FrancophonIA/ELRC3.0 huggingface dataset:
English: If you suffer from Parkinson's disease you should not stop treatment with Oprymea abruptly.
Croatian: Ako patite od Parkinsonove bolesti, ne smijete naglo prekidati liječenje lijekom Oprymea.
English: Do not chew, divide or crush the prolonged-release tablets.
Croatian: Ne žvačite, lomite ili drobite tablete s produljenim oslobađanjem.
English: Intake of a high fat meal induced an increase in peak concentration (Cmax) of about 24% after a single dose administration and about 20% after multiple dose administrations and a delay of about 2 hours in time to reach peak concentration in healthy volunteers.
Croatian: Unos obroka s visokim udjelom masnoća potaknuo je porast vršnih koncentracija (Cmax) od oko 24% nakon jednokratne primjene i oko 20% nakon višestruke primjene doze te odgodu od oko 2 sata u postizanju vršne koncentracije u zdravih dobrovoljaca.
English: Reports in the literature indicate that treatment of Restless Legs Syndrome with dopaminergic medicinal products can result in augmentation.
Croatian: Podaci u literaturi ukazuju da liječenje sindroma nemirnih nogu dopaminergičkim lijekovima može rezultirati augmentacijom.
English: Due to the selection of animal species and the limited parameters investigated, the adverse effects of pramipexole on pregnancy and male fertility have not been fully elucidated.
Croatian: Zbog selekcije životinjskih vrsta i ograničenosti istraživanih parametara, nema konačnog zaključka o nuspojavama pramipeksola na trudnoću i mušku plodnost.
English: - Uncontrollable excessive shopping or spending.
Croatian: pretjerano kupovanje ili trošenje koje se ne može kontrolirati*
English: Tell your doctor if you or your family/carer notices that you are developing urges or cravings to behave in ways that are unusual for you and you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others.
Croatian: Obavijestite liječnika ako Vi ili Vaša obitelj/njegovatelj(ica) primijetite da razvijate snažnu potrebu ili žudnju za ponašanjem na za Vas neobičan način te se ne možete oduprijeti nagonu, porivu ili iskušenju da vršite određene aktivnosti koje bi mogle naškoditi Vama ili drugima.
English: However, the potential influence of hepatic insufficiency on Oprymea pharmacokinetics has not been investigated.
Croatian: Međutim, potrebno je znati da potencijalni utjecaj insuficijencije jetre na farmakokinetiku lijeka Oprymea nije istraživan.
English: The tablets should be swallowed whole with water, and must not be chewed, divided or crushed.
Croatian: Tablete se gutaju cijele, s vodom, te se ne smiju žvakati, dijeliti ili drobiti.
English: Two trials were conducted in patients with early Parkinson's disease and one trial was conducted in patients with advanced Parkinson's disease.
Croatian: Dva ispitivanja su provedena na bolesnicima s ranim stadijem Parkinsonove bolesti, a jedno ispitivanje je provedeno na bolesnicima s uznapredovalom Parkinsonovom bolešću.
English: Adverse events occurring in at least 5% of patients in the pramipexole group and more common in the pramipexole-treated patients than in patients on placebo were: headache (27.9%, placebo 25.0%), somnolence (7.0%, placebo 5.0%), nausea (18.6%, placebo 10.0%), vomiting (11.6%, placebo 0.0%), upper abdominal pain (7.0%, placebo 5.0%), orthostatic hypotension (9.3%, placebo 5.0%), myalgia (9.3%, placebo 5.0%), sleep disorder (7.0%, placebo 0.0%), dyspnoea (7.0%, placebo 0.0%) and upper respiratory tract infection (7.0%, placebo 5.0%).
Croatian: Nuspojave, koje su imali najmanje 5% bolesnika u skupini na pramipeksolu i češće bolesnici liječeni pramipeksolom u odnosu na bolesnike na placebu, bile su: glavobolja (27,9%, placebo 25%), somnolencija (7,0%, placebo 5,0%), mučnina (18,6%, placebo 10,0%), povraćanje (11,6%, placebo 0,0%), bolovi u predjelu gornjeg abdomena (7,0%, placebo 5,0%), ortostatska hipotenzija (9,3%, placebo 5,0%), mijalgija (9,3%, placebo 5,0%), poremećaj spavanja (7,0%, placebo 0,0%), dispneja (7,0%, placebo 0,0%) i infekcije gornjih dišnih puteva (7,0%, placebo 5,0%).
English: If renal function declines during maintenance therapy the Oprymea daily dose should be reduced by the same percentage as the decline in creatinine clearance, i.e. if creatinine clearance declines by 30%, then the Oprymea daily dose should be reduced by 30%.
Croatian: Ukoliko dođe do pogoršanja funkcije bubrega za vrijeme terapije održavanja, dnevnu dozu lijeka Oprymea je potrebno sniziti u istom postotku za koji se smanjio klirens kreatinina, tj. ako se klirens smanjio za 30%, tada je potrebno sniziti ukupnu dnevnu dozu lijeka Oprymea za 30%.
English: In humans, the protein binding of pramipexole is very low (< 20%) and the volume of distribution is large (400 l).
Croatian: U ljudi, vezanje pramipeksola na proteine plazme je vrlo nisko (< 20%), a volumen distribucije je vrlo velik (400 l).
English: If you have serious kidney problems, your doctor may need to switch you to a different pramipexole medicine.
Croatian: Ako imate teške probleme s bubrezima, liječnik će Vas možda trebati prebaciti na drugi lijek s pramipeksolom.
English: BOX for blisters
Croatian: KUTIJA za blistere
English: You should have regular eye examinations during treatment with Oprymea - Severe heart or blood vessels disease.
Croatian: Potreban je redovit pregled očiju tijekom liječenja lijekom Oprymea Teška bolest srca ili krvnih žila.
English: In half of the 16 patients who did not meet the criterion for maintained efficacy on UPDRS Part II+III score, the change from baseline was considered not clinically relevant.
Croatian: U polovine od 16 bolesnika koji nisu udovoljili kriteriju za održavanje učinka prema rezultatu na UPDRS ljestvici, dijelovima II+III, promjena u odnosu na početnu vrijednost ne smatra se klinički značajnom.
English: OUTER BOX (treatment initiation pack containing 3 boxes of 7 prolonged-release tablets)
Croatian: VANJSKA KUTIJA (pakiranje za početno liječenje sadrži 3 kutije sa po 7 tableta s produljenim oslobađanjem)
English: If you forget to take a dose of Oprymea, but remember within 12 hours of your usual time, take your tablet straightaway and then take your next tablet at the usual time.
Croatian: Ako ste zaboravili uzeti dozu lijeka Oprymea te se sjetite u roku 12 sati od uobičajenog vremena doziranja, uzmite tabletu odmah, a zatim uzmite sljedeću tabletu u uobičajeno vrijeme.
English: If this happens, your doctor may want to change your medication.
Croatian: U tom će vam slučaju Vaš liječnik možda promijeniti lijekove.
English: Patients should be regularly monitored for the development of impulse control disorders.
Croatian: Bolesnike je potrebno redovito pratiti radi mogućeg razvoja poremećaja kontrole nagona.
English: Do not stop taking Oprymea without first talking to your doctor.
Croatian: Ne prekidajte uzimanje lijeka Oprymea bez prethodnog razgovora s liječnikom.
English: Common (≥1/100 to
Croatian: Često (≥1/100 i
English: The usual maintenance dose is 1.05 mg per day.
Croatian: Uobičajena doza održavanja je 1,05 mg dnevno.
English: The tablets should be taken orally, swallowed with water, and can be taken either with or without food.
Croatian: Način primjene Tablete se uzimaju peroralno, gutaju se s vodom, te se mogu uzimati sa ili bez hrane.
English: Patients already taking Oprymea tablets may be switched to Oprymea prolonged-release tablets overnight, at the same daily dose.
Croatian: Bolesnici koji već uzimaju Oprymea tablete mogu se prebaciti na Oprymea tablete s produljenim oslobađanjem „preko noći“, u jednakoj dnevnoj dozi.
English: However, in Phase III trials in Parkinson's disease patients no clinically meaningful influence of body weight on the therapeutic effect and tolerability of pramipexole prolonged-release tablets was detected.
Croatian: Međutim, u fazi III kliničkog ispitivanja na bolesnicima s Parkinsonovom bolešću nije pronađen klinički značajan utjecaj tjelesne težine na terapijski učinak i podnošljivost pramipeksol tableta s produljenim oslobađanjem.
English: In a clinical trial with healthy volunteers, where pramipexole prolonged-release tablets were titrated faster (every 3 days) than recommended up to 3.15 mg pramipexole base (4.5 mg of salt) per day, an increase in blood pressure and heart rate was observed.
Croatian: U kliničkom ispitivanju na zdravim dobrovoljcima, gdje su pramipeksol tablete s produljenim oslobađanjem brže titrirane (svaka 3 dana) nego što je preporučeno do 3,15 mg baze pramipeksola (4,5 mg soli) dnevno, primijećeni su porast krvnog tlaka i srčane frekvencije.
English: In a pharmacoepidemiological study pramipexole use was associated with an increased risk of cardiac failure compared with non-use of pramipexole (observed risk ratio 1.86; 95% CI, 1.21
Croatian: U farmakoepidemiološkoj studiji, primjena pramipeksola bila je povezana s povećanim rizikom od zatajenja srca u usporedbi s neprimjenom pramipeksola (primijećeni omjer rizika 1,86; 95% CI; 1,21-2,85).
English: In the Phase III studies that established safety and efficacy of pramipexole prolonged-release tablets, patients were instructed to take study medication without regard to food intake.
Croatian: U ispitivanjima faze III, koja su utvrđivala sigurnost i učinkovitost pramipeksol tableta s produljenim oslobađanjem, bolesnici su bili upućeni na uzimanje lijeka iz ispitivanja, bez obzira na unos hrane.
English: Tell your doctor if you experience symptoms such as depression, apathy, anxiety, fatigue, sweating or pain after stopping or reducing your Oprymea treatment.
Croatian: Obavijestite svog liječnika ako osjetite simptome poput depresije, apatije, tjeskobe, umora, znojenja ili boli nakon prestanka liječenja ili sniženja doze lijeka Oprymea.
English: Clinical efficacy and safety in Tourette Disorder
Croatian: Klinička djelotvornost i sigurnost u Touretteovom sindromu
English: In early and advanced Parkinson's disease, efficacy of pramipexole in controlled clinical trials was maintained for approximately six months.
Croatian: U ranoj i uznapredovaloj Parkinsonovoj bolesti, djelotvornost pramipeksola u kontroliranim kliničkim ispitivanjima održavana je tijekom 6 mjeseci.
English: In a controlled double blind clinical trial of 2 year duration, initial treatment with pramipexole significantly delayed the onset of motor complications, and reduced their occurrence compared to initial treatment with levodopa.
Croatian: U kontroliranom, dvostruko-slijepom kliničkom ispitivanju u trajanju od 2 godine, početno liječenje pramipeksolom je značajno odgodilo pojavu motoričkih komplikacija te smanjilo njihovu pojavnost u usporedbi s početnim liječenjem primjenom levodope.
English: These are called impulse control disorders and can include behaviours such as addictive gambling, excessive eating or spending, an abnormally high sex drive or preoccupation with an increase in sexual thoughts or feelings.
Croatian: Oni se nazivaju poremećajima kontrole nagona te mogu uključivati ponašanja kao što je ovisničko kockanje, prekomjerno jedenje ili trošenje, abnormalno velik spolni nagon ili učestalo razmišljanje s povećanom količinom seksualnih maštarija ili osjećaja.
English: In a cross-sectional, retrospective screening and case-control study including 3,090 Parkinson's disease patients, 13.6% of all patients receiving dopaminergic or non-dopaminergic treatment had symptoms of an impulse control disorder during the past six months.
Croatian: U presječnom, retrospektivnom ispitivanju „screening“-om i analizom slučaja, koje je uključivalo 3090 bolesnika s Parkinsonovom bolešću, 13,6% svih bolesnika koji su primali dopaminergičko ili nedopaminergičko liječenje imalo je simptome poremećaja kontrole nagona tijekom proteklih šest mjeseci.
English: The daily dose can be administered in two divided doses if creatinine clearance is between 20 and 50 ml/min, and as a single daily dose if creatinine clearance is less than 20 ml/min.
Croatian: Ukupna dnevna doza može se primjenjivati u dvije odvojene doze ako je klirens kreatinina u rasponu od 20 i 50 ml/min, te u jednoj dnevnoj dozi ako je klirens kreatinina manji od 20 ml/min.
English: High brain tissue concentrations were observed in the rat (approx. 8-fold compared to plasma).
Croatian: Visoke koncentracije u moždanom tkivu primijećene su u štakora (oko 8 puta u usporedbi s plazmatskim).
English: Possible independent risk factors for impulse control disorders included dopaminergic treatments and higher doses of dopaminergic treatment, younger age (≤ 65 years), not being married and self-reported family history of gambling behaviours.
Croatian: Mogući neovisni rizični faktori za poremećaje kontrole nagona uključivali su dopaminergička liječenja i više doze dopaminergičkog liječenja, mlađu dob (≤ 65 godina), status samca i samoprijavljenu obiteljsku anamnezu pojave kockanja.
English: You should be cautious while drinking alcohol during treatment with Oprymea.
Croatian: Potreban je oprez prilikom konzumacije alkohola tijekom liječenja lijekom Oprymea.
English: You should avoid taking Oprymea together with antipsychotic medicines.
Croatian: Potrebno je izbjegavati istodobnu primjenu lijeka Oprymea i antipsihotičnih lijekova.
English: Other significant adverse events leading to discontinuation of study medication for patients receiving pramipexole were confusional state, speech disorder and aggravated condition (see section 4.2).
Croatian: Druge značajne nuspojave za bolesnike na pramipeksolu koje su dovele do prekida uzimanja ispitivanog lijeka bile su konfuzno stanje, poremećaj govora i pogoršanje stanja (vidjeti dio 4.2).
English: Pramipexole is a dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity.
Croatian: Pramipeksol je agonist dopamina koji se s visokom selektivnošću i specifičnošću veže za D2 podskupinu dopaminskih receptora od kojih poseban afinitet pokazuje za D3 receptore i ima potpuno intrinzičko djelovanje.
English: The following dose schedule is suggested for initiation of therapy:
Croatian: Preporučuje se sljedeća shema doziranja u početku terapije:
English: Take Oprymea prolonged-release tablets only once a day and each day at about the same time.
Croatian: Uzimajte Oprymea tablete s produljenim oslobađanjem jedanput dnevno i to svaki dan otprilike u isto vrijeme.
English: A sudden stop could cause you to develop a medical condition called neuroleptic malignant syndrome which may represent a major health risk.
Croatian: Iznenadan prekid može dovesti do razvoja medicinskog stanja koje se naziva maligni neuroleptični sindrom, koji može predstavljati velik rizik za zdravlje.
English: The efficacy of pramipexole (0.0625-0.5 mg/day) with paediatric patients aged 6-17 years with Tourette Disorder was evaluated in a 6-week, double-blind, randomised, placebo-controlled flexible dose study.
Croatian: Djelotvornost pramipeksola (0,0625-0,5 mg/dan) ocjenjivana je na pedijatrijskim bolesnicima u dobi od 617 godina s Touretteovim sindromom tijekom 6 tjedana u dvostruko-slijepom, randomiziranom, placebom kontroliranom, fleksibilnom ispitivanju doza.
English: If you stop taking Oprymea
Croatian: Ako prestanete uzimati lijek Oprymea
English: Approximately 90% of C-labelled dose is excreted through the kidneys while less than 2% is found in the faeces.
Croatian: C izlučuje se putem bubrega, dok se manje od 2% nalazi u fecesu.
English: Endocrine inappropriate disorders antidiuretic hormone secretion
Croatian: Endokrini poremećaji neodgovarajuće izlučivanje antidiuretskog hormona
English: Libido disorders Pramipexole may uncommonly be associated with libido disorders (increased or decreased).
Croatian: Poremećaji libida Pramipeksol može biti povezan s poremećajima libida (pojačan ili smanjen).
English: (eating more food than normal and more than is needed to satisfy your hunger)* - Delirium (decreased awareness, confusion, loss of reality)
Croatian: (jedenje veće količine hrane nego što je normalno i više nego je potrebno za utaženje gladi)* delirij (poremećaj svijesti, smetenost, gubitak osjećaja za stvarnost)
English: Blister (OPA/Alu/desiccant/PE-Alu foil): 21 prolonged-release tablets (3 blisters of 7 tablets): - 7 prolonged-release tablets of 0.26 mg
Croatian: Blister (OPA/Al/desikant/PE-Al folija): 21 tableta s produljenim oslobađanjem (3 blistera sa po 7 tableta): 7 tableta s produljenim oslobađanjem od 0,26 mg
English: Co-administration of antipsychotic medicinal products with pramipexole should be avoided (see section 4.4), e.g. if antagonistic effects can be expected.
Croatian: Treba izbjegavati istodobnu primjenu antipsihotičnih lijekova i pramipeksola (vidjeti dio 4.4), npr. ako se očekuju antagonistički učinci.
English: After switching to Oprymea prolonged-release tablets, the dose may be adjusted depending on the patient's therapeutic response (see section 5.1).
Croatian: Nakon prijelaza na Oprymea tablete s produljenim oslobađanjem, doza se može podesiti prema terapijskom odgovoru bolesnika (vidjeti dio 5.1).
English: If affected, do not drive or use machines.
Croatian: Ukoliko se to dogodi, nemojte upravljati vozilima ili strojevima.
English: In animal studies, pramipexole affected oestrous cycles and reduced female fertility as expected for a dopamine agonist.
Croatian: U ispitivanjima na životinjama, pramipeksol je utjecao na spolne cikluse i smanjenu plodnost ženki, kao što se očekivalo za dopaminske agoniste.
English: The maximum plasma concentrations occur at about 6 hours after administration of pramipexole prolonged-release tablets once daily.
Croatian: Maksimalne koncentracije u plazmi se javljaju oko 6 sati nakon primjene pramipeksol tableta s produljenim oslobađanjem jedanput dnevno.
English: Oprymea can cause hallucinations (seeing, hearing or feeling things that are not there).
Croatian: Oprymea može izazvati halucinacije (možete vidjeti, čuti ili osjećati stvari koje nisu prisutne).
English: If you are taking levodopa, the dose of levodopa is recommended to be reduced when you start treatment with Oprymea.
Croatian: Ako uzimate levodopu, preporučuje se snižavanje doze levodope pri započinjanju liječenja lijekom Oprymea.
English: The safety and efficacy of pramipexole prolonged-release tablets in the treatment of Parkinson's disease was evaluated in a multinational drug development program consisting of three randomised, controlled trials.
Croatian: Sigurnost i djelotvornost pramipeksol tableta s produljenim oslobađanjem u liječenju Parkinsonove bolesti ocjenjivane su u multinacionalnom razvojnom programu lijeka koji se sastojao od tri randomizirana kontrolirana ispitivanja.
English: Oprymea is indicated in adults for symptomatic treatment of moderate to severe idiopathic Restless Legs Syndrome in doses up to 0.54 mg of base (0.75 mg of salt) (see section 4.2).
Croatian: Oprymea je indicirana za simptomatsko liječenje umjerenog do teškog idiopatskog sindroma nemirnih nogu u odraslih pri dozama do 0,54 mg baze (0,75 mg soli) (vidjeti dio 4.2).
English: 3-week treatment initiation pack
Croatian: Pakiranje za 3-tjedno početno liječenje
English: Oprymea contains the active substance pramipexole and belongs to a group of medicines known as dopamine agonists which stimulate dopamine receptors in the brain.
Croatian: Oprymea sadrži djelatnu tvar pramipeksol i pripada skupini lijekova poznatih kao agonisti dopamina koji stimuliraju dopaminergičke receptore u mozgu.
English: When the intake of a dose is missed, Oprymea prolonged-release tablets should be taken within 12 hours after the regularly scheduled time.
Croatian: Kada se propusti doziranje, Oprymea tablete s produljenim oslobađanjem se uzimaju u roku 12 sati nakon redovnog vremena doziranja.
English: The absolute bioavailability is greater than 90%.
Croatian: Apsolutna bioraspoloživost je veća od
English: If a further dose increase is necessary, your doctor may adjust it in steps of 0.26 mg pramipexole.
Croatian: Ako je potrebno daljnje povisivanje doze, liječnik ju može prilagoditi postupno s po 0,26 mg pramipeksola.
English: The safety and efficacy of Oprymea in children below 18 years has not been established.
Croatian: Sigurnost i djelotvornost lijeka Oprymea u djece u dobi do 18 godina nisu ustanovljene.
English: Oprymea should not be used in children or adolescents with Tourette Disorder because of a negative benefit-risk balance for this disorder (see section 5.1).
Croatian: Oprymea se ne smije primjenjivati u djece i adolescenata s Touretteovim sindromom zbog negativnog omjera koristi i rizika za ovaj poremećaj (vidjeti dio 5.1).
English: Biotransformation Pramipexole is metabolised in man only to a small extent.
Croatian: Biotransformacija Pramipeksol se u ljudi metabolizira u maloj količini.
English: If you forget to take Oprymea
Croatian: Ako ste zaboravili uzeti lijek Oprymea
English: You may experience the following side effects:
Croatian: Možete imati sljedeće nuspojave:
English: Rare to
Croatian: Vrlo rijetko:
English: If you have kidney disease, your doctor may advise you to take the usual starting dose of 0.26 mg prolonged-release tablets only every other day for the first week.
Croatian: Ako imate oštećenje bubrega, liječnik Vam može preporučiti uobičajenu početnu dozu od 0,26 mg tableta s produljenim oslobađanjem tek svaki drugi dan tijekom prvog tjedna.
English: Management of the overdose may require general supportive measures, along with gastric lavage, intravenous fluids, administration of activated charcoal and electrocardiogram monitoring.
Croatian: Zbrinjavanje predoziranja može zahtijevati opće mjere, zajedno s lavažom želuca, primjenom intravenskih tekućina, aktivnog ugljena i praćenjem putem elektrokardiograma.
English: The mean change from baseline in the Restless Legs Syndrome Rating Scale (IRLS) and the Clinical Global Impression-Improvement (CGI-I) were the primary efficacy outcome measures.
Croatian: Prosječne promjene od početnih vrijednosti na Ocjenjivačkoj ljestvici sindroma nemirnih nogu (IRLS) i Ljestvici općeg kliničkog dojma - Poboljšanje (CGI-I, Clinical Global Impression-Improvement) bile su primarne ishodne mjere za procjenu djelotvornosti.
English: CGI-I responder rates (much improved, very much improved) were 50.3% (80/159) and 68.5% (111/162) for placebo and pramipexole, respectively (p = 0.001), corresponding to a number needed to treat (NNT) of 6 patients (95%CI: 3.5, 13.4).
Croatian: Stope odgovora prema CGI-I-u (znatno poboljšanje, veliko poboljšanje) bile su 50,3 % (80/159) za placebo i 68,5% (111/162) za pramipeksol (p=0,001), što odgovara broju potrebnom za liječenje (NNT) 6 bolesnika (95%CI: 3,5; 13,4).
English: Blister pack (Alu/Alu foil): 20, 30, 60, 90 or 100 tablets, in a box.
Croatian: Blister pakiranje (Al/Al folija): 20, 30, 60, 90 ili 100 tableta, u kutiji.
English: The European Medicines Agency has waived the obligation to submit the results of studies with pramipexole in all subsets of the paediatric population in Parkinson's Disease (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja pramipeksola u svim podskupinama pedijatrijske populacije s Parkinsonovom bolešću (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: The European Medicines Agency has deferred the obligation to submit the results of studies with pramipexole in one or more subsets of the paediatric population in Restless Legs Syndrome (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja s pramipeksolom u jednoj ili više podskupina pedijatrijske populacije sa sindromom nemirnih nogu (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: Oprymea prolonged-release tablet is a specially designed tablet from which the active ingredient is gradually released, once the tablet has been ingested.
Croatian: Oprymea tablete s produljenim oslobađanjem posebno su oblikovane tablete iz kojih se djelatna tvar postupno oslobađa nakon što se tableta proguta.
English: 63 % of patients on pramipexole and 52% of patients on placebo reported at least one adverse drug reaction.
Croatian: 63% bolesnika na pramipeksolu i 52% bolesnika na placebu prijavilo je najmanje jednu nuspojavu.