FrancophonIA/ELRC3.0 huggingface dataset:
English: Because of known increased risks of bleeding in conjunction with the use of imatinib (e.g. haemorrhage), patients who require anticoagulation should receive low-molecular-weight or standard heparin instead of coumarin derivatives such as warfarin.
Danish: På grund af kendt øget risiko for blødning i forbindelse med brug af imitanib (f.eks. hæmoragi) bør patienter med behov for antikoagulantia have heparin med lav molekylevægt eller standardheparin i stedet for coumarinderivater som warfarin.
English: Very common
Danish: Meget almindelig:
English: In an oral pre- and postnatal development study in rats, red vaginal discharge was noted in the 45 mg/kg/day group on either day 14 or day 15 of gestation.
Danish: I et oralt præ- og postnatalt udviklingsstudie med rotter sås rødt, vaginalt udflåd i gruppen med 45 mg/kg/dag på enten dag 14 eller dag 15 efter gestation.
English: One blister contains 10 capsules.
Danish: En blister indeholder 10 kapsler.
English: The effect of imatinib on the outcome of bone marrow transplantation has not been determined.
Danish: Imatinibs effekt på resultatet af knoglemarvstransplantation er ikke blevet bestemt.
English: Therapy should be initiated by a physician experienced in the treatment of patients with haematological malignancies and malignant sarcomas, as appropriate.
Danish: Behandlingen bør initieres af en læge med erfaring i behandling af patienter med maligne hæmatologiske lidelser og maligne sarkomer eller som passende.
English: If laboratory or clinical findings associated with TMA occur in a patient receiving Imatinib Actavis, treatment should be discontinued and thorough evaluation for TMA, including ADAMTS13 activity and antiADAMTS13-antibody determination, should be completed.
Danish: Hvis laboratorie- eller kliniske fund associeret med TMA forekommer hos en patient, som er i behandling med Imatinib Actavis, skal behandlingen seponeres og der skal foretages en grundig undersøgelse for TMA, inklusiv ADAMTS13aktivitet og anti-ADAMTS13-antistofbestemmelse.
English: Unchanged imatinib accounted for 25% of the dose (5% urine, 20% faeces), the remainder being metabolites.
Danish: Uomdannet imatinib er ansvarlig for ca. 25 % af dosis (5 % urin og 20 % fæces), resten er metabolitter.
English: - This medicine has been prescribed for you only.
Danish: - Lægen har ordineret lægemidlet til dig personligt.
English: There have been post-marketing reports of spontaneous abortions and infant congenital anomalies from women who have taken imatinib.
Danish: Der har efter markedsføring været rapporter om spontane aborter og medfødte abnormaliteter hos spædbørn født af kvinder, som har taget imatinib.
English: The safety database for children with Ph+ALL is very limited though no new safety concerns have been identified.
Danish: Sikkerhedsdatabasen for børn med Ph+ ALL er meget begrænset.
English: In patients with hypereosinophilic syndrome (HES) with occult infiltration of HES cells within the myocardium, isolated cases of cardiogenic shock/left ventricular dysfunction have been associated with HES cell degranulation upon the initiation of imatinib therapy.
Danish: Hos patienter med hypereosinofilt syndrom (HES) med skjult infiltration af HES celler i myokardiet, har der været isolerede tilfælde af carcinogent chok/dysfunktion af venstre ventrikel forbundet med HES celledegranulering ved initiering af imatinibterapi.
English: Treatment of CML patients with imatinib has been associated with neutropenia or thrombocytopenia.
Danish: Behandling af CMLpatienter med imatinib har været associeret med neutropeni eller trombocytopeni.
English: The required number of tablets should be placed in the appropriate volume of beverage (approximately 50 ml for a 100 mg tablet, and 200 ml for a 400 mg tablet) and stirred with a spoon.
Danish: Det nødvendige antal tabletter skal placeres i en drik af passende volumen (ca. 50 ml til en 100 mg tablet og 200 ml til en 400 mg tablet) og omrøres med en ske.
English: Constitutive activation of the PDGF receptor or the Abl protein tyrosine kinases as a consequence of fusion to diverse partner proteins or constitutive production of PDGF have been implicated in the pathogenesis of MDS/MPD, HES/CEL and DFSP.
Danish: Vedvarende aktivering af PDGF receptoren eller Abl protein tyrosinkinase, der opstår på grund af en fusion med andre proteiner eller konstitutiv produktion af PDGF er blevet impliceret i patogenesen af MDS/MPD, HES/CEL og DFSP.
English: Isolated cases of imatinib overdose have been reported spontaneously and in the literature.
Danish: Enkelte tilfælde af overdosering med imatinib er blevet spontant rapporteret i literaturen.
English: MDS/MPD (starting dose 400 mg)
Danish: MDS/MPD (startdosis 400 mg)
English: Imatinib Actavis is a medicine containing an active substance called imatinib.
Danish: Imatinib Actavis er et lægemiddel, der indeholder et aktivt stof kaldet imatinib.
English: Not known (frequency cannot be estimated from the available data): - Reddening and/or swelling on the palms of the hands and soles of the feet which may be accompanied by tingling sensation and burning pain.
Danish: Ikke kendt (hyppigheden kan ikke vurderes ud fra tilgængelige data): - Rødmen og/eller hævelse af håndflader eller fodsåler, hvilket kan være ledsaget af en prikkende følelse eller brændende smerte.
English: Some medicines can interfere with the effect of Imatinib Actavis when taken together.
Danish: Nogle lægemidler kan påvirke virkningen af Imatinib Actavis, når de bruges samtidigt.
English: Ara-C: cytosine arabinoside; CP: cyclophosphamide; DEX: dexamethasone; MTX: methotrexate; 6-MP: 6-mercaptopurine; VM26: Teniposide; VCR: vincristine; IDA: idarubicine; i.v.
Danish: Ara-C: cytosin arabinosid; CP: cyclophosphamid; DEX: dexamethason; MTX: methotrexat; 6-MP: 6-mercaptopurin; VM26: teniposid; VCR: vinkristin; IDA: idarubicin; i.v.
English: In CML, cytopenias, particularly neutropenia and thrombocytopenia, have been a consistent finding in all studies, with the suggestion of a higher frequency at high doses ≥ 750 mg (phase I study).
Danish: Cytopeni hos CML-patienter, særligt neutropeni og trombocytopeni, har været gennemgående fund i alle undersøgelser med tegn på større hyppighed ved doser ≥ 750 mg (fase I undersøgelse).
English: - Unexpected bleeding or bruising (when you have not hurt yourself).
Danish: - Hvis du oplever uventede blødninger eller blå mærker (når du ikke er kommet til skade).
English: - If you are being treated for CML:
Danish: - Hvis du er i behandling for CML:
English: Resume treatment with imatinib at 600 mg.
Danish: Genoptag behandlingen med imatinib 600 mg.
English: This was not seen at doses ≤ 20 mg/kg.
Danish: Dette sås ikke ved doser ≤20 mg/kg.
English: In the F1 offspring, at the same dose level, mean body weights were reduced from birth until terminal sacrifice and the number of litters achieving criterion for preputial separation was slightly decreased.
Danish: I F1-afkommet var den gennemsnitlige kropsvægt ved samme dosisniveau reduceret fra fødsel til aflivning og antallet af kuld der opfyldte kriteriet for præputial separation var let nedsat.
English: In the juvenile toxicology study, effects upon growth, delay in vaginal opening and preputial separation were observed at approximately 0.3 to 2 times the average paediatric exposure at the highest recommended dose of 340 mg/m2.
Danish: I det juvenile toksikologistudie blev der set effekt på vækst samt forsinket vaginalåbning og præputial separation ved ca. 0,3 til 2 gange den gennemsnitlige pædiatriske eksponering ved den højst anbefalede dosis på 340 mg/m2.
English: - Dermatofibrosarcoma protuberans (DFSP).
Danish: - Dermatofibrosarkom protuberans (DFSP).
English: Acute respiratory failure11*, interstitial lung disease*
Danish: Akut respirationssvigt11*, interstitiel lungesygdom*
English: The adult patients reported in the published literature were treated with either 400 mg (4 cases) or 800 mg (1 case) imatinib daily.
Danish: De voksne patienter, som er beskrevet i publiceret litteratur blev behandlet med enten 400 mg (fire tilfælde) eller 800 mg (et tilfælde) imatinib daglig.
English: In vitro imatinib inhibits the cytochrome P450 isoenzyme CYP2D6 activity at concentrations similar to those that affect CYP3A4 activity.
Danish: In vitro hæmmer imatinib cytochrom P450 isoenzym CYP2D6-aktivitet ved koncentrationer svarende til dem, der påvirker CYP3A4-aktivitet.
English: Table 1 Tabulated summary of adverse reactions Infections and infestations
Danish: Tabel 1 Opsummering af bivirkninger i kliniske studier Infektioner og parasitære sygdomme
English: However, always take this medicine exactly as your doctor or pharmacist has told you.
Danish: Tag altid dette lægemiddel nøjagtigt efter lægens eller apotekspersonalets anvisning.
English: Study 0102 38-month data Myeloid blast crisis (n=260) % of patients (CI95%)
Danish: Undersøgelse 0102 38 måneders data Myeloid blastkrise (n=260)
English: Al/PVC/Aclar blister.
Danish: Aluminium/PVC/aclar blister.
English: 24 hard capsules 48 hard capsules 60 hard capsules 96 hard capsules 120 hard capsules 180 hard capsules
Danish: 24 hårde kapsler 48 hårde kapsler 60 hårde kapsler 96 hårde kapsler 120 hårde kapsler 180 hårde kapsler
English: These effects were not seen at doses ≤ 30 mg/kg.
Danish: Disse virkninger sås ikke ved doser ≤30 mg/kg.
English: Depression, libido decreased, anxiety
Danish: Depression, nedsat libido, angst
English: You may become more sensitive to the sun while taking Imatinib Actavis.
Danish: Du kan blive mere følsom overfor sollys, når du tager Imatinib Actavis.
English: Imatinib at 400 mg twice daily had an inhibitory effect on CYP2D6-mediated metoprolol metabolism, with metoprolol Cmax and AUC being increased by approximately 23% (90%CI [1.16-1.30]).
Danish: 400 mg imatinib to gange daglig havde en inhibitorisk effekt på CYP2D6-medieret metoprololmetabolisme, som gav en stigning af Cmax og AUC for metoprolol på cirka 23 % (90 %CI [1,16-1,30]).
English: If you have accidentally taken too many capsules, talk to your doctor straight away.
Danish: Hvis du ved et uheld har indtaget for mange kapsler, skal du kontakte din læge med det samme.
English: There is limited information on imatinib distribution on human milk.
Danish: Der er begrænset information om fordelingen af imatinib i modermælk.
English: Maximal plasma concentrations of imatinib in patients are 2-4 μmol/L, consequently an inhibition of CYP2D6 and/or CYP3A4/5-mediated metabolism of co-administered drugs is possible.
Danish: Maksimale plasmakoncentrationer af imatinib er hos patienter 2-4 μmol/l, og hæmning af CYP2D6 og/eller CYP3A4/5-medieret metabolisme af samtidigt administrerede lægemidler er derfor mulig.
English: Table 3 Chemotherapy regimen used in combination with imatinib Study ADE10
Danish: Tabel 3 Kemoterapiregime anvendt i kombination med imatinib Studie ADE10
English: Caution should be taken when administering imatinib with inhibitors of the CYP3A4 family.
Danish: Forsigtighed bør udvises, når imatinib administreres sammen med hæmmere af CYP3A4-familien.
English: All patients received imatinib and consolidation chemotherapy (see Table 3) after induction and the levels of bcr-abl transcripts were identical in the two arms at 8 weeks.
Danish: Alle patienter blev efter induktion behandlet med imatinib og standard kemoterapi (se Tabel 3), og bcr-abl transkriptionerne var identiske i de to arme efter 8 ugers behandling.
English: Alternating chemotherapy course: high dose chemotherapy with MTX 1 g/m2 i.v.
Danish: Supplerende kemoterapi omgange: høj-dosis kemoterapi med MTX 1 g/m2 i.v.
English: Grade 3 and 4 neutropenia was seen in 7.5% and 2.7% of patients, respectively, and grade 3 thrombocytopenia in 0.7% of patients.
Danish: Grad 3 og 4 neutropeni sås hos henholdsvis 7,5 % og 2,7 % af patienterne og grad 3 trombocytopeni hos 0,7 % af patienterne.
English: - Chronic myeloid leukaemia (CML).
Danish: - Kronisk myeloid leukæmi (CML).
English: (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000),
Danish: Frekvenskategorier er defineret ved brug af følgende konvention: Meget almindelig (≥1/10), almindelig (≥1/100 til <1/10), ikke almindelig (≥1/1.000 til <1/100), sjælden (≥1/10.000 til <1/1.000), meget sjælden
English: Imatinib inhibits signalling and proliferation of cells driven by dysregulated PDGFR and Abl kinase activity.
Danish: Imatinib hæmmer signalleringen og vækst af celler, der drives af dysreguleret PDGFR og Abl kinaseaktivitet.
English: The comparison of AUC(0-24) on day 8 and day 1 at the 340 mg/m2/day dose level revealed a 1.7-fold drug accumulation after repeated once-daily dosing.
Danish: Sammenligningen af AUC(0-24) på dag 8 og dag 1 ved 340 mg/m2/dag dosisniveauet viste en 1,7 gang højere lægemiddelakkumulering efter gentagen dosering, én gang daglig.
English: In GIST patients (study B2222), 6.8% of grade 3 or 4 ALT (alanine aminotransferase) elevations and 4.8% of grade 3 or 4 AST (aspartate aminotransferase) elevations were observed.
Danish: Der blev hos GIST patienter (studie B2222) observeret stigning i grad 3 eller 4 ALAT (alaninaminotransferase) hos 6,8 % og stigning i grad 3 eller 4 ASAT (aspartataminotransferase) hos 4,8 %.
English: If you have accidentally taken too many tablets, talk to your doctor straight away.
Danish: Hvis du ved et uheld har indtaget for mange tabletter, skal du kontakte din læge med det samme.
English: Therefore, concomitant use of strong CYP3A4 inducers and imatinib should be avoided (see section 4.5).
Danish: Samtidig anvendelse af stærke CYP3A4 induktorer og imatinib bør derfor undgås (se pkt.
English: Imatinib Actavis is also a treatment for adults for: - Myelodysplastic/myeloproliferative diseases (MDS/MPD).
Danish: Imatinib Actavis anvendes også til behandling af voksne med: - Myelodysplastiske/myeloproliferative sygdomme (MDS/MDP).
English: At the time of analysis, the treatment duration was a median of 47 months (24 days - 60 months).
Danish: På opgørelsestidspunktet var medianen for behandlingstiden 47 måneder (24 dage - 60 måneder).
English: Imatinib was administered intermittently in cohorts 1-5, with increasing duration and earlier start of imatinib from cohort to cohort; cohort 1 receiving the lowest intensitiy and cohort 5 receiving the highest intensity of imatinib (longest duration in days with continuous daily imatinib dosing during the first chemotherapy treatment courses).
Danish: Imatinib blev administreret periodisk i kohorte 1-5 med stigende varighed og tidligere start med imatinib fra kohorte til kohorte; kohorte 1 fik den mindst intensive imatinib-behandling og kohorte 5 den mest intensive (længste varighed i dage med kontinuerlig, daglig imatinib-dosering i de første kemobehandlingsforløb).
English: Dose increase from 100 mg to 400 mg may be considered in the absence of adverse drug reactions if assessments demonstrate an insufficient response to therapy.
Danish: Dosisøgning fra 100 mg til 400 mg kan overvejes, hvis der ikke er observeret bivirkninger, og respons på behandlingen vurderes som værende utilstrækkeligt.
English: BCR-ABL tyrosine kinase inhibitors (TKIs) have been associated with thrombotic microangiopathy (TMA), including individual case reports for Imatinib Actavis (see section 4.8).
Danish: BCR-ABL-tyrosinkinasehæmmere (TKI'er) er blevet associeret med trombotisk mikroangiopati (TMA), herunder enkeltstående rapporter for Imatinib Actavis (se pkt.
English: Not known (frequency cannot be estimated from the available data): - Combination of a widespread severe rash, feeling sick, fever, high level of certain white blood cells or yellow skin or eyes (signs of jaundice) with breathlessness, chest pain/discomfort, severely decreased urine output and feeling thirsty etc. (signs of a treatment-related allergic reaction).
Danish: Ikke kendt (kan ikke vurderes ud fra tilgængelige data): - Kombination af omfattende svært udslæt, følelse af at være syg, feber, højt indhold af visse hvide blodlegemer eller gul hud eller øjne (tegn på gulsot) med stakåndethed, brystsmerter/ubehag, svært nedsat urinproduktion og tørst osv. (tegn på en behandlingsrelateret allergisk reaktion).
English: Do not take Imatinib Actavis:
Danish: Tag ikke Imatinib Actavis:
English: Imatinib Actavis is indicated for - the treatment of adult patients with unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery.
Danish: Imatinib Actavis er indiceret til - behandling af voksne patienter med inoperabel dermatofibrosarkom protuberans (DFSP) og voksne patienter med residiverende og/eller metastaserende DFSP som ikke er tilgængelig for kirurgi.
English: - Recurrence (reactivation) of Hepatitis B infection when you have had hepatitis B in the past (a liver infection).
Danish: - Genopblussen (reaktivering) af hepatitis B-infektion, hvis du tidligere har haft hepatitis B (leverbetændelse type B).
English: In eleven patients PDGFR gene rearrangements was detected, 9 of them achieved a CHR and 1 PHR.
Danish: Der blev set PDGFRomlejring hos 11 patienter, 9 af disse opnåede CHR og 1 PHR.
English: Imatinib was teratogenic in rats when administered during organogenesis at doses ≥ 100 mg/kg,
Danish: Imatinib var teratogent hos rotter ved administration under organgenese ved doser ≥100 mg/kg, ca.
English: Imatinib is a protein-tyrosine kinase inhibitor which potently inhibits the Bcr-Abl tyrosine kinase at the in vitro, cellular and in vivo levels.
Danish: Imatinib er en protein-tyrosinkinasehæmmer, som potent hæmmer Bcr-Abl tyrosinkinasen in vitro, in vivo og på cellulært niveau.
English: The 23 patients enrolled in this registry received imatinib at a median daily dose of 264 mg (range: 100 to 400 mg) for a median duration of 7.2 years (range 0.1 to 12.7 years).
Danish: De 23 patienter som var inkluderet i registerstudiet, fik imatinib med en daglig mediandosis på 264 mg (dosisområde: 100 til 400 mg) med en median varighed på 7,2 år (behandlingstid 0,1 til 12,7 år).
English: - Feeling dizzy or weak.
Danish: - Føle sig svimmel eller svag.
English: 6-MP (75 mg/m2/day, PO): days 11-56 (Withhold 6-MP during the 6-10 days of cranial irradiation beginning on day 1 of Cycle 5.
Danish: 6-MP (75 mg/m2/dag, p.o.): dag 11-56 (tilbagehold 6-MP i de 6-10 dage med kraniebestråling med start dag 1 i cyklus 5.
English: Pretreatment with multiple doses of rifampicin 600 mg followed by a single 400 mg dose of imatinib resulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment.
Danish: Præbehandling med gentagne doser af rifampicin 600 mg efterfulgt af enkeltdosis imatinib 400 mg resulterede i fald i imatinib resulted in decrease in Cmax og AUC(0-∞) på mindst 54 % og 74 % af værdierne uden rifampicinbehandling.
English: Metabolism of imatinib is mainly hepatic, and only 13% of excretion is through the kidneys.
Danish: Imatinib metaboliseres primært i leveren, og kun 13 % udskilles via nyrerne.
English: A total of 51 paediatric patients with newly diagnosed and untreated CML in chronic phase have been enrolled in an open-label, multicentre, single-arm phase II trial.
Danish: I alt 51 børn med nydiagnosticeret og ubehandlet CML i kronisk fase blev inkluderet i en åben, multicenter, enkeltarm fase II undersøgelse.
English: Patients with mild, moderate or severe liver dysfunction should be given the minimum recommended dose of 400 mg daily.
Danish: Patienter med mild, moderat eller svær nedsat leverfunktion bør gives den mindste anbefalede dosis på 400 mg daglig.
English: Imatinib Actavis contains lecithin (soya)
Danish: Imatinib Actavis indeholder lecithin (soya)
English: - Then continue with your normal schedule.
Danish: - Fortsæt derefter med den planlagte dosering.
English: There is very limited experience in children with MDS/MPD, DFSP, and HES/CEL.
Danish: Der er meget begrænset erfaring hos børn med MDS/MPD, DFSP, og HES/CEL.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTERS
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP BLISTERPAKNINGER
English: Miscellaneous adverse reactions such as pleural effusion, ascites, pulmonary oedema and rapid weight gain with or without superficial oedema may be collectively described as “fluid retention”.
Danish: Diverse bivirkninger, som for eksempel pleuraeksudat, ascites, lungeødem og hurtig vægtstigning med eller uden overfladiske ødemer, kan kollektivt betegnes som ”væskeretention”.
English: However, the occurrence of cytopenias was also clearly dependent on the stage of the disease, the frequency of grade 3 or 4 neutropenias (ANC < 1.0 x 109/L) and thrombocytopenias (platelet count < 50 x 109/L) being between 4 and 6 times higher in blast crisis and accelerated phase (59-64% and 44-63% for neutropenia and thrombocytopenia, respectively) as compared to newly diagnosed patients in chronic phase CML (16.7% neutropenia and 8.9% thrombocytopenia).
Danish: Incidensen af cytopeni hang imidlertid også tydeligt sammen med sygdomsstadiet, idet hyppighed af 3. eller 4. grads neutropeni (ANC <1,0 x 109/l) og thrombocytopenias (platelet count < 50 x 109/l) var 4-6 gange højere ved blastkrise og accelereret fase (59-64 % og 44-63 % for henholdsvis neutropeni og trombopeni) end ved sammenligning med nydiagnosticerede patienter med kronisk fase CML (16,7 % neutropeni og 8,9 % trombocytopeni).
English: Palmoplantar erythrodysesthesia syndrome*, lichenoid keratosis*, lichen planus*, toxic epidermal necrolysis*, drug rash with eosinophilia and systemic symptoms (DRESS)*, pseudoporphyria*
Danish: Palmoplantar erytrodysæstesi syndrom*, lichenoid keratosis*, lichen planus*, toksisk epidermal nekrolyse*, medikamentelt udslæt med eosinofili og systemiske symptomer (DRESS)* , pseudoporfyri*
English: This study included 7 patients with MDS/MPD who were treated with imatinib 400 mg daily.
Danish: I dette studie indgik 7 patienter med MDS/MPD, som blev behandlet med 400 mg imatinib daglig.
English: HES/CEL (at dose 400 mg)
Danish: HES/CEL (ved 400 mg dosis)
English: Imatinib Actavis is a treatment for:
Danish: Imatinib Actavis bruges til behandling af:
English: When given with a high-fat meal, the rate of absorption of imatinib was minimally reduced (11% decrease in Cmax and prolongation of tmax by 1.5 h), with a small reduction in AUC (7.4%) compared to fasting conditions.
Danish: Når imatinib indtages i forbindelse med et måltid med høj fedtprocent, reduceres absorptionen af imatinib minimalt (11 %'s fald i Cmax og forlængelse af tmax med 1,5 time), med et lille fald i AUC (7,4 %) sammenlignet med fastende.
English: - paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase or blast crisis.
Danish: - børn med Ph+ CML i kronisk fase efter manglende effekt af alfa-interferonbehandling, eller i accelereret fase eller blastkrise.
English: In vitro, imatinib inhibits paracetamol O-glucuronidation with Ki value of 58.5 micromol/L.
Danish: In vitro hæmmer imatinib O-glucuronidationen af paracetamol med en Ki-værdi på 58,5 mikromol/l.
English: Very common (may affect more than 1 in 10 people) or common (may affect up to 1 in 10 people): - Rapid weight gain.
Danish: Meget almindelige (kan forekomme hos flere end 1 ud af 10 mennesker) eller almindelige (kan forekomme op til 1 ud af 10 mennesker): - Hurtig vægtøgning.
English: Imatinib in combination with chemotherapy induction (see Table 3) resulted in a complete haematological response rate of 93% (147 out of 158 evaluable patients) and in a major cytogenetic response rate of 90% (19 out of 21 evaluable patients).
Danish: Imatinib givet i kombination med kemoterapi-induktion (se Tabel 3) resulterede i en komplet hæmatologisk responsrate på 93% (147 ud af 158 evaluerbare patienter), og i en væsentlig cytogenetisk responsrate på 90% (19 ud af 21 evaluerbare patienter).
English: This clinical effect was associated with a higher reduction in bcrabl transcripts in the imatinib-treated patients than in the chemotherapy arm after 2 weeks of therapy (p=0.02).
Danish: Denne kliniske effekt var efter 2 ugers behandling forbundet med en højere reduktion i bcr-abl transkriptionen hos de imatinibbehandlede patienter end i kemoterapiarmen (p=0,02).