FrancophonIA/ELRC3.0 huggingface dataset:
English: It is very important to talk to your doctor or pharmacist if you are taking any of the following:
Slovenian: Zelo pomembno je, da se posvetujete z zdravnikom ali farmacevtom, če jemljete kaj od naslednjega:
English: • Morning stiffness
Slovenian: • Jutranja okorelost
English: • Physical function (HAQ-DI)
Slovenian: • Telesno delovanje (HAQ-DI)
English: • throat and nose infections
Slovenian: • okužbe žrela in nosu
English: Most elevations > 5 x ULN were transient and did not require treatment discontinuation.
Slovenian: Večina zvišanj na > 5-krat nad ZNM je bila prehodnih in niso zahtevala prenehanja zdravljenja.
English: • Swallow the tablet whole with water.
Slovenian: • Tableto zaužijte celo z vodo.
English: • If you forget your dose for an entire day, just skip the missed dose and take only a single dose as usual the following day.
Slovenian: • Če odmerka niste vzeli že ves dan, preprosto preskočite izpuščeni odmerek in naslednji dan vzemite en sam odmerek, kot po navadi.
English: Upadacitinib is 52% bound to plasma proteins.
Slovenian: Upadacitinib je 52 % vezan na beljakovine v plazmi.
English: Durable response rates were observed (with or without MTX), with ACR20/50/70 responses maintained for at least 1 year.
Slovenian: Opažali so trajne deleže odziva (z MTX ali brez njega) in odzivi ACR20/50/70 so se ohranili vsaj 1 leto.
English: • Radiographic progression (mTSS)
Slovenian: • Radiografsko napredovanje (mTSS)
English: • if you are allergic to upadacitinib or any of the other ingredients of this medicine (listed in section 6)
Slovenian: • če ste alergični na upadacitinib ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Proportion of patients with no radiographic progressiond
Slovenian: Delež bolnikov brez radiografskega napredovanjad
English: 12 weeks after initiation of treatment and thereafter according to international clinical guidelines for hyperlipidaemia
Slovenian: 12 tednov po začetku zdravljenja, potem pa v skladu z mednarodnimi kliničnimi smernicami za hiperlipidemije.
English: RINVOQ is to be taken orally once daily with or without food and may be taken at any time of the day.
Slovenian: Zdravilo RINVOQ je treba jemati peroralno enkrat na dan, s hrano ali brez nje; bolnik ga lahko vzame kadar koli tekom dneva.
English: To listen to or request a copy of this leaflet in <Braille>, <large print> or <audio>, please contact the local representative of the Marketing Authorisation Holder.
Slovenian: Za poslušanje ali za izvod teh navodil v <Braillovi pisavi>, <velikem tisku> ali <avdio-obliki> se obrnite na lokalnega predstavnika imetnika dovoljenja za promet z zdravilom.
English: • if you have a severe infection (such as pneumonia or bacterial skin infection)
Slovenian: • če imate kakšno hudo okužbo (na primer pljučnico ali bakterijsko okužbo kože).
English: Elevations were observed at 2 to 4 weeks of treatment and remained stable with longer-term treatment.
Slovenian: Zvišanja so opažali po 2 do 4 tednih zdravljenja in so med dolgotrajnim zdravljenjem ostala stabilna.
English: The safety and efficacy of RINVOQ in children and adolescents aged 0 to less than 18 years have not yet been established.
Slovenian: Varnost in učinkovitost zdravila RINVOQ pri otrocih in mladostnikih, mlajših od 18 let, še nista ugotovljeni.
English: UPA 15mg N 314 317 216 217 221 221 651 651 327 169 164 Week
Slovenian: UPA 15 mg N 314 317 216 217 221 221 651 651 327 169 164 Teden
English: Mean neutrophil counts decreased over 4 to 8 weeks.
Slovenian: Povprečno število nevtrofilcev se je zmanjšalo v 4 do 8 tednih.
English: The tests are to check that treatment with RINVOQ is not causing problems.
Slovenian: Namen teh preiskav je preveriti, da vam zdravljenje z zdravilom RINVOQ ne povzroča težav.
English: The pattern and incidence of elevation in ALT/AST remained stable over time including in long term extension studies.
Slovenian: Vzorec in pojavnost zvišanj ALT/AST sta ostala stabilna skozi čas, vključno z dolgotrajnimi podaljšanimi študijami.
English: The frequency of adverse reactions listed below is defined using the following convention: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100).
Slovenian: Pogostnost spodaj naštetih neželenih učinkov je opredeljena po naslednjem dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do 1/100).
English: 8017 JV Zwolle NETHERLANDS
Slovenian: 8017 JV Zwolle Nizozemska
English: The following list of adverse reactions is based on experience from registrational clinical studies.
Slovenian: Spodnja preglednica neželenih učinkov temelji na izkušnjah iz registracijskih kliničnih študij.
English: The effect of upadacitinib on human fertility has not been evaluated.
Slovenian: Vpliva upadacitiniba na plodnost pri človeku niso ovrednotili.
English: Do not use this medicine after the expiry date which is stated on the blister label and carton after ‘EXP'.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu nalepki in na škatli poleg oznake "EXP".
English: Zwolle, 8017 JV, Netherlands
Slovenian: Zwolle, 8017 JV, Nizozemska
English: Tablets should be swallowed whole and should not be split, crushed, or chewed.
Slovenian: Tablete mora zaužiti cele in jih ne sme lomiti, drobiti ali žvečiti.
English: The rate of serious infections remained stable with long-term exposure.
Slovenian: Delež resnih okužb je ostal med dolgotrajno izpostavljenostjo stabilen.
English: • with chronic or recurrent infection
Slovenian: • s kronično ali ponavljajočo se okužbo,
English: You and your doctor should decide if you will breast-feed or use RINVOQ.
Slovenian: Vi in vaš zdravnik morata odločiti, ali boste dojili ali jemali zdravilo RINVOQ.
English: Upadacitinib mean terminal elimination half-life ranged from 9 to 14 hours.
Slovenian: Povprečni terminalni eliminacijski razpolovni čas upadacitiniba je segal od 9 do 14 ur.
English: Each calendar blister contains 7 tablets.
Slovenian: En koledarski pretisni omot vsebuje 7 tablet.
English: It belongs to a group of medicines called Janus kinase inhibitors, which help reduce inflammation.
Slovenian: Ta spada v skupino zdravil, imenovanih zaviralci Janusove kinaze, ki pomagajo zmanjšati vnetje.
English: Upadacitinib was not carcinogenic in a 26-week carcinogenicity study in CByB6F1-Tg(HRAS)2Jic transgenic mice.
Slovenian: Upadacitinib ni bil kancerogen v 26-tedenski študiji kancerogenosti pri CByB6F1-Tg (HRAS)2Jic transgenih miših.
English: Intrinsic factors
Slovenian: Intrinzični dejavniki
English: • you have heart problems, high blood pressure, or high cholesterol
Slovenian: • če imate težave s srcem, visok krvni tlak ali povišano raven holesterola v krvi.
English: The MAH shall ensure that in each Member State where RINVOQ is marketed, all healthcare professionals and patients/carers who are expected to prescribe, dispense or use RINVOQ have access to/are provided with the following educational package:
Slovenian: Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da bodo v vseh državah članicah, kjer je zdravilo RINVOQ na trgu, vsi zdravstveni delavci in bolniki/skrbniki, za katere se pričakuje, da bodo predpisovali, izdajali ali uporabljali zdravilo RINVOQ, imeli dostop do/prejeli naslednji paket izobraževalnih gradiv:
English: Upadacitinib partitions similarly between plasma and blood cellular components, as indicated by the blood to plasma ratio of 1.0.
Slovenian: Upadacitinib se med plazmo in krvnimi celičnimi komponentami porazdeli podobno; to se kaže z razmerjem med krvjo in plazmo 1,0.
English: Upadacitinib should not be initiated in patients with an active, serious infection, including localised infections.
Slovenian: Upadacitiniba se ne sme uvesti bolnikom, ki imajo kakšno aktivno, resno okužbo, vključno z lokaliziranimi okužbami.
English: • Active tuberculosis (TB) or active serious infections (see section 4.4).
Slovenian: • Aktivna tuberkuloza (TB) ali aktivne resne okužbe (glejte poglavje 4.4).
English: The effect of these lipid parameter elevations on cardiovascular morbidity and mortality has not been determined (see section 4.2 for monitoring guidance).
Slovenian: Vpliv teh zvišanj lipidov na srčno-žilno obolevnost in umrljivost ni ugotovljen (glejte poglavje 4.2 za smernice za nadzor).
English: As there is a higher incidence of infections in the elderly ≥ 75 years of age, caution should be used when treating this population.
Slovenian: Ker je pri osebah, starih ≥ 75 let, incidenca okužb višja, je pri zdravljenju te populacije potrebna previdnost.
English: • Instructions for how to access digital HCP information
Slovenian: • Navodila o tem, kako dostopati do digitalnih informacij za zdravstvene delavce.
English: Patients should be managed according to international clinical guidelines for hyperlipidaemia
Slovenian: Bolnike je treba voditi v skladu z mednarodnimi kliničnimi smernicami za hiperlipidemijo.
English: Talk to your doctor if you develop a new lesion or any change in the appearance of an area on the skin.
Slovenian: Posvetujte se z zdravnikom, če se vam pojavi kakšna nova sprememba na koži ali če se spremeni videz določenega predela na koži.
English: In case of an overdose, it is recommended that the patient be monitored for signs and symptoms of adverse reactions.
Slovenian: V primeru prevelikega odmerjanja je bolnika priporočljivo nadzorovati glede znakov in simptomov neželenih učinkov.
English: The efficacy and safety of upadacitinib 15 mg once daily was assessed in five Phase 3 randomised, double-blind, multicentre studies in patients with moderately to severely active rheumatoid arthritis and fulfilling the ACR/EULAR 2010 classification criteria (see Table 3).
Slovenian: Učinkovitost in varnost 15 mg upadacitiniba enkrat na dan so ocenili v petih randomiziranih, dvojno slepih, multicentričnih študijah 3. faze pri bolnikih z zmernim do hudim aktivnim revmatoidnim artritisom, ki so izpolnjevali klasifikacijska merila ACR/EULAR 2010 (glejte preglednico 3).
English: Note: Week 48-data derived from analysis on Full Analysis set (FAS) by randomised group using NonResponder Imputation
Slovenian: Opomba: Podatki v 48. tednu so pridobljeni iz analize niza celotne analize (FAS = Full Analysis set) z randomizirano skupino z uporabo imputacije podatkov bolnikov, ki se niso odzvali
English: Consultation with a physician with expertise in the treatment of TB is recommended to aid in the decision about whether initiating anti-TB therapy is appropriate for an individual patient.
Slovenian: Priporočljiv je posvet z zdravnikom, izkušenim na področju zdravljenja TB, kot pomoč pri odločitvi o tem, ali je za posameznega bolnika primerna uvedba protituberkuloznega zdravljenja.
English: Age, sex, body weight, race, and ethnicity did not have a clinically meaningful effect on upadacitinib exposure.
Slovenian: Starost, spol, telesna masa, rasa in etnična pripadnost niso klinično pomembno vplivali na izpostavljenost upadacitinibu.
English: Monitoring guidance
Slovenian: Smernice za nadzor
English: You may get some of the side effects listed in section 4.
Slovenian: Pojavijo se vam lahko nekateri neželeni učinki, navedeni v poglavju 4.
English: How to open the bottle
Slovenian: Kako odprete plastenko
English: How to puncture the foil
Slovenian: Kako predrete folijo
English: Prior to initiating upadacitinib, it is recommended that patients be brought up to date with all immunisations, including prophylactic zoster vaccinations, in agreement with current immunisation guidelines.
Slovenian: Pred uvedbo upadacitiniba je priporočljivo poskrbeti, da imajo bolniki opravljena vsa cepljenja, vključno s profilaktičnim cepljenjem proti zostru, v skladu z veljavnimi smernicami za cepljenja.
English: • you have had a herpes zoster infection (shingles), because RINVOQ may allow it to come back.
Slovenian: • če ste imeli okužbo s herpesom zostrom (pasovcem), kajti zdravilo RINVOQ lahko omogoči njegovo ponovitev.
English: RINVOQ works by reducing the activity of an enzyme in the body called ‘Janus kinase'.
Slovenian: Zdravilo RINVOQ deluje tako, da v telesu zmanjša aktivnost encima, imenovanega "Janusova kinaza".
English: There was a higher rate of serious infections in patients ≥ 75 years of age, although data are limited.
Slovenian: Delež resnih okužb je bil večji pri bolnikih, starih ≥ 75 let, toda podatkov je malo.
English: Upadacitinib therapy may be resumed once the infection is controlled.
Slovenian: Zdravljenje z upadacitinibom je mogoče znova začeti, ko je okužba obvladana.
English: In a pre-/postnatal development study in rats, there were no maternal effects, no effects on parturition, lactation or maternal behaviour and no effects on their offspring.
Slovenian: V študiji pred in ponatalnega razvoja pri podganah ni bilo učinkov na samice-matere, ni bilo učinkov na skotitev, dojenje ali vedenje mater in tudi ni bilo učinkov na njihovo potomstvo.
English: Analyses of erosion and joint space narrowing scores were consistent with the overall scores.
Slovenian: Analize rezultatov erozij in zožitve sklepnih špranj so bile konsistentne s splošnimi rezultati.
English: The recommended dose is one 15 mg tablet once a day.
Slovenian: Priporočeni odmerek je ena 15-mg tableta enkrat na dan.
English: This phosphorylation, in turn, modulates gene expression and cellular function.
Slovenian: Fosforilacija nato modulira izražanje genov in celično delovanje.
English: You should not use RINVOQ while breast-feeding as it is not known if this medicine passes into breast milk.
Slovenian: V obdobju dojenja ne smete uporabljati zdravila RINVOQ, ker ni znano, ali to zdravilo prehaja v materino mleko.
English: A decision must be made whether to discontinue breast-feeding or to discontinue upadacitinib therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba bodisi za prenehanje dojenja bodisi za prenehanje zdravljenja z upadacitinibom, upoštevaje koristi dojenja za otroka in koristi zdravljenja za žensko.
English: Upadacitinib has no relevant effects on plasma exposures of ethinylestradiol, levonorgestrel, methotrexate, or medicinal products that are substrates for metabolism by CYP1A2, CYP2B6, CYP2C9, CYP2C19, or CYP2D6.
Slovenian: Upadacitinib ne vpliva pomembno na plazemsko izpostavljenost etinilestradiolu, levonorgestrelu, metotreksatu ali zdravilom, ki so substrati za presnovo s CYP1A2, CYP2B6, CYP2C9, CYP2C19 ali CYP2D6.
English: Prior to launch of RINVOQ in each Member State the Marketing Authorisation Holder (MAH) must agree about the content and format of the educational programme, including communication media, distribution modalities, and any other aspects of the programme, with the National Competent Authority.
Slovenian: Pred prihodom zdravila RINVOQ na trg v posamezni državi članici se mora imetnik dovoljenja za promet z zdravilom s pristojnim nacionalnim organom dogovoriti o vsebini in obliki izobraževalnega programa, vključno s sredstvi obveščanja, načini razdeljevanja in morebitnimi drugimi vidiki programa.
English: By reducing the activity of this enzyme, RINVOQ can help to reduce pain, stiffness and swelling in your joints, reduce tiredness and it can slow down damage to the bone and cartilage in your joints.
Slovenian: Z zmanjšanjem aktivnosti tega encima lahko zdravilo RINVOQ pomaga zmanjšati bolečine, okorelost in oteklost sklepov in zmanjšati utrujenost, lahko pa tudi pomaga upočasniti okvaro kosti in hrustanca v sklepih.
English: Creatine phosphokinase
Slovenian: Kreatin-fosfokinaza
English: Do not split, crush, chew or break the tablet before swallowing as it may change how much medicine gets into your body.
Slovenian: Preden tableto zaužijete, je ne smete razdeliti, zdrobiti, zgristi ali prelomiti: to namreč lahko vpliva na to, koliko zdravila vstopi v vaše telo.
English: Push down to make a hole in the foil and move the cutting tool round the edge of the foil to continue cutting the foil.
Slovenian: Potisnite navzdol, da boste naredili luknjo v folijo in pomikajte pripomoček za rezanje okrog roba folije, da jo boste še naprej prerezali.
English: Like all medicines, RINVOQ can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo RINVOQ neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Following single dose administration of [14C]-upadacitinib immediate-release solution, upadacitinib was eliminated predominantly as the unchanged parent substance in urine (24%) and faeces (38%).
Slovenian: Po enkratnem odmerku raztopine [14C]-upadacitiniba s takojšnim sproščanjem se je upadacitinib pretežno izločil kot nespremenjena matična snov v urinu (24 %) in blatu (38 %).
English: • Low disease activity (CDAI)
Slovenian: • Nizka aktivnost bolezni (CDAI)
English: In vitro, upadacitinib is a substrate for the efflux transporters P-gp and BCRP.
Slovenian: In vitro je upadacitinib substrat iztočnih prenašalcev P-gp in BCRP.
English: Immunomodulatory medicinal products may increase the risk of malignancies, including lymphoma.
Slovenian: Imunomodulirajoča zdravila lahko povečajo tveganje za maligne bolezni, vključno z limfomi.
English: Week 24e/26f
Slovenian: Teden 24e/26f
English: The European Medicines Agency has deferred the obligation to submit the results of studies with RINVOQ in one or more subsets of the paediatric population in chronic idiopathic arthritis (including rheumatoid arthritis, psoriatic arthritis, spondyloarthritis and juvenile idiopathic arthritis) (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom RINVOQ za eno ali več podskupin pediatrične populacije s kroničnim idiopatskim artritisom (vključno z revmatoidnim artritisom, psoriatičnim artritisom, spondiloartritisom in juvenilnim idiopatskim artritisom) (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Upadacitinib is a selective and reversible JAK inhibitor.
Slovenian: Upadacitinib je selektiven in reverzibilen zaviralec JAK.
English: Patients treated with upadacitinib should have risk factors (e.g., hypertension, hyperlipidaemia) managed as part of usual standard of care.
Slovenian: Pri bolnikih, ki se zdravijo z upadacitinibom, je treba dejavnike tveganja (npr. hipertenzijo, hiperlipidemijo) obravnavati kot del standardne oskrbe.
English: When you have taken your tablet, put the cap back on and close the bottle.
Slovenian: Ko imate tableto, namestite pokrovček nazaj in plastenko zaprite.
English: Mean CPK values increased by 4 weeks with a mean increase of 60 U/L at 12 weeks and then remained stable at an increased value thereafter including with extended therapy.
Slovenian: Povprečne vrednosti CPK so se zvišale do 4 tednov; povprečno zvišanje je bilo 60 e/l po 12 tednih in je nato ostalo stabilno na zvišani vrednosti, vključno s podaljšanim zdravljenjem.
English: Dose related increases in foetal resorptions associated with post-implantation losses at 25 and 75 mg/kg/day in this study in rats were attributed to the developmental/teratogenic effects of upadacitinib.
Slovenian: Z odmerkom povezana povečanja resorpcij plodov, ki so bila povezana s poimplantacijskimi izgubami ob odmerkih 25 in 75 mg/kg/dan v tej študiji na podganah, so pripisali razvojnim/teratogenim učinkom upadacitiniba.
English: • you have cancer - because your doctor will have to decide if you can still be given RINVOQ
Slovenian: • če imate raka - zdravnik bo namreč moral odločiti, ali lahko kljub temu prejemate zdravilo
English: Talk to your doctor or get medical help straight away if you get any signs of infection such as:
Slovenian: Resni neželeni učinki Takoj se posvetujte z zdravnikom ali poiščite zdravniško pomoč, če se vam pojavijo kakšni znaki okužbe, na primer:
English: Overall, both low disease activity and clinical remission rates were consistent across patient populations, with or without MTX.
Slovenian: V celoti sta bila tako delež nizke aktivnosti kot delež klinične remisije med populacijami dosledna tako z MTX kot brez njega.
English: • with underlying conditions that may predispose them to infection.
Slovenian: • z osnovnimi boleznimi, ki lahko povečajo nagnjenost k okužbam.
English: If a patient becomes pregnant while taking upadacitinib the parents should be informed of the potential risk to the foetus.
Slovenian: Če bolnica med jemanjem upadacitiniba zanosi, je treba starše seznaniti z možnim tveganjem za plod.
English: RINVOQ is used to treat adults with rheumatoid arthritis.
Slovenian: Zdravilo RINVOQ se uporablja za zdravljenje odraslih oseb z revmatoidnim artritisom.
English: The brochure also informs on steps which can be taken to reduce a patient's risk for key safety aspects of upadacitinib.
Slovenian: Vodnik seznanja tudi z ukrepi, ki jih je mogoče uporabiti za zmanjševanje ključnih varnostnih tveganj pri uporabi upadacitiniba.
English: Treatment should be interrupted if a patient develops a serious infection until the infection is controlled.
Slovenian: Zdravljenje je treba prekiniti, če se bolniku pojavi kakšna resna okužba, in sicer za čas, dokler okužba ni obvladana.
English: Janus Kinases (JAKs) are intracellular enzymes that transmit cytokine or growth factor signals involved in a broad range of cellular processes including inflammatory responses, hematopoiesis and immune surveillance.
Slovenian: Janusove kinaze (JAK) so znotrajcelični encimi, ki prenašajo signale citokinov ali rastnih faktorjev, vključene v širok nabor celičnih procesov, vključno z vnetnim odzivom, hematopoezo in imunskim nadzorom.
English: Tablet contents:
Slovenian: Vsebina tablete:
English: Treatment with upadacitinib should be initiated and supervised by physicians experienced in the diagnosis and treatment of rheumatoid arthritis.
Slovenian: Zdravljenje z upadacitinibom morajo uvesti in nadzorovati zdravniki, ki imajo izkušnje z diagnosticiranjem in zdravljenjem revmatoidnega artritisa.
English: Multipack: 84 (3 packs of 28) prolonged-release tablets
Slovenian: Multipakiranje: 84 (3 pakiranja po 28) tablet s podaljšanim sproščanjem
English: Tell your doctor if you get a painful swollen leg, chest pain, or shortness of breath as these can be signs of blood clots in the veins.
Slovenian: Zdravnika morate obvestiti, če se vam pojavijo boleča oteklost noge, bolečine v prsih ali težko dihanje, kajti to so lahko znaki krvnih strdkov v venah.
English: If you take more RINVOQ than you should, contact your doctor.
Slovenian: Če ste vzeli večji odmerek zdravila RINVOQ, kot bi smeli, se posvetujte z zdravnikom.
English: Approximately 90% of upadacitinib in the systemic circulation is eliminated within 24 hours of dosing (within the range of doses evaluated in clinical studies).
Slovenian: Približno 90 % upadacitiniba v sistemskem obtoku se odstrani v 24 urah po uporabi (v okviru odmerkov,
English: What RINVOQ is and what it is used for 2.
Slovenian: Kaj je zdravilo RINVOQ in za kaj ga uporabljamo 2.
English: Coadministration of upadacitinib with a high-fat meal had no clinically relevant effect on upadacitinib exposures (increased AUC by 29% and Cmax by 39%).
Slovenian: Sočasna uporaba upadacitiniba z zelo mastnim obrokom ni klinično pomembno vplivala na izpostavljenost upadacitinibu (povečanje AUC za 29 % in Cmax za 39 %).
English: The presence of at least 6 tender and 6 swollen joints and evidence of systemic inflammation based on elevation of hsCRP was required at baseline.
Slovenian: Izhodiščno je bila zahtevana prisotnost vsaj 6 bolečih in 6 oteklih sklepov in znaki sistemskega vnetja na podlagi zvišanja hsCRP.
English: JAK1 is important in inflammatory cytokine signals while JAK2 is important for red blood cell maturation and JAK3 signals play a role in immune surveillance and lymphocyte function.
Slovenian: JAK1 je pomembna pri vnetnih citokinskih signalih, JAK2 za dozorevanje eritrocitov, JAK3 pa ima vlogo pri imunskem nadzoru in delovanju limfocitov.