FrancophonIA/ELRC3.0 huggingface dataset:
English: Telmisartan: The pharmacokinetics of orally administered telmisartan are non-linear over doses from 20 - 160 mg with greater than proportional increases of plasma concentrations (Cmax and AUC) with increasing doses.
Slovenian: Telmisartan: Farmakokinetika peroralno apliciranega telmisartana ni linearna v razponu odmerkov od 20 do 160 mg, koncentracije v plazmi se pri rastočem odmerjanju večajo neproporcionalno (Cmax in AUC).
English: In a typical study in patients with a mean creatinine clearance of 90 ml/min the elimination half-life of hydrochlorothiazide was increased.
Slovenian: V preskušanju, ki so ga izvedli pri bolnikih s srednjo vrednostjo kreatininskega očistka 90 ml/min, je bila razpolovna doba izločanja hidroklorotiazida podaljšana.
English: PritorPlus may increase the blood pressure lowering effect of other medicines used to treat high blood pressure or of medicines with blood pressure lowering potential (e.g. baclofen, amifostine).
Slovenian: Zdravilo PritorPlus lahko poveča antihipertenzivni učinek drugih zdravil, ki znižujejo krvni tlak, ali zdravil z možnim antihipertenzivnim učinkom (npr. baklofen, amifostin).
English: Telmisartan is an orally effective and specific angiotensin II receptor subtype 1 (AT1) antagonist.
Slovenian: Telmisartan je peroralno učinkovit antagonist receptorjev angiotenzina II, podtipa 1 (AT1), s specifičnim delovanjem.
English: Gastric lesions could be prevented/ameliorated by oral saline supplementation and group housing of animals.
Slovenian: Poškodbe v želodcu so lahko preprečili ali ublažili s peroralnim dajanjem solne raztopine in s skupinsko nastanitvijo živali.
English: Investigations Rare:
Slovenian: Preiskave Redki:
English: Very rare side effects (may affect up to 1 in 10,000 people): Increased pH (disturbed acid-base balance) due to low blood chloride level.
Slovenian: Zelo redki neželeni učinki (lahko se pojavijo pri največ 1 od 10.000 bolnikov): povišan pH (porušeno ravnovesje med kislino in bazo) zaradi nizke ravni klorida v krvi.
English: Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system.
Slovenian: Na splošno se bolniki s primarnim aldosteronizmom ne odzivajo na antihipertenzive, ki delujejo z zaviranjem renin-angiotenzinskega sistema, zato zanje zdravljenja z zdravilom PritorPlus ne priporočamo.
English: Hydrochlorothiazide: Following oral administration of PritorPlus peak concentrations of hydrochlorothiazide are reached in approximately 1.0 - 3.0 hours after dosing.
Slovenian: Hidroklorotiazid: Po peroralnem dajanju zdravila PritorPlus doseže hidroklorotiazid največjo koncentracijo v plazmi približno v 1,0 do 3,0 urah.
English: Blood creatinine increased, blood creatine phosphokinase increased, hepatic enzyme increased
Slovenian: zvišana raven kreatinina v krvi, zvišana raven kreatin-fosfokinaze v krvi, zvišana raven jetrnih encimov
English: Cough and angioedema were less frequently reported in patients treated with telmisartan than in patients treated with ramipril, whereas hypotension was more frequently reported with telmisartan.
Slovenian: Pri bolnikih, ki so jemali telmisartan, so manj pogosto poročali o kašlju in angioedemu kot pri zdraviljenih z ramiprilom, medtem ko je bila hipotenzija med zdravljenjem s telmisartanom pogostejša.
English: ONTARGET (ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) compared the effects of telmisartan, ramipril and the combination of telmisartan and ramipril on cardiovascular outcomes in 25620 patients aged 55 years or older with a history of coronary artery disease, stroke, TIA, peripheral arterial disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage (e.g. retinopathy, left ventricular hypertrophy, macro- or microalbuminuria), which is a population at risk for cardiovascular events.
Slovenian: V raziskavi ONTARGET (ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) so primerjali učinke telmisartana, ramiprila in kombinacije telmisartana in ramiprila na srčnžilne izide pri 25.620 bolnikih, starih 55 let ali starejših, ki so imeli v anamnezi koronarno arterijsko bolezen, možgansko kap, prehodni ishemični napad (TIA), periferno arterijsko bolezen ali sladkorno bolezen tipa 2 z dokazano okvaro tarčnih organov (npr. retinopatijo, hipertrofijo levega prekata, makro- ali mikroalbuminurijo), torej pri populaciji s povečanim tveganjem za srčnožilne dogodke.
English: PritorPlus may be less effective in lowering the blood pressure in black patients.
Slovenian: Zdravilo PritorPlus lahko pri črni rasi manj učinkovito znižuje krvni tlak.
English: Neoplasms benign, malignant and unspecified (incl cysts and polyps) Not known:
Slovenian: sialoadenitis Benigne, maligne in neopredeljene novotvorbe (vključno s cistami in polipi) Neznana:
English: Hydrochlorothiazide may cause or exacerbate hypovolaemia which could lead to electrolyte imbalance (see section 4.4).
Slovenian: Hidroklorotiazid lahko povzroči ali poslabša hipovolemijo, kar lahko privede do neravnovesja elektrolitov (glejte poglavje 4.4).
English: The use of PritorPlus during breast feeding is not recommended.
Slovenian: Uporabe zdravila PritorPlus med dojenjem ne priporočajo.
English: The effects of fixed dose combination of telmisartan/HCTZ on mortality and cardiovascular morbidity are currently unknown.
Slovenian: Učinki fiksne kombinacije telmisartana in hidroklorotiazida na umrljivost in obolevnost zaradi srčnožilnih bolezni še niso raziskani.
English: Metabolic and endocrine effects
Slovenian: Učinki na presnovo in endokrini sistem
English: Hypokalaemia may result in muscle spasms and/or accentuate arrhythmia associated with the concomitant use of digitalis glycosides or certain antiarrhythmic medicinal products.
Slovenian: Hipokaliemija lahko povzroči mišične krče in/ali izrazitejšo aritmijo pri sočasnem jemanju digitalisovih glikozidov ali nekaterih antiaritmikov.
English: • if you have severe liver problems such as cholestasis or biliary obstruction (problems with drainage of the bile from the liver and gall bladder), or any other severe liver disease.
Slovenian: • če imate hude jetrne težave, kot sta holestaza ali zapora žolčevoda (težave z odtekanjem žolča iz jeter in žolčnika), ali katerokoli drugo hudo jetrno bolezen,
English: Medicinal products used in the treatment for gout (e.g. probenecid, sulfinpyrazone and allopurinol) Dosage adjustment of uricosuric medications may be necessary as hydrochlorothiazide may raise the level of serum uric acid.
Slovenian: Zdravila za zdravljenje protina (npr. probenecid, sulfinpirazon in alopurinol) Včasih je treba prilagoditi odmerek urikozurikov, ker lahko hidroklorotiazid poveča raven sečne kisline v serumu.
English: Precautions to be taken before handling or administering the medicinal product PritorPlus should be kept in the sealed blister due to the hygroscopic property of the tablets.
Slovenian: Previdnostni ukrepi, potrebni pred ravnanjem z zdravilom ali dajanjem zdravila Zdravilo PritorPlus je treba shranjevati v zaprtem pretisnem omotu, ker so tablete higroskopične.
English: Based on the pharmacological mechanism of action of hydrochlorothiazide its use during the second and third trimester may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterus, disturbance of electrolyte balance and thrombocytopenia.
Slovenian: Na osnovi farmakološkega mehanizma delovanja hidroklorotiazida lahko njegova uporaba v drugem in tretjem trimesečju nosečnosti ogroža fetoplacentno perfuzijo in lahko pri plodu ali novorojenčku povzroči zlatenico, motnje elektrolitskega ravnovesja in trombocitopenijo.
English: PritorPlus should not be given to patients with cholestasis, biliary obstructive disorders or severe hepatic insufficiency (see section 4.3) since telmisartan is mostly eliminated with the bile.
Slovenian: Zdravila PritorPlus ne smemo dajati bolnikom s holestazo, z obolenji z zaporo žolčevoda ali močno zmanjšanim delovanjem jeter (glejte poglavje 4.3), ker se telmisartan v glavnem izloča z žolčem.
English: PritorPlus tablets are for once-daily oral administration and should be taken with liquid, with or without food.
Slovenian: Jemanje tablet PritorPlus je peroralno enkrat na dan s tekočino, s hrano ali brez nje.
English: There was no evidence for benefit on cardiovascular mortality (hazard ratio 1.03, 95 % CI 0.85 - 1.24).
Slovenian: Za srčnožilno umrljivost koristnost tega zdravljenja ni bila dokazana (razmerje ogroženosti 1,03, 95-odstotni IZ 0,85 do 1,24).
English: Angiotensin-II is a substance produced in your body which causes your blood vessels to narrow, thus increasing your blood pressure.
Slovenian: Angiotenzin II je snov, ki nastaja v telesu in povzroča, da se krvne žile zožijo, kar zviša krvni tlak.
English: Management depends on the time since ingestion and the severity of the symptoms.
Slovenian: Ukrepamo glede na čas, ki je pretekel od zaužitja prevelikega odmerka in resnost simptomov.
English: Thiazides in high doses causing intense diuresis can inhibit the milk production.
Slovenian: Veliki odmerki tiazidov povzročajo pospešeno diurezo in lahko zavrejo nastajanje mleka.
English: If any of the above applies to you, tell your doctor or pharmacist before taking PritorPlus.
Slovenian: Če imate katero od naštetih stanj, povejte zdravniku ali farmacevtu preden boste vzeli zdravilo PritorPlus.
English: Dose-relationship of adverse reactions was not established and they showed no correlation with gender, age or race of the patients.
Slovenian: Med neželenimi učinki in spolom, starostjo ali raso bolnikov ni bilo korelacije.
English: Thiazide therapy may impair glucose tolerance, whereas hypoglycaemia may occur in diabetic patients under insulin or antidiabetic therapy and telmisartan treatment.
Slovenian: Zdravljenje s tiazidi lahko poslabša toleranco za glukozo, medtem ko se lahko pri bolnikih s sladkorno boleznijo, ki se zdravijo z insulinom ali peroralnimi antidiabetiki in telmisartanom, pojavi hipoglikemija.
English: Therefore the use of a combination of telmisartan and ramipril is not recommended in this population.
Slovenian: Iz tega sledi, da pri opisani populaciji uporaba kombinacije telmisartana in ramiprila ni priporočena.
English: Read the package leaflet for further information.
Slovenian: Za nadaljnje informacije glejte navodilo za uporabo.
English: The risk of hypokalaemia is greater in patients with cirrhosis of liver, in patients experiencing brisk diuresis, in patients who are receiving inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or Adrenocorticotropic hormone (ACTH) (see section 4.5).
Slovenian: Možnost, da se bo hipokaliemija pojavila, je večja pri bolnikih z jetrno cirozo, s povečano diurezo ali pri bolnikih, ki peroralno ne dobivajo ustreznih odmerkov elektrolitov, in pri sočasnem zdravljenju s kortikosteroidi ali adrenokortikotropnim hormonom (ACTH) (glejte poglavje 4.5).
English: MARKETING AUTHORISATION NUMBER(S) EU/1/02/215/015-021
Slovenian: EU/1/02/215/015-021
English: Anticholinergic agents (e.g. atropine, biperiden) may increase the bioavailability of thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate.
Slovenian: Antiholinergiki (npr. atropin, biperiden) lahko povečajo biološko uporabnost tiazidnih diuretikov, ker zmanjšajo motiliteto prebavil in upočasnijo praznjenje želodca.
English: Due to the hydrochlorothiazide component, markedly low blood pressure and low blood levels of potassium can also happen, which may result in nausea, sleepiness and muscle cramps and/or irregular heartbeat associated with the concomitant use of drugs such as digitalis or certain anti-arrhythmic treatments.
Slovenian: Zaradi hidroklorotiazida v zdravilu se lahko znatno znižata krvni tlak in raven kalija v krvi, kar lahko povzroči siljenje na bruhanje, zaspanost in mišične krče in/ali neenakomerno bitje srca v povezavi s sočasno uporabo zdravil, na primer digitalisa ali nekaterih zdravil za zdravljenje aritmije.
English: Cases of photosensitivity reactions have been reported with thiazide diuretics (see section 4.8).
Slovenian: Za tiazidne diuretike so poročali o primerih fotosenzibilnih reakcij (glejte poglavje 4.8).
English: Metformin should be used with precaution: risk of lactic acidosis induced by a possible functional renal failure linked to hydrochlorothiazide.
Slovenian: Moramo ga dajati previdno zaradi nevarnosti laktatne acidoze, ki jo povzroči funkcionalna motnja delovanja ledvic, povezana s hidroklorotiazidom.
English: LIST OF EXCIPIENTS Contains lactose monohydrate and sorbitol (E420).
Slovenian: SEZNAM POMOŽNIH SNOVI Vsebuje laktozo monohidrat in sorbitol (E420).
English: The active substances are telmisartan and hydrochlorothiazide.
Slovenian: Učinkovini sta telmisartan in hidroklorotiazid.
English: Thiazides may increase the risk of adverse effects caused by amantadine.
Slovenian: Tiazidi lahko povečajo nevarnost neželenih učinkov amantadina.
English: The most commonly reported adverse reaction is dizziness.
Slovenian: Najpogostnejši neželeni učinek je bila omotica.
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (including hypokalaemia, hyponatraemia and hypochloraemic alkalosis).
Slovenian: Tiazidi, tudi hidroklorotiazid, lahko povzročijo motnje ravnovesja tekočin ali elektrolitov (tudi hipokaliemijo, hiponatriemijo in hipokloremično alkalozo).
English: Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnesaemia (see section 4.5).
Slovenian: Pokazalo se je, da tiazidi povečajo izločanje magnezija s sečem, kar lahko povzroči hipomagneziemijo (glejte poglavje 4.5).
English: Thiazides may reduce the renal excretion of cytotoxic medicinal products and potentiate their myelosuppressive effects.
Slovenian: Tiazidi lahko zmanjšajo izločanje citotoksičnih zdravil skozi ledvica in povečajo njihove mielosupresivne učinke.
English: Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloraemia) and hypovolaemia resulting from excessive diuresis.
Slovenian: Prevelik odmerek hidroklorotiazida povzroči izgubo elektrolitov (hipokaliemija, hipokloremija) in hipovolemijo zaradi prevelike diureze.
English: Based on modest experience in patients with mild to moderate renal impairment (creatinine clearance of 30 - 60 ml/min, mean about 50 ml/min) no dosage adjustment is necessary in patients with decreased renal function.
Slovenian: Redke izkušnje pri bolnikih z blago do zmerno ledvično okvaro (s kreatininskim očistkom 30 do 60 ml/min in srednjo vrednostjo približno 50 ml/min) kažejo, da bolnikom z zmanjšanim delovanjem ledvic odmerka ni treba prilagajati.
English: Conversely, due to the antagonism of the angiotensin II (AT1) receptors by the telmisartan component of PritorPlus, hyperkalaemia might occur.
Slovenian: Zaradi antagonističnega delovanja telmisartana v zdravilu PritorPlus na receptorje za angiotenzin II (AT1) je možna tudi hiperkaliemija.
English: In patients with impaired renal function the rate of hydrochlorothiazide elimination is reduced.
Slovenian: Pri bolnikih z zmanjšanim delovanjem ledvic se hidroklorotiazid počasneje izloča.
English: The most prominent manifestations of telmisartan overdose were hypotension and tachycardia; bradycardia, dizziness, vomiting, increase in serum creatinine, and acute renal failure have also been reported.
Slovenian: Najizrazitejša učinka po prevelikem odmerku telmisartana sta hipotenzija in tahikardija; poročila navajajo še bradikardijo, vrtoglavico, bruhanje, povečanje ravni kreatinina v serumu in akutno ledvično odpoved.
English: Telmisartan was found to be similarly effective to ramipril in the pre-specified secondary endpoint of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke [0.99 (97.5 % CI 0.901.08), p (non-inferiority) = 0.0004], the primary endpoint in the reference study HOPE (The Heart Outcomes Prevention Evaluation Study), which had investigated the effect of ramipril vs. placebo.
Slovenian: Telmisartan je učinkoval podobno kot ramipril na vnaprej opredeljeni sekundarni opazovani dogodek, ki je zajemal srčnožilno smrt, neusodni miokardni infarkt in neusodno možgansko kap [0,99 (97,5odstotni IZ 0,90 do 1,08), p (enakovrednost) = 0,0004], in je bil primarni opazovani dogodek v referenčni raziskavi HOPE (The Heart Outcome Prevention Evaluation Study), v kateri so ramipril primerjali s placebom.
English: TRANSCEND randomized ACE-I intolerant patients with otherwise similar inclusion criteria as ONTARGET to telmisartan 80 mg (n=2954) or placebo (n=2972), both given on top of standard care.
Slovenian: V raziskavi TRANSCEND so bolnike, ki ne prenašajo zaviralcev ACE, na podlagi vključitvenih meril, ki so bila podobna kot v raziskavi ONTARGET, naključno razvrstili v dve skupini: s telmisartanom po 80 mg (n = 2954) ali placebom (n = 2972), ki so ju jemali dodatno ob standardni zdravstveni oskrbi.
English: Concomitant administration of hydrochlorothiazide and telmisartan does not appear to affect the pharmacokinetics of either substance in healthy subjects.
Slovenian: Kaže, da sočasno dajanje hidroklorotiazida in telmisartana pri zdravih osebah ne spremeni farmakokinetike ene ali druge učinkovine.
English: Try to take a tablet at the same time each day.
Slovenian: Priporočeni odmerek je ena tableta na dan. Poskusite tablete jemati vsak dan ob isti uri.
English: Xanthopsia, acute myopia, acute angle-closure glaucoma
Slovenian: ksantopsija, akutna miopija, akutni glavkom zaprtega zakotja
English: As with other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or obstructive hypertrophic cardiomyopathy.
Slovenian: Enako kot za uporabo drugih vazodilatatorjev velja posebna previdnost pri dajanju zdravila PritorPlus bolnikom z zožitvijo aorte ali mitralne zaklopke ali obstruktivno hipertrofično kardiomiopatijo.
English: • Refractory hypokalaemia, hypercalcaemia.
Slovenian: • refraktarna hipokaliemija, hiperkalciemija.
English: Telmisartan: Following oral administration peak concentrations of telmisartan are reached in 0.5 - 1.5 h after dosing.
Slovenian: Telmisartan: Telmisartan doseže po peroralnem dajanju največjo koncentracijo v 0,5 do 1,5 ure.
English: Medicinal products associated with potassium loss and hypokalaemia (e.g. other kaliuretic diuretics, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G sodium, salicylic acid and derivatives)
Slovenian: Zdravila, ki povzročajo izgubo kalija in hipokaliemijo (npr. drugi kaliuretični diuretiki, laksativi, kortikosteroidi, ACTH, amfotericin, karbenoksolon, natrijev benzilpenicilinat, salicilna kislina in derivati)
English: Anaphylactic reactions, hypersensitivity
Slovenian: anafilaktične reakcije, preobčutljivost
English: Patients were randomized to one of the three following treatment groups: telmisartan 80 mg (n = 8542), ramipril 10 mg (n = 8576), or the combination of telmisartan 80 mg plus ramipril 10 mg (n = 8502), and followed for a mean observation time of 4.5 years.
Slovenian: Bolnike so naključno razvrstili v tri skupine, ki so prejemale telmisartan po 80 mg (n = 8542), ramipril po 10 mg (n = 8576) ali kombinacijo telmisartana po 80 mg in ramiprila po 10 mg (n = 8502).
English: Antidiabetic medicinal products (oral agents and insulin)
Slovenian: Antidiabetiki (peroralni antidiabetiki in insulin)
English: Nondepolarizing skeletal muscle relaxants (e.g. tubocurarine) The effect of nondepolarizing skeletal muscle relaxants may be potentiated by hydrochlorothiazide.
Slovenian: Nedepolarizirajoči mišični relaksanti s perifernim delovanjem (npr. tubokurarin) Hidroklorotiazid lahko poveča učinek nedepolarizirajočih relaksantov skeletnih mišic.
English: 3: For further description, please see sub-section “Description of selected adverse reactions” Hydrochlorothiazide:
Slovenian: 3: Za podrobnejši opis glejte podpoglavje »Opis izbranih neželenih učinkov« Hidroklorotiazid
English: After a single dose of
Slovenian: Po enkratnem odmerku s
English: These patients can be expected to have reduced hepatic clearance for telmisartan.
Slovenian: Pri njih lahko pričakujemo zmanjšan jetrni očistek telmisartana.
English: In some patients with compromised renal function (e.g. dehydrated patients or elderly patients with compromised renal function) the co-administration of angiotensin II receptor antagonists and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Slovenian: Pri nekaterih bolnikih z zmanjšanim delovanjem ledvic (na primer pri dehidriranih ali starejših z zmanjšanim delovanjem ledvic) lahko sočasno dajanje antagonistov receptorjev angiotenzina II in zdravil, ki zavirajo ciklooksigenazo, povzroči nadaljnje poslabšanje delovanja ledvic, tudi akutno ledvično odpoved, ki je običajno reverzibilna.
English: This medicinal product contains lactose monohydrate and sorbitol.
Slovenian: To zdravilo vsebuje laktozo monohidrat in sorbitol.
English: Toxicological findings also well known from preclinical studies with angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists were: a reduction of red cell parameters (erythrocytes, haemoglobin, haematocrit), changes of renal haemodynamics (increased blood urea nitrogen and creatinine), increased plasma renin activity, hypertrophy/hyperplasia of the juxtaglomerular cells and gastric mucosal injury.
Slovenian: Toksikološki izvidi, ki so znani tudi iz predkliničnih raziskav o zaviralcih angiotenzinske konvertaze in antagonistih angiotenzina II, so bili: zmanjšanje parametrov rdečih krvničk (eritrocitov, hemoglobina, hematokrita); spremembe ledvične hemodinamike (povečana vsebnost dušika v sečnini v krvi in kreatinina); povečana aktivnost renina v plazmi; hipertrofija oz. hiperplazija jukstaglomerulnih celic in poškodba želodčne sluznice.
English: Telmisartan showed a similar effect to ramipril in reducing the primary composite endpoint of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for congestive heart failure.
Slovenian: Telmisartan je podobno učinkovito kot ramipril zmanjšal primarni, sestavljeni opazovani dogodek, ki je zajemal srčnožilno smrt, neusodni miokardni infarkt, neusodno možgansko kap ali bolnišnično zdravljenje zaradi kongestivnega srčnega popuščanja.
English: If your liver is not working properly, the usual dose should not exceed 40 mg/12.5 mg once a day.
Slovenian: Če imate motnje delovanja jeter, običajni odmerek ne sme prekoračiti 40 mg/12,5 mg enkrat na dan.
English: The effect of pressor amines may be decreased.
Slovenian: Njihov učinek se lahko zmanjša.
English: This is confirmed by measurements made at the point of maximum effect and immediately prior to the next dose (through to peak ratios consistently above 80 % after doses of 40 and 80 mg of telmisartan in placebo controlled clinical studies).
Slovenian: Enakomerno trajanje učinka so potrdile meritve pri največjem učinku in tik pred naslednjim odmerkom (v s placebom nadzorovanih kliničnih preskušanjih je bil količnik med pojemanjem učinka in največjim učinkom vedno nad 80 %).
English: If PritorPlus is used during breast feeding, doses should be kept as low as possible.
Slovenian: Če doječe matere zdravilo PritorPlus uporabljajo med dojenjem, morajo biti njegovi odmerki karseda majhni.