FrancophonIA/ELRC3.0 huggingface dataset:
English: In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility.
Maltese: B'mod partikolari, sildenafil għandu selettività ta' 4,000 darba għall-PDE5 fuq il-PDE3, liżoforma cAMP-speċifika tal-fosfodiesterażi involuta fil-kontroll tal-kontrattilità kardijaka.
English: Sildenafil Actavis 50 mg tablets Each tablet contains 124.76 mg lactose (as monohydrate).
Maltese: Kull pillola fiha 124.76 mg lactose (bħala monohydrate).
English: After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%).
Maltese: Wara doża orali waħda ta' 100 mg, l-ogħla konċentrazzjoni medja totali ta' plażma ta' sildenafil hija bejn wieħed u ieħor 440 ng/mL (CV 40%).
English: Sildenafil Actavis 100 mg tablets Each tablet contains 249.52 mg lactose (as monohydrate).
Maltese: Kull pillola fiha 249.52 mg lactose (bħala monohydrate).
English: Co-administration of sildenafil with ritonavir is not advised (see section 4.5).
Maltese: Il-ko-amministrazzjoni ta' sildenafil ma' ritonavir mhix rakkomandata (ara sezzjoni 4.5).
English: Haematuria
Maltese: Hafnarfjörður
English: Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM).
Maltese: Minħabba li sildenafil (u l-metabolit fiċċirkolazzjoni ewlenieni tiegħu N-desmethyl) huwa 96% marbut ma' protejini tal-plażma, dan jirriżulta fl-ogħla konċentrazzjoni ta' plażma ħielsa għal sildenafil ta' 18 ng/mL (38 nM).
English: Co-administration of the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg twice daily) with sildenafil (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil Cmax and a 1,000% (11-fold) increase in sildenafil plasma AUC.
Maltese: Ko-amministrazzjoni tal-inibitur ta' HIV protease ritonavir, li huwa inibitur potenti ħafna tal-P450, fi stat stabbli (500 mg darbtejn kuljum) ma' sildenafil (100 mg doża waħda) irriżultat f'żieda ta' 300% (4 darbiet) fis-Cmax ta' sildenafil u żieda ta' 1000% (11-il darba) fl-AUC tal-plażma ta' sildenafil.
English: Paediatric population Sildenafil Actavis is not indicated for individuals below 18 years of age.
Maltese: Popolazzjoni pedjatrika Sildenafil Actavis mhix indikata għal individwi taħt l-età ta' 18 sena.
English: Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route).
Maltese: Il-metaboliżmu ta' sildenafil iseħħ l-aktar permezz tal-iżoformi taċ-ċitokromju P450 (CYP) 3A4 (rotta ewlenija ) u 2C9 (rotta minuri).
English: · Risk Management Plan (RMP) Not applicable.
Maltese: Pjan tal-ġestjoni tar-riskju (RMP) Mhux applikabbli.
English: The mean steady state volume of distribution (Vd) for sildenafil is 105 l, indicating distribution into the tissues.
Maltese: Il-medja tal-volum ta' distribuzzjoni fi stat fiss (Vd) għal sildenafil huwa 105 l, li jindika distribuzzjoni fit-tessut.
English: Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.
Maltese: Dożi orali singli ta' sildenafil sa 100 mg f'voluntiera b'saħħithom ma għamlu l-ebda effett klinikalment relevanti fuq l-ECG.
English: In addition, N-desmethyl metabolite AUC and Cmax values were significantly increased 79% and 200% respectively.
Maltese: Barra minn hekk, il-valuri AUC u Cmax tal-metabolit N-desmethyl żdiedu sinfikativament b'79% u 200% rispettivament.
English: The Sildenafil Actavis tablet contains lactose monohydrate.
Maltese: LISTA TA' SUSTANZI MHUX ATTIVI Fih il-lactose monohydrate.
English: Epistaxis, Sinus congestion
Maltese: Epistassi (tinfaġar), Konġestjoni tassinus
English: EU/1/09/595/001 [1 film-coated tablet] EU/1/09/595/002 [2 film-coated tablets] EU/1/09/595/003 [4 film-coated tablets] EU/1/09/595/004 [8 film-coated tablets] EU/1/09/595/005 [12 film-coated tablets] EU/1/09/595/016 [24 film-coated tablets]
Maltese: EU/1/09/595/001 [1 pilloli miksija b'rita] EU/1/09/595/002 [2 pilloli miksija b'rita] EU/1/09/595/003 [4 pilloli miksija b'rita] EU/1/09/595/004 [8 pilloli miksija b'rita] EU/1/09/595/005 [12 pilloli miksija b'rita] EU/1/09/595/016 [24 pilloli miksija b'rita]
English: The recommended starting dose is 50 mg.
Maltese: Id-doża rrakkomandata hija 50 mg.
English: In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n=9), sildenafil (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress).
Maltese: Fi studju żgħir kontrollat bilplaċebo ta' pazjenti b'deġenerazzjoni makulari bikrija dokumentata relatata mal-età (n=9), sildenafil (doża waħda, 100 mg) ma wera ebda tibdil sinifikanti f'testijiet tal-vista li saru ( kemm tkun akuta lvista, Amsler grid, diskriminazzjoni ta' kulur ta' dwal tat-traffiku simulati, Humphrey perimeter u photostress).
English: PDE5 inhibitors, such as Sildenafil Actavis have been shown to increase the hypotensive effects of this medicine.
Maltese: Inibituri PDE5, bħal Sildenafil Actavis ġew murija li jżidu l-effetti ipotensivi ta' din ilmediċina.
English: Sildenafil Actvis 25 mg, 50 mg and 100 mg film-coated tablets Sildenafil Actavis 25 mg film-coated tablets Sildenafil Actavis 50 mg film-coated tablets Sildenafil Actavis 100 mg film-coated tablets sildenafil
Maltese: Sildenafil Actavis pilloli miksija b'rita tal-25mg, 50mg u 100mg Sildenafil Actavis 25 mg pilloli miksija b'rita Sildenafil Actavis 50 mg pilloli miksija b'rita Sildenafil Actavis 100 mg pilloli miksija b'rita sildenafil
English: Pooling of the following classes of antihypertensive medication: diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products (vasodilator and centrally-acting), adrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment.
Maltese: Ġbir ta' dawn il-każi li ġejjin ta' medikazzjoni ta' kontra l-pressjoni għolja: dijuretiċi, beta-blokers, inibituri ta' ACE, antagonisti ta' anġotensina II, prodotti mediċinali kontra l-pressjoni għolja (vażodilataturi u li jaħdmu fuq is-sistema ċentrali), adrenergic neurone blockers, channel blockers talkalċju u alpha-adrenoceptor blockers, ma wrew ebda differenza fil-profil ta' effetti f'pazjenti li ħadu sildenafil mqabblin ma' kura bil-plaċebo.
English: In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62% (25 mg), 74% (50 mg) and 82% (100 mg) compared to 25% on placebo.
Maltese: Fi studji ta' doża fissa, il-proporzjon ta' pazjenti li rrappurtaw li l-kura tejbet l-erezzjonijiet tagħhom kienu 62% (25 mg), 74% (50 mg), u 82% (100 mg) mqabbla ma' 25% fuq il-plaċebo.
English: EU/1/09/595/006 [1 film-coated tablet] EU/1/09/595/007 [2 film-coated tablets] EU/1/09/595/008 [4 film-coated tablets] EU/1/09/595/009 [8 film-coated tablets] EU/1/09/595/010 [12 film-coated tablets] EU/1/09/595/017 [24 film-coated tablets]
Maltese: EU/1/09/595/006 [1 pilloli miksija b'rita] EU/1/09/595/007 [2 pilloli miksija b'rita] EU/1/09/595/008 [4 pilloli miksija b'rita] EU/1/09/595/009 [8 pilloli miksija b'rita] EU/1/09/595/010 [12 pilloli miksija b'rita] EU/1/09/595/017 [24 pilloli miksija b'rita]
English: Co-administration of the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state (1200 mg three times a day) with sildenafil (100 mg single dose) resulted in a 140% increase in sildenafil Cmax and a 210% increase in sildenafil AUC.
Maltese: Ko-amministrazzjoni tal-inibitur ta' HIV protease saquinavir, inibitur ta' CYP3A4, fi stat stabbli (1200 mg tlett darbiet kuljum) ma' sildenafil (100 mg doża waħda) irriżultat f'żieda ta' 140% fis-Cmax ta' sildenafil u żieda ta' 210% fl-AUC ta' sildenafil.
English: This is consistent with ritonavir's marked effects on a broad range of P450 substrates.
Maltese: Dan huwa konsistenti maleffetti sinifikanti ta' ritonavir fuq varjeta wiesgħa ta' sustrati ta' P450.
English: The mean maximum decreases in supine systolic blood pressure following 100 mg oral dosing of sildenafil was 8.4 mmHg.
Maltese: L-ogħla tnaqqis medju fil-pressjoni sistolika f'pożizzjoni minduda wara 100 mg ta' sildenafil doża orali kien ta' 8.4 mmHg.
English: INFORMATION IN BRAILLE Sildenafil Actavis 25 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Sildenafil Actavis 25 mg
English: Table 1: Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance
Maltese: Tabella 1: Reazzjonijiet avversi ta' importanza medika b'inċidenza ta' rapporti akbar minn plaċebo fi studji kliniċi kkontrollati, u reazzjonijiet avversi ta' importanza medika rrappurtati minn sorveljanza ta'wara t-tqegħid tal-prodott fis-suq.
English: After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range (25-100 mg).
Maltese: Wara doża orali ta' sildenafil l-AUC u Cmax jiżdiedu fi proporzjon mad-doża fuq il-medda rakkomandata tad-doża (25 -100 mg).
English: Τηλ: +357 22583333
Maltese: Potamitis Medicare Ltd Τηλ: +357 22583333
English: Sildenafil Actavis 25 mg tablets Each tablet contains 62.38 mg lactose (as monohydrate).
Maltese: Kull pillola fiha 62.38 mg lactose (bħala monohydrate).
English: How to store Sildenafil Actavis
Maltese: Tiħux Sildenafil Actavis
English: Respiratory, thoracic and mediastinal disorders
Maltese: Disturbi respiratorju, toraċiċi u medjastinali
English: Each tablet contains 25 mg, 50 mg or 100 mg of sildenafil (as citrate).
Maltese: Kull pillola fiha 25 mg, 50mg jew 100mg ta' sildenafil (bħala ċitrat).
English: INFORMATION IN BRAILLE Sildenafil Actavis 100 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Sildenafil Actavis 100 mg
English: croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide (E171),
Maltese: - L-ingredjenti l-oħra huma: lactose monohydrate, microcrystalline cellulose, povidone K29-32, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide (E171), macrogol 6000, indigo carmine aluminium lake (E132).
English: Uncommon (may affect up to 1 in 100 people): vomiting, skin rash, eye irritation, bloodshot eyes /red eyes, eye pain, seeing flashes of light, visual brightness, light sensitivity, watery eyes, pounding heartbeat, rapid heartbeat, high blood pressure, low blood pressure, muscle pain, feeling sleepy, reduced sense of touch, vertigo, ringing in the ears, dry mouth, blocked or stuffy sinuses, inflammation of the lining of the nose (symptoms include runny nose, sneezing and stuffy nose), upper abdominal pain, gastro-oesophageal reflux disease (symptoms include heartburn), presence of blood in urine, pain in the arms or legs, nosebleed, feeling hot and feeling tired.
Maltese: Mhux komuni (jistgħu jaffettwaw sa persuna minn kull 100): rimettar, raxx, irritazzjoni flgħajnejn/għajnejn ħomor, uġigħ fl-għajn, tara leħħiet ta' dawl bħal berqa, luminożità viżwali, sensittività għad-dawl, għajnejn idemmgħu, taħbit qawwi tal-qalb, taħbit tal-qalb mgħaġġel, pressjoni għolja, pressjoni baxxa, uġigħ fil-muskoli, tħossok bin-ngħas, tnaqqis fis-sens tal-mess, vertigo, tisfir fil-widnejn, ħalq xott, imnifsejn imblukkati jew mimlijin, infjammazzjoni tar-rita tal-imnieħer (sintomi jinkludu tnixxija, għatis u imnieħer miżdud), uġigħ addominali fil-parti ta' fuq, mard tar-rifluss gastroesofaġeali (sintomi jinkludu ħruq ta' stonku), demm fl-awrina, uġigħ fid-dirgħajn u r-riġlejn, fsada fl-imnieħer, sensazzjoni ta' sħana u għejja.
English: In a penile plethysmography (RigiScan) study of fasted patients, the median time to onset for those who obtained erections of 60% rigidity (sufficient for sexual intercourse) was 25 minutes (range 12-37 minutes) on sildenafil.
Maltese: Fi studju tal-pene bil-plestismografu (RigiScan) f'pazjenti sajmin, il-ħin medjan biex jibdew l-erezzjonijiet għal dawk li kisbu 60% riġidità (suffiċjenti għal rapport sesswali) kien 25 minuta (medda bejn 12-37 minuta) b'sildenafil.
English: In a study of the hemodynamic effects of a single oral 100 mg dose of sildenafil in 14 patients with severe coronary artery disease (CAD) (>70% stenosis of at least one coronary artery), the mean resting systolic and diastolic blood pressures decreased by 7% and 6% respectively compared to baseline.
Maltese: Fi studju tal-effetti imodinamiċi ta' doża waħda orali ta' 100 mg sildenafil f'14-il pazjenti b'mard sever tal-arterji tal-qalb (CAD) (>70% stenożi f'ta mill-anqas arterja waħda tal-qalb), il-pressjoni medja tad-demm sistolika u dijastolika waqt l-mistrieħ naqsu b'7% u 6% rispettivament mqabbla mallinja bażi.
English: Lacrimation disorders***, Eye pain, Photophobia, Photopsia, Ocular hyperaemia, Visual brightness, Conjunctivitis
Maltese: Disturbi fil-ħruġ tad-dmugħ***, Uġigħ fl-għajnejn, Fotofobija, Fotopsija, Iperemija okulari, Luminożità viżwali,
English: The dosing recommendations described in ‘Use in adults' apply to patients with mild to moderate renal impairment (creatinine clearance=30-80 mL/min).
Maltese: Ir-rakkomandazzjonijiet ta' dożaġġi mfissra f' “Użu fl-adulti” japplikaw għal pazjenti b'indeboliment ħafif għal moderat tal-kliewi (tneħħija tal-krejatinina=30-80 mL/min).
English: INFORMATION IN BRAILLE Sildenafil Actavis 50 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Sildenafil Actavis 50 mg
English: Sildenafil Actavis should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Maltese: Sildenafil Actavis m'għandux jingħata lillirġiel li għandhom problemi ereditarji ta' intolleranza għall-galattożju, defiċjenza fil-lattażju Lapp jew li għandhom problemi fl-assorbiment tal-glukożju-galattożju.
English: The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension (see section
Maltese: It-teħid flimkien ta' inibituri ta' PDE5, inkluż sildenafil, ma' stimulaturi ta' guanylate cyclase, bħal riociguat, huwa kontraindikat billi dan jista' potenzjalment iwassal għal ipotensjoni sintomatika (ara sezzjoni 4.5).
English: Due to the nitrate component it has the potential to result in a serious interaction with sildenafil.
Maltese: Minħabba il-komponent ta' nitrate, hemm il-potenzjal li jirriżulta f' interazzjoni serja ma' sildenafil.
English: In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, (an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19) at steady state (125 mg twice a day) with sildenafil at steady state (80 mg three times a day) resulted in 62.6% and 55.4% decrease in sildenafil AUC and Cmax, respectively.
Maltese: [moderat], CYP2C9 u possibbilment ta' CYP2C19) fi stat stabbli (125 mg darbtejn kuljum) ma' sildenafil fi stat stabbli (80 mg tliet darbiet kuljum) irriżulta 62.6% u 55.4% tnaqqis fl-AUC u Cmax ta' sildenafil rispettivament.
English: Sildenafil Actavis potentiates the hypotensive effect of nitrates (see section 4.3).
Maltese: Sildenafil Actavis issaħħaħ l-effett ipotensiv tan-nitrati (ara sezzjoni 4.3).
English: This drug is used to treat pulmonary arterial hypertension (i.e., high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e., high blood pressure in the lungs secondary to blood clots).
Maltese: Din il-mediċina hija użata biex tikkura pressjoni għolja arterjali pulmonari (i.e., pressjoni għolja tad-demm fil-pulmuni) u pressjoni għolja pulmonari tromboemboliku kroniku (i.e., pressjoni għolja tad-demm fil-pulmuni kkawżata minn ċapep fiddemm).
English: Nausea, Dyspepsia
Maltese: Ngħas tqil, Ipostesja
English: Visual colour distortions**, Visual disturbance, Vision blurred
Maltese: Diffikultà li tagħraf ilkuluri**, Disturbi fil-vista, Vista mċajpra
English: Myocardial infarction, Ventricular arrhythmia, Atrial fibrillation, Unstable angina
Maltese: Mewta kardijaka għall-għarrieda, Infart mijokardijaku, Arritmija ventrikulari, Fibrillazzjoni atrijali, Anġina instabbli
English: Sildenafil Actavis 100 mg film-coated tablets
Maltese: Sildenafil Actavis 100 mg tablets
English: Myopia,
Maltese: Emorraġija filpene,
English: The major circulating metabolite results from N-demethylation of sildenafil.
Maltese: Il-metabolit ċirkulatorju ewlieni jirriżulta minn N-demethylation ta' sildenafil.
English: Consistent with its known effects on the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway (see section 5.1), sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitric oxide donors (such as amyl nitrite) or nitrates in any form is therefore contraindicated.
Maltese: Konsistenti mal-effetti magħrufa tiegħu fuq ir-rotta ossidu nitriku (nitric oxide) / monofosfat talgwanosina ċikliku (cyclic guanosine monophosphate (cGMP) ) (ara sezzjoni 5.1), sildenafil intwera li jsaħħaħ l-effetti ipotensivi tan-nitrati, u l-ko-amministrazzjoni tiegħu ma' donaturi ta' ossidu nitriku (bħan-nitrit tal-amil (amyl nitrite) jew nitrati f'xi forma oħra hija għalhekk kontra-indikata.
English: Consistent with its known effects on the nitric oxide/cGMP pathway (see section 5.1), sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitric oxide donors or nitrates in any form is therefore contraindicated (see section 4.3).
Maltese: B'mod konformi mal-effetti magħrufin ta' sildenafil fuq ir-rotta tal-ossidu nitriku/cGMP (ara sezzjoni 5.1), intwera li sildenafil iżid l-effett tan-nitrati li jnaqqsu l-pressjoni, u għaldaqstant il-koamministrazzjoni ta' sildenafil u donaturi tal-ossidu nitriku jew nitrati hija kontraindikata (ara sezzjoni 4.3).
English: Single doses of antacid (magnesium hydroxide/aluminium hydroxide) did not affect the bioavailability of sildenafil.
Maltese: Doża waħda ta' mediċina kontra l-aċidu fl-istonku (idrossidu tal-manjeżju/ idrossidu tal-aluminju) ma effettwatx il-biodisponiblità ta' sildenafil.
English: Sildenafil Actavis 100 mg film-coated tablets PVC-PVDC/Aluminium blisters in cartons of 1, 2, 4, 8, 12 or 24 tablets.
Maltese: Folji tal-PVC-PVDC/Aluminium f‘kartuniet ta‘ 1, 2, 4, 8, 12 jew 24 pillola.
English: Package leaflet: Information for the patient
Maltese: Sorsi oħra ta‘ informazzjoni
English: When a single 100 mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg twice daily for 5 days), there was a 182% increase in sildenafil systemic exposure (AUC).
Maltese: Meta doża waħda ta' 100 mg sildenafil ġiet amministrata ma' erythromycin, inibitur ta' CYP3A4moderat, fi stat stabbli (500 mg darbtejn kuljum għal 5 jiem), kien hemm żieda ta' 182% flespożizzjoni sistemika (AUC) ta' sildenafil.
English: In volunteers with mild to moderate hepatic cirrhosis (Child-Pugh A and B) sildenafil clearance was reduced, resulting in increases in AUC (84%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment.
Maltese: F'voluntiera b'ċirrożi ħafifa għal moderata tal-fwied ( Child-Pugh A u B), it-tneħħija ta' sildenafil tnaqqas, u rriżulta f'żidiet fl-AUC (84%) u Cmax (47%) mqabbel ma' voluntiera tal-istess età li ma kellhomx ħsara fil-fwied.
English: Sildenafil Actavis 100 mg film-coated tablets are blue elliptical, biconvex, 17.0 x 8.5 mm and marked “SL100” on one side.
Maltese: Il-pilloli miksija b'rita Sildenafil Actavis 100 mg huma blu, ellittiċi, bikonvessi, 17.0 x 8.5 mm u mmarkati "SL100" fuq naħa minnhom.
English: Film-coat:
Maltese: Riociguat:
English: 4.6 Fertility, pregnancy and lactation
Maltese: .6 Fertilita', tqala u treddigħ
English: Sildenafil Actavis 50 mg film-coated tablets PVC-PVDC/Aluminium blisters in cartons of 1, 2, 4, 8, 12 or 24 tablets.
Maltese: Folji tal-PVC-PVDC/Aluminium f'kartuniet ta'1, 2, 4, 8, 12 jew 24 pillola.
English: Sildenafil Actavis 25 mg film-coated tablets
Maltese: Sildenafil Actavis 25 mg pilloli
English: In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC, Cmax, tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite.
Maltese: F' rġiel voluntiera normali u b'saħħithom, ma kienx hemm evidenza ta' xi effett ta' azithromycin (500 mg kuljum għal 3 jiem) fuq ir-rata tal-eliminazzjoni fissa tal-AUC, Cmax u Tmax, jew il-half life ta' wara ta' sildenafil jew tal-metabolit prinċipali tiegħu fiċċirkolazzjoni.
English: A. Potamitis Medicare Ltd
Maltese: 4.1 Indikazzjonijiet terapewtiċi
English: PUREN Pharma GmbH & Co. KG Tel: +49 895589090
Maltese: KG Tel: +49 895589090
English: Each tablet contains sildenafil citrate equivalent to 25 mg of sildenafil
Maltese: Kull pillola fiha sildenafil citrate ekwivalenti għal 25 mg ta' sildenafil
English: Sildenafil Actavis 50 mg film-coated tablets are blue elliptical, biconvex, 13.0 x 6.5 mm and marked “SL50” on one side.
Maltese: Il-pilloli miksija b'rita Sildenafil Actavis 50 mg huma blu, ellittiċi, bikonvessi, 13.0 x 6.5 mm u mmarkati "SL50" fuq naħa minnhom.
English: In healthy male volunteers, sildenafil at steady state (80 mg t.i.d.)
Maltese: F'voluntiera rġiel b'saħħithom, sildenafil fi stat stabbli (80 mg t.i.d.) irriżulta f'żieda ta' 49.
English: EU/1/09/595/011 [1 film-coated tablet] EU/1/09/595/012 [2 film-coated tablets] EU/1/09/595/013 [4 film-coated tablets] EU/1/09/595/014 [8 film-coated tablets] EU/1/09/595/015 [12 film-coated tablets] EU/1/09/595/018 [24 film-coated tablets]
Maltese: EU/1/09/595/011 [1 pilloli miksija b'rita] EU/1/09/595/0012 [2 pilloli miksija b'rita] EU/1/09/595/013 [4 pilloli miksija b'rita] EU/1/09/595/014
English: Toxic Epidermal
Maltese: GĦAMLA FARMAĊEWTIKA
English: Sildenafil Actavis 25 mg film-coated tablets are blue elliptical, biconvex, 10.0 x 5.0 mm and marked “SL25” on one side.
Maltese: Il-pilloli miksija b'rita Sildenafil Actavis 25 mg huma blu, eliitiċi, bikonvessi, 10.0 x 5.0 mm u mmarkati "SL25" fuq naħa minnhom.
English: These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle.
Maltese: Dan it-tnaqqis fil-pressjoni tad-demm huwa konsistenti maleffetti ta' vażodilatazzjoni ta' sildenafil, probabilment minħabba żieda fil-livelli ta' cGMP fil-muskoli lixxi vaskulari.
English: Asthenopia, Vitreous floaters, Iris disorder, Mydriasis, Halo vision, Eye oedema, Eye swelling, Eye disorder, Conjunctival hyperaemia, Eye irritation, Abnormal sensation in eye, Eyelid oedema, Scleral
Maltese: Retinopatija arterjosklerotika, Disturbi retinal, Glawkoma, Difett fil-kamp viżiv, Diplopja, Preċiżjoni viżiva mnaqqsa, Mijopija, Astenopja, Frak f'wiċċ il-likwidu vitruż,
English: The total body clearance of sildenafil is 41 L/h with a resultant terminal phase half-life of 3-5 h. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the faeces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of administered oral dose).
Maltese: Wara jew amministrazzjoni orali jew fil-vina, sildenafil jitneħħa bħala metaboli b'mod predominanti fl-ippurgar (bejn wieħed u ieħor 80% tad-doża orali amministrata) u f'proporzjon anqas fl-urina (bejn wieħed u ieħor 13% tad-doża orali amministrata).