FrancophonIA/ELRC3.0 huggingface dataset:
English: In clinical studies of treatment-experienced patients receiving raltegravir, rash, irrespective of causality, was more commonly observed with regimens containing raltegravir and darunavir compared to those containing raltegravir without darunavir or darunavir without raltegravir.
Croatian: U kliničkim ispitivanjima u prethodno liječenih bolesnika koji su primali raltegravir osip je, bez obzira na uzrok, češće zapažen u bolesnika čija je terapija uključivala raltegravir i darunavir nego u onih koji su primali raltegravir bez darunavira ili darunavir bez raltegravira.
English: Your doctor may decide to change your dose by using the medicines in DUTREBIS separately, if you are taking rifampicin.
Croatian: Vaš liječnik će možda odlučiti promijeniti doziranje lijeka tako što će Vam lijekove sadržane u lijeku DUTREBIS davati odvojeno.
English: Multiple drug antiretroviral therapy containing lamivudine has been shown to be effective in antiretrovirally-naive patients as well as in patients presenting with viruses containing the M184V
Croatian: Višestruka antiretrovirusna terapija koja sadrži lamivudin pokazala se djelotvornom u bolesnika koji prethodno nisu primali antiretrovirusne lijekove kao i u bolesnika kojima su izolirani virusi s mutacijama M184V.
English: Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take:
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako uzimate ili ste nedavno uzeli ili biste mogli uzeti:
English: Based on data derived from a study in healthy volunteers, at a therapeutic dose of 150 mg twice daily, mean (CV) steady-state Cmax and Cmin of lamivudine in plasma are 1.2 μg/ml (24 %) and 0.09 μg/ml (27 %), respectively.
Croatian: Na temelju podataka iz ispitivanja u zdravih dobrovoljaca, pri terapijskoj dozi od 150 mg dvaput na dan, srednja vrijednost (CV) u stanju dinamičke ravnoteže Cmax i Cmin lamivudina u plazmi iznose 1,2 µg/ml (24%), odnosno 0,09 µg/ml (27%).
English: DUTREBIS is not recommended for use in combination with emtricitabine containing products, since both lamivudine (in DUTREBIS) and emtricitabine are cytidine analogues (i.e. risk for intracellular interactions, (see section 4.4).
Croatian: Ne preporučuje se primjena lijeka DUTREBIS u kombinaciji s lijekovima koji sadrže emtricitabin jer su i lamivudin (u lijeku DUTREBIS) i emtricitabin analozi citidina (tj. postoji rizik od unutarstaničnih interakcija, vidjeti dio 4.4).
English: Hypersensitivity reactions have also been reported and were characterized by rash, constitutional findings, and sometimes, organ dysfunction, including hepatic failure.
Croatian: Prijavljene su također i reakcije preosjetljivosti obilježene osipom, sustavnim simptomima i ponekad disfunkcijom pojedinih organa, uključujući i zatajenje jetre.
English: DUTREBIS is indicated in combination with other anti-retroviral medicinal products for the treatment of human immunodeficiency virus (HIV-1) infection in adults, adolescents, and children from the age of 6 years and weighing at least 30 kg without present or past evidence of viral resistance to antiviral agents of the InSTI (Integrase Strand Transfer Inhibitor) and NRTI (Nucleoside Reverse Transcriptase Inhibitor) classes (see sections 4.2, 4.4 and 5.1).
Croatian: DUTREBIS je u kombinaciji s drugim antiretrovirusnim lijekovima indiciran za liječenje infekcije virusom humane imunodeficijencije (HIV-1) u odraslih, adolescenata i djece od navršenih 6 godina života i tjelesne težine najmanje 30 kg bez trenutnih ili ranijih znakova virusne rezistencije na antivirusne lijekove iz skupine inhibitora prijenosa lanca integraze (engl. integrase strand transfer inhibitor, InSTI) i nukleozidnih inhibitora reverzne transkriptaze (engl. nucleoside reverse transcriptase inhibitor, NRTI) (vidjeti dijelove 4.2, 4.4 i 5.1).
English: tipranavir /ritonavir /lamivudine Interaction not studied
Croatian: tipranavir/ritonavir/lamivudin Interakcija nije ispitana.
English: • kidney stones; urination at night; kidney cyst
Croatian: • bubrežni kamenci; mokrenje noću; bubrežna cista
English: A higher risk of lipodystrophy has been associated with individual factors such as older age, and with drug related factors such as longer duration of ART and associated metabolic disturbances.
Croatian: Povećan rizik od lipodistrofije povezuje se s čimbenicima koji se odnose na pojedinca, poput starije dobi, zatim s čimbenicima povezanima s primjenom lijeka, poput trajanja antiretrovirusne terapije, kao i s pridruženim metaboličkim poremećajima.
English: If this is noticed later than 6 hours of the time it is usually taken, the missed dose should not be taken and the patient should resume the usual dosing schedule.
Croatian: Ako bolesnik primijeti da je propustio uzeti dozu više od 6 sati nakon uobičajenog vremena uzimanja, propuštenu dozu ne smije uzeti, nego treba nastaviti s primjenom prema uobičajenom rasporedu.
English: • fat may be lost from the legs, arms or face; extra fat may build up around the tummy, breasts or internal organs; fatty lumps (sometimes called buffalo hump) may appear on the back of the neck.
Croatian: • možete izgubiti masno tkivo s nogu, ruku ili lica; masno tkivo može se početi dodatno nakupljati na trbuhu, na grudima ili oko unutarnjih organa; mogu se pojaviti masne nakupine na zatiljku (ponekad se to naziva bivoljom grbom).
English: In some studies, co-administration of raltegravir with darunavir resulted in a modest decrease in darunavir plasma concentrations; the mechanism for this effect is unknown.
Croatian: U nekim je ispitivanjima istodobna primjena raltegravira i darunavira dovela do blagog sniženja koncentracija darunavira u plazmi; mehanizam tog učinka nije poznat.
English: • muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity.
Croatian: • slabosti mišića, slabosti koja počinje u šakama i stopalima i podiže se prema trupu tijela, osjećaj lupanja srca, nevoljno drhtanje ili hiperaktivnost.
English: • Lamivudine belongs to a group of medicines called nucleoside analogue reverse transcriptase
Croatian: • Lamivudin pripada skupini lijekova koji se zovu nukleozidni analozi inhibitora reverzne
English: Merck Sharp & Dohme Ireland (Human Health)
Croatian: Merck Sharp & Dohme Ireland (Human Health) Limited
English: Tell your doctor immediately if you have any of the following signs of lactic acidosis, or any other
Croatian: Odmah obavijestite svog liječnika ako primijetite bilo koji od sljedećih znakova laktacidoze ili bilo koje druge simptome koji Vas zabrinjavaju:
English: No human data on the effect of DUTREBIS on fertility are available.
Croatian: Nema podataka o učinku lijeka DUTREBIS na plodnost ljudi.
English: For each of the following clinical adverse reactions reported for raltegravir there was at least one serious occurrence: genital herpes, anaemia, immune reconstitution syndrome, depression, mental disorder, suicide attempt, gastritis, hepatitis, renal failure, accidental overdose.
Croatian: Zabilježen je najmanje jedan ozbiljan slučaj za svaku od sljedećih kliničkih nuspojava prijavljenih pri primjeni raltegravira: genitalni herpes, anemiju, sindrom imunološke rekonstitucije, depresiju, mentalni poremećaj, pokušaj suicida, gastritis, hepatitis, zatajenje bubrega, slučajno predoziranje.
English: This enzyme is needed for HIV to make more virus.
Croatian: Taj je enzim potreban virusu HIV-a da bi se mogao umnažati.
English: In a drug interaction study with DUTREBIS and etravirine, there was no clinically meaningful drug interaction between raltegravir and etravirine, with respect to raltegravir.
Croatian: U ispitivanju interakcija lijeka DUTREBIS i etravirina nije zabilježena klinički značajna interakcija između raltegravira i etravirina koja bi utjecala na raltegravir.
English: • Lactic acidosis is more likely to happen in people who have liver problems, or in people who
Croatian: • Veća je vjerojatnost da će se laktacidoza razviti u osoba koje imaju tegobe s jetrom ili u osoba koje imaju znatno prekomjernu tjelesnu težinu, osobito u žena.
English: The side effects for the two individual medicines contained in DUTREBIS are presented below.
Croatian: Nuspojave primijećene pri primjeni tih dvaju pojedinačnih lijekova sadržanih u lijeku DUTREBIS navedene su u nastavku.
English: These neoplasia could result from local deposition and/or aspiration of drug on the mucosa of the nose/nasopharynx during oral gavage dosing and subsequent chronic irritation and inflammation; it is likely that they are of limited relevance for the intended clinical use.
Croatian: Te su novotvorine mogle nastati zbog aspiracije i/ili lokalnog nakupljanja lijeka na sluznici nosa/nazofarinksa tijekom izravne primjene lijeka putem sonde i posljedične kronične iritacije i upale.
English: A transplacental genotoxicity study conducted in monkeys compared zidovudine alone with the combination of zidovudine and lamivudine at human-equivalent exposures.
Croatian: U ispitivanjima transplacentalne genotoksičnosti na majmunima uspoređivala se primjena samog zidovudina i zidovudina u kombinaciji s lamivudinom pri razinama izloženosti ekvivalentnima izloženosti u ljudi.
English: Autoimmune disorders (such as Graves' disease) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Croatian: U okolnostima imune reaktivacije prijavljena je i pojava autoimunih poremećaja (primjerice Gravesova bolest); međutim, prijavljeno vrijeme do nastupa je različito i ti se događaji mogu javiti više mjeseci nakon uvođenja liječenja (vidjeti dio 4.4).
English: • trimethoprim - used to treat infections.
Croatian: • trimetoprim - koristi se za liječenje infekcija.
English: The relationship between in vitro susceptibility of HIV to lamivudine and clinical response to lamivudine-containing therapy remains under investigation.
Croatian: I dalje se ispituje odnos između osjetljivosti HIV-a na lamivudin in vitro i kliničkog odgovora na terapiju koja sadržava lamivudin.
English: Because lamivudine is substantially excreted by the kidney and older people are more likely to have decreased renal function, renal function should be monitored.
Croatian: Budući da se lamivudin u znatnoj mjeri izlučuje putem bubrega, a vjerojatnije je da će u starijih osoba funkcija bubrega biti smanjena, potrebno je nadzirati funkciju bubrega.
English: The NRTIs (e.g. didanosine, zidovudine) are not eliminated by this mechanism and are unlikely to interact with lamivudine.
Croatian: NRTI (didanozin, zidovudin) se ne eliminiraju ovim mehanizmom pa interakcija s lamivudinom nije vjerojatna.
English: No dosage adjustment is necessary when these agents are given together.
Croatian: Nije potrebno prilagođavati dozu kada se ovi lijekovi primjenjuju istodobno.
English: • DUTREBIS is not recommended in pregnancy.
Croatian: • Primjena lijeka DUTREBIS u trudnoći se ne preporučuje.
English: It is not known whether raltegravir is secreted in human milk.
Croatian: Nije poznato izlučuje li se raltegravir u majčino mlijeko u ljudi.
English: • low count of white blood cells that fight infection; pain or swollen glands (lymph nodes) in the neck, armpit and groin
Croatian: • snižen broj bijelih krvnih stanica koje se bore protiv infekcije; bol ili otečene žlijezde (limfni čvorovi) na vratu, pazuhu i preponama
English: Talk to your doctor, pharmacist or nurse before taking DUTREBIS if:
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete DUTREBIS:
English: In rats, tumours (squamous cell carcinoma) of the nose/nasopharynx were identified at 300 and 600 mg/kg/day in females and at 300 mg/kg/day in males.
Croatian: Kod štakora su utvrđeni tumori (planocelularni karcinom) nosa/nazofarinksa, i to pri primjeni doza od 300 i 600 mg/kg/dan kod ženki te 300 mg/kg na dan kod mužjaka.
English: DUTREBIS is an antiretroviral medicine used to treat infection with human immunodeficiency virus (HIV).
Croatian: DUTREBIS je antiretrovirusni lijek koji se koristi za liječenje infekcije virusom humane imunodeficijencije (HIV).
English: Limited data are available on the consequences of ingestion of acute overdoses in humans.
Croatian: Podaci o posljedicama akutnog predoziranja u ljudi su ograničeni.
English: The Genotypic Sensitivity Score (GSS) was defined as the total oral ARTs in the optimised background therapy (OBT) to which a patient's viral isolate showed genotypic sensitivity based upon genotypic resistance test. Enfuvirtide use in OBT in enfuvirtide-naïve patients was counted as one active drug in OBT.
Croatian: Indeks genotipske osjetljivosti (GSS) definiran je kao ukupan broj peroralnih ART-a obuhvaćenih optimiziranom osnovnom terapijom (OBT-om) na koje je izolat virusa pojedinog bolesnika iskazao genotipsku osjetljivost na temelju genotipskog testa rezistencije.
English: • infection of the hair roots; influenza; skin infection due to virus; upper respiratory tract infection(such as inflammation of the nasal cavity or sinuses located around the nose; common cold); infection in the lymph node (gland in the neck, armpit, or groin)
Croatian: • infekcija korijena dlake; gripa; kožne infekcije uzrokovane virusom; infekcija gornjih dišnih puteva (kao što je upala nosne šupljine ili sinusa u području nosa; prehlada); infekcija u limfnom čvoru (žlijezda u vratu, pazuhu ili preponama)
English: If you are not sure, talk to your doctor, pharmacist or nurse before taking DUTREBIS.
Croatian: Ako niste sigurni, obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete DUTREBIS.
English: Raltegravir achieved virologic responses (using Not Completer=Failure approach) of HIV RNA < 50 copies/ml in 61.7 % of patients at Week 16, in 62.1 % at Week 48 and in 57.0 % at Week 96.
Croatian: Virološki odgovor na raltegravir od < 50 HIV-RNK kopija/ml (primjena pristupa "prerani prekid = neuspjelo liječenje") postignut je u 61,7% bolesnika nakon 16 tjedana, u 62,1% bolesnika nakon 48 tjedana i u 57,0% bolesnika nakon 96 tjedana liječenja.
English: Pharmacokinetic Interaction Data between the Individual Components of DUTREBIS and
Croatian: Podaci o farmakokinetičkim interakcijama između pojedinačnih komponenti lijeka DUTREBIS
English: Viruses harbouring a mutation at amino acid 148, along with one or more other raltegravir resistance mutations, may also have clinically
Croatian: Virusi koji nose mutaciju na aminokiselini 148 te jednu ili više mutacija koje uzrokuju rezistenciju na raltegravir, mogli bi imati i klinički značajnu rezistenciju na dolutegravir.
English: The most common adverse reactions reported during treatment with lamivudine are headache, nausea, malaise, fatigue, nasal signs and symptoms, diarrhoea and cough.
Croatian: Najčešće nuspojave prijavljene tijekom liječenja lamivudinom su glavobolja, mučnina, malaksalost, umor, nazalni znakovi i simptomi, proljev i kašalj.
English: DUTREBIS 150 mg/300 mg film-coated tablets lamivudine/raltegravir
Croatian: DUTREBIS 150 mg/300 mg filmom obložene tablete lamivudin/raltegravir
English: Factors that reduced the likelihood of developing resistance included lower baseline viral load and use of other active anti-retroviral agents.
Croatian: Faktori koji umanjuju vjerojatnost za razvoj rezistencije uključuju manje početno virusno opterećenje i primjenu drugih antiretrovirusnih lijekova.
English: Co-administration of raltegravir with a calcium carbonate antacid decreased raltegravir plasma levels; however, this interaction is not considered clinically meaningful.
Croatian: Istodobna primjena raltegravira s antacidom koji sadrži kalcijev karbonat snizila je koncentraciju raltegravira u plazmi; međutim, ta se interakcija ne smatra klinički značajnom.
English: The extent to which raltegravir may be dialysable is unknown.
Croatian: Nije poznato do koje se mjere raltegravir može odstraniti dijalizom.
English: Raltegravir C12 hr increases dose proportionally over the dose range of 100 to 800 mg and increases slightly less than dose proportionally over the dose range 100 mg to 1,600 mg.
Croatian: Proporcionalno dozi povećava se i C12h raltegravira u rasponu doza od 100 mg do 800 mg, dok je u rasponu doza od 100 mg do 1600 mg taj porast nešto manji od proporcionalnog.
English: At a therapeutic dose of 300 mg once daily, the mean (CV) steady-state Cmax, Cmin and 24h AUC are 2.0 μg/ml (26 %), 0.04 μg/ml (34 %) and 8.9 μg•h/ml (21 %), respectively.
Croatian: Pri terapijskoj dozi od 300 mg jedanput na dan, srednja vrijednost (CV) u stanju dinamičke ravnoteže Cmax iznosi 2,0 µg/ml (26%), Cmin iznosi 0,04 µg/ml (34%), a 24-satni AUC 8,9 µg•h/ml (21%).
English: This may be more likely with long-term HIV treatment, more severe damage to the immune system, overweight, or the use of alcohol or other medicines called corticosteroids.
Croatian: Vjerojatnost za to mogla bi biti veća u slučaju dugotrajnog liječenja HIV-a, težih oštećenja imunološkog sustava, prekomjerne tjelesne težine, konzumacije alkohola ili primjene drugih lijekova koji se
English: In vitro studies indicate that zidovudine-resistant virus isolates can become zidovudine sensitive when they simultaneously acquire resistance to lamivudine.
Croatian: Ispitivanja in vitro pokazuju da izolati virusa rezistentni na zidovudin mogu postati osjetljivi na zidovudin istodobno kada postanu rezistentni na lamivudin.
English: 119 cells/mm
Croatian: 119 stanica/mm
English: The bioavailablity of the raltegravir component of DUTREBIS in the fasted state is approximately 60 %, which is higher than the bioavailability of raltegravir in the raltegravir poloxamer formulation, and accounts for the difference in raltegravir dose.
Croatian: Bioraspoloživost komponente raltegravira u lijeku DUTREBIS nakon primjene natašte iznosi približno 60%, što je više od bioraspoloživosti raltegravira u formulaciji s poloksamerom i objašnjava razliku u dozi raltegravira.
English: Some people taking DUTREBIS, or similar medicines, may get a side effect called “lactic acidosis” and a swollen liver.
Croatian: U nekih ljudi koji uzimaju DUTREBIS ili slične lijekove može se razviti nuspojava koja se zove "laktacidoza", a prati je oticanje jetre.
English: The evidence of efficacy of raltegravir was based on the analyses of 96-week data from two randomised, double-blind, placebo-controlled studies, (BENCHMRK 1 and BENCHMRK 2, Protocols 018 and 019) in antiretroviral treatment-experienced HIV-1 infected adult patients and the analysis of 240-week data from randomised, double-blind, active-control trial, (STARTMRK, Protocol 021) in antiretroviral treatment-naïve HIV-1 infected adult patients.
Croatian: Dokazi djelotvornosti raltegravira temeljili su se na analizama podataka nakon 96 tjedana iz dva randomizirana, dvostruko slijepa, placebom kontrolirana ispitivanja (BENCHMRK 1 i BENCHMRK 2, protokoli 018 i 019) u odraslih bolesnika inficiranih virusom HIV-1 koji su prethodno liječeni antiretrovirusnim lijekovima te na analizi podataka prikupljenih nakon 240 tjedana randomiziranog, dvostruko slijepog, aktivnim lijekom-komparatorom kontroliranog ispitivanja (STARTMRK, Protokol 021) u odraslih bolesnika inficiranih virusom HIV-1 koji prethodno nisu bili liječeni antiretrovirusnim lijekovima.
English: Raltegravir readily crossed the placenta in rats, but did not penetrate the brain to any appreciable extent.
Croatian: Raltegravir s lakoćom prolazi kroz placentu štakorica, ali ne prolazi u značajnijoj mjeri u mozak.
English: Patients with pre-existing liver dysfunction including chronic hepatitis have an increased frequency of liver function abnormalities during CART and should be monitored according to standard practice.
Croatian: U bolesnika s već postojećom disfunkcijom jetre, uključujući kronični hepatitis, su tijekom kombinirane antiretrovirusne terapije učestaliji poremećaji funkcije jetre te ih stoga treba nadzirati u skladu sa standardnom praksom.
English: The clinically relevant effects noted were a reduction in red blood cell count and neutropenia.
Croatian: Zabilježeni klinički značajni učinci bili su smanjenje broja eritrocita i neutropenija.
English: Raltegravir was administered with an optimized background regimen.
Croatian: Raltegravir se primjenjivao s optimiziranom
English: Similarly, darunavir use in OBT in darunavir-naïve patients was counted as one active drug in OBT.
Croatian: Slično tomu, darunavir primijenjen kao dio OBT-a u bolesnika koji ga prije nisu primali računao se kao jedan aktivan lijek u sklopu OBT-a.
English: The mean ratio CSF/serum lamivudine concentration 2-4 hours after oral administration was approximately 0.12.
Croatian: Srednji omjer koncentracija lamivudina u cerebrospinalnoj tekućini i serumu 2 do 4 sata nakon peroralne primjene iznosi oko 0,12.
English: Baseline Characteristics and Efficacy Outcomes at Weeks 24 and 48 from IMPAACT P1066
Croatian: Tablica 4 Početne karakteristike bolesnika i ishodi djelotvornosti u 24. i 48. tjednu iz ispitivanja IMPAACT P1066 (bolesnici u dobi od 2 do 18 godina)
English: Prior to randomization, OBT were selected by the investigator based on the patient's prior treatment history, as well as baseline genotypic and phenotypic viral resistance testing.
Croatian: Prije randomizacije ispitivač je svakom bolesniku odredio OBT na temelju prethodnog liječenja i rezultata početnih genotipskih i fenotipskih testova rezistencije virusa.
English: It also lowers the chance that your medicines will stop being able to fight HIV (also called "drug resistance").
Croatian: Time možete poboljšati djelovanje lijekova te umanjiti mogućnost da lijekovi koje uzimate postanu nedjelotvorni protiv HIV-a (to se naziva i "otpornost na lijek").
English: Factors associated with failure include high baseline viral load and OBT that did not include at least one potent active agent.
Croatian: Faktori povezani s neuspješnim odgovorom na liječenje uključuju visoko virusno opterećenje na početku liječenja i OBT u koju nije uključen najmanje jedan potentni aktivni lijek.
English: In adults, there were no clinically important pharmacokinetic differences between patients with moderate hepatic insufficiency and healthy subjects.
Croatian: U odraslih nisu zabilježene klinički značajne razlike u farmakokinetici lijeka između bolesnika s umjerenom insuficijencijom jetre i zdravih ispitanika.
English: Some patients experienced viral rebound between Week 16 and Week 96.
Croatian: U nekih je bolesnika između 16. i 96. tjedna došlo do ponovnog porasta virusnog opterećenja.
English: This does not require dose adjustment unless the patient also has renal impairment (see sections 4.5 and 4.2).
Croatian: To ne zahtijeva prilagođavanje doze ako bolesnik istodobno nema oštećenu funkciju bubrega (vidjeti dijelove 4.5 i 4.2).
English: Cross-resistance conferred by the M184V RT is limited within the nucleoside inhibitor class of antiretroviral agents.
Croatian: Križna rezistencija koju prenosi mutacija reverzne transkriptaze M184V ograničena je na skupinu antiretrovirusnih lijekova koji su nukleozidni inhibitori.
English: • loss of memory; pain in the hand due to nerve compression; disturbance in attention; dizziness with rapid changes in posture; abnormal taste; increased sleepiness; lack of energy; forgetfulness; migraine headache; reduced sense of touch, numbness or weakness of the arms and/or legs; tingling; sleepiness; tension headache; tremors; poor quality sleep
Croatian: • gubitak pamćenja; bol u šaci zbog pritiska na živac; poremećaj pažnje; omaglica kod naglih promjena položaja tijela; promijenjen osjet okusa; povećana pospanost; nedostatak energije; zaboravljivost; migrena; smanjen osjet dodira, utrnulost ili slabost u rukama i/ili nogama; trnci; pospanost; tenzijska glavobolja; nevoljno drhtanje (tremor); loša kvaliteta
English: • fever, general feeling of being unwell
Croatian: • vrućica, opće loše osjećanje
English: High density polyethylene (HDPE) bottle with a child-resistant closure (HDPE) with foil induction seal
Croatian: Boca od polietilena visoke gustoće (HDPE) sa sigurnosnim zatvaračem (HDPE) za djecu i zalijepljenom