FrancophonIA/ELRC3.0 huggingface dataset:
English: Immune system disorders: rare: hypersensitivity: anaphylactic reactions, angiooedema including swelling of the larynx and glottis causing airway obstruction and/or swelling of the face, lips, pharynx, and/or tongue; in some of these patients angiooedema had been reported in the past in connection with the administration of other medicines, including ACE inhibitors; vasculitis, including Henoch-Schönlein purpura.
Slovenian: Bolezni imunskega sistema: redke: preobčutljivost: anafilaktične reakcije, angioedem vključno z otekanjem grla in glotisa, zaradi česar se zožijo dihalne poti, in/ali otekanjem obraza, ustnic, žrela in/ali jezika - pri nekaterih od teh bolnikov so v preteklosti poročali o angioedemu v povezavi z jemanjem drugih zdravil, vključno z zaviralci ACE; vaskulitis vključno s Henoch-Schönleinovo purpuro.
English: Always shake <COZAAR>oral suspension well before use!
Slovenian: Pred uporabo suspenzijo COZAAR vedno dobro pretresite!
English: • non-steroidal anti-inflammatory drugs such as indomethacin, including cox-2-inhibitors (medicines that reduce inflammation, and can be used to help relieve pain), as they may reduce the blood lowering effect of losartan.
Slovenian: • nesteroidna protivnetna zdravila, kot je indometacin, vključno z zaviralci COX-2 (zdravila, ki zdravijo vnetje in se lahko uporabljajo za odpravljanje bolečine), ker lahko zmanjšajo losartanov učinek znižanja krvnega tlaka.
English: Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patients, a lower dose should be considered for patients with a history of hepatic impairment.
Slovenian: Glede na farmakokinetične podatke, ki kažejo pomembno zvišanje plazemskih koncentracij losartana pri bolnikih s cirozo, je treba pri bolnikih, ki so kdaj imeli okvaro jeter, razmisliti o manjšem odmerku.
English: • if you receive diuretics (medicines that increase the amount of water that you pass out through your kidneys) or are under dietary salt restriction leading to an extreme loss of fluid and salt in your body (see section 3 ‘Dosage in special patient groups'),
Slovenian: • če jemljete diuretike (zdravila, ki povečajo izločanje vode skozi ledvice) ali ste na dieti s hrano z zmanjšano količino soli, zaradi česar iz telesa izgubljate večje količine tekočine in soli (glejte poglavje 3 "Odmerjanje pri posebnih skupinah bolnikov").
English: Taking with food and drink COZAAR may be taken with or without food.
Slovenian: Jemanje zdravila skupaj s hrano in pijačo Zdravilo COZAAR lahko vzamete s hrano ali na tešče.
English: About 14 % of an intravenously- or orally-administered dose of losartan is converted to its active metabolite.
Slovenian: Približno 14 % intravenskega ali peroralnega odmerka losartana se pretvori v njegov aktivni presnovek.
English: • to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6 - 16 years of age.
Slovenian: • za zdravljenje bolnikov z visokim krvnim tlakom (hipertenzijo) pri odraslih ter pri otrocih in mladostnikih, starih 6-16 let.
English: Reduction in the risk of stroke in hypertensive patients with left-ventricular hypertrophy documented by ECG
Slovenian: Zmanjšanje tveganja za možgansko kap pri hipertenzivnih bolnikih s hipertrofijo levega prekata, potrjeno z EKG-jem
English: When angiotensin II antagonists are administered simultaneously with NSAIDs (i.e. selective COX-2 inhibitors, acetylsalicylic acid at anti-inflammatory doses and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Slovenian: Če se antagonisti angiotenzina II uporabljajo sočasno z nesteroidnimi protivnetnimi učinkovinami (NSAID) (npr. selektivnimi zaviralci COX-2, acetilsalicilno kislino v protivnetnih odmerkih in neselektivnimi NSAID-i), se lahko antihipertenzivni učinek zmanjša.
English: Merck Sharp Dohme Chibret 3 av. Hoche
Slovenian: Francija Merck Sharp Dohme Chibret 3 av. Hoche
English: • in patients with high blood pressure and a thickening of the left ventricle, COZAAR has been shown to decrease the risk of stroke (“LIFE indication”).
Slovenian: • pri bolnikih z visokim krvnim tlakom in zadebeljenim levim prekatom zdravilo COZAAR zmanjša tveganje za možgansko kap ("indikacija iz študije LIFE").
English: Therefore the results observed with losartan in comparison with atenolol in the LIFE study with regard to cardiovascular morbidity/mortality do not apply for black patients with hypertension and left-ventricular hypertrophy.
Slovenian: Zato rezultati glede srčno-žilne obolevnosti/smrtnosti iz študije LIFE za losartan v primerjavi z atenololom ne veljajo za bolnike črne rase s hipertenzijo in hipertrofijo levega prekata.
English: • Treatment of essential hypertension in adults and in children and adolescents 6 - 16 years of age.
Slovenian: • Zdravljenje esencialne hipertenzije pri odraslih ter otrocih in mladostnikih, starih 6 - 16 let.
English: Store the prepared suspension in a refrigerator at 2-8°C.
Slovenian: Pripravljeno suspenzijo shranjujte v hladilniku pri 2-8 ºC.
English: After reconstitution, store the liquid suspension in a refrigerator (at 2°C - 8°C) for up to 4 weeks.
Slovenian: Po pripravi tekočo suspenzijo shranjujte v hladilniku (pri 2 ºC do 8 ºC) do 4 tedne.
English: Concomitant use with other substances which may induce hypotension as an adverse reaction (like tricyclic antidepressants, antipsychotics, baclofen, and amifostine) may increase the risk of hypotension.
Slovenian: Sočasna uporaba z drugimi učinkovinami, ki imajo za neželeni učinek lahko hipotenzijo (kot triciklični antidepresivi, antipsihotiki, baklofen in amifostin) lahko poveča tveganje za hipotenzijo.
English: Cardiac disorders: rare: syncope, atrial fibrillation, cerebrovascular accident
Slovenian: Srčne bolezni: redke: sinkopa, atrijska fibrilacija, možganskožilni dogodek
English: Losartan slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.
Slovenian: Losartan upočasni pešanje ledvic pri bolnikih z visokim krvnim tlakom in sladkorno boleznijo tipa 2.
English: PHARMACEUTICAL FORM AND CONTENTS 200 ml oral suspension
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 200 ml peroralne raztopine
English: The recommended starting dose in patients >20 to <50 kg is 0.7 mg/kg once daily (up to 25 mg total, in exceptional cases where target doses above 25 mg are required, the maximal dose is 50 mg).
Slovenian: Priporočeni začetni odmerek pri bolnikih > 20 do < 50 kg je 0,7 mg/kg enkrat na dan (do skupno 25 mg, v izjemnih primerih, ko so potrebni odmerki nad 25 mg, je največji odmerek 50 mg).
English: PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: Angiotensin II antagonists, plain, ATC code: C09CA01 5.1 Pharmacodynamic properties
Slovenian: Farmakoterapevtska skupina: antagonisti angiotenzina II, enokomponentna zdravila, oznaka ATC: C09CA01
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION <{DD month YYYY}> [To be completed nationally]
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET {DD/MM/LLLL} [Izpolni država članica]
English: Hypertension and type 2 diabetes with renal disease In a controlled clinical trial in 1513 type 2 diabetic patients 31 years of age and older with proteinuria (RENAAL study, see section 5.1) the most common drug-related adverse reactions which were reported for losartan are as follows:
Slovenian: Hipertenzija in sladkorna bolezen tipa 2 z boleznijo ledvic V kontroliranem kliničnem preskušanju pri 1513 bolnikih, starih 31 let in več, s sladkorno boleznijo tipa 2 in proteinurijo (študija RENAAL, glejte poglavje 5.1) so najpogostejši z zdravilom povezani neželeni učinki, o katerih so poročali za losartan, sledeči:
English: The solvent is a cloudy, colorless liquid.
Slovenian: Vehikel je motna, brezbarvna tekočina.
English: The dose-response relationship became very obvious in the low dose group compared to the middle dose group (period I: -6.2 mmHg vs. -11.65 mmHg), but was attenuated when comparing the middle dose group with the high dose group (period I: -11.65 mmHg vs. -12.21 mmHg).
Slovenian: Razlika v odzivu na odmerek med skupinama z majhnim in srednjim odmerkom je bila zelo očitna (obdobje I: -6,2 mmHg proti -11,65 mmHg), in je bila med skupinama s srednjim in velikim odmerkom (obdobje I: -11,65 mmHg proti -12,21 mmHg) manjša.
English: The side effects of medicines are classified as follows:
Slovenian: Neželeni učinki so razvrščeni kot je navedeno:
English: PHARMACEUTICAL FORM Powder and solvent for oral suspension.
Slovenian: FARMACEVTSKA OBLIKA Prašek in vehikel za peroralno suspenzijo.
English: Shake the closed bottle of losartan oral suspension well before use.
Slovenian: Zaprto plastenko peroralne suspenzije losartana pred uporabo dobro pretresite.
English: - In some patients the dose may later be increased to 100 mg losartan (40 ml of COZAAR suspension) once daily.
Slovenian: Pri nekaterih bolnikih se odmerek kasneje lahko poveča na 100 mg losartana (40 ml COZAAR suspenzije) enkrat na dan.
English: MSD Chibropharm GmbH Postfach 1202 D-85530 Haar, Germany
Slovenian: Nemčija MSD Chibropharm GmbH Postfach 1202 D-85530
English: These conditions should be corrected prior to administration of losartan, or a lower starting dose should be used (see section 4.2).
Slovenian: Pred začetkom zdravljenja z losartanom je treba ta stanja pozdraviti ali pa uporabiti manjši začetni odmerek (glejte poglavje 4.2).
English: For Healthcare providers only: See Package Leaflet for instructions on how to prepare Losartan potassium oral suspension.
Slovenian: Samo za zdravstveno osebje: za navodila, kako pripraviti peroralno suspenzijo kalijevega losartanata, glejte Navodilo za uporabo.
English: Losartan should be used with caution in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.
Slovenian: Losartan je treba pri bolnikih z obojestranskim zoženjem ledvične arterije ali zoženjem arterije ene same delujoče ledvice previdno uporabljati.
English: This applies particularly when losartan is given in the presence of other conditions (fever, dehydration) likely to impair renal function.
Slovenian: To velja še posebej takrat, ko se losartan daje ob prisotnosti drugih stanj, ki lahko okvarijo ledvice (zvišana telesna temperatura, dehidracija).
English: Merck Sharp & Dohme Bulgaria EOOD
Slovenian: Bolgarija Merck Sharp & Dohme Bulgaria EOOD
English: Because of the potential for adverse effects on the nursing infant, losartan is contraindicated during breast-feeding (see section 4.3).
Slovenian: Zaradi možnih neželenih učinkov na dojenčka je losartan v času dojenja kontraindiciran (glejte poglavje 4.3).
English: The difference in blood pressure increase as compared to placebo was largest in the middle dose group (6.70 mm Hg middle dose vs.
Slovenian: Razlika v povečanju krvnega tlaka v času, ko je učinek zdravila najmanjši, v primerjavi s placebom je bila večja v skupini s srednjim odmerkom (6,70 mmHg srednji odmerek, 5,38 mmHg večji odmerek).
English: For more information, talk to your doctor.
Slovenian: Za več informacij prosite zdravnika.
English: The suspension should be stored in a refrigerator at 2-8ºC for up to 4 weeks.
Slovenian: Suspenzijo shranjujte v hladilniku pri 2-8 ºC do 4 tedne.
English: Losartan may be administered with other antihypertensive agents, especially with diuretics (e.g. hydrochlorothiazide).
Slovenian: Losartan se lahko jemlje skupaj z drugimi antihipertenzivnimi zdravili, še posebej z diuretiki (npr. hidroklorotiazidom).
English: Investigations: common: hypoglycaemia, hyperkalaemia
Slovenian: Preiskave: pogoste: hipoglikemija, hiperkaliemija
English: In a clinical study conducted in type 2 diabetic patients with nephropathy, the incidence of hyperkalemia was higher in the group treated with losartan as compared to the placebo group (see section 4.8).
Slovenian: V klinični študiji pri bolnikih s sladkorno boleznijo tipa 2 in nefropatijo je bila pojavnost hiperkaliemije večja v skupini, ki je prejemala losartan, kot v skupini, ki je prejemala placebo (glejte poglavje 4.8).
English: -It is not recommended in children with glomerular filtration rate < 30 ml/ min / 1.73 m2, as no data are available (see also section 4.4).
Slovenian: - Losartana ne priporočamo za uporabo pri otrocih, ki imajo hitrost glomerulne filtracije < 30 ml/min/1,73 m2, ker ni na voljo nobenih podatkov (glejte tudi poglavje 4.4).
English: LABORATÓRIO MEDINFAR, Produtos Farmacêuticos, SA Rua Manuel Ribeiro de Pavia, 1-1° Venda Nova
Slovenian: Portugalska LABORATÓRIO MEDINFAR, Produtos Farmacêuticos, SA Rua Manuel Ribeiro de Pavia, 1-1°
English: Special caution is necessary when you are treated with a ßblocker concomitantly,
Slovenian: Posebna previdnost je potrebna, če sočasno jemljete beta zaviralec.
English: In a clinical study conducted in type 2 diabetic patients with nephropathy, 9.9 % of patients treated with Losartan tablets developed hyperkalaemia >5.5 mEq/l and 3.4 % of patients treated with placebo Post-marketing experience
Slovenian: V klinični študiji, ki so jo izvedli pri bolnikih s sladkorno boleznijo tipa 2 in nefropatijo, se je hiperkaliemija > 5,5 mEq/l pojavila pri 9,9 % bolnikov, zdravljenih z losartanom, ter 3,4 % bolnikov, ki so prejemali placebo.
English: COZAAR powder is a white to off-white powder.
Slovenian: COZAAR prašek je bel do sivo-bel prašek.
English: • a 473 ml white, high-density polyethylene (HDPE) bottle of solvent,
Slovenian: • 473 ml vehikla v beli HDPE plastenki (high-density polyethylene - polietilen visoke gostote)
English: • if your liver function is severely impaired,
Slovenian: • če imate hudo okvaro jeter,
English: Merck Sharp & Dohme OÜ Peterburi tee 46
Slovenian: Estonija Merck Sharp & Dohme OÜ Peterburi tee 46
English: The following side effects have been reported with COZAAR:
Slovenian: Poročali so o naslednjih neželenih učinkih zdravila COZAAR:
English: HOW TO TAKE COZAAR
Slovenian: KAKO JEMATI ZDRAVILO COZAAR
English: Losartan is not recommended in children with glomerular filtration rate < 30 ml/ min/1.73 m2as no data are available (see section 4.2).
Slovenian: Losartana ne priporočamo za uporabo pri otrocih, ki imajo hitrost glomerulne filtracije < 30 ml/min/1,73 m2, ker ni na voljo nobenih podatkov (glejte poglavje 4.2).
English: ANNEX II SUMMARY OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET
Slovenian: DODATEK IIPOVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJE IN NAVODILO ZA UPORABO
English: It was found that concomitant treatment of losartan with rifampicine (inducer of metabolism enzymes) gave a 40 % reduction in plasma concentration of the active metabolite.
Slovenian: Ugotovili so, da je pri sočasnem zdravljenju z losartanom in rifampicinom (induktor presnovnih encimov) plazemska koncentracija aktivnega presnovka manjša za 40 %.
English: Losartan therapy exposure during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see also section 5.3 ).
Slovenian: Znano je, da izpostavljenost losartanu v drugem in tretjem trimesečju nosečnosti lahko povzroči fetotoksične učinke pri človeku (zmanjšano delovanje ledvic, oligohidramnija, zapoznela zakostenitev lobanje) in toksične učinke pri novorojenčku (odpoved ledvic, hipotenzija, hiperkaliemija) (glejte tudi poglavje 5.3).
English: WHAT COZAAR IS AND WHAT IT IS USED FOR Losartan (COZAAR) belongs to a group of medicines known as angiotensin-II receptor antagonists.
Slovenian: Losartan (COZAAR) spada v skupino zdravil, imenovanih antagonisti receptorjev angiotenzina II.
English: As with other medicinal products that block angiotensin II or its effects, concomitant use of other medicinal products which retain potassium (e.g. potassium-sparing diuretics: amiloride, triamterene, spironolactone) or may increase potassium levels (e.g. heparin), potassium supplements or salt substitutes containing potassium may lead to increases in serum potassium.
Slovenian: Kot pri drugih zdravilih, ki zavirajo angiotenzin II ali njegove učinke, lahko sočasna uporaba drugih zdravil, ki zadržujejo kalij (npr. diuretikov, ki varčujejo kalij, amilorida, triamterena, spironolaktona) ali lahko povečajo količino kalija (npr. heparin), dodatkov kalija ali nadomestkov soli, ki vsebujejo kalij, povzroči zvišanje vrednosti kalija v serumu.
English: Merck Sharp & Dohme, inovativna zdravila d.o.o., Šmartinska cesta 140, 1000 Ljubljana, Slovenia
Slovenian: Slovenija Merck Sharp & Dohme, inovativna zdravila d.o.o., Šmartinska cesta 140, 1000
English: Doses above 1.4 mg/kg (or in excess of 100 mg) daily have not been studied in pediatric patients.
Slovenian: V izjemnih primerih se odmerek lahko prilagodi do največ 100 mg enkrat na dan. Odmerki nad 1,4 mg/kg (ali nad 100 mg) na dan pri pediatričnih bolnikih niso bili preizkušani.
English: • to protect the kidney in hypertensive type 2 diabetic patients with laboratory evidence ofimpaired renal function and proteinuria ≥ 0.5 g per day (a condition in which urine contains an abnormal amount of protein).
Slovenian: • za zaščito ledvic pri bolnikih s hipertenzijo in sladkorno boleznijo tipa 2, pri katerih so laboratorijski izvidi pokazali okvaro ledvic in proteinurijo ≥ 0,5 g na dan (stanje s preveliko količino beljakovin v urinu).
English: Following oral and intravenous administration of 14C-labeled losartan potassium, circulating plasma radioactivity primarily is attributed to losartan and its active metabolite.
Slovenian: Radioaktivnost plazme po peroralni in intravenski aplikaciji s 14C označenega kalijevega losartanata pripisujemo predvsem losartanu in njegovemu aktivnemu presnovku.
English: • One 240 ml bottle with a child resistant closure for mixing the suspension
Slovenian: • 240 ml plastenko z za otroke varno zaporko za pripravo suspenzije
English: Investigations: uncommon: increase in blood urea, serum creatinine and serum potassium has been reported.
Slovenian: Občasno: poročali so o zvišanih vrednosti sečnine v krvi ter kreatinina in kalija v serumu.
English: The plasma concentrations of the active metabolite are not altered in patients with renal impairment or in haemodialysis patients.
Slovenian: Plazemske koncentracije aktivnega presnovka se pri bolnikih z okvaro ledvic ali bolnikih na hemodializi ne razlikujejo.
English: Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hours, respectively.
Slovenian: Najvišja srednja koncentracija losartana in njegovega aktivnega presnovka je dosežena po 1 oz. 3-4 urah.
English: • medicines which retain potassium or may increase potassium levels (e.g. potassium supplements, potassium-containing salt substitutes or potassium-sparing medicines such as certain diuretics [amiloride, triamteren, spironolactone] or heparine),
Slovenian: • zdravila, ki zadržujejo kalij ali lahko povečajo količino kalija (npr. dodatki kalija, nadomestki soli, ki vsebujejo kalij, zdravila, ki varčujejo kalij, kot so določeni diuretiki [amilorid, triamteren, spironolakton], ali heparin).
English: Reconstitution of COZAAR oral suspension [for 200 ml of a 2.5 mg/ml suspension]:
Slovenian: Priprava COZAAR peroralne suspenzije [za 200 ml suspenzije s koncentracijo 2,5 mg/ml]:
English: There is no sufficient therapeutic experience with losartan in patients with heart failure and concomitant severe renal impairment, in patients with severe heart failure (NYHA class IV) as well as in patients with heart failure and symptomatic life-threatening cardiac arrhythmias.
Slovenian: Izkušenj z zdravljenjem z losartanom pri bolnikih s srčnim popuščanjem in sočasno hudo okvaro ledvic, pri bolnikih s hudim srčnim popuščanjem (NYHA razred IV) ter bolnikih s srčnim popuščanjem in simptomatsko življenjsko nevarno srčno aritmijo ni dovolj.
English: Treatment with losartan reduced the risk of stroke by 25 % relative to atenolol (p=0.001 95 % confidence interval 0.63-0.89).
Slovenian: Zdravljenje z losartanom je v primerjavi z atenololom zmanjšalo tveganje za možgansko kap za 25 % (p=0,001;95-odstotni interval zaupanja 0,63-0,89).
English: • if you suffer from excessive vomiting or diarrhoea leading to an extreme loss of fluid and/or salt in your body,
Slovenian: • če močno bruhate ali imate hudo drisko in zato izgubljate veliko tekočine in/ali soli.
English: Galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucosegalactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze-galaktoze tega zdravila ne smejo jemati.
English: Patients with proteinuria and a serum creatinine of 1.3 - 3.0 mg/dl were randomised to receive Losartan 50 mg once a day, titrated if necessary, to achieve blood pressure response, or to placebo, on a background of conventional antihypertensive therapy excluding ACE-inhibitors and angiotensin II antagonists.
Slovenian: Bolnike s proteinurijo in vrednostjo kreatinina v serumu1,3-3,0 mg/dl so randomizirali tako, da so dobivali losartan 50 mg enkrat na dan (po potrebi so odmerek titrirali, da so dosegli odziv krvnega tlaka) ali placebo; poleg tega so bolniki iz obeh skupin dobivali običajna antihipertenzivna zdravila razen zaviralcev ACE in antagonistov angiotenzina II.
English: At the end of three weeks, losartan administration once daily lowered trough blood pressure in a dosedependent manner.
Slovenian: Po treh tednih se je pri uporabi losartana enkrat dnevno krvni tlak v času, ko je učinek zdravila najnižji, zmanjšal v skladu z odmerkom.
English: Losartan may be administered with other blood pressure lowering medicines (e.g. diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents) as well as with insulin and other commonly used medicines that decrease the level of glucose in the blood (e.g. sulfonylureas, glitazones and glucosidase inhibitors).
Slovenian: Losartan se lahko jemlje skupaj z drugimi zdravili za zniževanje krvnega tlaka (npr. diuretiki, zaviralci kalcijevih kanalčkov, alfa ali beta zaviralci in zdravili, ki delujejo na centralno živčevje), kot tudi z insulinom in drugimi običajno uprabljenimi zdravili za zmanjševanje količine glukoze v krvi (npr. sulfonilsečnino, glitazoni, zaviralci glukozidaze).
English: Always take COZAAR exactly as your doctor has instructed you.
Slovenian: Pomembno je, da nadaljujete z jemanjem zdravila COZAAR tako dolgo, kot vam je predpisal zdravnik.
English: Therefore, the plasma concentrations of potassium as well as creatinine clearance values should be closely monitored especially patients with heart failure and a creatinine clearance between 30-50 ml/min should be closely monitored.
Slovenian: Še posebej skrbno je treba spremljati bolnike s srčnim popuščanjem in kreatininskim očistkom 30-50 ml/min.
English: Lindenplatz 1 85540, Haar, Germany
Slovenian: Nemčija VARIPHARM ARZNEIMITTEL GmbH Lindenplatz 1 85540, Haar, Nemčija
English: • In a controlled clinical trial in 9193 hypertensive patients 55 to 80 years of age with left ventricular hypertrophy
Slovenian: • V kontroliranem kliničnem preskušanju pri 9193 hipertenzivnih bolnikih, starih 55 do 80 let, s hipertrofijo levega prekata
English: Use in pediatric patients with renal impairment
Slovenian: Uporaba pri pediatričnih bolnikih z boleznijo ledvic
English: Renal clearance of losartan and its active metabolite is about 74 ml/min and 26 ml/min, respectively.
Slovenian: Renalni očistek losartana je 74 ml/min, njegovega aktivnega presnovka pa 26 ml/min.
English: Pull out the plunger to withdraw the medicine into the syringe.
Slovenian: Izvlecite bat, da potegnete zdravilo v brizgo.
English: Push the plunger of the syringe completely down.
Slovenian: Bat brizge potisnite čisto do konca.