FrancophonIA/ELRC3.0 huggingface dataset:
English: High blood pressure increases the workload of the heart and arteries.
Croatian: Povišeni krvni tlak povećava radno opterećenje srca i arterija.
English: Rasilez HCT with food and drink
Croatian: Rasilez HCT s hranom i pićem
English: Aliskiren is a renin inhibitor.
Croatian: Aliskiren je inhibitor renina.
English: It should not be used in children from 2 to less than 6 years of age, and is not recommended for use in children and adolescents from 6 to less than 18 years of age.
Croatian: Ne bi se smio primjenjivati u djece u dobi od 2 do 6 godina i ne preporučuje se za primjenu u djece i adolescenata u dobi od 6 do 18 godina.
English: However, CYP3A4 inhibitors often also affect Pgp.
Croatian: Međutim, CYP3A4 inhibitori također često utječu na P-gp.
English: During your treatment, your doctor may adjust your dose depending on your blood pressure response.
Croatian: Tijekom liječenja, liječnik može prilagoditi dozu zavisno od odgovora krvnog tlaka.
English: The absolute bioavailability of aliskiren is approximately 2-3%.
Croatian: Apsolutna bioraspoloživost aliskirena je približno 2-3%.
English: If this is the case, your doctor will tell you how to switch from that treatment to Rasilez HCT.
Croatian: U tom slučaju će Vam liječnik objasniti kako se prebaciti s tog liječenja na Rasilez HCT.
English: - if you suffer from a disease called lupus erythematosus (also called “lupus” or “SLE”).
Croatian: - ako bolujete od bolesti zvane sistemski eritematozni lupus (također zvana „lupus“ ili „SLE“).
English: The average differences between aliskiren and placebo for the low and mid dose groups were <0.2 mmHg.
Croatian: Prosječne razlike između aliskirena i placeba za grupe s niskom i srednjom dozom iznosile su <0,2 mmHg.
English: Your doctor will normally advise you to stop taking this medicine before you become pregnant and will advise you to take another medicine instead of this medicine.
Croatian: Liječnik će Vas u pravilu savjetovati da prekinete uzimati ovaj lijek prije nego postanete trudni te će Vam savjetovati da uzmete drugi lijek umjesto ovog lijeka.
English: There was no evidence that this finding was enhanced in the aliskiren/hydrochlorothiazide combination as it was only apparent at a minimal severity in all animals.
Croatian: Nije bilo dokaza da je ovaj nalaz pojačan u kombinaciji aliskiren/hidroklorotiazid, jer je on bio samo minimalno izražen u svih životinja.
English: There were no new or unexpected findings observed of relevance to human use.
Croatian: Nisu opaženi novi ili neočekivani nalazi značajni za primjenu u ljudi.
English: Thiazides in high doses causing intense diuresis can inhibit milk production.
Croatian: Tiazidi u visokim dozama koje izazivaju intenzivnu diurezu mogu inhibirati proizvodnju mlijeka.
English: You must tell your doctor if you think you are (or might become) pregnant.
Croatian: Morate obavijestiti svog liječnika ako mislite da ste (ili možete postati) trudni.
English: Swallow the tablet whole with some water.
Croatian: Progutajte cijelu tabletu s nešto vode.
English: The systemic exposure to aliskiren in 8-day old rats was >400-fold higher than in adult rats.
Croatian: Sistemska izloženost aliskirenu u štakora starih 8 dana bila je >400 puta viša nego u odraslih štakora.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: • prilikom svake izmjene sustava za upravljenje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: • Red skin (erythema)
Croatian: • crvena koža (eritem)
English: Both of these active substances help to control high blood pressure (hypertension).
Croatian: Obje djelatne tvari pomažu u kontroli povišenog krvnog tlaka (hipertenzije).
English: There is no change in the kinetics of hydrochlorothiazide on repeated dosing, and accumulation is minimal when dosed once daily.
Croatian: Nema promjene u kinetici hidroklorotiazida pri ponovljenom doziranju, a nakupljanje je minimalno kad se dozira jednom dnevno.
English: Hydrochlorothiazide is eliminated from plasma with a half-life averaging 6 to 15 hours in the terminal elimination phase.
Croatian: Hidroklorotiazid se eliminira iz plazme s prosječnim poluvijekom od 6 do 15 sati u terminalnoj fazi eliminacije.
English: If any of the following occur, tell your doctor straight away:
Croatian: Ako se dogodi nešto od sljedećih nuspojava, odmah obavijestite svojeg liječnika:
English: The results of this study did not suggest that age, body weight or gender have any significant effect on aliskiren systemic exposure (see section 4.2).
Croatian: Rezultati ovog ispitivanja nisu upućivali na to da dob, tjelesna težina ili spol imaju bilo kakav značajan učinak na sistemsku izloženost aliskirenu (vidjeti dio 4.2).
English: Risk of symptomatic hypotension
Croatian: Rizik od simptomatske hipotenzije
English: • Decrease in vision or pain in your eyes due to high pressure (possible signs of acute-angle closure glaucoma)
Croatian: • smanjenje vida ili bol u Vašim očima uslijed visokog tlaka (mogući znaci akutnoga glaukoma zatvorenog kuta)
English: Hydrochlorothiazide has been extensively prescribed for many years, frequently in higher doses than those contained in Rasilez HCT.
Croatian: Hidroklorotiazid je u širokoj primjeni već mnogo godina i često u dozama višim od onih sadržanih u Rasilez HCT-u.
English: Fertility There are no clinical data on fertility.
Croatian: Plodnost Nema kliničkih podataka o plodnosti.
English: Therefore, aliskiren is not expected to affect the systemic exposure of substances that inhibit, induce or are metabolised by these enzymes.
Croatian: Zbog toga se ne očekuje da aliskiren utječe na sistemsku izloženost lijekovima koji te enzime inhibiraju, induciraju ili se metaboliziraju tim enzimima.
English: The enzyme responsible for this metabolism is CYP3A4.
Croatian: Enzim odgovoran za taj metabolizam je CYP3A4.
English: Depressionh, sleep disturbancesh
Croatian: Depresijah, poremećaji spavanjah
English: The study was discontinued prematurely because the participants were unlikely to benefit from aliskiren.
Croatian: Ispitivanje je bilo prijevremeno prekinuto jer nije bilo vjerojatno da će ispitanici imati koristi od aliskirena.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 16 January 2009
Croatian: Datum prvog odobrenja: 16. siječnja 2009.
English: Different treatment effects of aliskiren were reported for overall mortality within 12 months dependent on diabetes mellitus status.
Croatian: Različiti terapijski učinci aliskirena zabilježeni su za ukupnu smrtnost u roku od 12 mjeseci ovisno o statusu šećerne bolesti.
English: • Low level of blood platelets (sometimes with bleeding or bruising underneath the skin)
Croatian: • niska razina krvnih pločica (ponekad s krvarenjem ili stvaranjem modrica ispod kože)
English: P-gp interactions
Croatian: P-gp interakcije
English: However the efficacy of aliskiren was similar when taken with a light meal or under fasted state.
Croatian: Međutim, djelotvornost aliskirena bila je slična kad se uzimao s laganim obrokom ili natašte.
English: It is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Croatian: Ne preporučuje za vrijeme trudnoće te se ne smije uzimati ako ste trudni više od 3 mjeseca, jer može ozbiljno naštetiti Vašem djetetu ako se koristi nakon trećeg mjeseca trudnoće.
English: The starting dose in each group was assigned depending on weight with three groups: ≥20 to <50 kg, ≥50 to <80 kg, and ≥80 to ≤150 kg.
Croatian: Početna doza u svakoj skupini dodijeljena je ovisno o težini uz postojanje tri skupine: ≥20 do <50 kg, ≥50 do <80 kg i ≥80 do ≤150 kg.
English: Overall, the mean age of the patients was 11.8 years with 48.6% of patients being in the 6-11 years age group and 51.4% in the 12-17 years age group.
Croatian: Sveukupno, srednja dob bolesnika bila je 11,8 godina, pri čemu je 48,6 % bolesnika bilo u skupini od 6 do 11 godina, a 51,4 % bolesnika u skupini od 12 do 17 godina.
English: Hence, interactions due to inhibition or induction of CYP450 isoenzymes are not expected.
Croatian: Zbog toga se ne očekuju interakcije zbog inhibicije ili indukcije CYP450 izoenzima.
English: 85 to 90% of the maximal bloodpressure-lowering effect was observed after 2 weeks.
Croatian: Nakon 2 tjedna opaženo je 85 do 90% maksimalnog učinka sniženja krvnoga tlaka.
English: Circulating hydrochlorothiazide is bound to serum proteins (40-70%), mainly serum albumin.
Croatian: Cirkulirajući hidroklorotiazid se veže na serumske proteine (40-70%), uglavnom na serumski albumin.
English: A high inter-individual variability of mRNA expression levels was observed (up to 600-fold).
Croatian: Uočena je velika varijabilnost između pojedinaca u razinama ekspresije mRNK (do 600 puta).
English: The treatment with aliskiren was well tolerated in this study.
Croatian: Liječenje aliskirenom dobro je podnošeno u ovom ispitivanju.
English: If you only remember the forgotten dose the next day, you should simply take the next tablet at the usual time.
Croatian: Ako se sjetite zaboravljene doze tek idući dan, onda jednostavno u uobičajeno vrijeme uzmite sljedeću dozu.
English: The age at which the transporter system is mature cannot be determined (see sections 5.2 and 5.3).
Croatian: Dob u kojoj je sustav prijenosa zreo ne može se utvrditi (vidjeti dijelove 5.2 i 5.3).
English: The frequency, type and severity of adverse reactions in children were generally similar to those seen in hypertensive adults.
Croatian: Učestalost, vrsta i težina nuspojava u djece bile su općenito slične onima viđenim u hipertenzivnih odraslih osoba.
English: The absorption of hydrochlorothiazide, after an oral dose, is rapid (Tmax about 2 h).
Croatian: Apsorpcija hidroklorotiazida nakon peroralne doze je brza (tmax oko 2h).
English: Hydrochlorothiazide should not be used for essential hypertension in pregnant women except in rare situations where no other treatment could be used.
Croatian: Hidroklorotiazid se ne smije primjenjivati u liječenju esencijalne hipertenzije u trudnica, osim u rijetkim situacijama kada se ne može primijeniti nijedno drugo liječenje.
English: These could be symptoms of an increase of pressure in your eye and can happen within hours to weeks of taking this medicine.
Croatian: Ti simptomi mogli bi biti simptomi povišenog tlaka u Vašem oku, koji se može pojaviti unutar nekoliko sati do nekoliko tjedana nakon uzimanja ovog lijeka.
English: - if you have diabetes (high level of sugar in your blood).
Croatian: - ako imate šećernu bolest (povišena razina šećera u krvi).
English: The frequency of adverse reactions listed below is defined using the following convention: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000) and not known (cannot be estimated from the available data).
Croatian: Učestalost niže navedenih nuspojava je definirana na sljedeći način: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Hydrochlorothiazide is eliminated predominantly as unchanged compound.
Croatian: Hidroklorotiazid se eliminira uglavnom kao nepromijenjen lijek.
English: The clinical implications of the effects on PRA are not known at the present time.
Croatian: Trenutno nisu poznate kliničke implikacije učinka na APR.
English: Thrombocytopenia sometimes with purpurah
Croatian: Trombocitopenija, ponekad s purpuromh
English: • Worsening of the diabetic metabolic state
Croatian: • pogoršanje dijabetičkog metaboličkog stanja
English: See section 4.2, 4.8, 5.1 and 5.2 for information on paediatric use.
Croatian: Vidjeti dijelove 4.2, 4.8, 5.1 i 5.2 za informacije o pedijatrijskoj primjeni.
English: The primary endpoint was cardiovascular death or heart failure rehospitalisation within 6 months; secondary endpoints were assessed within 12 months.
Croatian: Primarni ishod bio je kardiovaskularna smrt ili ponovna hospitalizacija zbog zatajenja srca u roku od 6 mjeseci; sekundarni ishodi bili su procijenjeni u roku od 12 mjeseci.
English: Juvenile animal studies
Croatian: Ispitivanja na mladim životinjama
English: Palpitationsa, oedema peripherala
Croatian: Palpitacijea, periferni edema
English: Aliskiren was not teratogenic in rats or rabbits (see section 5.3).
Croatian: Aliskiren nije bio teratogen u štakora ili kunića (vidjeti dio 5.3).
English: Therefore, because of the risk of therapeutic failure, fruit juice should not be taken together with Rasilez HCT.
Croatian: Stoga se zbog rizika od terapijskog neuspjeha voćni sok ne bi smio uzimati zajedno s Rasilez HCT-om.
English: Symptomatic hypotension could occur after initiation of treatment with Rasilez HCT in the following cases:
Croatian: Simptomatska hipotenzija se može pojaviti nakon početka liječenja Rasilez HCT-om u sljedećim slučajevima:
English: Fruit juice and drinks containing plant extracts
Croatian: Voćni sok i napitci koji sadrže biljne ekstrakte
English: The combination of these substances with complementary mechanisms of action provides an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone.
Croatian: Kombincija ovih lijekova s komplementarnim mehanizmima djelovanja osigurava aditivni antihipertenzivni učinak snizujući krvni tlak u većoj mjeri nego svaki sastojak zasebno.
English: There is more than 95% of the absorbed dose being excreted as unchanged compound in the urine.
Croatian: Više od 95% apsorbirane doze se izlučuje u nepromijenjenom obliku u mokraći.
English: The safety of Rasilez HCT has been evaluated in more than 3,900 patients, including over 700 treated for over 6 months, and 190 for over 1 year.
Croatian: Sigurnost Rasilez HCT-a ispitivana je u više od 3900 bolesnika, uključujući više od 700 bolesnika liječenih dulje od 6 mjeseci te više od 190 bolesnika liječenih dulje od 1 godine.
English: The available clinical data do not suggest an additive effect of different types of foods and/or drinks, however the potential for decreased aliskiren bioavailability due to this additive effect has not been studied and therefore cannot be excluded.
Croatian: Dostupni klinički podaci ne upućuju na dodatni učinak različite vrste hrane i/ili pića, međutim potencijal smanjenja bioraspoloživosti aliskirena zbog takvog dodatnog učinka nije bio ispitivan te se stoga ne može isključiti.
English: Warnings and precautions Talk to your doctor before taking Rasilez HCT: - if you have had skin cancer or if you develop an unexpected skin lesion during the treatment.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku prije nego uzmete Rasilez HCT: - ako ste imali rak kože ili ako Vam se pojavi neočekivana lezija (promjena) na koži tijekom liječenja.
English: Aliskiren does not induce CYP3A4.
Croatian: Aliskiren ne inducira CYP3A4.
English: This medicine is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed.
Croatian: Ovaj lijek se ne preporučuje majkama koje doje, a ako želite dojiti liječnik Vam može odabrati drugo liječenje.
English: What Rasilez HCT is and what it is used for What you need to know before you take Rasilez HCT How to take Rasilez HCT
Croatian: Što je Rasilez HCT i za što se koristi Što morate znati prije nego počnete uzimati Rasilez HCT Kako uzimati Rasilez HCT
English: - if you have a high level of cholesterol or triglycerides in your blood.
Croatian: - ako imate povišene razine kolesterola ili triglicerida u krvi.
English: Respiratory distress (including pneumonitis and pulmonary oedema) h
Croatian: Respiratorni distres (uključujući pneumonitis i plućni edem) h
English: Although meals (low or high fat content) have been shown to reduce the absorption of aliskiren substantially, the efficacy of aliskiren was shown to be similar when taken either with a light meal or without a meal (see section 4.2).
Croatian: Iako se pokazalo da obroci (s niskim ili visokim sadržajem masti) značajno smanjuju apsorpciju aliskirena, djelotvornost aliskirena se pokazala sličnom kad se uzima s laganim obrokom ili bez obroka (vidjeti dio 4.2).
English: Limited data suggest that the systemic clearance of hydrochlorothiazide is reduced in both healthy and hypertensive elderly subjects compared to young healthy volunteers.
Croatian: Ograničeni podaci upućuju na to da je sistemski klirens hidroklorotiazida smanjen u zdravih i u hipertenzivnih starijih ispitanika u usporedbi s mladim zdravim dobrovoljcima.
English: No specific clinical studies have been performed with this combination, therefore Rasilez HCT should not be used during the first trimester of pregnancy or in women planning to become pregnant and is contraindicated during the second and third trimesters (see section 4.3).
Croatian: Nisu provedena posebna klinička ispitivanja s ovom kombinacijom, stoga se Rasilez HCT ne smije primjenjivati tijekom prvog tromjesečja trudnoće, ili u žena koje planiraju zatrudnjeti te je kontraindiciran tijekom drugog i trećeg tromjesečja (vidjeti dio 4.3).
English: Approximately 1.4% of the total oral dose is metabolised.
Croatian: Metabolizira se približno 1,4% ukupne peroralne doze.
English: Contraindicated (see section 4.3)
Croatian: Kontraindicirano (vidjeti dio 4.3)
English: Hypotensionc,a
Croatian: Hipotenzijac,a
English: If any of the above applies to you, do not take Rasilez HCT and talk to your doctor.
Croatian: Ako se bilo što od navedenog odnosi na Vas, nemojte uzimati Rasilez HCT i obavijestite svog liječnika.
English: If this happens, stop taking this medicine and contact your doctor.
Croatian: Ako se to dogodi, prestanite uzimati ovaj lijek i javite se svojem liječniku.
English: One colonic adenoma and one caecal adenocarcinoma recorded in rats at the dose of 1500 mg/kg/day were not statistically significant.
Croatian: Jedan adenom kolona i jedan adenokarcinom cekuma, koji su zabilježeni u štakora pri dozi od 1500 mg/kg/dan, nisu bili statistički značajni.
English: In most patients arterial blood pressure was well controlled at baseline.
Croatian: U većine bolesnika arterijski krvni tlak bio je dobro kontroliran na početku.
English: Aliskiren does not inhibit the CYP450 isoenzymes (CYP1A2, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A).
Croatian: Aliskiren ne inhibira CYP450 izoenzime (CYP1A2, 2C8, 2C9, 2C19, 2D6, 2E1 i 3A).
English: Other substances that act directly on the RAAS have been associated with serious foetal malformations and neonatal death when used during second and third trimesters.
Croatian: Drugi lijekovi koje djeluju direktno na RAAS povezani su s ozbiljnim malformacijama fetusa i neonatalnom smrću kada su se primjenjivale tijekom drugog i trećeg tromjesečja.
English: Mean weight was 68.0 kg with 57.7% of patients having BMI greater than or equal to the 95th percentile for age and gender.
Croatian: Srednja vrijednost težine iznosila je 68,0 kg, pri čemu je 57,7 % bolesnika imalo BMI viši od ili jednak 95. percentili za dob i spol.
English: Meals with a high fat content reduce Cmax by 85% and AUC by 70%.
Croatian: Obroci s visokim sadržajem masti smanjuju Cmax za 85% i AUC za 70%.
English: Hydrochlorothiazide also accumulates in erythrocytes at approximately 3 times the level in plasma.
Croatian: Hidroklorotiazid se također nakuplja u eritrocitima s razinom približno 3 puta većom od razine u plazmi.
English: Hypotension and related adverse events were uncommon with the combination treatment, with no increased incidence in elderly patients.
Croatian: Hipotenzija i povezani štetni događaji su bili manje česti u kombiniranom liječenju, bez povećane incidencije u starijih bolesnika.
English: Patients should establish a convenient daily schedule of medicinal product intake and maintain a steady temporal relationship with food intake.
Croatian: Bolesnici trebaju uspostaviti pogodan dnevni raspored uzimanja lijeka i održavati postojanu vremensku povezanost s unosom hrane.
English: See also section “Do not take Rasilez HCT”.
Croatian: Vidjeti također dio „Nemojte uzimati Rasilez HCT“
English: Aliskiren is mainly eliminated as unchanged compound in the faeces (oral radioactive dose recovery = 91%).
Croatian: Aliskiren se uglavnom eliminira kao nepromijenjeni lijek u stolici (izlučivanje peroralne radioaktivne doze = 91%).
English: Keep your appointments with the doctor even if you are feeling well.
Croatian: Ne propuštajte kontrole kod svojeg liječnika čak i ako se osjećate dobro.
English: This medicine is used to treat high blood pressure in adult patients.
Croatian: Ovaj lijek se koristi za liječenje povišenog krvnog tlaka u odraslih bolesnika.
English: ** Including one case of “liver failure fulminant” reported in the post-marketing experience, for which a causal relationship with aliskiren cannot be excluded.
Croatian: **Uključujući jedan slučaj ‘fulminantnog zatajenja jetre' prijavljen nakon stavljanja lijeka u promet, za kojeg se uzročno-posljedična veza s aliskirenom ne može isključiti.
English: − Hereditary or idiopathic angioedema.
Croatian: Nasljedni ili idiopatski angioedem.
English: Therefore, the potential exists for interactions between OATP inhibitors and aliskiren when administered concomitantly (see section “Fruit juice and drinks containing plant extracts” above).
Croatian: Stoga postoji potencijal za interakcije između inhibitora OATP-a i aliskirena kada se primjenjuju istodobno (vidjeti dio „Voćni sok i napitci koji sadrže biljne ekstrakte“ iznad).
English: Rasilez HCT contains lactose and wheat starch (containing gluten) This medicine contains lactose (milk sugar).
Croatian: Rasilez HCT sadrži laktozu i pšenični škrob (koji sadrži gluten) Ovaj lijek sadrži laktozu (mliječni šećer).
English: Hepatic MDR1 mRNA expression was statistically significantly lower in samples from foetuses, neonates and infants up to 23 months.
Croatian: Ekspresija mRNK za MDR1 u jetri bila je statistički značajno niža u uzorcima od fetusa, novorođenčadi i dojenčadi do 23 mjeseca.
English: Rasilez HCT is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see section “Pregnancy”).
Croatian: Rasilez HCT se ne preporučuje u ranoj trudnoći i ne smije se uzimati ako ste trudni više od 3 mjeseca, jer može ozbiljno naštetiti Vašem djetetu ako se koristi u toj fazi (vidjeti dio „Trudnoća“).
English: Reproductive toxicity studies with aliskiren did not reveal any evidence of embryofoetal toxicity or teratogenicity at doses up to 600 mg/kg/day in rats or 100 mg/kg/day in rabbits.
Croatian: Ispitivanja reproduktivne toksičnosti s aliskirenom nisu otkrila dokaz embriofetalne toksičnosti ili teratogenosti pri dozama do 600 mg/kg/dan u štakora, ili 100 mg/kg/dan u kunića.
English: This medicine may make you feel dizzy.
Croatian: Od ovog lijeka možete osjetiti omaglicu.
English: The safety of the combination therapy was similar to the respective monotherapies regardless of severity of hypertension or of the presence or absence of additional cardiovascular risk.
Croatian: Sigurnost kombinirane terapije bila je slična onoj za odgovarajuće monoterapije bez obzira na težinu hipertenzije te prisutnost ili odsutnost dodatnog kardiovaskularnog rizika.
English: If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA.
Croatian: Ako se ponovna primjena diuretika smatra neophodnom, preporučuje se zaštita izloženih područja od sunca ili umjetnog UVA zračenja.