FrancophonIA/ELRC3.0 huggingface dataset:
English: • if you have ever had liver disease, including hepatitis B or C (if you have hepatitis B infection, do not stop Trizivir without your doctor's advice, as your hepatitis may come back)
Slovenian: • če imate zmerno ali hudo bolezen jeter, • če ste kdaj imeli bolezen jeter, vključno s hepatitisom B ali C (če imate okužbo s hepatitisom B,
English: Each film-coated tablet contains: abacavir 300 mg (as sulfate) lamivudine 150 mg zidovudine 300 mg
Slovenian: Vsaka filmsko obložena tableta vsebuje: abakavir 300 mg (kot sulfat) lamivudin 150 mg zidovudin 300 mg
English: (Co-trimoxazole)/Lamivudine (160mg/800mg once daily for 5 days/300mg single dose)
Slovenian: trimetoprim/sulfametoksazol (kotrimoksazol)/lamivudin (160 mg/800 mg enkrat na dan 5 dni/enkraten odmerek 300 mg)
English: Immune system disorders Common: hypersensitivity Metabolism and nutrition disorders Common: anorexia Very Rare : lactic acidosis
Slovenian: Presnovne in prehranske motnje Pogosti: anoreksija Zelo redki: laktacidoza
English: One randomised, double blind, placebo controlled clinical study has compared the combination of abacavir, lamivudine and zidovudine to the combination of indinavir, lamivudine and zidovudine in treatment naive patients.
Slovenian: V randomizirani, dvojno slepi in s placebom nadzorovani študiji so pri odraslih bolnikih, ki še niso bili zdravljeni, primerjali kombinacijo abakavir, lamivudin in zidovudin s kombinacijo indinavir, lamivudin in zidovudin.
English: Zidovudine AUC ↑74% (UGT inhibition)
Slovenian: zidovudin AUC ↑74% (zavrtje UGT)
English: Respiratory, thoracic and mediastinal disorders Common: cough, nasal symptoms
Slovenian: Bolezni dihal, prsnega koša in mediastinalnega prostora Pogosti: kašelj, nazalni simptomi
English: • pentamidine or atovaquone, to treat parasitic infections such as Pneumocystis jirovecii pneumonia (often referred to as PCP)
Slovenian: • pentamidin ali atovakon za zdravljenje okužb z zajedalci, kot je pljučnica povzročena s
English: Care must be taken to eliminate the possibility of a hypersensitivity reaction if any of these symptoms occur.
Slovenian: Če se pojavi kateri koli od teh simptomov, je potrebno izključiti možnost preobčutljivostne reakcije.
English: Mild myocardial degeneration in the heart of mice and rats was observed following administration of abacavir for two years.
Slovenian: Pri miših in podganah so po dvoletnem dajanju abakavirja opazili blago degeneracijo miokarda.
English: There is no experience of overdose with Trizivir.
Slovenian: 4.9 Preveliko odmerjanje Izkušenj s prevelikim odmerjanjem zdravila Trizivir ni.
English: An uncommon side effect that may show up in blood tests is:
Slovenian: Občasen neželen učinek, ki ga lahko pokažejo preiskave krvi, je:
English: Trizivir does not cure HIV infection; it reduces the amount of virus in your body, and keeps it at a low level.
Slovenian: temveč zmanjša število virusov v telesu in njihovo število ohranja majhno.
English: • amphotericin or co-trimoxazole, to treat fungal and bacterial infections
Slovenian: • amfotericin ali kotrimoksazol za zdravljenje glivičnih in bakterijskih okužb,
English: Abacavir, lamivudine and zidovudine are not significantly metabolised by cytochrome P450 enzymes (such as CYP 3A4, CYP 2C9 or CYP 2D6) nor do they inhibit or induce this enzyme system.
Slovenian: CYP 2C9 ali CYP 2D6) znatneje ne presnavljajo, omenjenega encimskega sistema tudi ne zavirajo ali inducirajo.
English: • high doses of co-trimoxazole, an antibiotic
Slovenian: • velikih odmerkov antibiotika kotrimoksazola,
English: Before initiating abacavir therapy, clinicians should screen for HLA-B*5701.
Slovenian: Pred začetkom uvedbe zdravljenja z abakavirjem, morajo zdravniki izvesti presejanje za HLAB*5701.
English: Therefore, as dose adjustments of these may be necessary, it is recommended that separate preparations of abacavir, lamivudine and zidovudine be administered to patients with reduced renal function (creatinine clearance ≤ 50 ml/min).
Slovenian: Ker bo tako verjetno potrebno odmerek teh dveh učinkovin prilagoditi, je pri bolnikih z zmanjšanim delovanjem ledvic (kreatininski očistek ≤ 50 ml/min) priporočljivo uporabljati abakavir, lamivudin in zidovudin kot samostojna zdravila.
English: Phenotypic resistance to abacavir requires M184V with at least one other abacavir-selected mutation, or M184V with multiple TAMs.
Slovenian: Fenotipska odpornost in navzkrižna odpornost: Za fenotipsko odpornost proti abakavirju je potrebna mutacija M184V in še vsaj ena z abakavirjem povzročena mutacija ali mutacija M184V z večkratnimi mutacijami timidinskih analogov.
English: When possible, avoid chronic coadministration of Trizivir with medicinal products containing sorbitol or other osmotic acting poly-alcohols or monosaccharide alcohols (e.g. xylitol, mannitol, lactitol, maltitol).Consider more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided.
Slovenian: Če je mogoče, se izognite kronični sočasni uporabi zdravila Trizivir z zdravili, ki vsebujejo sorbitol ali druge osmotsko delujoče polialkohole oziroma monosahardine alkohole (npr. ksilitol, manitol, laktitol, maltitol).
English: Rare: pure red cell aplasia Very rare: aplastic anaemia
Slovenian: Zelo redki: čista aplazija rdečih krvničk
English: They are blue/green and capsuleshaped and are provided in blister packs containing 60 tablets or bottles containing 60 tablets with child-resistant tops.
Slovenian: Na voljo so v pretisnih omotih, ki vsebujejo 60 tablet, ali v plastenkah z za otroke varnimi zaporkami, ki vsebujejo 60 tablet.
English: Regardless of HLA-B*5701 status, patients who are diagnosed with a hypersensitivity reaction must discontinue abacavir immediately.
Slovenian: Obvladovanje preobčutljivostnih reakcij na ABC Ne glede na status HLA-B*5701, morajo bolniki, pri katerih je ugotovljena preobčutljivostna reakcija, nemudoma prenehati z jemanjem abakavirja.
English: Common: nausea, vomiting, abdominal pain, diarrhoea Rare: rises in serum amylase, pancreatitis
Slovenian: abdominalna bolečina, driska Redki: povečane vrednosti serumske amilaze, pankreatitis
English: MARKETING AUTHORISATION NUMBER(S) EU/1/00/156/002 PCTFE/PVC-Al EU/1/00/156/004 PVC/PCTFE/PVC-Al/Paper
Slovenian: ŠTEVILKA(E) DOVOLJENJA(DOVOLJENJ) ZA PROMET EU/1/00/156/002 PCTFE/PVC-Al
English: Lamivudine has not shown any genotoxic activity in the in vivo studies at doses that gave plasma concentrations up to 40 - 50 times higher than clinical plasma levels.
Slovenian: Lamivudin pri odmerkih, ki so dali 40- do 50-krat večje plazemske koncentracije od terapevtskih, in vivo ni pokazal nobenega genotoksičnega delovanja.
English: If you have stopped taking Trizivir because of a hypersensitivity reaction, you must NEVER AGAIN take Trizivir, or any other medicine containing abacavir (Kivexa, Triumeq or Ziagen).
Slovenian: Če ste zdravilo Trizivir nehali jemati zaradi preobčutljivostne reakcije, ga ne smete vzeti NIKOLI VEČ; prav tako ne smete nikoli več vzeti kakšnega drugega zdravila, ki vsebuje abakavir (Kivexa, Triumeq ali Ziagen).
English: Abacavir is metabolised primarily by the liver.
Slovenian: Abakavir se v glavnem presnavlja v jetrih.
English: Cases of pancreatitis have occurred rarely in patients treated with abacavir, lamivudine and zidovudine.
Slovenian: Pankreatitis Pri bolnikih, ki so se zdravili z abakavirjem, lamivudinom in zidovudinom so bili primeri pankreatitisa redki.
English: Tell your doctor or pharmacist if you are taking any of these.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katerokoli zdravilo;
English: Rare: cardiomyopathy
Slovenian: Redki: kardiomiopatija
English: Nucleoside and nucleotide analogues have been demonstrated in vitro and in vivo to cause a variable degree of mitochondrial damage.
Slovenian: Moteno delovanje mitohondrijev Dokazano je, da nukleozidni in nukleotidni analogi in vitro in in vivo v različni meri okvarijo mitohondrije.
English: The observed values of the peak concentrations are 9 fold greater than the IC50 of abacavir of 0.08 µg/ml or 0.26 µM when abacavir is given at 600 mg twice daily.
Slovenian: Če se je abakavir dajal v odmerku 600 mg dvakrat dnevno, so bile opažene največje koncentracije katerih vrednosti so bile 9-krat večje od IC50 abakavirja (0,08 µg/ml ali 0,26 µM).
English: Trizivir may cause other conditions to develop during HIV treatment.
Slovenian: Drugi možni neželeni učinki zdravila Trizivir Zdravilo Trizivir, lahko med zdravljenjem HIV povzroči nastanek drugih motenj.
English: Trimethoprim/sulfamethoxazole (Co-trimoxazole)/Abacavir
Slovenian: trimetoprim/sulfametoksazol (kotrimoksazol)/abakavir
English: Clarithromycin/Abacavir
Slovenian: klaritromicin/abakavir
English: The 5'-glucuronide of zidovudine is the major metabolite in both plasma and urine, accounting for approximately 50 - 80 % of the administered dose eliminated by renal excretion.
Slovenian: Zidovudin 5'-glukuronid je glavni presnovek zidovudina v plazmi in v urinu, nanj odpade približno
English: The risk for abacavir HSR to occur is high for patients who test positive for the HLA-B*5701 allele.
Slovenian: Tveganje za pojav HSR na abakavir je visoko pri bolnikih, ki so imeli pozitiven test za alel HLA
English: The adverse reactions reported with abacavir, lamivudine and zidovudine are presented in Table 2.
Slovenian: Neželeni učinki v tabeli o katerih so poročali po jemanju posameznih učinkovin Neželeni učinki, o katerih so poročali po uporabi abakavirja, lamivudina in zidovudina so predstavljene v tabeli 1.
English: The clinical status of the patient and the adverse event profile of Trizivir should be borne in mind when considering the patient's ability to drive or operate machinery.
Slovenian: Pri presojanju bolnikovih sposobnosti za vožnjo in upravljanje s stroji je potrebno upoštevati tako klinično stanje bolnika kot možne neželene učinke zdravila Trizivir.
English: Rare side effects that may show up in blood tests are:
Slovenian: Pogosti neželeni učinki, ki jih lahko pokažejo preiskave krvi, so:
English: • hypersensitivity reaction
Slovenian: • preobčutljivostna reakcija,
English: These may affect up to 1 in 1000 people:
Slovenian: Ti se lahko pojavijo pri največ 1 od 1000 bolnikov:
English: Many of the adverse reactions listed in the table occur commonly (nausea, vomiting, diarrhoea, fever, lethargy, rash) in patients with abacavir hypersensitivity.
Slovenian: Številni v tabeli navedeni neželeni učinki se pri bolnikih s preobčutljivostjo na abakavir pojavijo pogosto (navzea, bruhanje, diareja, povišana telesna temperatura, letargija, izpuščaj).
English: HLA-B*5701 screening for risk of ABC hypersensitivity should never be substituted for appropriate clinical vigilance and patient management in individuals receiving ABC.
Slovenian: Presejanje HLA-B*5701 glede tveganja za preobčutljivost na ABC ne sme pri osebah, ki prejemajo
English: As dose adjustments of lamivudine and zidovudine may be necessary it is recommended that separate preparations of abacavir, lamivudine and zidovudine be administered to patients with reduced renal function (creatinine clearance ≤ 50 ml/min).
Slovenian: Ker bo verjetno potrebno odmerek lamivudina in zidovudina prilagoditi, je pri bolnikih z zmanjšanim delovanjem ledvic (kreatininski očistek ≤ 50 ml/min) priporočljivo uporabljati abakavir, lamivudin in zidovudin kot samostojna zdravila.Trizivir je kontraindiciran pri bolnikih s terminalnim stadijem ledvične bolezni (glejte poglavje 4.3).
English: Lactic acidosis
Slovenian: Hematologija limfopenija
English: Common: headache, insomnia Very rare: peripheral neuropathy (paraesthesiae)
Slovenian: Zelo redki: periferna nevropatija (parestezije)
English: Drug Interactions:
Slovenian: Interakcije med zdravili
English: There have been reports of mitochondrial dysfunction in HIVnegative infants exposed in utero and/or post-natally to nucleoside analogues (see section 4.4).
Slovenian: Opisani so primeri motenega delovanja mitohondrijev pri dojenčkih, ki so bili in utero in/ali po rojstvu izpostavljeni nukleozidnim analogom.
English: A bioequivalence study compared Trizivir with abacavir 300 mg, lamivudine 150 mg and zidovudine 300 mg taken together.
Slovenian: Zdravilo Trizivir so v raziskavi bioekvivalentnosti primerjali s 300 mg odmerkom abakavirja, 150 mg odmerkom lamivudina in 300 mg odmerkom zidovudina, ki so bili vzeti skupaj.
English: Therefore, maintaining lamivudine therapy despite emergence of M184V mutation should only be considered in cases where no other active NRTIs are available.
Slovenian: M184V pride v poštev samo v primerih, ko drugih učinkovitih NRTI ni na voljo.
English: These may affect up to 1 in 10,000 people:
Slovenian: Ti se lahko pojavijo pri največ 1 od 10000 bolnikov:
English: Adverse reactions have been reported with abacavir, lamivudine and zidovudine used separately or in combination for therapy of HIV disease.
Slovenian: O neželenih učinkih so poročali tako med zdravljenjem bolezni HIV z abakavirjem, lamivudinom in zidovudinom posamezno kot tudi med zdravljenjem s kombinacijo vseh treh.
English: Zidovudine has not been shown to affect the number of sperm, sperm morphology and motility in man.
Slovenian: Ni bilo dokazano, da bi zidovudin vplival na število, morfologijo ali gibljivost semenčic pri moškem.
English: Very Rare : lactic acidosis
Slovenian: Zelo redki: laktacidoza
English: Ethanol/Zidovudine
Slovenian: etanol/zidovudin
English: After a median follow-up of 144 weeks, 25 % of subjects on the ZDV/3TC/ABC/EFV arm and 26 % on the ZDV/3TC/EFV arm were categorised as having virological failure.
Slovenian: Po povprečno 144 tednih spremljanja je bil virološki neuspeh opažen pri 25 % oseb, ki so prejemale ZDV/3TC/ABC/EFV, in
English: The M184V or M184I variants arise in HIV-1 infected patients treated with lamivudine-containing antiretroviral therapy and confers high-level resistance to lamivudine.
Slovenian: Odpornost in vivo (bolniki, ki so že bili zdravljeni) Pri z virusom HIV-1 okuženih bolnikih, ki so se zdravili s protiretrovirusnim zdravljenjem, ki je vsebovalo lamivudin, sta se pojavili varianti M184V ali M184I, ki sta povzročili visoko stopnjo odpornosti proti lamivudinu.
English: ACTG5095 was a randomised (1:1:1), double-blind, placebo-controlled trial performed in 1147 antiretroviral naïve HIV-1 infected adults, comparing 3 regimens: zidovudine (ZDV), lamivudine (3TC), abacavir (ABC), efavirenz (EFV) vs ZDV/3TC/EFV vs ZDV/3TC/ABC.
Slovenian: ACTG5095 je bilo randomizirano (1:1:1), dvojno slepo, s placebom nadzorovano preskušanje, ki so ga izvedli pri 1147 bolnikih, okuženih z virusom HIV-1, ki se še niso zdravili s protiretrovirusnimi zdravili.
English: General disorders and administration site conditions Common: fever, lethargy, fatigue
Slovenian: Splošne težave in spremembe na mestu aplikacije Pogosti: povišana telesna temperatura, letargija, utrujenost
English: Trizivir 300 mg/150 mg/300 mg film-coated tablets abacavir/lamivudine/zidovudine
Slovenian: Trizivir 300 mg/150 mg/300 mg tablete abakavir/lamivudin/zidovudin
English: Lactic acidosis, usually associated with hepatomegaly and hepatic steatosis, has been reported with the use of zidovudine .
Slovenian: Pri uporabi zidovudina so poročali o laktacidozi, navadno povezani s hepatomegalijo in z jetrno steatozo.
English: CONTACT YOUR DOCTOR IMMEDIATELY for advice on whether you should stop taking Trizivir if:
Slovenian: ZDRAVNIKOM, če morate prenehati z jemanjem zdravila Trizivir v primeru da:
English: If the doctor thinks they may have been related, you will be told never again to take Trizivir, or any other medicine containing abacavir (Kivexa,Triumeq or Ziagen).
Slovenian: Če bo ocenil, da so morda bili povezani, vam bo naročil, da nikoli več ne smete vzeti zdravila Trizivir ali kakšnega drugega zdravila, ki vsebuje abakavir (Kivexa, Triumeq ali Ziagen).
English: Dose adjustments in patients with haematological adverse reactions Dose adjustment of zidovudine may be necessary if the haemoglobin level falls below 9 g/dl or 5.59 mmol/l or the neutrophil count falls below 1.0 x 109/l (see sections 4.3 and 4.4).
Slovenian: Če se vrednost hemoglobina zmanjša pod 9 g/dl ali 5,59 mmol/l, ali se število nevtrofilcev zmanjša pod 1,0 x 109/l (glejte poglavji 4.3 in 4.4), bo verjetno potrebno odmerek zidovudina prilagoditi.
English: Zidovudine is primarily metabolised by UGT enzymes; co-administration of inducers or inhibitors of UGT enzymes could alter zidovudine exposure.
Slovenian: UGT; sočasna uporaba induktorjev ali zaviralcev encimov UGT lahko spremeni izpostavljenost zidovudinu.
English: Rifampicin/Zidovudine (600mg once daily/200 mg thrice daily)
Slovenian: rifampicin/zidovudin (600mg enkrat na dan /200 mg trikrat na dan )
English: • stiffness in the joints
Slovenian: • togost v sklepih,
English: • indigestion, taste disturbance
Slovenian: • težave z želodcem, motnje okušanja,
English: Didanosine/Zidovudine
Slovenian: didanozin/zidovudin
English: • if you have a very low red blood cell count (anaemia) or a very low white blood cell count (neutropenia) Check with your doctor if you think any of these apply to you.
Slovenian: • če imate zelo malo rdečih krvnih celic (anemijo) ali zelo malo belih krvnih celic (nevtropenijo).
English: Lactic acidosis is a rare but serious side effect Some people taking Trizivir develop a condition called lactic acidosis, together with an enlarged liver.
Slovenian: Nekaterim bolnikom, ki jemljejo zdravilo Trizivir, se pojavi stanje, imenovano laktacidoza, skupaj s povečanjem jeter.
English: ANTI-INFECTIVE PRODUCTS Atovaquone/Abacavir
Slovenian: PROTIMIKROBNA ZDRAVILA atovakon/abakavir
English: Stavudine/Abacavir
Slovenian: stavudin/abakavir
English: Drugs by Therapeutic Area Interaction Geometric mean change
Slovenian: Zdravila po terapevtskem področju Medsebojno delovanje
English: As dose adjustment of Trizivir is not possible separate preparations of zidovudine, abacavir and lamivudine should be used.
Slovenian: Ker z zdravilom Trizivir prilagajanje odmerka posamezne učinkovine ni možno, je potrebno uporabiti zidovudin, abakavir in lamivudin kot samostojna zdravila.
English: Trimethoprim: AUC ↔ Sulfamethoxazole: AUC ↔
Slovenian: lamivudin: AUC 40% trimetoprim: AUC ↔ sulfametoksazol: AUC ↔ (zavrtje organskega kationskega prenašalca)
English: Uncommon: thrombocytopenia and pancytopenia with marrow hypoplasia
Slovenian: Občasni: trombocitopenija in pancitopenija s hipoplazijo kostnega mozga
English: The active substances in each Trizivir film-coated tablet are 300 mg of abacavir (as sulfate), 150 mg lamivudine and 300 mg zidovudine.
Slovenian: Zdravilne učinkovine v vsaki Trizivir filmsko obloženi tebleti so 300 mg abakavirja (v obliki sulfata),150 mg lamivudina in 300 mg zidovudina.
English: As dose adjustment of Trizivir is not possible, separate preparations of abacavir, lamivudine and zidovudine should be used.
Slovenian: Ker z zdravilom Trizivir prilagajanje odmerka posamezne učinkovine ni možno, je potrebno uporabiti abakavir, lamivudin in zidovudin kot samostojna zdravila.
English: Old infections may flare up
Slovenian: Simptomi okužbe in vnetja Možnost ponovnega zagona starih okužb
English: Trizivir contains abacavir, lamivudine and zidovudine, therefore any interactions identified for these individually are relevant to Trizivir.
Slovenian: 4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Zdravilo Trizivir vsebuje abakavir, lamivudin in zidovudin, zato je katerakoli interakcija, povezana s posamezno zdravilno učinkovino, relevantna tudi za zdravilo Trizivir.
English: Moderate amount of data (more than 600 outcomes from first trimester)
Slovenian: Obstaja zmerna količina podatkov (več kot 600 izidov po izpostavljenosti v prvem trimesečju), ki niso pokazali malformacijske toksičnosti za abakavir.
English: GENERAL CLASSIFICATION FOR SUPPLY Medicinal product subject to medical prescription.
Slovenian: Izdaja zdravila je le na recept.
English: Number of subjects with ≥1 TAM. TAMs might be selected when thymidine analogs are associated with abacavir.
Slovenian: Število oseb z ≥ 1 mutacijo timidinskih analogov.
English: Abacavir, lamivudine and zidovudine are rapidly and well absorbed from the gastro-intestinal tract following oral administration.
Slovenian: Po peroralnem dajanju se abakavir, lamivudin in zidovudin iz prebavil hitro in dobro absorbirajo.
English: Trizivir was shown to be bioequivalent to abacavir 300 mg, lamivudine 150 mg and zidovudine 300 mg given as separate tablets for AUC0-∞ and Cmax.
Slovenian: AUC0-∞ in Cmax bioekvivalenten 300 mg odmerku abakavirja, 150 mg odmerku lamivudina in 300 mg odmerku zidovudina, ki so dani v obliki ločenih tablet.
English: • phenytoin, for treating epilepsy Tell your doctor if you are taking phenytoin.
Slovenian: Zdravniku morate povedati, če jemljete fenitoin.
English: • wind (flatulence)
Slovenian: • vetrovi, • srbenje,
English: • loss of appetite
Slovenian: • izguba teka,
English: No definitive recommendation on dose reduction is possible in patients with mild hepatic impairment due to substantial variability of abacavir exposure in this patient population.
Slovenian: Ker je pri bolnikih z blago jetrno okvaro izpostavljenost abakavirju precej variabilna, pri tej populaciji bolnikov ne moremo podati dokončnih priporočil glede zmanjšanja odmerka.
English: Treatment with Trizivir should be stopped immediately if clinical signs, symptoms or laboratory abnormalities suggestive of pancreatitis occur.
Slovenian: Če klinični znaki, simptomi ali laboratorijska odstopanja kažejo na možnost pankreatitisa, je potrebno zdravljenje z zdravilom Trizivir nemudoma prekiniti.
English: Abacavir-resistant isolates of HIV-1 have been selected in vitro and are associated with specific genotypic changes in the RT codon region (codons M184V, K65R, L74V and Y115F).
Slovenian: In vitro so bili izolirani izolati virusa HIV-1 odporni na abakavir, ki so bili povezani s specifičnimi genotipskimi spremembami kodonskega področja (kodoni M184V, K65R, L74V in Y115F) RT. In vitro se virusna odpornost na abakavir razvije relativno počasi, pri čemer so potrebne večkratne mutacije za klinično pomembno povečanje EC50 v primerjavi z divjim tipom virusa.
English: Single doses up to 1,200 mg and daily doses up to 1,800 mg of abacavir have been administered to patients in clinical studies.
Slovenian: V kliničnih študijah so bolniki prejemali abakavir bodisi v enkratnih odmerkih do 1200 mg bodisi v dnevnih odmerkih do 1800 mg,
English: The special warnings and precautions relevant to abacavir, lamivudine and zidovudine are included in this section.
Slovenian: V to poglavje so vključena posebna opozorila in previdnostni ukrepi, ki se nanašajo na abakavir,
English: If you get any symptoms of infection while you're taking Trizivir: Tell your doctor immediately.
Slovenian: Če mislite, da imate preobčutljivostno reakcijo na zdravilo Trizivir, se morate nemudoma posvetovati s svojim zdravnikom.
English: The pharmacokinetics of abacavir have been studied in patients with mild hepatic impairment (Child-Pugh score 5-6) receiving a single 600 mg dose; the median (range) AUC value was 24.1 (10.4 to 54.8) ug.h/ml.
Slovenian: Farmakokinetične lastnosti abakavirja so preučevali pri bolnikih z blago jetrno okvaro (Child-Pugh ocena 5-6), ki so dobili abakavir v enkratnem odmerku 600 mg.
English: Gastrointestinal disorders Common: nausea, vomiting, diarrhoea
Slovenian: Bolezni prebavil Pogosti: navzea, bruhanje, driska
English: Zidovudine showed clastogenic effects in oral repeated dose micronucleus tests in mice and rats.
Slovenian: Zidovudin, v ponavljajočih odmerkih peroralno apliciran mišim in podganam v okviru mikronukleusnega testa, je imel klastogene učinke.
English: Valproic acid/Abacavir
Slovenian: valprojska kislina/abakavir
English: Very common: Nausea Common: vomiting, abdominal pain, and diarrhoea Uncommon: flatulence Rare: oral mucosa pigmentation, taste disturbance dyspepsia, pancreatitis
Slovenian: Občasni: flatulenca Redki: pigmentacija ustne sluznice, motnje okusa, dispepsija, pankreatitis
English: - shortness of breath, sore throat or cough
Slovenian: - povišana telesna temperatura - zasoplost, vneto žrelo ali kašelj