FrancophonIA/ELRC3.0 huggingface dataset:
English: As a general rule, when deciding to use antiretroviral agents for the treatment of HIV infection in pregnant women, and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account in order to characterise the safety for the foetus.
Danish: For at definere sikkerheden for fostret skal såvel dyredata som kliniske erfaringer hos gravide kvinder som hovedregel tages i betragtning, når det besluttes at anvende antiretrovirale lægemidler til behandling af hiv-infektion hos gravide og dermed reducere risikoen for vertikal transmission af hiv til den nyfødte.
English: General disorders and administration site conditions common fatigue uncommon sluggishness
Danish: Almene symptomer og reaktioner på administrationsstedet almindelig træthed ikke almindelig sløvhed
English: Co-administration with elbasvir/grazoprevir (see section 4.5).
Danish: Samtidig administration med elbasvir/grazoprevir (se pkt.
English: ≥ 25 to < 30 kg
Danish: ≥ 25 til < 30 kg
English: TMC125-C213 6 to < 12 years ETR N = 41
Danish: TMC125-C213 6 til < 12 år ETR N = 41
English: Store in the original bottle and keep the bottle tightly closed in order to protect from moisture.
Danish: Opbevar i den originale beholder og hold beholderen tæt tillukket for at beskytte mod fugt.
English: Unchanged etravirine accounted for 81.2% to 86.4% of the administered dose in faeces.
Danish: 81,2-86,4 % af den indgivne dosis fandtes uforandret i fæces.
English: ≥ 20 to < 25 kg
Danish: ≥ 20 til < 25 kg
English: For further information on interactions with medicinal products see section 4.5.
Danish: Yderligere oplysninger om interaktioner med lægemidler findes i pkt.
English: Placebo arms N = 569
Danish: Placebogrupper N = 569
English: Clarithromycin exposure was decreased by etravirine; however, concentrations of the active metabolite, 14-OH-clarithromycin, were increased.
Danish: Clarithromycineksponeringen blev reduceret af etravirin, men koncentrationen af den aktive metabolit,
English: Renal impairment No dose adjustment is required in patients with renal impairment (see section 5.2).
Danish: Nedsat nyrefunktion Der kræves ingen dosisjustering til patienter med nedsat nyrefunktion (se pkt.
English: EXP Do not use after 6 weeks of first opening the bottle.
Danish: EXP Må ikke anvendes senere end 6 uger efter første åbning af beholderen.
English: EXP Do not use after 8 weeks of first opening the bottle.
Danish: EXP Må ikke anvendes senere end 8 uger efter første åbning af beholderen.
English: 20 mg once daily paroxetine
Danish: 20 mg en gang dagligt paroxetin
English: Rash was mostly self-limiting, and generally resolved within 1-2 weeks on continued therapy (see section 4.4).
Danish: Udslæt var for det meste selvbegrænsende og forsvandt generelt inden for 1 til 2 uger med fortsat behandling (se pkt.
English: OESTROGEN-BASED CONTRACEPTIVES Ethinylestradiol
Danish: ØSTROGENBASEREDE ANTIKONCEPTIVA Ethinyløstradiol
English: Medicinal products that are affected by the use of etravirine
Danish: Lægemidler, som påvirkes af etravirin
English: - Tell your doctor if you have or have had problems with your liver, including hepatitis B and/or C. Your doctor may evaluate how severe your liver disease is before deciding if you can take INTELENCE.
Danish: - Fortæl det til lægen, hvis du har eller har haft leverproblemer, herunder hepatitis B og/eller C (leverbetændelse).
English: If the patient misses a dose of INTELENCE within 6 hours of the time it is usually taken, the patient should take it following a meal as soon as possible and then take the next dose at the regularly scheduled time.
Danish: Hvis en patient glemmer at tage INTELENCE og kommer i tanke om dette inden for 6 timer efter det tidspunkt, hvor patienten skulle have taget lægemidlet, skal patienten tage den pågældende dosis efter et måltid så hurtigt som muligt og dernæst tage den følgende dosis på det sædvanlige tidspunkt.
English: Disopyramide Flecainide Lidocaine (systemic) Mexiletine Propafenone Quinidine
Danish: Lidocain (systemisk) Mexiletin
English: Concomitant use of etravirine with efavirenz or nevirapine may cause a significant decrease in the plasma concentration of etravirine and loss of therapeutic effect of etravirine.
Danish: Samtidig indgift af etravirin og efavirenz eller nevirapin kan forårsage signifikant reduktion i plasmakoncentrationen af etravirin og tab af terapeutisk virkning af etravirin.
English: Concomitant use of etravirine with indinavir may cause a significant decrease in the plasma concentration of indinavir and loss of therapeutic effect of indinavir.
Danish: Samtidig indgift af etravirin og indinavir kan forårsage signifikant reduktion i plasmakoncentrationen af indinavir og tab af den terapeutiske virkning af indinavir.
English: Baseline genotype or phenotype and virologic outcome analyses In DUET-1 and DUET-2, the presence at baseline of 3 or more of the following mutations: V90I, A98G, L100I, K101E, K101P, V106I, V179D, V179F, Y181C, Y181I, Y181V, G190A and G190S, (etravirine RAMs) was associated with a decreased virologic response to etravirine (see table 5).
Danish: Analyse af genotype eller fænotype og virologisk resultat ved baseline I DUET-1 og DUET-2 var forekomsten ved baseline af tre eller flere af følgende mutationer: V90I, A98G, L100I, K101E, K101P, V106I, V179D, V179F, Y181C, Y181I, Y181V, G190A og G190S (etravirin-resistensassocierede mutationer) forbundet med nedsat virologisk respons på etravirin (se tabel 5).
English: 40 mg once daily etravirine
Danish: 40 mg en gang dagligt etravirin
English: If you vomit more than 4 hours after taking INTELENCE, then you do not need to take another dose until your regularly scheduled dose.
Danish: Hvis du kaster op mere end 4 timer efter, at du har taget INTELENCE, behøver du ikke at tage en ny dosis, før det er tid til at tage den næste planlagte dosis.
English: Eye disorders common blurred vision
Danish: Øjne almindelig sløret syn
English: Furthermore, the presence of this mutation alone did not affect the response in the etravirine arm. Additional data is required to conclude on the influence of K103N when associated with other NNRTIs mutations.
Danish: Der kræves yderligere data for at vurdere indflydelsen fra K103N i forbindelse med mutationer ved andre NNRTI'er.
English: Recommendations concerning co-administration
Danish: Anbefalinger vedrørende samtidig indgift
English: Treatment-experienced paediatric patients (6 years to less than 18 years of age) PIANO is a single-arm, Phase II trial evaluating the pharmacokinetics, safety, tolerability, and efficacy of etravirine in 101 antiretroviral treatment-experienced HIV-1 infected paediatric patients 6 years to less than 18 years of age and weighing at least 16 kg.
Danish: Behandlingserfarne pædiatriske patienter (i alderen 6 år til yngre end 18 år) PIANO er et fase II-forsøg med en enkelt gruppe til evaluering af farmakokinetik, sikkerhed, tolerabilitet og virkning af etravirin hos 101 antiretroviralt behandlingserfarne pædiatriske patienter med hiv-1-infektion i alderen 6 år til yngre end 18 år og med en legemsvægt på mindst 16 kg. I studiet indgik patienter, der var i stabil antiretroviral behandling, men med virologisk svigt, og som havde en bekræftet viral load i plasma på ≥ 500 hiv-1 RNA kopier/ml.
English: - The other ingredients are hypromellose, silicified microcrystalline cellulose, microcrystalline cellulose, colloidal anhydrous silica, croscarmellose sodium and magnesium stearate.
Danish: - Øvrige indholdsstoffer: hypromellose, silificeret mikrokrystallinsk cellulose, mikrokrystallinsk cellulose, kolloid vandfri silica, croscarmellosenatrium og magnesiumstearat.
English: TMC125-C213 12 to < 18 years ETR N = 60
Danish: TMC125-C213 12 til < 18 år ETR N = 60
English: It is not recommended to co-administer tipranavir/ritonavir and INTELENCE (see section 4.4).
Danish: Det frarådes at indgive tipranavir/ritonavir samtidig med INTELENCE (se pkt.
English: Cmax ↔ 0.91 (0.58-1.42) etravirine
Danish: Cmax ↔ 0,91 (0,58-1,42) etravirin
English: 150 mg twice daily etravirine
Danish: 150 mg to gange dagligt etravirin
English: Etravirine 200 mg twice daily postpartum N = 10
Danish: 200 mg etravirin to gange dagligt post partum N = 10
English: Rash was reported more frequently in female subjects than in male subjects (rash ≥ grade 2 was reported in 13/64 [20.3%] females versus 2/37 [5.4%] males; discontinuations due to rash were reported in 4/64 [6.3%] females versus 0/37 [0%] males) (see section 4.4).
Danish: Der rapporteredes hyppigere udslæt hos kvindelige forsøgspersoner end hos mandlige (udslæt ≥ grad 2 forekom hos 13/64 [20,3 %] kvinder versus 2/37 [5,4 %] mænd.
English: Lovastatin, rosuvastatin and simvastatin are CYP3A4 substrates and co-administration with etravirine may result in lower plasma concentrations of the HMG Co-A reductase inhibitor.
Danish: Lovastatin, rosuvastatin og simvastatin er CYP3A4-substrater, og samtidig indgift med etravirin kan reducere plasmakoncentrationen af HMG-CoA-reduktasehæmmeren.
English: INTELENCE can be used with these NRTIs without dose adjustment.
Danish: INTELENCE kan anvendes sammen med disse NRTImidler uden dosisjustering.
English: P-value < 0.0001 for mean decrease in HIV-1 RNA; P-value = 0.0006 for mean change in CD4 cell count.
Danish: P-værdi = 0,0006 for gennemsnitlig ændring i CD4-celletal.
English: Etravirine (200 mg twice daily), evaluated in combination with other antiretroviral medicinal products in a study of 15 pregnant women during the second and third trimesters of pregnancy and postpartum, demonstrated that exposure to total etravirine was generally higher during pregnancy compared with postpartum, and less so for unbound etravirine exposure (see section 5.2).
Danish: Et studie, der evaluerede etravirin (200 mg to gange dagligt) i kombination med andre antiretrovirale lægemidler hos 15 gravide kvinder i andet og tredje trimester af graviditeten samt post partum, viste, at eksponering for total-etravirin generelt var højere under graviditet i forhold til post partum.
English: Etravirine is expected to increase plasma concentrations of diazepam.
Danish: Etravirin forventes at øge plasmakoncentrationen af diazepam.
English: In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Danish: Hos nogle patienter med fremskreden hiv-infektion, som tidligere har haft opportunistiske infektioner (dvs. infektioner, som raske mennesker er modstandsdygtige over for, og som kun angriber mennesker med nedsat immunforsvar), kan tegn og symptomer på betændelse fra tidligere infektioner vise sig straks efter påbegyndelse af hiv-behandling.
English: Tipranavir/ritonavir 500/200 mg twice daily tipranavir
Danish: Tipranavir/ritonavir 500/200 mg to gange dagligt tipranavir
English: A decreased virologic response to etravirine was observed in patients with viral strains harbouring 3 or more among the following mutations V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V, and G190A/S (see section 5.1).
Danish: Nedsat virologisk respons over for etravirin blev observeret hos patienter med virusstammer med tre eller flere af følgende mutationer: V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V og G190A/S (se pkt.
English: All ranges
Danish: Alle områder
English: Cmax ↓ 0.55 (0.40-0.75) N-desmethyl-sildenafil AUC ↓ 0.59 (0.52-0.68) Cmin ND
Danish: Cmax ↓ 0,55 (0,40-0,75) N-desmetylsildenafil AUC ↓ 0,59 (0,52-0,68) Cmin ND
English: No dose adjustment is suggested in patients with mild or moderate hepatic impairment (Child-Pugh Class A or B); INTELENCE should be used with caution in patients with moderate hepatic impairment.
Danish: Der anbefales ingen dosisjustering til patienter med let eller moderat nedsat leverfunktion (Child-Pugh-klasse A eller B).
English: The combination of INTELENCE and ribavirin can be used without dose adjustments.
Danish: Kombinationen af INTELENCE og ribavirin kan anvendes uden dosisjusteringer.
English: Overall de novo ENF
Danish: I alt de novo ENF
English: Therefore, INTELENCE is not recommended in patients with severe hepatic impairment (see sections 4.4 and 5.2).
Danish: INTELENCE anbefales derfor ikke til patienter med svært nedsat leverfunktion (se pkt.
English: Dexamethasone is expected to decrease plasma concentrations of etravirine
Danish: Dexamethason forventes at reducere plasmakoncentrationen af etravirin.
English: INTELENCE and darunavir/ritonavir can be used without dose adjustments (see also section 5.1).
Danish: INTELENCE og darunavir/ritonavir kan anvendes uden dosisjustering (se også pkt.
English: Most often, rash was mild to moderate, of macular/papular type, and occurred in the second week of therapy.
Danish: I de fleste tilfælde var udslættet let til moderat, makulopapulært og optrådte i den anden uge af behandlingen.
English: - Tell your doctor if you develop a rash.
Danish: - Fortæl det til lægen, hvis du får udslæt.
English: TMC125-C213 6 to < 18 years ETR N = 101
Danish: TMC125-C213 6 til < 18 år ETR N = 101
English: Rifampicin and rifapentine are expected to decrease plasma concentrations of etravirine.
Danish: Rifampicin og rifapentin forventes at reducere plasmakoncentration af etravirin.
English: During the 2
Danish: 2 år
English: Dolutegravir + Lopinavir/ritonavir 50 mg once daily + 400/100 mg twice daily dolutegravir AUC ↓ 0.29 (0.26-0.34) Cmin ↓ 0.12 (0.09-0.16) Cmax ↓ 0.48 (0.43-0.54) etravirine
Danish: Dolutegravir + Lopinavir/ritonavir 50 mg en gang dagligt + 400/100 mg to gange dagligt dolutegravir AUC ↓ 0,29 (0,26-0,34) Cmin ↓ 0,12 (0,09-0,16) Cmax ↓ 0,48 (0,43-0,54) etravirin
English: INTELENCE and these antifungals can be used without dose adjustments.
Danish: INTELENCE og disse antimykotika kan anvendes uden dosisjustering.
English: Excipient with known effect Each tablet contains less than 1 mmol sodium (23 mg), and is essentially sodium-free.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver tablet indeholder mindre end 1 mmol (23 mg) natrium og er i det væsentlige natriumfri.
English: Rash has been reported with etravirine.
Danish: Der er rapporteret udslæt ved brug af etravirin.
English: Darunavir/ritonavir 600/100 mg twice daily darunavir
Danish: Darunavir/ritonavir 600/100 mg to gange dagligt darunavir
English: INTELENCE can be co-administered with proton pump inhibitors without dose adjustments.
Danish: INTELENCE kan anvendes sammen med protonpumpehæmmere uden dosisjustering.
English: Hypromellose Microcrystalline cellulose Colloidal anhydrous silica Croscarmellose sodium Magnesium stearate Lactose monohydrate
Danish: Hypromellose Mikrokrystallinsk cellulose Kolloid vandfri silica Croscarmellosenatrium Magnesiumstearat Lactosemonohydrat
English: Clarithromycin 500 mg twice daily clarithromycin AUC ↓ 0.61 (0.53-0.69) Cmin ↓ 0.47 (0.38-0.57) Cmax ↓ 0.66 (0.57-0.77) 14-OH-clarithromycin AUC ↑ 1.21 (1.05-1.39) Cmin ↔ 1.05 (0.90-1.22) Cmax ↑ 1.33 (1.13-1.56) etravirine
Danish: Clarithromycin 500 mg to gange dagligt clarithromycin AUC ↓ 0,61 (0,53-0,69) Cmin ↓ 0,47 (0,38-0,57) Cmax ↓ 0,66 (0,57-0,77) 14-OH-clarithromycin AUC ↑ 1,21 (1,05-1,39) Cmin ↔ 1,05 (0,90-1,22) Cmax ↑ 1,33 (1,13-1,56) etravirin
English: If a patient vomits more than 4 hours after taking the medicine, the patient does not need to take another dose until the next regularly scheduled time.
Danish: Hvis patienten kaster op mere end 4 timer efter at have indtaget lægemidlet, skal vedkommende ikke tage en ny dosis, før det er tid til at tage den næste planlagte dosis.
English: Rash was mostly self-limiting and generally resolved within 1 week on continued therapy.
Danish: Udslættet var for det meste selvbegrænsende og forsvandt generelt i løbet af 1 uge, hvis behandlingen fortsattes.
English: Co-administration of etravirine and medicinal products that inhibit CYP3A4, CYP2C9 or CYP2C19 may decrease the clearance of etravirine and may result in increased plasma concentrations of etravirine.
Danish: Samtidig indgift af etravirin og lægemidler, der hæmmer CYP3A4, CYP2C9 eller CYP2C19, kan reducere clearance af etravirin og øge plasmakoncentrationen af etravirin.
English: Reproductive system and breast disorders uncommon gynaecomastia
Danish: Det reproduktive system og mammae ikke almindelig gynækomasti
English: INTELENCE and tenofovir can be used without dose adjustments.
Danish: INTELENCE og tenofovir kan anvendes uden dosisjustering.
English: Severe cutaneous adverse reactions have been reported with etravirine.
Danish: Der er rapporteret svære kutane bivirkninger ved etravirin.
English: INTELENCE can be co-administered with paroxetine without dose adjustments.
Danish: INTELENCE kan anvendes sammen med paroxetin uden dosisjustering.
English: Do not use after 8 weeks of first opening the bottle.
Danish: Må ikke anvendes senere end 8 uger efter første åbning af beholderen.
English: - The other ingredients are hypromellose, microcrystalline cellulose, colloidal anhydrous silica,
Danish: - Øvrige indholdsstoffer: hypromellose, mikrokrystallinsk cellulose, kolloid vandfri silica,
English: INTELENCE has not been studied in patients with severe hepatic impairment (Child-Pugh Class C) and is therefore not recommended (see sections 4.2 and 4.4).
Danish: INTELENCE er ikke undersøgt til patienter med svært nedsat leverfunktion (Child-Pugh-klasse C) og bør derfor ikke anvendes (se pkt.
English: Amprenavir/ritonavir and fosamprenavir/ritonavir may require dose reduction when co-administered with INTELENCE.
Danish: Det kan være nødvendigt at reducere dosis af amprenavir/ritonavir og fosamprenavir/ritonavir ved indgift samtidig med INTELENCE.
English: Tablet White to off-white, oval tablet debossed with “T125” on one side and “100” on the other side.
Danish: Tabletter Ovale, hvide eller offwhite tabletter præget med "T125" på den ene side og "100" på den anden side.
English: INTELENCE and azithromycin can be used without dose adjustments.
Danish: INTELENCE og azithromycin kan anvendes uden dosisjustering.
English: Do not use after 6 weeks of first opening the bottle.
Danish: Må ikke anvendes senere end 6 uger efter første åbning af beholderen.
English: R(-) methadone AUC ↔ 1.06 (0.99-1.13) Cmin ↔ 1.10 (1.02-1.19) Cmax ↔ 1.02 (0.96-1.09) S(+) methadone AUC ↔ 0.89 (0.82-0.96) Cmin ↔ 0.89 (0.81-0.98) Cmax ↔ 0.89 (0.83-0.97) etravirine
Danish: R(-) metadon AUC ↔ 1,06 (0,99-1,13) Cmin ↔ 1,10 (1,02-1,19) Cmax ↔ 1,02 (0,96-1,09) S(+) metadon AUC ↔ 0,89 (0,82-0,96) Cmin ↔ 0,89 (0,81-0,98) Cmax ↔ 0,89 (0,83-0,97) etravirin
English: Gastrointestinal very common diarrhoea, nausea disorders common gastrooesophageal reflux disease, vomiting, abdominal pain, abdominal distension, flatulence, gastritis, constipation, dry mouth, stomatitis, lipase increased, blood amylase increased uncommon pancreatitis, haematemesis, retching Hepatobiliary disorders common increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST) uncommon hepatitis, hepatic steatosis, cytolytic hepatitis, hepatomegaly
Danish: Mave-tarm-kanalen meget almindelig diaré, kvalme almindelig gastroøsofageal refluks, opkastning, abdominalsmerter, abdominal distension, flatulens, gastritis, obstipation, mundtørhed, stomatitis, forhøjet lipase, forhøjet amylase i blodet ikke almindelig pankreatitis, hæmatemese, kløgning
English: HIV PIs - Boosted with cobicistat Atazanavir/cobicistat Darunavir/cobicistat
Danish: Boostede hiv-proteasehæmmere med cobicistat Atazanavir/cobicistat
English: INTELENCE 25 mg tablets
Danish: INTELENCE 25 mg tabletter
English: Your doctor will have to check your blood - fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole (medicines to treat fungal infections) - clarithromycin, rifabutin (antibiotics) - artemether/lumefantrine (a medicine to treat malaria) - diazepam (medicines to treat trouble with sleeping and/or anxiety) - dexamethasone (a corticosteroid used in a variety of conditions such as inflammation and allergic reactions) - boceprevir (a medicine to treat hepatitis C infection) - atorvastatin, fluvastatin, lovastatin, rosuvastatin, simvastatin (cholesterol-lowering medicines) - cyclosporine, sirolimus, tacrolimus (immunosuppressants - medicines used to dampen down your immune system) - sildenafil, vardenafil, tadalafil (medicines to treat erectile dysfunction and/or pulmonary arterial hypertension) - clopidogrel (a medicine to prevent blood clots).
Danish: Lægen vil kontrollere dit blod - fluconazol, itraconazol, ketoconazol, posaconazol, voriconazol (til behandling af svampeinfektioner) - clarithromycin, rifabutin (antibiotika) - artemether/lumefantrin (malariamiddel) - diazepam (til behandling af søvnforstyrrelser og/eller angst) - dexamethason (et steroid, som bruges til behandling af mange forskellige tilstande, f.eks.
English: Based on historical data, a decrease in etravirine exposure may be expected whereas an increase in rifabutin exposure and especially in 25-O-desacetyl-rifabutin may be expected.
Danish: Derimod kan der forventes en øget rifabutineksponering, især for 25-O-desacetylrifabutin.
English: INTELENCE and raltegravir can be used without dose adjustments.
Danish: INTELENCE og raltegravir kan anvendes uden dosisjustering.
English: Concomitant use of etravirine with rilpivirine may cause a decrease in the plasma concentration of rilpivirine and loss of therapeutic effect of rilpivirine.
Danish: Samtidig indgift af etravirin og rilpivirin kan forårsage nedsat rilpivirin-plasmakoncentration og manglende terapeutisk virkning af rilpivirin.
English: Rash was mostly self-limiting and generally resolved within 1 to 2 weeks on continued therapy.
Danish: Udslættet var for det meste selvbegrænsende og forsvandt generelt i løbet af 1-2 uger, hvis behandlingen fortsattes.
English: 1 mg once daily ethinylestradiol AUC ↑ 1.22 (1.13-1.31) Cmin ↔ 1.09 (1.01-1.18) Cmax ↑ 1.33 (1.21-1.46) norethindrone AUC ↔ 0.95 (0.90-0.99) Cmin ↓ 0.78 (0.68-0.90) Cmax ↔ 1.05 (0.98-1.12) etravirine
Danish: 1 mg en gang dagligt ethinyløstradiol AUC ↑ 1,22 (1,13-1,31) Cmin ↔ 1,09 (1,01-1,18) Cmax ↑ 1,33 (1,21-1,46) norethindron AUC ↔ 0,95 (0,90-0,99) Cmin ↓ 0,78 (0,68-0,90) Cmax ↔ 1,05 (0,98-1,12) etravirin
English: Non-completer is failure (NC = F) imputation.
Danish: Imputering af manglende gennemførelse svarer til svigt.
English: Medicinal products that induce CYP3A4, CYP2C9 or CYP2C19 may increase the clearance of etravirine, resulting in lowered plasma concentrations of etravirine.
Danish: CYP3A4, CYP2C9 eller CYP2C19, kan øge clearance af etravirin, hvilket kan reducere plasmakoncentrationen af etravirin.
English: INTELENCE and digoxin can be used without dose adjustments.
Danish: INTELENCE og digoxin kan anvendes uden dosisjustering.
English: The combination of etravirine with simeprevir, daclatasvir, atazanavir/cobicistat or darunavir/cobicistat is not recommended (see section 4.5).
Danish: Det frarådes at kombinere etravirin med simeprevir, daclatasvir, atazanavir/cobicistat eller darunavir/cobicistat (se pkt.
English: Silicified microcrystalline cellulose Microcrystalline cellulose Colloidal anhydrous silica Croscarmellose sodium Magnesium stearate
Danish: Silicificeret mikrokrystallinsk cellulose Mikrokrystallinsk cellulose Kolloid vandfri silica Croscarmellosenatrium Magnesiumstearat
English: Each tablet contains 160 mg of lactose monohydrate.
Danish: Hver tablet indeholder 160 mg lactosemonohydrat.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to CART.
Danish: Ætiologien anses dog for at være multifaktoriel (omfattende anvendelse af kortikosteroider, alkoholforbrug, svær immunsuppression, højere body mass index).
English: Etravirine is expected to increase plasma concentrations of warfarin.
Danish: Etravirin forventes at øge plasmakoncentrationen af warfarin.
English: INTELENCE and atazanavir/ritonavir can be used without dose adjustment.
Danish: INTELENCE og atazanavir/ritonavir kan anvendes uden dosisjustering.