FrancophonIA/ELRC3.0 huggingface dataset:
English: The tablets should not be chewed or crushed.
Slovenian: Tablet se ne sme žvečiti ali drobiti.
English: Afinitor may affect the way some other medicines work.
Slovenian: Zdravilo Afinitor lahko vpliva na delovanje nekaterih drugih zdravil.
English: In this case, a dose of 2.5 mg daily must not be exceeded.
Slovenian: V tem primeru se ne sme prekoračiti odmerka 2,5 mg na dan.
English: If a dose is missed, the patient should not take an additional dose, but take the next prescribed dose as usual.
Slovenian: Če bolnik pozabi vzeti odmerek, naj ne jemlje dodatnega odmerka, temveč naj vzame samo naslednji predpisani odmerek kot običajno.
English: Randomisation was stratified by documented sensitivity to prior hormonal therapy and by the presence of visceral metastasis.
Slovenian: Randomizacija je bila stratificirana glede na dokumentirano občutljivost na predhodno hormonsko zdravljenje in glede na prisotnost visceralnih metastaz.
English: Re-initiate treatment at same dose.
Slovenian: Ponovno začnite zdravljenje v enakem odmerku.
English: Frequency categories are defined using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000).
Slovenian: Kategorije pogostnosti so opredeljene po naslednjem dogovoru: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000).
English: Other medicines and Afinitor
Slovenian: Druga zdravila in zdravilo Afinitor
English: If you have liver problems, your doctor may start you on a lower dose of Afinitor (2.5, 5 or 7.5 mg per day).
Slovenian: Če imate težave z jetri, vam bo zdravnik morda predpisal nižji začetni odmerek zdravila Afinitor (2,5, 5 ali 7,5 mg na dan).
English: Due to between subject variability the recommended dose adjustments may not be optimal in all individuals, therefore close monitoring of side effects is recommended.
Slovenian: Zaradi razlik med posamezniki priporočeni odmerki morda ne bodo najbolj ustrezni pri vseh, zato je priporočeno skrbno spremljanje imatinib
English: Most of the side effects are mild to moderate and will generally disappear if your treatment is interrupted for a few days.
Slovenian: Večina neželenih učinkov je blago do zmerno izraženih in večinoma izzvenijo, če za nekaj dni prekinete zdravljenje.
English: Confirmed objective tumour responses were observed in 5 patients (2%) receiving Afinitor, while none were observed in patients receiving placebo.
Slovenian: Potrjen objektivni odziv tumorja so zabeležili pri 5 bolnikih (2 %), ki so jemali zdravilo Afinitor, medtem ko pri bolnikih, ki so jemali placebo, niso zabeležili nobenega.
English: • Pain in the mouth
Slovenian: • bolečine v ustih
English: if you have previously had hepatitis B, because this may be reactivated during treatment with Afinitor (see section 4 ‘Possible side effects').
Slovenian: če ste imeli kdaj prej hepatitis B, ker se med zdravljenjem z zdravilom Afinitor virus lahko reaktivira (glejte poglavje 4 “Možni neželeni učinki”).
English: Afinitor should be administered orally once daily at the same time every day, consistently either with or without food (see section 5.2).
Slovenian: Zdravilo Afinitor je treba vzeti peroralno enkrat na dan, vsak dan ob istem času, vedno s hrano ali vedno brez nje (glejte poglavje 5.2).
English: Light fat meals reduced AUC by 32% and Cmax by 42%.
Slovenian: Obroki z nizko vsebnostjo maščob so znižali AUC za 32 %, Cmax pa za 42 %.
English: If you have any questions about Afinitor or why it has been prescribed for you, ask your doctor.
Slovenian: Če imate vprašanja o zdravilu Afinitor ali vas zanima, zakaj so vam ga predpisali, se obrnite na svojega zdravnika.
English: In the safety pooling, 37% of the Afinitor-treated patients were ≥65 years of age.
Slovenian: Po združenih podatkih o varnosti zdravila je bilo 37 % bolnikov, ki so prejemali zdravilo Afinitor, starih ≥65 let.
English: If dose reduction is required, the recommended dose is 5 mg daily and must not be lower than 5 mg daily.
Slovenian: Če je treba odmerek znižati, je priporočeni odmerek 5 mg dnevno, ne sme pa biti nižji od 5 mg dnevno.
English: Therefore, the safety and efficacy of Afinitor in patients with functional carcinoid tumours have not been established.
Slovenian: Varnost in učinkovitost uporabe zdravila Afinitor pri bolnikih s funkcionalnimi karcinoidnimi tumorji torej nista bili potrjeni.
English: Based on analysis of population pharmacokinetics, CL/F is on average 20% higher in black transplant patients.
Slovenian: Na podlagi analize populacijske farmakokinetike je CL/F pri bolnikih črne rase po presaditvi povprečno za 20 % večji.
English: Reactivation of infection is an expected event during periods of immunosuppression.
Slovenian: Reaktivacija okužbe je v obdobju zaviranja imunskega odziva pričakovan pojav.
English: Patients should be advised to be cautious when driving or using machines if they experience fatigue during treatment with Afinitor.
Slovenian: Bolnike je treba opozoriti, naj bodo previdni pri vožnji in upravljanju s stroji, če pri njih v času zdravljenja z zdravilom Afinitor prihaja do utrujenosti.
English: Rare (may affect up to 1 in 1,000 people) • Shortness of breath or rapid breath (signs of acute respiratory distress syndrome)
Slovenian: Redki (lahko se pojavijo pri največ 1 od 1.000 bolnikov) • zadihanost ali hitro dihanje (znaki sindroma akutne dihalne stiske)
English: The immune response to vaccination may be affected and, therefore, vaccination may be less effective during treatment with Afinitor.
Slovenian: Zdravilo Afinitor lahko vpliva na imunski odziv na cepljenje, zato je lahko cepljenje med zdravljenjem z zdravilom Afinitor manj učinkovito.
English: This is because these can also be affected by Afinitor.
Slovenian: To je potrebno zato, ker zdravilo Afinitor lahko vpliva tudi nanje.
English: If you think you may be allergic, ask your doctor for advice.
Slovenian: Če mislite, da bi bili lahko alergični, se posvetujte z zdravnikom.
English: A clinically significant effect on the efficacy response to everolimus in patients with advanced neuroendocrine tumours could not be established.
Slovenian: Klinično pomembnega vpliva na učinkovitostni odziv na everolimus pri bolnikih z napredovalimi nevroendokrinimi tumorji ni bilo mogoče potrditi.
English: Afinitor may elevate cholesterol and/or other blood fats.
Slovenian: Zdravilo Afinitor lahko zviša raven holesterola in/ali drugih maščob v krvi.
English: Administration of everolimus for up to 2 years did not indicate any oncogenic potential in mice and rats up to the highest doses, corresponding respectively to 3.9 and 0.2 times the estimated clinical exposure.
Slovenian: Uporaba everolimusa v trajanju do 2 leti ni pokazala onkogenega potenciala pri miših in podganah do najvišjih odmerkov, ki so ustrezali 3,9-kratniku oziroma 0,2-kratniku ocenjene klinične izpostavljenosti.
English: Afinitor tablets should be swallowed whole with a glass of water.
Slovenian: Tablete Afinitor je treba pogoltniti cele, s kozarcem vode.
English: Table 5 RADIANT-3 - efficacy results
Slovenian: Preglednica 5 Študija RADIANT-3 - rezultati učinkovitosti
English: The recommended dose is 10 mg, taken once a day.
Slovenian: Priporočeni odmerek je 10 mg in ga vzamete enkrat na dan.
English: Very common Weight decreased * See also subsection “Description of selected adverse reactions”
Slovenian: Preiskave zelo pogosti znižana telesna masa * glejte podpoglavje “Opis izbranih neželenih učinkov”
English: Everolimus is a selective mTOR (mammalian target of rapamycin) inhibitor.
Slovenian: Everolimus je selektiven zaviralec mTOR (tarče rapamicina pri sesalcih, mammalian target of rapamycin).
English: Afinitor contains lactose (milk sugar).
Slovenian: Zdravilo Afinitor vsebuje laktozo (mlečni sladkor).
English: If symptoms are moderate (Grade 2) or severe (Grade 3) the use of corticosteroids may be indicated until clinical symptoms resolve.
Slovenian: Pri zmerno (stopnje 2) ali zelo izraženih simptomih (stopnje 3) je včasih indicirana uporaba kortikosteroidov, dokler klinični simptomi ne izzvenijo.
English: It is given together with a medicine called exemestane, a steroidal aromatase inhibitor, which is used for hormonal anticancer therapy.
Slovenian: Jemlje se skupaj z zdravilom, imenovanim eksemestan, steroidni zaviralec aromataze, ki se uporablja za hormonsko zdravljenje raka.
English: What you need to know before you take Afinitor
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Afinitor
English: Some mouthwashes and gels can make ulcers worse, so do not try anything without checking with your doctor first.
Slovenian: Uporaba nekaterih tekočin za izpiranje ust ali gelov lahko poslabša razjede, zato ne preizkušajte izdelkov, o katerih se niste prej posvetovali z vašim zdravnikom.
English: Supportive/sensitivity analyses All (local review by investigator)
Slovenian: Analiza dodatnega pregleda za oceno občutljivosti vsi (pregledovanje je lokalno opravil raziskovalec)
English: The preclinical safety profile of everolimus was assessed in mice, rats, minipigs, monkeys and rabbits.
Slovenian: Predklinične varnostne lastnosti everolimusa so ocenjevali pri miših, podganah, prašičkih, opicah in kuncih.
English: Functional carcinoid tumours
Slovenian: Funkcionalni karcinoidni tumorji
English: Renal function should be monitored particularly where patients have additional risk factors that may further impair renal function.
Slovenian: Treba je spremljati ledvično funkcijo, še zlasti kadar so prisotni tudi drugi dejavniki tveganja, ki lahko dodatno poslabšajo delovanje ledvic.
English: (20.9 to 32.4)
Slovenian: (20,9 do 32,4)
English: Therefore, the progression-free survival advantage primarily reflects the population with disease stabilisation (corresponding to 67% of the Afinitor treatment group).
Slovenian: Podaljšanje preživetja brez napredovanja bolezni gre torej predvsem na račun populacije s stabilizacijo bolezni (ki je predstavljala 67 % bolnikov v skupini z zdravilom Afinitor).
English: Physicians and patients should be aware of the increased risk of infection with Afinitor.
Slovenian: Zdravniki in bolniki se morajo zavedati, da zdravilo Afinitor povečuje tveganje za okužbe.
English: Afinitor may have a minor or moderate influence on the ability to drive and use machines.
Slovenian: Zdravilo Afinitor ima lahko blag do zmeren vpliv na sposobnost vožnje in upravljanja s stroji.
English: Do not take Afinitor if you are allergic to everolimus, to related substances such as sirolimus or temsirolimus, or to any of the other ingredients of this medicine (listed in section 6).
Slovenian: Ne jemljite zdravila Afinitor če ste alergični na everolimus, na spojine, ki so sorodne everolimusu, na primer na sirolimus ali temsirolimus, ali na katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: It is given if the tumours are inoperable and do not overproduce specific hormones or other related natural substances.
Slovenian: Bolniki prejmejo zdravilo Afinitor v primeru, da tumorja ni mogoče operirati in ne sprošča prekomernih količin specifičnih hormonov ali drugih podobnih naravnih snovi.
English: If you forget to take Afinitor
Slovenian: Če ste pozabili vzeti zdravilo Afinitor
English: No (N=225) Lung (N=90) Ileum (N=71) Non-ileum* (N=141) Grade 1 (N=194) Grade 2 (N=107) ≤10% (N=228) >10% (N=72) >2xULN (N=139) ≤2xULN (N=138) >ULN (N=87) ≤ULN (N=188)
Slovenian: ne (N=225) pljuča (N=90) ileum (N=71) izven ileuma* (N=141) gradus 1 (N=194) gradus 2 (N=107) ≤10 % (N=228) >10 % (N=72) >2xZMN (N=139) ≤2xZMN (N=138) >ZMN (N=87) ≤ZMN (N=188)
English: S6K1is thought to phosphorylate the activation function domain 1 of the oestrogen receptor, which is responsible for ligand-independent receptor activation.
Slovenian: S6K1 naj bi na estrogenskih receptorjih fosforilirala aktivacijsko domeno 1, ki je odgovorna za od liganda neodvisno aktivacijo receptorja.
English: If you experience any of these side effects, tell your doctor immediately as this might have life-threatening consequences.
Slovenian: Če pride do katerega od zgoraj navedenih neželenih učinkov, takoj obvestite zdravnika, saj so posledice lahko življenjsko nevarne.
English: No statistically significant treatment-related difference in overall survival was noted (hazard ratio 0.87; confidence interval: 0.65-1.17; p=0.177).
Slovenian: Statistično značilne z zdravljenjem povezane razlike v celotnem preživetju niso zabeležili (razmerje tveganj 0,87; interval zaupanja: 0,65-1,17; p=0,177).
English: Infections and infestations Very common Infections a, *
Slovenian: Infekcijske in parazitske bolezni zelo pogosti okužbe a,
English: Censoring Times
Slovenian: časi cenzuriranja
English: Telithromycin, clarithromycin Nefazodone Ritonavir, atazanavir, saquinavir, darunavir, indinavir, nelfinavir
Slovenian: telitromicin, klaritromicin nefazodon ritonavir, atazanavir, sakvinavir, darunavir, indinavir, nelfinavir
English: Censoring Times Everolimus (n/N = 155/277) Placebo (n/N = 111/139)
Slovenian: časi cenzuriranja everolimus (n/N = 155/277) placebo (n/N = 111/139)
English: These will check the amount of blood cells (white blood cells, red blood cells and platelets) in your body to see if Afinitor is having an unwanted effect on these cells.
Slovenian: Med zdravljenjem boste redno opravljali preiskave krvi za preverjanje števila krvnih celic (belih in rdečih krvnih celic ter trombocitov) v telesu, da bi lahko opazili, če bi imelo zdravilo Afinitor neželene učinke na te celice.
English: If you are taking any of them, your doctor may switch you to a different medicine, or may change your dose of Afinitor.
Slovenian: Če jemljete katero od njih, vam bo zdravnik morda zdravilo zamenjal za drugo ali pa vam bo spremenil odmerek zdravila Afinitor.
English: The number of patients with an adverse reaction leading to discontinuation of the medicinal product was higher in patients ≥65 years of age (20% vs. 13%).
Slovenian: Število bolnikov, pri katerih je bilo zaradi neželenega učinka treba prekiniti uporabo zdravila, je bilo večje med bolniki, ki so bili stari ≥65 let (20 % v primerjavi s 13 %).
English: • Bleeding (haemorrhage), for example in the gut wall
Slovenian: • krvavitev, na primer v črevesni steni
English: Blood tests will also be carried out to check your kidney function (level of creatinine) and liver function (level of transaminases) and your blood sugar and cholesterol levels.
Slovenian: Krvne preiskave boste opravljali tudi za preverjanje delovanja ledvic (raven kreatinina), delovanja jeter (ravni aminotransferaz) in ravni sladkorja ter holesterola v krvi.
English: More frequent monitoring is recommended when Afinitor is co-administered with other medicinal products that may induce hyperglycaemia.
Slovenian: Pogostejše spremljanje je priporočeno v primeru sočasne uporabe zdravila Afinitor z drugimi zdravili, ki lahko sprožijo hiperglikemijo.
English: The overall safety profile in this study was consistent with that established for everolimus in the oncology and tuberous sclerosis complex (TSC) settings, with the exception of a slightly increased frequency of oral candidiasis which was reported in 2.2% (n=2/92) of patients.
Slovenian: Celotni varnostni profil v tej študiji se je ujemal z varnostnim profilom everolimusa v okviru zdravljenja onkoloških bolezni in tuberozne skleroze (TSC- tuberous sclerosis complex), razen nekoliko povečane pogostnosti oralne kandidoze, o kateri so poročali pri 2,2 % (n=2/92) bolnic.
English: Carbamazepine, phenobarbital, phenytoin
Slovenian: karbamazepin, fenobarbital, fenitoin
English: Sensitivity to prior hormonal therapy was defined as either (1) documented clinical benefit (complete response [CR], partial response [PR], stable disease ≥24 weeks) from at least one prior hormonal therapy in the advanced setting or (2) at least 24 months of adjuvant hormonal therapy prior to recurrence.
Slovenian: Občutljivost na predhodno hormonsko zdravljenje je bila opredeljena bodisi kot (1) dokumentirana klinična korist (popoln odziv, delen odziv, stabilna bolezen ≥24 tednov) najmanj enega predhodno uporabljenega hormonskega zdravila pri zdravljenju napredovalega raka ali kot (2) najmanj 24 mesecev dopolnilnega hormonskega zdravljenja pred ponovitvijo bolezni.
English: If a diagnosis of invasive systemic fungal infection is made, the Afinitor treatment should be promptly and permanently discontinued and the patient treated with appropriate antifungal therapy.
Slovenian: Če se pri bolniku ugotovi invazivno sistemsko glivično okužbo, je treba zdravljenje z zdravilom Afinitor takoj in dokončno ukiniti, bolnika pa zdraviti z ustreznimi protiglivičnimi zdravili.
English: If you experience certain side effects while you are taking Afinitor (see section 4), your doctor may lower your dose or stop treatment, either for a short time or permanently.
Slovenian: Če pride do določenih neželenih učinkov v času jemanja zdravila Afinitor (glejte poglavje 4), vam bo zdravnik morda znižal odmerek ali prekinil zdravljenje z zdravilom Afinitor, bodisi za krajši čas ali pa dokončno.
English: Patients who develop radiological changes suggestive of non-infectious pneumonitis and have few or no symptoms may continue Afinitor therapy without dose adjustments.
Slovenian: Bolniki, pri katerih pride do radioloških sprememb, ki bi lahko bile neinfekcijska pljučnica, vendar imajo le malo simptomov ali jih sploh nimajo, lahko nadaljujejo z jemanjem zdravila Afinitor brez spremembe odmerka.
English: Grade 4 Discontinue treatment.
Slovenian: Stopnja 4 Prenehajte z zdravljenjem.
English: Your doctor might need to interrupt or discontinue your treatment with Afinitor.
Slovenian: Zdravnik bo morda moral začasno ali trajno prekiniti vaše zdravljenje z zdravilom Afinitor.
English: Pre-existing infections should be treated appropriately and should have resolved fully before starting treatment with Afinitor.
Slovenian: Že prisotne okužbe je treba ustrezno zdraviti in jih v celoti odpraviti pred začetkom zdravljenja z zdravilom Afinitor.
English: • Menstruation disorders such as absence of periods (amenorrhoea)
Slovenian: • motnje menstrualnega ciklusa, kot je izostanek menstruacije (amenoreja)
English: Other possible side effects of Afinitor include:
Slovenian: Drugi možni neželeni učinki zdravila Afinitor so:
English: Afinitor may increase the risk of problems with wound healing.
Slovenian: Zdravilo Afinitor lahko poveča tveganje za težave pri celjenju rane.
English: Management of severe and/or intolerable suspected adverse reactions may require dose reduction and/or temporary interruption of Afinitor therapy.
Slovenian: Med ukrepi pri hudih ali nesprejemljivih neželenih učinkih je lahko tudi znižanje odmerka in/ali začasna prekinitev zdravljenja z zdravilom Afinitor.
English: Kaplan-Meier medians Everolimus: 4.90 months Placebo: 1.87 months
Slovenian: Kaplan-Meierjeve mediane everolimus: 4,90 meseca placebo: 1,87 meseca
English: If you are taking other medicines at the same time as Afinitor, your doctor may need to change the dose of Afinitor or the other medicines.
Slovenian: Če jemljete druga zdravila sočasno z zdravilom Afinitor, vam bo moral zdravnik morda spremeniti odmerke zdravila Afinitor ali drugih zdravil.
English: Neuroendocrine tumours of pancreatic origin
Slovenian: Nevroendokrini tumorji pankreatičnega izvora
English: Single doses of up to 70 mg have been given with acceptable acute tolerability.
Slovenian: Posamezne odmerke do 70 mg so bolniki prenašali z akutnimi simptomi, ki so bili sprejemljivi.
English: Following disease progression or after study unblinding, 172 of the 203 patients (84.7%) initially randomised to placebo crossed over to open-label Afinitor.
Slovenian: Po napredovanju bolezni ali po razkritju, katero slepo zdravljenje je bolnik prejemal, je 172 od 203 bolnikov (84,7 %), ki so bili sprva randomizirani na uporabo placeba, prešlo na odprto uporabo zdravila Afinitor.
English: • Swelling of arms, hands, feet, ankles or other part of the body (signs of oedema)
Slovenian: • otekanje rok, dlani, stopal, gležnjev ali drugih delov telesa (znaki edema)
English: Adverse reactions are listed according to MedDRA system organ class and frequency category.
Slovenian: Neželeni učinki so našteti v skladu s skupinami organskih sistemov po klasifikaciji MedDRA in po kategorijah pogostnosti.
English: Table 4 BOLERO-2 efficacy results
Slovenian: Preglednica 4 Rezultati učinkovitosti v študiji BOLERO-2
English: 30 tablets 90 tablets
Slovenian: 30 tablet 90 tablet
English: Everolimus has immunosuppressive properties and may predispose patients to bacterial, fungal, viral or protozoan infections, including infections with opportunistic pathogens (see section 4.8).
Slovenian: Everolimus ima imunosupresivne lastnosti in lahko pri bolnikih poveča nagnjenost k okužbam, ki jih povzročajo bakterije, glivice, virusi ali protozoji, vključno z okužbami z oportunističnimi patogeni (glejte poglavje 4.8).
English: Everolimus is a potent inhibitor of the growth and proliferation of tumour cells, endothelial cells, fibroblasts and blood-vessel-associated smooth muscle cells and has been shown to reduce glycolysis in solid tumours in vitro and in vivo.
Slovenian: Everolimus je močan zaviralec rasti in proliferacije tumorskih celic, endotelijskih celic, fibroblastov in s krvnimi žilami povezanih gladkih mišičnih celic, pokazalo pa se je, da zmanjšuje tudi obseg glikolize v trdih tumorjih in vitro in in vivo.
English: Table 1 summarises the dose adjustment recommendations for specific adverse reactions (see also section 4.4).
Slovenian: Preglednica 1 povzema priporočila za prilagajanje odmerka pri posameznih neželenih učinkih (glejte tudi poglavje 4.4).
English: Afinitor will only be prescribed for you by a doctor with experience in cancer treatment.
Slovenian: Zdravilo Afinitor vam lahko predpiše samo zdravnik, ki ima izkušnje z zdravljenjem bolnikov z rakom.
English: Independent radiological review
Slovenian: ocena radiološkega izvida s strani neodvisnega pregledovalca
English: Inhibition of the mTORC1 signalling pathway interferes with the translation and synthesis of proteins by reducing the activity of S6 ribosomal protein kinase (S6K1) and eukaryotic elongation factor 4E-binding protein (4EBP-1) that regulate proteins involved in the cell cycle, angiogenesis and glycolysis.
Slovenian: Zaviranje prenosa signala z mTORC1 ovira proces translacije in sintezo proteinov, tako da zmanjšuje delovanje S6 ribosomske protein-kinaze (S6K1) in vezavnega proteina za evkariontski dejavnik podaljševanja 4E (eukaryotic elongation factor 4E-binding protein, 4EBP-1), ki uravnavata proteine, vpletene v celični ciklus, angiogenezo in glikolizo.
English: Afinitor may have an impact on female fertility.
Slovenian: Zdravilo Afinitor lahko vpliva na plodnost pri ženskah.
English: For patients who require use of corticosteroids for treatment of non-infectious pneumonitis, prophylaxis for PJP/PCP may be considered.
Slovenian: Pri bolnikih, pri katerih je za zdravljenje neinfekcijske pljučnice potrebna uporaba kortikosteroidov, je smiselno razmisliti o profilaksi PJP/PCP.
English: After documented radiological progression, patients could be unblinded by the investigator: those randomised to placebo were then able to receive open-label everolimus 10 mg/day.
Slovenian: Po radiološko potrjenem napredovanju bolezni je lahko zdravnik razkril, katero slepo zdravljenje je bolnik prejemal: bolniki, ki so do tedaj prejemali placebo, so lahko začeli prejemati odprto zdravljenje z everolimusom 10 mg/dan.
English: Kaplan-Meier medians Everolimus/Exemestane: 36.57 [28.71;42.29] weeks Everolimus: 29.43 [24.00;31.29] weeks
Slovenian: Kaplan-Meierjeve mediane everolimus/eksemestan: 36,57 [28,71;42,29] tedna everolimus: 29,43 [24,00;31,29] tedna čas (tedni)
English: • swelling of the face, lips, tongue or throat
Slovenian: • otekanje obraza, ustnic, jezika ali grla oziroma žrela,
English: Management of stomatitis may therefore include prophylactic and/or therapeutic use of topical treatments, such as an alcohol-free corticosteroid oral solution as a mouthwash.
Slovenian: Obvladovanje stomatitisa lahko zato vključuje profilaktično in terapevtsko uporabo zdravil za lokalno uporabo, kot je kortikosteroidna oralna raztopina brez alkohola v obliki raztopine za izpiranje ust.