FrancophonIA/ELRC3.0 huggingface dataset:
English: If indicated, elimination of unabsorbed nelfinavir should be achieved by emesis or gastric lavage.
Slovenian: Če je indicirano, lahko izločanje neabsorbiranega nelfinavirja dosežemo z bruhanjem ali izpiranjem želodca.
English: The prescriber should assure that the caregiver understands the importance of monitoring adherence and the appropriate method to prepare and administer Viracept tablets to children in each weight band.
Slovenian: Predpisovalec zdravila mora zagotoviti, da oseba, ki skrbi za bolnika, razume pomembnost spremljanja skladnosti jemanja zdravila z navodili ter pravilnega načina priprave in dajanja VIRACEPT tablet otrokom v vsakem območju telesne mase.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER ‘Logo'
Slovenian: IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM ‘Logo'
English: Food increases nelfinavir exposure and decreases nelfinavir pharmacokinetic variability relative to the fasted state.
Slovenian: Hrana poveča izpostavljenost nelfinavirju in zmanjša farmakokinetične razlike nelfinavirja v primerjavi z uživanjem zdravila na tešče.
English: Absorption: after single or multiple oral doses of 500 to 750 mg (two to three 250 mg tablets) with food, peak nelfinavir plasma concentrations were typically achieved in 2 to 4 hours.
Slovenian: Absorpcija: po enkratnih ali večkratnih peroralnih odmerkih 500 do 750 mg (dve do tri 250 mg tablete), zaužitih s hrano, so bile največje koncentracije nelfinavirja v plazmi dosežene v 2 do 4 urah.
English: Tél/Tel: +32 (0) 2 525 82 11
Slovenian: Tél/Tel: +32 (0) 2 525 82 11 България
English: A. MANUFACTURING AUTHORISATION HOLDER(S) RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IMETNIKI DOVOLJENJA ZA IZDELAVO ZDRAVILA, ODGOVORNI ZA SPROŠČANJE SERIJE
English: Rare (affect less than 1 in 1000 people):
Slovenian: Redki (pojavijo se pri manj kot 1 od 1000 ljudi):
English: The prescriber should advise the caregiver to carefully monitor increases in weight of the child to ensure that the appropriate total daily dose is taken.
Slovenian: Predpisovalec zdravila mora svetovati osebi, ki skrbi za bolnika, naj skrbno spremlja povečanje otrokove telesne mase, da zagotovi otroku ustrezen celokupni dnevni odmerek zdravila.
English: Tell your doctor or pharmacist if you are taking any of the following medicines:
Slovenian: Obvestite svojega zdravnika ali farmacevta, če jemljete katerokoli od navedenih zdravil:
English: When used with nelfinavir, the lowest possible dose of atorvastatin should be administered.
Slovenian: Pri sočasnem jemanju nelfinavirja in atorvastatina je treba dati najnižji možni odmerek atorvastatina.
English: WHAT VIRACEPT IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO VIRACEPT IN ZA KAJ GA UPORABLJAMO
English: • Herbal preparations containing St. John's Wort (for depression or improving your mood)
Slovenian: • pripravki rastlinskega izvora, ki vsebujejo šentjanževko (za depresijo in izboljšanje volje),
English: INFORMATION IN BRAILLE viracept 250 mg
Slovenian: PODATKI V BRAILLOVI PISAVI viracept 250 mg
English: The absolute bioavailability of VIRACEPT has not been determined.
Slovenian: Absolutne biološke uporabnosti zdravila VIRACEPT niso določili.
English: Rare (≥ 0.01 % - ≤ 0.1 %): hepatitis, hepatic enzymes increased and jaundice when nelfinavir is used in combination with other antiretroviral agents.
Slovenian: Redki (≥ 0,01 % - ≤ 0,1 %): hepatitis, povečane vrednosti jetrnih encimov in zlatenica pri uporabi nelfinavirja v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: There is no data available on nelfinavir excretion into human breast milk.
Slovenian: Podatkov o tem, ali se nelfinavir izloča tudi v materino mleko pri človeku, ni.
English: • Salmeterol (for asthma or chronic obstructive pulmonary disease (COPD)
Slovenian: • salmeterol (za zdravljenje astme ali kronične obstruktivne pljučne bolezni (KOPB),
English: VIRACEPT is indicated in antiretroviral combination treatment of human immunodeficiency virus (HIV-1) infected adults, adolescents and children of 3 years of age and older.
Slovenian: Zdravilo VIRACEPT je indicirano za kombinirano protiretrovirusno zdravljenje odraslih, mladostnikov in otrok, starih tri leta ali več, ki so okuženi z virusom humane imunske pomanjkljivosti (HIV-1).
English: A causal relationship has been evoked, although the mechanism of action has not been elucidated.
Slovenian: Čeprav mehanizem delovanja še ni pojasnjen, obstaja vzročna povezava.
English: Not applicable.
Slovenian: Ni bilo proučevano.
English: • Combination anti-retroviral therapy may cause changes in body shape due to changes in fat distribution.
Slovenian: • kombinirano protiretrovirusno zdravljenje lahko povzroči spremembe oblike telesa zaradi prerazporeditve maščevja.
English: Excipients: VIRACEPT oral powder contains aspartame (E951) as a sweetening agent.
Slovenian: Pomožne snovi: peroralni prašek VIRACEPT vsebuje sladilo aspartam (E951).
English: Vascular disorders: Rare (≥ 0.01 % - ≤ 0.1 %): increased spontaneous haemorrhage bleeding in patients with haemophilia.
Slovenian: Žilne bolezni: Redki (≥ 0,01 % - ≤ 0,1 %): povečana spontana krvavitev pri bolnikih s hemofilijo.
English: There is no specific antidote for overdose with nelfinavir.
Slovenian: Za preveliko odmerjanje nelfinavirja ni specifičnega antidota.
English: If you notice any of these symptoms please inform your doctor immediately.
Slovenian: Če opazite kateregakoli od teh simptomov, prosimo, da o tem takoj obvestite svojega zdravnika.
English: Co- administration with rifampicin is contra-indicated due to a reduction in exposure to nelfinavir.
Slovenian: Sočasno jemanje rifampicina je kontraindicirano zaradi zmanjšane izpostavljenosti nelfinavirju.
English: Lipodystrophy: Combination antiretroviral therapy has been associated with the redistribution of body fat (acquired lipodystrophy) in HIV patients.
Slovenian: Lipodistrofija: kombinirano protiretrovirusno zdravljenje je pri nekaterih bolnikih s HIV povezano s prerazporeditvijo telesne maščobe (pridobljena lipodistrofija).
English: Concomitant use of trazodone and nelfinavir may increase plasma concentrations of trazodone and a lower dose of trazodone should be considered.
Slovenian: Sočasna uporaba trazodona in nelfinavirja lahko poveča plazemske koncentracije trazodona in zato je treba razmisliti o nižjem odmerku trazodona.
English: Diarrhoea was the most commonly reported adverse event in children.
Slovenian: Pri otrocih je bil najpogosteje poročani neželeni dogodek driska.
English: Patients older than 13 years: the recommended dose of VIRACEPT 250 mg film-coated tablets is 1250 mg (five tablets) twice a day (BID) or 750 mg (three tablets) three times a day (TID) by mouth.
Slovenian: Bolniki, starejši od 13 let: priporočeni odmerek zdravila VIRACEPT 250 mg filmsko obložene tablete je 1250 mg (pet tablet) dvakrat na dan ali 750 mg (tri tablete) trikrat na dan peroralno.
English: Coadministration of nelfinavir with simvastatin or lovastatin may result in significant increases in simvastatin and lovastatin plasma concentrations and is contraindicated (see section 4.3).
Slovenian: Sočasno jemanje nelfinavirja s simvastatinom ali lovastatinom lahko privede do značilnega povečanja plazemskih koncentracij simvastatina in lovastatina in je kontraindicirano (glejte poglavje 4.3).
English: • Do not mix the powder with orange juice, apple sauce or other acidic liquids or foods.
Slovenian: • Praška ne smete mešati s pomarančnim sokom, jabolčnim sokom ali drugimi tekočinami ali hrano kislega okusa.
English: • High blood sugar (diabetes) or diabetes get worse.
Slovenian: • visok krvni sladkor (sladkorna bolezen) ali poslabšanje obstoječe sladkorne bolezni,
English: • This medicine is essentially ‘potassium-free' as it contains less than 1 mmol (39 milligrams) of potassium per dose.
Slovenian: • Zdravilo vsebuje manj kot 1 mmol (39 miligramov) kalija na odmerek, kar v bistvu pomeni
English: Also contains E95, sucrose palmitate, potassium.
Slovenian: Vsebuje tudi E951, saharozo palmitat, kalij.
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Slovenian: Bolniki s predhodno jetrno disfunkcijo, vključno s kroničnim aktivnim hepatitisom, imajo pri kombiniranem protiretrovirusnem zdravljenju povečano pogostnost nepravilnosti jetrne funkcije.
English: Each bottle contains 144 grams of powder and is supplied with a 1 gram scoop (white) and a 5 gram scoop (blue).
Slovenian: Vsaka steklenica vsebuje 144 gramov praška, v njej pa sta priloženi (bela) merica po 1 gram in (modra) merica po 5 gramov.
English: VIRACEPT oral powder contains potassium.
Slovenian: Peroralni prašek VIRACEPT vsebuje kalij.
English: Plasma levels of nelfinavir, which is metabolised predominantly by CYP2C19 and only partially by CYP3A4, are not greatly increased by co-administration with ritonavir, and therefore nelfinavir does not require co-administration with low-dose ritonavir .
Slovenian: Koncentracije nelfinavirja v plazmi, ki se pretežno presnavlja s CYP2C19 in le delno s CYP3A4, niso močno povišane ob sočasnem jemanju z ritonavirjem in zato sočasno jemanje nelfinavirja z majhnimi odmerki ritonavirja ni potrebno.
English: Based on in vitro data, nelfinavir is unlikely to inhibit other cytochrome P450 isoforms at concentrations in the therapeutic range.
Slovenian: Glede na podatke in vitro nelfinavir v terapevtskih koncentracijah najverjetneje ne zavira drugih izoencimskih oblik citokroma P450.
English: It is expected that in CYP2C19 poor metabolisers or in patients receiving concomitantly strong CYP2C19 inhibitors (see section 4.5), nelfinavir plasma levels would be elevated whereas levels of tert-butyl hydroxy nelfinavir would be negligible or non-measurable.
Slovenian: Pričakovati je, da bodo pri bolnikih s slabo aktivnostjo CYP2C19 ali pri bolnikih, ki sočasno prejemajo močne zaviralce CYP2C19 (glejte poglavje 4.5), plazemske koncentracije nelfinavirja zvišane, koncentracije terc-butil hidroksinelfinavirja pa zanemarljivo nizke ali celo nemerljive.
English: The bottle contains 144 g of oral powder.
Slovenian: Vsebnik vsebuje 144 g peroralnega praška.
English: • Immunosuppressant medicines such as tacrolimus or ciclosporin
Slovenian: • zaviralci imunske odzivnosti vključno s takrolimusom ali ciklosporinom,
English: • Table 3: if you give the medicine three times a day, you will give 25-35 mg nelfinavir each time for each kg of body weight, except for children who weigh from 10.5 to 12 kg, from 12 to 14 kg and from 18 to 22 kg.
Slovenian: • Preglednica 3: če dajete zdravilo trikrat na dan, potem boste vsakič dali 25-35 mg nelfinavirja za vsak kg telesne mase, razen otrokom ki tehtajo 10,5 do 12 kg, 12 do 14 kg in 18 do 22 kg.Ti otroci bodo prejeli različno število tablet ob vsakem obroku.
English: • Simvastatin or lovastatin (for lowering blood cholesterol)
Slovenian: • simvastatin ali lovastatin (za znižanje holesterola v krvi).
English: • Bone disease (osteonecrosis).
Slovenian: • Bolezni skeletnega sistema (osteonekroza).
English: Nelfinavir may lead to decreased AUC of phenytoin; therefore phenytoin concentrations should be monitored during concomitant use with nelfinavir.
Slovenian: Nelfinavir lahko povzroči zmanjšanje AUC fenitoina, zato je med sočasnim zdravljenjem z nelfinavirjem treba spremljati koncentracije fenitoina.
English: Co-administration of a PI with sildenafil is expected to substantially increase sildenafil concentration and may result in an increase in sildenafil associated adverse events, including hypotension, visual changes, and priapism.
Slovenian: Pri sočasni uporabi zaviralcev proteaz s sildenafilom se pričakuje znatno povečanje koncentracij sildenafila, kar lahko privede do povečanega pojava s sildenafilom povezanih neželenih dogodkov, vključno s hipotenzijo, spremembami vida in priapizmom.
English: VIRACEPT 50 mg/g oral powder is provided in HDPE plastic bottles fitted with polypropylene child resistant closures with a polyethylene liner.
Slovenian: Peroralni prašek VIRACEPT 50 mg/g je na voljo v plastičnih vsebnikih HDPE, opremljenih z za otroke varnimi polipropilenskimi zaporkami s polietilensko podlogo.
English: • Phenobarbital or carbamazepine (for fits or epilepsy)
Slovenian: • fenobarbital ali karbamazepin (za krče ali epilepsijo),
English: A pharmacokinetic study in HIV-positive patients compared multiple doses of 1250 mg twice daily (BID) with multiple doses of 750 mg three times daily (TID) for 28 days.
Slovenian: V farmakokinetični študiji pri HIV-pozitivnih bolnikih so primerjali večkratne odmerke 1250 mg dvakrat na dan z večkratnimi odmerki 750 mg trikrat na dan 28 dni.
English: The metabolism of pravastatinand fluvastatinis not dependent on CYP3A4, and interactions are not expected with nelfinavir.
Slovenian: Presnova pravastatina in fluvastatina ni odvisna od CYP3A4, zato ni pričakovati medsebojnega delovanja z nelfinavirjem.
English: Coadministration of midazolam with nelfinavir may cause a large increase in the concentration of this benzodiazepine.
Slovenian: Sočasno dajanje midazolama z nelfinavirjem lahko v veliki meri poviša koncentracijo tega benzodiazepina.
English: It is supplied in plastic bottles with plastic child resistant lids.
Slovenian: Na voljo je v plastičnih stekleničkah s plastično za otroke varno zaporko.
English: Dose adjustment for midazolam should be considered if more than a single dose is administered (Table 1)
Slovenian: Razmisliti je treba o prilagoditvi odmerka midazolama, zlasti, če je bil dan več kot en odmerek midazolama (Preglednica 1).
English: A greater than dose-proportional increase in nelfinavir plasma concentrations was observed after single doses; however, this was not observed after multiple dosing.
Slovenian: Po enkratnih odmerkih so ugotovili več kot od odmerka sorazmeren porast plazemskih koncentracij nelfinavirja, po večkratnem odmerjanju tega niso opazili.
English: Combination anti-retroviral therapy may cause changes in body shape due to changes in fat distribution.
Slovenian: Kombinirano protiretrovirusno zdravljenje lahko povzroči spremembe oblike telesa zaradi prerazporeditve maščevja.
English: For children aged 3 to 13 years, the recommended dose of Viracept tablets is based on their body weight.
Slovenian: Za otroke, stare od 3 do 13 let je priporočeni odmerek zdravila Viracept tablete odvisen od njihove telesne mase.
English: White to off-white amorphous powder.
Slovenian: Bel do skoraj bel amorfen prašek.
English: INFORMATION IN BRAILLE viracept 50 mg
Slovenian: PODATKI V BRAILLOVI PISAVI viracept 50 mg
English: Total grams of Powder per dose
Slovenian: 1 gram skupno gramov praška na odmerek
English: For children aged 3 to 13 years, the recommended dose of Viracept powder is based on their body weight.
Slovenian: Za otroke, stare od 3 do 13 let je priporočeni odmerek zdravila Viracept prašek odvisen od njihove telesne mase.
English: The side effects only rarely resulted into having to stop taking Viracept.
Slovenian: Zaradi neželenih učinkov je bilo redko treba prenehati z jemanjem zdravila Viracept.
English: The adverse reaction profile seen during paediatric clinical trials was similar to that for adults.
Slovenian: Profil neželenih učinkov, ki so ga opazili v pediatričnih študijah, je bil podoben profilu neželenih učinkov pri odraslih.
English: The oral powder contains: - microcrystalline cellulose - maltodextrin - dibasic potassium phosphate - crospovidone - hydroxypropyl methylcellulose - aspartame (E951) - sucrose palmitate - natural and artificial flavour
Slovenian: Peroralni prašek vsebuje: - mikrokristalno celulozo, - maltodekstrin, - kalijev hidrogenfosfat, - krospovidon, - hipromelozo, - aspartam (E951), - saharozo palmitat - naravno ter umetno aromo.
English: After multiple dosing with 750 mg every 8 hours for 28 days (steady-state), peak plasma concentrations (Cmax) averaged 3-4 µg/ml and plasma concentrations prior to the next dose (trough) were 1-3 µg/ml.
Slovenian: Po večkratnem odmerjanju s 750 mg vsakih 8 ur 28 dni (stanje dinamičnega ravnovesja), so znašale največje koncentracije v plazmi (Cmax) v povprečju 3 do 4 μg/ml, pred naslednjim odmerkom pa 1 do 3 μg/ml.
English: Treatment paradigms for several protease inhibitors, which are subject to this interaction, require the co-administration of low-dose ritonavir (‘boosting') in order to enhance plasma levels and optimise antiviral efficacy.
Slovenian: V primerih zdravljenja s posameznimi zaviralci proteaz, ki so podvrženi temu medsebojnemu delovanju, je treba sočasno dajati majhne odmerke ritonavirja (podporna terapija), da se povečajo koncentracije v plazmi in se doseže najugodnejši protivirusni učinek.
English: No dose adjustment for nelfinavir is recommended.
Slovenian: Prilagajanje odmerkov nelfinavirja ni priporočljivo.
English: The most commonly reported side effect in children is diarrhoea.
Slovenian: Neželeni učinek, o katerem so pri otrocih najpogosteje poročali, je driska.
English: N: number of subjects with evaluable pharmacokinetic results Ctrough values are not presented in the table because they are not available from all studies
Slovenian: 1Odmerek določen s protokolom (dejanski razpon odmerkov) N: število oseb s farmakokinetičnimi rezultati, ki jih je mogoče oceniti Vrednosti Cpred naslednjim odmerkom v preglednici niso predstavljene, ker niso na voljo za vse študije
English: • Rinse the glass with a half cup of water and swallow the rinse to ensure all of the dose is taken.
Slovenian: • kozarec poplaknite s pol kozarca vode in jo popijte, saj s tem zagotovite, da ste vzeli celoten
English: This helps your body to get the full benefit from your medicine.
Slovenian: Tako dobi vaše telo največ koristi od zdravila.
English: 95 % CI
Slovenian: 95 % interval zaupanja
English: The majority (87 %) of an oral 750 mg dose containing 14C-nelfinavir was recovered in the faeces; total faecal radioactivity consisted of nelfinavir (22 %) and numerous oxidative metabolites (78 %).
Slovenian: Večina (87 %) peroralnega 750 mg odmerka, ki vsebuje nelfinavir 14C, se je izločila z blatom; celotna radioaktivnost v blatu sestoji iz 22 % nelfinavirja in
English: There are two scoops provided in the box, a white 1 gram scoop and a blue 5 gram scoop.
Slovenian: V škatli sta priloženi dve merici, bela po 1 gram in modra po 5 gramov.
English: Each tablet contains 250 mg of nelfinavir.
Slovenian: Ena tableta vsebuje 250 mg nelfinavirja.
English: You will either give the medicine to your child two or three times a day with a
Slovenian: Otroku boste zdravilo dali bodisi dvakrat ali trikrat na dan z obrokom.
English: Herbal preparations containing St. John's wort (Hypericum perforatum) must not be used while taking nelfinavir due to the risk of decreased plasma concentrations and reduced clinical effects of nelfinavir (see section 4.5).
Slovenian: Pripravki rastlinskega izvora, ki vsebujejo šentjanževko (Hypericum perforatum), se med jemanjem nelfinavirja ne smejo uporabljati, ker se lahko zmanjšata koncentracija nelfinavirja v plazmi in njegov terapevtski učinek (glejte poglavje 4.5).
English: Midazolam is extensively metabolised by CYP3A4.
Slovenian: Midazolam se obsežno presnavlja preko CYP3A4.
English: Liver Disease: The safety and efficacy of nelfinavir has not been established in patients with significant underlying liver disorders.
Slovenian: Jetrno obolenje: varnost in učinkovitost nelfinavirja pri bolnikih, ki imajo hude motnje jetrnega delovanja, nista bili raziskani.
English: Uncommon - rare (≥ 0.01 % - ≤ 1 %): Combination antiretroviral therapy has been associated with redistribution of body fat (Lipodystrophy aquired) in HIV patients including the loss of peripheral and facial subcutaneous fat, increased intra-abdominal and visceral fat, breast hypertrophy and dorsocervical fat accumulation (lipohypertrophy buffalo hump).
Slovenian: Občasni-redki (≥ 0,01 % - ≤ 1 %): kombinirano protiretrovirusno zdravljenje je pri bolnikih s HIV povezano s prerazporeditvijo telesne maščobe (pridobljena lipodistrofija), vključno z izgubo periferne in obrazne podkožne maščobe, povečanjem maščobe na trebuhu in visceralnega maščevja, hipertrofijo prsi in dorzocervikalnim kopičenjem maščob (lipohipertrofija, bivolja grba).
English: The Viracept tablets must be taken by mouth.
Slovenian: Zdravilo Viracept tablete je treba jemati peroralno.
English: Combination antiretroviral therapy has been associated with metabolic abnormalities such asblood triglycerides increased, blood cholesterol increased, insulin resistance, hyperglycaemia and hyperlactaemia.
Slovenian: Kombinirano protiretrovirusno zdravljenje povezujejo tudi s presnovnimi motnjami, kot so povečana koncentracija trigliceridov v krvi, povečana koncentracija holesterola v krvi, odpornost na insulin, hiperglikemija in hiperlaktacidemija.
English: Therefore you must keep taking appropriate precautions to avoid giving the virus to others when you are taking Viracept.
Slovenian: Zato morate med jemanjem zdravila Viracept izvajati ustrezne varnostne ukrepe za preprečitev prenosa virusa na druge.
English: PDE-5 inhibitors for the treatment of pulmonary arterial hypertension (PAH) Tadalafil
Slovenian: Zaviralec PDE-5 za zdravljenje pljučne arterijske hipertenzije (PAH) tadalafil
English: At 48 weeks, approximately 75 % of the patients treated with nelfinavir 750 mg TID plus zidovudine and lamivudine remained below the level of detection of the assay (< 400 copies/ml); mean increase in CD4 cell counts was 198 cells/mm3 at 48 weeks in this group.
Slovenian: Po 48 tednih je približno 75 % bolnikov, zdravljenih s 750 mg nelfinavirja trikrat na dan v kombinaciji z zidovudinom in lamivudinom, ostalo pod mejo zaznave (< 400 kopij/ml); srednje število celic CD4 se je v tej skupini po 48 tednih povečalo za več kot 198 celic/mm3.
English: Since nelfinavir is highly protein bound, dialysis is unlikely to significantly remove it from blood.
Slovenian: Ker se nelfinavir močno veže na beljakovine, ga iz krvi z dializo ni mogoče odstraniti v večji količini.
English: Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Slovenian: Znaki osteonekroze so togost sklepa oz. sklepov, bolečine (zlasti v kolku, kolenu in rami) in težave z gibljivostjo.
English: MANUFACTURER'S BATCH NUMBER Batch
Slovenian: IZDELOVALČEVA ŠTEVILKA SERIJE IZDELAVE ZDRAVILA Serija
English: Metabolism: In vitro studies demonstrated that multiple cytochrome P-450 isoforms including CYP3A, CYP2C19/C9 and CYP2D6 are responsible for the metabolism of nelfinavir.
Slovenian: Presnova: nelfinavir se in vitro presnavlja z več izoencimi citokroma P 450, vključno s CYP3A, CYP2C19/C9 in CYP2D6.
English: Administration of VIRACEPT oral powder or tablets at a dose of approximately 25-30 mg/kg TID with food achieves steady-state plasma concentrations that are similar to those achieved in adult patients receiving 750 mg TID.
Slovenian: Po jemanju peroralnega praška ali tablet VIRACEPT v odmerkih po približno 25 do 30 mg/kg trikrat na dan s hrano, so bile plazemske koncentracije v stanju dinamičnega ravnovesja podobne koncentracijam doseženim pri odraslih bolnikih, ki so prejemali 750 mg zdravila trikrat na dan.
English: The further degradation of M8 appears to be catalysed by CYP3A4.
Slovenian: Nadaljnjo razgradnjo M8 najverjetneje katalizira CYP3A4.
English: Consider alternatives to fluticasone propionate, that are not metabolised by CYP3A4, such as beclometasone, particularly for long-term use.
Slovenian: Premislite o uporabi drugih možnih zdravil, kot je beklometazon, ki se ne presnavljajo s CYP3A4, posebej pri dolgotrajni uporabi.
English: Nelfinavir demonstrated additive to synergistic effects against HIV in combination with reverse transcriptase inhibitors zidovudine (ZDV), lamivudine (3TC), didanosine (ddI), zalcitabine (ddC) and stavudine (d4T) without enhanced cytotoxicity.
Slovenian: Nelfinavir je imel v kombinaciji z zaviralci reverzne transkriptaze, zidovudinom (ZDV), lamivudinom (3TC), didanozinom (ddI), zalcitabinom (ddC) in stavudinom (d4T), aditivne do sinergistične učinke proti virusu HIV brez povečane citotoksičnosti.