FrancophonIA/ELRC3.0 huggingface dataset:
English: Inflammation of the salivary gland, skin and lip cancer (non-melanoma skin cancer), decreases in the number (or even lack) of cells in the blood, including low red and white blood cell count, serious allergic reactions (e.g. hypersensitivity, anaphylactic reaction), decreased or loss of appetite, restlessness, light-headedness, blurred or yellowing of vision, decrease in vision and eye pain (possible signs of acute myopia or acute-angle closure glaucoma), inflammation of blood vessels (vasculitis necrotising), inflamed pancreas, upset stomach, yellowing of the skin or eyes (jaundice), lupus-like syndrome (a condition mimicking a disease called systemic lupus erythematosus where the body's immune system attacks the body); skin disorders such as inflamed blood vessels in the skin, increased sensitivity to sunlight, rash, redness of the skin, blistering of the lips, eyes or mouth, skin peeling, fever (possible signs of erythema multiforme), weakness, kidney inflammation or impaired kidney function, glucose in the urine (glycosuria), fever, impaired electrolyte balance, high blood cholesterol levels, decreased blood volume, increased blood levels of glucose, difficulties in controlling blood/ urine levels of glucose in patients with a diagnosis of diabetes mellitus, or fat in the blood.
Croatian: Upala žlijezda slinovnica, rak kože i usana (nemelanomski rak kože), smanjenje broja (ili čak nedostatak) stanica u krvi, uključujući niske vrijednosti crvenih i bijelih krvnih stanica, ozbiljne alergijske reakcije (npr. preosjetljivost, anfilaktička reakcija), smanjeni ili gubitak apetita, nemir, ošamućenost, zamućeni vid ili žutilo pred očima, smanjenje vida i bol u očima (mogući znakovi akutne miopije i akutnog glaukoma zatvorenog kuta), upala krvnih žila (nekrotizirajući vaskulitis), upala gušterače (pankreatitis), nadražen želudac, žutilo kože ili bjeloočnica (žutica), sindrom sličan lupusu (stanje koje oponaša bolest koja se naziva sistemski lupus eritematozus pri kojem imunološki sustav tijela napada tijelo), poremećaji kože kao što je upala krvnih žila kože, povećana osjetljivost na sunčevu svjetlost, osip, crvenilo kože, mjehurići na usnama, očima ili u ustima, ljuštenje kože, vrućica (mogući znakovi multiformnog eritema), slabost, upala bubrega ili oštećenje bubrežne funkcije, glukoza u urinu (glikozurija), vrućica, poremećena ravnoteža elektrolita, visoke vrijednosti kolesterola u krvi, smanjeni volumen krvi, porast razine glukoze u krvi, poteškoće u kontroliranju razine glukoze u krvi/urinu kod bolesnika s dijagnozom šećerne bolesti, ili masnoća u krvi.
English: NAME OF THE MEDICINAL PRODUCT MicardisPlus 40 mg/12.5 mg tablets
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET MicardisPlus 40 mg/12,5 mg tablete
English: Decreased blood potassium levels, anxiety, fainting (syncope), sensation of tingling, pins and needles (paraesthesia), feeling of spinning (vertigo), fast heart beat (tachycardia), heart rhythm disorders, low blood pressure, a sudden fall in blood pressure when you stand up, shortness of breath (dyspnoea), diarrhoea, dry mouth; flatulence, back pain, muscle spasm, muscle pain, erectile dysfunction (inability to get or keep an erection), chest pain, increased blood uric acid levels.
Croatian: Snižene vrijednosti kalija u krvi, tjeskoba, nesvjestica (sinkopa), osjećaj trnaca, bockanja i žarenja (parestezija), osjećaj vrtnje (vrtoglavica), brzi otkucaji srca (tahikardija), poremećaji srčanog ritma, niski krvni tlak, iznenadni pad krvnog tlaka prilikom ustajanja, nedostatak zraka (zaduha), proljev, suha usta, vjetrovi, bol u leđima, grčevi mišića, bolovi u mišićima, erektilna disfunkcija (nesposobnost postizanja ili održavanja erekcije), bol u prsnom košu, povišene vrijednosti mokraćne kiseline u krvi.
English: Decreased blood potassium levels, anxiety, fainting (syncope), sensation of tingling, pins and needles (paraesthesia), feeling of spinning (vertigo), fast heart beat (tachycardia), heart rhythm disorders, low blood pressure, a sudden fall in blood pressure when you stand up, shortness of breath (dyspnoea), diarrhoea, dry mouth, flatulence, back pain, muscle spasm, muscle pain, erectile dysfunction (inability to get or keep an erection), chest pain, increased blood uric acid levels.
Croatian: Snižene vrijednosti kalija u krvi, tjeskoba, nesvjestica (sinkopa), osjećaj trnaca, bockanja i žarenja (parestezija), osjećaj vrtnje (vrtoglavica), brzi otkucaji srca (tahikardija), poremećaji srčanog ritma, niski krvni tlak, iznenadni pad krvnog tlaka prilikom ustajanja, nedostatak zraka (zaduha), proljev, suhoća usta, vjetrovi, bol u leđima, grčevi mišića, bolovi u mišićima, erektilna disfunkcija (nesposobnost postizanja ili održavanja erekcije), bol u prsnom košu, povišene vrijednosti mokraćne kiseline u krvi.
English: MicardisPlus 40 mg/12.5 mg tablets telmisartan/hydrochlorothiazide
Croatian: MicardisPlus 40 mg/12,5 mg tablete telmisartan/hidroklorotiazid
English: MicardisPlus 80 mg/12.5 mg tablets telmisartan/hydrochlorothiazide
Croatian: MicardisPlus 80 mg/12,5 mg tablete telmisartan/hidroklorotiazid
English: MicardisPlus 40 mg/12.5 mg tablets
Croatian: MicardisPlus 40 mg/12,5 mg tablete MicardisPlus 80 mg/12,5 mg tablete
English: Date of first authorisation: 9 November 2016
Croatian: Datum prvog odobrenja: 9. studenog 2016.
English: Such changes may in part be linked to disease control and life style.
Croatian: Te promjene mogu djelomično biti povezane s kontrolom bolesti i stilom života.
English: Look out for any symptoms of infection or other symptoms such as:
Croatian: Pazite na sve simptome infekcije ili druge simptome poput:
English: NC = not calculated.
Croatian: NI = nije izračunato
English: Black/African American
Croatian: Crnci/Afroamerikanci Bijelci
English: If you have hepatitis B or C, your doctor will carefully consider the best treatment regimen for you.
Croatian: Ako imate hepatitis B ili C, liječnik će pažljivo razmotriti najbolji režim liječenja za Vas.
English: • difficulty sleeping, abnormal dreams,
Croatian: • poteškoće sa spavanjem, abnormalni snovi
English: • Any signs of inflammation or infection.
Croatian: • Bilo kakvi znakovi upale ili infekcije.
English: You may require blood tests for several months after stopping treatment.
Croatian: Možda ćete morati obavljati krvne pretrage nekoliko mjeseci nakon prestanka liječenja.
English: Tell your doctor if you are taking any of these medicines.
Croatian: Obavijestite svog liječnika ako uzimate bilo koji od tih lijekova.
English: This is to make sure that your medicine is fully effective, and to reduce the risk of developing resistance to the treatment.
Croatian: To je zato da se osigura puna učinkovitost lijeka i smanji rizik od razvoja otpornosti na liječenje.
English: PC: [outer packaging only] SN: [outer packaging only] NN: [outer packaging only]
Croatian: PC: [samo vanjsko pakiranje] SN: [samo vanjsko pakiranje] NN: [samo vanjsko pakiranje]
English: It is thought that these symptoms are due to an improvement in the body's immune response, enabling the body to fight infections that may have been present with no obvious symptoms.
Croatian: Smatra se da ti simptomi nastaju zbog poboljšanja imunološkog odgovora organizma, što tijelu omogućuje da se bori protiv infekcija koje mogu biti prisutne bez vidljivih simptoma.
English: • Provides safety information on adherence, HIV testing, renal, bone and HBV status.
Croatian: • donosi sigurnosne informacije o pridržavanju terapije, testiranju na HIV, bubrežnom, koštanom i HBV statusu.
English: • interleukin-2 (to treat cancer).
Croatian: • interleukin-2 (za liječenje raka)
English: If this applies to you, tell your doctor immediately.
Croatian: Ako se ovo odnosi na Vas, odmah o tome obavijestite liječnika.
English: EU/1/16/1148/001 30 film-coated tablets EU/1/16/1148/002 90 (3x30) film-coated tablets
Croatian: EU/1/16/1148/001 30 filmom obloženih tableta EU/1/16/1148/002 90 (3 x 30) filmom obloženih tableta
English: If you think you may have lactic acidosis, get medical help immediately.
Croatian: Ako mislite da možda imate laktacidozu, odmah potražite liječničku pomoć.
English: TLOVR = Time to Loss of Virologic Response a Van Elteren Test
Croatian: TLOVR = vrijeme do gubitka virološkog odgovora a Van Elterenov test
English: hours to 42,857 (29%) ng·h/ml of tenofovir.
Croatian: 48 sati na 42 857 (29%) ng•h/ml za tenofovir.
English: • Adults: one tablet each day, whenever possible, with food.
Croatian: • Odrasli: jedna tableta svaki dan, kad god je to moguće s hranom.
English: Each bottle contains a silica gel desiccant that must be kept in the bottle to help protect your tablets.
Croatian: U svakoj se boci nalazi sredstvo za sušenje (silika-gel) koje se mora držati u boci radi zaštite tableta.
English: Excipient with known effect: each tablet contains a maximum of 9.53 mg sodium.
Croatian: Pomoćna tvar s poznatim učinkom: jedna tableta sadrži najviše 9,53 mg natrija.
English: Non-clinical data on emtricitabine reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential and toxicity to reproduction and development.
Croatian: Neklinički podaci o emtricitabinu ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti, kancerogenog potencijala, reproduktivne i razvojne toksičnosti.
English: The silica gel desiccant is contained in a separate container and should not be swallowed.
Croatian: Silika-gel se nalazi u posebnom spremniku i ne smije se progutati.
English: If you notice these or any symptoms of inflammation or infection, get medical help immediately.
Croatian: Ako primijetite ove simptome ili bilo koji drugi simptom upale ili infekcije, odmah potražite liječničku pomoć.
English: Autoimmune disorders may occur many months after the start of treatment.
Croatian: Autoimuni poremećaji mogu nastati i više mjeseci nakon početka liječenja.
English: However, as would be expected in this patient population, elevations in AST and ALT occurred more frequently than in the general HIV infected population.
Croatian: No, kao što se u toj populaciji bolesnika moglo očekivati, porast vrijednosti AST-a i ALT-a bio je češći nego u općoj populaciji zaraženoj HIV-om.
English: This medicine is not a cure for HIV infection.
Croatian: Ovaj lijek neće izliječiti HIV-infekciju.
English: If overdose occurs the individual must be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Croatian: U slučaju predoziranja osoba mora biti pod nadzorom zbog znakova toksičnosti (vidjeti dio 4.8) te joj se, prema potrebi, mora pružiti standardno potporno liječenje.
English: • Get tested for other sexually transmitted infections such as syphilis and gonorrhoea.
Croatian: Testirajte se na druge spolno prenosive bolesti kao što su sifilis i gonoreja.
English: • Recommended schedule for monitoring renal function considering the presence or absence of additional risk factors for renal impairment
Croatian: • Preporučuje se raspored praćenja funkcije bubrega s obzirom na prisutnost ili odsutnost dodatnih čimbenika rizika za oštećenje bubrega
English: • Lactic acidosis (excess lactic acid in the blood) is a rare but potentially life-threatening side effect.
Croatian: • Laktacidoza (prekomjerna količina mliječne kiseline u krvi) je rijetka, ali životno ugrožavajuća nuspojava.
English: Both of these active substances are antiretroviral medicines which are used to treat HIV infection.
Croatian: Obje su djelatne tvari antiretrovirusni lijekovi koji se upotrebljavaju za liječenje HIV-infekcije.
English: Contents of the pack:
Croatian: Sadržaj pakiranja:
English: In general, the pharmacokinetics of emtricitabine in infants, children and adolescents (aged 4 months up to 18 years) are similar to those seen in adults.
Croatian: Općenito, farmakokinetika emtricitabina u dojenčadi, djece i adolescenata (u dobi od 4 mjeseca do 18 godina) slična je farmakokinetici koja se opaža u odraslih osoba.
English: Please refer to the patient information leaflets of the other antiretrovirals for guidance on how to take those medicines.
Croatian: Molimo da pročitate upute o lijeku za druge antiretrovirusne lijekove radi smjernica o načinu uzimanja tih lijekova.
English: 35 kg, and who have already been treated with other HIV medicines that are no longer effective or have caused side effects.
Croatian: 18 godina, tjelesne težine najmanje 35 kg te su već liječeni drugim lijekovima za HIV koji više nisu učinkoviti ili su izazvali nuspojave.
English: Tell your doctor if you have had kidney disease, or if tests have shown kidney problems.
Croatian: Obavijestite liječnika ako ste imali bolest bubrega ili ako su pretrage ukazale na probleme s bubrezima.
English: Bone toxicity was diagnosed as osteomalacia (monkeys) and reduced BMD (rats and dogs).
Croatian: Toksičnost za kosti dijagnosticirana je kao osteomalacija (kod majmuna) i sniženi BMD (kod štakora i pasa).
English: If appropriate, resumption of hepatitis B therapy may be warranted.
Croatian: Ako je prikladno. nastavak terapije hepatitisa B može biti opravdan.
English: As a general rule, it is recommended that HIV infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV to the infant.
Croatian: Kao opće pravilo, preporučuje se da žene zaražene HIV-om ni pod kojim okolnostima ne doje svoju dojenčad, kako bi se izbjegao prijenos HIV-a na dojenče.
English: Both emtricitabine and tenofovir have activity that is specific to human immunodeficiency virus (HIV-1 and HIV-2) and hepatitis B virus.
Croatian: I emtricitabin i tenofovir imaju aktivnost koja je specifična za virus humane imunodeficijencije (HIV-1 i HIV-2) i virus hepatitisa B.
English: • rashes (including red spots or blotches sometimes with blistering and swelling of the skin), which may be allergic reactions, itching, changes in skin colour including darkening of the skin in patches,
Croatian: • osipi (uključujući crvene točkice ili mrlje, katkad s pojavom mjehurića i oticanjem kože), koji mogu biti alergijske reakcije, svrbež, promjene boje kože, uključujući tamnjenje dijelova kože
English: Effects on drug levels Mean percent change in AUC, Cmax, Cmin with 90% confidence intervals if available (mechanism)
Croatian: Postotak prosječne promjene AUC, Cmax, Cmin, uz 90% intervale pouzdanosti ukoliko su dostupni (mehanizam)
English: • low white blood cell count (a reduced white blood cell count can make you more prone to infection),
Croatian: • nizak broj bijelih krvnih stanica (zbog smanjenog broja bijelih krvnih stanica možete postati skloniji infekcijama)
English: • Do not share or re-use needles or other injection or drug equipment.
Croatian: Nemojte s drugima dijeliti ili koristiti već upotrijebljene igle ili drugi pribor za injekcije ili ubrizgavanje droge.
English: For lipids, there is in some cases evidence for a treatment effect, while for weight gain there is no strong evidence relating this to any particular treatment.
Croatian: Za lipide u nekim slučajevima postoji dokaz o učinku liječenja, dok za povezanost porasta tjelesne težine s nekim posebnim liječenjem nema čvrstog dokaza.
English: • softening of the bones (with bone pain and sometimes resulting in fractures).
Croatian: • omekšavanje kostiju (uz bol u kostima i ponekad s posljedičnim prijelomom)
English: In individuals without risk factors for renal disease, it is recommended that renal function (creatinine clearance and serum phosphate) is monitored after two to four weeks of use, after three months of use and every three to six months thereafter.
Croatian: U osoba bez čimbenika rizika za bolest bubrega preporučuje se pratiti funkciju bubrega (klirens kreatinina i fosfate u serumu) nakon dva do četiri tjedna primjene, nakon tri mjeseca primjene te nakon toga svakih tri do šest mjeseci.
English: Lactic acidosis occurs more often in women, particularly if they are overweight, and in people with liver disease.
Croatian: Laktacidoza češće nastaje u žena, osobito ako imaju prekomjernu tjelesnu težinu, te u osoba s bolešću jetre.
English: Taking this type of medicine for a long time, taking corticosteroids, drinking alcohol, having a very weak immune system, and being overweight, may be some of the many risk factors for developing this disease.
Croatian: Dugotrajno uzimanje ove vrste lijekova, primjena kortikosteroida, konzumiranje alkohola, jako oslabljen imunološki sustav i prekomjerna tjelesna težina mogu biti neki od mnogobrojnih čimbenika rizika za razvoj ove bolesti.
English: • increased triglycerides (fatty acids), bile or sugar in the blood,
Croatian: • povišene razine triglicerida (masne kiseline), bilirubina ili šećera u krvi
English: • other allergic reactions, such as wheezing, swelling or feeling light-headed.
Croatian: • druge alergijske reakcije, kao što su piskanje pri disanju, oticanje ili ošamućenost
English: 2 Anaemia was common and skin discolouration (increased pigmentation) was very common when emtricitabine was administered to paediatric patients.
Croatian: 2 Anemija je bila česta, a promjena boje kože (povećana pigmentacija) vrlo česta kad se emtricitabin primjenjivao u pedijatrijskih bolesnika.
English: Taking Emtricitabine/Tenofovir disoproxil Zentiva with other medicines that can damage your kidneys: it is especially important to tell your doctor if you are taking any of these medicines, including
Croatian: Uzimanje lijeka Emtricitabine/Tenofovir disoproxil Zentiva s drugim lijekovima koji Vam mogu oštetiti bubrege: osobito je važno da obavijestite liječnika ako uzimate neki od tih lijekova, uključujući:
English: People who are HIV positive can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
Croatian: Osobe koje su HIV-pozitivne mogu prenijeti HIV drugima čak i dok uzimaju ovaj lijek, iako učinkovita antiretrovirusna terapija smanjuje taj rizik.
English: This is partly linked to restored health and life style, and in the case of blood lipids sometimes to the HIV medicines themselves.
Croatian: To je dijelom povezano s poboljšanjem zdravstvenog stanja i stila života, dok je u slučaju lipida u krvi katkad povezano i sa samim lijekovima protiv HIV-a.
English: Pre-exposure prophylaxis (PrEP)
Croatian: Predekspozicijska profilaksa (PrEP)
English: Following oral administration, the elimination half-life of tenofovir is approximately 12 to 18 hours.
Croatian: Nakon peroralne primjene, poluvijek eliminacije tenofovira iznosi približno 12 do 18 sati.
English: • Do not share personal items that can have blood or body fluids on them, such as toothbrushes and razor blades.
Croatian: Nemojte s drugima dijeliti osobne predmete na kojima može biti krvi ili tjelesnih tekućina, kao što su četkice za zube i britvice za brijanje.
English: Wait and take the next dose, preferably with food, at your usual time.
Croatian: Pričekajte pa uzmite sljedeću dozu u uobičajeno vrijeme, po mogućnosti s hranom.
English: Rare angioedema
Croatian: Rijetko angioedem
English: • If you are a woman with HIV it is recommended that you do not breast-feed, to avoid passing the virus to the baby in breast milk.
Croatian: • Ako ste žena zaražena HIV-om, preporučuje se da ne dojite kako ne biste mlijekom prenijeli virus na dojenče.
English: Following intravenous administration the volume of distribution of emtricitabine and tenofovir was approximately 1.4 l/kg and 800 ml/kg, respectively.
Croatian: Nakon intravenske primjene volumen distribucije emtricitabina i tenofovira bio je približno 1,4 l/kg odnosno 800 ml/kg.
English: The primary efficacy endpoint for this study was the achievement and maintenance of confirmed HIV-1 RNA concentrations < 400 copies/ml over 48 weeks.
Croatian: Primarna mjera ishoda za djelotvornost u ovom ispitivanju bila je postizanje i održavanje potvrđene koncentracije HIV-1 RNK < 400 kopija/ml tijekom 48 tjedana.
English: Rare osteomalacia (manifested as bone pain and infrequently contributing to fractures)1,3, myopathy1
Croatian: Rijetko osteomalacija (koja se očituje bolovima u kostima i rijetko pridonosi prijelomima)1,3, miopatija1
English: • non-steroidal anti-inflammatory drugs (NSAIDs, to relieve bone or muscle pains).
Croatian: • nesteroidne protuupalne lijekove (NSAIL, za ublažavanje boli u kostima ili mišićima).
English: In infants and children older than 4 months, the majority of patients taking emtricitabine achieved or maintained complete suppression of plasma HIV-1 RNA through 48 weeks (89% achieved ≤ 400 copies/ml and 77% achieved ≤ 50 copies/mL).
Croatian: U dojenčadi i djece starije od 4 mjeseca, većina bolesnika koji su primali emtricitabin postigla je ili održala potpunu supresiju plazmatske HIV-1 RNK tijekom 48 tjedana (89% postiglo je ≤ 400 kopija/ml, a 77% postiglo je ≤ 50 kopija/ml).
English: The frequency of the following side effects is not known.
Croatian: Učestalost sljedećih nuspojava nije poznata:
English: In children whose mothers took NRTIs during pregnancy, the benefit from the protection against HIV outweighed the risk of side effects.
Croatian: djece čije su majke tijekom trudnoće uzimale NRTI-jeve prevagnula je korist od zaštite protiv HIV-a u odnosu na rizike od nuspojava.
English: Precautions to prevent transmission of HIV by infected individuals should be taken in accordance with national guidelines.
Croatian: Potrebno je primijeniti mjere opreza za sprječavanje prijenosa HIV-a sa zaraženih osoba u skladu s nacionalnim smjernicama.
English: • problems with digestion resulting in discomfort after meals, feeling bloated, flatulence,
Croatian: • problemi s probavom koji dovode do nelagode nakon obroka, osjećaj napuhnutosti, vjetrovi
English: Metabolism and nutrition disorders Very common hypophosphataemia1
Croatian: Poremećaji metabolizma i prehrane Vrlo često hipofosfatemija1
English: Damage to kidney tubule cells may be associated with breakdown of muscle, softening of the bones (with bone pain and sometimes resulting in fractures), muscle pain, muscle weakness and decreases in potassium or phosphate in the blood.
Croatian: Oštećenje stanica bubrežnih kanalića može biti povezano s razgradnjom mišića, omekšavanjem kosti (uz bol u kostima i ponekad s posljedičnim prijelomima), bolom u mišićima, slabošću mišića i sniženjem razine kalija ili fosfata u krvi.
English: While effective viral suppression with antiretroviral therapy has been proven to substantially reduce the risk of sexual transmission, a residual risk cannot be excluded.
Croatian: Prijenos HIV-a Iako je dokazano da učinkovita supresija virusa antiretrovirusnom terapijom znatno smanjuje rizik od prijenosa spolnim putem, ne može se isključiti rezidualni rizik.
English: The difference in the proportion of patients who maintained < 400 copies/ml at week 48 was mainly influenced by the higher number of discontinuations in the tenofovir disoproxil treatment group.
Croatian: Razlika u udjelu bolesnika koji su održali < 400 kopija/ml u 48. tjednu uglavnom je posljedica većeg broja odustajanja u skupini koja je dobivala tenofovirdizoproksil.
English: If you are taking another antiviral medicine called a protease inhibitor to treat HIV, your doctor may order blood tests to closely monitor your kidney function.
Croatian: Ako za liječenje HIV infekcije uzimate još jedan antivirusni lijek koji se zove inhibitor proteaze, Vaš liječnik može zatražiti krvne pretrage kako bi pažljivo pratio funkciju bubrega.
English: Tenofovir is primarily excreted by the kidney by both filtration and an active tubular transport system with approximately 70 - 80% of the dose excreted unchanged in urine following intravenous administration.
Croatian: Tenofovir se prvenstveno izlučuje preko bubrega, filtracijom i aktivnim tubularnim transportnim sustavom, pri čemu se oko 70-80% doze izlučuje u mokraći u nepromijenjenom obliku nakon intravenske primjene.
English: Open bottles by pressing the child proof cap down and turning it counter-clock wise.
Croatian: Otvorite bocu tako da pritisnete zatvarač siguran za djecu i okrenete ga u smjeru suprotnom od kazaljke na satu.