FrancophonIA/ELRC3.0 huggingface dataset:
English: Aseptically transfer the contents of the reconstituted vial(s) into an intravenous bag (or bottle) containing either 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion obtaining an anidulafungin concentration of 0.77 mg/mL.
Croatian: Na aseptički način prenesite sadržaj rekonstituirane otopine iz bočice(a) u intravensku vrećicu (ili bocu) koja sadrži ili otopinu natrijevog klorida od 9 mg/ml (0,9%) za infuziju ili otopinu glukoze od 50 mg/ml (5%) za infuziju, tako da se dobije koncentracija anidulafungina od 0,77 mg/ml.
English: White to off-white solid.
Croatian: Bijela do gotovo bijela kruta tvar.
English: Non-neutropenic (ANC, cells/mm
Croatian: Bez neutropenije (apsolutni broj neutrofila, stanice/mm
English: Anaphylacti c shock, anaphylactic reaction*
Croatian: Anafilaktičk a reakcija*
English: General pharmacokinetic characteristics
Croatian: Opća farmakokinetička svojstva
English: The effect of ECALTA in breast-feeding women is not known.
Croatian: Nije poznat učinak lijeka ECALTA u dojilja.
English: - if you are given anaesthetics during your treatment with ECALTA.for signs of an allergic reaction such as itching, wheezing, blotchy skin - for signs of an infusion-related reaction which could include a rash, hives, itching, redness, - for shortness of breath/breathing difficulties, dizziness or lightheadedness
Croatian: Liječnik Vas može odlučiti pratiti - radi pažljivijeg nadziranja funkcije jetre ako Vam se tijekom liječenja pojave tegobe s jetrom - ako za vrijeme liječenja lijekom ECALTA dobivate anestetike - zbog moguće pojave znakova alergijske reakcije kao što su svrbež, piskanje, pojava mrlja na koži - zbog moguće pojave znakova reakcije povezane s infuzijom što može uključivati osip,
English: How to use ECALTA
Croatian: Kako primjenjivati lijek ECALTA
English: ECALTA 100 mg powder for concentrate for solution for infusion anidulafungin
Croatian: ECALTA 100 mg prašak za koncentrat za otopinu za infuziju anidulafungin
English: In clinically stable patients, a switch to oral azole therapy was permitted after at least 5 to 10 days of treatment with anidulafungin.
Croatian: Kod klinički stabilnih bolesnika prebacivanje na peroralnu terapiju azolima bilo je dopušteno nakon najmanje 5 do 10 dana liječenja anidulafunginom.
English: ECALTA must be reconstituted with water for injections and subsequently diluted with ONLY sodium chloride 9 mg/mL (0.9%) solution for injection or 50 mg/mL (5%) glucose for infusion.
Croatian: ECALTA se mora pripremiti s vodom za injekciju i nakon toga razrijediti SAMO s otopinom natrijevog klorida od 9 mg/ml (0,9%) za infuziju ili otopinom glukoze od 50 mg/ml (5%) za infuziju.
English: Exacerbation of infusion-related reactions by co-administration of anaesthetics has been seen in a nonclinical (rat) study (see section 5.3).
Croatian: U nekliničkim ispitivanjima (na štakorima) opažena je egzacerbacija reakcija povezanih s infuzijom kod istovremene primjene anestetika (vidjeti dio 5.3).
English: Tel: +44 (0)1304 616161
Croatian: Pfizer Limited Tel: +44 (0)1304 616161
English: 60 mL 200 mL 260 mL 1.4 mL/ min
Croatian: 1,4 ml/min 90 min
English: Gammaglutamyltrans ferase increased
Croatian: Povišena gamaglutam iltransferaza
English: The reconstituted solution may be stored at up to 25°C for up to 24 hours.
Croatian: Rekonstituirana otopina može se čuvati na temperaturi do 25ºC najviše 24 sata.
English: Sodium hydroxide (for pH-adjustment) Hydrochloric acid (for pH-adjustment)
Croatian: 6.1 Popis pomoćnih tvari fruktoza manitol polisorbat 80 tartaratna kiselina natrijev hidroksid (za podešavanje pH) kloridna kiselina (za podešavanje pH)
English: Either 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion.
Croatian: Ili otopina natrijevog klorida od 9 mg/ml (0,9%) za infuziju ili otopina glukoze od 50 mg/ml (5%) za infuziju.
English: Coagulopathy
Croatian: Koagulopati ja
English: The contents of the vial must be reconstituted with water for injections and subsequently diluted with ONLY 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion.
Croatian: Sadržaj bočice mora se rekonstituirati s vodom za injekcije i nakon toga razrijediti SAMO s otopinom natrijevog klorida od 9 mg/ml (0,9%) za infuziju ili otopinom glukoze od 50 mg/ml (5%) za infuziju.
English: Contact your doctor immediately if you become pregnant while taking ECALTA.
Croatian: Ako zatrudnite tijekom uzimanja lijeka ECALTA, odmah se obratite svom liječniku.
English: Pfizer Luxembourg SARL filialas Lietuvoje
Croatian: Pfizer Luxembourg SARL filialas Lietuvoje Tel.
English: EXP {MM/YYYY}
Croatian: stanica/mm
English: Serious side effects - tell your doctor or another healthcare professional immediately should any of the following occur: - Convulsion (seizure) - Flushing - Rash, pruritis (itching) - Hot flush - Hives - Sudden contraction of the muscles around the airways resulting in wheezing or coughing - Difficulty of breathing
Croatian: - konvulzije (napadaji) - navale crvenila - osip, svrbež - navale vrućine - koprivnjača - iznenadno stezanje mišića oko dišnih puteva koje uzrokuje piskanje ili kašalj - poteškoće s disanjem
English: 30 mL 100 mL 130 mL 1.4 mL/ min
Croatian: 1,4 ml/min 180 min
English: Infusion solution
Croatian: Otopina za infuziju
English: Intra-abdominal Data presented for patients with a single baseline pathogen.
Croatian: d Podaci za bolesnike s jednim patogenom na početku ispitivanja.
English: 2 Week Follow-up e
Croatian: Kraj svih terapija e nakon 2 tjedna praćenja e nakon 6 tjedana praćenja
English: The solution should be inspected visually for particulate matter and discoloration prior to administration.
Croatian: Otopinu treba vizualno pregledati prije primjene da ne sadrži čestice i da nije promijenila boju.
English: Lot {number}
Croatian: Serija: {broj}
English: Pfizer România S.R.L Tel: +40 (0)21 207 28 00
Croatian: Tel: +40 (0)21 207 28 00
English: Powder for concentrate for solution for infusion
Croatian: 1 bočica prašak za koncentrat za otopinu za infuziju
English: Neutropenic (ANC, cells/mm At Other Endpoints End of All Therapy e
Croatian: S neutropenijom (apsolutni broj neutrofila, stanice/mm Ostali ishodi
English: The compatibility of reconstituted ECALTA with intravenous substances, additives, or medicines other than 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion has not been established.
Croatian: Osim s otopinom natrijevog klorida od 9 mg/ml (0,9%) za infuziju ili otopinom glukoze od 50 mg/ml (5%) za infuziju, nije ustanovljena kompatibilnost rekonstituiranog lijeka ECALTA s drugim intravenskim tvarima, aditivima ili lijekovima.
English: Hypokalaemia Hyperglycaemia
Croatian: Hiperglikemija
English: - If you get any side effects, talk to your doctor, or pharmacist or nurse.
Croatian: - Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika ili medicinsku sestru.
English: Mannitol
Croatian: Urtikarija
English: Vial label
Croatian: Naljepnica na bočici
English: Elderly
Croatian: ECALTA
English: Annex IV Conditions to the marketing authorisations
Croatian: Prilog IV. Uvjeti odobrenja za stavljanje u promet
English: From the date of notification of the Commission Decision
Croatian: Od datuma obavijesti o odluci Komisije
English: Within 4 years after Commission decision
Croatian: U roku od četiri godine nakon odluke Komisije
English: Within 3 months after Commission decision
Croatian: U roku od tri mjeseca nakon odluke Komisije
English: The RMP should reflect the following additional risk minimisation measures to address the important identified risk of medication errors resulting in overdose: - educational material(s) for healthcare professionals developed in accordance with the key elements agreed; - the agreed patient card.
Croatian: Plan upravljanja rizikom mora odražavati sljedeće dodatne mjere za smanjenje rizika kako bi se riješio važan utvrđeni rizik od medikacijskih pogrešaka koje rezultiraju predoziranjem: - edukacijske materijale za zdravstvene radnike izrađene u skladu s dogovorenim ključnim elementima; - dogovorenu karticu za bolesnika.
English: All methotrexate-containing products Each MAH should implement the agreed targeted follow-up questionnaires for all medication errors resulting in overdose.
Croatian: Svaki nositelj odobrenja za stavljanje lijeka u promet treba provesti dogovorene ciljane upitnike za praćenje svih medikacijskih pogrešaka koje su rezultirale predoziranjem.
English: The marketing authorisation holders shall complete the below conditions, within the stated timeframe, and competent authorities shall ensure that the following is fulfilled:
Croatian: Nositelji odobrenja za stavljanje u promet moraju ispuniti uvjete u nastavku u navedenom roku, a nadležna tijela moraju osigurati ispunjavanje sljedećih uvjeta:
English: Methotrexate-containing products for oral use with at least one indication requiring once weekly dosing Each MAH should operate a risk management system to be described in a risk management plan (RMP) which shall be submitted to the relevant Competent Authorities.
Croatian: Lijekovi koji sadrže metotreksat za peroralnu primjenu s najmanje jednom indikacijom za koju je potrebno doziranje jedanput tjedno Svaki nositelj odobrenja za stavljanje lijeka u promet treba primijeniti sustav upravljanja rizikom koji se mora opisati u planu upravljanja rizikom te se dostavlja relevantnim nadležnim tijelima.
English: MAHs should replace any bottle or tube used as immediate packaging by blisters.
Croatian: Za formulacije u tabletama potrebno je provesti i sljedeću mjeru: Nositelji odobrenja za stavljanje lijeka u promet trebaju bočicu ili epruvetu koje se koriste kao unutarnje pakiranje zamijeniti blisterima.
English: Then disconnect the syringe (with needle) from the device.
Croatian: Potom odvojite štrcaljku (s iglom) od nastavka.
English: First wash your hands!
Croatian: Najprije operite ruke!
English: · Risk Management plan (RMP)
Croatian: Plan upravljanja rizikom (RMP)
English: [units]
Croatian: [jedinice]
English: You must talk to your doctor if you do not feel better or if you feel worse.
Croatian: Obavijestite svog liječnika ako se ne osjećate bolje ili se osjećate lošije.
English: 8 Wash your hands with soap and water.
Croatian: Operite ruke sapunom i vodom.
English: (See instruction for use at the end of this leaflet)
Croatian: (Pogledajte upute za primjenu na kraju ove upute)
English: Treatment must be started under the supervision of your doctor.
Croatian: Liječenje mora započeti pod nadzorom liječnika.
English: This can be treated by your doctor.
Croatian: Ta stanja može liječiti Vaš liječnik.
English: Do not take a double dose to make up for any forgotten doses.
Croatian: Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljene doze.
English: The first dose is usually given to you under medical supervision, because of the possibility of an allergic reaction.
Croatian: Prva se doza obično daje pod liječničkim nadzorom, zbog mogućnosti alergijske reakcije.
English: · If needed, you may cover the injection site with a small bandage.
Croatian: ● Ako je potrebno, možete prekriti mjesto injiciranja malim flasterom.
English: Date of the last renewal: 16 July 2007
Croatian: Datum posljednje obnove odobrenja: 16. srpnja 2007.
English: Children will start by following the same guidelines.
Croatian: Liječenje u djece započinje se po istim smjernicama.
English: Rare Very rare
Croatian: Vrlo rijetko
English: The recommended treatment duration is 6 weeks.
Croatian: Preporučeno trajanje liječenja je 6 tjedana.
English: Depending on your individual situation a blood transfusion may be preferable.
Croatian: Ovisno o Vašoj individualnoj situaciji, transfuzija krvi može biti primjerenija.
English: Nevertheless, the recommended dosing schedule should be followed as the individual response cannot be predicted.
Croatian: No, ipak treba se držati preporučene sheme doziranja, jer nije moguće predvidjeti pojedinačni odgovor.
English: Appropriate dose titration should be considered.
Croatian: Treba razmisliti o odgovarajućoj titraciji doze.
English: · Do not freeze.
Croatian: Ne zamrzavati.
English: (7) Hold the OPC (One-Point-Cut) ampoule with the blue point upwards.
Croatian: (7) Držite OPC (One-Point-Cut) ampulu s plavom točkom prema gore.
English: Patients with cancer
Croatian: Bolesnici s rakom
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući lijekove koji se izdaju bez recepta.
English: Do not use glass materials for injection, use only plastic materials.
Croatian: Za injekcije nemojte upotrebljavati stakleni materijal, nego samo plastični.
English: Blood pressure monitoring
Croatian: Praćenje krvnog tlaka
English: Your doctor will always record the exact product you are using.
Croatian: Vaš liječnik će uvijek zabilježiti koji točno lijek uzimate.
English: In the absence of compatibility studies, this medicinal product should not be mixed with other medicinal products.
Croatian: Zbog nedostatka ispitivanja kompatibilnosti, ovaj lijek se ne smije miješati s drugim lijekovima.
English: The terminal half-life is higher than after intravenous administration, with an average of 13 - 28 hours.
Croatian: Terminalni poluvijek je viši nego nakon intravenske primjene, s prosjekom od 13 - 28 sati.
English: PRCA in patients with Hepatitis C
Croatian: PRCA u bolesnika s hepatitisom C
English: These may be signs of severely elevated blood pressure (hypertensive crisis), even if your blood pressure is usually normal or low.
Croatian: Ovo mogu biti znakovi vrlo povišenog krvnog tlaka (hipertenzivne krize), čak i ako Vam je krvni tlak obično normalan ili nizak.
English: Poorly controlled hypertension.
Croatian: Loše regulirana hipertenzija.
English: · Do not speed up the warming process in any way, and do not put the syringe in a microwave or in warm water.
Croatian: Nemojte ni na koji način ubrzavati proces zagrijavanja štrcaljke te je nemojte stavljati u mikrovalnu pećnicu ili toplu vodu.
English: Leaving the reconstituted solution outside the refrigerator should be limited to the time necessary for preparing the injections.
Croatian: Čuvanje pripremljene otopine izvan hladnjaka treba biti ograničeno na vrijeme potrebno za pripremu injekcije.
English: 1 Find a well-lighted, clean, flat, working surface.
Croatian: Pronađite dobro osvijetljenu, čistu i ravnu radnu površinu.
English: Particular attention should be paid to sudden stabbing migraine like headaches as a possible warning sign.
Croatian: Osobitu pažnju treba pridati iznenadnim probadajućim glavoboljama nalik migreni, kao mogućim znakovima upozorenja.
English: This is a multidose preparation from which different single doses can be withdrawn over a period of 1 month after dissolution.
Croatian: Ovo je višedozni pripravak iz kojeg se mogu izvlačiti različite pojedinačne doze tijekom razdoblja od 1 mjeseca nakon otapanja.
English: Other in-use storage times and conditions are the responsibility of the user.
Croatian: Za drugačije vrijeme i uvjete čuvanja odgovara korisnik.
English: As with all growth factors, there is a concern that epoetins could stimulate the growth of tumours.
Croatian: Kao i za sve faktore rasta, postoji bojazan da bi epoetini mogli stimulirati rast tumora.
English: L-Leucine,
Croatian: L-leucin,
English: · This medicine has been prescribed for you only.
Croatian: Ovaj je lijek propisan samo Vama.
English: This multidose preparation can be used for several patients.
Croatian: Ovaj višedozni pripravak se može primijeniti za više bolesnika.
English: Please discuss this with your doctor.
Croatian: Posavjetujte se o tome sa svojim liječnikom.
English: It can, however, be interrupted, if necessary, at any time.
Croatian: Može se, međutim, ako je to nužno, prekinuti u bilo kojem trenutku.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, and toxicity to reproduction.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti i reproduktivne toksičnosti.
English: Be careful when taking out the syringe.
Croatian: Budite oprezni pri vađenju štrcaljke.
English: In this case, proceed to step 19 and contact your healthcare provider.
Croatian: U tom slučaju prijeđite na 19. korak i obratite se svom zdravstvenom radniku.
English: Make sure you always hold the syringe as shown in the picture below.
Croatian: Štrcaljku obavezno uvijek držite kako je prikazano na slici.
English: Analogous results have been found in animal experiments in uraemic and normal rats.
Croatian: Analogni rezultati nađeni su u eksperimentima na životinjama u uremičnih i normalnih štakora.
English: (10) Before and after reconstitution NeoRecormon Multidose must be stored at +2° to +8°C (refrigerator).
Croatian: (10) Prije i nakon pripreme za primjenu NeoRecormon Multidose se mora čuvati na +2°C do +8°C (hladnjak).
English: (4) Replace the needle by a new one (the new needle should have the size which you normally use for injections).
Croatian: (4) Zamijenite iglu novom (nova igla treba biti veličine koju inače koristite za injekcije).
English: However, in controlled clinical studies no increased incidence of hypersensitivity reactions was found.
Croatian: Međutim, u kontroliranim kliničkim ispitivanjima nije zapažena povećana incidencija reakcija preosjetljivosti.
English: · Medicines should not be disposed of via wastewater or household waste.
Croatian: Lijekovi se ne smiju uklanjati putem otpadnih voda ili kućnog otpada.
English: Use the syringe within 5 minutes of removing the cap; otherwise, the needle may clog.
Croatian: Štrcaljku upotrijebite unutar 5 minuta nakon skidanja zatvarača; u protivnom bi se igla mogla začepiti.
English: Your doctor might prescribe acetylsalicylic acid or modify the shunt.
Croatian: Vam mogao propisati acetilsalicilatnu kiselinu ili modificirati šant.
English: NeoRecormon is administered twice weekly over 4 weeks.
Croatian: NeoRecormon se primjenjuje dva puta tjedno tijekom 4 tjedna.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updatespublished on the European medicines web-portal
Croatian: Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim sljedećim ažuriranim verzijama objavljenima na europskom internetskom portalu za lijekove.
English: These reactions were usually mild to moderate and went away within a few hours or days.
Croatian: Takve su reakcije obično blage do umjerene i nestaju unutar nekoliko sati ili dana.
English: · If you do not hear a click, look to see that the needle is fully covered by the safety shield.
Croatian: Ako ne čujete „klik“, provjerite je li igla u potpunosti prekrivena zaštitnim pokrovom.
English: Remark: If the syringe does not reach room temperature, this could cause the injection to feel uncomfortable and make it hard to push the plunger.
Croatian: Napomena: Ako štrcaljka ne dosegne sobnu temperaturu, injekcija će možda biti neugodna i možda će biti teško pritisnuti klip.
English: However, it can be interrupted at any time, if necessary.
Croatian: Međutim, ako je to nužno, može se prekinuti u bilo kojem trenutku.
English: Before you begin · Do not take the needle cap off until you are ready to inject NeoRecormon.
Croatian: Prije nego što počnete ● Nemojte skinuti zatvarač igle sve dok ne budete spremni injicirati NeoRecormon.
English: Every one or two weeks, the doctor may adjust your dose to find your individual maintenance dose.
Croatian: Svaki tjedan ili svaka dva tjedna liječnik može prilagođavati dozu kako bi pronašao dozu održavanja koja odgovara Vama.
English: See section 5.1
Croatian: Vidjeti dio 5.1
English: b) Maintaining sufficient red blood cell levels The maintenance dose: Once your red blood cells reach an acceptable level, the dose is reduced to half of the dose used to correct the anaemia.
Croatian: b) Održavanje dostatnog broja crvenih krvnih stanica Doza održavanja: Kad broj crvenih krvnih stanica dosegne zadovoljavajuću razinu, doza se smanjuje na polovicu doze korištene za korekciju anemije.
English: If it occurs, appropriate dose adjustment should be made as provided.
Croatian: Ako do toga dođe, potrebno je provesti odgovarajuću prilagodbu doze.
English: Water for injections.
Croatian: voda za injekcije.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: Prilikom svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: A carcinogenicity study with homologous erythropoietin in mice did not reveal any signs of proliferative or tumourigenic potential.
Croatian: Studija kancerogenosti homolognog eritropoetina u miševa nije pokazala nikakve znakove proliferativnog ili tumorogenog potencijala.
English: · Subcutaneous administration (under the skin).
Croatian: ● supkutana primjena (pod kožu).
English: In this case dose increases may be necessary.
Croatian: U tom slučaju može biti potrebno povećanje doze.
English: The injections of epoetin beta will increase the amount of blood that can be taken from your body before surgery and given back during or after the operation (this is an autologous transfusion).
Croatian: Injekcije epoetina beta povećavaju količinu krvi koja se može uzeti iz Vašeg tijela prije operacije i ponovo vratiti u tijelo nakon operacije (taj se postupak zove autologna transfuzija).
English: The initial weekly dose is 30,000 IU.
Croatian: Početna tjedna doza iznosi 30 000 IU.
English: The dose worked out by your doctor will be given twice per week for 4 weeks.
Croatian: Doza koju odredi Vaš liječnik će se davati dvaput tjedno tijekom 4 tjedna.
English: ·Do not inject into a red or swollen area.
Croatian: Nemojte injicirati u crveno ili natečeno područje.
English: Data on the once weekly dosing schedule are based on clinical studies with a treatment duration of 24 weeks.
Croatian: Podaci o režimu doziranja jednom tjedno, temelje se na kliničkim ispitivanjima s terapijom u trajanju od 24 tjedna.
English: · Choose a different injection site for each new injection.
Croatian: ● Za svaku novu injekciju odaberite drugo mjesto injiciranja.
English: Remark: If you have a multipack, put the carton with the remaining syringe(s) and needle(s) back into the refrigerator
Croatian: Napomena: Ako imate višestruko pakiranje, kutiju s preostalim štrcaljkama i iglama vratite u hladnjak
English: The clinical results obtained so far do not indicate any interaction of NeoRecormon with other medicinal products.
Croatian: Dosadašnji klinički rezultati ne upućuju na bilo kakvu interakciju lijeka NeoRecormon s drugim lijekovima.
English: · Do not reuse the same syringe.
Croatian: Nemojte ponovno upotrijebiti istu štrcaljku.
English: Even at very high blood levels, no symptoms of poisoning have been observed.
Croatian: Čak ni pri vrlo visokim razinama u krvi nisu primijećeni simptomi trovanja.
English: 9 Select a vein.
Croatian: 9. Odaberite venu.
English: Bioavailability of epoetin beta after subcutaneous administration is between 23 and 42 % as compared with intravenous administration.
Croatian: Bioraspoloživost epoetina beta nakon supkutane primjene je između 23% i 42% u usporedbi s intravenskom primjenom.