FrancophonIA/ELRC3.0 huggingface dataset:
English: • Caution should be exercised in patients on 5- or 8-methoxypsoralen (5 and 8-MOP), which increases melatonin levels by inhibiting its metabolism.
Danish: • Der skal udvises forsigtighed hos patienter, der tager 5- eller 8-methoxypsoralen (5- og 8MOP), som øger melatoninniveauerne, da disse stoffer hæmmer omsætningen af melatonin.
English: • Melatonin's metabolism is mainly mediated by CYP1A enzymes.
Danish: • Melatonin omsættes hovedsagligt af CYP1A-enzymer.
English: The liver is the primary site of melatonin metabolism and therefore, hepatic impairment results in higher endogenous melatonin levels.
Danish: Melatonin metaboliseres primært i leveren, og derfor medfører nedsat leverfunktion højere endogene melatoninniveauer.
English: What you need to know before you take Circadin
Danish: Det skal du vide, før du begynder at tage Circadin
English: Excipient with known effect: each prolonged-release tablet contains 80 mg lactose monohydrate.
Danish: Hjælpestof med kendt effekt, som behandleren skal være opmærksom på: Hver depottablet indeholder 80 mg lactosemonohydrat.
English: Therefore, interactions between melatonin and other active substances as a consequence of melatonin's effect on CYP1A enzymes are not likely to be significant.
Danish: Det er derfor ikke sandsynligt, at der er interaktioner mellem melatonin og andre aktive stoffer på grund af melatonins indvirkning på CYP1A-enzymer.
English: Circadin is used on its own for the short-term treatment of primary insomnia (persistent difficulty in getting to sleep or staying asleep, or poor quality of sleep) in patients aged 55 years and older.
Danish: Circadin anvendes som monoterapi (et enkelt lægemiddel) til korttidsbehandling af primær søvnløshed (vedvarende vanskelighed ved at falde i søvn eller blive ved med at sove eller dårlig søvnkvalitet) hos patienter i alderen 55 år og derover.
English: Name and address of the manufacturers responsible for batch release
Danish: Navn og adresse på fremstillerene ansvarlige for batchfrigivelse
English: Each prolonged-release tablet contains 2 mg melatonin.
Danish: Hver depottablet indeholder 2 mg melatonin.
English: Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible.
Danish: Der kan derfor forekomme interaktioner mellem melatonin og andre aktive stoffer som følge af de andre stoffers indvirkning på CYP1Aenzymer.
English: Crushing or chewing should not be used to facilitate swallowing.
Danish: Tabletterne bør ikke knuses eller tygges for at lette indtagelsen.
English: Immune system disorders
Danish: Immunsystem sygdomme
English: − Adrenergic agonists/antagonists (such as certain types of medicines used to control blood pressure by constricting blood vessels, nasal decongestants, blood pressure lowering medicines), opiate agonists/antagonists (such as medicinal products used in the treatment of drug addiction), prostaglandin inhibitors (such as nonsteroidal anti-inflammatory medicines), antidepressant medication, tryptophan and alcohol.
Danish: - Adrenerge agonister/antagonister (som fx. visse typer medicin, der bruges til at kontrollere blodtrykket ved at indsnævre blodkarrene, midler mod tilstoppet næse, blodtrykssænkende medicin), opiate agonister/antagonister (som fx ikke-steroide anti-inflammatoriske lægemidler), antidepressive midler, tryptophan og alkohol.
English: It is also associated with a hypnotic effect and increased propensity for sleep.
Danish: Melatonin associeres også med en hypnotisk og søvnfremmende virkning.
English: For melatonin, no clinical data on exposed pregnancies are available.
Danish: Der foreligger ikke kliniske data om eksponering for melatonin under graviditet.
English: However, no pharmacodynamic differences between males and females were found despite differences in blood levels.
Danish: Der er observeret op til 5 gange forskel på Cmax mellem personer af samme køn.Der er dog ikke fundet farmakodynamiske forskelle mellem mænd og kvinder trods forskelle i melatoninniveauerne.
English: Patients with rare hereditary problems of galactose intolerance, the LAPP lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Danish: Dette præparat bør ikke anvendes til patienter med arvelig galactoseintolerans, en særlig form af hereditær lactasemangel (Lapp Lactase deficiency) eller glucose/galactosemalabsorption.
English: A slight effect on post-natal growth and viability was found in rats only at very high doses, equivalent to approximately 2000 mg/day in humans.
Danish: Hos rotter blev der ved meget høje doser, svarende til cirka 2000 mg/dag hos mennesker, fundet en mindre påvirkning af den postnatale udvikling.
English: In addition, patients' self-reported quality of sleep, number of awakenings and morning alertness significantly improved with Circadin compared to placebo.
Danish: Desuden var patienternes rapporterede søvnkvalitet, antal opvågninger og årvågenhed om morgenen signifikant forbedre i Circadin-gruppen sammenlignet med placebogruppen.
English: MEDICE Arzneimittel Pütter GmbH & Co. KG Tel.: + 48-(0)22 642 2673 e-mail: office@medice.pl
Danish: KG Tel.: + 48-(0)22 642 2673 e-mail: office@medice.pl
English: The most common adverse reactions were headache, nasopharyngitis, back pain, and arthralgia, which were common, by MedDRA definition, in both the Circadin and placebo treated groups.
Danish: De hyppigste bivirkninger hos både de Circadin- og de placebobehandlede grupper var hovedpine, nasopharyngitis, rygsmerte og artralgi, som var almindelige ifølge MedDRA-definitionen.
English: patients in the active group and by 77% in the placebo group.
Danish: Bivirkninger fremkommet ved behandlingen blev rapporteret af 85 % af patienterne i den aktive gruppe og af 77 % i placebogruppen.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 2 mg melatonin.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver tablet indeholder 2 mg melatonin.
English: • Caution should be exercised in patients on cimetidine a CYP2D inhibitor, which increases plasma melatonin levels, by inhibiting its metabolism.
Danish: • Der skal udvises forsigtighed hos patienter, der tager cimetidin, som er en CYP2D-hæmmer, der øger melatoninniveauerne i plasma ved at hæmme omsætningen af melatonin.
English: In a polysomnographic (PSG) study with a run-in of 2 weeks (single-blind with placebo treatment), followed by a treatment period of 3 weeks (double-blind, placebo-controlled, parallel group design) and a 3-week withdrawal period, sleep latency (SL) was shortened by 9 minutes compared to placebo.
Danish: I en polysomnografisk (PSG) undersøgelse med en indkøringsperiode på to uger (enkeltblind, placebokontrolleret) efterfulgt af en behandlingsperiode på tre uger (dobbeltblind, placebokontrolleret, parallelgruppedesign) og en tre ugers nedtrapningsperiode blev søvnlatensen (SL) forkortet med ni minutter sammenlignet med placebo.
English: In addition, quality of sleep and morning alertness significantly improved with Circadin compared to placebo.
Danish: Desuden forbedredes søvnkvaliteten og årvågenheden om morgenen signifikant i Circadin-gruppen sammenlignet med placebo-gruppen.
English: There is no experience of the use of Circadin in patients with liver impairment.
Danish: Der findes ingen erfaring med anvendelse af Circadin til patienter med nedsat leverfunktion.
English: Temmler Pharma GmbH & Co. KG Temmlerstrasse 2
Danish: Temmler Pharma GmbH & Co.
English: • CYP1A2 inhibitors such as quinolones may give rise to increased melatonin exposure.
Danish: • CYP1A2-hæmmere såsom quinoloner kan medføre øgede plasmakoncentrationer af melatonin.
English: No studies on the use of Circadin in people with liver or kidney diseases have been performed, you should speak to your doctor before taking Circadin as its use is not recommended.
Danish: Der er ikke gennemført undersøgelser af brugen af Circadin hos personer med lever- eller nyresygdomme, du bør tale med din læge, før du tager Circadin, da det ikke kan anbefales at anvende det. - Hvis du har fået at vide af din læge, at du har en intolerans over for visse sukkerarter.
English: Therefore, breast-feeding is not recommended in women under treatment with melatonin.
Danish: Kvinder, der er i behandling med melatonin, frarådes derfor at amme.
English: What Circadin looks like and contents of the pack Circadin 2 mg prolonged-release tablets are available as white to off-white round bi-convex shaped tablets.
Danish: Circadin 2 mg depottabletter fås som hvide til off-white, runde, bikonvekse tabletter.
English: A Paediatric study (n=125) with doses of 2, 5 or 10 mg prolonged-release melatonin in multiples of 1 mg minitablets (age-appropriate pharmaceutical form), with two week run in baseline period on placebo and a randomised, double blind, placebo controlled, parallel group treatment period of 13 weeks, demonstrated an improvement in total sleep time (TST) after 13 weeks of double-blind treatment; participants slept more with active treatment (508 minutes), compared to placebo
Danish: Et pædiatrisk studie (n=125) med doser på 2, 5 eller 10 mg depot melatonin i multipler af 1 mg minitabletter (alderssvarende farmaceutisk formulering) med to ugers baseline-indkøringsperiode på placebo og en randomiseret, dobbeltblind, placebokontrolleret, parallelgruppe behandlingsperiode på 13 uger, påviste en forbedring i total sovetid (total sleep time, TST) efter 13 uger med dobbeltblind behandling.
English: • Melatonin does not induce CYP1A enzymes in vitro at supra-therapeutic concentrations.
Danish: • Melatonin inducerer ikke CYP1A in vitro ved supraterapeutiske koncentrationer.
English: Hepatic enzyme increased, blood electrolyes abnormal, laboratory test abnormal
Danish: Undersøgelser abnorm leverfunktionstest, vægtforøgelse forhøjet leverenzym, abnorme blodelektrolytter, abnorm laboratorietest
English: Therefore, Circadin is not recommended for use in patients with autoimmune diseases.
Danish: Circadin bør derfor ikke bruges til patienter med autoimmunsygdomme.
English: Ammonio methacrylate copolymer type B Calcium hydrogen phosphate dihydrate Lactose monohydrate Silica, colloidal anhydrous Talc
Danish: Ammoniummethacrylat copolymer (type B) Calciumhydrogenphosphatdihydrat Lactosemonohydrat
English: If you get any side effects, talk to your doctor or pharmacist.
Danish: Hvis du får oplever bivirkninger, bør du tale med din læge, sygeplejerske eller apoteket.
English: Experimental data suggest that isoenzymes CYP1A1, CYP1A2 and possibly CYP2C19 of the cytochrome P450 system are involved in melatonin metabolism.
Danish: Eksperimentelle data tyder på, at cytokrom P450-systemet er involveret i melatoninmetabolismen via isoenzymerne CYP1A1, CYP1A2 og muligvis CYP2C19.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 29 June 2007
Danish: DATO FOR FØRSTE MARKEDSFØRINGSTILLADELSE/FORNYELSE AF TILLADELSEN
English: Irritability, nervousness, restlessness, insomnia, abnormal dreams, nightmares, anxiety, migraine, headache, lethargy (tiredness, lack of energy), restlessness associated with increased activity, dizziness, tiredness, high blood pressure, upper abdominal pain, indigestion, mouth ulceration, dry mouth, nausea, changes in the composition of your blood which could cause yellowing of the skin or eyes, inflammation of the skin, night sweats, itching, rash, dry skin, pain in extremities, menopausal symptoms, feeling of weakness, excretion of glucose in the urine, excess proteins in the urine, abnormal liver function and weight increase.
Danish: Irritabilitet, nervøsitet, rastløshed, søvnløshed, abnorme drømme, mareridt, angst, migræne, hovedpine, letargi (træthed, mangel på energi), rastløshed i forbindelse med øget aktivitet, svimmelhed, døsighed, forhøjet blodtryk, mavepine, fordøjelsesbesvær, mundsår, mundtørhed, kvalme, forandringer i sammensætningen af dit blod, som kan medføre, at huden eller det hvide i øjnene bliver farvet gul, betændelse i huden, natlige svedeture, kløe, udslæt, tør hud, smerter i arme og ben, symptomer på overgangsalder, følelse af svaghed, udskillelse af glukose i urinen, for meget protein i urinen, unormal leverfunktion og vægtforøgelse.
English: Shingles, high level of fatty molecules in the blood, low serum calcium levels in the blood, low sodium levels in the blood, altered mood, aggression, agitation, crying, stress symptoms, early morning awakening, increased sex drive, depressed mood, memory impairment, disturbance in attention, dreamy state, restless legs syndrome, poor quality sleep, ‘pins and needles' feeling, watery eyes, dizziness when standing or sitting, hot flushes, acid reflux, stomach disorder, blistering in the mouth, tongue ulceration, stomach upset, vomiting, abnormal bowel sounds, wind, excess saliva production, bad breath, abdominal discomfort, gastric disorder, inflammation of the stomach lining, eczema, skin rash, hand dermatitis, itchy rash, nail disorder, arthritis, muscle spasms, neck pain, night cramps, prolonged erection that might be painful, inflammation of the prostate gland, tiredness, pain, thirst, passing large volumes of urine, urinating during the night, increased liver enzymes, abnormal blood electrolytes and abnormal laboratory tests.
Danish: Helvedesild, et højt niveau af fedt i blodet, lave niveauer af kalcium i blodet, lave niveauer af natrium i blodet, humørændringer, aggression, rastløs uro, gråd, stresssymptomer, tidlig opvågning om morgenen, øget sexlyst, nedtrykt sindstilstand, nedsat hukommelse, opmærksomhedsforstyrrelse, drømmende sindstilstand, uro i benene, dårlig søvnkvalitet, en prikkende og stikkende fornemmelse i huden, rindende øjne, svimmelhed i stående eller siddende stilling, hedeture, halsbrand og sure opstød, maveproblemer, blister i munden, sårdannelse på tungen, mavebesvær, opkastning, unormale tarmlyde, luft fra tarmen, overdreven spytdannelse, dårlig ånde, mavebesvær, lidelse i mavesækken, betændelse i mavesækken, eksem, hududslæt, udslæt på hænderne, kløende udslæt, negleproblemer, ledsmerter, muskelkramper, nakkesmerter, nattekramper, forlænget erektionsvarighed, hvilket kan være smertefuldt, betændelse i blærehalskirtlen, træthed, smerter, tørst, voldsom vandladning, natlig vandladning, forhøjede leverenzymer, unormale blodelektrolytter og unormale laboratorieprøver.
English: • CYP1A2 inducers such as carbamazepine and rifampicin may give rise to reduced plasma concentrations of melatonin.
Danish: • Carbamazepin og rifampicin inducerer CYP1A2, hvilket kan medføre nedsatte plasmakoncentrationer af melatonin.
English: Package Leaflet: Information for the patient Circadin 2 mg prolonged-release tablets Melatonin
Danish: Indlægsseddel: Information til patienten Circadin 2 mg depottabletter Melatonin
English: Circadin with food, drink and alcohol
Danish: Brug af Circadin sammen med mad, drikke og alkohol Tag Circadin efter, at du har spist.
English: Hypertriglyceridaemia, hypocalcaemia, hyponatraemia
Danish: Metabolisme og ernæring hypertriglyceridæmi, hypokalcæmi, hyponatriæmi
English: Asthenia, chest pain Fatigue, pain, thirst
Danish: Angioødem, mundødem, tungeødem
English: Caution should be used when melatonin is administered to such patients.
Danish: Der bør udvises forsigtighed, når melatonin administreres til patienter med nedsat nyrefunktion uanset graden.
English: In a second outpatient study with two week run in baseline period with placebo and a randomised, double blind, placebo controlled, parallel group treatment period of 3 weeks, the rate of patients who showed a clinically significant improvement in both quality of sleep and morning alertness was 26% in the Circadin group as compared to 15% in the placebo group.
Danish: I et andet forsøg med ambulante patienter med to ugers baseline-indkøringsperiode (placebokontrolleret) og en randomiseret, dobbeltblind, placebokontrolleret, parallelgruppe behandlingsperiode på tre uger var andelen af patienter, der viste en klinisk effekt i såvel søvnkvalitet som årvågenhed om morgenen 26 % i Circadin-gruppen sammenlignet med 15 % i placebo-gruppen.
English: MEDICE Arzneimittel Pütter GmbH & Co. KG Tel: +49 (0)2371 9370 info@medice.de
Danish: KG Tel: +49 (0)2371 9370 info@medice.de
English: Circadin contains lactose monohydrate.
Danish: Circadin indeholder lactosemonohydrat.
English: This leaflet was last revised in { month/YYYY}.
Danish: Denne indlægsseddel blev senest ændret den (måned ÅÅÅÅ) Andre informationskilder
English: No studies on the use of Circadin in people with auto-immune diseases have been performed; therefore, you should speak to your doctor before taking Circadin as its use is not recommended.
Danish: Der er ikke gennemført undersøgelser af brugen af Circadin hos personer med autoimmun-sygdpmme, derfor skal du tale med din læge, før du tager Circadin, da det ikke kan anbefales at anvende det. - Circadin kan få dig til at føle dig døsig, du skal være forsigtig, his døsigheden påvirker dig, da det kan nedsætte din evne til fx at køre bil.
English: • Melatonin has been observed to induce CYP3A in vitro at supra-therapeutic concentrations.
Danish: • Melatonin inducerer in vitro CYP3A-enzymer ved supraterapeutiske koncentrationer.
English: In an outpatient study with 2 week run-in baseline period with placebo, a randomised, double blind, placebo controlled, parallel group treatment period of 3 weeks and 2 week withdrawal period with placebo, the rate of patients who showed a clinically significant improvement in both quality of sleep and morning alertness was 47% in the Circadin group as compared to 27% in the placebo group.
Danish: I et forsøg med ambulante patienter med to ugers baseline-indkøringsperiode (placebokontrolleret), en randomiseret, dobbeltblind, placebokontrolleret, parallelgruppe behandlingsperiode på tre uger og to ugers nedtrapningsperiode (placebokontrolleret) var andelen af patienter, der viste en klinisk effekt med hensyn til såvel søvnkvalitet som årvågenhed om morgenen 47 % i Circadin-gruppen sammenlignet med 27 % i placebo-gruppen.
English: NAME OF THE MEDICINAL PRODUCT Circadin 2 mg prolonged-release tablets melatonin
Danish: LÆGEMIDLETS NAVN Circadin 2 mg depottabletter melatonin
English: The excretion of the metabolite is completed within 12 hours after ingestion.
Danish: Udskillelse er fuldstændig i løbet af 12 timer efter indtagelse.
English: Leukopenia, thrombocytopenia
Danish: Blod og lymfesystem leukopeni, trombocytopeni
English: NAME OF THE MEDICINAL PRODUCT Circadin 2 mg prolonged-release tablets
Danish: LÆGEMIDLETS NAVN Circadin 2 mg depottabletter
English: How to take Circadin
Danish: Sådan skal du tage Circadin
English: − Benzodiazepines and non-benzodiazepine hypnotics (medicines used to induce sleep such as zaleplon, zolpidem and zopiclone)
Danish: - Benzodiazepiner og hypnotika uden benzodiazepin (indsovningsmedicin som fx zaleplon, zolpidem og zopliclon) - Thioridazin (til behandling af skizofreni) og imipramin (til behandling af depression).
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Danish: Overfølsomhed over for melatonin eller over for et eller flere af hjælpestofferne anført i pkt.
English: Gastro-oesophageal reflux disease, gastrointestinal disorder, oral mucosal blistering, tongue ulceration, gastrointestinal upset, vomiting, bowel sounds abnormal, flatulence, salivary hypersecretion, halitosis, abdominal discomfort, gastric disorder, gastritis
Danish: Mave-tarmkanalen mavesmerter, øvre mavesmerter, dyspepsi, mundsår, mundtørhed, kvalme gastroøsofageal reflukssygdom, mavetarm-sygdom, blister i mundslimhinden, tungeulceration, mavetarm-forstyrrelse, opkastning, abnorme tarmlyde, flatulens, hypersekretion af spyt, halitose, abdominalt ubehag, gastrisk forstyrrelse, gastritis
English: Mood altered, aggression, agitation, crying, stress symptoms, disorientation, early morning awakening, libido increased, depressed mood, depression
Danish: Psykiske forstyrrelser irritabilitet, nervøsitet, rastløshed, søvnløshed, abnorme drømme, mareridt, angst ændret sindsstemning, aggression, agitation, gråd, stresssymptomer, desorientering, tidlig opvågnen, øget libido, nedtrykt sindstilstand, depression
English: Hypertension
Danish: Dosering
English: Therefore, Circadin is not recommended for use in patients with hepatic impairment.
Danish: Circadin bør derfor ikke anvendes til patienter med nedsat leverfunktion.
English: Reproductive system and breast disorders
Danish: Infektioner og parasitære sygdomme herpes zoster
English: - The other ingredients are ammonio methacrylate copolymer type B, calcium hydrogen phosphate dihydrate, lactose monohydrate, silica (colloidal anhydrous), talc and magnesium stearate.
Danish: Calciumhydrogenphosphatdihydrat, lactosemonohydrat, vandfri, kolloid silica, talcum og magnesiumstearat.
English: • Caution should be exercised in patients on fluvoxamine, which increases melatonin levels (by 17-fold higher AUC and a 12-fold higher serum Cmax) by inhibiting its metabolism by hepatic cytochrome P450 (CYP) isozymes CYP1A2 and CYP2C19.
Danish: Det skyldes hæmning af melatonins omsætning via de hepatiske cytokrom P450 (CYP) isozymer: CYP1A2 og CYP2C19.
English: • Visual impairment
Danish: • Nedsat syn
English: See Section 4.
Danish: Se punkt.
English: Syncope, memory impairment, disturbance in attention, dreamy state, restless legs syndrome, poor quality sleep, paraesthesia
Danish: Nervesystemet migræne, hovedpine, letargi, psykomotorisk hyperaktivitet, svimmelhed, somnolens synkope, hukommelsessvækkelse, opmærksomhedsforstyrr else, drømmende sindstilstand, uro i benene (restless legs syndrome), dårlig søvnkvalitet, paræstesier
English: What Circadin is and what it is used for What you need to know before you take Circadin How to take Circadin
Danish: Det skal du vide, før du begynder at tage Circadin Sådan skal du tage Circadin Bivirkninger
English: Ask your doctor or pharmacist for advice before taking this medicine.
Danish: Spørg lægen eller apotekspersonalet, hvis der er noget, du er tvivl om eller føler dig usikker på med hensyn til brugen af denne medicin.
English: The site of biotransformation is the liver.
Danish: Omsætningen sker i leveren.
English: Prolonged-release tablets 20 tablets
Danish: Depottabletter 20 tabletter 21 tabletter 30 tabletter 7 tabletter
English: Dermatitis, night sweats, pruritus, rash, pruritus generalised, dry skin
Danish: Hud og subkutane væv dermatitis, natlige svedeture, pruritus, udslæt, generaliseret pruritus, tør hud eksem, erytem, hånddermatitis, psoriasis, generaliseret udslæt, kløende udslæt, neglelidelser
English: The effect of any stage of renal impairment on melatonin pharmacokinetics has not been studied.
Danish: Melatonins farmakokinetiske egenskaber er ikke undersøgt hos patienter med forskellige grader af nedsat nyrefunktion.
English: Priapism, prostatitis Galactorrhoea
Danish: Det reproduktive system og mammae menopausale symptomer priapisme, prostatitis
English: Hepatobiliary disorders
Danish: Vaskulære sygdomme hypertension hedeture
English: Do not take Circadin if you are pregnant, think you may be pregnant, trying to become pregnant or breast-feeding.
Danish: Hvis du er gravid eller ammer, har mistanke om, at du er gravid eller planlægger at blive gravid, skal du spørge din læge eller apotekspersonalet til råds, før du tager dette lægemiddel.
English: Pain in extremity Arthritis, muscle spasms, neck pain, night cramps
Danish: Knogler, led, muskler og bindevæv smerter i ekstremiteterne arthritis, muskelspasmer, nakkesmerter, nattekramper
English: Angioedema, oedema of mouth, tongue oedema
Danish: Vandfri, kolloid silica Talcum
English: Psychiatric disorders
Danish: LÆGEMIDDELFORM Depottabletter
English: If you take more Circadin than you should
Danish: Hvis du har taget for meget Circadin
English: • Caution should be exercised in patients on oestrogens (e.g. contraceptive or hormone replacement therapy), which increase melatonin levels by inhibiting its metabolism by CYP1A1 and CYP1A2.
Danish: Østrogener øger melatoninniveauerne ved at hæmme den melatoninomsætning, som sker via CYP1A1 og CYP1A2.
English: Eczema, erythema, hand dermatitis, psoriasis, rash generalised, rash pruritic, nail disorder
Danish: Nyrer og urinveje glykosuri, proteinuri polyuri, hæmaturi, nykturi