FrancophonIA/ELRC3.0 huggingface dataset:
English: Combivir should not be taken with any other medicinal products containing lamivudine or medicinal products containing emtricitabine.
Croatian: Combivir se ne bi smio uzimati sa drugim lijekovima koji sadrže lamivudin ili emtricitabin.
English: Combivir is used to treat HIV (human immunodeficiency virus) infection in adults and children.
Croatian: Combivir je namijenjen liječenju infekcija HIV-om (virusom humane imunodeficijencije) u odraslih bolesnika i djece.
English: Combivir is indicated in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infection (see section 4.2).
Croatian: Combivir je indiciran u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje infekcije virusom humane imunodeficijencije (HIV) (vidjeti dio 4.2).
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited binding to the major plasma protein albumin (<36% serum albumin in vitro).
Croatian: Lamivudin pokazuje linearnu farmakokinetiku u rasponu terapijskih doza i ograničeno se veže za glavni protein u plazmi-albumin (<36% serumskog albumina in vitro).
English: Very rare : Aplastic anaemia
Croatian: Vrlo rijetko: aplastična anemija
English: Your doctor will decide if the active substances are suitable for you.
Croatian: Vaš liječnik će odlučiti da li je ovaj lijek pogodan za Vas.
English: • if you are seriously overweight (especially if you are a woman) Talk to your doctor if any of these apply to you.
Croatian: • ako ste ozbiljno pretili (posebice ako ste žena)
English: No Combivir dosage adjustment necessary, unless patient has renal impairment (See Section 4.2).
Croatian: Nije potrebno prilagođavanje doze Combivira, osim ako bolesnik ima oštećenje bubrega (vidjeti dio 4.2).
English: Rare : Insomnia, paraesthesiae, somnolence, loss of mental acuity, convulsions
Croatian: Rijetko: nesanica, parestezije, somnolencija, gubitak mentalne oštrine, konvulzije
English: If concomitant therapy with Combivir and any of these medicinal products is necessary then extra care should be taken in monitoring renal function and haematological parameters and, if required, the dosage of one or more agents should be reduced.
Croatian: Ako je istodobna terapija s Combivirom i bilo kojim od navedenih lijekova neophodna, potreban je poseban nadzor nad renalnom funkcijom i hematološkim parametrima, te ako je potrebno i smanjenje doze jednog ili više lijekova.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation:18 March 1998
Croatian: Datum prvog odobrenja: 18. ožujka 1998.
English: • if you have a very low red blood cell count (anaemia) or a very low white blood cell count (neutropenia).
Croatian: • ako imate vrlo nizak broj crvenih krvnih stanica (anemija) ili vrlo nizak broj bijelih krvnih stanica (neutropenija).
English: The likelihood of metabolic drug interactions with lamivudine is low due to the small extent of hepatic metabolism (5-10%) and low plasma binding.
Croatian: Vjerojatnost metaboličkih interakcija lamivudina s drugim lijekovima je vrlo mala zbog niskog opsega metabolizma u jetri (510%) i slabog vezanja za proteine plazme.
English: In six HIV-infected children from 2 to 13 years of age, zidovudine plasma pharmacokinetics were evaluated while subjects were receiving 120 mg/m2 zidovudine three times daily and again after switching to 180 mg/m2 twice daily.
Croatian: Farmakokinetika zidovudina ispitivana je u šestero djece inficirane virusom HIV-a, dobi od 2 do 13 godina, koja su primala zidovudin u dozi od 120 mg/m2 tri puta dnevno, te ponovo nakon promjene doze na 180 mg/m2 dvaput dnevno.
English: The median (range) lamivudine and zidovudine tmax values were 0.75 (0.50-2.00) hours and 0.50 (0.252.00) hours respectively.
Croatian: Medijan (raspon) tmax za lamivudin iznosio je 0,75 sata (0,50-2,00), a za zidovudin 0,50 sata (0,25-2,00).
English: The mean systemic clearance of lamivudine is approximately 0.32 l/h/kg, with predominantly renal clearance (>70%) via the organic cationic transport system.
Croatian: Prosječna vrijednost sistemskog klirensa lamivudina iznosi oko 0,32 l/h/kg, s predominantnim bubrežnim klirensom (>70%) putem organskog kationskog transportnog sistema.
English: Your doctor may need to monitor you while you are taking Combivir.
Croatian: Liječnik bi Vas trebao nadzirati dok uzimate
English: Dose reduction is required for patients with creatinine clearance ≤50 ml/min (see section 4.2).
Croatian: Preporuča se smanjenje doze lamivudina u bolesnika s klirensom kreatinina ≤50 ml/min (vidjeti dio 4.2).
English: Take special care with Combivir
Croatian: Budite posebno oprezni s Combivirom
English: Uncommon: Transient rises in liver enzymes (AST, ALT) Rare: Hepatitis
Croatian: Manje česte: prolazni porast jetrenih enzima (AST, ALT) Rijetke: hepatitis
English: Liver disease: If lamivudine is being used concomitantly for the treatment of HIV and HBV, additional information relating to the use of lamivudine in the treatment of hepatitis B infection is available in the Zeffix SmPC.
Croatian: Bolest jetre: Ako se lamivudin istodobno koristi za liječenje HIV i HBV infekcija, dodatne informacije o primjeni lamivudina u liječenju hepatitisa B dostupne su u Sažetku opisa svojstava lijeka za Zeffix.
English: Lamivudine-TP and zidovudine-TP have selective inhibitory activity against HIV-1 and HIV-2 replication in vitro; lamivudine is also active against zidovudine-resistant clinical isolates of HIV.
Croatian: Lamivudin-TP i zidovudinTP pokazuju selektivnu inhibicijsku aktivnost prema HIV-1 i HIV-2 replikaciji in vitro, a lamivudin djeluje i protiv kliničkog izolata HIV-a rezistentnog na zidovudin.
English: • tablet film-coat; hypromellose, titanium dioxide, macrogol 400 and polysorbate 80.
Croatian: • ovojnica tablete; hipromeloza, titanijev dioksid, makrogol 400, polisorbat 80.
English: Pancreatitis: Cases of pancreatitis have occurred rarely in patients treated with lamivudine and zidovudine.
Croatian: Pankreatitis: Rijetko su zabilježeni slučajevi pankreatitisa u bolesnika liječenih lamivudinom i zidovudinom.
English: Do not use this medicine after the expiry date which is stated on the carton.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na pakiranju iza oznake „ EXP“.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA
Croatian: 18. JEDNISTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM
English: If Combivir is discontinued in patients co-infected with hepatitis B virus, periodic monitoring of both liver function tests and markers of HBV replication for 4 months is recommended, as withdrawal of lamivudine may result in an acute exacerbation of hepatitis.
Croatian: Ako se ukida liječenje Combivirom u bolesnika istodobno zaraženih i hepatitis B virusom, preporučuje se periodičko praćenje testova jetrene funkcije i markera HBV replikacije tijekom 4 mjeseca, budući da prestanak uzimanja lamivudina može izazvati akutnu egzacerbaciju hepatitisa.
English: Two patterns of multi-drug resistance mutations, the first characterised by mutations in the HIV reverse transcriptase at codons 62, 75, 77, 116 and 151 and the second involving a T69S mutation plus a 6-base pair insert at the same position, result in phenotypic resistance to AZT as well as to the other approved NRTIs.
Croatian: reverzne transkriptaze na kodonima 62, 75, 77, 116 i 151, a druga uključuje mutaciju T69S uz umetanje 6-baznih parova na istom mjestu, što za posljedicu ima fenotipsku rezistenciju na AZT kao i na druge registrirane nukleozidne inhibitore reverzne transkriptaze.
English: The extent of lamivudine and zidovudine absorption (AUC∞) and estimates of half-life following administration of Combivir with food were similar when compared to fasting subjects, although the rates of absorption (Cmax, tmax) were slowed.
Croatian: (AUC∞) i procijenjeni poluvijek nakon primjene Combivira s hranom bili su slični vrijednostima dobivenima nakon primjene Combivira bolesnicima natašte, iako se brzina apsorpcije (Cmax,tmax) smanjila.
English: Some people taking Combivir or other combination treatments for HIV are more at risk of serious side effects.
Croatian: Pojedine osobe koje uzimaju Combivir ili drugu kombiniranu terapiju za HIV su pod višim rizikom od razvoja ozbiljnih nuspojava.
English: PHARMACEUTICAL FORM AND CONTENTS 60 film-coated tablets
Croatian: OBLIK I SADRŽAJ 60 filmom obloženih tableta Tablete s razdjelnim urezom
English: There is limited experience of overdosage with Combivir.
Croatian: Iskustvo s predoziranjem Combivirom je ograničeno.
English: • serious allergic reaction causing swelling of the face, tongue or throat which may cause difficulty in swallowing or breathing
Croatian: • ozbiljne alergijske reakcije koje uzrokuju oticanje lica, jezika ili grla što može dovesti do poteškoća u gutanju ili disanju • poremećaji jetre, kao što je žutica, povećana ili masna jetra, upala (hepatitis)
English: Therefore, maintaining lamivudine therapy despite emergence of M184V mutation should only be considered in cases where no other active NRTIs are available
Croatian: Stoga se nastavak terapije lamivudinom unatoč pojavi M184V mutacija treba razmotriti samo u slučajevima kada nisu dostupni drugi aktivni nukleozidni inhibitori reverzne transkriptaze.
English: Cssmax levels were 4.45 µM (1.19 µg/ml) following a dose of 120 mg zidovudine (in solution)/m2 body surface area and 7.7 µM (2.06 µg/ml) at 180 mg/m2 body surface area.
Croatian: Vrijednosti CSSmax su bile 4,45 μM (1,19 μg/ml) nakon primjene 120 mg zidovudina (u otopini)/m2 površine tijela, te 7,7 μM (2,06 μg/ml) nakon doze od 180 mg/m2 površine tijela.
English: In vitro data tend to suggest that the continuation of lamivudine in antiretroviral regimen despite the development of M184V might provide residual antiretroviral activity (likely through impaired viral fitness).
Croatian: Rezultati testova in vitro sugeriraju da nastavak primjene lamivudina u antivirusnom liječenju unatoč razvoju M184V može osigurati ostatnu antiretrovirusnu aktivnost (najvjerojatnije putem smanjenog infektivnog virusnog potencijala).
English: Zidovudine is contraindicated in patients with abnormally low neutrophil counts (<0.75 x 109/l), or abnormally low haemoglobin levels (<7.5 g/dl or 4.65 mmol/l).
Croatian: Zidovudin je kontraindiciran u bolesnika s izrazito niskim brojem neutrofila (<0,75 x 109/l), ili s izrazito niskom razinom hemoglobina (<7,5 g/dl ili 4,65 mmol/l).
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine nuspojave su navedene od ozbiljnijih prema manje ozbiljnim.
English: M184V mutants display greatly reduced susceptibility to lamivudine and show diminished viral replicative capacity in vitro.
Croatian: Mutante M184V imaju znatno smanjenu osjetljivost na lamivudin i umanjeni kapacitet replikacije virusa in vitro.
English: Cartons containing white high density polyethylene (HDPE) bottle with a child-resistant closure.
Croatian: Kartonska kutija sadrži bijelu bocu od polietilena visoke gustoće (HDPE) sa sigurnosnim zatvaračem za djecu.
English: For situations where discontinuation of therapy with one of the active substances of Combivir, or dose reduction is necessary separate preparations of lamivudine and zidovudine are available in tablets/capsules and oral solution.
Croatian: U slučajevima kada je potrebno ukinuti liječenje jednim od djelatnih tvari Combivira, ili ako je potrebno smanjiti dozu, moguće je liječenje odvojenim pripravcima lamivudina i zidovudina, koji su dostupni u obliku tableta/kapsula i oralne otopine.
English: Nervous system disorders Common: Headache, insomnia Very rare: Peripheral neuropathy (or paraesthesiae)
Croatian: Često: glavobolja, nesanica Vrlo rijetko: periferna neuropatija (ili parestezije)
English: Lamivudine at a dose of 100 mg once daily has also been shown to be effective for the treatment of adult patients with chronic HBV infection (for details of clinical studies, see the prescribing information for Zeffix).
Croatian: Lamivudin u dozi od 100 mg jedanput na dan pokazao se djelotvornim i u liječenju odraslih bolesnika s kroničnom hepatitis B infekcijom (za detalje pogledajte Sažetak opisa svojstava lijeka Zeffix).
English: INFORMATION IN BRAILLE combivir
Croatian: 16. PODACI NA BRAILLEOVOM PISMU combivir
English: When such development is found, treatment with Combivir should not be continued (see section 4.4).
Croatian: Kad se takav razvoj otkrije, ne smije se nastaviti liječenje lijekovima Combivir/Trizivir (vidjeti dio 4.4).
English: Dosages of 180 mg/m2 four times daily in children produced similar systemic exposure (24 hour AUC 40.0 h µM or 10.7 h µg/ml) as doses of 200 mg six times daily in adults (40.7 h µM or 10.9 h µg/ml).
Croatian: Lijek primijenjen u djece u dozi od 180 mg/m2 četiri puta dnevno imao je sličnu sistemsku izloženost (24-satna ukupna bioraspoloživost AUC 40,0 h μM ili 10,7 h μg/ml), kao i doza od 200 mg šest puta dnevno primijenjene u odraslih
English: Subjects receiving lamivudine and zidovudine with or without additional concomitant antiretroviral therapies and who already present with the M184V mutant virus also experience a delay in the onset of mutations that confer resistance to zidovudine and stavudine (Thymidine Analogue Mutations; TAMs).
Croatian: bolesnika koji se liječe lamivudinom i zidovudinom sa ili bez drugih antiretrovirusnih lijekova, a u kojih je već prisutan mutant virusa M184V, mutacije koje uzrokuju rezistenciju na zidovudin i stavudin također nastupaju kasnije (mutacije analoga timidina).
English: Both of these belong to a group of antiretroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Croatian: One pripadaju skupini antiretrovirusnih lijekova, nazvanih nukleozidnim inhibitorima reverzne transkriptaze (NRTI).
English: Renal clearance of zidovudine is estimated to be 0.34 l/h/kg, indicating glomerular filtration and active tubular secretion by the kidneys.
Croatian: Renalni klirens zidovudina procijenjen je na 0,34 l/h/kg, ukazujući na pretežno izlučivanje glomerularnom filtracijom i aktivnom tubularnom sekrecijom.
English: In vitro antagonism of anti-HIV activity between stavudine and zidovudine could result in decreased efficacy of both drugs.
Croatian: aktivnosti između stavudina i zidovudina može rezultirati sniženom djelotvornosti za oba lijeka
English: White to off-white, capsule-shaped film-coated scored tablets engraved with “GXFC3” on both sides.
Croatian: Bijele do gotovo bijele filmom obložene tablete oblika kapsule s razdjelnim urezom i utisnutim natpisom „GXFC3” na obje strane.
English: For children who weigh less than 14 kg lamivudine and zidovudine (the ingredients of Combivir) should be taken separately.
Croatian: Za djecu s tjelesnom težinom manjom od 14 kg, preporučuje se odvojeno uzimanje lamivudina i zidovudina (sastojaka Combivira) kao zasebnih pripravaka.
English: Abacavir maintains its antiretroviral activities against lamivudineresistant HIV-1 harbouring only the M184V mutation.
Croatian: Abakavir održava antiretrovirusno djelovanje protiv HIV-1 rezistentnih na lamivudin koji imaju samo mutaciju M184V.
English: It allows continued monitoring of the benefit/risk balance of the medicinal product.
Croatian: Time se omogućuje kontinuirano praćenje omjera koristi i rizika primjene lijeka.
English: Zidovudine and stavudine maintain their antiretroviral activities against lamivudine-resistant HIV-1.
Croatian: Zidovudin i stavudin održavaju antiretrovirusno djelovanje protiv HIV-1 rezistentnih na lamivudin.
English: When possible, avoid chronic coadministration of Combivir with medicinal products containing sorbitol or other osmotic acting poly-alcohols or monosaccharide alcohols (e.g. xylitol, mannitol, lactitol, maltitol).
Croatian: Kada je moguće, izbjegavajte dugotrajnu istodobnu primjenu Combivira i lijekova koji sadrže sorbitol ili neki drugi polialkohol ili monosaharidni alkohol s osmotskim djelovanjem (npr. ksilitol, manitol, laktitol,
English: Combivir may be administered with or without food.
Croatian: Combivir se može uzimati sa ili bez hrane.
English: In oral carcinogenicity studies with zidovudine in mice and rats, late appearing vaginal epithelial tumours were observed.
Croatian: U ispitivanjima kancerogenosti peroralne uporabe zidovudina na miševima i štakorima opažena je kasna pojava tumora vaginalnog epitela.
English: Dosage adjustments in patients with haematological adverse reactions: Dosage adjustment of zidovudine may be necessary if the haemoglobin level falls below 9 g/dl or 5.59 mmol/l or the neutrophil count falls below 1.0 x 109/l (see sections 4.3 and 4.4).
Croatian: Prilagodbe doze u bolesnika s nuspojavama hematološkog sustava: Može biti potrebna prilagodba doze zidovudina ako razina hemoglobina padne ispod 9 g/dl ili 5,59 mmol/l, ili broj neutrofila padne ispod 1,0 x 109/l (vidjeti dijelove 4.3 i 4.4).
English: Additionally dosage adjustment of zidovudine may be required if severe anaemia or myelosuppression occurs during treatment with Combivir, or in patients with pre-existing bone marrow compromise e.g. haemoglobin <9 g/dl (5.59 mmol/l) or neutrophil count <1.0 x 109/l (see section 4.2).
Croatian: Mogu biti potrebne dodatne prilagodbe doziranja zidovudina u slučaju pojave teške anemije ili mijelosupresije za vrijeme liječenja s Combivirom, ili u bolesnika s postojećom bolesti koštane srži, tj. hemoglobin <9 g/dl (5,59 mmol/l) ili broj neutrofila <1,0 x 109/l (vidjeti dio 4.2).
English: These occurred more frequently at higher dosages (1200-1500 mg/day) and in patients with advanced HIV disease (especially when there is poor bone marrow reserve prior to treatment), and particularly in patients with CD4 cell counts less than 100/mm3 (see section 4.4).
Croatian: (1200-1500 mg/dan), kao i u bolesnika s uznapredovalom HIV bolesti (posebice kada je rezerva koštane srži bila slaba i prije početka liječenja), a naročito u bolesnika s brojem CD4 stanica <100/mm3 (vidjeti dio 4.4).
English: • indigestion, taste disturbance
Croatian: • loša probava, smetnje vezane za okus
English: Evidence from clinical studies shows that lamivudine plus zidovudine delays the emergence of zidovudine resistant isolates in individuals with no prior antiretroviral therapy.
Croatian: U kliničkim ispitivanjima je dokazano da kombinacija lamivudina i zidovudina odgađa pojavu zidovudin-rezistentnih izolata u osoba koje ranije nisu dobivale nikakvu antiretrovirusnu terapiju.
English: Psychiatric disorders Rare: Anxiety and depression
Croatian: Rijetko: anksioznost i depresija
English: • tablet core; microcrystalline cellulose, sodium starch glycollate (gluten free), magnesium stearate, colloidal silicon dioxide
Croatian: • jezgra tablete; mikrokristalična celuloza, natrijev škroboglikolat (bez glutena), magnezijev stearat, koloidni silicijev dioksid
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 150 mg lamivudine and 300 mg zidovudine.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Jedna filmom obložena tableta sadrži 150 mg lamivudina i 300 mg zidovudina.
English: It is important to read the information later in this section under ‘Other possible side effects of combination therapy for HIV'.
Croatian: Vrlo je važno pročitati informacije u dijelu “Ostale moguće nuspojave u kombiniranoj terapiji za
English: In general, lamivudine pharmacokinetics in paediatric patients are similar to adults.
Croatian: Farmakokinetika lamivudina u pedijatrijskih bolesnika i odraslih je podjednaka.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Ova uputa je zadnji puta revidirana u {MM/GGGG} Detaljne informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: Pharmacotherapeutic group: Antivirals for treatment of HIV infections, combinations, ATC Code: J05AR01
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: Antivirotici za liječenje HIV infekcije, kombinacije, ATK oznaka:
English: For patients co-infected with hepatitis who are being treated with lamivudine containing medicinal products such as Combivir and subsequently become pregnant, consideration should be given to the possibility of a recurrence of hepatitis on discontinuation of lamivudine.
Croatian: Za bolesnice s ko-infekcijom virusom hepatitisa, a koje su liječene s lijekovima koji sadržavaju lamivudin, kao što je i Combivir te u međuvremenu ostanu trudne, mora se razmotriti mogućnost recidiva hepatitisa prilikom obustave terapije lamivudinom.
English: Combivir can make you dizzy and have other side effects that make you less alert.
Croatian: Od Combivira možete osjećati omaglicu ili druge nuspojave koje Vam mogu smanjiti pažnju.
English: The mean ratios of CSF/serum lamivudine and zidovudine concentrations 2-4 hours after oral administration were approximately 0.12 and 0.5 respectively.
Croatian: Srednji omjer koncentracija lamivudina u likvoru i serumu 2-4 sata nakon oralne primjene iznosi oko 0,12, a zidovudina 0,5.
English: These may affect up to 1 in 1000 people:
Croatian: Mogu se pojaviti u manje od 1 na 1000 osoba:
English: Lamivudine and zidovudine have been widely used as components of antiretroviral combination therapy with other antiretroviral agents of the same class (NRTIs) or different classes (PIs, nonnucleoside reverse transcriptase inhibitors).
Croatian: Lamivudin i zidovudin se široko primjenjuju kao komponente u kombiniranoj antiretrovirusnoj terapiji s drugim antiretrovirusnim lijekovima iste skupine (nukleozidni inhibitori reverzne transkriptaze) ili drugih skupina (inhibitori proteaze, nenukleozidni inhibitori reverzne transkriptaze).
English: SPECIAL STORAGE CONDITIONS Do not store above 30°C
Croatian: POSEBNE MJERE ČUVANJA Ne čuvati na temperaturi iznad 30oC.
English: Children weighing between 21 kg and 30 kg: the recommended oral dose of Combivir is one-half tablet taken in the morning and one whole tablet taken in the evening.
Croatian: Djeca s tjelesnom težinom između 21 kg i 30 kg: preporučena oralna doza Combivira je pola tablete ujutro i jedna cijela tableta navečer.
English: Multiple drug antiretroviral therapy containing lamivudine has been shown to be effective in antiretrovirally-naive patients as well as in patients presenting with viruses containing the M184V mutations.
Croatian: Kombinirana antiretrovirusna terapija koja sadrži lamivudin pokazala se djelotvornom u bolesnika koji prethodno nisu primali antiretrovirusne lijekove kao i u bolesnika kojima su izolirani virusi s mutacijama M184V.
English: People with advanced HIV infection (AIDS) have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Croatian: Stare infekcije mogu se ponovno javiti Bolesnici s uznapredovalom HIV infekcijom (SIDA) imaju oslabljen imunološki sustav, te su skloniji razvoju ozbiljnih infekcija (oportunističkih infekcija).
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati Combivir Lijek čuvajte izvan pogleda i dohvata djece.
English: The usual starting dose of Combivir is one half tablet (½) taken in the morning and one whole tablet taken in the evening.
Croatian: Uobičajena početna doza Combivira je pola (½) tablete ujutro, a jedna cijela tableta navečer.
English: Methadone/Zidovudine (30 to 90 mg once daily/200 mg every 4 hours)
Croatian: metadon/zidovudin (30 do 90 mg jedanput dnevno/ 200 mg svakih 4 sata )
English: Adults and adolescents weighing at least 30 kg: the recommended dose of Combivir is one tablet twice daily.
Croatian: Odrasli i adolescenti tjelesne težine najmanje 30 kg: preporučena doza Combivira je jedna tableta dva puta dnevno.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING BLISTER PACK OUTER CARTON
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU BLISTER PAKIRANJE, KUTIJA
English: What you need to know before you take Combivir
Croatian: Što morate znati prije nego počnete uzimati Combivir Nemojte uzimati Combivir: