FrancophonIA/ELRC3.0 huggingface dataset:
English: Severe rash occurred in 1.4 % and 0.2 % of the Viramune immediate-release and Viramune prolonged-release groups respectively during the randomised phase.
Danish: Hos 1,4 % og 0,2 % af de grupper, der fik henholdsvis Viramune 200 mg og Viramune i depotform i randomiseringsfasen, opstod der svært udslæt.
English: The pharmacokinetics of Viramune prolonged-release has also been studied in a multiple dose pharmacokinetics study (study 1100.1489) in 24 HIV-1 infected patients who switched from chronic Viramune immediate-release therapy to Viramune prolonged-release.
Danish: I et flerdosis-farmakokinetisk studie (studie1100.1489) undersøges farmakokinetikken ved Viramune i depotform hos 24 hiv-1-inficerede patienter, der skiftede fra kronisk behandling med Viramune 200 mg til Viramune i depotform.
English: Nevirapine AUC  1.27 (1.12-1.44) Nevirapine Cmin  1.47 (1.20-1.82) Nevirapine Cmax  1.18 (1.02-1.37)
Danish: Nevirapin AUC  1,27 (1,12-1,44) Nevirapin Cmin  1,47 (1,20-1,82) Nevirapin Cmax  1,18 (1,02-1,37)
English: NAME OF THE MEDICINAL PRODUCT Viramune 200 mg tablets
Danish: LÆGEMIDLETS NAVN Viramune 200 mg tabletter
English: Ketoconazole 400 mg QD
Danish: Ketoconazol 400 mg 4 gange daglig
English: Patients with CLcr  20 ml/min do not require a dose adjustment, see section 5.2.
Danish: Ingen dosisjustering til patienter med CLcr  20 ml/min, se pkt.
English: Single dose nevirapine in mothers or infants may lead to reduced efficacy if an HIV treatment regimen using nevirapine is later instituted within 6 months or less in these patients.
Danish: Hvis et hiv-behandlingsregime med nevirapin påbegyndes inden for 6 måneder hos de mødre eller spædbørn, der har fået en enkeltdosis-nevirapin, kan det medføre nedsat effekt.
English: Nevirapine AUC  1.29 (1.19-1.40) Nevirapine Cmin  1.34 (1.21-1.49) Nevirapine Cmax  1.25 (1.14-1.37)
Danish: Nevirapin AUC  1,29 (1,19-1,40) Nevirapin Cmin  1,34 (1,21-1,49) Nevirapin Cmax  1,25 (1,14-1,37)
English: Due to the metabolic pathway of entecavir, no clinically relevant drug-drug interaction is expected.
Danish: På grund af entecavirs metaboliseringsvej forventes ingen klinisk relevant lægemiddelinteraktion.
English: If you notice that you have missed a dose within 8 hours of when it was due, take the missed dose as soon as possible.
Danish: Hvis du inden for 8 timer opdager, at du har glemt en dosis, så tag den glemte dosis hurtigst muligt.
English: - if you have taken Viramune before and had to stop the treatment because you suffered from: - severe skin rash - skin rash with other symptoms for example: - fever - blistering - mouth sores - inflammation of the eye - swelling of the face
Danish: hvis du tidligere har taget Viramune og måtte stoppe behandlingen, fordi du har fået: alvorligt hududslæt hududslæt og samtidig har andre symptomer som - feber - blæredannelse - sår i munden - øjenbetændelse - hævelse i ansigtet
English: These are supplied in the package leaflets for those medicines.
Danish: Du bør også læse indlægssedlerne for disse.
English: If in doubt ask your child's doctor.
Danish: Kontakt dit barns læge i stedet.
English: Rhabdomyolysis has been observed in patients experiencing skin and/or liver reactions associated with Viramune use.
Danish: Rhabdomyolose er observeret hos patienter med hud- og/eller leverpåvirkning i forbindelse med Viramune-behandling.
English: Viramune prolonged-release
Danish: Viramune i depotform
English: MARKETING AUTHORISATION NUMBER(S) EU/1/97/055/001 [60 tablets]
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/97/055/001 [60 tabletter]
English: Fluconazole Cmin  0.93 (0.86-1.01) Fluconazole Cmax  0.92 (0.85-0.99)
Danish: Fluconazol AUC  0,94 (0,88-1,01) Fluconazol Cmin  0,93 (0,86-1,01) Fluconazol Cmax  0,92 (0,85-0,99)
English: Do not use this medicine after the expiry date which is stated on the carton and on the bottle after “EXP”.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på æsken og på flasken efter ”EXP”.
English: 100-150 mg BID
Danish: 100-150 mg 2 gange dagligt
English: For patients with renal dysfunction requiring dialysis an additional 200 mg dose of nevirapine following each dialysis treatment is recommended.
Danish: Det anbefales, at voksne patienter med nedsat nyrefunktion, som har behov for dialyse, får en ekstra dosis nevirapin 200 mg efter hver dialysebehandling.
English: The side effects described below have been experienced by patients given Viramune 200 mg tablets during the 14 day lead-in phase:
Danish: Følgende bivirkninger er set hos patienter i de første 14 behandlingsdage (optrapningsfasen) med Viramune 200 mg:
English: Renal impairment
Danish: Pyreksi, træthed
English: If you are an adult and choose to use another measuring device (e.g. cup or teaspoon) please make sure that you take the whole dose.
Danish: Hvis du er voksen og vælger at bruge andet til afmåling (målebæger eller teske) så vær sikker på, at du får den afmålte dosis, da noget Viramune kan være tilbage i bægeret eller på skeen.
English: LIST OF EXCIPIENTS Contains lactose
Danish: LISTE OVER HJÆLPESTOFFER Indeholder lactose.
English: The prolonged-release tablets are about 9.3 x 19.1 mm, debossed with V04 on one side and the company symbol on the other side.
Danish: Depottabletterne er ca. 9,3 x 19,1 mm i diameter og præget med Boehringer Ingelheims logo og V04.
English: If you stop taking Viramune for more than 7 days your doctor will instruct you to start the 14 day 'lead-in' period (described above) once again, before returning to the twice daily dose.
Danish: Hvis du afbryder behandlingen med Viramune i mere end 7 dage, vil din læge råde dig til at starte igen med en 14 dages "optrapningsfase" (som beskrevet ovenfor), før du igen går over til behandling 2 gange daglig.
English: Tenofovir and Viramune can be coadministered without dose adjustments.
Danish: Tenofovir og Viramune kan coadministreres uden dosisjustering.
English: Viramune tablets contain less than 1 mmol sodium (23 mg) per tablet, that is to say essentially
Danish: Viramune tabletter indeholder mindre end 1 mmol (23 mg) natrium pr. tablet, dvs. de er i det væsentlige natrium-frie.
English: The medicinal product should be used within 2 months of opening.
Danish: Anvendes senest 2 måneder efter åbning.
English: It is very important that your child takes Viramune only once a day for the first 14 days (“lead-in” period).
Danish: Det er meget vigtigt, at dit barn kun får Viramune 1 gang om dagen i de første 14 dage af behandlingen (optrapningsfasen).
English: Itraconazole 200 mg QD
Danish: Itraconazole 200 mg 4 gange dagli
English: Uncommon jaundice, hepatitis fulminant (which may be fatal) Rare hepatitis (incl.
Danish: Gulsot, fulminant hepatitis (som kan være letal)
English: If you are uncertain please be sure to ask your child's doctor or pharmacist.
Danish: Er du i tvivl, så spørg lægen eller apotekspersonalet.
English: Microcrystalline cellulose
Danish: Natriumstivelsesglycolat Kolloid silica
English: Treatment initiation pack
Danish: Vedligeholdelsespakning
English: Viramune prolonged-release tablets should only be used after a two-week treatment with another type of Viramune (immediate-release tablets or suspension) unless you are currently on Viramune and are switching to the prolonged-release form.
Danish: Før du begynder at tage Viramune depottabletter, skal du have været i 14 dages behandling med enten Viramune 200 mg tabletter eller Viramune suspension, medmindre du i forvejen tager Viramune, og skifter behandling til depottabletter.
English: Nevirapine must be permanently discontinued in any patient experiencing hypersensitivity reaction (characterised by rash with constitutional symptoms, plus visceral involvement, such as hepatitis, eosinophilia, granulocytopenia, and renal dysfunction) see section 4.4.
Danish: Nevirapin bør seponeres permanent hos enhver patient, som udvikler overfølsomhedsreaktioner (karakteriseret ved udslæt med konstitutionelle symptomer samt organpåvirkning, såsom hepatitis, eosinofili, granulocytopeni og nyresvigt) (se pkt.
English: Fosamprenavir 1400 mg BID
Danish: Fosamprenavir 1400 mg 2 gange dagligt
English: Patients with moderate to severe elevations (ASAT or ALAT > 5 ULN) should be permanently discontinued from nevirapine.
Danish: Nevirapin bør permanent seponeres hos patienter med moderate til svære stigninger (ASAT eller ALAT > 5 ULN).
English: Severe and life-threatening skin reactions, including fatal cases, have occurred in patients treated with nevirapine mainly during the first 6 weeks of therapy.
Danish: letale tilfælde er forekommet hos patienter behandlet med nevirapin, hovedsagelig i løbet af de første 6 uger af behandlingen.
English: If you notice you missed a dose within 12 hours of when it was due, take the missed dose as soon as possible.
Danish: Hvis du inden for 12 timer opdager, at du har glemt en dosis, så tag den glemte dosis hurtigst muligt.
English: PHARMACEUTICAL FORM AND CONTENTS 90 prolonged-release tablets
Danish: LÆGEMIDDELFORM OG INDHOLD (PAKNINGSSTØRRELSE) 90 depottabletter
English: Nevirapine AUC  1.14 (1.05-1.24) Nevirapine Cmin  1.22 (1.10-1.35) Nevirapine Cmax  1.13 (1.03-1.24)
Danish: Nevirapin AUC  1,14 (1,05-1,24) Nevirapin Cmin  1,22 (1,10-1,35) Nevirapin Cmax  1,13 (1,03-1,24)
English: Common (may affect up to 1 in 10 people): - decreased numbers of white blood cells (granulocytopenia) - allergic reactions (hypersensitivity) - headache - feeling sick (nausea) - vomiting - abdominal pain - loose stools (diarrhoea) - inflammation of the liver (hepatitis) - feeling tired (fatigue) - fever - abnormal liver function tests
Danish: Almindelig (kan forekomme hos op til 1 ud af 10 patienter): - nedsat antal hvide blodlegemer (granulocytopeni) - allergiske reaktioner (overfølsomhed) - hovedpine - føler sig syg (kvalme) - opkastning - mavesmerter - løs afføring (diarré) - leverbetændelse (hepatitis) - udmattelse - feber - leverfunktionsprøver udenfor normalområdet
English: It is not recommended to coadminister ketoconazole and Viramune (see section 4.4).
Danish: Det anbefales ikke at coadministrer ketoconazol og Viramune (se pkt.
English: Viramune may be taken with or without food.
Danish: Viramune kan tages med eller uden mad.
English: Approximately half of the patients had at least 3 years of prior exposure to Viramune immediate-release prior to entering study
Danish: Cirka halvdelen af patienterne havde mindst 3 års forudgående behandling med Viramune 200 mg, før inkludering i studie 1100.1526.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/97/055/008 [30 prolonged-release]
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/97/055/008 [30 depottabletter]
English: Viramune belongs to a group of medicines called antiretrovirals, used in the treatment of Human Immunodeficiency Virus (HIV-1) infection.
Danish: Viramune tilhører en gruppe af lægemidler, som kaldes antiretrovirale lægemidler.
English: Saquinavir/ritonavir and Viramune can be co-administered without dose adjustments.
Danish: Saquinavir/ritonavir og Viramune kan co-administreres uden dosisjustering.
English: This medicine contains less than 1 mmol sodium (23 mg) per dosage unit, that is to say essentially ‘sodium-free'.
Danish: Dette lægemiddel indeholder mindre end 1 mmol (23 mg) natrium pr. dosisenhed, dvs. det er i det væsentlige natrium-frit.
English: Cross resistance to delavirdine and efavirenz is expected after virologic failure with nevirapine.
Danish: I tilfælde af virologisk svigt ved nevirapin-behandling kan der efterfølgende forventes krydsresistens til delavidin og efavirenz.
English: Nevirapine in combination with efavirenz exhibited a strong antagonistic anti-HIV-1 activity in vitro (see section 4.5) and was additive to antagonistic with the protease inhibitor ritonavir or the fusion inhibitor enfuvirtide.
Danish: Nevirapin viste in vitro i kombination med efavirenz en stærk antagonistisk anti-hiv-1-aktivitet (se pkt.
English: General disorders and administration site conditions Common fatigue
Danish: Almene symptomer og reaktioner på administrationsstedet Almindelig:
English: Rifampicin 600 mg QD
Danish: Rifampicin 600 mg 4 gange daglig
English: - if you have taken Viramune before and had to stop the treatment because you suffered from: - severe skin rash - skin rash with other symptoms for example: - fever
Danish: hvis du tidligere har taget Viramune og måtte stoppe behandlingen, fordi du har fået: alvorligt hududslæt hududslæt og samtidig har andre symptomer som - feber - blæredannelse
English: Gastrointestinal disorders Common abdominal pain, nausea, diarrhoea Uncommon vomiting
Danish: Abdominalsmerter, kvalme, diarré
English: An increase in weight and in levels of blood lipids and glucose may occur during antiretroviral therapy.
Danish: Vægt og metaboliske parametre: Vægtstigning og forhøjede lipider og glucose i blodet kan forekomme under antiretroviral behandling.
English: If you have any rash during this period, do not start taking Viramune prolonged-release tablets but consult your doctor.
Danish: Hvis du får nogen form for udslæt i denne periode, må du ikke begynde at tage Viramune depottabletter.
English: Do not use this medicine after the expiry date which is stated on the carton and on the blister after “EXP”.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på æsken og på blisteren efter ”EXP”.
English: Due to the metabolic pathway of raltegravir no interaction is expected.
Danish: Der forventes ingen interaktion på grund af mekanisme ved raltegravir metabolisme.
English: INFORMATION IN BRAILLE viramune 400 mg prolonged-release tablets
Danish: INFORMATION I BRAILLESKRIFT viramune 400 mg depottabletter
English: It is particularly important that you tell your doctor if you are taking or have recently taken: - St. John's Wort (Hypericum perforatum, medicine to treat depression) - rifampicin (medicine to treat tuberculosis) - rifabutin (medicine to treat tuberculosis) - macrolides e.g. clarithromycin (medicine to treat bacterial infections) - fluconazole (medicine to treat fungal infections) - ketoconazole (medicine to treat fungal infections) - itraconazole (medicine to treat fungal infections) - methadone (medicine used for treatment of opiate addicts) - warfarin (medicine to reduce blood clotting) - hormonal contraceptives (e.g. the “pill”) - atazanavir (another medicine to treat HIV-infection) - lopinavir/ritonavir (another medicine to treat HIV-infection) - fosamprenavir (another medicine to treat HIV-infection) - efavirenz (another medicine to treat HIV-infection) - etravirine (another medicine to treat HIV-infection) - rilpivirine (another medicine to treat HIV-infection) - delavirdine (another medicine to treat HIV-infection) - zidovudine (another medicine to treat HIV-infection) - boceprevir (medicine to treat hepatitis C) - telaprevir (medicine to treat hepatitis C) - elvitegravir/cobicistat (another medicine to treat HIV-infection)
Danish: Det er særligt vigtigt, at du fortæller det til din læge, hvis du tager eller for nylig har taget: - perikon (Hypericum perforatum, naturlægemiddel til behandling af depression) - rifampicin (mod tuberkulose) - rifabutin (mod tuberkulose) - makrolider som clarithromycin (antibiotika) - fluconazol (mod svampeinfektion) - ketoconazol (mod svampeinfektion) - itraconazol (mod svampeinfektion) - metadon (substitut for heroin eller andre opiater) - warfarin (antikoagulant-blodfortyndende) - hormonale antikonceptionsmidler, f.eks. p-piller - atazanavir (mod hiv-infektion) - lopinavir/ritonavir (mod hiv-infektion) - fosamprenavir (mod hiv-infektion) - efavirenz (mod hiv-infektion) - etravirin (mod hiv-infektion) - rilpivirin (mod hiv-infektion) - delavirdin (mod hiv-infektion) - zidovudin (mod hiv-infektion) - boceprevir (mod hepatitis C) - telaprevir (mod hepatitis C) - elvitegravir/cobicistat (mod hiv-infektion)
English: 55216 Ingelheim am Rhein, Germany
Danish: D-55216 Ingelheim am Rhein, Tyskland
English: Cases of hepatitis (severe and life-threatening hepatotoxicity, including fatal fulminant hepatitis) have been reported in patients treated with nevirapine.
Danish: Tilfælde af hepatitis (alvorlig og livstruende hepatotoksicitet, inkl.
English: The patients studied were receiving antiretroviral therapy containing Viramune 200 mg immediaterelease tablets twice daily for at least 6 weeks prior to pharmacokinetic sampling, with a median duration of therapy of 3.4 years.
Danish: De var som minimum behandlet med 200 mg Viramune tabletter med øjeblikkelig virkning 2 gange dagligt i 6 uger inden de farmakokinetiske prøver blev taget.
English: Metabolite 14-OH clarithromycin AUC  1.42 (1.16-1.73) Metabolite 14-OH clarithromycin Cmin  0 (0.68-1.49) Metabolite 14-OH clarithromycin Cmax  1.47 (1.21-1.80)
Danish: Metabolit 14-OH clarithromycin AUC Metabolit 14-OH clarithromycin Cmin Metabolit 14-OH clarithromycin Cmax
English: Blood and lymphatic system disorders Uncommon granulocytopenia Rare anaemia
Danish: Blod og lymfesystem Ikke almindelig :
English: If you stop taking Viramune for more than 7 days your doctor will instruct you to start the 14 day 'lead-in' period with Viramune oral suspension (described above) once again, before returning to the once daily dose with Viramune prolonged-release tablets.
Danish: Hvis du afbryder behandlingen med Viramune i mere end 7 dage, vil din læge råde dig til at starte igen med en 14 dages "optrapningsfase" med Viramune oral suspension (som beskrevet ovenfor), før du igen starter på behandling med Viramune depottabletter én gang dagligt.
English: 31.3 to 43.7
Danish: 4.4 og 4.5).
English: NAME OF THE MEDICINAL PRODUCT Viramune 200 mg tablets nevirapine
Danish: LÆGEMIDLETS NAVN Viramune 200 mg tabletter nevirapin
English: Viramune and abacavir may be coadministered without dose adjustments.
Danish: Viramune og abacavir kan coadministreres uden dosisjustering.
English: Viramune prolonged-release tablets can be taken with or without food.
Danish: Viramune depottabletter kan tages sammen med eller uden mad.
English: The following adverse reactions which may be causally related to the administration of Viramune prolonged-release tablets have been reported.
Danish: Følgende bivirkninger, som kan være forårsaget af Viramune depottabletter, er tidligere blevet rapporteret.
English: In study 1100.1486 (VERxVE) antiretroviral-naïve patients received a lead-in dose of Viramune 200 mg immediate-release once daily for 14 days (n=1068) and then were randomised to receive either Viramune 200 mg immediate-release twice daily or Viramune 400 mg prolonged-release once daily.
Danish: I studie 1100.1486 (VERxVE) med antiretroviralnaive patienter var optrapningsdosis af Viramune 200 mg én gang dagligt i 14 dage (n=1068), hvorefter patienterne blev randomiseret til enten Viramune 200 mg tabletter to gange dagligt eller Viramune 400 mg i depotform én gang dagligt.
English: Female gender and higher CD4 counts (>250/mm
Danish: Kvindelige patienter og patienter med høje CD4-celletal (> 250 celler/mm
English: Nevirapine AUC  1.25 (1.17-1.34) Nevirapine Cmin  1.32 (1.22-1.43) Nevirapine Cmax  1.17 (1.09-1.25)
Danish: Nevirapin AUC  1,25 (1,17-1,34) Nevirapin Cmin  1,32 (1,22-1,43) Nevirapin Cmax  1,17 (1,09-1,25)
English: If ASAT and ALAT return to baseline values and if the patient had no clinical signs or symptoms of hepatitis, rash, constitutional symptoms or other findings suggestive of organ dysfunction, it may be possible to reintroduce nevirapine, on a case by case basis, at the starting dose regimen of Viramune immediate-release once daily for 14 days followed by Viramune prolonged-release tablets once daily.
Danish: Hvis ASAT og ALAT vender tilbage til baselineværdier, og hvis patienten ikke har nogen kliniske tegn eller symptomer på hepatitis, udslæt eller andre symptomer eller fund, der tyder på organpåvirkning, er det muligt at genintroducere nevirapin efter en individuel patientvurdering, med en startdosis én gang dagligt i 14 dage af Viramune med umiddelbar frigivelse efterfulgt af Viramune depottabletter én gang dagligt.
English: Lamivudine 150 mg BID
Danish: Lamivudin 150 mg 2 gange daglig
English: Viramune contains lactose
Danish: Viramune indeholder lactose
English: These adverse reactions are commonly associated with other antiretroviral agents and may be expected to occur when nevirapine is used in combination with other agents; however it is unlikely that these adverse reactions are due to nevirapine treatment.
Danish: Disse bivirkninger er ofte forbundet med andre antiretrovirale midler og vil muligvis forventes at opstå, når nevirapin anvendes i kombination med disse midler.
English: If ASAT and ALAT return to baseline values and if the patient had no clinical signs or symptoms of hepatitis, rash, constitutional symptoms or other findings suggestive of organ dysfunction, it may be possible to reintroduce nevirapine, on a case by case basis, at the starting dose regimen of 200 mg/day for 14 days followed by 400 mg/day.
Danish: Hvis ASAT og ALAT vender tilbage til baselineværdier, og hvis patienten ikke har nogen kliniske tegn eller symptomer på hepatitis, udslæt eller andre symptomer eller fund, der tyder på organpåvirkning, er det muligt at genintroducere nevirapin efter en individuel patientvurdering med en startdosis på 200 mg/dag i 14 dage efterfulgt af 400 mg/dag.
English: If you stop taking Viramune for more than 7 days your doctor will instruct you to start the 14 day 'lead-in' period with Viramune tablets (described above) once again, before returning to the once daily dose with Viramune prolonged-release tablets.
Danish: Hvis du afbryder behandlingen med Viramune i mere end 7 dage, vil din læge råde dig til at starte igen med en 14 dages "optrapningsfase" med Viramune tabletter (som beskrevet ovenfor), før du igen starter på behandling med Viramune depottabletter én gang dagligt.
English: If patients experience fatigue they should avoid potentially hazardous tasks such as driving or operating machinery.
Danish: Hvis patienter oplever træthed, skal de afstå fra at køre bil eller betjene maskiner.
English: Weight Range (kg) for patients  8 years of age on a body weight basis receiving 4 mg/kg.
Danish: Vægtinterval (kg) for patienter ≥ 8 år med dosis beregnet efter legemsvægt.
English: Uncommon liver function test abnormal (alanine aminotransferase increased; transaminases increased; aspartate aminotransferase increased; gamma-glutamyltransferase increased; hepatic enzyme increased; hypertransaminasaemia), blood phosphorus decreased, blood pressure increased
Danish: Leverfunktionstest uden for normalområdet (forhøjet alaninaminotransferase, forhøjede transaminaser, forhøjet aspartat-aminotransferase, forhøjet gamma-glutamyltransferase, forhøjet hepatisk enzym, hypertransaminasæmi), nedsat fosfor i blodet, øget blodtryk
English: Didanosine and Viramune can be coadministered without dose adjustments.
Danish: Didanosin og Viramune kan coadministreres uden dosisjustering.
English: It is not recommended to coadminister rifampicin and Viramune (see section 4.4).
Danish: Det anbefales ikke at coadministrer rifampicin og Viramune (se pkt.
English: In a 200 mg nevirapine single dose pharmacokinetic study of HIV-negative patients with mild and moderate hepatic impairment (Child-Pugh A, n=6; Child-Pugh B, n=4), a significant increase in the AUC of nevirapine was observed in one Child-Pugh B patient with ascites suggesting that patients with worsening hepatic function and ascites may be at risk of accumulating nevirapine in the systemic circulation.
Danish: I et 200 mg nevirapine enkelt dosis farmakokinetisk studie af hiv-negative patienter med mild til moderat hepatisk dysfunktion (Child-pugh A, n=6; Child-pugh B, n=4), blev der observeret en signifikant forøgelse af nevirapine-AUC hos en Child-pugh B patient med ascites.
English: It is not recommended to coadminister efavirenz and Viramune (see section 4.4), because of additive toxicity and no benefit in terms of efficacy over either NNRTI alone (for results of 2NN study, see section 5.1 Viramune immediate-release formulations).
Danish: 4.4) på grund af additiv toksicitet og ingen fordel med hensyn til virkning i forhold til det enkelte NNRTI alene (for resultaterne fra 2NN-studiet, se pkt.