FrancophonIA/ELRC3.0 huggingface dataset:
English: Usually, these skin changes remain local and can be removed with surgery and treatment with Mekinist and dabrafenib can be continued without interruption.
Croatian: Obično te kožne promjene ostaju lokalne i mogu se ukloniti kirurškim zahvatom, a liječenje Mekinistom i dabrafenibom može se nastaviti bez prekida.
English: Although smaller female subjects are predicted to have higher exposure than heavier male subjects, these differences are unlikely to be clinically relevant and no dosage adjustment is warranted.
Croatian: Iako se predviđa da će izloženost biti veća u ispitanica ženskog spola i manje tjelesne težine nego u težih ispitanika muškog spola, nije vjerojatno da bi te razlike mogle biti klinički značajne i stoga nije potrebno prilagođavati dozu.
English: In the clinical trials only patients with cutaneous melanoma were studied.
Croatian: U kliničkim su ispitivanjima ispitivani samo bolesnici s kožnim melanomom.
English: Drug-drug interactions via these hydrolytic enzymes cannot be ruled out and could influence the exposure to trametinib.
Croatian: Interakcije između lijekova posredovane spomenutim hidrolitičkim enzimima ne mogu se isključiti te mogu utjecati na izloženost trametinibu.
English: Studies in juvenile animals have shown adverse effects of trametinib which were not observed in adult animals (see section 5.3).
Croatian: Ispitivanja na mladim životinjama pokazala su štetne učinke trametiniba koji nisu opaženi u odraslih životinja (vidjeti dio 5.3).
English: Grade 2-3 RPED that improves to Grade 0-1 within 3 weeks
Croatian: RPED 2. ili 3. stupnja koji se poboljša na 0. ili 1. stupanj unutar 3 tjedna
English: The mean absolute bioavailability of a single 2 mg tablet dose is 72% relative to an intravenous (IV) microdose.
Croatian: Srednja vrijednost apsolutne bioraspoloživosti jedne doze od 2 mg u obliku tablete iznosi 72% u odnosu na intravensku (i.v.) mikrodozu.
English: • If you are a woman who could become pregnant, you must use reliable birth control (contraception) while you are taking Mekinist and for at least 16 weeks after you stop taking it.
Croatian: • Ako ste žena koja bi mogla zatrudnjeti, morate koristiti pouzdanu kontracepciju tijekom liječenja lijekom Mekinist i još najmanje 16 tjedana po njegovu završetku.
English: The assay was specifically designed to differentiate between the V600E and V600K mutations.
Croatian: Taj je test posebno osmišljen da razlikuje mutacije V600E i V600K.
English: Of the patients with confirmed disease progression in the chemotherapy arm, a total of 51 (47%) crossed over to receive trametinib.
Croatian: Među bolesnicima s potvrđenom progresijom bolesti u skupini liječenoj kemoterapijom, ukupno je 51 (47%) bolesnik prešao u skupinu koja je primala trametinib.
English: • Birth control using hormones (such as pills, injections or patches) may not work as well if you are taking Mekinist or combination treatment (Mekinist as well as dabrafenib).
Croatian: • Hormonska kontracepcijska sredstva (poput pilula, injekcija ili flastera) možda neće biti jednako djelotvorna dok uzimate Mekinist ili kombiniranu terapiju (Mekinist i dabrafenib).
English: In a Phase III trial, 2.4% (5/211) of patients treated with trametinib monotherapy developed ILD or pneumonitis; all five patients required hospitalisation.
Croatian: U ispitivanju faze III se u 2,4% (5/211) bolesnika liječenih monoterapijom trametinibom razvio IBP ili pneumonitis; svih pet bolesnika moralo je biti hospitalizirano.
English: In the Phase III study with trametinib in patients with unresectable or metastatic melanoma (n=211), 49 patients (23%) were ≥65 years of age, and 9 patients (4%) were ≥75 years of age.
Croatian: U ispitivanju faze III u kojem je trametinib primjenjivan u bolesnika s neoperabilnim ili metastatskim melanomom (n=211), 49 bolesnika (23%) bilo je u dobi ≥ 65 godina, a 9 bolesnika (4%) u dobi ≥ 75 godina.
English: As it cannot be excluded that strong inhibition of hepatic P-gp may result in increased levels of trametinib, caution is advised when co-administering trametinib with medicinal products that are strong inhibitors of P-gp (e.g. verapamil, cyclosporine, ritonavir, quinidine, itraconazole).
Croatian: Kako se ne može isključiti da jaka inhibicija jetrenog P-gp-a može rezultirati povećanim razinama trametiniba, preporučuje se oprez kad se trametinib primjenjuje istodobno s lijekovima koji su jaki inhibitori P-gp-a (npr. verapamil, ciklosporin, ritonavir, kinidin, itrakonazol).
English: It is recommended that the dose of trametinib is taken at a similar time every day.
Croatian: Preporučuje se uzimati dozu trametiniba svakoga dana u približno isto vrijeme.
English: Withhold trametinib for up to 3 weeks.
Croatian: Odgoditi primjenu trametiniba do 3 tjedna.
English: In embryo-foetal developmental toxicity studies in rats and rabbits, trametinib induced maternal and developmental toxicity.
Croatian: U ispitivanjima embriofetalne razvojne toksičnosti na štakorima i kunićima trametinib je izazvao toksičnost za majku i razvojnu toksičnost.
English: The secondary endpoints were PFS in the ITT population and OS, ORR, and DoR in the primary efficacy population and ITT population.
Croatian: Mjere sekundarnog ishoda bile su PFS u ITT populaciji te OS, ORR i DoR a u primarnoj populaciji za ispitivanje djelotvornosti i ITT populaciji.
English: If your doctor decides that you will receive treatment with the combination of Mekinist and dabrafenib, read the dabrafenib leaflet carefully as well as this leaflet.
Croatian: Ako Vaš liječnik odluči da ćete primati terapiju s kombinacijom Mekinista i dabrafeniba, pažljivo pročitajte uputu o dabrafenibu kao i ovu uputu.
English: Male patients taking trametinib in combination with dabrafenib should be informed of the potential risk for impaired spermatogenesis, which may be irreversible.
Croatian: Muški bolesnici koji uzimaju trametinib u kombinaciji s dabrafenibom trebaju biti informirani o potencijalnom riziku od narušene spermatogeneze, koja bi mogla biti nepovratna.
English: Less than 0.1% of the excreted dose was recovered as parent in urine.
Croatian: Manje od 0,1% izlučene doze pronađeno je u obliku ishodišne tvari u mokraći.
English: Taking Mekinist or the combination of Mekinist and dabrafenib can cause serious bleeding including in your brain, the digestive system (such as stomach, rectum or intestine), lungs, and other organs, and can lead to death.
Croatian: Uzimanje Mekinista ili kombinacije Mekinista i dabrafeniba može uzrokovati ozbiljno krvarenje uključujući i u Vašem mozgu, probavnom sustavu (kao što je želudac, rektum ili crijeva), plućima i drugim organima te može dovesti do smrti.
English: - The active substance is trametinib.
Croatian: - Djelatna tvar je trametinib.
English: The primary endpoint of the study was OS with a key secondary endpoint of PFS.
Croatian: Mjera primarnog ishoda u ispitivanju bio je OS uz ključnu mjeru sekundarnog ishoda PFS.
English: The dabrafenib doses should be about 12 hours apart.
Croatian: Između doza dabrafeniba mora biti 12 sati razmaka.
English: Trametinib has a volume of distribution of approximately 1200 L determined following administration of a 5 g intravenous microdose.
Croatian: Volumen distribucije trametiniba iznosi približno 1200 l, što je izmjereno nakon primjene intravenske mikrodoze od 5 µg.
English: Cases of cuSCC can be managed with excision and do not require treatment modification.
Croatian: Slučajevi cuSCC-a mogu se zbrinuti ekscizijom i ne zahtijevaju prilagodbu terapije.
English: To prevent pregnancy, female patients using hormonal contraception are advised to use an additional or alternative method during treatment and for 16 weeks following discontinuation of trametinib.
Croatian: Kako bi se spriječila trudnoća, bolesnicama koje koriste hormonske kontraceptive savjetuje se primjena dodatne ili alternativne metode tijekom liječenja trametinibom i još 16 tjedana po njegovu završetku.
English: Subsequently, all patient samples were re-tested using the CE-marked bioMerieux (bMx) THxID BRAF validated assay.
Croatian: Nakon toga su svi uzorci prikupljeni u bolesnika ponovno testirani primjenom validiranog testa tvrtke bioMerieux (bMx) THxID BRAF, koji nosi oznaku CE.
English: • have heart problems such as heart failure (which can cause shortness of breath, difficulty in breathing when lying down, swelling of the feet or legs) or problems with the way your heart beats.
Croatian: • imate tegobe sa srcem kao što su zatajenje srca (koji mogu uzrokovati nedostatak zraka, otežano disanje dok ležite, oticanje stopala ili nogu) ili problemi s otkucajima srca.
English: Kaplan-Meier curves of investigator-assessed OS (post-hoc analysis 20 May 2013) is presented in Figure 3.
Croatian: Kaplan-Meierove krivulje OS-a prema ocjeni ispitivača (post-hoc analiza, 20. svibnja 2013.) prikazane su na slici 3.
English: Hazard ratio is obtained from the stratified Pike model.
Croatian: Omjer hazarda je dobiven iz stratificiranog Pike modela.
English: Use with dabrafenib may render hormonal contraceptives less effective and therefore an alternative method of contraception, such as a barrier method, should be used when trametinib is used in combination with dabrafenib.
Croatian: Primjena uz dabrafenib može smanjiti učinkovitost hormonskih kontraceptiva pa je stoga potrebno koristiti zamjensku metodu kontracepcije, poput metode barijere, kada se trametinib primjenjuje u kombinaciji s dabrafenibom.
English: Figure 3 Kaplan-Meier curves of overall survival (OS -ad hoc analysis 20 May 2013)
Croatian: Slika 3 Kaplan-Meierove krivulje ukupnog preživljenja (ad hoc analiza, 20. svibnja 2013.)
English: Mekinist should be taken with either the morning dose of dabrafenib or the evening dose of dabrafenib.
Croatian: Mekinist treba uzimati ili s jutarnjom dozom dabrafeniba ili s večernjom dozom dabrafeniba.
English: Most patients (87%) in the ITT population had BRAF V600E mutation and 12% of patients had BRAF V600K.
Croatian: Većina bolesnika (87%) u ITT populaciji imala je BRAF mutaciju V600E i 12% bolesnika imalo je BRAF mutaciju V600K.
English: Some people taking Mekinist in combination with dabrafenib may also notice that new melanomas have appeared.
Croatian: Neke osobe koje uzimaju Mekinist u kombinaciji s dabrafenibom mogu primijetiti i pojavu novih melanoma.
English: 9.2d (7.4, NR)
Croatian: 9,2d (7,4; ND)
English: Mekinist in combination with dabrafenib is also used to prevent melanoma from coming back after it has been removed by surgery.
Croatian: Mekinist u kombinaciji s dabrafenibom koristi se i za sprječavanje povratka melanoma nakon što je odstranjen operacijom.
English: In melanoma and other cancers, this pathway is often activated by mutated forms of BRAF which activates MEK.
Croatian: Kod melanoma i drugih vrsta raka, spomenuti signalni put često aktiviraju mutirani oblici BRAF gena, koji aktivira MEK.
English: Frequency (all grades)
Croatian: Učestalost (svi stupnjevi) Nuspojave
English: 7.5d a - Progression-free survival (investigator assessed) b - Overall Response Rate = Complete Response + Partial Response c - Duration of response d - At the time of the reporting the majority (59% of dabrafenib+trametinib and 42% of vemurafenib) of investigator-assessed responses were still ongoing
Croatian: d a - Preživljenje bez progresije (procjena ispitivača) b - Ukupna stopa odgovora = kompletan odgovor + djelomični odgovor c - Trajanje odgovora d - U vrijeme izvješćivanja većina (59% za dabrafenib+trametinib i 42% za vemurafenib) odgovora koje je procijenio ispitivač bila je još u tijeku ND = Nije dostignuto
English: The safety of trametinib in subjects with predisposing factors for RVO, including uncontrolled glaucoma or ocular hypertension, uncontrolled hypertension, uncontrolled diabetes mellitus, or a history of hyperviscosity or hypercoagulability syndromes, has not been established.
Croatian: Nije ustanovljena sigurnost trametiniba u ispitanika s predisponirajućim faktorima za RVO, uključujući nekontrolirani glaukom ili očnu hipertenziju, nekontroliranu hipertenziju, nekontroliranu šećernu bolest ili sindrom hiperviskoznosti ili hiperkoagulabilnosti u anamnezi.
English: The assay was designed to detect the BRAF V600E and V600K mutations with high sensitivity (down to 5% V600E and V600K sequence in a background of wild-type sequence using DNA extracted from FFPE tissue).
Croatian: Test je osmišljen tako da s visokom osjetljivošću otkrije BRAF mutacije V600E i V600K (do 5% sekvence V600E i V600K na pozadini sekvence divljeg tipa s DNK dobivene iz FFPE tkiva).
English: No dose modifications are required for uveitis as long as effective local therapies can control ocular inflammation.
Croatian: Nisu potrebne prilagodbe doze zbog uveitisa dokle god se upala oka može kontrolirati učinkovitim lokalnim terapijama.
English: Please read the dabrafenib Package Leaflet for details of the side effects you may get when taking this medicine.
Croatian: Pročitajte uputu o lijeku za dabrafenib za pojedinosti o nuspojavama koje biste mogli dobiti kada uzimate ovaj lijek.
English: This is to look for any new skin cancers.
Croatian: Razlog tome je da se vidi imate li bilo koje nove rakove kože.
English: Your doctor may arrange to check your lung function before you start taking your medicine.
Croatian: Liječnik će možda dati provjeriti Vašu plućnu funkciju prije nego što počnete uzimati lijek.
English: You may also get additional side effects due to taking dabrafenib at the same time as Mekinist in the list below.
Croatian: Mogli biste dobiti i dodatne nuspojave zbog uzimanja dabrafeniba istodobno s Mekinistom, a navedene su na popisu u nastavku.
English: Patients with left ventricular dysfunction, New York Heart Association Class II, III, or IV heart failure, acute coronary syndrome within the past 6 months, clinically significant uncontrolled arrhythmias, and uncontrolled hypertension were excluded from clinical trials; safety of use in this population is therefore unknown.
Croatian: New York Heart Association, NYHA) II., III. ili IV. stupnja, akutnim koronarnim sindromom unutar prethodnih 6 mjeseci, klinički značajnim nekontroliranim aritmijama i nekontroliranom hipertenzijom; stoga nije poznata sigurnost primjene u toj populaciji.
English: In a study in dogs in which trametinib and dabrafenib were given in combination for 4 weeks, signs of gastro-intestinal toxicity and decreased lymphoid cellularity of the thymus were observed at lower exposures than in dogs given trametinib alone.
Croatian: U ispitivanju na psima u kojem su se trametinib i dabrafenib davali u kombinaciji tijekom 4 tjedna, bili su uočeni znakovi gastrointestinalne toksičnosti i smanjena celularnost limfnog tkiva timusa pri nižim izloženostima nego u pasa kojima se davao samo trametinib.
English: Based on cross-study comparisons, overall survival and progression-free survival data appear to show similar effectiveness between trametinib and BRAF inhibitors; however, overall response rates were lower in patients treated with trametinib than those reported in patients treated with BRAF inhibitors.
Croatian: Na temelju usporedbe podataka iz različitih ispitivanja, čini se da je učinkovitost trametiniba i BRAF inhibitora slična s obzirom na ukupno preživljenje i preživljenje bez progresije bolesti; međutim, stope ukupnog odgovora u bolesnika liječenih trametinibom bile su niže nego one prijavljene u bolesnika koji su liječeni BRAF inhibitorima.
English: Uncommon ≥1/1,000 to <1/100 Rare
Croatian: ≥ 1/100 i < 1/10 manje često ≥ 1/1000 i < 1/100 rijetko
English: Treatment with trametinib should only be initiated and supervised by a physician experienced in the administration of anti-cancer medicinal products.
Croatian: Liječenje trametinibom mora započeti i nadzirati samo liječnik s iskustvom u primjeni antitumorskih lijekova.
English: No data are available in patients with moderate or severe hepatic impairment.
Croatian: Nema dostupnih podataka o bolesnicima s umjerenim ili teškim oštećenjem jetrene funkcije.
English: The management of adverse reactions may require dose reduction, treatment interruption or treatment discontinuation (see Tables 1 and 2).
Croatian: Zbrinjavanje nuspojava može zahtijevati smanjivanje doze, privremeni prekid liječenja ili trajnu obustavu liječenja (vidjeti tablice 1 i 2).
English: earlier in section 4)
Croatian: (vidom)“ ranije u dijelu 4)
English: High blood pressure
Croatian: Povišen krvni tlak
English: Call your doctor or nurse right away if you develop high blood pressure, your blood pressure worsens, or you have severe headache, light-headedness, or dizziness.
Croatian: Odmah se javite svom liječniku ili medicinskoj sestri ako dođe do povišenja krvnog tlaka, ako se postojeći visok krvni tlak pogorša ili ako imate tešku glavobolju, ošamućenost ili omaglicu.
English: The response was durable with median DoR in the previously-treated population reaching 9.8 months (95% CI, 6.9, 16.0) by investigator assessment.
Croatian: Odgovor je bio dugotrajan uz medijan DoR-a u prethodno liječenoj populaciji od 9,8 mjeseci (95% CI, 6,9; 16,0) prema procjeni ispitivača.
English: In rats, hypertrophy of the physis and increased bone turnover were observed, but the physeal hypertrophy is not expected to be clinically relevant for adult humans.
Croatian: U štakora su primijećene hipertrofija epifizne ploče i povećanje koštane pregradnje, ali se ne očekuje da bi hipertrofija epifizne ploče mogla biti klinički značajna u odraslih ljudi.
English: • Swelling around the eyes
Croatian: • oticanje oko očiju
English: Mekinist is not recommended while breast-feeding It is not known whether the ingredients of Mekinist can pass into breast milk.
Croatian: Ne preporučuje se primjena lijeka Mekinist tijekom dojenja Nije poznato mogu li se sastojci lijeka Mekinist izlučiti u majčino mlijeko.
English: Based on in vitro studies, trametinib is not an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2D6 and CYP3A4.
Croatian: In vitro ispitivanja pokazala su da trametinib nije inhibitor CYP1A2, CYP2A6, CYP2B6, CYP2D6 ni CYP3A4.
English: Subjects were stratified by lactate dehydrogenase (LDH) level (> the upper limit of normal (ULN) versus ULN) and BRAF mutation (V600E versus V600K).
Croatian: Ispitanici su bili stratificirani prema razini laktat dehidrogenaze (LDH) (> gornje granice normale (GGN) naspram  GGN) i BRAF mutaciji (V600E naspram V600K).
English: • have eye problems including blockage of the vein draining the eye (retinal vein occlusion) or swelling in the eye which may be caused by fluid blockage (chorioretinopathy).
Croatian: • imate tegobe s očima uključujući blokadu vene koja istječe iz oka (okluzija mrežnične vene) ili oticanje u oku koje može biti uzrokovano blokadom tekućine (korioretinopatija).
English: Mekinist can have side effects that may affect your ability to drive or use machines.
Croatian: Mekinist može izazvati nuspojave koje mogu utjecati na Vašu sposobnost upravljanja vozilima ili rada na strojevima.
English: Additionally, in juvenile rats given trametinib, decreased ovarian weights, slight delays in hallmarks of female sexual maturation (vaginal opening and increased incidence of prominent terminal end buds within the mammary gland) and slight hypertrophy of the surface epithelium of the uterus were observed.
Croatian: Dodatno, u mladih štakora kojima je davan trametinib opaženo je smanjenje mase jajnika, neznatna kašnjenja u pojavi obilježja ženskog spolnog sazrijevanja (vaginalni otvor i povećana incidencija istaknutih terminalnih završetaka pupoljaka unutar mliječne žlijezde) i neznatna hipertrofija površine epitela maternice.
English: However, based on the low dose and low clinical systemic exposure relative to the in vitro potency of inhibition or induction values, trametinib is not considered to be an in vivo inhibitor or inducer of these enzymes or transporters, although transient inhibition of BCRP substrates in the gut may occur (see section 4.5).
Croatian: Međutim, s obzirom na nisku dozu i nisku kliničku sistemsku izloženost u odnosu na potentnost inhibicijske ili indukcijske vrijednosti in vitro, smatra se da trametinib nije inhibitor niti induktor spomenutih enzima ili prijenosnika in vivo, iako je moguća prolazna inhibicija supstrata za BCRP u crijevu (vidjeti dio 4.5).
English: 7 tablets 30 tablets
Croatian: 30 tableta
English: Mekinist can cause inflammation of the lung (pneumonitis or interstitial lung disease).
Croatian: Mekinist može izazvati upalu pluća (pneumonitis ili intersticijsku bolest pluća).
English: Effect of trametinib on other medicinal products
Croatian: Učinak trametiniba na druge lijekove
English: There are no data with trametinib in patients with severe renal impairment; therefore, the potential need for starting dose adjustment cannot be determined.
Croatian: Nema podataka o primjeni trametiniba u bolesnika s teškim oštećenjem bubrežne funkcije; stoga se ne može utvrditi moguća potreba za prilagodbom početne doze.
English: Trametinib accumulates with repeat daily dosing with a mean accumulation ratio of 6.0 at 2 mg once daily dose.
Croatian: Trametinib se kumulira s ponovljenim dnevnim dozama sa srednjom vrijednošću omjera kumulacije od 6,0 pri dozi od 2 mg jedanput na dan.
English: Of the hepatic adverse reactions, increased ALT and AST were the most common events and the majority were either Grade 1 or 2.
Croatian: Najčešće nuspojave povezane s jetrom bile su povišene razine ALT-a i AST-a, koje su većinom bile 1. ili 2. stupnja.
English: More frequent dose adjustments (see Tables 1 and 2 above) may be required in patients >65 years of age (see section 4.8).
Croatian: U bolesnika starijih od 65 godina možda će biti potrebne češće prilagodbe doze (vidjeti tablice 1 i 2 gore) (vidjeti dio 4.8).
English: Female patients of reproductive potential must be advised to use effective methods of contraception during treatment with trametinib and for 16 weeks after stopping treatment.
Croatian: Ženama reproduktivne dobi se mora savjetovati da koriste učinkovite metode kontracepcije tijekom liječenja trametinibom i još 16 tjedana po njegovu završetku.
English: Patients should be made aware of potential for fatigue, dizziness or eye problems that might affect these activities.
Croatian: Bolesnike treba upozoriti na mogući umor, omaglicu ili očne tegobe, koji bi mogli utjecati na izvođenje spomenutih aktivnosti.
English: Among the total of 93 patients who were enrolled in the combination therapy cohorts B and C, most patients were Caucasian (>90%), and similar female versus male (54% versus 46%), with a median age of 64 years in second-line or higher patients and 68 years in the first-line patients.
Croatian: Od ukupno 93 bolesnika koliko ih je bilo uključeno u kohorte B i C koje su primale kombiniranu terapiju, većina su bili bijelci (>90%), sa sličnim omjerom žena u odnosu na muškarce (54% naspram 46%), uz medijan dobi od 64 godine u bolesnika na drugoj ili višoj liniji terapije te 68 godina u bolesnika na prvoj liniji.
English: Non-clinical and clinical trials with retrospective bi-directional Sanger sequencing analyses have shown that the test also detects the less common BRAF V600D mutation and V600E/K601E mutation with lower sensitivity.
Croatian: Neklinička i klinička ispitivanja s retrospektivnim dvosmjernim Sangerovim sekvencijskim analizama pokazala su da ovaj test s manjom osjetljivošću otkriva i manje čestu BRAF mutaciju V600D te mutaciju V600E/K601E.
English: In animals, no fertility studies have been performed, but adverse effects were seen on female reproductive organs (see section 5.3).
Croatian: Nisu provedena ispitivanja plodnosti na životinjama, no primijećeni su štetni učinci na reproduktivne organe ženki (vidjeti dio 5.3).
English: In studies MEK115306 and MEK116513 <1% (2/209) and 1 % (4/350), respectively, of patients treated with trametinib in combination with dabrafenib developed pneumonitis or ILD (see section 4.8).
Croatian: U ispitivanjima MEK115306 i MEK116513 u < 1% (2/209) odnosno 1% (4/350) bolesnika liječenih trametinibom u kombinaciji s dabrafenibom razvio se pneumonitis ili IBP (vidjeti dio 4.8).
English: 30 days at no more than 30ºC.
Croatian: Otvorena bočica 30 dana na temperaturi ne višoj od 30°C.
English: If you stop taking Mekinist Take Mekinist for as long as your doctor recommends.
Croatian: Uzimajte Mekinist onoliko dugo koliko Vam liječnik preporuči.