FrancophonIA/ELRC3.0 huggingface dataset:
English: Post-hoc analysis over 6 and 12 weeks in the same study, as well as 6-week HPA axis safety study, supported the efficacy of fluticasone furoate nasal spray 110 micrograms once daily.
Danish: Effekten af fluticasonfuroat næsespray 110 mikrogram 1 gang daglig blev bekræftet i en post hoc-analyse over 6 og 12 uger i det samme kliniske studie samt i et 6 ugers HPA-aksesikkerhedsstudie.
English: • Check you still have medicine left.
Danish: • Se efter at flasken ikke er tom.
English: Contents of the pack and other information Step-by-step guide to using the nasal spray
Danish: Pakningsstørrelser og yderligere oplysninger Brugervejledning
English: If you have any further questions on the use of this medicine, or if you have any discomfort using the nasal spray ask your doctor or pharmacist or nurse.
Danish: Spørg lægen eller apotekspersonalet, hvis der er noget, du er i tvivl om, eller hvis det er ubehageligt at bruge næsesprayen.
English: • The usual starting dose is 2 sprays in each nostril once every day.
Danish: Voksne og børn fra 12 år • Den sædvanlige startdosis er 2 pust i hvert næsebor 1 gang daglig.
English: The treatment should continue for a minimum of 3 days.
Danish: Behandlingen skal fortsætte i mindst 3 dage.
English: GROUNDS FOR RECOMMENDATION OF THE GRANTING OF A MARKETING AUTHORISATION
Danish: BEGRUNDELSE FOR ANBEFALING AF UDSTEDELSE AF MARKEDSFØRINGSTILLADELSE
English: Chickens and turkeys
Danish: Kyllinger og kalkuner
English: OVERALL SUMMARY OF THE SCIENTIFIC CONCLUSIONS 1.
Danish: SAMLET RESUMÉ AF DE FAGLIGE KONKLUSIONER 1.
English: All validity criteria of the guideline were fulfilled.
Danish: Alle retningslinjens validitetskriterier var opfyldt.
English: It is not clear to what extent a population recovery may have occurred at the end of the test period.
Danish: Det fremgår ikke klart, i hvilket omfang der kan være forekommet en populationsgenfinding ved afslutningen af testperioden.
English: For the treatment of salmonellosis treatment should be extended to 5 days.
Danish: Til behandling af salmonellose bør behandlingen forlænges til 5 dage.
English: 11-12 Pol. Ind. La Borda 08140 Caldes de Montbui SPAIN
Danish: 11-12 Pol. Ind. La Borda 08140 Caldes de Montbui SPANIEN
English: The number and variation in the soil types are considered acceptable.
Danish: Antallet og variationen i jordtyperne betragtes som acceptable.
English: With the existing disappearance data it would be necessary to use a time-weighted-average approach.
Danish: Med de eksisterende nedbrydningsdata ville det være nødvendigt at anvende en tidsvægtet gennemsnitsmetode.
English: The study was not considered further as it contained insufficient detail.
Danish: Undersøgelsen blev ikke taget i betragtning, fordi den ikke var tilstrækkeligt detaljeret.
English: The difference in DT50 and DT90 values are relative small.
Danish: Forskellen i DT50- og DT90-værdier er relativt lille.
English: Only two data points are available, i.e. the start and end of the study, where unfortunately no precise level of concentration recovery was reported (less than 20%).
Danish: Der er kun to tilgængelige datapunkter, dvs. undersøgelsens start og afslutning, hvor der desværre ikke er rapporteret nogen nøjagtig koncentrationsgenfinding (mindre end 20 %).
English: The calculations for the minor species turkeys were not considered further in this referral as the risk in any case will be lower.
Danish: Beregningerne for de mindre arter af kalkuner blev ikke yderligere overvejet i denne indbragte sag, da risikoen under alle omstændigheder vil være lavere.
English: In particular the adequacy of the data provided in respect to the environmental risk assessment regarding these two points was questioned.
Danish: Der blev i særdeleshed sat spørgsmålstegn ved, om de fremlagte data var tilstrækkelige med hensyn til miljørisikovurderingen på disse to områder.
English: This is a major reason why the EU (EMEA/CVMP) has made the testing of cyanobacteria mandatory for all antibiotics.
Danish: Det er en væsentlig årsag til, at EU (EMEA/CVMP) har gjort det obligatorisk at teste cyanobakterier for alle antibiotika.
English: A study, taken from the open literature, Boxall et al (2006)3, was also provided.
Danish: Der blev også fremlagt en undersøgelse fra den åbne litteratur, Boxall et al (2006)3.
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE VETERINARY MEDICINAL PRODUCT, ANIMAL SPECIES, ROUTE OF ADMINISTRATION, APPLICANT IN THE MEMBER STATES
Danish: BILAG I LISTE OVER LÆGEMIDLETS NAVNE, LÆGEMIDDELFORM OG STYRKE FOR DET VETERINÆRMEDICINSKE PRODUKT, DYREARTER, INDGIVELSESVEJ, ANSØGER I MEDLEMSSTATERNE
English: Assessment of the environmental risk
Danish: Vurdering af miljørisikoen
English: 2.3.4 Microorganisms
Danish: 2.3.4 Mikroorganismer
English: The correlation between measured parameters and dry weight of biomass should have been reported.
Danish: Forholdet mellem målte parametre og biomassens tørstofvægt skulle have været rapporteret.
English: A study taken from the open literature, Knapp et al (2005)4, indicated that exposure is very low.
Danish: En undersøgelse fra den åbne litteratur, Knapp et al (2005)4, tydede på, at eksponeringen er meget lav.
English: The soil characteristics and resulting DT50 and DT90 values were: DT50: 141, 103, 99 and 149 days; DT90: 469, 342, 330 and 495 days.
Danish: Jordens karakteristika og de følgende DT50- og DT90-værdier var: DT50: 141, 103, 99 og 149 dage; DT90: 469, 342, 330 og 495 dage.
English: The growth rates are unlikely to have been exponential, and therefore the tests are likely to have been conducted under sub-optimal sensitivity.
Danish: Det er usandsynligt, at vækstraterne har været eksponentielle, og derfor er det sandsynligt, at testen er blevet udført med en sensitivitet, som ikke er optimal.
English: The Committee recognised that the design of the study had deficiencies but agreed that the results can be used for the PEC calculations.
Danish: Udvalget anerkendte, at der var mangler ved undersøgelsens form, men var enigt om, at resultaterne kan anvendes til PEC-beregninger.
English: The EC50 values for M. aeruginosa and P. subcapitata were 49 and 3,100 µg/l, respectively.
Danish: EC50-værdierne for M. aeruginosa og P. subcapitata var henholdsvis 49 og 3.100 µg/l.
English: If one assumes a worst case situation, then the highest DT50 should be used for further assessment (e.g. PECSoil-plateau calculations).
Danish: Hvis man antager en worst-case-situation, bør den højeste DT50 anvendes til yderligere bedømmelse (f.eks. PECjord-plateau-beregninger).
English: The geometric mean concentration during exposure was used to estimate a more realistic effect-measure compared to the nominal concentrations as also suggested in OECD 201.
Danish: Den geometriske gennemsnitskoncentration under eksponering blev anvendt til at estimere et mere realistisk effektmål sammenlignet med de nominelle koncentrationer, som også er foreslået i OECD 201.
English: Other data are taken from peer reviewed articles published in the open literature.
Danish: Andre data stammer fra peer review-bedømte artikler offentliggjort i den åbne litteratur.
English: The Koc was calculated as 110,885 l kg/1(geometric mean).
Danish: Koc blev beregnet til 110.885 l kg/1(geometrisk gennemsnit).
English: If a less conservative approach is taken, the geometric mean of the four DT50 values could be used, i.e. 121 days.
Danish: Hvis man benytter en mindre konservativ metode, kan det geometriske gennemsnit af de fire DT50-værdier anvendes, dvs. 121 dage.
English: However, the data for the test on cyanobacteria Microcystis aeruginosa does not meet validity criteria required in OECD guideline 201.
Danish: Imidlertid overholder data for testen af cyanobakterien Microcystis aeruginosa ikke de validitetskriterier, som kræves i OECD's retningslinje 201.
English: No further consideration is made to the data of the green algae as this was more than 50 times less sensitive to enrofloxacin.
Danish: Data for grønalger overvejes ikke yderligere, da disse var mere end 50 gange mindre følsomme over for enrofloxacin.
English: Consequently no risk quotient (PEC/PNEC) is derived for cyanobacteria.
Danish: Der udledes derfor ingen risikokvotient (PEC/PNEC) for cyanobakterier.
English: The product is intended to be used for the treatment of diseases of the respiratory and alimentary tracts of bacterial or mycoplasmal origin in chickens and turkeys.
Danish: Produktet er beregnet til behandling af sygdomme i luftvejene og fordøjelseskanalen af bakteriel eller mycoplasmal oprindelse hos kyllinger og kalkuner.
English: 2.3.Effect studies and calculation of PNEC values
Danish: 2.2 Effektundersøgelser og beregninger af PNEC-værdier
English: Antibiotics are likely to be toxic to algae and cyanobacteria.
Danish: Antibiotika er sandsynligvis toksisk for alger og cyanobakterier.
English: Given the uncertainty of the fate and disappearance of enrofloxacin during the course of the test, the CVMP cannot support using the nominal concentrations for the establishment of EC50 values.
Danish: I betragtning af usikkerheden med hensyn til enrofloxacins skæbne og nedbrydning under testforløbet kan CVMP ikke støtte anvendelse af de nominelle koncentrationer til fastlæggelse af EC50-værdier.
English: A conservative PNEC value could hence be established at 10 µg/l.
Danish: Der kunne således fastsættes en konservativ PNEC-værdi på 10 µg/l.
English: The applicant provided an environmental risk assessment for Enro-K 10% Oral Solution that followed in general the established guidelines and recommendations.
Danish: Ansøgeren fremlagde en miljørisikovurdering for Enro-K 10 % Oral Opløsning, som i store træk fulgte de fastlagte retningslinjer og anbefalinger.
English: 2.2 Calculation of PEC values
Danish: 2.2 Beregning af PEC-værdier
English: For all species tested a clear concentration dependent effect occurred and EC50 and NOEC values were found in the range of 124 to 435 and less than 10 to 100 mg/kg, respectively.
Danish: For alle de testede arter opstod en klar koncentrationsafhængig virkning, og der blev fundet EC50- og NOEC-værdier i området henholdsvis 124 til 435 og mindre end 10 til 100 mg/kg.
English: The coefficient of variation (CoV) was not provided, however the relatively narrow span of the 95% confidence interval around the estimated EC50 values qualitatively indicates an acceptable variation in data.
Danish: Variationskoefficienten (CoV) er ikke opgivet, men 95 % konfidensintervallets relativt smalle område omkring de estimerede EC50-værdier indicerer kvalitativt en acceptabel variation i data.
English: 50 ml of product per 100 litres water or 10 mg of the active ingredient per kg bodyweight per day.
Danish: 50 ml af produktet pr. 100 liter vand eller 10 mg af det aktive stof pr. kg legemsvægt pr. dag.
English: A comprehensive set of data needed to conduct an environmental risk assessment according to the VICH and CVMP guidelines was provided.
Danish: Der blev fremlagt et omfattende datasæt, som var nødvendigt for at foretage en miljørisikovurdering ifølge VICH- og CVMP-retningslinjerne.
English: 2.4 Risk characterisation
Danish: 2.4 Risikokarakterisering
English: However, growth (on a fresh weight per plant basis) of all species tested was significantly inhibited by enrofloxacin.
Danish: Væksten for alle de testede arter (på basis af frisk vægt pr. plante) var imidlertid signifikant hæmmet af enrofloxacin.
English: As ciprofloxacin represents only 2% of the total outcome of the enrofloxacin metabolism in chickens it is assumed that any potential risk of metabolites is encompassed by using the total residue approach assuming that the total dose is excreted as parent compound or as metabolites with a toxicity that is similar to the parent compound.
Danish: Da ciprofloxacin kun udgør 2 % af det totale resultat af enrofloxacin-metabolismen hos kyllinger, antages det, at en potentiel risiko for metabolitter dækkes ved at anvende den totale restmetode, under forudsætning af at hele dosis udskilles som det oprindelige stof eller som metabolitter med en toksicitet, som er den samme som det oprindelige stof.
English: The geometric mean of these two EC50 values is 15.9 µg/l.
Danish: Det geometriske gennemsnit af disse to EC50-værdier er 15,9 µg/l.
English: The submitted environmental risk assessment report is based on new studies initiated by the applicant and on bibliographical data extracted from peer reviewed journals.
Danish: Den indsendte miljørisikovurderingsrapport er baseret på nye undersøgelser, som ansøgeren har iværksat, og på bibliografiske data fra peer reviewbedømte tidsskrifter.
English: 2.3.5 Plants
Danish: 2.3.5 Planter
English: The study by Robinson et al 2005 is, overall, a well reported scientific paper, which has been published in a well established international peer reviewed Journal.
Danish: Undersøgelsen af Robinson et al 2005 er generelt en velrapporteret faglig undersøgelse, som er publiceret i et veletableret, internationalt peer review-bedømt tidsskrift.
English: The EC50 for nitrogen transformation was estimated to be above 29 mg/kg soil.
Danish: EC50 for kvælstoftransformation blev estimeret til over 29 mg/kg jord.
English: The seeds were placed in a natural sandy soil containing the test item at nominal concentrations of 10, 31.6, 100, 316 and 1000 mg enrofloxacin/kg dry soil (cucumber, lettuce, mung bean, oat and wheat) and 3, 12, 48, 192 and 768 mg enrofloxacin/kg dry soil (rye), respectively.
Danish: Frøene blev lagt i naturligt sandet jord med testproduktet i nominelle koncentrationer på henholdsvis 10, 31,6, 100, 316 og 1000 mg enrofloxacin/kg tør jord (agurk, salat, mungbønne, havre og hvede) og 3, 12, 48, 192 og 768 mg enrofloxacin/kg tør jord (rug).
English: From this data it can be concluded that there would be no risk at environmental concentrations 10 times the PECsoil value established above (542.9 µg/kg).
Danish: På basis af disse data kan det konkluderes, at der ikke ville være nogen risiko ved miljøkoncentrationer på 10 gange den ovenfor fastsatte PECjord-værdi (542,9 µg/kg).
English: Risk characterisation is calculated from the risk quotient (RQ), which should be less than 1 in all taxonomic levels to consider that enrofloxacin does not represent a risk to the environment.
Danish: Risikokarakterisering beregnes ud fra risikokvotienten (RQ), som bør være under 1 på alle taksonomiske niveauer for enrofloxacin kan anses for ikke at udgøre nogen miljørisiko.
English: The CVMP therefore concludes that the objections raised by Germany should not prevent the granting of a Marketing Authorisation and that the dossier as submitted in the referral procedure fulfils the necessary requirements with regards to the risk assessment for cyanobacteria (blue-green algae) and terrestrial plants.
Danish: CVMP konkluderer derfor, at de af Tyskland rejste betænkeligheder ikke skulle forhindre udstedelse af markedsføringstilladelse, og at dossieret som fremlagt i proceduren for indbragte sager opfylder de nødvendige krav med hensyn til risikovurdering for cyanobakterier (blågrønalger) og terrestriske planter.
English: During the decentralised procedure concerns were raised that Enro-K 10% Oral Solution may present a potential serious risk to the environment regarding risk to blue-green algae and to terrestrial plants.
Danish: Under den decentraliserede procedure blev der ytret betænkeligheder med hensyn til, om Enro-K 10 % Oral Opløsning kan udgøre en potentielt alvorlig miljørisiko med hensyn til risikoen for blågrønalger og terrestriske planter.
English: Enro-K 10% Oral Solution contains 100 mg enrofloxacin as active ingredient per 1 ml product.
Danish: Enro-K 10 % Oral Opløsning indeholder 100 mg enrofloxacin som aktivt stof pr. 1 ml produkt.
English: 2.3.1 Algae
Danish: 2.3.1 Alger
English: The CVMP agrees that the applicant has met all the requirements for the plant toxicity evaluation, i.e. new toxicity data and the use of the PECsoil-plateau based on new degradation studies.
Danish: CVMP er enige om, at ansøgeren har overholdt alle kravene til evaluering af plantetoksicitet, dvs. nye toksicitetsdata og brug af PECjord-plateau baseret på nye nedbrydningsundersøgelser.
English: The following test species were used: Cucumis sativus (cucumber), Lactuca sativa (lettuce), Phaseolus aureus (mung bean), Avena sativa (oat), Triticum aestivum (wheat) and Secale cereale (rye).
Danish: Der blev anvendt følgende testarter: Cucumis sativus (agurk), Lactuca sativa (salat), Phaseolus aureus (mungbønne), Avena sativa (havre), Triticum aestivum (hvede) og Secale cereale (rug).
English: The CVMP concludes that it is not feasible to estimate an exact PNEC value for cyanobacteria based on the study by Robinson et al 2005.
Danish: CVMP konkluderer, at det ikke er muligt at estimere en nøjagtig PNEC-værdi for cyanobakterier baseret på undersøgelsen fra Robinson et al 2005.
English: The Phase I environmental risk assessment following the VICH guideline results in Predicted Environmental Concentrations (PECs) in soil for Enro-K 10% Oral Solution for broiler chickens (10 mg/kg bw/day, for 5 days) above 100 µg/kg, thus requiring a Phase II assessment.
Danish: Ved fase I-miljørisikovurderingen efter VICH-retningslinjerne fremkommer PECs (Predicted Environmental Contrations) i jord for Enro-K 10 % Oral Opløsning til slagtekyllinger (10 mg/kg legemsvægt/dag i 5 dage) over 100 µg/kg, som dermed krævede en fase II-vurdering.
English: 2.1.1 Metabolism and excretion
Danish: 2.1.1 Metabolisme og udskillelse
English: Overall, the CVMP agreed that enrofloxacin is unlikely to pose any significant risk to ground water.
Danish: Generelt var CVMP enige om, at det er usandsynligt, at enrofloxacin udgør nogen signifikant risiko for grundvand.
English: If the geometric mean of DT50 values from the four soils is used, the PECsoil-plateau is 506 µg/kg.
Danish: Hvis den geometriske middelværdi af DT50-værdierne fra de fire jordtyper anvendes, er PECjord-plateau 506 µg/kg.
English: The resulting PECgw value is 0.057 µg/l, which is below the critical trigger value of 0.1 µg/l.
Danish: Den fremkomne PECgv-værdi er 0,057 µg/l, hvilket er under den kritiske udløsningsværdi på 0,1 µg/l.
English: Using the current guidelines the calculated PECsoil-plateau is 542.9 µg/kg.
Danish: Når de aktuelle retningslinjer benyttes, er den beregnede PECjord-plateau 542,9 µg/kg.
English: The disappearance of non-labelled enrofloxacin was investigated according to OECD guideline 307 in four soils with different content of organic carbon and clay and pH values.
Danish: Ikke-mærket enrofloxacins nedbrydning blev undersøgt i overensstemmelse med OECD's retningslinje 307 i fire jordtyper med forskelligt indhold af organisk kul og ler og med forskellige pHværdier.
English: Ciprofloxacin is the main metabolite of enrofloxacin.
Danish: Ciprofloxacin er enrofloxacins hovedmetabolit.
English: The newly performed study was preferred to assess the effect of enrofloxacin on the emergence and growth of terrestrial plants.
Danish: Den nyligt udførte undersøgelse blev foretrukket til bedømmelse af effekten af enrofloxacin på fremkomst og vækst af terrestriske kimplanter.
English: The effect of enrofloxacin on nitrogen transformation by soil organisms was investigated according to OECD guidelines 216 and EU Test Method C.21.
Danish: Effekten af enrofloxacin på kvælstofomdannelse af jordorganismer blev undersøgt ifølge OECDretningslinje 216 og EU-testmetode C.21.
English: Application of the CVMP guideline Environmental Impact Assessment for Veterinary Medicinal Products in support of the VICH guidelines GL6 and GL38 results in an estimate of PECsurfacewater of 0.019 µg/l.
Danish: Ved anvendelse af CVMP's retningslinje for miljøkonsekvensvurdering af veterinærmedicinske lægemidler (Guideline on Environmental Impact Assessment for Veterinary Medicinal Products) i kombination med VICH-retningslinjen GL6 og GL38) fremkommer et estimat for PECoverfladevand på 0,019 µg/l.
English: Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinoline group of antibiotics.
Danish: Enrofloxacin er et syntetisk, bredspektret antimikrobielt stof, som tilhører fluoroquinolon-gruppen af antibiotika.
English: Rye was the most sensitive species, with an EC50 of 124 mg/kg.
Danish: Rug var den mest påvirkelige art med en EC50 på 124 mg/kg.
English: The proposed EC50 values are acceptable and can be used to derive a PNEC value of 1.24 mg/kg (1240 µg/kg).
Danish: De foreslåede EC50værdier er acceptable og kan anvendes til at aflede en PNEC-værdi på 1,24 mg/kg (1240 µg/kg).
English: 2.2.2 PECgroundwater (PECgw)
Danish: 2.2.2 PECgrundvand (PECgv)
English: The application of an assessment factor of 100 leads to a PNEC value of 0.49 µg/l for algae.
Danish: Ved en vurderingsfaktor på 100 fremkommer en PNEC-værdi på 0,49 µg/l for alger.
English: The proposed NOEC values are acceptable and can be used to derive a PNEC value of 100 mg/kg (100,000 µg/kg).
Danish: De foreslåede NOECværdier er acceptable og kan anvendes til at aflede en PNEC-værdi på 100 mg/kg (100.000 µg/kg).
English: A terrestrial plant growth test according to OECD guideline 208 was provided.
Danish: Der blev fremlagt en test af terrestrisk plantevækst ifølge OECD-retningslinje 208.
English: The CVMP concludes from the new studies provided that the applicant has met the requirements for the plant toxicity evaluation.
Danish: CVMP konkluderer på basis af de nye fremlagte undersøgelser, at ansøgeren har overholdt alle kravene til evaluering af plantetoksicitet.
English: Environmental fate studies
Danish: Undersøgelser af miljømæssig skæbne
English: The NOEC for the tested loamy sand field soil was found to be 2.9 mg enrofloxacin per kg soil (dry mass).
Danish: NOEC-værdien for den testede fede sandjord blev målt til 2,9 mg enrofloxacin pr. kg jord (tørstof).
English: The EC50 based on the initial exposure concentration can be estimated to be 51.45 µg/l when considering the EC50 of 49 µg/l based on the nominal start concentration (equal to 100% recovery) and an initial average recovery of 105% of the nominal concentration.
Danish: EC50 baseret på den indledende eksponeringskoncentration kan estimeres til 51,45 µg/l, når man går ud fra en EC50 på 49 µg/l baseret på den nominelle startkoncentration (svarende til 100 % genfinding) og en indledende gennemsnitlig genfinding på 105 % af den nominelle koncentration.
English: 2.1.2 Soil adsorption and desorption A study, published in the peer-reviewed and open literature (Nowara et al 1997)1 indicated that enrofloxacin and other fluoroquinolones are strongly adsorbed to soils with high content in clay minerals of montmorillonite and kaolinite, basically through electrostatic interactions between ionized carboxylated groups of fluoroquinolones and exchangeable cations within clay layers.
Danish: En undersøgelse publiceret i peer review-bedømt litteratur (Nowara et al 1997)1, har vist, at enrofloxacin og andre fluoroquinoloner i høj grad adsorberes i jord med et højt indhold af lermineraler af montmorillonit og kaolinit, hvilket grundlæggende sker via elektrostatiske interaktioner mellem ioniserede carboxylerede grupper af fluoroquinoloner og ombyttelige kationer i lerlagene.
English: From this data set, it is concluded that enrofloxacin, used according to the applicant's indications, does not pose a risk to fresh water invertebrates, fish, soil micro-organism, plants and soil invertebrates.
Danish: På baggrund af dette datasæt kan det konkluderes, at enrofloxacin anvendt i overensstemmelse med ansøgerens anvisninger ikke udgør nogen risiko for hvirvelløse ferskvandsdyr, fisk, mikroorganismer i jorden og hvirvelløse jorddyr.
English: It can be concluded that enrofloxacin does not pose a risk to fresh water invertebrates, fish, soil microorganisms and soil invertebrates.
Danish: Det kan konkluderes, at enrofloxacin ikke udgør nogen risiko for hvirvelløse ferskvandsdyr, fisk, mikroorganismer i jorden og hvirvelløse jorddyr.
English: 2.2.1 PECsoil-plateau
Danish: 2.2.1 PECjord-plateau
English: Higher tier modelling has also revealed a negligible risk for ground water contamination.
Danish: ”Higher tier”-modeller har også vist en forsvindende lille risiko for kontaminering af grundvand.