FrancophonIA/ELRC3.0 huggingface dataset:
English: However, a reduction in blood pressure can occur in individual patients, leading in rare cases to syncope.
Slovenian: Vendar pa se pri posameznih bolnikih lahko pojavi znižanje krvnega tlaka, ki v redkih primerih lahko vodi do sinkope (omedlevice).
English: • If you have problems with your kidneys, please ask your doctor for advice.
Slovenian: • Če imate težave z ledvicami, prosite za nasvet svojega zdravnika.
English: Patients taking PDE-5 inhibitors concomitantly with silodosin should be monitored for possible adverse reactions.
Slovenian: Bolnike, ki jemljejo zaviralce PDE-5 sočasno s silodozinom, je treba zaradi možnih neželenih učinkov nadzorovati.
English: At the first signs of orthostatic hypotension (such as postural dizziness), the patient should sit or lie down until the symptoms have disappeared.
Slovenian: Ob prvih znakih ortostatske hipotenzije (kot je posturalna omotičnost) naj bolnik sede ali leže, dokler simptomi ne izginejo.
English: The European Medicines Agency has waived the obligation to submit the results of studies with the reference medicinal product containing silodosin in all subsets of the paediatric population in BPH (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij z referenčnim zdravilom, ki vsebuje silodozin, za vse podskupine pediatrične populacije z BHP (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Obstructive symptoms
Slovenian: Obstrukcijski simptomi
English: Silodosin has a volume of distribution of 0.81 L/kg and is 96.6% bound to plasma proteins.
Slovenian: Silodozin ima volumen porazdelitve 0,81 l/kg, vezava na beljakovine plazme je 96,6%.
English: ANNEX II A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Slovenian: A. IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET
English: Do not drive or operate machines if you feel faint, dizzy, drowsy or have blurred vision.
Slovenian: Ne vozite avtomobila in ne upravljajte strojev, če občutite omedlevico, omotico, zaspanost ali če imate motnje vida.
English: Since only limited experience exists in patients with moderate renal impairment (n = 35), a lower starting dose of 4 mg is recommended.
Slovenian: Ker so izkušnje pri bolnikih z zmerno okvaro delovanja ledvic le omejene (n = 35), je priporočljiv nižji začetni odmerek 4 mg.
English: Concomitant use with potent CYP3A4 inhibitors (such as ketoconazole, itraconazole, ritonavir or cyclosporine) is not recommended.
Slovenian: Sočasna uporaba z močnimi zaviralci CYP3A4 (kot so ketokonazol, itrakonazol, ritonavir ali ciklosporin) ni priporočljiva.
English: Blockade of these α1A-adrenoreceptors causes smooth muscle in these tissues to relax, thus decreasing bladder outlet resistance, without affecting detrusor smooth muscle contractility.
Slovenian: Blokada α1A adrenergičnih receptorjev povzroči sprostitev gladkih mišic v teh tkivih, s čimer se zmanjša izpustni odpor mehurja, ne da bi vplivala na krčljivost gladkih mišic detruzorja.
English: In the clinical study program, many patients were on concomitant antihypertensive therapy (mostly agents acting on the renin-angiotensin system, beta-blockers, calcium antagonists and diuretics) without experiencing an increase in the incidence of orthostatic hypotension.
Slovenian: V kliničnem študijskem programu so se številni bolniki sočasno zdravili z antihipertenzivi (večinoma z učinkovinami, ki delujejo na sistem renin-angiotenzin, beta-blokatorji, kalcijevimi antagonisti in diuretiki), ne da bi prišlo do porasta pojavnosti ortostatske hipotenzije.
English: Effects in animals (affecting the thyroid gland in rodents) were observed only at exposures considered sufficiently in excess of the maximum human exposure, indicating little relevance to clinical use.
Slovenian: Učinke na živalih (na žlezi ščitnici pri glodalcih) so opazili samo pri izpostavljenosti, ki je močno presegala največjo izpostavljenost pri človeku, kar kaže na majhen pomen za klinično uporabo.
English: Silodosin is also a substrate for P-glycoprotein.
Slovenian: Silodozin je tudi substrat za P-glikoprotein.
English: If you have moderate kidney problems, your doctor may prescribe a different dose.
Slovenian: Če imate zmerne težave z delovanjem ledvic, vam bo zdravnik morda predpisal drugačen odmerek.
English: Data observed in the Intent-to-treat populations of each study are shown below:
Slovenian: Prikazani so podatki za populacijo vseh vključenih bolnikov, za vse študije:
English: Results from this study should be interpreted with caution, since enrolled patients had normal biochemistry values, indicating normal metabolic function, and they were classified as having moderate liver impairment based on ascites and hepatic encephalopathy.
Slovenian: Rezultate te študije je treba interpretirati previdno, saj so bile vrednosti biokemijskih preiskav pri vključenih bolnikih normalne, kar kaže na normalno delovanje presnove, kot bolnike z zmerno okvarjenim delovanjem jeter pa so jih opredelili na podlagi ascitesa in protokavalne encefalopatije.
English: If you are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Slovenian: Če načrtujete otroka, se pred začetkom jemanja tega zdravila posvetujte z zdravnikom ali farmacevtom.
English: Patients should be informed about the possible occurrence of symptoms related to postural hypotension (such as dizziness) and should be cautioned about driving or operating machines until they know how silodosin will affect them.
Slovenian: Vseeno je treba bolnike opozoriti na možne simptome, povezane s posturalno hipotenzijo (kot je omotičnost) in na potrebno previdnost pri vožnji ali upravljanju strojev, dokler ne ugotovijo, kako bo silodozin vplival nanje.
English: Silodosin Recordati has minor or moderate influence on the ability to drive and use machines.
Slovenian: Zdravilo Silodosin Recordati ima blag ali zmeren vpliv na sposobnost vožnje in upravljanja strojev.
English: Titanium dioxide (E171) Yellow iron oxide (E172) (4 mg capsules only)
Slovenian: Ovojnica kapsule želatina titanov dioksid (E171) rumeni železov oksid (E172) (samo 4 mg kapsula)
English: Irritative symptoms
Slovenian: Iritacijski simptomi
English: Silodosin has a substantially lower affinity for the α1B-adrenoreceptors that are primarily located in the cardiovascular system.
Slovenian: Silodozin ima znatno manjšo afinitieto za α1B adrenergične receptorje, ki se prvenstveno nahajajo v srčno-žilnem sistemu.
English: By blocking these receptors, it causes smooth muscle in these tissues to relax.
Slovenian: Z blokado teh receptorjev povzroči sprostitev gladkih mišic v teh tkivih.
English: In male rats, decreased fertility was observed from exposures which were approximately twice the exposure at the maximum recommended human dose.
Slovenian: Pri podganjih samčkih so od izpostavitve, ki je približno dvakrat presegala najvišji priporočeni odmerek za človeka, opazili zmanjšano plodnost.
English: Exposure to the main metabolites, silodosin glucuronide and KMD3293, was also increased.
Slovenian: Povečana je bila tudi izpostavitev glavnima presnovkoma, glukuronidni konjugat silodozina in KMD-3293.
English: Approximately half of the patients reported an improvement in the most bothersome symptoms complained at baseline by the patients (i.e. nocturia, frequency, decreased stream, urgency, terminal dribbling and incomplete emptying), as assessed by the ICS-male questionnaire.
Slovenian: Približno polovica bolnikov je poročala o izboljšanju najbolj nadležnih simptomov, nad katerimi so se bolniki pritoževali ob izhodišču (tj. nokturija, pogostnost, manjši curek, nuja, končno kapljanje in nepopolna izpraznitev), kot je bilo ocenjeno z vprašalnikom za moške Mednarodnega združenja za inkontinenco (ICS, International Continence Society).
English: This medicine contains less than 1 mmoL sodium (23 mg) per capsule, that is to say essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na kapsulo, kar v bistvu pomeni ‘brez natrija'.
English: Silodosin Recordati is available in packs containing 10, 20, 30, 50, 90, 100 capsules.
Slovenian: Zdravilo Silodosin Recordati je na voljo v pakiranjih po 10, 20, 30, 50, 90, 100 kapsul.
English: This causes an improvement of both storage (irritative) and voiding (obstructive) symptoms (Lower urinary tract symptoms, LUTS) associated with benign prostatic hyperplasia.
Slovenian: To povzroči izboljšanje tako iritacijskih kot tudi obstrukcijskih simptomov (neprijetnih simptomov mokrenja; LUTS - Lower urinary tract symptoms), povezanih z benigno hiperplazijo prostate.
English: What Silodosin Recordati is and what it is used for What you need to know before you take Silodosin Recordati How to take Silodosin Recordati Possible side effects
Slovenian: Kaj je zdravilo Silodosin Recordati in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Silodosin Recordati Kako jemati zdravilo Silodosin Recordati Možni neželeni učinki
English: If it is almost time for the next dose, skip the dose you missed.
Slovenian: Če se že bliža čas, ko bi morali vzeti naslednji odmerek, izpuščeni odmerek izpustite.
English: An in vitro study with Caco-2 cells showed that silodosin is a substrate for P-glycoprotein.
Slovenian: In vitro študija s Caco-2 celicami je pokazala, da je silodozin substrat P-glikoproteina.
English: Digital rectal examination and, when necessary, determination of prostate specific antigen (PSA) should be performed before treatment and at regular intervals afterwards.
Slovenian: Pred zdravljenjem in nato v rednih intervalih je treba opraviti digitalni pregled rektuma in po potrebi določiti za prostato specifični antigen (PSA).
English: Within each frequency grouping the observed adverse reactions are presented in order of decreasing seriousness.
Slovenian: V razvrstitvah pogostnosti so opaženi neželeni učinki navedeni po padajoči resnosti.
English: Substances that inhibit (such as ketoconazole, itraconazole, ritonavir or cyclosporine) or induce (such as rifampicin, barbiturates, carbamazepine, phenytoin) these enzymes and transporters may affect the plasma concentrations of silodosin and its active metabolite.
Slovenian: Zdravila, ki zavirajo (kot so ketokonazol, intrakonazol, ritonavir ali ciklosporin) ali inducirajo (kot so rifampicin, barbiturati, karbamazepin, fenitoin) te encime in prenašalce, lahko vplivajo na plazemske koncentracije silodozina in njegovega aktivnega presnovka.
English: 10 hard capsules 20 hard capsules 30 hard capsules 50 hard capsules 90 hard capsules 100 hard capsules
Slovenian: 10 trdih kapsul 20 trdih kapsul 30 trdih kapsul 50 trdih kapsul 90 trdih kapsul 100 trdih kapsul
English: It is important that you immediately inform your eye specialist if you are using or have previously used Silodosin Recordati.
Slovenian: Pomembno je, da takoj obvestite svojega očesnega zdravnika, če uporabljate ali ste v preteklosti uporabljali zdravilo Silodosin Recordati.
English: • If you have ever fainted or felt dizzy when suddenly standing up, please inform your doctor before taking Silodosin Recordati.
Slovenian: • Če ste kdajkoli omedleli ali občutili omotico ob nenadnem vstajanju v pokončni položaj, povejte svojemu zdravniku pred pričetkom jemanja zdravila Silodosin Recordati.
English: Common Uncommon Rare
Slovenian: Neznana pogostnost
English: Silodosin is excreted mainly as metabolites, very low amounts of unchanged drug are recovered in urine.
Slovenian: Silodozin se pretežno izloča v obliki presnovkov, z urinom se izločijo zelo majhne količine nespremenjenega zdravila.
English: No dose adjustment is required in the elderly (see section 5.2).
Slovenian: Pri starejših bolnikih prilagajanje odmerka ni potrebno (glejte poglavje 5.2).
English: Carcinoma of the prostate
Slovenian: Karcinom prostate
English: If dizziness when standing up or fainting occurs, please inform your doctor as soon as possible.
Slovenian: Če se ob vstajanju v pokončni položaj pojavi omotica ali omedlevica, čim prej obvestite svojega zdravnika.
English: The capsules are provided in PVC/PVDC/aluminium foil blisters, packed in cartons.
Slovenian: Kapsule so na voljo v pretisnih omotih iz PVC/PVDC/aluminijaste folije, pakiranih v škatli.
English: In all studies, patients who did not respond to placebo during a 4-week placebo run-in phase were randomised to receive the study treatment.
Slovenian: V vseh študijah so bolnike, ki se v 4-tedenski fazi uvajanja, izvedeni s placebom, niso odzvali na placebo, randomizirali v skupine, ki so prejemale preiskovano zdravilo.
English: Silodosin administered orally is well absorbed and absorption is dose proportional.
Slovenian: Po peroralnem vnosu se silodozin dobro absorbira, absorpcija je sorazmerna z odmerkom.
English: Diarrhoea Nausea Dry mouth
Slovenian: Bolezni prebavil driska slabost suha usta
English: Silodosin 8 mg and 24 mg daily had no statistically significant effect on ECG intervals or cardiac repolarisation relative to placebo.
Slovenian: Silodozin v odmerku 8 mg oziroma 24 mg v primerjavi s placebom ni imel statistično pomembnega učinka na EKG intervale ali repolarizacijo srca.
English: Silodosin is metabolised extensively, mainly via CYP3A4, alcohol dehydrogenase and UGT2B7.
Slovenian: Silodozin se obsežno presnavlja, pretežno preko encimov CYP3A4, alkohol-dehidrogenaze in UGT2B7.
English: In the subjects over 65 years, the mean decreases at the various time points were between 5 and 15 mmHg (systolic) and 0 and 10 mmHg (diastolic).
Slovenian: Pri osebah, starejših od 65 let, so srednji padci krvnega tlaka, merjeni ob različnih časih, znašali od 5 do 15 mm Hg (sistolični) in od 0 do 10 mm Hg (diastolični).
English: Silodosin and its glucuronide reach steady-state after 3 days and 5 days of treatment, respectively.
Slovenian: Silodozin in njegov glukuronid dosežeta stanje dinamičnega ravnotežja po 3 oziroma po 5 dneh.
English: Urticaria1
Slovenian: urtikarija1
English: Silodosin Recordati may cause complications during a cataract surgery (eye surgery because of cloudiness of the lens, see section “Warnings and precautions”).
Slovenian: Zdravilo Silodosin Recordati lahko povzroči zaplete med operacijo sive mrene (operacija očesa zaradi zamotnitve leče, glejte poglavje »Opozorila in previdnostni ukrepi«).
English: The incidence of orthostatic hypotension in placebo-controlled clinical studies was 1.2% with silodosin and 1.0% with placebo.
Slovenian: V s placebom nadzorovanih kliničnih študijah je bila pogostnost ortostatske hipotenzije ob uporabi silodozina 1,2% in ob uporabi placeba 1,0%.
English: During pre-operative assessment, eye surgeons and ophthalmic teams should consider whether patients scheduled for cataract surgery are being or have been treated with silodosin, in order to ensure that appropriate measures will be in place to manage IFIS during surgery.
Slovenian: Očesni kirurgi in oftalmološke skupine morajo med pripravo na operacijo preveriti, če se bolniki, ki so predvideni za operacijo sive mrene, zdravijo ali so se zdravili s silodozinom, da bi lahko pripravili vse potrebno za obvladovanje IFIS med operacijo.
English: In healthy male subjects of the target age range (n = 16, mean age 55 ± 8 years) after once-a-day oral administration of 8 mg immediately after breakfast for 7 days, the following pharmacokinetic parameters were obtained: Cmax 87 ± 51 ng/mL (sd), tmax 2.5 hours (range 1.0-3.0), AUC 433 ± 286 ng • h/mL.
Slovenian: Pri zdravih moških v starosti ciljne skupine (n = 16, povprečna starost 55 ± 8 let) so bili po peroralnem vnosu 8 mg enkrat na dan takoj po zajtrku v obdobju 7 dni izmerjeni sledeči farmakokinetični parametri: Cmax 87 ± 51 ng/ml (SD), tmax 2,5 uri (razpon 1,0-3,0), AUC 433 ± 286 ng • h/ml.
English: The most frequent adverse reactions reported with silodosin in placebo controlled clinical studies and during long-term use were ejaculatory disorders such as retrograde ejaculation and anejaculation (ejaculatory volume reduced or absent), with a frequency of 23%.
Slovenian: Najpogostejši neželeni učinki, o katerih so poročali ob uporabi silodozina v s placebom nadzorovanih kliničnih študijah in ob dolgoročni uporabi, so bile je bile motnje ejakulacije kot je retrogradna ejakulacija in anejakulacija (zmanjšana količina ejakulata ali brez njega), s pogostnostjo 23%.
English: Should overdose of silodosin lead to hypotension, cardiovascular support has to be provided.
Slovenian: Če prevelik odmerek silodozina vodi v hipotenzijo, je treba zagotoviti ustrezno podporo srčno-žilnemu sistemu.
English: This may lead to increased procedural complications during the operation.
Slovenian: To lahko poveča tveganje za morebitne zaplete med posegom.
English: Dizziness when standing up and occasionally fainting may occur when taking Silodosin Recordati, particularly when starting treatment or if you are taking other medicines that lower blood pressure.
Slovenian: Ob jemanju zdravila Silodosin Recordati se lahko pojavita omotica ob vstajanju v pokončni položaj in občasno tudi omedlevica, še zlasti na začetku zdravljenja ali če jemljete druga zdravila za zniževanje krvnega tlaka.
English: In a Phase IV clinical trial performed in Europe, with a mean baseline IPSS total score of 18.9 points, 77.1%were responders to silodosin (as assessed by a change from baseline in the IPSS total score of at least 25%).
Slovenian: V klinični študiji IV. Faze, izpeljani v Evropi, s povprečnim izhodiščnim rezultatom vprašalnika IPSS 18,9 točk, se je 77,1%, bolnikov odzvalo na silodozin (kot je bilo ocenjeno s spremembo izhodiščnega rezultata vprašalnika IPSS za vsaj 25%).
English: Do not take Silodosin Recordati if you are allergic to silodosin or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Silodosin Recordati Ne jemljite zdravila Silodosin Recordati če ste alergični na silodozin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Total score
Slovenian: Celokupni rezultat
English: • medicines for epilepsy or rifampicin (a medicine to treat tubercolosis), since the effect of Silodosin Recordati may be reduced.
Slovenian: • zdravila za zdravljenje epilepsije ali rifampicin (zdravilo za zdravljenje tuberkuloze), ker se učinek zdravila Silodosin Recordati lahko zmanjša.
English: Silodosin Recordati may reduce the amount of sperm, and so could temporarily affect your ability to father a child.
Slovenian: Zdravilo Silodosin Recordati lahko zmanjša količino sperme, zaradi česar lahko začasno vpliva na sposobnost zaploditve otroka.
English: • If you have severe liver problems, you should not take Silodosin Recordati, as it was not tested in this condition.
Slovenian: • Če imate hude težave z jetri, ne smete jemati zdravila Silodosin Recordati, ker zdravilo pri takih bolnikih ni bilo preizkušeno.
English: Protein binding of silodosin glucuronide is 91%.
Slovenian: Vezava na beljakovine pri glukuronidnemu konjugatu silodozina je 91%.
English: Alpha-blockers There is inadequate information about the safe use of silodosin in association with other α-adrenoreceptor antagonists.
Slovenian: Blokatorji alfa Podatki o varni uporabi silodozina v povezavi z drugimi antagonisti α-adrenergičnih receptorjev so nezadostni.
English: Silodosin Recordati belongs to a group of medicines called alpha1A-adrenoreceptor blockers.
Slovenian: Silodosin Recordati sodi v skupino zdravil, imenovanih zaviralci alfa1A-adrenergičnih receptorjev.
English: In subjects with severe renal impairment (n = 5) increase of exposure was 2.2-fold for Cmax and 3.7-fold for AUC.
Slovenian: Pri bolnikih s hudo okvaro delovanja ledvic (n = 5) se je Cmax ob izpostavitvi povečala za 2,2-krat in AUC za 3,7-krat.
English: Body clearance of silodosin was approximately 0.28 L/h/kg.
Slovenian: Očistek silodozina je bil približno 0,28 l/h/kg.
English: For special patient populations, one capsule of Silodosin Recordati 4 mg daily is recommended (see below).
Slovenian: Pri posebnih skupinah bolnikov je priporočena ena kapsula zdravila Silodosin Recordati 4 mg na dan (glejte spodaj).
English: • If you are undergoing eye surgery because of cloudiness of the lens (cataract surgery), it is important that you immediately inform your eye specialist that you are using or have previously used Silodosin Recordati.
Slovenian: • Če se pripravljate na očesno operacijo zaradi zamotnitve očesne leče (katarakta, operacija sive mrene), je pomembno, da takoj poveste svojemu očesnemu zdravniku, da uporabljate ali ste uporabljali zdravilo Silodosin Recordati.
English: In the long-term open-label extension phase of these controlled studies, in which patients received silodosin for up to 1 year, the symptom improvement induced by silodosin at week 12 of treatment was maintained over 1 year.
Slovenian: V dolgoročni odprti podaljšani fazi teh nadzorovanih študij so bolniki prejemali silodozin do 1 leta.
English: Silodosin Recordati is not intended for use by women.
Slovenian: Zdravilo Silodosin Recordati ni namenjeno ženskam.
English: • Symptoms of allergic reaction affecting the skin like rash, itching, hives and rash caused by a medicine
Slovenian: • simptomi alergijske reakcije, ki prizadenejo kožo, na primer izpuščaj, srbenje, koprivnica in medikamentni izpuščaj
English: • Faster heart rate
Slovenian: • hitrejše bitje srca
English: A starting dose of 4 mg once daily is recommended in patients with moderate renal impairment (CLCR 30 to < 50 mL/min), which may be increased to 8 mg once daily after one week of treatment, depending on the individual patient's response.
Slovenian: Pri bolnikih z zmerno okvaro delovanja ledvic (CLCR ≥ 30 do < 50 ml/min) je priporočljivo uporabiti začetni odmerek 4 mg enkrat na dan, ki se ga glede na odziv posameznega bolnika po enem tednu zdravljenja lahko poveča na 8 mg enkrat na dan.
English: • antifungal medicines (such as ketoconazole or itraconazole), medicines used for HIV-AIDS (such as ritonavir) or medicines used after transplants to prevent organ rejection (such as cyclosporin) because these medicines can increase the blood concentration of Silodosin Recordati.
Slovenian: • zdravila proti glivicam (kot sta ketokonazol ali itrakonazol), zdravila za zdravljenje okužbe z virusom HIV/AIDS (kot je ritonavir) ali zdravila, ki se uporabljajo po presaditvi organov za preprečevanje zavrnitve organa (kot je ciklosporin), ker ta zdravila lahko zvišajo koncentracijo zdravila Silodosin Recordati v krvi.
English: In a placebo-controlled study in 24 subjects 45-78 years of age receiving silodosin, the co-administration of sildenafil 100 mg or tadalafil 20 mg induced no clinically meaningful mean decreases in systolic or diastolic blood pressure, as assessed by orthostatic tests (standing versus supine).
Slovenian: V s placebom nadzorovani študiji pri 24 osebah v starosti od 45-78 let, ki so jemale silodozin, sočasno zaužitje 100 mg sildenafila ali 20 mg tadalafila ni povzročilo klinično pomembnih srednjih padcev sistoličnega ali diastoličnega krvnega tlaka, kar so ocenili z ortostatskimi testi (v stoječem položaju v primerjavi s položajem leže na hrbtu).
English: Nevertheless, caution should be exercised when starting concomitant use with antihypertensives and patients should be monitored for possible adverse reactions.
Slovenian: Vseeno je na začetku zdravljenja sočasno z antihipertenzivi potrebna previdnost in bolnike je treba zaradi možnih neželenih učinkov nadzorovati.
English: The main metabolite in plasma, the glucuronide conjugate of silodosin (KMD-3213G), that has been shown to be active in vitro, has an extended half-life (approximately 24 hours) and reaches plasma concentrations approximately four times higher than those of silodosin.
Slovenian: Glavni plazemski presnovek, glukuronidni konjugat silodozina (KMD-3213G), za katerega se je izkazalo, da je in vitro aktiven, ima podaljšano razpolovno dobo (približno 24 ur) in doseže približno štirikrat višje plazemske koncentracije kakor silodozin.