FrancophonIA/ELRC3.0 huggingface dataset:
English: If you forget to take Sprimeo
Slovenian: Če ste pozabili vzeti zdravilo Sprimeo
English: The MAH shall submit the final results and study report for the active treatment phase of the ALTITUDE study when available
Slovenian: Imetnik dovoljenja za promet z zdravilom bo predložil končne rezultate in poročilo o aktivni fazi študije ALTITUDE, ko bodo na voljo.
English: Laboratory findings
Slovenian: Laboratorijski izvidi
English: These observed changes, however, did not correlate with the severity of renal impairment.
Slovenian: Te spremembe, ki so jih opažali, pa niso bile sorazmerne s stopnjo okvare ledvic.
English: CYP450 interactions
Slovenian: Medsebojno delovanje s CYP450
English: You may need to stop Sprimeo.
Slovenian: Morda boste morali prenehati z jemanjem zdravila Sprimeo.
English: The MAH shall submit an updated risk management plan (RMP) that adequately describes all the safety concerns, the pharmacovigilance activities and the interventions designed to identify, characterise, prevent or minimise the risks.
Slovenian: Imetnik dovoljenja za promet z zdravilom bo predložil posodobljen načrt za obvladovanje tveganja (RMP), ki bo ustrezno opisoval vse, kar zadeva varnost, farmakovigilančne aktivnosti in ukrepe, z namenom ugotavljanja, karakterizacije, preprečevanja ali zmanjševanja tveganja.
English: In addition, measures necessary to maintain patent airways should be provided.
Slovenian: Poleg tega je treba izvajati vse potrebne ukrepe za vzdrževanje odprtih dihalnih poti.
English: However, CYP3A4 inhibitors often also affect Pgp.
Slovenian: Vendar zaviralci CYP3A4 pogosto vplivajo tudi na P-gp.
English: Aliskiren is mainly eliminated as unchanged compound in the faeces (78%).
Slovenian: Aliskiren se večinoma izloča z blatom v nespremenjeni obliki (78 %).
English: Your doctor may prescribe Sprimeo together with other medicines used to treat high blood pressure.
Slovenian: Zdravnik vam lahko predpiše zdravilo Sprimeo skupaj z drugimi zdravili za zdravljenje visokega krvnega tlaka.
English: Sprimeo has been evaluated for safety in more than 7,800 patients, including over 2,300 treated for over 6 months, and more than 1,200 for over 1 year.
Slovenian: Varnost zdravila Sprimeo so ocenjevali pri več kot 7.800 bolnikih, med drugim pri več kot 2.300 bolnikih, ki so bili zdravljeni več kot 6 mesecev, in pri več kot 1.200 bolnikih, ki so bili zdravljeni več kot 1 leto.
English: Lowering the blood pressure to a normal level reduces the risk of developing these disorders.
Slovenian: Zniževanje krvnega tlaka na normalne vrednosti zmanjšuje tveganje, da bi prišlo do navedenih bolezni.
English: A possible mechanism is saturation of transporters at the absorption site or at the hepatobiliary clearance route.
Slovenian: Možen mehanizem je lahko nasičenost prenašalcev na mestu absorpcije ali pri izločanju preko hepatobiliarnega sistema.
English: Aliskiren plasma protein binding is moderate (47-51%) and independent of the concentration.
Slovenian: Aliskiren se zmerno veže na proteine v plazmi (47 - 51 %) in sicer neodvisno od koncentracije.
English: Aliskiren does not inhibit the CYP450 isoenzymes (CYP1A2, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A).
Slovenian: Aliskiren ne zavira izoencimov CYP450 (CYP1A2, 2C8, 2C9, 2C19, 2D6, 2E1 in 3A).
English: It is not known whether aliskiren is excreted in human milk.
Slovenian: Ni znano, ali se aliskiren izloča v materino mleko pri človeku.
English: The antihypertensive effect is substantially present within two weeks (85-90%) after initiating therapy with 150 mg once daily.
Slovenian: Antihipertenzivni učinek se v precejšnji meri izrazi v dveh tednih (85 - 90 %) po začetku zdravljenja z odmerkom 150 mg enkrat dnevno.
English: Hereditary or idiopathic angioedema.
Slovenian: Dedni ali idiopatski angioedem.
English: Meals with a high fat content reduce Cmax by 85% and AUC by 70%.
Slovenian: Obroki z veliko vsebnostjo maščob zmanjšajo Cmax za 85 % in AUC za 70 %.
English: If angioedema occurs, Sprimeo should be promptly discontinued and appropriate therapy and monitoring provided until complete and sustained resolution of signs and symptoms has occurred.
Slovenian: Če pride do angioedema, je treba zdravljenje z zdravilom Sprimeo takoj prekiniti in poskrbeti za ustrezno zdravljenje in spremljanje bolnika, dokler znaki in simptomi niso v celoti in trajno odpravljeni.
English: In the event that any signs of renal failure occur, aliskiren should be promptly discontinued.
Slovenian: V primeru, da pride do kakršnihkoli znakov odpovedi ledvic, je treba jemanje aliskirena nemudoma prekiniti.
English: In some cases this occurred as part of a hypersensitivity reaction.
Slovenian: V nekaterih primerih se je artralgija pojavila v sklopu preobčutljivostne reakcije.
English: Sprimeo should be taken with a light meal once a day, preferably at the same time each day.
Slovenian: Zdravilo Sprimeo je treba jemati z lahkim obrokom enkrat na dan, najbolje vsak dan ob istem času.
English: Sprimeo has been studied in 1,864 patients aged 65 years or older, and in 426 patients aged 75 years or older.
Slovenian: Zdravilo Sprimeo so proučevali pri 1.864 bolnikih, starih 65 let ali več, in pri 426 bolnikih, starih 75 let ali več.
English: The usual dose of Sprimeo for patients aged 65 years or older is 150 mg.
Slovenian: Običajen odmerek zdravila Sprimeo za bolnike stare 65 let ali več, je 150 mg.
English: The adverse drug reactions (Table 1) are ranked under heading of frequency, the most frequent first, using the following convention: very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1,000, <1/100); rare (≥1/10,000, <1/1,000); very rare (<1/10,000) and not known (cannot be estimated from the available data).
Slovenian: Neželeni učinki (preglednica 1) so razvrščeni po skupinah glede na pogostnost, najpogostejši najprej, po naslednjem dogovoru: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: If any of these apply to you, tell your doctor before you take Sprimeo.
Slovenian: Če kaj od navedenega velja za vas, povejte zdravniku, preden začnete jemati zdravilo Sprimeo.
English: Beneficial effects of Sprimeo on mortality and cardiovascular morbidity and target organ damage are currently unknown.
Slovenian: Ugodni vplivi zdravila Sprimeo na umrljivost, kardiovaskularno obolevnost in prizadetost tarčnih organov trenutno niso znani.
English: In experimental animals, it has been shown that P-gp is a major determinant of Sprimeo bioavailability.
Slovenian: Na poskusnih živalih se je pokazalo, da je P-gp glavna determinanta biološke uporabnosti zdravila Sprimeo.
English: Aliskiren does not induce CYP3A4.
Slovenian: Aliskiren ne inducira CYP3A4.
English: If this continues for a long time, it can damage the blood vessels of the brain, heart and kidneys, and may result in a stroke, heart failure, heart attack or kidney failure.
Slovenian: Če to traja dolgo, lahko poškoduje krvne žile v možganih, srcu in ledvicah in lahko povzroči možgansko kap, srčno popuščanje, srčni infarkt ali odpoved ledvic.
English: If symptomatic hypotension should occur, supportive treatment should be initiated.
Slovenian: Če pride do simptomatske hipotenzije, je treba uvesti podporno zdravljenje.
English: Therefore aliskiren is not expected to affect the systemic exposure of substances that inhibit, induce or are metabolised by these enzymes.
Slovenian: Zato ni pričakovati, da bi aliskiren vplival na sistemsko izpostavljenost snovem, ki zavirajo ali inducirajo te encime oziroma so njihovi substrati.
English: 4.8 Undesirable effects
Slovenian: 4.8 Neţeleni učinki
English: The MAH must ensure that the system of pharmacovigilance, presented in Module 1.8.1 of the Marketing Authorisation, is in place and functioning before and whilst the medicinal product is on the market.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da je sistem farmakovigilance, predložen v modulu 1.8.1 dovoljenja za promet z zdravilom, vzpostavljen in deluje, preden da zdravilo v promet in ves čas trženja zdravila.
English: Food intake Meals with a high fat content have been shown to reduce the absorption of Sprimeo substantially.
Slovenian: Uživanje hrane Pokazalo se je, da obroki z veliko vsebnostjo maščob bistveno zmanjšajo absorpcijo zdravila Sprimeo.
English: The potential for drug interactions at the P-gp site will likely depend on the degree of inhibition of this transporter.
Slovenian: Možnost interakcij na mestu P-gp je verjetno odvisna od stopnje zaviranja tega prenašalca.
English: Do not use Sprimeo after the expiry date which is stated on the carton and blister.
Slovenian: Zdravila Sprimeo ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu.
English: In patients whose blood pressure is not adequately controlled, the dose may be increased to 300 mg once daily.
Slovenian: Pri bolnikih, katerih krvni tlak ni urejen v zadostni meri, je mogoče odmerek zvišati na 300 mg enkrat dnevno.
English: Following intravenous administration, the mean volume of distribution at steady state is approximately 135 litres, indicating that aliskiren distributes extensively into the extravascular space.
Slovenian: Po intravenski aplikaciji je povprečen volumen porazdelitve v stanju dinamičnega ravnovesja približno 135 litrov, kar nakazuje, da se aliskiren v veliki meri porazdeli po ekstravaskularnem prostoru.
English: Pharmacotherapeutic group: Renin inhibitor, ATC code: C09XA02
Slovenian: Farmakoterapevtska skupina: zaviralec renina, oznaka ATC: C09XA02
English: Depending on how you respond to the treatment your doctor may prescribe a higher dose of one 300 mg tablet once daily.
Slovenian: Odvisno od vašega odziva na zdravljenje vam bo zdravnik morda predpisal višji odmerek, to je eno 300-miligramsko tableto na dan.
English: Therefore dialysis is not adequate to treat aliskiren over-exposure.
Slovenian: Dializa torej ne zadošča za odpravljanje prevelike izpostavljenosti aliskirenu.
English: Safety pharmacology studies did not reveal any adverse effects on central nervous, respiratory or cardiovascular function.
Slovenian: Farmakološke študije varnosti niso razkrile nobenega neželenega učinka na centralno živčevje, dihanje in delovanje srčnožilnega sistema.
English: Sprimeo helps to lower high blood pressure.
Slovenian: Sprimeo pomaga zniževati visok krvni tlak.
English: Hence, interactions due to inhibition or induction of CYP450 isoenzymes are not expected.
Slovenian: Zato ni pričakovati interakcij zaradi zaviranja ali indukcije izoencimov CYP450.
English: Carcinogenic potential was assessed in a 2-year rat study and a 6-month transgenic mouse study.
Slovenian: Karcinogeni potencial so ocenjevali v 2-letni študiji na podganah in v 6-mesečni študiji na transgenskih miših: karcinogenega potenciala niso zasledili.
English: 4.7 Effects on ability to drive and use machines
Slovenian: 4.7 Vpliv na sposobnost voţnje in upravljanja s stroji
English: The increase may be higher with higher aliskiren doses.
Slovenian: Zvišanje je lahko še večje pri večjih odmerkih aliskirena.
English: Although this has not been investigated for aliskiren, it is known that P-gp also controls tissue uptake of a variety of substrates and P-gp inhibitors can increase the tissue-to-plasma concentration ratios.
Slovenian: Čeprav tega niso proučevali pri aliskirenu, je znano, da P-gp tudi uravnava privzem različnih snovi v tkiva in da zaviralci P-gp lahko povečajo razmerje koncentracij med tkivi in plazmo.
English: The primary endpoint was a composite of cardiovascular and renal complications.
Slovenian: Primarni cilj opazovanja je bil sestavljen iz srčnožilnih in ledvičnih zapletov.
English: All three doses were well tolerated in both elderly and very elderly patients.
Slovenian: Tako starejši kot zelo stari bolniki so vse tri odmerke dobro prenašali.
English: Aliskiren should be used with caution in patients with serious congestive heart failure (New York Heart Association [NYHA] functional class III-IV).
Slovenian: Previdnost je potrebna pri uporabi aliskirena pri bolnikih z resnim kongestivnim srčnim popuščanjem (funkcijskih razredov III-IV po klasifikaciji Newyorškega združenja za srce (New York Heart Association [NYHA])).
English: The MAH shall perform the pharmacovigilance activities detailed in the Pharmacovigilance Plan, as agreed in the RMP presented in Module 1.8.2 of the Marketing Authorisation and any subsequent updates of the RMP agreed by the Committee for Medicinal Products for Human Use (CHMP).
Slovenian: Imetnik dovoljenja za promet z zdravilom bo izvedel farmakovigilančne aktivnosti, podrobno opisane v načrtu farmakovigilance, sprejetem v RMP, predloženem v modulu 1.8.2 dovoljenja za promet z zdravilom, in vseh nadaljnjih posodobitvah RMP v soglasju z Odborom za zdravila za uporabo v humani medicini (CHMP).
English: Preliminary study results indicated a hazard ratio for the primary endpoint of 1.09 in favour of placebo (95% Confidence Interval: 0.97, 1.22, 2-sided p=0.17).
Slovenian: Predčasni rezultati študije so pokazali, da je pri primarnem cilju opazovanja razmerje ogroženosti (hazard ratio, HR) 1,09 v prid placeba (s 95-odstotnim intervalom zaupanja 0,97, 1,22 in z dvosmerno vrednostjo p=0,17).
English: The study was discontinued prematurely because the participants were unlikely to benefit from aliskiren.
Slovenian: Študijo so predčasno zaključili, ker ni kazalo, da bi aliskiren preiskovancem lahko koristil.
English: Sprimeo was not teratogenic in rats or rabbits (see section 5.3).
Slovenian: Zdravilo Sprimeo ni bilo teratogeno pri podganah ali kuncih (glejte poglavje 5.3).
English: Like all medicines, Sprimeo can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Sprimeo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: PVC/polychlorotrifluoroethylene (PCTFE) - Alu blisters:
Slovenian: PVC/poliklorotrifluoroetilen (PCTFE) - Alu pretisni omoti:
English: PA/Alu/PVC - Alu blisters:
Slovenian: PA/Alu/PVC - Alu pretisni omoti:
English: Aliskiren is an effective once-a-day antihypertensive treatment in adult patients, regardless of gender, age, body mass index and ethnicity.
Slovenian: Aliskiren predstavlja učinkovito antihipertenzivno zdravljenje za enkrat dnevno odmerjanje pri odraslih bolnikih ne glede na spol, starost, indeks telesne mase in etnično pripadnost.
English: The usual starting dose is one 150 mg tablet once daily.
Slovenian: Običajni začetni odmerek je ena 150-miligramska tableta enkrat na dan.
English: Findings during repeat-dose toxicity studies in animals were consistent with the known local irritation potential or the expected pharmacological effects of aliskiren.
Slovenian: Rezultati toksikoloških študij ponovljenih odmerkov na živalih so bili skladni z znano možnostjo draženja ali s pričakovanimi farmakološkimi učinki aliskirena.
English: Blood creatinine increased
Slovenian: zvišana vrednost kreatinina v krvi
English: Following intravenous administration, the mean plasma clearance is approximately 9 l/h.
Slovenian: Po intravenski aplikaciji je povprečni plazemski očistek približno 9 l/h.
English: Furosemide
Slovenian: Furosemid
English: The blood-pressure-lowering effect was sustained during long-term treatment, and was independent of age, gender, body mass index and ethnicity.
Slovenian: Učinek zniževanja krvnega tlaka se je ohranjal pri dolgotrajnem zdravljenju in je bil neodvisen od starosti, spola, indeksa telesne mase in etnične pripadnosti.
English: Reducing the amount of angiotensin II allows the blood vessels to relax, which lowers blood pressure.
Slovenian: Zmanjšanje količine angiotenzina II omogoči krvnim žilam, da se sprostijo, kar zniža krvni tlak.
English: Cardiac electrophysiology
Slovenian: Elektrofiziologija srca
English: Sprimeo has negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Sprimeo ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: Do not store above 30C.
Slovenian: Shranjujte pri temperaturi do 30 C.
English: 85 to 90% of the maximal bloodpressure-lowering effect was observed after 2 weeks.
Slovenian: Po dveh tednih so opažali izraženost 85 do 90 % največjega učinka zniževanja krvnega tlaka.
English: However, the use of aliskiren is not recommended in patients with severe renal impairment (see section 4.4).
Slovenian: Kljub temu pa uporaba aliskirena ni priporočena pri bolnikih s hudo okvaro ledvic (glejte poglavje 4.4).
English: No patients discontinued therapy due to anaemia.
Slovenian: Noben bolnik ni prekinil zdravljenja zaradi slabokrvnosti.
English: What Sprimeo is and what it is used for Before you take Sprimeo How to take Sprimeo Possible side effects How to store Sprimeo Further information
Slovenian: Kaj je zdravilo Sprimeo in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Sprimeo Kako jemati zdravilo Sprimeo Možni neželeni učinki
English: Therefore, because of the risk of therapeutic failure, grapefruit juice should not be taken together with Sprimeo.
Slovenian: Ker bi torej lahko prišlo do zmanjšanja terapevtskega učinka, se grenivkinega soka ne sme uživati skupaj z zdravilom Sprimeo.
English: The combined rates of cardiovascular death, hospitalisation for heart failure, recurrent heart attack, stroke and resuscitated sudden death were similar in the aliskiren group and the placebo group.
Slovenian: Kombinirani deleži kardiovaskularnih smrti, hospitalizacij zaradi srčnega popuščanja, ponovnih srčnih infarktov, možganskih kapi in reanimiranih primerov nenadne smrti so bili v skupini z aliskirenom podobni kot v skupini s placebom.
English: Sprimeo was secreted in the milk of lactating rats.
Slovenian: Zdravilo Sprimeo se je izločalo v mleko doječih podgan.
English: Therefore, P-gp inhibitors may increase tissue levels more than plasma levels.
Slovenian: Zato lahko zaviralci P-gp povišajo koncentracije v tkivih bolj kot koncentracije v plazmi.
English: In the event of severe and persistent diarrhoea, Sprimeo therapy should be stopped.
Slovenian: V primeru hude ali persistentne driske je treba zdravljenje z zdravilom Sprimeo prekiniti.
English: Following oral absorption, peak plasma concentrations of aliskiren are reached after 1-3 hours.
Slovenian: Po peroralni absorpciji doseže aliskiren največje koncentracije v plazmi po 1 - 3 urah.
English: Angiotensin II causes blood vessels to tighten, which increases the blood pressure.
Slovenian: Angiotenzin II povzroči, da se krvne žile stisnejo, kar zviša krvni tlak.
English: These combinations were well tolerated.
Slovenian: Bolniki so navedene kombinacije zdravil dobro prenašali.
English: The doses in rats and rabbits provided systemic exposures of 1 to 4 and 5 times higher, respectively, than the maximum recommended human dose (300 mg).
Slovenian: Odmerjanje pri podganah in kuncih je povzročilo sistemsko izpostavljenost zdravilu, ki je bila pri podganah 1 do 4-krat večja, pri kuncih pa 5-krat večja kot pri najvišjem priporočenem odmerku za človeka (300 mg).
English: In addition, an increased incidence of serious adverse outcomes was observed with aliskiren compared to placebo for renal complications (4.7% versus 3.3%), hyperkalaemia (36.9% versus 27.1%), hypotension (18.4% versus 14.6%) and stroke (2.7% versus 2.0%).
Slovenian: Poleg tega so pri uporabi aliskirena v primerjavi s placebom opažali povečano pogostnost resnih neželenih izidov, in sicer zapletov na ledvicah (4,7 % v primerjavi s 3,3 %), hiperkaliemije (36,9 % v primerjavi s 27,1 %), hipotenzije (18,4 % v primerjavi s 14,6 %) in možganske kapi (2,7 % v primerjavi z 2,0 %).
English: Renin inhibitors reduce the amount of angiotensin II the body can produce.
Slovenian: Zaviralci renina zmanjšujejo količino angiotenzina II, ki nastaja v telesu.
English: Gender, weight and ethnicity have no clinically relevant influence on aliskiren pharmacokinetics.
Slovenian: Spol, telesna masa in etnična pripadnost nimajo klinično pomembnega vpliva na farmakokinetične lastnosti aliskirena.
English: Reproductive toxicity studies with aliskiren did not reveal any evidence of embryofoetal toxicity or teratogenicity at doses up to 600 mg/kg/day in rats or 100 mg/kg/day in rabbits.
Slovenian: V študijah vpliva na sposobnost razmnoževanja z aliskirenom niso zasledili znakov toksičnosti za zarodek oziroma plod ali teratogenosti pri odmerkih do 600 mg/kg/dan pri podganah oziroma 100 mg/kg/dan pri kuncih.
English: Patients with a history of angioedema may be at increased risk of experiencing angioedema during treatment with aliskiren (see sections 4.3 and 4.8).
Slovenian: Pri bolnikih, ki so že imeli angioedem, je lahko tveganje za angioedem med zdravljenjem z aliskirenom povečano (glejte poglavji 4.3 in 4.8).
English: Therefore, caution should be exercised when aliskiren is administered with ketoconazole, verapamil or other moderate P-gp inhibitors (clarithromycin, telithromycin, erythromycin, amiodarone).
Slovenian: Zato je potrebna previdnost pri sočasni uporabi aliskirena s ketokonazolom, z verapamilom ali z drugimi zmernimi zaviralci P-gp (klaritomicinom, telitromicinom, eritromicinom, amiodaronom).
English: It is therefore recommended that the effects be monitored when initiating and adjusting furosemide therapy to avoid possible underutilisation in clinical situations of volume overload.
Slovenian: Zato je pri uvedbi in prilagajanju zdravljenja s furosemidom priporočljivo spremljanje učinkov, da ne bi uporabljali premajhnih odmerkov v stanjih volumske preobremenitve.
English: C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION
Slovenian: C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA
English: If this happens, stop taking Sprimeo and contact your doctor.
Slovenian: V tem primeru prenehajte jemati zdravilo Sprimeo in obvestite zdravnika.
English: Hypersensitivity reactions have also been reported in post-marketing experience.
Slovenian: Preobčutljivostne reakcije so opisovali tudi na podlagi izkušenj po prihodu zdravila na trg.
English: In a 8-week study in 754 hypertensive elderly (≥ 65 years) and very elderly patients (30% ≥ 75 years) aliskiren at doses of 75 mg, 150 mg and 300 mg provided statistically significant superior reduction in blood pressure (both systolic and diastolic) when compared to placebo.
Slovenian: V 8-tedenski študiji je pri 754 hipertenzivnih starejših (≥ 65 let) in zelo starih (30% ≥ 75 let) bolnikih aliskiren v odmerkih 75 mg, 150 mg in 300 mg znižal krvni tlak (sistolični in diastolični) statistično značilno bolj kot placebo.
English: In controlled clinical trials, angioedema and hypersensitivity reactions occurred rarely during treatment with aliskiren with rates comparable to treatment with placebo or comparators.
Slovenian: V kontroliranih kliničnih preskušanjih je med zdravljenjem z aliskirenom redko prišlo do angioedema in preobčutljivostnih reakcij in sicer s pogostnostjo, ki je bila primerljiva z zdravljenjem s placebom ali s primerjalnimi zdravili.
English: In a study conducted in patients with end stage renal disease (ESRD) receiving haemodialysis, dialysis clearance of aliskiren was low (< 2% of oral clearance).
Slovenian: V študiji, ki so jo izvajali pri bolnikih s končno ledvično odpovedjo, ki so se zdravili s hemodializo, je bil dializni očistek aliskirena nizek (< 2 % peroralnega očistka).
English: Aliskiren is an orally active, non-peptide, potent and selective direct inhibitor of human renin.
Slovenian: Aliskiren je peroralno delujoč nepeptiden močan in selektiven neposreden zaviralec človeškega renina.
English: Compounds that have been investigated in clinical pharmacokinetic studies include acenocoumarol, atenolol, celecoxib, pioglitazone, allopurinol, isosorbide-5-mononitrate and hydrochlorothiazide.
Slovenian: Med učinkovinami, ki so jih raziskovali v kliničnih farmakokinetičnih študijah, so acenokumarol, atenolol, celekoksib, pioglitazon, alopurinol, izosorbid-5-mononitrat in hidroklorotiazid.