FrancophonIA/ELRC3.0 huggingface dataset:
English: • Personal history of myopathy and/or rhabdomyolysis with statins and/or fibrates or confirmed creatine phosphokinase elevation above 5 times the upper limit of normal (ULN) under previous statin treatment (see section 4.4)
Slovenian: • Osebna anamneza miopatije in/ali rabdomiolize pri jemanju statinov in/ali fibratov ali potrjeno zvišanje ravni kreatin-fosfokinaze nad 5-kratnik zgornje normalne meje (ULN) pri prejšnjem zdravljenju s statini (glejte poglavje 4.4)
English: Concomitant intake of large quantities (over 1 liter daily) of grapefruit juice and simvastatin resulted in a 7-fold increase in plasma exposure to simvastatin acid.
Slovenian: Sočasen vnos velikih količin grenivkinega soka (več kot 1 liter dnevno) in simvastatina privede do 7-kratnega povečanja plazemske izpostavljenosti simvastatinski kislini.
English: • Pregnancy and breast-feeding (see section 4.6)
Slovenian: • Nosečnost in dojenje (glejte poglavje 4.6)
English: Attention should be paid to patients who develop increase in transaminase levels and therapy should be discontinued if aspartate aminotransferase (AST) or also known as serum glutamic oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT) or also known as serum glutamic pyruvic transaminase (SGPT) levels increase to more than 3 times the upper limit of the normal range.
Slovenian: Zdravljenje je treba prekiniti, če se ravni aspartat-aminotransferaze (AST), ki jo imenujejo tudi serumska glutamat-oksalacetat transaminaza (SGOT), in alanin-aminotransferaze (ALT), ki jo imenujejo tudi serumska glutamat-piruvat transaminaza (SGPT), zvišajo na več kot 3-kratnik zgornje meje normalnega razpona.
English: A few cases of simvastatin overdose have been reported; the maximum dose taken was 3.6 g. All patients recovered without sequelae.
Slovenian: Največji uporabljen odmerek je bil 3,6 g. Vsi bolniki so okrevali brez posledic.
English: It is particularly important to tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Slovenian: Zelo pomembno je, da obvestite zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katero koli zdravilo.
English: Multiple mechanisms may contribute to potential interactions with HMG Co-A reductase inhibitors.
Slovenian: Več mehanizmov lahko prispeva k morebitnemu medsebojnemu delovanju z zaviralci HMG-CoAreduktaze.
English: The repeated administration of simvastatin 40 or 80 mg, the highest dose registered, did not affect the plasma levels of fenofibric acid at steady state.
Slovenian: Večkratno dajanje simvastatina 40 ali 80 mg, kar je največji registrirani odmerek, ni imelo učinka na plazemske ravni fenofibrinske kisline v dinamičnem ravnovesju.
English: What Cholib looks like and contents of the pack
Slovenian: Izgled zdravila Cholib in vsebina pakiranja
English: Intake of 240 mL of grapefruit juice in the morning and simvastatin in the evening also resulted in a 1.9-fold increase in plasma exposure to simvastatin acid.
Slovenian: Vnos 240 ml grenivkinega soka zjutraj in simvastatina zvečer privede do 1,9-kratnega povečanja plazemske izpostavljenosti simvastatinski kislini.
English: The risk of rhabdomyolysis is also increased in patients concomitantly receiving other fibrates or statins.
Slovenian: Tveganje za rabdomiolizo se poveča tudi pri sočasni uporabi drugih fibratov ali statinov.
English: Cholib contains sunset yellow FCF (E110) that may cause allergic reactions.
Slovenian: Zdravilo Cholib vsebuje barvilo sončno rumeno FCF (E110), ki lahko povzroči alergijske reakcije.
English: Maximum plasma concentrations (Cmax) of fenofibrate occur within 2 to 4 hours after oral administration.
Slovenian: Fenofibrat doseže najvišje ravni v plazmi (Cmax) v 2 do 4 urah po peroralnem dajanju.
English: Concomitant administration of amlodipine and simvastatin caused a 1.6-fold increase in exposure of simvastatin acid.
Slovenian: Sočasna uporaba amlodipina in simvastatina privede do 1,6-kratnega povečanja izpostavljenosti simvastatinski kislini.
English: Maternal treatment with simvastatin may reduce the foetal levels of mevalonate which is a precursor of cholesterol biosynthesis.
Slovenian: Zdravljenje matere s simvastatinom lahko zniža plodove ravni mevalonata, ki je prekurzor v biosintezi holesterola.
English: Therefore, caution should be exercised in patients with history of pulmonary embolism.
Slovenian: Zato je potrebna previdnost pri bolnikih s pljučno embolijo v anamnezi.
English: In a three-month oral nonclinical study in the rat species with fenofibric acid, the active metabolite of fenofibrate, toxicity for the skeletal muscles (particularly those rich in type I -slow oxidative- myofibres) and cardiac degeneration, anemia and decreased body weight were seen at exposure levels ≥50- fold the human exposure for the skeletal toxicity and >15 fold for the cardiomyotoxicity.
Slovenian: V trimesečni peroralni neklinični študiji fenofibrinske kisline, aktivnega presnovka fenofibrata, na podganah so opazili toksičnost za skeletne mišice (zlasti tiste z veliko počasnih oksidativnih miofibril tipa I) in degeneracijo srca, anemijo in znižano telesno maso pa so ugotovili pri ≥ 50-kratni človeški izpostavljenosti za skeletno toksičnost in pri >15-kratniku za kardiomiotoksičnost.
English: Cases of interstitial lung disease have been reported with some statins and with fenofibrate, especially with long term therapy (see section 4.8).
Slovenian: Poročali so o primerih intersticijske pljučne bolezni pri sočasni uporabi določenih statinov in fenofibrata, zlasti pri dolgotrajnem zdravljenju (glejte poglavje 4.8).
English: A food-effect study involving administration of this formulation of fenofibrate 145 mg tablets to healthy male and female subjects under fasting conditions and with a high fat meal indicated that exposure (AUC and Cmax) to fenofibric acid is not affected by food.
Slovenian: V študiji učinka hrane na uporabo formulacije tablet s 145 mg fenofibrata pri zdravih moških in ženskah na tešče in po obroku z visoko vsebnostjo maščobe so ugotovili, da hrana ni vplivala na izpostavljenost (AUC in Cmax) fenofibrinski kislini.
English: Potent inhibitors of cytochrome P450 3A4 increase the risk of myopathy and rhabdomyolysis by increasing the concentration of HMG-CoA reductase inhibitory activity in plasma during simvastatin therapy.
Slovenian: Močni zaviralci citokroma P450 3A4 povečajo tveganje za miopatijo in rabdomiolizo zaradi povečanja koncentracije zaviralne aktivnosti HMG-CoA-reduktaze v plazmi med zdravljenjem s simvastatinom.
English: HIV protease inhibitors (e.g. nelfinavir) Nefazodone
Slovenian: Zaviralci proteaze HIV (npr. nelfinavir) Nefazodon
English: Because rifampicin is a potent CYP 3A4 inducer that interferes with simvastatin metabolism, patients undertaking long-term rifampicin therapy (e.g. treatment of tuberculosis) may experience loss of efficacy of simvastatin.
Slovenian: Ker je rifampicin močan induktor CYP 3A4, ki moti presnovo simvastatina, lahko pri bolnikih, ki se dolgotrajno zdravijo z rifampicinom (npr. zdravljenje tuberkuloze), učinkovitost simvastatina upade.
English: The availability of the beta-hydroxyacid to the systemic circulation following an oral dose of simvastatin was found to be less than 5% of the dose.
Slovenian: Uporabnost betahidroksi kisline v sistemskem obtoku po peroralnem odmerku simvastatina je manj kot 5 % odmerka.
English: Therefore, Cholib is not expected to affect plasma concentrations of substances metabolised via CYP 3A4.
Slovenian: Zato za zdravilo Cholib ne pričakujemo učinka na plazemske koncentracije snovi, ki se presnavljajo s CYP 3A4.
English: The combination F145/S40 showed superiority over S40 for LDL-C reduction only at 24 weeks from a non-significant additional 1.2% reduction of LDL-C at 12 weeks to a statistically significant 7.2% reduction at 24 weeks.
Slovenian: Kombinacija F145/S40 se je izkazala za učinkovitejšo v primerjavi z S40 pri znižanju LDL-holesterola le po 24 tednih; z neznačilnega 1,2-odstotnega dodatnega znižanja LDL-holesterola po 12 tednih je po 24 tednih prišlo do statistično značilnega 7,2-odstotnega znižanja.
English: The adverse reactions of Cholib are in line with what is known from its two active substances: fenofibrate and simvastatin.
Slovenian: Neželeni učinki zdravila Cholib so v skladu s tem, kar je znanega o obeh zdravilnih učinkovinah: fenofibratu in simvastatinu.
English: Maximum plasma concentration of active inhibitors is reached approximately 1-2 hours after administration of simvastatin.
Slovenian: Aktivni zaviralci dosežejo najvišje ravni v plazmi v približno 1 do 2 urah po dajanju simvastatina.
English: Some patients have experienced the following serious side effects whilst taking fenofibrate or simvastatin (both active substances in Cholib):
Slovenian: Pri določenih bolnikih so se pojavili naslednji resni neželeni učinki med jemanjem fenofibrata ali simvastatina (oba sta učinkovini v zdravilu Cholib):
English: Drugs or herbal products that inhibit certain enzymes (e.g. CYP3A4) and/or transporter (e.g. OATP1B) pathways may increase simvastatin and simvastatin acid plasma concentrations and may lead to an increased risk of myopathy/rhabdomyolysis.
Slovenian: Zdravila ali pripravki rastlinskega izvora, ki zavirajo določene encime (npr. CYP3A4) in/ali poti prenašalcev (npr. OATP1B), lahko povečajo koncentracije simvastatina in/ali simvastatinske kisline v plazmi ter povečajo tveganje za miopatijo/rabdomiolizo.
English: (medicine for lowering fat levels in the blood)
Slovenian: (zdravilo za zniževanje ravni maščob v krvi),
English: No unchanged fenofibrate can be detected in the plasma.
Slovenian: Nespremenjenega fenofibrat v plazmi ne zaznamo.
English: Your doctor may also want you to have blood tests to check how well your liver is working after you start taking Cholib.
Slovenian: Vaš zdravnik bo morda želel, da opravite krvne preiskave za spremljanje delovanja jeter tudi po začetku jemanja zdravila Cholib.
English: IMNM is clinically characterized by persistent proximal muscle weakness and elevated serum creatine kinase, which persist despite discontinuation of statin treatment.
Slovenian: Klinična znaka IMNM sta dolgotrajna oslabelost proksimalnih mišic in povišana vrednost serumske kreatin kinaze, ki kljub ukinitvi zdravljenja s statini ne izzvenita.
English: • elbasvir or grazoprevir (used to treat hepatitis C virus infection)
Slovenian: • elbasvir ali grazoprevir (zdravili za zdravljenje okužbe z virusom hepatitisa C).
English: • If you are allergic to fenofibrate or simvastatin or any of the other ingredients of Cholib (listed in section 6)
Slovenian: • če ste alergični na fenofibrat ali simvastatin ali katero koli sestavino tega zdravila (navedeno v poglavju 6),
English: Intake of grapefruit juice during treatment with Cholib should therefore be avoided.
Slovenian: Uživanju grenivkinega soka med zdravljenjem z zdravilom Cholib se je zato treba izogniti.
English: Statin 6 weeks run-in
Slovenian: Študija 6-tedensko uvajanje statina
English: Physicians contemplating combined therapy with Cholib and lipid-modifying doses (≥ 1 g/day) of niacin (nicotinic acid) or medicinal products containing niacin should carefully weigh the potential benefits and risks and should carefully monitor patients for any signs and symptoms of muscle pain, tenderness, or weakness, particularly during the initial months of therapy and when the dose of either medicinal product is increased.
Slovenian: Zdravniki, ki načrtujejo kombinirano terapijo z zdravilom Cholib in lipide modificirajočimi odmerki (≥ 1 g/dan) niacina (nikotinske kisline) ali zdravili, ki vsebujejo niacin, morajo skrbno pretehtati možne koristi in tveganja ter natančno spremljati bolnike glede znakov in simptomov mišičnih bolečin, občutljivosti ali šibkosti, zlasti v prvih mesecih zdravljenja in po povečanju odmerka enega ali drugega zdravila.
English: • Unexplained muscle pain, tenderness, or weakness may be sign of muscle break down.
Slovenian: • Nepojasnjene bolečine v mišicah, občutljivost ali šibkost mišic so lahko znaki razpadanja mišic.
English: Cholib has not been studied in patients with hepatic impairment and is therefore contraindicated in this population (see section 4.3).
Slovenian: Zdravilo Cholib ni bilo preučeno pri bolnikih z okvarjenim delovanjem jeter, zato je v tej populaciji kontraindicirano (glejte poglavje 4.3.
English: As simvastatin is contraindicated during pregnancy (see hereafter), Cholib is contraindicated during pregnancy (see section 4.3).
Slovenian: Ker je simvastatin med nosečnostjo kontraindiciran (glejte nadaljevanje), je zdravilo Cholib kontraindicirano med nosečnostjo (glejte poglavje 4.3).
English: Because the dose of simvastatin should not exceed 10 mg daily in patients taking ciclosporin, the co-administration of Cholib with ciclosporin is contraindicated (see section 4.3).
Slovenian: Ker odmerek simvastatina pri bolnikih, ki jemljejo ciklosporin, ne sme preseči 10 mg na dan, je sočasna uporaba zdravila Cholib in ciklosporina kontraindicirana (glejte poglavje 4.3).
English: Inhibitors of Breast Cancer Resistant Protein (BCRP) Concomitant administration of medicinal products that are inhibitors of BCRP, including products containing elbasvir or grazoprevir, may lead to increased plasma concentrations of simvastatin and an increased risk of myopathy (see sections 4.2 and 4.4).
Slovenian: Zaviralci proteina odpornosti pri raku dojke (BCRP) Sočasno dajanje zdravil, ki so zaviralci BCRP, vključno z zdravili, ki vsebujejo elbasvir ali grazoprevir, lahko zviša koncentracijo simvastatina v plazmi in poveča tveganje miopatije (glejte poglavji 4.2 in 4.4).
English: % Change Mean (SD)
Slovenian: Povprečna sprememba v % (SD)
English: This was not significantly different from the 29% (90% CI 22%-35%) reduction in AUC of SVA observed when co-administration was 12 hours apart: simvastatin 40 mg in the evening and fenofibrate 145 mg in the morning.
Slovenian: To ni bilo pomembno drugače od 29-odstotnega zmanjšanja AUC SVK (90-odstotni IZ 22 %-35 %), ki so ga opazili, ko so zdravili dajali z razmakom 12 ur: simvastatin 40 mg zvečer in fenofibrat 145 zjutraj.
English: Studies with fenofibrate on lipoprotein fractions show decreases in levels of LDL and VLDL cholesterol (VLDL-C).
Slovenian: Študije učinkovanja fenofibrata na lipoproteinske frakcije kažejo, da se ravni LDL-holesterola in VLDL-holesterola znižajo.
English: • muscle weakness that is constant
Slovenian: • stalna oslabelost mišic,
English: Treatment emergent adverse reactions reported in patients receiving co-administration of fenofibrate and simvastatin occurring are listed below by system organ class and frequency.
Slovenian: Neželeni učinki, ki so se pojavili med zdravljenjem bolnikov, ki so sočasno prejemali fenofibrat in simvastatin, so v nadaljevanju navedeni po organskih sistemih in pogostnosti.
English: Fenofibric acid is not eliminated by hemodialysis.
Slovenian: Fenofibrinske kisline ni mogoče odstraniti s hemodializo.
English: There have been reports of myopathy and rhabdomyolysis with the concomitant administration of colchicine and simvastatin in patients with renal insufficiency.
Slovenian: Poročali so o miopatiji in rabdomiolizi pri sočasni uporabi kolhicina in simvastatina pri bolnikih z ledvično insuficienco.
English: This occurrence may represent a failure of efficacy in patients with severe hypertriglyceridaemia, an induced pancreatic enzymes increase or a secondary phenomenon mediated through biliary tract stone or sludge formation with obstruction of the common bile duct.
Slovenian: Ta pojav lahko predstavlja neučinkovitost pri bolnikih s hudo hipertrigliceridemijo, inducirano zvišanje encimov trebušne slinavke ali pojav, ki je posledica nastanka žolčnega kamna ali grudice, ki zapre skupni žolčni vod.
English: Amiodarone, amlodipine, diltiazem and verapamil The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, amlodipine, diltiazem or verapamil with simvastatin 40 mg per day.
Slovenian: Amiodaron, amlodipin, diltiazem in verapamil Pri sočasni uporabi amiodarona, amlodipina, diltiazema ali verapamila s simvastatinom v odmerku 40 mg na dan se poveča tveganje za miopatijo in rabdomiolizo.
English: Concomitant administration of products that are inhibitors of BCRP (e.g., elbasvir and grazoprevir) may lead to increased plasma concentrations of simvastatin and an increased risk of myopathy; therefore, a dose adjustment of simvastatin should be considered depending on the prescribed dose.
Slovenian: Sočasno zdravljenje z zdravili, ki so zaviralci BCRP (npr. elbasvir in grazoprevir), lahko zviša koncentracijo simvastatina v plazmi in poveča tveganje miopatije, zato je treba razmisliti o prilagoditvi odmerka simvastatina glede na predpisani odmerek.
English: Simvastatin has been shown to reduce both normal and elevated LDL-C concentrations.
Slovenian: Za simvastatin je dokazano znižanje normalnih in zvišanih ravni LDL-holesterola.
English: Reduced function of hepatic OATP transport proteins can increase the systemic exposure of simvastatin and increase the risk of myopathy and rhabdomyolysis.
Slovenian: Zmanjšano delovanje transportnih proteinov OATP v jetrih lahko zveča sistemsko izpostavljenost simvastatinu in zveča tveganje za miopatijo in rabdomiolizo.
English: Severe cutaneous reactions (e.g erythema multiforme, Ste vens-Johnson syndrome, toxic epidermal necrolysis, etc.)
Slovenian: Bolezni kože in podkožja hude reakcije na koži (npr. multiformni eritem, Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, itd.)
English: Presenting features can include dyspnoea, non-productive cough and deterioration in general health (fatigue, weight loss and fever).
Slovenian: Bolezen se kaže z dispnejo, neproduktivnim kašljem in poslabšanjem splošnega zdravja (utrujenost, izguba telesne mase in zvišana telesna temperatura).
English: During four double blind clinical trials of 24-week duration 1,237 patients have received treatment with co-administered fenofibrate and simvastatin.
Slovenian: V štirih dvojno slepih kliničnih preskušanjih, ki so trajala 24 tednov, je 1.237 bolnikov sočasno prejemalo fenofibrat in simvastatin.
English: Mylan Laboratories SAS Route de Belleville - Lieu-dit Maillard 01400 Châtillon-sur-Chalaronne France
Slovenian: Mylan Laboratories SAS Route de Belleville - Lieu-dit Maillard 01400 Châtillon-sur-Chalaronne Francija
English: Increased blood homocysteine level ***** In the FIELD study the average increase in blood homocysteine level in patients treated with fenofibrate was 6.5 µmol/L, and was reversible on discontinuation of fenofibrate treatment.
Slovenian: Zvišana raven homocisteina v krvi ***** V študiji FIELD se je raven homocisteina v krvi bolnikov, zdravljenih s fenofibratom, v povprečju zvišala za 6,5 µmol/l.
English: Reversible effects on fertility have been observed in animals (see section 5.3).
Slovenian: Pri živalih so ugotovili reverzibilne vplive na plodnost (glejte poglavje 5.3).
English: Whether fenofibrate had an effect on other active metabolites of simvastatin was not investigated.
Slovenian: Morebitnega učinka fenofibrata na druge aktivne presnovke simvastatina niso preučevali.
English: The use of micronised fenofibrate and NanoCrystal® technology for the formulation of the fenofibrate 145 mg tablet enhances its absorption.
Slovenian: Uporaba mikroniziranega fenofibrata in tehnologije NanoCrystal pri izdelavi tablet s 145 mg fenofibrata absorpcijo pospeši.
English: In the other study [Bergman et al, 2004] repeated co-administration of both simvastatin 80 mg and fenofibrate 160 mg led to a reduction in the AUC of the SVA of 36% (90% CI 30%-42%).
Slovenian: V drugi študiji [Bergman in sod., 2004] je večkratno sočasno dajanje simvastatina 80 mg in fenofibrata 160 mg zmanjšalo vrednost AUC SVK za 36 % (90-odstotni IZ 30 %-42 %).
English: Only anecdotal cases of fenofibrate overdose have been received.
Slovenian: Obstajajo samo poročila o nepotrjenih primerih prevelikega odmerjanja fenofibrata.
English: Immune-mediated necrotizing myopathy (IMNM)
Slovenian: Imunsko pogojena nekrotizirajoča miopatija (IMNM)
English: Blood creatinine increased (see sections 4.3 and 4.4)
Slovenian: Preiskave zvišana raven kreatinina v krvi (glejte poglavji 4.3 in 4.4)
English: • you have severe lung disease
Slovenian: • imate hudo bolezen pljuč,
English: Effects of repeated administration of fenofibrate on the pharmacokinetics of single or multiple doses of simvastatin have been investigated in two small studies (n=12) followed by a larger one (n=85) in healthy subjects.
Slovenian: Učinke večkratnega dajanja fenofibrata na farmakokinetiko enkratnega ali večkratnih odmerkov simvastatina so preučevali na zdravih osebah v dveh manjših študijah (n=12), ki jima je sledila večja študija (n=85).
English: Cholib contains types of sugars called lactose and sucrose.
Slovenian: Zdravilo Cholib vsebuje sladkorja, imenovana laktoza in saharoza.
English: The corresponding risk is 0.3% in patients having the most common genotype (TT) (See section
Slovenian: Tveganje pri bolnikih z najpogostejšim genotipom (TT) je 0,3 % (glejte poglavje 5.2).
English: As this medicinal product contains sucrose, patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Slovenian: Ker to zdravilo vsebuje saharozo, bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkljivostjo saharaze-izomaltaze, tega zdravila ne smejo jemati.
English: Mean Percent Change from Baseline to 12 Weeks Full Analysis Subject Sample
Slovenian: Povprečna odstotna sprememba po 12 tednih od izhodišča Celotna analiza vzorca preiskovancev
English: If it is suspected a patient has developed interstitial lung disease, Cholib therapy should be discontinued.
Slovenian: Če pri bolniku sumite na intersticijsko pljučno bolezen, je treba zdravljenje z zdravilom Cholib prekiniti.
English: Additional information on the individual active substances of the fixed dose combination Additional adverse reactions associated with the use of medicinal products containing simvastatin or fenofibrate observed in clinical trials and postmarketing experience that may potentially occur with Cholib are listed below.
Slovenian: Dodatne informacije o posameznih učinkovinah v fiksni kombinaciji odmerkov V nadaljevanju so navedeni dodatni neželeni učinki, ki so povezani z uporabo zdravil, ki vsebujejo simvastatin ali fenofibrat, in so bili ugotovljeni v kliničnih preskušanjih ali v obdobju trženja zdravila, ki se lahko pojavijo pri uporabi zdravila Cholib.
English: Paediatric population Cholib is contraindicated in children and adolescents up to 18 years old.
Slovenian: Pediatrična populacija Zdravilo Cholib je kontraindicirano pri otrocih in mladostnikih do 18 let (glejte poglavje 4.3).
English: • complications of gall stones such as colic because of stones in bile duct, infection of the bile ducts or gall bladder
Slovenian: • zapleti zaradi žolčnih kamnov, kot je kolika zaradi kamnov v žolčevodu, okužba žolčevoda ali žolčnika,
English: Therefore, the co-administration of Cholib with gemfibrozil, other fibrates, or statins is contraindicated (see section 4.3).
Slovenian: Zato je sočasna uporaba zdravila Cholib in gemfibrozila, drugih fibratov ali statinov kontraindicirana (glejte poglavje 4.3).
English: Therefore it is recommended to monitor HDL-C if Cholib is co-administered with a glitazone and stopping either therapy if HDL-C is too low.
Slovenian: Zato je priporočljivo spremljati HDL-holesterol, če se zdravilo Cholib uporablja sočasno z glitazonom, in ukiniti eno od zdravil, če je raven HDL-holesterola prenizka.
English: • anticoagulants such as warfarin, fluindione, phenprocoumone or acenocoumarol
Slovenian: • antikoagulanti, kot so varfarin, fluindion, fenprokumon ali acenokumarol (zdravila za preprečevanje strjevanja krvi),
English: No effects on fertility were detected in non-clinical reproductive toxicity studies conducted with fenofibrate.
Slovenian: Učinka na plodnost niso zaznali tudi v nekliničnih študijah učinkov fenofibrata na razmnoževanje.
English: Simva 40 (N=505) Mean (SD)
Slovenian: Simva 40 (N=505) Povprečje (SD)