FrancophonIA/ELRC3.0 huggingface dataset:
English: Considering the limited safety database, the adverse events thus far reported in children and adolescents are consistent with the known safety profile in adult patients with Ph+ ALL.
Danish: Under hensyntagen til den begrænsede sikkerhedsdatabase er de bivirkninger, der hidtil er rapporteret hos børn og unge, i overensstemmelse med den kendte sikkerhedsprofil for voksne patienter med Ph+ ALL.
English: Imatinib Accord can reduce the number of white blood cells, so you might get infections more easily.
Danish: Imatinib Accord kan nedsætte antallet af hvide blodlegemer, så du lettere kan få infektioner.
English: No specific dose recommendation is necessary in elderly.
Danish: Specifik dosisjustering er ikke nødvendig til ældre.
English: While you are taking Imatinib Accord, your doctor will regularly check whether the medicine is working.
Danish: Mens du tager Imatinib Accord, vil din læge regelmæssigt kontrollere, om lægemidlet virker.
English: Patients should be tested for HBV infection before initiating treatment with Imatinib Accord.
Danish: Patienten bør testes for HBV-infektion før initiering af behandling med Imatinib Accord.
English: In all clinical studies 38-40% of patients were > 60 years of age and 10-12% of patients were > 70 years of age.
Danish: I de kliniske undersøgelser var 38-40% af patienterne 60 år, og 10-12% af patienterne var 70 år.
English: Importantly, 27.7% of patients also achieved a major cytogenetic response, which was complete in 20.4% (confirmed 16%) of patients.
Danish: Væsentligt er det, at 27,7 % af patienterne også opnåede et cytogenetisk hovedrespons, hvilket var fuldstændigt hos 20,4 % (bekræftet 16 %) af patienterne.
English: Caution should therefore be exercised when using high doses of imatinib and paracetamol concomitantly.
Danish: Der rådes derfor til forsigtighed, når høje doser Imatinib og paracetamol anvendes samtidig.
English: Imatinib n=553
Danish: n=553
English: The degree of cytogenetic response and molecular response had a clear effect on long-term outcomes in patients on Imatinib.
Danish: Graden af cytogenisk respons og molekylært respons havde en klar effekt på langtidsudfaldet for patienter i Imatinib-behandling.
English: The annual rate of progression to accelerated phase or blast crisis decreased with time on therapy and was less than 1% annually in the fourth and fifth years.
Danish: Den årlige frekvens for progression til fremskreden fase eller blastkrise aftog, jo længere behandlingen stod på, og var mindre end 1 % årlig i fjerde og femte år.
English: Severe elevation of transaminases (< 5%) or bilirubin (< 1%) was seen in CML patients and was usually managed with dose reduction or interruption (the median duration of these episodes was approximately one week).
Danish: Svære stigninger i transaminaser (<5%) eller bilirubin (<1%) blev observeret hos CML-patienterne og blev sædvanligvis behandlet med dosisreduktion eller seponering (den gennemsnitlige varighed af disse episoder var ca. 1 uge).
English: For patients with reduction in Bcr-Abl transcripts of at least 3 logarithms at 12 months, the probability of remaining free from progression to accelerated phase/blast crisis was 99% at 84 months.
Danish: For patienter med reduktion i Bcr-Abl transkripter på mindst 3 logaritmer ved 12 måneder, var sandsynligheden for at forblive fri for progression til accelereret fase/blastkrise 99 % efter 84 måneder.
English: The median duration of second-line treatment with Imatinib was 64 months.
Danish: Medianvarigheden af andenlinjebehandling med Imatinib var 64 måneder.
English: A confirmed haematological response was achieved in 71.5% of patients (Table 3).
Danish: Der opnåedes konfirmeret hæmatologisk respons hos 71,5 % af patienterne (Tabel 3).
English: 319 Pinner Road North Harrow Middlesex, HA1 4HF United Kingdom
Danish: 319 Pinner Road North Harrow, Middlesex, HA1 4HF Storbritannien
English: Healthcare professionals are asked to report any suspected adverse reactionsvia the national reporting system listed in Appendix V.
Danish: Læger og sundhedspersonale anmodes om at indberette alle formodede bivirkninger via det nationale rapporteringssystem anført i Appendiks V.
English: Resume treatment with Imatinib Accord at previous dose (i.e. before severe adverse reaction).
Danish: Genoptag Imatinib Accord-behandlingen ved den tidligere dosis (dvs. før svære bivirkninger).
English: Do not stop taking Imatinib Accord unless your doctor tells you to.
Danish: Du må ikke stoppe med at tage Imatinib Accord, medmindre din læge fortæller dig det.
English: If you have any questions about how Imatinib Accord works or why this medicine has been prescribed for you, ask your doctor.
Danish: Hvis du har spørgsmål om, hvordan Imatinib Accord virker, eller hvorfor du har fået ordineret dette lægemiddel, kontakt din læge.
English: The doctor will tell you how many tablets of Imatinib Accord to give to your child.
Danish: Lægen vil fortælle dig, hvor mange Imatinib Accord-tabletter, du skal give dit barn.
English: In contrast, there were 165 (29.8%) events in the IFN+Ara-C arm, of which 130 occurred during first-line treatment with IFN+Ara-C.
Danish: Til sammenligning var der 165 (29,8 %) hændelser i IFN+Ara-C-armen, af hvilke 130 opstod under førstevalgsbehandling med IFN+Ara-C.
English: • For Alu/Alu blisters This medicine does not require any special storage conditions.
Danish: • Alu/alu-blister: Dette lægemiddel kræver ingen særlige forholdsregler vedrørende opbevaringen.
English: If you are being treated for HES/CEL
Danish: Hvis du behandles for HES/CEL
English: Blast crisis is defined as blasts ≥ 30% in blood or bone marrow or extramedullary disease other than hepatosplenomegaly.
Danish: Blastkrise defineres som ≥30 % blaster i blod eller knoglemarv eller ekstramedullær sygdom ud over hepatosplenomegali.
English: There were 59% males and 41% females; 89.9% caucasian and 4.7% black patients.
Danish: 59 % var mænd, 41 % kvinder; 89,9 % var af kaukatisk afstamning og 4,7 % af negroid afstamning.
English: Imatinib Accord will only be prescribed to you by a doctor with experience in medicines to treat blood cancers or solid tumours.
Danish: Imatinib Accord vil kun blive ordineret til dig af en læge med erfaring i behandlingen af kræft i blodet eller kræftknuder.
English: The active substance imatinib demonstrates an environmental risk for sediment organisms.
Danish: Det aktive stof imatinib viser en miljørisiko for sedimentlevende organismer
English: In this study 65% of the patients achieved a major cytogenetic response that was complete in 53% (confirmed 43%) of patients (Table 3).
Danish: I denne undersøgelse opnåede 65 % af patienterne et cytogenetisk hovedrespons, som var fuldstændigt hos 53 % (bekræftet 43 %) af patienterne (Tabel 3).
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR BLISTER
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE KARTON TIL BLISTER
English: If anti-ADAMTS13-antibody is elevated in conjunction with low ADAMTS13 activity, treatment with Imatinib Accord should not be resumed.
Danish: Hvis niveauet af ADAMTS13antistoffer er forøget samtidig med lav ADAMTS13-aktivitet, må behandlingen med Imatinib Accord ikke genoptages.
English: - if you experience bruising, bleeding, fever, fatigue and confusion when taking Imatinib Accord, contact your doctor.
Danish: - hvis du får blå mærker, blødninger, feber, træthed og oplever forvirring, mens du tager Imatinib Accord, skal du kontakte din læge.
English: Based on population pharmacokinetic analysis in CML patients, there was a small effect of age on the volume of distribution (12% increase in patients > 65 years old).
Danish: Populationsfarmakokinetiske analyser hos CML-patienter har vist, at alder har en lille effekt på fordelingsvolumen (12% stigning hos patienter 65 år).
English: Your doctor will discuss with you the possible risks of taking Imatinib Accord during pregnancy.
Danish: Din læge vil fortælle dig om de mulige risici, der er forbundet med brug af Imatinib Accord under graviditeten.
English: The rate ofresponse was also higher in the patients treated at 600 mg (33%) as compared to the patients treated at 400 mg (16%, p=0.0220).
Danish: Hovedresponsniveauet var også større hos patienter behandlet med 600 mg (33%) sammenlignet med patienter behandlet med 400 mg (16%, p=0,0220).
English: Some medicines can interfere with the effect of Imatinib Accord when taken together.
Danish: Nogle lægemidler kan påvirke virkningen af Imatinib Accord, når de bruges samtidigt.
English: Major molecular response criteria: in the peripheral blood reduction of ≥ 3 logarithms in the amount of Bcr-Abl transcripts (measured by real-time quantitative reverse transcriptase PCR assay) over a standardised baseline.
Danish: Molekulær major responskriterier: I den perifere blodreduktion på ≥3 logaritmer i antallet af BcrABL-transkriptioner (målt ved real-time kvantitativ reverse transkriptase PCR assay) over for en standardiserede baseline.
English: Patients had received a median of 14 months of prior IFN therapy at doses ≥ 25 x 106 IU/week and were all in late chronic phase, with a median time from diagnosis of 32 months.
Danish: Patienterne havde i gennemsnit tidligere modtaget 14 måneders IFNbehandling med doser 25 x 106 IU/uge og var alle i sen kronisk fase med en gennemsnitlig tid siden diagnose på 32 måneder.
English: The effect of imatinib on the outcome of bone marrow transplantation has not been determined.
Danish: Effekten af imatinib på resultatet af knoglemarvstransplantation er ikke blevet bestemt.
English: Progression was defined as any of the following events: progression to accelerated phase or blast crisis, death, loss of CHR or MCyR, or in patients not achieving a CHR an increasing WBC despite appropriate therapeutic management.
Danish: Progression blev defineret som enhver af følgende hændelser: progression til accellereret fase eller blastkrise, død, tab af CHR eller MCyR, eller patienter der ikke opnår CHR eller øget leukocyttal på trods af relevant terapeutisk behandling.
English: However, some of these reactions may be serious or life-threatening and several patients with blast crisis died with a complex clinical history of pleural effusion, congestive heart failure and renal failure.
Danish: I nogle tilfælde kan disse tilstande dog være alvorlige eller livstruende, og flere patienter med blastkrise døde med en kompleks anamnese af pleuraeksudat, kongestivt hjerteinsufficiens og nyresvigt.
English: Dermatofibrosarcoma protuberans (DFSP).
Danish: - Dermatofibrosarkom protuberans (DFSP).
English: The patients were distributed in three main categories: haematological failure (29%), cytogenetic failure (35%), or intolerance to interferon (36%).
Danish: Patienterne blev fordelt i 3 hovedkategorier: Manglende hæmatologisk effekt (29 %), manglende cytogenetisk effekt (35 %) eller interferonintolerans (36 %).
English: Middlesex, HA1 4HF United Kingdom
Danish: Middlesex, HA1 4HF Storbritannien eller
English: At 84 months the estimated overall survival is 86.4% (83, 90) vs. 83.3% (80, 87) in the randomised Imatinib and the IFN+Ara-C groups, respectively (p=0.073, log-rank test).
Danish: Ved 84 måneder var den estimerede samlede overlevelse 86,4 % (83, 90) vs. 83,3 % (80, 87) i henholdsvis de randomiserede Imatinib- og IFN+Ara-C-grupper (p=0,073, log-rank test).
English: This will help protect you from stomach problems when taking Imatinib Accord.
Danish: Dette vil hjælpe med at beskytte dig mod maveproblemer, når du tager Imatinib Accord.
English: Dosing for children and adolescents should be on the basis of body surface area (mg/m2).
Danish: Dosering hos og unge børn bør baseres på legemsoverflade (mg/m2).
English: Imatinib pharmacokinetics have not been specifically studied in elderly.
Danish: Ældre: Imatinibs farmakokinetik er ikke specifikt undersøgt hos ældre.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP Blister
English: When assuming conservatively that patients with missing data were non-responders, CHR was observed in 20/23 (87%) patients, CCyR in 9/23 (39.1%) patients, and MR in 11/23 (47.8%) patients, respectively.
Danish: Ved en konservativ antagelse af at patienter med manglende data er ikkerespondenter, blev CHR observeret hos 20/23 (87 %), CCyR hos 9/23 (39,1 %) og MR hos 11/23 (47,8 %) af patienterne.
English: • Do not use any pack that is damaged or shows signs of tampering.
Danish: • Pakningen må ikke anvendes, hvis den er beskadiget, eller der er tegn på, at pakningen har været åbnet.
English: - If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Danish: Graviditet, amning og frugtbarhed - Hvis du er gravid eller ammer, har mistanke om, at du er gravid, eller planlægger at blive gravid, skal du spørge din læge til råds, før du tager dette lægemiddel.
English: Imatinib Accord is a medicine containing an active substance called imatinib.
Danish: Imatinib Accord er et lægemiddel, der indeholder et aktivt stof kaldet imatinib.
English: Table 2 Response in newly diagnosed CML Study (84-month data)
Danish: Tabel 2 Respons i undersøgelsen vedrørende nydiagnosticeret CML (84 måneders data) Imatinib
English: A further 6DFSP patients treated with imatinib were reported in 5 published case reports, their ages ranging from 18 months to 49 years.
Danish: Yderligere seks patienter, behandlet med imatinib, er blevet beskrevet i 5 publicerede kasuistikker, alderen varierede fra 18 måneder til 49 år.
English: Imatinib Accord is indicated for the treatment of
Danish: Imatinib Accord er indiceret til behandling af
English: Similar results were observed in patients with malignant gliomas treated with imatinib while taking enzyme-inducing anti-epileptic drugs (EIAEDs) such as carbamazepine, oxcarbazepine and phenytoin.
Danish: Lignende resultater blev observeret hos patienter med maligne gliomer behandlet med Imatinib samtidig med indtagelse af enzyminducerende antiepileptiske lægemidler (EIAEDs) som carbamazepin, oxcarbazepin og phenytoin.
English: The effect of Imatinib treatment on survival in chronic phase, newly diagnosed CML has been further examined in a retrospective analysis of the above reported Imatinib data with the primary data from another Phase III study using IFN+Ara-C (n=325) in an identical regimen.
Danish: Effekten af Imatinib-behandling på overlevelse i kronisk fase, nyligt diagnostiseret CML er blevet yderligere undersøgt i en retrospektiv analyse af ovenstående rapporterede Imatinib-data med primærdata fra et andet fase III-studie, hvor IFN+Ara-C (n=325) blev anvendt i et tilsvarende behandlingsregime.
English: In GIST patients (study B2222), 6.8% of grade 3 or 4 ALT (alanine aminotransferase) elevations and 4.8% of grade 3 or 4 AST (aspartate aminotransferase) elevations were observed.
Danish: Der blev hos GIST patienter (studie B2222) observeret stigning i grad 3 eller 4 ALAT (alaninaminotransferase) hos 6,8% og stigning i grad 3 eller 4 ASAT (aspartataminotransferase) hos 4,8%.
English: Studies on patients receiving Imatinib Accord and its effect on fertility and gametogenesis have not been performed.
Danish: Der er ikke udført studier med patienter, der fik Imatinib Accord, og dets virkning på fertilitet og gametogenese.
English: Because of known increased risks of bleeding in conjunction with the use of imatinib (e.g. haemorrhage), patients who require anticoagulation should receive low-molecular-weight or standard heparin, instead of coumarin derivatives such as warfarin.
Danish: På grund af kendt øget risiko for blødning i forbindelse med brug af Imatinib (f.eks. hæmoragi) bør patienter med behov for antikoagulantia have heparin med lav molekylevægt eller standardheparin i stedet for coumarinderivater som warfarin.
English: Imatinib Accord is also a treatment for children and adolescents with CML.
Danish: Imatinib Accord bruges også til behandling af børn og unge med CML.
English: Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Danish: Du kan finde yderligere oplysninger om dette lægemiddel på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu
English: Pharmacokinetics in children and adolescents
Danish: Farmakokinetik hos børn og unge
English: If you are being treated for CML
Danish: Hvis du er i behandling for CML
English: A total of 71 (12.8%) and 85 (15.4%) patients died in the Imatinib and IFN+Ara-C groups, respectively.
Danish: I alt døde 71 (12,8 %) og 85 (15,4 %) patienter i henholdsvis Imatinib- og IFN+Ara-C-grupperne.
English: OTHER SPECIAL WARNING(S), IF NECESSARY Use only as directed by a doctor.
Danish: EVENTUELLE ANDRE SÆRLIGE ADVARSLER Anvendes som foreskrevet af lægen.
English: Hypromellose 6 cps (E464) Microcrystalline cellulose pH 102 Crospovidone
Danish: Hypromellose 6 cps (E464) Mikrokrystallinsk cellulose ph 102 Crospovidon
English: If laboratory or clinical findings associated with TMA occur in a patient receiving Imatinib Accord, treatment should be discontinued and thorough evaluation for TMA, including ADAMTS13 activity and anti-ADAMTS13antibody determination, should be completed.
Danish: Hvis laboratorie- eller kliniske fund associeret med TMA forekommer hos en patient, som er i behandling med Imatinib Accord, skal behandlingen seponeres og der skal foretages en grundig undersøgelse for TMA, inklusiv ADAMTS13-aktivitet og anti-ADAMTS13-antistofbestemmelse.
English: Major cytogenetic response, haematological response, molecular response (evaluation of minimal residual disease), time to accelerated phase or blast crisis and survival are main secondary endpoints.
Danish: Større cytogenetisk respons, hæmatologisk respons, molekulær respons (evaluering af minimal tilbageværende sygdom), tid til accellereret fase eller blastkrise samt overlevelse er de sekundære hovedeffektmål.
English: In adults the dose should be reduced from 400 to 300 mg or from 600 to 400 mg, or from 800 mg to 600 mg, and in children and adolescents from 340 to 260 mg/m2/day.
Danish: Hos voksne bør dosis reduceres fra 400 til 300 mg eller fra 600 til 400 mg, eller fra 800 mg til 600 mg, og hos børn og unge fra 340 til 260 mg/m2/dag.
English: • Unusual hair loss or thinning.
Danish: • Usædvanligt hårtab eller udtyndning af håret.
English: Myelodysplastic/myeloproliferative diseases (MDS/MPD).
Danish: - Myelodysplastiske/myeloproliferative sygdomme (MDS/MDP).
English: In the Imatinib arm, patients were treated with 400 mg daily.
Danish: I Imatinib-armen blev patienterne behandlet med 400 mg daglig.
English: In CML, cytopenias, particularly neutropenia and thrombocytopenia, have been a consistent finding in all studies, with the suggestion of a higher frequency at high doses ≥ 750 mg (phase I study).
Danish: Cytopeni hos CML-patienter, særligt neutropeni og trombocytopeni, har været gennemgående fund i alle undersøgelser med tegn på større hyppighed ved doser 750 mg (fase I undersøgelse).
English: This time-to-event endpoint is strongly affected by the high crossover rate from IFN+Ara-C to Imatinib.
Danish: Dette tid-til-hændelse effektmål er stærkt påvirket af det høje antal skift fra IFN+Ara-C-armen til Imatinib-armen.
English: Imatinib Accord inhibits the growth of these cells.
Danish: Imatinib Accord hæmmer væksten af disse celler.
English: Pharmacotherapeutic group: antineoplastic agents, protein kinase inhibitor, ATC code: L01XE01
Danish: Farmakoterapeutisk klassifikation: antineoplastiske stoffer, protein-tyrosinkinasehæmmer, ATC-kode: L01XE01
English: Ileus/intestinal obstruction*, gastrointestinal perforation*, diverticulitis*, gastric antral vascular ectasia (GAVE)* Hepatobiliary disorders Common
Danish: Ileus/intestinal obstruktion*, gastrointestinal perforation*, diverticulitis*, gastric antral vascular ectasia (GAVE)*
English: In clinical trials, there was an increased incidence of these events in elderly and those with a prior history of cardiac disease.
Danish: Der er i kliniske undersøgelser set øget incidens af disse hændelser hos ældre og hos patienter med hjertesygdom i anamnesen.
English: With 7 years follow-up, there were 93 (16.8%) progression events in the Imatinib arm: 37 (6.7%) involving progression to accelerated phase/blast crisis, 31 (5.6%) loss of MCyR, 15 (2.7%) loss of CHR or increase in WBC, and 10 (1.8%) CML unrelated deaths.
Danish: Ved 7-års opfølgning var der 93 (16,8 %) progressionshændelser i Imatinib -armen: 37 (6,7 %) omhandlede progression til accelereret fase/blastkrise, 31 (5,6 %) tab af MCyR, 15 (2,7 %) tab af CHR eller stigning i WBC, og 10 (1,8 %) dødsfald ikke relateret til CML.
English: You may become more sensitive to the sun while taking Imatinib Accord.
Danish: Du kan blive mere følsom overfor sollys, når du tager Imatinib Accord.
English: Patients with cardiac disease, risk factors for cardiac failure or history of renal failure should be monitored carefully, and any patient with signs or symptoms consistent with cardiac failure or renal failure should be evaluated and treated.
Danish: Patienter med hjertesygdom, risikofaktorer for hjerteinsufficiens eller nyreinsufficiens i anamnesen skal monitoreres omhyggeligt, og alle patienter, som har symptomer forenelige med hjerte- eller nyreinsufficiens, bør undersøges og behandles.
English: 6 doses)iii: days 2, 3, 16, and 17
Danish: 6 doser)iii: dag 2, 3, 16, og 17
English: Total bilirubin: > 3-10 ULN AST: any ULN = upper limit of normal for the institution AST = aspartate aminotransferase
Danish: Total bilirubin: >3-10 ULN ASAT: alt ULN = laboratoriets øvre normalgrænse ASAT = aspartataminotransferase
English: The primary efficacy variable of the study was the rate of major cytogenetic response (complete plus partial response, 0 to 35% Ph+ metaphases in the bone marrow).
Danish: Undersøgelsens primære effektvariabel var graden af det cytogenetiske hovedrespons (fuldstændigt plus partielt respons, 0-35 % Ph+-metafaser i knoglemarven).
English: doses)iii: days 2 and 3
Danish: doses)iii: dag 2 og 3
English: Ara-C: cytosine arabinoside; CP: cyclophosphamide; DEX: dexamethasone; MTX: methotrexate; 6-MP: 6-mercaptopurine VM26: Teniposide; VCR: vincristine; IDA: idarubicine; i.v.
Danish: Ara-C: cytosin arabinosid; CP: cyclophosphamid; DEX: dexamethason; MTX: methotrexat; 6MP: 6-mercaptopurin; VM26: teniposid; VCR: vinkristin; IDA: idarubicin; i.v.
English: Tell your doctor straight away if you get any of the following
Danish: Kontakt din læge med det samme, hvis du oplever nogle af de følgende bivirkninger
English: This phase III study in adult patients compared treatment with either single-agent Imatinib or a combination of interferon-alpha (IFN) plus cytarabine (Ara-C).
Danish: Denne fase III undersøgelse hos voksne patienter sammenlignede enkeltstof-behandling med Imatinib med behandling med en kombination af interferon-alfa (IFN) og cytarabin (Ara-C).
English: In vitro imatinib inhibits the cytochrome P450 isoenzyme CYP2D6 activity at concentrations similar to those that affect CYP3A4 activity.
Danish: In vitro hæmmer Imatinib cytochrom P450 isoenzym CYP2D6-aktivitet ved koncentrationer svarende til dem, der påvirker CYP3A4-aktivitet.
English: Total bilirubin: > 1.5-3.0 ULN AST: any
Danish: Total bilirubin: >1,5-3,0 ULN ASAT: alt
English: The paediatric patient received 400 mg/m2/daily, subsequently increased to 520 mg/m2/daily.
Danish: Den pædiatriske patient fik 400 mg/m2/daglig, hvilket efterfølgende blev øget til 520 mg/m2/daglig.
English: Packs containing 10, 30, or 90 film-coated tablets.
Danish: Pakninger indeholdende 10, 30 eller 90 filmovertrukne tabletter.
English: Using this approach, the estimated cumulative response rates for first-line treatment with Imatinib improved from 12 months of therapy to 84 months of therapy as follows: CHR from 96.4% to 98.4% and CCyR from 69.5% to 87.2%, respectively.
Danish: Ved brug af denne metode øgedes den estimerede kumulative responsfrekvens for førstevalgsbehandling med Imatinib fra 12 måneders behandling til 84 måneders behandling som følgende: CHR fra 96,4 % til 98,4 % og CCyR fra 69,5 % til 87,2 %).
English: Chronic myeloid leukaemia (CML).
Danish: Kronisk myeloid leukæmi (CML).