FrancophonIA/ELRC3.0 huggingface dataset:
English: The efficacy and safety of Tresiba have been studied in a 1:1 randomised controlled clinical trial in children and adolescents with type 1 diabetes mellitus for a period of 26 weeks (n=350), followed by a 26-week extension period (n=280).
Slovenian: Učinkovitost in varnost zdravila Tresiba so raziskovali v randomiziranem (v razmerju 1:1), nadzorovanem kliničnem preskušanju pri otrocih in mladostnikih s sladkorno boleznijo tipa 1 v obdobju 26 tednov (n = 350), ki mu je sledilo 26-tedensko podaljšanje (n = 280).
English: No metabolic effects are anticipated in the breast-fed newborn/infant.
Slovenian: Presnovnih učinkov na dojene novorojenčke/dojenčke se ne pričakuje.
English: The potency of insulin analogues, including insulin degludec, is expressed in units.
Slovenian: Moč insulinskih analogov, tudi insulina degludek, izražamo v enotah.
English: There is no clinical experience with the use of this medicinal product in children below the age of 1 year.
Slovenian: Kliničnih izkušenj z uporabo tega zdravila pri otrocih, mlajših od 1 leta, ni.
English: Patients who are blind or have poor vision must be instructed to always get help/assistance from another person who has good vision and is trained in using the insulin device.
Slovenian: Bolnikom, ki so slepi ali slabo vidijo, je treba naročiti, da si morajo vedno poiskati pomoč pri osebi, ki dobro vidi in je usposobljena za uporabo injekcijskega peresnika.
English: This was achieved with 30% lower daily doses of Tresiba compared to insulin detemir.
Slovenian: To je bilo doseženo s 30 % manjšimi dnevnimi odmerki zdravila Tresiba v primerjavi z insulinom detemir.
English: A minimum of 8 hours between injections should always be ensured.
Slovenian: Zagotoviti je treba, da med dvema injiciranjima vedno mine vsaj 8 ur.
English: Tap the top of the pen gently a few times to let any air bubbles rise to the top.
Slovenian: Nekajkrat rahlo potrkajte po vrhu injekcijskega peresnika, da se bodo morebitni zračni mehurčki zbrali na vrhu.
English: This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. it is essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na odmerek, kar v bistvu pomeni ‘brez natrija'.
English: In children, care should be taken to match insulin doses (especially in basal-bolus regimens) with food intake and physical activities in order to minimise the risk of hypoglycaemia.
Slovenian: Pri otrocih je treba poskrbeti, da odmerki insulina (še posebej pri bazalno-bolusnih shemah zdravljenja) ustrezajo vnosu hrane in telesni dejavnosti, da se zmanjša tveganje za pojav hipoglikemije.
English: If you notice these skin changes, tell your doctor or nurse.
Slovenian: Če opazite takšne spremembe na koži, obvestite zdravnika ali medicinsko sestro.
English: An updated RMP should be submitted: - At the request of the European Medicines Agency; - Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: • ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: Total exposure after a single dose was, however, higher in children and adolescents than in adults with type 1 diabetes mellitus.
Slovenian: Celotna izpostavljenost po enkratnem odmerku pa je pri otrocih in mladostnikih večja kot pri odraslih s sladkorno boleznijo tipa 1.
English: Patients who forget a dose are advised to take it upon discovery and then resume their usual once-daily dosing schedule.
Slovenian: Bolniki, ki pozabijo odmerek, naj ga vzamejo, ko to ugotovijo, in potem nadaljujejo s predpisanim odmerjanjem enkrat na dan.
English: • If you need more insulin than the units left in your pen, you can split your dose between two pens.
Slovenian: • Če potrebujete več insulina kot je preostalih enot v injekcijskem peresniku, lahko razdelite odmerek in ga injicirate z dvema injekcijskima peresnikoma.
English: • Test your urine or blood for ketones.
Slovenian: • Določite ketone v urinu ali krvi.
English: Method of administration Subcutaneous use only.
Slovenian: Zgolj subkutana uporaba.
English: Inadequate dosing and/or discontinuation of treatment in patients requiring insulin may lead to hyperglycaemia and potentially to diabetic ketoacidosis.
Slovenian: Neustrezno odmerjanje in/ali prekinitev zdravljenja lahko pri bolnikih, ki potrebujejo insulin, povzroči hiperglikemijo in morebiti tudi diabetično ketoacidozo.
English: Pharmacokinetic properties of insulin degludec in children (1-11 years) and adolescents (12-18 years) were at steady state comparable to those observed in adults with type 1 diabetes mellitus.
Slovenian: Farmakokinetične lastnosti insulina degludek pri otrocih (starih od 1 leta do 11 let) in mladostnikih (starih od 12 do 18 let) so v stanju dinamičnega ravnovesja primerljive s tistimi pri odraslih s sladkorno boleznijo tipa 1.
English: Warning signs of too low blood sugar - these may come on suddenly:
Slovenian: Opozorilni znaki previsokega krvnega sladkorja - običajno se pojavijo postopoma
English: If you have a serious allergic reaction (seen rarely) to the insulin or any of the ingredients in Tresiba, stop using this medicine and see a doctor straight away.
Slovenian: Če imate resno alergijsko reakcijo (pojavi se redko) na insulin ali katero koli sestavino zdravila Tresiba, prenehajte z uporabo tega zdravila in nemudoma obiščite zdravnika.
English: At baseline, HbA1c was 8.4% in both treatment groups and after 2 years HbA1c was 7.5% both with Tresiba and insulin glargine.
Slovenian: V izhodišču je bil HbA1c 8,4 % v obeh skupinah in po 2 letih je bil HbA1c tako v skupini, ki je prejemala zdravilo Tresiba, kot v skupini, ki je prejemala insulin glargin, 7,5 %.
English: The educational pack is aimed at increasing awareness about the introduction of a new strength of insulin in the European market and describing key differences in the design of the packages and the pre-filled pen devices to minimise the risk of medication errors and mix up between the two different strengths of Tresiba.
Slovenian: Namen izobraževalnega gradiva je povečati ozaveščenost o uvedbi nove jakosti insulina na evropski trg in opisati ključne razlike v oblikovanju pakiranj in napolnjenih injekcijskih peresnikov, da bi tako čim bolj zmanjšali tveganje za napake z zdravilom in zamenjave obeh različnih jakosti zdravila
English: • Check that the insulin in your pen is clear and colourless.
Slovenian: • Preverite, da je insulin v injekcijskem peresniku bister in brezbarven.
English: After first opening: Do not store above 30°C.
Slovenian: Po prvem odprtju: shranjujte pri temperaturi do 30 °C.
English: Addition of liraglutide resulted in a statistically significantly greater reduction of HbA1c (-0.73% for liraglutide vs -0.40% for comparator, estimated means) and body weight (-3.03 vs 0.72 kg, estimated means).
Slovenian: Dodatek liraglutida je bil povezan s statistično pomembno večjim zmanjšanjem vrednosti HbA1c (-0,73 % pri liraglutidu v primerjavi z -0,40 % pri primerjalnem zdravilu, ocenjeno povprečje) in telesne mase (-3,03 v primerjavi z 0,72 kg, ocenjeno povprečje).
English: As with other basal insulin products, the prolonged effect of Tresiba may delay recovery from hypoglycaemia.
Slovenian: Kot velja za druga bazalna insulinska zdravila, lahko podaljšani učinek zdravila Tresiba upočasni okrevanje po hipoglikemiji.
English: Degradation of insulin degludec is similar to that of human insulin; all metabolites formed are inactive.
Slovenian: Razgradnja insulina degludek je podobna razgradnji človeškega insulina; vsi nastali presnovki so neaktivni.
English: • if the insulin does not appear clear and colourless.
Slovenian: • če insulin ni bister in brezbarven.
English: If you keep injecting in the same place, these reactions can become more severe and affect the amount of medicine your body gets from the pen.
Slovenian: Če zdravilo nenehno injicirate na isto mesto, lahko te reakcije postanejo hujše in vplivajo na količino zdravila, ki jo telo dobi iz injekcijskega peresnika.
English: If a drop of insulin still does not appear, dispose of the pen and use a new one.
Slovenian: Če se kapljica insulina še vedno ne pojavi, zavrzite injekcijski peresnik in uporabite novega.
English: METHOD AND ROUTE OF ADMINISTRATION Needles are not included
Slovenian: POSTOPEK IN POT UPORABE ZDRAVILA Igle niso priložene.
English: Subsequently, dosage should be adjusted individually.
Slovenian: Kasneje je treba odmerek prilagoditi vsakemu bolniku posebej.
English: Important information Pay special attention to these notes as they are important for correct use of the pen.
Slovenian: Upoštevajte te opombe, ker so pomembne za pravilno uporabo injekcijskega peresnika.
English: The primary analysis was time from randomisation to first occurrence of a 3-component major adverse cardiovascular event (MACE) defined as cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke.
Slovenian: Primarna analiza je bil čas od randomizacije do prvega pojava katerega od 3 definiranih pomembnih srčno-žilnih neželenih dogodkov (Major Adverse Cardiovascular Events (MACE)): smrti zaradi srčno žilnih zapletov, miokardnega infarkta brez smrtnega izida ali možganske kapi brez smrtnega izida.
English: Dose button with smooth surface
Slovenian: FlexTouch potisni gumb z gladko površino
English: • The best places to inject are the front of your thighs, upper arms or the front of your waist (abdomen).
Slovenian: • Najprimernejša mesta za injiciranje so sprednji del stegen, nadlahti ali sprednji del pasu (trebuh).
English: • Too high blood sugar (hyperglycaemia)
Slovenian: • Previsok krvni sladkor (hiperglikemija)
English: Tresiba must not be administered intravenously as it may result in severe hypoglycaemia.
Slovenian: Zdravila Tresiba se ne sme aplicirati intravensko, ker lahko povzroči hudo hipoglikemijo.
English: The MAH shall ensure that healthcare professionals are informed that all patients who have been prescribed Tresiba should be provided with a patient brochure and be trained on the correct use of the pre-filled pen before prescribing or dispensing Tresiba.
Slovenian: Imetnik dovoljenja za promet bo poskrbel za seznanitev zdravstvenih delavcev z dejstvom, da je treba vsem bolnikom, ki bodo prejemali zdravilo Tresiba, izročiti brošuro za bolnika ter jih je treba usposobiti za pravilno uporabo napolnjenega injekcijskega peresnika, preden jim je zdravilo Tresiba predpisano ali izdano.
English: If you have kidney or liver problems, you may need to check your blood sugar level more often.
Slovenian: Če imate težave z ledvicami ali jetri, si morate krvni sladkor kontrolirati pogosteje.
English: METHOD OF ADMINISTRATION SC use
Slovenian: za s.c. uporabo
English: • Lead the needle tip into the outer needle cap on a flat surface without touching the needle or the outer needle cap.
Slovenian: • Konico igle vstavite v zunanji pokrovček igle na ravni površini, ne da bi se dotaknili igle ali zunanjega pokrovčka igle.
English: Figure 2 Forest plot of analysis of the composite 3-point MACE and individual cardiovascular endpoints in DEVOTE
Slovenian: Slika 2: Drevesni diagram (“forest plot”) analize MACE s 3 komponentami in posameznih srčno-žilnih opazovanih dogodkov v kliničnem preskušanju DEVOTE
English: If you have symptoms of low blood sugar, take actions to increase your blood sugar level immediately.
Slovenian: Če imate znake prenizkega krvnega sladkorja, takoj ustrezno ukrepajte, da se vam bo koncentracija krvnega sladkorja zvečala.
English: Tresiba must not be used if the solution does not appear clear and colourless.
Slovenian: Zdravila Tresiba se ne sme uporabiti, če raztopina ni bistra in brezbarvna.
English: Other medicines and Tresiba
Slovenian: Druga zdravila in zdravilo Tresiba
English: Only the dose counter and dose pointer will show how many units you select per dose.
Slovenian: Samo števec in kazalnik odmerka kažeta, koliko enot izberete na odmerek.
English: Geriatric patients ≥65 years Type 1 diabetes mellitus Maintenance period b
Slovenian: Geriatrični bolniki ≥ 65 let Sladkorna bolezen tipa 1
English: Patients whose blood glucose control is greatly improved (e.g. by intensified insulin therapy) may experience a change in their usual warning symptoms of hypoglycaemia and must be advised accordingly.
Slovenian: Bolnikom, ki se jim uravnanost glikemije zelo izboljša (npr. z intenziviranim insulinskim zdravljenjem), se običajni opozorilni simptomi hipoglikemije lahko spremenijo in jih je s to možnostjo treba seznaniti.
English: • Tresiba is given as an injection under the skin (subcutaneous injection).
Slovenian: • Zdravilo Tresiba je namenjeno injiciranju pod kožo (subkutani uporabi).
English: • Eat glucose tablets or another high sugar snack, like sweets, biscuits or fruit juice (always carry glucose tablets or a high sugar snack, just in case).
Slovenian: • Zaužijte tablete glukoze ali kakšen drug prigrizek, ki vsebuje veliko sladkorja, na primer bonbone, piškote ali sadni sok (za vsak primer vedno nosite s seboj tablete glukoze ali prigrizek z veliko vsebnostjo sladkorja).
English: • Change the place within the area where you inject each day to reduce the risk of developing lumps and skin pitting (see section 4).
Slovenian: • Mesto injiciranja na posameznem delu telesa, kamor si injicirate zdravilo, menjajte vsak dan, da zmanjšate tveganje za nastanek zatrdlin in ugreznjenosti kože (glejte poglavje 4).
English: Swelling around your joints: When you first start using your medicine, your body may keep more water than it should.
Slovenian: Otekanje sklepov: Ko začnete uporabljati zdravilo, lahko v telesu zastaja več vode, kot je normalno.
English: In direct comparison, requirements for bioequivalence are met for Tresiba 100 units/mL and Tresiba 200 units/mL (based on AUCIDeg,τ,SS and Cmax,IDeg,SS).
Slovenian: V neposredni primerjavi so izpolnjene zahteve za bioekvivalentnost za zdravili Tresiba 100 enot/ml in Tresiba 200 enot/ml (na podlagi AUCIDeg,τ,SS in Cmax, IDeg,SS).
English: The dose steps, however, differ between the two strengths of the medicinal product.
Slovenian: Odmerni koraki pa se med različnima koncentracijama zdravila razlikujejo.
English: In patients with type 2 diabetes mellitus, this medicinal product can be administered alone or in any combination with oral antidiabetic medicinal products, GLP-1 receptor agonists and bolus insulin (see section 5.1).
Slovenian: Pri bolnikih s sladkorno boleznijo tipa 2 je to zdravilo mogoče uporabljati sámo ali v katerih koli kombinacijah s peroralnimi antidiabetiki, z agonisti receptorjev GLP-1 in bolusnim insulinom (glejte poglavje 5.1).
English: Tresiba must not be added to infusion fluids.
Slovenian: Zdravila Tresiba se ne sme dodajati infuzijskim tekočinam.
English: Patients should be instructed to always use a new needle.
Slovenian: Bolnikom je treba naročiti, da morajo vsakič uporabiti novo injekcijsko iglo.
English: On occasions when administration at the same time of the day is not possible, Tresiba allows for flexibility in the timing of insulin administration (see section 5.1).
Slovenian: Prilagodljivost časa odmerjanja V primerih, ko apliciranje ob istem času dneva ni mogoče, zdravilo Tresiba omogoča prilagodljivost v času apliciranja insulina (glejte poglavje 5.1).
English: • Pull off the outer needle cap and keep it for later.
Slovenian: • Snemite zunanji pokrovček igle in ga shranite za pozneje.
English: The duration of action of Tresiba is beyond 42 hours within the therapeutic dose range.
Slovenian: Trajanje delovanja zdravila Tresiba v terapevtskem območju odmerka je več kot 42 ur.
English: When adding GLP-1 receptor agonists to Tresiba, it is recommended to reduce the dose of Tresiba by 20% to minimise the risk of hypoglycaemia.
Slovenian: Pri dodajanju agonista receptorjev GLP-1 k zdravljenju z zdravilom Tresiba je odmerek zdravila Tresiba priporočljivo zmanjšati za 20 %, da se zmanjša tveganje za pojav hipoglikemije.
English: It is used for once-daily dosing.
Slovenian: Uporablja se enkrat dnevno.
English: Local reactions: Local reactions at the place you inject yourself may occur.
Slovenian: Lokalne reakcije: Na mestu injiciranja se lahko pojavijo lokalne reakcije.
English: The cardiovascular safety of Tresiba as compared to insulin glargine was confirmed (HR 0.91 [0.78; 1.06]) (Figure 2).
Slovenian: Varnost zdravila Tresiba glede pojava srčno-žilnih dogodkov v primerjavi z insulinom glargin je bila potrjena (razmerje ogroženosti 0,91 [0,78; 1,06]) (Slika 2).
English: Steady-state serum concentration is reached after 2-3 days of daily Tresiba administration.
Slovenian: Serumska koncentracija v stanju dinamičnega ravnovesja je dosežena v 2 do 3 dneh vsakodnevne uporabe zdravila Tresiba.
English: Figure 1 Glucose infusion rate profile, smoothed, steady state - Mean profile 0-24 hours - IDeg 100 units/mL 0.6 units/kg - Trial 1987
Slovenian: Profil hitrosti infundiranja glukoze, glajen, stanje dinamičnega ravnovesja - povprečni profil 0-24 ur - IDeg 100 enot/ml 0,6 enot/kg - preskušanje 1987
English: Insulin degludec (N26) (CV%)
Slovenian: Insulin degludek (N26) (CV %)
English: If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and oedema.
Slovenian: Pri uporabi te kombinacije je treba pri bolnikih opazovati morebiten pojav znakov in simptomov srčnega popuščanja, pridobivanja telesne mase in prisotnosti edema.
English: • Always carry an extra pen and new needles with you in case of loss or damage.
Slovenian: • Vedno imejte pri sebi rezervni injekcijski peresnik in nove igle, če jih izgubite ali se poškodujejo.
English: Insulin degludec monomers gradually separate from the multi-hexamers thus resulting in a slow and continuous delivery of insulin degludec into the circulation.
Slovenian: Monomeri insulina degludek se postopoma ločujejo od multiheksamerov, tako da se insulin degludek počasi in stalno sprošča v obtok.
English: The following substances may increase the insulin requirement Oral contraceptives, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone and danazol.
Slovenian: Potrebo po insulinu lahko zvečajo naslednje snovi: peroralni kontraceptivi, tiazidi, glukokortikoidi, ščitnični hormoni, simpatikomimetiki, rastni hormon in danazol.
English: In rare cases, the presence of such insulin antibodies may necessitate adjustment of the insulin dose in order to correct a tendency to hyper- or hypoglycaemia.
Slovenian: V redkih primerih je zaradi prisotnosti takšnih protiteles proti insulinu treba prilagoditi odmerek insulina, da bi odpravili nagnjenost k hiperglikemiji ali hipoglikemiji.
English: The total glucose-lowering effect of Tresiba increases linearly with increasing doses.
Slovenian: Celokupni učinek znižanja koncentracije glukoze se pri zdravilu Tresiba linearno povečuje s povečanjem odmerkov.
English: Concomitant illness, especially infections and fever, usually increases the patient's insulin requirement.
Slovenian: Spremljajoče bolezni, posebno okužbe in zvišana telesna temperatura, ponavadi zvečajo bolnikovo potrebo po insulinu.
English: On occasions when you cannot follow your regular dosing schedule, you can change the time of dosing because Tresiba has a long blood sugar-lowering effect (see section 3 for ‘Flexibility in dosing time').
Slovenian: V primerih, ko ne morete upoštevati vašega običajnega časa apliciranja, lahko zdravilo Tresiba uporabite ob drugem času dneva, saj zdravilo Tresiba dolgotrajno znižuje krvni sladkor (glejte poglavje 3, podpoglavje »Prilagodljivo odmerjanje«).
English: %: Percentage of subjects with a first EAC confirmed event relative to the number of randomised subjects.
Slovenian: N: Število oseb s prvim dogodkom med kliničnim preskušanjem, ki ga je potrdil EAC. %: Odstotek oseb s prvim dogodkom, ki ga je potrdil EAC, ki se nanaša na število randomiziranih preiskovancev.
English: The dose counter will show the exact number of units.
Slovenian: Števec odmerka pokaže točno število enot.
English: Approx. how much insulin is left
Slovenian: približno koliko insulina je še ostalo
English: Too low blood sugar may happen if you: drink alcohol; use too much insulin; exercise more than usual; eat too little or miss a meal.
Slovenian: Prenizek krvni sladkor se vam lahko pojavi, če: pijete alkohol, uporabite preveč insulina, ste telesno bolj dejavni kot ponavadi, premalo jeste ali izpustite obrok.
English: • Pioglitazone used together with insulin, see ‘Pioglitazone' below.
Slovenian: • sočasno uporabo pioglitazona in insulina; glejte podpoglavje “Pioglitazon” v nadaljevanju,
English: The trial was designed as a non-inferiority trial to exclude a pre-specified risk margin of 1.3 for the hazard ratio (HR) of MACE comparing Tresiba to insulin glargine.
Slovenian: Preskušanje je bilo načrtovano za ugotavljanje neinferiornosti, da bi izključili predhodno specificirano mejo tveganja 1,3 za razmerje ogroženosti za MACE pri primerjavi zdravila Tresiba z insulinom glargin.
English: • Push the needle straight onto the pen.
Slovenian: • Potisnite iglo naravnost na injekcijski peresnik.
English: Do not place the used needle in household waste.
Slovenian: Uporabljene igle ne zavrzite med gospodinjske odpadke.
English: Before you use Tresiba for the first time, your doctor or nurse will show you how to use it.
Slovenian: Pred prvo uporabo zdravila Tresiba vam bosta zdravnik ali medicinska sestra pokazala, kako se ga uporablja.
English: Immediate-type allergic reactions to either insulin itself or the excipients may potentially be life-threatening.
Slovenian: Takojšnje alergijske reakcije na insulin ali pomožne snovi so potencialno smrtno nevarne.
English: Tresiba was superior compared to insulin glargine in terms of a lower rate of severe hypoglycaemic events and a lower proportion of subjects experiencing severe hypoglycaemia.
Slovenian: Zdravilo Tresiba je bilo superiorno v primerjavi z insulinom glargin zaradi manjšega deleža hudih hipoglikemičnih dogodkov in manjšega deleža bolnikov, pri katerih je prišlo do hude hipoglikemije.
English: Fertility Animal reproduction studies with insulin degludec have not revealed any adverse effects on fertility.
Slovenian: Študije vpliva na sposobnost razmnoževanja na živalih z insulinom degludek ne kažejo neželenih učinkov na plodnost.
English: • Turn the dose selector to select the dose you need, as directed by your doctor or nurse.
Slovenian: • Zavrtite izbirnik odmerka, da boste izbrali odmerek, kot vam je pokazal zdravnik ali medicinska sestra.
English: In type 1 diabetes mellitus, untreated hyperglycaemic events eventually lead to diabetic ketoacidosis, which is potentially lethal.
Slovenian: Pri sladkorni bolezni tipa 1 nezdravljene hiperglikemije vodijo v diabetično ketoacidozo, ki je lahko smrtna.
English: • Do not try to refill your pen.
Slovenian: • Ne poskušajte ga ponovno napolniti.
English: Furthermore, two 64-week controlled, double-blind, randomised, cross-over, treat-to-target trials were conducted in patients with at least one risk factor for hypoglycaemia and with type 1 diabetes mellitus (501 patients) or type 2 diabetes mellitus (721 patients).
Slovenian: Poleg tega sta bili zaključeni dve 64-tedenski, kontrolirani, dvojno slepi, randomizirani, navzkrižni preskušanji z zdravljenjem do cilja pri bolnikih s sladkorno boleznijo tipa 1 (501 bolnik) ali sladkorno boleznijo tipa 2 (721 bolnikov) in z najmanj enim dejavnikom tveganja za hipoglikemijo.
English: See your doctor if they do not disappear after a few weeks.
Slovenian: Če ne minejo po nekaj tednih, pojdite k zdravniku.
English: AUCGIR,2-24h: metabolic effect in last 22 hours of dosing interval (i.e., not influenced by i.v.
Slovenian: AUCGIR,2-24 h: presnovni učinek v zadnjih 22 urah odmernega intervala (tj. brez vpliva intravenskega insulina med uvajalnim obdobjem z vklenjenostjo ["clamp"])