FrancophonIA/ELRC3.0 huggingface dataset:
English: Since the brinzolamide component of SIMBRINZA and its metabolite are excreted predominantly by the kidney, SIMBRINZA is contraindicated in such patients (see section 4.3).
Croatian: Budući da se sastavni dio SIMBRINZE brinzolamid i njegovi metaboliti uglavnom izlučuju putem bubrega, SIMBRINZA je kontraindicirana u tih bolesnika (vidjeti dio 4.3).
English: Check with your doctor, optometrist (optician) or pharmacist if you are not sure.
Croatian: Provjerite s liječnikom, optometristom (optičarem) ili ljekarnikom ako niste sigurni.
English: SIMBRINZA with alcohol
Croatian: SIMBRINZA s alkoholom
English: Specifically, patients wearing contact lenses have not been studied and careful monitoring of these patients when using brinzolamide is recommended, since carbonic anhydrase inhibitors may affect corneal hydration and wearing contact lenses might increase the risk for the cornea (for further instructions on wearing contact lenses, see below under “Benzalkonium chloride”).
Croatian: Konkretno, u ispitivanjima nisu sudjelovali bolesnici koji nose kontaktne leće, stoga se preporučuje pažljivo praćenje tih bolesnika kod primjene brinzolamida, jer inhibitori karboanhidraze mogu utjecati na vlažnost rožnice i nošenje kontaktnih leća kod njihove primjene može povećati rizik za rožnicu (za dodatne upute o nošenju kontaktnih leća vidjeti „Benzalkonijev klorid“ u nastavku).
English: Wearing contact lenses - SIMBRINZA contains benzalkonium chloride
Croatian: Nošenje kontaktnih leća - SIMBRINZA sadrži benzalkonijev klorid
English: Adverse reactions commonly associated with the brimonidine component of SIMBRINZA include the development of ocular allergic type reactions, fatigue and/or drowsiness, and dry mouth.
Croatian: Nuspojave obično povezane sa sastojkom SIMBRINZE brimonidinom uključuju razvoj okularnih alergijskih reakcija, umor i/ili omamljenost, i suha usta.
English: • Chest pain, irregular heart beat
Croatian: • Bol u prsnom košu, nepravilni srčani otkucaji
English: Benzalkonium chloride may also cause eye irritation, especially if you have dry eyes or a disorder of the cornea (the clear layer at the front of the eye).
Croatian: Benzalkonijev klorid može također uzrokovati nadražaj oka, osobito ako imate suhe oči ili poremećaj rožnice (prozirnog sloja prednjeg dijela oka).
English: Brimonidine is primarily eliminated in the urine as metabolites.
Croatian: Brimonidin se prvenstveno eliminira u urin u obiku metabilita.
English: 2, angina pectoris
Croatian: 2, angina pektoris aritmija
English: Eye drops, suspension (eye drops).
Croatian: Kapi za oko, suspenzija (kapi za oko).
English: Not known: arthralgia
Croatian: Nepoznato: artralgija
English: SIMBRINZA should be used with caution in patients with risk of renal impairment because of the possible risk of metabolic acidosis.
Croatian: SIMBRINZA se mora primjenjivati s oprezom u bolesnika kod kojih postoji rizik od oštećenja bubrežne funkcije zbog mogućeg rizika od metaboličke acidoze.
English: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor, optometrist (optician) or pharmacist for advice before taking this medicine.
Croatian: Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku, optometristu (optičaru) ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: SIMBRINZA is used to lower pressure in the eyes in adult patients (aged 18 years and over) who have eye conditions known as glaucoma or ocular hypertension and whose high pressure in the eyes cannot be controlled effectively by one medicine alone.
Croatian: SIMBRINZA se koristi za snižavanje tlaka u očima u odraslih bolesnika (u dobi od 18 i više godina) koji boluju od bolesti oka pod nazivom glaukom ili očna hipertenzija i čiji se tlak u očima ne može učinkovito kontrolirati samo s jednim lijekom.
English: 2, ageusia
Croatian: 2, ageuzija
English: Gently press on the base of the bottle to release one drop of SIMBRINZA.
Croatian: Nježno pritisnite dno boce tako da istekne samo jedna kap SIMBRINZE.
English: In animal studies, brimonidine crossed the placenta and entered into the foetal circulation to a limited extent (see section 5.3).
Croatian: U ispitivanjima na životinjama brimonidin je u ograničenoj mjeri prolazio kroz posteljicu i ulazio u fetalnu cirkulaciju (pogledajte dio 5.3).
English: Very rare (may affect up to 1 in 10,000 people)
Croatian: Vrlo rijetke (mogu se pojaviti u manje od 1 na 10 000 osoba) - Nuspojave na oku: suženje zjenice
English: SIMBRINZA is not recommended during pregnancy and in women of childbearing potential not using contraception.
Croatian: Ne preporučuje se koristiti lijek SIMBRINZA tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju.
English: The effects of renal and hepatic impairment on the systemic pharmacokinetics of brimonidine have not been evaluated.
Croatian: Učinci oštećenja bubrežne i jetrene funkcije na sistemsku farmakokinetiku brimonidina nisu ispitani.
English: Brinzolamide + Brimonidine Mean a
Croatian: Brinzolamid + brimonidin Srednja vrijednost a
English: • Trouble breathing
Croatian: • Poteškoće s disanjem
English: However, the combination product is not recommended for patients with severe renal impairment (creatinine clearance <30 mL/minute).
Croatian: No kombinirani lijek se ne preporučuje bolesnicima s teško oštećenom bubrežnom funkcijom (klirens kreatinina <30 ml/min).
English: Available pharmacodynamic/toxicological data in animals have shown that following oral administration, minimal levels of brinzolamide are excreted in breast milk.
Croatian: Dostupni farmakodinamički/toksikološki podaci u životinja pokazuju da se brinzolamid nakon peroralne primjene izlučuje u majčino mlijeko u minimalnim količinama.
English: However, accumulation of brinzolamide is unlikely as renal elimination is the major route.
Croatian: No nakupljanje brinzolamida nije vjerojatno jer je glavni put njegova uklanjanja putem bubrega.
English: There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and topical brinzolamide.
Croatian: Postoji mogućnost aditivnog učinka na poznate sistemske učinke inhibitora karboanhidraze u bolesnika koji primaju oralne inhibitore karboanhidraze i topikalno primijenjen brinzolamid.
English: Mean percent IOP reductions from baseline with SIMBRINZA ranged from 23 to 34%.
Croatian: Srednji postotak smanjenja IOT-a sa SIMBRINZOM u odnosu na početni kretao se u rasponu od 23% do 34%.
English: Dose related decreases in foetal weights were observed in pups of dams given 2 to 18 mg/kg/day.
Croatian: O dozi ovisno smanjenje tjelesne težine fetusa uočeno je u mladunčadi ženki koje su primale 2 do 18 mg/kg na dan.
English: Uncommon: dermatitis contact
Croatian: Manje često: kontaktni dermatitis
English: Oral carbonic anhydrase inhibitors may impair the ability to perform tasks requiring mental alertness and/or physical coordination in elderly patients.
Croatian: Oralni inhibitori karboanhidraze mogu umanjiti sposobnost obavljanja zadataka koji zahtijevaju mentalnu budnost i/ili tjelesnu koordinaciju kod starijih bolesnika.
English: Caution is advised due to the possibility of an additive or potentiating effect with CNS depressants (e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics).
Croatian: Preporuča se oprez zbog mogućeg aditivnog ili potencirajućeg učinka s depresorima središnjeg živčanog sustava (npr. alkohol, barbiturati, opijati, sedativi ili anestetici).
English: 2, nightmares
Croatian: 2, noćne more
English: SIMBRINZA has not been studied in patients with severe renal impairment (CrCl <30 mL/min) or in patients with hyperchloraemic acidosis.
Croatian: SIMBRINZA nije ispitana u bolesnika s teško oštećenom bubrežnom funkcijom (klirens kreatinina <30 ml/min) niti u bolesnika s hiperkloremijskom acidozom.
English: Brimonidine exhibits affinity for pigmented ocular tissues, particularly iris-ciliary body, due to its known melanin binding properties.
Croatian: Brimonidin iskazuje afinitet za pigmentirana tkiva oka, posebice šarenica-cilijarno tijelo, zbog svog poznatog svojstva vezanja na melanin.
English: The possible effect of brinzolamide on corneal endothelial function has not been investigated in patients with compromised corneas (particularly in patients with low endothelial cell count).
Croatian: Mogući učinak brinzolamida na funkciju endotela rožnice nije ispitivan u bolesnika s oštećenjem rožnice (osobito u bolesnika s niskim brojem stanica endotela).
English: The use of SIMBRINZA is not recommended during pregnancy.
Croatian: Primjena SIMBRINZE ne preporučuje se tijekom trudnoće.
English: These findings were associated with metabolic acidosis with decreased body weight gain in dams and decreased foetal weights.
Croatian: Ti su nalazi bili povezani s metaboličkom acidozom, uz smanjenje prirasta tjelesne težine majki i smanjenje tjelesne težine fetusa.
English: SIMBRINZA can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma.
Croatian: SIMBRINZA može utjecati na druge lijekove i drugi lijekovi mogu utjecati na SIMBRINZU, uključujući druge kapi za oko za liječenje glaukoma.
English: Oral carbonic anhydrase inhibitors may impair the ability of elderly patients to perform tasks requiring mental alertness and/or physical coordination (see section 4.4).
Croatian: Oralni inhibitori karboanhidraze mogu kod starijih bolesnika umanjiti sposobnost obavljanja zadataka koji zahtijevaju mentalnu budnost i/ili fizičku koordinaciju (vidjeti dio 4.4).
English: Uncommon: erectile dysfunction
Croatian: Manje često: erektilna disfunkcija
English: Adults who accidentally swallowed medicines containing brimonidine experienced a decreased heart rate, decreased blood pressure which may be followed by increased blood pressure, heart failure, difficulty breathing and effects in the nervous system.
Croatian: U odraslih koji su greškom progutali lijek koji je sadržavao brimonidin, nastupilo je usporenje pulsa, sniženje krvnog tlaka, nakon čega se krvni tlak mogao povisiti, zatajenje srca, otežano disanje i učinci na živčani sustav.
English: In clinical trials involving SIMBRINZA dosed twice daily the most common adverse reactions were ocular hyperaemia and ocular allergic type reactions occurring in approximately 6-7% of patients, and dysgeusia (bitter or unusual taste in the mouth following instillation) occurring in approximately 3% of patients.
Croatian: U kliničkim ispitivanjima SIMBRINZE primijenjene dva puta dnevno najučestalije nuspojave bile su okularna hiperemija i okularne reakcije alergijskog tipa, koje su zabilježene kod otprilike 6-7% bolesnika te disgeuzija (gorak ili neobičan okus u ustima nakon primjene), zabilježena kod otprilike 3% bolesnika.
English: Write down the date of opening on the carton in the space provided.
Croatian: Na kutiji u predviđeni prostor napišite datum kada ste je otvorili.
English: 3, dysgeusia
Croatian: 3, disgeuzija
English: Likewise, the steady-state plasma pharmacokinetics of brimonidine from the combination were similar to those observed for brimonidine administered alone, with the exception of the twice daily SIMBRINZA treatment group, for which the mean AUC0-12 hours was about 25% lower than that for brimonidine alone administered twice daily.
Croatian: Isto tako, farmakokinetika brimonidina u plazmi u stanju dinamičke ravnoteže iz kombiniranog lijeka bila je slična onoj zabilježenoj s pojedinačno primijenjenim brimonidinom, s iznimkom kod skupine koja je liječena SIMBRINZOM dva puta dnevno, kod koje je srednji AUC0-12 sati bio oko 25% niži nego kod brimonidina primijenjenog pojedinačno dva puta dnevno.
English: Symptoms of brimonidine overdose (including loss of consciousness, hypotension, hypotonia, bradycardia, hypothermia, cyanosis and apnoea) have been reported in neonates and infants receiving brimonidine eye drops as part of medical treatment of congenital glaucoma.
Croatian: Simptomi predoziranja brimonidinom (uključujući gubitak svijesti, hipotenziju, hipotoniju, bradikardiju, hipotermiju, cijanozu i apneju) zabilježeni su kod novorođenih i dojenčadi koji su primali brimonidin kapi za oko kao sastavni dio liječenja kongenitalnog glaukoma.
English: The patient's airway should be maintained.
Croatian: Potrebno je bolesnikov dišni put održavati prohodnim.
English: Pull down your lower eyelid with a clean finger, until there is a ‘pocket' between the eyelid and your eye.
Croatian: Čistim prstom povucite donju vjeđu prema dolje, tako da se između vjeđe i oka stvori „džep“
English: SIMBRINZA may cause dizziness, fatigue and/or drowsiness, which may impair the ability to drive or use machines.
Croatian: SIMBRINZA može uzrokovati omaglicu, umor i/ili omamljenost, što može umanjiti sposobnost upravljanja vozilima i rada sa strojevima.
English: Talk to your doctor, optometrist (optician) or pharmacist before using SIMBRINZA if you have now or have had in the past: - liver problems - a type of high pressure in the eyes called narrow-angle glaucoma - dry eyes or cornea problems - coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, high or low blood pressure - depression - disturbed or poor blood circulation (such as Raynaud's disease, Raynaud's syndrome or cerebral insufficiency).
Croatian: Obratite se svom liječniku, optometristu (optičaru) ili ljekarniku prije nego primijenite SIMBRINZU ako imate ili ste u prošlosti imali: - jetrene tegobe - vrstu visokog tlaka u očima koji se naziva glaukom uskog kuta - suhe oči ili probleme s rožnicom - koronarnu bolest srca (simptomi mogu uključivati bol ili stezanje u prsnom košu, nedostatak zraka ili gušenje), zatajenje srca, povišeni ili sniženi krvni tlak - depresiju - poremećenu ili slabu cirkulaciju krvi (kao što je Raynaudova bolest, Raynaudov sindrom ili cerebralna insuficijencija)
English: Statistically superior reductions in the mean diurnal IOP were observed with SIMBRINZA compared to brinzolamide 10 mg/ml or brimonidine 2 mg/ml dosed twice daily at all visits throughout the study (Figure 1).
Croatian: SIMBRINZOM je postignuto statistički superiorno smanjenje srednjeg dnevnog IOT-a u usporedbi s brinzolamidom 10 mg/ml ili brimonidinom 2 mg/ml dvaput na dan, što se očitovalo pri svakom posjetu tijekom ispitivanja (slika 1).
English: In rats doses of 18 mg/kg/day (783 times the recommended daily clinical dose), but not 6 mg/kg/day, resulted in slightly reduced ossification of skull and sternebrae of foetuses.
Croatian: U štakora je doza od 18 mg/kg/dan (783 puta veća od preporučene dnevne kliničke doze), ali ne i ona od 6 mg/kg/dan, izazvala blago smanjenje osifikacije lubanje i sternebra fetusa.
English: Temporary blurred vision or other visual disturbances may affect the ability to drive or use machines.
Croatian: Privremeno zamagljen vid i drugi poremećaji vida mogu utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: , depressed mood
Croatian: , depresivno raspoloženje nesanica
English: Brinzolamide pharmacokinetics are inherently non-linear due to saturable binding to carbonic anhydrase in whole blood and various tissues.
Croatian: Farmakokinetika brinzolamida je inherentno nelinearna zbog vezanja na karboanhidrazu u kompletnoj krvi i raznim tkivima, koje se može zasititi.
English: The primary metabolite is N-desethylbrinzolamide, followed by the N-desmethoxypropyl and O-desmethyl metabolites, as well as an N-propionic acid analogue formed by oxidation of the N-propyl side chain of O-desmethyl brinzolamide.
Croatian: Glavni metabolit je N-desetilbrinzolamid, nakon čega slijede Ndesmetoksipropil i O-desmetilni metaboliti, kao i analog N-propilne kiseline koji nastaje oksidacijom N-propilnog bočnog lanca O-desmetilbrinzolamida.
English: Caution is advised when using medicinal products such as antihypertensives and/or cardiac glycosides concomitantly with SIMBRINZA or in patients with severe or unstable and uncontrolled cardiovascular disease (see section 4.5).
Croatian: Potreban je oprez pri istodobnoj primjeni SIMBRINZE i lijekova kao što su antihipertenzivi i/ili srčani glikozidi ili kod bolesnika s teškom ili nestabilnom i nekontroliranom kardiovaskularnom bolešću (vidjeti dio 4.5).
English: SIMBRINZA 10 mg/mL + 2 mg/mL eye drops, suspension
Croatian: SIMBRINZA 10 mg/ml + 2 mg/ml kapi za oko, suspenzija
English: • General side effects: decreased blood pressure, chest pain, irregular heartbeat, slow or fast heart rate, palpitations, difficulty sleeping (insomnia), nightmares, depression, generalised weakness, headache, dizziness, nervousness, irritability, general feeling of being unwell, memory loss, shortness of breath, asthma, nose bleeds, cold symptoms, dry nose or throat, sore throat, throat irritation, cough, runny nose, stuffy nose, sneezing, sinus infection, chest congestion, ringing in ear, indigestion, intestinal gas or stomach ache, nausea, diarrhoea, vomiting, abnormal sensation in mouth, increased allergic symptoms on skin, rash, abnormal skin sensation, hair loss, generalised itching, increased blood chlorine levels, or decreased red blood cell count as seen in a blood test, pain, back pain, muscle pain or spasm, kidney pain such as lower back pain, decreased libido, male sexual difficulty.
Croatian: - Opće nuspojave: sniženi krvni tlak, bol u prsnom košu, nepravilni otkucaji srca, usporen ili ubrzan puls, osjećaj lupanja srca, poteškoće sa spavanjem (nesanica), noćne more, depresija, opća slabost, glavobolja, omaglica, nervoza, razdražljivost, opće loše osjećanje, gubitak pamćenja, nedostatak zraka, astma, krvarenje iz nosa, simptomi prehlade, suh nos ili grlo, bol u grlu, nadražaj grla, kašalj, curenje iz nosa, začepljenost nosa, kihanje, infekcija sinusa, kongestija u prsnom košu, zvonjava u uhu, probavne tegobe, plinovi u crijevima ili bol u trbuhu, mučnina, proljev, povraćanje, poremećen osjećaj u ustima, pojačani simptomi alergije na koži, osip, poremećen osjet na koži, gubitak kose, opći svrbež, povišene vrijednosti klora u krvi, ili smanjeni broj crvenih krvnih stanica uočen krvnom pretragom, bol, bol u leđima, bol u mišićima ili grčevi, bol u bubrezima npr. bol u donjem dijelu leđa, oslabljeni spolni nagon, seksualne poteškoće u muškaraca.
English: 2, nervousness
Croatian: 2, nervoza
English: However, caution is advised in patients taking medicinal products which can affect the metabolism and uptake of circulating amines (e.g. chlorpromazine, methylphenidate, reserpine, serotoninnorepinephrine reuptake inhibitors).
Croatian: Međutim, preporučuje se oprez u bolesnika koji koriste lijekove koji mogu utjecati na metabolizam i pohranu amina iz krvotoka ( npr. klorpromazin, metilfenidat, rezerpin, inhibitori ponovne pohrane serotonina i norepinefrina).
English: Patients must be instructed to remove contact lens prior to application of SIMBRINZA and wait at least 15 minutes before reinsertion.
Croatian: Bolesnike se mora uputiti da prije primjene SIMBRINZE izvade kontaktne leće te da pričekaju barem 15 minuta prije njihova ponovnog stavljanja.
English: Always use this medicine exactly as your doctor, optometrist (optician) or pharmacist has told you.
Croatian: Uvijek primijenite ovaj lijek točno onako kako Vam je rekao liječnik, optometrist (optičar) ili ljekarnik.
English: SIMBRINZA has not been studied in patients with narrow-angle glaucoma and its use is not recommended in these patients.
Croatian: SIMBRINZA nije ispitana u bolesnika s glaukomom uskog kuta te se primjena kod ovih bolesnika ne preporuča.
English: Twist off the bottle cap. After the cap is removed, if the tamper evident snap collar is loose, remove it before using the medicine.
Croatian: Nakon skidanja zatvarača, ukoliko je zaštitni obruč za evidenciju otvaranja klimav, uklonite ga prije primjene lijeka.
English: 1, tinnitus
Croatian: 1, tinitus
English: SIMBRINZA should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans.
Croatian: SIMBRINZA se mora primijeniti s oprezom kod bolesnika s depresijom, cerebralnom ili koronarnom insuficijencijom, Raynaudovim fenomenom, ortostatskom hipotenzijom ili kod tromboangiitis obliteransa.
English: Table 1 Comparison of mean diurnal IOP (mmHg) change from baseline - Non-inferiority study
Croatian: Tablica 1 Promjena srednjeg dnevnog IOT-a (mm Hg) u odnosu na početni - Ispitivanje neinferiornosti
English: SIMBRINZA has a moderate influence on the ability to drive and use machines.
Croatian: SIMBRINZA umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: If you forget to use SIMBRINZA
Croatian: Ako ste zaboravili primijeniti SIMBRINZU
English: If you regularly consume alcohol, ask your doctor, optometrist (optician) or pharmacist for advice before taking this medicine.
Croatian: Ako redovno konzumirate alkohol, potražite savjet svog liječnika, optometrista (optičara) ili ljekarnika prije nego primijenite ovaj lijek.
English: It is not necessary to close and shake the bottle before you apply the drop in your other eye. Close the bottle cap firmly immediately after use.
Croatian: Nije potrebno zatvarati niti protresati bocu prije primjene kapi u drugo oko.
English: Clinical data on the use of SIMBRINZA adjunctive to prostaglandin analogues (PGA) also showed superior IOP-lowering efficacy of SIMBRINZA + PGA compared with the PGA alone.
Croatian: Klinički podaci o dodatnoj primjeni SIMBRINZE uz analoge prostaglandina (engl. prostaglandin analogues, PGA) također su pokazali superiornu učinkovitost SIMBRINZE + PGA na sniženje IOT-a u usporedbi sa samim PGA-om.
English: 2,abnormal sensation in eye
Croatian: 2, neuobičajen osjećaj u oku
English: The safety profile of SIMBRINZA in adjunct therapy was similar to that observed with SIMBRINZA monotherapy.
Croatian: Sigurnosni profil SIMBRINZE kao dodatne terapije bio je sličan onom zabilježenom kod monoterapije SIMBRINZOM.
English: - The other ingredients are benzalkonium chloride (see section 2 “Wearing contact lensesSIMBRINZA contains benzalkonium chloride”), propylene glycol, carbomer 974P, boric acid, mannitol, sodium chloride, tyloxapol, hydrochloric acid and/or sodium hydroxide and purified water.
Croatian: - Drugi sastojci su benzalkonijev klorid (pogledajte dio 2 „Nošenje kontaktnih lećaSIMBRINZA sadrži benzalkonijev klorid“), propilenglikol, karbomer 974P, boratna kiselina, manitol, natrijev klorid, tiloksapol, kloridna kiselina i/ili natrijev hidroksid i pročišćena voda.
English: Due to the brinzolamide component of SIMBRINZA, electrolyte imbalance, development of an acidotic state, and possible nervous system effects may occur.
Croatian: Zbog sastojka SIMBRINZE brinzolamida mogući su disbalans elektrolita, razvoj acidoze i učinci na središnji živčani sustav.
English: In humans, urinary brinzolamide and Ndesethylbrinzolamide accounted for about 60 and 6% of the dose, respectively.
Croatian: Kod ljudi, izmjereni brinzolamid i N-desetilbrinzolamid u urinu iznosio je oko 60%, odnosno 6% doze.
English: Gastrointestinal, nervous system, haematological, renal and metabolic effects are generally associated with systemic carbonic anhydrase inhibitors.
Croatian: Gastrointestinalni, hematološki i metabolički učinci, kao i učinci na živčani sustav i bubrege, općenito su povezani s inhibitorima karboanhidraze koji se daju sistemski.
English: If you stop using SIMBRINZA
Croatian: Ako prestanete primjenjivati SIMBRINZU
English: In rabbits oral, maternally toxic doses of brinzolamide of up to 6 mg/kg/day (261 times the recommended daily clinical dose of 23 µg/kg/day) revealed no effect on foetal development.
Croatian: Peroralne doze brinzolamida do 6 mg/kg/dan koje su iskazivale maternalnu toksičnost (261 puta veće od preporučene dnevne kliničke doze od 23 g/kg/dan), nisu utjecale na fetalni razvoj kunića.