FrancophonIA/ELRC3.0 huggingface dataset:
English: In addition, pharmacokinetic modeling and simulation of darunavir exposures in paediatric patients across the ages of 3 to < 18 years confirmed the darunavir exposures as observed in the clinical studies and allowed the identification of weight-based darunavir/ritonavir once daily dosing regimens for paediatric patients weighing at least 15 kg that are either ART-naïve or treatment-experienced paediatric patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: Yderligere bekræftede en farmakokinetisk model og simulering af darunavireksponeringer hos pædiatriske patienter i alderen 3 til < 18 år de darunavireksponeringer, som blev observeret i de kliniske studier, og gav mulighed for at fastlægge vægtbaserede doser af darunavir/ritonavir en gang dagligt hos pædiatriske patienter med en legemsvægt på mindst 15 kg, som er enten ART-naive eller behandlingserfarne uden DRV-RAMs* og med plasma-hiv-1-RNA < 100.000 kopier/ml og CD4+celletal ≥ 100 x 10
English: In most cases, darunavir can be combined with anti-HIV medicines belonging to another class [e.g. NRTIs (nucleoside reverse transcriptase inhibitors), NNRTIs (non-nucleoside reverse transcriptase inhibitors), CCR5 antagonists and FIs (fusion inhibitors)].
Danish: Darunavir kan oftest kombineres med anti-hiv-lægemidler, der hører hjemme i en anden kategori [f.eks. NRTI'ere (nukleosid revers transkriptase-hæmmere), NNRTI'ere (non-nukleotid revers transkriptase-hæmmere), CCR5-antagonister og FI'er (fusionshæmmere)].
English: ● antiretroviral therapy (ART)-naïve (see section 4.2).
Danish: ● som ikke tidligere har fået antiretroviral behandling (ART-naive) (se pkt.
English: Darunavir cannot work properly without ritonavir.
Danish: Darunavir Mylan virker ikke korrekt uden ritonavir.
English: The combination of rifapentine and boosted darunavir is not recommended.
Danish: Kombinationen af rifapentin og boostet darunavir frarådes.
English: You must take darunavir every day and always in combination with 150 milligram of cobicistat or 100 milligram of ritonavir and with food.
Danish: Du skal tage darunavir hver dag og altid i kombination med 150 mg cobicistat eller 100 mg ritonavir samt mad.
English: 100 milligram a ritonavir oral solution: 80 milligram per milliliter
Danish: 100 mg a ritonavir oral opløsning: 80 mg/ml
English: Uncommon increased alanine aminotransferase hepatitis, cytolytic hepatitis, hepatic steatosis, hepatomegaly, increased transaminase, increased aspartate aminotransferase, increased blood bilirubin, increased blood alkaline phosphatase, increased gamma-glutamyltransferase
Danish: Ikke almindelig hepatitis, cytolytisk hepatitis, hepatisk steatose, hepatomegali, forhøjet aminotransferase, forhøjet aspartat-aminotranferase, forhøjet bilirubin i blodet, forhøjet alkalisk fosfatase, forhøjet gamma-glutamyltransferase
English: In the virologic failures of the ARTEMIS trial no cross-resistance with other PIs was observed.
Danish: Der blev ikke observeret nogen krydsresistens med andre PI i de virologiske svigt fra ARTEMISstudiet.
English: Cobicistat and ritonavir inhibit CYP3A, thereby increasing the plasma concentrations of darunavir considerably.
Danish: Cobicistat og ritonavir hæmmer CYP3A, hvilket øger plasmakoncentrationen af darunavir betragteligt.
English: Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of these compounds and consequently that of darunavir, leading to loss of therapeutic effect and possible development of resistance (see sections 4.3 and 4.4).
Danish: Lægemidler, som inducerer CYP3A-aktivitet, må forventes at øge darunavir- og ritonavir-clearance, hvilket ville forårsage reducerede plasmakoncentrationer af disse stoffer og efterfølgende tab af terapeutisk effekt af darunavir og mulig resistensudvikling (se pkt.
English: Concomitant use of darunavir coadministered with low dose ritonavir and these antidepressants may increase concentrations of the antidepressant.
Danish: Samtidig brug af darunavir coadministreret med lavdosis ritonavir og disse antidepressiva kan øge koncentrationerne af antidepressivummet.
English: No adjustment of methadone dosage is required when initiating co-administration with darunavir/ritonavir.
Danish: Det er ikke nødvendigt at justere methadondosis, når der påbegyndes behandling med darunavir/ritonavir.
English: Darunavir might reduce its effectiveness.
Danish: Darunavir kan nedsætte virkningen af disse.
English: Medicinal products that affect darunavir/ritonavir exposure Darunavir and ritonavir are metabolised by CYP3A.
Danish: Lægemidler, der påvirker eksponeringen for darunavir/ritonavir Darunavir og ritonavir metaboliseres via CYP3A.
English: Darunavir Mylan with food and drink See section 3 ‘How to take Darunavir Mylan'.
Danish: Darunavir Mylan med mad og drikke Se afsnittet 'Sådan tages Darunavir Mylan'.
English: If there is evidence of new or worsening liver dysfunction (including clinically significant elevation of liver enzymes and/or symptoms such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) in patients using darunavir used in combination with cobicistat or low dose ritonavir, interruption or discontinuation of treatment should be considered promptly.
Danish: Ved nye tilfælde eller forværring af leverdysfunktion (med klinisk signifikant forhøjelse af leverenzymer og/eller symptomer såsom træthed, anoreksi, kvalme, gulsot, mørkfarvning af urin, ømhed over leveren, hepatomegali) hos patienter, der anvender darunavir anvendt i kombination med cobicistat eller lavdosis ritonavir, bør det overvejes omgående at seponere behandlingen eller indstille den midlertidigt.
English: Plasma concentrations of these medicinal products may be increased when co-administered with boosted darunavir, resulting in reduced serum cortisol concentrations.
Danish: Plasmakoncentrationer af disse lægemidler kan stige ved samtidig administration af boostet darunavir, hvilket fører til reducerede serumkortisolkoncentrationer.
English: The use of darunavir coadministered with low dose ritonavir and these anticoagulants is not recommended.
Danish: Brugen af darunavir coadministreret med lavdosis ritonavir og disse antikoagulantia frarådes.
English: Co-administration of darunavir and ritonavir and other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (e.g. indinavir, azole antifungals like clotrimazole).
Danish: Co-administration af darunavir og ritonavir og andre lægemidler, der hæmmer CYP3A, kan nedsætte clearance af darunavir og ritonavir og kan medføre øgede plasmakoncentrationer af darunavir og ritonavir (f.eks. indinavir, azolantimykotika som clotrimazol).
English: A dose decrease may be needed for these drugs when co-administered with darunavir co-administered with low dose ritonavir.
Danish: Det kan være nødvendigt at nedsætte dosis af disse lægemidler ved coadministration med darunavir co-administreret med lavdosis ritonavir.
English: Clinical monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with boosted darunavir.
Danish: Klinisk monitorering af terapeutiske og uønskede virkninger anbefales, når disse lægemidler administreres sammen med boostet darunavir.
English: Darunavir Mylan 75 mg film-coated tablets Darunavir Mylan 150 mg film-coated tablets Darunavir Mylan 300 mg film-coated tablets Darunavir Mylan 600 mg film-coated tablets
Danish: Darunavir Mylan 75 mg filmovertrukne tabletter Darunavir Mylan 150 mg filmovertrukne tabletter Darunavir Mylan 300 mg filmovertrukne tabletter Darunavir Mylan 600 mg filmovertrukne tabletter
English: The pharmacokinetic properties of darunavir, co-administered with ritonavir, have been evaluated in healthy adult volunteers and in HIV-1 infected patients.
Danish: De farmakokinetiske egenskaber af darunavir co-administreret med ritonavir er blevet vurderet hos raske, voksne, frivillige forsøgspersoner og hos hiv-1-inficerede patienter.
English: 600 milligram
Danish: 600 mg
English: The maraviroc dose should be 150 mg twice daily when coadministered with darunavir with low dose ritonavir.
Danish: Maraviroc-dosis skal være 150 mg x 2, når det administreres sammen med darunavir og lavdosis ritonavir.
English: Polyvinyl alcohol, partially hydrolysed Titanium dioxide (E171) Macrogol
Danish: Polyvinylalkohol - delvist hydrolyseret Titandioxid (E171)
English: Rare myalgia, osteonecrosis, muscle spasms, muscular weakness, arthralgia, pain in extremity, osteoporosis, increased blood creatine phosphokinase musculoskeletal stiffness, arthritis, joint stiffness
Danish: Sjælden myalgi, osteonekrose, muskelspasmer, muskelsvaghed, artralgi, smerter i ekstremiteter, osteoporose, forhøjet kreatinkinase i blodet stivhed i skeletmuskulaturen, artritis, ledstivhed
English: One ritonavir a dose is between 15 and 30 kilograms
Danish: En dosis ritonavir a er mellem 15 og 30 kg
English: No adjustment of methadone dosage is required when initiating coadministration with boosted darunavir.
Danish: Det er ikke nødvendigt at justere methadondosis, når der påbegyndes behandling med boostet darunavir.
English: Darunavir 400 mg or 800 mg must always be given orally with cobicistat or low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products (see section 5.2).
Danish: Darunavir 400 mg eller 800 mg skal altid gives oralt sammen med cobicistat eller lavdosis ritonavir som farmakokinetisk forstærker og i kombination med andre antiretrovirale lægemidler (se pkt.
English: Do not combine darunavir with products that contain St John's wort (Hypericum perforatum).
Danish: Kombinér ikke darunavir med produkter, som indeholder perikon (hyperricum perforatum).
English: copies/ml) b IAS-USA lists
Danish: IAS-USA-lister c
English: If antidepressants are co-administered with boosted darunavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Danish: Hvis antidepressiva coadministreres med boostet darunavir, anbefales dosistitrering af dosis af antidepressivummet ud fra en klinisk vurdering af antidepressivt respons.
English: 400/100 mg twice daily
Danish: 400/100 mg x 2
English: BGP Products Switzerland GmbH Eesti filiaal
Danish: BGP Products UAB
English: If antidepressants are coadministered with darunavir with low dose ritonavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Danish: Hvis antidepressiva coadministreres med darunavirmed lavdosis ritonavir, anbefales dosistitrering af antidepressivummet ud fra en klinisk vurdering af antidepressivt respons.
English: In-use shelf life after first opening HDPE bottle: 100 days.
Danish: Holdbarhed når HDPE-flasken først er åbnet: 100 dage.
English: 150 mg twice daily
Danish: 150 mg x 2
English: Keep this medicine out of the sight and reach of children.
Danish: Opbevar denne medicin utilgængeligt for børn.
English: EXP Once opened, use within 90 days
Danish: EXP Skal anvendes inden for 90 dage efter anbrud
English: If concomitant use of darunavir co-administered with low dose ritonavir with sildenafil, vardenafil or tadalafil is indicated, sildenafil at a single dose not exceeding 25 mg in 48 hours, vardenafil at a single dose not exceeding 2.5 mg in 72 hours or tadalafil at a single dose not exceeding 10 mg in 72 hours is recommended.
Danish: Hvis samtidig brug af sildenafil, vardenafil eller tadalafil og darunavir administreret sammen med lavdosis ritonavir er indiceret, anbefales det at give en enkeltdosis sildenafil på højst 25 mg i løbet af 48 timer, en enkeltdosis vardenafil på højst 2,5 mg i løbet af 72 timer eller en enkeltdosis tadalafil på højst 10 mg i løbet af 72 timer.
English: Always take with cobicistat or ritonavir and food.
Danish: Du skal altid tage darunavir med cobicistat eller ritonavir og mad.
English: Reproductive system and breast disorders Uncommon erectile dysfunction, gynaecomastia General disorders and administration site conditions Common
Danish: Det reproduktive system og mammae Ikke almindelig erektil dysfunktion, gynækomasti Almene symptomer og reaktioner på administrationsstedet Almindelig asteni, træthed
English: administering darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered.
Danish: Klinisk monitorering anbefales ved co-administration af darunavir med disse sedativa/hypnotika, og en lavere dosis af sedativa/hypnotika bør overvejes.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with darunavir co-administered with low dose ritonavir is required.
Danish: Dosisreduktion eller seponering af colchicin anbefales hos patienter med normal nyre- og leverfunktion, hvis behandling med darunaviradministreret sammen med lavdosis ritonavir er nødvendig.
English: Boceprevir 800 mg three times daily boceprevir AUC ↓ 32% boceprevir Cmin ↓ 35% boceprevir Cmax ↓ 25% darunavir AUC ↓ 44% darunavir Cmin ↓ 59% darunavir Cmax ↓ 36%
Danish: boceprevir AUC ↓ 32% boceprevir Cmin ↓ 35% boceprevir Cmax ↓ 25% darunavir AUC ↓ 44% darunavir Cmin ↓ 59% darunavir Cmax ↓ 36%
English: HDPE bottle pack with a PP screw cap containing 480 tablets.
Danish: HDPE-flaskepakke med polypropylenskruelåg indeholdende 480 tabletter.
English: In the 96 week analysis, the safety profile of darunavir/ritonavir 800/100 mg once daily in treatmentnaïve subjects was similar to that seen with darunavir/ritonavir 600/100 mg twice daily in treatmentexperienced subjects except for nausea which was observed more frequently in treatment-naïve subjects.
Danish: I 96-ugers-analysen svarede sikkerhedsprofilen for darunavir/ritonavir 800/100 mg en gang dagligt hos behandlingsnaive patienter til profilen for darunavir/ritonavir 600/100 mg to gange dagligt hos behandllingserfarne patienter med undtagelse af kvalme, der sås hyppigere hos behandlingsnaive patienter.
English: tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% #darunavir AUC ↑ 21% darunavir Cmin ↑ 24% #darunavir Cmax ↑ 16% (↑ tenofovir from effect on MDR-1 transport in the renal tubules)
Danish: tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% darunavir AUC ↑ 21% darunavir Cmin ↑ 24% darunavir Cmax ↑ 16% (↑ tenofovir fra effekten på MDR-1 transport i de renale tubuli)
English: ethinylestradiol AUC ↓ 44% β ethinylestradiol Cmin ↓ 62% β
Danish: β ethinylestradiol Cmin ↓ 62%
English: - If you have any further questions, ask your doctor, pharmacist or nurse.
Danish: - Hvis du har yderligere spørgsmål, bedes du kontakte din læge, apotekspersonalet eller din sygeplejerske.
English: copies/ml at the week-8; rebound: HIV-1 RNA < 50 copies/ml followed by confirmed HIV-1 RNA to ≥ 400 copies/ml or confirmed > 1 log10 HIV-1 RNA increase from the nadir; discontinuations with HIV-1 RNA ≥ 400 copies/ml at last visit b IAS-USA lists c In GS-US216-130 baseline phenotype was not available
Danish: Virogiske svigt var defineret som: aldrig supprimeret: bekræftet HIV-1-RNA < 1 log10-reduktion fra baseline og ≥ 50 kopier/ml ved uge 8; rebound: HIV-1-RNA < 50 kopier/ml fulgt af bekræftet HIV-1-RNA til ≥ 400 kopier/ml eller bekræftet > 1 log10 HIV-1-RNA-stigning fra nadir; seponeringer med HIV-1-RNA ≥ 400 kopier/ml ved sidste besøg b
English: α1-ADRENORECEPTOR ANTAGONIST Alfuzosin
Danish: α1-ADRENORECEPTOR-ANTAGONIST
English: Clinical monitoring is recommended when co administering darunavir with low dose ritonavir and clonazepam.
Danish: Klinisk monitorering anbefales, når darunavir administreres sammen med lavdosis ritonavir og clonazepam.
English: - Take darunavir always together with 150 milligram of cobicistat or 100 milligram of ritonavir.
Danish: - Tag altid darunavir sammen med 150 mg cobicistat eller 100 mg ritonavir.
English: Darunavir Mylan 800 mg film-coated tablets PVC/PE/PVDC-Al blister pack Do not store above 25°C.
Danish: Darunavir Mylan 800 mg filmovertrukne tabletter PVC/PE/PVDC-Al-blisterpakning Må ikke opbevares ved temperaturer over 25 °C
English: ART-experienced paediatric patients (3 to 17 years of age and weighing at least 40 kg) In ART-experienced patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: ART-naive pædiatriske patienter (3 til 17 år og legemsvægt mindst 40 kg) Hos ART erfarne patienter der ikke har DRV-RAMs*, og som har plasma-hiv-1-RNA < 100.000 kopier/ml og CD4+-celletal ≥ 100 x 10
English: Boosted darunavir can be coadministered with H2-receptor antagonists without dose adjustments.
Danish: Boostet darunavir kan administreres sammen med H2-receptorantagonister uden dosisjusteringer.
English: Dose adjustment for buprenorphine may not be necessary when coadministered with boosted darunavir but a careful clinical monitoring for naloxone Cmax ↔
Danish: Dosisjustering af buprenorphin er måske ikke nødvendig ved administration sammen med boostet darunavir, men en omhyggelig klinisk monitorering for tegn på opioidtoksicitet anbefales.
English: Even if you feel better, do not stop taking Darunavir Mylan and ritonavir without talking to your doctor.
Danish: Selvom du føler, du har det bedre, så må du ikke stoppe med at tage Darunavir Mylan og ritonavir uden først at tale med din læge om det.
English: Darunavir Mylan 75 mg film-coated tablets are available in blister packs containing 480 tablets and in plastic bottles containing 480 tablets.
Danish: Darunavir Mylan 75 mg filmovertrukne tabletter fås i blisterkort med 480 tabletter og i plastikflasker med 480 tabletter.
English: Darunavir/ritonavir
Danish: β β med darunavir/ritonavir
English: Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of darunavir and ritonavir (e.g. rifampicin, St John's wort, lopinavir).
Danish: Lægemidler, der inducerer CYP3A-aktivitet, ville forventes at øge clearance af darunavir og ritonavir, hvilket medfører en lavere plasmakoncentration af darunavir og ritonavir (f.eks. rifampicin, perikon, lopinavir).
English: Immune reconstitution inflammatory syndrome
Danish: Immunrekonstitutionsinflammatorisk syndrom
English: Common side effects (may affect up to 1 in 10 people) - vomiting, nausea, abdominal pain or distension, dyspepsia, flatulence - headache, tiredness, dizziness, drowsiness, numbness, tingling or pain in hands or feet, loss of strength, difficulty falling asleep.
Danish: Almindelige bivirkninger (kan forekomme hos op til 1 ud af 10 personer) - opkastning, kvalme, mavesmerter eller -udspiling, fordøjelsesbesvær, luft i tarmene - hovedpine, træthed, svimmelhed, døsighed, følelsesløshed, prikken eller smerter i hænder eller fødder, svækkelse af styrke, besvær med at falde i søvn
English: Uncommon side effects (may affect up to 1 in 100 people) - chest pain, changes in electrocardiogram, rapid heart beating - decreased or abnormal skin sensitivity, pins and needles, attention disturbance, loss of memory,
Danish: Ikke almindelige bivirkninger (kan forekomme hos op til 1 ud af 100 personer) - brystsmerter, ændringer i elektrokardiogram, hurtig puls - nedsat eller unormal hudfølsomhed, prikkende fornemmelse, opmærksomhedsforstyrrelser,
English: ● ART-experienced with no darunavir resistance associated mutations (DRV-RAMs) and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Danish: ● som er ART-erfarne uden mutationer associeret med darunavirresistens (DRV-RAMs), og som har plasma hiv-1-RNA < 100.000 kopier/ml og CD4+-celletal ≥ 100 x 10
English: darunavir amprenavir atazanavir indinavir lopinavir saquinavir tipranavir a TLOVR non-VF censored algorithm based on HIV-1 RNA < 50 copies/ml, except for TITAN (HIV-1 RNA < 400
Danish: TLOVR non-VF censureret algoritme baseret på hiv-1-RNA < 50 kopier/ml med undtagelse af TITAN (hiv-1 RNA < 400 kopier/ml)
English: Plasma concentrations of these medicinal products may be increased when co-administered with darunavir with low dose ritonavir, resulting in reduced serum cortisol concentrations.
Danish: Plasmakoncentrationer af disse lægemidler kan stige ved samtidig administration af darunavir med lavdosis ritonavir, hvilket fører til reducerede serumkortisolkoncentrationer.
English: pravastatin Cmin ND pravastatin Cmax ↑ 63% an up to five-fold increase was seen in a limited subset of subjects
Danish: Pravastatin 40 mg som enkeldosis pravastatin AUC ↑ 81% pravastatin Cmin ND pravastatin Cmax ↑ 63% en op til 5 gangs forøgning blev set hos en begrænset undergruppe af forsøgspersoner
English: Based on theoretical considerations darunavir is expected to increase alfuzosin plasma concentrations.
Danish: Baseret på teoretiske overvejelser forventes darunavir at øge plasmakoncentrationen af alfuzosin.
English: 375 milligram darunavir + 50 milligram ritonavir twice a day between 30 and 40 kilograms
Danish: 375 mg darunavir + 50 mg ritonavir to gange dagligt mellem 30 og 40 kg
English: - Take darunavir always together with 100 milligram of ritonavir.
Danish: - Tag altid darunavir sammen med 100 mg ritonavir.
English: Darunavir binds primarily to plasma α1-acid glycoprotein.
Danish: Darunavir binder sig især til surt plasma 1glykoprotein.
English: Darunavir co-administered with low dose ritonavir and amiodarone, bepridil, dronedarone, ivabradine, quinidine, or ranolazine is contraindicated (see section 4.3).
Danish: Darunavir co-administreret med lavdosis ritonavir og amiodaron, bepridil, dronedaron, ivabradin quinidin eller ranolazin er kontraindiceret (se pkt.
English: Amitriptyline Desipramine Imipramine Nortriptyline Trazodone paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% #darunavir AUC ↔ darunavir Cmin ↔ #darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% #darunavir AUC ↔ darunavir Cmin ↓ 6% #darunavir Cmax ↔
Danish: Amitriptylin Desipramin Imipramin Nortriptylin Trazodon paroxetin AUC ↓ 39% paroxetin Cmin ↓ 37% paroxetin Cmax ↓ 36% #darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49% sertralin Cmin ↓ 49% sertralin Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
English: Efavirenz in combination with boosted darunavir once daily may result in sub-optimal darunavir Cmin.
Danish: Efavirenz i kombination med boostet darunavir en gang dagligt kan medføre suboptimal darunavir Cmin.
English: Common diarrhoea vomiting, nausea, abdominal pain, increased blood amylase, dyspepsia, abdominal distension, flatulence
Danish: Almindelig opkastning, kvalme, abdominale smerter, forhøjet blodamylase, dyspepsi, abdominal distention, flatulens
English: All ranges
Danish: Alle intervaller
English: Therefore, darunavir tablets should be taken with cobicistat or ritonavir and with food.
Danish: darunavir skal derfor tages med cobicistat eller ritonavir og med mad.
English: lopinavir AUC ↔ lopinavir Cmin ↑ 13% lopinavir Cmax ↑ 11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% based upon non dose normalised values
Danish: lopinavir AUC ↔ lopinavir Cmin  13% lopinavir Cmax  11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% baseret på ikke-dosisnormaliserede værdier
English: ● 80 ART-experienced HIV-1 infected paediatric patients aged from 6 to 17 years and weighing at least 20 kg who received darunavir tablets with low dose ritonavir twice daily in combination with other antiretroviral agents.
Danish: ● 80 ART-erfarne hiv-1-smittede pædiatriske patienter i alderen 6 til 17 år med en legemsvægt på mindst 20 kg som blev behandlet med darunavir tabletter sammen med lavdosis ritonavir to gange dagligt i kombination med andre antiretrovirale lægemidler.
English: - Swallow the tablets with a drink such as water or milk.
Danish: - Slug tabletterne med noget at drikke som f.eks. vand eller mælk.
English: Clinical monitoring is recommended when co-administering duranavir with low dose ritonavir with these analgesics.
Danish: Klinisk monitoring anbefales ved administration af boostet duranavir sammen lavdosis ritonavir med disse analgetika.