FrancophonIA/ELRC3.0 huggingface dataset:
English: Jardiance is available as tablets (10 and 25 mg) and can only be obtained with a prescription.
Slovenian: Zdravilo Jardiance je na voljo v obliki tablet (10 in 25 mg), njegovo predpisovanje in izdaja pa je le na recept.
English: For more information about treatment with Jardiance, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Jardiance preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: There was also supportive evidence suggesting benefit when the medicine was combined with insulin.
Slovenian: Zbrali so tudi podporne dokaze, ki kažejo na koristi zdravila Jardiance v kombinaciji z insulinom.
English: Jardiance contains the active substance empagliflozin.
Slovenian: Zdravilo Jardiance vsebuje zdravilno učinkovino empagliflozin.
English: The main measure of effectiveness was the change in the level of a substance in the blood called glycosylated haemoglobin (HbA1c), which gives an indication of how well the blood glucose is controlled, after 24 weeks of treatment.
Slovenian: Glavno merilo učinkovitosti je bila sprememba ravni snovi v krvi, ki se imenuje glikozilirani hemoglobin (HbA1c), kar označuje uspešnost uravnavanja glukoze v krvi po 24 tednih zdravljenja.
English: For the full list of all side effects and restrictions with Jardiance, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov in omejitev pri uporabi zdravila Jardiance glejte navodilo za uporabo.
English: Another main study showed that adding Jardiance to usual treatment reduced adverse cardiovascular (heart and blood vessels) effects.
Slovenian: Druga glavna študija je pokazala, da dodajanje zdravila Jardiance običajnemu zdravljenju znižuje neželene kardiovaskularne učinke (učinke na srce in ožilje).
English: Type 2 diabetes is a disease in which the body does not make enough insulin to control the level of glucose (sugar) in the blood or when the body is unable to use insulin effectively.
Slovenian: Sladkorna bolezen tipa 2 je bolezen, pri kateri telo ne proizvaja dovolj insulina za vzdrževanje primerne ravni glukoze (sladkorja) v krvi ali pri kateri ga telo ne more učinkovito izrabiti.
English: Because Jardiance relies on the working of the kidneys for its effect, treatment with this medicine is not recommended in patients with moderately or severely impaired kidney function.
Slovenian: Ker je učinek zdravila Jardiance odvisen od delovanja ledvic, zdravljenje z njim ni priporočljivo za bolnike z zmerno ali hudo okvaro delovanja ledvic.
English: Jardiance can be used on its own in patients who cannot take metformin (another diabetes medicine).
Slovenian: Zdravilo Jardiance se lahko uporablja kot samostojno zdravilo pri bolnikih, ki ne morejo jemati metformina (drugega zdravila za zdravljenje sladkorne bolezni).
English: Modest but clinically meaningful reductions in HbA1c were also seen when Jardiance was added to other medicines.
Slovenian: Skromno vendar klinično pomembno znižanje ravni HbA1c so zabeležili tudi pri uporabi zdravila Jardiance v kombinaciji z drugimi zdravili.
English: The most common side effect with Jardiance (which may affect more than 1 in 10 people) is hypoglycaemia (low blood sugar) when the medicine is taken with a sulphonylurea or insulin.
Slovenian: Najpogostejši neželeni učinek zdravila Jardiance (ki lahko prizadene več kot 1 osebo od 10) je hipoglikemija (nizka raven sladkorja v krvi), kadar se zdravilo uporablja v kombinaciji s sulfonilsečnino ali insulinom.
English: Jardiance is a diabetes medicine used with diet and exercise to treat adults whose type 2 diabetes is not satisfactorily controlled.
Slovenian: Jardiance je zdravilo za zdravljenje sladkorne bolezni, ki se uporablja skupaj z dieto in telesno vadbo za zdravljenje odraslih, katerih sladkorna bolezen tipa 2 ni zadovoljivo uravnana.
English: For practical information about using Jardiance, patients should read the package leaflet or contact their doctor or pharmacist.
Slovenian: Za praktične informacije o uporabi zdravila Jardiance naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
English: However, the blood glucose lowering effects of the medicine are lower in patients with kidney impairment, and the CHMP recommended that the medicine not be used in some patients, depending on their kidney function.
Slovenian: Vendar je učinek zdravila glede zmanjševanja ravni glukoze v krvi manjši pri bolnikih z okvaro ledvic, zato je CHMP priporočil, da se zdravilo Jardiance pri določenih bolnikih ne uporablja, odvisno od njihovega delovanja ledvic.
English: In addition, the results indicated that Jardiance treatment was associated with a beneficial fall in body weight and blood pressure.
Slovenian: Poleg tega so rezultati pokazali, da je zdravljenje z zdravilom Jardiance povezano s koristnim zmanjšanjem telesne mase in krvnega tlaka.
English: Jardiance was also shown to reduce cardiovascular events in patients with type 2 diabetes who already had cardiovascular disease.
Slovenian: Zabeležili so tudi, da je zdravilo Jardiance zmanjšalo pojavnost kardiovaskularnih dogodkov pri bolnikih s sladkorno boleznijo tipa 2, ki so kardiovaskularno obolenje že imeli.
English: If Jardiance is used in combination with insulin or sulphonylureas (medicines that make the body produce insulin), the doses of these may need to be reduced to decrease the risk of hypoglycaemia (low blood sugar levels).
Slovenian: Če se zdravilo Jardiance uporablja v kombinaciji z insulinom ali sulfonilsečninami (zdravili, ki spodbujajo tvorbo insulina), bo za zmanjšanje tveganja hipoglikemije (nizke ravni sladkorja v krvi) morda treba njihov odmerek zmanjšati.
English: Jardiance was compared with placebo (a dummy treatment) when used alone or added to treatment with other diabetes medicines (metformin, pioglitazone, or metformin plus either pioglitazone or another type of diabetes medicine called a sulphonylurea).
Slovenian: Zdravilo Jardiance so primerjali s placebom (zdravilom brez zdravilne učinkovine), pri čemer so ju uporabili kot samostojni zdravili ali pa dodajali drugim zdravilom za zdravljenje sladkorne bolezni (metforminu, pioglitazonu ali metforminu v kombinaciji s pioglitazonom ali drugim zdravilom za zdravljenje sladkorne bolezni, tj. sulfonilsečnino).
English: concluded that Jardiance was shown to be effective in lowering blood glucose levels in patients with type 2 diabetes, when given alone or in combination with other diabetes medicines with different mechanisms of action.
Slovenian: Zaključil je, da je zdravilo Jardiance učinkovito pri zmanjševanju ravni glukoze v krvi pri bolnikih s sladkorno boleznijo tipa 2, kadar se zdravilo uporablja kot samostojno zdravilo ali v kombinaciji z drugimi zdravili za zdravljenje sladkorne bolezni z drugačnimi mehanizmi delovanja.
English: How does Jardiance work?
Slovenian: Kako zdravilo Jardiance deluje?
English: As blood is filtered by the kidneys, SGLT2 stops glucose in the bloodstream from being passed out into the urine.
Slovenian: Ko se kri filtrira skozi ledvice, SGLT2 prepreči, da bi se glukoza v krvnem obtoku izločala v urin.
English: The active substance in Jardiance, empagliflozin, works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT2).
Slovenian: Zdravilna učinkovina v zdravilu Jardiance, empagliflozin, zavira beljakovino v ledvicah, imenovano natrijev-glukozni koprenašalec 2 (SGLT2 - sodium glucose cotransporter 2).
English: How is Jardiance used?
Slovenian: Kako se zdravilo Jardiance uporablja?
English: By blocking the action of SGLT2, empagliflozin causes more glucose to be removed via the kidney, through the urine, thereby reducing the levels of glucose in the blood.
Slovenian: Empagliflozin z zaviranjem delovanja prenašalca SGLT2 povzroči povečano izločanje glukoze prek ledvic z urinom, kar zniža ravni glukoze v krvi.
English: In addition, beneficial reductions in weight and blood pressure were seen in patients treated with Jardiance.
Slovenian: Poleg tega so pri bolnikih, zdravljenih z zdravilom Jardiance, zabeležili koristno zmanjšanje telesne mase in znižanje krvnega tlaka.
English: Animal studies are insufficient.
Slovenian: Študije na živalih niso zadostne.
English: In some cases you may have to stop using one of the medicines.
Slovenian: V nekaterih primerih boste morda morali nehati jemati eno od teh zdravil.
English: Many feel normal.
Slovenian: Veliko se jih lahko počuti čisto normalno.
English: Elderly (age 65 years or over)
Slovenian: Starejši (stari 65 let ali več)
English: Similar outcomes have been reported with valsartan.
Slovenian: O podobnih izidih so poročali pri valsartanu.
English: • inability to achieve or maintain erection
Slovenian: • nezmožnost doseganja ali ohranjanja erekcije
English: In other patients, one or the other effect may be dominant.
Slovenian: Pri drugih bolnikih lahko en od obeh učinkov prevlada.
English: If you experience this symptom, do not drive or use tools or machines.
Slovenian: Če pride do tega simptoma, ne vozite in ne uporabljajte orodja ali strojev.
English: * See section 4.4 Photosensitivity
Slovenian: * glejte poglavje 4.4 Fotosenzitivnost
English: Some side effects can be serious and need immediate medical attention:
Slovenian: Nekateri neželeni učinki so lahko resni in zahtevajo takojšnjo zdravstveno oskrbo:
English: This is especially important if you are using any of the medicines listed below:
Slovenian: To je še posebej pomembno, če jemljete katero od naslednjih zdravil:
English: Your doctor may need to change the dose or take other precautions.
Slovenian: Zdravnik vam bo morda moral spremeniti odmerek ali upoštevati druge previdnostne ukrepe.
English: The half-life of valsartan is 6 hours.
Slovenian: Razpolovni čas valsartana je približno 6 ur.
English: * Based on patient weight of 50 kg
Slovenian: *temelječ na bolnikovi telesni masi 50 kg
English: Swallow the tablet whole with a glass of water.
Slovenian: Tablete pogoltnite cele, zaužijte jih s kozarcem vode.
English: Do not take a double dose (two tablets at once) to make up for a forgotten tablet.
Slovenian: Ne vzemite dvojnega odmerka (dveh tablet naenkrat), če ste pozabili vzeti prejšnjo tableto.
English: If it is almost time for your next dose you should simply take the next tablet at the usual time.
Slovenian: Če je že skoraj čas za naslednji odmerek, enostavno vzemite naslednjo tableto ob običajnem času.
English: Always take this medicine, even if you are feeling well People who have high blood pressure often do not notice any signs of the problem.
Slovenian: Redno jemljite to zdravilo, tudi če se počutute dobro Ljudje, ki imajo visok krvni tlak, pogosto ne čutijo težav povezanih s tem.
English: If you forget to take a dose of this medicine, take it as soon as you remember and then take the next dose at its usual time.
Slovenian: Če ste pozabili vzeti odmerek tega zdravila, ga vzemite, takoj ko se spomnite in nato vzemite naslednji odmerek ob običajnem času.
English: Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu
English: This reduction in AUC is not, however, accompanied by a clinically significant reduction in the therapeutic effect, and valsartan can therefore be given either with or without food.
Slovenian: Vendar tega zmanjšanja AUC ne spremlja klinično pomembno zmanjšanje terapevtskega učinka, zato je valsartan možno dajati bodisi s hrano ali brez nje.
English: Alcohol, barbiturates or narcotics
Slovenian: alkohol,barbiturati ali narkotiki
English: Use in pregnancy is only recommended when there is no safer alternative and when the disease itself carries greater risk for the mother and foetus.
Slovenian: Uporaba med nosečnostjo je priporočljiva le v primeru, ko ni druge varnejše izbire, in ko bolezen sama predstavlja večje tveganje za mater in plod.
English: You should see your doctor immediately if you experience any of the following symptoms: Common
Slovenian: Takoj morate k zdravniku, če pride do katerega od naslednjih simptomov: pogosti
English: • ringing noise in ears
Slovenian: • zvonjenje v ušesih
English: More than 95% of the absorbed dose is being excreted as unchanged compound in the urine.
Slovenian: Več kot 95 % absorbiranega odmerka se izloči v nespremenjeni obliki z urinom.
English: Absolute bioavailability has been calculated as between 64% and 80%.
Slovenian: Izračunana absolutna biološka uporabnost je med 64 in 80 %.
English: When driving vehicles or using machines it should be taken into account that occasionally dizziness or weariness may occur.
Slovenian: Pri vožnji motornih vozil in uporabi strojev je treba upoštevati, da se občasno lahko pojavi omotica ali utrujenost.
English: Distribution: Volume of distribution is approximately 21 l/kg.
Slovenian: Porazdelitev: Volumen porazdelitve je približno 21 l/kg.
English: Very common: ≥1/10; common: ≥1/100 to <1/10; uncommon: ≥1/1,000 to <1/100; rare: ≥1/10,000 to <1/1,000; very rare: <1/10,000, not known (cannot be estimated from the available data).
Slovenian: Zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000), pogostnost neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: West Sussex, RH12 5AB United Kingdom
Slovenian: West Sussex, RH12 5AB Velika Britanija
English: • sudden, temporary loss of consciousness
Slovenian: • nenadna začasna izguba zavesti
English: D-90429 Nürnberg Germany
Slovenian: D-90429 Nürnberg Nemčija
English: Distribution: The apparent volume of distribution is 4-8 l/kg.
Slovenian: Porazdelitev: Navidezni volumen porazdelitve je 4-8 l/kg.
English: One blister contains 7, 10 or 14 film-coated tablets.
Slovenian: En pretisni omot vsebuje 7, 10 ali 14 filmsko obloženih tablet.
English: All these changes were reversible after a 4-week recovery period and were considered to be exaggerated pharmacological effects.
Slovenian: Vse naštete spremembe so po 4 tednih okrevanja izzvenele in so bile opredeljene kot pretirani farmakološki učinki.
English: Do not stop taking your medecine unless your doctor tells you to.
Slovenian: Ne prenehajte jemati zdravila, razen če vam je tako naročil zdravnik.
English: The combination of these substances has an additive antihypertensive effect.
Slovenian: Kombinacija teh učinkovin ima aditiven antihipertenziven učinek.
English: • sad mood (depression)
Slovenian: • žalostno razpoloženje (depresija)
English: • lack of energy
Slovenian: • pomanjkanje energije
English: Keep your appointments with the doctor even if you are feeling well.
Slovenian: Redno obiskujte zdravnika, tudi če se počutite dobro.
English: The antihypertensive effect persists over 24 hours after administration.
Slovenian: Antihipertenzivni učinek traja več kot 24 ur po uporabi.
English: The clinical significance of this effect is uncertain and not sufficient to preclude their use.
Slovenian: Klinični pomen tega učinka ni jasen in ne zadošča za odsvetovanje uporabe teh zdravil.
English: • increased sensitivity of skin to sun
Slovenian: • povečana občutljivost kože na sončno svetlobo
English: Using other medicines
Slovenian: Uporaba drugih zdravil
English: Depending on how you respond to the treatment, your doctor may suggest a higher or lower dose.
Slovenian: Glede na vaš odziv na zdravilo vam bo zdravnik nato morda svetoval višji ali nižji odmerek.
English: Your doctor will normally advise you to stop taking Imprida HCT before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Imprida HCT.
Slovenian: Zdravnik vam bo praviloma svetoval, da prenehate z jemanjem zdravila Imprida HCT še preden zanosite oziroma takoj, ko ugotovite, da ste noseči in vam bo svetoval jemanje drugega zdravila namesto zdravila Imprida HCT.
English: It is very important that you take this medicine exactly as your doctor tells you to get the best results and reduce the risk of side effects.
Slovenian: Zelo pomembno je, da jemljete to zdravilo natančno tako, kot vam naroči zdravnik, da bodo rezultati zdravljenja kar najboljši, možnost neželenih učinkov pa čim manjša.
English: The clinical translation of these pharmacokinetic variations may be more pronounced in the elderly.
Slovenian: Klinične posledice teh farmakokinetičnih sprememb so lahko izrazitejše pri starejših.
English: This will help you get the best results and lower the risk of side effects.
Slovenian: Tako boste lahko dosegli najboljše uspehe in boste zmanjšali tveganje za neželene učinke.
English: • sugar in the urine
Slovenian: • sladkor v urinu
English: Do not take Imprida HCT if you are more than 3 months pregnant.
Slovenian: Ne jemljite zdravila Imprida HCT če ste noseči več kot 3 mesece.
English: Primary hyperaldosteronism
Slovenian: Primarni hiperaldosteronizem
English: As a result of all three mechanisms, the blood vessels relax and blood pressure is lowered.
Slovenian: Kot posledica vseh treh mehanizmov se krvne žile sprostijo in krvni tlak se zniža.
English: Clinical monitoring and dose adjustment may thus be required.
Slovenian: Morda bo potrebno klinično spremljanje in prilagajanje odmerkov.
English: Imprida HCT was studied in a double-blind, active controlled study in hypertensive patients.
Slovenian: Zdravilo Imprida HCT so proučevali v dvojno slepi, aktivno kontrolirani študiji pri bolnikih s hipertenzijo.
English: The increase in mean AUC is linear and dose proportional in the therapeutic range.
Slovenian: Zvečanje povprečne AUC je linearno in sorazmerno odmerkom v terapevtskem območju.
English: Limited data suggest that the systemic clearance of hydrochlorothiazide is reduced in both healthy and hypertensive elderly subjects compared to young healthy volunteers.
Slovenian: Omejeni podatki kažejo, da je sistemski očistek hidroklorotiazida zmanjšan tako pri zdravih kot pri hipertenzivnih starejših ljudeh v primerjavi z zdravimi prostovoljci.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Imprida HCT in all subsets of the paediatric population in essential hypertension.
Slovenian: Evropska agencija za zdravila je odstopila od obveze za predložitev rezultatov študij z zdravilom Imprida HCT za vse podskupine pediatrične populacije z esencialno hipertenzijo.
English: All of these substances help to control high blood pressure.
Slovenian: Vse tri pomagajo obvladovati visok krvni tlak.
English: • spontaneous bleeding
Slovenian: • spontana krvavitev
English: Systemic exposure to valsartan is slightly elevated in the elderly as compared to the young, but this has not been shown to have any clinical significance.
Slovenian: Sistemska izpostavljenost valsartanu je pri starejših nekoliko povečana v primerjavi z mladimi, vendar se je pokazalo da to nima nobenega kliničnega pomena.
English: This metabolite is pharmacologically inactive.
Slovenian: Presnovek je farmakološko neaktiven.
English: No information is available regarding the use of valsartan and/or amlodipine during breast-feeding.
Slovenian: Ni podatkov o uporabi valsartana in/ali amlodipina med dojenjem.
English: Elimination: Valsartan is primarily eliminated in faeces (about 83% of dose) and urine (about 13% of dose), mainly as unchanged drug.
Slovenian: Izločanje: Valsartan se v prvi vrsti izloči v blato (okrog 83 % odmerka) in urinu (okrog 13 % odmerka), v glavnem v obliki nespremenjenega zdravila.
English: Paediatric patients (age below 18 years) No pharmacokinetic data are available in the paediatric population.
Slovenian: Pediatrični bolniki (starost do 18 let) Farmakokinetičnih podatkov za pediatrično populacijo ni.
English: Mean systemic AUC of valsartan is higher by 70% in the elderly than in the young, therefore caution is required when increasing the dosage.
Slovenian: Povprečna sistemska AUC valsartana je pri starejših za 70 % večja kot pri mladih, zato je pri večanju odmerka potrebna previdnost.
English: The tablets should be swallowed whole with some water, at the same time of the day and preferably in the morning.
Slovenian: Tablete je treba pogoltniti cele, z malo vode, vsak dan ob istem času in sicer najbolje zjutraj.
English: Mean absolute bioavailability is 23%.
Slovenian: Povprečna absolutna biološka uporabnost je 23 %.
English: INTERMEDIATE CARTON OF MULTIPACK (WITHOUT BLUE BOX)
Slovenian: VMESNA ŠKATLA SKUPNEGA PAKIRANJA (BREZ “BLUE BOX” PODATKOV)
English: Do not take together with: lithium (a medicine used to treat some types of depression); medicines or substances that increase the amount of potassium in your blood.
Slovenian: Sočasno ne jemljite: litija (zdravila, ki se uporablja za zdravljenje nekaterih vrst depresij); zdravil ali snovi, ki zvečajo količino kalija v krvi.
English: These could be symptoms of an increase of pressure in your eye and can happen within hours to a week of taking Imprida HCT.
Slovenian: To sta lahko simptoma povečanega tlaka v očesu in se lahko pojavita v nekaj urah do enega tedna jemanja zdravila Imprida HCT.
English: Second and third trimesters of pregnancy (see sections 4.4 and 4.6).
Slovenian: Drugo in tretje trimesečje nosečnosti (glejte poglavji 4.4 in 4.6).
English: The usual dose of Imprida HCT is one tablet per day.
Slovenian: Običajni odmerek zdravila Imprida HCT je ena tableta na dan.
English: • urination at night
Slovenian: • pogosto uriniranje ponoči
English: The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible.
Slovenian: Osnovno zdravljenje predstavlja čim hitrejše prenehanje uporabe hidroklorotiazida.
English: • excessive sweating
Slovenian: • čezmerno znojenje
English: The effect of food on hydrochlorothiazide absorption, if any, has little clinical significance.
Slovenian: Vpliv hrane na absorpcijo hidroklorotiazida, če do njega pride, ima le majhen klinični pomen.
English: Pack sizes: 14, 28, 30, 56, 90, 98 or 280 film-coated tablets.
Slovenian: Velikosti pakiranj: 14, 28, 30, 56, 90, 98 ali 280 filmsko obloženih tablet.
English: Talk to your doctor before drinking alcohol.
Slovenian: Pred uživanjem alkohola se posvetujte s svojim zdravnikom.
English: All changes were considered to be caused by the pharmacological action of valsartan which produces prolonged hypotension, particularly in marmosets.
Slovenian: Vse spremembe so pripisali farmakološkemu učinku valsartana, ki povzroča podaljšano hipotenzijo, še zlasti pri marmozetkah.
English: Absorption: The absorption of hydrochlorothiazide, after an oral dose, is rapid (Tmax about 2 hours).
Slovenian: Absorpcija: Absorpcija hidroklorotiazida po zaužitju je hitra (tmax približno 2 uri).
English: • low blood pressure on standing up
Slovenian: • nizek krvni tlak pri vstajanju
English: Whilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor Antagonists (AIIRAs), similar risks may exist for this class of drugs.
Slovenian: Čeprav ni na voljo kontroliranih epidemioloških podatkov glede tveganja pri uporabi antagonistov angiotenzina II, lahko podobno tveganje obstaja tudi za to skupino zdravil.
English: • CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE IMPOSED ON THE MARKETING AUTHORISATION HOLDER
Slovenian: • POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE, PREDPISANI IMETNIKU DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: It acts selectively on the receptor subtype AT1, which is responsible for the known actions of angiotensin II.
Slovenian: Selektivno deluje na receptorje podvrste AT1, ki so odgovorni za znane učinke angiotenzina II.
English: Patients with hepatic insufficiency have decreased clearance of amlodipine with resulting increase of approximately 40-60% in AUC.
Slovenian: Bolniki z insuficienco jeter imajo znižan očistek amlodipina; posledica je zvišanje AUC za približno 40-60 %.
English: Hypersensitivity reactions to hydrochlorothiazide are more likely in patients with allergy and asthma.
Slovenian: Preobčutljivostne reakcije na hidroklorotiazid so bolj verjetne pri bolnikih z alergijo in astmo.