FrancophonIA/ELRC3.0 huggingface dataset:
English: If you take more Capecitabine SUN than you should Contact your doctor as soon as possible before taking the next dose.
Slovenian: Če ste vzeli večji odmerek zdravila Kapecitabin SUN, kot bi smeli Obvestite svojega zdravnika čim prej, preden boste zaužili naslednji odmerek.
English: Your doctor may want you to take a combination of 150 mg and 500 mg tablets for each dose.
Slovenian: Zdravnik vam bo morda predpisal jemanje kombinacije 150 mg in 500 mg tablet pri vsakem odmerku.
English: Contact your doctor immediately if you are concerned about any of the side effects or if you notice any additional side effects not listed in the leaflet (see section 4 Possible side effects).
Slovenian: Nemudoma obvestite svojega zdravnika, če vas skrbi kateri koli od neželenih učinkov ali če opazite kateri koli dodatni neželeni učinek, ki ni naveden v tem navodilu (glejte poglavje 4, Možni neželeni učinki).
English: DPD deficiency: DPD deficiency is a rare condition present at birth that is not usually associated with health problems unless you receive certain medicines.
Slovenian: Pomanjkanje encima dihidropirimidin dehidrogenaze (DPD): pomanjkanje encima DPD je redko prirojeno stanje, ki navadno ne povzroča težav z zdravjem, razen če prejmete določena zdravila.
English: Capecitabine SUN may be used either alone or in combination with other medicines.
Slovenian: Zdravilo Kapecitabin SUN se lahko uporablja samostojno ali v kombinaciji z drugimi zdravili.
English: In the event of grade 2-4 acute toxicity, treatment must be discontinued immediately until observed toxicity resolves.
Slovenian: V primeru akutne toksičnosti stopnje 2-4 je treba zdravljenje nemudoma prekiniti, dokler se opažena toksičnost ne odpravi.
English: Before starting treatment, tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo, vključno z zdravili brez recepta.
English: Dose adjustment for next cycle/dose (% of starting dose)
Slovenian: Prilagoditev odmerka za naslednji cikel/odmerek (% začetnega odmerka)
English: The dose of Capecitabine SUN is based on your body surface area.
Slovenian: Odmerek zdravila Kapecitabin SUN je določen glede na vašo telesno površino.
English: What Capecitabine SUN is and what it is used for
Slovenian: Kaj je zdravilo Kapecitabin SUN in za kaj ga uporabljamo
English: Capecitabine should be permanently discontinued in patients who experience a severe skin reaction during treatment.
Slovenian: Kapecitabin je treba trajno ukiniti pri bolnikih, pri katerih se med zdravljenjem pojavi huda kožna reakcija.
English: - In patients with severe hepatic impairment.
Slovenian: - Pri bolnikih s hudo jetrno okvaro.
English: Do not drive if you feel dizzy, nauseous or tired after taking this medicine.
Slovenian: Ne vozite, če imate po jemanju tega zdravila vrtoglavico, vam je slabo ali ste utrujeni.
English: Rarely, unexpected, severe toxicity (e.g. stomatitis, diarrhoea, neutropenia and neurotoxicity) associated with 5-FU has been attributed to a deficiency of DPD activity.
Slovenian: Redko, nepričakovano, hudo toksičnost (npr. stomatitis, drisko, nevtropenijo in nevrotoksičnost), povezano s 5-FU, pripisujemo pomanjkanju aktivnosti DPD.
English: Dehydration.
Slovenian: Dehidracija.
English: Capecitabine has minor or moderate influence on the ability to drive and use machines.
Slovenian: Kapecitabin ima blag ali zmeren vpliv na sposobnost vožnje in upravljanja s stroji.
English: Only after being absorbed by the body is it changed into an active anti-cancer agent (more in tumour tissue than in normal tissue).
Slovenian: Šele po absorpciji v telesu se spremeni v aktivno citostatično učinkovino (bolj v tumorskem tkivu kot v zdravih tkivih).
English: Cytochrome P-450 2C9 substrates: Other than warfarin, no formal drug-drug interaction studies between capecitabine and other CYP2C9 substrates have been conducted.
Slovenian: Substrati citokroma P-450 2C9: razen z varfarinom, formalnih študij medsebojnega delovanja med kapecitabinom in drugimi substrati CYP2C9 niso izvedli.
English: Creatinine clearance was found to influence the systemic exposure to 5'-DFUR (35% increase in AUC when creatinine clearance decreases by 50%) and to FBAL (114% increase in AUC when creatinine clearance decreases by 50%).
Slovenian: Kreatininski očistek je vplival na sistemsko izpostavljenost 5´-DFUR (35-% povečanje AUC, kreatininski očistek zmanjšan za 50 %) in FBAL (114-% povečanje AUC in padec kreatinskega očistka za 50 %).
English: - Chest pain: if you experience pain localised to the centre of the chest, especially if it occurs during exercise.
Slovenian: - Bolečina v prsnem košu: če občutite bolečino, omejeno na sredino prsnega koša, še posebno, če se pojavi med naporom.
English: Diabetes mellitus or electrolyte disturbances.
Slovenian: Sladkorna bolezen ali elektrolitske motnje.
English: It is therefore possible that Capecitabine SUN could affect your ability to drive a car or operate machines.
Slovenian: Zato je možno, da zdravilo Kapecitabin SUN lahko vpliva na vašo sposobnost za vožnjo in upravljanje s stroji.
English: If caught early, these side effects usually improve within 2 to 3 days after stopping treatment.
Slovenian: Če ukrepamo takoj, neželeni učinki ponavadi minejo v 2 do 3 dneh po prekinitvi zdravljenja.
English: Other side effects seen in this setting are the following:
Slovenian: Drugi neželeni učinki, ki so jih opazili pri tovrstnem zdravljenju so bili naslednji:
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, pyrimidine analogues, ATC code: L01BC06
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe, antimetaboliti, analogi pirimidinskih baz, oznaka ATC: L01BC06
English: What Capecitabine SUN is and what it is used for What you need to know before you take Capecitabine SUN How to take Capecitabine SUN Possible side effects
Slovenian: Kaj je zdravilo Kapecitabin SUN in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Kapecitabin SUN Kako jemati zdravilo Kapecitabin SUN Možni neželeni učinki
English: Body System Very Common All grades
Slovenian: Organski sistem Zelo pogosti Vse stopnje
English: Furthermore, Capecitabine SUN is used to prevent new occurrence of colon cancer after complete removal of the tumour by surgery.
Slovenian: Zdravilo Kapecitabin SUN se uporablja za preprečevanje novega pojava raka debelega črevesa po kompletni odstranitvi tumorja z operacijo.
English: How to store Capecitabine SUN Contents of the pack and other information
Slovenian: Shranjevanje zdravila Kapecitabin SUN Vsebina pakiranja in dodatne informacije
English: There is some evidence that dexpanthenol is effective for hand-foot syndrome prophylaxis in patients treated with capecitabine.
Slovenian: Obstajajo dokazi, da je dekspantenol učinkovit pri preprečevanju sindroma roka-noga pri bolnikih, zdravljenih s kapecitabinom.
English: - During pregnancy and lactation.
Slovenian: - Nosečnost in dojenje.
English: Uncommon Severe and/or Lifethreatening (grade 3-4) or considered medically relevant
Slovenian: Občasni Hudi in/ali življenjsko ogrožajoči (stopnja 3-4) ali klinično pomembni
English: - In patients with severe leukopenia, neutropenia, or thrombocytopenia.
Slovenian: - Pri bolnikih s hudo levkopenijo, nevtropenijo ali trombocitopenijo.
English: Malta/Nederland/Norge/Österreich/Polska/Portugal/ România/Slovenija/Slovenská republika/Suomi/Finland/Sverige Sun Pharmaceutical Industries Europe B.V.
Slovenian: România/Slovenija/Slovenská republika/Suomi/Finland/Sverige Sun Pharmaceutical Industries Europe B.V.
English: - History of severe and unexpected reactions to fluoropyrimidine therapy.
Slovenian: - Hude ali nepričakovane reakcije na zdravljenje s fluoropirimidinom v preteklosti.
English: Two examples are provided here: A person whose body weight is 64 kg and height is 1.64 m has a body surface area of 1.7 m2 and should take 4 tablets of 500 mg and 1 tablet of 150 mg two times daily.
Slovenian: Navedena sta dva primera: oseba, ki tehta 64 kg in je visoka 1,64 m, ima telesno površino 1,7 m2 in mora vzeti 4 tablete po 500 mg in 1 tableto po 150 mg dvakrat na dan.
English: Sorivudine and analogues: a clinically significant drug-drug interaction between sorivudine and 5-FU, resulting from the inhibition of dihydropyrimidine dehydrogenase by sorivudine, has been described.
Slovenian: Sorivudin in analogi: opisali so klinično pomembno medsebojno delovanje med sorivudinom in 5-FU, ki je rezultat sorivudinovega zaviranja dihidropirimidin dehidrogenaze.
English: What you need to know before you take Capecitabine SUN
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Kapecitabin SUN
English: If the calculated creatinine clearance decreases during treatment to a value below 30 ml/min, capecitabine should be discontinued.
Slovenian: Če se izračunani kreatininski očistek med zdravljenjem zmanjša pod 30 ml/min, je treba zdravljenje s kapecitabinom ukiniti.
English: About 3% of the administered dose is excreted in urine as unchanged capecitabine.
Slovenian: Približno 3 % kapecitabina se izločijo nespremenjeni.
English: CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND
Slovenian: D. POGOJI ALI OMEJITVE V ZVEZI Z VARNO IN UČINKOVITO UPORABO
English: Elderly: Based on the population pharmacokinetic analysis, which included patients with a wide range of ages (27 to 86 years) and included 234 (46%) patients greater or equal to 65, age has no influence on the pharmacokinetics of 5'-DFUR and 5-FU.
Slovenian: Starejši bolniki: na osnovi podatkov populacijske farmakokinetične študije, ki je zajela bolnike z velikim razponom v letih (27 do 86 let) in 234 bolnikov (46 %), starih 65 let ali starejših, so ugotovili, da starost ne vpliva na farmakokinetiko 5´-DFUR in 5-FU.
English: CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2) .
Slovenian: B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE Predpisovanje in izdaja zdravila je le s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
English: The capecitabine pivotal studies included females of childbearing potential and males only if they agreed to use an acceptable method of birth control to avoid pregnancy for the duration of the study and for a reasonable period thereafter.
Slovenian: V ključnih študijah z kapecitabinom so sodelovale ženske v rodni dobi in moški, če so se strinjali, da bodo uporabljali sprejemljivo metodo kontracepcije, da bi preprečili nosečnost v času študije in primernem obdobju po njej.
English: Table 9 Key efficacy results for the non-inferiority analysis of study NO16967
Slovenian: Glavni rezultati o učinkovitosti za analizo ne-inferiornosti v študiji NO16967.
English: - In patients with severe renal impairment (creatinine clearance below 30 ml/min).
Slovenian: - Pri bolnikih s hudo ledvično okvaro (očistek kreatinina pod 30 ml/min).
English: - Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 or fluorouracil.
Slovenian: - Preobčutljivost na zdravilno učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1,
English: If you have an unrecognised DPD deficiency and take Capecitabine SUN, you may experience severe forms of the side effects listed under section 4 Possible side effects.
Slovenian: Če ne veste, da imate pomanjkanje DPD in vzamete zdravilo Kapecitabin SUN, lahko izkusite hudo obliko neželenih učinkov, navedenih v poglavju 4, Možni neželeni učinki.
English: Women of childbearing potential/Contraception in males and females Women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with capecitabine.
Slovenian: Ženske v rodni dobi / kontracepcija pri moških in ženskah Ženskam v rodni dobi je treba svetovati naj ne zanosijo, medtem ko se zdravijo s kapecitabinom.
English: België/Belgique/Belgien/България/Česká republika/ Danmark/Eesti/Ελλάδα/Hrvatska/Ireland/Ísland/Κύπρος/ Latvija/Lietuva/Luxembourg/Luxemburg/Magyarország/
Slovenian: België/Belgique/Belgien/България/Česká republika/ Danmark/Eesti/Ελλάδα/Hrvatska/Ireland/Ísland/Κύπρος/ Latvija/Lietuva/Luxembourg/Luxemburg/Magyarország/ Malta/Nederland/Norge/Österreich/Polska/Portugal/
English: Capecitabine SUN belongs to the group of medicines called "cytostatic agents", which stop the growth of cancer cells.
Slovenian: Zdravilo Kapecitabin SUN spada v skupino zdravil, ki jih imenujemo »citostatične učinkovine«, ki zavirajo rast rakavih celic.
English: Recommended posology (see section 5.1):
Slovenian: Priporočeno odmerjanje (glejte poglavje 5.1):
English: Oxaliplatin: no clinically significant differences in exposure to capecitabine or its metabolites, free platinum or total platinum occurred when capecitabine was administered in combination with oxaliplatin or in combination with oxaliplatin and bevacizumab.
Slovenian: Oksaliplatin: klinično pomembnih razlik v izpostavljenosti kapecitabinu ali njegovim presnovkom, prosti platini ali celokupni platini, ni bilo, ko so kapecitabin dajali v kombinaciji z oksaliplatinom ali v kombinaciji z oksaliplatinom in bevacizumabom.
English: Capecitabine can induce severe skin reactions such as Stevens-Johnson syndrome and Toxic Epidermal Necrolysis.
Slovenian: Kapecitabin lahko izzove hude kožne reakcije, kot sta Stevens-Johnsonov sindrom in toksična epidermalna nekroliza.
English: Coumarin-derivative anticoagulation.
Slovenian: Antikoagulantno zdravljenje s kumarinskimi derivati.
English: (neuropathy) - have calcium imbalances (seen in blood tests) - have diabetes - cannot keep food or water in your body because of severe nausea and vomiting - have diarrhoea - are, or become dehydrated - have imbalances of ions in your blood (electrolyte imbalances, seen in tests) - have a history of eye problems as you may need extra monitoring of your eyes - have a severe skin reaction.
Slovenian: (nevropatija) - neravnotežje kalcija (vidno v krvnih testih) - imate sladkorno bolezen - ne morete v sebi zadržati hrane ali tekočine zaradi hude slabosti in bruhanja - imate drisko - ste ali postanete dehidrirani - imate neravnovesje ionov v krvi (elektrolitsko neravnovesje, vidno v testih) - ste v preteklosti imeli bolezni oči, ker boste morda potrebovali dodatne kontrole oči - imate hudo kožno reakcijo.
English: 5 mg/kg IV 30-90 mins Day 1, prior to FOLFOX-4, every 2 weeks
Slovenian: 30-90 min 1. dan, pred FOLFOX-4, vsake 2 tedna
English: - Steven-Johnson syndrome: if you experience painful red or purplish rash that spreads and blisters and/or other lesions begin to appear in the mucous membrane (e.g. mouth and lips), in particular if you had before light sensitivity, infections of the respiratory system (e.g. bronchitis) and/or fever.
Slovenian: - Stevens-Johnsonov sindrom: če dobite boleč rdeč ali škrlaten izpuščaj, ki se širi ali se začnejo pojavljati mehurji in/ali druge poškodbe na sluznici (npr. v ustih in na ustnicah), še posebno, če ste bili občutljivi na svetlobo ali imeli okužbe dihal (npr. bronhitis) in/ali zvišano telesno temperaturo.
English: Patients with known DPD deficiency should not be treated with capecitabine (see section 4.3).
Slovenian: Bolnike z znanim pomanjkanjem DPD ne smemo zdraviti s kapecitabinom (glejte poglavje 4.3).
English: Capecitabine SUN with food and drink You should take Capecitabine SUN no later than 30 minutes after meals.
Slovenian: Zdravilo Kapecitabin SUN skupaj s hrano in pijačo Zdravilo Kapecitabin SUN morate vzeti najpozneje 30 minut po obroku.
English: Antacid: the effect of an aluminium hydroxide and magnesium hydroxide-containing antacid on the pharmacokinetics of capecitabine was investigated.
Slovenian: Antacid: proučevali so vpliv antacida, ki vsebuje aluminijev hidroksid in magnezijev hidroksid, na farmakokinetiko kapecitabina.
English: The incidence of grade 3 or 4 adverse reactions in patients with moderate renal impairment (creatinine clearance 30-50 ml/min) is increased compared to the overall population (see sections 4.2 and 4.3).
Slovenian: Pogostnost pojavov neželenih učinkov stopnje 3 ali 4 pri bolnikih z zmerno ledvično okvaro (očistek kreatinina 30 do 50 ml/min) je v primerjavi s preostalo populacijo povečana (glejte poglavji 4.2 in 4.3).
English: Table 7 Key efficacy results for the non-inferiority analysis of study NO16966
Slovenian: Glavni rezultati o učinkovitosti za analizo ne-inferiornosti v študiji NO16966.
English: - Treatment with sorivudine or its chemically related analogues, such as brivudine (see section 4.5).
Slovenian: - Zdravljenje s sorivudinom ali kemično podobnimi učinkovinami, kot je brivudin (glejte poglavje 4.5).
English: In addition to the above, when Capecitabine SUN is used alone, very common side effects which may affect more than 1 person in 10 are: - abdominal pain - rash, dry or itchy skin - tiredness - loss of appetite (anorexia).
Slovenian: Poleg zgoraj omenjenih neželenih učinkov, se lahko pri samostojni uporabi zdravila Kapecitabin SUN zelo pogosto (pri več kot 1 bolniku od 10) pojavijo naslednji neželeni učinki: - bolečina v trebuhu, - izpuščaj, suha ali srbeča koža, - utrujenost, - izguba apetita (anoreksija).
English: Hypo- or hypercalcaemia.
Slovenian: Hipokalciemija ali hiperkalciemija.
English: You need to be particularly careful if you are taking any of the following: - gout medicines (allopurinol) - blood-thinning medicines (coumarin, warfarin) - certain anti-viral medicines (sorivudine and brivudine) - medicines for seizures or tremors (phenytoin) - a medicine to treat cancer (interferon alpha) - radiotherapy and certain medicines used to treat cancer (folinic acid, oxaliplatin, bevacizumab,
Slovenian: Posebno previdni morate biti pri oporabij: - zdravil proti protinu (alopurinola) - zdravil proti strjevanju krvi (kumarinovi, varfarina) - določenih protivirusnih zdravil (sorivudina in brivudina) - zdravil za preprečevanje epileptičnih napadov ali tremorja (fenitoina) - interferon alfa za zdravljenje raka - radioterapija in določenih zdravil za zdravljenje raka (folinske kisline, oksaliplatina,
English: Other medicines and Capecitabine SUN
Slovenian: Druga zdravila in zdravilo Kapecitabin SUN
English: Alu/Alu blister containing 10 film-coated tablets.
Slovenian: Alu/Alu pretisni omot vsebuje 10 filmsko obloženih tablet.
English: If these side effects continue, contact your doctor immediately.
Slovenian: Če neželeni učinki ne izginejo, takoj pokličite svojega zdravnika.
English: Acute renal failure secondary to dehydration (rare)
Slovenian: akutna ledvična odpoved, ki nastopi zaradi dehidracije (redki)
English: If grade 2 or 3 hand- foot syndrome occurs, administration of capecitabine should be interrupted until the event resolves or decreases in intensity to grade 1.
Slovenian: Če se pojavi sindrom 2. ali 3. stopnje, je treba jemanje kapecitabina prekiniti, dokler simptomi ne ponehajo oziroma se ne zmanjšajo na 1. stopnjo.
English: Day 1, prior to XELOX, every 3 weeks
Slovenian: 30-90 min 1. dan, pred XELOX, vsake 3 tedne
English: Cardiotoxicity.
Slovenian: Kardiotoksičnost.
English: Therefore, capecitabine must not be administered concomitantly with sorivudine or its chemically related analogues, such as brivudine (see section 4.3).
Slovenian: Kapecitabina ne smemo jemati sočasno s sorivudinom ali kemično podobnimi analogi, kot je brivudin (glejte poglavje 4.3).
English: Discontinue permanently or If physician deems it to be in the patient's best interest to continue, interrupt until resolved to grade 0-1
Slovenian: 1. pojav dokončna prekinitev zdravljenja ali če zdravnik meni, da je njegovo nadaljevanje najboljše za bolnika, prekinitev, dokler ni dosežena stopnja
English: Very rare side effects (may affect up to 1 in 10,000 people) include: - severe skin reaction such as skin rash, ulceration and blistering which may involve ulcers of the mouth, nose, genitalia, hands, feet and eyes (red and swollen eyes).
Slovenian: Zelo redki neželeni učinki (pojavijo se lahko pri največ 1 od 10.000 bolnikov) vključujejo: - hude kožne reakcije, kot so kožni izpuščaj, razjede in mehurji, ki lahko vključujejo razjede v ustih, nosu, na spolovilih, rokah, nogah in v očeh (rdeče in zatekle oči).
English: In a drug interaction study with single-dose warfarin administration, there was a significant increase in the mean AUC (+57%) of S-warfarin.
Slovenian: V raziskavi interakcij z zdravili so pri jemanju enkratnega odmerka varfarina ugotovili pomembno povečanje povprečne AUC S-varfarina (+ 57 %).
English: MARKETING AUTHORISATION NUMBER(S) EU/1/13/831/002
Slovenian: - ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/13/831/002
English: In patients with unrecognised DPD deficiency treated with capecitabine, life-threatening toxicities manifesting as acute overdose may occur (see section 4.9).
Slovenian: Pri bolnikih, pri katerih pomanjkanje DPD ni znano in jih zdravimo s kapecitabinom, se lahko pojavijo življensko ogrožujoče toksičnosti, ki se izrazijo kot akutno prekomerno odmerjanje (glejte poglavje 4.9).
English: Table 3 Capecitabine dose reduction schedule (3-weekly cycle or continuous treatment) Toxicity grades*
Slovenian: Shema za zmanjšanje odmerka pri zdravljenju s kapecitabinom (3-tedenski cikli ali neprekinjeno zdravljenje).
English: MARKETING AUTHORISATION NUMBER(S) EU/1/13/831/001
Slovenian: ŠTEVILKA(E) DOVOLJENJA(DOVOLJENJ) ZA PROMET EU/1/13/831/001
English: Table 6 Treatment regimens in study NO16966 (mCRC)
Slovenian: Sheme zdravljenja v študiji NO16966 (metastatski kolorektalni rak).
English: Talk to your doctor before taking Capecitabine SUN, if you - have liver or kidney diseases - have or had heart problems (for example an irregular heartbeat or pains to the chest jaw and back brought on by physical effort and due to problems with the blood flow to the heart) - have brain diseases (for example.
Slovenian: Pred začetkom jemanja zdravila Kapecitabin SUN se posvetujte z zdravnikom, če - imate jetrno ali ledvično bolezen - imate ali ste imeli druge bolezni, kot so težave s srcem (na primer nereden srčni utrip ali bolečine v prsih, čeljusti ali hrbtu, ki se pojavijo zaradi fizičnega napora in problemi s tokom krvi v srce) - imate možgansko bolezen (na primer raka, ki se je razširil na možgane ali poškodbe živčevja
English: ADRs considered by the investigator to be possibly, probably, or remotely related to the administration of capecitabine are listed in table 4 for capecitabine given as a monotherapy and in table 5 for capecitabine given in combination with different chemotherapy regimens in multiple indications.
Slovenian: Neželeni učinki, ki so po mnenju raziskovalca morda, verjetno ali nejasno povezani z jemanjem kapecitabina, so navedeni v preglednici 4 za samostojno zdravljenje s kapecitabinom in v preglednici 5 za dajanje kapecitabina v kombinaciji z različnimi kemoterapijami pri več indikacijah.
English: cisplatin, irinotecan) - medicines used to treat folic acid deficiency.
Slovenian: bevacizumaba, cisplatina, irinotekana) - zdravil za zdravljenje pomanjkanja folne kisline.
English: PRIMARY ANALYSIS XELOX/XELOX+P/ XELOX+BV (EPP*: N=967; ITT**: N=1017)
Slovenian: OSNOVNA ANALIZA XELOX/XELOX + P/ XELOX + BEVACIZUMAB (EPP*: n = 967; ITT**: n = 1.017)
English: - pain in the joints, or in the limbs (extremities), chest or back - fever, swelling in the limbs, feeling ill - problems with liver function (seen in blood tests) and increased blood bilirubin (excreted by the liver).
Slovenian: - bolečino v sklepih ali v okončinah, prsnem košu ali hrbtu, - povišano telesno temperaturo, otekanje okončin, slabo počutje, - težave z delovanjem jeter (ugotovljene pri krvnih preiskavah) in povišan bilirubin v krvi (ki se izloča preko jeter).
English: Capecitabine in combination with docetaxel (see section 5.1) is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy.
Slovenian: Kapecitabin je v kombinaciji z docetakselom (glejte poglavje 5.1) indiciran za zdravljenje bolnikov z lokalno napredovalo ali metastatsko obliko raka dojk po neuspešni citotoksični kemoterapiji.