FrancophonIA/ELRC3.0 huggingface dataset:
English: Following inhalation of these doses with the Breelib the maximum plasma concentrations (Cmax) and systemic exposures (AUC (0-tlast)) increased dose-proportionally.
Slovenian: Po inhalaciji teh odmerkov z nebulatorjem Breelib so opazili, da so največje plazemske koncentracije (Cmax) in sistemska izpostavljenost (AUC (0-tlast)) povečale glede na velikost odmerka.
English: Syncope§ (see section 4.4) Hypotension*
Slovenian: Žilne bolezni vazodilatacija pordevanje sinkopa§ (glejte poglavje 4.4) hipotenzija*
English: When using the Breelib nebuliser please follow the instructions for use provided with the device.
Slovenian: Ko uporabljate nebulator Breelib, upoštevajte navodila za uporabo, priložena temu pripomočku.
English: What you need to know before you use Ventavis Do not use Ventavis
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Ventavis Ne uporabljajte zdravila Ventavis
English: It is not known whether Ventavis passes into human milk.
Slovenian: Ni znano, če zdravilo Ventavis prehaja v materino mleko.
English: Fill the medication chamber with Ventavis immediately before use.
Slovenian: Prostor za zdravilo napolnite z zdravilom Ventavis tik pred uporabo.
English: • Any Ventavis solution remaining in the nebuliser after inhalation must be thrown away (see section 5).
Slovenian: • Vso raztopino zdravila Ventavis, ki po inhalaciji ostane v nebulatorju, je treba zavreči (glejte poglavje 5).
English: It cannot be excluded that this is also relevant to humans on prolonged Ventavis therapy.
Slovenian: Ni izključeno, da to velja tudi za dolgotrajno zdravljenje z zdravilom Ventavis pri človeku.
English: In order to ensure that you receive the prescribed dose, check the colour of the medication chamber and the colour of the control disc.
Slovenian: Da boste zagotovo prejeli predpisani odmerek, preverite barvo prostora za zdravilo in barvo nadzornega diska.
English: No studies performed following inhalation.
Slovenian: Študij po inhaliranju niso izvedli.
English: In vitro (bacterial, mammalian cells, human lymphocytes) and in vivo studies (micronucleus test) for genotoxic effects have not produced any evidence for a mutagenic potential.
Slovenian: Študije genotoksičnosti in vitro (bakterijske celice, celice sesalcev in humani limfociti) in in vivo (mikronukleusni test) niso pokazale mutagenega potenciala.
English: A subgroup analysis showed that no treatment effect was observed as compared to placebo on the 6-minute walk test in the subgroup of patients with secondary pulmonary hypertension.
Slovenian: Analiza po podskupinah je pokazala, da pri podskupini s sekundarno hipertenzijo v primerjavi s placebom ni bilo opaziti učinka zdravljenja na 6-minutni test hoje.
English: Thereafter, your doctor may cautiously shorten the dosing intervals depending on how you tolerate the treatment.
Slovenian: Nato lahko zdravnik previdno skrajša intervale med posameznimi odmerki, glede na to, kako dobro prenašate zdravilo.
English: Intravenous infusion of iloprost has no effect either on the pharmacokinetics of multiple oral doses of digoxin or on the pharmacokinetics of co-administered tissue plasminogen activator (t-PA) in patients.
Slovenian: Intravenska infuzija iloprosta pri bolnikih ne vpliva na farmakokinetiko večkratnih peroralnih odmerkov digoksina, kot tudi ne na farmakokinetiko sočasno apliciranega tkivnega aktivatorja plazminogena (t-PA).
English: Inhaled iloprost (or placebo) was added to patients' current therapy, which could include a combination of anticoagulants, vasodilators (e.g. calcium channel blockers), diuretics, oxygen, and digitalis, but not PGI2 (prostacyclin or its analogues).
Slovenian: Inhalacijski iloprost (ali placebo) je bil dodan bolnikovemu takratnemu zdravljenju, ki je lahko vključevalo kombinacijo antikoagulantov, vazodilatatorjev (npr. zaviralci kalcijevih kanalčkov), diuretikov, kisika in digitalisa, ne pa tudi PGI2 (prostaciklina ali njegovih analogov).
English: Although, clinical studies have not been conducted, in vitro studies investigating the inhibitory potential of iloprost on the activity of cytochrome P450 enzymes revealed that no relevant inhibition of drug metabolism via these enzymes by iloprost is to be expected.
Slovenian: Čeprav kliničnih študij niso opravljali, so študije in vitro, v katerih so proučevali zaviralne lastnosti iloprosta na delovanje encimov citokroma P450, pokazale, da zaradi iloprosta ni pričakovati pomembnejšega zaviralnega učinka teh encimov na presnovo zdravil.
English: The most serious adverse reactions were hypotension, bleeding events, and bronchospasm.
Slovenian: Najresnejši neželeni učinki so bili hipotenzija, krvavitve in bronhospazem.
English: No disturbance of post-natal development and reproductive performance was seen in animals exposed during lactation.
Slovenian: Motenj postnatalnega razvoja in sposobnosti razmnoževanja pri živalih, ki so bile učinkovini izpostavljene med dojenjem, niso opazili.
English: • talk to your doctor
Slovenian: • se posvetujte z zdravnikom.
English: The ready-to-use Ventavis nebuliser solution is administered with a suitable inhalation device (nebuliser) (see below and section 6.6).
Slovenian: Za uporabo pripravljeno zdravilo Ventavis inhalacijska raztopina za nebulator se uporablja z ustreznim pripomočkom za inhaliranje (nebulatorjem) (glejte spodaj in poglavje 6.6).
English: • The other ingredients are trometamol, ethanol, sodium chloride, hydrochloric acid for pH adjustment, and water for injections.
Slovenian: • Druge sestavine so trometamol, etanol, natrijev klorid, klorovodikova kislina za uravnavanje vrednosti pH in voda za injekcije.
English: Within 30 minutes to 2 hours after the end of inhalation, iloprost is not detectable in the central compartment (limit of quantification 25 picogram/ml).
Slovenian: V 30 minutah do 2 urah po končani inhalaciji iloprost v osrednjem prostoru ni več zaznaven (meja kvantifikacije:
English: In addition to local effects resulting from administration of iloprost by inhalation such as cough, adverse reactions with iloprost are related to the pharmacological properties of prostacyclins.
Slovenian: Poleg lokalnih učinkov npr. kašelj, ki so posledica inhaliranega iloprosta, so neželeni učinki iloprosta povezani s farmakološkimi lastnostmi prostaciklinov.
English: Ventavis inhibits unwanted blocking or narrowing of blood vessels and allows more blood to flow through the vessels.
Slovenian: Zdravilo Ventavis preprečuje nastanek neželene zapore ali zoženje krvnih žil in omogoča večji pretok krvi skozi žile.
English: It is not known whether iloprost/metabolites are excreted in human breast milk.
Slovenian: Ni znano, ali se iloprost/presnovki izločajo v materino mleko.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Slovenian: • Redno posodobljena poročila o varnosti zdravila (PSUR) Zahteve glede predložitve redno posodobljenega poročila o varnosti zdravila za to zdravilo so določene v seznamu referenčnih datumov EU (seznamu EURD), opredeljenem v členu 107c(7)
English: The efficacy and tolerability of inhaled iloprost when administered with other nebulising systems, which provide different nebulisation characteristics of iloprost solution, have not been established.
Slovenian: Učinkovitost in prenašanje inhaliranega iloprosta pri uporabi drugih nebulatorjev, ki dajejo raztopini iloprosta drugačne pršilne lastnosti, nista dokazani.
English: − Pulmonary hypertension due to venous occlusive disease.
Slovenian: - pljučna hipertenzija zaradi venske okluzivne bolezni
English: • Medicines used to treat high blood pressure or heart disease, such as beta blockers, nitro-vasodilators,
Slovenian: • zdravila za zdravljenje visokega krvnega tlaka ali bolezni srca, kot so antagonisti adrenergičnih receptorjev beta,
English: Only expected pharmacological effects like hypotension, reddening of skin, dyspnoea, increased intestinal motility were observed.
Slovenian: Opazili so le pričakovane farmakološke učinke, kot so hipotenzija, pordelost kože, dispneja in povečana črevesna peristaltika.
English: In case of interruption of Ventavis therapy, the risk of rebound effect is not formally excluded.
Slovenian: V primeru prekinitve zdravljenja z zdravilom Ventavis se tveganja za pojav sekundarnih učinkov ne more izključiti.
English: • if you have a heart problem, such as poor blood flow to the heart muscles (severe coronary heart disease or unstable angina).
Slovenian: • če imate težave s srcem, kot so slaba prekrvitev srčne mišice (huda koronarna srčna bolezen ali nestabilna angina pektoris).
English: Ventavis inhalation might entail the risk of inducing bronchospasm, especially in patients with bronchial hyperactivity (see section 4.8).
Slovenian: Bolniki z boleznimi dihal Zdravilo Ventavis lahko povzroči tveganje za pojav bronhospazma, predvsem pri bolnikih z bronhialno hiperaktivnostjo (glejte poglavje 4.8).
English: Follow carefully the instructions that come with the nebuliser especially the instructions on hygiene and cleaning of the nebuliser.
Slovenian: Natančno upoštevajte navodila, priložena nebulatorju, predvsem navodila za vzdrževanje in čiščenje nebulatorja.
English: Physicians should be alerted to the presence of concomitant conditions or medicinal products that might increase the risk of hypotension and syncope (see section 4.5).
Slovenian: Zdravniki morajo biti pozorni na prisotnost sočasnih bolezni ali sočasno jemanje zdravil, ki lahko povečajo tveganje za pojav hipotenzije in sinkope (glejte poglavje 4.5).
English: What Ventavis is and what it is used for What you need to know before you use Ventavis How to use Ventavis
Slovenian: Kaj je zdravilo Ventavis in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Ventavis Kako uporabljati zdravilo Ventavis
English: • widening of the blood vessels (vasodilatation).
Slovenian: • razširjene krvne žile (vazodilatacija).
English: • if your pulmonary hypertension is due to a blocked or narrowed vein (venous occlusive disease).
Slovenian: • če je pri vas pljučna hipertenzija posledica zaprte ali zožene vene (venska okluzivna bolezen).
English: The baseline 6-minute walk test values reflected a moderate exercise limitation: in the iloprost group the mean was 332 metres (median value: 340 metres) and in the placebo group the mean was 315 metres (median value: 321 metres).
Slovenian: minutnega testa hoje so pokazale zmerno omejitev telesne dejavnosti: v skupini, ki je prejemala iloprost, je bilo povprečje 332 metrov (mediana vrednost: 340 metrov), medtem, ko je bilo v skupini, ki je prejemala placebo, povprečje 315 metrov (mediana vrednost: 321 metrov).
English: The active substance of Ventavis is iloprost.
Slovenian: Učinkovina zdravila Ventavis je iloprost.
English: • Swelling, mainly of the ankles and legs, due to fluid retention (peripheral oedema) is a very common symptom of the illness itself but can also occur during treatment with Ventavis.
Slovenian: Drugi možni učinki • otekanje, predvsem gležnjev in nog, zaradi zastajanja tekočine (periferni edem) je zelo pogost simptom bolezni same, vendar se lahko pojavi tudi med zdravljenjem z zdravilom Ventavis.
English: • Inhibition of platelet aggregation, platelet adhesion and release reaction
Slovenian: • zaviranje agregacije in adhezije trombocitov ter reakcij sproščanja,
English: Your doctor will consider changing your treatment.
Slovenian: Zdravnik se bo morda odločil za spremembo zdravljenja.
English: Contents of the pack and other information What Ventavis contains:
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Ventavis
English: Other possible effects
Slovenian: Možni neželeni učinki
English: The measured MMAD of the aerosol droplets was 2.6 micrometres.
Slovenian: Izmerjeni MMAD kapljic aerosola je bil 2,6 mikrometra.
English: • Bleeding events (mostly nosebleed (epistaxis) and coughing up blood (haemoptysis)) may very commonly occur, especially if you are also taking blood-thinning medicines (anticoagulants).
Slovenian: • Zelo pogosto se lahko pojavijo krvavitve (večinoma krvavitve iz nosu (epistaksa) in izkašljevanje krvi iz dihal (hemoptiza)), predvsem če sočasno jemljete tudi zdravila za redčenje krvi (antikoagulante).
English: One inhalation session with Breelib will usually last about 3 minutes.
Slovenian: Posamezna inhalacija z nebulatorjem Breelib običajno traja 3 minute.
English: No clinical trial data are available comparing directly in intra-patient observations the acute haemodynamic response after intravenous to that after inhaled iloprost.
Slovenian: Ni podatkov o kliničnih preskušanjih, v katerih bi pri bolnikih neposredno primerjali akutni hemodinamični odziv po intravenski in inhalacijski uporabi iloprosta.
English: The mean clearance of iloprost is estimated to be 10 ml/minute/kg.
Slovenian: Ocenjeni povprečni očistek iloprosta je približno 10 ml/min/kg.
English: Excipients: trometamol, ethanol 96%, sodium chloride, hydrochloric acid (for pH adjustment), water for injections.
Slovenian: trometamol, etanol 96 %, natrijev klorid, klorovodikova kislina (za uravnavanje vrednosti pH), voda za injekcije.
English: One inhalation session with Venta-Neb will usually last about 4 to 10 minutes depending on the prescribed dose.
Slovenian: Posamezna inhalacija z nebulatorjem Venta-Neb traja običajno 4 do 10 minut, odvisno od predpisanega odmerka.
English: 4.2 Posology and method of administration Drug product
Slovenian: 4.2 Odmerjanje in način uporabe Zdravilo
English: − Congenital or acquired valvular defects with clinically relevant myocardial function disorders not related to pulmonary hypertension.
Slovenian: - prirojene ali pridobljene okvare zaklopk s klinično pomembno motnjo v delovanju srca, ki ni v povezavi s pljučno hipertenzijo
English: Fatal cases included cerebral and intracranial haemorrhage.
Slovenian: Med smrtnimi primeri so bile tudi smrti zaradi cerebralne in intrakranialne krvavitve.
English: • mouth and tongue irritation including pain
Slovenian: • neprijeten občutek v ustih in jeziku, tudi bolečine
English: The metabolites are eliminated from plasma and urine in 2 phases, for which half-lives of about 2 and 5 hours (plasma) and 2 and 18 hours (urine) have been calculated.
Slovenian: Presnovki se iz plazme in seča izločajo v dveh fazah, za kateri sta izračunana razpolovna časa približno 2 in 5 ur
English: Ventavis10 microgram/ml is available in the following packs:
Slovenian: Zdravilo Ventavis 10 mikrogramov/ml je na voljo v naslednjih pakiranjih:
English: 2.5 mcg red red
Slovenian: 2,5 mikrogramov rdeč rdeč
English: For administration with the Breelib or the I-Neb.
Slovenian: Za uporabo z nebulatorjem Breelib ali I-Neb.
English: • Inhaling Ventavis might trigger breathing difficulties (see section 4), especially in patients with bronchospasm (sudden constriction of the muscles in the walls of the small airways) and wheezing.
Slovenian: • Vdihavanje zdravila Ventavis lahko povzroči težave z dihanjem (glejte poglavje 4), predvsem pri bolnikih, ki imajo bronhospazem (nenaden krč mišic v steni majhnih dihalnih poti) in so zasopli.
English: No disturbance of postnatal development and reproductive performance was seen in the offspring that were raised, indicating that the observed retardation in rats was compensated during the postnatal development.
Slovenian: Pri mladičih niso opazili motenj v postnatalnem razvoju in sposobnosti razmnoževanja, kar kaže, da je ta zastoj v rasti pri podganah nadomeščen v postnatalnem razvoju.
English: In addition, instructions for hygiene and cleaning of the nebulisers provided by the device manufacturers should be followed carefully.
Slovenian: Dodatno je treba skrbno upoštevati tudi navodila za vzdrževanje in čiščenje nebulatorja, ki so priložena nebulatorju.
English: Contact of Ventavis with skin or swallowing Ventavis
Slovenian: Stik zdravila Ventavis s kožo ali zaužitje zdravila Ventavis
English: Frequently observed symptoms following overdose are dizziness, headache, flushing, nausea, jaw pain or back pain.
Slovenian: Pogosto opaženi simptomi po prevelikem odmerjanju so omotica, glavobol, pordevanje, navzea,bolečine v čeljusti ali bolečine v hrbtu.
English: • For the inhalation you should use a mouthpiece to prevent Ventavis coming into contact with your skin.
Slovenian: • Pri vdihavanju uporabite ustnik, da preprečite stik zdravila Ventavis s kožo.
English: For further details please refer to the instruction manual of the nebuliser device or ask your doctor.
Slovenian: Za podrobnosti glejte navodilo za uporabo nebulatorja ali se posvetujte z zdravnikom.
English: • Fainting (syncope) is a symptom of the illness itself but can also occur during treatment with Ventavis (see also section 2 “Warnings and precautions”, for advice on what you can do to avoid this).
Slovenian: • omedlevica (sinkopa) je najpogostejši simptom bolezni same, vendar se lahko pojavi tudi med zdravljenjem z zdravilom Ventavis (za nasvete o tem, kako se lahko temu izognete, glejte tudi poglavje 2 »Opozorila in previdnostni ukrepi«).
English: For filling please follow the instructions for use of the nebuliser.
Slovenian: Pri polnjenju upoštevajte navodila za uporabo nebulatorja.
English: Data with intravenously administered iloprost indicated that the elimination is reduced in patients with renal failure requiring dialysis.
Slovenian: Podatki o intravenski uporabi iloprosta kažejo, da je izločanje zmanjšano pri bolnikih z odpovedjo ledvic, ki potrebujejo zdravljenje z dializo.
English: Ventavis nebuliser solution should not come into contact with skin and eyes; oral ingestion of Ventavis solution should be avoided.
Slovenian: Zdravilo Ventavis inhalacijska raztopina za nebulator ne sme priti v stik s kožo in očmi; izogibati se je treba peroralnemu zaužitju zdravila Ventavis inhalacijska raztopina za nebulator.
English: Ventavis has major influence on the ability to drive and use machines for patients experiencing hypotensive symptoms such as dizziness.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja strojev Zdravilo Ventavis ima pomemben vpliv na sposobnost vožnje in upravljanja strojev pri bolnikih s simptomi hipotenzije, kot je omotica.
English: mouthpiece and 1 medication chamber).
Slovenian: (1 ustnik in 1 prostor za zdravilo)
English: In a small, randomised, 12-week double-blinded, placebo-controlled study (the STEP trial), 34 patients treated with bosentan 125 mg twice per day for at least 16 weeks who were in stable haemodynamic conditions before enrolment, tolerated the addition of inhaled iloprost at the concentration of 10 microgram/ml (up to 5 microgram 6 to 9 times per day during waking hours).
Slovenian: V majhni, randomizirani, 12 tednov trajajoči, dvojno slepi, s placebom nadzorovani študiji (STEP študija) so pri 34 bolnikih, ki so se zdravili s 125 mg bosentana dvakrat na dan vsaj 16 tednov in so bili pred vključitvijo v preskušanje v stabilnem hemodinamskem stanju, ugotavljali prenašanje dodajanja iloprosta v obliki inhalacij v koncentraciji 10 mikrogramov/ml (do 5 mikrogramov iloprosta
English: The primary efficacy endpoint defined for this study, was a combined response criterion consisting of improvement in exercise capacity (6-minute walk test) at 12 weeks by at least 10% versus baseline, and improvement by at least one NYHA class at 12 weeks versus baseline, and no deterioration of pulmonary hypertension or death at any time before 12 weeks.
Slovenian: V tej študiji je bila primarna učinkovitost opredeljena kot kombinacija kriterijev odziva, ki jo sestavljajo izboljšanje telesne zmogljivosti (6-minutni test hoje) po 12 tednih za najmanj 10 % v primerjavi z izhodiščno vrednostjo in izboljšanje za vsaj en razred po klasifikaciji
English: Further in vitro studies suggest that metabolism of iloprost in the lungs is similar after intravenous administration or inhalation.
Slovenian: Nadaljnji izsledki in vitro študij kažejo, da je presnova iloprosta v pljučih po intravenski ali inhalacijski uporabi podobna.
English: Since iloprost inhibits platelet function its use with the following substances may enhance iloprostmediated platelet inhibition, thereby increasing the risk of bleeding:
Slovenian: Ker iloprost zavira delovanje trombocitov, lahko njegova uporaba z naslednjimi učinkovinami okrepi z iloprostom posredovano zaviranje trombocitov in tako poveča tveganje za krvavitev:
English: Just before you start to inhale, break the glass ampoule and pour the solution into the medication chamber following the instructions for use of the nebuliser.
Slovenian: Tik pred začetkom inhaliranja prelomite stekleno ampulo in raztopino zlijte v prostor za zdravilo v skladu z navodili za uporabo nebulatorja.
English: Continuous intravenous/subcutaneous infusion of iloprost up to 26 weeks in rodents and non-rodents did not cause any organ toxicity at dose levels which exceeded the human therapeutic systemic exposure between 14 and 47 times (based on plasma levels).
Slovenian: 26 tednov, ni povzročilo organske toksičnosti pri odmerkih, ki so od 14- do 47-krat presegali sistemsko terapevtsko izpostavljenost pri človeku (glede na plazemske koncentracije).
English: If you tend to experience fainting episodes, avoid any exceptional straining, for example during physical exertion; it might be useful to inhale Ventavis before.
Slovenian: Če se vam omedlevice pojavljajo pogosto, se izogibajte izjemnim naporom, na primer med telesnimi obremenitvami; morda bo pomagalo, če zdravilo Ventavis vdihnete pred telesnimi obremenitvami.
English: Ventavis is intended for inhalation use by nebulisation.
Slovenian: Zdravilo Ventavis je namenjeno za inhaliranje z nebulatorjem.
English: Newborns, infants and pregnant women should not be subjected to Ventavis in the room air.
Slovenian: Novorojenci, dojenčki in nosečnice ne smejo biti izpostavljeni zdravilu Ventavis v zraku prostora.
English: The total clearance of iloprost is about 20 ml/kg/min, which indicates extrahepatic contribution to the metabolism of iloprost.
Slovenian: Celotni očistek iloprosta je približno 20 ml/kg/min, kar kaže na ekstrahepatično presnovo iloprosta.
English: − Severe arrhythmias.
Slovenian: - hude aritmije
English: Serum glucose levels
Slovenian: Vrednosti glukoze v serumu
English: Switching to the Breelib nebuliser
Slovenian: Prehod na nebulator Breelib
English: Direct vasodilatation of the pulmonary arterial bed occur with consecutive significant improvement of pulmonary artery pressure, pulmonary vascular resistance and cardiac output as well as mixed venous oxygen saturation.
Slovenian: Farmakološki učinki po inhaliranju zdravila Ventavis Po neposredni vazodilataciji pljučnega arterijskega povirja pride do značilnega izboljšanja arterijskega tlaka in vaskularne rezistence v pljučih, kot tudi do izboljšanja srčne zmogljivosti in zasičenosti venske krvi s kisikom.
English: In a study with intravenous infusion of iloprost, patients with end-stage renal failure undergoing intermittent dialysis treatment are shown to have a significantly lower clearance (mean CL = 5 ± 2 ml/minute/kg) than that observed in patients with renal failure not undergoing intermittent dialysis treatment (mean CL = 18 ± 2 ml/minute/kg).
Slovenian: Študije z intravensko infuzijo iloprosta kažejo, da imajo bolniki z odpovedjo ledvic, ki se zdravijo z intermitentno dializo, značilno manjši očistek (povprečni očistek = 5 ± 2 ml/min/kg) kot bolniki z okvaro ledvic, ki se ne zdravijo z dializo (povprečni očistek = 18 ± 2 ml/min/kg).
English: • pain when swallowing (pharyngolaryngeal irritation)
Slovenian: • bolečine pri požiranju (faringolaringealno draženje)
English: You may be gradually introduced to the prescribed dose or be prescribed a lower dose of Ventavis than for other patients (see section 3.
Slovenian: Morda vam bo predpisani odmerek uvajal postopoma ali vam predpisal manjši odmerek zdravila Ventavis kot pri drugih bolnikih (glejte poglavje 3, »Kako uporabljati zdravilo Ventavis«).
English: Bayer HealthCare Tél(N° vert): +33-(0)800 87 54 54
Slovenian: Tél(N° vert): +33-(0)800 87 54 54