FrancophonIA/ELRC3.0 huggingface dataset:
English: Activate the safety guard over the needle, in one of the two methods shown: - either press the hinged section of the safety guard down onto a hard surface (figure A), - or push the hinge forward with your finger
Slovenian: Aktivirajte varnostni ščitnik, da pokrije iglo, in sicer na enega od dveh prikazanih načinov: - bodisi pritisnite zglob varnostnega ščitnika navzdol ob trdo površino (slika A), - ali pa zglob potisnite naprej s prstom
English: Within each frequency grouping, adverse reactions are presented in the order of decreasing seriousness.
Slovenian: V vsaki pogostnostni skupini so neželeni učinki navedeni po padajoči resnosti.
English: Health-related quality of life was assessed by a disease-specific patient-reported outcome measure (CushingQoL) and a generic quality of life measure (SF-12v2 General Health Survey).
Slovenian: Kakovost življenja v povezavi z zdravjem so ocenjevali s pomočjo za bolezen specifičnih meril o izidih bolezni, ki jih poročajo bolniki (vprašalnik CushingQoL) in meril za splošno kakovost življenja (splošni vprašalnik o zdravju SF-12v2).
English: Hold the base of the ampoule in one hand.
Slovenian: Z eno roko držite spodnji del ampule.
English: Injection site reactions were reported in 13.6% of patients enrolled in the phase III study in Cushing's disease.
Slovenian: O reakcijah na mestu injiciranja so poročali pri 13,6 % bolnikov, ki so bili vključeni v študijo faze III pri bolnikih s Cushingovo boleznijo.
English: FOR DEEP INTRAMUSCULAR INJECTION ONLY.
Slovenian: SAMO ZA GLOBOKO INTRAMUSKULARNO INJICIRANJE.
English: Recommended procedure: hold the ampoule in an upright position with the coloured dot facing away from you.
Slovenian: Priporočen postopek: ampulo držite v pokončnem položaju tako, da je obarvana pika obrnjena stran od vas.
English: In patients who developed hyperglycaemia, the condition generally appeared to respond to antidiabetic therapy.
Slovenian: Pri bolnikih, pri katerih se je razvila hiperglikemija, se je le-ta običajno odzvala na zdravljenje z antidiabetiki.
English: Your doctor may want to monitor your blood sugar and start treatment with or adjust your antidiabetic medicine.
Slovenian: Zdravnik bo morda hotel spremljati vrednosti sladkorja v krvi in vam uvesti zdravljenje s katerim od zdravil za zniževanje krvnega sladkorja oziroma prilagoditi njegovo odmerjanje.
English: The overall incidence of hyperglycaemia-related adverse reactions was 75.3% (all grades) and 22.7% (CTC Grade 3).
Slovenian: Skupna pogostnost vseh s hiperglikemijo povezanih neželenih učinkov je bila 75,3 % (za vse stopnje) oziroma 22,7 % (za stopnjo 3 po kriterijih CTC).
English: Monitoring of liver function is recommended prior to treatment with pasireotide intramuscular use and after the first two to three weeks, then monthly for three months on treatment.
Slovenian: Jetrno funkcijo je priporočeno spremljati pred začetkom zdravljenja s pasireotidom za intramuskularno uporabo in po prvih dveh do treh tednih, nato pa tri mesece enkrat na mesec.
English: This medicinal product contains less than 1 mmol (23 mg) sodium per dose, i.e. it is essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni, da je “brez natrija”.
English: Monitoring for an effect on the QTc interval is advisable 21 days after the beginning of the treatment and as clinically indicated thereafter.
Slovenian: Vpliv na interval QTc je priporočeno preveriti 21 dni po začetku zdravljenja in kasneje, kadar je klinično indicirano.
English: Nearly half of the patients had additional prior medical treatment for acromegaly other than somatostatin analogues.
Slovenian: Približno polovica teh bolnikov je predhodno zaradi akromegalije poleg analogov somatostatina prejemala tudi druga zdravila.
English: The maximum recommended dose for these patients is 0.6 mg twice a day.
Slovenian: Najvišji priporočeni odmerek za te bolnike je 0,6 mg dvakrat na dan.
English: Grade 3 adverse reactions were observed in 35.8% of patients and Grade 4 adverse reactions in 2.5% of patients.
Slovenian: Neželene učinke 3. stopnje so opažali pri 35,8 % bolnikov in neželene učinke 4. stopnje pri 2,5 % bolnikov.
English: Breast-feeding should be discontinued during treatment with Signifor.
Slovenian: Med zdravljenjem z zdravilom Signifor je treba prenehati z dojenjem.
English: Concomitant administration of pasireotide and ciclosporin may require adjustment of the ciclosporin dose to maintain therapeutic levels.
Slovenian: Pri sočasni uporabi pasireotida in ciklosporina je v nekaterih primerih treba prilagoditi odmerek ciklosporina za vzdrževanje njegove terapevtske ravni.
English: Embryo toxicity was seen in rats and rabbits at doses that caused maternal toxicity but no teratogenic potential was detected.
Slovenian: Pri podganah in kuncih so pri odmerkih, ki so bili toksični za mater, opažali toksično delovanje na zarodek, teratogenega potenciala pa niso odkrili.
English: Gently tap the syringe to remove any visible bubbles and expel them from the syringe.
Slovenian: Nežno potrkajte po brizgi, da odstranite morebitne vidne zračne mehurčke in jih iztisnite iz brizge.
English: A total of 198 patients were randomised to receive pasireotide intramuscular use 40 mg (n=65), pasireotide intramuscular use 60 mg (n=65) or active control (n=68).
Slovenian: Skupno so 198 bolnikov randomizirali tako, da so prejemali pasireotid za intramuskularno uporabo v odmerku 40 mg (n=65), pasireotid za intramuskularno uporabo v odmerku 60 mg (n=65) ali primerjalno zdravilo (n=68).
English: There are two critical steps in the reconstitution of Signifor.
Slovenian: Rekonstitucija zdravila Signifor vključuje dva kritična koraka.
English: The adverse reactions in Table 1 include events reported in the pivotal studies with the intramuscular formulation in patients with acromegaly and with Cushing's disease.
Slovenian: Neželeni učinki v preglednici 1 vključujejo dogodke, o katerih so poročali v ključnih študijah oblike za intramuskularno dajanje pri bolnikih z akromegalijo in tistih s Cushingovo boleznijo.
English: Adverse reactions are listed according to MedDRA primary system organ class.
Slovenian: Neželeni učinki so navedeni po organskih sistemih v skladu s klasifikacijo MedDRA.
English: ATTENTION: Keep the plunger pressed and shake the vial moderately for a minimum of 30 seconds so that the powder is completely suspended.
Slovenian: OPOZORILO: Bat držite pritisnjen do konca in zmerno stresajte vialo najmanj 30 sekund, tako da se prašek v celoti zmeša z vehiklom.
English: Table 1 Adverse reactions by preferred term for pasireotide intramuscular use
Slovenian: Preglednica 1 Neželeni učinki pasireotida za intramuskularno uporabo po prednostnih izrazih
English: Let the kit stand at room temperature for a minimum of 30 minutes before reconstitution, but do not exceed 24 hours.
Slovenian: Komplet naj pred rekonstitucijo stoji na sobni temperaturi najmanj 30 minut, vendar ne več kot 24 ur.
English: Signifor suspension must only be prepared immediately before administration.
Slovenian: Suspenzijo zdravila Signifor je treba pripraviti šele tik pred dajanjem.
English: Due to its broad binding profile to somatostatin receptors, pasireotide has the potential to stimulate both hsst2 and hsst5 subtype receptors relevant for inhibition of GH and IGF-1 secretion and therefore to be effective for the treatment of acromegaly.
Slovenian: Zaradi širokega profila vezave na receptorje za somatostatin lahko pasireotid stimulira tako receptorje podvrste hsst2 kot podvrste hsst5, ki so pomembni za zaviranje sproščanja rastnega hormona in faktorja IGF-1, zato je pasireotid lahko učinkovit pri zdravljenju akromegalije.
English: Store Signifor ampoules according to the storage conditions listed on the box.
Slovenian: Ampule z zdravilom Signifor shranjujte v skladu z navodili, ki so navedena na škatli.
English: Preferred injection sites for subcutaneous injections are the top of the thighs and the abdomen (excluding the navel or waistline).
Slovenian: Najprimernejša mesta za subkutano injiciranje so zgornji del stegen in trebuh (razen popka in predela pasu).
English: Hold the syringe in one hand between two fingers with your thumb at the bottom of the plunger.
Slovenian: Z eno roko primite brizgo tako, da jo držite med dvema prstoma, palec pa nastavite na vrh bata.
English: IGF-1 mean values at baseline were 2.6, 2.8 and 2.9 x ULN, respectively.
Slovenian: Povprečne izhodiščne koncentracije faktorja IGF-1 so bile 2,6, 2,8 oziroma 2,9 x ZMN.
English: You should also avoid injections at sites that are sore or where the skin is irritated.
Slovenian: Poleg tega pazite, da si zdravila ne injicirate na mestih, kjer je koža boleča ali vneta.
English: Grade 3 and 4 adverse reactions were mostly related to hyperglycaemia.
Slovenian: Neželeni učinki 3. in 4. stopnje so bili večinoma povezani s hiperglikemijo.
English: Important information about some of the ingredients of Signifor Signifor contains less than 1 mmol sodium (23 mg) per dose, which means it is essentially “sodium-free”.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila Signifor Zdravilo Signifor vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni, da je “brez natrija”.
English: Further decrease in tumour volume was observed at month 12 after crossover for both treatment groups, and was higher in patients who crossed over to pasireotide intramuscular use (-24.7%) than in patients who crossed over to octreotide intramuscular use (-17.9%).
Slovenian: V obeh študijskih skupinah so 12 mesecev po navzkrižni zamenjavi zdravila opažali nadaljnje zmanjšanje tumorske mase, ki je bilo večje pri bolnikih, ki so prešli na intramuskularno uporabo pasireotida (-24,7 %), kot pri bolnikih, ki so prešli na intramuskularno uporabo oktreotida (-17,9 %).
English: The eligibility criteria included a mean urinary free cortisol (mUFC) value of between 1.5 and 5 times upper limit of normal (ULN) at screening.
Slovenian: Med kriteriji primernosti za vključitev je bila povprečna vrednost prostega kortizola v urinu (angl. mean urinary free cortisol, mUFC) med 1,5-kratnikom in 5-kratnikom zgornje meje normalnih vrednosti (ZMN) ob presejanju.
English: Do not inject a double dose of Signifor to make up for a forgotten dose.
Slovenian: Ne injicirajte si dvojnega odmerka zdravila Signifor, če ste pozabili vzeti prejšnji odmerek.
English: Decreases were also demonstrated by the overall percentage of change in mean and median UFC levels at month 6 and 12 as compared to baseline values (see Table 3).
Slovenian: Znižanja so se pokazala tudi pri skupni odstotni spremembi povprečnih in medianih vrednosti UFC po 6 in 12 mesecih v primerjavi z izhodiščnimi vrednostmi (glejte preglednico 3).
English: The safety profile of pasireotide intramuscular use was largely similar between the acromegaly and Cushing's disease indications.
Slovenian: Varnostni profil pasireotida za intramuskularno uporabo je bil večinoma podoben pri obeh indikacijah, torej pri akromegaliji in Cushingovi bolezni.
English: Each ampoule contains 1 ml of solution for injection.
Slovenian: Ena ampula vsebuje 1 ml raztopine za injiciranje.
English: In the pivotal study with patients who did not receive prior medical treatment, the proportion of patients who required commencement of anti-diabetic therapy during the study was 36% in the Signifor arm compared to 4.4% in the active control arm.
Slovenian: V ključni študiji z bolniki, ki pred tem še niso bili zdravljeni, je delež bolnikov, ki so se morali začeti zdraviti z antidiabetiki v času študije, znašal 36 % v skupini z zdravilom Signifor v primerjavi s 4,4 % v skupini s primerjalnim zdravilom.
English: Pull the protective cover straight off the needle.
Slovenian: Zaščitni pokrovček potegnite z igle povsem naravnost.
English: This means that it is injected through a needle into the muscles of your buttocks.
Slovenian: To pomeni, da vam ga bodo z iglo injicirali v mišico na zadnjici.
English: The human body naturally produces a substance called somatostatin, which blocks the production of certain hormones, including ACTH.
Slovenian: V človeškem telesu normalno nastaja snov, ki jo imenujemo somatostatin in zavira tvorbo določenih hormonov, med drugim tudi hormona ACTH.
English: Careful monitoring is recommended in patients with cardiac disease and/or risk factors for bradycardia, such as history of clinically significant bradycardia or acute myocardial infarction, high-grade heart block, congestive heart failure (NYHA Class III or IV), unstable angina, sustained ventricular tachycardia, ventricular fibrillation.
Slovenian: Skrbno spremljanje je priporočeno pri bolnikih z boleznimi srca in/ali z dejavniki tveganja za bradikardijo, kot so klinično pomembna bradikardija ali akutni miokardni infarkt v anamnezi, srčni blok visoke stopnje, kongestivno popuščanje srca (funkcijski razred NYHA III ali IV), nestabilna angina pektoris, obstojna ventrikularna tahikardija in ventrikularna fibrilacija.
English: Pasireotide is metabolically highly stable and in vitro data show that pasireotide is not a substrate, inhibitor or inducer of any major enzymes of CYP450.
Slovenian: Pasireotid je metabolično zelo stabilen in podatki raziskav in vitro kažejo, da ni substrat, zaviralec ali induktor nobenega od pomembnejših encimov CYP450.
English: How to inject Signifor
Slovenian: Kako injicirati zdravilo Signifor
English: Use syringes and needles only once.
Slovenian: Vsako brizgo ali iglo lahko uporabite samo enkrat.
English: The recommended initial dose is 0.6 mg pasireotide by subcutaneous injection twice a day.
Slovenian: Priporočeni začetni odmerek je 0,6 mg pasireotida s subkutano injekcijo dvakrat na dan.
English: The study met its primary efficacy endpoint for both pasireotide intramuscular use doses.
Slovenian: Primarni cilj opazovanja glede učinkovitosti je bil dosežen pri obeh odmerkih pasireotida za intramuskularno uporabo.
English: Decreases were also demonstrated by the overall percentage change from baseline in mean and median mUFC levels at month 7 and 12.
Slovenian: Znižanja so se pokazala tudi pri skupni odstotni spremembi glede na izhodišče v povprečnih in medianih vrednostih mUFC po 7 in 12 mesecih.
English: The coloured dot on the top part marks the position of the breaking point on the neck of the ampoule.
Slovenian: Obarvana pika na vrhnjem delu označuje mesto lomilne zareze na vratu ampule.
English: Most patients (82.0%) had undergone prior pituitary surgery, and the mean baseline mUFC was 470 nmol/24h (ULN: 166.5 nmol/24h).
Slovenian: Večina bolnikov (82,0 %) je že prestala operacijo hipofize, njihova povprečna izhodiščna vrednost mUFC pa je bila 470 nmol/24 h (ZMN: 166,5 nmol/24 h).
English: Dispose of the used syringe and needle immediately in a sharps container or other rigid closed disposal container.
Slovenian: Uporabljeno brizgo in iglo takoj zavrzite v vsebnik za ostre predmete ali drug trden zabojnik za odpadke z dobrim zapiranjem.
English: After four months of treatment, patients with mUFC ≤1.5xULN continued on the blinded dose to which they were randomised, and patients with mUFC >1.5xULN had their doses increased in a blinded manner from 10 mg to 30 mg, or from 30 mg to 40 mg, provided there were no tolerability concerns.
Slovenian: Po štirih mesecih zdravljenja so bolniki z vrednostjo mUFC ≤ 1,5 x ZMN nadaljevali slepo zdravljenje z odmerkom, ki so jim ga določili pri randomizaciji, bolnikom z vrednostjo mUFC > 1,5 x ZMN pa so odmerke zvišali na slep način z 10 mg na 30 mg oziroma s 30 mg na 40 mg, če niso imeli težav s prenašanjem odmerka.
English: Mean fasting plasma glucose levels commonly increased within the first month of treatment, with decreases and stabilisation observed in subsequent months.
Slovenian: Povprečne vrednosti glukoze v plazmi na tešče so se v prvem mesecu zdravljenja pogosto zvišale, v naslednjih mesecih pa so opažali njihovo znižanje in stabilizacijo.
English: During the extension phase, tumour volume continued to decrease.
Slovenian: V fazi podaljšanja se je pri bolnikih tumorska masa še naprej zmanjševala.
English: Signifor is thus able to block the production of ACTH, helping to control the over-production of cortisol and improve the symptoms of Cushing's disease.
Slovenian: Zdravilo Signifor tako lahko zavre tvorbo hormona ACTH, kar pomaga uravnavati prekomerno nastajanje kortizola in izboljša simptome Cushingove bolezni.
English: Signifor is a medicine that contains the active substance pasireotide.
Slovenian: Signifor je zdravilo, ki vsebuje zdravilno učinkovino pasireotid.
English: Make sure there is no air bubble in the syringe by pressing the plunger until the first drop appears on the tip of the needle.
Slovenian: Poskrbite, da v brizgi ne bo zračnih mehurčkov: na bat pritisnite samo toliko, da se na vrhu igle pojavi kapljica.
English: Not following them could result in failure to deliver the injection appropriately.
Slovenian: Če ju ne izvedete pravilno, se lahko zgodi, da zdravila z injiciranjem ne boste odmerili pravilno.
English: A supportive efficacy analysis was conducted in which patients were further classified into 3 response categories regardless of up-titration at month 3: Fully controlled (UFC ≤1.0 x ULN), partially controlled (UFC >1.0 x ULN but with a reduction in UFC ≥50% compared to baseline) or uncontrolled (reduction in UFC <50%).
Slovenian: V podporo tej analizi so izvedli dodatno analizo učinkovitosti, za katero so bolnike nadalje razdelili v 3 kategorije odziva ne glede na zviševanje odmerka po 3 mesecih: povsem urejeni bolniki (z vrednostjo UFC ≤1,0 x ZMN), deloma urejeni bolniki (z vrednostjo UFC >1,0 x ZMN, a z znižanjem vrednosti UFC za ≥50 % v primerjavi z izhodiščno vrednostjo) in neurejeni bolniki (z znižanjem vrednosti UFC za <50 %).
English: Non-clinical safety data from studies performed with pasireotide administered via the subcutaneous route reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity and carcinogenic potential.
Slovenian: Predklinični podatki o varnosti iz študij s pasireotidom za subkutano uporabo ne kažejo posebnega tveganja za človeka na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih odmerkih, genotoksičnosti in kancerogenega potenciala.
English: Signifor must be given only by deep intramuscular injection.
Slovenian: Zdravilo Signifor se sme dati samo z globokim intramuskularnim injiciranjem.
English: Switch from intramuscular to subcutaneous formulation
Slovenian: Prehod z intramuskularne na subkutano obliko zdravila
English: The percentage of patients achieving biochemical control, including those patients with IGF-1 <LLN was 25.9% in the pasireotide intramuscular use group and 0% in the octreotide intramuscular use group.
Slovenian: Odstotek bolnikov, ki so dosegli biokemijsko urejenost, je vključno z bolniki, pri katerih je bila vrednost faktorja IGF-1 pod spodnjo mejo normalnih vrednosti, znašal 25,9 % v skupini z intramuskularno uporabo pasireotida in 0 % v skupini z intramuskularno uporabo oktreotida.
English: Pasireotide is metabolically highly stable and in vitro data show that pasireotide is not a substrate, inhibitor or inducer of CYP450.
Slovenian: Pasireotid je metabolično zelo stabilen in podatki raziskav in vitro kažejo, da ni substrat, zaviralec ali induktor CYP450.
English: After three months of treatment, patients with a mean 24-hour UFC ≤2 x ULN and below or equal to their baseline value continued blinded treatment at the randomised dose until month 6.
Slovenian: Po treh mesecih zdravljenja so bolniki s povprečno 24-urno vrednostjo UFC ≤2 x ZMN, ki je bila hkrati nižja ali enaka njihovi izhodiščni vrednosti, do konca 6. meseca nadaljevali slepo zdravljenje z odmerkom, ki so jim ga določili pri randomizaciji.
English: 51.6% p=0.536 * Primary endpoint (patients with IGF-1 <lower limit of normal (LLN) were not considered “responders”).
Slovenian: 51,6 % p=0,536 * primarni cilj opazovanja (bolniki z vrednostjo faktorja IGF-1 pod spodnjo mejo normalnih vrednosti (SMN) niso veljali za "bolnike z odzivom")
English: Doses up to 2.1 mg twice a day have been used in healthy volunteers, with the adverse reaction diarrhoea being observed at a high frequency.
Slovenian: Pri zdravih prostovoljcih so uporabljali odmerke do 2,1 mg dvakrat na dan, pri čemer so kot neželeni učinek zelo pogosto opažali diarejo.
English: If hyperglycaemia develops in a patient being treated with Signifor, the initiation or adjustment of antidiabetic treatment is recommended, following the established treatment guidelines for the management of hyperglycaemia.
Slovenian: Če pri bolniku, ki prejema zdravilo Signifor, pride do hiperglikemije, je priporočeno začeti z antidiabetičnim zdravljenjem oziroma prilagoditi odmerjanje antidiabetikov v skladu z veljavnimi smernicami za ukrepanje v primeru hiperglikemije.
English: • beta blockers (metoprolol, carteolol, propranolol, sotalol)
Slovenian: • antagonisti adrenergičnih receptorjev beta (metoprolol, karteolol, propranolol, sotalol)
English: Secondary end-points included, among others, changes from baseline in: 24-hour UFC, plasma ACTH, serum cortisol levels, and clinical signs and symptoms of Cushing's disease.
Slovenian: Sekundarni cilji opazovanja so bile med drugim spremembe od izhodiščnih vrednosti pri: 24-urni vrednosti UFC, vrednosti ACTH v plazmi in vrednosti kortizola v serumu ter pri kliničnih znakih in simptomih Cushingove bolezni.
English: In healthy volunteers, pasireotide is widely distributed with large apparent volume of distribution (Vz/F >100 litres).
Slovenian: Pri zdravih prostovoljcih se pasireotid obsežno porazdeli z velikim navideznim volumnom porazdelitve (Vz/F >100 litrov).
English: During your treatment with Signifor - Signifor controls over-production of cortisol.
Slovenian: V času zdravljenja z zdravilom Signifor - Zdravilo Signifor uravnava prekomerno nastajanje kortizola.
English: This leads the body to over-produce a hormone called adrenocorticotropic hormone (ACTH), which in turn results in over-production of another hormone called cortisol.
Slovenian: Povečanje te žleze povzroči, da v telesu nastaja preveč hormona, ki ga imenujemo adrenokortikotropni hormon (ACTH), zaradi tega pa nastaja preveč drugega hormona, ki ga imenujemo kortizol.
English: At therapeutic dose levels pasireotide is also not an inhibitor of UGT1A1, OATP1B1 or 1B3, OAT1 or OAT3, OCT1 or OCT2, P-gp, BCRP, MRP2 and BSEP.
Slovenian: Pasireotid na ravni terapevtskih odmerkov prav tako ni zaviralec UGT1A1, OATP1B1 ali 1B3, OAT1 ali OAT3, OCT1 ali OCT2, P-gp, BCRP, MRP2 in BSEP.
English: No studies have been conducted to evaluate the absolute bioavailability of pasireotide in humans.
Slovenian: Študij za vrednotenje absolutne biološke uporabnosti pasireotida pri ljudeh niso izvajali.
English: In acromegaly, the safety assessment was made based on 491 patients who received pasireotide (419 patients received pasireotide intramuscular use and 72 received pasireotide subcutaneous use) in phase I, II and III studies.
Slovenian: Pri akromegaliji ocena varnosti temelji na študijah faze I, II in III pri 491 bolnikih, ki so prejemali pasireotid (419 bolnikov je prejemalo pasireotid za intramuskularno uporabo in 72 pasireotid za subkutano uporabo).
English: Sinus bradycardia includes bradycardia and sinus bradycardia.
Slovenian: Sinusna bradikardija vključuje bradikardijo in sinusno bradikardijo.
English: What Signifor contains - The active substance is pasireotide.
Slovenian: Kaj vsebuje zdravilo Signifor - Učinkovina je pasireotid.
English: All analyses were conducted based on the randomised dose groups.
Slovenian: Vse analize so opravili po odmernih skupinah, kot so jih določili pri randomizaciji.
English: As a result, it reduces the symptoms of acromegaly, which include headache, increased sweating, numbness of the hands and feet, tiredness and joint pain.
Slovenian: To omogoča zmanjšanje simptomov akromegalije, ki vključujejo glavobol, prekomerno znojenje, odrevenelost dlani in stopal, utrujenost in bolečine v sklepih.
English: Somatostatin analogues bind to hsst receptors with different potencies (see Table 2).
Slovenian: Analogi somatostatina se različno močno vežejo na receptorje hsst (glejte preglednico 2).