FrancophonIA/ELRC3.0 huggingface dataset:
English: Tell your doctor if you are taking either of the following medicines, as treatment with VFEND at the same time should be avoided if possible, and a dose adjustment of voriconazole may be required:
Slovenian: Zdravniku povejte, če jemljete katerokoli od naslednjih zdravil, ker se je sočasnemu zdravljenju s temi zdravili in zdravilom VFEND treba, če je to mogoče, izogniti oz. bo morda potrebna prilagoditev odmerka vorikonazola:
English: Point the tip of the oral syringe towards the inside of the cheek.
Slovenian: Usmerite vrh peroralne brizge proti notranji strani lica.
English: Side effects with frequency not known: Freckles and pigmented spots
Slovenian: Neželeni učinki z neznano pogostnostjo: - pege in pigmentne lise
English: The combination of voriconazole with rifabutin should, if possible be avoided.
Slovenian: Sočasni uporabi vorikonazola in rifabutina se je treba, če je le mogoče, izogniti.
English: Serious side effects - Stop taking VFEND and see a doctor immediately
Slovenian: Resni neželeni učinki - prenehajte jemati zdravilo VFEND in nemudoma poiščite zdravnika
English: What you need to know before you take VFEND
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo VFEND
English: In clinical studies, response to voriconazole in patients with C. glabrata infections was 21% lower compared to C. albicans, C. parapsilosis and C. tropicalis.
Slovenian: V kliničnih študijah je bil odziv na vorikonazol pri bolnikih z okužbami s C. glabrata za 21 % manjši kot pri C. albicans, C. parapsilosis in C. tropicalis.
English: Fertility In an animal study, no impairment of fertility was demonstrated in male and female rats (see section 5.3).
Slovenian: Plodnost Študije na živalih niso pokazale zmanjšane plodnosti pri podganjih samcih in samicah (glejte poglavje
English: HDPE tablet containers containing 2, 30 or 100 film-coated tablets.
Slovenian: HDPE vsebniki s po 2, 30 ali 100 filmsko obloženimi tabletami.
English: When multiple doses of voriconazole oral suspension are administered with high fat meals, Cmax and AUCτ are reduced by 58% and 37% respectively.
Slovenian: Če se večkratne odmerke vorikonazola peroralne suspenzije uporablja z zelo mastnimi obroki, se Cmax zmanjša za 58 % in AUCτ za 37 %.
English: Digoxin Cmax ↔ Digoxin AUC ↔
Slovenian: digoksin Cmax ↔ digoksin AUC ↔
English: VFEND must not be taken during pregnancy, unless indicated by your doctor.
Slovenian: Zdravila VFEND se med nosečnostjo ne sme jemati, razen če tako ne odloči vaš zdravnik.
English: Each bottle contains 45 g of powder providing 70 ml of suspension when constituted with water as recommended.
Slovenian: Ena plastenka vsebuje 45 g praška, iz katerega dobimo po pripravi z vodo 70 ml suspenzije.
English: Oral bioavailability may, however, be limited in paediatric patients with malabsorption and very low body weight for their age.
Slovenian: Lahko pa je biološka uporabnost po peroralni uporabi omejena pri tistih pediatričnih bolnikih, ki imajo malabsorpcijo in zelo majhno telesno maso glede na starost.
English: Digoxin (0.25 mg QD) [P-gp substrate]
Slovenian: Digoksin (0,25 mg QD) [substrat P-gp]
English: 2a Snap open Blue port. Bend the outer tube by 90° each way to ensure it is fully broken.
Slovenian: Upogibajte zunanjo cevko za 90° v obe smeri, da zagotovite, da se popolnoma odlomi.
English: Preclinical data on the intravenous vehicle SBECD indicated that the main effects were vacuolation of urinary tract epithelium and activation of macrophages in the liver and lungs in the repeated-dose toxicity studies.
Slovenian: Predklinični podatki o intravenskem vehiklu SBECD so pokazali, da sta v študijah toksičnosti ponavljajočih se odmerkov glavna učinka vakuolizacija epitelija v sečilih in aktiviranje makrofagov v jetrih in pljučih.
English: If it appears to be a dry powder you should constitute the oral suspension by following the instructions below.
Slovenian: Če je v obliki praška, pripravite peroralno suspenzijo po sledečih navodilih:
English: 1 sterile, single use, foil overwrapped, polypropylene bag containing VFEND solvent for solution for infusion in one compartment (50 ml).
Slovenian: 1 sterilno, s folijo ovito polipropilensko vrečko za enkratno uporabo, ki vsebuje VFEND vehikel za raztopino za infundiranje v enem razdelku (50 ml).
English: When VFEND treatment is stopped by your doctor you should not experience any effects.
Slovenian: Ko bo zdravnik končal zdravljenje z zdravilom VFEND, ne bi smeli občutiti nobenih posledic.
English: Remove the syringe.
Slovenian: Odstranite brizgo.
English: The primary mode of action of voriconazole is the inhibition of fungal cytochrome P450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis.
Slovenian: Glavni mehanizem delovanja vorikonazola je zavrtje 14α-lanosterolske demetilacije, katero posreduje glivični citokrom P450 in ki je ključni korak v glivični biosintezi ergosterola.
English: VFEND must not be used during pregnancy, unless indicated by your doctor.
Slovenian: Zdravila VFEND se med nosečnostjo ne sme uporabiti, razen če tako ne odloči vaš zdravnik.
English: The visual impairments were generally mild, rarely resulted in discontinuation and were not associated with long-term sequelae.
Slovenian: Okvare vida so bile praviloma blage, redko so povzročile prekinitev zdravljenja in niso imele dolgoročnih posledic.
English: There is a small chance that skin cancer could develop with long-term use of VFEND.
Slovenian: Pri dolgotrajni uporabi zdravila VFEND obstaja majhna verjetnost pojava raka kože.
English: Blood products and short-term infusion of concentrated solutions of electrolytes: Electrolyte disturbances such as hypokalaemia, hypomagnesaemia and hypocalcaemia should be corrected prior to initiation of voriconazole therapy (see sections 4.2 and 4.4).
Slovenian: Krvni pripravki in kratkotrajne infuzije koncentriranih raztopin elektrolitov: Motnje elektrolitov, kot so hipokaliemija, hipomagneziemija in hipokalciemija, morajo biti korigirane pred začetkom zdravljenja z vorikonazolom (glejte poglavji 4.2 in 4.4).
English: VFEND 200 mg film-coated tablets Each tablet contains 253.675 mg lactose monohydrate.
Slovenian: VFEND 200 mg filmsko obložene tablete Ena tableta vsebuje 253,675 mg laktoze monohidrata.
English: Coadministration of standard doses of voriconazole with efavirenz doses of 400 mg once daily or higher is contraindicated, because efavirenz significantly decreases plasma voriconazole concentrations in healthy subjects at these doses.
Slovenian: Sočasna uporaba standardnih odmerkov vorikonazola z odmerki efavirenza v velikosti 400 mg enkrat na dan ali več je kontraindicirana, ker efavirenz pri takšnih odmerkih pomembno zmanjša plazemsko koncentracijo vorikonazola pri zdravih preskušancih.
English: Powder and solvent for solution for infusion Each pack contains:
Slovenian: prašek in vehikel za raztopino za infundiranje Vsako pakiranje vsebuje:
English: Take your suspension at least one hour before, or two hours after a meal.
Slovenian: Suspenzijo vzemite vsaj eno uro pred jedjo ali dve uri po jedi.
English: If multiple vials are required, each individual vial used must be administered using a separate sterile sodium chloride bag.
Slovenian: Če je treba uporabiti več vial, morate za dajanje vsake posamezne viale uporabiti novo sterilno vrečko natrijevega klorida.
English: Instructions to constitute the suspension:
Slovenian: Navodilo za pripravo suspenzije:
English: Film-coating Hypromellose Titanium dioxide (E171) Lactose monohydrate Glycerol triacetate
Slovenian: Filmska obloga hipromeloza titanov dioksid (E171) laktoza monohidrat triacetin
English: The overall incidence of transaminase increases >3 xULN (not necessarily comprising an adverse event) in the voriconazole clinical programme was 18.0% (319/1,768) in adults and 25.8% (73/283) in paediatric subjects who received voriconazole for pooled therapeutic and prophylaxis use.
Slovenian: Celokupna incidenca zvišanja ravni aminotransferaz na > 3-kratnik zgornje meje normalnih vrednosti [ZMN] (kar ni nujno pomenilo neželenega učinka) je bila pri preskušancih, ki so prejemali vorikonazol pri terapevtski in profilaktični uporabi v kliničnem programu vorikonazola 18,0 % (319/1.768) pri odraslih in 25,8 % (73/283) pri pediatričnih preskušancih.
English: Success at Day 180*
Slovenian: Uspešnost na 180. dan*
English: Reactions during the infusion have occurred uncommonly with VFEND (including flushing, fever, sweating, increased heart rate and shortness of breath).
Slovenian: Občasno so se med infundiranjem zdravila VFEND pojavile reakcije (vključno z zardevanjem, vročino, znojenjem, pospešenim srčnim utripom in kratko sapo).
English: Reconstituted VFEND concentrate needs to be further diluted with sodium chloride (0.9%) infusion solution within the infusion bag before it is infused.
Slovenian: Rekonstituirani koncentrat VFEND je treba pred infundiranjem dodatno redčiti z vehiklom za infundiranje z natrijevim kloridom (0,9 %), ki se nahaja v infuzijski vrečki.
English: Therapy must be initiated with the specified loading dose regimen of either intravenous or oral VFEND to achieve plasma concentrations on Day 1 that are close to steady state.
Slovenian: Zdravljenje je treba začeti z navedenim polnilnim odmerjanjem intravenskega ali peroralnega zdravila VFEND, da se 1. dan doseže plazemsko koncentracijo, ki je blizu stanja dinamičnega ravnovesja.
English: VFEND should be administered primarily to patients with progressive, possibly life-threatening infections.
Slovenian: Zdravilo VFEND je namenjeno predvsem uporabi pri bolnikih z napredujočimi, potencialno življenjsko nevarnimi okužbami.
English: Itraconazole (N=109)
Slovenian: Itrakonazol (n = 109)
English: As VFEND has been known to affect the liver and the kidney, your doctor should monitor the function of your liver and kidney by doing blood tests.
Slovenian: Ker je znano, da lahko zdravilo VFEND prizadene jetra in ledvice, mora zdravnik s krvnimi preiskavami nadzirati delovanje vaših jeter in ledvic.
English: 1 syringe
Slovenian: 1 brizgo
English: VFEND is an antifungal medicine.
Slovenian: Zdravilo VFEND je protiglivično zdravilo.
English: Carbamazepine and long-acting barbiturates (e.g., phenobarbital, mephobarbital) [potent CYP450 inducers]
Slovenian: Karbamazepin in dolgodelujoči barbiturati (kot so fenobarbital, mefobarbital) [močni induktorji CYP450]
English: No subject experienced an interval exceeding the potentially clinically-relevant threshold of 500 msec (see section 5.1).
Slovenian: Pri nobenem od preskušancev ni prišlo do podaljšanja intervala prek potencialno klinično pomembnih 500 milisekund (glejte poglavje 5.1).
English: This product should only be used under the supervision of a doctor.
Slovenian: To zdravilo se sme uporabljati samo pod zdravniškim nadzorom.
English: Do not remove casing.
Slovenian: Ohišja ne odstranite.
English: In patients with moderate to severe renal dysfunction (serum creatinine levels > 2.5 mg/dl), accumulation of the intravenous vehicle, SBECD, occurs (see sections 4.2 and 4.4).
Slovenian: Pri bolnikih z zmerno do hudo prizadetim delovanjem ledvic (koncentracija kreatinina v serumu > 2,5 mg/dl) se pojavi kopičenje intravenskega vehikla SBECD (glejte poglavji 4.2 in 4.4).
English: In the table below, since the majority of the studies were of an open nature, all causality adverse reactions and their frequency categories in 1,873 adults from pooled therapeutic (1,603) and prophylaxis (270) studies, by system organ class, are listed.
Slovenian: Ker je bila večina študij odprtega tipa, spodnja preglednica navaja neželene učinke vseh vzrokov skupaj s pripadajočimi pogostnostmi pojavljanja pri 1.873 odraslih v združenih podatkih iz terapevtskih (1.603) in profilaktičnih študij (270).
English: In clinical studies, response to voriconazole in C. krusei infections was similar to C. albicans, C. parapsilosis and C. tropicalis.
Slovenian: V kliničnih študijah je bil odziv na vorikonazol pri okužbah s C. krusei podoben kot pri C. albicans, C. parapsilosis in C. tropicalis.
English: • Alfentanil and fentanyl and other short-acting opiates such as sufentanil (painkillers used for surgical procedures)
Slovenian: • alfentanil, fentanil in druge kratkodelujoče opiate, npr. sufentanil (zdravila proti bolečinam, ki se uporabljajo pri operacijah)
English: • Benzodiazepines (e.g midazolam, triazolam) (used for severe insomnia and stress)
Slovenian: • benzodiazepine (npr. midazolam, triazolam) (uporabljajo se pri hudi nespečnosti in stresu)
English: The findings of the effect of efavirenz on voriconazole suggest that the metabolism of voriconazole may be induced by an NNRTI.
Slovenian: Ugotovitve učinkov efavirenza na vorikonazol nakazujejo, da je metabolizem vorikonazola lahko induciran z NNRTI.
English: Ibuprofen (400 mg single dose)
Slovenian: ibuprofen (enkratni 400 mg odmerek)
English: Coadministration of voriconazole and low-dose ritonavir (100 mg BID) should be avoided unless an assessment of the benefit/risk to the patient justifies the use of voriconazole.
Slovenian: Sočasni uporabi vorikonazola in manjših odmerkov ritonavirja (100 mg BID) se je treba izogniti, razen če ocena koristi in tveganja za bolnika opraviči uporabo vorikonazola.
English: VFEND 50 mg film-coated tablets Each tablet contains 63.42 mg lactose monohydrate.
Slovenian: VFEND 50 mg filmsko obložene tablete Ena tableta vsebuje 63,42 mg laktoze monohidrata.
English: Marketing Authorisation Holder Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgium.
Slovenian: Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgija
English: 2 film-coated tablets 10 film-coated tablets 14 film-coated tablets 20 film-coated tablets 28 film-coated tablets 30 film-coated tablets 50 film-coated tablets 56 film-coated tablets 100 film-coated tablets
Slovenian: 2 filmsko obloženi tableti 10 filmsko obloženih tablet 14 filmsko obloženih tablet 20 filmsko obloženih tablet 28 filmsko obloženih tablet 30 filmsko obloženih tablet 50 filmsko obloženih tablet 56 filmsko obloženih tablet 100 filmsko obloženih tablet
English: If you are already being treated with phenytoin your blood concentration of phenytoin will need to be monitored during your treatment with VFEND and your dose may be adjusted.
Slovenian: Če se že zdravite s fenitoinom, je treba med zdravljenjem z zdravilom VFEND nadzirati koncentracijo fenitoina v krvi in morda prilagoditi odmerek.
English: What VFEND looks like and contents of the pack
Slovenian: Izgled zdravila VFEND in vsebina pakiranja
English: • invasive aspergillosis (a type of fungal infection due to Aspergillus sp),
Slovenian: • z invazivno aspergilozo (vrsta glivične okužbe, ki jo povzročajo vrste Aspergillus),
English: Method of administration VFEND film-coated tablets are to be taken at least one hour before, or one hour following, a meal.
Slovenian: Zdravilo VFEND filmsko obložene tablete je treba vzeti vsaj eno uro pred jedjo ali najmanj eno uro po jedi.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking VFEND.
Slovenian: Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred uporabo tega zdravila posvetujte z zdravnikom.
English: The plasma protein binding of voriconazole was similar in subjects with different degrees of renal impairment (see sections 4.2 and 4.4).
Slovenian: Vezava vorikonazola na beljakovine v plazmi je bila pri preskušancih z različno izrazito ledvično okvaro podobna (glejte poglavji 4.2 in 4.4).
English: Itraconazole (N=143)
Slovenian: Itrakonazol (n = 143)
English: If you forget to take VFEND
Slovenian: Če ste pozabili vzeti zdravilo VFEND
English: • To prepare the VFEND vial for reconstitution, remove the plastic cap from the vial and wipe the top with an antiseptic swab.
Slovenian: • Za pripravo VFEND viale na rekonstitucijo odstranite plastični pečat z viale in obrišite vrh viale z antiseptičnim zložencem.
English: Any remaining suspension should be discarded 14 days after constitution.
Slovenian: Morebitno preostalo suspenzijo zavrzite 14 dni po pripravi.
English: • tell your doctor immediately if you develop o sunburn o severe skin rash or blisters o bone pain
Slovenian: • zdravniku takoj povejte, če se vam pojavijo - sončne opekline, - hud izpuščaj ali mehurji na koži, - bolečine v kosteh.
English: Non-Steroidal AntiInflammatory Drugs (NSAIDs) [CYP2C9 substrates]
Slovenian: Nesteroidna protivnetna zdravila (NSAID) [substrati CYP2C9]
English: 5a Invert the infusion bag and screw the syringe into Blue port.
Slovenian: 5a Infuzijsko vrečko obrnite s spodnjim koncem navzgor in privijte brizgo na modri priključek.
English: Cimetidine (400 mg BID) [non-specific CYP450 inhibitor and increases gastric pH]
Slovenian: Cimetidin (400 mg BID) [nespecifičen zaviralec CYP450 in zvišuje pH v želodcu]
English: Itraconazole N=241
Slovenian: Itrakonazol n = 241
English: • The VFEND solvent for solution for infusion is then added to the vial by unscrewing the syringe from the bag, connecting it to the vial adapter and then emptying the contents from the syringe into the vial.
Slovenian: • VFEND vehikel za raztopino za infundiranje nato dodajte v vialo tako, da najprej brizgo odvijte z vrečke, nato pa jo spojite z nastavkom za vialo in izpraznite vsebino brizge v vialo.
English: Reconstitute and dilute before use - see leaflet.
Slovenian: Pred uporabo pripravite in razredčite - glejte navodilo.
English: Further information is provided for medical or healthcare professionals at the end of the Package Leaflet.
Slovenian: Nadaljnje informacije za zdravstvene delavce se nahajajo na koncu navodila za uporabo.
English: Caution should be used in prescribing VFEND to patients with hypersensitivity to other azoles (see also section 4.8).
Slovenian: Pri predpisovanju zdravila VFEND bolnikom, preobčutljivim za druge azole, je potrebna previdnost (glejte tudi poglavje 4.8).
English: Tacrolimus Cmax  117% Tacrolimus AUCt  221%
Slovenian: takrolimus Cmax  117 % takrolimus AUCt  221 %
English: Long term exposure (treatment or prophylaxis) greater than 180 days (6 months) requires careful assessment of the benefit-risk balance and physicians should therefore consider the need to limit the exposure to VFEND (see sections 4.2 and 5.1).
Slovenian: Pri dolgotrajni izpostavljenosti (pri zdravljenju ali profilaksi), daljši od 180 dni (6 mesecev), je treba natančno oceniti razmerje med koristmi in tveganji, zato morajo zdravniki razmisliti o potrebi po zmanjšanju izpostavljenosti zdravilu VFEND (glejte poglavji 4.2 in 5.1).
English: As the half-life of alfentanil is prolonged in a 4-fold manner when alfentanil is coadministered with voriconazole, and in an independent published study concomitant use of voriconazole with fentanyl resulted in an increase in the mean AUC0-∞ of fentanyl, frequent monitoring for opiateassociated adverse reactions (including a longer respiratory monitoring period) may be necessary.
Slovenian: Razpolovni čas alfentanila se ob sočasni uporabi z vorikonazolom 4-krat podaljša, v objavljeni neodvisni študiji pa je imela sočasna uporaba vorikonazola skupaj s fentanilom za posledico povečanje povprečne vrednosti AUC0-∞ fentanila, zato utegne biti potreben pogostejši nadzor z opiati povezanih neželenih učinkov (vključno z daljšim obdobjem respiratornega nadzora).
English: Ritonavir (potent CYP450 inducer; CYP3A4 inhibitor and substrate) Coadministration of voriconazole and low-dose ritonavir (100 mg twice daily) should be avoided unless an assessment of the benefit/risk to the patient justifies the use of voriconazole (see sections 4.3 and 4.5).
Slovenian: Ritonavir (močan induktor CYP450; zaviralec in substrat CYP3A4) Sočasni uporabi vorikonazola in nižjih odmerkov ritonavirja (100 mg dvakrat na dan) se je treba izogniti, razen če ocena koristi in tveganja pri bolniku opraviči uporabo vorikonazola (glejte poglavji 4.3 in 4.5).
English: Sulfonylureas (e.g., tolbutamide, glipizide, glyburide) [CYP2C9 substrates]
Slovenian: Sulfonilsečnine (kot so tolbutamid, glipizid, gliburid) [substrati CYP2C9]
English: Shake the closed bottle vigorously for about 1 minute.
Slovenian: Zaprto plastenko močno stresajte približno 1 minuto.
English: Take your box of VFEND tablets with you.
Slovenian: S seboj vzemite škatlico zdravila VFEND.
English: 50 ml infusion bag containing 0.9% of sodium chloride.
Slovenian: 50 ml infuzijska vrečka, ki vsebuje 0,9 % natrijev klorid.
English: Fentanyl (5 g/kg single dose)
Slovenian: fentanil (enkratni 5 g/kg odmerek)
English: Each tablet contains either 50 mg voriconazole (for VFEND 50 mg film-coated tablets) or 200 mg voriconazole (for VFEND 200 mg film-coated tablets).
Slovenian: Ena tableta vsebuje 50 mg vorikonazola (velja za VFEND 50 mg filmsko obložene tablete) ali 200 mg vorikonazola (velja za VFEND 200 mg filmsko obložene tablete).
English: Depending on your response to treatment, your doctor may decrease the dose to 3 mg/kg twice daily.
Slovenian: Odvisno od vašega odziva na zdravljenje bo vaš zdravnik morda zmanjšal odmerek na 3 mg/kg dvakrat na dan.
English: The placeboadjusted mean maximum increases in QTc from baseline after 800, 1200 and 1600 mg of voriconazole were 5.1, 4.8, and 8.2 msec, respectively and 7.0 msec for ketoconazole 800 mg. No subject in any group had an increase in QTc of ≥ 60 msec from baseline.
Slovenian: Placebu prirejeno povprečno največje podaljšanje QTc, glede na izhodišče po 800, 1200 in 1600 mg vorikonazola, je bilo 5,1; 4,8 in 8,2 milisekunde ter 7,0 milisekund po 800 mg ketokonazola.
English: Rifampicin (600 mg QD) [potent CYP450 inducer]
Slovenian: Rifampicin (600 mg QD) [močan induktor CYP450]
English: Shake bottle for approximately 10 seconds before use.
Slovenian: Pred uporabo plastenko stresajte približno 10 sekund.
English: If a patient develops skeletal pain and radiologic findings compatible with periostitis VFEND discontinuation should be considered after multidisciplinary advice.
Slovenian: Če se pri bolniku pojavi bolečina v skeletu in rezultati radiološke preiskave nakazujejo na periostitis, je treba po obravnavati s strani več zdravnikov specialistov razmisliti o prekinitvi zdravljenja z zdravilom VFEND.
English: Coadministration with high-dose ritonavir (400 mg and above twice daily) because ritonavir significantly decreases plasma voriconazole concentrations in healthy subjects at this dose (see section 4.5, for lower doses see section 4.4).
Slovenian: Sočasna uporaba z velikimi odmerki ritonavirja (400 mg in več, dvakrat na dan), ker ritonavir pri takšnih odmerkih pomembno zmanjša plazemsko koncentracijo vorikonazola pri zdravih preskušancih (glejte poglavje 4.5, za nižje odmerke glejte poglavje 4.4).
English: When multiple doses of voriconazole are administered with high fat meals, Cmax and AUCτ are reduced by 34% and 24%, respectively.
Slovenian: Če se večkratne odmerke vorikonazola uporablja z zelo mastnimi obroki, se Cmax zmanjša za 34 % in AUCτ za 24 %.
English: VFEND should be discontinued if premalignant skin lesions or squamous cell carcinoma are identified (see below the section under Long-term treatment).
Slovenian: Če se odkrijejo predrakave lezije na koži ali ploščatocelični karcinom kože, je treba zdravljenje z zdravilom VFEND prekiniti (glejte spodnje poglavje Dolgotrajno zdravljenje).
English: VFEND is a single dose unpreserved sterile lyophile.
Slovenian: Zdravilo VFEND je en odmerek sterilnega liofilizata brez konzervansov.
English: VFEND is intended for patients with worsening, possibly life-threatening, fungal infections.
Slovenian: Zdravilo VFEND je namenjeno bolnikom, pri katerih se glivična okužba poslabšuje in je morda življenjsko nevarna.
English: Astemizole, cisapride, pimozide, quinidine and terfenadine [CYP3A4 substrates]
Slovenian: Astemizol, cisaprid, pimozid, kinidin in terfenadin [substrati CYP3A4]
English: • Once the syringe is reconnected to the blue port of the infusion bag, the contents are then emptied into the infusion bag from the syringe to provide a final voriconazole solution containing 0.5-5 mg/ml.
Slovenian: • Potem, ko brizgo ponovno spojite z modrim priključkom na infuzijski vrečki, izpraznite vsebino brizge v infuzijsko vrečko, da dobite končno raztopino vorikonazola s koncentracijo 0,5-5 mg/ml.