FrancophonIA/ELRC3.0 huggingface dataset:
English: Estimated frequency based on all clinical trial data.
Croatian: Učestalost procijenjena na temelju svih podataka iz kliničkih ispitivanja.
English: Cases of convulsion and cases of tinnitus have also been reported after treatment discontinuation.
Croatian: Slučajevi konvulzija i tinitusa prijavljeni su i nakon prekida liječenja.
English: The use of duloxetine has been associated with the development of akathisia, characterised by a subjectively unpleasant or distressing restlessness and need to move often accompanied by an inability to sit or stand still.
Croatian: Primjena duloksetina povezana je s razvojem akatizije, koju karakterizira subjektivno neugodan ili tjeskoban nemir i potreba za kretanjem, često praćena nesposobnošću mirnog sjedenja ili stajanja.
English: Duloxetine has a large volume of distribution and forced diuresis, haemoperfusion, and exchange perfusion are unlikely to be beneficial.
Croatian: Duloksetin ima velik volumen distribucije te forsirana diureza, hemoperfuzija i izmjena perfuzijom vjerojatno ne bi koristile.
English: Duloxetine Mylan is available in 2 strengths: 30 mg and 60 mg.
Croatian: Duloxetine Mylan dostupan je u 2 jačine: 30 mg i 60 mg.
English: You should inform your doctor if any of the symptoms listed above develop or worsen when patients under 18 are taking Duloxetine Mylan.
Croatian: Morate obavijestiti liječnika ako se pojavi ili pogorša bilo koji od gore navedenih simptoma kad bolesnik mlađi od 18 godina uzima lijek
English: Hyponatraemia may be due to a syndrome of inappropriate anti-diuretic hormone secretion (SIADH).
Croatian: Hiponatrijemija može biti uzrokovana sindromom neprikladnog izlučivanja antidiuretskog hormona (engl. syndrome of inappropriate antidiuretic hormone secretion, SIADH).
English: The co-administration of duloxetine (40 mg twice daily) increases steady state AUC of tolterodine (2 mg twice daily) by 71%, but does not affect the pharmacokinetics of its active 5-hydroxyl metabolite and no dosage adjustment is recommended.
Croatian: Istodobna primjena duloksetina (40 mg dvaput dnevno) povećava AUC tolterodina (2 mg dvaput dnevno) u stanju dinamičke ravnoteže za 71%, ali ne utječe na farmakokinetiku njegova aktivnog 5-hidroksil metabolita pa se prilagodba doze ne preporučuje.
English: How to store Duloxetine Mylan Contents of the pack and other information
Croatian: Kako čuvati lijek Duloxetine Mylan Sadržaj pakiranja i druge informacije
English: Hepatic impairment: Moderate liver disease (Child Pugh Class B) affected the pharmacokinetics of duloxetine.
Croatian: Oštećenje jetrene funkcije: Umjereno teška bolest jetre (Child Pugh stadij B) utjecala je na farmakokinetiku duloksetina.
English: Medicines like Duloxetine Mylan (so called SSRIs/SNRIs) may cause symptoms of sexual dysfunction (see section 4).
Croatian: Lijekovi poput Duloxentine Mylan (takozvani SSRI-ovi/SNRI-ovi) mogu uzrokovati simptome poremećaja seksualne funkcije (vidjeti dio 4).
English: What Duloxetine Mylan is and what it is used for What you need to know before you take Duloxetine Mylan How to take Duloxetine Mylan Possible side effects
Croatian: Što je Duloxetine Mylan i za što se koristi Što morate znati prije nego počnete uzimati lijek Duloxetine Mylan Kako uzimati lijek Duloxetine Mylan Moguće nuspojave
English: To help you remember to take Duloxetine Mylan, you may find it easier to take it at the same times every day.
Croatian: Možda ćete se lakše sjetiti da morate uzeti lijek Duloxetine Mylan ako ga svakog dana budete uzimali u isto vrijeme.
English: The randomised, double-blind, placebo-controlled, parallel study of duloxetine was conducted in 184 adolescents aged 13 to 18 years (mean age 15.53 years) with JPFS.
Croatian: To randomizirano, dvostruko slijepo, placebom kontrolirano ispitivanje duloksetina s paralelnim skupinama provedeno je u 184 adolescenta s JPFS-om u dobi od 13 do 18 godina (srednja vrijednost dobi: 15,53 godine).
English: • fainting, dizziness, lightheadedness or fainting on standing up, cold fingers and/or toes
Croatian: • nesvjestica, omaglica, ošamućenost ili nesvjestica pri ustajanju, hladni prsti na rukama i/ili nogama
English: Female mice receiving duloxetine for 2 years had an increased incidence of hepatocellular adenomas and carcinomas at the high dose only (144 mg/kg/day), but these were considered to be secondary to hepatic microsomal enzyme induction.
Croatian: U ženki miševa koje su primale duloksetin tijekom 2 godine uočena je povećana incidencija hepatocelularnih adenoma i karcinoma, ali samo kod visokih doza (144 mg/kg/dan); no to se smatra posljedicom indukcije mikrosomalnih jetrenih enzima.
English: The study included a 10 week placebo-controlled acute phase, followed by an 18 week extension treatment period.
Croatian: Ispitivanje se sastojalo od 10-tjedne akutne faze kontrolirane placebom, iza koje je slijedilo 18-tjedno razdoblje produžetka liječenja.
English: Both cytochromes P450-2D6 and 1A2 catalyse the formation of the two major metabolites glucuronide conjugate of 4-hydroxy duloxetine and sulfate conjugate of 5-hydroxy 6-methoxy duloxetine.
Croatian: Citokromi P450-2D6 i 1A2 kataliziraju stvaranje dvaju glavnih metabolita, glukuronidnog konjugata 4-hidroksi duloksetina i sulfatnog konjugata 5-hidroksi 6-metoksi duloksetina.
English: Duloxetine Mylan may cause a sensation of restlessness or an inability to sit or stand still.
Croatian: Duloxetine Mylan može izazvati osjećaj nemira ili nemogućnost mirnog sjedenja ili stajanja.
English: • headache, feeling sleepy
Croatian: • glavobolja, pospanost
English: The usual starting dose of Duloxetine Mylan is 30 mg once a day after which most patients will receive 60 mg once a day, but your doctor will prescribe the dose that is right for you.
Croatian: Uobičajena početna doza lijeka Duloxetine Mylan je 30 mg jednom na dan, nakon čega će većina bolesnika primati 60 mg jednom na dan, no liječnik će propisati dozu koja Vama najbolje odgovara.
English: • Make sure your midwife and/or doctor knows you are on Duloxetine Mylan.
Croatian: • Budite sigurni da primalja i/ili liječnik znaju da uzimate lijek Duloxetine Mylan.
English: Monoamine oxidase inhibitors (MAOIs): Due to the risk of serotonin syndrome, duloxetine should not be used in combination with non-selective irreversible monoamine oxidase inhibitors (MAOIs), or within at least 14 days of discontinuing treatment with an MAOI.
Croatian: Inhibitori monoaminooksidaze (MAOI): Zbog rizika od serotoninskog sindroma duloksetin se ne smije uzimati u kombinaciji s neselektivnim ireverzibilnim inhibitorima monoaminooksidaze (MAOI) niti najmanje 14 dana nakon prekida liječenja inhibitorima MAO.
English: Epidemiological data have suggested that the use of SSRIs in pregnancy, particularly in late pregnancy, may increase the risk of persistent pulmonary hypertension in the newborn (PPHN).
Croatian: Epidemiološki podaci ukazuju na to da primjena selektivnih inhibitora ponovne pohrane serotonina (SSRI) u trudnoći, osobito u visokom stupnju trudnoće, može povećati rizik od perzistentne plućne hipertenzije u novorođenčadi (PPHN).
English: However, data on elderly patients exposed to the maximum dose (120 mg per day) are limited and thus, caution is recommended when treating this population.
Croatian: Međutim, podaci o starijim bolesnicima izloženima maksimalnoj dozi (120 mg na dan) su ograničeni i stoga se preporučuje oprez kod liječenja ove populacije.
English: Talk with your doctor about how long you should keep taking Duloxetine Mylan.
Croatian: Razgovarajte s liječnikom o tome koliko dugo trebate uzimati lijek Duloxetine Mylan.
English: Duloxetine Mylan increases the levels of serotonin and noradrenaline in the nervous system.
Croatian: Duloxetine Mylan povećava razinu serotonina i noradrenalina u živčanom sustavu.
English: Do not use this medicine after the expiry date which is stated on the carton.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake „EXP”.
English: Duloxetine may increase the risk of postpartum haemorrhage (see section 4.6).
Croatian: Duloksetin može povećati rizik od poslijeporođajnog krvarenja (vidjeti dio 4.6).
English: The European Medicines Agency has waived the obligation to submit the results of studies with duloxetine in all subsets of the paediatric population in the treatment of major depressive disorder, diabetic neuropathic pain and generalised anxiety disorder.
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja duloksetina u svim podskupinama pedijatrijske populacije u liječenju velikog depresivnog poremećaja, boli kod dijabetičke neuropatije i generaliziranog anksioznog poremećaja.
English: Duloxetine Mylan should be used with caution in patients with a history of mania or a diagnosis of bipolar disorder, and/or seizures.
Croatian: Duloxetine Mylan se mora s oprezom davati bolesnicima s manijom u anamnezi ili s dijagnozom bipolarnog poremećaja i/ili napadaja.
English: Table 1 gives the adverse reactions observed from spontaneous reporting and in placebo-controlled clinical trials.
Croatian: Tablici 1 prikazane su nuspojave prikupljene iz spontanih prijava i u placebom kontroliranim kliničkim ispitivanjima.
English: In patients responding to duloxetine, and with a history of repeated episodes of major depression, further long-term treatment at a dose of 60 to 120 mg/day could be considered.
Croatian: U bolesnika koji su reagirali na duloksetin, a u anamnezi imaju ponavljajuće epizode velike depresije, može se razmotriti daljnje dugotrajno liječenje dozom od 60-120 mg/dan.
English: When stopping treatment with Duloxetine Mylan the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions (see sections 4.4 and 4.8).
Croatian: Kada se liječenje lijekom Duloxetine Mylan prekida, doza se mora smanjivati postupno tijekom razdoblja od najmanje jednog do dva tjedna kako bi se smanjio rizik od pojave simptoma ustezanja (vidjeti dijelove 4.4 i 4.8).
English: The usual dose of Duloxetine Mylan is 60 mg once a day, but your doctor will prescribe the dose that is right for you.
Croatian: Uobičajena doza lijeka Duloxetine Mylan je 60 mg jednom na dan, no liječnik će Vam propisati dozu koja Vama najbolje odgovara.
English: • coughing, wheezing and shortness of breath which may be accompanied by a high temperature
Croatian: • kašalj, piskanje pri disanju i nedostatak zraka mogu biti popraćeni visokom temperaturom
English: In studies of up to 9 months an overall mean decrease of 1% in height percentile (decrease of 2% in children (7-11 years) and increase of 0.3% in adolescents (12-17 years)) was observed in duloxetinetreated paediatric patients (see section 4.4).
Croatian: U ispitivanjima u trajanju do 9 mjeseci, u pedijatrijskih bolesnika liječenih duloksetinom primijećena je ukupna srednja vrijednost smanjenja percentila visine za 1% (smanjenje za 2% u djece (711 godina) i porast od 0,3% u adolescenata (12-17 godina)) (vidjeti dio 4.4).
English: For depression and diabetic neuropathic pain:
Croatian: Za depresiju i bol kod dijabetičke neuropatije:
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke šećere, savjetujte se s njime prije uzimanja ovog lijeka.
English: 30 mg capsules
Croatian: 30 mg kapsule
English: Care should be taken if you drink alcohol while you are being treated with Duloxetine Mylan.
Croatian: Budite oprezni ako pijete alkohol dok se liječite lijekom Duloxetine Mylan.
English: Your doctor should decide whether you can take Duloxetine Mylan with other medicines.
Croatian: Liječnik mora donijeti odluku o tome smijete li uzimati lijek Duloxetine Mylan s drugim lijekovima.
English: Duloxetine did not show efficacy in reducing pain as measured by primary outcome measure of Brief Pain Inventory (BPI) average pain score endpoint: least squares (LS) mean change from baseline in BPI average pain score at 13 weeks was0.97 in the placebo group, compared with -1.62 in the duloxetine 30/60 mg group (p = 0.052).
Croatian: Duloksetin nije pokazao djelotvornost u ublažavanju boli, što se mjerilo prosječnim rezultatom za bol u kratkom upitniku o boli (engl. brief pain inventory, BPI), koji je bio primarna mjera ishoda: srednja vrijednost promjene prosječnog BPI rezultata za bol od početka ispitivanja do 13. tjedna, izračunata metodom najmanjih kvadrata, iznosila je -0,97 u skupini koja je primala placebo u odnosu na -1,62 u skupini liječenoj duloksetinom u dozi od 30/60 mg (p = 0,052).
English: As the safety of duloxetine in infants is not known, the use of Duloxetine Mylan while breast-feeding is not recommended.
Croatian: Budući da sigurnost primjene duloksetina u dojenčadi nije poznata, ne preporučuje se primjena lijeka Duloxetine Mylan u dojilja.
English: Duloxetine Mylan should normally not be used for children and adolescents under 18 years.
Croatian: Duloxetine Mylan se u načelu ne smije primjenjivati u djece i adolescenata mlađih od 18 godina.
English: The use of more than one of these products concomitantly should be avoided.
Croatian: Mora se izbjegavati istodobna primjena više od jednog takvog lijeka.
English: In both studies, duloxetine 60 mg once daily and 60 mg twice daily significantly reduced pain compared with placebo.
Croatian: U oba je ispitivanja duloksetin u dozi od 60 mg jednom dnevno i 60 mg dva puta dnevno značajno umanjio bol u usporedbi s placebom.
English: Also, the long-term safety effects concerning growth, maturation, and cognitive and behavioural development of Duloxetine Mylan in this age group have not yet been demonstrated.
Croatian: Nadalje, dugoročni sigurnosni učinci lijeka Duloxetine Mylan na rast, sazrijevanje te intelektualni razvoj i razvoj ponašanja nisu još dokazani u ovoj dobnoj skupini.
English: You should use Duloxetine Mylan only after discussing the potential benefits and any potential risks to your unborn child with your doctor.
Croatian: Smijete uzimati lijek Duloxetine Mylan tek nakon što razgovarate s liječnikom o mogućim koristima i rizicima za nerođeno dijete.
English: Stevens-Johnson Syndrome Angio-neurotic oedema
Croatian: Stevens-Johnsonov sindrom angioneurotski edem kutani vaskulitis
English: Other medicines and Duloxetine Mylan
Croatian: Drugi lijekovi i Duloxetine Mylan
English: 60 mg capsules
Croatian: 60 mg kapsule
English: Selective serotonin reuptake inhibitors (SSRIs)/serotonin norepinephrine reuptake inhibitors (SNRIs) may cause symptoms of sexual dysfunction (see section 4.8).
Croatian: Selektivni inhibitori ponovne pohrane serotonina (SSRI-ovi) / inhibitori ponovne pohrane serotonina i noradrenalina (SNRI-ovi) mogu uzrokovati simptome poremećaja seksualne funkcije (vidjeti dio 4.8).
English: Duloxetine Mylan is used in adults to treat:
Croatian: Duloxetine Mylan se primjenjuje u odraslih za liječenje:
English: • sudden involuntary jerks or twitches of the muscles, sensation of restlessness or an inability to sit or stand still, feeling nervous, difficulty concentrating, changes in sense of taste, difficulty controlling movement e.g. lack of coordination or involuntary movements of the muscles, restless legs syndrome, poor sleep quality
Croatian: • iznenadni nevoljni trzaji ili grčevi mišića, osjećaj nemira ili nemogućnost mirnog sjedenja ili stajanja, nervoza, poteškoće s koncentracijom, promjene osjeta okusa, poteškoće pri kontroliranju pokreta npr. nedostatak koordinacije ili nevoljni pokreti mišića, sindrom nemirnih nogu, loša kvaliteta sna
English: The amount of duloxetine in breast milk is approximately 7 μg/day while on 40 mg twice daily dosing.
Croatian: Količina duloksetina u majčinom mlijeku iznosi približno 7 µg/dan ako majke uzimaju dozu od 40 mg dva puta dnevno.
English: Diabetic Peripheral Neuropathic Pain: The efficacy of duloxetine as a treatment for diabetic neuropathic pain was established in 2 randomised, 12-week, double-blind, placebo-controlled, fixed dose studies in adults (22 to 88 years) having diabetic neuropathic pain for at least 6 months.
Croatian: Bol kod dijabetičke periferne neuropatije: Djelotvornost dulokestina u liječenju boli kod dijabetičke neuropatije utvrđena je u dva randomizirana, 12-tjedna, dvostruko slijepa, placebom kontrolirana ispitivanja fiksnih doza u odraslih (u dobi od 22 do 88 godina) koji su imali bolnu dijabetičku neuropatiju najmanje 6 mjeseci.
English: Duloxetine normalised pain thresholds in several preclinical models of neuropathic and inflammatory pain and attenuated pain behaviour in a model of persistent pain.
Croatian: Duloksetin je normalizirao prag boli u nekoliko pretkliničkih modela neuropatske i upalne boli te je umanjio bolno ponašanje u modelu dugotrajne boli.
English: Duloxetine is a combined serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor.
Croatian: Duloksetin je kombinirani inhibitor ponovne pohrane serotonina (5-HT) i noradrenalina (NA).
English: During the 52-week placebo-controlled double blind treatment phase 14.4% of the duloxetine-treated patients and 33.1% of the placebo-treated patients experience a return of their depressive symptoms (p<0.001).
Croatian: Tijekom 52 tjedna placebom kontrolirane dvostruko slijepe faze liječenja u 14,4% bolesnika liječenih duloksetinom te u 33,1% bolesnika koji su primali placebo došlo je do povratka simptoma depresije (p<0,001).
English: The most commonly reported adverse reactions in patients treated with duloxetine were nausea, headache, dry mouth, somnolence, and dizziness.
Croatian: Najčešće prijavljene nuspojave u bolesnika liječenih duloksetinom bile su mučnina, glavobolja, suha usta, somnolencija i omaglica.
English: Capsule shell: Brilliant blue (E133), yellow iron oxide (E172) (60 mg only), titanium dioxide (E171), gelatin and edible gold ink (30 mg only) or edible white ink (60 mg only).
Croatian: Brilliant blue (E133), žuti željezov oksid (samo 60 mg), titanijev dioksid (E171), želatina i jestiva zlatna tinta (samo 30 mg) ili jestiva bijela tinta (samo 60 mg).
English: The antibiotic linezolid is a reversible non-selective MAOI and should not be given to patients treated with Duloxetine Mylan (see section 4.4).
Croatian: Antibiotik linezolid je reverzibilan neselektivan MAO inhibitor i ne smije se davati bolesnicima koji se liječe lijekom Duloxetine Mylan (vidjeti dio 4.4).
English: Based on the half-life of duloxetine, at least 5 days should be allowed after stopping Duloxetine Mylan before starting an MAOI (see section 4.3).
Croatian: S obzirom na poluvijek duloksetina, mora proći najmanje 5 dana nakon prestanka uzimanja lijeka Duloxetine Mylan prije započinjanja liječenja inhibitorom MAO (vidjeti dio 4.3).
English: In the extension phase of these studies, which lasted up to 52 weeks, there was an increase in HbA1c in both the duloxetine and routine care groups, but the mean increase was 0.3% greater in the duloxetine-treated group.
Croatian: U produžetku tih ispitivanja, koje je trajalo do 52 tjedna, HbA1c se povećao i u skupini liječenoj duloksetinom i u skupini bolesnika na standardnom liječenju, ali je srednja vrijednost porasta bila za 0,3% veća u skupini koja je primala duloksetin.
English: Taking a MAOI together with many prescription medicines, including Duloxetine Mylan, can cause serious or even life-threatening side effects.
Croatian: Uzimanje inhibitora MAO zajedno s mnogim lijekovima koji se izdaju na recept, uključujući lijek Duloxetine Mylan, može izazvati ozbiljne, čak i po život opasne nuspojave.
English: A total of 467 paediatric patients initially randomized to duloxetine in clinical trials, experienced a 0.1 kg mean decrease in weight at 10-weeks compared with a 0.9 kg mean increase in 353 placebo-treated patients.
Croatian: U ukupno 467 pedijatrijskih bolesnika koji su u kliničkim ispitivanjima inicijalno randomizirani za primanje duloksetina, zabilježena je srednja vrijednost smanjenja tjelesne težine od 0,1 kg u 10. tjednu, u usporedbi sa srednjom vrijednošću porasta težine od 0,9 kg u 353 bolesnika koja su primala placebo.
English: What you need to know before you take Duloxetine Mylan
Croatian: Što morate znati prije nego počnete uzimati lijek Duloxetine Mylan
English: Tolerability of duloxetine 60 mg once daily in elderly patients was comparable to that seen in the younger adults.
Croatian: Podnošljivost duloksetina u dozi od 60 mg jednom dnevno u starijih bolesnika bila je usporediva s onom koja je uočena u mlađih odraslih osoba.
English: Duloxetine Mylan is indicated in adults.
Croatian: Duloxetine Mylan je indiciran kod odraslih.
English: The initiation of treatment with Duloxetine Mylan is contraindicated in patients with uncontrolled hypertension that could expose patients to a potential risk of hypertensive crisis (see sections 4.4 and 4.8).
Croatian: Kontraindicirano je započeti liječenje lijekom Duloxetine Mylan u bolesnika s nekontroliranom hipertenzijom koja bolesnika može izložiti potencijalnom riziku od hipertenzivne krize (vidjeti dijelove 4.4 i 4.8).
English: Generalised Anxiety Disorder: Duloxetine demonstrated statistically significant superiority over placebo in five out of five studies including four randomised, double-blind, placebo-controlled acute studies and a relapse prevention study in adult patients with generalised anxiety disorder.
Croatian: Generalizirani anksiozni poremećaj: duloksetin se pokazao statistički značajno superiornijim u odnosu na placebo u pet od pet provedenih ispitivanja, od kojih su četiri bila randomizirana, dvostruko slijepa, placebom kontrolirana kratkoročna ispitivanja, a jedno ispitivanje prevencije relapsa u odraslih bolesnika s generaliziranim anksioznim poremećajem.
English: A single study has been performed in paediatric patients with juvenile primary fibromyalgia syndrome (JPFS) in which the duloxetine-treated group did not separate from placebo group for the primary efficacy measure.
Croatian: Provedeno je jedno ispitivanje u pedijatrijskih bolesnika s juvenilnim sindromom primarne fibromialgije (engl. juvenile primary fibromyalgia syndrome, JPFS), u kojem se rezultati primarne mjere ishoda za djelotvornost u skupini liječenoj duloksetinom nisu razlikovali od onih u skupini koja je primala placebo.
English: What Duloxetine Mylan looks like and contents of the pack Duloxetine Mylan is hard gastro-resistant capsule.
Croatian: Kako Duloxetine Mylan izgleda i sadržaj pakiranja Duloxetine Mylan je tvrda želučanootporna kapsula.
English: Consequently, caution is advised when Duloxetine Mylan is taken in combination with other centrally acting medicinal products or substances, including alcohol and sedative medicinal products (e.g. benzodiazepines, morphinomimetics, antipsychotics, phenobarbital, sedative antihistamines).
Croatian: Stoga se preporučuje oprez kada se Duloxetine Mylan primjenjuje u kombinaciji s drugim lijekovima i tvarima koje djeluju na SŽS, uključujući alkohol i sedative (npr. benzodiazepine, morfinomimetike, antipsihotike, fenobarbital, sedativne antihistaminike).
English: The study included a 13-week double-blind period where patients were randomised to duloxetine 30 mg/60 mg, or placebo daily.
Croatian: Ispitivanje je uključivalo 13-tjedno dvostruko slijepo razdoblje u kojem su bolesnici bili randomizirani na dnevno primanje ili duloksetina u dozi od 30 mg/60 mg ili placeba.
English: What Duloxetine Mylan contains
Croatian: Što Duloxetine Mylan sadrži
English: Hepatitis Elevated liver enzymes (ALT, AST, alkaline phosphatase) Acute liver injury
Croatian: Poremećaji jetre i žuči hepatitis povišene vrijednosti jetrenih enzima (ALT, AST, alkalna fosfataza) akutno oštećenje jetre zatajenje jetre žutica
English: Duloxetine Mylan should not be used in combination with fluvoxamine, ciprofloxacin or enoxacin (i.e. potent CYP1A2 inhibitors) since the combination results in elevated plasma concentrations of duloxetine (see section 4.5).
Croatian: Duloxetine Mylan se ne smije primjenjivati u kombinaciji s fluvoksaminom, ciprofloksacinom ili enoksacinom (tj. potentnim inhibitorima CYP1A2) jer se pri toj kombinaciji povećava koncentracija duloksetina u plazmi (vidjeti dio 4.5).