FrancophonIA/ELRC3.0 huggingface dataset:
English: Frequency not known: Transient neurological symptoms (i.e. hypoesthesia, muscle spasm, paraesthesia, difficulty in walking, musculoskeletal stiffness) that may mimic multiple sclerosis exacerbations*
Croatian: Prolazni neurološki simptomi (primjerice, hipoestezija, spazam mišića, parestezija, poteškoće u hodanju, ukočenost mišića i kostiju) koji mogu imitirati simptome pogoršanja multiple skleroze*
English: Rebif (interferon beta-1a) shares the same amino acid sequence with endogenous human interferon beta.
Croatian: Rebif (interferon beta-1a) se sastoji od istog slijeda aminokiselina kao i endogeni humani interferon beta.
English: Over 4 years, the reduction in the mean exacerbation rate was 22% in patients treated with Rebif 22 micrograms, and 29% in patients treated with Rebif 44 micrograms group compared with a group of patients treated with placebo for 2 years and then either Rebif 22 or Rebif 44 micrograms for 2 years.
Croatian: Tijekom 4 godine, smanjenje srednje vrijednosti stope egzacerbacija u grupi bolesnika liječenih s Rebifom 22 mikrograma bilo je 22%, odnosno 29% u grupi bolesnika liječenih s Rebifom 44 mikrograma u usporedbi s grupom bolesnika koji su primali placebo 2 godine i nakon toga 2 godine nastavili primati Rebif 22 ili Rebif 44 mikrograma.
English: Clear to opalescent solution, with pH 3.7 to 4.1 and osmolarity 250 to 450 mOsm/L.
Croatian: Bistra do opalescentna otopina, uz pH 3,7 do 4,1 i osmolarnost 250 do 450 mOsm/l.
English: You should discuss this with your doctor if you are concerned.
Croatian: Ako ste zabrinuti, razgovarajte o tome sa svojim liječnikom.
English: Injection site cellulitis*
Croatian: Celulitis na mjestu injiciranja*
English: It is recommended that you keep track of and rotate your injection sites, so that one area is not injected too frequently in order to minimise the risk of injection site necrosis.
Croatian: Preporučuje se da pratite gdje injicirate te mijenjate mjesto injiciranja kako bi se izbjeglo previše često injiciranje na jednom području i smanjio rizik od oštećenja tkiva (nekroza) na mjestu injiciranja.
English: This medicine is for multidose use.
Croatian: Ovaj lijek je za višedoznu primjenu.
English: Titration dose for Rebif 44 micrograms three times per week (tiw)
Croatian: Titracija doze za Rebif 44 mikrograma tri puta tjedno
English: Clear to opalescent solution, with pH 3.5 to 4.5 and osmolarity 250 to 450 mOsm/L.
Croatian: Bistra do opalescentna otopina, uz pH 3,5 do 4,5 i osmolarnost 250 do 450 mOsm/l.
English: Marketing Authorisation Holder Merck Europe B.V.
Croatian: Nositelj odobrenja za stavljanje lijeka u promet Merck Europe B.V.
English: Rebif is administered by subcutaneous injection.
Croatian: Rebif se primjenjuje supkutanom injekcijom.
English: • Injection site reactions including redness, swelling, discoloration, inflammation, pain and skin breakdown are very common.
Croatian: • Reakcije na mjestu injiciranja, a koje uključuju crvenilo, oticanje promjenu boje, upalu, bol i propadanje kože su vrlo česte.
English: No information is available on the effects of the interferon beta-1a on male fertility.
Croatian: Nema podataka o djelovanju interferona beta-1a na plodnost muškaraca.
English: Diarrhoea, vomiting, nausea Skin and subcutaneous tissue disorders Common:
Croatian: Proljev, povraćanje, mučnina Poremećaji kože i potkožnog tkiva Često:
English: It may cause toxic reactions and allergic reactions in infants and children up to 3 years old.
Croatian: Može uzrokovati toksične reakcije i alergijske reakcije u dojenčadi i djece do 3 godine starosti.
English: • When you do this please read carefully and follow the “RebiDose Instructions for Use” provided separately in the booklet.
Croatian: • Kada to učinite, pozorno pročitajte „Upute za upotrebu uređaja RebiDose“ koje se nalaze zasebno u brošuri te ih se pridržavajte.
English: If you are uncertain about the benefits, please consult your doctor.
Croatian: Ako niste sigurni u korisnost lijeka, obratite se svom liječniku.
English: (UPPER FLAP) 6 pre-filled pens RebiDose
Croatian: (GORNJI PREKLOP) 6 napunjenih brizgalica RebiDose
English: Primary progressive multiple sclerosis
Croatian: Primarna progresivna multipla skleroza
English: Injection site necrosis (ISN) has been reported in patients using Rebif (see section 4.8).
Croatian: Nekroza na mjestu injiciranja opisana je kod bolesnika koji primaju Rebif (vidjeti dio 4.8).
English: The first injection(s) must be performed under the supervision of an appropriately qualified healthcare professional.
Croatian: Davanje prve injekcije mora se provesti pod nadzorom odgovarajuće osposobljenog zdravstvenog djelatnika.
English: • Place RebiSmart at a right angle (90°) to the skin.
Croatian: • Položite RebiSmart pod pravim kutom (90°) na kožu.
English: No interaction studies have been performed with interferon beta-1a in humans.
Croatian: Nisu provedena ispitivanja interakcija s interferonom beta-1a kod ljudi.
English: The proportion of patients with disability progression, as defined by at least one point increase in EDSS confirmed three months later, was reduced from 39% (placebo) to 27% (Rebif 44 micrograms).
Croatian: Udio bolesnika s napredovanjem onesposobljenosti utvrđenim povećanjem od barem jednog boda na ljestvici stanja širenja onesposobljenosti (Expanded Disability Status Scale, EDSS) potvrđenim 3 mjeseca kasnije smanjen je s 39% (placebo) na 27% (Rebif 44 mikrograma).
English: Rebif is available in packs of 1, 3 and 12 pre-filled pens (RebiDose).
Croatian: Rebif je dostupan u pakiranjima od 1, 3 i 12 napunjenih brizgalica (RebiDose).
English: INFORMATION IN BRAILLE rebif 8.8/0.1 / 22/0.25
Croatian: 16. PODACI NA BRAILLEOVOM PISMU rebif 8,8/0,1 / 22/0,25
English: • a dry cotton ball or gauze
Croatian: • Suhi jastučić vatie ili gaza
English: Pack sizes of 1, 3 or 12 pre-filled pens.
Croatian: Veličine pakiranja od 1, 3 ili 12 napunjenih brizgalica.
English: For administration of Rebif with RebiDose, the instructions provided in the package leaflet should be followed.
Croatian: Za primjenu lijeka Rebif s uređajem RebiDose treba se pridržavati uputa dobivenih u uputi o lijeku.
English: Pack size of 4 or 12 cartridges.
Croatian: Veličina pakiranja od 4 ili 12 uložaka.
English: • Blood clots in the small blood vessels may occur during your treatment.
Croatian: • Tijekom liječenja mogu se pojaviti krvni ugrušci u malim krvnim žilama.
English: (UPPER FLAP)
Croatian: (GORNJI PREKLOP)
English: Time to peak concentrations following a single subcutaneous injection were 24 to 48 hours for neopterin, beta-2-microglobulin and 2'5'OAS, 12 hours for MX1 and 24 hours for OAS1 and OAS2 gene expression.
Croatian: Vrijeme potrebno za postizanje vršne koncentracije neopterina, beta-2 mikroglobulina i 2',5'-oligoadenilat-sintetaze nakon jedne supkutane injekcije bilo je 24 do 48 sati, 12 sati za MX1 te 24 sata za ekspresiju gena OAS1 i OAS2.
English: • Muscle and joints pain
Croatian: • bol u mišićima i zglobovima
English: • The active substance is interferon beta-1a.
Croatian: • Djelatna tvar je interferon beta-1a.
English: Retinal vascular disorders (i.e. retinopathy, cotton wool spots, obstruction of retinal artery or vein)*
Croatian: Poremećaji krvnih žila mrežnice (primjerice, retinopatija, pamučaste mrlje, opstrukciju arterije ili vene mrežnice)*
English: Rebif is indicated for the treatment of relapsing multiple sclerosis.
Croatian: Rebif je indiciran za liječenje relapsnih oblika multiple skleroze.
English: Other forms of multiple sclerosis
Croatian: Drugi oblici multiple skleroze
English: The device (RebiSmart or RebiSlide) containing a pre-filled cartridge of Rebif must be stored in the device storage box in a refrigerator (2°C - 8°C).
Croatian: Uređaj (RebiSmart ili RebiSlide) koji sadrži napunjeni uložak s lijekom Rebif mora se čuvati u kutiji za čuvanje uređaja u hladnjaku (2 °C-8 °C).
English: For administration, the instructions provided in the package leaflet and in the instruction manual (Instructions for Use) provided with RebiSmart and RebiSlide should be followed.
Croatian: Za primjenu lijeka treba se pridržavati uputa u Uputi o lijeku i u priručniku za primjenu (Upute za upotrebu) koje se isporučuju uz uređaje RebiSmart i RebiSlide.
English: The proportion of patients with disability progression, as defined by at least one point increase in EDSS confirmed three months later, was reduced from 39% (placebo) to 30% (Rebif 22 micrograms).
Croatian: Udio bolesnika s napredovanjem onesposobljenosti utvrđenim povećanjem od barem jednog boda na ljestvici stanja širenja onesposobljenosti (Expanded Disability Status Scale, EDSS) potvrđenim 3 mjeseca kasnije smanjen je s 39% (placebo) na 30% (Rebif 22 mikrograma).
English: • 1st and 2nd week rd and 4
Croatian: • 1. i 2. tjedan
English: Symptoms may include muscle pain, joint pain and swelling, and rash.
Croatian: Simptomi mogu uključivati bol u mišićima i u zglobovima, oticanje i osip.
English: Pruritus, rash, erythematous rash, maculo-papular rash, alopecia*
Croatian: Pruritus, osip, eritematozni osip, makulopapularni osip, alopecija*
English: • patients with relapsing multiple sclerosis.
Croatian: • bolesnici s relapsnom multiplom sklerozom.
English: The posology for patients who have experienced a first demyelinating event is 44 micrograms of Rebif given three times per week by subcutaneous injection.
Croatian: Doziranje za bolesnike koji su doživjeli prvi događaj demijelinizacije je 44 mikrograma Rebifa tri puta tjedno supkutanom injekcijom.
English: Rebif solution for subcutaneous injection in a cartridge is intended for multidose use with either the RebiSmart electronic injection device or the RebiSlide manual pen-injector device following adequate training of the patient and/or carer.
Croatian: Otopina lijeka Rebif za supkutanu injekciju u ulošku namijenjena je za višedoznu primjenu i može se primijeniti bilo pomoću elektronskog uređaja za injiciranje RebiSmart ili ručnim uređajem s brizgalicom s injektorom RebiSlide nakon odgovarajuće obuke bolesnika i/ili njegovatelja.
English: Acetic acid for pH adjustment Sodium hydroxide for pH adjustment Water for injections
Croatian: L-metionin benzilni alkohol natrijev acetat acetatna kiselina za podešavanje pH natrijev hidroksid za podešavanje pH voda za injekcije
English: (LOWER FLAP) 6 pre-filled pens RebiDose
Croatian: (DONJI PREKLOP) 6 napunjenih brizgalica RebiDose
English: Severe elevations in transaminases
Croatian: Snažan porast transaminaza
English: Cases of nephrotic syndrome with different underlying nephropathies including collapsing focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranoproliferative glomerulonephritis (MPGN) and membranous glomerulopathy (MGN) have been reported during treatment with interferon-beta products.
Croatian: Tijekom liječenja interferonima beta zabilježeni su slučajevi nefrotskog sindroma s različitim podležećim nefropatijama uključujući kolabirajući oblik fokalne segmentalne glomeruloskleroze (FSGS), bolest minimalnih promjena (MCD), membranoproliferativni glomerulonefritis (MPGN) i membransku glomerulopatiju (MGN).
English: Mannitol, poloxamer 188, L-methionine, benzyl alcohol, sodium acetate, acetic acid and sodium hydroxide for pH adjustment and water for injections.
Croatian: Manitol, poloksamer 188, L-metionin, benzilni alkohol, natrijev acetat, acetatna kiselina i natrijev hidroksid za podešavanje pH i voda za injekcije.
English: The overall incidence of these is slightly higher with Rebif 44 than Rebif 22 micrograms.
Croatian: Ukupna incidencija ove pojave je nešto viša kod Rebif 44 mikrograma nego kod Rebif 22 mikrograma.
English: The solution for injection in a pre-filled syringe is ready for use.
Croatian: Otopina za injekciju u napunjenoj brizgalici spremna je za upotrebu.
English: • NOTE: do not use any areas in which you feel lumps, firm knots, or pain; talk to your doctor or healthcare professional about anything you find.
Croatian: • NAPOMENA: nemojte primjenjivati na područjima na kojima osjećate kvržice, tvrde čvorove ili bol: javite svom liječniku ili zdravstvenom djelatniku za takve pojave.
English: Patients with multiple sclerosis
Croatian: Bolesnici s multiplom sklerozom
English: 36 pre-filled syringes.
Croatian: 36 napunjenih štrcaljki.
English: The device containing a cartridge of Rebif must be stored in the device storage box in a refrigerator (2°C - 8°C).
Croatian: Uređaj koji sadrži uložak napunjen lijekom Rebif mora se čuvati u kutiji za čuvanje uređaja u hladnjaku (2 °C-8 °C).
English: Treatment is initiated by a gradual increase of the dose (a so-called ‘dose titration') over a period of 4 weeks in order to reduce some of the side effects, it is recommended that:
Croatian: Liječenje započinje postupnim porastom doze (takozvana „titracija doze“) tijekom razdoblja od 4 tjedna kako bi se umanjile neke od nuspojava pa se preporučuje:
English: INFORMATION IN BRAILLE rebif 44/0.5
Croatian: 16. PODACI NA BRAILLEOVOM PISMU rebif 44/0,5
English: Rebif 22 micrograms is available as a package of 1, 3, 12, or 36 syringes.
Croatian: Rebif 22 mikrograma dostupan je u pakiranju od 1, 3, 12 ili 36 štrcaljki.
English: Rebif8.8micrograms and Rebif22 micrograms are supplied in an initiation pack that is intended for use during the initial 4 weeks of treatment, during which a gradual increase in Rebif dose is recommended.
Croatian: Rebif 8,8 mikrograma i Rebif 22 mikrograma dostupni su u pakiranju za početak liječenja koje je namijenjeno za primjenu tijekom početna 4 tjedna liječenja tijekom kojih se preporučuje postupni porast doze lijeka Rebif.
English: The pack contains 6 individual doses of 0.2 mL of Rebif 8.8 micrograms solution for injection in a 1 mL type 1 glass syringe with a stainless steel needle and 6 individual doses of 0.5 mL of Rebif 22 micrograms solution for injection in a 1 mL type 1 glass syringe with a stainless steel needle.
Croatian: Pakiranje se sastoji od 6 pojedinačnih doza s 0,2 ml otopine za injekciju lijeka Rebif 8,8 mikrograma u staklenoj štrcaljki, staklo tipa I, volumena 1 ml s iglom od nehrđajućeg čelika i 6 pojedinačnih doza s 0,5 ml otopine za injekciju Rebifa 22 mikrograma u staklenoj štrcaljki, staklo tipa I, volumena 1 ml s iglom od nehrđajućeg čelika.
English: However there is some clinical data available suggesting that the safety profile in children and teenagers receiving Rebif 22 micrograms or Rebif 44 micrograms three times per week is similar to that seen in adults.
Croatian: Međutim, dostupni klinički podaci sugeriraju da je sigurnosni profil lijeka kod djece i adolescenata koji primaju Rebif 22 mikrograma ili Rebif 44 mikrograma tri puta tjedno sličan onom kod odraslih.
English: INFORMATION IN BRAILLE rebif 8.8 rebif 22
Croatian: 16. PODACI NA BRAILLEOVOM PISMU rebif 8,8 rebif 22
English: Store in a refrigerator (2°C - 8°C) away from the cooling element.
Croatian: Čuvati u hladnjaku (2 °C do 8 °C)udaljeno od rashladnih dijelova.
English: NOTE: do not use any areas in which you feel lumps, firm knots, or pain; talk to your doctor or healthcare professional about anything you find.
Croatian: NAPOMENA: nemojte primjenjivati na bilo kojem području tijela na kojem osjećate kvržice, tvrde čvorove ili bol; javite svom liječniku ili zdravstvenom djelatniku za takve pojave.
English: For the purpose of ambulatory use, you may remove Rebif from the refrigerator and store it not above 25°C for one single period of up to 14 days.
Croatian: U svrhu kućne primjene, Rebif možete izvaditi iz hladnjaka i čuvati na temperaturi do 25 °C, jednokratno u razdoblju od najdulje 14 dana.
English: RebiDose Instructions for use
Croatian: 15. UPUTE ZA UPORABU
English: Depression and suicidal ideation are known to occur in increased frequency in the multiple sclerosis population and in association with interferon use.
Croatian: Kod bolesnika s multiplom sklerozom poznata je učestalija pojava depresije i suicidnih misli kao i njihova povezanost s primjenom interferona.
English: For the purpose of ambulatory use, the patient may remove Rebif from the refrigerator and store it not above 25°C for one single period of up to 14 days.
Croatian: U svrhu kućne primjene, bolesnik može izvaditi Rebif iz hladnjaka i čuvati na temperaturi do 25 °C, jednokratno u razdoblju od najdulje 14 dana.
English: Thromboembolic events* Respiratory, thoracic and mediastinal disorders Uncommon:
Croatian: Tromboembolijski događaji* Poremećaji dišnog sustava, prsišta i sredoprsja Manje često:
English: * Million International Units, measured by cytopathic effect (CPE) bioassay against the in-house interferon beta-1a standard which is calibrated against the current international NIH standard (GB-23-902-531).
Croatian: * Milijun internacionalnih jedinica mjerenih biološkim ispitivanjem citopatskog učinka (CPE) u usporedbi sa kućnim standardom interferona beta-1a proizvođača koji je kalibriran prema trenutnom internacionalnom standardu NIH (GB-23-902-531).
English: Severe renal or hepatic failure and severe myelosuppression
Croatian: Teško zatajenje bubrega ili jetre i teška mijelosupresija
English: Rebif is available in packs of 1, 3, 12 and 36 pre-filled syringes.
Croatian: Rebif je dostupan u pakiranjima od 1, 3, 12 i 36 napunjenih štrcaljki.
English: Events were reported at various time points during treatment and may occur after several years of treatment with interferon-beta.
Croatian: Slučajevi su zabilježeni u različitim vremenskim točkama tijekom liječenja i mogu se pojaviti nakon nekoliko godina liječenja interferonom beta.
English: One mL type 1 glass syringe, with a stainless steel needle, containing 0.5 mL solution.
Croatian: Staklena štrcaljka, staklo tipa I, volumena 1 ml s iglom od nehrđajućeg čelika, koja sadrži 0,5 ml otopine.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING BOX OF 2 CARTRIDGES
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA S 2 ULOŠKA
English: • The other ingredients are mannitol, poloxamer 188, L-methionine, benzyl alcohol, sodium acetate, acetic acid, sodium hydroxide and water for injections.
Croatian: • Drugi sastojci su manitol, poloksamer 188, L-metionin, benzilni alkohol, natrijev acetat, acetatna kiselina, natrijev hidroksid i voda za injekcije.
English: • Check the expiry date on the RebiDose label or on the outer box (as indicated as “EXP”).
Croatian: • Provjerite datum isteka roka valjanosti na naljepnici brizgalice RebiDose ili na vanjskoj kutiji
English: METHOD AND ROUTE(S) OF ADMINISTRATION Subcutaneous use.
Croatian: NAČIN I PUT(EVI) PRIMJENE LIJEKA Supkutano.
English: The highest incidence of adverse reactions associated with Rebif therapy is related to flu-like syndrome.
Croatian: Najučestalija nuspojava povezana s liječenjem Rebifom odnosi se na sindrom sličan gripi.
English: This action unlocks the button.
Croatian: Tim se potezom otključava gumb.
English: Flu-like symptoms tend to be most prominent at the initiation of therapy and decrease in frequency with continued treatment.
Croatian: Simptomi slični gripi najizraženiji su na početku liječenja i postepeno se smanjuje njihova učestalost u nastavku liječenja.
English: 12 cartridges
Croatian: 12 uložaka
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING BOX OF 1, 3, 12 AND 36 SYRINGES
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA S 1, 3, 12 I 36 ŠTRCALJKI
English: 6 pre-filled syringes of Rebif 22 micrograms
Croatian: (DONJI PREKLOP) 6 napunjenih štrcaljki lijeka Rebif 22 mikrograma
English: It may cause toxic reactions and anaphylactoid reactions in infants and children up to 3 years old.
Croatian: Može uzrokovati toksične reakcije i anafilaktoidne reakcije u dojenčadi i djece do 3 godine starosti.
English: • or if you have any history of epileptic seizures, so that he/she can closely monitor your treatment and any worsening of these conditions.
Croatian: • ili ako je kod Vas dolazilo do epileptičkih napada, kako bi liječnik mogao detaljno pratiti
English: Initiation pack.
Croatian: Pakiranje za početak liječenja.
English: If you notice any of these side effects talk to your doctor.
Croatian: Ako primijetite bilo koju od navedenih nuspojava, obratite se svom liječniku.
English: Rebif is available as a solution for injection in a pre-filled syringe with a fixed needle for self-administration.
Croatian: Rebif je dostupan kao otopina za injekciju u napunjenoj štrcaljki s pričvršćenom iglom za samostalnu primjenu.
English: Where to inject Rebif
Croatian: Gdje injicirati Rebif
English: An increased formation of auto-antibodies may occur during treatment with interferon beta.
Croatian: Za vrijeme liječenja interferonom beta moguće je povećano stvaranje autoantitijela.
English: Patients who have experienced a single clinical event The usual dose is 44 micrograms (12 million IU) given three times per week.
Croatian: Bolesnici koji su iskusili pojedinačni klinički događaj Uobičajena doza je 44 mikrograma (12 milijuna IU) koja se daje tri puta tjedno.
English: This package corresponds to the patient needs for the first month of therapy.
Croatian: Ovo pakiranje odgovara bolesnikovim potrebama za prvi mjesec terapije.
English: Each pre-filled pen contains 44 micrograms,
Croatian: Svaka štrcaljka sadrži 44 mikrograma, što odgovara
English: Patients with cardiac disease, such as angina, congestive heart failure or arrhythmia, should be closely monitored for worsening of their clinical condition during initiation of therapy with interferon beta-1a.
Croatian: U početku liječenja interferonom beta-1a bolesnici sa srčanim bolestima poput angine, kongestivnog zatajenja srca ili aritmije, zahtijevaju pomno praćenje zbog mogućeg pogoršanja njihova kliničkog stanja.
English: If you use RebiSlide • Please make sure that the dose selected in the dose window of the device is 0.5 mL (which corresponds to the prescribed dose of 22 micrograms) before the injection.
Croatian: • Prije injiciranja molimo osigurajte da doza odabrana u prozorčiću uređaja odgovara 0,5 ml (koja odgovara propisanoj dozi od 22 mikrograma).
English: Single clinical event suggestive of multiple sclerosis
Croatian: Pojedini klinički događaj koji ukazuje na multiplu sklerozu
English: Pulmonary arterial hypertension has been seen at various time points during treatment,
Croatian: Plućna arterijska hipertenzija uočena je u različitim vremenskim točkama tijekom liječenja, i do nekoliko godina nakon početka liječenja s Rebif.
English: If you use RebiSlide • Please make sure that the dose selected in the dose window of the device is 0.5 mL (which corresponds to the prescribed dose of 44 micrograms) before the injection.
Croatian: • Prije injiciranja molimo osigurajte da doza odabrana u prozorčiću uređaja odgovara 0,5 ml (koja odgovara propisanoj dozi od 44 mikrograma).
English: For administration of Rebif, please read the following instructions carefully: This medicine is for single use.
Croatian: Za primjenu Rebifa, molimo pažljivo pročitajte sljedeće upute:
English: An increased risk of abortions has been reported in animal studies of other alpha and beta interferons.
Croatian: U ispitivanjima drugih alfa i beta interferona na životinjama prijavljen je povećan rizik od pobačaja.
English: Approximately 70% of patients treated with Rebif can expect to experience the typical interferon flu-like syndrome within the first six months after starting treatment.
Croatian: Tijekom prvih šest mjeseci liječenja Rebifom otprilike 70% bolesnika može očekivati pojavu tipičnog sindroma sličnog gripi specifičnih za interferon.
English: For patients initiating treatment with Rebif, Rebif 8.8 micrograms and Rebif 22 micrograms are available in a pack that corresponds to the patient needs for the first month of therapy.
Croatian: Za bolesnike koji počinju liječenje Rebifom, Rebif 8,8 mikrograma i Rebif 22 mikrograma dostupni su u pakiranju koje odgovara bolesnikovim potrebama za prvi mjesec liječenja.
English: The recommended posology of Rebif is 44 micrograms given three times per week by subcutaneous injection.
Croatian: Preporučeno doziranje za Rebif je tri puta tjedno po 44 mikrograma, supkutanom injekcijom.
English: Rebif 22 micrograms is a solution for injection in a pre-filled syringe with a fixed needle for self-administration.
Croatian: Rebif 22 mikrograma je otopina za injekciju u napunjenoj štrcaljki s pričvršćenom iglom za samostalnu primjenu.