FrancophonIA/ELRC3.0 huggingface dataset:
English: Effects on viral load were consistently more pronounced in patients treated with indinavir in combination with nucleoside analogues, but the proportion of patients with serum viral RNA below the limit of quantification (500 copies/mL) varied between studies, at week 24 from 40 % to more than 80 %.
Croatian: Učinci na virusno opterećenje bili su dosljedno izraženiji u bolesnika liječenih indinavirom u kombinaciji sa nukleozidnim analozima, ali se udio bolesnika u kojih je virusna RNK u serumu bila ispod razine mjerljivosti (500 kopija/ml) razlikovao od ispitivanja do ispitivanja pa se u 24. tjednu kretao u rasponu od 40% do više od 80%.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Croatian: Bolesnici s kroničnim hepatitisom B ili C koji se liječe kombiniranom antiretrovirusnom terapijom izloženi su povećanom riziku za razvoj teških jetrenih nuspojava s mogućim smrtnim ishodom.
English: Concurrent use of indinavir with rifampicin or herbal preparations containing St John's wort (Hypericum perforatum) is contraindicated.
Croatian: Istodobna primjena indinavira s rifampicinom ili biljnim pripravcima koji sadrže gospinu travu (Hypericum perforatum) je kontraindicirana.
English: *)historical controls
Croatian: *) kontrole iz prethodnih ispitivanja
English: Over the 200-1,000-mg dose range administered in both volunteers and HIV infected patients, there was a slightly greater than dose-proportional increase in urinary recovery of indinavir.
Croatian: U rasponu doza od 200-1000 mg primijenjenih u dobrovoljaca i bolesnika zaraženih HIV-om primijećen je porast koncentracije indinavira u mokraći neznatno veći od proporcionalnoga dozi.
English: Indinavir AUC:  31 % Indinavir Cmin:  40 %
Croatian: AUC indinavira:  31% Cmin indinavira:  40%
English: rash, dry skin pruritus rash including erythema multiforme and Stevens Johnson syndrome, hypersensitivity vasculitis, alopecia, hyperpigmentation, urticaria; ingrown toenails and/or paronychia.
Croatian: osip, suha koža pruritus osip, uključujući multiformni eritem i StevensJohnsonov sindrom, hipersenzitivni vaskulitis, alopecija, hiperpigmentacija, urtikarija, urastanje noktiju na nožnim prstima i/ili paronihija
English: Concomitant use of indinavir with lovastatin or simvastatin is not recommended due to an increased risk of myopathy including rhabdomyolysis.
Croatian: Ne preporučuje se istodobna primjena indinavira s lovastatinom ili simvastatinom zbog povećanog rizika od miopatije, uključujući rabdomiolizu.
English: Co-administration of CRIXIVAN with sildenafil, tadalafil and vardenafil (PDE5 inhibitors) are expected to substantially increase the plasma concentrations of these compounds and may result in an increase in PDE5 inhibitor-associated adverse events, including hypotension, visual changes, and priapism (see section 4.5).
Croatian: Očekuje se da bi istodobna primjena lijeka CRIXIVAN sa sildenafilom, tadalafilom i vardenafilom (inhibitorima PDE5) mogla značajno povisiti koncentracije navedenih spojeva u plazmi i dovesti do povećanja broja nuspojava povezanih s inhibitorima PDE5, uključujući hipotenziju, promjene vida i prijapizam (vidjeti dio 4.5).
English: Marketing Authorisation Holder: Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, The Netherlands
Croatian: Nositelj odobrenja: Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, Nizozemska
English: Indinavir did not alter the type, frequency, or severity of known major adverse effects associated with the use of zidovudine, didanosine, or lamivudine.
Croatian: Indinavir nije utjecao na vrstu, učestalost ni težinu poznatih glavnih nuspojava povezanih s primjenom zivudina, didanozina ili lamivudina.
English: Following initiation of indinavir/ritonavir 800/100 BID or lopinavir/ritonavir 400/100 BID, dose reduction of cyclosporine A to 5-20 % of prior dose was needed to maintain cyclosporine A levels within therapeutic range in one study.
Croatian: Nakon započinjanja liječenja indinavirom/ritonavirom pri dozi od 800/100 BID ili lopinavirom/ritonavirom pri dozi od 400/100 BID u jednom je ispitivanju bilo potrebno smanjiti dozu ciklosporina
English: CsA levels require progressive dose adjustment using therapeutic medicinal product monitoring.
Croatian: A iziskuju progresivno prilagođavanje doze uz praćenje terapijskih učinaka lijeka.
English: If a patient is already taking St. John's wort, stop St. John's wort, check viral levels and if possible indinavir levels.
Croatian: Ako bolesnik već uzima gospinu travu, mora je prestati uzimati te treba provjeriti razinu virusa i, po mogućnosti, razinu indinavira.
English: The use of indinavir/ritonavir with quinidine is contraindicated.
Croatian: Primjena indinavira/ritonavira s kinidinom je kontraindicirana.
English: Combinations of atazanavir with or without ritonavir and Crixivan have not been studied and co-administration of these medicinal products is not recommended due to risk of worsening of these adverse reactions.
Croatian: Kombinacije atazanavira, s ritonavirom ili bez njega, i lijeka CRIXIVAN nisu ispitivane pa se istodobna primjena navedenih lijekova ne preporučuje zbog rizika od pogoršanja opisanih nuspojava.
English: There is no significant effect of unboosted indinavir on methadone AUC (see Table 1 above).
Croatian: Indinavir bez pojačanja ritonavirom nema značajnog utjecaja na AUC metadona (vidjeti Tablicu 1 gore).
English: If any of the above apply to you (or you are not sure), talk to your doctor, pharmacist or nurse before taking CRIXIVAN.
Croatian: Ako se nešto od navedenog odnosi na Vas (ili niste sigurni), obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete CRIXIVAN.
English: Amprenavir 1,200 mg BID AUC ↑90 % with 800 mg TID indinavir alone (see Table 1).
Croatian: Amprenavir 1200 mg BID AUC ↑90% kad se primjenjuje samo s indinavirom u dozi od 800 mg TID (vidjeti Tablicu 1).
English: Combination of atazanavir with or without ritonavir and Crixivan are not recommended due to increased risk of hyperbilirubinemia (see section 4.4).
Croatian: Kombinacija atazanavira, s ritonavirom ili bez njega, i lijeka CRIXIVAN se ne preporučuje zbog povećanog rizika od hiperbilirubinemije (vidjeti dio 4.4).
English: Interactions between indinavir and other medicinal products are listed in the tables below (increase is indicated as “↑”, decrease as “↓”, no change (≤ +/- 20 %) as “↔”, single dose as “SD”, once daily as “QD”, twice daily as “BID”, three times daily as “TID”, and four times daily as "QID").
Croatian: Interakcije između indinavira i drugih lijekova navedene su u tablicama koje slijede (porast je označen kao "↑", smanjenje kao "↓", nepromijenjeno stanje (≤ +/- 20%) kao "↔", jedna doza kao "SD", doziranje jedanput na dan kao "QD", doziranje dvaput na dan kao "BID", doziranje triput na dan kao "TID" i doziranje četiri puta na dan kao "QID").
English: In Rhesus monkeys, administration of indinavir to neonates caused a mild exacerbation of the transient physiologic hyperbilirubinaemia seen in this species after birth.
Croatian: U rezus majmuna je primjena indinavira u netom okoćene mladunčadi izazvala blagu egzacerbaciju prolazne fiziološke hiperbilirubinemije koja se u te vrste javlja nakon okota.
English: Stavudine AUC: ↑ 21 % Stavudine Cmin: not evaluated
Croatian: AUC stavudina: ↑ 21% Cmin stavudina: nije ocijenjen
English: ANTIARRTHYMICS Digoxin 0.4 mg SD Ritonavir 200 mg BID
Croatian: ANTIARITMICI Digoksin 0,4 mg SD Ritonavir 200 mg BID
English: • liver problems such as inflammation or liver failure
Croatian: • tegobe s jetrom, poput upale ili zatajenja jetre
English: No studies on the effects on the ability to drive and use machines have been performed.
Croatian: Nisu provedena ispitivanja o djelovanju lijeka na sposobnost upravljanja vozilima i rada na strojevima.
English: The mean indinavir plasma AUC0-8hr at week 30-32 of gestation (n = 11) was 9,231 nMhr, which is 74 % (95 % CI: 50 %, 86 %) lower than that observed 6 weeks postpartum.
Croatian: Srednji AUC0-8h indinavira u plazmi u 30.-32. tjednu trudnoće (n = 11) iznosio je 9231 nMh, što je 74% (95% CI: 50%, 86%) niže nego 6 tjedana nakon poroda.
English: How to take CRIXIVAN
Croatian: Kako uzimati CRIXIVAN
English: Delavirdine 400 mg TID Indinavir 400 mg TID
Croatian: Delavirdin 400 mg TID Indinavir 400 mg TID
English: Treatment with indinavir alone or in combination with other antiretroviral agents (i.e., nucleoside analogues) has so far been documented to reduce viral load and increase CD4 lymphocytes in patients with CD4 cell counts below 500 cells/mm
Croatian: Dosad je dokazano da liječenje indinavirom samim ili u kombinaciji s drugim antiretrovirusnim lijekovima (npr. nukleozidnim analozima) smanjuje virusno opterećenje i povećava broj CD4 limfocita u bolesnika s vrijednošću CD4 limfocita manjom od 500 stanica/mm
English: What CRIXIVAN is
Croatian: Što je CRIXIVAN
English: Similarly, in antiretroviral naive patients, indinavir with and without zidovudine compared with zidovudine alone reduced the probability of ADID at 48 weeks from 15 % with zidovudine alone to approximately 6 % with indinavir alone or in combination with zidovudine.
Croatian: Slično tomu, u bolesnika koji prethodno nisu bili liječeni antiretrovirusnim lijekovima, indinavir u kombinaciji sa zidovudinom ili bez njega je, u usporedbi sa zidovudinom primijenjenim samostalno, u 48. tjednu smanjio vjerojatnost pojave bolesti ili smrti povezane s AIDS-om s 15% kod primjene samo zidovudina na približno 6% kod primjene indinavira samog ili u kombinaciji sa zidovudinom.
English: • The other ingredients are anhydrous lactose, magnesium stearate, gelatin and titanium dioxide (E 171).
Croatian: • Drugi sastojci su bezvodna laktoza, magnezijev stearat, želatina i titanijev dioksid (E171).
English: headache, dizziness insomnia, hypoaesthesia; paraesthesia oral paraesthesia.
Croatian: glavobolja, omaglica nesanica, hipoestezija, parestezija oralna parestezija
English: Medicinal product resistance
Croatian: Rezistencija na lijek
English: Interactions between indinavir/ritonavir and other medicinal products are listed in the tables below (increase is indicated as “↑”, decrease as “↓”, no change (≤ +/- 20 %) as “↔”, single dose as “SD”, once daily as “QD”, twice daily as “BID”, three times daily as “TID”, and four times daily as "QID").
Croatian: Interakcije između indinavira/ritonavira i drugih lijekova navedene su u tablicama koje slijede (porast je označen kao "↑", smanjenje kao "↓", nepromijenjeno stanje (≤ +/- 20%) kao "↔", jedna doza kao "SD", doziranje jedanput na dan kao "QD", doziranje dvaput na dan kao "BID", doziranje triput na dan kao "TID" i doziranje četiri puta na dan kao "QID").
English: Indinavir:  (Relative to Indinavir 800 mg SD alone) Didanosine: 
Croatian: indinavir:  (u odnosu na primjenu samo indinavira u dozi od 800 mg SD) didanozin: 
English: Indinavir boosted regimen.
Croatian: Liječenje pojačanim indinavirom.
English: Patients with mild-to-moderate hepatic insufficiency due to cirrhosis will require a dose reduction of indinavir due to decreased metabolism of indinavir (see section 4.2).
Croatian: U bolesnika s blagom do umjerenom insuficijencijom jetre koja je posljedica ciroze potrebno je sniziti dozu indinavira zbog smanjenog metabolizma indinavira (vidjeti dio 4.2).
English:  atorvastatin concentration Atorvastatin is less dependent on CYP3A4 for metabolism than lovastatin or simvastatin
Croatian: Metabolizam atorvastatina manje ovisi o CYP3A4 nego metabolizam lovastatina ili simvastatina.
English: increases in MCV, decreases in neutrophils increased spontaneous bleeding in patients with haemophilia, anemia including acute haemolytic anaemia, thrombocytopenia (see section 4.4).
Croatian: povećanje srednjeg staničnog volumena (MCV), smanjenje broja neutrofila pojačano spontano krvarenje u bolesnika s hemofilijom, anemija uključujući i akutnu hemolitičku anemiju, trombocitopenija (vidjeti dio 4.4)
English: Sulphamethoxazole/ Trimethoprim 800 mg/160 mg BID (Indinavir 400 mg QID)
Croatian: Sulfametoksazol/trimetoprim 800 mg/160 mg BID (indinavir 400 mg QID)
English: Interaction with indinavir/ritonavir not studied R-warfarin levels may be decreased leading to reduced anticoagulation due to induction of CYP1A2 and CYP2C9 by ritonavir.
Croatian: Koncentracije R-varfarina mogu biti snižene, što dovodi do smanjenja antikoagulacije zbog indukcije CYP1A2 i CYP2C9 ritonavirom.
English: myalgia myositis, rhabdomyolysis, increased CPK, osteonecrosis (see section 4.4), periarthritis.
Croatian: mialgija miozitis, rabdomioliza, povišene vrijednosti kreatin fosfokinaze, osteonekroza (vidjeti dio 4.4), periartritis
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment.
Croatian: U uvjetima imunološke reaktivacije prijavljeni su i autoimuni poremećaji (kao što je Gravesova bolest i autoimuni hepatitis); međutim, prijavljeno vrijeme do pojave je različito i ti se događaji mogu javiti više mjeseci nakon uvođenja liječenja.
English: Amprenavir 600 mg BID AUC ↑ 64 % with 100 mg BID ritonavir alone (relative to amprenavir 1,200 mg BID alone).
Croatian: Amprenavir 600 mg BID AUC ↑ 64% kad se primjenjuje samo s ritonavirom u dozi od 100 mg BID (u odnosu na primjenu samo amprenavira u dozi od 1200 mg BID).
English: • kidney problems (including inflammation of the kidneys, kidney stones, or back pain with or without blood in your urine)
Croatian: • tegobe s bubrezima (uključujući upalu bubrega, bubrežne kamence ili bol u leđima koja može, ali i ne mora biti praćena krvlju u mokraći)
English: If co-administered with ritonavir, CRIXIVAN may be administered with or without food.
Croatian: Ako se primjenjuje istodobno s ritonavirom, CRIXIVAN se može uzimati s hranom ili bez nje.
English: The AUC and peak plasma concentrations were generally similar to those previously observed in HIV-infected adults receiving the recommended dose of 800 mg every 8 hours; it should be observed that the plasma concentrations 8 hours post dose were lower.
Croatian: AUC i vršna koncentracija u plazmi u načelu su bili podjednaki onima prethodno primijećenima u odraslih bolesnika zaraženih HIV-om koji su primali preporučenu dozu od 800 mg svakih 8 sati.
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: U bolesnika zaraženih virusom HIV-a s teškom imunodeficijencijom u trenutku uvođenja kombinirane antiretrovirusne terapije može se razviti upalna reakcija na asimptomatske ili rezidualne oportunističke infekcije.
English: Patients with mild-to-moderate hepatic insufficiency and clinical evidence of cirrhosis had evidence of decreased metabolism of indinavir resulting in approximately 60 % higher mean AUC following a 400-mg dose.
Croatian: U bolesnika s blagom do umjerenom insuficijencijom jetre i kliničkim dokazima ciroze zabilježen je smanjen metabolizam indinavira, što je nakon primjene doze od 400 mg dovelo povišenja srednjeg AUC-a za približno 60%.
English: In this open label nonrandomized single arm study, patients were treated with stavudine and lamivudine plus indinavir/ritonavir 400/100 mg every 12 hours.
Croatian: U tom otvorenom, nerandomiziranom ispitivanju s jednom skupinom bolesnici su liječeni stavudinom i lamivudinom u kombinaciji s indinavirom/ritonavirom u dozi od 400/100 mg svakih 12 sati.
English: Clinical adverse reactions reported by the investigators as possibly, probably, or definitely related to CRIXIVAN in  5 % of patients treated with CRIXIVAN monotherapy or in combination with NRTI(s) (n = 309) for 24 weeks are listed below.
Croatian: U nastavku su navedene kliničke nuspojave za koje su ispitivači procijenili da su možda, vjerojatno ili sigurno povezane s primjenom lijeka CRIXIVAN, u ≥ 5% bolesnika liječenih lijekom CRIXIVAN u monoterapiji ili u kombinaciji s jednim ili više NRTI-ja (n = 309) tijekom 24 tjedna.
English: • phenobarbital, phenytoin, carbamazepine, divalproex, lamotrigine - medicines used to treat fits (epilepsy)
Croatian: • fenobarbital, fenitoin, karbamazepin, divalproeks, lamotrigin - lijekovi za liječenje napadaja
English: Indinavir inhibits CYP3A4 and as a result is expected to markedly increase the plasma concentrations of these HMG-CoA reductase inhibitors, which are highly dependent on CYP3A4 metabolism.
Croatian: Indinavir inhibira CYP3A4 pa se očekuje da bi mogao značajno povisiti plazmatske koncentracije ovih inhibitora HMG-CoA reduktaze koji uvelike ovise o metabolizmu posredovanom CYP3A4.
English: In patients with mild-to-moderate hepatic impairment due to cirrhosis, the dose of indinavir should be reduced to 600 mg every 8 hours.
Croatian: U bolesnika s blagim do umjerenim oštećenjem funkcije jetre koje je posljedica ciroze, dozu indinavira treba smanjiti na 600 mg svakih 8 sati.
English: Interactions and dose recommendations with other medical products - INDINAVIR BOOSTED WITH RITONAVIR.
Croatian: Tablica 2. Interakcije i preporučene doze kod primjene s drugim lijekovima - INDINAVIR POJAČAN RITONAVIROM.
English: Cyclosporine A (CsA) levels markedly increase in patients on PIs, including indinavir.
Croatian: Koncentracije ciklosporina A (CsA) značajno su povišene u bolesnika koji primaju inhibitore proteaze, uključujući indinavir.
English: When to take
Croatian: Kada uzeti lijek
English: Indinavir alone or in combination with nucleoside analogues (zidovudine/stavudine and lamivudine) has been shown to delay clinical progression rate compared with nucleoside analogues and to provide a sustained effect on viral load and CD4 count.
Croatian: Pokazalo se da indinavir primijenjen sam ili u kombinaciji s nukleozidnim analozima (zidovudin/stavudin i lamivudin) usporava kliničku progresiju u odnosu na nukleozidne analoge te ostvaruje održan učinak na virusno opterećenje i broj CD4 stanica.
English: IMMUNOSUPPRESSIVES Cyclosporine A (Indinavir/ritonavir 800/100 BID)
Croatian: Ciklosporin A (indinavir/ritonavir 800/100 BID)
English: Ritonavir oral solution should not be coadministered with amprenavir oral solution to children due to the risk of toxicity from excipients in the two formulations.
Croatian: U djece se ritonavir oralna otopina ne smije primjenjivati istodobno s amprenavir oralnom otopinom zbog rizika od toksičnosti izazvane pomoćnim tvarima u tim pripravcima.
English: Indinavir AUC: ↔
Croatian: AUC indinavira: ↔
English: isolated asymptomatic hyperbilirubinaemia, increased ALT and AST
Croatian: izolirana asimptomatska hiperbilirubinemija, povišene vrijednosti ALT-a i AST-a poremećaj funkcije jetre
English: Rifabutin AUC: ↑ 173 % Rifabutin Cmin: ↑ 244 % (Relative to rifabutin 300 mg QD alone)
Croatian: AUC rifabutina: ↑ 173% Cmin rifabutina: ↑ 244% (u odnosu na primjenu samo rifabutina u dozi od 300 mg QD)
English: Loratidine
Croatian: Loratadin
English: Interaction not studied
Croatian: Interakcija nije ispitana
English: Mean urinary excretion of unchanged medicinal product following single dose administration in the fasted state was 10.4 % following a 700-mg dose, and 12.0 % following a 1,000-mg dose.
Croatian: Nakon primjene jedne doze od 700 mg natašte mokraćom se u nepromijenjenom obliku izlučilo prosječno 10,4% lijeka, a nakon jedne doze od 1000 mg natašte prosječno 12,0% lijeka.
English: Ritonavir increases the serum levels of amprenavir as a result of CYP3A4 inhibition.
Croatian: Ritonavir povisuje koncentracije amprenavira u serumu zbog inhibicije CYP3A4.
English: In HIV-infected paediatric patients, the pharmacokinetic parameters of indinavir in apple sauce were: AUC0-8hr of 26,980 nM*h; peak plasma concentration of 13,711 nM; and plasma concentration at 8 hours post dose of 146 nM.
Croatian: U pedijatrijskih bolesnika zaraženih HIV-om farmakokinetički parametri indinavira u jabučnom soku bili su: AUC0-8h = 26 980 nM*h; vršna koncentracija u plazmi = 13 711 nM; koncentracija u plazmi 8 sati nakon primjene doze = 146 nM.
English: • kidney problems such as kidney infection, worsening or loss of kidney function
Croatian: • tegobe s bubrezima, poput infekcije bubrega, pogoršanja ili gubitka funkcije bubrega • bol i poteškoće pri pomicanju ramena.
English: Rifabutin AUC*: ↑ 54 % Rifabutin Cmin*: ↑ 99 % (*Relative to rifabutin 300 mg QD alone.
Croatian: AUC* rifabutina: ↑ 54% Cmin* rifabutina: ↑ 99% (*u odnosu na primjenu samo rifabutina u dozi od 300 mg QD.
English: Interaction with indinavir/ritonavir Not studied, combined administrations are expected to significantly increase concentrations of midazolam, particularly when midazolam is given orally (CYP3A4 inhibition).
Croatian: Interakcija s indinavirom/ritonavirom nije ispitivana, ali se očekuje da će kombinirana primjena dovesti do značajnih povišenja koncentracija midazolama, naročito kad se midazolam primjenjuje peroralno (inhibicija CYP3A4).
English: Indinavir AUC: 
Croatian: AUC indinavira: 
English: The metabolism of indinavir is mediated by the cytochrome P450 enzyme CYP3A4.
Croatian: Metabolizam indinavira posredovan je enzimom CYP3A4 citokroma P450.
English: - rifampicin - an antibiotic used to treat infections - cisapride - used for gut problems - amiodarone - used for heart rhythm problems - pimozide - used for some mental health problems - lovastatin or simvastatin - used to lower cholesterol - St. John's wort (Hypericum perforatum) - a herbal medicine used for depression - ergot tartramine (with or without caffeine) - used for migraines - astemizole or terfenadine - antihistamines used for hay fever and other allergies - quetiapine - used for some mental illnesses such as schizophrenia, bipolar disorder and major depressive disorder - alprazolam, triazolam and midazolam (by mouth) - used to make you calmer or help you sleep.
Croatian: - pimozid - koristi se za neke tegobe s psihičkim zdravljem - lovastatin ili simvastatin - koriste se za snižavanje kolesterola - gospinu travu (Hypericum perforatum) - biljni lijek koji se koristi za depresiju - ergot tartramin (s kofeinom ili bez njega) - koristi se za migrenu - astemizol ili terfenadin - antihistaminici koji se koriste za liječenje peludne groznice i drugih alergija - kvetiapin - koristi se za liječenje psihičkih bolesti poput shizofrenije, bipolarnog poremećaja te velikog depresivnog poremećaja - alprazolam, triazolam i midazolam (kroz usta) - koriste se za umirenje ili da lakše zaspete
English: Diltiazem AUC0-24hr:  43 % Indinavir/ritonavir AUCs: 
Croatian: AUC0-24h diltiazema:  43% AUC indinavira/ritonavira: 
English: Caution must also be exercised if indinavir is used concurrently with atorvastatin.
Croatian: Oprez je nužan i ako se indinavir primjenjuje istodobno s atorvastatinom.
English:  dihydropyridine calcium channel blocker concentration
Croatian:  koncentracija dihidropiridinskih blokatora kalcijevih kanala
English: Dose increases of indinavir/ritonavir when given in combination with efavirenz have not been studied.
Croatian: Nisu ispitivana povećanja doze indinavira/ritonavira kod istodobne primjene s efavirenzom.
English: Due to CYP3A inhibition by indinavir, concentrations of quetiapine are expected to increase.
Croatian: Zbog inhibicije CYP3A indinavirom očekuje se povišenje koncentracija kvetiapina.
English: Inhibition of CYP3A4 by both CRIXIVAN and ritonavir could result in elevated plasma concentrations of these medicines, potentially causing serious or life-threatening reactions.
Croatian: Inhibicija CYP3A4 koju uzrokuju i CRIXIVAN i ritonavir može dovesti do povišenih koncentracija tih lijekova u plazmi i tako potencijalno izazvati ozbiljne ili po život opasne reakcije.
English: Evaluation may consist of urinalysis, serum BUN and creatinine, and ultrasound of the bladder and kidneys.
Croatian: Procjena može obuhvatiti analizu urina, dušika iz ureje u krvi i kreatinin u serumu te ultrazvuk mokraćnog mjehura i bubrega.
English: Therefore coadministration is not recommended.
Croatian: Stoga se istodobna primjena ne preporučuje.