FrancophonIA/ELRC3.0 huggingface dataset:
English: At the randomisation visit, which occurred 1 to 2 weeks later, the DRL was re-assessed and treatment with Selincro was initiated together with a psychosocial intervention (BRENDA) focused on treatment adherence and reduction of alcohol consumption.
Croatian: Pri randomizacijskom posjetu, koji se dogodio 1 do 2 tjedna kasnije, ponovno je procijenjen RPP i započeto je liječenje Selincrom, u kombinaciji s psihosocijalnom intervencijom (BRENDA), usmjerenom na pridržavanje liječenja i smanjenje konzumacije alkohola.
English: What Selincro looks like and contents of the pack
Croatian: Kako Selincro izgleda i sadržaj pakiranja
English: Few cases of side effects of seeing, hearing or sensing things that are not there or feeling detached from oneself have been reported.
Croatian: Prijavljeno je nekoliko slučajeva nuspojava kada su bolesnici vidjeli, čuli ili osjetili stvari kojih nema ili su se osjećali odvojenima od samih sebe.
English: The efficacy of Selincro in reducing alcohol consumption in patients with alcohol dependence (DSMIV) was evaluated in two efficacy studies.
Croatian: Djelotvornost Selincra u smanjenju konzumacije alkohola u bolesnika s ovisnošću o alkoholu (DSMIV) procijenjena je u dva ispitivanja djelotvornosti.
English: If Selincro is taken concomitantly with opioid agonists (for example, certain types of cough and cold medicinal products, certain antidiarrhoeal medicinal products, and opioid analgesics), the patient may not benefit from the opioid agonist.
Croatian: Ako se Selincro uzima istodobno s agonistima opioida (na primjer, određene vrste lijekova za kašalj i prehladu, određeni lijekovi protiv proljeva i opioidni analgetici), bolesnik možda neće imati koristi od agonista opioida.
English: The prescriber should advise patients that it is important to inform their health care professional of last Selincro intake if opioid use becomes necessary.
Croatian: Liječnik koji propisuje lijek treba savjetovati bolesnicima da je važno da obavijeste nadležne zdravstvene djelatnike kada su zadnji put uzeli Selincro, u slučaju da primjena opioida postane nužna.
English: Based on in vitro studies, no clinically relevant interactions between nalmefene, or its metabolites, and concomitantly administered medicinal products metabolised by the most common CYP450 and UGT enzymes or membrane transporters are anticipated.
Croatian: Na temelju in vitro ispitivanja, ne očekuju se klinički značajne interakcije između nalmefena ili njegovih metabolita i istodobno primijenjenih lijekova metaboliziranih najčešćim enzimima CYP450 i UGT ili membranskih prijenosnika.
English: Most of these adverse reactions resolved during continued treatment and did not recur upon repeated administration.
Croatian: Većina ovih nuspojava prestala je tijekom nastavka liječenja i nije se vratila nakon ponovljene primjene.
English: - The recommended dose is one tablet on days when you think there is a risk you will drink alcohol - The maximum dose is one tablet per day.
Croatian: - Preporučena doza je jedna tableta na dane kada mislite da postoji rizik da ćete piti alkohol.
English: Patients with current or recent opioid addiction.
Croatian: Bolesnici s trenutnom ili nedavnom ovisnošću o opioidima.
English: The film-coating of the tablet contains: hypromellose, macrogol 400, titanium dioxide (E171).
Croatian: Film ovojnica tablete sadrži: hipromelozu, makrogol 400, titanijev dioksid (E171).
English: Following oral administration, nalmefene undergoes extensive, rapid metabolism to the major metabolite nalmefene 3-O-glucuronide, with the UGT2B7 enzyme being primarily responsible for the conversion, and with the UGT1A3 and UGT1A8 enzymes as minor contributors.
Croatian: Nakon oralne primjene nalmefen prolazi kroz opsežni, brzi metabolizam do glavnog metabolita nalmefen 3-O-glukuronida, s tim da je enzim UGT2B7 primarno odgovoran za ovu pretvorbu, dok enzimi UGT1A3 i UGT1A8 doprinose manje.
English: Angioedema Urticaria Pruritus Rash
Croatian: Angioedem Urtikarija Pruritus Osip
English: Caution should be excercised when taking medicines such as diclofenac (antiinflammatory medicine used to treat, for example, muscle pain), fluconazole (antibiotic used to treat diseases caused by some types of fungus), omeprazole (medicine used to block the production of acid in the stomach), or rifampicin (antibiotic used to treat diseases caused by some types of bacteria) together with Selincro.
Croatian: Potreban je oprez kada se uzimaju lijekovi poput diklofenaka (protuupalni lijek koji se koristi u liječenju, na primjer, bola u mišićima), flukonazol (antibiotik koji se koristi u liječenju bolesti uzrokovane nekim vrstama gljivica), omeprazol (lijek koji se koristi za zaustavljanje stvaranja kiseline u želucu) ili rifampicin (antibiotik koji se koristi za liječenje bolesti uzrokovanih nekim vrstama bakterija) zajedno sa Selincrom.
English: Selincro is indicated for the reduction of alcohol consumption in adult patients with alcohol dependence who have a high drinking risk level (DRL) [see section 5.1], without physical withdrawal symptoms and who do not require immediate detoxification.
Croatian: Selincro je indiciran za smanjenje konzumacije alkohola u odraslih bolesnika s ovisnošću o alkoholu koji imaju visoku razinu rizika od prekomjernog pijenja (RPP) [vidjeti dio 5.1], bez simptoma fizičkog ustezanja te kojima nije potrebna trenutna detoksikacija.
English: In a study in patients diagnosed with pathological gambling, doses of nalmefene up to 90 mg/day for 16 weeks were investigated.
Croatian: U ispitivanju na bolesnicima s dijagnosticiranim patološkim kockanjem, ispitivane su doze nalmefena do 90 mg/dan tijekom 16 tjedana.
English: Nalmefene Odds Ratio (95% CI) p-value
Croatian: Nalmefen Omjer šansi (95% CI)
English: Further, the Cmax and elimination half-life for nalmefene was up to 1.6 times higher in patients with severe renal impairment.
Croatian: Nadalje, Cmax i poluvijek eliminacije za nalmefen bio je do 1,6 puta viši u bolesnika s teškim oštećenjem bubrega.
English: Nalmefene exhibits a dose-independent linear pharmacokinetic profile in the dose interval of 18.06 mg to 72.24 mg, with a 4.4 times increase in Cmax and a 4.3 times increase in AUC0-tau (at or near steady state).
Croatian: Nalmefen pokazuje linearni farmakokinetički profil neovisan o dozi u doznim intervalima od 18,06 mg do 72,24 mg, s povećanjem od 4,4 puta u Cmax i povećanjem od 4,3 puta u AUC0-tau (pri ili blizu stanja dinamičke ravnoteže).
English: The clinical efficacy and the clinical relevance of Selincro were analysed in patients with a high or very high DRL at screening and randomisation.
Croatian: Klinička djelotvornost i klinički značaj Selincra analizirani su u bolesnika s visokim ili vrlo visokim RPP-om pri probiru i randomizaciji.
English: Vomiting Dry mouth Diarrhoea
Croatian: Povraćanje Suha usta Proljev
English: Available pharmacodynamic/toxicological data in animals have shown excretion of nalmefene/metabolites in milk (see section 5.3).
Croatian: Dostupni farmakodinamički/toksikološki podatci u životinja pokazuju da se nalmefen/metaboliti izlučuju u mlijeko (vidjeti dio 5.3).
English: For the inactive major metabolite nalmefene 3-O-glucuronide, the AUC and Cmax were up to 5.1 times and 1.8 times higher in patients with severe renal impairment, respectively (see sections 4.3 and 4.4).
Croatian: Za neaktivni glavni metabolit nalmefen 3-O-glukuronid, AUC i Cmax bili su do 5,1 puta odnosno 1,8 puta viši u bolesnika s teškim oštećenjem bubrega (vidjeti dijelove 4.3 i 4.4).
English: Selincro is used for the reduction of alcohol consumption in adult patients with alcohol dependence who still have a high level of alcohol consumption 2 weeks after the first consultation with their doctor.
Croatian: Selincro se koristi za smanjenje konzumacije alkohola u odraslih bolesnika s ovisnošću o alkoholu koji još uvijek imaju visoki rizik od konzumacije alkohola 2 tjedna nakon prvog savjetovanja s liječnikom.
English: In a rabbit embryo-foetal developmental toxicity study, effects on foetuses in terms of reduced foetal weight and delayed ossification, but no major abnormalities were seen.
Croatian: U ispitivanju toksičnosti na embrio-fetalni razvoj kod kunića, opaženi su učinci u smislu smanjene tjelesne težine fetusa i odgođene osifikacije, ali bez većih abnormalnosti.
English: a Analysis treats patients who withdrew as non-responder b ≥70% reduction from baseline in TAC at Month 6 (28-day period) c 0 to 4 HDDs/month at Month 6 (28-day period)
Croatian: a Analiza tretira bolesnike koji su odustali kao one koji nisu odgovorili na liječenje b ≥70% smanjenje od početne vrijednosti u UKA u 6. mjesecu (28-dnevno razdoblje) c 0 do 4 DTPP-a/mjesec u 6. mjesecu (28-dnevno razdoblje)
English: Studies in rats have shown excretion of nalmefene or its metabolites in milk.
Croatian: Ispitivanja na štakorima pokazala su da se nalmefen ili njegovi metaboliti izlučuju u mlijeko.
English: Caution should be exercised when using medicinal products containing opioids (for example, cough medicines, opioid analgesics (see section 4.5)).
Croatian: Potreban je oprez kada se primjenjuju lijekovi koji sadrže opioide (na primjer, lijekovi protiv kašlja, opioidni analgetici) (vidjeti dio 4.5)).
English: In fertility studies in rats, no effects were observed for nalmefene on fertility, mating, pregnancy, or sperm parameters.
Croatian: U ispitivanjima plodnosti kod štakora nisu opaženi učinci nalmefena na plodnost, parenje, trudnoću ili parametre sperme.
English: The film-coated tablet should not be divided or crushed because nalmefene may cause skin sensitisation when in direct contact with the skin (see section 5.3).
Croatian: Filmom obložene tablete se ne smiju razdjeljivati ili lomiti jer nalmefen može prouzročiti osjetljivost kože kada je u izravnom kontaktu s kožom (vidjeti dio 5.3).
English: Occupancy data obtained in a PET study after single and repeated daily dosing with 18.06 mg nalmefene show 94% to 100% receptor occupancy within 3 hours after dosing, which suggests that nalmefene readily crosses the blood-brain barrier.
Croatian: Podaci o zaokupljenosti dobiveni u PET ispitivanju nakon pojedinačnog i ponovljenog dnevnog doziranja s 18,06 mg nalmefena pokazuju 94% do 100% zaokupljenosti receptora unutar 3 sata nakon doziranja, što upućuje na to da nalmefen lako prolazi krvno-moždanu barijeru.
English: The frequencies of the adverse reactions in Table 1 were calculated based on three randomised, double-blind, placebo-controlled studies in patients with alcohol dependence.
Croatian: Učestalosti nuspojava u Tablici 1 izračunate su na temelju tri randomizirana, dvostruko slijepa, placebom kontrolirana ispitivanja u bolesnika s ovisnošću o alkoholu.
English: At the next visit, Selincro may be initiated in patients who continued to have a high DRL (see section 5.1) over this two-week period, in conjunction with psychosocial intervention focused on treatment adherence and reducing alcohol consumption.
Croatian: Pri idućem posjetu može se započeti liječenje Selincrom u bolesnika koji su nastavili imati visoki RPP (vidjeti dio 5.1) tijekom ovog dvotjednog razdoblja, u kombinaciji s psihosocijalnom intervencijom usmjerenom na pridržavanje liječenja i smanjenje konzumacije alkohola.
English: The efficacy of Selincro was measured using two co-primary endpoints: the change from baseline to Month 6 in the monthly number of heavy drinking days (HDDs) and the change from baseline to Month 6 in the daily total alcohol consumption (TAC).
Croatian: Djelotvornost Selincra mjerena je pomoću dva koprimarna ishoda: promjena u mjesečnom broju dana teškog prekomjernog pijenja alkohola (DTPP) od početnih vrijednosti do 6. mjeseca i promjena dnevne ukupne konzumacije alkohola (UKA) od početnih vrijednosti do 6. mjeseca.
English: - Each film-coated tablet contains 18.06 milligram nalmefene (as hydrochloride dihydrate) - The other ingredients are:
Croatian: - Svaka filmom obložena tableta sadrži 18,06 miligrama nalmefena (u obliku nalmefenklorid dihidrata) - Drugi sastojci su:
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke šećere, obratite se svom liječniku prije nego što uzmete ovaj lijek.
English: - In vitro studies have demonstrated that nalmefene is a selective opioid receptor ligand with antagonist activity at the μ and δ receptors and partial agonist activity at the κ receptor.
Croatian: - In vitro ispitivanja pokazala su da je nalmefen selektivni ligand opiodnog receptora s antagonističkim djelovanjem na receptore μ i δ i djelomičnim agonističkim djelovanjem na receptor κ.
English: What you need to know before you take Selincro
Croatian: Što morate znati prije nego počnete uzimati Selincro
English: It is unknown whether nalmefene is excreted in human milk.
Croatian: Nije poznato izlučuje li se nalmefen u majčino mlijeko u ljudi.
English: The oral clearance of nalmefene (CL/F) was estimated as 169 l/h and the terminal half-life was estimated as 12.5 hours.
Croatian: Oralni klirens nalmefena (CL/F) procijenjen je na 169 l/h, a poluvijek je procijenjen na 12,5 sati.
English: As concerns the patients with high or very high DRL at baseline, 35% of patients experienced improvement due to non-pharmacological effects in the period between the initial visit (screening) and randomisation.
Croatian: Od bolesnika s visokim ili vrlo visokim RPP-om pri početnim vrijednostima, 35% bolesnika iskusilo je poboljšanje zbog nefarmakoloških učinaka u razdoblju između početnog posjeta (probir) i randomizacije.
English: A study with IV administration suggested that there were no relevant changes in the pharmacokinetics in the elderly as compared to non-elderly adults (see sections 4.2 and 4.4).
Croatian: Ispitivanje s intravenskom primjenom upućuje na to da nije bilo relevantnih promjena u farmakokinetici u starijih osoba u usporedbi s drugim odraslim osobama (vidjeti dijelove 4.2 i 4.4).
English: Nornalmefene is further converted to nornalmefene 3-O-glucuronide and nornalmefene 3O-sulphate.
Croatian: Nornalmefen se dalje pretvara u nornalmefen 3-O-glukuronid i nornalmefen 3-O-sulfat.
English: Co-administration with medicinal products that are potent inhibitors of the UGT2B7 enzyme (for example, diclofenac, fluconazole, medroxyprogesterone acetate, meclofenamic acid) may significantly increase the exposure to nalmefene.
Croatian: Istodobna primjena lijekova koji su snažni inhibitori enzima UGT2B7 (na primjer, diklofenak, flukonazol, medroksiprogesteronacetat, meklofenamatna kiselina) može značajno povećati izloženost nalmefenu.
English: The most common adverse reactions were nausea, dizziness, insomnia, and headache.
Croatian: Najčešće nuspojave bile su mučnina, omaglica, nesanica i glavobolja.
English: Selincro does not prevent the intoxicating effects of alcohol.
Croatian: Selincro ne sprječava opojne učinke alkohola.
English: The patient should be closely monitored for symptoms of respiratory depression as a result of the opioid administration and for other adverse reactions.
Croatian: Bolesnika treba pomno nadzirati zbog moguće pojave simptoma respiratorne depresije kao rezultata primjene opioida, kao i drugih nuspojava.
English: You may experience acute opioid withdrawal symptoms (such as feeling sick, vomiting, shakiness, sweating and anxiety) - if you experience, or suspect you are experiencing opioid withdrawal symptoms - if your liver or kidney function is poor - if you are experiencing or have recently experienced several alcohol withdrawal symptoms
Croatian: Možda ćete iskusiti akutne simptome ustezanja od opioida (kao što su mučnina, povraćanje, drhtanje, znojenje i tjeskoba) - ako iskusite, ili sumnjate da doživljavate simptome ustezanja od opioida - ako imate lošu funkciju bubrega ili jetre - ako doživljavate, ili ste nedavno iskusili nekoliko simptoma ustezanja od alkohola (primjerice,
English: At the initial visit, the patients' clinical status, social situation, and alcohol consumption pattern were evaluated (based on patient reporting).
Croatian: Pri početnom posjetu procjenjivani su bolesnikov klinički status, socijalna situacija i obrazac konzumacije alkohola (na temelju bolesnikova izvješća).
English: Nalmefene is rapidly absorbed after a single oral administration of 18.06 mg, with a peak concentration (Cmax) of 16.5 ng/ml after approximately 1.5 hours and an exposure (AUC) of 131 ng*h/ml.
Croatian: Nalmefen se brzo apsorbira nakon oralne primjene pojedinačne doze od 18,06 mg, s vršnim koncentracijama (Cmax) od 16,5 ng/ml nakon približno 1,5 sati i pri izloženosti (AUC) od 131 ng*h/ml.
English: Nalmefene is an opioid system modulator with a distinct μ, δ, and κ receptor profile.
Croatian: Nalmefen je modulator opioidnog sustava s posebnim profilom receptora μ, δ, i κ.
English: In patients with moderate hepatic impairment, exposure increased 2.9 times for AUC and 1.7 times for Cmax, while oral clearance decreased by approximately 60%.
Croatian: U bolesnika s umjerenim oštećenjem jetre izloženost se povećala 2,9 puta za AUC i 1,7 puta za Cmax, dok se oralni klirens smanjio za približno 60%.
English: Patients taking opioid agonists (such as opioid analgesics, opioids for substitution therapy with opioid agonists (e.g. methadone) or partial agonists (e.g. buprenorphine)) (see section 4.4).
Croatian: Bolesnici koji uzimaju agoniste opioida (kao što su opioidni analgetici, opioidi za nadomjesno liječenje s agonistima opioida (npr. metadon) ili parcijalni agonisti (npr. buprenorfin)) (vidjeti dio 4.4).
English: Therefore, caution should be exercised when prescribing Selincro to patients with mild or moderate hepatic or mild or moderate renal impairment, for example, by more frequent monitoring.
Croatian: Stoga je potreban oprez kada se Selincro propisuje bolesnicima s blagim ili umjerenim oštećenjem jetre ili blagim ili umjerenim oštećenjem bubrega, na primjer, putem češćeg nadziranja.
English: In a study in patients with interstitial cystitis, 20 patients received 108 mg/day of nalmefene for more than 2 years.
Croatian: U ispitivanju na bolesnicima s intersticijskim cistitisom, 20 bolesnika primalo je 108 mg/dan nalmefena tijekom više od 2 godine.
English: Table 2 Pooled Responder Analysis Results in Patients with a High or Very High DRL at screening and Randomisation
Croatian: Tablica 2 Rezultati udruženih analiza odgovora u bolesnika s visokim ili vrlo visokim RPP-om pri probiru i randomizaciji
English: It is not known if Selincro is safe to use during pregnancy and breast-feeding.
Croatian: Nije poznato je li sigurno uzimati Selincro tijekom trudnoće i dojenja.
English: H. Lundbeck A/S
Croatian: Lundbeck A/S
English: Film-coated tablet (tablet) White, oval, biconvex, 6.0 x 8.75 mm film-coated tablet engraved with “S” on one side
Croatian: Bijela, ovalna, bikonveksna filmom obložena tableta veličine 6,0 x 8,75 mm s ugraviranim “S” na jednoj strani
English: For patients with mild, moderate or severe renal impairment the AUC for nalmefene was 1.1 times, 1.4 times and 2.4 times higher, respectively.
Croatian: Za bolesnike s blagim, umjerenim ili teškim oštećenjem bubrega, AUC za nalmefen bio je viši 1,1 puta, 1,4 puta odnosno 2,4 puta.
English: What Selincro contains
Croatian: Što Selincro sadrži
English: Each film-coated tablet contains 18.06 mg nalmefene (as hydrochloride dihydrate).
Croatian: Svaka filmom obložena tableta sadrži 18,06 mg nalmefena (u obliku nalmefenklorid dihidrata).
English: Other side effects (cannot be estimated from the available data) - seeing, hearing or sensing things that are not there - feeling detached from oneself - swelling of face, lips, tongue or throat - hives - itching - rash - redness of skin - muscle pain - prolonged erection (priapism)
Croatian: Ostale nuspojave (ne može se procijeniti iz dostupnih podataka) - možete vidjeti, čuti ili osjetiti stvari kojih nema - osjećaj odvojenosti od samog sebe - oticanje lica, usana, jezika ili grla - koprivnjača - svrbež - osip - crvenilo kože - bolovi u mišićima - produljena erekcija (prijapizam).
English: The safety and efficacy of Selincro in children and adolescents <18 years of age have not been established.
Croatian: Sigurnost i djelotvornost Selincra u djece i adolescenata u dobi
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Selincro therapy, taking into account the benefit of breast-feeding to the child and the benefit of therapy to the woman.
Croatian: Potrebno je odlučiti da li prekinuti dojenje ili prekinuti liječenje/suzdržati se od liječenja lijekom Selincro uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: If the patient has started drinking alcohol without taking Selincro, the patient should take one tablet as soon as possible.
Croatian: Ako je bolesnik počeo piti alkohol bez uzimanja Selincra, treba uzeti jednu tabletu što je prije moguće.
English: Selincro contains lactose
Croatian: Selincro sadrži laktozu
English: Selincro is not for patients for whom the treatment goal is immediate abstinence.
Croatian: Selincro nije namijenjen bolesnicima kojima je cilj liječenja trenutna apstinencija.
English: Conversely, concomitant administration with a UGT inducer (for example, dexamethasone, phenobarbital, rifampicin, omeprazole) may potentially lead to subtherapeutic nalmefene plasma concentrations.
Croatian: Obrnuto, istodobna primjena induktora UGT-a (na primjer, deksametazon, fenobarbital, rifampicin, omeprazol) može potencijalno voditi do supterapijskih plazmatskih koncentracija nalmefena.
English: An increase in still-born pups and decrease in post-natal viability of pups was observed in prepostnatal toxicity studies in rats.
Croatian: Opaženo je povećanje broja mrtvorođene mladunčadi i smanjenje postnatalne životne aktivnosti u prepostnatalnim ispitivanjima toksičnosti u štakora.
English: If you are 65 years old or above, talk to your doctor or pharmacist before taking Selincro.
Croatian: Ako imate 65 godina ili više, obratite se svom liječniku ili ljekarniku prije nego uzmete ovaj lijek.
English: Elderly (≥65 years of age) No dose adjustment is recommended for this patient population (see sections 4.4 and 5.2).
Croatian: Stariji (≥65 godina) Nije preporučena prilagodba doze u ovoj populaciji bolesnika (vidjeti dijelove 4.4 i 5.2).
English: If you are breast-feeding, you and your doctor should make a decision whether to discontinue breastfeeding or to discontinue Selincro therapy, taking into account the benefit of breast-feeding to the child and the benefit of therapy to you.
Croatian: Ako dojite, Vi i Vaš liječnik biste trebali odlučiti hoćete li prekinuti s dojenjem ili ćete prekinuti terapiju Selincrom, uzimajući u obzir korist dojenja za dijete i korist terapije za Vas.
English: In patients with mild hepatic impairment, exposure increased 1.5 times and oral clearance decreased by approximately 35%.
Croatian: U bolesnika s blagim oštećenjem jetre izloženost se povećala 1,5 puta, a oralni klirens se smanjio za približno 35%.
English: Tachycardia Palpitations
Croatian: Tahikardija Palpitacije
English: Adverse reactions such as disturbance in attention, feeling abnormal, nausea, dizziness, somnolence, insomnia, and headache may occur following administration of nalmefene (see section 4.8).
Croatian: Nuspojave kao što su poremećaj pažnje, osjećaj abnormalnosti, mučnina, omaglica, somnolencija, nesanica i glavobolja mogu se javiti nakon primjene nalmefena (vidjeti dio 4.8).
English: No in vivo drug-drug interaction studies have been conducted.
Croatian: Nisu provedena in vivo ispitivanja interakcija s drugim lijekovima.
English: At an initial visit, the patient's clinical status, alcohol dependence, and level of alcohol consumption (based on patient reporting) should be evaluated.
Croatian: Za vrijeme prvog posjeta trebalo bi procijeniti bolesnikov klinički status, ovisnost o alkoholu te razinu konzumacije alkohola (na temelju bolesnikova izvješća).
English: A small proportion of nalmefene is converted to nalmefene 3-O-sulphate by sulphation and to nornalmefene by CYP3A4/5.
Croatian: Mali dio nalmefena pretvara se sulfatizacijom u nalmefen 3-O-sulfat i u nornalmefen pomoću CYP3A4/5.