FrancophonIA/ELRC3.0 huggingface dataset:
English: Limited data in patients receiving higher than recommended Zinforo dosages show similar adverse reactions as observed in the patients receiving recommended dosages.
Slovenian: Maloštevilni podatki pri bolnikih, ki so prejeli večje odmerke zdravila Zinforo kot so priporočeni, kažejo podobne neželene učinke kot so bili opaženi pri bolnikih, zdravljenih s priporočenimi odmerki.
English: However, when ceftaroline was administered throughout pregnancy and lactation, there was no effect on pup weight or growth.
Slovenian: Če pa je bil ceftarolin uporabljan med celotno nosečnostjo in dojenjem, niso opazili vpliva na telesno maso ali rast mladičev.
English: It is unknown whether ceftaroline fosamil or ceftaroline is excreted in human milk.
Slovenian: Ni znano, ali se fosamilceftarolin ali ceftarolin pri človeku izloča v materino mleko.
English: Infer susceptibility from susceptibility to benzylpenicillin.
Slovenian: Na občutljivost je treba sklepati na podlagi občutljivosti za benzilpenicilin.
English: Creatinine clearance (mL/min)
Slovenian: Očistek kreatinina (ml/min)
English: In vitro studies have not demonstrated any antagonism between ceftaroline in combination with other commonly used antibacterial agents (e.g. amikacin, azithromycin, aztreonam, daptomycin, levofloxacin, linezolid, meropenem, tigecycline, and vancomycin).
Slovenian: Študije in vitro niso pokazale antagonizma med ceftarolinom v kombinaciji z drugimi pogosto uporabljanimi antibiotiki (npr. z amikacinom, azitromicinom, aztreonamom, daptomicinom, levofloksacinom, linezolidom, meropenemom, tigeciklinom in vankomicinom).
English: Following the administration of a single 600 mg intravenous dose of radiolabelled ceftaroline fosamil to healthy male adults, approximately 88% of radioactivity was recovered in urine and 6% in faeces.
Slovenian: Po uporabi enkratnega intravenskega odmerka 600 mg radioaktivno označenega fosamilceftarolina pri zdravih odraslih moških se je približno 88 % radioaktivnosti pojavilo v urinu in 6 % v blatu.
English: Following administration of a single 600 mg intravenous dose of ceftaroline fosamil, the pharmacokinetics of ceftaroline were similar between healthy elderly subjects (≥ 65 years of age), and healthy young adult subjects (18-45 years of age).
Slovenian: Po uporabi enkratnega intravenskega odmerka 600 mg fosamilceftarolina je bila farmakokinetika ceftarolina pri zdravih starejših preiskovancih (≥ 65 let) podobna kot pri zdravih mladih odraslih (18 - 45 let).
English: You may develop an abnormal lab test (called Coombs test) that looks for certain antibodies which may act against your red blood cells.
Slovenian: Pojavi se vam lahko nenormalen izvid določene laboratorijske preiskave (imenujemo jo Coombsov test); ta preiskava odkriva posebna protitelesa, ki lahko delujejo proti rdečim krvnim celicam.
English: Resistance may also be mediated by bacterial impermeability or drug efflux pump mechanisms.
Slovenian: Odpornost je prav tako lahko posledica bakterijske neprepustnosti ali mehanizmov izlivnih črpalk za izplavljanje zdravila.
English: Ceftaroline is primarily eliminated by the kidneys.
Slovenian: Ceftarolin se izloči predvsem skozi ledvice.
English: How Zinforo works Zinforo works by killing certain bacteria, which can cause serious infections.
Slovenian: Kako deluje zdravilo Zinforo Zdravilo Zinforo deluje tako, da uničuje določene bakterije, ki lahko povzročijo hude okužbe.
English: Zinforo is indicated for the treatment of the following infections in neonates, infants, children, adolescents and adults(see sections 4.4 and 5.1):
Slovenian: Zdravilo Zinforo je indicirano pri novorojenčkih, dojenčkih, otrocih, mladostnikih in odraslih za zdravljenje naslednjih okužb (glejte poglavji 4.4 in 5.1):
English: The available clinical data cannot substantiate efficacy against penicillin non-susceptible strains of S. pneumoniae.
Slovenian: Klinični podatki, ki so na voljo, ne dokazujejo učinkovitosti proti sevom S. pneumoniae, neobčutljivim za penicilin.
English: Patients experiencing anaemia during or after treatment with Zinforo should be investigated for this possibility.
Slovenian: Zato je treba bolnike, pri katerih se med zdravljenjem z zdravilom Zinforo ali po njem pojavi anemija, pregledati glede te možnosti.
English: Instructions for the reconstitution of Zinforo vial are summarized below:
Slovenian: Navodila za pripravo viale zdravila Zinforo so povzeta spodaj:
English: 400 mg c/every 12 hours
Slovenian: 400 mg c/vsakih 12 ur
English: Standard aseptic techniques should be used for solution preparation and administration.
Slovenian: Za pripravo in dajanje raztopine je treba uporabiti standardne aseptične postopke.
English: Once removed from refrigeration to room temperature, the diluted product must be used within 6 hours.
Slovenian: Ko je razredčeno zdravilo enkrat vzeto iz hladilnika in dano na sobno temperaturo, ga je treba uporabiti v 6 urah.
English: Your doctor may increase your dose to 600 mg every 8 hours for some infections.
Slovenian: Pri nekaterih okužbah lahko zdravnik odmerek poveča na 600 mg na 8 ur.
English: However, the frequency of rash in the subgroup of Asian patients receiving Zinforo every 8 hours was very common (18.5%).
Slovenian: V podskupini azijskih bolnikov, zdravljenih z zdravilom Zinforo na 8 ur, pa se je izpuščaj pojavil s pogostnostjo zelo pogosti (18,5 %).
English: The recommended dosage of Zinforo shown in Table 2 for paediatric patients < 2 months of age are based on pharmacokinetic-pharmacodynamic modelling and simulation.
Slovenian: Priporočeni odmerki zdravila Zinforo, prikazani v preglednici 2, za pediatrične bolnike stare < 2 meseca, temeljijo na farmakokinetično-farmakodinamičnem modeliranju in simulacijah.
English: Alternatively they are stable for up to 24 hours under refrigerated storage.
Slovenian: Če so shranjene v hladilniku, so stabilne do 24 ur.
English: Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of ceftaroline fosamil (see section 4.8).
Slovenian: Zato je na to diagnozo treba pomisliti pri vseh bolnikih, ki se jim med uporabo fosamilceftarolina ali po njej pojavi driska (glejte poglavje 4.8).
English: Dose adjustments are required for neonates, infants, children and adolescents with bodyweight < 33 kg (see section 4.2).
Slovenian: Odmerek je treba prilagoditi pri novorojenčkih, dojenčkih, otrocih in mladostnikih s telesno maso < 33 kg (glejte poglavje 4.2).
English: As a result, minimum inhibitory concentrations (MICs) of ceftaroline against a proportion of these organisms tested fall into the susceptible range (see Resistance section below).
Slovenian: Zato bi morala biti minimalna inhibitorna koncentracija (MIK) ceftarolina za delež testiranih organizmov območju občutljivosti (glejte poglavje Odpornost, spodaj).
English: Anaemia, leucopenia, neutropenia, thrombocytopenia, prothrombin time (PT) prolonged, activated partial thromboplastin time (aPTT) prolonged, international normalized ratio (INR) increased
Slovenian: Bolezni krvi in limfatičnega sistema anemija, levkopenija, nevtropenija, trombocitopenija, podaljšan protrombinski čas (PČ), podaljšan aktiviran parcialni tromboplastinski čas (aPTČ), povečanje mednarodnega umerjenega razmerja (INR)
English: It belongs to a group of medicines called ‘cephalosporin antibiotics.'
Slovenian: Spada v skupino zdravil, imenovanih cefalosporinski antibiotiki.
English: Clinical study experience with ceftaroline fosamil in patients with pre-existing seizure disorders is very limited.
Slovenian: Izkušenj iz kliničnih študij s fosamilceftarolinom pri bolnikih z obstoječo konvulzivno motnjo je zelo malo.
English: Seizures have occurred in toxicology studies at 7-25 times human ceftaroline Cmax levels (see section 5.3).
Slovenian: V toksikoloških študijah so se pri koncentracijah ceftarolina, ki so bile od 7- do 25-kratnik Cmax pri človeku, pojavile konvulzije (glejte poglavje 5.3).
English: 10 mg/kg 120/every 8 hours
Slovenian: 10 mg/kg 120/vsakih 8 ur
English: Zinforo is used to treat children (from birth) and adults with:
Slovenian: Za kaj uporabljamo zdravilo Zinforo Zdravilo Zinforo se uporablja za zdravljenje otrok (od rojstva) in odraslih z:
English: Ceftaroline is not active against strains of Enterobacterales producing extended-spectrum betalactamases (ESBLs) from the TEM, SHV or CTX-M families, serine carbapenemases (such as KPC), class B metallo-beta-lactamases or class C (AmpC) cephalosporinases.
Slovenian: Ceftarolin ni aktiven proti sevom Enterobacterales, ki tvorijo betalaktamaze razširjenega spektra (ESBL - extended-spectrum beta-lactamases) iz družin TEM, SHV in CTX-M, serinske karbapenemaze (npr. KPC), metalo-betalaktamaze skupine B ali skupino C (AmpC) cefalosporinaz.
English: The contents of Zinforo vial should be reconstituted with 20 mL of sterile water for injections.
Slovenian: Vsebino viale zdravila Zinforo je treba pripraviti z 20 ml sterilne vode za injekcije.
English: Patients who have a history of hypersensitivity to cephalosporins, penicillins or other beta-lactam antibacterials may also be hypersensitive to ceftaroline fosamil.
Slovenian: Bolniki z anamnezo preobčutljivosti za cefalosporine, peniciline ali druga betalaktamska zdravila za zdravljenje bakterijskih okužb so lahko preobčutljivi tudi na fosamilceftarolin.
English: The bactericidal action of ceftaroline is mediated through binding to essential penicillinbinding proteins (PBPs).
Slovenian: Ceftarolin deluje baktericidno z vezavo na esencialne penicilin vežoče beljakovine (PBPpenicillin binding proteins).
English: A pale yellowish-white to light yellow powder.
Slovenian: bledo rumenkastobel do svetlo rumen prašek
English: The recommended dosages of Zinforo shown in Tables 1 to 4 for the treatment of cSSTI caused by S. aureus with ceftaroline MIC of 2 or 4 mg/L are based on pharmacokineticpharmacodynamic modelling and simulation (see sections 4.2 and 5.1).
Slovenian: Priporočeni odmerki zdravila Zinforo, prikazani v preglednicah 1-4, za zdravljenje zapletenih okužb kože in mehkih tkiv s S. aureus, pri katerih je MIK za ceftarolin od 2 do 4 mg/l, temeljijo na farmakokinetično-farmakodinamičnem modeliranju in simulacijah (glejte poglavji 4.2 in 5.1).
English: Dose is based on CrCL.
Slovenian: Odmerek temelji na očistku kreatinina.
English: How to use Zinforo
Slovenian: Kako uporabljati zdravilo Zinforo
English: • Staphylococcus aureus (including methicillin-resistant strains)
Slovenian: • Staphylococcus aureus (vključno s sevi, odpornimi proti meticilinu)
English: Parenteral drug products should be inspected visually for particulate matter prior to administration.
Slovenian: Zdravila za parenteralno uporabo je treba pred uporabo pregledati glede prisotnosti delcev.
English: The effects of ceftaroline fosamil on fertility on humans have not been studied.
Slovenian: Vpliv fosamilceftarolina na plodnost pri človeku ni raziskan.
English: Ceftaroline fosamil (prodrug) is converted into the active ceftaroline in plasma by phosphatase enzymes and concentrations of the prodrug are measurable in plasma primarily during intravenous infusion.
Slovenian: Fosamilceftarolin (predzdravilo) se v plazmi spremeni v aktivni ceftarolin z delovanjem fosfataz; koncentracija predzdravila je v plazmi merljiva predvsem med intravenskim infundiranjem.
English: The safety assessment in paediatric patients is based on the safety data from 2 trials in which 227 patients aged from 2 months to 17 years with cSSTI or CAP received Zinforo.
Slovenian: Ocena varnosti pri pediatričnih bolnikih temelji na podatkih o varnosti iz 2 preskušanj, v katerih je zdravilo Zinforo prejemalo 227 bolnikov, starih od 2 mesecev do 17 let, ki so imeli zapletene okužbe kože in mehkih tkiv oziroma zunajbolnišnično pljučnico.
English: Ceftaroline is a cephalosporin antibacterial with in vitro activity against Gram-positive and -negative bacteria.
Slovenian: Ceftarolin je cefalosporinski antibiotik z in vitro aktivnostjo proti Grampozitivnim in Gramnegativnim bakterijam.
English: • If you have ever had fits (seizures or convulsions)
Slovenian: • če ste kdaj imeli napad krčev (epileptični napad ali epileptične krče),
English: • an infection of the lungs called ‘pneumonia'
Slovenian: • okužbo pljuč, ki jo imenujemo pljučnica.
English: Other medicines and Zinforo Tell your doctor or nurse if you are using, have recently used or might use any other medicines.
Slovenian: Obvestite zdravnika ali medicinsko sestro, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli zdravilo.
English: • Changes in a blood test called a ‘Coombs test' commonly seen in patients receiving this type of antibiotic.
Slovenian: • pri bolnikih, ki prejemajo to vrsto antibiotikov, je pogosta sprememba izvida preiskave krvi, imenovane "Coombsov test".
English: Agranulocytosis, eosinophilia
Slovenian: Agranulocitoza, eozinofilija
English: For treatment of S. aureus for which the ceftaroline MIC is ≤ 1 mg/L, the standard dose is recommended.
Slovenian: Za zdravljenje okužb s S. aureus, pri katerih je MIK ceftarolina ≤ 1 mg/l, je priporočen običajni odmerek.
English: As ceftaroline does not appear to undergo significant hepatic metabolism, the systemic clearance of ceftaroline is not expected to be significantly affected by hepatic impairment.
Slovenian: Ker v jetrih ni pomembne presnove ceftarolina, ni pričakovati, da bi okvara jeter bistveno prizadela sistemski očistek ceftarolina.
English: Store below 30°C.
Slovenian: Shranjujte pri temperaturi do 30°C.
English: Rash, pruritus Anaphylaxis, hypersensitivity (e.g. urticaria, lip and face swelling) (see sections 4.3 and 4.4)
Slovenian: Bolezni imunskega sistema izpuščaj, pruritus anafilaksija, preobčutljivost (npr. urtikarija, oteklina ustnic in obraza) (glejte poglavji 4.3 in 4.4)
English: 20 mL glass vial (Type 1) closed with a rubber (halobutyl) stopper and aluminium seal with flip-off cap.
Slovenian: 20 ml steklena viala (iz stekla tipa 1), zaprta z gumijastim (halobutilnim) zamaškom, aluminijsko zaporo in odstranljivim pokrovčkom.
English: Diarrhoea, nausea, vomiting, abdominal pain
Slovenian: Bolezni prebavil driska, navzea, bruhanje, bolečine v trebuhu
English: If you use more Zinforo than you should If you think you have been given too much Zinforo, tell your doctor or nurse straight away.
Slovenian: Če ste uporabili večji odmerek zdravila Zinforo, kot bi smeli Če menite, da ste dobili preveč zdravila Zinforo, to nemudoma povejte zdravniku ali medicinski sestri.
English: Following administration throughout pregnancy and lactation in the rat, there was no effect on pup birth weight or growth, although minor changes in foetal weight and delayed ossification of the interparietal bone were observed when ceftaroline fosamil was administered during organogenesis (see section 5.3).
Slovenian: Po uporabi med celotnim obdobjem brejosti in laktacije pri podganah ni bilo učinkov na porodno maso ali rast mladičev, čeprav so pri uporabi fosamilceftarolina med organogenezo opazili manjše spremembe v masi ploda in zapoznelo osifikacijo interparietalne kosti (glejte poglavje 5.3).
English: Clostridium difficile-associated diarrhoea
Slovenian: Driska, povezana s Clostridium difficile
English: Zinforo powder should be reconstituted with 20 mL of sterile water for injections.
Slovenian: Prašek Zinforo je treba pripraviti z 20 ml sterilne vode za injekcije.
English: • If you have had previous severe allergic reactions to other antibiotics like penicillin or carbapenem.
Slovenian: • če ste že imeli hudo alergijsko reakcijo na druge antibiotike, npr. penicilin, karbapenem.
English: Adolescents aged from 12 to < 18 years with bodyweight ≥ 33 kg
Slovenian: mladostniki, stari od 12 do < 18 let, s telesno maso ≥ 33 kg
English: If any of the above apply to you (or you are not sure), talk to your doctor or nurse before using Zinforo.
Slovenian: Če kaj od naštetega velja za vas (ali če ste negotovi), se pred uporabo zdravila Zinforo posvetujte z zdravnikom ali medicinsko sestro.
English: • A significant decrease in the number of certain white blood cells in your blood
Slovenian: • zmanjšanje celotnega števila belih krvnih celic ali določene vrste belih krvnih celic v krvi
English: If you miss a dose of Zinforo If you think you have missed a dose, tell your doctor or nurse straight away.
Slovenian: Če ste izpustili odmerek zdravila Zinforo Če menite, da ste izpustili odmerek, morate to takoj povedati zdravniku ali medicinski sestri.
English: Convulsions have been observed at relatively high exposures during single and multi-dose studies in both the rat and monkey (≥ 7 times to the estimated ceftaroline Cmax level of a 600 mg twice a day).
Slovenian: Pri podganah in opicah so ob uporabi enkratnega in večkratnih odmerkov v študijah pri razmeroma veliki izpostavljenosti (≥ 7-kratnik ocenjene Cmax ceftarolina med uporabo 600 mg dvakrat na dan) opažali konvulzije.
English: There is no experience with ceftaroline in the treatment of cSSTI in the following patient groups: the immunocompromised, patients with severe sepsis/septic shock, necrotizing fasciitis, perirectal abscess and patients with third degree and extensive burns.
Slovenian: O zdravljenju zapletenih okužb kože in mehkih tkiv s ceftarolinom ni nobenih izkušenj pri naslednjih skupinah bolnikov: pri imunsko oslabelih bolnikih, bolnikih s hudo sepso/septičnim šokom, nekrotizirajočim fasciitisom, perirektalnim abscesom in pri bolnikih z obsežnimi opeklinami ali opeklinami tretje stopnje.
English: Clostridium difficile colitis (see section 4.4)
Slovenian: Infekcijske in parazitske bolezni kolitis zaradi Clostridium difficile (glejte poglavje 4.4)
English: There is no experience with ceftaroline in the treatment of CAP in the following patient groups: the immunocompromised, patients with severe sepsis/septic shock, severe underlying lung disease, those with PORT Risk Class V, and/or CAP requiring ventilation at presentation, CAP due to methicillinresistant S. aureus or patients requiring intensive care.
Slovenian: O zdravljenju zunajbolnišnične pljučnice s ceftarolinom ni nobenih izkušenj pri naslednjih skupinah bolnikov: pri imunsko oslabelih bolnikih, bolnikih s hudo sepso/septičnim šokom, hudo osnovno boleznijo pljuč, bolnikih, ki se uvrščajo v V. razred tveganja po sistemu PORT, in/ali bolnikih z zunajbolnišnično pljučnico, ki so ob sprejemu potrebovali ventilacijo, pri bolnikih z zunajbolnišnično pljučnico, katere povzročitelj je proti meticilinu odporni S. aureus, ter pri bolnikih, ki potrebujejo intenzivno nego.
English: Immediate and severe hypersensitivity (e.g. anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g. penicillins or carbapenems).
Slovenian: Takojšnja in huda preobčutljivost (npr. anafilaktična reakcija) na katerokoli drugo vrsto betalaktamskih zdravil za zdravljenje bakterijskih okužb (npr. na peniciline ali karbapeneme).
English: Anaerobic micro-organisms Gram-positive micro-organisms
Slovenian: Anaerobni mikroorganizmi Grampozitivni mikroorganizmi
English: Blood creatinine increased
Slovenian: Bolezni sečil zvišanje kreatinina v krvi
English: • Diarrhoea, stomach pain
Slovenian: • driska, bolečine v trebuhu
English: Hepatic impairment No dosage adjustment is considered necessary in patients with hepatic impairment (see section 5.2).
Slovenian: Okvara jeter Bolnikom z okvaro jeter odmerka ni treba prilagoditi (glejte poglavje 5.2).
English: After reconstitution, 1 mL of the solution contains 30 mg of ceftaroline fosamil.
Slovenian: Po rekonstituciji vsebuje 1 ml raztopine 30 mg fosamilceftarolina.
English: The median steady-state volume of distribution of ceftaroline in healthy adult males following a single 600 mg intravenous dose of radiolabelled ceftaroline fosamil was 20.3 l, similar to the volume of extracellular fluid.
Slovenian: Mediani volumen porazdelitve ceftarolina v stanju dinamičnega ravnovesja je bil pri zdravih odraslih moških po enkratnem intravenskem odmerku 600 mg radioaktivno označenega fosamilceftarolina 20,3 l; ta volumen je podoben volumnu zunajcelične tekočine.
English: The pharmacokinetics of ceftaroline in patients with hepatic impairment has not been established.
Slovenian: Farmakokinetika ceftarolina pri bolnikih z okvaro jeter ni ugotovljena.
English: Efficacy has been demonstrated in clinical studies against the pathogens listed under each indication that were susceptible to ceftaroline in vitro.
Slovenian: Klinična učinkovitost proti specifičnim patogenom Učinkovitost je bila v kliničnih študijah dokazana proti patogenom, ki so našteti pri posamezni indikaciji in so bili in vitro občutljivi za ceftarolin.
English: • An increase in the number of certain white blood cells in your blood (eosinophilia).
Slovenian: • povečanje števila določene vrste belih krvnih celic v krvi (eozinofilija)
English: The reconstituted solution must be further diluted to produce Zinforo solution for infusion.
Slovenian: Pripravljeno raztopino je treba dodatno redčiti, da nastane raztopina za infundiranje Zinforo.
English: The dose should be adjusted when creatinine clearance (CrCL) is ≤ 50 mL/min, as shown in Tables 3 and 4 (see section 5.2).
Slovenian: Če je očistek kreatinina (CrCL) ≤ 50 ml/min, je treba odmerek prilagoditi, kot prikazujeta preglednici 3 in 4 (glejte poglavje 5.2).
English: There are no or limited amount of data from the use of ceftaroline fosamil in pregnant women.
Slovenian: Podatkov o uporabi fosamilceftarolina pri nosečnicah ni ali jih je malo.
English: As with other beta-lactam antimicrobial agents, the percent time above the minimum inhibitory concentration (MIC) of the infecting organism over the dosing interval (%T > MIC) has been shown to be the parameter that best correlates with the efficacy of ceftaroline.
Slovenian: Tako kot velja za druga betalaktamska protimikrobna zdravila, tudi z učinkovitostjo ceftarolina dokazano najbolje korelira odstotek časa, med katerim je v odmernem intervalu koncentracija višja od MIK za povzročitelja okužbe (% t > MIK).
English: The recommended durations of treatment are 5-14 days for cSSTI and 5-7 days for CAP.
Slovenian: Odmerjanje Priporočeno trajanje zdravljenja je 5-14 dni pri cSSTI in 5-7 dni pri ZBP.
English: The resulting solution should be shaken prior to being transferred to an infusion bag or bottle containing either sodium chloride 9 mg/mL (0.9%) solution for injection, dextrose 50 mg/mL (5%) solution for injection, sodium chloride 4.5 mg/mL and dextrose 25 mg/mL solution for injection (0.45% sodium chloride and 2.5% dextrose) or Lactated Ringer's solution.
Slovenian: Nastalo raztopino je treba pretresti, preden se jo prenese v infuzijsko vrečko ali steklenico, ki vsebuje natrijev klorid 9 mg/ml (0,9 %) raztopino za injiciranje, glukozo 50 mg/ml (5 %) raztopino za injiciranje, natrijev klorid 4,5 mg/ml in glukozo 25 mg/ml raztopino za injiciranje (0,45 % natrijev klorid in 2,5 % glukoza) ali raztopino Ringerjevega laktata.
English: PK-PD analyses suggest that dosing of adults or adolescents (from 12 years and 33 kg) with ceftaroline every 8 hours using 2-hour infusions may treat cSSTI due to S. aureus for which the ceftaroline MIC is 4 mg/L.
Slovenian: FK-FD analize kažejo, da lahko pri odraslih in mladostnikih (od 12 let in 33 kg) uporaba ceftarolina na 8 ur v 2-urnih infuzijah ozdravi zapletene okužbe kože in mehkih tkiv s S. aureus, za katerega je MIK ceftarolina 4 mg/l.
English: Ceftaroline or ceftaroline fosamil are not metabolised by CYP450 enzymes in vitro, therefore co-administered CYP450 inducers or inhibitors are unlikely to influence the pharmacokinetics of ceftaroline.
Slovenian: Ceftarolin ali fosamilceftarolin se in vitro ne presnavljata z encimi CYP450, zato ni verjetno, da bi njuna sočasna uporaba z induktorji ali zaviralci CYP450 vplivala na farmakokinetiko ceftarolina.
English: Complicated skin and soft tissue infections
Slovenian: Zapletene okužbe kože in mehkih tkiv
English: The interaction potential of ceftaroline or ceftaroline fosamil on medicinal products metabolised by CYP450 enzymes is expected to be low since they are not inhibitors nor inducers of CYP450 enzymes in vitro.
Slovenian: Možnost za medsebojno delovanje ceftarolina ali fosamilceftarolina z zdravili, ki se presnavljajo z encimi CYP450, je predvidoma majhna, ker in vitro niti ne zavirata niti ne inducirata encimov CYP450.