FrancophonIA/ELRC3.0 huggingface dataset:
English: Possia reduced the occurrence of the primary composite endpoint compared to clopidogrel in both the UA/NSTEMI and STEMI population (Table 3).
Danish: Figur 1 - Tid indtil første forekomst af kardiovaskulært dødsfald, MI og apopleksi (PLATO) Possia reducerede forekomsten af det primære sammensatte endepunkt sammenlignet med clopidogrel i både UA/NSTEMI- og STEMI-populationen (tabel 3).
English: Possia is expected to have no or negligible influence on the ability to drive and use machines.
Danish: Possia påvirker efter forventning ikke eller i ubetydelig grad evnen til at føre motorkøretøj eller betjene maskiner.
English: What Possia looks like and contents of the pack Film-coated tablet (tablet): The tablets are round, biconvex, yellow, film-coated marked with a “90”
Danish: Filmovertrukket tablet (tablet): Tabletterne er runde, bikonvekse, gule, filmovertrukne, præget med "90" over "T" på den ene side.
English: In the PLATO study, Possia was commonly administered with ASA, proton pump inhibitors, statins, beta-blockers, angiotensin converting enzyme inhibitors and angiotensin receptor blockers as needed for concomitant conditions for long-term and also heparin, low molecular weight heparin and intravenous GpIIb/IIIa inhibitors for short durations (see section 5.1).
Danish: I PLATO-studiet blev Possia ofte administreret sammen med ASA, syrepumpehæmmere, statiner, betablokkere, angiotensinkonverterende enzymhæmmere og angiotensin II-receptorantagonister efter behov for samtidige sygdomme gennem længere tid og ligeledes sammen med heparin, lavmolekylært heparin og intravenøse GpIIb/IIIa-hæmmere i kortere tid (se pkt.
English: Patients with acute coronary syndromes treated with Possia and ASA showed an increased risk of non-CABG major bleeding and also more generally in bleeds requiring medical attention i.e. Major + Minor PLATO bleeds, but not Fatal or Life-threatening bleeds (see section 4.8).
Danish: Patienter med akut koronarsyndrom, som blev behandlet med Possia og ASA, havde en øget risiko for ikke-koronar bypass relaterede blødninger (non CABG related bleeds), og også mere generelt for blødninger, der krævede medicinsk behandling, dvs. de blødninger man i studiet definerede som større + mindre PLATO blødninger (Major + Minor PLATO bleeds), men ikke fatale eller livstruende blødninger (Fatal or Lifethreatening bleeds) (se pkt.
English: This reduces the chance of a blood clot forming that can
Danish: Dette reducerer risikoen for dannelsen af en blodprop, der kan nedsætte blodgennemstrømningen.
English: In PLATO patients undergoing coronary artery bypass grafting (CABG), Possia had more bleeding than clopidogrel when stopped within 1 day prior to surgery but a similar rate of major bleeds compared to clopidogrel after stopping therapy 2 or more days before surgery (see section 4.8).
Danish: Hos PLATO-patienter, der fik foretaget koronar bypassoperation (CABG), havde Possia flere blødninger end clopidogrel, når behandlingen blev seponeret inden for et døgn før indgrebet, men samme incidens af større blødninger sammenlignet med clopidogrel efter seponering af behandlingen to eller flere dage før indgrebet (se pkt.
English: Retroperitoneal haemorrhage, Constipation
Danish: Retroperitoneal blødningb Obstipation
English: clarithromycin, nefazodone, ritonavir, and atazanavir) is contraindicated, as co-administration may lead to a substantial increase in exposure to ticagrelor (see section 4.4 and 4.5).
Danish: clarithromycin, nefazodon, ritonavir og atazanavir) er kontraindiceret, da det kan medføre en væsentlig stigning i eksponeringen af ticagrelor (se pkt.
English: Possia contains ticagrelor a member of the chemical class cyclopentyltriazolopyrimidines (CPTP), which is a selective adenosine diphosphate (ADP) receptor antagonist acting on the P2Y12
Danish: Possia indeholder ticagrelor, som tilhører den kemiske gruppe CPTP (cyklopentyltriazolopyrimidiner), som er en selektiv adenosindifosfat (ADP)-receptorblokker, der virker på P2Y12 ADP-receptoren, der kan forebygge ADP-medieret trombocytaktivering og -aggregation.
English: No clinically relevant effect on oral contraceptive efficacy is expected when levonorgestrel and ethinyl estradiol are
Danish: Der forventes ingen klinisk relevant indvirkning på p-pillers virkning, når levonorgestrel og ethinylestradiol administreres samtidig med Possia.
English: What Possia is and what it is used for
Danish: Hvad Possia anvendes til
English: PLATO included patients with baseline congestive heart failure, chronic obstructive pulmonary disease, or asthma; these patients, and the elderly, were more likely to report dyspnoea.
Danish: PLATO inkluderede patienter, der ved baseline led af kongestiv hjerteinsufficiens, kronisk obstruktiv lungesygdom eller astma.
English: • PVC-PVDC/Al transparent calendar blister (with sun/moon symbols) of 14 tablets; cartons of 14 tablets (1 blister), 56 tablets (4 blisters), and 168 tablets (12 blisters).
Danish: • PVC-PVDC/Al gennemsigtige kalender-blisterkort (med sol/måne-symbol) a 14 tabletter i æsker med 14 tabletter (1 blisterkort), 56 tabletter (4 blisterkort) og 168 tabletter
English: However, due to potential pharmacodynamic interactions, caution should be exercised with the concomitant administration of Possia with medicinal products known to alter haemostasis (see section 4.4).
Danish: På grund af potentiel farmakodynamiske interaktioner tilrådes dog forsigtighed under samtidig administration af Possia og lægemidler, der vides at ændre hæmostasen (se pkt.
English: Major Other: Clinically apparent with 30-50 g/l decrease in haemoglobin or 2-3 red cell units transfused; or significantly disabling.
Danish: Major Other: Klinisk åbenbar med en reduktion på 30-50 g/l af hæmoglobin eller 2-3 infunderede erytocytenheder eller svært invaliderende.
English: In the presence of digoxin, the Cmax and AUC of ticagrelor and its active metabolite were not affected.
Danish: Der var ingen indvirkning på Cmax og AUC for ticagrelor og dets aktive metabolit under forekomst af digoxin.
English: Caution should be exercised when administering ticagrelor to patients with history of hyperuricaemia or gouty arthritis.
Danish: Der skal udvises forsigtighed, når ticagrelor administreres til patienter med en anamnese med hyperurikæmi eller podagra.
English: • standard blisters (with sun/moon symbols) in cartons of 60 and 180 tablets
Danish: • Standardblisterkort (med sol/måne-symbol) i æsker med 60 og 180 tabletter
English: However no evidence of clinically significant adverse reactions was observed in the PLATO trial after concomitant administration with one or more medicinal products known to induce bradycardia (e.g., 96% beta blockers, 33% calcium channel blockers diltiazem and verapamil, and 4% digoxin).
Danish: Der var imidlertid ingen evidens af klinisk signifikante bivirkninger i PLATO-studiet efter samtidig administration af ét eller flere lægemidler, kendt for at inducere bradykardi (f.eks. 96 % betablokkere, 33 % calciumantagonister diltiazem og verapamil, og 4 % digoxin).
English: No dose adjustment is necessary for patients with renal impairment (see section 5.2).
Danish: Dosisjustering er ikke nødvendig for patienter med nyreinsufficiens (se pkt.
English: Respiratory, thoracic and mediastinal disorders e, Haemorrhoidal
Danish: Luftveje, thorax og mediastinum Dyspnøc
English: • PVC-PVDC/Al transparent blister (with sun/moon symbols) of 10 tablets; cartons of 60 tablets (6 blisters) and 180 tablets (18 blisters).
Danish: • PVC-PVDC/Al gennemsigtige blisterkort (med sol/måne-symbol) a 10 tabletter i æsker med 60 tabletter (6 blisterkort) og 180 tabletter (18 blisterkort).
English: Suomi/Finland AstraZeneca Oy Puh/Tel: + 358 10 23 010
Danish: AstraZeneca Oy Puh/Tel: + 358 10 23 010
English: Detailed information on this medicine is available on the European Medicines Agency web site:
Danish: Yderligere information om dette lægemiddel er tilgængelig på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu.
English: Possia reduces the chances of you having another heart attack or a stroke or of dying from a disease related to your heart or blood vessels.
Danish: Possia reducerer risikoen for, at du får en ny blodprop i hjertet eller et slagtilfælde, eller for at du dør som følge af hjertekarsygdom.
English: Do not take Possia if:
Danish: Possia fås i:
English: The treatment effect of ticagrelor over clopidogrel appears consistent across many subgroups, including weight; sex; medical history of diabetes mellitus, transient ischaemic attack or nonhaemorrhagic stroke, or revascularisation; concomitant therapies including heparins, GpIIb/IIIa inhibitors and proton pump inhibitors (see section 4.5); final index event diagnosis (STEMI, NSTEMI, or UA); and, treatment pathway intended at randomisation (invasive or medical).
Danish: Effekten af behandling med ticagrelor i forhold til clopidogrel synes at være konsistent på tværs af mange undergrupper, herunder vægt; køn; anamnese med diabetes mellitus, transitorisk iskæmisk attak eller non-hæmoragisk insult eller revaskularisering; samtidige behandlinger herunder hepariner, GpIIb/IIIa-hæmmere og syrepumpehæmmere (se pkt.
English: Ticagrelor had no effect on male or female fertility in animals (see section 5.3).
Danish: Fertilitet Ticagrelor havde ingen indvirkning på fertiliteten hos han- og hundyr i dyreforsøg (se pkt.
English: Taking Possia with food and drink
Danish: Brug af Possia sammen med mad og drikke Du kan tage Possia med eller uden mad.
English: • calendar blisters (with sun/moon symbols) in cartons of 14, 56 and 168 tablets
Danish: • Kalenderblisterkort (med sol/måne-symbol) i æsker med 14, 56 og 168 tabletter
English: • Moderate CYP3A4 inhibitors - Co-administration of diltiazem with ticagrelor increased the ticagrelor Cmax by 69% and AUC to 2.7 fold and decreased the active metabolite Cmax by 38% and AUC was unchanged.
Danish: • Moderate CYP3A4-hæmmere - Samtidig administration af diltiazem og ticagrelor øgede ticagrelors Cmax med 69 % og AUC 2,7 gange og reducerede den aktive metabolits Cmax med 38 %.
English: However no evidence of clinically significant adverse reactions was observed in the PLATO trial after concomitant administration with one or more medicinal products known to induce bradycardia (e.g., 96% beta blockers, 33% calcium channel blockers diltiazem and verapamil, and 4% digoxin) (see section 4.5).
Danish: Der var dog ingen evidens af klinisk signifikante bivirkninger i PLATOstudiet efter samtidig administration af et eller flere lægemidler, der er kendt for at inducere bradykardi (f.eks. 96 % betablokkere, 33 % calciumantagonister (diltiazem og verapamil) og 4 % digoxin) (se pkt.
English: NAME OF THE MARKETING AUTHORISATION HOLDER
Danish: INDEHAVER AF MARKEDSFØRINGSTILLADELSEN
English: - If you have any further questions, ask your doctor or pharmacist.
Danish: Er du i tvivl, så spørg lægen eller på apoteket.
English: Possia is not likely to affect your ability to drive or use machines.
Danish: Trafik- og arbejdssikkerhed Possia vil sandsynligvis ikke påvirke din evne til at køre eller betjene værktøj eller maskiner.
English: Chronic daily ASA doses to accompany Possia should be 75-150 mg (see section 4.2 and 4.4).
Danish: Kroniske daglige ASA-doser i kombination med Possia bør være 75-150 mg (se pkt.
English: • You are taking any of the following medicines: ketoconazole (used to treat fungal infections), clarithromycin (used to treat bacterial infections), nefazodone (an antidepressant), ritonavir and atazanavir (used to treat HIV infection and AIDS).
Danish: • hvis du tager et af disse lægemidler: ketoconazol (mod svampeinfektioner), clarithromycin (mod infektioner der skyldes bakterier), nefazodon (mod depression), ritonavir og atazanavir (mod hiv-infektion og aids).
English: Co-administration of ticagrelor with strong CYP3A4 inducers (e.g. rifampicin, dexamethasone, phenytoin, carbamazepine and phenobarbital) is discouraged, as co-administration may lead to a decrease in exposure and efficacy of ticagrelor (see section 4.5).
Danish: Samtidig administration af ticagrelor og stærke CYP3A4-induktorer (f.eks. rifampicin, dexamethason, phenytoin, carbamazepin og phenobarbital) frarådes, da samtidig administration kan føre til et fald i eksponeringen for og virkningen af ticagrelor (se pkt.
English: Ticagrelor has not been evaluated in a paediatric population (see section 4.2 and 5.1).
Danish: Pædiatrisk population Ticagrelor er ikke blevet vurderet i en pædiatrisk population (se pkt.
English: If clinically indicated, medicinal products that alter haemostasis should be used with caution in combination with Possia (see section 4.4).
Danish: Hvis det er klinisk indiceret, tilrådes forsigtighed ved anvendelse af lægemidler, der ændrer hæmostasen, i kombination med Possia (se pkt.
English: This includes medicines that you buy without a prescription, dietary supplements and herbal remedies.
Danish: Dette gælder også medicin, som ikke er købt på recept, f,eks.
English: Elderly patients No dose adjustment is required in elderly (see section 5.2).
Danish: Ældre patienter Dosisjustering er ikke nødvendig for ældre patienter (se pkt.
English: Table 2 -Kaplan-Meier estimate of bleeding rates by treatment
Danish: Tabel 2 - Kaplan-Meier vurdering af blødningshyppigheder efter behandling Possia (%/år) N=9235
English: No data are available on concomitant use of Possia with potent P-glycoprotein (P-gp) inhibitors (e.g. verapamil, quinidine, cyclosporin) that may increase ticagrelor exposure.
Danish: Der foreligger ingen data om samtidig anvendelse af Possia og potente P-glykoprotein- (P-gp-) hæmmere (f.eks. verapamil, quinidin, ciclosporin), som kan øge eksponeringen for ticagrelor.
English: This can be
Danish: Hvad Possia er
English: No data are available on concomitant use of Possia with potent P-gp inhibitors (e.g. verapamil, quinidine, cyclosporin) that may increase ticagrelor exposure.
Danish: Der foreligger ingen data om samtidig anvendelse af Possia og potente P-gp-hæmmere (f.eks. verapamil, quinidin, ciclosporin), som kunne øge eksponeringen for ticagrelor.
English: Co-administration of Possia with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, nefazodone, ritonavir, and atazanavir) is contraindicated (see section 4.3 and 4.5).
Danish: Samtidig administration af Possia og stærke CYP3A4-hæmmere (f.eks. ketoconazol, clarithromycin, nefazodon, ritonavir og atazanavir) er kontraindiceret (se pkt.
English: PERFORATED UNIT DOSE BLISTER (100X1 TABLETS)
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP Perforeret enkeltdosisblister (100x1 tabletter)
English: This dose will usually be given to you in the hospital.
Danish: Du vil sædvanligvis få denne
English: The concomitant use of Possia with doses of simvastatin or lovastatin greater than 40 mg is not recommended (see section 4.4).
Danish: Possia bør ikke anvendes samtidig med simvastatin- eller lovastatin-doser, der overstiger 40 mg (se pkt.
English: CONDITIONS OR RESTRICTIONS REGARDING SUPPLY
Danish: B. BETINGELSER ELLER BEGRÆNSNINGER VEDRØRENDE UDLEVERING OG
English: The hyperuricaemia AEs reported were 0.5% for ticagrelor vs. 0.2% for clopidogrel.
Danish: Der blev rapporteret hændelser af hyperurikæmi hos 0,5 % af ticagrelor-patienterne vs. hos 0,2 % af clopidogrel-patienterne.
English: Injury, poisoning and procedural complications
Danish: Traumer, forgiftninger og behandlingskomplikationer Blødning fra indstiksstedi
English: - recent surgery (including dental work) - you have a condition that affects blood clotting - recent bleeding from your stomach or gut (such as a stomach ulcer or colon ‘polyps')
Danish: - at du har en lidelse, der påvirker blodets evne til at størkne - en nylig blødning fra maven eller tarmene (som f.eks. et mavesår eller udposninger på
English: For gouty arthritis, the AEs reported were 0.2% for ticagrelor vs 0.1% for clopidogrel; none of these adverse events were assessed as
Danish: Med hensyn til podagra var der indberettet hændelser hos 0,2 % af ticagrelorpatienterne vs 0,1 % af clopidogrel-patienterne; ingen af disse hændelser blev af investigatorerne betragtet som kausalt relaterede.
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 (see
Danish: • Overfølsomhed over for det aktive stof eller over for et eller flere af hjælpestofferne anført i pkt.
English: Other strong inhibitors of CYP3A4 (clarithromycin, nefazodone, ritonavir, and atazanavir) would be expected to have similar effects and their concomitant use with Possia is contraindicated (see section 4.3 and 4.4).
Danish: Andre stærke hæmmere af CYP3A4 (clarithromycin, nefazodon, ritonavir og atazanavir) kan forventes at have en lignende virkning, og samtidig behandling med Possia er kontraindiceret (se pkt.
English: Co-administration of ticagrelor with potent CYP3A inducers may decrease exposure and efficacy of ticagrelor (see section 4.4).
Danish: Samtidig administration af ticagrelor og potente CYP3Ainduktorer kan øge eksponeringen for ticagrelor og dets virkning (se pkt.
English: - This medicine has been prescribed for you only.
Danish: - Lægen har ordineret Possia til dig personligt.
English: NAME OF THE MEDICINAL PRODUCT
Danish: Medicin plan
English: The safety of Possia in patients with acute coronary syndromes (UA, NSTEMI and STEMI) was evaluated in the pivotal large phase 3 PLATO ([PLATelet Inhibition and Patient Outcomes] study, 18,624 patients), which compared patients treated with Possia (loading dose of 180 mg of Possia and a maintenance dose of 90 mg twice daily) to patients treated with clopidogrel (300-600 mg loading dose followed by 75 mg once daily maintenance dose) both given in combination with acetylsalicylic acid (ASA) and other standard therapies.
Danish: Sikkerheden af Possia hos patienter med akut koronarsyndrom (UA, NSTEMI og STEMI) blev vurderet i den pivotale, store fase 3-studie PLATO ([PLATelet Inhibition and Patient Outcomes], 18.624), som sammenlignede patienter, der blev behandlet med Possia (mætningsdosis på 180 mg
English: Tablet film coating: hypromellose (E464), titanium dioxide (E171), talc, polyethylene-glycol 400, and ferric oxide yellow (E172).
Danish: Tablettens filmovertræk: hypromellose (E464), titandioxid (E171), talcum,
English: Co-administration of Possia and CYP3A4 substrates with narrow therapeutic indices (i.e., cisapride and ergot alkaloids) is not recommended, as ticagrelor may increase the exposure to these medicinal products (see section 4.5).
Danish: Samtidig administration af Possia og CYP3A4-substrater med snævert terapeutisk indeks (dvs. cisaprid og sekalealkaloider) frarådes, da ticagrelor kan øge eksponeringen for disse lægemidler (se pkt.
English: Post procedural haemorrhage, Haemorrhage
Danish: Blødning post procedure
English: Uncommon (affects 1 to 10 users in 1,000)
Danish: Ikke almindelige (forekommer hos mellem 1 og 10 ud af 1.000 patienter):
English: Paraesthesia
Danish: Dyspepsi
English: MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Danish: FREMSTILLERENS BATCHNUMMER Lot
English: Possia 90 mg film-coated tablets ticagrelor
Danish: Possia 90 mg filmovertrukne tabletter ticagrelor
English: If clinically indicated, their concomitant use should be made with caution (see section 4.4).
Danish: Hvis det er klinisk indiceret, kan de anvendes samtidig med forsigtighed (se pkt.
English: Possia does not affect tests of
Danish: Possia påvirker ikke tests af lungefunktionen.
English: BLISTER (10 TABLETS)
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP Blister (10 tabletter)
English: This will tell you whether you have taken the
Danish: Så kan du nemt se, om du har taget tabletten.
English: This is uncommon.
Danish: Ikke almindelige
English: For any information about this medicine, please contact the local representative of the Marketing
Danish: Hvis du vil have yderligere oplysninger om Possia, skal du henvende dig til den lokale repræsentant:
English: Each film-coated tablet contains 90 mg of ticagrelor.
Danish: Hver filmovertrukken tablet indeholder 90 mg ticagrelor.
English: Marketing Authorisation Holder: AstraZeneca AB S-151 85
Danish: Indehaver af markedsføringstilladelsen: AstraZeneca AB
English: However, more PLATO combined Major + Minor bleeding occurred with ticagrelor compared with clopidogrel.
Danish: Der forekom dog flere kombinerede Major + Minor bleeding iht.
English: There were no reported ADRs of haemarthrosis reported in the ticagrelor arm (n=9235) of the PLATO study, the frequency has been calculated using the upper limit of the 95% confidence interval for the point estimate (based on 3/X, where X represents the total sample size e.g. 9235).
Danish: Blødning fra blodkar ved indstikssted, hæmatom fra blodkar ved indstikssted, blødning fra injektionssted, blødning fra indstikssted, blødning fra kateteranlæggelsessted Der blev ikke indberettet bivirkninger i form af hæmartrose i ticagrelor-armen (n=9235) i PLATOstudien, og hyppigheden blev beregnet ved hjælp af den øvre grænse for 95 % konfidensintervallet for punktestimatet (baseret på 3/X, hvor X repræsenterer hele sample size, f.eks. 9235).
English: AstraZeneca S.p.A. Tel: + 39 02 98011
Danish: Tel: + 39 02 98011
English: 6.6 Special precautions for disposal
Danish: 6.4 Særlige opbevaringsforhold
English: • Rash
Danish: • Kløe
English: Its use in patients with moderate to severe hepatic impairment is therefore contraindicated (see section 4.3, 4.4 and 5.2).
Danish: Anvendelse af Possia til patienter med moderat til svært nedsat leverfunktion er derfor kontraindiceret (se pkt.
English: Close clinical and laboratory monitoring is recommended when giving digoxin concomitantly with
Danish: Nøje klinisk observation og kontrol af labroatorieværdier anbefales ved samtidig anvendelse af digoxin og Possia (se pkt.
English: Preclinical data for ticagrelor and its major metabolite have not demonstrated unacceptable risk for adverse effects for humans based on conventional studies of safety pharmacology, single and repeated dose toxicity and genotoxic potential.
Danish: Dette baseres på konventionelle undersøgelser af sikkerhedsfarmakologi, toksicitet ved enkeltdosis og gentagne doseringer samt genotoksisk potentiale.
English: Creatinine elevations by >50% were more pronounced in patients > 75 years (ticagrelor 13.6% versus clopidogrel 8.8%), in patients with severe renal impairment at baseline (ticagrelor 17.8% versus clopidogrel 12.5%) and in patients receiving concomitant treatment with ARBs (ticagrelor 11.2% versus clopidogrel 7.1%).
Danish: ), hos patienter med svært nedsat nyrefunktion ved baseline (ticagrelor 17,8 % versus clopidogrel 12,5 %) og hos patienter, der var i samtidig behandling med antiogensin II-receptorantagonist (ticagrelor 11,2 % versus clopidogrel 7,1 %).
English: • perforated blisters in a carton of 100x1 tablets
Danish: • Perforerede blisterkort i æsker med 100x1 tabletter Ikke alle pakningsstørrelser er nødvendigvis markedsført.
English: • other medicines such as ketoconazole (used to treat fungal infections), clarithromycin (used to treat bacterial infections), nefazodone, (an antidepressant), ritonavir and atazanavir (used to treat HIV infection and AIDS), cisapride (used to treat heartburn), ergot alkaloids (used to treat migraines and headaches).
Danish: • Anden medicin såsom ketoconazol (mod svampeinfektioner), clarithromycin (mod bakterielle infektioner), nefazodon (mod depression), ritonavir og atazanavir (mod hiv-infektion og aids),
English: Co-administration of Possia and CYP3A4 substrates with narrow therapeutic indices (i.e., cisapride or ergot alkaloids) is not recommended, as ticagrelor may increase the exposure to these medicinal products (see section 4.4).
Danish: Possia bør ikke administreres samtidig med CYP3A4substrater med snævert terapeutisk indeks (f.eks. cisaprid eller sekalealkaloider), da ticagrelor kan øge eksponeringen for disse lægemidler (se pkt.