FrancophonIA/ELRC3.0 huggingface dataset:
English: The age of these patients ranged from 3 months to 4 years and imatinib was given at dose 50 mg daily or doses ranging from 92.5 to 340 mg/m daily.
Croatian: Dob tih bolesnika bila je u rasponu od 3 mjeseca do 4 godine, a imatinib se primjenjivao u dozi od 50 mg na dan ili dozama u rasponu od 92,5 do 340 mg/m2
English: Plasma pharmacokinetics
Croatian: Farmakokinetika u plazmi
English: 5) Pleural effusion was reported more commonly in patients with GIST and in patients with transformed CML (CML-AP and CML-BC) than in patients with chronic CML.
Croatian: 5) Pleuralni izljev je češće zabilježen u bolesnika s GIST-om i u bolesnika s transformiranim KMLom (KML-ubrzana faza i KML-blastična kriza), nego u bolesnika s kroničnim KML-om.
English: In rats, hyperplasia of the transitional epithelium in the renal papilla and in the urinary bladder was observed at doses > 6 mg/kg in the 13-week study, without changes in serum or urinary parameters.
Croatian: U ispitivanju kod štakora koje je trajalo 13 tjedana zapažena je hiperplazija prijelaznog epitela u bubrežnoj papili te u mokraćnom mjehuru uz doze ≥6 mg/kg, bez promjena parametara za serum ili mokraću.
English: Packs containing 60 hard capsules.
Croatian: Pakiranja sadrže 60 tvrdih kapsula.
English: Concomitant use of imatinib and medicinal products that induce CYP3A4 (e.g. dexamethasone, phenytoin, carbamazepine, rifampicin, phenobarbital or Hypericum perforatum, also known as St. John's Wort) may significantly reduce exposure to imatinib, potentially increasing the risk of therapeutic failure.
Croatian: Istodobna primjena imatiniba i lijekova koji induciraju CYP3A4 (npr. deksametazon, fenitoin, karbamazepin, rifampicin, fenobarbital ili Hypericum perforatum, poznat također kao gospina trava) može značajno smanjiti izloženost imatinibu, što potencijalno povećava rizik od neuspjeha terapije.
English: Do not use this medicine after the expiry date which is stated on the blister and carton after EXP. Do not store above 30 °C.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na blisteru i kutiji iza kratice EXP/ „Rok valjanosti“.
English: Patients will be carefully checked by their doctor for signs of this infection before treatment is started.
Croatian: Prije početka liječenja liječnik će pažljvo pregledati bolesnike radi utvrđivanja eventualnih znakova te infekcije.
English: Posology for Ph+ ALL in adult patients
Croatian: Doziranje za Ph+ ALL u odraslih bolesnika
English: Palmoplantar erythrodysesthesia syndrome*, lichenoid keratosis*, lichen planus*, toxic epidermal necrolysis*, drug rash with eosinophilia and systemic symptoms
Croatian: Sindrom palmoplantarne eritrodisestezije*, lihenoidna keratoza*, lichen planus*, toksična epidermalna nekroliza*, osip uzrokovan lijekom s eozinofilijom i sistemskim simptomima (DRESS)* Poremećaji mišićno-koštanog sustava i vezivnog tkiva Vrlo često:
English: Patients with mild and moderate impairment of renal function appear to have a higher plasma exposure than patients with normal renal function.
Croatian: Izgleda da je plazmatska izloženost veća u bolesnika s blagim i umjerenim oštećenjem funkcije bubrega nego u bolesnika s normalnom funkcijom bubrega.
English: 1, sinusitis, cellulitis, upper respiratory tract infection, influenza, urinary tract infection, gastroenteritis, sepsis
Croatian: 1, sinusitis, celulitis, infekcija gornjih dišnih puteva, gripa, infekcija mokraćnog sustava,
English: Imatinib medac inhibits the growth of these cells.
Croatian: Imatinib medac inhibira rast ovih stanica.
English: Posology for CML in adult patients
Croatian: Doziranje za KML u odraslih bolesnika
English: Blast crisis is the most
Croatian: Blastična kriza predstavlja najuznapredovaliji stadij ove bolesti.
English: • Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph-positive ALL).
Croatian: • Akutne limfoblastične leukemije s pozitivnim Philadelphia kromosomom (Ph-pozitivni ALL).
English: The most commonly reported (≥ 10 %) treatment-related adverse reactions were mild nausea, vomiting, diarrhoea, abdominal pain, fatigue, myalgia, muscle cramps and rash.
Croatian: Najčešće zabilježene nuspojave (≥10 %) povezane s liječenjem, bile su blaga mučnina, povraćanje, proljev, bol u trbuhu, umor, bol u mišićima, grčevi u mišićima i osip.
English: The starting dose is 600 mg to be taken as 6 capsules of 100 mg (or 1 capsule of 400 mg plus 2 capsules of 100 mg) once a day.
Croatian: Početna doza iznosi 600 mg, a uzima se jednom na dan kao 6 kapsula od 100 mg (ili 1 kapsula od 400 mg i 2 kapsule od 100 mg).
English: Imatinib medac 400 mg hard capsules Each hard capsule contains 50.072 mg lactose monohydrate.
Croatian: Imatinib medac 400 mg tvrde kapsule Svaka tvrda kapsula sadrži 50,072 mg laktoze hidrata.
English: The paediatric patient received 400 mg/m2/daily, subsequently increased to 520 mg/m2/daily.
Croatian: Pedijatrijski bolesnici primali su 400 mg/m² na dan, kasnije je doza povećana na 520 mg/m² na dan.
English: 4) Flushing was most common in GIST patients and bleeding (haematoma, haemorrhage) was most common in patients with GIST and with transformed CML (CML-AP and CML-BC).
Croatian: Crvenilo uz osjećaj vrućine je bilo najčešće u bolesnika s GIST-om, a krvarenje (hematomi, hemoragija) je bilo najčešće u bolesnika s GIST-om i u bolesnika s transformiranim KML-om (KML-ubrzana faza i KML-blastična kriza).
English: Dose adjustments for neutropenia and thrombocytopenia:
Croatian: Prilagođavanje doze zbog neutropenije i trombocitopenije:
English: • Pale skin, feeling tired and breathlessness and having dark urine (signs of low levels of red
Croatian: • blijeda koža, umor i gubitak daha te tamno obojena mokraća (znakovi snižene razine crvenih krvnih stanica)
English: • Swelling such as round your ankles or puffy eyes.
Croatian: • oticanje kao što je oticanje gležnjeva ili otečene oči
English: Gynaecomastia, erectile dysfunction, menorrhagia, menstruation irregular, sexual dysfunction, nipple pain, breast enlargement, scrotal oedema
Croatian: Ginekomastija, erektilna disfunkcija, menoragija, nepravilne mjesečnice, poremećaj seksualne funkcije, bol u bradavicama, povećanje dojki, edem
English: 8) Some fatal cases of hepatic failure and of hepatic necrosis have been reported.
Croatian: 8) Zabilježeno je nekoliko smrtnih slučajeva zbog zatajenja jetre i nekroze jetre.
English: However if it is nearly time for the next
Croatian: Međutim, ako je uskoro vrijeme za sljedeću dozu, preskočite propuštenu dozu.
English: Eye irritation, eye pain, orbital oedema, scleral haemorrhage, retinal haemorrhage, blepharitis, macular oedema
Croatian: Iritacija oka, bol u oku, orbitalni edem, krvarenje bjeloočnice, krvarenje mrežnice, blefaritis, makularni edem
English: Flatulence, abdominal distension, gastro-oesophageal reflux, constipation, dry
Croatian: Flatulencija, abdominalna distenzija, gastroezofagealni refluks, konstipacija,
English: Metabolism and nutrition disorders
Croatian: Poremećaji metabolizma i prehrane Često:
English: Imatinib medac 100 mg hard capsules Each hard capsule contains 12.518 mg lactose monohydrate.
Croatian: Imatinib medac 100 mg tvrde kapsule Svaka tvrda kapsula sadrži 12,518 mg laktoze hidrata.
English: Packs containing 30 hard capsules.
Croatian: Pakiranja sadrže 30 tvrdih kapsula.
English: • Feeling light-headed, dizzy or fainting (signs of low blood pressure).
Croatian: • osjećaj da Vam se vrti u glavi, omaglica ili nesvjestica (znakovi sniženog krvnog tlaka)
English: • Feeling dizzy or weak.
Croatian: • omaglica ili slabost
English: Triple IT therapy (age-adjusted): days 1, 29
Croatian: Trostruka i.t. terapija (prilagođena dobi): dani 1, 29
English: Biochemistry
Croatian: Biokemija
English: Laboratory test abnormalities
Croatian: Abnormalne vrijednosti laboratorijskih testova
English: Imatinib medac is a treatment for adults and children and adolescents for:
Croatian: Imatinib medac se koristi kod odraslih osoba, djece i adolescenata za liječenje:
English: 9, arthralgia, bone
Croatian: 9, artralgiju,
English: • Severe abdominal pain, blood in your vomit, stools or urine, black stools (signs of
Croatian: • teška bol u trbuhu, krv u sadržaju povraćanja, stolici ili mokraći, crne stolice (znakovi probavnih problema)
English: The effectiveness of imatinib is based on overall haematological and cytogenetic response rates and progression-free survival.
Croatian: Klinička ispitivanja kod kronične mijeloične leukemije Učinkovitost imatiniba temelji se na općim hematološkim i citogenetskim stopama odgovora i preživljenju bez progresije.
English: What Imatinib medac contains
Croatian: Što Imatinib medac sadrži
English: Intensification block 2 (9 weeks)
Croatian: Intenzifikacijska terapija 2 (9 tjedana)
English: Constitutive activation of the PDGF receptor or the Abl protein tyrosine kinases as a consequence of fusion to diverse partner proteins or constitutive production of PDGF have been implicated in the pathogenesis of MDS/MPD, HES/CEL and DFSP.
Croatian: U patogenezu MDS/MPD-a, HES/KEL-a i DFSP-a uključena je ili konstitutivna aktivacija receptora za PDGF ili Abl protein-tirozin kinaza koja nastaje kao posljedica fuzije pri čemu se javljaju različiti partnerski proteini ili konstitutivno stvaranje PDGF-a.
English: The age of these patients ranged from 2 to 16 years and imatinib was given at dose 300 mg/m daily or doses ranging from 200 to 400 mg daily.
Croatian: Dob tih bolesnika bila je u rasponu od 2 do 16 godina, a imatinib se primjenjivao u dozi od 300 mg/m na dan ili u dozama u rasponu od 200 do 400 mg na dan.
English: Marketing Authorisation Holder medac
Croatian: Nositelj odobrenja za stavljanje lijeka u promet medac
English: Therapeutic indication
Croatian: Indukcijska terapija
English: The dose is 800 mg per day, to be taken as 1 capsule of 400 mg in the morning and 1 capsule of
Croatian: Doza je 800 mg na dan, a uzima se kao 1 kapsula od 400 mg ujutro i 1 kapsula od 400 mg navečer.
English: Intensification block 1 (9 weeks)
Croatian: Intenzifikacijska terapija 1 (9 tjedana)
English: Thrombocythaemia, lymphopenia, bone marrow depression, eosinophilia,
Croatian: Trombocitemija, limfopenija, depresija koštane srži, eozinofilija,
English: Positive genotoxic effects were obtained for imatinib in an in vitro mammalian cell assay (Chinese hamster ovary) for clastogenicity (chromosome aberration) in the presence of metabolic activation at a concentration of 125 μg/ml.Two intermediates of the manufacturing process, which are also present in the final product, are positive for mutagenesis in the Ames assay.
Croatian: Pozitivni su genotoksični učinci dobiveni za imatinib u in vitro testu na stanicama sisavca (jajnik kineskog hrčka) na klastogenost (aberacija kromosoma) u prisutnosti metaboličke aktivacije pri koncentracijama od 125 μg/ml.
English: How to store Imatinib medac
Croatian: Kako čuvati Imatinib medac
English: Triple IT therapy (age-adjusted): day 1
Croatian: Trostruka i.t. terapija (prilagođena dobi): dan 1
English: DEX 10 mg/m oral, days 1-5;
Croatian: DEX 10 mg/m² peroralno, dani 1-5;
English: DEX (6 mg/m2/day, PO): days 1-7 and 15-21
Croatian: DEX (6 mg/m²/dan, p.o.): dani 1-7 i 15-21
English: Hepatic function should be carefully monitored in circumstances where imatinib is combined with chemotherapy regimens also known to be associated with hepatic dysfunction (see section 4.5 and 4.8).
Croatian: U slučajevima kada se imatinib kombinira s režimima kemoterapije za koje je poznato da su povezani s poremećajem funkcije jetre, potrebno je pažljivo praćenje jetrene funkcije (vidjeti dijelove 4.5 i 4.8).
English: Isolated cases of imatinib overdose have been reported spontaneously and in the literature.
Croatian: Zabilježeni su spontani i literaturni izolirani slučajevi predoziranja imatinibom.
English: • Discharge from the eye with itching, redness and swelling (conjunctivitis), watery eyes or
Croatian: • iscjedak iz oka sa svrbežom, crvenilom ili oteklinom (konjunktivitis), suzne oči ili zamućen vid
English: Imatinib medac 100 mg hard capsules EU/1/13/876/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Imatinib medac 100 mg tvrde kapsule EU/1/13/876/001
English: Imatinib medac is also a treatment for children and adolescents with CML.
Croatian: Imatinib medac koristi se također za liječenje KML-a u djece i adolescenata.
English: The age of these patients ranged from newborn to 14 years and imatinib was given at dose 50 mg daily or doses ranging from 400 to 520 mg/m daily.
Croatian: Dob tih bolesnika bila je u rasponu od novorođenačke do 14 godina, a imatinib se primjenjivao u dozi od 50 mg na dan ili u dozama u rasponu od 400 do 520 mg/m na dan.
English: Posology for MDS/MPD in adult patients The recommended dose of imatinib is 400 mg/day for adult patients with MDS/MPD.
Croatian: Za odrasle bolesnike s MDS/MPD-om preporučena doza imatiniba iznosi 400 mg/dan.
English: Severe
Croatian: Teški
English: • Severely decreased urine output, feeling thirsty (signs of kidney problems).
Croatian: • jako smanjeno mokrenje, žeđ (znakovi bubrežnih problema)
English: Active substances that may decrease imatinib plasma concentrations Substances that are inducers of CYP3A4 activity (e.g. dexamethasone, phenytoin, carbamazepine, rifampicin, phenobarbital, fosphenytoin, primidone or Hypericum perforatum, also known as St. John's Wort) may significantly reduce exposure to imatinib, potentially increasing the risk of therapeutic failure.
Croatian: Djelatne tvari koje mogu smanjiti koncentracije imatiniba u plazmi Tvari koje induciraju djelovanje CYP3A4 (npr. deksametazon, fenitoin, karbamazepin, rifampicin, fenobarbital, fosfenitoin, primidon ili Hypericum perforatum, poznat također kao gospina trava) mogu značajno smanjiti izloženost imatinibu, čime se potencijalno povećava rizik od neuspjeha terapije.
English: CPM (300 mg/m2, IV): days 29-33
Croatian: CPM (300 mg/m², i.v.): dani 29-33
English: • Chronic renal failure.
Croatian: • kronično zatajenje bubrega.
English: 7, eructation, melaena, oesophagitis, ascites, gastric ulcer, haematemesis, cheilitis, dysphagia, pancreatitis
Croatian: 7, podrigivanje, melena, ezofagitis, ascites, želučani ulkus, hematemeza, heilitis, disfagija,
English: • Pain or swelling in your abdomen, flatulence, heartburn or constipation.
Croatian: • bol ili oticanje u trbuhu, vjetrovi, žgaravica ili zatvor
English: Skin and subcutaneous tissue disorders Very common: Periorbital oedema, dermatitis/eczema/rash
Croatian: Periorbitalni edem, dermatitis/ekcem/osip
English: Complete blood counts must be performed regularly during therapy with imatinib.
Croatian: Tijekom terapije imatinibom mora se redovito kontrolirati kompletna krvna slika.
English: The mechanism and relevance of these findings in the rat carcinogenicity study for humans are not yet clarified.
Croatian: Iz ovih nalaza studije kancerogenosti u štakora još nije razjašnjen mehanizam, kao ni važnost za ljude.
English: • Weight gain.
Croatian: • povećanje tjelesne težine.
English: Musculoskeletal and connective tissue disorders Very common: Muscle spasm and cramps, musculoskeletal pain including myalgia
Croatian: Spazam mišića i grčevi, mišićno-koštana bol uključujući mialgiju
English: 9/l, repeat step 1 and resume imatinib at reduced dose of 260 mg/m
Croatian: 9/l, treba ponoviti 1. korak i nastaviti primjenu imatiniba u smanjenoj dozi od 260 mg/m².
English: Methotrexate (5 g/m over 24 hours, IV): day 1 Leucovorin (75 mg/m at hour 36, IV; 15 mg/m
Croatian: Metotreksat (5 g/m² kroz 24 sata, i.v.): dan 1 Leucovorin (75 mg/m² u 36. satu, i.v.; 15 mg/m² i.v. ili p.o. svakih
English: Five (5) patients with MDS/MPD associated with PDGFR gene re-arrangements were reported in 4 publications.
Croatian: U 4 publikacije zabilježeno je pet (5) bolesnika s MDS/MPD-om povezanim s preraspodjelom gena za PDGFR.
English: DEX (6 mg/m 2/day, PO): days 1-5; 29-33
Croatian: DEX (6 mg/m/²dan, p.o.): dani 1-5; 29-33
English: VP-16 (100 mg/m2/day, IV): days 1-5
Croatian: VP-16 (100 mg/m²/dan, i.v.): dani 1-5
English: 9/l, repeat step 1 and resume imatinib at reduced dose of 400 mg.
Croatian: 9/l, treba ponoviti 1. korak i nastaviti primjenu imatiniba u smanjenoj dozi od 400 mg.
English: What Imatinib medac looks like and contents of the pack Imatinib medac 100 mg hard capsules are gelatin capsules of size “3” with orange body and cap. Imatinib medac 400 mg hard capsules are gelatin capsules of size “00” with caramel body and cap. Imatinib medac 100 mg capsules are supplied in packs containing 60 capsules in blisters.
Croatian: Kako Imatinib medac izgleda i sadržaj pakiranja Imatinib medac 100 mg tvrde kapsule želatinske su kapsule veličine “3”, s narančastim tijelom i kapicom.
English: Ifosfamide (1.8 g/m2/day, IV): days 1-5
Croatian: Ifosfamid (1,8 g/m²/dan, i.v.): dani 1-5
English: Consolidation block 2 (3 weeks)
Croatian: Konsolidacijska terapija 2 (3 tjedna)
English: Consolidation block 1 (3 weeks)
Croatian: Konsolidacijska terapija 1 (3 tjedna)
English: G-CSF (5 μg/kg, SC): days 4-13 or until ANC > 1500 post nadir
Croatian: G-CSF (5 μg/kg, s.c.): dani 5-14 ili do porasta ABN >1500 nakon
English: Clinical cases of hypothyroidism have been reported in thyroidectomy patients undergoing levothyroxine replacement during treatment with imatinib (see section 4.5).
Croatian: U bolesnika u kojih je obavljena tireoidektomija i koji primaju nadomjesnu terapiju levotiroksinom, zabilježeni su klinički slučajevi hipotireoze tijekom liječenja imatinibom (vidjeti dio 4.5).
English: • Feeling sick (nausea) with diarrhoea and vomiting, abdominal pain or fever (signs of bowel
Croatian: • mučnina s proljevom i povraćanjem, bol u trbuhu ili vrućica (znakovi crijevnih problema)
English: 9/l and platelets ≥ 75 x 10
Croatian: 9/l i trombociti ≥75 x 10 9/l.
English: CPM (250 mg/m2/dose q12h x 4 doses, IV): days 3 and 4
Croatian: CPM (250 mg/m²/doza svakih 12 sati x 4 doze, i.v.): dani 3 i 4 PEG-ASP (2500 IU/m², i.m.): dan 4
English: MTX 15 mg intrathecal, day 1;
Croatian: MTX 15 mg intratekalno, dan 1
English: Your doctor may decide to increase the dose to 400 mg, to be taken as 1 capsule of 400 mg once a day, depending on how you respond to treatment.
Croatian: Ovisno o tome kako reagirate na liječenje, liječnik može odlučiti povećati dozu do 400 mg, a uzima se kao 1 kapsula od 400 mg jednom na dan.
English: VP-16 (100 mg/m 2, IV): days 29-33
Croatian: VP-16 (100 mg/m², i.v.): dani 29-33
English: In GIST the investigational medicinal product was discontinued for imatinib-related adverse reactions in 4 % of patients.
Croatian: U ispitivanju GIST-a, primjena ispitivanog lijeka je prekinuta u 4 % bolesnika zbog nuspojava povezanih s primjenom imatiniba.
English: Posology for DFSP in adult patients The recommended dose of imatinib is 800 mg/day for patients with DFSP.
Croatian: Za bolesnike s DFSP-om preporučena doza imatiniba iznosi 800 mg/dan.
English: VCR 2 mg i.v., days 6, 13, 20; Daunorubicin 45 mg/m i.v., days 6-7, 13-14
Croatian: I DEX 10 mg/m² peroralno, dani 1-5; VCR 2 mg i.v., dani 6, 13, 20; daunorubicin 45 mg/m² i.v., dani 6-7, 13-14
English: Pleural effusion
Croatian: Oticanje zglobova
English: 9/l, repeat step 1 and resume imatinib at reduced dose of 300 mg.
Croatian: 9/l, treba ponoviti 1. korak i nastaviti primjenu imatiniba u smanjenoj dozi od 300 mg.
English: 9/l and/or platelets < 10 x 10
Croatian: 9/l i/ili trombociti <10 x 10
English: 9/l and/or platelets < 50 x 10
Croatian: 9/l i/ili trombociti <50 x 10
English: Five (5) patients with DFSP and PDGFR gene re-arrangements were reported in 3 publications.
Croatian: U 3 publikacije zabilježeno je pet (5) bolesnika s DFSP-om i preraspodjelom gena za PDGFR.
English: • Rash, red skin with blisters on the lips, eyes, skin or mouth, peeling skin, fever, raised red or purple skin patches, itching, burning sensation, pustular eruption (signs of skin problems).
Croatian: • osip, crvenilo kože s mjehurićima na usnama, očima, koži ili u ustima, ljuštenje kože, vrućica,
English: Three (3) patients with HES and CEL associated with PDGFR gene re-arrangements were reported in 3 publications.
Croatian: U 3 publikacije zabilježena su tri (3) bolesnika s HES-om i KEL-om povezanim s preraspodjelom gena za PDGFR.
English: Study AUS01
Croatian: Studija AJP01
English: Liver dysfunction
Croatian: Oštećenje funkcije bubrega
English: Imatinib medac 400 mg hard capsules Each hard capsule contains 400 mg of imatinib (as mesilate).
Croatian: Imatinib medac 400 mg tvrde kapsule Svaka tvrda kapsula sadrži 400 mg imatiniba (u obliku imatinibmesilata).
English: The capsule shell for 100 mg capsule is composed of gelatine, yellow iron oxide (E172), titanium dioxide (E171) and red iron oxide (E172).
Croatian: Ovojnica kapsule za kapsule od 100 mg sastoji se od želatine, žutog željezovog oksida (E172), titanijevog dioksida (E171) i crvenog željezovog oksida (E172).
English: Reinduction block 2 (3 weeks)
Croatian: Reindukcijska terapija 2 (3 tjedna)
English: Theaterstr.
Croatian: BROJ SERIJE
English: Very common: Headache Common:
Croatian: Poremećaji oka Često:
English: The capsule shell for 400 mg capsule is composed of gelatine, yellow iron oxide (E172), titanium dioxide (E171), red iron oxide (E172) and black iron oxide (E172).
Croatian: Ovojnica kapsule za kapsule od 400 mg sastoji se od želatine, žutog željezovog oksida (E172), titanijevog dioksida (E171), crvenog željezovog oksida (E172) i crnog željezovog oksida (E172).
English: The analysis confirmed that exposure of imatinib in paediatric patients receiving 260 mg/m once daily (not exceeding 400 mg once daily) or 340 mg/m once daily (not exceeding 600 mg once daily) were similar to those in adult patients who received imatinib 400 mg or 600 mg once daily.
Croatian: 400 mg jedanput na dan) ili 340 mg/m jedanput na dan (najviše 600 mg jedanput na dan) bila slična onoj u odraslih bolesnika koji su primali imatinib 400 mg ili 600 mg jedanput na dan.
English: • Joint pain with swelling.
Croatian: • bolovi u zglobovima s oticanjem
English: 9) Musculoskeletal pain during treatment with imatinib or after discontinuation has been observed in post-marketing
Croatian: 9) Nakon stavljanja lijeka u promet primijećena je mišićno-koštana bol koja se javlja tijekom liječenja imatinibom, kao i nakon prekida liječenja.
English: Evaluation by a cardiology specialist, performance of an echocardiogram and determination of serum troponin should therefore be considered in patients with HES/CEL, and in patients with MDS/MPD associated with high eosinophil levels before imatinib is administered.
Croatian: Prije primjene imatiniba u bolesnika s HES/KEL-om i u bolesnika s MDS/MPD-om povezanim s visokim razinama eozinofila potrebno je razmisliti o pregledu kod specijalista kardiologa, obavljanju ehokardiograma i određivanju serumskog troponina.
English: When and how to take Imatinib medac • Take Imatinib medac with a meal.
Croatian: Kada i kako uzimati Imatinib medac
English: 12 Gy in 8 fractions for all patients that are CNS1 and CNS2 at diagnosis 18 Gy in 10 fractions for patients that are CNS3 at diagnosis VCR (1.5 mg/m2/day, IV): days 1, 29
Croatian: Kranijalna iradijacija (samo blok br. 5) 12 Gy u 8 frakcija za sve bolesnike koji imaju CNS1 i CNS2 u trenutku dijagnoze
English: Consolidation therapy DEX 10 mg/m oral, days 1-5; Vindesine 3 mg/m i.v., day 1;
Croatian: DEX 10 mg/m² peroralno, dani 1-5; vindezin 3 mg/m² i.v., dan 1;
English: No patient developed grade 4 thrombocytopenia.
Croatian: Trombocitopenija 4. stupnja nije nastupila niti u jednog bolesnika.