FrancophonIA/ELRC3.0 huggingface dataset:
English: Official, national and regional antimicrobial policies should be taken into account when the product is used.
Slovenian: Pri uporabi zdravila je treba upoštevati uradne, nacionalne in regionalne antimikrobne politike.
English: The overall benefit-risk balance of the product for use in cattle and sheep was deemed positive subject to the recommended changes in the product information (see annex III).
Slovenian: Celotno razmerje med tveganji in koristmi za zdravilo za uporabo pri govedu in ovcah je bilo ocenjeno kot ugodno pod pogojem, da se upoštevajo priporočene spremembe v informacijah o zdravilu (glejte Prilogo III).
English: A slight increase in MIC levels could be observed for Mannheimia haemolytica isolates over the last decade, most of isolates (83%) were clinically susceptible to tilmicosin.
Slovenian: Rahlo povečanje ravni MIK je bilo mogoče opaziti za izolate bakterije Mannheimia haemolytica v zadnjem desetletju, od katerih je bila večina izolatov (83 %) klinično dovzetna na tilmikozin.
English: Milk: 36 days
Slovenian: Mleko: 36 dni
English: Administration of dobutamine should also be considered due to its positive inotropic effects although it does not influence tachycardia.
Slovenian: O uporabi dobutamina je treba razmisliti zaradi njegovih pozitivnih inotropnih učinkov, čeprav ne vpliva na tahikardijo.
English: TARGET SPECIES Cattle and sheep INDICATION(S)
Slovenian: CILJNE ŽIVALSKE VRSTE Govedo in ovce INDIKACIJA(E)
English: Do not use this veterinary medicinal product after the expiry date which is stated on the label after EXP. Shelf-life after first opening the container: 28 days
Slovenian: Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na nalepki po EXP. Rok uporabnosti po odprtju vsebnika: 28 dni
English: This led the CVMP in 2005 to limit the use of Micotil to sheep weighing more than 15 kg and to be administered by veterinary surgeons only (referral procedure under Article 35 of Directive 2001/82/EC, for Micotil 300 (EMEA/V/A/010)).
Slovenian: Zaradi tega je CVMP leta 2005 omejil uporabo zdravila Micotil na ovce, težje od 15 kg, zdravilo pa lahko dajejo samo veterinarji (napotitveni postopek v skladu s členom 35 Direktive 2001/82/ES za zdravilo Micotil 300 (EMEA/V/A/010)).
English: An overdosage is likely to happen for such a small amount of product.
Slovenian: Pri tako majhnih količinah zdravila je zelo verjetno preveliko odmerjanje.
English: Overall summary of the scientific evaluation of Micotil 300 mg/ml Injectie and its associated names (see annex I)
Slovenian: Splošni povzetek znanstvenega vrednotenja zdravila Micotil 300 mg/ml Injectie in z njim povezanih imen (glejte Prilogo I)
English: Higher doses (150 mg/kg body weight) caused ataxia, lethargy and the inability to raise the head.
Slovenian: Večji odmerki (150 mg/kg telesne mase) so povzročili ataksijo, letargijo in nezmožnost dvigovanja glave.
English: As expected, oedema developed at the site of injection.
Slovenian: Kot je bilo pričakovano, se je na mestu injiciranja pojavil edem.
English: Therefore it is difficult to assess the efficacy of tilmicosin since no bacteriological diagnosis was conducted and both tilmicosin as well as the positive control were administered as a preventive therapeutic, five days before parturition.
Slovenian: Zato je težavno oceniti učinkovitost tilmikozina, saj ni bilo izvedenih nobenih bakterioloških diagnoz, tilmikozin in pozitivne kontrole pa so bili dani preventivno terapevtsko, pet dni pred kotitvijo.
English: The clinical studies used naturally infected cattle with interdigital necrobacillosis without a bacteriological diagnosis.
Slovenian: V klinične študije so vključili naravno okuženo govedo z interdigitalno nekrobacilozo brez bakteriološke diagnostike.
English: The second clinical trial which studied efficacy of tilmicosin against reproductive diseases showed no inferiority towards the positive control (penicillin combined with an aminoglycoside) however no negative controls were included.
Slovenian: V drugem kliničnem preskušanju, v katerem so preučevali učinkovitost tilmikozina pri boleznih reprodukcije, niso zabeležili nobene inferiornosti v primerjavi s pozitivno kontrolo (penicilin, skupaj z aminoglikozidom), vendar ni bilo vključenih nobenih negativnih kontrol.
English: Treatment of interdigital necrobacillosis.
Slovenian: Zdravljenje interdigitalne nekrobaciloze.
English: For the full list of excipients, see section 6.1.
Slovenian: tilmikozin 300 mg Za celoten seznam pomožnih snovi glejte poglavje 6.1.
English: In milk, a concentration of tilmicosin of 1.2 µg/ml at day 3 has been measured indicating a concentration above most MIC values of the pathogens.
Slovenian: Pri mleku so izmerili koncentracijo tilmikozina 1,2 µg/ml na 3. dan, kar označuje koncentracije nad večino vrednosti MIK za patogene.
English: Apply a cold pack (not ice directly) to the injection site.
Slovenian: Na mesto injiciranja namestite hladno oblogo (ne polagajte ledu neposredno nanj).
English: The results show that, when administered as recommended to calves and sheep by subcutaneous injection over the dorso-lateral chest, the main parameters are:
Slovenian: Rezultati kažejo, da so ob priporočeni uporabi pri teletih in ovcah s subkutanim injiciranjem v dorzolateralni predel prsnega koša glavni parametri naslednji:
English: Administration of intravenous calcium chloride should only be considered if there is positive confirmation of exposure to tilmicosin.
Slovenian: O uporabi intravenskega kalcijevega klorida je treba razmisliti samo, če je bila izpostavitev tilmikozinu potrjena.
English: To avoid self-injection do not use automatic injection equipment.
Slovenian: Da se izognete samoinjiciranju, ne uporabljajte opreme za samodejno injiciranje.
English: Bordetella bronchiseptica was not isolated in any clinical or preclinical study and no in vitro study has been performed with this bacteria.
Slovenian: Bakterija Bordetella bronchiseptica ni bila izolirana v nobeni klinični ali predklinični študiji in s to bakterijo ni bila izvedena nobena študija in vitro.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGE Glass vial - base label (fold out label details are the same as the package leaflet)
Slovenian: Steklena viala - osnovna nalepka (podrobnosti na so enake kot v navodilu za uporabo)
English: The Netherlands referred the issue due to divergent national decisions having been taken by the EU Member States resulting in discrepancies in the product information for Micotil 300 mg/ml Injectie and its associated names.
Slovenian: Nizozemska je sprožila napotitev zaradi različnih nacionalnih odločitev, ki so jih sprejele države članice EU, kar je povzročilo odstopanja v informacijah o zdravilu za zdravilo Micotil 300 mg/ml Injectie in z njim povezana imena.
English: Dobutamine partially offset the negative inotropic effects induced by tilmicosin in dogs.
Slovenian: Dobutamin je delno kompenziral negativne inotropne učinke, ki jih je tilmikozin povzročil pri psih.
English: List of the names, pharmaceutical forms, strengths of the veterinary medicinal product, animal species, route of administration, marketing authorisation holders in the Member States
Slovenian: Seznam imen, farmacevtskih oblik, jakosti zdravila za uporabo v veterinarski medicini, živalskih vrst, poti uporabe in imetnikov dovoljenja za promet z zdravilom v državah članicah
English: • In case of self-injection SEEK IMMEDIATE MEDICAL ATTENTION and take the vial or the package leaflet with you.
Slovenian: • V primeru samoinjiciranja SE TAKOJ POSVETUJTE Z ZDRAVNIKOM in mu pokažite navodila za uporabo ali vialo.
English: Micotil 300 Injectie and its associated names are veterinary medicinal products authorised for use in the target species cattle, sheep and rabbits for treatment of various infections caused by microorganisms susceptible to tilmicosin.
Slovenian: Zdravilo Micotil 300 Injectie in z njim povezana imena so zdravila za uporabo v veterinarski medicini, ki so odobrena za uporabo pri ciljnih vrstah goveda, ovc in kuncev za zdravljenje različnih okužb, ki jih povzročajo mikroorganizmi, dovzetni na tilmikozin.
English: Do not administer to horses and donkeys.
Slovenian: Ne uporabljajte pri konjih in oslih.
English: Mannheimia, Pasteurella, Actinomyces (Corynebacterium), Fusobacterium, Dichelobacter, Staphylococcus, and Mycoplasma organisms of bovine and ovine origin.
Slovenian: Mannheimia, Pasteurella, Actinomyces (Corynebacterium), Fusobacterium, Dichelobacter, Staphylococcus ter organizmom Mycoplasma govejega in ovčjega izvora.
English: Staphylococcus aureus was not isolated in any preclinical study or clinical trial.
Slovenian: Bakterija Staphylococcus aureus ni bila izolirana v nobeni predklinični študiji ali v kliničnem preskušanju.
English: The use of the product should be based on susceptibility tests.
Slovenian: Uporaba tega zdravila mora temeljiti na preiskavah susceptibilnosti.
English: • This product should only be administered by a veterinary surgeon.
Slovenian: • To zdravilo lahko daje samo veterinarski kirurg.
English: • Do not use automatic injection equipment.
Slovenian: • Ne uporabljajte opreme za samodejno injiciranje.
English: Numerous field studies using naturally infected calves of various ages with pneumonia, conducted over 20 years ago, indicated that tilmicosin is not inferior towards other positive controls, being long acting antibiotics or combinations of two antibiotics.
Slovenian: Številne študije na terenu, v katere je bilo vključeno naravno okuženo govedo različnih starosti s pljučnico in so bile izvedene pred več kot 20 leti, nakazujejo, da tilmikozin ni slabši do drugih pozitivnih kontrol, na primer dolgodelujočih antibiotikov ali kombinacij dveh antibiotikov.
English: Biotransformation: Several metabolites are formed, the predominant one being identified as T1 (Ndemethyl tilmicosin).
Slovenian: Biotransformacija: Tvorili so se mnogi presnovki, od katerih je bil glavni T1 (N-demetiltilmikozin).
English: MIC measured in these isolates did not show an increase in MIC levels for Pasteurella multocida (97% of the isolates were susceptible to tilmicosin), therefore from the data provided no trend in resistance increase could be observed for one of the major pathogens for respiratory diseases in cattle.
Slovenian: Vrednosti MIK, izmerjene v teh izolatih, niso pokazale povišanja ravni MIK za bakterijo Pasteurella multocida (97 % izolatov je bilo dovzetnih na tilmikozin), zato iz predloženih podatkov ni mogoče opaziti nobenega trenda povečanja odpornosti za enega najpomembnejših patogenov za bolezni dihal pri govedu.
English: Additional operator safety warnings:
Slovenian: Dodatna varnostna opozorila za uporabnika:
English: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with national requirements.
Slovenian: Vsako neporabljeno zdravilo za uporabo v veterinarski medicini ali odpadne snovi, ki nastanejo iz teh zdravil, je treba odstraniti skladno z lokalnimi predpisi.
English: Macrolides appear to enhance phagocyte killing of bacteria.
Slovenian: Videti je, da makrolidi okrepijo pobijanje bakterij, ki ga povzročajo fagociti.
English: The MIC90 data from recently isolated European strains should be included in SPC section 5.1 Pharmacodynamic properties.
Slovenian: Podatke MIK90 iz nedavno izoliranih evropskih sevov je treba vključiti v poglavje 5.1 Farmakodinamične lastnosti povzetka glavnih značilnosti zdravila.
English: Tilmicosin is a mainly bactericidal semi-synthetic antibiotic of the macrolide group.
Slovenian: Tilmikozin je večinoma baktericidni polsintetični antibiotik iz skupine makrolidov.
English: Cattle and sheep
Slovenian: Govedo in ovce
English: Benefit-Risk assessment
Slovenian: Ocena razmerja med tveganji in koristmi
English: Cardiovascular toxicity may be due to calcium channel blockade.
Slovenian: Kardiovaskularna toksičnost je lahko posledica blokade kalcijevih kanalčkov.
English: Avoid introduction of contamination into vial during use.
Slovenian: Med uporabo preprečite kontaminacijo v viali.
English: The CVMP concluded that, due to limited availability of alternative veterinary medicinal products for this indication and in the absence of reports on suspected lack of efficacy, the indication “for treatment of ovine mastitis associated with Staphylococcus aureus and Mycoplasma agalactiae” should be maintained, but in a modified manner to better reflect the study results, to “treatment of acute ovine mastitis associated with Staphylococcus aureus and Mycoplasma agalactiae”.
Slovenian: CVMP je zaključil, da je treba zaradi omejene razpoložljivosti alternativnih zdravil za uporabo v veterinarski medicini za to indikacijo in zaradi odsotnosti poročil o domnevnem pomanjkanju učinkovitosti indikacijo „za zdravljenje mastitisa pri ovcah, povezanega z bakterijama Staphylococcus aureus in Mycoplasma agalactiae“ ohraniti, vendar spremeniti tako, da bolje odraža rezultate študije, in sicer „za zdravljenje akutnega mastitisa pri ovcah, povezanega z bakterijama Staphylococcus aureus in Mycoplasma agalactiae“.
English: The safety of the veterinary medicinal product has not been established during pregnancy.
Slovenian: Varnost zdravila v obdobju brejosti ni bila ugotovljena.
English: Veterinary medicinal product must not be disposed of via waste water or the drainage systems.
Slovenian: Zdravila za uporabo v veterinarski medicini ne smete zavreči v odpadne vode ali drenažne sisteme.
English: • May cause sensitisation by skin contact.
Slovenian: • Ob stiku s kožo lahko povzroči senzibilizacijo.
English: In pigs, intramuscular injection of 10 mg tilmicosin/kg body weight caused increased respiration, emesis and convulsions; 20 mg/kg body weight resulted in mortality in 3 of 4 pigs, and 30 mg/kg body weight caused the death of all 4 pigs tested.
Slovenian: Pri prašičih je intramuskularno injiciranje 10 mg tilmikozina/kg telesne mase povzročilo pospešeno dihanje, emezo in konvulzije; odmerek 20 mg/kg telesne mase je povzročil smrt 3 od 4 prašičev, odmerek 30 mg/kg telesne mase pa smrt vseh 4 testiranih prašičev.
English: THE WORDS “FOR ANIMAL TREATMENT ONLY” AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, IF APPLICABLE For animal treatment only.
Slovenian: BESEDILO »SAMO ZA ŽIVALI« IN POGOJI ALI OMEJITVE GLEDE OSKRBE IN
English: In sheep single injections (approximately 30 mg/kg body weight) may cause a slight increase of the rate of respiration.
Slovenian: Pri ovcah lahko enkratno injiciranje (v odmerku približno 30 mg/kg telesne mase) povzroči rahlo povečanje frekvence dihanja.
English: Elimination: Following subcutaneous injection, tilmicosin is excreted mainly via the bile into the faeces, but a small proportion is excreted via the urine.
Slovenian: Izločanje: Po subkutanem injiciranju se tilmikozin izloča zlasti prek žolča z blatom, majhen delež pa se izloči z urinom.
English: Animal species Route of administration
Slovenian: Živalska vrsta Pot uporabe
English: The Netherlands
Slovenian: Nizozemska NIZOZEMSKA
English: Intravenous injection in cattle and sheep has been fatal.
Slovenian: Intravensko injiciranje pri govedu in ovcah je povzročilo smrt.
English: Since no dose-finding studies in rabbits were provided it cannot be concluded from the data available that Pasteurellosis can be treated with the recommended tilmicosin dosage of 10 mg/kg body weight.
Slovenian: Ker ni bilo predloženih nobenih študij za določitev odmerka pri kuncih, iz razpoložljivih podatkov ni mogoče zaključiti, da je mogoče bakterijo Pasteurellosis zdraviti s priporočenim odmerkom tilmikozina 10 mg/kg telesne mase.
English: When a group of animals has to be treated, leave the needle in the vial to remove the subsequent doses.
Slovenian: Če zdravite skupino živali, pustite iglo v viali, da lahko izvlečete naslednje odmerke.
English: Pre-clinical data and an isolated clinical report suggest that calcium chloride infusion may help to reverse tilmicosin induced changes in blood pressure and heart rate in humans.
Slovenian: Predklinični podatki in eno klinično poročilo kažejo, da lahko infundiranje kalcijevega klorida pomaga odpraviti spremembe krvnega tlaka in srčnega utripa, ki jih pri človeku povzroči tilmikozin.
English: Beta adrenergic antagonists such as propanolol exacerbated the negative inotrophy of tilmicosin in dogs.
Slovenian: Antagonisti beta-adrenergičnih receptorjev, kot je propanolol, so poslabšali negativno inotropijo zaradi tilmikozina pri psih.
English: 10 mg/kg body weight 10 mg/kg body weight
Slovenian: 10 mg/kg telesne mase 10 mg/kg telesne mase
English: Do not use “product name (to be completed nationally)” if you notice any foreign particulate matter and/or abnormal physical appearance.
Slovenian: Zdravila »ime zdravila (izpolni država članica)« ne uporabljajte, če opazite tujke in/ali če je prišlo do spremembe v fizikalnem videzu vsebine.
English: Withdraw the required dose from the vial and remove the syringe from the needle, leaving the needle in the vial.
Slovenian: Iz viale izvlecite potreben odmerek in odstranite injekcijsko brizgo z igle, iglo pa pustite v viali.
English: The only lesion observed at autopsy was a necrosis of the myocardium in the group treated with 50 mg/kg body weight.
Slovenian: Edina lezija, ki se je opazila pri obdukciji, je bila nekroza miokardija v skupini, zdravljeni z odmerkom 50 mg/kg telesne mase.
English: Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Slovenian: Posebni previdnostni ukrepi, ki jih mora izvajati oseba, ki živalim daje zdravilo Varnostna opozorila za uporabnika:
English: Distribution: Following subcutaneous injection, tilmicosin is distributed throughout the body, but especially high levels are found in the lung.
Slovenian: Porazdelitev: Po subkutanem injiciranju se tilmikozin porazdeli po telesu, predvsem visoke ravni pa so ugotovili v pljučih.
English: In cattle subcutaneous injections of 10, 30 and 50 mg/kg body weight, repeated three times with a 72 hours interval, did not cause death.
Slovenian: Pri govedu subkutano injiciranje odmerkov 10, 30 in 50 mg/kg telesne mase, danih trikrat v 72-urnih presledkih, ni povzročilo smrti.
English: Use 10 mg tilmicosin per kg body weight (corresponding to 1 ml “product name (to be completed nationally)” per 30 kg body weight).
Slovenian: Uporabite 10 mg tilmikozina na kg telesne mase (kar je enako 1 ml zdravila »ime zdravila (izpolni država članica)« na 30 kg telesne mase).
English: No inferiority was seen between the tilmicosin groups and positive controls, being long acting antibiotics.
Slovenian: Med skupinami, ki so prejemale tilmikozin, in pozitivnimi kontrolami, ki so prejemale dolgodelujoče antibiotike, niso opazili nobene inferiornosti.
English: The Clinical and Laboratory Standards Institute (CLSI) has set the interpretive criteria for tilmicosin against M. haemolyica of bovine origin and specifically for bovine respiratory disease, as ≤8µg/ml = susceptible, 16 µg/ml = intermediate and ≥ 32 µg/ml = resistant.
Slovenian: Inštitut za klinične in laboratorijske standarde (Clinical and Laboratory Standards Institute - CLSI) je določil interpretativna merila za tilmikozin proti bakteriji M. haemolyica govejega izvora, še zlasti za respiratorno bolezen govedi, in sicer ≤ 8 µg/ml = susceptibilno, 16 µg/ml = srednje in ≥ 32 µg/ml =
English: Manufacturer responsible for batch release: To be completed nationally
Slovenian: Izdelovalec, odgovoren za sproščanje serij: Izpolni država članica.
English: The absence of bacteriological cure demonstration in the clinical study should be stated in the SPC in section 4.4 Special warnings for each target species.
Slovenian: Odsotnost prikaza bakteriološke ozdravitve v klinični študiji je treba navesti v poglavju 4.4 Posebna opozorila v povzetku glavnih značilnosti zdravila za vsako ciljno vrsto.
English: A dose of 30 mg/kg body weight resulted in increased respiratory rate.
Slovenian: Odmerek 30 mg/kg telesne mase je povzročil povečano hitrost dihanja.
English: The indication “as an aid in the control of outbreaks of enzootic abortion in ewes caused by Chlamydia psittaci” was only supported by positive control data.
Slovenian: Indikacija „kot pomoč pri obvladovanju izbruhov enzootskega zvrgavanja ovac, ki ga povzroča bakterija Chlamydia psittaci”, je bila podprta samo s podatki pozitivnih kontrol.
English: The needle should be connected to the syringe only when filling the syringe or administering the injection.
Slovenian: Iglo pritrdite na injekcijsko brizgo samo, ko polnite injekcijsko brizgo ali injicirate zdravilo.
English: Do not administer to lambs weighing less than 15 kg.
Slovenian: Ne uporabljajte pri jagnjetih s telesno maso, manjšo od 15 kg.
English: Regarding the treatment of acute ovine mastitis associated with Staphylococcus aureus and Mycoplasma agalactiae, the pathogens Staphylococcus aureus and Mycoplasma agalactiae appear to be sensitive for tilmicosin according to the measured MIC values (S. aureus MIC <0.25-1 µg/ml, M. agalactiae MIC=0.5 µg/ml).
Slovenian: V zvezi z zdravljenjem akutnega mastitisa pri ovcah, povezanega s Staphylococcus aureus in Mycoplasma agalactiae, se zdi, da sta patogena Staphylococcus aureus in Mycoplasma agalactiae občutljiva na tilmikozin v skladu z izmerjenimi vrednostmi MIK (S. aureus MIC < 0,25−1 µg/ml, M. agalactiae MIK = 0,5 µg/ml).
English: Tolerance studies clearly demonstrate that a dosage of 20 mg/kg body weight subcutaneous tilmicosin injection in lambs (7-11 kg) was toxic, leading to deaths.
Slovenian: Študije tolerance so jasno pokazale, da je bilo subkutano injiciranje tilmikozina pri odmerku 20 mg/kg telesne mase pri ovcah (7−11 kg) toksično, kar je povzročilo smrt.
English: Absorption: Several studies have been conducted.
Slovenian: 5.2 Farmakokinetični podatki Absorpcija: Opravili so več študij.
English: In dog studies, tilmicosin induced a negative inotropic effect with consequent tachycardia, and a reduction in systemic arterial blood pressure and arterial pulse pressure.
Slovenian: V študijah na psih je tilmikozin induciral negativni inotropni učinek s posledično tahikardijo ter znižanje sistemskega arterijskega krvnega tlaka in arterijskega pulznega tlaka.
English: Do not inject more than 20 ml per injection site.
Slovenian: V eno mesto injiciranja ne injicirajte več kot 20 ml.
English: Pharmacokinetic studies demonstrate that concentrations of tilmicosin in the lung can exceed 2 µg/ml for more than 3 days which would be therapeutic for M. haemolytica, Trueperella pyogenes (formerly known as Actinomyces pyogenes), Staphylococcus aureus and Mycoplasma ovipneumonia according to in vitro studies conducted in 1992.
Slovenian: Farmakokinetične študije kažejo, da lahko koncentracije tilmikozina v pljučih presežejo 2 µg/ml za več kot 3 dni, kar je v skladu z in vitro študijami iz leta 1992 terapevtsko za bakterije M. haemolytica, Trueperella pyogenes (prej znano kot Actinomyces pyogenes), Staphylococcus aureus in Mycoplasma ovipneumonia.
English: Meat and offal: 42 days Milk: 18 days
Slovenian: Meso in drobovina: 42 dni Mleko: 18 dni
English: Since the MIC values of M. haemolytica tended to increase over the last decade the MIC90 data from recently isolated European strains should be included in SPC section 5.1 Pharmacodynamic properties.
Slovenian: Ker so se vrednosti MIK za bakterijo M. haemolytica v zadnjem desetletju običajno višale, je treba v poglavje 5.1 Farmakodinamične lastnosti v povzetku glavnih značilnosti zdravila vključiti podatek MIK90 iz nedavno izoliranih evropskih sevov.
English: The recommended dose rate of 5 to 10 mg/kg body weight seems justified based on the available data, however pharmacokinetic studies combined with in vitro MIC studies imply that a dose of 10 mg/kg body weight would be preferable for curing the major pathogens in interdigital necrobacillosis in cattle.
Slovenian: Priporočeni odmerek od 5 do 10 mg/kg telesne mase se zdi upravičen na osnovi razpoložljivih podatkov, vendar farmakokinetične študije skupaj z in vitro študijami MIK nakazujejo, da bi bilo za zdravljenje pomembnejših patogenov pri interdigitalni nekrobacilozi pri govedu bolje uporabiti odmerek 10 mg/kg telesne mase.