FrancophonIA/ELRC3.0 huggingface dataset:
English: Hypersensitivity-type reactions, including skin rash, urticaria, angioedema, dyspnoea, erythaema, flushing, and hypotension occurred on initial or subsequent treatment with pegfilgrastim (uncommon
Slovenian: Med začetnim ali nadaljnjim zdravljenjem s pegfilgrastimom so se pojavile reakcije preobčutljivostne vrste, vključno z izpuščajem na koži, urtikarijo, angioedemom, dispnejo, eritemom, zardevanjem in hipotenzijo (občasni [≥ 1/1.000 do < 1/100]).
English: Step 4: Finish A Discard the used pre-filled syringe and other supplies in a sharps disposal container.
Slovenian: A Zavrzite uporabljeno injekcijsko brizgo in drugo opremo v vsebnik za ostre odpadke.
English: Due to the potential sensitivity of rapidly dividing myeloid cells to cytotoxic chemotherapy‚ Pegfilgrastim Mundipharma should be administered at least 24 hours after administration of cytotoxic chemotherapy.
Slovenian: 4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Zaradi možne občutljivosti hitro se delečih mieloidnih celic za citotoksično kemoterapijo je treba zdravilo Pegfilgrastim Mundipharma dati vsaj 24 ur po aplikaciji citotoksične kemoterapije.
English: - you are allergic to pegfilgrastim, filgrastim, E. coli derived proteins, or any of the other ingredients of this medicine.
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Pegfilgrastim Mundipharma Ne uporabljajte zdravila Pegfilgrastim Mundipharma - če ste alergični na pegfilgrastim, filgrastim, beljakovine, ki izvirajo iz E. coli, ali katero koli sestavino tega zdravila.
English: A small (n = 83), Phase II, randomised, double-blind study in patients receiving chemotherapy for de novo acute myeloid leukaemia compared pegfilgrastim (single dose of 6 mg) with filgrastim, administered during induction chemotherapy.
Slovenian: faze pri bolnikih, ki so dobivali kemoterapijo zaradi de novo akutne mieloidne levkemije, je primerjala pegfilgrastim (enkraten odmerek 6 mg) s filgrastimom ob aplikaciji med indukcijsko kemoterapijo.
English: Elevations in lactate dehydrogenase and alkaline phosphatase1; Transient elevations in LFT's for ALT or AST1 1 See section “Description of selected adverse reactions” below.
Slovenian: Preiskave zvišanje laktatdehidrogenaze in alkalne fosfataze1, prehodno zvišanje jetrnih funkcijskih testov za ALT ali
English: Do not grasp the needle cap.
Slovenian: Ne primite brizge za pokrovček igle.
English: Τηλ: +357 22 815656
Slovenian: Tel: +386 158969 00
English: Grab here
Slovenian: Primite tukaj zdravilo
English: (VAdriaC/IE) chemotherapy, a longer duration of severe neutropenia (neutrophils < 0.5 × 109) was observed in younger children aged 0-5 years (8.9 days) compared to older children aged 6-11 years and 12-21 years (6 days and 3.7 days, respectively) and adults.
Slovenian: faze pri pediatričnih bolnikih s sarkomom (n = 37), ki so dobili 100 μg/kg pegfilgrastima po 1. ciklusu kemoterapije z vinkristinom, doksorubicinom in ciklofosfamidom (VAdriaC/IE), so pri mlajših otrocih, starih od 0 do 5 let, ugotovili dolgotrajnejšo hudo nevtropenijo (nevtrofilci < 0,5 x 109) (8,9 dni) kot pri starejših otrocih, starih od 6 do 11 let (6 dni) in 12 do 21 let (3,7 dni) in pri odraslih.
English: Each pre-filled syringe contains 6 mg of pegfilgrastim in 0.6 mL (10 mg/mL) solution for injection.
Slovenian: NAVEDBA ENE ALI VEČ UČINKOVIN Ena napolnjena injekcijska brizga vsebuje 6 mg pegfilgrastima v 0,6 ml (10 mg/ml) raztopine za injiciranje.
English: This may be a sign of a problem with your spleen (splenomegaly) - if you have recently had a serious lung infection (pneumonia), fluid in the lungs (pulmonary oedema), inflammation of the lungs (interstitial lung disease) or an abnormal chest x-ray (lung infiltration) - if you are aware of any altered blood cell counts (e.g. increase in white blood cells or anaemia) or decreased blood platelet counts, which reduces the ability of your blood to clot (thrombocytopenia).
Slovenian: - če ste seznanjeni z morebitnimi spremembami števila krvnih celic (npr. s povečanjem števila belih krvničk ali anemijo) ali z zmanjšanim številom krvnih ploščic v krvi, kar zmanjša sposobnost strjevanja krvi (trombocitopenija).
English: Capillary leak síndrome
Slovenian: Sindrom kapilarne prepustnosti
English: You may take Pegfilgrastim Mundipharma out of the refrigerator and keep it at room temperature (not above 30° C) for no longer than 4 days.
Slovenian: Zdravilo Pegfilgrastim Mundipharma smete vzeti iz hladilnika in ga hraniti pri sobni temperaturi (pod
English: Injection site reactions, including injection site erythaema (uncommon) as well as injection site pain (common) have occurred on initial or subsequent treatment with pegfilgrastim.
Slovenian: Med začetnim ali nadaljnjim zdravljenjem s pegfilgrastimom so se pojavile reakcije na mestu injiciranja, vključno z eritemom na mestu injiciranja (občasni) in tudi bolečino na mestu injiciranja (pogosti).
English: /kg), the mean duration of grade 4 neutropenia for the pegfilgrastim group was 1.7 days, compared with 1.8 days in the filgrastim group (difference 0.03 days, 95 % CI
Slovenian: V drugi študiji (n = 310), v kateri so uporabljali za telesno maso popravljen odmerek (100 μg/kg), je bilo srednje trajanje nevtropenije 4. stopnje v skupini s pegfilgrastimom 1,7 dni, v skupini s filgrastimom pa 1,8 dni (razlika 0,03 dneva, 95 % IZ je -0,36, 0,30).
English: The incidence of hospitalisations and IV anti-infective use associated with a clinical diagnosis of febrile neutropenia was lower in the pegfilgrastim group compared with placebo (1 % versus 14 %, p < 0.001; and 2 % versus 10 %, p < 0.001).
Slovenian: kot med prejemnicami placeba (1 % v primerjavi s 14 %, p < 0,001, ter 2 % v primerjavi z 10 %,
English: Medicine
Slovenian: Dojenje
English: Respiratory Distress Syndrome2; Pulmonary adverse reactions (interstitial pneumonia, pulmonary oedema, pulmonary infiltrates and pulmonary fibrosis) Haemoptysis
Slovenian: (intersticijska pljučnica, pljučni edem, pljučni infiltrati in pljučna fibroza),
English: Hydrochloric acid (for pH adjustment) Sodium hydroxide (for pH adjustment) *Sodium acetate is prepared by mixing sodium acetate trihydrate and acetic acid.
Slovenian: * Natrijev acetat je pripravljen z mešanjem natrijevega acetata trihidrata in ocetne kisline.
English: Renal impairment
Slovenian: Valj brizge
English: Sickle cell crisis2;
Slovenian: srpastocelična kriza2, splenomegalija2,
English: 13 % of pegfilgrastim-treated patients compared with 20 % of filgrastim-treated patients (difference 7
Slovenian: V celotni študiji je bila pogostost febrilne nevtropenije pri bolnikih, zdravljenih s pegfilgrastimom, 13 %, pri bolnikih, zdravljenih s filgrastimom, pa 20 % (razlika 7 %, 95 % IZ je -19 %, 5 %).
English: Injection site pain,
Slovenian: raztopina za injiciranje
English: Non-cardiac chest pain 1
Slovenian: ki ne izvira od srca1
English: Mundipharma Pharmaceuticals B.V. Tel: + 31 (0)33 450 82 70 info@mundipharma.nl
Slovenian: Tel: + 31 (0)33 450 82 70 info@mundipharma.nl
English: White blood cell (WBC) counts of 100 × 109/L or greater have been observed in less than 1 % of patients receiving pegfilgrastim therapy.
Slovenian: Pri manj kot 1 % bolnikov, ki prejemajo terapijo s pegfilgrastimom, so opazili število belih krvničk, ki je enako 100 x 109/l ali večje.
English: Pegfilgrastim Mundipharma 6 mg solution for injection pegfilgrastim
Slovenian: Pegfilgrastim Mundipharma 6 mg raztopina za injiciranje pegfilgrastim
English: The overall rate of febrile neutropenia was 9 % of patients treated with pegfilgrastim and
Slovenian: Celotna pogostost febrilne nevtropenije je bila pri bolnikih, zdravljenih s pegfilgrastimom, 9 %, pri bolnikih, zdravljenih s filgrastimom, pa 18 % (razlika 9 %, 95 % IZ je
English: StevensJohnson syndrome
Slovenian: Sweetov sindrom
English: Blood and lymphatic system Disorders
Slovenian: Bolezni krvi in limfatičnega sistema trombocitopenija1 levkocitoza1
English: Common side effects (may affect up to 1 in 10 people): - pain at the site of injection.
Slovenian: Pogosti neželeni učinki (pojavijo se lahko pri največ 1 od 10 bolnikov): - bolečina na mestu injiciranja - splošne bolečine ter bolečine v sklepih in mišicah
English: Tabulated list of adverse reactions
Slovenian: pljučne neželene reakcije
English: Polysorbate 20 Water for injections
Slovenian: polisorbat 20 voda za injekcije klorovodikova kislina (za uravnavanje pH) natrijev hidroksid (za uravnavanje pH)
English: Respiratory, thoracic and mediastinal disorders
Slovenian: Bolezni dihal, prsnega koša in mediastinalnega prostora sindrom akutne dihalne stiske2,
English: STATEMENT OF ACTIVE SUBSTANCE(S)
Slovenian: FARMACEVTSKI PODATKI 6.1 Seznam pomožnih snovi natrijev acetat*
English: Do not attempt to remove the clear pre-filled syringe safety guard from the pre-filled syringe Do not attempt to remove the peelable label on the pre-filled syringe barrel before administering your injection.
Slovenian: Ne poskušajte odstraniti prozornega varnostnega ščitnika z napolnjene injekcijske brizge.
English: PharmaKorell GmbH Marie-Curie-Str. 8
Slovenian: PharmaKorell GmbH Marie-Curie-Str. 8 79539 Loerrach Nemčija
English: Bone pain Musculoskeletal pain (myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain)
Slovenian: Bolezni mišičnoskeletnega sistema in vezivnega tkiva bolečina v kosteh mišično-skeletna bolečina (mialgija,
English: Talk to your doctor, pharmacist or nurse before using Pegfilgrastim Mundipharma:
Slovenian: Pred začetkom uporabe zdravila Pegfilgrastim Mundipharma se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro:
English: Pegfilgrastim Mundipharma 6 mg pegfilgrastim
Slovenian: IME ZDRAVILA IN POT(I) UPORABE Pegfilgrastim Mundipharma 6 mg pegfilgrastim s.c.
English: Pegfilgrastim Mundipharma 6 mg solution for injection in pre-filled syringe
Slovenian: Pegfilgrastim Mundipharma 6 mg raztopina za injiciranje v napolnjeni injekcijski brizgi
English: - swelling or puffiness, which may be associated with passing water less frequently, difficulty breathing, abdominal swelling and feeling of fullness, and a general feeling of tiredness.
Slovenian: oteklost trebuha in občutek polnosti ter splošen občutek utrujenosti.
English: Pegfilgrastim Mundipharma 6 mg solution for injection in pre-filled syringe pegfilgrastim
Slovenian: Pegfilgrastim Mundipharma 6 mg raztopina za injiciranje v napolnjeni injekcijski brizgi pegfilgrastim
English: Your doctor may decide that it would be more convenient for you to inject Pegfilgrastim Mundipharma yourself.
Slovenian: Samoinjiciranje zdravila Pegfilgrastim Mundipharma Mogoče se bo zdravnik odločil, da bi bilo za vas prikladneje, če si zdravilo Pegfilgrastim
English: Pegfilgrastim Mundipharma
Slovenian: Shranjevanje zdravila Pegfilgrastim Mundipharma
English: Splenomegaly2; Splenic rupture2
Slovenian: ruptura vranice2
English: Uncommon elevations in liver function tests (LFTs) for ALT (alanine aminotransferase) or AST
Slovenian: Občasno so se bolnikom, ki so po citotoksični kemoterapiji dobili pegfilgrastim, pojavila zvišanja jetrnih funkcijskih testov za ALT (alanin-aminotransferaze) ali AST (aspartat-aminotransferaze).
English: - damage to the tiny filters inside your kidneys (glomerulonephritis).
Slovenian: - kožni vaskulitis (vnetje krvnih žil v koži) - okvara drobnih filtrov v ledvicah (glomerulonefritis) - pordelost na mestu injiciranja - izkašljevanje krvi (hemoptiza)
English: info@mundipharma.com.cy info@mundipharma.se
Slovenian: info@medisadria.hr
English: Used plunger
Slovenian: Uporabljeni valj brizge
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA za enkratno uporabo za subkutano uporabo
English: Pegfilgrastim Mundipharma contains sorbitol (E 420) and sodium acetate This medicine contains 30 mg sorbitol in each pre-filed syringe which is equivalent to 50 mg / mL.
Slovenian: Zdravilo Pegfilgrastim Mundipharma vsebuje sorbitol (E 420) in natrijev acetat
English: Mundipharma Pharmaceuticals Ltd
Slovenian: Mundipharma Pharmaceuticals B.V.
English: Mundipharma Biologics
Slovenian: DRUGI PODATKI Mundipharma
English: What you need to know before you use Pegfilgrastim Mundipharma
Slovenian: Kaj je zdravilo Pegfilgrastim Mundipharma in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Pegfilgrastim Mundipharma Kako uporabljati zdravilo Pegfilgrastim Mundipharma Možni neželeni učinki
English: info@mundipharma.at
Slovenian: info@egis.lv
English: (difference 0.23 days, 95 % CI −0.15, 0.63).
Slovenian: 17 %, p < 0,001).
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER PACK WITH SYRINGE
Slovenian: PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
English: The safety and efficacy of Pegfilgrastim Mundipharma have not been evaluated in patients receiving chemotherapy associated with delayed myelosuppression e.g., nitrosoureas.
Slovenian: Pri bolnikih, ki dobivajo kemoterapijo, povezano z odloženo mielosupresijo, na primer nitrozouree, varnosti in učinkovitosti zdravila Pegfilgrastim Mundipharma niso ovrednotili.
English: You can use:
Slovenian: Zdravilo lahko injicirate v:
English: Guide to parts
Slovenian: Sestavni deli
English: Unless your doctor directs you otherwise, you must stop breast-feeding if you use Pegfilgrastim Mundipharma.
Slovenian: Če uporabljate zdravilo Pegfilgrastim Mundipharma, morate prenehati dojiti, razen če vam zdravnik ne naroči drugače.
English: Stop using Pegfilgrastim Mundipharma and seek medical attention immediately if you notice any of the symptoms described in section 4.
Slovenian: Če opazite katerega od simptomov, opisanih v poglavju 4, prenehajte uporabljati zdravilo Pegfilgrastim Mundipharma in nemudoma poiščite zdravniško pomoč.
English: Upper arm
Slovenian: Oprijemalo za prste
English: post@mundipharma.no
Slovenian: info@medis.si
English: Step 3: Inject A Hold the pinch.
Slovenian: 3. korak: Injiciranje
English: Each pre-filled syringe contains 6 mg of pegfilgrastim in - 0.6 mL of solution.
Slovenian: Ena napolnjena injekcijska brizga vsebuje 6 mg pegfilgrastima v
English: Finger grips Syringe label Syringe barrel
Slovenian: nadlaket trebuh zgornji del stegna
English: Step 4 Use according to 4a or 4b recommendation:
Slovenian: Korak 4 Uporabite glede na 4a ali 4b priporočila:
English: It also possesses repellent properties.
Slovenian: Ima tudi repelentne lastnosti.
English: ATCvet code: QP53AC54.
Slovenian: Oznaka ATC vet: QP53AC54.
English: Do not use on cats (see ‘Special warnings').
Slovenian: Ne uporabite za mačke (glejte poglavje 'Posebna opozorila').
English: Ceva Santé Animale 10, av. de La Ballastière 33500 Libourne FRANCE
Slovenian: Ceva Santé Animale 10, av. de La Ballastière 33500 Libourne Francija
English: MARKETING AUTHORISATION NUMBER(S) EU/2/13/156/001-035
Slovenian: ŠTEVILKA(E) DOVOLJENJ(A) ZA PROMET EU/2/13/156/001-035
English: Do not use on cats.
Slovenian: Ne uporabite pri mačkah.
English: Date of latest renewal: 27/08/2018
Slovenian: Datum zadnjega podaljšanja dovoljenja za promet: 27/08/2018
English: SPECIAL WARNING(S), IF NECESSARY Do not use on cats.
Slovenian: POSEBNO(A) OPOZORILO(A), ČE JE/SO POTREBNO(A) Ne uporabite pri mačkah.
English: • Avoid contact with the skin.
Slovenian: • Izogibajte se stiku s kožo.
English: Part the hair until the skin is visible.
Slovenian: Razmaknite dlako, da bo vidna koža.
English: 4.8 Interaction with other medicinal products and other forms of interaction None known.
Slovenian: 4.8 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij
English: • Wash hands thoroughly and immediately after use.
Slovenian: • Takoj po uporabi si temeljito umijte roke.
English: To avoid adverse reactions:
Slovenian: V izogib neželenim učinkom:
English: It is therefore recommended to treat dogs in the evening, or before taking them for a walk.
Slovenian: Zato je priporočljivo zdravilo nanesti zvečer ali pred sprehodom.
English: This prevents infestation within the environment of the treated animal.
Slovenian: To prepreči okužbo okolja zdravljene živali.
English: Children should avoid contact with the dog during 4 hours after treatment.
Slovenian: Otroci se morajo izogibati stiku s psom 4 ure po zdravljenju.
English: The periodic safety update report (PSUR) cycle should be restarted for submission of 6 monthly reports (covering all authorised presentations of the product) for the next two years, followed by yearly reports for the subsequent two years and thereafter at 3 yearly intervals.
Slovenian: Cikel rednih posodobljenih poročil o varnosti zdravila (PSUR) se ponovno začne z oddajo šestmesečnih poročil (vključene so vse odobrene oblike zdravila) v obdobju naslednjih dveh let, ki mu sledi oddaja dveh letnih poročil za naslednji dve leti, po tem obdobju pa se poročila oddajajo v triletnih obdobjih.
English: Pyriproxyfen is a photostable insect growth regulator (IGR).
Slovenian: Piriproksifen je fotostabilen regulator rasti insektov (IGR).
English: For this reason the transmission of infectious diseases cannot be completely excluded if conditions are favourable.
Slovenian: Zato v ustreznih okoliščinah ni možno popolnoma izključiti prenosa kužnih bolezni.
English: • On the day of treatment, treated dogs should not be permitted to sleep with their owners, especially children.
Slovenian: • Na dan nanosa, naj psi ne spijo pri lastnikih, še posebno ne pri otrocih.
English: To remove ticks, it is recommended to use an appropriate tick removal device.
Slovenian: Za odstranitev klopov se priporoča odstranjevanje z ustrezno napravo za odstranjevanje klopov.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 04/12/2013
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 04/12/2013
English: This results in hyperexcitability and death of the parasite.
Slovenian: Rezultat je prekomerna vzdražljivost in smrt parazita.
English: Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency (http://www.ema.europa.eu/).
Slovenian: Podrobne informacije o tem zdravilu za uporabo v veterinarski medicini so na voljo na spletni strani Evropske agencije za zdravila (European Medicines Agency) (http://www.ema.europa.eu).
English: Step 3: The dog should be standing or in a comfortable position for easy application.
Slovenian: Korak 3: Pes naj stoji ali naj bo v udobnem položaju za enostaven nanos.
English: This will pierce the seal.
Slovenian: To bo prebodlo zapiralo.
English: Pale yellow solution.
Slovenian: Bledo rumena raztopina.
English: Flea eggs, larvae and pupae are present in the environment.
Slovenian: Jajčeca, ličinke in bube bolh so prisotne v okolju.
English: The treatment can be repeated once a month.
Slovenian: Nanos lahko ponovite enkrat mesečno.
English: In case of exposure of this type seek veterinary advice immediately.
Slovenian: V primeru izpostavitve takoj poiščite veterinarsko pomoč.
English: Spot-on applicator made of a multilayered complex of aluminium and polyethylene (PE) with HDPE, top-sealed with a liner complex (aluminium/polyester/sealable PE layer).
Slovenian: Kapalka vsebuje večslojni kompleks aluminija in polietilena (PE) iz HDPE, vrh je zatesnjen z linearnim kompleksom (aluminij/poliester/zatesnitveni PE sloj).
English: See also section "Special precautions for the disposal of unused product or waste materials".
Slovenian: Glejte tudi poglavje ''Posebni varnostni ukrepi za odstranjevanje neporabljenega zdravila ali odpadnih snovi''.
English: N-octyl-2-pyrrolidone
Slovenian: N-oktil-2-pirolidon
English: Dinotefuran is an insecticide.
Slovenian: Dinotefuran je insekticid.
English: Once bound to these receptors, the agonist action of repeated excitatory impulses kills the insect.
Slovenian: Po vezavi na te receptorje se sproži agonistična reakcija in stalni ekscitatorni impulzi ubijejo insekt.
English: Mechanisms of action:
Slovenian: Mehanizem delovanja:
English: People with known hypersensitivity to any of the ingredients should avoid contact with the veterinary medicinal product.
Slovenian: Osebe z znano preobčutljivostjo na katero koli sestavino zdravila naj se izogibajo stiku z zdravilom.
English: The following table shows the size of spot-on applicator to be used according to the weight of the dog:
Slovenian: Naslednja tabela določa velikost kapalke, ki jo je potrebno uporabiti glede na maso psa:
English: The veterinary medicinal product remains effective when treated animals are immersed in water (e.g. swimming, bathing).
Slovenian: Zdravilo za uporabo v veterinarski medicini še naprej učinkuje, če se zdravljene živali zmočijo v vodi (npr. plavanje, kopanje).
English: Dinotefuran kills insects by targeting their nervous system.
Slovenian: Dinotefuran ubija insekte z delovanjem na njihov živčni sistem.
English: Step 2: With the other hand, press downwards on the smaller disk until the 2 disks meet evenly.
Slovenian: Korak 2: Z drugo roko pritisnite navzdol na manjši disk, dokler se oba diska enakomerno ne stikata.
English: Its structure is derived from the neurotransmitter acetylcholine and acts on nicotinic acetylcholine receptors of the insect nerve synapse.
Slovenian: Njegova struktura izhaja iz nevrotransmiterja acetilholina in deluje na nikotin acetilholinske receptorje v živčnih sinapsah insekta.
English: The three active substances rapidly distribute over the body surface of the animal within the first day, with maximum concentrations obtained 3 days after the application.
Slovenian: Tri učinkovine se hitro razporedijo po površini telesa živali v prvem dnevu, maksimalno koncentracijo dosežejo 3 dni po nanosu.
English: Behavioural disorders such as hyperactivity, vocalisation or anxiety, systemic signs such as lethargy or anorexia, and neurological signs such as muscle tremor have been reported in rare cases.
Slovenian: Vedenjske motnje kot so hiperaktivnost, vokalizacija ali tesnobnost, sistemski znaki kot so letargija ali anoreksija in nevrološki znaki kot je mišični tremor so bili opaženi v redkih primerih.
English: Avoid contact of the product with your skin, eyes or mouth.
Slovenian: Izogibajte se stiku zdravila s kožo, očmi in usti.
English: Signs of ataxia such as unsteady movement have been reported in very rare cases.
Slovenian: Znaki ataksije, kot je nestabilno gibanje, so bili opaženi v zelo redkih primerih.
English: The anticipated clinical benefit resulting from a combination of dinotefuran with permethrin was demonstrated in one laboratory study on dogs which showed a prolongation of the duration of efficacy against C. canis fleas to 4 weeks.
Slovenian: Pričakovan klinično koristen učinek kombinacije dinotefurana s permetrinom je bil ugotovljen v laboratorijski študiji na psih, ki je pokazal podaljšano delovanje na bolhe C. canis do 4 tednov.
English: Pyrethroids act as neurotoxins on voltage-gated sodium channels by slowing their activation and inactivation properties.
Slovenian: Piretroidi delujejo kot nevrotoksini na napetostno občutljive natrijeve kanale tako, da upočasnijo njihove aktivacijske in neaktivacijske lastnosti.
English: It acts through contact, by mimicking the juvenile hormone, which regulates the moulting of insects from one life stage to the next.
Slovenian: Deluje preko kontakta tako, da oponaša juvenilni hormon, ki uravnava levitev insekta iz ene v drugo življenjsko obliko.
English: Dinotefuran has been shown to cross the blood-milk barrier and is excreted in the milk.
Slovenian: Dinotefuran lahko prestopi krvno-mlečno pregrado in se izloča v mleku.
English: In case of accidental exposure, if undesirable effects occur, wash the cat with shampoo or soap.
Slovenian: V primeru nenamernega izpostavljanja, če se pojavijo neželeni učinki, operite mačko s šamponom ali milom.
English: For permethrin, the plasma levels remain under the limit of quantification.
Slovenian: Za permetrin je nivo v plazmi pod mejo določljivega.
English: In case of massive flea infestation and at the beginning of the control measures, these areas should be treated with a suitable insecticide and then vacuumed regularly.
Slovenian: V primerih večje infestacije bolh in v začetku preventivnih ukrepov, je potrebno na takih mestih uporabiti ustrezna insekticidna sredstva ter redno sesati.