FrancophonIA/ELRC3.0 huggingface dataset:
English: Adverse reactions are listed by system organ class and ranked by frequency in Table 1, reflecting data from the following sources: - Adverse reactions reported in osteoarthritis patients and rheumatoid arthritis patients at incidence rates greater than 0.01% and greater than those reported for placebo during 12 placebo- and/or active-controlled clinical trials of duration up to 12 weeks at celecoxib daily doses from 100 mg up to 800 mg.
Slovenian: - Neželeni učinki, opisani pri bolnikih z osteoartritisom in revmatoidnim artritisom z incidenco nad 0,01 % in večjo kot pri placebu v 12 s placebom in/ali učinkovino kontroliranih kliničnih preskušanjih, v katerih so do 12 tednov prejemali od 100 do 800 mg celekoksiba.
English: Blood levels increased: potassium, sodium, hemoglobin Blood levels decreased: hematocrit, testosterone
Slovenian: Zvišanje kalija, natrija, hemoglobina v krvi Znižanje hematokrita, testosterona v krvi
English: Renal function should be monitored when celecoxib and any of these medicinal products are combined.
Slovenian: Med kombinirano uporabo celekoksiba in katerega od teh zdravil je treba nadzirati delovanje
English: As the cardiovascular risks of celecoxib were increased with the 400 mg twice daily dose in the APC trial (section 5.1), the response of the FAP patient to celecoxib should be re-examined periodically in order to avoid unnecessary exposure in FAP patients for whom celecoxib is not effective (sections 4.2, 4.3, 4.8 and 5.1).
Slovenian: Zato je treba odziv bolnikov s FAP na celekoksib redno preverjati, da bi preprečili nepotrebno izpostavljanje zdravilu pri bolnikih s FAP, pri katerih celekoksib ni učinkovit (glejte poglavja 4.2, 4.3, 4.8 in 5.1).
English: No statistically significant inhibition of COX-1 (assessed as ex vivo inhibition of thromboxane B2 [TxB2] formation) was observed in healthy volunteers at the FAP therapeutic dose of 400 mg BID.
Slovenian: Pri zdravih prostovoljcih, ki so dobivali odmerek 400 mg dvakrat na dan, kot se terapevtsko uporablja pri FAP, niso opazili statistično značilnega zavrtja COX-1 (ocenjenega z zavrtjem nastajanja tromboksana B2 [TxB2] ex
English: Each capsule contains 400 mg celecoxib
Slovenian: Ena kapsula vsebuje 400 mg celekoksiba.
English: Safety data were reviewed in detail by a Data Safety Monitoring Committee, which concluded that celecoxib 16 mg/kg/day was a safe dose to recommend for further studies in juvenile
Slovenian: Ta je presodil, da je odmerek celekoksiba 16 mg/kg/dan mogoče varno priporočiti za nadaljnje študije bolnikov z juvenilno FAP.
English: The majority of the interaction studies have been performed with celecoxib doses of 200 mg BID (i.e. those used for osteoarthritis/rheumatoid arthritis).
Slovenian: Večina študij interakcij je bila opravljena s celekoksibom v odmerkih 200 mg dvakrat na dan (to je odmerkih, ki se uporabljajo pri osteoartritisu/revmatoidnem artritisu), zato ni mogoče izključiti, da ima odmerek 400 mg dvakrat na dan izrazitejše učinke.
English: In individuals who are CYP2C9 poor metabolisers and demonstrate increased systemic exposure to celecoxib, concomitant treatment with CYP2C9 inhibitors (eg.
Slovenian: Pri posameznikih, ki slabo presnavljajo s CYP2C9 in imajo večjo sistemsko izpostavljenost celekoksibu, lahko sočasno zdravljenje z zaviralci CYP2C9 (npr. flukomazol, amiodaron) dodatno poveča izpostavljenost celekoksibu.
English: 6.6 Special precautions for disposal and other handling
Slovenian: 6.6 Navodila za pripravo in ravnanje z zdravilom
English: In final data (adjudicated) from the APC trial in patients treated with celecoxib 800 mg daily for up to 3 years, the excess rates over placebo were 11 events per 1000 patients for myocardial infarction (common); and 5 events per 1000 patients for stroke (uncommon; types of stroke not differentiated).
Slovenian: Po oceni končnih podatkov preskušanj APC in PreSAP pri bolnikih, zdravljenih z 800 mg celekoksiba na dan do 3 leta, je bil presežni delež miokardnih infarktov v primerjavi s placebom 11 dogodkov na 1000 bolnikov (pogosto) in možganskih kapi 5 dogodkov na 1000 bolnikov (občasno; kapi
English: If you have heart problems such as pain in the chest If you have liver failure (symptoms may include nausea (feeling sick), diarrhoea, jaundice (your skin or the whites of your eyes look yellow)
Slovenian: - če imate težave s srcem, npr. bolečine v prsih - če imate odpoved jeter (med simptomi so lahko navzea (slabost v želodcu), driska, zlatenica
English: Very Common side-effects (affecting more than 1 person in every 10):
Slovenian: Zelo pogosti neželeni učinki (pojavijo se pri več kot 1 od 10 bolnikov): - visok krvni tlak*, driska*
English: Pfizer ApS Tlf: +45 44 20 11 00
Slovenian: Tlf: +45 44 20 11 00
English: Symptoms may include sudden breathlessness, sharp pains when you breathe or collapse
Slovenian: Znaki lahko vključujejo nanadno zadihanost, ostre bolečine pri dihanju ali nagel padec krvnega tlaka, zaradi katerega se lahko nenadoma zgrudite
English: − if you are being treated for an infection, because Onsenal may mask a fever which is a sign of
Slovenian: - če imate intoleranco za nekatere sladkorje - če se zdravite zaradi okužbe, kajti zdravilo Onsenal lahko prikrije zvišano telesno temperaturo,
English: • Patients who have experienced asthma, acute rhinitis, nasal polyps, angioneurotic oedema,
Slovenian: (ciklooksigenaze-2), kdaj imeli astmo, akutni rinitis, nosne polipe, angionevrotični edem,
English: Compared to subjects with normal hepatic function, patients with mild hepatic impairment had a mean increase in Cmax of 53% and in AUC of 26% of celecoxib.
Slovenian: Pri bolnikih z blago jetrno okvaro je bila Cmax celekoksiba v povprečju za 53 % večja, AUC pa za 26 % večja kot pri preiskovancih z normalnim delovanjem jeter.
English: Serious allergic reactions, anaphylactic shock, anaphylaxis
Slovenian: levkopenija, trombocitopenija pancitopenija resne alergijske reakcije, anafilaktični šok, anafilaksija zmedenost halucinacije
English: - Acetylsalcylic acid or other anti-inflammatory medicines - Cyclosporin and tacrolimus (used for immune system suppression e.g. after transplants) - Dextromethorphan (used as an antitussive in cough mixtures) - Diuretics (used to treat fluid retention) - Fluconazole (used to treat fungal infections)
Slovenian: - zaviralce ACE ali antagoniste receptorjev angiotenzina II (uporabljajo se za zdravljenje visokega krvnega tlaka in srčnega popuščanja) - acetilsalicilno kislino ali druga protivnetna zdravila - ciklosporin ali takrolimus (uporabljata se za zaviranje imunskega sistema, npr. po presaditvah) - dekstrometorfan (uporablja se kot sredstvo proti kašlju v kombinacijah proti kašlju) - diuretike (uporabljajo se za zdravljenje zastajanja tekočine) - flukonazol (uporablja se za zdravljenje glivičnih okužb) - litij (uporablja se za zdravljenje depresije) - rifampicin (uporablja se za zdravljenje bakterijskih okužb) - varfarin (uporablja se za preprečevanje strjevanja krvi) ali druge antikoagulante - druga zdravila proti depresiji, nespečnosti, visokemu krvnemu tlaku ali nerednemu srčnemu
English: - if you have severe kidney disease - if you have heart failure, established heart disease and /or cerebrovascular disease, e.g. if you have had a heart attack, stroke, mini-stroke (TIA) or blockages of blood vessels to the heart or brain - if you have had an operation to clear or bypass blockages
Slovenian: - če imate vnetje kolona (ulcerozni kolitis) ali črevesja (Crohnovo bolezen) - če imate hudo bolezen jeter - če imate hudo bolezen ledvic - če imate srčno popuščanje, potrjeno srčno bolezen ali cerebrovaskularno bolezen ali oboje, npr. ste imeli srčni infarkt, kap, lažjo obliko kapi (tranzitorna ishemična ataka - TIA), ali zamašitev krvnih žil srca ali možganov, ali operativno odstranitev ali obvod zamašenega dela, ali če imate oz. ste imeli težave s krvnim obtokom (bolezen perifernih arterij) ali operacijo na arterijah nog
English: In the APC trial, there was a dose-related increase in the composite endpoint of cardiovascular death, myocardial infarction, or stroke (adjudicated) with celecoxib compared to placebo over 3 years of treatment.
Slovenian: V preskušanju APC so med 3-letnim zdravljenjem pri celekoksibu v primerjavi s placebom ugotovili z odmerkom povezan porast sestavljenega opazovanega dogodka srčnožilne smrti, miokardnega infarkta ali možganske kapi (presojeno).
English: The capsules are white with ‘7767‘ and ‘200‘ marked in gold ink.
Slovenian: Kapsule so bele in na njih je z zlatim črnilom napisano "7767" in "200".
English: − if you are over 65 years of age your doctor may want to keep a regular check on you As with other non-steroidal, anti-inflammatory drugs (NSAIDs; eg, ibuprofen or diclofenac), this medicine may lead to an increase in blood pressure, and so your doctor may ask to monitor your blood
Slovenian: Tako kot druga nesteroidna protivnetna zdravila (npr. ibuprofen ali diklofenak) lahko tudi do zdravilo povzroči zvišanje krvnega tlaka, zato vam bo zdravnik morda naročil, da morate redno kontrolirati
English: CYP2C9 Poor Metabolizers: Patients who are known or suspected to be CYP2C9 poor metabolizers based on genotyping or previous history/experience with other CYP2C9 substrates should be administered celecoxib with caution, as the risk of dose-dependent adverse effects is increased.
Slovenian: Bolniki, ki slabo presnavljajo s CYP2C9: Celekoksib morate previdno uporabljati pri bolnikih, za katere na podlagi anamneze ali izkušenj z drugimi substrati CYP2C9 veste ali sumite, da slabo presnavljajo s CYP2C9.
English: The capsules are white with ‘7767‘ and ‘400‘ marked in green ink.
Slovenian: Kapsule so bele in na njih je z zlatim črnilom napisano "7767" in "400".
English: The relative risk compared to placebo for a similar composite endpoint (CV death, MI, stroke) was 1.14 (95% CI 0.61 - 2.12) with celecoxib 200 mg twice daily.
Slovenian: Relativno tveganje za podoben sestavljeni opazovani dogodek (srčnožilna smrt, miokardni infarkt, možganska kap) je bilo za celekoksib 200 mg dvakrat na dan v primerjavi s placebom 1,14 (95 % IZ: 0,61-2,12).
English: − High levels of sodium or haemoglobin and low levels of hematocrit or testosterone in blood test
Slovenian: - velika koncentracija natrija ali hemoglobina in majhna koncentracija hematokrita ali
English: croscarmellose sodium, magnesium stearate and the colouring agent titanium dioxide E171.
Slovenian: - Pomožne snovi so želatina, laktoza monohidrat, natrijev lavrilsulfat, povidon K30, premreženi natrijev karmelozat, magnezijev stearat in barvilo titanov dioksid E171.
English: A significant difference in GI safety between selective COX-2 inhibitors + acetylsalicylic acid vs. NSAIDs + acetylsalicylic acid has not been demonstrated in long-term clinical trials (see 5.1).The concomitant use of celecoxib and a non-aspirin NSAID should be avoided.
Slovenian: Glede varnosti za prebavila v dolgoročnih kliničnih preskušanjih niso ugotovili pomembne razlike med uporabo selektivnih zaviralcev COX-2 in acetilsalicilne kisline v primerjavi z uporabo nesteroidnih protivnetnih zdravil in acetilsalicilne kisline (glejte poglavje 5.1).
English: urticaria or other allergic-type reactions after taking acetylsalicylic acid or non steroidal anti inflammatory drugs (NSAIDs) including COX-2 (cyclooxigenase-2) selective inhibitors.
Slovenian: „non steroidal antiinflammatory drugs“), vključno s selektivnimi zaviralci COX-2
English: Confusion
Slovenian: Drugo
English: − Skin discolouration (bruising), muscle pain and weakness, painful joints
Slovenian: (slabost v želodcu), mišične krče in šibkost)
English: Patients who are known or suspected to be CYP2C9 poor metabolizers based on previous history/experience with other CYP2C9 substrates should be administered celecoxib with caution (see Section 4.2).
Slovenian: Celekoksib morate previdno uporabljati pri bolnikih, za katere na podlagi anamneze ali izkušenj z drugimi substrati CYP2C9 veste ali sumite, da slabo presnavljajo s CYP2C9 (glejte poglavje 4.2).
English: Excipients: Lactose Monohydrate 99.6 mg For a full list of excipients, see section 6.1.
Slovenian: Pomožne snovi: laktoza monohidrat 99,6 mg.
English: − if you have heart failure, established heart disease and /or cerebrovascular disease, e.g. if you have had a heart attack, stroke, mini-stroke (TIA) or blockages of blood vessels to the heart or brain
Slovenian: - če imate srčno popuščanje, potrjeno srčno bolezen ali cerebrovaskularno bolezen ali oboje, npr. ste imeli srčni infarkt, kap, lažjo obliko kapi (tranzitorna ishemična ataka - TIA), ali zamašitev krvnih žil, srca ali možganov, ali operativno odstranitev ali obvod zamašenega dela, ali če imate oz. ste imeli težave s krvnim obtokom (bolezen perifernih arterij) ali operacijo na arterijah nog
English: Always take Onsenal exactly as your doctor has told you.
Slovenian: Pri jemanju zdravila Onsenal natančno upoštevajte zdravnikova navodila.
English: Ganglion
Slovenian: PSUR
English: In the PreSAP trial, the relative risk compared to placebo for this same composite endpoint (adjudicated) was 1.2 (95% CI 0.6 - 2.4) with celecoxib 400 mg once daily compared to placebo.
Slovenian: V preskušanju PreSAP je bilo relativno tveganje za isti sestavljeni opazovani dogodek (presojeno) pri celekoksibu 400 mg enkrat na dan v primerjavi s placebom 1,2 (95 % IZ: 0,6-2,4).
English: Common side effects which may affect more than 1 person in 100, are listed below
Slovenian: Pogosti neželeni učinki, ki se lahko pojavijo pri več kot 1 od 100 oseb, so: - kopičenje tekočine v telesu, ki lahko povzroči oteklost gležnjev in nog
English: NAME OF THE MEDICINAL PRODUCT Onsenal 200 mg hard capsules
Slovenian: Onsenal 200 mg trde kapsule
English: As with other medicinal products known to inhibit prostaglandin synthesis, fluid retention and oedema have been observed in patients taking celecoxib.
Slovenian: Pri bolnikih, ki so jemali celekoksib, so zabeležili zastoj tekočine in edeme, tako kot pri drugih zdravilih, ki zavirajo sintezo prostaglandinov.
English: In a two-year toxicity study an increase in nonadrenal thrombosis was observed in male rat at high
Slovenian: V dveletni študiji toksičnosti so pri podganjih samcih ob velikih odmerkih opažali več neadrenalne povidon K30 premreženi natrijev karmelozat magnezijev stearat
English: A dose-dependent effect on TxB2 formation has been observed after high doses of celecoxib.
Slovenian: Po velikih odmerkih celekoksiba so opažali od odmerka odvisen učinek na nastajanje TxB2.
English: − Sinusitis (sinus inflammation, sinus infection, blocked or painful sinuses), blocked or runny nose, sore throat, coughs, colds, flu-like symptoms
Slovenian: - sinuzitis (vnetje obnosnih votlin, okužba obnosnih votlin, zamašene ali boleče obnosne votline), zamašen nos ali izcedek iz nosu, vnetje žrela, okužbe v prsnem košu, kašelj, prehlad, gripi
English: Edema site conditions Investigations
Slovenian: Splošne težave in spremembe na mestu aplikacije edemi
English: Onsenal 400 mg hard capsules celecoxib
Slovenian: Onsenal 400 mg trde kapsule celekoksib
English: Onsenal 200 mg hard capsules celecoxib
Slovenian: Onsenal 200 mg trde kapsule celekoksib
English: You will usually take one 400 mg
Slovenian: Ponavadi boste jemali po eno 400-mg kapsulo dvakrat na dan.
English: − Impaired or blurred vision, ringing in the ears, mouth pain and soresConstipation, burping, stomach inflammation (indigestion, stomach ache or vomiting), worsening of inflammation of
Slovenian: utrujenost, šibkost mišic ali palpitacije) - poslabšan ali zamegljen vid, zvonjenje v ušesih, bolečine in razjede v ustih - zaprtje, spahovanje, vnetje želodca (težave z želodcem, bolečine v želodcu ali bruhanje),
English: Elevation of hepatic enzymes
Slovenian: Preiskave povečanje telesne mase
English: diabetes, high cholesterol or if you smoke you should discuss with your doctor whether Onsenal is suitable for you - if you have had a stomach or duodenal (intestinal) ulcer or bleeding in the stomach or intestines - if your heart, liver, or kidneys are not working well, your doctor may want to keep a regular
Slovenian: Onsenal za vas primeren - če ste imeli razjedo na želodcu ali dvanajstniku (črevesu) ali krvavitev v želodec ali črevo - če srce, jetra ali ledvice ne delujejo dobro, vas bo zdravnik morda redno kontroliral - če vam v telesu zastaja tekočina (imate npr. otekle gležnje ali stopala) - če ste izsušeni (dehidrirani), npr. zaradi bruhanja ali driske, ali če jemljete diuretike (zdravila za
English: Experience with celecoxib in patients with mild or moderate renal or hepatic impairment is limited, therefore such patients should be treated with caution (see sections 4.2 and 5.2).
Slovenian: Izkušenj s celekoksibom pri bolnikih z blago ali zmerno ledvično ali jetrno okvaro je malo, zato je takšne bolnike treba zdraviti previdno.
English: Paediatric patients: Experience with celecoxib in FAP patients below the age of 18 years is limited to a single pilot study in a very small population, in which patients were treated with celecoxib at doses up to 16 mg/kg daily, which corresponds to the recommended adult FAP dose of 800 mg daily (see
Slovenian: Otroci: Izkušnje s celekoksibom pri bolnikih s FAP, mlajših od 18 let, so omejene na eno samo pilotsko študijo v zelo majhni populaciji.
English: Upper gastrointestinal complications [perforations, ulcers or bleeds (PUBs)], some of them resulting in fatal outcome, have occurred in patients treated with celecoxib.
Slovenian: Pri bolnikih, zdravljenih s celekoksibom, so se pojavljali zapleti na zgornjih prebavilih [perforacije, ulkusi in krvavitve], ki so bili v nekaterih primerih smrtni.
English: Headache, aggravated epilepsy, meningitis aseptic, ageusia , anosmia, fatal intracranial haemorrhage Conjunctivitis, ocular haemorrhage, retinal artery or vein occlusion
Slovenian: Bolezni živčevja omotica, hipertonija parestezije, somnolenca ataksija, spremembe okusa glavobol, poslabšanje epilepsije, aseptični meningitis, agevzija, anozmija, intrakranialna krvavitev s smrtnim izidom
English: − If you have severe stomach pain or any sign of bleeding in the stomach or intestines, such as passing black or bloodstained bowel movements, or vomiting blood
Slovenian: (porumenelost kože in očesnih beločnic)) - če se vam na koži pojavijo mehurji ali se koža lupi - če imate hude bolečine v želodcu ali kakšen znak krvavitve v želodcu ali črevesu, npr. črno ali
English: Make sure that your doctor knows before you start taking Onsenal:
Slovenian: Preden začnete jemati zdravilo Onsenal, poskrbite, da bo zdravnik
English: Common side effects which may affect more than 1 person in 100, are listed below - Fluid build up with swollen ankles, legs and/or hands - Urinary infections - Sinusitis (sinus inflammation, sinus infection, blocked or painful sinuses), blocked or runny nose, sore throat, coughs, colds, flu-like symptoms - Dizziness, difficulty sleeping - stomach ache, diarrhoea, indigestion, wind - Rash, itching
Slovenian: Občasni neželeni učinki, ki se lahko pojavijo pri več kot 1 od 1.000 oseb, so: - srčno popuščanje, palpitacije (zavedanje bitja srca), hitro bitje srca - poslabšanje že zvišanega krvnega tlaka - nepravilnosti krvnih preiskav, ki kažejo delovanje jeter - nepravilnosti krvnih preiskav, ki kažejo delovanje ledvic - anemija (spremembe rdečih krvnih celic, ki lahko povzročijo utrujenost in težko dihanje) - anksioznost (tesnoba), depresija, utrujenost, zaspanost , mravljinčenje - visoka koncentracija kalija pri preiskavi krvi (lahko povzroči navzeo (slabost v želodcu),
English: Medicinal product subject to medical prescription.
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe.
English: − Ulcers (bleeding) in the stomach, gullet or intestines; or rupture of the intestine (can cause stomach ache, fever, nausea, vomiting, intestinal blockage), dark or black stools, inflammation of the gullet (can cause difficulty in swallowing), inflammation of the pancreas (can lead to
Slovenian: Simptomi so lahko siljenje na bruhanje, driska, zlatenica), vnetje jeter (povzroči lahko rumeno obarvanje kože ali očesnih beločnic, temen urin, svetlo blato, nagnjenost h krvavitvam, srbenje ali mrzlica) - težave z ledvicami (možnost odpovedi ledvic, vnetje ledvic) - krvni strdek v pljučnih žilah.
English: NAME OF THE MEDICINAL PRODUCT Onsenal 400 mg hard capsules
Slovenian: Onsenal 400 mg trde kapsule
English: Excipients: Lactose Monohydrate 49.8 mg For a full list of excipients, see section 6.1.
Slovenian: Pomožne snovi: laktoza monohidrat 49,8 mg.
English: COX-2
Slovenian: 2 aritmija
English: Vaginal haemorrhage, breast tenderness, dysmenorrhea, ovarian cyst, menopausal symptoms
Slovenian: Motnje reprodukcije in dojk benigna hipertrofija prostate, prostatitis, zvišanje za prostato specifičnega antigena krvavitev iz nožnice, občutljivost dojk, dismenoreja, cista jajčnika, menopavzalni simptomi
English: Ecchymosis, bullous eruption, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema Arthralgia, myositis
Slovenian: zardevanje, vaskulitis, pljučna embolija bronhospazem razjeda na dvanajstniku, želodcu, požiralniku, tankem in debelem črevesu, disfagija, perforacija črevesa, ezofagitis, melena, pankreatitis navzea, akutni pankreatitis, gastrointestinalna krvavitev, kolitis/poslabšanje kolitisa zvišanje jetrnih encimov hepatitis, jetrna odpoved, zlatenica alopecija, fotosenzitivnost ekhimoze, bulozen izpuščaj, eksfoliativni dermatitis, multiformni eritem, Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, angioedem artralgija, miozitis akutna odpoved ledvic, intersticijski nefritis, hiponatriemija reprodukcije in dojk menstruacijske motnje
English: − If you have liver failure (symptoms may include nausea (feeling sick), diarrhoea, jaundice (your skin or the whites of your eyes look yellow))
Slovenian: - če imate odpoved jeter (med simptomi so lahko navzea (slabost v želodcu), driska, zlatenica
English: − Stomach problems: nausea, heartburn, diverticulum (a problem with the stomach or intestine that can become painful or infected), vomiting*, irritable bowel syndrome (can include stomach
Slovenian: - težave s srcem: srčni infarkt,* angina pektoris (bolečine v prsih) - težave z želodcem: siljenje na bruhanje, zgaga, divertikel (težava z želodcem ali črevesom, ki lahko boli ali se okuži), bruhanje,* sindrom razdražljivega črevesa (lahko obsega bolečine v trebuhu, drisko, prebavne težave, vetrove) - ledvični kamni (ki lahko povzročijo bolečine v trebuhu ali hrbtu, kri v urinu), težave pri odvajanju urina, zvišan kreatinin (preiskava krvi, povezana z delovanjem ledvic
English: − A reduction in the number of red and white blood cells and platelets (may cause tiredness, easy bruising, frequent nose bleeds and increased risk of infections)
Slovenian: okužbo očesa (pordelo oko), krvavitev v očesu - zmanjšanje števila belih in rdečih krvnih celic in krvnih ploščic (povzroči utrujenost, poveča verjetnost podplutb, pogostejše krvavitve iz nosu in poveča verjetnost okužb - bolečina v prsnem košu - okvarjen voh - obarvanje kože (podplutbe), bolečine v mišicah in šibkost mišic, boleči sklepi
English: COX-2 is the isoform of the enzyme that has been shown to be induced by proinflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation and fever.
Slovenian: COX-2 izooblike ni najti v večini normalnih tkiv in je pod nadzorom inducibilnega promotorja, njegova izraženost pa je povezana z vnetjem.
English: Bronchospasm
Slovenian: pri placebu.
English: (12/628 subjects), respectively.
Slovenian: (glejte poglavji 4.2 in 5.2).
English: NAME OF THE MEDICINAL PRODUCT Onsenal 200 mg capsules Celecoxib
Slovenian: Onsenal 200 mg kapsule celekoksib
English: − Serious allergic reactions (including potentially fatal anaphylactic shock) which can cause skin rash, swelling of the face, lips, mouth, tongue or throat, wheezing or difficulty breathing;
Slovenian: Pogostnosti teh učinkov je težko ugotoviti, a praviloma veljajo za zelo redke (pojavijo se pri manj kot 1 od 10.000 bolnikov) - krvavitev v možgane, ki povzroči smrt - resne alergijske reakcije (vključno z anafilaktičnim šokom, lahko s smrtnim izidom), ki lahko povzročijo izpuščaj na koži, otekanje obraza, ustnic, ust, jezika ali žrela, piskajoče dihanje ali