FrancophonIA/ELRC3.0 huggingface dataset:
English: Caution is warranted and therapeutic concentration monitoring, if available, is recommended for these antiarrhythmics when coadministered with boosted darunavir.
Slovenian: Pri sočasni uporabi z okrepljenim darunavirjem je potrebna previdnost, priporočljivo pa je spremljanje terapevtskih koncentracij navedenih antiaritmikov, če je na voljo.
English: Caution is warranted and clinical monitoring is recommended.
Slovenian: Potrebna je previdnost in klinično spremljanje bolnika.
English: Co-administration of boosted darunavir with clonazepam may increase concentrations of clonazepam.
Slovenian: Sočasna uporaba okrepljenega zdravila darunavir s klonazepamom lahko zviša koncentracije klonazepama.
English: The combination of rifapentine and darunavir with concomitant low dose ritonavir is not recommended.
Slovenian: Kombinacija rifapentina in darunavirja skupaj z majhnim odmerkom ritonavirja ni priporočljiva.
English: Dexamethasone (corticosteroid)
Slovenian: deksametazon (sistemskaoblika)
English: However, adjustment of the methadone dose may be necessary when concomitantly administered for a longer period of time.
Slovenian: Pri dolgotrajnejši sočasni uporabi bo morda treba prilagoditi odmerek metadona.
English: Darunavir Krka 400 mg film-coated tablets:
Slovenian: Darunavir Krka 400 mg filmsko obložene tablete:
English: The recommendations given for concomitant use of darunavir and other medicinal products may therefore differ depending on whether darunavir is boosted with ritonavir or cobicistat (see sections 4.3 and 4.4), and caution is also required during the first time of treatment if switching the pharmacoenhancer from ritonavir to cobicistat (see section 4.4).
Slovenian: Interakcije darunavirja se razlikujejo in so odvisne od tega, ali je farmakokinetični ojačevalec ritonavir ali kobicistat, zato so tudi priporočila za sočasno uporabo darunavirja z drugimi zdravili lahko različna, odvisno od tega, ali je darunavir okrepljen z ritonavirjem ali s kobicistatom (glejte poglavji 4.3 in 4.4).
English: Based on theoretical considerations darunavir co-administered with cobicistat is expected to increase metformin plasma concentrations.
Slovenian: Po teoretični presoji se pri sočasni uporabi darunavirja s kobicistatom pričakuje zvišanje plazemskih koncentracij metformina.
English: Dexamethasone (systemic) Not studied.
Slovenian: deksametazon (sistemska oblika)
English: Number of baseline mutations
Slovenian: (velike) mutacije
English: Concominant administration of darunavir with low dose ritonavir and lurasidone, pimozide or sertindole is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba darunavirja skupaj z majhnim odmerkom ritonavirja in z lurazidonom, s pimozidom ali sertindolom je kontraindicirana (glejte poglavje 4.3).
English: Darunavir Krka 400 mg film-coated tablets Darunavir Krka 800 mg film-coated tablets
Slovenian: Darunavir Krka 400 mg filmsko obložene tablete Darunavir Krka 800 mg filmsko obložene tablete
English: Bottle (HDPE), child resistant temper evident PP closure with a desiccant: - 30 tablets: 1 bottle of 30 film-coated tablets, - 90 tablets.
Slovenian: Plastenka (HDPE), za otroke varna polipropilenska zaporka s sušilnim sredstvom, ki je ni mogoče odpreti brez vidnih poškodb: - 30 tablet: 1 plastenka s 30 filmsko obloženimi tabletami - 90 tablet: 3 plastenke s 30 filmsko obloženimi tabletami
English: Therefore, therapy with darunavir/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with darunavir/cobicistat should be switched to an alternative regimen (see sections 4.2 and 4.6).
Slovenian: Zato se zdravljenja s kombinacijo darunavir/kobicistat ne sme uvesti med nosečnostjo, pri ženskah, ki med zdravljenjem s to kombinacijo zanosijo, pa je treba razmisliti o prehodu na drug režim zdravljenja (glejte poglavji 4.2 in 4.6).
English: Bottle (HDPE), child resistant temper evident PP closure with a desiccant: - 30 tablets: 1 bottle of 30 film-coated tablets, - 60 tablets: 2 bottles of 30 film-coated tablets, - 90 tablets: 3 bottles of 30 film-coated tablets, - 180 tablets: 6 bottles of 30 film-coated tablets.
Slovenian: Plastenka (HDPE), za otroke varna polipropilenska zaporka s sušilnim sredstvom, ki je ni mogoče odpreti brez vidnih poškodb: - 30 tablet: 1 plastenka s 30 filmsko obloženimi tabletami - 60 tablet: 2 plastenki s 30 filmsko obloženimi tabletami - 90 tablet: 3 plastenke s 30 filmsko obloženimi tabletami - 180 tablet:6 plastenk s 30 filmsko obloženimi tabletami
English: Applicable to darunavir boosted with cobicistat, not when boosted with ritonavir: Darunavir boosted with cobicistat is more sensitive for CYP3A induction than darunavir boosted with ritonavir.
Slovenian: - Darunavir, okrepljen s kobicistatiom, je bolj občutljiv za indukcijo s CYP3A kot darunavir, okrepljen z ritonavirjem.
English: A dosage reduction of rifabutin by 75% of the usual dose of 300 mg/day (i.e. rifabutin 150 mg once every other day) and increased monitoring for rifabutin related adverse events is warranted in patients receiving the combination with darunavir co-administered with ritonavir.
Slovenian: kombinacijo darunavirja in ritonavirja, je priporočljivo zmanjšanje običajnega odmerka 300 mg/dan rifabutina za 75 % (to je 150 mg rifabutina enkrat vsak drugi dan) in povečano spremljanje z rifabutinom povezanih neželenih učinkov.
English: Outcomes darunavir / ritonavir 600/100 mg twice daily n=131
Slovenian: Izidi darunavir/ritonavir 600/100 mg dvakrat na dan n = 131
English: Each film-coated tablet contains 800 mg darunavir.
Slovenian: Ena filmsko obložena tableta vsebuje 800 mg darunavirja.
English: Therefore, therapy with darunavir/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with darunavir/cobicistat should be switched to an alternative regimen (see sections 4.4 and 4.6).
Slovenian: Zato se zdravljenja s kombinacijo darunavir/kobicistat ne sme uvesti med nosečnostjo, pri ženskah, ki med zdravljenjem s to kombinacijo zanosijo, je treba preiti na drug režim zdravljenja (glejte poglavji 4.4 in 4.6).
English: Number of subjects with virologic failure and paired baseline/endpoint phenotypes, showing loss of susceptibility to PIs at endpoint compared to baseline, n/N PI darunavir amprenavir atazanavir indinavir lopinavir saquinavir tipranavir
Slovenian: Število virološko neuspešnih bolnikov in fenotipi pred in po zdravljenju, ki kažejo izgubo občutljivosti za PI ob zaključku v primerjavi z začetkom preskušanja, n/N PI darunavir amprenavir atazanavir indinavir lopinavir sakvinavir tipranavir ne-VF (virologic failure) cenzuriran algoritem TLOVR (time to loss of virologic response), na osnovi HIV-1 RNK < 50 kopij/ml, razen za preskušanje TITAN (HIV-1 RNK < 400 kopij/ml) po seznamih IAS-USA (International AIDS Society-USA)
English: Concomitant use of boosted darunavir and these antidepressants may increase concentrations of the antidepressant.
Slovenian: Sočasna uporaba okrepljenega darunavirja z navedenimi antidepresivi lahko zviša njihove koncentracije.
English: 450 mg darunavir /60 mg ritonavir twice daily
Slovenian: 450 mg darunavirja/60 mg ritonavirja dvakrat na dan
English: The pharmacokinetics of darunavir in combination with ritonavir taken once daily in 12 ART-naïve paediatric patients, aged 12 to < 18 years and weighing at least 40 kg, showed that darunavir/ritonavir 800/100 mg once daily results in darunavir exposure that was comparable to that achieved in adults receiving darunavir/ritonavir 800/100 mg once daily.
Slovenian: Farmakokinetika darunavirja v kombinaciji z ritonavirjem enkrat na dan pri 12 pediatričnih bolnikih, starih 12 do < 18 let in s telesno maso najmanj 40 kg, ki še niso bili zdravljeni z ART, je pokazala, da jemanje zdravil darunavir/ritonavir 800/100 mg enkrat na dan vodi v izpostavljenost darunavirju, ki je primerljiva izpostavljenosti, doseženi pri odraslih bolnikih, ki so prejemali zdravili darunavir/ritonavir 800/100 mg enkrat na dan.
English: Co-administration of domperidone with boosted darunavir is contraindicated.
Slovenian: Sočasna uporaba domperidona in okrepljenega darunavirja je kontraindicirana.
English: Darunavir Krka 600 mg film-coated tablets
Slovenian: Darunavir Krka 600 mg filmsko obložene tablete
English: Boosted darunavir and raltegravir can be used without dose adjustments.
Slovenian: Okrepljen darunavir in dolutegravir se lahko uporabljata brez prilagajanja odmerkov.
English: Co-administration of darunavir coadministered with cobicistat and rifabutin is not recommended.
Slovenian: Sočasna uporaba darunavirja s kobicistatom in z rifabutinom ni priporočljiva.
English: not known toxic epidermal necrolysis*, acute generalised exanthematous pustulosis*
Slovenian: neznana pogostnost toksična epidermalna nekroliza*, akutna generalizirana eksantematozna pustuloza* Bolezni mišično-skeletnega sistema in vezivnega tkiva Pogosti mialgija
English: Postpartum (6-12 weeks) (n=6)
Slovenian: Obdobje po porodu (6-12 tednov) (n=6)
English: It is not recommended to alter the dose of cobicistat or ritonavir.
Slovenian: Odmerka kobicistata ali ritonavirja ni priporočljivo spreminjati.
English: ART-experienced paediatric patients from the age of 6 to < 18 years and weighing at least 20 kg DELPHI is an open-label, Phase II trial evaluating the pharmacokinetics, safety, tolerability, and efficacy of darunavir with low dose ritonavir in 80 ART-experienced HIV-1 infected paediatric patients aged 6 to 17 years and weighing at least 20 kg.
Slovenian: Pediatrični bolniki, ki imajo izkušnje z ART, stari 6 do< 18 let in s telesno maso najmanj 20 kg DELPHI je odprto preskušanje faze II, v katerem so ocenjevali farmakokinetiko, varnost, prenosljivost in učinkovitost darunavirja skupaj z majhnim odmerkom ritonavirja pri 80 s HIV-1 okuženih pediatričnih bolnikih (starih 6 do 17 let in s telesno maso najmanj 20 kg), ki so že imeli izkušnje z ART. Ti bolniki so prejeli darunavir/ritonavir dvakrat na dan v kombinaciji z drugimi protiretrovirusnimi zdravili (priporočila za odmerjanje glede na telesno maso so navedena v poglavju 4.2).
English: Drug-induced hepatitis (e.g. acute hepatitis, cytolytic hepatitis) has been reported with darunavir.
Slovenian: Pri uporabi darunavirja se je pojavil hepatitis, povezan z zdravilom (akutni hepatitis, citolitični hepatitis).
English: Postpartum (6-12 weeks) (n=16)
Slovenian: Obdobje po porodu (6-12 tednov) ( n = 16)
English: Based on theoretical considerations darunavir is expected to increase alfuzosin plasma concentrations.
Slovenian: Po teoretični presoji se pri sočasni uporabi darunavirja z alfuzosinom pričakuje zvišanje plazemskih koncentracij.
English: Co-administration of darunavir and ritonavir with medicinal products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Slovenian: Sočasna uporaba darunavirja in ritonavirja z zdravili, ki se presnavljajo predvsem s CYP2C9 (varfarin) in CYP2C19 (metadon), lahko povzroči zmanjšanje sistemske izpostavljenosti tem zdravilom, kar lahko zmanjša ali skrajša njihov terapevtski učinek.
English: For clinical trial results in ART-naïve adult patients, refer to the Summary of Product Characteristics for Darunavir Krka 400 mg and 800 mg tablets.
Slovenian: Rezultati kliničnih preskušanj pri bolnikih, ki še nimajo izkušenj z ART, so navedeni v Povzetku glavnih značilnosti zdravila Darunavir Krka 400 mg in 800 mg tablete.
English: No dose adjustment is required for darunavir/ritonavir during pregnancy and postpartum.
Slovenian: Med nosečnostjo in v obdobju po porodu prilagajanje odmerka zdravil darunavir/ritonavir ni potrebno.
English: How to store Darunavir Krka
Slovenian: Kako jemati zdravilo Darunavir Krka
English: When administered concomitantly with darunavir and low dose ritonavir, the patient's tolerability of bosentan should be monitored.
Slovenian: Ob sočasni uporabi z darunavirjem in majhnim odmerkom ritonavirja je treba spremljati, kako bolnik prenaša bosentan.
English: Concomitant use of bosentan and boosted darunavir may increase plasma concentrations of bosentan.
Slovenian: bosentana in okrepljenega darunavirja lahko zviša plazemske koncentracije bosentana.
English: In women receiving darunavir/cobicistat during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC24h and Cmin were 49%, 56% and 92% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC24h and Cmin values were 37%, 50% and 89% lower, respectively, as compared with postpartum.
Slovenian: Pri ženskah, ki so prejemale kombinacijo darunavir/kobicistat v drugem trimesečju nosečnosti, so bile med posameznicami povprečne vrednosti celokupnega darunavirja Cmax, AUC24h in Cmin nižje za 49%, 56% oziroma 92% kot v obdobju po porodu.
English: Always use this medicine exactly as described in this leaflet or as your doctor, pharmacist or nurse has told you.
Slovenian: Pri jemanju tega zdravila natančno upoštevajte navodila zdravnika, farmacevta ali medicinske sestre.
English: Hence, concomitant use of darunavir coadministered with low dose ritonavir and the combination product lopinavir/ritonavir is contraindicated (see section 4.3).
Slovenian: Zato je sočasna uporaba darunavirja z majhnim odmerkom ritonavirja in kombinacije zdravil lopinavir/ritonavir kontraindicirana (glejte poglavje 4.3).
English: Co-administration of darunavir and ritonavir and medicinal products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Slovenian: Sočasna uporaba darunavirja, ritonavirja in zdravil, ki se presnavljajo predvsem s CYP2C9 (varfarin) in CYP2C19 (metadon), lahko povzroči zmanjšanje sistemske izpostavljenosti tem zdravilom, kar lahko zmanjša ali skrajša njihov terapevtski učinek.
English: If parenteral midazolam is co-administered with darunavir co-administered with low dose ritonavir it may cause a large increase in the concentration of this benzodiazepine.
Slovenian: Sočasna uporaba parenteralnega midazolama in darunavirja skupaj z majhnim odmerkom ritonavirja lahko povzroči veliko zvišanje koncentracije tega benzodiazepina.
English: Each film-coated tablet contains 400 mg darunavir.
Slovenian: Ena filmsko obložena tableta vsebuje 400 mg darunavirja.
English: When administration of atorvastatin and boosted darunavir is desired, it is recommended to start with an atorvastatin dose of 10 mg once daily.
Slovenian: Če želite uporabljati atorvastatin in okrepljen darunavir, je priporočljivo začeti z odmerkom atorvastatina 10 mg enkrat na dan. Glede na klinični odziv bolnika lahko odmerek atorvastatina postopoma zvečate.
English: Proportion (%) of patients with response (HIV-1 RNA < 50 copies/ml at week 24) to darunavir coadministered with ritonavir (600/100 mg twice daily) by baseline genotype a, and baseline darunavir
Slovenian: Delež (%) bolnikov z odzivom (HIV-1 RNK < 50 kopij/ml v 24. tednu) na darunavir z ritonavirjem (600/100 mg dvakrat na dan) glede na genotip ob začetku zdravljenja in FC darunavirja ob začetku zdravljenja ter po uporabi enfuvirtida (ENF): Kot obravnavano v analizi preskušanj POWER in DUET.
English: Concomitant use of boosted darunavir and elbasvir/grazoprevir is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba okrepljenega darunavirja in kombinacije zdravil elbasvir/grazoprevir je kontraindicirana (glejte poglavje 4.3).
English: TREATMENT FOR PREMATURE EJACULATION
Slovenian: PODATKI NA PRIMARNIOVOJNINI
English: Amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine to treat certain heart disorders e.g. abnormal heart beat Lovastatin, simvastatin and lomitapide to lower cholesterol levels Rifampicin to treat some infections such as tuberculosis
Slovenian: zdravljenje migrenskih glavobolov amjodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin zdravljenje določenih bolezni srca, npr. motenj srčnega ritma lovastatin, simvastatin in lomitapid zniževanje holesterola v krvi rifampicin zdravljenje nekaterih okužb, kot je tuberkuloza kombinacija zdravillopinavir/ritonavir zdravljenje okužbe z virusomHIV, zdravilo je uvrščeno v isto skupino kot zdravilo Darunavir Krka elbasvir/grazoprevir za zdravljenje okužbe z virusom hepatitisa C
English: Pharmacokinetic results of total darunavir after administration of darunavir/ritonavir at 600/100 mg twice daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy and postpartum
Slovenian: Rezultati farmakokinetike celokupnega darunavirja po jemanju zdravil darunavir/ritonavir v odmerkih 600/100 mg dvakrat na dan kot del protiretrovirusnega zdravljenja med drugim in tretjim trimesečjem nosečnosti ter v obdobju po porodu
English: Abacavir Emtricitabine Lamivudine Stavudine Zidovudine
Slovenian: abakavir emtricitabin lamivudin stavudin zidovudin
English: Iron oxide, yellow (E172) - only for 400 mg film-coated tablets Iron oxide, red (E172)
Slovenian: polivinilalkohol makrogol titanov dioksid (E171) smukec (E553b) rumeni železov oksid (E172) - samo v 400 mg filmsko obloženih tabletah rdeči železov oksid (E172)
English: Rare side effects (may affect up to 1 in 1,000 people) a reaction called DRESS [severe rash, which may be accompanied by fever, fatigue, swelling of the face or lymph glands, increase of eosinophils (type of white blood cells), effects on liver, kidney or lung] heart attack, slow heart beating, palpitations visual disturbance chills, feeling abnormal a feeling of confusion or disorientation, altered mood, restlessness fainting, epileptic fits, changes or loss of taste mouth sores, vomiting blood, inflamation of the lips, dry lips, coated tongue running nose skin lesions, dry skin stiffness of muscles or joints, joint pain with or without inflammation changes in some values of your blood cells or chemistry.
Slovenian: Redki neželeni učinki (pojavijo se lahko pri največ 1 od 1.000 bolnikov) - reakcija, ki jo imenujemo DRESS (hud izpuščaj, ki ga včasih spremlja zvišana telesna temperatura, utrujenost, otekanje obraza in bezgavk, zvečano število eozinofilcev (vrsta belih krvnih celic), učinki na jetra, ledvice ali pljuča) - srčni infarkt, počasno bitje srca, palpitacije (močno bitje srca) - motnje vida - mrzlica, nenavadno počutje - stanje zmedenosti ali dezorientacije, spremembe razpoloženja, nemir - omedlevica, epileptični napadi, spremembe ali izguba okusa - razjede v ustih, bruhanje krvi, vnetje ustnic, suha usta, obložen jezik - izcedek iz nosu - razjede na koži, suha koža - okorelost mišic ali sklepov,bolečina v sklepih z vnetjem ali brez vnetja - spremembe v vrednostih nekaterih krvnih celic ali kemijskih parametrov.
English: Concominant administration of boosted darunavir and lurasidone, pimozide or sertindole is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba okrepljenega darunavirja z lurazidonom, s pimozidom ali sertindolom je kontraindicirana (glejte poglavje 4.3).
English: Amiodarone Bepridil Dronedarone Ivabradine Quinidine Ranolazine
Slovenian: ANTIARITMIKI/ZDRAVILA ZA ZDRAVLJENJE ANGINE PEKTORIS dizopiramid flekainid lidokain (sistemski) meksiletin propafenon amjodaron bepridil dronedaron ivabradin kinidin ranolazin
English: Darunavir Krka 400 mg film-coated tablets Darunavir Krka 800 mg film-coated tablets darunavir
Slovenian: Darunavir Krka 400 mg filmsko obložene tablete Darunavir Krka 800 mg filmsko obložene tablete darunavir
English: darunavir/ ritonavir 800/100 mg once daily N=294
Slovenian: darunavir/ritonavir 800/100 mg enkrat na dan n = 294
English: Flurazepam Midazolam (parenteral) Zoldipem
Slovenian: POMIRJEVALA/USPAVALA buspirone klorazepat diazepam estazolam flurazepam midazolam (parenteralna oblika) zoldipem midazolam (peroralna oblika) triazolam
English: The rash is usually mild to moderate.
Slovenian: Izpuščaj je običajno blag do srednje hud.
English: If you notice within 12 hours, you must take the tablets immediately.
Slovenian: Če ste pozabili vzeti zdravilo Darunavir Krka Če to opazite v 12 urah, morate vzeti tablete takoj.
English: Recommended dose for treatment-experienced paediatric patients (3 to 17 years) with darunavir and ritonavir
Slovenian: Priporočeni odmerki darunavirja in ritonavirja a pri pediatričnih bolnikih, ki že imajo izkušnje z ART (starih 3 do 17 let)
English: 675 mg darunavir/100 mg ritonavir once daily
Slovenian: 675 mg darunavirja/100 mg ritonavirja enkrat na dan
English: Darunavir Krka 800 mg film-coated tablets:
Slovenian: Darunavir Krka 800 mg filmsko obložene tablete:
English: Concomitant use of salmeterol and darunavir co-administered with low dose ritonavir is not recommended.
Slovenian: Sočasna uporaba salmeterola in darunavirja skupaj z majhnim odmerkom ritonavirja ni priporočljiva.
English: Second trimester of pregnancy (n=12)
Slovenian: Drugo trimesečje nosečnosti (n = 12)
English: No special precautions or dose adjustments for darunavir/ritonavir are required in patients with renal impairment.
Slovenian: Pri bolnikih z okvaro ledvic posebna opozorila ali prilagoditve odmerjanja kombinacije zdravil darunavir/ritonavir niso potrebna.
English: Boosted darunavir must not be used concomitantly with products containing St John's wort (Hypericum perforatum) (see section 4.3).
Slovenian: Med jemanjem okrepljenega darunavirja se ne smejo uporabljati pripravki, ki vsebujejo šentjanževko (Hypericum perforatum) (glejte poglavje 4.3).
English: The Summary of Product Characteristics of ritonavir must, therefore, be consulted prior to initiation of therapy with darunavir.
Slovenian: Pred uvedbo terapije z darunavirjem morate zato prebrati tudi Povzetek glavnih značilnosti zdravila za ritonavir.
English: Postpartum (6-12 weeks) (n=12)
Slovenian: Obdobje po porodu (6-12 tednov) ( n = 12)
English: Digoxin 0.4 mg single dose digoxin AUC ↑ 61% digoxin Cmin ND digoxin Cmax ↑ 29% (↑ digoxin from probable inhibition of Pgp)
Slovenian: digoksin enkratni odmerek 0.4 mg digoksin AUC ↑ 61 % digoksin Cmin ND
English: HIV-1 RNA < 50 copies/ml CD4+ percent change from baseline CD4+ cell count mean change from baseline
Slovenian: HIV-1 RNK < 50 kopij/ml Sprememba št. celic CD4+ glede na začetno vrednost v odstotkih
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with darunavir coadministered with low dose ritonavir is required.
Slovenian: Če bolniki z normalno ledvično ali jetrno funkcijo potrebujejo zdravljenje z darunavirjem skupaj z majhnim odmerkom ritonavirja, je priporočljivo zmanjšati odmerek kolhicina ali prekiniti zdravljenje z njim.
English: Ethinylestradiol Norethindrone 35 μg/1 mg once daily
Slovenian: 35 µg/1 mg enkrat na dan
English: Purpose of the medicine
Slovenian: NAČIN IZDAJANJA ZDRAVILA
English: Please discuss with your doctor which dose is right for you.
Slovenian: O tem, kateri odmerek je primeren za vas, se pogovorite z zdravnikom.
English: This can be seen in a blood test. high blood pressure, flushing red or dry eyes fever, swelling of lower limbs due to fluids, malaise, irritability, pain symptoms of infection, herpes simplex erectile dysfunction, enlargement of breasts sleeping problems, sleepiness, depression, anxiety, abnormal dreams, decrease in sexual drive
Slovenian: To lahko pokaže krvni test. - visok krvni tlak, zardevanje - rdeče ali suhe oči - zvišana telesna temperatura, otekline spodnjih okončin zaradi tekočine,
English: Orangish brown, oval, biconvex film-coated tablets, engraved with a mark S2 on one side.
Slovenian: Oranžasto rjave, ovalne, izbočene filmsko obložene tablete z vtisnjeno oznako S2 na eni strani.
English: After therapy with darunavir has been initiated, patients should be advised not to alter the dosage, dose form or discontinue therapy without discussing with their health care provider.
Slovenian: Bolnike je treba poučiti, da med zdravljenjem brez predhodnega posveta z zdravnikom ne smejo spreminjati odmerka, farmacevtske oblike ali prekiniti zdravljenja.