FrancophonIA/ELRC3.0 huggingface dataset:
English: If accidental exposure to the eyes occurs, the eyes should be rinsed with water and in case of accidental exposure to the skin, the skin should be washed with soap and water.
Croatian: U slučaju nehotičnog dodira s očima, oči treba isprati vodom, a u slučaju nehotičnog dodira s kožom, kožu treba oprati sapunom i vodom.
English: (S)-methoprene is an insect growth regulator which stops the flea life cycle by killing eggs and blocking the development of juvenile flea stages and causing their death.
Croatian: (S)-metopren regulator je rasta kukaca koji prekida životni ciklus buha tako što uništava jajašca i sprječava razvoj nezrelih stadija buhe te uzrokuje njihovu smrt.
English: What are the risks associated with Broadline?
Croatian: Koji su rizici povezani s VMP-om Broadline?
English: It may also be used as part of a treatment strategy for flea allergy dermatitis (an allergic reaction to flea bites).
Croatian: Može se primjenjivati i kao dio strateškog tretmana alergijskog dermatitisa uzrokovanog buhama (alergijske reakcije na ugrize buha).
English: An overview of Broadline and why it is authorised in the EU
Croatian: Pregled informacija o VMP-u Broadline i zašto je odobren u EU-u
English: People with known hypersensitivity to any of the ingredients should avoid contact with the product.
Croatian: Osobe s poznatom preosjetljivošću na bilo koju od djelatnih ili pomoćnih tvari trebaju izbjegavati kontakt s VMP-om.
English: The measure of effectiveness was reduction of the number of Notoedres cati mites found in skin scrapings compared to cats that received no treatment.
Croatian: Mjerilo djelotvornosti bilo je smanjenje broja grinja Notoedres cati pronađenih u strugotinama kože u usporedbi s mačkama koje nisu bile tretirane.
English: How does Broadline work?
Croatian: Kako djeluje Broadline?
English: Broadline (fipronil/(S)methoprene/eprinomectin/praziquantel)
Croatian: Broadline (fipronil/(S)metopren/eprinomektin/prazikvantel)
English: The European Medicine Agency decided that Broadline's benefits are greater than its risks and it can be authorised for use in the EU.
Croatian: Europska agencija za lijekove zaključila je da koristi od VMP-a Broadline nadmašuju s njim povezane rizike te da VMP može biti odobren za primjenu u Europskoj uniji.
English: Broadline was more than 90% effective in reducing lungworm larvae at 28 days after treatment and all treated cats showing respiratory signs (such as wheezing, persistent coughing and a runny nose) were clinically cured.
Croatian: VMP Broadline bio je djelotvoran iznad 90 % u smanjenju broja ličinaka 28 dana nakon tretmana, a sve tretirane mačke koje su imale respiratorne simptome (poput piskanja pri disanju, ustrajnog kašlja i curenja nosa) bile su kliničke izliječene.
English: Broadline was 100% effective against the L4 larval stage of heartworm.
Croatian: VMP Broadline bio je 100 % djelotvoran protiv ličinke srčane gliste u razvojnom stadiju L4.
English: Why is Broadline authorised in the EU?
Croatian: Zašto je VMP Broadline odobren u EU-u?
English: If a cat swallows the medicine, it may result in vomiting (being sick) and/or short-lived effects on the nervous system, shown by signs such as lack of muscular coordination, disorientation, lack of interest in surroundings and pupil dilation.
Croatian: Ako mačka proguta VMP, to može uzrokovati povraćanje (mučninu) ili kratkotrajne učinke na živčani sustav, koji se manifestiraju kao nedostatak mišićne koordinacije, dezorijentiranost, nedostatak zanimanja za okolinu i proširenje zjenica.
English: Twenty cats naturally infested with lungworm were treated with Broadline.
Croatian: Dvadeset mačaka prirodno infestiranih plućnim oblićima tretirano je VMP-om Broadline.
English: The product is to be used only when all three groups of parasites are targeted at the same time.
Croatian: VMP se primjenjuje samo ako je istovremeno indiciran tretman protiv svih triju skupina parazita.
English: For external parasites, Broadline treats flea infestations and prevents new infestations for at least one month; it also prevents environmental flea contamination for over a month.
Croatian: U slučaju vanjskih parazita, primjenom VMP-a Broadline tretiraju se infestacije buhama i sprječavaju nove infestacije tijekom najmanje mjesec dana, a sprječava se i kontaminacija okoliša buhama tijekom razdoblja dužeg od mjesec dana.
English: The study showed effectiveness of 86 to 87% against adult fleas for Broadline throughout the 30 day post-treatment period compared with between 76 and 82% for cats treated with another medicine containing just fipronil and (S)-methoprene.
Croatian: Ispitivanjem je dokazana djelotvornost VMP-a Broadline protiv odraslih buha od 86 do 87 % tijekom cijelog 30dnevnog razdoblja nakon terapije, dok je u mačaka tretiranih drugim VMP-om koji sadrži samo fipronil i (S)-metopren bila između 76 i 82 %.
English: Broadline is available as a spot-on solution in applicators of two different volume sizes for use in cats of various bodyweights and can only be obtained with a prescription.
Croatian: Broadline je dostupan u obliku otopine za nakapavanje u aplikatorima dviju različitih veličina za primjenu u mačaka različitih tjelesnih težina, a izdaje se samo na veterinarski recept.
English: How is Broadline used?
Croatian: Kako se Broadline koristi?
English: Broadline-treated cats were compared to cats treated with a spot-on product containing the worm medicines emodepside and praziquantel.
Croatian: Mačke tretirane VMP-om Broadline uspoređene su s mačkama koje su tretirane proizvodom za nakapavanje koji sadrži djelatne tvari emodepsid i prazikvantel.
English: For ticks, effectiveness was between 85 and 93% for Broadline-treated cats compared with 92 and 98% for cats treated with the comparator product.
Croatian: U slučaju krpelja, djelotvornost je bila između 85 i 93 % u mačaka tretiranih VMP-om Broadline, dok je u mačaka tretiranih usporednim VMP-om o bila između 92 i 98 %.
English: Eprinomectin interferes with channels in the nerve and muscle cells of roundworms that allow charged chloride particles (ions) to pass, leading to their paralysis and death.
Croatian: Eprinomektin začepljuje kanale unutar živčanih i mišićnih stanica oblića kojima prolaze nabijene čestice (ioni) klorida, čime uzrokuje njihovu paralizu i smrt.
English: Praziquantel acts on the cell membranes of tapeworms, leading to the death of the parasite.
Croatian: Prazikvantel djeluje na stanične membrane trakavica i na taj način uzrokuje smrt parazita.
English: The study showed almost 100% effectiveness against tapeworms, roundworms and hookworms for both Broadline and the comparator product.
Croatian: Ispitivanjem je utvrđena djelotvornost od gotovo 100 % protiv trakavica, oblića i kukastih crva i VMP-a Broadline i usporednog proizvoda.
English: Broadline is a veterinary medicine used to treat cats with, or at risk of, mixed infestations by tapeworms, roundworms and external parasites (fleas, ticks, and a burrowing mite called Notoedres cati which is a cause of mange).
Croatian: Broadline je veterinarsko-medicinski proizvod koji se koristi za tretman mačaka koje imaju ili su u opasnosti da dobiju mješovite infestacije trakavicama, oblićima i vanjskim parazitima (buhama, krpeljima i ušnim grinjama naziva Notoedres cati koje su uzročnici šuge).
English: The effectiveness of Broadline against cat mange was examined in a laboratory study with 18 naturally infested cats.
Croatian: Djelotvornost VMP-a Broadline protiv mačje šuge ispitana je u laboratorijskom ispitivanju provedenom na 18 prirodno infestiranih mačaka.
English: The main measure of effectiveness was reduction of numbers of worm larvae in faeces at 28 days after single treatment.
Croatian: Glavno mjerilo djelotvornosti bilo je smanjenje broja ličinaka u izmetu 28 dana nakon tretmana.
English: Broadline can also be used to prevent heartworm disease for one month.
Croatian: Broadline se može primjenjivati i za sprječavanje dirofilarioze (bolesti uzrokovane srčanom glistom) tijekom mjesec dana.
English: If eye irritation persists, or if side effects are noticed, medical advice should be sought and the package leaflet or label shown to the doctor.
Croatian: Ako nadraženost očiju ne prestaje ili ako se primijete nuspojave, treba potražiti savjet liječnika i ponijeti sa sobom uputu o VMPu ili naljepnicu.
English: The study showed over 98% effectiveness of the medicine against the mite, with a clinical cure in all animals.
Croatian: Ispitivanjem je utvrđena djelotvornost VMP-a protiv grinja iznad 98 %, uz kliničko izlječenje svih životinja.
English: Effectiveness was measured by identifying adult worm segments (tapeworms) or counting worm eggs (roundworms) in faeces at day 14 after treatment.
Croatian: Djelotvornost je mjerena utvrđivanjem članaka odraslih trakavica ili brojanjem jajašaca oblića u izmetu 14. dana nakon terapije.
English: Broadline contains four active substances: fipronil, (S)-methoprene, eprinomectin and praziquantel.
Croatian: Broadline sadrži četiri djelatne tvari: fipronil, (S)-metopren, eprinomektin i prazikvantel.
English: Mild and short-lived skin reactions (itching, hair loss) may occur at the application site.
Croatian: Na mjestu primjene mogu se pojaviti blage i kratkotrajne kožne reakcije (svrbež, gubitak dlake).
English: The other two active substances in Broadline, eprinomectin and praziquantel, act as ‘endoparasiticides'.
Croatian: Druge dvije djelatne tvari VMP-a Broadline, eprinomektin i prazikvantel, djeluju kao „endoparaziticidi”.
English: The effectiveness of Broadline against feline lungworm was investigated in a field study in Italy.
Croatian: Djelotvornost VMP-a Broadline protiv mačjih plućnih oblića ispitana je tijekom terenskog ispitivanja u Italiji.
English: For more information about using Broadline, see the package leaflet or contact your veterinarian or pharmacist.
Croatian: Više informacija o primjeni VMP-a Broadline pročitajte u uputi o VMP-u, odnosno obratite se veterinaru ili ljekarniku.
English: What benefits of Broadline have been shown in studies?
Croatian: Koje su koristi od VMP-a Broadline utvrđene u ispitivanjima?
English: For worms, Broadline is used to treat tapeworms, roundworms and hookworms in the gut as well as a type of worm that infects the bladder and two types of feline lungworm.
Croatian: U slučaju glista, Broadline se primjenjuje za tretman infestacija trakavicama, oblićima i kukastim crvima u crijevima, kao i vrstom oblića koja infestira mokraćni mjehur te dvama vrstama mačjih plućnih oblića.
English: Two of the active substances in Broadline, fipronil and (S)-methoprene, act as ‘ectoparasiticides'.
Croatian: Dvije djelatne tvari VMP-a Broadline, fipronil i (S)-metopren, djeluju kao „ektoparaziticidi”.
English: The effectiveness of Broadline against fleas and ticks was investigated in an EU field study involving cats infested with fleas, ticks, or both.
Croatian: Djelotvornost VMP-a Broadline protiv buha i krpelja ispitivana je u terenskom ispitivanju na području EU-a kojim su bile obuhvaćene mačke infestirane buhama, krpeljima ili obama parazitima.
English: The effectiveness of Broadline to prevent heartworm disease was shown in three laboratory studies, using artificially infected cats.
Croatian: Djelotvornost VMP-a Broadline su suzbijanju dirofilarioze utvrđena je u trima laboratorijskim ispitivanjima koja su provedena na umjetno infestiranim mačkama.
English: The effectiveness of Broadline against intestinal worms was investigated in one EU field study involving cats with tapeworm, roundworm or hookworm infections or mixed infections.
Croatian: Djelotvornost VMP-a Broadline protiv crijevnih oblića ispitivana je u terenskom ispitivanju na području EU-a kojim su bile obuhvaćene mačke zaražene trakavicama, oblićima ili kukastim crvima, odnosno obama parazitima.
English: It blocks channels in their nerve cells that allow charged chloride particles (ions) to pass, interfering with the transmission of nerve signals and leading to overstimulation and death.
Croatian: Na taj način ometa prijenos živčanih signala, uzrokuje prekomjernu stimulaciju i smrt.
English: Survival time in months
Croatian: Vrijeme preživljenja u mjesecima
English: Glivec can help you to fight this condition.
Croatian: Glivec Vam može pomoći u borbi protiv tog stanja.
English: If you take more Glivec than you should
Croatian: Ako uzmete više Gliveca nego što ste trebali
English: Date of first authorisation: 07 November 2001 Date of latest renewal: 07 November 2006
Croatian: Datum prvog odobrenja: 7. studenog 2001. Datum posljednje obnove odobrenja: 7. studenog 2006.
English: Glivec may do the same to some other medicines.
Croatian: Glivec može to isto napraviti nekim drugim lijekovima.
English: They have “glivec” on one side.
Croatian: Imaju oznaku „glivec“ na jednoj strani.
English: The safety database for children with Ph+ALL is very limited though no new safety concerns have been identified.
Croatian: Baza sigurnosnih podataka za djecu s Ph+ALL vrlo je ograničena iako nisu uočena nikakva nova sigurnosna pitanja.
English: Risk criteria
Croatian: Kriterij rizika
English: Your doctor has prescribed Glivec because you suffer from a serious condition.
Croatian: Vaš liječnik je propisao Glivec, jer patite od ozbiljnog stanja.
English: Glivec can reduce the number of white blood cells, so you might get infections more easily.
Croatian: Glivec može smanjiti broj bijelih krvnih stanica, pa možete lakše dobiti infekciju.
English: They contain a white to yellow powder.
Croatian: Sadrže bijeli do žuti prašak.
English: Return to chronic phase (RTC)
Croatian: Vraćanje na kroničnu fazu (RTC)
English: The amount of Glivec given will depend on your child's condition, body weight and height.
Croatian: Količina Gliveca koju je potrebno dati ovisiti će o stanju djeteta, tjelesnoj težini i visini.
English: Submission of final study report.
Croatian: Predaja izvješća završnog ispitivanja.
English: Probability of overall survival
Croatian: Vjerojatnost ukupnog preživljenja
English: Molecular response**
Croatian: Molekularni odgovor **
English: When and how to take Glivec - Take Glivec with a meal.
Croatian: Kada i kako uzimati Glivec - Glivec uzimajte uz obrok.
English: Older people: Imatinib pharmacokinetics have not been specifically studied in older people.
Croatian: Stariji ljudi: farmakokinetika imatiniba nije specifično ispitivana u starijih ljudi.
English: What Glivec is and what it is used for
Croatian: Što je Glivec i za što se koristi
English: Do not take Glivec: - if you are allergic to imatinib or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati Glivec: - ako ste alergični na imatinib ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Some children and adolescents taking Glivec may have slower than normal growth.
Croatian: Kod neke djece i adolescenata koji uzimaju Glivec rast može biti sporiji od normalnog.
English: Do not stop taking Glivec unless your doctor tells you to.
Croatian: Nemojte prestati uzimati Glivec, osim ako Vam to ne kaže liječnik.
English: -- (1) Imatinib 12 MO:
Croatian: -- (1) Imatinib 12 mj.:
English: You may become more sensitive to the sun while taking Glivec.
Croatian: Možete postati osjetljiviji na sunce tijekom uzimanja Gliveca.
English: Therefore, the use of Glivec in combination requires special precaution.
Croatian: Stoga primjena Gliveca u kombinaciji zahtijeva posebne mjere opreza.
English: 9/l) were observed in 3.6% and < 1% of patients, respectively.
Croatian: 9/l) zapažene su u 3,6% odnosno <1% bolesnika.
English: 9/l unrelated to therapy.
Croatian: 9/l nevezano uz terapiju.
English: Table 6 Best tumour response in trial STIB2222 (GIST)
Croatian: Tablica 6 Najbolji tumorski odgovor u ispitivanju STIB2222 (GIST)
English: The Kaplan-Meier estimate for survival after 36-month follow-up is 68%.
Croatian: Kaplan-Meierova procjena za preživljenje nakon 36mjesečnog praćenja iznosi 68%.
English: NIH Low
Croatian: NIH Niska
English: While you are taking Glivec, your doctor will regularly check whether the medicine is working.
Croatian: Dok uzimate Glivec, liječnik će redovito pratiti da li lijek djeluje.
English: Treatment with Glivec may be interrupted or the dose may be reduced, as recommended in section 4.2.
Croatian: Liječenje Glivecom može se prekinuti ili se doza može smanjiti, kao što se preporučuje u dijelu 4.2.
English: If you have any questions about how Glivec works or why this medicine has been prescribed for you, ask your doctor.
Croatian: Ako imate bilo kakvih pitanja o tome na koji način djeluje Glivec, ili zašto je taj lijek Vama propisan, obratite se svom liječniku.
English: PVC/aluminium blisters
Croatian: PVC/aluminij blisteri
English: They are supplied in packs containing 30 capsules.
Croatian: Nalaze se u pakiranjima koja sadrže 30 kapsula.
English: What you need to know before you take Glivec
Croatian: Što morate znati prije nego počnete uzimati Glivec
English: During treatment with Glivec, tell your doctor straight away if you put on weight very quickly.
Croatian: Tijekom liječenja Glivecom odmah obavijestite svog liječnika ako vrlo brzo dobivate na težini.
English: Other medicines and Glivec
Croatian: Drugi lijekovi i Glivec
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription (such as paracetamol) and including herbal medicines (such as St. John's Wort).
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući lijekove dobivene bez recepta (poput paracetamola) i biljne pripravke (poput gospine trave).
English: Results are provided in Table 6.
Croatian: Rezultati su prikazani u Tablici 6.
English: (2) Imatinib 36 MO: │││ Censored observations
Croatian: (2) Imatinib 36 mj.: │││ Cenzurirana opažanja
English: When needed, discontinuation of Glivec treatment may be considered.
Croatian: Ukoliko je potrebno, može se razmotriti prekid liječenja Glivecom.
English: IU/week and were all in late chronic phase, with a median time from diagnosis of 32 months.
Croatian: IU/tjedan i svi su bili u završnoj kroničnoj fazi, sa medijanom vremena od postavljanja dijagnoze od 32 mjeseca.
English: • Unexpected bleeding or bruising (when you have not hurt yourself).
Croatian: • neočekivano krvarenje ili pojava modrica (kada se niste ozlijedili).
English: 4 cycles
Croatian: 4 ciklusa
English: How long to take Glivec Keep taking Glivec every day for as long as your doctor tells you.
Croatian: Koliko dugo uzimati Glivec Glivec nastavite uzimati svaki dan onoliko dugo koliko Vam je liječnik rekao.
English: Glivec may cause your body to retain water (severe fluid retention).
Croatian: Glivec može izazvati zadržavanje vode u tijelu (teška retencija tekućine).
English: Treatment with Glivec may then be continued at a reduced daily dose.
Croatian: Tada se liječenje Glivecom može nastaviti uz sniženu dnevnu dozu.
English: Some medicines can interfere with the effect of Glivec when taken together.
Croatian: Neki lijekovi mogu utjecati na djelovanje Gliveca kada se uzimaju zajedno.
English: At-risk : Events
Croatian: Broj izloženih riziku : broj događaja
English: In all clinical studies 38-40% of patients were  60 years of age and 10-12% of patients were  70 years of age.
Croatian: U svim kliničkim ispitivanjima 38-40% bolesnika bilo je u dobi ≥60 godina, a 10-12% bolesnika bilo je u dobi ≥70 godina.
English: The results of subgroup analyses according to the United States National Institutes of Health (NIH) and the Armed Forces Institute of Pathology (AFIP) risk classifications are shown in Table 7.
Croatian: Rezultati analize podskupine bolesnika razvrstane prema klasifikacijama rizika američkog Nacionalnog instituta za zdravstvo (NIH - National Institutes of Health) i Instituta za patologiju američkih oružanih snaga (AFIP - Armed Forces Institute of Pathology) su prikazani u Tablici 7.
English: The translocation t(17:22)[(q22:q13)], or its gene product, was present in nearly all responders to Glivec treatment.
Croatian: Translokacija t(17:22)[(q22:q13)], ili njezin genski proizvod, je bila prisutna kod gotovo svih bolesnika koji su odgovorili na liječenje Glivecom.
English: It is important to cover sun-exposed areas of skin and use sunscreen with high sun protection factor (SPF).
Croatian: Važno je pokriti područja kože izložena suncu i koristiti sredstvo za zaštitu od sunca s visokim zaštitnim faktorom (SPF).
English: If this applies to you, tell your doctor without taking Glivec.
Croatian: Ako se to odnosi na Vas, obavijestite svog liječnika bez uzimanja Gliveca.
English: Glivec should not be used during pregnancy unless clearly necessary.
Croatian: - Glivec se ne smije upotrebljavati tijekom trudnoće, osim ako to nije neophodno.
English: Figure 2 Kaplan-Meier estimates for overall survival (ITT population)
Croatian: Slika 2 Kaplan-Meierova procjena ukupnog preživljenja (ITT populacija)
English: * These types of reactions have been reported mainly from post-marketing experience with Glivec.
Croatian: * Ove vrste reakcija zabilježene su uglavnom nakon stavljanja Gliveca u promet.
English: Mean absolute bioavailability for the capsule formulation is 98%.
Croatian: Srednja apsolutna bioraspoloživost za formulaciju kapsula je 98%.
English: Major cytogenetic response Complete (Confirmed
Croatian: Veliki citogenetski odgovor Potpuni (Potvrđeni
English: The degree of cytogenetic response and molecular response had a clear effect on long-term outcomes in patients on Glivec.
Croatian: Stupanj citogenetskog odgovora i molekularnog odgovora imao je jasan učinak na dugotrajne ishode u bolesnika na Glivecu.
English: The yearly rates of progression of any type for Glivec also decreased over time.
Croatian: Kod Gliveca su se godišnje stope progresije bilo koje vrste također smanjivale s vremenom.
English: For CML and GIST, your doctor may prescribe a higher or lower dose depending on how you respond to treatment.
Croatian: Za KML ili GIST, liječnik Vam može propisati višu ili nižu dozu, ovisno o tome kako reagirate na liječenje.
English: What Glivec is and what it is used for What you need to know before you take Glivec How to take Glivec
Croatian: Što se nalazi u ovoj uputi Što je Glivec i za što se koristi Što morate znati prije nego počnete uzimati Glivec Kako uzimati Glivec
English: Accelerated phase: 235 adult patients with accelerated phase disease were enrolled.
Croatian: Ubrzana faza: uključeno je 235 odraslih bolesnika s bolešću u ubrzanoj fazi.
English: Glivec is indicated for
Croatian: Glivec je indiciran za
English: There have been post-marketing reports of spontaneous abortions and infant congenital anomalies from women who have taken Glivec.
Croatian: Postoje post-marketinška izvješća o spontanim pobačajima i dojenčadi s kongenitalnim anomalijama u žena koje su uzimale Glivec.
English: These events can usually be managed with either a reduction of the dose or an interruption of treatment with Glivec, but can in rare cases lead to permanent discontinuation of treatment.
Croatian: Te se epizode obično mogu liječiti ili smanjenjem doze ili prekidanjem liječenja Glivecom, no u rijetkim slučajevima mogu dovesti i do trajnog ukidanja liječenja.
English: - Do not breast-feed during the treatment with Glivec.
Croatian: - Nemojte dojiti tijekom liječenja Glivecom.
English: Patients should be tested for HBV infection before initiating treatment with Glivec.
Croatian: Bolesnike je potrebno testirati na infekciju HBV-om prije početka liječenja Glivecom.
English: Frequency categories are defined using the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Kategorije učestalosti se definiraju kao: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: This will help protect you from stomach problems when taking Glivec.
Croatian: To će Vam pomoći u zaštiti od želučanih problema prilikom uzimanja Gliveca.