FrancophonIA/ELRC3.0 huggingface dataset:
English: Systemic exposures to the major and minor metabolites in humans were approximately 50% and less than 1% that of azilsartan, respectively.
Croatian: Sistemska izloženost glavnom i sporednom metabolitu u ljudi iznosi približno 50%, odnosno manje od 1% izloženosti azilsartanu.
English: If you stop taking Edarbi
Croatian: Ako prestanete uzimati Edarbi
English: - If you suffer from other coexisting illnesses such as severe kidney disease or heart failure your doctor will decide on the most appropriate starting dose.
Croatian: Ako istovremeno bolujete od drugih bolesti, poput teške bolesti bubrega ili zatajenja srca, liječnik će odlučiti koja je najpogodnija početna doza za Vas.
English: Edarbi blocks this effect so that the blood vessels relax, which helps lower your blood pressure.
Croatian: Edarbi blokira taj učinak tako da se krvne žile opuštaju, što pridonosi sniženju krvnog tlaka.
English: The recommended starting dose is 40 mg once daily.
Croatian: Preporučena početna doza je 40 mg jedanput na dan.
English: Edarbi at doses of 20, 40 or 80 mg has been evaluated for safety in clinical studies in patients treated for up to 56 weeks.
Croatian: Sigurnost Edarbija u dozama 20, 40 ili 80 mg ispitana je u kliničkim ispitivanjima u bolesnika koji su bili liječeni do 56 tjedana.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Edarbi in one or more subsets of the paediatric population in hypertension (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Edarbi u jednoj ili više podskupina pedijatrijske populacije s hipertenzijom (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: A thorough QT/QTc study was conducted to assess the potential of azilsartan medoxomil to prolong the QT/QTc interval in healthy subjects.
Croatian: Provedeno je temeljito ispitivanje QT/QTc da bi se procijenio mogući učinak azilsartanmedoksomila na produljenje QT/QTc intervala u zdravih ispitanika.
English: Protein binding is constant at azilsartan plasma concentrations well above the range achieved with recommended doses.
Croatian: Vezanje za proteine je konstantno pri koncentracijama azilsartana u plazmi puno višima od raspona koji se postiže preporučenim dozama.
English: A similar effect may occur with angiotensin II receptor antagonists.
Croatian: Sličan učinak može nastati i s antagonistima receptora angiotenzina II.
English: For Edarbi, olmesartan medoxomil and valsartan, respectively dizziness was observed at an incidence of 3.0%, 3.3% and 1.8%; headache at 4.8%, 5.5% and 7.6% and dyslipidemia at 3.5%, 2.4% and 1.1%.
Croatian: Zabilježena incidencija tih nuspojava uz Edarbi, olmesartanmedoksomil i valsartan iznosila je za omaglicu 3,0%, 3,3% odnosno 1,8%; za glavobolju 4,8%, 5,5% odnosno 7,6%, a za dislipidemiju 3,5%, 2,4% odnosno 1,1%.
English: There is no evidence of a teratogenic effect, but animal studies indicated some hazardous potential to the postnatal development of the offspring such as lower body weight, a slight delay in physical development (delayed incisor eruption, pinna detachment, eye opening), and higher mortality.
Croatian: Nema dokaza da postoje teratogeni učinci, ali ispitivanja na životinjama pokazala su da postoji mogući rizik za postnatalni razvoj potomstva, kao što je niža tjelesna težina, blago usporen fizički razvoj (kasnije izbijanje sjekutića, odvajanje uški, otvaranje očiju) i povišena smrtnost.
English: Hemodialysis does not remove azilsartan from the systemic circulation.
Croatian: Hemodijalizom se azilsartan ne može ukloniti iz sistemske cirkulacije.
English: Other medicines and Edarbi Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: Small mean increases of serum uric acid were observed with Edarbi (10.8 µmol/l) compared with placebo (4.3 µmol/l).
Croatian: Opažena su mala prosječna povišenja mokraćne kiseline u serumu uz primjenu Edarbija (10,8 µmol/l) u usporedbi s placebom (4,3 µmol/l).
English: - have a disease of the adrenal gland called primary hyperaldosteronism.
Croatian: - ako imate bolest nadbubrežnih žlijezda koja se zove primarni hiperaldosteronizam.
English: In these two studies, clinically important and most common adverse events included dizziness, headache and dyslipidemia.
Croatian: U ova dva ispitivanja, klinički važne i najčešće nuspojave uključivale su omaglicu, glavobolju i dislipidemiju.
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system, angiotensin II antagonists, plain, ATC Code: C09CA09
Croatian: Farmakoterapijska skupina: lijekovi koji djeluju na renin-angiotenzinski sustav, antagonisti angiotenzina II, čisti, ATK oznaka: C09CA09
English: Edarbi may be less effective in lowering the blood pressure in black patients.
Croatian: Edarbi može biti manje djelotvoran u snižavanju krvnog tlaka u bolesnika crne rase.
English: During controlled clinical studies in healthy subjects, once daily doses up to 320 mg of azilsartan medoxomil were administered for 7 days and were well tolerated.
Croatian: Tijekom kontroliranih kliničkih ispitivanja u zdravih ispitanika, doze do 320 mg azilsartanmedoksomila bile su primijenjene jedanput na dan tijekom 7 dana i dobro su se podnosile.
English: The major metabolite in plasma is formed by Odealkylation, referred to as metabolite M-II, and the minor metabolite is formed by decarboxylation, referred to as metabolite M-I.
Croatian: Glavni metabolit u plazmi stvara se Odealkilacijom i naziva se metabolit M-II, dok se sporedni metabolit stvara dekarboksilacijom i naziva se metabolit M-I.
English: A reduction in your blood pressure will be measureable within 2 weeks of initiation of treatment and the full effect of your dose will be observed by 4 weeks.
Croatian: Sniženje krvnog tlaka moći će se izmjeriti unutar 2 tjedna od početka liječenja, a potpuni učinak vaše doze bit će vidljiv za 4 tjedna.
English: These effects, which were prevented by oral saline supplementation, do not have clinical significance in treatment of hypertension.
Croatian: Ovi učinci, koji su bili spriječeni peroralnom nadoknadom elektrolita, nemaju kliničko značenje u liječenju hipertenzije.
English: Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine po učestalosti, nuspojave su prikazane slijedom prema sve manjoj ozbiljnosti.
English: Edarbi is not recommended in early pregnancy, and must NOT be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Croatian: Edarbi se ne preporučuje u ranoj trudnoći, a NE smijete ga uzimati ako ste trudni više od 3 mjeseca, jer može prouzročiti ozbiljna oštećenja djeteta ako se uzima nakon trećeg mjeseca trudnoće.
English: - have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Croatian: - imate šećernu bolest ili oštećenu bubrežnu funkciju i liječite se lijekom za snižavanje krvnog tlaka koji sadrži aliskiren.
English: Swelling of the hands, ankles or feet is more common (in less than 1 in 10 users) when Edarbi is taken with amlodipine (a calcium channel blocker for treating hypertension) than when Edarbi is taken alone (less than 1 in 100 users).
Croatian: Oticanje šaka, gležnjeva ili stopala češće je (u manje od 1 na 10 korisnika) kad se Edarbi uzima s amlodipinom (blokator kalcijevih kanala za liječenje hipertenzije) nego kad se Edarbi uzima sam (manje od 1 na 100 korisnika).
English: No overall differences in safety and effectiveness were observed between elderly patients and younger patients, but greater sensitivity to blood pressure lowering effects in some elderly individuals cannot be ruled out (see section 4.2).
Croatian: Nisu bile opažene ukupne razlike u sigurnosti i djelotvornosti Edarbija između starijih i mlađih bolesnika, ali ne može se isključiti veća osjetljivost nekih starijih pojedinaca na učinak sniženja krvnog tlaka (vidjeti dio 4.2).
English: If you forget to take Edarbi Do not take a double dose to make up for a forgotten dose.
Croatian: Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljenu dozu.
English: Based on pharmacological considerations, the main manifestation of an overdose is likely to be symptomatic hypotension and dizziness.
Croatian: Na temelju farmakoloških razmatranja, glavni znakovi predoziranja najvjerojatnije su simptomatska hipotenzija i omaglica.
English: In addition, plasma esterases are involved in the hydrolysis of azilsartan medoxomil to azilsartan.
Croatian: Nadalje, esteraze u plazmi uključene su u hidrolizu azilsartanmedoksomila do azilsartana.
English: In vitro studies indicated that interactions based on esterase inhibition are unlikely.
Croatian: In vitro ispitivanja pokazuju da je mala vjerojatnost interakcija na temelju inhibicije esteraza.
English: OLM-M = olmesartan medoxomil, LS = least squares, LOCF = last observation carried forward * Significant difference vs.
Croatian: OLM-M = olmesartanmedoksomil, LS = najmanji kvadrati, LOCF = prijenos zadnje mjerene vrijednosti
English: After oral administration of azilsartan medoxomil, peak plasma concentrations (Cmax) of azilsartan are reached within 1.5 to 3 hours.
Croatian: Nakon peroralne primjene azilsartanmedoksomila, vršne koncentracije azilsartana u plazmi (Cmax) postižu se u roku od 1,5 do 3 sata.
English: Mannitol (E 421) Fumaric acid (E 297) Sodium hydroxide Hydroxypropylcellulose (E 463) Croscarmellose sodium Microcrystalline cellulose (E 460) Magnesium stearate (E 572)
Croatian: 6.1 Popis pomoćnih tvari manitol (E 421) fumaratna kiselina (E 297) natrijev hidroksid hidroksipropilceluloza (E 463) umrežena karmelozanatrij mikrokristalična celuloza (E 460) magnezijev stearat (E 572)
English: Following discontinuation of treatment, the majority of the elevations that had not resolved during treatment were reversible, with the creatinine levels of most subjects returning to baseline or near-baseline values.
Croatian: Nakon prekida liječenja, većina povišenja koja se nije povukla tijekom liječenja bila je reverzibilna i razine kreatinina su se u većine ispitanika vratile na početne ili gotovo početne vrijednosti.
English: 14, 28, 56 or 98 tablets; or
Croatian: 14, 28, 56 ili 98 tableta; ili
English: Pharmacokinetics of azilsartan do not differ significantly between males and females.
Croatian: Farmakokinetika azilsartana ne razlikuje se značajno između muškaraca i žena.
English: Store Edarbi in the original package in order to protect it from light and moisture.
Croatian: Čuvajte Edarbi u originalnom pakiranju radi zaštite od svjetlosti i vlage.
English: Uric acid
Croatian: Mokraćna kiselina
English: You must tell your doctor if you think you are (or might become) pregnant.
Croatian: Morate obavijestiti liječnika ako mislite da ste trudni (ili biste mogli zatrudnjeti).
English: Near-maximal antihypertensive effect is evident at 2 weeks, with maximal effects attained by 4 weeks.
Croatian: Gotovo najjači antihipertenzivni učinak postaje vidljiv nakon 2 tjedna, a najjači učinci postižu se nakon 4 tjedna.
English: In seven double blind controlled studies, a total of 5,941 patients (3,672 given Edarbi, 801 given placebo, and 1,468 given active comparator) were evaluated.
Croatian: U sedam dvostruko slijepih, kontroliranih ispitivanja ukupno je bilo procijenjeno 5941 bolesnika (3672 je dobivalo Edarbi, 801 je dobivalo placebo, a 1468 je dobivalo aktivnu kontrolu).
English: If the combination proves necessary, careful monitoring of serum lithium levels is recommended.
Croatian: Ako se ta kombinacija smatra neophodnom, preporučuje se pažljivo pratiti razine litija u serumu.
English: Manufacturer: Takeda Ireland Limited, Bray Business Park, Kilruddery, Co. Wicklow, Ireland
Croatian: Proizvođač: Takeda Ireland Limited, Bray Business Park, Kilruddery, Co.
English: Coadministration of Edarbi 40 and 80 mg with a calcium channel blocker (amlodipine) or a thiazidetype diuretic (chlortalidone) resulted in additional blood pressure reductions compared with the other antihypertensive alone.
Croatian: Istovremena primjena Edarbija u dozi od 40 ili 80 mg s blokatorima kalcijevih kanala (amlodipinom) ili tiazidnom vrstom diuretika (klortalidonom) dovela je do dodatnog sniženja krvnog tlaka u usporedbi s drugim antihipertenzivom kad se primjenjivao sam.
English: The most common adverse reaction was dizziness.
Croatian: Najčešća nuspojava bila je omaglica.
English: This generally has been true for other angiotensin II receptor (AT1) antagonists and angiotensin-converting enzyme inhibitors.
Croatian: To općenito vrijedi i za druge antagoniste receptora angiotenzina II (AT1) i inhibitore angiotenzin-konvertirajućeg enzima.
English: 14, 28, 30, 56, 90 or 98 tablets.
Croatian: 14, 28, 30, 56, 90 ili 98 tableta.
English: No dose adjustment is required in the black population, although smaller reductions in blood pressure are observed compared with a non-black population (see section 5.1).
Croatian: Nije potrebna prilagodba doze u populacije crne rase, iako su opažena sniženja krvnog tlaka manja nego u drugih populacija (vidjeti dio 5.1).
English: Adverse reactions based on pooled data (40 and 80 mg doses) are listed below according to system organ class and preferred terms.
Croatian: Nuspojave na temelju objedinjenih podataka (za doze od 40 i 80 mg) navedene su niže prema klasifikaciji organskih sustava i preporučenim izrazima.
English: C-labelled azilsartan medoxomil, approximately 55% of radioactivity was recovered in faeces and approximately 42% in urine, with 15% of the dose excreted in urine as azilsartan.
Croatian: C, približno se 55% radioaktivnosti otkrije u stolici, a približno 42% u mokraći, s time da se 15% doze izluči u mokraći kao azilsartan.
English: Angiotensin II is a substance which occurs naturally in the body and which causes the blood vessels to tighten, therefore increasing your blood pressure.
Croatian: Angiotenzin II je tvar koja se prirodno nalazi u tijelu i uzrokuje stezanje krvnih žila te tako povisuje krvni tlak.
English: Essential hypertension
Croatian: Esencijalna hipertenzija
English: Azilsartan and M-II crossed the placenta and were found in the fetuses of pregnant rats and were excreted into the milk of lactating rats.
Croatian: Azilsartan i M-II prolaze kroz posteljicu i pronađeni su u fetusima skotnih ženki štakora, te su bili izlučeni u mlijeko ženki štakora za vrijeme laktacije.
English: Takeda Pharma A/S, Dybendal Alle 10, 2630 Taastrup, Denmark
Croatian: Takeda Pharma A/S, Dybendal Alle 10, 2630 Taastrup, Danska
English: The possibility of similar effects cannot be excluded with Edarbi.
Croatian: Ne može se isključiti mogućnost da Edarbi ima slične učinke.
English: No clinically significant interactions have been reported in studies of azilsartan medoxomil or azilsartan given with amlodipine, antacids, chlortalidone, digoxin, fluconazole, glyburide, ketoconazole, metformin, and warfarin.
Croatian: U ispitivanjima nisu zabilježene klinički značajne interakcije azilsartanmedoksomila ili azilsartana kad se davao s amlodipinom, antacidima, klortalidonom, digoksinom, flukonazolom, gliburidom, ketokonazolom, metforminom i varfarinom.
English: As with other angiotensin II receptor antagonists and angiotensin converting enzyme inhibitors the antihypertensive effect was lower in black patients (usually a low-renin population).
Croatian: Kao i drugi antagonisti receptora angiotenzina II i inhibitora angiotenzinkonvertirajućeg enzima, antihipertenzivni učinak bio je slabiji u bolesnika crne rase (obično u populacije s niskim reninom).
English: The estimated absolute oral bioavailability of azilsartan medoxomil based on plasma levels of azilsartan is approximately 60%.
Croatian: Približna apsolutna bioraspoloživost azilsartanmedoksomila nakon peroralne primjene određena na temelju razina azilsartana u plazmi iznosi približno 60%.
English: Edarbi is not recommended in early pregnancy, and must NOT be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see section "Pregnancy section and breast-feeding").
Croatian: Edarbi se ne preporučuje u ranoj trudnoći, a NE smijete ga uzimati ako ste trudni više od 3 mjeseca, jer može ozbiljno naškoditi djetetu ako se uzima u tom razdoblju (vidjeti dio „Trudnoća i dojenje“).
English: No dose adjustment is required in patients with mild or moderate renal impairment.
Croatian: Nije potrebna prilagodba doze u bolesnika s blagim ili umjerenim oštećenjem funkcije bubrega.
English: Intravascular volume depletion
Croatian: Smanjen intravaskularni volumen
English: - The concomitant use of Edarbi with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73m2) (see sections 4.5 and 5.1).
Croatian: - Istodobna primjena Edarbija s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem bubrega (GFR < 60 ml/min/1,73 m2) (vidjeti dijelove 4.5 i 5.1).
English: Blood pressure reductions compared with placebo based on 24 hour mean blood pressure by ambulatory blood pressure monitoring (ABPM) and clinic blood pressure measurements at trough are shown in the table below for both studies.
Croatian: Sniženja krvnog tlaka u usporedbi s placebom na temelju 24-satnog prosječnog krvnog tlaka određenog na temelju ambulatornog praćenja krvnog tlaka (ABPM) i kliničkih mjerenja krvnog tlaka na kraju doznog intervala u oba ispitivanja prikazana su u tablici niže.
English: Key Secondary End Point:
Croatian: Ključne sekundarne mjere ishoda:
English: Administration of Edarbi for up to 5 days in subjects with mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment resulted in slight increase in azilsartan exposure (AUC increased by 1.3 to 1.6 fold, see section 4.2).
Croatian: Primjena Edarbija u trajanju do 5 dana u ispitanika s blagim (Child-Pugh A) ili umjerenim (Child-Pugh B) oštećenjem funkcije jetre dovela je do blagog povećanja izloženosti azilsartanu (AUC povećan za 1,3 do 1,6 puta, vidjeti dio 4.2).
English: Nonclinical studies demonstrated that azilsartan did not appear to affect male or female fertility in the rat (see section 5.3).
Croatian: Neklinička ispitivanja pokazala su da azilsartan nema vidljivih učinaka na plodnost u mužjaka i ženki štakora (vidjeti dio 5.3).
English: Angiotensin II is the principal pressor agent of the RAAS, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium.
Croatian: Angiotenzin II glavni je presor u RAAS-u, s učincima koji uključuju vazokonstrikciju, stimulaciju sinteze i oslobađanje aldosterona, srčanu stimulaciju i bubrežnu reapsorpciju natrija.
English: System organ class
Croatian: Klasa organskih sustava Učestalost
English: Hypovolemia should be corrected prior to administration of Edarbi, or the treatment should start under close medical supervision, and consideration can be given to a starting dose of 20 mg.
Croatian: Prije primjene Edarbija treba korigirati hipovolemiju ili liječenje treba započeti pod strogim medicinskim nadzorom te razmotriti davanje početne doze od 20 mg.
English: 14 tablets 28 tablets 30 tablets 56 tablets 90 tablets 98 tablets
Croatian: 14 tablete 28 tableta 30 tableta 56 tableta 90 tableta 98 tableta
English: - have low blood pressure or feel dizzy or lightheaded.
Croatian: - ako ste ikad imali moždani udar. - ako imate nizak krvni tlak ili osjećate omaglicu ili blagu vrtoglavicu.
English: Because no information is available regarding the use of azilsartan medoxomil during breastfeeding, Edarbi is not recommended and alternative treatments with better established safety profiles during breastfeeding are preferable, especially while breast-feeding a newborn or preterm infant.
Croatian: Budući da nema dostupnih informacija o primjeni azilsartanmedoksomila tijekom dojenja, ne preporučuje se primjena Edarbija i prednost se daje alternativnim liječenjima s ustanovljenim profilom sigurnosti primjene tijekom dojenja, osobito kad se doji novorođenče ili nedonošče.
English: These changes, also a class effect of angiotensin converting enzyme inhibitors and other angiotensin II receptor antagonists, do not appear to have clinical significance.
Croatian: Ove promjene, koji su također učinak tipičan za cijelu klasu inhibitora angiotenzin-konvertirajućeg enzima i drugih antagonista receptora angiotenzina II, čini se da nemaju nikakvo kliničko značenje.
English: In rats and dogs, increased plasma renin activity and hypertrophy/hyperplasia of the renal juxtaglomerular cells were observed.
Croatian: U štakora i pasa opažene su povećana aktivnost renina u plazmi i hipertrofija/hiperplazija jukstraglomerularnih stanica u bubrezima.
English: - The other ingredients are mannitol, fumaric acid, sodium hydroxide, hydroxypropylcellulose, croscarmellose sodium, microcrystalline cellulose, and magnesium stearate.
Croatian: - Pomoćne tvari su manitol, fumaratna kiselina, natrijev hidroksid, hidroksipropilceluloza, umrežena karmelozanatrij, mikrokristalična celuloza i magnezijev stearat.
English: - For patients such as the very elderly (75 years and above) your doctor may recommend a lower starting dose of 20 mg once a day.
Croatian: Bolesnicima, kao što su vrlo stari bolesnici (u dobi od 75 ili više godina), liječnik može preporučiti nižu početnu dozu od 20 mg jedanput na dan.
English: Blockade of the AT1 receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increases in plasma renin activity and angiotensin II circulating levels do not overcome the antihypertensive effect of azilsartan.
Croatian: Blokada receptora AT1 inhibira negativnu regulatornu povratnu spregu angiotenzina II na lučenje renina, ali posljedično pojačanje aktivnosti renina u plazmi i povišenje razine cirkulirajućeg angiotenzina II ne mogu nadvladati antihipertenzivni učinak azilsartana.
English: Dose proportionality in exposure was established for azilsartan in the azilsartan medoxomil dose range of 20 mg to 320 mg after single or multiple dosing.
Croatian: Za azilsartan ustanovljena je izloženost proporcionalna dozi u rasponu doza azilsartanmedoksomila od 20 mg do 320 mg nakon jednokratne ili višekratne primjene.
English: Edarbi is unlikely to have an effect on driving or using machines.
Croatian: Edarbi najvjerojatnije neće utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Based on in vitro studies, carboxymethylenebutenolidase is involved in the hydrolysis in the intestine and liver.
Croatian: Na temelju ispitivanja in vitro, karboksimetilenbutenolidaza uključena je u hidrolizu u crijevima i jetri.
English: Primary end point:
Croatian: Primarna mjera ishoda:
English: Monitoring of serum potassium should be undertaken as appropriate (see section 4.4).
Croatian: Kalij u serumu treba pratiti prema potrebi (vidjeti dio 4.4).
English: Additionally, Edarbi 80 mg resulted in significantly greater reductions in SBP than the highest approved doses of olmesartan medoxomil and valsartan.
Croatian: Nadalje, Edarbi u dozi od 80 mg značajno je više snizio krvni tlak nego najviša odobrena doza olmesartanmedoksomila ili valsartana.
English: Steady-state levels of azilsartan are achieved within 5 days and no accumulation in plasma occurs with repeated once-daily dosing.
Croatian: Koncentracije azilsartana u stanju dinamičke ravnoteže postižu se u roku od 5 dana, a kod ponovljenog doziranja jedanput na dan ne dolazi do nakupljanja u plazmi.
English: Furthermore, concomitant use of angiotensin II receptor antagonists and NSAIDs may lead to an increased risk of worsening of renal function and an increase in serum potassium.
Croatian: Nadalje, istovremena primjena antagonista receptora angiotenzina II i NSAIL može dovesti do povećanog rizika od pogoršanja funkcije bubrega i povećanja razine kalija u serumu.
English: Black population
Croatian: Populacija crne rase