FrancophonIA/ELRC3.0 huggingface dataset:
English: In the case of signs suggestive of an adrenal insufficiency, in addition to the general measures to eliminate the medicinal product and reduce its absorption, a 100 mg dose of hydrocortisone should be administered at once, together with saline and glucose infusions.
Croatian: Ako simptomi ukazuju na adrenalnu insuficijenciju, osim općih mjera uklanjanja lijeka i smanjenja njegove apsorpcije, odmah treba primijeniti 100 mg hidrokortizona zajedno s infuzijom fiziološke otopine i glukoze.
English: The most serious adverse reaction is hepatotoxicity, primarily as acute hepatocellular toxicity, but may also result in cholestatic injury or a mixed pattern of toxicity.
Croatian: Najozbiljnija nuspojava je hepatotoksičnost, prvenstveno u obliku hepatocelularne toksičnosti, no može doći i do kolestatskog ili mješovitog oštećenja jetre.
English: Lurasidone:
Croatian: Lurasidon:
English: Your doctor will test your blood before you start the treatment and regularly during the treatment to detect any possible abnormalities and also to measure the levels of cortisol.
Croatian: Liječnik će Vam prije početka liječenja i redovito tijekom liječenja napraviti pretragu krvi kako bi otkrio moguće abnormalnosti te kako bi izmjerio razine kortizola.
English: Electrophysiological studies have shown that ketoconazole inhibits the rapidly activating component of the cardiac delayed rectifier potassium current, prolongs the action potential duration, and may prolong the QT interval.
Croatian: Elektrofiziološka ispitivanja su pokazala da ketokonazol inhibira brzo aktivirajuću komponentu odgođene ispravljačke kalijeve struje u srcu, da produljuje trajanje akcijskog potencijala te da može produljiti QT interval.
English: Ketoconazole daily dose should be periodically adjusted on an individual basis with the aim to normalise urinary free cortisol and/or plasma cortisol levels.
Croatian: Dnevnu dozu ketokonazola treba povremeno prilagođavati individualnim potrebama bolesnika radi normalizacije slobodnog kortizola u urinu i/ili razina kortizola u plazmi.
English: Therefore, do not stop taking Ketoconazole HRA unless your doctor tells you.
Croatian: Stoga ne prekidajte liječenje Ketoconazoleom HRA osim ako tako ne odredi Vaš liječnik.
English: Sunitinib Dasatinib Lapatinib Nilotinib Erlotinib Dabrafenib Cabozantinib
Croatian: Nilotinib Erlotinib Dabrafenib Kabozantinib
English: Concomitant therapy with medicinal products that are contraindicated during treatment with ketoconazole and resulting in potentially life-threatening adverse reactions :
Croatian: Istovremeno liječenje nekim od sljedećih lijekova koji su kontraindicirani tijekom liječenja ketokonazolom i mogu dovesti do nuspojava potencijalno opasnih po život:
English: Due to the known hepatotoxicity of ketoconazole, the treatment must not be initiated in patients with liver enzymes levels above 2 times the upper limit of normal (see section 4.3).
Croatian: Zbog poznate hepatotoksičnosti ketokonazola liječenje se ne smije započeti u bolesnika čije su razine jetrenih enzima dvostruko veće od gornje granice normalnih vrijednosti (vidjeti dio 4.3).
English: Allergic conditions including anaphylactic shock, anaphylactoid reaction and anaphylactic reaction and angioedema
Croatian: Alergijska stanja uključujući anafilaktički šok, anafilaktoidne reakcije i anafilaktičke reakcije i angioedem
English: Studies in pregnant rats and in guinea pigs with 3H-ketoconazole indicate that ketoconazole crosses the placenta.
Croatian: Ispitivanja provedena na skotnim štakorima i zamorcima s 3H-ketokonazolom pokazuju da ketokonazol prolazi kroz placentu.
English: - Ketoconazole can inhibit the transport of medicinal products by P-gp, which may result in an increased plasma concentration of these medicinal products.
Croatian: - Ketokonazol može inhibirati prijenos lijekova pomoću P-glikoproteina, što može dovesti do povećane koncentracije tih lijekova u plazmi.
English: Ketoconazole HRA is indicated for the treatment of endogenous Cushing's syndrome in adults and adolescents above the age of 12 years.
Croatian: Ketoconazole HRA indiciran je za liječenje endogenog Cushingovog sindroma u odraslih i adolescenata starijih od 12 godina.
English: Liver problems can rarely happen (may affect up to 1 in 1,000 people).
Croatian: Rijetko može doći do problema s jetrom (mogu se javiti u manje od 1 na 1000 osoba).
English: Immunosuppressants Everolimus Sirolimus (rapamycin)
Croatian: Everolimus Sirolimus (rapamicin)
English: • Myalgia (muscle pain)
Croatian: • mialgija (bol u mišićima)
English: Data from 91 patients with the ectopic ACTH syndrome treated with ketoconazole were reviewed, along with 18 individual case reports.
Croatian: Analizirani su podaci od 91 bolesnika s ektopičnim ACTH sindromom liječenih ketokonazolom, te 18 pojedinačnih prikaza slučajeva.
English: Stop taking Ketoconazole HRA and tell your doctor straight away if you experience any of the following: - long-lasting severe headache or blurred vision - severe lack of appetite (anorexia) - weight loss - nausea or vomiting - unusual tiredness or fever - stomach pain - muscle weakness - yellowing of the skin or whites of the eyes - unusually dark urine or pale stools
Croatian: Prestanite uzimati Ketoconazole HRA i odmah obavijestite liječnika ako osjetite neki od sljedećih simptoma: - dugotrajna jaka glavobolja ili zamućen vid - izražen gubitak apetita (anoreksija) - gubitak težine - mučnina ili povraćanje - neobičan umor ili vrućica - bol u trbuhu - slabost mišića - žuta boja kože ili žute bjeloočnice - neobično tamna mokraća ili blijeda stolica
English: Mean peak plasma concentrations of approximately 3.5 μg/ml are reached within 1 to 2 hours, following oral administration of a single 200 mg dose taken with a meal.
Croatian: Srednje vršne koncentracije u plazmi od približno 3,5 μg/ml postižu se unutar 1 do 2 sata nakon peroralne primjene pojedinačne doze od 200 mg uzete s obrokom.
English: Dosing regimens for maintenance therapy Subsequent maintenance therapy can be administered in one of two ways: - Block-only regimen: the maintenance dose of ketoconazole may be continued as described above; - Block-and-replace regimen: the maintenance dose of ketoconazole should be further increased by 200 mg and concomitant corticosteroid replacement therapy should be added (see section 4.4).
Croatian: Naknadna terapija održavanja može se davati na jedan od sljedeća dva načina: - Režim liječenja samo blokadom: doza održavanja ketokonazola može se nastaviti kako je gore opisano; - Režim liječenja blokadom i nadomještanjem: doza održavanja ketokonazola mora se povećati za još 200 mg i dodati istovremena nadomjesna terapija kortikosteroidima (vidjeti dio 4.4).
English: The toxicological profile of ketoconazole has been established from long term studies in rats and dogs.
Croatian: Toksikološki profil ketokonazola utvrđen je na temelju dugotrajnih ispitivanja na štakorima i psima.
English: If you have taken more than the prescribed dose of Ketoconazole HRA, you must contact your doctor immediately.
Croatian: Ako ste uzeli više Ketoconazolea HRA od propisane doze, odmah se javite svom liječniku.
English: Exceptional cases of a disulfiram-like reaction have been reported when ketoconazole was co-administered with alcohol, characterised by flushing, rash, peripheral oedema, nausea and headache, have been reported.
Croatian: Prijavljeni su iznimni slučajevi reakcije na alkohol slične disulfiramu kada je ketokonazol primjenjivan istovremeno s alkoholom, a karakteriziraju je navale crvenila, osip, periferni edem, mučnina i glavobolja.
English: In most of the publications the maintenance dose varied between 600 mg/day and 800 mg/day; - When the effective dose of ketoconazole is established, monitoring of urinary free cortisol and/or plasma cortisol levels may be performed every 3 to 6 months (see section 4.4); - In the case of adrenal insufficiency and depending on the severity of the event, the dose of ketoconazole should be decreased by at least 200 mg/day or the treatment should be temporarily discontinued and/or a corticosteroid therapy should be added until the resolution of the event.
Croatian: U većini publikacija, doza održavanja varira od 600 mg/dan do 800 mg/dan; - Nakon što se utvrdi učinkovita doza ketokonazola, treba svakih 3 do 6 mjeseci pratiti razine slobodnog kortizola u urinu i/ili razine kortizola u plazmi (vidjeti dio 4.4); - U slučaju insuficijencije nadbubrežne žlijezde te ovisno o težini događaja, dozu ketokonazola treba smanjiti za najmanje 200 mg/dan ili liječenje treba privremeno prekinuti i/ili treba dodatno uvesti kortikosteroidnu terapiju dok se događaj ne riješi.
English: Józefów 9, 99-300 Kutno Poland
Croatian: Polfarmex S.A. ul. Józefów 9, 99-300 Kutno Poljska
English: Ketoconazole was not genotoxic in vitro and in vivo.
Croatian: Ketokonazol nije pokazao genotoksičnost in vitro ni in vivo.
English: Data from 17 patients with adrenal tumours and from 2 patients with primary nodular adrenocortical hyperplasia (NAH) treated with ketoconazole are available in the literature along with 17 individual case reports of patients with benign or malignant tumours or NAH and 2 paediatric cases of McCune Albright syndrome.
Croatian: U literaturi su dostupni podaci za 17 bolesnika s tumorom nadbubrežne žlijezde i 2 bolesnika s primarnom nodularnom adrenokortikalnom hiperplazijom (NAH) liječenih ketokonazolom te 17 pojedinačnih prikaza slučajeva za bolesnike s benignim ili malignim tumorom ili NAH-om kao i podaci o 2 pedijatrijska slučaja McCune-Albrightovog sindroma.
English: There are some medicines that must not be taken with Ketoconazole HRA (see section 2).
Croatian: Neki lijekovi ne smiju se uzimati s Ketoconazoleom HRA (pogledajte dio 2).
English: Irinotecan:
Croatian: Irinotekan:
English: AUC: ↓0.28-fold
Croatian: AUC: ↓ 0,28 puta
English: If you take more Ketoconazole HRA than you should
Croatian: Ako uzmete više Ketoconazolea HRA nego što ste trebali
English: Anti-infectives Rifabutin Rifampicin Isoniazid
Croatian: Rifabutin Rifampicin Izoniazid
English: Dose adjustment of dihydropyridines and verapamil may be required.
Croatian: Može biti potrebna prilagodba doze dihidropiridina i verapamila.
English: Before starting the treatment, it is mandatory: - to measure liver enzymes (ASAT, ALAT, gammaGT and alkaline phosphatase) and bilirubin - to inform the patients about the risk of hepatotoxicity, including to stop the treatment and to contact their doctor immediately if they feel unwell or in the event of symptoms such as anorexia, nausea, vomiting, fatigue, jaundice, abdominal pain or dark urine.
Croatian: Prije početka liječenja obavezno treba: - izmjeriti enzime jetre (AST, ALT, GGT i alkalnu fosfatazu) i razine bilirubina - obavijestiti bolesnike o riziku od hepatotoksičnosti, uključujući da prekinu terapiju i odmah obavijeste liječnika ako se osjećaju loše ili u slučaju pojave simptoma kao što su anoreksija, mučnina, povraćanje, umor, žutica, bol u abdomenu ili taman urin.
English: Adrenal function should be monitored at regular intervals since adrenal insuficiency can occur during the treatment under conditions of a relative cortisol deficiency due to an increased glucocorticoid demand (e.g. in case of stress, surgery, or infection); and/or in case of ketoconazole overtreatment (for the patients treated with a block-only regimen); or if there is insufficient glucocorticoid replacement therapy (for the patients treated with a block-and-replace regimen).
Croatian: Adrenalnu funkciju treba redovito pratiti budući da tijekom liječenja može doći do adrenalne insuficijencije u uvjetima relativne deficijencije kortizola zbog povećane potrebe za glukokortikoidima (npr. u slučaju stresa, operacije ili infekcije); i/ili u slučaju prekomjerne terapije ketokonazolom (u bolesnika liječenih režimom liječenja samo blokadom); ili ako je nadomjesno liječenje glukokortikoidima nedovoljno (u bolesnika liječenih režimom liječenja blokadom i nadomještanjem).
English: Your adrenal function will be monitored at regular intervals as this is the standard care in the follow-up of Cushing's syndrome therapy and since adrenal insuficiency can occur during the treatment.
Croatian: Funkcija Vaše nadbubrežne žlijezde redovito će se pratiti budući da je to dio standardne skrbi u praćenju tijekom liječenja Cushingovog sindroma i budući da tijekom liječenja može doći do zatajivanja nadbubrežne žlijezde.
English: Paritaprevir/Ombitasvir (ritonavir)
Croatian: Paritaprevir/ombitasvir
English: Dyspepsia, flatulence, tongue discoloration, dry mouth, dysgeusia
Croatian: Dispepsija, flatulencija, promjena boje jezika, suhoća usta, disgeuzija
English: Hepatic impairment Ketoconazole is contraindicated in patients with acute or chronic hepatic impairment (see sections 4.3, 4.4 and
Croatian: Ketokonazol je kontraindiciran u bolesnika s akutnim ili kroničnim oštećenjem jetre (vidjeti dijelove 4.3, 4.4 i 5.3).
English: The pharmacokinetics of ketoconazole were not significantly different in patients with renal failure compared to healthy subjects.
Croatian: Farmakokinetika ketokonazola nije se značajno razlikovala u bolesnika s oštećenjem bubrega u odnosu na zdrave ispitanike.
English: A dose reduction of ketoconazole should be considered when coadministered with ritonavir dosed as an antiretroviral medicinal product or as a pharmacokinetic enhancer.
Croatian: Treba razmotriti smanjenje doze ketokonazola kada se primjenjuje istovremeno s ritonavirom u dozi antiretrovirusnog lijeka ili farmakokinetičkog pojačivača.
English: Monitoring of adrenal function
Croatian: Praćenje adrenalne funkcije
English: In vitro studies have shown that CYP3A4 is the major enzyme involved in the metabolism of ketoconazole.
Croatian: In vitro ispitivanja pokazala su da je CYP3A4 glavni enzim uključen u metabolizam ketokonazola.
English: You should know that your liver enzyme tests will be regularly monitored before starting the treatment, once weekly during the first month after Ketoconazole HRA initiation and then monthly for 6 months due to the risk of serious hepatic toxicity.
Croatian: Vaše razine jetrenih enzima prije početka liječenja, jednom tjedno u prvih mjesec dana liječenja Ketoconazoleom HRA, a potom jednom mjesečno tijekom 6 mjeseci zbog rizika od ozbiljne toksičnosti za jetru.
English: - This medicine does not require any special storage conditions - Do not throw away any medicines via wastewater or household waste.
Croatian: Nikada nemojte nikakve lijekove bacati u otpadne vode ili kućni otpad.
English: Patients with Cushing's syndrome and coexisting inflammatory/autoimmune disorders should be supervised after normalisation of cortisol levels on ketoconazole.
Croatian: Bolesnike s Cushingovim sindromom i koegzistirajućim upalnim/autoimunim poremećajima liječene ketokonazolom potrebno je pratiti nakon normalizacije razine kortizola.
English: Overall, ketoconazole was shown to be an effective medicinal product for normalising cortisol levels in all causes of Cushing's syndrome and, if tolerated, ketoconazole treatment can be maintained for a long period.
Croatian: Općenito, ketokonazol se pokazao učinkovitim lijekom u normalizaciji razina kortizola kod Cushingovog sindroma, neovisno o njegovu uzroku, a ako se podnosi, liječenje ketokonazolom može biti dugotrajno.
English: Not recommended due to the increased risk of adverse reactions.
Croatian: Ne preporučuje se zbog povećanog rizika od štetnih događaja.
English: Jozefow 9 99-300 Kutno Poland
Croatian: Polfarmex S.A. ul. Jozefow 9 99-300 Kutno Poljska
English: The list above is not an inclusive list of compounds that may interact with ketoconazole and result in potentially life-threatening reactions.
Croatian: Ovaj popis nije sveobuhvatan popis tvari koje mogu uzrokovati interakcije s ketokonazolom i izazvati nuspojave potencijalno opasne po život.
English: - In vitro data indicate that ketoconazole is an inhibitor of CYP1A2 and does not significantly inhibit CYP 2A6 and 2E1.
Croatian: - In vitro podaci pokazuju da je ketokonazol inhibitor CYP1A2 te da ne inhibira CYP2A6 i 2E1 u značajnoj mjeri.
English: Headache, dizziness, somnolence
Croatian: Glavobolja, omaglica, somnolencija
English: Potent inhibitors of CYP3A4 (e.g. antivirals such as ritonavir, ritonavir-boosted darunavir and ritonavirboosted fosamprenavir) may increase the bioavailability of ketoconazole, these medicinal products should be used with caution when co-administered with ketoconazole and patients should be monitored closely for signs and symptoms of adrenal insuficiency.
Croatian: Budući da snažni inhibitori CYP3A4 (npr. antivirusni lijekovi poput ritonavira, darunavira pojačanog ritonavirom i fosamprenavira pojačanog ritonavirom) mogu povećati bioraspoloživost ketokonazola, ti se lijekovi trebaju upotrebljavati oprezno kada se primjenjuju istovremeno s ketokonazolom, a bolesnike treba pomno pratiti radi uočavanja znakova i simptoma adrenalne insuficijencije.
English: What Ketoconazole HRA is and what it is used for
Croatian: Što je Ketoconazole HRA i za što se koristi
English: Adrenal insufficiency may occur in patients on ketoconazole without corticosteroid substitution (block-only regimen) or if there is an insufficient glucocorticoid replacement therapy (for the patients treated with a blockand-replace regimen).
Croatian: Može doći do adrenalne insuficijencije u bolesnika liječenih ketokonazolom bez nadomjesne terapije kortikosteroidima (režim liječenja samo blokadom) ili u slučaju nedostatne nadomjesne terapije glukokortikoidima (u bolesnika liječenih režimom blokade i nadomještanja).
English: Hepatic enzyme increased
Croatian: Povišeni enzimi jetre
English: colchicine: medicine to treat gout fesoterodine and solifenacin: medicines to treat the symptoms of an overactive bladder telithromycin and clarithromycin: medicine used to treat infections
Croatian: kolhicin: lijek za liječenje gihta fezoterodin i solifenacin: lijekovi za liječenje simptoma preaktivnog mokraćnog mjehura telitromicin i klaritromicin: lijekovi za liječenje infekcija
English: Endocrine disorders Common
Croatian: Endokrini poremećaji
English: • Gynaecomastia (enlargement in breast tissues in male)
Croatian: • ginekomastija (povećanje tkiva dojke u muškaraca)
English: Medicines that can interact with Ketoconazole HRA include: - pasireotide, another drug used to treat a subset of the Cushing's syndrome because it can lead to severe side effects in patients suffering from cardiac disorders - medicines taken by mouth that prevent blood clots from forming: rivaroxaban, apixaban, edoxaban,
Croatian: Lijekovi koji mogu uzrokovati interakcije s Ketoconazoleom HRA: - pasireotid, još jedan lijek kojim se liječi podvrsta Cushingova sindroma jer može uzrokovati teške nuspojave u bolesnika sa srčanim poremećajima - lijekovi koji se uzimaju kroz usta koji sprečavaju nastajanje krvnih ugrušaka: rivaroksaban, apiksaban,
English: Improvement of clinical symptoms was noted in most patients after initiation of treatment.
Croatian: Nakon početka liječenja u većine je bolesnika došlo do poboljšanja kliničkih simptoma.
English: ranolazine
Croatian: Ranolazin
English: Fesoterodine and solifenacin are contraindicated in patients with renal impairment (see section 4.3).
Croatian: Fezoterodin i solifenacin kontraindicirani su u bolesnika s oštećenjem bubrega (vidjeti dio 4.3).
English: Therefore, ketoconazole is an inhibitor of cortisol and aldosterone synthesis.
Croatian: Stoga je ketokonazol inhibitor sinteze kortizola i aldosterona.
English: Post Authorisation safety study (PASS): Multi-country, observational registry to collect clinical information on patients with Cushing Syndrome patients exposed with Ketoconazole (preferably using the existing European Registry on Cushing's syndrome (ERCUSYN) registry where feasible ), to assess drug utilization patterns and to document the safety (eg hepatotoxicity, QT prolongation) and effectiveness of ketoconazole
Croatian: Ispitivanje sigurnosti primjene lijeka nakon davanja odobrenja za stavljanje lijeka u promet (PASS): Uspostavljanje opservacijskog registra u više država za prikupljanje kliničkih informacija o bolesnicima s Cushingovim sindromom koji uzimaju ketokonazol (po mogućnosti uz korištenje postojećeg Europskog registra bolesnika s Cushingovim sindromom (ERCUSYN)) radi utvrđivanja obrazaca uzimanja lijeka i dokumentiranja sigurnosti (npr. hepatotoksičnost, produljenje QT intervala) i učinkovitosti ketokonazola
English: Effects of ketoconazole on the metabolism of the other medicinal products
Croatian: Učinci ketokonazola na metabolizam drugih lijekova
English: Ketoconazole:
Croatian: Ketokonazol:
English: Ketoconazole is an imidazole derivative that is a potent inhibitor of cortisol synthesis resulting from its ability to inhibit several cytochrome P450 enzymes in the adrenal glands.
Croatian: Ketokonazol je derivat imidazola koji je snažan inhibitor sinteze kortizola zahvaljujući svojoj sposobnosti inhibicije nekoliko enzima citokroma P450 u nadbubrežnim žlijezdama.
English: Control of cortisol levels, either in serum/plasma or urine, was used to assess the efficacy of the treatment, along with the evaluation of clinical symptoms of Cushing's syndrome.
Croatian: Djelotvornost liječenja ocjenjivana je na temelju kontrole razine kortizola u serumu/plazmi ili urinu i evaluacije kliničkih simptoma Cushingovog sindroma.
English: Photosensitivity, erythema multiforme, dermatitis, erythema, , xeroderma
Croatian: Fotoosjetljivost, multiformni eritem, dermatitis, eritem, kseroderma
English: It may be necessary to lower the dose of alfentanil and fentanyl.
Croatian: Možda će trebati smanjiti dozu alfentanila i fentanila.
English: Coadministration of potent enzyme inducers of CYP3A4 may decrease the bioavailibity of ketoconazole.
Croatian: Istovremena primjena snažnih enzimskih induktora CYP3A4 može smanjiti bioraspoloživost ketokonazola.
English: Medicinal products affecting the absorption of ketoconazole
Croatian: Lijekovi koji utječu na apsorpciju ketokonazola
English: CYP3A4-metabolised and/or P-gp substrates known to prolong the QT interval may be contraindicated or not recommended depending on the observed or expected effect with ketoconazole (i.e. resulting in augmentation of the plasma concentration, AUC, Cmax of the drugs) and the known therapeutic margins of the drugs.
Croatian: Primjena supstrata koji se metaboliziraju posredstvom CYP3A4 i/ili supstrata P-glikoproteina, koji produljuju QT interval može biti kontraindicirana ili nepreporučljiva ovisno o zabilježenom ili očekivanom učinku s ketokonazolom (tj. što rezultira povećanjem koncentracija u plazmi, AUC, Cmax lijekova) i poznatim terapijskim širinama lijekova.
English: Ketoconazole at doses of 40 mg/kg/day and higher produces evidence of embryotoxicity and teratogenicity in rats and rabbits.
Croatian: Pri dozama od 40 mg/kg/dan i više ketokonazol pokazuje znakove embriotoksičnosti i teratogenosti u štakora i kunića.
English: No change in plasma concentration were shown with paclitaxel concentrate.
Croatian: Paklitaksel: Nisu uočene promjene u plazmatskoj koncentraciji pri primjeni koncentrata paklitaksela.
English: In case of adrenal insufficiency, Ketoconazole HRA treatment should be temporarily discontinued or the dose reduced and, if needed, a corticosteroid substitution therapy added.
Croatian: U slučaju adrenalne insuficijencije privremeno treba prekinuti liječenje Ketoconazoleom HRA ili smanjiti dozu, a ako je potrebno, treba dodatno uvesti nadomjesnu kortikosteroidnu terapiju.
English: The most frequent adverse reactions are adrenal insufficiency, nausea, vomiting, abdominal pain, diarrhoea, pruritus, rash and the hepatic enzymes increased.
Croatian: Najčešće nuspojave uključuju adrenalnu insuficijenciju, mučninu, povraćanje, bol u abdomenu, proljev, pruritus, osip i povišenje jetrenih enzima.
English: Reboxetine: AUC: ↑ 1.5-fold of both enantiomers
Croatian: Reboksetin: AUC: ↑ 1,5 puta za oba enantiomera
English: The oxycodone dose may be adjusted.
Croatian: Doza oksikodona se može prilagoditi.
English: The treatment must not be initiated in patients with liver enzymes levels above 2 times the upper limit of normal
Croatian: Liječenje ne smiju započinjati bolesnici čiji su jetreni enzimi dvostruko viši od gornje granice normalnih vrijednosti.