FrancophonIA/ELRC3.0 huggingface dataset:
English: The safety and efficacy of Circadin in children aged 0 to 18 years has not yet been established.
Slovenian: Varnost in učinkovitost zdravila Circadin pri otrocih, starih 0 do 18 let, še nista bili dokazani.
English: Very common (≥1/10); Common (≥1/100 to <1/10); Uncommon (≥1/1,000 to <1/100); Rare (≥1/10,000 to <1/1,000); Very rare (<1/10,000); Not known (cannot be established from the available data).
Slovenian: Zelo pogosti (≥ 1/10); pogosti (≥ 1/100 do <1/10); občasni (≥ 1/1.000 do <1/100); redki (≥ 1/10.000 do <1/1.000); zelo redki (<1/10.000), neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov).
English: It is also associated with a hypnotic effect and increased propensity for sleep.
Slovenian: Povezuje se tudi s hipnotičnimi učinki in povečano nagnjenostjo k spanju.
English: 35039 Marburg
Slovenian: 35039 Marburg Nemčija
English: Do not use this medicine after the expiry date which is stated on the carton (EXP).
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli (EXP).
English: Do not store above 25°C.
Slovenian: Shranjujte pri temperature do 25°C.
English: The study showed that the benefit observed after 3 weeks is maintained for up to 3 months but failed the primary analysis set at 6 months.
Slovenian: Študija je pokazala, da se koristi, opažene po 3 tednih, ohranijo do 3 mesece, vendar pa ni prestala niza primarnih analiz pri 6 mesecih.
English: The combination should be avoided.
Slovenian: Izogibajte se tej kombinaciji.
English: Do not give this medicine to children between the ages of 0 to 18 years as it has not been tested and its effects are unknown.
Slovenian: Ne dajajte tega zdravila otrokom do 18 leta starosti, ker preskusov niso izvedli in učinki niso znani.
English: If you forget to take your tablet, take another as soon as you remember, before going to sleep, or wait until it is time to take your next dose, then go on as before.
Slovenian: Če ste pozabili vzeti tableto, jo vzemite takoj, ko se spomnite, preden greste spat, ali pa počakajte do naslednjega odmerka, nato pa nadaljujte kot običajno.
English: - If you suffer from liver or kidney problems.
Slovenian: • če imate težave z jetri ali ledvicami.
English: The carcinogenicity study in the rat did not reveal any effect which may be relevant for humans.
Slovenian: Študija kancerogenosti pri podganah ni pokazala nikakršnih učinkov, ki bi lahko bili pomembni pri ljudeh.
English: • Loss of consciousness or fainting
Slovenian: • izguba zavesti in omedlevica
English: Bioavailability is in the order of 15%.
Slovenian: Biološka uporabnost je približno 15 %.
English: However, no pharmacodynamic differences between males and females were found despite differences in blood levels.
Slovenian: Vendar pa farmakodinamičnih razlik med moškimi in ženskami kljub različnih ravneh v krvi niso zaznali.
English: • Vertigo (a feeling of dizziness or “spinning”)
Slovenian: • vertigo (občutek omotice ali vrtoglavice)
English: ‘Primary' means that the insomnia does not have any identified cause, including any medical, mental or environmental cause.
Slovenian: »Primarna« pomeni, da vzrok za nespečnost, vključno s karšnim koli medicinskim, duševnim ali okoljskim razlogom, ni pojasnjen.
English: Lancashire BB10 2HW UK
Slovenian: Lancashire BB10 2HW Velika Britanija
English: Frequency not known: (cannot be established from the available data)
Slovenian: Neznana pogostnost: (ni mogoče oceniti iz razpoložljivih podatkov)
English: The absorption of orally ingested melatonin is complete in adults and may be decreased by up to 50% in the elderly.
Slovenian: Absorpcija peroralno zaužitega melatonina pri odraslih je popolna in se lahko zmanjša za do 50 % pri starejših.
English: A slight effect on post-natal growth and viability was found in rats only at very high doses, equivalent to approximately 2000 mg/day in humans.
Slovenian: Rahel učinek na rast in sposobnost preživetja po rojstvu se je pokazal pri podganah samo pri zelo visokih odmerkih, ki ustrezajo približno 2000 mg/dni pri ljudeh.
English: Date of latest renewal: 20 April 2012
Slovenian: Datum prve odobritve: 29. junij 2007 Datum zadnjega podaljšanja: 20. april 2012
English: A 3-4-fold increase in Cmax is apparent for women compared to men.
Slovenian: Pri ženskah je povečanje Cmax 3-4-kratno v primerjavi z moškimi.
English: EU/1/07/392/001 21 tablets EU/1/07/392/002 20 tablets EU/1/07/392/003 30 tablets EU/1/07/392/004 7 tablets
Slovenian: EU/1/07/392/001 21 tablet EU/1/07/392/002 20 tablet EU/1/07/392/003 30 tablet EU/1/07/392/004 7 tablet
English: Do not take Circadin if you are pregnant, think you may be pregnant, trying to become pregnant or breast-feeding.
Slovenian: Ne jemljite zdravila Circadin, če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev.
English: This finding is compatible with the short half-life of melatonin in humans.
Slovenian: Ta ugotovitev je združljiva s kratko razpolovno dobo melatonina pri ljudeh.
English: The blisters are then packed in cardboard boxes.
Slovenian: Pretisni omoti so pakirani v kartonaste škatle.
English: Tablets should be swallowed whole to maintain prolonged release properties.
Slovenian: Tablete je treba pogoltniti cele, da se ohrani njihovo podaljšano sproščanje.
English: If induction occurs, this can give rise to reduced plasma concentrations of concomitantly administered medicinal products.
Slovenian: Če se indukcija pojavi, lahko to privede do znižane plazemske koncentracije zdravil, ki se dajejo sočasno.
English: DATE OF REVISION OF THE TEXT {DD month YYYY}
Slovenian: DATUM ZADNJE REVIZIJE BESEDILA {DD. mesec LLLL}
English: - If you have been told by your doctor that you have an intolerance to some sugars.
Slovenian: • če vam je vaš zdravnik povedal, da ne prenašate nekaterih sladkorjev.
English: − Thioridazine (for the treatment of schizophrenia) and imipramine (for the treatment of depression).
Slovenian: - tioridazin (za zdravljenje shizofrenije) in imipramin (za zdravljenje depresije).
English: Tmax occurs after 3 hours in a fed state.
Slovenian: Tmax se pojavi po 3 urah na poln želodec.
English: Circadin tablets should not be crushed or cut in half.
Slovenian: Tablet Circadin ne drobite in ne režite na pol.
English: The principal metabolite is 6-sulphatoxy-melatonin (6-S-MT), which is inactive.
Slovenian: Najpomembnejši metabolit je 6-sulfatoksimelatonin (6-S-MT), ki ni aktiven.
English: In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between Circadin and zolpidem one hour following co-dosing.
Slovenian: V kliničnem preskušanju so se pokazali jasni znaki prehodnih farmakodinamičnih interakcij med zdravilom Circadin in zolpidemom eno uro po hkratnem dajanju.
English: There is a significant first pass effect with an estimated first pass metabolism of 85%.
Slovenian: Učinek prvega prehoda je pomemben z oceno presnove prvega prehoda 85 %.
English: Older People
Slovenian: Starejši
English: The activity of melatonin at the MT1, MT2 and MT3 receptors is believed to contribute to its sleep-promoting properties, as these receptors (mainly MT1 and MT2) are involved in the regulation of circadian rhythms and sleep regulation.
Slovenian: Predvideva se, da aktivnost melatonina pri receptorjih MT1, MT2 in MT3 prispeva k lastnostim, ki spodbujajo spanje, saj ti receptorji (pretežno MT1 in MT2) sodelujejo pri uravnavanju cirkadianega ritma in uravnavanju spanja.
English: An additional randomised clinical trial (n=600) compared the effects of Circadin and placebo for up to six months.
Slovenian: V dodatnem randomiziranem kliničnem preskušanju (n = 600) so primerjali učinke zdravila Circadin in placeba v obdobju do šest mesecev.
English: • Reduced blood platelets, which increases risk of bleeding or bruising
Slovenian: • zmanjšano število trombocitov, kar povečuje tveganje za pojav krvavitev ali modric
English: The recommended dose is 2 mg once daily, 1-2 hours before bedtime and after food.
Slovenian: Priporočeni odmerek je 2 mg enkrat dnevno, 1-2 uri pred spanjem in po hrani.
English: The use of Circadin is not known to cause any withdrawal effects after treatment completion.
Slovenian: Ni znano, da bi uporaba zdravila Circadin povzročala kakršne koli odtegnitvene učinke po končanju zdravljenja.
English: The study demonstrated improvements in sleep latency, quality of sleep and morning alertness, with no withdrawal symptoms and rebound insomnia.
Slovenian: Študija je pokazala izboljšanje latence spanja, kakovosti spanja in jutranje budnosti brez odtegnitvenih simptomov in povratne nespečnosti.
English: Do not take Circadin - if you are allergic to melatonin or any of the other ingredients of this medicine (listed in section 6).
Slovenian: - če ste alergični na melatonin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Other pharmaceutical forms/strengths may be more appropriate for administration to this population.
Slovenian: Pri tej populaciji je morda primernejša uporaba drugih farmacevtskih oblik/jakosti.
English: Patients with rare hereditary problems of galactose intolerance, the LAPP lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: You should swallow the tablet whole.
Slovenian: Pogoltnite celo tableto.
English: There are data in animal models including rodents, sheep, bovine and primates that indicate maternal transfer of melatonin to the foetus via the placenta or in the milk.
Slovenian: Obstajajo podatki iz živalskih modelov, vključno z glodavci, ovcami, govedom in primati, ki nakazujejo prenos melatonina na zarodek preko placente ali v mleko.
English: Therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Slovenian: Zato je treba zdravilo jemati previdno, če so učinki zaspanosti povezani s tveganjem za varnost.
English: The in vitro plasma protein binding of melatonin is approximately 60%.
Slovenian: In vitro vezava melatonina na proteine plazme je približno 60 %.
English: At 3 months, about an extra 10% of responders were seen in the Circadin treated group.
Slovenian: Pri 3 mesecih so v skupini, zdravljeni z zdravilom Circadin opazili dodatnih približno 10 % oseb, ki se je odzivalo.
English: The kinetics of melatonin are linear over the range of 2-8 mg.
Slovenian: Kinetika melatonina je linearna v razponu med 2-8 mg.
English: France e-mail: regulatory@neurim.com
Slovenian: Francija e-pošta: regulatory@neurim.com
English: Because of the role of melatonin in sleep and circadian rhythm regulation, and the age related decrease in endogenous melatonin production, melatonin may effectively improve sleep quality particularly in patients who are over 55 with primary insomnia.
Slovenian: Zaradi vloge melatonina pri uravnavanju spanja in cirkadianega ritma in s starostjo povezanim zmanjšanjem proizvodnje endogenega melatonina, lahko melatonin učinkovito izboljša kakovost spanja, še zlasti pri bolnikih s primarno nespečnostjo, starih več kot 55 let.
English: If you stop taking Circadin
Slovenian: Če ste prenehali jemati Circadin
English: In addition, there were fewer dropouts in the active treatment group (9 patients; 15.0%) compared to the placebo group (21 patients; 32.3%).
Slovenian: Tudi upad udeležencev je bil v skupini zdravljenja z učinkovino manjši (9 bolnikov; 15,0 %) v primerjavi s skupino s placebom (21 bolnikov; 32,3 %).
English: Circadin shortened patients' reported sleep latency by 24.3 minutes vs 12.9 minutes with placebo.
Slovenian: Bolniki, ki so jim zmanjšali odmerek zdravila Circadin, so poročali o latentnosti uspavanja 24,3 minute v primerjavi z 12,9 minutami s placebom.
English: Pharmacotherapeutic group: Psycholeptics, melatonin receptor agonists, ATC code: N05CH01
Slovenian: Farmakoterapevtska skupina: psiholeptiki, agonisti receptorjev melatonina, oznaka ATC: N05CH01
English: Another medicine containing melatonin may be more appropriate for administration to children between the ages of 2 to 18 - please ask your doctor or pharmacist for advice.
Slovenian: Pri otrocih, starih od 2 do 18 let, je morda primernejša uporaba drugega zdravila, ki vsebuje melatonin - posvetujte se z zdravnikom ali farmacevtom.
English: For melatonin, no clinical data on exposed pregnancies are available.
Slovenian: Za melatonin ni na voljo kliničnih podatkov od nosečnic, ki so bile izpostavljene zdravilu.
English: Do not drink alcohol before, during or after taking Circadin, because it reduces the effectiveness of Circadin.
Slovenian: Pred, med ali po jemanju zdravila Circadin ne pijte alkohola, ker ta zmanjšuje učinkovitost zdravila Circadin.
English: Concomitant administration resulted in increased impairment of attention, memory and co-ordination compared to zolpidem alone.
Slovenian: Hkratno dajanje je vplivalo na poslabšanje pozornosti, spominskih funkcij in koordinacije v primerjavi z dajanjem samega zolpidema.
English: SPECIAL STORAGE CONDITIONS Do not store above 25ºC.
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi do 25ºC.
English: Elimination is by renal excretion of metabolites, 89% as sulphated and glucoronide conjugates of 6-hydroxymelatonin and 2% is excreted as melatonin (unchanged active substance).
Slovenian: Izločanje poteka z izločanjem metabolitov skozi ledvice, 89 % kot sulfatni in glukoronidni konjugati 6-hidroksimelatonina in 2 % se izloča kot melatonin (nespremenjena zdravilna učinkovina).
English: Company data indicates that there is no accumulation of melatonin after repeated dosing.
Slovenian: Podatki družbe kažejo, da se melatonin ne akumulira s ponavljajočimi odmerki.
English: • Cigarette smoking may decrease melatonin levels due to induction of CYP1A2.
Slovenian: • Kajenje cigaret lahko zniža ravni melatonina zaradi indukcije CYP1A2.
English: Sleep variables gradually returned to baseline with no rebound, no increase in adverse reactions and no increase in withdrawal symptoms.
Slovenian: Spremenljivke spanja so se postopoma vrnile k izhodišču brez povratnega učinka (rebound), povečanih neželenih učinkov in brez povečanih odtegnitvenih simptomov.
English: The tablets are packed in PVC/PVDC opaque blister strips with aluminium foil backing.
Slovenian: Tablete so pakirane v neprozorne pretisne omote PVC/PVDC s hrbtno stranjo iz aluminija.
English: Plasma melatonin levels in patients with cirrhosis were significantly increased during daylight hours.
Slovenian: Ravni melatonina v plazmi pri bolnikih s cirozo so bile v svetlih urah dneva znatno povečane.
English: • Reduced number of white blood cells in the blood
Slovenian: • zmanjšano število levkocitov v krvi
English: Other medicines and Circadin
Slovenian: Druga zdravila in zdravilo Circadin
English: Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle.
Slovenian: Melatonin povezujejo z nadzorom cirkadianega ritma in uvajanjem v cikel svetlobe in teme.
English: Taking more than the recommended daily dose may make you feel drowsy.
Slovenian: Zaradi dnevnega odmerka, večjega od priporočenega, boste morda zaspani.
English: However, Circadin co-administration resulted in increased feelings of tranquility and difficulty in performing tasks compared to imipramine alone, and increased feelings of “muzzyheadedness” compared to thioridazine alone.
Slovenian: Vendar pa je povzročilo hkratno dajanje zdravila Circadin povečan občutek mirnosti in težave pri izvajanju nalog v primerjavi z dajanjem samega imipramina, ter povečan občutek „topoglavosti“ v primerjavi s samim tioridazinom.
English: Frosst Ibérica, S.A. Vía Complutense, 140 Alcalá de Henares 28805 Madrid Spain
Slovenian: Vía Complutense, 140 Alcalá de Henares 28805 Madrid
English: The levels assessed in the blood of the patients at 23:00 (2 hours after administration) following 1 and 3 weeks of daily administration were 411.4 ± 56.5 and 432.00 ± 83.2 pg/ml respectively, and are similar to those found in in healthy volunteers following a single dose of Circadin 2 mg.
Slovenian: Ravni, izmerjene v krvi bolnikov ob 23:00 (2 uri po zaužitju) po 1 in 3 tednih vsakodnevnega jemanja so bile 411,4 ± 56,5 oziroma 432,00 ± 83,2 pg/ml in so bile podobne tistim, ki so jih izmerili pri zdravih prostovoljcih po enojnem odmerku zdravila Circadin 2 mg.
English: In clinical trials a total of 9.5% of patients receiving Circadin reported an adverse reaction compared with 7.4% of patients taking placebo.
Slovenian: V kliničnih preskušanjih je skupno 9,5 % bolnikov, ki so prejemali zdravilo Circadin, poročalo o neželenih učinkih, v primerjavi s 7,4 % bolnikov, ki so prejemali placebo.
English: The effect of any stage of renal impairment on melatonin pharmacokinetics has not been studied.
Slovenian: Učinkov ledvične okvare katere koli stopnje na farmakokinetiko melatonina niso raziskovali.
English: Nervous system disorders were more common in the active group with 42% patients, compared to 23% in the placebo group, mainly driven by somnolence and headache more frequent in the active group.
Slovenian: Motnje živčnega sistema so bile pogostejše v skupini z učinkovino, in sicer pri 42 % bolnikov, v primerjavi s 23 % v skupini s placebom, predvsem zaradi zaspanosti in glavobola, ki sta bila bolj pogosta v skupini z učinkovino.
English: Whether or not these active substances interfere with the dynamic or kinetic effects of Circadin or vice versa has not been studied.
Slovenian: Niso preučevali ali te zdravilne učinkovine vplivajo na dinamične ali kinetične učinke zdravila Circadin ali obratno.
English: Circadin has moderate influence on the ability to drive and use machines.
Slovenian: Zdravilo Circadin ima blag ali zmeren vpliv na sposobnost vožnje in upravljanja s stroji.
English: Published data demonstrates markedly elevated endogenous melatonin levels during daytime hours due to decreased clearance in patients with hepatic impairment.
Slovenian: Objavljeni podatki kažejo na znatno povišane ravni endogenega melatonina podnevi zaradi zmanjšanega očistka pri bolnikih z okvaro jeter.
English: The excretion of the metabolite is completed within 12 hours after ingestion.
Slovenian: Izločanje metabolita je zaključeno v 12 urah po zaužitju.
English: There were no modifications of sleep architecture and no effect on REM sleep duration by Circadin.
Slovenian: Sprememb v arhitekturi spanja in učinkov na trajanje spanja REM pri jemanju zdravila Circadin niso opazili.
English: If you experience any of the following serious side effects, stop taking the medicine and contact your doctor immediately:
Slovenian: Če opazite katerega koli od naslednjih resnih neželenih učinkov, prenehajte jemati to zdravilo in se takoj posvetujte z zdravnikom:
English: - Smoking may make Circadin less effective, because the components of tobacco smoke can increase the breakdown of melatonin by the liver.
Slovenian: • kajenje lahko zmanjša učinkovitost zdravila Circadin, ker sestavine tobačnega dima lahko povečajo razgradnjo melatonina v jetrih.
English: Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night.
Slovenian: Fiziološko se pojavi izločanje melatonina takoj, ko se začne temniti, in doseže vrhunec med 2-4 uro zjutraj, v drugi polovici noči pa se količina manjša.
English: No clinically significant pharmacokinetic interactions were found in each case.
Slovenian: V nobenem primeru niso ugotovili klinično pomembnih farmakokinetičnih interakcij.
English: Hypersensitivity reaction, swelling of mouth or tongue, swelling of the skin and abnormal milk secretion.
Slovenian: Preobčutljivnostne reakcije, oteklost ust ali jezika, oteklost kože in nenormalno izločanje mleka.
English: In clinical trials (in which a total of 1,931 patients were taking Circadin and 1,642 patients were taking placebo), 48.8% of patients receiving Circadin reported an adverse reaction compared with 37.8% taking placebo.
Slovenian: V kliničnih preskušanjih (v katerih je skupno 1931 bolnikov jemalo zdravilo Circadin in 1642 bolnikov placebo) je 48,8 % bolnikov, ki so prejemali zdravilo Circadin, poročalo o neželenih učinkih v primerjavi s 37,8 %, ki so jemali placebo.
English: Circadin is mainly bound to albumin, alpha1-acid glycoprotein and high density lipoprotein.
Slovenian: Zdravilo Circadin se veže pretežno na albumin, alfa1 kisli glikoprotein in lipoprotein visoke gostote.
English: Crushing or chewing should not be used to facilitate swallowing.
Slovenian: Ne sme se jih drobiti ali žvečiti zaradi lažjega požiranja.
English: • Circadin may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics, such as zaleplon, zolpidem and zopiclone.
Slovenian: • Zdravilo Circadin lahko poveča pomirjevalne lastnosti benzodiazepinskih in ne-benzodiazepinskih hipnotikov kot so zaleplon, zolpidem in zopiklon.
English: Comparing the rate of patients with adverse reactions per 100 patient weeks, the rate was higher for placebo than Circadin (5.743- placebo vs. 3.013- Circadin).
Slovenian: Pri primerjavi razmerja bolnikov z neželenimi učinki s 100 tedni zdravljenja je bila stopnja za placebo višja od stopnje za zdravilo Circadin (5,743placebo v primerjavi s 3,013 - zdravilo Circadin).
English: If you experience any of the following non-serious side effects contact your doctor and/or seek medical advice:
Slovenian: Če opazite katerega koli od naslednjih neželenih učinkov, ki niso resni, se posvetujte z zdravnikom in/ali poiščite zdravniški nasvet:
English: The pack consists of one blister strip containing 7, 20 or 21 tablets, or two blister strips containing 15 tablets each (30 tablets).
Slovenian: Pakiranje vsebuje en pretisni omot z 7, 20 ali 21 tabletami ali dva dvojna traka, ki vsebujeta po 15 tablet (30 tablet).
English: Circadin may cause drowsiness, therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Slovenian: Zdravilo Circadin lahko povzroči zaspanost, zato je treba zdravilo jemati previdno, če so učinki zaspanosti povezani s tveganjem za varnost.
English: Several cases of overdose have been reported post-marketing.
Slovenian: V obdobju trženja so poročali o nekaj primerih prevelikega odmerjanja.
English: The presence of food delayed the absorption of the melatonin resulting in a later (Tmax=3.0 h versus Tmax=0.75 h) and lower peak plasma concentration in the fed state (Cmax=1020pg/ml versus Cmax=1176 pg/ml).
Slovenian: Prisotnost hrane upočasni absorpcijo melatonina, kar povzroči kasnejši (Tmax = 3,0 h v primerjavi s Tmax = 0,75 h) in nižji vrh plazemske koncentracije v stanju na poln želodec (Cmax = 1020 pg/ml v primerjavi s Cmax = 1176 pg/ml).
English: The most common adverse reactions were headache, nasopharyngitis, back pain, and arthralgia, which were common, by MedDRA definition, in both the Circadin and placebo treated groups.
Slovenian: Najpogostejši neželeni učinki so bili glavobol, nazofaringitis, bolečine v hrbtu in artralgija, ki so bili, po opredelitvi MedDRA, pogosti v obeh skupinah, v skupini, ki je prejemala zdravilo Circadin in v skupini, ki je prejemala placebo.
English: White to off-white, round, biconvex tablets
Slovenian: Bele do umazano bele, okrogle, bikonveksne tablete.
English: This leaflet was last revised in { month/YYYY}.
Slovenian: Navodilo je bilo nazadnje revidirano dne (MM/LLLL)
English: The recommended dose is one Circadin tablet (2 mg) taken daily by mouth, after food, 1-2 hours before bedtime.
Slovenian: Priporočeni odmerek je ena tableta zdravila Circadin (2 mg) dnevno, zaužita peroralno, po obroku, 1-2 uri pred spanjem.
English: Caution should be used when melatonin is administered to such patients.
Slovenian: Pri dajanju melatonina takim bolnikom je potrebna previdnost.
English: • Alcohol should not be taken with Circadin, because it reduces the effectiveness of Circadin on sleep.
Slovenian: • Z zdravilom Circadin naj ne bi uživali alkohola, saj slednji zmanjša učinkovitost zdravila Circadin na spanje.
English: Visual acuity reduced, vision blurred, lacrimation increased
Slovenian: Očesne bolezni zmanjšana ostrina vida, zamegljen vid, povečano izločanje solz