FrancophonIA/ELRC3.0 huggingface dataset:
English: Push the plastic adapter into the neck of the bottle
Croatian: Ugurajte plastični nastavak u grlo boce.
English: You need to know about important signs and symptoms to look out for while you are taking Ziagen.
Croatian: Zbog toga morate biti upoznati s važnim znakovima i simptomima na koje treba obratiti pozornost prilikom uzimanja lijeka Ziagen.
English: However, no effects on neuropsychological performance were seen when it was administered to patients with AIDS dementia complex.
Croatian: Međutim, nije uočen učinak na neuropsihološka svojstva kad je primijenjen bolesnicima s demencijom povezanom s AIDS-om.
English: It is not known whether abacavir can be removed by peritoneal dialysis or haemodialysis.
Croatian: Nije poznato može li se abakavir odstraniti peritonealnom dijalizom ili hemodijalizom.
English: Three subjects had undetectable viral load and one had plasmatic HIV-RNA of 900 copies/ml at Week 48.
Croatian: Tri su ispitanika imala nemjerljivo virusno opterećenje, a jedan je imao plazmatsku razinu HIV-RNK od 900 kopija/ml u 48. tjednu.
English: No firm conclusion could be drawn due to the limited data derived from this study.
Croatian: Zbog ograničenih podataka iz ove studije ne mogu se izvući čvrsti zaključci.
English: Additionally, the efficacy and safety of abacavir given once daily has been demonstrated in a pivotal clinical study (CNA30021See section 5.1 Clinical experience).
Croatian: Osim toga, djelotvornost i sigurnost abakavira primijenjenog jedanput na dan dokazana je i u pivotalnoj kliničkoj studiji (CNA30021- vidjeti dio 5.1.Kliničko iskustvo).
English: Potent enzymatic inducers such as rifampicin, phenobarbital and phenytoin may via their action on UDP-glucuronyltransferases slightly decrease the plasma concentrations of abacavir.
Croatian: Snažni induktori enzima poput rifampicina, fenobarbitona i fenitoina mogu svojim djelovanjem na UDP-glukuroniltransferaze blago smanjiti koncentracije abakavira u plazmi.
English: Twice Daily N (%)
Croatian: Dvaput na dan N (%)
English: Pharmacokinetic data were derived from 3 pharmacokinetic studies (PENTA 13, PENTA 15 and ARROW PK substudy) enrolling children under 12 years of age.
Croatian: Farmakokinetički podaci dobiveni su u 3 farmakokinetička ispitivanja (PENTA 13, PENTA 15 i farmakokinetičko podispitivanje u sklopu ispitivanja ARROW), u kojima su sudjelovala djeca mlađa od 12 godina.
English: Abacavir penetrates the cerebrospinal fluid (CSF) (see section 5.2), and has been shown to reduce HIV-1 RNA levels in the CSF.
Croatian: Abakavir prodire u cerebrospinalnu tekućinu (CSF) (vidjeti dio 5.2), te je dokazano da smanjuje količinu RNA HIV-1 u cerebrospinalnoj tekućini.
English: An oral solution (20 mg abacavir/ml) is also available for the treatment of children over three months of age and weighing less than 14 kg, or for people who need a lower than usual dose, or who cannot take tablets.
Croatian: Oralna otopina (20 mg abakavira/ml) je također dostupna za liječenje djece iznad 3 mjeseca starosti i težine manje od 14 kg, ili za djecu koja trebaju manje od uobičajene doze, ili koje ne mogu uzimati tablete.
English: Ziagen is also available as an oral solution for use in children over three months of age and weighing less than 14 kg and for those patients for whom the tablets are inappropriate.
Croatian: Ziagen je dostupan također u obliku oralne otopine za primjenu kod djece iznad 3 mjeseca starosti i težine manje od 14 kg i za bolesnike za koje tableta nije prikladna.
English: Once Daily N (%)
Croatian: Jedanput na dan N (%)
English: In vitro studies have demonstrated that its mechanism of action in relation to HIV is inhibition of the HIV reverse transcriptase enzyme, an event which results in chain termination and interruption of the viral replication cycle.
Croatian: Studije in vitro pokazuju da je njegov mehanizam djelovanja prema HIV-u inhibicija enzima reverzne transkriptaze HIV-a, koja dovodi do terminacije lanca i prekida replikacije virusnog ciklusa.
English: For many adverse reactions reported, it is unclear whether they are related to Ziagen, to the wide range of medicinal products used in the management of HIV infection or as a result of the disease process.
Croatian: Za mnoge prijavljene nuspojave nije jasno jesu li povezane sa lijekom Ziagen, velikim brojem drugih lijekova koji se koriste u liječenju HIV infekcije ili su posljedica bolesti.
English: People may be more likely to get this condition:
Croatian: Vjerojatnija je mogućnost da će bolesnici razviti to stanje:
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to CART.
Croatian: Iako se smatra da postoji više uzroka (uključujući primjenu kortikosteroida, uživanje alkohola, tešku imunosupresiju, veći indeks tjelesne mase), zabilježeni su slučajevi osteonekroze, osobito u bolesnika s uznapredovalom HIV infekcijom i/ili onih koji su dugo vremena izloženi CART-u.
English: 2 if you get symptoms from at least 2 of the following groups:
Croatian: 2 ako se pojave simptomi iz barem dvije od sljedećih grupa simptoma: - vrućica
English: There was no significant difference in the time to first virologic failure (p=0.73, log-rank test) between the 2 arms.
Croatian: Vrijeme do prve pojave virološkog neuspjeha se nije značajnije razlikovalo među skupinama (p = 0,73, log-rank test).
English: Your doctor may advise you to stop taking Ziagen.
Croatian: Vaš liječnik Vas može savjetovati da prestanete uzimati Ziagen.
English: Elderly No pharmacokinetic data are currently available in patients over 65 years of age.
Croatian: Starije osobe Farmakokinetički podaci u bolesnika starijih od 65 godina trenutno nisu dostupni.
English: Abacavir + lamivudine + PI (or PI/ritonavir)
Croatian: Abakavir + lamivudin + IP (ili IP/ritonavir)
English: The antiviral activity of abacavir in cell culture was not antagonized when combined with the nucleoside reverse transcriptase inhibitors (NRTIs) didanosine, emtricitabine, lamivudine, stavudine, tenofovir or zidovudine, the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, or the protease inhibitor (PI) amprenavir.
Croatian: Antivirusna aktivnost abakavira u kulturi stanica nije bila antagonizirana kad se primjenjivao u kombinaciji s nukleozidnim inhibitorima reverzne transkriptaze (NRTI) didanozinom, emtricitabinom, lamivudinom, stavudinom, tenofovirom ili zidovudinom, s nenukleozidnim inhibitorom reverzne transkriptaze (NNRTI) nevirapinom ili inhibitorom proteaze (PI) amprenavirom.
English: You should have been tested for this gene before Ziagen was prescribed for you.
Croatian: Trebali biste biti testirani za taj gen prije nego li će Vam Ziagen biti propisan kao terapija.
English: Ziagen oral solution contains 340 mg/ml of sorbitol.
Croatian: Ziagen oralna otopina sadrži 340 mg/ml sorbitola.
English: Median Change vRNA (log10 c/ml)
Croatian: Medijan promjene vRNK (log10 c/ml)
English: Discard oral solution two months after first opening.
Croatian: Odbaciti oralnu otopinu dva mjeseca nakon otvaranja.
English: P450 does not play a major role in the metabolism of abacavir, and abacavir does not inhibit metabolism mediated by CYP 3A4.
Croatian: P450 ne igra veliku ulogu u metabolizmu abakavira i abakavir ne pokazuje utjecaj na inhibiciju metabolizma posredovanog enzimom CYP 3A4.
English: In patients with high viral load (>100,000 copies/ml) the choice of a triple combination with abacavir, lamivudine and zidovudine needs special consideration (see section 5.1).
Croatian: U bolesnika s velikim brojem kopija virusa (>100 000 kopija/ml) treba posebno razmotriti mogućnost izbora trostruke terapije (abakavir, lamivudin i zidovudin) (vidjeti dio 5.1).
English: These findings should be considered for any child exposed in utero to nucleotide and nucleotide analogues, who presents with severe clinical findings of unknown etiology, particularly neurologic findings.
Croatian: Te nalaze treba uzeti u obzir u svakog djeteta koje je in utero bilo izloženo analozima nukleozida i nukleotida, a koje je imalo tešku kliničku sliku nepoznate etiologije, osobito neurološke nalaze.
English: IMPORTANT - ALERT CARD ZIAGEN (abacavir) oral solution Carry this card with you at all times
Croatian: VAŽNO - KARTICA S UPOZORENJEM ZIAGEN (abakavir) oralna otopina Ovu karticu uvijek nosite sa sobom
English: Virologic success (48 weeks HIV RNA < 50 copies/ml)
Croatian: Virološki uspjeh (48 tjedana HIV RNK < 50 kopija/ml)
English: Ziagen is also available as a tablet formulation.
Croatian: Ziagen je dostupan i u obliku tablete.
English: Plasma protein binding studies in vitro indicate that abacavir binds only low to moderately (~49%) to human plasma proteins at therapeutic concentrations.
Croatian: Studije o vezanju na proteine plazme in vitro pokazuju da se abakavir u terapijskim koncentracijama veže slabo do umjereno (∼49%) na ljudske proteine plazme.
English: Patients co-infected with chronic hepatitis B or C virus
Croatian: Bolesnici s istodobnom kroničnom infekcijom virusom hepatitisa B ili C
English: No definitive dose recommendation can be made in patients with mild hepatic impairment (Child-Pugh score 5-6).
Croatian: Ne može se dati konačna preporuka za doziranje u bolesnika s blagim oštećenjem jetre (Child-Pugh vrijednost 5-6 ).
English: Child-resistant foil blister packs (polyvinyl chloride/aluminium/paper) containing 60 tablets.
Croatian: Blister pakiranja sa folijom sigurnom za djecu (polivinilklorid/aluminij/papir) koja sadrže 60 tableta.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS TABLET BLISTER FOIL TEXT
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP TEKST ZA BLISTER TABLETA
English: To ensure administration of the entire dose, the tablet(s) should ideally be swallowed without crushing.
Croatian: Kako bi se osigurala primjena cjelokupne doze, tableta (tablete) se treba progutati cijela bez prethodnog drobljenja.
English: The remaining arms were continued in a blinded fashion.
Croatian: Preostale dvije skupine su nastavile sa slijepim liječenjem.
English: The pharmacokinetics of abacavir has not been studied in patients over 65 years of age.
Croatian: Farmakokinetika abakavira nije ispitivana u bolesnika starijih od 65 godina.
English: What Ziagen is and what it is used for Ziagen is used to treat HIV (human immunodeficiency virus) infection.
Croatian: Što je Ziagen i za što se koristi Ziagen je namijenjen liječenju infekcija HIV-om (virusom humane imunodeficijencije).
English: In heavily NRTI pretreated patients the efficacy of abacavir is very low.
Croatian: U bolesnika koji su prethodno intenzivno liječeni NRTI-ma, djelotvornost abakavira je vrlo mala.
English: Keep in touch with your doctor, and do not stop taking Ziagen without your doctor's advice.
Croatian: Ostanite u kontaktu sa svojim liječnikom i nemojte prestati uzimati Ziagen bez prethodnog savjetovanja sa svojim liječnikom.
English: When full, the syringe contains 10 ml of solution.
Croatian: Štrcaljka kad je puna sadrži 10 ml otopine.
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Croatian: Bolesnicima treba savjetovati da se jave liječniku ako primijete bolove u zglobovima, ukočenost zglobova ili poteškoće prilikom kretanja.
English: If you are hypersensitive to Ziagen, return all your unused Ziagen tablets for safe disposal.
Croatian: Ako ste preosjetljivi na Ziagen, vratite sve neiskorištene Ziagen tablete na sigurno odlaganje.
English: Typically, such reactions have been observed within the first few weeks or months of initiation of CART.
Croatian: Ovakve reakcije su tipično zabilježene u prvih nekoliko tjedana ili mjeseci nakon uvođenja kombiniranog antiretrovirusnog liječenja (CART).
English: This indicates a low likelihood for interactions with other medicinal products through plasma protein binding displacement.
Croatian: To ukazuje na nisku vjerojatnost interakcije lijekova putem kompetitivnog vezanja na proteine plazme.
English: The observed values of the peak concentrations are 9 fold greater than the IC50 of abacavir of 0.08 µg/ml or 0.26 µM when abacavir is given at 600 mg twice daily.
Croatian: Opažene vrijednosti vršnih koncentracija su 9 puta veće nego IC50 abakavira od 0,08 µg/ml ili 0,26 µM, kad se abakavir daje u dozi od 600 mg dvaput na dan.
English: The scored tablets are yellow and capsule-shaped and are provided in blister packs containing 60 tablets.
Croatian: Tablete s razdjelnom crtom su žute boje, u obliku kapsule i dostupne su u blister pakiranjima koja sadrže 60 tableta.
English: The safety and efficacy of Ziagen has not been established in patients with significant underlying liver disorders.
Croatian: Sigurnost i djelotvornost lijeka Ziagen nije ustanovljena u bolesnika sa značajnom osnovnom bolesti jetre.
English: 3 to 12 years (N=36)
Croatian: 3-12 godina (N=36)
English: If you get any symptoms of infection while you are taking Ziagen: Tell your doctor immediately.
Croatian: Ako zadobijete bilo koji od ovih simptoma infekcije prilikom uzimanja lijeka Ziagen: Odmah obavijestite svog liječnika.
English: The limited data available indicate that an oral solution dose of 2 mg/kg in neonates less than 30 days old provides similar or greater AUCs, compared to the 8 mg/kg oral solution dose administered to older children.
Croatian: Ograničeni dostupni podaci ukazuju da doza oralne otopine od 2 mg/kg u novorođenčadi mlađe od 30 dana omogućuje sličan ili veći AUC u usporedbi s dozom oralne otopine od 8 mg/kg koja se daje starijoj djeci.
English: The data are displayed in the table below:
Croatian: Ti su podaci prikazani u tablici u nastavku:
English: Based on the results of in vitro experiments and the known major metabolic pathways of abacavir, the potential for P450 mediated interactions with other medicinal products involving abacavir is low.
Croatian: Na temelju rezultata ispitivanja in vitro i poznatog glavnog metaboličkog puta abakavira, mogućnost za interakciju abakavira s drugim lijekovima posredovanu citokromom P450 je niska.
English: In vitro resistance
Croatian: Rezistencija in vitro
English: Some people taking Ziagen for HIV are more at risk of serious side effects.
Croatian: Neki bolesnici koji uzimaju Ziagen za HIV su pod višim rizikom od razvoja ozbiljnih nuspojava.
English: The overall selection frequency for M184V or M184I was high (54%), and less common was the selection of L74V (5%), K65R (1%) and Y115F (1%).
Croatian: Ukupna učestalost selekcije M184V ili M184I je bila visoka (54%), dok su manje česte bile selekcije L74V (5%), K65R (1%) i Y115F (1%).
English: People with advanced HIV infection (AIDS) have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Croatian: Bolesnici s uznapredovalom HIV infekcijom (AIDS) imaju oslabljen imunološki sustav te su skloniji razvoju ozbiljnih infekcija (tzv. oportunističkih infekcija).
English: If ABC hypersensitivity cannot be ruled out on clinical grounds, ABC should be permanently discontinued and should not be restarted, regardless of the results of HLA-B*5701 screening.
Croatian: U slučaju da se preosjetljivost na ABC ne može isključiti na temelju kliničkih dokaza, ABC se mora trajno isključiti iz terapije i ne smije se ponovno uvoditi, bez obzira na rezultate HLA-B*5701 probira.
English: In this study abacavir increased the mean methadone systemic clearance by 22%.
Croatian: U tom ispitivanju, abakavir je povećao srednju vrijednost sistemskog klirensa metadona za 22%.
English: The metabolites are excreted in the urine.
Croatian: Metaboliti se izlučuju u urin.
English: 240 ml oral solution
Croatian: 240 ml oralne otopine
English: Some medicines interact with Ziagen
Croatian: Neki lijekovi imaju interakciju s lijekom Ziagen
English: IMPORTANT - ALERT CARD ZIAGEN (abacavir) tablets Carry this card with you at all times
Croatian: VAŽNO - KARTICA S UPOZORENJEM ZIAGEN (abakavir) tablete Ovu karticu uvijek nosite sa sobom
English: When prescribing Ziagen, action should be taken to try to minimize all modifiable risk factors (e.g. smoking, hypertension, and hyperlipidaemia).
Croatian: Stoga kada propisujete Ziagen, potrebno je poduzeti mjere opreza kako bi se pokušalo minimizirati sve čimbenike rizika na koje se može utjecati (npr. pušenje, hipertenzija i hiperlipidemija).
English: This potential difference is sufficiently small to draw an overall conclusion of noninferiority of abacavir once daily over abacavir twice daily.
Croatian: Ta potencijalna razlika je dovoljno mala da se može donijeti konačan zaključak kako je doziranje abakavira jedanput na dan jednako vrijedno doziranju dvaput na dan.
English: If overdose occurs the patient should be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Croatian: U slučaju predoziranja bolesnika treba pratiti kako bi se uočili eventualni znakovi toksičnosti (vidjeti dio 4.8), te da bi se, ako je potrebno, primijenila standardna suportivna terapija.
English: • aches and pains (especially in the hip, knee or shoulder)
Croatian: • stalne tupe bolove i povremene jače bolove (posebice u kuku, koljenu i ramenu)
English: A fertility study in the rat has shown that abacavir had no effect on male or female fertility.
Croatian: Ispitivanja o fertilnosti u štakora pokazuju da abakavir nije imao utjecaja na fertilnost mužjaka ni ženki.
English: Hypersensitivity reactions can start at any time during treatment with Ziagen, but are more likely during the first 6 weeks of treatment.
Croatian: Reakcije preosjetljivosti mogu započeti u bilo koje vrijeme terapije lijekom Ziagen, no najčešće tijekom prvih 6 tjedana liječenja.
English: Children (weighing less than 25 kg):
Croatian: Djeca (tjelesne težine manje od 25 kg):
English: Rechallenge can result in a more rapid and severe reaction, which can be fatal, therefore rechallenge is contraindicated.
Croatian: Ponovno uvođenje ABC-a može rezultirati puno bržom i težom reakcijom, što može biti fatalno, stoga je ponovno uvođenje kontraindicirano.
English: If your doctor advises that you can start taking Ziagen again, you may be asked to take your first doses in a place where you will have ready access to medical care if you need it.
Croatian: Ako Vam je liječnik savjetovao da ponovno počnete uzimati Ziagen, možda će Vam reći da prve doze uzmete na mjestu gdje Vam se u slučaju potrebe odmah može ukazati liječnička pomoć.
English: Subgroup analyses testing for heterogeneity of once vs twice daily demonstrated no significant effect of sex, age, or viral load at randomisation.
Croatian: Analize podskupina u kojima se ispitivala heterogenost doziranja jedanput na dan naspram doziranja dvaput na dan nije ukazala na značajan učinak spola, dobi ni virusnog opterećenja pri randomizaciji.
English: Patients being treated with methadone and abacavir should be monitored for evidence of withdrawal symptoms indicating under dosing, as occasionally methadone re-titration may be required.
Croatian: U bolesnika koji se liječe metadonom i abakavirom treba pratiti eventualnu pojavu simptoma ustezanja koji ukazuju na premalo doziranje, jer u pojedinim slučajevima može biti potrebna ponovna titracija metadona.
English: Following oral administration, the mean time (tmax) to maximal serum concentrations of abacavir is about 1.5 hours for the tablet formulation and about 1.0 hour for the solution formulation.
Croatian: Nakon peroralne primjene, srednje vrijeme (tmax) u kojem se postiže maksimalna koncentracija abakavira u serumu je oko 1,5 sati za lijek u obliku tablete te približno 1,0 sat za lijek u obliku otopine.
English: • fever (high temperature) and skin rash
Croatian: • vrućica (visoka temperatura) i osip kože.
English: No definitive recommendation on dosage reduction is possible in patients with mild hepatic impairment due to the substantial variability of abacavir exposure.
Croatian: Ne može se dati konačna preporuka za redukciju doze u bolesnika s blagim oštećenjem jetre zbog znatnih varijacija u izloženosti abakaviru.
English: Important information about some of the other ingredients of Ziagen oral solution
Croatian: Važne informacije o nekim sastojcima Ziagen oralne otopine
English: Abacavir is not recommended in patients with moderate or severe hepatic impairment.
Croatian: Abakavir se ne preporučuje u bolesnika s umjerenim ili teškim oštećenjem jetre.
English: The safety and efficacy of Ziagen in a number of different multidrug combination regimens is still not completely assessed (particularly in combination with NNRTIs).
Croatian: Još nije u potpunosti ocijenjena sigurnost i djelotvornost lijeka Ziagen u brojnim kombinacijama s različitim lijekovima (osobito u kombinaciji s nenukleozidnim inhibitorima reverzne transkriptaze, NNRTI).
English: The pharmacokinetics of abacavir in patients with end-stage renal disease is similar to patients with normal renal function.
Croatian: Farmakokinetika abakavira u bolesnika s krajnjim stadijem bubrežne bolesti jednaka je kao u bolesnika s normalnom funkcijom bubrega.
English: Percent with <400 copies/ml vRNA
Croatian: Postotak s <400 kopija/ml vRNK
English: It is supplied in cartons containing a white polyethylene bottle, with a child resistant cap.
Croatian: Dolazi u kutiji koja sadrži bijelu polietilensku bocu sa sigurnosnim zatvaračem za djecu.
English: Studies in animals showed that abacavir had no effect on fertility (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su da abakavir ne utječe na plodnost (vidjeti dio 5.3).
English: Logistic regression modelling of the predictive value for genotype (adjusted for baseline plasma HIV-1 RNA [vRNA], CD4+ cell count, number and duration of prior antiretroviral therapies), showed that the presence of 3 or more NRTI resistance-associated mutations was associated with reduced response at Week 4 (p=0.015) or 4 or more mutations at median Week 24 (p≤0.012).
Croatian: Model logističke regresije prediktivne vrijednosti za genotip (prilagođen za početnu plazmatsku vrijednost HIV-1RNK [vRNK], broj CD4+ stanica, broj i trajanje prethodnih antiretrovirusnih terapija) pokazao je da je prisustvo 3 ili više mutacija povezanih s rezistencijom na NRTI povezano sa smanjenim odgovorom u 4. tjednu liječenja (p=0,015), a prisustvo 4 ili više mutacija prosječno u 24. tjednu (p≤0,012).
English: The pack also includes a polyethylene syringe-adapter and a 10 ml oral dosing syringe comprised of a polypropylene barrel (with ml graduations) and a polyethylene plunger.
Croatian: Pakiranje također sadrži polietilenski nastavak za štrcaljku, štrcaljku od 10 ml za oralno doziranje od polipropilenske cijevi (sa oznakama ml) i polietilenskim klipom.
English: Other medicines and Ziagen Tell your doctor or pharmacist if you are taking any other medicines, or if you have taken any recently, including herbal medicines or other medicines you bought without a prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzimali bilo koji drugi lijek uključujući biljne lijekove i lijekove koje ste kupili bez recepta.
English: Talk to your doctor before you start again.
Croatian: Obavijestite svog liječnika prije nego li ponovno započnete s terapijom.
English: The induction of drug metabolising enzymes cannot therefore be excluded.
Croatian: Stoga se ne može isključiti indukcija enzima koji metaboliziraju lijekove.
English: Turn bottle upside down
Croatian: Okrenite bocu naopako
English: Abacavir is metabolised intracellularly to the active moiety, carbovir 5'- triphosphate (TP).
Croatian: Abakavir se metabolizira unutar stanice u aktivni metabolit, karbovir 5'-trifosfat (TP).
English: Abacavir was not mutagenic in bacterial tests but showed activity in vitro in the human lymphocyte chromosome aberration assay, the mouse lymphoma assay, and the in vivo micronucleus test.
Croatian: Abakavir nije bio mutagen u testovima na bakterijama, ali je pokazao aktivnost in vitro u testovima kromosomske aberacije na humanim limfocitima, mišjem limfomu i mikronukleusnom testu in vivo.