FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients should be re-treated only when neutrophils recover to a level ≥1,500/mm3 (see section 4.3).
Danish: Patienter bør kun genbehandles, når neutrofiltallet vender tilbage til et niveau ≥1.500/mm3 (se pkt.
English: In vitro cabazitaxel did not inhibit Multidrug-Resistant Proteins (MRP): MRP1 and MRP2 or Organic Cation Transporter (OCT1).
Danish: In vitro hæmmede cabazitaxel ikke Multidrug-Resistance Proteiner (MRP): MRP1 og MRP2 eller organisk kation-transportør (OCT1).
English: Number of patients with dose reduction n (%)
Danish: Antal patienter, der fik dosisreduktion n (%)
English: One patient in the cabazitaxel group died from cardiac failure.
Danish: En patient i cabazitaxel-gruppen døde af hjertesvigt.
English: Patients treated with cabazitaxel may receive prophylactic G-CSF, as per American Society of Clinical Oncology (ASCO) guidelines and/or current institutional guidelines, to reduce the risk or manage neutropenia complications (febrile neutropenia, prolonged neutropenia or neutropenic infection).
Danish: Patienter behandlet med cabazitaxel kan modtage profylaktisk G-CSF i henhold til retningslinjerne fra American Society of Clinical Oncology (ASCO) og/eller gældende lokale retningslinjer for at mindske risikoen for, eller håndtere neutropenikomplikationer (febril neutropeni, langvarig neutropeni eller neutropenisk infektion).
English: During treatment with JEVTANA, it is more likely that your white blood cell count may be reduced.
Danish: Under behandlingen med JEVTANA er det sandsynligt, at det antal hvide blodlegemer, som du har i kroppen, reduceres.
English: Anaemia a
Danish: Neutropenia* Anæmi a
English: MARKETING AUTHORISATION NUMBER(S) EU/1/11/676/001
Danish: EU/1/11/676/001
English: Safety and effectiveness of JEVTANA have not been established in children and adolescents below 18 years of age.
Danish: JEVTANAs sikkerhed og virkning hos børn og unge under 18 år er ikke klarlagt.
English: 4.4 Special warnings and precautions for use
Danish: 4.4 Særlige advarsler og forholdsregler vedrørende brugen
English: Other laboratory abnormalities
Danish: Andre laboratorieabnormiteter
English: Around 20 metabolites of cabazitaxel are excreted into human urine and faeces.
Danish: Ca. 20 metabolitter af cabazitaxel udskilles i human urin og fæces.
English: Serum creatinine should be measured at baseline, with each blood count and whenever the patient reports a change in urinary output.
Danish: Serumkreatinin skal måles før behandlingsstart (baseline), i forbindelse med hver blodtælling, og når som helst patienten rapporterer en ændring i vandladningsmængden.
English: Cabazitaxel treatment delay or discontinuation may be necessary.
Danish: Udsættelse eller afbrydelse af behandling med cabazitaxel kan være nødvendig.
English: Cystitis due to radiation recall phenomenon, including haemorrhagic cystitis, were reported uncommonly.
Danish: Cystitis, som skyldes radiation recall fænomen herunder hæmoragisk cystitis, er rapporteret som ikke almindelig.
English: Treatment delay or dose reduction may be necessary for grade ≥3 diarrhoea (see section 4.2).
Danish: Udsættelse af behandlingen eller dosisreduktion kan være nødvendig ved diarré af grad ≥3 (se pkt.
English: Cabazitaxel is mainly bound to human serum albumin (82.0%) and lipoproteins (87.9% for HDL, 69.8% for LDL, and 55.8% for VLDL).
Danish: Cabazitaxel er først og fremmest bundet til humant serumalbumin (82,0 %) og lipoproteiner (87,9 % for HDL, 69,8 % for LDL og 55,8 % for VLDL).
English: After final dilution in the infusion bag/bottle
Danish: Efter endelig fortynding i infusionsposen/glasset
English: Facilities and equipment for the treatment of serious hypersensitivity reactions like hypotension and bronchospasm must be available (see section 4.4).
Danish: Faciliteter og udstyr til behandling af alvorlige allergiske reaktioner såsom hypotension og bronkospasme skal være til rådighed (se pkt.
English: • severe stomach pain or stomach pain that doesn't go away.
Danish: • alvorlige mavesmerter eller mavesmerter, der ikke går over.
English: If you are not sure, talk to your doctor before having JEVTANA.
Danish: Er du i tvivl, så spørg din læge, inden du får JEVTANA.
English: Haemoglobin and haematocrit should be checked before treatment with cabazitaxel and if patients exhibit signs or symptoms of anaemia or blood loss.
Danish: Hæmoglobin og hæmatokrit skal kontrolleres før behandling med cabazitaxel og hvis patienter udviser tegn eller symptomer på anæmi eller blodmangel.
English: Cabazitaxel binds to tubulin and promotes the assembly of tubulin into microtubules while simultaneously inhibiting their disassembly.
Danish: Cabazitaxel binder til tubulin og fremmer samlingen af tubulin i mikrotubuli samtidig med, at det hæmmer deres adskillelse.
English: After a 1-hour intravenous infusion [14C]-cabazitaxel at 25 mg/m2 in patients, approximately 80% of the administered dose was eliminated within 2 weeks.
Danish: Efter en 1-times intravenøs [14C]-cabazitaxel-infusion ved 25 mg/m2 hos patienter, blev ca. 80 % af den indgivne dosis elimineret inden for 2 uger.
English: • feeling tired, weak or lack of energy.
Danish: • træthed, mathed eller mangel på energi.
English: Cabazitaxel is the main circulating compound in human plasma.
Danish: Cabazitaxel er den primære cirkulerende forbindelse i humant plasma.
English: Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Danish: Inden for hver kategori, er bivirkningerne listet efter aftagende alvorlighed.
English: From a microbiological point of view, the concentrate-solvent mixture should be used immediately.
Danish: Fra et mikrobiologisk synspunkt skal koncentrat-solvens-blandingen anvendes med det samme.
English: Primary prophylaxis with G-CSF should be considered in patients with high-risk clinical features (age >65 years, poor performance status, previous episodes of febrile neutropenia, extensive prior radiation ports, poor nutritional status, or other serious comorbidities) that predispose them to increased complications from prolonged neutropenia.
Danish: Primær profylakse med G-CSF bør overvejes hos høj-risiko patienter (alder > 65 år, dårlig performance status, tidligere episoder med febril neutropeni, omfattende tidligere strålefelter, dårlig ernæringsstatus eller andre alvorlige komorbiditeter), der gør dem modtagelige for komplikationer ved langvarig neutropeni.
English: Based on in vitro studies, the potential risk of inhibition by cabazitaxel at clinically relevant concentrations is possible towards medicinal products that are mainly substrate of CYP3A.
Danish: På basis af in vitro studier er der muligvis en potentiel risiko for at cabazitaxel ved klinisk relevante koncentrationer inhiberer lægemidler, som hovedsagelig er substrater af CYP3A.
English: • skin feeling hot or flushed
Danish: • følelse af varme eller blussende hud
English: Concomitant medicinal products use
Danish: Samtidig anvendelse af andre lægemidler
English: A sub-group of 59 patients received prior cumulative dose of docetaxel <225 mg/m² (29 patients in JEVTANA arm, 30 patients in mitoxantrone arm).
Danish: En undergruppe på 59 patienter havde modtaget en kumulativ dosis af docetaxel <225 mg/m2 (29 patienter i JEVTANA-armen, 30 patienter i mitoxantron-armen).
English: Discontinuation of treatment due to adverse reactions occurred in 68 patients (18.3%) receiving cabazitaxel.
Danish: Behandlingsafbrydelse på grund af bivirkninger forekom hos 68 patienter (18,3 %), som modtog cabazitaxel.
English: Carcinogenicity studies have not been conducted with cabazitaxel.
Danish: Der er ikke udført karcinogenicitetsstudier med cabazitaxel.
English: Cabazitaxel is minimally excreted via the kidney (2.3% of the dose).
Danish: Cabazitaxel udskilles minimalt gennem nyren (2,3 % af dosen).
English: All patients should be pre-medicated prior to the initiation of the infusion of cabazitaxel (see section 4.2).
Danish: Alle patienter skal præmedicineres, inden infusionen af cabazitaxel påbegyndes (se pkt.
English: • pain in mouth or throat
Danish: • smerter i munden eller halsen
English: Respiratory disorders
Danish: Respiratoriske sygdomme
English: Cabazitaxel is mainly excreted in the faeces as numerous metabolites (76% of the dose); while renal excretion of cabazitaxel and metabolites account for less than 4% of the dose (2.3% as unchanged medicinal product in urine).
Danish: Cabazitaxel udskilles hovedsageligt i fæces som adskillige metabolitter (76 % af dosen), mens renal udskillelse af cabazitaxel og metabolitter udgør mindre end 4 % af dosen (2,3 % som uomdannet lægemiddel i urinen).
English: Overall survival was significant longer with JEVTANA compared to mitoxantrone (15.1 months versus 12.7 respectively), with a 30% reduction in the risk of death compared to mitoxantrone (see table 3 and figure 1).
Danish: Den samlede overlevelse var signifikant længere med JEVTANA sammenlignet med mitoxantron (henholdsvis 15,1 måneder versus 12,7) med en 30 % reduktion i risikoen for død sammenlignet med mitoxantron (se tabel 3 og figur 1).
English: Renal disorders, have been reported in association with sepsis, severe dehydration due to diarrhoea, vomiting and obstructive uropathy.
Danish: Nyresygdomme er blevet rapporteret i forbindelse med sepsis, svær dehydrering på grund af diarré, opkastning og obstruktiv uropati.
English: MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Danish: A. FREMSTILLERE ANSVARLIGE FOR BATCHFRIGIVELSE
English: The incidence of grade ≥3 anaemia, increased AST, ALT, and bilirubin based on laboratory abnormalities were 10.5%, 0.7%, 0.9%, and 0.6%, respectively.
Danish: Forekomsten af grad ≥3 anæmi, forhøjet ASAT, ALAT og bilirubin baseret på laboratorieabnormiteter var henholdsvis 10,5 %, 0,7 %, 0,9 % og 0,6 %.
English: Among the 371 patients treated with cabazitaxel in the prostate cancer study, 240 patients were 65 years or over including 70 patients older than 75 years.
Danish: Blandt de 371 patienter, som blev behandlet med cabazitaxel i prostatacancerstudiet, var 240 patienter 65 år eller derover, inklusiv 70 patienter, som var ældre end 75 år.
English: Patients presenting end stage renal disease (creatinine clearance (CLCR< 15 mL/min/1.73 m2), by their condition and the limited amount of data available should be treated with caution and monitored carefully during treatment (see sections 4.4 and
Danish: Patienter med nyresygdom i terminalstadie (kreatinin clearance (CLCR)< 15 ml/min/1.73 m2) skal på baggrund af deres tilstand og de begrænsede tilgængelige data behandles med forsigtighed og monitoreres omhyggeligt under behandlingen (se pkt.
English: Data in patients below the 20 mg/m2 dose are limited.
Danish: Data for patienter, der får en dosis under 20 mg/m2, er begrænsede.
English: The incidence of grade ≥3 clinical neutropenia and febrile neutropenia adverse reactions were 21.3% and 7.5% respectively.
Danish: Forekomsten af grad ≥3 klinisk neutropeni og febril neutropeni var henholdsvis 21,3 % og 7,5 %.
English: Results of environmental risk assessment studies indicated that use of JEVTANA will not cause significant risk to the aquatic environment (see section 6.6 for disposal of unused product).
Danish: Resultater af miljøundersøgelser indikerede, at brugen af JEVTANA ikke vil udgøre nogen signifikant risiko for vandmiljøet (se pkt.
English: The benefit of resuming cabazitaxel treatment must be carefully evaluated.
Danish: Fordelen ved at genoptage behandling med cabazitaxel skal overvejes nøje.
English: If JEVTANA, at any step of its handling, should come into contact with the skin, wash immediately and thoroughly with soap and water.
Danish: Hvis JEVTANA på noget tidspunkt under håndteringen kommer i kontakt med huden, skal den straks vaskes grundigt med vand og sæbe.
English: Elderly people (≥65 years of age) may be more likely to experience certain adverse reactions including neutropenia and febrile neutropenia (see section 4.8).
Danish: Ældre personer (≥65 år) kan være mere tilbøjelige til at opleve bestemte bivirkninger, herunder neutropeni og febril neutropeni (se pkt.
English: No dose adjustment is necessary in patients with renal impairment, not requiring hemodialysis.
Danish: Dosisjustering er ikke nødvendig hos patienter med nedsat nyrefunktion, der ikke kræver hæmodialyse.
English: Step 2: Second (final) dilution for infusion
Danish: Trin 2: Anden (afsluttende) fortynding.
English: CAUTION: Two-step dilution required.
Danish: ADVARSEL: Kræver totrins-fortynding.
English: The phase 2 part did not demonstrate efficacy of cabazitaxel as single agent in paediatric population with recurrent or refractory diffuse intrinsic pontine glioma (DIPG) and high grade glioma (HGG) treated at 30 mg/m².
Danish: Fase 2-delen viste ikke effekt af cabazitaxel som enkeltstof i en pædiatrisk population med recidiverende eller refraktær diffust intrapontint gliom (DIPG) og højgrads-gliom (HGG) behandlet med 30 mg/m².
English: Adequate hydration should be ensured throughout treatment with cabazitaxel.
Danish: Der skal sørges for tilstrækkelig hydrering under hele behandlingen med cabazitaxel.
English: The concentrate is a clear yellow to brownish-yellow oily solution.
Danish: Koncentratet er en klar gul til brun-gul olieagtig opløsning.
English: 20 mg/m2.
Danish: 25 mg/m2 til 20 mg/m2.
English: Cabazitaxel is active in docetaxel-sensitive tumours.
Danish: Cabazitaxel er aktiv i docetaxel-følsomme tumorer.
English: Fatal ventricular fibrillation was reported in 1 patient (0.3%), and cardiac arrest in 2 patients (0.5%).
Danish: Dødelig ventrikelflimren blev rapporteret for en patient (0,3 %) og hjertestop for 2 patienter (0,5 %).
English: EXP Read the leaflet for the shelf life of the diluted solution.
Danish: EXP Læs indlægssedlen for oplysninger om holdbarheden af den fortyndede opløsning.
English: • stomach upsets including feeling sick (nausea), being sick (vomiting), diarrhoea or constipation
Danish: • mavebesvær, inklusive at føle sig syg (kvalme), opkastning, diarré eller forstoppelse
English: The other ingredients are polysorbate 80 and citric acid in the concentrate, and ethanol 96% and water for injections in the solvent (see section 2 “JEVTANA contains alcohol”).
Danish: Øvrige indholdsstoffer: polysorbat 80 og citronsyre i koncentratet samt ethanol 96 % og vand til injektionsvæsker i solvensen (se punkt 2 ”JEVTANA indeholder alkohol”).
English: The following two-step dilution process must be carried out in an aseptic manner for preparing the solution for infusion.
Danish: Følgende totrins-fortyndingsproces skal udføres på aseptisk vis med henblik på at klargøre infusionsvæsken.
English: In the population pharmacokinetic analysis in 70 patients of 65 years and older (57 from 65 to 75 and 13 patients above 75), no age effect on the pharmacokinetics of cabazitaxel was observed.
Danish: I den farmakokinetiske populationsanalyse af 70 patienter på 65 år og derover (57 i alderen 65-75 og 13 patienter over 75), blev der ikke observeret nogen aldersmæssig indvirkning på cabazitaxels farmakokinetik.
English: • you are allergic (hypersensitive) to cabazitaxel, to other taxanes, or polysorbate 80 or any of the other excipients of this medicine (listed in section 6),
Danish: • du er allergisk over for cabazitaxel, over for andre taxaner, over for polysorbat 80 eller et af de øvrige indholdsstoffer i dette lægemiddel (angivet i punkt 6),
English: The incidence of tachycardia on cabazitaxel was 1.6%, none of which were Grade ≥3.
Danish: Forekomsten af takykardi for cabaziataxel var 1,6 %, hvoraf ingen var grad ≥3.
English: Cabazitaxel is not recommended during pregnancy and in women of childbearing potential not using contraception.
Danish: Cabazitaxel anbefales ikke under graviditet og hos fødedygtige kvinder, som ikke bruger prævention.
English: Due to potential effects on male gametes and to potential exposure via seminal liquid, men treated with cabazitaxel should use effective contraception throughout treatment and are recommended to continue this for up to 6 months after the last dose of cabazitaxel.
Danish: På grund af den potentielle indvirkning på mandlige gameter og på potentiel eksponering via seminalvæske anbefales det, at mænd, som behandles med cabazitaxel, bruger effektiv prævention under hele behandlingen og fortsætter hermed i 6 måneder efter den sidste dosis cabazitaxel.
English: However a clinical study has shown that cabazitaxel (25 mg/m2 administered as a single 1-hour infusion) did not modify the plasma levels of midazolam, a probe substrate of CYP3A.
Danish: Et klinisk studie har imidlertid vist, at cabazitaxel (25 mg/m2 administreret som en enkelt 1-times infusion) ikke påvirkede plasmaniveauet af midazolam, et CYP3A-testsubstrat.
English: In vitro studies have shown that cabazitaxel is mainly metabolised through CYP3A (80% to 90%) (see section 5.2).
Danish: In vitro studier har vist, at cabazitaxel hovedsageligt metaboliseres via CYP3A (80-90 %) (se pkt.
English: Of the 595 patients treated with cabazitaxel 25 mg/m2 in the prostate cancer EFC 11785 study, 420 patients were 65 years or over.
Danish: Af de 595 patienter, som blev behandlet med cabazitaxel 25 mg/m2 i prostatacancer-studiet EFC 11785, var 420 patienter 65 år eller derover.
English: These medicines include the following: - ketoconazole, rifampicin (for infections); - carbamazepine, phenobarbital or phenytoin (for seizures); - St John's Wort (Hypericum perforatum) (herbal remedy for depression and other conditions); - statins (such as simvastatin, lovastatin, atorvastatin, rosuvastatin, or pravastatin) (for reducing the cholesterol in your blood); - valsartan (for hypertension); - repaglinide (for diabetes).
Danish: Disse lægemidler omfatter følgende: - ketoconazol, rifampicin (mod infektioner); - carbamazepin, phenobarbital eller phenytoin (mod krampeanfald); - perikon (Hypericum perforatum) (et naturlægemiddel mod depression og andre lidelser); - statiner (såsom simvastatin, lovastatin, atorvastatin, rosuvastatin eller pravastatin) (til at nedsætte kolesterol i blodet); - valsartan (mod forhøjet blodtryk);
English: Grade >2 peripheral neuropathy
Danish: Grad >2 perifer neuropati
English: • As part of your treatment, you will also take a corticosteroid medicine (prednisone or prednisolone) by mouth every day.
Danish: • I forbindelse med din behandling vil du også få kortikosteroid-medicin (prednison eller prednisolon) peroralt hver dag.
English: Cabazitaxel inhibited the transport of P-glycoprotein (PgP) (digoxin, vinblastin), Breast-Cancer-Resistant-Proteins (BCRP) (methotrexate) and Organic Anion Transporting Polypeptide OATP1B3 (CCK8) at concentrations at least 15 fold what is observed in clinical setting while it inhibited the transport of OATP1B1 (estradiol-17β-glucuronide) at concentrations only 5 fold what is observed in clinical setting.
Danish: Cabazitaxel hæmmede transporten af P-glykoprotein (PgP) (digoxin, vinblastin), Breast-Cancer-Resistance Proteiner (BCRP) (methotrexat) og organisk aniontransporterende polypeptid OATP1B3 (CCK8) ved koncentrationer, der var mindst 15 gange højere end under kliniske forhold, hvorimod det hæmmede transporten af OATP1B1 (estradiol-17βglukuronid) ved koncentrationer kun 5 gange højere end under kliniske forhold.
English: Concomitant administration of aprepitant, a moderate CYP3A inhibitor, had no effect on cabazitaxel clearance.
Danish: Samtidig administration af aprepitant, en moderat CYP3A-hæmmer, havde ingen effekt på cabazitaxel clearance.
English: Concentrate vial (60 mg - 1.5 ml)
Danish: Hætteglas med koncentrat (60 mg - 1,5 ml)
English: Cabazitaxel induced embryofoetal toxicity in female rats treated intravenously once daily from gestational days 6 through 17 linked with maternal toxicity and consisted of foetal deaths and decreased mean foetal weight associated with delay in skeletal ossification.
Danish: Cabazitaxel inducerede embryoføtal toksicitet i hunrotter, der blev behandlet intravenøst en gang dagligt fra 6. til og med 17. gestationsdag forbundet med maternel toksicitet, og bestod af føtale dødsfald og mindsket føtal middelvægt forbundet med forsinket skeletal ossifikation.
English: There is no known antidote to cabazitaxel.
Danish: Der er ikke nogen kendt antidot til cabazitaxel.
English: Exposures in animals were similar or lower than those seen in humans receiving clinically relevant doses of cabazitaxel.
Danish: Eksponering i dyr var tilsvarende eller lavere end dem, der ses hos mennesker, som modtager klinisk relevante doser af cabazitaxel.
English: JEVTANA is used to treat prostate cancer that has progressed after having had other chemotherapy.
Danish: JEVTANA bruges til at behandle prostatacancer, der har udviklet sig efter anden kemoterapibehandling.
English: Anaemia has been observed in patients receiving cabazitaxel (see section 4.8).
Danish: Anæmi er observeret hos patienter, der behandles med cabazitaxel (se pkt 4.8).
English: Unopened vials 3 years.
Danish: Uåbnede hætteglas 3 år
English: Cardiac failure events were more common on cabazitaxel, the event term being reported for 2 patients (0.5%).
Danish: Tilfælde med hjertesvigt var mere almindelige for cabazitaxel, denne hændelse blev rapporteret hos 2 patienter (0,5 %).
English: Cabazitaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells.
Danish: Cabazitaxel er et antineoplastisk middel, der virker ved at forstyrre det mikrotubulære netværk i cellerne.
English: Cases of interstitial pneumonia/pneumonitis and interstitial lung disease, sometimes fatal have been reported with an unknown frequency (cannot be estimated from the available data) (see section 4.4).
Danish: Der er rapporteret om tilfælde af interstitiel pneumoni/pneumonitis og interstitiel lungesygdom, i nogle tilfælde med dødeligt udfald med ukendt frekvens (kan ikke estimeres ud fra forhåndenværende data) (se pkt.
English: Cabazitaxel is eliminated primarily via liver metabolism.
Danish: Cabazitaxel elimineres primært via levermetabolisme.
English: A population pharmacokinetic analysis was carried out in 170 patients including patients with advanced solid tumours (n=69), metastatic breast cancer (n=34) and metastatic prostate cancer (n=67).
Danish: En farmakokinetisk populationsanalyse blev udført på 170 patienter, inklusiv patienter med avancerede faste tumorer (n=69), metastatisk brystkræft (n=34) og metastatisk prostatacancer (n=67).
English: Available pharmacokinetics data in animals have shown excretion of cabazitaxel and its metabolites in milk (see section 5.3).
Danish: Foreliggende farmakokinetiske data hos dyr har vist udskillelse af cabazitaxel og dets metabolitter i mælk (se pkt.
English: In a non-inferiority, multicenter, multinational, randomized, open label phase III study (EFC11785 study), 1200 patients with metastatic castration resistant prostate cancer, previously treated with a docetaxel-containing regimen, were randomized to receive either cabazitaxel 25 mg/m2 (n=602) or 20 mg/m2 (n=598) dose.
Danish: I et noninferioritet, multinationalt, randomiseret, åbent fase III-multicenterstudie (EFC11785-studiet), blev 1.200 patienter med metastatisk kastrationsresistent prostatacancer, der tidligere var behandlet med et docetaxel-indeholdende regime, randomiseret til at få cabazitaxel i en dosis på enten 25 mg/m2 (n = 602) eller 20 mg/m2 (n = 598).
English: The volume of distribution (Vss) was 4870 l (2640 l/m² for a patient with a median BSA of 1.84 m²) at steady state.
Danish: Distribution Distributionsvolumenet (Vss) var 4870 l (2640 l/m² for en patient med en median BSA på 1,84 m²)
English: From 20 to 15 mg/m2: 58 (10.0%) From 15 to 12 mg/m2: 9 (1.6%)
Danish: Fra 20 til 15 mg/m2: 58 (10,0%) Fra 15 til 12 mg/m2: 9 (1,6%)
English: Cabazitaxel is extensively metabolised in the liver (>95%), mainly by the CYP3A isoenzyme (80% to 90%).
Danish: Cabazitaxel metaboliseres ekstensivt i leveren (> 95 %), hovedsageligt af CYP3A-isoenzymet (8090 %).
English: This medicine must not be mixed with other medicines except those used for the dilutions.
Danish: Denne medicin må ikke blandes med anden medicin ud over dem, som anvendes til fortynding.