FrancophonIA/ELRC3.0 huggingface dataset:
English: In addition to routine adverse event reporting, pre-specified event categories, adjudicated by an independent expert committee, were examined in two placebo-controlled safety studies in which patients received parecoxib for at least 3 days and then were transitioned to oral valdecoxib for a total duration of 10-14 days.
Croatian: Uz rutinsko prijavljivanje štetnih događaja, u dva placebom kontrolirana ispitivanja sigurnosti primjene u kojima su bolesnici primali parekoksib tijekom najmanje 3 dana i potom su bili prebačeni na oralni valdekoksib tijekom ukupno 10-14 dana bile su ispitane unaprijed specificirane kategorije događaja, prema prosudbi neovisnog stručnog odbora.
English: In clinical trials, the daily requirement for PRN opioids was significantly reduced when coadministered with parecoxib.
Croatian: U kliničkim je ispitivanjima dnevna potreba za opioidima koji se uzimaju po potrebi bila značajno snižena kad se istodobno primjenjivao parekoksib.
English: Following single IV and IM doses of parecoxib 20 mg, Cmax of valdecoxib is achieved in approximately 30 minutes and approximately 1 hour, respectively.
Croatian: Nakon jednokratne i.v. doze parekoksiba od 20 mg, Cmax valdekoksiba postiže se u roku od približno 30 minuta, a u roku od približno 1 sata nakon i.m. primjene parekoksiba u dozi od 20 mg.
English: Use aseptic technique to reconstitute lyophilised parecoxib (as parecoxib).
Croatian: Koristite se aseptičkom tehnikom za rekonstituciju liofiliziranog parekoksiba (u obliku parekoksibnatrija).
English: This interaction should be given consideration in patients receiving parecoxib concomitantly with ACE-inhibitors, angiotensin II antagonists, beta-blockers and diuretics.
Croatian: Tu interakciju potrebno je uzeti u obzir u bolesnika koji primaju parekoksib istodobno s ACE-inhibitorima, antagonistima angiotenzina II, beta-blokatorima i diureticima.
English: Coadministration of valdecoxib with glibenclamide (CYP3A4 substrate) did not affect either the pharmacokinetics (exposure) or the pharmacodynamics (blood glucose and insulin levels) of glibenclamide.
Croatian: Istodobna primjena valdekoksiba s glibenklamidom (supstrat CYP3A4) nije utjecala ni na farmakokinetiku (izloženost), niti na farmakodinamiku (razine glukoze i inzulina u krvi) glibenklamida.
English: Very common: may affect more than 1 in 10 people ▪ Nausea (feeling sick)
Croatian: Vrlo često: mogu se javiti u više od 1 na 10 osoba
English: Inflammatory bowel disease.
Croatian: Upalna bolest crijeva.
English: In post-marketing experience, toxic epidermal necrolysis has been reported in association with the use of valdecoxib, and cannot be ruled out for parecoxib (see section 4.4).
Croatian: U iskustvu nakon stavljanja u promet zabilježena je toksična epidermalna nekroliza povezana s primjenom valdekoksiba, koja se ne može isključiti za parekoksib (vidjeti dio 4.4).
English: The reduction in opioid use with Dynastat treatment on Days 2 and 3 was 7.2 mg and 2.8 mg (37% and 28% respectively).This reduction in opioid use was accompanied by significant reductions in patient-reported opioid symptom distress.
Croatian: Smanjenje primjene opioida uz liječenje Dynastatom 2. i 3. dana iznosilo je 7,2 mg i 2,8 mg (37% odnosno 28%).
English: Use of parecoxib beyond 3 days
Croatian: Primjena parekoksiba dulja od 3 dana
English: Administration of IV parecoxib 40 mg had no significant effect on the pharmacokinetics of either IV fentanyl or IV alfentanil (CYP3A4 substrates).
Croatian: Primjena i.v. parekoksiba u dozi od 40 mg nije imala značajnog učinka na farmakokinetiku ni i.v. fentanila, niti i.v. alfentanila (supstrati CYP3A4).
English: In a placebo-controlled, orthopedic and general surgery study (n =1050), patients received Dynastat at an initial parenteral dose of 40 mg IV followed by 20 mg twice daily for a minimum of 72 hours in addition to receiving standard care including supplemental patient controlled opioids.
Croatian: U placebom kontroliranom ispitivanju primjene kod ortopedskih i općih kirurških zahvata (n =1050), bolesnici su primali Dynastat u početnoj parenteralnoj dozi od 40 mg i.v. nakon koje je slijedilo 20 mg dvaput dnevno tijekom najmanje 72 sata uz primanje standardne skrbi koja je uključivala dodavanje opioida po potrebi i pod kontrolom bolesnika.
English: 1 + 1 pack: contains 1 powder vial and 1 solvent ampoule.
Croatian: Pakiranje 1+1: sadrži 1 bočicu s praškom i 1 ampulu s otapalom.
English: The IV bolus injection may be given rapidly and directly into a vein or into an existing IV line.
Croatian: I.v. bolus injekcija može se dati brzo i izravno u venu ili postojeću i.v. liniju.
English: Additionally, coadministration of valdecoxib had no clinically significant effect on the hepatic or intestinal CYP 3A4-mediated metabolism of orally administered midazolam.
Croatian: Osim toga, istodobna primjena valdekoksiba nije imala klinički značajan utjecaj na metabolizam oralno primijenjenog midazolama posredovan CYP3A4 u jetri ili crijevima.
English: Reconstitution process
Croatian: Postupak rekonstitucije
English: In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors or Angiotensin-II antagonists, may result in further deterioration of renal function, including possible acute renal failure.
Croatian: U bolesnika koji su starije dobi, imaju depleciju volumena (uključujući one na terapiji diureticima) ili kompromitiranu funkciju bubrega, istodobna primjena nesteroidnih protuupalnih lijekova, uključujući selektivne inhibitore COX-2 s inhibitorima angiotenzin konvertirajućeg enzima (ACE) ili antagonistima angiotenzina-II, može rezultirati daljnjim pogoršanjem funkcije bubrega, uključujući moguće akutno zatajenje bubrega.
English: As the cardiovascular risk of COX-2 specific inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Croatian: Budući da se kardiovaskularni rizik specifičnih inhibitora COX-2 može povećavati s dozom i trajanjem izloženosti, mora ih se primjenjivati u najnižoj učinkovitoj dnevnoj dozi u što kraćem trajanju.
English: For instructions on reconstitution of the medicinal product before administration, see section 6.6.
Croatian: Za upute o rekonstituciji lijeka prije primjene vidjeti dio
English: Inhibition of prostaglandins by NSAIDs, including COX-2 inhibitors, may diminish the effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin II antagonists, beta-blockers and diuretics.
Croatian: Inhibicija prostaglandina nesteroidnim protuupalnim lijekovima, uključujući COX-2 inhibitore, može umanjiti učinke inhibitora angiotenzin konvertirajućeg enzima (ACE), antagonista angiotenzina II, beta-blokatora i diuretika.
English: For more information on storage see the package leaflet.
Croatian: Za dodatne informacije o čuvanju, vidjeti uputu o lijeku.
English: The efficacy of Dynastat was established in studies of dental, gynaecologic (hysterectomy), orthopaedic (knee and hip replacement), and coronary artery bypass graft surgical pain.
Croatian: Djelotvornost Dynastata ustanovljena je u ispitivanjima kod kirurške boli nakon stomatoloških, ginekoloških (histerektomija), ortopedskih (zamjena koljena i kuka) operacija i operacija ugradnje aortokoronarne premosnice.
English: 5 vials and 5 solvent ampoules
Croatian: 5 bočica i 5 ampula s otapalom
English: Solvent for Dynastat 40 mg
Croatian: Otapalo za Dynastat 40 mg
English: Cases of severe hypotension shortly following parecoxib administration have been reported in postmarketing experience with parecoxib.
Croatian: Slučajevi teške hipotenzije ubrzo nakon primjene parekoksiba zabilježeni su iz iskustva s parekoksibom nakon stavljanja lijeka u promet.
English: The recommended dose is 40 mg administered intravenously (IV) or intramuscularly (IM), followed every 6 to 12 hours by 20 mg or 40 mg as required, not to exceed 80 mg/day.
Croatian: Preporučena doza je 40 mg primijenjena intravenski (i.v.) ili intramuskularno (i.m.), nakon koje se svakih 6 do 12 sati daje 20 mg ili 40 mg po potrebi, s time da ne smije premašiti 80 mg/dan.
English: Patients should be adequately hydrated and the need to monitor the renal function should be assessed at the beginning of the concomitant treatment and periodically thereafter.
Croatian: Bolesnici moraju biti primjereno hidrirani te na početku i periodički nakon početka istodobnog liječenja potrebno je procijeniti potrebu nadzora funkcije bubrega.
English: In isolated cases, an aggravation of soft tissue infections has been described in connection with the use of NSAIDs and in nonclinical studies with Dynastat (see section 5.3).
Croatian: U izoliranim slučajevima i u nekliničkim ispitivanjima Dynastata opisano je pogoršanje infekcije mekih tkiva povezano s primjenom nesteroidnih protuupalnih lijekova (vidjeti dio 5.3).
English: The powder is contained in colourless glass vials (5 ml) with a stopper, sealed with a purple flip-off cap on the aluminium overseal.
Croatian: Prašak se nalazi u bočicama od bezbojnog stakla (5 ml) s čepom, zatvorenima ljubičastim „flip-off“ zatvaračem preko aluminijskog prstena.
English: VIAL LABEL: 40 mg
Croatian: NALJEPNICA BOČICE: 40 mg
English: - if you have established heart disease and /or cerebrovascular disease e.g. if you have had a heart attack, stroke, mini-stroke (TIA) or blockages to blood vessels to the heart or brain or an operation to clear or bypass blockages - if you have or have had problems with your blood circulation (peripheral arterial disease)
Croatian: • ako su Vam ustanovili srčanu bolest i/ili cerebrovaskularnu bolest, npr. ako ste imali srčani udar, moždani udar, mali moždani udar (TIA) ili začepljenje krvnih žila srca ili mozga ili operaciju zbog uklanjanja ili zaobilaženja mjesta začepljenja
English: Exposure to parecoxib was similar after IV or IM administration in terms of AUC.
Croatian: Izloženost parekoksibu bila je slična nakon i.v. i i.m. primjene u pogledu AUC.
English: Dynastat must not be administered to women who breast-feed (see section 4.3).
Croatian: Dynastat se ne smije primjenjivati u dojilja (vidjeti dio 4.3).
English: Therefore, the concomitant administration of these drugs should be done with caution.
Croatian: Stoga, potreban je oprez prilikom istodobne primjene ovih lijekova.
English: The reconstituted solution must not be used if discoloured or cloudy or if particulate matter is observed.
Croatian: Rekonstituirana otopina ne smije se primijeniti ako je promijenila boju ili je zamućena ili ako se vide čestice.
English: The solvent is contained in colourless neutral glass ampoules (2 ml).
Croatian: Otapalo se nalazi u ampulama (2 ml) od bezbojnog neutralnog stakla.
English: Valdecoxib is not removed by haemodialysis.
Croatian: Valdekoksib se ne uklanja hemodijalizom.
English: Excipient with known effect This medicinal product contains less than 1 mmol sodium (23 mg) per dose.
Croatian: Ovaj lijek sadrži manje od 1 mmol natrija (23 mg) po dozi.
English: This medicine does not require any special storage conditions prior to reconstitution.
Croatian: Ovaj lijek ne zahtijeva posebne uvjete čuvanja prije pripreme za primjenu.
English: This medicinal product contains less than 1 mmol sodium (23 mg) per dose, and is therefore considered essentially ‘sodium- free'.
Croatian: Ovaj lijek sadrži manje od 1 mmol natrija (23 mg) po dozi, tj. zanemarive količine natrija.
English: General surgery
Croatian: Opća kirurgija
English: Circulatory collapse, congestive heart failure, tachycardia
Croatian: Srčani poremećaji infarkt miokarda, bradikardija cirkulatorni kolaps, kongestivno zatajenje srca, tahikardija
English: Therefore, caution should be observed when administering Dynastat with medicinal products known to be substrates of CYP2C19 (e.g. phenytoin, diazepam, or imipramine).
Croatian: Stoga se primjeni Dynastata s lijekovima za koje se zna da su supstrati CYP2C19 (npr. feniton, diazepam ili imipramin) mora pristupiti s oprezom.
English: Additionally, fatal reports of toxic epidermal necrolysis have been reported through postmarketing surveillance in patients receiving valdecoxib (the active metabolite of parecoxib) and cannot be ruled out for parecoxib (see section 4.8).
Croatian: Uz to su tijekom praćenja lijeka nakon stavljanja u promet zabilježeni smrtni slučajevi zbog toksične epidermalne nekrolize u bolesnika koji su primali valdekoksib (djelatni metabolit parekoksiba) i ne mogu se isključiti za parekoksib (vidjeti dio 4.8).
English: • Ringer-Lactate solution for injection.
Croatian: • otopina Ringerovog laktata za injekciju.
English: Patients were randomized within 24-hours post-CABG surgery to: parecoxib initial dose of 40 mg IV, then 20 mg IV Q12H for a minimum of 3 days followed by valdecoxib PO (20 mg Q12H) (n=544) for the remainder of a 10 day treatment period; placebo IV followed by valdecoxib PO (n=544); or placebo IV followed by placebo PO (n=548).
Croatian: Bolesnici su bili randomizirani u roku od 24 sata nakon operacije ugradnje aortokoronarne premosnice u sljedeće skupine: parekoksib u početnoj dozi od 40 mg i.v., potom 20 mg i.v. svakih 12h tijekom najmanje 3 dana nakon čega je slijedio valdekoksib p.o. (20 mg svakih 12h) (n=544) tijekom preostalog 10-dnevnog razdoblja liječenja; placebo i.v. nakon kojeg je slijedio valdekoksib p.o. (n=544); ili placebo i.v. nakon kojeg je slijedio placebo p.o. (n=548).
English: After reconstitution with 2 ml of solvent, the concentration of parecoxib is 20 mg/ml.
Croatian: Nakon pripreme za primjenu s 2 ml otapala, koncentracija parekoksiba je 20 mg/ml.
English: Psychiatric disorders Agitation, insomnia Nervous system disorders Hypoaesthesia, dizziness
Croatian: Psihijatrijski poremećaji: agitacija, nesanica Poremećaji živčanog sustava hipoestezija, omaglica cerebrovaskularni poremećaj
English: In the second CABG surgery study, four pre-specified event categories were evaluated (cardiovascular/thromboembolic; renal dysfunction/renal failure; upper GI ulcer/bleeding; surgical wound complication).
Croatian: U drugom ispitivanju kod operacije ugradnje aortokoronarne premosnice procjenjivane su četiri unaprijed određene kategorije događaja (kardiovaskularni/tromboembolijski; poremećaj funkcije bubrega/zatajenje bubrega; ulkus/krvarenje iz gornjeg dijela gastrointestinalnog sustava; komplikacije kirurške rane).
English: Cardiac disorders
Croatian: Kardiovaskularni učinci
English: The IV line must be adequately flushed prior to and after Dynastat injection with a solution of known compatibility (see section 6.6).
Croatian: Dynastat se ne smije ubrizgavati u i.v. liniju kojom se daje neki drugi lijek. i.v. linija mora se primjereno isprati prije i nakon injekcije Dynastata otopinom za koju se zna da je kompatibilna (vidjeti dio 6.6).
English: As the cardiovascular risk of cyclooxygenase-2 (COX-2) specific inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Croatian: Budući da se kardiovaskularni rizik koji nose specifični inhibitori ciklooksigenaze-2 (COX-2) može povećati s dozom i trajanjem izloženosti, mora se primjenitit najniža učinkovita doza tijekom najkraćeg mogućeg razdoblja.
English: 1 vial and 1 solvent ampoule
Croatian: 1 bočica i 1 ampula s otapalom
English: There were no significant differences in the overall safety profile, including the four pre-specified event categories described above for the second CABG surgery study, for parecoxib/valdecoxib compared to placebo treatment in these post-surgical patients.
Croatian: U ovih bolesnika nakon operacije nije bilo značajnih razlika u ukupnom sigurnosnom profilu između liječenja parekoksibom/valdekoksibom i placeba, uključujući i četiri unaprijed definirane kategorije događaja opisane gore za drugo ispitivanje kod operacije ugradnje aortokoronarne premosnice.
English: Exposure of valdecoxib following single doses of Dynastat, as measured by both the area under the plasma concentration vs. time curve (AUC) and peak concentration (Cmax), is approximately linear in the range of clinical doses.
Croatian: Prema izmjerenoj površini ispod krivulje koncentracije u plazmi naspram vremena (AUC) i vršne koncentracije (Cmax), izloženost valdekoksibu nakon jednokratnih doza Dynastata približno je linearna u rasponu kliničkih doza.
English: 3 vials and 3 solvent ampoules
Croatian: 3 bočice i 3 ampule s otapalom
English: Pregnancy, breast-feeding and fertility ▪ If you are pregnant or trying to become pregnant, tell your doctor.
Croatian: • Ako ste trudni ili pokušavate zatrudnjeti, obavijestite svog liječnika.
English: Vascular disorders Hypertension, hypotension
Croatian: Krvožilni poremećaji hipertenzija, hipotenzija hipertenzija (pogoršana), ortostatska hipotenzija
English: Asthenia, injection site pain, injection site reaction
Croatian: • bol na mjestu primjene injekcije ili reakcija na mjestu primjene injekcije
English: Withdraw with a sterile needle and syringe, 2 ml of an acceptable solvent and insert the needle through the central portion of the rubber stopper transferring the solvent into the parecoxib 40 mg vial.
Croatian: Izvucite sterilnom iglom i štrcaljkom 2 ml prihvatljivog otapala i uvedite iglu kroz središnji dio gumenog čepa te prenesite otapalo u bočicu s 40 mg parekoksiba.
English: Hypersensitivity reactions (anaphylaxis and angioedema) have been reported in post-marketing experience with valdecoxib and parecoxib (see section 4.8).
Croatian: Reakcije preosjetljivosti (anafilaksija i angioedem) na valdekoksib i parekoksib zabilježene su tijekom praćenja tih lijekova nakon stavljanja u promet (vidjeti dio 4.8).
English: When reconstituted in sodium chloride 9 mg/ml (0.9%) solution, Dynastat contains approximately 0.44 mmol of sodium per vial.
Croatian: Kad se rekonstituira u otopini natrijevog klorida od 9 mg/ml (0,9%), Dynastat sadrži približno 0,44 mmola natrija po bočici.
English: Sodium chloride 9 mg/ml (0.9%) solution
Croatian: Otopina natrijevog klorida od 9 mg/ml (0,9%)
English: When reconstituted in sodium chloride 9 mg/ml (0.9%) solution, Dynastat contains approximately 0.44 mEq of sodium per vial.
Croatian: Kad se priprema za primjenu s otopinom natrijevog klorida 9 mg/ml (0,9%), Dynastat sadrži približno 0,44 mEq natrija po bočici.
English: Powder for solution for injection
Croatian: Prašak za otopinu za injekciju
English: or patients who may be predisposed to fluid retention, parecoxib should be initiated at the lowest recommended dose (20 mg) and the patient's kidney function should be closely monitored (see sections 4.4 and 5.2).
Croatian: U bolesnika s teškim oštećenjem bubrega (klirens kreatinina < 30 ml/min) ili u bolesnika koji mogu biti skloni zadržavanju tekućine, primjena parekoksiba mora se započeti u najnižoj preporučenoj dozi (20 mg), a funkcija bubrega bolesnika mora se pažljivo nadzirati (vidjeti dijelove 4.4 i 5.2).
English: 40 mg vial: Remove the purple flip-off cap to expose the central portion of the rubber stopper of the parecoxib 40 mg vial.
Croatian: Bočica od 40 mg: Uklonite ljubičasti “flip-off“ zatvarač kako biste izložili središnji dio gumenog čepa bočice parekoksiba od 40 mg.
English: • sodium chloride 9 mg/ml (0.9%) solution for injection/infusion;
Croatian: • otopina natrijevog klorida 9 mg/ml (0,9%) za injekciju/infuziju;
English: Dynastat has been studied in dental, orthopaedic, gynaecologic (principally hysterectomy) and coronary artery bypass graft surgery.
Croatian: Dynastat je ispitan kod stomatoloških, ortopedskih i ginekoloških operacija (prvenstveno histerektomije) te operacije ugradnje aortokoronarne premosnice.
English: Serious skin reactions are known to occur with NSAIDs including COX-2 selective inhibitors as well as other medicinal products.
Croatian: Poznato je da uz primjenu nesteroidnih protuupalnih lijekova, uključujući selektivne inhibitore COX-2 i druge lijekove, nastaju ozbiljne kožne reakcije.
English: The magnitude of analgesic effect of the 40 mg dose was comparable with that of ketorolac 60 mg IM or ketorolac 30 mg IV. After a single dose, the duration of analgesia was dose and clinical pain model dependent, and ranged from 6 to greater than 12 hours.
Croatian: Veličina analgetskog učinka doze od 40 mg bila je usporediva s učinkom ketorolaka u dozi od 60 mg i.m. ili ketorolaka u dozi od 30 mg i.v.
English: • Use of Ringer-Lactate solution for injection or glucose 50 mg/ml (5%) in Ringer-Lactate solution for injection for reconstitution will cause the parecoxib to precipitate from solution and therefore is not recommended.
Croatian: • Primjena Ringerovog laktata za injekciju ili glukoze od 50 mg/ml (5%) u Ringerovom laktatu za injekciju za rekonstituciju prouzročit će precipitaciju parekoksiba iz otopine te se stoga ne preporučuje.
English: The first CABG surgery study evaluated patients treated with IV parecoxib 40 mg bid for a minimum of 3 days, followed by treatment with valdecoxib 40 mg bid (parecoxib/valdecoxib group) (n=311) or placebo/placebo (n=151) in a 14-day, double-blind placebo-controlled study.
Croatian: U prvom su 14-dnevnom, dvostruko slijepom, placebom kontroliranom ispitivanju primjene kod operacije ugradnje aortokoronarne premosnice bolesnici bili liječeni i.v. parekoksibom 40 mg bid tijekom najmanje 3 dana, nakon čega je slijedilo liječenje valdekoksibom 40 mg bid (parekoksib/valdekoksib skupina) (n=311) ili placebom/placebom (n=151).
English: Cerebrovascular disorder
Croatian: Oštećenje bubrega
English: Each 2 ml of reconstituted powder contains 40 mg of parecoxib.
Croatian: Svaka 2 ml rekonstituiranog praška sadrže 40 mg parekoksiba.
English: Use of Ringer-Lactate solution for injection or glucose 50 mg/ml (5%) in Ringer Lactate solution for injection for reconstitution will cause the parecoxib to precipitate from solution and therefore is not recommended.
Croatian: Primjena otopine Ringerovog laktata za injekciju ili glukoze od 50 mg/ml (5%) u otopini Ringerovog laktata za injekciju za rekonstituciju izazvat će precipitaciju parekoksiba iz otopine pa se stoga ne preporučuje.
English: This medicinal product does not require any special storage conditions prior to reconstitution.
Croatian: Ovaj ljek ne zahtijeva posebne uvjete čuvanja prije pripreme za primjenu.
English: • sodium chloride 9 mg/ml (0.9%) solution for injection/infusion
Croatian: • otopina natrijevog klorida 9 mg/ml (0,9%) za injekciju/infuziju
English: - if you have had a serious allergic reaction (especially a serious skin reaction) to any medicines - if you have had an allergic reaction to a group of medicines called “sulfonamides” (e.g. some antibiotics used to treat infections) - if you currently have a gastric or intestinal ulcer or bleeding in the stomach or gut - if you have had an allergic reaction to acetylsalicylic acid (aspirin) or to other NSAIDs (e.g.
Croatian: • ako ste imali alergijsku reakciju na skupinu lijekova koji se zovu “sulfonamidi” (npr. neki antibiotici koji se primjenjuju za liječenje infekcija)
English: Powder vial: Each vial contains 40 mg parecoxib (as 42.36 mg parecoxib sodium).
Croatian: Bočica s praškom: Svaka bočica sadrži 40 mg parekoksiba (u obliku 42,36 mg parekoksibnatrija).
English: After reconstitution with acceptable solvents, Dynastat may only be injected IV or IM, or into IV lines delivering:
Croatian: Nakon rekonstitucije s prihvatljivim otapalima, Dynastat se smije injicirati samo i.v. ili i.m. ili u i.v. linije kojima se daju:
English: Hypertension (aggravated), orthostatic hypotension Respiratory, thoracic and mediastinal disorders Respiratory insufficiency
Croatian: Krvožilni poremećaji hipertenzija, hipotenzija hipertenzija (pogoršana), ortostatska hipotenzija Poremećaji dišnog sustava, prsišta i sredoprsja respiratorna insuficijencija plućna embolija dispneja
English: Hydrochloric acid or sodium hydroxide (for pH adjustment) Water for injection.
Croatian: Otapalo natrijev klorid kloridna kiselina ili natrijev hidroksid (za podešavanje pH) voda za injekciju