FrancophonIA/ELRC3.0 huggingface dataset:
English: Renal and urinary disorders uncommon acute renal failure, renal failure, nephrolithiasis, increased blood creatinine, proteinuria, bilirubinuria, dysuria, nocturia, pollakiuria rare decreased creatinine renal clearance
Slovenian: Bolezni sečil občasni akutna ledvična odpoved, ledvična odpoved, nefrolitiaza, povišan kreatinin v krvi, proteinurija, bilirubinurija, disurija, nikturija, polakisurija redki zmanjšan ledvični očistek kreatinina
English: Concomitant use of boosted darunavir and corticosteroids that are metabolised by CYP3A (e.g. fluticasone propionate or other inhaled or nasal corticosteroids) may increase the risk of development of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression.
Slovenian: Sočasna uporaba okrepljenega darunavirja in kortikosteroidov, ki se presnavljajo s CYP3A (npr.: flutikazonpropionat ali drugi inhalacijski oziroma nazalni kortikosteroidi) lahko zvečajo tveganje za pojav sistemskih kortikosteroidnih učinkov, vključno s Cushingovim sindromom in supresijo nadledvične žleze.
English: POWER 1 and POWER 2 are randomised, controlled trials comparing darunavir co-administered with ritonavir (600/100 mg twice daily) with a control group receiving an investigator-selected PI(s) regimen in HIV-1 infected patients who had previously failed more than 1 PI containing regimen.
Slovenian: POWER 1 in POWER 2 sta randomizirani, nadzorovani preskušanji, v katerih so zdravljenje z darunavirjem, skupaj z ritonavirjem (600/100 mg dvakrat na dan), primerjali s kontrolno skupino, v kateri so bolniki prejemali režim z zaviralci proteaz po izbiri raziskovalca, pri bolnikih, pri katerih je bil pred tem najmanj en režim z zaviralci proteaz neuspešen.
English: During the third trimester of pregnancy, cobicistat Cmax, AUC24h, and Cmin, were 27%, 49%, and 83% lower, respectively, as compared with postpartum.
Slovenian: V tretjem trimesečju nosečnosti so bile vrednosti Cmax, AUC24h, in Cmin kobicistata za 27%, 49% oziroma 83% nižje kot v obdobju po porodu.
English: Co-administration of boosted darunavir and amiodarone, bepridil, dronedarone, ivabradine, quinidine, or ranolazine is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba okrepljenega darunavirja z amjodaronom, bepridilom, dronedaronom, ivabradinom, kinidinom ali ranolazinom je kontraindicirana (glejte poglavje 4.3).
English: an up to five-fold increase was seen in a limited subset of subjects
Slovenian: Pri nekaterih preiskovancih je prišlo do največ 5-kratnega zvečanja izpostavljenosti pravastatinu.
English: A safe and effective dose of sildenafil for the treatment of pulmonary arterial hypertension co-administered with darunavir and low dose ritonavir has not been established.
Slovenian: Varnega in učinkovitega odmerka sildenafila (za zdravljenje pljučne arterijske hipertenzije) skupaj z darunavirjem v kombinaciji z majhnim odmerkom ritonavirja niso ugotovili.
English: Applicable to darunavir boosted with either ritonavir or cobicistat:
Slovenian: Darunavir, okrepljen z ritonavirjem ali s kobicistatom:
English: For information on cobicistat pharmacokinetic properties, consult the cobicistat Summary of Product Characteristics.
Slovenian: Za podatke o farmakokinetičnih lastnostih kobicistata glejte Povzetek glavnih značilnosti zdravila za kobicistat.
English: Concomitant use of darunavir/ritonavir and darunavir/cobicistat with lopinavir/ritonavir, rifampicin and herbal products containing St John's wort, Hypericum perforatum, is contraindicated (see section 4.5).
Slovenian: Sočasna uporaba učinkovin darunavir/ritonavir in darunavir/kobicistat s kombinacijo lopinavir/ritonavir, z rifampicinom in zdravili rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum), je kontraindicirana (glejte poglavje 4.5).
English: Concomitant use of colchicine and boosted darunavir may increase the exposure to colchicine.
Slovenian: Pri sočasni uporabi kolhicina in okrepljenega darunavirja se lahko zveča izpostavljenost kolhicinu.
English: If there is evidence of new or worsening liver dysfunction (including clinically significant elevation of liver enzymes and/or symptoms such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) in patients using darunavir/ritonavir, interruption or discontinuation of treatment should be considered promptly.
Slovenian: Če pri bolnikih, ki se zdravijo z zdraviloma darunavir/ritonavir, opazite znake o novih ali o poslabšanju obstoječih motenj v delovanju jeter (vključno s klinično pomembnim zvišanjem koncentracije jetrnih encimov in/ali simptomi kot so utrujenost, anoreksija, navzea, zlatenica, temen urin, boleča jetra, hepatomegalija), je nemudoma treba razmisliti o prekinitvi ali ukinitvi zdravljenja.
English: With Baseline CD4+ cell count (x 10
Slovenian: Z začetnim št. celic CD4+ (x 10
English: During the second trimester of pregnancy, cobicistat Cmax, AUC24h, and Cmin were 50%, 63%, and 83% lower, respectively, as compared with postpartum.
Slovenian: V drugem trimesečju nosečnosti so bile vrednosti Cmax, AUC24h, in Cmin kobicistata za 50%, 63%, oziroma 83% nižje kot v obdobju po porodu.
English: After therapy has been initiated, the dose or dosage form must not be changed or therapy must not be stopped without instruction of the doctor.
Slovenian: Brez zdravnikovega navodila med zdravljenjem ne smete spreminjati odmerka, farmacevtske oblike ali prekiniti zdravljenja.
English: In addition, pharmacokinetic modeling and simulation of darunavir exposures in paediatric patients across the ages of 3 to < 18 years confirmed the darunavir exposures as observed in the clinical studies and allowed the identification of weight-based darunavir/ritonavir once daily dosing regimens for paediatric patients weighing at least 15 kg that are either ART-naïve or treatment-experienced paediatric patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Slovenian: Farmakokinetični model in posnemanje izpostavljenosti darunavirju pri pediatričnih bolnikih starih 3 do < 18 let sta potrdila izpostavljenost darunavirju, opaženo v kliničnih preskušanjih, in na osnovi telesne mase določila odmerjanje zdravil darunavir/ritonavir enkrat na dan pri pediatričnih bolnikih s telesno maso najmanj 15 kg, ki še nimajo ali pa že imajo izkušnje z ART in so brez mutacij, povezanih z odpornostjo proti darunavirju (DRV-RAM)*, in imajo plazemsko koncentracijo HIV-1 RNK < 100.000 kopij/ml in število celic CD4+ ≥ 100 celic x 10
English: When darunavir is coadministered with a drospirenone-containing product, clinical monitoring is recommended due to the potential for hyperkalaemia.
Slovenian: Pri sočasni uporabi zdravila darunavir z zdravili, ki vsebujejo drospirenon je priporočljivo klinično spremljanje bolnika zaradi možne hiperkaliemije.
English: Skin and subcutaneous tissue disorders very common rash (including macular, maculopapular, papular, erythematous, pruritic rash, generalised rash, and allergic dermatitis)
Slovenian: Bolezni kože in podkožja zelo pogosti izpuščaj (vključno z makularnim, makulopapularnim, eritematoznim, pruritičnim, generaliziranim izpuščajem in alergijskim dermatitisom)
English: Co-administration is expected to reduce plasma concentrations of darunavir, ritonavir and cobicistat, which could lead to loss of therapeutic effect and possible development of resistance (see sections 4.4 and 4.5).
Slovenian: Pri sočasnem dajanju je pričakovati znižanje plazemske koncentracije darunavirja, ritonavirja in kobicistata, kar lahko vodi v izgubo terapevtskega učinka in razvoj odpornosti (glejte poglavji 4.4 in 4.5).
English: Alternative corticosteroids which are less dependent on CYP3A metabolism e.g. beclomethasone for intranasal or inhalational use should be considered, particularly for long term use.
Slovenian: O uporabi kortikosteroidov, ki so manj odvisni od presnove s CYP3A, npr. intranazalni ali inhalacijski beklometazon, pa je treba razmisliti, predvsem pri dolgotrajnem zdravljenju.
English: Concomitant use of darunavir with low dose ritonavir and corticosteroids that are metabolised by CYP3A (e.g. fluticasone propionate or other inhaled or nasal corticosteroids) may increase the risk of development of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression.
Slovenian: Sočasna uporaba darunavirja skupaj z majhnim odmerkom ritonavirja in s kortikosteroidi, ki se presnavljajo s CYP3A (npr.: flutikazonpropionat ali drugi inhalacijski oziroma nazalni kortikosteroidi) lahko zvečajo tveganje za pojav sistemskihkortikosteroidnih učinkov, vključno s Cushingovim sindromom in supresijo nadledvične žleze.
English: Darunavir Krka, co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection.
Slovenian: Zdravilo Darunavir Krka je v kombinaciji z majhnim odmerkom ritonavirja in z drugimi protiretrovirusnimi zdravili indicirano za zdravljenje bolnikov okuženih z virusom humane imunske pomanjkljivosti (HIV-1).
English: 450 milligram darunavir + 60 milligram ritonavir twice a day more than 40 kilograms*
Slovenian: 450 mg darunavirja + 60 mg ritonavirja dvakrat na dan več kot 40 kg*
English: Dasatinib Nilotinib Vinblastine Vincristine
Slovenian: ZDRAVILA Z DELOVANJEM NA NOVOTVORBE dasatinib nilotinib vinblastin vinkristin everolimus irinotekan
English: According to the TLOVR non-virologic failure censored algorithm 24 (30.0%) patients experienced virological failure, of which 17 (21.3%) patients were rebounders and 7 (8.8%) patients were nonresponders.
Slovenian: Od teh je pri 17 (21,3 %) prišlo do ponovnega poslabšanja, pri 7 (8,8 %) pa ni bilo odziva na zdravljenje.
English: Each film-coated tablet contains 400 mg or 800 mg darunavir.
Slovenian: Ena filmsko obložena tableta vsebuje 400mg ali 800 mg darunavirja.
English: Rash occurred more commonly in treatment-experienced patients receiving regimens containing darunavir/ritonavir + raltegravir compared to patients receiving darunavir/ritonavir without raltegravir or raltegravir without darunavir (see section 4.8).
Slovenian: Pri bolnikih z izkušnjami s protiretrovirusnim zdravljenjem, ki so prejemali režime darunavir/ritonavir + raltegravir, se je izpuščaj pojavljal pogosteje kot pri bolnikih, ki so prejemali režim darunavir/ritonavir brez raltegravirja ali raltegravir brez darunavirja (glejte poglavje 4.8).
English: concentrations of salmeterol.
Slovenian: Sočasna uporaba s plazemskih koncentracij salmeterola.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with boosted darunavir is not recommended.
Slovenian: Sočasna uporaba tadalafila (za zdravljenje pljučne arterijske hipertenzije) z okrepljenim darunavirjem ni priporočljiva.
English: During the clinical development program of raltegravir in treatment-experienced patients, rash, irrespective of causality, was more commonly observed with regimens containing darunavir/ritonavir + raltegravir compared to those containing darunavir/ritonavir without raltegravir or raltegravir without darunavir/ritonavir.
Slovenian: Med kliničnim razvojem raltegravirja pri bolnikih z izkušnjami s protiretrovirusnim zdravljenjem se je izpuščaj, ne glede na vzrok, pojavljal pogosteje pri režimu odmerjanja zdravil darunavir/ritonavir skupaj z raltegravirjem v primerjavi z režimom odmerjanja, ki je vključeval samo darunavir/ritonavir ali samo raltegravir.
English: The combination of rifapentine and boosted darunavir is not recommended.
Slovenian: Kombinacija rifapentina in okrepljenega darunavirja ni priporočljiva.
English: Based on theoretical considerations boosted darunavir is expected to increase the exposure of lomitapide when coadministered.
Slovenian: Glede na teoretična izhodišča je mogoče pričakovati, da okrepljen darunavir, kadar je sočasno uporabljen z lomitapidom zviša izpostavljenost lomitapidu.
English: (n=16)
Slovenian: d (-25; 16)
English: Dose for children of 3 years of age and above, weighing at least 15 kilograms who have not taken antiretroviral medicines before (your child's doctor will determine this) The doctor will work out the right once daily dose based on the weight of the child (see table below).
Slovenian: Odmerek za otroke, stare 3 leta ali več in s telesno maso najmanj 15 kg, ki še niso prejemali protiretrovirusnih zdravil (to bo določil otrokov zdravnik) Zdravnik bo določil dnevni odmerek na osnovi otrokove telesne mase (glejte spodnjo preglednico).
English: With Baseline HIV-1 RNA (copies/ml)
Slovenian: HIV-1 RNK (kopij/ml)
English: Hepatobiliary disorders common increased alanine aminotransferase uncommon hepatitis, cytolytic hepatitis, hepatic steatosis, hepatomegaly, increased transaminase, increased aspartate aminotransferase, increased blood bilirubin, increased blood alkaline phosphatase, increased gamma-glutamyltransferase
Slovenian: Bolezni jeter, žolčnika in žolčevodov pogosti povišanje koncentracije alanin-aminotransferaze občasni hepatitis, citolitični hepatitis, jetrna steatoza, hepatomegalija, povišana koncentracija transaminaz, povišanje koncentracije aspartataminotransferaze, povišana koncentracija bilirubina v krvi, povišana koncentracija alkalne fosfataze v krvi, povišana koncentracija gama-glutamiltransferaze
English: Concomitant systemic use of clotrimazole and boosted darunavir may increase plasma concentrations of darunavir and/or clotrimazole.
Slovenian: Sočasna sistemska uporaba klotrimazola in okrepljenega darunavirja lahko zviša plazemske koncentracije darunavirja in/ali klotrimazola.
English: Respiratory, thoracic and mediastinal disorders uncommon dyspnoea, cough, epistaxis, throat irritation rare rhinorrhoea
Slovenian: Bolezni dihal, prsnega koša in mediastinalnega prostora občasni dispneja, kašelj, epistaksa, draženje grla redki rinoreja
English: #, a comparable systemic exposure to sildenafil was observed for a single intake of 100 mg sildenafil alone and a single intake of 25 mg sildenafil co-administered with
Slovenian: V študiji medsebojnih delovanj# je bila sistemska izpostavljenost sildenafilu po zaužitju enkratnega odmerka 100 mg samega sildenafila in enkratnega odmerka 25 mg sildenafila skupaj z darunavirjem in
English: 21 ART-experienced HIV-1 infected paediatric patients aged from 3 to < 6 years and weighing 10 kg to < 20 kg (16 participants from 15 kg to < 20 kg) who received darunaviroral suspension with low dose ritonavir twice daily in combination with other antiretroviral agents.
Slovenian: - 21 sHIV-1 okuženih pediatričnih bolnikov, starih 3 do< 6 let in s telesno maso 10 kg do < 20 kg (16 preiskovancev s telesno maso 15 kg do < 20 kg), z izkušnjami z ART, ki so prejemali peroralno suspenzijo darunavirja skupaj z majhnim odmerkom ritonavirja dvakrat na dan in drugimi protiretrovirusnimi zdravili.
English: Darunavir Krka might increase sugar levels in the blood.
Slovenian: Zdravilo Darunavir Krka, lahko zviša koncentracijo sladkorja v krvi.
English: If antidepressants are co-administered with boosted darunavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Slovenian: Pri sočasni uporabi antidepresivov in okrepljenega darunavirja se priporoča titracija odmerka antidepresiva na podlagi klinične ocene učinka antidepresiva.
English: The combination product lopinavir/ritonavir (see section 4.5).
Slovenian: - Kombinacija zdravil lopinavir/ritonavir (glejte poglavje 4.5).
English: Dexamethasone may decrease plasma concentrations of darunavir.
Slovenian: Sistemsko dani deksametazon lahko zniža plazemske koncentracije darunavirja.
English: In the evening, take one 600 milligram Darunavir Krka tablet together with 100 milligram ritonavir.
Slovenian: - Zvečer vzemite eno tableto zdravila Darunavir Krka po 600 mg skupaj s 100 mg ritonavirja.
English: If efavirenz is to be used in combination with darunavir /ritonavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used (see section 4.4).
Slovenian: Če je treba kombinirati efavirenz in zdravili darunavir/ritonavir, je treba uporabljati režim darunavir/ritonavir 600/100 mg dvakrat na dan (glejte poglavje 4.4).
English: It is not recommended to alter the dose of ritonavir.
Slovenian: Odmerka ritonavirja ni priporočljivo spreminjati.
English: However, increased methadone dose may be necessary when concomitantly administered for a longer period of time due to induction of metabolism by ritonavir.
Slovenian: Zaradi indukcije metabolizma z ritonavirjem bo pri dolgotrajnejši sočasni uporabi morda potrebno zvečati odmerek metadona.
English: The metabolism of alfentanil is mediated via CYP3A, and may as such be inhibited by boosted darunavir.
Slovenian: Presnova alfentanila poteka preko CYP3A in jo lahko zavira okrepljen darunavir.
English: For additional clinical study results in ART-experienced adults and paediatric patients, refer to the Summary of Product Characteristics for Darunavir Krka 600 mg tablets.
Slovenian: Za dodatne rezultate kliničnih študij pri bolnikih z izkušnjami z ART glejte Povzetek glavnih značilnosti zdravila Darunavir Krka 600 mg tablete.
English: A lower and upper clinical cut-off of 10 and 40 were identified.
Slovenian: Določili so spodnjo (10) in zgornjo(40) mejno vrednost FC.
English: Do not combine Darunavir Krka with products that contain St John's wort (Hypericum perforatum).
Slovenian: Zdravila Darunavir Krka ne smete jemati sočasno z zdravili rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum).
English: Increased AST/ALT monitoring should be considered in patients with underlying chronic hepatitis, cirrhosis, or in patients who have pretreatment elevations of transaminases, especially during the first several months of darunavir/ritonavir treatment.
Slovenian: Pri bolnikih s kroničnim hepatitisom, cirozo in pri bolnikih, ki imajo pred zdravljenjem zvišane koncentracije transaminaz, je treba razmisliti o pogostejšem spremljanju koncentracij AST/ALT, kar še posebej velja v prvih mesecih zdravljenja z darunavirjem v kombinaciji z ritonavirjem.
English: The overall pharmacokinetic enhancement effect by ritonavir was an approximate 14-fold increase in the systemic exposure of darunavir when a single dose of 600 mg darunavir was given orally in combination with ritonavir at 100 mg twice daily.
Slovenian: Celokupni učinek farmakokinetične okrepitve z ritonavirjem je privedel do približno 14-kratnega zvečanja sistemske izpostavljenosti darunavirju pri peroralni uporabi enkratnega odmerka 600 mg darunavirja v kombinaciji z ritonavirjem v odmerku 100 mg dvakrat na dan.
English: #, a comparable systemic exposure to sildenafil was observed for a single intake of 100 mg sildenafil alone and a single intake of 25 mg sildenafil co-administered with darunavir and low dose ritonavir.
Slovenian: V študiji medsebojnih delovanj # je bila sistemska izpostavljenost sildenafilu po zaužitju enkratnega odmerka 100 mg samega sildenafila in enkratnega odmerka 25 mg sildenafila skupaj z darunavirjem in majhnim odmerkom ritonavirja
English: (inhibition of CYP450 enzymes)
Slovenian: (zaviranje encimov CYP450)
English: Co-administration of boosted darunavir with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Slovenian: Sočasna uporaba darunavirja z navedenimi antikoagulanti lahko zviša njihove koncentracije, kar lahko poveča tveganje za krvavitve.
English: Buprenorphine/naloxone 8/2 mg-16/4 mg once daily buprenorphine AUC ↓ 11% buprenorphine Cmin ↔ buprenorphine Cmax ↓ 8% norbuprenorphine AUC ↑ 46% norbuprenorphine Cmin ↑ 71% norbuprenorphine Cmax ↑ 36% naloxone AUC ↔ naloxone Cmin ND naloxone Cmax ↔
Slovenian: buprenorfin/nalokson 8/2 mg-16/4 mg enkrat na dan buprenorfin AUC ↓ 11 % buprenorfin Cmin ↔ buprenorfin Cmax ↓ 8 % norbuprenorfin AUC ↑ 46 % norbuprenorfin Cmin ↑ 71 % norbuprenorfin Cmax ↑ 36 % nalokson AUC ↔ nalokson Cmin ND nalokson Cmax ↔
English: Darunavir Krka with cobicistat or ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Slovenian: Zdravilo Darunavir Krka s kobicistatom ali ritonavirjem ni bilo preskušano v kombinaciji z vsemi zaviralci proteaz in se ne sme uporabljati skupaj z drugimi zaviralci proteaz HIV.
English: No dose adjustment is required for darunavir/ritonavir in patients with renal impairment (see sections 4.4 and 5.2).
Slovenian: Pri bolnikih z okvaro ledvic prilagajanje odmerka zdravil darunavir/ritonavir ni potrebno (glejte poglavji 4.4 in 5.2).
English: The interaction trial showed a comparable daily systemic exposure for rifabutin between treatment at 300 mg once daily alone and 150 mg once every other day in combination with darunavir/ritonavir (600/100 mg twice daily) with an about 10fold increase in the daily exposure to the active metabolite 25-O-desacetylrifabutin.
Slovenian: Preskušanje medsebojnih delovanj je pokazalo primerljivo sistemsko izpostavljenost rifabutinu pri zdravljenju samo s 300 mg rifabutina enkrat na dan in pri zdravljenju s 150 mg rifabutina vsak drugi dan v kombinaciji z zdraviloma darunavir/ritonavir (600/100 mgdvakrat na dan).
English: Since darunavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of the active substance.
Slovenian: Ker je darunavir v velikem odstotku vezan na beljakovine, je malo verjetno, da bi lahko s hemodializo odstranili pomembno količino učinkovine.
English: Darunavir Krka 400mg film-coated tabletsareavailable in bottlescontaining 30 film-coated tablets (1 bottleof 30 film-coated tablets), 60 film-coated tablets (2 bottlesof 30 film-coated tablets), 90 filmcoated tablets (3 bottlesof 30 film-coated tablets)and 180 film-coated tablets (6 bottlesof 30 filmcoated tablets)in a box.
Slovenian: Darunavir Krka 400 mg filmsko obložene tablete so na voljo v plastenkah po 30 filmsko obloženih tablet (1 plastenka po 30 filmsko obloženih tablet), 60 filmsko obloženih tablet (2 plastenki po 30 filmsko obloženih tablet), 90 filmsko obloženih tablet (3 plastenke po 30 filmsko obloženih tablet) in 180 filmsko obloženih tablet (6 plastenk po 30 filmsko obloženih tablet), v škatli.
English: Boosted darunavir can be coadministered with H2-receptor antagonists without dose adjustments.
Slovenian: Okrepljen darunavir lahko uporabljamo sočasno z antagonisti receptorjev H2, brez prilagajanja odmerka.
English: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthrosis in patients with haemophilia type A and B treated with PIs.
Slovenian: Pri bolnikih s hemofilijo tipa A in B, zdravljenih z zaviralci proteaz, so poročali o zvečanih krvavitvah, vključno s spontanimi kožnimi hematomi in hemartrozo.
English: The usual dose of Darunavir Krka is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) once daily.
Slovenian: Običajni odmerek zdravila Darunavir Krka je 800 mg (dve tableti zdravila Darunavir Krka po 400 mg ali ena tableta zdravila Darunavir Krka po 800 mg) enkrat na dan.
English: Concomitant use of sildenafil or tadalafil for the treatment of pulmonary arterial hypertension and darunavir coadministered with low dose ritonavir may increase plasma concentrations of sildenafil or tadalafil.
Slovenian: Pri sočasni uporabi sildenafila ali tadalafila (za zdravljenje pljučne arterijske hipertenzije) in darunavirja v kombinaciji z majhnim odmerkom ritonavirja lahko pride do zvišanja plazemskih koncentracij sildenafila ali tadalafila.
English: Twice daily dosing Weight
Slovenian: Odmerjanje dvakrat na dan Telesna masa
English: Once daily dosing Weight
Slovenian: Odmerjanje enkrat na dan Telesna masa
English: Darunavir Krka contains the active substance darunavir.
Slovenian: Zdravilo Darunavir Krka vsebuje učinkovino darunavir.
English: Darunavir co-administered with low dose ritonavir should not be used in combination with these medicines.
Slovenian: Darunavirja z majhnim odmerkom ritonavirja ne smete uporabljati v kombinaciji s temi zdravili.