FrancophonIA/ELRC3.0 huggingface dataset:
English: If you have any questions, please talk to your doctor or pharmacist before you take this medicine.
Slovenian: Če imate kakršna koli vprašanja, se pred začetkom jemanja tega zdravila posvetujte z zdravnikom ali farmacevtom.
English: Methotrexate causes embryotoxicity, abortion and foetal malformations in humans.
Slovenian: Metotreksat povzroča pri ljudeh embriotoksičnost, splav in okvare ploda.
English: Psoriasis skin changes can become worse during treatment with methotrexate if you are under UV light.
Slovenian: Kožne spremembe, ki jih povzroča luskavica, se lahko med zdravljenjem z metotreksatom poslabšajo, če ste izpostavljeni ultravijolični svetlobi.
English: For higher doses, there is insufficient data to estimate the risks of malformations or miscarriage following paternal exposure.
Slovenian: Ni dovolj podatkov za oceno tveganja za malformacije ali splav po izpostavljenosti očeta večjim odmerkom.
English: If you suspect you have a severe side effect, talk to your doctor immediately.
Slovenian: Če sumite, da so se pojavili hudi neželeni učinki, se nemudoma posvetujte z zdravnikom.
English: Wash the syringe immediately after use with fresh warm, soapy water and rinse well.
Slovenian: Takoj po uporabi sperite brizgo s čisto, toplo milnico in jo dobro splaknite.
English: The recommended dose is 10-15 mg (5-7.5 ml)/m² body surface area (BSA)/week.
Slovenian: Priporočeni odmerek je 10-15 mg (5-7,5 ml)/m² telesne površine tedensko.
English: There is a pronounced enterohepatic circulation.
Slovenian: Enterohepatični obtok je močno izražen.
English: − impaired movement of the muscles used for speech production, difficulty in speaking, impairment of language, feeling sleepy or tired, feeling confused, having unusual sensations in the head, brain swelling, ringing in ears
Slovenian: − prizadeto gibanje mišic za govor, težave z govorom, slabše govorno izražanje, občutek zaspanosti ali utrujenosti, občutek zmedenosti, nenavadni občutki v glavi, otekanje možganov,
English: Therefore, methotrexate should only be administered by, or under the supervision of, doctors whose knowledge and experience includes treatment with antimetabolites.
Slovenian: Zato sme zdravljenje z metotreksatom uvesti in nadzorovati samo zdravnik, ki je usposobljen in izkušen v zdravljenju z antimetaboliti.
English: Co-administration of proton pump inhibitors such as omeprazole or pantoprazole can result in interactions: co-administration of methotrexate and omeprazole has resulted in delayed renal elimination of methotrexate.
Slovenian: Sočasna uporaba zaviralcev protonske črpalke, kot sta omeprazol ali pantoprazol, lahko vodi do medsebojnega delovanja: sočasno jemanje metotreksata in omeprazola je povzročilo zakasnjeno ledvično izločanje metotreksata.
English: Because of the delayed excretion of methotrexate in patients with impaired kidney function, they should be treated with particular caution and only with low doses of methotrexate (see section 4.2).
Slovenian: Bolnike z okvarjenim delovanjem ledvic je treba zaradi zakasnelega izločanja metotreksata zdraviti posebno skrbno in samo z majhnimi odmerki metotreksata (glejte poglavje 4.2).
English: Patients should be instructed on the importance of adhering to the once-weekly intakes.
Slovenian: Bolnikom je treba pojasniti, kako pomembno se je držati jemanja enkrat tedensko.
English: The consumption of alcohol should be avoided during treatment with methotrexate (see section 4.4).
Slovenian: Med zdravljenjem z metotreksatom se je treba izogibati uživanju alkohola (glejte poglavje 4.4).
English: 60 ml
Slovenian: peroralna raztopina 60 ml
English: Summary of the safety profile In general, the incidence and severity of side effects are considered to be dose-related.
Slovenian: V splošnem velja, da sta pojavnost in stopnja resnosti neželenih učinkov povezana z odmerkom.
English: − breathing problems (these include a general feeling of illness, dry, irritating cough, shortness of breath, difficulty in breathing, chest pain or fever)
Slovenian: − težave z dihanjem (te vključujejo splošno slabo počutje, suh, dražeč kašelj, zadihanost, oteženo dihanje, bolečine v prsih ali zvišano telesno temperaturo),
English: Combined administration of mercaptopurine and methotrexate can increase the bioavailability of mercaptopurine, possibly as a result of inhibition of the metabolism of mercaptopurine.
Slovenian: Pri sočasni uporabi merkaptopurina in metotreksata se lahko poveča biološka uporabnost merkaptopurina, verjetno zaradi zaviranja presnove merkaptopurina.
English: Overdose could lead to serious adverse effects and may be fatal.
Slovenian: Preveliko odmerjanje lahko povzroči resne neželene učinke in lahko vodi do smrti.
English: − spitting or coughing blood*
Slovenian: − pljuvanje ali izkašljevanje krvi*,
English: Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2).
Slovenian: Predpisovanje in izdaja zdravila je le na recept (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
English: For arthritis and psoriasis take only once a week.
Slovenian: Pri zdravljenju artritisa in psoriaze vzemite odmerek samo enkrat na teden.
English: Methotrexate has been shown to be teratogenic to humans; it has been reported to cause foetal death, miscarriages and/or congenital abnormalities (e.g. craniofacial, cardiovascular, central nervous system and extremity-related).
Slovenian: Ugotovljeno je teratogeno delovanje metotreksata pri ljudeh: poročali so o smrtih ploda, splavih in/ali prirojenih nepravilnostih, npr. lobanje in obraza, srčno-žilnega sistema,
English: Contents of the pack and other information
Slovenian: Shranjevanje zdravila Jylamvo Vsebina pakiranja in dodatne informacije
English: If risk factors such as renal function disorders, including mild renal impairment, are present, combined administration with NSAIDs is not recommended.
Slovenian: Pri dejavnikih tveganja, kot so motnje delovanja ledvic, vključno z blago ledvično okvaro, sočasna uporaba nesteroidnih protivnetnih zdravil (NSAID) ni priporočljiva.
English: Jylamvo is used in patients with: - the following rheumatic and skin diseases: o active rheumatoid arthritis (RA) in adults o polyarthritic forms (when five or more joints are affected) of active, severe juvenile idiopathic arthritis (JIA) in adolescents and children aged 3 years and over when the response to non-steroidal anti-inflammatory drugs (NSAIDs) has been inadequate o severe, treatment-resistant, disabling psoriasis that does not respond sufficiently to other forms of treatment such as phototherapy, psoralen and ultraviolet A radiation (PUVA) therapy and retinoids, as well as in severe psoriasis that also affects the joints (psoriatic arthritis) in adult patients - acute lymphoblastic leukaemia (ALL) in adults, adolescents and children aged 3 years and over
Slovenian: o poliartikularnimi oblikami (pri katerih je prizadetih pet ali več sklepov) aktivnega, hudega juvenilnega idiopatičnega artritisa (JIA) pri mladostnikih in otrocih, starih tri leta in več, ki se nezadostno odzivajo na nesteroidna protivnetna zdravila (NSAID); o hudo in na zdravljenje odporno luskavico, ki povzroča invalidnost in se ne odziva ustrezno na druge oblike zdravljenja, kot so fototerapija, psoraleni in obsevanje z ultravijolično svetlobo A (PUVA) in retinoidi, ter hudim psoriatičnim artritisom pri odraslih, ki prizadene tudi sklepe (psoriatičnim artritisom);
English: See section 2 “Jylamvo contains ethyl parahydroxybenzoate and sodium methyl parahydroxybenzoate”.
Slovenian: Glejte poglavje 2 „Zdravilo Jylamvo vsebuje etilparahidroksibenzoat in natrijev metilparahidroksibenzoat“.
English: Increase in liver-related enzymes (ALAT [GPT], ASAT [GOT], alkaline phosphatase and bilirubin)
Slovenian: žolčnika in žolčevodov zvišane vrednosti jetrnih encimov (ALAT [GPT], ASAT [GOT], alkalne fosfataze in bilirubina)
English: Nervous system disorders
Slovenian: osrednjega živčnega sistema in okončin.
English: The oral solution contains 2 mg of methotrexate in each ml of solution; the scaling of the dosing syringe is in ml and not mg; care should be taken that the correct dosing volume is prescribed.
Slovenian: 4.4 Posebna opozorila in previdnostni ukrepi Peroralna raztopina vsebuje 2 mg metotreksata v vsakem mililitru raztopine; merilne enote na brizgi za odmerjanje so mililitri in ne miligrami; paziti je treba, da je predpisan pravilni volumen odmerjanja.
English: • Maintenance treatment of acute lymphoblastic leukaemia (ALL) in adults, adolescents and children aged 3 years and over
Slovenian: − akutno limfoblastno levkemijo (ALL) pri odraslih, mladostnikih in otrocih, starih tri leta in več.
English: Pharmacokinetic interactions between methotrexate, anticonvulsants (reduced serum methotrexate levels) and 5-fluoruracil (increased half-life of 5-fluoruracil) must be borne in mind.
Slovenian: (znižujejo serumske koncentracije metotreksata) in 5-fluorouracilom (podaljša se razpolovni čas 5-fluorouracila).
English: − yellow colouring of the skin (jaundice) or dark urine
Slovenian: − porumenelost kože (zlatenica) ali temen urin,
English: IF YOU USE METHOTREXATE FOR ONE OF THE ABOVE MENTIONED INDICATIONS, YOU SHOULD ONLY TAKE METHOTREXATE ONCE A WEEK
Slovenian: ČE UPORABLJATE METOTREKSAT ZA ENO OD ZGORAJ NAVEDENIH INDIKACIJ,
English: Patients taking potentially hepatotoxic medicinal products during treatment with methotrexate (e.g. leflunomide, azathioprine, sulfasalazine and retinoids) should be monitored closely for increased hepatotoxicity.
Slovenian: Bolnike, ki med zdravljenjem z metotreksatom sočasno jemljejo druga morebitna hepatotoksična zdravila (npr. leflunomid, azatioprin, sulfasalazin in retinoide), je treba skrbno spremljati zaradi morebitnega povečanja hepatotoksičnosti.
English: Dosage in acute lymphoblastic leukaemia
Slovenian: Onkologija Odmerek pri akutni limfoblastni levkemiji
English: This medicinal product contains sodium methyl parahydroxybenzoate (E219) and ethyl parahydroxybenzoate (E214).
Slovenian: To zdravilo vsebuje natrijev metilparahidroksibenzoat (E219) in etilparahidroksibenzoat (E214).
English: If creatinine clearance is less than 30 ml/min, treatment with methotrexate should not be given (see sections 4.2 and 4.3).
Slovenian: Zdravljenje z metotreksatom se ne sme uvesti, če je kreatininski očistek manjši od 30 ml/min (glejte poglavji 4.2 in 4.3).
English: Dosage errors in the use of Jylamvo (methotrexate) can result in serious adverse reactions, including death.
Slovenian: Nepravilno odmerjanje zdravila Jylamvo (metotreksat) lahko povzroči resne neželene učinke, vključno s smrtjo.
English: Taking Jylamvo incorrectly can result in severe side effects and even death.
Slovenian: Nepravilno jemanje zdravila Jylamvo lahko povzroči hude neželene učinke in celo smrt.
English: Alkalinisation of the urine must be tested by repeated pH monitoring (value greater than or equal to 6.8) for at least the first 24 hours after the administration of methotrexate is started.
Slovenian: Vsaj prvih 24 ur po začetku dajanja metotreksata je treba testirati alkalinizacijo urina s ponavljajočim se nadzorom vrednosti pH (vrednosti, večje ali enake 6,8).
English: Conversely, co-administration of medicinal products containing folinic acid or vitamin preparations containing folic acid or derivatives may impair the efficacy of methotrexate.
Slovenian: Po drugi strani pa lahko sočasna uporaba zdravil s folinsko kislino ali vitaminskih pripravkov s folno kislino oziroma njenimi derivati zmanjša učinkovitost metotreksata.
English: − bone fractures
Slovenian: − zlomi kosti,
English: For arthritis and psoriasis take only once a week on ………….
Slovenian: Pri zdravljenju artritisa in psoriaze vzemite odmerek samo enkrat na teden, in sicer v:………….
English: The syringe should be held under water and the plunger drawn in and out several times until all traces of medicine are removed from inside the syringe including the tip.
Slovenian: Brizgo morate držati pod vodo in bat vleči in potiskati navznoter toliko časa, dokler v notranjosti brizge, vključno s konico, ni več sledi zdravila.
English: Regular alcohol consumption and administration of additional hepatotoxic medicinal products increase the likelihood of hepatotoxic adverse reactions to methotrexate.
Slovenian: Redno uživanje alkohola in sočasna uporaba drugih hepatotoksičnih zdravil povečata tveganje za neželene hepatotoksične učinke zaradi metotreksata.
English: In patients with rheumatoid arthritis or psoriasis, folic acid or folinic acid supplementation may reduce methotrexate toxicity, such as gastrointestinal symptoms, stomatitis, alopecia and elevated liver enzymes.
Slovenian: Pri bolnikih z revmatoidnim artritisom ali psoriazo se lahko z dodajanjem folne ali folinske kisline zmanjšajo toksični učinki metotreksata, kot so gastrointestinalni simptomi, vnetje ustne sluznice, izpadanje las in zvišane vrednosti jetrnih encimov.
English: − nettle rash, skin reaction in strong light, brown discoloration of the skin, hair loss, increased number of rheumatic nodules, shingles, painful psoriasis, slow wound healing
Slovenian: − koprivnica, reakcija kože na močno svetlobo, porjavelost kože, izpadanje las, povečanje števila revmatičnih vozličev, pasovec, boleča luskavica, počasno celjenje ran,
English: Methotrexate is a folic acid antagonist that, as an antimetabolite, belongs to the class of cytotoxic active substances.
Slovenian: Metotreksat je antagonist folne kisline, ki spada v razred citotoksičnih zdravilnih učinkovin.
English: Most serious adverse reactions of methotrexate include bone marrow suppression, pulmonary toxicity, hepatotoxicity, renal toxicity, neurotoxicity, thromboembolic events, anaphylactic shock and StevensJohnson syndrome.
Slovenian: Najresnejši neželeni učinki metotreksata vključujejo zaviranje delovanja kostnega mozga, toksičnost za pljuča, hepatotoksičnost, toksičnost za ledvice, nevrotoksičnost, trombembolične dogodke, anafilaktični šok in Stevens-Johnsonov sindrom.
English: This applies in particular when medicinal products that affect the elimination of methotrexate, or that cause kidney damage (e.g. NSAIDs) or that can potentially lead to impairment of haematopoiesis, are administered concomitantly.
Slovenian: To se nanaša zlasti na primere sočasne uporabe zdravil, ki vplivajo na izločanje metotreksata, povzročajo okvaro ledvic (npr. nesteroidna protivnetna zdravila) ali pa lahko vodijo do morebitnih motenj pri tvorbi krvi.
English: Administration of additional haematotoxic medicinal products (e.g. metamizole) increases the likelihood of severe haematotoxic adverse reactions to methotrexate.
Slovenian: Uporaba drugih hematotoksičnih zdravil (npr. metamizola) poveča tveganje za neželene hematotoksične učinke zaradi metotreksata.
English: Prior to initiating therapy, women of childbearing potential must be informed of the risk of malformations associated with methotrexate and any existing pregnancy must be excluded with certainty by taking appropriate measures, e.g. a pregnancy test. During treatment pregnancy tests should be repeated as clinically required (e.g. after any gap of contraception).
Slovenian: Pred začetkom zdravljenja je treba ženske v rodni dobi seznaniti s tveganjem za kongenitalne malformacije, povezanim z metotreksatom, morebitno nosečnost pa z gotovostjo izključiti na ustrezen način, kot je test nosečnosti.
English: Methotrexate is contraindicated during pregnancy in non-oncological indications (see section 4.3).
Slovenian: Pri neonkoloških indikacijah je uporaba metotreksata med nosečnostjo kontraindicirana (glejte poglavje 4.3).
English: − joint or muscle pain, osteoporosis (reduction in bone strength)
Slovenian: − bolečine v sklepih ali mišicah, osteoporoza (zmanjševanje kostne mase),
English: − vomiting blood, severe complications in the digestive tract
Slovenian: − bruhanje krvi, hudi zapleti v prebavilih,
English: • Remarks on the importance of reporting ADRs
Slovenian: • pojasnila glede pomembnosti poročanja o neželenih učinkih zdravila;
English: Dose in rheumatic and skin diseases (RA, JIA and psoriasis or psoriatic arthritis)
Slovenian: Odmerek pri revmatičnih in kožnih boleznih (revmatoidni artritis, JIA in luskavica ali psoriatični artritis)
English: MARKETING AUTHORISATION NUMBER
Slovenian: ŠTEVILKE DOVOLJENJ ZA PROMET Z ZDRAVILOM
English: If acute methotrexate toxicity occurs, patients may require treatment with folinic acid.
Slovenian: Dodajanje folne kisline Pri akutnih toksičnih učinkih metotreksata je bolnike morda treba zdraviti s folinsko kislino.
English: − discoloration of the nails,acne, red or purple spots due to bleeding from blood vessels
Slovenian: − spremenjena barva nohtov, akne, rdeče ali vijolične lise na koži zaradi krvavitev iz žil,
English: − tonsillitis, stopping breathing, asthma
Slovenian: − vnetje žrela, prekinitev dihanja, astma,
English: In therapy-refractory cases the weekly dosage may be increased to 20 mg (10 ml)/m² BSA/week.
Slovenian: Pri bolnikih, ki se ne odzivajo na priporočeni odmerek, se lahko odmerek poveča na 20 mg (10 ml)/m² telesne površine tedensko.
English: As treatment with methotrexate at higher doses commonly used in cancer treatment can cause infertility and genetic mutations, it may be advisable for male patients treated with methotrexate doses higher than 30 mg (15 ml)/week to consider sperm preservation before the beginning of treatment (see also section "Warnings and precautions").
Slovenian: je za bolnike, ki se zdravijo z odmerki metotreksata, večjimi od 30 mg (15 ml) na teden, priporočljivo, da se pred začetkom zdravljenja pozanimajo o možnostih shranitve semenske tekočine (glejte tudi poglavje „Opozorila in previdnostni ukrepi“).
English: − serious peeling or blistering of the skin
Slovenian: − hudo luščenje kože ali pojav kožnih mehurjev,
English: • Hepatic impairment (bilirubin levels are >5 mg/dl [85.5 µmol/l], see section 4.2)
Slovenian: • preobčutljivost za učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1; • okvara jeter (vrednost bilirubina je > 5 mg/dl [85,5 µmol/l], glejte poglavje 4.2);
English: Please note that this oral solution contains 2 mg methotrexate in 1 ml solution and that the scaling of the dosing syringe is in ml and not mg.
Slovenian: Ne spreglejte, da ta peroralna raztopina vsebuje 2 mg metotreksata v 1 ml raztopine, merilne enote na brizgi za odmerjanje pa so mililitri in ne miligrami.
English: Low-dose methotrexate is used in the maintenance treatment of ALL in children aged 3 years and over, adolescents and adults within complex protocols in combination with other cytostatic medicinal products.
Slovenian: mladostnikih in odraslih je v okviru kompleksnih protokolov v kombinaciji z drugimi citostatiki uporabljen metotreksat v majhnem odmerku.
English: The usual caution should be exercised in handling cytostatics.
Slovenian: Pri rokovanju s citostatiki je potrebna običajna previdnost.
English: Patients with JIA should always be referred to a rheumatology unit specialising in the treatment of children/adolescents.
Slovenian: Bolnike s poliartikularnimi oblikami juvenilnega idiopatičnega artritisa je treba vselej napotiti na oddelek za revmatologijo, ki se ukvarja z zdravljenjem otrok/mladostnikov.
English: A chest X-ray must be taken in order to be able to exclude an infection.
Slovenian: Za izključitev okužbe je potrebno rentgensko slikanje pljuč.
English: Men should not donate semen during therapy or for 6 months following discontinuation of methotrexate.
Slovenian: Moški med zdravljenjem z metotreksatom in še 6 mesecev po njem ne smejo darovati semenske tekočine.
English: When administered in low doses (7.5 mg/m2 to 80 mg/m2 body surface area), the mean bioavailability of methotrexate is approximately 70%, but considerable inter- and intra-individual variations are possible (25-100%).
Slovenian: Pri uporabi manjših odmerkov (od 7,5 mg/m2 do 80 mg/m2 telesne površine) je povprečna biološka uporabnost približno
English: Therapeutic management of overdose
Slovenian: Zdravljenje prevelikega odmerjanja
English: Jylamvo is for oral use only.
Slovenian: Zdravilo Jylamvo je namenjeno samo peroralni uporabi.
English: The application of procarbazine during high-dose methotrexate therapy increases the risk of impairment or renal function
Slovenian: Uporaba prokarbazina med zdravljenjem z visokim odmerkom metotreksata poveča tveganje za oslabljeno delovanje ledvic.
English: Respiratory paralysis, Bronchial asthma-like reactions such as cough, dyspnoea and pathological changes in lung function tests, Pharyngitis
Slovenian: pljučna fibroza respiratorna paraliza, bronhialni astmi podobne reakcije, kot so kašelj, dispneja in patološke spremembe pri preiskavah delovanja pljuč,
English: In patients with unimpaired elimination mechanisms, myelosuppression and mucositis are generally reversible within 14 to 28 days.
Slovenian: Pri bolnikih, pri katerih mehanizmi izločanja niso okvarjeni, sta mielosupresija in mukozitis običajno reverzibilna v času od
English: Severe visual disturbances
Slovenian: − hude motnje vida,
English: Pneumocystis jiroveci pneumonia and other lung infections, Chronic obstructive pulmonary disease, Pleural effusion
Slovenian: faringitis pljučnica, povzročena z mikroorganizmom Pneumocystis jiroveci, in druge okužbe pljuč, kronična obstruktivna pljučna bolezen, plevralni izliv pljučna alveolarna krvavitev3
English: Other frequently (common) occurring adverse reactions are leukopenia, anaemia, thrombopenia, headache, tiredness, drowsiness, pneumonia, interstitial alveolitis/pneumonitis often associated with eosinophilia, oral ulcers, diarrhoea, exanthema, erythema and pruritus.
Slovenian: Drugi pogosti neželeni učinki so levkopenija, anemija, trombocitopenija, glavobol, utrujenost, zaspanost, pljučnica, intersticijski alveolitis/pljučnica, ki je pogosto povezan/(-a) z eozinofilijo, razjede v ustni votlini, driska, eksantem, rdečina in srbenje.
English: How to take Jylamvo
Slovenian: Kako jemati zdravilo Jylamvo
English: The dose should be increased gradually but should not, in general, exceed a weekly dose of 25 mg of methotrexate.
Slovenian: Odmerek se postopno povečuje, a na splošno tedenski odmerek metotreksata ne sme preseči 25 mg. Običajni odmerek je 10 mg-25 mg (5 ml-12,5 ml)
English: The half-life may be prolonged up to four-fold in patients with a third distribution compartment (pleural effusion, ascites).
Slovenian: Pri bolnikih s tretjim prostorom porazdelitve (plevralni izliv, ascites) se razpolovni čas lahko podaljša za do štirikrat.
English: Doses exceeding 20 mg (10 ml) per week can be associated with significant increase in toxicity, especially bone marrow suppression.
Slovenian: Odmerki, ki presegajo 20 mg (10 ml) na teden, so lahko povezani s precejšnjim povečanjem toksičnosti, še posebno z zaviranjem delovanja kostnega mozga.
English: Pleural effusions and ascites should be drained prior to initiation of methotrexate treatment (see section 4.2).
Slovenian: Pred začetkom zdravljenja z metotreksatom je treba plevralne izlive in ascites drenirati (glejte poglavje 4.2).
English: − impaired sperm formation, menstrual disorders.
Slovenian: − zmanjšana tvorba semenske tekočine, motnje v menstrualnem ciklusu.
English: You must avoid becoming pregnant during treatment with methotrexate and for at least 6 months after the end of treatment.
Slovenian: Med zdravljenjem z metotreksatom in še vsaj šest mesecev po koncu zdravljenja ne smete zanositi.
English: Methotrexate can cause miscarriage and severe birth defects.
Slovenian: Metotreksat lahko povzroči splav in hude prirojene okvare pri otroku.
English: In patients simultaneously taking haematotoxic medicinal products (e.g. leflunomide), blood count and platelets should be closely monitored.
Slovenian: Pri bolnikih, ki sočasno jemljejo hematotoksična zdravila (npr. leflunomid), je treba pogosteje spremljati krvno sliko in krvne ploščice.
English: Any serious decrease in leucocyte or platelet counts indicates the immediate discontinuation of treatment and appropriate supportive therapy.
Slovenian: Ob vsakem občutnejšem padcu števila belih krvničk ali krvnih ploščic je treba z uporabo zdravila takoj prekiniti in uvesti ustrezno podporno zdravljenje.