FrancophonIA/ELRC3.0 huggingface dataset:
English: Both dextromethorphan and memantine are antagonists of the N-methyl-D-aspartate (NMDA) receptor which could theoretically result in an additive effect at NMDA receptors and potentially an increased incidence of adverse reactions.
Croatian: I dekstrometorfan i memantin antagonisti su N-metil-D-aspartatnih (NMDA) receptora, što bi teoretski moglo rezultirati aditivnim učinkom na NMDA receptore i potencijalno povećanom incidencijom nuspojava.
English: Other P-gp substrates for which a dose reduction may be considered include ticagrelor and dabigatran-etexilate.
Croatian: Ostali supstrati P-glikoproteina, za koje se može uzeti u obzir smanjenje doze, uključuju tikagrelor i dabigatraneteksilat.
English: Only for NUEDEXTA 15 mg/9 mg: Blister packs consist of a PVC based clear film with aluminium foil seal and contains 13 hard capsules.
Croatian: Samo za lijek NUEDEXTA 15 mg/9 mg: Pakiranje blistera sastoji se od prozirnog filma na PVC podlozi zatvorenog aluminijskom folijom, a sadrži 13 tvrdih kapsula.
English: • if you have a history of a condition called lupus-like syndrome caused by quinidine (this can cause joint pains, skin rash, excessive skin sensitivity to sun and overall feeling of sickness).
Croatian: • ako ste u prošlosti imali bolest koja se naziva sindrom nalik lupusu prouzročenu kinidinom (to može izazvati bolove u zglobovima, osip na koži, pretjeranu osjetljivost kože na sunce i sveukupni osjećaj bolesti).
English: Take care if you consume alcohol while you are taking NUEDEXTA as might increase the risk of side effects such as dizziness and sleepiness.
Croatian: Pazite ako konzumirate alkohol dok uzimate lijek NUEDEXTA, jer to može povećati rizik od nuspojava kao što su omaglica i pospanost.
English: Efficacy has only been studied in patients with underlying Amyotrophic Lateral Sclerosis or Multiple Sclerosis (see section 5.1).
Croatian: Djelotvornost je ispitana samo u bolesnika u kojih su temeljne bolesti bile amiotrofna lateralna skleroza ili multipla skleroza (vidjeti dio 5.1).
English: • if you are taking, or have taken during the last two weeks, certain medicines for depression called monoamine oxidase inhibitors (MAOIs), such as phenelzine and moclobemide.
Croatian: • ako uzimate ili ste uzimali tijekom protekla dva tjedna određene lijekove protiv depresije, koji se nazivaju inhibitori monoaminoksidaze, kao što su fenelzin i moklobemid.
English: Through its binding to the NMDA, sigma-1, SERT and 5-HT1B/D receptors, dextromethorphan is thought to have a modulatory effect on neurotransmission involving glutamate, monoamines (including serotonin), as well as ion channel function.
Croatian: Smatra se da dekstrometorfan svojim vezanjem na receptore NMDA, sigma-1, SERT i 5-HT1B/D ima modulacijski učinak na neurotransmisiju, uključujući glutamat, monoamine (uključujući serotonin), a također i na funkciju ionskih kanala.
English: Quinidine plasma concentrations are proportional to quinidine dose.
Croatian: Koncentracije kinidina u plazmi proporcionalne su dozi kinidina.
English: The maximum daily dose from week 4 onwards is NUEDEXTA 23 mg/9 mg, twice daily.
Croatian: Maksimalna dnevna doza od 4. tjedna nadalje je NUEDEXTA 23 mg/9 mg, dvaput na dan.
English: It should not be used if immunemediated thrombocytopenia from structurally related active substances including quinine and mefloquine is suspected, as cross-sensitivity can occur.
Croatian: Lijek se ne smije uzimati ako postoji sumnja na imunološki posredovanu trombocitopeniju, izazvanu strukturno povezanim djelatnim tvarima uključujući kinin i meflokin, jer bi moglo doći do ukrižene osjetljivosti.
English: Each bottle consists of high density polyethylene (HDPE) with a child resistant polypropylene cap and contains 60 hard capsules.
Croatian: Svaka bočica izrađena je od polietilena visoke gustoće (HDPE) s polipropilenskim sigurnosnim zatvaračem za djecu, a sadrži 60 tvrdih kapsula.
English: Lactose warning
Croatian: Upozorenje na laktozu
English: No other drug interactions with CYP2D6 substrates have been systematically investigated.
Croatian: Druge interakcije lijekova sa supstratima CYP2D6 nisu sistematski ispitivane.
English: While therapeutic doses of quinidine for treatment of cardiac arrhythmia or malaria are generally ≥10fold higher than the dose of quinidine in this medicinal product, potentially fatal cardiac arrhythmia, including torsades de pointes, can occur at quinidine exposures that are possible from NUEDEXTA overdose.
Croatian: Dok su terapijske doze kinidina za liječenje srčanih aritmija ili malarije uglavnom ≥10 puta više od doze kinidina u ovom lijeku, potencijalno fatalne srčane aritmije, uključujući torsades de pointes, mogu se razviti pri izloženosti kinidinu kakvo je moguće u slučaju predoziranja NUEDEXTOM.
English: The effect of the combination on the patient's QTc interval should be evaluated with pre- and post-dose ECGs.
Croatian: Učinak kombinacije na QTc interval u bolesnika je potrebno procijeniti EKG-om prije i poslije primjene doze.
English: The quinidine in NUEDEXTA inhibits CYP2D6 in patients in whom CYP2D6 is not otherwise genetically absent or of low activity (“CYP2D6 Poor Metabolisers” see “Pharmacogenomics” in section 5.2).
Croatian: Kinidin u lijeku NUEDEXTA inhibira CYP2D6 u bolesnika u kojih CYP2D6 inače nije genetski odsutan ili je slabo aktivan („slabi metabolizatori CYP2D6“ vidjeti „Farmakogenomika“ u dijelu 5.2).
English: • St John's wort, a herbal medicine used to treat depression
Croatian: • gospina trava, biljni lijek koji se koristi za liječenje depresije
English: However, as there was a trend toward increased incidence of adverse reactions in patients with moderate hepatic impairment, additional monitoring of adverse reactions is advised in these patients.
Croatian: Međutim, s obzirom da je postojao trend prema povećanoj incidenciji nuspojava u bolesnika s umjerenim oštećenjem funkcije jetre, u tih se bolesnika savjetuje dodatni nadzor zbog mogućih nuspojava.
English: The higher dose of quinidine used in these studies would have resulted in approximately a 1.6 fold greater exposure to of dextromethorphan than with NUEDEXTA 23 mg/ 9 mg.
Croatian: Viša doza kinidina primijenjena u tim ispitivanjima rezultirala bi približno 1,6 puta većom izloženošću dekstrometorfanu nego uz lijek NUEDEXTA 23 mg/9 mg.
English: Patients with complete atrioventricular (AV) block without implanted pacemakers, or in patients who are at high risk of complete AV block (see section 4.4).
Croatian: Bolesnici s potpunim atrioventrikularnim (AV) blokom bez ugrađenih električnih stimulatora srca (pejsmejkera) ili bolesnici u kojih postoji visoki rizik od potpunog atrioventrikularnog bloka (vidjeti dio 4.4).
English: In such UM patients, dextromethorphan is rapidly metabolised, leading to lower, potentially subtherapeutic concentrations.
Croatian: U takvih bolesnika određenih kao ultra brzi metabolizatori, dekstrometorfan se brzo metabolizira što dovodi do nižih, potencijalno subterapijskih koncentracija.
English: The supratherapeutic doses are adequate to represent quinidine exposure increases due to drug-drug interactions and organ dysfunctions.
Croatian: Supraterapijske doze odgovarajuće su pokazale povećanja izloženosti kinidinu zbog interakcija lijekova i disfunkcija organa.
English: LVH and LVD are more likely to be present in patients with chronic hypertension, known coronary artery disease or history of stroke.
Croatian: Prisutnost LVH i LVD vjerojatnija je u bolesnika s kroničnom hipertenzijom, potvrđenom bolešću koronarnih arterija ili moždanim udarom u anamnezi.
English: The pharmacokinetics of dextromethorphan/quinidine in paediatric patients has not been studied (see section 5.1).
Croatian: Pedijatrijska populacija Farmakokinetika dekstrometorfana / kinidina u pedijatrijskih bolesnika nije ispitana (vidjeti dio 5.1).
English: • The other ingredients are croscarmellose sodium, cellulose microcrystalline, silica colloidal, lactose monohydrate, magnesium stearate and gelatin, titanium dioxide (E171), red iron oxide (E172), printing ink (shellac glaze, propylene glycol, titanium dioxide (E171)).
Croatian: • Drugi sastojci su umrežena karmelozanatrij, mikrokristalična celuloza, koloidni silicijev dioksid, laktoza hidrat, magnezijev stearat i želatina, titanijev dioksid (E171), crveni željezov oksid (E172), tinta za označavanje (šelak glazura, propilenglikol, titanijev dioksid (E171)).
English: Pack size: 60 capsules
Croatian: Veličina pakiranja: 60 kapsula
English: The educational material for HCPs should assist them in the collection and assessment of relevant patient's details on pre-existing co-morbidities and concomitant medications prior to initiating Nuedexta therapy.
Croatian: Edukacijski materijal za zdravstvene djelatnike trebao bi im pomoći u pribavljanju i procjeni važnih bolesnikovih podataka o prethodnim komorbiditetima i lijekovima koje istovremeno uzima prije nego što započne terapiju lijekom Nuedexta.
English: If concomitant treatment with strong or moderate CYP3A4 inhibitors is considered necessary, it is recommended that electrocardiographic (ECG) evaluation of the QT interval be carried out before NUEDEXTA is administered and at appropriate time point(s) subsequently.
Croatian: Ako se istovremeno liječenje snažnim ili umjerenim inhibitorima CYP3A4 smatra potrebnim, preporučuje se da se prije primjene lijeka NUEDEXTA, a nakon toga u odgovarajućim vremenskim točkama, provodi procjena QT intervala elektrokardiogramom (EKG).
English: This medicine may cause dizziness and your doctor might need to discuss appropriate precautions to reduce the risk of falls.
Croatian: • ako ste skloni padovima; ovaj lijek može izazvati omaglicu i liječnik će možda trebati s Vama porazgovarati o odgovarajućim mjerama opreza, kako bi se umanjila opasnost od padova.
English: The frequency of PBA episodes as measured by “Count of Episodes” in both NUEDEXTA treatment groups decreased significantly throughout the course of the study by an incremental reduction of 47% and 49% relative to placebo, respectively (p <0.0001 for both comparisons).
Croatian: Učestalost epizoda pseudobulbarnog afekta mjerena kao „broj epizoda“ u obje skupine liječene NUEDEXTOM značajno se smanjila tijekom trajanja ispitivanja, postupnim smanjenjem od 47% odnosno 49% u odnosu na placebo (p<0,0001 za obje usporedbe).
English: These are medicines used to treat malaria or heart rhythm problems,
Croatian: To su lijekovi za liječenje malarije ili tegoba sa srčanim ritmom,
English: Quinidine is a potent inhibitor of CYP2D6.
Croatian: Kinidin je snažan inhibitor CYP2D6.
English: The first was a 4-week study in PBA subjects with underlying ALS, and the second was a 12-week study in subjects with underlying MS.
Croatian: Prvo ispitivanje trajalo je 4 tjedna i provedeno je u ispitanika s pseudobulbarnim afektom i ALS u podlozi, a drugo je trajalo 12 tjedana i provedeno je u ispitanika s MS u podlozi.
English: You should not drink grapefruit juice or eat grapefruits while you are taking NUEDEXTA as this can increase the likelihood of serious side effects.
Croatian: Dok uzimate lijek NUEDEXTA ne smijete piti sok od grejpa ili jesti grejp, jer to može povećati vjerojatnost pojave ozbiljnih popratnih učinaka.
English: In both studies the primary outcome measure, CNS-LS, and the secondary outcome measure, “count of episodes of laughing and crying”, were statistically significantly decreased by the dextromethorphan/quinidine combination.
Croatian: U oba ispitivanja mjera primarnog ishoda, CNS-LS te mjera sekundarnog ishoda „broj epizoda smijeha i plača“, bile su statistički značajno smanjene primjenom kombinacije dekstrometorfan / kinidin.
English: Quinidine at higher doses than in NUEDEXTA can cause immune-mediated thrombocytopenia that can be severe or fatal.
Croatian: Kinidin u dozama višim od onih koje sadrži NUEDEXTA može prouzročiti imunološki posredovanu trombocitopeniju, koja može biti teška ili smrtonosna.
English: • medicines used to prevent nausea and vomiting during chemotherapy and after surgery, such as aprepitant
Croatian: • lijekovi za sprječavanje mučnine i povraćanja tijekom kemoterapije i nakon kirurškog zahvata,
English: Given the pharmacodynamic and pharmacokinetic interactions, concomitant use of NUEDEXTA and TCAs is not recommended due to the elevated risk of serotonin syndrome (see section 4.5).
Croatian: S obzirom na farmakodinamičke i farmakokinetičke interakcije, ne preporučuje se istovremena primjena lijeka NUEDEXTA i tricikličkih antidepresiva, zbog povećanog rizika od serotoninskog sindroma (vidjeti dio 4.5).
English: Mean changes in QTcF were 6.8 ms for NUEDEXTA 23 mg/ 9 mg and 9.1 ms for the reference positive control (moxifloxacin).
Croatian: Srednje vrijednosti promjena u QTcF iznosile su 6,8 ms za skupinu NUEDEXTA 23 mg/ 9 mg i 9,1 ms za referentnu pozitivnu kontrolnu skupinu (moksifloksacin).
English: It is not known whether the active substances of NUEDEXTA are expressed into human milk.
Croatian: Nije poznato prelaze li djelatne tvari lijeka NUEDEXTA u majčino mlijeko.
English: • if you have a history of low levels of blood cells caused by quinidine, quinine or mefloquine (this can cause a tendency to bleed or bruise more easily than normal)
Croatian: • ako ste u prošlosti imali niski broj krvnih stanica prouzročenih kinidinom, kininom ili meflokinom (to može izazvati sklonost krvarenju ili stvaranju modrica češće nego što je normalno).
English: Digoxin and other P-glycoprotein substrates
Croatian: Digoksin i drugi supstrati P-glikoproteina
English: Titanium dioxide (E171) Red iron oxide (E172)
Croatian: Ovojnica kapsule želatina titanijev dioksid (E171) željezov oksid, crveni (172)
English: They include, but are not limited to, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil.
Croatian: Oni uključuju, ali nisu ograničeni samo na njih, atazanavir, klaritromicin, indinavir, itrakonazol, ketokonazol, nefazodon, nelfinavir, ritonavir, sakvinavir, telitromicin, amprenavir, aprepitant, diltiazem, eritromicin, flukonazol, fosamprenavir, sok od grejpa i verapamil.
English: Rare (may affect up to 1 in 1,000 people)
Croatian: Rijetke (mogu se javiti u do 1 od 1000 osoba)
English: NUEDEXTA is indicated for the symptomatic treatment of pseudobulbar affect (PBA) in adults (see section 4.4).
Croatian: NUEDEXTA indicirana je za simptomatsko liječenje pseudobulbarnog afekta u odraslih (vidjeti dio 4.4).
English: Do not take NUEDEXTA
Croatian: Nemojte uzimati NUEDEXTU
English: When concomitant use of a CYP2D6 substrate drug is considered necessary, the dose of the CYP2D6 substrate should be reduced as appropriate according to the pharmacokinetics of the substrate involved (see section 4.5).
Croatian: Kada se smatra da je neophodna istovremena upotreba lijeka koji je supstrat CYP2D6, dozu supstrata CYP2D6 treba smanjiti kako je odgovarajuće prema farmakokinetici uključenog supstrata (vidjeti dio 4.5).
English: NUEDEXTA must not be used with monoamine oxidase inhibitors (MAOIs), such as phenelzine and moklobemide, or in patients who have taken MAOIs within the preceding 14 days due to the risk of serotonin syndrome (see section 4.3).
Croatian: NUEDEXTA se ne smije uzimati s inhibitorima monoaminoksidaze (MAOI), kao što su fenelzin i moklobemid ili ga ne smiju uzimati bolesnici koji su uzimali MAOI unutar prethodnih 14 dana, zbog rizika od pojave serotoninskog sindroma (vidjeti dio 4.3).
English: The quinidine component is not expected to contribute to the effectiveness of NUEDEXTA in PMs, but adverse reactions of the quinidine component are still possible.
Croatian: Ne očekuje se da će komponenta kinidina pridonijeti učinkovitosti NUEDEXTE u slabih metabolizatora, ali su nuspojave komponente kinidina ipak moguće.
English: Each hard capsule contains 119.1 mg of lactose (as monohydrate).
Croatian: Jedna tvrda kapsula sadrži 119,1 mg laktoze (u obliku hidrata).
English: Treatment with an MAOI should not be initiated until at least 14 days after stopping NUEDEXTA (see section 4.5).
Croatian: Liječenje nekim inhibitorom monoaminoksidaze ne smije se započeti dok ne prođe najmanje 14 dana nakon obustave lijeka NUEDEXTA (vidjeti dio 4.5).
English: In the case of pro-drugs whose actions are mediated by the CYP2D6-produced metabolites (for example, codeine and hydrocodone, whose analgesic and antitussive effects appear to be mediated by morphine and hydromorphone, respectively), efficacy may be substantially reduced by NUEDEXTA due to inhibition of CYP2D6 and hence impaired formation of the active metabolite.
Croatian: U slučaju predlijekova, kojima je djelovanje posredovano metabolitima koje stvara CYP2D6 (primjerice kodein i hidrokodon, čije se analgetički i antitusivni učinci čine posredovani morfinom i hidromorfonom), djelotvornost može biti bitno smanjena lijekom NUEDEXTA, zbog inhibicije CYP2D6, čime se ometa stvaranje aktivnog metabolita.
English: Tricyclic antidepressants (TCAs e.g. desipramine, nortriptyline, imipramine, amitriptyline) are metabolised by CYP2D6 and therefore are also subject to pharmacokinetic interaction with quinidine.
Croatian: Triciklički antidepresivi (TCA, npr. desipramin, nortriptilin, imipramin, amitriptilin) metaboliziraju se putem CYP2D6, pa su stoga također podložni farmakokinetičkoj interakciji s kinidinom.
English: This includes patients with a family history of QT abnormality, concomitant medicinal products that prolong the QT interval, and patients with left ventricular hypertrophy (LVH) and/or left ventricular dysfunction (LVD).
Croatian: To uključuje bolesnike s obiteljskom anamnezom nepravilnog QT intervala, istodobnim uzimanjem lijekova koji produljuju QT interval i bolesnike s hipertrofijom lijeve klijetke (LVH) i/ili disfunkcijom lijeve klijetke (LVD).
English: No more than 2 capsules should be taken in any 24-hour period, with 12 hours between each dose.
Croatian: U razdoblju od 24 sata, ne smije se uzeti više od 2 kapsule, s razmakom od 12 sati između svake doze.
English: • weakness (asthenia), irritability
Croatian: • slabost (astenija), razdražljivost
English: Plasma concentrations of dextromethorphan and dextrorphan are proportional to dextromethorphan dose in the presence of a fixed dose of quinidine such as that contained in NUEDEXTA.
Croatian: Plazmatske koncentracije dekstrometorfana i dekstrorfana proporcionalne su dozi dekstrometorfana u prisustvu fiksne doze kinidina, kao što je ona koju sadrži NUEDEXTA.
English: CYP2D6 substrates include certain beta-blockers such as metoprolol, antipsychotics such as haloperidol, perphenazine and aripiprazole, antidepressants such as nortriptyline, imipramine, amitriptyline and desipramine, the chemotherapeutic tamoxifen, and the noradrenaline transporter inhibitor atomoxetine.
Croatian: Supstrati CYP2D6 uključuju određene beta blokatore kao što je metoprolol, antipsihotike kao što su haloperidol, perfenazin i aripiprazol, antidepresive kao što su nortriptilin, imipramin, amitriptilin i desipramin, kemoterapijske lijekove tamoksifen i atomoksetin, inhibitor prijenosnika noradrenalina.
English: Your doctor will start your treatment with NUEDEXTA 15 mg/9 mg capsules which should be taken by you as follows:
Croatian: Liječnik će započeti terapiju lijekom NUEDEXTA kapsulama 15 mg/9 mg, a morate ih uzimati ovako:
English: perphenazine, aripiprazole and chlorpromazine
Croatian: perfenazin, aripiprazol i klorpromazin
English: Dextromethorphan has been shown to be a mild/moderate inhibitor of the OCT1 transporter in vitro.
Croatian: Pokazalo se da je dekstrometorfan blagi/umjereni inhibitor prijenosnika OCT1 in vitro.
English: • you experience symptoms such as palpitations or fainting, which may be a sign of heart problems.
Croatian: • ako osjetite simptome kao što su lupanje srca (palpitacije) ili nesvjesticu, što može biti znak tegoba sa srcem.
English: Liver enzyme inducers
Croatian: Induktori jetrenih enzima
English: Combination with MAOIs is contraindicated (see section 4.3).
Croatian: Kontraindicirana je kombinacija s MAOI (vidjeti dio 4.3).
English: The card should contain details to alert any HCP treating the patient that they are being treated with Nuedexta and of the potential for interaction once a patient is on treatment with Nuedexta and another treatment is added.
Croatian: Ta kartica treba sadržavati pojedinosti kako bi svaki zdravstveni djelatnik koji liječi bolesnika bio upozoren na terapiju lijekom Nuedexta te na mogućnost interakcije kada se tekućoj terapiji lijekom Nuedexta doda dodatna terapija.
English: Shellac glaze (20% esterified) Propylene glycol Titanium dioxide (E171)
Croatian: Tinta za označavanje šelak glazura (20% esterificirana) propilenglikol titanijev dioksid (E171)
English: • medicines used to treat HIV infection and AIDS, such as atazanavir, indinavir, nelfinavir,
Croatian: • lijekovi za liječenje infekcije HIV-om te AIDS-a, kao što su atazanavir, indinavir, nelfinavir,
English: Approximately 1-10% of individuals of Caucasian descent, 5-30% of Black African descent, 12-40% of Arab descent and 1% of Asian descent exhibit increased metabolic activity for CYP2D6 substrates and are classified as Ultra-rapid Metabolizer (UMs).
Croatian: Približno 1-10% bijelaca, 5-30% crnaca, 12-40% osoba arapskog podrijetla i 1% azijata pokazalo je povećanu metaboličku aktivnost prema supstratima CYP2D6 i klasificirani su kao ultrabrzi metabolizatori.
English: 13 hard capsules
Croatian: 13 tvrdih kapsula
English: Neither dextromethorphan nor quinidine induced CYP1A2, CYP2B6 or CYP3A4 in human hepatocytes at concentrations up to 4.8 µM.
Croatian: Ni dekstrometorfan ni kinidin nisu inducirali CYP1A2, CYP2B6 ili CYP3A4 u ljudskim hepatocitima pri koncentracijama do 4,8 µM.
English: Concomitant administration of medicines that inhibit CYP3A4 can be expected to increase plasma levels of quinidine, which could increase risk relating to QTc prolongation.
Croatian: Može se očekivati da će istovremena primjena lijekova koji inhibiraju CYP3A4 povećati razine kinidina u plazmi, što bi moglo povećati rizik koji se odnosi na produljenje QTc intervala.
English: The mean plasma Cmax of quinidine following NUEDEXTA 15 mg / 9 mg twice daily in subjects with PBA was 1 to 3% of the therapeutic concentrations associated with antiarrhythmic efficacy (2 to 5 µg/mL).
Croatian: Srednja vrijednost Cmax kinidina u plazmi nakon lijeka NUEDEXTA 15 mg/9 mg dvaput na dan u ispitanika s pseudobulbarnim afektom, iznosila je 1 do 3% terapijskih koncentracija povezanih s djelotvornošću antiaritmika (2 do 5 µg/mL).
English: This test dose is adequate to represent the steady state exposure in patients with CYP2D6 extensive metabolizer phenotype.
Croatian: Ova testna doza odgovarajuće predstavlja izloženost u stanju dinamičke ravnoteže u bolesnika s fenotipom ekstenzivnih metabolizatora CYP2D6.
English: After administration of NUEDEXTA 23 mg/9 mg to 14 extensive metabolizers, the elimination halflife of dextromethorphan was 18.8 hours and the elimination half-life of quinidine was 9.6 hours.
Croatian: Nakon primjene lijeka NUEDEXTA 23 mg/9 mg u 14 ekstenzivnih metabolizatora, poluživot eliminacije dekstrometorfana bio je 18,8 sati a poluživot eliminacije kinidina 9,6 sati.
English: Renal clearance involves both glomerular filtration and active tubular secretion, moderated by (pH-dependent) tubular reabsorption.
Croatian: Klirens putem bubrega uključuje i glomerularnu filtraciju i aktivnu tubularnu sekreciju, ograničenu tubularnom reapsorpcijom (ovisnoj o pH).
English: Dose adjustment is not required in patients with a non-functional CYPD2D6 enzyme, referred to as poor metabolisers (PMs).
Croatian: Prilagodba doze nije potrebna u bolesnika s nefunkcionalnim enzimom CYPD2D6, koji se nazivaju slabi metabolizatori.
English: The no effect dose in rabbits is 2 and 60 times higher than the RHD.
Croatian: Doza bez učinka u kunića viša je 2 do 60 puta od doze preporučene u ljudi.
English: Erythema, Hyperhidrosis, Hypoaesthesia facial, Night sweats
Croatian: Rijetko eritem, hiperhidroza, facijalna hipoestezija, noćna znojenja