FrancophonIA/ELRC3.0 huggingface dataset:
English: If methotrexate is administered in combination with chemotherapy regimens, the dosage should take into consideration any overlapping toxicity of the other medicinal product components.
Slovenian: Če je metotreksat uporabljen v kombinaciji s kemoterapevtskimi shemami, je treba pri odmerjanju upoštevati morebitno prekrivajočo se toksičnost drugih sestavin zdravil.
English: A 10 ml oral dosing syringe is provided for accurate measurement of the prescribed dose (see Package Leaflet).
Slovenian: Za natančno merjenje predpisanega odmerka je priložena 10-mililitrska brizga za peroralno odmerjanje (glejte navodilo za uporabo).
English: Dosage in adults with severe forms of psoriasis and adult patients with psoriatic arthritis
Slovenian: Odmerjanje pri odraslih bolnikih s hudimi oblikami psoriaze in odraslih bolnikih s psoriatičnim artritisom
English: This should also be considered during simultaneous administration of haematotoxic medicinal products.
Slovenian: To je treba upoštevati tudi, kadar bolnik sočasno prejema hematotoksična zdravila.
English: One ml of solution contains 2 mg of methotrexate.
Slovenian: 1 ml raztopine vsebuje 2 mg metotreksata.
English: − blood in the urine or stool
Slovenian: − kri v urinu ali blatu,
English: In the event of accidental overdose, a dose of calcium folinate equal to or higher than the offending dose of methotrexate should be administered intravenously or intramuscularly within 1 hour, and dosing continued until serum level of methotrexate are below 10-7 mol/L.
Slovenian: primeru nenamernega prevelikega odmerjanja mora bolnik v eni uri od prejema prevelikega odmerka metotreksata prejeti intravenski ali intramuskularni odmerek kalcijevega folinata, ki je v višini najmanj enak neustreznemu odmerku metotreksata, odmerjanje pa ponavljati, dokler se serumska koncentracija metotreksata ne zniža pod 10-7 mol/l.
English: A weekly dose of 25 mg (12.5 ml) should not be exceeded.
Slovenian: Tedenski odmerek ne sme preseči 25 mg (12,5 ml).
English: Jylamvo is a clear yellow solution.
Slovenian: Zdravilo Jylamvo je bistra rumena raztopina.
English: If combined treatment is required, the blood count and renal function should be monitored.
Slovenian: Če je potrebno zdravljenje s kombinacijo teh zdravil, je treba spremljati krvno sliko in delovanje ledvic.
English: If the lymphomas fail to regress spontaneously, cytotoxic treatment must be initiated.
Slovenian: Če limfomi ne kažejo znakov spontane regresije, je treba uvesti citotoksično zdravljenje.
English: This medicine can be taken with or without food.
Slovenian: To zdravilo lahko jemljete s hrano ali brez nje.
English: Symptoms of overdose The symptoms following oral overdose predominantly affect the haematopoietic and gastrointestinal systems.
Slovenian: Simptomi po peroralnem prevelikem odmerjanju prizadenejo predvsem hematopoetski in gastrointestinalni sistem.
English: − skin lesions resembling sunburn or dermatitis after radiotherapy
Slovenian: − sončnim opeklinam podobne kožne lezije ali dermatitis po radioterapiji,
English: − unusual bleeding (including vomiting blood), bruising or nose bleeds
Slovenian: − neobičajne krvavitve (vključno z bruhanjem krvi), pojav podplutb ali krvavitev iz nosu,
English: Pharmacotherapeutic group: Antineoplastic and immunomodulating agents, antimetabolites, folic acid analogues, ATC code: L01BA01
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe in imunomodulatorji, zaviralci celične presnove (antimetaboliti), analogi folne kisline, oznaka ATC: L01BA01
English: • Spontaneous abortions have been reported in 42.5% of pregnant women exposed to low-dose methotrexate treatment (less than 30 mg [15 ml]/week), compared to a reported rate of 22.5% in disease-matched patients treated with drugs other than methotrexate.
Slovenian: • Poročali so o spontanih splavih pri 42,5 % nosečnic, izpostavljenih zdravljenju z majhnimi odmerki metotreksata (manj kot 30 mg [15 ml] na teden), v primerjavi s poročanim deležem spontanih splavov 22,5 % pri bolnicah z istimi boleznimi, ki so bile zdravljene z drugimi zdravili kot metotreksatom.
English: Therefore, the possible effects on reproduction, pregnancy loss and congenital malformations should be discussed with female patients of childbearing age (see section 4.6).
Slovenian: Zato se je treba z bolnicami v reproduktivnem obdobju pogovoriti o možnih vplivih na reprodukcijo, izgubi ploda in kongenitalnih malformacijah (glejte poglavje 4.6).
English: Follow your doctor's dose recommendations.
Slovenian: Upoštevajte zdravnikova navodila za odmerjanje.
English: It is presented in a brown glass bottle containing 60 ml of solution and capped with a child-resistant closure.
Slovenian: Shranjeno je v rjavi steklenički, ki vsebuje 60 ml raztopine in ima za otroke varno zaporko.
English: Doses exceeding 20 mg (10 ml)/week can be associated with a substantial increase in toxicity,
Slovenian: Odmerki, ki presegajo 20 mg (10 ml)/teden, so lahko povezani s precejšnjim povečanjem toksičnosti,
English: Ethyl parahydroxybenzoate (E214) and sodium methyl parahydroxybenzoate (E219) may cause allergic reactions (possibly delayed).
Slovenian: Etilparahidroksibenzoat (E214) in natrijev metilparahidroksibenzoat (E219) lahko povzročita alergijske reakcije (ki so lahko zakasnjene).
English: - Respiratory tract examination - patients must be monitored for symptoms of a lung function disorder and lung function tests performed if necessary.
Slovenian: - Ocena delovanja dihal - treba je spremljati simptome motenj v delovanju pljuč in po potrebi izvesti preiskave delovanja pljuč.
English: When methotrexate was discontinued prior to conception, normal pregnancies have been reported.
Slovenian: V primerih prekinitve zdravljenja z metotreksatom pred zanositvijo so poročali o normalnih nosečnostih.
English: Package leaflet: Information for the user Jylamvo 2 mg/ml oral solution methotrexate
Slovenian: Navodilo za uporabo: informacije za uporabnika Jylamvo 2 mg/ml peroralna raztopina metotreksat
English: One ml of solution contains 2 mg methyl hydroxybenzoate (as the sodium salt), and 0.2 mg ethyl hydroxybenzoate.
Slovenian: 1 ml raztopine vsebuje 2 mg metilhidroksibenzoata (v obliki natrijeve soli) in 0,2 mg etilhidroksibenzoata.
English: Methotrexate can be taken with or without food.
Slovenian: Metotreksat lahko jemljete s hrano ali brez nje.
English: Contraception in males
Slovenian: Kontracepcija pri moških
English: Ensure that the patient is sitting up or standing before giving the medicine.
Slovenian: Pred dajanjem zdravila poskrbite, da bo bolnik sedel ali stal.
English: Methotrexate should be discontinued in patients with pulmonary symptoms and an immediate examination (including chest X-ray) should be performed to exclude infection and tumours.
Slovenian: - Pri bolnikih, pri katerih se pojavijo pljučni simptomi, je treba zdravljenje z metotreksatom prekiniti in takoj opraviti preiskavo (vključno z rentgenskim slikanjem prsnega koša), da se izključita možnost okužbe in prisotnost tumorjev.
English: DO NOT measure to the narrow tip of the plunger.
Slovenian: NE merite do ozke konice bata.
English: • Recommendation to always show the card to and alert new HCPs about the once weekly dosing of the patient's methotrexate (e.g. on hospital admission, change of carer, etc.)
Slovenian: • priporočilo, da bolniki pokažejo opozorilno kartico vsem novim zdravstvenim delavcem, da jih opozorijo na odmerjanje metotreksata enkrat na teden (npr. pri sprejemu v bolnišnico, spremembi skrbnika itd.).
English: Salicylates, phenylbutazone, diphenylhydantoin (= phenytoin), barbiturates, tranquillisers, oral contraceptives, tetracyclines, amidopyrine derivatives, sulphonamides, thiazide diuretics, oral hypoglycaemics, doxorubicin and p-aminobenzoic acid displace methotrexate from serum albumin binding and thus increase bioavailability and hence toxicity (indirect dose increase).
Slovenian: Salicilati, fenilbutazon, difenilhidantoin (fenitoin), barbiturati, pomirjevala, peroralni kontraceptivi, tetraciklini, aminopirinski derivati, sulfonamidi, tiazidni diuretiki, peroralna hipoglikemična zdravila, doksorubicin in p-aminobenzojska kislina izpodrivajo metotreksat s serumskega albumina ter s tem povečajo njegovo biološko uporabnost, s tem pa tudi toksičnost (posredno zvečanje odmerka).
English: All parts of the syringe should be completely dry before using it for the next dose.
Slovenian: Pred uporabo brizge za naslednji odmerek morajo biti vsi njeni deli popolnoma suhi.
English: Excretion occurs predominantly in the unchanged form by glomerular filtration and active secretion in the proximal tubule via the kidneys.
Slovenian: Izločanje Metotreksat se izloča v večinoma nespremenjeni obliki z glomerulno filtracijo in aktivno sekrecijo v proksimalnih tubulih prek ledvic.
English: Antibiotics such as penicillins, glycopeptides, sulphonamides, ciprofloxacin and cefalotin can in individual cases reduce the renal clearance of methotrexate, so that increased serum methotrexate concentrations can occur, accompanied by haematological and gastrointestinal toxicity.
Slovenian: Antibiotiki, kot so penicilini, glikopeptidi, sulfonamidi, ciprofloksacin in cefalotin, lahko v posameznih primerih zmanjšajo ledvični očistek metotreksata, kar lahko vodi do povečanih serumskih koncentracij metotreksata ter sočasne hematološke in gastrointestinalne toksičnosti.
English: Oral antibiotics such as tetracyclines, chloramphenicol and non-absorbable broad-spectrum antibiotics may reduce intestinal absorption of methotrexate or interfere with the enterohepatic circulation by inhibiting intestinal flora or suppressing bacterial metabolism.
Slovenian: Peroralni antibiotiki, kot so tetraciklini, kloramfenikol in širokospektralni antibiotiki, ki se ne absorbirajo, lahko zmanjšajo črevesno absorpcijo metotreksata ali pa z zaviranjem črevesne flore oziroma bakterijske presnove motijo enterohepatični obtok.
English: • Breast-feeding (see section 4.6)
Slovenian: • nosečnost (glejte poglavje 4.6)
English: Slowly and gently push the plunger down to gently squirt the medicine into the inside of the cheek.
Slovenian: Počasi in nežno potisnite bat navzdol, da bo zdravilo nežno brizgnilo na notranjo stran lica.
English: Opportunistic infections can occur during treatment with methotrexate, including Pneumocystis jiroveci pneumonia, which can also have a fatal outcome.
Slovenian: - Med zdravljenjem z metotreksatom se lahko pojavijo oportunistične okužbe, vključno s pljučnico, ki jo povzroča mikroorganizem Pneumocystis jiroveci in je lahko smrtna.
English: If use during the lactation period should become necessary, breast-feeding is to be stopped prior to treatment.
Slovenian: Če je uporaba metotreksata med dojenjem nujno potrebna, je treba pred začetkom zdravljenja dojenje prekiniti.
English: If women of a sexually mature age are treated, effective contraception must be used during treatment and for at least six months after.
Slovenian: V primeru zdravljenja žensk v rodni dobi je treba med zdravljenjem in še vsaj šest mesecev po njem uporabljati učinkovito kontracepcijo.
English: Keep this medicine out of the sight and reach of children, preferably in a locked cupboard.
Slovenian: Zdravilo shranjujte nedosegljivo otrokom, po možnosti v zaklenjeni omarici.
English: Hepatitis and liver failure4
Slovenian: hepatitis in jetrna odpoved4
English: What you need to know before you take Jylamvo Do not take Jylamvo
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Jylamvo
English: 75 ml amber type III glass bottle with tamper evident child-resistant closure (polypropylene with expanded polyethylene liner) containing 60 ml of oral solution.
Slovenian: Rumeno-rjava steklenička iz stekla tipa III velikosti 75 ml z za otroke varno zaporko s pečatom proti nedovoljenemu odpiranju (iz polipropilena z razširjenim vložkom iz polietilena), ki vsebuje 60 ml peroralne raztopine.
English: Particularly in the case of orthopaedic surgery where the risk of infection is high, combination therapy with methotrexate and immunomodulatory medicinal products must be used with caution.
Slovenian: Zlasti pri ortopedskih kirurških posegih, pri katerih je dovzetnost za okužbe visoka, je ob sočasni uporabi metotreksata in imunomodulirajočih zdravil potrebna posebna pozornost.
English: If you want to become pregnant, you should speak with your doctor, who may refer you for specialist advice before the planned start of treatment.
Slovenian: Če želite zanositi, se morate pred načrtovanim začetkom zdravljenja pogovoriti z zdravnikom, ki vas bo morda napotil k specialistu.
English: - Examination of the mouth and throat for mucosal changes.
Slovenian: - Pregled ustne votline in žrela glede sprememb na sluznici.
English: However, in clinical trials in which NSAIDs and salicylic acid were administered adjuvantly to patients with rheumatoid arthritis, no increase in adverse reactions was observed.
Slovenian: Vendar v kliničnih študijah, v katerih so bolniki z revmatoidnim artritisom sočasno prejemali NSAID in salicilno kislino, niso opazili povečanega tveganja za neželene učinke.
English: Conditions that cause dehydration such as vomiting, diarrhoea or stomatitis Conditions that cause dehydration such as vomiting, diarrhoea or stomatitis can increase toxicity as a result of raised active substance levels.
Slovenian: Stanja, ki povzročajo dehidracijo, kot so bruhanje, driska ali stomatitis Stanja, ki povzročajo dehidracijo, kot so bruhanje, driska ali stomatitis, lahko povečajo toksične učinke metotreksata zaradi zvišanih koncentracij zdravilne učinkovine.
English: The recommended initial dose is 7.5 mg (3.75 ml) methotrexate once weekly.
Slovenian: Priporočeni začetni odmerek je 7,5 mg (3,75 ml) metotreksata enkrat tedensko.
English: Although the clinical presentation is variable, patients with methotrexate-induced lung diseases typically suffer from fever, cough, dyspnoea or hypoxaemia.
Slovenian: Klinična slika je sicer različna, vendar imajo bolniki, oboleli za pljučnimi boleznimi, povzročenimi z metotreksatom, običajno vročino, kašljajo, težje dihajo ali pa so hipoksemični.
English: Methotrexate can affect the production of sperm, which is associated with the possibility of birth defects.
Slovenian: Metotreksat lahko vpliva na tvorbo semenske tekočine, kar je povezano z možnostjo za prirojene okvare.
English: • Severe, treatment-refractory, disabling psoriasis which does not respond sufficiently to other forms of treatment such as phototherapy, psoralen and ultraviolet A radiation (PUVA) therapy and retinoids, and severe psoriatic arthritis in adult patients.
Slovenian: • hude, na zdravljenje neodzivne psoriaze, ki povzroča invalidnost in se ne odziva ustrezno na druge oblike zdravljenja, kot so fototerapija, psoraleni in obsevanje z ultravijolično svetlobo A (PUVA) in retinoidi, ter hudega psoriatičnega artritisa pri odraslih bolnikih;
English: Combination therapy with methotrexate and leflunomide may increase the risk for pancytopenia.
Slovenian: Kombinirano zdravljenje z metotreksatom in leflunomidom lahko poveča tveganje za pojav pancitopenije.
English: PATIENT CARD TEXT
Slovenian: BESEDILO OPOZORILNE KARTICE ZA BOLNIKA
English: If you take more Jylamvo than you should
Slovenian: Če ste vzeli večji odmerek zdravila Jylamvo, kot bi smeli
English: However, as severe adverse reactions may occur even at low doses, it is essential for the treating physician to monitor patients closely (see section 4.4).
Slovenian: Ker se resni neželeni učinki pojavljajo tudi pri majhnih odmerkih, mora lečeči zdravnik bolnike natančno spremljati (glejte poglavje 4.4).
English: In humans, methotrexate has been reported to cause oligospermia, menstrual dysfunction and amenorrhoea.
Slovenian: Pri ljudeh so za metotreksat poročali, da povzroča oligospermijo, menstrualne motnje in amenorejo.
English: − blurred or restricted vision
Slovenian: − zamegljen ali poslabšan vid,
English: During concomitant therapy with methotrexate, therefore, serum theophylline levels should be monitored.
Slovenian: Zato je treba ob sočasni uporabi metotreksata nadzorovati serumske koncentracije teofilina.
English: The occurrence and severity of adverse reactions depend on dosage level and frequency of administration of methotrexate.
Slovenian: Pojavnost in stopnja resnosti neželenih učinkov sta odvisni od velikosti odmerka in pogostnosti uporabe metotreksata.
English: As methotrexate passes into breast milk and may cause toxicity in breast-fed children, treatment is contraindicated during the lactation period (see section 4.3).
Slovenian: Metotreksat prehaja v materino mleko in lahko povzroči toksične učinke pri dojenih otrocih, zato je njegova uporaba med dojenjem kontraindicirana (glejte poglavje 4.3).
English: Renal impairment and patients at risk of renal impairment As methotrexate is eliminated mainly via the kidneys, increased concentrations are to be expected in the presence of renal impairment, which may result in severe adverse reactions.
Slovenian: Okvarjeno delovanje ledvic in bolniki s tveganjem za okvarjeno delovanje ledvic Ker se metotreksat izloča predvsem skozi ledvice, lahko v primeru okvarjenega delovanja ledvic pričakujemo povišane serumske koncentracije metotreksata, kar lahko povzroči hude neželene učinke.
English: Shake the bottle.
Slovenian: Stekleničko pretresite.
English: If you had skin problems after radiotherapy (radiation dermatitis) or sunburn, these reactions can recur after methotrexate therapy (recall reaction).
Slovenian: Če ste imeli po obsevalni terapiji težave s kožo (dermatitis, povzročen z obsevanjem) ali sončne opekline, se lahko med zdravljenjem z metotreksatom te znova pojavijo (zaradi spominske reakcije).
English: In view of its possible effects on the immune system, methotrexate can falsify vaccinal and test results (immunological procedures to assess the immune reaction).
Slovenian: Metotreksat lahko zaradi svojih morebitnih učinkov na imunski sistem spremeni odziv na cepljenje in vpliva na rezultate testov (imunoloških postopkov za ugotavljanje imunskega odziva).
English: Dosage in adult patients with rheumatoid arthritis
Slovenian: Odmerjanje pri odraslih bolnikih z revmatoidnim artritisom
English: Do not use the medicine after the expiry date which is stated on the carton and label after ‘Exp'.
Slovenian: Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in nalepki poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Women who are pregnant, planning to be or breast-feeding should not handle methotrexate.
Slovenian: Nosečnice in ženske, ki načrtujejo nosečnost, ter doječe matere z metotreksatom ne smejo rokovati.
English: Accordingly, particular caution should be exercised in patients with pre-existing folic acid deficiency.
Slovenian: Posebna previdnost je potrebna pri bolnikih z že obstoječim pomanjkanjem folne kisline.
English: − infections
Slovenian: − okužbe,
English: Encephalopathy/leukoencephalopathy
Slovenian: Encefalopatija/levkoencefalopatija
English: Limited clinical evidence does not indicate an increased risk of malformations or miscarriage following paternal exposure to low-dose methotrexate (less than 30 mg [15 ml]/week).
Slovenian: Majhno število kliničnih dokazov ne kaže povečanega tveganja za malformacije ali splav po izpostavljenosti očeta majhnim odmerkom metotreksata (manj kot 30 mg [15 ml] na teden).
English: Ciclosporin may potentiate methotrexate efficacy and toxicity.
Slovenian: Ciklosporin lahko poveča učinkovitost in toksičnost metotreksata.
English: What Jylamvo looks like and contents of the pack
Slovenian: Izgled zdravila Jylamvo in vsebina pakiranja
English: The symptoms of an overdose can include bleeding, an unusual feeling of weakness, ulcers in the mouth, feeling sick, vomiting, black or bloody stools, coughing up blood or vomiting blood with a coffee grounds appearance and a reduced urine.
Slovenian: Simptomi prevelikega odmerjanja so lahko krvavitev, nenavaden občutek šibkosti, razjede v ustih, siljenje na bruhanje, bruhanje, črno ali krvavo blato, izkašljevanje krvi ali bruhanje kavni usedlini podobne krvi in manjša količina urina.
English: (include weekday of intake in full).
Slovenian: (napišite v celoti zapisan dan v tednu, ko je treba vzeti zdravilo).
English: There are reports of deaths from sepsis, septic shock, renal failure and aplastic anaemia.
Slovenian: Poročali so o smrtnih primerih zaradi sepse, septičnega šoka, ledvične odpovedi in aplastične anemije.
English: Deeside Industrial Park, Flintshire, CH5 2NS United Kingdom
Slovenian: Quay Pharmaceuticals Limited Quay House, 28 Parkway Deeside Industrial Park, Flintshire, CH5 2NS Velika Britanija
English: Excessive consumption of caffeine- or theophylline-containing beverages (coffee, caffeinated beverages, black tea) should be avoided during methotrexate therapy as the effect of methotrexate may be reduced by the possible interaction between methotrexate and methylxanthines at the adenosine receptors.
Slovenian: Med zdravljenjem z metotreksatom se je treba izogibati prekomernemu uživanju pijač, ki vsebujejo kofein ali teofilin (kave, brezalkoholnih pijač s kofeinom, črnega čaja), saj se lahko zaradi možnega medsebojnega delovanja metotreksata in metilksantinov na adenozinskih receptorjih zmanjša učinkovitost metotreksata.
English: • Detailed description regarding strength of the solution and the dose volumes to help clarify the appropriate dose of the oral solution.
Slovenian: • podrobni opis jakosti raztopine in volumnov odmerkov za ustrezno odmerjanje peroralne raztopine;
English: Concomitant therapy with medicinal products that can cause folic acid deficiency (e.g. sulphonamides, trimethoprim/sulphamethoxazole) can result in increased methotrexate toxicity.
Slovenian: Sočasna uporaba zdravil, ki povzročajo pomanjkanje folne kisline (npr. sulfonamidi, trimetoprim/sulfametoksazol), lahko poveča toksičnost metotreksata.
English: In oncologic indications, women who are planning to become pregnant are advised to consult a genetic counselling centre, if possible, prior to therapy and men should seek advice about the possibility of sperm preservation before starting therapy as methotrexate can be genotoxic at higher doses (see section 4.4).
Slovenian: Pred začetkom zdravljenja naj se vse ženske, ki želijo zanositi, posvetujejo v ambulanti za genetsko svetovanje, moški pa naj se posvetujejo o možnosti shranitve semenske tekočine, saj je metotreksat v večjih odmerkih lahko genotoksičen (glejte poglavje 4.4).
English: Your pack of Jylamvo contains a bottle of medicine with a cap, a bottle adaptor and a white dosing syringe.
Slovenian: Škatla zdravila Jylamvo vsebuje stekleničko z zdravilom, nastavek za stekleničko in belo brizgo za odmerjanje.
English: Diarrhoea and ulcerative stomatitis may be signs of toxic effects and require the discontinuation of treatment, otherwise haemorrhagic enteritis and death from intestinal perforation may occur.
Slovenian: Znaka toksičnih učinkov sta lahko driska in ulcerozni stomatitis; v tem primeru je treba zdravljenje prekiniti, sicer lahko pride do hemoragičnega enteritisa in smrti zaradi predrtja črevesa.
English: If a patient develops pulmonary symptoms, the possibility of Pneumocystis jiroveci pneumonia should be considered.
Slovenian: Če se pojavijo pljučni simptomi, je treba upoštevati možnost, da gre za pljučnico, ki jo povzroča mikroorganizem Pneumocystis jiroveci.
English: − pain, muscle weakness, changes in the sense of taste (metallic taste), inflammation of the membrane lining the brain resulting in paralysis or vomiting, pins and needles in arm and legs
Slovenian: − bolečina, mišična šibkost, spremenjeno zaznavanje okusa (kovinski okus), vnetje možganskih ovojnic, ki povzroči ohromelost ali bruhanje, mravljinčenje v rokah in nogah
English: Methotrexate should be used with caution in paediatric patients.
Slovenian: Pediatrična populacija Pri pediatričnih bolnikih je treba metotreksat uporabljati previdno.
English: In the treatment of rheumatological or dermatological diseases, Jylamvo (methotrexate) must only be taken once a week.
Slovenian: Zdravilo Jylamvo (metotreksat) za zdravljenje revmatoloških ali dermatoloških bolezni se jemlje samo enkrat na teden.