FrancophonIA/ELRC3.0 huggingface dataset:
English: 30 film-coated tablets: EU/1/17/1249/001 60 film-coated tablets: EU/1/17/1249/002 90 film-coated tablets: EU/1/17/1249/003 180 film-coated tablets: EU/1/17/1249/004
Slovenian: 30 filmsko obloženih tablet: EU/1/17/1249/001 60 filmsko obloženih tablet: EU/1/17/1249/002 90 filmsko obloženih tablet: EU/1/17/1249/003 180 filmsko obloženih tablet: EU/1/17/1249/004
English: Alternative or additional contraceptive measures are recommended when oestrogen-based contraceptives are co-administered
Slovenian: Pri sočasni uporabi estrogenskih kontraceptivov in okrepljenega darunavirja je priporočljiva uporaba alternativnih ali dodatnih kontracepcijskih metod.
English: 800 mg darunavir /100 mg ritonavir once daily
Slovenian: 800 mg darunavirja/100 mg ritonavirja enkrat na dan
English: St John's wort is expected to decrease the plasma concentrations of darunavir or its pharmacoenhancers.
Slovenian: Lahko pričakujemo znižanje plazemskih koncentracij darunavirja ali njegovih farmakokinetičnih ojačevalcev.
English: Estazolam
Slovenian: Izpuščaj
English: Outcomes darunavir/ritonavir 800/100 mg once daily + OBR N=294
Slovenian: Izidi darunavir/ritonavir 800/100 mg enkrat na dan + OBR n = 294
English: Darunavir Krka cannot work properly without ritonavir.
Slovenian: Brez ritonavirja zdravilo Darunavir Krka ne more pravilno delovati.
English: Therapy with darunavir/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with darunavir/cobicistat should be switched to an alternative regimen (see sections 4.2 and 4.4).
Slovenian: Zato se zdravljenja s kombinacijo darunavir/kobicistat ne sme uvesti med nosečnostjo, pri ženskah, ki med zdravljenjem s to kombinacijo zanosijo, pa je treba razmisliti o prehodu na drug režim zdravljenja (glejte poglavji 4.2 in 4.4).
English: EU/1/17/1249/005 30 film-coated tablets EU/1/17/1249/006 60 film-coated tablets EU/1/17/1249/007 90 film-coated tablets EU/1/17/1249/008 180 film-coated tablets
Slovenian: EU/1/17/1249/005 30 filmsko obloženih tablet EU/1/17/1249/006 60 filmsko obloženih tablet EU/1/17/1249/007 90 filmsko obloženih tablet EU/1/17/1249/008 180 filmsko obloženih tablet
English: 30 film-coated tablets: EU/1/17/1249/005 60 film-coated tablets: EU/1/17/1249/006 90 film-coated tablets: EU/1/17/1249/007 180 film-coated tablets: EU/1/17/1249/008
Slovenian: 30 filmsko obloženih tablet: EU/1/17/1249/005 60 filmsko obloženih tablet: EU/1/17/1249/006 90 filmsko obloženih tablet: EU/1/17/1249/007 180 filmsko obloženih tablet: EU/1/17/1249/008
English: Third trimester of pregnancy (n=12)
Slovenian: Tretje trimesečje nosečnosti (n = 12)
English: (CYP3A and/or P-gp inhibition).
Slovenian: (zaviranje CYP3A in/ali P-gp)
English: Darunavir Krka 600 mg film-coated tablets darunavir
Slovenian: Darunavir Krka 600 mg filmsko obložene tablete darunavir
English: ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17%
Slovenian: ANTIBIOTIKI klaritromicin 500 mg dvakrat na dan klaritromicin AUC ↑ 57 % klaritromicin Cmin ↑ 174 % klaritromicin Cmax ↑ 26 % darunavir AUC ↓ 13 % darunavir Cmin ↑ 1 % darunavir Cmax ↓ 17 % pri kombiniranju z zdraviloma darunavir/ritonavir koncentracije 14-hidroksi-klaritromicina niso bile zaznavne (↑ klaritromicina zaradi zaviranja CYP3A in verjetno tudi P-gp)
English: 375 milligram darunavir + 50 milligram ritonavir twice a day between 30 and 40 kilograms
Slovenian: 375 mg darunavirja + 50 mg ritonavirja dvakrat na dan
English: EU/1/17/1249/001 30 film-coated tablets EU/1/17/1249/002 60 film-coated tablets EU/1/17/1249/003 90 film-coated tablets EU/1/17/1249/004 180 film-coated tablets
Slovenian: EU/1/17/1249/001 30 filmsko obloženih tablet EU/1/17/1249/002 60 filmsko obloženih tablet EU/1/17/1249/003 90 filmsko obloženih tablet EU/1/17/1249/004 180 filmsko obloženih tablet
English: Darunavir should be used with caution in patients with a known sulphonamide allergy.
Slovenian: Pri uporabi darunavirja pri bolnikih z znano preobčutljivostjo za sulfonamide je potrebna previdnost.
English: Several of the interaction studies (indicated by
Slovenian: Preskušanje z uporabo darunavirja, označenega s
English: In contrast to these data with darunavir /ritonavir, darunavir/cobicistat may increase these antidepressant plasma concentrations (CYP2D6 and/or CYP3A inhibition).
Slovenian: V nasprotju s podatki za kombinacijo darunavir/ritonavir lahko kombinacija darunavir/kobicistat zviša plazemske koncentracije navedenih antidepresivov.
English: Darunavir Krka 400 mg film-coated tablets darunavir
Slovenian: Darunavir Krka 400 mg filmsko obložene tablete darunavir
English: Refer to section 4.4 if creatinine clearance is used for dose adjustment of tenofovir disoproxil.
Slovenian: Če očistek kreatinina uporabljate za prilagajanje odmerka dizoproksiltenofoviratom, glejte poglavje 4.4.
English: Emtricitabine/tenofovir alafenamide
Slovenian: emtricitabin/alafenamidtenofovirat alafenamidtenofovirat↔ tenofovir
English: Darunavir Krka 800 mg film-coated tablets darunavir
Slovenian: Darunavir Krka 800 mg filmsko obložene tablete darunavir
English: Common side effects (may affect up to 1 in 10 people) vomiting, nausea, abdominal pain or distension, dyspepsia, flatulence headache, tiredness, dizziness, drowsiness, numbness, tingling or pain in hands or feet, loss of strength, difficulty falling asleep.
Slovenian: dispepsija, napenjanje - glavobol, utrujenost, omotica, zaspanost, odrevenelost, mravljinčenje ali bolečina v rokah ali nogah, izguba moči, nezmožnost zaspati
English: Concomitant use of bosentan and darunavir co-administered with low dose ritonavir may increase plasma concentrations of bosentan.
Slovenian: Sočasna uporaba bosentana in darunavirja skupaj z majhnim odmerkom ritonavirja lahko zveča plazemske koncentracije bosentana.
English: high blood pressure, flushing red or dry eyes fever, swelling of lower limbs due to fluids, malaise, irritability, pain symptoms of infection, herpes simplex erectile dysfunction, enlargement of breasts sleeping problems, sleepiness, depression, anxiety, abnormal dreams, decrease in sexual drive
Slovenian: bolehnost, razdražljivost, bolečina - znaki okužbe, herpes simplex - motnje erekcije, zvečanje dojk - težave s spanjem, zaspanost, depresija, tesnoba, nenavadne sanje, zmanjšanje spolne sle
English: Darunavir is expected to increase these antipsychotic plasma concentrations.
Slovenian: Pričakovati je, da darunavir zviša plazemske koncentracije teh antipsihotikov.
English: Caution should be exercised when combining one of these antineoplastic agents with boosted darunavir.
Slovenian: Pri kombiniranju teh zdravil proti raku z okrepljenim darunavirjem je potrebna previdnost.
English: silica, colloidal anhydrous ) and magnesium stearate (E470b)in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) and red iron oxide (E172) in film coating.
Slovenian: - Druge sestavine zdravila so mikrokristalna celuloza, krospovidon, hidroksipropilceluloza, brezvodni koloidni silicijev dioksid, silicizirana mikrokristalna celuloza (mikrokristalna celuloza, brezvodni koloidni silicijev dioksid) in magnezijev stearat (E470b) v jedru tablete ter polivinilalkohol, makrogol, titanov dioksid (E171), smukec (E553b), rumeni železov oksid (E172) in rdeči železov oksid (E172) v filmski oblogi.
English: 600 mg darunavir/100 mg ritonavir once daily
Slovenian: 600 mg darunavirja/100 mg ritonavirja enkrat na dan
English: darunavir/ ritonavir 600/100 mg twice daily N=296
Slovenian: darunavir/ritonavir 600/100 mg dvakrat na dan n = 296
English: darunavir/ ritonavir 600/100 mg twice daily N=298
Slovenian: darunavir/ritonavir 600/100 mg dvakrat na dan n = 298
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with boosted darunavir is required.
Slovenian: Če bolniki z normalno ledvično ali jetrno funkcijo potrebujejo zdravljenje z okrepljenim darunavirjem, je priporočljivo zmanjšati odmerek kolhicina ali prekiniti zdravljenje z njim.
English: Pharmacokinetic results of total darunavir after administration of darunavir/cobicistat 800/150 mg once daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy, and postpartum Pharmacokinetics of total darunavir (mean ± SD)
Slovenian: Rezultati farmakokinetike celokupnega darunavirja po jemanju zdravil darunavir/ritonavir v odmerkih 800/100 mg enkrat na dan kot del protiretrovirusnega zdravljenja med drugim in tretjim trimesečjem nosečnosti ter v obdobju po porodu Farmakokinetika celokupnega darunavirja (povprečna vrednost ±
English: The pharmacokinetics of darunavir in combination with ritonavir taken once daily in 10 treatmentexperienced paediatric patients, aged 3 to < 6 years and weighing at least 14 kg to < 20 kg, showed that weight-based dosages resulted in darunavir exposure that was comparable to that achieved in adults receiving darunavir/ritonavir 800/100 mg once daily (see section 4.2).
Slovenian: Farmakokinetika darunavirja v kombinaciji z ritonavirjem enkrat na dan pri 10 pediatričnih bolnikih, starih 3 do < 6 let in s telesno maso najmanj 14 kg do < 20 kg, ki so se že zdravili z ART, je pokazala, da jemanje zdravil darunavir/ritonavir 800/100 mg enkrat na dan vodi v izpostavljenost darunavirju, ki je primerljiva izpostavljenosti, doseženi pri odraslih bolnikih, ki so prejemali 800/100 mg zdravil d arunavir/ritonavir enkrat na dan (glejte poglavje 4.2).
English: Systemic dexamethasone should be used with caution when combined with boosted darunavir.
Slovenian: Pri sočasni uporabi sistemsko danega deksametazona in okrepljenega darunavirja je potrebna previdnost.
English: Outcomes darunavir/ritonavir 600/100 mg twice daily + OBR N=298
Slovenian: Izidi darunavir/ritonavir 600/100 mg dvakrat na dan +OBR n = 298
English: Concomitant use of everolimus and darunavir co-administered with low dose ritonavir is not recommended.
Slovenian: Sočasna uporaba everolimusa in darunavirja skupaj z majhnim odmerkom ritonavirja ni priporočljiva.
English: 375 mg darunavir /50 mg ritonavir twice daily
Slovenian: 375 mg darunavirja/50 mg ritonavirja dvakrat na dan
English: Efavirenz in combination with darunavirmay result in sub-optimal darunavir Cmin.
Slovenian: Pri uporabi kombinacije zdravil efavirenz in darunavir se Cmin darunavirja lahko zniža pod optimalno vrednost.
English: Darunavir is metabolised by the hepatic system.
Slovenian: Darunavir se presnavlja v jetrih.
English: OTHER LIPID MODIFYING AGENTS Lomitapide
Slovenian: DRUGA ZDRAVILA Z VPLIVOM NA MAŠČOBE lomitapid
English: Oestrogen-based hormonal contraceptives and hormonal replacement therapy.
Slovenian: - hormonske kontraceptive z estrogenom in zdravila za nadomestno hormonsko zdravljenje; zdravilo Darunavir Krka bi lahko zmanjšalo njihovo učinkovitost.
English: darunavir/ritonavir 600/100 mg twice daily + OBR N=296
Slovenian: darunavir/ritonavir 600/100 mg dvakrat na dan + OBR n = 296
English: Darunavir Krka cannot work properly without food.
Slovenian: Brez hrane zdravilo Darunavir Krka ne more pravilno delovati.
English: Concomitant administration of boosted darunavir with dabigatran or ticagrelor is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba okrepljenega darunavirja in dabigatrana ali tikagrelorja je kontraindicirana (glejte poglavje 4.3).
English: Each film-coated tablet contains 600 mg darunavir.
Slovenian: Ena filmsko obložena tableta vsebuje 600 mg darunavirja.
English: Pharmacokinetic results of total darunavir after administration of darunavir/ritonavir at 800/100 mg once daily as part of an antiretroviral regimen, during the second trimester of pregnancy, the third trimester of pregnancy and postpartum
Slovenian: Rezultati farmakokinetike celokupnega darunavirja po jemanju zdravil darunavir/ritonavir v odmerkih 800/100 mg enkrat na dan kot del protiretrovirusnega zdravljenja med drugim in tretjim trimesečjem nosečnosti ter v obdobju po porodu
English: At 48 weeks non-inferiority in virologic response to the darunavir/ritonavir treatment, defined as the percentage of patients with plasma HIV-1 RNA level < 400 and < 50 copies/ml, was demonstrated (at the pre-defined 12% non-inferiority margin) for both ITT and OP populations.
Slovenian: Po 48 tednih so dokazali neinferiornost (pri vnaprej določeni 12 % meji neinferiornosti) virološkega odziva (določen kot odstotek bolnikov s plazemsko koncentracijo HIV-1 RNK < 400 in < 50 kopij/ml) na zdravljenje s kombinacijo darunavir/ritonavir tako za populacijo, ki je bila vključena v preskušanje (ITTIntent-To-Treat), kot tudi za populacijo, ki je preskušanje zaključila skladno s protokolom (OP - On Protocol).
English: In ART-experienced patients without DRV-RAMs* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Slovenian: - pri bolnikih z izkušnjami z ART, ki nimajo DRV-RAM*, in imajo plazemsko koncentracijo HIV-1 RNK < 100.000 kopij/ml in število celic CD4+ ≥ 100 celic x 10
English: (drug) hypersensitivity uncommon immune reconstitution inflammatory syndrome
Slovenian: občasni vnetni sindrom imunske obnove
English: The pharmacokinetic enhancing effect of pharmacokinetic enhancer other than ritonavir on darunavir was evaluated in a Phase I study in healthy subjects that were administered darunavir 800 mg with ritonavir at 100 mg or other phrmacokinetic enhancer once daily.
Slovenian: Učinek farmakokinetičnega ojačevalca, ki ni ritonavir, na darunavir so ocenili v študiji faze I pri zdravih prostovoljcih, ki so prejemali 800 mg darunavirja skupaj s 100 mg ritonavirja ali z drugim farmakokinetičnim ojačevalcem enkrat na dan. Parametri farmakokinetike darunavirja v stanju dinamičnega ravnovesja, okrepljenega z drugim farmakokinetičnim ojačevalcem, so bili primerljivi s parametri, pridobljenimi pri okrepitvi z ritonavirjem.
English: For further information on cobicistat, consult the cobicistat Summary of Product Characteristics.
Slovenian: Za dodatne podatke o kobicistatu glejte Povzetek glavnih značilnosti zdravila za kobicistat.
English: Each film-coated tablet contains 600mg darunavir.
Slovenian: Ena filmsko obložena tableta vsebuje 600mg darunavirja.
English: If efavirenz is to be used in combination with darunavir /ritonavir, the darunavir/ritonavir
Slovenian: sakvinavir/darunavir/ritonavir
English: Instructions for children 3 years of age and above, weighing more than 40 kilograms Take 800 milligram Darunavir Krka (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) at the same time, once a day, every day.
Slovenian: Navodila za otroke, stare 3 leta ali več in s telesno maso najmanj 40 kg - Vsak dan (enkrat na dan) vzemite 800mgzdravilaDarunavir Krka (dve tableti zdravila Darunavir Krka.
English: Concomitant use of darunavir coadministered wirth low dose ritonavir and these antidepressants may increase concentrations of the antidepressant.
Slovenian: Sočasna uporaba darunavirja skupaj z majhnim odmerkom ritonavirja z navedenimi antidepresivi lahko zviša njihove koncentracije.
English: Plasma concentrations of these medicinal products may be increased when co-administered with darunavir with low dose ritonavir, resulting in reduced serum cortisol concentrations.
Slovenian: Ob sočasni uporabi z darunavirjem skupaj z majhnim odmerkom ritonavirja se lahko plazemske koncentracije teh zdravil zvišajo, serumske koncentracije kortizola pa znižajo.
English: Darunavir KrKa 600 mg film coated tablets must not be chewed or crushed.
Slovenian: Tablet zdravila Darunavir Krka po 600 mg ne smete žvečiti ali zdrobiti.
English: Co-administration of boosted Clinical monitoring is recommended darunavir with clonazepam may increase concentrations of clonazepam.
Slovenian: Sočasna uporaba okrepljenega darunavirja s klonazepamom lahko zviša koncentracije klonazepama.
English: Boosted darunavir can be coadministered with proton pump inhibitors without dose adjustments.
Slovenian: Okrepljen darunavir lahko uporabljamo sočasno z zaviralci protonske črpalke, brez prilagajanja odmerka.
English: Lovastatin and simvastatin are expected to have markedly increased plasma concentrations when coadministered with boosted darunavir.
Slovenian: Zvišanje plazemskih koncentracij lovastatina in simvastatina lahko pričakujemo izrazito zvečanje plazemskih koncentracij lovastatina in simvastatina.
English: Boosted darunavir can be used with these NRTIs without dose adjustment.
Slovenian: Okrepljen darunavir lahko uporabljate z rilpivirinom brez prilagajanja odmerkov.
English: Concominant use of everolimus or irinotecan and boosted darunavir is not recommended.
Slovenian: Sočasna uporaba everolimusa ali irinotekana z okrepljenim darunavirjem ni priporočljiva.
English: Musculoskeletal and connective tissue disorders uncommon myalgia, osteonecrosis, muscle spasms, muscular weakness, arthralgia, pain in extremity, osteoporosis, increased blood creatine phosphokinase rare musculoskeletal stiffness, arthritis, joint stiffness
Slovenian: DRESS, Stevens-Johnsonov sindrom, multiformni eritem, dermatitis, seboreični dermatitis, razjede na koži, kseroderma neznana pogostnost toksična epidermalna nekroliza, akutna generalizirana eksantemska pustuloza Bolezni mišično-skeletnega sistema in vezivnega tkiva občasni mialgija, osteonekroza, mišični krči, šibkost mišic, artralgija, bolečine v udih, osteoporoza, povišanje kreatin fosfokinaze v krvi redki mišično-skeletna okorelost, artritis, okorelost sklepov
English: The combination of avanafil and boosted darunavir is contraindicated (see section 4.3).
Slovenian: Kombinacija avanafila in okrepljenega darunavirja je kontraindicirana (glejte poglavje 4.3).
English: When administration of rosuvastatin and darunavir co-administered with low dose ritonavir is required, it is recommended to start with the lowest possible dose of rosuvastatin and titrate up to the desired clinical effect while monitoring for safety.
Slovenian: Če je potrebna sočasna uporaba rosuvastatina in darunavirja skupaj z majhnim odmerkom ritonavirja, je priporočljivo, da zdravljenje začnete z najnižjim možnim odmerkom rosuvastatina, ki ga nato, ob spremljanju varnosti, zvečujete do kliničnega učinka.
English: Not studied with darunavir/ritonavir.
Slovenian: s kombinacijo darunavir/ritonavir
English: Brownish red, oval, biconvex film-coated tablets (tablets), engraved with a mark S3 on one side.
Slovenian: Rjavkasto rdeče, ovalne, izbočene filmsko obložene tablete (tablete) z vtisnjeno oznako S3 na eni strani.
English: It is recommended that the international normalised ratio (INR) be monitored when warfarin is combined with boosted darunavir.
Slovenian: Ob sočasni uporabi varfarina in okrepljenega darunavirja se priporoča spremljanje vrednosti mednarodno normaliziranega razmerja (INR - International Normalised Ratio).
English: These active substances include e.g.: alfuzosin amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine astemizole, terfenadine colchicine when used in patients with renal and/or hepatic impairment (see section 4.5) ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine) elbasvir/grazoprevir cisapride dapoxetine domperidone naloxegol lurasidone, pimozide, quetiapine, sertindole (see section 4.5) triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5) sildenafil -when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5).
Slovenian: - alfuzosin - amjodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin - astemizol, terfenadin - kolhicin, kadar se uporablja pri bolnikih z okvaro ledvic/jeter (glejte poglavje 4.5) - alkaloidi ergot (npr. dihidroergotamin, ergonovin, ergotamin in metilergonovin) - elbasvir/grazoprevir - cisaprid
English: Patients with coexisting conditions
Slovenian: Bolniki z drugimi boleznimi ali motnjami
English: Co-administration with strong CYP3A4 inhibitors is not recommended and caution is warranted, these interactions are described in the interaction table below (e.g. indinavir, azole antifungals like clotrimazole).
Slovenian: Te interakcije so opisane v spodnji preglednici (npr. indinavir, protiglivični azoli kot je ketokonazol in klotrimazol).
English: 800 milligram Darunavir Krka (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) together with 100 milligram ritonavir once daily.
Slovenian: Odmerek je lahko: - 800mgzdravila Darunavir Krka (dve tableti zdravila Darunavir Krka po 400mg ali ena tableta zdravila Darunavir Krka po 800 mg) skupaj s 100 mg ritonavirja enkrat na dan. ALI - 600mgzdravila Darunavir Krka (ena tableta zdravilaDarunavir Krka po 600 mg) skupaj s 100 mg ritonavirja dvakrat na dan.
English: ART-experienced with no darunavir resistance associated mutations (DRV-RAMs) and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Slovenian: - z izkušnjami z ART, ki nimajo mutacij, povezanih z odpornostjo proti darunavirju (DRV-RAM - darunavir resistance associated mutations), in imajo plazemsko koncentracijo HIV-1 RNK < 100.000 kopij/ml in število celic CD4+ ≥ 100 celic x 6/l.
English: Darunavir was evaluated for carcinogenic potential by oral gavage administration to mice and rats up to 104 weeks.
Slovenian: Kancerogeni potencial darunavirja so določili pri miših in podganah.
English: Yellowish brown, oval, biconvex film-coated tablets (tablets), engraved with a mark S1 on one side.
Slovenian: Rumenkasto rjave, ovalne, izbočene filmsko obložene tablete (tablete) z vtisnjeno oznako S1 na eni strani.
English: Non-completer is failure imputation: patients who discontinued prematurely are imputed with a change equal to 0.
Slovenian: Zmanjšanje kopij v plazmi za ≥ 1,0 log10 glede na začetno vrednost pripisane vrednosti, izračunane z uporabo algoritma TLOVR bolniki, ki niso dokončali preskušanja, so označeni kot neuspešni: bolnikom, ki so predčasno prenehali sodelovati v preskušanju, so pripisali vrednost spremembe 0
English: When administration of pravastatin and darunavir co-administered with low dose ritonavir is required, it is recommended to start with the lowest possible dose of pravastatin and titrate up to the desired clinical effect while monitoring for safety.
Slovenian: Če je potrebna sočasna uporaba pravastatina in darunavirja skupaj z majhnim odmerkom ritonavirja, je priporočljivo, da zdravljenje začnete z najnižjim možnim odmerkom pravastatina, ki ga nato, ob spremljanju varnosti, zvečujete do kliničnega učinka.
English: In all other ART-experienced patients or if HIV-1 genotype testing is not available, the recommended dose regimen is 600 mg twice daily taken with ritonavir 100 mg twice daily taken with food.
Slovenian: Darunavir Krka 400 mg in 800 mg tablete lahko uporabljate za režim odmerjanja 800 mg enkrat na dan. - pri vseh drugih bolnikih z izkušnjami z ART, pri katerih ni rezultatov testiranja genotipa, je priporočeno odmerjanje 600 mg darunavirja dvakrat na dan, skupaj s 100 mg ritonavirja dvakrat na dan, s hrano.
English: For information on cobicistat, consult the cobicistat Summary of Product Characteristics.
Slovenian: Za podatke o kobicistatu glejte Povzetek glavnih značilnosti zdravila za kobicistat.
English: TITAN is a randomised, controlled, open-label Phase III trial comparing darunavir co-administered with ritonavir (600/100 mg twice daily) versus lopinavir/ritonavir (400/100 mg twice daily) in ARTexperienced, lopinavir naïve HIV-1 infected adult patients.
Slovenian: V njem primerjajo kombinacijo darunavirja z ritonavirjem (600/100 mg dvakrat na dan) s kombinacijo učinkovin lopinavir/ritonavir (400/100 mg dvakrat na dan) pri odraslih bolnikih, okuženih s HIV-1, z izkušnjami z ART, ki še niso prejemali lopinavirja.
English: Concomitant use of other PDE-5 inhibitors for the treatment of erectile
Slovenian: Pri sočasni uporabi zaviralcev PDE-5 (za zdravljenje majhnim odmerkom ritonavirja primerljiva.