FrancophonIA/ELRC3.0 huggingface dataset:
English: Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle.
Croatian: Dolutegravir inhibira HIV integrazu vezanjem za aktivno mjesto integraze i blokiranjem koraka prijenosa lanca u sklopu integracije retrovirusne deoksiribonukleinske kiseline (DNK), koji je ključan za ciklus replikacije HIV-a.
English: Since lamivudine is dialysable, continuous haemodialysis could be used in the treatment of overdose, although this has not been studied.
Croatian: Budući da se lamivudin može ukloniti dijalizom, predoziranje se može liječiti kontinuiranom hemodijalizom, premda se to nije ispitivalo.
English: The adjusted difference was -2.6 (95% CI: -6.7; 1.5) for GEMINI-1 and0.7 (95% CI: -4.3; 2.9) for GEMINI-2 with a prespecified non-inferiority margin of 10%.
Croatian: Prilagođena razlika iznosila je -2,6 (95% CI: -6,7; 1,5) u ispitivanju GEMINI-1 te -0,7 (95% CI: -4,3;
English: Such infections may have been “silent” and not detected by the weak immune system before treatment was started.
Croatian: Takve su infekcije prije liječenja možda bile „u mirovanju” pa ih oslabljen imunosni sustav nije mogao prepoznati.
English: Adults and adolescents (above 12 years of age weighing at least 40 kg).
Croatian: Doziranje Odrasli i adolescenti (stariji od 12 godina i tjelesne težine od najmanje 40 kg)
English: Some people taking Dovato or other combination treatments for HIV are more at risk of serious side effects than others.
Croatian: U nekih osoba koje uzimaju Dovato ili druge kombinirane terapije za HIV rizik od pojave ozbiljnih nuspojava veći je nego u drugih.
English: Sorbitol solution (3.2 g, 10.2 g, 13.4 g)/Lamivudine
Croatian: Sorbitol otopina sorbitola (3,2 g; 10,2 g; 13,4 g) / lamivudin
English: As dolutegravir is highly bound to plasma proteins, it is unlikely that it will be significantly removed by dialysis.
Croatian: Budući da se dolutegravir u velikoj mjeri veže za proteine u plazmi, nije vjerojatno da će se u značajnoj mjeri ukloniti dijalizom.
English: Thirty-two percent of the total oral dose is excreted in the urine, represented by ether glucuronide of dolutegravir (18.9% of total dose), N-dealkylation metabolite (3.6% of total dose), and a metabolite formed by oxidation at the benzylic carbon (3.0% of total dose).
Croatian: Trideset i dva posto ukupne peroralne doze izlučuje se kroz mokraću u obliku eter-glukuronida dolutegravira (18,9% ukupne doze), metabolita dobivenog N-dealkilacijom (3,6% ukupne doze) i metabolita koji nastaje oksidacijom na benzilnom atomu ugljika (3,0% ukupne doze).
English: The true extent of CNS penetration of lamivudine and its relationship with any clinical efficacy is unknown.
Croatian: Stvarni opseg prodiranja lamivudina u središnji živčani sustav i povezanost toga s kliničkom djelotvornošću nisu poznati.
English: Dolutegravir belongs to a group of anti-retroviral medicines called integrase inhibitors (INIs), and lamivudine belongs to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Croatian: Dolutegravir pripada skupini antiretrovirusnih lijekova koji se nazivaju inhibitori integraze, a lamivudin pripada skupini antiretrovirusnih lijekova koji se zovu nukleozidni analozi inhibitora reverzne transkriptaze (engl. nucleoside analogue reverse transcriptase inhibitors, NRTI).
English: Exposure to dolutegravir was generally similar between healthy subjects and HIV-1-infected subjects.
Croatian: Izloženost dolutegraviru u načelu je bila slična kod zdravih ispitanika i ispitanika s HIV-1 infekcijom.
English: Based on this data, dolutegravir is not expected to affect the pharmacokinetics of medicinal products that are substrates of major enzymes or transporters (see section 4.5).
Croatian: Na temelju tih podataka, ne očekuje se da će dolutegravir utjecati na farmakokinetiku lijekova koji su supstrati za glavne enzime ili prijenosnike (vidjeti dio 4.5).
English: pure red cell aplasia
Croatian: izolirana aplazija crvenih krvnih stanica
English: No relevant effects were seen with dolutegravir on the QTc interval, with doses exceeding the clinical dose by approximately three fold.
Croatian: Nisu primijećeni značajni učinci dolutegravira na QTc interval kod primjene doza približno trostruko većih od kliničke doze.
English: United Kingdom ViiV Healthcare UK Limited Tel: + 44 (0)800 221441 customercontactuk@gsk.com
Croatian: ViiV Healthcare UK Limited Tel: + 44 (0)800 221441 customercontactuk@gsk.com
English: The pharmacokinetics of dolutegravir following single dose oral administration to Japanese subjects appear similar to observed parameters in Western (US) subjects.
Croatian: Farmakokinetički parametri dolutegravira nakon peroralne primjene jedne doze u ispitanika japanskoga podrijetla čine se sličnima parametrima opaženima u ispitanika sa zapada (SAD).
English: But if your next dose is due within 4 hours, skip the dose you missed and take the next one at the usual time.
Croatian: Međutim, ako je do sljedeće doze preostalo manje od 4 sata, preskočite propuštenu dozu i uzmite sljedeću dozu u uobičajeno vrijeme.
English: AUC in semen was 7% and 17% in rectal tissue of those in corresponding plasma at steady state.
Croatian: AUC je u sjemenu iznosio 7%, a u rektalnom tkivu 17% odgovarajuće vrijednosti u plazmi u stanju dinamičke ravnoteže.
English: In a meta-analysis using pharmacogenomics samples collected in clinical studies in healthy subjects, subjects with UGT1A1 (n=7) genotypes conferring poor dolutegravir metabolism had a 32% lower clearance of dolutegravir and 46% higher AUC compared with subjects with genotypes associated with normal metabolism via UGT1A1 (n=41).
Croatian: U metaanalizi farmakogenomskih uzoraka prikupljenih u kliničkim ispitivanjima provedenima u zdravih osoba, ispitanici s genotipovima UGT1A1 (n=7) koji su povezani sa slabim metabolizmom dolutegravira imali su 32% manji klirens dolutegravira i 46% veći AUC u usporedbi s ispitanicima s genotipovima koji su povezani s normalnim metabolizmom putem UGT1A1 (n=41).
English: Immune response syndrome
Croatian: Sindrom imunološkog odgovora
English: Dolutegravir and lamivudine are present in cerebrospinal fluid (CSF).
Croatian: Dolutegravir i lamivudin pronađeni su u cerebrospinalnoj tekućini.
English: In vitro, dolutegravir did not induce CYP1A2, CYP2B6 or CYP3A4.
Croatian: In vitro dolutegravir nije inducirao CYP1A2, CYP2B6 ni CYP3A4.
English: Dovato should not be co-administered with polyvalent cation-containing antacids.
Croatian: Dovato se ne smije primjenjivati istodobno s antacidima koji sadrže polivalentne katione.
English: Preliminary data from a surveillance study has suggested an increased incidence of neural tube defects (0.9%) in mothers exposed to dolutegravir (a component of Dovato) at the time of conception compared with mothers exposed to non-dolutegravir containing regimens (0.1%).
Croatian: Preliminarni podaci iz ispitivanja s ciljem praćenja ukazali su na povećanu incidenciju oštećenja neuralne cijevi (0,9%) u djece čije su majke u vrijeme začeća bile izložene dolutegraviru (jednoj od sastavnica lijeka Dovato) u odnosu na djecu čije su majke bile izložene režimima koji nisu sadržavali dolutegravir (0,1%).
English: • oxcarbazepine and carbamazepine, to treat epilepsy or bipolar disorder
Croatian: • okskarbazepin i karbamazepin, koji se koriste za liječenje epilepsije ili bipolarnog poremećaja
English: Opaque, white HDPE (high density polyethylene) bottles closed with child resistant polypropylene closures, with a polyethylene faced induction heat seal liner.
Croatian: Neprozirne, bijele boce od polietilena visoke gustoće (HDPE) zatvorene polipropilenskim zatvaračima sigurnima za djecu i polietilenskom toplinski zalijepljenom zaštitnom folijom.
English: Following multipledose oral administration of lamivudine 300 mg once daily for seven days, the mean (CV) steady-state Cmax is 2.04 µg/mL (26%) and the mean (CV) AUC(0-24) is 8.87 µg.h/mL (21%).
Croatian: Nakon peroralne primjene višekratnih doza lamivudina od 300 mg jedanput na dan tijekom sedam dana, srednja vrijednost (CV) Cmax u stanju dinamičke ravnoteže iznosi 2,04 µg/ml (26%), a srednja vrijednost (CV) AUC(0-24) 8,87 µg.h/ml (21%).
English: Mitochondrial dysfunction following exposure in utero
Croatian: Mitohondrijska disfunkcija nakon izlaganja lijeku in utero
English: Metabolism of lamivudine is a minor route of elimination.
Croatian: Metabolizam je sporedan put eliminacije lamivudina.
English: • metformin, to treat diabetes
Croatian: • metformin, koji se koristi za liječenje šećerne bolesti
English: For Dovato, the median time to maximal plasma concentration (tmax) is 2.5 hours for dolutegravir and 1.0 hour for lamivudine, when dosed under fasted conditions.
Croatian: Kod primjene lijeka Dovato medijan vremena do postizanja maksimalne plazmatske koncentracije (tmax) iznosi 2,5 sati za dolutegravir te 1,0 sati za lamivudin, kada se lijek primjenjuje natašte.
English: • phenytoin and phenobarbital, to treat epilepsy
Croatian: • fenitoin i fenobarbital, koji se koriste za liječenje epilepsije
English: Available toxicological data in animals has shown excretion of dolutegravir in milk.
Croatian: Dostupni toksikološki podaci prikupljeni u životinja pokazuju da se dolutegravir izlučuje u mlijeko.
English: • a low red blood cell count (anaemia) or low white blood cell count (neutropenia).
Croatian: • smanjen broj stanica koje sudjeluju u zgrušavanju krvi (trombocitopenija) • nizak broj crvenih krvnih stanica (anemija) ili nizak broj bijelih krvnih stanica (neutropenija)
English: Total blood and plasma drugrelated radioactivity concentration ratios averaged between 0.441 to 0.535, indicating minimal association of radioactivity with blood cellular components.
Croatian: 0,441 i 0,535, što ukazuje na minimalnu povezanost radioaktivnosti s krvnim stanicama.
English: When possible, avoid chronic coadministration of Dovato with medicinal products containing sorbitol or other osmotic acting poly-alcohols or monosaccharide alcohols (eg: xylitol, mannitol, lactitol, maltitol).
Croatian: Ako je moguće, treba izbjegavati dugotrajnu istodobnu primjenu lijeka Dovato s lijekovima koji sadrže sorbitol ili neki drugi polialkohol ili monosaharidni alkohol s osmotskim djelovanjem (npr. ksilitol, manitol, laktitol, maltitol).
English: If the next dose is due within 4 hours, the patient should not take the missed dose and simply resume the usual dosing schedule.
Croatian: Ako je do sljedeće doze preostalo manje od 4 sata, bolesnik ne smije uzeti propuštenu dozu, nego samo nastaviti s primjenom lijeka prema uobičajenom rasporedu.
English: Magnesium/ aluminium-containing antacids should be taken well separated in time from the administration of Dovato (minimum 2 hours after or 6 hours before).
Croatian: Antacide koji sadrže magnezij/aluminij treba uzimati sa značajnim vremenskim odmakom u odnosu na primjenu lijeka Dovato (najmanje 2 sata nakon ili 6 sati prije).
English: Pharmacotherapeutic group: Antivirals for systemic use, antivirals for treatment of HIV infections, combinations.
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: Antivirotici za sistemsku primjenu, antivirotici za liječenje HIV infekcije,
English: - If Dovato is taken in a fasted state, such supplements should be taken a minimum 2 hours after or 6 hours before the intake of Dovato.
Croatian: - Ako se Dovato uzima natašte, takve dodatke prehrani treba uzeti najmanje 2 sata nakon ili 6 sati prije uzimanja lijeka Dovato.
English: For lipids, there is in some cases evidence for a treatment effect, while for weight gain there is no strong evidence relating this to any particular treatment.
Croatian: U nekim slučajevima postoje dokazi o učinku liječenja na vrijednosti lipida, no nema čvrstih dokaza koji povezuju povećanje tjelesne težine s bilo kojim konkretnim liječenjem.
English: Multivitamins (containing calcium, iron and magnesium) /Dolutegravir (fasted intake)
Croatian: multivitaminski pripravci (koji sadrže kalcij, željezo i magnezij) / dolutegravir (kada se uzima natašte)
English: Limited data are available in adolescents receiving a daily dose of 300 mg of lamivudine.
Croatian: Dostupni su ograničeni podaci o primjeni lamivudina u dnevnoj dozi od 300 mg u adolescenata.
English: WOCBP who are taking Dovato should use effective contraception throughout treatment.
Croatian: Žene reproduktivne dobi koje uzimaju Dovato trebaju koristiti učinkovitu metodu kontracepcije tijekom čitavog liječenja.
English: If you take too many tablets of Dovato contact your doctor or pharmacist for advice.
Croatian: Ako uzmete previše tableta lijeka Dovato, obratite se svom liječniku ili ljekarniku za savjet.
English: The recommended dose of dolutegravir is 50 mg twice daily when co-administered with rifampicin, carbamazepine, oxcarbazepine, phenytoin, phenobarbital, St. John's wort, etravirine (without boosted protease inhibitors), efavirenz, nevirapine, or tipranavir/ritonavir (see section 4.5).
Croatian: Preporučena doza dolutegravira je 50 mg dvaput na dan kada se primjenjuje istodobno s rifampicinom, karbamazepinom, okskarbazepinom, fenitoinom, fenobarbitalom, gospinom travom, etravirinom (bez pojačanih inhibitora proteaze), efavirenzom, nevirapinom ili tipranavirom/ritonavirom (vidjeti dio 4.5).
English: Dovato and other suspect medicinal products should be discontinued immediately if signs or symptoms of hypersensitivity reactions develop (including, but not limited to, severe rash or rash accompanied by raised liver enzymes, fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, facial oedema, eosinophilia, angioedema).
Croatian: Primjena lijeka Dovato i drugih suspektnih lijekova mora se odmah prekinuti ako se pojave znakovi ili simptomi reakcija preosjetljivosti (uključujući, između ostaloga, težak osip ili osip praćen povišenim vrijednostima jetrenih enzima, vrućicu, opću malaksalost, umor, bolove u mišićima ili zglobovima, mjehuriće, oralne lezije, konjunktivitis, edem lica, eozinofiliju i angioedem).
English: Data in window and ≥50 copies/mL
Croatian: Razlozi Podaci u promatranom razdoblju i ≥ 50 kopija/ml
English: • St. John's wort (Hypericum perforatum), a herbal remedy to treat depression.
Croatian: • gospinu travu (Hypericum perforatum), biljni lijek koji se koristi za liječenje depresije
English: Each bottle contains 30 film-coated tablets.
Croatian: Jedan boca sadrži 30 filmom obloženih tableta.
English: Transmission of HIV
Croatian: HIV infekcije
English: Effect of other medicinal products on the pharmacokinetics of dolutegravir and lamivudine
Croatian: Učinci drugih lijekova na farmakokinetiku dolutegravira i lamivudina
English: There have been reports of mitochondrial dysfunction in HIV-negative infants exposed in utero and/or post-natally to nucleoside analogues (see section 4.4).
Croatian: Prijavljeni su slučajevi mitohondrijske disfunkcije u HIV negativne dojenčadi koja je bila izložena nukleozidnim analozima in utero i/ili nakon rođenja (vidjeti dio 4.4).
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse reactions.
Croatian: Bolesnici s kroničnim hepatitisom B ili C koji se liječe kombiniranom antiretrovirusnom terapijom izloženi su povećanom riziku od teških jetrenih nuspojava, koje mogu imati smrtni ishod.
English: Dovato may be administered with or without food.
Croatian: Dovato se može primjenjivati s hranom ili bez nje.
English: Etravirine without boosted protease inhibitors decreased plasma dolutegravir concentration.
Croatian: Etravirin bez pojačanih inhibitora proteaze smanjio je koncentraciju dolutegravira u plazmi.
English: The mean systemic clearance of lamivudine is approximately 0.32 L/h/kg, predominantly by renal clearance (> 70%) via the organic cationic transport system.
Croatian: Srednja vrijednost sistemskog klirensa lamivudina iznosi približno 0,32 l/h/kg, a najvećim se dijelom odvija kroz bubrege (> 70%) posredstvom sustava prijenosa organskih kationa.
English: A study of the pharmacokinetics of dolutegravir was performed in subjects with severe renal impairment (CLcr <30 mL/min).
Croatian: Ispitivanje farmakokinetike dolutegravira provedeno je u ispitanika s teškim oštećenjem bubrežne funkcije (CLcr < 30 ml/min).
English: At baseline, in the pooled analysis, the median age of subjects was 33 years, 15% were female, 68% were white, 9% were CDC Stage 3 (AIDS), 20% had HIV-1 RNA >100,000 copies/mL, and 8% had CD4+ cell count less than 200 cells per mm3; these characteristics were similar between studies and treatment arms.
Croatian: 33 godine, 15% ispitanika bile su žene, 68% ispitanika bili su bijelci, 9% imalo je infekciju kategorije 3 prema CDC klasifikaciji (AIDS), 20% imalo je koncentraciju HIV-1 RNK > 100 000 kopija/ml, a 8% ispitanika imalo je broj CD4+ stanica manji od 200 stanica/mm3.
English: Dolutegravir and lamivudine are rapidly absorbed following oral administration.
Croatian: Dolutegravir i lamivudin brzo se apsorbiraju nakon peroralne primjene.
English: In rare cases, as the immune system becomes stronger, it can also attack healthy body tissue (autoimmune disorders).
Croatian: Kako postaje snažniji, imunosni sustav u rijetkim slučajevima može napasti i zdravo tkivo (autoimuni poremećaji).
English: The mean IC50 for 3 HIV-2 isolates was 0.18 nM (range 0.09-0.61).
Croatian: Srednja vrijednost IC50 za 3 izolata HIV-2 iznosila je 0,18 nM (raspon: 0,09 - 0,61).
English: The mean ratio of CSF/serum lamivudine concentrations 2-4 hours after oral administration was approximately 12%.
Croatian: Srednja vrijednost omjera koncentracija lamivudina u cerebrospinalnoj tekućini i serumu 2 - 4 sata nakon peroralne primjene iznosila je približno 12%.
English: Pooled analysis also stratified by study.
Croatian: Analiza objedinjenih podataka stratificirana je i prema ispitivanju.
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
Croatian: Budući da je u bolesnika s otprije postojećom jetrenom disfunkcijom, uključujući kronični aktivni hepatitis, zabilježena povećana učestalost poremećaja jetrene funkcije tijekom kombinirane antiretrovirusne terapije, te bolesnike treba nadzirati u skladu sa standardnom praksom.
English: In vitro, dolutegravir demonstrated no direct, or weak inhibition (IC50>50 μM) of the enzymes cytochrome P450 (CYP)1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 CYP3A, UGT1A1 or UGT2B7, or the transporters Pgp, BCRP, BSEP, organic anion transporting polypeptide (OATP) 1B1, OATP1B3, OCT1, MATE2-K, multidrug resistance-associated protein (MRP) 2 or MRP4.
Croatian: In vitro dolutegravir nije pokazao ni izravnu ni slabu inhibiciju (IC50 > 50 μM) enzima citokroma P450 (CYP)1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A, UGT1A1 i UGT2B7 ni prijenosnika P-gp, BCRP, pumpe za izlučivanje žučnih soli (engl. bile salt export pump, BSEP), polipeptidnog prijenosnika organskih aniona OATP1B1, OATP1B3, OCT1, MATE2-K, proteina koji uzrokuje rezistenciju na veći broj lijekova 2 (engl. multidrug resistance-associated protein 2, MRP2) i MRP4.
English: No dose adjustment of oral contraceptives is necessary when co-administered with Dovato.
Croatian: Nije potrebno prilagođavati dozu oralnih kontraceptiva kod istodobne primjene s lijekom Dovato.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Croatian: Lamivudin nije bio teratogen u ispitivanjima na životinjama, ali je bilo znakova koji su ukazivali na porast rane smrtnosti embrija u kunića pri relativno niskim razinama sistemske izloženosti,
English: vomiting, flatulence, abdominal pain/ discomfort
Croatian: povraćanje, flatulencija, bol/nelagoda u abdomenu
English: Titanium dioxide (E171)
Croatian: Ovojnica tablete hipromeloza (E464) makrogol titanijev dioksid (E171)
English: None of the six subjects in the dolutegravir plus lamivudine group or the four subjects in the dolutegravir plus tenofovir disoproxil/emtricitabine FDC group that met virological withdrawal criteria through Week 48 across the GEMINI-1 (204861) and GEMINI-2 (205543) studies had treatment emergent integrase inhibitor or NRTI class resistance.
Croatian: Ni u jednog od 6 ispitanika iz skupine koja je primala dolutegravir plus lamivudin, odnosno 4 ispitanika iz skupine koja je primala dolutegravir plus kombinaciju fiksnih doza tenofovirdizoproksila/emtricitabina, a koji su zadovoljili kriterije za virološki neuspjeh do 48. tjedna u ispitivanjima GEMINI-1 (204861) i GEMINI-2 (205543) nije došlo do razvoja rezistencije na skupinu inhibitora integraze ni na skupinu NRTI-ja tijekom liječenja.
English: Based on limited available data with the dolutegravir single entity or lamivudine single entity used in combination with other antiretroviral agents to treat adolescents (12 to 17 years), there were no additional types of adverse reactions beyond those observed in the adult population.
Croatian: Ograničeni dostupni podaci o zasebnoj primjeni dolutegravira odnosno zasebnoj primjeni lamivudina u kombinaciji s drugim antiretroviroticima za liječenje adolescenata (u dobi od 12 do 17 godina) nisu ukazali na dodatne vrste nuspojava u odnosu na one primijećene u odrasloj populaciji.
English: Due to the potential risk of neural tube defects with dolutegravir, Dovato should not be used during the first trimester unless there is no alternative.
Croatian: Zbog mogućeg rizika od oštećenja neuralne cijevi kod primjene dolutegravira, Dovato se ne smije koristiti u prvom tromjesečju trudnoće, osim u slučajevima kada nisu dostupne druge mogućnosti liječenja.
English: Psychiatric disorders: Common:
Croatian: Psihijatrijski poremećaji: Često:
English: Based on the lamivudine data, Dovato is not recommended for patients with creatinine clearance of < 50 mL/min.
Croatian: S obzirom na podatke za lamivudin, ne preporučuje se primjena lijeka Dovato u bolesnika s klirensom kreatinina < 50 ml/min.
English: • symptoms of infections and inflammation
Croatian: • simptome infekcija i upala
English: In HIV-1-infected adult subjects following dolutegravir 50 mg once daily, the steady-state pharmacokinetic parameters (geometric mean [%CV]) based on population pharmacokinetic analyses were AUC(0-24) = 53.6 (27) µg.h/mL, Cmax = 3.67 (20) µg/mL, and Cmin = 1.11 (46) µg/mL.
Croatian: infekcijom, farmakokinetički parametri u stanju dinamičke ravnoteže (geometrijska srednja vrijednost [% koeficijenta varijacije - CV]) utvrđeni na temelju populacijske farmakokinetičke analize bili su sljedeći: AUC(0-24) = 53,6 (27) µg.h/ml, Cmax = 3,67 (20) µg/ml i Cmin = 1,11 (46) µg/ml.
English: Metformin is eliminated renally and, therefore, it is of importance to monitor renal function when co-treated with Dovato.
Croatian: Metformin se izlučuje putem bubrega te je stoga važno nadzirati bubrežnu funkciju kada se primjenjuje istodobno s lijekom Dovato.
English: • itching (pruritus)
Croatian: • osip • svrbež (pruritus)
English: Subjects were randomised to a two-drug regimen of dolutegravir 50 mg plus lamivudine 300 mg once daily or dolutegravir 50 mg plus tenofovir disoproxil/emtricitabine 245/200 mg once daily.
Croatian: Ispitanici su bili randomizirani za dvojni režim liječenja koji je uključivao dolutegravir u dozi od 50 mg i lamivudin u dozi od 300 mg jedanput na dan ili dolutegravir u dozi od 50 mg i tenofovirdizoproksil/emtricitabin u dozi od 245/200 mg jedanput na dan.
English: Fertility studies in rats have shown that dolutegravir or lamivudine have no effect on male or female fertility.
Croatian: Ispitivanja plodnosti na štakorima pokazala su da dolutegravir i lamivudin ne utječu na plodnost mužjaka ni ženki.