FrancophonIA/ELRC3.0 huggingface dataset:
English: Take your other HIV medicines used in combination with Darunavir Krka d.d.
Danish: - Tag din anden hiv-medicin, der skal bruges sammen med Darunavir Krka d.d.
English: Outcomes darunavir/ritonavir
Danish: Darunavir/ritonavir
English: together with 150 milligram cobicistat or 100 milligram ritonavir once daily.
Danish: sammen med 150 mg cobicistat eller 100 mg ritonavir en gang dagligt.
English: might increase the risk for elevated potassium levels by drospirenone.
Danish: kan muligvis øge risikoen for forhøjet kaliumindhold i blodet pga. drospirenon.
English: Based on normal approximation to the difference in % response Non-completer is failure imputation: patients who discontinued prematurely are imputed with a change equal to 0
Danish: I henhold til TLOVR-algoritmen (time to loss of viral response) Baseret på en normal approksimation af forskellen i % respons Patienter, der ikke fuldførte behandlingen, betragtes som havende behandlingssvigt, dvs. patienter der afbrød behandlingen i utide medregnes med en ændring, der tillægges størrelsen 0.
English: Always take with cobicistat or ritonavir and food.
Danish: med cobicistat eller ritonavir og mad.
English: Dose for children 3 years of age and above, weighing more than 40 kilograms who have taken antiretroviral medicines before (your child's doctor will determine this) The dose is either: 800 milligram Darunavir Krka d.d.
Danish: Dosis til børn fra 3 år og opefter med en legemsvægt på mindst 40 kg, som tidligere har fået medicin mod hiv-infektion (barnets læge vil afgøre dette) Dosis er enten: - 800 mg Darunavir Krka d.d.
English: Co-administration of boosted darunavir with clonazepam may increase concentrations of clonazepam.
Danish: Co-administration af boostet darunavir med clonazepam kan øge koncentrationen af clonazepam.
English: For additional clinical study results in ART-experienced adults and paediatric patients, refer to the Summary of Product Characteristics for Darunavir Krka d.d.
Danish: Vedrørende yderligere kliniske studieresultater hos ART-erfarne voksne og pædiatriske patienter henvises til produktresumeet for Darunavir Krka d.d.
English: - The other ingredients are cellulose, microcrystalline; crospovidone, hydroxypropylcellulose; silica, colloidal anhydrous; silicified microcrystalline cellulose (cellulose, microcrystalline; silica, colloidal anhydrous) and magnesium stearate (E470b) in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) and red iron oxide (E172) in film coating.
Danish: - Øvrige indholdsstoffer: mikrokrystallinsk cellulose, crospovidon, hydroxypropylcellulose, silica, kolloid vandfri, silicificeret mikrokrystallinsk cellulose (mikrokrystallinsk cellulose; silica, kolloid vandfri) og magnesiumstearat (E470b) i tabletkernen og polyvinylalkohol, macrogol, titandioxid (E171), talcum (E553b), jernoxid, gul (E172) og jernoxid, rød (E172) i filmovertrækket.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu.
Danish: Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmesidehttp://www.ema.europa.eu.
English: ANTIMALARIALS Artemether/Lumefantrine 80/480 mg, 6 doses at 0, 8, 24, 36, 48, and 60 hours artemether AUC ↓ 16% artemether Cmin ↔ artemether Cmax ↓ 18% dihydroartemisinin AUC ↓ 18% dihydroartemisinin Cmin ↔ dihydroartemisinin Cmax ↓ 18% lumefantrine AUC ↑ 175% lumefantrine Cmin ↑ 126% lumefantrine Cmax ↑ 65% darunavir AUC ↔ darunavir Cmin ↓ 13% darunavir Cmax ↔
Danish: MALARIAMIDLER Artemether/lumefantrin 80/480 mg, 6 doser efter 0,8, 24, 36, 48 og 60 timer artemether AUC ↓ 16% artemether Cmin ↔ artemether Cmax ↓ 18% dihydroartemisinin AUC ↓ 18% dihydroartemisinin Cmin ↔ dihydroartemisinin Cmax ↓ 18% lumefantrin AUC ↑ 175% lumefantrin Cmin ↑ 126% lumefantrin Cmax ↑ 65% darunavir AUC ↔ darunavir Cmin ↓ 13% darunavir Cmax ↔
English: A dose decrease may be needed for these drugs when co-administered with boosted darunavir.
Danish: Det kan være nødvendigt at nedsætte dosis af disse lægemidler ved co-administration med boostet darunavir.
English: Co-administration of boosted darunavir with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Danish: Co-administration af boostet darunavir med disse antikoagulantia kan øge koncentrationerne af antikoagulanset hvilket kan medføre en øget blødningsrisiko.
English: and raltegravir (for HIV infection), rashes (generally mild or moderate) may occur more frequently than in patients taking either medicine separately.
Danish: sammen med raltegravir (mod hiv-infektion), kan hyppigere få udslæt end patienter, der kun får det ene af disse lægemidler.
English: effects.
Danish: Bivirkning
English: Alternative or additional contraceptive measures are recommended when oestrogen-based contraceptives are co-administered with boosted darunavir.
Danish: Det anbefales at bruge andre eller supplerende svangerskabsforebyggende metoder, når østrogenbaserede kontraceptiva gives sammen med boostet darunavir.
English: 400 and 800 milligram tablets are used to treat adults and children (3 years of age and above, at least 40 kilograms body weight) who are infected by HIV and who have not used antiretroviral medicines before.
Danish: 400 mg og 800 mg tabletter anvendes til at behandle voksne og børn (fra 3 år og opefter med en legemsvægt på mindst 40 kg), som er smittet med hiv, og - som ikke før har fået medicin til behandling af hiv - hos nogle patienter, som før har fået medicin til behandling af hiv (din læge vil afgøre dette).
English: ODIN is a Phase III, randomised, open-label trial comparing darunavir/ritonavir 800/100 mg once daily versus darunavir/ritonavir 600/100 mg twice daily in ART-experienced HIV-1 infected patients with screening genotype resistance testing showing no darunavir RAMs (i.e. V11I, V32I, L33F, I47V, I50V, I54M, I54L, T74P, L76V, I84V, L89V) and a screening HIV-1 RNA > 1,000 copies/ml.
Danish: ODIN er et randomiseret, åbent fase III-studie, der sammenligner darunavir/ritonavir 800/100 mg en gang dagligt med darunavir/ritonavir 600/100 mg to gange dagligt hos ART-erfarne hiv-1-inficerede patienter, hos hvem screening for genotype-resistens har vist, at der ikke fandtes darunavir RAMs (dvs. V11I, V32I, L33F, I47V, I50V, I54M, I54L, T74P, L76V, I84V, L89V), og screening for hiv-1- RNA viste > 1.000 kopier/ml.
English: HIV ANTIRETROVIRALS Integrase strand transfer inhibitors Dolutegravir dolutegravir AUC ↓ 22% dolutegravir C24h ↓38% dolutegravir Cmax ↓ 11% darunavir ↔* * Using cross-study comparisons to historical pharmacokinetic data
Danish: Dolutegravir dolutegravir AUC ↓ 22% dolutegravir C24t ↓ 38% dolutegravir Cmax ↓ 11% darunavir ↔* * Ved brug af historiske farmakokinetiske data på tværs af studier
English: ART-experienced paediatric patients (3 to 17 years of age and weighing at least 40 kg) In ART-experienced patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: ART-erfarne pædiatriske patienter (3 til 17 år og legemsvægt mindst 40 kg) Hos ART-erfarne patienter, der ikke har DRV-RAMs*, og som har plasma-hiv-1RNA < 100.000 kopier/ml og CD4+-celletal ≥ 100 x 10
English: If antidepressants are co-administered with boosted darunavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Danish: Hvis antidepressiva coadministreres med boostet darunavir, anbefales dosistitrering af det antidepressive lægemiddel ud fra en klinisk vurdering af antidepressivt respons.
English: Buprenorphine/naloxone 8/2 mg-16/4 mg once daily buprenorphine AUC ↓ 11% buprenorphine Cmin ↔ buprenorphine Cmax ↓ 8% norbuprenorphine AUC ↑ 46% norbuprenorphine Cmin ↑ 71% norbuprenorphine Cmax ↑ 36% naloxone AUC ↔ naloxone Cmin ND naloxone Cmax ↔
Danish: Buprenorphin/naloxon 8/2 mg-16/4 mg en gang daglig buprenorphin AUC ↓ 11% buprenorphin Cmin ↔ buprenorphin Cmax ↓ 8% norbuprenorphin AUC ↑ 46% norbuprenorphin Cmin ↑ 71% norbuprenorphin Cmax ↑ 36% naloxon AUC ↔ naloxon Cmin ND naloxon Cmax ↔
English: 400 mg and 800 mg tablets can be used to construct the once daily 800 mg regimen.
Danish: 400 mg og 800 mg tabletter kan anvendes til at sammensætte regimet med 800 mg en gang dagligt.
English: Clinical monitoring is recommended when co-administering darunavir with low dose ritonavir with these antidepressants and a dose adjustment of the antidepressant may be needed.
Danish: Klinisk monitorering anbefales ved co-administration af darunavir med lavdosis ritonavir og disse antidepressiva, og det kan være nødvendigt at justere dosis af antidepressivummet.
English: is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka d.d.
Danish: er 800 mg (2 tabletter a 400 mg Darunavir Krka d.d.
English: Co-administration of darunavir coadministered with cobicistat and rifabutin is not recommended.
Danish: Co-administration af darunavir coadministreret med cobicistat og rifabutin frarådes.
English: The metabolism of alfentanil is mediated via CYP3A, and may as such be inhibited by darunavir co-administered with low dose ritonavir.
Danish: Alfentanil metabolisees via CYP3A og kan dermed hæmmes af darunavir administreret sammen med lavdosis ritonavir.
English: ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17% 14-OH-clarithromycin concentrations were not detectable when combined with darunavir/ritonavir.
Danish: ANTIBIOTIKA Clarithromycin 500 mg to gange daglig clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% #darunavir AUC ↓ 13% #darunavir Cmin ↑ 1% #darunavir Cmax ↓ 17% 14-OH-clathromycinkoncentrationenerne var ikke målbare ved kombination med darunavir/ritonavir.
English: Nevirapine 200 mg twice daily nevirapine AUC ↑ 27% nevirapine Cmin ↑ 47% nevirapine Cmax ↑ 18% darunavir: concentrations were consistent with historical data (↑ nevirapine from CYP3A inhibition)
Danish: Nevirapin 200 mg to gange daglig nevirapin AUC ↑ 27% nevirapin Cmin ↑ 47% nevirapin Cmax ↑ 18% #darunavir: koncentrationerne var i overensstemmelse med historiske data.
English: Corticosteroids including bethametasone, budesonide, fluticasone, mometasone, prednisone, triamcinolone.
Danish: - Kortikosteroider, herunder betamehtason, budesonid, fluticason, mometason, prednison, triamcinolon.
English: Lovastatin and simvastatin are expected to have markedly increased plasma concentrations when coadministered with darunavir coadministered with low dose ritonavir.
Danish: Plasmakoncentrationen af lovastatin og simvastatin forventes at stige markant, når de gives sammen med darunavir co-administreret med lavdosis ritonavir.
English: TLOVR non-VF censored algorithm based on HIV-1 RNA < 50 copies/ml, except for TITAN (HIV-1 RNA < 400 copies/ml)
Danish: TLOVR non-VF censureret algoritme baseret på hiv-1-RNA <50 kopier/ml med undtagelse af TITAN (hiv-1RNA <400 kopier/ml) IAS-USA-lister
English: Co-administration of darunavir and ritonavir and other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (e.g. indinavir azole antifungals like clotrimazole).
Danish: Co-administration af darunavir og ritonavir med andre lægemidler, som hæmmer CYP3A, kan nedsætte clearance af darunavir og ritonavir, hvilket kan medføre øgede plasmakoncentrationer af darunavir og ritonavir (f.eks. indinavir, azolantimykotika som clotrimazol).
English: With Baseline CD4+ cell count (x 10
Danish: Med CD4+celletal (×10
English: 600 milligram Darunavir Krka d.d.
Danish: 600 mg Darunavir Krka d.d.
English: What you need to know before you take Darunavir Krka d.d.
Danish: Det skal du vide, før du begynder at tage Darunavir Krka d.d.
English: 600 mg once daily efavirenz AUC ↑ 21% efavirenz Cmin ↑ 17% efavirenz Cmax ↑ 15% darunavir AUC ↓ 13% darunavir Cmin ↓ 31% darunavir Cmax ↓ 15% (↑ efavirenz from CYP3A inhibition) (↓ darunavir from CYP3A induction)
Danish: 600 mg en gang daglig efavirenz AUC ↑ 21% efavirenz Cmin ↑ 17% efavirenz Cmax ↑ 15% #darunavir AUC ↓ 13% #darunavir Cmin ↓ 31% #darunavir Cmax ↓ 15% (↑ efavirenz fra CYP3A-hæmning) (↓ darunavir fra CYP3A-induktion)
English: Clinical monitoring is recommended when co-administering darunavir with low dose ritonavir and clonazepam.
Danish: Klinisk monitorering anbefales, når boostet darunavir administreres sammen med lavdosis ritonavir og clonazepam.
English: If you forget to take Darunavir Krka d.d.
Danish: Hvis du har glemt at tage Darunavir Krka d.d.
English: Fesoterodine, solifenacin(to treat urologic disorders).
Danish: - fesoterodin, solifenacin(til behandling af sygdomme i urinvejene).
English: Fesoterodine, solifenacin (to treat urologic disorders).
Danish: - Fesoterodin, solifenacin (til behandling af sygdomme i urinvejene).
English: With baseline HIV-RNA ≥
Danish: Med hiv-RNA <100.000 ved baseline Med hiv-RNA
English: Dose for children 3 years of age and above, weighing more than 40 kilograms who have not taken antiretroviral medicines before (your child's doctor will determine this) The usual dose of Darunavir Krka d.d.
Danish: Dosis til børn fra 3 år og opefter med en legemsvægt på mindst 40 kg, som ikke tidligere har fået medicin mod hiv-infektion (barnets læge vil afgøre dette) - Den sædvanlige dosis af Darunavir Krka d.d.
English: ≥ 30 kg-< 40 kg 675 mg darunavir/100 mg ritonavir once daily
Danish: ≥30 kg-<40 kg 675 mg darunavir/100 mg ritonavir en gang dagligt
English: OR
Danish: eller
English: that the lowest possible dose of digoxin should initially be prescribed in case digoxin is given to patients on darunavir/ritonavir therapy.
Danish: Da digoxin har et snævert terapeutisk indeks, anbefales det at starte med at udskrive den lavest mulige dosis digoxin, hvis der skal gives digoxin til patienter i behandling med darunavir/ritonavir.
English: Lopinavir/ritonavir 533/133.3 mg twice daily lopinavir AUC ↑ 9% lopinavir Cmin ↑ 23% lopinavir Cmax ↓ 2% darunavir AUC ↓ 38% darunavir Cmin ↓ 51% darunavir Cmax ↓ 21% lopinavir AUC ↔ lopinavir Cmin ↑ 13% lopinavir Cmax ↑ 11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% based upon non dose normalised values
Danish: Lopinavir/ritonavir 533/133,3 mg to gange daglig lopinavir AUC ↑ 9% lopinavir Cmin ↑ 23% lopinavir Cmax ↓ 2% darunavir AUC ↓ 38%‡ darunavir Cmin ↓ 51%‡ darunavir Cmax ↓ 21%‡ lopinavir AUC ↔ lopinavir Cmin ↑ 13% lopinavir Cmax ↑ 11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% ‡ baseret på ikkedosisnormaliserede værdier
English: section 4.3).
Danish: 4.3 og 4.4).
English: 100 milligram ritonavir oral solution: 80 milligram per millilitre
Danish: 100 mg ritonavir oral opløsnig: 80 mg/ml
English: 400 mg film-coated tablets Darunavir Krka d.d.
Danish: 400 mg filmovertrukne tabletter Darunavir Krka d.d.
English: 400 mg film-coated tablets are available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a box.
Danish: 400 mg filmovertrukne tabletter er tilgængelige i beholdere indeholdende 30 filmovertrukne tabletter (1 beholder med 30 filmovertrukne tabletter), 60 filmovertrukne tabletter (2 beholdere med 30 filmovertrukne tabletter), 90 filmovertrukne tabletter (3 beholdere med 30 filmovertrukne tabletter) og 180 filmovertrukne tabletter (6 beholdere med 30 filmovertrukne tabletter) i en æske.
English: Concentrations of these medicinal products may be increased when coadministered with darunavir with low dose ritonavir resulting in the potential for increased adverse events usually associated with these agents.
Danish: Koncentrationerne af disse lægemidler kan øges ved coadministration med darunavir og lavdosis ritonavir, hvilket kan øge risikoen for de bivirkninger, der normalt ses med disse midler.
English: see section 4.5) sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5).
Danish: 4.5) - sildenafil - ved behandling af pulmonal arteriel hypertension, avanafil - simvastatin, lovastatin og lomitapid (se pkt.
English: Darunavir Krka d.d., co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection.
Danish: Darunavir Krka d.d., administreret sammen med lavdosis ritonavir, er i kombination med andre antiretrovirale lægemidler indiceret til behandling af patienter med human immundefektvirus (hiv-1)-infektion.
English: There are some medicines that you must not combine with Darunavir Krka d.d..
Danish: Nogle typer medicin må du ikke tage sammen med Darunavir Krka d.d..
English: is available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a boxes.
Danish: er tilgængelig i beholdere indeholdende 30 filmovertrukne tabletter (1 beholder med 30 filmovertrukne tabletter), 60 filmovertrukne tabletter (2 beholdere med 30 filmovertrukne tabletter), 90 filmovertrukne tabletter (3 beholdere med 30 filmovertrukne tabletter) og 180 filmovertrukne tabletter (6 beholdere med 30 filmovertrukne tabletter) i en æske.
English: The dose is either: 800 milligram Darunavir Krka d.d.
Danish: Dosis er enten: - 800 mg Darunavir Krka d.d.
English: Concomitant administration of boosted darunavir with dabigatran or ticagrelor is contraindicated (see
Danish: Samtidig administration af boostet darunavir og dabigatran eller ticagrelor er kontraindiceret (se pkt.
English: Given that digoxin has a narrow therapeutic index, it is recommended digoxin Cmax ↑ 29% (↑ digoxin from probable inhibition of Pgp)
Danish: digoxin Cmax ↑ 29% (↑ digoxin fra en sandsynlig hæmning af P-gp)
English: The child must take Darunavir Krka d.d.
Danish: - Barnet skal tage Darunavir Krka d.d.
English: Rosuvastatin 10 mg once daily rosuvastatin AUC ↑ 48% rosuvastatin Cmax ↑ 144%
Danish: rosuvastatin AUC ↑ 48%║ rosuvastatin Cmax ↑ 144%║
English: Refer to section 4.4 if creatinine clearance is used for dose adjustment of emtricitabine or lamivudine.
Danish: 4.4, hvis kreatinin-clearance benyttes ved dosisjustering af emtricitabin disse lægemidler og boostet darunavir.
English: Carbamazepine 200 mg twice daily carbamazepine AUC ↑ 45% carbamazepine Cmin ↑ 54% carbamazepine Cmax ↑ 43% darunavir AUC ↔ darunavir Cmin ↓ 15% darunavir Cmax ↔
Danish: Carbamazepin AUC ↑ 45% Carbamazepin Cmin ↑ 54% Carbamazepin Cmax ↑ 43%
English: (2 tablets containing 400 milligram of Darunavir Krka d.d.
Danish: (2 tabletter a 400 mg Darunavir Krka d.d.
English: Saquinavir: comparison of saquinavir/ritonavir 1,000/100 mg twice daily vs. saquinavir/darunavir/ritonavir 1,000/400/100 mg twice daily Darunavir: comparison of darunavir/ritonavir 400/100 mg twice daily vs. darunavir/ritonavir 400/100 mg in combination with saquinavir 1,000 mg twice daily.
Danish: Saquinavir: sammenligning af saquinavir/ritonavir 1.000/100 mg to gange daglig vs saquinavir/darunavir/ritonavir 1.000/400/100 mg to gange daglig Darunavir :sammenligning af darunavir/ritonavir 400/100 mg to gange daglig vs darunavir/ritonavir 400/100 mg to gange daglig i kombination med saquinavir 1.000 mg to gange daglig.
English: ethinylestradiol Cmax  14% with darunavir/cobicistat ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindrone AUC ↓ 14% norethindrone Cmin ↓ 30% norethindrone Cmax ↔ with darunavir/ritonavir
Danish: ethinylestradiol Cmax  14 % med darunavir/cobicistat ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindron AUC ↓ 14% norethindron Cmin ↓ 30%
English: Concomitant use of sildenafil or tadalafil for the treatment of pulmonary arterial hypertension and darunavir coadministered with low dose ritonavir may increase plasma concentrations of sildenafil or tadalafil.
Danish: Samtidig anvendelse af sildenafil eller tadalafil til behandling af pulmonal arteriel hypertension og darunavir co-administreret med lavdosis ritonavir kan øge plasmakoncentrationen af sildenafil og tadalafil.
English: ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindrone AUC ↓ 14% norethindrone Cmin ↓ 30% norethindrone Cmax ↔ with darunavir/ritonavir
Danish: ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindron AUC ↓ 14% norethindron Cmin ↓ 30% norethindron Cmax ↔
English: • For the treatment of HIV-1 infection in antiretroviral treatment (ART)-experienced adult patients, including those that have been highly pre-treated.
Danish: 4.2): - til behandling af hiv-1-infektion hos voksne patienter, som tidligere har været i antiretroviral behandling (ART-erfarne), inklusive patienter, der tidligere har fået omfattende præmedicinering - til behandling af hiv-1-infektion hos pædiatriske patienter fra 3 år med en legemsvægt på mindst 15 kg.
English: (CYP3A, CYP2D6 and/or P-gp inhibition)
Danish: (CYP3A, CYP2D6 og/eller P-gphæmning)
English: Co administration of darunavir coadministered with cobicistat and bosentan is not recommended.
Danish: Co-administration af darunavir coadministreret med cobicistat og bosentan frarådes.
English: For dosage recommendations in ART-naïve patients see the Summary of Product Characteristics for Darunavir Krka d.d.
Danish: Se doseringsanbefalingerne til ART-naive patienter se produktresuméet for Darunavir Krka d.d.
English: Tenofovir disoproxil 245 mg once daily tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% darunavir AUC ↑ 21% darunavir Cmin ↑ 24% darunavir Cmax ↑ 16% (↑ tenofovir from effect on MDR-1 transport in the renal tubules)
Danish: tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% #darunavir AUC ↑ 21% #darunavir Cmin ↑ 24% #darunavir Cmax ↑ 16% (↑ tenofovir fra effekten på MDR-1 transport i de renale tubuli)
English: If parenteral midazolam is co-administered with boosted darunavir it may cause a large increase in the concentration of this benzodiazepine.
Danish: Co-administration af parenteral midazolam med boostet darunavir kan give en kraftig forøgelse af koncentrationen af dette benzodiazepin.
English: One ritonavir a dose is between 15 and 30 kilograms 600 milligram
Danish: En dosis ritonavir a er mellem 15 og 30 kg
English: Based on theoretical considerations boosted darunavir is expected to increase the exposure of lomitapide when coadministered.
Danish: Baseret på teoretiske overvejelser forventes co-administreret boostet darunavir at øge eksponeringen for lomitapid.
English: This can be seen in a blood test. high blood pressure, flushing red or dry eyes fever, swelling of lower limbs due to fluids, malaise, irritability, pain symptoms of infection, herpes simplex erectile dysfunction, enlargement of breasts sleeping problems, sleepiness, depression, anxiety, abnormal dreams, decrease in sexual drive
Danish: knogleskørhed - nedsættelse af skjoldbruskkirtlens funktion.Dette kan ses ved en blodprøve - forhøjet blodtryk, rødme - røde eller tørre øjne - feber, hævede ben på grund af væske, utilpashed, irritabilitet, smerte - symptomer på infektion, herpes simplex - impotens, større bryster - søvnproblemer, søvnighed, depression, angst, unormale drømme, nedgang i seksuallyst.
English: 800 mg film-coated tablets (tablets):
Danish: 800 mg filmovertrukne tabletter (tabletter):
English: Indinavir 800 mg twice daily indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ darunavir AUC ↑ 24% darunavir Cmin ↑ 44% darunavir Cmax ↑ 11%
Danish: Indinavir 800 mg to gange daglig indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ #darunavir AUC ↑ 24% #darunavir Cmin ↑ 44% #darunavir Cmax ↑ 11%