FrancophonIA/ELRC3.0 huggingface dataset:
English: Gastrointestinal disorders very common diarrhoea common vomiting, nausea, abdominal pain, increased blood amylase, dyspepsia, abdominal distension, flatulence uncommon pancreatitis, gastritis, gastrooesophageal reflux disease, aphthous stomatitis, retching, dry mouth, abdominal discomfort, constipation, increased lipase, eructation, oral dysaesthesia rare stomatitis, haematemesis, cheilitis, dry lip, coated tongue
Croatian: Poremećaji probavnog sustava vrlo često proljev često povraćanje, mučnina, bol u abdomenu, povišene amilaze u krvi, dispepsija, distenzija abdomena, flatulencija manje često pankreatitis, gastritis, gastroezofagealna refluksna bolest, aftozni stomatitis, dizanje želuca, suha usta, nelagoda u abdomenu, konstipacija, povišena lipaza, podrigivanje, oralna dizestezija rijetko stomatitis, hematemeza, heilitis, suhe usne, obložen jezik
English: It is recommended that the international normalised ratio (INR) be monitored when warfarin is combined with darunavir coadministered with low dose ritonavir.
Croatian: Preporučuje se praćenje protrombinskog vremena (INR, od engl. international normalised ratio) kada se varfarin primjenjuje u kombinaciji s darunavirom primijenjenog istodobno s niskom dozom ritonavira.
English: Viruses selected in these conditions and showing decreased susceptibility to darunavir (range: 23-50fold) harboured 2 to 4 amino acid substitutions in the protease gene.
Croatian: Odabrani virusi nisu mogli rasti u prisutnosti darunavira u koncentracijama iznad 400 nM. Virusi odabrani u tim uvjetima, koji su pokazivali smanjenu osjetljivost na darunavir (raspon: 23-50 puta) pohranili su 2 do 4 aminokiselinskih supstitucija u genu proteaze.
English: The usual dose of Darunavir Krka is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) once daily.
Croatian: Uobičajena doza lijeka Darunavir Krka je 800 miligrama (2 tablete koje sadrže 400 miligrama lijeka Darunavir Krka ili 1 tableta koja sadrži 800 miligrama lijeka Darunavir Krka) jedanput na dan.
English: OESTROGEN-BASED CONTRACEPTIVES Drospirenone
Croatian: NA BAZI ESTROGENA
English: Concomitant use of salmeterol and boosted darunavir may increase plasma concentrations of salmeterol.
Croatian: Istodobna primjena salmeterola i pojačanog darunavira može povećati koncentracije salmeterola u plazmi.
English: Renal impairment No dose adjustment is required in patients with renal impairment (see sections 4.4 and 5.2).
Croatian: U bolesnika s oštećenjem funkcije bubrega nije potrebna prilagodba doze (vidjeti dijelove 4.4 i 5.2).
English: Darunavir Krka 400 mg and 800 mg tablets may be used to provide suitable dose regimens for the treatment of HIV-1 infection in adult and paediatric patients from the age of 3 years and at least 40 kg body weight who are: antiretroviral therapy (ART)-naïve (see section 4.2).
Croatian: Darunavir Krka od 400 mg i 800 mg tablete mogu se primjenjivati da bi se osigurali prikladni režimi doziranja za liječenje HIV-1 infekcije u odraslih i pedijatrijskih bolesnika od 3 godine starosti i tjelesne težine barem 40 kg koji: - nisu prethodno liječeni antiretrovirusnom terapijom (ART) (vidjeti dio 4.2). - su prethodno liječeni ART-om, koji nemaju mutacije povezane s rezistencijom na darunavir (DRV-RAM) i koji imaju plazmatsku koncentraciju HIV-1 RNK
English: in certain patients who have used antiretroviral medicines before (your doctor will determine this).
Croatian: Doza za odrasle koji su već prije uzimali antiretrovirusne lijekove (to će odrediti Vaš liječnik)
English: Metabolism and nutrition disorders common diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia, hyperlipidaemia uncommon gout, anorexia, decreased appetite, decreased weight, increased weight, hyperglycaemia, insulin resistance, decreased high density lipoprotein, increased appetite, polydipsia, increased blood lactate dehydrogenase
Croatian: Poremećaji metabolizma i prehrane često dijabetes melitus, hipertrigliceridemija, hiperkolesterolemija, hiperlipidemija manje često giht, anoreksija, smanjen apetit, smanjena tjelesna težina, povećana tjelesna težina, hiperglikemija, rezistencija na inzulin, sniženi lipoproteini visoke gustoće, povećan apetit, polidipsija, povišena laktat dehidrogenaza u krvi
English: Clinical monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with darunavir with low dose ritonavir.
Croatian: Preporučeno je kliničko praćenje terapijskih učinaka i nuspojava kada se ovi lijekovi primjenjuju istodobno s pojačanim darunavirom.
English: ANTIGOUT MEDICINES Colchicine
Croatian: LIJEKOVI ZA LIJEČENJE GIHTA Kolhicin
English: 12 ART-naïve HIV-1 infected paediatric patients aged from 12 to 17 years and weighing at least 40 kg who received darunavir tablets with low dose ritonavir once daily in combination with other antiretroviral agents (see section 5.1).
Croatian: - 12 pedijatrijskih bolesnika u dobi od 12 do 17godina i težine najmanje 40kg, koji nisu prethodno liječeni ART-om, a inficirani su virusom HIV-1 te su primali darunavir tablete s niskom dozom ritonavira jedanput na dan u kombinaciji s drugim antiretrovirusnim lijekovima (vidjeti dio 5.1).
English: Recommendations concerning coadministration
Croatian: Preporuke vezane uz istodobnu primjenu
English: Bottle (HDPE), child resistant temper evident PP closure with a desiccant: - 30 tablets: 1 bottle of 30 film-coated tablets, - 60 tablets: 2 bottles of 30 film-coated tablets, - 90 tablets: 3 bottles of 30 film-coated tablets, - 180 tablets: 6 bottles of 30 film-coated tablets.
Croatian: Bočica (HDPE), PP zatvarač s evidencijom otvaranja siguran za djecu sa sredstvom za sušenje: - 30 tableta: 1 bočica s 30 filmom obloženih tableta, - 60 tableta: 2 bočice s 30 filmom obloženih tableta, - 90 tableta: 3 bočice s 30 filmom obloženih tableta, - 180 tableta: 6 bočica s 30 filmom obloženih tableta.
English: Human experience of acute overdose with darunavir co-administered with low dose ritonavir is limited.
Croatian: Iskustvo akutnog predoziranja u ljudi darunavirom primijenjenim istodobno s niskom dozom ritonavira je ograničeno.
English: Human experience of acute overdose with darunavir co-administered with cobicistat or low dose ritonavir is limited.
Croatian: Iskustvo akutnog predoziranja u ljudi darunavirom primijenjenim istodobno s kobicistatom ili niskom dozom ritonavira je ograničeno.
English: How to take Darunavir Krka
Croatian: Kako uzimati Darunavir Krka
English: The interaction profile of darunavir may differ depending on whether ritonavir or cobicistat is used as pharmacoenhancer.
Croatian: Profil interakcija darunavira može se razlikovati ovisno o tome je li kao farmakokinetički pojačivač korišten ritonavir ili kobicistat.
English: In women receiving darunavir/ritonavir 600/100 mg twice daily during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC12h and Cmin were 28%, 26% and 26% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC12h and Cmin values were 18%, 16% lower and 2% higher, respectively, as compared with postpartum.
Croatian: U žena koje su primale darunavir/ritonavir 600/100 mg dva puta na dan tijekom drugog tromjesečja trudnoće, srednje intra-individualne vrijednosti za ukupni darunavir Cmax, AUC12h i Cmin bile su 28%, 26% odnosno 26% niže, uspoređujući s postpartalnim razdobljem; tijekom trećeg tromjesečja trudnoće, vrijednosti za ukupni darunavir Cmax, AUC12h i Cmin bile su 18%, 16% niže, odnosno 2% više, uspoređujući s postpartalnim razdobljem.
English: Concominant use of everolimus or irinotecan and boosted darunavir is not recommended.
Croatian: Istodobno uzimanje everolimusa ili irinotekana i pojačanog darunavira se ne preporučuje.
English: Darunavir Krkacannot work properly without food.
Croatian: Darunavir Krka ne može pravilno djelovati bez hrane.
English: Darunavir Krka 800 mg film-coated tablets (tablets):
Croatian: Darunavir Krka 800 mg filmom obložene tablete (tablete):
English: Darunavir binds predominantly to 1-acid glycoprotein.
Croatian: Darunavir se pretežno veže na 1-kiseli glikoprotein.
English: (CYP3A and OATP1B inhibition)
Croatian: izloženost grazopreviru. (CYP3A i OATP1B inhibicija)
English: For patients with renal or hepatic impairment colchicine with darunavir co-administered with low dose ritonavir is contraindicated (see sections 4.3 and 4.4).
Croatian: Za bolesnike s oštećenjem bubrega ili jetre kolhicin s darunavirom primijenjenim istodobno s niskom dozom ritonavira je kontraindiciran (vidjeti dijelove 4.3 i 4.4).
English: Take Darunavir Krka always together with 100 milligram of ritonavir.
Croatian: - Lijek Darunavir Krka uvijek uzimajte zajedno sa 100 miligrama ritonavira.
English: In most cases, Darunavir Krka can be combined with anti-HIV medicines belonging to another class [e.g. NRTIs (nucleoside reverse transcriptase inhibitors), NNRTIs (non-nucleoside reverse transcriptase inhibitors), CCR5 antagonists and FIs (fusion inhibitors)].
Croatian: NRTI (nukleozidni inhibitori reverzne transkriptaze), NNRTI (ne-nukleozidni inhibitori reverzne transkriptaze), antagonisti receptora CCR5 i IF (inhibitori fuzije)].
English: Co-administration of darunavir coadministered with cobicistat and rifabutin is not recommended.
Croatian: Primjena darunavira istodobno primijenjenog s kobicistatom i rifabutinom se ne preporučuje.
English: 30 film-coated tablets: EU/1/17/1249/009 90 film-coated tablets: EU/1/17/1249/010
Croatian: 30 filmom obloženih tableta: EU/1/17/1249/009 90 filmom obloženih tableta: EU/1/17/1249/010
English: Boosted darunavir can be coadministered with proton pump inhibitors without dose adjustments.
Croatian: Pojačan darunavir može biti primijenjen istodobno s inhibitorima protonske pumpe bez prilagodbe doze.
English: Vascular disorders uncommon hypertension, flushing
Croatian: Krvožilni poremećaji manje često hipertenzija, navale vućine
English: If efavirenz is to be used in combination with darunavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used.
Croatian: Ako je potrebno primjenjivati efavirenz u kombinaciji s darunavirom, za darunavir/ritonavir se mora primijeniti režim od 600/100 mg dvaput na dan.
English: EU/1/17/1249/009 30 film-coated tablets EU/1/17/1249/010 90 film-coated tablets
Croatian: EU/1/17/1249/009 30 filmom obloženih tableta EU/1/17/1249/010 90 filmom obloženih tableta
English: Medicinal products that may be affected by darunavir boosted with cobicistat
Croatian: Lijekovi na koje može utjecati darunavir pojačan s kobicistatom
English: Pharmacokinetic results of total darunavir after administration of darunavir/ritonavir at 600/100 mg twice daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy and postpartum
Croatian: Farmakokinetički rezultati ukupnog darunavira nakon primjene darunavira/ritonavira 600/100 mg dvaput na dan, kao dijela antiretrovirusnog režima liječenja tijekom drugog trimestra trudnoće, trećeg trimestra trudnoće i postpartalnog razdoblja
English: If efavirenz is to be used in combination with darunavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used (see section 4.5).
Croatian: Ako je potrebno primjenjivati efavirenz u kombinaciji s darunavirom, za darunavir/ritonavir se mora primijeniti režim od 600/100 mg dvaput na dan (vidjeti dio 4.5).
English: The combination of rifapentine and darunavir with concomitant low dose ritonavir is not recommended.
Croatian: Kombinacija rifapentina i darunavira s istodobno primijenjenom niskom dozom ritonavira se ne preporučuje.
English: Co-administration of darunavir and ritonavir with medicinal products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Croatian: Istodobna primjena darunavira i ritonavira s lijekovima koji se primarno metaboliziraju putem CYP2C9 (poput varfarina) te CYP2C19 (poput metadona), može rezultirati smanjenjem sistemske izloženosti tim lijekovima, što može smanjiti ili skratiti njihov terapijski učinak.
English: At 48 weeks, virologic response, defined as the percentage of patients with plasma HIV-1 RNA level < 50 copies/ml, with darunavir/ritonavir 800/100 mg once daily treatment was demonstrated to be non-inferior (at the pre-defined 12% non-inferiority margin) compared to darunavir/ritonavir 600/100 mg twice daily for both ITT and OP populations.
Croatian: Nakon 48 tjedana, pokazalo se da virološki odgovor, definiran kao postotak bolesnika s razinom u plazmi HIV-1 RNK < 50 kopija/ml, nije inferioran uz liječenje darunavirom/ritonavirom od 800/100 mg jedanput na dan (pri prethodno definiranoj granici neinferiornosti od 12%) u usporedbi s darunavirom/ritonavirom od 600/100 mg dvaput na dan u ITT i OP populacijama.
English: If you forget to take Darunavir Krka If you notice within 6 hours, you must take your missed dose immediately.
Croatian: Ako ste zaboravili uzeti lijek Darunavir Krka Ako primijetite da niste uzeli lijek unutar 6 sati, tablete morate uzeti odmah, uvijek s ritonavirom i hranom.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with boosted darunavir is not recommended.
Croatian: Ne preporučuje se istodobna primjena tadalafila za liječenje plućne arterijske hipertenzije i pojačanog darunavira.
English: Third Trimester of pregnancy (n=15)
Croatian: Treće tromjesečje trudnoće (n=15)
English: 21 ART-experienced HIV-1 infected paediatric patients aged from 3 to < 6 years and weighing 10 kg to < 20 kg (16 participants from 15 kg to < 20 kg) who received darunavir oral suspension with low dose ritonavir twice daily in combination with other antiretroviral agents.
Croatian: - 21 pedijatrijski bolesnik u dobi od 3 do < 6godina i težine od 10kg do <20kg (16 ispitanika imalo je od 15 kg do < 20 kg), prethodno liječeni ART-om, a inficirani su virusom HIV-1 te su primali darunavir oralnu suspenziju s niskom dozom ritonavira dvaput na dan u kombinaciji s drugim antiretrovirusnim lijekovima.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with darunavir and low dose ritonavir is not recommended.
Croatian: Ne preporučuje se istodobna primjena tadalafila za liječenje plućne arterijske hipertenzije i darunavira s niskom dozom ritonavira.
English: In contrast to these data with darunavir /ritonavir, darunavir/cobicistat may increase these antidepressant plasma concentrations (CYP2D6 and/or CYP3A inhibition).
Croatian: Dezipramin Imipramin Nortriptilin Trazodon podatke s darunavirom/ritonavirom, darunavir/kobicistat može povisiti koncentracije tih antidepresiva u plazmi (CYP2D6 i/ili CYP3A inhibicija).
English: Darunavir Krka is available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a boxes.
Croatian: Darunavir Krka dostupne su u bočicama koje sadrže 30 filmom obloženih tableta (1 bočica s 30 filmom obloženih tableta), 60 filmom obloženih tableta (2 bočice s 30 filmom obloženih tableta), 90 filmom obloženih tableta (3 bočice s 30 filmom obloženih tableta) i 180 filmom obloženih tableta (6 bočica s 30 filmom obloženih tableta) u kutiji.
English: Darunavir with low dose ritonavir with triazolam or oral midazolam is contraindicated (see section 4.3)
Croatian: Darunavir s niskom dozom ritonavira je kontraindicirana s triazolamom ili oralnim midazolamom (vidjeti dio 4.3).
English: Your doctor should do blood tests before you start Darunavir Krka.
Croatian: Prije započinjanja lijeka Darunavir Krka liječnik Vam treba napraviti krvne pretrage.
English: Therefore, co-administration of darunavir with low dose ritonavir and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Croatian: Stoga je istodobna primjena darunavira s niskom dozom ritonavira i sildenafila kada se primjenjuje za liječenje plućne arterijske hipertenzije kontraindicirana (vidjeti dio 4.3).
English: The recommended dose of emtricitabine/tenofovir alafenamide is 200/10 mg once daily when used with darunavir with low dose ritonavir.
Croatian: Preporučena doza emtricitabin/tenofoviralafenamida kada se uzima s darunavirom s niskom dozom ritonavira je 200/10 mg jedanput na dan.
English: The combination of avanafil and boosted darunavir is contraindicated (see section 4.3).
Croatian: Kombinacija avanafila i pojačanog darunavira je kontraindicirana (vidjeti dio 4.3).
English: Respiratory, thoracic and mediastinal disorders uncommon dyspnoea, cough, epistaxis, throat irritation rare rhinorrhoea
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja manje često dispneja, kašalj, epistaksa, nadraženost grla rijetko rinoreja
English: A safe and effective dose of sildenafil for the treatment of pulmonary arterial hypertension co-administered with darunavir and low dose ritonavir has not been established.
Croatian: Nije ustanovljena sigurna i učinkovita doza sildenafila za liječenje pulmonalne arterijske hipertenzije s istodobnom primjenom darunavira primijenjenog istodobno s niskom dozom ritonavira.
English: Exposure to these immunosuppressants will be increased when co-administered with boosted darunavir.
Croatian: Izloženost tim imunosupresivima bit će povećana ako se primjenjuju istodobno s pojačanim darunavirom. (CYP3A inhibicija)
English: Darunavir must always be given orally with low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products (see section 5.2).
Croatian: Darunavir se uvijek mora primjenjivati peroralno s niskom dozom ritonavira koji pospješuje farmakokinetiku i u kombinaciji s drugim antiretrovirusnim lijekovima (vidjeti dio 5.2).
English: If efavirenz is to be used in combination with darunavir /ritonavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used (see section 4.4).
Croatian: Ako se efavirenz primjenjuje u kombinaciji s darunavirom/ritonavirom, mora se primijeniti darunavir/ritonavir 600/100 mg u režimu doziranja dvaput na dan (vidjeti dio 4.4).
English: Darunavir must always be given orally with cobicistat or low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products (see section 5.2).
Croatian: Darunavir se uvijek mora primjenjivati peroralno s kobicistatom ili niskom dozom ritonavira kao farmakokinetičkim pojačivačem, te u kombinaciji s drugim antiretrovirusnim lijekovima (vidjeti dio 5.2).
English: #, a comparable systemic exposure to sildenafil was observed for a single intake of 100 mg sildenafil alone and a single intake of 25 mg sildenafil co-administered with darunavir and low dose ritonavir.
Croatian: Sildenafil Tadalafil Vardenafil sistemska izloženost sildenafilu unosom jednokratne doze od 100 mg samo sildenafila i unosa jednokratne doze od 25 mg sildenafila istodobno primijenjenog s darunavirom i niskom dozom ritonavira.
English: The interaction profile of darunavir depends on whether ritonavir or cobicistat is used as pharmacokinetic enhancer.
Croatian: Interakcijski profil darunavira ovisi o tome je li kao farmakokinetički pojačivač korišten ritonavir ili kobicistat.
English: Darunavir boosted with cobicistat is more sensitive for CYP3A induction: concomitant use of darunavir/cobicistat and strong CYP3A inducers is therefore contraindicated (see section 4.3),and concomitant use with weak to moderate CYP3A inducers is not recommended (see section 4.5).
Croatian: Farmakokinetički pojačivači i istodobno primijenjeni lijekovi Profil interakcija darunavira različit je i ovisan o tome je li pojačan s ritonavirom ili s kobicistatom: - Darunavir pojačan s kobicistatom osjetljiviji je na CYP3A indukciju: stoga je kontraindicirana istodobna primjena darunavira/kobicistata i snažnih induktora CYP3A (vidjeti dio 4.3), te se ne preporučuje istodobna primjena sa slabim do umjerenim induktorima CYP3A (vidjeti dio 4.5).
English: Non-completer is failure imputation: patients who discontinued prematurely are imputed with a change equal to 0.
Croatian: Pripisane vrijednosti izračunate prema TLOVR algoritmu Bolesnik koji nije završio ispitivanje zabilježen je kao neuspjeh: bolesnicima koji su prijevremeno prekinuli ispitivanje pripisana je promjena jednaka 0.
English: Concomitant use of sildenafil or tadalafil for the treatment of pulmonary arterial hypertension and darunavir coadministered with low dose ritonavir may increase plasma concentrations of sildenafil or tadalafil.
Croatian: Istodobna primjena sildenafila ili tadalafila za liječenje plućne arterijske hipertenzije i darunavira primijenjenog istodobno s niskom dozom ritonavira može povećati koncentracije sildenafila ili tadalafila u plazmi. (CYP3A inhibicija)
English: 6/l (see section
Croatian: 6/l (vidjeti dijelove
English: Cobicistat and ritonavir inhibit CYP3A, thereby increasing the plasma concentrations of darunavir considerably.
Croatian: Kobicistat i ritonavir inhibiraju CYP3A te na taj način značajno povećavaju koncentracije darunavira u plazmi.
English: Once daily dosing Weight
Croatian: Doziranje jedanput na dan
English: Concomitant use of bosentan and boosted darunavir may increase plasma concentrations of bosentan.
Croatian: Istodobna primjena bosentana i pojačanog darunavira može povećati koncentracije bosentana u plazmi.
English: Patients with no/nonnaïve use of ENF Patients with naïve use of ENF
Croatian: Bolesnici koji prije nisu liječeni s ENF
English: Concomitant use of sildenafil or tadalafil for the treatment of pulmonary arterial hypertension and boosted darunavir may increase plasma concentrations of sildenafil or tadalafil.
Croatian: Istodobna primjena sildenafila ili tadalafila za liječenje plućne arterijske hipertenzije i pojačanog darunavira može povećati koncentracije sildenafila ili tadalafila u plazmi. (CYP3A inhibicija)
English: The use of these medicines with darunavir/cobicistat is contraindicated (see section 4.3).
Croatian: Primjena ovih lijekova s darunavirom/kobicistatom je kontraindicirana (vidjeti dio 4.3).
English: Boosted darunavir and rilpivirine can be used without dose adjustments.
Croatian: Pojačan darunavir i rilpivirin mogu se primijeniti bez prilagodbe doze.
English: In women receiving darunavir/cobicistat during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC24h and Cmin were 49%, 56% and 92% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC24h and Cmin values were 37%, 50% and 89% lower, respectively, as compared with postpartum.
Croatian: U žena koje uzimaju darunavir/kobicistat tijekom drugog tromjesečja trudnoće, srednje intra-individualne vrijednosti Cmax, AUC24h i Cmin za ukupni darunavir bile su 49%, 56% odnosno 92% niže u usporedbi s postpartalnim razdobljem; tijekom trećeg tromjesečja trudnoće, vrijednosti Cmax, AUC24h i Cminza ukupni darunavir bile su 37%, 50% i 89% niže u usporedbi s postpartalnim razdobljem.
English: It is not recommended to coadminister boosted darunavir and boceprevir.
Croatian: Ne preporučuje se istodobna primjena pojačanog darunavira i boceprevira.
English: Concominant use of everolimus or irinotecan and darunavir coadministered with low dose ritonavir is not recommended.
Croatian: Istodobno uzimanje everolimusa ili irinotekana i darunavira s niskom dozom ritonavira se ne preporučuje.
English: Based on theoretical considerations darunavir co-administered with cobicistat is expected to increase metformin plasma concentrations.
Croatian: Temeljem teorijskih postavki očekuje se da će darunavir istodobno primijenjen s kobicistatom povećati koncentracije metformina u plazmi.
English: Postpartum (6-12 weeks) (n=6)
Croatian: Postpartalno razdoblje (6-12 tjedana) (n=6)