FrancophonIA/ELRC3.0 huggingface dataset:
English: Desloratadine should be administered with caution in patients with medical or familial history of seizures, and mainly young children, being more susceptible to develop new seizures under desloratadine treatment.
Slovenian: Desloratadin je treba uporabljati previdno pri bolnikih z zdravstveno ali družinsko anamnezo epileptičnih napadov, zlasti pri mlajših otrocih, ki so med zdravljenjem z desloratadinom bolj dovzetni za razvoj novih epileptičnih napadov.
English: Treatment of the pseudoephedrine sulphate overdose is symptomatic and supportive.
Slovenian: Zdravljenje prevelikega odmerjanja psevdoefedrinijevega sulfata naj bo simptomatično in podporno.
English: Nevertheless, as there is individual variation in response to all medicinal products, it is recommended that patients are advised not to engage in activities requiring mental alertness, such as driving a car or using machines, until they have established their own response to the medicinal product.
Slovenian: Ker obstajajo individualne razlike v odzivu na vsa zdravila, priporočamo, da se bolnikom odsvetujejo dejavnosti, ki zahtevajo zbranost, kot sta vožnja avtomobila ali upravljanje s stroji, dokler ne vedo, kako se odzivajo na zdravilo.
English: In a multiple-dose pharmacokinetic study conducted with the tablet formulation in healthy adult subjects, four subjects were found to be poor metabolisers of desloratadine.
Slovenian: V farmakokinetični študiji z uporabo večkratnih odmerkov tablet tega zdravila, ki je bila opravljena pri zdravih odraslih preiskovancih, so ugotovili štiri osebe, ki so bile slabi metabolizatorji desloratadina.
English: • severe allergic reactions (difficulty in breathing, wheezing, itching, hives and swelling)
Slovenian: • hude alergijske reakcije (težave z dihanjem, sopihanje, srbenje, koprivnica in otekanje)
English: Following oral administration of Aerinaze for 14 days in normal healthy volunteers, steady-state conditions were reached on day 10 for desloratadine, 3-hydroxydesloratadine and pseudoephedrine sulphate.
Slovenian: Po peroralni uporabi zdravila Aerinaze pri normalnih zdravih prostovoljcih skozi obdobje 14 dni je bilo stanje dinamičnega ravnovesja za desloratadin, 3-hidroksidesloratadin in psevdoefedrin doseženo na 10. dan.
English: Alcohol use should be avoided during Aerinaze treatment.
Slovenian: Med zdravljenjem z zdravilom Aerinaze se je treba izogibati uporabi alkohola.
English: Swallow the tablet whole; do not crush, break or chew the tablet before swallowing.
Slovenian: Tableto pogoltnite celo; preden jo pogoltnete, je ne smete zdrobiti, zlomiti ali žvečiti.
English: As Aerinaze contains pseudoephedrine sulphate, it is also contraindicated in patients who are receiving monoamine oxidase (MAO) inhibitor therapy or during the 2 weeks following the stopping of such treatment.
Slovenian: Ker zdravilo Aerinaze vsebuje psevdoefedrinijev sulfat, je njegova uporaba kontraindicirana tudi pri bolnikih, ki se zdravijo z zaviralci monoaminooksidaze (MAO) oziroma v času 2 tednov po prenehanju zdravljenja z njimi.
English: Antihistamines help to reduce allergic symptoms by preventing the effects of a substance called histamine, which is produced by the body.
Slovenian: Antihistaminiki lajšajo simptome alergije, ker preprečujejo delovanje histamina, snovi, ki nastaja v telesu.
English: The safety and efficacy of Aerinaze have not been established in patients with impaired renal or hepatic function, and there are insufficient data to give adequate dose recommendations.
Slovenian: Varnost in učinkovitost zdravila Aerinaze nista bili dokazani pri bolnikih z okvarjenim delovanjem ledvic ali jeter in ni zadostnih podatkov, da bi podali ustrezna priporočila o odmerjanju.
English: • dry eye
Slovenian: • suho oko
English: Pharmacotherapeutic group: Nasal preparations, nasal decongestants for systemic use, ATC code: R01BA52.
Slovenian: Farmakoterapevtska skupina: Zdravila za bolezni nosne sluznice, nazalni dekongestivi za sistemsko zdravljenje, oznaka ATC: R01BA52.
English: In controlled clinical trials, at the recommended dose of 5 mg daily, there was no excess incidence of somnolence as compared to placebo.
Slovenian: V nadzorovanih kliničnih preskušanjih s priporočenim 5 mg dnevnim odmerkom niso opazili prekomerne incidence zaspanosti v primerjavi s placebom.
English: After improvement of the congestive condition of the mucosae of the upper airway, treatment may be maintained with desloratadine alone, if necessary.
Slovenian: Po zmanjšanju kongestije sluznice zgornjih dihal lahko zdravljenje nadaljujete z desloratadinom samim, če je potrebno.
English: Patients of 60 years or older are more likely to experience adverse reactions to sympathomimetic medicinal products, such as pseudoephedrine sulphate.
Slovenian: Bolniki, stari 60 let ali več, imajo večjo verjetnost za pojav neželenih učinkov pri jemanju simpatikomimetičnih zdravil, kot je psevdoefedrinijev sulfat.
English: Caution should also be exercised in patients being treated with other sympathomimetics (see section 4.5).
Slovenian: Previdnost je potrebna še pri bolnikih, ki se zdravijo z drugimi simpatikomimetiki (glejte poglavje 4.5), vključno z:
English: Oral administration of pseudoephedrine sulphate at the recommended dose can cause other sympathomimetic effects, such as increased blood pressure, tachycardia or manifestations of central nervous system excitation.
Slovenian: Peroralna uporaba psevdoefedrinijevega sulfata v priporočenem odmerku lahko povzroči tudi druge simpatikomimetične učinke, na primer zvišan krvni tlak, tahikardijo ali znake ekscitacije osrednjega živčevja.
English: Other adverse reactions reported for desloratadine during the post-marketing period are listed hereunder.
Slovenian: Drugi neželeni učinki desloratadina, o katerih so poročali v času po prihodu zdravila na trg, so navedeni v nadaljevanju.
English: In a single dose study performed in adults, desloratadine 5 mg did not affect standard measures of flight performance including exacerbation of subjective sleepiness or tasks related to flying.
Slovenian: V študiji z uporabo enkratnih odmerkov, ki so jo opravili pri odraslih preiskovancih, uživanje 5 mg odmerka desloratadina tako ni vplivalo na običajna merila sposobnosti za letenje, na primer na okrepitev subjektivne zaspanosti ali slabšo izvedbo nalog v zvezi z letenjem.
English: Common: the following may affect up to 1 in 10 people
Slovenian: Pogosti: naslednji se lahko pojavijo pri največ 1 od 10 bolnikov
English: Pseudoephedrine sulphate Antacids increase the rate of pseudoephedrine sulphate absorption, kaolin decreases it.
Slovenian: Psevdoefedrinijev sulfat Antacidi povečajo hitrost absorpcije psevdoefedrinijevega sulfata, kaolin pa jo zmanjša.
English: What Aerinaze looks like and contents of the pack
Slovenian: Izgled zdravila Aerinaze in vsebina pakiranja
English: Pack sizes of 2, 4, 7, 10, 14 and 20 tablets.
Slovenian: Velikosti pakiranj: 2, 4, 7, 10, 14 in 20 tablet.
English: As much as possible of the amount administered should be removed before the next instillation.
Slovenian: Pred naslednjim izpiranjem je treba odstraniti čimveč zaužite količine zdravila.
English: As a precautionary measure, it is preferable to avoid the use of Aerinaze during pregnancy.
Slovenian: Iz previdnostnih razlogov se je med nosečnostjo uporabi zdravila Aerinaze bolje izogibati.
English: Short acting barbiturates, diazepam or paraldehyde may be administered to control seizures.
Slovenian: Za nadzor morebitnih epileptičnih napadov lahko uporabite kratkotrajno delujoče barbiturate, diazepam ali paraldehid.
English: Fertility There are no data available on male and female fertility.
Slovenian: Plodnost Podatkov za plodnost pri moških in ženskah ni na voljo.
English: Aerinaze is indicated in adults and adolescents 12 years and older for the symptomatic treatment of seasonal allergic rhinitis when accompanied by nasal congestion.
Slovenian: Zdravilo Aerinaze je indicirano pri odraslih in mladostnikih, starih 12 let in več, za simptomatsko zdravljenje sezonskega alergijskega rinitisa, ki ga spremlja kongestija nosne sluznice.
English: If you take more Aerinaze than you should If you take more Aerinaze than you were told to, tell your doctor, pharmacist or nurse immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Aerinaze, kot bi smeli Če ste vzeli več zdravila Aerinaze, kot vam je bilo predpisano, o tem nemudoma obvestite zdravnika, farmacevta ali medicinsko sestro.
English: • abnormal liver function tests
Slovenian: • nenormalni izvidi preiskav delovanja jeter
English: Food had no effect on the bioavailability (Cmax and AUC) of desloratadine or pseudoephedrine sulphate.
Slovenian: Hrana ni vplivala na biološko uporabnost (Cmax in AUC) desloratadina ali psevdoefedrinijevega sulfata.
English: • a history of haemorrhagic stroke or with risk factors which could increase the risk of haemorrhagic stroke.
Slovenian: • hemoragično možgansko kapjo v pretekli anamnezi ali dejavniki, ki bi lahko povečali tveganje za hemoragično možgansko kap.
English: Adsorption of active substance remaining in the stomach may be attempted by administration of active charcoal suspended in water.
Slovenian: Preostalo učinkovino v želodcu skušajte adsorbirati z dajanjem aktivnega oglja, suspendiranega v vodi.
English: Hyperpyrexia, especially in children, may require treatment with tepid water sponge baths or hypothermia blanket.
Slovenian: V primeru hiperpireksije, še posebej pri otrocih, pa je lahko potrebno zdravljenje z mlačnimi kopelmi s pomočjo spužve ali celo uporaba odeje protie hipotermiji.
English: • anorexogenics or amphetamine-type psychostimulants
Slovenian: • zdravili za zmanjšanje teka ali psihostimulansi amfetaminskega tipa,
English: Concurrent administration with other sympathomimetics (decongestants, anorexogenics or amphetamine-type psychostimulants, antihypertensive medicinal products, tricyclic antidepressants and other antihistamines) may result in critical hypertension reactions (see section 4.4).
Slovenian: Sočasno jemanje z drugimi simpatikomimetiki (dekongestivi, zdravili za zmanjšanje teka ali psihostimulansi amfetaminskega tipa, antihipertenzivi, tricikličnimi antidepresivi in drugimi antihistaminiki) lahko povzroči zelo nevarne hipertenzivne reakcije (glejte poglavje 4.4).
English: Sympathomimetic medicines reduce the antihypertensive effect of α-methyldopa, mecamylamine, reserpine, veratrum alkaloids, and guanethidine.
Slovenian: Simpatikomimetična zdravila zmanjšajo antihipertenzivno delovanje α-metildope, mekamilamina, rezerpina, alkaloidov čmerike (Veratrum) in gvanetidina.
English: The combination of loratadine/pseudoephedrine sulphate used in acute and multiple-dose studies, exhibited a low order of toxicity.
Slovenian: Pri uporabi kombinacije loratadina in psevdoefedrinijevega sulfata v študijah akutnega in večkratnega odmerjanja zdravila je bila toksičnost majhna.
English: Uncommon: the following may affect up to 1 in 100 people
Slovenian: Občasni: naslednji se lahko pojavijo pri največ 1 od 100 bolnikov
English: These subjects had a Cmax concentration about 3-fold higher at approximately 7 hours with a terminal phase half-life of approximately 89 hours.
Slovenian: Pri teh preiskovancih je bila čez približno 7 ur največja koncentracija zdravila Cmax že za približno 3-krat večja, njegova končna razpolovna doba izločanja pa je znašala približno 89 ur.
English: • lisuride, pergolide: risk of vasoconstriction and increase in blood pressure.
Slovenian: • z lisuridom, pergolidom: tveganje za vazokonstrikcijo in povišan krvni tlak.
English: Pseudoephedrine sulphate (d-isoephedrine sulphate) is a sympathomimetic agent with mostly mimetic activity in comparison with the -activity.
Slovenian: Psevdoefedrinijev sulfat (d-izoefedrinijev sulfat) je simpatikomimetično zdravilo, ki ima predvsem mimetično delovanje v nasprotju z  mimetičnim delovanjem.
English: Aerinaze should not be used during breast-feeding.
Slovenian: Zdravilo Aerinaze se med dojenjem ne sme uporabljati.
English: Aerinaze tablets contain a combination of two active ingredients, desloratadine which is an antihistamine and pseudoephedrine sulphate which is a decongestant.
Slovenian: Zdravilo Aerinaze vsebuje kombinacijo dveh učinkovin, desloratadin, ki je antihistaminik, in psevdoefedrinijev sulfat, ki je dekongestiv.
English: • decreased sense of smell
Slovenian: • oslabljen čut za voh
English: Aerinaze is not recommended for use in children below the age of 12 years.
Slovenian: Uporaba zdravila Aerinaze ni priporočljiva pri otrocih, mlajših od 12 let.
English: Desloratadine and pseudoephedrine sulphate have been identified in breastfed newborns/infants of treated women.
Slovenian: Desloratadin in psevdoefedrinijev sulfat so ugotovili pri dojenih novorojencih/otrocih zdravljenih žensk.
English: A component interaction study demonstrated that the exposure (Cmax and AUC) of pseudoephedrine sulphate following administration of pseudoephedrine sulphate alone was bioequivalent to pseudoephedrine sulphate exposure following administration of the Aerinaze tablet.
Slovenian: Študija interakcij med sestavinami zdravila je pokazala, da je izpostavljenost psevdoefedrinijevemu sulfatu (Cmax in AUC) po zaužitju samega psevdoefedrinijevega sulfata biološko enakovredna izpostavljenosti psevdoefedrinijevemu sulfatu po zaužitju tablet zdravila Aerinaze.
English: Cardiovascular and general effects
Slovenian: Učinki na srce in ožilje ter splošni učinki
English: Dihydroergotamine, ergotamine, methylergometrine: risk of vasoconstriction and increase in blood pressure.
Slovenian: Dihidroergotamin, ergotamin, metilergometrin: tveganje za vazokonstrikcijo in zvišan krvni tlak.
English: After oral administration, desloratadine selectively blocks peripheral histamine H1-receptors because the substance is excluded from entry to the central nervous system.
Slovenian: Po peroralni uporabi desloratadin torej selektivno blokira samo periferne histaminske receptorje H1, ker učinkovina ne more prehajati v osrednje živčevje.
English: • Patients with a history of myocardial infarction, diabetes mellitus, bladder neck obstruction, or positive anamnesis of bronchospasm
Slovenian: • pri bolnikih z miokardnim infarktom v pretekli anamnezi, sladkorno boleznijo, obstrukcijo vratu sečnega mehurja ali pozitivno anamnezo bronhospazma,
English: Drinking alcohol while taking Aerinaze is not recommended.
Slovenian: Med jemanjem zdravila Aerinaze pitje alkohola ni priporočljivo.
English: • dry throat
Slovenian: • suho grlo
English: Talk to your doctor, pharmacist or nurse before taking Aerinaze: - if you are 60 years of age or older.
Slovenian: Pred začetkom jemanja zdravila Aerinaze se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro: - če ste stari 60 let ali več.
English: In a single dose pharmacokinetic study with Aerinaze, plasma concentration of desloratadine can be detected within 30 minutes of administration.
Slovenian: V farmakokinetični študiji z uporabo enkratnih odmerkov zdravila Aerinaze so lahko plazemsko koncentracijo desloratadina izmerili že 30 minut po odmerjanju.
English: In addition, the decongestant efficacy of Aerinaze tablets, as measured by nasal stuffiness/congestion, was significantly greater than desloratadine alone over the 2-week treatment period.
Slovenian: Poleg tega je bila dekongestivna učinkovitost zdravila Aerinaze tablete, merjena na podlagi zamašenosti nosa oz. kongestije nosne sluznice, bistveno večja kot pri samem desloratadinu v času 2-tedenskega zdravljenja.
English: Aerinaze is not recommended for use in patients with impaired renal or hepatic function.
Slovenian: Uporaba zdravila Aerinaze ni priporočljiva pri bolnikih z okvarjenim delovanjem ledvic ali jeter.
English: • aggression
Slovenian: • agresivnost
English: 2 modified-release tablets 4 modified-release tablets 7 modified-release tablets 10 modified-release tablets 14 modified-release tablets 20 modified-release tablets
Slovenian: 2 tableti s podaljšanim sproščanjem 4 tablete s podaljšanim sproščanjem 7 tablet s podaljšanim sproščanjem 10 tablet s podaljšanim sproščanjem 14 tablet s podaljšanim sproščanjem 20 tablet s podaljšanim sproščanjem
English: • problems urinating
Slovenian: • težave z uriniranjem
English: Its elimination half-life in humans, at an approximate urinary pH of 6, ranges from 5 to 8 hours.
Slovenian: Razpolovna doba izločanja psevdoefedrinijevega sulfata pri ljudeh pri pH vrednosti seča okoli 6 znaša od 5 do 8 ur.
English: Older adults may be more sensitive to the effects of this medicine - if you have diabetes
Slovenian: Starostniki so lahko bolj občutljivi za učinke tega zdravila.
English: Other symptoms may include: headache, anxiety, micturition difficulty, muscle weakness and tenseness, euphoria, excitement, respiratory failure, cardiac arrhythmias, tachycardia, palpitations, thirst, perspiration, nausea, vomiting, precordial pain, dizziness, tinnitus, ataxia, blurred vision and hypertension or hypotension.
Slovenian: Med druge simptome sodijo na primer glavobol, tesnoba, težave pri uriniranju, mišična šibkost in napetost, evforija, razburjenje, odpoved dihanja, srčne aritmije, tahikardija, palpitacije, žeja, potenje, slabost, bruhanje, prekordialne bolečine, omotica, tinitus, ataksija, zamegljen vid in hipertenzija ali hipotenzija.
English: How to take Aerinaze
Slovenian: Kako jemati zdravilo Aerinaze
English: CNS stimulation is particularly likely in children, as are atropine-like symptoms (dry mouth, fixed and dilated pupils, flushing, hyperthermia, and gastrointestinal symptoms).
Slovenian: Stimulacija osrednjega živčevja je še posebej mogoča pri otrocih, kar velja tudi za atropinskim podobne simptome (suha usta, stalno razširjeni zenici, pordelost, hipertermija in simptomi v prebavilih).
English: The active substance is excreted in breast milk of breast-feeding women.
Slovenian: Učinkovina se izloča v materino mleko pri doječih materah.
English: In both trials, the antihistaminic efficacy of Aerinaze tablets as measured by total symptom score, excluding nasal congestion, was significantly greater than pseudoephedrine sulphate alone over the 2-week treatment period.
Slovenian: V obeh preskušanjih je bila antihistaminska učinkovitost zdravila Aerinaze tablete, merjena na podlagi skupne ocene simptomov brez kongestije nosne sluznice, bistveno večja kot pri uporabi samega psevdoefedrinijevega sulfata za 2-tedensko zdravljenje.
English: Use with caution in patients with stenosing peptic ulcer, pyloroduodenal obstruction, and obstruction of the vesical cervix.
Slovenian: Zdravilo je treba uporabljati previdno tudi pri bolnikih s stenozirajočim peptičnim ulkusom, piloroduodenalno obstrukcijo in obstrukcijo vratu sečnega mehurja.
English: Aerinaze tablets relieve symptoms associated with seasonal allergic rhinitis (hay fever), such as, sneezing, runny or itchy nose, and eyes, when accompanied by nasal congestion in adults and adolescents 12 years of age and older.
Slovenian: Zdravilo Aerinaze tablete lajša simptome, povezane s sezonskim alergijskim rinitisom (senenim nahodom), na primer kihanje, izcedek iz nosu ali srbenje nosu in oči, ki jih spremlja zamašen nos, pri odraslih in mladostnikih, starih 12 let in več.
English: The blister consists of clear polychlorotrifluorethylene/polyvinyl chloride (PCTFE/PVC) film, sealed with a vinyl heat seal coated aluminium foil.
Slovenian: Pretisni omot sestoji iz prozorne folije iz poliklorotrifluoretilena in polivinilklorida (PCTFE/PVC), ki je zavarjena z aluminijasto folijo, prevlečeno z vinilno termoskrčljivo prevleko.
English: Adverse reactions seen with Aerinaze
Slovenian: Neželeni učinki, ki so jih opazili pri zdravilu Aerinaze
English: Continuous use can lead to tolerance resulting in an increased risk of overdosing.
Slovenian: Neprekinjena uporaba lahko vodi do nastanka tolerance, ki pomeni večje tveganje, da bo prišlo do prevelikega odmerjanja zdravila, po nagli ukinitvi zdravila pa lahko nastopi depresija.
English: No significant differences were found in the psychomotor test results between desloratadine and placebo groups, whether administered alone or with alcohol.
Slovenian: Rezultati psihomotoričnih testov niso pokazali bistvenih razlik med skupino, ki je prejemala desloratadin, in skupino, ki je prejemala placebo, ne glede na to, ali so preiskovanci zdravilo jemali samostojno ali skupaj z alkoholom.
English: • Patients with hypertension
Slovenian: • pri bolnikih s hipertenzijo,
English: One of the active ingredients in Aerinaze, pseudoephedrine sulphate, has the potential to be abused and large doses of pseudoephedrine sulphate can be toxic.
Slovenian: Ena od učinkovin v zdravilu Aerinaze, psevdoefedrinijev sulfat, bi lahko vodila k zlorabi tega zdravila, veliki odmerki psevdoefedrinijevega sulfata pa so lahko škodljivi.
English: These include inhibiting the release of proinflammatory cytokines such as IL-4, IL-6, IL-8, and IL-13 from human mast cells/basophils, as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells.
Slovenian: V študijah in vitro je desloratadin pokazal antialergijsko delovanje, na primer zaviranje sproščanja vnetnih citokinov, kot so IL-4, IL-6, IL-8 in IL-13, iz človeških mastocitov ali bazofilcev, pa tudi zaviranje ekspresije adhezijske molekule selektina P na endotelijskih celicah.
English: This is due to the alpha-mimetic activity of pseudoephedrine sulphate in combination with other vasoconstrictors such as bromocripitine, pergolide, lisuride, cabergoline, ergotamine, dihydroergotamine or any other decongestant medicinal product used as a nasal decongestant, either by oral route or by nasal route (phenylpropanolamine, phenylephrine, ephedrine, oxymetazoline, naphazoline…).
Slovenian: To je posledica alfa-mimetične aktivnosti psevdoefedrinijevega sulfata v kombinaciji z drugimi vazokonstriktorji, na primer z bromokripitinom, pergolidom, lizuridom, kabergolinom, ergotaminom, dihidroergotaminom ali katerimkoli drugim dekongestivom, ki se uporablja kot nosni dekongestiv, bodisi po peroralni ali po nazalni poti (fenilpropanolamin, fenilefrin, efedrin, oksimetazolin, nafazolin itn.).
English: Fertility There is no data available on male/female fertility.
Slovenian: Plodnost O vplivu na plodnost pri moških/ženskah ni podatkov.
English: • inflammation of the nose
Slovenian: • krvavitev iz nosu
English: Other vasoconstrictors used as nasal decongestant, by oral or nasal route (phenylpropanolamine, phenylephrine, ephedrine, oxymetazoline, naphazoline…): risk of vasoconstriction.
Slovenian: Drugi vazokonstriktorji, ki se uporabljajo kot nazalni dekongestivi po peroralni ali nazalni poti (fenilpropanolamin, fenilefrin, efedrin, oksimetazolin, nafazolin...): tveganje za vazokonstrikcijo.
English: White, sustained-release layer hypromellose 2208 microcrystalline cellulose povidone K30 silicon dioxide magnesium stearate.
Slovenian: Bela plast za podaljšano sproščanje hipromeloza 2208 mikrokristalna celuloza povidon K30 silicijev dioksid magnezijev stearat
English: No interaction studies have been performed with the combination of desloratadine and pseudoephedrine sulphate.
Slovenian: Študij medsebojnega delovanja kombinacije desloratadina in psevdoefedrinijevega sulfata niso izvedli.
English: Hypertension can be controlled with an adrenoceptor-blocking agent and tachycardia with a beta-blocking agent.
Slovenian: Hipertenzijo boste lahko obvladali z uporabo zaviralca adrenergičnih receptorjev, tahikardijo pa z zaviralcem receptorjev beta.
English: • restlessness with increased body movement
Slovenian: • nemir s povečanimi telesnimi gibi
English: The half-life for desloratadine is 27.4 hours.
Slovenian: Razpolovna doba desloratadina znaša 27,4 ur, navidezna razpolovna doba psevdoefedrinijevega sulfata pa je 7,9 ur.
English: However, non-clinical data with desloratadine reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction and development.
Slovenian: Vendar pa predklinični podatki o desloratadinu na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih odmerkih, genotoksičnosti, kancerogenega potenciala, vpliva na sposobnost razmnoževanja in razvoja ne kažejo posebnega tveganja za človeka.