FrancophonIA/ELRC3.0 huggingface dataset:
English: Therefore, EVRA-users must switch to an alternative method of contraception (e.g., progestagen-only contraception or non-hormonal methods) prior to starting therapy with this combination drug regimen.
Croatian: Stoga, korisnice EVRE moraju prijeći na drugu metodu kontracepcije (npr. na kontracepciju samo progestagenom ili na nehormonske metode) prije započinjanja režima liječenja kombinacijom ombitasvir/paritaprevir/ritonavir i dasabuvir.
English: Hypertension Obesity (body mass index over 30 kg/m
Croatian: Pretilost (indeks tjelesne mase iznad 30 kg/m
English: Generalised oedema Oedema peripheral Application site reactions**
Croatian: manje često generalizirani edem periferni edem reakcije na mjestu primjene**
English: Some users may experience amenorrhoea or oligomenorrhoea after discontinuing hormonal contraception, especially when such a condition was pre-existent.
Croatian: U nekih žene može se nakon prestanka hormonske kontracepcije javiti amenoreja odnosno oligomenoreja, posebice ako su takva stanja već bila prisutna.
English: In rare cases, benign liver tumours, and even more rarely, malignant liver tumours have been reported in users of COCs.
Croatian: U rijetkim slučajevima benigni tumori jetre, a još rjeđe maligni tumori, bili su prijavljeni u žena korisnica kombiniranih oralnih kontraceptiva.
English: Short-term
Croatian: Kratkotrajno
English: Users with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation while using EVRA.
Croatian: Žene sklone javljanju kloazme trebaju za vrijeme primjene EVRE izbjegavati izlaganje suncu ili ultraljubičastom zračenju.
English: It is thought that etoricoxib increases ethinyl estradiol levels because it inhibits sulfotransferase activity thereby inhibiting ethinyl estradiol metabolism.
Croatian: Postoji mišljenje da etorikoksib povećava razine etinilestradiola, inhibirajući aktivnost sulfotransferaze, a time i metabolizam etinilestradiola.
English: Third layer polyethylene terephthalate (PET) film polydimethylsiloxane coating.
Croatian: Treći sloj polietilentereftalatni (PET) film polidimetilsiloksanska ovojnica.
English: Long-term
Croatian: Dugotrajno
English: Manufacturer: Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Croatian: Proizvođač: Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgija
English: Factors that increase your risk of a blood clot in a vein The risk of a blood clot with EVRA is small but some conditions will increase the risk.
Croatian: Rizik od krvnog ugruška uz EVRU je mali, ali neka će ga stanja povećati.
English: You may have spotting or light bleeding or breast tenderness or may feel sick during the first 3 cycles.
Croatian: Moguće je tijekom prva 3 ciklusa imati točkasta ili blaga krvarenja, napetost dojki ili mučninu.
English: The disposal label from the outside of the sachet should be peeled open.
Croatian: Naljepnica za odlaganje na vanjskoj strani vrećice mora se do kraja odvojiti.
English: • if you have varicose veins.
Croatian: • ako imate varikozne vene.
English: Only one transdermal patch should be worn at a time.
Croatian: Istodobno treba koristiti samo jedan transdermalni flaster.
English: If the balance of benefits and risks is considered to be negative a CHC should not be prescribed (see section 4.3).
Croatian: Ako se ravnoteža koristi i rizika smatra negativnom, ne smije se propisati kombinirani hormonski kontraceptiv (vidjeti dio 4.3).
English: The active substances are released over 7 days with an average of 203 micrograms norelgestromin and 34 micrograms ethinyl estradiol being released each 24 hours.
Croatian: Djelatne tvari oslobađaju se tijekom 7 dana, a prosječno se oslobađa 203 mikrograma norelgestromina i 34 mikrograma etinilestradiola tijekom 24 sata.
English: What to do if the transdermal patch comes off or partly detaches If the EVRA transdermal patch partly or completely detaches and remains detached, insufficient medicinal product delivery occurs.
Croatian: Ako se EVRA transdermalni flaster djelomično ili potpuno odlijepi i ostane odlijepljen, dolazi do nedostatnog oslobađanja lijeka.
English: • Put it on the buttock, abdomen, upper outer arm or upper back places where it won't be rubbed by tight clothing
Croatian: • Stavite flaster na područje stražnjice, trbuha, vanjskog dijela nadlaktice ili gornji dio leđa - na mjesta na kojima se neće trljati o usku odjeću.
English: How to start EVRA
Croatian: Kako početi primjenjivati EVRU
English: During the transdermal patch-free week a new Change Day may be selected by applying the first EVRA transdermal patch of the next cycle on the first occurrence of the desired day.
Croatian: U tjednu u kojem se transdermalni flaster ne primjenjuje, treba izabrati novi „dan izmjene“, te na željeni dan početi primjenjivati prvi EVRA transdermalni flaster sljedećeg ciklusa.
English: Symptoms of deep vein thrombosis (DVT) can include: - unilateral swelling of the leg and/or foot or along a vein in the leg; - pain or tenderness in the leg which may be felt only when standing or walking; - increased warmth in the affected leg; red or discoloured skin on the leg.
Croatian: Simptomi duboke venske tromboze (DVT) mogu uključivati: - unilateralno oticanje noge i/ili stopala ili oticanje duž vene na nozi; - bol ili osjetljivost noge koja se može osjećati samo pri stajanju ili hodanju; - povećana toplina zahvaćene noge; crvenilo ili promjena boje kože na nozi.
English: Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder: Janssen-Cilag International NV Turnhoutseweg, 30, B-2340 Beerse, Belgium.
Croatian: Nositelj odobrenja za stavljanje lijeka u promet i proizvođač Nositelj odobrenja: Janssen-Cilag International NV Turnhoutseweg 30, B-2340 Beerse, Belgija
English: The metabolites of norelgestromin and ethinyl estradiol are eliminated by renal and faecal pathways.
Croatian: Metaboliti norelgestromina i etinilestradiola eliminiraju se putem bubrega i stolice.
English: - The risk of having a blood clot will vary according to your personal medical history (see “Factors that increase your risk of a blood clot” below).
Croatian: - Rizik od krvnog ugruška može biti različit ovisno o Vašoj osobnoj povijesti bolesti (pogledajte “Čimbenici koji povećavaju
English: Using your fingers, open the foil sachet.
Croatian: Prstima otvorite zaštitnu vrećicu.
English: There is no relevant use of EVRA in children and pre-menarchal adolescents.
Croatian: Nema relevantne primjene lijeka EVRA u djece i adolescentica prije prve menstruacije.
English: Arterial thromboembolism (Acute) myocardial infarction*†
Croatian: Srčani poremećaji rijetko arterijska tromboembolija (akutni) infarkt miokarda*†
English: An increased risk of arterial and venous thrombotic and thrombo-embolic events, including myocardial infarction, stroke, transient ischemic attacks, venous thrombosis and pulmonary embolism has been observed in women using CHCs, which are discussed in more detail in section 4.4.
Croatian: U žena koje koriste kombiniranu hormonsku kontracepciju opažen je povećan rizik od arterijskih i venskih trombotskih i tromboembolijskih događaja, uključujući infarkt miokarda, moždani udar, tranzitorne ishemijske atake, vensku trombozu i plućnu emboliju, o čemu se detaljnije govori u dijelu 4.4.
English: If subsequent EVRA transdermal patch change days are delayed
Croatian: Ako je došlo do kašnjenja dana izmjene EVRA transdermalnog flastera
English: • Do not use this medicine if you are breast-feeding or planning to breast-feed.
Croatian: • Nemojte primjenjivati ovaj lijek ako dojite ili planirate dojiti.
English: • Press down firmly on the patch with the palm of your hand for
Croatian: • Flaster čvrsto pritisnite dlanom na kožu i zadržite pritisak
English: • If you need a blood or urine test, tell your doctor or the laboratory staff that you are taking
Croatian: • Ako morate napraviti pretrage krvi ili mokraće, recite liječniku ili laboratorijskom osoblju da primjenjujete EVRU, jer hormonski kontraceptivi mogu utjecati na neke rezultate pretraga.
English: Positive family history (venous thromboembolism ever in a sibling or parent at relatively early age)
Croatian: Pozitivna obiteljska anamneza (venska tromboembolija u braće, sestara ili roditelja, osobito u relativno ranoj dobi, npr., prije 50. godine).
English: heart attack stroke mini-stroke or temporary stroke-like symptoms, known as a transient ischaemic attack
Croatian: • mali moždani udari ili kratkotrajni simptomi slični simptomima moždanog udara, što se još zove prolazni ishemijski napadaj (TIA)
English: • Put on your next patch on your normal “Patch Change Day”.
Croatian: • Stavite sljedeći flaster na uobičajeni “dan izmjene flastera”.
English: • Non-cancerous (benign) tumours in your breast or liver
Croatian: • dobroćudni (benigni) tumori dojke ili jetre
English: Symptoms of myocardial infarction (MI) can include: - pain, discomfort, pressure, heaviness, sensation of squeezing or fullness in the chest, arm, or below the breastbone; - discomfort radiating to the back, jaw, throat, arm, stomach; - feeling of being full, having indigestion or choking; - sweating, nausea, vomiting or dizziness; - extreme weakness, anxiety, or shortness of breath; - rapid or irregular heartbeats.
Croatian: Simptomi infarkta miokarda mogu uključivati: - bol, nelagodu, pritisak, osjećaj težine, stezanja ili punoće u prsištu, ruci ili iza prsne kosti; - nelagoda koja se širi u leđa, čeljust, grlo, ruku, želudac; - osjećaj punoće, probavne tegobe ili gušenje; - znojenje, mučnina, povraćanje ili omaglica;
English: Factors that increase your risk of a blood clot in an artery It is important to note that the risk of a heart attack or stroke from using EVRA is very small but can increase:
Croatian: Važno je zapamtiti da je rizik od srčanog ili moždanog udara zbog primjene EVRE vrlo mali, ali može se povećati:
English: EVRA is contraindicated if a woman has multiple risk factors that put her at high risk of venous thrombosis (see section 4.3).
Croatian: EVRA je kontraindicirana u žena s većim brojem čimbenika rizika zbog kojih imaju visok rizik od venske tromboze (vidjeti dio 4.3).
English: This makes a total of three weeks with the patches.
Croatian: Sada nosite flaster ukupno tri tjedna.
English: • You must use non-hormonal contraception as back up for one week.
Croatian: • Tjedan dana morate koristiti nehormonsku kontracepciju kao dodatnu metodu zaštite.
English: Non-CHC user (2 events) Levonorgestrel-containing CHC (5-7 events)
Croatian: Kombinirani hormonski kontraceptivi koji sadrže levonorgestrel (5-7 događaja)
English: • You now have a different “Patch Change Day” and a new Day 1.
Croatian: • Sada imate različit “dan promjene flastera” i novi 1. dan.
English: After delivery
Croatian: Nakon poroda
English: • Put on a new patch on your normal “Patch Change Day”, the day after Day 28
Croatian: • Novi flaster stavite na svoj uobičajeni “dan izmjene flastera”, tj. dan nakon 28. dana.
English: Hypercholesterolaemia Fluid retention Increased appetite rare
Croatian: Poremećaji metabolizma i prehrane manje često hiperkolesterolemija retencija tekućine povećan apetit rijetko hiperglikemija* inzulinska rezistencija*
English: Important things to know about combined hormonal contraceptives (CHCs): - They are one of the most reliable reversible methods of contraception if used correctly.
Croatian: • Ako se ispravno primjenjuju, jedna su od najpouzdanijih reverzibilnih metoda kontracepcije.
English: • if you need an operation or if you are off your feet for a long time (see section ‘Blood clots )';
Croatian: • ako morate ići na operaciju ili dugo ležeći mirujete (pogledajte dio „Krvni ugrušci“)
English: • Firmly grasp a corner of the patch and gently take it from the foil sachet
Croatian: • Čvrsto uhvatite kut flastera i pažljivo ga izvucite iz zaštitne vrećice.
English: • if you are very overweight (body mass index or BMI over 30 kg/m
Croatian: • ako ste jako pretili (indeks tjelesne mase ili ITM veći od 30 kg/m2);
English: In case of any doubt, an additional barrier contraceptive method should be used by women on protease inhibitor or non-nucleoside reverse transcriptase inhibitor therapy.
Croatian: U slučaju bilo kakve dvojbe, žene koje se liječe inhibitorom proteaze ili nenukleozidnim inhibitorom reverzne transkriptaze trebaju koristiti dodatnu mehaničku metodu kontracepcije.
English: If therapy starts after the first day of withdrawal bleeding, a non-hormonal contraceptive must be used concurrently for 7 days.
Croatian: Ako primjena započne nakon prvog dana prijelomnog krvarenja, mora se istodobno s flasterom 7 dana koristiti i drugim nehormonskim kontracepcijskim sredstvima.
English: Third layer: polyethylene terephthalate (PET) film, polydimethylsiloxane coating.
Croatian: Treći sloj: polietilentereftalatni (PET) film, polidimetilsiloksanska ovojnica.
English: Very common side effects (may affect more than 1 in 10 women):
Croatian: Vrlo česte nuspojave (mogu se javiti u više od 1 na 10 žena):
English: To prevent interference with the adhesive properties of EVRA, no creams, lotions or powders should be applied to the skin area where the EVRA transdermal patch is to be applied.
Croatian: Na područje kože na koje će se staviti EVRA transdermalni flaster ne smije se nanositi krema, losion ili puder da ne bi utjecali na ljepljivost EVRA flastera.
English: You may experience light or breakthrough bleeding.
Croatian: Možete dobiti blago ili probojno krvarenje.
English: He/she may also talk about whether you need to use another method of contraception.
Croatian: Oni Vam mogu savjetovati kako da lakše mijenjate flaster ili porazgovarati s Vama o potrebi primjene druge metode kontracepcije.
English: Therefore a hepatic tumour should be considered in the differential diagnosis when severe upper abdominal pain, liver enlargement or signs of intra-abdominal haemorrhage occur in women using EVRA.
Croatian: Stoga u slučaju jakih bolova u gornjem dijelu abdomena, povećanja jetre ili znakova intraabdominalnog krvarenja u žena koje koriste EVRU u sklopu diferencijalne dijagnoze treba uzeti u obzir tumor jetre.
English: It is recommended that users visually check their transdermal patch daily to ensure continued proper adhesion.
Croatian: Kako bi se osigurala kontinuirana adhezija transdermalnog flastera, korisnicama se preporučuje svakodnevna vizualna kontrola.
English: How to store EVRA
Croatian: Kako primjenjivati EVRU
English: You may get pregnant if you do not follow these instructions.
Croatian: Ako se ne pridržavate ovih uputa, možete ostati trudni.
English: The breast cancers diagnosed in ever-users tend to be less advanced clinically than the cancers diagnosed in never-users.
Croatian: Karcinom dojke dijagnosticiran u žena koje su u nekom razdoblju života koristile kombinirane oralne kontraceptive obično je klinički manje uznapredovao u odnosu na onaj dijagnosticiran u žena koje nisu nikad koristile kombinirane oralne kontraceptive.
English: * Post-marketing reports.
Croatian: * Prijave nakon stavljanja lijeka u promet.
English: If intercourse has occurred during such an extended pill-free interval, the possibility of pregnancy should be considered.
Croatian: Ako za vrijeme takva produženoga razdoblja bez uzimanja tableta dođe do spolnog odnosa treba misliti o mogućoj posljedičnoj trudnoći.
English: • sudden weakness or numbness of the face, arm or leg,
Croatian: • iznenadna slabost ili obamrlost lica, ruke ili noge, osobito na jednoj strani tijela;
English: • Start your next cycle on your normal “Patch Change Day”, the day after Day 28.
Croatian: • Započnite sljedeći ciklus na uobičajeni “dan izmjene flastera”, tj. prvi dan nakon 28. dana.
English: • If you start more than 4 weeks after delivery, use another non-hormonal contraceptive in addition to this medicine for the first 7 days.
Croatian: • Ako primjenu započnete nakon više od 4 tjedna od poroda, prvih 7 dana dodatno uz ovaj lijek,
English: • Check with your doctor or pharmacist if you are not sure.
Croatian: • Ako niste sigurni, provjerite sa svojim liječnikom ili ljekarnikom.
English: • Breast, cervical or liver cancer
Croatian: • rak dojke, grlića maternice ili jetre
English: Women using a combined hormonal contraceptive pill containing levonorgestrel, norethisterone or norgestimate
Croatian: Žene koje uzimaju kombiniranu hormonsku kontracepciju u tabletama koje sadrže levonorgestrel, noretisteron ili norgestimat oko 5-7 na 10 000 žena
English: When to take special care with EVRA When should you contact your doctor?
Croatian: Kada se trebate obratiti svom liječniku?
English: • if you have elevated levels of fat in the blood (hypertriglyceridaemia) or a positive family history for this condition.
Croatian: • ako imate povišene vrijednosti masnoća u krvi (hipertrigliceridemija) ili ih je imao netko u obitelji.
English: • The amount of hormones you get from EVRA should not be affected by being sick (vomiting)
Croatian: • povraćanje ili proljev ne bi trebali utjecati na količinu hormona koje dobivate iz EVRE.
English: EVRA 203 micrograms/24 hours + 33.9 micrograms/24 hours transdermal patch norelgestromin/ethinyl estradiol
Croatian: EVRA 203 mikrograma/24 sata + 33,9 mikrograma/24 sata transdermalni flaster norelgestromin/etinilestradiol
English: There is now a new “Day 1” and a new “Change Day”.
Croatian: Taj dan je novi „1. dan“ a ujedno i novi „dan izmjene“.
English: Each 20 cm2 transdermal patch contains 6 mg norelgestromin (NGMN) and 600 micrograms ethinyl estradiol (EE).
Croatian: Jedan transdermalni flaster površine 20 cm 2 sadrži 6 mg norelgestromina (NGMN) i 600 mikrograma etinilestradiola (EE).
English: When switching from an oral combined contraceptive Treatment with EVRA should begin on the first day of withdrawal bleeding.
Croatian: Primjenu EVRE treba započeti prvog dana prijelomnog krvarenja.
English: • You have kidney problems.
Croatian: • imate probleme s bubrezima.
English: Breast cancer has been found more often in women who take combined hormonal contraceptives.
Croatian: Rak grlića maternice češće je primjećen u žena koje uzimaju kombinirane hormonske kontraceptive.
English: • Feeling tired or generally unwell
Croatian: • osjećaj umora ili opće loše osjećanje
English: It is estimated that out of 10,000 women who use a low dose CHC that contains levonorgestrel, about 1 will develop a VTE in one year.
Croatian: Procijenjeno je da će od 10 000 žena koje uzimaju nisku dozu KOK-a koji sadrži levonorgestrel, njih pribiližno 6
English: If Cycle 1 therapy starts after first day of the menstrual cycle, a non-hormonal contraceptive should be used concurrently for the first 7 consecutive days of the first treatment cycle only.
Croatian: Ako 1. ciklus primjene flastera započinje nakon prvog dana menstruacijskog ciklusa, potrebno je (samo u tom prvom ciklusu primjene flastera) u prvih 7 uzastopnih dana primjene flastera istodobno se koristiti i drugim, nehormonskim kontracepcijskim sredstvima.
English: EVRA has not been studied in women with renal impairment.
Croatian: EVRA nije bila ispitana u žena s oštećenjem bubrega.
English: Backing layer: low-density pigmented polyethylene outer layer, polyester inner layer.
Croatian: Potporni sloj: vanjski sloj od pigmentiranog polietilena niske gustoće, unutarnji poliesterski sloj.
English: Johnson & Johnson România SRL Str. Tipografilor nr.11 - 15
Croatian: Johnson & Johnson România SRL Str.
English: • You must use back-up contraception for the first week of your new cycle.
Croatian: • Za vrijeme prvog tjedna novog ciklusa morate koristiti dodatnu kontracepciju.
English: If intercourse has occurred during such an extended transdermal patch-free interval, the possibility of pregnancy should be considered.
Croatian: Ako u tom produljenom razdoblju bez transdermalnog flastera dođe do spolnog odnosa, treba misliti o mogućoj trudnoći.
English: Fertility Women may experience a delay in conception following discontinuation of EVRA.
Croatian: Plodnost Nakon prekida primjene EVRE, u žene može doći do odgode začeća.
English: Each consecutive transdermal patch should be applied to a different place on the skin to help avoid potential irritation, although they may be kept within the same anatomic site.
Croatian: Premda se može staviti i na anatomski isto mjesto, svaki sljedeći transdermalni flaster trebalo bi staviti na drugo mjesto na koži, kako bi se izbjeglo potencijalno nadraživanje kože.
English: In women who do not use a CHC and are not pregnant about 2 out of 10,000 will develop a VTE over the period of one year.
Croatian: Približno 2 žene na njih 10 000 koje ne primjenjuju KOK-e i nisu trudne razvit će VTE u razdoblju od godinu dana.
English: Liver cancer
Croatian: Rak jetre
English: • Presence or risk of venous thromboembolism (VTE)
Croatian: • Prisutnost rizika od venske tromboembolije (VTE)
English: • Problems where the patch has been on the skin such as redness, irritation, itching or rash
Croatian: • reakcije na koži na mjestu primjene flastera, kao što su crvenilo, nadraženost, svrbež ili osip
English: • Start a new four week cycle immediately by putting on a new patch.
Croatian: • Odmah započnite novi četverotjedni ciklus primjenom novog flastera.
English: Even more rarely, liver tumours which are cancer have been found.
Croatian: Zloćudni tumori jetre, nađeni su još rjeđe.
English: 1 patch of 20 cm 2 contains: 6 mg norelgestromin and 600 micrograms ethinyl estradiol
Croatian: 1 flaster površine 20 cm 2 sadrži: 6 mg norelgestromina i 600 mikrograma etinilestradiola
English: Each 20 cm2 transdermal patch contains 6 mg norelgestromin and 600 micrograms ethinyl estradiol.
Croatian: Jedan transdermalni flaster od 20 cm2 sadrži 6 mg norelgestromina i 600 mikrograma etinilestradiola.
English: • You weigh 90 kg (which is 14 stone 2 lb) or more;
Croatian: • imate tjelesnu težinu od 90 kg ili veću;
English: You may get irregular, little or no menstruation.
Croatian: Možete imati neredovita ili oskudna krvarenja ili menstruacija može potpuno izostati.
English: Musculoskeletal and connective tissue disorders common
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva često mišićni spazmi
English: 1 patch releases: 203 micrograms norelgestromin and 33.9 micrograms ethinyl estradiol per 24 hours
Croatian: 1 flaster tijekom 24 sata oslobodi: 203 mikrograma norelgestromina i 33,9 mikrograma etinilestradiola
English: These include chlamydia, genital herpes, genital warts, gonorrhoea, hepatitis B, syphilis.
Croatian: Ovaj lijek Vas neće zaštititi od HIV infekcije (SIDA) niti bilo koje druge spolno prenosive bolesti, uključujući klamidiju, genitalni herpes, genitalne bradavice, gonoreju, hepatitis B ili sifilis.
English: What EVRA looks like and contents of the pack EVRA is a thin, beige, plastic transdermal patch stamped “EVRA”.
Croatian: EVRA je tanak plastični transdermalni flaster bež boje s otisnutim nazivom “EVRA”.
English: In rare cases, liver tumours which are not cancer have been found in women taking combined hormonal contraceptives.
Croatian: Dobroćudni tumori jetre, rijetko su nađeni, u žena koje uzimaju kombinirane hormonske kontraceptive.
English: deficiency, protein S deficiency, antithrombin-III deficiency, Factor V Leiden or antiphospholipid antibodies;
Croatian: • ako znate da imate poremećaj koji utječe na zgrušavanje krvi - na primjer, nedostatak proteina C, nedostatak proteina S, nedostatak antitrombina III, faktor V Leiden ili antifosfolipidna protutijela;
English: Eye disorders rare
Croatian: Poremećaji oka rijetko nepodnošenje kontaktnih leća*
English: Middle layer: polyisobutylene/polybutene adhesive, crospovidone, lauryl lactate, non-woven-polyester fabric.
Croatian: Srednji sloj: adheziv od poliizobutilena/polibutena, krospovidon, laurillaktat, netkana poliesterska vlakna.
English: No additional contraceptive is needed.
Croatian: Dodatna kontracepcija nije potrebna.
English: To prevent interference with the adhesive properties of the transdermal patch, no make-up, creams, lotions, powders or other topical products should be applied to the skin area where the transdermal patch is placed or where it will be applied shortly.
Croatian: Šminku, kreme, losione, pudere te ostala sredstva lokalne primjene, ne smije se primjenjivati na mjesto na kojem je ili na mjesto na koje će uskoro biti stavljen transdermalni flaster, kako bi se izbjeglo djelovanje na adhezivna svojstva flastera.