FrancophonIA/ELRC3.0 huggingface dataset:
English: Therefore, close monitoring of growth in children under imatinib treatment is recommended (see section
Danish: Derfor anbefales tæt monitorering af væksten hos børn, der er i behandling med imatinib (se pkt.
English: Following oral administration in healthy volunteers, the t½ was approximately 18 h, suggesting that oncedaily dosing is appropriate.
Danish: Efter oral administration til raske frivillige var t½ ca. 18 timer, hvilket indikerer, at dosering 1 gang daglig er passende.
English: • Unusual hair loss or thinning.
Danish: - Usædvanligt hårtab eller udtynding af håret.
English: • Unexpected bleeding or bruising (when you have not hurt yourself).
Danish: - Hvis du oplever uventede blødninger eller blå mærker (når du ikke er kommet til skade).
English: When the response rate is calculated from patients with at least one valid assessment, the response rate for CHR, CCyR and MR was 20/22 (90.9%), 9/9 (100%) and 11/17
Danish: Hvis responsraten beregnes ud fra patienter med mindst en valid parametervurdering, er reponsraten for CHR, CCyr og MR henholdsvis 20/22 (90,9%), 9/9 (100%) og
English: If tolerated, the dose can be increased for lack of efficacy (see
Danish: Hvis dosis tolereres, kan den øges ved manglede effekt (se pkt.
English: In CML, cytopenias, particularly neutropenia and thrombocytopenia, have been a consistent finding in all studies, with the suggestion of a higher frequency at high doses ≥ 750 mg (phase I study).
Danish: Cytopeni hos CML-patienter, særligt neutropeni og trombocytopeni, har været gennemgående fund i alle undersøgelser med tegn på større hyppighed ved doser ≥750 mg (fase I-undersøgelse).
English: Within each frequency grouping, undesirable effects are presented in order of frequency, the most frequent
Danish: Inden for hver enkelt frekvensgruppe er bivirkningerne opstillet efter frekvens med de hyppigste først.
English: In patients with GIST steady-state exposure was 1.5-fold higher than that observed for CML patients for the same dosage (400 mg daily).
Danish: Hos GIST-patienter var optagelsen ved steady-state 1,5 gange højere end den observeret hos CMLpatienter ved samme dosis (400 mg daglig).
English: The tablet is debossed with “IT” and “1” at each side of the score line.
Danish: Tabletten er præget med ”IT” og ”1” på hver side af delekærven.
English: In this study 147 patients were enrolled and randomised to receive either 400 mg or 600 mg orally once daily for up to 36 months.
Danish: I denne undersøgelse inkluderedes 147 patienter, der randomiseredes til enten 400 mg eller 600 mg oralt en gang daglig, i op til 36 måneder.
English: 3 Complete cytogenetic response confirmed by a second bone marrow cytogenetic evaluation performed at least one month after the initial bone marrow study
Danish: 3Fuldstændigt cytogenetisk respons bekræftet ved endnu en cytogenetisk knoglemarvsundersøgelse udført mindst 1 måned efter den initiale knoglemarvsundersøgelse.
English: The amount of Imatinib Teva B.V. given will depend on your child's condition, body weight and height.
Danish: Antallet af Imatinib Teva B.V.-kapsler afhænger af barnets tilstand, kropsvægt og højde.
English: Table 6 Summary of Z9001 trial RFS analyses by NIH and AFIP risk classifications
Danish: Tabel 6 Resumé af RFS-analyse for det kliniske forsøg Z9001 ved NIH og AFIP
English: - if you are allergic to imatinib or any of the other ingredients of this medicine (listed in section 6).
Danish: - hvis du er allergisk over for imatinib eller et af de øvrige indholdsstoffer i dette lægemiddel
English: In the event of overdose, the patient should be observed and appropriate supportive treatment given.
Danish: I tilfælde af overdosering bør patienten observeres, og der bør gives relevant understøttende
English: Frequency categories are defined using the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Danish: Frekvenskategorier er defineret ved brug af følgende konvention: Meget almindelig (≥1/10), almindelig (≥1/100 til <1/10), ikke almindelig (≥1/1.000 til <1/100), sjælden (≥1/10.000 til <1/1.000),
English: The majority of patients who achieved a CCyR developed the CCyR between months 3 and 10 with a median time to response based on the Kaplan-Meier estimate of 5.6 months.
Danish: Hovedparten af patienterne, som opnåede CCyR, udviklede dette mellem 3. og 10. måned med en mediantid til respons på 5,6 måneder
English: Based on the recovery of compound(s) after an oral 14C-labelled dose of imatinib, approximately 81% of the dose was recovered within 7 days in faeces (68% of dose) and urine (13% of dose).
Danish: Baseret på fremkomne stof(fer) efter oral dosis af 14C-mærket imatinib, genfandtes ca. 81% af dosis inden for 7 dage i fæces (68% af dosis) og urin (13% af dosis).
English: Median time to treatment failure in responders was 122 weeks (95% C.I 106-147), while in the overall study population it was 84 weeks (95% C.I 71-109).
Danish: Median tid til svigtende behandling hos respondenter var 122 uger (95% konfidensinterval 106-147), mens i den overordnede studiepopulation var 84 uger (95% konfidensinterval 71-109).
English: In the adjuvant setting, imatinib was investigated in a multicentre, double-blind, long-term, placebocontrolled phase III study (Z9001) involving 773 patients.
Danish: Som adjuverende behandling blev imatinib undersøgt i et multicenter, dobbeltblindet, længerevarende placebokontrolleret fase III klinisk forsøg (Z9001), der involverede 773 patienter.
English: After resection of primary GIST, patients were randomised to one of the two arms: imatinib at 400 mg/day or matching placebo for one year.
Danish: Efter resektion af primær GIST blev patienterne randomiseret til en af de to behandlingsarme: imatinib 400 mg/dag eller tilsvarende placebo i et år.
English: The safety and efficacy of imatinib in children with MDS/MPD, DFSP, GIST and HES/CEL aged less than 18 years of age have not been established in clinical trials.
Danish: Imatinibs sikkerhed og virkning hos børn under 18 år med MDS/MPD, DFSP, GIST og HES/CEL er ikke klarlagt i kliniske studier.
English: However if it is nearly time for the next dose, - Then continue with your normal schedule.
Danish: Men hvis det næsten er tid til at tage den næste dosis, skal du springe den glemte dosis over.
English: - If you are a woman who is pregnant or might get pregnant and are trying to open the capsules, you should handle the contents with caution in order to avoid skin-eye contact or inhalation.
Danish: - Hvis du er kvinde og er gravid eller planlægger at blive gravid, skal du være forsigtig, når du åbner kapslerne og håndterer indholdet for at undgå hud- og øjenkontakt eller indånding af pulveret.
English: One 3-year-old male exposed to a single dose of 400 mg experienced vomiting, diarrhoea and anorexia and another 3-year-old male exposed to a single dose of 980 mg experienced decreased white blood cell count
Danish: En 3-årig dreng, der fik en enkelt dosis på 400 mg, oplevede opkastning, diarré og appetitløshed, og en anden 3-årig dreng, der fik en enkelt dosis på 980 mg, oplevede nedsat antal hvide blodlegemer og
English: The effect of stopping treatment after the achievement of a complete cytogenetic response has not been
Danish: Effekt af seponering af behandling efter opnåelse af komplet cytogenetisk
English: Resume treatment with imatinib at 600 mg. 3.
Danish: Genoptag behandling med imatinib 600 mg. 3.
English: Because of known increased risks of bleeding in conjunction with the use of imatinib (e.g. haemorrhage), patients who require anticoagulation should receive low-molecular-weight or standard heparin, instead of coumarin derivatives such as warfarin.
Danish: På grund af den øgede risiko for blødning ved brug af imatinib (f.eks. hæmoragi) bør patienter med behov for antikoagulantia have lavmolekylært heparin eller standardheparin i stedet for
English: Caution should be used when taking imatinib with protease inhibitors, azole antifungals, certain macrolides
Danish: Der bør udvises forsigtighed, når imatinib tages sammen med proteasehæmmere, azol-antimykotika, visse makrolider (se pkt.
English: In patients with hypereosinophilic syndrome (HES) with occult infiltration of HES cells within the myocardium, isolated cases of cardiogenic shock/left ventricular dysfunction have been associated with HES cell degranulation upon the initiation of imatinib therapy.
Danish: Hos patienter med hypereosinofilt syndrom (HES) med skjult infiltration af HES-celler i myokardiet har der været isolerede tilfælde af kardiogent shock/dysfunktion af venstre ventrikel i forbindelse med HES-celledegranulering ved initiering af imatinibterapi.
English: The 23 patients enrolled in this registry received imatinib at a median daily dose of 264 mg (range: 100 to 400 mg) for a median duration of 7.2 years (range 0.1 to 12.7 years).
Danish: De 23 patienter, som var inkluderet i registerstudiet, fik imatinib med en daglig mediandosis på 264 mg (dosisområde: 100 til 400 mg) med en median varighed på 7,2 år (behandlingstid 0,1 til 12,7 år).
English: In two clinical studies (study B2222 and an intergroup study S0033) the daily dose of imatinib was escalated to 800 mg in patients progressing at the lower daily doses of 400 mg or 600 mg.
Danish: I to kliniske undersøgelser (studie B2222 og et mellemgruppe studie S0033) blev den daglige dosis af imatinib optrappet til 800 mg hos patienter, hvis sygdom fremskrider ved de lavere daglige doser på 400 mg eller 600 mg.
English: Ara-C: cytosine arabinoside; CP: cyclophosphamide; DEX: dexamethasone; MTX: methotrexate; 6MP: 6-mercaptopurine VM26: Teniposide; VCR: vincristine; IDA: idarubicine; i.v.
Danish: Ara-C: cytosin arabinosid; CP: cyclophosphamid; DEX: dexamethason; MTX: methotrexat; 6-MP: 6mercaptopurin; VM26: teniposid; VCR: vinkristin; IDA: idarubicin; i.v.
English: Detailed information on this medicine is available on the European Medicines Agency
Danish: Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs
English: Check whether cytopenia is related to leukaemia (marrow aspirate or biopsy).
Danish: Undersøg om cytopeni er relateret til leukæmi (marv-aspirant eller biopsi).
English: There is limited experience in children with Ph-positive ALL and very limited experience in children with MDS/MPD, DFSP, GIST and HES/CEL.
Danish: Der er begrænset erfaring hos børn og Ph-positiv ALL og meget begrænset erfaring med børn med MDS/MPD, DFSP, GIST og HEL/CEL.
English: Patients with cardiac disease, risk factors for cardiac failure or history of renal failure should be monitored carefully, and any patient with signs or symptoms consistent with cardiac or renal failure should be evaluated
Danish: Patienter med hjertesygdom, risikofaktorer for hjerteinsufficiens eller nyreinsufficiens i anamnesen skal monitoreres omhyggeligt, og alle patienter, som har symptomer forenelige med hjerte- eller nyreinsufficiens, bør undersøges og behandles.
English: Based on preliminary population pharmacokinetic analysis in GIST patients, there were three variables (albumin, WBC and bilirubin) found to have a statistically significant relationship with imatinib pharmacokinetics.
Danish: Ved præliminær populationsfarmakokinetikanalyse hos GIST-patienter fandtes 3 variable (albumin, leukocytter og bilirubin) at have statistisk signifikant indflydelse på imatinibs farmakokinetik.
English: The comparison of AUC(0-24) on day 8 and day 1 at the 340 mg/m2/day dose level revealed a 1.7-fold drug accumulation after repeated once-daily dosing.
Danish: Sammenligningen af AUC(0-24) på dag 8 og dag 1 ved 340 mg/m2/dag dosisniveauet viste en 1,7 gang højere lægemiddelakkumulering efter
English: This Ki value is far higher than the expected plasma levels of imatinib in patients; consequently no interaction is expected upon co-administration of either 5-fluorouracil or
Danish: Denne Ki værdi er langt højere end de forventede plasmaniveauer af imatinib hos patienter, og der forventes derfor ingen interaktion i forbindelse med samtidig administration af hverken 5-fluorouracil eller paclitaxel
English: Pretreatment with multiple doses of rifampicin 600 mg followed by a single 400 mg dose of imatinib resulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment.
Danish: Præbehandling med gentagne doser af rifampicin 600 mg efterfulgt af enkeltdosis imatinib 400 mg resulterede i fald i Cmax og AUC(0-∞) på mindst 54% og 7 4% af værdierne uden rifampicinbehandling.
English: • Swelling such as round your ankles or puffy eyes.
Danish: - Hævelse, som fx af anklerne eller omkring øjnene.
English: Musculoskeletal and connective tissue disorders Muscle spasm and cramps, musculoskeletal pain including myalgia9,
Danish: Muskelspasmer og kramper, muskuloskeletale smerter herunder myalgi9,
English: Posology for CML in children
Danish: Dosering ved CML hos børn
English: GIST is a cancer of the stomach and bowels.
Danish: GIST er en kræftform i mavesækken og tarmen.
English: The length of the capsule is from 23.0 mm to 23.6 mm and the width is 8.53 mm.
Danish: Kapslens længde er mellem 23,0 og 23,6 mm, og bredden er 8,53 mm.
English: SPECIAL STORAGE CONDITIONS Store below 30°C
Danish: SÆRLIGE OPBEVARINGSBETINGELSER Må ikke opbevares ved temperaturer over 30°C.
English: The length of the capsule is from 19.1 mm to 19.7 mm and the width is 6.91 mm.
Danish: Kapslens længde er mellem 19,1 og 19,7 mm, og bredden er 6,91 mm.
English: • Muscle spasms with a fever, red-brown urine, pain or weakness in your muscles (signs of muscle
Danish: - Muskelkramper med feber, rød-brun urin, smerter eller svaghed i dine muskler (tegn på
English: Paediatric accelerated phase CML and blast crisis (starting dose 340 mg/m2)
Danish: Børn med CML i accelereret fast og blastkrise (startdosis 340 mg/m2)
English: Cases of liver injury, including hepatic failure and hepatic necrosis, have been observed with imatinib.
Danish: Tilfælde af leverskade, inklusive leversvigt og levernekrose, er blevet observeret med imatinib.
English: Table 7 12-month and 36-month imatinib treatment (SSGXVIII/AIO Trial)
Danish: Tabel 7 12 måneders og 36 måneders imatinib-behandling (SSGXVIII/AIO forsøg)
English: The total daily dose in children must not exceed 800 mg with CML and 600 mg with Ph+ALL.
Danish: Den totale daglige dosis til børn må ikke overstige 800 mg for CML-patienter og 600 mg for Ph+ ALL-patienter.
English: • Chest pain, irregular heart rhythm (signs of heart problems).
Danish: - Brystsmerter, uregelmæssig hjerterytme (tegn på hjerteproblemer).
English: A large, international, open-label, non-controlled phase II study was conducted in patients with Philadelphia chromosome positive (Ph+) CML in blast crisis phase of the disease.
Danish: En stor, international, åben, ikke-kontrolleret fase II undersøgelse blev udført med patienter med Philadelphia-kromosom-positiv (Ph+) CML i blastkrisefase af sygdommen.
English: When needed, discontinuation of Imatinib Teva B.V. treatment may be considered.
Danish: Om nødvendigt kan det overvejes at ophøre med Imatinib Teva B.V.-behandling.
English: These reactions can usually be managed by withholding imatinib temporarily and with diuretics and other appropriate supportive care measures.
Danish: Disse tilfælde blev sædvanligvis behandlet ved midlertidigt at tilbageholde behandling med imatinib og behandle med diuretika og andre relevante, understøttende tiltag.
English: EU/1/17/1243/025 30 film-coated tablets EU/1/17/1243/026 30x1 film-coated tablets EU/1/17/1243/027 90 film-coated tablets EU/1/17/1243/028 90x1 film-coated tablets EU/1/17/1243/029 30 film-coated tablets EU/1/17/1243/030 30x1 film-coated tablets EU/1/17/1243/031 90 film-coated tablets EU/1/17/1243/032 90x1 film-coated tablets imatinib teva b.v. 400 mg film-coated tablets
Danish: EU/1/17/1243/025 30 filmovertrukne tabletter EU/1/17/1243/026 30x1 filmovertrukne tabletter EU/1/17/1243/027 90 filmovertrukne tabletter EU/1/17/1243/028 90x1 filmovertrukne tabletter EU/1/17/1243/029 30 filmovertrukne tabletter EU/1/17/1243/030 30x1 filmovertrukne tabletter EU/1/17/1243/031 90 filmovertrukne tabletter EU/1/17/1243/032 90x1 filmovertrukne tabletter
English: • Recurrence (reactivation) of hepatitis B infection when you have had hepatitis B in the past (a liver
Danish: - Genopblussen (reaktivering) af hepatitis B-infektion, hvis du tidligere har haft hepatitis B (leverbetændelse type B).
English: • The treatment of adult patients with unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery.
Danish: • behandling af voksne patienter med inoperabel dermatofibrosarkom protuberans (DFSP) og voksne patienter med residiverende og/eller metastaserende DFSP som ikke er tilgængelig for
English: There are no controlled trials in paediatric patients with c-Kit positive GIST.
Danish: Der er ingen kontrollerede forsøg med pædiatriske patienter med c-Kit-positiv GIST.
English: Limited data exist on the effect of dose increases from 400 mg to 600 mg or 800 mg in patients progressing at the lower dose (see section 5.1).
Danish: Der findes begrænsede data vedrørende effekt af dosisøgning fra 400 mg til 600 mg eller 800 mg hos patienter, der oplever bedring ved den lavere dosis (se pkt.
English: Total bilirubin: >3-10 ULN AST: any
Danish: Total-bilirubin: >3-10 ULN ASAT: alt
English: • Severely decreased urine output, feeling thirsty (signs of kidney problems).
Danish: - Kraftigt nedsat urinmængde, følelse af tørst (tegn på nyreproblemer).
English: The European Medicines Agency has waived the obligation to submit the results of studies with imatinib in all subsets of the paediatric population in Philadelphia chromosome (bcr-abl translocation)-positive chronic myeloid leukaemia (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med imatinib i alle undergrupper af den pædiatriske population med Philadelphia-kromosom (bcr-abl translokation)-positiv kronisk myeloid leukæmi (se pkt.
English: - If you are being treated for DFSP:
Danish: - Hvis du behandles for Ph-positiv ALL:
English: - If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby ask your doctor for advice before taking this medicine.
Danish: - Hvis du er gravid eller ammer, har mistanke om, at du er gravid, eller planlægger at blive gravid, skal du spørge din læge til råds, før du tager dette lægemiddel.
English: EU/1/17/1243/001 20x1 film-coated tablets EU/1/17/1243/002 60 film-coated tablets EU/1/17/1243/003 60x1 film-coated tablets EU/1/17/1243/004 120 film-coated tablets EU/1/17/1243/005 120x1 film-coated tablets EU/1/17/1243/006 180x1 film-coated tablets EU/1/17/1243/007 20x1 film-coated tablets EU/1/17/1243/008 60 film-coated tablets EU/1/17/1243/009 60x1 film-coated tablets EU/1/17/1243/010 120 film-coated tablets EU/1/17/1243/011 120x1 film-coated tablets EU/1/17/1243/012 180x1 film-coated tablets imatinib teva b.v. 100 mg film-coated tablets
Danish: EU/1/17/1243/001 20x1 filmovertrukne tabletter EU/1/17/1243/002 60 filmovertrukne tabletter EU/1/17/1243/003 60x1 filmovertrukne tabletter EU/1/17/1243/004 120 filmovertrukne tabletter EU/1/17/1243/005 120x1 filmovertrukne tabletter EU/1/17/1243/006 180x1 filmovertrukne tabletter EU/1/17/1243/007 20x1 filmovertrukne tabletter EU/1/17/1243/008 60 filmovertrukne tabletter EU/1/17/1243/009 60x1 filmovertrukne tabletter EU/1/17/1243/010 120 filmovertrukne tabletter EU/1/17/1243/011 120x1 filmovertrukne tabletter EU/1/17/1243/012 180x1 filmovertrukne tabletter
English: Immunohistochemistry was routinely performed with Kit antibody (A-4502, rabbit polyclonal antiserum, 1:100; DAKO Corporation, Carpinteria, CA) according to analysis by an avidin-biotin-peroxidase complex method after antigen retrieval.
Danish: Der udførtes rutinemæssigt immunohistokemi med Kit antistof (A-4502, polyklonalt kaninserum, 1:100; DAKO Corporation, Carpinteria, CA) i overensstemmelse med analyse ved avidin-biotinperoxidasekompleksmetode efter antigengenfinding.
English: In this study, 14 patients with HES/CEL were treated with 100 mg to 1,000 mg of imatinib daily.
Danish: I dette studie blev 14 patienter med HES/CEL behandlet med 100 mg-1.000 mg imatinib daglig.
English: Improvements were reported in cardiac, nervous, skin/subcutaneous tissue, respiratory/thoracic/mediastinal, musculoskeletal/connective tissue/vascular, and gastrointestinal organ systems.
Danish: Bedring blev rapporteret for: hjerte, nervesystem, hud/subkutant væv, respiratoriske/ thorakale/mediastinale, muskuloskeletale/bindevævs/kar og gastroentestinale organsystemer.
English: The free drug clearance of imatinib is probably similar between patients with renal impairment and those with normal renal function, since renal excretion represents only a minor elimination pathway for imatinib (see sections 4.2 and 4.4).
Danish: Udskilning af fri imatinib er sandsynligvis sammenlignelig for patienter med nedsat nyrefunktion og dem med normal nyrefunktion, eftersom udskillelse via nyren kun udgør en mindre elimineringsvej for imatinib (se pkt.
English: Due to the possible occurrence of tumour lysis syndrome (TLS), correction of clinically significant dehydration and treatment of high uric acid levels are recommended prior to initiation of imatinib (see
Danish: På grund af den mulige forekomst af tumorlysesyndrom (TLS) anbefales korrektion af klinisk signifikant dehydrering og behandling af forhøjede urinsyreniveauer før påbegyndelse af behandling med Imatinib Teva B.V.
English: In adult and paediatric patients, the effectiveness of imatinib is based on overall haematological and cytogenetic response rates and progression-free survival in CML, on haematological and cytogenetic response rates in Ph+ ALL, MDS/MPD, on haematological response rates in HES/CEL and on objective response rates in adult patients with unresectable and/or metastatic GIST and DFSP and on recurrence-free survival in adjuvant GIST.
Danish: Imatinibs effekt er hos voksne og børn baseret på generelle hæmatologiske og cytogene responsrater og progressionsfri overlevelse ved CML, på hæmatologiske og cytogenetiske responsrater ved Ph+ ALL, MDS/MPD, på hæmatologiske responsrater ved HES/CEL, på objektive responsrater hos voksne med inoperabel og/eller metastaserende GIST og DFSP samt på recidivfri overlevelse i adjuverende GIST.
English: Longer duration of the treatment (> 36 months) may delay the onset of further recurrences; however the impact of this finding on the overall survival remains unknown.
Danish: Længere behandlingsvarighed (>36 måneder) kan muligvis forsinke yderligere tilbagefald.
English: • Feeling sick (nausea), with loss of appetite, dark-coloured urine, yellow skin or eyes (signs of liver problems).
Danish: - Have kvalme med tab af appetitten, mørk urin, gul hud eller øjne (tegn på leverproblemer).
English: Some medicines can interfere with the effect of Imatinib Teva B.V. when taken together.
Danish: Nogle lægemidler kan påvirke virkningen af Imatinib Teva B.V., når de bruges samtidigt.
English: (0.5 h), days 7, 8, 14, 15;
Danish: (0,5 time), dag 7, 8, 14, 15; i.v.
English: • Pale skin, feeling tired and breathlessness and having dark urine (signs of low levels of red blood
Danish: - Bleghed, føle sig træt og stakåndet og have mørk urin (tegn på lavt antal røde blodceller).
English: • Paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of
Danish: • børn med nydiagnosticeret Philadelphia-kromosom (bcr-abl) positiv (Ph+) kronisk myeloid leukæmi (CML), for hvilke knoglemarvstransplantation ikke anses for førstevalgsbehandling.