FrancophonIA/ELRC3.0 huggingface dataset:
English: (based on AUC) to etravirine were 0.6-fold (mice) and between 0.2- and 0.7-fold (rats), relative to those observed in humans at the recommended therapeutic dose (200 mg twice daily).
Danish: Den systemiske eksponering (baseret på AUC) med etravirin ved de højeste afprøvede doser var 0,6 gange (for mus) og mellem 0,2 og 0,7 gange (for rotter) i forhold til den, der blev observeret hos mennesker ved den anbefalede terapeutiske dosis (200 mg 2 gange dagligt).
English: Table 2: Adverse reactions observed with etravirine in clinical trials and post-marketing experience
Danish: Tabel 2: Bivirkninger observeret med etravirin i kliniske forsøg og ved erfaringer efter markedsføring Systemorganklasse Hyppighedskategori
English: - If you are unable to swallow the INTELENCE tablet(s) whole, you may do the following: place the tablet(s) in 5 ml (1 teaspoon) of water, or at least enough liquid to cover the medicine, stir well until the water looks milky, if desired, add more water or alternatively orange juice or milk (do not place the tablets directly in orange juice or milk), drink it immediately, rinse the glass several times with water, orange juice, or milk and completely swallow the rinse each time to make sure you take the entire dose.
Danish: - Hvis du ikke kan synke tabletterne hele, kan du gøre følgende: læg tabletten/tabletterne i 5 ml (1 teske) vand, eller nok til at medicinen er dækket, - rør godt rundt i vandet, indtil blandingen har et mælkeagtigt udseende, - du kan eventuelt tilsætte mere vand, eller i stedet tilsætte appelsinjuice eller mælk (læg ikke tabletterne direkte i appelsinjuice eller mælk), - drik med det samme, - skyl glasset grundigt flere gange med vand, appelsinjuice eller mælk, og drik al skyllevandet hver gang, så du er sikker på at få hele dosen.
English: Posaconazole, a potent inhibitor of CYP3A4, may increase plasma concentrations of etravirine.
Danish: Posaconazol, en potent CYP3A4-hæmmer, kan øge plasmakoncentrationen af etravirin.
English: Manufacturer Janssen-Cilag SpA, Via C. Janssen, 04100 Borgo San Michele, Latina, Italy
Danish: Fremstiller Janssen-Cilag SpA, Via C. Janssen, I-04100 Borgo San Michele, Latina, Italien
English: Carbazamepine, phenobarbital and phenytoin are expected to decrease plasma concentrations of etravirine.
Danish: Carbazamepin, phenobarbital og phenytoin forventes at reducere plasmakoncentrationen af etravirin.
English: Psychiatric disorders common anxiety, insomnia, sleep disorders uncommon confusional state, disorientation, nightmares,
Danish: Psykiatriske forstyrrelser almindelig angst, insomni, søvnforstyrrelser ikke almindelig konfusion, desorientering, mareridt, nervøsitet, unormale drømme
English: INTELENCE, in combination with a boosted protease inhibitor and other antiretroviral medicinal products, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients and in antiretroviral treatment-experienced paediatric patients from 6 years of age (see sections 4.4, 4.5 and 5.1).
Danish: I kombination med en boosted proteasehæmmer og andre antiretrovirale lægemidler er INTELENCE indiceret til behandling af infektion med humant immundefektvirus type 1 (hiv-1) hos voksne patienter med antiretroviral behandlingserfaring og pædiatriske patienter over 6 år med antiretroviral behandlingserfaring (se pkt.
English: No dose adjustment is needed for INTELENCE.
Danish: Dosisjustering er ikke påkrævet for INTELENCE.
English: Do not remove the desiccant pouches.
Danish: Fjern ikke poserne med tørremiddel.
English: No significant effect on didanosine and etravirine PK parameters is seen.
Danish: Der ses ingen signifikant virkning på didanosins eller etravirins farmakokinetiske parametre.
English: Co-administration of etravirine with atazanavir/cobicistat or darunavir/cobicistat may decrease plasma concentrations of the PI and/or cobicistat, which may result in loss of therapeutic effect and development of resistance.
Danish: Samtidig administration af etravirin med atazanavir/cobicistat eller darunavir/cobicistat kan reducere plasmakoncentrationerne for proteasehæmmerne og/eller cobicistat, hvilket kan medføre tabt behandlingsvirkning og udvikling af resistens.
English: Co-administration of etravirine with elbasvir/grazoprevir may decrease elbasvir and grazoprevir concentrations, leading to reduced therapeutic effect of elbasvir/grazoprevir.
Danish: Samtidig administration af etravirin med elbasvir/grazoprevir kan reducere koncentrationerne af elbasvir og grazoprevir, hvilket medfører nedsat behandlingsvirkning for elbasvir/grazoprevir.
English: This combination can be used without dose adjustment.
Danish: Denne kombination kan anvendes uden dosisjustering.
English: The recommended dose of INTELENCE is one tablet twice a day.
Danish: Den anbefalede dosis INTELENCE er en tablet to gange dagligt.
English: Most frequently, rash was mild to moderate, occurred in the second week of therapy, and was infrequent after week 4.
Danish: I de fleste tilfælde var udslættet let til moderat, optrådte i den anden uge af behandlingen og optrådte sjældent efter fjerde uge.
English: The plastic bottle comes with a child resistant cap and should be opened as follows: Push the plastic screw cap down while turning it counter clockwise.
Danish: Beholderen er forsynet med et børnesikret låg, der fjernes på følgende måde: - Tryk låget ned, samtidig med at du drejer det mod uret.
English: The recommended dose of INTELENCE is two tablets twice a day.
Danish: Den anbefalede dosis INTELENCE er to tabletter to gange dagligt.
English: Etravirine has not been studied in patients with severe hepatic impairment (Child-Pugh Class C) and its use is therefore not recommended in this group of patients (see sections 4.2 and 5.2).
Danish: Etravirin er ikke undersøgt hos patienter med svært nedsat leverfunktion (Child-Pugh-klasse C), og brugen anbefales derfor ikke til denne patientgruppe (se pkt.
English: How to take INTELENCE
Danish: Sådan skal du tage INTELENCE
English: If a patient vomits within 4 hours of taking the medicine, another dose of INTELENCE should be taken following a meal as soon as possible.
Danish: Hvis patienten kaster op inden for 4 timer efter at have indtaget lægemidlet, skal vedkommende tage en ny dosis INTELENCE efter et måltid så hurtigt som muligt.
English: It is not recommended to co-administer INTELENCE with other NNRTIs.
Danish: Det frarådes at indgive INTELENCE samtidig med andre NNRTI-midler.
English: The DRESS syndrome is characterised by rash, fever, eosinophilia and systemic involvement (including, but not limited to, severe rash or rash accompanied by fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis and eosinophilia).
Danish: DRESSsyndromet er karakteriseret ved udslæt, feber, eosinofili og systemisk påvirkning (inklusive, men ikke begrænset til, alvorligt udslæt eller udslæt i forbindelse med feber, generel svækkelse, træthed, muskel- eller ledsmerter, blærer, læsioner i mundhulen, konjunktivitis, hepatitis og eosinofili).
English: Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section 4.4)
Danish: Kropsvægt og niveauerne af lipid og glucose i blodet kan stige under antiretroviral behandling (se pkt.
English: ≥ 16 to < 20 kg
Danish: ≥ 16 til < 20 kg
English: Etravirine is metabolised by CYP3A4, CYP2C9 and CYP2C19 followed by glucuronidation of the metabolites by uridine diphosphate glucuronosyl transferase (UDPGT).
Danish: Etravirin metaboliseres af CYP3A4, CYP2C9 og CYP2C19 efterfulgt af glukuronidering af metabolitterne via uridindifosfatglucuronosyltransferase (UDPGT).
English: Pharmacokinetics of etravirine
Danish: Farmakokinetik for etravirin
English: Confirmed undetectable viral load (< 50 HIV-1 RNA copies/ml) n (%)
Danish: Bekræftet udetekterbar virusmængde (< 50 hiv-1 RNA kopier/ml) n (%)
English: Table 5: Proportion of subjects with < 50 HIV-1 RNA copies/ml at week 48 by baseline number of etravirine RAMs in the non-viral failure excluded population of pooled DUET-1 and DUET-2 trials Baseline number of Etravirine RAMs*
Danish: Tabel 5: Andel af patienter med < 50 hiv-1 RNA kopier/ml i uge 48 efter baselineantal af etravirin-resistensassocierede mutationer i den ekskluderede population bestående af patienter uden virologisk svigt i poolede data fra DUET-1 og DUET-2 Antal etravirinresistensassocierede mutationer* ved baseline
English: Population pharmacokinetic analysis of the DUET-1 and DUET-2 trials showed reduced clearance (potentially leading to increased exposure and alteration of the safety profile) for etravirine in HIV-1 infected patients with hepatitis B and/or hepatitis C virus co-infection.
Danish: Samtidig infektion med hepatitis B- og/eller hepatitis C-virus Den farmakokinetiske populationsanalyse i DUET-1 og DUET-2 viste nedsat clearance (som potentielt kan føre til øget eksponering og ændring af sikkerhedsprofilen) af etravirin hos hiv-1 inficerede patienter, som samtidig var inficeret med hepatitis B- og/eller hepatitis C-virus.
English: Concomitant use of etravirine with simeprevir may decrease plasma concentrations of simeprevir.
Danish: Samtidig brug af etravirin med simeprevir kan reducere plasmakoncentrationerne af simeprevir.
English: In most cases, INTELENCE can be combined with anti-HIV medicines belonging to another class.
Danish: INTELENCE kan i de fleste tilfælde kombineres med andre typer hiv-medicin.
English: If you notice within 6 hours of the time you usually take INTELENCE, you must take the tablet as soon as possible.
Danish: Hvis du bemærker det inden for 6 timer efter det tidspunkt, hvor du normalt tager INTELENCE, skal du tage tabletten så hurtigt som muligt.
English: Viral load < 400 copies/ml at week 24, n (%)
Danish: Viral load < 400 kopier/ml i uge 24, n (%)
English: In all the other trials conducted with etravirine in HIV-1 infected patients, the following mutations emerged most commonly: L100I, E138G, V179F, V179I, Y181C and H221Y.
Danish: I samtlige andre forsøg med etravirin til hiv-1-inficerede patienter var følgende mutationer de mest almindelige: L100I, E138G, V179F, V179I, Y181C og H221Y.
English: It is not recommended to co-administer INTELENCE with nelfinavir.
Danish: Det frarådes at indgive INTELENCE samtidig med nelfinavir.
English: In vitro data show that etravirine has inhibitory properties on CYP2C19.
Danish: In vitro-data viser, at etravirin virker hæmmende på CYP2C19.
English: Baseline HIV-1 RNA < 30,000 copies/ml ≥ 30,000 and < 100,000 copies/ml ≥ 100,000 copies/ml Baseline CD4 count (x 10
Danish: hiv-1 RNA ved baseline < 30.000 kopier/ml ≥ 30.000 og < 100.000 kopier/ml ≥ 100.000 kopier/ml
English: HIV PIs - Boosted with low-dose ritonavir Atazanavir/ritonavir
Danish: Boostede hiv-proteasehæmmere med lavdosis ritonavir Atazanavir/ritonavir
English: Viral load < 50 copies/ml at week 24, n (%)
Danish: Viral load < 50 kopier/ml i uge 24, n (%)
English: No significant effect on tenofovir and etravirine PK parameters is seen.
Danish: Der ses ingen signifikant virkning på tenofovirs eller etravirins farmakokinetiske parametre.
English: Change from baseline in log10 viral load (copies/ml) at week 24, mean (SE) and median (range)
Danish: Ændring fra baseline i log10 viral load (kopier/ml) i uge 24, gennemsnit (SE) og median (interval)
English: Swallow the INTELENCE tablet(s) whole with a glass of water.
Danish: Synk INTELENCE tablet eller tabletter hele med et glas vand.
English: There is limited information regarding the use of INTELENCE in patients > 65 years of age (see section 5.2), therefore caution should be used in this population.
Danish: Der er begrænset information vedrørende brug af INTELENCE til patienter over 65 år (se pkt.
English: The pharmacokinetics of etravirine have not been studied in patients with renal insufficiency.
Danish: Etravirins farmakokinetiske egenskaber er ikke undersøgt hos patienter med nyreinsufficiens.
English: Etravirine 200 mg twice daily N = 575
Danish: Etravirin 200 mg to gange dagligt N = 575
English: Confidence interval around observed difference of response rates; P-value < 0.0001 from logistic regression model, including stratification factors.
Danish: P-værdi < 0,0001 fra logistisk regressionsmodel, som inkluderer stratificeringsfaktorer.
English: Co-administration of etravirine with medicinal products primarily metabolised by CYP3A4 may result in decreased plasma concentrations of such medicinal products, which could decrease or shorten their therapeutic effects.
Danish: Samtidig indgift af etravirin og lægemidler, som primært metaboliseres af CYP3A4, kan resultere i en reduktion af plasmakoncentrationen af disse lægemidler, hvilket kan reducere eller forkorte deres terapeutiske virkning.
English: Please refer to the product information of the associated boosted PI for the dose adjustment of rifabutin to be used.
Danish: Find venligst informationer om dosisjusteringsanbefalinger for rifabutin i produktinformationen for den tilknyttede boostede PI.
English: Based on animal data the malformative risk is unlikely in humans.
Danish: Ud fra dyredata er der sandsynligvis ikke risiko for misdannelser hos mennesker.
English: Tell your doctor if you take: - dolutegravir, maraviroc, amprevanir/ritonavir and fosamprenavir/ritonavir (anti-HIV medicine) - amiodarone, bepridil, digoxin, disopyramide, flecainide, lidocaine, mexiletine, propafenone and quinidine (medicines to treat certain heart disorders, e.g., abnormal heart beat) - warfarin (a medicine used to reduce clotting of the blood).
Danish: Fortæl det til lægen, hvis du tager: - dolutegravir, maraviroc, amprenavir/ritonavir og fosamprenavir/ritonavir (medicin mod hiv) - amiodaron, bepridil, digoxin, disopyramid, flecainid, lidocain, mexiletin, propafenon eller quinidin (til behandling af visse hjertesygdomme, bl.a. uregelmæssig puls) - warfarin (blodfortyndende medicin).
English: Vascular disorders common hypertension rare haemorrhagic stroke
Danish: Vaskulære sygdomme almindelig hypertension sjældne hæmorrhagia cerebri
English: NNRTIs Efavirenz Nevirapine Rilpivirine
Danish: NNRTI-midler Efavirenz Nevirapin Rilpivirin
English: Each tablet contains less than 1 mmol sodium (23 mg), and is essentially sodium-free.
Danish: Hver tablet indeholder mindre end 1 mmol (23 mg) natrium og er i det væsentlige natriumfri.
English: Metabolism and nutrition disorders common diabetes mellitus, hyperglycaemia, hypercholesterolaemia, increased low density lipoprotein (LDL), hypertriglyceridaemia, hyperlipidaemia, dyslipidaemia, anorexia
Danish: Metabolisme og ernæring almindelig diabetes mellitus, hyperglykæmi, hyperkolesterolæmi, forhøjet lavdensitetslipoprotein (LDL), hypertriglyceridæmi, hyperlipidæmi, dyslipidæmi, appetitmangel
English: Paediatric population (6 years to less than 18 years of age) The pharmacokinetics of etravirine in 101 treatment-experienced HIV-1 infected paediatric patients, 6 years to less than 18 years of age and weighing at least 16 kg, showed that the administered weight-based dosages resulted in etravirine exposure comparable to that in adults receiving etravirine 200 mg twice daily (see sections 4.2 and 5.2) when administered at a dose corresponding to 5.2 mg/kg twice daily.
Danish: Pædiatrisk population (i alderen 6 år til yngre end 18 år) Etravirins farmakokinetik hos 101 behandlingserfarne hiv-1-inficerede pædiatriske patienter i alderen 6 år til yngre end 18 år og med en legemsvægt på mindst 16 kg viste, at de administrerede vægtbaserede doseringer resulterede i en eksponering for etravirin, der var sammenlignelig med eksponeringen hos voksne, der fik etravirin 200 mg to gange dagligt (se pkt.
English: If a patient misses a dose by more than 6 hours of the time it is usually taken, the patient should not take the missed dose and simply resume the usual dosing schedule.
Danish: Hvis en patient glemmer at tage en dosis mere end 6 timer efter det tidspunkt, hvor den normalt tages, skal patienten ikke at tage den glemte dosis og blot fortsætte med den sædvanlige dosis.
English: The mean change in plasma HIV-1 RNA from baseline to week 48 was -1.53 log10 copies/ml, and the mean CD4 cell count increase from baseline was 156 x 10
Danish: Den gennemsnitlige ændring i hiv-1 RNA i plasma fra baseline til uge 48 var -1,53 log10 kopier/ml, og den gennemsnitlige stigning i CD4-celletal fra baseline var 156 x 10
English: Removing the child resistant cap
Danish: Sådan fjernes det børnesikre låg
English: Etravirine significantly reduced plasma concentrations of dolutegravir.
Danish: Etravirin reducerer plasmakoncentrationen af dolutegravir signifikant.
English: INTELENCE should only be used with dolutegravir when co-administered with atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir.
Danish: INTELENCE må udelukkende anvendes med dolutegravir, når det indgives samtidigt med atazanavir/ritonavir, darunavir/ritonavir eller lopinavir/ritonavir.
English: Saquinavir/ritonavir 1,000/100 mg twice daily saquinavir
Danish: Saquinavir/ritonavir 1.000/100 mg to gange dagligt saquinavir
English: Co-administration of INTELENCE with atazanavir/cobicistat or darunavir/cobicistat is not recommended.
Danish: Samtidig administration af INTELENCE med atazanavir/cobicistat eller darunavir/cobicistat frarådes.
English: INTELENCE tablet(s) should be taken orally, following a meal (see section 5.2).
Danish: INTELENCE tablet/tabletter bør indtages per os efter et måltid (se pkt.
English: It is not recommended to combine INTELENCE with any of the following medicines: - tipranavir/ritonavir, efavirenz, nevirapine, rilpivirine, indinavir, nelfinavir, atazanavir/cobicistat,
Danish: INTELENCE bør ikke kombineres med følgende medicin: - tipranavir/ritonavir, efavirenz, nevirapin, rilpivirin, indinavir, nelfinavir, atazanavir/cobicistat,
English: Each subject served as her own control, and with an intra-individual comparison, the total etravirine Cmin, Cmax and AUC12h values were 1.2-, 1.4- and 1.4-fold higher, respectively, during the 2
Danish: Hver forsøgsperson var sin egen kontrolperson, og ved intraindividuel sammenligning var Cmin, Cmax og AUC12t for total-etravirin hhv. 1,2, 1,4 og 1,4 gange højere i andet trimester i graviditeten i forhold til post partum og hhv. 1,1, 1,4 og 1,2 gange højere i tredje trimester i graviditeten i forhold til post partum.
English: Cmax ↑ 1.76 (1.60-1.94) etravirine
Danish: Cmax ↑ 1,76 (1,60-1,94) etravirin
English: There was no teratogenicity with etravirine in rats and rabbits at exposures equivalent to those observed in humans at the recommended clinical dose.
Danish: Der var ingen teratogenicitet med etravirin hos rotter eller kaniner ved eksponeringer svarende til eksponeringsniveauer hos mennesker ved den anbefalede kliniske dosis.
English: Not de novo ENF
Danish: Ikke de novo ENF
English: It is not recommended to co-administer INTELENCE with indinavir.
Danish: Det frarådes at indgive INTELENCE samtidig med indinavir.
English: The effect of etravirine on dolutegravir plasma concentrations was mitigated by co-administration of darunavir/ritonavir or lopinavir/ritonavir, and is expected to be mitigated by atazanavir/ritonavir.
Danish: Etravirins effekt på dolutegravirplasmakoncentrationen blev mindsket ved samtidig indgift af darunavir/ritonavir eller lopinavir/ritonavir og forventes at blive mindsket af atazanavir/ritonavir.
English: Rare side effects (may affect up to 1 in 1,000 people) - stroke; - severe skin rash with blisters or peeling skin, particularly around the mouth or eyes; this may occur in children and adolescents more frequently than in adults.
Danish: Sjældne bivirkninger (kan forekomme hos op til 1 ud af 1.000 personer) - slagtilfælde - alvorligt hududslæt med blærer eller afskalning af huden, især omkring munden eller øjnene.
English: Co-administration of etravirine with daclatasvir may decrease daclatasvir concentrations.
Danish: Samtidig administration af etravirin med daclatasvir kan reducere koncentrationerne af daclatasvir.
English: Immune system disorders common drug hypersensitivity uncommon immune reconstitution syndrome
Danish: Immunsystemet almindelig lægemiddeloverfølsomhed ikke almindelig immunreaktiveringssyndrom
English: Didanosine 400 mg once daily didanosine
Danish: 400 mg en gang dagligt didanosin
English: Table 9: Pharmacokinetic results of total etravirine after administration of etravirine 200 mg twice daily as part of an antiretroviral regimen, during the 2
Danish: Tabel 9: Farmakokinetiske resultater for total-etravirin efter administration af 200 mg etravirin to gange dagligt som del af et antiretroviralt regime i andet og tredje trimester af graviditeten og post partum.
English: In the Phase III trials DUET-1 and DUET-2, mutations that developed most commonly in patients with virologic failure to the etravirine containing regimen were V108I, V179F, V179I, Y181C and Y181I, which usually emerged in a background of multiple other NNRTI resistance-associated mutations (RAMs).
Danish: I fase III-forsøgene DUET-1 og DUET-2 var de mutationer, som oftest blev udviklet hos patienter med virologisk svigt over for etravirin-regimet V108I, V179F, V179I, Y181C og Y181I, som normalt opstod sammen med flere andre NNRTI-resistensassocierede mutationer (RAM).
English: INTELENCE contains lactose
Danish: INTELENCE indeholder lactose
English: The median baseline plasma HIV-1 RNA was 3.9 log10 copies/ml, and the median baseline CD4 cell count was 385 x 10
Danish: Median hiv-1 RNA i plasma ved baseline var 3,9 log10 kopier/ml, og mediant CD4-celletal var 385 x 10
English: 40 mg once daily atorvastatin
Danish: 40 mg en gang dagligt atorvastatin
English: HMG CO-A REDUCTASE INHIBITORS Atorvastatin
Danish: HMG-COA-REDUKTASEHÆMMERE Atorvastatin
English: Dolutegravir + darunavir/ritonavir 50 mg once daily + 600/100 mg twice daily
Danish: Dolutegravir + darunavir/ritonavir 50 mg en gang dagligt + 600/100 mg to gange dagligt
English: INTELENCE tablets should be stored in the original bottle and keep the bottle tightly closed in order to protect from moisture.
Danish: Opbevar INTELENCE-tabletterne i den originale beholder og hold beholderen tæt tillukket for at beskytte mod fugt.
English: Respiratory, thoracic and mediastinal disorders common exertional dyspnoea uncommon bronchospasm
Danish: Luftveje, thorax og mediastinum almindelig anstrengelsesdyspnø ikke almindelig bronkospasme
English: In a study conducted in rats, there were no effects on mating or fertility at exposure levels equivalent to those in humans at the clinically recommended dose.
Danish: I et forsøg med rotter var der ingen effekt på parring eller fertilitet ved eksponeringsniveauer svarende til eksponeringsniveauer hos mennesker ved den klinisk anbefalede dosis.
English: INTELENCE 25 mg tablets INTELENCE 100 mg tablets INTELENCE 200 mg tablets
Danish: INTELENCE 25 mg tabletter INTELENCE 100 mg tabletter INTELENCE 200 mg tabletter
English: The combination of oestrogen- and/or progesterone-based contraceptives and INTELENCE can be used without dose adjustment.
Danish: Østrogen- og/eller progesteronbaserede antikonceptiva og INTELENCE kan gives i kombination uden dosisjustering.
English: In a study comparing 8 patients with mild (Child-Pugh Class A) hepatic impairment to 8 matched controls and 8 patients with moderate (Child-Pugh Class B) hepatic impairment to 8 matched controls, the multiple dose pharmacokinetic disposition of etravirine was not altered in patients with mild to moderate hepatic impairment.
Danish: I et forsøg blev otte patienter med let nedsat leverfunktion (Child-Pugh-klasse A) sammenlignet med otte matchede kontrolforsøgspersoner, og otte patienter med moderat nedsat leverfunktion (Child-Pugh-klasse B) blev sammenlignet med otte matchede kontrolforsøgspersoner ved gentagne doseringer.