FrancophonIA/ELRC3.0 huggingface dataset:
English: In a follow-up study where initially cleared patients with imiquimod 3.75% were followed for at least 14 months without any further AK-treatment, 40.5% of the patients showed sustained complete clearance of the whole treatment area (either full face or scalp) There are no data for imiquimod 3.75% on long-term clearance beyond that.
Slovenian: V nadaljevalni študiji, v kateri so najmanj 14 mesecev opazovali bolnike, ki so se zdravili z imikvomod 3,75 % in pri katerih so lezije na začetku izginile, nato pa niso več prejemali kakršnega koli nadaljnjega zdravljenja AK, se je pri 40,5 % bolnikov pokazala trajna popolna odprava na celotnem zdravljenem področju (bodisi celotnem obrazu ali lasišču).
English: Because of concern for heightened sunburn susceptibility, use of sunscreen is encouraged, and patients should minimise or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment) while using Zyclara.
Slovenian: bolniki pa naj med zdravljenjem z zdravilom Zyclara omejijo izpostavljanje naravni ali sončni svetlobi (uporaba solarija ali zdravljenje z UVA/B svetilkami) oziroma se mu izogibajo.
English: Remote site dermatologic reactions
Slovenian: Dermatološke reakcije na oddaljenih mestih
English: Avoid contact with the eyes, lips and nostrils.
Slovenian: - Preprečite stik z očmi, ustnicami in nosnicami.
English: Do not cover the treated area with bandages or other dressings.
Slovenian: Zdravljenega predela ne prekrivajte s povoji ali obvezami.
English: If you miss a dose of Zyclara, wait until the next night to apply it and then continue with the regular schedule.
Slovenian: Če ste pozabili nanesti zdravilo Zyclara, počakajte in kremo nanesite naslednji večer, nato nadaljujte z običajnim urnikom zdravljenja.
English: Flu-like systemic signs and symptoms may accompany, or even precede, intense local skin reactions and may include fatigue, nausea, fever, myalgias, arthralgias, and chills.
Slovenian: Gripi podobni znaki in simptomi lahko spremljajo burne lokalne kožne reakcije, ki lahko zajemajo utrujenost, navzeo, zvišano telesno temperaturo, mialgije, artralgije in mrazenje, ali se celo pojavijo pred njimi.
English: Animals were administered imiquimod cream three times per week and were irradiated 5 days per week for 40 weeks.
Slovenian: Živalim so dajali imikvimod trikrat tedensko,
English: If your skin reacts badly or becomes too uncomfortable when using this medicine, stop applying the cream and wash the area with mild soap and water.
Slovenian: Če vaša koža resno reagira na to zdravilo ali povzroči čezmerno nelagodje, prenehajte z uporabo, umijte področje nanosa z blagim milom in vodo ter čim prej obvestite zdravnika ali farmacevta.
English: Methyl parahydroxybenzoate (E 218), and propyl parahydroxybenzoate (E 216), may cause allergic reactions (possibly delayed).
Slovenian: Metilparahidroksibenzoat (E 218) in propilparahidroksibenzoat (E2 16) lahko povzročita alergijske reakcije (lahko zapoznele).
English: A rest period of several days may be taken if required by the patient's discomfort or severity of the local skin reaction.
Slovenian: Če je potrebno, se lahko zdravljenje zaradi nelagodja bolnika ali resnosti lokalne reakcije na koži za nekaj dni prekine.
English: Methyl parahydroxybenzoate (E 218), and propyl parahydroxybenzoate (E 216) may cause allergic reactions (possibly delayed).
Slovenian: Metilparahidroksibenzoat (E218) in propilparahidroksibenzoat (E216) lahko povzročita alergijske reakcije (lahko zapoznele).
English: Saturable binding studies suggest membrane receptors for imiquimod exists on responding cells; these are called toll-like receptor 7 and 8.
Slovenian: imenujejo se tollu-podoben receptor 7 in 8.
English: Open a new sachet of Zyclara just before use and squeeze some cream onto your fingertip.
Slovenian: Zyclara in iztisnite nekaj kreme na konico prsta.
English: Zyclara (per application: up to 2 sachets, 250 mg imiquimod cream per sachet) should be applied once daily before bedtime to the skin of the affected treatment field (area) for two treatment cycles of 2 weeks each separated by a 2-week no-treatment cycle or as directed by the physician.
Slovenian: Zdravilo Zyclara (za en nanos: do 2 vrečici, 250 mg imikvimod kreme na vrečico) nanašamo enkrat na dan pred spanjem na kožo prizadetega predela v dveh dva tedna trajajočih ciklusih zdravljenja, med katerima je dvotedensko obdobje premora brez zdravljenja, če zdravnik ne odredi drugače.
English: If you experience these, stop using this medicine and tell your doctor immediately.
Slovenian: Če se pri vas pojavi kaj od naštetega, prenehajte uporabljati to zdravilo in se čim prej posvetujte z zdravnikom.
English: You should not use Zyclara if you are breast-feeding or plan to breast-feed.
Slovenian: Zdravila Zyclara ne smete uporabljati, če dojite ali nameravate dojiti.
English: Patients with reduced haematologic reserve have not been studied in clinical trials.
Slovenian: Bolnikov z zmanjšanimi hematološkimi vrednostmi v kliničnih preskušanjih niso preučevali.
English: Rub gently into the area until the cream vanishes.
Slovenian: Kremo nežno vtirajte v kožo, dokler se popolnoma ne vpije.
English: This might make you more susceptible to infections, make you bruise more easily or cause tiredness.
Slovenian: Zaradi zmanjšanega števila krvnih celic ste lahko bolj dovzetni za okužbe in pojav modric ali ste bolj utrujeni.
English: - Throat pain - Eye irritation - Swelling of the eyelid - Depression - Irritability - Dry mouth - Abdominal pain
Slovenian: - depresija, - razdražljivost, - suha usta,
English: During a pharmacokinetic study with imiquimod 3.75% cream following application of 2 sachets once daily (18.75 mg imiquimod/day) for up to three weeks to the entire face and/or scalp (approximately 200 cm2), low systemic absorption of imiquimod was observed in patients with AK. Steady-state levels were achieved in 2 weeks and time to maximal concentrations (Tmax) ranged between 6 and 9 hours after last application.
Slovenian: Med farmakokinetično študijo z imikvimod 3,75 % kremo so pri bolnikih z AK, ki so do tri tedne na celotni obraz in/ali lasišče (približno 200 cm2) nanašali 2 vrečici (18,75 mg imikvimoda/dan) na dan, opazili nizko sistemsko absorpcijo imikvimoda.
English: You should continue treatment as prescribed.
Slovenian: Nadaljujte z zdravljenem, kot vam je predpisal zdravnik.
English: 319 subjects with AK were treated with up to 2 sachets once daily of imiquimod 3.75% cream, or a matching vehicle cream for two treatment cycles of 2 weeks separated by a 2-week no-treatment cycle.
Slovenian: 319 preiskovancev z AK je bilo zdravljenih z do 2 vrečicama imikvimod 3,75 % kreme na dan ali ujemajočo se kremo z vehiklom v dveh 2-tedenskih ciklusih zdravljenja, med katerima je bil 2-tedenski odmor brez zdravljenja.
English: Zyclara contains methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol
Slovenian: Zdravilo Zyclara vsebuje metilparahidroksibenzoat, propilparahidroksibenzoat, cetilalkohol, stearilalkohol in benzil alkohol
English: Zyclara 3.75% cream
Slovenian: Zyclara 3,75 % krema
English: However, neither 2-week treatment cycle should be extended due to missed doses or rest periods.
Slovenian: V nobenem primeru pa se posameznega dvotedenskega ciklusa zdravljenja ne sme prekoračiti zaradi pozabljenih odmerkov ali obdobij prekinitve.
English: Subjects applied up to two sachets of Zyclara 3.75% cream or vehicle daily to the skin of the affected area (either entire face or balding scalp, but not both) for two 2-week treatment cycles separated by a 2-week no-treatment cycle.
Slovenian: Zyclara 3,75 % krema ali vehikla na površino prizadetega predela (bodisi celoten obraz bodisi neporaščeno lasišče, vendar ne oboje) v dveh 2-tedenskih ciklusih zdravljenja, med katerima je bilo 2tedensko obdobje premora brez zdravljenja.
English: United Kingdom.
Slovenian: Združeno kraljestvo (Velika Britanija).
English: - The other ingredients are isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), xanthan gum, purified water (see also section 2 “Zyclara contains methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol”).
Slovenian: - Druge sestavine zdravila so izostearinska kislina, benzilalkohol, cetilalkohol, stearilalkohol, beli vazelin, polisorbat 60, sorbitan stearat, glicerol, metilparahidroksibenzoat (E 218), propilparahidroksibenzoat (E 216), ksantanski gumi, prečiščena voda (glejte tudi poglavje 2 ‘'Zdravilo Zyclara vsebuje metilparahidroksibenzoat, propilparahidroksibenzoat, cetilalkohol, stearilalkohol in benzil alkohol'').
English: Imiquimod is an immune response modifier.
Slovenian: Farmakodinamični učinki Imikvimod je modulator imunskega odziva.
English: Application to broken skin could result in increased systemic absorption of imiquimod leading to a greater risk of adverse events (see section 4.8 and 4.9).
Slovenian: Nanašanje kreme na poškodovano kožo lahko privede do zvečanja sistemske absorpcije imikvimoda, kar lahko poveča tveganje za pojav neželenih učinkov (glejte poglavji 4.8 in Zaradi tveganja za večjo dovzetnost za sončne opekline se priporoča uporaba zaščitne sončne kreme,
English: Rare (≥ 1/10,000 to < 1/1,000);
Slovenian: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/1.000) in neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov)
English: Patients with hepatic or renal impairment were not included in clinical trials.
Slovenian: Bolniki z okvaro jeter ali ledvic niso bili vključeni v klinične študije.
English: Topical in vivo application of imiquimod cream on mouse skin resulted in increased concentrations of IFN and tumour necrosis factor (TNF) compared with skin of untreated mice.
Slovenian: V in vivo pogojih je lokalno nanašanje imikvimod kreme na kožo miši, v primerjavi s kožo nezdravljenih miši, povzročilo zvišanje koncentracij IFN in tumorje nekrotizirajočega faktorja
English: Very rare (<1/10,000) and not known (cannot be estimated from the available data)
Slovenian: Neznana pogostnost (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti)
English: Excipients: isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), xanthan gum, purified water.
Slovenian: Pomožne snovi: izostearinska kislina, benzilalkohol, cetilalkohol, stearilalkohol, beli vazelin, polisorbat 60, sorbitan stearat, glicerol, metilparahidroksibenzoat (E218), propilparahidroksibenzoat (E216), ksantanski gumi, prečiščena voda.
English: Talk to your doctor or pharmacist before using Zyclara:
Slovenian: Pred začetkom uporabe zdravila Zyclara se posvetujte z zdravnikom ali farmacevtom:
English: Patients had 5-20 typical visible or palpable AK lesions in an area that exceeded 25 cm2 on either the face or balding scalp.
Slovenian: Bolniki so imeli 5-20 klinično značilnih, vidnih ali otipljivih AK
English: Loughborough Leicester
Slovenian: Loughborough
English: Systemic exposure (percutaneous penetration) was calculated from recovery of carbon-14 from [14C] imiquimod in urine and faeces.
Slovenian: 14 [14C] iz imikvimoda v urinu in blatu.
English: This medicine may also cause flu-like symptoms (including tiredness, nausea, fever, muscle and joint pain, and shivering) before or during the occurrence of local skin reactions.
Slovenian: To zdravilo lahko pred pojavom lokalnih kožnih reakcij ali med njim povzroči tudi gripi podobne simptome (vključno z utrujenostjo, siljenjem na bruhanje, zvišano telesno temperaturo, bolečinami v mišicah in sklepih ter mrazenjem).
English: Haemoglobin decreased White blood cell count decreased Neutrophil count decreased Platelet count decreased
Slovenian: Bolezni krvi in limfatičnega sistema pogosti limfadenopatija neznana pogostnost znižan hemoglobin znižano število belih krvnih celic znižano število nevtofilcev znižano število trombocitov
English: Mylan Healthcare B.V. Krijgsman 20
Slovenian: Mylan Healthcare B.V.
English: No more than 2 sachets should be used per application.
Slovenian: Za en nanos lahko uporabite največ 2 vrečici.
English: Loughborough Leicestershire LE11 5SF, United Kingdom
Slovenian: LE11 5SF, Združeno kraljestvo (Velika Britanija)
English: Hands should be washed carefully before and after application of cream.
Slovenian: Pred vsakim nanašanjem kreme in po njem si je treba dobro umiti roke.
English: Contact with eyes, lips, and nostrils should be avoided.
Slovenian: Izogibati se je treba stiku z očmi, ustnicami in nosnicami.
English: Uncommon (may affect up to 1 in 100 people) - Changes at the application site, e.g. bleeding, small swollen areas in the skin, inflammation, pins and needles, increased sensitivity to touch, scarring, feeling of warmth, skin breakdown, blisters or pustules - Weakness - Shivering - Lack of energy (lethargy) - Discomfort - Swelling of the face - Back pain - Pain in limbs - Stuffy nose
Slovenian: - spremembe na mestu nanosa, npr. krvavitev, majhne otekline v koži, vnetje, mravljinčenje, povečana občutljivost na dotik, zabrazgotinjenje, občutek toplote, razpokanje kože, mehurčki ali pustule; - slabotnost, - drgetanje,
English: Following accidental ingestion, nausea, emesis, headache, myalgia and fever could occur after a single dose of 200 mg imiquimod which corresponds to the content of more than 21 sachets of Zyclara.
Slovenian: Po nenamernem zaužitju enkratnega odmerka 200 mg imikvimoda, kar ustreza vsebini več kot 21 vrečic zdravila Zyclara, se lahko pojavijo navzea, bruhanje, glavobol, mialgija in povišana telesna temperatura.
English: How to store Zyclara
Slovenian: Shranjevanje zdravila Zyclara
English: • Do not cover the treated area with bandages or other dressings after you have applied this medicine.
Slovenian: - Ne pokrivajte zdravljenega predela s povoji ali obvezami po nanosu tega zdravila.
English: Some systemic adverse reactions, including headache 6% (10/160), fatigue 4% (7/160), were reported by Zyclara treated patients in clinical trials.
Slovenian: Pri bolnikih, zdravljenih z zdravilom Zyclara v kliničnih študijah, so poročali o nekaterih sistemskih neželenih učinkih, vključno z glavobolom pri 6 % (10/160) in utrujenostjo pri 4 % (7/160).
English: The mean peak serum imiquimod concentration at the end of the pharmacokinetic study was 0.323 ng/mL.
Slovenian: Povprečna najvišja serumska koncentracija imikvimoda ob koncu farmakokinetične študije je bila
English: Hepatic enzyme increased
Slovenian: - povišane vrednosti jetrnih encimov
English: • Do not use more cream than your doctor has advised.
Slovenian: - Ne prekoračite priporočenega odmerka kreme.
English: Cutaneous use
Slovenian: dermalna uporaba
English: Zyclara 3.75% cream imiquimod
Slovenian: Zyclara 3,75 % krema imikvimod
English: Tumours occurred earlier and in greater number in the group of mice administered the vehicle cream in comparison with the low UVR control group.
Slovenian: V skupini mišk, ki so prejemale nosilec kreme, so se tumorji pojavljali bolj zgodaj in v večjem številu kot v kontrolni skupini, ki je bila manj obsevana.
English: Topical administration of imiquimod cream resulted in no tumour enhancement at any dose, in comparison with the vehicle cream group.
Slovenian: V primerjavi s skupino, ki je prejemala le vehikel, lokalna uporaba imikvimod kreme pri nobenem odmerku ni povzročila rasti tumorjev.
English: Very common (may affect more than 1 in 10 people) - Skin redness, scabbing, skin scaling, discharge, skin dryness, skin swelling, skin ulcer, and reduced skin pigmentation at the application site
Slovenian: - pordelost kože, nastanek krast, luščenje kože, izcedek, suha koža, otekline, razjede na koži in zmanjšana pigmentacija kože na mestu nanosa.
English: Depression Irritability
Slovenian: - omotičnost,
English: A different therapy is recommended if the treated lesion(s) show(s) insufficient response to Zyclara.
Slovenian: Če odziv lezij(-e) na zdravljenje z zdravilom Zyclara ni zadosten, se priporoča drugačno zdravljenje.
English: Rare cases of remote site dermatologic reactions, including erythema multiforme, have been reported from clinical trials with imiquimod 5% cream therapy.
Slovenian: V kliničnih preskušanjih imikvimod 5 % kreme so poročali o redkih primerih kožnih reakcij na oddaljenih mestih, vključno z multiformnim eritemom.
English: Anorexia Blood glucose increased
Slovenian: Presnovne in prehranske motnje pogosti anoreksija zvišana vrednost glukoze v krvi
English: Zyclara 3.75% cream Imiquimod Cutaneous use
Slovenian: Zyclara 3,75 % krema imikvimod dermalna uporaba
English: Application site dermatitis Application site bleeding Application site papules Application site paraesthesia Application site hyperaesthesia Application site inflammation Application site scar Application site skin breakdown Application site vesicles Application site warmth Asthenia
Slovenian: Splošne težave in spremembe na mestu aplikacije zelo pogosti eritem na mestu aplikacije nastajanje krast na mestu aplikacije luščenje na mestu aplikacije suhost na mestu aplikacije edem na mestu aplikacije razjeda na mestu aplikacije izcedek na mestu aplikacije pogosti reakcija na mestu aplikacije pruritus na mestu aplikacije bolečina na mestu aplikacije oteklina na mestu aplikacije pekoč občutek na mestu aplikacije draženje na mestu aplikacije izpuščaj na mestu aplikacije utrujenost pireksija gripi podobna bolezen bolečine bolečine v prsih občasni dermatitis na mestu aplikacije krvavitev na mestu aplikacije papule na mestu aplikacije parestezija na mestu aplikacije hiperstezija na mestu aplikacije vnetje na mestu aplikacije brazgotina na mestu aplikacije razpokanje kože na mestu aplikacije vezikli na mestu aplikacije občutek toplote na mestu aplikacije astenija mrazenje letargija neugodje vnetje
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE OF ADMINISTRATION
Slovenian: IME ZDRAVILA IN POT(I) UPORABE
English: Eye disorders
Slovenian: - draženje oči,
English: Back pain Pain in extremity
Slovenian: - bolečine v hrbtu, - bolečine v udih,
English: and rash - Swollen glands - Headache - Dizziness - Loss of appetite - Nausea - Diarrhoea - Vomiting - Flu-like symptoms - Fever - Pain - Muscle and joint pain - Chest pain - Insomnia - Tiredness - Viral infection (herpes simplex) - Increase in blood glucose
Slovenian: - izguba teka, - siljenje na bruhanje (navzea), - driska, - bruhanje, - gripi podobni simptomi, - zvišana telesna temperatura,
English: Once the discomfort stops you can resume your treatment schedule as recommended.
Slovenian: Ko težave prenehajo, lahko ponovno začnete z uporabo kreme po običajnem urniku.
English: Each treatment cycle should not be extended beyond 2 weeks due to missed doses or rest periods.
Slovenian: Posamezen ciklus zdravljenja zaradi pozabljenih odmerkov ali obdobij prekinitve ne sme biti daljši od 2 tednov.
English: Frequency not known (frequency cannot be estimated from the available data) - Changes in skin colour Some patients have experienced changes in skin colour in the area where Zyclara was applied.
Slovenian: - spremembe barve kože Pri nekaterih bolnikih je prišlo do sprememb barve kože na predelu, kjer je bila nanešena krema
English: Inflammation
Slovenian: Odmerjanje
English: The treatment starts with a daily application for two weeks, followed by a break without any application for two weeks, and then ends with a daily application again for two weeks.
Slovenian: Zdravljenje se nato zaključi z nanašanjem kreme enkrat na dan še nadaljnja dva tedna.
English: Zyclara should be applied once daily before bedtime to the skin of the affected treatment field (area) and remain on the skin for approximately 8 hours.
Slovenian: Zdravilo Zyclara se enkrat na dan pred spanjem nanese na kožo prizadetega predela, kjer naj ostane
English: • If the treated site becomes too uncomfortable, wash the cream off with mild soap and water.
Slovenian: - Če se na področju nanosa kreme pojavi neprijeten občutek, kremo sperite z blagim - milom in vodo.
English: Lethargy
Slovenian: Leicestershire
English: Medicinal product subject to medicinal prescription.
Slovenian: Predpisovanje in izdaja zdravila je le na recept.
English: 6.3 Shelf life
Slovenian: 3M Health Care Limited
English: Reductions in haemoglobin, white blood cell count, absolute neutrophils and platelets have been observed in clinical trials investigating the use of imiquimod 5% cream.
Slovenian: V kliničnih študijah uporabe imikvimod 5 % kreme so opazili znižanje vrednosti hemoglobina levkocitov, absolutnih nevtrofilcev in trombocitov.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS SACHET TEXT
Slovenian: PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH
English: The data described below reflect exposure to Zyclara or vehicle in 319 subjects enrolled in two double-blind studies.
Slovenian: 319 bolnikih, vključenih v dve dvojno slepi študiji.
English: Nausea Diarrhoea Vomiting
Slovenian: Bolezni živčevja pogosti glavobol omotica
English: Blood system disorders
Slovenian: Bolezni krvi
English: Immune system disorders
Slovenian: Bolezni imunskega sistema redki poslabšanje avtoimunskih bolezni
English: Headache Dizziness
Slovenian: - oteklina obraza,
English: Then contact your doctor or pharmacist.
Slovenian: Če ste negotovi, se posvetujte z zdravnikom ali farmacevtom.
English: Chills
Slovenian: Leicester
English: Imiquimod
Slovenian: OVOJNINAH
English: Pharmacodynamic effects
Slovenian: FARMAKOLOŠKE LASTNOSTI
English: Dry mouth Abdominal pain
Slovenian: Bolezni prebavil pogosti navzea diareja bruhanje občasni suha usta bolečina v trebuhu
English: Respiratory, thoracic and mediastinal disorders
Slovenian: Bolezni jeter, žolčnika in žolčevodov neznana pogostnost zvišane vrednosti jetrnih encimov
English: Nasal congestion Pharyngo laryngeal pain
Slovenian: Bolezni dihal, prsnega koša in mediastinalnega prostora občasni zamašen nos bolečine v faringo-laringealnem prostoru
English: Package leaflet: Information for the user Zyclara 3.75% cream
Slovenian: Navodilo za uporabo Zyclara 3,75 % krema imikvimod
English: Uncommon (≥ 1/1,000 to < 1/100);
Slovenian: Občasni (pojavijo se pri 1od 100 bolnikov)
English: The clinical significance of these results is not known.
Slovenian: Klinični pomen teh rezultatov ni znan.
English: In this study the majority of patients had a vital capacity less than 60%.
Slovenian: V tej študiji je imela večina bolnikov vitalno kapaciteto manj kot 60 %.
English: The mode of action is unclear.
Slovenian: Način delovanja ni jasen.
English: The recommended dose is one tablet, twice a day.
Slovenian: Priporočeni odmerek je ena tableta, dvakrat na dan.
English: The elimination half-life ranges from 9 to 15 hours.
Slovenian: Eliminacijski razpolovni čas je od 9 do 15 ur.
English: However, the power of this study to detect differences between treatment groups was low.
Slovenian: Vendar je bila moč te študije za odkrivanje razlik med skupinama majhna.
English: No significant increased benefit can be expected from higher daily doses.
Slovenian: Od večjih dnevnih odmerkov ni mogoče pričakovati pomembno večje koristi.
English: These increases could be associated with jaundice.
Slovenian: To zvišanje je lahko povezano z zlatenico.
English: If any of the above applies to you, or if you are not sure, tell your doctor who will decide what to do.
Slovenian: Če karkoli od navedenega velja za vas, ali če niste prepričani, povejte svojemu zdravniku, ki se bo odločil kaj storiti.
English: In case of overdose, treatment is symptomatic and supportive.
Slovenian: V primeru prevelikega odmerjanja je zdravljenje simptomatsko in podporno.
English: The volume of distribution of riluzole is about 245 ± 69 L (3.4 L/kg).
Slovenian: Volumen porazdelitve riluzola je približno 245 ± 69 l (3,4 l/kg).
English: If you forget to take your tablet, leave out that dose completely and take the next tablet at the usual time.
Slovenian: Če pozabite vzeti tableto, popolnoma izpustite ta odmerek in vzemite naslednjo tableto ob običajnem času.