FrancophonIA/ELRC3.0 huggingface dataset:
English: Opicapone may interfere with the metabolism of medicinal products containing a catechol group that are metabolised by COMT, e.g. rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dopexamine or dobutamine, leading to potentiated effects of these medicinal products.
Danish: Opicapon kan interferere med metaboliseringen af lægemidler, der indeholder en catechol-gruppe, der metaboliseres af COMT, f.eks. rimiterol, isoprenalin, adrenalin, noradrenalin, dopamin, dopexamin eller dobutamin, hvilket medfører forstærket virkning af disse lægemidler.
English: If one dose is missed, the next dose should be taken as scheduled.
Danish: Hvis en dosis glemmes, skal den næste dosis tages på det planlagte tidspunkt.
English: Effect of transporters on opicapone
Danish: Transportørers effekt på opicapon
English: In rats, opicapone did not affect male and female fertility or prenatal development at exposure levels 22 times the therapeutic exposure in humans.
Danish: Hos rotter påvirkede opicapon ikke fertiliteten hos han- og hundyr eller den prænatale udvikling ved eksponeringsniveauer, der var 22 gange den terapeutiske eksponering hos mennesker.
English: Take the medicine package and this leaflet with you.
Danish: Medbring medicinpakken og denne indlægsseddel.
English: Effect of opicapone on transporters
Danish: Opicapons effekt på transportører
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER OPA/Al/PVC//Al
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP BLISTER OPA/Al/PVC//Al
English: Patients and care-givers should be made aware that impulse control disorders including pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists and/or other dopaminergic treatments.
Danish: Patienter og omsorgspersoner skal gøres opmærksomme på, at manglende impulskontrol, herunder patologisk spilletrang/ludomani, øget libido, hyperseksualitet, overdrevent forbrug eller overdrevne indkøb samt overspisning eller tvangsspisning kan forekomme hos patienter i behandling med dopaminagonister og/eller andre dopaminerge lægemidler.
English: These behaviours are called ‘impulse control disorders' and can include: addictive gambling, an abnormally high sex drive or an increased preoccupation with sexual thoughts or feelings.
Danish: Denne adfærd kaldes manglende impulskontrol og kan omfatte øget spilletrang/ludomani, hyperseksualitet eller en øget optagethed af seksuelle tanker eller følelser.
English: Anxiety, Depression, Hallucination auditory, Nightmare, Sleep disorder.,
Danish: Angst, depression, auditive hallucinationer, mareridt, søvnforstyrrelser
English: However, clinical interaction studies conducted with warfarin showed no effect of opicapone on the pharmacodynamics of warfarin, a substrate of CYP2C9.
Danish: Kliniske interaktionsstudier udført med warfarin viste midlertid ingen effekt af opicapon på farmakodynamikken for warfarin, et CYP2C9-substrat.
English: At steady state, opicapone 50 mg significantly increased the extent of levodopa systemic exposure approximately 2 fold compared to placebo following a single oral administration of either 100/25 mg levodopa/carbidopa or 100/25 mg levodopa/benserazide administered 12 h after the opicapone dose.
Danish: Ved steady state øgede opicapon 50 mg signifikant den systemiske eksponering af levodopa, ca. 2 gange i forhold til placebo efter en enkel oral administration af enten 100/25 mg levodopa/carbidopa eller 100/25 mg levodopa/benserazid administreret 12 timer efter opicapon-dosen.
English: Increases in liver enzymes were reported in studies with nitrocatechol inhibitors of catechol-Omethyltransferase (COMT).
Danish: Der er blevet rapporteret stigning i leverenzymer i studier med nitrocatechol-hæmmere af catechol-O-methyltransferase (COMT).
English: Ongentys is indicated as adjunctive therapy to preparations of levodopa/ DOPA decarboxylase inhibitors (DDCI) in adult patients with Parkinson's disease and end-of-dose motor fluctuations who cannot be stabilised on those combinations.
Danish: Ongentys er indiceret som supplement til præparater med levodopa/DOPA-decarboxylasehæmmer (DDCI) til voksne patienter med Parkinsons sygdom og med motoriske fluktuationer ved aftagende medicinniveau (end-of-dose), som ikke kan stabiliseres på disse kombinationer.
English: Behaviours such as these have been reported in patients using other medicines for Parkinsons´s disease.
Danish: Disse adfærdsmønstre er blevet rapporteret hos patienter, som bruger anden medicin til behandling af Parkinsons sygdom.
English: The LS mean reduction in absolute OFF-time from baseline to endpoint in the entacapone group was -78.7 minutes.
Danish: Den gennemsnitlige reduktion, beregnet ved mindste kvadraters metode (LS), i absolut OFF-tid fra baseline til endepunkt i entacapon-gruppen var -78,7 minutter.
English: If you stop taking Ongentys your doctor may need to adjust the dose of other medicines that you are taking to treat Parkinson's disease.
Danish: Hvis du stopper med at tage Ongentys, er det muligt, at din læge skal justere dosen af anden medicin, som du tager til behandling af Parkinsons sygdom.
English: Sulphation of opicapone appears to be the major metabolic pathway in humans, yielding the inactive opicapone sulphate metabolite.
Danish: Sulfatering af opicapon virker til at være den primære metaboliseringsvej hos mennesker, hvorved den inaktive opicapon-sulfatmetabolit dannes.
English: The efficacy and safety of opicapone has been demonstrated in two Phase 3 double-blind, placebo and active (Study 1 only) controlled studies in 1,027 randomized adult patients with Parkinson's disease treated with levodopa/DDCI (alone or in combination with other antiparkinsonian drugs) and end-ofdose motor fluctuations for up to 15 weeks.
Danish: Opicapons virkning og sikkerhed er blevet påvist i to dobbeltblinde fase 3-studier med placebo- og aktiv (kun i studie 1) kontrol med 1.027 randomiserede voksne patienter med Parkinsons sygdom, behandlet med levodopa/DDCI (alene eller i kombination med andre antiparkinsonmidler) og motoriske end-of-dose fluktuationer i op til 15 uger.
English: Opicapone is a peripheral, selective and reversible catechol-O-methyltransferase (COMT) inhibitor endowed with a high binding affinity (sub-picomolar) that translates into a slow complex dissociation rate constant and a long duration of action (>24 hours) in vivo.
Danish: Opicapon er en perifer, selektiv og reversibel catechol-O-methyltransferase-hæmmer (COMT-hæmmer) med høj bindingsaffinitet (sub-picomolær), som kommer til udtryk i en langsom, kompleks dissociationshastighedskonstant og en lang virkningsvarighed (> 24 timer) in vivo.
English: Lactose monohydrate Sodium starch glycolate, Type A Maize starch, pregelatinized Magnesium stearate
Danish: Lactosemonohydrat Natriumstivelsesglykolat, type A Majsstivelse, pregelatineret Magnesiumstearat
English: The dose of other medicines to treat Parkinson's disease may need to be adjusted when you start taking Ongentys.
Danish: Det kan være nødvendigt at justere dosen af anden medicin til behandling af Parkinsons sygdom, når du begynder at tage Ongentys.
English: Contents of the pack and other information What Ongentys contains
Danish: Pakningsstørrelser og yderligere oplysninger Ongentys indeholder:
English: Concomitant use of opicapone and MAO inhibitors for the treatment of Parkinson's disease, e.g. rasagiline (up to 1 mg/day) and selegiline (up to 10 mg/day in oral formulation or 1.25 mg/day in buccal absorption formulation), is permissible (see section 4.3).
Danish: Samtidig brug af opicapon og MAO-hæmmere til behandling af Parkinsons sygdom, f.eks. rasagilin (op til 1 mg/dag) og selegilin (op til 10 mg/dag i orale formuleringer eller 1,25 mg/dag i bukkale formuleringer) er acceptabelt (se pkt.
English: Therefore, it can be presumed that opicapone and its metabolites are mainly excreted in the faeces.
Danish: Det kan derfor antages, at opicapon og dets metabolitter hovedsageligt udskilles i fæces.
English: Ongentys is not recommended during pregnancy and in women of childbearing potential not using contraception.
Danish: Ongentys bør ikke anvendes under graviditet eller til kvinder i den fertile alder, som ikke anvender sikker kontraception.
English: If Ongentys is discontinued it is necessary to adjust the dosing of the other antiparkinsonian treatments, especially levodopa, to achieve a sufficient level of control of the symptoms.
Danish: Hvis Ongentys seponeres, skal doseringen af andre antiparkinsonmidler justeres, især af levodopa, for at opnå tilstrækkelig symptomkontrol.
English: In both studies, 783 patients were treated with 25 mg or 50 mg of opicapone or placebo.
Danish: 783 patienter blev behandlet med 25 mg eller 50 mg opicapon eller placebo i de to studier.
English: Combination of opicapone and MAO inhibitors could result in inhibition of the majority of the pathways responsible for the metabolism of catecholamines.
Danish: Kombination af opicapon og MAO-hæmmere kan resultere i hæmning af de fleste af de processer, der er ansvarlige for metaboliseringen af katekolaminer.
English: A single dose study with opicapone 25 mg showed an average increase of 30 % in the rate, but not the extent, of exposure to repaglinide (a CYP2C8 substrate), when the two drugs were co-administered.
Danish: Et enkeltdosisstudie med 25 mg opicapon viste en gennemsnitlig stigning på 30 % i hastigheden, men ikke omfanget, af eksponeringen for repaglinid (et CYP2C8-substrat), når de to stoffer blev administreret samtidigt.
English: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugal (only for outer packaging)
Danish: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugal (kun på den ydre emballage)
English: Opicapone reduced CYP2C9 activity through competitive / mixed type mode of inhibition.
Danish: Opicapon reducerede CYP2C9-aktivitet ved kompetitiv hæmning / hæmning af blandet type.
English: OPA/Al/PVC//Al blisters containing 10 or 30 capsules.
Danish: OPA/Al/PVC//Al-blistre med 10 eller 30 kapsler.
English: Orthostatic Hypotension
Danish: Ortostatisk hypotension
English: Tell your doctor if you are taking: - medicines for depression or anxiety such as venlafaxine, maprotiline and desipramine.
Danish: Fortæl lægen, hvis du tager: - lægemidler til behandling af depression eller angst, som f.eks. venlafaxin, maprotilin og desipramin.
English: Phaeochromocytoma, paraganglioma, or other catecholamine secreting neoplasms.
Danish: Fæokromocytom, paragangliomer eller andre katekolaminproducerende neoplasmer.
English: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugal tel: +351 22 986 61 00 fax: +351 22 986 61 90 e-mail: info@bial.com
Danish: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugal tlf.: +351 22 986 61 00 fax: +351 22 986 61 90 e-mail: info@bial.com
English: Your doctor may need to reconsider your treatment.
Danish: Lægen kan tage din behandling op til overvejelse.
English: A second study conducted showed that, at steady state, opicapone 50 mg had no effect on repaglinide systemic exposure.
Danish: Et andet udført studie viste, at opicapon 50 mg ikke havde nogen effekt ved steady state på den systemiske eksponering for repaglinid.
English: The European Medicines Agency has waived the obligation to submit the results of studies with opicapone in all subsets of the paediatric population with Parkinson's disease and motor fluctuations (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med opicapon i alle undergrupper af den pædiatriske population ved Parkinsons sygdom (se pkt.
English: In in vitro studies in human hepatic microsomes, minor inhibition of CYP1A2 and CYP2B6 was observed.
Danish: Ved in vitro-studier i humane levermikrosomer blev der observeret en mindre hæmning af CYP1A2 og CYP2B6.
English: - The active substance is opicapone.
Danish: - Aktivt stof: Opicapon.
English: Ongentys is to be administered as an adjunct to levodopa treatment.
Danish: Ongentys skal administreres som supplement til levodopa-behandling.
English: Table 3 - OFF-time responder rates at endpoint Response type
Danish: Tabel 3 - Andelen af OFF-tidsrespondenter ved endepunkt Responstype
English: The difference in LS mean change in OFF-time of opicapone 50 mg to entacapone was -24.8 minutes and non-inferiority of opicapone 50 mg to entacapone was demonstrated (95% confidence interval: -61.4, 11.8).
Danish: Forskellen i gennemsnitlig ændring (LS) i OFF-tid mellem opicapon 50 mg og entacapon var -24,8 minutter, og der blev vist non-inferioritet mellem opicapon 50 mg og entacapon (95 % konfidensinterval: -61,4; 11,8).
English: Opicapone may, together with levodopa, cause dizziness, symptomatic orthostatism and somnolence.
Danish: Opicapon sammen med levodopa kan forårsage svimmelhed, symptomatisk ortostatisme og døsighed.
English: Ongentys is for use in adults who are already taking medicines containing levodopa and DOPA decarboxylase inhibitors.
Danish: Ongentys er beregnet til brug til voksne, som allerede tager lægemidler indeholdende levodopa og DOPAdecarboxylasehæmmer.
English: Following administration of a single oral dose of 14C-opicapone, the main excretion route of opicapone and its metabolites was faeces, accounting for 58.5% to 76.8% of the administered radioactivity (mean 67.2%).
Danish: Efter administration af en enkelt oral dosis 14C-opicapon var den primære udskillelsesvej for opicapon og dets metabolitter fæces, der tegnede sig for 58,5-76,8 % af den administrerede radioaktivitet (gennemsnit 67,2 %).
English: If you stop taking Ongentys
Danish: Hvis du holder op med at tage Ongentys
English: It is unknown whether opicapone or its metabolites are excreted in human milk.
Danish: Det er ukendt, om opicapon/metabolitter udskilles i human mælk.
English: 10 hard capsules 30 hard capsules 90 hard capsules
Danish: 10 hårde kapsler 30 hårde kapsler 90 hårde kapsler
English: It is used to treat Parkinson's disease and associated movement problems.
Danish: Lægemidlet bruges til behandling af Parkinsons sygdom og hermed forbundne bevægelsesproblemer.
English: There is limited experience with opicapone when used concomitantly with tricyclic antidepressants and noradrenaline re-uptake inhibitors (e.g. venlafaxine, maprotiline and desipramine).
Danish: Der er begrænset erfaring med opicapon, når det anvendes sammen med tricykliske antidepressiva og noradrenalin-genoptagelseshæmmere (f.eks. venlafaxin, maprotilin og desipramin).
English: History of neuroleptic malignant syndrome and/or non-traumatic rhabdomyolysis.
Danish: Anamnese med malignt neuroleptikasyndrom og/eller non-traumatisk rabdomyolyse.
English: To reduce levodopa-related dopaminergic adverse reactions (e.g. dyskinesia, hallucinations, nausea, vomiting and orthostatic hypotension), it is often necessary to adjust the daily dose of levodopa by extending the dosing intervals and/or reducing the amount of levodopa per dose within the first days to first weeks after initiating treatment with Ongentys, according to the clinical condition of the patient (see section 4.2).
Danish: For at reducere levodopa-relaterede dopaminerge bivirkninger (f.eks. dyskinesier, hallucinationer, kvalme, opkastning og ortostatisk hypotension) vil det ofte være nødvendigt at justere den daglige levodopadosis ved at forlænge doseringsintervallerne og/eller reducere mængden af levodopa pr. dosis i løbet af de første dage til uger efter påbegyndelse af Ongentys-behandling.
English: Ongentys should be taken preferably at bedtime.
Danish: Ongentys skal helst tages ved sengetid.
English: What you need to know before you take Ongentys Do not take Ongentys:
Danish: Det skal du vide, før du begynder at tage Ongentys Tag ikke Ongentys:
English: Opicapone in association with levodopa may have major influence on the ability to drive and use machines.
Danish: Opicapon i kombination med levodopa kan i væsentlig grad påvirke evnen til at føre motorkøretøj og betjene maskiner.
English: If not sufficient to manage the adverse events, the opicapone dose could then be down titrated.
Danish: Hvis dette ikke var tilstrækkeligt til at håndtere bivirkningerne, kunne opicapondosis herefter titreres ned.
English: CI = confidence interval; LS mean = least square mean; N = number of non-missing values; OPC = opicapone.
Danish: CI = konfidensinterval, LS-gennemsnit = gennemsnit beregnet efter mindste kvadraters metode (least square mean), N = antal uden manglende værdier, OPC = opicapon.
English: The patient should not take an extra dose to make up for the missed dose.
Danish: Patienten må ikke tage en dobbeltdosis som erstatning for den glemte dosis.
English: 10 hard capsules 30 hard capsules
Danish: 10 hårde kapsler 30 hårde kapsler
English: The pharmacokinetics of opicapone was not directly evaluated in subjects with chronic renal impairment.
Danish: Opicapons farmakokinetik blev ikke evalueret direkte hos forsøgspersoner med kronisk nyreinsufficiens.
English: Abdominal distention, Abdominal pain, Abdominal pain upper, Dyspepsia
Danish: Abdominal distension, abdominalsmerter, øvre abdominalsmerter, dyspepsi
English: BIAL - Portela & Cª, S.A. Tél/Tel/Teл./Tlf/Τηλ/Sími/Puh: + 351 22 986 61 00
Danish: Tél/Tel/Teл./Tlf/Τηλ/Sími/Puh: + 351 22 986 61 00
English: However, an evaluation with 50 mg opicapone was performed in subjects included in both phase 3 studies with GFR/1.73 m2 <60 mL/min (i.e. moderately decreased renal elimination capacity), and using pooled BIA 9-1103 data (major metabolite of opicapone).
Danish: Der blev dog gennemført en evaluering med 50 mg opicapon hos forsøgspersoner med GFR/1,73 m2 < 60 ml/min (dvs. moderat reduceret nyreeliminationskapacitet) inkluderet i de 2 fase 3-studier ved brug af puljede BIA 9-1103-data (opicapons hovedmetabolit).
English: Ongentys is for oral use.
Danish: Ongentys er til oral anvendelse (gennem munden).
English: If you forget to take Ongentys
Danish: Hvis du har glemt at tage Ongentys
English: Entacapone (N=122)
Danish: Entacapon (N=122)
English: Many of the side effects can be managed by your doctor adjusting your levodopa medicine.
Danish: Lægen kan behandle mange af bivirkningerne ved at justere dosis af din levodopa-medicin.
English: Your doctor may need to adjust your treatment; - medicines to treat asthma such as rimiterole or isoprenaline.
Danish: Lægen kan eventuelt justere din behandling; - lægemidler til behandling af astma, som f.eks. rimiterol eller isoprenalin.
English: There is no experience taking Ongentys and safinamide together.
Danish: Der er ingen erfaring med samtidig behandling med Ongentys og safinamid.
English: If unacceptable dopaminergic adverse events were seen, the levodopa dose was to be adjusted.
Danish: Hvis der opstod uacceptable dopaminerge bivirkninger, skulle levodopadosis justeres.
English: There were 60 patients in the combined Phase 3 studies who were predominantly using controlled-release levodopa (i.e. >50% of their levodopa/DDCI formulations), 48 of whom were treated solely with controlled-release formulations of levodopa.
Danish: Der var 60 patienter i de kombinerede fase 3studier, som overvejende anvendte levodopa med kontrolleret frigivelse (det vil sige > 50 % af deres levodopa/DDCI-formuleringer).
English: België/Belgique/Belgien/България/Česká republika/ Danmark/Deutschland/Eesti/Ελλάδα/France/
Danish: België/Belgique/Belgien/България/Česká republika/ Danmark/Deutschland/Eesti/Ελλάδα/France/ Hrvatska/Ireland/Ísland/Italia/Κύπρος/Latvija/
English: The most abundant peaks in plasma after a single-dose of 100 mg 14C-opicapone are metabolites BIA 9-1103 (sulphate) and BIA 9-1104 (methylated), 67.1 and 20.5% of radioactive AUC respectively.
Danish: De højeste toppe i plasma efter en enkeltdosis af 100 mg 14C-opicapon var metabolitterne BIA 9-1103 (sulfat) og BIA 9-1104 (metyleret) med AUC'er for radioaktivitet på henholdsvis 67,1 og 20,5 %.
English: Removal of opicapone by gastric lavage and/or inactivation by administering activated charcoal should be considered.
Danish: Det bør overvejes at fjerne opicapon ved skylning af mavesækken og/eller inaktivere opicapon ved hjælp af aktivt kul.
English: Opicapone demonstrated clinical efficacy superior to placebo during the double-blind treatment, both for the primary efficacy variable used in both pivotal studies, i.e. reduction in OFF-time (Table 2), the proportion of OFF-time responders (i.e. a subject who had a reduction in OFF-time of at least 1 hour from baseline to endpoint) (Table 3) and for most diary derived secondary endpoints.
Danish: Opicapon viste superior klinisk effekt i forhold til placebo i løbet af den dobbeltblinde behandling, både for den primære virkningsvariable, der blev brugt i begge pivotalstudier, dvs. reduktion i OFF-tid (tabel 2), andelen af OFF-tidsrespondenter, (dvs. forsøgspersoner, der havde en reduktion i OFF-tid på mindst 1 time fra baseline til endepunkt) (tabel 3), og for de fleste dagbogsafledte sekundære endepunkter.
English: An in vitro study showed opicapone inhibited CYP2C8 activity.
Danish: Et in vitro-studie viste, at opicapon hæmmede CYP2C8-aktivitet.
English: Talk to your doctor or pharmacist before taking Ongentys: - if you have severe liver problems and suffered from loss of appetite, weight loss, weakness, or exhaustion within a short period of time.
Danish: Kontakt lægen eller apotekspersonalet, før du tager Ongentys: - hvis du har alvorlige leverproblemer og lider af appetitløshed, vægttab eller svaghed, eller hvis du hurtigt bliver udmattet.
English: There is no relevant use of Ongentys in the paediatric population with Parkinson's disease and motor fluctuations.
Danish: Det er ikke relevant at anvende Ongentys til Parkinsons sygdom med motoriske fluktuationer hos den pædiatriske population.
English: Tel:+351 22 986 61 00
Danish: Tlf.: +351 22 986 61 00
English: Your doctor may need to adjust your treatment; - safinamide used for Parkinson's disease.
Danish: Lægen kan eventuelt justere din behandling; - safinamid til behandling af Parkinsons sygdom.
English: BIA 9-1103, its major metabolite, was transported by OATP1B1 and OATP1B3, and efflux transported by BCRP, but is not a substrate for the P-gp/MDR1 efflux transporter.
Danish: BIA 9-1103, dets hovedmetabolit, blev transporteret af OATP1B1 og OATP1B3 og effluks-transportøren BCRP, men er ikke et substrat for P-gp/MDR1-efflukstransportøren.
English: Package leaflet: Information for the patient Ongentys 50 mg hard capsules opicapone This medicine is subject to additional monitoring.
Danish: Indlægsseddel: Information til patienten Ongentys 50 mg hårde kapsler opicapon Dette lægemiddel er underlagt supplerende overvågning.
English: Package leaflet: Information for the patient Ongentys 25 mg hard capsules opicapone This medicine is subject to additional monitoring.
Danish: Indlægsseddel: Information til patienten Ongentys 25 mg hårde kapsler opicapon Dette lægemiddel er underlagt supplerende overvågning.
English: Opicapone is a weak in vitro inhibitor of CYP2C8 and OATP1B1, whereas repaglinide is a sensitive CYP2C8 and OATP1B1 substrate.
Danish: Opicapon er en svag CYP2C8- og OATP1B1-hæmmer in vitro, hvorimod repaglinid er et følsomt CYP2C8- og OATP1B1-substrat.
English: No dose adjustment is necessary in patients with renal impairment, as opicapone is not excreted by the kidney (see section 5.2).
Danish: Dosisjustering er ikke nødvendig hos patienter med nyreinsufficiens, da opicapon ikke udskilles via nyrerne (se pkt.
English: Each hard capsule contains 171.9 mg of lactose (as monohydrate).
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver hård kapsel indeholder 171,9 mg lactose (som monohydrat).
English: Tricyclic antidepressants and noradrenaline re-uptake inhibitors
Danish: Tricykliske antidepressiva og noradrenalin-genoptagelseshæmmere
English: In vitro studies have shown that opicapone is not transported by OATP1B1, but is transported by OATP1B3, and efflux transported by P-gp and BCRP.
Danish: In vitro-studier har vist, at opicapon ikke transporteres af OATP1B1, men transporteres af OATP1B3 og effluks-transportørerne P-gp og BCRP.