FrancophonIA/ELRC3.0 huggingface dataset:
English: When measured by ambulatory blood pressure monitoring, the trough to peak effects of CoAprovel 150 mg/12.5 mg were 100%.
Maltese: Meta mkejla permezz ta' osservazzjoni tal-pressjoni ambulatorja l-effetti mill-inqas għal aktar ta' CoAprovel 150 mg/12.5 mg kienu 100%.
English: CoAprovel 300 mg/12.5 mg tablets are supplied in blister packs of 14, 28, 56 or 98 tablets.
Maltese: Il-pilloli CoAprovel 300 mg/12.5 mg huma pprovduti f'pakketti f'folji ta' 14, 28, 56 jew 98 pillola.
English: Each tablet contains: irbesartan 150 mg and hydrochlorothiazide 12.5 mg
Maltese: Kull pillola fiha: irbesartan 150 mg u hydrochlorothiazide 12.5 mg
English: Cartons of 56 tablets in PVC/PVDC/Aluminium blisters.
Maltese: Pakketti ta' 56 pillola f'folji tal-PVC/PVDC/Aluminju.
English: How to take CoAprovel
Maltese: X'fih CoAprovel
English: Older people
Maltese: TA' EĊĊIPJENTI
English: flushing
Maltese: fwawar
English: Dosage
Maltese: Is-Sibt
English: 30-36 Avenue Gustave Eiffel
Maltese: Sanofi Winthrop Industrie 30-36, avenue Gustave Eiffel 37100 Tours
English: Lactose: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Maltese: Pazjenti bi problemi ereditarji rari ta' intolleranza għall-galactose, nuqqas totali ta' lactase jew assorbiment ħażin tal-glucose-galactose m'għandhomx jieħdu dan il-prodott mediċinali.
English: Each film-coated tablet contains 53.3 mg of lactose (as lactose monohydrate).
Maltese: Kull pillola miksija b'rita fiha 53.3 mg ta' lactose (bħala lactose monohydrate).
English: EU/1/98/086/007 - 14 tablets EU/1/98/086/001 - 28 tablets EU/1/98/086/002 - 56 tablets EU/1/98/086/009 - 56 x 1 tablets EU/1/98/086/003 - 98 tablets
Maltese: EU/1/98/086/007 - 14-il pillola EU/1/98/086/001 - 28 pillola EU/1/98/086/002 - 56 pillola EU/1/98/086/009 - 56 x 1 pillola EU/1/98/086/003 - 98 pillola
English: Additional information on hydrochlorothiazide interactions: when administered concurrently, the following medicinal products may interact with thiazide diuretics:
Maltese: Tagħrif addizzjonali dwar l-effetti ta' hydrochlorothiazide ma' mediċini oħra: meta jingħataw flimkien, il-prodotti mediċinali segwenti jistgħu jinteraġixxu ma' dijuretiċi thiazide:
English: Renal artery stenosis - Renovascular hypertension: there is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists.
Maltese: Stenożi ta' l-arterja renali - Pressjoni għolja renovaskulari: hemm riskju ikbar ta' pressjoni baxxa severa u ta' insuffiċjenza renali meta pazjenti li għandhom stenożi bilaterali ta' l-arterja renali, jew stenożi ta' l-arterja li tagħti għall-kilwa waħda taħdem, jiġu kkurati b'impedituri ta' l-enzima li tikkonverti l-angiotensin jew b' antagonisti tar-riċetturi angiotensin-II.
English: dizziness
Maltese: irrekwitezza
English: Most of the above mentioned effects appear to be due to the pharmacological activity of irbesartan (blockade of angiotensin-II-induced inhibition of renin release, with stimulation of the renin-producing cells) and occur also with angiotensin converting enzyme inhibitors.
Maltese: Il-parti l-kbira mill-effetti msemmija hawn fuq jidhru li ġraw minħabba l-attività farmakoloġika ta' irbesartan (imblokk ta' l-inibizzjoni stimulata minn angiotensin-II tal-ħelsien ta' renin, b'stimulazzjoni ta' ċelluli li jipproduċu renin) u jseħħu wkoll b'impedituri ta' enzimi li jikkonvertu angiotensin.
English: Dual blockade of the renin-angiotensin-aldosterone system (RAAS): there is evidence that the concomitant use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure).
Maltese: Imblokk doppju tas-sistema tar-renin-angiotensin-aldosterone (RAAS - renin-angiotensin-aldosterone system): hemm evidenza li l-użu fl-istess ħin ta' inibituri ta' ACE, imblokkaturi tar-riċetturi ta' angiotensin II jew aliskiren iżid ir-riskju ta' pressjoni baxxa, iperkalimja u tnaqqis fil-funzjoni talkliewi (li jinkludi insuffiċjenza akuta tal-kliewi).
English: pancreatitis, anorexia, diarrhoea, constipation, gastric irritation, sialadenitis, loss of appetite
Maltese: Mhux magħrufa: pankrejatite, anoressja, dijarea, stitikezza, irritazzjoni fl-istonku, sijaladenite, nuqqas ta' aptit
English: transient blurred vision, xanthopsia, acute myopia and secondary acute angle-closure glaucoma
Maltese: Mhux magħrufa: vista mċajpra li tgħaddi, xanthopsia, mijopija akuta u glawkoma akuta sekondarja ta' għeluq tal-angolu
English: Cartons of 14 tablets in PVC/PVDC/Aluminium blisters.
Maltese: Pakketti ta' 14-il pillola f'folji tal-PVC/PVDC/Aluminju.
English: vertigo, paraesthesia, light-headedness, restlessness
Maltese: Mhux magħrufa: vertigo, parasteżija, sturdament,
English: Hypersensitivity to the active substances or to any of the excipients listed in section 6.1, or to other sulfonamide-derived substances (hydrochlorothiazide is a sulfonamide-derived substance) Second and third trimesters of pregnancy (see sections 4.4 and 4.6) Severe renal impairment (creatinine clearance < 30 ml/min) Refractory hypokalaemia, hypercalcaemia
Maltese: It-tieni u t-tielet trimestru tat-tqala (ara sezzjonijiet 4.4 u 4.6) Indeboliment renali sever (tneħħija tal-krejatinina < 30 ml/min) Ipokalimja rifrattorja, iperkalċimja
English: Each tablet contains: irbesartan 300 mg and hydrochlorothiazide 12.5 mg
Maltese: Kull pillola fiha: irbesartan 300 mg u hydrochlorothiazide 12.5 mg
English: Limited clinical data (7 out of 22 patients) suggest that patients not controlled with the 300 mg/12.5 mg combination may respond when uptitrated to 300 mg/25 mg.
Maltese: Dejta klinika limitata (7 minn 22 pazjent) tissuġġerixxi li l-pazjenti mhux ikkontrollati bil-kombinazzjoni ta' 300 mg/12.5 mg jistgħu jiġu titrati ‘l fuq għal 300 mg/25 mg.
English: Each tablet of CoAprovel 150 mg/12.5 mg contains 150 mg irbesartan and 12.5 mg hydrochlorothiazide.
Maltese: CoAprovel 150 mg/12.5 mg fiha 150 mg irbesartan u 12.5 mg hydrochlorothiazide.
English: CoAprovel 150 mg/12.5 mg tablets irbesartan/hydrochlorothiazide
Maltese: Pilloli CoAprovel 150 mg/12.5 mg irbesartan/hydrochlorothiazide
English: EU/1/98/086/004-006 EU/1/98/086/008 EU/1/98/086/010
Maltese: EU/1/98/086/008 EU/1/98/086/010
English: Losartan
Maltese: sturdament
English: CoAprovel 300 mg/12.5 mg tablets irbesartan/hydrochlorothiazide
Maltese: Pilloli CoAprovel 300 mg/12.5 mg irbesartan/hydrochlorothiazide
English: CoAprovel 150 mg/12.5 mg film-coated tablets are supplied in blister packs of 14, 28, 30, 56, 84, 90 or 98 film-coated tablets.
Maltese: Il-pilloli miksijin b'rita CoAprovel 150 mg/12.5 mg huma fornuti fi strixxi ta' 14, 28, 30, 56, 84, 90 jew 98 pillola miksija b'rita.
English: When irbesartan is administered concomitantly with a low dose of hydrochlorothiazide (e.g. 12.5 mg daily), the antihypertensive response in black patients approaches that of non-black patients.
Maltese: Meta irbesartan jingħata flimkien ma' doża baxxa ta' hydrochlorothiazide (p.e 12.5 mg kuljum), ir-rispons kontra il-pressjoni għolja f'pazjenti suwed javviċina lil dak f'pazjenti mhux suwed.
English: EU/1/98/086/023 - 14 tablets EU/1/98/086/024 - 28 tablets EU/1/98/086/031 - 30 tablets EU/1/98/086/025 - 56 tablets EU/1/98/086/028 - 56 x 1 tablets EU/1/98/086/026 - 84 tablets EU/1/98/086/034 - 90 tablets EU/1/98/086/027 - 98 tablets
Maltese: EU/1/98/086/023 - 14-il pillola EU/1/98/086/024 - 28 pillola EU/1/98/086/031 - 30 pillola EU/1/98/086/025 - 56 pillola EU/1/98/086/028 - 56 x 1 pillola EU/1/98/086/026 - 84 pillola EU/1/98/086/034 - 90 pillola EU/1/98/086/027 - 98 pillola
English: Potassium-sparing diuretics, potassium supplements or potassium-containing salts substitutes should be co-administered cautiously with CoAprovel (see section 4.5).
Maltese: Id-dijuretiċi li ma jnaqqsux il-potassium, supplimenti tal-potassium jew sostituti li fihom il-potassium għandhom jingħataw b'attenzjoni flimkien ma' CoAprovel (ara sezzjoni 4.5).
English: The use of HCTZ may also need to be reconsidered in patients who have experienced previous NMSC (see also section 4.8).
Maltese: L-użu ta' HCTZ jista' jkun li jrid jerġa' jiġi kkunsidrat f'pazjenti li esperjenzaw NMSC qabel (ara wkoll sezzjoni 4.8).
English: CoAprovel should not be used in patients with severe renal impairment (creatinine clearance < 30 ml/min) (see section 4.3).
Maltese: CoAprovel m'għandux jintuża f'pazjenti b'indeboliment renali sever (tneħħija tal-krejatinina < 30 ml/min) (ara sezzjoni 4.3).
English: Anticholinergic agents (e.g. atropine, beperiden) may increase the bioavailability of thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate.
Maltese: Il-mediċini antikolinerġiċi (p.e atropine, beperiden) jistgħu jżidu l-biodisponibilità tad-dijuretiċi tat-tip thiazide billi jnaqqsu l-motilità gastro-intestinali u r-rata ta' tbattil ta' l-istonku.
English: ANNEX II
Maltese: Il-Ħadd
English: Cartons of 28 tablets in PVC/PVDC/Aluminium blisters.
Maltese: Pakketti ta' 28 pillola f'folji tal-PCV/PVDC/Aluminju.
English: Medicinal products affecting potassium: the potassium-depleting effect of hydrochlorothiazide is attenuated by the potassium-sparing effect of irbesartan.
Maltese: Prodotti mediċinali li jaffettwaw il-potassium: l-effett fit-tnaqqis ta' potassium ikkaġunat minn hydrochlorothiazide jonqos minħabba l-effett potassium-sparing ta'irbesartan.
English: thrombocytopenia
Maltese: Qalba tal-pillola:
English: You may need to have blood checks if you take: potassium supplements salt substitutes containing potassium potassium sparing medicines or other diuretics (water tablets) some laxatives medicines for the treatment of gout therapeutic vitamin D supplements medicines to control heart rhythm medicines for diabetes (oral agents or insulins) carbamazepine (a medicine for the treatment of epilepsy).
Maltese: Jista' jkollok bżonn tagħmel xi kontroll tad-demm jekk tieħu: supplimenti tal-potassium sostituti tal-melħ li fihom il-potassium mediċini li fihom il-potassium, dijuretiċi oħra (pilloli ta' l-ilma) xi lassattivi mediċini għall-kura tal-gotta supplimenti terapewtiċi tal-vitamina D mediċini biex jikkontrolaw ir-ritmu tal-qalb mediċini għad-dijabete (mediċini li jittieħdu mill-ħalq jew insulina) carbamazepine (mediċina għall-kura tal-epilessija).
English: EU/1/98/086/011-015 EU/1/98/086/021 EU/1/98/086/029 EU/1/98/086/032
Maltese: EU/1/98/086/021 EU/1/98/086/029 EU/1/98/086/032
English: Acute Myopia and Secondary Acute Angle-Closure Glaucoma: sulfonamide drugs or sulfonamide derivative drugs can cause an idiosyncratic reaction, resulting in transient myopia and acute angleclosure glaucoma.
Maltese: Mijopija Akuta u Glawkoma Akuta Sekondarja ta' Għeluq tal-Angolu: mediċini li fihom sulfonamide jew derivat ta' sulfonamide, jistgħu jikkawżaw reazzjoni idjosinkratika, u dan jista' jirriżulta f'mijopija temporanja u glawkoma akuta ta' għeluq tal-angolu.
English: EU/1/98/086/011 - 14 tablets EU/1/98/086/012 - 28 tablets EU/1/98/086/029 - 30 tablets EU/1/98/086/013 - 56 tablets EU/1/98/086/014 - 56 x 1 tablets EU/1/98/086/021 - 84 tablets EU/1/98/086/032 - 90 tablets EU/1/98/086/015 - 98 tablets
Maltese: EU/1/98/086/011 - 14-il pillola EU/1/98/086/012 - 28 pillola EU/1/98/086/029 - 30 pillola EU/1/98/086/013 - 56 pillola EU/1/98/086/014 - 56 x 1 pillola EU/1/98/086/021 - 84 pillola EU/1/98/086/032 - 90 pillola EU/1/98/086/015 - 98 pillola
English: CoAprovel 300 mg/25 mg film-coated tablets are supplied in blister packs of 14, 28, 30, 56, 84, 90 or 98 film-coated tablets.
Maltese: Il-pilloli miksijin b'rita CoAprovel 300 mg/25 mg huma fornuti fi strixxi ta' 14, 28, 30, 56, 84, 90 jew 98 pillola miksija b'rita.
English: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Maltese: Neoplażmi beninni, malinni u dawk mhux speċifikati (inklużi ċesti u polipi):
English: EU/1/98/086/016 - 14 tablets EU/1/98/086/017 - 28 tablets EU/1/98/086/030 - 30 tablets EU/1/98/086/018 - 56 tablets EU/1/98/086/019 - 56 x 1 tablets EU/1/98/086/022 - 84 tablets EU/1/98/086/033 - 90 tablets EU/1/98/086/020 - 98 tablets
Maltese: EU/1/98/086/016 - 14-il pillola EU/1/98/086/017 - 28 pillola EU/1/98/086/030 - 30 pillola EU/1/98/086/018 - 56 pillola EU/1/98/086/019 - 56 x 1 pillola EU/1/98/086/022 - 84 pillola EU/1/98/086/033 - 90 pillola EU/1/98/086/020 - 98 pillola
English: Irbesartan/hydrochlorothiazide combination
Maltese: L-għoti ta' irbesartan/hydrochlorothiazide flimkien
English: Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnaesemia.
Maltese: Ġie muri li thiazides iżidu t-tneħħija urinarja tal-magnesium, li tista' twassal f'ipomagneżimja.
English: Sat
Maltese: TIKKETTAR
English: In non-clinical safety studies, high doses of irbesartan (≥ 250 mg/kg/day in rats and ≥ 100 mg/kg/day in macaques) caused a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit).
Maltese: Fi studji mhux kliniċi ta' sigurtà, dożi għoljin ta' irbesartan (≥ 250 mg/kg/jum f'firien u ≥ 100 mg/kg/jum f'makakki) ikkawżaw tnaqqis fil-parametri taċ-ċelluli ħomor tad-demm (eritroċiti, emoglobina, ematokrit).
English: Each tablet of CoAprovel 300 mg/12.5 mg contains 300 mg irbesartan and 12.5 mg hydrochlorothiazide.
Maltese: CoAprovel 300 mg/12.5 mg fiha 300 mg irbesartan u 12.5 mg hydrochlorothiazide.
English: Cartons of 98 tablets in PVC/PVDC/Aluminium blisters.
Maltese: Pakketti ta' 98 pillola; f'folji tal-PVC/PVDC/Aluminju.
English: Available pharmacodynamic/toxicological data in rats have shown excretion of irbesartan or its metabolites in milk (for details see 5.3).
Maltese: Dejta farmakodinamika / tossikoloġika fil-firien uriet li kien hemm eliminazzjoni ta' irbesartan jew il-metaboliti tiegħu fil-ħalib tas-sider (gћad-dettalji ara 5.3).
English: Pink, biconvex, oval-shaped, with a heart debossed on one side and the number 2788 engraved on the other side.
Maltese: Roża, ibbuzzata fuq iż-żewġ naħat, ovali, b'qalb ibbuzzata fuq naħa waħda u numru 2788 mnaqqax fuq in-naħa l-oħra.
English: impaired renal function including isolated cases of renal failure in patients at risk (see section 4.4)
Maltese: tneħħi l-awrina b'mod anormali Mhux magħrufa: funzjoni renali indebolita inkluż każijiet iżolati ta' kollass renali f'pazjenti f'riskju (ara sezzjoni 4.4)
English: CoAprovel 300 mg/12.5 mg film-coated tablets are supplied in blister packs of 14, 28, 30, 56, 84, 90 or 98 film-coated tablets.
Maltese: Il-pilloli miksijin b'rita CoAprovel 300 mg/12.5 mg huma fornuti fi strixxi ta' 14, 28, 30, 56, 84, 90 jew 98 pillola miksija b'rita.
English: Common side effects (may affect up to 1 in 10 people): nausea/vomiting abnormal urination fatigue dizziness (including when getting up from a lying or sitting position) blood tests may show raised levels of an enzyme that measures the muscle and heart function (creatine kinase) or raised levels of substances that measure kidney function (blood urea nitrogen, creatinine).
Maltese: Effetti sekondarji komuni (jistgħu jaffettwaw sa persuna waħda minn kull 10) dardir/rimettar tagħmel l-awrina mhux normali għeja sturdament (anki meta tqum minn mimdud jew minn bil-qiegħda) testijiet tad-demm jistgħu juru livelli ogħla ta' enzim li jkejjel il-funzjoni tal-muskoli u tal-qalb (creatine kinase) jew livelli għoljin ta' sustanzi li jkejlu l-funzjoni tal-kliewi (nitroġenu fl-urea tad-demm, creatinine).
English: Ear and labyrinth disorders:
Maltese: Disturbi fil-widnejn u fis-sistema labirintika:
English: See also information under the heading “Do not take CoAprovel”.
Maltese: Ara wkoll l-informazzjoni taħt l-intestatura “Tiħux CoAprovel”
English: Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists.
Maltese: Irbesartan jappartjeni għall-grupp ta' mediċini magħrufin bħala antagonisti tar-riċetturi angiotensin-II.
English: Linearity/non-linearityIrbesartan exhibits linear and dose proportional pharmacokinetics over the dose range of 10 to 600 mg. A less than proportional increase in oral absorption at doses beyond 600 mg was observed; the mechanism for this is unknown.
Maltese: Ġiet osservata żieda mhux proporzjonali, fl-assorbiment mill-ħalq meta tingħata doża iktar minn 600 mg; dan il-mekkaniżmu għadu mhux magħruf.
English: CoAprovel 300 mg/25 mg film-coated tablets irbesartan/hydrochlorothiazide
Maltese: TAL-PRODOTT MEDIĊINALI CoAprovel 300 mg/25 mg pilloli irbesartan/hydrochlorothiazide ISEM
English: PC: SN: NN:
Maltese: Mhux magħrufa: tinnitus
English: There is no clinical experience with CoAprovel in patients with hepatic impairment.
Maltese: Għad m'hemmx esperjenza klinika b'CoAprovel f'pazjenti b'indeboliment epatiku.
English: Due to the hydrochlorothiazide component, CoAprovel is not recommended for patients with severe renal dysfunction (creatinine clearance < 30 ml/min).
Maltese: Minħabba li fih il-komponent ta' hydrochlorothiazide, CoAprovel mhux irrikmandat għall-pazjenti b'disfunzjoni renali severa (tneħħija tal-krejatinina < 30 ml/min).
English: The potential toxicity of the irbesartan/hydrochlorothiazide combination after oral administration was evaluated in rats and macaques in studies lasting up to 6 months.
Maltese: It-tossiċità potenzjali tal-kombinazzjoni ta' irbesartan/hydrochlorothiazide wara li tingħata mill-ħalq ġiet evalwata f'firien u f'makakki (macaques) waqt studji li damu sa 6 xhur.
English: Renal impairment and kidney transplantation: when CoAprovel is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid serum levels is recommended.
Maltese: Indeboliment renali u trapjant tal-kliewi: meta CoAprovel jintuża f'pazjenti b'indeboliment talfunzjoni renali, hija rrikmandata osservazzjoni perjodika tal-livelli tal-potassium fis-serum, tal-krejatinina u tal-uric acid.
English: Cartons of 56 x 1 film-coated tablets in PVC/PVDC/Aluminium perforated unit dose blisters.
Maltese: Pakketti ta' 56 x 1 pillola miksija b'rita kull waħda f'folji tal-PVC/PVDC/Aluminju perforati ta' doża waħda.
English: Polska sanofi-aventis Sp. z o.o.
Maltese: Polska sanofi-aventis Sp. z o.o. Tel.: +48 22 280 00 00
English: Ireland sanofi-aventis Ireland Ltd. T/A SANOFI Tel: +353 (0) 1 403 56 00
Maltese: Slovenija sanofi-aventis d.o.o. Tel: +386 1 560
English: Table 3: Adverse reactions reported with the use of hydrochlorothiazide alone
Maltese: Mhux magħruf Reazzjoni anafilattika inkluż xokk anafilattiku Tabella 3: Reazzjonijiet avversi rapportati ma' l-użu ta' hydrochlorothiazide waħdu
English: Exposure to AIIRA therapy during the second and third trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia).
Maltese: Espożizzjoni għal terapija AIIRA matul it-tieni u t-tielet trimestri hija magħrufa li twassal għal tossiċità tal-fetu uman (tnaqqis fil-funzjoni tal-kliewi, oligohydramnios, tnaqqis fl-ossifikazzjoni tal-għadam tar-ras) u tossiċità neonatali (nuqqas fil-funzjoni tal-kliewi, pressjoni baxxa, iperkalemija) (Ara sezzjoni 5.3).
English: No dosage adjustment of CoAprovel is necessary in patients with mild to moderate hepatic impairment (see section 4.3).
Maltese: M'hemmx bżonn aġġustar fid-doża ta' CoAprovel f'pazjenti b'indeboliment epatiku minn ħafif sa moderat (ara sezzjoni 4.3).
English: Uncommon side effects (may affect up to 1 in 100 people): diarrhoea low blood pressure fainting heart rate increased flushing swelling sexual dysfunction (problems with sexual performance) blood tests may show lowered levels of potassium and sodium in your blood.
Maltese: Effetti sekondarji mhux komuni (jistgħu jaffettwaw sa persuna waħda minn kull 100) dijarea pressjoni baxxa ħass ħażin taħbit mgħaġġel tal-qalb fwawar nefħa disturb sesswali (problemi fl-attività sesswali) testijiet tad-demm jistgħu juru livelli aktar baxxi ta' potassium u sodium fid-demm tiegħek.
English: Thu
Maltese: It-Tnejn
English: Two large randomised, controlled trials (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)) have examined the use of the combination of an ACE-inhibitor with an angiotensin II receptor blocker.
Maltese: Żewġ provi kbar, ikkontrollati, li fihom il-parteċipanti ntgħażlu b'mod każwali (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) u VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)) eżaminaw l-użu tal-kombinazzjoni ta' inibitur ta' ACE flimkien ma' imblokkatur tar-riċetturi ta' angiotensin II. ONTARGET kien studju li twettaq f'pazjenti bi storja medika ta' mard kardjovaskulari jew ċerebrovaskulari, jew dijabete mellitus tip 2 akkumpanjat minn evidenza ta' ħsara fl-organu aħħari. VA NEPHRON-D kien studju li twettaq f'pazjenti b'dijabete mellitus tip 2 u nefropatija dijabetika.
English: Co-administration of thiazide diuretics may increase the incidence of hypersensitivity reactions to allopurinol;
Maltese: L-użu flimkien ta' dijuretiċi thiazide jistgħu jżidu l-inċidenza ta' reazzjonijiet ta' sensittività eċċessiva għal-allopurinol;
English: cases of hypersensitivity reactions such as angioedema, rash, urticaria
Maltese: Mhux magħrufa: każijiet rari ta' reazzjonijiet ta' sensittività eċċessiva bħal anġjoedema, raxx, urtikarja
English: Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Maltese: Sakemm terapija b'AIIRA ma tkunx meqjusa essenzjali, il-pazjenti li jkunu qegħdin jippjanaw li joħorġu tqal għandhom jinqalbu għal trattamenti ta' kontra pressjoni għolja alternattivi li għandhom profil ta' sigurtà stabbilit sabiex jintużaw waqt it-tqala.
English: With hydrochlorothiazide, onset of diuresis occurs in 2 hours, and peak effect occurs at about 4 hours, while the action persists for approximately 6-12 hours.
Maltese: Bil-hydrochlorothiazide, id-dijureżi tibda' fi żmien 2 sigħat, u l-ogħla effett ikun wara madwar 4 sigħat, waqt li l-azzjoni ddum madwar 6-12-il siegħa.
English: CoAprovel 300 mg/12.5 mg film-coated tablets irbesartan/hydrochlorothiazide
Maltese: TAL-PRODOTT MEDIĊINALI CoAprovel 300 mg/12.5 mg pilloli irbesartan/hydrochlorothiazide ISEM
English: dyspepsia, dysgeusia
Maltese: TWISSIJA(IET) SPEĊJALI
English: Peach, biconvex, oval-shaped, with a heart debossed on one side and the number 2876 engraved on the other side.
Maltese: Lewn il-ħawħa, ibbuzzata fuq iż-żewġ naħat, ovali, b'qalb ibbuzzata fuq naħa waħda u numru 2876 mnaqqax fuq in-naħa l-oħra.
English: Uncommon: may affect up to 1 in 100 people
Maltese: Mhux komuni: jistgħu jaffettwaw sa persuna waħda minn kull 100
English: CoAprovel is not indicated in patients with severe hepatic impairment.
Maltese: CoAprovel mhux indikat f'pazjenti b'indeboliment epatiku sever.
English: These lesions were not observed in macaques; decreases in serum potassium due to hydrochlorothiazide and partly prevented when hydrochlorothiazide was given in combination with irbesartan.
Maltese: Dawn il-leżjonijiet ma ġewx osservati fil-makakki; tnaqqis tal-potassium fis-serum minħabba hydrochlorothiazide u mfixkla parzjalment meta hydrochlorothiazide ingħata flimkien ma' irbesartan.
English: Cartons of 84 film-coated tablets in PVC/PVDC/Aluminium blisters.
Maltese: Pakketti ta' 84 pillola miksija b'rita f'folji tal-PVC/PVDC/Aluminju.
English: It is expected to block all actions of angiotensin-II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin-II.
Maltese: Huwa mistenni li jimblokka l-azzjonijiet kollha ta' l-angiotensin-II medjati mir-riċettur AT1, mingħajr m'għandu x'jaqsam ma' l-oriġini jew rotta ta' sinteżi ta' l-angiotensin-II.
English: Furthermore, renal clearance of lithium is reduced by thiazides so the risk of lithium toxicity could be increased with CoAprovel.
Maltese: U wkoll, tneħħija renali ta' lithium titnaqqas b'thiazides u għalhekk, ir-riskju ta' tossiċita' minn lithium tista' tiżdied b'CoAprovel.