FrancophonIA/ELRC3.0 huggingface dataset:
English: Savio S.R.L.
Latvian: I.B.N. Savio S.R.L.
English: Metformin Tillomed Laboratories
Latvian: Tillomed Laboratories Ltd Metformin Tillomed Laboratories
English: Metformin 850mg Tablet
Latvian: Formet metformīns, 850 mg tablete
English: France Ranbaxy Pharmacie Generiques Metformine Ranbaxy
Latvian: Bluefish Pharmaceuticals Ab Metformine Ranbaxy
English: Metformine Hcl Usv Europe Metformin Hydrochloride 500mg Tablet
Latvian: Metformine Hcl Usv Europe metformīna hidrohlorīds, 500 mg tablete
English: Germany Heumann Pharma Gmbh & Co. Generica Kg
Latvian: Heumann Pharma Gmbh & Co.
English: Aurobindo Pharma (Malta) Limited Metformin Hydrochloride Aurobindo Pharma (Malta)
Latvian: Aurobindo Pharma Limited Metformin Hydrochloride Aurobindo Pharma
English: Metformin 500mg Tablet
Latvian: Formet metformīns, 500 mg tablete
English: Morningside Healthcare Ltd
Latvian: Morningside Healthcare Ltd Metabet Sr
English: Metformin Hcl Plus Pharmacie Metformin Hydrochloride 500mg Tablet
Latvian: Metformin Hcl Plus Pharmacie metformīna hidrohlorīds, 500 mg tablete
English: Metformine Hcl Usv Europe Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Latvian: Metformine Hcl Usv Europe metformīna hidrohlorīds, 1 000 mg tablete
English: Aurobindo Pharma Limited
Latvian: Aurobindo Pharma (Malta) Limited
English: Pinewood Laboratories Limited Metformin Hydrochloride Pinewood Laboratories
Latvian: Pinewood Laboratories Limited
English: Austria 1a Pharma Gmbh
Latvian: 1a Pharma Gmbh
English: Metformin 1000mg Tablet
Latvian: Formet metformīns, 1 000 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Empagliflozin 12.5mg Tablet
Latvian: Synjardy metformīna hidrohlorīds, 1 000 mg tablete, empagliflozīns, 12,5 mg tablete
English: Metformin Hydrochloride 850mg Tablet, Linagliptin 2.5mg Tablet
Latvian: Jentadueto metformīna hidrohlorīds, 850 mg tablete, linagliptīns, 2,5 mg tablete
English: Metformina Mylan Generics Metformin Hydrochloride 500mg Tablet
Latvian: Metformina Mylan Generics metformīna hidrohlorīds, 500 mg tablete
English: Metformin Hydrochloride 500mg G
Latvian: Metformax metformīna hidrohlorīds, 500 mg G
English: Metformin Hydrochloride 850mg Tablet, Alogliptin 25mg Tablet
Latvian: Vipdomet metformīna hidrohlorīds, 850 mg tablete, alogliptīns, 25 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Linagliptin 2.5mg Tablet
Latvian: Jentadueto metformīna hidrohlorīds, 1 000 mg tablete, linagliptīns, 2,5 mg tablete
English: Metformin Hcl Plus Pharmacie Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Latvian: Metformin Hcl Plus Pharmacie metformīna hidrohlorīds, 1 000 mg tablete
English: Metformin/Glibenklamid Lek Metformin Hydrochloride 500mg Tablet, Glibenclamide 2.5mg Tablet
Latvian: Metformin/Glibenklamid Lek metformīna hidrohlorīds, 500 mg tablete, glibenklamīds, 2,5 mg tablete
English: Metformina Mylan Generics Metformin Hydrochloride 850mg Tablet
Latvian: Metformina Mylan Generics metformīna hidrohlorīds, 850 mg tablete
English: Metwest Pharmaceuticals Limited Metformin Metwest Pharmaceuticals
Latvian: Metwest Pharmaceuticals Limited
English: Metformin Hydrochloride 850mg Tablet, Alogliptin 12.5mg Tablet
Latvian: Vipdomet metformīna hidrohlorīds, 850 mg tablete, alogliptīns, 12,5 mg tablete
English: Germany Denk Pharma Gmbh & Co. Kg Metfo
Latvian: Denk Pharma Gmbh & Co.
English: Metformin Hydrochloride 850mg Tablet, Empagliflozin 12.5mg Tablet
Latvian: Synjardy metformīna hidrohlorīds, 850 mg tablete, empagliflozīns, 12,5 mg tablete
English: Metformin Hydrochloride 100mg/Ml
Latvian: Metformin/Alapis metformīna hidrohlorīds, 100 mg/ Ml
English: Germany Juta Pharma Gmbh
Latvian: Juta Pharma Gmbh
English: Metformin Hydrochloride 1000mg
Latvian: Risidon metformīna hidrohlorīds, 1 000 mg paciņa
English: Germany Tad Pharma Gmbh
Latvian: Tad Pharma Gmbh
English: Metformin Crescent Pharma Metformin Hydrochloride 500mg Tablet
Latvian: Crescent Pharma Limited Metformin Crescent Pharma metformīna hidrohlorīds, 500 mg tablete
English: Metformin Hydrochloride 850mg Tablet, Pioglitazone 15mg Tablet
Latvian: Glubrava metformīna hidrohlorīds, 850 mg tablete, pioglitazons, 15 mg tablete
English: Metformin/Glibenklamid Lek Metformin Hydrochloride 500mg Tablet, Glibenclamide 5mg Tablet
Latvian: Metformin/Glibenklamid Lek metformīna hidrohlorīds, 500 mg tablete, glibenklamīds, 5 mg tablete
English: Metformin Relonchem Metformin Hydrochloride 850mg Tablet
Latvian: Metformin Relonchem metformīna hidrohlorīds, 850 mg tablete
English: Metformine Arrow Generiques Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Latvian: Metformine Arrow Generiques metformīna hidrohlorīds, 1 000 mg tablete
English: Metformin Relonchem Metformin Hydrochloride 500mg Tablet
Latvian: Metformin Relonchem metformīna hidrohlorīds, 500 mg tablete
English: Metformin Hydrochloride 850mgg
Latvian: metformīna hidrohlorīds, 850 mg paciņa
English: Metformin Crescent Pharma Metformin Hydrochloride 850mg Tablet
Latvian: Crescent Pharma Limited Metformin Crescent Pharma metformīna hidrohlorīds, 850 mg tablete
English: Metformin Hydrochloride 500ml/5 Ml
Latvian: Metformin Hydrochloride Rosemont metformīna hidrohlorīds, 500 ml/5 Ml
English: Metformin Hydrochloride 1000mg Tablet, Sitagliptin 50mg Tablet
Latvian: Ristfor metformīna hidrohlorīds, 1 000 mg tablete, sitagliptīns, 50 mg tablete
English: Metformin Hydrochloride 850mg
Latvian: Risidon metformīna hidrohlorīds, 850 mg paciņa
English: Metformin Hydrochloride 1000mg Tablet, Empagliflozin 5mg Tablet
Latvian: Synjardy metformīna hidrohlorīds, 1 000 mg tablete, empagliflozīns, 5 mg tablete
English: Metformin Hydrochloride 400mg Tablet, Glibenclamide 2.5mg Tablet
Latvian: metformīna hidrohlorīds, 400 mg tablete, glibenklamīds, 2,5 mg tablete
English: Metformin Hcl Ratiopharm Metformin Hydrochloride 850mg Tablet
Latvian: Metformin Hcl Ratiopharm metformīna hidrohlorīds, 850 mg tablete
English: Metformin Hydrochloride 850mg Tablet, Sitagliptin 50mg Tablet
Latvian: Ristfor metformīna hidrohlorīds, 850 mg tablete, sitagliptīns, 50 mg tablete
English: Metformin Hydrochloride 850mg Tablet, Empagliflozin 5mg Tablet
Latvian: Synjardy metformīna hidrohlorīds, 850 mg tablete, empagliflozīns, 5 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Canagliflozin 50mg Tablet
Latvian: Vokanamet metformīna hidrohlorīds, 1 000 mg tablete, kanagliflozīns, 50 mg tablete
English: Metformin Hcl Ratiopharm Metformin Hydrochloride 500mg Tablet
Latvian: Metformin Hcl Ratiopharm metformīna hidrohlorīds, 500 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Glibenclamide 5mg Tablet
Latvian: Glucovance metformīna hidrohlorīds, 1 000 mg tablete, glibenklamīds, 5 mg tablete
English: Metformin Hydrochloride 500mg/5 Ml
Latvian: Glucofolin metformīna hidrohlorīds, 500 mg/5 Ml
English: Bluefish Pharmaceuticals Ab
Latvian: Bluefish Pharmaceuticals Ab Metformine Bluefish
English: Metformin Hydrochloride 100mg/ Ml
Latvian: Metformin Focus Pharmaceuticals metformīna hidrohlorīds, 100 mg/Ml
English: Metformin Hcl Ratiopharm Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Latvian: Metformin Hcl Ratiopharm metformīna hidrohlorīds, 1 000 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Canagliflozin 150mg Tablet
Latvian: Vokanamet metformīna hidrohlorīds, 1 000 mg tablete, kanagliflozīns, 150 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Dapagliflozin 5mg Tablet
Latvian: Ebymect metformīna hidrohlorīds, 1 000 mg tablete, dapagliflozīns, 5 mg tablete
English: Estonia Sandoz Gmbh
Latvian: Sandoz Pharmaceuticals Gmbh
English: Consilient Health Limited
Latvian: Consilient Health Limited Glucient Sr
English: Metformin Hydrochloride 500mg Units
Latvian: Gluformin metformīna hidrohlorīds, 500 mg vienības
English: Metformin Hydrochloride 850mg Tablet, Dapagliflozin 5mg Tablet
Latvian: Ebymect metformīna hidrohlorīds, 850 mg tablete, dapagliflozīns, 5 mg tablete
English: Metformin-Ratiopharm Metformin Hydrochloride 850mg Tablet
Latvian: Metformin-Ratiopharm metformīna hidrohlorīds, 850 mg tablete
English: Metformin Bluefish
Latvian: Bluefish Pharmaceuticals Ab Metformin Bluefish
English: Metformin-Ratiopharm Metformin Hydrochloride 500mg Tablet
Latvian: Metformin-Ratiopharm metformīna hidrohlorīds, 500 mg tablete
English: Metformin Hydrochloride 850mg Tablet, Canagliflozin 50mg Tablet
Latvian: Vokanamet metformīna hidrohlorīds, 850 mg tablete, kanagliflozīns, 50 mg tablete
English: Metformin Hydrochloride 1000mg Tablet, Saxagliptin 2.5mg Tablet
Latvian: Komboglyze metformīna hidrohlorīds, 1 000 mg tablete, saksagliptīns, 2,5 mg tablete
English: Metformin Hydrochloride 850mg Tablet, Canagliflozin 150mg Tablet
Latvian: Vokanamet metformīna hidrohlorīds, 850 mg tablete, kanagliflozīns, 150 mg tablete
English: Metformin Hydrochloride 500mg Tablet, Glibenclamide 2.5mg Tablet
Latvian: Metformin Hexal metformīna hidrohlorīds, 500 mg tablete, glibenklamīds, 2,5 mg tablete
English: Metformin Hydrochloride 1000mg Tablet Tablet
Latvian: Metformina Mylan Generics metformīna hidrohlorīds, 1 000 mg tablete
English: Metformin Hydrochloride 400mg Tablet, Glibenclamide 5mg Tablet
Latvian: Glibomet metformīna hidrohlorīds, 400 mg tablete, glibenklamīds, 5 mg tablete
English: Metformin Hydrochloride 500mg
Latvian: Metformin Teva metformīna hidrohlorīds, 500 mg G
English: Metformin Hydrochloride 850mg Tablet, Saxagliptin 2.5mg Tablet
Latvian: Komboglyze metformīna hidrohlorīds, 850 mg tablete, saksagliptīns, 2,5 mg tablete
English: Germany Sandoz Pharmaceuticals Gmbh Metformin Sandoz
Latvian: Arcana Arzneimittel Gmbh Metformin Arcana
English: Metformina Bluefish
Latvian: Bluefish Pharmaceuticals Ab Metformina Bluefish
English: Denmark Aurobindo Pharma Limited
Latvian: Metformin Hydrochloride Aurobindo Pharma (Malta) Limited
English: Metformin Hydrochloride 500mg Tablet, Glibenclamide 5mg Tablet
Latvian: Metformin Hexal metformīna hidrohlorīds, 500 mg tablete, glibenklamīds, 5 mg tablete
English: Normell
Latvian: Norvēģija
English: Metformin Ratiopharm Metformin Hydrochloride 500mg Tablet
Latvian: Metformin Ratiopharm metformīna hidrohlorīds, 500 mg tablete
English: Metformin Ratiopharm Metformin Hydrochloride 850mg Tablet
Latvian: Metformin Ratiopharm metformīna hidrohlorīds, 850 mg tablete
English: Romania Wörwag Pharma Gmbh & Co. Kg Metfogamma
Latvian: Aurobindo Pharma Gmbh Metformin Aurobindo
English: Estonia Wörwag Pharma Gmbh & Co. Kg Metfogamma
Latvian: Hormosan Pharma Gmbh Metformin Hormosan
English: Wörwag Pharma Gmbh & Co. Kg Metfogamma
Latvian: Wörwag Pharma Gmbh & Co.
English: United Kingdom
Latvian: Nīderlande
English: Prolonged-Release Tablet
Latvian: Ilgstošās darbības tablete
English: Metformin Ratiopharm Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Latvian: Metformine Ratiopharm metformīna hidrohlorīds, 1 000 mg tablete
English: Metformin Lindopharm Metformin Hydrochloride 500mg Tablet
Latvian: Metformin Medley Pharma metformīna hidrohlorīds, 500 mg tablete
English: Metformin Hydrochloride 500mgg
Latvian: Metformina Azevedos metformīna hidrohlorīds, 500 mg membrāna
English: Metformin Lindopharm Metformin Hydrochloride 850mg Tablet
Latvian: Metformina Pensa Pharma metformīna hidrohlorīds, 850 mg tablete
English: It is available as capsules (100 mg).
Latvian: Tās ir pieejamas kā kapsulas (100 mg).
English: Some patients were treated for up to five and a half years.
Latvian: Dažus pacientus ārstēja līdz pat piecarpus gadiem.
English: • Gaucher disease;
Latvian: • Gošē slimība;
English: The main part of the study lasted for a year, but 13 patients carried on receiving the medicine for a further two years.
Latvian: Pētījuma galvenā daļa ilga vienu gadu, bet 13 pacienti turpināja saņemt zāles vēl divus gadus.
English: Zavesca is intended for long-term use.
Latvian: Zavesca ir paredzētas ilgstošai lietošanai.
English: There were also small improvements in blood counts: on average, the levels of haemoglobin increased by 0.26 g per decilitre and platelet counts increased by 8.29 million per millilitre.
Latvian: Novēroja arī nelielu asinsainas uzlabojumu: vidējais hemoglobīna koncentrācijas pieaugums bija 0,26 g uz decilitru, un trombocītu skaits pieauga par 8,29 miljoniem uz mililitru.
English: EPAR summary for the public miglustat
Latvian: EPAR kopsavilkums plašākai sabiedrībai miglustats
English: The European Commission granted a marketing authorisation valid throughout the European Union for Zavesca on 20 November 2002.
Latvian: Eiropas Komisija 2002. gada 20. novembrī izsniedza Zavesca reģistrācijas apliecību, kas derīga visā Eiropas Savienībā.
English: Other information about Zavesca:
Latvian: Cita informācija par Zavesca
English: Why has Zavesca been approved?
Latvian: Kāpēc Zavesca tika apstiprinātas?
English: As the company had supplied the additional information requested, the exceptional circumstances ended on 23 August 2012.
Latvian: 2012. gada 23. augustā, kad uzņēmums bija iesniedzis pieprasīto papildu informāciju, „izņēmuma kārta” tika atcelta.
English: The company also presented the results of a survey of 66 patients treated with Zavesca.
Latvian: Turklāt uzņēmums sniedza rezultātus, kas gūti pētījumā ar 66 pacientiem, kurus ārstēja ar Zavesca.
English: The full EPAR for Zavesca can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Latvian: Pilns Zavesca EPAR teksts ir atrodams aģentūras tīmekļa vietnē: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: The survey showed that Zavesca led to a stabilisation or a decrease in the rate at which symptoms got worse in about three-quarters of the patients.
Latvian: Apsekojums liecināja, ka Zavesca stabilizēja vai samazināja simptomu pasliktināšanās ātrumu apmēram trijām ceturtdaļām pacientu.
English: Zavesca was originally authorised under ‘exceptional circumstances' because, as the diseases are rare, limited information was available at the time of approval.
Latvian: Zavesca sākotnēji bija reģistrētas „izņēmuma kārtā”, jo sakarā ar slimību retumu apstiprināšanas brīdī nebija pieejama pilnīga informācija.
English: The main measure of effectiveness was the change in the speed at which the patients made saccadic horizontal eye movements after a year, but the study also looked at other neurological symptoms such as the patients' ability to swallow and their intellectual function.
Latvian: Galvenais efektivitātes rādītājs bija acu kustināšanas (horizontāli) ātruma izmaiņas pēc gada, bet pētījumā apskatīja arī citus neiroloģiskos simptomus, piemēram, pacientu rīšanas spēju un to garīgās spējas.
English: • Niemann-Pick type C disease.
Latvian: • Nīmana-Pika C tipa slimība
English: The summaries of the opinions of the Committee for Orphan Medicinal Products for Zavesca on the Agency's website ema.europa.eu/Find medicine/Human medicines/Rare disease designations:
Latvian: Retu slimību ārstēšanai paredzēto zāļu komitejas atzinuma kopsavilkums par Zavesca ir atrodams aģentūras tīmekļa vietnē ema.europa.eu/Find medicine/Human medicines/Rare disease designations:
English: This document is a summary of the European Public Assessment Report (EPAR) for Zavesca.
Latvian: Šis ir Eiropas Publiskā novērtējuma ziņojuma (EPAR) kopsavilkums par <X>.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Zavesca.
Latvian: Tajā ir paskaidrots, kā Cilvēkiem paredzēto zāļu komiteja (CHMP) novērtēja šīs zāles pirms sniegt pozitīvu atzinumu par reģistrācijas apliecības piešķiršanu un ieteikumus par Zavesca lietošanu.
English: In the study of Niemann-Pick type C disease, the improvement in eye movements was similar in patients treated with and without Zavesca.
Latvian: Nīmana-Pika (Niemann-Pick) C tipa slimības pētījumā acu kustību uzlabojumi bija līdzīgi pacientiem, kurus ārstēja ar un bez Zavesca.
English: Zavesca is a medicine that contains the active substance miglustat.
Latvian: Zavesca ir zāles, kas satur aktīvo vielu miglustatu.
English: The benefits of Zavesca were maintained over three years of continuous treatment.
Latvian: Pēc trīs gadu ilgas nepārtrauktas ārstēšanas Zavesca sniegtais ieguvums saglabājās.
English: Because the number of patients with these diseases is low, they are considered ‘rare', and Zavesca was designated an ‘orphan medicine' (a medicine used in rare diseases) on 18 October 2000 for type 1 Gaucher disease and on 16 February 2006 for Niemann-Pick type C disease.
Latvian: Tā kā šo slimību pacientu skaits ir mazs, tās uzskata par retām, un 2000. gada 18. oktobrī Zavesca apstiprināja kā zāles retu slimību ārstēšanai, proti - 1. tipa Gošē slimības ārstēšanai un 2006. gada 16. februārī - Nīmana-Pika (Niemann-Pick) C tipa slimības ārstēšanai.
English: In the study of type 1 Gaucher disease, there were moderate reductions in the size of the liver (12% reduction) and the spleen (19% reduction) after a year.
Latvian: Pētījumā ar 1. tipa Gošē slimību pēc gada bija novērots mērens aknu lieluma (12%) un liesas (19%) samazinājums.
English: What is the risk associated with Zavesca?
Latvian: Kāds risks pastāv, lietojot Zavesca?
English: The recommended starting dose for type 1 Gaucher disease is one capsule three times a day.
Latvian: Ieteicamā sākumdeva 1. tipa Gošē slimības ārstēšanai ir viena iekšķīgi lietojama kapsula trīs reizes dienā.
English: Zavesca is used to treat the following patients:
Latvian: Zavesca lieto, lai ārstētu šādus pacientus:
English: For further information, see the summary of product characteristics (also part of the EPAR).
Latvian: Papildu informācija atrodama zāļu aprakstā (kas arī ir daļa no EPAR).
English: Zavesca is used to treat two inherited diseases that affect the way the body handles fats.
Latvian: Zavesca lieto, lai ārstētu divas iedzimtas slimības, kas ietekmē veidu, kādā organisms pārstrādā taukus.
English: The study compared the effects of adding Zavesca to standard care with the effects of standard care alone.
Latvian: Pētījumā salīdzināja standarta aprūpes efektivitāti ar Zavesca un standarta aprūpes kombinācijas efektivitāti.
English: This is expected to slow down or prevent the development of the symptoms of type 1 Gaucher disease and to reduce the symptoms of Niemann-Pick type C disease.
Latvian: Šādi paredzēts palēnināt vai aizkavēt 1. tipa Gošē slimības simptomu attīstību un samazināt Nīmana-Pika (Niemann-Pick) C tipa slimības simptomus.
English: Zavesca must not be used in people who are hypersensitive (allergic) to miglustat or any of the other ingredients.
Latvian: Zavesca nedrīkst lietot cilvēki ar paaugstinātu jutību (alerģiju) pret miglustatu vai kādu citu šo zāļu sastāvdaļu.
English: For Niemann-Pick type C disease, it is two capsules three times a day for patients aged 12 years and over; in younger patients, the dose depends on their weight and height.
Latvian: Nīmana-Pika (Niemann-Pick) C tipa slimības gadījumā pacientiem no 12 gadu vecuma deva ir divas kapsulas trīs reizes dienā; jaunākiem pacientiem deva ir atkarīga no svara un auguma.
English: For more information about treatment with Zavesca, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Latvian: Plašāka informācija par ārstēšanu ar Zavesca pieejama zāļu lietošanas instrukcijā (kas arī ir EPAR daļa) vai, sazinoties ar ārstu vai farmaceitu.
English: The CHMP decided that Zavesca's benefits are greater than its risks and recommended that it be given marketing authorisation.
Latvian: CHMP nolēma, ka pacienta ieguvums, lietojot Zavesca, pārsniedz šo zāļu radīto risku, un ieteica izsniegt Zavesca reģistrācijas apliecību.
English: A lower dose should be used in patients with reduced kidney function.
Latvian: Pacientiem ar nieru darbības traucējumiem jālieto mazākas devas.
English: The dose should also be reduced temporarily in patients who develop diarrhoea.
Latvian: Deva uz laiku jāsamazina arī pacientiem, kuriem ir caureja.
English: Treatment with Zavesca should be started and monitored by doctors who are experienced in the management of Gaucher or Niemann-Pick type C disease.
Latvian: Ārstēšana ar Zavesca jāsāk un jāuzrauga ārstiem, kam ir pieredze Gošē vai Nīmana-Pika C tipa slimības ārstēšanā.
English: What is Zavesca?
Latvian: Kas ir Zavesca?
English: For Niemann-Pick type C disease, Zavesca was studied in one main study involving 31 patients, 12 of whom were less than 12 years old.
Latvian: Nīmana-Pika (Niemann-Pick) C tipa slimības gadījumā Zavseca efektivitāti pārbaudīja vienā pamatpētījumā, iesaistot 31 pacientu, no kuriem 12 bija jaunāki par 12 gadiem.
English: The study looked at the effect of Zavesca on the size of the liver and spleen, and at blood counts, such as the levels of haemoglobin (a protein found in red blood cells that carries oxygen around the body) and platelets (components that help the blood to clot).
Latvian: Pētījumā vērtēja, vai Zavesca ietekmē aknu un liesas izmērus un vai tās uzlabo asinsķermenīšu skaitu, piemēram, hemoglobīna (sarkanajos asinsķermenīšos esošo olbaltumvielu, kas organismā pārnēsā skābekli) koncentrāciju un trombocītu (asinsķermenīšu, kas veicina asins recēšanu) skaitu.
English: The most common side effects with Zavesca (seen in more than 1 patient in 10) are weight loss, decreased appetite, tremor (shaking), diarrhoea, flatulence (gas) and abdominal pain (stomach ache).
Latvian: Visbiežāk novērotās Zavesca blakusparādības (vairāk kā 1 pacientam no 10) ir svara samazināšanās, samazināta ēstgriba, trīce, caureja, meteorisms (gāzes) un sāpes vēderā.
English: By preventing the enzyme from working, miglustat can reduce the production of glycosphingolipids in cells.
Latvian: Kavējot fermenta darbību, miglustats var mazināt glikosfingolipīdu veidošanos šūnās.
English: This enzyme is involved in the first step of the production of glycosphingolipids.
Latvian: Šis ferments ir iesaistīts glikosfingolipīdu veidošanās pirmajā posmā.
English: What benefit has Zavesca shown during the studies?
Latvian: Kādas ir Zavesca priekšrocības šajos pētījumos?
English: However, there were signs of improvement in swallowing ability and intellectual function in the patients treated with Zavesca.
Latvian: Tomēr ar Zavesca ārstētajiem pacientiem uzlabojās rīšanas spēja un garīgās spējas.
English: Both diseases cause a build-up of fatty substances called glycosphingolipids in the body.
Latvian: Abu slimību rezultātā organismā uzkrājas taukvielas - glikosfingolipīdi.
English: For type 1 Gaucher disease, Zavesca was investigated in one main study involving 28 adults with mild to moderate disease who were unable or unwilling to receive ERT.
Latvian: Vāji līdz vidēji izteiktas 1. tipa Gošē slimības gadījumā Zavseca efektivitāti pārbaudīja vienā pamatpētījumā, iesaistot 28 pacientus, kas nevarēja vai nevēlējās saņemt ERT.
English: These include loss of co-ordination, problems with ‘saccadic' (rapid) eye movements that can lead to impaired vision, delayed development, difficulty swallowing, decreased muscle tone, fits and learning difficulties.
Latvian: • visu vecumu pacientus ar Nīmana-Pika (Niemann-Pick) C tipa slimību - potenciāli nāvējošu slimību, kuras gadījumā glikosfingolipīdi uzkrājas smadzeņu šūnās un citās organisma daļās; Zavesca lieto, lai ārstētu slimības „neiroloģiskos” simptomus (simptomus, kas ietekmē smadzenes un nervus) šie simptomi ietver koordinācijas zudumu, straujas acu kustības, kā rezultātā var rasties bojāta redze, kavēta attīstība, rīšanas grūtības, samazināts muskuļu tonuss, krampji un mācīšanās grūtības;
English: How does Zavesca work?
Latvian: Kā Zavesca darbojas?
English: The active substance in Zavesca, miglustat, prevents an enzyme called glucosylceramide synthase from working.
Latvian: Zavesca aktīvā viela miglustats kavē fermenta glikozilkeramīdsintāzes darbību.
English: For the full list of all side effects reported with Zavesca, see the package leaflet.
Latvian: Pilns visu Zavesca izraisīto blakusparādību saraksts ir atrodams zāļu lietošanas instrukcijā.
English: How has Zavesca been studied?
Latvian: Kā noritēja Zavesca izpēte?