FrancophonIA/ELRC3.0 huggingface dataset:
English: In vitro data indicate that ketoconazole is a potent inhibitor of OATP1B1, OATP1B3, OAT3, OCT1 and OCT2 and to a lesser extent of OAT1 and BSEP.
Croatian: In vitro podaci pokazuju da je ketokonazol snažan inhibitor prijenosnika OATP1B1, OATP1B3, OAT3, OCT1 i OCT2 te, u manjoj mjeri, OAT1 i BSEP.
English: More than 800 patients have been treated with ketoconazole with variable treatment duration and modalities.
Croatian: Više od 800 bolesnika liječeno je ketokonazolom u različitom trajanju liječenja i prema različitim modalitetima.
English: In a Canadian study, of the 12 assessable patients (out of 15), 10 showed a reduction in urinary free cortisol levels, but only five had complete resolution on ketoconazole doses 400 to 1200 mg/day.
Croatian: U kanadskoj studiji od 12 bolesnika pogodnih za ocjenjivanje (od ukupno 15) u 10 je došlo do smanjenja razina slobodnog kortizola u urinu, no samo je u 5 bolesnika došlo do potpunog oporavka pri dozama ketokonazola od 400 do 1200 mg/dan.
English: Each tablet contains 19 mg of lactose (as monohydrate).
Croatian: Jedna tableta sadrži 19 mg laktoze (u obliku hidrata).
English: Some combinations may lead to an increased risk of ventricular tachyarrhythmias, including occurrences of torsade de pointes, a potentially fatal arrhythmia (see Table 1 Interactions and recommendations for co-administration, section 4.5).
Croatian: Neke kombinacije mogu uzrokovati povećan rizik od ventrikularne tahiaritmije, uključujući pojavu torsade de pointes, potencijalno fatalne aritmije (vidjeti Tablicu 1, Interakcije i preporuke za istovremenu primjenu, dio 4.5).
English: The degrees of interaction mentioned below are not absolute values and may be dependent on the ketoconazole dose given, i.e. many results are reported following a ketoconazole dose of 200 mg and a stronger interaction may be expected at a higher dose and/or shorter dosing interval.
Croatian: Stupnjevi interakcije navedeni u nastavku nisu apsolutne vrijednosti i mogu ovisiti o primijenjenoj dozi ketokonazola, tj. mnogi rezultati prijavljeni su nakon primjene doze ketokonazola od 200 mg, a jače interakcije mogu se očekivati pri višim dozama i/ili kraćim intervalima doziranja.
English: Treatment should be initiated and supervised by physicians experienced in endocrinology or internal medicine and having the appropriate facilities for monitoring of biochemical responses since the dose must be adjusted to meet the patient's therapeutic need, based on the normalisation of cortisol levels.
Croatian: Liječenje treba započeti i nadzirati liječnik s iskustvom u endokrinologiji ili internoj medicini te odgovarajućom opremom za praćenje biokemijskih odgovora jer je dozu nužno prilagoditi terapijskim potrebama bolesnika na temelju normalizacije razina kortizola.
English: Clinical improvement in hypokalaemia, metabolic alkalosis, diabetes mellitus, and hypertension occurred even in the absence of complete hormonal response.
Croatian: Do kliničkog poboljšanja hipokalijemije, metaboličke alkaloze, dijabetesa melitusa i hipertenzije došlo je i bez potpunog hormonalnog odgovora.
English: At clinically relevant concentrations inhibition of CYP2B6, 2C9/C8, 2C19 and 2D6 by ketoconazole cannot be excluded.
Croatian: Pri klinički značajnim koncentracijama inhibicijski učinak ketokonazola na CYP2B6, 2C9/C8, 2C19 i 2D6 ne može se isključiti.
English: Analgesic opioid Methadone
Croatian: Opioidni analgetici Metadon
English: Warfarin and other coumarin-like drugs
Croatian: Varfarin i drugi lijekovi slični kumarinu
English: Based on limited data, pharmacokinetics parameters (AUC, Cmax and half-life) of ketoconazole for doses of 5 to 10 mg/kg/days, corresponding approximately to daily doses of 200-800 mg, are similar in paediatric and adult population.
Croatian: Ograničeni podaci pokazuju da su farmakokinetički parametri (AUC, Cmax i poluvijek) ketokonazola za doze od 5 do 10 mg/kg/dan, što približno odgovara dnevnoj dozi od 200 do 800 mg, slični u pedijatrijskih i odraslih bolesnika.
English: - Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP.
Croatian: - Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake
English: A 17 years old girl was treated on ketoconazole 1,200 mg/day for an adrenal carcinoma with liver metastasis and had altered liver function tests at 22 days.
Croatian: Djevojka od 17 godina liječena je ketokonazolom u dozi od 1200 mg/dan za adrenalni karcinom s metastazama na jetri te je nakon 22 dana imala promijenjene vrijednosti jetrene funkcije.
English: Doses of 25 mg/kg and higher in male rats and dogs produced sperm abnormalities and decreased fertility in rats.
Croatian: Doze od 25 mg/kg i više u mužjaka štakora i pasa uzrokovale su abnormalnosti u spermi i smanjile plodnost štakora.
English: The recommended initial dose is usually 600 mg per day taken orally (3 tablets per day in 3 divided times).
Croatian: Preporučena početna doza obično iznosi 600 mg na dan kroz usta (3 tablete na dan podijeljene u 3 doze).
English: Careful monitoring and dose adjustment of these medicinal products may be required.
Croatian: Može biti potrebno pažljivo praćenje i prilagodba doze ovih lijekova.
English: Patients should be advised against alcohol consumption while on treatment (see section 4.5).
Croatian: Bolesnicima je potrebno savjetovati da tijekom liječenja ne konzumiraju alkohol (vidjeti dio 4.5).
English: In case of co-administration of an medicinal product known to increase QTc interval (see section 4.5), ECG monitoring is recommended.
Croatian: U slučaju istovremene primjene lijeka za koji se zna da produljuje QTc interval (vidjeti dio 4.5) preporučuje se praćenje EKG-om.
English: Antineoplastics Irinotecan
Croatian: Antineoplastici Irinotekan
English: Patients treated with a block-and-replace regimen should be taught to adjust their glucocorticoid replacement therapy dose under conditions of stress (see section 4.2).
Croatian: Bolesnike s režimom liječenja blokadom i nadomještanjem treba naučiti da u uvjetima stresa prilagode dozu nadomjesne terapije glukokortikoidima (vidjeti dio 4.2).
English: o weekly for one month after initiation of the treatment o then monthly for 6 months o weekly during one month whenever the dose was increased.
Croatian: o jednom tjedno tijekom mjesec dana od početka liječenja o zatim jednom mjesečno tijekom 6 mjeseci o jednom tjedno tijekom mjesec dana nakon svakog povećanja doze.
English: Studies in animal have shown reproductive toxicity (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su reproduktivnu toksičnost (vidjeti dio 5.3).
English: Repeated doses of 200 mg ketoconazole daily resulted in a 17-fold increase in dronedarone exposure
Croatian: Ponovljene doze od 200 mg ketokonazola dnevno uzrokovale su 17erostruko povećanje izloženosti dronedaronu.
English: After ketoconazole withdrawal, liver enzymes returned to normal levels within 3 weeks (section 5.1).
Croatian: Nakon ukidanja ketokonazola razine jetrenih enzima normalizirale su se unutar 3 tjedna (dio 5.1).
English: There is no known antidote to ketoconazole.
Croatian: Ne postoji poznati antidot za ketokonazol.
English: In the literature, among 24 paediatric patients treated with ketoconazole, two developed severe hepatoxicity.
Croatian: U literaturi se navodi da je od 24 pedijatrijska bolesnika liječena ketokonazolom dvoje razvilo tešku hepatotoksičnost.
English: Ketoconazole has not been demonstrated to induce its own metabolism.
Croatian: Nije dokazano da ketokonazol inducira vlastiti metabolizam.
English: • Photosensitivity (increase in the reaction to sunlight: redness, itching rash)
Croatian: • fotoosjetljivost (pojačana reakcija na sunčevu svjetlost: crvenilo, osip koji svrbi)
English: The safety of ketoconazole has been evaluated based on published literature and use of ketoconazole as an antifungal treatment.
Croatian: Sigurnost ketokonazola ocijenjena je na temelju objavljene literature i primjene ketokonazola kao antimikotika.
English: Cushing's syndrome is caused by overproduction of a hormone called cortisol which is produced by the adrenal glands.
Croatian: Cushingov sindrom uzrokuje prekomjerna proizvodnja hormona koji se zove kortizol, a proizvodi se u nadbubrežnim žlijezdama.
English: Not recommended due to a potential increase in colchicine-related toxicity.
Croatian: Ne preporučuje se zbog potencijalnog povećanja toksičnosti povezane s kolhicinom.
English: Coexisting inflammatory/autoimmune disorders
Croatian: Koegzistirajući upalni/autoimuni poremećaji
English: If you interrupt your treatment with Ketoconazole HRA your cortisol level may increase again and your symptoms may come back.
Croatian: Ako prekinete liječenje Ketoconazoleom HRA, Vaše će se razine kortizola možda opet povećati i može doći do ponovne pojave simptoma.
English: A 14 year-old girl who was treated for Cushing's disease with ketoconazole 200 mg twice daily presented one month later with jaundice, fever anorexia, nausea and vomiting.
Croatian: Djevojka od 14 godina koja je liječena ketokonazolom u dozi od 200 mg dvaput dnevno za Cushingovu bolest mjesec dana kasnije imala je žuticu, vrućicu, anoreksiju, mučninu i povraćanje.
English: Ketoconazole did not produce any change in rosuvastatin pharmacokinetics, therefore, co-administration of ketoconazole and rosuvastatin is unlikely to increase the risk of toxicity of rosuvastatin.
Croatian: Ketokonazol nije uzrokovao promjene u farmakokinetici rosuvastatina, stoga je malo vjerojatno da će istovremena primjena ketokonazola i rosuvastatina povećati rizik od toksičnosti rosuvastatina.
English: Ketoconazole at doses up to 40 mg/kg had no effects on female fertility in the rat, whilst doses of 75 mg/kg and higher decreased the pregnancy rate and the number of implantation sites.
Croatian: Ketokonazol u dozama do 40 mg/kg nije utjecao na plodnost ženki štakora, dok su doze od 75 mg/kg i više uzrokovale smanjenje stope trudnoća i broj mjesta implantacije.
English: Preclinical data show that ketoconazole crosses the placenta and is teratogenic.
Croatian: Neklinički podaci pokazuju da ketokonazol prolazi kroz placentu i da je teratogen.
English: Do not drive or operate machines if you experience these symptoms.
Croatian: Ako osjetite ove simptome, nemojte voziti ili upravljati strojevima.
English: • Dry mouth
Croatian: • suhoća usta
English: Within the first hour after ingestion gastric lavage may be performed.
Croatian: Unutar prvog sata od ingestije može se obaviti ispiranje želuca.
English: Use with pasireotide
Croatian: Uporaba s pasireotidom
English: • Azoospermia (no sperm count)
Croatian: • azoospermija (odsutnost spermija)
English: At treatment initiation, 24-hour urinary free cortisol should be controlled every few days/weeks.
Croatian: Na početku liječenja potrebno je svakih nekoliko dana/tjedana kontrolirati razine slobodnog kortizola u 24satnom urinu.
English: Buprenorphine IV and sublingual
Croatian: Buprenorfin intravenski i sublingvalno
English: Ketoconazole can be resumed thereafter at a lower dose (see section 4.2).
Croatian: Primjena ketokonazola se nakon toga može nastaviti pri nižoj dozi (vidjeti dio 4.2).
English: Ketoconazole should not be administered when liver enzymes are greater than 2 times the upper limit of normal or in association with other hepatotoxic medicinal products.
Croatian: Ketokonazol se ne smije primjenjivati ako su razine jetrenih enzima više od 2 puta veće od gornje granice normalnih vrijednosti ili u kombinaciji s drugim hepatotoksičnim lijekovima.
English: Ketoconazole has a high potential for clinically important medicinal products interactions.
Croatian: Ketokonazol ima visok potencijal za klinički značajne interakcije s drugim lijekovima.
English: Although data are limited, the pharmacokinetics of ketoconazole are not significantly different in patients with renal failure compared to healthy subjects, and no specific dose adjustment is recommended in this population.
Croatian: Iako su podaci ograničeni, farmakokinetika ketokonazola ne razlikuje se značajno u bolesnika s oštećenjem bubrega u odnosu na zdrave ispitanike te se za tu populaciju ne preporučuje posebna prilagodba doze.
English: The efficacy and safety of ketoconazole in the treatment of Cushing's syndrome from all causes have been described through several published retrospective studies, chart reviews and case reports.
Croatian: Djelotvornost i sigurnost ketokonazola u liječenju Cushingovog sindroma, neovisno o uzroku, opisana je u nekoliko objavljenih retrospektivnih studija, analiza podataka o bolesnicima i prikazima slučajeva.
English: Ketoconazole is a steroidogenesis inhibitor.
Croatian: Ketokonazol je inhibitor steroidogeneze.
English: Mizolastine Halofantrine
Croatian: Mizolastin Halofantrin
English: Enzyme-inducing medicinal products such as rifampicin, rifabutin, carbamazepine, isoniazid, nevirapine, mitotane and phenytoin may significantly reduce the bioavailability of ketoconazole.
Croatian: Lijekovi koji induciraju enzime poput rifampicina, rifabutina, karbamazepina, izoniazida, nevirapina, mitotana i fenitoina mogu značajno smanjiti bioraspoloživost ketokonazola.
English: Ketoconazole HRA may temporarily lower the amount of hormones produced by your adrenal gland (cortisol) to below the normal range, but your doctor will correct this using appropriate hormone medicines or by adjusting the dose of Ketoconazole HRA.
Croatian: Ketoconazole HRA može privremeno sniziti količinu hormona (kortizola) koju proizvodi Vaša nadbubrežna žlijezda na razine niže od normalnih, ali Vaš će liječnik to ispraviti propisivanjem odgovarajuće hormonske terapije ili prilagodbom doze Ketoconazolea HRA.
English: In addition, they should receive an emergency card and be equipped with an emergency glucocorticoid set.
Croatian: Osim toga, moraju posjedovati iskaznicu za hitne slučajeve i biti opremljeni glukokortikoidnim setom za hitne slučajeve.
English: Menstrual disorder, azoospermia, erectile dysfunction, gynaecomastia
Croatian: Menstrualni poremećaj, azoospermija, erektilna disfunkcija, ginekomastija
English: However, ketoconazole may be an inhibitor of BCRP at the intestinal level at clinically relevant concentrations.
Croatian: Međutim, ketokonazol može biti inhibitor BCRP-a na intestinalnoj razini pri klinički značajnim koncentracijama.
English: Adrenal insufficiency may be detected by periodic clinical assessment and monitoring of plasma/serum or salivary cortisol levels.
Croatian: Adrenalna insuficijencija može se otkriti provođenjem periodičkih kliničkih pretraga i praćenjem razina kortizola u plazmi/serumu ili slini.
English: • Menstrual disorders
Croatian: • menstrualni poremećaji
English: As a minimum requirement, women of childbearing potential must use an effective method of contraception (see section 4.6).
Croatian: Minimalni je uvjet da žene u reproduktivnoj dobi moraju koristiti učinkovitu kontracepciju (vidjeti dio 4.6).
English: This medicinal product does not require any special storage conditions.
Croatian: - Lijek ne zahtijeva posebne uvjete čuvanja.
English: Ketoconazole has also been used with other therapies including surgery and pituitary radiation.
Croatian: Ketokonazol se također koristi u kombinaciji s drugim terapijama uključujući operaciju i zračenje hipofize.
English: Coexisting inflammatory/autoimmune disorders Tell your doctor if you suffer from an autoimmune disorder, you will be closely supervised.
Croatian: Istovremeni upalni/autoimuni poremećaji Obavijestite liječnika ako imate autoimuni poremećaj kako bi Vas mogao pomno pratiti.
English: At steady state, mean peak concentrations of 1.7µg/mL to 15.6µg/mL were reported for total daily doses of 200 mg to 1,200 mg.
Croatian: U stanju dinamičke ravnoteže, srednje vršne koncentracije od 1,7 µg/ml do 15,6 µg/ml prijavljene su za ukupne dnevne doze od 200 mg do 1200 mg.
English: Antimigraine Drugs Ergots alkaloids such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine)
Croatian: Lijekovi protiv migrene Ergot-alkaloidi kao što su dihidroergotamin, ergometrin (ergonovin), ergotamin, metilergometrin (metilergonovin)
English: If you take concomitant glucocorticoid replacement therapy with your Ketoconazole HRA treatment, your doctor should inform you how to adapt your glucocorticoid replacement therapy dose if you are under stress or have surgery or an infection.
Croatian: Ako istovremeno s Ketoconazoleom HRA uzimate nadomjesnu terapiju glukokortikoidima, Vaš liječnik objasnit će Vam kako prilagoditi nadomjesnu terapiju glukokortikoidima ako ste pod stresom, morate na operaciju ili imate infekciju.
English: In addition, you should receive an emergency card and should be equipped with an emergency glucocorticoid set.
Croatian: Osim toga morate posjedovati iskaznicu za hitne slučajeve i biti opremljeni glukokortikoidnim setom za hitne slučajeve.
English: Ketoconazole is contraindicated during pregnancy and it should not be used in women of childbearing potential not using an effective method of contraception (see section 4.3).
Croatian: Ketokonazol je kontraindiciran u trudnica i ne smije se upotrebljavati u žena reproduktivne dobi koje ne koriste učinkovitu kontracepciju (vidjeti dio 4.3).
English: Use in ACTH-independent Cushing's syndrome
Croatian: Uporaba kod Cushingovog sindroma neovisnog o ACTH-u
English: • Pyrexia (fever)
Croatian: • pireksija (vrućica)
English: EU/1/14/965/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/14/965/001
English: Talk to your doctor or pharmacist before taking Ketoconazole HRA.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete Ketoconazole HRA.
English: Monitoring for an effect on the QTc interval is advisable.
Croatian: Preporučuje se praćenje učinka na QTc interval.
English: Data on 24 paediatric patients with endogenous Cushing's syndrome treated with ketoconazole are available in the literature, among which 16 were aged over 12 years old and 8 were aged less than 12 years old.
Croatian: U literaturi su dostupni podaci o 24 pedijatrijska bolesnika s endogenim Cushingovim sindromom liječena ketokonazolom od kojih je16 bilo starije od 12 godina, a 8 mlađe od 12 godina.
English: About 75% of patients achieved a decrease of more than 50% of UFC levels on ketoconazole, compared to pre-treatment levels
Croatian: U približno 75 % bolesnika liječenih ketokonazolom razine UFC-a smanjile su se više od 50 % u usporedbi s razinama prije početka liječenja.
English: Considering the rapid absorption of ketoconazole, intake of BCRP substrates should be postponed for 2 hours after ketoconazole intake.
Croatian: S obzirom na brzu apsorpciju ketokonazola, unos supstrata BCRP-a mora se odgoditi za 2 sata nakon unosa ketokonazola.
English: The following list is not an inclusive list of interactions between ketoconazole and other medicinal products
Croatian: Ovaj popis nije sveobuhvatan popis interakcija ketokonazola i drugih lijekova.
English: This leaflet was last revised in. Other sources of information
Croatian: Ova uputa je zadnji put revidirana u
English: Ketoconazole inhibits primarily the activity of 17α-hydroxylase, but it also inhibits 11-hydroxylation steps, and at higher doses the cholesterol side-chain cleavage enzyme.
Croatian: Ketokonazol prvenstveno inhibira aktivnost 17α−hidroksilaze, ali inhibira i korake 11hidroksilacije, a pri višim dozama i enzim cijepanja bočnog lanca kolesterola.
English: Off-white to light cream, round, 10 mm diameter, biconvex.
Croatian: Gotovo bijela do svijetlokrem, okrugla, bikonveksna tableta promjera 10 mm.
English: Antivirals products Saquinavir (saquinavir/ritonavir 1000/100 mg bid)
Croatian: Sakinavir (sakinavir/ritonavir 1000/100 mg dvaput na dan)
English: The recommended dose at initiation in adults and adolescents is 400-600 mg/day taken orally in two or three divided doses and this dose can be increased rapidly to 800-1,200 mg/day in two or three divided doses.
Croatian: Preporučena doza na početku liječenja u odraslih i adolescenata iznosi 400 - 600 mg/dan peroralno, podijeljena u dvije ili tri doze, a brzo se može povisiti na dozu od 800 - 1200 mg/dan podijeljenu u dvije ili tri doze.
English: Other statins that are not CYP3A4 substrates (pravastatin and fluvastatin) can be co-administered with ketoconazole.
Croatian: Ostali statini koji nisu supstrati izoenzima CYP3A4 (pravastatin i fluvastatin) mogu se primjenjivati istovremeno s ketokonazolom.
English: Co-administration of ketoconazole and other medicinal products known to have potentially hepatotoxic effect (eg paracetamol) is not recommended since the combination may lead to increased risk of liver damage.
Croatian: Ne preporučuje se istovremena primjena ketokonazola i drugih lijekova za koje je poznato da imaju potencijalno hepatotoksični učinak (npr. paracetamol) jer njihova kombinacija može povećati rizik od oštećenja jetre.
English: Interactions between ketoconazole and other medicinal products are listed in the table below (increase is indicated as “↑”, decrease as “↓”, an no change as “↔”).
Croatian: U tablici u nastavku prikazane su interakcije ketokonazola i drugih lijekova (povećanje je označeno simbolom „↑”, smanjenje simbolom „↓”, a izostanak promjene simbolom „↔”).
English: Ketoconazole HRA is able to block the activity of the enzymes responsible for the synthesis of cortisol and consequently is able to decrease the over-production of cortisol by your body and to improve the symptoms of Cushing's syndrome.
Croatian: Ketoconazole HRA može sprečavati aktivnost enzima odgovornih za sintezu kortizola te time smanjiti prekomjernu proizvodnju kortizola u Vašem tijelu i poboljšati simptome Cushingovog sindroma.
English: • Nervousness
Croatian: • nervoza
English: It may be necessary to reduce haloperidol dosage.
Croatian: Možda će biti potrebno smanjiti dozu haloperidola.
English: Urological Drugs Fesoterodine Tolterodine Solifenacin
Croatian: Fezoterodin Tolterodin Solifenacin
English: When urinary free/serum/ plasma cortisol levels are normalised or close to target and the effective dose of ketoconazole is established, monitoring can be undertaken every 3 to 6 months (see section 4.2 for dose adjustment in case of adrenal insufficiency).
Croatian: Kada se razine slobodnog kortizola u urinu, odnosno serumskog/plazmatskog kortizola normaliziraju ili su blizu ciljnih vrijednosti, te kada se utvrdi učinkovita doza ketokonazola, praćenje se može obavljati svakih 3 do 6 mjeseci (vidjeti dio 4.2 za prilagodbu doze u slučaju adrenalne insuficijencije).
English: Acid-neutralising medicines (e.g. aluminium hydroxide) should not be administered for at least 2 hours after the intake of ketoconazole.
Croatian: Lijekovi koji neutraliziraju kiselinu (npr. aluminijev hidroksid) ne smiju se primjenjivati najmanje 2 sata nakon unosa ketokonazola.
English: Apart from adrenal blocking effect, ketoconazole may also have direct effects on corticotropic tumour cells in patients with Cushing's disease.
Croatian: Osim supresije nadbubrežne žlijezde, ketokonazol može također izravno utjecati na kortikotropne tumorske stanice u bolesnika s Cushingovom bolesti.
English: No formal evaluation of the effect of age on the pharmacokinetics of ketoconazole has been performed.
Croatian: Nisu provedena službena ispitivanja utjecaja dobi na farmakokinetiku ketokonazola.
English: PVC/Alu blister of 10 tablets Pack sizes containing 60 tablets (6 blisters of 10 tablets).
Croatian: Pakiranje sadrži 60 tableta (6 blistera po 10 tableta).
English: Serious hepatotoxicity, including jaundice, hepatitis, hepatic necrosis, hepatic cirrhosis, hepatic failure including cases necessitating transplantation or resulting in death.
Croatian: Ozbiljna hepatotoksičnost, uključujući žuticu, hepatitis, nekrozu jetre, cirozu jetre, zatajenje jetre, uključujući slučajeve u kojima je potrebna transplantacija ili koji završavaju smrću.
English: Cmax: ↓0.56-fold
Croatian: Cmax: ↓ 0,56 puta