FrancophonIA/ELRC3.0 huggingface dataset:
English: Males showed, however, slightly higher exposure than females.
Croatian: Mužjaci su pokazivali nešto višu ekspoziciju od ženki.
English: Secondary malignancy
Croatian: Sekundarni malignitet
English: Acetylated metabolites are the major biotransformation products of pixantrone.
Croatian: Acetilirani metaboliti su najznačajniji produkti biotransformacije piksantrona.
English: The results of blood tests and your medical condition will also be taken into account.
Croatian: Također će se uzeti u obzir Vaše kliničko stanje i rezultati krvnih pretraga.
English: To avoid the risk of long term infertility, sperm banking should be considered.
Croatian: Da bi se izbjegao rizik dugotrajne neplodnosti treba razmotriti mogućnost pohrane sperme u banku sperme.
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Croatian: Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim slijedećim ažuriranim verzijama objavljenim na europskom internetskom portalu za lijekove.
English: * NYHA: New York Heart Association ** LVEF: Left Ventricular Ejection Fraction
Croatian: * NYHA: New York Heart Association ** LVEF: Left Ventricular Ejection Fraction - ejekcijska frakcija lijevog ventrikula
English: If overdose occurs, supportive management is recommended.
Croatian: Dogodi li se predoziranje preporučuje se primjena potpornog liječenja.
English: Compatibility with other diluents has not been determined.
Croatian: Kompatibilnost s drugim otapalima nije utvrđena.
English: Infections, including pneumonia, cellulitis, bronchitis, and sepsis have been reported during clinical trials (see section 4.8).
Croatian: Infekcije, uključujući pneumoniju, celulitis, bronhitis i sepsu zabilježene su tijekom kliničkih ispitivanja (vidjeti dio 4.8).
English: - if you have very severe liver problems.
Croatian: - ako imate izrazito teško oštećenje jetre.
English: The recommended dose is 50 mg/m2.
Croatian: Preporučena doza iznosi 50 mg/m2.
English: In vitro inhibition studies
Croatian: In vitro ispitivanja inhibicije
English: However, in vitro, conversion of pixantrone into the acetylated metabolites by either NAT1 or NAT2 was very limited.
Croatian: Međutim, in vitro, konverzija piksantrona u acetilirane metabolite pomoću NAT1 ili NAT2 bila je vrlo ograničena.
English: Keep the vial in the outer carton in order to protect from light.
Croatian: Čuvati bočicu u vanjskoj kartonskoj kutiji radi zaštite od svjetlosti.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja i uvjeti čuvanja prije primjene odgovornost su korisnika i ne bi trebali biti dulji od 24 sata na 2°C do 8°C.
English: Pixuvri must not be used with other medicines unless your doctor has told you it is safe to do so.
Croatian: Pixuvri se ne smije koristiti zajedno s drugim lijekovima osim ako Vas liječnik ne uputi da je ta primjena sigurna.
English: No long-term animal studies have been performed to establish the carcinogenic potential of Pixuvri.
Croatian: Nisu provedena ispitivanja dugotrajne primjene na životinjama radi utvrđivanja kancerogenog potencijala lijeka Pixuvri.
English: The safety of intrathecal use has not been established.
Croatian: Sigurnost intratekalne primjene još nije ustanovljena.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 10 May 2012
Croatian: Datum prvog odobrenja: 10. svibnja 2012.
English: This is determined by your height and weight.
Croatian: Vaše visine i težine.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/12/764/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/12/764/001
English: Distribution Pixuvri has a large volume of distribution of 25.8 l and is approximately 50% bound to plasma proteins.
Croatian: Distribucija Pixuvri ima veliki volumen distribucije od 25,8 l a oko 50% se veže za proteine plazme.
English: (See section 4.4)
Croatian: (Vidjeti dio 4.4)
English: The dose modifications should be considered (see section 4.2).
Croatian: Treba razmotriti i potrebu prilagodbe doze (vidjeti dio 4.2).
English: No other significant clinically relevant interactions with CYPP450s were observed.
Croatian: Druge klinički značajne interakcije s enzimima skupine CYP450 nisu primijećene.
English: This applies to women who can become pregnant and men receiving Pixuvri who may be able to father a child.
Croatian: To se odnosi na žene koje mogu zatrudnjeti i na muškarce koji mogu imati djecu, a koji primaju Pixuvri.
English: Dose modification and the timing of subsequent doses should be determined by clinical judgement depending on the degree and duration of myelosuppression.
Croatian: Prilagodbu doze i vrijeme primjene sljedeće doze treba odrediti na temelju kliničke prosudbe, ovisno o stupnju i trajanju mijelosupresije.
English: Minimal cardiotoxicity of Pixuvri was also demonstrated with repeat treatment cycles at the same doses.
Croatian: Minimalna kardiotoksičnost lijeka Pixuvri također je dokazana u ponavljanim ciklusima liječenja s jednakim dozama.
English: It is used for patients whose cancer does not respond or has returned after they have received other chemotherapy treatments.
Croatian: Koristi se kod bolesnika kod kojih tumor ne reagira ili se vratio nakon primjene drugih oblika kemoterapije.
English: In human urine, the compound was mainly excreted unchanged, and very small amounts of phase I and phase II acetylated metabolites were found.
Croatian: Urinom se kod ljudi ovaj spoj uglavnom izlučuje nepromijenjen i u njemu su utvrđene vrlo male količine acetiliranih metabolita faze I i faze II.
English: Your doctor will monitor your heart function if there is any sign or symptom of your heart being affected.
Croatian: Liječnik će pratiti funkciju Vašeg srca radi otkrivanja znakova i simptoma utjecaja liječenja na srce.
English: Pixuvri must not be given to pregnant women as it may cause harm to unborn babies.
Croatian: Pixuvri se ne smije primjenjivati u trudnica jer može izazvati oštećenje nerođenog djeteta.
English: As a precaution, patients should be advised to follow sun protection strategies, including wearing sun protective clothing and using sunscreen.
Croatian: Iz predostrožnosti bolesnike bi trebalo ipak savjetovati da koriste mjere zaštite od sunca, uključujući nošenje zaštitne odjeće i korištenje krema za sunčanje.
English: One vial contains 39 mg sodium.
Croatian: Jedna bočica sadrži 39 mg natrija.
English: Contains sodium, see leaflet for further information.
Croatian: Sadrži natrij, vidjeti uputu o lijeku za dodatne informacije.
English: During treatment with pixantrone, you should minimize or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment).
Croatian: Za vrijeme liječenja piksantronom trebate smanjiti ili izbjegavati izlaganje prirodnim ili umjetnim izvorima sunčevog svjetla (solarij ili liječenje UVA/B lampama).
English: If extravasation occurs the administration should be stopped immediately and restarted in another vein.
Croatian: U slučaju ekstravazacije davanje lijeka treba odmah prekinuti i nastaviti ga u drugoj veni.
English: There is a possibility that your heart pumping function could decrease as a result of the treatment or you might even develop a serious condition called heart failure, especially if your heart function was already compromised at the beginning of the treatment with Pixuvri.
Croatian: Postoji mogućnost da, kao posljedica liječenja, funkcija Vašeg srca kao pumpe bude oslabljena, ili da se razvije ozbiljno stanje koje nazivamo zatajenje srca, naročito ako je funkcija Vašeg srca već bila oslabljena na početku liječenja lijekom Pixuvri.
English: In particular, make sure to tell your doctor if you are currently using, or have recently used, any of the following medicines:
Croatian: Osobito je važno da obavijestite svog liječnika uzimate li trenutno, ili ste nedavno uzimali, bilo koji od sljedećih lijekova:
English: Figure 2 PIX 301 Overall survival-end of study
Croatian: Slika 2 PIX 301 - Ukupno preživljenje - na kraju ispitivanja
English: In vitro studies with the most common human cytochrome P450 isoforms (including CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4) have shown a possible mixed-type inhibition of CYP1A2 and CYP2C8 that may be of clinical relevance.
Croatian: In vitro ispitivanja s najčešćim izoenzimima citokroma P450 u ljudi (uključujući CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, i 3A4), pokazala su moguću inhibiciju miješanog tipa s CYP1A2 i CYP2C8 koja može biti od kliničkog značaja.
English: Tumour response was assessed by a blinded independent central review panel according to the international workshop to standardise response criteria for NHL.
Croatian: Tumorski odgovor ocjenjivala je središnja neovisna grupa stručnjaka (slijepom metodom) prema smjernicama međunarodne radionice za standardizaciju kriterija odgovora NHL.
English: In dogs, tachycardia and electrocardiography (ECG) changes occurred immediately after treatment.
Croatian: U pasa se pojavila tahikardija i promjene u elektrokardiogramu (EKG) odmah nakon primjene lijeka.
English: Other medicines and Pixuvri
Croatian: Drugi lijekovi i Pixuvri
English: READ ENTIRE PREPARATION INSTRUCTIONS PRIOR TO RECONSTITUTION
Croatian: PROČITAJTE ČITAVU UPUTU ZA PRIPREMU LIJEKA PRIJE REKONSTITUCIJE
English: * LLN: Lower Limit of the Normal range ** ANC: Absolute Neutrophil Count
Croatian: * DGN: Donja granica normalnih referentnih vrijednosti ** ABN: Apsolutni broj neutrofila
English: Similar findings were reported in rats, and in dogs at 116 mg/m2.
Croatian: Slični nalazi nađeni su u štakora i pasa pri dozi od 116 mg/m2.
English: What you need to know before you use Pixuvri
Croatian: Što morate znati prije nego primite Pixuvri
English: In repeated-dose studies in mice, rats, and dogs, the main findings were myelotoxicity, nephrotoxicity (except dogs), and testicular damage.
Croatian: U ispitivanjima ponavljane doze na miševima, štakorima i psima, glavni nalaz bila je mijelotoksičnost, nefrotoksičnost (osim u pasa) i oštećenje testisa.
English: OTHER SPECIAL WARNING(S), IF NECESSARY Cytotoxic: Handle with caution.
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A), AKO JE POTREBNO Citotoksično: Rukovati s oprezom.
English: The final concentration of pixantrone in the infusion bag should be less than 580 microgram /ml based upon input of reconstituted medicinal product.
Croatian: Konačna koncentracija piksantrona u vrećici za infuziju trebala bi biti niža od 580 mikrograma/ml, temeljeno na unosu rekonstituiranog lijeka.
English: Pixuvri has been shown to cause phototoxic effects on 3T3 cells in vitro.
Croatian: Pokazalo se da Pixuvri ima fototoksični učinak na 3T3 stanicama in vitro.
English: Pixuvri must be administered by physicians who are familiar with the use of antineoplastic agents and have the facilities for regular monitoring of clinical, haematological, and biochemical parameters during and after treatment (see section 6.6).
Croatian: Pixuvri smiju primjenjivati samo liječnici koji su iskusni u korištenju antineoplastičkih tvari i rade u uvjetima u kojima postoji mogućnost redovitog praćenja kliničkih, hematoloških i biokemijskih parametara za vrijeme i nakon terapije (vidjeti dio 6.6).
English: Whilst the effect on fertility has not been ascertained, a precaution will be to advise male patients to use contraceptive methods (preferably barrier) during treatment and for a period of 6 months post-treatment to allow new sperm to mature.
Croatian: Iako ovaj učinak na plodnost još nije provjeren, radi opreza se muškim bolesnicima savjetuje koristiti metode kontracepcije (po mogućnosti u obliku barijere) za vrijeme liječenja i u razdoblju od 6 mjeseci nakon liječenja, kako bi se omogućilo sazrijevanje novih spermatozoida.
English: Patients with serum creatinine > 2 x Upper Limit of the Normal range (ULN) were excluded from the randomised studies.
Croatian: Bolesnici s razinom serumskog kreatinina > 2 x gornje granice referentnih vrijednosti isključeni su iz randomiziranih ispitivanja.
English: Pixuvri has a deep blue colour and for several days after receiving Pixuvri, your skin and eyes may develop a bluish discolouration, and your urine may have a bluish discolouration.
Croatian: Pixuvri je tamno plave boje i nekoliko dana nakon njegove primjene Vaša koža i oči mogu poprimiti plavičastu boju, a isto tako i mokraća može postati plavičasta.
English: Effects on hepatic or renal function were minimal.
Croatian: Učinak na jetrenu i bubrežnu funkciju bio je minimalan.
English: The incidence of severe infections was low and opportunistic infections associated with immunocompromise were not seen.
Croatian: Incidencija teških infekcija bila je niska, a oportunističke infekcije povezane s kompromitiranim imunološkim odgovorom nisu zabilježene.
English: Table 4 Summary of response per independent assessment panel (ITT population) End-of-Treatment
Croatian: Sažetak odgovora na terapiju prema procjeni nezavisne skupine stručnjaka (populacija ITT) Na kraju liječenja
English: Pixuvri does not contain anything to prevent the growth of bacteria and it is therefore recommended that it be used immediately after reconstitution.
Croatian: Pixuvri ne sadrži sredstva za sprječavanje rasta bakterija i stoga se preporučuje primijeniti ga odmah nakon pripreme.
English: Neoplasm progression
Croatian: Progresija neoplazme
English: Very common Skin discolouration, alopecia
Croatian: Vrlo često Promjena boje kože, alopecija
English: In dogs, Pixuvri given at 0.5 to 0.9 mg/kg for six cycles did not cause mortality or severe clinical signs, including ECG or body weight changes.
Croatian: U pasa, Pixuvri primjenjivan u dozi od 0,5 do 0,9 mg/kg kroz 6 ciklusa nije bio uzrok mortalitetu ili teškim kliničkim simptomima, uključujući promjene u EKG-u i tjelesnoj težini.
English: Pixantrone dimaleate up to 27 mg/kg given twice a week for 4 weeks did not induce any cardiotoxic effects, while mitoxantrone, as expected, was cardiotoxic at all tested doses (0.6, 1.6, and 1.5 mg/kg).
Croatian: Piksantrondimaleat, u dozi do 27 mg/kg dva puta tjedno kroz 4 tjedna nije inducirao kardiotoksične učinke, dok je mitoksantron, prema očekivanju, bio kardiotoksičan u svim ispitivanim dozama (0,6, 1,6 i 1,5 mg/kg).
English: There are no data from the use of pixantrone in pregnant women.
Croatian: Nema podataka o primjeni piksantrona u trudnica.
English: Immunisation with live virus vaccines is contraindicated due to the immunosuppression associated with Pixuvri therapy (see section 4.3).
Croatian: Imunizacija cjepivima sa živim virusima je kontraindicirana zbog imunosupresije povezane s primjenom lijeka Pixuvri (vidjeti dio 4.3).
English: The BSA should be determined using the institutional standard for BSA calculation and should use a weight measured on day 1 of every cycle.
Croatian: Za određivanje BSA koriste se standardne tablice za izračun BSA pri čemu u izračunu treba koristiti tjelesnu težinu bolesnika izmjerenu prvog dana svakog ciklusa.
English: The amounts (dose) of Pixuvri that will be given to you will depend on your body surface area in square meters (m2).
Croatian: Količina (doza) lijeka Pixuvri koju ćete primiti ovisit će o površini Vašeg tijela izraženoj u kvadratnim metrima (m2).
English: As metabolism appears to be limited, biliary excretion of unchanged pixantrone may be the major elimination pathway.
Croatian: Budući da izgleda da mu je metabolizam ograničen, izlučivanje putem žuči nepromijenjenog piksantrona može predstavljati glavni put eliminacije.
English: Pixuvri is given on days 1, 8, and 15 of each 28-day cycle for up to 6 cycles.
Croatian: Pixuvri se daje 1., 8. i 15. dana svakog 28-dnevnog ciklusa, do ukupno 6 ciklusa.
English: Patients with neutropenia are more susceptible to infections, although, in the clinical studies there was no increased incidence of atypical, difficult-to-treat infections, such as systemic mycotic infections or infections with opportunistic organisms such as Pneumocystis jiroveci.
Croatian: Bolesnici s neutropenijom osjetljiviji su na infekcije, iako u kliničkim ispitivanjima nije bilo porasta incidencije atipičnih infekcija teških za liječenje, kao što su sistemske gljivične infekcije ili oportunističke infekcije mikroorganizmima poput Pneumocystis jirovecii.
English: Cardiac toxicity with Pixuvri may occur whether or not cardiac risk factors are present.
Croatian: Kardiotoksičnost lijeka Pixuvri može nastupiti bez obzira postoje li faktori kardiološkog rizika ili ne.
English: Dark blue lyophilised powder.
Croatian: Liofilizirani prašak tamnoplave boje.
English: Patients treated with Pixuvri showed a significantly higher rate of complete responses and unconfirmed complete responses (CR/CRu), and a higher objective response rate (ORR), compared to the comparator group (see Table 4).
Croatian: Bolesnici liječeni lijekom Pixuvri pokazali su značajno višu stopu potpunog odgovora i nepotvrđenog potpunog odgovora na terapiju (CR/CRu) i višu objektivnu stopu odgovora na terapiju (ORR - engl. objective response rate), u usporedbi s kontrolnom skupinom (vidjeti Tablicu 4).
English: Cardiac toxicity
Croatian: Kardijalna toksičnost
English: Patients on a sodium restricted diet
Croatian: Bolesnici na dijeti s ograničenjem unosa soli
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C, unless reconstitution and dilution have taken place in controlled and validated aseptic conditions.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja i uvjeti čuvanja prije primjene odgovornost su korisnika i ne bi trebali biti dulji od 24 sata na temperaturi od 2°C do 8°C, osim ako su se rekonstitucija i razrjeđivanje proveli u kontroliranim i validiranim aseptičkim uvjetima.
English: The powder should completely dissolve in 60 seconds with agitation.
Croatian: Prašak bi se trebao potpuno otopiti za 60 sekundi uz mućkanje.
English: Pixuvri was mutagenic in the Ames test, increased the number of chromosomal aberrations in human lymphocytes, and increased the frequency of micronuclei in vivo.
Croatian: Pixuvri je bio mutagen u Amesovom testu, povećavajući broj kromosomskih aberacija u humanim limfocitima i uzrokovao porast učestalosti mikronukleusa in vivo.
English: Pixuvri Dose (mg/m2) Number of patients
Croatian: Pixuvri doza (mg/m2)
English: Pixuvri belongs to a pharmacotherapeutic group of medicines known as ‘antineoplastic agents'.
Croatian: Pixuvri pripada farmakoterapijskoj skupini lijekova poznatoj i pod nazivom “antineoplastički lijekovi”.
English: Hematologic toxicities and complications of neutropenia Hematologic toxicities have been the most frequent toxicity observed but they have, in general, been easily managed with granulocyte-colony stimulating factor (G-CSF) and transfusion support as needed.
Croatian: Hematološka toksičnost i komplikacije neutropenije Hematološka toksičnost je najčešća primijećena toksičnost, ali općenito govoreći, može se lako kontrolirati primjenom čimbenika stimulacije rasta kolonije granulocita (G-CSF) i transfuzijom prema potrebi.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national system listed in Appendix V.
Croatian: Od zdravstvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava: navedenog u Dodatku V.
English: Due to this unique structure, pixantrone produced minimal cardiotoxicity in animal models compared with doxorubicin or mitoxantrone.
Croatian: Zbog svoje jedinstvene strukture piksantron je minimalno kardiotoksičan u životinjskim modelima u usporedbi s doksorubicinom ili mitoksantronom.
English: Do not use Pixuvri: - if you are allergic to pixantrone dimaleate or any of the other ingredients of this medicine
Croatian: Nemojte primiti Pixuvri: - ako ste alergični na piksantrondimaleat ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: Pixuvri may be metabolised in the liver and/or excreted in the bile.
Croatian: Pixuvri se može metabolizirati u jetri i/ili izlučiti u žuč.
English: Before the infusion is administered you may be given medicines to prevent or reduce possible reactions to Pixuvri, such as medicines to prevent sickness.
Croatian: Vam se dati lijekovi za sprječavanje ili smanjenje mogućih reakcija na Pixuvri, poput lijekova protiv mučnine.
English: No local tolerance study was conducted.
Croatian: Nisu provedena ispitivanja podnošljivosti lokalne primjene.
English: Experience with pixantrone is limited to patients with LVEF ≥ 45% with most patients having values ≥ 50%.
Croatian: Iskustva s piksantronom u bolesnika čija je vrijednost LVEF ≥ 45% su ograničena; većina je bolesnika imala vrijednosti ≥ 50%.
English: Furthermore, because it incorporates a nitrogen heteroatom into the ring structure and does not have ketone groups, pixantrone has less potential for generating reactive oxygen species, binding iron, and forming alcohol metabolites that are felt to cause the cardiac toxicity of anthracyclines.
Croatian: Budući da u svojoj prstenastoj strukturi sadrži heteroatom dušika, a ne sadrži ketonske skupine, ima manji potencijal stvaranja reaktivnih spojeva kisika, vezivanja željeza i tvorbe alkoholnih metabolita za koje se smatra da su uzrok kardiotoksičnosti antraciklina.
English: Embryotoxicity was characterised by reduced mean foetal weight, foetal malformations and incomplete or delayed foetal ossification.
Croatian: Embriotoksičnost je bila karakterizirana smanjenom srednjom fetalnom težinom, fetalnim malformacijama i nepotpunom ili zakašnjelom osifikacijom u fetusa.
English: Other common toxicities
Croatian: Ostale česte toksičnosti
English: Therefore, metabolism does not appear to be an important elimination pathway for pixantrone.
Croatian: Stoga izgleda da metabolizacija nije bitan put eliminacije piksantrona.
English: In addition, caution should be taken when pixantrone is continuously co-administered with efflux transport inducers such as rifampicin, carbamazepin and glucocorticoids, as pixantrone excretion might be increased with a consequent decrease of systemic exposure.
Croatian: Nadalje, oprez je potreban i kad se piksantron kontinuirano primjenjuje zajedno s induktorima efluksnih transportera, kao što su rifampicin, karbamazepin i glukokortikoidi, budući da izlučivanje piksantrona može biti povećano s posljedičnim smanjenjem sistemske ekspozicije.
English: If you will be exposed to sunlight, you should wear sunprotective clothing and use sunscreen that strongly absorbs UV-A.
Croatian: Ako se namjeravate izložiti sunčevom svjetlu trebate nositi odjeću koja štiti od sunca i koristiti zaštitni faktor koji jako apsorbira
English: Most patients had received prior doxorubicin or equivalent at dose of up to 450 mg/m².
Croatian: Većina bolesnika su primili doksorubicin ili ekvivalent u dozi do 450 mg/m2.
English: Unlike approved anthracyclines (doxorubicin and others) and anthracenediones (mitoxantrone), pixantrone is only a weak inhibitor of topoisomerase II.
Croatian: Za razliku od odobrenih antraciklina (doksorubicin i ostali) i antracendiona (mitoksantron), piksantron je samo slab inhibitor topoizomeraze II.
English: Event (death) Median OS (95% CI)
Croatian: Medijan ukupnog preživljenja (95% CI)
English: From an analysis of population PK data, for a target recorded dose of 50 mg/m2 of pixantrone the median 28-day cycle exposure was 6320 ng.hr/ml (90% CI, 5990-6800 ng.hr/ml), for 3 doses / 4 week cycle.
Croatian: Prema analizi populacijskih farmakokinetičkih podataka za ciljnu zabilježenu dozu od 50 mg/m2 piksantrona, medijan ekspozicije tijekom 28-dnevnog ciklusa bio je 6320 ng.hr/ml (90% CI, 5990-6800 ng.hr/ml), za ciklus od 3 doze / 4 tjedna.