FrancophonIA/ELRC3.0 huggingface dataset:
English: The most commonly used dosage regimen (1 g every 12 hours) was considered adequate by the CHMP from a pharmacokinetic and pharmacodynamic perspective for the majority of patients with normal renal function and based on the usual susceptibility of staphylococci (minimum inhibitory concentration (MIC) ≤1 mg/L).
Croatian: S farmakokinetičkog i farmakodinamičkog stajališta i na temelju uobičajene osjetljivosti stafilokoka (minimalna inhibitorna koncentracija (MIC) ≤1 mg/L), CHMP smatra primjerenim najčešće upotrebljavani režim doziranja (1 g svakih 12 sati) za većinu bolesnika s normalnom funkcijom bubrega.
English: The guidance provides treatment recommendations for initial and recurrent CDI.
Croatian: U smjernicama se pružaju preporuke za liječenje početne i ponovljene infekcije bakterijom Clostridium difficile.
English: will enter into force, the limits of the impurities in the drug substance and final drug products will need to be revised accordingly, where applicable.
Croatian: Kad monografija vankomicina u Europskoj farmakopeji stupi na snagu, ograničenja nečistoća u djelatnoj tvari lijeka i konačnom lijeku trebat će, po potrebi, revidirati u skladu s tim.
English: Date of first authorisation: 11/02/2014
Croatian: Datum prvog odobrenja: 11/02/2014
English: Do not allow recently treated animals to groom each other.
Croatian: Ne dozvoliti da nedavno tretirane životinje dodiruju jedna drugu.
English: The expiry date refers to the last day of that month.
Croatian: Rok valjanosti se odnosi na zadnji dan u tom mjesecu.
English: It takes up to 48 hours for the application site to become dry but it will be noticeable for longer.
Croatian: Potrebno je do 48 sati da bi se mjesto aplikacije osušilo, a bit će vidljivo još neko vrijeme.
English: Do not eat, drink or smoke while handling the product.
Croatian: Ne jesti, piti ili pušiti prilikom rukovanja proizvodom.
English: Food enhances the absorption.
Croatian: Hrana povećava apsorbciju.
English: This includes cuddling the animal and sharing a bed with the animal.
Croatian: Ovo uključuje maženje životinje i dijeljenje istog kreveta.
English: A used pipette should immediately be disposed of.
Croatian: Upotrijebljenu pipetu treba odmah ukloniti.
English: If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth.
Croatian: Ako pas dobrovoljno ne uzme tabletu može se također dati putem hrane ili direktno u usta.
English: Use only accordingly to the benefit/risk assessment by the responsible veterinarian.
Croatian: Koristiti samo u skladu s procjenom koristi/rizika od strane nadležnog veterinara.
English: 1210 Vienna
Croatian: 1210 Beč
English: This product can cause eye irritation.
Croatian: Proizvod uzrokuje iritaciju oka.
English: See section 4.2.
Croatian: Vidi odlomak 4.2.
English: Use with caution in dogs with pre-existing epilepsy.
Croatian: Upotrebljavati s oprezom kod pasa s već postojećom epilepsijom.
English: Read package leaflet for full user safety information.
Croatian: Pročitati uputu za potpune sigurnosne informacije.
English: Keep away from heat, sparks, open flame or other sources of ignition.
Croatian: Držati dalje od izvora topline, iskre, otvorenog plamena ili drugih zapaljivih izvora.
English: Care should be taken to avoid contact with the eyes of the animal.
Croatian: Paziti da se izbjegne kontakt s očima životinje.
English: The chewable tablets should not be broken or divided.
Croatian: Tablete za žvakanje ne smiju biti polomljene ili podijeljene.
English: No treatment-related clinical signs were observed.
Croatian: Klinički znaci povezani s tretmanom nisu uočeni.
English: Keep the pipette in the sachet until use.
Croatian: Čuvajte pipetu u vrećici do primjene.
English: Dimethylacetamide Glycofurol
Croatian: Dimetilacetamid Glikofurol
English: See section 4.
Croatian: Vidi odlomak 4.
English: Diethyltoluamide (DEET) Acetone
Croatian: Dietiltoluamid (DEET) Aceton
English: Step 1: Immediately before use, open the sachet and remove the pipette.
Croatian: Korak 1: Neposredno prije primjene, otvoriti vrećicu i odvojiti pipetu.
English: Do not wash or allow the dog to become immersed in water or swim in water courses within 3 days after treatment.
Croatian: Ne kupajte psa i ne dozvolite da bude uronjen u vodu ili pliva unutar 3 tjedna nakon tretiranja.
English: Each carton box contains 1 or 2 pipettes.
Croatian: Svaka kartonska kutija sadrži 1 ili 2 pipete.
English: Hypersensitivity reactions in humans have been reported.
Croatian: Prijavljene su reakcije preosjetljivosti kod ljudi.
English: Bravecto is a chewable tablet and is well accepted by most dogs.
Croatian: Bravecto je tableta za žvakanje i većinom je psi dobro prihvaćaju.
English: Do not use directly on skin lesions.
Croatian: Ne koristite direktno na ozlijeđenoj koži.
English: The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Croatian: Proizvod se može koristiti kao dio strategije liječenja u kontroli alergijskog dermatitisa uzrokovanog buhama (FAD).
English: Lot:{number}
Croatian: Lot: {broj}
English: Major incompatibilities: None known.
Croatian: Glavne inkompatibilnosti: Nisu poznate.
English: Intervet Productions Rue de Lyons 27460 Igoville FRANCE
Croatian: Otopina za nakapavanje: Intervet Productions Rue de Lyons 27460 Igoville FRANCUSKA
English: In case of spillage onto, for example table or floor surfaces, remove excess product using paper tissue and clean the area with detergent.
Croatian: U slučaju prolijevanja na, npr. stol ili pod, odstraniti višak proizvoda upotrebljavajući papirnate maramice te očistiti površinu sredstvom za pranje.
English: Light to dark brown tablet with a smooth or slightly rough surface and circular shape.
Croatian: Tableta svijetlo do tamno smeđe boje glatke ili neznatno grube površine i okruglog oblika.
English: In some cases, soap and water is not sufficient to remove the product spilled on the fingers, therefore gloves must be used.
Croatian: U nekim slučajevima, sapun i voda nisu dovoljni da bi se isprao proizvod stoga treba nositi zaštitne rukavice.
English: In case of contact with the eyes, immediately rinse thoroughly with water.
Croatian: U slučaju kontakta s očima, odmah isprati čistom vodom.
English: Contact may occur either directly, when handling the product, or when handling the treated animal.
Croatian: Kontakt se može desiti direktno, primjenom proizvoda ili diranja tretirane životinje.
English: The product binds to skin and may also bind to surfaces after spillage of the product.
Croatian: Proizvod se lijepi za kožu i može se vezati za površine nakon prolijevanja.
English: Renal clearance is the minor route of elimination.
Croatian: Bubrežno izlučivanje je manji put eliminacije.
English: Make sure that your animal's application site is no longer noticeable before resuming contact with the site of application.
Croatian: Osigurajte da mjesto aplikacije više nije vidljivo prije daljnjeg kontakta s istim mjestom.
English: Sodium lauryl sulfate Disodium embonate monohydrate Magnesium stearate Aspartame
Croatian: Natrijev lauril sulfat Dinatrijev embonat monohidrat Magnezijev stearat Aspartam
English: Incubation of fluralaner in the presence of carprofen or warfarin in dog plasma at maximum expected plasma concentrations did not reduce the protein binding of fluralaner, carprofen or warfarin.
Croatian: Inkubacija fluralanera u prisutnosti karprofena ili varfarina u plazmi pasa na maksimalno očekivanoj koncentraciji plazme nije umanjila proteinsko vezanje fluralanera, karprofena ili varfarina.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Blister
Croatian: PODACI KOJI SE MORAJU NALAZITI NA BLISTERIMA ILI TRAKAMA
English: Step 2: The cat should be standing or lying with its back horizontal for easy application.
Croatian: Korak 2: Mačka treba stajati ili ležati s leđima u horizontalnom položaju za lakšu primjenu.
English: For optimal control of tick infestation, the timing of retreatment depends on the tick species.
Croatian: Za optimalnu kontrolu infestacije krpeljima, vrijeme ponovnog liječenja ovisi o vrsti krpelja.
English: Intervet UK Limited Walton Manor, Walton, Milton Keynes, Buckinghamshire, MK7 7AJ UNITED KINGDOM
Croatian: Intervet UK limited Walton Manor, Walton, Milton Keynes, Buckinghamshire, MK7 7AJ Ujedinjeno Kraljevstvo
English: Step 2: The dog should be standing or lying with its back horizontal during application.
Croatian: Korak 2: Pas treba stajati ili ležati s leđima u horizontalnom položaju tijekom primjene.
English: The product should be applied on cats up to 6.25 kg body weight in one spot at the base of the skull and in two spots on cats greater than 6.25 kg bodyweight.
Croatian: Proizvod treba aplicirati na mačku do 6,25 kg tjelesne mase na jedno mjesto na stražnji dio glave i na dva mjesta ako je mačka teža od 6,25 kg tjelesne mase.
English: The pipette is open and ready for application when the breaking of the seal is felt.
Croatian: Pipeta je otvorena i spremna za primjenu kada primijetite pucanje folije.
English: The dog should be observed during administration to confirm that the tablet is swallowed.
Croatian: Prilikom primjene treba promatrati psa da bismo bili sigurni da je tableta progutana.
English: A plateau is seen in plasma between 7 and 63 days post administration, after which concentrations decline slowly.
Croatian: Najveća koncentracija je uočena u plazmi između 7 i 63 dana nakon aplikacije nakon čega polako opada.
English: Fluralaner has a high potency against ticks and fleas by exposure via feeding, i.e. it is systemically active on target parasites.
Croatian: Fluralaner ima visoku potentnost protiv krpelja i buha, izloženih putem hranjenja, npr. sustavno je aktivan u ciljnih parazita.
English: The sachets should only be opened immediately prior to use.
Croatian: Vrećice treba otvarati samo neposredno prije upotrebe.
English: Convulsions and lethargy has been reported very rarely in spontaneous (pharmacovigilance) reports.
Croatian: Vrlo rijetko su prijavljene letargija i konvulzije u spontanim (farmakovigilancijskim) izvješćima.
English: In molecular on-target studies on insect GABA receptors of flea and fly, fluralaner is not affected by dieldrin resistance.
Croatian: U molekularnim ispitivanjima ciljanim na GABA receptore buha i muha, dieldrinska rezistencija ne utječe na fluralaner.
English: Keep the product in the original packaging until use, in order to prevent children from getting direct access to the product.
Croatian: Čuvati proizvod u originalnom pakiranju do upotrebe, kako bi djeci onemogućili direktan pristup proizvodu.
English: Each ml contains 280 mg fluralaner.
Croatian: Svaki ml sadrži 280 mg fluralanera.
English: People with a sensitive skin or known allergy in general e.g. to other veterinary medicinal products of this type should handle the veterinary medicinal product as well as treated animals with caution.
Croatian: Ljudi s osjetljivom kožom ili poznatom alergijom, općenito trebaju oprezno upotrebljavati veterinarsko-medicinske proizvode ovog tipa te oprezno rukovati s tretiranim životinjama.
English: For optimal control of tick and flea infestation, the product should be administered at intervals of 12 weeks.
Croatian: Za optimalnu kontrolu infestacije buhama i krpeljima, proizvod treba primjenjivati u intervalima od 12 tjedana.
English: Convulsions and lethargy has been reported very rarely in spontaneous reports.
Croatian: Vrlo rijetko su prijavljene letargija i konvulzije u spontanim izvješćima.
English: The cap will stay on the pipette; it is not possible to remove it.
Croatian: Zatvarač će ostati na pipeti, nije ga moguće odvojiti.
English: The prolonged persistence and slow elimination from plasma (t1/2 = 12 days) and the lack of extensive metabolism provide effective concentrations of fluralaner for the duration of the inter-dosing interval.
Croatian: Produžena perzistentnost i spora eliminacija iz plazme (t1/2 = 12 dana) i nedostatak ekstenzivnog metabolizma osigurava učinkovitu koncentraciju fluralanera između 2 intervala doziranja.
English: Parasites need to start feeding on the host to become exposed to fluralaner; therefore the risk of the transmission of parasite borne diseases cannot be excluded.
Croatian: Paraziti se moraju početi hraniti na domaćinu kako bi bili izloženi fluralaneru; stoga se ne može isključiti rizik prijenosa bolesti prenosivih parazitima.
English: Each pipette delivers:
Croatian: Svaka pipeta sadržava:
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Carton Box
Croatian: PODACI NA VANJSKOM PAKOVANJU Kartonska kutija
English: Intervet GesmbH Siemensstrasse 107 1210 Vienna AUSTRIA
Croatian: Tablete za žvakanje: Intervet GesmbH Siemensstrasse 107 1210 Beč
English: Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance.
Croatian: Krpelji i buhe moraju se prihvatiti na domaćina i započeti hranjenje kako bi bili izloženi djelatnoj tvari.
English: Clear colourless to yellow solution.
Croatian: Bezbojna do žućkasta otopina.
English: Fluralaner is systemically distributed and reaches the highest concentrations in fat, followed by liver, kidney and muscle.
Croatian: Fluralaner je sustavno raspoređen te svoju najveću koncentraciju postiže u masnom tkivu, nakon čega slijede jetra, bubrezi i mišići.
English: The flea life cycle is broken due to the rapid onset of action and long lasting efficacy against adult fleas on the animal and the absence of viable egg production.
Croatian: Životni ciklus buha prekinut je uslijed trenutnog i dugotrajnog učinka protiv odraslih buha na životinjama te nemogućnosti proizvodnje održivih jajašaca.
English: Apply to skin.
Croatian: Za nakapavanje na kožu.
English: For optimal control of flea infestation, the veterinary medicinal product should be administered at intervals of 12 weeks.
Croatian: Za optimalnu kontrolu infestacije buhama, veterinarsko-medicinski proizvod treba primjenjivati u intervalima od 12 tjedana.
English: An in vitro study also demonstrated that very low concentrations of fluralaner stop the production of viable eggs by fleas.
Croatian: In vitro ispitivanja također su pokazala da je mala koncentracija fluralanera zaustavila proizvodnju održivih jajašca buha.
English: Bodyweight of dog (kg)
Croatian: Tjelesna težina pasa (kg)
English: Wear gloves when handling and administering this product.
Croatian: Nositi zaštitne rukavice prilikom rukovanja i primjene ovog proizvoda.
English: Fluralaner is readily systemically absorbed from the topical administration site, reaching maximum concentrations in plasma between 3 and 21 days after administration.
Croatian: Fluralaner je odmah apsorbiran nakon primjene na mjesto za nakapavanje, a doseže maksimum koncentracije u plazmi između 3 i 21 dan nakon primjene.
English: The product should not be used by persons with a hypersensitivity to the active substance or to any of the excipients (see contraindications, section 4.3).
Croatian: Proizvod ne smiju upotrebljavati osobe preosjetljive na djelatnu tvar ili bilo koju od pomoćnih tvari (vidjeti pod kontraindikacije, odjeljak 4.3 ).
English: Interaction with other medicinal products and other forms of interaction: None known.
Croatian: Interakcije s drugim medicinskim proizvodima ili drugi oblici interakcije Nisu poznate.
English: Manufacturer responsible for batch release: Intervet GesmbH
Croatian: Proizvođač odgovoran za puštanje serije u promet: Intervet GesmbH
English: Step 3: Squeeze the pipette gently and apply the entire contents directly to the cat's skin.
Croatian: Korak 3: Nježno istisnite pipetu i aplicirajte cijelu količinu direktno na ili na kožu mačke.
English: and Rhipicephalus sanguineus) and fleas (Ctenocephalides spp.)
Croatian: Rhipicephalus sanguineus) i buha (Ctenocephalides spp.) na psima.
English: Some marbling, speckles or both may be visible.
Croatian: Poneka mrlja ili pjega mogu biti uočljive.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Active substance:
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV DJELATNIH TVARI
English: Treatment schedule:
Croatian: Raspored liječenja:
English: Bodyweight of cat (kg)
Croatian: Tjelesna težina mačaka (kg)
English: Soya-bean oil
Croatian: Sojino ulje
English: The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Croatian: U priloženoj uputi veterinarsko medicinskog proizvoda treba biti navedeno ime i adresa proizvođača odgovornog za puštanje serije u promet.
English: Place the pipette tip vertically against the skin between the shoulder blades of the dog.
Croatian: Stavite vrh pipete okomito na kožu između lopatica psa.
English: Pharmacotherapeutic group: Ectoparasiticides for systemic use ATCvet code: QP53B E02
Croatian: Farmakoterapijska grupa: ektoparaziticidi za sustavnu upotrebu ATCvet kod: QP53BE02
English: The following other signs shortly after administration were uncommonly observed: apathy/tremors/anorexia (0.9% of treated cats) or vomiting/hypersalivation (0.4% of treated cats).
Croatian: Nakon primjene manje često su uočene sljedeće nuspojave: apatija/tremor/anoreksija (0,9% tretiranih mačaka) ili povraćanje/pojačano slinjenje (0,4% tretiranih mačaka).
English: Following oral administration, fluralaner is readily absorbed reaching maximum plasma concentrations within 1 day.
Croatian: Sljedeći peroralnu primjenu, fluralaner je odmah apsorbiran i postiže maksimalnu koncentraciju u plazmi unutar jednog dana.
English: Manufacturer responsible for batch release: Intervet Productions
Croatian: Proizvođač odgovoran za puštanje serije u promet: Intervet Productions
English: Fluralaner is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate-receptor).
Croatian: Fluralaner je jak inhibitor dijelova živčanog sustava artropoda koji djeluje antagonistički na ligandom regulirane kloridne kanale (GABA-receptori i glutamat receptori).
English: In in vitro bio-assays, fluralaner is not affected by proven field resistances against amidines (tick), organophosphates (tick, mite), cyclodienes (tick, flea, fly), macrocyclic lactones (sea lice), phenylpyrazoles (tick, flea), benzophenyl ureas (tick), pyrethroids (tick, mite) and carbamates (mite).
Croatian: U in-vitro bio-testovima, fluralaner nije bio zahvaćen dokazanom terenskom rezistencijom protiv amidina (krpelji), organofosfata (krpelj, grinje), ciklodina (krpelj, buha, muha), makrocikličkih laktona (morske uši), fenilpirazola (krpelj, buha), benzofenil uree (krpelj), piretroida (krpelj, grinje) i karbamata (grinje).
English: Cardboard box with 1 aluminium foil blister sealed with PET aluminium foil lid stock containing 1, 2 or 4 chewable tablets.
Croatian: Kartonska kutija s 1 aluminijskim blisterom, zapečaćenim PET aluminijskom folijom koji sadrži 1, 2 ili 4 tablete za žvakanje.
English: Do not use this veterinary medicinal product after the expiry date stated on the packaging after EXP.
Croatian: Ne primjenjivati veterinarsko-medicinski proizvod nakon isteka roka valjanosti koji je naznačen na pakovanju nakon oznake EXP.
English: Newly emerged fleas on a dog are killed before viable eggs are produced.
Croatian: Tek izlegnute buhe na psu ubijene su prije nego što su uspjele proizvesti održiva jajašca.
English: Treatment schedule
Croatian: Raspored tretmana
English: Fluralaner is readily absorbed from the topical administration site into the hair, skin and subjacent tissues, from where it is slowly absorbed into the vascular system.
Croatian: Sljedeći primjenu na koži, fluralaner je odmah apsorbiran u dlaci, koži i okolnim tkivima odakle je polako apsorbiran u krvni sustav.
English: Newly emerged fleas on a cat are killed before viable eggs are produced.
Croatian: Tek izlegnute buhe na mački ubijene su prije nego što su uspjele proizvesti održiva jajašca.
English: Oral uptake of the product at the maximum recommended dose of 93 mg fluralaner/kg body weight was well tolerated in cats, apart from some self-limiting salivation and coughing or vomiting immediately after administration.
Croatian: Peroralnu upotrebu maksimalne doze od 93 mg fluralanera/kg tjelesne težine mačke dobro podnose, osim povećanog slinjenja i kašlja ili povraćanja odmah nakon uzimanja.
English: Step 3: Squeeze the pipette gently and apply the entire contents directly to the dog's skin in one (when volume is small) or several spots along the dog's dorsal line from the shoulder to the base of the tail.
Croatian: Korak 3: Nježno istisnite pipetu i aplicirajte cijelu količinu direktno na jedno (kod manjih sadržaja) ili na nekoliko mjesta duž leđne linije od lopatice do vrha repa.
English: Fluralaner is highly bound to plasma proteins and might compete with other highly bound active substances such as non-steroidal anti-inflammatory drugs (NSAIDs) and the coumarin derivative warfarin.
Croatian: Fluralaner se čvrsto veže za proteine plazme te može konkurirati ostalim čvrsto vezujućim djelatnim tvarima poput nesteroidnih protuupalnih lijekova (NSPUL) i kumarinskog derivata varfarina.
English: This product is for topical use and should not be administered orally.
Croatian: Proizvod je namijenjen za primjenu na koži i ne smije se davati peroralno.
English: If skin reactions occur, consult a physician and show them the product packaging.
Croatian: Ukoliko dođe do kožnih reakcija, posavjetujte se s liječnikom i pokažite mu uputu.
English: In case of accidental ingestion, seek medical advice and show the package leaflet or the label to the physician.
Croatian: U slučaju nehotičnog gutanja potražiti stručni savjet te liječniku pokazati uputu ili naljepnicu.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Croatian: Učestalost nuspojava je određena sukladno sljedećim pravilima: - vrlo česte (više od 1 na 10 tretiranih životinja pokazuju nuspojave) - česte (više od 1 ali manje od 10 životinja na 100 tretiranih životinja) - manje česte (više od 1 ali manje od 10 životinja na 1.000 tretiranih životinja) - rijetke (više od 1 ali manje od 10 životinja na 10.000 tretiranih životinja) - vrlo rijetke (manje od 1 životinje na 10.000 tretiranih životinja, uključujući izolirane slučajeve).
English: EXP: {month/year}
Croatian: ROK VALJANOSTI EXP {mjesec/godina}
English: Put on gloves.
Croatian: Staviti rukavice.
English: 0.4 ml 0.89 ml 1.79 ml
Croatian: 0,89 ml 1,79 ml
English: The product should not be used by persons with a hypersensitivity to the active substance or to any of the excipients (see section Contraindications).
Croatian: Proizvod ne smiju upotrebljavati osobe preosjetljive na djelatnu tvar ili bilo koju od pomoćnih tvari (vidjeti odjeljak Kontraindikacije)
English: Wash hands thoroughly with soap and water immediately after use of the product.
Croatian: Odmah nakon primjene proizvoda temeljito oprati ruke vodom i sapunom.
English: Oral uptake of the product at the maximum recommended dose was well tolerated in cats, apart from some self-limiting salivation and coughing or vomiting immediately after administration.
Croatian: Peroralnu upotrebu maksimalne doze mačke dobro podnose, osim povećanog slinjenja i kašlja ili povraćanja odmah nakon uzimanja.
English: The pipettes should be kept in the outer packaging to prevent solvent loss or moisture uptake.
Croatian: Pipete čuvati u vanjskom pakovanju da bi se izbjegao gubitak otopine ili upijanje vlage.
English: Unit dose pipette made of laminated aluminium/polypropylene foil closed with an HDPE cap and packed in a laminated aluminium foil sachet.
Croatian: Jedinica doze pipeta, izrađena od laminirane aluminij / polipropilen folije zatvoreno s HDPE poklopcem i pakirno u laminirane aluminijske folijske vrećice.
English: This product is harmful after ingestion.
Croatian: Ovaj proizvod je opasan u slučaju gutanja.