FrancophonIA/ELRC3.0 huggingface dataset:
English: Because of the high safety margin (19-fold at this no-effect level), these neoplastic changes are not considered relevant for the situation in humans.
Croatian: Budući da su sigurnosne granice visoke (19 puta više od razine bez učinka), ove se neoplastičke promjene ne smatraju značajnima za situaciju u ljudi.
English: The safety and efficacy of sitagliptin in children and adolescents under 18 years of age have not yet been established.
Croatian: Sigurnost i djelotvornost sitagliptina u djece i adolescenata mlađih od 18 godina još nisu ustanovljene.
English: The fraction of sitagliptin reversibly bound to plasma proteins is low (38 %).
Croatian: Udio sitagliptina reverzibilno vezanog za proteine plazme je nizak (38%).
English: If you miss a dose, take it as soon as you remember.
Croatian: Propustite li uzeti dozu, uzmite je čim se sjetite.
English: If you have kidney problems, your doctor may prescribe lower doses (such as 25 mg or 50 mg).
Croatian: Ako imate tegobe s bubrezima, liječnik Vam može propisati niže doze (kao što su 25 mg ili 50 mg).
English: This can lead to serious medical problems like heart disease, kidney disease, blindness, and amputation.
Croatian: To može dovesti do ozbiljnih zdravstvenih tegoba kao što su bolest srca, bolest bubrega, sljepoća i amputacija.
English: This medicine is unlikely to cause low blood sugar because it does not work when your blood sugar is low.
Croatian: Nije vjerojatno da će ovaj lijek uzrokovati nizak šećer u krvi jer on ne djeluje kada je šećer u krvi nizak.
English: Because of the high safety margins, these findings do not suggest a relevant risk for human reproduction.
Croatian: Budući da je granica sigurnosti visoka, ovi nalazi ne upućuju na to da postoji značajan rizik za reprodukciju u ljudi.
English: If you take more Ristaben than you should If you take more than the prescribed dosage of this medicine, contact your doctor immediately.
Croatian: Ako uzmete više lijeka Ristaben nego što ste trebali Uzmete li veću dozu ovog lijeka od propisane, odmah se javite svom liječniku.
English: The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis.
Croatian: Inkretini su dio endogenog sustava koji sudjeluje u fiziološkoj regulaciji homeostaze glukoze.
English: What you need to know before you take Ristaben
Croatian: Što morate znati prije nego počnete uzimati lijek Ristaben
English: Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should.
Croatian: Šećerna bolest tip 2 je stanje u kojem Vaše tijelo ne proizvodi dovoljno inzulina, a inzulin koji Vaše tijelo proizvede ne djeluje kako bi trebao.
English: Continue to take this medicine as long as your doctor prescribes it so you can continue to help control your blood sugar.
Croatian: Nastavite uzimati ovaj lijek sve dok Vam ga liječnik propisuje kako biste šećer u krvi mogli i dalje držati pod kontrolom.
English: * Incidence rate per 100 patient-years is calculated as 100 × (total number of patients with ≥ 1 event during eligible exposure period per total patient-years of follow-up).
Croatian: * Stopa incidencije na 100 bolesnik-godina izračunava se kao 100 × (ukupan broj bolesnika koji imaju ≥ 1 događaja tijekom primjenjivog razdoblja izloženosti po ukupnom broju bolesnik-godina praćenja).
English: as monotherapy
Croatian: kao monoterapija
English: Your doctor may ask you to stop Ristaben.
Croatian: Vaš liječnik može zatražiti da prestanete s uzimanjem lijeka Ristaben.
English: These medical conditions can increase your chance of getting pancreatitis (see section 4).
Croatian: Ove zdravstvene tegobe mogu povećati vjerojatnost da dobijete pankreatitis (pogledajte dio 4.).
English: Because increases of this magnitude are not clinically relevant, dosage adjustment in these patients is not necessary.
Croatian: Budući da povećanja ovog reda nisu klinički značajna, u ovih bolesnika nije potrebna prilagodba doze.
English: However, when driving or using machines, it should be taken into account that dizziness and somnolence have been reported.
Croatian: Ipak, kod upravljanja vozilima ili rada sa strojevima treba uzeti u obzir da su pri primjeni ovoga lijeka prijavljene omaglica i somnolencija.
English: Sitagliptin is not a substrate for OCT2 or OAT1 or PEPT1/2 transporters.
Croatian: Sitagliptin nije supstrat transportera OCT2 ili OAT1 ili PEPT1/2.
English: The usual recommended dose is: one 100mg film-coated tablet once a day by mouth
Croatian: Uobičajena preporučena doza je: jedna filmom obložena tableta od 100mg jedanput na dan kroz usta
English: Both treatments were added to usual care targeting regional standards for HbA1c and CV risk factors.
Croatian: Obje su terapije bile dodatak standardnom liječenju usmjerenom na regionalne standardne vrijednosti HbA1c i faktore kardiovaskularnog (KV) rizika.
English: For all other endpoints, the p-values correspond to a test of differences in hazard rates.
Croatian: Za sve ostale mjere ishoda, p-vrijednosti odgovaraju ispitivanju razlika u omjerima hazarda.
English: Further, GLP-1 does not impair the normal glucagon response to hypoglycaemia.
Croatian: Nadalje, GLP-1 ne ometa normalan odgovor glukagona na hipoglikemiju.
English: The absolute bioavailability of sitagliptin is approximately 87 %.
Croatian: Apsolutna bioraspoloživost sitagliptina je približno 87%.
English: These reactions include anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome.
Croatian: Te reakcije uključuju anafilaksiju, angioedem i eksfolijativna stanja kože uključujući Stevens-Johnsonov sindrom.
English: Patients should be informed of the characteristic symptom of acute pancreatitis: persistent, severe abdominal pain.
Croatian: Bolesnike treba informirati o karakterističnom simptomu akutnog pankreatitisa: perzistentnoj jakoj boli u abdomenu.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 (see section 4.4 and 4.8).
Croatian: Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 6.1 (vidjeti dio 4.4 i 4.8).
English: Two studies were conducted to evaluate the efficacy and safety of sitagliptin monotherapy.
Croatian: Provedena su dva ispitivanja kako bi se utvrdila djelotvornost i sigurnost monoterapije sitagliptinom.
English: The level of digoxin in your blood may need to be checked if taking with Ristaben.
Croatian: Možda će biti potrebno provjeravati razinu digoksina u Vašoj krvi ukoliko se uzima s lijekom Ristaben.
English: Your doctor may prescribe this medicine alone or with certain other medicines that lower blood sugar.
Croatian: Liječnik Vam može propisati ovaj lijek sam ili s nekim drugim lijekovima za snižavanje šećera u krvi.
English: Resolution of pancreatitis has been observed after discontinuation of sitagliptin (with or without supportive treatment), but very rare cases of necrotising or haemorrhagic pancreatitis and/or death have been reported.
Croatian: Nakon obustave sitagliptina opaženo je povlačenje pankreatitisa (sa ili bez potpornog liječenja), no prijavljeni su vrlo rijetki slučajevi nekrotizirajućeg ili hemoragijskog pankreatitisa i/ili smrti.
English: For composite endpoints, the p-values correspond to a test of non-inferiority seeking to show that the hazard ratio is less than 1.3.
Croatian: Za objedinjene mjere ishoda, p-vrijednosti odgovaraju ispitivanju inferiornosti kojim se želi dokazati da je omjer hazarda manji od 1,3.
English: No dose adjustment is necessary based on gender, race, or body mass index (BMI).
Croatian: Nije potrebna prilagodba doze s obzirom na spol, rasu ili indeks tjelesne mase (ITM).
English: Other medicines and Ristaben
Croatian: Drugi lijekovi i Ristaben
English: Serious adverse reactions including pancreatitis and hypersensitivity reactions have been reported.
Croatian: Prijavljene su ozbiljne nuspojave uključujući pankreatitis i reakcije preosjetljivosti.
English: Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
Croatian: Stoga se ne očekuju značajne interakcije s drugim inhibitorima p-glikoproteina.
English: The mean dose of metformin was approximately 1,900 mg per day.
Croatian: Srednja vrijednost doze metformina bila je približno 1900 mg na dan.
English: p<0.001 compared to placebo or placebo + combination treatment.
Croatian: p < 0,001 u odnosu na placebo ili placebo + kombinaciju lijekova.
English: Dose-proportionality was not established for Cmax and C24hr (Cmax increased in a greater than dose-proportional manner and C24hr increased in a less than dose-proportional manner).
Croatian: Proporcionalnost dozi nije utvrđena za Cmax i C24h (povećanje Cmax je bilo veće, a C24h manje od povećanja proporcionalnog dozi).
English: - The active substance is sitagliptin.
Croatian: - Djelatna tvar je sitagliptin.
English: • Severe and persistent pain in the abdomen (stomach area) which might reach through to your back with or without nausea and vomiting, as these could be signs of an inflamed pancreas
Croatian: • jake bolove u abdomenu (području trbuha) koji ne prestaju i koji se mogu širiti u leđa, sa ili bez mučnine i povraćanja, jer bi to mogli biti znakovi upale gušterače (pankreatitisa).
English: Treatment by stratum (metformin and insulin use) interactions were not significant (p > 0.10).
Croatian: Interakcije istodobnog liječenja (metforminom i inzulinom) nisu bile značajne (p > 0,10).
English: Your doctor may reduce the dose of your sulphonylurea or insulin medicine.
Croatian: Vaš liječnik može smanjiti dozu sulfonilureje ili inzulina.
English: Sitagliptin is secreted in considerable amounts into the milk of lactating rats (milk/plasma ratio: 4:1).
Croatian: Sitagliptin se u znatnim količinama izlučuje u mlijeko štakorica u laktaciji (omjer mlijeko/plazma: 4:1).
English: If you have a serious allergic reaction (frequency not known), including rash, hives, blisters on the skin/peeling skin and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing, stop taking this medicine and call your doctor right away.
Croatian: Ako dobijete ozbiljnu alergijsku reakciju (učestalost nepoznata), uključujući osip, koprivnjaču, mjehuriće na koži/ljuštenje kože te oticanje lica, usnica, jezika i grla koje može uzrokovati otežano disanje ili gutanje, prestanite uzimati ovaj lijek i odmah se javite liječniku.
English: Your doctor may prescribe a medicine to treat your allergic reaction and a different medicine for your diabetes.
Croatian: Liječnik će Vam možda propisati lijek za liječenje alergijske reakcije i neki drugi lijek za liječenje šećerne bolesti.
English: Due to lack of human data, Ristaben should not be used during pregnancy.
Croatian: Zbog nedostatka podataka o primjeni u ljudi, Ristaben se ne smije uzimati tijekom trudnoće.
English: Packs of 14, 28, 30, 56, 84, 90 or 98 film-coated tablets and 50 x 1 film-coated tablets in perforated unit dose blisters.
Croatian: Pakiranja sa 14, 28, 30, 56, 84, 90 ili 98 filmom obloženih tableta i 50 x 1 filmom obloženom tabletom u perforiranim blisterima s jediničnim dozama.
English: However, patients at risk of digoxin toxicity should be monitored for this when sitagliptin and digoxin are administered concomitantly.
Croatian: Ipak, bolesnici s rizikom od toksičnosti digoksina moraju se pratiti kada se sitagliptin i digoksin primjenjuju istodobno.
English: If you encounter blistering of the skin it may be a sign for a condition called bullous pemphigoid.
Croatian: Ukoliko primjetite mjehuriće na koži, to može biti znak stanja koje se zove bulozni pemfigoid.
English: In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy if required.
Croatian: U slučaju predoziranja treba primijeniti uobičajene potporne mjere, npr. ukloniti neapsorbirani materijal iz gastrointestinalnog trakta, uvesti kliničko praćenje (uključujući i EKG) i po potrebi započeti potpornu terapiju.
English: Use of DPP-4 inhibitors has been associated with a risk of developing acute pancreatitis.
Croatian: Primjena inhibitora DPP-4 povezuje se s rizikom od razvoja akutnog pankreatitisa.
English: Number of patients
Croatian: Broj bolesnika
English: C]sitagliptin dose to healthy subjects, approximately 100 % of the administered radioactivity was eliminated in faeces (13 %) or urine (87 %) within one week of dosing.
Croatian: C]sitagliptina zdravim ispitanicima približno 100% primijenjene radioaktivnosti eliminiralo se stolicom (13%) ili mokraćom (87%) unutar jednog tjedna od doziranja.
English: p-value
Croatian: p-vrijednost.
English: The dose is 100 mg sitagliptin once daily.
Croatian: Doza je 100 mg sitagliptina jedanput na dan.
English: What Ristaben is and what it is used for What you need to know before you take Ristaben How to take Ristaben
Croatian: Što je Ristaben i za što se koristi Što morate znati prije nego počnete uzimati lijek Ristaben Kako uzimati lijek Ristaben
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP
English: What Ristaben contains
Croatian: Što Ristaben sadrži
English: Very common (may affect more than 1 in 10 people): low blood sugar Common: constipation
Croatian: Vrlo često (mogu se javiti u više od 1 na 10 osoba): nizak šećer u krvi Često: zatvor.
English: There are no adequate data from the use of sitagliptin in pregnant women.
Croatian: Nema odgovarajućih podataka o primjeni sitagliptina u trudnica.
English: Sitagliptin, but not metformin, increased active GIP concentrations.
Croatian: Sitagliptin je, ali ne i metformin, povisio koncentracije aktivnog GIP-a.
English: Hypoglycaemia has been reported in combination with sulphonylurea (4.7 %-13.8 %) and insulin (9.6 %) (see section 4.4).
Croatian: Hipoglikemija je prijavljena kod primjene u kombinaciji sa sulfonilurejom (4,7%-13,8%) i inzulinom (9,6%) (vidjeti dio 4.4).
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Ristaben in one or more subsets of the paediatric population in type 2 diabetes mellitus (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Ristaben u jednoj ili više podskupina pedijatrijske populacije za dijabetes mellitus tipa 2 (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: The difference was mainly due to a higher percentage of patients in the placebo group experiencing 3 or more episodes of hypoglycaemia (9.4 vs. 19.1 %).
Croatian: Ta je razlika nastala uglavnom zbog većeg postotka bolesnika u skupini koja je primala placebo koji su imali 3 ili više epizoda hipoglikemije (9,4 naspram 19,1%).
English: These changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful.
Croatian: Ove promjene u farmakokinetici sitagliptina nisu se smatrale klinički značajnima.
English: The improvement in glycaemic control observed with this medicinal product may be mediated by enhancing the levels of active incretin hormones.
Croatian: Poboljšana regulacija glikemije opažena s ovim lijekom vjerojatno je posredovana povišenjem razina aktivnih inkretinskih hormona.
English: If you stop taking Ristaben
Croatian: Ako prestanete uzimati lijek Ristaben
English: - an allergic reaction to Ristaben (see section 4).
Croatian: - Alergijsku reakciju na lijek Ristaben (pogledajte dio 4).
English: Baseline HbA1c was 8.74 % and baseline insulin dose was 37 IU/day.
Croatian: Početna vrijednost HbA1c bila je 8,74%, a početna doza inzulina 37 IU/dan.
English: TECOS Cardiovascular Safety Study
Croatian: Ispitivanje kardiovaskularne sigurnosti TECOS
English: Six metabolites were detected at trace levels and are not expected to contribute to the plasma DPP-4 inhibitory activity of sitagliptin.
Croatian: Otkriveno je šest metabolita u tragovima i ne očekuje se da oni pridonose inhibicijskoj aktivnosti sitagliptina u plazmi na DPP-4.
English: Taking this medicine in combination with medicines called sulphonylureas or with insulin can cause hypoglycaemia, which may affect your ability to drive and use machines or work without safe foothold.
Croatian: Uzimanje ovog lijeka u kombinaciji s lijekovima koji se zovu sulfonilureje ili s inzulinom može uzrokovati hipoglikemiju, koja može utjecati na sposobnost upravljanja vozilima i rada sa strojevima ili rada bez sigurnog oslonca.
English: * All Patients Treated Population (an intention-to-treat analysis).
Croatian: * Populacija svih liječenih bolesnika (analiza po planiranom planu ispitivanja, engl. intention-to-treat analysis).
English: In vitro, sitagliptin did not inhibit OAT3 (IC50=160 M) or p-glycoprotein (up to 250 M) mediated transport at therapeutically relevant plasma concentrations.
Croatian: In vitro sitagliptin nije inhibirao transport posredovan OAT3 (IC50=160 µM) ili p-glikoproteinom (do 250 µM) pri terapijski značajnim koncentracijama u plazmi.
English: After a median follow up of 3 years, sitagliptin, when added to usual care, did not increase the risk of major adverse cardiovascular events or the risk of hospitalization for heart failure compared to usual care without sitagliptin in patients with type 2 diabetes (Table 3).
Croatian: Nakon medijana praćenja od 3 godine, sitagliptin kao dodatak standardnom liječenju nije povećao rizik od značajnih štetnih kardiovaskularnih događaja niti rizik od hospitalizacije zbog zatajenja srca u bolesnika s dijabetesom tipa 2 u usporedbi sa standardnim liječenjem bez sitagliptina (Tablica 3).
English: There is no clinical experience in patients with severe hepatic impairment (Child-Pugh score > 9).
Croatian: Nema kliničkog iskustva u bolesnika s teškim oštećenjem funkcije jetre (Child-Pugh rezultat > 9).
English: Your doctor has prescribed this medicine to help lower your blood sugar, which is too high because of your type 2 diabetes.
Croatian: Liječnik Vam je propisao ovaj lijek da pomogne sniziti Vaš šećer u krvi, koji je previsok zbog šećerne bolesti tipa
English: No dose adjustment is required based on age.
Croatian: Nije potrebna prilagodba doze s obzirom na dob.
English: For this reason, it is possible that potent CYP3A4 inhibitors (i.e. ketoconazole, itraconazole, ritonavir, clarithromycin) could alter the pharmacokinetics of sitagliptin in patients with severe renal impairment or ESRD.
Croatian: Iz tog razloga je moguće da potentni inhibitori CYP3A4 (tj. ketokonazol, itrakonazol, ritonavir, klaritromicin) mogu promijeniti farmakokinetiku sitagliptina u bolesnika s teškim oštećenjem funkcije bubrega ili završnom fazom bubrežne bolesti.
English: • in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance.
Croatian: • u bolesnika neodgovarajuće kontroliranih samo dijetom i tjelovježbom i u kojih metformin nije prikladan za liječenje zbog kontraindikacija ili nepodnošljivosti.
English: Other patient characteristics
Croatian: Druge osobitosti bolesnika
English: OAT3 mediated transport of sitagliptin was inhibited in vitro by probenecid, although the risk of clinically meaningful interactions is considered to be low.
Croatian: Probenecid je inhibirao transport sitagliptina posredovan OAT3 in vitro, premda se rizik od klinički značajnih interakcija smatra niskim.
English: In vitro data showed that sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4 and CYP1A2.
Croatian: In vitro podaci pokazali su da sitagliptin nije inhibitor CYP izoenzima CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 ili 2B6 te da nije induktor CYP3A4 i CYP1A2.
English: The overall incidence of gastrointestinal adverse reactions considered as drug-related in patients treated with sitagliptin was 2.7 % compared with 12.6 % in patients treated with metformin.
Croatian: Ukupna incidencija gastrointestinalnih nuspojava za koje se smatralo da su povezane s lijekom bila je 2,7% u bolesnika liječenih sitagliptinom u odnosu na 12,6% u bolesnika liječenih metforminom.
English: C]sitagliptin oral dose, approximately 16 % of the radioactivity was excreted as metabolites of sitagliptin.
Croatian: C]sitagliptina približno 16% radioaktivnosti izluči se u obliku metabolita sitagliptina.
English: Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin.
Croatian: Sitagliptin je supstrat humanog organskog anionskog transportera-3 (hOAT-3) koji bi mogao biti uključen u eliminaciju sitagliptina putem bubrega.
English: If you forget to take Ristaben
Croatian: Ako ste zaboravili uzeti lijek Ristaben
English: The apparent terminal t1/2 following a 100-mg oral dose of sitagliptin was approximately 12.4 hours.
Croatian: Prividni terminalni t1/2 sitagliptina nakon peroralne doze od 100 mg bio je približno 12,4 sata.
English: A no-effect level for these findings was found at an exposure 6-fold the clinical exposure level.
Croatian: Razina bez učinka za ove nalaze bila je pri razini izloženosti 6 puta većoj od razina kliničke izloženosti.
English: BLISTERS
Croatian: BLISTERI
English: Overall, sitagliptin improved glycaemic control when used as monotherapy or in combination treatment (see Table 2).
Croatian: Ukupno gledajući, sitagliptin je poboljšao regulaciju glikemije kada se uzimao kao monoterapija ili u kombiniranom liječenju (vidjeti Tablicu 2).
English: If pancreatitis is suspected, Ristaben and other potentially suspect medicinal products should be discontinued; if acute pancreatitis is confirmed, Ristaben should not be restarted.
Croatian: Posumnja li se na pankreatitis, mora se prekinuti primjena lijeka Ristaben i drugih lijekova za koje se sumnja da bi ga mogli izazvati; potvrdi li se akutni pankreatitis, liječenje lijekom Ristaben ne smije se ponovno započeti.
English: Tel. +48 22 721 40 00 bioinfo@bioton.pl
Croatian: +48 22 721 40 00 bioinfo@bioton.pl
English: These included hypoglycaemia (frequency very common with the combination of sulphonylurea and metformin), influenza (common with insulin (with or without metformin)), nausea and vomiting (common with metformin), flatulence (common with metformin or pioglitazone), constipation (common with the combination of sulphonylurea and metformin), peripheral oedema (common with pioglitazone or the combination of pioglitazone and metformin), somnolence and diarrhoea (uncommon with metformin), and dry mouth (uncommon with insulin (with or without metformin)).
Croatian: To je uključivalo hipoglikemiju (učestalost vrlo česta s kombinacijom sulfonilureje i metformina), influencu (česta s inzulinom (sa ili bez metformina)), mučnina i povraćanje (česta s metforminom), flatulencija (česta s metforminom ili pioglitazonom), konstipacija (česta s kombinacijom sulfonilereje i metformina), periferni edem (česta s pioglitazonom ili kombinacijom pioglitazona i metformina), somnolencija i dijareja (manje česta s metforminom) i suha usta (manje česta s inzulinom (sa ili bez metformina)).
English: The effect of potent CYP3A4 inhibitors in the setting of renal impairment has not been assessed in a clinical study.
Croatian: Učinci potentnih inhibitora CYP3A4 u bolesnika s oštećenjem funkcije bubrega nisu procijenjeni u kliničkom ispitivanju.
English: as dual oral therapy in combination with
Croatian: kao dvojna peroralna terapija, u kombinaciji
English: Immune system disorders hypersensitivity reactions including anaphylactic responses
Croatian: Poremećaji imunološkog sustava reakcije preosjetljivosti uključujući anafilaktičke odgovore nepoznata učestalost
English: You should not take this medicine if you are breast-feeding or plan to breast-feed.
Croatian: Ne smijete uzimati ovaj lijek ako dojite ili planirate dojiti.
English: Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion.
Croatian: Eliminacija sitagliptina se primarno odvija izlučivanjem putem bubrega i uključuje aktivnu tubularnu sekreciju.