FrancophonIA/ELRC3.0 huggingface dataset:
English: The high intra-individual variability of the coagulation state during malignancy, and the potential interaction between oral anticoagulants and anticancer chemotherapy require, if it is decided to treat the patient with oral anticoagulants, to increase the frequency of the INR (International Normalised Ratio) monitoring.
Croatian: Velika varijabilnost stanja koagulacije u svakog pojedinca s malignom bolešću, kao i potencijalne interakcije između oralnih antikoagulansa i antitumorskih lijekova zahtijevaju češće praćenje INR (International Normalised Ratio) u bolesnika liječenih oralnim antikoagulansima.
English: Engraftment: It has been achieved with all evaluated conditioning regimens including thiotepa with a success rate of 96% - 100%.
Croatian: Prihvat transplantata: Prihvat je postignut kod svih procijenjenih pripremnih liječenja s tiotepom, sa stopom uspjeha od 96% - 100%.
English: TEPADINA must be delivered after the completion of any cyclophosphamide infusion.
Croatian: TEPADINA se mora koristiti tek nakon završetka svake infuzije s ciklofosfamidom.
English: The elimination half-life varied from 1.5 to 4.1 hours.
Croatian: 1,5 do 4,1 sati.
English: Thiotepa is a weak inhibitor for CYP2B6, and may thereby potentially increase plasma concentrations of substances metabolised via CYP2B6, such as ifosfamide, tamoxifen, bupropion, efavirenz and cyclophosphamide.
Croatian: Tiotepa je slab inhibitor CYP2B6 i na taj način može povećati plazmatske koncentracije tvari metaboliziranih putem CYP2B6, kao što su ifosfamid, tamoksifen, bupropion, efavirenz i ciklofosfamid.
English: The administration of thiotepa has not been specifically investigated in elderly patients.
Croatian: Primjena tiotepe nije posebno proučavana kod starijih bolesnika.
English: Phenytoin: risk of exacerbation of convulsions resulting from the decrease of phenytoin digestive absorption by cytotoxic medicinal product or risk of toxicity enhancement and loss of efficacy of the cytotoxic medicinal product due to increased hepatic metabolism by phenytoin.
Croatian: Fenitoin: rizik za egzacerbaciju konvulzija zbog smanjene probavne apsorpcije fenitoina inducirane citotoksičnim lijekovima ili rizik za povećanu toksičnost i gubitak djelotvornosti citotoksičnog lijeka zbog pojačanog metabolizma u jetri uzrokovanog fenitoinom.
English: It was teratogenic in mice and in rats, and foeto-lethal in rabbits.
Croatian: Ona je teratogena u miševa i štakora, a smrtonosna za fetus u kunića.
English: After reconstitution, use within 8 hours when stored in a refrigerator.
Croatian: Nakon pripreme za primjenu, primijeniti u roku od 8 sati, ako se čuva u hladnjaku.
English: In pre-clinical studies thiotepa, as most alkylating agents, has been shown to cause embryofoetal lethality and teratogenicity (see section 5.3).
Croatian: U pretkliničkim studijama tiotepa, kao i većina alkilirajućih agensa, je uzrokovala smrtnost embrija i fetusa te je imala teratogeno djelovanje (vidjeti dio 5.3).
English: The identified metabolites TEPA, monochlorotepa and thiotepa-mercapturate are all excreted in the urine.
Croatian: Identificirani metaboliti TEPA, monoklorotepa i tiotepa merkapturata se svi izlučuju u mokraći.
English: Thiotepa was shown to be genotoxic in vitro and in vivo, and carcinogenic in mice and rats.
Croatian: Dokazana je genotoksičnost tiotepe in vitro i in vivo, i njegova kancerogenost u miševa i štakora.
English: TEPADINA must be delivered after the completion of any cyclophosphamide infusion (see section 4.5).
Croatian: TEPADINA se mora primijeniti tek nakon završetka svake infuzije s ciklofosfamidom (vidjeti dio 4.5).
English: Cardiovascular insufficiency Cardiac failure
Croatian: Kardiovaskularna insuficijencija Zatajenje srca
English: Posology in paediatric patients
Croatian: Doziranje u pedijatrijskih bolesnika
English: (10 mg/kg), during the time of the entire conditioning treatment.
Croatian: (10 mg/kg), tijekom cijelog pripremnog liječenja.
English: In some of the conditioning treatments evaluated, relapse rates lower than 60% have also been reported at 5 years.
Croatian: U nekim od procijenjivanih pripremnih terapija zabilježene su stope recidiva manje od 60% i nakon 5 godina.
English: Inject the content of the syringe into the vial through the rubber stopper.
Croatian: Ubrizgajte sadržaj štrcaljke u bočicu kroz gumeni čep.
English: There is no experience with overdoses of thiotepa.
Croatian: Nema iskustava s predoziranjem tiotepom.
English: Considering that all patients suffer of recurrence or poor prognosis solid tumours, these rates support the efficacy of conditioning regimens based on thiotepa.
Croatian: Budući da su svi bolesnici liječeni od recidivirajućih solidnih tumora loše prognoze, ove stope potvrđuju djelotvornost pripremnih terapija koje se temelje na tiotepi.
English: As most alkylating agents, thiotepa might impair male or female fertility.
Croatian: Poput većine alkilirajućih agensa, tiotepa može utjecati na mušku ili žensku plodnost.
English: The most serious side effects of TEPADINA therapy or the transplant procedure may include - decrease in circulating blood cell counts (intended effect of the medicine to prepare you for your transplant infusion) - infection - liver disorders including blocking of a liver vein - the graft attacks your body (graft versus host disease) - respiratory complications
Croatian: Najozbiljnije nuspojave terapije s lijekom TEPADINA ili postupka transplantacije mogu uključivati: - smanjenje broja cirkulirajućih krvnih stanica (željeni učinak lijeka kako bi Vas pripremio za infuziju za transplantaciju) - infekcija - poremećaji jetre, uključujući i opstrukciju jedne od vena jetre - stanice presatka napadaju tijelo (bolest presatka protiv domaćina) - dišne komplikacije
English: TEPADINA is administered by a qualified healthcare professional as an intravenous infusion (drip in a vein) after dilution of the individual vial.
Croatian: TEPADINA se primjenjuje od strane zdravstvenog djelatnika kao intravenska infuzija (kapanje u venu) nakon razrjeđivanja pojedinačne bočice.
English: In some cases, relapse rates lower than 40% have also been reported at 5 years and 10 years.
Croatian: U nekim slučajevima, prijavljene su stope recidiva manje od 40% nakon 5 i 10 godina.
English: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Croatian: Dobroćudni, zloćudni i nespecificirane novotvorine (uključujući ciste i polipe)
English: TEPADINA administration must be supervised by a physician experienced in conditioning treatment prior to haematopoietic progenitor cell transplantation.
Croatian: Primjena lijeka TEPADINA mora biti pod nadzorom liječnika s iskustvom u pripremnom liječenju prije transplantacije hematopoetskih matičnih stanica.
English: Not known: frequency cannot be estimated from the available data - increased blood pressure in the arteries (blood vessels) of the lungs (pulmonary arterial hypertension) - severe skin damage (e.g. severe lesions, bullae, etc.) potentially involving the full body surface which can be even life-threatening - damage to a component of the brain (the so called white matter) which can be even lifethreatening (leukoencephalopathy).
Croatian: Nepoznato: učestalost se ne može procijeniti iz dostupnih podataka - povišen krvni tlak u arterijama (krvnim žilama) pluća (plućna arterijska hipertenzija) - teško oštećenje kože (npr. teške lezije, mjehuri itd.) koje može zahvatiti površinu cijeloga tijela te čak biti opasno po život - oštećenje dijela mozga (tzv. bijele tvari) koje može biti i opasno po život (leukoencefalopatija).
English: Since thiotepa is mainly metabolized through the liver, caution needs to be observed when thiotepa is used in patients with preexisting impairment of liver function, especially in those with severe hepatic impairment.
Croatian: Budući da se tiotepa uglavnom metabolizira putem jetre, treba biti oprezan kada se ista koristi kod bolesnika s već postojećim oštećenjem funkcije jetre, posebice kod onih s teškim oštećenjem funkcije jetre.
English: TEPADINA must be administered by a qualified healthcare professional as a 2-4 hours intravenous infusion via a central venous catheter.
Croatian: Primjena lijeka TEPADINA mora biti provedena od strane kvalificiranog medicinskog osoblja preko intravenske infuzije u trajanju od 2-4 sata, putem središnjeg venskog katetera.
English: Relapse: In all the reported conditioning regimens containing thiotepa, relapse rates at 12 to 57 months ranged from 33% to 57%.
Croatian: Recidiv: Uz sva pripremna liječenja s tiotepom zabilježene stope recidiva nakon 12 do 57 mjeseci su bile u rasponu od 33% do 57%.
English: As alkylating agent, thiotepa produces the most profound inhibition of tumour cell growth in vitro with the smallest increase in medicinal product concentration.
Croatian: Kao alkilirajući agens, tiotepa uzrokuje najjaču inhibiciju rasta tumorskih stanica in vitro s minimalnim povećanjem koncentracije lijeka.
English: 20867 Caponago (MB) Italy adienne@adienne.com
Croatian: 20867 Caponago (MB) Italija adienne@adienne.com
English: Thiotepa is unreliably absorbed from the gastrointestinal tract: acid instability prevents thiotepa from being administered orally.
Croatian: Apsorpcija tiotepe u gastrointestinalnom traktu je nepouzdana: nestabilnost u kiselom mediju sprječava peroralnu primjenu tiotepe.
English: INSTRUCTIONS ON USE
Croatian: UPUTE ZA PRIPREMU
English: CYP2B6 catalyzes the metabolic conversion of cyclophosphamide to its active form 4-hydroxycyclophosphamide (4-OHCP) and co-administration of thiotepa may therefore lead to decreased concentrations of the active 4-OHCP.
Croatian: CYP2B6 katalizira metaboličku pretvorbu ciklofosfamida u njegov aktivni oblik 4hidroksiciklofosfamid (4-OHCP) i stoga istodobna upotreba s tiotepom može dovesti do smanjenja koncentracije aktivnog 4-OCHP.
English: Concomitant use with yellow fever vaccine and with live virus and bacterial vaccines (see section 4.5).
Croatian: Istodobna primjena cjepiva protiv žute groznice i cjepiva sa živim virusima i bakterijama (vidjeti dio
English: Thiotepa is a polyfunctional cytotoxic agent related chemically and pharmacologically to the nitrogen mustard.
Croatian: Tiotepa je citotoksični agens polifunkcionalnog tipa, kemijski i farmakološki povezan s dušikovim iperitom.
English: Blood bilirubin increased Transaminases increased Blood creatinine increased Aspartate aminotransferase increased Alanine aminotransferase increased
Croatian: Povećanje kreatinina u krvi Povećanje aspartat aminotransferaze Povećanje alanin aminotransferaze
English: TEPADINA should be aseptically administered as a 2-4 hours infusion under room temperature (about 25°C) and normal light conditions.
Croatian: TEPADINA se mora aseptički primijeniti putem infuzije u trajanju od 2-4 sati na sobnoj temperaturi (oko 25 °C) i u uobičajenim uvjetima osvjetljenja.
English: Accord Healthcare GmbH Tel: +49 89 700 9951 0
Croatian: Deutschland Accord Healthcare GmbH Tel: +49 89 700 9951 0
English: Other medicines and TEPADINA
Croatian: Drugi lijekovi i TEPADINA
English: Transaminases increased
Croatian: Povećanje transaminaza
English: TEPADINA is administered at different doses in combination with other chemotherapeutic medicinal products in patients prior to conventional haematopoietic progenitor cell transplantation (HPCT) for haematological diseases or solid tumours.
Croatian: TEPADINA se primjenjuje u različitim dozama u kombinaciji s drugim kemoterapeutskim lijekovima kod bolesnika prije konvencionalne transplantacije hematopoetskih matičnih stanica (TKMS) za hematološke bolesti ili solidne tumore.
English: Remove the syringe and the needle and mix manually by repeated inversions.
Croatian: Uklonite špricu i iglu te ručno promiješajte tako da bočicu više puta preokrenete.
English: There are no data on the use of thiotepa during pregnancy.
Croatian: Nema podataka o primjeni tiotepe u trudnoći.
English: The concomitant use of thiotepa and other myelosuppressive or myelotoxic agents (i.e. cyclophosphamide, melphalan, busulfan, fludarabine, treosulfan) may potentiate the risk of haematologic adverse reactions due to overlapping toxicity profiles of these medicinal products.
Croatian: Istodobna primjena tiotepe i drugih mijelosupresivnih ili mijelotoksičnih lijekova (npr. ciklofosfamid, melfalan, busulfan, fludarabin, treosulfan) može povećati rizik od hematoloških nuspojava zbog preklapanja toksičnih profila tih lijekova.
English: Severe granulocytopenia, thrombocytopenia, anaemia or any combination thereof may develop.
Croatian: Mogu se razviti teška granulocitopenija, trombocitopenija, anemija ili bilo koja od kombinacija prethodno spomenutih stanja.
English: 20867 Caponago (MB) Italy Tel: +39-02 40700445 adienne@adienne.com
Croatian: 20867 Caponago (MB) Italija Tel: +39-02 40700445 adienne@adienne.com
English: More generally, live virus and bacterial vaccines must not be administered to a patient receiving an immunosuppressive chemotherapeutic agent and at least three months must elapse between discontinuation of therapy and vaccination.
Croatian: Općenito, ne treba upotrebljavati cjepiva sa živim virusima i bakterijama u bolesnika koji se liječe s imunosupresivnim kemoterapeuticima, i moraju proći najmanje tri mjeseca od prestanka terapije do cijepljenja.
English: Considering that all patients were treated for high risk solid tumours, DFS results confirm that conditioning treatments containing thiotepa following autologous HPCT are effective therapeutic strategies for treating paediatric patients with solid tumours.
Croatian: Budući da su svi bolesnici liječeni zbog solidnih tumora visokog rizika, rezultati DFS potvrđuju da su pripremna liječenja s tiotepom nakon kojih slijedi autologna TKMS učinkovite terapijske strategije za liječenje pedijatrijskih bolesnika sa solidnim tumorima.
English: Thiotepa undergoes oxidative desulphuration via the cytochrome P450 CYP2B and CYP3A isoenzyme families to the major and active metabolite TEPA (triethylenephosphoramide).
Croatian: Tiotepa je podložna oksidacijskoj desulfurizaciji putem citokrom P450 CYP2B i CYP3A obitelji izoenzima sve do aktivnog metabolita TEPA (trietilenefosforamid).
English: As thiotepa and its metabolites are poorly excreted in the urine, dose modification is not recommended in patients with mild or moderate renal insufficiency.
Croatian: Kako se tiotepa i njegovi metaboliti slabo izlučuju mokraćom, promjena doziranja se ne preporučuje u bolesnika s blagom ili umjerenom bubrežnom insuficijencijom.
English: Cardiomyopathy Myocarditis
Croatian: Kardiomiopatija Miokarditis
English: TEPADINA must be reconstituted and diluted prior to administration.
Croatian: TEPADINA mora biti rekonstruirana i razrijeđena prije primjene.
English: Thiotepa has marrow ablation as its dose-limiting toxicity, allowing significant dose escalation with the infusion of autologous HPCT.
Croatian: Za tiotepu je ablacija koštane srži dozno-ograničavajuća toksičnost, što omogućuje značajno povećanje doze s infuzijom autologne TKMS.
English: Store and transport refrigerated (2°C-8°C).
Croatian: Čuvati i prevoziti na hladnom (2°C-8°C).
English: Regimen Related Mortality (RRM) and Transplant Related Mortality (TRM): low values have been reported, confirming the safety of the conditioning treatments including thiotepa for allogeneic HPCT in adult patients with haematological diseases.
Croatian: Mortalitet vezan za terapiju (RRM - Regimen Related Mortality ) i mortalitet vezan za transplantaciju (TRM - Transplant Related Mortality): prijavljene su niske vrijednosti, potvrđujući sigurnost pripremnih liječenja s tiotepom za alogene TKMS u odraslih bolesnika s hematološkim poremećajima.
English: Haematological diseases
Croatian: Hematološke bolesti
English: Live virus and bacterial vaccines must not be administered to a patient receiving an immunosuppressive chemotherapeutic agent and at least three months must elapse between discontinuation of therapy and vaccination.
Croatian: Ne treba upotrebljavati cjepiva sa živim virusima i bakterijama u bolesnika koji se liječe s imunosupresivnim kemoterapeuticima, i moraju proći najmanje tri mjeseca od prestanka terapije do cijepljenja.
English: The most frequently adverse reactions reported in the different conditioning treatments including thiotepa are: infections, cytopenia, acute GvHD and chronic GvHD, gastrointestinal disorders, haemorrhagic cystitis, mucosal inflammation.
Croatian: Najčešće nuspojave koje su prijavljene u raznim režimima pripremnih terapija s tiotepom su: infekcije, citopenija, akutne i kronične bolesti transplantata protiv domaćina (GvHD), gastrointestinalni poremećaji, hemoragijski cistitis, upala sluznice.
English: In order to prevent and manage infections, you will be given anti-infectives.
Croatian: Dobit ćete antiinfektivne lijekove za spriječavanje i liječenje infekcija.
English: When treating such patients it is recommended that serum transaminase, alkaline phosphatase and bilirubin are monitored regularly following transplant, for early detection of hepatotoxicity.
Croatian: U liječenju ovih bolesnika, za rano otkrivanje hepatotoksičnosti, preporuča se redovito praćenje serumskih transaminaza, alkalne fosfataze i bilirubina u danima nakon transplantacije.
English: Azoospermia Amenorrhoea Vaginal haemorrhage
Croatian: Azoospermija Amenoreja Vaginalno krvarenje
English: Procedures for proper handling and disposal of anticancer medicinal products must be considered.
Croatian: Moraju se slijediti postupci za pravilno rukovanje i odlaganje antitumorskih lijekova.
English: Co-administration with inhibitors of CYP2B6 (for example clopidogrel and ticlopidine) or CYP3A4 (for example azole antifungals, macrolides like erythromycin, clarithromycin, telithromycin, and protease inhibitors) may increase the plasma concentrations of thiotepa and potentially decrease the concentrations of the active metabolite TEPA.
Croatian: Istodobna primjena s inhibitorima CYP2B6 (npr. klopidogrel i tiklopidin) ili CYP3A4 (npr. antimikotik azol, makrolidi poput eritromicina, klaritromicina, telitromicina i inhibitora proteaze) može povećati plazmatsku koncentraciju tiotepe i potencijalno smanjiti koncentraciju aktivnog metabolita TEPA.
English: TEPADINA infusion solution should be inspected visually for particulate matter prior to administration.
Croatian: TEPADINA otopinu za infuziju treba vizualno pregledati prije primjene na prisustvo čestica.
English: In children, if the dose is lower than 250 mg, an appropriate volume of sodium chloride 9 mg/ml (0.9%) solution for injection may be used in order to obtain a final TEPADINA concentration between 0.5 and 1 mg/ml.
Croatian: Kod djece, ako je doza je manja od 250 mg, prikladni volumen otopine za injekcije natrijevog klorida 9 mg/ml (0,9%) se može koristiti kako bi se dobila konačna koncentracija lijeka TEPADINA između 0,5 i 1 mg/ml.
English: Both women and men using TEPADINA must use effective contraceptive methods during treatment.
Croatian: Za vrijeme terapije s lijekom TEPADINA i muškarci i žene moraju koristiti učinkovite metode kontracepcije.
English: What you need to know before you use TEPADINA 3.
Croatian: Što morate znati prije nego počnete primjenjivati lijek TEPADINA
English: Co-administration of inducers of cytochrome P450 (such as rifampicin, carbamazepine, phenobarbital) may increase the metabolism of thiotepa leading to increased plasma concentrations of the active metabolite.
Croatian: Istovremena primjena s induktorima citokroma P450 (kao što su rifampicin, karbamazepin i fenobarbiton) može ubrzati metabolizam tiotepe i tako dovesti do porasta koncentracije aktivnih metabolita u plazmi.
English: Do not use TEPADINA after the expiry date which is stated on the carton and vial label, after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i naljepnici bočice iza oznake „EXP“.
English: The adverse reactions considered at least possibly related to conditioning treatment including thiotepa, reported in paediatric patients as more than an isolated case, are listed below by system organ class and by frequency.
Croatian: Nuspojave za koje se smatra da su barem moguće povezane s pripremnom terapijom s tiotepom, prijavljene u pedijatrijskih bolesnika u više od jednog izoliranog slučaja, su navedene prema klasifikaciji organskih sustava i njihovoj učestalosti.
English: Leukoencephalopathy
Croatian: Leukoencefalopatija
English: Blood amylase increased
Croatian: Povećanje krvne amilaze
English: Eye disorders Conjunctivitis
Croatian: Poremećaji oka Konjunktivitis
English: As with other cytotoxic compounds, caution need to be exercised in handling and preparation of TEPADINA solutions to avoid accidental contact with skin or mucous membranes.
Croatian: Kao i kod drugih citotoksičnih spojeva, potreban je oprez pri rukovanju i pripremi otopina lijeka TEPADINA, kako bi se izbjegao slučajan dodir s kožom ili sluznicama.
English: Type I clear glass vial with a rubber stopper (bromobutyl or chlorobutyl), containing 15 mg thiotepa.
Croatian: Bočica od prozirnog stakla tipa I, s gumenim čepom (od bromobutila ili klorobutila), koja sadrži 15 mg tiotepe.
English: Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Učestalosti su definirane kako slijedi: vrlo česte (≥ 1/10), česte (≥1/100 i <1/10), manje česte (≥1/1000 i <1/100), rijetke (≥1/10 000 i <1/1000) vrlo rijetke (<1/10 000), nepoznato (ne može procijeniti iz dostupnih podataka).
English: Frequencies are defined as: very common (≥1/10), common ((≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Učestalosti su definirane kako slijedi: vrlo često (≥ 1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000) vrlo rijetko (<1/10 000), nepoznato (ne može procijeniti iz dostupnih podataka).
English: Accord Healthcare bvba Tèl/Tel: +32 51 79 40 12
Croatian: Luxembourg/Luxemburg Accord Healthcare bvba Tèl/Tel: +32 51 79 40 12
English: TEPADINA may have major influence on the ability to drive and use machines.
Croatian: Lijek TEPADINA mogao bi značajno utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: It is unknown whether thiotepa is excreted in human milk.
Croatian: Nije poznato izlučuje li se tiotepa u majčino mlijeko.
English: How TEPADINA is given
Croatian: Kako se daje TEPADINA
English: Overall Survival (OS): OS ranged from 50% to 100% with a follow-up ranging from 9.4 up to 121 months.
Croatian: Sveukupno preživljenje (OS - Overall Survival): OS je bilo u rasponu od 50% do 100% uz period praćenja u rasponu od 9,4 do 121 mjesec.
English: Calculation of dose of TEPADINA
Croatian: Izračunavanje doze lijeka TEPADINA
English: Posology in adults
Croatian: Tablični popis nuspojava Odrasli
English: TEPADINA is administered at different doses, in combination with other chemotherapeutic medicinal products, in patients with haematological diseases or solid tumours prior to HPCT.
Croatian: TEPADINA se daje u različitim dozama, u kombinaciji s drugim kemoterapijskim lijekovima, prije TKMS, bolesnicima s hematološkim bolestima ili sa solidnim tumorima.
English: Therefore it can be concluded that conditioning treatments including thiotepa are myeloablative.
Croatian: Stoga se može zaključiti da su pripremna liječenja s tiotepom mijeloablativna.
English: Engraftment: Conditioning treatments including thiotepa have proved to be myeloablative.
Croatian: Prihvat transplantata: Pripremna liječenja koja uključuju tiotepu su dokazano mijeloablativna.
English: Type I clear glass vial with a rubber stopper (bromobutyl or buthyl), containing 100 mg thiotepa.
Croatian: Bočica od prozirnog stakla tipa I, s gumenim čepom (od bromobutila ili butila), koja sadrži 100 mg tiotepe.
English: Idiopathic pneumonia syndrome Epistaxis
Croatian: Sindrom idiopatske pneumonije Epistaksa
English: Pigmentation disorder Erythrodermic psoriasis
Croatian: Poremećaji pigmentacije Eritrodermna psorijaza