FrancophonIA/ELRC3.0 huggingface dataset:
English: There is no specific antidote for overdose with semaglutide.
Croatian: Nema specifičnog protuotrova za predoziranje semaglutidom.
English: If necessary you can change the day of your weekly injection of this medicine as long as it has been at least 3 days since your last injection of it. After selecting a new dosing day, continue with once a week dosing.
Croatian: Po potrebi možete promijeniti dan za davanje tjedne injekcije ovog lijeka ako je prošlo najmanje 3 dana od posljednje injekcije.
English: In addition, semaglutide treatment increased fasting insulin concentrations compared to placebo.
Croatian: Osim toga, liječenje semaglutidom povisilo je koncentracije inzulina natašte u usporedbi s placebom.
English: Prior to excretion, semaglutide is extensively metabolised through proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain.
Croatian: Prije izlučivanja semaglutid se u velikoj mjeri metabolizira proteolitičkom razgradnjom peptidne veze i sekvencijalnom beta oksidacijom bočnog lanca masnih kiselina.
English: No dose adjustment of paracetamol is necessary when administered with semaglutide.
Croatian: Nije potrebno prilagođavanje doze paracetamola kad se primjenjuje sa semaglutidom.
English: Semaglutide caused marked reductions in maternal body weight and reductions in embryonic survival and growth.
Croatian: Semaglutid je uzrokovao značajna smanjenja tjelesne težine majke i smanjenje preživljenja i rasta embrija.
English: Women of childbearing potential are recommended to use contraception when treated with semaglutide.
Croatian: Ženama reproduktivne dobi preporučuje se korištenje kontracepcije tijekom liječenja semaglutidom.
English: • After four weeks your doctor will increase your dose to 0.5 mg once a week.
Croatian: • Nakon četiri tjedna liječnik će Vam povećati dozu na 0,5 mg jedanput na tjedan.
English: Exenatide ER 2 mg
Croatian: Eksenatid ER 2 mg
English: Renal impairment did not impact the pharmacokinetics of semaglutide in a clinically relevant manner.
Croatian: Oštećenje bubrega nije utjecalo na farmakokinetiku semaglutida na klinički značajan način.
English: *human glucagon-like peptide-1 (GLP-1) analogue produced in Saccharomyces cerevisiae cells by recombinant DNA technology.
Croatian: *Analog humanog glukagonu sličnog peptida-1 (GLP-1) proizveden tehnologijom rekombinantne
English: If you use more Ozempic than you should
Croatian: Ako primijenite više lijeka Ozempic nego što ste trebali
English: In this trial, adjudicated events of diabetic retinopathy complications occurred in more patients treated with semaglutide (3.0%) compared to placebo (1.8%).
Croatian: Tijekom ovog ispitivanja presudne komplikacije dijabetičke retinopatije pojavile su se u više bolesnika liječenih semaglutidom (3,0%) u usporedbi s placebom (1,8%).
English: If you do that, you might not get the intended effect of this medicine.
Croatian: Ako to učinite, lijek možda neće imati željeni učinak.
English: NovoFine Plus needles are included in the package.
Croatian: U pakiranju su priložene igle NovoFine Plus.
English: There were 2,358 patients with normal or mild renal impairment, 832 with moderate and 107 with severe or end stage renal impairment.
Croatian: 2358 bolesnika imalo je normalnu funkciju bubrega ili blago oštećenje funkcije bubrega, 832 umjereno, a 107 teško oštećenje funkcije bubrega ili oštećenje bubrega u završnoj fazi.
English: The risk reduction in the primary composite outcome was mainly driven by decreases in the rate of non-fatal stroke (39%) and non-fatal myocardial infarction (26%) (figure 3).
Croatian: Smanjenje rizika primarnog kompozitnog ishoda uglavnom je nastalo zbog smanjenja stope moždanih udara bez smrtnog ishoda (39%) i smanjenja infarkta miokarda bez smrtnog ishoda (26%) (slika 3).
English: Semaglutide is not anticipated to decrease the effect of oral contraceptives as semaglutide did not change the overall exposure of ethinylestradiol and levonorgestrel to a clinically relevant degree when an oral contraceptive combination medicinal product (0.03 mg ethinylestradiol/0.15 mg levonorgestrel) was co-administered with semaglutide.
Croatian: Ne očekuje se da će semaglutid smanjiti učinak oralnih kontraceptiva jer nije promijenio ukupnu izloženost etinilestradiola i levonorgestrela u klinički značajnoj mjeri pri istodobnoj primjeni kombiniranog oralnog kontraceptiva (0,03 mg etinilestradiola/0,15 mg levonorgestrela) i semaglutida.
English: EXP Discard pen 6 weeks after first use.
Croatian: EXP 6 tjedana nakon prve primjene brizgalicu bacite u otpad.
English: Table 1 lists adverse reactions identified in all phase 3a trials in patients with type 2 diabetes mellitus (further described in section 5.1).
Croatian: U tablici 1 navode se nuspojave utvrđene u svim ispitivanjima faze 3a u bolesnika sa šećernom bolešću tipa 2 (dodatno opisano u dijelu 5.1).
English: In addition, semaglutide reduces the preference for high fat foods.
Croatian: Osim toga, semaglutid smanjuje želju za masnom hranom.
English: If the dose counter stops before 1 mg, there is not enough solution left for a full dose of 1 mg.
Croatian: Ako se izbornik doze zaustavi prije 1 mg, to znači da nije ostalo dovoljno otopine za cijelu dozu od 1 mg.
English: This was observed in insulin-treated patients with known diabetic retinopathy.
Croatian: To je zabilježeno u bolesnika liječenih inzulinom s poznatom dijabetičkom retinopatijom.
English: Semaglutide did not change the overall exposure or Cmax of metformin following dosing of 500 mg twice daily over 3.5 days.
Croatian: Semaglutid nije promijenio ukupnu izloženost ili Cmax metformina nakon primjene doze od 500 mg dvaput dnevno tijekom 3,5 dana.
English: Exposure of ethinylestradiol was not affected; an increase of 20% was observed for levonorgestrel exposure at steady state.
Croatian: Nije bilo utjecaja na izloženost etinilestradiolu; izloženost levonorgestrelu povećana je za 20% u stanju dinamičke ravnoteže.
English: The frequencies of the adverse reactions are based on a pool of the phase 3a trials excluding the cardiovascular outcomes trial (see text below the table for additional details).
Croatian: Učestalosti nuspojava temelje se na skupini ispitivanja faze 3a, isključujući ispitivanje kardiovaskularnih ishoda (dodatne pojedinosti potražite u tekstu ispod tablice).
English: • injection site reactions - such as bruising, pain, irritation, itching and rash.
Croatian: • reakcije na mjestu injiciranja - kao što su modrice, bol, nadraženost, svrbež i osip.
English: This should be considered when treating patients, with impaired renal function as nausea, vomiting, and diarrhoea may cause dehydration which could cause a deterioration of renal function (see section 4.8).
Croatian: To je potrebno uzeti u obzir pri liječenju bolesnika s oštećenjem bubrega jer mučnina, povraćanje ili dijareja mogu uzrokovati dehidraciju koja može dovesti do pogoršanja bubrežne funkcije (vidjeti dio 4.8).
English: Fasting and postprandial lipids
Croatian: Lipidi natašte i postprandijalno
English: Intent-to-Treat (ITT) Population(N)
Croatian: intent-to-treat, ITT) (N)
English: Significant reductions in mean systolic blood pressure were observed when Ozempic 0.5 mg (3.5-5.1 mmHg) and 1 mg (5.4-7.3 mmHg) were used in combination with oral antidiabetic medicinal products or basal insulin.
Croatian: Značajna smanjenja srednjeg sistoličkog krvnog tlaka su zabilježena pri primjeni lijeka Ozempic 0,5 mg (3,5-5,1 mmHg) i 1 mg (5,4-7,3 mmHg) u kombinaciji s oralnim antidijabetičkim lijekovima ili bazalnim inzulinom.
English: The cartridge is assembled into a disposable pre-filled pen made of polypropylene, polyoxymethylene, polycarbonate and acrylonitrile butadiene styrene.
Croatian: Uložak se nalazi u jednokratnoj, napunjenoj brizgalici od polipropilena, polioksimetilena, polikarbonata i akrilonitril butadien stirena.
English: Caution should be exercised when treating these patients with semaglutide (see section 5.2).
Croatian: Potreban je oprez kod liječenja tih bolesnika semaglutidom (vidjeti dio 5.2).
English: If this happens you might not get the intended effect of this medicine.
Croatian: Ako se to dogodi, lijek možda neće imati željeni učinak.
English: Severe hypoglycaemia was primarily observed when semaglutide was used with a sulfonylurea (1.2% of subjects, 0.03 events/patient year) or insulin (1.5% of subjects, 0.02 events/patient year).
Croatian: Teška hipoglikemija prije svega je zabilježena pri primjeni semaglutida sa sulfonilurejom (1,2% ispitanika, 0,03 događaja/bolesnik-godini) ili inzulinom (1,5% ispitanika, 0,02 događaja/bolesnik-godini).
English: In animal studies, semaglutide attenuates the development of atherosclerosis by preventing aortic plaque progression and reducing inflammation in the plaque.
Croatian: U ispitivanjima na životinjama semaglutid ublažava razvoj ateroskleroze sprječavanjem progresije plaka aorte i smanjenjem upale u plaku.
English: After selecting a new dosing day, once-weekly dosing should be continued.
Croatian: Nakon odabira novog dana za doziranje potrebno je nastaviti s doziranjem jedanput na tjedan.
English: • Do not wash, soak or lubricate your pen.
Croatian: • Nemojte prati, namakati niti podmazivati svoju brizgalicu.
English: • The active substance is semaglutide.
Croatian: • Djelatna tvar je semaglutid.
English: Semaglutide should be used with caution in patients receiving oral medicinal products that require rapid gastrointestinal absorption.
Croatian: Potreban je oprez pri primjeni semaglutida u bolesnika koji uzimaju peroralne lijekove koji zahtijevaju brzu gastrointestinalnu apsorpciju.
English: Furthermore, semaglutide is stabilised against degradation by the DPP-4 enzyme.
Croatian: Osim toga, razgradnju semaglutida stabilizira enzim DPP-4.
English: The patient should be advised to discard the injection needle after each injection and store the pen without an injection needle attached.
Croatian: Bolesnika treba savjetovati da nakon svakog injiciranja iglu za injekciju zbrine, a brizgalicu spremi bez pričvršćene igle.
English: Self-monitoring of blood glucose is not needed in order to adjust the dose of Ozempic.
Croatian: Nije potrebno samopraćenje glukoze u krvi radi prilagođavanja doze lijeka Ozempic.
English: Nausea occurred in 17.0% and 19.9% of patients when treated with semaglutide 0.5 mg and 1 mg, respectively, diarrhoea in 12.2% and 13.3% and vomiting in 6.4% and 8.4%.
Croatian: Mučnina se pojavila u 17,0% i 19,9% bolesnika liječenih semaglutidom 0,5 mg odnosno 1 mg, proljev u 12,2% i 13,3%, a povraćanje u 6,4% i 8,4%.
English: Frequency based on cardiovascular outcomes trial.
Croatian: Učestalost utemeljena na ispitivanju kardiovaskularnih ishoda.
English: In female rats, an increase in oestrous cycle length and a small reduction in corpora lutea (ovulations) were observed at doses associated with maternal body weight loss.
Croatian: U ženki štakora zabilježeno je produljenje estrusa i malo smanjenje corpora lutea (ovulacija) pri dozama povezanim s gubitkom tjelesne težine majke.
English: In SUSTAIN 6 (see subsection Cardiovascular disease) 867 patients were on premix insulin (with or without OAD(s)) at baseline.
Croatian: U ispitivanju SUSTAIN 6 (vidjeti odlomak Kardiovaskularne bolesti) 867 bolesnika primalo je predmiješani inzulin (s oralnim antidijabetikom ili bez njega) na početku.
English: Before first use: Store in a refrigerator (2°C to 8°C).
Croatian: Prije prve primjene: Čuvati u hladnjaku (2°C do 8°C).
English: In 2-year carcinogenicity studies in rats and mice, semaglutide caused thyroid C-cell tumours at clinically relevant exposures.
Croatian: U 2-godišnjim ispitivanjima kancerogenosti u štakora i miševa semaglutid je uzrokovao tumore C-stanica štitnjače pri klinički značajnim izlaganjima.
English: The pen is designed to be used with NovoFine or NovoTwist disposable needles.
Croatian: Brizgalica je namijenjena za uporabu s jednokratnim iglama NovoFine ili NovoTwist.
English: In cardiovascular high risk population the adverse reaction profile was similar to that seen in the other phase 3a trials (described in section 5.1).
Croatian: Dvogodišnje ispitivanje kardiovaskularnih ishoda i sigurnosti Kod populacije s visokim kardiovaskularnim rizikom profil nuspojava bio je sličan onom zabilježenom u drugim ispitivanjima faze 3a (opisanima u dijelu 5.1).
English: In developmental toxicity studies in rabbits and cynomolgus monkeys, increased pregnancy loss and slightly increased incidence of foetal abnormalities were observed at clinically relevant exposures.
Croatian: U ispitivanjima razvojne toksičnosti u kunića i makaki majmuna zabilježen je povećani broj prekida trudnoće i malo povećana incidencija fetalnih abnormalnosti pri klinički značajnim izlaganjima.
English: This was shown with a single dose of 0.5 mg semaglutide for patients with different degrees of renal impairment (mild, moderate, severe or patients in dialysis) compared with subjects with normal renal function.
Croatian: To je pokazala jedna doza od 0,5 mg semaglutida za bolesnike s različitim stupnjevima oštećenja bubrega (blago, umjereno, teško ili bolesnici na dijalizi) u usporedbi s ispitanicima s normalnom bubrežnom funkcijom.
English: Check the flow
Croatian: Provjerite protok
English: 1.5 ml or 3 ml glass cartridge (type I glass) closed at the one end with a rubber plunger (chlorobutyl) and at the other end with an aluminium cap with a laminated rubber sheet (bromobutyl/polyisoprene) inserted.
Croatian: Stakleni uložak od 1,5 ml ili 3 ml (staklo tipa 1) zatvoren s jedne strane gumenim klipom (klorobutil) i aluminijskim zatvaračem s umetnutim pokrovom od laminirane gume (bromobutil/poliizopren).
English: Ozempic is given as an injection under the skin (subcutaneous injection).
Croatian: Ozempic se primjenjuje potkožnom (supkutanom) injekcijom.
English: The reactions are listed below by system organ class and absolute frequency.
Croatian: Nuspojave su navedene u nastavku prema klasifikaciji organskih sustava i apsolutnoj učestalosti.
English: Semaglutide did not prolong QTc intervals at supra-therapeutic dose levels (up to 1.5 mg at steady state).
Croatian: Semaglutid nije produljio QTc intervale pri supraterapeutskim razinama doze (do 1,5 mg u stanju dinamičke ravnoteže).
English: Semaglutide did not affect male fertility in rats.
Croatian: Semaglutid nije utjecao na plodnost mužjaka u štakora.
English: In embryo-foetal development studies in rats, semaglutide caused embryotoxicity below clinically relevant exposures.
Croatian: U ispitivanjima embrio-fetalnog razvoja u štakora, semaglutid je uzrokovao embriotoksičnost ispod klinički značajnih izlaganja.
English: If the dose counter stops before 0.5 mg, there is not enough solution left for a full dose of 0.5 mg.
Croatian: Ako se izbornik doze zaustavi prije 0,5 mg, to znači da nije ostalo dovoljno otopine za cijelu dozu od 0,5 mg.
English: When the pen is empty, throw it away without a needle on as instructed by your doctor, nurse, pharmacist or local authorities.
Croatian: Kada je brizgalica prazna, bacite je u otpad bez nataknute igle, sukladno uputama Vašeg liječnika, medicinske sestre, ljekarnika ili u skladu s lokalnim propisima.
English: The incidence of discontinuation of treatment due to adverse events was 6.1% and 8.7% for patients treated with semaglutide 0.5 mg and 1 mg, respectively, versus 1.5% for placebo.
Croatian: Incidencija prekida liječenja zbog štetnih događaja bila je 6,1% i 8,7% u bolesnika liječenih semaglutidom 0,5 mg odnosno 1 mg, naspram 1,5% za placebo.
English: Combination with sulfonylurea monotherapy
Croatian: Kombinacija s monoterapijom sulfonilurejom
English: Injection site reactions (e.g. injection site rash, erythema) have been reported by 0.6% and 0.5% of patients receiving semaglutide 0.5 mg and 1 mg, respectively.
Croatian: Reakcije na mjestu injiciranja (npr. osip na mjestu injiciranja, eritem) prijavilo je 0,6% i 0,5% bolesnika koji su primali semaglutid 0,5 mg odnosno 1 mg.
English: Patients treated with semaglutide in combination with a sulfonylurea or insulin may have an increased risk of hypoglycaemia.
Croatian: U bolesnika liječenih semaglutidom u kombinaciji sa sulfonilurejom ili inzulinom moguć je povećani rizik od hipoglikemije.
English: Abdominal pain Abdominal distension Constipation Dyspepsia Gastritis
Croatian: Povraćanje Bol u abdomenu Distenzija abdomena Konstipacija Dispepsija Gastritis
English: • The best places to give the injection are the front of your thighs, the front of your waist
Croatian: • Najbolja mjesta za davanje injekcije su prednja strana bedara, područje trbuha (abdomen) ili nadlaktica.
English: The risk of hypoglycaemia can be lowered by reducing the dose of sulfonylurea or insulin when initiating treatment with semaglutide (see section 4.8).
Croatian: Rizik od hipoglikemije može se smanjiti smanjenjem doze sulfonilureje ili inzulina na početku liječenja semaglutidom (vidjeti dio 4.8).
English: If you use this medicine in combination with a sulphonylurea or insulin, low blood sugar (hypoglycaemia) may occur which may reduce your ability to concentrate.
Croatian: Ako primjenjujete ovaj lijek u kombinaciji sa sulfonilurejom ili inzulinom, može doći do pojave niskog šećera u krvi (hipoglikemije), što može smanjiti Vašu sposobnost koncentracije.
English: • less appetite
Croatian: • smanjeni apetit
English: Sodium content This medicine contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially ‘sodium-free'.
Croatian: Sadržaj natrija Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po dozi, tj. zanemarive količine natrija.
English: In SUSTAIN 6 (see subsection Cardiovascular disease) 123 patients were on sulfonylurea monotherapy at baseline.
Croatian: U ispitivanju SUSTAIN 6 (vidjeti odlomak Kardiovaskularne bolesti) 123 bolesnika primala su monoterapiju sulfonilurejom na početku.
English: What Ozempic looks like and contents of the pack Ozempic is a clear and colourless or almost colourless solution for injection in a pre-filled pen.
Croatian: Ozempic je bistra i bezbojna ili gotovo bezbojna otopina za injekciju u napunjenoj brizgalici.
English: Paediatric population Semaglutide has not been studied in paediatric patients.
Croatian: Semaglutid nije ispitivan u pedijatrijskih bolesnika.
English: Dulaglutide 1.5 mg
Croatian: Dulaglutid 1,5 mg
English: Non-lethal thyroid C-cell tumours observed in rodents are a class effect for GLP-1 receptor agonists.
Croatian: Nesmrtonosni tumori C-stanica štitnjače u glodavaca predstavljaju učinak skupine za agoniste receptora GLP-1.
English: The starting dose is 0.25 mg semaglutide once weekly.
Croatian: Početna doza je 0,25 mg semaglutida jedanput na tjedan.
English: • The other ingredients are: disodium phosphate dihydrate, propylene glycol, phenol, water for injections, sodium hydroxide/hydrochloric acid (for pH adjustment).
Croatian: • Drugi sastojci su: natrijev hidrogenfosfat dihidrat, propilenglikol, fenol, voda za injekcije, natrijev hidroksid/kloridna kiselina (za podešavanje pH).
English: If you have diabetic eye disease and are using insulin, this medicine may lead to a worsening of your vision, and this may require treatment.
Croatian: Bolest oka uzrokovana šećernom bolešću (retinopatija) Ako imate bolest oka uzrokovanu šećernom bolešću i primijenjujete inzulin, ovaj lijek može dovesti do pogoršanja vida, te može zahtijevati liječenje.
English: Dulaglutide 0.75 mg
Croatian: Dulaglutid 0,75 mg
English: MARKETING AUTHORISATION NUMBERS EU/1/17/1251/002
Croatian: 12. BROJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/17/1251/002
English: Semaglutide compared to placebo lowered fasting triglyceride and very low density lipoproteins (VLDL) cholesterol concentrations by 12% and 21%, respectively.
Croatian: Semaglutid u usporedbi s placebom snizio je koncentracije triglicerida i lipoproteina vrlo niske gustoće (VLDL) natašte za 12% odnosno 21%.
English: If you forget to use Ozempic
Croatian: Ako ste zaboravili primijeniti Ozempic
English: In-use shelf life: 6 weeks.
Croatian: Rok valjanosti nakon otvaranja: 6 tjedana.
English: Beta-cell function and insulin secretion
Croatian: Funkcija beta stanica i lučenje inzulina
English: Ozempic pre-filled pen and needle (example)
Croatian: Ozempic napunjena brizgalica i igla (primjer)
English: Time since randomisation (week) Ozempic 0.5 mg
Croatian: Vrijeme od randomizacije (u tjednima) Ozempic 0,5 mg
English: In patients with type 2 diabetes, the mean steady state concentrations following subcutaneous administration of 0.5 mg and 1 mg semaglutide were approximately 16 nmol/L and 30 nmol/L, respectively.
Croatian: U bolesnika sa šećernom bolešću tipa 2 srednje koncentracije u stanju dinamičke ravnoteže nakon supkutane primjene semaglutida od 0,5 mg i 1 mg bile su približno 16 nmol/l, odnosno 30 nmol/l.
English: Experience with the use of Semaglutide in patients with severe hepatic impairment is limited.
Croatian: Iskustvo s primjenom semaglutida u bolesnika s teškim oštećenjem jetre je ograničeno.
English: No dose adjustment is required based on age.
Croatian: Nije potrebno prilagođavanje doze prema dobi.
English: In patients with type 2 diabetes, semaglutide resulted in the following relative reductions in glucagon compared to placebo: fasting glucagon (8-21%), postprandial glucagon response (14-15%) and mean 24 hour glucagon concentration (12%).
Croatian: U bolesnika sa šećernom bolešću tipa 2 primjena semaglutida rezultirala je sljedećim relativnim smanjenjem glukagona u usporedbi s placebom: glukagon natašte (8-21%), postprandijalni odgovor glukagona (14-15%) i srednja vrijednost koncentracija glukagona tijekom 24 sata (12%).
English: • inflamed stomach (‘gastritis') - the signs include stomach ache, feeling sick (nausea) or being sick (vomiting)
Croatian: • upala želuca (gastritis) - znakovi uključuju bol u želucu, mučninu ili povraćanje
English: In a long-term trial in subjects with cardiovascular risk factors, 16% of Ozempic-treated subjects had an increase in heart rate of >10 bpm compared to 11% of subjects on placebo after 2 years of treatment.
Croatian: U dugotrajnim ispitivanjima u ispitanika s kardiovaskularnim faktorima rizika nakon 2 godine liječenja, 16% ispitanika liječenih lijekom Ozempic imalo je porast srčane frekvencije za ˃10 bpm u usporedbi s 11% ispitanika liječenih placebom.
English: Semaglutide did not change the overall exposure or Cmax of R- and S-warfarin following a single dose of warfarin (25 mg), and the pharmacodynamic effects of warfarin as measured by the international normalised ratio (INR) were not affected in a clinically relevant manner.
Croatian: Semaglutid nije promijenio ukupnu izloženost ili Cmax R- i S-varfarina nakon primjene jedne doze varfarina (25 mg) i nije bilo klinički značajnog utjecaja na farmakodinamičke učinke varfarina izmjerene međunarodnim normaliziranim omjerom (engl.
English: Figure 3 Kaplan-Meier plot of time to first occurrence of the composite outcome: cardiovascular death, non-fatal myocardial infarction or non-fatal stroke (SUSTAIN 6)
Croatian: Slika 3 Kaplan-Meierova krivulja vremena do prve pojave kompozitnog ishoda: smrti uzrokovane kardiovaskularnim događajem, infarkta miokarda bez smrtnog ishoda ili moždanog udara bez smrtnog ishoda (SUSTAIN 6)
English: In juvenile rats, semaglutide caused delayed sexual maturation in both males and females.
Croatian: U mladih štakora semaglutid je uzrokovao kasnije seksualno sazrijevanje u mužjaka i ženki.
English: Caution should be exercised when using semaglutide in patients with diabetic retinopathy treated with insulin.
Croatian: Potreban je oprez pri primjeni semaglutida u bolesnika s dijabetičkom retinopatijom liječenih inzulinom.
English: Overdoses of up to 4 mg in a single dose, and up to 4 mg in a week have been reported in clinical trials.
Croatian: U kliničkim ispitivanjima prijavljena su predoziranja do 4 mg u jednoj dozi i do 4 mg u tjedan dana.
English: In a 56-week open-label trial, 813 patients on metformin alone (49%), metformin with sulfonylurea (45%) or other (6%) were randomised to Ozempic 1 mg or exenatide ER 2 mg once weekly.
Croatian: U 56-tjednom otvorenom ispitivanju, 813 bolesnika samo na metforminu (49%), na metforminu sa sulfonilurejom (45%) i ostali (6%) randomizirani su na Ozempic 1 mg ili eksenatid ER 2 mg jedanput na tjedan.