FrancophonIA/ELRC3.0 huggingface dataset:
English: • Codeine for cough and cold is now contraindicated in children below 12 years, and not recommended in children between 12 and 18 years with compromised respiratory function.
Slovenian: • Kodein för hosta och förkylning är nu kontraindicerat hos barn under 12 år, och rekommenderas inte till barn mellan 12 och 18 år med nedsatt andningsfunktion.
English: • Use of codeine for cough and cold is not recommended in children and adolescents between 12 and 18 years who have breathing problems.
Slovenian: • Användning av kodein för hosta och förkylning rekommenderas inte hos barn och ungdomar som är mellan 12 och 18 år och som har andningsproblem.
English: codeine is not recommended as this population may be more susceptible to breathing problems due to codeine.
Slovenian: • Hos barn och ungdomar mellan 12 och 18 år som har problem med andningen rekommenderas inte kodein eftersom denna population kan vara känsligare för andningsproblem på grund av kodein.
English: Your doctor will check this.
Slovenian: To bo preveril zdravnik.
English: Study results Study GOG-0179
Slovenian: Rezultati študije GOG-0179
English: This means that treatment is not recommended.
Slovenian: To pomeni, da zdravljenje ni priporočljivo.
English: You may need urgent medical treatment:
Slovenian: Morda potrebujete nujno zdravljenje.
English: 3 Extravasation has been reported very rarely.
Slovenian: 3*O ekstravazaciji so poročali zelo redko.
English: Log rank p-value
Slovenian: Log rank p-vrednost
English: In some cases you may need a blood transfusion.
Slovenian: V nekaterih primerih je potrebna transfuzija krvi;
English: Each pack contains 1 vial.
Slovenian: V vsakem pakiranju je 1 viala.
English: Your doctor should dispose of medicines that are no longer required.
Slovenian: Zdravnik bo odstranil zdravilo, ki ga ne potrebujete več.
English: - This treatment cycle will normally be repeated every 3 weeks.
Slovenian: • cikel zdravljenja se običajno ponovi vsake tri tedne.
English: • When new information is received that may impact on the current Safety Specification, Pharmacovigilance Plan or risk minimisation activities
Slovenian: • Po prejemu novih informacij, ki lahko vplivajo na trenutne specifikacije varnosti zdravila, načrt farmakovigilance ali na dejavnosti za zmanjševanje tveganja.
English: If you are pregnant or think you might be pregnant, tell your doctor immediately.
Slovenian: Če ste noseči ali menite, da ste, nemudoma obvestite zdravnika.
English: • Reference to the vial collar as visual reminder of this difference and the instruction that it must not be removed at any time.
Slovenian: • sklic na obroček na viali kot vidni opomnik te razlike ter navodilo, da se ga ne sme nikoli odstraniti;
English: A clear light yellow to orange solution, pH ≤ 1.2.
Slovenian: Bistra, svetlo rumena do oranžna raztopina, pH ≤ 1,2.
English: • Infections (very common) - because Topotecan Eagle may reduce your ability to fight infections.
Slovenian: • Okužbe (zelo pogosto) - ker lahko zdravilo Topotekan Eagle zmanjša vašo sposobnost obrambe
English: Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal medicines.
Slovenian: Obvestite svojega zdravnika, če jemljete ali ste pred kratkim jemali katero koli zdravilo, tudi če ste ga dobili brez recepta, vključno z vsemi zdravili rastlinskega izvora.
English: If this happens, do not drive or use any tools or machines.
Slovenian: V takem primeru ne upravljajte vozil in strojev ter ne uporabljajte orodij.
English: Frequencies are defined as: very common (≥ 1/10), common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000), including isolated reports and not known (cannot be estimated from the available data).
Slovenian: Pogostnost je definirana z izrazi: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000) in zelo redki (< 1/10.000), vključno s posameznimi primeri in ni znano (ni mogoče oceniti na podlagi podatkov, ki so na voljo).
English: • An encouragement of reporting of actual medication errors and any safety events that might be a consequence of a medication error.
Slovenian: • spodbudo k poročanju o dejanskih napakah pri zdravljenju ter vseh varnostnih ukrepih, ki bi bili lahko posledica napake pri zdravljenju;
English: • A form to report medication errors.
Slovenian: • obrazec za poročanje o napakah pri zdravljenju.
English: - if your blood cell count is too low.
Slovenian: • če imate prenizko število krvnih celic.
English: Vials after first opening
Slovenian: Viale po prvem odprtju
English: As per the CHMP Guideline on Risk Management Systems for medicinal products for human use, the updated RMP should be submitted at the same time as the next Periodic Safety Update Report (PSUR).
Slovenian: V skladu s smernicami Odbora za zdravila za uporabo v humani medicini o sistemih za upravljanje tveganja je treba dopolnjen načrt upravljana tveganja predložiti sočasno z naslednjim periodičnim poročilom o varnosti zdravila (PSUR).
English: Vial before opening 18 months.
Slovenian: Viale pred odprtjem 18 mesecev
English: • The risk of medication error due to the higher concentration than the dilution concentration of the originator, with potentially life-threatening consequences.
Slovenian: • navedbe glede tveganja za napačno zdravljenje zaradi večje koncentracije v primerjavi z razredčeno koncentracijo originatorskega zdravila, z možnimi življenjsko nevarnimi posledicami;
English: Do not use Topotecan Eagle if any of the above apply to you.
Slovenian: Zdravila Topotekan Eagle ne uporabite, če kar koli od navedenega velja za vas.
English: - If you have any further questions, ask your doctor or nurse.
Slovenian: • Če imate dodatna vprašanja, se posvetujte z zdravnikom ali medicinsko sestro.
English: Very common - feeling generally weak and tired.
Slovenian: • občutek splošne šibkosti in utrujenosti.
English: The experience in children is limited, therefore no recommendation for treatment of paediatric patients with topotecan can be given (see sections 5.1 and 5.2).
Slovenian: Izkušnje pri otrocih so nezadostne, zato ni mogoče dati priporočil za zdravljenje pediatričnih bolnikov s topotekanom (glejte poglavji 5.1 in 5.2).
English: This should be taken into account when prescribing topotecan, e.g. in case patients at increased risk of tumour bleeds are considered for therapy.
Slovenian: To je treba upoštevati pri predpisovanju topotekana, npr. pri bolnikih, pri katerih obstaja večje tveganje za pojav krvavitve tumorja.
English: The experience of using Topotecan Eagle in children is limited.
Slovenian: Izkušenj z uporabo zdravila Topotekan Eagle pri otrocih je malo.
English: In clinical trials, rash was reported in 4 % of patients and pruritus in 1.5 % of patients.
Slovenian: Med kliničnimi preskušanji so o izpuščaju poročali pri 4 % bolnikov in o pruritusu pri 1,5 % bolnikov.
English: The pharmacokinetics of topotecan given as a 30-minute infusion for 5 days were evaluated in two studies.
Slovenian: Farmakokinetika topotekana, ki so ga dajali v obliki 30-minutne infuzije pet dni, je bila ovrednotena v dveh študijah.
English: Opened on: DD/MM/YY
Slovenian: Odprto dne: DD/MM/LL
English: Metabolism accounts for < 10 % of the elimination of topotecan.
Slovenian: Presnova predstavlja < 10 % izločanja topotekana.
English: Total dose (mg)
Slovenian: Skupni odmerek (mg)
English: Vial before opening 3 years.
Slovenian: Viale pred odprtjem 3 leti
English: Other in-use storage times and conditions are the responsibility of the user.
Slovenian: Za drugačne čas in pogoje shranjevanja pred uporabo je odgovoren uporabnik.
English: Overall recovery of medicinal product-related material following five daily doses of topotecan was 71 to 76 % of the administered intravenous dose.
Slovenian: Celokupno izločanje z zdravilom povezanih snovi po petih dnevnih odmerkih topotekana je bilo od 71 do 76 % intravensko prejetega odmerka.
English: The MAH shall perform the pharmacovigilance activities detailed in the Pharmacovigilance Plan, as agreed in the Risk Management Plan (RMP) presented in Module 1.8.2. of the Marketing Authorisation and any subsequent updates of the RMP agreed by the Committee for Medicinal Products for Human Use (CHMP).
Slovenian: Imetnik dovoljenja za promet z zdravilom bo izvedel študije in farmakovigilančne aktivnosti, podrobno opisane v načrtu farmakovigilance, sprejetem v načrtu za obvladovanje tveganja (RMP), predloženem v modulu 1.8.2 dovoljenja za promet z zdravilom, in vseh nadaljnjih posodobitvah RMP v soglasju z Odborom za zdravila za uporabo v humani medicini (CHMP).
English: The median survival was 30.3 weeks (95 % CI: 27.6, 33.4).
Slovenian: Srednji čas preživetja je bil 30,3 tednov (95 % interval zaupanja: 27,6; 33,4).
English: The user is requested to report any medication errors.
Slovenian: Uporabnike prosimo, naj poročajo o vseh napakah pri zdravljenju.
English: The normal procedures for proper handling and disposal of anticancer medicinal products should be adopted: - Staff should be trained to dilute the medicinal product.
Slovenian: Upoštevati morate običajne postopke za ustrezno ravnanje z zdravili proti raku in njihovo odstranjevanje, in sicer: - Osebje mora biti ustrezno izurjeno za rekonstitucijo zdravila.
English: The topotecan-O-glucuronide and N-desmethyl topotecan-O-glucuronide in the urine were less than 2.0 %.
Slovenian: Topotekan-O-glukuronid in Ndesmetil topotekan-O-glukuronid sta v urinu v manj kot 2,0 %.
English: These may be signs of a drop in the number of your red blood cells (anaemia).
Slovenian: To so lahko znaki zmanjšanja števila rdečih krvnih celic
English: In addition, 5 % of all patients treated (1 % of courses) developed sepsis (see section 4.4).
Slovenian: Poleg tega je pri 5 % vseh zdravljenih bolnikov (1 % ciklov zdravljenja) prišlo do sepse (glejte poglavje 4.4).
English: Overall, the N-desmethyl metabolite contributed a mean of less than 7 % (range 4-9 %) of the total medicinal product related material accounted for in the urine and faeces.
Slovenian: Presnovek N-desmetil predstavlja v povprečju manj kot 7 % (razpon 4-9 %) skupnih z zdravilom povezanih snovi prisotnih v urinu in blatu.
English: This is because Topotecan Eagle can affect the way some other medicines work.
Slovenian: To je potrebno zato, ker lahko zdravilo Topotekan Eagle vpliva na delovanje nekaterih drugih zdravil.
English: The following dosing tables should be used as reference:
Slovenian: Kot referenco uporabite naslednje preglednice odmerjanja:
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 20°C - 25°C and ambient lighting conditions.
Slovenian: Če se ne uporabi takoj, je uporabnik odgovoren za čas in pogoje shranjevanja pred uporabo, pri čemer shranjevanje običajno ni daljše od 24 ur pri 20 °C do 25 °C in običajni osvetlitvi.
English: Chemical and physical in-use stability has been demonstrated for 14 days at 20°C - 25°C when stored in the outer carton to protect from light.
Slovenian: Kemična in fizikalna stabilnost med uporabo sta bili dokazani za 14 dni pri 20 °C do 25 °C, če je zdravilo shranjeno v zunanji ovojnini za zagotovitev zaščite pred svetlobo.
English: Underlying risk factors include history of ILD, pulmonary fibrosis, lung cancer, thoracic exposure to radiation and use of pneumotoxic substances and/or colony stimulating factors.
Slovenian: Med osnovnimi dejavniki tveganja so anamneza IBP, pljučna fibroza, rak pljuč, izpostavljenost prsnega koša obsevanju in uporaba pnevmotoksičnih zdravil in/ali kolonijo stimulirajočih faktorjev.
English: As expected, patients with poor performance status (PS>1) have a lower response rate and an increased incidence of complications such as fever, infection and sepsis (see section 4.8).
Slovenian: Kot je bilo pričakovati, se bolniki v slabšem telesnem stanju (PS > 1) slabše odzivajo na zdravilo in pri njih tudi pogosteje opažamo zaplete, kot so povišana telesna temperatura, okužbe in sepsa (glejte poglavje 4.8).
English: In clinical trials, topotecan was discontinued if the dose had been reduced to 1.0 mg/m2 and a further dose reduction was required to manage adverse effects.
Slovenian: Med kliničnimi preskušanji so topotekan prenehali uporabljati, če je bil odmerek že zmanjšan na 1,0 mg/m2 in bi ga bilo treba zaradi neželenih učinkov še dodatno zmanjšati.
English: Metabolism and nutrition disorders Very common: anorexia (which may be severe)
Slovenian: Presnovne in prehranske motnje Zelo pogosti: anoreksija (ki je lahko huda).
English: In this case, it is used with another medicine called cisplatin.
Slovenian: V tem primeru ga uporabljamo skupaj z drugim zdravilom, imenovanim cisplatin.
English: Accurate assessment of performance status at the time therapy is given is important, to ensure that patients have not deteriorated to performance status 3.
Slovenian: Pomembno je, da se bolnikovo telesno stanje ob začetku zdravljenja natančno oceni in zagotovi, da se ne poslabša na 3.
English: This is because you are more likely to get severe lung problems (interstitial lung disease) when using Topotecan Eagle;
Slovenian: To pomeni, da je verjetnost za pojav hudih težav s pljuči (intersticijska bolezen pljuč) večja, če uporabljate zdravilo Topotekan Eagle;
English: For storage conditions of once-opened and diluted medicinal product, see section 6.3.
Slovenian: Za pogoje shranjevanja po prvem odprtju in redčenju zdravila glejte poglavje 6.3.
English: As with all cytotoxic chemotherapy, effective contraceptive methods must be advised when either partner is treated with topotecan.
Slovenian: Kot velja za vsako citotoksično kemoterapijo, morate svetovati uporabo učinkovite kontracepcijske zaščite, če se kateri od partnerjev zdravi s topotekanom.
English: - Liquid waste may be flushed with large amounts of water.
Slovenian: • Odpadno tekočino lahko sperete z veliko količino vode.
English: Your dose of Topotecan Eagle may need to be adjusted.
Slovenian: Odmerek zdravila Topotekan Eagle bo morda treba prilagoditi.
English: Eagle Laboratories Limited The Clock House Station Approach Marlow, Bucks, SL7 1NT United Kingdom Tel: +1 (201) 326-5324 Fax: +1 (201) 391-2430
Slovenian: Eagle Laboratories Limited The Clock House Station Approach Marlow, Bucks, SL7 1NT Združeno kraljestvo tel.: +1 (201) 326-5324 fax: +1 (201) 391-2430
English: However, as with other cytotoxic medicinal products topotecan is genotoxic and effects on fertility, including male fertility, cannot be excluded.
Slovenian: Ker pa je topotekan - tako kot druga citotoksična zdravilagenotoksičen, ni mogoče izključiti učinkov na plodnost, vključno s plodnostjo samcev.
English: Frequently reported non-haematological effects were gastrointestinal such as nausea (52 %), vomiting (32 %), and diarrhoea (18 %), constipation (9 %) and mucositis (14 %).
Slovenian: Pogostejši nehematološki učinki so bile gastrointestinalne težave, kot so navzea (52 %), bruhanje (32 %), driska (18 %), zaprtje (9 %) in mukozitis (14 %).
English: Contraception in males and females
Slovenian: Kontracepcijska zaščita moških in žensk
English: You should not receive Topotecan Eagle: - if you are allergic (hypersensitive) to topotecan or to any of the other ingredients of this
Slovenian: Zdravila Topotekan Eagle ne smete prejeti: • če ste alergični (preobčutljivi) na topotekan ali katero koli drugo sestavino tega zdravila,
English: Although it is not known whether topotecan is excreted in human breast milk, breast-feeding should be discontinued at the start of therapy.
Slovenian: Čeprav ni znano, če se topotekan izloča v materino mleko, morajo matere ob začetku zdravljenja s topotekanom prenehati dojiti.
English: Like all medicines, Topotecan Eagle can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Topotekan Eagle neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Summary of survival, response rate and time to progression in SCLC patients treated with oral or intravenous topotecan
Slovenian: Povzetek preživetja, deleža odziva in časa do napredovanja pri bolnikih z drobnoceličnim pljučnim rakom, zdravljenih s peroralnim oz. intravenskim topotekanom
English: If you are not sure, talk to your doctor or nurse before using this medicine.
Slovenian: Če ste negotovi, se pred uporabo tega zdravila posvetujte z zdravnikom ali medicinsko sestro.
English: Do not use Topotecan Eagle if you notice any visible particles or if the solution is unclear.
Slovenian: Ne uporabljajte zdravila Topotekan Eagle, če opazite vidne delce ali če je raztopina motna.
English: • The anticipated effects of overdose (e.g. bone marrow suppression).
Slovenian: • pričakovane učinke prevelikega odmerjanja (npr. supresija kostnega mozga);
English: Other severe events occurring in patients that were recorded as related or possibly related to topotecan treatment were anorexia (12 %), malaise (3 %) and hyperbilirubinaemia (1 %).
Slovenian: Drugi hujši učinki, ki so se pojavili pri bolnikih in so jih ocenili kot posledico ali možno posledico zdravljenja s topotekanom, so bili anoreksija (12 %), občutek slabosti (3 %) in hiperbilirubinemija
English: If any of the above apply to you (or you are not sure), talk to your doctor or nurse before using Topotecan Eagle.
Slovenian: Če kar koli od navedenega velja za vas (oz. ste negotovi), se pred uporabo zdravila Topotekan Eagle posvetujte z zdravnikom ali medicinsko sestro.
English: Dilution should be performed under strict aseptic conditions (e.g. an LAF bench).
Slovenian: Redčenje mora potekati v strogo aseptičnih pogojih (na primer na pultu z laminarnim pretokom zraka (LAF)).
English: Anaemia: Moderate to severe (Hb ≤ 8.0 g/dl) in 37 % of patients (14 % of courses).
Slovenian: Anemija: Zmerna do huda (Hb ≤ 8,0 g/dl) pri 37 % bolnikov (14 % ciklov zdravljenja).
English: If you are being treated for cervical cancer, you may get side effects from the other medicine (cisplatin) that you will be given along with Topotecan Eagle.
Slovenian: Če se zdravite zaradi raka materničnega vratu, se lahko pojavijo neželeni učinki zaradi drugega zdravila (cisplatina), ki ga boste prejeli skupaj z zdravilom Topotekan Eagle.
English: If, during topotecan/cisplatin combination therapy serum creatinine exceeds 1.5 mg/dl, it is recommended that the full prescribing information be consulted for any advice on cisplatin dose reduction/continuation.
Slovenian: Če med zdravljenjem s kombinacijo topotekan/cisplatin vrednost serumskega kreatinina preseže 1,5 mg/dl, je priporočljivo pregledati navodila za predpisovanje cisplatina glede kakršnega koli zmanjšanja odmerka cisplatina ali nadaljevanju zdravljenja.
English: Patients should be monitored for pulmonary symptoms indicative of ILD (e.g. cough, fever, dyspnoea and/or hypoxia), and topotecan should be discontinued if a new diagnosis of ILD is confirmed.
Slovenian: Bolnike je treba kontrolirati glede pljučnih simptomov, ki kažejo na IBP (npr. kašelj, povišana telesna temperatura, dispneja in/ali hipoksija); če je diagnoza IBP potrjena, je treba zdravljenje s topotekanom prekiniti.
English: In vitro, topotecan did not inhibit human P450 enzymes CYP1A2, CYP2A6, CYP2C8/9, CYP2C19, CYP2D6, CYP2E, CYP3A, or CYP4A nor did it inhibit the human cytosolic enzymes dihydropyrimidine or xanthine oxidase.
Slovenian: Topotekan in vitro pri človeku ni zaviral delovanja encimov P450 (CYP1A2, CYP2A6, CYP2C8/9, CYP2C19, CYP2D6, CYP2E, CYP3A ali CYP4A).
English: Plasma clearance of total topotecan (active and inactive form) in patients with hepatic impairment only decreased by about 10 % compared with the control group of patients.
Slovenian: Plazemski očistek celotnega topotekana (aktivne in neaktivne oblike) se je pri teh bolnikih v primerjavi s kontrolno skupino zmanjšal le za približno 10 %.
English: Reactions have been mild and have not generally required specific therapy.
Slovenian: Reakcije so bile blage, specifično zdravljenje pa
English: Body surface area (m
Slovenian: Telesna površina (m2)
English: Doses should be similarly reduced if the platelet count falls below 25 x 109/l.
Slovenian: Podobno je odmerke potrebno zmanjšati, če se število trombocitov zmanjša pod 25 x 109/l.
English: How Topotecan Eagle is prepared
Slovenian: Kako se zdravilo Topotekan Eagle pripravi
English: − Personnel should be trained to dilute the medicinal product.
Slovenian: • Osebje mora biti ustrezno izurjeno za rekonstitucijo zdravila.
English: Also some other medicines can affect the way Topotecan Eagle works.
Slovenian: Tudi druga zdravila lahko vplivajo na delovanje zdravila Topotekan Eagle.
English: Among all patients treated in clinical trials (including both those with severe neutropenia and those who did not develop severe neutropenia), 11 % (4 % of courses) developed fever and 26 % (9 % of courses) developed infection.
Slovenian: 11 % vseh bolnikov (4 % ciklov zdravljenja), ki so se zdravili v kliničnih raziskavah (vključno z bolniki s hudo nevtropenijo in s tistimi, pri katerih se nevtropenija ni pojavila), je imelo povišano telesno temperaturo, pri 26 % (9 % ciklov zdravljenja) pa so se pojavile okužbe.
English: In an intravenous population study, the co-administration of granisetron, ondansetron, morphine or corticosteroids did not appear to have a significant effect on the pharmacokinetics of total topotecan (active and inactive form).
Slovenian: V populacijski študiji po intravenski aplikaciji niso zasledili, da bi sočasno dajanje granisetrona, ondansetrona, morfina ali kortikosteroidov pomembneje vplivalo na farmakokinetiko celokupnega topotekana (aktivne in neaktivne oblike).
English: The response rate to topotecan in the combined small cell lung cancer programme (n = 480) for patients with relapsed disease sensitive to first-line therapy, was 20.2 %.
Slovenian: Odstotek odziva na topotekan pri kombiniranem režimu zdravljenja drobnoceličnega pljučnega raka (n = 480) pri bolnikih z relapsom bolezni, dovzetne na zdravljenje s terapijo prve izbire je bil 20,2 %.
English: Topotecan Eagle requires appropriate dilution before use.
Slovenian: Zdravilo Topotekan Eagle je treba pred uporabo ustrezno razredčiti.
English: Pregnancy and breast-feeding - Topotecan Eagle should not be used during pregnancy, unless clearly necessary.
Slovenian: • Zdravila Topotekan Eagle ne smete uporabljati med nosečnostjo, razen če je nujno potrebno.
English: It is important that Topotecan Eagle is further diluted before use (see section 6.6).
Slovenian: Pomembno je, da zdravilo Topotekan Eagle pred uporabo dodatno razredčite (glejte poglavje 6.6).
English: From a microbiological point of view, once opened, the product may be stored for a maximum of 14 days at 20°C - 25°C.
Slovenian: Z mikrobiološkega vidika se lahko odprto zdravilo shranjuje največ 14 dni pri 20 °C do 25 °C.
English: VIAL 5 ml
Slovenian: VIALA 5 ml
English: VIAL 1 ml
Slovenian: VIALA 1 ml
English: Multidose vial: once opened, store for a maximum of 14 days at 20°C-25°C.
Slovenian: Večodmerna viala: po odprtju shranjujte največ 14 dni pri 20 °C do 25 °C.
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency (EMEA) http://www.emea.europa.eu/.
Slovenian: Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/.
English: In dose-finding trials involving 523 patients with relapsed ovarian cancer and 631 patients with relapsed small cell lung cancer, the dose limiting toxicity of topotecan monotherapy was found to be haematological.
Slovenian: Med preskušanji za določitev ustreznega odmerka, v katere je bilo vključenih 523 bolnic z relapsom raka na jajčniku in 631 bolnikov z relapsom drobnoceličnega pljučnega raka, so ugotovili, da pri zdravljenju s topotekanom kot samostojnim zdravilom odmerek omejuje hematološka toksičnost.
English: Red cell transfusions were given in 52 % of patients (21 % of courses).
Slovenian: 52 % bolnikov je prejelo transfuzijo eritrocitov (21 % ciklov zdravljenja).