FrancophonIA/ELRC3.0 huggingface dataset:
English: In the first kidney disease study, Aprovel was more effective than placebo at reducing the risk of developing kidney damage as measured by protein excretion.
Croatian: U prvom ispitivanju bolesti bubrega Aprovel je bio djelotvorniji od placeba u smanjivanju rizika od nastanka oštećenja funkcije bubrega kako je izmjereno izlučivanjem proteina.
English: In the blood pressure studies, Aprovel was more effective than placebo at reducing diastolic blood pressure and had similar effects to the other medicines for hypertension.
Croatian: U ispitivanjima krvnoga tlaka, Aprovel je bio djelotvorniji od placeba u smanjivanju dijastoličkog krvnog tlaka i imao je slično djelovanje kao drugi antihipertenzivi.
English: How has Aprovel been studied?
Croatian: Kako je Aprovel ispitan?
English: Aprovel was originally studied in 11 trials for its effects on blood pressure.
Croatian: Djelovanje lijeka Aprovel na krvni tlak izvorno je ispitano u 11 istraživanja.
English: How does Aprovel work?
Croatian: Kako Aprovel djeluje?
English: What is Aprovel used for?
Croatian: Za što se Aprovel koristi?
English: How is Aprovel used?
Croatian: Kako se Aprovel koristi?
English: ‘Essential' means that the hypertension has no obvious cause.
Croatian: Aprovel se koristi za liječenje esencijalne hipertenzije (visokog krvnog tlaka) u odraslih osoba. „Esencijalna” znači da hipertenzija nema nekog očitog uzroka.
English: For the full list of all side effects reported with Aprovel, see the package leaflet.
Croatian: Potpuni popis nuspojava koje su zabilježene s lijekom Aprovel potražite u uputi o lijeku.
English: Always take Ipreziv exactly as your doctor has told you.
Croatian: Uvijek uzmite Ipreziv točno onako kako Vam je rekao liječnik.
English: It is important to keep taking Ipreziv every day.
Croatian: Važno je da neprekidno uzimate Ipreziv svaki dan.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 7 December 2011
Croatian: DATUM PRVOG ODOBRENJA /DATUM OBNOVE ODOBRENJA 7. prosinca 2011.
English: WHAT IPREZIV IS AND WHAT IT IS USED FOR
Croatian: ŠTO JE IPREZIV I ZA ŠTO SE KORISTI
English: Older people (65 years and over)
Croatian: Starije osobe (u dobi od 65 ili više godina)
English: You can take Ipreziv with or without food.
Croatian: Ipreziv možete uzimati sa hranom ili bez nje.
English: Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzimali bilo koje druge lijekove, uključujući i one koje ste nabavili bez recepta.
English: This leaflet was last approved in {MM/YYYY}.
Croatian: Uputa je zadnji puta odobrena u {MM/GGGG }.
English: If you take more Ipreziv than you should
Croatian: Ako uzmete više Ipreziva nego što ste trebali
English: OTHER SPECIAL WARNING(S), IF NECESSARY
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A) AKO JE POTREBNO
English: Therefore, Ipreziv should not be given to children or adolescents.
Croatian: Stoga se Ipreziv ne smije davati djeci ili adolescentima.
English: Your doctor will normally advise you to stop taking Ipreziv before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Ipreziv.
Croatian: Liječnik će Vam obično savjetovati da prestanete uzimati Ipreziv prije nego zatrudnite ili čim saznate da ste trudni i reći će Vam da uzmete drugi lijek umjesto Ipreziva.
English: Therefore do not stop taking Ipreziv without first talking to your doctor about alternative treatment options.
Croatian: Stoga nemojte prestati uzimati Ipreziv a da prethodno niste razgovarali s liječnikom o drugim mogućnostima liječenja.
English: If you stop taking Ipreziv, your blood pressure may increase again.
Croatian: Ako prestanete uzimati Ipreziv Ako prestanete uzimati Ipreziv, krvni tlak Vam se može ponovno povisiti.
English: Other medicines and Ipreziv
Croatian: Drugi lijekovi i Ipreziv
English: The frequency of this event is highest when amlodipine is taken alone.
Croatian: Učestalost ovog događaja najveća je kad se amlodipin uzima sam.
English: However, when taking any antihypertensive it should be taken into account that occasionally dizziness or tiredness may occur.
Croatian: Međutim, kad se uzimaju bilo koji antihipertenzivi, potrebno je uzeti u obzir da povremeno mogu nastati omaglica i umor.
English: Black population
Croatian: Crna populacija
English: Rebound hypertension was not observed following abrupt cessation of Ipreziv therapy after 6 months of treatment.
Croatian: Nije bila opažena povratna hipertenzija nakon naglog prekida terapije Iprezivom nakon 6 mjeseci liječenja.
English: The safety and efficacy of Ipreziv in children and adolescents 0 to < 18 years have not yet been established.
Croatian: Sigurnost i djelotvornost Ipreziva u djece i adolescenata u dobi od 0 do < 18 godina još nisu ustanovljene.
English: WHAT YOU NEED TO KNOW BEFORE YOU TAKE IPREZIV
Croatian: Što morate znati prije nego počnete uzimati Ipreziv
English: Ipreziv had a lower incidence of cough (1.2%) compared with ramipril (8.2%).
Croatian: Ipreziv je imao nižu incidenciju kašlja (1,2%) u usporedbi s ramiprilom (8,2%).
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to angiotensin converting enzyme inhibitors during the first trimester of pregnancy has not been conclusive; however, a small increase in risk cannot be excluded.
Croatian: Epidemiološki dokazi u pogledu rizika teratogenosti nakon izlaganja inhibitorima angiotenzin konvertirajućeg enzima tijekom prvog tromjesečja trudnoće nisu konačni; međutim, ne može se isključiti malo povećanje rizika.
English: M-I and M-II do not contribute to the pharmacologic activity of Ipreziv.
Croatian: M-I i M-II ne pridonose farmakološkom djelovanju Ipreziva.
English: Ipreziv can affect the way some other medicines work and some medicines can have an effect on Ipreziv.
Croatian: Ipreziv može utjecati na način na koji djeluju neki drugi lijekovi, kao što i neki lijekovi mogu imati učinak na Ipreziv.
English: - The usual starting dose is 40 mg once a day.
Croatian: - Uobičajena početna doza je 40 mg jedanput na dan.
English: Pack sizes: One blister pack contains either 14 tablets or 15 tablets.
Croatian: Veličine pakiranja: Jedno blister pakiranje sadrži 14 tableta ili 15 tableta.
English: If you forget to take Ipreziv Do not take a double dose to make up for a forgotten dose.
Croatian: Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljenu dozu.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Ipreziv in one or more subsets of the paediatric population in hypertension (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je odgodila obvezu podnošenja rezultata ispitivanja lijeka Ipreziv u jednoj ili više podskupina pedijatrijske populacije u hipertenziji (vidjeti dio 4.2 za informacije o primjeni u pedijatriji).
English: There is currently no experience on the use of Ipreziv in patients who have recently undergone kidney transplantation.
Croatian: Trenutno nema iskustva s primjenom Ipreziva u bolesnika kojima je nedavno presađen bubreg.
English: Pharmacotherapeutic group: Angiotensin II antagonists, plain ATC Code: C09CA09
Croatian: Farmakoterapijska skupina: antagonisti angiotenzina II, čisti ATK oznaka: C09CA09
English: Ipreziv blocks this effect so that the blood vessels relax, which helps lower your blood pressure.
Croatian: Ipreziv blokira taj učinak tako da se krvne žile opuštaju, što pridonosi sniženju krvnog tlaka.
English: Therefore, the use of Ipreziv is not recommended in these patients.
Croatian: Stoga se ne preporučuje primjena Ipreziva u tih bolesnika.
English: Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na web stranici Europske agencije za lijekove http://www.ema.europa.eu
English: STOP taking Ipreziv and seek medical help immediately if you have any of the following allergic reactions, which occur rarely (less than 1 in 1000 people): - Difficulties in breathing, or swallowing, or swelling of the face, lips, tongue and/or throat
Croatian: PRESTANITE uzimati Ipreziv i odmah potražite liječničku pomoć ako imate neku od sljedećih alergijskih reakcija, koje rijetko nastaju (u manje od 1 na 1000 osoba): - otežano disanje ili gutanje ili oticanje lica, usana, jezika i/ili grla (angioedem). - svrbež kože s uzdignutim kvržicama.
English: No overall differences in safety and effectiveness were observed between elderly patients and younger patients, but greater sensitivity to blood pressure lowering effects in some elderly individuals cannot be ruled out (see section 4.2).
Croatian: Nisu bile opažene ukupne razlike u sigurnosti i djelotvornosti Ipreziva između starijih i mlađih bolesnika, ali ne može se isključiti veća osjetljivost nekih starijih pojedinaca na učinak sniženja krvnog tlaka (vidjeti dio 4.2).
English: Systemic exposures to the major and minor metabolites in humans were approximately 50% and less than 1% that of azilsartan, respectively.
Croatian: Sistemska izloženost glavnom i sporednom metabolitu u ljudi iznosi približno 50% odnosno manje od 1% izloženosti azilsartanu.
English: Ipreziv at doses of 20, 40 or 80 mg has been evaluated for safety in clinical studies in patients treated for up to 56 weeks.
Croatian: Sigurnost Ipreziva u dozama 20, 40 ili 80 mg ispitana je u kliničkim ispitivanjima u bolesnika koji su bili liječeni do 56 tjedana.
English: NAME OF THE MARKETING AUTHORISATION HOLDER Takeda Logo
Croatian: ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Takeda Logo
English: These are ranked by frequency, using the following convention: very common (≥ 1/10); common (≥ 1/100, < 1/10); uncommon (≥ 1/1,000, < 1/100); rare (≥ 1/10,000, < 1/1,000); very rare (< 1/10,000), including isolated reports.
Croatian: Prikazane su prema učestalosti pomoću sljedeće konvencije: vrlo često (≥ 1/10); često (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000), uključujući izolirane prijave.
English: There is no experience with the use of Ipreziv in children or adolescents under 18 years of age.
Croatian: Nema iskustva s primjenom Ipreziva u djece ili adolescenata u dobi manjoj od 18 godina.
English: Patients with primary hyperaldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system.
Croatian: Bolesnici s primarnim hiperaldosteronizmom općenito neće imati terapijski dogovor na antihipertenzivne lijekove koji djeluju putem inhibicije reninsko-angiotenzinskog sustava.
English: For Ipreziv, olmesartan medoxomil and valsartan, respectively dizziness was observed at an incidence of 3.0%, 3.3% and 1.8%; headache at 4.8%, 5.5% and 7.6% and dyslipidemia at 3.5%, 2.4% and 1.1%.
Croatian: Zabilježena incidencija tih nuspojava uz Ipreziv, olmesartan medoksomil i valsartan iznosila je za omaglicu 3,0%, 3,3% odnosno 1,8%; za glavobolju 4,8%, 5,5% odnosno 7,6%, a za dislipidemiju 3,5%, 2,4% odnosno 1,1%.
English: The recommended starting dose is 40 mg once daily.
Croatian: Doziranje Preporučena početna doza je 40 mg jedanput na dan.
English: A thorough QT/QTc study was conducted to assess the potential of Ipreziv to prolong the QT/QTc interval in healthy subjects.
Croatian: Provedeno je temeljito ispitivanje QT/QTc da bi se procijenio mogući učinak Ipreziva na produljenje QT/QTc intervala u zdravih ispitanika.
English: There are no data from the use of Ipreziv in pregnant women.
Croatian: Nema podataka o primjeni Ipreziva u trudnica.
English: Ipreziv is indicated for the treatment of essential hypertension in adults.
Croatian: Ipreziv je indiciran za liječenje esencijalne hipertenzije u odraslih.
English: OLM-M = olmesartan medoxomil, LS = least squares, LOCF = last observation carried forward * Significant difference vs.
Croatian: OLM-M = olmesartan medoksomil, LS = najmanji kvadrati, LOCF = prijenos zadnje mjerene vrijednosti
English: Ipreziv is provided in blister packs with each blister pack having either 14 tablets or 15 tablets within cartons containing: - 14, 28, 30, 56, 90 or 98 tablets for 20 mg tablets - 14, 28, 30, 56, 90 or 98 tablets for 40 mg tablets - 14, 28, 30, 56, 90 or 98 tablets for 80 mg tablets
Croatian: Ipreziv je pakiran u blister pakiranjima sa 14 tableta ili 15 tableta unutar kutija koje sadrže: - 14, 28, 30, 56, 90 ili 98 tableta od 20 mg - 14, 28, 30, 56, 90 ili 98 tableta od 40 mg - 14, 28, 30, 56, 90 ili 98 tableta od 80 mg
English: After oral administration of azilsartan medoxomil, peak plasma concentrations (Cmax) of azilsartan are reached within 1.5 to 3 hours.
Croatian: Nakon peroralne primjene azilsartana medoksomila, vršne koncentracije azilsartana u plazmi (Cmax) postižu se u roku od 1,5 do 3 sata.
English: Like all medicines, Ipreziv can cause side effects, although not everybody gets them.
Croatian: Kao i svi drugi lijekovi, lijek Ipreziv može uzrokovati nuspojave iako se one neće javiti kod svakoga.
English: In seven double blind controlled studies, a total of 5941 patients (3672 given Ipreziv, 801 given placebo, and 1468 given active comparator) were evaluated.
Croatian: U sedam dvostruko slijepih, kontroliranih ispitivanja ukupno je bilo procijenjeno 5941 bolesnika (3672 je dobivalo Ipreziv, 801 je dobivalo placebo, a 1468 je dobivalo aktivnu kontrolu).
English: Method of administration Ipreziv is for oral use and may be taken with or without food (see section 5.2).
Croatian: Ipreziv je namijenjen za peroralnu primjenu i može se uzimati s hranom ili bez nje (vidjeti dio 5.2).
English: - Hypersensitivity to the active substance or to any of the excipients.
Croatian: - Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari.
English: Swelling of the hands, ankles or feet is more common (in less than 1 in 10 users) when Ipreziv is taken with amlodipine (a calcium channel blocker for treating hypertension) than when Ipreziv is taken alone (less than 1 in 100 users).
Croatian: Oticanje šaka, gležnjeva ili stopala češće je (u manje od 1 na 10 korisnika) kad se Ipreziv uzima s amlodipinom (blokator kalcijevih kanala za liječenje hipertenzije) nego kad se Ipreziv uzima sam (manje od 1 na 100 korisnika).
English: - have diabetes mellitus or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Croatian: - imate šećernu bolest ili oštećenu bubrežnu funkciju i liječite se lijekom za snižavanje krvnog tlaka koji sadrži aliskiren
English: Beneficial effects of Ipreziv on mortality and cardiovascular morbidity and target organ damage are currently unknown.
Croatian: Korisni učinci Ipreziva na smrtnost i kardiovaskularni pobol te oštećenje ciljnog organa trenutno nisu poznati.
English: The possibility of similar effects cannot be excluded with Ipreziv.
Croatian: Ne može se isključiti mogućnost da Ipreziv ima slične učinke.
English: A reduction in your blood pressure will be measureable within 2 weeks of initiation of treatment and the full effect of your dose will be observed by 4 weeks.
Croatian: Sniženje krvnog tlaka moći će se izmjeriti unutar 2 tjedna nakon početka liječenja, a potpuni učinak bit će vidljiv za 4 tjedna.
English: croscarmellose sodium, microcrystalline cellulose, and magnesium stearate.
Croatian: umrežena karmelozanatrij, mikrokristalična celuloza i magnezijev stearat.
English: Ipreziv is not recommended in early pregnancy, and must NOT be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Croatian: Ipreziv se ne preporučuje u ranoj trudnoći, a NE smijete ga uzimati ako ste trudni više od 3 mjeseca, jer može ozbiljno naškoditi djetetu ako ste uzima u tom razdoblju (vidjeti dio o trudnoći).
English: No data are available on the effect of Ipreziv on human fertility.
Croatian: Nema dostupnih podataka o učinku Ipreziva na plodnost u ljudi.
English: • At the request of the European Medicines Agency;
Croatian: Nadalje, nadopunjen RMP treba dostaviti: • Na zahtjev Europske agencije za lijekove;
English: Ipreziv is not recommended in early pregnancy, and must NOT be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Croatian: Ipreziv se ne preporučuje u ranoj trudnoći, a NE smijete ga uzimati ako ste trudni više od 3 mjeseca, jer može prouzročiti ozbiljna oštećenja djeteta ako se uzima nakon trećeg mjeseca trudnoće.
English: - The concomitant use of Ipreziv with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73m2) (see sections 4.5 and 5.1).
Croatian: - Istodobna primjena Ipreziv s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem bubrega (GFR < 60 ml/min/1,73 m2) (vidjeti dijelove 4.5 i 5.1).
English: Takeda Ireland Limited, Bray Business Park, Kilruddery, Co. Wicklow, Ireland
Croatian: Takeda Ireland Limited, Bray Business Park, Kilruddery, Co.
English: Azilsartan and M-II crossed the placenta and were found in the fetuses of pregnant rats and were excreted into the milk of lactating rats.
Croatian: Azilsartan i M-II prolaze kroz posteljicu i pronađeni su u fetusima skotnih ženki štakora te su bili izlučeni u mlijeko ženki štakora za vrijeme laktacije.
English: Hypovolemia should be corrected prior to administration of Ipreziv, or the treatment should start under close medical supervision, and consideration can be given to a starting dose of 20 mg.
Croatian: Prije primjene Ipreziva treba korigirati hipovolemiju ili liječenje treba započeti pod strogim medicinskim nadzorom te razmotriti davanje početne doze od 20 mg.
English: Following an oral dose of 14C-labelled azilsartan medoxomil, approximately 55% of radioactivity was recovered in feces and approximately 42% in urine, with 15% of the dose excreted in urine as azilsartan.
Croatian: Nakon peroralne doze azilsartanmedoksomila označenog izotopom 14C, približno se 55% radioaktivnosti otkrije u stolici, a približno 42% u mokraći, s time da se 15% doze izluči u mokraći kao azilsartan.
English: Following discontinuation of treatment, the majority of the elevations that had not resolved during treatment were reversible, with the creatinine levels of most subjects returning to Baseline or nearBaseline values.
Croatian: Nakon prekida liječenja, većina povišenja koja se nije povukla tijekom liječenja bila je reverzibilna i razine kreatinina su se u većine ispitanika vratile na normalne ili gotovo normalne vrijednosti.
English: This effect is also seen with other inhibitors of the renin-angiotensin-aldosterone system.
Croatian: Ovaj je učinak bio opažen i s drugim inhibitorima renin-angiotenzin-aldosteronskog sustava.
English: If you stop taking Ipreziv
Croatian: Ako ste zaboravili uzeti Ipreziv
English: If blood pressure is not adequately controlled with Ipreziv alone, additional blood pressure reduction can be achieved when Ipreziv is coadministered with other antihypertensive medicinal products, including diuretics (such as chlortalidone and hydrochlorothiazide) and calcium channel blockers (see sections 4.3, 4.4, 4.5 and 5.1).
Croatian: Ako se krvni tlak ne može na odgovarajući način kontrolirati samo Iprezivom, dodatno sniženje krvnog tlaka može se postići istovremenom primjenom Ipreziva s drugim antihipertenzivnim lijekovima, uključujući diuretike (kao što su klortalidon i hidroklorotiazid) i blokatore kalcijevih kanala (vidjeti dijelove 4.3, 4.4, 4.5 i 5.1).
English: In the repeated-dose toxicity studies, doses producing exposure comparable to that in the clinical therapeutic range caused reduced red cell parameters, changes in the kidney and renal haemodynamics, as well as increased serum potassium in normotensive animals.
Croatian: U ispitivanjima toksičnosti ponovljene doze, doze koje su izazvale izloženost usporedivu s izloženošću pri kliničkim terapijskim dozama uzrokovale su smanjenje parametara crvenih krvnih stanica i promjene u bubrezima i hemodinamici bubrega, kao i povećanje kalija u serumu u normotenzivnih životinja.
English: Additionally, Ipreziv 80 mg resulted in significantly greater reductions in SBP than the highest approved doses of olmesartan medoxomil and valsartan.
Croatian: Nadalje, Ipreziv u dozi od 80 mg značajno je više snizio krvni tlak nego najviša odobrena doza olmesartan medoksomila ili valsartana.
English: Primary End point:
Croatian: Primarni završni ishod:
English: The antihypertensive effect of Ipreziv occurred within the first 2 weeks of dosing with the full effect achieved by 4 weeks.
Croatian: Antihipertenzivni učinak Ipreziva pokazao se unutar prva 2 tjedna doziranja s time da je potpuni učinak postigao za 4 tjedna.
English: - For patients who recently have lost body fluids e.g. through vomiting or diarrhoea, or by taking water tablets, your doctor may recommend a lower starting dose of 20 mg once a day.
Croatian: - Bolesnicima koji su nedavno izgubili dio tjelesne tekućine, npr. zbog povraćanja ili proljeva ili uzimanja tableta za mokrenje, liječnik može preporučiti nižu početnu dozu od 20 mg jedanput na dan.
English: As with all other angiotensin II receptor antagonist medicines, azilsartan medoxomil may be less effective in lowering the blood pressure in black patients.
Croatian: Kao i svi drugi antagonisti receptora angiotenzina II, azilsartanmedoksomil može biti manje djelotvoran u snižavanju krvnog tlaka u bolesnika crne rase.
English: Your doctor may need to change your dose and/or to take other precautions if you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take Ipreziv” and “Warnings and precautions”).
Croatian: Liječnik će Vam možda morati promijeniti dozu i/ili poduzeti druge mjere opreza: Ako uzimate ACE inhibitor ili aliskiren (vidjeti također informacije pod naslovima
English: Based on its pharmacodynamic properties it is expected that azilsartan medoxomil would have negligible influence on the ability to drive and use machines.
Croatian: Očekuje se da će azilsartanmedoksomil, na temelju njegovih farmakodinamičkih svojstava, imati zanemariv utjecaj na sposobnost upravljanja vozilima i rada na strojevima.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being
Croatian: • Uoči svake izmjene sustava za upravljanje rizicima, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik,
English: Based on in vitro studies, carboxymethylenebutenolidase is involved in the hydrolysis in the intestine and liver.
Croatian: Na temelju ispitivanja in vitro, karboksimetilen butenolidaza uključena je u hidrolizu u crijevima i jetri.
English: As with other angiotensin II receptor antagonists and angiotensin converting enzyme inhibitors the antihypertensive effect was lower in black patients (usually a lowrenin population).
Croatian: Kao i drugi antagonisti receptora angiotenzina II i inhibitora angiotenzin-konvertirajućeg enzima, antihipertenzivni učinak bio je slabiji u bolesnika crne rase (obično u populacije s niskim reninom).
English: Doses were force-titrated at Week 2 from 20 to 40 mg and 40 to 80 mg for Ipreziv, and 20 to 40 mg and 160 to 320 mg, respectively, for olmesartan medoxomil and valsartan
Croatian: 2. Doze su bile forsirano titrirane u 2. tjednu s 20 na 40 mg i sa 40 na 80 mg za Ipreziv, sa 20 na 40 mg za olmesartan medoksomil i sa 160 na 320 mg za valsartan.
English: This medicine does not require any special temperature storage conditions.
Croatian: Lijek ne zahtjeva čuvanje na određenoj temperaturi.
English: Steady-state levels of azilsartan are achieved within 5 days and no accumulation in plasma occurs with repeated once-daily dosing.
Croatian: Stanje dinamičke ravnoteže koncentracije azilsartana postiže se u roku od 5 dana, a kod ponavnog doziranja jedanput na dan ne dolazi do nakupljanja u plazmi.