FrancophonIA/ELRC3.0 huggingface dataset:
English: Other medicines and Voriconazole Hikma
Slovenian: Druga zdravila in zdravilo Vorikonazol Hikma
English: and Fusarium spp.
Slovenian: in Fusarium spp.
English: Voriconazole Hikma must not be diluted with 4.2 % Sodium Bicarbonate Infusion.
Slovenian: Zdravila Vorikonazol Hikma se ne sme redčiti z infuzijo 4,2 % natrijevega bikarbonata.
English: Total parenteral nutrition (TPN) need not be discontinued when prescribed with Voriconazole Hikma, but does need to be infused through a separate line.
Slovenian: Pri predpisanem zdravilu Vorikoanzol Hikma ni potrebno prekiniti dajanja popolne parenteralne prehrane (TPN - total parenteral nutrition), vendar mora biti le-ta infundirana skozi ločeno linijo.
English: Dose reduction of sulfonylureas should be considered.
Slovenian: Razmisliti je treba o prilagoditvi odmerka sulfonilsečnin.
English: 12 weeks after EOT
Slovenian: 12 tednov po KT
English: 9 Includes dyspnoea and dyspnoea exertional.
Slovenian: 9 Vključuje dispnejo in dispnejo med naporom.
English: Voriconazole should be administered primarily to patients with progressive, possibly life-threatening infections.
Slovenian: Vorikonazol je namenjen predvsem uporabi pri bolnikih z napredujočimi, potencialno smrtno nevarnimi okužbami.
English: Co-administration of voriconazole and sirolimus is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba vorikonazola in sirolimusa je kontraindicirana (glejte poglavje 4.3).
English: In an overdose, haemodialysis may assist in the removal of voriconazole and SBECD from the body.
Slovenian: V primeru prevelikega odmerjanja se lahko presežki vorikonazola in SBECD iz telesa odstranijo s hemodializo.
English: Squamous cell carcinoma of the skin has been reported in patients, some of whom have reported prior phototoxic reactions.
Slovenian: Pri bolnikih, med katerimi so nekateri v preteklosti poročali o fototoksičnih reakcijah, so poročali o ploščatoceličnemu karcinomu kože.
English: In clinical trials, visual impairments (including blurred vision, photophobia, chloropsia, chromatopsia, colour blindness, cyanopsia, eye disorder, halo vision, night blindness, oscillopsia, photopsia, scintillating scotoma, visual acuity reduced, visual brightness, visual field defect, vitreous floaters, and xanthopsia) with voriconazole were very common.
Slovenian: V kliničnih preskušanjih so bile okvare vida (vključno z zamegljenim vidom, fotofobijo, kloropsijo, kromatopsijo, barvno slepoto, cianopsijo, okvaro vida, videnjem svetlobnih krogov (halo), nočno slepoto, oscilopsijo, fotopsijo, teihopsijo, zmanjšano ostrino vida, občutkom svetlosti pri gledanju, izpadom vidnega polja, delci v steklovini in ksantopsijo) pri uporabi vorikonazola zelo pogoste.
English: Efavirenz may be co-administered with voriconazole if the maintenance dose of voriconazole is increased to 400 mg every 12 hours and the efavirenz dose is reduced by 50%, i.e. to 300 mg once daily.
Slovenian: Efavirenz se lahko uporablja sočasno z vorikonazolom, če se vzdrževalni odmerek vorikonazola poveča na 400 mg vsakih 12 ur, odmerek efavirenza pa zmanjša za 50 %, tj. na 300 mg enkrat na dan.
English: Studies conducted in Caucasian and Japanese healthy subjects have shown that poor metabolisers have, on average, 4-fold higher voriconazole exposure (AUCτ) than their homozygous extensive metaboliser counterparts.
Slovenian: Študije pri zdravih preskušancih bele rase in preskušancih z Japonske so pokazale, da je izpostavljenost vorikonazolu (AUC τ) pri osebah z zmanjšano presnovo v povprečju 4-krat večja kot pri primerljivih homozigotnih osebah z izrazito presnovo.
English: If you are already being treated with phenytoin, your blood concentration of phenytoin will need to be monitored during your treatment with Voriconazole Hikma and your dose may be adjusted.
Slovenian: Če se že zdravite s fenitoinom, je treba med zdravljenjem z zdravilom Vorikonazol Hikma nadzirati koncentracijo fenitoina v krvi in morda prilagoditi odmerek.
English: Voriconazole has been associated with QTc interval prolongation.
Slovenian: Srce in ožilje Vorikonazol je bil povezan s podaljšanjem intervala QTc.
English: It is recommended that a standard 20 ml (non-automated) syringe be used to ensure that the exact amount (19.0 ml) of water for injections or sodium chloride 9 mg/ml (0.9%) solution for injection is dispensed.
Slovenian: Priporočljivo je, da uporabite standardno 20 ml (neavtomatsko) brizgo, da boste lahko zagotovili, da bo dodana natančna količina (19.0 ml) vode za injekcije ali 9 mg/ml (0.9%) raztopine natrijevega klorida za infundiranje.
English: Efavirenz Cmax ↑ 38% Efavirenz AUCτ ↑ 44% Voriconazole Cmax ↓ 61% Voriconazole AUCτ ↓ 77%
Slovenian: efavirenz Cmax ↑ 38% efavirenz AUCτ ↑ 44% vorikonazol Cmax ↓ 61% vorikonazol AUCτ ↓ 77%
English: If infused through a multiple-lumen catheter, TPN needs to be administered using a different port from the one used for Voriconazole Hikma.
Slovenian: Pri infuziji skozi multi-lumni kateter je treba pri dajanju TPN uporabiti drugo odprtino kot za zdravilo Vorikonazol Hikma.
English: Metabolism and nutrition disorders oedema peripheral hypoglycaemia, hypokalaemia, hyponatraemia
Slovenian: Presnovne in prehranske motnje periferni edem hipoglikemija, hipokaliemija, hiponatriemija
English: No dose adjustment of voriconazole is recommended.
Slovenian: Prilagoditev odmerka vorikonazola ni priporočljiva.
English: • Enlarged lymph glands (sometimes painful), , failure of blood marrow, (increased eosinophil)
Slovenian: • povečane bezgavke (včasih boleče), odpoved kostnega mozga, povečano število eozinofilcev
English: Phenytoin (CYP2C9 substrate and potent CYP450 inducer) Careful monitoring of phenytoin levels is recommended when phenytoin is co-administered with voriconazole.
Slovenian: Fenitoin (substrat CYP2C9 in močan induktor CYP450) Med sočasno uporabo fenitoina in vorikonazola je priporočljivo natančno nadziranje koncentracije fenitoina.
English: • Allergic skin reactions (sometimes severe), including life-threatening skin condition that causes painful blisters and sores of the skin and mucous membranes, especially in the mouth inflammation of the skin hives, sunburn or severe skin reaction following exposure to light or sun,
Slovenian: • alergijske kožne reakcije (včasih hude), vključno s smrtno nevarnim kožnim stanjem, ki povzroča boleče mehurje in rane na koži ter sluznicah (zlasti v ustih), vnetje kože, , koprivnica, sončne opekline ali hude kožne reakcije po izpostavljanju svetlobi ali soncu, rdečica in draženje kože, rdeče ali vijoličasto obarvanje kože, ki ga lahko povzroči nizko število krvnih ploščic, ekcem
English: Reactions during the infusion have occurred uncommonly with Voriconazole Hikma (including flushing, fever, sweating, increased heart rate and shortness of breath).
Slovenian: Občasno so se med infundiranjem zdravila Vorikonazol Hikma pojavile reakcije (vključno z zardevanjem, povišano telesno temperaturo, znojenjem, pospešenim srčnim utripom in kratko sapo).
English: The maintenance dose of voriconazole may be increased to 5 mg/kg intravenously BID or from 200 mg to 350 mg orally BID (100 mg to 200 mg orally BID in patients less than 40 kg) (see section 4.2).
Slovenian: Vzdrževalni odmerek vorikonazola se lahko poveča na 5 mg/kg intravensko BID ali z 200 mg na 350 mg peroralno BID (s 100 mg na 200 mg peroralno BID pri bolnikih, lažjih od 40 kg) (glejte poglavje 4.2).
English: Non-infectious periostitis with elevated fluoride and alkaline phosphatase levels has been reported in transplant patients.
Slovenian: Pri bolnikih s presadkom so poročali o neinfektivnem periostitisu, ki ga spremlja zvišanje ravni fluorida in alkalne fosfataze.
English: Ritonavir Cmax ↓ 25% Ritonavir AUCτ ↓13% Voriconazole Cmax ↓ 24% Voriconazole AUCτ ↓ 39%
Slovenian: ritonavir Cmax ↓ 25% ritonavir AUCτ ↓13% vorikonazol Cmax ↓ 24% vorikonazol AUCτ ↓ 39%
English: Dosage adjustments in case of co-administration
Slovenian: Prilagajanje odmerka pri sočasni uporabi
English: Voriconazole Hikma is intended for patients with worsening, possibly life-threatening, fungal infections.
Slovenian: Zdravilo Vorikonazol Hikma je namenjeno bolnikom, pri katerih se glivična okužba poslabšuje in je morda smrtno nevarna.
English: The predicted total exposures in children following IV maintenance doses of 4 and 8 mg/kg twice daily were comparable to those in adults following 3 and 4 mg/kg IV twice daily, respectively.
Slovenian: Pričakovane celokupne izpostavljenosti pri otrocih po uporabi intravenskih vzdrževalnih odmerkov, 4 mg/kg oziroma 8 mg/kg dvakrat na dan, so bile primerljive s tistimi pri odraslih pouporabi 3 mg/kg oziroma 4 mg/kg intravensko dvakrat na dan.
English: Long term exposure to voriconazole greater than 180 days (6 months) requires careful assessment of the benefit-risk balance (see sections 4.4 and 5.1).
Slovenian: Pri dolgotrajni izpostavljenosti vorikonazolu, daljši od 180 dni (6 mesecev), je treba natančno oceniti razmerje med koristmi in tveganji (glejte poglavji 4.4 in 5.1).
English: • Enlarged liver, liver failure, gallbladder disease, gallstones
Slovenian: • povečana jetra, odpoved jeter, bolezni žolčnika, žolčni kamni
English: Vascular disorders hypotension, phlebitis thrombophlebitis, lymphangitis
Slovenian: Žilne bolezni hipotenzija, flebitis tromboflebitis, limfangitis
English: Specimens for fungal culture and other relevant laboratory studies (serology, histopathology) should be obtained prior to therapy to isolate and identify causative organisms.
Slovenian: Za osamitev in prepoznavo povzročiteljev je treba vzorce za mikološko kulturo in druge relevantne laboratorijske študije (serologija, histopatologija) odvzeti pred zdravljenjem.
English: An impurity, present in SBECD, has been shown to be an alkylating mutagenic agent with evidence for carcinogenicity in rodents.
Slovenian: Dokazano je, da je nečistoča v SBECD alkilirajoča mutagena snov, karcinogena pri glodalcih.
English: Gastrointestin al disorders diarrhoea, vomiting, abdominal pain, nausea cheilitis, dyspepsia, constipation, gingivitis peritonitis, pancreatitis, swollen tongue, duodenitis, gastroenteritis, glossitis
Slovenian: Bolezni prebavil diareja, bruhanje, bolečine v trebuhu, navzea heilitis, dispepsija, zaprtje, gingivitis peritonitis, pankreatitis, otekel jezik, duodenitis, gastroenteritis, glositis
English: Co-administration with rifampicin, carbamazepine and phenobarbital since these medicinal products are likely to decrease plasma voriconazole concentrations significantly (see section 4.5).
Slovenian: Sočasna uporaba z rifampicinom, karbamazepinom in fenobarbitalom, ker lahko ta zdravila pomembno zmanjšajo koncentracije vorikonazola v plazmi (glejte poglavje 4.5).
English: Uncommon ≥ 1/1,000 to <
Slovenian: Občasni ≥ 1/1.000 do < 1/100
English: When voriconazole is discontinued, ciclosporin levels must be carefully monitored and the dose increased as necessary.
Slovenian: Po koncu uporabe vorikonazola je treba koncentracijo ciklosporina natančno nadzirati in njegov odmerek povečati, kot je potrebno.
English: 8 mg/kg twice a day
Slovenian: 8 mg/kg dvakrat na dan
English: Concomitant use of voriconazole and rifabutin should be avoided unless the benefit outweighs the risk.
Slovenian: Sočasni uporabi vorikonazola in rifabutina se je treba izogniti, razen če korist odtehta tveganje.
English: General disorders and administration site conditions pyrexia chest pain, face oedema11, asthenia, chills infusion site reaction, influenza like illness
Slovenian: Splošne težave in spremembe na mestu aplikacije pireksija bolečine v prsnem košu, edem obraza11, astenija, mrzlica reakcija na mestu infundiranja, gripi podobna bolezen
English: When Voriconazole Hikma treatment is stopped by your doctor you should not experience any effects.
Slovenian: Ko bo zdravnik končal zdravljenje z zdravilom Vorikonazol Hikma , ne bi smeli občutiti nobenih posledic.
English: Mycophenolic acid (1 g single dose) [UDP-glucuronyl transferase substrate]
Slovenian: mikofenolna kislina (enkratni 1 g odmerek) [substrat UDPglukuroniltransferaze]
English: Ritonavir Cmax and AUCτ ↔ Voriconazole Cmax ↓ 66% Voriconazole AUCτ ↓ 82%
Slovenian: ritonavir Cmax and AUCτ ↔ vorikonazol Cmax ↓ 66% vorikonazol AUCτ ↓ 82%
English: Inflammation of the kidney, proteins in the urine, damage to the kidney
Slovenian: • vnetje ledvic, beljakovine v urinu, poškodbe ledvic
English: 9 mg/kg every 12 hours for the first 24 hours
Slovenian: 9 mg/kg vsakih 12 ur v prvih 24 urah
English: 9 mg/kg every 12 hours
Slovenian: 9 mg/kg vsakih 12 ur
English: Voriconazole Hikma is a single dose unpreserved sterile lyophile.
Slovenian: Zdravilo Vorikonazol Hikma je en odmerek sterilnega liofilizata brez konzervansov.
English: • Flu-like symptoms, irritation and inflammation of the gastrointestinal tract, inflammation of the gastrointestinal tract causing antibiotic associated diarrhoea, inflammation of the lymphatic vessels
Slovenian: • gripi podobni simptomi, draženje in vnetje prebavil, vnetje prebavil, ki povzroča drisko, povezano z uporabo antibiotikov, vnetje limfnih žil
English: • Visual impairment (change in vision including blurred vision, visual color alterations, abnormal intolerance to visual perception of light, colour blindness, eye disorder, halo vision, night blindness,
Slovenian: • okvare vida (spremembe vida, vključno z zamegljenim vidom, spremembami zaznavanja barv, nenormalno občutljivostjo pri vidnem zaznavanju svetlobe, barvno slepoto, okvaro vida, videnjem svetlobnih krogov (halo), nočno slepoto, nihajočim vidom, videnjem iskrenja, avro z vidnimi pojavi, zmanjšano ostrino vida, občutkom svetlosti pri gledanju, izpadom običajnega vidnega polja, pikami v vidnem polju)
English: Voriconazole has been associated with cases of serious hepatic toxicity in patients with other serious underlying conditions.
Slovenian: Vorikonazol je bil pri bolnikih z drugimi hudimi že obstoječimi boleznimi povezan s hudimi hepatotoksičnimi učinki.
English: Dose reduction of statins should be considered.
Slovenian: Razmisliti je treba o prilagoditvi odmerka statinov.
English: Fluconazole (200 mg QD) [CYP2C9, CYP2C19 and CYP3A4 inhibitor]
Slovenian: flukonazol (200 mg QD) [zaviralec CYP2C9, CYP2C19 in CYP3A4]
English: When voriconazole is discontinued, tacrolimus levels must be carefully monitored and the dose increased as necessary.
Slovenian: Po koncu uporabe vorikonazola je treba koncentracijo takrolimusa natančno nadzirati in njegov odmerek povečati, kot je potrebno.
English: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), which can be life-threatening or fatal, have been reported with the use of voriconazole.
Slovenian: Pri uporabi vorikonazola so poročali o hudih kožnih neželenih učinkih (SCAR - Severe Cutaneous Adverse Reactions), kot so na primer Stevens-Johnsonov sindrom (SJS), toksična epidermalna nekroliza (TEN) ter reakcija na zdravilo z eozinofilijo in sistemskimi simptomi (DRESS - Drug Reaction with Eosinophilia and Systemic Symptoms), ki so lahko življenjsko nevarni ali smrtni.
English: If a patient develops skeletal pain and radiologic findings compatible with periostitis VORICONAZOLE HIKMA discontinuation should be considered after multidisciplinary advice.
Slovenian: Če se pri bolniku pojavi bolečina v skeletu in rezultati radiološke preiskave nakazujejo na periostitis, je treba po obravnavati s strani več zdravnikov specialistov razmisliti o prekinitvi zdravljenja z zdravilom VORIKONAZOL HIKMA.
English: *ADR identified post-marketing
Slovenian: * neželeni učinki, odkriti v obdobju trženja
English: Voriconazole Cmax ↑ 18% Voriconazole AUCτ ↑ 23%
Slovenian: vorikonazol Cmax ↑ 18% vorikonazol AUCτ ↑ 23%
English: Patients have developed severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) (uncommon), toxic epidermal necrolysis (TEN) (rare), drug reaction with eosinophilia and systemic symptoms (DRESS) (rare) and erythema multiforme (rare) during treatment with voriconazole (see section 4.4).
Slovenian: Večina izpuščajev je bila blagih do zmerno izrazitih Pri bolnikih so se med zdravljenjem z vorikonazolom pojavili hudi kožni neželeni učinki (SCAR), vključno s Stevens-Johnsonovim sindromom (SJS) (občasno), toksično epidermalno nekrolizo (TEN) (redko) reakcijo na zdravilo z eozinofilijo in sistemskimi simptomi (DRESS) (redko) in multiformnim eritemom (redko) (glejte poglavje 4.4).
English: Voriconazole Hikma is an antifungal medicine.
Slovenian: Zdravilo Vorikonazol Hikma je protiglivično zdravilo.
English: Omeprazole (40 mg QD)* [CYP2C19 inhibitor; CYP2C19 and CYP3A4 substrate]
Slovenian: omeprazol (40 mg QD)* [inhibitor CYP2C19; substrat CYP2C19 in CYP3A4]
English: During infusion of the intravenous formulation of voriconazole in healthy subjects, anaphylactoid-type reactions, including flushing, fever, sweating, tachycardia, chest tightness, dyspnoea, faintness, nausea, pruritus and rash have occurred.
Slovenian: Med infundiranjem intravenskega pripravka vorikonazola zdravim preskušancem so se pojavile anafilaktoidne reakcije, vključno z zardevanjem, zvišano telesno temperaturo, znojenjem, tahikardijo, tiščanjem v prsnem košu, dispnejo, omedlevico, navzeo, srbenjem in izpuščajem.
English: 6 weeks after EOT
Slovenian: 6 tednov po KT
English: Digoxin Cmax ↔ Digoxin AUCτ ↔
Slovenian: digoksin Cmax ↔ digoksin AUCτ ↔
English: Eye disorders visual impairment6
Slovenian: Očesne bolezni okvare vida6
English: Co-administration with St John's Wort (see section 4.5).
Slovenian: Sočasna uporaba s šentjanževko (glejte poglavje 4.5).
English: In reproduction studies, voriconazole was shown to be teratogenic in rats and embryotoxic in rabbits at systemic exposures equal to those obtained in humans with therapeutic doses.
Slovenian: V reprodukcijskih študijah je bilo dokazano, da je vorikonazol ob sistemski izpostavljenosti, kakršna je pri ljudeh dosežena s terapevtskimi odmerki, pri podganah teratogen in pri kuncih embriotoksičen.
English: If patients develop a rash they should be monitored closely and Voriconazole Hikma discontinued if lesions progress.
Slovenian: Če se bolniku pojavi izpuščaj, ga je treba skrbno spremljati in jemanje zdravila VORIKONAZOL HIKMA prekiniti, če lezije napredujejo.
English: The most commonly reported adverse reactions were visual impairment, pyrexia, rash, vomiting, nausea, diarrhoea, headache, peripheral oedema liver function test abnormal, respiratory distress and abdominal pain.
Slovenian: Najpogosteje opisani neželeni učinki so bili okvare vida, pireksija, izpuščaj, bruhanje, navzea, diareja, glavobol, periferni edemi, nenormalni izvidi testov jetrne funkcije, dihalna stiska in bolečine v trebuhu.
English: Required Volumes of 10 mg/ml Voriconazole Hikma Concentrate
Slovenian: Volumni, potrebni za 10 mg/ml koncentrata zdravila Vorikonazol Hikma
English: Oral Contraceptives*
Slovenian: intravensko peroralno*
English: SPECIAL STORAGE CONDITIONS Store in the original package in order to protect from light.
Slovenian: DATUM IZTEKA ROKA UPORABNOSTI ZDRAVILA Uporabno do: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte v originalni ovojnini za zagotovitev zaščite pred svetlobo.
English: • Loss of most fibers in the optic nerve clouding of the cornea, involuntary movement of the eye
Slovenian: • izguba večine vlaken vidnega živca, zamotnitev roženice, nehotni gibi očesa
English: 4 mg/kg twice a day
Slovenian: 4 mg/kg dvakrat na dan
English: It may only be continued up to 180 days after transplantation in case of continuing immunosuppression or graft versus host disease (GvHD) (see section
Slovenian: Pri neprekinjeni imunosupresiji ali bolezni presadka proti prejemniku (GVHD - Graft Versus Host Disease) lahko traja največ 180 dni po transplantaciji (glejte poglavje 5.1).
English: Voriconazole may be coadministered with efavirenz if the voriconazole maintenance dose is increased to 400 mg BID and the efavirenz dose is decreased to 300 mg QD.
Slovenian: Vorikonazol lahko uporabljamo sočasno z efavirenzom, če odmerek vorikonazola zvečamo na 400 mg BID in odmerek efavirenza zmanjšamo na 300 mg QD.
English: Dose reduction of vinca alkaloids should be considered.
Slovenian: Razmisliti je treba o zmanjšanju odmerka alkaloidov rožnatega zimzelena.
English: Statins (e.g., lovastatin) [CYP3A4 substrates]
Slovenian: statini (kot je lovastatin) [substrati CYP3A4 ]
English: 2 weeks after EOT
Slovenian: 2 tedna po KT
English: Careful monitoring for any occurrence of drug toxicity and/or lack of efficacy, and dose adjustment may be needed.
Slovenian: Bolnike je treba natančno nadzorovati glede pojava kakršnihkoli toksičnih učinkov zdravila in/ali izgube učinkovitosti.
English: Voriconazole Hikma requires reconstitution and dilution (see section 6.6) prior to administration as an intravenous infusion.
Slovenian: Zdravilo Vorikonazol Hikma je treba pred aplikacijo v obliki intravenske infuzije rekonstituirati in redčiti (glejte poglavje 6. 6).
English: In an independent published study, Oxycodone Cmax ↑ 1.7-fold Oxycodone AUC0-∞ ↑ 3.6-fold
Slovenian: v neodvisni objavljeni študiji, oksikodon Cmax ↑ 1,7-krat oksikodon AUC0-∞ ↑ 3,6-krat
English: Voriconazole (N=248)
Slovenian: Časovna točka vorikonazol (N=248)
English: Myeloablative conditioning regimens
Slovenian: Mieloablativni režim
English: Astemizole, cisapride, pimozide, quinidine and terfenadine [CYP3A4 substrates]
Slovenian: Priporočila glede sočasne uporabe astemizol, cisaprid, pimozid, kinidin in terfenadin [substrati CYP3A4]
English: Although not studied, voriconazole is likely to significantly increase the plasma concentrations of everolimus.
Slovenian: Čeprav ni raziskano, lahko vorikonazol pomembno poveča koncentracijo everolimusa v plazmi.
English: • Squamous cell carcinoma of the skin (SCC)
Slovenian: • Ploščatocelični karcinom kože
English: Monitoring of renal function
Slovenian: Nadzor delovanja ledvic
English: The powder is reconstituted with either 19 ml of water for injections or 19 ml of sodium chloride 9 mg/ml (0.9%) solution for injection to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml of voriconazole.
Slovenian: Prašek rekonstituirajte bodisi z 19 ml vode za injekcije bodisi z 19 ml 9 mg/ml (0.9%) raztopine natrijevega klorida za infundiranje, s čimer boste dobili 20 ml ekstraktabilnega volumna bistrega koncentrata, ki vsebuje 10 mg/ml vorikonazola.
English: Voriconazole Hikma 200 mg powder for solution for infusion is for intravenous use only.
Slovenian: Zdravilo Vorikonazol Hikma 200 mg prašek za raztopino za infundiranje je samo za intravensko uporabo.
English: • Blood cholesterol increased, blood urea increased
Slovenian: • povišana raven holesterola v krvi, povišana raven sečnine v krvi
English: - The other ingredient is sulfobutylether beta cyclodextrin sodium.
Slovenian: - Druge sestavine zdravila: sulfobutileter betaciklodekstrin natrij
English: Voriconazole Hikma powder for solution for infusion needs to first be reconstituted with either 19 ml of water for injections or 19 ml of sodium chloride 9 mg/ml (0.9%) solution for injection to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml voriconazole.
Slovenian: Zdravilo Vorikonazol Hikma prašek za raztopino za infundiranje rekonstituirajte bodisi z 19 ml vode za injekcije bodisi z 19 ml 9 mg/ml (0.9%) raztopine natrijevega klorida za infundiranje, s čimer boste dobili 20 ml ekstraktabilnega volumna bistrega koncentrata, ki vsebuje 10 mg/ml vorikonazola.
English: Dose reduction in oxycodone and other long-acting opiates metabolized by CYP3A4 (e.g., hydrocodone) should be considered.
Slovenian: Razmisliti je treba o zmanjšanju odmerka oksikodona in drugih dolgodelujočih opiatov, ki se presnavljajo preko CYP3A4 (npr. hidrokodon).
English: Voriconazole was compared to itraconazole as primary prophylaxis in an open-label, comparative, multicenter study of adult and adolescent allogeneic HSCT recipients without prior proven or probable IFI.
Slovenian: V odprti primerjalni multicentrični študiji so primerjali vorikonazol in itrakonazol kot primarno profilakso pri odraslih in mladostnikih, ki so bili prejemniki homolognih HSCT brez predhodno dokazane ali verjetne IGO.