FrancophonIA/ELRC3.0 huggingface dataset:
English: The following adverse reactions have been reported during clinical studies in adults and/or postmarketing use for CRIXIVAN monotherapy and/or CRIXIVAN with combination antiretroviral therapy (CART).
Slovenian: Med kliničnimi študijami pri odraslih in/ali pri uporabi v obdobju trženja so pri zdravilu CRIXIVAN samem in/ali zdravilu CRIXIVAN ob kombiniranem protiretrovirusnem zdravljenju (CART) poročali o naslednjih neželenih učinkih.
English: Patients with mild-to-moderate hepatic insufficiency due to cirrhosis will require a dose reduction of indinavir due to decreased metabolism of indinavir (see section 4.2).
Slovenian: Bolnikom z blago do zmerno jetrno okvaro zaradi ciroze je treba zmanjšati odmerek indinavirja zaradi zmanjšane presnove indinavirja (glejte poglavje 4.2).
English: Combination of atazanavir with or without ritonavir and Crixivan are not recommended due to increased risk of hyperbilirubinemia (see section 4.4).
Slovenian: Kombinacija atazanavirja z ritonavirjem ali brez skupaj z zdravilom Crixivan ni priporočljiva zaradi povečane nevarnosti hiperbilirubinemije (glejte poglavje 4.4).
English: An increase in hepatic weight occurred in rats treated with indinavir at doses  40 mg/kg/day and was accompanied by hepatocellular hypertrophy at doses  320 mg/kg/day.
Slovenian: Pri podganah, ki so jih zdravili z indinavirjem v odmerkih ≥ 40 mg/kg/dan, je prišlo do povečanja mase jeter, pri odmerkih ≥ 320 mg/kg/dan pa tudi do hepatocelularne hipertrofije.
English: Interaction with indinavir/ritonavir not studied R-warfarin levels may be decreased leading to reduced anticoagulation due to induction of CYP1A2 and CYP2C9 by ritonavir.
Slovenian: Ravni R-varfarina se lahko znižajo, kar povzroči zmanjšano antikoagulacijo zaradi indukcije CYP1A2 in CYP2C9, ki jo povzroča ritonavir.
English: Antiretroviral activity was unaltered when didanosine was administered 3 hours after treatment with indinavir.
Slovenian: Kadar so didanozin dajali tri ure po zdravljenju z indinavirjem, je bila protiretrovirusna dejavnost nespremenjena.
English: • liver problems such as inflammation or liver failure
Slovenian: • težave z jetri, kot so vnetje ali odpoved jeter
English: Sulphamethoxazole/ Trimethoprim 800 mg/160 mg BID (Indinavir 400 mg QID)
Slovenian: Sulfametoksazol/trimetoprim 800 mg/160 mg BID (indinavir 400 mg QID)
English: Indinavir:  (Relative to Indinavir 800 mg SD alone) Didanosine: 
Slovenian: Indinavir:  (glede na samostojno uporabljen 800 mg SD) Didanozin: 
English: Clinical adverse reactions reported by the investigators as possibly, probably, or definitely related to CRIXIVAN in  5 % of patients treated with CRIXIVAN monotherapy or in combination with NRTI(s) (n = 309) for 24 weeks are listed below.
Slovenian: Spodaj so našteti klinični neželeni učinki, o katerih so raziskovalci poročali kot o možno, verjetno ali zagotovo povezanih z zdravilom CRIXIVAN pri ≥ 5% bolnikov (n=309), ki so se 24 tednov zdravili z zdravilom CRIXIVAN samim ali v kombinaciji z NRTI.
English: IMMUNOSUPPRESSIVES Cyclosporine A
Slovenian: IMUNOSUPRESIVNA ZDRAVILA Ciklosporin A
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Pri z virusom HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo se lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART) pojavi vnetna reakcija na asimptomatične ali rezidualne oportunistične okužbe.
English: Marketing Authorisation Holder: Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, The Netherlands
Slovenian: Imetnik dovoljenja za promet z zdravilom: Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, Nizozemska
English: Can be administered without any restrictions with respect to time of administration or food.
Slovenian: Glede na čas uporabe ali hrano se lahko uporablja brez omejitev.
English: Indinavir AUC:  54 % Indinavir Cmin: ↓ 81 % (Relative to Indinavir 800 mg TID alone) Reduction in indinavir concentrations due to induction of medicinal product metabolising and/or transport proteins by St. John's wort.
Slovenian: AUC indinavirja:  54 % Cmin indinavirja: ↓ 81 % (glede na samostojno uporabljen 800 mg TID) Zmanjšanje koncentracij indinavirja zaradi indukcije beljakovin za presnovo zdravila in/ali transportnih beljakovin, ki jo povzroča šentjanževka.
English: ANTIARRTHYMICS Digoxin 0.4 mg SD Ritonavir 200 mg BID
Slovenian: ANTIARITMIKI Digoksin 0,4 mg SD Ritonavir 200 mg BID
English: • phenobarbital, phenytoin, carbamazepine, divalproex, lamotrigine - medicines used to treat fits (epilepsy)
Slovenian: • fenobarbital, fenitoin, karbamazepin, divalproeks, lamotrigin za zdravljenje epileptičnih napadov
English: This medicinal product contains 299.2 mg of lactose in each 800 mg dose (maximum single dose).
Slovenian: Laktoza Vsak 800 mg odmerek (največji enkratni odmerek) zdravila vsebuje 299,2 mg laktoze.
English: • The other ingredients are anhydrous lactose, magnesium stearate, gelatin and titanium dioxide (E 171).
Slovenian: • Druge sestavine zdravila so brezvodna laktoza, magnezijev stearat, želatina in titanov dioksid (E 171).
English: Indinavir AUC:  31 % Indinavir Cmin:  40 %
Slovenian: AUC indinavirja:  31 % Cmin indinavirja:  40 %
English: In HIV-infected paediatric patients, the pharmacokinetic parameters of indinavir in apple sauce were: AUC0-8hr of 26,980 nM*h; peak plasma concentration of 13,711 nM; and plasma concentration at 8 hours post dose of 146 nM.
Slovenian: Pri s HIV okuženih pediatričnih bolnikih so bili farmakokinetični parametri indinavirja v jabolčnem soku naslednji: AUC0-8h 26.980 nM*h, najvišja plazemska koncentracija 13.711 nM, plazemska koncentracija 8 ur po odmerku pa 146 nM.
English: Indinavir AUC:  28 % (Relative to Indinavir 800 mg SD alone) Venlafaxine and active metabolite Odesmethyl-venlafaxine: 
Slovenian: AUC indinavirja:  28 % (glede na samostojno uporabljen 800 mg SD) Venlafaksin in aktivni presnovek O-dezmetilvenlafaksin: 
English: For example, no single substitution or pair of substitutions was capable of engendering measurable ( four-fold) resistance to indinavir, and the level of resistance was dependent on the ways in which multiple substitutions were combined.
Slovenian: Na primer, nobena substitucija sama zase ali par substitucij ni bil sposoben povzročiti merljive (≥ štirikratne) rezistence na indinavir.
English: Amprenavir 600 mg BID AUC ↑ 64 % with 100 mg BID ritonavir alone (relative to amprenavir 1,200 mg BID alone).
Slovenian: AUC amprenavirja 600 mg BID ↑ 64 % s samostojnim ritonavirjem 100 mg BID (glede na samostojni amprenavir 1200 mg BID).
English: Rifabutin AUC: ↑ 173 % Rifabutin Cmin: ↑ 244 % (Relative to rifabutin 300 mg QD alone)
Slovenian: AUC rifabutina: ↑ 173 % Cmin rifabutina: ↑ 244 % (glede na samostojen rifabutin 300 mg QD)
English: If CRIXIVAN is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Slovenian: Če se zdravilo CRIXIVAN daje sočasno s parenteralnim midazolamom, je treba to opraviti na oddelku za intenzivno nego, ob natančnem kliničnem spremljanju morebitne respiratorne depresije in/ali dolgotrajne sedacije.
English: Midazolam is extensively metabolized by CYP3A4.
Slovenian: Midazolam se obsežno presnavlja s CYP3A4.
English: • An example of another medicine that might be given to you, at the same time as CRIXIVAN,
Slovenian: • Primer druge učinkovine, ki vam jo lahko predpišejo istočasno z zdravilom CRIXIVAN, je ritonavir.
English: • buspirone - used to make you calmer
Slovenian: • buspiron - za pomiritev
English: CRIXIVAN is not a cure for HIV.
Slovenian: Zdravilo CRIXIVAN ne pozdravi okužbe z virusom HIV.
English: Store CRIXIVAN in the original bottle and keep the bottle tightly closed to protect it from moisture.
Slovenian: Shranjujte v originalni plastenki, ki jo shranjujte tesno zaprto, za zagotovitev zaščite pred vlago.
English: Eighty antiretroviral naïve patients were entered into a third published study.
Slovenian: V tretjo objavljeno študijo so vključili 80 bolnikov, ki se še niso zdravili s protiretrovirusnimi zdravili.
English: If CRIXIVAN with ritonavir is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Slovenian: Če se zdravilo CRIXIVAN z ritonavirjem daje sočasno s parenteralnim midazolamom, je treba to opraviti na oddelku za intenzivno nego, ob natančnem kliničnem spremljanju morebitne respiratorne depresije in/ali dolgotrajne sedacije.
English: ANTI-INFECTIVES Antiretrovirals Amprenavir
Slovenian: PROTIINFEKCIJSKA ZDRAVILA Protiretrovirusna zdravila Amprenavir
English: Rifabutin AUC*: ↑ 54 % Rifabutin Cmin*: ↑ 99 % (*Relative to rifabutin 300 mg QD alone.
Slovenian: AUC* rifabutina: ↑ 54 % Cmin* rifabutina: ↑ 99 % (* Glede na samostojen rifabutin 300 mg QD.
English: Cyclosporine A dose adjustments should be made according to measured cyclosporine A trough blood levels.
Slovenian: Odmerek ciklosporina A je treba prilagoditi glede na najnižje izmerjene ravni ciklosporina A v krvi.
English: Distribution of indinavir across the placental barrier was significant in rats, but limited in rabbits.
Slovenian: Indinavir je znatno prehajal skozi posteljico podgan, toda omejeno skozi posteljico kuncev.
English: Viral load remained < 200 copies/mL for 48 weeks in all patients.
Slovenian: Količina virusov po 48-ih tednih je bila pri vseh bolnikih še vedno < 200 kopij/ml.
English: How to take CRIXIVAN
Slovenian: Kako jemati zdravilo CRIXIVAN
English: Preliminary clinical data suggest that CRIXIVAN 400 mg in combination with ritonavir 100 mg, both administered orally twice daily, may be an alternative dosing regimen (see section 5.2).
Slovenian: Preliminarni klinični podatki kažejo, da je lahko alternativni režim odmerjanja zdravilo CRIXIVAN 400 mg peroralno dvakrat na dan v kombinaciji z ritonavirjem 100 mg peroralno dvakrat na dan (glejte poglavje 5.2).
English: ORAL CONTRACEPTIVES Norethindrone/ethinyl estradiol 1/35 1 mcg QD (Indinavir 800 mg TID)
Slovenian: PERORALNI KONTRACEPTIVI Noretindron/etinilestradiol 1/35 1 mikrogramov QD (indinavir 800 mg TID)
English: • Two 400 mg capsules (800 mg) - taken three times a day (every 8 hours).
Slovenian: • Dve 400 mg kapsuli (800 mg) - vzeti trikrat na dan (vsakih 8 ur).
English: A dose reduction of indinavir to 600 mg every 8 hours should be considered when administering itraconazole or ketoconazole concurrently (see section 4.5).
Slovenian: Pri sočasni uporabi itrakonazola ali ketokonazola je treba razmisliti o zmanjšanju odmerka indinavirja na 600 mg vsakih 8 ur (glejte poglavje 4.5).
English: In addition, indinavir with ritonavir must not be administered with alfuzosin, meperidine, piroxicam, propoxyphene, bepridil, encainide, flecanide, propafenone, quinidine, fusidic acid, clozapine, clorazepate, diazepam, estazolam and flurazepam.
Slovenian: Poleg tega se indinavir v kombinaciji z ritonavirjem ne sme dajati skupaj z alfuzosinom, meperidinom, piroksikamom, propoksifenom, bepridilom, enkainidom, flekanidom, propafenonom, kinidinom, fusidno kislino, klozapinom, klorazepatom, diazepamom, estazolamom in flurazepamom.
English: Inhibition of CYP3A4 by both CRIXIVAN and ritonavir could result in elevated plasma concentrations of these medicines, potentially causing serious or life-threatening reactions (see section 4.5).
Slovenian: Inhibicija CYP3A4 z zdravilom CRIXIVAN in ritonavirjem lahko povzroči povečano koncentracijo teh zdravil v plazmi, kar lahko povzroči resne smrtno nevarne reakcije (glejte poglavje 4.5).
English: Inhibition of CYP3A4 by both CRIXIVAN and ritonavir could result in elevated plasma concentrations of these medicines, potentially causing serious or life-threatening reactions.
Slovenian: Inhibicija CYP3A4 z zdravilom CRIXIVAN in ritonavirjem lahko povzroči povečano koncentracijo teh zdravil v plazmi, kar lahko povzroči resne življenjsko nevarne reakcije.
English: The following side effects have been reported by patients taking CRIXIVAN:
Slovenian: Pri bolnikih, ki so jemali zdravilo CRIXIVAN, so poročali o naslednjih neželenih učinkih:
English: Safety in patients with impaired renal function has not been studied; however, less than 20 % of indinavir is excreted in the urine as unchanged medicinal product or metabolites (see section 4.4).
Slovenian: Varnosti pri bolnikih z okvarjeno ledvično funkcijo niso preučevali, vendar se z urinom izloči manj kot 20 % indinavirja, nespremenjenega ali v obliki presnovkov (glejte poglavje 4.4).
English: Nephrolithiasis occurred in approximately 10 % of patients treated with the recommended (unboosted) dose of CRIXIVAN in a pooled analysis of controlled clinical trials (see also below table and in section 4.4).
Slovenian: V združeni analizi nadzorovanih kliničnih preskušanj so se ledvični kamni pojavili pri približno 10 % bolnikov, zdravljenih s priporočenim (neokrepljenim) odmerkom zdravila Crixivan (glejte tudi spodnjo preglednico in poglavje 4.4).
English: Amlodipine 5 mg QD (Indinavir/ritonavir 800/100 BID)
Slovenian: Amlodipin 5 mg QD (indinavir/ritonavir 800/100 BID)
English: Zidovudine/Lamivudine 200/150 mg TID (Indinavir 800 mg TID)
Slovenian: Zidovudin/lamivudin 200/150 mg TID (indinavir 800 mg TID)
English: Safety in patients with impaired renal function has not been studied; however, less than 20 % of indinavir is excreted in the urine as unchanged medicinal product or metabolites (see section 4.2).
Slovenian: Varnosti uporabe pri bolnikih z okvarjeno ledvično funkcijo niso preučili, vendar se z urinom izloči manj kot 20 % indinavirja, nespremenjenega ali v obliki presnovkov (glejte poglavje 4.2).
English: SEDATIVES/HYPNOTICS Midazolam (parenteral)
Slovenian: POMIRJEVALA/USPAVALA Midazolam (parenteralni)
English: If you take more CRIXIVAN than you should, talk to your doctor as soon as possible.
Slovenian: Če ste vzeli večji odmerek zdravila CRIXIVAN, kot bi smeli Če ste vzeli večji odmerek zdravila CRIXIVAN, kot bi smeli, se čimprej posvetujte z zdravnikom.
English: - rifampicin - an antibiotic used to treat infections - cisapride - used for gut problems - amiodarone - used for heart rhythm problems - pimozide - used for some mental health problems - lovastatin or simvastatin - used to lower cholesterol - St. John's wort (Hypericum perforatum) - a herbal medicine used for depression - ergot tartramine (with or without caffeine) - used for migraines - astemizole or terfenadine - antihistamines used for hay fever and other allergies - quetiapine - used for some mental illnesses such as schizophrenia, bipolar disorder and major depressive disorder - alprazolam, triazolam and midazolam (by mouth) - used to make you calmer or help you sleep.
Slovenian: - rifampicin - antibiotik, ki se uporablja za zdravljenje okužb - cisaprid - uporablja se pri črevesnih težavah - amiodaron - uporablja se pri težavah s srčnim ritmom - pimozid - uporablja se pri nekaterih mentalnih zdravstvenih težavah - lovastatin ali simvastatin - uporabljata se za zniževanje holesterola - šentjanževko (Hypericum perforatum) - rastlinski pripravek za zdravljenje depresije - ergot tartramin (z ali brez kofeina) - uporablja se za migreno - astemizol ali terfenadin - antihistaminika za zdravljenje senenega nahoda in drugih alergij - kvetiapin - uporablja se za zdravljenje nekaterih duševnih bolezni, kot so shizofrenija,
English: • bone problems - signs include stiff joints, aches and pains, especially of the hip and difficulty moving.
Slovenian: • težave s kostmi - znaki vključujejo togost sklepov, bolečnost in bolečine v sklepih, zlasti v kolku in težave z gibljivostjo.
English: Pharmacokinetic analysis in one study was performed on nineteen of the patients, with a median (range) indinavir AUC 0-12hr, Cmax, and Cmin of 25,421 nM*h (21,489 - 36,236 nM*h), 5,758 nM (5,056 - 6,742 nM) and 239 (169 - 421 nM), respectively.
Slovenian: Analizo farmakokinetike v eni študiji so opravili pri 19-ih bolnikih, pri katerih je bila mediana (razpon) AUC0-12 h indinavirja 25421 nM*h (21489-36236 nM*h), Cmax 5758 nM (5056-6742 nM) in Cmin 239 (169-421 nM).
English: The most commonly reported symptoms were gastro-intestinal (e.g., nausea, vomiting, diarrhoea) and renal (e.g., nephrolithiasis, flank pain, haematuria).
Slovenian: Simptomi, o katerih so najpogosteje poročali, so bili prebavni (npr. navzea, bruhanje, driska) in ledvični (npr. ledvični kamni, bolečina v ledvenem predelu, hematurija).
English: ANTIDEPRESSANTS Venlafaxine 50 mg TID (Indinavir 800 mg SD)
Slovenian: ANTIDEPRESIVI Venlafaksin 50 mg TID (indinavir 800 mg SD)
English: In one study, at week 24, the proportion of patients with plasma viral RNA below 400 copies/mL was 60 %; the mean increase in CD4 cell counts was 242 cells/mm
Slovenian: V eni raziskavi je bil v 24. tednu delež bolnikov z vrednostjo virusne RNA v plazmi pod 400 kopij/ml 60 %, povprečno povečanje števila CD4 celic 242 celic/mm
English: • Four 200 mg capsules (800 mg) - taken three times a day (every 8 hours).
Slovenian: • Štiri 200 mg kapsule (800 mg) - vzete trikrat na dan (vsakih 8 ur).
English: In general, these events were not associated with renal dysfunction and resolved with hydration and temporary interruption of therapy (e.g., 1-3 days).
Slovenian: Izboljšanje so dosegli z zadostno preskrbo s tekočino in začasno prekinitvijo zdravljenja (npr. za 1-3 dni).
English: At week 24, the proportion of patients with plasma viral RNA below 400 copies/mL was 60 %.
Slovenian: V 24. tednu je bil delež bolnikov z vrednostjo virusne RNA v plazmi pod 400 kopij/ml 60 %.
English: Each hard capsule contains indinavir sulphate corresponding to 200 mg of indinavir.
Slovenian: Ena trda kapsula vsebuje indinavirjev sulfat, ki ustreza 200 mg indinavirja.
English: You usually take less CRIXIVAN if you are also taking ritonavir.
Slovenian: Če jemljete tudi ritonavir, boste običajno vzeli manj zdravila CRIXIVAN.
English: • stomach pain or swelling
Slovenian: • bolečine v želodcu ali otekanje
English: Diltiazem AUC0-24hr:  43 % Indinavir/ritonavir AUCs: 
Slovenian: AUC0-24 h diltiazema:  43 % AUCS indinavirja/ritonavirja: 
English: Due to CYP3A inhibition by indinavir, concentrations of quetiapine are expected to increase.
Slovenian: Ker indinavir zavira CYP3A, se pričakuje povečanje koncentracije kvetiapina.
English: This proportion tends to remain stable over prolonged periods of follow-up.
Slovenian: Po daljšem obdobju spremljanja ta delež stremi k stalni vrednosti.
English: • CRIXIVAN - one 400 mg capsules (400 mg) - taken twice a day.
Slovenian: • Zdravilo CRIXIVAN - ena 400 mg kapsula (400 mg) - vzeta dvakrat na dan.
English: In the intent to treat and on treatment analyses the proportion of patients with HIV RNA of < 50 copies/mL was 68.8 % and 88.7 %, respectively, at week 96.
Slovenian: V analizi populacije, ki so jo nameravali zdraviti, je imelo HIV RNA < 50 kopij/ml po 96. tednu 68,8 % bolnikov, v populaciji, ki se je zdravila, pa 88,7 % bolnikov.
English: • kidney problems such as kidney infection, worsening or loss of kidney function
Slovenian: • težave z ledvicami, kot so vnetje, oslabljeno delovanje ali prenehanje delovanja ledvic
English: Interaction with indinavir/ritonavir not studied
Slovenian: Medsebojnega delovanja z indinavirjem/ritonavirjem niso preučevali.
English: • darkening skin colour
Slovenian: • potemnitev kože
English: Each hard capsule contains indinavir sulphate corresponding to 400 mg of indinavir.
Slovenian: Ena trda kapsula vsebuje indinavirjev sulfat, kar ustreza 400 mg indinavirja.
English: Not studied, combined administration may result in increased warfarin levels.
Slovenian: Kombinirana uporaba lahko povzroči zvišane ravni varfarina.
English: CRIXIVAN with or without ritonavir should not be administered concurrently with amiodarone, terfenadine, cisapride, astemizole, quetiapine, alprazolam, triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5), pimozide, ergot derivatives, simvastatin or lovastatin (see section 4.4).
Slovenian: Zdravilo CRIXIVAN se v kombinaciji z ritonavirjem ali brez njega ne sme dajati sočasno z amiodaronom, terfenadinom, cisapridom, astemizolom, kvetiapinom, alprazolamom, triazolamom, peroralnim midazolamom (za previdnost pri parenteralnem midazolamu glejte poglavje 4.5), pimozidom, derivati rženega rožička, simvastatinom ali lovastatinom (glejte poglavje 4.4).
English: Caution must also be exercised if indinavir is used concurrently with atorvastatin.
Slovenian: Previdnost je potrebna tudi pri sočasni uporabi indinavirja in atorvastatina.
English: Interactions and dose recommendations with other medical products - UNBOOSTED INDINAVIR
Slovenian: Tabela 1: Medsebojno delovanje in priporočeni odmerki z drugimi zdravili - NEOKREPLJEN INDINAVIR (brez ritonavirja)
English: The combination of rifampicin and CRIXIVAN with concomitant low-dose ritonavir is contraindicated (see section 4.3).
Slovenian: Kombinacija rifampicina in zdravila CRIXIVAN skupaj z nizkim odmerkom ritonavirja je kontraindicirana (glejte poglavje 4.3).
English: Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered.
Slovenian: Razmisliti je treba o zmanjšanju odmerka zdravila CRIXIVAN na 600 mg na vsakih 8 ur.
English: Indinavir AUC: 25 % Indinavir Cmin ↓ 50 % (Relative to Indinavir/ritonavir 800/100 BID alone)
Slovenian: AUC indinavirja:  25 % Cmin indinavirja: ↓ 50 % (glede na samostojni indinavir/ritonavir 800/100 BID)
English: There are no interaction data available on the coadministration of indinavir/ritonavir and amprenavir.
Slovenian: Podatkov o medsebojnem delovanju pri sočasni uporabi indinavirja/ritonavirja in amprenavirja ni.
English: Indinavir AUC: ↔
Slovenian: AUC indinavirja: ↔
English: • CRIXIVAN - two 200 mg capsules (400 mg) - taken twice a day.
Slovenian: • Zdravilo CRIXIVAN - dve 200 mg kapsuli (400 mg) - vzeti dvakrat na dan.
English: • The capsules are printed with printing ink containing titanium dioxide (E 171), indigo carmine (E 132) and iron oxide (E 172).
Slovenian: • Kapsule so potiskane s tiskarskim črnilom, ki vsebuje titanov dioksid (E 171), indigo karmin (E 132) in železov oksid (E 172).
English: Limited data are available on the pharmacokinetics of indinavir in association with low dose ritonavir.
Slovenian: Podatki o farmakokinetiki indinavirja v kombinaciji z majhnim odmerkom ritonavirja so omejeni.
English: CALCIUM CHANNEL BLOCKERS Diltiazem 120 mg QD (Indinavir/ritonavir 800/100 BID)
Slovenian: BLOKATORJI KALCIJEVIH KANALČKOV Diltiazem 120 mg QD (indinavir/ritonavir 800/100
English: • pain on urination
Slovenian: • boleče uriniranje
English: nephrolithiasis, in some cases with renal insufficiency or acute renal failure; pyelonephritis, interstitial nephritis, sometimes associated with indinavir crystal deposits.
Slovenian: hematurija, proteinurija, kristalurija ledvični kamni, disurija ledvični kamni, v nekaterih primerih z ledvično okvaro ali akutno ledvično odpovedjo, pielonefritis, intersticijski nefritis, včasih povezan z nalaganjem kristalov indinavirja.
English: Methadone AUC and Cmin: 
Slovenian: AUC in Cmin metadona: 
English: Indinavir inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of these anticonvulsants.
Slovenian: Indinavir zavira CYP3A4, zato se pričakuje, da bo povečal koncentracije teh antikonvulzivov v plazmi.
English: Musculoskeletal and connective tissue disorders
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti neznana*
English: If you are not sure, talk to your doctor, pharmacist or nurse before taking CRIXIVAN.
Slovenian: Če niste prepričani, se pred začetkom jemanja zdravila CRIXIVAN posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Synergistic antiretroviral activity was observed when human T-lymphoid cells infected with the LAI variant of HIV-1 were incubated with indinavir and either zidovudine, didanosine, or NNRTIs.
Slovenian: Človeške T-limfoidne celice, okužene z LAI različico HIV-1, so inkubirali z indinavirjem v kombinaciji z zidovudinom, didanozinom ali NNRTI-ji in opazili sinergistično protiretrovirusno delovanje.