FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients with HIV-1 harbouring mutations
Croatian: Bolesnici s mutacijama virusa HIV-1
English: The mechanism of tumour formation and the potential relevance for humans are not known.
Croatian: Nije poznat mehanizam formiranja tumora niti potencijalan značaj za čovjeka.
English: There is insufficient information on the effects of efavirenz, emtricitabine and tenofovir in newborns/infants.
Croatian: Nema dovoljno podataka o učincima efavirenza, emtricitabina i tenofovira u novorođenčadi/dojenčadi.
English: Since fluoxetine shares a similar metabolic profile with paroxetine, i.e. a strong CYP2D6 inhibitory effect, a similar lack of interaction would be expected for fluoxetine.
Croatian: Budući da fluoksetin ima metabolitički profil sličan paroksetinu, tj. snažan učinak inhibicije CYP2D6, može se očekivati izostanak interakcije.
English: Atripla is not recommended in this population (see section 4.2).
Croatian: Ne preporučuje se primjena Atriple u ovoj populaciji (vidjeti dio 4.2).
English: Carcinogenicity studies showed an increased incidence of hepatic and pulmonary tumours in female mice, but not in male mice.
Croatian: Ispitivanja kancerogenosti pokazala su veću incidencija tumora na jetri i plućima u ženskih miševa, ali ne i u muških miševa.
English: If Atripla is stopped, speak to your doctor before you restart taking Atripla tablets.
Croatian: Ako ste prestali s uzimanjem Atriple, razgovarajte s liječnikom prije nego počnete ponovno uzimati tablete Atriple.
English: Emtricitabine (n=45)
Croatian: emtricitabin (n=45)
English: - Hormonal contraceptive, such as birth control pills, an injected contraceptive (for example, Depo-Provera), or a contraceptive implant (for example, Implanon): You must also use a reliable barrier method of contraception (see Pregnancy and breast-feeding).
Croatian: - Hormonski kontraceptivi, kao što su tablete za spriječavanje trudnoće, kontraceptivi koji se primjenjuju injiciranjem (na primjer, Depo-Provera), ili kontracepcijski implantati (na primjer, Implanon): Morate koristiti i pouzdanu mehaničku metodu kontracepcije (pogledajte Trudnoća i dojenje).
English: Emtricitabine is rapidly absorbed with peak plasma concentrations occurring at 1 to 2 hours post-dose.
Croatian: Emtricitabin se brzo apsorbirao, uz najveće koncentracije plazme 1 do 2 sata nakon uzimanja doze.
English: If you stop taking Atripla Don't stop taking Atripla without talking to your doctor.
Croatian: Nemojte prestati s uzimanjem Atriple bez razgovora sa svojim liječnikom.
English: Two additional cases (1 prospective and 1 retrospective) including events consistent with neural tube defects have been reported with the fixed-dose combination tablet containing efavirenz, emtricitabine, and tenofovir disoproxil.
Croatian: Prijavljena su dva dodatna slučaja (1 prospektivni i 1 retrospektivni) koja su uključivala događaje koji upućuju na oštećenja neuralne cijevi s primjenom tableta s fiksnom kombinacijom efavirenza, emtricitabina i tenofovir dizoproksila.
English: The clinical effect of this dose adjustment has not been adequately evaluated.
Croatian: Klinički učinci tog usklađivanja doze nisu adekvatno analizirani.
English: Atripla should not be used during pregnancy unless the clinical condition of the woman requires treatment with efavirenz/emtricitabine/tenofovir disoproxil.
Croatian: Atripla se ne smije primjenjivati tijekom trudnoće osim u slučaju da kliničko stanje žene zahtijeva liječenje efavirenzom/emtricitabinom/tenofovirdizoproksilom.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jirovecii pneumonia.
Croatian: Relevantni primjeri su citomegalovirusni retinitis, generalizirane i/ili žarišne mikobakterijske infekcije te upala pluća uzrokovana s Pneumocystis jirovecii.
English: If you think that you may have any of these serious side effects, talk to your doctor.
Croatian: Mislite li da imate bilo koju od ovih ozbiljnih nuspojava, obratite se svojem liječniku.
English: In HIV infected patients, peak efavirenz plasma concentrations were attained by 5 hours and steady-state concentrations reached in 6 to 7 days.
Croatian: U bolesnika inficiranih HIV-om najviše koncentracije efavirenza u plazmi postignute su za 5 sati, a koncentracija u stanju dinamičke ravnoteže za 6 do 7 dana.
English: Data on the clinical translation of the decrease in pharmacokinetic exposure are not available.
Croatian: Podaci o kliničkim učincima smanjenja farmakokinetičke izloženosti nisu dostupni.
English: • breakdown of muscle, muscle pain or weakness
Croatian: • propadanje mišića, bolovi u mišićima ili slabost mišića
English: After oral administration, tenofovir is widely distributed throughout the body.
Croatian: Nakon peroralne primjene, tenofovir je bio široko distribuiran cijelim tijelom.
English: If you could get pregnant while receiving Atripla, you need to use a reliable form of barrier contraception (for example, a condom) with other methods of contraception including oral (pill) or other hormonal contraceptives (for example, implants, injection).
Croatian: Ako postoji mogućnost da zatrudnite tijekom uzimanja Atriple, trebate koristiti pouzdanu mehaničku metodu kontracepcije (primjerice, kondom) u kombinaciji s drugim metodama kontracepcije, uključujući tablete (oralna kontracepcija) i druge oblike hormonske kontracepcije (na primjer, implantati, injekcije).
English: This medicinal product contains 23.6 mg sodium per dose, equivalent to 1.2% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Croatian: Ovaj lijek sadrži 23,6 mg natrija po dozi, što odgovara 1,2% maksimalnog dnevnog unosa od 2 g natrija prema preporukama SZO-a za odraslu osobu.
English: Compared to fasted administration, dosing of tenofovir disoproxil and emtricitabine in combination with either a high fat meal or a light meal increased the mean AUC of tenofovir by 43.6% and 40.5%, and Cmax by 16% and 13.5%, respectively without affecting emtricitabine exposures.
Croatian: U usporedbi s davanjem natašte, doziranje tenofovirdizoproksila i emtricitabina u kombinaciji s obrokom s velikom količinom masnoće ili laganim obrokom povećalo je srednju vrijednost AUC-a tenofovira za 43,6% odnosno 40,5% i vrijednost Cmax tenofovira za 16% odnosno 13,5%, bez utjecaja na izloženost emtricitabinu.
English: If Atripla is stopped your doctor may recommend that you resume hepatitis B treatment.
Croatian: Ako prestajete s uzimanjem Atriple, Vaš će liječnik možda preporučiti nastavak liječenja hepatitisa B.
English: In general, emtricitabine pharmacokinetics in HBV infected patients were similar to those in healthy subjects and in HIV infected patients.
Croatian: Općenito je farmakokinetika emtricitabina u osoba inficiranih virusom HBV-a bila slična farmakokinetici u zdravih ispitanika i u HIV-om zaraženih bolesnika.
English: The mean plasma to blood concentration ratio was approximately 1.0 and the mean semen to plasma concentration ratio was approximately 4.0.
Croatian: Srednja vrijednost omjera koncentracija u plazmi naspram krvi bila je približno 1,0 a srednja vrijednost omjera koncentracija u spermi naspram plazme bila je približno 4,0.
English: Table 5: Maintenance of pure virologic response (Kaplan Meier % (Standard Error) [95%CI]) at week 48 for treatment-experienced patients with baseline HIV-1 RNA < 75 copies/ml who had therapy switched to Atripla according to the type of prior antiretroviral regimen (Kaiser Permanente patient database)
Croatian: Tablica 5: Održavanje čistog virološkog odgovora (% po Kaplan-Meierovoj metodi (standardna pogreška) [95%CI]) u 48. tjednu za prethodno liječene bolesnike s početnom raznom HIV-1 RNA < 75 kopija/ml koji su prešli na liječenje Atriplom u skladu s vrstom prethodnog antiretrovirusnog režima (baza podataka bolesnika Kaiser Permanente)
English: Atripla may make hormonal contraceptives less likely to work.
Croatian: Atripla može smanjiti učinkovitost hormonskih kontraceptiva.
English: Patients co-infected with HIV and HBV who discontinue Atripla must be closely monitored with both clinical and laboratory follow-up for at least four months after stopping treatment with Atripla.
Croatian: Bolesnike istodobno inficirane HIV-om i HBV-om koji prekinu liječenje Atriplom treba pažljivo klinički i laboratorijski pratiti najmanje četiri mjeseca nakon prekida liječenja Atriplom.
English: Tenofovir disoproxil and emtricitabine, two of the active substances in Atripla, show some activity against hepatitis B virus although emtricitabine is not approved for the treatment of hepatitis B infection.
Croatian: Tenofovirdizoproksil i emtricitabin, dvije od djelatnih tvari koje sadržava Atripla, pokazuju određenu aktivnost protiv virusa hepatitisa B, iako emtricitabin nije odobren za liječenje infekcije hepatitisa B.
English: Patients who are receiving concomitant anticonvulsant medicinal products primarily metabolised by the liver, such as phenytoin, carbamazepine and phenobarbital, may require periodic monitoring of plasma levels.
Croatian: U bolesnika koji istodobno primaju antikonvulzivne lijekove koji se primarno metaboliziraju u jetri, poput fenitoina, karbamazepina i fenobarbitala, može postojati potreba za periodičkom kontrolom razine ovih lijekova u plazmi.
English: Therefore Atripla should not be used during breast-feeding.
Croatian: Stoga se Atripla ne smije primjenjivati tijekom dojenja.
English: elevated serum AST and/or elevated serum ALT, hyperbilirubinaemia increased transaminases
Croatian: povišen AST u serumu i/ili povišen ALT u serumu, hiperbilirubinemija povišene transaminaze
English: When your supply of Atripla starts to run low, get more from your doctor or pharmacist.
Croatian: Kada se Vaša zaliha Atriple približi kraju, nabavite novu količinu od liječnika ili ljekarnika.
English: Adults The recommended dose of Atripla is one tablet taken orally once daily.
Croatian: Preporučena doza Atriple je jedna tableta dnevno primijenjena peroralno.
English: Emtricitabine and tenofovir individually and in combination have shown activity against HBV in pharmacodynamic studies (see section 5.1).
Croatian: Emtricitabin i tenofovir su u farmakodinamičkim ispitivanjima pojedinačno i u kombinaciji pokazali aktivnost protiv HBV-a (vidjeti dio 5.1).
English: Osteonecrosis: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Croatian: Osteonekroza: Zabilježeni su slučajevi osteonekroze, osobito u bolesnika s općepoznatim čimbenicima rizika, uznapredovalom HIV bolešću ili dugotrajnom izloženošću CART-u.
English: - Medicines used to treat bacterial infections, including tuberculosis and AIDS-related mycobacterium avium complex: Clarithromycin, rifabutin, rifampicin.
Croatian: - Lijekovi koji se koriste za liječenje bakterijskih infekcija, uključujući tuberkulozu i infekciju s Mycobacterium avium kompleksom koja je povezana s AIDS-om: klaritromicin, rifabutin, rifampicin.
English: High rates of virologic suppression were maintained by subjects from both initial treatment groups who then received Atripla in the open-label extended phase of the study.
Croatian: Visoke stope virološke supresije bile su održane u bolesnika u obje skupine na početku liječenja koje su potom primale Atriplu u otvorenoj, proširenoj fazi ispitivanja.
English: The effect of efavirenz on the QTc interval was evaluated in an open-label, positive and placebo controlled, fixed single sequence 3-period, 3-treatment crossover QT study in 58 healthy subjects enriched for CYP2B6 polymorphisms.
Croatian: Učinak efavirenza na QTc interval procijenjen je u otvorenom, aktivnim komparatorom i placebom kontroliranom, ukriženom ispitivanju QT-a s jednim fiksnim slijedom 3 razdoblja odnosno 3 liječenja u 58 zdravih ispitanika s izraženim polimorfizmom CYP2B6.
English: Limited clinical experience in patients co-infected with HIV and HBV suggests that treatment with emtricitabine or tenofovir disoproxil in antiretroviral combination therapy to control HIV infection also results in a reduction in HBV DNA (3 log10 reduction or 4 to 5 log10 reduction, respectively) (see section 4.4).
Croatian: Ograničeno kliničko iskustvo u bolesnika koji su istodobno inficirani HIV-om i HBV-om navodi na zaključak da liječenje s emtricitabinom ili tenofovirdiozproksilom u kombiniranoj antiretrovirusnoj terapiji, u cilju kontroliranja infekcije HIV-om također rezultira smanjenjem HBV DNK (smanjenje od 3 log10, odnosno smanjenje od 4 do 5 log10) (vidjeti dio 4.4).
English: Typically, such reactions have been observed within the first few weeks or months of initiation of CART.
Croatian: Takve su reakcije tipično zapažene unutar prvih nekoliko tjedana ili mjeseci po uvođenju kombinirane antiretrovirusne terapije.
English: Renal clearance has been estimated to be approximately 210 ml/min, which is in excess of the glomerular filtration rate.
Croatian: Procijenjeno je da je bubrežni klirens oko 210 ml/min, što prelazi brzinu glomerularne filtracije.
English: If Atripla is to be used in combination with darunavir/ritonavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used.
Croatian: Ako će se Atripla primjenjivati u kombinaciji s darunavirom/ritonavirom, treba primjenjivati režim darunavira/ritonavira od 600/100 mg dvaput na dan.
English: Your doctor may consider giving you an alternative medicine or changing the dose of the protease inhibitors.
Croatian: Vaš će liječnik možda razmotriti uvođenje zamjenskog lijeka ili mijenjanje doze inhibitora proteaze.
English: The oral bioavailability of tenofovir from tenofovir disoproxil in fasted patients was approximately 25%.
Croatian: Peroralna bioraspoloživost tenofovira iz tenofovirdizoproksila u bolesnika natašte bila je približno 25%.
English: Atripla contains sodium
Croatian: Atripla sadrži natrij
English: They may occur more frequently when Atripla is taken concomitantly with meals possibly due to increased efavirenz plasma levels (see section 5.2).
Croatian: Mogu se pojaviti i češće ako se Atripla uzima istodobno s obrocima, moguće zbog povećanih razina efavirenza u plazmi (vidjeti dio 5.2).
English: The systemic clearance of emtricitabine averaged 307 ml/min.
Croatian: Sistemski klirens emtricitabina u prosjeku je iznosio 307 ml/min.
English: In vitro studies have determined that neither tenofovir disoproxil nor tenofovir are substrates for the CYP enzymes.
Croatian: In vitro ispitivanja pokazala su da ni tenofovirdizoproksil niti tenofovir nisu supstrati za CYP enzime.
English: There is no clinical experience with Atripla in patients who are experiencing virological failure in a first-line antiretroviral treatment regimen or in combination with other antiretroviral agents.
Croatian: Nema kliničkih iskustava s Atriplom u bolesnika s virološkim neuspjehom u primarnom režimu antiretrovirusnog liječenja ili u kombinaciji s drugim antiretrovirusnim lijekovima.
English: Musculoskeletal and connective tissue disorders: Very common elevated creatine kinase
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva: Vrlo često povišena kreatin kinaza
English: These patients should be carefully monitored for rises in viral load and, since the safety profile of efavirenz differs from that of protease inhibitors, for adverse reactions.
Croatian: Te bolesnike nužno je pomno pratiti radi mogućnosti povećanja virusnog opterećenja te, budući da se sigurnosni profil efavirenza razlikuje od profila inhibitora proteaze, potrebno ih je pratiti radi moguće pojave nuspojava.
English: Since Atripla is a combination product and the dosing interval of the individual components cannot be altered, treatment with Atripla must be interrupted in patients with confirmed creatinine clearance < 50 ml/min or decreases in serum phosphate to < 1.0 mg/dl (0.32 mmol/l).
Croatian: Budući da je Atripla kombinirani lijek i intervali doziranja pojedinačnih komponenti ne mogu se mijenjati, liječenje Atriplom mora se prekinuti u bolesnika u kojih je potvrđen klirens kreatinina < 50 ml/min ili u kojih je razina fosfata u serumu snižena na < 1,0 mg/dl (0,32 mmol/l).
English: Bone toxicity was diagnosed as osteomalacia (monkeys) and reduced bone mineral density (BMD) (rats and dogs).
Croatian: Toksičnost za kosti dijagnosticirana je kao osteomalacija (kod majmuna) i snižena mineralna gustoća kostiju (kod štakora i pasa).
English: Co-administration with drugs that are known to prolong the QTc interval (proarrhythmic).
Croatian: Istodobna primjena s lijekovima za koje je poznato da produljuju QTc interval (proaritmici).
English: Your doctor will check your cholesterol levels and will consider changing the dose of your statin, if needed.
Croatian: Liječnik će provjeravati razine kolesterola u Vašoj krvi i prema potrebi razmotriti mijenjanje doze statina.
English: Competition for cytochrome P450 (CYP) 3A4 by efavirenz could result in inhibition of metabolism and create the potential for serious and/or life-threatening adverse reactions (for example, cardiac arrhythmias, prolonged sedation or respiratory depression) (see section 4.5).
Croatian: Kompeticija efavirenza za citokrom P450 (CYP) 3A4 može dovesti do inhibicije metabolizma i stvoriti mogućnost ozbiljnih i/ili po život opasnih nuspojava (na primjer, srčanih aritmija, produljene sedacije ili respiratorne depresije) (vidjeti dio 4.5).
English: As of July 2013, the Antiretroviral Pregnancy Registry (APR) has received prospective reports of 904 pregnancies with first trimester exposure to efavirenz-containing regimens, resulting in 766 live births.
Croatian: Zaključno sa srpnjem 2013. godine u Registar trudnica koje primaju antiretrovirotik (Antiretroviral Pregnancy Registry, APR) zaprimljena su prospektivna izvješća o praćenju ishoda 904 trudnoće u kojima su trudnice bile izložene režimu liječenja s efavirenzom tijekom prvog tromjesečja trudnoće, a rezultirale su rođenjem 766 žive djece.
English: Clinically significant interactions are not expected as simeprevir and emtricitabine are eliminated via different pathways.
Croatian: Ne očekuju se klinički značajne interakcije jer se simeprevir i emtricitabin eliminiraju različitim putevima.
English: 1 Other efavirenz resistance mutations included A98G (n=1), K103E (n=1), V179D (n=1), and M230L (n=1).
Croatian: 1 Druge mutacije za rezistenciju na efavirenz uključivale su A98G (n=1), K103E (n=1), V179D (n=1) i M230L
English: K103N was the most frequently observed RT substitution in viral isolates from patients who experienced rebound in viral load during clinical studies of efavirenz.
Croatian: K103N je bila najčešće opažena RT supstitucija pri virusnim izolatima dobivenim od bolesnika kod kojih je tijekom kliničkih ispitivanja efavirenza došlo do povrata (rebound) virusnog opterećenja.
English: Refer to the Summary of Product Characteristics for the medicinal product containing maraviroc.
Croatian: Pogledajte sažetak opisa svojstava lijeka za lijek koji sadržava maravirok.
English: Please refer to the Summary of Product Characteristics for these medicinal products.
Croatian: Molimo pročitajte Sažetke opisa svojstava lijeka tih lijekova.
English: - if you have a heart condition, such as an abnormal electrical signal called prolongation of the QT interval that puts you at high risk for severe heart rhythm problems (Torsade de Pointes).
Croatian: - ako imate bolest srca, kao što je abnormalan električni signal koji se naziva produljenje QT intervala, zbog čega ste izloženi visokom riziku od teških problema sa srčanim ritmom
English: Prior Atripla components (N=299)
Croatian: Prethodno liječenje komponentama Atriple (N=299)
English: - bone problems.
Croatian: - tegobe s kostima.
English: Efavirenz significantly decreases voriconazole plasma concentrations while voriconazole also significantly increases efavirenz plasma concentrations.
Croatian: Efavirenz značajno smanjuje koncentraciju vorikonazola u plazmi, dok vorikonazol značajno povećava koncentraciju efavirenza u plazmi.
English: Efavirenz is an in vivo inducer of CYP3A4, CYP2B6 and UGT1A1.
Croatian: Efavirenz djeluje kao in vivo induktor CYP3A4, CYP2B6 i UGT1A1.
English: Co-administration of higher doses of either efavirenz or carbamazepine has not been studied.
Croatian: Istodobna primjena viših doza efavirenza ili karbamazepina nije ispitana.
English: • increased cholesterol in the blood
Croatian: • povećan kolesterol u krvi
English: Efavirenz has been shown to induce CYP3A4 and CYP2B6, resulting in the induction of its own metabolism, which may be clinically relevant in some patients.
Croatian: Pokazalo se da efavirenz inducira CYP3A4 i CYP2B6, što dovodi do indukcije njegovog vlastitog metabolizma, što može biti klinički važno u nekih bolesnika.
English: Phenytoin, Phenobarbital, and other anticonvulsants that are substrates of CYP isozymes
Croatian: fenitoin, fenobarbital i drugi antikonvulzivi koji su supstrati CYP izozima
English: 2D barcode carrying the unique identifier included.
Croatian: 17. JEDINSTVENI IDENTIFIKATOR - 2D BARKOD Sadrži 2D barkod s jedinstvenim identifikatorom. [samo vanjsko pakiranje]
English: Insufficient numbers of patients over 65 years of age have been studied.
Croatian: Provedena su ispitivanja na premalom broju bolesnika starijih od 65 godina.
English: Table 4: 48-week efficacy data from study AI266073 in which Atripla was administered to virologically suppressed patients on combination antiretroviral therapy
Croatian: Tablica 4: Podaci o djelotvornosti za 48 tjedana iz ispitivanja AI266073 u kojem je Atripla davana bolesnicima s virološkom supresijom koji su primali kombiniranu antiretrovirusnu terapiju
English: Malformations have been observed in foetuses from efavirenz-treated monkeys (see section 5.3).
Croatian: Malformacije su uočene u plodova majmuna koji su tretirani efavirenzom (vidjeti dio 5.3).
English: No data are available to support the combination of Atripla and other antiretroviral agents.
Croatian: Nema dostupnih podataka koji bi poduprli primjenu kombinacije Atriple i drugih antiretrovirusnih tvari.
English: The rash associated with the efavirenz component usually resolves with continued therapy.
Croatian: Osip povezan s komponentom efavirenzom obično nestaje u nastavku terapije.
English: Studies in humans and in vitro studies using human liver microsomes have demonstrated that efavirenz is principally metabolised by the CYP system to hydroxylated metabolites with subsequent glucuronidation of these hydroxylated metabolites.
Croatian: Biotransformacija ispitivanja na ljudima i in vitro ispitivanja uz korištenje ljudskih jetrenih mikrosoma pokazala su da se efavirenz pretežno metabolizira CYP sustavom, i to u hidroksilirane metabolite s naknadnom glukoronizacijom tih hidroksiliranih metabolita.
English: Limited clinical experience suggests that emtricitabine and tenofovir disoproxil have an anti-HBV activity when used in antiretroviral combination therapy to control HIV infection.
Croatian: Ograničeno kliničko iskustvo navodi na zaključak da emtricitabin i tenofovirdizoproksil posjeduju anti-HBV aktivnost kada se upotrebljavaju u antiretrovirusnoj kombiniranoj terapiji za kontrolu infekcije HIV-om.
English: Decreases in bone mineral density of spine and changes in bone biomarkers from baseline were significantly greater in the tenofovir disoproxil treatment group at 144 weeks.
Croatian: Smanjenje mineralne gustoće kosti kralježnice i promjene koštanih biomarkera od početne vrijednosti bile su pri 144 tjedna značajno veće u skupini liječenoj tenofovirdizoproksilom.
English: Test: single fixed-dose combination tablet taken under fasted conditions.
Croatian: Test: jedna tableta s fiksnom kombinacijom doza uzeta natašte.
English: Pharmacokinetic studies have not been performed with Atripla in infants and children under 18 years of age (see section 4.2).
Croatian: Pedijatrijska populacija Nisu provedena farmakokinetička ispitivanja Atriple na dojenčadi i djeci mlađoj od 18 godina (vidjeti dio 4.2).
English: Methadone:
Croatian: metadon:
English: Limited data suggest that females may have higher exposure to efavirenz but they do not appear to be less tolerant of efavirenz.
Croatian: Ograničeni podaci ukazuju da je u žena možda prisutna veća izloženost efavirenzu, ali ne čini se da u žena postoji manja tolerancija na efavirenz.