FrancophonIA/ELRC3.0 huggingface dataset:
English: An OBR consisting of at least 2 NRTIs with or without enfuvirtide (ENF) was used in both trials.
Danish: I begge studier anvendtes et OBR, der bestod af mindst 2 NRTI'er med eller uden enfuvirtid (ENF).
English: Since darunavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of the active substance.
Danish: Da darunavir i høj grad er proteinbundet, vil dialyse højst sandsynligt ikke være effektivt til fjernelse af større mængder af det aktive stof.
English: The combination of rifapentine and boosted darunavir is not recommended.
Danish: Kombinationen af rifapentin og boostet darunavir anbefales derfor ikke.
English: Darunavir Krka contains the active substance darunavir.
Danish: Darunavir Krka indeholder det aktive stof darunavir.
English: Lopinavir/ ritonavir 800/200 mg per day N=346
Danish: Lopinavir/ ritonavir 800/200 mg pr. dag N=346
English: C-darunavir trial in healthy volunteers showed that a majority of the radioactivity in plasma after a single 400/100 mg darunavir with ritonavir dose was due to the parent active substance.
Danish: darunavir-studie med raske, frivillige forsøgspersoner viste, at størstedelen af radioaktiviteten i plasma efter en enkeltdosis darunavir med ritonavir på 400/100 mg, skyldtes det aktive moderstof.
English: The pharmacokinetic enhancing effect of pharmacokinetic enhancer other than ritonavir on darunavir was evaluated in a Phase I study in healthy subjects that were administered darunavir 800 mg with ritonavir at 100 mg or other phrmacokinetic enhancer once daily.
Danish: Den farmakokinetiske forstærkningseffekt af en anden farmakokinetisk forstærker end ritonavir på darunavir blev evalueret i et fase I-studie med raske forsøgspersoner, som fik administreret darunavir 800 mg med ritonavir 100 mg eller en anden farmakokinetisk forstærker en gang dagligt.
English: ║ based on published data with darunavir/ritonavir rosuvastatin AUC ↑ 93% rosuvastatin Cmax ↑ 277% rosuvastatin Cmin ND
Danish: baseret på offentliggjorte data med darunavir/ritonavir rosuvastatin AUC ↑ 93 % rosuvastatin Cmax ↑ 277 % rosuvastatin Cmin ND med darunavir/cobicistat 800/150 mg
English: Phenobarbital and phenytoin are expected to decrease plasma concentrations of darunavir and its pharmacoenhancer.
Danish: Phenobarbital og phenytoin forventes at nedsætte plasmakoncentrationen af darunavir og dets farmakoforstærker.
English: Serious adverse reactions are diabetes mellitus, (drug) hypersensitivity, immune reconstitution inflammatory syndrome, rash and vomiting.
Danish: Alvorlige bivirkninger er diabetes mellitus, (lægemiddel)overfølsomhed, immunrekonstitutionsinflammatorisk syndrom (IRIS), udslæt og opkastning.
English: Darunavir may increase antifungal plasma concentrations and posaconazole, isavuconazole, itraconazole, or fluconazole may increase darunavir concentrations.
Danish: Darunavir kan øge plasmakoncentrationen af antimykotika og posaconazol, isavuconazol, itraconazol eller fluconazol kan øge koncentrationen af darunavir.
English: The child must take Darunavir Krka with food.
Danish: - Barnet skal tage Darunavir Krka sammen med mad.
English: Dexamethasone may decrease plasma concentrations of darunavir.
Danish: Dexamethason kan nedsætte plasmakoncentrationen af darunavir.
English: When administration of atorvastatin and boosted darunavir is desired, it is recommended to start with an atorvastatin dose of 10 mg once daily.
Danish: Hvis der er behov for administration af atorvastatin og boostet darunavir, anbefales det at starte med en atorvastatindosis på 10 mg en gang daglig.
English: Increased AST/ALT monitoring should be considered in patients with underlying chronic hepatitis, cirrhosis, or in patients who have pre-treatment elevations of transaminases, especially during the first several months of darunavir used in combination with cobicistat or low dose ritonavir treatment.
Danish: Monitorering for forhøjet ASAT/ALAT bør overvejes hos patienter med underliggende kronisk hepatitis eller cirrose eller hos patienter, som havde forhøjede aminotransferaser før behandlingen, specielt i de første mange måneders behandling med darunavir anvendt i kombination med cobicistat eller lavdosis ritonavir.
English: Non-completer is failure imputation: patients who discontinued prematurely are imputed with a change equal to 0.
Danish: Patienter, der ikke fuldførte behandlingen, betragtes som havende behandlingssvigt, dvs. patienter der afbrød behandlingen i utide medregnes med en ændring, der tillægges størrelsen 0.
English: The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort.
Danish: Denne inducerende effekt kan vare mindst 2 uger efter seponering af perikon.
English: (CYP3A and OATP1B inhibition)
Danish: (CYP3A- og OATP1Bhæmning)
English: The exposure to total darunavir and ritonavir after intake of darunavir/ritonavir 600/100 mg twice daily and darunavir/ritonavir 800/100 mg once daily as part of an antiretroviral regimen was generally lower during pregnancy compared with postpartum.
Danish: Eksponeringen for total-darunavir og ritonavir efter indtagelse af darunavir/ritonavir 600/100 mg to gange daglig og darunavir/ritonavir 800/100 mg en gang daglig som del af et antiretroviralt regime var generelt lavere under graviditet i forhold til post partum.
English: Metabolism and nutrition disorders common anorexia, diabetes mellitus, hypercholesterolaemia, hypertriglyceridaemia, hyperlipidaemia
Danish: Metabolisme og ernæring almindelig anoreksi, diabetes mellitus, hyperkolesterolæmi, hypertriglyceridæmi, hyperlipidæmi
English: Efavirenz in combination with darunavir /ritonavir 800/100 mg once daily may result in sub-optimal darunavir Cmin.
Danish: Efavirenz i kombination med darunavir/ritonavir 800/100 mg en gang daglig kan medføre suboptimal darunavir Cmin.
English: Cmax, ng/ml AUC12h, ng.h/ml Cmin, ng/ml n=11 for AUC12h
Danish: Cmax, ng/ml AUC12t, ng∙t/ml Cmin, ng/ml n=11 for AUC12t
English: Based on theoretical considerations boosted darunavir may increase plasma concentrations of these analgesics.
Danish: Baseret på teoretiske overvejelser kan boostet darunavir øge plasmakoncentrationen af disse analgetika.
English: Co-administration of darunavir with low dose ritonavir, with active substances that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events.
Danish: Samtidig administration af darunavir med lavdosis ritonavir, og aktive stoffer, der er meget afhængige af CYP3A for eliminering, og for hvilke forhøjede plasmakoncentrationer er forbundet med alvorlige og/eller livstruende hændelser.
English: For additional clinical study results in ART-experienced adults and paediatric patients, refer to the Summary of Product Characteristics for Darunavir Krka 600 mg tablets.
Danish: Vedrørende yderligere kliniske studieresultater hos ART-erfarne voksne og pædiatriske patienter henvises til produktresumeet for Darunavir Krka 600 mg tabletter.
English: combination with another antiretroviral agent that requires pharmacoenhancement by means of co-administration with an inhibitor of CYP3A4 (see section 4.5).
Danish: kombination med et andet antiretroviralt middel, som kræver farmakoforstærkning med en CYP3A4-hæmmer (se pkt.
English: In case a dose of darunavir and/or ritonavir is missed within 6 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of darunavir and ritonavir with food as soon as possible.
Danish: Hvis en dosis darunavir og/eller ritonavir glemmes i op til 6 timer efter det tidspunkt, hvor den sædvanligvis tages, skal patienterne informeres om snarest muligt at tage den ordinerede dosis darunavir og ritonavir sammen med et måltid.
English: Systemic dexamethasone should be used with caution when combined with boosted darunavir.
Danish: Systemisk dexamethason skal bruges med forsigtighed ved kombination med boostet darunavir.
English: Boosted darunavir may increase antifungal plasma concentrations and posaconazole, isavuconazole, itraconazole or fluconazole may increase darunavir concentrations.
Danish: Boostet darunavir kan øge plasmakoncentrationen af antimykotika, og posaconazol, isavuconazol, itraconazol eller fluconazol kan øge koncentrationen af darunavir.
English: The maraviroc dose should be 150 mg twice daily when co-administered with darunavir with low dose ritonavir.
Danish: Maraviroc-dosis skal være 150 mg to gange daglig, når det administreres sammen med darunavir og lavdosis ritonavir.
English: Monitoring of renal function may be indicated when darunavir coadministered with low dose ritonavir is given in combination with tenofovir disoproxil, particularly in patients with underlying systemic or renal disease, or in patients taking nephrotoxic agents.
Danish: Monitorering af nyrefunktionen kan være indiceret, når darunavir co-administreret med lavdosis ritonavir gives i kombination med tenofovirdisoproxil, især hos patienter med underliggende systemisk eller renal sygdom eller hos patienter, der tager nefrotoksiske midler.
English: Dose for children of 3 years of age and above, weighing at least 15 kilograms who have not taken antiretroviral medicines before (your child's doctor will determine this) The doctor will work out the right once daily dose based on the weight of the child (see table below).
Danish: Dosis til børn fra 3 år og opefter med en legemsvægt på mindst 15 kg, som ikke tidligere har fået medicin mod hiv-infektion (barnets læge vil afgøre dette) Lægen vil beregne den korrekte daglige dosis på grundlag af barnets vægt (se tabellen nedenfor).
English: Study was conducted with tenofovir disoproxil fumarate 300 mg once daily.
Danish: Der blev udført et studie med tenofovirdisoproxilfumarat 300 mg x 1.
English: Alternative corticosteroids which are less dependent on CYP3A metabolism e.g. beclomethasone for intranasal or inhalational use should be considered, particularly for long term use.
Danish: Kortikosteroider, som er mindre afhængige af CYP3Ametabolisering, f.eks. nasalt eller inhaleret beclomethason bør overvejes, navnlig ved langvarig behandling.
English: Darunavir/ritonavir should not be used in children below 3 years of age because of safety concerns (see sections 4.4 and 5.3).
Danish: Darunavir/ritonavir bør ikke anvendes til børn under 3 år af sikkerhedsmæssige grunde (se pkt.
English: Digoxin 0.4 mg single dose digoxin AUC ↑ 61% digoxin Cmin ND digoxin Cmax ↑ 29% (↑ digoxin from probable inhibition of Pgp)
Danish: Digoxin 0,4 mg enkeltdosis digoxin AUC ↑ 61% digoxin Cmin ND digoxin Cmax ↑ 29% (↑ digoxin fra en sandsynlig hæmning af P-gp)
English: Darunavir co-administered with cobicistat should not be used in combination with another antiretroviral agent that requires pharmacoenhancement by means of co-administration with an inhibitor of CYP3A4 (see section 4.5).
Danish: Darunavir co-administreret med cobicistat bør ikke anvendes i kombination med et andet antiretroviralt middel, som kræver farmakoforstærkning med en CYP3A4-hæmmer (se pkt.
English: Boosted darunavir may increase the exposure to grazoprevir.
Danish: Boostet darunavir kan øge eksponeringen for grazoprevir.
English: ANTIMALARIALS Artemether/Lumefantrine 80/480 mg, 6 doses at 0, 8, 24, 36, 48, and 60 hours artemether AUC ↓ 16% artemether Cmin ↔ artemether Cmax ↓ 18% dihydroartemisinin AUC ↓ 18% dihydroartemisinin Cmin ↔ dihydroartemisinin Cmax ↓ 18% lumefantrine AUC ↑ 175% lumefantrine Cmin ↑ 126% lumefantrine Cmax ↑ 65% darunavir AUC ↔ darunavir Cmin ↓ 13% darunavir Cmax ↔
Danish: MALARIAMIDLER Artemether/lumefantrin 80/480 mg, 6 doser efter 0,8, 24, 36, 48 og 60 timer artemether AUC ↓ 16% artemether Cmin ↔ artemether Cmax ↓ 18% dihydroartemisinin AUC ↓ 18% dihydroartemisinin Cmin ↔ dihydroartemisinin Cmax ↓ 18% lumefantrin AUC ↑ 175% lumefantrin Cmin ↑ 126% lumefantrin Cmax ↑ 65% darunavir AUC ↔
English: Coadministration with boosted darunavir may cause a large increase in the concentration of these medicines.
Danish: Co-administration med boostet darunavir kan give anledning til en kraftig forøgelse af koncentrationen af disse lægemidler.
English: If this is noticed later than 6 hours after the time it is usually taken, the missed dose should not be taken and the patient should resume the usual dosing schedule.
Danish: Hvis det opdages senere end 6 timer efter det sædvanlige tidspunkt for indtagelse af en dosis, skal den glemte dosis springes over, og patienten skal fortsætte efter den sædvanlige behandlingsplan.
English: If a patient is already taking St John's wort, stop St John's wort and if possible check viral levels.
Danish: Hvis en patient allerede tager perikon, bør behandlingen med perikon seponeres, og om muligt måles det virale niveau.
English: Based on theoretical considerations darunavir co-administered with cobicistat is expected to increase metformin plasma concentrations.
Danish: Baseret på teoretiske overvejelser forventes darunavir co-administreret med cobicistat at øge plasmakoncentrationen af metformin.
English: Darunavir boosted with cobicistat is more sensitive to CYP3A induction than ritonavir-boosted darunavir: co-administration of darunavir/cobicistat with medicinal products that are strong inducers of CYP3A (e.g. St John's wort, rifampicin, carbamazepine, phenobarbital, and phenytoin) is contraindicated (see section 4.3).
Danish: Darunavir boostet med cobicistat er mere følsomt for CYP3A-induktion end darunavir boostet med ritonavir: Co-administration af darunavir/cobicistat og lægemidler, som er potente induktorer af CYP3A (f.eks. perikon, rifampicin, carbamazepin, phenobarbital og phenytoin) er kontraindiceret (se pkt.
English: Medicinal products that affect darunavir/ritonavir exposure Darunavir and ritonavir are metabolised by CYP3A.
Danish: Lægemidler, som påvirker eksponeringen af darunavir/ritonavir Darunavir og ritonavir metaboliseres via CYP3A.
English: Bosentan is expected to decrease plasma concentrations of darunavir and/or its pharmacoenhancer.
Danish: Bosentan forventes at reducere plasmakoncentrationen af darunavir og/eller dets farmakoforstærker.
English: In the virologic failures of the GS-US-216-130 trial no cross-resistance with other HIV PIs was observed.
Danish: Der blev ikke observeret krydsresistens med andre HIV-PI'er i de virologiske svigt fra GS-US-216-130-studiet.
English: If this is noticed later than 12 hours after the time it is usually taken, the missed dose should not be taken and the patient should resume the usual dosing schedule.
Danish: Hvis det opdages senere end 12 timer efter det sædvanlige tidspunkt for indtagelse af en dosis, skal den glemte dosis springes over, og patienten skal fortsætte efter den sædvanlige behandlingsplan.
English: ART-naïve paediatric patients (3 to 17 years of age and weighing at least 40 kg) The recommended dose regimen is 800 mg once daily with ritonavir 100 mg once daily taken with food.
Danish: ART-naive pædiatriske patienter (3 til 17 år og legemsvægt mindst 40 kg) Det anbefalede dosisregime er 800 mg en gang dagligt med ritonavir 100 mg en gang dagligt sammen med føde.
English: In HIV infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Danish: Immunrekonstitutionsinflammatorisk syndrom (IRIS) Hos hiv-inficerede patienter med alvorlig immundefekt på tidspunktet for påbegyndelse af antiretroviral kombinationsbehandling (CART) kan der opstå en inflammatorisk reaktion på asymptomatiske eller resterende opportunistiske infektioner.
English: Concomitant administration of boosted darunavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity.
Danish: Samtidig administration af boostet darunavir og quetiapin er kontraindiceret, da quetiapinrelateret toksicitet derved kan øges.
English: Co-administration with CYP3Ametabolised corticosteroids is not recommended unless the potential benefit to the patient outweighs the risk, in which case patients should be monitored for systemic corticosteroid effects.
Danish: Samtidig administration af CYP3A-metaboliserede kortikosteroider anbefales ikke, medmindre den potentielle fordel for patienten opvejer risikoen.
English: The use of these medicines with darunavir/cobicistat is contraindicated (see section 4.3).
Danish: Brug af disse lægemidler sammen med darunavir/cobicistat er kontraindiceret (se pkt.
English: Limited data is available in patients with HIV-1 clades other than B.
Danish: Der foreligger begrænsede data for patienter med andre hiv-1subtyper end subtype B.
English: (CYP3A induction)
Danish: (CYP3A-induktion)
English: Tablet dimension: 19.5 x 10 mm.
Danish: Tabletdimension: 19,5 × 10 mm.
English: Darunavir and ritonavir are metabolised by CYP3A.
Danish: Darunavir og ritonavir metaboliseres via CYP3A.
English: SEDATIVES/HYPNOTICS
Danish: SEDATIVA/HYPNOTIKA Buspiron
English: The clinical trial data from ART-experienced patients (TITAN trial and the pooled analysis of the POWER 1, 2 and 3 and DUET 1 and 2 trials) showed that virologic response to darunavir coadministered with low dose ritonavir was decreased when 3 or more darunavir RAMs (V11I, V32I, L33F, I47V, I50V, I54L or M, T74P, L76V, I84V and L89V) were present at baseline or when these mutations developed during treatment.
Danish: De kliniske studiedata fra ART-erfarne patienter (TITAN-studiet og den samlede analyse af studierne POWER 1, 2 og 3 samt DUET 1 og 2) viste, at det virologiske respons på darunavir, når det gives sammen med lavdosis ritonavir, blev nedsat ved tilstedeværelse af 3 eller flere darunavir-RAMs (V11I, V32I, L33F, I47V, I50V, I54L eller M, T74P, L76V, I84V og L89V) ved baseline eller ved udvikling af disse mutationer i løbet af behandlingen.
English: Clinical monitoring is recommended when co-administering darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered.
Danish: Klinisk monitorering anbefales ved co-administration af darunavir med disse sedativa/hypnotika, og en lavere dosis af sedativa/hypnotika bør overvejes.
English: Dapoxetine to treat premature ejaculation
Danish: Dapoxetin til behandling af for tidlig sædafgang
English: In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Danish: Hos nogle patienter med fremskreden hiv-infektion som tidligere har haft infektioner på grund af svækket immunforsvar (opportunistisk infektion) kan der forekomme tegn og symptomer på betændelsestilstand fra tidligere infektion kort tid efter påbegyndelse af hiv-behandling.
English: Abacavir Emtricitabine Lamivudine Stavudine Zidovudine
Danish: Abacavir Emtricitabin Lamivudin Stavudin Zidovudin
English: Non-nucleo(s/t)ide reverse transcriptase inhibitors (NNRTIs) Efavirenz
Danish: Non-nukleosid-revers-transkriptase-hæmmere (NNRTI'er) Efavirenz
English: CYP3A inducers that are contraindicated include rifampicin, St John's wort and lopinavir.
Danish: CYP3A-induktorer, som er kontraindiceret, omfatter f.eks. rifampicin, perikon og lopinavir.
English: Number of mutations from the list of mutations associated with a diminished response to darunavir/ritonavir (V11I, V32I, L33F, I47V, I50V, I54L or M, T74P, L76V, I84V or L89V)
Danish: Antal af mutationer fra listen over mutationer associeret med et formindsket respons over for darunavir (V11I, V32I, L33F, I47V, I50V, I54L eller M, T74P, L76V, I84V eller L89V) Ændring i følsomhed i forhold til reference c
English: Perphenazine Risperidone Thioridazine
Danish: Perphenazin Risperidon
English: Eye disorders uncommon conjunctival hyperaemia, dry eye rare visual disturbance
Danish: Øjne ikke almindelig konjunktival hyperæmi, tørre øjne sjælden synsforstyrrelser
English: Darunavir and ritonavir are inhibitors of CYP3A, CYP2D6 and P-gp.
Danish: Darunavir og ritonavir er hæmmere af CYP3A, CYP2D6 og P-gp.
English: Medicinal products that may be affected by darunavir boosted with ritonavir Darunavir and ritonavir are inhibitors of CYP3A, CYP2D6 and P-gp.
Danish: Lægemidler, som kan blive påvirket af darunavir boostet med ritonavir Darunavir og ritonavir metaboliseres via CYP3A, CYP2D6 og P-gp.
English: Clinical monitoring is recommended when co-administering boosted darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered.
Danish: Klinisk monitorering anbefales ved co-administration af boostet darunavir med disse sedativa/hypnotika, og en lavere dosis af sedativa/hypnotika bør overvejes.
English: The strong CYP3A inducers rifampicin and herbal preparations containing St John's wort (Hypericum perforatum).
Danish: - De potente CYP3A-induktorer rifampicin og naturlægemidler, som indeholder perikon (Hypericum perforatum).
English: PHOSPHODIESTERASE, TYPE 5 (PDE-5) INHIBITORS
Danish: PHOSPHODIESTERASE-TYPE 5 (PDE-5)-HÆMMERE Til behandling af erektil dysfunktion
English: Darunavir with low dose ritonavir may increase the exposure to grazoprevir.
Danish: Darunavir og lavdosis ritonavir kan øge eksponeringen for grazoprevir.
English: Darunavir Krka with cobicistat or ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Danish: Darunavir Krka med cobicistat eller ritonavir er ikke blevet testet med alle proteasehæmmere og må ikke bruges med andre hiv-proteasehæmmere.
English: Darunavir co-administered with low dose ritonavir must not be combined with medicinal products that are highly dependent on CYP3A for clearance and for which increased systemic exposure is associated with serious and/or life-threatening events (narrow therapeutic index) (see section 4.3).
Danish: Darunavir co-administreret med lavdosis ritonavir, må ikke kombineres med lægemidler, der er meget afhængige af CYP3A i forbindelse med clearance, og for hvilke øget systemisk eksponering er forbundet med alvorlige og/eller livstruende hændelser (snævert terapeutisk indeks).
English: Efavirenz in combination with darunavirmay result in sub-optimal darunavir Cmin.
Danish: Efavirenz i kombination med darunavir kan medføre suboptimal darunavir Cmin.
English: The increased exposure to darunavir in HIV-1 infected patients compared to healthy subjects may be explained by the higher concentrations of α1-acid glycoprotein (AAG) in HIV-1 infected patients, resulting in higher darunavir binding to plasma AAG
Danish: Den øgede eksponering for darunavir hos hiv-1-inficerede patienter sammenlignet med raske forsøgspersoner kan muligvis forklares ved de højere koncentrationer af surt α1-glykoprotein (AAG) hos hiv-1-inficerede patienter, hvilket resulterer i højere binding af darunavir til plasma-AAG og derfor i højere plasmakoncentrationer.
English: Cellulose, microcrystalline
Danish: Mikrokrystallinsk cellulose
English: HIV RNA < 50 copies/ml
Danish: hiv-RNA <50 kopier/ml
English: #, a comparable systemic exposure to sildenafil was observed for a single intake of 100 mg sildenafil alone and a single intake of 25 mg sildenafil co-administered with darunavir and low dose ritonavir.
Danish: # blev der observeret samme systemiske eksponering for sildenafil ved en enkeltdosis sildenafil på 100 mg alene og en enkeltdosis sildenafil på 25 mg administreret sammen med darunavir og lavdosis ritonavir.
English: Co-administration of boosted darunavir with clonazepam may increase concentrations of clonazepam.
Danish: Coadministration af boostet darunavir med clonazepam kan øge koncentrationen af clonazepam.
English: Ritonavir inhibits CYP3A, thereby increasing the plasma concentrations of darunavir considerably.
Danish: Ritonavir hæmmer CYP3A, hvilket øger plasmakoncentrationen af darunavir betragteligt.
English: If antidepressants are co-administered with darunavir with low dose ritonavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Danish: Hvis antidepressiva coadministreres med darunavir og lavdosis ritonavir, anbefales dosistitrering af det antidepressive lægemiddel ud fra en klinisk vurdering af antidepressivt respons.