FrancophonIA/ELRC3.0 huggingface dataset:
English: • a low red blood cell count (anaemia) or low white blood cell count (neutropenia)
Slovenian: • zmanjšano število rdečih krvnih celic (anemija) ali zmanjšano število belih krvnih celic
English: Therefore, patients with any of these symptoms should be carefully evaluated for the presence of this hypersensitivity (see section 4.4).
Slovenian: Tako je potrebno bolnike s katerim koli od teh simptomov obravnavati resno in presoditi možnost preobčutljivostne reakcije (glejte poglavje 4.4).
English: Within this population, 104 patients, weighing at least 25 kg, received 600 mg abacavir and 300 mg lamivudine as Kivexa once daily, with a median duration of exposure of 596 days.
Slovenian: Znotraj te populacije so 104 bolniki, ki tehtajo vsaj 25 kg, prejeli 600 mg abakavirja in 300 mg lamivudina v obliki zdravila Kivexa enkrat na dan z mediano trajanja izpostavljenosti 596 dni.
English: Virologic Response at Week 48 ITT-Exposed Population < 50 copies/ml TLOVR
Slovenian: Virusni odziv po 48 tednih ITT-izpostavljene populacije z < 50 kopij/ml TLOVR
English: Abacavir has a weak potential to cause chromosomal damage both in vitro and in vivo at high tested concentrations.
Slovenian: Abakavir ima šibek potencial, da pri visokih testnih koncentracijah tako in vitro kot in vivo povzroča poškodbo kromosomov.
English: Common: Headache, insomnia.
Slovenian: Pogosti: glavobol, insomnija
English: Abacavir + lamivudine + NNRTI
Slovenian: Abakavir + lamivudin + NNRTI
English: • Emtricitabine, to treat HIV infection
Slovenian: • emtricitabin, za zdravljenje okužbe s HIV,
English: Lamivudine: AUC ↑40% Trimethoprim: AUC ↔ Sulfamethoxazole: AUC ↔ (organic cation transporter inhibition)
Slovenian: lamivudin: AUC ↑40% trimetoprim: AUC ↔ sulfametoksazol: AUC ↔ (zavrtje organskega kationskega prenašalca)
English: Baseline CD4 category >350 71/109 (65%)
Slovenian: Izhodiščna kategorija CD4 > 350 71/109 (65 %)
English: For the CNA109586 (ASSERT) and CNA30021 studies in treatment-naïve patients, genotype data was obtained for only a subset of patients at screening or at baseline, as well as for those patients who met virologic failure criteria.
Slovenian: V študijah CNA109586 (ASSERT) in CNA30021 pri še nezdravljenih (naivnih) bolnikih so genotipske podatke pridobili samo za podskupino bolnikov ob presejanju ali izhodiščno ter za bolnike, ki so izpolnjevali merila virološkega neuspeha.
English: The adverse reactions considered at least possibly related to abacavir or lamivudine are listed by body system, organ class and absolute frequency.
Slovenian: Neželeni učinki, za katere obstaja vsaj možna povezava z abakavirjem ali lamivudinom, so navedeni po organskih sistemih in absolutni pogostnosti.
English: • if they are overweight.
Slovenian: • če imajo prekomerno telesno maso.
English: Trimethoprim/sulfamethoxazole (Co-trimoxazole)/Lamivudine (160 mg/800 mg once daily for 5 days/300 mg single dose)
Slovenian: trimetoprim/sulfametoksazol (kotrimoksazol)/lamivudin (160 mg/800 mg enkrat na dan 5 dni/300 mg enkratni odmerek)
English: Studies with lamivudine show that plasma concentrations (AUC) are increased in patients with renal dysfunction due to decreased clearance.
Slovenian: Študije z lamivudinom kažejo, da so pri bolnikih z ledvično disfunkcijo plazemske koncentracije (AUC) zaradi manjšega očistka povečane.
English: There is no evidence from clinical studies that abacavir is hepatotoxic.
Slovenian: V kliničnih študijah ni dokazov, da bi bil abakavir hepatotoksičen.
English: Additional risk minimisation activity
Slovenian: Dodatna aktivnost za zmanjšanje tveganja
English: Tell your doctor or pharmacist if you are taking any of these.
Slovenian: Posvetujte se z zdravnikom ali farmacevtom, če jemljete katerokoli od teh zdravil.
English: The other ingredients are microcrystalline cellulose, sodium starch glycollate and magnesium stearate in the core of the tablet.
Slovenian: Pomožne snovi so mikrokristalna celuloza, natrijev karboksimetilškrob in magnezijev stearat v jedru tablete.
English: - If you have any further questions ask your doctor or pharmacist.
Slovenian: - Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom ali farmacevtom.
English: Percent with <400 copies/mL vRNA
Slovenian: Odstotek z < 400 kopij/ml vRNA
English: ANTIHISTAMINES (HISTAMINE H2 RECEPTOR ANTAGONISTS) Ranitidine/Abacavir
Slovenian: ANTIHISTAMINIKI (ANTAGONISTI HISTAMINSKIH RECEPTORJEV H2) ranitidin/abakavir
English: Mechanism of action: Abacavir and lamivudine are NRTIs, and are potent selective inhibitors of HIV-1 and HIV-2 (LAV2 and EHO) replication.
Slovenian: Mehanizem delovanja: Abakavir in lamivudin sta nukleozidna in nukleotidna zaviralca reverzne transkriptaze (NRTI) in sta močna selektivna zaviralca replikacije virusa HIV-1 in HIV-2 (LAV2 in EHO).
English: Common: Rash, alopecia Rare: Angioedema
Slovenian: Pogosti: eksantem, alopecija Redki: angioedem
English: Virologic Response
Slovenian: Virusni odziv
English: (e.g. Ziagen, Trizivir, Triumeq)
Slovenian: Trizivir, Triumeq in Ziagen).
English: • a decrease in the number of cells involved in blood clotting (thrombocytopenia).
Slovenian: • zmanjšanje števila krvnih celic, ki so pomembne pri strjevanju krvi (trombocitopenija).
English: Those reported in at least 10% of patients with a hypersensitivity reaction are in bold text.
Slovenian: 10 % bolnikov s preobčutljivostno reakcijo, so navedeni v krepkem tisku.
English: Neither abacavir nor lamivudine were mutagenic in bacterial tests, but consistent with other nucleoside analogues, they inhibit cellular DNA replication in in vitro mammalian tests such as the mouse lymphoma assay.
Slovenian: Niti abakavir niti lamivudin nista pokazala mutagenosti pri testih na bakterijah, vendar pa, skladno z drugimi nukleozidnimi analogi, inhibirata replikacijo celične DNK v in vitro testih na celicah sesalcev, npr. celicah mišjega limfoma.
English: The EU SPC provides detailed information and advice relating to ABC HSR
Slovenian: Rutinske aktivnosti za EU SPC vsebuje podrobne informacije in nasvete v zvezi s
English: The most common symptoms are:
Slovenian: Najpogostejša simptoma sta:
English: Special care is advised in this age group due to age associated changes such as the decrease in renal function and alteration of haematological parameters.
Slovenian: Pri tej starostni skupini je, zaradi s starostjo povezanih sprememb, kot sta zmanjšano delovanje ledvic in spremembe v hematoloških parametrih, potrebna posebna previdnost.
English: With the exception of a negative in vivo rat micronucleus test, there are no data available on the effects of the combination of abacavir and lamivudine in animals.
Slovenian: Z izjemo negativnega mikronukleus testa, izvedenega in vivo na podganah, drugi podatki o učinkih kombinacije abakavir in lamivudin pri živalih niso na voljo.
English: There have been reports of mitochondrial dysfunction in HIVnegative infants exposed in utero and/or post-natally to nucleoside analogues (see section 4.4).
Slovenian: Opisani so primeri motenega delovanja mitohondrijev pri HIV-negativnih dojenčkih, ki so bili in utero in/ali po rojstvu izpostavljeni nukleozidnim analogom (glejte poglavje 4.4).
English: • Clinical Description of abacavir HSR
Slovenian: • Klinični opis HSR na abakavir
English: Appropriate use of abacavir and lamivudine can be guided using these currently recommended resistance algorithms.
Slovenian: Vodilo za uporabo abakavirja in lamivudina so lahko trenutno veljavni algoritmi odpornosti.
English: The results are summarised by subgroup in the table below:
Slovenian: Rezultati so povzeti po podskupinah v spodnji preglednici:
English: 1) you get a skin rash OR
Slovenian: 1) kožni izpuščaj ALI
English: Clinical studies have shown that there are no clinically significant interactions between abacavir and lamivudine.
Slovenian: S kliničnimi študijami je bilo dokazano, da med abakavirjem in lamivudinom ni klinično pomembnih interakcij.
English: Methadone/Abacavir (40 to 90mg once daily for 14 days/600mg single dose, then 600mg twice daily for 14 days)
Slovenian: OPIOIDI metadon/abakavir (40 to 90mg enkrat na dan, 14 dni/600mg enkratni odmerek, nato 600mg dvakrat na dan 14 dni)
English: The mean time to maximal serum concentrations (tmax) is about 1.5 hours and 1.0 hour for abacavir and lamivudine, respectively.
Slovenian: Povprečen čas za dosego največje serumske koncentracije (tmax) je pri abakavirju približno 1,5 ure in pri lamivudinu 1,0 uro.
English: Carefully read all the information about hypersensitivity reactions in Section 4 of this leaflet.
Slovenian: Natančno preberite vse informacije o preobčutljivostnih reakcijah v poglavju 4 tega navodila.
English: • liver disorders, such as jaundice, enlarged liver or fatty liver, inflammation (hepatitis)
Slovenian: • težave z jetri, kot so zlatenica, povečana ali zamaščena jetra, vnetje jeter (hepatitis);
English: • a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome), and a more severe form causing skin peeling in more than
Slovenian: • razširjen izpuščaj z mehurji in lupljenjem kože, zlasti okrog ust, nosu, oči in spolovil (StevensJohnsonov sindrom), ter hujša oblika, ki povzroči lupljenje kože na več kot 30 % površine telesa (toksična epidermalna nekroliza);
English: The overall selection frequency for M184V or M184I was high (54%), and less common was the selection of L74V (5%), K65R (1%) and Y115F (1%) (see table below).
Slovenian: Celotna pogostnost selekcije M184V ali M184I je bila visoka (54 %), redkejše so bile selekcije L74V (5 %), K65R (1 %) in Y115F (1 %)
English: There are conflicting data in some comparative studies with Kivexa i.e. HEAT, ACTG5202 and ASSERT:
Slovenian: Nekatere primerjalne študije zdravila Kivexa tj. HEAT, ACTG5202 in ASSERT, vsebujejo nasprotujoče si podatke.
English: This potential difference is sufficiently small to draw an overall conclusion of non-inferiority of abacavir once daily over abacavir twice daily.
Slovenian: Ta možna razlika je dovolj majhna, da lahko postavimo končen zaključek, da sta si režima odmerjanja abakavirja enkrat ali dvakrat dnevno enakovredna.
English: The absolute bioavailability of oral abacavir and lamivudine in adults is about 83% and 80-85% respectively.
Slovenian: Pri odraslih znaša absolutna biološka uporabnost peroralno danega abakavirja približno 83 %, peroralno danega lamivudina pa približno 80-85 %.
English: In long-term oral carcinogenicity studies in rats and mice, lamivudine did not show any carcinogenic potential.
Slovenian: V raziskavah karcinogenosti pri dolgoročni peroralni uporabi na podganah in miših lamivudin ni pokazal karcinogenega potenciala.
English: Paediatric population: The safety and efficacy of Kivexa in children weighing less than 25 kg has not been established.
Slovenian: Varnost in učinkovitost zdravila Kivexa pri otrocih, ki tehtajo manj kot 25 kg, še nista bili dokazani.
English: No additional safety issues have been identified in paediatric subjects receiving either once or twice daily dosing compared to adults.
Slovenian: Pri pediatričnih preiskovancih, ki so prejemali zdravljenje bodisi enkrat ali dvakrat na dan, niso v primerjavi z odraslimi ugotovili nobenih dodatnih varnostnih težav.
English: This recurrence is usually more severe than on initial presentation, and may include life-threatening hypotension and death.
Slovenian: Takšna ponovitev je po navadi hujša od prvega pojava in lahko vključuje življenjsko nevarno hipotenzijo in smrt.
English: Genotypic sensitivity scores were not obtained for all patients at baseline.
Slovenian: Ocene genotipske občutljivosti izhodiščno niso bile ugotovljene za vse bolnike.
English: Some medicines interact with Kivexa These include:
Slovenian: Nekatera zdravila medsebojno delujejo z zdravilom Kivexa Med takšnimi so:
English: Pharmacogenetic Testing
Slovenian: Farmakogenetsko testiranje
English: In vivo resistance
Slovenian: Odpornost in vivo
English: Pharmacokinetic data has been obtained for abacavir and lamivudine separately.
Slovenian: Farmakokinetični podatki so bili pridobljeni za abakavir in lamivudin posamezno.
English: Each susceptible drug in the regimen received a score of 1 and drugs for which the ANRS algorithm predicts resistance were ascribed the value ‘0'.
Slovenian: Vsako zdravilo z občutljivostjo v shemi je dobilo oceno 1, zdravilom, pri katerih algoritem ANRS napoveduje odpornost, pa je bila dodeljena vrednost
English: If lamivudine is being used concomitantly for the treatment of HIV and hepatitis B virus (HBV), additional information relating to the use of lamivudine in the treatment of hepatitis B infection can be found in the Summary of Product Characteristics for products containing lamivudine that are indicated for the treatment of HBV.
Slovenian: V primeru sočasnega zdravljenja okužbe s HIV in virusa hepatitisa B (HBV) z lamivudinom lahko dodatne informacije, ki se nanašajo na uporabo lamivudina pri zdravljenju okužbe z virusom hepatitisa B, najdete v povzetku glavnih značilnosti zdravila pri zdravilih, ki vsebujejo lamivudin in so indicirana za zdravljenje HBV.
English: Common: headache
Slovenian: Pogosti: glavobol
English: However, paediatric pharmacokinetic studies with tablet formulations have demonstrated that once daily dosing provides equivalent AUC24 to twice daily dosing of the same total daily dose.
Slovenian: Pediatrične farmakokinetične študije s tabletami so pokazale, da odmerjanje enkrat na dan zagotavlja ekvivalentno AUC24 kot odmerjanje enakega celotnega dnevnega odmerka dvakrat na dan.
English: Based on the above patients are advised to contact their physician immediately to determine whether they should stop taking abacavir if:
Slovenian: Na podlagi omenjenega je treba bolnikom naročiti, naj se takoj posvetujejo s svojim zdravnikom, da bodo ugotovili, ali morajo prenehati jemati abakavir, če: • se pojavi izpuščaj na koži ALI
English: You must carefully read all the information under ‘Hypersensitivity reactions' in the panel in Section 4.
Slovenian: Natančno preberite vse informacije v okviru "Preobčutljivostne reakcije" v poglavju 4.
English: Driving and using machines Kivexa may cause side effects which could affect your ability to drive or use machines.
Slovenian: Zdravilo Kivexa lahko povzroči neželene učinke, ki lahko vplivajo na vašo sposobnost upravljanja vozil ali strojev.
English: Rare: pancreatitis has been reported, but a causal relationship to abacavir treatment is uncertain
Slovenian: Redki: poročali so o pankreatitisu, vendar pa vzročna povezava z zdravljenjem z abakavirjem ni zanesljiva.
English: Abacavir is also excreted into human milk.
Slovenian: Abakavir se izloča v materino mleko tudi pri človeku.
English: The combination of abacavir and lamivudine has demonstrated antiviral activity in cell culture against non-subtype B isolates and HIV-2 isolates with equivalent antiviral activity as for subtype B isolates.
Slovenian: Kombinacija abakavirja in lamivudina je v celični kulturi delovala protivirusno proti izolatom podtipa ne-B in izolatom HIV-2 z enakovredno protivirusno aktivnostjo kot pri izolatih podtipa B. Odpornost
English: No specific symptoms or signs have been identified following acute overdose with abacavir or lamivudine, apart from those listed as undesirable effects.
Slovenian: Po akutnem zaužitju prevelikega odmerka abakavirja ali lamivudina niso poročali o posebnih simptomih ali znakih, razen tistih, ki so navedeni kot neželeni učinki.
English: Efficacy Outcome at Week 48 in CNA30021 by baseline HIV-1 RNA and CD4 Categories (ITTe TLOVR ART naïve subjects).
Slovenian: Izid učinkovitosti 48. teden v CNA30021 po izhodiščnih kategorijah HIV-1 RNA in CD4 (ZNZ-I
English: - 88.3% with ABC/3TC vs 90.3% with TDF/FTC when taken with atazanavir/ritonovir as third drug, treatment difference -2.0% (95% CI -7.5%, 3.4%), - 87.4% with ABC/3TC vs 89.2% with TDF/FTC, when taken with efavirenz as third drug, treatment difference -1.8% (95% CI -7.5%, 3.9%).
Slovenian: - 88,3 % z ABC/3TC in 90,3 % z TDF/FTC med uporabo z atazanavirjem/ritonavirjem kot tretjim zdravilom, razlika med zdravljenjema -2,0 % (95 % IZ: -7,5 %, 3,4 %), - 87,4 % z ABC/3TC in 89,2 % z TDF/FTC med uporabo z efavirenzem kot tretjim zdravilom, razlika med zdravljenjema -1,8 % (95 % IZ: -7,5 %, 3,9 %).
English: Before initiating treatment with abacavir, screening for carriage of the HLA-B*5701 allele should be performed in any HIV-infected patient, irrespective of racial origin (see section 4.4).
Slovenian: Pred uvedbo zdravljenja z abakavirjem je pri vsakem bolniku, okuženim z virusom HIV, treba opraviti presejalni test za prisotnost alela HLA-B*5701, ne glede na rasno poreklo (glejte poglavje 4.4).
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
Slovenian: Pri bolnikih z obstoječimi motnjami v delovanju jeter, vključno s kroničnim aktivnim hepatitisom, se med kombiniranim protiretrovirusnim zdravljenjem pogosteje pojavljajo nepravilnosti v delovanju jeter, zato je potrebno take bolnike nadzorovati v skladu s standardno prakso.
English: Rarely, patients who have stopped abacavir for reasons other than symptoms of HSR have also experienced life-threatening reactions within hours of re- initiating abacavir therapy (see Section 4.8 Description of selected adverse reactions).
Slovenian: V redkih primerih so se pri bolnikih, ki so abakavir prenehali jemati zaradi drugih razlogov, ne zaradi simptomov HSR, v nekaj urah po ponovni uvedbi zdravljenja z abakavirjem, pojavile življenjsko nevarne reakcije (glejte poglavje 4.8, Opis izbranih neželenih učinkov).
English: Intravenous studies with abacavir and lamivudine showed that the mean apparent volume of distribution is 0.8 and 1.3 l/kg respectively.
Slovenian: Študije z intravensko danim abakavirjem in lamivudinom so pokazale, da znaša srednji navidezni volumen porazdelitve 0,8 l/kg za abakavir in 1,3 l/kg za lamivudin.
English: HLA-B*5701 status must always be documented and explained to the patient prior to initiating therapy.
Slovenian: Status HLA-B*5701 je vedno treba dokumentirati in ga pred začetkom zdravljenja pojasniti bolniku.
English: The GSS was obtained from the Monogram reports with susceptible virus ascribed the values ‘1-4' based upon the numbers of drugs in the regimen and with virus with reduced susceptibility ascribed the value ‘0'.
Slovenian: občutljivim virusom so bile dodeljene vrednosti "1-4", odvisno od števila zdravil v shemi, virusom z zmanjšano občutljivostjo pa je bila pripisana vrednost "0".
English: When possible, avoid chronic coadministration of Kivexa with medicinal products containing sorbitol or other osmotic acting poly-alcohols or monosaccharide alcohols (e.g. xylitol, mannitol, lactitol, maltitol).
Slovenian: Če je mogoče, se izognite kronični sočasni uporabi zdravila Kivexa z zdravili, ki vsebujejo sorbitol ali druge osmotsko delujoče polialkohole oziroma monosahardine alkohole (npr. ksilitol, manitol, laktitol, maltitol).
English: These medicines should not be used with Kivexa:
Slovenian: Zdravila, ki se ne smejo uporabljati skupaj z zdravilom Kivexa:
English: The results are summarised below:
Slovenian: Rezultati so povzeti spodaj:
English: MISCELLANEOUS Ethanol/Abacavir (0.7 g/kg single dose/600 mg single dose)
Slovenian: RAZNO etanol/abakavir (0.7 g/kg enkratni odmerek/600mg enkrati odmerek)
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to CART.
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo CART - combination antiretroviral therapy ali obojim.
English: Clinical experience with the combination of abacavir and lamivudine as a once daily regimen is mainly based on four studies in treatment-naïve subjects, CNA30021, EPZ104057 (HEAT study), ACTG5202, and CNA109586 (ASSERT study) and two studies in treatment-experienced subjects, CAL30001 and ESS30008.
Slovenian: Klinične izkušnje s kombinacijo abakavirja in lamivudina v shemi enkrat na dan temeljijo predvsem na štirih študijah pri še nezdravljenih (naivnih) preiskovancih (študije CNA30021, EPZ104057 (študija HEAT), ACTG5202 in CNA109586 (študija ASSERT)) ter na dveh študijah pri že zdravljenih preiskovancih, CAL30001 in ESS30008.
English: Delay in stopping treatment with abacavir after the onset of hypersensitivity may result in an immediate and life-threatening reaction.
Slovenian: Če se s prenehanjem zdravljenja z abakavirjem po pojavu preobčutljivosti odlaša, lahko pride do takojšnje in življenjsko nevarne reakcije.
English: Some people who take abacavir may develop a hypersensitivity reaction (a serious allergic reaction), which can be life-threatening if they continue to take abacavir containing products.
Slovenian: Nekaterim bolnikom, ki jemljejo abakavir, se lahko pojavi preobčutljivostna reakcija (resna alergijska reakcija), ki je lahko življenjsko nevarna, če še naprej jemljejo zdravila, ki vsebujejo abakavir.
English: The absolute bioavailability of lamivudine (approximately 58 to 66%) was lower and more variable in paediatric patients under 12 years of age.
Slovenian: Pri pediatričnih bolnikih, mlajših od 12 let, je bila absolutna biološka uporabnost lamivudina (približno 58-66 %) nižja in bolj variabilna.
English: TAMs might be selected when thymidine analogs are associated with abacavir.
Slovenian: Do selekcije mutacij timidinskih analogov lahko pride, če so timidinski analogi povezani z abakavirjem.
English: Tablet Core magnesium stearate microcrystalline cellulose sodium starch glycollate
Slovenian: Jedro tablete magnezijev stearat mikrokristalna celuloza natrijev karboksimetilškrob
English: They were randomised to receive either abacavir (ABC) 600 mg once daily or 300 mg twice daily, in combination with lamivudine 300 mg once daily and efavirenz 600 mg once daily.
Slovenian: Randomizirani so bili tako, da so prejemali kombinacijo abakavirja (ABC) bodisi v odmerku 600 mg enkrat dnevno bodisi v odmerku 300 mg dvakrat dnevno, lamivudina v odmerku 300 mg enkrat dnevno in efavirenza v odmerku 600 mg enkrat dnevno.
English: Following a single dose of 600 mg of abacavir, the mean (CV) Cmax is 4.26 µg/ml (28%) and the mean (CV) AUC∞ is 11.95 µg.h/ml (21%).
Slovenian: Po vnosu abakavirja v enkratnem 600 mg odmerku znaša srednja (CV) Cmax 4,26 µg/ml (28 %), srednja (CV) AUC∞ pa 11,95 µg.h/ml (21 %).
English: Occasionally hypersensitivity reactions have developed in people who start taking abacavir containing products again, but who had only one symptom on the Alert Card before they stopped taking it.
Slovenian: Občasno so se preobčutljivostne reakcije pojavile pri ljudeh, ki so znova začeli jemati zdravila, ki vsebujejo abakavir in so imeli prej, preden so ga prenehali jemati, le enega od simptomov z opozorilne kartice.
English: Common: Cough, nasal symptoms
Slovenian: Pogosti: kašelj, nazalni simptomi
English: If you accidentally take too much Kivexa, tell your doctor or your pharmacist, or contact your nearest hospital emergency department for further advice.
Slovenian: Če ste vzeli večji odmerek zdravila Kivexa, kot bi smeli Če ste pomotoma vzeli preveč zdravila Kivexa, se nemudoma posvetujte z zdravnikom ali farmacevtom, ali se za dodatne nasvete obrnite na oddelek nujne pomoči najbližje bolnišnice.
English: Even patients who don't have the HLA-B*5701 gene may still develop a hypersensitivity reaction (a serious allergic reaction), described in this leaflet in the panel headed ‘Hypersensitivity reactions'.
Slovenian: Tudi pri bolnikih, ki nimajo gena HLA-B*5701, se lahko pojavi preobčutljivostna reakcija (huda alergijska reakcija), ki je v tem navodilu opisana pod naslovom »Preobčutljivostne reakcije«.