FrancophonIA/ELRC3.0 huggingface dataset:
English: The mean non-renal clearance for meropenem was 4.8 L/h, which comprises both fecal elimination (~2% of the dose) and degradation due to hydrolysis.
Croatian: Srednja vrijednost nebubrežnog klirensa meropenema iznosila je 4,8 l/h, što uključuje i fekalnu eliminaciju (~2% doze) i razgradnju uslijed hidrolize.
English: • Diarrhoea that keeps getting worse or does not go away, or stools that contains blood or mucusthis may happen during or after treatment with Vaborem is stopped.
Croatian: • Proljev koji se pogoršava ili ne prolazi, ili stolica koja sadrži krv ili sluz - to se može dogoditi tijekom ili nakon prestanka liječenja lijekom Vaborem.
English: Concomitant use with valproic acid/sodium valproate/valpromide
Croatian: Istodobna primjena valproatne kiseline/natrijevog valproata/valpromida
English: Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibacterial agents may also be hypersensitive to meropenem/vaborbactam.
Croatian: Bolesnici koji imaju povijest preosjetljivosti na karbapeneme, peniciline ili druge beta-laktamske antibakterijske lijekove mogu također biti preosjetljivi na meropenem/vaborbaktam.
English: Injury, poisoning and procedural complications
Croatian: Ozljede, trovanja i proceduralne komplikacije reakcija povezana s infuzijom
English: The antimicrobial activity of meropenem has been shown to best correlate with the percent of the dosing interval during which the free meropenem concentrations in plasma exceed the meropenem minimum inhibitory concentration.
Croatian: Pokazalo se da je antimikrobna aktivnost meropenema najbolje povezana s postotkom intervala doziranja tijekom kojeg koncentracije slobodnog meropenema u plazmi premašuju minimalnu inhibicijsku koncentraciju meropenema.
English: • a medicine to treat issues with getting an erection in men or to treat high blood pressure in the lungs called sildenafil
Croatian: • lijek za liječenje poteškoća u postizanju erekcije u muškaraca ili za liječenje visokog krvnog tlaka u plućima naziva sildenafil
English: In vitro studies demonstrated no antagonism between meropenem/vaborbactam and levofloxacin, tigecycline, polymyxin, amikacin, vancomycin, azithromycin, daptomycin or linezolid.
Croatian: In vitro ispitivanja pokazala su da ne postoji antagonizam između meropenema/vaborbaktama i levofloksacina, tigeciklina, polimiksina, amikacina, vankomicina, azitromicina, daptomicina ili linezolida.
English: The Cmax and AUC of meropenem and vaborbactam are linear across the dose range studied (1 g to 2 g for meropenem and 0.25 g to 2 g for vaborbactam) when administered as a single 3-hour intravenous infusion.
Croatian: Cmax i AUC meropenema i vaborbaktama su linearni u cjelokupnom ispitivanom rasponu doza (1 g do 2 g za meropenem i 0,25 g do 2 g za vaborbaktam) kada se primjenjuju kao jedna 3-satna intravenska infuzija.
English: • a medicine for gout called probenecid
Croatian: • lijek za giht naziva probenecid
English: Antiglobulin test (Coombs test) seroconversion
Croatian: Serokonverzija pokazana na antiglobulinskom testu (Coombsov test)
English: It is unknown whether vaborbactam is excreted in human milk or animal milk.
Croatian: Nije poznato izlučuje li se vaborbaktam u majčino mlijeko ili mlijeko životinja.
English: If administration of Vaborem is necessary, supplemental anticonvulsant therapy should be considered (see section 4.5).
Croatian: Ako je potrebna primjena lijeka Vaborem, potrebno je razmotriti dodatnu antikonvulzijsku terapiju (vidjeti dio 4.5).
English: Common: (may affect up to 1 in 10 people)
Croatian: Često: (mogu se javiti u do 1 na 10 osoba)
English: The plasma protein binding of meropenem is approximately 2%.
Croatian: Vezanje meropenema na proteine plazme je približno 2%.
English: Dose of Vaborem (meropenem/ vaborbactam)2
Croatian: Doza lijeka Vaborem (meropenem/ vaborbaktam)2
English: • Hospital-acquired pneumonia (HAP), including ventilator associated pneumonia (VAP).
Croatian: • Bolnička pneumonija (HAP), uključujući pneumoniju povezanu s mehaničkom ventilacijom (VAP).
English: How you will be given Vaborem 4.
Croatian: Kako ćete dobivati lijek Vaborem 4. Moguće nuspojave
English: It is important that you tell your doctor if you are breast-feeding or if you intend to breast-feed before receiving Vaborem.
Croatian: Važno je da obavijestite liječnika ako dojite ili ako namjeravate dojiti prije dobivanja lijeka Vaborem.
English: Mechanisms of resistance in Gram-negative bacteria that are known to affect meropenem/vaborbactam include organisms that produce metallo-β-lactamases or oxacillinases with carbapenemase activity.
Croatian: Mehanizami rezistencije u gram-negativnim bakterijama za koje je poznato da utječu na meropenem/vaborbaktam uključuju organizme koji proizvode metalo-β-laktamaze ili oksacilinaze s aktivnošću karbapenemaze.
English: What Vaborem is and what it is used for
Croatian: Što je lijek Vaborem i za što se koristi
English: What you need to know before you are given Vaborem 3.
Croatian: Što morate znati prije nego što dobijete lijek Vaborem
English: Both meropenem and vaborbactam penetrate into human bronchial epithelial lining fluid (ELF) with concentrations around 65% and 79% of unbound plasma concentrations of meropenem and vaborbactam, respectively.
Croatian: Meropenem i vaborbaktam prodiru u tekućinu koja oblaže epitel bronha u ljudi (engl. epithelial lining fluid, ELF) s koncentracijom oko 65% i 79% koncentracije nevezanog meropenema odnosno vaborbaktama u plazmi.
English: Animal studies conducted with meropenem and vaborbactam do not indicate harmful effects with respect to fertility (see section 5.3).
Croatian: Ispitivanja provedena na životinjama s meropenemom i vaborbaktamom ne ukazuju na štetan učinak na plodnost (vidjeti dio 5.3).
English: Talk to your doctor or nurse if you suffer from diarrhoea during your treatment.
Croatian: Obratite se svom liječniku ili medicinskoj sestri ako dobijete proljev tijekom liječenja.
English: Approximately 75 to 95% of vaborbactam is excreted unchanged in the urine over a 24 - 48 hour period.
Croatian: Približno 75% do 95% vaborbaktama izlučuje se u neizmijenjenom obliku u urinu tijekom razdoblja od
English: After reconstitution, 1 ml of the solution contains 50 mg meropenem and 50 mg vaborbactam (see section
Croatian: Nakon rekonstitucije, 1 ml otopine sadrži 50 mg meropenema i 50 mg vaborbaktama (vidjeti dio 6.6).
English: Clinical efficacy has not been established against the following pathogens that are relevant to the approved indications although in vitro studies suggest that they would be susceptible to meropenem and/or meropenem/vaborbactam in the absence of acquired mechanisms of resistance.
Croatian: Nije utvrđena klinička djelotvornost protiv sljedećih patogena koji su relevantni za odobrene indikacije iako ispitivanja in vitro upućuju da bi bili osjetljivi na meropenem i/ili meropenem/vaborbaktam u nedostatku stečenih mehanizama rezistencije.
English: There is no experience with overdose of Vaborem.
Croatian: Nema iskustva s predoziranjem lijekom Vaborem.
English: Following dilution, the infusion should be completed within 4 hours when stored at 25° C, or within 22 hours when refrigerated at 2 - 8 °C.
Croatian: Nakon razrjeđivanja, infuzija mora biti dovršena unutar 4 sata kada se čuva na 25° C, ili unutar 22 sata kada se čuva u hladnjaku na 2 - 8 °C.
English: • you have ever had any allergic reaction to other antibiotics belonging to the beta-lactam group
Croatian: • ako ste imali bilo koju alergijsku reakciju na druge antibiotike koji pripadaju skupini beta-laktama
English: Talk to your doctor or nurse before receiving Vaborem if:
Croatian: Obratite se svom liječniku ili medicinskoj sestri prije nego primite lijek Vaborem:
English: Other medicines and Vaborem Tell your doctor if you are using, have recently used or might use any other medicines.
Croatian: Obavijestite svog liječnika ako primjenjujete, nedavno ste primijenili ili biste mogli primijeniti bilo koje druge lijekove.
English: Carcinogenicity studies have not been conducted with vaborbactam.
Croatian: Nisu provedena ispitivanja kancerogenosti s vaborbaktamom.
English: What Vaborem is Vaborem is an antibiotic medicine that contains two active substances: meropenem and vaborbactam.
Croatian: Lijek Vaborem je antibiotik koji sadrži dvije djelatne tvari: meropenem i vaborbaktam.
English: The use of Vaborem to treat patients with infections due to bacterial organisms who have limited treatment options is based on pharmacokinetic/pharmacodynamic analyses for meropenem/vaborbactam and on limited data from a randomised clinical trial in which 32 patients were treated with Vaborem and 15 patients were treated with best available therapy for infections caused by carbapenem-resistant organisms (see section 5.1).
Croatian: Primjena lijeka Vaborem u liječenju bolesnika s infekcijama uzrokovanima bakterijskim organizmima koji imaju ograničenu mogućnost liječenja temelji se na farmakokinetičkoj/farmakodinamičkoj analizi meropenema/vaborbaktama te na ograničenim podacima iz randomiziranog kliničkog ispitivanja u kojem je 32 bolesnika primalo lijek Vaborem i 15 bolesnika primalo najbolju dostupnu terapiju za infekcije uzrokovane organizmima otpornima na karbapenem (vidjeti dio 5.1).
English: Infusion Time
Croatian: Vrijeme infuzije
English: Sodium carbonate
Croatian: Natrijev karbonat
English: Caution should be used when administering meropenem/vaborbactam concomitantly with medicinal products with a narrow therapeutic window that are predominantly metabolised by CYP450 enzymes (e.g. immunosuppressants such as tacrolimus, everolimus and cyclosporine, lovastatin, midazolam, sildenafil and warfarin) as conclusive data on whether meropenem or vaborbactam may be inhibitors or inducers of CYP450 enzymes is not yet available.
Croatian: Potreban je oprez kod istodobne primjene meropenema/vaborbaktama i lijekova s uskom terapijskom širinom koji se pretežno metaboliziraju enzimima CYP450 (npr. imunosupresivi kao što su takrolimus, everolimus i ciklosporini, lovastatin, midazolam, sildenafil i varfarin) jer konačni podaci o tome jesu li meropenem ili vaborbaktam inhibitori ili induktori enzima CYP450 nisu još dostupni.
English: • Sudden onset of a severe rash with bullseye-like spots or blistering or peeling skin, possibly with a high fever, joint pain, abnormal function of your liver, kidney or lung (these may be signs of more serious medical conditions called toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme or a condition known as drug reaction with eosinophilia and systemic symptoms (DRESS))
Croatian: • iznenadna pojava teškog osipa s okruglim točkama ili mjehurićima ili ljuštenjem kože, uz moguću visoku vrućicu, bolove u zglobovima, poremećenu funkciju jetre, bubrega ili pluća (to mogu biti znakovi ozbiljnijeg zdravstvenog stanja naziva toksična epidermalna nekroliza, Stevens-Johnsonov sindrom, multiformni eritem, ili stanje poznato kao reakcija na lijek s eozinofilijom i sistemskim simptomima (DRESS))
English: This should be taken into consideration while treating patients on a controlled sodium diet.
Croatian: O tome treba voditi računa dok liječite bolesnike koji su na dijeti s kontroliranim unosom natrija.
English: Tell your doctor that you are taking Vaborem if you are going to have any blood tests.
Croatian: Obavijestite svog liječnika da uzimate lijek Vaborem ako ćete se podvrgnuti krvnim pretragama.
English: There are no or limited amount of data (less than 300 pregnancy outcomes) from the use of meropenem/vaborbactam in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni meropenema/vaborbaktama u trudnica ograničeni (manje od 300
English: • Swelling and irritation in the large intestine or colon - this can cause diarrhoea, fever and stomach cramps and is due to another colon infection
Croatian: • oticanje i nadraženost debelog crijeva ili kolona - to može izazvati proljev, vrućicu i grčeve u želucu i posljedica je druge infekcije kolona
English: Patients taking CYP2D6 substrates with narrow therapeutic index (e.g. dextromethorphan, desipramine, venlafaxine, and metoprolol) should be monitored for signs of toxicity.
Croatian: Potrebno je pratiti bolesnike koji uzimaju supstrate CYP2D6 uskog terapijskog indeksa (npr. dekstrometorfan, dezipramin, venlafaksin i metoprolol) kako bi se uočili znakovi toksičnosti.
English: The elimination of vaborbactam by the kidneys resulted in high concentrations in the urine.
Croatian: Eliminacija vaborbaktama putem bubrega rezultirala je visokim koncentracijama u urinu.
English: Intravenous use after reconstitution and dilution
Croatian: Za intravensku primjenu nakon rekonstitucije i razrjeđivanja
English: For vaborbactam, the PK-PD index associated with antimicrobial activity is the ratio of free vaborbactam plasma AUC: meropenem/vaborbactam MIC.
Croatian: Za vaborbaktam, indeks PK-PD vezan uz antimikrobnu aktivnost je omjer AUC slobodnog vaborbaktama u plazmi: MIK meropenema/vaborbaktama.
English: It is also used to treat infections
Croatian: • pluća (upala pluća) Koristi se također za liječenje infekcija
English: Therefore, supplemental anticonvulsant therapy should be administered when concomitant administration of valproic acid and meropenem/vaborbactam cannot be avoided (see section 4.4).
Croatian: Stoga je potrebno primijeniti dodatnu antikonvulzijsku terapiju kada se istodobna primjena valproatne kiseline i meropenema/vaborbaktama ne može izbjeći (vidjeti dio 4.4).
English: The inhibitory spectrum of vaborbactam includes class A carbapenemases (such as KPC) and Class C carbapenemases.
Croatian: Inhibicijski spektar vaborbaktama uključuje karbapenemaze klase A (kao što je KPC) i klase C.
English: Carcinogenicity studies have not been conducted with meropenem.
Croatian: Nisu provedena ispitivanja kancerogenosti s meropenemom.
English: A positive direct or indirect Coombs test may develop during treatment with meropenem/vaborbactam as seen with meropenem (see section 4.8).
Croatian: Pozitivni direktni i indirektni Coombsov test može se razviti tijekom liječenja meropenemom/vaborbaktamom kao što je viđeno s meropenemom (vidjeti dio 4.8).
English: Co-administration of probenecid with Vaborem is not recommended, as it may result in increased plasma concentrations of meropenem.
Croatian: Ne preporučuje se istodobna primjena probenecida s lijekom Vaborem jer može rezultirati povećanim koncentracijama meropenema u plazmi.
English: Hepatic function should be closely monitored during treatment with meropenem/vaborbactam due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis) (see section 4.8).
Croatian: Potrebno je pažljivo nadzirati funkciju jetre tijekom liječenja meropenemom/vaborbaktamom zbog rizika od hepatotoksičnosti (disfunkcija jetre s kolestazom i citolizom) (vidjeti dio 4.8).
English: Each vial contains 10.9 mmol of sodium (approximately 250 mg).
Croatian: Jedna bočica sadrži 10,9 mmol natrija (približno 250 mg).
English: Mechanisms of bacterial resistance that could decrease the antibacterial activity of meropenem/vaborbactam include porin mutations affecting outer membrane permeability and overexpression of efflux pumps.
Croatian: Mehanizmi bakterijske rezistencije koji mogu smanjiti antibakterijsku aktivnost meropenema/vaborbaktama uključuju mutacije porina koje utječu na propusnost vanjske membrane i pretjeranu ekspresiju efluks-pumpi.
English: Vaborem is also indicated for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treatment options (see sections 4.2, 4.4 and 5.1).
Croatian: Lijek Vaborem je također indiciran za liječenje infekcija uzrokovanih aerobnim Gram-negativnim organizmima u odraslih bolesnika s ograničenim mogućnostima liječenja (vidjeti dijelove 4.2, 4.4 i 5.1).
English: MARKETING AUTHORISATION NUMBER(S) EU/1/18/1334/001
Croatian: EU/1/18/1334/001
English: Vaborem has moderate influence on the ability to drive and use machines.
Croatian: Lijek Vaborem umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Hospital-acquired pneumonia, including ventilator-associated pneumonia The use of Vaborem to treat patients with hospital-acquired pneumonia, including ventilator-associated pneumonia, is based on experience with meropenem alone and pharmacokinetic-pharmacodynamic analyses for meropenem/vaborbactam.
Croatian: Bolnička pneumonija, uključujući pneumoniju povezanu s mehaničkom ventilacijom Primjena lijeka Vaborem u liječenju bolesnika s bolničkom pneumonijom, uključujući pneumoniju povezanu s mehaničkom ventilacijom, temelji se na iskustvu sa samim meropenemom i farmakokinetičkoj-farmakodinamičkoj analizi za meropenem/vaborbaktam.
English: The elimination of meropenem by the kidneys resulted in high therapeutic concentrations in urine.
Croatian: Eliminacija meropenema putem bubrega rezultirala je visokim terapijskim koncentracijama u urinu.
English: 50 ml clear glass vial (Type 1) closed with a rubber (bromobutyl) stopper and aluminium overseal with flip-off cap.
Croatian: Bočica od prozirnog stakla (tipa 1) od 50 ml zatvorena gumenim (bromobutil) čepom i aluminijskim prstenom sa flip-off zatvaračem.
English: Vaborbactam has no antibacterial activity.
Croatian: Vaborbaktam nema anibakterijsku aktivnost.
English: Meropenem has been reported to be excreted in human milk.
Croatian: Prijavljeno je da se meropenem izlučuje u majčino mlijeko.
English: Hypersensitivity to any carbapenem antibacterial agent.
Croatian: Preosjetljivost na bilo koji antibakterijski lijek iz kategorije karbapenema.
English: Adverse reactions listed in the table with a frequency of “unknown” were not observed in patients participating in trials with Vaborem or meropenem, but have been reported in the post-marketing setting for meropenem alone.
Croatian: Nuspojave navedene u tablici s učestalošću „nepoznato“ nisu zabilježene u bolesnika koji su sudjelovali u ispitivanjima s lijekom Vaborem ili meropenemom, ali su prijavljene u razdoblju nakon stavljanja lijeka u promet za sami meropenem.
English: This is because you may get an abnormal result with something called a “Coombs test”.
Croatian: To je zato što nalaz dobiven testom koji se zove „Coombsov test“ može biti poremećen.
English: This medicinal product must not be mixed with other medicinal products except those mentioned in section 6.6 of the SmPC.
Croatian: Ovaj lijek se ne smije miješati s drugim lijekovima, osim onih navedenih u dijelu 6.6 sažetka opisa svojstava lijeka.
English: Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above.
Croatian: Liječenje bolesnika s bakterijemijom koja se javlja vezano uz bilo koju od navedenih infekcija, ili na koju se sumnja da je povezana sa bilo kojom od navedenih infekcija.
English: Patients with pre-existing liver disorders should have liver function monitored during treatment with meropenem/vaborbactam.
Croatian: Bolesnicima s postojećim poremećajima jetre potrebno je pratiti funkciju jetre tijekom liječenja meropenemom/vaborbaktamom.
English: • The following reactions may develop, alone or in combination, where Vaborem is given into a vein: reddened skin (erythema); hot, tender and swollen vein around the needle (phlebitis); a blood clot in the vein where the needle was put through your skin (infusion site thrombosis)
Croatian: • mogu se razviti sljedeće reakcije, same ili u kombinaciji, kada se lijek Vaborem primjenjuje u venu: crvenilo kože (eritem); vruća, osjetljiva i otečena vena oko igle (flebitis); ugrušak u veni gdje je igla ubodena u kožu (tromboza na mjestu infuzije) • bol
English: Your doctor may also want to do some blood tests to see how well your kidneys are working.
Croatian: Vaš liječnik može uzeti uzorak krvi da provjeri koliko dobro radi
English: Vaborem will be given to you by a doctor or nurse by infusion (a drip) into a vein, lasting 3 hours.
Croatian: Kako ćete dobivati lijek Vaborem Lijek Vaborem će Vam dati liječnik ili medicinska sestra infuzijom (kapanjem) u venu u trajanju od 3
English: Severe hypersensitivity (e.g. anaphylactic reaction, severe skin reaction) to any other type of beta-lactam antibacterial agent (e.g. penicillins, cephalosporins or monobactams).
Croatian: Teška preosjetljivost (npr. anafilaktička reakcija, teška kožna reakcija) na bilo koju drugu vrstu betalaktamskih antibakterijskih lijekova (npr. penicilini, cefalosporini ili monobaktami).
English: There is no dose adjustment necessary (see section 4.2).
Croatian: Nije potrebno prilagođavati dozu (vidjeti dio 4.2).
English: Meropenem and vaborbactam can be removed by haemodialysis.
Croatian: Meropenem i vaborbaktam mogu se ukloniti hemodijalizom.
English: Concomitant administration of meropenem and valproic acid has been associated with reductions in valproic acid concentrations with subsequent loss in seizure control.
Croatian: Istodobna primjena meropenema i valproatne kiseline povezana je sa smanjenjem koncentracija valproatne kiseline s posljedičnim gubitkom kontrole napadaja.
English: Therefore, you must discontinue breastfeeding before you are given Vaborem.
Croatian: Stoga morate prekinuti dojenje prije nego što dobijete lijek Vaborem.
English: Vaborbactam
Croatian: Vaborbaktam
English: Meropenem exerts bactericidal activity by inhibiting peptidoglycan cell wall synthesis as a result of binding to and inhibition of activity of essential penicillin-binding proteins (PBPs).
Croatian: Meropenem ima baktericidno djelovanje tako što inhibira sintezu peptidoglikanske stanične stijenke kao rezultat vezanja za esencijalne proteine koji vežu penicilin (PBP) i inhibicije njihove aktivnosti.
English: This product contains approximately 250 mg of sodium per vial.
Croatian: Ovaj lijek sadrži približno 250 mg natrija po bočici.
English: • A tingling feeling (pins and needles)
Croatian: • osjećaj trnaca (bockanja i iglica)
English: A. Menarini Pharma GmbH Tel: +43 1 879 95 85-0
Croatian: Menarini Pharma GmbH Tel: +43 1 879 95 85-0
English: In the event of overdose, discontinue Vaborem and institute general supportive treatment.
Croatian: U slučaju predoziranja, prekinite terapiju lijekom Vaborem i uspostavite opće potporno liječenje.
English: Pharmacokinetic data from a population pharmacokinetic analysis showed a reduction in plasma clearance of meropenem/vaborbactam that correlates with age-associated reduction in creatinine clearance.
Croatian: Farmakokinetički podaci iz populacijske farmakokinetičke analize pokazali su smanjenje u klirensu meropenema/vaborbaktama u plazmi koji je povezan sa smanjenjem klirensa kreatinina vezanim uz dob.
English: Both meropenem and vaborbactam are primarily excreted via the kidneys.
Croatian: Meropenem i vaborbaktam se prvenstveno izlučuju putem bubrega.
English: Vaborem should be used to treat infections due to aerobic Gram-negative organisms in adult patients with limited treatment options only after consultation with a physician with appropriate experience in the management of infectious diseases (see sections 4.4 and 5.1).
Croatian: Lijek Vaborem je potrebno primjenjivati za liječenje infekcija uzrokovanih aerobnim Gram-negativnim organizmima u odraslih bolesnika s ograničenim mogućnostima liječenja tek nakon savjetovanja s liječnikom koji ima odgovarajuće iskustvo u liječenju infektivnih bolesti (vidjeti dijelove 4.4 i 5.1).
English: • Tremor or shaking
Croatian: • omaglica • tremor ili tresenje
English: Vaborem may make you feel dizzy, sleepy and sluggish, give you a headache or tingling sensation (like “pins and needles”) or, in rare cases, cause a fit or seizure.
Croatian: Lijek Vaborem može izazvati omaglicu, pospanost i tromost, glavobolju ili trnce (poput „bockanja i iglica“) ili, u rijetkim slučajevima, uzrokovati napadaje ili konvulzije.
English: Doses adjusted for renal impairment should be administered after a dialysis session.
Croatian: Doze prilagođene za oštećenje funkcije bubrega trebaju se primijeniti nakon postupka dijalize.