FrancophonIA/ELRC3.0 huggingface dataset:
English: • Diseases of the blood such as leukaemia, lymphomas of any type, or other malignant neoplasms affecting the haematopoietic and lymphatic systems.
Croatian: • Bolesti krvi, kao što su leukemija, limfomi bilo kojeg tipa ili druge zloćudne novotvorine koje zahvaćaju hematopoetski i limfni sustav.
English: • If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your healthcare worker for advice before you receive this vaccine.
Croatian: • Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom zdravstvenom radniku za savjet prije nego primite ovo cjepivo.
English: This vaccine will not protect you against the other types of Ebola virus.
Croatian: Ovo cjepivo neće Vas zaštititi od drugih vrsta Ebolavirusa.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Ervebo in one or more subsets of the paediatric population in prevention of Ebola disease (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja cjepiva Ervebo u jednoj ili više podskupina pedijatrijske populacije u prevenciji ebole (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: Within each frequency grouping, adverse reactions are presented in the order of decreasing seriousness.
Croatian: Unutar svake kategorije učestalosti nuspojave su navedene u padajućem nizu prema ozbiljnosti.
English: Immunocompromised individuals may not respond as well as immunocompetent individuals to Ervebo.
Croatian: Imunokompromitirane osobe možda neće odgovoriti na Ervebo jednako dobro kao imunokompetentne osobe.
English: In the Phase 1 study with the highest rate of arthritis, 6 of 24 patients (25%) who reported arthritis after vaccination had persistent joint symptoms two years after vaccination.
Croatian: U ispitivanju faze 1 u kojem je prijavljena najviša stopa artritisa, 6 od 24 ispitanika (25%) koja su prijavila artritis nakon cijepljenja imala su trajne simptome u zglobovima dvije godine nakon cijepljenja.
English: • wheezing or trouble breathing,
Croatian: • piskanje pri disanju ili otežano disanje,
English: A progress report has to be included in the annual renewal application.
Croatian: U sklopu zahtjeva za godišnju obnovu odobrenja mora se priložiti izvješće o napretku.
English: Tell your healthcare worker if you get any of the side effects listed above.
Croatian: Obratite se svom zdravstvenom radniku ako primijetite bilo koju od gore navedenih nuspojava.
English: In some people joint pain and swelling may come back after initially going away.
Croatian: U nekih se osoba bol u zglobovima i oticanje zglobova mogu ponovno pojaviti nakon što se prvotno povuku.
English: • Ervebo is a solution for injection.
Croatian: • Ervebo je otopina za injekciju.
English: To avoid unintended exposure to livestock, ensure medical waste and other cleaning materials do not come in contact with livestock.
Croatian: Kako bi se izbjeglo nenamjerno izlaganje stoke, potrebno je pobrinuti se da stoka ne dođe u doticaj s medicinskim otpadom i drugim materijalima za čišćenje.
English: Do not use alcohol-based hand sanitiser when hands are soiled with dirt, blood, or other body fluids.
Croatian: Nemojte koristiti alkoholna sredstva za dezinfekciju ruku kad su ruke zaprljane nečistoćom, krvlju ili drugim tjelesnim tekućinama.
English: • If you have ever had an allergic reaction to a vaccine or medicine, talk to your healthcare worker before you receive this vaccine.
Croatian: • Ako ste ikada imali alergijsku reakciju na cjepivo ili lijek, obratite se svom zdravstvenom radniku prije nego što primite ovo cjepivo.
English: The preferred site is the deltoid area of the non-dominant arm or in the higher anterolateral area of the thigh.
Croatian: Poželjna mjesta primjene su u deltoidno područje na nedominantnoj ruci ili u gornji anterolateralni dio bedra.
English: Baseline seropositivity, gamma irradiation of specimens to reduce risk of wild-type Ebola virus infection of laboratory workers, and other factors may impact the immune response to vaccine, which results in a higher immune response in Protocol 012.
Croatian: Seropozitivnost na početku ispitivanja, ozračivanje uzoraka gama zrakama radi smanjenja rizika od infekcije laboratorijskih radnika divljim tipom Ebolavirusa i drugi faktori mogu utjecati na imunološki odgovor na cjepivo, što je dovelo do više stope imunološkog odgovora u Protokolu 012.
English: This trial compared Ervebo to normal saline placebo in 1,000 adults ≥18 years of age in Liberia.
Croatian: U tom se ispitivanju Ervebo uspoređivao s običnom fiziološkom otopinom kao placebom u 1000 odraslih osoba u dobi od ≥ 18 godina u Liberiji.
English: It is unknown whether concurrent administration of antiviral medication including interferons could impact vaccine virus replication and efficacy.
Croatian: Nije poznato bi li istodobna primjena antivirusnog lijeka, uključujući interferone, mogla utjecati na replikaciju virusa sadržanog u cjepivu i djelotvornost cjepiva.
English: No adverse events of infections were observed in Phase 1/2 trials.
Croatian: U ispitivanjima faze 1/2 nisu opažene infekcije kao štetni događaji.
English: The vaccine will not prevent disease caused by Filoviruses other than Zaire Ebola virus.
Croatian: Cjepivo neće spriječiti bolest uzrokovanu drugim filovirusima osim Zair Ebolavirusa.
English: In general, these reactions were reported within 7 days after vaccination, were mild to moderate in intensity, and had short duration (less than 1 week).
Croatian: Općenito su te reakcije prijavljene unutar 7 dana nakon cijepljenja, bile su blage do umjerene težine i kratko su trajale (manje od tjedan dana).
English: The bandage may be removed when there is no visible fluid leakage.
Croatian: Flaster se može ukloniti kad nema vidljivog istjecanja tekućine.
English: • a member of your family has a weak immune system.
Croatian: • ako član Vaše obitelji ima oslabljen imunološki sustav.
English: In 6 out of 18 subjects tested, the vaccine virus was detected in rashes (described as dermatitis, vesicles or cutaneous vasculitis lesions) suggesting a virally mediated process post-vaccination.
Croatian: U 6 od 18 testiranih ispitanika, virus sadržan u cjepivu pronađen je u osipima (koji su opisani kao dermatitis, vezikule ili lezije kod kutanog vaskulitisa), što ukazuje na virusom posredovan postvakcinacijski proces.
English: The median duration of arthritis across clinical trials in which arthritis was reported ranged from 2 days to 81.5 days (including duration of recurrent arthritis) with a maximum of 330 days.
Croatian: Medijan trajanja artritisa u svim kliničkim ispitivanjima u kojima je artritis prijavljen kretao se od 2 dana do 81,5 dana (uključujući trajanje rekurentnog artritisa), a maksimalno 330 dana.
English: • Safe injection practices
Croatian: • prakse sigurnog injiciranja,
English: • If you have any further questions, ask your healthcare worker.
Croatian: • Ako imate dodatnih pitanja, obratite se zdravstvenom radniku.
English: You should follow safe sex practices until you know the virus is gone from the semen.
Croatian: Potrebno je prakticirati sigurne spolne odnose dok se ne potvrdi da virus više nije prisutan u sjemenoj tekućini te osobe.
English: This vaccine might not protect everyone who receives it and the length of time you are protected from Ebola by Ervebo is not known.
Croatian: Ovo cjepivo možda neće zaštititi sve osobe koje ga prime, a trajanje zaštite od ebole nakon primjene cjepiva Ervebo nije poznato.
English: The majority of arthritis reactions were mild to moderate in severity.
Croatian: Većina slučajeva artritisa bila je blage do umjerene težine.
English: Testing for Ebola after you receive Ervebo
Croatian: Testiranje na ebolu nakon cijepljenja cjepivom Ervebo
English: • Contact with semen from a man who had Ebola.
Croatian: • doticaj sa sjemenom tekućinom muškarca koji je imao ebolu.
English: Vaccination of contacts of Ebola cases should occur as soon as possible (see section 5.1).
Croatian: Osobe koje su bile u kontaktu sa slučajevima ebole potrebno je cijepiti što je prije moguće (vidjeti dio 5.1).
English: Immune globulin (IG), blood or plasma transfusions should not be given concomitantly with Ervebo.
Croatian: Transfuzije imunoglobulina, krvi ili plazme ne smiju se davati istodobno s cjepivom Ervebo.
English: If feasible, the waste liquid from eye washes should be collected and decontaminated before discarding into the drain.
Croatian: Ako je moguće, otpadnu tekućinu koja preostane nakon ispiranja očiju potrebno je prikupiti i dekontaminirati prije izlijevanja u odvod.
English: In view of the declared Public Health Emergency of International Concern and in order to ensure early supply this medicinal product is subject to a time-limited exemption allowing reliance on batch control testing conducted in the registered site(s) that are located in a third country.
Croatian: S obzirom na proglašeni status javnozdravstvenog izvanrednog događaja od međunarodnog značaja te kako bi se osigurala rana opskrba, na ovaj se lijek primjenjuje vremenski ograničeno izuzeće kojim se dopušta oslanjanje na provjeru kakvoće serije lijeka provedenu na registriranom(im) mjestu(ima) u trećoj zemlji.
English: • Do not use this medicine after the expiry date which is stated on the vial label and the outer carton after ‘EXP'.
Croatian: • Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici bočice i kutiji iza oznake ‘EXP'.
English: When in close contact (within 1 metre) of patients with Ebola Virus Disease, healthcare workers should wear face protection (a face shield or a medical mask and goggles), a clean, non-sterile long-sleeved gown, and gloves (sterile gloves for some procedures).
Croatian: Pri bliskom kontaktu s bolesnicima koji imaju ebola virusnu bolest (unutar 1 metra) zdravstveni radnici moraju nositi zaštitu za lice (štitnik za lice ili medicinsku masku i naočale) te nositi čistu, nesterilnu kutu dugih rukava i rukavice (za neke su postupke potrebne sterilne rukavice).
English: In a biodistribution study conducted in non-human primates, vaccine virus RNA was detected in lymphoid organs up to 112 days post-vaccination.
Croatian: U ispitivanju biodistribucije provedenom na nehumanim primatima, RNK virusa sadržanog u cjepivu bio je prisutan u limfoidnim organima do 112 dana nakon cijepljenja.
English: Ervebo might make you bleed or bruise where the vaccine is injected.
Croatian: Ervebo može uzrokovati krvarenje ili nastanak modrica na mjestu gdje je cjepivo injicirano.
English: • Funeral or burial rituals that require handling the body of someone who died from Ebola.
Croatian: • pogrebne običaje ili rituale pokapanja koji iziskuju dodirivanje tijela osobe koja je preminula od ebole,
English: Ervebo should be administered by a trained healthcare worker.
Croatian: Ervebo mora primijeniti obučen zdravstveni radnik.
English: If you get Ebola, it can kill you.
Croatian: Ako se razbolite od ebole, možete umrijeti.
English: Instructions on the handling of the vaccine before administration
Croatian: Upute za rukovanje cjepivom prije primjene
English: Standard precautions, as outlined by WHO, include the following:
Croatian: Standardne mjere opreza, prema preporuci Svjetske zdravstvene organizacije (SZO), uključuju sljedeće:
English: It is also not known if it can pass to your baby through your breast milk.
Croatian: Nije poznato ni može li virus prijeći na Vaše dijete putem majčina mlijeka.
English: Do not thaw the vial in a refrigerator.
Croatian: Bočica se ne smije odmrzavati u hladnjaku.
English: Ervebo administered to female rats had no effects on development or behaviour of the offspring.
Croatian: Ervebo primijenjen ženkama štakora nije imao učinaka na razvoj ni ponašanje potomstva.
English: Clinical immunogenicity
Croatian: Klinička imunogenost
English: SOLUTION FOR INJECTION IN VIAL - PACK OF 10
Croatian: OTOPINA ZA INJEKCIJU U BOČICI - PAKIRANJE OD 10 BOČICA
English: In different trials, rash was reported with median onsets of 7.5 to 10.5 days (range from 0 to 47 days).
Croatian: U različitim ispitivanjima osip je prijavljen s medijanom vremena do nastupa od 7,5 do 10,5 dana (raspon od 0 do 47 dana).
English: • Use of PPE (to block splashes or other contact with infected materials)
Croatian: • korištenje osobne zaštitne opreme (radi zaštite od prskanja ili drugih oblika kontakta sa zaraženim materijalima),
English: Store and transport frozen at -80°C to -60°C.
Croatian: Čuvati i prevoziti zamrznuto, na temperaturi od -80°C do -60°C.
English: Administration of immune globulins, blood or plasma transfusions administered 3 months before or up to 1 month after Ervebo administration may interfere with the expected immune response.
Croatian: Transfuzija imunoglobulina, krvi ili plazme 3 mjeseca prije ili do mjesec dana nakon primjene cjepiva Ervebo može utjecati na očekivani imunološki odgovor.
English: • Ervebo should not be mixed in the same syringe with any other vaccines or medicinal products.
Croatian: • Ervebo se ne smije miješati u istoj štrcaljki ni s jednim drugim cjepivom ili lijekom.
English: As with all injectable vaccines, appropriate medical treatment and supervision should always be readily available in case of an anaphylactic event following the administration of the vaccine.
Croatian: Kao i kod svih cjepiva koja se primjenjuju injekcijom, uvijek je potrebno osigurati dostupnost odgovarajućeg medicinskog liječenja i nadzora u slučaju anafilaktičke reakcije nakon primjene cjepiva.
English: Arthritis has been reported by subjects in clinical trials at a frequency that ranged from 0% in several protocols to 23.5% in one Phase 1 study.
Croatian: Učestalost artritisa koji su prijavljivali ispitanici u kliničkim ispitivanjima kretala se od 0% u nekoliko protokola do 23,5% u jednom ispitivanju faze 1.
English: What Ervebo contains
Croatian: Što Ervebo sadrži
English: • If you have a fever (high temperature), you should talk to your healthcare worker before receiving Ervebo.
Croatian: • Ako imate vrućicu (visoku tjelesnu temperaturu), obratite se svom zdravstvenom radniku prije nego što primite Ervebo.
English: Protocols 009 and 011 used gamma irradiation of specimens to reduce risk of wild-type Ebola virus infection of laboratory workers
Croatian: Protokolima 009 i 011 uzorci su se ozračivali gama zrakama kako bi se smanjio rizik od infekcije laboratorijskih radnika divljim tipom ebolavirusa.
English: No data are available for administration via the subcutaneous or intradermal routes.
Croatian: Nema dostupnih podataka o primjeni supkutanim ili intradermalnim putem.
English: The most common injection-site adverse reactions were injection-site pain (70.3%), swelling (16.7%) and erythema (13.7%).
Croatian: Najčešće nuspojave na mjestu injiciranja bile su bol (70,3%), oticanje (16,7%) i eritem (13,7%).
English: The MAH should provide comprehensive comparability data confirming that the commercial product manufactured at the Burgwedel site is representative of the material used in the clinical trials.
Croatian: Nositelj odobrenja mora dostaviti sveobuhvatne podatke o usporedivosti koji dokazuju da je lijek namijenjen za tržište, koji se proizvodi na lokaciji Burgwedel, reprezentativan za materijal koji se koristio u kliničkim ispitivanjima.
English: This vaccine contains less than 1 mmol (23 mg) of sodium per dose.
Croatian: Ovo cjepivo sadrži manje od 1 mmol (23 mg) natrija po dozi.
English: An ERA was conducted to determine the potential impact of this vaccine on human health and the environment.
Croatian: Environmental Risk Assessment, ERA) kako bi se utvrdio mogući utjecaj ovog cjepiva na zdravlje ljudi i okoliš.
English: The vaccine should appear as a colourless to slightly brownish-yellow liquid with no particulates visible.
Croatian: Cjepivo treba izgledati kao bezbojna do blago smećkasto-žuta tekućina bez vidljivih čestica.
English: Transmission of vaccine virus through close contact with livestock is accepted as a theoretical possibility.
Croatian: Prijenos virusa sadržanog u cjepivu bliskim kontaktom sa stokom prihvaćen je kao teoretska mogućnost.
English: Following vaccination with Ervebo, individuals may test positive for Ebola glycoprotein (GP) nucleic acids, antigens, or antibodies against Ebola GP, which are targets for certain Ebola diagnostic tests.
Croatian: Nakon cijepljenja cjepivom Ervebo pojedine osobe mogu imati pozitivan nalaz testa na nukleinske kiseline glikoproteina (GP) Ebolavirusa, antigene ili protutijela na glikoprotein (GP) Ebolavirusa, koji su ciljni elementi određenih dijagnostičkih testova za ebolu.
English: • Because Ervebo does not contain the whole Ebola virus, it cannot give you Ebola virus disease.
Croatian: • Budući da cjepivo Ervebo ne sadrži cijeli Ebolavirus, od njega se ne možete razboljeti od virusne bolesti ebole.
English: The vaccine should be given with caution to individuals with thrombocytopaenia or any coagulation disorder because bleeding or bruising may occur following an intramuscular administration in these individuals.
Croatian: Cjepivo je potrebno primijeniti uz oprez osobama s trombocitopenijom ili bilo kojim poremećajem koagulacije jer u tih osoba može doći do krvarenja ili nastanka modrica nakon intramuskularne primjene.
English: Healthcare workers caring for patients with suspected or confirmed Ebola virus should apply extra infection control measures to prevent contact with the patient's blood and body fluids and contaminated surfaces or materials such as clothing and bedding.
Croatian: Zdravstveni radnici koji skrbe za bolesnike sa suspektnom ili potvrđenom infekcijom Ebolavirusom trebaju poduzeti dodatne mjere za kontrolu infekcije kako bi izbjegli doticaj s krvlju i tjelesnim tekućinama bolesnika te kontaminiranim površinama ili materijalima kao što su odjeća i posteljina.
English: The MAH should provide additional qualification data for the critical reagent used in the identity test (quality control release test for AS and FP).
Croatian: Nositelj odobrenja mora dostaviti dodatne podatke o kvalifikaciji za kritični reagens koji se koristi u testu za provjeru identiteta tvari (u sklopu kontrole kakvoće radi puštanja u promet djelatne tvari i lijeka).
English: • Store and transport frozen at -80°C to -60°C.
Croatian: • Čuvati i prevoziti zamrznuto, na temperaturi od -80°C do -60°C.
English: The marketing authorisation holder (MAH) shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi u Modulu 1.8.2
English: The MAH should develop and introduce an active substance in-process control for total protein with appropriate acceptance.
Croatian: Nositelj odobrenja mora razviti i implementirati procesnu kontrolu za ukupan sadržaj proteina u djelatnoj tvari uz odgovarajuće kriterije prihvatljivosti.
English: The safety profile of Ervebo in children and adolescents 6 to17 years of age was generally similar to that observed in adults.
Croatian: Aspekti sigurnosnog profila cjepiva Ervebo u djece i adolescenata u dobi od 6 do 17 godina općenito su bili slični onima opaženima u odraslih.
English: Standard precautions when caring for patients with known or suspected Ebola disease
Croatian: Standardne mjere opreza prilikom skrbi za bolesnike za koje se zna ili sumnja da imaju ebolu
English: • someone who has a weak immune system.
Croatian: • s osobom koja ima oslabljen imunološki sustav.
English: CI = Confidence interval; GMT = Geometric mean titer; PRNT = Plaque Reduction Neutralization Test *Protocol 011 from Month 9-12
Croatian: CI = interval pouzdanosti; GMT = geometrijska srednja vrijednost titra; PRNT = neutralizacijski test smanjenja broja plakova * Protokol 011 od 9. do 12. mjeseca.
English: Ervebo has no or negligible influence on the ability to drive and use machines.
Croatian: Ervebo ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Intramuscular use Read the package leaflet before use.
Croatian: Intramuskularno Prije uporabe pročitajte uputu o lijeku.
English: As there are no data on co-administration of Ervebo with other vaccines, the concomitant use of Ervebo with other vaccines is not recommended.
Croatian: Budući da nema podataka o istodobnoj primjeni cjepiva Ervebo s drugim cjepivima, ne preporučuje se njegova istodobna primjena s drugim cjepivima.
English: CONCLUSIONS ON THE GRANTING OF THE CONDITIONAL MARKETING AUTHORISATION PRESENTED BY THE EUROPEAN MEDICINES AGENCY
Croatian: ZAKLJUČCI EUROPSKE AGENCIJE ZA LIJEKOVE O DAVANJU UVJETNOG ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: Individuals who develop vesicular rash after receiving the vaccine should cover the vesicles until they heal to minimize the risk of possible transmission of vaccine virus through open vesicles.
Croatian: Osobe u kojih se nakon cijepljenja razvije vezikularni osip trebaju prekrivati vezikule dok ne zacijele kako bi se minimizirao rizik od mogućeg prijenosa virusa sadržanog u cjepivu putem otvorenih vezikula.
English: The MAH should complete master cell banks (MCB)/working cell bank (WCB) qualification to include also tests for specified viruses.
Croatian: Nositelj odobrenja mora upotpuniti kvalifikaciju banke matičnih stanica/banke radnih stanica tako da se uključe i testovi za specificirane viruse.
English: Joint pain and swelling may last for weeks or months in some people.
Croatian: U nekih osoba bol u zglobovima i oticanje zglobova mogu potrajati nekoliko tjedana ili mjeseci.
English: Table 1: Tabulated summary of adverse reactions considered related to vaccination MedDRA-System Organ Class Adverse Reactions
Croatian: Tablica 1: Tablični prikaz nuspojava za koje se smatra da su povezane s cijepljenjem Klasifikacija organskih sustava prema MedDRA-i
English: One dose (1 mL): Ebola Zaire Vaccine (rVSVΔG-ZEBOV-GP, live attenuated) ≥72 million pfu
Croatian: Jedna doza (1 ml): Cjepivo protiv Zair Ebolavirusa (rVSVΔG-ZEBOV-GP, živo atenuirano) ≥ 72 milijuna pfu
English: Across the Phase 1 through Phase 3 trials, 234 children and adolescents 6 to 17 years of age received a dose of Ervebo.
Croatian: U svim ispitivanjima faze 1 do faze 3, dozu cjepiva Ervebo primilo je 234 djece i adolescenata u dobi od 6 do 17 godina.
English: Implementation of EU based batch control arrangements, including the necessary variations to the terms of the marketing authorisation, has to be completed by the 31 July 2022 at the latest, in line with the agreed plan for this transfer of testing.
Croatian: Navedeno izuzeće podložno je godišnjoj ocjeni, a u svakom slučaju prestaje vrijediti 31. srpnja 2022. Implementacija dogovora o provjeri kakvoće serije lijeka unutar EU-a, uključujući potrebne izmjene uvjeta odobrenja za stavljanje u promet, mora biti izvršena najkasnije do 31. srpnja 2022., što je u skladu s dogovorenim planom za ovaj prijenos kontrolnih ispitivanja.
English: However, once thawed, the vaccine can be stored for up to 14 days at 2°C to 8°C before use.
Croatian: Međutim, nakon odmrzavanja cjepivo se prije primjene može čuvati do 14 dana na temperaturi od 2°C do 8°C.
English: Rash was characterized in a variety of ways including generalized rash (2.3%), vesicular rash (0.5%), dermatitis (0.3%), or cutaneous vasculitis (0.01%) in clinical trials.
Croatian: Osip se u kliničkim ispitivanjima opisivao na različite načine, uključujući generalizirani osip (2,3%), vezikularni osip (0,5%), dermatitis (0,3%) ili kutani vaskulitis (0,01%).
English: Ervebo administered to female rats had no effects on mating performance, fertility, or embryonic/foetal development.
Croatian: Ervebo primijenjen ženkama štakora nije imao učinaka na uspješnost parenja, plodnost ni embriofetalni razvoj.
English: The relative contributions of innate, humoral and cell-mediated immunity to protection from Zaire Ebola virus are unknown.
Croatian: Relativan doprinos prirođene, humoralne i stanično posredovane imunosti u zaštiti od Zair Ebolavirusa nije poznat.