FrancophonIA/ELRC3.0 huggingface dataset:
English: Concomitant administration of Lopinavir/Ritonavir Mylan with fusidic acid is contra-indicated in dermatological indications due to the increased risk of adverse events related to fusidic acid, notably rhabdomyolysis (see section 4.3).
Slovenian: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan s fusidno kislino je kontraindicirana pri dermatoloških indikacijah, ker obstaja večje tveganje za neželene učinke, povezane s fusidno kislino, zlasti za rabdomiolizo (glejte poglavje 4.3).
English: * weight based dosing recommendations are based on limited data If more convenient for patients, the lopinavir/ritonavir 200/50 mg tablets may also be considered alone or in combination with the lopinavir/ritonavir 100/25 mg tablet to achieve the recommended dose.
Slovenian: Če je za bolnika bolj priročno, se za doseganje priporočenega odmerka lahko razmisli o samostojnem dajanju 200 mg/50 mg tablet lopinavirja/ritonavirja ali v kombinaciji s 100 mg/25 mg tabletami lopinavirja/ritonavirja.
English: Clinical recommendation concerning co-administration with Lopinavir/Ritonavir Mylan
Slovenian: Klinično priporočilo glede sočasne uporabe z zdravilom Lopinavir/ritonavir Mylan
English: The maximum mean (95% upper confidence bound) differences in QTcF from placebo were 3.6 (6.3) and 13.1(15.8) for 400/100 mg twice daily and supratherapeutic 800/200 mg twice daily LPV/r, respectively.
Slovenian: Največja povprečna razlika (95% zgornja meja zaupanja) QTcF v primerjavi s placebom je bila 3,6 (6,3) med uporabo lopinavirja/ritonavirja 400 mg/100 mg dvakrat na dan in 13,1 (15,8) med uporabo supraterapevtskega odmerka lopinavirja/ritonavirja 800 mg/200 mg dvakrat na dan. K podaljšanju intervala QT pripomore podaljšanje intervala QRS s 6 ms na 9,5 ms, ki ga povzročijo veliki odmerki lopinavirja/ritonavirja (800 mg/200 mg dvakrat na dan).
English: − Do not take lopinavir/ritonavir if you are currently taking avanafil or vardenafil.
Slovenian: Zdravila za zdravljenje erek tilne disfunkcije (avanafil, vardenafil, sildenafil, tadalafil) - Ne jemljite lopinavirja/ritonavirja, če trenutno jemljete avanafil ali vardenafil.
English: Therefore, the antiviral activity of lopinavir/ritonavir is due to lopinavir.
Slovenian: Protivirusno delovanje lopinavirja/ritonavirja je torej posledica lopinavirja.
English: HIV RNA < 400 copies/ml Mean increase from baseline in CD4+ T-cell count (cells/mm3)
Slovenian: HIV RNA < 400 kopij/ml* HIV RNA < 50 kopij/ml*† Srednje povečanje števila T- celic CD4 od začetka (celic/mm3)
English: They were randomised in a 1:1 ratio to receive either lopinavir/ritonavir 800/200 mg once daily (n = 300) or lopinavir/ritonavir 400/100 mg twice daily (n = 299).
Slovenian: V razmerju 1:1 so jih randomizirali na zdravljenje z lopinavirjem/ritonavirjem 800 mg/200 mg enkrat na dan (n = 300) ali lopinavirjem/ritonavirjem 400 mg/100 mg dvakrat na dan (n = 299).
English: 3 tablets (300/75 mg) 4 tablets (400/100 mg)
Slovenian: 3 tablete (300 mg/75 mg) 4 tablete (400 mg/100 mg) *priporočila za odmerjanje na osnovi telesne mase so pripravljena na osnovi omejenih podatkov
English: All patients were non-nucleoside reverse transcriptase inhibitor naïve.
Slovenian: Vsi bolniki predhodno niso bili zdravljeni z nenukleozidnimi zaviralci reverzne transkriptaze.
English: This medicinal product contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free'.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan vsebuje natrij To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na tableto, kar v bistvu pomeni ''brez natrija''.
English: They are available in blister multipacks of 60 or 60x1 (2 cartons of 30 or 30x1) film-coated tablets and in plastic bottles (containing a desiccant, which should not be eaten) of 60 film-coated tablets.
Slovenian: Zdravilo je na voljo v skupnih pakiranjih s pretisnimi omoti s 60, 60 x 1 (2 škatli po 30 ali 30 x 1) filmsko obloženo tableto in v vsebnikih (s sušilnim sredstvom, ki se ga ne smete zaužiti) s 60 filmsko obloženimi tabletami.
English: Due to CYP3A and P-gp inhibition by lopinavir/ritonavir.
Slovenian: Zaradi inhibicije CYP3A in P-gp z lopinavirjem/ritonavirjem
English: Recommended lopinavir/ritonavir dosing (mg) twice daily.
Slovenian: Priporočeno odmerjanje lopinavirja/ritonavirja (mg) dvakrat na dan.
English: Sildenafil used to treat erectile dysfunction may be taken under doctor's supervision (see Other medicines and Lopinavir/ritonavir Mylan section);
Slovenian: Siledenafil se lahko za zdravljenje erektilne disfunkcije uporablja pod nadzorom zdravnika (glejte poglavje Druga zdravila in zdravilo Lopinavir/ritonavir Mylan); - zdravila, ki vsebujejo šentjanževko (Hypericum perforatum).
English: When co-administered with carbamazepine or phenobarbital, an increase of Lopinavir/Ritonavir Mylan dosage may be envisaged.
Slovenian: Med sočasno uporabo s karbamazepinom ali fenobarbitalom je treba predvideti povečanje odmerka zdravila Lopinavir/ritonavir Mylan.
English: Multipack: 360 (3 bottles of 120) film-coated tablets
Slovenian: Skupno pakiranje: 360 (3 vsebniki s 120) filmsko obloženimi tabletami.
English: How to take Lopinavir/Ritonavir Mylan
Slovenian: Kako jemati zdravilo Lopinavir/ritonavir Mylan
English: Mean baseline CD4+ T-cell count was 838 cells/mm3 and mean baseline plasma HIV-1 RNA was 4.7 log10 copies/ml.
Slovenian: Povprečno izhodiščno število celic CD4 je bilo 838 celic/mm3, povprečna izhodiščna HIV-1 RNA v plazmi pa 4,7 log10 izvodov/ml.
English: Tipranavir/ritonavir (500/100 mg BID)
Slovenian: tipranavir/ ritonavir (500 mg/100 mg dvakrat na dan)
English: Indinavir, 600 mg BID Indinavir: AUC: ↔
Slovenian: indinavir, 600 mg dvakrat na dan indinavir:
English: (Lopinavir/ritonavir 400/100 mg BID, multiple dose)
Slovenian: (Lopinavir/ritonavir 400 mg/100 mg dvakrat na dan, večkratni odmerek)
English: − Nausea, vomiting, abdominal pain, difficulty breathing and severe weakness of the muscles in the legs and arms as these symptoms may indicate raised lactic acid levels.
Slovenian: - Siljenje na bruhanje, bruhanje, bolečine v trebuhu, ker ti simptomi lahko nakazujejo na pankreatitis (vnetje trebušne slinavke).
English: INFORMATION IN BRAILLE Lopinavir/Ritonavir Mylan 100 mg/25 mg
Slovenian: Lopinavir/ritonavir Mylan 100 mg/25 mg
English: No dose adjustment is needed for Lopinavir/Ritonavir Mylan.
Slovenian: Potrebna je lahko prilagoditev odmerka zdravila Lopinavir/ritonavir Mylan.
English: Lopinavir/Ritonavir Mylan tablets contain lopinavir and ritonavir, both of which are inhibitors of the P450 isoform CYP3A in vitro.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan vsebuje lopinavir in ritonavir, ki in vitro oba zavirata izoobliko CYP3A P450.
English: Lopinavir/ritonavir tablets can be taken with or without food.
Slovenian: Tablete lopinavirja/ritonavirja se lahko jemljejo s hrano ali brez nje.
English: Analgesics Fentanyl
Slovenian: Analgetiki fentanil fentanil:
English: For the treatment of pulmonary arterial hypertension: Coadministration of Lopinavir/Ritonavir Mylan with sildenafil is contraindicated (see section 4.3).
Slovenian: Za zdravljenje pljučne arterijske hipertenzije: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan s sildenafilom je kontraindicirana (glejte poglavje 4.3).
English: A series of blood samples were collected pre-dose and at intervals over the course of 12 hours in trimester 2 and trimester 3, at birth, and 4-6 weeks postpartum (in women who continued treatment postdelivery) for pharmacokinetic analysis of total and unbound levels of plasma lopinavir concentrations.
Slovenian: Za farmakokinetične analize plazemske koncentracije celokupnega in nevezanega lopinavirja so zbirali serijo krvnih vzorcev pred odmerki in v intervalih po preteku 12 ur v drugem in tretjem trimesečju, ob porodu in 4 - 6 tednov po porodu (pri ženskah, ki so nadaljevanje z zdravljenjem po porodu).
English: Lopinavir/ritonavir pharmacokinetics have not been studied in patients with renal insufficiency; however, since the renal clearance of lopinavir is negligible, a decrease in total body clearance is not expected in patients with renal insufficiency.
Slovenian: A ker je ledvični očistek lopinavirja zanemarljiv, pri bolnikih z ledvično insuficienco ni pričakovati zmanjšanja celotnega telesnega očistka.
English: It is important that Lopinavir/Ritonavir Mylan tablets are swallowed whole and not chewed, broken or crushed.
Slovenian: Pomembno je, da tablete lopinavirja/ritonavirja zaužijete cele in jih ne žvečite, ne lomite in ne drobite.
English: INFORMATION IN BRAILLE Lopinavir/Ritonavir Mylan 200 mg/50 mg
Slovenian: Lopinavir/ritonavir Mylan 200 mg/50 mg
English: UNIQUE IDENTIFIER - 2D BARCODE 2D barcode carrying the unique identifier included
Slovenian: Vsebuje dvodimenzionalno črtno kodo z edinstevno oznako.
English: Lopinavir/ritonavir must not be given to these patients (see section 4.3).
Slovenian: Ti bolniki ne smejo prejeti lopinavirja/ritonavirja (glejte poglavje 4.3).
English: Co administration of ibrutinib and Lopinavir/Ritonavir Mylan should be avoided.
Slovenian: Sočasni uporabi ibrutiniba in zdravila Lopinavir/ritonavir Mylan se je treba izogniti.
English: Effects on drug levels Geometric Mean Change (%) in AUC, Cmax, Cmin Mechanism of interaction
Slovenian: Geometrična srednja sprememba (% ) AUC,
English: Lopinavir/Ritonavir Mylan tablets contain lopinavir and ritonavir, both of which are inhibitors of the P450 isoform CYP3A.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan vsebuje lopinavir in ritonavir, ki zavirata izoobliko CYP3A P450.
English: 3rd Trimester n =
Slovenian: 3. trimesečje n = 23
English: Increased creatine phosphokinase (CPK), myalgia, myositis, and rarely, rhabdomyolysis have been reported with protease inhibitors, particularly in combination with nucleoside reverse transcriptase inhibitors.
Slovenian: Med uporabo zaviralcev proteaz so, zlasti v kombinaciji z nukleozidnimi zaviralci reverzne transkriptaze, poročali o zvišanju kreatin fosfokinaze (CPK), mialgiji, miozitisu in redko o rabdomiolizi.
English: − weight gain.
Slovenian: - Navodilo shranite.
English: Lopinavir - ritonavir:
Slovenian: Vazodilatacijska zdravila bosentan lopinavir - ritonavir:
English: Due to induction of lamotrigine glucuronidation Valproate: ↓
Slovenian: Zaradi indukcije glukuronidacije lamotrigina.
English: Concomitant administration of Lopinavir/Ritonavir Mylan and pimozide is contraindicated as it may increase the risk of serious haematologic abnormalities or other serious adverse effects from this agent (see section 4.3)
Slovenian: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan in pimozida je kontraindicirana, ker lahko poveča tveganje pojava resnih hematoloških nepravilnosti ali drugih resnih neželenih učinkov zaradi tega zdravila (glejte poglavje 4.3).
English: Package leaflet: Information for the user Lopinavir/Ritonavir Mylan 200 mg/50 mg film-coated tablets lopinavir/ritonavir
Slovenian: Navodilo za uporabo: Informacije za uporabnika Lopinavir/ritonavir Mylan 200 mg/50 mg filmsko obložene tablete lopinavir/ritonavir
English: − colchicine (used to treat gout) if you have kidney and/or liver problems (see the section on Other medicines and Lopinavir/Ritonavir); elbasvir/grazoprevir (used to treat chronic hepatitis C virus [HCV]); ombitasvir/paritaprevir/ritonavir with or without dasabuvir (used to treat chronic hepatitis C virus [HCV]);
Slovenian: Fusidno kislino za zdravljenje dolgotrajnih okužb kosti in sklepov se sme uporabljati pod nadzorom zdravnika (glejte poglavje Druga zdravila in zdravilo Lopinavir/ritonavir Mylan); - kolhicin (zdravilo za zdravljenje protina) - če imate težave z ledvicami in/ali jetri (glejte poglavje Druga zdravila in zdravilo Lopinavir/ritonavir Mylan); - elbasvir/grazoprevir (uporablja se za zdravljenje kronične okužbe z virusom hepatitisa C [HCV]); - ombitasvir/paritaprevir/ritonavir z ali brez dasabuvirja (uporablja se za zdravljenje kronične okužbe z virusom hepatitisa C [HCV]); - avanafil ali vardenafil (uporablja se za zdravljenje erektilne disfunkcije); - sildenafil, ki se uporablja za zdravljenje pljučne arterijske hipertenzije (visok krvni tlak v pljučni arteriji).
English: Observed data
Slovenian: DRUGI PODATKI
English: Lopinavir/Ritonavir Mylan must not be administered once daily in combination with amprenavir.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan se ne sme dajati enkrat dnevno v kombinaciji z amprenavirjem.
English: − non-nucleoside reverse transcriptase inhibitors (NNRTIs) (e.g. efavirenz, nevirapine);
Slovenian: Nenukleozidni zaviralci reverzne transkriptaze (NNRTI) efavirenz,
English: − Lopinavir/ritonavir tablets can be taken with or without food.
Slovenian: - Tablete lopinavirja/ritonavirja se lahko jemljejo s hrano ali brez nje.
English: Outcomes at Week 360: Study M97-720
Slovenian: Rezultati v 360.tednu: Študija M97-720 lopinavir/ritonavir (N=100)
English: Steady-state concentrations was moderately decreased due to CYP2C9 and CYP2C19 induction by lopinavir/ritonavir.
Slovenian: Antiepileptiki fenitoin fenitoin: zaradi indukcije CYP2C9 in CYP2C19 z lopinavirjem/ritonavirjem je bila koncentracija v stanju dinamičnega ravnovesja zmerno zmanjšana.
English: Coadministration of Lopinavir/Ritonavir Mylan with tadalafil is not recommended.
Slovenian: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan s tadalafilom ni priporočljiva.
English: Plasma concentrations ↑ Cortisol levels ↓ 86%
Slovenian: Flutikazonpropionat, 50 g intranazalno 4-krat na dan: koncentracija v plazmi ↑ koncentracija kortizola ↓ 86%
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING INNER CARTON OF BLISTER MULTIPACK (WITHOUT BLUE BOX)
Slovenian: PODATKI NA ZUNANJI OVOJNINI VMESNA ŠKATLA SKUPNEGA PAKIRANJA (BREZ MODREGA OKENCA)
English: The selection of resistance to lopinavir in patients having failed prior protease inhibitor therapy was characterised by analysing the longitudinal isolates from 19 protease inhibitor-experienced subjects in 2 Phase II and one Phase III studies who either experienced incomplete virologic suppression or viral rebound subsequent to initial response to lopinavir/ritonavir and who demonstrated incremental in vitro resistance between baseline and rebound (defined as emergence of new mutations or 2-fold change in phenotypic susceptibility to lopinavir).
Slovenian: Pri teh bolnikih se je po uvodnem odzivu na lopinavir/ritonavir pojavila bodisi nepopolna virološka supresija ali virusni preobrat, poleg tega se je pri njih kazala naraščajoča odpornost in vitro med izhodiščem in preobratom (opredeljenim kot pojav novih mutacij ali 2-kratna sprememba fenotipske občutljivosti za lopinavir).
English: Vardenafil:
Slovenian: vardenafil vardenafil:
English: Lopinavir/Ritonavir Mylan 200 mg/50 mg film-coated tablets Each film-coated tablet contains 200 mg of lopinavir co-formulated with 50 mg of ritonavir as a pharmacokinetic enhancer.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan 200 mg/50 mg filmsko obložene tablete Ena filmsko obložena tableta vsebuje 200 mg lopinavirja, v kombinaciji s 50 mg ritonavirja kot farmakokinetičnim ojačevalcem.
English: Delamanid (100 mg BID)
Slovenian: Delaminid (100 mg dvakrat na dan)
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with Lopinavir/Ritonavir Mylan is required.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic ali jeter, ki potrebujejo zdravljenje z zdravilom Lopinavir/ritonavir Mylan, je priporočljivo zmanjšati odmerek kolhicina ali prekiniti zdravljenje s kolhicinom.
English: When co-administered with phenytoin, an increase of Lopinavir/Ritonavir Mylan dosage may be envisaged.
Slovenian: Med sočasno uporabo s fenitoinom je treba predvideti povečanje odmerka zdravila Lopinavir/ritonavir Mylan.
English: Benzodiazepines Midazolam
Slovenian: Peroralni midazolam, triazolam
English: Once-daily dosing: the pharmacokinetics of once daily lopinavir/ritonavir have been evaluated in HIVinfected subjects naïve to antiretroviral treatment.
Slovenian: Farmakokinetiko lopinavirja/ritonavirja enkrat na dan so ocenili pri preiskovancih, okuženih z virusom HIV, ki še niso dobivali protiretrovirusnega zdravljenja.
English: - The active substances are lopinavir and ritonavir - The other ingredients are sorbitan laurate, colloidal anhydrous silica, copovidone, sodium stearyl fumarate, hypromellose, titanium dioxide (E171), macrogol, hydroxypropylcellulose, talc, polysorbate
Slovenian: kopovidon, stearilfumarat, hipromeloza, titanijev dioksid (E171), makrogol, hidroksipropilceluloza, smukec, polisorbat 80.
English: Felodipine, Nifedipine, Nicardipine: Concentrations may be increased due to CYP3A inhibition by lopinavir/ritonavir.
Slovenian: Zaviralci kalcijevih kanalčkov felodipin, nifedipin in nikardipin felodipin, nifedipin in nikardipin: zaradi zavrtja CYP3A z lopinavirjem/ritonavirjem se koncentracija lahko poveča.
English: • No dose adjustment is required for lopinavir/ritonavir during pregnancy and postpartum.
Slovenian: • Med nosečnostjo in po porodu prilagoditev odmerka lopinavirja/ritonavirja ni potrebna.
English: Lopinavir/Ritonavir Mylan 100 mg/25 mg film-coated tablets Each film-coated tablet contains 100 mg of lopinavir co-formulated with 25 mg of ritonavir as a pharmacokinetic enhancer.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan 100 mg/25 mg filmsko obložene tablete Ena filmsko obložena tableta vsebuje 100 mg lopinavirja, v kombinaciji s 25 mg ritonavirja kot famakokinetičnim ojačevalcem.
English: AUC and Cmax ↓ ~50% This effect may be due to induction of bupropion metabolism.
Slovenian: Klinično priporočilo glede sočasne uporabe z zdravilom Lopinavir/ritonavir Mylan bupropion buproprion in njegov aktivni presnovek hidroksibupropion: AUC in Cmax ↓ ~50% To je morda posledica indukcije presnove bupropiona.
English: The effect on DAAs and lopinavir was similar to that observed when lopinavir/ritonavir 400/100 mg BID was administered (see section 4.3).
Slovenian: Učinek na zdravila z direktnim delovanjem na viruse in lopinavir je bil podoben kot pri uporabi lopinavirja/ritonavirja 400/100 mg dvakrat na dan (glejte poglavje 4.3).
English: Dihydroergotamine, ergonovine, ergotamine, methylergonovine
Slovenian: Alkaloidi ergot dihidroergotamin, ergonovin, ergotamin, metilergonovin
English: Concomitant administration of Lopinavir/Ritonavir Mylan and astemizole and terfenadine is contraindicated as it may increase the risk of serious arrhythmias from these agents (see section 4.3).
Slovenian: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan z astemizolom in terfenadinom je kontraindicirana, ker lahko poveča tveganje resnih aritmij zaradi teh zdravil (glejte poglavje 4.3).
English: Erectile dysfunction, menstrual disordersamenorrhoea, menorrhagia
Slovenian: Motnje reprodukcije in dojk pogosti erektilna disfunkcija,menstrualne motnje
English: − Thirst, frequent urination, blurred vision or weight loss as this may indicate raised sugar levels in the blood.
Slovenian: - Žejo, pogosto uriniranje, zamegljen vid ali izgubo telesne mase.
English: Co-administration of lopinavir/ritonavir with rifampicin is not recommended.
Slovenian: Sočasna uporaba lopinavirja/ritonavirja in rifampicina ni priporočljiva.
English: Due to CYP3A inhibition by lopinavir/ritonavir.
Slovenian: Zaradi inhibicije CYP3A z lopinavirjem/ritonavirjem.
English: Oral Midazolam:
Slovenian: Parenteralni midazolam:
English: Read the list of medicines below under ‘Other medicines and Lopinavir/Ritonavir Mylan' for information on certain other medicines which require special care.
Slovenian: Za informacije o drugih zdravilih, ki zahtevajo posebno pozornost, preberite seznam zdravil spodaj v poglavju “Druga zdravila in zdravilo Lopinavir/ritonavir Mylan”.
English: Concomitant administration of Lopinavir/Ritonavir Mylan and cisapride is contraindicated as it may increase the risk of serious arrhythmias from this agent (see section 4.3).
Slovenian: Sočasna uporaba zdravila Lopinavir/ritonavir Mylan in cisaprida je kontraindicirana, saj lahko poveča tveganje resnih aritmij zaradi tega zdravila (glejte poglavje 4.3).
English: Multiple dosing of 800/200 mg lopinavir/ritonavir once daily for 2 weeks without meal restriction (n=16) produced a mean ± SD lopinavir peak plasma concentration (Cmax) of 14.8 ± 3.5 μg/ml, occurring approximately 6 hours after administration.
Slovenian: Lopinavir/ritonavir 800 mg/200 mg so uporabljali v kombinaciji z emtricitabinom 200 mg in tenofovirjem DF 300 mg kot del sheme enkrat na dan. Večkratno odmerjanje Lopinavirja/ritonavirja 800 mg/200 mg enkrat na dan 2 tedna in brez omejevanja obrokov (n = 16) je povzročilo povprečno največjo koncentracijo (Cmax) lopinavirja v plazmi ± SD 14,8 ± 3,5 g/ml, in sicer približno 6 ur po uporabi.
English: Lopinavir: AUC: ↔ Cmin: ↓ 11% Cmax: ↔
Slovenian: AUC: ↔ Cmin: ↓ 11% Cmax: ↔
English: 2nd Trimester n =
Slovenian: 2. trimesečje n = 17*
English: Hypromellose Titanium dioxide (E171) Macrogol
Slovenian: Filmska obloga hipromeloza titanov dioksid (E171) makrogol hidroksipropilceluloza smukec silicijev dioksid, koloidni, brezvodni polisorbat 80
English: Lopinavir/ritonavir is also supplied as 100 mg/25 mg film-coated tablets.
Slovenian: Lopinavir/ritonavir je na voljo tudi kot 100 mg/25 mg filmsko obložene tablete.
English: Lopinavir/ritonavir is also supplied as 200 mg/50 mg film-coated tablets.
Slovenian: Lopinavir/ritonavir je na voljo tudi kot 200 mg/50 mg filmsko obložene tablete.
English: AUC: ↑ 5.9-fold Cmax: ↑ 4.7-fold Due to CYP3A inhibition by lopinavir/ritonavir.
Slovenian: AUC: ↑ 5,9-krat Cmax: ↑ 4,7-krat zaradi zavrtja CYP3A z lopinavirjem/ritonavirjem.
English: Cases of pancreatitis have been reported in patients receiving lopinavir/ritonavir, including those who developed hypertriglyceridaemia.
Slovenian: Pri bolnikih, ki so dobivali lopinavir/ritonavir (vključno s tistimi, pri katerih se je razvila hipertrigliceridemija), so bili opisani primeri pankreatitisa.
English: Caution should be exercised and reduced doses should be considered when Lopinavir/Ritonavir Mylan is co-administered with rosuvastatin (see section 4.4).
Slovenian: Potrebna je previdnost in med sočasno uporabo zdravila Lopinavir/ritonavir Mylan in rosuvastatina pride v poštev uporaba manjših odmerkov (glejte poglavje 4.4).
English: The use of vardenafil with Lopinavir/Ritonavir Mylan is contraindicated (see section 4.3).
Slovenian: Uporaba vardenafila z zdravilom Lopinavir/ritonavir Mylan je kontraindicirana (glejte poglavje 4.3).
English: − medicines affecting the immune system (e.g. cyclosporin, sirolimus (rapamycin), tacrolimus);
Slovenian: (npr. bosentan, riociguat, sildenafil, tadalafil); - zdravila z vplivom na delovanje imunskega sistema (npr. ciklosporin, sirolimus (rapamicin),
English: (Lopinavir/ritonavir 400/100 mg BID)
Slovenian: (lopinavir/ ritonavir 400 mg/100 mg dvakrat na dan)
English: Lopinavir/Ritonavir Mylan 200 mg/50 mg film-coated tablets Approx 18.8 mm x 10.0 mm, white, film coated, ovaloid, biconvex beveled edge tablet debossed with 'MLR3' on one side of the tablet and plain on the other side.
Slovenian: Zdravilo Lopinavir/ritonavir Mylan 200 mg/50 mg filmsko obložene tablete Bela, približno ovalna, bikonvensna filmsko obložena z zglajenim robom, dimenzij približno 18,8 mm x 10,0 mm, z vtisnjeno oznako "MLR3" na eni strani in brez oznake na drugi strani.
English: Oral midazolam, triazolam Increased plasma concentrations of oral midazolam and triazolam.
Slovenian: Večja koncentracija peroralnega midazolama in triazolama v plazmi.
English: Uncommon Atherosclerosis such as myocardial infarction, atrioventricular block, tricuspid valve incompetence
Slovenian: Srčne bolezni občasni ateroskleroza kot je miokardni infarkt, atrioventrikularni blok, motnjedelovanja trikuspidalne zaklopke
English: HCV protease inhibitors Boceprevir 800 mg three times daily
Slovenian: Klinično priporočilo glede sočasne uporabe z zdravilom Lopinavir/ritonavir Mylan boceprevir 800 mg trikrat na dan boceprevir:
English: Lopinavir/Ritonavir Mylan contains sodium
Slovenian: Zdravilo Lopinavir/ritonavir Mylan vsebuje natrij
English: There is no specific antidote for overdose with lopinavir/ritonavir.
Slovenian: Za preveliko odmerjanje lopinavirja/ritonavirja ni specifičnega antidota.