FrancophonIA/ELRC3.0 huggingface dataset:
English: Vandetanib is an inhibitor of the organic cation 2 (OCT2) transporter.
Croatian: Vandetanib je inhibitor prijenosnika organskih kationa 2 (OCT2).
English: Whilst the study size is small owing to the rarity of MTC in children, it is considered representative of the target population.
Croatian: Iako je veličina uzorka u ispitivanju malena zbog rijetke pojave medularnog karcinoma štitnjače u djece, smatra se reprezentativnim za ciljanu populaciju.
English: • carbamazepine and phenobarbital (used to control seizures)
Croatian: • karbamazepin i fenobarbital (koriste se za kontrolu epileptičkih napada)
English: A randomised, double-blind, placebo-controlled study (Study 58) was conducted to demonstrate safety and efficacy of vandetanib 300 mg versus placebo.
Croatian: Randomizirano, dvostruko slijepo, placebom kontrolirano ispitivanje (Ispitivanje 58) provedeno je s ciljem da se pokažu sigurnost primjene i djelotvornost vandetaniba u dozi od 300 mg u odnosu na placebo.
English: • Regularly during Caprelsa treatment
Croatian: • redovito tijekom liječenja lijekom Caprelsa
English: months n-vandetanib 231 196 169 140 40 1 0 n-placebo 100 71 57 45 13 0 0 ____ vandetanib 300 mg, ------ placebo, y-axis=PFS, x-axis=time in months, n-vandetanib=number of patients at risk-vandetanib, n-placebo=number of patients at risk-placebo HR = 0.46, 95%CI (0.31-0.69), p = 0.0001
Croatian: Slika 1. Kaplan Meierov prikaz PFS-a mjeseci n-vandetanib 231 196 169 140 40 1 0 n-placebo 100 71 57 45 13 0 0 ____ vandetanib 300 mg, ------ placebo, os y = PFS, os x = vrijeme u mjesecima, n-vandetanib = broj bolesnika pod rizikom-vandetanib, n-placebo = broj bolesnika pod rizikom-placebo HR = 0,46; 95% CI (0,31 - 0,69), p = 0,0001 PFS
English: - if you have a heart problem that you were born with called ‘congenital long QTc syndrome'.
Croatian: ako od rođenja imate srčanu tegobu pod nazivom „urođeni sindrom dugog QT intervala“.
English: • Blurred vision, including mild changes in the eye which can lead to blurred vision (corneal opacity).
Croatian: • zamagljen vid, uključujući blage promjene u oku koje mogu dovesti do zamagljenja vida
English: CTN Response
Croatian: Odgovor CTN-a
English: Reduction in dose may be necessary (see section 4.8).
Croatian: Možda će biti potrebno sniziti dozu lijeka (vidjeti dio 4.8).
English: The secondary endpoints were evaluation of overall objective response rate (ORR), disease control rate (DCR) defined as, partial response (PR) or complete response (CR) or stable disease (SD) lasting at least 24 weeks, duration of response (DOR), time to worsening of pain based on Brief Pain Inventory (BPI) worst pain scale, and overall survival (OS).
Croatian: Sekundarni ishodi bili su procijeniti: ukupan udio objektivnog odgovora (engl. objective response rate, ORR), udio kontrolirane bolesti (engl. disease control rate, DCR) definirane kao djelomičan odgovor (engl. partial response, PR), potpun odgovor (engl. complete response, CR) ili stabilna bolest (engl. stable disease, SD) u trajanju od najmanje 24 tjedna, trajanje odgovora (engl. duration of response, DOR), vrijeme do pogoršanja boli mjereno ljestvicom najjače boli u Kratkom upitniku o boli (engl.
English: An increase in the frequency and severity of some adverse reactions, like rash, diarrhoea and hypertension was observed at multiple doses at and above 300 mg in healthy volunteer studies and in patients.
Croatian: Opažena je povećana učestalost i težina nekih nuspojava poput osipa, proljeva i hipertenzije kod primjene višestrukih doza od 300 mg i viših u ispitivanjima na zdravim dobrovoljcima i u bolesnika.
English: Dosing for paediatric patients should be on the basis of BSA in mg/m2.
Croatian: Doziranje za pedijatrijske bolesnike treba se temeljiti na površini tijela (Body surface area, BSA) u mg/m2.
English: Fourteen of the 28 patients (50%) who stopped vandetanib for an adverse event discontinued without a dose reduction.
Croatian: Četrnaest od 28 bolesnika (50%) koji su prestali uzimati vandetanib zbog štetnog događaja prekinulo je liječenje bez smanjenja doze.
English: • The need to counsel patients about the risk of prolonged QTc and PRES and inform them of what symptoms and signs to be aware of and the actions to take;
Croatian: • Napomenu da je bolesnicima potrebno objasniti rizik od produljenja QTc-intervala i PRES-a te ih uputiti kojih simptoma i znakova moraju biti svjesni i što treba poduzeti ako se pojave.
English: • Dehydration.
Croatian: • dehidracija.
English: This suggests that vandetanib slows but does not prevent wound healing.
Croatian: Ovo ukazuje na to da vandetanib usporava, ali ne sprečava zacjeljivanje rana.
English: No studies to establish the effects of vandetanib on ability to drive and use machines have been conducted.
Croatian: Nisu provedena ispitivanja kako bi se utvrdili učinci vandetaniba na sposobnost upravljanja vozilima i rada sa strojevima.
English: The patient will be provided with the Patient Alert Card with each prescription.
Croatian: Bolesnik će dobiti Karticu s upozorenjima za bolesnika uz svaki liječnički recept.
English: These findings occurred at clinically-relevant plasma concentrations, were largely reversible within 4 weeks of cessation of dosing and were attributable to inhibition of vascular endothelial growth factor receptor (VEGFR) or EGFR.
Croatian: Ovi su nalazi nastupili pri koncentracijama u plazmi značajnima za kliničku primjenu, a bili su uglavnom reverzibilni unutar četiri tjedna od prestanka doziranja te ih se pripisuje inhibiciji receptora vaskularnog endotelnog faktora rasta ili EGFR-a.
English: • Inflammation of a follicle, especially a hair follicle.
Croatian: • upala folikula, osobito korijena dlake.
English: The liquid can also be administered through nasogastric or gastrostomy tubes.
Croatian: Tekućina se može primijeniti i kroz nazogastričnu sondu ili gastrostomu.
English: Results of a pharmacodynamic and pharmacokinetic interaction study indicated that co-administration with ondansetron in healthy patients appeared to have little effect on the pharmacokinetics of vandetanib, but had a small additive effect on the prolongation of the QTc interval of approximately 10 ms.
Croatian: Rezultati ispitivanja farmakokinetičkih i farmakodinamičkih interakcija pokazali su da je istodobna primjena s ondanzetronom u zdravih ispitanika tek slabo utjecala na farmakokinetiku vandetaniba, ali je imala malen aditivan učinak na produljenje QTc-intervala od približno 10 ms.
English: A 2-year carcinogenicity study in rats was impaired by low survival in the high dose female group and limited exposure of the animals to vandetanib; however, no carcinogenic effects were observed in the remaining animals.
Croatian: Značajnost dvogodišnjeg ispitivanja kancerogenosti kod štakora bila je umanjena zbog niskog preživljenja skupine ženki kojoj je primijenjena visoka doza i ograničene izloženosti vandetanibu u životinja; međutim, u ostalih životinja nisu opaženi kancerogeni učinci.
English: Keep in mind Caprelsa may make you feel tired, weak, or cause blurred vision.
Croatian: Imajte na umu da Caprelsa može izazvati umor, slabost i zamagljen vid.
English: These may be common (affecting less than 1 in 10 people) or uncommon (affects less than 1 in 100 people) depending on the type of skin reaction.
Croatian: Ove nuspojave mogu biti česte (javljaju se u manje od 1 na 10 osoba) ili manje česte (javljaju se u manje od 1 na 100 osoba), ovisno o vrsti kožne reakcije.
English: • What are the side effects associated with CAPRELSA and which monitoring is requested;
Croatian: • koje su nuspojave povezane s lijekom CAPRELSA i koje se praćenje zahtijeva;
English: Only one supply per prescription is allowed.
Croatian: Dozvoljeno je samo jedno izdavanje lijeka po liječničkom receptu.
English: Caprelsa has uncommonly been associated with life-threatening changes in heart rhythm.
Croatian: Caprelsa je manje često bila povezana s promjenama srčanog ritma koje su opasne po život.
English: Your doctor will discuss with you the benefits and risks of taking Caprelsa during this time.
Croatian: Liječnik će s Vama porazgovarati o koristima i rizicima uzimanja lijeka Caprelsa u trudnoći.
English: • The role and use of the Patient Alert Card.
Croatian: • Ulogu i korištenje Kartice s upozorenjima za bolesnika
English: Survival status and the median final overall survival (81.6 months in the vandetanib arm and 80.4 months in the placebo arm) were similar across both treatment arms.
Croatian: Status preživljenja i medijan konačnog ukupnog preživljenja (81,6 mjeseci u skupini koja je primala vandetanib i 80,4 mjeseci u skupini koja je primala placebo) bili su slični u obje liječene skupine.
English: AstraZeneca UK Limited, Macclesfield, Cheshire, SK10 2NA, United Kingdom Or
Croatian: AstraZeneca UK Limited, Macclesfield, Cheshire, SK10 2NA, Ujedinjeno Kraljevstvo ili
English: In consideration of the high intra-individual variability of the response to anticoagulation, and the possibility of interaction between vitamin K antagonists and chemotherapy, an increased frequency of the INR (International Normalised Ratio) monitoring is recommended, if it is decided to treat the patient with vitamin K antagonists.
Croatian: S obzirom na velike intraindividualne razlike u odgovoru na antikoagulanse i moguće interakcije između antagonista vitamina K i kemoterapije, ako se bolesnika odluči liječiti antagonistima vitamina K, preporučuje se češća kontrola INR-a (međunarodni normalizirani omjer).
English: * 13.4% vandetanib patients had QTc (Bazett's) ≥ 500 ms compared with 1.0% placebo patients.
Croatian: * 13,4% bolesnika koji su primali vandetanib imalo je QTc (Bazettova formula) ≥ 500 ms, u usporedbi s 1,0% bolesnika koji su primali placebo.
English: CTN less than 500 pg/ml
Croatian: Vrijednosti kalcitonina (CTN) niže od 500 pg/ml
English: There is limited data with 300 mg in patients with moderate renal impairment: the dose needed to be lowered to 200 mg in 5 out of 6 patients.
Croatian: Podaci o primjeni doze od 300 mg u bolesnika s umjerenim oštećenjem bubrega su ograničeni: dozu je trebalo smanjiti na 200 mg u 5 od 6 bolesnika.
English: The Patient Alert Card should include the following key elements:
Croatian: Kartica s upozorenjima za bolesnika mora uključivati sljedeće ključne elemente:
English: Caprelsa comes in blister packs of 30 tablets.
Croatian: Caprelsa je dostupna u blister pakiranjima s 30 tableta.
English: Medication errors in the paediatric population
Croatian: Medikacijske pogreške u pedijatrijskoj populaciji
English: Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Ireland
Croatian: Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Irska
English: The analysis was performed using a log rank test with treatment as the only factor.
Croatian: Analiza je provedena korištenjem log-rang testa u kojemu je liječenje bilo jedini faktor.
English: In healthy male subjects, the exposure to vandetanib was reduced by 40% when given together with the potent CYP3A4 inducer, rifampicin.
Croatian: Kod zdravih muških ispitanika, izloženost vandetanibu je bila smanjena za 40% kada se davao zajedno sa potentnim CYP3A4 induktorom, rifampicinom.
English: The risk of Torsades may be increased in patients with electrolyte imbalance (see section 4.8).
Croatian: Rizik od nastupa torsades de pointes može biti povećan u bolesnika s neravnotežom elektrolita (vidjeti dio 4.8).
English: • ondansetron (used to treat nausea and vomiting)
Croatian: • ondanzetron (koristi se za liječenje mučnine i povraćanja)
English: Eight percent of patients had a dose reduction due to QTc prolongation.
Croatian: U 8% bolesnika je zbog produljenja QTc-intervala smanjena doza lijeka.
English: • Loss of hair from the head or body (alopecia).
Croatian: • gubitak kose ili dlaka (alopecija).
English: crospovidone (type A), povidone (K29-32), magnesium stearate, hypromellose, macrogol and titanium dioxide (E171).
Croatian: (tip A), povidon (K29-32), magnezijev stearat, hipromeloza, makrogol i titanijev dioksid (E171).
English: • CAPRELSA prolongs the QTc interval and can cause Torsades de pointes and sudden death
Croatian: • CAPRELSA produljuje QTc-interval i može uzrokovati torsades de pointes i iznenadnu smrt.
English: • Details of medicinal products where the co-administration of CAPRELSA is either contraindicated or not recommended;
Croatian: • Detalje o lijekovima čija je istodobna primjena s lijekom CAPRELSA kontraindicirana ili se ne preporučuje.
English: At 12 months, the proportion of patients alive and progression-free was 192 (83%) for patients randomised to vandetanib and 63 (63%) for patients randomised to placebo.
Croatian: Nakon 12 mjeseci je udio bolesnika koji su bili živi i bez progresije bolesti bio 192 (83%) među bolesnicima randomiziranim na vandetanib i 63 (63%) među bolesnicima randomiziranim na placebo.
English: Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk, CB9 8PU, United Kingdom Or
Croatian: Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk, CB9 8PU, Ujedinjeno Kraljevstvo ili
English: M918T mutation is the most frequent mutation observed in patients with sporadic MTC; however it cannot be ruled out that some patients tested RET negative for M918T mutation might be positive for mutation on other exons.
Croatian: Mutacija M918T je najčešće opažena mutacija u bolesnika sa sporadičnim medularnim karcinomom štitnjače; međutim, ne može se isključiti da bi neki bolesnici s negativnim rezultatom mutacije M918T mogli biti pozitivni na mutaciju na drugim eksonima.
English: If you forget to take Caprelsa
Croatian: Ako zaboravite uzeti lijek Caprelsa
English: All prescribers of Caprelsa must be familiar with the Physician Information and Management Guidelines.
Croatian: Svi liječnici koji propisuju lijek Caprelsa moraju biti upoznati s Informacijama za liječnike i Smjernicama za liječenje.
English: Caprelsa works by slowing down the growth of new blood vessels in tumours (cancers).
Croatian: Caprelsa djeluje tako da usporava rast novih krvnih žila u tumoru (raku).
English: In repeat-dose toxicity studies of up to 9 months duration, effects included emesis, body weight loss and diarrhoea in dogs and physeal dysplasia in young dogs and rats with open growth plates.
Croatian: U ispitivanjima toksičnosti ponovljenih doza u trajanju do devet mjeseci, opaženi učinci obuhvaćaju emezu, gubitak tjelesne težine i proljev kod pasa te fizalnu displaziju kod mladih pasa i štakora s otvorenim pločama rasta.
English: In ex vivo plasma samples from colorectal cancer patients at steady state exposure after 300 mg once daily, the mean percentage protein binding was 93.7% (range 92.2 to 95.7%).
Croatian: pri izloženosti u stanju dinamičke ravnoteže nakon primjene doze od 300 mg jedanput na dan, prosječno vezanje za proteine iznosilo je 93,7% (u rasponu od 92,2 do 95,7%).
English: If you get side effects, your doctor may tell you to take Caprelsa at a lower dose.
Croatian: Ako dobijete nuspojave, liječnik Vam može reći da uzimate lijek Caprelsa u manjoj dozi.
English: Vandetanib and/or its metabolites is excreted into milk in rats and found in plasma of pups following dosing to lactating rats (see section 5.3).
Croatian: Vandetanib i/ili njegovi metaboliti izlučuju se u mlijeko štakorica i nađeni su u plazmi mladunčadi nakon primjene štakoricama u laktaciji (vidjeti dio 5.3).
English: Administration of vandetanib with potent CYP3A4 inducers should be avoided.
Croatian: Primjenu vandetaniba s potentnim CYP3A4 induktorima treba izbjegavati.
English: Vandetanib has not been studied in patients with ventricular arrhythmias or recent myocardial infarction.
Croatian: Vandetanib nije ispitivan u bolesnika s ventrikularnim aritmijama ili nedavnim infarktom miokarda.
English: Cardiac impairment was defined as patients with previous cardiovascular abnormality.
Croatian: Srčani poremećaj definiran je kao stanje bolesnika koji su prethodno imali neki kardiovaskularni poremećaj.
English: • If it is less than 12 hours until your next dose: Skip the missed dose.
Croatian: • Ako je do sljedeće doze ostalo manje od 12 sati: Preskočite propuštenu dozu.
English: These may be signs of a condition called RPLS (Reversible Posterior Leukoencephalopathy Syndrome).
Croatian: To mogu biti znakovi stanja koje se zove RPLS (sindrom reverzibilne posteriorne leukoencefalopatije).
English: Additional monitoring of QTc, electrolytes and renal function are required especially in case of diarrhoea, increase in diarrhoea/dehydration, electrolyte imbalance and/or impaired renal function.
Croatian: Potrebno je dodatno nadzirati QTc-interval, elektrolite i bubrežnu funkciju, osobito u slučaju proljeva, pojačanog proljeva/dehidracije, neravnoteže elektrolita i/ili oštećenja bubrežne funkcije.
English: Effects noted in other studies included inhibition of human ether-à-go-go related gene (hERG) current and prolongation of QTc interval in dogs.
Croatian: Učinci zabilježeni u drugim ispitivanjima obuhvaćaju inhibiciju hERG kanala (engl. human ether-à-go-go related gene) i produljenje QTc-intervala u pasa.
English: Furthermore, the bradycardiac effect of digoxin may increase the risk of vandetanib QTc interval prolongation and Torsade de Pointes.
Croatian: Dodatno, bradikardijski učinak digoksina može povećati rizik od produljenja QTc intervala i Torsade de Pointes uzrokovanih vandetanibom.
English: Your doctor may tell you to take Caprelsa at a lower or increased dose (such as two 100 mg tablets or one 100 mg tablet).
Croatian: Caprelsa u manjoj ili većoj dozi (primjerice dvije tablete od 100 mg ili jednu tabletu od 100 mg).
English: If it gets severe, tell your doctor straight away.
Croatian: Ako se proljev pogorša, odmah obavijestite svog liječnika.
English: A glucuronide conjugate was seen as a minor metabolite in excreta only.
Croatian: Glukuronidni konjugat, kao manje važan metabolit, opažen je samo u izlučevinama.
English: • itraconazole, ketoconazole, ritonavir, clarithromycin, rifampicin and moxifloxacin (medicines used to treat infections)
Croatian: • itrakonazol, ketokonazol, ritonavir, klaritromicin, rifampicin i moksifloksacin (lijekovi koji se koriste za liječenje infekcija)
English: If vandetanib is used during pregnancy or if the patient becomes pregnant while receiving vandetanib, she should be apprised of the potential for foetal abnormalities or loss of the pregnancy.
Croatian: Ako se vandetanib koristi u trudnoći ili bolesnica zatrudni tijekom liječenja vandetanibom, treba je upozoriti na mogućnost malformacija ploda ili gubitka trudnoće.
English: Starting vandetanib dose was 100mg/m2/day for all patients except for one who started at 150mg/m2/day.
Croatian: 100 mg/m2/dan za sve bolesnike, osim za jednog koji je počeo s dozom od 150 mg/m2/dan.
English: Your doctor may recommend you take Caprelsa at a lower dose or stop taking Caprelsa.
Croatian: Liječnik Vam može preporučiti da uzimate lijek Caprelsa u nižoj dozi ili da prestanete uzimati lijek Caprelsa.
English: Of the patients enrolled in the study 10 patients on vandetanib and 4 on placebo (4% of all patients) had a World Health Organization performance status (WHO PS) score of ≥ 2 and 28 (12.1%) patients on vandetanib and 10 (10.1%) on placebo had cardiac impairment.
Croatian: Od bolesnika uključenih u ispitivanje, deset bolesnika liječenih vandetanibom i četiri bolesnika koja su primala placebo (4% svih bolesnika) imali su ocjenu općeg stanja prema Svjetskoj zdravstvenoj organizaciji (WHO PS) ≥ 2, a 28 (12,1%) bolesnika liječenih vandetanibom i 10 (10,1%) bolesnika koji su primali placebo imali su srčani poremećaj.
English: Calcium hydrogen phosphate dihydrate Microcrystalline cellulose Crospovidone (type A) Povidone (K 29-32) Magnesium stearate
Croatian: Jezgra tablete kalcijev hidrogenfosfat dihidrat celuloza, mikrokristalična krospovidon (tip A) povidon (K 29-32) magnezijev stearat
English: In the event of an overdose, further doses must be interrupted, and appropriate measures taken to assure that an adverse event has not occurred, i.e. ECG within 24 hours to determine QTc prolongation.
Croatian: U slučaju predoziranja, daljnja se primjena lijeka mora privremeno prekinuti te se moraju poduzeti odgovarajuće mjere kako bi se ustanovilo da nije nastupila kakva nuspojava, tj. snimiti EKG u roku od 24 sata da se utvrdi produljenje QTc-intervala.
English: Results should be interpreted with caution due to the high percentage of patients in the placebo arm switching to openlabel vandetanib (79.0% [79/100] of patients).
Croatian: Rezultati se trebaju interpretirati s oprezom zbog visokog udjela bolesnika koji su iz skupine koja je primala placebo prešli u otvoreno ispitivanje s vandetanibom (79,0% [79/100] bolesnika).
English: Serum potassium, serum magnesium and serum calcium should be kept within normal range to reduce the risk of ECG QTc prolongation.
Croatian: Razine kalija, magnezija i kalcija u serumu treba održavati u granicama normalnih vrijednosti kako bi se smanjio rizik od produljenja QTc-intervala.
English: QTc interval should be carefully assessed prior to initiation of treatment.
Croatian: Prije započinjanja liječenja treba pažljivo odrediti QTc-interval.
English: Vandetanib at a dose of 300 mg is associated with a substantial and concentration dependent prolongation in QTc (mean 28 msec, median 35 msec).
Croatian: Primjena vandetaniba u dozi od 300 mg povezana je sa značajnim i o koncentraciji ovisnim produljenjem QTc-intervala (prosječno za 28 ms, medijan 35 ms).
English: Following oral administration of vandetanib absorption is slow with peak plasma concentrations typically achieved at a median of 6 hours, range 4-10 hours, after dosing.
Croatian: Nakon peroralne primjene vandetaniba apsorpcija je spora, a vršne koncentracije u plazmi obično se postižu u medijanu od 6 sati nakon doziranja, s rasponom od 4 - 10 sati.
English: In clinical studies, a small number of patients had surgery while receiving vandetanib and there were no reported wound healing complications.
Croatian: U kliničkim ispitivanjima je mali broj bolesnika operiran za vrijeme uzimanja vandetaniba i nisu prijavljene komplikacije sa zacjeljivanjem rana.
English: Either symptomatic disease or progressive disease alone is not enough to prompt the need of treatment with vandetanib.
Croatian: ili samo progresivna bolest nisu dovoljan razlog za liječenje vandetanibom.
English: Caprelsa is indicated for the treatment of aggressive and symptomatic medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease.
Croatian: Caprelsa je indicirana za liječenje agresivnog i simptomatskog medularnog karcinoma štitnjače u bolesnika s neoperabilnom lokalno uznapredovalom ili metastatskom bolešću.
English: • Loss of heart function.
Croatian: • gubitak srčane funkcije.
English: RET mutation status was obtained at the time of diagnosis in a majority of patients and could have changed since.
Croatian: * Status mutacije protoonkogena RET u većine je bolesnika utvrđen u trenutku postavljanja dijagnoze i mogao se otada promijeniti.
English: N Response rate ORb
Croatian: N Stopa odgovora ORb
English: • Abnormal color of urine.
Croatian: • neuobičajena boja mokraće.
English: At various exposure durations, median haemoglobin levels in patients treated with vandetanib were increased by 0.5-1.5 g/dl compared to baseline.
Croatian: Pri različitom trajanju izloženosti, medijan razine hemoglobina u bolesnika liječenih vandetanibom porastao je za 0,5-1,5 g/dl u odnosu na početne vrijednosti.
English: Therefore, the concomitant use of vandetanib with medicinal products known to also prolong the QTc interval and/or induce Torsades de pointes is either contraindicated or not recommended depending on existing alternative therapies.
Croatian: Stoga je istodobna primjena vandetaniba s lijekovima za koje se zna da produljuju QTc-interval i/ili izazivaju torsades de pointes ili kontraindicirana ili se ne preporučuje, ovisno o postojećim terapijskim alternativama.
English: CEA Response
Croatian: Odgovor CEA
English: Due to the increased thrombotic risk in patients with cancer, the use of anticoagulation is frequent.
Croatian: Zbog povećanog rizika od tromboze u bolesnika koji boluju od raka, česta je primjena antikoagulacijske terapije.