FrancophonIA/ELRC3.0 huggingface dataset:
English: • If you have missed two or more doses talk to your doctor as you may need to restart Intuniv with a lower dose.
Croatian: Ako ste propustili dvije ili više doza, obratite se svom liječniku jer možda ćete trebati ponovo započeti uzimati Intuniv pri nižoj dozi.
English: Adult patients Intuniv has not been studied in adults with ADHD.
Croatian: Odrasli bolesnici Intuniv nije ispitan u odraslih s ADHD-om.
English: Immediate-release guanfacine tablets should not be substituted on a mg/mg basis, because of differing pharmacokinetic profiles.
Croatian: Tablete gvanfacina s trenutnim oslobađanjem ne smiju se zamijeniti po principu mg za mg zbog različitog farmakokinetičkog profila.
English: • your response to treatment, in particular if it makes you sleepy or drowsy
Croatian: • Vaš odgovor na liječenje, osobito ako ste zbog lijeka pospani ili omamljeni
English: A decision must be made whether to discontinue breast-feeding or to discontinue and/or abstain from Intuniv therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je odlučiti da li prekinuti dojenje ili prekinuti liječenje/suzdržati se od liječenja lijekom Intuniv uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: The clinical relevance is unknown.
Croatian: Klinička važnost nije poznata.
English: Due to lack of proper toxicokinetic data, comparison to human clinical exposure was not possible.
Croatian: Zbog nedostatka pravih toksikokinetičkih podataka nije bilo moguće napraviti usporedbu s kliničkom izloženošću u ljudi.
English: Very rare
Croatian: Malaksalost rijetko
English: By stimulating alpha 2A-adrenergic receptors, guanfacine reduces sympathetic nerve impulses from the vasomotor centre to the heart and blood vessels.
Croatian: Stimulirajući alfa2A-adrenergičke receptore, gvanfacin smanjuje impulse simpatičkih živaca iz vazomotornog centra do srca i krvnih žila.
English: Length of treatment
Croatian: Trajanje liječenja
English: ADHD with Oppositional Symptoms Study
Croatian: Ispitivanje ADHD-a s opozicijskim ponašanjem
English: Difference from placebo (95%CI) Effect size
Croatian: Razlika u odnosu na placebo (95% CI) Veličina učinka
English: While you are taking this medicine your doctor will repeat these checks weekly during initial dosing, after dose adjustments, at least every 3 months for the first year and then at least twice a year.
Croatian: Dok uzimate ovaj lijek, liječnik će te pretrage provoditi svakog tjedna na početku liječenja, nakon prilagodbe doze najmanje svaka 3 mjeseca tijekom prve godine, a potom najmanje dvaput godišnje.
English: This finding has no known clinical relevance.
Croatian: Ovaj nalaz nema poznatu kliničku važnost.
English: Patients/caregivers should be instructed not to discontinue guanfacine without consulting their physician.
Croatian: Bolesnike/skrbnike treba upozoriti da ne prekinu primjenu gvanfacina bez prethodnog savjetovanja s liječnikom.
English: Depending on the patient's response and tolerability for Intuniv the recommended maintenance dose range is 0.05-0.12 mg/kg/day.
Croatian: Ovisno o bolesnikovu odgovoru i podnošljivosti Intuniva, raspon preporučene doze održavanja iznosi 0,05-0,12 mg/kg na dan.
English: • weight increase/risk of obesity
Croatian: • povećanja tjelesne težine/rizika od pretilosti
English: Dose Titration Schedule for Children Aged 6-12 years
Croatian: Raspored titriranja doze za djecu u dobi od 6 do 12 godina Skupina po težini
English: The increases in blood pressure were observed in some individuals at the end of the follow up period which ranged between 3 and 26 weeks post final dose (see sections 4.2 and 5.1).
Croatian: Porast krvnog tlaka opažen je u nekih osoba na kraju razdoblja praćenja koje je variralo između 3 i 26 tjedana nakon zadnje doze (vidjeti dijelove 4.2 i 5.1).
English: • Do not take this medicine with fatty foods (e.g., high fat breakfast), as it may affect the way this medicine works.
Croatian: • Nemojte uzimati ovaj lijek s masnom hranom (npr. doručak s visokim udjelom masti), jer to može utjecati na način na koji ovaj lijek djeluje.
English: The tablets come in pack sizes of 7, 28 or 84 but not all pack sizes may be available.
Croatian: Tablete dolaze u pakiranjima od 7, 28 ili 84 tablete, ali ne moraju sve veličine pakiranja biti dostupne.
English: Your doctor may increase your dose based on your body weight and how Intuniv is working for you but not by more than 1 mg per week.
Croatian: Liječnik Vam može povisiti dozu na temelju tjelesne težine i djelovanja Intuniva na Vas, ali za najviše 1 mg tjedno.
English: Do not stop taking this medicine without first talking to your doctor.
Croatian: Nemojte prestati uzimati ovaj lijek bez da prethodno o tome niste razgovarali s liječnikom.
English: • Checklist prior to initiating treatment with Intuniv to identify patients at risk for serious undesirable effects
Croatian: • kontrolna lista prije početka liječenja Intunivom kako bi se prepoznali bolesnici u kojih postoji rizik od ozbiljnih nuspojava
English: Sedation and somnolence
Croatian: Sedacija i somnolencija
English: The MAH shall ensure that, following discussions and agreement with the National Competent Authorities in each Member State where Intuniv is launched all healthcare professionals who are expected to prescribe Intuniv are informed through an information letter on having access to / are provided with the following items:
Croatian: Nakon rasprava i dogovora s nacionalnim nadležnim tijelom u svakoj državi članici u kojoj je Intuniv pušten u promet, nositelj odobrenja osigurat će da svi zdravstveni radnici za koje se očekuje da će propisivati Intuniv budu obaviješteni putem obavijesnog pisma da imaju pristup sljedećem materijalu / dobiju sljedeće materijale:
English: For all patients, the recommended starting dose is 1 mg of guanfacine, taken orally once a day.
Croatian: Za sve je bolesnike preporučena početna doza 1 mg gvanfacina koja se uzima peroralno jedanput na dan.
English: Intuniv can cause dizziness and somnolence.
Croatian: Intuniv može uzrokovati omaglicu i somnolenciju.
English: Guanfacine is a selective alpha2A-adrenergic receptor agonist in that it has 15-20 times higher affinity for this receptor subtype than for the alpha2B or alpha2C subtypes.
Croatian: Gvanfacin je selektivni agonist alfa2A-adrenergičkih receptora i ima 15-20 puta veći afinitet prema ovoj podvrsti receptora nego prema podvrstama alfa2B ili alfa2C.
English: There is no evidence of any impact of ethnicity on the pharmacokinetics of Intuniv.
Croatian: Nema dokaza da etnicitet na bilo koji način utječe na farmakokinetiku Intuniva.
English: Guanfacine is an in vitro inhibitor of MATE1 and the clinical relevance of MATE1 inhibition cannot be excluded.
Croatian: Gvanfacin je in vitro inhibitor MATE1 i ne može se isključiti klinički značaj inhibicije MATE1.
English: If somnolence and sedation are judged to be clinically concerning or persistent, a dose decrease or discontinuation should be considered.
Croatian: Ako se prosudi da su somnolencija i sedacija klinički zabrinjavajući ili uporno prisutni, potrebno je razmotriti sniženje doze ili prekid liječenja.
English: The recommended dose is between 0.05 up to 0.12 mg per kg of bodyweight per day.
Croatian: Preporučena doza je od 0,05 do 0,12 mg po kg tjelesne težine na dan.
English: • Do not breast-feed while taking Intuniv unless told to do so by your doctor.
Croatian: • Nemojte dojiti dok uzimate Intuniv osim ako Vam je to rekao liječnik.
English: Guanfacine showed embryo foetal developmental toxicity in mice and rats (NOAEL 0.5 mg/kg/day) and in rabbits (NOAEL 3.0 mg/kg/day) in the presence of maternal toxicity.
Croatian: Gvanfacin je pokazao embriofetalnu razvojnu toksičnost u miševa i štakora (NOAEL 0,5 mg/kg na dan) i kunića (NOAEL 3,0 mg/kg na dan) u prisutnosti toksičnosti za majku.
English: Haemodynamic instability has also been associated with a guanfacine overdose 3 times the recommended daily dose.
Croatian: Hemodinamska nestabilnost također je povezana s predoziranjem gvanfacinom u dozi 3 puta većoj od preporučene dnevne doze.
English: Dose adjustments (increase or decrease) to a maximum tolerated dose within the recommended optimal weight-adjusted dose range based upon clinical judgement of response and tolerability may occur at any weekly interval after the initial dose.
Croatian: Prilagodbe doze (povišenje ili sniženje) na maksimalnu podnošljivu dozu unutar preporučenog optimalnog raspona doza prilagođenih tjelesnoj težini na temelju kliničke prosudbe odgovora i podnošljivosti, može se provesti u bilo kojem tjednom intervalu nakon početne doze.
English: It is not known if Intuniv will affect your unborn baby.
Croatian: Intuniv utjecati na Vaše nerođeno dijete.
English: These effects occur predominantly at the start of treatment and may occur less frequently as treatment continues.
Croatian: Ovi učinci nastaju pretežno na početku liječenja i mogu se manje često javljati u nastavku liječenja.
English: • Checklist for ongoing monitoring and safety management of patients including titration phase during treatment with Intuniv
Croatian: • kontrolna lista za trajno praćenje i upravljanje sigurnošću bolesnika uključujući fazu titracije tijekom liječenja Intunivom
English: Furthermore, based on in vitro studies, guanfacine may be an inhibitor of OCT1 at maximal portal vein concentrations.
Croatian: Nadalje, na temelju ispitivanja in vitro, gvanfacin može biti inhibitor OCT1 pri maksimalnim koncentracijama u portalnoj veni.
English: Guanfacine is a known antihypertensive agent.
Croatian: Gvanfacin je poznati antihipertenzivni lijek.
English: This results in a decrease in peripheral vascular resistance and blood pressure, and a reduction in heart rate.
Croatian: To dovodi do smanjenja periferne vaskularne rezistencije i sniženja krvnog tlaka, kao i do smanjenja srčane frekvencije.
English: The mechanism of this interaction is unknown, although both guanfacine and valproic acid are metabolised by glucuronidation, possibly resulting in competitive inhibition.
Croatian: Mehanizam ove interakcije nije poznat, iako se i gvanfacin i valproatna kiselina metaboliziraju glukuronidacijom pa postoji mogućnost kompetitivne inhibicije.
English: The ADHD Rating Scale is a measure of the core symptoms of ADHD.
Croatian: Ljestvicom procjene ADHD-a mjere se glavni simptomi ADHD-a.
English: What Intuniv is and what it is used for
Croatian: Što je Intuniv i za što se koristi
English: The effect of co-administration with psychostimulants was examined in an add-on study in partial responders to psychostimulants.
Croatian: Učinak istovremene primjene s psihostimulansima bio je provjeren u ispitivanju dodatne terapije u osoba s djelomičnim odgovorom na psihostimulanse.
English: Intuniv should not be administered with high fat meals due to increased exposure, as it has been shown that high fat meals have a significant effect on the absorption of guanfacine.
Croatian: Intuniv se ne smije primjenjivati s obrocima s visokim udjelom masti zbog povećanja izloženosti jer se pokazalo da obroci s visokim udjelom masti značajno utječu na apsorpciju gvanfacina.
English: No age differences were observed with respect to response to the ADHD-RS-IV.
Croatian: Nisu opažene dobne razlike s obzirom na odgovor na ljestvici ADHD-RS-IV.
English: Not known
Croatian: Nije poznato hoće li
English: In the event of a missed dose, Intuniv dosing can resume the next day.
Croatian: U slučaju da se propusti doza, s uzimanjem doze Intuniva može se nastaviti sljedećeg dana.
English: Formal pharmacokinetic studies for race have not been conducted.
Croatian: Nisu provedena službena farmakokinetička ispitivanja utjecaja rase.
English: Guanfacine is moderately bound to plasma proteins (approximately 70%), independent of drug concentration.
Croatian: Distribucija Gvanfacin se umjereno veže za proteine plazme (približno 70%), neovisno o koncentraciji lijeka.
English: • you have low or high blood pressure, heart problems or have a family history of heart problems
Croatian: • ako imate niski ili visoki krvni tlak, tegobe sa srcem ili je netko u obitelji imao tegobe sa srcem
English: Co-administration with Psychostimulants
Croatian: Istovremena primjena s psihostimulansima
English: Intuniv can be administered with or without food but should not be administered with high fat meals, due to increased exposure (see section 5.2).
Croatian: Intuniv se može primjenjivati s hranom ili bez nje, ali se zbog povećanja izloženosti ne smije se primjenjivati s obrocima s visokim udjelom masti (vidjeti dio 5.2).
English: Concomitant administration of guanfacine with OCT1 substrates with a similar Tmax (e.g., metformin) may result in increases in Cmax of these medicinal products.
Croatian: Istodobna primjena gvanfacina sa supstratima OCT1 sa sličnim Tmax (npr. metformin) može dovesti do povećanja Cmax tih lijekova.
English: Special populations There have been no studies performed in children with ADHD under the age of 6 years with Intuniv.
Croatian: Posebne populacije Nisu provedena ispitivanja s Intunivom u djece s ADHD-om mlađe od 6 godina.
English: The dose may be adjusted in increments of not more than 1 mg per week.
Croatian: Doza se može prilagoditi postupnim povećavanjem za najviše 1 mg tjedno.
English: Metabolism and nutrition disorders Decreased appetite
Croatian: Poremećaji metabolizma i prehrane smanjen apetit često
English: Patients should be advised that somnolence and sedation can occur, particularly early in treatment or with dose increases.
Croatian: Bolesnike treba upozoriti da se mogu javiti somnolencija i sedacija, osobito na početku liječenja ili kod povišenja doze.
English: • To stop the medicine, your doctor will slowly reduce your Intuniv dose to minimise any side effects.
Croatian: • Kod prestanka primjene lijeka, liječnik će Vam polako smanjivati dozu Intuniva kako bi se nuspojave svele na najmanju moguću mjeru.
English: Available pharmacodynamic and toxicological data in animals have shown excretion of guanfacine and its metabolites in milk (see section 5.3).
Croatian: Dostupni farmakodinamički i toksikološki podaci u životinja pokazuju da se gvanfacin i njegovi metaboliti izlučuju u mlijeko (vidjeti dio 5.3).
English: Checks your doctor will do when you take Intuniv
Croatian: Pretrage koje će provesti liječnik dok uzimate Intuniv
English: Bradycardia occurred in 1.5%, hypotension in 3.2% and syncope occurred in 0.7% of all guanfacine-treated patients.
Croatian: Bradikardija je nastala u 1,5%, hipotenzija u 3,2% i sinkopa u 0,7% svih bolesnika liječenih gvanfacinom.
English: • feeling restless or irritable
Croatian: • osjećaj nemira ili razdražljivosti
English: In this study, no effect on d-amphetamine exposure was observed following combination of Intuniv and lisdexamfetamine dimesylate.
Croatian: U ovom ispitivanju nije opažen nikakav učinak na izloženost d-amfetaminu nakon kombinirane primjene Intuniva i lisdeksamfetamindimesilata.
English: This medicine can help improve your attention, concentration and make you less impulsive and hyperactive.
Croatian: Vaše pozornosti, koncentracije i smanjiti Vašu impulzivnost i hiperaktivnost.
English: The physician who elects to use guanfacine for extended periods (over 12 months) should re-evaluate the usefulness of guanfacine every 3 months for the first year and then at least yearly based on clinical judgement (see section 4.4), and consider trial periods off medication to assess the patient's functioning without pharmacotherapy, preferably during times of school holidays.
Croatian: Liječnik koji odabere primjenjivati gvanfacin tijekom duljih razdoblja (više od 12 mjeseci) treba procjenjivati korist od gvanfacina svaka 3 mjeseca tijekom prve godine, a potom najmanje jedanput godišnje na temelju kliničke prosudbe (vidjeti dio 4.4) te razmotriti probna razdoblja bez lijeka kako bi procijenio funkcioniranje bolesnika bez farmakoterapije, po mogućnosti tijekom školskih praznika.
English: Intuniv is a prolonged-release tablet which means that the active substance is released from the tablet over a period of time.
Croatian: Intuniv je tableta s produljenim oslobađanjem što znači da se djelatna tvar oslobađa iz tablete tijekom određenog vremenskog razdoblja.
English: In addition 3 mg and 4 mg tablets include Indigo carmine aluminium lake E 132 Iron oxide yellow E 172
Croatian: Uz to tablete od 3 mg i 4 mg uključuju indigo carmine aluminium lake E 132 željezov oksid, žuti E 172
English: • medicines that lower your blood pressure (antihypertensives)
Croatian: • lijekove koji snižavaju krvni tlak (antihipertenzive)
English: Signs and symptoms of overdose may include hypotension, initial hypertension, bradycardia, lethargy, and respiratory depression.
Croatian: Znakovi i simptomi predoziranja mogu uključivati hipotenziju, početnu hipertenziju, bradikardiju, letargiju i respiratornu depresiju.
English: The major circulating metabolite is 3-OH-guanfacine sulphate which lacks pharmacological activity.
Croatian: Glavni cirkulirajući metabolit je 3-OH-gvanfacinsulfat, kojem nedostaje farmakološka aktivnost.
English: • Information on the risks associated with Intuniv: Bradycardia, Syncope, Hypotension/decreased blood pressure, withdrawal blood pressure increase, sedative events and weight increase
Croatian: • informacije o rizicima povezanima s Intunivom: bradikardija, sinkopa, hipotenzija/sniženi krvni tlak, povišenje krvnog tlaka prilikom ustezanja, sedacijske epizode i povećanje tjelesne težine
English: Reproductive system and breast disorders Erectile dysfunction
Croatian: Poremećaji reproduktivnog sustava i dojki erektilna disfunkcija
English: A significant increase in incidence of adenomas of the pancreatic islet was observed in male rats treated with 5 mg/kg/day guanfacine for 102 weeks but not in female rats.
Croatian: Značajno povećanje incidencije adenoma otočića gušterače bilo je opaženo u mužjaka štakora liječenih gvanfacinom u dozi od 5 mg/kg na dan tijekom 102 tjedna, ali ne i u ženki štakora.
English: The blister strips comprise of 2 layers, a clear thermoformable rigid film which is laminated with PCTFE to a PVC backing to which a push-through aluminium foil is adhered.
Croatian: Blisteri se sastoje od 2 sloja, prozirnog toplinski oblikovanog tvrdog filma koji je laminiran PCTFEom za podlogu od PVC-a uz koju priliježe protisna aluminijska folija.
English: • medicines that make you sleepy (sedatives)
Croatian: • lijekove od kojih ste pospani (sedativi)
English: Do not stop taking Intuniv without talking to your doctor.
Croatian: Nemojte prestati uzimati lijek Intuniv bez razgovora s liječnikom.
English: Preclinical research suggests guanfacine modulates signalling in the prefrontal cortex and basal ganglia through direct modification of synaptic noradrenalin transmission at the alpha 2- adrenergic receptors.
Croatian: Neklinička ispitivanja ukazuju na to da gvanfacin modulira signale u prefrontalnom korteksu i bazalnim ganglijima putem izravne modifikacije sinaptičkog prijenosa nodradrenalina preko alfa 2-adrenergičkih receptora.
English: If you suddenly stop taking Intuniv, you may develop withdrawal symptoms of increased heart rate and high blood pressure (see section 4).
Croatian: Ako iznenada prestanete uzimati Intuniv možete razviti simptome ustezanja poput ubrzanih otkucaja srca i povišenog krvnog tlaka (vidjeti dio 4).
English: • lack of energy (lethargy)
Croatian: • nedostatak energije (letargija)
English: You may feel dizzy and drowsy when taking this medicine, especially at the start of treatment and this may last for 2 to 3 weeks possibly longer.
Croatian: Možete osjetiti omaglicu i omamljenost kad uzimate ovaj lijek, osobito na početku liječenja, i to može trajati 2 do 3 tjedna, a moguće je i dulje.
English: • Chart for ongoing monitoring (vital signs, height, weight) of patients during treatment with Intuniv.
Croatian: • grafikon za trajno praćenje bolesnika (vitalni znakovi, visina, težina) tijekom liječenja Intunivom.
English: Intuniv is not recommended during pregnancy and in women of childbearing potential not using contraception.
Croatian: Ne preporučuje se koristiti lijek Intuniv tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju.
English: Based on in vitro studies, guanfacine is a substrate of OCT1 and OCT2, but not BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1 or MATE2.
Croatian: Na temelju ispitivanja in vitro, gvanfacin je supstrat OCT1 i OCT2, ali ne i BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1 ili MATE2.
English: Intuniv can increase plasma concentrations of concomitantly administered medicinal products that are metabolised via CYP3A4/5 (see sections 4.2, 4.4 and 5.2).
Croatian: Intuniv može povisiti koncentracije u plazmi istovremeno primijenjenih lijekova koji se metaboliziraju putem CYP3A4/5 (vidjeti dijelove 4.2, 4.4 i 5.2).
English: The following effects may happen: low or high blood pressure, slow heart rate, slow breathing rate, feeling tired or exhausted.
Croatian: Mogu nastati sljedeći učinci: nizak ili visok krvni tlak, usporeni puls, usporeno disanje, osjećaj umora ili iscrpljenosti.
English: • fits or convulsions
Croatian: • napadaji ili konvulzije
English: Intuniv contains lactose:
Croatian: Intuniv sadrži laktozu:
English: In human hepatic microsomes, guanfacine did not inhibit the activities of the other major cytochrome P450 isoenzymes (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 or CYP3A5); guanfacine is also not expected to be an inducer of CYP3A, CYP1A2 and CYP2B6.
Croatian: U mikrosomima ljudske jetre, gvanfacin nije inhibirao aktivnosti drugih glavnih izoenzima citokroma P450 (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 ili CYP3A5); isto tako, ne očekuje se da će gvanfacin biti induktor CYP3A, CYP1A2 i CYP2B6.
English: • Do not take grapefruit juice with this medicine as it can have an effect on the way this medicine works.
Croatian: • Nemojte piti sok od grejpfruta s ovim lijekom, jer to može utjecati na način na koji ovaj lijek djeluje.
English: Dose reduction may be required in patients with severe renal impairment (GFR 29-15 ml/min) and an end stage renal disease (GFR<15 ml/min) or requiring dialysis.
Croatian: U bolesnika s teškim oštećenjem funkcije bubrega (GFR 29-15 ml/min) i završnim stadijem bolesti bubrega (GFR<15 ml/min ili je potrebna dijaliza) može biti potrebno sniženje doze.
English: Hypotension, bradycardia and syncope
Croatian: Hipotenzija, bradikardija i sinkopa
English: Patients are advised against operating heavy equipment, driving or cycling until they know how they respond to treatment with Intuniv (see section 4.7).
Croatian: Bolesnicima se savjetuje da ne upravljaju strojevima, vozilima ili biciklima sve dok ne saznaju kako odgovaraju na liječenje Intunivom (vidjeti dio 4.7).
English: Guanfacine is not an inhibitor of BSEP, MRP2, OATP1B1, OATP1B3, OAT1, OAT3, OCT2 or MATE2K, but it is an inhibitor of MATE1 and may be an inhibitor of OCT1 at maximal portal vein concentrations.
Croatian: Gvanfacin nije inhibitor BSEP, MRP2, OATP1B1, OATP1B3, OAT1, OAT3, OCT2 ili MATE2K, ali je inhibitor MATE1 i može biti inhibitor OCT1 pri maksimalnim koncentracijama u portalnoj veni.
English: 6 monthly monitoring should follow thereafter, with more frequent monitoring following any dose adjustment.
Croatian: Nakon toga treba uslijediti praćenje svakih 6 mjeseci, uz češće praćenje nakon svake prilagodbe doze.
English: Intuniv should not be administered together with grapefruit juice (see section 4.5).
Croatian: Intuniv se ne smije primjenjivati sa sokom od grejpfruta (vidjeti dio 4.5).
English: Treatment must be initiated under the supervision of an appropriate specialist in childhood and/or adolescent behavioural disorders.
Croatian: Liječenje se mora započeti pod nadzorom odgovarajućeg specijalista za poremećaje ponašanja u djece i/ili adolescenata.
English: • Checklist for discontinuation of guanfacine including monitoring blood pressure and pulse of patients during downward titration.
Croatian: • Kontrolna lista za prekid liječenja gvanfacinom uključujući praćenje krvnog tlaka i pulsa bolesnika tijekom postupnog snižavanja doze.