FrancophonIA/ELRC3.0 huggingface dataset:
English: Renal impairment is not expected to modify the pharmacokinetics of dronedarone because no unchanged compound was excreted in urine and only approximately 6% of the dose was excreted in urine as metabolites (see section 4.2).
Croatian: Ne očekuje se da će oštećenje bubrežne funkcije izmijeniti farmakokinetiku dronedarona jer se mokraćom ne izlučuje spoj u neizmijenjenu obliku, a svega 6% doze izlučuje se mokraćom u obliku metabolita
English: Dronedarone is contraindicated in patients with severe hepatic impairment because of the absence of data (see sections 4.3 and 4.4).
Croatian: Zbog nedostatka podataka dronedaron je kontraindiciran u bolesnika s teškim oštećenjem funkcije jetre (vidjeti dio 4.3 i 4.4).
English: Moreover, beta-blockers have the potential to interact with dronedarone from a pharmacodynamic point of view.
Croatian: Osim toga, beta-blokatori mogu stupiti i u farmakodinamičku interakciju s dronedaronom.
English: No dose adjustment is required in other patients with renal impairment (see sections 4.4 and 5.2).
Croatian: U ostalih bolesnika s oštećenjem bubrežne funkcije nije potrebno prilagođavati dozu (vidjeti dio 4.4 i 5.2).
English: You must not take any of the following with MULTAQ:
Croatian: Sljedeće lijekove ne smijete uzimati s lijekom MULTAQ:
English: Statins
Croatian: Statini
English: MULTAQ must not be given to patients with left ventricular systolic dysfunction or to patients with current or previous episodes of heart failure.
Croatian: MULTAQ se ne smije davati bolesnicima sa sistoličkom disfunkcijom lijeve klijetke ni bolesnicima koji boluju ili su bolovali od zatajenja srca.
English: • feeling tired,
Croatian: • umor,
English: • Liver problems including life threatening liver failure.
Croatian: • Tegobe s jetrom uključujući po život opasno zatajenje jetre.
English: Dronedarone 400 mg twice daily does not increase the steady state theophylline exposure.
Croatian: Dronedaron u dozi od 400 mg dvaput na dan ne povećava izloženost teofilinu u stanju dinamičke ravnoteže.
English: It prolongs Wenckebach cycle length and AH-, PQ-, QT- intervals; with no marked effect or weak increase on QTc-intervals, and with no change in HV- and QRS- intervals.
Croatian: Nema primjetan utjecaj na QTc-interval ili ga samo neznatno produljuje, a ne utječe ni na HV- ni QRS-interval.
English: The major metabolic pathway includes N-debutylation to form the main circulating active metabolite followed by oxidation, oxidative deamination to form the inactive propanoic acid metabolite, followed by oxidation, and direct oxidation.
Croatian: Nakon toga slijedi oksidacija i oksidativna deaminacija kojom nastaje neaktivni metabolit propionska kiselina, a zatim nastupaju oksidacija i izravna oksidacija.
English: • skin problems such as rash or itching,
Croatian: • kožne tegobe poput osipa ili svrbeža,
English: Dronedarone is extensively metabolised, mainly by CYP 3A4 (see section 4.5).
Croatian: Biotransformacija Dronedaron se u velikoj mjeri metabolizira, prvenstveno posredstvom CYP3A4 (vidjeti dio 4.5).
English: • Permanent AF with an AF duration ≥6 months (or duration unknown) and attempts to restore sinus rhythm no longer considered by the physician
Croatian: • primjena u permanentnoj fibrilaciji atrija definiranoj kao trajanje fibrilacije atrija ≥6 mjeseci (ili je trajanje nepoznato) i kada liječnik više ne pokušava vratiti sinusni ritam
English: If left ventricular systolic dysfunction develops, treatment with dronedarone should be discontinued.
Croatian: Razvije li se sistolička disfunkcija lijeve klijetke, liječenje dronedaronom mora se prekinuti.
English: Other antiarrhythmic medicinal products had to be withdrawn for at least 5 plasma half-lives prior to the first administration.
Croatian: Bolji placebo primjenu drugih antiaritmika trebalo je prekinuti tijekom razdoblja koje odgovara razdoblju od najmanje 5 poluvjekova lijeka u plazmi.
English: Dronedarone had no genotoxic effects, based on one in vivo micronucleus test in mice and four in vitro tests.
Croatian: Prema rezultatima jednog mikronukleusnog testa na miševima in vivo i četiri istraživanja in vitro,
English: However, spontaneously reported cases of rhabdomyolysis when dronedarone was given in combination with a statin (simvastatin in particular) have been reported, and, therefore, concomitant use of statins should be undertaken with caution.
Croatian: Međutim, zabilježeni su spontano prijavljeni slučajevi rabdomiolize kada se dronedaron davao u kombinaciji sa statinima
English: Liver function
Croatian: Oštećenje funkcije jetre
English: Abdominal pain Dyspepsia
Croatian: bol u abdomenu, dispepsija
English: This will give you more details on exactly what medicines you cannot take with MULTAQ), - if you have a severe liver problem, - if you have a severe kidney problem, - if you take dabigatran (see section below on “Other medicines and MULTAQ”).
Croatian: - ako imate teške probleme s jetrom, - ako imate teške probleme s bubrezima, - ako uzimate dabigatran (pogledajte dio "Drugi lijekovi i MULTAQ" u nastavku).
English: Potent CYP3A4 inducers such as rifampicin, phenobarbital, carbamazepine, phenytoin or St John's Wort are not recommended.
Croatian: Ne preporučuje se primjena potentnih induktora CYP3A4 poput rifampicina, fenobarbitala, karbamazepina, fenitoina ili Gospine trave.
English: Medicinal products inducing torsades de pointes such as phenothiazines, cisapride, bepridil, tricyclic antidepressants, certain oral macrolides (such as erythromycin), terfenadine and Class I and III antiarrhythmics are contraindicated because of the potential risk of proarrhythmia (see section 4.3).
Croatian: • Lijekovi koji induciraju torsades de pointes, poput fenotiazina, cisaprida, bepridila, tricikličkih antidepresiva, terfenadina i nekih peroralnih makrolida (poput eritromicina), antiaritmika skupine I i III (vidjeti dio 4.5)
English: MULTAQ 400 mg film-coated tablets dronedarone
Croatian: MULTAQ 400 mg filmom obložene tablete dronedaron
English: Rare (1/10,000 to disorders test abnormalities liver injury, including life-threatening acute liver failure (see section 4.4)
Croatian: Poremećaji jetre i žuči poremećene vrijednosti testova jetrene funkcije hepatocelularno oštećenje jetre, uključujući po život opasno akutno zatajenje jetre (vidjeti dio 4.4)
English: • Severe renal impairment (CrCl <30 ml/min)
Croatian: • Teško oštećenje funkcije bubrega (klirens kreatinina < 30 ml/min) • Istodobna primjena s dabigatranom
English: This rate should be considered in the context of the underlying elevated incidence of CHF in AF patients.
Croatian: Tu stopu treba razmatrati u kontekstu već postojeće povećane incidencije kongestivnog zatajenja srca u bolesnika s fibrilacijom atrija.
English: Potent CYP3A4 inducers
Croatian: Potentni induktori CYP3A4
English: In patients ≥75years old, clinical signs of heart failure and ECG should be monitored on a regular basis when co-morbidities are present (see sections 4.3, 4.4 and 5.1).
Croatian: Potrebno je redovito pratiti kliničke znakove zatajenja srca i EKG u starijih bolesnika u dobi od ≥75 godina (vidjeti dio 4.2 i 5.1).
English: Dronedarone is a moderate inhibitor of CYP 3A4, a mild inhibitor of CYP 2D6 and a potent inhibitor of P-glycoproteins (P-gp).
Croatian: Dronedaron je umjereno snažan inhibitor CYP3A4, slab inhibitor CYP2D6 i snažan inhibitor
English: Blood creatinine increased* QTc Bazett prolonged # * ≥10% five days after treatment initiation (see section 4.4) # >450 msec in male >470 msec in female (see section 4.4) Description of selected adverse reactions
Croatian: # > 450 msek u muškaraca; > 470 msek u žena (vidjeti dio 4.4) Opis odabranih nuspojava
English: Moreover, due to their heart rate-lowering properties, verapamil and diltiazem have the potential to interact with dronedarone from a pharmacodynamic point of view.
Croatian: Osim toga, budući da utječu na usporavanje srčanog ritma, verapamil i diltiazem mogu s farmakodinamičkog stajališta ući u interakciju s dronedaronom.
English: Each film-coated tablet contains 400 mg of dronedarone (as hydrochloride).
Croatian: Jedna filmom obložena tableta sadrži 400 mg dronedarona (u obliku dronedaronklorida).
English: If patients treated with dronedarone develop permanent AF, treatment with dronedarone should be discontinued.
Croatian: Ako se u bolesnika liječenih dronedaronom razvije permanentna fibrilacija atrija, liječenje dronedaronom mora se prekinuti.
English: Common (1/100 to
Croatian: (≥1/1000 i <1/100)
English: • Opaque PVC/Aluminium blister in packs of 20, 50 and 60 film-coated tablets • Opaque PVC/Aluminium perforated unit dose blister in packs of 100x1 film-coated tablets.
Croatian: • Neprozirni PVC/aluminij perforirani blister s jediničnim dozama sa 100x1 filmom obloženom tabletom
English: It should be taken as:
Croatian: Lijek treba uzimati na sljedeći način:
English: • changes in your ECG (electrocardiogram) called QTc Bazett prolonged.
Croatian: • promjene u nalazima jedne krvne pretrage: razina kreatinina u krvi, • promjene na EKG-u (elektrokardiogramu) koje se zovu produljenje QTc-intervala prema Bazettu.
English: Interaction with medicinal products metabolized by CYP 3A4 Dabigatran
Croatian: Interakcija s lijekovima koji se metaboliziraju pomoću CYP3A4
English: Calcium antagonists also have their exposure increased by dronedarone (400 mg twice daily) (verapamil by 1.4-fold, and nisoldipine by 1.5-fold).
Croatian: Dronedaron (400 mg dvaput na dan) također povećava izloženost antagonistima kalcija (1,4 puta veća izloženost verapamilu i 1,5 puta veća izloženost nisoldipinu).
English: Dronedarone was not shown to alter fertility in animal studies.
Croatian: Ispitivanja na životinjama nisu pokazala da dronedaron utječe na plodnost.
English: It also inhibits the sodium currents (Class Ib) and the calcium currents (Class IV).
Croatian: Također inhibira protok natrija (skupina Ib)
English: • bepridil for chest pain caused by heart disease,
Croatian: • neke lijekove za smirenje koji se zovu fenotiazini, • bepridil, za bolove u prsištu uzrokovane bolešću srca,
English: Repeated doses of diltiazem (240 mg twice daily), verapamil (240 mg once daily) and nifedipine (20 mg twice daily) resulted in an increase in dronedarone exposure of 1.7-, 1.4- and 1.2-fold, respectively.
Croatian: Ponovljene doze diltiazema (240 mg dvaput na dan), verapamila (240 mg jednom na dan) i nifedipina
English: The co-administration of beta-blockers or calcium antagonists with depressant effect on sinus and atrio-ventricular node should be undertaken with caution.
Croatian: Beta-blokatori i antagonisti kalcija Potreban je oprez prilikom istodobne primjene beta-blokatora ili antagonista kalcija s depresorskim učincima na sinusni i atrioventrikularni čvor.
English: If a switch is envisaged, this should be done under the supervision of a specialist (see sections 4.3 and 5.1).
Croatian: Ako se predviđa prelazak bolesnika na dronedaron, to se mora provesti pod nadzorom specijaliste (vidjeti dio 4.3 i
English: When dabigatran etexilate 150 mg once daily was co-administered with dronedarone 400 mg twice daily, the dabigatran AUC0-24, and Cmax were increased by 100% and 70%, respectively.
Croatian: 400 mg dvaput na dan, AUC0-24 dabigatrana povećao se za 100%, a njegov Cmax za 70%.
English: There have been spontaneously reported events of new or worsening heart failure during treatment with dronedarone.
Croatian: Tijekom liječenja dronedaronom spontano su prijavljeni slučajevi novonastalog ili pogoršanja postojećeg zatajenja srca.
English: Prevention of drug-drug interaction
Croatian: - interakcije lijekova
English: In patients aged 65 years of age and over, dronedarone exposures are 23% higher in comparison with patients aged below 65 years of age.
Croatian: U bolesnika u dobi od 65 ili više godina izloženost dronedaronu bila je 23%
English: No clinical data are available regarding the co-administration of these medicinal products in AF patients.
Croatian: Nema kliničkih podataka o istodobnoj primjeni navedenih lijekova u bolesnika s fibrilacijom atrija.
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children.
Croatian: Kako čuvati MULTAQ Lijek čuvajte izvan pogleda i dohvata djece.
English: MULTAQ 400 mg
Croatian: 16. PODACI NA BRAILLEOVOM PISMU MULTAQ 400 mg
English: During the course of the study, the number of deaths from any cause was comparable between the dronedarone (116/2,301) and placebo (139/2,327) groups.
Croatian: (116/2301) i onoj koja je primala placebo (139/2327).
English: Dronedarone (400 mg twice daily) increased simvastatin and simvastatin acid exposure by 4-fold and 2-fold respectively.
Croatian: Primjena dronedarona (400 mg dvaput na dan) četverostruko je povećala izloženost simvastatinu, a dvostruko izloženost simvastatinskoj kiselini.
English: If ALT levels are confirmed to be ≥3 × ULN, treatment with dronedarone should be withdrawn.
Croatian: Ako se potvrdi da su razine ALT-a ≥ 3 x GGN, mora se prekinuti liječenje dronedaronom.
English: Monitoring of their plasma concentrations and appropriate dose adjustment is recommended in case of coadministration with dronedarone.
Croatian: U slučaju istodobne primjene s dronedaronom preporučuje se praćenje njihovih koncentracija u plazmi i odgovarajuća prilagodba doze.
English: NAME OF THE MEDICINAL PRODUCT MULTAQ 400 mg tablets dronedarone
Croatian: NAZIV LIJEKA MULTAQ 400 mg tablete dronedaron
English: The PALLAS study was a randomised placebo-controlled study investigating the clinical benefit of dronedarone 400 mg BID on top of standard therapy in patients with permanent atrial fibrillation and additional risk factors (patients with congestive heart failure ~ 69%, coronary heart disease ~ 41%, prior stroke or TIA ~ 27%; LVEF ≤40% ~ 20.7% and patients ≥75 years with hypertension and diabetes ~ 18%).
Croatian: koronarnom bolešću srca u ~ 41%, pretrpljenim moždanim udarom ili tranzitornom ishemijskom atakom u ~ 27%, ejekcijskom frakcijom lijeve klijetke ≤ 40% u ~ 20,7% te dobi od ≥ 75 godina uz hipertenziju i dijabetes u ~ 18% bolesnika).
English: • change in how things taste.
Croatian: • promjene osjeta okusa, Rijetke
English: Cases of interstitial lung disease including pneumonitis and pulmonary fibrosis have been reported in post-marketing experience (frequency not known).
Croatian: Nakon stavljanja lijeka u promet prijavljeni su slučajevi intersticijske bolesti pluća, uključujući pneumonitis i plućnu fibrozu (učestalost nepoznata).
English: In patients already taking beta-blockers at time of dronedarone initiation, an ECG should be performed and the dose of beta-blocker should be adjusted if needed (see section 4.4).
Croatian: U bolesnika koji već uzimaju beta-blokatore u vrijeme započinjanja liječenja dronedaronom, potrebno je napraviti EKG i ako je potrebno prilagoditi dozu beta-blokatora (vidjeti dio 4.4).
English: In elderly patients ≥75 years with multiple co-morbidities, clinical signs of heart failure and ECG should be monitored on a regular basis (see sections 4.2 and 5.1).
Croatian: U bolesnika u dobi od ≥ 75 godina s popratnim bolestima (vidjeti dio 4.3, 4.4 i 5.1), nužno je redovito pratiti kliničke znakove zatajenja srca i EKG.
English: The educational material is a Prescriber Guide to:
Croatian: Edukacijski materijal je Vodič za liječnike propisivače za: • probir bolesnika prije početka liječenja
English: Based on clinical experience, dronedarone has a low pro-arrhythmic effect and has shown a decrease in arrhythmic death in the ATHENA study (see section 5.1).
Croatian: Kliničko iskustvo pokazalo je da dronedaron ima slab proaritmijski učinak, a u ispitivanju ATHENA
English: Moderate/weak CYP 3A4 inhibitors
Croatian: Umjereni/slabi inhibitori CYP3A4
English: Renal impairment
Croatian: Bolji dronedaron
English: Other moderate/weak CYP 3A4 Inhibitors
Croatian: Ostali umjereni/slabi inhibitori CYP3A4
English: MAO inhibitors
Croatian: Inhibitori monoaminooksidaze
English: Adverse reactions are presented by system organ class.
Croatian: Nuspojave su prikazane prema klasifikaciji organskih sustava.
English: Potent CYP 3A4 inhibitors
Croatian: Potentni inhibitori CYP3A4
English: Beta-blockers that are metabolised by CYP 2D6 can have their exposure increased by dronedarone.
Croatian: Dronedaron može povećati izloženost beta-blokatorima koji se metaboliziraju pomoću CYP2D6.
English: Interactions (see section 4.5)
Croatian: Interakcije (vidjeti dio 4.5) Digoksin
English: Patients with history of, or current heart failure or left ventricular systolic dysfunction
Croatian: Bolesnici s u anamnezi zabilježenim ili trenutnim zatajenjem srca ili sistoličkom disfunkcijom lijeve klijetke
English: If you have had a pacemaker fitted for this problem, you can use MULTAQ, - if you have a very slow heart beat (less than 50 beats a minute), - if your ECG (electrocardiogram) shows a heart problem called “prolonged QT corrected interval” (this interval is more than 500 milliseconds), - if you have a type of atrial fibrillation called permanent atrial fibrillation (AF).
Croatian: QT-interval" (interval traje dulje od 500 milisekundi), - ako imate jednu vrstu fibrilacije atrija koja se naziva permanentnom fibrilacijom atrija.
English: • other medicines used to control an irregular or fast heart beat such as flecainide, propafenone,
Croatian: • druge lijekove koji se koriste za regulaciju nepravilnih ili ubrzanih otkucaja srca, kao što su flekainid, propafenon, kinidin, disopiramid, dofetilid, sotalol, amiodaron,
English: Patients developing permanent AF during treatment
Croatian: Bolesnici u kojih se tijekom liječenja razvije permanentna fibrilacija atrija
English: Digoxin
Croatian: Digitalis
English: NAME OF THE MEDICINAL PRODUCT MULTAQ 400 mg film-coated tablets
Croatian: NAZIV LIJEKA MULTAQ 400 mg filmom obložene tablete
English: Screen patients before treatment initiation Contra indication of Permanent Atrial fibrillation Contra indication of history, or current heart failure or left ventricular systolic dysfunction (LVSD)
Croatian: - kontraindikacija - permanentna fibrilacija atrija - kontraindikacija - trenutačno ili u anamnezi zabilježeno zatajenje srca ili sistolička disfunkcija lijeve klijetke - prevencija interakcija lijekova
English: - if you are allergic to dronedarone or to any of the other ingredients of this medicine (listed in section 6), - if you have a problem with the nerves in your heart (heart block).
Croatian: Nemojte uzimati MULTAQ - ako ste alergični na dronedaron ili neki drugi sastojak ovog lijeka (naveden u dijelu 6),
English: The study was stopped prematurely due to an observed imbalance of deaths in the dronedarone group [n = 25 versus 12 (placebo), p = 0.027] (see sections 4.3 and 4.4).
Croatian: (placebo), p = 0,027] (vidjeti dio 4.3 i 4.4).
English: Moreover, digitalis has the potential to interact with dronedarone from a pharmacodynamic point of view.
Croatian: Nadalje, s farmakodinamičkog stajališta, digitalis može ući u interakciju s dronedaronom.
English: Nervous system disorders
Croatian: Poremećaji živčanog sustava disgeuzija ageuzija
English: • MULTAQ is not recommended if you are pregnant or you think you may be pregnant.
Croatian: • Ako ste trudni ili mislite da biste mogli biti trudni, ne preporučuje se primjena lijeka MULTAQ.
English: After oral administration in fed conditions, peak plasma concentrations of dronedarone and the main circulating active metabolite (N-debutyl metabolite) are reached within 3 to 6 hours.
Croatian: Nakon peroralne primjene uz obrok vršne koncentracije dronedarona i glavnog aktivnog cirkulirajućeg metabolita
English: Pharmacodynamic properties
Croatian: Farmakodinamički učinci
English: 5 How to store MULTAQ Contents of the pack and other information
Croatian: Kako MULTAQ izgleda i sadržaj pakiranja
English: A clinical study in patients with permanent AF (AF duration for at least 6 months) and cardiovascular risk factors was stopped early due to an excess of cardiovascular death, stroke and heart failure in patients receiving dronedarone (see section 5.1).
Croatian: i faktorima kardiovaskularnog rizika prijevremeno je prekinuto zbog prevelikog broja slučajeva smrti zbog kardiovaskularnih uzroka, moždanog udara i zatajenja srca u bolesnika koji su primali dronedaron
English: Liver, pulmonary, coagulation and renal function tests Counsel patients about its use
Croatian: - testovi funkcije jetre, pluća, koagulacije i bubrega
English: In patients already on calcium antagonists at time of dronedarone initiation, an ECG should be performed and the calcium antagonist dose should be adjusted if needed (see section 4.4).
Croatian: U bolesnika koji u vrijeme započinjanja liječenja dronedaronom već uzimaju antagoniste kalcija ili beta-blokatore treba snimiti EKG i po potrebi prilagoditi dozu antagonista kalcija (vidjeti dio 4.4).
English: Dronedarone is contraindicated in patients in unstable hemodynamic conditions, with history of, or current heart failure or left ventricular systolic dysfunction (see section 4.3).
Croatian: Dronedaron je kontraindiciran u bolesnika u nestabilnom hemodinamičkom stanju koji pate od zatajenja srca ili sistoličke disfunkcije lijeve klijetke ili imaju zatajenje srca ili sistoličku disfunkciju lijeve klijetke u anamnezi.
English: Titanium dioxide (E171) Carnauba wax (E903)
Croatian: hipromeloza (E464), makrogol 6000, titanijev dioksid (E171), karnauba vosak (E903).
English: 100x1 film-coated tablets
Croatian: 20 filmom obloženih tableta 50 filmom obloženih tableta 60 filmom obloženih tableta 100x1 filmom obložena tableta
English: An increase in plasma creatinine (mean increase 10 μmol/L) has been observed with dronedarone 400 mg twice daily in healthy subjects and in patients.
Croatian: Kod primjene dronedarona u dozi od 400 mg dvaput na dan u zdravih ispitanika i u bolesnika primijećeno je povišenje razine kreatinina u plazmi (srednje povišenje 10 µmol/l).
English: If AF reoccurs, discontinuation of dronedarone should be considered.
Croatian: Ako se ponovno javi fibrilacija atrija, treba razmotriti prekid liječenja dronedaronom.
English: • Severe hepatic impairment
Croatian: • intersticijska bolest pluća
English: In permanent AF, the AF has been present for a long time (at least during 6 months) and a decision has been made not to change back your heart rhythm to atrial normal rhythm with a treatment called cardioversion, - if you have instability (drops) in your blood pressure which can lead to inadequate arterial blood flow to your organs,
Croatian: U slučaju permanentne fibrilacije atrija, fibrilacija je prisutna dulje vrijeme (najmanje 6 mjeseci) te je donesena odluka da se srčani ritam ne vraća u normalan atrijski ritam postupkom koji se zove kardioverzija,
English: • you have swollen feet or legs, trouble breathing when lying down or sleeping, shortness of breath when moving around, or weight increase (which are signs and symptoms of heart failure),
Croatian: Možete imati otečena stopala ili noge, tegobe s disanjem u ležećem položaju ili dok spavate ili možete osjetiti nedostatak zraka kad ste u pokretu,
English: Some cases also reported increases in blood urea nitrogen possibly due to hypoperfusion secondary to developing CHF (pre-renal azotaemia).
Croatian: vjerojatno zbog hipoperfuzije kao posljedice razvoja kongestivnog zatajenja srca (prerenalna azotemija).
English: Heart Failure (including use in patients with unstable hemodynamic conditions with history of, or current heart failure or left ventricular systolic dysfunction, and pre-renal azotemia) Use in Permanent atrial fibrillation defined as an AF duration ≥6 months (or duration unknown) and attempts to restore sinus rhythm no longer considered by the physician Pulmonary-interstitial lung disease (ILD)
Croatian: • zatajenje srca (uključujući primjenu u bolesnika s nestabilnim hemodinamičkim stanjima, sa trenutnim ili u anamnezi zabilježenim zatajenjem srca ili sistoličkom disfunkcijom lijeve klijetke i prerenalnom azotemijom)