FrancophonIA/ELRC3.0 huggingface dataset:
English: Concomitant use of thiazide type diuretics may lead to hypercalcaemia in patients pre-disposed for hypercalcaemia (e.g. hyperparathyroidism, malignancy or vitamin-D-mediated conditions) by increasing tubular calcium reabsorption.
Croatian: Istodobna primjena diuretika tiazidnog tipa može dovesti do hiperkalcijemije u bolesnika predisponiranih za hiperkalcijemiju (npr. hiperparatiroidizam, malignom ili stanja posredovana vitaminom D) povećanjem tubularne reapsorpcije kalcija.
English: These include potassium supplements or salt substitutes containing potassium, potassium-sparing medicines and heparin;
Croatian: To uključuje nadomjesci kalija ili zamjene za sol koje sadrže kalij, lijekove koji štede kalij i heparin;
English: Hydrochlorothiazide belongs to a group of substances called “thiazide diuretics”.
Croatian: Hidroklorotiazid pripada skupini tvari koje se nazivaju „tiazidni diuretici“.
English: • abnormal red blood cell test
Croatian: • poremećen nalaz crvenih krvnih stanica
English: Thiazide diuretics, including hydrochlorothiazide, may alter glucose tolerance and raise serum levels of cholesterol, triglycerides and uric acid.
Croatian: Tiazidni diuretici, uključujući hidroklorotiazid, mogu promijeniti toleranciju glukoze i povisiti razine kolesterola, triglicerida i mokraćne kiseline u serumu.
English: Dafiro HCT tablets contain three substances called amlodipine, valsartan and hydrochlorothiazide.
Croatian: Dafiro HCT tablete sadrže tri djelatne tvari koje se zovu amlodipin, valsartan i hidroklorotiazid.
English: The safety of Dafiro HCT has been evaluated at its maximum dose of 10 mg/320 mg/25 mg in one controlled short-term (8 weeks) clinical study with 2,271 patients, 582 of whom received valsartan in combination with amlodipine and hydrochlorothiazide.
Croatian: Sigurnost primjene Dafiro HCT-a je ispitivana u njegovoj najvišoj dozi od 10 mg/320 mg/25 mg u jednom kontroliranom kratkotrajnom (8 tjedana) kliničkom ispitivanju s 2271 bolesnikom, od kojih je 582 primalo valsartan u kombinaciji s amlodipinom i hidroklorotiazidom.
English: Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (heparin, etc.) is not recommended.
Croatian: Istodobna primjena s nadomjescima kalija, diureticima koji štede kalij, zamjenama za sol koje sadrže kalij ili drugim lijekovima koji mogu povisiti razine kalija (heparin, itd.) se ne preporučuje.
English: If you get these symptoms, stop taking Dafiro HCT and contact your doctor straight away.
Croatian: Ako dobijete ove simptome, prekinite uzimati Dafiro HCT i odmah se javite svom liječniku.
English: The side effects reported with Dafiro HCT or one of its three active substances (amlodipine, valsartan and hydrochlorothiazide) are listed below and may occur with the use of Dafiro HCT.
Croatian: Nuspojave prijavljene za Dafiro HCT ili za jednu od tri komponente (amlodipin, valsartan i hidroklorotiazid) navedene su niže i mogu se javiti kod uzimanja Dafiro HCT.
English: A randomised double-blind morbidity-mortality study called the Antihypertensive and LipidLowering treatment to prevent Heart Attack Trial (ALLHAT) was performed to compare newer therapies: amlodipine 2.5-10 mg/day (calcium channel blocker) or lisinopril 10-40 mg/day (ACEinhibitor) as first-line therapies to that of the thiazide-diuretic, chlorthalidone 12.5-25 mg/day in mild to moderate hypertension.
Croatian: Randomizirano dvostruko slijepo ispitivanje pobola i smrtnosti pod nazivom Antihipertenzivno i antilipidno liječenje u cilju sprječavanja srčanog udara (ALLHAT) provedeno je da bi se usporedile novije terapije: amlodipin 2,5-10 mg/dan (blokator kalcijevih kanala) ili lizinopril 10-40 mg/dan (ACE-inhibitor) kao terapije prve linije s terapijom tiazidnim diuretikom, klortalidonom 12,5-25 mg/dan u blagoj do umjerenoj hipertenziji.
English: • fever, sore throat or mouth ulcers, more frequent infections (lack or low level of white blood cells)
Croatian: • vrućica, grlobolja ili čirevi u ustima, učestalije infekcije (manjak ili niska razina bijelih krvnih stanica)
English: Amlodipine, valsartan and hydrochlorothiazide exhibit linear pharmacokinetics.
Croatian: Amlodipin, valsartan i hidroklorotiazid pokazuju linearnu farmakokinetiku.
English: Amlodipine is unlikely to be removed by haemodialysis.
Croatian: Amlodipin se ne može ukloniti hemodijalizom.
English: Thiazide diuretics may precipitate azotaemia in patients with chronic kidney disease.
Croatian: Tiazidski diuretici mogu uzrokovati azotemiju u bolesnika s kroničnom bubrežnom bolešću.
English: Following oral administration of Dafiro HCT in normal healthy adults, peak plasma concentrations of amlodipine, valsartan and hydrochlorothiazide are reached in 6-8 hours, 3 hours, and 2 hours, respectively.
Croatian: Nakon peroralne primjene Dafiro HCT-a u normalnih, zdravih odraslih osoba, vršne koncentracije amlodipina u plazmi postižu se za 6-8 sati, valsartana unutar 3 sata, a hidroklorotiazida unutar 2 sata.
English: Multipack: 280 (20 packs of 14) film-coated tablets.
Croatian: Višestruko pakiranje: 280 (20 pakiranja od 14) filmom obloženih tableta.
English: • liver disorders which can occur together with yellow skin and eyes, or dark-coloured urine
Croatian: • poremećaj jetre koji se može javiti zajedno s žutom kožom i očima ili tamno obojenom mokraćom (hemolitička anemija)
English: In the presence of renal impairment, mean peak plasma levels and AUC values of hydrochlorothiazide are increased and the urinary excretion rate is reduced.
Croatian: Kad postoji oštećenje bubrega, povećavaju se srednja vrijednost vršnih razina u plazmi i AUC vrijednosti hidroklorotiazida, a smanjuje se brzina izlučivanja mokraćom.
English: Valsartan is an orally active, potent and specific angiotensin II receptor antagonist.
Croatian: Valsartan je lijek djelatan pri peroralnoj primjeni, koji je potentan i specifičan antagonist receptora angiotenzina II.
English: Dafiro HCT is contraindicated in patients with hypercalcaemia and should only be used after correction of any pre-existing hypercalcaemia.
Croatian: Dafiro HCT je kontraindiciran u bolesnika s hiperkalcijemijom te se smije primjenjivati tek nakon korekcije eventualne, već postojeće hiperkalcijemije.
English: Patients should be re-hydrated before the administration.
Croatian: Bolesnike je prije primjene potrebno rehidrirati.
English: Severe renal impairment (GFR <30 ml/min/1.73 m2), anuria and patients undergoing dialysis.
Croatian: Teško oštećenje bubrega (GFR <30 ml/min/1,73 m2), anurija i bolesnici na dijalizi.
English: Administration of thiazide diuretics, including hydrochlorothiazide, with vitamin D or with calcium salts may potentiate the rise in serum calcium.
Croatian: Primjena tiazidnih diuretika, uključujući hidroklorotiazid, s vitaminom D ili s kalcijevim solima može potencirati povišenje kalcija u serumu.
English: When switching eligible elderly hypertensive patients (see section 4.1) to Dafiro HCT, the lowest available dose of the amlodipine component should be used.
Croatian: Prilikom prebacivanja starijih hipertenzivnih bolesnika koji ispunjavaju uvjete za liječenje (vidjeti dio 4.1) na Dafiro HCT, treba se koristiti najniža dostupna doza amlodipina kao komponente.
English: Hydrochlorothiazide may raise the serum uric acid level due to reduced clearance of uric acid and may cause or exacerbate hyperuricaemia as well as precipitate gout in susceptible patients.
Croatian: Hidroklorotiazid može povisiti razinu mokraćne kiseline u serumu zbog sniženog klirensa mokraćne kiseline te može uzrokovati ili pogoršati hiperuricemiju, kao i potaknuti pojavu gihta u podložnih bolesnika.
English: • sleep disturbances
Croatian: • poremećaji spavanja
English: Due to the hydrochlorothiazide component, Dafiro HCT is contraindicated for use in patients with anuria (see section 4.3) and in patients with severe renal impairment (glomerular filtration rate (GFR) <30 ml/min/1.73 m2) (see sections 4.3, 4.4 and 5.2).
Croatian: Zbog hidroklorotiazidne komponente, primjena Dafiro HCT je kontraindicirana u bolesnika s anurijom (vidjeti dio 4.3) i u bolesnika s teškim oštećenjem bubrega (brzina glomerularne filtracije (GFR) <30 ml/min/1,73 m2) (vidjeti dijelove 4.3, 4.4 i 5.2).
English: if the level of calcium in your blood is too high despite treatment to reduce the calcium levels in your blood.
Croatian: ako je razina kalcija u Vašoj krvi previsoka unatoč liječenju kako bi se smanjila razina kalcija u Vašoj krvi. ako imate giht (kristali mokraćne kiseline u zglobovima).
English: The degree to which hydrochlorothiazide is removed by haemodialysis has not been established.
Croatian: Stupanj uklanjanja hidroklorotiazida hemodijalizom nije utvrđen.
English: Thiazide diuretics can precipitate new onset hypokalaemia or exacerbate preexisting hypokalaemia.
Croatian: Tiazidski diuretici mogu uzrokovati novi nastup hipokalijemije ili pogoršati već postojeću hipokalijemiju.
English: The use of Dafiro HCT during breastfeeding is not recommended.
Croatian: Primjena Dafiro HCT-a tijekom dojenja se ne preporučuje.
English: In patients with mild to moderate renal impairment, a 3-fold increase in hydrochlorothiazide AUC has been observed.
Croatian: U bolesnika s blagim do umjerenim oštećenjem bubrega opaženo je 3-puta povećanje AUC-a hidroklorotiazida.
English: If you have accidentally taken too many Dafiro HCT tablets, talk to a doctor immediately.You may require medical attention.
Croatian: Ako ste slučajno uzeli previše tableta Dafiro HCT-a, odmah se obratite liječniku.
English: • reduced appetite
Croatian: • smanjen apetit
English: • medicines for the treatment of diabetes (oral agents such as metformin or insulins);
Croatian: • lijekovima za liječenje šećerne bolesti (oralni lijekovi, poput metformina, ili inzulini);
English: The major symptom of overdose with valsartan is possibly pronounced hypotension with dizziness.
Croatian: Glavni simptom predoziranja valsartanom je izrazita hipotenzija s omaglicom.
English: Treatment with hydrochlorothiazide should only be started after correction of pre-existing hyponatraemia.
Croatian: Liječenje hidroklorotiazidom smije se započeti tek nakon korekcije već postojeće hiponatrijemije.
English: Serum electrolyte changes
Croatian: Promjene elektrolita u serumu
English: Concomitant use of thiazide diuretics, including hydrochlorothiazide, with beta blockers may increase the risk of hyperglycaemia.
Croatian: Istodobna primjena tiazidnih diuretika, uključujući hidroklorotiazid, s beta blokatorima može povećati rizik od hiperglikemije.
English: if you have kidney problems, have had a kidney transplant or if you had been told that you have a narrowing of your kidney arteries.
Croatian: ako imate probleme s bubrezima, ako Vam je presađen bubreg ili ako Vam je rečeno da imate suženje bubrežnih arterija. ako imate probleme s jetrom.
English: • medicines that may induce “torsades de pointes” (irregular heart beat), such as antiarrhythmics
Croatian: • lijekovima koji mogu izazvati „torsades de pointes“ (nepravilni otkucaji srca), kao što su antiaritmici (lijekovi koji se koriste za liječenje srčanih poremećaja) i neki antipsihotici;
English: Thiazide diuretics, including hydrochlorothiazide, have been reported to exacerbate or activate systemic lupus erythematosus.
Croatian: Prijavljeno je da tiazidni diuretici, uključujući hidroklorotiazid, pogoršavaju ili aktiviraju sistemski eritematozni lupus.
English: If a medicinal product that affects potassium levels is considered necessary in combination with valsartan, frequent monitoring of potassium plasma levels is advised.
Croatian: Ako se u kombinaciji s valsartanom smatra nužnim primijeniti lijek koji utječe na razine kalija, savjetuje se često praćenje razina kalija u plazmi.
English: • increase of creatinine in the blood
Croatian: • povišenje kreatinina u krvi
English: When switching eligible hypertensive patients (see section 4.1) with hepatic impairment to Dafiro HCT, the lowest available dose of the amlodipine component should be used.
Croatian: Prilikom prebacivanja hipertenzivnih bolesnika koji ispunjavaju uvjete za liječenje (vidjeti dio 4.1) s oštećenjem jetre na Dafiro HCT, treba se koristiti najniža dostupna doza amlodipina kao komponente.
English: • increase of urea nitrogen, creatinine and uric acid in the blood
Croatian: • povišenje ureje, kreatinina i mokraćne kiseline u krvi
English: Urticaria and other forms of rash
Croatian: Urtikarija i druge vrste osipa
English: • loss of pain sensation
Croatian: • gubitak osjećaja boli
English: The combination resulted in expected reduction of red blood cell mass (erythrocytes, haemoglobin, haematocrit, and reticulocytes), increase in serum urea, increase in serum creatinine, increase in serum potassium, juxtaglomerular (JG) hyperplasia in the kidney and focal erosions in the glandular stomach in rats.
Croatian: Primjena ove kombinacije u štakora je rezultirala očekivanim smanjenjem mase crvenih krvnih stanica (eritrociti, hemoglobin, hematokrit i retikulociti), povišenjem uree u serumu, povišenjem kreatinina u serumu, povišenjem kalija u serumu, hiperplazijom jukstaglomerularnih (JG) stanica bubrega i žarišnim erozijama žljezdanog tkiva sluznice želuca.
English: There is no experience of overdose with Dafiro HCT.
Croatian: Nema iskustva s predoziranjem Dafiro HCT-om.
English: NSAIDS can attenuate the antihypertensive effect of both angiotensin II antagonists and hydrochlorothiazide when administered simultaneously.
Croatian: Pri istodobnoj primjeni, NSAIL-i mogu oslabiti antihipertenzivni učinak i antagonista angiotenzina II i hidroklorotiazida.
English: Based on available data from epidemiological studies, cumulative dose-dependent association between hydrochlorothiazide and NMSC has been observed.
Croatian: Na temelju dostupnih podataka iz epidemioloških ispitivanja, između hidroklorotiazida i NMSC-a primijećena je povezanost ovisna o kumulativnoj dozi.
English: However, amlodipine, valsartan and hydrochlorothiazide have been tested individually for genotoxicity and carcinogenicity with negative results.
Croatian: Međutim, ispitivanja genotoksičnosti i karcinogenosti su provedena pojedinačno za amlodipin, valsartan i hidroklorotiazid s negativnim rezultatima.
English: The maximum recommended dose of Dafiro HCT is 10 mg/320 mg/25 mg.
Croatian: Najviša preporučena doza Dafiro HCT-a je 10 mg/320 mg/25 mg.
English: • altered bowel habits
Croatian: • promijene navike pražnjenja crijeva
English: Muscular weakness
Croatian: Mišićna slabost
English: If photosensitivity reaction occurs during treatment with Dafiro HCT, it is recommended to stop the treatment.
Croatian: Ako se tijekom liječenja Dafiro HCT-om javi fotosenzitivna reakcija, preporučuje se prekinuti liječenje.
English: Medicinal products that could induce torsades de pointes
Croatian: Lijekovi koji bi mogli izazvati pojavu torsades de pointes
English: If any of the above applies to you, do not take Dafiro HCT and talk to your doctor.
Croatian: Ako se bilo što od navedenog odnosi na Vas, nemojte uzeti Dafiro HCT i obavijestite svog liječnika.
English: In patients with mild to moderate hepatic impairment without cholestasis, the maximum recommended dose is 80 mg valsartan, and therefore, Dafiro HCT is not suitable in this group of patients (see sections 4.2, 4.3 and 5.2).
Croatian: U bolesnika s blagim do umjerenim oštećenjem jetre, bez kolestaze, najviša preporučena doza valsartana je 80 mg, stoga Dafiro HCT nije prikladan u toj skupini bolesnika (vidjeti dijelove 4.2, 4.3 i 5.2).
English: • weakness, bruising and frequent infections (aplastic anaemia)
Croatian: • slabost, stvaranje modrica i učestale infekcije (aplastična anemija)
English: • low level of magnesium in the blood
Croatian: • niska razina magnezija u krvi
English: No formal interaction studies with other medicinal products have been performed with Dafiro HCT.
Croatian: Nisu provedena formalna ispitivanja interakcija Dafiro HCT-a s drugim lijekovima.
English: This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active substance amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of Dafiro HCT.
Croatian: Grejp i sok od grejpa u nekih bolesnika može dovesti do povećanja razina djelatne tvari amlodipina u krvi, što može uzrokovati neočekivano pojačani učinak Dafiro HCT-a na snižavanje krvnog tlaka.
English: if the level of potassium or sodium in your blood is too low despite treatment to increase the potassium or sodium levels in your blood.
Croatian: ako je razina kalija ili natrija u Vašoj krvi preniska unatoč liječenju za povećanje razina kalija ili natrija u Vašoj krvi.
English: Thiazide diuretics can precipitate new onset hyponatraemia and hypochloroaemic alkalosis or exacerbate pre-existing hyponatraemia.
Croatian: Tiazidski diuretici mogu uzrokovati novi nastup hiponatrijemije i hipokloremijske alkaloze ili pogoršati već postojeću hiponatrijemiju.
English: • weakness, bruising, fever and frequent infections
Croatian: • slabost, stvaranje modrica, vrućica i učestale infekcije
English: The site of action of thiazide diuretics is primarily in the renal distal convoluted tubule.
Croatian: Mjesto djelovanja tiazidnih diuretika primarno je distalni zavijeni tubul bubrega.
English: Concomitant use of Dafiro HCT with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m2) (see sections 4.5 and 5.1).
Croatian: Istodobna primjena Dafiro HCT s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem bubrega (GFR <60 ml/min/1,73 m2) (vidjeti dijelove 4.5 i 5.1).
English: Amlodipine is excreted in human milk.
Croatian: Amlodipin se izlučuje u mlijeko liječenih žena.
English: Caution is advised in patients with heart failure and coronary artery disease, particularly at the maximum dose of Dafiro HCT, 10 mg/320 mg/25 mg, since available data in these patient populations is limited.
Croatian: Savjetuje se oprez u bolesnika sa zatajivanjem srca i bolešću koronarnih arterija, osobito pri najvišoj dozi Dafiro HCT-a, 10 mg/320 mg/25 mg, jer su dostupni podaci u ovoj populaciji bolesnika ograničeni.
English: • liver disorder
Croatian: • poremećaj jetre
English: • weight decrease
Croatian: • smanjenje tjelesne težine
English: At week 8, the mean reductions in systolic/diastolic blood pressure were 39.7/24.7 mmHg with Dafiro HCT, 32.0/19.7 mmHg with valsartan/hydrochlorothiazide, 33.5/21.5 mmHg with amlodipine/valsartan, and 31.5/19.5 mmHg with amlodipine/hydrochlorothiazide.
Croatian: U 8. tjednu, srednja vrijednost sniženja sistoličkog/dijastoličkog krvnog tlaka bila je 39,7/24,7 mmHg s Dafiro HCT-om, 32,0/19,7 mmHg s valsartanom/hidroklorotiazidom, 33,5/21,5 mmHg s amlodipinom/valsartanom te 31,5/19,5 mmHg s amlodipinom/hidroklorotiazidom.
English: Iodine contrasting agents
Croatian: Jodna kontrastna sredstva
English: • severely decreased urine output (possible signs of renal disorder or renal failure)
Croatian: • jako smanjeno mokrenje (mogući znakovi poremećaja bubrega ili zatajivanja bubrega)
English: Antidiabetic agents (e.g. insulin and oral antidiabetic agents)
Croatian: Antidijabetički lijekovi (npr. inzulin i oralni antidijabetički lijekovi)
English: • severe skin disease that causes rash, red skin, blistering of the lips, eyes or mouth, skin peeling,
Croatian: • teška kožna bolest koja uzrokuje osip, crvenu kožu, stvaranje mjehurića na usnicama, očima ili ustima, ljuštenje kože, vrućica (multiformni eritem)
English: The reductions in systolic/diastolic blood pressure with Dafiro HCT were 7.6/5.0 mmHg greater than with valsartan/hydrochlorothiazide, 6.2/3.3 mmHg greater than with amlodipine/valsartan, and 8.2/5.3 mmHg greater than with amlodipine/hydrochlorothiazide.
Croatian: Sniženje sistoličkog/dijastoličkog krvnog tlaka postignuto Dafiro HCT-om bilo je 7,6/5,0 mmHg veće nego s valsartanom/hidroklorotiazidom, za 6,2/3,3 mmHg veće od onog s amlodipinom/valsartanom te za 8,2/5,3 mmHg veće od onog s amlodipinom/hidroklorotiazidom.
English: The hypokalaemic effect of hydrochlorothiazide may be increased by concomitant administration of kaliuretic diuretics, corticosteroids, laxatives, adrenocorticotropic hormone (ACTH), amphotericin, carbenoxolone, penicillin G and salicylic acid derivatives or antiarrhythmics.
Croatian: Istodobna primjena diuretika koji povećavaju izlučivanje kalija, kortikosteroida, laksativa, adrenokortikotropnog hormona (ACTH), amfotericina, karbenoksolona, penicilina G i derivata salicilne kiseline ili antiaritmici, mogu povećati hipokalijemijski učinak hidroklorotiazida.
English: CYP3A4 inducers (anticonvulsant agents [e.g. carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone], rifampicin, Hypericum perforatum [St. John's wort])
Croatian: CYP3A4 induktori (antikonvulzivni lijekovi [npr. karbamazepin, fenobarbital, fenitoin, fosfenitoin, primidon], rifampicin, Hypericum perforatum [gospina trava])
English: Amlodipine stops calcium from moving into the blood vessel wall, which stops the blood vessels from tightening.
Croatian: Amlodipin sprečava ulazak kalcija u stijenku krvne žile i tako sprečava sužavanje krvne žile.
English: Do not use any Dafiro HCT pack that is damaged or shows signs of tampering.
Croatian: Dafiro HCT se ne smije upotrijebiti ukoliko primjetite da je pakiranje oštećeno ili su vidljivi znakovi otvaranja.
English: Monitoring of potassium should be undertaken as appropriate.
Croatian: Po potrebi se može provesti praćenje kalija.
English: if you have a high level of calcium in your blood (with or without symptoms such as nausea, vomiting, constipation, stomach pain, frequent urination, thirst, muscle weakness and twitching).
Croatian: ako imate nisku razinu natrija u krvi (sa ili bez simptoma kao što su umor, smetenost, trzanje mišića, konvulzije). ako imate visoku razinu kalcija u krvi (sa ili bez simptoma kao što su mučnina, povraćanje, zatvor, bol u želucu, učestalo mokrenje, žeđ, slabost i trzanje mišića).
English: In patients with mild to moderate hepatic impairment without cholestasis, the maximum recommended dose is 80 mg valsartan and therefore Dafiro HCT is not suitable in this group of patients (see sections 4.3, 4.4 and 5.2).
Croatian: U bolesnika s blagim do umjerenim oštećenjem jetre, bez kolestaze, najviša preporučena doza valsartana je 80 mg te Dafiro HCT stoga nije pogodan za ovu skupinu bolesnika (vidjeti dijelove 4.3, 4.4 i 5.2).
English: • high level of uric acid in the blood
Croatian: • visoka razina mokraćne kiseline u krvi
English: Dafiro HCT should be used only after correction of any pre-existing sodium and/or volume depletion.
Croatian: Dafiro HCT smije se primjenjivati tek nakon korigiranja snižene razine natrija i/ili volumena tekućine.
English: Valsartan Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels
Croatian: Valsartan Diuretici koji štede kalij, nadomjesci kalija, zamjene soli koje sadrže kalij i ostale tvari koje mogu povećati razine kalija
English: Amlodipine dose recommendations have not been established in patients with mild to moderate hepatic impairment.
Croatian: Preporučena doza amlodipina nije utvrđena u bolesnika s blagim do umjerenim oštećenjem jetre.
English: Dafiro HCT is contraindicated in patients with severe renal impairment, anuria or undergoing dialysis (see section 4.3).
Croatian: Dafiro HCT je kontraindiciran u bolesnika s teškim oštećenjem bubrega, anurijom ili u bolesnika na dijalizi (vidjeti dio 4.3).
English: Medicinal products affecting serum sodium level
Croatian: Lijekovi koji utječu na razinu natrija u serumu
English: Amlodipine/Valsartan/Hydrochlorothiazide
Croatian: Amlodipin/Valsartan/Hidroklorotiazid
English: Due to the valsartan component, Dafiro HCT is contraindicated in patients with severe hepatic impairment (see section 4.3).
Croatian: Zbog komponente valsartana, Dafiro HCT je kontraindiciran u bolesnika s teškim oštećenjem jetre (vidjeti dio 4.3).
English: Serum levels of calcium should be periodically monitored during treatment with thiazides.
Croatian: Tijekom liječenja s tiazidima potrebno je periodički pratiti razine kalcija u serumu.