FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients receiving Atripla or any other antiretroviral therapy may continue to develop opportunistic infections and other complications of HIV infection, and therefore should remain under close clinical observation by physicians experienced in the treatment of patients with HIV associated diseases.
Croatian: U bolesnika koji primaju Atriplu ili neku drugu antiretrovirusnu terapiju mogu se i dalje razvijati oportunističke infekcije i druge komplikacije infekcije HIV-om, pa bi zbog toga trebali ostati pod strogim kliničkim nadzorom liječnika koji imaju iskustva u liječenju bolesnika s bolestima povezanim s HIV-om.
English: If there is evidence of worsening liver disease or persistent elevations of serum transaminases to greater than 5 times the upper limit of the normal range, the benefit of continued therapy with Atripla needs to be weighed against the potential risks of significant liver toxicity.
Croatian: Postoje li dokazi o pogoršanju bolesti jetre ili stalno povišenje serumskih transaminaza za više od 5 puta iznad gornje granice normalnog raspona, nužno je procijeniti koristi nastavka terapije Atriplom naprema mogućim rizicima značajne toksičnosti za jetru.
English: In vitro binding of emtricitabine to human plasma proteins is < 4% and independent of concentrations over the range of 0.02 to 200 µg/ml.
Croatian: In vitro vezivanje emtricitabina na proteine ljudske plazme je < 4% i neovisno je o koncentracijama u rasponu od 0,02 do 200 µg/ml.
English: - Bupropion, a medicine used to treat depression or to help you stop smoking, as your doctor may need to change your dose of bupropion.
Croatian: - Bupropion, lijek koji se koristi za liječenje depresije ili kao pomoć za prestanak pušenja: liječnik će Vam možda morati promijeniti dozu bupropiona.
English: All 3 subjects had received a fixed dose combination of lamivudine and zidovudine (Combivir) and efavirenz for 144 weeks and then switched to Atripla.
Croatian: Sva 3 ispitanika primala su fiksnu dozu kombinacije lamivudina i zidovudina (Combivir) i efavirenz 144 tjedana, a potom su bili prebačeni na Atriplu.
English: Studies conducted with other medicinal products
Croatian: Ispitivanja provedena s drugim lijekovima
English: Following oral administration, the elimination half-life of emtricitabine is approximately 10 hours.
Croatian: Nakon peroralne primjene, poluvrijeme eliminacije emtricitabina je približno 10 sati.
English: • itchy rash to the skin caused by a reaction to sunlight
Croatian: • osip na koži koji svrbi uzrokovan reakcijom na sunce
English: The safety and efficacy of Atripla have not been studied for the treatment of chronic HBV infection.
Croatian: Nije provedeno ispitivanje sigurnosti i djelotvornosti primjene Atriple u liječenju kronične infekcije virusom HBV-a.
English: Confirmatory testing by a more specific method such as gas chromatography/mass spectrometry is recommended in such cases.
Croatian: U takvim se slučajevima preporučuje potvrditi pozitivan rezultat specifičnijom metodom kao što je plinska kromatografija/masena spektrometrija.
English: Modified LOCF: Post-hoc analysis where patients who failed virologically or discontinued for adverse events were treated as failures; for other drop-outs, the LOCF (last observation carried forward) method was applied
Croatian: Prilagođeni LOCF: Post-hoc analiza u kojoj su bolesnici u kojih je došlo do virološkog neuspjeha ili su prestali s liječenjem zbog nuspojava tretirani kao neuspješni; na ostale isključene bolesnike primijenjena je metoda LOCF (engl. last observation carried forward)
English: Sufficient data on the tolerability of efavirenz with low-dose ritonavir (100 mg, once or twice daily) are not available.
Croatian: Nije dostupno dovoljno podataka o toleranciji efavirenza u kombinaciji s niskom dozom ritonavira (100 mg, jednom ili dva puta dnevno).
English: Patients with mild liver disease (Child-Pugh-Turcotte (CPT), Class A) may be treated with the normal recommended dose of Atripla (see sections 4.3, 4.4 and 5.2).
Croatian: Bolesnici s blagom bolešću jetre (Child-Pugh-Turcotte (CPT), stadij A) mogu se liječiti uobičajenom preporučenom dozom Atriple (vidjeti dio 4.3, 4.4 i 5.2).
English: Despite the decrease in buprenorphine exposure, no patients exhibited withdrawal symptoms.
Croatian: Unatoč smanjenju izloženosti buprenorfinu, nijedan bolesnik nije pokazao simptome apstinencijske krize.
English: Patients should be advised that if they experience symptoms such as severe depression, psychosis or suicidal ideation, they should contact their doctor immediately to assess the possibility that the symptoms may be related to the use of efavirenz, and if so, to determine whether the risk of continued therapy outweighs the benefits (see section 4.8).
Croatian: Bolesnike treba uputiti da se, osjete li simptome poput teške depresije, psihoze ili samoubilačkih ideja, moraju odmah obratiti svojem liječniku radi procjene moguće povezanosti tih simptoma s upotrebom efavirenza te, ako je tako, radi utvrđivanja nadmašuje li rizik uslijed nastavka terapije koristi od terapije (vidjeti dio 4.8).
English: Efavirenz concentrations not measured, no effect is expected.
Croatian: Koncentracije efavirenza nisu mjerene, ne očekuje se nikakav učinak.
English: Carcinogenicity studies in male mice, male and female rats were negative.
Croatian: Istraživanja kancerogenosti u muških miševa te muških i ženskih štakora bila su negativna.
English: Experience with efavirenz in patients who discontinued other antiretroviral agents of the NNRTI class is limited.
Croatian: Iskustva s efavirenzom u bolesnika koji su prekinuli uzimanje drugih antiretrovirusnih lijekova klase NNRTI ograničena su.
English: Talk to your doctor or pharmacist before taking Atripla.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete Atriplu.
English: If overdose occurs, the patient must be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Croatian: U slučaju predoziranja bolesnik mora biti pod nadzorom zbog znakova toksičnosti (vidjeti dio 4.8) te mu se, prema potrebi, mora pružiti standardno potporno liječenje.
English: These side effects may start in the first 1 or 2 days of treatment and usually go away after the first 2 to 4 weeks.
Croatian: Te nuspojave mogu se pojaviti u prvih 1 ili 2 dana liječenja, a obično nestaju nakon prva 2 do 4 tjedna.
English: In clinical controlled studies of efavirenz, nervous system symptoms of moderate to severe intensity were experienced by 19% (severe 2%) of patients, and 2% of patients discontinued therapy due to such symptoms.
Croatian: U klinički kontroliranim ispitivanjima efavirenza simptomi živčanog sustava umjerenog do teškog intenziteta uočeni su u 19% (teški oblik 2%) bolesnika, a u 2% bolesnika terapija je zbog tih simptoma prekinuta.
English: Patients should be informed that if they do occur, these common symptoms are likely to improve with continued therapy and are not predictive of subsequent onset of any of the less frequent psychiatric symptoms.
Croatian: Bolesnicima treba objasniti da će se, ukoliko se pojave, ti česti simptomi vjerojatno ublažiti tijekom trajanja terapije te da se na temelju njih ne može predvidjeti naknadna pojava bilo kakvih manje čestih psihijatrijskih simptoma.
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to CART.
Croatian: Iako se smatra da je etiologija multifaktorska (uključujući primjenu kortikosteroida, konzumaciju alkohola, tešku imunosupresiju, veći indeks tjelesne mase), zabilježeni su slučajevi osteonekroze osobito u bolesnika s uznapredovalom HIV-bolešću i/ili dugotrajnom izloženošću CART-u.
English: Immune system disorders: Common allergic reaction
Croatian: Poremećaji imunološkog sustava: Često alergijske reakcije
English: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Croatian: U nekih se bolesnika koji uzimaju kombiniranu antiretrovirusnu terapiju može razviti koštana bolest koja se naziva osteonekrozom (odumiranje koštanog tkiva uzrokovano prestankom opskrbe kosti krvlju).
English: Also, emtricitabine did not inhibit uridine 5'-diphosphoglucuronyl transferase, the enzyme responsible for glucuronidation.
Croatian: Isto tako, ni emtricitabin nije inhibirao uridin-5'-difosfoglukoriniltransferazu, enzim odgovoran za glukuronidaciju.
English: These are listed under Do not take Atripla, at the start of section 2.
Croatian: Ti su lijekovi navedeni pod Nemojte uzimati Atriplu na početku dijela 2.
English: Women should not get pregnant during treatment with Atripla and for 12 weeks thereafter.
Croatian: Žene ne bi smjele zatrudnjeti tijekom liječenja Atriplom niti 12 tjedana nakon prekida liječenja.
English: This may make some side effects (for example, dizziness, drowsiness) less troublesome.
Croatian: To može smanjiti negativan utjecaj nekih nuspojava (na primjer, omaglice, omamljenosti).
English: Voxilaprevir:↓
Croatian: Očekivano: voxilaprevir:↓
English: These patients should be carefully monitored for efavirenz adverse reactions, especially nervous system symptoms.
Croatian: Te bolesnike potrebno je pomno pratiti radi pojave nuspojava efavirenza, naročito simptoma na živčanom sustavu.
English: Tenofovir concentrations not measured, no effect is expected.
Croatian: Koncentracije tenofovira nisu mjerene, ne očekuje se nikakav učinak.
English: Co-administration of atazanavir/ritonavir with tenofovir resulted in increased exposure to tenofovir.
Croatian: Istodobna primjena atazanavira/ritonavira s tenofovirom dovela je do povećane izloženosti tenofoviru.
English: Compounds or herbal preparations (for example Ginkgo biloba extracts and St. John's wort) which induce these enzymes may give rise to decreased plasma concentrations of efavirenz.
Croatian: Spojevi ili biljni pripravci (na primjer, ekstrakt Ginkgo bilobe i gospina trava), koji induciraju ove enzime, mogu dovesti do smanjenja koncentracije efavirenza u plazmi.
English: Efavirenz plasma exposure may be increased in patients with homozygous G516T genetic variant of the CYP2B6 isozyme.
Croatian: Plazmatska izloženost efavirenzu može biti povećana kod bolesnika s homozigotskom genskom inačicom G516T izozima CYP2B6.
English: Metabolism and nutrition disorders: Very common hypophosphataemia2
Croatian: Poremećaji metabolizma i prehrane: Vrlo često hipofosfatemija2
English: You do not need to take another tablet if you were sick more than 1 hour after taking Atripla.
Croatian: Drugu tabletu ne trebate uzimati ako ste povraćali nakon što je prošlo više od 1 sat nakon uzimanja Atriple.
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Croatian: Terapiju mora započeti liječnik s iskustvom u liječenju infekcije HIV-om.
English: Since decreased concentrations of artemether, dihydroartemisinin, or lumefantrine may result in a decrease of antimalarial efficacy, caution is recommended when Atripla and artemether/lumefantrine tablets are co-administered.
Croatian: Budući da smanjene koncentracije artemetera, dihidroartemisinina ili lumefantrina mogu imati za posljedicu smanjenu antimalarijsku djelotvornost, preporučuje se oprez pri istodobnoj primjeni Atriple i artemeter/lumefantrin tableta.
English: They include some common medicines and some herbal preparations (including St. John's wort) which can cause serious interactions.
Croatian: Među njima su neki lijekovi koji se često uzimaju i neki biljni pripravci (uključujući gospinu travu) koji mogu uzrokovati ozbiljne interakcije.
English: Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Croatian: Znakovi osteonekroze su ukočenost zglobova, bolovi (osobito u kuku, koljenu i ramenu) te otežano gibanje.
English: Efavirenz, one of the active components of Atripla, may remain in your blood for a time after therapy is stopped.
Croatian: Efavirenz, jedna od djelatnih tvari lijeka Atriple, može se zadržati u krvi određeno vrijeme nakon prekida liječenja.
English: The biliary hyperplasia regressed upon cessation of dosing.
Croatian: Bilijarna hiperplazija povukla se nakon prestanka davanja doza.
English: The bone toxicity in young adult rats and dogs occurred at exposures ≥ 5-fold the exposure in paediatric or adult patients; bone toxicity occurred in juvenile infected monkeys at very high exposures following subcutaneous dosing (≥ 40-fold the exposure in patients).
Croatian: U mladih odraslih štakora i pasa toksičnost za kosti pokazala se pri izloženosti dozi ≥ 5 puta većoj od izloženosti kod pedijatrijskih ili odraslih bolesnika; toksičnost za kosti pojavila se u mladih zaraženih majmuna pri vrlo visokim izloženostima nakon supkutanog doziranja (≥ 40 puta veća izloženost nego u bolesnika).
English: Efavirenz may be an inducer of CYP2C19 and CYP2C9; however, inhibition has also been observed in vitro and the net effect of co-administration with substrates of these enzymes is not clear (see section 5.2).
Croatian: Efavirenz može biti induktor CYP2C19 i CYP2C9; međutim in vitro je opažena i inhibicija pa neto učinak istodobne primjene sa supstratima ovih enzima nije jasan (vidjeti dio 5.2).
English: Darunavir/ritonavir should be used with caution in combination with Atripla.
Croatian: Darunavir/ritonavir trebaju se uzimati pažljivo u kombinaciji s Atriplom.
English: Dosing at bedtime seems to improve the tolerability of these symptoms (see section 4.2).
Croatian: Izgleda da davanje doze prije spavanja povećava podnošljivost tih simptoma (vidjeti dio 4.2).
English: If appropriate, resumption of antihepatitis B therapy may be warranted.
Croatian: Ako je to prikladno, može biti opravdano nastaviti terapiju za hepatitis B.
English: Some patients accidentally taking 600 mg efavirenz twice daily have reported increased nervous system symptoms.
Croatian: U nekih su bolesnika, koji su slučajno uzeli 600 mg efavirenza dva puta dnevno, uočeni pojačani simptomi na živčanom sustavu.
English: Limited data suggest there is no clinically significant effect on valproic acid pharmacokinetics.
Croatian: Ograničeni podaci ukazuju da nema klinički značajnog učinka na farmakokinetiku valproične kiseline.
English: Severe hepatic impairment (CPT, Class C) (see section 5.2).
Croatian: Teško oštećenje jetre (CPT, stadij C) (vidjeti dio 5.2).
English: 1 The predominant circulating metabolite of sofosbuvir.
Croatian: 1 Glavni metabolit sofosbuvira u cirkulaciji.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
Croatian: U slučaju istodobne antivirusne terapije hepatitisa B ili C, potrebno je također pročitati sažetak opisa svojstava lijeka za te lijekove.
English: There have also been post-marketing reports of severe depression, death by suicide, delusions, psychosis-like behaviour, and catatonia.
Croatian: Iz razdoblja nakon stavljanja lijeka u promet postoje izvješća o teškoj depresiji, samoubojstvu, halucinacijama, ponašanju sličnome psihozi i katatoniji.
English: As a result, the amounts of Atripla or other medicines in your blood may be affected.
Croatian: Kao rezultat toga može doći do utjecaja na količine Atriple i drugih lijekova u Vašoj krvi.
English: If you accidentally take too many Atripla tablets you may be at increased risk of experiencing possible side effects with this medicine (see section 4, Possible side effects).
Croatian: Ako ste slučajno uzeli previše tableta Atriple, možete biti izloženi povećanom riziku od nuspojava povezanih s ovim lijekom (pogledajte dio 4, Moguće nuspojave).
English: The breakdown of muscle, softening of the bones (with bone pain and sometimes resulting in fractures), muscle pain, muscle weakness and decreases in potassium or phosphate in the blood may occur due to damage to kidney tubule cells.
Croatian: Propadanje mišića, omekšavanje kostiju (uz bolove u kostima i ponekad posljedičnim prijelomima), bolovi u mišićima, slabost mišića i smanjenje kalija ili fosfata u krvi može nastati zbog oštećenja stanica bubrežnih kanalića.
English: Emtricitabine triphosphate and tenofovir diphosphate competitively inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.
Croatian: Emtricitabin trifosfat i tenofovir difosfat kompetitivno inhibiraju HIV-1 reverznu transkriptazu, što rezultira prekidom lanca DNK.
English: Dose adjustments of the immunosuppressant may be required.
Croatian: Možda će biti potrebno prilagođavanje doze imunosupresiva.
English: Efavirenz: no clinically significant interaction.
Croatian: efavirenz: ne postoji klinički značajna interakcija.
English: Rare renal failure (acute and chronic), acute tubular necrosis, nephritis (including acute interstitial nephritis)4, nephrogenic diabetes insipidus
Croatian: Rijetko zatajenje bubrega (akutno i kronično), akutna tubularna nekroza, nefritis (uključujući akutni intersticijski nefritis)4, nefrogeni dijabetes insipidus
English: If you forget to take Atripla
Croatian: Ako ste zaboravili uzeti Atriplu
English: Atripla in combination with darunavir/ritonavir 800/100 mg once daily may result in suboptimal darunavir Cmin.
Croatian: darunavirom/ritonavirom 800/100 mg jedanput na dan može rezultirati suboptimalnim Cmin darunavira.
English: Do not wait until your next dose is due.
Croatian: Nemojte čekati da stigne vrijeme za uzimanje sljedeće tablete.
English: The clinical significance of these changes in clarithromycin plasma levels is not known.
Croatian: Nije poznat klinički značaj promjena razina klaritromicina u plazmi.
English: Common cerebellar coordination and balance disturbances3, somnolence (2.0%)3, headache (5.7%)3, disturbance in attention (3.6%)3, dizziness dizziness headache
Croatian: Često cerebelarni poremećaji koordinacije i ravnoteže3, somnolencija (2,0%)3, glavobolja (5,7%)3, poremećaj pozornosti (3,6%)3, omaglica (8,5%)3
English: High density polyethylene (HDPE) bottle with a polypropylene child-resistant closure containing 30 film-coated tablets and silica gel desiccant.
Croatian: Boca od polietilena visoke gustoće (HDPE) s polipropilenskim sigurnosnim zatvaračem za djecu, koja sadrži 30 filmom obloženih tableta i silikagel kao sredstvo za sušenje.
English: 2 Thymidine analogue associated mutations included D67N (n=1) and K70R (n=1).
Croatian: 2 Mutacije povezane s analogom timidina uključivale su D67N (n=1) i K70R (n=1).
English: Following intravenous administration the volume of distribution of tenofovir was approximately 800 ml/kg.
Croatian: Nakon intravenske primjene volumen distribucije tenofovira bio je približno 800 ml/kg.
English: Nervous system symptoms: Nervous system symptoms are common with efavirenz, one of the components of Atripla.
Croatian: Simptomi živčanog sustava: Simptomi živčanog sustava česti su kod efavirenza, jedne od komponenti Atriple.
English: Atripla is a treatment for Human Immunodeficiency Virus (HIV) infection in adults aged 18 years and over who have previously been treated with other antiretroviral medicines and have their HIV-1 infection under control for at least three months.
Croatian: Atripla je namijenjena za liječenje infekcije virusom humane imunodeficijencije (HIV) odraslih osoba u dobi od 18 godina i više koje su prethodno bile liječene drugim antiretrovirusnim lijekovima i njihova je infekcija virusom HIV-1 pod kontrolom najmanje tri mjeseca.
English: The clinical implications of such an association are unknown; however, the potential for an increased frequency and severity of efavirenz-associated adverse events cannot be excluded.
Croatian: Kliničke implikacije takve veze nisu poznati, međutim ne može se isključiti potencijal za povećanu učestalost i težinu nuspojava povezanih s efavirenzom.
English: - Ginkgo biloba extracts (herbal preparation).
Croatian: - Ekstrakt Ginkgo bilobe (biljni pripravak).
English: Rare osteomalacia (manifested as bone pain and infrequently contributing to fractures)2,4, myopathy2
Croatian: Rijetko osteomalacija (koja se očituje bolovima u kostima i rijetko pridonosi prijelomima)2,4, miopatija2
English: Do not use this medicine after the expiry date which is stated on the bottle and carton after {EXP}.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na boci i kutiji iza oznake {Rok valjanosti}.
English: The pharmacokinetics of emtricitabine and tenofovir are similar in male and female patients.
Croatian: Farmakokinetike emtricitabina i tenofovira slične su u bolesnika muškog i ženskog spola.
English: Appropriate antihistamines and/or corticosteroids may improve tolerability and hasten the resolution of rash.
Croatian: Odgovarajući antihistaminici i/ili kortikosteroidi mogu poboljšati podnošljivost i ubrzati nestajanje osipa.
English: It is important not to miss a dose of Atripla.
Croatian: Važno je da ne propustite uzeti dozu Atriple.
English: Limited data suggest that Asian and Pacific Island patients may have higher exposure to efavirenz but they do not appear to be less tolerant of efavirenz.
Croatian: Ograničeni podaci ukazuju da je u bolesnika s područja Azije i pacifičkog otočja možda prisutna veća izloženost efavirenzu, ali ne čini se da u tih bolesnika postoji manja tolerancija na efavirenz.
English: Therefore, you should continue to use contraceptive measures, as above, for 12 weeks after you stop taking Atripla.
Croatian: Iz tog razloga trebate nastaviti s poduzimanjem gore navedenih mjera kontracepcije još 12 tjedana nakon prestanka uzimanja Atriple.
English: - Sertraline, a medicine used to treat depression, as your doctor may need to change your dose of sertraline.
Croatian: - Sertralin, lijek koji se koristi za liječenje depresije; liječnik će Vam možda morati promijeniti dozu sertralina.
English: Substantial decrease in lopinavir exposure, necessitating dosage adjustment of lopinavir/ritonavir.
Croatian: Značajno smanjenje izloženosti lopinaviru zbog koje je nužno prilagođavanje doze lopinavira/ritonavira.
English: Approximately 14 to 34% of a radiolabelled dose of efavirenz was recovered in the urine and less than 1% of the dose was excreted in urine as unchanged efavirenz.
Croatian: Približno 14 do 34% radioaktivno označene doze efavirenza izolirano je u mokraći, a manje od 1% doze izlučeno je mokraćom u obliku nepromijenjenog efavirenza.
English: After oral administration, emtricitabine is widely distributed throughout the body.
Croatian: Nakon peroralne primjene, emtricitabin je bio široko distribuiran cijelim tijelom.
English: If you see any signs of a severe rash with blistering or fever, stop taking Atripla and tell your doctor at once.
Croatian: Primijetite li bilo kakve znakove teškog osipa s mjehurima ili vrućicom, odmah prestanite s uzimanjem Atriple i obratite se svojem liječniku.
English: In vitro binding of tenofovir to human plasma or serum protein is < 0.7% and 7.2%, respectively over the tenofovir concentration range 0.01 to 25 µg/ml.
Croatian: In vitro vezivanje tenofovira na proteine ljudske plazme ili seruma je < 0,7%, odnosno 7,2%, u rasponu koncentracija tenofovira od 0,01 do 25 µg/ml.
English: However, tenofovir disoproxil reduced the viability index and weight of pups in peri-postnatal toxicity studies at maternally toxic doses.
Croatian: Ipak, tenofovirdizoproksil smanjio je indeks preživljenja i težinu mladunčadi u perinatalnim i postnatalnim ispitivanjima toksičnosti pri dozama toksičnim za majku.
English: Exposures of raltegravir (a UGT1A1 substrate) are reduced in the presence of efavirenz (see section 4.5, Table 1).
Croatian: Izloženost raltegraviru (supstratu UGT1A1) smanjena je u prisutnosti efavirenza (vidjeti dio 4.5, tablica 1).
English: Atripla should be avoided in patients with HIV-1 harbouring the K65R, M184V/I or K103N mutation (see sections 4.1 and 5.1).
Croatian: Primjenu Atriple treba izbjegavati u bolesnika inficiranih virusom HIV-1 s mutacijama K65R, M184V/I ili K103N (vidjeti dio 4.1 i 5.1).
English: Do not breast-feed during treatment with Atripla.
Croatian: Nemojte dojiti tijekom liječenja Atriplom.