FrancophonIA/ELRC3.0 huggingface dataset:
English: The pharmacokinetic properties of etravirine have been evaluated in adult healthy subjects and in adult and paediatric treatment-experienced HIV-1 infected patients.
Croatian: Farmakokinetička svojstva etravirina procijenjena su u odraslih zdravih ispitanika te u odraslih i pedijatrijskih bolesnika zaraženih virusom HIV-1 koji su prethodno bili liječeni.
English: Table 7: Population pharmacokinetic estimates of etravirine 200 mg twice daily in HIV-1 infected adult subjects (integrated data from Phase III trials at week 48)*
Croatian: Tablica 7: Populacijska farmakokinetička procjena za etravirin 200 mg dva puta dnevno u odraslih ispitanika zaraženih HIVom-1 (integrirani podaci iz ispitivanja faze III u 48. tjednu)*
English: Co-infection with HBV (hepatitis B virus) or HCV (hepatitis C virus) Caution should be exercised in patients co-infected with hepatitis B or C virus due to the current limited data available.
Croatian: Istodobna infekcija virusom hepatitisa B (HBV) ili hepatitisa C (HCV) Potreban je oprez kod bolesnika koji istodobno imaju infekciju virusom hepatitisa B ili C, s obzirom na to da su trenutno raspoloživi podaci ograničeni.
English: Swallow the INTELENCE tablet(s) whole with a glass of water.
Croatian: Tabletu(e) lijeka INTELENCE progutajte cijele s čašom vode.
English: Virologic parameters
Croatian: Virološki parametri
English: The rash is usually mild to moderate.
Croatian: Osip je obično blagog do umjerenog intenziteta.
English: No human data on the effect of etravirine on fertility are available.
Croatian: Ne postoje podaci o učinku etravirina na plodnost u čovjeka.
English: 0.035 mg once daily
Croatian: 0,035 mg jedanput dnevno.
English: - Virologic response was defined as achieving a confirmed undetectable viral load (< 50 HIV-1 RNA copies/ml).
Croatian: - Virološki odgovor je definiran kao postizanje potvrđenog nemjerljivog virusnog opterećenja (< 50 HIV-1 RNK kopija/ml).
English: Dose adjustments for these HMG Co-A reductase inhibitors may be necessary.
Croatian: Za ove inhibitore HMG Co-A reduktaze može biti potrebna prilagodba doze.
English: ANTIARRHYTHMICS Digoxin
Croatian: ANTIARITMICI Digoksin
English: The breakpoints for reduced efficacy with etravirine (> 2 etravirine-associated mutations at baseline, see clinical results section) applies when etravirine is given in combination with a boosted protease inhibitor.
Croatian: Točka promjene u kojoj se smanjuje djelotvornost etravirina (> 2 mutacije povezane s etravirinom na početku liječenja, vidjeti dio s kliničkim rezultatima) primjenjiva je kada se etravirin daje u kombinaciji s pojačanim inhibitorima proteaze.
English: The incidence of rash was higher in women compared to men in the etravirine arm in the DUET trials (rash ≥ grade 2 was reported in 9/60 [15.0%] women versus 51/539 [9.5%] men; discontinuations due to rash were reported in 3/60 [5.0%] women versus 10/539 [1.9%] men) (see section 4.4).
Croatian: U ispitivanjima DUET incidencija osipa bila je veća kod žena nego kod muškaraca u skupini koja je primala etravirin (osip ≥ stupanj 2 bio je prijavljen u 9/60 [15,0%] žena naspram 51/539 [9,5%] muškaraca; prekidi zbog osipa bili su prijavljeni u 3/60 [5,0%] žena naspram 10/539 [1,9%] muškaraca) (vidjeti dio 4.4).
English: ANTIFUNGALS Fluconazole 200 mg once in the morning fluconazole
Croatian: 200 mg jedanput ujutro flukonazol
English: In vitro and in vivo studies with etravirine revealed no evidence of a mutagenic potential.
Croatian: Ispitivanja etravirina in vitro i in vivo nisu pokazala mutageni potencijal.
English: The recommended dose of INTELENCE is 200 mg twice a day.
Croatian: Preporučena doza lijeka INTELENCE je 200 mg dva puta dnevno.
English: Etravirine is a weak inducer of CYP3A4.
Croatian: Etravirin slabo inducira djelovanje CYP3A4.
English: Unchanged etravirine in faeces is likely to be unabsorbed drug.
Croatian: Nepromijenjeni etravirin u stolici vjerojatno je neapsorbirani lijek.
English: If you are taking any of these, ask your doctor for advice.
Croatian: Ukoliko uzimate bilo koji od tih lijekova, obratite se svom liječniku za savjet.
English: The pharmacokinetics of etravirine have not been studied in patients with severe hepatic impairment (Child-Pugh Class C).
Croatian: Farmakokinetika etravirina nije ispitivana kod bolesnika s teškim oštećenjem jetre (Child-Pugh stadij C).
English: As a general rule, it is recommended that mothers infected by HIV do not breastfeed their babies under any circumstances in order to avoid transmission of HIV.
Croatian: Kao opće pravilo, majkama inficiranim HIV-om, preporučuje se da ne doje ni pod kojim uvjetima radi izbjegavanja prijenosa HIVa.
English: In rats, there was no effect on mating or fertility with etravirine treatment (see section 5.3).
Croatian: U štakora liječenje etravirinom nije imalo učinka na parenje ili plodnost (vidjeti dio 5.3).
English: Study TMC114HIV3015 evaluated etravirine 200 mg twice daily in combination with other antiretroviral medicinal products in 15 pregnant women during the second and third trimesters of pregnancy and postpartum.
Croatian: Ispitivanje TMC114HIV3015 procijenilo je etravirin u dozi od 200 mg dva puta dnevno u kombinaciji s drugim antiretrovirusnim lijekovima kod 15 trudnica tijekom drugog i trećeg tromjesečja trudnoće i u postpartalnom razdoblju.
English: 4.8 log10 copies/ml
Croatian: 4,8 log10kopija/ml 4,8 log10kopija/ml
English: Adverse reactions reported in patients treated with etravirine are summarised in Table 2.
Croatian: Nuspojave koje su prijavljene kod bolesnika liječenih etravirinom sažete su u tablici 2.
English: Rash was reported more frequently in female subjects than in male subjects (rash ≥ grade 2 was reported in 13/64 [20.3%] females versus 2/37 [5.4%] males; discontinuations due to rash were reported in 4/64 [6.3%] females versus 0/37 [0%] males) (see section 4.4).
Croatian: Osip je češće prijavljen u ženskih ispitanika nego u muških ispitanika (osip ≥ stupnja 2 bio je prijavljen u 13/64 [20,3%] žena naspram 2/37 [5,4%] muškaraca; prekidi zbog osipa bili su prijavljeni u 4/64 [6,3%] žena naspram 0/37 [0%] muškaraca)
English: Etravirine is primarily metabolised and eliminated by the liver and highly bound to plasma proteins.
Croatian: Etravirin se metabolizira i eliminira prvenstveno putem jetre te se u velikoj mjeri veže na proteine plazme.
English: Age at screening Treatment group
Croatian: Dob prilikom probira Skupina liječenja
English: No dose adjustment is suggested in patients with mild or moderate hepatic impairment (Child-Pugh Class A or B); INTELENCE should be used with caution in patients with moderate hepatic impairment.
Croatian: Nije potrebna prilagodba doze kod bolesnika s blagim ili umjerenim oštećenjem jetre (Child-Pugh stadij A ili B), međutim, INTELENCE treba primjenjivati s oprezom u bolesnika s umjerenim oštećenjem jetre.
English: Exposure in mice was equivalent to human exposure while in rats it was below the clinical exposure at the recommended dose.
Croatian: Izloženost u miševa bila je jednaka izloženosti u čovjeka, dok je u štakora bila manja od kliničke izloženosti pri preporučenoj dozi.
English: Raltegravir 400 mg twice daily raltegravir
Croatian: Raltegravir 400 mg dva puta dnevno raltegravir
English: There are no data with regard to symptomatic overdose with etravirine, but it is possible that the most frequent adverse reactions of etravirine, i.e. rash, diarrhoea, nausea, and headache would be the most common symptoms noted.
Croatian: Nema podataka vezanih uz simptomatsko predoziranje s etravirinom, ali moguće je da će najčešći zabilježeni simptomi biti najčešće nuspojave etravirina, npr. osip, proljev, mučnina i glavobolja.
English: If you have stopped treatment due to a hypersensitivity reaction, you should not restart therapy with INTELENCE.
Croatian: Ako ste prekinuli liječenje zbog reakcije preosjetljivosti, ne smijete ponovo početi uzimati INTELENCE.
English: Disopyramide Flecainide Lidocaine (systemic) Mexiletine Propafenone Quinidine
Croatian: Lidokain (sistemski) Meksiletin Propafenon Kinidin
English: 300/100 mg once daily atazanavir
Croatian: 300/100 mg jedanput dnevno atazanavir
English: Since etravirine is highly protein bound, dialysis is unlikely to result in significant removal of the active substance.
Croatian: S obzirom da se etravirin u velikoj mjeri veže na proteine, nije vjerojatno da bi dijaliza značajno uklonila djelatnu tvar.
English: ANTICONVULSANTS Carbamazepine Phenobarbital Phenytoin
Croatian: Karbamazepin Fenobarbital Fenitoin
English: In healthy subjects, the absorption of etravirine is not affected by co-administration of oral ranitidine or omeprazole, medicinal products that are known to increase gastric pH.
Croatian: U zdravih ispitanika na apsorpciju etravirina ne utječe istodobna peroralna primjena ranitidina ili omeprazola, lijekova za koje se zna da povećavaju pH u želucu.
English: 50 mg once daily
Croatian: 50 mg jedanput dnevno
English: Median CD4 cell count
Croatian: Medijan broja CD4 stanica
English: In a study comparing 8 patients with mild (Child-Pugh Class A) hepatic impairment to 8 matched controls and 8 patients with moderate (Child-Pugh Class B) hepatic impairment to 8 matched controls, the multiple dose pharmacokinetic disposition of etravirine was not altered in patients with mild to moderate hepatic impairment.
Croatian: U ispitivanju koje uspoređuje 8 bolesnika s blagim (Child-Pugh stadij A) oštećenjem jetre s 8 odgovarajućih kontrolnih ispitanika i 8 bolesnika s umjerenim (Child-Pugh stadij B) oštećenjem jetre s 8 odgovarajućih kontrolnih ispitanika, farmakokinetička raspoloživost etravirina kod višestruke doze nije izmijenjena kod bolesnika s blagim do umjerenim oštećenjem jetre.
English: Cardiac disorders common myocardial infarction uncommon atrial fibrillation, angina pectoris
Croatian: Srčani poremećaji često infarkt miokarda manje često fibrilacija atrija, angina pektoris
English: Therefore, the pharmacokinetic parameter estimates shown in the table account for reductions in the pharmacokinetic parameters of etravirine due to co-administration of etravirine with darunavir/ritonavir.
Croatian: Stoga, procjene farmakokinetičkih parametara koje su prikazane u tablici uzimaju u obzir smanjenje farmakokinetičkih prametara etravirina radi istodobne primjene etravirina s darunavirom/ritonavirom.
English: Pivotal studies
Croatian: Pivotalna ispitivanja
English: Patients should be informed to seek medical advice if severe rash or hypersensitivity reactions occur.
Croatian: Bolesnike treba uputiti da potraže liječnički savjet u slučaju pojave teškog osipa ili reakcija preosjetljivosti.
English: There are insufficient data at this time to recommend a dose in paediatric patients less than 6 years of age or weighing less than 16 kg (see section 4.2).
Croatian: Trenutno ne postoji dovoljno podataka za preporuku doze u pedijatrijskih bolesnika dobi manje od 6 godina i težine manje od 16 kg (vidjeti dio 4.2).
English: The DRESS syndrome is characterised by rash, fever, eosinophilia and systemic involvement (including, but not limited to, severe rash or rash accompanied by fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis and eosinophilia).
Croatian: DRESS sindrom karakteriziran je osipom, vrućicom, eozinofilijom i sistemskom reakcijom (uključuje, ali se ne ograničava na težak osip ili osip praćen vrućicom, opće slabo stanje, umor, bolove u mišićima ili zglobovima, mjehuriće, oralne lezije, konjunktivitis, hepatitis i eozinofiliju).
English: There was no gender difference in severity or treatment discontinuation due to rash.
Croatian: Razlika u spolu nije bilo kod procjene težine ili prestanka liječenja zbog osipa.
English: In the rat, the key target organs identified were the liver, the thyroid and the coagulation system.
Croatian: U štakora su ključni ciljni organi bili jetra, štitnjača i koagulacijski sustav.
English: At week 12, virologic response was greater in the control-PI arm (-2.2 log10 copies/ml from baseline; n = 53) compared to the etravirine arm (-1.4 log10 copies/ml from baseline; n = 40).
Croatian: U 12. tjednu virološki odgovor bio je veći u kontrolnoj skupini koja je primala IP (-2,2 log10 kopija/ml od početne vrijednosti; n = 53) nego u skupini koja je primala etravirin (-1,4 log10 kopija/ml u odnosu na početnu vrijednost; n = 40).
English: Table 4: DUET-1 and DUET-2 pooled data
Croatian: Tablica 4: Objedinjeni podaci za DUET-1 i DUET-2
English: The total etravirine exposure after intake of etravirine 200 mg twice daily as part of an antiretroviral regimen was generally higher during pregnancy compared with postpartum (see Table 9).
Croatian: Izloženost ukupnom etravirinu, nakon primjene etravirina 200 mg dva puta dnevno kao dijela antiretrovirusnog režima liječenja, bila je općenito veća tijekom trudnoće u usporedbi s postpartalnim razdobljem (vidjeti Tablicu 9).
English: Etravirine retains activity against HIV-1 viral strains resistant to nucleoside reverse transcriptase and/or protease inhibitors.
Croatian: HIV-1 otpornih na nukleozidne inhibitore reverzne transkriptaze i/ili inhibitore proteaze.
English: Using the oral solution may be considered for dose reduction.
Croatian: Može se razmotriti korištenje oralne otopine za smanjenje doze.
English: The most frequent side effects of INTELENCE are rash, diarrhoea, nausea, and headache (see section ‘4.
Croatian: Najčešće nuspojave lijeka INTELENCE su osip, proljev, mučnina i glavobolja (pogledajte dio „4. Moguće nuspojave“).
English: Store in the original bottle and keep the bottle tightly closed in order to protect from moisture.
Croatian: Čuvati u originalnoj boci i bocu držite čvrsto zatvorenu radi zaštite od vlage.
English: INTELENCE, in combination with a boosted protease inhibitor and other antiretroviral medicinal products, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients and in antiretroviral treatment-experienced paediatric patients from 6 years of age (see sections 4.4, 4.5 and 5.1).
Croatian: INTELENCE je indiciran u kombinaciji s pojačanim inhibitorom proteaze i drugim antiretrovirusnim lijekovima za liječenje infekcije virusom humane imunodeficijencije (HIV-1) u odraslih bolesnika koji su prethodno liječeni antiretrovirusnim lijekovima i u pedijatrijskih bolesnika koji su prethodno liječeni antiretrovirusnim lijekovima u dobi od 6 godina i više (vidjeti dijelove 4.4, 4.5 i 5.1).
English: Caution should be observed in such patients, especially in case of history of a severe cutaneous drug reaction.
Croatian: Kod takvih je bolesnika potreban oprez, osobito u slučaju teških kožnih reakcija na lijekove u anamnezi.
English: The clinical data are limited and an increased risk of cutaneous reactions in patients with a history of NNRTI-associated cutaneous reaction cannot be excluded (see section 4.4).
Croatian: Klinički podaci su ograničeni, te se povećani rizik kožnih reakcija kod bolesnika koji su prethodno imali slučajeve kožnih reakcija vezane uz NNRTI ne može isključiti (vidjeti dio 4.4).
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Croatian: Pojava autoimunih poremećaja (poput Gravesove bolesti i autoimunog hepatitisa) također je bila prijavljena; međutim, prijavljeno vrijeme do nastanka je jako varijabilno, te ovi događaji mogu nastati puno mjeseci nakon početka liječenja (vidjeti dio 4.4).
English: Pooled DUET Studies ≥ 18 years ETR N = 599
Croatian: Udružena DUET ispitivanja ≥ 18 godina ETR N = 599
English: Patients who are diagnosed with a hypersensitivity reaction whilst on therapy must discontinue INTELENCE immediately.
Croatian: Bolesnici kojima se dijagnosticira reakcija preosjetljivosti za vrijeme terapije moraju odmah prekinuti uzimati INTELENCE.
English: Effects on drug levels Least Squares Mean Ratio (90% CI; 1.00 = No effect)
Croatian: (90% CI; 1,00 = bez učinka)
English: Paediatric population (6 years to less than 18 years of age) The recommended dose of etravirine for paediatric patients (6 years to less than 18 years of age and weighing at least 16 kg) is based on body weight (see table below).
Croatian: Pedijatrijska populacija (u dobi od 6 godina do manje od 18 godina) Preporučena doza etravirina za pedijatrijske bolesnike (u dobi od 6 godina do manje od 18 godina i težine najmanje 16 kg) temeljeno je na tjelesnoj težini (vidjeti tablicu ispod).
English: CCR5 Antagonists Maraviroc 300 mg twice daily
Croatian: CCR5 antagonisti Maravirok 300 mg dva puta dnevno
English: Etravirine is excreted in human milk.
Croatian: Etravirin se izlučuje u majčino mlijeko.
English: If you vomit less than 4 hours after taking INTELENCE, take another dose following a meal.
Croatian: Ako povraćate nakon manje od 4 sata nakon uzimanja lijeka INTELENCE, uzmite drugu dozu nakon obroka.
English: Posaconazole, a potent inhibitor of CYP3A4, may increase plasma concentrations of etravirine.
Croatian: Posakonazol, snažan inhibitor enzima CYP3A4, može povećati plazmatske koncentracije etravirina.
English: It is recommended that digoxin levels be monitored when digoxin is combined with INTELENCE.
Croatian: Preporučuje se nadzor razina digoksina kada se digoksin kombinira s lijekom INTELENCE.
English: An increase in the incidences of hepatocellular adenomas and carcinomas were observed in female mice.
Croatian: U ženki miša opaženo je povećanje incidencije hepatocelularnog adenoma i karcinoma.
English: Amprenavir/ritonavir and fosamprenavir/ritonavir may require dose reduction when co-administered with INTELENCE.
Croatian: Amprenavir/ritonavir i fosamprenavir/ritonavir mogu tražiti smanjenje doze kad se primjenjuju istodobno s INTELENCE-om.
English: Table 3: DUET-1 and DUET-2 pooled 48-week data Etravirine + BR N = 599
Croatian: Tablica 3: Objedinjeni 48-tjedni podaci za DUET-1 i DUET-2 etravirin + BR N = 599
English: Patients who have stopped treatment due to hypersensitivity reactions should not restart therapy with INTELENCE.
Croatian: Bolesnici koji su prekinuli liječenje zbog reakcija preosjetljivosti ne smiju ponovo započeti terapiju s lijekom INTELENCE.
English: Renal impairment No dose adjustment is required in patients with renal impairment (see section 5.2).
Croatian: Nije potrebna prilagodba doze u bolesnika s oštećenjem bubrega (vidjeti dio 5.2).
English: No dose adjustment is needed for INTELENCE.
Croatian: Nije potrebna prilagodba doze za INTELENCE.
English: - Treatment: Etravirine vs. placebo, in addition to a background regimen (BR) including darunavir/ritonavir (DRV/rtv), investigator-selected N(t)RTIs and optional enfuvirtide (ENF).
Croatian: - Način liječenja: etravirin u usporedbi s placebom, uz osnovno liječenje (BR) koje uključuje darunavir/ritonavir (DRV/rtv), N(t)RTI prema izboru ispitivača i enfuvirtid (ENF) po izboru.
English: Cases of severe hypersensitivity syndromes, including DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) and TEN (toxic epidermal necrolysis), sometimes fatal, have been reported with the use of etravirine (see section 4.8).
Croatian: Pri primjeni etravirina prijavljeni su slučajevi teških sindroma preosjetljivosti, uključujući DRESS sindrom (kožni osip uzrokovan lijekom s eozinofilijom i sistemskim simptomima) i TEN (toksična epidermalna nekroliza), koji su ponekad bili smrtonosni (vidjeti dio 4.8).
English: Do not remove the desiccant pouches.
Croatian: Nemojte uklanjati vrećice sa sredstvom za sušenje.
English: Etravirine has not been studied in patients with severe hepatic impairment (Child-Pugh Class C) and its use is therefore not recommended in this group of patients (see sections 4.2 and 5.2).
Croatian: Etravirin nije ispitivan kod bolesnika s teškim oštećenjem jetre (Child-Pugh stadij C) stoga se njegova primjena ne preporučuje u toj skupini bolesnika (vidjeti dijelove 4.2 i 5.2).
English: The recommended dose of INTELENCE is one tablet twice a day.
Croatian: Preporučena doza lijeka INTELENCE je jedna tableta dva puta dnevno.
English: Not studied, but no interaction expected based on the primary renal elimination route for other NRTIs (e.g., abacavir, emtricitabine, lamivudine, stavudine and zidovudine).
Croatian: Nije ispitano, ali interakcija se ne očekuje s obzirom na to da se ostali NRTI (npr. abakavir, emtricitabin, lamivudin, stavudin i zidovudin) izlučuju primarno putem bubrega.
English: Etravirine had no effect on offspring development during lactation or post weaning at maternal exposures equivalent to those observed at the recommended clinical dose.
Croatian: Etravirin nije imao učinka na razvoj mladunčadi za vrijeme ili nakon prestanka sisanja u slučaju kada je majka bila izložena jednakoj onoj opaženoj pri preporučenim kliničkim dozama.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.8).
Croatian: Pojava autoimunih poremećaja (poput Gravesove bolesti i autoimunog hepatitisa) također je bila prijavljena prilikom imunološke reaktivacije; međutim, prijavljeno vrijeme do nastanka je jako varijabilno, te ovi događaji mogu nastati puno mjeseci nakon početka liječenja (vidjeti dio 4.8).
English: The effect of etravirine on dolutegravir plasma concentrations was mitigated by co-administration of darunavir/ritonavir or lopinavir/ritonavir, and is expected to be mitigated by atazanavir/ritonavir.
Croatian: Učinak etravirina na koncentracije dolutegravira u plazmi ublažen je istodobnom primjenom darunavira/ritonavira ili lopinavira/ritonavira i očekuje se da će biti ublažen atazanavirom/ritonavirom.
English: OESTROGEN-BASED CONTRACEPTIVES Ethinylestradiol
Croatian: NA BAZI ESTROGENA Etinilestradiol
English: In vitro data show that etravirine has inhibitory properties on CYP2C19.
Croatian: In vitro podaci pokazuju da etravirin pokazuje inhibiciju prema CYP2C19.
English: The combination of etravirine with simeprevir, daclatasvir, atazanavir/cobicistat or darunavir/cobicistat is not recommended (see section 4.5).
Croatian: Istodobna primjena etravirina sa simeprevirom, daklatasvirom, atazanavir/kobicistatom ili darunavir/kobicistatom se ne preporučuje (vidjeti dio 4.5)
English: How to store INTELENCE
Croatian: Kako čuvati INTELENCE
English: 6 cells/l.
Croatian: 6 stanica/l.
English: This combination can be used without dose adjustment.
Croatian: Ova kombinacija se može uzimati bez prilagodbe doze.
English: In HIV infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: Kod bolesnika zaraženih HIV-om s teškom imunodeficijencijom u vrijeme uvođenja kombinirane antiretrovirusne terapije (KART) može nastati upalna reakcija na asimptomatske ili rezidualne oportunističke infekcije.
English: In the TMC125-C227 study, etravirine (N = 59) was administered with 2 investigator-selected NRTIs (i.e. without a ritonavir-boosted PI) and compared to an investigator-selected combination of a PI with 2 NRTIs (N = 57).
Croatian: U ispitivanju TMC125-C227, etravirin (N = 59) je primjenjivan uz 2 NRTI prema izboru ispitivača (tj. bez IP pojačanih ritonavirom) i uspoređen s kombinacijom inhibitora proteaze i 2 NRTI
English: Co-administration with systemic immunosuppressants should be done with caution because plasma concentrations of cyclosporin, sirolimus and tacrolimus may be affected when co-administered with INTELENCE.
Croatian: Istovremena primjena sa sustavnim imunosupresantima treba se izvršiti s oprezom, budući da može doći do utjecaja na koncentraciju ciklosporina, sirolimusa ili takrolimusa u plazmi kad se primjenjuju istodobno s lijekom INTELENCE
English: Remove the unscrewed cap.
Croatian: Uklonite zatvarač.
English: 40 mg once daily atorvastatin
Croatian: 40 mg jedanput dnevno atorvastatin
English: Immune reconstitution syndrome
Croatian: Sindrom imunološke rekonstitucije