FrancophonIA/ELRC3.0 huggingface dataset:
English: For women taking oral oestrogens the starting dose is usually 3 mg injected once a week.
Slovenian: Za ženske, ki jemljejo peroralne estrogene, je začetni odmerek običajno 3 mg, injiciranih enkrat na teden.
English: The dosage of somatropin should be decreased in cases of persistent oedema or severe paraesthesia, in order to avoid the development of carpal tunnel syndrome.
Slovenian: Odmerjanje somatropina je treba zmanjšati v primerih vztrajnega edema ali hude parestezije, da se prepreči razvoj sindroma karpalnega kanala.
English: Adults with childhood-onset of GHD
Slovenian: Odrasli z začetkom GHD v otroštvu
English: For monitoring, the attainment of a normal peak bone mass defined as a T score > - 1 (i.e. standardised to average adult peak bone mass measured by dual energy X-ray absorptiometry taking into account gender and ethnicity) is one of the therapeutic objectives during the transition period.
Slovenian: Pri bolniku se spremlja doseg normalne največje kostne mase, opredeljene kot rezultat T > - 1 (tj. standardizirano na povprečno najvišjo kostno maso pri odraslih, izmerjeno z dvoenergijsko rentgensko absorpciometrijo ob upoštevanju spola in narodnosti), ki je en od terapevtskih ciljev v prehodnem obdobju.
English: There are no specific studies which address local tolerance in animals after subcutaneous injection, but data available from the repeated-dose toxicity studies revealed swelling and inflammatory infiltrate at the injection sites.
Slovenian: Specifičnih študij lokalnega prenašanja pri živalih po subkutani injekciji ni, vendar so podatki iz študij toksičnosti pri ponavljajočem se odmerjanju pokazali otekline in vnetne infiltrate na mestu injiciranja.
English: The treatment goal should be IGF-I concentrations within -0.5 and +1.5 SDS of the age corrected mean.
Slovenian: Cilj zdravljenja je doseči koncentracije IGF-I znotraj -0,5 in +1,5 SDS s starostno korekcijo srednje vrednosti.
English: In the children receiving Somatropin Biopartners a higher incidence of (non-serious) injection site reactions and a higher rate of formation of (non-neutralising) antibodies against somatropin as compared to children with daily administered recombinant growth hormone were observed (see also sections 4.4 and 4.8).
Slovenian: Pri otrocih, ki so prejemali zdravilo Somatropin Biopartners, so opazili višjo incidenco (ne-resnih) reakcij na mestu injiciranja in višjo pogostnost nastajanja (ne-nevtralizirajočih) protiteles proti somatropinu, kot pri otrocih, ki so dnevno prejemali rekombinantni rastni hormon (glejte tudi poglavji 4.4 in 4.8).
English: Slowly withdraw the required volume of solvent.
Slovenian: Počasi izvlecite potrebno količino vehikla.
English: In older or overweight patients, lower doses may be necessary.
Slovenian: Pri starejših bolnikih in bolnikih s prekomerno telesno težo bo morda potreben manjši začetni odmerek.
English: This gives your skin and the area under your skin time to recover from one injection before it gets another one in the same place.
Slovenian: S tem imata koža in del pod kožo čas, da okrevata od injiciranja, preden si zdravilo ponovno injicirate na istem mestu.
English: In paediatric patients there is no evidence that growth hormone replacement influences the recurrence rate or regrowth of intracranial neoplasms, but standard clinical practice requires regular pituitary imaging in patients with a history of pituitary pathology.
Slovenian: Pri pediatričnih bolnikih ni dokazov, zaradi katerih bi lahko sumili, da nadomeščanje rastnega hormona vpliva na stopnjo ponovitve ali ponovne rasti intrakranialnih novotvorb, vendar standardna klinična praksa pri bolnikih s patologijo hipofize v anamnezi zahteva redno slikanje hipofize.
English: You should not use Somatropin Biopartners if you are pregnant or are trying to become pregnant.
Slovenian: Zdravila Somatropin Biopartners ne uporabljajte, če ste noseči ali poskušate zanositi.
English: Prolonged overdose may result in a greater than normal growth of ears, nose, lips, tongue and cheekbone.
Slovenian: Če preveliko odmerjanje poteka daljše obdobje, lahko to povzroči večjo rast ušes, nosu, ustnic, jezika in ličnic, kot je normalno.
English: Diagnosis and therapy with this medicinal product should be initiated and monitored by physicians adequately experienced in the diagnosis and management of patients with GHD.
Slovenian: Diagnozo in zdravljenje s tem zdravilom morajo začeti in spremljati zdravniki, ki imajo ustrezne izkušnje pri diagnosticiranju in zdravljenju bolnikov z GHD.
English: After 6 months of weekly treatment with Somatropin Biopartners, there was a statistically significant reduction of 1.6 kg in fat mass in the Somatropin Biopartners group compared to the placebo group.
Slovenian: Po 6 mesecih tedenskega zdravljenja z zdravilom Somatropin Biopartners je prišlo do statistično značilnega 1,6-kilogramskega zmanjšanja maščobne mase v skupini, ki je prejemala zdravilo Somatropin Biopartners, v primerjavi s skupino s placebom.
English: Acute overdose could lead initially to hypoglycaemia and subsequently to hyperglycaemia.
Slovenian: Akutno preveliko odmerjanje lahko najprej povzroči hipoglikemijo, pozneje pa hiperglikemijo.
English: There have been reports of sleep apnoea and sudden death after initiating growth hormone therapy in patients with Prader-Willi syndrome, who had one or more of the following risk factors: severe obesity, history of upper airway obstruction or sleep apnoea, or unidentified respiratory infection.
Slovenian: Obstajajo poročila o apneji v spanju in nenadni smrti po uvedbi zdravljenja z rastnim hormonom pri bolnikih s Prader-Willijevim sindromom, ki so imeli enega ali več od naslednjih dejavnikov tveganja: huda debelost, obstrukcija zgornjih dihal ali apneja v spanju v anamnezi ali neidentificirana okužba dihal.
English: Infections and infestations Common: Herpes simplex
Slovenian: Infekcijske in parazitske bolezni pogosti: herpes simplex
English: - if you are being treated for more than one injury following a serious accident; - if you experience sudden serious breathing problems.
Slovenian: - če se zdravite zaradi več kot ene poškodbe po hudi nesreči.
English: The generation of such antibodies with low binding activity is unlikely to be clinically relevant.
Slovenian: Ni verjetno, da bi bilo nastajanje teh protiteles z nizko vezavno dejavnostjo klinično pomembno.
English: The apparent terminal half-life was about 7.4 h in children, presumably reflecting slow absorption from the site of injection.
Slovenian: Navidezni končni razpolovni čas je bil za otroke približno 7,4 ure, kar verjetno kaže na počasno absorpcijo z mesta injiciranja.
English: IGF-I SDS lower than -1
Slovenian: SDS IGF-I nižji kot -1
English: Doses in excess of human therapeutic doses have shown adverse effects on reproductive function in male and female rats and male dogs, possibly through disruption of hormonal regulation.
Slovenian: Odmerki, višji od terapevtskih odmerkov pri ljudeh, so pokazali neželene učinke na sposobnost razmnoževanja pri podganjih samcih in samicah in pasjih samcih, morda zaradi prekinitve reguliranja hormonov.
English: Long term carcinogenicity studies with Somatropin Biopartners have not been conducted.
Slovenian: Dolgoročnih študij kancerogenosti z zdravilom Somatropin Biopartners niso izvajali.
English: Clean the rubber stopper of both vials with an alcohol swab (figure 3b).
Slovenian: Gumijasti zamašek obeh vial očistite z alkoholno blazinico (slika 3b).
English: Preparing the suspension
Slovenian: Priprava suspenzije
English: Immune system disorders Common: Formation of antibodies against growth hormone
Slovenian: Bolezni imunskega sistema pogosti: nastanek protiteles proti rastnemu hormonu
English: Somatropin may induce insulin resistance.
Slovenian: Somatropin lahko povzroči rezistenco na insulin.
English: Adult-onset: Patients with GHD in adulthood are defined as patients with known hypothalamic-pituitary pathology and at least one additional known deficiency of a pituitary hormone excluding prolactin.
Slovenian: Začetek v odrasli dobi: Bolniki z GHD v odrasli dobi so opredeljeni kot bolniki z znano patologijo osi hipotalamus-hipofiza in z vsaj enim dodatno znanim pomanjkanjem hipofiznega hormona, ki ni prolaktin.
English: The solvent vial should be warmed to room temperature and the powder vial should be tapped and shaken to ensure the powder is moving freely.
Slovenian: Vialo z vehiklom je treba ogreti na sobno temperaturo, na vialo s praškom pa je treba potrkati in jo stresti, da se prašek prosto premika.
English: The tmax was later and the half-life longer following the administration of Somatropin Biopartners than when immediate release products had been previously administered once daily to the same subjects reflecting the slower and more prolonged release of hGH from the site of injection of Somatropin Biopartners.
Slovenian: tmax je bil kasnejši, razpolovni čas pa daljši po dajanju zdravila Somatropin Biopartners kot pri dajanju zdravil s takojšnjim sproščanjem, ki so jih prej dajali istim osebam enkrat na dan, kar kaže na počasnejše in podaljšano sproščanje hGH z mesta injiciranja zdravila Somatropin Biopartners.
English: - If you have an abnormal curving of the spine your doctor will monitor you for worsening of this
Slovenian: - Če imate nenormalno ukrivljeno hrbtenico, vas bo zdravnik spremljal, da se to stanje ne
English: Very limited data on exposure to other somatropin preparations during early pregnancy did not indicate an adverse pregnancy outcome.
Slovenian: Podatkov o uporabi tega zdravila pri nosečnicah ni. Zelo omejeni podatki o izpostavljenosti drugim pripravkom somatropina v zgodnji nosečnosti ne kažejo na neželene izide nosečnosti.
English: The apparent terminal half-life was about 16.8 h in adults, presumably reflecting slow absorption from the site of injection.
Slovenian: Navidezni končni razpolovni čas je bil za odrasle približno 16,8 ur, kar verjetno kaže na počasno absorpcijo z mesta injiciranja.
English: Apply gentle pressure to the injection site with a dry gauze or cotton pad.
Slovenian: Na mesto injiciranja nežno pritiskajte s suho gazo ali bombažnim kosmičem.
English: - oestrogen taken orally or other sex hormones - medicines to treat epilepsy - cyclosporine: a medicine to suppress the immune system
Slovenian: - peroralni estrogeni ali drugi spolni hormoni - zdravila za zdravljenje epilepsije - ciklosporin: zdravilo za zaviranje imunskega sistema ali zdravljenje drugih bolezni
English: Do not use any remaining solvent for a second preparation!
Slovenian: Preostalega vehikla ne uporabite za naslednjo pripravo zdravila!
English: Your doctor will check your levels of adrenal hormones (glucocorticoids) which may require adjustment once growth hormone therapy begins.
Slovenian: Vaš zdravnik bo preveril ravni hormonov nadledvične žleze (glukokortikoidov), ki jih bo morda treba prilagoditi, ko boste začeli zdravljenje z rastnim hormonom.
English: If growth hormone treatment is restarted, careful monitoring for symptoms of intracranial hypertension is necessary.
Slovenian: Če se zdravljenje z rastnim hormonom ponovno začne, je treba bolnika skrbno spremljati, da bi zaznali simptome intrakranialne hipertenzije.
English: The frequency of adverse reactions listed below is defined using the following convention: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000), not known (cannot be estimated from the available data):
Slovenian: Pogostnost neželenih učinkov je navedena po naslednjem dogovoru: Zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); neznana (ni mogoče oceniti iz razpoložljivih podatkov):
English: Injection site related reactions, mostly swelling at the injection site, were reported in approximately 43% of the paediatric patients.
Slovenian: Reakcije, povezane z mestom injiciranja, običajno oteklina na mestu injiciranja, so poročali pri približno 43 % pediatričnih bolnikov.
English: Because hGH may induce a state of insulin resistance, an adjustment of the insulin dose may be required.
Slovenian: hGH lahko povzroči odpornost na insulin, zato bo morda treba prilagoditi odmerek insulina.
English: This means that after preparation, the suspension is injected with a short needle into the fatty skin tissue.
Slovenian: To pomeni, da se pripravljena suspenzija s kratko iglo injicira v maščobno kožno tkivo.
English: The frequency of adverse reactions listed below is defined using the following convention: Very common (≥1/10); common (≥1/100 to <1/10); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data):
Slovenian: Pogostnost neželenih učinkov je navedena po naslednjem dogovoru: Zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov):
English: After the injection, wait a few seconds, then quickly withdraw the needle with the plunger still pushed down.
Slovenian: Po injiciranju počakajte nekaj sekund, nato pa iglo hitro izvlecite z batom pritisnjenim navzdol.
English: The recommended and maximum dose is 0.5 mg/kg/week and should not be exceeded.
Slovenian: Priporočeno in največje odmerjanje je 0,5 mg/kg enkrat na teden in ga ni dovoljeno prekoračiti.
English: Large doses of somatropin may impair glucose tolerance.
Slovenian: Visoki odmerki somatropina lahko okvarijo toleranco za glukozo.
English: The solvent is a clear, oily liquid.
Slovenian: Vehikel je bistra, oljna tekočina.
English: Slowly release the skin during the injection.
Slovenian: Med injiciranjem počasi spuščajte kožo.
English: It is unlikely that the antibody responses to treatment with Somatropin Biopartners are of clinical relevance.
Slovenian: Ni verjetno, da bi bil odziv protiteles na zdravljenje z zdravilom Somatropin Biopartners klinično pomemben.
English: The subcutaneous injection should always be administered at the same time of the day to increase compliance and the site of injection must be varied to prevent lipoatrophy.
Slovenian: Subkutano injiciranje je treba opraviti ob istem času dneva za povečanje skladnosti, mesto injiciranja pa je treba spreminjati, da se prepreči lipoatrofija.
English: If you are breast-feeding only use this medicine if your doctor indicates it is clearly necessary.
Slovenian: Če dojite, to zdravilo uporabite le, če zdravnik meni, da je to nujno potrebno.
English: There is an increased risk that paediatric patients with prior malignancies may develop second neoplasm when treated with growth hormone, especially if treatment of the primary malignancy involved radiotherapy.
Slovenian: Obstaja povečano tveganje, da se pri pediatričnih bolnikih pri uporabi rastnega hormona s predhodnimi malignostmi razvijejo sekundarne novotvorbe, zlasti če so se primarne malignosti zdravile tudi z radioterapijo.
English: If not used immediately, the suspension must be reconstituted again by swirling immediately before injection.
Slovenian: Če suspenzije ne uporabite takoj, jo morate tik pred injiciranjem rekonstituirati z vrtenjem.
English: If a drop of blood appears, maintain the pressure for a
Slovenian: Če se pojavi kapljica krvi, pritiskajte še nekaj trenutkov.
English: Dose (mg)
Slovenian: Odmerek (mg)
English: This medicine is used to treat adults with a lack (deficiency) of growth hormone who - already had growth hormone deficiency when they were children or - do not have enough growth hormone during adulthood.
Slovenian: To zdravilo se uporablja za odrasle s pomanjkanjem rastnega hormona, ki - so že imeli pomanjkanje rastnega hormona kot otroci ali - ki v odrasli dobi nimajo dovolj rastnega hormona.
English: Warm the solvent vial to room temperature by gently rolling it between your hands.
Slovenian: Vialo vehikla ogrejte na sobno temperaturo z nežnim valjanjem med dlanmi.
English: The powder should be homogenously suspended in the injection vehicle prior to administration.
Slovenian: Prašek mora biti homogeno suspendiran v vehiklu injekcije, preden jo uporabite.
English: When adverse reactions occurred, they tended to be transient and severity was generally mild to moderate.
Slovenian: Če so se pojavile neželene reakcije, so bile te prehodne, njihova resnost pa je bila v glavnem blaga do zmerna.
English: Important information about some of the ingredients of Somatropin Biopartners This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. it is essentially ‘sodium-free'.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Somatropin Biopartners To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni »brez natrija«.
English: The recommended dose is 0.5 mg of somatropin per kilogram of body weight injected once a week.
Slovenian: Priporočeni odmerek je 0,5 mg somatropina na kilogram telesne mase, injiciranega enkrat na teden.
English: In a randomized, parallel-group, multicentre Phase III study, 178 children between 3 and 12 years of age with organic and/or idiopathic GHD were randomised to receive either weekly administered Somatropin Biopartners (0.5 mg/kg/week) or daily administered recombinant hGH (0.03 mg/kg/day) for 12 months.
Slovenian: V randomizirani, vzporedni, multicentrični študiji faze III je bilo randomiziranih 178 otrok, starih 3 do 12 let z organskim in/ali idiopatičnim pomanjkanjem rastnega hormona, da so 12 mesecev tedensko prejemali zdravilo Somatropin Biopartners (0,5 mg/kg/teden) ali dnevno rekombinantni hGH (0,03 mg/kg/dan).
English: The patient or carer should receive training to ensure understanding of the administration procedure before being allowed to (self-) inject.
Slovenian: Bolnika ali negovalca je treba poučiti, kako naj (si) zdravilo (samo)injicirajo, in s tem zagotoviti, da razumejo postopek uporabe.
English: Non-clinical pharmacokinetic and pharmacodynamic studies in dogs and juvenile monkeys showed that Somatropin Biopartners released recombinant hGH in a prolonged manner and increased serum IGF-I for an extended period up to 5-6 days.
Slovenian: Predklinične farmakokinetične in farmakodinamične študije pri psih in mladih opicah so pokazale, da je zdravilo Somatropin Biopartners sproščalo rekombinantni hGH na podaljšan način in povečalo serumski IGF-I za podaljšano obdobje, ki je trajalo do 5-6 dni.
English: Withdraw the syringe and discard it.
Slovenian: Injekcijsko brizgo izvlecite in jo zavrzite.
English: Special populations
Slovenian: Posebne populacije Starejši ljudje
English: Side effects very commonly reported (may affect more than 1 in 10 people) were injection site swelling and development of substances (antibodies) in the blood that bind to growth hormone.
Slovenian: Neželeni učinki, o katerih so zelo pogosto poročali (pojavijo se lahko pri več kot 1 od 10 bolnikov), so oteklost na mestu injiciranja in razvoj snovi (protiteles) v krvi, ki vežejo rastni hormon.
English: The active substance is somatropin.
Slovenian: Zdravilna učinkovina je somatropin.
English: 3 mg (9 IU)
Slovenian: 3 mg (9 i.e.)
English: 2 mg (6 IU)
Slovenian: 2 mg (6 i.e.)
English: Common: Hypercortisolism (7.7%), hypothyroidism (2.2%), adrenal cortical insufficiency (3.3%), hypothyreosis secondary to TSH deficiency (2.6%), decreased free thyroxine (4.4%), increased blood TSH (2.2%)
Slovenian: Bolezni endokrinega sistema pogosti: hiperkortizolizem (7,7 %), hipotiroidizem (2,2 %), adrenalnokortikalna insuficienca (3,3 %), hipotireoza kot posledica pomanjkanja TSH (2,6 %), zmanjšanje vrednosti prostega tiroksina (4,4 %), povečanje vrednosti TSH v krvi (2,2 %)
English: None or -0.5 mg (all patients)
Slovenian: kliničnega statusa brez ali -0,5 mg (vsi bolniki)
English: The recommended starting dose is 2 mg of somatropin injected once a week.
Slovenian: Priporočeni začetni odmerek je 2 mg somatropina, injiciranega enkrat na teden.
English: CONDITIONS OR RESTRICTIONS REGARDING SUPPLY
Slovenian: B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE
English: For children heavier than 40 kg, two vials (a 10 mg and a 20 mg vial or two vials of 20 mg) can be used according to the body weight as indicated in the table below.
Slovenian: Za otroke s telesno maso več kot 40 kg lahko uporabite dve viali (vialo z 10 mg in vialo z 20 mg ali dve viali z 20 mg) v skladu s telesno maso, kot je razvidno v spodnji preglednici.
English: The maximum injection volume per injection site should not exceed 1 mL.
Slovenian: Največja količina injiciranega zdravila na mesto injiciranja ne sme preseči 1 ml.
English: After accidental intramuscular injection, hypoglycaemia may occur.
Slovenian: Po nehotnem intramuskularnem injiciranju se lahko pojavi hipoglikemija.
English: It is therefore crucial to assess baseline and stress doses of glucocorticoids which may need to be adjusted when growth hormone therapy is initiated.
Slovenian: Zato je ključnega pomena, da se ocenijo izhodiščni in stresni odmerki glukokortikoidov, ki jih bo morda treba po uvedbi zdravljenja z rastnim hormonom prilagoditi.
English: Somatropin Biopartners has given rise to the formation of antibodies in approximately 4% of adult patients.
Slovenian: Zdravilo Somatropin Biopartners je povzročilo razvoj protiteles pri približno 4 % odraslih bolnikov.
English: Long-term therapy in growth hormone-deficient patients increases bone mineral density.
Slovenian: Dolgotrajno zdravljenje pri bolnikih s pomanjkanjem rastnega hormona zveča mineralno gostoto kosti.
English: The somatropin in this medicinal product is a polypeptide hormone of recombinant DNA origin.
Slovenian: Somatropin v tem zdravilu je polipeptidni hormon, pridelan z metodo rekombinantne DNA.
English: Somatropin therapy has a beneficial effect on body composition in patients with -GHD, in that body fat stores are reduced and lean body mass is increased.
Slovenian: Zdravljenje s somatropinom ima koristen učinek na zgradbo telesa pri bolnikih z GHD, in sicer tako, da se zmanjšajo zaloge maščob v telesu, zveča pa se delež puste telesne mase.
English: • Somatropin treatment must not be started in patients with acute critical illness due to complications following open heart or abdominal surgery, multiple accidental trauma, or to patients having acute respiratory failure or similar conditions.
Slovenian: • S Somatropinom se ne sme zdraviti bolnikov z akutno kritično boleznijo, nastalo zaradi zapletov po operaciji na odprtem srcu ali v trebuhu, bolnikov z večkratnimi nezgodnimi poškodbami ter bolnikov z akutno odpovedjo dihanja ali podobnimi stanji.
English: After reconstitution the injection should be administered immediately.
Slovenian: Po rekonstituciji je treba injekcijo dati takoj.
English: This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. it is essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni »brez natrija«.
English: Thyroid function should therefore be closely monitored in all patients.
Slovenian: Zato je treba pri vseh bolnikih natančno spremljati delovanje ščitnice.
English: What Somatropin Biopartners is and what it is used for What you need to know before you use Somatropin Biopartners
Slovenian: Kaj je zdravilo Somatropin Biopartners in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Somatropin Biopartners Kako uporabljati zdravilo Somatropin Biopartners
English: Somatropin has no or negligible influence on the ability to drive and use machines.
Slovenian: Somatropin nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: Patients with diabetes, glucose intolerance, or additional risk factors for diabetes should be monitored closely during somatropin therapy.
Slovenian: Bolnike s sladkorno boleznijo, neprenašanjem glukoze ali dodatnimi dejavniki tveganja za sladkorno bolezen je treba med zdravljenjem s somatropinom skrbno spremljati.
English: Once a normal peak bone mass is attained patients should be switched to Somatropin Biopartners for adults, if clinically indicated, and the dosing recommendation for adults should be followed.
Slovenian: Ko je dosežena največja kostna masa, mora bolnik preiti na zdravljenje z zdravilom Somatropin Biopartners za odrasle, če je to klinično indicirano, upoštevati pa je treba smernice glede odmerjanja pri odraslih.