FrancophonIA/ELRC3.0 huggingface dataset:
English: If you are not sure, talk to your doctor or pharmacist before taking this medicine.
Croatian: Ako niste sigurni, obratite se svom liječniku ili ljekarniku prije početka primjene ovog lijeka.
English: Caution is therefore advised, especially in patients with renal impairment, when these drugs are coadministered with metformin, as metformin plasma concentration may increase.
Croatian: Stoga se savjetuje oprez, osobito u bolesnika s oštećenjem bubrega, kad se ti lijekovi primjenjuju istodobno s metforminom, jer se koncentracija metformina u plazmi može povisiti.
English: INFORMATION IN BRAILLE Jentadueto
Croatian: 16. PODACI NA BRAILLEOVOM PISMU Jentadueto
English: If you experience any of the signs of illness mentioned above, stop taking Jentadueto and call your doctor right away.
Croatian: Ako imate neki od gore navedenih znakova bolesti, prekinite s primjenom Jentadueta te se odmah javite liječniku.
English: Pharmacotherapeutic group: Drugs used in diabetes, combinations of oral blood glucose lowering drugs, ATC code: A10BD11
Croatian: Farmakoterapijska skupina: Lijekovi koji se primjenjuju u dijabetesu, kombinacije oralnih lijekova za snižavanje glukoze u krvi, ATK oznaka: A10BD11
English: Metformin hydrochloride increases the transport capacity of all types of membrane glucose transporters (GLUTs) known to date.
Croatian: Metforminklorid povećava prijenosni kapacitet svih tipova membranskih prijenosnika glukoze (GLUT) koji su do danas poznati
English: • Disease which may cause tissue hypoxia (especially acute disease, or worsening of chronic disease) such as: decompensated heart failure, respiratory failure, recent myocardial infarction,
Croatian: • Bolest koja može uzrokovati hipoksiju tkiva (naročito akutna bolest ili pogoršanje kronične bolesti) poput: dekompenziranog srčanog zatajenja, respiratornog zatajenja, nedavnog infarkta miokarda, šoka.
English: The most effective method to remove lactate and metformin hydrochloride is haemodialysis.
Croatian: Najučinkovitija metoda uklanjanja laktata i metforminklorida je hemodijaliza.
English: Single dose study: after single doses of metformin hydrochloride 500 mg, paediatric patients have shown a similar pharmacokinetic profile to that observed in healthy adults.
Croatian: Ispitivanje jednokratne doze: nakon primanja jednokratnih doza metforminklorida 500 mg, pedijatrijski bolesnici su pokazali sličan farmakokinetički profil onom primijećenom u zdravih odraslih osoba.
English: A dose reduction of the sulphonylurea or insulin may be considered (see section 4.2).
Croatian: Može se razmotriti sniženje doze sulfonilureje ili inzulina (vidjeti dio 4.2).
English: 83% of patients were taking metformin in combination with insulin in this trial.
Croatian: 83% bolesnika u ovom ispitivanju uzimalo je metformin u kombinaciji s inzulinom.
English: Lactic acidosis is a medical emergency and must be treated in hospital.
Croatian: Laktacidoza je hitno medicinsko stanje i mora se liječiti u bolnici.
English: Linagliptin binds very effectively to DPP-4 in a reversible manner and thus leads to a sustained increase and a prolongation of active incretin levels.
Croatian: Linagliptin se veže vrlo učinkovito na DPP-4 na reverzibilan način, čime dolazi do održanog povećanja i produljenja vrijednosti aktivnih inkretina.
English: The unbound concentrations, which are usually less than 1% at the therapeutic dose of linagliptin, were increased 4-5-fold after co-administration with ritonavir.
Croatian: Koncentracije nevezanog lijeka, koje su obično niže od 1% pri terapijskoj dozi linagliptina, povećale su se 4-5 puta nakon istovremene primjene s ritonavirom.
English: Thus full efficacy of linagliptin in combination with strong P-gp inducers might not be achieved, particularly if these are administered long-term.
Croatian: Stoga se ne mora nužno postići potpuna djelotvornost linagliptina u kombinaciji sa snažnim P-gp induktorima, osobito pri njihovoj dugotrajnoj primjeni.
English: At the recommended metformin hydrochloride doses and dosing schedules, steady-state plasma concentrations are reached within 24 to 48 hours and are generally less than 1 microgram/ml.
Croatian: Pri preporučenim dozama metforminklorida i režimima doziranja koncentracije u plazmi pri stanju dinamičke ravnoteže se postiže u roku 24 do 48 sati i općenito iznose manje od 1 mikrogram/ml.
English: What Jentadueto contains
Croatian: Što Jentadueto sadrži
English: Hypoglycaemia has not been seen with metformin hydrochloride doses of up to 85 g, although lactic acidosis has occurred in such circumstances.
Croatian: Hipoglikemija nije uočena uz doze metforminklorida do 85 g, iako se u spomenutim okolnostima pojavila laktacidoza.
English: Therefore, caution is advised when Jentadueto is used in combination with a sulphonylurea and/or insulin.
Croatian: Stoga se savjetuje oprez kada se Jentadueto primjenjuje u kombinaciji sa sulfonilurejom i/ili inzulinom.
English: Do not use this medicine after the expiry date which is stated on the blister, bottle and carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na blisteru, boci i kutiji iza oznake „EXP“.
English: The study included 3494 patients treated with linagliptin (5 mg) and 3485 patients treated with placebo.
Croatian: Ispitivanje je uključilo 3494 bolesnika liječena linagliptinom (5 mg) te 3485 bolesnika koji su primali placebo.
English: Monitoring of renal function is necessary to aid in prevention of metformin-associated lactic acidosis, particularly in the elderly (see sections 4.3 and 4.4).
Croatian: Praćenje funkcije bubrega je nužno kako bi se pomoglo u prevenciji laktacidoze povezane s metforminom, naročito u starijih bolesnika (vidjeti dijelove 4.3 i 4.4).
English: You should continue your diet during treatment with Jentadueto and take care that your carbohydrate intake is equally distributed over the day.
Croatian: Potrebno je nastaviti svoju dijetu tijekom liječenja Jentaduetom i pobrinuti se da je Vaš unos ugljikohidrata ravnomjerno raspoređen tijekom dana.
English: The use of linagliptin has not been studied in pregnant women.
Croatian: Primjena linagliptina nije ispitivana na trudnicama.
English: • in combination with other medicinal products for the treatment of diabetes, including insulin, in patients inadequately controlled with metformin and these medicinal products
Croatian: • u kombinaciji s drugim lijekovima za liječenje dijabetesa, uključujući inzulin, u bolesnika u kojih nije postignuta odgovarajuća kontrola pomoću metformina i tih lijekova
English: Lactic acidosis, a very rare but serious metabolic complication, most often occurs at acute worsening of renal function or cardiorespiratory illness or sepsis.
Croatian: Laktacidoza, vrlo rijetka, ali ozbiljna metabolička komplikacija, najčešće nastaje pri akutnom pogoršanju funkcije bubrega ili kardiorespiratornoj bolesti ili sepsi.
English: Food decreases the extent and slightly delays the absorption of metformin hydrochloride.
Croatian: Hrana smanjuje stupanj i neznatno odgađa apsorpciju metforminklorida.
English: This has been shown at therapeutic doses in controlled, medium-term or longterm clinical studies: metformin hydrochloride reduces total cholesterol, LDL cholesterol and triglyceride levels.
Croatian: To se pokazalo pri primjeni terapijskih doza u kontroliranim kliničkim ispitivanjima srednjeg ili dugog trajanja: metforminklorid smanjuje vrijednosti ukupnog kolesterola, LDL kolesterola i triglicerida.
English: Metformin is a substrate of both transporters OCT1 and OCT2.
Croatian: Metformin je supstrat i transportera OCT1 i transportera OCT2.
English: Dose reduction may be considered in relation to declining renal function.
Croatian: Može se razmotriti sniženje doze s obzirom na slabljenje funkcije bubrega.
English: Clinical experience with Jentadueto in patients with hepatic impairment is lacking.
Croatian: Nedostaje kliničko iskustvo s Jentaduetom u bolesnika s oštećenjem jetre.
English: Sulphonylureas and insulin are known to cause hypoglycaemia.
Croatian: Poznato je da sulfonilureje i inzulin izazivaju hipoglikemiju.
English: During controlled clinical trials in healthy subjects, single doses of up to 600 mg linagliptin (equivalent to 120 times the recommended dose) were not associated with a dose dependent increase in adverse events.
Croatian: Tijekom kontroliranih kliničkih ispitivanja u zdravih ispitanika, jednokratne doze do 600 mg linagliptina (što odgovara 120 puta većoj dozi od preporučene) nisu bile povezane s povećanjem štetnih događaja, koje je ovisno o dozi.
English: If necessary, the dose of the anti-hyperglycaemic medicinal product should be adjusted during therapy with the other medicinal product and on its discontinuation.
Croatian: Ako je nužno, doza antihiperglikemijskog lijeka mora se prilagoditi tijekom liječenja drugim lijekom ili nakon prekida njegovog uzimanja.
English: Your doctor may prescribe this medicine together with another oral anti-diabetic medicine or insulin.
Croatian: Liječnik Vam može propisati ovaj lijek u kombinaciji s drugim oralnim antidijabetikom ili inzulinom.
English: Clinically meaningful interactions would not be expected with other sulphonylureas (e.g., glipizide, tolbutamide, and glimepiride) which, like glibenclamide, are primarily eliminated by CYP2C9.
Croatian: Ne očekuju se klinički značajne interakcije s drugim sulfonilurejama (npr. glipizid, tolbutamid i glimepirid) koje se, poput glibenklamida, prvenstveno eliminiraju putem CYP2C9.
English: General Jentadueto should not be used in patients with type 1 diabetes.
Croatian: Općenito Jentadueto se ne smije primjenjivati kod bolesnika s dijabetesom tipa 1.
English: Administration of Jentadueto 2.5/1,000 mg with food resulted in no change in overall exposure of linagliptin.
Croatian: Primjena Jentadueta 2,5/1000 mg s hranom nije rezultirala promjenom u ukupnoj izloženosti linagliptinu.
English: Evaluation should include serum electrolytes and ketones, blood glucose and, if indicated, blood pH, lactate, pyruvate, and metformin levels.
Croatian: Ocjena mora uključivati elektrolite i ketone u serumu, glukozu u krvi i, ako je indicirano, pH i vrijednost laktata, piruvata i metformina u krvi.
English: Simulations of steady-state plasma concentrations of linagliptin with and without ritonavir indicated that the increase in exposure will not be associated with an increased accumulation.
Croatian: Simulacije koncentracija linagliptina u plazmi u stanju dinamičke ravnoteže, sa ili bez ritonavira, pokazale su da povećanje u izloženosti neće biti povezano s povećanom akumulacijom.
English: Plasma concentrations of linagliptin decline in a triphasic manner with a long terminal half-life (terminal half-life for linagliptin more than 100 hours), that is mostly related to the saturable, tight binding of linagliptin to DPP-4 and does not contribute to the accumulation of the active substance.
Croatian: Koncentracije linagliptina u plazmi padaju na trofazni način s dugim terminalnim poluvijekom (terminalni poluvijek linagliptina iznosi više od 100 sati), što je uglavnom povezano sa saturabilnim, čvrstim vezanjem linagliptina na DPP-4 te ne pridonosi akumulaciji djelatne tvari.
English: Diagnostic laboratory findings are decreased blood pH (<7.35), increased plasma lactate levels (>5 mmol/l) and an increased anion gap and lactate/pyruvate ratio.
Croatian: Dijagnostički laboratorijski nalazi pokazuju snižen pH krvi (<7,35), povišene razine laktata u plazmi (>5 mmol/l) i povećan anionski procjep te omjer laktata i piruvata.
English: Vitamin B12 deficiency very rare
Croatian: Manjak vitamina B12
English: It is assumed that the pharmacokinetics of metformin hydrochloride absorption are non-linear.
Croatian: Pretpostavlja se da farmakokinetika apsorpcije metformin hidrokorida nije linearna.
English: After oral administration, metformin hydrochloride absorption is saturable and incomplete.
Croatian: Nakon peroralne primjene apsorpcija metforminklorida je saturabilna i nepotpuna.
English: Approximately 19% of the population had eGFR ≥45 to <60 mL/min/1.73 m2, 28% of the population had eGFR ≥30 to <45 mL/min/1.73 m2) and 15%
Croatian: Približno 19% populacije imalo je eGFR≥ 45 do < 60 ml/min/1,73 m2, 28% populacije imalo je eGFR ≥ 30 do < 45 ml/min/1,73 m2, a 15% ih je imalo eGFR < 30 ml/min/1,73 m2.
English: Hypoglycaemia may occur when Jentadueto is administered together with sulphonylurea (≥ 1 case per 10 patients).
Croatian: Hipoglikemija se može pojaviti kada se Jentadueto primjenjuje zajedno sa sulfonilurejom (≥ 1 slučaj na 10 bolesnika).
English: Jentadueto may cause a very rare (may affect up to 1 user in 10,000), but very serious side effect called lactic acidosis (see section ‘Warnings and precautions').
Croatian: Jentadueto može uzrokovati vrlo rijetku (mogu se javiti u do 1 korisnika na 10 000), ali vrlo ozbiljnu nuspojavu koja se naziva laktacidoza (vidjeti dio “Upozorenja i mjere opreza”).
English: If you stop taking Jentadueto
Croatian: Ako prestanete uzimati Jentadueto
English: Jentadueto should not be used to treat this condition.
Croatian: Jentadueto se ne smije primjenjivati u liječenju ovog stanja.
English: Nervous system disorders Taste disturbance common
Croatian: Poremećaji živčanog sustava Poremećaj okusa često
English: Stop taking Jentadueto for a short time if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal.
Croatian: Prestanite nakratko uzimati Jentadueto ako imate stanje koje može biti povezano s dehidracijom (značajan gubitak tjelesnih tekućina) kao što je jako povraćanje, proljev, vrućica, izloženost toplini ili ako pijete manje tekućine nego obično.
English: If you have symptoms of acute pancreatitis, like persistent, severe abdominal pain, you should consult your doctor.
Croatian: Ako imate simptome akutne upale gušterače, poput stalne jake boli u trbuhu, morate se odmah obratiti Vašem liječniku.
English: Multiple daily doses of 5 mg linagliptin did not alter the pharmacokinetics of S(-) or R(+) warfarin, a CYP2C9 substrate, administered in a single dose.
Croatian: Višekratne dnevne doze 5 mg linagliptina nisu promijenile farmakokinetiku S(-) ili R(+) varfarina, supstrata izoenzima CYP2C9, koji je bio primijenjen u jednokratnoj dozi.
English: As metformin is excreted by the kidney, Jentadueto should be used with caution as age increases.
Croatian: S obzirom da se metformin izlučuje putem bubrega, Jentadueto se mora uzimati s oprezom kako se dob povećava.
English: Some symptoms need immediate medical attention You should stop taking Jentadueto and see your doctor straight away if you experience the following symptoms of low blood sugar (hypoglycaemia): trembling, sweating, anxiety, blurred vision, tingling lips, paleness, mood change, or confusion.
Croatian: Neki simptomi zahtijevaju hitnu medicinsku pomoć Morate prestati uzimati Jentadueto i odmah se javiti liječniku ako imate sljedeće simptome niskog šećera u krvi (hipoglikemija): drhtanje, znojenje, tjeskoba, zamućeni vid, trnci na usnicama, bljedilo, promjena raspoloženja, ili smetenost.
English: One main metabolite with a relative exposure of 13.3% of linagliptin at steady-state was detected which was found to be pharmacologically inactive, and thus does not contribute to the plasma DPP-4 inhibitory activity of linagliptin.
Croatian: Pronađen je jedan glavni metabolit s relativnom izloženosti od 13,3% linagliptina u stanju dinamičke ravnoteže za koji je otkriveno da je farmakološki neaktivan te stoga ne pridonosi DPP-4-inhibicijskoj aktivnosti linagliptina u plazmi.
English: In clinical studies, as described below, linagliptin had no clinically relevant effect on the pharmacokinetics of metformin, glyburide, simvastatin, warfarin, digoxin or oral contraceptives providing in vivo evidence of a low propensity for causing interactions with substrates of CYP3A4, CYP2C9, CYP2C8, P-glycoprotein, and organic cationic transporter (OCT).
Croatian: U kliničkim ispitivanjima, kako je opisano u nastavku, linagliptin nije imao klinički značajan učinak na farmakokinetiku metformina, gliburida, simvastatina, varfarina, digoksina ili oralnih kontraceptiva, što pruža in vivo dokaz za nisku sklonost uzrokovanju interakcija sa supstratima enzima CYP3A4, CYP2C9, CYP2C8, P-glikoproteina te transporterima organskih kationa (OCT).
English: Exposure in T2DM patients with severe RI was increased by about 1.4 fold compared to T2DM patients with normal renal function.
Croatian: Izloženost kod T2DM-bolesnika s teškim oštećenjem bubrega bila je povećana za oko 1,4 puta u usporedbi s T2DM-bolesnicima s normalnom funkcijom bubrega.
English: Difference from placebo (adjusted mean) (95% CI)
Croatian: Razlika od skupine na placebu (prilagođena srednja vrijednost) (95% CI)
English: Renal clearance of metformin hydrochloride is > 400 ml/min, indicating that metformin hydrochloride is eliminated by glomerular filtration and tubular secretion.
Croatian: Bubrežni klirens metforminklorida je > 400 ml/min što pokazuje da se metforminklorid eliminira putem glomerularne filtracije i tubularne sekrecije.
English: Race had no obvious effect on the plasma concentrations of linagliptin based on a composite analysis of available pharmacokinetic data, including patients of Caucasian, Hispanic, African, and Asian origin.
Croatian: Rasa nije imala primjetan učinak na koncentracije linagliptina u plazmi na osnovi kompozitne analize dostupnih farmakokinetičkih podataka, uključujući bolesnike bjelačkog, južnoameričkog, afričkog i azijskog porijekla.
English: There was no meaningful change from baseline in body weight in either group.
Croatian: Nije bilo značajnih promjena tjelesne težine u odnosu na početnu vrijednost u bilo kojoj od skupina.
English: However, taking Jentadueto in combination with medicines called sulphonylureas or with insulin can cause too low blood sugar level (hypoglycaemia), which may affect your ability to drive and use machines or work without safe foothold.
Croatian: Međutim, uzimanje Jentadueta u kombinaciji s lijekovima koji se nazivaju sulfonilureje ili s inzulinom može dovesti do pretjerano niskih vrijednosti šećera u krvi (hipoglikemija), što može utjecati na sposobnost upravljanja vozilima i strojevima i rad bez čvrstog uporišta.
English: Lactic acidosis is a medical emergency and must be treated in a hospital.
Croatian: Laktacidoza je hitno stanje i mora se liječiti u bolnici.
English: STOP taking Jentadueto and contact a doctor immediately if you notice any of the following serious side effects: - Severe and persistent pain in the abdomen (stomach area) which might reach through to your back, as well as nausea and vomiting, as it could be a sign of an inflamed pancreas
Croatian: PRESTANITE uzimati Jentadueto i odmah se obratite liječniku ako primijetite bilo koju od sljedećih ozbiljnih nuspojava: - Tešku i stalnu bol u abdomenu (područje trbuha), koja se može protezati skroz do leđa, te mučninu i povraćanje, jer to može biti znak upale gušterače (pankreatitis).
English: The intra-subject and inter-subject coefficients of variation for linagliptin AUC were small (12.6% and 28.5%, respectively).
Croatian: Koeficijenti varijacije u istog ispitanika i između ispitanika za AUC linagliptina bili su niski (12,6%, odnosno 28,5%).
English: However, patients should be alerted to the risk of hypoglycaemia when Jentadueto is used in combination with other antidiabetic medicinal products known to cause hypoglycaemia (e.g. sulphonylureas).
Croatian: Međutim, potrebno je upozoriti bolesnike na rizik od hipoglikemije kada se Jentadueto uzima u kombinaciji s drugim antidijabeticima za koje se zna da izazivaju hipoglikemiju (npr. sulfonilureje).
English: You should not use Jentadueto if you are pregnant.
Croatian: Jentadueto se ne smije primjenjivati ako ste trudni.
English: A paediatric Phase 2 study examined the pharmacokinetics and pharmacodynamics of 1 mg and 5 mg linagliptin in children and adolescents ≥10 to <18 years of age with type 2 diabetes mellitus.
Croatian: U pedijatrijskom ispitivanju faze 2 istražila se farmakokinetika i farmakodinamika 1 mg i 5 mg linagliptina u djece i adolescenata u dobi od ≥ 10 do < 18 godina sa šećernom bolešću tipa
English: In moderate renal impairment, a moderate increase in exposure of about 1.7 fold was observed compared with control.
Croatian: U umjerenom oštećenju bubrega primijećeno je umjereno povećanje u izloženosti od oko 1,7 puta u usporedbi s kontrolnom skupinom.
English: Linagliptin concentrations in this study were within the range of values previously observed in younger type 2 diabetes patients.
Croatian: Koncentracije linagliptina u ovom ispitivanju bile su unutar raspona prethodno primijećenih vrijednosti kod mlađih bolesnika s dijabetesom tipa 2.
English: The effect of Jentadueto on human fertility has not been studied.
Croatian: Nije ispitan učinak Jentadueta na plodnost u ljudi.
English: Therefore, clinically relevant interactions would not be expected with other P-glycoprotein/CYP3A4 inhibitors.
Croatian: Stoga se ne očekuju klinički značajne interakcije s drugim inhibitorima P-glikoproteina/CYP3A4.
English: General toxicity studies in rats for up to 13 weeks were performed with the co-administration of linagliptin and metformin.
Croatian: Ispitivanja opće toksičnosti u štakora u trajanju do 13 tjedana provedena su istovremenom primjenom linagliptina i metformina.
English: However, such studies have been conducted with the individual active substances, i.e. linagliptin and metformin.
Croatian: Međutim, takva ispitivanja su provedena s pojedinim djelatnim tvarima, tj. linagliptinom i metforminom.
English: The effective half-life for accumulation of linagliptin, as determined from oral administration of multiple doses of 5 mg linagliptin, is approximately 12 hours.
Croatian: Učinkoviti poluvijek za akumulaciju linagliptina, kao što je određeno iz oralne primjene višekratnih doza od 5 mg linagliptina iznosi približno 12 sati.
English: Patients with heart failure are more at risk of hypoxia and renal impairment.
Croatian: Bolesnici sa zatajenjem srca imaju veći rizik od hipoksije i oštećenja bubrega.
English: Skin and subcutaneous tissue disorders Angioedema rare
Croatian: Poremećaji kože i potkožnog tkiva Angioedem rijetko
English: If this happens to you, you may need immediate hospital treatment, as lactic acidosis can lead to coma.
Croatian: Ako Vam se to dogodi, potrebno Vam je hitno bolničko liječenje, jer laktacidoza može dovesti do kome.
English: Adults with normal renal function (GFR ≥90 ml/min) The dose of antihyperglycaemic therapy with Jentadueto should be individualised on the basis of the patient's current regimen, effectiveness, and tolerability, while not exceeding the maximum recommended daily dose of 5 mg linagliptin plus 2,000 mg of metformin hydrochloride.
Croatian: Odrasli s normalnom funkcijom bubrega (GFR≥ 90 ml/min) Dozu antihiperglikemijske terapije Jentaduetom potrebno je individualizirati na temelju bolesnikovog trenutnog režima, učinkovitosti i podnošljivosti, pri čemu se ne smije prekoračiti maksimalna preporučena dnevna doza od 5 mg linagliptina plus 2000 mg metforminklorida.
English: Linagliptin is a weak competitive and a weak to moderate mechanism-based inhibitor of CYP isozyme CYP3A4, but does not inhibit other CYP isozymes.
Croatian: Linagliptin je niskokompetetivan te slab do umjeren mehanizmom uvjetovan inhibitor CYP izoenzima CYP3A4, ali ne inhibira druge CYP-izoenzime.
English: After oral administration of a 5 mg dose to healthy volunteers or patients, linagliptin was rapidly absorbed, with peak plasma concentrations (median Tmax) occurring 1.5 hours post-dose.
Croatian: Nakon oralne primjene doze od 5 mg kod zdravih dobrovoljaca ili bolesnika, linagliptin se vrlo brzo apsorbirao, s pojavom vršnih koncentracija u plazmi (medijan Tmax) 1,5 sat nakon doziranja.
English: Furthermore GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepatic glucose output.
Croatian: Nadalje, GLP-1 također smanjuje sekreciju glukagona iz pankreatičnih alfa-stanica, rezultirajući smanjenjem proizvodnje glukoze u jetri.