FrancophonIA/ELRC3.0 huggingface dataset:
English: For more information about treatment with Bridion, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Bridion preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: The CHMP decided that Bridion's benefits are greater than its risks and recommended that it be given marketing authorisation.
Slovenian: CHMP je zaključil, da so koristi zdravila Bridion večje od z njim povezanih tveganj, in priporočil, da se zanj izda dovoljenje za promet.
English: A risk management plan has been developed to ensure that Bridion is used as safely as possible.
Slovenian: Za zagotovitev čim varnejše uporabe zdravila Bridion je bil pripravljen načrt obvladovanja tveganj.
English: What benefit has Bridion shown during the studies?
Slovenian: Kakšne koristi je zdravilo Bridion izkazalo med študijami?
English: What is the risk associated with Bridion?
Slovenian: Kakšna tveganja so povezana z zdravilom Bridion?
English: In all of the studies, the main measure of effectiveness was how long it took for the muscles to recover.
Slovenian: Glavno merilo učinkovitosti v vseh študijah je bil čas, ki je bil potreben, da so si mišice opomogle.
English: Bridion is a solution for injection that contains the active substance sugammadex (100 mg/ml).
Slovenian: Bridion je raztopina za injiciranje, ki vsebuje zdravilno učinkovino sugamadeks (100 mg/ml).
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Bridion.
Slovenian: Pojasnjuje, kako je Odbor za zdravila za uporabo v humani medicini (CHMP) ocenil to zdravilo, na podlagi česar je oblikoval mnenje za izdajo dovoljenja za promet z njim in priporočila glede pogojev njegove uporabe.
English: Bridion can only be given by or under the supervision of an anaesthetist (a doctor specialised in anaesthesia).
Slovenian: Zdravilo Bridion se lahko daje le pod nadzorom anestezista (zdravnika, ki je specializiran za anestezijo).
English: In contrast, muscle relaxation recovered spontaneously after 7.1 minutes.
Slovenian: V nasprotju s tem so si bolniki spontano opomogli po 7,1 minute.
English: This means that it attaches to the muscle relaxants rocuronium and vecuronium forming a ‘complex' that inactivates the muscle relaxants and stops them having an effect.
Slovenian: To pomeni, da se veže na mišična relaksanta rokuronij in vekuronij ter tako tvori „kompleks“, ki inaktivira mišične relaksante in jim prepreči, da bi učinkovali še naprej.
English: The most common side effects with Bridion (seen in between 1 and 10 patients in 100) are cough, airway problems due to the anaesthesia wearing off, reduced blood pressure and other complications such as changes in heart rate.
Slovenian: Najpogostejši neželeni učinki zdravila Bridion (opaženi pri 1 do 10 bolnikov od 100) so kašelj, težave z dihali zaradi pojenjanja učinkov anestezije), nižji krvni tlak ali drugi zapleti, kot so spremembe srčnega utripa.
English: In children and adolescents from two to 17 years of age, the recommended dose is 2 mg/kg body weight.
Slovenian: Priporočeni odmerek pri otrocih in mladostnikih, starih od 2 do 17 let, je 2 mg/kg telesne mase.
English: It is given as a single intravenous ‘bolus' injection (given into a vein all at once).
Slovenian: Zdravilo se daje v obliki ene same intravenske „bolusne“ injekcije (injekcije, ki se cela naenkrat vbrizga v veno).
English: Bridion has been studied in four main studies in a total of 579 adults undergoing surgery using muscle relaxants.
Slovenian: Zdravilo Bridion so raziskovali v štirih glavnih študijah pri skupno 579 odraslih, pri katerih je bil opravljen kirurški poseg, pri katerem so bili uporabljeni mišični relaksanti.
English: Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Bridion, including the appropriate precautions to be followed by healthcare professionals and patients.
Slovenian: V skladu z njim so bile v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo vključene informacije o varnosti, vključno s previdnostnimi ukrepi, ki jih morajo upoštevati zdravstveni delavci in bolniki.
English: Muscle relaxants are medicines used during some types of operation to make the muscles relax, including the muscles that help the patient to breathe.
Slovenian: Mišični relaksanti so zdravila, ki se uporabljajo pri nekaterih vrstah operacij za sprostitev mišic, vključno s tistimi, ki bolniku omogočajo dihanje.
English: Bridion can be used in adults who have received rocuronium and vecuronium, and in children and adolescents who have received rocuronium.
Slovenian: Zdravilo Bridion se lahko uporablja pri odraslih, ki so prejeli rokuronij ali vekuronij, in pri otrocih ter mladostnikih, ki so prejeli rokuronij.
English: Bridion must not be used in people who are hypersensitive (allergic) to sugammadex or any of the other ingredients.
Slovenian: Zdravila ne smejo uporabljati osebe, ki so preobčutljive za (alergične na) sugamadeks ali katero koli drugo sestavino zdravila.
English: For the full list of all side effects reported with Bridion, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Bridion, glejte navodilo za uporabo.
English: This was compared with spontaneous recovery after muscle relaxation using succinylcholine (another muscle relaxant).
Slovenian: To so primerjali s spontanim okrevanjem po relaksaciji mišic, sproženi s sukcinilholinom (drugo vrsto mišičnega relaksanta).
English: Why has Bridion been approved?
Slovenian: Zakaj je bilo zdravilo Bridion odobreno?
English: When used for rapid recovery, patients receiving 16 mg/kg Bridion recovered after 4.2 minutes.
Slovenian: Kadar se zdravilo uporablja za hitro okrevanje, so si bolniki, ki so prejeli 16 mg/kg zdravila Bridion, opomogli po 4,2 minute.
English: As a result, the effect of blockade of the muscles due to rocuronium and vecuronium on the muscles is reversed, and the muscles begin to work normally again, including the muscles that help the patient to breathe.
Slovenian: Posledično učinek blokade mišic zaradi učinkovanja rokuronija in vekuronija na mišice popusti, tako da začnejo te zopet delovati normalno, kar vključuje tudi tiste, ki bolniku omogočajo dihanje.
English: The active substance in Bridion, sugammadex, is a ‘selective relaxant binding agent'.
Slovenian: Zdravilna učinkovina zdravila Bridion, sugamadeks, je „selektiven vezalec mišičnih relaksantov“.
English: After moderate muscle relaxation, the average time for recovery was between 1.4 and 2.1 minutes for 2 mg/kg Bridion, compared with 17.6 to 18.9 minutes for neostigmine.
Slovenian: Po zmerni sprostitvi mišic je povprečen čas, potreben za okrevanje, znašal od 1,4 do 2,1 minute pri odmerku 2 mg/kg zdravila Bridion v primerjavi z od 17,6 do 18,9 minute pri uporabi neostigmina.
English: Bridion is not recommended for use in children and adolescents for recovery after vecuronium, or for rapid recovery after any muscle relaxant.
Slovenian: Uporaba zdravila Bridion pri otrocih in mladostnikih ni priporočena za okrevanje po uporabi vekuronija ali za hitro okrevanje po uporabi katerega koli mišičnega relaksanta.
English: The standard dose of Bridion is between 2 and 4 mg per kilogram body weight, depending on how much the muscle relaxant is affecting the muscles.
Slovenian: Običajni odmerek zdravila Bridion znaša od 2 do 4 mg na kilogram telesne mase, odvisno od jakosti učinka relaksanta na mišice.
English: Muscle relaxants make it easier for the surgeon to do the operation.
Slovenian: Kirurg s pomočjo mišičnih relaksantov lažje izvede kirurški poseg.
English: Bridion is used to speed up the recovery from the muscle relaxant, usually at the end of the operation.
Slovenian: Zdravilo Bridion se uporablja za pospeševanje okrevanja po uporabi mišičnih relaksantov, po navadi ob koncu kirurškega posega.
English: Bridion is used to reverse the effect of the muscle relaxants rocuronium and vecuronium.
Slovenian: Zdravilo Bridion se uporablja za odpravljanje učinkov mišičnih relaksantov rokuronija in vekuronija.
English: The effect of Bridion seen in adults was similar in adolescents and children aged over two years.
Slovenian: Pri mladostnikih in otrocih, starejših od dveh let, je bil učinek zdravila Bridion podoben tistemu, opaženemu pri odraslih.
English: The fourth study, involving 115 patients, looked at the effectiveness of 16 mg/kg Bridion in producing rapid reversal of the muscle relaxation using rocuronium.
Slovenian: V četrti študiji, v katero je bilo vključenih 115 bolnikov, so opazovali učinkovitost odmerka 16 mg/kg zdravila Bridion pri hitrem odpravljanju mišične sprostitve, sprožene z uporabo rokuronija.
English: After deep muscle relaxation, recovery took an average of around 3.0 minutes with 4 mg/kg Bridion, compared with around 49.5 minutes for neostigmine.
Slovenian: Po globoki sprostitvi mišic so bile za okrevanje potrebne približno 3,0 minute z odmerkom 4 mg/kg zdravila Bridion v primerjavi z 49,5 minute pri uporabi neostigmina.
English: Two of the studies, involving a total of 282 patients, looked at the effectiveness of 2 mg/kg Bridion in reversing moderate relaxation of the muscles due to rocuronium or vecuronium.
Slovenian: V dveh študijah, ki sta vključevali skupaj 282 bolnikov, so proučevali učinkovitost odmerka v višini 2 mg/kg zdravila Bridion pri odpravljanju zmerne sprostitve mišic zaradi uporabe rokuronija ali vekuronija.
English: Bridion was compared with neostigmine (another medicine used to stop the effect of muscle relaxants) given after rocuronium or vecuronium in the first study and after cis-atracurium (another muscle relaxant) in the second.
Slovenian: Zdravilo Bridion so primerjali z neostigminom (drugim zdravilom za odpravljanje učinkov mišičnih relaksantov), ki so ga v prvi študiji bolnikom dali za rokuronijem in vekuronijem, v drugi študiji pa za cisatrakurijem (drugo vrsto mišičnega relaksanta).
English: What is Bridion used for?
Slovenian: Za kaj se zdravilo Bridion uporablja?
English: How does Bridion work?
Slovenian: Kako zdravilo Bridion deluje?
English: How has Bridion been studied?
Slovenian: Kako je bilo zdravilo Bridion raziskano?
English: What is Bridion?
Slovenian: Kaj je zdravilo Bridion?
English: Bridion was more effective than neostigmine in reducing the time it took for the muscles to recover, after both moderate and deep muscle relaxation using rocuronium or vecuronium.
Slovenian: Zdravilo Bridion je bilo pri skrajšanju časa, ki je potreben, da si mišice opomorejo po zmerni in globoki relaksaciji mišic, ki so jo dosegli z rokuronijem ali vekuronijem, učinkovitejše od neostigmina.
English: How is Bridion used?
Slovenian: Kako se zdravilo Bridion uporablja?
English: The third study compared the effectiveness of 4 mg/kg Bridion with that of neostigmine after deep relaxation of the muscles using rocuronium or vecuronium in 182 patients.
Slovenian: V tretji študiji so pri 182 bolnikih učinkovitost odmerka 4 mg/kg zdravila Bridion primerjali z učinkovitostjo neostigmina po globoki relaksaciji mišic, doseženi z uporabo rokuronija ali vekuronija.
English: An additional study looked at the effectiveness of Bridion given after rocuronium in 90 children and adolescents.
Slovenian: V dodatni študiji so pri 90 otrocih in mladostnikih primerjali učinkovitost zdravila Bridion, ki so ga dali za rokuronijem.
English: A dose of 16 mg/kg can be used if rapid recovery from muscle relaxation is needed.
Slovenian: Če je treba mišice hitro vrniti iz sproščenega v prvotno stanje, se lahko uporabi odmerek 16 mg/kg.
English: Further information on Segluromet can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Slovenian: Več informacij o zdravilu Segluromet je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: The dose is one tablet twice a day with food.
Slovenian: Odmerek je ena tableta, ki se jemlje dvakrat na dan s hrano.
English: Segluromet is available as tablets in 4 strengths of ertugliflozin and metformin (2.5 mg/850 mg, 2.5 mg/1,000 mg, 7.5 mg/850 mg and 7.5 mg/1,000 mg).
Slovenian: Zdravilo Segluromet je na voljo v obliki tablet s štirimi jakostmi ertugliflozina in metformina (2,5 mg/850 mg, 2,5 mg/1 000 mg, 7,5 mg/850 mg in 7,5 mg/1 000 mg).
English: The European Medicines Agency concluded that Segluromet's benefits are greater than its risks and it can be authorised for use in the EU.
Slovenian: Evropska agencija za zdravila je zaključila, da so koristi zdravila Segluromet večje od z njim povezanih tveganj in da se lahko odobri za uporabo v EU.
English: What measures are being taken to ensure the safe and effective use of Segluromet?
Slovenian: Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Segluromet?
English: Segluromet (ertugliflozin / metformin hydrochloride)
Slovenian: Segluromet (ertugliflozin/metformin hidroklorid)
English: Other information about Segluromet
Slovenian: Druge informacije o zdravilu Segluromet
English: It must also not be used in patients with severe kidney problems or certain heart, circulatory, breathing or liver problems and in patients who drink alcohol to excess.
Slovenian: Prav tako se ne sme uporabljati pri bolnikih s hudimi okvarami ledvic ali nekaterimi težavami s srcem, obtočili, dihanjem ali jetri ter pri bolnikih, ki čezmerno pijejo alkohol.
English: Treatment will not be started if the kidney function is poor.
Slovenian: Zdravljenje se ne uvede, če je delovanje ledvic slabo.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Segluromet have been included in the summary of product characteristics and the package leaflet.
Slovenian: Priporočila in previdnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Segluromet upoštevati zdravstveni delavci in bolniki, so vključeni v povzetek glavnih značilnosti zdravila in navodilo za uporabo.
English: The most common side effects with Segluromet (which may affect more than 1 in 10 people) are fungal infections of the vagina and other infections of the female reproductive system and problems with the gut such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite.
Slovenian: Najpogostejši neželeni učinki zdravila Segluromet (ki se lahko pojavijo pri več kot 1 bolniku od 10) so glivične okužbe nožnice in druge okužbe ženskih spolovil ter težave s prebavili, kot so slabost, bruhanje, driska, bolečine v trebuhu in izguba teka.
English: The studies looked mainly at effects on levels of HbA1c (a measure of blood glucose) after 6 months or one year of treatment.
Slovenian: V študijah so proučevali predvsem učinke na vrednost HbA1c (merilo za glukozo v krvi) po šestih mesecih ali enem letu zdravljenja.
English: What benefits of Segluromet have been shown in studies?
Slovenian: Kakšne koristi zdravila Segluromet so se pokazale v študijah?
English: As for all medicines, data on the use of Segluromet is continuously monitored.
Slovenian: Tako kot za vsako zdravilo se tudi podatki o uporabi zdravila Segluromet stalno spremljajo.
English: Why is Segluromet authorised in the EU?
Slovenian: Zakaj je bilo zdravilo Segluromet odobreno v EU?
English: An overview of Segluromet and why it is authorised in the EU
Slovenian: Pregled zdravila Segluromet in zakaj je odobreno v EU
English: For more information about using Segluromet, see the package leaflet or contact your doctor or pharmacist.
Slovenian: Za več informacij glede uporabe zdravila Segluromet glejte navodilo za uporabo ali se posvetujte z zdravnikom ali farmacevtom.
English: Side effects reported with Segluromet are carefully evaluated and any necessary action taken to protect patients.
Slovenian: Neželeni učinki, o katerih so poročali pri zdravilu Segluromet, se skrbno ovrednotijo in po potrebi se sprejmejo ukrepi za zaščito bolnikov.
English: A lower dose of ertugliflozin 5 mg was less effective.
Slovenian: Manjši, 5-miligramski odmerek ertugliflozina je bil manj učinkovit;
English: At the start of the studies, patients' HbA1c was above 7 percentage points.
Slovenian: Na začetku študij so bile vrednosti HbA1c pri bolnikih višje od 7 odstotnih točk.
English: What is Segluromet and what is it used for?
Slovenian: Kaj je zdravilo Segluromet in za kaj se uporablja?
English: What are the risks associated with Segluromet?
Slovenian: Kakšna tveganja so povezana z zdravilom Segluromet?
English: • patients who are already taking ertugliflozin and metformin as separate tablets.
Slovenian: • bolnikih, ki ertugliflozin in metformin že jemljejo v obliki ločenih tablet.
English: • patients whose glucose levels are not well controlled with the highest dose of metformin they can take
Slovenian: • bolnikih, pri katerih vrednost glukoze ni dobro urejena z največjim odmerkom metformina, ki ga lahko jemljejo;
English: It is used together with diet and exercise in the following patients:
Slovenian: Uporablja se kot dodatek k dieti in telesni vadbi, in sicer pri:
English: Segluromet is a medicine used to control blood glucose (sugar) levels in adults with type 2 diabetes.
Slovenian: Segluromet je zdravilo, ki se uporablja za uravnavanje ravni glukoze (sladkorja) v krvi pri odraslih s sladkorno boleznijo tipa 2.
English: Segluromet must not be used in patients with uncontrolled diabetes with severe symptoms that lead to high acid levels in the blood.
Slovenian: Zdravilo Segluromet se ne sme uporabljati pri bolnikih z neurejeno sladkorno boleznijo s hudimi simptomi, ki povzročajo visoko raven kisline v krvi.
English: Segluromet can also help some patients lose weight.
Slovenian: Zdravilo Segluromet lahko nekaterim bolnikom pomaga tudi zmanjšati telesno maso.
English: It does this by blocking a protein in the kidneys (called SGLT2) that normally takes glucose back into the blood from the kidneys.
Slovenian: To doseže z zaviranjem beljakovine v ledvicah (imenovane SGLT2), ki normalno privzema glukozo iz ledvic v kri.
English: Four main studies in over 3,600 patients with type 2 diabetes have shown that adding ertugliflozin to metformin helps lower glucose levels when metformin is not working well enough.
Slovenian: Štiri glavne študije pri več kot 3 600 bolnikih s sladkorno boleznijo tipa 2 so pokazale, da dodajanje ertugliflozina metforminu pomaga zniževati vrednosti glukoze, kadar metformin ni dovolj učinkovit.
English: The strength of Segluromet tablet to use depends on how well the patient's glucose levels are controlled.
Slovenian: Katero jakost tablet zdravila Segluromet uporabiti, je odvisno od tega, kako dobro je pri bolniku uravnavana vrednost glukoze.
English: The doctor will check how well the patient's kidneys are working before treatment and once a year during treatment.
Slovenian: Zdravnik bo pred zdravljenjem in enkrat na leto med zdravljenjem preveril, kako dobro delujejo bolnikove ledvice.
English: Studies showed that Segluromet can help lower glucose levels in patients whose metformin treatment is not working well enough, including those taking another diabetes medicine in addition to metformin.
Slovenian: Študije so pokazale, da lahko zdravilo Segluromet pomaga znižati vrednost glukoze pri bolnikih, pri katerih zdravljenje z metforminom ni dovolj učinkovito, vključno s tistimi, ki poleg metformina jemljejo še katero drugo zdravilo za zdravljenje sladkorne bolezni.
English: Finally, in addition to lowering glucose levels, studies showed that adding ertugliflozin to metformin helped patients reduce bodyweight.
Slovenian: Poleg zniževanja vrednosti glukoze so študije pokazale tudi, da dodatek ertugliflozina metforminu bolnikom pomaga zmanjšati telesno maso.
English: Segluromet contains two active substances, ertugliflozin and metformin.
Slovenian: Zdravilo Segluromet vsebuje dve zdravilni učinkovini, ertugliflozin in metformin.
English: In this study, HbA1c levels fell by 0.6 points with ertugliflozin and 0.7 points with glimepiride.
Slovenian: V tej študiji so vrednosti HbA1c pri ertugliflozinu padle za 0,6 odstotne točke, pri glimepiridu pa za 0,7 odstotne točke.
English: Metformin, on the other hand, works mainly by blocking glucose production in the body and by reducing the absorption of glucose in the gut.
Slovenian: Metformin pa deluje predvsem tako, da zavira nastajanje glukoze v telesu in zmanjšuje absorpcijo glukoze iz črevesja.
English: • A second study found that adding ertugliflozin to a combination of sitagliptin (another diabetes medicine) and metformin was more effective than placebo.
Slovenian: • druga študija je pokazala, da je dodatek ertugliflozina kombinaciji sitagliptina (drugega zdravila za zdravljenje sladkorne bolezni) in metformina učinkovitejši od placeba.
English: Ertugliflozin helps to lower blood glucose by making the patient pass out glucose in the urine.
Slovenian: Ertugliflozin pomaga zniževati vrednost glukoze v krvi tako, da pripomore k temu, da se glukoza iz bolnikovega telesa izloča z urinom.
English: Steglatro is not as effective in patients with moderate kidney impairment and should therefore not be started in such patients.
Slovenian: Pri bolnikih z zmerno okvaro ledvic zdravilo Segluromet ni tako učinkovito in se zato ne sme uvesti.
English: • patients on the highest dose of metformin they can take who are also taking another diabetes medicine
Slovenian: • bolnikih z največjim odmerkom metformina, ki ga lahko jemljejo, ki poleg tega jemljejo še katero drugo zdravilo za zdravljenje sladkorne bolezni;
English: Segluromet can only be obtained with a prescription.
Slovenian: Predpisovanje in izdaja zdravila Segluromet je le na recept.
English: • A third study found that a combination of ertugliflozin at a 15 mg dose with metformin was about as effective as a combination of metformin with another diabetes medicine, glimepiride.
Slovenian: • tretja študija je pokazala, da je bila kombinacija ertugliflozina v odmerku 15 mg in metformina približno enako učinkovita kot kombinacija metformina s še enim zdravilom za zdravljenje sladkorne bolezni, glimepiridom.
English: • The first study found that in patients taking a combination of ertugliflozin and metformin, HbA1c levels fell by around 0.8 points, compared with reductions of 0.03 when placebo (a dummy treatment) was added to metformin.
Slovenian: • prva študija je pokazala, da se je pri bolnikih, ki so jemali kombinacijo ertugliflozina in metformina, vrednost HbA1c zmanjšala za približno 0,8 odstotne točke, v primerjavi z zmanjšanjem za 0,03 odstotne točke, če je bil metforminu dodan placebo (zdravilo brez zdravilne učinkovine);
English: How is Segluromet used?
Slovenian: Kako se zdravilo Segluromet uporablja?
English: • The fourth study found that, in patients taking metformin, adding ertugliflozin was as effective as adding sitagliptin with HbA1c levels falling by around 1 point with both treatments.
Slovenian: • četrta študija je pokazala, da je bil pri bolnikih, ki so jemali metformin, dodatek ertugliflozina enako učinkovit kot dodatek sitagliptina, pri čemer so vrednosti HbA1c pri obeh načinih zdravljenja padle za približno eno odstotno točko.
English: For the full list of side effects of Segluromet, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Segluromet, glejte navodilo za uporabo.
English: HbA1c levels fell by between 0.8 and 0.9 percentage points when ertugliflozin was added, compared with a fall of 0.1 with placebo
Slovenian: Vrednosti HbA1c so pri dodatku ertugliflozina padle za 0,8 do 0,9 odstotne točke, pri jemanju placeba pa za 0,1 odstotne točke;
English: The two active substances in Segluromet, ertugliflozin and metformin, work in different ways to lower glucose levels.
Slovenian: Zdravilni učinkovini v zdravilu Segluromet, ertugliflozin in metformin, vrednost glukoze v krvi znižujeta različno.
English: HbA1c levels fell by a further 0.5 points when both medicines were added to metformin.
Slovenian: Če sta bili metforminu dodani obe zdravili, je raven HbA1c padla za nadaljnje 0,5 odstotne točke.