FrancophonIA/ELRC3.0 huggingface dataset:
English: Caution should be taken when using anagrelide in patients with known risk factors for prolongation of the QT interval, such as congenital long QT syndrome, a known history of acquired QTc prolongation,
Slovenian: Kadar uporabljamo anagrelid pri bolnikih z znanimi dejavniki tveganja za podaljšanje intervala QT, na primer s prirojenim sindromom dolgega intervala QT, z znano anamnezo pridobljenega podaljšanja intervala QTc, pri uporabi zdravil, ki lahko podaljšajo interval QTc, in pri hipokaliemiji, je potrebna previdnost.
English: • If you have any problems with your liver or kidneys.
Slovenian: • če imate težave z delovanjem jeter ali ledvic.
English: The lowest dose in males (3 mg/kg/day) corresponds to 37 times the human AUC exposure after a 1 mg twice daily dose.
Slovenian: Najmanjši odmerek pri samcih (3 mg/kg/dan) je enak 37-kratniku AUC pri ljudeh pri odmerjenju 1 mg dvakrat dnevno.
English: Cardiac disorders
Slovenian: Kardiovaskularni sistem
English: Tell your doctor if you are pregnant or are planning to become pregnant.
Slovenian: Povejte zdravniku, če dojite ali če nameravate začeti dojiti.
English: • If you have moderate or severe liver problems;
Slovenian: • če imate zmerne ali hude težave z delovanjem jeter;
English: A capsule size 4 (approximately 14.3 x 5.3 mm) with an opaque white body and cap.
Slovenian: Kapsula velikosti št. 4 (približno 14,3 x 5,3 mm)z neprozornim belim telesom in pokrovčkom.
English: Anagrelide Mylan should not be taken by pregnant women.
Slovenian: Zdravila Anagrelid Mylan nosečnice ne smejo jemati.
English: How to store Anagrelide Mylan Contents of the pack and other information
Slovenian: Shranjevanje zdravila Anagrelid Mylan Vsebina pakiranja in dodatne informacije
English: Marketing Authorisation Holder Mylan S.A.S
Slovenian: Imetnik dovoljenja za promet z zdravilom Mylan S.A.S
English: However, hepatic metabolism represents the major route of anagrelide clearance and liver function may therefore be expected to influence this process.
Slovenian: Vendar predstavlja jetrna presnova glavno pot, po kateri se razgrajuje anagrelid in tako morda delovanje jeter vpliva na presnovo anagrelida.
English: Anagrelide Mylan contains less than 1 mmol sodium (23 mg) per capsule, that is to say essentially ‘sodium-free'.
Slovenian: Zdravilo Anagrelid Mylan vsebuje natrij To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na kapsulo, kar v bistvu pomeni ‘brez natrija'.
English: The mean recovery of 2-amino-5, 6-dichloro-3, 4-dihydroquinazoline in urine is approximately 18-35% of the administered dose.
Slovenian: V urinu se izloči povprečno približno 18-35 % danega odmerka v obliki 2-amino-5,6-dikloro-3, 4-dihidrokinazolina.
English: The other ingredients are lactose (see section 2 ‘Anagrelide Mylan contains lactose'), croscarmellose sodium, povidone, microcrystalline cellulose, magnesium stearate, gelatin and titanium dioxide(E171).
Slovenian: Druge sestavine zdravila so laktoza (glejte poglavje 2 „Zdravilo Anagrelid Mylan vsebuje laktozo“), premreženi natrijev karmelozat, povidon, mikrokristalna celuloza, magnezijev stearat, želatina in titanov dioksid (E171).
English: The other ingredients are lactose (see section 2 ‘Anagrelide Mylan contains lactose'), croscarmellose sodium, povidone, microcrystalline cellulose, magnesium stearate, gelatin, titanium dioxide (E171) and iron oxide black (E172).
Slovenian: Druge sestavine zdravila so laktoza (glejte poglavje 2 „Zdravilo Anagrelid Mylan vsebuje laktozo“), premreženi natrijev karmelozat, povidon, mikrokristalna celuloza, magnezijev stearat, želatina, titanov dioksid (E171) in črni železov oksid (E172).
English: Anagrelide is a medicine which interferes with the development of platelets.
Slovenian: Anagrelid je zdravilo, ki ovira razvoj krvnih ploščic.
English: A capsule size 4 (approximately 14.3 x 5.3 mm) with a grey body and cap.
Slovenian: Kapsula velikosti št. 4 (približno 14,3 x 5,3 mm) s sivim telesom in pokrovčkom.
English: Effects of other active substances on anagrelide
Slovenian: Učinki drugih učinkovin na anagrelid
English: INFORMATION IN BRAILLE Carton only: anagrelide mylan 0.5 mg
Slovenian: PODATKI V BRAILLOVI PISAVI Samo na škatli: anagrelid mylan 0,5 mg
English: • Medicines that can alter your heart rhythm e.g. sotalol, amiodarone;
Slovenian: • zdravila, ki lahko vplivajo na srčni ritem, npr. sotalol, amiodaron;
English: The contents of the capsules should not be crushed or diluted in a liquid.
Slovenian: Ne sme jih zdrobiti ali raztopiti njihove vsebine v tekočini.
English: High-density polyethylene (HDPE) bottle of 30 ml or 75 ml with a tamper evident, child-resistant polypropylene (PP) closure with a desiccant.
Slovenian: Plastenka iz polietilena visoke gostote (HDPE) s prostornino 30 ml ali 75 ml s polipropilensko (PP) za otroke varno zaporko, ki omogoča evidentiranje odprtja in s sušilnim sredstvom.
English: • If you were born with or have family history of prolonged QT interval (seen on ECG, electrical recording of the heart), or you are taking other medicines that result in abnormal ECG changes or if you have low levels of electrolytes e.g. potassium, magnesium or calcium (see section
Slovenian: • če ste se rodili s podaljšanim intervalom QT oziroma imate podaljšan interval QT v družinski anamnezi (vidno na EKG posnetku, električnem posnetku srca) ali pa jemljete druga zdravila,
English: In male rats, there was no effect on fertility or reproductive performance with anagrelide.
Slovenian: Pri samcih podgan niso opazili učinkov anagrelida na plodnost ali sposobnost razmnoževanja.
English: Depression Amnesia Confusion Insomnia Paraesthesia Hypoaesthesia Nervousness Dry mouth
Slovenian: Bolezni živčevja glavobol omotica depresija izguba spomina zmedenost nespečnost parestezija hipestezija nervoza suha usta migrenski glavobol disartrija dremavica nenormalna koordinacija
English: In a pre- and post-natal development study in female rats, anagrelide at oral doses of ≥ 10 mg/kg produced a non-adverse increase in gestational duration.
Slovenian: Anagrelid je v študiji prenatalnega in postnatalnega razvoja pri samicah podgan pri peroralnih odmerkih ≥10 mg/kg povzročil neškodljivo podaljšanje trajanja brejosti.
English: Therefore, the potential risks of the concomitant use of anagrelide with acetylsalicylic acid should be assessed, particularly in patients with a high risk profile for haemorrhage before treatment is initiated.
Slovenian: Zato je treba pred začetkom zdravljenja ugotoviti morebitna tveganja ob hkratni uporabi anagrelida z acetilsalicilno kislino, še posebej pri bolnikih z velikim tveganjem za krvavitve.
English: • Medicines used to treat heart disorders, for example, milrinone, enoximone, amrinone,
Slovenian: • zdravila, ki se uporabljajo za zdravljenje motenj srca, npr. milrinon, enoksimon, amrinon, olprinon in cilostazol;
English: Following repeated oral administration of anagrelide in dogs, subendocardial haemorrhage and focal myocardial necrosis was observed at 1 mg/kg/day or higher in males and females with males being more sensitive.
Slovenian: Pri ponavljajočem peroralnem dajanju anagrelida so pri psih opazili pri odmerku 1 mg/kg/dan ali več subendokardialne krvavitve in fokalno miokardialno nekrozo tako pri samcih kot pri samicah, pri čemer so bili samci občutljivejši.
English: • If you have moderate or severe kidney problems.
Slovenian: • če imate zmerne ali hude težave z delovanjem ledvic.
English: • a history of thrombo-haemorrhagic events.
Slovenian: • trombohemoragični dogodki v anamnezi.
English: Show them the pack of Anagrelide Mylan.
Slovenian: Pokažite mu ovojnino zdravila Anagrelid Mylan.
English: Other medicines and Anagrelide Mylan
Slovenian: Druga zdravila in zdravilo Anagrelide Mylan
English: Nausea Flatulence
Slovenian: Okvara ledvic
English: Effects of anagrelide on other active substances
Slovenian: Učinki anagrelida na druge učinkovine
English: Talk to your doctor before taking Anagrelide Mylan:
Slovenian: Pred začetkom jemanja zdravila Anagrelid Mylan se posvetujte z zdravnikom:
English: The European Medicines Agency will review any new information on the reference medicine every year and any updates for the reference medicine will also be included as appropriate in the information for Anagrelide Mylan, such as this leaflet.
Slovenian: Evropska agencija za zdravila bo vsako leto ponovno pregledala vse nove podatke o tem zdravilu.
English: In a paediatric registry study, median platelet counts were reduced from diagnosis and maintained for up to 18 months in 14 paediatric ET patients (4 children, 10 adolescents) with anagrelide treatment.
Slovenian: V pediatrični študiji za pripravo registra se je pri 14 pediatričnih bolnikih z ET (4 otroci, 10 mladostnikov), ki so se zdravili z anagrelidom, mediana koncentracija trombocitov od postavitve diagnoze zmanjšala in ostala takšna do 18 mesecev dolgo.
English: Patients should be evaluated for signs and symptoms of underlying cardiopulmonary disease prior to initiating and during anagrelide therapy.
Slovenian: Bolnike je treba pred začetkom zdravljenja in med zdravljenjem z anagrelidom oceniti glede znakov in simptomov osnovne kardiopulmonalne bolezni.
English: A pre-treatment cardiovascular examination, including a baseline ECG and echocardiography is recommended for all patients prior to initiating therapy with anagrelide.
Slovenian: Pred uvedbo zdravljenja z anagrelidom je za vse bolnike priporočljiv kardiovaskularni pregled, ki vključuje izhodiščni EKG posnetek in ehokardiografijo.
English: Typically cytoreductive therapy is considered in high risk paediatric patients.
Slovenian: Pri pediatričnih bolnikih z velikim tveganjem pride običajno v poštev citoreduktivno zdravljenje.
English: Platelet targets are assigned on an individual patient basis by the treating physician.
Slovenian: Ciljne vrednosti trombocitov določi lečeči zdravnik za vsakega bolnika posebej.
English: Diplopia Vision abnormal
Slovenian: Očesne bolezni diplopija nenormalen vid
English: MARKETING AUTHORISATION NUMBER EU/1/17/1256/001
Slovenian: ŠTEVILKA DOVOLJENJA ZA PROMET EU/1/17/1256/001
English: In female rats increases in pre- and post-implantation losses and a decrease in the mean number of live embryos was observed at 30 mg/kg/day.
Slovenian: Pri podganjih samicah so pri odmerku 30 mg/kg/dan opazili zvečanje predugnezditvenih in po-ugnezditvenih izgub in zmanjšanje povprečnega števila živih zarodkov.
English: Tabulated list of adverse reactions
Slovenian: Pregleden seznam neželenih učinkov
English: Frequency of adverse reactions
Slovenian: Pogostnost neželenih učinkov zdravila
English: Anagrelide Mylan should not be taken while breast-feeding.
Slovenian: Zdravila Anagrelid Mylan v času dojenja ne smete jemati.
English: Cases of pulmonary hypertension have been reported in patients treated with anagrelide.
Slovenian: Pri bolnikih, zdravljenih z anagrelidom, so poročali o primerih pljučne hipertenzije.
English: The potential risks and benefits of anagrelide therapy in a patient with impairment of renal function should be assessed before treatment is commenced (see section 4.3).
Slovenian: Morebitna tveganja in koristi pri zdravljenju z anagrelidom pri bolnikih s poslabšanim delovanjem ledvic je treba oceniti pred začetkom zdravljenja (glejte poglavje 4.3).
English: MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALEC (IZDELOVALCI), ODGOVOREN (ODGOVORNI) ZA SPROŠČANJE SERIJ
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Anagrelide Mylan 0.5 mg hard capsules
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Anagrelid Mylan 0,5 mg trde kapsule
English: MedDRA System Organ Class
Slovenian: MedDRA podatkovna baza glede na organske sisteme
English: METHOD AND ROUTE OF ADMINISTRATION Oral use.
Slovenian: POSTOPEK IN POT UPORABE ZDRAVILA peroralna uporaba
English: Do not take Anagrelide Mylan
Slovenian: Ne jemljite zdravila Anagrelid Mylan
English: Patients are advised not to drive or operate machinery while taking anagrelide if dizziness is experienced.
Slovenian: V primeru omotice ob jemanju anagrelida naj bolniki ne vozijo ali upravljajo strojev.
English: Anagrelide Mylan is available in plastic bottles of 30 ml or 75 ml with a tamper evident, child-resistant closure and a desiccant.
Slovenian: Zdravilo Anagrelid Mylan je na voljo v 30-mililitrskih ali 75-mililitrskih plastenkah z za otroke varno zaporko, ki omogoča evidentiranje odpiranja in ima sušilno sredstvo, vsebujejo pa 100 trdih kapsul.
English: Breast-feeding should be discontinued during treatment with anagrelide.
Slovenian: Med zdravljenjem z anagrelidom je treba prenehati z dojenjem.
English: Titanium dioxide (E171)
Slovenian: Anagrelid Mylan 1 mg trde kapsule želatina titanov dioksid (E171) črni železov oksid (E172)
English: Uncommon: Heart failure (signs include shortness of breath, chest pain, swelling of the legs due to fluid build-up), severe problem with the rate or rhythm of the heart beat (ventricular tachycardia, supraventricular tachycardia or atrial fibrillation), inflammation of the pancreas which causes severe abdominal and back pain (pancreatitis), vomiting blood or passing bloody or black stools, severe reduction in blood cells which can cause weakness, bruising, bleeding or infections (pancytopenia), increased pressure in the lung arteries (signs include shortness of breath, swelling in legs or ankles and lips and skin can turn bluish colour).
Slovenian: Občasni: popuščanje srca (znaki vključujejo kratko sapo, bolečine v prsih, otekanje spodnjih udov zaradi kopičenja tekočine), velike težave s frekvenco ali ritmom srčnega utripa (ventrikularna tahikardija, supraventrikularna tahikardija ali atrijska fibrilacija), vnetje trebušne slinavke, ki povzroči: močno bolečino v trebuhu in križu (pankreatitis), bruhanje krvi ali iztrebljanje krvavega ali črnega blata, močno zmanjšanje števila krvničk, ki lahko povzroči oslabelost, podplutbe, krvavitve ali okužbe (pancitopenija), povečan tlak v pljučnih arterijah (znaki vključujejo kratko sapo ter morebitno pomodrelost ustnic in kože).
English: Gastrointestinal haemorrhage Pancreatitis Anorexia Dyspepsia Constipation Gastrointestinal disorder
Slovenian: Bolezni prebavil driska bruhanje bolečine v trebuhu navzea vetrovi gastrointestinalna krvavitev vnetje trebušne slinavke anoreksija prebavne motnje zaprtje gastrointestinalne motnje kolitis gastritis krvavitev dlesni
English: Rare side effects: may affect up to 1 in 1,000 people Bleeding gums, weight gain, severe chest pain (angina pectoris), heart muscle disease, (signs include fatigue, chest pain and palpitations), enlarged heart, accumulation of fluid around the heart, loss of coordination, difficulty in speaking, dry skin, migraine, visual disturbances or double vision, ringing in the ears, dizziness on standing up (especially when getting up from a sitting or lying position), increased need to pass water at night, pain, ‘flu-like' symptoms, sleepiness, widening of blood vessels, inflammation of the large bowel (signs include: diarrhoea, usually with blood and mucus, stomach pain, fever), inflammation of the stomach (signs include: pain, nausea, vomiting), area of abnormal density in the lung, increased creatinine level in blood tests, which may be a sign of kidney problems.
Slovenian: Redki neželeni učinki: pojavijo se lahko pri največ 1 od 1.000 bolnikov krvavenje dlesni, pridobitev telesne mase, močna bolečina v prsih (angina pektoris), obolenje srčne mišice (znaki vključujejo utrujenost, bolečino v prsih in palpitacije), zvečanje srca, kopičenje tekočine okrog srca, izguba koordinacije, težave z govorom, suha koža, migrenski glavobol, poslabšanje vida ali dvojni vid, zvonjenje v ušesih, omedlevica v pokončnem položaju (posebno pri vstajanju iz sedečega ali ležečega položaja), povečana potreba po odvajanju vode ponoči, bolečine, gripi podobni simptomi, zaspanost, razširitev krvnih žil, vnetje debelega črevesa (znaki vključujejo: drisko, navadno s krvjo in sluzjo, bolečine v trebuhu, povišano telesno temperaturo), vnetje želodca (znaki vključujejo: bolečino, slabost, bruhanje), predel nenormalne gostote v pljučih, zvečana koncentracija kreatinina pri krvnih preiskavah, ki je lahko znak težav z ledvicami.
English: Anagrelide at ≥ 60 mg/kg increased parturition time and mortality in the dam and foetus respectively.
Slovenian: Anagrelid je v odmerkih ≥60 mg/kg podaljšal kotitev pri podganji samici in zvečal smrtnost pri plodu.
English: 6.4 Special precautions for storage
Slovenian: 4.4 Posebna opozorila in previdnostni ukrepi
English: Women of child-bearing potential should use adequate birth-control measures during treatment with anagrelide.
Slovenian: Ženske v rodni dobi morajo uporabljati učinkovito kontracepcijsko metodo med zdravljenjem z anagrelidom.
English: NAME OF THE MEDICINAL PRODUCT Anagrelide Mylan 0.5 mg hard capsules Anagrelide Mylan 1 mg hard capsules
Slovenian: IME ZDRAVILA Anagrelid Mylan 0,5 mg trde kapsule Anagrelid Mylan 1 mg trde kapsule
English: Anagrelide Mylan contains lactose.
Slovenian: Zdravilo Anagrelid Mylan vsebuje laktozo.
English: How to store Anagrelide Mylan
Slovenian: Kako jemati zdravilo Anagrelid Mylan
English: Anagrelide Mylan 0.5 mg hard capsules
Slovenian: Anagrelid Mylan 0,5 mg trde kapsule
English: Anagrelide Mylan contains lactose
Slovenian: Zdravilo Anagrelid Mylan vsebuje laktozo
English: What Anagrelide Mylan looks like and contents of the pack Anagrelide Mylan 0.5 mg hard capsules have a white body and cap.
Slovenian: Anagrelid Mylan 0,5 mg trde kapsule imajo belo telo in pokrovček.
English: Common side effects: may affect up to 1 in 10 people Dizziness, tiredness, rapid heart beat, irregular or strong heartbeat (palpitations), feeling sick (nausea), diarrhoea, stomach pain, wind, being sick (vomiting), reduction in red blood cell count (anaemia), fluid retention or rash.
Slovenian: Pogosti neželeni učinki: pojavijo se lahko pri največ 1 od 10 bolnikov vrtoglavica, utrujenost, pospešen srčni utrip, nereden ali močan srčni utrip (palpitacije), slabost, driska, bolečine v trebuhu, vetrovi, bruhanje, zmanjšanje števila rdečih krvničk (anemija), zastajanje tekočine ali izpuščaji.
English: You must stop breast-feeding if you are taking Anagrelide Mylan.
Slovenian: Če jemljete zdravilo Anagrelid Mylan, morate prenehati z dojenjem.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/17/1256/001
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/17/1256/001
English: The no observed effect level (NOEL) for male dogs (0.3 mg/kg/day) corresponds to 0.1, 0.1, and 1.6-fold the AUC in humans for anagrelide at 2 mg/day, and the metabolites BCH24426 and RL603, respectively.
Slovenian: Pri odmerku, pri katerem ni več mogoče opaziti učinka (no observed effect level (NOEL)) pri pasjih samcih (0,3 mg/kg/dan), je vrednost AUC za anagrelid 0,1-kratnik, vrednost AUC za presnovek BCH24426 0,1-kratnik in vrednost AUC presnovek RL603 1,6-kratnik vrednosti AUC pri ljudeh, ki so prejemali odmerek 2 mg/dan.
English: What Anagrelide Mylan looks like and contents of the pack Anagrelide Mylan 1 mg hard capsules have a grey body and cap.
Slovenian: Anagrelid Mylan 1 mg trde kapsule imajo sivo telo in pokrovček.
English: Anagrelide Mylan 1 mg hard capsules
Slovenian: Anagrelid Mylan 1 mg trde kapsule
English: MARKETING AUTHORISATION NUMBER(S) EU/1/17/1256/002
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/17/1256/002
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING
Slovenian: PODATKI NA ZUNANJI OVOJNINI IN PRIMARNI OVOJNINI ŠKATLA IN NALEPKA NA PLASTENKI
English: sleeplessness, depression, confusion, nervousness, dry mouth, loss of memory, breathlessness, nosebleed, serious lung infection with fever, shortness of breath, cough, phlegm; hair loss, skin itching or discolouration, impotence, chest pain, reduction in blood platelets, which increases the risk of bleeding or bruising (thrombocytopenia), accumulation of fluid around the lungs or an increase in liver enzymes.
Slovenian: zasoplost, krvavenje iz nosa, resna okužba pljuč s povišano telesno temperaturo, kratko sapo, kašljem, gnojnim izkašljevanjem, izpadanje las, srbenje ali razbarvanje kože, impotenca (nezmožnost doseganja in vzdrževanja erekcije), bolečina v prsih, zmanjšanje koncentracije krvnih ploščic, ki zveča tveganje krvavitev ali podplutb (trombocitopenija), kopičenje tekočine okrog pljuč ali zvišanje jetrnih encimov.
English: The potential risks and benefits of anagrelide therapy in a patient with impairment of renal function should be assessed before treatment is commenced (see sections 4.2 and 4.3).
Slovenian: Pred začetkom zdravljenja je treba ugotoviti morebitna tveganja in koristi ob zdravljenju z anagrelidom pri bolnikih s poslabšanim delovanjem ledvic (glejte poglavji 4.2 in 4.3).
English: Anagrelide 1 mg hard capsules
Slovenian: Anagrelid 1 mg trde kapsule
English: Pruritus
Slovenian: Trombociti
English: Anagrelide Mylan 0.5 mg hard capsules anagrelide
Slovenian: Anagrelid Mylan 0,5 mg trde kapsule anagrelid
English: Blood and lymphatic system disorders
Slovenian: Bolezni krvi in limfatičnega sistema anemija pancitopenija trombocitopenija krvavitev ekhimoza
English: At the NOEL dose (30 mg/kg/day), the AUCs for anagrelide and the metabolites BCH24426 and RL603 were 425-, 31- and 13-fold higher than the AUC in humans administered an oral dose of anagrelide 2 mg/day, respectively.
Slovenian: Pri odmerku, pri katerem ni več mogoče opaziti učinka (30 mg/kg/dan) so bile vrednosti za anagrelid 425- krat večje, vrednosti AUC za presnovek BCH24426 31-krat večje in vrednosti AUC za presnovek RL603 13- krat večje kot pri ljudeh, ki so prejemali odmerek 2 mg/dan.
English: Interstitial lung disease including pneumonitis and allergic alveolitis
Slovenian: Ušesne bolezni, vključno z motnjami labirinta tinitus
English: PHARMACEUTICAL PARTICULARS 6.1 List of excipients Capsule contents
Slovenian: 6.1 Seznam pomožnih snovi
English: Uncommon side effects: may affect up to 1 in 100 people A feeling of weakness or feeling unwell, high blood pressure, irregular heart beat, fainting, chills or fever, indigestion, loss of appetite, constipation, bruising, bleeding, swelling (oedema), weight loss, muscle aches, painful joints, back pain, decreased or loss of feeling or sensation such as numbness, especially in the skin, abnormal feeling or sensation such as tingling and ‘pins and needles',
Slovenian: Občasni neželeni učinki: pojavijo se lahko pri največ 1 od 100 bolnikov občutek šibkosti ali slabo počutje, visok krvni tlak, nereden srčni utrip, omedlevica, mrzlica ali povišana telesna temperatura, prebavne težave, izguba teka, zaprtje, modrice, krvavitve, otekanje (edem), izguba telesne mase, bolečine v mišicah, bolečine v sklepih, bolečine v križu, zmanjšanje ali izguba občutka ali zaznavanja, npr. odrevenelost, posebno v koži, nenormalen občutek ali zaznavanje, npr. zbadanje in mravljinčenje, nespečnost, depresija, zmedenost, nervoza, suha usta, izguba spomina,
English: Pulmonary hypertension Pneumonia Pleural effusion Dyspnoea Epistaxis
Slovenian: Bolezni jeter, žolčnika in žolčevodov zvišana koncentracija jetrnih encimov hepatitis
English: The effects of medicinal products with similar properties such as the inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.
Slovenian: • Anagrelid je zaviralec PDE III. Anagrelid lahko poslabša učinke zdravil s podobnimi lastnostmi, kot so inotropna zdravila milrinon, enoksimon, amrinon, olprinon in cilostazol.
English: What Anagrelide Mylan contains
Slovenian: Kaj vsebuje zdravilo Anagrelid Mylan
English: At the NOEL dose (3 mg/kg/day), the AUCs for anagrelide and the metabolites BCH24426 and RL603 were 14, 2 and 2-fold higher than the AUC in humans administered an oral dose of anagrelide 2 mg/day.
Slovenian: Pri odmerku, pri katerem ni več mogoče opaziti učinka (3 mg/kg/dan) so bile vrednosti AUC za anagrelid 14- krat večje, vrednosti AUC za presnovek BCH24426 2- krat večje in vrednosti AUC presnovek RL603 2- krat večje kot pri ljudeh, ki so prejemali odmerek 2 mg/dan.
English: NAME OF THE MEDICINAL PRODUCT Anagrelide Mylan 0.5 mg hard capsules anagrelide
Slovenian: IME ZDRAVILA Anagrelid Mylan 0,5 mg trde kapsule anagrelid