (see section 4.4).
Croatian: • Akutno zatajenje bubrega s akutnom tubularnom nekrozom, oštećenje funkcije bubrega, kristali kalcijevog oksalata u mokraći (vidjeti dio 4.4).
English: Detailed instructions for your doctor or other health care professional on how to prepare the Cyanokit infusion and how to determine the dose can be found at the end of this package leaflet (see 'Handling instructions').
Croatian: Detaljne upute za Vašeg liječnika ili drugog zdravstvenog djelatnika o načinu pripreme infuzije Cyanokita te određivanju doze mogu se naći na kraju ove Upute o lijeku (vidjeti „Upute za rukovanje“).
English: You will have the first infusion of Cyanokit over 15 minutes.
Croatian: Prvu infuziju lijeka Cyanokit primat ćete u trajanju od 15 minuta.
English: Hydroxocobalamin will lower blood cyanide concentrations.
Croatian: Hidroksobalamin će sniziti koncentracije cijanida u krvi.
English: Interference with haemodialysis
Croatian: Interferencija s hemodijalizom
English: Dogs were poisoned by intravenous administration of a lethal dose of potassium cyanide.
Croatian: Psi su otrovani intravenskom primjenom smrtonosne doze kalijeva cijanida.
English: Analysers used: ACL Futura (Instrumentation Laboratory), Axsym/Architect (Abbott), BM Coasys (Boehringer Mannheim), CellDyn 3700 (Abbott), Clinitek 500 (Bayer), Cobas Integra 700, 400 (Roche), Gen-S Coultronics, Hitachi 917, STA
Croatian: (Boehringer Mannheim), CellDyn 3700 (Abbott), Clinitek 500 (Bayer), Cobas Integra 700, 400 (Roche), Gen-S Coultronics, Hitachi 917, STA
English: Following intravenous administration of Cyanokit, significant binding to plasma proteins and low molecular weight physiological compounds occurs, to form various cobalamin-(III) complexes by replacing the hydroxo ligand.
Croatian: Nakon intravenske primjene Cyanokita, događa se značajno vezivanje na proteine plazme i fiziološke tvari niske molekularne težine, kako bi nastali različiti kompleksi kobalamina-(III) zamjenom hidrokso liganda.
English: Cyanokit may interfere with burn assessment (red coloration of the skin) and laboratory tests and may lead to shut down of haemodialysis machines (see SmPC).”
Croatian: Cyanokit može interferirati s procjenom opeklina (crveno obojenje kože) i laboratorijskim testovima te može uzrokovati prestanak rada uređaja za hemodijalizu (vidjeti Sažetak opisa svojstava lijeka).“
English: Each pack contains one vial packed in one cardboard box, one sterile transfer device, one sterile intravenous infusion set and one sterile short catheter for administration to children.
Croatian: Jedno pakiranje sadrži jednu bočicu u kartonskoj kutiji, jedan uređaj za sterilni prijenos, jedan sterilni set za intravensku infuziju i jedan sterilni kratki kateter za primjenu kod djece.
English: • most patients will experience a reversible red colouration of the skin and membranes lining body cavities (mucous membranes) that may last up to 15 days after administration of Cyanokit.
Croatian: • većina bolesnika iskusit će prolazno obojenje kože u crveno kao i membrana koje oblažu šupljine tijela (sluznice) koje može trajati do 15 dana nakon primjene lijeka Cyanokit.
English: In anaesthetised rabbits, hydroxocobalamin exerted haemodynamic effects (increased mean arterial blood pressure and total peripheral resistance, decreased cardiac output) related to its nitric oxidescavenging property.
Croatian: Kod anesteziranih zečeva hidroksokobalamin je pokazao hemodinamičke učinke (povećana srednja vrijednost arterijskog tlaka i ukupna periferna rezistencija te smanjen minutni volumen srca) što se povezuje s njegovim svojstvima uklanjanja dušikova oksida.
English: Cyanokit is to be administered together with appropriate decontamination and supportive measures (see section 4.4).
Croatian: Cyanokit treba primjenjivati s odgovarajućim suportivnim mjerama i mjerama dekontaminacije (vidjeti dio 4.4).
English: In-use stability of the reconstituted solution
Croatian: Stabilnost rekonstituirane otopine u primjeni
English: Common signs and symptoms of cyanide poisoning include: nausea, vomiting, headache, altered mental status (e.g. confusion, disorientation), chest tightness, dyspnoea, tachypnoea or hyperpnoea (early), bradypnoea or apnoea (late), hypertension (early) or hypotension (late), cardiovascular collapse, seizures or coma, mydriasis, and plasma lactate concentration > 8 mmol/L.
Croatian: Česti znaci i simptomi trovanja cijanidom uključuju: mučninu, povraćanje, glavobolju, izmijenjeni mentalni status (npr. konfuzija, gubitak orijentacije), stezanje u prsima, dispneju, tahipneju ili hiperpneju (ranu), bradipneju ili apneju (kasnu), hipertenziju (ranu) ili hipotenziju (kasnu), kardiovaskularni kolaps, napadaje ili komu, midrijazu i plazmatske razine laktata > 8 mmol/l.
English: Survival of cyanide-poisoned dogs
Croatian: Preživljavanja pasa otrovanih cijanidom
English: Cyanokit is an antidote for the treatment of known or suspected cyanide poisoning in all age ranges.
Croatian: Cyanokit je protuotrov za liječenje dokazanog ili sumnjivog trovanja cijanidom za sve dobne skupine.
English: Because of its deep red colour, hydroxocobalamin has the potential to induce a red colouration of the skin and therefore may interfere with burn assessment.
Croatian: Zbog svoje intenzivne tamnocrvene boje, hidroksokobalamin može inducirati crveno obojenje kože i stoga može interferirati s procjenom opeklina.