FrancophonIA/ELRC3.0 huggingface dataset:
English: The following table from the above paediatric study shows a comparison of continuous abstinence rates (CAR) from weeks 9-12, confirmed by urine cotinine test, for the full analysis set overall study population and the 12-17 year old population.
Croatian: Tablica u nastavku iz gore navedenog pedijatrijskog ispitivanja pokazuje usporedbu stopa kontinuirane apstinencije (engl. continuous abstinence rates, CAR) od 9. do 12. tjedna, potvrđenih testom urina na kotinin, za potpuni skup podataka za analizu ukupne ispitivane populacije i populacije u dobi od 12 do 17 godina.
English: Non-psychiatric Cohort
Croatian: Nepsihijatrijska kohorta
English: In patients with a high risk of relapse, dose tapering may be considered (see section 4.4).
Croatian: U bolesnika u kojih postoji visok rizik relapsa, može se razmotriti postupno smanjivanje doze (vidjeti dio 4.4).
English: The hazard ratio for MACE was higher in patients with cardiovascular risk factors in addition to smoking compared with that in patients without cardiovascular risk factors other than smoking.
Croatian: Omjer rizika za MACE događaje bio je veći u bolesnika u kojih su uz pušenje postojali i drugi faktori kardiovaskularnog rizika u usporedbi s bolesnicima koji osim pušenja nisu imali druge faktore kardiovaskularnog rizika.
English: The table below describes the most frequently (≥ 1%) reported categories of adverse events related to psychiatric safety other than sleep disorders and disturbances.
Croatian: Tablica u nastavku pokazuje najčešće (≥ 1%) prijavljene kategorije štetnih događaja povezanih s psihijatrijskom sigurnošću osim poremećaja i smetnji sna.
English: If you have problems with your kidneys, you should speak to your doctor before taking CHAMPIX.
Croatian: Ako imate problema s bubrezima, trebate razgovarati s liječnikom prije uzimanja lijeka CHAMPIX.
English: In some cases as a result of stopping smoking, with or without CHAMPIX, an adjustment of the dose of other medicines may be necessary.
Croatian: U nekim slučajevima kao rezultat prestanka pušenja, sa ili bez lijeka CHAMPIX, može biti potrebna prilagodba doze drugih lijekova.
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with CHAMPIX should be made taking into account the benefit of breast-feeding to the child and the benefit of CHAMPIX therapy to the woman.
Croatian: Potrebno je odlučiti da li prekinuti dojenje ili prekinuti liječenje/suzdržati se od liječenja lijekom CHAMPIX uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: Maintenance of abstinence study
Croatian: Ispitivanje održavanja apstinencije
English: CHAMPIX was evaluated in a 52-week double-blind placebo-controlled study of 1,510 subjects who were not able or willing to quit smoking within four weeks, but were willing to gradually reduce their smoking over a 12 week period before quitting.
Croatian: CHAMPIX je ocijenjen u dvostruko slijepom placebom kontroliranom ispitivanju u trajanju od 52 tjedna na 1510 ispitanika koji nisu mogli ili nisu željeli prestati pušiti unutar četiri tjedna, ali su željeli postepeno smanjiti pušenje tijekom 12 tjedana prije prestanka.
English: Warnings and precautions Talk to your doctor or pharmacist before taking CHAMPIX.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku ili ljekarniku prije nego uzmete CHAMPIX.
English: Therefore, varenicline can effectively block nicotine's ability to fully activate α4β2 receptors and the mesolimbic dopamine system, the neuronal mechanism underlying reinforcement and reward experienced upon smoking.
Croatian: Stoga vareniklin može djelotvorno blokirati sposobnost nikotina da u potpunosti aktivira α4β2 receptore i mezolimbički dopaminski sustavneuronski mehanizam u podlozi poticaja i doživljaja ugode nakon pušenja.
English: Patients should then continue taking CHAMPIX for an additional 12 weeks for a total of 24 weeks of treatment (see section 5.1).
Croatian: Bolesnici zatim trebaju nastaviti uzimati CHAMPIX tijekom dodatnih 12 tjedana do ukupno 24 tjedna liječenja (vidjeti dio 5.1).
English: CHAMPIX was evaluated in a double-blind, placebo-controlled trial of 494 patients who had made a previous attempt to quit smoking with CHAMPIX, and either did not succeed in quitting or relapsed after treatment.
Croatian: CHAMPIX je procijenjen u dvostruko slijepom, placebom kontroliranom ispitivanju u kojem je sudjelovalo 494 ispitanika koji su prethodno pokušali prestati pušiti uz CHAMPIX, a nisu uspjeli prestati, ili su ponovno počeli pušiti nakon liječenja.
English: Comparative clinical studies
Croatian: Komparativna klinička ispitivanja
English: In addition, the table shows the subset of the composite NPS AE endpoint of severe intensity:
Croatian: Pored toga, tablica prikazuje podskupinu kompozitnog ishoda NPS štetnih događaja teškog intenziteta:
English: Safety and efficacy of CHAMPIX in combination with other smoking cessation therapies have not been studied.
Croatian: Nisu ispitane sigurnost i djelotvornost lijeka CHAMPIX u kombinaciji s drugim terapijama za odvikavanje od pušenja.
English: The most commonly reported adverse events in subjects treated with varenicline in this study were similar to those observed in premarketing studies.
Croatian: Najčešće prijavljeni štetni događaji u ispitanika liječenih vareniklinom u ovom ispitivanju bili su slični onima uočenim u ispitivanjima prije stavljanja lijeka u promet.
English: Additionally, a small number of MACE occurred up to 30 days after treatment (CHAMPIX 13 [0.31%]; placebo 6 [0.21%]).
Croatian: Uz to, mali broj MACE događaja javio se do 30 dana nakon liječenja (CHAMPIX 13 [0,31%]; placebo 6 [0,21%]).
English: Odds ratio in CAR 9-12 (95% CI) [p-value]
Croatian: Omjer izgleda u CAR 9-12 (95% CI) [p-vrijednost]
English: 28 Film-coated tablets 56 Film-coated tablets 112 Film-coated tablets 140 Film-coated tablets
Croatian: 28 filmom obloženih tableta 56 filmom obloženih tableta 112 filmom obloženih tableta 140 filmom obloženih tableta
English: No attempt has been made in either the design or the analysis of the CHAMPIX studies to distinguish between adverse reactions associated with study drug treatment or those possibly associated with nicotine withdrawal.
Croatian: Dizajn i analiza studija koje su ispitivale CHAMPIX nisu učinjene na način da mogu ustanoviti razliku između nuspojava uzrokovanih liječenjem ispitivanim lijekom i onih koje bi mogle biti povezane s ustezanjem od nikotina.
English: All studies were retrospective cohort studies and included patients with and without a psychiatric history.
Croatian: Sva su ispitivanja bila retrospektivna kohortna ispitivanja i uključivala su bolesnike sa ili bez psihijatrijske bolesti u anamnezi.
English: The following table shows the incidence of MACE and Hazard Ratios vs placebo for all treatment groups during treatment, and cumulative for treatment plus 30 days and through end of study.
Croatian: U tablici u nastavku prikazani su incidencija MACE i omjeri hazarda u odnosu na placebo u svim ispitivanim skupinama tijekom liječenja, kumulativno za period liječenja plus 30 dana te do kraja ispitivanja.
English: In smoking cessation therapy, risk of returning to smoking may be elevated in the period immediately following the end of treatment.
Croatian: U terapiji odvikavanja od pušenja, rizik ponovnog povratka pušenju može biti povećan u razdoblju neposredno nakon prestanka liječenja.
English: Use of CHAMPIX with other therapies for smoking cessation Consult your doctor before using CHAMPIX in combination with other smoking cessation therapies.
Croatian: Primjena lijeka CHAMPIX istodobno s drugim terapijama za prestanak pušenja Provjerite s liječnikom prije nego uzmete lijek CHAMPIX u kombinaciji s drugim terapijama za odvikavanje od pušenja.
English: CHAMPIX comes as a white tablet (0.5 mg) and a light blue tablet (1 mg).
Croatian: CHAMPIX dolazi u obliku bijelih (0,5 mg) i svijetloplavih tableta (1 mg).
English: Care should be taken with patients with a history of psychiatric illness and patients should be advised accordingly.
Croatian: Potreban je oprez u bolesnika s psihijatrijskom bolešću u anamnezi te ih se mora primjereno savjetovati.
English: The prescriber should inform the patient accordingly and discuss or consider the need for dose tapering.
Croatian: Liječnik koji propisuje lijek mora o tome obavijestiti bolesnika te s njime razmotriti i raspraviti potrebu za postupnim smanjivanjem doze.
English: Days 4 - 7:
Croatian: 4. - 7. dan:
English: Deaths and serious cardiovascular events were adjudicated by a blinded, committee.
Croatian: Smrtne slučajeve i ozbiljne kardiovaskularne događaje procijenilo je zaslijepljeno povjerenstvo.
English: What CHAMPIX contains - The active substance is varenicline.
Croatian: Što CHAMPIX sadrži - Djelatna tvar je vareniklin.
English: There have been some reports of increased intoxicating effects of alcohol in patients taking CHAMPIX.
Croatian: Postoje izvješća o povećanim toksičnim učincima alkohola u bolesnika koji uzimaju CHAMPIX.
English: Although it was not studied, CHAMPIX may pass into breast milk.
Croatian: Iako to nije ispitano, postoji mogućnost da se CHAMPIX izlučuje u majčino mlijeko.
English: If you forget to take CHAMPIX
Croatian: Ako ste zaboravili uzeti CHAMPIX
English: The prespecified statistical testing procedures stopped testing after the high-dose varenicline vs Placebo treatment comparison in the overall study did not achieve statistical significance.
Croatian: Testiranje je zaustavljeno prethodno određenim statističkim postupcima testiranja nakon što usporedba liječenja visokom dozom vareniklina naspram placeba u ukupnom ispitivanju nije postigla statistički značaj.
English: A population-based cohort study compared infants exposed to CHAMPIX in utero (N=335) with infants born to mothers who smoked during pregnancy (N=78,412) and infants born to non-smoking mothers (N=806,438).
Croatian: Kohortno ispitivanje temeljeno na populaciji uspoređivalo je dojenčad koja je bila izložena lijeku CHAMPIX in utero (N=335) s dojenčadi čije su majke pušile tijekom trudnoće (N=78 412) i dojenčadi od majki nepušača (N=806 438).
English: In male rats dosed for 2 years with varenicline, there was a dose-related increase in the incidence of hibernoma (tumour of the brown fat).
Croatian: U mužjaka štakora koji su 2 godine primali doze vareniklina zabilježena je povećana incidencija hibernoma (tumora smeđega masnog tkiva), povezana s dozom.
English: Pooled data from these 18 trials showed a similar incidence rate of individual categories of psychiatric events in patients treated with varenicline compared to patients treated with placebo.
Croatian: Objedinjeni podaci iz tih 18 kliničkih ispitivanja pokazali su sličnu stopu incidencije pojedinačnih kategorija psihijatrijskih događaja u bolesnika liječenih vareniklinom u usporedbi s bolesnicima koji su primali placebo.
English: CHAMPIX dosing should usually start 1-2 weeks before this date (see section 5.1).
Croatian: S uzimanjem lijeka CHAMPIX obično treba započeti 1-2 tjedna prije toga datuma (vidjeti dio 5.1).
English: The effects of changes in your body resulting from stopping smoking, with or without treatment with CHAMPIX, may alter the way other medicines work.
Croatian: Učinci promjena u tijelu koje nastaju kao posljedica prestanka pušenja, uz liječenje lijekom CHAMPIX ili bez njega, mogu promijeniti način djelovanja drugih lijekova.
English: The use of CHAMPIX, bupropion, and NRT was not associated with an increased risk of CV AEs in smokers treated for up to 12 weeks and followed for up to 1 year compared to placebo, although because of the relatively low number of events overall, an association cannot be entirely ruled out.
Croatian: Primjena lijeka CHAMPIX, bupropiona i NRT ne povezuje se s povećanim rizikom od KV štetnih događaja u pušača liječenih do najviše 12 tjedana i praćenih do 1 godinu u usporedbi s placebom, premda se povezanost zbog relativno malog ukupnog broja događaja ne može u potpunosti isključiti.
English: Overall n/N (%)
Croatian: Ukupno n/N (%)
English: In the majority of cases nausea occurred early in the treatment period, was mild to moderate in severity and seldom resulted in discontinuation.
Croatian: U većini se slučajeva mučnina javila u ranoj fazi liječenja, bila je blaga do umjerena, a rijetko je dovela do prekida liječenja.
English: Non-clinical data revealed no hazard for humans based on standard male and female fertility studies in the rat (see section 5.3).
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju standardnih ispitivanja plodnosti u mužjaka i ženki štakora (vidjeti dio 5.3).
English: CA = continuous abstinence rate; CI = confidence interval; NRT=Nicotine replacement therapy patch
Croatian: CA (engl. continuous abstinence) = stopa neprekidne apstinencije; CI = interval pouzdanosti; NRT= flaster nikotinske zamjenske terapije
English: Co-administration of cimetidine, with varenicline increased the systemic exposure of varenicline by 29% due to a reduction in varenicline renal clearance.
Croatian: Istodobna primjena cimetidina s vareniklinom povećala je sistemsku izloženost vareniklinu za 29% zbog smanjenja bubrežnog klirensa vareniklina.
English: Effect of smoking cessation
Croatian: Učinci prestanka pušenja
English: In circulation, varenicline comprises 91% of drug-related material.
Croatian: Vareniklin u izvornom obliku predstavlja 91% tvari povezanih s lijekom u cirkulaciji.
English: In clinical trials and post-marketing experience there have been reports of seizures in patients with or without a history of seizures, treated with CHAMPIX.
Croatian: U kliničkim ispitivanjima i iskustvima nakon što je lijek stavljen na tržište, prijavljeni su napadaji u bolesnika s ili bez napadaja u anamnezi, a koji su liječeni lijekom CHAMPIX.
English: Deaths and cardiovascular events were adjudicated by a blinded, independent committee.
Croatian: Smrti i kardiovaskularne događaje procjenjivalo je zaslijepljeno, neovisno povjerenstvo.
English: The results showed a similar incidence of combined neuropsychiatric adverse events, other than sleep disorders, in patients treated with varenicline compared to patients treated with placebo, with a risk ratio (RR) of 1.01 (95% CI: 0.89-1.15).
Croatian: Rezultati su pokazivali sličnu incidenciju kombiniranih neuropsihijatrijskih štetnih događaja, osim poremećaja sna, u bolesnika liječenih vareniklinom u usporedbi s bolesnicima koji su uzimali placebo, uz omjer rizika (RR) od 1,01 (95% CI: 0,89-1,15).
English: CHAMPIX can also reduce the enjoyment of cigarettes if you do smoke when on treatment.
Croatian: CHAMPIX može umanjiti užitak pušenja cigareta ako ipak pušite tijekom liječenja.
English: OTHER sun as symbol moon as symbol
Croatian: simbol sunca simbol mjeseca
English: Use with other therapies for smoking cessation
Croatian: Primjena u kombinaciji s drugim terapijama za prestanak pušenja
English: If serious neuropsychiatric symptoms occur whilst on varenicline treatment, patients should discontinue varenicline immediately and contact a healthcare professional for re-evaluation of treatment.
Croatian: Ako se tijekom liječenja vareniklinom pojave ozbiljni neuropsihijatrijski simptomi, bolesnici ga moraju odmah prestati uzimati te se trebaju obratiti zdravstvenom radniku radi ponovne procjene liječenja.
English: CHAMPIX can help to relieve the craving and withdrawal symptoms associated with stopping smoking.
Croatian: CHAMPIX može pomoći ublažiti žudnju i simptome ustezanja povezane s prestankom pušenja.
English: Does not contain a tablet
Croatian: Ne sadrži nikakve tablete.
English: Observational Studies
Croatian: Opservacijska ispitivanja
English: Study 1 (n=1022)
Croatian: Ispitivanje 1 (n=1022)
English: If you are taking CHAMPIX and develop agitation, depressed mood, changes in behaviour that are of concern to you or your family or if you develop suicidal thoughts or behaviours you should stop taking CHAMPIX and contact your doctor immediately for treatment assessment.
Croatian: Ako uzimate CHAMPIX i postanete uznemireni ili depresivni, ako primijetite promjene u ponašanju koje zabrinjavaju Vas, Vašu obitelj ili liječnika, odnosno ako Vam se jave misli o samoubojstvu ili samoubilačko ponašanje, odmah prestanite uzimati CHAMPIX i obratite se svom liječniku zbog procjene liječenja.
English: R-Pharm Germany GmbH Heinrich-Mack-Str. 35, 89257 Illertissen Germany or
Croatian: R-Pharm Germany GmbH Heinrich-Mack-Str. 35, 89257 Illertissen Njemačka ili
English: If you stop taking CHAMPIX
Croatian: Ako prestanete uzimati CHAMPIX
English: Following administration of multiple oral doses to healthy volunteers, steady-state conditions were reached within 4 days.
Croatian: Nakon primjene višestrukih peroralnih doza u zdravih ispitanika stanje dinamičke ravnoteže uspostavljeno je unutar 4 dana.
English: Animal studies suggest that varenicline is excreted in breast milk.
Croatian: Istraživanja na životinjama ukazuju na to da se vareniklin izlučuje u mlijeko životinja.
English: Analyses of clinical trial data did not show evidence of an increased risk of serious neuropsychiatric events with varenicline compared to placebo.
Croatian: Analize podataka iz kliničkih ispitivanja nisu pružile dokaze o povećanom riziku od ozbiljnih neuropsihijatrijskih događaja tijekom uzimanja vareniklina u usporedbi s placebom.
English: When 0.5 mg twice daily was given, steady-state daily exposure of varenicline was, on average, higher (by approximately 40%) in adolescent patients with bodyweight ≤ 55 kg compared to that noted in the adult population.
Croatian: Kad je primijenjena doza od 0,5 mg dvaput na dan, dnevna izloženost vareniklinu u stanju dinamičke ravnoteže u prosjeku je bila viša (za otprilike 40%) u adolescenata tjelesne težine ≤ 55 kg u usporedbi s onom zabilježenom u odrasloj populaciji.
English: In the table below all adverse reactions, which occurred at an incidence greater than placebo are listed by system organ class and frequency (very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100) and rare (≥ 1/10,000 to < 1/1,000)).
Croatian: U sljedećoj su tablici sve nuspojave čija je incidencija bila veća kod primjene vareniklina nego kod primjene placeba navedene po organskim sustavima i učestalosti (vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100) i rijetko (≥ 1/10 000 i < 1/1000)).
English: For elderly patients with reduced renal function please refer to section 4.2.
Croatian: Za starije bolesnike sa smanjenom funkcijom bubrega vidjeti dio 4.2.
English: Varenicline has been shown to be dialyzed in patients with end stage renal disease (see section 5.2), however, there is no experience in dialysis following overdose.
Croatian: Pokazalo se da se vareniklin može odstraniti dijalizom u bolesnika u krajnjoj fazi bubrežne bolesti (vidjeti dio 5.2), ali nema iskustva s dijalizom nakon predoziranja.
English: A meta-analysis of 15 clinical trials of ≥ 12 weeks treatment duration, including 7002 patients (4190 CHAMPIX, 2812 placebo), was conducted to systematically assess the cardiovascular safety of CHAMPIX.
Croatian: Provedena je metaanaliza podataka iz 15 kliničkih ispitivanja koja su trajala ≥ 12 tjedana i obuhvatila 7002 bolesnika (4190 bolesnika primala su CHAMPIX, a 2812 placebo), kako bi se sustavno procijenila kardiovaskularna sigurnost primjene lijeka CHAMPIX.
English: After 12 weeks of treatment, if you have stopped smoking, your doctor may recommend an additional 12 weeks of treatment with CHAMPIX 1 mg film-coated tablets twice daily to help avoid returning back to smoking.
Croatian: Ako nakon 12 tjedana liječenja prestanete pušiti, liječnik će Vam možda preporučiti dodatnih 12 tjedana liječenja lijekom CHAMPIX 1 mg filmom obloženim tabletama dvaput na dan radi sprječavanja ponovnog pušenja.
English: Patients included in this study had taken CHAMPIX for a smoking-cessation attempt in the past (for a total treatment duration of a minimum of two weeks), at least three months prior to study entry, and had been smoking for at least four weeks.
Croatian: Bolesnici uključeni u ovo ispitivanje uzimali su CHAMPIX kao pokušaj prestanka pušenja u prošlosti (liječenje je ukupno trajalo najmanje dva tjedna), najmanje tri mjeseca prije uključenja u ispitivanje, a pušili su najmanje četiri tjedna.
English: There were more events reported in patients in the psychiatric cohort in each treatment group compared with the non-psychiatric cohort, and the incidence of events in the composite endpoint was higher for each of the active treatments compared to placebo.
Croatian: Više je događaja zabilježeno u bolesnika u psihijatrijskoj kohorti u svakoj liječenoj skupini u usporedbi s nepsihijatrijskom kohortom i incidencija događaja u kompozitnom ishodu bila je viša za svako liječenje djelatnom tvari u usporedbi s placebom.
English: CHAMPIX is indicated for smoking cessation in adults.
Croatian: CHAMPIX je indiciran za odvikavanje od pušenja u odraslih.
English: Some of the patients requiring coronary revascularisation underwent the procedure as part of management of nonfatal MI and hospitalisation for angina.
Croatian: Neki bolesnici kojima je bila potrebna koronarna revaskularizacija bili su podvrgnuti tom zahvatu u sklopu liječenja infarkta miokarda bez smrtnog ishoda i hospitalizacije zbog angine pektoris.
English: R-Pharm Germany GmbH Heinrich-Mack-Str. 35, 89257 Illertissen Germany
Croatian: R-Pharm Germany GmbH Heinrich-Mack-Str. 35, 89257 Illertissen Njemačka
English: For patients with moderate renal impairment who experience adverse reactions that are not tolerable, dosing may be reduced to 1 mg once daily.
Croatian: U bolesnika s umjerenim oštećenjem bubrega u kojih se jave nuspojave koje se ne mogu podnijeti, doza se može smanjiti na 1 mg jedanput na dan.
English: Varenicline exhibits linear kinetics when given as single (0.1 to 3 mg) or repeated 1 to 3 mg/day doses.
Croatian: Kinetika vareniklina je linearna kada se lijek primjenjuje u jednoj dozi (0,1 do 3 mg) ili ponovljenim (1 do 3 mg na dan) dozama.
English: The efficacy of CHAMPIX in smoking cessation is a result of varenicline's partial agonist activity at the α4β2 nicotinic receptor where its binding produces an effect sufficient to alleviate symptoms of craving and withdrawal (agonist activity), while simultaneously resulting in a reduction of the rewarding and reinforcing effects of smoking by preventing nicotine binding to α4β2 receptors (antagonist activity).
Croatian: Djelotvornost lijeka CHAMPIX u odvikavanju od pušenja rezultat je djelomično agonističkog djelovanja vareniklina na α4β2 nikotinski receptor, gdje njegovo vezivanje proizvodi učinak koji je dostatan za ublažavanje simptoma žudnje i ustezanja (agonističko djelovanje), dok istodobno umanjuje učinke koji potiču na pušenje i izazivaju osjećaj ugode tako što sprječava vezivanje nikotina za α4β2 receptore (antagonističko djelovanje).
English: Following two-week titration, patients randomised to varenicline with a body weight >55 kg received 1 mg twice daily (high dose group) or 0.5 mg twice daily (low dose group), while patients with a body weight ≤55 kg received 0.5 mg twice daily (high dose group) or 0.5 mg once daily (low dose group).
Croatian: Nakon dvotjedne titracije bolesnici randomizirani kako bi primili vareniklin s tjelesnom težinom > 55 kg primali su 1 mg dvaput na dan (skupina koja je primala visoku dozu) ili 0,5 mg dvaput na dan (skupina koja je primala nisku dozu), dok su bolesnici s tjelesnom težinom ≤ 55 kg primali 0,5 mg dvaput na dan (skupina koja je primala visoku dozu) ili 0,5 mg jedanput na dan (skupina koja je primala nisku dozu).
English: Electrophysiology studies in vitro and neurochemical studies in vivo have shown that varenicline binds to the α4β2 neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity, but at a significantly lower level than nicotine.
Croatian: Elektrofiziološka ispitivanja in vitro i neurokemijska ispitivanja in vivo pokazala su da se vareniklin veže na α4β2 neuronske nikotinske acetilkolinske receptore i stimulira aktivnost koju posreduju receptori, ali u značajno manjem stupnju od nikotina.