FrancophonIA/ELRC3.0 huggingface dataset:
English: This conclusion is based on the physiochemical and pharmacokinetic data, assuming that the patient crushes and transfers 100% of the tablet and ingests immediately.
Slovenian: Ta zaključek temelji na fizikalnokemijskih in farmakokinetičnih podatkih ter predpostavki, da bolnik tableto zdrobi in jo nato v celoti doda redki hrani ali tekočini ter takoj zaužije.
English: Alternatively, for patients who are unable to swallow tablets, the tablet(s) may be crushed and added to a small amount of semi-solid food or liquid, all of which should be consumed immediately (see section 5.2).
Slovenian: Bolnik, ki tablet ne more pogoltniti, lahko tablete tudi zdrobi in jih doda v manjšo količino redke hrane ali tekočine, ki jo mora nato v celoti takoj zaužiti (glejte poglavje 5.2).
English: The limited data available indicate that an oral solution dose of 2 mg/kg in neonates less than 30 days old provides similar or greater AUCs, compared to the 8 mg/kg oral solution dose administered to older children.
Slovenian: Omejeno število podatkov, ki so na razpolago, kaže, da odmerek peroralne raztopine 2 mg/kg pri novorojenčkih, mlajših od 30 dni, zagotavlja podobne ali večje AUC v primerjavi z odmerkom peroralne raztopine 8 mg/kg, ki ga dajemo starejšim otrokom.
English: One randomised, double blind, placebo controlled clinical study in adults has compared the combination of abacavir, lamivudine and zidovudine to the combination of indinavir, lamivudine and zidovudine.
Slovenian: V randomizirani, dvojno slepi in s placebom kontrolirani študiji na odraslih bolnikih so primerjali kombinacijo abakavirja, lamivudina in zidovudina s kombinacijo indinavirja, lamivudina in zidovudina.
English: Clinical studies have shown that there are no clinically significant interactions between abacavir, zidovudine, and lamivudine.
Slovenian: Klinične študije so tudi pokazale, da med abakavirjem, zidovudinom in lamivudinom ni klinično pomembnih interakcij.
English: Ziagen oral solution contains 340 mg/ml of sorbitol.
Slovenian: Zdravilo Ziagen peroralna raztopina vsebuje 340 mg/ml sorbitola.
English: For example, if your dose is 30 ml, you need to take 3 syringe-fulls of medicine Take the syringe out of the bottle and wash it thoroughly in clean water.
Slovenian: Na primer če je vaš odmerek 30 ml, morate vzeti 3 napolnjene brizge z zdravilom.
English: There are no data available on the safety of abacavir when administered to babies less than three months old.
Slovenian: Podatkov o varnosti abakavirja pri dajanju dojenčkom, mlajšim od treh mesecev, nimamo.
English: Plasma protein binding studies in vitro indicate that abacavir binds only low to moderately (~49%) to human plasma proteins at therapeutic concentrations.
Slovenian: Študije o vezavi na plazemske beljakovine in vitro kažejo, da je vezava abakavirja na humane plazemske beljakovine pri terapevtskih koncentracijah majhna do zmerna (~49 %).
English: The antiviral activity of abacavir in cell culture was not antagonized when combined with the nucleoside reverse transcriptase inhibitors (NRTIs) didanosine, emtricitabine, lamivudine, stavudine, tenofovir or zidovudine, the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, or the protease inhibitor (PI) amprenavir.
Slovenian: Protivirusno delovanje abakavirja v celični kulturi ni bilo antagonistično v kombinaciji z nukleozidnimi zaviralci reverzne transkriptaze (NRTI) didanozinom, emtricitabinom, lamivudinom, stavudinom, tenofovirjem ali zidovudinom, nenukleozidnim zaviralcem reverzne transkriptaze (NNRTI) nevirapinom ali zaviralcem proteaz (PI) amprenavirjem.
English: The scored tablets are yellow and capsule-shaped and are provided in blister packs containing 60 tablets.
Slovenian: Tablete z razdelilno zarezo so rumene barve in v obliki kapsule ter so pakirane v pretisnih omotih po 60 tablet.
English: • a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome), and a more severe form causing skin peeling in more than 30% of the body surface (toxic epidermal necrolysis)
Slovenian: • razširjen izpuščaj z mehurji in lupljenjem kože, zlasti okrog ust, nosu, oči in spolovil (StevensJohnsonov sindrom), ter hujša oblika, ki povzroči lupljenje več kot 30 % površine telesa (toksična epidermalna nekroliza),
English: Abacavir is also excreted into human milk.
Slovenian: Abakavir se izloča tudi v materino mleko pri človeku.
English: When full, the syringe contains 10 ml of solution.
Slovenian: Ko je brizga polna vebuje 10 ml raztopine.
English: Abacavir has been shown to be carcinogenic in animal models (see section 5.3).
Slovenian: Abakavir se je izkazal za karcinogenega v študijah na živalih (glejte poglavje 5.3).
English: These findings included decreased foetal body weight, foetal oedema, and an increase in skeletal variations/malformations, early intra-uterine deaths and still births.
Slovenian: Te ugotovitve vključujejo zmanjšanje telesne mase ploda, edeme ploda in porast skeletnih variacij/malformacij, zgodnje intrauterine smrti in mrtvorodnost.
English: However, both analyses were compatible with a conclusion of non-inferiority between both treatment arms.
Slovenian: Kljub vsemu pa se obe analizi skladata z zaključkom, da sta si bila oba uporabljena režima zdravljenja enakovredna.
English: The overall selection frequency for M184V or M184I was high (54%), and less common was the selection of L74V (5%), K65R (1%) and Y115F (1%).
Slovenian: Celotna pogostnost selekcije M184V ali M184I je bila visoka (54 %), redkejše so bile selekcije L74V (5 %), K65R (1 %) in Y115F (1 %).
English: Contents of the pack and other information What Ziagen contains
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Ziagen
English: The mean (CV) AUC over a dosing interval of 12 hours was 6.02 µg.h/ml (29%), equivalent to a daily AUC of approximately 12.0 µg.h/ml.
Slovenian: Srednja (CV) AUC v 12-urnem odmernem intervalu je bila 6,02 µg.h/ml (29 %), kar je ekvivalentno dnevnemu AUC približno 12,0 µg.h/ml.
English: The results are summarised in the table below:
Slovenian: Rezultati so prikazani v spodnji preglednici:
English: IMPORTANT - ALERT CARD ZIAGEN (abacavir) tablets Carry this card with you at all times
Slovenian: POMEMBNO - OPOZORILNA KARTICA ZIAGEN (abakavir) tablete To kartico vedno nosite s seboj
English: Do not drive or operate machines unless you are feeling well.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Ne upravljajte vozil ali strojev, če se ne počutite dobro.
English: Patients being treated with methadone and abacavir should be monitored for evidence of withdrawal symptoms indicating under dosing, as occasionally methadone re-titration may be required.
Slovenian: Pri bolnikih, ki se zdravijo z metadonom in abakavirjem, moramo biti pozorni na morebitni pojav abstinenčnih znakov, ki pričajo o prenizkem odmerjanju, saj bo občasno morda treba zvišati odmerek metadona.
English: Any two NRTIassociated mutations Any three NRTIassociated mutations Four or more NRTIassociated mutations
Slovenian: Katerikoli dve mutaciji, povezani z NRTI Katerekoli tri mutacije, povezane z NRTI
English: This potential difference is sufficiently small to draw an overall conclusion of noninferiority of abacavir once daily over abacavir twice daily.
Slovenian: Ta možna razlika je dovolj majhna, da lahko postavimo končen zaključek, da sta si režima odmerjanja abakavirja enkrat ali dvakrat na dan enakovredna.
English: Some medicines interact with Ziagen
Slovenian: Nekatera zdravila medsebojno delujejo z zdravilom Ziagen
English: The bottle contains 240 ml (20 mg abacavir/ml) of solution.
Slovenian: Steklenica vsebuje 240 ml (20 mg abakavirja/ml) raztopine.
English: Therefore patients should remain under close clinical observation by physicians experienced in the treatment of these associated HIV diseases.
Slovenian: Zato morajo bolnike ves čas natančno klinično opazovati zdravniki, ki imajo izkušnje z zdravljenjem bolezni,
English: Let it dry completely before you use it again
Slovenian: Pred ponovno uporabo mora biti popolnoma suha.
English: 1206 HIV-infected paediatric patients aged 3 months to 17 years were enrolled in the ARROW Trial (COL105677), 669 of whom received abacavir and lamivudine either once or twice daily (see section 5.1).
Slovenian: 1206 pediatričnih bolnikov okuženih z virusom HIV, starih od 3 mesece do 17 let, so vključili v preskušanje ARROW (COL105677), pri čemer jih je 669 prejemalo abakavir in lamivudin bodisi enkrat ali dvakrat na dan (glejte poglavje 5.1).
English: After 36 weeks on a regimen including twice daily abacavir and lamivudine, 669 eligible subjects were randomised to either continue twice daily dosing or switch to once daily abacavir and lamivudine for at least 96 weeks.
Slovenian: Po 36 tednih režima odmerjanja, ki je vključeval abakavir in lamivudin dvakrat na dan, so 669 primernih preiskovancev randomizirali bodisi na nadaljevanje uporabe dvakrat na dan bodisi na prehod na uporabo abakavirja in lamivudina enkrat na dan za vsaj 96 tednov.
English: Abacavir belongs to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Slovenian: Abakavir spada v skupino protiretrovirusnih zdravil, ki jih imenujemo nukleozidni zaviralci reverzne transkriptaze (ZNRT).
English: IMPORTANT - ALERT CARD ZIAGEN (abacavir) oral solution Carry this card with you at all times
Slovenian: POMEMBNO - OPOZORILNA KARTICA ZIAGEN (abakavir) peroralna raztopina To kartico vedno nosite s seboj
English: Methadone: in a pharmacokinetic study, co-administration of 600 mg abacavir twice daily with methadone showed a 35% reduction in abacavir Cmax and a one hour delay in tmax but the AUC was unchanged.
Slovenian: Metadon: V farmakokinetični študiji se je po sočasnem dajanju 600 mg abakavirja dvakrat dnevno z metadonom za 35 % zmanjšal abakavirjev Cmax in za eno uro podaljšal tmax , medtem ko je AUC ostal nespremenjen.
English: Adults, adolescents and children (weighing at least 25 kg):
Slovenian: Odrasli, mladostniki in otroci (ki tehtajo vsaj 25 kg):
English: Patients changing from the twice daily dosing regimen to the once daily dosing regimen should take the recomended once daily dose (as described above) approximately 12 hours after the last twice daily dose, and then continue to take the recomended once daily dose (as described above) approximately every 24 hours.
Slovenian: Bolniki, ki bodo prešli z režima odmerjanja dvakrat na dan na režim odmerjanja enkrat na dan, morajo vzeti priporočeni enkratni dnevni odmerek (kot je navedeno zgoraj) približno 12 ur po zadnjem odmerku režima odmerjanja dvakrat na dan in nato nadaljevati z jemanjem priporočenega enkratnega dnevnega odmerka (kot je navedeno zgoraj) približno vsakih 24 ur.
English: Other medicines and Ziagen Tell your doctor or pharmacist if you are taking any other medicines, or if you have taken any recently, including herbal medicines or other medicines you bought without a prescription.
Slovenian: Povejte zdravniku ali farmacevtu, če jemljete katera koli druga zdravila, ali ste jih pred kratkim jemali, vključno z zdravili rastlinskega izvora ali drugimi zdravili, ki ste jih kupili brez recepta.
English: CONTACT YOUR DOCTOR IMMEDIATELY for advice on whether you should stop taking Ziagen if: you get a skin rash OR you get one or more symptoms from at least TWO of the following groups
Slovenian: in se posvetujte glede prenehanja jemanja zdravila Ziagen, če: dobite kožni izpuščaj ALI opazite enega ali več simptomov iz najmanj DVEH od spodaj naštetih skupin
English: • fever (high temperature)
Slovenian: • povišana telesna temperatura (vročina),
English: Children (weighing less than 25 kg):
Slovenian: Otroci (ki tehtajo manj kot 25 kg):
English: Those reported in at least 10% of patients with a hypersensitivity reaction are in bold text.
Slovenian: Znaki in simptomi, o katerih so poročali pri vsaj 10 % bolnikov s preobčutljivostno reakcijo, so navedeni v krepkem tisku.
English: In adults moderately exposed to antiretroviral therapy the addition of abacavir to combination antiretroviral therapy provided modest benefits in reducing viral load (median change 0.44 log10 copies/ml at 16 weeks).
Slovenian: Pri bolnikih, ki so bili zmerno izpostavljeni protiretrovirusnem zdravljenju, je dodatek abakavirja k protiretrovirusni kombinaciji pokazal skromno prednost pri zmanjšanju virusne obremenitve (sprememba mediane 0,44 log10 kopij/ml pri 16 tednih).
English: When taken according to the dosage recommendations each 15 ml dose contains approximately 5 g of sorbitol.
Slovenian: Po priporočilih za odmerjanje vsebuje vsak odmerek 15 ml) 5 g sorbitola.
English: In controlled clinical studies laboratory abnormalities related to Ziagen treatment were uncommon, with no differences in incidence observed between Ziagen treated patients and the control arms.
Slovenian: V nadzorovanih kliničnih študijah so le redko opazili laboratorijske nenormalnosti, povezane z zdravilom Ziagen, pri čemer v incidenci med bolniki, zdravljenimi z zdravilom Ziagen, in kontrolnimi skupinami niso opazili razlik.
English: Animal studies have shown toxicity to the developing embryo and foetus in rats, but not in rabbits (see section 5.3).
Slovenian: Študije na živalih so pokazale toksičnost za razvijajoč se zarodek in plod pri podganah, toda ne pri kuncih (glejte poglavje 5.3).
English: Your doctor may need to monitor you while you are taking Ziagen.
Slovenian: Zdravnik vas bo morda moral med jemanjem zdravila Ziagen spremljati.
English: However, no effects on neuropsychological performance were seen when it was administered to patients with AIDS dementia complex.
Slovenian: Vendar pa niso zasledili nobenih nevropsiholoških motenj, kadar so ga dajali bolnikom obolelim z AIDS-om in demenco.
English: If abacavir is used in patients with mild hepatic impairment, then close monitoring is required, including monitoring of abacavir plasma levels if feasible (see sections 4.4 and 5.2).
Slovenian: Če se abakavir uporabi pri bolnikih z blago jetrno okvaro, je potreben skrben nadzor, vključno z nadziranjem plazemske vrednosti abakavirja, če je to izvedljivo (glejte poglavji 4.4 in 5.2).
English: You should have been tested for this gene before Ziagen was prescribed for you.
Slovenian: Testiranje za ta gen ste morali opraviti, preden vam je zdravnik predpisal zdravilo Ziagen.
English: Elderly No pharmacokinetic data are currently available in patients over 65 years of age.
Slovenian: Za bolnike nad 65. letom starosti trenutno nimamo farmakokinetičnih podatkov.
English: Some people taking Ziagen for HIV are more at risk of serious side effects.
Slovenian: Nekateri bolniki, ki jemljejo zdravilo Ziagen zaradi HIV, imajo večje tveganje resnih neželenih učinkov.
English: An oral solution (20 mg abacavir/ml) is also available for the treatment of children over three months of age and weighing less than 14 kg, or for people who need a lower than usual dose, or who cannot take tablets.
Slovenian: Za zdravljenje otrok, starejših od treh mesecev in s telesno maso, manjšo od 14 kg, ter za zdravljenje oseb, ki potrebujejo manjši odmerek od običajnega, ali ne morejo jemati tablet, je na voljo tudi peroralna raztopina (20 mg abakavirja/ml).
English: Appropriate use of abacavir can be guided using currently recommended resistance algorithms.
Slovenian: Za ustrezno uporabo abakavirja je potrebno upoštevati trenutno veljavne algoritme.
English: Children from three months to one year of age: The recommended dose is 8 mg/kg twice daily.
Slovenian: Otroci, od treh mesecev do enega leta starosti: Priporočeni odmerek je 8 mg/kg dvakrat na dan.
English: Pharmacotherapeutic group: nucleoside reverse transcriptase inhibitors, ATC Code: J05AF06
Slovenian: Farmakoterapevtska skupina: Nukleotidni in nukleozidni zaviralci reverzne transkriptaze, oznaka ATC: J05AF06
English: Following multiple oral doses of abacavir 300 mg twice a day there is no significant accumulation of abacavir.
Slovenian: 300 mg dvakrat dnevno se abakavir znatno ne akumulira.
English: Glaxo Operations UK Ltd (trading as Glaxo Wellcome Operations), Priory Street, Ware, Hertfordshire, SG 12 0DJ, United Kingdom.
Slovenian: Glaxo Operations UK Ltd (trading as Glaxo Wellcome Operations), Priory Street, Ware, Herts SG12 0DJ, Velika Britanija
English: The clinical relevance of this is unknown.
Slovenian: Klinična pomembnost tega ni znana.
English: Symptoms of infection and inflammation Old infections may flare up
Slovenian: Simptomi okužbe in vnetja Možnost ponovnega zagona starih okužb
English: Abacavir was not mutagenic in bacterial tests but showed activity in vitro in the human lymphocyte chromosome aberration assay, the mouse lymphoma assay, and the in vivo micronucleus test.
Slovenian: V bakterijskih testih abakavir ni bil mutagen, pokazala pa se je in vitro aktivnost v testu na kromosomske aberacije na človeških limfocitih, testu na mišjem limfomu ter v in vivo mikronukleusnem testu.
English: • Therapy experienced adults
Slovenian: • Predhodno že zdravljeni odrasli
English: Logistic regression modelling of the predictive value for genotype (adjusted for baseline plasma HIV-1 RNA [vRNA], CD4+ cell count, number and duration of prior antiretroviral therapies), showed that the presence of 3 or more NRTI resistance-associated mutations was associated with reduced response at Week 4 (p=0.015) or 4 or more mutations at median Week 24 (p≤0.012).
Slovenian: Model logistične regresije prediktivne vrednosti za genotip (prilagojeno na izhodiščno plazemsko vrednost HIV-1 RNA [vRNA], število CD4+ celic, število in trajanje predhodnih protiretrovirusnih zdravljenj) je pokazal, da je bila prisotnost 3 ali več mutacij, povezanih z odpornostjo proti NRTI, povezana z zmanjšanjem odziva v 4. tednu (p = 0,015), prisotnost 4 ali več mutacij pa v povprečju v 24. tednu (p ≤ 0,012).
English: Pancreatitis has been reported, but a causal relationship to abacavir treatment is uncertain.
Slovenian: Poročajo o primerih pankreatitisa, vendar vzročna povezava z zdravljenjem z abakavirjem ni dokazana.
English: The Ziagen pack includes an Alert Card, to remind you and medical staff about hypersensitivity reactions.
Slovenian: Škatlica zdravila Ziagen vsebuje opozorilno kartico, ki opozori vas in zdravniško osebje na preobčutljivostne reakcije.
English: If you have any further questions ask your doctor or pharmacist.
Slovenian: - Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom ali farmacevtom.
English: For many adverse reactions reported, it is unclear whether they are related to Ziagen, to the wide range of medicinal products used in the management of HIV infection or as a result of the disease process.
Slovenian: Za številne neželene učinke, o katerih so poročali, ni ugotovljeno, ali so povezani z zdravilom Ziagen ali z velikim številom zdravil, ki se uporabljajo za zdravljenje okužbe s HIV, ali pa so se pojavili kot posledica samega bolezenskega procesa.
English: Abacavir-resistant isolates of HIV-1 have been selected in vitro and are associated with specific genotypic changes in the reverse transcriptase (RT) codon region (codons M184V, K65R, L74V and Y115F).
Slovenian: Izolati HIV-1, rezistentni na abakavir, so bili izolirani in vitro in so povezani s specifičnimi genotipskimi spremembami v kodonskem območju (kodoni M184V, K65R, L74V in Y115F) reverzne transkriptaze (RT).
English: Very rare: erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis
Slovenian: Pogosti: izpuščaj (brez sistemskih simptomov) Zelo redki: multiformni eritem, Stevens-Johnsonov sindrom in toksična epidermalna nekroliza
English: Description of Selected Adverse Reactions
Slovenian: Opis izbranih neželenih učinkov
English: Metabolism and nutrition disorders Common: anorexia Very rare: lactic acidosis
Slovenian: Presnovne in prehranske motnje: Pogosti: anoreksija Zelo redki: laktacidoza
English: Check with your doctor if you think this applies to you.
Slovenian: Posvetujte se z vašim zdravnikom, če menite, da se to nanaša na vas.
English: Children weighing ≥ 20 kg to < 25 kg: The recommended dose is 450 mg daily.
Slovenian: Otroci, ki tehtajo ≥ 20 kg in <25 kg: Priporočeni odmerek je 450 mg dnevno.
English: If you are hypersensitive to Ziagen, return all your unused Ziagen oral solution for safe disposal.
Slovenian: Če ste preobčutljivi na zdravilo Ziagen, vrnite vso neporabljeno Ziagen peroralno raztopino, da se jo varno uniči.
English: Pull out the syringe plunger until the syringe contains the first part of your full dose Turn the bottle the right way up.
Slovenian: Izvlecite bat odmerne brizge dokler odmerne brizge ne napolnite s prvim delom vašega celotnega odmerka.
English: Based on the results of in vitro experiments and the known major metabolic pathways of abacavir, the potential for P450 mediated interactions with other medicinal products involving abacavir is low.
Slovenian: Na podlagi rezultatov in vitro preskušanj ter znanih glavnih presnovnih poti abakavirja obstaja le majhna verjetnost, da bo prišlo do s P450 povezanih interakcij z drugimi zdravili.
English: Ziagen is indicated in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infection in adults, adolescents and children (see sections 4.4 and
Slovenian: Zdravilo Ziagen je v kombinaciji z drugimi protiretrovirusnimi zdravili indicirano za zdravljenje odraslih, mladostnikov in otrok, okuženih z virusom HIV (Human Immunodefficiency Virus) (glejte poglavji 4.4 in 5.1).
English: ViiV Healthcare UK Limited Tel: + 44 (0)800 221441 customercontactuk@gsk.com
Slovenian: ViiV Healthcare UK Ltd Tel: + 44 (0)800 221441 customercontactuk@gsk.com
English: Abacavir is metabolised intracellularly to the active moiety, carbovir 5'- triphosphate (TP).
Slovenian: Abakavir se v celicah presnavlja v aktivno obliko, karbovir 5'-trifosfat (TP).
English: If you are hypersensitive to Ziagen, return all your unused Ziagen tablets for safe disposal.
Slovenian: Če ste preobčutljivi na zdravilo Ziagen, vrnite vse neporabljene tablete tega zdravila, da se varno uničijo.
English: • phenytoin, for treating epilepsy.
Slovenian: Med takšnimi so: • fenitoin za zdravljenje epilepsije;
English: Manufacturer: Glaxo Operations UK Ltd, (trading as GlaxoWellcome Operations) Harmire Road Barnard Castle Co. Durham DL12 8DT United Kingdom or ViiV Healthcare Trading Services UK Limited, 12 Riverwalk,
Slovenian: Izdelovalec: Glaxo Operations UK Ltd, (trading as GlaxoWellcome Operations) Harmire Road Barnard Castle Co. Durham DL12 8DT, Velika Britanija ali ViiV Healthcare Trading Services UK Limited, 12 Riverwalk, Citywest Business Campus, Dublin 24, Irska
English: Virological Response Based on Plasma HIV-1 RNA less than 80 copies/ml at Week 48 and Week 96 in the Once Daily versus Twice Daily abacavir + lamivudine randomisation of ARROW (Observed Analysis)
Slovenian: Virološki odziv glede na HIV-1 RNA v plazmi manj kot 80 kopij/ml, v 48. in 96. tednu pri randomizaciji jemanja abakavirja + lamivudina enkrat na dan v primerjavi z dvakrat na dan v preskušanju ARROW (analiza opaženih)
English: Studies in animals showed that abacavir had no effect on fertility (see section 5.3).
Slovenian: Plodnost Študije na živalih so pokazale, da abakavir ne vpliva na plodnost (glejte poglavje 5.3).
English: Twice daily (300 mg) administration:
Slovenian: Režim odmerjanja dvakrat na dan (300 mg):
English: Discard oral solution two months after first opening.
Slovenian: Peroralno raztopino zavrzite dva meseca po prvem odpiranju!
English: • difficulty moving
Slovenian: • oteženo gibanje.
English: The recommended dose is 8 mg/kg twice a day or 16 mg/kg once a day, up to a maximum total daily dose of 600 mg daily.
Slovenian: Priporočeni odmerek je 8 mg/kg dvakrat na dan ali 16 mg/kg do najvišjega skupnega odmerka 600 mg na dan.
English: Clinical description of abacavir HSR
Slovenian: Klinični opis HSR na abakavir
English: The tablet coating contains triacetin, methylhydroxypropylcellulose, titanium dioxide, polysorbate 80 and iron oxide yellow.
Slovenian: Obloga tablete vsebuje triacetin, hipromelozo, titanov dioksid, polisorbat 80 in rumeni železov oksid.