FrancophonIA/ELRC3.0 huggingface dataset:
English: ▪ primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic generalised epilepsy (the type of epilepsy that is thought to have a genetic cause).
Croatian: ▪ miokloničkih napadaja (kratki, iznenadni trzaji mišića ili skupine mišića) u odraslih i adolescenata starijih od 12. godine života s juvenilnom miokloničkom epilepsijom ▪ primarno generaliziranih toničko-kloničkih napadaja (veliki napadaji, dovode do gubitka svijesti) u odraslih i adolescenata starijih od 12. godine života s idiopatskom generaliziranom epilepsijom (oblik epilepsije za koju se smatra da je genetski uvjetovana).
English: One vial contains 500 mg/5 ml levetiracetam.
Croatian: TVARI Jedna bočica sadrži 500 mg/5 ml levetiracetama.
English: Box of 20, 30, 50, 60, 80, 100, 100 (100 x 1)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Kutija od 20, 30, 50, 60, 80, 100, 100 (100 x 1) tableta
English: − If you get any side effects talk to your doctor or pharmacist.
Croatian: - Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
English: Silica colloidal anhydrous Magnesium stearate
Croatian: Jezgra tablete karmelozanatrij, umrežena makrogol 6000 silicijev dioksid, koloidni, bezvodni magnezijev stearat
English: Starting dose: 0.07 ml/kg twice daily Maximum dose: 0.21 ml/kg twice daily
Croatian: Najveća doza: 0,21 ml/kg dva puta na dan
English: Box of 10, 20, 30, 50, 60, 100, 100 (100 x 1)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Kutija od 10, 20, 30, 50, 60, 100, 100 (100 x 1) tableta
English: Aluminium/PVC blisters placed into cardboard boxes containing 20, 30, 50, 60, 80, 100 film-coated tablets and multipacks containing 200 (2 packs of 100) film-coated tablets.
Croatian: Aluminij/PVC blisteri umetnuti u kartonske kutije koje sadrže 20, 30, 50, 60, 80, 100 filmom obloženih tableta i višestruka pakiranja koja sadrže 200 (2 pakiranja od 100) filmom obloženih tableta.
English: 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 60 film-coated tablets 80 film-coated tablets 100 film-coated tablets 100 x 1 film-coated tablets
Croatian: 20 filmom obloženih tableta 30 filmom obloženih tableta 50 filmom obloženih tableta 60 filmom obloženih tableta 80 filmom obloženih tableta 100 filmom obloženih tableta 100 x 1 filmom obloženih tableta
English: This is related to the decrease in renal function in this population (see section 4.2).
Croatian: U starijih osoba poluvijek u plazmi povećano je za oko 40% (10 do 11 sati), što je u svezi sa smanjenjem bubrežne funkcije unutar te populacije (vidjeti dio 4.2 ).
English: 10 film-coated tablets 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 60 film-coated tablets 100 film-coated tablets 100 x 1 film-coated tablets
Croatian: 10 filmom obloženih tableta 20 filmom obloženih tableta 30 filmom obloženih tableta 50 filmom obloženih tableta 60 filmom obloženih tableta 100 filmom obloženih tableta 100 x 1 filmom obloženih tableta
English: 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 60 film-coated tablets 100 film-coated tablets 100 x 1 film-coated tablets
Croatian: 20 filmom obloženih tableta 30 filmom obloženih tableta 50 filmom obloženih tableta 60 filmom obloženih tableta 100 filmom obloženih tableta 100 x 1 filmom obloženih tableta
English: Aluminium/PVC blisters placed into cardboard boxes containing 10, 20, 30, 50, 60, 100 film-coated tablets and multipacks containing 200 (2 packs of 100) film-coated tablets.
Croatian: Aluminij/PVC blisteri umetnuti u kartonske kutije koje sadrže 10, 20, 30, 50, 60, 100 filmom obloženih tableta i višestruka pakiranja koja sadrže 200 (2 pakiranja od 100) filmom obloženih tableta.
English: Aluminium/PVC blisters placed into cardboard boxes containing 20, 30, 50, 60, 100 film-coated tablets and multipacks containing 200 (2 packs of 100) film-coated tablets.
Croatian: Aluminij/PVC blisteri umetnuti u kartonske kutije koje sadrže 20, 30, 50, 60, 100 filmom obloženih tableta i višestruka pakiranja koja sadrže 200 (2 pakiranja od 100) filmom obloženih tableta.
English: 2 spray containers
Croatian: 2 Spremnike spreja
English: 1.8 mg Nasal spray, solution Nasal use vial (glass)
Croatian: 1.8 mg sprej za nos, otopina
English: No special requirements
Croatian: Nema posebnih zahtijeva
English: These may be the signs of an allergic reaction.
Croatian: Ovi simptomi mogu biti znakovi alergijske reakcije.
English: Hallucinations, confusion
Croatian: Halucinacije, konfuzija
English: 61700 Brno Czech Republic
Croatian: 61700 Brno
English: Date of latest renewal: 22 May 2014
Croatian: Datum posljednje obnove odobrenja: 22.05.2014.
English: Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks.
Croatian: Kombinirano liječenje treba započeti što je ranije moguće nakon pojave simptoma i nastaviti kroz najmanje 4
English: Other medicinal products:
Croatian: Ostali lijekovi:
English: The application is based on a reference medicinal product for which no safety concerns requiring additional risk minimisation activities have been identified.
Croatian: Zahtjev se temelji na referentnom lijeku za koji nisu potrebne sigurnosne mjere za dodatnu minimizaciju rizika.
English: If you are allergic to clopidogrel or any of the other ingredients of this medicine (listed in section 6).
Croatian: • Ako ste alergični (preosjetljivi) na klopidogrel ili na neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: If you suffer from severe liver disease.
Croatian: • Ako patite od teške bolesti jetre.
English: Macrogol 6000
Croatian: Jezgra tablete: makrogol 6000
English: You should tell your doctor if a surgery (including dental) is planned.
Croatian: • Obavijestite svog liječnika ako planirate kirurški zahvat (uključujući stomatološke zahvate).
English: The MAH must ensure that the system of pharmacovigilance, presented in Module 1.8.1. of the Marketing Authorisation, is in place and functioning before and whilst the product is on the market.
Croatian: Nositelj odobrenja mora osigurati da je farmakovigilancijski sustav, prikazan u Modulu 1.8.1. odobrenja za stavljanje gotovog lijeka u promet, ustrojen i funkcionalan prije i za vrijeme dok je lijek na tržištu.
English: Clopidogrel is indicated in adults for the secondary prevention of atherothrombotic events in:
Croatian: Klopidogrel je indiciran kod odraslih za sekundarnu prevenciju aterotrombotičkih događaja u:
English: If a patient is to undergo elective surgery and antiplatelet effect is temporarily not desirable, clopidogrel should be discontinued 7 days prior to surgery.
Croatian: Ako se bolesnik planira podvrgnuti elektivnom kirurškom zahvatu pa antitrombocitni učinak trenutno nije poželjan, davanje klopidogrela treba prekinuti 7 dana prije zahvata.
English: Clopidogrel has been evaluated for safety in more than 42,000 patients who have participated in clinical studies, including over 9,000 patients treated for 1 year or more.
Croatian: Sigurnost primjene klopidogrela ispitana je na više od 42 000 bolesnika koji su sudjelovali u kliničkim ispitivanjima, uključujući više od 9000 bolesnika koji su lijek primali godinu ili više dana.
English: Their frequency is defined using the following conventions: common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000); not known (cannot be estimated from the available data).
Croatian: <1/100); rijetke (≥1/10 000, <1/1000); vrlo rijetke (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: A number of other clinical studies have been conducted with clopidogrel and other concomitant medicinal products to investigate the potential for pharmacodynamic and pharmacokinetic interactions.
Croatian: Određeni broj ostalih kliničkih studija provodio se s klopidogrelom i nekim drugim istodobno primjenjivanim lijekovima kako bi se ispitala mogućnost farmakodinamičkih i farmakokinetičkih interakcija.
English: Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu/
Croatian: Detaljne informacije o ovom lijeku dostupne su na intenetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu/.
English: Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake „EXP “.
English: In CURE, 823 (6.6%) patients received concomitant GPIIb/IIIa receptor antagonist therapy.
Croatian: U studiji CURE 823 (6,6%) bolesnika istodobno je primalo antagoniste receptora GPIIb/IIIa.
English: Neutropenia, including severe neutropenia
Croatian: uključujući tešku neutropeniju
English: White to off-white, marbled, round and biconvex film-coated tablets.
Croatian: Bijele do gotovo bijele, mramorne, okrugle i bikonveksne filmom obložene tablete.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 28 July 2009
Croatian: Datum prvog odobrenja: 28.07.2009.
English: 7 film-coated tablets 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 50 film-coated tablets 84 film-coated tablets 90 film-coated tablets 100 film-coated tablets
Croatian: 7 filmom obloženih tableta 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 50 filmom obloženih tableta 84 filmom obložene tablete 90 filmom obloženih tableta 100 filmom obloženih tableta
English: The other ingredients are (see section 2 ‘Clopidogrel ratiopharm GmbH contains hydrogenated castor oil'):
Croatian: Drugi sastojci su (vidjeti dio 2. „Klopidogrel ratiopharm GmbH sadrži hidrogenirano ricinusovo ulje“)::
English: Your doctor may order blood tests.
Croatian: • Vaš liječnik će možda odrediti da Vam se naprave pretrage krvi.
English: This may cause stomach upset or diarrhoea.
Croatian: To može uzrokovati želučane tegobe ili proljev.
English: Bleeding at puncture site
Croatian: Krvarenje na mjestu punkcije
English: Alu/Alu blisters containing 7, 14, 28, 30, 50, 84, 90 and 100 film-coated tablets packed in cardboard cartons.
Croatian: Al/Al blisteri, koji sadrže 7, 14, 28, 30, 50, 84, 90 i 100 filmom obloženih tableta, pakirani u kartonske kutije.
English: It is preferable not to take this product during pregnancy.
Croatian: Ne preporučuje se uzimanje ovog lijeka za vrijeme trudnoće.
English: If you have a medical condition that is currently causing bleeding such as a stomach ulcer or bleeding within the brain.
Croatian: • Ako imate poremećaj koji trenutno izaziva krvarenje, kao što je, primjerice, želučani čir ili krvarenje u mozgu.
English: Rash, pruritus, skin bleeding (purpura)
Croatian: Osip, svrbež, krvarenja na koži (purpura)
English: EU/1/09/541/001 - 14 film-coated tablets EU/1/09/541/002 - 28 film-coated tablets EU/1/09/541/003 - 30 film-coated tablets EU/1/09/541/004 - 50 film-coated tablets EU/1/09/541/005 - 84 film-coated tablets EU/1/09/541/006 - 90 film-coated tablets EU/1/09/541/007 - 100 film-coated tablets EU/1/09/541/008 - 7 film-coated tablets
Croatian: EU/1/09/541/001 - 14 filmom obloženih tableta EU/1/09/541/002 - 28 filmom obloženih tableta EU/1/09/541/003 - 30 filmom obloženih tableta EU/1/09/541/004 - 50 filmom obloženih tableta EU/1/09/541/005 - 84 filmom obloženih tableta EU/1/09/541/006 - 90 filmom obloženih tableta EU/1/09/541/007 - 100 filmom obloženih tableta EU/1/09/541/008 - 7 filmom obloženih tableta
English: If you have experienced severe chest pain (unstable angina or heart attack), your doctor may give you 300 mg of Clopidogrel ratiopharm GmbH (4 tablets of 75 mg) once at the start of treatment.
Croatian: Ako ste imali jake bolove u prsištu (nestabilna angina ili srčani udar), liječnik Vam u početku liječenja može jednokratno dati 300 mg Klopidogrel ratiopharm GmbH (4 tablete od 75 mg).
English: A total of 99.7% of patients received fibrinolytics (fibrin specific: 68.7%, non-fibrin specific: 31.1%), 89.5% heparin, 78.7% beta blockers, 54.7% ACE inhibitors and 63% statins.
Croatian: Fibrinolitike je primalo 99,7% bolesnika (fibrin-specifični: 68,7%, fibrin-nespecifični: 31,1%), 89,5% heparin, 78,7% beta blokatore, 54,7% ACE inhibitore i 63%
English: Intracranial bleeding (some cases were reported with fatal outcome), headache, paraesthesia, dizziness
Croatian: Intrakranijalno krvarenje (prijavljeni su neki slučajevi s fatalnim ishodom) glavobolja, parestezija, omaglica
English: Contains hydrogenated castor oil.
Croatian: Sadrži hidrogenirano ricinusovo ulje.
English: - For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.
Croatian: Ako je prošlo više od 12 sati: bolesnik treba sljedeću dozu uzeti prema uobičajenom rasporedu i ne smije uzeti dvostruku dozu.
English: Some other medicines may influence the use of Clopidogrel ratiopharm GmbH or vice versa.
Croatian: Neki lijekovi mogu utjecati na djelovanje Klopidogrel ratiopharm GmbH i obratno.
English: Do not use Clopidogrel ratiopharm GmbH if you notice any visible sign of damage of blister or film-coated tablets.
Croatian: Klopidogrel ratiopharm GmbH se ne smije upotrijebiti ako primijetite vidljive znakove oštećenja blistera ili filmom obloženih tableta.
English: You should take Clopidogrel ratiopharm GmbH for as long as your doctor continues to prescribe it.
Croatian: Klopidogrel ratiopharm GmbH trebate uzimati sve dok Vam ga liječnik propisuje.
English: Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Croatian: Omeprazol primjenjen u dozi od 80 mg dnevno, istodobno s klopidogrelom ili s razmakom od 12 sati od primjene dvaju lijekova, smanjio je izloženost aktivnom metabolitu klopidogrela za 45% (udarna doza) i 40% (doza održavanja).
English: In a relative bioavailability study in adults, the constituted solution of clopidogrel showed a similar extent and slightly higher rate of absorption of the main circulating (inactive) metabolite compared to the authorised tablet.
Croatian: U relativnoj studiji bioraspoloživosti lijeka u odraslih, konstituirana otopina klopidogrela pokazala je sličan raspon i neznanto veću brzinu apsorpcije glavnog cirkulirajućeg (inaktivnog) metabolita, u usporedbi s tabletom.
English: If you have any further questions, ask your doctor or your pharmacist.
Croatian: - Ako imate dodatnih pitanja, obratite se liječniku ili ljekarniku.
English: Platelets (so-called thrombocytes) are very small structures, which clump together during blood clotting.
Croatian: Krvne pločice ili trombociti su vrlo mala krvna tjelešca koja se nakupljaju tijekom zgrušavanja krvi.
English: In TRITON-TIMI 38 and 3 of the cohort studies (Collet, Sibbing, Giusti) the combined group of patients with either intermediate or poor metaboliser status had a higher rate of cardiovascular events (death, myocardial infarction, and stroke) or stent thrombosis compared to extensive metabolisers.
Croatian: U studiji TRITON-TIMI 38 i 3 kohortne studije (Collet, Sibbing, Giusti), kombinirana skupina bolesnika sa statusom umjerenih ili slabih metabolizatora, imala je veću stopu kardiovaskularnih događaja (smrt, infarkt miokarda i moždani udar) ili tromboze stenta, u usporedbi s brzim metabolizatorima.
English: Children and adolescents
Croatian: • Odrasli i starije osobe
English: The safety and efficacy of clopidogrel have been evaluated in 4 double-blind studies involving over 80,000 patients: the CAPRIE study, a comparison of clopidogrel to ASA, and the CURE, CLARITY and COMMIT studies comparing clopidogrel to placebo, both medicinal products given in combination with ASA and other standard therapy.
Croatian: Klinička djelotvornost i sigurnost Sigurnost primjene i djelotvornost klopidogrela procijenjena je u 4 dvostrukoslijepe studije koje su uključivale preko 80 000 bolesnika: studija CAPRIE, u kojoj se uspoređivao klopidogrel i ASK te CURE, CLARITY i COMMIT studije, u kojima se uspoređivalo djelovanje klopidogrela prema placebu, s tim da su obje terapije davane u kombinaciji s ASK i drugom standardnom terapijom.
English: You should also tell your doctor immediately if you develop a medical condition (also known as Thrombotic Thrombocytopenic Purpura or TTP) that includes fever and bruising under the skin that may appear as red pinpoint dots, with or without unexplained extreme tiredness, confusion, yellowing of the skin or eyes (jaundice) (see section 4 ‘Possible side effects').
Croatian: • Također, odmah obavijestite svog liječnika ukoliko se pojavi medicinsko stanje (koje se naziva trombotična trombocitopenična purpura ili "TTP") sa simptomima koji uključuju vrućicu i potkožne modrice koji se mogu pojaviti kao crvene točkice, sa ili bez neobjašnjivog teškog umora, zbunjenosti i žute boje kože ili očiju (žutica) (vidjeti dio 4. "Moguće nuspojave").
English: What Clopidogrel ratiopharm GmbH is and what it is used for What you need to know before you take Clopidogrel ratiopharm GmbH How to take Clopidogrel ratiopharm GmbH Possible side effects
Croatian: Što je Klopidogrel ratiopharm GmbH i za što se koristi Što morate znati prije nego počnete uzmati Klopidogrel ratiopharm GmbH Kako uzimati Klopidogrel ratiopharm GmbH
English: Headache, stomach ulcer, vomiting, nausea, constipation, excessive gas in stomach or intestines, rashes, itching, dizziness, sensation of tingling and numbness.
Croatian: Glavobolja, ulkus želuca, povraćanje, mučnina, zatvor, povećano stvaranje plinova u želucu ili crijevima, osip, svrbež, omaglica, osjećaj trnaca i utrnulosti.
English: Jaundice; severe abdominal pain with or without back pain; fever, breathing difficulties sometimes associated with cough; generalised allergic reactions (for example, overall sensation of heat with sudden general discomfort until fainting); swelling in the mouth; blisters of the skin; skin allergy; sore mouth (stomatitis); decrease in blood pressure; confusion; hallucinations; joint pain; muscular pain; changes in taste or loss of taste of food.
Croatian: Žutica, jaka bol u trbuhu sa ili bez bolova u leđima, vrućica, teškoće pri disanju, ponekad povezane s kašljem, generalizirane alergijske reakcije (primjerice, sveukupni osjećaj vrućine s iznenadnom općom nelagodom do nesvjestice); oticanje u ustima, mjehurići na koži, kožne alergijske reakcije, upala u usnoj šupljini (stomatitis), pad krvnoga tlaka, zbunjenost, halucinacije, bol u zglobovima, bol u mišićima, poremećaj okusa ili gubitak osjeta okusa hrane.
English: Then, the recommended dose is one 75 mg tablet of Clopidogrel ratiopharm GmbH per day to be taken orally with or without food, and at the same time each day.
Croatian: Nakon toga, preporučena doza Klopidogrel ratiopharm GmbH je jedna tableta od 75 mg dnevno koja se uzima kroz usta s obrokom ili bez obroka, u isto vrijeme svaki dan.
English: Clopidogrel ratiopharm GmbH 75 mg film-coated tablets are white to off-white, marbled, round and biconvex.
Croatian: Klopidogrel ratiopharm GmbH 75 mg filmom obložene tablete su bijele do gotovo bijele, mramorne, okrugle i bikonveksne tablete.
English: In addition, IPA was 32% (24 hours) and 61% (Day 5), which were greater than in the poor metabolisers receiving the 300 mg/75 mg regimen, and were similar to the other CYP2C19 metaboliser groups receiving the 300 mg/75 mg regimen.
Croatian: IPA iznosila je 32% (24 sata) i 61% (dan 5), što je više nego u slabih metabolizatora koji su primali režim doziranja od 300 mg/75 mg i slično je ostalim skupinama CYP2C19 metabolizatora koje su primale doze od 300 mg/75 mg.
English: Sími: +358 20 180 5900
Croatian: Finnland Sími: +358 20 180 5900
English: Clopidogrel ratiopharm GmbH is unlikely to affect your ability to drive or to use machines.
Croatian: Klopidogrel ratiopharm GmbH ne bi trebao utjecati na Vašu sposobnost upravljanja vozilima ili strojevima.
English: Musculo-skeletal bleeding (haemarthrosis), arthritis, arthralgia, myalgia
Croatian: Mišićnokoštano krvarenje (hemartroza), artritis, artralgija, mijalgija
English: Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, carbamazepine, and efavirenz.
Croatian: Lijekovi su jaki ili umjereni inhibitori CYP2C19 uključuju, primjerice, omeprazol i esomeprazol, fluvoksamin, fluoksetin, moklobemid, vorikonazol, flukonazol, tiklopidin, karbamazepin i efavirenz.
English: EU/1/09/541/001 - Cartons of 14 film-coated tablets in Alu/Alu blisters EU/1/09/541/002 - Cartons of 28 film-coated tablets in Alu/Alu blisters EU/1/09/541/003 - Cartons of 30 film-coated tablets in Alu/Alu blisters EU/1/09/541/004 - Cartons of 50 film-coated tablets in Alu/Alu blisters EU/1/09/541/005 - Cartons of 84 film-coated tablets in Alu/Alu blisters EU/1/09/541/006 - Cartons of 90 film-coated tablets in Alu/Alu blisters EU/1/09/541/007 - Cartons of 100 film-coated tablets in Alu/Alu blisters EU/1/09/541/008 - Cartons of 7 film-coated tablets in Alu/Alu blisters
Croatian: EU/1/09/541/001 - Kutije sa 14 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/002 - Kutije sa 28 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/003 - Kutije sa 30 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/004 - Kutije sa 50 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/005 - Kutije sa 84 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/006 - Kutije sa 90 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/007 - Kutije sa 100 filmom obloženih tableta u Al/Al blisterima EU/1/09/541/008 - Kutije sa 7 filmom obloženih tableta u Al/Al blisterima
English: Fifteen percent (15.0%) of patients in the clopidogrel group and 21.7% in the placebo group reached the primary endpoint, representing an absolute reduction of 6.7% and a 36% odds reduction in favour of clopidogrel (95% CI: 24, 47%; p< 0.001), mainly related to a reduction in occluded infarct-related arteries.
Croatian: Petnaest posto (15,0%) bolesnika u skupini s klopidogrelom i 21,7% u skupini s placebom dostigli su primarni ishod, što predstavlja apsolutno smanjenje od 6,7% i smanjenje izgleda (engl. odds reduction) od 36% u korist klopidogrela (95% CI: 24, 47%; p<0,001), većinom povezano sa smanjenjem okluzije arterija povezanih s infarktom.
English: Consistent with the above results, in a meta-analysis including 6 studies of 335 clopidogrel-treated subjects at steady state, it was shown that active metabolite exposure was decreased by 28% for intermediate metabolisers, and 72% for poor metabolisers while platelet aggregation inhibition (5 μM ADP) was decreased with differences in IPA of 5.9% and 21.4%, respectively, when compared to extensive metabolisers.
Croatian: U skladu s gore navedenim rezultatima, u metaanalizi koja je uključivala 6 studija s 335 osoba liječenih klopidogrelom u stanju dinamičke ravnoteže, pokazano je da je izloženost aktivnom metabolitu smanjena za 28% za umjerene metabolizatore te 72% za slabe metabolizatore, dok je inhibicija agregacije trombocita (5 μM ADP) smanjena s razlikama za vrijednsoti IPA-e od 5,9%, odnosno 21,4%, u usporedbi s brzim metabolizatorima.
English: swelling in the mouth or skin disorders such as rashes and itching, blisters of the skin.
Croatian: - oticanje u ustima ili kožni poremećaji kao što su osip i svrbež te mjehurići na koži.
English: -Very rare side effects (may affect up to 1 in 10,000 people):
Croatian: -Vrlo rijetke nuspojave (mogu se javiti u manje od 1 na 10 000 osoba):
English: Clopidogrel ratiopharm GmbH contains the active ingredient Clopidogrel which belongs to a group of medicines called antiplatelet medicinal products.
Croatian: Klopidogrel ratiopharm GmbH sadrži djelatnu tvar klopidrogel i pripada skupini lijekova koji se nazivaju antitrombocitni lijekovi.
English: Acute liver failure, hepatitis, abnormal liver function test
Croatian: Akutno zatajenje jetre, hepatitis, abnormalni nalazi jetrene funkcije