FrancophonIA/ELRC3.0 huggingface dataset:
English: However, in an interaction study with healthy volunteers, entacapone did not change the plasma levels of S-warfarin, while the AUC for Rwarfarin increased on average by 18% [CI90 11-26%].
Slovenian: Vendar pa v raziskavi interakcij pri zdravih prostovoljcih entakapon ni povzročil spremembe plazemskih koncentracij S-varfarina, med tem, ko so se vrednosti AUC R-varfarina povečale v povprečju za 18 % [CI90 11-26 %].
English: This may hasten the elimination of entacapone in particular by decreasing its absorption/reabsorption from the GI tract.
Slovenian: To lahko pospeši odstranjevanje entakapona s tem, da zmanjšuje njegovo absorpcijo/resorpcijo iz prebavnega trakta.
English: - Patients should be regularly monitored for the development of impulse control disorders.
Slovenian: - Bolnike je treba redno spremljati zaradi možnosti razvoja motenj pri obvladovanju impulzov.
English: Pharmacotherapeutic group: anti-parkinson drugs, dopa and dopa derivatives, ATC code: N04BA03
Slovenian: Farmakoterapevtska skupina: antiparkinsonik, dopa in derivati dope, oznaka ATC: N04BA03
English: No pharmacodynamic interactions were observed.
Slovenian: Farmakodinamičnih interakcij niso opazili.
English: Food does not significantly affect the absorption of entacapone.
Slovenian: Hrana bistveno ne vpliva na absorpcijo entakapona.
English: The value of dialysis in the treatment of overdose is not known.
Slovenian: Koristnost dialize pri zdravljenju prevelikega odmerjanja ni znana.
English: If it is more than 1 hour until your next dose: Take one tablet as soon as you remember, and the next tablet at the normal time.
Slovenian: Če je do naslednjega odmerka več kot 1 uro časa: vzemite eno tableto takoj, ko se spomnite, drugo pa ob normalnem času za odmerek.
English: even if their symptoms signs of illness are the same as yours.
Slovenian: Njim bi lahko celo škodovalo, čeprav imajo znake bolezni, podobne vašim.
English: Both levodopa and entacapone are rapidly absorbed and eliminated.
Slovenian: Tako levodopa kot entakapon se hitro absorbirata in izločata.
English: PC: {number} SN: {number} < NN: {number} >
Slovenian: PC: {številka} SN: {številka} < NN: {številka}>
English: For severe hepatic impairment see section 4.3.
Slovenian: Za hudo okvaro jeter glejte poglavje 4.3.
English: See section c.
Slovenian: Glejte poglavje c.
English: The optimum daily dose must be determined by careful titration of levodopa in each patient.
Slovenian: Optimalni dnevni odmerek je treba določiti s pomočjo skrbne titracije levodope pri vsakem posameznem bolniku.
English: The use of glucose oxidase methods may give false negative results for glycosuria.
Slovenian: Uporaba metod z glukoza-oksidazo lahko povzroči lažno negativne rezultate za glikozurijo.
English: Consequently the clinical response to each dose of levodopa is enhanced and prolonged.
Slovenian: Skladno s tem je klinični odgovor na vsak posamezni odmerek levodope močnejši in dolgotrajnejši.
English: Patients receiving less than 70-100 mg carbidopa a day are more likely to experience nausea and vomiting.
Slovenian: Pri bolnikih, ki dobivajo manj kot 70-100 mg karbidope dnevno, obstaja večja verjetnost pojava slabosti in bruhanja.
English: Levodopa is bound to plasma protein only to a minor extent of about 10-30% and carbidopa is bound approximately 36%, while entacapone is extensively bound to plasma proteins (about 98%) -mainly to serum albumin.
Slovenian: Levodopa se le v manjši meri veže na proteine v plazmi (približno 10-30 %), karbidopa pa v približno 36 %, med tem ko se entakapon veže na proteine v plazmi v veliki meri (približno 98 %) - pretežno na serumski albumin.
English: The adequacy of the respiratory, circulatory and renal systems should be carefully monitored and appropriate supportive measures employed.
Slovenian: Ustreznost delovanja dihal, krvnega obtoka in ledvic je treba skrbno nadzorovati in po potrebi uvesti odgovarjajoče podporne ukrepe.
English: Orthostatic hypotension, hypertension
Slovenian: ortostatska hipotenzija, hipertenzija
English: The SmPC section 4.4 and 4.8 are being updated to add Dopamine Dysregulation Syndrome (DDS) with a frequency “not known” and to add further explanation with regards to DDS to section 4.8 to increase awareness and understanding on the pathology and add a warning to section 4.4 to recommend relevant precautions.
Slovenian: Poglavji 4.4 in 4.8 SmPC-ja sta bili posodobljeni, dodan je bil sindrom motene regulacije dopamina (DDS) s pogostnostjo »ni znano«; v poglavje 4.8 je bila dodana dodatna obrazložitev glede sindroma motene regulacije dopamina z namenom povečanja ozaveščenosti in razumevanja patologije ter dodano opozorilo v poglavje 4.4 s priporočilom posebnih previdnostnih ukrepov.
English: Suicidal behaviour, Dopamine dysregulation syndrome
Slovenian: samomorilno vedenje, sindrom motene regulacije dopamina
English: - For patients who experience progressive anorexia, asthenia and weight decrease within a relatively short period of time, a general medical evaluation including liver function should be considered.
Slovenian: - Za bolnike, ki izkusijo progresivno anoreksijo, astenijo ali zmanjšanje telesne mase v relativno kratkem obdobju je treba razmisliti o splošnem zdravniškem pregledu, vključno z delovanjem jeter.
English: In such a case your doctor may need to adjust your other antiparkinson medicines, especially levodopa, to give sufficient control of your symptoms.
Slovenian: V takem primeru bo morda vaš zdravnik moral prilagoditi odmerjanje drugih antiparkinsonskih zdravil, ki jih jemljete, zlasti levodope, za zadovoljivo obvladovanje vaših simptomov.
English: Consult your doctor if you are currently taking: - antipsychotics (medicines used to treat psychosis) - a medicine which may cause low blood pressure when rising from a chair or bed.
Slovenian: Posvetujte se z zdravnikom, če trenutno jemljete: - antipsihotike (zdravila, ki se uporabljajo za zdravljenje psihoze); - zdravila, zaradi katerih se vam lahko pri vstajanju s stola ali postelje zniža krvni tlak.
English: If required, appropriate anti-arrhythmic therapy should be given.
Slovenian: Po potrebi je treba uvesti zdravljenje z ustreznimi antiaritmiki.
English: Adverse reactions are ranked under headings of frequency, the most frequent first, using the following convention: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data, since no valid estimate can be derived from clinical trials or epidemiological studies).
Slovenian: V razvrstitvah pogostnosti so neželeni učinki navedeni po padajoči resnosti po naslednjem dogovoru: Zelo pogosti (≥ 1/10); pogosti (≥ 1/100 do < 1/10); občasni (≥ 1/1.000 do < 1/100); redki (≥ 1/10.000 do < 1/1.000); zelo redki (< 1/10.000), neznani (ni jih možno oceniti z razpoložljivimi podatki, saj ustrezna ocena iz kliničnih preskušanj ali epidemioloških študij ni mogoča).
English: One tablet contains one treatment dose and the tablet may only be administered as whole tablets.
Slovenian: Ena tableta vsebuje enkratni terapevtski odmerek, tablete pa se smejo jemati le cele.
English: Unchanged carbidopa accounts for 30% of the total urinary excretion.
Slovenian: Karbidopa v nespremenjeni obliki predstavlja 30 % vseh oblik, ki se izločajo v urinu.
English: Carbidopa and entacapone were excreted in milk in animals but is not known whether they are excreted in human breast milk.
Slovenian: Karbidopa in entakapon sta se izločala v mleku živali, ni pa znano, ali se izločata tudi v materino mleko.
English: **The incidence rates of myocardial infarction and other ischemic heart disease events (0.43% and 1.54%, respectively) are derived from an analysis of 13 double-blind studies involving 2082 patients with end-of-dose motor fluctuations receiving entacapone.
Slovenian: **Stopnja incidence miokardnega infarkta in drugih dogodkov ishemičnih srčnih bolezni (0,43 % in 1,54 %) so izpeljani iz analize 13 dvojno slepih študij, ki so zajemale 2.082 bolnikov z motorno fluktuacijo ob koncu odmerjanja ob prejemanju entakapona.
English: Entacapone is almost completely metabolized prior to excretion via urine (10 to 20%) and bile/faeces (80 to 90%).
Slovenian: Entakapon se skoraj v celoti presnovi, preden se izloči z urinom (10-20 %) in preko žolča/blata (8090 %).
English: Since the introduction of entacapone into the market, isolated cases of NMS have been reported, especially following abrupt reduction or discontinuation of entacapone and other concomitant dopaminergic medicinal products.
Slovenian: Od uvedbe entakapona na tržišče poročajo o posameznih primerih NMS, zlasti po nenadnem zmanjšanju ali ukinitvi entakapona in drugih sočasnih dopaminergičnih zdravil.
English: The main metabolic pathway is glucuronidation of entacapone and its active metabolite, the cis-isomer, which accounts for about 5% of plasma total amount.
Slovenian: Glavna presnovna pot je glukuronizacija entakapona in njegovega aktivnega presnovka cisizomera, ki predstavlja približno 5 % celotne količine v plazmi.
English: Parkinson's disease is caused by low levels of a substance called dopamine in the brain.
Slovenian: Parkinsonovo bolezen povzročajo nizke ravni snovi, ki se imenuje dopamin, v možganih.
English: The Package leaflet is updated accordingly.
Slovenian: Navodilo za uporabo je bilo ustrezno posodobljeno.
English: ECG monitoring should be started and the patient carefully monitored for the possible development of arrhythmias.
Slovenian: Uvesti je treba tudi nadzor z EKG in bolnika skrbno spremljati zaradi morebitnega pojava aritmij.
English: If any of this happens, contact your doctor immediately - feel depressed, have suicidal thoughts, or notice unusual changes in your behaviour - find yourself suddenly falling asleep, or if you feel very drowsy.
Slovenian: Če opazite karkoli od zgoraj navedenega, se takoj posvetujte s svojim zdravnikom; - počutite depresivne, imate samomorilne misli ali opazite nenavadne spremembe v svojem vedenju; - nenadoma zaspite ali se počutite zelo zaspani.
English: In the second study, the mean proportion of daily ON time increased by 4.5% (CI95% 0.93%, 7.97%) from baseline.
Slovenian: V drugi raziskavi se je srednje razmerje dnevnega trajanja intervala »ON« povečalo za 4,5 % (CI95% 0,93 %, 7,97 %) glede na izhodiščne vrednosti.
English: Contains sucrose.
Slovenian: Vsebuje saharozo.
English: Elderly: When given without carbidopa and entacapone, the absorption of levodopa is greater and elimination is slower in elderly than in young people.
Slovenian: Starejši: Kadar se levodopa daje brez karbidope in entakapona, je pri starejših njena absorpcija večja, izločanje pa počasnejše kot pri mlajših osebah.
English: Levodopa increases the amount of dopamine and hence reduces the symptoms of Parkinson's disease.
Slovenian: Levodopa povečuje količino dopamina in tako zmanjša simptome Parkinsonove bolezni.
English: Therefore, caution should be exercised when driving or using machines.
Slovenian: Zato je pri vožnji in upravljanju strojev potrebna previdnost.
English: Weight decreased*, decreased appetite*
Slovenian: zmanjšanje telesne mase*, zmanjšanje apetita*
English: If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je vaš zdravnik povedal, da ne prenašate nekaterih vrst sladkorja, se posvetujte z njim, preden začnete jemati to zdravilo.
English: In vitro data: Entacapone binds to human albumin binding site II which also binds several other medicinal products, including diazepam and ibuprofen.
Slovenian: Podatki in vitro: Entakapon se veže na vezavno mesto II v humanem albuminu, kamor se vežejo še mnoga druga zdravila, vključno z diazepamom in ibuprofenom.
English: Prolonged or persistent diarrhoea appearing during use of entacapone may be a sign of colitis.
Slovenian: Dolgotrajna ali trdovratna diareja, do katere pride med uporabo entakapona, je lahko znak kolitisa.
English: Gender: Bioavailability of levodopa is significantly higher in women than in men.
Slovenian: Spol: Biološka uporabnost levodope je pri ženskah značilno višja kot pri moških.
English: The daily dose of levodopa can be reduced by extending the dosing intervals and/or by reducing the amount of levodopa per dose, according to the clinical condition of the patient.
Slovenian: Dnevni odmerek levodope se lahko zmanjša s podaljšanjem odmernega obdobja in/ali z zmanjšanjem količine levodope na odmerek, glede na klinično stanje bolnika.
English: Entacapone in high doses may affect the absorption of carbidopa.
Slovenian: Visoki odmerki entakapona lahko vplivajo na absorpcijo karbidope.
English: Interactions between entacapone and imipramine and between entacapone and moclobemide have been investigated in single dose studies in healthy volunteers.
Slovenian: Interakcije med entakaponom in imipraminom ter med entakaponom in moklobemidom so proučevali v raziskavah z enkratnimi odmerki pri zdravih prostovoljcih.
English: For some patients, Levodopa/Carbidopa/Entacapone Orion may not be well absorbed if it is taken with, or shortly after eating protein-rich food (such as meats, fish, dairy products, seeds and nuts).
Slovenian: Pri nekaterih bolnikih se zdravilo Levodopa/Carbidopa/Entacapone Orion ne absorbira tako dobro, če ga jemljejo med obrokom ali kmalu po obroku proteinsko bogate hrane (npr. meso, ribe, mlečni izdelki, semena in oreški).
English: - Allergic reaction, the signs may include hives (nettle rash), itching, rash, swelling of your face, lips, tongue or throat.
Slovenian: - Alergijske reakcije, znaki so lahko osip (koprivnica), srbenje, izpuščaj, oteklost obraza, ustnic, jezika ali grla.
English: Meals rich in large neutral amino acids may delay and reduce the absorption of levodopa.
Slovenian: Obroki, ki vsebujejo veliko nevtralnih aminokislin, lahko upočasnijo ali zmanjšajo absorpcijo levodope.
English: time with and without entacapone was recorded in home-diaries by patients.
Slovenian: Dnevni interval učinkovanja zdravila z ali brez entakapona so bolniki beležili v domači dnevnik.
English: Tell your doctor if you or your family/carer notices you are developing urges or cravings to behave in ways that are unusual for you or you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others.
Slovenian: Zdravniku povejte, če sami ali kdo v vaši družini ali vaš skrbnik opazi za vas neobičajno vedenje, da čutite neustavljivo željo ali potrebo po izvajanju določenih dejanj in se ne morete upirati nagibom, željam ali skušnjavam, da bi izvajali določene dejavnosti, ki so lahko škodljive za vas ali druge.
English: Studies in animals have shown reproductive toxicity of the separate compounds (see section 5.3).
Slovenian: Študije na živalih so pokazale vpliv posameznih učinkovin na sposobnost razmnoževanja (glejte poglavje 5.3).
English: However, after combination of carbidopa with levodopa, the absorption of levodopa is similar between the elderly and the young people, but the AUC is still 1.5 fold greater in the elderly due to decreased DDC activity and lower clearance by aging.
Slovenian: Vendar pa je pri kombinaciji karbidope z levodopo absorpcija levodope pri starejših in pri mlajših podobna, med tem ko je vrednost AUC pri starejših še vedno 1,5-krat večja zaradi starostno pogojenega zmanjšanega delovanja DDK in nižjega očistka.
English: Absorption/distribution: There are substantial inter- and intra-individual variations in the absorption of levodopa, carbidopa and entacapone.
Slovenian: Absorpcija/porazdelitev: Obstajajo znatne interindividualne in intraindividualne razlike v absorpciji levodope, karbidope in entakapona.
English: In the first study, entacapone increased the mean daily ON time by 1 h 20 min (CI 95% 45 min, 1 h 56 min) from baseline.
Slovenian: V prvi raziskavi je entakapon povečal dnevno trajanje intervala učinkovanja (»ON«) za 1 h 20 min (CI95% 45 min, 1 h 56 min) glede na izhodiščne vrednosti.
English: HDPE bottle with a child resistant PP-closure.
Slovenian: Stekleničke iz HDPE z za otroke varnim polipropilenskim zamaškom.
English: Other active substances: Dopamine receptor antagonists (e.g. some antipsychotics and antiemetics), phenytoin and papaverine may reduce the therapeutic effect of levodopa.
Slovenian: Druge učinkovine: Antagonisti dopaminskih receptorjev (npr. nekateri antipsihotiki in antiemetiki), fenitoin in papaverin lahko zmanjšajo terapevtski učinek levodope.
English: - Concomitant administration of antipsychotics with dopamine receptor-blocking properties, particularly D2 receptor antagonists should be carried out with caution, and the patient carefully observed for loss of antiparkinsonian effect or worsening of parkinsonian symptoms.
Slovenian: - Sočasno dajanje antipsihotikov, ki delujejo kot zaviralci dopaminskih receptorjev, zlasti pa antagonistov receptorjev D2, zahteva previdnost, bolnika pa je treba skrbno spremljati, če bi prišlo do izgube antiparkinsonskega učinka ali poslabšanja parkinsonskih simptomov.
English: Entacapone may in some cases cause also discolouration of e.g. skin, nail, hair and sweat.
Slovenian: V nekaterih primerih povzroči entakapon tudi obarvanje npr. kože, nohtov, las in znoja.
English: Data from in vitro studies using human liver microsomal preparations indicate that entacapone inhibits cytochrome P450 2C9 (IC50 ~ 4 µM).
Slovenian: Podatki raziskav in vitro, v katerih so uporabili mikrosomske preparate iz človeških jeter kažejo, da entakapon zavira citokrom P450 2C9 (IC50 ~ 4 µM).
English: Discolourations other than urine (e.g. skin, nail, hair, sweat)*
Slovenian: obarvanje, razen urina (npr. kože, nohtov, las, znoja)*
English: Gastrointestinal haemorrhage
Slovenian: gastrointestinalna krvavitev
English: Carbidopa is metabolized to two main metabolites which are excreted in the urine as glucuronides and unconjugated compounds.
Slovenian: Karbidopa se presnavlja v dva glavna presnovka, ki se izločata v urinu v obliki glukoronida in nekonjugiranih spojin.
English: However, caution should be exercised when these medicinal products are used concomitantly with Levodopa/Carbidopa/Entacapone Orion (see sections 4.3 and 4.4).
Slovenian: Vseeno pa je potrebna previdnost, kadar se ta zdravila uporabljajo sočasno z zdravilom Levodopa/Carbidopa/Entacapone Orion (glejte poglavji 4.3 in 4.4).
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Slovenian: DATUM PRVE PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: Renal impairment: Renal impairment does not affect the pharmacokinetics of entacapone.
Slovenian: Okvara ledvic: Okvara ledvic ne vpliva na farmakokinetiko entakapona.
English: Urinary retention
Slovenian: zastajanje urina
English: Correspondingly, the daily OFF time decreased by 18% on entacapone and by 5% on placebo.
Slovenian: Skladno s tem se je dnevno trajanje intervala »OFF« pri skupini z entakaponom skrajšalo za 18 %, pri skupini s placebom pa za 5 %.
English: Dopamine dysregulation syndrome is mentioned in the product information of other dopaminergic medication used in Parkinson's disease such as levodopa/carbidopa, apomorphine, levodopa/benserazide, rotigotine and ropinirole.
Slovenian: Sindrom motene regulacije dopamina je omenjen v informacijah o zdravilu pri drugih dopaminergičnih zdravilih, ki se uporabljajo pri zdravljenju Parkinsonovi bolezni, kot so levodopa/karbidopa, apomorfin, levodopa/benserazid, rotigotin in ropinirol.
English: Rash*, hyperhidrosis
Slovenian: izpuščaj*, hiperhidroza
English: Dose adjustment of the antihypertensive agent may be required.
Slovenian: Morda bo potrebno prilagoditi odmerek antihipertenziva.
English: The distribution volume of both levodopa (Vd 0.36-1.6 l/kg) and entacapone (Vdss 0.27 l/kg) is moderately small while no data for carbidopa are available.
Slovenian: Volumen porazdelitve tako levodope (Vd 0,36 - 1,6 l/kg) kot entakapona (Vdss 0,27 l/kg) je zmerno majhen, medtem ko za karbidopo ni podatkov.
English: Carbidopa and benserazide are peripheral DDC inhibitors which reduce the peripheral metabolism of levodopa to dopamine, and thus, more levodopa is available to the brain.
Slovenian: Karbidopa in benzerazid so periferni zaviralci DDK, ki zmanjšujejo periferno presnovo levodope v dopamin, zaradi česar je večja količina levodope na razpolago v možganih.
English: According to the current understanding, the symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum.
Slovenian: V skladu z dosedanjimi ugotovitvami so simptomi Parkinsonove bolezni povezani z izgubo dopamina v progastem telesu (corpus striatum).
English: Muscle, musculoskeletal and connective tissue pain*
Slovenian: bolečina mišic, mišično-skeletna bolečina in bolečina vezivnega tkiva*
English: Entacapone is a reversible, specific and mainly peripherally acting COMT inhibitor designed for concomitant administration with levodopa.
Slovenian: Entakapon je reverzibilen, specifičen in pretežno periferno delujoč zaviralec COMT, ki je namenjen sočasni uporabi z levodopo.
English: The following side effects have also been reported: - hepatitis (inflammation of the liver) - itching
Slovenian: Poročali so tudi o naslednjih neželenih učinkih: - hepatitis (vnetje jeter) - srbenje
English: These behaviours are called impulse control disorders and can include addictive gambling, excessive eating or spending, an abnormally high sex drive or a preoccupation with an increase in sexual thoughts or feelings.
Slovenian: Tako vedenje imenujemo motnje pri obvladovanju impulzov in lahko vključuje odvisnost od iger na srečo, prenajedanje ali prekomerno zapravljanje denarja, nenormalno povečano spolno slo ali obsedenost s pretiranim predajanjem mislim ali občutkom v povezavi s spolnostjo.
English: 4.8 Undesirable effects a.
Slovenian: 4.8 Neželeni učinki a. Povzetek varnostnih lastnosti zdravila
English: Depression, hallucination, confusional state*, abnormal dreams*, anxiety, insomnia
Slovenian: depresija, halucinacije, stanje zmedenosti*, nenormalne sanje*, anksioznost, nespečnost
English: Myocardial infarction**
Slovenian: miokardni infarkt**
English: At therapeutic concentrations, entacapone does not displace other extensively bound active substances (e.g. warfarin, salicylic acid, phenylbutazone, or diazepam), nor is it displaced to any significant extent by any of these substances at therapeutic or higher concentrations.
Slovenian: V terapevtskih koncentracijah entakapon ne izpodriva drugih učinkovin, ki se vežejo v velikem odstotku (npr. varfarin, salicilna kislina, fenilbutazon ali diazepam), niti ga nobena od teh učinkovin v terapevtskih ali tudi višjih koncentracijah bistveno ne izpodriva.
English: Entacapone slows the clearance of levodopa from the bloodstream resulting in an increased area under the curve (AUC) in the pharmacokinetic profile of levodopa.
Slovenian: Entakapon upočasni izločanje levodope iz krvnega obtoka, kar ima v farmakokinetičnem profilu levodope za posledico povečano površino pod krivuljo (AUC).
English: Do not take Levodopa/Carbidopa/Entacapone Orion if you are taking certain medicines for treating depression (combinations of selective MAO-A and MAO-B inhibitors, or non-selective MAO inhibitors).
Slovenian: Ne uporabljajte zdravila Levodopa/Carbidopa/Entacapone Orion, če jemljete nekatera zdravila za zdravljenje depresije (kombinacija selektivnih zaviralcev MAO-A in MAO-B ali neselektivnih zaviralcev MAO).
English: These can be symptoms of neuroleptic malignant syndrome (NMS, a rare severe reaction to medicines used to treat disorders of the central nervous system) or rhabdomyolysis (a rare severe muscle disorder).
Slovenian: To so lahko simptomi nevroleptičnega malignega sindroma (NMS, zelo redka huda reakcija na zdravila, ki se uporabljajo za zdravljenje bolezni osrednjega živčnega sistema) ali rabdomiolize (redka huda bolezen mišic).
English: Some of these adverse reactions relate to the increased dopaminergic activity (e.g. dyskinesia, nausea and vomiting) and occur most commonly at the beginning of the treatment.
Slovenian: Nekateri od teh neželenih učinkov so povezani z večjo dopaminergično aktivnostjo (npr. diskinezija, navzea in bruhanje) in se pogosto pojavijo ob začetku zdravljenja.