FrancophonIA/ELRC3.0 huggingface dataset:
English: • a decrease in the number of cells involved in blood clotting (thrombocytopenia), or in all kinds of blood cells (pancytopenia)
Slovenian: • znižanje števila celic, ki sodelujejo pri strjevanju krvi (trombocitopenija), ali vseh krvnih celic (pancitopenija).
English: • pyrimethamine, to treat malaria and other parasitic infections
Slovenian: • pirimetamin za zdravljenje malarije in drugih zajedavskih okužb,
English: Trizivir contains three active ingredients that are used to treat HIV infection: abacavir, lamivudine and zidovudine.
Slovenian: Zdravilo Trizivir vsebuje tri zdravilne učinkovine, ki se uporabljajo za zdravljenje okužbe z virusom HIV: abakavir, lamivudin in zidovudin.
English: The active ingredients of Trizivir may inhibit cellular DNA replication, zidovudine has been shown to be transplacental carcinogen in one animal study and abacavir has been shown to be carcinogenic in animal models (see section 5.3).
Slovenian: Učinkovine zdravila Trizivir lahko inhibirajo replikacijo celične DNK, in zidovudin se je izkazal za transplacentalno karcinogenega v študijah na živalskih modelih (glejte poglavje 5.3).
English: If you have stopped taking Trizivir
Slovenian: Če ste prenehali jemati zdravilo Trizivir
English: In vitro data tend to suggest that the continuation of lamivudine in anti-retroviral regimen despite the development of M184V might provide residual anti-retroviral activity (likely through impaired viral fitness).
Slovenian: In vitro pridobljeni podatki nakazujejo, da se pri nadaljevanju uporabe lamivudina v protiretrovirusnem režimu zdravljenja kljub pojavu variante M184V lahko zagotovi nadaljnje protiretrovirusno delovanje (verjetno zaradi okvare virusa).
English: The absolute bioavailability of oral abacavir, lamivudine and zidovudine in adults is about 83 %, 80 - 85 % and 60 - 70 % respectively.
Slovenian: Pri odraslih znaša absolutna biološka uporabnost peroralnega abakavirja približno 83 %, peroralnega lamivudina približno 80 - 85 % in peroralnega zidovudina približno 60 - 70 %.
English: • an increased amount in the blood of bilirubin (a substance produced in the liver) which may make your skin appear yellow
Slovenian: • zvišanje bilirubina (snovi, ki nastaja v jetrih) v krvi, zaradi česar se lahko pojavi porumenelost kože.
English: Other medicines and Trizivir
Slovenian: Druga zdravila in zdravilo Trizivir
English: In rare cases, as the immune system becomes stronger, it can also attack healthy body tissue (autoimmune disorders).
Slovenian: V redkih primerih se lahko zgodi, da okrepljeni imunski sistem napade zdrava telesna tkiva (avtoimunske bolezni).
English: Dose reduction is required for patients with creatinine clearance ≤ 50 ml/min (see section 4.2).
Slovenian: Pri bolnikih s kreatininskim očistkom ≤ 50 ml/min je potrebno odmerek zmanjšati (glejte poglavje 4.2).
English: Blue-green capsule-shaped film-coated tablets engraved with “GX LL1” on one side.
Slovenian: Modrozelene filmsko obložene tablete v obliki kapsule, na eni strani imajo odtisnjeno oznako “GX LL1”.
English: Some people taking combination therapy for HIV develop a condition called osteonecrosis.
Slovenian: Nekaterim uporabnikom kombiniranega zdravljenja HIV se pojavi motnja, imenovana osteonekroza.
English: Treatment with zidovudine has been associated with cases of lactic acidosis, sometimes fatal, usually associated with severe hepatomegaly and hepatic steatosis, (see section 4.4).
Slovenian: Pri uporabi zidovudina so poročali o primerih laktacidoze, včasih s smrtnim izidom, navadno v povezavi s hudo hepatomegalijo in steatozo jeter (glejte poglavje 4.4).
English: Some people taking Trizivir are more at risk of serious side effects.
Slovenian: Nekatere prejemnike zdravila Trizivir bolj ogrožajo resni neželeni učinki.
English: Opadry Green 03B11434 containing: hypromellose, titanium dioxide, polyethylene glycol, indigo carmine aluminium lake, iron oxide yellow.
Slovenian: Opadry Green 03B11434, ki vsebuje: hipromelozo, titanov dioksid, makrogol, indigotin, rumeni železov oksid.
English: All of these belong to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Slovenian: Vse te učinkovine spadajo v skupino protiretrovirusnih zdravil, ki jih imenujemo zaviralci nukleotidne in nukleozidne reverzne transkriptaze (NRTI-ji).
English: Some clinical findings also support a possible interaction between lamivudine and cladribine.
Slovenian: Tudi nekatere klinične ugotovitve potrjujejo možno medsebojno delovanje med lamivudinom in kladribinom.
English: Rarely, patients who have stopped abacavir for reasons other than symptoms of HSR have also experienced life-threatening reactions within hours of re- initiating abacavir therapy (see Section 4.8 Description of selected adverse reactions).
Slovenian: V redkih primerih so se pri bolnikih, ki so abakavir nehali jemati zaradi drugih razlogov, ne zaradi simptomov HSR, v nekaj urah po ponovni uvedbi zdravljenja z abakavirjem, pojavile življenjsko nevarne reakcije (glejte poglavje 4.8, Opis izbranih neželenih učinkov).
English: Corresponding values for Cmin could not be established for abacavir and are 0.14 µg/ml (70 %) for lamivudine and 0.01 µg/ml (64 %) for zidovudine.
Slovenian: Ustreznih vrednosti Cmin za abakavir ni bilo mogoče ugotoviti, Cmin lamivudina je bila 0,14 µg/ml (70 %), Cmin zidovudina pa 0,01 µg/ml (64 %).
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: Poleg tega je treba posodobljen RMP predložiti:  na zahtevo Evropske agencije za zdravila;  ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: • a low red blood cell count (anaemia) or low white blood cell count (neutropenia or leucopenia)
Slovenian: • majhno število rdečih krvnih celic (anemija) ali majhno število belih krvnih celic (nevtropenija ali levkopenija),
English: Before initiating treatment with abacavir, screening for carriage of the HLA-B*5701 allele should be performed in any HIV-infected patient, irrespective of racial origin(see section 4.4).
Slovenian: Pred uvedbo zdravljenja z abakavirjem je pri vsakem bolniku, okuženim z virusom HIV, treba opraviti presejalni test za prisotnost alela HLA-B*5701, ne glede na rasno poreklo (glejte poglavje 4.4).
English: MISCELLANEOUS Ethanol/Abacavir (0.7 g/kg single dose/600mg single dose)
Slovenian: RAZNO etanol/abakavir (0.7 g/kg enkratni odmerek/600mg enkrati odmerek)
English: Rare: pancreatitis
Slovenian: Redki: pankreatitis
English: Rare: gynaecomastia
Slovenian: Redki: ginekomastija
English: Remember to tell your doctor or pharmacist if you begin taking a new medicine while you are taking Trizivir.
Slovenian: Zdravniku ali farmacevtu morate vedno povedati, če med zdravljenjem z zdravilom Trizivir začnete jemati kakšno novo zdravilo.
English: • a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome), and a more severe form causing skin peeling in more than
Slovenian: • razširjen izpuščaj z mehurji in lupljenjem kože, zlasti okrog ust, nosu, oči in spolovil (StevensJohnsonov sindrom), ter hujša oblika, ki povzroči lupljenje več kot 30 % površine telesa (toksična epidermalna nekroliza).
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART - combination antiretroviral therapy) ali obojim.
English: • difficulty breathing
Slovenian: • težko dihanje.
English: • ribavirin or injections of ganciclovir to treat viral infections
Slovenian: • ribavirina ali injekcij ganciklovirja za zdravljenje virusnih okužb,
English: Neither abacavir, lamivudine nor zidovudine is mutagenic in bacterial tests, but consistent with other nucleoside analogues, they inhibit cellular DNA replication in in vitro mammalian tests such as the mouse lymphoma assay.
Slovenian: Abakavir, lamivudin ali zidovudin v poskusih z bakterijami niso pokazali mutagenosti, vendar, skladno z drugimi nukleozidnimi analogi, inhibirajo replikacijo celične DNK v in vitro testih na celicah sesalcev, kot so celice mišjega limfoma.
English: • an increase in the level of liver enzymes
Slovenian: • zvišanje jetrnih encimov,
English: In vitro resistance
Slovenian: Odpornost in vitro
English: The likelihood of metabolic drug interactions with lamivudine is low due to the small extent of hepatic metabolism (5 - 10 %) and low plasma binding.
Slovenian: Verjetnost presnovnih interakcij z drugimi zdravili je majhna zaradi majhnega obsega jetrne presnove (5 do 10 %) in majhne vezave na plazemske proteine.
English: No pharmacokinetic data are available in patients over 65 years of age.
Slovenian: Starostniki Za bolnike, starejše od 65 let, podatki o farmakokinetiki niso na voljo.
English: Rare: urinary frequency
Slovenian: Redki: spremenjena pogostnost uriniranja
English: In a meta-analysis of five clinical trials where abacavir was added to intensify therapy, of 166 subjects, 123 (74 %) had M184V/I, 50 (30 %) had T215Y/F, 45 (27%) had M41L, 30 (18 %) had K70R and 25 (15%) had D67N.
Slovenian: V metaanalizi petih kliničnih preskušanj, v katerih je bil abakavir dodan 166 osebam zaradi stopnjevanja zdravljenja, je 123 oseb (74 %) imelo M184V/I, 50 oseb (30 %) T215Y/F, 45 oseb (27 %) M41L, 30 oseb (18 %) K70R in 25 oseb (15 %) D67N.
English: The pharmacokinetics of abacavir in patients with end-stage renal disease is similar to patients with normal renal function, and, therefore, no dose reduction is required in patients with renal impairment.
Slovenian: Pri bolnikih s terminalnim stadijem ledvične bolezni je farmakokinetika abakavirja podobna kot pri bolnikih z normalnim ledvičnim delovanjem, zato pri bolnikih z oslabljenim delovanjem ledvic odmerkov ni potrebno prilagajati.
English: The results showed that there was a mean (90%CI) increase of 1.89 fold [1.32; 2.70] in the abacavir AUC, and 1.58 [1.22; 2.04] fold in the elimination half-life.
Slovenian: Rezultati so pokazali, da je bila AUC abakavirja povečana v povprečju za 1,89-krat [1,32; 2,70]; 90 % interval zaupanja, eliminacijski razpolovni čas pa v povprečju za 1,58-krat [1,22; 2,04]; 90 % interval zaupanja.
English: Due to the active substance zidovudine, Trizivir is contraindicated in patients with abnormally low neutrophil counts (< 0.75 x 109/l), or abnormally low haemoglobin levels (< 7.5 g/dl or 4.65 mmol/l) (see section 4.4).
Slovenian: Zaradi učinkovine zidovudin je zdravilo Trizivir kontraindicirano pri bolnikih z izredno nizkim številom nevtrofilcev (< 0,75 x 109/l) ali izredno nizkimi vrednostmi hemoglobina (< 7,5 g/dl ali 4,65 mmol/l) (glejte poglavje 4.4).
English: The carcinogenic potential of a combination of abacavir, lamivudine and zidovudine has not been tested.
Slovenian: Morebitnega karcinogenega potenciala kombinacije abakavir, lamivudin in zidovudin še niso proučili.
English: Even patients who don't have the HLA-B*5701 gene may still develop a hypersensitivity reaction (a serious allergic reaction), described in this leaflet in the panel headed ‘Hypersensitivity reactions'.
Slovenian: Tudi pri bolnikih, ki nimajo gena HLA-B*5701, se lahko pojavi preobčutljivostna reakcija (resna alergijska reakcija), ki je v tem navodilu opisana pod naslovom »Preobčutljivostne reakcije«.
English: • irritated or runny nose
Slovenian: • razdražen nos ali izcedek iz nosu,
English: 1) you get a skin rash OR
Slovenian: 1) opazite kožni izpuščaj ALI
English: MARKETING AUTHORISATION HOLDER ViiV Healthcare BV
Slovenian: IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM ViiV Healthcare BV
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Slovenian: Pri bolnikih z obstoječimi motnjami v delovanju jeter, vključno s kroničnim aktivnim hepatitisom, se med kombiniranim protiretrovirusnim zdravljenjem pogosteje pojavljajo nepravilnosti v delovanju jeter, zato je potrebno take bolnike nadzorovati v skladu s standardno prakso.
English: HIV-1 resistance to lamivudine involves the development of a M184I or, more commonly, M184V amino acid change close to the active site of the viral RT.
Slovenian: Odpornost virusa HIV-1 proti lamivudinu obsega razvoj M184I ali pogosteje M184V aminokislinske spremembe blizu aktivnega mesta virusne RT.
English: Common: raised blood levels of liver enzymes and bilirubin Rare: liver disorders such as severe hepatomegaly with steatosis,
Slovenian: Pogosti: prehodno povečane vrednosti jetrnih encimov in bilirubina v krvi Redki: motnje v delovanju jeter, kot je huda hepatomegalija s steatozo
English: A fertility study in the rat has shown that abacavir had no effect on male or female fertility.
Slovenian: Študija plodnosti pri podganah je pokazala, da abakavir ne vpliva na plodnost samcev ali samic.
English: If you know you have this gene, tell your doctor before you take Trizivir.
Slovenian: Če veste, da imate ta gen, morate pred začetkom zdravljenja z zdravilom
English: Other symptoms include:
Slovenian: Med drugimi simptomi so:
English: The safety and efficacy of Trizivir has not been established in patients with significant underlying liver disorders.
Slovenian: Varnosti in učinkovitosti uporabe zdravila Trizivir pri bolnikih z znatnimi motnjami v delovanju jeter niso dokazali.
English: Intravenous studies with abacavir, lamivudine and zidovudine showed that the mean apparent volume of distribution is 0.8, 1.3 and 1.6 l/kg respectively.
Slovenian: Študije z intravensko aplikacijo abakavirja, lamivudina in zidovudina so pokazale, da znaša srednji navidezni volumen porazdelitve 0,8 l/kg za abakavir, 1,3 l/kg za lamivudin oziroma 1,6 l/kg za zidovudin.
English: Doctor:.......................…………………………………………… Tel:...................………………………………………… If your doctor is not available, you must urgently seek alternative medical advice (e.g. the emergency unit of the nearest hospital).
Slovenian: Če vaš zdravnik ni dosegljiv, morate nujno poiskati zdravniško pomoč drugje (npr. na urgentnem oddelku najbližje bolnišnice).
English: Trizivir is indicated for the treatment of Human Immunodeficiency Virus (HIV) infection in adults (see sections 4.4 and 5.1).
Slovenian: Zdravilo Trizivir je indicirano za zdravljenje odraslih, ki so okuženi z virusom humane imunske pomanjkljivosti (HIV) (glejte poglavji 4.4 in 5.1).
English: Talk to your doctor immediately.
Slovenian: NEMUDOMA obrnite na svojega zdravnika.
English: For patients co-infected with hepatitis who are being treated with a lamivudine containing medicinal product such as Trizivir and subsequently become pregnant, consideration should be given to the possibility of a recurrence of hepatitis on discontinuation of lamivudine.
Slovenian: Pri bolnicah, ki so hkrati okužene s hepatitisom, in prejemajo zdravilo, ki vsebuje lamivudin, npr. zdravilo Trizivir, ter zanosijo, je treba upoštevati možnost ponovitve hepatitisa po prenehanju uporabe lamivudina.
English: As well as the side effects listed below for Trizivir, other conditions can develop during treatment.
Slovenian: Poleg spodaj opisanih neželenih učinkov zdravila Trizivir se lahko med zdravljenjem pojavijo še druge motnje.
English: Because Trizivir contains abacavir, lamivudine and zidovudine, the adverse reactions associated with these compounds may be expected.
Slovenian: Ker zdravilo Trizivir vsebuje abakavir, lamivudin in zidovudin, lahko pričakujemo neželene učinke, ki so vezani na te tri učinkovine.
English: If you accidentally take too much Trizivir, tell your doctor or your pharmacist, or contact your nearest hospital emergency department for further advice.
Slovenian: Če ste vzeli večji odmerek zdravila Trizivir, kot bi smeli Če pomotoma vzamete preveč zdravila Trizivir, se nemudoma posvetujte z zdravnikom ali farmacevtom ali se za nadaljnje nasvete obrnite na bolnišnični oddelek za nujno pomoč.
English: Trizivir is not recommended in patients with moderate or severe hepatic impairment (see sections 4.2 and 5.2).
Slovenian: Zdravilo Trizivir se ne priporoča pri bolnikih, ki imajo zmerno ali hudo jetrno okvaro (glejte poglavji 4.2 in 5.2).
English: About 3 to 4 in every 100 patients treated with abacavir in a clinical trial who did not have the HLAB*5701 gene developed a hypersensitivity reaction.
Slovenian: V kliničnem preskušanju se je približno pri 3 do 4 od 100 bolnikov, ki so prejemali abakavir in niso imeli gena HLA-B*5701, pojavila preobčutljivostna reakcija.
English: Some people who take abacavir may develop a hypersensitivity reaction (a serious allergic reaction), which can be life-threatening if they continue to take abacavir containing products .
Slovenian: Nekaterim bolnikom, ki jemljejo abakavir, se lahko pojavi preobčutljivostna reakcija (resna alergijska reakcija), ki je lahko življenjsko nevarna, če še naprej jemljejo zdravila, ki vsebujejo abakavir.
English: Abacavir, lamivudine and zidovudine triphosphates show significantly less affinity for host cell DNA polymerases.
Slovenian: Abakavir, lamivudin in zidovudin trifosfati imajo občutno manjšo afiniteto do DNK polimeraz gostiteljske celice.
English: Major symptoms associated with ABC HSR are fever (~80%), rash (~70%), gastrointestinal symptoms (>50%) such as nausea, abdominal pain, vomiting, and diarrhoea, generalise malaise, fatigue, and headache (~50%) and other symptoms (~30%) such as respiratory, mucosal, and musculoskeletal symptoms.
Slovenian: Diagnoza preobčutljivostne reakcije na abakavir Glavni simptomi, povezani s preobčutljivostnimi reakcijami na ABC so povišana telesna temperatura (~80 %), izpuščaj (~70 %), gastrointestinalni simptomi (> 50 %), npr. navzea, bolečine v trebuhu, bruhanje in driska, splošno slabo počutje, utrujenost in glavobol (~50 %) in drugi simptomi (~30 %), npr. simptomi s strani dihal, sluznic in kostno-mišični simptomi.
English: When such development is found, treatment with Trizivir should not be continued (see section 4.4).
Slovenian: V primeru razvoja lipoatrofije se ne sme nadaljevati zdravljenja z zdravilom Trizivir (glejte poglavje 4.4).
English: Musculoskeletal and connective tissue disorders Common: arthralgia, muscle disorders
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva Pogosti: artralgija, mišične motnje
English: • if their immune systems are very weak
Slovenian: • ki imajo oslabel imunski sistem,
English: TRIZIVIR TABLETS ALERT CARD (blister and bottle pack)
Slovenian: OPOZORILNA KARTICA ZA TRIZIVIR TABLETE (pakiranje v pretisnem omotu in plastenki)
English: Trizivir can make you dizzy and have other side effects that make you less alert.
Slovenian: Zdravilo Trizivir lahko povzroči omotico in druge neželene učinke, ki lahko poslabšajo pozornost.
English: Tablet Coating:
Slovenian: Obloga tablete:
English: • if you are allergic (hypersensitive) to abacavir (or any other medicine containing abacavirKivexa, Triumeq or Ziagen), lamivudine or zidovudine, or any of the other ingredients of this medicine (listed in Section 6) Carefully read all the information about hypersensitivity reactions in Section 4.
Slovenian: • če ste alergični (preobčutljivi) na abakavir (ali katerokoli drugo zdravilo, ki vsebuje abakavirKivexa, Triumeq ali Ziagen), lamivudin ali zidovudin ali katerokoli drugo sestavino tega zdravila (navedeno v poglavju 6).
English: A moderate amount of data on pregnant women taking the individual actives abacavir, lamivudine and zidovudine in combination indicates no malformative toxicity (more than 300 outcomes from first trimester exposures).
Slovenian: Zmerna količina podatkov o nosečnicah, ki so jemale individualno aktivno kombinacijo abakavirja, lamivudina in zidovudina (več kot 300 izidov po izpostavljenosti v prvem trimesečju), niso pokazali malformacijske toksičnosti.
English: In toxicology studies abacavir was shown to increase liver weights in rats and monkeys.
Slovenian: Toksikološke študije so pokazale, da je abakavir povečal težo jeter pri podganah in opicah.
English: Common: anaemia, neutropenia and leucopenia
Slovenian: Pogosti: anemija, nevtropenija in levkopenija
English: Rare: anorexia, lactic acidosis in the absence of hypoxaemia
Slovenian: Redki: anoreksija, laktacidoza brez hipoksemije
English: Take special care with Trizivir
Slovenian: Bodite posebno pozorni pri uporabi zdravila Trizivir
English: Trizivir contains abacavir (which is also an active substance in medicines such as Kivexa, Triumeq and Ziagen).
Slovenian: Zdravilo Trizivir vsebuje abakavir (ki je tudi zdravilna učinkovina v zdravilih kot so Kivexa, Triumeq in Ziagen).
English: • liver disorders, such as jaundice, enlarged liver or fatty liver, inflammation (hepatitis)
Slovenian: • jetrne motnje, npr. zlatenica, povečanje jeter ali zamaščena jetra, vnetje jeter (hepatitis),
English: The mean ratios of CSF/serum lamivudine and zidovudine concentrations 2 - 4 hours after oral administration were approximately 0.12 and 0.5 respectively.
Slovenian: Srednje vrednosti razmerja koncentracij CST/serum lamivudina in zidovudina so znašale približno 0,12 za lamivudin oziroma 0,5 za zidovudin, 2 do 4 ure po peroralni aplikaciji.
English: The demonstration of the benefit of Trizivir is mainly based on results of studies performed in treatment naive patients or moderately antiretroviral experienced patients with non-advanced disease.
Slovenian: Korist zdravila Trizivir je bila v glavnem prikazana z rezultati študij, ki so bile opravljene pri bolnikih, ki s protiretrovirusnimi zdravili še niso bili zdravljeni ali pri bolnikih z nenapredovano boleznijo, ki so bili s protiretrovirusnimi zdravili zdravljeni zmerno.
English: Common: rash, alopecia
Slovenian: Pogosti: izpuščaj, alopecija
English: Zidovudine AUC ↑33% Atovaquone AUC ↔
Slovenian: zidovudin AUC ↑33% atovakon AUC ↔
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and can occur many months after initiation of treatment.
Slovenian: V okviru imunske reaktivacije je bil opisan tudi pojav avtoimunskih bolezni (npr. pojav Gravesove bolezni in avtoimunskega hepatitisa), toda opisani čas do začetka je bolj spremenljiv in ti dogodki se lahko pojavijo veliko mesecev po uvedbi zdravljenja.
English: The presence of M184V with K65R does give rise to crossresistance between abacavir, tenofovir, didanosine and lamivudine, and M184V with L74V gives rise to cross-resistance between abacavir, didanosine and lamivudine.
Slovenian: povzroči navzkrižno odpornost med abakavirjem, tenofovirjem, didanozinom in lamivudinom ter prisotnost M184V z L74V povzroči navzkrižno odpornost med abakavirjem, didanozinom in lamivudinom.
English: At a therapeutic dose (one Trizivir tablet twice daily) in patients, the mean (CV) steady-state Cmax of abacavir, lamivudine and zidovudine in plasma are 3.49 µg/ml (45 %), 1.33 µg/ml (33 %) and 1.56 µg/ml (83 %), respectively.
Slovenian: Pri terapevtskih odmerkih (ena tableta zdravila Trizivir dvakrat dnevno) so bile pri bolnikih srednje Cmax v ravnotežnem stanju: za abakavir 3,49 µg/ml (45 %), za lamivudin 1,33 µg/ml (33 %) in za zidovudin 1,56 µg/ml (83 %).