FrancophonIA/ELRC3.0 huggingface dataset:
English: Darunavir Krka 400mg film-coated tabletsareavailable in bottlescontaining 30 film-coated tablets (1 bottleof 30 film-coated tablets), 60 film-coated tablets (2 bottlesof 30 film-coated tablets), 90 filmcoated tablets (3 bottlesof 30 film-coated tablets)and 180 film-coated tablets (6 bottlesof 30 filmcoated tablets)in a box.
Danish: Darunavir Krka 400 mg filmovertrukne tabletter er tilgængelige i beholdere indeholdende 30 filmovertrukne tabletter (1 beholder med 30 filmovertrukne tabletter), 60 filmovertrukne tabletter (2 beholdere med 30 filmovertrukne tabletter), 90 filmovertrukne tabletter (3 beholdere med 30 filmovertrukne tabletter) og 180 filmovertrukne tabletter (6 beholdere med 30 filmovertrukne tabletter) i en æske.
English: The use of carbamazepine with darunavir co-administered with cobicistat is contraindicated (see section 4.3).
Danish: Brug af carbamazepin sammen med darunavir co-administreret med cobicistat er kontraindiceret (se pkt.
English: Gastrointestinal disorders very common diarrhoea, nausea common vomiting, abdominal pain, abdominal distension, dyspepsia, flatulence, pancreatic enzymes increased uncommon pancreatitis acute
Danish: Mave-tarm-kanalen meget almindelig diarré, kvalme almindelig opkastning, mavesmerter, abdominal distension, dyspepsi, flatulens, forhøjede pancreas-enzymer ikke almindelig akut pancreatitis
English: With Baseline CD4+ cell count (x 10
Danish: Med CD4+celletal (× 10
English: Darunavir may therefore have different recommendations for concomitant medications depending on whether the compound is boosted with ritonavir or cobicistat.
Danish: Der kan derfor være forskellige anbefalinger for darunavir og samtidige lægemidler afhængigt af, om darunavir er boostet med ritonavir eller cobicistat.
English: Reproductive system and breast disorders uncommon erectile dysfunction, gynaecomastia
Danish: Det reproduktive system og mammae ikke almindelig erektil dysfunktion, gynækomasti
English: Cobicistat and ritonavir inhibit CYP3A, thereby increasing the plasma concentrations of darunavir considerably.
Danish: Cobicistat og ritonavir-hæmmer CYP3A, hvilket øger plasmakoncentrationen af darunavir betragteligt.
English: Co-administration of boosted darunavir and naloxegol is contraindicated.
Danish: Co-administration af boostet darunavir og naloxegol er kontraindiceret.
English: Avanafil to treat erectile dysfunction
Danish: Avanafil til behandling af impotens
English: Cmax, ng/mL AUC24h, ng.h/mL Cmin, ng/mL
Danish: Cmax, ng/ml AUC24t, ng∙t/ml Cmin, ng/ml
English: Darunavir Krka might increase sugar levels in the blood.
Danish: Darunavir Krka kan forhøje blodsukkerniveauet.
English: HERBAL PRODUCTS St John's wort (Hypericum perforatum)
Danish: NATURLÆGEMIDLER Perikon (Hypericum perforatum)
English: Increasing the dose of ritonavir from that recommended in section 4.2 did not significantly affect darunavir concentrations.
Danish: 4.2 påvirkede ikke koncentrationen af darunavir i signifikant grad.
English: Therefore the same once daily dosage may be used in treatment-experienced adolescents aged 12 to < 18 years and weighing at least 40 kg without darunavir resistance associated mutations (DRV-RAMs)* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: Derfor kan den samme daglige dosis anvendes til behandlingserfarne unge i alderen 12 til <18 år med en legemsvægt på mindst 40 kg, der ikke har mutationer associeret med darunavirresistens (DRV-RAMs)*, og som har plasma-hiv-1-RNA <100.000 kopier/ml og CD4+-celletal ≥100 × 10
English: Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of darunavir and ritonavir (e.g. rifampicin, St John's wort, lopinavir).
Danish: Lægemidler, der inducerer CYP3Aaktivitet, ville forventes at øge clearance af darunavir og ritonavir, hvilket medfører en lavere plasmakoncentration af darunavir og ritonavir (f.eks. rifampicin, perikon, lopinavir).
English: OESTROGEN-BASED CONTRACEPTIVES Drospirenone
Danish: ØSTROGENBASERET PRÆVENTION Drospirenon
English: Indinavir 800 mg twice daily indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ darunavir AUC ↑ 24% darunavir Cmin ↑ 44% darunavir Cmax ↑ 11%
Danish: Indinavir 800 mg to gange daglig indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ darunavir AUC ↑ 24% darunavir Cmin ↑ 44% darunavir Cmax ↑ 11%
English: Co-administration of darunavir and ritonavir and other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (e.g. indinavir, azole antifungals like clotrimazole).
Danish: Co-administration af darunavir og ritonavir med andre lægemidler, som hæmmer CYP3A, kan nedsætte clearance af darunavir og ritonavir, hvilket kan medføre øgede plasmakoncentrationer af darunavir og ritonavir (f.eks. indinavir, azol antimykotika som clotrimazol).
English: Lovastatin and simvastatin are expected to have markedly increased plasma concentrations when coadministered with darunavir coadministered with low dose ritonavir.
Danish: Plasmakoncentrationen af lovastatin og simvastatin forventes at stige markant, når de gives sammen med darunavir coadministreret med lavdosis ritonavir.
English: The interaction trial showed a comparable daily systemic exposure for rifabutin between treatment at 300 mg once daily alone and 150 mg once every other day in combination with darunavir/ritonavir (600/100 mg twice daily) with an about 10fold increase in the daily exposure to the active metabolite 25-O-desacetylrifabutin.
Danish: Interaktionsstudiet viste en sammenlignelig daglig systemisk eksponering af rifabutin imellem behandling med 300 mg en gang daglig og 150 mg hver anden dag i kombination med darunavir/ritonavir (600/100 mg to gange daglig).
English: Concomitant use of boosted darunavir and corticosteroids that are metabolised by CYP3A (e.g. fluticasone propionate or other inhaled or nasal corticosteroids) may increase the risk of development of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression.
Danish: Samtidig brug af boostet darunavir og kortikosteroider, der metaboliseres via CYP3A (f.eks. fluticasonpropionat eller andre inhalerede eller nasale kortikosteroider) kan øge risikoen for systemiske kortikosteroidbivirkninger, herunder Cushings syndrom og binyresuppression.
English: Darunavir Krka cannot work properly without ritonavir and food.
Danish: Darunavir Krka kan ikke virke korrekt uden ritonavir og mad.
English: LABEL for bottle
Danish: ETIKET TIL BEHOLDER
English: 375 milligram darunavir + 50 milligram ritonavir twice a day between 30 and 40 kilograms
Danish: 375 mg Darunavir Krka + 50 mg ritonavir to gange dagligt mellem 30 og 40 kg
English: Postpartum (6-12 weeks) (n=16)
Danish: Post partum (6-12 uger) (n=16)
English: Instructions for children 3 years of age and above, weighing more than 40 kilograms Take 800 milligram Darunavir Krka (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) at the same time, once a day, every day.
Danish: Anvisninger for børn fra 3 år og opefter med en legemsvægt på mindst 40 kg - Tag hver dag 800 mg Darunavir Krka (2 tabletter a 400 mg Darunavir Krka eller 1 tablet a 800 mg Darunavir Krka) en gang dagligt og på samme tidspunkt.
English: Darunavir with low dose ritonavir with triazolam or oral midazolam is contraindicated (see section 4.3)
Danish: Darunavir med lavdosis ritonavir med triazolam eller oral midazolam er kontraindiceret (se pkt.
English: Therefore, coadministration of boosted darunavir and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3).
Danish: Co-administration af boostet darunavir og sildenafil til behandling af pulmonal arteriel hypertension er derfor kontraindiceret (se pkt.
English: In addition, pharmacokinetic modeling and simulation of darunavir exposures in paediatric patients across the ages of 3 to < 18 years confirmed the darunavir exposures as observed in the clinical studies and allowed the identification of weight-based darunavir/ritonavir once daily dosing regimens for paediatric patients weighing at least 15 kg that are either ART-naïve or treatment-experienced paediatric patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: Yderligere bekræftede en farmakokinetisk model og simulering af darunavireksponeringer hos pædiatriske patienter i alderen 3 til <18 år de darunavireksponeringer, som blev observeret i de kliniske studier, og gav mulighed for at fastlægge vægtbaserede doser af darunavir/ritonavir en gang daglig hos pædiatriske patienter med en legemsvægt på mindst 15 kg, som er enten ART-naive eller behandlingserfarne uden DRV-RAMs* og med plasma-hiv-1-RNA <100.000 kopier/ml og CD4+- celletal ≥100 × 10
English: Nevirapine 200 mg twice daily nevirapine AUC ↑ 27% nevirapine Cmin ↑ 47% nevirapine Cmax ↑ 18% darunavir: concentrations were consistent with historical data (↑ nevirapine from CYP3A inhibition)
Danish: Nevirapin 200 mg to gange daglig nevirapin AUC ↑ 27% nevirapin Cmin ↑ 47% nevirapin Cmax ↑ 18% darunavir: koncentrationerne var i overensstemmelse med historiske data.
English: HIV ANTIRETROVIRALS Integrase strand transfer inhibitors Dolutegravir dolutegravir AUC ↓ 22% dolutegravir C24h ↓38% dolutegravir Cmax ↓ 11% darunavir ↔*
Danish: Dolutegravir dolutegravir AUC ↓ 22% dolutegravir C24h ↓ 38% dolutegravir Cmax ↓ 11% darunavir ↔*
English: Boosted darunavir can be coadministered with H2-receptor antagonists without dose adjustments.
Danish: Boostet darunavir kan administreres sammen med H2receptorantagonister uden dosisjusteringer.
English: Always take with ritonavir and food.
Danish: Du skal altid tage Darunavir Krka med ritonavir og mad.
English: ≥ 30 kg-< 40 kg 675 mg darunavir /100 mg ritonavir once daily
Danish: ≥30 kg-<40 kg 675 mg darunavir/100 mg ritonavir en gang dagligt
English: Lurasidone Pimozide Sertindole
Danish: Perphenazin Risperidon Thioridazin Lurasidon Pimozid Sertindol
English: Darunavir Krka cannot work properly without food.
Danish: Darunavir Krka virker ikke korrekt uden mad.
English: d
Danish: b
English: You will require a different dose of Darunavir Krka which cannot be administered with these 600 milligram tablets.
Danish: Måske har du brug for en anden dosis af Darunavir Krka, som ikke kan sammensættes med 400 mg eller 800 mg tabletterne.
English: Darunavir co-administered with low dose ritonavir and amiodarone, bepridil, dronedarone, ivabradine, quinidine, or ranolazine is contraindicated (see section 4.3).
Danish: Darunavir administreret sammen med lavdosis ritonavir og amiodaron, bepridil, dronedaron, ivabradin, kinidin eller ranolazin er kontraindiceret (se pkt.
English: The recommended dose regimen is 600 mg twice daily taken with ritonavir 100 mg twice daily taken with food.
Danish: Den anbefalede dosis er 600 mg to gange dagligt sammen med ritonavir 100 mg to gange dagligt i forbindelse med et måltid.
English: 100 milligram ritonavir oral solution: 80 milligram per milliliter
Danish: 100 mg ritonavir oral opløsnig: 80 mg/ml
English: Buprenorphine/naloxone (medicines to treat opioid dependence) Salmeterol (medicine to treat asthma)
Danish: - Buprenorphin/naloxon (medicin til behandling af afhængighed af morfin og lignende).
English: The Darunavir Krka 400 and 800 milligram tablets are used to treat adults and children (3 years of age and above, at least 40 kilograms body weight) who are infected by HIV and who have not used antiretroviral medicines before.
Danish: Darunavir Krka 400 mg og 800 mg tabletter anvendes til at behandle voksne og børn (fra 3 år og opefter med en legemsvægt på mindst 40 kg), som er smittet med hiv, og - som ikke før har fået medicin til behandling af hiv - hos nogle patienter, som før har fået medicin til behandling af hiv (din læge vil afgøre dette).
English: Concomitant use of colchicine and darunavir co-administered with low dose ritonavir may increase the exposure to colchicine.
Danish: Samtidig anvendelse af colchicin og darunavir administreret sammen med lavdosis ritonavir kan øge eksponeringen for colchicin.
English: Fesoterodine, solifenacin(to treat urologic disorders).
Danish: - Fesoterodin, solifenacin(til behandling af sygdomme i urinvejene).
English: If you forget to take Darunavir Krka
Danish: Hvis du har taget for meget Darunavir Krka
English: Pravastatin 40 mg single dose pravastatin AUC ↑ 81% pravastatin Cmin ND pravastatin Cmax ↑ 63%
Danish: Pravastatin 40 mg som enkeltdosis pravastatin AUC ↑ 81%
English: Concomitant administration of boosted darunavir with dabigatran or ticagrelor is contraindicated (see section 4.3).
Danish: Samtidig administration af boostet darunavir og dabigatran eller ticagrelor er kontraindiceret (se pkt.
English: Darunavir binds predominantly to α1-acid glycoprotein.
Danish: Darunavir bindes hovedsageligt til surt α1-glykoprotein.
English: Pharmacokinetic results of total darunavir after administration of darunavir/cobicistat 800/150 mg once daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy, and postpartum Pharmacokinetics of total darunavir (mean ± SD)
Danish: Farmakokinetiske resultater for total-darunavir efter administration af 800/150 mg darunavir/cobicistat en gang dagligt som del af et antiretroviralt regime i andet trimester af graviditeten, tredje trimester af graviditeten og post partum Farmakokinetik for total-darunavir (Gennemsnit ± SD)
English: For further information on cobicistat, consult the cobicistat Summary of Product Characteristics.
Danish: For yderligere oplysninger om cobicistat, se produktresuméet for cobicistat.
English: An increase of systemic exposure to darunavir was observed when darunavir co-administered with 100 mg ritonavir was co-administered with rifabutin (150 mg once every other day).
Danish: Der er observeret øget systemisk eksponering af darunavir ved samtidig brug af rifabutin (150 mg hver anden dag) og darunavir administreret sammen med 100 mg ritonavir.
English: 150 mg twice daily darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
Danish: 150 mg to gange daglig darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
English: Darunavir co-administered with low dose ritonavir must not be used concomitantly with products containing St John's wort (Hypericum perforatum) (see section 4.3).
Danish: Darunavir administreret sammen med lavdosis ritonavir må ikke anvendes samtidig med produkter, der indeholder perikon (Hypericum perforatum) (se pkt.
English: Boosted darunavir with triazolam or oral midazolam is contraindicated (see section 4.3)
Danish: Boostet darunavir med triazolam eller oral midazolam er kontraindiceret (se pkt.
English: Blood and lymphatic system disorders uncommon thrombocytopenia, neutropenia, anaemia, leukopenia rare increased eosinophil count
Danish: Blod og lymfesystemet ikke almindelig trombocytopeni, neutropeni, anæmi, leukopeni sjælden forøget eosinofiltal
English: Efficacy of darunavir 800 mg once daily co-administered with 100 mg ritonavir once daily in ARTexperienced patients
Danish: Virkning af darunavir 800 mg en gang dagligt co-administreret med 100 mg ritonavir en gang dagligt hos ART-erfarne patienter
English: 400 mg film-coated tablets:
Danish: 400 mg filmovertrukne tabletter:
English: Darunavir KrKa 600 mg film coated tablets must not be chewed or crushed.
Danish: Darunavir Krka 600 mg filmovertrukne tabletter må ikke tygges eller knuses.
English: Concomitant use of salmeterol and boosted darunavir is not recommended.
Danish: Samtidig anvendelse af salmeterol og boostet darunavir anbefales ikke.
English: Concomitant use with strong CYP3A inducers is contraindicated, since these may reduce the exposure to cobicistat and darunavir leading to loss of therapeutic effect.
Danish: induktorer er kontraindiceret, eftersom disse kan reducere eksponeringen forcobicistat og darunavir med efterfølgende tab af terapeutisk effekt.
English: Caution is warranted and therapeutic concentration monitoring, if available, is recommended for these antiarrhythmics when coadministered with darunavir with low dose ritonavir.
Danish: Der skal udvises forsigtighed, og om muligt anbefales monitorering af terapeutisk koncentration for disse antiarytmika ved coadministration med darunavir og lavdosis ritonavir.
English: 800 mg film-coated tablets:
Danish: 800 mg filmovertrukne tabletter:
English: Treatment with darunavir/cobicistat 800/150 mg during pregnancy results in low darunavir exposure (see sections 4.4 and 5.2).
Danish: Behandling med darunavir/cobicistat 800/150 mg under graviditet fører til lav eksponering for darunavir (se pkt.
English: St John's wort is expected to decrease the plasma concentrations of darunavir and ritonavir.
Danish: Perikon forventes at nedsætte plasmakoncentrationen af darunavir og ritonavir.
English: Darunavir co-administered with low dose ritonavir should be used during pregnancy only if the potential benefit justifies the potential risk.
Danish: Darunavir co-administreret med lavdosis ritonavir, bør kun anvendes under graviditet, hvis den mulige fordel opvejer den mulige risiko.
English: Co-administration with darunavir coadministered with cobicistat is not recommended (see section 4.4).
Danish: Co-administration med darunavir co-administreret med cobicistat kan ikke anbefales (se pkt.
English: No dose adjustment for darunavir /ritonavir is recommended.
Danish: Der er ikke anbefalet dosisjustering af darunavir/ritonavir.
English: It is not recommended to coadminister darunavir with low dose ritonavir and boceprevir.
Danish: Det anbefales ikke at coadministrere darunavir med lavdosis ritonavir og boceprevir.
English: Darunavir boosted with cobicistat is more sensitive for CYP3A induction: concomitant use of darunavir/cobicistat and strong CYP3A inducers is therefore contraindicated (see section 4.3),and concomitant use with weak to moderate CYP3A inducers is not recommended (see section 4.5).
Danish: Darunavir boostet med cobicistat er mere følsomt over for CYP3A-induktion: samtidig brug af darunavir/cobicistat og potente CYP3A-induktorer er derfor kontraindiceret (se pkt.
English: Co-administration of domperidone with boosted darunavir is contraindicated.
Danish: Co-administration af domperidon og boostet darunavir er kontraindiceret.
English: The interaction profile of darunavir depends on whether ritonavir or cobicistat is used as pharmacokinetic enhancer.
Danish: Interaktionsprofilen for darunavir er afhængig af, om ritonavir eller cobicistat benyttes som farmakokinetisk forstærker.
English: The interaction profile of darunavir may differ depending on whether ritonavir or cobicistat is used as pharmacoenhancer.
Danish: Interaktionsprofilen for darunavir kan være forskellig afhængigt af, om ritonavir eller cobicistat benyttes som farmakokinetisk forstærker.
English: Concomitant use of colchicine and boosted darunavir may increase the exposure to colchicine.
Danish: Samtidig anvendelse af cochicin og boostet darunavir kan øge eksponeringen for colchicin.
English: The use of boosted darunavir and these anticoagulants is not recommended.
Danish: Brug af boostet darunavir sammen med disse antikoagulantia frarådes.
English: Carbamazepine, clonazepam(to prevent seizures or to treat certain types of nerve pain) Colchicine (to treat gout or familial Mediterranean fever) Bosentan (to treat high blood pressure in the pulmonary circulation) Buspirone, clorazepate, diazepam, estazolam, flurazepam, midazolam when used as injection, zoldipem (sedative agents)
Danish: (til behandling af depression og angst) - Maraviroc (til hiv-infektion) - Methadon (til behandling af opioidafhængighed) - Carbamazepin, clonazepam (til forebyggelse af krampeanfald eller til behandling af visse typer nervesmerter) - Colchicin (til behandling af urinsur gigt eller familiær middelhavsfeber) - Bosentan (til behandling af for højt blodtryk i lungekredsløbet) - Buspiron, clorazepat, diazepam, estazolam, flurazepam, midazolam, når det tages som injektion, zoldipem (beroligende midler) - Perphenazin, risperidon, thioridazin (til behandling af psykiske lidelser) - Metformin (til behandling af type 2-diabetes).
English: Concomitant use of salmeterol and boosted darunavir may increase plasma concentrations of salmeterol.
Danish: Samtidig anvendelse af salmeterol og boostet darunavir kan øge plasmakoncentrationen af salmeterol.
English: Co-administration of darunavir and ritonavir with medicinal products which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result in increased plasma concentrations of these medicinal products, which could increase or prolong their therapeutic effect and adverse reactions.
Danish: Coadministration af darunavir og ritonavir med lægemidler, som primært metaboliseres af CYP2D6 (såsom flecainid, propafenon, metoprolol), kan resultere i en øget plasmakoncentration af disse lægemidler, hvilket kan øge eller forlænge deres terapeutiske effekt og bivirkninger.
English: ≥ 15 kg-< 30 kg 600 mg darunavir/100 mg ritonavir once daily
Danish: ≥15 kg-<30 kg 600 mg darunavir/100 mg ritonavir en gang dagligt
English: Skin and subcutaneous tissue disorders common rash (including macular, maculopapular, papular, erythematous and pruritic rash), pruritus uncommon angioedema, generalised rash, allergic dermatitis, urticaria, eczema, erythema, hyperhidrosis, night sweats, alopecia, acne, dry skin, nail pigmentation rare
Danish: Hud og subkutane væv almindelig udslæt (herunder makuløst, makulopapuløst, papuløst, erytematøst og kløende udslæt), pruritus ikke almindelig angioødem, generaliseret udslæt, allergisk dermatitis, urticaria, eksem, erytem, hyperhidrose, nattesved, alopeci, akne, tør hud, neglepigmentering sjælden
English: 600 mg once daily efavirenz AUC ↑ 21% efavirenz Cmin ↑ 17% efavirenz Cmax ↑ 15% darunavir AUC ↓ 13% darunavir Cmin ↓ 31% darunavir Cmax ↓ 15% (↑ efavirenz from CYP3A inhibition) (↓ darunavir from CYP3A induction)
Danish: 600 mg en gang daglig efavirenz AUC ↑ 21% efavirenz Cmin ↑ 17% efavirenz Cmax ↑ 15% darunavir AUC ↓ 13% darunavir Cmin ↓ 31% darunavir Cmax ↓ 15% (↑ efavirenz fra CYP3Ahæmning) (↓ darunavir fra CYP3Ainduktion)
English: Each film-coated tablet contains 400 mg or 800 mg darunavir.
Danish: Hver filmovertrukken tablet indeholder 400 mg eller 800 mg darunavir.
English: Metabolism and nutrition disorders common diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia, hyperlipidaemia uncommon gout, anorexia, decreased appetite, decreased weight, increased weight, hyperglycaemia, insulin resistance, decreased high density lipoprotein, increased appetite, polydipsia, increased blood lactate dehydrogenase
Danish: Metabolisme og ernæring almindelig diabetes mellitus, hypertriglyceridæmi, hyperkolesterolæmi, hyperlipidæmi ikke almindelig artritis urica, anoreksi, nedsat appetit, vægttab, vægtstigning, hyperglykæmi, insulinresistens, nedsat HDL, øget appetit, polydipsi, øget lactatdehydrogenase i blodet
English: Proportion (%) of patients with response (HIV-1 RNA < 50 copies/ml at week 24) to darunavir coadministered with ritonavir (600/100 mg twice daily) by baseline genotype a, and baseline darunavir
Danish: Patientandelen (%)med respons(hiv-1-RNA < 50 kopier/ml ved uge 24) over for darunavir co-administreret med ritonavir (600/100 mg to gange dagligt) efter genotype ved baselinea og darunavir FC ved baseline og efter brug af enfuvirtid (ENF): ”As treated-analyse” af POWER- og DUET-studierne.
English: Caution should be exercised when clarithromycin is combined with darunavir co-administered with low dose ritonavir.
Danish: Der skal udvises forsigtighed, når clarithromycin kombineres med darunavir administreret sammen med lavdosis ritonavir.
English: Based on theoretical considerations boosted darunavir is expected to increase the exposure of lomitapide when coadministered.
Danish: Baseret på teoretiske overvejelser forventes coadministreret boostet darunavir at øge eksponeringen for lomitapid.