FrancophonIA/ELRC3.0 huggingface dataset:
English: Continuous treatment with Duzallo decreases the frequency of gout flares.
Maltese: Trattament kontinwu b'Duzallo jnaqqas il-frekwenza ta' rkadar tal-gotta.
English: Oxypurinol, the major metabolite of allopurinol and itself therapeutically active, is excreted by the kidney in a similar way to urate.
Maltese: Oxypurinol, il-metabolit ewlieni ta' allopurinol u minnu stess terapewtikament attiv, jitneħħa mill-kliewi b'mod simili għall-urate.
English: Additional signs to look for include: o ulcers of the mouth, throat, nose, genitals, conjunctivitis (red and swollen eyes) o widespread blisters or peeling of the skin o flu-like symptoms Very rare - may affect up to 1 in 10,000 people - swelling of the lips, tongue, face, throat, difficulty swallowing or breathing or red-raised itchy skin/hives (angioedema) - Duzallo may affect your blood, which can cause bruising more easily than usual, or you may get a sore throat or other signs of an infection.
Maltese: Sinjali addizzjonali li wieħed għandu jfittex għalihom jinkudu: o ulċeri fil-ħalq, griżmejn, imnieħer, partijiet ġenitali u konġuntivite (għajnejn ħomor u minfuħin) o nfafet jew tqaxxir mifrux tal-ġilda o sintomi jixbħu l-influwenza Rari ħafna - - jistgħu jaffettwaw sa persuna 1 minn kull 10,000 - nefħa fix-xofftejn, ilsien, wiċċ, griżmejn, diffikultà biex tibla' jew tieħu nifs jew ġilda ħamra mqabbża bil-ħakk/ħorriqija (anġjoedema) - Duzallo jista' jaffettwa d-demm tiegħek, u dan jista' jwassal sabiex titbenġel iktar faċilment mis-soltu, jew li jkollok uġigħ fi griżmejk jew sinjali oħrajn ta' infezzjoni.
English: Oedema, general malaise, asthaenia
Maltese: Nawsja, rimettar u dijarea
English: Zolvix is available as an oral solution (25 mg/ml).
Maltese: Zolvix jiġi f'soluzzjoni orali (25 mg/ml).
English: Zolvix is a medicine that contains the active substance monepantel.
Maltese: Zolvix huwa mediċina li fih is-sustanza attiva monepantel.
English: Zolvix is given as a single dose of 2.5 mg per kilogram bodyweight.
Maltese: Zolvix jingħata bħala doża waħda ta' 2.5 mg għal kull kilogramm tal-piż tal-ġisem.
English: If you want more information on the basis of the CVMP recommendations, read the scientific discussion (also part of the EPAR).
Maltese: Jekk tixtieq iktar informazzjoni relatata mar-rakkomandazzjonijiet tas-CVMP, aqra d-diskussjoni xjentifika (parti mill-EPAR).
English: Monepantel is effective against nematodes resistant to other anthelmintics.
Maltese: Monepantel huwa effettiv kontra n-nematodi reżistenti għal antelmentiċi oħra.
English: Monepantel, is an anthelmintic, a substance that is active against helminths.
Maltese: Monepantel, huwa antelmintiku, sustanza li hi attiva kontra l-elminti.
English: The European Commission granted a marketing authorisation valid throughout the European Union, for Zolvix on 4 November 2009.
Maltese: Il-Kummissjoni Ewropea tat awtorizzazzjoni għat-tqegħid fis-suq valida fl-Unjoni Ewropea kollha għal Zolvix fl-4 ta' Novembru 2009.
English: The studies showed that Zolvix is effective against infections of all of the major gastrointestinal nematodes, including effectiveness against strains of parasites resistant to the currently available broad-spectrum anthelmintics.
Maltese: L-istudji wrew li Zolvix huwa effettiv kontra l-infezzjonijiet tan-nematodi gastrointestinali maġġuri kollha, fosthom l-effikaċja kontra t-tipi ta' parassiti reżistenti għall-ispettru wiesa'ta' antemiltiċi disponibbli attwalment.
English: What is the withdrawal period?
Maltese: X'benefiċċju wera Zolvix waqt l-istudji mwettqa?
English: What is Zolvix?
Maltese: X'inhu Zolvix?
English: Other information about Zolvix:
Maltese: Aktar tagħrif dwar Zolvix:
English: This summary was last updated in November 2013.
Maltese: Dan is-sommarju ġie aġġornat l-aħħar f'Novembru 2013.
English: Zolvix is effective against a wide range of worm species.
Maltese: Zolvix huwa effettiv kontra varjetà wiesa' ta' speċi ta' dud.
English: Monepantel blocks part of a receptor, the nicotinic acetylcholine receptor, that is specific to the nematodes.
Maltese: Monepantel jimblokka parti mir-riċettur, ir-riċettur nikotiniku aċetikolinu, li huwa speċifiku għan-nematodi.
English: Why has Zolvix been approved?
Maltese: Għaliex ġie approvat Zolvix?
English: The effectiveness of Zolvix has not been established in sheep weighing less than 10 kg and safety has not been established in sheep weighing less than 10 kg or under two weeks of age.
Maltese: L-effikaċja ta' Zolvix għadha ma ġietx stabbilita f'nagħaġ li jiżnu inqas minn 10 kg u s-sigurtà għadha ma ġietx stabbilita f'nagħaġ li jiżnu inqas minn 10 kg jew li għandhom inqas minn ġimagħtejn.
English: What is the risk associated with Zolvix?
Maltese: Għal xiex jintuża Zolvix?
English: How has Zolvix been studied?
Maltese: Kif ġie studjat Zolvix?
English: Helminths, also known as nematodes, are worm-like parasites that live in the gut of animals.
Maltese: L-elminti, magħrufa wkoll bħala nematodi, huma parassiti simili tad-dud li jgħixu fl-intestini tal-annimali.
English: In case of accidental ingestion medical advice should be sought immediately and the package leaflet or the label shown to the doctor.
Maltese: Informazzjoni dwar l-istatus tal-preskrizzjoni ta' dan il-prodott tista' tinstab fuq it-tikketta/il-pakkett ta' barra.
English: Users who are administering this medicine to sheep should wear protective gloves.
Maltese: L-utenti li qed jamministraw din il-mediċina lin-nagħaġ għandhom jilbsu ingwanti protettivi.
English: Zolvix is not authorised for use in lactating animals producing milk for human consumption.
Maltese: Zolvix mhux permess għall-użu f'annimali li jaħilbu u jipproduċu ħalib għall-konsum mill-bniedem
English: The New Zealand study and some additional studies compared the effectiveness of Zolvix to other anthelmintics.
Maltese: L-istudju ta' New Zealand u xi studji addizzjonali qabblu l-effikaċja ta' Zolvix ma' antelmentiċi oħra.
English: The CVMP concluded that the benefits of Zolvix exceed the risks for the approved indications and recommended that Zolvix be given a marketing authorisation.
Maltese: Is-CVMP iddeċieda li l-benefiċċji ta' Zolvix huma akbar mir-riskji tiegħu meta jintuża għallindikazzjonijiet approvati u rrakkomanda li Zolvix jingħata awtorizzazzjoni għat-tqegħid fis-suq.
English: Zolvix is used for the treatment and control of worm infections of the gut and associated diseases in sheep.
Maltese: Dan id-dokument ma jistax jissostitwixxi diskussjoni wiċċ imb wiċċ mal-veterinarju tiegħek.
English: In the studies, the effectiveness of Zolvix was measured by looking for parasite eggs in the sheep faeces at different time points during the trials.
Maltese: Saru numru ta' studji fil-laboratorju u provi kliniċi fuq il-post f'diveri pajjiżi.
English: The CHMP having considered the application is of the opinion that the risk-benefit balance is favourable to recommend the granting of the conditional marketing authorisation as further explained in the European Public Assessment Report.
Maltese: Is-CHMP, wara li kkunsidra l-applikazzjoni huwa tal-fehma li l-bilanċ bejn ir-riskju u l-benefiċċju huwa wieħed favorevoli biex jirrakkomanda l-għoti tal-awtorizzazzjoni għat-tqegħid fis-suq kondizzjonali kif spjegat aktar fir-Rapport Pubbliku Ewropew ta' Valutazzjoni.
English: ANNEX IV
Maltese: MILL-AĠENZIJA EWROPEA GĦALL-MEDIĊINI
English: ATC vet code: QP54AB52.
Maltese: QP54AB52.
English: Store below 30 °C.
Maltese: Aħżen taħt it-30 °C.
English: Colorants: Sunset Yellow FCF (E110), Allura Red (E129), Indigo Carmine (E132).
Maltese: Koloranti: Sunset Yellow FCF (E110), Allura Red (E129), Indigo Carmine (E132).
English: 1 tablet 3 tablets 6 tablets
Maltese: 3 pilloli 6 pilloli
English: Pharmacotherapeutic group: antiparasitic products, moxidectin combinations.
Maltese: Grupp farmako-terapewtiku: prodotti anti-parassitarji, kombinazzjonijiet bil-moxidectin.
English: Pyrantel is a nicotinic acetylcholine (ACh) channel receptor (nAChR) agonist.
Maltese: Pyrantel huwa nicotinic acetylcholine (ACh) channel receptor (nAChR) agonist.
English: Sarolaner, moxidectin, pyrantel (as embonate)
Maltese: Sarolaner, moxidectin, pyrantel (bħala embonate)
English: pyrantel (as embonate) (mg)
Maltese: pyrantel (bħala embonate) (mg)
English: Butylhydroxytoluene (E321) Pigment blend 018 (E110, E129, E132) Hydroxypropylcellulose Silica, colloidal anhydrous Magnesium stearate Maize starch
Maltese: Butylhydroxytoluene (E321) Pigment blend 018 (E110, E129, E132) Hydroxypropylcellulose Silica, colloidal anhydrous Magnesium stearate Lamtu tal-qamħirrum Zokkor tal-pastiċċar Glucose, likwidu
English: Manufacturer responsible for batch release: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg GERMANY
Maltese: Manifattur responsabbli għall-ħrug tal-lott: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg IL-ĠERMANJA
English: Date of first authorisation: 17/09/2019
Maltese: DATA TAL-EWWEL AWTORIZZAZZJONI / TIĠDID TAL-AWTORIZZAZZJONI Data tal-ewwel awtorizzazzjoni: 17/09/2019
English: Lactose monohydrate Sodium starch glycolate type A Meglumine
Maltese: Sodium starch glycolate tip A Meglumine
English: − Toxocara canis immature adults (L5) and adults;
Maltese: − Toxocara canis adulti mmaturi (L5) u adulti;
English: Sarolaner is an acaricide and insecticide belonging to the isoxazoline family.
Maltese: Sarolaner huwa akkariċida u insettiċida tal-familja isoxazoline.
English: Macrocyclic lactones including moxidectin have been shown to be substrates for p-glycoprotein.
Maltese: Il-macrocyclic lactones inkluż il-moxidectin intwerew li huma substrati għall-p-glycoprotein.
English: Gastrointestinal nematodes
Maltese: Nematodi gastro-intestinali
English: − The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Maltese: − Il-prodott mediċinali veterinarju jista' jintuża bħala parti minn strateġija ta' trattament għallkontroll ta' flea allergy dermatitis (FAD).
English: Pyrantel is active against immature stages (L5) and adults of Toxocara canis, adults of Ancylostoma caninum, Toxascaris leonina and Uncinaria stenocephala.
Maltese: Pyrantel huwa attiv kontra stadji immaturi (L5) u adulti ta' Toxocara canis, adulti ta' Ancylostoma caninum, Toxascaris leonina and Uncinaria stenocephala.
English: − Ancylostoma caninum L4 larvae, immature adults (L5) and adults;
Maltese: − Ancylostoma caninum larvae L4, adulti immaturi (L5) u adulti;
English: − Uncinaria stenocephala adults.
Maltese: − Toxascaris leonina adulti; − Uncinaria stenocephala adulti.
English: Wheat germ
Maltese: TAGĦRIF
English: EU/2/19/243/010 (24 mg / 0.48 mg / 100 mg, 1 tablet) EU/2/19/243/011 (24 mg / 0.48 mg / 100 mg, 3 tablets) EU/2/19/243/012 (24 mg / 0.48 mg / 100 mg, 6 tablets) EU/2/19/243/013 (48 mg / 0.96 mg / 200 mg, 1 tablet) EU/2/19/243/014 (48 mg / 0.96 mg / 200 mg, 3 tablets) EU/2/19/243/015 (48 mg / 0.96 mg / 200 mg, 6 tablets) EU/2/19/243/016 (72 mg / 1.44 mg / 300 mg, 1 tablet) EU/2/19/243/017 (72 mg / 1.44 mg / 300 mg, 3 tablets) EU/2/19/243/018 (72 mg / 1.44 mg / 300 mg, 6 tablets)
Maltese: EU/2/19/243/009 (12 mg / 0.24 mg / 50 mg, 6 pilloli) EU/2/19/243/010 (24 mg / 0.48 mg / 100 mg, pillola) EU/2/19/243/011 (24 mg / 0.48 mg / 100 mg, 3 pilloli) EU/2/19/243/012 (24 mg / 0.48 mg / 100 mg, 6 pilloli) EU/2/19/243/013 (48 mg / 0.96 mg / 200 mg, pillola) EU/2/19/243/014 (48 mg / 0.96 mg / 200 mg, 3 pilloli) EU/2/19/243/015 (48 mg / 0.96 mg / 200 mg, 6 pilloli) EU/2/19/243/016 (72 mg / 1.44 mg / 300 mg, pillola) EU/2/19/243/017 (72 mg / 1.44 mg / 300 mg, 3 pilloli) EU/2/19/243/018 (72 mg / 1.44 mg / 300 mg, 3 pilloli)
English: Maintenance of the efficacy of macrocyclic lactones is critical for Dirofilaria immitis control.
Maltese: Il-manteniment tal-effikaċja ta' macrocyclic lactones hija kritika għallkontroll ta' Dirofilaria immitis.
English: − For the treatment of flea infestations (Ctenocephalides felis and Ctenocephalides canis).
Maltese: − Għat-trattament ta' infestazzjonijiet tal-briegħed (Ctenocephalides felis u Ctenocephalides canis).
English: Sarolaner blocks GABA- and glutamate-gated chloride channels in the central nervous system of insects and acarines.
Maltese: Sarolaner jimblokka l-GABA- u l-glutamate-gated chloride channels tas-sistema nervuża centrali tal-insetti u tal-akkaridi.
English: Moxidectin is a second-generation macrocyclic lactone of the milbemycin family.
Maltese: Moxidectin huwa macrocyclic lactone tat-tieni ġenerazzjoni tal-familja tal-milbemycin.
English: − For the prevention of heartworm disease (Dirofilaria immitis);
Maltese: − Għall-prevenzjoni ta' mard tal-heartworm (Dirofilaria immitis);
English: Tablet strength 72 mg/1.44 mg/300 mg
Maltese: 72 mg/1.44 m g/300 mg
English: sarolaner 3 mg/moxidectin 0.06 mg/pyrantel (as embonate) 12.5 mg sarolaner 6 mg/moxidectin 0.12 mg/pyrantel (as embonate) 25 mg sarolaner 12 mg/moxidectin 0.24 mg/pyrantel (as embonate) 50 mg sarolaner 24 mg/moxidectin 0.48 mg/pyrantel (as embonate) 100 mg sarolaner 48 mg/moxidectin 0.96 mg/pyrantel (as embonate) 200 mg sarolaner 72 mg/moxidectin 1.44 mg/pyrantel (as embonate) 300 mg
Maltese: 12 mg/pyrantel (bħala embonate) 25 mg sarolaner 12 mg/moxidectin 0.24 mg/pyrantel (bħala embonate) 50 mg sarolaner 24 mg/moxidectin 0.48 mg/pyrantel (bħala embonate) 100 mg sarolaner 48 mg/moxidectin 0.96 mg/pyrantel (bħala embonate) 200 mg sarolaner 72 mg/moxidectin 1.44 mg/pyrantel (bħala embonate) 300 mg
English: Sarolaner does not interact with known insecticidal binding sites of nicotinic or other GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins, and cyclodienes.
Maltese: Sarolaner ma jinteraġixxix ma' siti t'abbinar t'insettiċidi magħrufa ta' nikotiniċi jew GABAerġiċi oħrajn bħal neonicotinoids, fiproles, milbemycins, avermectins u cyclodienes.
English: Ectoparasites
Maltese: Ettoparassiti
English: Prevention of heartworm disease and angiostrongylosis:
Maltese: Prevenzjoni ta' mard tal-heartworm u anġjostronġilożi:
English: (L5) stages of Angiostrongylus vasorum.
Maltese: ta' Dirofilaria immitis u stadji mmaturi (L5) ta' Angiostrongylus vasorum.
English: 1.25-2.5 kg >2.5-5 kg >5-10 kg >10-20 kg >20-40 kg >40-60 kg >60 kg
Maltese: >5-10 kg >10-20 kg >20 -40 kg >40-60 kg >60 kg
English: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt Baden-Wuerttemberg
Maltese: Otto-Hahn-Str., Plankstadt
English: Moxidectin is slowly eliminated from plasma (half-life of approximately 11 days) via biliary excretion and elimination through the faeces with minor contributions of metabolic clearance.
Maltese: Moxidectin huwa eliminat bil-mod mill-plażma half life ta' bejn wieħed u ieħor 11-il jum) permezz ta' eliminazzjoni mill-marrara u mal-ippurgar b'kontribuzzjoni minuri għal tneħħija metabolika.
English: Sarolaner is slowly eliminated from plasma (half-life of approximately 12 days) via biliary excretion and elimination through the faeces with minor contributions of metabolic clearance.
Maltese: Sarolaner huwa eliminat bil-mod mill-plażma half life ta' bejn wieħed u ieħor 12-il jum) permezz ta' eliminazzjoni mill-marrara u mal-ippurgar b'kontribuzzjoni minuri għal tneħħija metabolika.
English: Treatment of flea and tick infestations and gastrointestinal nematodes:
Maltese: Trattament ta' infestazzjonijiet ta' briegħed u qurdien u nematodi gastro-intestinali:
English: Tablet strength 48 mg/0.96 mg/200 mg
Maltese: 48 mg/0.96 mg/200 mg
English: Pyrantel embonate is poorly absorbed and the absorbed portion has a tmax of 1.5 hours and half-life of 7.7 hours.
Maltese: Pyrantel embonate huwa assorbit mill-anqas u l-parti assorbita għandha tmax ta' siegħa u nofs u halflife ta' 7.7 sigħat.
English: EU/2/19/243/001 (3 mg / 0.06 mg / 12.5 mg, 1 tablet) EU/2/19/243/002 (3 mg / 0.06 mg / 12.5 mg, 3 tablets) EU/2/19/243/003 (3 mg / 0.06 mg / 12.5 mg, 6 tablets) EU/2/19/243/004 (6 mg / 0.12 mg / 25 mg, 1 tablet) EU/2/19/243/005 (6 mg / 0.12 mg / 25 mg, 3 tablets) EU/2/19/243/006 (6 mg / 0.12 mg / 25 mg, 6 tablets) EU/2/19/243/007 (12 mg / 0.24 mg / 50 mg, 1 tablet) EU/2/19/243/008 (12 mg / 0.24 mg / 50 mg, 3 tablets) EU/2/19/243/009 (12 mg / 0.24 mg / 50 mg, 6 tablets)
Maltese: EU/2/19/243/001 (3 mg / 0.06 mg / 12.5 mg, pillola) EU/2/19/243/002 (3 mg / 0.06 mg / 12.5 mg, 3 pilloli) EU/2/19/243/003 (3 mg / 0.06 mg / 12.5 mg, 6 pilloli) EU/2/19/243/004 (6 mg / 0.
English: For dogs with, or at risk from, mixed external and internal parasitic infestations.
Maltese: Għal klieb b'infestazzjonijiet jew f'riskju ta' infestazzjonijiet imħallta ta' parassiti esterni u interni.
English: Tablet strength 24 mg/0.48 mg/100 mg
Maltese: 24 mg/0.48 m g/100 mg
English: Moxidectin is active against adults of Toxocara canis, L4 larvae and immature stages (L5) of Ancylostoma caninum, L4 of Dirofilaria immitis and immature stages (L5) of Angiostrongylus vasorum.
Maltese: Moxidectin huwa attiv kontra Toxocara canis adulti, larve L4 u stadji mmaturi (L5) ta' Ancylostoma caninum, L4
English: chewable tablet
Maltese: Pillola waħda
English: Simparica Trio 1.25-2.5 kg Simparica Trio >2.5-5 kg Simparica Trio >5-10 kg Simparica Trio >10-20 kg Simparica Trio >20-40 kg Simparica Trio >40-60 kg
Maltese: Simparica Trio >5-10 kg Simparica Trio >10-20 kg Simparica Trio >20-40 kg Simparica Trio >40-60 kg
English: Moxidectin is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 2.4 hours (tmax) after administration and with 66.9% bioavailability.
Maltese: Moxidectin jiġi assorbit b'mod sistemiku faċilment u malajr wara dożaġġ orali, u jilħaq l-ogħla konċentrazzjoni fil-plażma fi żmien 2.4 sigħat (tmax) wara amminstrazzjoni u b'bijodisponibilità ta' 66.9%.
English: Therefore, during treatment with the veterinary medicinal product, other products that can inhibit pglycoprotein (e.g. cyclosporine, ketoconazole, spinosad, verapamil) should only be used concomitantly according to the benefit-risk assessment of the responsible veterinarian.
Maltese: Għalhekk, waqt it-trattament bil-prodott mediċinal veterinarju, prodotti oħra li jistgħu jfixklu l-pglycoprotein (eż. cyclosporine, ketoconazole, spinosad, verapamil) għandhom jintużaw fl-istess ħin biss skont il-valutazzjoni tal-benefiċju u r-riskju mill-veterinarju responsabbli.
English: The veterinary medicinal product is exclusively indicated when use against ticks or fleas and gastrointestinal nematodes is indicated at the same time.
Maltese: Ilprodott mediċinali veterinarju huwa indikat esklussivament meta l-użu kontra l-qurdien jew ilbriegħed u nematodi gastro-intestinali huwa indikat fl-istess ħin.
English: The veterinary medicinal product has immediate and persistent flea killing activity against new infestations for 5 weeks;
Maltese: Il-prodott mediċinali veterinarju għandu attività immedjata u persistenti li toqtol ilbriegħed kontra infestazzjonijiet ġodda għal 5 ġimgħat ;
English: Pyrantel mimics the agonist effects of ACh through high affinity binding to subtype specific ionophoric nAChRs in nematodes, while not binding at muscarinic mAChRs.
Maltese: Pyrantel jikkopja leffetti agonistoċi ta' ACh b'abbinar qawwi mas-subtype specific ionophoric nAChRs fin-nematodi, waqt li ma jabbinax mal-muscarinic mAChRs.
English: Excipients:
Maltese: Ingredjenti oħra:
English: moxidectin (mg)
Maltese: Piż tal-ġisem (kg)
English: Sarolaner is active against adult fleas (Ctenocephalides felis and Ctenocephalides canis) as well as several tick species such as Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus.
Maltese: qurdien bħal Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus u Rhipicephalus sanguineus.
English: Dogs in areas endemic for heartworm (or those which have travelled to endemic areas) may be infected with adult heartworms.
Maltese: Klieb f'żoni endemiċi (jew dawk li vvjaġġaw lejn żoni endemiċi) jistgħu jkunu infettati b'heartworms adulti.
English: Tablet strength 12 mg/0.24 mg/50 mg
Maltese: 12 mg/0.24 m g/50 mg
English: In particular, both active substances contribute to the overall efficacy against the gastrointestinal nematodes Ancylostoma caninum and Toxocara canis.
Maltese: B'mod partikulari, iż-żewġ sustanzi attivi jikkontribwixxu għall-effikaċja kompleta kontra n-nematodi gastro-intestinali Ancylostoma caninum u Toxocara canis.
English: A reddish-brown colored, pentagon shaped tablet with rounded edges.
Maltese: Pillola lewn kannella fl-aħmar, b'forma pentagonali bl-ixfra irrotondjati.
English: Pyrantel is eliminated through faeces and the small absorbed portion is eliminated mainly via urine.
Maltese: Pyrantel jiġi eliminat mal-ippurgar u porzjon żgħir li jiġi assorbit jiġi eliminat laktar mal-urina
English: Sarolaner is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 3.5 hours (tmax) after administration with a high bioavailability of 86.7%.
Maltese: Sarolaner jiġi assorbit b'mod sistemiku faċilment u malajr wara dożaġġ orali, u jilħaq l-ogħla konċentrazzjoni fil-plażma fi żmien 3.5 sigħat (tmax) wara amminstrazzjoni b'bijodisponibilità għolja ta' 86.7%.
English: The veterinary medicinal product has immediate and persistent tick killing activity for 5 weeks against Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus and for 4 weeks against Dermacentor reticulatus;
Maltese: Il-prodott mediċinali veterinarju għandu attività immedjata u persistenti li toqtol il-qurdien għal 5 ġimgħat kontra Ixodes hexagonus, Ixodes ricinus u Rhipicephalus sanguineus u għal 4 ġimgħat kontra Dermacentor reticulatus ;
English: Each tablet strength is available in pack sizes of 1, 3 or 6 tablets.
Maltese: Kull saħħa ta' pillola hija disponibbli f'pakketti ta' pillola waħda, 3 jew 6 pilloli.
English: Its principal mode of action is interfering with neuromuscular transmission at the level of the glutamate-gated chloride channels and, to a lesser extent, of GABA (gamma amino butyric acid)-gated channels.
Maltese: L-attività prinċipali tiegħu hija li jfixkel it-trażmissjoni newromuskolari fil-livell tal-glutamate-gated chloride channels u, b'mod anqas, tal- GABA (gamma amino butyric acid)-gated channels.
English: Special precautions for use in animals:
Maltese: Kodici ATC veterinarju:
English: In this fixed combination, moxidectin and pyrantel provide complementary anthelmintic efficacy through distinct mechanisms of action.
Maltese: F'din it-taħlita fissa, moxidectin u pyrantel joffru effikaċja antielminitka kumplimentari permezz ta' sistemi ta'attività distinti.
English: Simparica Trio chewable tablets sarolaner (mg)
Maltese: Simparica Trio pilloli li jintmagħdu sarolaner
English: Tablet strength 3 mg/0.06 mg/ 12.5 mg
Maltese: 3 mg/0.06 mg/12.5 mg
English: Tablet strength 3 mg/0.06 mg/12.5 mg
Maltese: 3 mg/0.06 mg/ 12.5 mg
English: A single treatment is efficacious for the treatment of gastrointestinal nematodes.
Maltese: Trattament wieħed huwa effikaċi għat-trattament ta' nematodi gastro-intestinali.
English: The veterinary medicinal product should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg of moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table:
Maltese: 024-0.048 mg/kg ta' moxidectin u 5-10 mg/kg ta' pyrantel skont it-tabella li ġejja:
English: Sarolaner exhibits higher functional potency to block insect/acarine receptors compared to mammalian receptors.
Maltese: Sarolaner juri qawwa funzjonali ogħla biex jimblokka r-reċetturi tal-insetti/akkaridi meta mqabbel mar-reċetturi tal-mammiferi.
English: Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg Simparica Trio chewable tablets for dogs >5-10 kg Simparica Trio chewable tablets for dogs >10-20 kg Simparica Trio chewable tablets for dogs >20-40 kg Simparica Trio chewable tablets for dogs >40-60 kg sarolaner/moxidectin/pyrantel
Maltese: Trio pilloli li jintmagħdu għal klieb >5-10 kg Simparica Trio pilloli li jintmagħdu għal klieb >10-20 kg Simparica Trio pilloli li jintmagħdu għal klieb >20-40 kg Simparica Trio pilloli li jintmagħdu għal klieb >40-60 kg sarolaner/moxidectin/pyrantel
English: For the treatment of gastrointestinal roundworm and hookworm infections:
Maltese: Għat-trattament ta' infezzjoijiet gastro-intestinali bir-roundworm u l-hookworm.