FrancophonIA/ELRC3.0 huggingface dataset:
English: 1200 mg to 1600 mg (duration varying between 1 to 10 days): Nausea, vomiting, diarrhoea, rash, erythema, oedema, swelling, fatigue, muscle spasms, thrombocytopenia, pancytopenia, abdominal pain, headache, decreased appetite.
Slovenian: Odmerki od 1200 mg do 1600 mg (trajanje zdravljenja od 1 do 10 dni): navzea, bruhanje, driska, izpuščaj, eritem, edemi, otekanje, utrujenost, mišični spazmi, trombocitopenija, pancitopenija, bolečine v trebuhu, glavobol, zmanjšan tek.
English: • Do not breast-feed during the treatment with Imatinib medac as there is limited information on the distribution of imatinib into the breast milk.
Slovenian: • Med zdravljenjem z zdravilom Imatinib medac ne dojite, saj so podatki o prehajanju imatiniba
English: There are no controlled trials in paediatric patients with DFSP.
Slovenian: Pri pediatričnih bolnikih z DFSP niso opravili nobenega kontroliranega preskušanja.
English: 9/l, then resume treatment at 300 mg.
Slovenian: 9/l, nato spet začnite zdravljenje z odmerkom 300 mg.
English: In an oral pre- and postnatal development study in rats, red vaginal discharge was noted in the 45 mg/kg/day group on either day 14 or day 15 of gestation.
Slovenian: V peroralni študiji predporodnega in poporodnega razvoja pri podganah so pri skupini s 45 mg/kg/dan 14. ali 15. dne brejosti opazili rdeč izcedek iz nožnice.
English: There was a significant increase in exposure to imatinib (the mean Cmax and AUC of imatinib rose by 26% and 40%, respectively) in healthy subjects when it was co-administered with a single dose of ketoconazole (a CYP3A4 inhibitor).
Slovenian: Pri zdravih osebah se je izpostavljenost imatinibu značilno povečala (povprečna Cmax in AUC imatiniba sta se povečali za 26 % oziroma 40 %), kadar je bil uporabljen z enim samim odmerkom ketokonazola (zaviralec CYP3A4).
English: Do not use any pack that is damaged or shows signs of tampering.
Slovenian: Ne uporabljajte tega zdravila, če opazite, da je škatla poškodovana ali kaže znake, da je bila že odprta.
English: In the juvenile toxicology study, effects upon growth, delay in vaginal opening and preputial separation were observed at approximately 0.3 to 2 times the average paediatric exposure at the highest recommended dose of 340 mg/m2.
Slovenian: V toksikološki študiji mladih podgan so opazili zakasnitev odprtja nožnice in ločitve prepucija pri povprečni pediatrični izpostavljenosti, ki je bila 0,3 do 2-krat večja od največjega priporočenega odmerka 340 mg/m².
English: 4) Flushing was most common in GIST patients and bleeding (haematoma, haemorrhage) was most common in patients with GIST and with transformed CML (CML-AP and CML-BC).
Slovenian: 4) Navali rdečice so bili najpogostejši pri bolnikih z GIST, krvavitve (hematomi in krvavitve) pa so bile najpogostejše pri bolnikih z GIST ter pri bolnikih s transformacijo KML (KML-AP in KML-BC).
English: In the study in patients with unresectable and/or metastatic GIST, both gastrointestinal and intratumoural haemorrhages were reported (see section 4.8).
Slovenian: V študiji pri bolnikih z neoperabilnim in/ali metastatskim GIST so poročali o krvavitvah iz prebavil in iz tumorja (glejte poglavje 4.8).
English: At the time of the original analysis, three of the four patients with detected PDGFR gene rearrangements developed haematological response (2 CHR and 1 PHR).
Slovenian: V času prvotne analize so trije od štirih bolnikov z dokazano preureditvijo gena za PDGFR dosegli hematološki odziv (2 sta dosegla popolni in 1 delni hematološki odziv).
English: No evidence of leukaemia (NEL) Return to chronic phase (RTC) Major cytogenetic response Complete (Confirmed
Slovenian: Hematološki odziv Popolni hematološki odziv (CHR) Nobenih znakov levkemije (NEL) Vrnitev v kronično fazo (RTC) Pomemben citogenetični odziv Popoln odziv (Potrjen
English: • Numbness of the hands or feet.
Slovenian: • odrevenelost dlani ali stopal,
English: Imatinib medac is indicated for the treatment of
Slovenian: Zdravilo Imatinib medac je indicirano za zdravljenje
English: This Ki value is far higher than the expected plasma levels of imatinib in patients, consequently no interaction is expected upon co-administration of either 5-fluorouracil or paclitaxel and imatinib.
Slovenian: Ta vrednost Ki je mnogo večja kot pričakovane plazemske koncentracije imatiniba pri bolnikih, zato po sočasnem dajanju bodisi 5-fluorouracila ali paklitaksela in imatiniba ni pričakovati medsebojnega delovanja.
English: (2 h, q 12 h), days 2-3 (total of 8 courses)
Slovenian: (2 uri, na 12 ur), 2.-3. dan (skupno 8 kur)
English: The in vitro results showed that CYP3A4 was the major human P450 enzyme catalysing the biotransformation of imatinib.
Slovenian: Rezultati in vitro so pokazali, da je pri človeku poglavitni encim P450, ki katalizira biotransformacijo imatiniba, CYP3A4.
English: 10) Musculoskeletal pain and related events were more commonly observed in patients with CML than in GIST patients.
Slovenian: 10) Mišično-skeletne bolečine in z njimi povezane dogodke so pogosteje opažali pri bolnikih s KML kot pri bolnikih z GIST.
English: Additionally, partial cytogenetic response (PCyR) was observed in 16 % for a MCyR of 81 %.
Slovenian: Poleg tega so zabeležili tudi delen citogenetični odziv (PCyR) pri 16 % bolnikov ob 81 % s pomembnim citogentičnim odzivom.
English: It is important that you do this as long as your doctor, pharmacist or nurse tells you to.
Slovenian: Pomembno je, da zdravilo jemljete tako dolgo, kot vam naroči zdravnik, farmacevt ali medicinska sestra.
English: • Severe headache, weakness or paralysis of limbs or face, difficulty speaking, sudden loss of consciousness (signs of nervous system problems such as bleeding or swelling in skull/brain).
Slovenian: • hud glavobol, oslabelost ali ohromelost okončin ali obraza, težave pri govoru, nenadna izguba zavesti (znaki težav z živčevjem, kot sta krvavitev ali otekanje v lobanjski votlini/možganih),
English: These are blood diseases in which some blood cells (named eosinophils) start growing out of control.
Slovenian: To so bolezni krvi, pri katerih se začnejo nenadzorovano razraščati nekatere krvne celice, ki se imenujejo eozinofilci.
English: In GIST the investigational medicinal product was discontinued for imatinib-related adverse reactions in 4 % of patients.
Slovenian: Pri bolnikih z GIST so prekinitev zdravljenja z raziskovanim zdravilom zaradi neželenih učinkov, povezanih z imatinibom, zabeležili pri 4 % bolnikov.
English: Renal insufficiency: Patients with renal dysfunction or on dialysis should be given the minimum recommended dose of 400 mg daily as starting dose.
Slovenian: Insuficienca ledvic: Bolniki z okvarjenim delovanjem ledvic ali bolniki na dializi naj za začetni odmerek prejmejo najmanjši priporočeni odmerek 400 mg na dan.
English: • adult patients with advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL) with FIP1L1-PDGFRα rearrangement.
Slovenian: • odraslih bolnikov z napredovalim hipereozinofilnim sindromom (HES) ali s kronično eozinofilno levkemijo (CEL) s premestitvijo FIP1L1-PDGFRα ali z obojim,
English: If you get any of the above, tell your doctor straight away.
Slovenian: Če opazite katerega od zgoraj navedenih neželenih učinkov, nemudoma obvestite zdravnika.
English: Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF), PDGF-R, and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular events.
Slovenian: Imatinib je tudi zaviralec receptorskih tirozin-kinaz za rastni faktor iz trombocitov (PDGF-plateletderived growth factor), PDGF-R in dejavnik matičnih celic (SCF-stem cell factor), c-Kit, in zavira celične dogodke, ki jih posredujeta PDGF in SCF.
English: Additionally, improvements in symptomatology and other organ dysfunction abnormalities were reported by the investigators in the case reports.
Slovenian: Poleg navedenega so raziskovalci v opisih primerov poročali tudi o izboljšanju simptomatike in nepravilnosti delovanja drugih organov.
English: Posology for HES/CEL in adult patients
Slovenian: Odmerjanje pri HES/CEL pri odraslih bolnikih
English: Relapsed/refractory Ph+ ALL: When imatinib was used as single agent in patients with relapsed/refractory Ph+ ALL, it resulted, in the 53 out of 411 patients evaluable for response, in a haematological response rate of 30 % (9 % complete) and a major cytogenetic response rate of 23 %.
Slovenian: Relaps/neodzivna Ph+ ALL: Zdravljenje z imatinibom kot edinim zdravilom pri bolnikih z relapsom/neodzivno Ph+ ALL je povzročilo pri 53 od 411 za oceno odziva primernih bolnikov stopnjo hematološkega odziva 30 % (v 9 % popolni hematološki odziv) in stopnjo pomembnega citogenetičnega odziva 23 %.
English: Triple IT therapy (age-adjusted): day 1
Slovenian: zdravljenje (prilagojeno na starost): 1. dan
English: Dosing in paediatric patients at 260 and 340 mg/m2/day achieved the same exposure, respectively, as doses of 400 mg and 600 mg in adult patients.
Slovenian: Odmerek 260 oziroma 340 mg/m² pri pediatričnih bolnikih je dosegel enako izpostavljenost kot odmerek 400 mg oziroma 600 mg pri odraslih bolnikih.
English: Dose increases from 600 mg to a maximum of 800 mg (given as 400 mg twice daily) in patients with blast crisis may be considered in the absence of severe adverse drug reaction and severe non-leukaemia-related neutropenia or thrombocytopenia in the following circumstances: disease progression (at any time); failure to achieve a satisfactory haematological response after at least 3 months of treatment; failure to achieve a cytogenetic response after 12 months of treatment; or loss of a previously achieved haematological and/or cytogenetic response.
Slovenian: Povečanje odmerka s 600 mg na največ 800 mg (ki se daje kot 400 mg dvakrat na dan) pri bolnikih v blastni krizi lahko pride v poštev, če bolnik nima hude neželene reakcije na zdravilo in hude nevtropenije ali trombocitopenije, ki ni povezana z levkemijo, v naslednjih okoliščinah: napredovanje bolezni (kadarkoli); odsotnost zadovoljivega hematološkega odziva po najmanj 3 mesecih zdravljenja; odsotnost citogenetičnega odziva po 12 mesecih zdravljenja; ali izguba že prej doseženega hematološkega in/ali citogenetičnega odziva.
English: Multiple dose toxicity studies revealed mild to moderate haematological changes in rats, dogs and monkeys, accompanied by bone marrow changes in rats and dogs.
Slovenian: Študije toksičnosti ponavljajočih se odmerkov so pokazale blage do zmerne hematološke spremembe pri podganah, psih in opicah.
English: 340 mg/m daily is recommended for paediatric patients with chronic phase CML and accelerated phase CML (not to exceed the total dose of 800 mg).
Slovenian: Za pediatrične bolnike s kronično fazo KML oziroma s pospešeno fazo KML je priporočeni odmerek 340 mg/m² na dan (ne sme preseči celotnega odmerka 800 mg).
English: Newly diagnosed Ph+ ALL: In a controlled study (ADE10) of imatinib versus chemotherapy induction in 55 newly diagnosed patients aged 55 years and over, imatinib used as single agent induced a significantly higher rate of complete haematological response than chemotherapy (96.3 % vs. 50 %; p = 0.0001).
Slovenian: Novo odkrita Ph+ ALL: V kontrolirani študiji (ADE10) imatiniba v primerjavi z indukcijo s kemoterapijo pri 55 bolnikih z novo odkrito boleznijo, ki so bili stari 55 let ali več, je imatinib kot edino zdravilo povzročil značilno večji delež bolnikov s popolnim hematološkim odzivom kot kemoterapija (96,3 % v primerjavi s 50 %; p = 0,0001).
English: Other medicines and Imatinib medac
Slovenian: Druga zdravila in zdravilo Imatinib medac
English: The age of these patients ranged from 25 to 72 years.
Slovenian: Ti bolniki so bili stari od 25 do 72 let.
English: Ara-C 1,000 mg/m2/12 h i.v.
Slovenian: Ara-C 1.000 mg/m²/12 ur i.v.
English: Active substances that may have their plasma concentration altered by imatinib Imatinib increases the mean Cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, indicating an inhibition of the CYP3A4 by imatinib.
Slovenian: Učinkovine, katerih plazemske koncentracije lahko imatinib spremeni Imatinib povečuje povprečno Cmax in AUC simvastatina (substrat CYP3A4) 2-krat oziroma 3,5-krat, kar kaže na to, da imatinib zavira CYP3A4.
English: • Anorexia, weight loss or a disturbed sense of taste.
Slovenian: • izguba apetita, zmanjšanje telesne mase ali moten občutek za okus,
English: Renal toxicity was observed in monkeys treated for 2 weeks, with focal mineralisation and dilation of the renal tubules and tubular nephrosis.
Slovenian: Pri opicah, ki so dobivale zdravilo po 2 tedna, so opazili toksičnost za ledvice z žariščno mineralizacijo in razširitvijo ledvičnih tubulov in tubulno nefrozo.
English: Posology for MDS/MPD in adult patients The recommended dose of imatinib is 400 mg/day for adult patients with MDS/MPD.
Slovenian: Odmerjanje pri MDS/MPD pri odraslih bolnikih Priporočeni odmerek imatiniba pri odraslih bolnikih z MDS/MPD je 400 mg/dan.
English: In the study in patients with unresectable and/or metastatic GIST, grade 3 and 4 anaemia was reported in 5.4 % and 0.7 % of patients, respectively, and may have been related to gastrointestinal or intratumoural bleeding in at least some of these patients.
Slovenian: V študiji so pri bolnikih z neoperabilnim/metastatskim GIST poročali o anemiji 3. oziroma 4. stopnje pri 5,4 % oziroma 0,7 % bolnikov in vsaj pri nekaterih od teh bolnikov je bila anemija povezana s krvavitvijo iz prebavil ali tumorja.
English: There was no change in the kinetics of imatinib on repeated dosing, and accumulation was 1.5-2.5-fold at steady state when dosed once daily.
Slovenian: Pri ponovnem odmerjanju se kinetika imatiniba ni spreminjala, kopičenje pa je bilo pri enem odmerku na dan v stanju dinamičnega ravnovesja 1,5-2,5-kratno.
English: Chronic phase CML, MDS/MPD (starting dose 400 mg)
Slovenian: kronična faza KML, MDS/MPD (začetni odmerek 400 mg) HES/CEL (pri odmerku 400 mg)
English: 6400 mg (single dose): One case reported in the literature of one patient who experienced nausea, vomiting, abdominal pain, pyrexia, facial swelling, decreased neutrophil count, increased transaminases.
Slovenian: Odmerek 6400 mg (enkraten odmerek): v literaturi je opisan en primer pri enem bolniku, pri katerem je prišlo do navzee, bruhanja, bolečin v trebuhu, zvišane telesne temperature, otekanja v obraz, znižane koncentracije nevtrofilcev in zvišanja aminotransferaz.
English: Packs containing 30 hard capsules.
Slovenian: Škatle, ki vsebujejo po 30 trdih kapsul.
English: • Feeling dizzy or weak.
Slovenian: • občutek omotičnosti ali šibkosti,
English: If cytopenia is unrelated to leukaemia, reduce dose of imatinib to 260 mg/m 3.
Slovenian: Če citopenija ni povezana z levkemijo, zmanjšajte odmerek imatiniba na 260 mg/m².
English: Organ function impairment
Slovenian: Moteno delovanje organov
English: If cytopenia is unrelated to leukaemia, reduce dose of imatinib to 400 mg.
Slovenian: Če citopenija ni povezana z levkemijo, zmanjšajte odmerek imatiniba na 400 mg. 3.
English: Some medicines can interfere with the effect of Imatinib medac when taken together.
Slovenian: Nekatera zdravila lahko ob sočasnem jemanju vplivajo na delovanje zdravila Imatinib medac.
English: Maintenance
Slovenian: vzdrževanje
English: • Combination of a widespread severe rash, feeling sick, fever, high level of certain white blood cells or yellow skin or eyes (signs of jaundice) with breathlessness, chest pain/discomfort, severely decreased urine output and feeling thirsty etc. (signs of a treatment-related allergic reaction).
Slovenian: • kombinacija razširjenega hudega izpuščaja, slabosti s siljenjem na bruhanje, povišane telesne temperature, visoke vrednosti nekaterih vrst belih krvnih celic ali rumene obarvanosti kože ali oči (znaka zlatenice) z zasoplostjo, bolečino/neugodjem v prsnem košu, izrazito zmanjšanim izločanjem urina in žejo itd. (znaki alergijske reakcije na zdravljenje),
English: Target organs for neoplastic changes were the kidneys, urinary bladder, urethra, preputial and clitoral gland, small intestine, parathyroid glands, adrenal glands and non-glandular stomach.
Slovenian: Tarčni organi za neoplastične spremembe so bili: ledvice, sečni mehur, sečnica, žleze prepucija in klitorisa, tanko črevo, obščitnične žleze, nadledvične žleze in ne-žlezni del želodca.
English: How much Imatinib medac to take
Slovenian: Koliko zdravila Imatinib medac jemati
English: • Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL).
Slovenian: • s hipereozinofilnim sindromom (HES) ali kronično eozinofilno levkemijo (CEL) ali z obojim.
English: Packs containing 60 hard capsules.
Slovenian: Škatle, ki vsebujejo po 60 trdih kapsul.
English: Patients with severe renal impairment should be treated with caution.
Slovenian: Pri zdravljenju bolnikov s hudo okvarjenim delovanjem ledvic je potrebna previdnost.
English: 9/l, then resume treatment at 200 mg/m
Slovenian: 9/l, nato spet začnite zdravljenje z odmerkom 200 mg/m².
English: Histopathological examination of decedents revealed cardiomyopathy (both sexes), chronic progressive nephropathy (females) and preputial gland papilloma as principal causes of death or reasons for sacrifice.
Slovenian: Histopatološki pregled poginulih je pokazal, da so glavni vzroki smrti oziroma razlogi za žrtvovanje kardiomiopatija (pri obeh spolih), kronična progresivna nefropatija (pri samicah) in papilom žlez prepucija.
English: Posology for CML in paediatric patients Dosing for paediatric patients should be on the basis of body surface area (mg/m2).
Slovenian: Odmerjanje za pediatrične bolnike mora temeljiti na telesni površini (mg/m²).
English: Posology for Ph+ ALL in adult patients
Slovenian: Odmerjanje pri Ph+ ALL pri odraslih bolnikih
English: This inhibition has not been observed in vivo after the administration of imatinib 400 mg and paracetamol 1000 mg. Higher doses of imatinib and paracetamol have not been studied.
Slovenian: Tega zaviranja po uporabi imatiniba 400 mg in paracetamola 1000 mg in vivo niso opažali.
English: Methylprednisolone 40 mg intrathecal, day 1
Slovenian: metilprednizolon 40 mg intratekalno, 1. dan
English: Imatinib medac can help you to fight this condition.
Slovenian: Zdravilo Imatinib medac vam lahko pomaga pri premagovanju te bolezni.
English: The starting dose is 100 mg, to be taken as 1 capsule of 100 mg once a day.
Slovenian: Začetni odmerek je 100 mg, kar vzamete kot 1 kapsulo po 100 mg enkrat na dan.
English: Table 4 Chemotherapy regimen used in combination with imatinib in study I2301
Slovenian: Preglednica 4 Kemoterapevtske sheme, uporabljene v kombinaciji z imatinibom v študiji
English: • adult patients with relapsed or refractory Ph+ ALL as monotherapy.
Slovenian: • odraslih bolnikov z relapsom ali neodzivno Ph+ ALL v monoterapiji,
English: There are no controlled trials demonstrating a clinical benefit or increased survival.
Slovenian: Kontroliranih preskušanj, ki bi dokazovala klinično koristnost ali podaljšanje preživetja, ni.
English: Acute lymphoblastic leukaemia is a form of leukaemia in which certain abnormal white cells (named lymphoblasts) start growing out of control.
Slovenian: Akutna limfoblastna levkemija je oblika levkemije, pri kateri se začnejo nenadzorovano razraščati določene nenormalne bele krvničke, ki se imenujejo limfoblasti.
English: 3) On a patient-year basis, cardiac events including congestive heart failure were more commonly observed in patients with transformed CML than in patients with chronic CML.
Slovenian: 3) Dogodke v zvezi s srcem, vključno s kongestivnim srčnim popuščanjem, so na podlagi enote bolnik-leto pogosteje opažali pri bolnikih s transformacijo KML kot pri bolnikih s kroničnim potekom KML.
English: The dose can be reduced if not tolerated (see sections 4.4, 4.8 and 5.2).
Slovenian: Če bolnik odmerka ne prenaša, ga je mogoče zmanjšati (glejte poglavja 4.4, 4.8 in 5.2).
English: INFORMATION IN BRAILLE Imatinib medac 100 mg
Slovenian: PODATKI V BRAILLOVI PISAVI Imatinib medac 100 mg
English: Close monitoring of growth in paediatric patients under treatment with imatinib is recommended (see section 4.8).
Slovenian: Pri pediatričnih bolnikih, ki prejemajo imatinib, je priporočeno natančno spremljanje njihove rasti (glejte poglavje 4.8).
English: Concomitant use of imatinib and medicinal products that induce CYP3A4 (e.g. dexamethasone, phenytoin, carbamazepine, rifampicin, phenobarbital or Hypericum perforatum, also known as St. John's Wort) may significantly reduce exposure to imatinib, potentially increasing the risk of therapeutic failure.
Slovenian: Sočasna uporaba imatiniba in zdravil, ki inducirajo CYP3A4 (na primer deksametazon, fenitoin, karbamazepin, rifampicin, fenobarbital ali Hypericum perforatum, znan tudi kot šentjanževka), lahko pomembno zmanjša izpostavljenost imatinibu, kar potencialno poveča tveganje za neuspešnost zdravljenja.
English: A slight to moderate reduction in spermatogenesis was also observed in the dog at oral doses ≥ 30 mg/kg.
Slovenian: Pri psu so pri peroralnih odmerkih ≥ 30 mg/kg opazili tudi rahlo do zmerno zmanjšanje spermatogeneze.
English: Imatinib medac is also a treatment for children and adolescents with CML.
Slovenian: Zdravilo Imatinib medac je namenjeno tudi zdravljenju otrok in mladostnikov s KML.
English: The plasma AUC for imatinib decreased by 73 % compared to patients not on EIAEDs.
Slovenian: Pri teh bolnikih se je AUC imatiniba v plazmi zmanjšal za 73 % v primerjavi z bolniki, ki niso jemali antiepileptičnih zdravil, ki inducirajo encime.
English: Rash pustular, contusion, sweating increased, urticaria, ecchymosis, increased tendency to bruise, hypotrichosis, skin hypopigmentation, dermatitis exfoliative, onychoclasis, folliculitis, petechiae, psoriasis, purpura, skin hyperpigmentation,
Slovenian: gnojen izpuščaj, kontuzije, povečano potenje, urtikarija, ekhimoza, nagnjenost k podplutbam, hipotrihoza, hipopigmentacija kože, eksfoliativni dermatitis, lomljenje nohtov, folikulitis, petehije, psoriaza, purpura, hiperpigmentacija kože, bulozne erupcije redki:
English: MTX 15 mg intrathecal, days 1, 8, 15, 22;
Slovenian: MTX 15 mg intratekalno,1., 8., 15., 22. dan;
English: For patients unable to swallow the film-coated tablets, the tablets may be dispersed in a glass of still water or apple juice.
Slovenian: Bolnikom, ki ne morejo pogoltniti kapsul, lahko njihovo vsebino raztopimo v kozarcu navadne vode ali jabolčnega soka.
English: • adult and paediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) integrated with chemotherapy.
Slovenian: • odraslih in pediatričnih bolnikov z na novo diagnosticirano akutno limfoblastno levkemijo, s prisotnim kromosomom Philadelphia (Ph+ ALL) skupaj s kemoterapijo,
English: The paediatric patient received 400 mg/m2/daily, subsequently increased to 520 mg/m2/daily.
Slovenian: Pediatrični bolniki so prejemali 400 mg/m² dnevno, odmerek je bil pozneje zvečan na 520 mg/m² dnevno.
English: No significant age-related pharmacokinetic differences have been observed in patients in clinical trials which included over 20 % of patients aged 65 and older.
Slovenian: Pri odraslih bolnikih v kliničnih preskušanjih, v katerih je bilo več kot 20 % bolnikov, starih 65 let ali več, ni bilo pomembnih farmakokinetičnih razlik, povezanih s starostjo.