FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Viekirax in one or more subsets of the paediatric populations in the treatment of chronic hepatitis C (see section 4.2 for information on paediatric use).
Croatian: Pedijatrijska populacija Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Viekirax u jednoj ili više podskupina pedijatrijske populacije u liječenju kroničnog hepatitisa C (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: In the presence of paritaprevir/ritonavir, dasabuvir exposures decreased by approximately 50% to 60% while ombitasvir exposures increased by 31-47%.
Croatian: U prisutnosti paritaprevira/ritonavira, izloženost dasabuviru smanjila se za oko 50 do 60%, dok se izloženost ombitasviru povećala za 31-47%.
English: Ombitasvir, paritaprevir and ritonavir are highly bound to plasma proteins.
Croatian: Ombitasvir, paritaprevir i ritonavir se u velikoj mjeri vežu za proteine u plazmi.
English: ANTIMYCOBACTERIALS Rifampicin
Croatian: ANTIMIKOBAKTERICI rifampicin
English: Multipack: 56 (4 packs of 14) film-coated tablets
Croatian: Višestruko pakiranje: 56 (4 pakiranja s 14) filmom obloženih tableta
English: • Less than 12 hours until your next dose - do not take the missed dose, take your next dose as usual with food.
Croatian: • manje od 12 sati do sljedeće doze - nemojte uzeti propuštenu dozu, a sljedeću dozu uzmite s hranom prema uobičajenom rasporedu.
English: Appropriate monitoring of serum digoxin levels is recommended.
Croatian: Preporučuje se odgovarajući nadzor razina digoksina u serumu.
English: These medicinal products may show clinically relevant increases in exposures of paritaprevir (e.g., ritonavir with atazanavir, erythromycin, diltiazem or verapamil).
Croatian: Ovi lijekovi mogu dovesti do klinički značajnog povećanja izloženosti paritapreviru (npr. primjena ritonavira s atazanavirom, eritromicinom, diltiazemom ili verapamilom).
English: Studies with ombitasvir and paritaprevir/ritonavir in animals have shown malformations (see section 5.3).
Croatian: Ispitivanja s ombitasvirom i paritaprevirom/ritonavirom na životinjama pokazala su pojavu malformacija (vidjeti dio 5.3).
English: salmeterol for asthma sildenafil when used to treat a heart and lung disorder called “pulmonary arterial hypertension”
Croatian: salmeterol za liječenje astme sildenafil kada se koristi za liječenje srčanog i plućnog poremećaja koji se zove „plućna arterijska hipertenzija“
English: ↑ losartan ↑ candesartan
Croatian: ↑ losartan ↑ kandesartan
English: Although buprenorphine and zolpidem are also metabolized by CYP3A, drug interaction studies indicate that no dose adjustment is needed when co-administering these medicinal products with Viekirax with or without dasabuvir (see Table 2).
Croatian: Iako se buprenorfin i zolpidem također metaboliziraju putem CYP3A, ispitivanja interakcija lijekova upućuju na to da nije potrebna prilagodba doze prilikom istodobne primjene ovih lijekova s lijekom Viekirax s dasabuvirom ili bez njega (vidjeti Tablicu 2).
English: The highest documented single dose administered to healthy volunteers was 400 mg for paritaprevir (with 100 mg ritonavir), 200 mg for ritonavir (with 100 mg paritaprevir) and 350 mg for ombitasvir.
Croatian: Najveća zabilježena pojedinačna doza primijenjena u zdravih dobrovoljaca iznosila je 400 mg za paritaprevir (uz 100 mg ritonavira), 200 mg za ritonavir (uz 100 mg paritaprevira) i 350 mg za ombitasvir.
English: Ritonavir did not exhibit a direct antiviral effect on the replication of HCV subgenomic replicons, and the presence of ritonavir did not affect the in vitro antiviral activity of paritaprevir.
Croatian: Ritonavir nije imao izravan antivirusni učinak na replikaciju subgenomskih replikona HCV-a niti je njegova prisutnost utjecala na antivirusnu aktivnost paritaprevira in vitro.
English: Routine monitoring of liver enzymes is not necessary in patients that do not have cirrhosis (for cirrhotics, see above).
Croatian: Nije potrebno rutinsko praćenje jetrenih enzima u bolesnika koji nemaju cirozu (za bolesnike s cirozom, vidjeti prethodno navedeno).
English: Total bilirubin >3-10 × ULN (grade 3) >10 × ULN (grade 4) *ULN: Upper limit of normal according to testing laboratory.
Croatian: Ukupni bilirubin >3-10 × GGN (3. stupanj) >10 × GGN (4. stupanj) *GGN: gornja granica normale prema laboratoriju u kojem je provedena pretraga
English: • itraconazole, ketoconazole, posaconazole, voriconazole
Croatian: • itrakonazol, ketokonazol, posakonazol, vorikonazol
English: Caution should be used when administering Viekirax with fluticasone or other glucocorticoids that are metabolised by CYP3A4.
Croatian: Potreban je oprez kada se Viekirax primjenjuje s flutikazonom ili drugim glukokortikoidima koji se metaboliziraju putem CYP3A4.
English: • apalutamide,enzalutamide
Croatian: • apalutamid, enzalutamid
English: These ALT elevations were significantly more frequent in the subgroup of subjects who were using ethinyloestradiol-containing medicinal products such as combined oral contraceptives or contraceptive vaginal rings (6 of 25 subjects); (see section 4.3).
Croatian: Ove povišene razine ALT-a značajno su češće primijećene u podskupini ispitanica koje su koristile lijekove koji sadrže etinilestradiol, poput kombiniranih oralnih kontraceptiva ili kontracepcijskih vaginalnih prstenova (6 od 25 ispitanica) (vidjeti dio 4.3).
English: • clarithromycin, telithromycin
Croatian: • klaritromicin, telitromicin
English: Ritonavir does not inhibit OAT1 and is not expected to inhibit OCT2, OAT3, MATE1 and MATE2K at clinically relevant concentrations.
Croatian: Ritonavir ne inhibira OAT1 i ne očekuje se da će inhibirati OCT2, OAT3, MATE1 i MATE2K pri klinički značajnim koncentracijama.
English: Lurasidone Pimozide Quetiapine
Croatian: ANTIPSIHOTICI lurasidon pimozid kvetiapin
English: PHOSPHODIESTERASE-(PDE-5) INHIBITORS Sildenafil (when used for treatment of pulmonary hypertension)
Croatian: INHIBITORI FOSFODIESTERAZE (PDE-5) sildenafil (kada se primjenjuje za liječenje plućne hipertenzije
English: Medicinal products transported by the OATP family and OCT1
Croatian: Lijekovi koji se prenose putem prijenosnika OATP skupine i OCT1
English: The major, inactive human metabolites of ombitasvir were not teratogenic in mice at exposures approximately 26 times higher than in humans at the recommended clinical dose.
Croatian: Glavni, neaktivni metaboliti ombitasvira u ljudi nisu bili teratogeni u miševa pri izloženostima približno 26 puta većima od one koja se postiže u ljudi nakon primjene preporučene kliničke doze.
English: Genotype 4
Croatian: Genotip 4
English: The effect on rilpivirine exposures was similar to that observed when rilpivirine was administered in the morning with food with Viekirax + dasabuvir (shown in the table above).
Croatian: Učinak na izloženost rilpivirinu bila je slična izloženosti zabilježenoj pri primjeni rilpivirina ujutro s hranom s lijekom Viekirax + dasabuvir (kao što je prikazano gore u tablici).
English: Available pharmacokinetic data in animals have shown excretion of active substance and metabolite in milk (see section 5.3).
Croatian: Dostupni farmakokinetički podaci iz istraživanja na životinjama pokazali su da se djelatna tvar i metaboliti izlučuju u mlijeko (vidjeti dio 5.3).
English: • oral midazolam, triazolam
Croatian: • oralni midazolam, triazolam
English: The recommended dose of atazanavir is 300 mg, without ritonavir, in combination with Viekirax with dasabuvir.
Croatian: Preporučena doza atazanavira je 300 mg bez ritonavira, u kombinaciji s lijekom Viekirax s dasabuvirom.
English: Treatment duration was 12 weeks for treatment naïve subjects, 12-24 weeks for treatment experienced subjects and 24 weeks for subjects with cirrhosis.
Croatian: Trajanje liječenja bilo je 12 tjedana za prethodno neliječene ispitanike, 12-24 tjedna za prethodno liječene ispitanike i 24 tjedna za ispitanike s cirozom.
English: Refer to the Summary of Product Characteristics of dasabuvir for its pharmacological properties.
Croatian: Vidjeti sažetak opisa svojstava lijeka za dasabuvir za njegova farmakološka svojstva.
English: The dose of ribavirin was left to the discretion of the investigator, with most subjects receiving 600 to 800 mg per day as a starting dose, and most subjects also receiving 600 to 800 mg per day at the end of treatment.
Croatian: Doza ribavirina prilagođavala se individualno prema odluci ispitivača, pri čemu je većina ispitanika primala dozu od 600 do 800 mg na dan kao početnu dozu, ali je većina ispitanika također primala dozu od 600 do 800 mg na dan i na kraju liječenja.
English: Nevirapine etravirine
Croatian: nevirapin etravirin
English: Examples of contraindicated strong or moderate enzyme inducers are provided below.
Croatian: Primjeri kontraindiciranih snažnih i umjerenih induktora enzima su navedeni u nastavku.
English: Ombitasvir Ombitasvir is an inhibitor of HCV NS5A which is essential for viral replication.
Croatian: Ombitasvir Ombitasvir inhibira protein NS5A HCV-a koji je neophodan za virusnu replikaciju.
English: Ombitasvir and its major inactive human metabolites (M29, M36) were not genotoxic in a battery of in vitro or in vivo assays, including bacterial mutagenicity, chromosome aberration using human peripheral blood lymphocytes and in vivo mouse micronucleus assays.
Croatian: Ombitasvir i njegovi glavni neaktivni metaboliti u ljudi (M29, M36) nisu bili genotoksični u nizu in vitro ili in vivo testova, uključujući test mutagenosti na bakterijama, test kromosomskih aberacija na limfocitima iz ljudske periferne krvi te in vivo mikronukleusni test na miševima.
English: Plasma protein binding is not meaningfully altered in subjects with renal or hepatic impairment.
Croatian: Vezanje za proteine u plazmi nije značajno izmijenjeno u ispitanika s oštećenjem funkcije bubrega ili jetre.
English: Pink, oblong, biconvex, film-coated tablets of dimensions 18.8 mm x 10.0 mm, debossed on one side with ‘AV1'.
Croatian: Ružičaste, duguljaste, bikonveksne, filmom obložene tablete dimenzija 18,8 mm x 10,0 mm, s otisnutom oznakom „AV1“ na jednoj strani.
English: The majority of these ALT elevations were transient and assessed as drug-related.
Croatian: Većinom je povišenje razine ALT-a bilo prolazno i ocijenjeno kao povezano s primjenom lijeka.
English: Extreme caution must be taken to avoid pregnancy in female patients and female partners of male patients when Viekirax is taken in combination with ribavirin.
Croatian: Moraju se poduzeti iznimne mjere opreza kako bi se izbjegla trudnoća u bolesnica i partnerica bolesnika muškoga spola kada se Viekirax primjenjuje u kombinaciji s ribavirinom.
English: Phenobarbital
Croatian: fenobarbital
English: Purpose of the medicine alfuzosin for an enlarged prostate amiodarone, disopyramide, dronedarone used to correct irregular heartbeats astemizole, terfenadine for allergy symptoms.
Croatian: Namjena lijeka alfuzosin za liječenje povećane prostate amiodaron, dizopiramid, dronedaron za korekciju nepravilnog srčanog ritma astemizol, terfenadin za liječenje simptoma alergije.
English: Examples of other CYP3A4 substrates which may require dose adjustment and/or clinical monitoring include calcium channel blockers (e.g. nifedipine), and trazodone.
Croatian: Primjeri ostalih CYP3A4 supstrata za koje je možda potrebna prilagodba doze i/ili kliničko praćenje uključuju blokatore kalcijevih kanala (npr. nifedipin) i trazodon.
English: ↑ lovastatin, simvastatin, atorvastatin
Croatian: Očekuje se: ↑ lovastatin, simvastatin, atorvastatin
English: Rilpivirine exposure is substantially increased (3-fold) when rilpivirine is given in combination with Viekirax and dasabuvir, with a consequent potential for QT-prolongation.
Croatian: Izloženost rilpivirinu značajno je povećana (3 puta) kada se rilpivirin primijenio u kombinaciji s lijekom Viekirax i dasabuvirom, uz posljedično moguće produljenje QT-intervala.
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati Viekirax Lijek čuvajte izvan pogleda i dohvata djece.
English: How to take Viekirax
Croatian: Kako uzimati Viekirax
English: Medicines you must tell your doctor about before taking Viekirax Medicine or active substance
Croatian: Lijekovi o kojima morate obavijestiti svog liječnika prije nego uzmete lijek Viekirax Lijek ili djelatna tvar
English: • Confirm if your treatment has worked and if you are free of the hepatitis C virus.
Croatian: • potvrdio da je liječenje bilo učinkovito i da u Vašem tijelu više nema virusa hepatitisa C
English: The long-term clinical impact of the emergence or persistence of virus containing Viekirax- and dasabuvir-resistance-associated substitutions on future treatment is unknown.
Croatian: Nije poznat dugoročan klinički utjecaj pojave ili postojanosti virusa koji sadrži supstitucije povezane s rezistencijom na Viekirax i dasabuvir na buduće liječenje.
English: Thus, for these medicinal products, results and dosing recommendations of the Viekirax and dasabuvir regimen can be extrapolated to Viekirax without dasabuvir.
Croatian: Stoga se za te lijekove rezultati i preporuke za doziranje kod režima liječenja lijekom Viekirax i dasabuvirom mogu ekstrapolirati na primjenu lijeka Viekirax bez dasabuvira.
English: For specific dosage instructions for dasabuvir and ribavirin, including dose modification, refer to the respective Summaries of Product Characteristics.
Croatian: Za specifične upute za doziranje dasabuvira i ribavirina, uključujući prilagođavanje doze, pročitajte odgovarajuće sažetke opisa svojstava lijeka.
English: Overall, 72 of 79 treatment-naive subjects (45 of 52 GT1a and 27 of 27 GT1b) and 40 of 45 treatment-experienced subjects (21 of 26 GT1a and 19 of 19 GT1b) achieved SVR12 after 12 weeks of treatment.
Croatian: Sveukupno, 72 od 79 prethodno neliječenih ispitanika (45 od 52 s genotipom 1a i 27 od 27 s genotipom 1b) i 40 od 45 prethodno liječenih ispitanika (21 od 26 s genotipom 1a i 19 od 19 s genotipom 1b) postiglo je SVR12 nakon 12
English: ANTIHYPERLIPIDAEMICS Gemfibrozil
Croatian: ANTIHIPERLIPEMICI gemfibrozil
English: Medicinal products metabolised by CYP2D6 or CYP1A2
Croatian: Lijekovi koji se metaboliziraju posredstvom CYP2D6 ili CYP1A2
English: The interactions between pitavastatin and fluvastatin and Viekirax have not been investigated.
Croatian: Interakcija između pitavastatina i fluvastatina i lijeka Viekirax nije ispitana.
English: − Tablet film-coating: poly(vinyl alcohol) (E 1203), macrogol (3350), talc (E 553b), titanium dioxide (E 171) and red iron oxide (E 172).
Croatian: Film ovojnica tablete: poli(vinilni alkohol) (E 1203), makrogol (3350), talk (E 553b), titanijev dioksid (E 171) i crveni željezov oksid (E 172).
English: ALT elevations were typically asymptomatic, generally occurred during the first 4 weeks of treatment (mean time 20 days, range 8-57 days) and most resolved with ongoing therapy.
Croatian: Povišene razine ALT-a su uglavnom bile asimptomatske te su se u pravilu pojavile tijekom prva 4 tjedna liječenja (srednje vrijeme 20 dana, raspon 8-57 dana), a uglavnom su se vratile na normalne vrijednosti uz nastavak liječenja.
English: Ombitasvir + paritaprevir + ritonavir* for 12 weeks Treatment-naïve
Croatian: Ombitasvir + paritaprevir + ritonavir* tijekom 12 tjedana
English: You should not breast-feed during treatment with Viekirax.
Croatian: Ne smijete dojiti tijekom liječenja lijekom Viekirax.
English: • Check for side effects of Viekirax or other antiviral medicines your doctor has prescribed for you to use with Viekirax (such as “dasabuvir” and “ribavirin”).
Croatian: • provjerio imate li nuspojave na lijek Viekirax ili druge antivirusne lijekove koje Vam je liječnik propisao uz lijek Viekirax (kao što su „dasabuvir“ i „ribavirin“).
English: In subjects receiving Viekirax and dasabuvir with ribavirin, the most commonly reported adverse reactions (greater than 20% of subjects) were fatigue and nausea.
Croatian: U ispitanika koji su primali lijekove Viekirax i dasabuvir s ribavirinom, najčešće prijavljivane nuspojave (prijavljene u više od 20% ispitanika) bile su umor i mučnina.
English: Changes in selected laboratory parameters are described in Table 4.
Croatian: Odstupanja u laboratorijskim vrijednostima Promjene odabranih laboratorijskih parametara opisane su u Tablici
English: Viekirax with or without dasabuvir was administered as multiple doses in all the drug interaction studies except the drug interaction studies with carbamazepine, gemfibrozil, ketoconazole, and sulfamethoxazole/trimethoprim..
Croatian: Viekirax s dasabuvirom ili bez njega bio je primijenjen kao višestruka doza u svim ispitivanjima interakcija osim u ispitivanjima interakcija s karbamazepinom, gemfibrozilom, ketokonazolom i sulfametoksazol/trimetoprimom.
English: ALT elevations were asymptomatic and generally occurred during the first 4 weeks of treatment, without concomitant elevations of bilirubin, and declined within approximately two weeks of onset with continued dosing of Viekirax and dasabuvir with or without ribavirin.
Croatian: Povišene razine ALT-a bile su asimptomatične i u pravilu su se pojavile tijekom prva 4 tjedna liječenja bez istodobnih povišenja razina bilirubina, te su se unutar približno 2 tjedna nakon pojave snizile uz kontinuiranu primjenu lijeka Viekirax i dasabuvira s ribavirinom ili bez njega.
English: HIV co-infected patients without suppressive antiretroviral therapy should not be treated with Viekirax.
Croatian: Bolesnici s istodobnom infekcijom HIV-om koji ne uzimaju supresivnu antiretrovirusnu terapiju ne smiju se liječiti lijekom Viekirax.
English: Paritaprevir and its hydrolysis product M13 were the predominant components observed in the milk of lactating rats, without effect on nursing pups.
Croatian: Paritaprevir i produkt njegove hidrolize M13 bili su najzastupljenije komponente primijećene u mlijeku štakora u laktaciji, ali nisu imali učinka na mladunčad koja je sisala.
English: If ribavirin is co-administered with Viekirax, the contraindications regarding use of ribavirin during pregnancy apply (see also the Summary of Product Characteristics of ribavirin).
Croatian: Ako se ribavirin primjenjuje istodobno s lijekom Viekirax, vrijede kontraindikacije koje se odnose na primjenu ribavirina tijekom trudnoće (vidjeti i sažetak opisa svojstava lijeka za ribavirin).
English: The following section describes the specific transporters and metabolizing enzymes that are affected by Viekirax with or without dasabuvir.
Croatian: Sljedeći dio opisuje specifične prijenosnike i metabolizirajuće enzime na koje Viekirax s dasabuvirom ili bez njega ima učinak.
English: No subjects experienced on-treatment virologic failure or relapse.
Croatian: U nijednog ispitanika nije zabilježen virološki neuspjeh tijekom liječenja ili relaps.
English: Paritaprevir is an inhibitor of HCV NS3/4A protease which is necessary for the proteolytic cleavage of the HCV encoded polyprotein (into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins) and is essential for viral replication.
Croatian: Paritaprevir je inhibitor NS3/4A proteaze HCV-a koja je potrebna za proteolitičko cijepanje poliproteina kojeg kodira HCV (u zrele oblike proteina NS3, NS4A, NS4B, NS5A i NS5B) i neophodna za virusnu replikaciju.
English: Tell your doctor or pharmacist if you notice any of the following side effects.
Croatian: Obratite se svom liječniku ili ljekarniku ako primijetite bilo koju od sljedećih nuspojava:
English: It is an antiviral medicine used to treat adults with chronic (long-term) hepatitis C (an infectious disease that affects the liver, caused by the hepatitis C virus).
Croatian: Viekirax je antivirusni lijek koji se koristi za liječenje odraslih koji boluju od kroničnog (dugotrajnog) hepatitisa C (zarazna bolest jetre koju izaziva virus hepatitisa C).
English: To maximise absorption, Viekirax tablets should be taken with food, without regard to fat and calorie content (see section 5.2).
Croatian: Kako bi se maksimizirala apsorpcija, Viekirax tablete treba uzimati s hranom, neovisno o sadržaju masti i kalorijskoj vrijednosti obroka (vidjeti dio 5.2).
English: The pharmacokinetics of Viekirax in paediatric patients has not been established (see section 4.2).
Croatian: Farmakokinetika lijeka Viekirax u pedijatrijskih ispitanika nije ustanovljena (vidjeti dio 4.2).
English: The activity of paritaprevir was attenuated 24 to 27 -fold in the presence of 40% human plasma.
Croatian: Aktivnost paritaprevira bilo je 24 do 27 puta slabije u prisutnosti 40% ljudske plazme.
English: HIV protease inhibitors other than atazanavir and darunavir (e.g., indinavir, saquinavir, tipranavir, lopinavir/ritonavir) are contraindicated (see section 4.3).
Croatian: Drugi inhibitori proteaze HIV-a, osim atazanavira i darunavira (npr. indinavir, sakvinavir, tipranavir, lopinavir/ritonavir) su kontraindicirani (vidjeti dio 4.3).
English: Coadministration of Viekirax with other antivirals has not been studied and, therefore, cannot be recommended.
Croatian: Istodobna primjena lijeka Viekirax s drugim antiviroticima nije ispitivana te se stoga ne može preporučiti.
English: Substitution L28V in HCV NS5A reduced the susceptibility to ombitasvir by 21-fold.
Croatian: Supstitucija L28V u proteinu NS5A HCV-a smanjila je osjetljivost na ombitasvir 21 puta.
English: Hydrocodone (as given in a fixed-dose hydrocodone/ paracetamol)
Croatian: hidrokodon (primijenjen kao fiksna kombinacija hidrokodon/ paracetamol
English: • amiodarone, disopyramide, dronedarone, quinidine, ranolazine
Croatian: • amiodaron, dizopiramid, dronedaron, kinidin, ranolazin
English: Patients should be informed that fatigue has been reported during treatment with Viekirax in combination with dasabuvir and ribavirin (see section 4.8).
Croatian: Bolesnike treba upozoriti da je tijekom liječenja lijekom Viekirax u kombinaciji s dasabuvirom i ribavirinom prijavljen umor (vidjeti dio 4.8).
English: Norethindrone (progestin only pill) 0.35 mg once daily
Croatian: ↓ dasabuvir noretindron (tableta koja sadrži samo progestin) 0,35 mg jedanput na dan
English: Summary of study design
Croatian: Sažetak dizajna ispitivanja
English: Therefore, Viekirax with or without dasabuvir is not expected to affect medicinal products which are primarily excreted by the renal route via these transporters (see section 5.2).
Croatian: Stoga se ne očekuje da će Viekirax primijenjen s dasabuvirom ili bez njega utjecati na lijekove koji se primarno izlučuju putem bubrega putem tih prijenosnika (vidjeti dio 5.2).
English: • astemizole, terfenadine
Croatian: • astemizol, terfenadin
English: Recommended co-administered medicinal product(s) and treatment duration for Viekirax by patient population
Croatian: Preporučeni lijek(ovi) za istodobnu primjenu i trajanje liječenja za lijek Viekirax prema skupinama bolesnika
English: ANGIOTENSIN RECEPTOR BLOCKER Valsartan
Croatian: BLOKATORI ANGIOTENZINSKIH RECEPTORA valsartan losartan kandesartan
English: The doses of paritaprevir were 100 mg and 200 mg and ombitasvir 25 mg.
Croatian: Primijenjene doze paritaprevira bile su 100 mg i 200 mg, a ombitasvira 25 mg.
English: Lopinavir/ritonavir 800/200 mg once daily (administered in the evening) was also administered with Viekirax with or without dasabuvir.
Croatian: Lopinavir/ritonavir 800/200 mg jedanput na dan (primijenjen navečer) je također primijenjen s lijekom Viekirax s dasabuvirom ili bez njega.
English: Clinical trial in patients receiving opioid substitution therapy
Croatian: Kliničko ispitivanje u bolesnika na zamjenskoj terapiji kod liječenja ovisnosti o opioidima
English: Paritaprevir is metabolised predominantly by CYP3A4 and to a lesser extent CYP3A5.
Croatian: Paritaprevir se prvenstveno metabolizira posredstvom CYP3A4, a u manjoj mjeri posredstvom CYP3A5.
English: Drug interactions need to be carefully taken into account in the setting of HIV co-infection (for details see section 4.5, Table 2).
Croatian: Interakcije lijekova moraju se pažljivo razmotriti kod bolesnika koji imaju istodobnu infekciju HIVom (za detalje vidjeti dio 4.5, Tablicu 2).