FrancophonIA/ELRC3.0 huggingface dataset:
English: The combined use of Rapamune with angiotensin-converting enzyme (ACE) inhibitors (a type of medicine used to lower blood pressure) may result in allergic reactions.
Slovenian: Uporaba zdravila Rapamune sočasno z zaviralci angiotenzinske konvertaze (ACE) (vrsta zdravil, ki se uporablja za zniževanje krvnega tlaka) lahko povzroči alergijske reakcije.
English: If you experience symptoms, such as bruising or rash, changes in your urine, or changes in behaviour, or any others that are serious, unusual or prolonged, contact your doctor.
Slovenian: Če se vam pojavijo simptomi, kot so modrice ali izpuščaj, spremembe urina ali vedenjske spremembe ali kakšni drugi simptomi, ki so resni, nenavadni ali dolgotrajni, obvestite zdravnika.
English: There was no significant between-group difference in this interval in the change in functional residual capacity, 6-minute walk distance, diffusing capacity of the lung for carbon monoxide, or general well-being score in patients with S-LAM.
Slovenian: Med skupinama v tem obdobju ni bilo pomembnih razlik v spremembi funkcionalne rezidualne kapacitete, razdalje med 6-minutnim preizkusom hoje, difuzijske kapacitete pljuč za ogljikov monoksid ali ocene splošnega dobrega počutja pri bolnikih s S-LAM.
English: Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Slovenian: V posamezni razvrstitvi pogostnosti so neželeni učinki navedeni po padajoči resnosti.
English: Sirolimus is extensively metabolised by O-demethylation and/or hydroxylation.
Slovenian: Obširno se presnavlja z O-demetilacijo in/ali hidroksilacijo.
English: Patients with symptomatic ovarian cysts should be referred for further evaluation.
Slovenian: Bolnice s simptomatskimi ovarijskimi cistami je treba nadalje oceniti.
English: Oversuppression of the immune system can also increase susceptibility to infection, including opportunistic infections (bacterial, fungal, viral and protozoal), fatal infections, and sepsis.
Slovenian: Čezmerno zaviranje imunskega sistema lahko poveča tudi dovzetnost za okužbe, vključno z oportunističnimi okužbami (bakterijskimi, glivičnimi, virusnimi in protozojskimi), smrtnimi okužbami in sepso.
English: Coated tablet (tablet).
Slovenian: obložena tableta (tableta)
English: To minimise variability, Rapamune should be taken at the same time in relation to ciclosporin, 4 hours after the ciclosporin dose, and consistently either with or without food (see section 5.2).
Slovenian: Za zmanjšanje variabilnosti naj bolnik jemlje zdravilo Rapamune ob enakem času glede na ciklosporin, 4 ure po odmerku ciklosporina, in vedno bodisi s hrano ali brez nje (glejte poglavje 5.2).
English: Patients who had both antibody-mediated rejection and T-cell-mediated rejection on the same biopsy were counted once for each category.
Slovenian: Bolnike, ki so ob isti biopsiji imeli s protitelesi povezano zavrnitev in z limfociti T povezano zavrnitev, so šteli v vsako kategorijo enkrat.
English: If you miss a dose of Rapamune completely, you should inform your doctor.
Slovenian: Če popolnoma pozabite vzeti posamezen odmerek zdravila Rapamune, morate o tem obvestiti zdravnika.
English: You should see your doctor immediately if you experience symptoms, such as swollen face, tongue and/or back of the mouth (pharynx) and/or difficulties in breathing (angioedema), or a skin condition whereby the skin can peel off (exfoliative dermatitis).
Slovenian: Nemudoma se posvetujte z zdravnikom, če opazite simptome, kot so otekel obraz, jezik in/ali zadnji del ust (žrelo), in/ali oteženo dihanje (angioedem) ali bolezen kože, pri kateri se koža lahko lušči (eksfoliativni dermatitis).
English: Studies demonstrated that its effects are mediated by a mechanism that is different from that of ciclosporin, tacrolimus, and other immunosuppressive agents.
Slovenian: Študije so pokazale, da so ti učinki posledica mehanizma, ki je drugačen kot pri ciklosporinu, takrolimusu in drugih zdravilih za zaviranje imunske odzivnosti.
English: Then you will need to take 2 mg of Rapamune each day, until otherwise directed by your doctor.
Slovenian: Potem boste morali jemati po 2 mg zdravila Rapamune vsak dan, dokler zdravnik ne odloči drugače.
English: No studies on the effects on the ability to drive and use machines have been performed.
Slovenian: Študij o vplivu na sposobnost vožnje in upravljanja strojevi niso izvedli.
English: Other medicines and Rapamune
Slovenian: Druga zdravila in zdravilo Rapamune
English: Rapamune has no known influence on the ability to drive and use machines.
Slovenian: Zdravilo Rapamune nima znanega vpliva na sposobnost vožnje in upravljanja strojev.
English: Rapamune is used in adults to prevent your body from rejecting transplanted kidneys and is normally used with other immunosuppressant medicines called corticosteroids and initially (the first 2 to 3 months) with ciclosporin.
Slovenian: Zdravilo Rapamune se uporablja pri odraslih za preprečevanje zavrnitve presajene ledvice, običajno skupaj z drugimi zdravili za zaviranje imunske odzivnosti, ki se imenujejo kortikosteroidi, in na začetku (prva 2 do 3 mesece) s ciklosporinom.
English: Sirolimus in combination with other immunosuppressive agents has not been extensively investigated.
Slovenian: Sočasna uporaba sirolimusa z drugimi zaviralci imunske odzivnosti ni bila natančneje raziskana.
English: The key inclusion criteria was post-bronchodilator forced expiratory volume in 1 second (FEV1) ≤70% of predicted during the baseline visit.
Slovenian: Ključno vključitveno merilo je bil forsirani izdihani volumen zraka v 1. sekundi (FEV1 - Forced Expiratory Volume in 1 second) po uporabi bronhodilatatorja ≤ 70 % predvidene vrednosti med obiskom ob izhodišču.
English: Safety was assessed in a controlled study involving 89 patients with LAM, of which 81 patients had S-LAM and 42 of whom were treated with Rapamune (see section 5.1).
Slovenian: Varnost so ocenjevali v nadzorovani študiji, v kateri je sodelovalo 89 bolnikov z LAM, od katerih je S-LAM imelo 81 bolnikov in od katerih so jih z zdravilom Rapamune zdravili 42 (glejte poglavje 5.1).
English: Some medicines can interfere with the action of Rapamune and, therefore, dose adjustment of Rapamune may be required.
Slovenian: Nekatera zdravila lahko vplivajo na delovanje zdravila Rapamune, zato bo pri vas morda potrebna prilagoditev odmerka zdravila Rapamune.
English: If you prefer to take Rapamune with food, then you should always take it with food.
Slovenian: Če zdravilo Rapamune rajši jemljete s hrano, ga vedno jemljite s hrano.
English: The use of Rapamune is not recommended in this population.
Slovenian: Uporaba zdravila Rapamune pri tej skupini ni priporočljiva.
English: 30 coated tablets 100 coated tablets
Slovenian: 30 obloženih tablet 100 obloženih tablet
English: Stir vigorously and drink at once.
Slovenian: Dobro premešamo in takoj popijemo.
English: The mean Cmax was decreased by 35%, and mean tmax increased by 82%.
Slovenian: Srednja vrednost Cmax je zmanjšana za približno 35 %, srednja vrednost tmax pa povečana za 82 %.
English: Sirolimus concentrations were measured in concentration-controlled studies of paediatric renal-transplant patients who were also receiving ciclosporin and corticosteroids.
Slovenian: Koncentracije sirolimusa so merili v s koncentracijo nadzorovanih študijah pri pediatričnih bolnikih po presaditvi ledvic, ki so prejemali tudi ciklosporin in kortikosteroide.
English: Before vaccinations, please inform your doctor or pharmacist that you are receiving Rapamune.
Slovenian: Pred cepljenji obvestite zdravnika ali farmacevta, da prejemate zdravilo Rapamune.
English: In the patient stratum with baseline calculated GFR above 40 mL/min, renal function was not improved overall.
Slovenian: V skupini bolnikov z izhodiščno izračunano GFR, večjo od 40 ml/min, se ledvična funkcija na splošno ni izboljšala.
English: In patients for whom ciclosporin withdrawal is either unsuccessful or cannot be attempted, the combination of ciclosporin and Rapamune should not be maintained for more than 3 months post-transplantation.
Slovenian: Pri bolnikih, pri katerih je ukinjanje ciklosporina neuspešno ali ga ni mogoče izvesti, lahko kombinirano zdravljenje z zdravilom Rapamune in ciklosporinom traja največ 3 mesece po presaditvi.
English: Information directly related to the tablet formulation is summarised specifically in the Oral tablet section.
Slovenian: Podatki, ki se nanašajo neposredno na tablete, pa so povzeti v poglavju Peroralne tablete.
English: No dose adjustment is required (see section 5.2).
Slovenian: Okvara ledvic Prilagoditev odmerka ni potrebna (glejte poglavje 5.2).
English: any high blood pressure medicines or medicines for heart problems including nicardipine, verapamil and diltiazem.
Slovenian: katerakoli zdravila za zdravljenje zvišanega krvnega tlaka ali bolezni srca, vključno z nikardipinom, verapamilom in diltiazemom.
English: What you need to know before you take Rapamune
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Rapamune
English: The changes may be related to chronic immunosuppression.
Slovenian: Te spremembe so lahko posledica kroničnega zaviranja imunske odzivnosti.
English: No other liquids, including grapefruit juice, should be used for dilution.
Slovenian: Drugih tekočin, še posebno soka grenivke, ne uporabljajte za razredčenje.
English: Patients initiated on ramipril 10 mg had a higher rate of BCAR (15%) compared to patients initiated on ramipril 5 mg (5%).
Slovenian: Pri bolnikih z začetnim odmerkom ramiprila 10 mg je bil delež tistih z BCAR večji (15 %) kot pri bolnikih z začetnim odmerkom ramiprila 5 mg (5 %).
English: The difference in bioavailability was less marked upon steady-state administration to renal transplant recipients, and therapeutic equivalence has been demonstrated in a randomised study of 477 patients.
Slovenian: Razlika v biološki uporabnosti je pri bolnikih s presajeno ledvico manj izrazita v stanju dinamičnega ravnovesja, terapevtsko ekvivalentnost pa so pokazali v randomizirani študiji pri 477 bolnikih.
English: Most patients were on immunosuppressive regimens, which included Rapamune in combination with other immunosuppressive agents.
Slovenian: Večina bolnikov je bila zdravljenih po imunosupresivnih shemah, ki so vključevale zdravilo Rapamune v kombinaciji z drugimi imunosupresivnimi zdravili.
English: TEXT FOR 60 mL OUTER CARTON (CONTAINING SYRINGES/BOTTLE IN CARTON)
Slovenian: BESEDILO ZA 60 ml ŠKATLO (VSEBUJE BRIZGE/STEKLENICO V ŠKATLI)
English: The safety and efficacy of Rapamune in children and adolescents less than 18 years of age have not been established.
Slovenian: Varnost in učinkovitost zdravila Rapamune pri otrocih in mladostnikih, mlajših od 18 let, nista bili dokazani.
English: 24 hours in the dosing syringe (at room temperature, but not to exceed 25C).
Slovenian: 24 ur v odmerni brizgi (pri sobni temperaturi, vendar ne višji od 25 °C)
English: Currently in clinical practice, sirolimus whole blood concentrations are being measured by both chromatographic and immunoassay methodologies.
Slovenian: Trenutno se v klinični praksi koncentracija sirolimusa v polni krvi meri tako s kromatografskimi kot tudi z imunološkimi metodami.
English: Once Rapamune maintenance dose is adjusted, patients should continue on the new maintenance dose for at least 7 to 14 days before further dosage adjustment with concentration monitoring.
Slovenian: Po prilagoditvi vzdrževalnega odmerka zdravila Rapamune morajo bolniki novi vzdrževalni odmerek jemati vsaj 7 do 14 dni pred nadaljnjim prilagajanjem odmerka, pri čemer je treba spremljati koncentracijo zdravila.
English: Your doctor will perform tests to monitor the levels of Rapamune in your blood.
Slovenian: Zdravnik bo z laboratorijskimi preiskavami spremljal raven zdravila Rapamune v vaši krvi.
English: So if you are taking Rapamune, you may therefore catch more infections than usual, such as infections of the skin, mouth, stomach and intestines, lungs and urinary tract (see list below).
Slovenian: Če jemljete zdravilo Rapamune, boste lahko zato dobili več okužb kot ponavadi, na primer okužbe kože, ust, želodca in črevesa, pljuč in sečil (glejte seznam v nadaljevanju).
English: There was a higher rate of serious adverse events, including pneumonia, acute rejection, graft loss and death, in this sirolimus treatment arm (n=60, median time post-transplant 36 months).
Slovenian: Delež resnih neželenih učinkov, vključno s pljučnico, akutno zavrnitvijo, izgubo presadka in smrtjo, je bil namreč v tej podskupini, zdravljeni s sirolimusom, večji (n = 60, mediani čas po presaditvi je 36 mesecev).
English: Multiples of the 0.5 mg tablets should therefore not be used as a substitute for other tablet strengths.
Slovenian: Zato se več 0,5 mg tablet ne sme uporabljati za nadomeščanje drugih jakosti tablet.
English: It is recommended that Rapamune be administered 4 hours after ciclosporin (microemulsion).
Slovenian: Priporočljivo je, da zdravilo Rapamune damo 4 ure po ciklosporinu (mikroemulzija).
English: If it is necessary to carry your medication with you, fill the dosing syringe to the appropriate mark and place a cap securely on it - the cap should snap into place.
Slovenian: Če morate zdravilo vzeti s seboj, napolnite brizgo do predpisane oznake in nanjo namestite zaščitni pokrovček - pokrovček se zaskoči na svoje mesto.
English: The rate of death in the sirolimus conversion group was higher than the CNI continuation group, although the rates were not significantly different.
Slovenian: Stopnja smrtnosti v skupini s prehodom na sirolimus je bila večja kot v skupini, ki je nadaljevala s CNI, vendar razlika ni bila statistično pomembna.
English: Loss of TSC gene function activates the mTOR signaling pathway, resulting in cellular proliferation and release of lymphangiogenic growth factors.
Slovenian: Izguba funkcije gena za KTS aktivira signalno pot mTOR, kar povzroči proliferacijo celic in sproščanje limfangiogenih rastnih dejavnikov.
English: Once in the syringe the medication may be kept at room temperature (not exceeding 25C) or refrigerated and should be used within 24 hours.
Slovenian: Zdravilo v odmerni brizgi lahko shranjujte pri sobni temperaturi (ne nad 25 C) ali v hladilniku in ga morate porabiti v 24 urah.
English: In mouse, chronic ulcerative skin lesions were increased.
Slovenian: Pri miših so opazili večjo pogostnost kroničnih ulceroznih lezij na koži.
English: Optimally, adjustments in Rapamune dose should be based on more than a single trough level obtained more than 5 days after a previous dosing change.
Slovenian: Optimalno je, da prilagoditve odmerka zdravila Rapamune temeljijo na več kot eni najmanjši koncentraciji v stanju dinamičnega ravnovesja, ugotovljeni več kot 5 dni po predhodni spremembi odmerjanja.
English: LAM involves lung tissue infiltration with smooth muscle-like cells that harbour inactivating mutations of the tuberous sclerosis complex (TSC) gene (LAM cells).
Slovenian: LAM vključuje infiltracijo pljučnega tkiva s celicami, podobnimi celicam gladkih mišic, v katerih so prisotne inaktivirajoče mutacije gena za kompleks tuberozne skleroze (KTS) (celice LAM).
English: The simultaneous oral administration of 10 mg of Rapamune oral solution and 120 mg of diltiazem significantly affected the bioavailability of sirolimus.
Slovenian: Sočasna uporaba 10 mg peroralne raztopine zdravila Rapamune in 120 mg diltiazema je bistveno spremenila biološko uporabnost sirolimusa.
English: Withdraw the exact amount of Rapamune oral solution as prescribed by your doctor by gently pulling out the plunger of the dosing syringe until the level of the oral solution is even with the appropriate mark on the dosing syringe.
Slovenian: Odvzemite točno tako količino zdravila Rapamune peroralne raztopine, kot vam jo je predpisal zdravnik, tako da počasi izvlečete bat iz odmerne brizge, dokler nivo peroralne raztopine ni poravnan z želeno oznako na odmerni brizgi.
English: Since half-life is prolonged in these patients, therapeutic monitoring of the medicinal product after a loading dose or a change of dose should be performed for a prolonged period of time until stable concentrations are reached (see sections 4.2 and 5.2).
Slovenian: Ker je razpolovni čas pri teh bolnikih podaljšan, je po polnilnem odmerku ali spremembi odmerka potrebno dolgotrajno terapevtsko spremljanje koncentracije zdravila, dokler niso dosežene stabilne koncentracije (glejte poglavji 4.2 in
English: Please inform your doctor if you are taking medicines to lower your blood fats.
Slovenian: Obvestite zdravnika, če jemljete zdravila za zniževanje ravni maščob v krvi.
English: anti-epileptic medicines including carbamazepine, phenobarbital, phenytoin.
Slovenian: zdravila za zdravljenje epilepsije, vključno s karbamazepinom, fenobarbitalom, fenitoinom.
English: At 48 months, there was a statistically significant difference in graft survival in favour of the Rapamune following ciclosporin elimination group compared to the Rapamune with ciclosporin therapy group (including and excluding loss to follow-up).
Slovenian: Po 48 mesecih je bila razlika v preživetju presadka statistično pomembna v korist skupine z zdravilom Rapamune po ukinitvi ciklosporina v primerjavi s skupino, ki se je zdravila z zdravilom Rapamune in ciklosporinom (ne glede na vključenost ali izključenost bolnikov, izgubljenih za spremljanje).
English: In rat, testicular interstitial cell adenomas were likely indicative of a species-dependent response to lutenising hormone levels and are usually considered of limited clinical relevance.
Slovenian: Pri podganah so intersticijski adenomi testisov zelo verjetno posledica od vrste odvisnega odgovora na ravni luteinizirajočega hormona in običajno nimajo večjega kliničnega pomena.
English: After a single dose of [14C] sirolimus in healthy volunteers, the majority (91.1%) of radioactivity was recovered from the faeces, and only a minor amount (2.2%) was excreted in urine.
Slovenian: C označenega sirolimusa pri zdravih prostovoljcih so večino radioaktivnosti (91,1 %) izmerili v blatu in le manjšo količino (2,2 %) v urinu.
English: For patients with S-LAM, the initial Rapamune dose should be 2 mg/day.
Slovenian: Pri bolnikih s S-LAM mora biti začetni odmerek zdravila Rapamune 2 mg/dan.
English: Uncommon (≥1/1,000 to
Slovenian: Občasni (≥ 1/1.000 do
English: You may have been instructed to take your Rapamune oral solution at a particular time of day.
Slovenian: Morda so vam svetovali, da jemljete zdravilo Rapamune peroralno raztopino ob točno določenem času.
English: Nephrotic syndrome (see section 4.4); Focal segmental glomerulosclerosis*
Slovenian: Bolezni sečil proteinurija nefrotski sindrom (glejte poglavje 4.4), fokalna segmentna glomeruloskleroz a*
English: The mean calculated glomerular filtration rate (GFR) at 12, 24, 36, 48 and 60 months was significantly higher for patients receiving Rapamune following ciclosporin elimination than for those in the Rapamune with ciclosporin therapy group.
Slovenian: Povprečna izračunana hitrost glomerulne filtracije (GFR) pri 12, 24, 36, 48 in 60 mesecih je bila pri bolnikih, ki so prejemali zdravilo Rapamune po ukinitvi ciklosporina pomembno večja kot pri tistih, ki so se zdravili z zdravilom Rapamune in ciklosporinom.
English: Rapamune is indicated for the prophylaxis of organ rejection in adult patients at low to moderate immunological risk receiving a renal transplant.
Slovenian: Zdravilo Rapamune je indicirano za preprečevanje zavrnitve organa pri odraslih bolnikih z nizkim do zmernim imunološkim tveganjem pri presaditvi ledvice.
English: After dilution, the preparation should be used immediately.
Slovenian: Po redčenju pripravek uporabite takoj.
English: In two clinical studies in de novo liver transplant patients, the use of sirolimus plus ciclosporin or tacrolimus was associated with an increase in hepatic artery thrombosis, mostly leading to graft loss or death.
Slovenian: V dveh kliničnih študijah pri bolnikih s presadki jeter de novo je bila uporaba sirolimusa s ciklosporinom ali takrolimusom povezana s porastom tromboze jetrne arterije, ki je večinoma vodila v izgubo presadka ali smrt.
English: If you take more Rapamune than you should
Slovenian: Če ste vzeli večji odmerek zdravila Rapamune, kot bi smeli
English: Store in the original bottle in order to protect from light.
Slovenian: Shranjujte v originalni steklenici za zagotovitev zaščite pred svetlobo.
English: This medicine contains approximately 350 mg propylene glycol (E1520) in each mL.
Slovenian: To zdravilo vsebuje približno 350 mg propilenglikola (E1520) na 1 ml.
English: Experimental evidence suggests that sirolimus binds to the specific cytosolic protein FKPB-12, and that the FKPB 12-sirolimus complex inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a critical kinase for cell cycle progression.
Slovenian: Eksperimentalni dokazi kažejo, da se sirolimus veže na specifično beljakovino FKPB-12 v citosolu in da nastali kompleks sirolimus-FKPB-12 zavira aktivacijo tarče rapamicina pri sesalcih (mTOR mammalian Target of Rapamycin), kinaze, ki je ključna za nadaljevanje celičnega cikla pri sesalcih.
English: In animals, sirolimus has a direct effect on T- and B-cell activation, suppressing immune-mediated reactions, such as allograft rejection.
Slovenian: Pri živalih sirolimus deluje neposredno na aktivacijo limfocitov T in B in tako zavira imunsko posredovane reakcije, kot je zavrnitev alogenega presadka.
English: If bubbles form in the oral solution in the dosing syringe during withdrawal, empty the Rapamune solution back into the bottle and repeat the withdrawal procedure.
Slovenian: Če se med odvzemom raztopine v peroralni raztopini v odmerni brizgi pojavijo mehurčki, izpraznite raztopino nazaj v steklenico in postopek ponovite.
English: Although sirolimus inhibits human liver microsomal cytochrome P450 CYP2C9, CYP2C19, CYP2D6, and CYP3A4/5 in vitro, the active substance is not expected to inhibit the activity of these isozymes in vivo since the sirolimus concentrations necessary to produce inhibition are much higher than those observed in patients receiving therapeutic doses of Rapamune.
Slovenian: V in vitro poskusih sirolimus zavira humani jetrni mikrosomski citokrom P450 CYP2C9, CYP2C19, CYP2D6 in CYP3A4/5, vendar ni pričakovati, da bi učinkovina zavirala aktivnost teh izoencimov tudi in vivo, saj so koncentracije sirolimusa, potrebne za inhibicijo, mnogo večje od tistih, ki jih izmerijo pri bolnikih, ki prejemajo terapevtske odmerke zdravila Rapamune.
English: When given 2 hours before CsA administration, sirolimus Cmax and AUC were not affected.
Slovenian: Uporaba sirolimusa 2 uri pred uporabo CsA ni vplivala na vrednosti Cmax in AUC sirolimusa.
English: It is not necessary to modify the Rapamune loading dose.
Slovenian: Polnilnega odmerka ni treba prilagoditi.
English: The blood to plasma ratio (B/P) of 36 indicates that sirolimus is extensively partitioned into formed blood elements.
Slovenian: Razmerje koncentracij sirolimusa v krvi in plazmi (B/P - Blood to Plasma ratio) je 36, kar kaže, da sirolimus obširno prehaja v krvne celice.
English: This amount of alcohol may be harmful for those suffering from alcoholism as well as for pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease, or epilepsy.
Slovenian: Ta odmerek alkohola bi utegnil škodovati alkoholikom, pa tudi nosečnicam ali doječim materam, otrokom in skupinam z velikim tveganjem, kot so bolniki z boleznijo jeter ali epilepsijo.
English: Rapamune oral solution contains polysorbate-80, which is known to increase the rate of di-(2-ethylhexyl)phthalate (DEHP) extraction from polyvinyl chloride (PVC).
Slovenian: Zdravilo Rapamune peroralna raztopina vsebuje polisorbat 80, za katerega je znano, da poveča izločanje di-(2-etilheksil)ftalata (DEHP) iz polivinil klorida (PVC).
English: Rapamune is for oral use only.
Slovenian: Zdravilo Rapamune je samo za peroralno uporabo.
English: Sirolimus administered concomitantly (5 mg), and at 2 hours (5 mg) and 4 hours (10 mg) after CsA (300 mg), resulted in increased sirolimus AUC by approximately 183%, 141% and 80%, respectively.
Slovenian: Uporaba sirolimusa sočasno s CsA (5 mg), 2 uri (5 mg) ali 4 ure (10 mg) po dajanju CsA (300 mg), je povečala vrednost AUC sirolimusa za približno 183 %, 141 % oziroma 80 %.