FrancophonIA/ELRC3.0 huggingface dataset:
English: Immune Reactivation Syndrome: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Danish: Immunreaktiveringssyndrom: Hos hiv-inficerede patienter med svær immuninsufficiens kan der ved påbegyndelse af antiretroviral kombinationsbehandling (CART) opstå en inflammatorisk reaktion på asymptomatiske eller residuale opportunistiske patogener, som kan forårsage alvorlige kliniske tilstande eller forværring af symptomer.
English: For patients demonstrating a subsequent increase in QT-interval to > 480 msec or increase by > 20 msec after commencing concomitant therapy, the physician should use best clinical judgment to discontinue either ritonavir-boosted Invirase or the concomitant therapy or both.
Danish: For patienter, der efterfølgende viser forlængelse af QTintervallet til > 480 ms eller en forlængelse på >20 ms efter start af samtidig behandling, må lægen efter bedste kliniske dømmekraft afgøre, om enten behandlingen med ritonavirboostet Invirase eller det andet lægemiddel skal ophøre eller om begge skal ophøre.
English: Tacrolimus is a substrate of CYP3A4 and P-glycoprotein.
Danish: Tacrolimus er substrat for CYP3A4 og Pglykoprotein.
English: Kidney disease: Consult your doctor if you have a history of kidney disease.
Danish: Nyresygdom: Kontakt din læge, hvis du har haft en nyresygdom.
English: Concomitant administration of boosted saquinavir and fluticasone propionate and other corticosteroids metabolised via the P450 3A pathway (e.g. budesonide) is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4).
Danish: Samtidig administration af boostet saquinavir og fluticasonpropionat og andre kortikosteroider metaboliseret via P450 3A (f.eks. budesonid) anbefales ikke, medmindre den potentielle fordel ved behandlingen opvejer risikoen for systemiske bivirkninger forårsaget af kortikosteroider (se pkt.
English: Phosphodiesterase type 5 (PDE5) inhibitors Sildenafil (saquinavir/ritonavir) Sildenafil 100 mg (single dose) (unboosted saquinavir 1200 mg tid)
Danish: Phosphodiesterase-type 5-hæmmere (PDE5-hæmmere) - Sildenafil (saquinavir/ritonavir) - Sildenafil 100 mg (enkeltdosis) (ikke-boostet saquinavir 1.200 mg 3 gange daglig)
English: Nervous System Disorder Common
Danish: Nervesystemet Almindelig
English: Table 3: Maximum mean of ddQTcS† (msec) on day 3 for therapeutic dose of Invirase/ritonavir, supra-therapeutic dose of Invirase/ritonavir and active control moxifloxacin in healthy volunteers in Thorough QT (TQT) Study
Danish: Tabel 3: Maksimal gennemsnitlig ddQTcS† (ms) hos raske frivillige på dag 3 for terapeutisk dosis af Invirase/ritonavir, supraterapeutisk dosis af Invirase/ritonavir og aktiv kontrol moxifloxacin i Thorough-QT (TQT) studiet
English: The expiry date refers to the last day of that month.
Danish: Brug ikke Invirase efter den udløbsdato, der står på pakningen efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section
Danish: Vægtstigning og forhøjede lipider og glucose i blodet kan forekomme under antiretroviral behandling (se pkt.
English: Psychiatric Disorders Common
Danish: Psykiske forstyrrelser Almindelig
English: Glucocorticoids: Concomitant use of boosted saquinavir and fluticasone or other glucocorticoids that are metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section 4.5).
Danish: Glukokortikoider: Samtidig brug af boostet saquinavir og fluticason eller andre glukokortikoider, som metaboliseres af CYP3A4, anbefales ikke, med mindre de potentielle fordele ved behandlingen opvejer risikoen for systemiske bivirkninger forårsaget af kortikosteroider, herunder Cushings syndrom og binyrebarksuppression (se pkt.
English: Atorvastatin is less dependent on CYP3A4 for metabolism.
Danish: Atorvastatin er mindre afhængig af CYP3A4 for metabolisme.
English: Oral contraceptives: Because concentration of ethinyl estradiol may be decreased when coadministered with Invirase/ritonavir, alternative or additional contraceptive measures should be used when oestrogen-based oral contraceptives are co-administered (see section 4.5).
Danish: Orale kontraceptiva: Da koncentrationen af ethinylestradiol kan falde hvis det administreres sammen med Invirase/ritonavir, bør der anvendes andre eller ekstra præventionsmidler hvis der samtidigt gives østrogenbaserede orale kontraceptiva (se pkt.
English: Therefore, concomitant use of ritonavir-boosted Invirase with other medicinal products that prolong the QT and/or PR interval is contraindicated.
Danish: Derfor er samtidig anvendelse af ritonavirboostet Invirase og andre lægemidler, som forlænger QT- og/eller PR-intervallet, kontraindiceret.
English: • various steroids - such as dexamethasone, ethinyl estradiol, fluticasone
Danish: • forskellige steroider - såsom dexamethason, ethinylestradiol, fluticason
English: N AUC0-12h
Danish: AUC0-12t
English: Body System Frequency of reaction
Danish: Organklasse Bivirkningsfrekvens
English: Following the modified Invirase/ritonavir regimen, saquinavir exposure during the first week peaked on Day 3 and declined to the lowest exposure on Day 7 with ritonavir induction effects, while Day 14 saquinavir PK parameters (following full doses of Invirase/ritonavir in the second week) approached the range of historical mean values for saquinavir steady-state values in HIV-1 infected patients (Table 9).
Danish: Efter det modificerede Invirase/ritonavir-regime, nåede tilgængeligheden af saquinavir sit maksimum på dag 3 under den første uge og faldt til den laveste tilgængelighed på dag 7 med induktionseffekten af ritonavir, mens saquinavirs farmakokinetiske parametre på dag 14 (efter fuld dosis af Invirase/ritonavir i den anden uge) nærmede sig niveauet for tidligere middelværdier for saquinavirs steady state værdier i hiv-1-inficerede patienter (tabel 9).
English: In patients with haemophilia type A and B, there have been reports of increased bleeding while taking this treatment or another protease inhibitor.
Danish: Hos nogle patienter med hæmofili A og B er der meddelt tilfælde om øget blødningstendens under denne behandling eller behandling med en anden proteasehæmmer.
English: - Delavirdine (unboosted saquinavir)
Danish: - Delavirdin (ikke-boostet saquinavir)
English: • Take your Invirase film-coated tablets with or after food.
Danish: • Tag dine Invirase filmovertrukne tabletter i forbindelse med et måltid
English: Saquinavir AUC ↑ 177 % Saquinavir Cmax ↑ 187 % Clarithromycin AUC ↑ 40 % Clarithromycin Cmax ↑ 40 %
Danish: Saquinavir Cmax ↑ 187 % Clarithromycin AUC ↑ 40 % Clarithromycin Cmax ↑ 40 %.
English: Eye Disorders Uncommon
Danish: Øjne Ikke almindelig
English: Immune System Disorders Common
Danish: Immunsystemet Almindelig
English: Caution should be exercised in patients with severe renal impairment (see section 4.4).
Danish: Der bør udvises forsigtighed hos patienter med svært nedsat nyrefunktion (se pkt.
English: hydroquinidine, ibutilide, lidocaine, propafenone, quinidine, sotalol
Danish: hydrokinidin, ibutilid, lidocain, propafenon, kinidin og sotalol
English: To prevent possible development of rifabutin resistance in TB and HIV co-infected patients, the recommended dose of rifabutin is 150 mg every other day or three times per week, with the dose of saquinavir/ritonavir unchanged (1000/100 mg bid).
Danish: For at forebygge en mulig udvikling af rifabutinresistens hos patienter med TB/hiv-co-infektion anbefales en rifabutindosis på 150 mg hver anden dag eller 3 gange om ugen, mens dosis af saquinavir/ritonavir er uændret (1.000/100 mg 2 gange daglig)
English: Although specific studies have not been performed, co-administration of Invirase/ritonavir with medicinal products that are mainly metabolised by CYP3A4 pathway may result in elevated plasma concentrations of these medicinal products.
Danish: Selvom der ikke er udført specifikke studier, kan samtidig administration af Invirase/ritonavir og lægemidler, som hovedsageligt metaboliseres af CYP3A4, muligvis medføre stigninger i plasmakoncentrationer af disse lægemidler.
English: • other HIV medicines - such as nelfinavir, indinavir, nevirapine, delavirdine, efavirenz, maraviroc,
Danish: • andre lægemidler mod hiv - såsom nelfinavir, indinavir, nevirapin, delavirdin, efavirenz,
English: • certain medicines for depression - amitriptyline, imipramine, trazodone, maprotiline
Danish: • visse lægemidler mod depression - amitriptylin, imipramin, trazodon, maprotilin
English: Paraesthesia, peripheral neuropathy, dizziness, dysgeusia, headache
Danish: Paræstesier, perifer neuropati, svimmelhed, smagsforstyrrelser, hovedpine
English: - Patients demonstrating a subsequent increase in QT-interval to > 480 msec or prolongation over pre-treatment by > 20 msec should discontinue ritonavir-boosted Invirase.
Danish: - Patienter, der efterfølgende viser forlængelse af QT- intervallet til > 480 ms eller en forlængelse i forhold til før behandling på > 20 ms, skal stoppe behandlingen med ritonavirboostet Invirase.
English: Effective therapy in treatment naïve patients is associated with a Cmin of approximately 50 ng/ml and an AUC0-24 of about 20,000 ng·h/ml.
Danish: Effektiv behandling af naive patienter er forbundet med Cmin på ca. 50 ng/ml og en AUC0-24 på omkring 20.000 ng⋅time/ml.
English: -Sildenafil is a substrate of CYP3A4.
Danish: - Sildenafil er et substrat for CYP3A4.
English: Other less frequently reported side effects (in more than one in one thousand persons but less than one in a hundred persons) include: decreased appetite, visual disturbance, inflammation of the liver, fits, allergic reactions, blisters, sleepiness, abnormal renal function, inflammation of the pancreas, yellowing of the skin or whites of the eyes caused by liver problems and Steven's Johnson syndrome (a serious illness with blistering of the skin, eyes, mouth and genitals).
Danish: Andre mindre hyppigt rapporterede bivirkninger (hos flere end 1 ud af 1000, men færre end 1 ud af 100 patienter) er: Nedsat appetit, synsforstyrrelser, leverbetændelse, kramper, allergiske reaktioner, blistre, søvnighed, abnorm nyrefunktion, betændelse i bugspytskirtlen, gulfarvning af huden og det hvide i øjnene pga. leverproblemer samt Stevens-Johnsons syndrom (en alvorlig sygdom med blistre på huden, øjnene, i munden og på kønsdelene).
English: Concomitant use of colchicine and saquinavir/ritonavir is expected to increase plasma levels of colchicine due to P-gp and/or CYP3A4 inhibition by the protease inhibitor.
Danish: Samtidig brug af colchicin og saquinavir/ritonavir forventes at øge plasmakoncentrationen af colchicin på grund af proteasehæmmerens hæmning af P-gp og/eller CYP3A4.
English: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthroses, in haemophilic patients type A and B treated with protease inhibitors (see section 4.4).
Danish: Der er rapporteret om forøget blødning, inklusive spontane hudhæmatomer og hæmartroser hos patienter med hæmofili type A og B, som behandledes med proteasehæmmere (se pkt.
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA
Danish: ENTYDIG IDENTIFIKATOR - MENNESKELIGT LÆSEBARE DATA N/A
English: A limited number of studies have been completed with ritonavir boosted Invirase or ritonavir boosted saquinavir soft capsules.
Danish: Et begrænset antal studier er udført med ritonavirboostet Invirase eller ritonavirboostet saquinavir bløde kapsler.
English: If the combination is considered necessary, monitoring of the saquinavir plasma levels is strongly encouraged (see section
Danish: Hvis denne kombination anses for nødvendig, opfordres der kraftigt til, at saquinavirplasmakoncentrationen monitoreres (se pkt.
English: • certain antibiotics - such as quinupristin/dalfopristin, rifabutin, fusidic acid
Danish: • visse antibiotika - såsom quinipristin/dalfopristin, rifabutin, fusidinsyre,
English: Anticonvulsants - Carbamazepine Phenobarbital Phenytoin (saquinavir/ritonavir)
Danish: Antikonvulsiva - Carbamazepin Phenobarbital Phenytoin (saquinavir/ritonavir)
English: Higher doses of ritonavir have been shown to be associated with an increased incidence of adverse events.
Danish: Det er vist, at højere ritonavirdoser ledsages af flere bivirkninger.
English: Saquinavir is essentially completely metabolised by CYP3A4.
Danish: Saquinavir bliver hovedsageligt komplet metaboliseret af CYP3A4.
English: Use with caution due to possible cardiac arrhythmias.
Danish: Forsigtighed ved kombination på grund af risiko for hjertearytmi.
English: Paediatric population: The safety and activity of saquinavir boosted with ritonavir in HIV-infected patients less than 2 years have not been established.
Danish: Pædiatrisk population: Sikkerheden og virknignen af ritonavirboostet saquinavir hos hiv-inficerede børn under 2 år er ikke klarlagt.
English: Other reported side effects (in more than one in a hundred but less than one in ten persons), which may occur are: rash, itching, eczema and dry skin, hair loss, dry mouth, headache, peripheral neuropathy (a disturbance of the nerves in the feet and hands that may take the form of numbness, pins and needles, shooting or burning pain), weakness, dizziness, libido problems, taste alteration, mouth ulcers, dry lips, abdominal discomfort, indigestion, weight loss,constipation, increased appetite, muscle spasms and shortness of breath.
Danish: Andre rapporterede bivirkninger (hos flere end 1 af 100, men færre end 1 ud af 10 patienter), som kan optræde er: Udslæt, kløen, eksem og tør hud, hårtab, mundtørhed, hovedpine, perifer neuropati (en forstyrrelse af nerverne i hænder og fødder i form af følelsesløshed, prikkende og stikkende fornemmelser og jagende eller brændende smerter), slaphed, svimmelhed, libidoproblemer, smagsforstyrrelser, sår i munden, tørre læber, mavebesvær, fordøjelsesbesvær, vægttab, forstoppelse, øget appetit, muskelkramper og åndenød.
English: For zidovudine (200 mg every 8 hours) a 25 % decrease in AUC was reported when combined with ritonavir (300 mg every 6 hours).
Danish: Når zidovudin (200 mg hver 8. time) blev kombineret med ritonavir (300 mg hver 6. time), blev der rapporteret om et 25 % fald i zidovudins AUC.
English: Saquinavir AUC ↓ 15% Saquinavir Cmax ↓ 9% Saquinavir Cmin ↓ 24% (remained above the target threshold for effective therapy.)
Danish: Saquinavir AUC ↓ 15 % Saquinavir Cmax ↓ 9 % Saquinavir Cmin ↓ 24 % (forblev over den terapeutiske tærskel for effektiv behandling)
English: Ergot alkaloids (e.g. ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (saquinavir/ritonavir)
Danish: Sekalealkaloider (f.eks. ergotamin, dihydroergotamin, ergonovin og methylergonovin) (saquinavir/ritonavir)
English: • certain heart medicines - amiodarone, bepridil, disopyramide, dofetilide, flecainide,
Danish: • visse former for hjertemedicin - amiodaron, bepridil, disopyramid, dofetilid, flecainid,
English: Vomiting, abdominal distension, abdominal pain, upper abdominal pain, constipation, dry mouth, dyspepsia, eructation, flatulence, lip dry, loose stools
Danish: Opkastning, abdominal udspilning, abdominalsmerter, øvre abdominalsmerter, forstoppelse, mundtørhed, dyspepsi, opstød, flatulens, tørre læber, løs afførring
English: Patients with hepatic impairment: The effect of hepatic impairment on the steady state pharmacokinetics of saquinavir/ritonavir (1000 mg/100 mg twice daily for 14 days) was investigated in 7 HIV-infected patients with moderate liver impairment (Child Pugh Grade B score 7 to 9).
Danish: Patienter med nedsat leverfunktion: Effekten af nedsat leverfunktion på steady state farmakokinetikken af saquinavir/ritonavir (1.000 mg/100 mg 2 gange daglig i 14 dage) blev undersøgt hos 7 hiv-inficerede patienter med moderat nedsat leverfunktion (Child Pugh klasse B score på 7 til 9).
English: In this study, PR interval of > 200 msec was also observed in 40% and 47% of subjects receiving Invirase/ritonavir 1000/100 mg twice daily and 1500/100 mg twice daily, respectively, on Day 3.
Danish: I dette studie blev der også observeret PR-interval på > 200 ms hos 40 % og 47 % af forsøgspersonerne, som på dag 3 fik Invirase/ritonavir henholdsvis 1.000/100 mg 2 gange daglig og 1.500/100 mg 2 gange daglig.
English: Digoxin 0.5 mg single dose (saquinavir/ritonavir
Danish: Digoxin 0,5 mg enkeltdosis (saquinavir/ritonavir
English: 6.4 Special precautions for storage This medicinal product does not require any special storage conditions.
Danish: Dette lægemiddel kræver ingen særlige forholdsregler vedrørende opbevaringen.
English: Day 7
Danish: Dag 7
English: Saquinavir AUC ↓ 51 % Saquinavir Ctrough ↓ 49 % (8 hours post dose)
Danish: - Saquinavir AUC ↓ 51 % Saquinavir Ctrough ↓ 49 % (8 timer efter indtagelse)
English: Systemic clearance of saquinavir was high, 1.14 l/h/kg (CV 12 %), slightly above the hepatic plasma flow, and constant after intravenous doses of 6, 36 and 72 mg.
Danish: Systemisk clearance af saquinavir var høj, 1,14 l/h/kg (CV 12 %), lidt over leverens plasmagennemstrømning og konstant efter intravenøse doser på 6, 36 og 72 mg. Middeltiden saquinavir er til stede fandtes at være 7 timer (n = 8).
English: If concomitant use is deemed necessary because the potential benefit to the patient outweighs the risk, particular caution is warranted (see section 4.4; for information on individual drugs, see Table 1).
Danish: Hvis samtidig brug anses for at være nødvendig, fordi den potentielle fordel for patienten opvejer risikoen,er særlig forsigtighed påkrævet (se pkt.
English: Interaction with HMG-CoA reductase inhibitors: Caution must be exercised if Invirase/ritonavir is used concurrently with atorvastatin, which is metabolised to a lesser extent by CYP3A4.
Danish: Interaktion med HMG-CoA-reduktasehæmmere: Der skal udvises forsigtighed hvis Invirase/ritonavir anvendes samtidig med atorvastatin, som i mindre udstrækning metaboliseres af CYP3A4, og det bør overvejes at reducere dosis af atorvastatin.
English: Paediatric population:
Danish: Pædiatrisk population
English: The pharmacokinetics of ritonavir remained unchanged.
Danish: Ritonavirs farmakokinetik blev ikke påvirket.
English: • medicines for gout, such as colchicine
Danish: • lægemidler mod urinsyregigt - såsom colchicin
English: Plasma levels of unboosted saquinavir can be reduced by concomitant use of the herbal preparation St. John's wort (Hypericum perforatum).
Danish: - Plasmakoncentrationen af ikke-boostet saquinavir kan reduceres ved samtidigt brug af naturlægemidletperikon (Hypericum perforatum).
English: Invirase is prescribed for use in combination with ritonavir (Norvir) and other antiretroviral medicines.
Danish: Invirase skal anvendes sammen med ritonavir (Norvir) samt andre antiretrovirale lægemidler.
English: What Invirase contains
Danish: Invirase indeholder:
English: Day 14
Danish: Dag 14
English: Therefore, no initial dose adjustment is necessary for patients with renal impairment.
Danish: Derfor er initial dosisjustering ikke nødvendig hos patienter med nedsat nyrefunktion.
English: Pharmaco-therapeutic group: Antiviral agent, ATC code J05A E01
Danish: FARMAKOLOGISKE EGENSKABER 5.1 Farmakodynamiske egenskaber Farmakoterapeutisk klassifikation: Antiviralt middel, ATC kode J05AE01.
English: QT and PR prolongation on electrocardiogram: The effects of therapeutic (1000/100 mg twice daily) and supra-therapeutic (1500/100 mg twice daily) doses of Invirase/ritonavir on the QT interval were evaluated in a 4-way crossover, double-blind, placebo- and active-controlled (moxifloxacin 400 mg) study in healthy male and female volunteers aged 18 to 55 years old (N=59).
Danish: QT- og PR-forlængelse i elektrokardiogram: Effekten af terapeutiske (1.000/100 mg 2 gange daglig) og supraterapeutiske (1.500/100 mg 2 gange daglig) doser af Invirase/ritonavir på QT-intervallet blev evalueret i et 4-vejs crossover, dobbeltblindet, placebo- og aktivt kontrolleret (moxifloxacin 400 mg) studie med raske mandlige og kvindelige frivillige i alderen 18 til 55 år (N=59).
English: Invirase 500 mg film-coated tablets Saquinavir
Danish: Invirase 500 mg filmovertrukne tabletter Saquinavir
English: Saquinavir levels may increase on stopping St. John's wort, and the dose of saquinavir may need adjusting.
Danish: Saquinavirkoncentrationer kan stige ved ophør med perikon og det kan blive nødvendigt at justere saquinavirdosis.
English: Effective therapy in treatment experienced patients is associated with a Cmin of approximately 100 ng/ml and an AUC0-24 of about 20,000 ng·h/ml.
Danish: Effektiv behandling af behandlingserfarne patienter er forbundet med en Cmin på ca. 100 ng/ml og en AUC0-24 på omkring 20.000 ng⋅time/ml.
English: Invirase should only be given in combination with ritonavir and other antiretroviral medicinal products (see section 4.2).
Danish: Invirase må kun gives i kombination med ritonavir og andre antiretrovirale lægemidler (se pkt.
English: Invirase comes as a 500 mg film-coated tablet.
Danish: Invirase leveres som en 500 mg filmovertrukken tablet.
English: Itraconazole is a moderately potent inhibitor of CYP3A4.
Danish: - Itraconazol er en moderat potent hæmmer af CYP3A4.
English: Concomitant use of ritonavir-boosted Invirase with other medicinal products that prolong the QT and/or PR interval is therefore contraindicated (see section 4.3).
Danish: Samtidig anvendelse af ritonavirboostet Invirase og andre lægemidler, som forlænger QT- og/eller PR-intervallet, er derfor kontraindiceret (se pkt.
English: Invirase/ritonavir should be administered with or after food.
Danish: Invirase/ritonavir kan administreres med eller uden samtidig fødeindtagelse.
English: - For patients with a baseline QT interval < 450 msec, an on-treatment ECG should be performed.
Danish: 4.5) - For patienter med baseline QT-interval < 450 ms bør der tages et opfølgende ekg under behandlingen.
English: Other medicines and Invirase Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Danish: Fortæl altid lægen eller apotekspersonalet, hvis du bruger anden medicin eller har gjort det for nylig.
English: If a patient is already taking St. John's wort, stop St. John's wort, check viral levels and if possible saquinavir levels.
Danish: Hvis patienten allerede tager perikon, skal brug af perikon ophøre og virusmængden og, om muligt, saquinavirkoncentrationer kontrolleres.
English: UNIQUE IDENTIFIER - 2D BARCODE Not applicable
Danish: ENTYDIG IDENTIFIKATOR - 2D -STREGKODE N/A
English: After 7 days, the recommended dose of Invirase is 1000 mg two times daily with ritonavir 100 mg two times daily in combination with other antiretroviral agents.
Danish: Efter 7 dage er den anbefalede dosis af Invirase 1.000 mg 2 gange daglig med 100 mg ritonavir 2 gange daglig i kombination med andre antiretrovirale stoffer.
English: Nucleoside reverse transcriptase inhibitors (NRTIs) - Zalcitabine and/or
Danish: Nukleosid reverse transkriptasehæmmere (NRTIs) - Zalcitabin og/eller zidovudin
English: Dizziness, fatigue and visual impairment have been reported during treatment with Invirase.
Danish: Der er blevet rapporteret om svimmelhed, træthed og synsnedsættelse under behandling med Invirase.
English: • This medicine has been prescribed for you only.
Danish: • Lægen har ordineret Invirase til dig personligt.
English: Rifampicin is contraindicated in combination with Invirase/ritonavir (see section 4.3).
Danish: Rifampicin er kontraindiceret i kombination med Invirase/ritonavir (se pkt.
English: SQV Naive/Experienced Population
Danish: RESIST 1 & 2 SQV Naiv/Tidligere behandlet population
English: Both drugs are CYP3A4 inhibitors and may increase the plasma concentration of saquinavir.
Danish: Begge lægemidler er CYP3A4 hæmmere og kan øge plasmakoncentrationen af saquinavir.