FrancophonIA/ELRC3.0 huggingface dataset:
English: If it is considered that co-administration is unavoidable, then it is recommended that the dose of sirolimus should be greatly reduced at the time of initiation of posaconazole therapy and that there should be very frequent monitoring of trough concentrations of sirolimus in whole blood.
Slovenian: Če pa menite, da je uporaba posakonazola nujna, potem priporočamo, da ob uvedbi zdravljenja s posakonazolom močno zmanjšate odmerek sirolimusa in zelo pogosto merite najnižje koncentracije sirolimusa v bolnikovi polni krvi.
English: Treatment of azole-susceptible Oropharyngeal Candidiasis (OPC) A randomised, evaluator-blind, controlled study was completed in HIV-infected patients with azolesusceptible oropharyngeal candidiasis (most patients studied had C. albicans isolated at baseline).
Slovenian: Zdravljenje orofaringealne kandidiaze, občutljive na azole (OPC) Randomizirana, za ocenjevalce slepa kontrolirana študija je bila opravljena pri bolnikih, okuženih s HIV, ki so imeli na azole občutljivo orofaringealno kandidiazo (pri večini bolnikov v tej študiji so na začetku študije izolirali C. albicans).
English: Therefore, inhibitors (e.g. verapamil, ciclosporin, quinidine, clarithromycin, erythromycin, etc.) or inducers (e.g. rifampicin, rifabutin, certain anticonvulsants, etc.) of these clearance pathways may increase or decrease posaconazole plasma concentrations, respectively.
Slovenian: Zaviralci (npr. verapamil, ciklosporin, kvinidin, klaritromicin, eritromicin, itd.) ali induktorji (npr. rifampicin, rifabutin, določeni antikonvulzivi, itd.) teh presnovnih poti očistka zdravila lahko torej vsak zase zvišajo ali znižajo plazemske koncentracije posakonazola.
English: Co-administration may result in increased plasma concentrations of these medicinal products, leading to QTc prolongation and rare occurrences of torsades de pointes (see section 4.3).
Slovenian: Sočasna uporaba lahko povzroči povečanje plazemske koncentracije teh zdravil, kar bi vodilo do podaljšanja intervala QTc, redko pa tudi do pojava torsades de pointes (glejte poglavje 4.3).
English: • Rifabutin (used to treat certain infections)
Slovenian: • rifabutin (ki ga uporabljamo za zdravljenje določenih okužb)
English: Ciclosporin: In heart transplant patients on stable doses of ciclosporin, posaconazole 200 mg once daily increased ciclosporin concentrations requiring dose reductions.
Slovenian: Ciklosporin: Pri bolnikih s presajenim srcem na stalnih odmerkih ciklosporina je posakonazol v odmerku 200 mg enkrat na dan povečal koncentracijo ciklosporina, zaradi česar je bilo potrebno zmanjšanje njegovega odmerka.
English: Of the circulating metabolites, the majority are glucuronide conjugates of posaconazole with only minor amounts of oxidative (CYP450 mediated) metabolites observed.
Slovenian: Od presnovkov v krvi je večina glukuronidnih konjugatov posakonazola, opazili pa so le majhne količine oksidativnih presnovkov (presnova posredovana s CYP450).
English: Use in renal impairment: An effect of renal impairment on the pharmacokinetics of posaconazole is not expected and no dose adjustment is recommended (see section 5.2).
Slovenian: Uporaba pri ledvični okvari: Vpliva ledvične okvare na farmakokinetiko posakonazola ni pričakovati, zato ni priporočil za prilagajanje odmerkov (glejte poglavje 5.2).
English: A measuring spoon is provided with each bottle for measuring 2.5 and 5 ml doses of the oral suspension.
Slovenian: Vsaki steklenički je priložena odmerna žlička za odmerjanje 2,5 in 5 ml peroralne
English: See section 3 of this leaflet for more information on how to take the suspension.
Slovenian: Za dodatne informacije o jemanju suspenzije glejte poglavje 3 tega navodila.
English: HIV Protease Inhibitors: As HIV protease inhibitors are CYP3A4 substrates, it is expected that posaconazole will increase plasma levels of these antiretroviral agents.
Slovenian: Zaviralci proteaze HIV: Ker so zaviralci proteaze HIV substrati izoencima CYP3A4, lahko pričakujemo, da bo posakonazol povečal plazemsko koncentracijo teh protiretrovirusnih zdravil.
English: The safety profile in these patients < 18 years of age appears similar to the safety profile observed in adults.
Slovenian: Profil varnosti zdravila pri teh bolnikih, mlajših od 18 let, je videti podoben kot pri odraslih.
English: Initial treatment of Thrush On the first day of treatment take 200 mg (one 5 ml spoonful) once.
Slovenian: Začetno zdravljenje soora Prvi dan zdravljenja zaužijte enkrat 200 mg (eno 5 ml žličko).
English: Gender The pharmacokinetics of posaconazole are comparable in men and women.
Slovenian: Spol Farmakokinetika posakonazola pri ženskah je podobna kot pri moških.
English: A key secondary endpoint was the incidence of proven/probable IFIs at 100 days post-randomization.
Slovenian: Ključni sekundarni končni rezultat je bila incidenca dokazane oziroma verjetne IFI 100 dni po randomizaciji.
English: As a result, sirolimus trough concentrations that fall within the usual therapeutic range may result in sub-therapeutic levels.
Slovenian: Zaradi tega lahko najnižje koncentracije sirolimusa, ki sicer še sodijo v običajni razpon terapevtskih koncentracij, dejansko pomenijo koncentracije pod terapevtskimi vrednostmi.
English: primidone.
Slovenian: Tηλ.
English: Sulfonylureas: Glucose concentrations decreased in some healthy volunteers when glipizide was coadministered with posaconazole.
Slovenian: Sulfonilureje: Pri sočasni uporabi glipizida in posakonazola se je pri nekaterih zdravih prostovoljcih zmanjšala koncentracija glukoze.
English: • An abnormal heart rhythm tracing (ECG) that shows a problem called long QTc interval
Slovenian: • nenormalen zapis srčnega ritma (EKG), ki kaže motnjo, imenovano podaljšanje intervala
English: Coccidioidomycosis: 11 of 16 patients were successfully treated (at the end of treatment complete or partial resolution of signs and symptoms present at baseline) with posaconazole 800 mg/day in divided doses for a median of 296 days and up to 460 days.
Slovenian: Kokcidioidomikoza: 11 od 16 bolnikov je bilo uspešno zdravljenih (ob koncu zdravljenja popolna ali delna odprava znakov in simptomov, prisotnih na začetku) s posakonazolom 800 mg/dan v deljenih odmerkih v času (mediana vrednost) 296 dni in do 460 dni.
English: adrenal insufficiency, blood gonadotropin decreased
Slovenian: insuficienca nadledvične žleze, zmanjšane vrednosti gonadotropinov v krvi
English: Oral posaconazole 800 mg/day in divided doses was evaluated for the treatment of invasive aspergillosis in patients with disease refractory to amphotericin B (including liposomal formulations) or itraconazole or in patients who were intolerant of these medicinal products in a non-comparative salvage therapy trial.
Slovenian: Peroralni posakonazol 800 mg/dan v deljenih odmerkih so ovrednotili za zdravljenje invazivne aspergiloze pri bolnikih z boleznijo, odporno na amfotericin B (vključno z liposomskimi oblikami) ali itrakonazol ter pri bolnikih, ki niso prenašali teh zdravil v neprimerjalnem preskušanju zadnje možnosti terapije.
English: • Tacrolimus and sirolimus (used in transplant surgery)
Slovenian: • takrolimus in sirolimus (ki ju uporabljamo pri transplantacijah)
English: Adrenal suppressive effects were observed in toxicity studies in rats and dogs at exposures equal to or greater than those obtained at therapeutic doses in humans.
Slovenian: V študijah toksičnosti pri podganah in psih so opažali supresivne učinke na nadledvično žlezo pri izpostavljenostih, ki so bile enake ali večje od tistih, ki so jih dobili pri terapevtskih odmerkih pri človeku.
English: Chromoblastomycosis/Mycetoma: 9 of 11 patients were successfully treated with posaconazole 800 mg/day in divided doses for a median of 268 days and up to 377 days.
Slovenian: Kromoblastomikoza ali micetom: 9 od 11 bolnikov je bilo uspešno zdravljenih s posakonazolom 800 mg/dan v deljenih odmerkih v času (mediana vrednost) 268 dni in do 377 dni.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml of oral suspension contains 40 mg of posaconazole.
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Vsak ml peroralne suspenzije vsebuje 40 mg posakonazola.
English: In rabbits, posaconazole was embryotoxic at exposures greater than those obtained at therapeutic doses.
Slovenian: Pri kuncih je bil posakonazol embriotoksičen pri izpostavljenostih, večjih od tistih, ki so jih dobili pri terapevtskih odmerkih.
English: Study 316 was a randomised, double-blind trial of posaconazole oral suspension (200 mg three times a day) versus fluconazole capsules (400 mg once daily) in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease (GVHD).
Slovenian: Študija 316 je bila randomizirano, dvojno slepo preskušanje uporabe peroralne suspenzije posakonazola (200 mg trikrat na dan) v primerjavi s flukonazolom v kapsulah (400 mg enkrat na dan) pri prejemnikih alogenskega transplantata z boleznijo presadka proti gostitelju (GVHD).
English: Rifabutin (300 mg once a day) decreased the Cmax (maximum plasma concentration) and AUC (area under the plasma concentration time curve) of posaconazole to 57 % and 51 %, respectively.
Slovenian: Rifabutin (300 mg enkrat na dan) je zmanjšal Cmax (največjo plazemsko koncentracijo) posakonazola na 57 %, vrednost AUC za posakonazol (površino pod krivuljo plazemske koncentracije v odvisnosti od časa) pa na 51 %.
English: The effect of posaconazole on sirolimus in patients is unknown, but is expected to be variable due to the variable posaconazole exposure in patients.
Slovenian: Učinek posakonazola na sirolimus pri bolnikih ni znan, vendar lahko pričakujemo, da bo zaradi spremenljive stopnje izpostavljenosti posakonazolu tudi njegov učinek spremenljiv.
English: Posaconazole can increase the blood levels of these medicines, which can lead to very serious disturbances in heart rhythm:
Slovenian: če jemljete katerega od naslednjih zdravil - posakonazol lahko poveča koncentracijo teh zdravil v krvi, kar lahko vodi do zelo resnih motenj srčnega ritma:
English: PHARMACEUTICAL FORM Oral suspension
Slovenian: FARMACEVTSKA OBLIKA Peroralna suspenzija Bela suspenzija
English: Co-administration of posaconazole with CYP3A4 substrates may result in large increases in exposure to CYP3A4 substrates as exemplified by the effects on tacrolimus, sirolimus, atazanavir and midazolam below.
Slovenian: Sočasna uporaba posakonazola in substratov za CYP3A4 lahko povzroči veliko povečanje izpostavljenosti tem substratom, kar kažejo tudi ugotovljeni učinki na takrolimus, sirolimus, atazanavir in midazolam.
English: Concomitant use of posaconazole and rifabutin should be avoided unless the benefit to the patient outweighs the risk (see also above regarding the effect of rifabutin on plasma levels of posaconazole).
Slovenian: Izogibajte se sočasni uporabi posakonazola in rifabutina, razen če korist za bolnika odtehta tveganje (glejte zgoraj: Učinki rifabutina na plazemsko koncentracijo posakonazola).
English: What Posaconazole SP is and what it is used for 2.
Slovenian: Kaj je zdravilo Posaconazole SP in za kaj ga uporabljamo 2.
English: Posaconazole SP works by killing or stopping the growth of some types of fungi that can cause infections in humans.
Slovenian: Posaconazole SP deluje tako, da bodisi uniči nekatere vrste glivic, ki lahko povzročajo okužbe pri človeku, ali pa ustavi njihovo rast.
English: An increase in Cmax (26 %) and AUC (29 %) was observed in elderly subjects (24 subjects ≥ 65 years of age) relative to younger subjects (24 subjects 18 - 45 years of age).
Slovenian: Pri starostnikih (24 preiskovancev, starih ≥ 65 let) so opažali povečanje Cmax (26 %) in vrednosti AUC (29 %) v primerjavi z mlajšimi preiskovanci (24 preiskovancev, starih od 18 do 45 let).
English: Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine since this may result in increased plasma concentrations of these medicinal products, leading to QTc prolongation and rare occurrences of torsades de pointes (see sections 4.4 and 4.5).
Slovenian: Sočasna uporaba s substrati CYP3A4 terfenadinom, astemizolom, cisapridom, pimozidom, halofantrinom ali kinidinom, ker lahko povzroči povečanje plazemskih koncentracij teh zdravil, kar bi vodilo do podaljšanja intervala QTc, redko pa tudi do pojava torsades de pointes (glejte poglavji 4.4 in
English: Certain medicines may increase (possibly increasing the risk of side effects) or decrease (possibly causing lack of effectiveness) the blood levels of posaconazole.
Slovenian: Nekatera zdravila lahko povečajo koncentracijo posakonazola v krvi (in lahko torej povečajo tudi tveganje za neželene učinke) ali pa jo zmanjšajo (in lahko tudi zmanjšajo učinkovitost zdravila).
English: In addition, oral posaconazole (200 mg or 400 mg) prolonged the mean terminal half-life of midazolam from approximately 3-4 hours to 810 hours during co-administration.
Slovenian: Poleg tega je med sočasno uporabo peroralno zaužit posakonazol (v 200-mg ali 400-mg odmerku) podaljšal srednjo končno razpolovno dobo midazolama s približno 3 do 4 ure na 8 do 10 ur.
English: Medicines that can decrease blood levels of posaconazole include:
Slovenian: Med zdravila, ki lahko zmanjšajo koncentracijo posakonazola v krvi, sodijo:
English: Caution should be used when prescribing Posaconazole SP to patients with hypersensitivity to other azoles.
Slovenian: Pri predpisovanju zdravila Posaconazole SP bolnikom, ki so preobčutljivi za druge azole, je potrebna previdnost.
English: Posaconazole should be administered with food or a nutritional supplement (see section 4.2).
Slovenian: Posakonazol naj bi bolniki jemali s hrano ali s prehranskim dodatkom (glejte poglavje 4.2).
English: As observed with other azole antifungal agents, effects related to inhibition of steroid hormone synthesis were seen in repeated-dose toxicity studies with posaconazole.
Slovenian: Kot so opažali tudi pri drugih azolskih antimikotikih, so v študijah toksičnosti večkratnih odmerkov s posakonazolom videli učinke, povezane z zavoro sinteze steroidnih hormonov.
English: 1 Includes other less common species or species unknown
Slovenian: 1 Vključuje druge manj pogoste vrste ali neznane vrste randomizaciji, kar je ugotavljala neodvisna komisija zunanjih strokovnjakov na slep način.
English: Results from clinical studies in prophylaxis of Invasive Fungal Infections.
Slovenian: Izsledki kliničnih študij profilakse invazivnih glivičnih okužb Študija
English: liver function tests raised (ALT increased, AST increased, bilirubin increased, alkaline phosphatase increased, GGT increased) hepatocellular damage*, hepatitis, jaundice, hepatomegaly hepatic failure, hepatitis cholestatic, cholestasis,
Slovenian: zvišani testi delovanja jeter (zvišan ALT, zvišan AST, zvišan bilirubin, zvišana alkalna fosfataza, zvišan GGT) hepatocelularne poškodbe*, hepatitis, zlatenica, hepatomegalija jetrna odpoved, holestatski hepatitis, holestaza, hepatosplenomegalija, občutljivost jeter, asteriksis
English: long QT syndrome§, electrocardiogram abnormal§, palpitations torsade de pointes, sudden death, ventricular tachycardia, cardio-respiratory arrest, cardiac failure, myocardial infarction
Slovenian: §, nenormalen elektrokardiogram§, palpitacije torsades de pointes, nenadna smrt, ventrikularna tahikardija, zastoj srca in dihanja, srčna odpoved, miokardni infarkt
English: Study 1899 was a randomised, evaluator-blinded study of posaconazole oral suspension (200 mg three times a day) versus fluconazole suspension (400 mg once daily) or itraconazole oral solution (200 mg twice a day) in neutropenic patients who were receiving cytotoxic chemotherapy for acute myelogenous leukemia or myelodysplastic syndromes.
Slovenian: Študija 1899 je bila randomizirana, za ocenjevalce slepa študija uporabe peroralne suspenzije posakonazola (200 mg trikrat na dan) v primerjavi s suspenzijo flukonazola (400 mg enkrat na dan) ali peroralno raztopino itrakonazola (200 mg dvakrat na dan) pri bolnikih z nevtropenijo, ki so prejemali citotoksično kemoterapijo zaradi akutne mieloične levkemije ali mielodisplastičnih sindromov.
English: Clinical success rates in Oropharyngeal Candidiasis Endpoint
Slovenian: Klinična uspešnost pri orofaringealni kandidiazi Končni rezultat
English: Midazolam and other benzodiazepines metabolised by CYP3A4: In a study in healthy volunteers posaconazole (200 mg once daily for 10 days) increased the exposure (AUC) of IV midazolam (0.05 mg/kg) by 83 %.
Slovenian: Midazolam in ostali benzodiazepini, ki se presnovijo s CYP3A4: V študiji pri zdravih prostovoljcih je posakonazol (v odmerku 200 mg enkrat na dan 10 dni) povečal izpostavljenost (t.j.
English: You should not take this medicine if you have a condition called glucose-galactose malabsorption and should take note of this amount of glucose if you need to watch your sugar intake for any reason.
Slovenian: To količino glukoze tudi upoštevajte, če morate iz kakršnegakoli razloga paziti na vnos sladkorja.
English: Treatment with these HMG-CoA reductase inhibitors should be discontinued during treatment with posaconazole as increased levels have been associated with rhabdomyolysis (see section 4.3).
Slovenian: Pri sočasni uporabi posakonazola z zaviralci HMG-CoA reduktaze je potrebno zdravljenje prekiniti, ker so bile zvišane koncentracije povezane z rabdomiolizo (glejte poglavje 4.3).
English: Prophylaxis of Invasive Fungal Infections
Slovenian: Profilaksa invazivnih glivičnih okužb
English: Please look at the list of medicines that must not be taken while you are taking Posaconazole SP that is given above.
Slovenian: Preberite zgornji seznam zdravil, ki jih ne smete jemati med zdravljenjem z zdravilom Posaconazole SP.
English: Cases of elevated ciclosporin levels resulting in serious adverse events, including nephrotoxicity and one fatal case of leukoencephalopathy, were reported in clinical efficacy studies.
Slovenian: V študijah klinične učinkovitosti so poročali o primerih zvišane koncentracije ciklosporina, ki je vodila do resnih neželenih pojavov, vključno z nefrotoksičnostjo in enim smrtnim primerom levkoencefalopatije.
English: acute renal failure, renal failure, blood creatinine increased renal tubular acidosis, interstitial nephritis
Slovenian: akutna ledvična odpoved, ledvična odpoved, zvišana vrednost kreatinina v krvi, renalna tubularna acidoza, intersticijski nefritis
English: Both doses of posaconazole increased Cmax and AUC of oral midazolam (2 mg single oral dose) by 2.2 and 4.5-fold, respectively.
Slovenian: Oba odmerka posakonazola sta povečala vrednost Cmax za peroralno zaužit midazolam (2-mg enkratni peroralni odmerek) za 2,2-krat, vrednost AUC pa za 4,5-krat.
English: paresthesia, dizziness, somnolence, headache convulsion, neuropathy, hypoaesthesia, tremor cerebrovascular accident, encephalopathy, peripheral neuropathy, syncope
Slovenian: parestezije, omotica, somnolenca, glavobol konvulzije, nevropatija, hipestezija, tremor cerebrovaskularni insult, encefalopatija, periferna nevropatija, sinkopa
English: Each dose of Posaconazole SP should be taken with food or a nutritional supplement if you are unable to tolerate food to enhance the oral absorption.
Slovenian: Jemanje zdravila Posaconazole SP skupaj s hrano in pijačo Vsak odmerek zdravila Posaconazole SP vzemite s hrano, če ne prenašate hrane pa s prehranskim dodatkom, da bi povečali peroralno absorpcijo zdravila.
English: Tacrolimus: Posaconazole increased Cmax and AUC of tacrolimus (0.05 mg/kg body weight single dose) by 121 % and 358 %, respectively.
Slovenian: Takrolimus: Posakonazol je povečal Cmax takrolimusa za 121 %, vrednost AUC za takrolimus pa za 358 % (enkratni odmerek 0,05 mg/kg telesne mase).
English: HMG-CoA reductase inhibitors metabolised through CYP3A4 (e.g. simvastatin, lovastatin, and atorvastatin): Posaconazole may substantially increase plasma levels of HMG-CoA reductase inhibitors that are metabolised by CYP3A4.
Slovenian: Zaviralci HMG-CoA reduktaze, ki se presnovijo s CYP3A4 (npr. simvastatin, lovastatin in atorvastatin): Posakonazol lako bistveno poveča plazemske koncentracije zaviralcev HMG-CoA reduktaze, ki se presnovijo s CYP3A4.
English: Caution is advised during coadministration of posaconazole with CYP3A4 substrates administered intravenously and the dose of the CYP3A4 substrate may need to be reduced.
Slovenian: Med sočasno uporabo posakonazola in intravensko danih substratov CYP3A4 svetujemo previdnost in lahko bo tudi potrebno zmanjšanje odmerka substrata CYP3A4.
English: If co-administered, then it is recommended that dose adjustment of vinca alkaloids be considered.
Slovenian: Če pa ta zdravila kljub temu uporabljate sočasno, priporočamo, da po potrebi prilagodite odmerek vinka alkaloidov.
English: c: In 1899, this was the period from randomization to 100 days post-randomization; in 316 it was the period from the baseline day to 111 days post-baseline.
Slovenian: V študiji 1899 je bilo to obdobje od randomizacije do 100. dne po randomizaciji, v študiji 316 pa od začetka študije do 111. dne po začetku študije.
English: Calcium channel blockers metabolised through CYP3A4 (e.g. diltiazem, verapamil, nifedipine, nisoldipine): Frequent monitoring for adverse events and toxicity related to calcium channel blockers is recommended during co-administration with posaconazole.
Slovenian: Zaviralci kalcijevih kanalov, ki se presnovijo s CYP3A4 (npr. diltiazem, verapamil, nifedipin, nisoldipin): Med sočasno uporabo s posakonazolom je priporočljivo pogosto spremljanje za ugotovitev neželenih sopojavov in toksičnosti v zvezi z zaviralci kalcijevih kanalov.
English: • Digoxin (used to treat heart failure)
Slovenian: • digoksin (in ga uporabljamo za zdravljenje srčnega popuščanja)
English: Clinically significant interactions resulting in hospitalisation and/or posaconazole discontinuation were reported in clinical efficacy studies.
Slovenian: V študijah klinične učinkovitosti so poročali o klinično pomembnih interakcijah, ki so zahtevale hospitalizacijo in/ali ukinitev posakonazola.
English: rash mouth ulceration, alopecia Stevens Johnson syndrome, vesicular rash
Slovenian: izpuščaj razjede v ustih, alopecija Stevens-Johnsonov sindrom, vezikulozni izpuščaj
English: Infections (IFI)/Intolerant patients with IFI
Slovenian: Priporočeno odmerjanje glede na indikacijo glivične okužbe (IFI) ali bolniki, ki ne prenašajo zdravila in imajo IFI
English: Posaconazole SP may increase (possibly increasing the risk of side effects) the blood levels of some other medicines.
Slovenian: Tudi Posaconazole SP lahko poveča koncentracijo nekaterih drugih zdravil v krvi (in lahko torej poveča tudi tveganje za njihove neželene učinke).
English: Efavirenz (400 mg once a day) decreased the Cmax and AUC of posaconazole by 45 % and 50 %, respectively.
Slovenian: Efavirenz (v odmerku 400 mg enkrat na dan) je zmanjšal vrednost Cmax za posakonazol za 45 %, vrednost AUC pa za 50 %.
English: Due to the risk of prolonged sedation it is recommended that dose adjustments should be considered when posaconazole is administered concomitantly with any benzodiazepine that is metabolised by CYP3A4 (e.g. midazolam, triazolam, alprazolam).
Slovenian: Zaradi tveganja za dolgotrajnejšo sedacijo priporočamo, da pri sočasni uporabi posakonazola in kateregakoli benzodiazepina, ki se presnavlja z izoencimom CYP3A4 (npr. midazolama, triazolama ali alprazolama), po potrebi prilagodite odmerjanje.
English: Based on Kaplan-Meier estimates, the probability of survival up to day 100 after randomization, was significantly higher for posaconazole recipients; this survival benefit was demonstrated when the analysis considered all causes of death (P= 0.0354) as well as IFI-related deaths (P = 0.0209).
Slovenian: Ta koristen vpliv na stopnjo preživetja so pokazali, ko so v analizi upoštevali vse vzroke smrti (p= 0,0354), pa tudi smrti, povezane z IFI (p = 0,0209).
English: thrombocytopenia, leukopenia, anaemia, eosinophilia, lymphadenopathy haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura, pancytopenia, coagulopathy, haemorrhage
Slovenian: nevtropenija trombocitopenija, levkopenija, anemija, eozinofilija, limfadenopatija hemolitično uremični sindrom, trombotična trombocitopenična purpura, pancitopenija, koagulopatija, krvavitve