FrancophonIA/ELRC3.0 huggingface dataset:
English: In healthy women receiving 12 mg (but not 4 or 8 mg/day) for 21 days concomitantly with a combined oral contraceptive, Fycompa was shown to decrease the levonorgestrel exposure (mean Cmax and AUC values were each decreased by 40%).
Danish: Hos raske kvinder, der fik Fycompa ved en dosis på 12 mg (men ikke 4 eller 8 mg/dag) i 21 dage samtidig med oral kontraception af kombinationstypen, blev det vist, at Fycompa nedsatte eksponeringen af levonorgestrel (gennemsnitlige Cmax- og AUC-værdier blev begge reduceret med 40 %).
English: Tell your doctor if you are taking midazolam as your dose may need to be adjusted.
Danish: Fortæl altid lægen, hvis du tager midazolam, da det kan være nødvendigt at justere din dosis.
English: A 19-week, randomised, double-blind, placebo-controlled study with an open-label extension phase (Study 235) was performed to assess the short-term effects on cognition of Fycompa (target dose range of 8 to 12 mg once daily) as adjunctive therapy in 133 (Fycompa n = 85, placebo n = 48) adolescent patients, ages 12 to less than 18 years old, with inadequately controlled partial-onset seizures.
Danish: Et 19-ugers, randomiseret, dobbeltblindet, placebokontrolleret studie med en åben forlængelsesfase (studie 235) blev udført for at vurdere Fycompas korttidsvirkninger på kognitiv funktion (målområde for dosis 8 til 12 mg én gang dagligt) som tillægsbehandling hos 133 (Fycompa n = 85, placebo n = 48) unge patienter i alderen 12 til under 18 år med utilstrækkeligt kontrollerede partielle anfald.
English: Perampanel is readily absorbed after oral administration with no evidence of marked first-pass metabolism.
Danish: Perampanel absorberes let efter oral administration uden evidens for en udpræget first-passmetabolisme.
English: Based on the clinical trial database of 196 adolescents exposed to perampanel from double-blind studies for partial-onset seizures and primary generalised tonic-clonic seizures, the overall safety profile in adolescents was similar to that of adults, except for aggression, which was observed more frequently in adolescents than in adults.
Danish: Baseret på databasen over kliniske studier med data fra 196 unge, der blev eksponeret for perampanel i dobbeltblinde studier med patienter med partielle anfald og primære generaliserede tonisk-kloniske anfald, svarede den overordnede sikkerhedsprofil hos unge til sikkerhedsprofilen hos voksne med undtagelse af aggression, som sås hyppigere hos unge end hos voksne.
English: The 50% responder rates in the 4 mg, 8 mg and 12 mg groups were respectively 23.0%, 31.5%, and 30.0% in combination with enzyme-inducing anti-epileptic medicinal products and were 33.3%, 46.5% and 50.0% when perampanel was given in combination with non-enzyme-inducing anti-epileptic medicinal products.
Danish: 50 %-responsraterne hos grupperne med 4 mg, 8 mg og 12 mg var hhv. 23,0 %, 31,5 % og 30,0 % ved kombination med enzyminducerende antiepileptika og hhv. 33,3 %, 46,5 % og 50,0 %, hvis perampanel blev givet i kombination med ikke-enzyminducerende antiepileptika.
English: Multiple dosing of perampanel 12 mg/day also enhanced the effects of alcohol on vigilance and alertness, and increased levels of anger, confusion and depression as assessed using the Profile of Mood State 5-point rating scale.
Danish: Gentagen dosering med perampanel 12 mg/dag forstærkede også alkohols virkning på årvågenhed og opmærksomhed og forøgede vredesudbrud, forvirring og depression, vurderet ved hjælp af 5-punkts-skalaen Profile of Mood State.
English: In a population pharmacokinetic analysis of patients with partial-onset seizures receiving Fycompa up to 12 mg/day in placebo-controlled clinical trials, Fycompa did not affect to a clinically relevant manner the clearance of clonazepam, levetiracetam, phenobarbital, phenytoin, topiramate, zonisamide, carbamazepine, clobazam, lamotrigine and valproic acid, at the highest perampanel dose evaluated (12 mg/day).
Danish: I en populationsfarmakokinetisk analyse af patienter med partielle anfald, der fik Fycompa op til 12 mg/dag i placebokontrollerede kliniske studier, påvirkede Fycompa ikke på klinisk relevant vis clearance af clonazepam, levetiracetam, phenobarbital, phenytoin, topiramat, zonisamid, carbamazepin, clobazam, lamotrigin og valproinsyre ved den højeste evaluerede perampanel-dosis (12 mg/dag).
English: Within each frequency category, adverse reactions are presented in order of decreasing seriousness.
Danish: Inden for hver enkelt gruppe over hyppigheder er bivirkningerne opstillet efter, hvor alvorlige de er.
English: Patients should be up-titrated using 2 mg doses no faster than every 2 weeks based on tolerability and effectiveness.
Danish: Patienterne bør optitreres med 2 mg doser, ikke hurtigere end hver 2. uge baseret på tolerabilitet og virkning.
English: In addition, a pharmacokinetic-pharmacodynamic (efficacy) analysis was performed in one efficacy trial for primary generalised tonic-clonic seizures.
Danish: Desuden blev en farmakokinetisk-farmakodynamisk analyse (af virkning) udført i et studie af virkning ved primært generaliserede tonisk-kloniske anfald.
English: Patients from the randomised trial were converted to perampanel over 16 weeks followed by a long term maintenance period (≥ 1 year).
Danish: Patienter fra det randomiserede studie blev skiftet til perampanel i løbet af 16 uger, efterfulgt af en langvarig vedligeholdelsesperiode (≥1 år).
English: Perampanel at a dose up to 8 mg/day has been shown to be effective in primary generalised tonic-clonic seizures.
Danish: Perampanel er ved doser på op til 8 mg/dag vist at være en virkningsfuld behandling til primært generaliserede tonisk-kloniske anfald.
English: Patients from the randomised trial were converted to perampanel over 6 weeks followed by a long term maintenance period (≥ 1 year).
Danish: Patienter fra det randomiserede studie blev skiftet til perampanel i løbet af 6 uger, efterfulgt af en langvarig vedligeholdelsesperiode (≥ 1 år).
English: Studies in animals did not indicate any teratogenic effects in rats or rabbits, but embryotoxicity was observed in rats at maternally toxic doses (see section 5.3).
Danish: Dyreforsøg indikerede ingen teratogen virkning hos rotter og kaniner, men der blev observeret embryotoksicitet hos rotter ved doser, der medførte toksicitet hos moderen (se pkt.
English: The 50% primary generalised tonic-clonic seizures responder rate during the Maintenance Period was significantly higher in the perampanel group (58.0%) than in the placebo group (35.8%), P = 0.0059.
Danish: 50 %-responsraten for primært generaliserede tonisk-kloniske anfald i løbet af vedligeholdelsesperioden var signifikant højere i perampanelgruppen (58,0 %) end i placebogruppen (35,8 %), p=0,0059.
English: The efficacy of perampanel in partial-onset seizures was established in three adjunctive therapy 19 week, randomised, double-blind, placebo-controlled, multicentre trials in adult and adolescent patients.
Danish: Perampanels virkning ved partielle anfald blev fastlagt i tre 19-ugers, randomiserede, dobbeltblinde, placebokontrollerede multicenterstudier med tillægsbehandling hos voksne og unge patienter.
English: In healthy subjects, Fycompa (6 mg once daily for 20 days) decreased midazolam AUC by 13%.
Danish: Hos raske personer reducerede Fycompa (6 mg én gang dagligt i 20 dage) AUC for midazolam med 13 %.
English: Patients should be closely monitored for tolerability and clinical response when adding or removing cytochrome P450 inducers or inhibitors, since perampanel plasma levels can be decreased or increased; the dose of perampanel may need to be adjusted accordingly.
Danish: Patienterne bør overvåges nøje for tolerabilitet og klinisk respons, når CYP-induktorer eller -hæmmere tilføjes eller fjernes, da plasmaniveauerne af perampanel kan falde eller stige.
English: The t½ was longer in mildly impaired (306 h vs. 125 h) and moderately impaired (295 h vs. 139 h) subjects compared to matched healthy subjects.
Danish: T1/2 var længere hos personer med let nedsat leverfunktion (306 t vs. 125 t) og hos personer med moderat nedsat leverfunktion (295 t vs. 139 t), sammenlignet med matchede raske personer.
English: When coadministered with a high fat meal, Cmax and AUC0-inf of a single 12-mg dose of perampanel oral suspension were approximately 22% and 13%, respectively, lower compared to fasted conditions.
Danish: Ved administration sammen med et måltid med et højt fedtindhold var Cmax og AUC0-inf for en enkelt dosis på 12 mg perampanel oral suspension hhv. ca. 22 % og 13 % lavere sammenlignet med fastende tilstande.
English: The mean change (SD) from baseline to end of double-blind treatment (19 weeks) in CDR System Global Cognition t-Score was 1.1 (7.14) in the placebo group and (minus) -1.0 (8.86) in the perampanel group, with the difference between the treatment groups in LS means (95% CI) = (minus) -2.2 (-5.2, 0.8).
Danish: Den gennemsnitlige ændring (SD) fra baseline til slutningen af den dobbeltblindede behandling (19 uger) i CDR System Global Cognition t-Score var 1,1 (7,14) i placebogruppen og (minus) -1,0 (8,86) i perampanelgruppen med en forskel mellem behandlingsgrupperne i mindste kvadraters-gennemsnit på (95 % CI) = (minus) -2,2 (-5,2; 0,8).
English: Dose adjustment is not required in patients with mild renal impairment.
Danish: Der er ikke behov for dosisjustering hos patienter med let nedsat nyrefunktion.
English: Fycompa contains lactose, therefore patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Danish: Fycompa indeholder lactose, og derfor bør det ikke anvendes til patienter med arvelig galactoseintolerans, en særlig form af hereditær lactasemangel (Lapp Lactase deficiency) eller glucose-/galactosemalabsorption.
English: Fycompa contains a medicine called perampanel.
Danish: Fycompa indeholder et stof, der kaldes perampanel.
English: Fycompa is not recommended during pregnancy.
Danish: Fycompa bør ikke anvendes under graviditeten.
English: The oral dosing syringes are graduated in 0.5 ml increments.
Danish: De orale doseringssprøjter er gradueret i 0,5 ml inddelinger.
English: - These partial seizures may or may not then be followed by a fit affecting all of your brain
Danish: - Dette partielle anfald kan måske eller måske ikke efterfølges af et anfald, der påvirker hele din hjerne (det kaldes ”sekundær generalisering”).
English: 1) Active metabolite monohydroxycarbazepine was not assessed.
Danish: Den aktive metabolit monohydroxycarbazepin blev ikke vurderet.
English: If more than 1 dose has been missed, for a continuous period of less than 5 half-lives (3 weeks for patients not taking perampanel metabolism-inducing anti-epileptic drugs (AED), 1 week for patients taking perampanel metabolism-inducing AEDs (see section 4.5)), consideration should be given to re-start treatment from the last dose level.
Danish: Hvis mere end 1 dosis glemmes i en sammenhængende periode på mindre end 5 halveringstider (3 uger for patienter, der ikke tager perampanel metabolisme-inducerende antiepileptika (AED), 1 uge for patienter, der tager perampanel metabolisme-inducerende AED'er (se pkt.
English: In vivo, perampanel significantly prolonged seizure latency in an AMPA-induced seizure model.
Danish: In vivo forlængede perampanel signifikant latens af epilepsianfald i en model af AMPA-induceret epilepsi.
English: - DRESS typically, although not exclusively, appears as flu-like symptoms and a rash with a high body temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes.
Danish: - DRESS viser sig typisk, men ikke udelukkende, som influenzalignende symptomer og udslæt ledsaget af høj kropstemperatur, forhøjede leverenzymer konstateret ved blodprøver, forhøjede niveauer af en type hvide blodlegemer (eosinofili) og forstørrede lymfeknuder.
English: Influence of AED on Fycompa concentration
Danish: AED'ers indflydelse på Fycompa-koncentrationen
English: Partial-Onset Seizures
Danish: Partielle anfald
English: - If you have missed more than 7 days of treatment with Fycompa, talk to your doctor immediately.
Danish: - Hvis du har sprunget over mere end 7 dages behandling med Fycompa, skal du straks kontakte lægen.
English: - Drinking alcohol while taking Fycompa can also make any feelings of anger, confusion or sadness worse.
Danish: - Hvis du drikker alkohol, mens du tager Fycompa, kan det også forstærke vredesudbrud, forvirring og nedtrykthed.
English: - Fycompa may make you more likely to fall over, particularly if you are an older person; this might be due to your illness.
Danish: - Fycompa kan forårsage en øget faldtendens, især hvis du er en ældre person.
English: In perampanel-treated patients in clinical trials, aggression, anger and irritability were reported more frequently at higher doses.
Danish: I kliniske studier blev aggression, vrede og irritabilitet rapporteret hyppigere hos perampanelbehandlede patienter ved højere doser.
English: Perampanel is a first-in-class selective, non-competitive antagonist of the ionotropic α-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons.
Danish: Perampanel er en first-in-class selektiv, nonkompetitiv antagonist for den inotrope α-amino-3hydroxy-5-methyl-4-isoxazol-propionsyre (AMPA)-glutamatreceptor på postsynaptiske neuroner.
English: Perampanel may cause dizziness and somnolence and, therefore, may influence the ability to drive or use machines.
Danish: Perampanel kan forårsage svimmelhed og døsighed, og derfor kan det påvirke evnen til at føre motorkøretøj eller betjene maskiner.
English: In a population pharmacokinetic analysis of the adolescent patients pooled from the Phase 2 and 3 clinical studies, there were no notable differences between this population and the overall population.
Danish: I en populationsfarmakokinetisk analyse af de unge patienter med puljede resultater fra fase 2 og 3 kliniske studier var der ingen bemærkelsesværdig forskel mellem denne population og den samlede population.
English: Aggression Anger
Danish: Aggression Vrede
English: Patients should be up-titrated using 2 mg (4 ml) doses no faster than every 2 weeks based on tolerability and effectiveness.
Danish: Patienterne bør optitreres med 2 mg (4 ml) doser, ikke hurtigere end hver 2. uge baseret på tolerabilitet og virkning.
English: For patients with mild or moderate hepatic impairment, dosing can be initiated at 2 mg.
Danish: For patienter med let eller moderat nedsat leverfunktion kan doseringen påbegyndes med 2 mg.
English: The median percent change in primary generalised tonic-clonic seizure frequency per 28 days during the Titration and Maintenance Periods (combined) relative to Prerandomisation was greater with perampanel (-76.5%) than with placebo (-38.4%), P < 0.0001.
Danish: Den mediane procentvise ændring i hyppigheden af primære generaliserede tonisk-klonisk krampeanfald pr. 28 dage i løbet af titrerings- og vedligeholdelsesperioderne (kombineret), relativt til præ-randomisering, var større med perampanel (-76,5 %) end med placebo (-38,4 %), p<0,0001.
English: Carmellose sodium (E466)
Danish: Carmellosenatrium (E466)
English: Taking Fycompa with other anti-epileptic medicine, which contains sorbitol, may affect how much they work.
Danish: Hvis du tager Fycompa sammen med andre lægemidler mod epilepsi, der indeholder sorbitol, kan det påvirke deres virkning.
English: During the 3 months maintenance period, 30.9% (25/81) of the patients on perampanel in the clinical studies became free of PGTC seizures compared with 12.3% (10/81) on placebo.
Danish: I løbet af den 3 måneder lange vedligeholdelsesperiode holdt 30,9 % (25/81) af patienterne, der fik perampanel i de kliniske studier, op med at få PGTC-krampeanfald, sammenlignet med 12,3 % (10/81) i placebogruppen.
English: In healthy subjects, the CYP3A4 inhibitor ketoconazole (400 mg once daily for 10 days) increased perampanel AUC by 20% and prolonged perampanel half--life by 15% (67.8 h vs 58.4 h).
Danish: Virkning af CYP-hæmmere på farmakokinetikken af perampanel Hos raske personer forøgede CYP3A4-hæmmeren ketoconazol (400 mg én gang dagligt i 10 dage) perampanel AUC med 20 %, og det forlængede halveringstiden af perampanel med 15 % (67,8 t vs. 58,4 t).
English: There were no effects on male fertility.
Danish: Der var ingen virkning på hannernes fertilitet.
English: Perampanel may cause dizziness and somnolence and therefore may influence the ability to drive or use machines (see section 4.7).
Danish: Perampanel kan forårsage svimmelhed og døsighed, og derfor kan det påvirke evnen til at føre motorkøretøj eller betjene maskiner (se pkt.
English: For patients with mild or moderate hepatic impairment, dosing can be initiated at 2 mg (4 ml).
Danish: For patienter med let eller moderat nedsat leverfunktion kan doseringen påbegyndes med 2 mg (4 ml).
English: Film coating (2 mg, 4 mg, 6 mg, 8 mg, 10 mg and 12 mg tablets) Hypromellose 2910, talc, Macrogol 8000, titanium dioxide (E171), colourants*
Danish: Filmovertræk (2 mg, 4 mg, 6 mg, 8 mg, 10 mg og 12 mg tabletter) Hypromellose 2910, talcum, macrogol 8000, titandioxid (E171), farvestoffer*
English: Concomitant CYP 3A inducing anti-epileptic medicinal products
Danish: Samtidige CYP3A-inducerende antiepileptika
English: 8 Leave the adaptor in place and replace cap on bottle.
Danish: Lad adapteren blive på, plads og sæt igen låget på flasken.
English: The adverse reaction most commonly leading to discontinuation (≥ 2% in the perampanel group and greater than placebo) was dizziness.
Danish: Den bivirkning, der hyppigst (≥2 % i perampanelgruppen og større end placebo) førte til seponering, var svimmelhed.
English: Fycompa is indicated for the adjunctive treatment of primary generalised tonic-clonic seizures in adult and adolescent patients from 12 years of age with idiopathic generalised epilepsy (see section 5.1).
Danish: Fycompa er indiceret som tillægsbehandling af primært generaliserede tonisk-kloniske anfald hos voksne og unge patienter fra 12 år med idiopatisk generaliseret epilepsi (se pkt.
English: Lactose monohydrate, low-substituted hydroxypropyl cellulose, povidone, magnesium stearate (E470b)
Danish: Lactosemonohydrat, lavsubstitueret hydroxypropylcellulose, povidon, magnesiumstearat (E470b)
English: Multiple dosing of perampanel 12 mg/day increased levels of anger, confusion, and depression as assessed using the Profile of Mood State 5-point rating scale (see section 5.1).
Danish: Flere doser af perampanel 12 mg/dag forøgede niveauerne af vredesudbrud, forvirring og depression, som vurderet ved 5-punkts-skalaen Profile of Mood State (se pkt.
English: In the controlled Phase 3 partial-onset seizures clinical trials, the rate of discontinuation as a result of an adverse reaction was 1.7%, 4.2% and 13.7% in patients randomised to receive perampanel at the recommended doses of 4 mg, 8 mg and 12 mg/day, respectively, and 1.4% in patients randomised to receive placebo.
Danish: I de kontrollerede fase 3 kliniske studier af partielle anfald var seponeringshyppigheden på grund af en bivirkning 1,7 %, 4,2 % og 13,7 % hos patienter, der blev randomiseret til at få perampanel med de anbefalede doser på hhv. 4 mg, 8 mg og 12 mg/dag, og 1,4 % hos patienter, der blev randomiseret til placebo.
English: 7 film-coated tablets 28 film-coated tablets 98 film-coated tablets
Danish: 7 filmovertrukne tabletter 28 filmovertrukne tabletter 98 filmovertrukne tabletter
English: What Fycompa contains - The active substance is perampanel.
Danish: Fycompa indeholder: - Aktivt stof: Perampanel.
English: Other medicines and Fycompa
Danish: Brug af anden medicin sammen med Fycompa
English: In the controlled Phase 3 primary generalised tonic-clonic seizures clinical trial, the rate of discontinuation as a result of an adverse reaction was 4.9% in patients randomised to receive perampanel 8 mg, and 1.2% in patients randomised to receive placebo.
Danish: I det kontrollerede kliniske fase 3-studie af primært generaliserede tonisk-kloniske anfald var seponeringshyppigheden som et resultat af en bivirkning 4,9 % hos patienter, der blev randomiseret til at få perampanel 8 mg, og 1,2 % hos patienter, der blev randomiseret til placebo.
English: There were no effects on male fertility (see section 5.3).
Danish: Der var ingen virkning på hannernes fertilitet (se pkt.
English: What Fycompa looks like and contents of the pack Fycompa 0.5 mg/ml oral suspension is a white to off-white suspension.
Danish: Fycompa 0,5 mg/ml oral suspension er en hvid til off-white suspension.
English: - If you have missed less than 7 days of treatment with Fycompa, continue taking your daily tablet as originally instructed by your doctor.
Danish: - Hvis du har sprunget over færre end 7 dages behandling med Fycompa, skal du fortsætte med at tage din daglige tablet, som du oprindeligt blev anvist af lægen.
English: - It is also used to treat certain fits that affect all of your brain from the start (called “generalised seizures”) and cause convulsions or staring spells.
Danish: - Det anvendes også til at behandle visse anfald, der påvirker hele din hjerne fra starten (det kaldes
English: Gait disturbance Fatigue
Danish: Gangforstyrrelser Træthed
English: Freedom from all seizures was achieved in 23.5% (19/81) of patients on perampanel compared to 4.9% (4/81) of patients on placebo.
Danish: Alle anfald holdt op hos 23,5 % (19/81) af patienterne i perampanel-gruppen sammenlignet med 4,9 % (4/81) i placebogruppen.
English: - The other ingredients are sorbitol (E420) liquid (crystallising), microcrystalline cellulose (E460), carmellose sodium (E466), poloxamer 188, simethicone emulsion 30% (containing purified water, silicone oil, polysorbate 65, methylcellulose, silica gel, macrogol stearate, sorbic acid, benzoic acid and sulfuric acid), citric acid, anhydrous (E330), sodium benzoate (E211) and purified water.
Danish: - Øvrige indholdsstoffer: Sorbitol (E420) flydende (krystalliserende), mikrokrystallinsk cellulose (E460), carmellosenatrium (E466), poloxamer 188, simeticon- emulsion 30 % (indeholdende renset vand, siliconeolie, polysorbat 65, methylcellulose, silica-gel, macrogolstearat, sorbinsyre, benzoesyre og svovlsyre), citronsyre, vandfri (E330), natriumbenzoat (E211) og renset vand.
English: 8 mg tablet: Ferric Oxide, Red (E172), Ferric Oxide, Black (E172) 10 mg tablet: Ferric Oxide, Yellow (E172), FD&C Blue #2 Indigo carmine aluminium lake (E132) 12 mg tablet: FD&C Blue #2 Indigo carmine aluminium lake (E132)
Danish: 8 mg tablet: Jernoxid, rød (E172), jernoxid, sort (E172) 10 mg tablet: Jernoxid, gul (E172), FD&C Blue #2 Indigo carmine aluminium lake (E132) 12 mg tablet: FD&C Blue #2 Indigo carmine aluminium lake (E132)
English: Simethicone emulsion 30%, containing purified water, silicone oil, polysorbate 65, methylcellulose, silica gel, macrogol stearate, sorbic acid, benzoic acid and sulfuric acid Citric acid, anhydrous (E330)
Danish: Simeticon-emulsion 30 %, indeholdende renset vand, siliconeolie, polysorbat 65, methylcellulose, silica-gel, macrogolstearat, sorbinsyre, benzoesyre og svovlsyre Citronsyre, vandfri (E330)
English: 1 bottle (340 ml) contains 170 mg perampanel.
Danish: Hver flaske (340 ml) indeholder 170 mg perampanel.
English: - If you have missed less than 7 days of treatment with Fycompa, continue taking your daily dose as originally instructed by your doctor.
Danish: - Hvis du har sprunget over færre end 7 dages behandling med Fycompa, skal du fortsætte med at tage din daglige dosis, som du oprindeligt blev anvist af lægen.
English: Fycompa 2 mg film-coated tablets Pack of 7 only for first week of dosing, 28 and 98
Danish: Fycompa 2 mg filmovertrukne tabletter Pakning med 7, kun til den første uges dosering, 28 og 98.
English: - Fycompa is not recommended in pregnancy.
Danish: - Fycompa bør ikke anvendes under graviditeten.
English: The efficacy and safety of perampanel in patients with myoclonic seizures have not been established.
Danish: Andre undertyper af idiopatisk generaliseret epilepsi Perampanels virkning og sikkerhed hos patienter med myokloniske anfald er ikke klarlagt.