FrancophonIA/ELRC3.0 huggingface dataset:
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines webportal.
Maltese: Ir-rekwiżiti tar-rapporti perjodiċi aġġornati dwar is-sigurtà għal dan il-prodott mediċinali huma mniżżla fil-lista tad-dati ta' referenza tal-Unjoni (lista EURD) prevista skont l-Artikolu 107c(7) tadDirettiva 2001/83/KE u kwalunke aġġornament sussegwenti ppubblikati fuq il-portal elettroniku Ewropew tal-mediċini.
English: The mean AUC and Cmax of the N-desmethyl metabolite increased up to 126% and up to 73% respectively, compared to age-matched volunteers with no renal impairment.
Maltese: Il-medja ta' l-AUC u Cmax tal-metabolu N-desmethyl żdiedu b'sa 126% u b'sa 73% rispettivament, mqabbla ma' voluntiera ta' listess età li ma kellhomx ħsara fil-kliewi.
English: Due to the nitrate component it has the potential to result in a serious interaction with sildenafil.
Maltese: Minħabba il-komponent ta' nitrate, hemm potenzjal li jirriżulta f'interazzjoni serja ma' sildenafil.
English: Do not take VIAGRA
Maltese: Tiħux VIAGRA
English: VIAGRA 25 mg tablets Blue, rounded diamond-shaped tablets, marked “PFIZER” on one side and “VGR 25” on the other.
Maltese: VIAGRA 25 mg pilloli Pilloli blu, ittundjati forma ta' djamant, immarkati “PFIZER” fuq naħa waħda u “VGR 25” fuq l-oħra.
English: Other medicines and VIAGRA
Maltese: Mediċini oħra u VIAGRA
English: Table 1: Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance
Maltese: Tabella 1: Reazzjonijiet avversi ta' importanza medika b'inċidenza ta' rapporti akbar minn plaċebo fi studji kliniċi kkontrollati, u reazzjonijiet avversi ta' importanza medika rrappurtati minn sorveljanza ta' wara t-tqegħid tal-prodott fis-suq
English: Co-administration of the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg twice daily) with sildenafil (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil Cmax and a 1,000% (11-fold) increase in sildenafil plasma AUC.
Maltese: Ko-amministrazzjoni ta' l-inibitur ta' HIV protease ritonavir, li huwa inibitur potenti ħafna tal-P450, fi stat stabbli (500 mg darbtejn kuljum) ma' sildenafil (100 mg doża waħda) irriżultat f'żieda ta' 300% (4 darbiet) fis-Cmax ta' sildenafil u żieda ta' 1000% (11-il darba) fl-AUC tal-plażma ta' sildenafil.
English: VIAGRA is a treatment for adult men with erectile dysfunction, sometimes known as impotence.
Maltese: VIAGRA hija kura għal irġiel adulti bi problema ta' erezzjoni tal-pene, kultant imsejħa impotenza.
English: Mean pulmonary systolic blood pressure decreased by 9%.
Maltese: Il-pressjoni medja sistolika tad-demm tal-pulmun naqset b'9%.
English: Children and adolescents VIAGRA should not be given to individuals under the age of 18.
Maltese: VIAGRA m'għandux jingħata lil individwi taħt l-età ta' 18-il sena.
English: In addition, N-desmethyl metabolite AUC and Cmax values were significantly increased by 200% and 79% respectively.
Maltese: Barra minn dan, il-valuri ta' l-AUC u s-Cmax tal-metabolite N-desmethyl żdiedu b'mod sinifikanti b'200% u 79% rispettivament.
English: PDE5 inhibitors, such as Viagra have been shown to increase the hypotensive effects of this medicine.
Maltese: Ġie muri li inibituri ta'PDE5, bħal Viagra,iżidu l-effetti ipotensivi ta' din il-mediċina.
English: Co-administration of the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state (1200 mg three times a day) with sildenafil (100 mg single dose) resulted in a 140% increase in sildenafil Cmax and a 210% increase in sildenafil AUC.
Maltese: Ko-amministrazzjoni ta' l-inibitur ta' HIV protease saquinavir, inibitur ta' CYP3A4, fi stat stabbli (1200 mg tlett darbiet kuljum) ma' sildenafil (100 mg doża waħda) irriżultat f'żieda ta' 140% fis-Cmax ta' sildenafil u żieda ta' 210% fl-AUC ta' sildenafil.
English: Each tablet contains sildenafil citrate equivalent to 25, 50 or 100 mg of sildenafil.
Maltese: Kull pillola fiha sildenafil citrate ekwivalenti għal 25, 50 jew 100 mg ta' sildenafil.
English: Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro.
Maltese: Studji bi plejtlets umani jindikaw li sildenafil isaħħaħ l-effett kontra l-aggregazzjoni ta' sodium nitroprusside in vitro .
English: VIAGRA 50 mg tablets Blue, rounded, diamond-shaped tablets, marked “PFIZER” on one side and “VGR 50” on the other.
Maltese: VIAGRA 50 mg pilloli Pilloli blu, ittundjati forma ta' djamant, immarkati “PFIZER” fuq naħa waħda u “VGR 50” fuq l-oħra.
English: At maximum recommended doses, there is an 80-fold selectivity over PDE1, and over 700-fold over PDE2, 3, 4, 7, 8, 9, 10 and 11.
Maltese: Bl-ogħla dożi rrakkomandati, hemm selettività ta' 80 darba fuq PDE1, u aktar minn 700 darba fuq PDE2, 3,4,7,8,9,10 u 11.
English: VIAGRA 25 mg film-coated tablets PVC/Aluminium blisters in cartons of 2, 4, 8 or 12 tablets.
Maltese: VIAGRA 25 mg pilloli miksija b'rita Folji ta' l-aluminju/PVC f'pakketti ta' 2, 4, 8 jew 12-il pillola.
English: After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range (25-100 mg).
Maltese: Wara doża orali ta' sildenafil l-AUC u Cmax jiżdiedu fi proporzjon maddoża fuq il-medda rrakkomandata tad-doża (25 -100 mg).
English: The mean maximum decreases in supine systolic blood pressure following 100 mg oral dosing of sildenafil was 8.4 mmHg.
Maltese: L-ogħla tnaqqis medju fil-pressjoni sistolika f'pożizzjoni mimduda wara 100 mg ta' sildenafil doża orali kien ta' 8.4 mmHg.
English: If you are taking riociguat.
Maltese: qed/a tieħu riociguat.
English: Pooling of the following classes of antihypertensive medication: diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products (vasodilator and centrally-acting), adrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment.
Maltese: Ġabra ta' dawn il-każi li ġejjin ta' medikazzjoni ta' kontra l-pressjoni għolja: dijuretiċi, beta-blokers, inibituri ta' ACE, antagonisti ta' angiotensin II, prodotti mediċinali kontra l-pressjoni għolja (vażodilataturi u li jaħdmu fuq is-sistema ċentrali), adrenergic neurone blockers, channel blockers talkalċju u blokers alpha-adrenoceptor, ma wrew ebda differenza fil-profil ta' effetti f'pazjenti li ħadu sildenafil mqabblin ma' kura bil-plaċebo.
English: VIAGRA potentiates the hypotensive effect of nitrates (see section 4.3).
Maltese: VIAGRA issaħħaħ l-effett ipotensiv tan-nitrati (ara sezzjoni 4.3).
English: Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.
Maltese: Dożi waħdiet orali ta' sildenafil sa 100 mg f'voluntiera b'saħħithom ma għamlu l-ebda effett klinikalment relevanti fuq l-ECG.
English: Gastro oesophagael reflux disease, Vomiting,
Maltese: Mard tar-rifluss gastroesofaġeali, Rimettar,
English: In the table below all medically important adverse reactions, which occurred in clinical trials at an incidence greater than placebo are listed by system organ class and frequency (very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000)..
Maltese: Fit-tabella ta' hawn taħt, ir-reazzjonijiet avversi ta' importanza medika, li seħħew fl-istudji kliniċi b'inċidenza ta' iktar minn bil-plaċebo, huma mniżżla skont il-klassi ta' l-organi u l-frekwenzi (komuni ħafna (≥1/10), komuni (≥1/100 sa <1/10), mhux komuni (≥1/1,000 sa <1/100), rari (≥1/10,000 sa <1/1,000).
English: Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM).
Maltese: Minħabba li sildenafil (u lmetabolu ewlenieni tiegħu N-desmethyl fiċ-ċirkolazzjoni) huwa 96% marbut ma' proteini tal-plażma, dan jirriżulta fl-ogħla konċentrazzjoni ta' plażma ħielsa għal sildenafil ta' 18 ng/ mL (38nM).
English: VIAGRA 100 mg tablets Sildenafil
Maltese: VIAGRA 100 mg pilloli
English: In a penile plethysmography (RigiScan) study of fasted patients, the median time to onset for those who obtained erections of 60% rigidity (sufficient for sexual intercourse) was 25 minutes (range 12-37 minutes) on sildenafil.
Maltese: Fi studju tal-pene bilpletismografu (RigiScan) f'pazjenti sajmin, il-ħin medjan biex jibdew l-erezzjonijiet għal dawk li kisbu 60% riġidità (suffiċjenti għal rapport sesswali) kien 25 minuta (medda bejn 12-37 minuta) b'sildenafil.
English: After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%).
Maltese: Wara doża orali waħda ta' 100 mg, l-ogħla konċentrazzjoni medja totali filplażma ta' sildenafil hija bejn wieħed u ieħor 440 ng/ml (CV 40%).
English: This is most likely to happen within 4 hours after taking VIAGRA.
Maltese: Normalment dan iseħħ liktar sa 4 sigħat wara li tittieħed VIAGRA.
English: When a single 100 mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg twice daily for 5 days), there was a 182% increase in sildenafil systemic exposure (AUC).
Maltese: Meta doża waħda ta' 100 mg sildenafil ġiet amministrata ma' erythromycin, inibitur moderat ta' CYP3A4, fi stat stabbli (500 mg darbtejn kuljum għal ħamest ijiem), kien hemm żieda ta' 182% fl-espożizzjoni sistemika (AUC) ta' sildenafil.
English: Sildenafil is an oral therapy for erectile dysfunction.
Maltese: Sildenafil huwa terapija orali għal problema ta' l-erezzjoni tal-pene.
English: In a study of the hemodynamic effects of a single oral 100 mg dose of sildenafil in 14 patients with severe coronary artery disease (CAD) (>70% stenosis of at least one coronary artery), the mean resting systolic and diastolic blood pressures decreased by 7% and 6% respectively compared to baseline.
Maltese: Fi studju ta' l-effetti imodinamiċi ta' doża waħda orali ta' 100 mg sildenafil f'14-il pazjenti b'mard sever ta' l-arterji tal-qalb (CAD) ( > 70% stenożi f'ta' mill-anqas arterja waħda tal-qalb), il-pressjoni medja sistolika u dijastolika tad-demm waqt is-serħan naqsu b'7% u 6% rispettivament mqabbla mallinja bażi.
English: Rare ( 1/10,000 and <1/1,000)
Maltese: Mhux komuni ( 1/1,000 u <1/100)
English: Sildenafil had no effect on ritonavir pharmacokinetics.
Maltese: Effetti ta' sildenafil fuq prodotti mediċinali oħra
English: Myocardial infarction, Ventricular arrhythmia*, Atrial fibrillation, Unstable angina
Maltese: Mewta kardijaka għallgħarrieda*, Infart mijokardijaku, Arritmja ventrikulari*, Fibrillazzjoni atrijali, Anġina instabbli
English: Consistent with its known effects on the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway (see section 5.1), sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitric oxide donors (such as amyl nitrite) or nitrates in any form is therefore contraindicated.
Maltese: Konsistenti ma' l-effetti magħrufa tiegħu fuq il-medda ta' nitric oxide / cyclic guanosine monophosphate (cGMP) (ara sezzjoni 5.1), sildenafil intwera li jsaħħaħ l-effetti ipotensivi tan-nitrati, u l-ko-amministrazzjoni tiegħu ma' donaturi ta' nitric oxide (bħal amyl nitrite) jew nitrati f'xi forma oħra hija għalhekk kontra-indikata.
English: Non-arteritic anterior ischaemic optic neuropathy (NAION) Retinal vascular occlusion*, Retinal haemorrhage, Arteriosclerotic retinopathy, Retinal disorder, Glaucoma, Visual field defect, Diplopia, Visual acuity reduced, Myopia, Asthenopia, Vitreous floaters, Iris disorder, Mydriasis, Halo vision, Eye oedema, Eye swelling, Eye disorder, Conjunctival hyperaemia, Eye irritation, Abnormal sensation in eye, Eyelid oedema, Scleral discoloration
Maltese: Newropatija anterjuri iskimika, mhux tal-arterja tal-għajn (NAION)*, Sadda fis-sistema vaskulari ġewwa r-retina*, Emorraġija retinali, Retinopatija arterjosklerotika, Disturb retinali, Glawkoma, Difett fil-kamp viżiv, Diplopja, Preċiżjoni viżiva mnaqqsa, Mijopija, Astenopja, Frak f'wiċċ illikwidu vitruż, Disturb fil-ħabba talgħajn, Mijadrijażi, Vista ta' awreola, Xantopsja, Eritropsja, Kloropsja, Edema tal-għajn, Nefħa tal-għajn, Disturbi fl-għajnejn, Iperemija tal- konġunktiva, Irritazzjoni tal-għajnejn, Sensazzjoni mhux normali fl-għajnejn, Edema fil-kappell talgħajn, Għajn xotta, Telf fil-kulur sklerali, Disturbi fid-dmugħ
English: When film-coated tablets are taken with food, the rate of absorption of sildenafil is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%.
Maltese: Meta sildenafil jittieħed ma' l-ikel, ir-rata ta' assorbiment titnaqqas b'dewmien medju fit-tmax ta' 60 minuta u tnaqqis medju fis-Cmax ta' 29%.
English: In volunteers with mild to moderate hepatic cirrhosis (Child-Pugh A and B) sildenafil clearance was reduced, resulting in increases in AUC (84%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment.
Maltese: F'voluntiera b'ċirrożi tal-fwied ħafifa għal moderata ( Child-Pugh A u B) it-tneħħija ta' sildenafil titnaqqas, u rriżulta f'żidiet fl-AUC (84%) u Cmax (47%) mqabbel ma' voluntiera ta' l-istess età li ma kellhomx ħsara fil-fwied.
English: Uncommon ( 1/1,000 and
Maltese: Mhux komuni ( 1/1.000 u <1/100)
English: The dosing recommendations described in ‘Use in adults' apply to patients with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min).
Maltese: Ir-rakkomandazzjonijiet ta' dożaġġi mfissra f' “Użu fl-adulti” japplikaw għal pazjenti b'indeboliment ħafif għal moderat tal-kliewi (tneħħija tal-creatinine = 30-80 mL/min).
English: PFIZER ΕΛΛΑΣ Α.Ε.
Maltese: Pfizer Europe MA EEIG
English: The physiological mechanism responsible for erection of the penis involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation.
Maltese: Il-mekkaniżmu fiżjoloġiku responsabbli għal erezzjoni tal-pene jinvolvi il-ħruġ ta' nitric oxide (NO) fil-corpus cavernosum waqt stimulazzjoni sesswali.
English: • Prolonged and sometimes painful erections - this occurs rarely (may affect up to 1 in 1,000 people)
Maltese: • Erezzjonijiet prolongati u kultant bl-uġieħ - dawn iseħħu b'mod rari (jistgħu jaffettwaw sa persuna 1 minn kull 1,000)
English: Vertigo, Tinnitus Deafness
Maltese: Epistassi, Konġestjoni tassinus
English: In a clinical study in 36 healthy males 45 years or older, 50 mg orodispersible tablets administered without water were observed to be bioequivalent to the 50 mg film-coated tablets.
Maltese: Fi studju kliniku f'36 raġel b'saħħithom li kellhom 45 sena jew aktar, il-pilloli li jinħallu fil-ħalq ta' 50 mg mogħtija mingħajr ilma ġew osservati li kienu bijoekwivalenti għall-pilloli miksija b'rita ta' 50 mg.
English: In volunteers with severe renal impairment (creatinine clearance <30 mL/min), sildenafil clearance was reduced, resulting in mean increases in AUC and Cmax of 100% and 88% respectively compared to age-matched volunteers with no renal impairment.
Maltese: F'voluntiera b'indeboliment sever tal-kliewi (tneħħija tal-creatinine < 30ml/min), it-tneħħija ta' sildenafil naqset, u wasslet għal żidiet medji ta' l-AUC u Cmax ta' 100% u 88% rispettivament mqabbla ma' voluntiera tal-istess età li ma kellhomx ħsara fil-kliewi.
English: 2 orodispersible tablets 4 orodispersible tablets 8 orodispersible tablets 12 orodispersible tablets
Maltese: 2 pilloli miksijin b'rita 4 pilloli miksijin b'rita 8 pilloli miksijin b'rita 12-il pillola miksijin b'rita
English: In the same study, the AUC was unchanged but the mean Cmax was 14% lower when 50 mg orodispersible tablets were administered with water compared to 50 mg film-coated tablet.
Maltese: Fl-istess studju, l-AUC baqgħet l-istess, iżda l-medja tas-Cmax kienet 14% iktar baxxa meta lpilloli li jinħallu fil-ħalq ta' 50 mg ingħataw mal-ilma meta mqabbla mal-pillola miksija b'rita ta' 50 mg.
English: In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n=9), sildenafil (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress).
Maltese: Fi studju żgħir ikkontrollat bilplaċebo ta' pazjenti b'deġenerazzjoni makulari bikrija dokumentata relatata ma' l-età (n=9), sildenafil (doża waħda, 100 mg) ma wera ebda tibdil sinifikanti fit-testijiet tal-vista li saru ( kemm tkun akuta lvista, Amsler grid, diskriminazzjoni ta' kulur ta' dwal tat-traffiku simulati, Humphrey perimeter u photostress).
English: Each tablet contains sildenafil citrate equivalent to 50 mg of sildenafil.
Maltese: Kull pillola fiha sildenafil citrate ekwivalenti għal 50 mg ta' sildenafil.
English: The tablets are provided in blister packs containing 2, 4, 8, 12 or 24 tablets in a carton or card packaging.
Maltese: Il-pilloli jiġu fi strixxi tal-fojl li fihom 2, 4, 8, 12 jew 24 pillola f'pakkett jew ipakkettar tal-kartun.
English: EU/1/98/077/015 (2 film-coated tablets) EU/1/98/077/010 (4 film-coated tablets) EU/1/98/077/011 (8 film-coated tablets) EU/1/98/077/012 (12 film-coated tablets) EU/1/98/077/025 (24 film-coated tablets)
Maltese: EU/1/98/077/015 (2 pilloli miksijin b'rita) EU/1/98/077/010 (4 pilloli miksijin b'rita) EU/1/98/077/011 (8 pilloli miksijin b'rita) EU/1/98/077/012 (12-il pillola miksijin b'rita) EU/1/98/077/025 (24 pillola miksijin b'rita)
English: The corresponding change in supine diastolic blood pressure was 5.5 mmHg.
Maltese: Il-bidla korrispondenti fil-pressjoni dijastolika f'pożizzjoni mimduda kienet 5.5 mmHg.
English: EU/1/98/077/016 (2 film-coated tablets) EU/1/98/077/017 (4 film-coated tablets) EU/1/98/077/018 (8 film-coated tablets) EU/1/98/077/019 (12 film-coated tablets)
Maltese: EU/1/98/077/016 (2 pilloli miksijin b'rita) EU/1/98/077/017 (4 pilloli miksijin b'rita) EU/1/98/077/018 (8 pilloli miksijin b'rita) EU/1/98/077/019 (12-il pillola miksijin b'rita)
English: In volunteers with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min), the pharmacokinetics of sildenafil were not altered after receiving a 50 mg single oral dose.
Maltese: F'voluntiera b'indeboliment ħafif għal moderat tal-kliewi (tneħħija tal-creatinine = 30-80ml/min), ilfarmakokinetika ta' sildenafil ma tbiddlitx wara doża orali waħda ta' 50 mg.
English: PVC/Aluminium blisters in cartons or secondary heat sealed card packaging of 2, 4, 8, 12 or 24 tablets.
Maltese: Folji ta' l-aluminju/PVC f'pakketti tal-kartun jew pakkett sekondarju ssiġillat bis-sħana, ta' 2, 4, 8, 12 jew 24 pillola.
English: EU/1/98/077/013 (2 film-coated tablets) EU/1/98/077/002 (4 film-coated tablets) EU/1/98/077/003 (8 film-coated tablets) EU/1/98/077/004 (12 film-coated tablets)
Maltese: EU/1/98/077/013 (2 pilloli miksijin b'rita) EU/1/98/077/002 (4 pilloli miksijin b'rita) EU/1/98/077/003 (8 pilloli miksijin b'rita) EU/1/98/077/004 (12-il pillola miksijin b'rita)
English: Your doctor may start you on a lower dose (25 mg film-coated tablets) of VIAGRA.
Maltese: Ittabib tiegħek jista' jibdik b'doża baxxa (25 mg pilloli miksija b'rita)) ta' VIAGRA.
English: Based on efficacy and tolerability, the dose may be increased to 100 mg.
Maltese: Bażata fuq effiċjenza u tollerabilità, id-doża tista' tiżdied għal 100 mg.
English: Each tablet contains sildenafil citrate equivalent to 25 mg of sildenafil
Maltese: Kull pillola fiha sildenafil citrate ekwivalenti għal 25mg ta' sildenafil
English: Your doctor may start you on a lower dose (25 mg) of VIAGRA.
Maltese: Ittabib tiegħek jista' jibdik b'doża baxxa ta' 25mg ta' VIAGRA.
English: oC.
Maltese: C.
English: The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: severe hepatic impairment, hypotension (blood pressure <90/50 mmHg), recent history of stroke or myocardial infarction and known hereditary degenerative retinal disorders such as retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases).
Maltese: Is-sigurtà ta' sildenafil ma ġietx studjata f'dawn is-sottogruppi ta' pazjenti li ġejjin, u għalhekk l-użu tiegħu huwa kontra-indikat: indeboliment sever tal-fwied, pressjoni baxxa (pressjoni tad-demm <90/50 mmHg), puplesija jew attakk tal-qalb reċenti u mard magħruf ereditarju ta' deġenerazzjoni tar-retina bħal retinitis pigmentosa (minoranza ta' dawn il-pazjenti għandhom mard ġenetiku ta' phosphodiesterases retinali).
English: These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle.
Maltese: Dan it-tnaqqis fil-pressjoni tad-demm huwa konsistenti ma' l-effetti ta' vażodilatazzjoni ta' sildenafil, probabbilment minħabba żieda fil-livelli ta' cGMP filmuskoli lixxi vaskulari.
English: Aluminium blisters in cartons of 2, 4, 8 or 12 tablets.
Maltese: Il-pilloli jiġu fi strixxi tal-fojl li fihom 2, 4, 8, 12 jew 24 pillola.
English: VIAGRA 50 mg orodispersible tablets Sildenafil
Maltese: VIAGRA 50 mg pilloli miksija b'rita Sildenafil
English: The total body clearance of sildenafil is 41 L/h with a resultant terminal phase half-life of 3-5 h. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the faeces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of administered oral dose).
Maltese: Wara jew amministrazzjoni orali jew fil-vina, sildenafil jitneħħa bħala metaboliti b'mod predominanti fl-ippurgar (bejn wieħed u ieħor 80% tad-doża orali amministrata) u f'proporzjon anqas fl-urina (bejn wieħed u ieħor 13% tad-doża orali mogħtija).
English: Blue, rounded, diamond-shaped tablets, marked “V50” on one side and plain on the other.
Maltese: Pilloli blu, ittundjati forma ta' djamant, immarkati “V50” fuq naħa waħda u xejn fuq l-oħra.
English: VIAGRA 100 mg tablets Blue, rounded diamond-shaped tablets, marked “PFIZER” on one side and “VGR 100” on the other.
Maltese: Pilloli blu, ittundjati forma ta' djamant, immarkati “PFIZER” fuq naħa waħda u “VGR 100” fuq loħra.
English: Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
Maltese: Nitric oxide imbagħad jattiva l-enżima guanylate cyclase, li tirriżulta f'livelli miżjuda ta' cyclic guanosine monophosphate (cGMP), li tipproduċi rilassament tal-muskoli lixxi fil-corpus cavernosum u tikkawża d-dħul tad-demm.
English: Non-arteritic anterior ischaemic optic neuropathy (NAION)*, Retinal vascular occlusion Retinal haemorrhage, Arteriosclerotic retinopathy, Retinal disorder, Glaucoma, Visual field defect, Diplopia, Visual acuity reduced, Myopia, Asthenopia, Vitreous floaters, Iris disorder, Mydriasis, Halo vision, Eye oedema, Eye swelling, Eye disorder, Conjunctival hyperaemia, Eye irritation, Abnormal sensation in eye, Eyelid oedema, Scleral discoloration
Maltese: Newropatija anterjuri iskimika, mhux tal-arterja tal-għajn (NAION)*, Sadda fis-sistema vaskulari ġewwa r-retina*, Emorraġija retinali, Retinopatija arterjosklerotika, Disturb retinali, Glawkoma, Difett fil-kamp viżiv, Diplopja,
English: When the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in increased corpus cavernosum levels of cGMP.
Maltese: Meta lpathway NO/cGMP tiġi attivata, bħalma jiġri bi stimulazzjoni sesswali, inibizzjoni ta' PDE5 minn sildenafil tirriżulta f'livelli aktar għoljin ta' cGMP fil-corpus cavernosum.
English: There was no effect on sperm motility or morphology after single 100 mg oral doses of sildenafil in healthy volunteers (see section 4.6).
Maltese: Ma kienx hemm effett fuq il-morfoloġija jew motilità ta' l-isperma wara dożi orali ta' 100 mg ilwaħda ta' sildenafil f'voluntiera b'saħħithom (ara sezzjoni 4.6).