FrancophonIA/ELRC3.0 huggingface dataset:
English: For further advice see Further helpful information in the blue pages in section 6.
Croatian: Za dalje savjete pogledajte Ostale korisne informacije na plavim stranicama u dijelu 6.
English: The capsule should be swallowed with water.
Croatian: Kapsulu treba progutati s vodom.
English: It is important that you consult your doctor before taking alli if you are receiving treatment for HIV.
Croatian: Važno je da se konzultirate sa svojim liječnikom prije uzimanja lijeka alli ako primate terapiju za HIV.
English: This fat passes out of your body and may cause changes to your bowel movements.
Croatian: Te masti izlaze iz Vašeg organizma i mogu prouzročiti promjene u stolici.
English: For this reason, a multivitamin supplement should be taken at bedtime.
Croatian: Zbog toga u vrijeme odlaska na počinak treba uzimati multivitaminski dodatak.
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilacijske aktivnosti i intervencije opisane u dogovorenom Planu upravljanja rizikom (RMP) koji se nalazi u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: If you have taken too many capsules, contact a doctor as soon as possible.
Croatian: Uzmete li previše kapsula javite se što prije liječniku.
English: In the absence of pharmacokinetic interaction studies, alli is not recommended to be used by patients receiving acarbose.
Croatian: Budući da nisu provedena farmakokinetička istraživanja interakcija, alli se ne preporučuje bolesnicima koji uzimaju akarbozu.
English: Cases of rectal bleeding have been reported in patients taking orlistat.
Croatian: Prijavljeni su slučajevi krvarenja iz rektuma bolesnika koji su uzimali orlistat.
English: -4.40 a a p<0.001 versus placebo
Croatian: -4,40 a a p<0,001 u odnosu na placebo
English: The effect of orlistat results in an increase in faecal fat as early as 24 to 48 hours after dosing.
Croatian: Zbog tog učinka orlistata poveća se sadržaj masti u fecesu već nakon 24 do 48 sati nakon doziranja.
English: Moderate activity
Croatian: Umjerena aktivnost
English: A. LABELLING
Croatian: A.OZNAČIVANJE
English: Wait and take the next tablet around your next main meal as usual.
Croatian: Pričekajte i iduću tabletu uzmite uz sljedeći obrok, kao i obično.
English: - Hepatitis (inflammation of the liver).
Croatian: - Hepatitis (upala jetre).
English: The possibility of experiencing gastrointestinal symptoms (see section 4.8) may increase when orlistat is taken with an individual meal or a diet high in fat.
Croatian: Mogućnost pojave gastrointestinalnih simptoma (vidjeti dio 4.8) može se povećati pri uzimanju orlistata s određenim vrstama hrane ili s hranom bogatom mastima.
English: Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000) and not known (cannot be estimated from the available data).
Croatian: Prema učestalosti su razvrstane na: vrlo često (≥1/10), često (≥1/100 do <1/10), manje često (≥1/1000 do <1/100), rijetko (≥1/10 000
English: Do not take alli
Croatian: Nemojte uzimati alli
English: Tell your doctor that you are taking alli when you have a blood test.
Croatian: Kažite svom liječniku ako uzimate alli dok radite krvne pretrage.
English: If this occurs, the patient should consult a doctor.
Croatian: Dogodi li se to, bolesnik se mora posavjetovati s liječnikom.
English: Remember to check with your doctor first if you have not exercised before.
Croatian: Ne zaboravite najprije provjeriti s liječnikom ako se ranije niste bavili tjelovježbom.
English: - medicines for depression, psychiatric disorders or anxiousness.
Croatian: - lijekove za depresiju, psihijatrijske poremećaje ili tjeskobu.
English: If you forget to take alli
Croatian: Ako ste zaboravili uzeti alli
English: If you weigh less than the weight shown for your height, do not take alli.
Croatian: Ako Vam je težina manja od one navedene uz Vašu visinu, nemojte uzimati alli.
English: - Moderate activity means you burn around 150 calories per day in physical activity, for example, walking three kilometres (2 miles), gardening for 30 to 45 minutes, or running two kilometres (1.25 miles) in 15 minutes.
Croatian: - Umjerena tjelesna aktivnost znači da dnevno na tjelesne aktivnosti potrošite oko 150 kalorija, npr. da pješačite tri kilometra, da radite u vrtu 30 do 45 minuta, ili da pretrčite dva km u 15
English: - Distribute your fat allowance evenly across your meals for the day.
Croatian: - Unos masti rasporedite ravnomjerno na sve obroke tijekom dana.
English: Pharmacotherapeutic group: antiobesity preparations, excl. diet products, peripherally acting antiobesity products, ATC code A08AB01.
Croatian: Farmakoterapijska skupina: Pripravci za liječenje pretilosti, isključujući dijetalne pripravke, lijekovi za liječenje pretilosti koji djeluju periferno, ATK oznaka A08AB01.
English: alli is contraindicated in pregnancy (see section 4.3).
Croatian: alli je kontraindiciran u trudnoći (vidjeti dio 4.3).
English: Decreased prothrombin and increased INR (see sections 4.3 and 4.5)
Croatian: Snižena vrijednost protrombina i povišen INR (vidjeti dio 4.3 i 4.5)
English: They are sometimes called kilocalories or kcal. Energy may also be measured in kilojoules, which you may also see on food labels.
Croatian: Energija se može mjeriti i kilodžulima, što se također može vidjeti na deklaracijama prehrambenih proizvoda.
English: Based on animal data, it is likely that the metabolism of orlistat occurs mainly within the gastrointestinal wall.
Croatian: Podaci dobiveni u životinja pokazuju da se metabolizam orlistata vjerojatno zbiva uglavnom unutar stijenki gastrointestinalnog sustava.
English: - Severe stomach pain caused by gallstones.
Croatian: - Jaka bol u trbuhu, prouzročena žučnim kamencima.
English: M1 and M3 have an open beta-lactone ring and extremely weak lipase inhibitory activity (1,000and 2,500-fold less than orlistat, respectively).
Croatian: M1 i M3 sadržavaju otvoreni beta-laktonski prsten i imaju krajnje slabu inhibicijsku aktivnost na lipazu (1000 odnosno 2500 puta manje od orlistata).
English: However, orlistat may indirectly reduce the availability of oral contraceptives and lead to unexpected pregnancies in some individual cases.
Croatian: No orlistat može neizravno smanjiti raspoloživost oralnih kontraceptiva i tako omogućiti da u pojedinim slučajevima nastupi neočekivana trudnoća.
English: The following chart shows how to set your fat target based on the amount of calories you are allowed per day.
Croatian: Sljedeća tablica pokazuje kako odrediti ciljnu količinu masti na temelju broja kalorija koji smijete dnevno unijeti.
English: Tell your doctor or pharmacist if any of these side effects gets severe or troublesome.
Croatian: Kažite liječniku ili ljekarniku postane li koja od tih nuspojava jaka ili Vam stvara poteškoće.
English: While taking orlistat, the patient should be on a nutritionally balanced, mildly hypocaloric diet that contains approximately 30% of calories from fat (e.g. in a 2,000 kcal/day diet, this equates to <67 g of fat).
Croatian: Za vrijeme uzimanja orlistata osoba mora biti na nutricijski uravnoteženoj, blago hipokaloričnoj dijeti u kojoj oko 30% kalorija potječe od masti (npr. u dijeti s 2000 kcal/dan, to odgovara količini <67g masti).
English: Severe allergic reactions - Signs of a severe allergic reaction include: severe breathing difficulties, sweating, rash, itching, swollen face, rapid heart beat, collapse.
Croatian: - Znakovi teških alergijskih reakcija uključuju: teške smetnje disanja, znojenje, osip, oteknuće lica, ubrzani otkucaji srca, kolaps.
English: When stored in the carry case: 1 month.
Croatian: Kod čuvanja u priručnom spremniku: 1 mjesec.
English: Adverse reactions to orlistat are largely gastrointestinal in nature and related to the pharmacologic effect of the medicinal product on preventing the absorption of ingested fat.
Croatian: Nuspojave pri uzimanju orlistata po svojoj su naravi uglavnom gastrointestinalne, i povezane s farmakološkim učinkom lijeka na sprječavanje apsorpcije unesene masti.
English: If you have taken too many tablets, contact a doctor as soon as possible.
Croatian: Uzmete li previše tableta javite se što prije liječniku.
English: What alli is and what it is used for Risk of being overweight
Croatian: Što se nalazi u ovoj uputi: Što je alli i za što se koristi Rizik od prekomjerne tjelesne težine
English: - Find out more about how much fat your favourite foods typically contain, and the size of your portions.
Croatian: - Saznajte više o tome koliko masti sadržava hrana koju volite i o veličini obroka koje uzimate.
English: The gastrointestinal adverse reactions identified from clinical trials with orlistat 60 mg of 18 months to 2 years duration were generally mild and transient.
Croatian: Gastrointestinalne nuspojave uočene u kliničkim istraživanjima orlistata 60 mg, koja su trajala od 18 mjeseci do 2 godine, bile su općenito blage i prolazne.
English: From clinical studies, it has been estimated that orlistat 60 mg taken three times daily blocks the absorption of approximately 25% of dietary fat.
Croatian: Na temelju rezultata kliničkih istraživanja, procijenjeno je da orlistat 60 mg, uzet triput na dan, blokira apsorpciju oko 25 % unesenih masti.
English: In view of this low inhibitory activity and the low plasma levels at therapeutic doses (average of 26 ng/ml and 108 ng/ml, respectively), these metabolites are considered to be pharmacologically inconsequential.
Croatian: Radi ove niske inhibicijske aktivnosti i niskih razina u plazmi pri terapijskim dozama (prosjek od 26 ng/ml odnosno 108 ng/ml) ti se metaboliti smatraju farmakološki beznačajnima.
English: It may be necessary to discontinue treatment.
Croatian: Možda će biti potrebno prekinuti uzimanje lijeka.
English: - Swallow the capsule whole with water.
Croatian: - Kapsulu progutajte cijelu, s vodom.
English: Maximum amount of fat allowed per meal
Croatian: Najveća količina masti dopuštena po jednom obroku
English: Women Low activity
Croatian: Žene Slaba aktivnost
English: - Continue to be active while taking alli and after you stop taking it.
Croatian: - Nastavite s tjelesnim aktivnostima za vrijeme dok uzimate alli i nakon što ga prestanete uzimati.
English: Each chewable tablet contains 86.79 mg of lactose (as anhydrous) and 6.48 mg of sucrose (as monopalmitate).
Croatian: Jedna tableta za žvakanje sadržava 86.79 mg laktoze (bezvodne) i 6.48 mg saharoze (monopalmitat).
English: Visit <www.xxx.xxx>
Croatian: Posjetite <www.xxx.xxx>
English: It is possible that the systemic absorption from 27 mg chewable tablets may be higher than that from 60 mg hard capsules.
Croatian: Moguće je da sistemska apsorpcija 27 mg tablete bude viša, nego što je to kod 60 mg tvrde kapsule.
English: Do not use
Croatian: Ne uzimajte
English: If a meal is missed or contains no fat, the dose of orlistat should be omitted.
Croatian: Ako se obrok propusti ili ne sadržava masti, dozu orlistata treba propustiti.
English: The inactivated enzyme is thus unavailable to hydrolyse dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides.
Croatian: Inaktivirani enzim stoga ne može hidrolizirati masti iz hrane, koje se nalaze u obliku triglicerida, i pretvoriti ih u slobodne masne kiseline i monogliceride koji se mogu apsorbirati.
English: Pharmacodynamic equivalence of alli 27 mg chewable tablets and alli 60 mg hard capsules has been established using a faecal fat excretion model.
Croatian: Farmakodinamska ekvivalencija alli 27 mg tableta za žvakanje i alli 60 mg tvrdih kapsula ustanovljena je na temelju modela ekskrecije masti putem fecesa.
English: Patients should be advised to adhere to the dietary recommendations they are given (see section 4.2).
Croatian: Bolesnicima treba savjetovati da se pridržavaju dobivenih uputa o dijeti (vidjeti dio 4.2).
English: Your calorie target alone should allow you to lose weight at a gradual, steady pace of about 0.5 kg (1 lb) per week, without feeling frustrated or deprived.
Croatian: Vaš ciljni broj kalorija mora Vam dozvoljavati gubitak težine postupenim, stalnim tempom od otprilike 0,5 kg tjedno, bez osjećaja frustracije ili uskraćenosti.
English: So by meeting your fat target, you will maximise weight loss results while minimising the risk of diet-related treatment effects.
Croatian: Stoga, budete li se pridržavali unosa ciljne količine masti, postići ćete najbolji mogući rezultat u smanjivanju tjelesne težine, istodobno smanjujući na najmanju moguću mjeru rizik od učinka lijeka povezanih s prehranom.
English: Skin and subcutaneous tissue disorders Not known
Croatian: Poremećaji kože i potkožnog tkiva Nepoznato
English: - Your fat gram target is the maximum number of grams of fat you will eat in each meal.
Croatian: - Ciljna količina masti je broj grama masti koje ćete uzeti svakim obrokom.
English: How to use
Croatian: Kako uzimati
English: - Write down what you eat in a food diary, including the calorie and fat content.
Croatian: - Zapišite u dnevnik prehrane što jedete, uključujući broj kalorija i količinu masti.
English: Bullous eruption
Croatian: Bulozne erupcije
English: If this occurs, consideration could be given to administering orlistat and antiepileptic medicinal products at different times (see section 4.5).
Croatian: Dogodi li se to, valja razmotriti primjenu orlistata i antiepileptika u različito vrijeme (vidjeti dio 4.5).
English: C. OTHER CONDITIONS AND REQUIRMENTS OF THE MARKETING AUTHORISATION
Croatian: C OSTALI UVJETI I ZAHTJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: - if you are taking ciclosporin.
Croatian: - ako uzimate ciklosporin.
English: The majority of orlistat overdose cases received during post-marketing reported either no adverse reactions or adverse reactions that are similar to those reported with recommended doses of orlistat.
Croatian: većini slučajeva predoziranja orlistatom, prijavljenih nakon stavljanja lijeka u promet nije bilo nuspojava ili su bile slične onima prijavljenima pri uzimanju preporučenih doza orlistata.
English: A decrease in ciclosporin plasma levels has been observed in a drug-drug interaction study and also reported in several cases, when orlistat was administered concomitantly.
Croatian: Sniženje razina ciklosporina u plazmi uočeno je u istraživanju interakcije među lijekovima, a i prijavljeno je u nekoliko slučajeva, kada se istodobno davao i orlistat.
English: Chew one tablet three times a day.
Croatian: Žvačite jednu tabletu tri puta na dan.
English: - Capsule band: gelatin, polysorbate 80, indigo carmine (E132).
Croatian: - Prsten kapsule: želatina, polisorbat 80, Indigo Carmine (E132).
English: Tell your doctor if you get any of these.
Croatian: Kažite liječniku, pojavi li se išta od toga.
English: The vast majority of subjects receiving up to 4 full years of treatment with orlistat in clinical studies had vitamin A, D, E and K and beta-carotene levels that stayed within normal range.
Croatian: U velike većine ispitanika koji su u kliničkim istraživanjima primali orlistat do 4 pune godine, razine vitamina A, D, E i K te beta-karotena zadržale su se unutar granica referentnog raspona.
English: How alli works
Croatian: Kako alli djeluje
English: It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine site of the gastric and pancreatic lipases.
Croatian: Terapijsko djelovanje iskazuje u lumenu želuca i tankog crijeva, stvarajući kovalentnu vezu s aktivnim serinskim mjestom želučane i pankreasne lipaze.
English: Medicinal products for hypertension or hypercholesterolaemia Weight loss may be accompanied by an improvement in blood pressure and cholesterol levels.
Croatian: Lijekovi za liječenje hipertenzije ili hiperkolesterolemije Gubitak tjelesne težine može biti praćen poboljšanjem vrijednosti krvnog tlaka i kolesterola.
English: How to take alli
Croatian: Kako uzimati alli
English: Make every effort to avoid any high-fat meals while taking alli.
Croatian: Učinite sve što možete da za vrijeme dok uzimate alli izbjegnete bilo koji obrok s visokim sadržajem masti.
English: Tηλ.
Croatian: Λ.
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicinal product.
Croatian: Bolesnici koji pate od nasljednih problema netolerancije galaktoze, manjka Lapp laktoze, glukoza-galaktoza malapsorpcije ili saharoza-izomaltoza insuficijencije, ne smiju uzimati ovaj lijek.
English: What alli looks like and contents of the pack alli capsules have a turquoise cap and body, with a dark blue band round the middle, imprinted with "alli".
Croatian: Kako alli izgleda i sadržaj pakiranja alli kapsule imaju tirkiznu kapicu i tijelo, s tamnoplavim prstenom oko središnjeg dijela i otisnutom oznakom „alli“.
English: • take one capsule whole with water, three times a day with each main meal containing fat.
Croatian: • uzmite jednu cijelu kapsulu s vodom, tri puta dnevno sa svakim obrokom koji sadrži masnoće.
English: - Controlling your fat target is essential because of the way the capsules work.
Croatian: - Nadzor nad ciljnom količinom masti ključan je zbog načina na koji kapsule djeluju.
English: The effect of orlistat in individuals with hepatic and/or renal impairment has not been studied (see section 4.4).
Croatian: Učinci orlistata u osoba s jetrenim i/ili bubrežnim oštećenjem nisu istraženi (vidjeti dio 4.4).
English: - Take alli just before, during or up to one hour after meals.
Croatian: - alli uzimajte neposredno prije, za vrijeme ili do jedan sat nakon jela.
English: White to off-white, faceted, triangular shaped tablets of 12 mm, debossed with “alli”.
Croatian: Bijele do gotovo bijele, brušenih rubova, trokutaste tablete od 12 mm, s utisnutom oznakom “alli”.
English: - if you are taking a medicine for high blood pressure.
Croatian: - ako uzimate lijekove za visoki krvni tlak.
English: These may affect up to 1 in 10 people - Stomach (abdominal) pain.
Croatian: Mogu se javiti u do 1 na 10 osoba - Bol u trbuhu (abdomenu) - Inkontinencija (stolice)
English: D. CONDITIONS OR RESTRICTIONS WITH REGARD SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Croatian: D UVJETI ILI OGRANIČENJA VEZANI UZ SIGURNU I UČINKOVITU PRIMJENU
English: Taking alli means your body will pass more fat through, and therefore may struggle to cope with eating as much fat as before.
Croatian: Kad uzimate alli Vaše tijelo odstranjuje više masti, pa ćete možda osjetiti potrebu da jedete onoliko masti koliko ste jeli i prije.
English: That adds up to 3500 fewer calories per week, about the number of calories in 0.5 kg (1 lb) of fat.
Croatian: To znači do 3500 kalorija manje na tjedan, što odgovara broju kalorija u 0,5 kg masti.
English: Such effects typically occur within the first few weeks of using the capsules, before you may have learnt to limit the amount of fat in your diet.
Croatian: Ti se učinci obično javljaju unutar prvih nekoliko tjedana uzimanja kapsula, prije nego što ste možda naučili ograničiti količinu masti u svojoj prehrani.
English: - Skin blistering (including blisters that burst).
Croatian: - Mjehurići po koži (uključujući mjehure koji pucaju).
English: alli is available in pack sizes of 42, 60, 84, 90 and 120 capsules.
Croatian: alli je dostupan u pakiranju po 42, 60, 84, 90 ili 120 kapsula.
English: Before you start taking the tablets, begin your reduced calorie, lower-fat diet and give your body a few days to adjust to your new eating habits.
Croatian: Prije nego ih počnete uzimati, počnite provoditi dijetu s manje kalorija i manje masti, i omogućite tijelu nekoliko dana da se prilagodi novim prehrambenim navikama.
English: The recommended treatment dose is one 60 mg capsule to be taken three times daily.
Croatian: Preporučena terapijska doza je po jedna 60 mg kapsula triput na dan.
English: Patients who are taking amiodarone should consult a doctor before starting treatment with alli (see section 4.5).
Croatian: Bolesnici koji uzimaju amiodaron trebaju se posavjetovati s liječnikom prije nego što počnu uzimati alli (vidjeti dio 4.5).
English: The medicinal use of orlistat is unlikely to represent a risk to the aquatic or terrestrial environment.
Croatian: Medicinska primjena orlistata malo vjerojatno predstavlja rizik za vodeni i zemljani okoliš.
English: Such effects typically occur within the first few weeks of using the tablets, before you may have learnt to limit the amount of fat in your diet.
Croatian: Ti se učinci obično javljaju unutar prvih nekoliko tjedana uzimanja tableta, prije nego što ste možda naučili ograničiti količinu masti u svojoj prehrani.
English: - If you are taking ciclosporin, used after organ transplants, for severe rheumatoid arthritis and some severe skin conditions.
Croatian: Ako uzimate ciklosporin, koji se daje nakon presađivanja organa, za teški reumatoidni artritis i za neka teška kožna stanja.
English: No more than three 27 mg tablets should be taken in 24 hours.
Croatian: Tijekom 24 sata ne smiju se uzeti više od 3 tablete od 27 mg.
English: How to set your calorie target
Croatian: Kako odrediti ciljni broj kalorija
English: Keep the canisters in the bottle.
Croatian: Ostavite spremnike sa silikagelom u boci.
English: ANNEX II A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Croatian: PROMET B. UVJETI ILI OGRANIČENJA VEZANI UZ OPSKRBU I PRIMJENU C. OSTALI UVJETI I ZAHTJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: The recommended treatment dose is one 27 mg tablet to be taken three times daily.
Croatian: Preporučena terapijska doza je po jedna 27 mg tableta triput na dan.
English: Most of the common side effects related to alli (for example, wind with or without oily spotting, sudden or more frequent bowel motions and soft stools) are caused by the way it works (see section 1).
Croatian: Većina čestih nuspojava povezanih s alli kapsulama (na primjer vjetrovi koji mogu biti praćeni izlučivanjem masti, iznenadno ili češće pražnjenje crijeva i meke stolice) javlja se zbog načina na koji alli djeluje (pogledajte dio 1).
English: A realistic goal is to lose between 5 % to 10 % of your starting weight.
Croatian: Realni je cilj početnu tjelesnu težinu smanjiti za 5 do 10 %.
English: Studies in normal weight and obese volunteers have shown that the extent of absorption of orlistat was minimal.
Croatian: Ispitivanja u dobrovoljaca s normalnom tjelesnom težinom i onih pretilih pokazali su da je opseg apsorpcije orlistata minimalan.
English: The following table has been worked out so that it gives you a calorie target that is about 500 calories fewer per day than your body needs to maintain your current weight.
Croatian: U tablici niže navedeni su ciljni brojevi kalorija, a određeni su tako da na dan unesete oko 500 kalorija manje nego što ih tijelu treba za održavanje postojeće težine.
English: For adults with a BMI of 28 or above
Croatian: Za odrasle s indeksom tjelesne mase (BMI) 28 ili iznad
English: EXP In the carry case: 1 month
Croatian: U priručnom spremniku: 1 mjesec
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT Holds 3 tablets.
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI DOZNOJ JEDINICI LIJEKA Sadržava 3 tablete.
English: In general, at therapeutic doses, detection of intact orlistat in plasma was sporadic and concentrations were extremely low (<10 ng/ml or 0.02 µmol), with no evidence of accumulation, which is consistent with minimal absorption.
Croatian: Općenito pri terapijskim se dozama orlistat u plazmi mogao dokazati samo sporadično i u krajnje niskim koncentracijama (<10 ng/ml ili 0,02 µmol), bez znakova nakupljanja, što je u skladu s njegovom minimalnom apsorpcijom.
English: Adults 18 and over
Croatian: Odrasli u dobi od 18 godina i stariji