FrancophonIA/ELRC3.0 huggingface dataset:
English: Haematuria, Proteinuria, Creatinine renal clearance decreased, Dysuria
Croatian: Poremećaji bubrega i mokraćnog sustava hematurija, proteinurija, snižen klirens kreatinina, dizurija akutno zatajenje bubrega kao posljedica dehidracije (rijetko)
English: Leucovorin 200 mg/m2
Croatian: 200 mg/m 2 intravenski 2
English: - If you get any side effects talk to your doctor or pharmacist.
Croatian: - Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
English: Tel: + 34 911 61 03 81
Croatian: KRKA Farmacéutica, S.L. Tel: + 34 911 61 03 81
English: Gastrointestinal disorders
Croatian: Kumarinski antikoagulansi
English: MARKETING AUTHORISATION NUMBER (S)
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: Aluminium/aluminium blisters EU/1/12/763/001 30 film-coated tablets EU/1/12/763/002 60 film-coated tablets EU/1/12/763/003 120 Film-coated tablets
Croatian: Aluminij/aluminij blisteri EU/1/12/763/001 30 filmom obloženih tableta EU/1/12/763/002 60 filmom obloženih tableta EU/1/12/763/003 120 filmom obloženih tableta
English: Faecal excretion is minimal (2.6%).
Croatian: Stolicom se izlučuje samo 2,6%.
English: Petechiae,
Croatian: Fenitoin
English: Intestinal obstruction, Ascites, Enteritis, Gastritis, Dysphagia, Abdominal pain lower, Oesophagitis, Abdominal discomfort, Gastrooesophageal reflux disease, Colitis, Blood in stool
Croatian: Poremećaji probavnog sustava proljev, povraćanje, mučnina, stomatitis, bol u abdomenu gastrointestinaln o krvarenje, konstipacija, bol u gornjem dijelu abdomena, dispepsija, flatulencija, suha usta opstrukcija rada crijeva, ascites, enteritis, gastritis, disfagija, bol u donjem dijelu abdomena, ezofagitis, nelagoda u abdomenu, gastroezofagealni refluks, kolitis, krv u stolici
English: Titanium dioxide (E171) Iron oxide red (E172) Iron oxide yellow (E172)
Croatian: Ovojnica tablete - Ecansya 150 mg filmom obložene tablete hipromeloza (6cps) talk titanijev dioksid (E171) željezov oksid, crveni (E172) željezov oksid, žuti (E172)
English: Sore throat, Dysaesthesia pharynx
Croatian: Österreich KRKA Pharma GmbH, Wien
English: Skin toxicity, characterised by degenerative/regressive changes, was observed with capecitabine.
Croatian: Primijećeno je da kapecitabin može izazvati i kožnu toksičnost koja se manifestirala promjenama degenerativnoregresivne naravi.
English: Sequential treatment consisted of first-line capecitabine (1250 mg/m2 twice daily for 14 days), second-line irinotecan (350 mg/m2 on day
Croatian: Sekvencijska terapija sastojala se od primjene kapecitabina (1250 mg/m2 dvaput dnevno tijekom 14 dana) u prvoj liniji liječenja, primjene irinotekana (350 mg/m 1. dana) u drugoj liniji te, na kraju, liječenja kombinacijom kapecitabina (1000 mg/m2 dvaput dnevno tijekom 14 dana) i oksaliplatina (130 mg/m 2 1. dana) u trećoj liniji liječenja.
English: Each film-coated tablet contains 15 mg anhydrous lactose.
Croatian: Jedna filmom obložena tableta sadrži 150 mg kapecitabina.
English: Jaundice
Croatian: KRKA
English: Hiccups, Pharyngolaryngeal pain, Dysphonia
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja grlobolja, dizestezija ždrijela štucavica, faringolaringealna bol, disfonija
English: Skin and subcutaneous tissue disorders
Croatian: Poremećaji uha i labirinta tinitus, oslabljen sluh
English: KRKA Farmaceutici Milano S.r.l.
Croatian: KRKA Pharma Dublin, Ltd.
English: Ear and labyrinth disorders
Croatian: INR/produljeno protrombinsko vrijeme
English: In these trials, a total of 236 patients were treated with capecitabine (1250 mg/m2 twice daily for 2 weeks followed by 1-week rest period).
Croatian: U tim je ispitivanjima kapecitabinom (1250 mg/m2 dvaput dnevno tijekom 2 tjedna, nakon čega je slijedila jednotjedna pauza) liječeno 236 bolesnika.
English: -2nd appearance -3rd appearance
Croatian: 17. JEDINSTVENI IDENTIFIKATOR - 2D BARKOD
English: Talc
Croatian: Lot
English: -2nd appearance
Croatian: PRILOG II.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 500 mg capecitabine.
Croatian: Jedna filmom obložena tableta sadrži 500 mg kapecitabina.
English: Pharyngitis, Oral candidiasis, Influenza, Gastroenteritis, Fungal infection, Infection, Tooth abscess
Croatian: Infekcije i infestacije infekcija herpes virusom, nazofaringitis, infekcija donjeg dišnog sustava sepsa, infekcija mokraćnog sustava, celulitis, tonzilitis, upala ždrijela, oralna kandidijaza, gripa, gastroenteritis, gljivična infekcija, infekcija, apsces zuba
English: Dose level 1250 mg/m2 (twice daily)
Croatian: 5 tableta od 500 mg dvaput dnevno.
English: Joint swelling, Bone pain, Facial pain, Musculoskeletal stiffness, Muscular weakness
Croatian: Poremećaji mišićnokoštanog sustava i vezivnog tkiva mialgija, artralgija, bol u ekstremitetima bol u čeljusti, spazmi mišića, trizmus, slabost mišića
English: Monotherapy
Croatian: Alopurinol
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 300 mg capecitabine.
Croatian: Jedna filmom obložena tableta sadrži 300 mg kapecitabina.
English: Ecansya 500 mg tablets capecitabine
Croatian: Ecansya 500 mg filmom obložene tablete kapecitabin
English: Discontinue permanently
Croatian: Manje često
English: PHARMACEUTICAL FORM
Croatian: FARMACEUTSKI
English: Ελλάδα
Croatian: Vrlo često
English: NAME OF THE MEDICINAL PRODUCT Ecansya 150 mg film-coated tablets capecitabine
Croatian: Ecansya 150 mg filmom obložene tablete kapecitabin
English: NAME OF THE MEDICINAL PRODUCT Ecansya 150 mg film-coated tablets multilingual blister:
Croatian: Ecansya 150 mg filmom obložene tablete multijezični blisteri: Ecansya 150 mg tablete kapecitabin
English: EU/1/13/848/001 Erivedge
Croatian: EU/1/13/848/001
English: 28 capsules
Croatian: 28 kapsula
English: Immediate Packaging
Croatian: Veličina pakovanja
English: MA (EU) Number (Invented) name Strength Pharmaceutical Form Route of Administration
Croatian: Broj (EU) odobrenja (Zaštićeno) ime
English: Oral use bottle (HDPE)
Croatian: Erivedge 150 mg tvrde kapsule kroz usta bočica (HDPE)
English: PC: {number} SN: {number} NN: {number}
Croatian: PC: {broj} SN: {broj} NN: {broj}
English: • At the request of the European Medicines Agency;
Croatian: Na zahtjev Europske agencije za lijekove;
English: Take the capsules on an empty stomach; for example, at least one hour before you plan to eat breakfast.
Croatian: Kapsule uzmite na prazan želudac; primjerice najmanje sat vremena prije nego što planirate doručkovati.
English: • if you are older than 70 years of age.
Croatian: ako imate više od 70 godina.
English: Elderly patients (> 70 years of age)
Croatian: Stariji bolesnici (> 70 godina)
English: After Day 28, the next cycle will begin.
Croatian: Nakon 28. dana započinje sljedeći ciklus.
English: - This medicine has been prescribed for you only.
Croatian: Ovaj je lijek propisan samo Vama.
English: Errors in how you take this medicine may have serious health consequences.
Croatian: Pogreške u načinu uzimanja ovog lijeka mogu imati ozbiljne posljedice za zdravlje.
English: • if you have ever had or might now have a hepatitis B infection.
Croatian: ako ste ikada imali ili možda sada imate infekciju hepatitisom B.
English: SL-1526 Ljubljana Slovenia
Croatian: SL-1526 Ljubljana Slovenija
English: However, no unacceptable risks appear to be present in this patient group.
Croatian: Ipak, u ovoj skupini bolesnika nema neprihvatljivih rizika.
English: Capsules should not be opened.
Croatian: Kapsule se ne smiju otvarati.
English: In 43 patients stable disease was reported.
Croatian: U 43 pacijenta prijavljena je stabilna bolest.
English: You may also need other treatments.
Croatian: Možda će Vam biti potrebna i druga terapija.
English: This leaflet was last revised in <{MM/YYYY}>.
Croatian: Ova uputa je zadnji puta revidirana u <{MM/GGGG}>.
English: Ask your doctor or pharmacist to write it down (including the colour).
Croatian: Zamolite svog liječnika ili ljekarnika da Vam to zapiše (uključujući boju).
English: Supportive measures should be provided as necessary.
Croatian: Po potrebi treba uvesti potporne mjere.
English: Once the radiotherapy is completed, you will interrupt treatment for 4 weeks.
Croatian: Nakon završetka terapije zračenjem, prekinut ćete liječenje na 4 tjedna.
English: • Risk Management Plan (RMP)
Croatian: LIJEKA Plan upravljanja rizikom (RMP)
English: This will give your body a chance to recover.
Croatian: Tako će se Vaše tijelo moći oporaviti.
English: Although the data is limited, tolerance in children is expected to be the same as in adults.
Croatian: Iako su podaci ograničeni očekuje se slična podnošljivost u djece kao i u odraslih.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: {DD/MM/YYYY}
Croatian: {DD/MM/GGGG}
English: The reduction in blood cell counts is usually short-lived.
Croatian: Smanjenje broja krvnih stanica obično je kratkotrajno.
English: The median PFS was 5.4 months.
Croatian: Medijan PFS-a bio je 5,4 mjeseca.
English: Do not take a double dose to make up for a forgotten dose, unless your doctor tells you to do so.
Croatian: Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljenu dozu, osim ako Vam to nije rekao liječnik.
English: An updated RMP should be submitted:
Croatian: Nadalje, nadopunjeni RMP treba dostaviti:
English: During treatment a complete blood count should be obtained weekly.
Croatian: Tijekom liječenja se svakog tjedna mora napraviti kompletna krvna slika.
English: Date of first authorisation: 15 March 2010 Date of latest renewal: 19 November 2014
Croatian: Datum posljednje obnove: 19. studenoga 2014
English: This latency period is very short even for an alkylating agent.
Croatian: Ovaj period latencije vrlo je kratak čak i za alkilirajuću tvar.
English: In this case, your doctor will also prescribe medicine to help you prevent this type of pneumonia (PCP).
Croatian: U tom slučaju liječnik će Vam propisati i lijekove za sprečavanje ove vrste upale pluća (PCP).
English: The capsules must be swallowed whole with a glass of water and must not be opened or chewed.
Croatian: Kapsule se moraju progutati cijele uz čašu vode i ne smiju se otvarati niti žvakati.
English: TMZ can have genotoxic effects.
Croatian: TMZ može imati genotoksične učinke.
English: In this case, do not drive or use any tools or machines or cycle until you see how this medicine affects you (see section 4).
Croatian: U tom slučaju nemojte voziti niti rukovati alatima ili strojevima ili voziti bicikl dok ne vidite kako ovaj lijek djeluje na Vas (vidjeti dio 4).
English: Tell your pharmacist if you notice any change in the appearance of the capsules.
Croatian: Obavijestite svog ljekarnika ako primijetite bilo kakvu promjenu izgleda kapsula.
English: 1 capsule
Croatian: 1 kapsula
English: Achieving a radiological objective response or maintaining progression-free status was strongly associated with maintained or improved quality of life.
Croatian: Postizanje radiološki objektivnog odgovora ili održavanje statusa bez progresije bolesti čvrsto je povezano s održanom ili poboljšanom kvalitetom života.
English: Take the missed dose as soon as possible during the same day.
Croatian: Uzmite propuštenu dozu što je prije moguće tijekom istog dana.
English: Do not swallow it.
Croatian: Nemojte je progutati.
English: Keep the bottles tightly closed in order to protect from moisture.
Croatian: Bočice čuvati čvrsto zatvorene radi zaštite od vlage.
English: Median overall survival was 14.6 months.
Croatian: Medijan ukupnog preživljenja iznosio je 14,6 mjeseci.
English: Other sources of information
Croatian: Drugi izvori informacija
English: V J Salomone Pharma Limited Upper Cross Road, Marsa MRS 1542
Croatian: J Salomone Pharma Limited Upper Cross Road, Marsa MRS 1542
English: See footnote b
Croatian: Vidjeti bilješku b
English: For any information about this medicinal product, please contact the local representative of the Marketing Authorisation Holder:
Croatian: Za sve informacije o ovom lijeku obratite se lokalnom predstavniku nositelja odobrenja za stavljanje lijeka u promet:
English: The incidence of severe nausea and vomiting was 4 %.
Croatian: Incidencija teške mučnine i povraćanja iznosila je 4 %.
English: Dosage and duration of treatment
Croatian: Doza i trajanje liječenja
English: As it cannot be excluded that the change in Cmax is clinically significant, Temozolomide Sandoz should be administered without food.
Croatian: Budući da se ne može isključiti da je promjena Cmax klinički značajna, Temozolomid Sandoz treba uzimati bez hrane.
English: During treatment patients should be monitored and managed appropriately.
Croatian: Tijekom liječenja, bolesnika je potrebno pratiti i tretirati na odgovarajući način.
English: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Croatian: Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: This daily dose depends on whether or not you have received chemotherapy before.
Croatian: Ova dnevna doza ovisi o tome jeste li ranije već primali kemoterapiju.
English: Frequency groupings are defined according to the following convention:
Croatian: Učestalost pojavljivanja razvrstana je prema sljedećoj konvenciji:
English: There are no data in pregnant women.
Croatian: Nema podataka o primjeni u trudnica.
English: • dose level -1 (100 mg/m2) still results in unacceptable toxicity
Croatian: • ako razina doze -1 (100 mg/m2) i dalje proizvodi neprihvatljive toksične učinke
English: • which days are your dosing days.
Croatian: koji dani su Vaši dani za uzimanje lijeka.
English: Then, you will start the monotherapy phase.
Croatian: Potom ćete započeti fazu monoterapije.
English: Patients will be carefully checked by their doctor for signs of this infection before treatment is started.
Croatian: Liječnik će pažljivo pregledati bolesnike za znakove ove infekcije prije početka liječenja.
English: Always take Temozolomide Sandoz exactly as your doctor has told you.
Croatian: Uvijek uzmite Temozolomid Sandoz točno onako kako Vam je rekao Vaš liječnik.
English: Paediatric population Interaction studies have only been performed in adults.
Croatian: Ispitivanja interakcija provedena su samo u odraslih.
English: Hard capsule (capsule).
Croatian: Tvrda kapsula (kapsula).
English: Liver toxicity may occur several weeks or more after the last treatment with temozolomide.
Croatian: Toksičnost jetre može nastupiti nekoliko tjedana ili više nakon zadnje primjene temozolomida.
English: Depending on the prescribed dose, you may have to take more than one capsule together, eventually with different strengths (content of active substance, in mg).
Croatian: Ovisno o propisanoj dozi, možda ćete morati zajedno uzimati više od jedne kapsule, koje mogu biti različite jačine (sadrže različitu količinu djelatne tvari u miligramima).
English: Excipient with known effect:
Croatian: Pomoćna tvar s poznatim učinkom:
English: This is because you must not be treated with Temozolomide Sandoz during pregnancy unless clearly indicated by your doctor.
Croatian: To je zbog toga što se ne smijete liječiti Temozolomidom Sandoz tijekom trudnoće, osim ako ga Vaš liječnik nije izričito propisao.
English: TMZ + concomitant RT n=288*
Croatian: TMZ + istodobna RT n = 288*
English: Each one lasts 28 days.
Croatian: Svaki ciklus traje 28 dana.
English: No evidence of cumulative myelosuppression was observed.
Croatian: Nije bilo dokaza kumulativne mijelosupresije.
English: In the event of an overdose, haematological evaluation is needed.
Croatian: U slučaju predoziranja potrebna je procjena hematološkog statusa.
English: It is very important to check with your doctor or pharmacist if you are not sure.
Croatian: Vrlo je važno da provjerite sa svojim liječnikom ili ljekarnikom ako niste sigurni.
English: Experience in these children is very limited (see sections 4.4 and 5.1).
Croatian: Iskustvo u ove djece vrlo je ograničeno (vidjeti dijelove 4.4 i 5.1).
English: Figure 1 Kaplan-Meier curves for overall survival (intent-to-treat population)
Croatian: Slika 1 Kaplan-Meierove krivulje ukupnog preživljenja (populacija koju se namjeravalo liječiti)
English: Laboratory parameters
Croatian: Laboratorijski parametri
English: These blood cells are important for fighting infection and for proper blood clotting.
Croatian: Te su krvne stanice važne za obranu od infekcija te za pravilno zgrušavanje krvi.
English: Experts in liver disease should be consulted before treatment is initiated in patients with positive hepatitis B serology (including those with active disease).
Croatian: Potrebno je konzultirati se sa stručnjacima za bolesti jetre prije početka liječenja bolesnika s pozitivnom serologijom na hepatitis B (uključujući i one s aktivnom bolesti).
English: However, because the doses implicated in retinal degeneration were in the lethal dose range, and no comparable effect has been observed in clinical studies, this finding was not considered to have clinical relevance.
Croatian: Međutim s obzirom da su doze koje su izazvale degeneraciju mrežnice bile u rasponu letalnih doza, a sličan učinak nije opažen u kliničkim ispitivanjima, ovaj se nalaz ne smatra klinički značajnim.
English: If Temozolomid Sandoz comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Croatian: Ako Temozolomid Sandoz dođe u kontakt s kožom ili sluznicom, to područje treba odmah temeljito isprati sapunom i vodom.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Croatian: Od zdravstvenih djelatnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava navedenog u Dodatku V.
English: † Including cases with fatal outcome * Frequencies estimated based on relevant clinical trials.
Croatian: † uključujući slučajeve sa smrtnim ishodom *učestalost procijenjena na temelju relevantnih kliničkih ispitivanja.
English: Hallucination, amnesia
Croatian: Halucinacije, amnezija
English: Swallow the capsule(s) whole with a glass of water.
Croatian: Kapsule progutajte cijele, s čašom vode.
English: No studies have been conducted to determine the effect of TMZ on the metabolism or elimination of other medicinal products.
Croatian: Nisu provedena ispitivanja kojima bi se odredio učinak TMZ-a na metabolizam ili eliminaciju drugih lijekova.
English: Do not open, crush or chew the capsules.
Croatian: Nemojte otvarati, drobiti niti žvakati kapsule.
English: In very rare cases, patients taking temozolomide and medicines like it may have a small risk of developing secondary cancers, including leukaemia.
Croatian: U vrlo rijetkim slučajevima, bolesnici koji uzimaju temozolomid i slične lijekove mogu imati malen rizik od razvoja sekundarnih vrsta raka, uključujući leukemiju.
English: In some cases, it may be prolonged and may lead to a very severe form of anaemia (aplastic anaemia).
Croatian: U nekim slučajevima može biti dugotrajno te dovesti do vrlo teškog oblika anemije (aplastične anemije).
English: • high blood pressure
Croatian: 20. visok krvni tlak
English: • The other ingredients of the capsule are
Croatian: Drugi sastojci kapsule su
English: TMZ is more toxic to the rat and dog than to humans, and the clinical dose approximates the minimum lethal dose in rats and dogs.
Croatian: TMZ je toksičniji za štakore i pse nego za čovjeka, a klinička je doza blizu najniže letalne doze za štakore i pse.
English: Contains lactose.
Croatian: Sadrži laktozu.
English: CTC Grade 4b a: TMZ dose levels are listed in Table 2. b: TMZ is to be discontinued if:
Croatian: CTC stupanj 4b a: razine doza TMZ-a navedene su u Tablici 2. b: TMZ se mora prekinuti:
English: Experience in older children and adolescents is very limited (see sections 4.2 and 5.1).
Croatian: Iskustvo u starije djece i adolescenata vrlo je ograničeno (vidjeti dijelove 4.2 i 5.1).
English: Your doctor will monitor your blood regularly for any changes, and will decide if any specific treatment is needed.
Croatian: Liječnik će Vam redovito kontrolirati krvnu sliku kako bi uočio eventualne promjene i odlučiti je li potrebno specifično liječenje.
English: If a full day has gone by, check with your doctor.
Croatian: Ako je prošao cijeli dan, provjerite s Vašim liječnikom što trebate učiniti.
English: Administration of TMZ with food resulted in a 33 % decrease in Cmax and a 9 % decrease in area under the curve (AUC).
Croatian: Primjena TMZ-a s hranom dovela je do smanjenja Cmax za 33 %, a površine ispod krivulje (AUC) za 9 %.
English: • if you develop fever or symptoms of an infection, contact your doctor immediately.
Croatian: ako dobijete vrućicu ili simptome infekcije, odmah se javite svom liječniku.
English: TMZ monotherapy n=224
Croatian: TMZ u monoterapiji n = 224
English: ANNEX II
Croatian: DODATAK III
English: Rats appear to be particularly sensitive to oncogenic effects of TMZ, with the occurrence of first tumours within 3 months of initiating dosing.
Croatian: Štakori se doimaju osobito osjetljivima na onkogene učinke TMZ-a, a prvi tumori se pojavljuju u roku od 3 mjeseca nakon početne doze.
English: Salutas Pharma GmbH Otto-von-Guericke-Allee 1 D-39179 Barleben Germany
Croatian: Salutas Pharma GmbH Otto-von-Guericke-Allee 1 D-39179 Barleben
English: If you vomit frequently before or during treatment, ask your doctor about the best time to take Temozolomide Sandoz until the vomiting is under control.
Croatian: Ako često povraćate prije ili za vrijeme liječenja, upitajte svog liječnika u koje je vrijeme najbolje uzimati Temozolomid Sandoz sve dok povraćanje ne bude pod kontrolom.
English: If you accidentally get some in your eyes or nose, flush the area with water.
Croatian: Ako prah slučajno dospije u oči ili nos, isperite ih vodom.
English: Pneumocystis jirovecii pneumonia
Croatian: Pneumocystis jirovecii pneumoniju
English: For the eligible histology population, the efficacy results were similar.
Croatian: U skupini bolesnika koja je zadovoljavala histološke kriterije rezultati djelotvornosti bili su slični.
English: The carton contains one bottle.
Croatian: Pakiranje sadrži jednu bočicu.
English: Sandoz GmbH Biochemiestraße 10 A-6250 Kundl Austria
Croatian: Sandoz GmbH Biochemiestraße 10 A-6250 Kundl Austrija
English: toxic epidermal necrolysis, Stevens-Johnson syndrome
Croatian: toksična epidermalna nekroliza, Stevens-Johnsonov sindrom
English: It is recommended to seek advice on conservation of sperm prior to treatment.
Croatian: Preporučuje se da potraže savjet kako pohraniti spermu prije početka liječenja.
English: Plasma concentrations increase in a dose-related manner.
Croatian: Koncentracije u plazmi povećavaju se sukladno dozi.
English: This may cause you to have increased bruising or bleeding, anaemia (a shortage of red blood cells), fever, and reduced resistance to infections.
Croatian: To može uzrokovati povećanu sklonost modricama ili krvarenju, anemiju (nedostatak crvenih krvnih stanica), vrućicu i smanjenu otpornost na infekcije.
English: The lowest recommended dose is 100 mg/m2.
Croatian: Najniža preporučena doza iznosi 100 mg/m2.
English: • increased skin sensitivity to sunlight
Croatian: 29. povećana osjetljivost kože na sunčevu svjetlost
English: You might be more prone to infections, bruising or bleeding.
Croatian: Možete biti skloniji infekcijama, stvaranju modrica ili krvarenju.
English: Dose-limiting toxicity was haematological and was reported with any dose but is expected to be more severe at higher doses.
Croatian: Toksični učinci koji su ograničavali dozu bili su hematološki i prijavljeni su za svaku dozu, no očekuje se da će biti jači pri višim dozama.
English: Most of the toxicity showed evidence of reversibility, except for adverse events on the male reproductive system and retinal degeneration.
Croatian: Veći dio toksičnih učinaka bio je reverzibilan, osim štetnih učinaka na reproduktivni sustav mužjaka i degeneracije mrežnice.