FrancophonIA/ELRC3.0 huggingface dataset:
English: Following oral administration, naloxone is barely detectable in plasma; following sublingual administration of buprenorphine/naloxone, plasma naloxone concentrations are low and decline rapidly.
Slovenian: Po peroralni administraciji se nalokson komaj zazna v plazmi; po uporabi buprenorfina/naloksona pod jezikom so koncentracije naloksona nizke in se hitro zmanjšujejo.
English: Patients should be monitored for signs and symptoms of precipitated opioid withdrawal, toxicity or overdose caused by increased levels of naloxone and/or buprenorphine.
Slovenian: Bolnike je treba spremljati glede znakov in simptomov odtegnitvenega sindroma, toksičnosti ali prekomernega odmerjanja zaradi povečane ravni naloksona in/ali buprenorfina.
English: What do you need to know before you take Suboxone
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Suboxone
English: Combining buprenorphine with naloxone in Suboxone is intended to deter misuse and abuse of the buprenorphine.
Slovenian: Kombiniranje buprenorfina z naloksonom v zdravilu Suboxone je namenjeno preprečevanju napačne uporabe in zlorabe buprenorfina.
English: These types of medicines will reduce you alertness levels making it difficult for you to drive and use machines.
Slovenian: Te vrste zdravil zmanjšajo pozornost, zato vas motijo pri vožnji in upravljanju strojev.
English: Treatment must be under the supervision of a physician experienced in the management of opiate dependence/addiction.
Slovenian: Zdravljenje mora potekati pod nadzorom zdravnika, ki ima izkušnje z vodenjem odvisnosti od opiatov oz. z zasvojenostjo z opiati.
English: o other central nervous system depressants, other opioid derivatives (e.g. methadone, analgesics and antitussives), certain antidepressants, sedative H1-receptor antagonists, barbiturates, anxiolytics other than benzodiazepines, neuroleptics, clonidine and related substances: these combinations increase central nervous system depression.
Slovenian: o Drugimi depresivi osrednjega živčnega sistema, drugimi opioidnimi derivativi (npr. metadon, analgetiki in antitusiki), nekaterimi antidepresivi, sedativnimi agonisti receptorja H1, barbiturati, anksiolitiki, ki niso benzodiazepini, nevroleptiki, klonidin in z njim povezanimi snovmi, saj te kombinacije povečajo depresijo osrednjega živčnega sistema.
English: • Starting treatment of Suboxone whilst dependent on methadone
Slovenian: • Začetek zdravljenja z zdravilom Suboxone med odvisnostjo od metadona
English: The spectrum of abnormalities ranges from transient asymptomatic elevations in hepatic transaminases to case reports of hepatic failure, hepatic necrosis, hepatorenal syndrome, hepatic encephalopathy and death.
Slovenian: Spekter abnormalnih izvidov se giblje od prehodnega asimptomatskega zvišanja jetrnih transaminaz do poročil o primerih odpovedi jeter, jetrne nekroze, hepatorenalnega sindroma, hepatične encefalopatije in smrti.
English: The availability of doses of 2 mg/0.5 mg and 8 mg/2 mg allows for a downward titration of dosage.
Slovenian: Razpoložljivost odmerkov 2 mg/0,5 mg in 8 mg/2 mg omogoča prilagajanje odmerka z manjšanjem količine zdravila.
English: 2 - Remove just one section from the blister pack, tearing it along the perforated line.
Slovenian: 2 - S pretisnega omota odstranite le eno enoto tako, da jo odtrgate po perforirani črti.
English: Do not drive, use any tools or machines, or perform dangerous activities until you know how this medicine affects you.
Slovenian: Dokler ne veste, kako zdravilo vpliva na vas, ne vozite, ne uporabljajte orodij ali strojev in ne izvajajte nevarne dejavnosti.
English: Buprenorphine/naloxone has minor to moderate influence on the ability to drive and use machines when administered to opioid dependent patients.
Slovenian: Buprenorfin/nalokson ima blag do zmerno močan vpliv na sposobnost vožnje in upravljanja s stroji, če se ga daje bolnikom, ki so odvisni od opiatov.
English: The dose can be made up from multiple Suboxone tablets of different strengths, which may be taken all at the same time or in two divided portions; the second portion to be taken directly after the first portion has dissolved.
Slovenian: Odmerek je lahko sestavljen iz več tablet zdravila Suboxone različnih jakosti, ki jih je možno vzeti naenkrat ali v dveh delih; drugi del je treba vzeti neposredno za tem, ko se prvi del raztopi.
English: Dosage adjustment and maintenance therapy:
Slovenian: Prilagajanje odmerka in vzdrževalno zdravljenje:
English: Long-term administration of buprenorphine during the last three months of pregnancy may cause a withdrawal syndrome in the neonate (e.g. hypertonia, neonatal tremor, neonatal agitation, myoclonus or convulsions).
Slovenian: Dolgotrajnejša uporaba buprenorfina v zadnjem tromesečju nosečnosti lahko povzroči odtegnitveni sindrom pri novorojenčku (npr. hipertonija, neonatalni tremor, neonatalna agitacija, mioklonus ali konvulzije).
English: Buprenorphine/naloxone may cause drowsiness, particularly when taken together with alcohol or central nervous system depressants (such as tranquilisers, sedatives or hypnotics) (see section 4.5).
Slovenian: Buprenorfin/nalokson lahko povzroča zaspanost, še zlasti pri jemanju skupaj z alkoholom ali depresivi osrednjega živčnega sistema (kot so pomirjevala in uspavala) (glejte poglavje 4.5).
English: If you stop taking Suboxone
Slovenian: Če ste prenehali jemati zdravilo Suboxone
English: Buprenorphine and its metabolites are excreted in human breast milk.
Slovenian: Buprenorfin in njegovi presnovki se izločajo v materino mleko.
English: Abrupt discontinuation of treatment is not recommended as it may result in a withdrawal syndrome that may be delayed in onset.
Slovenian: Nenadna prekinitev zdravljenja ni priporočljiva, ker lahko povzroči odtegnitveni sindrom, ki se lahko pojavi z zamikom.
English: When initiating treatment with buprenorphine/naloxone, the physician must be aware of the partial agonist profile of buprenorphine and that it can precipitate withdrawal in opioid-dependent patients, particularly if administered less than 6 hours after the last use of heroin or other short-acting opioid, or if administered less than 24 hours after the last dose of methadone.
Slovenian: Ob začetku zdravljenja z buprenorfinom/naloksonom mora zdravnik poznati profil delnega agonista buprenorfina in se zavedati dejstva, da lahko povzroči odtegnitveni sindrom pri bolnikih, odvisnih od opioidov, še posebej če se ga da manj kot 6 ur po zadnji uporabi heroina ali kratkotrajno delujočega opioida, ali če se ga da manj kot 24 ur po zadnjemu odmerku metadona.
English: The dose is made up from multiple Suboxone tablets of different strengths, which may be taken all at the same time or in two divided portions; the second portion to be taken directly after the first portion has dissolved.
Slovenian: Odmerek je sestavljen iz več tablet zdravila Suboxone različnih jakosti, ki jih je možno vzeti naenkrat ali v dveh delih; drugi del je treba vzeti neposredno za tem, ko se prvi del raztopi.
English: Therefore the potential to overdose with a full agonist exists, especially when attempting to overcome buprenorphine partial agonist effects, or when buprenorphine plasma levels are declining.
Slovenian: Posledično obstaja možnost prevelikega odmerjanja polnih agonistov, še zlasti če želimo premagati delne agonistične učinke buprenorfina ali kadar se plazemske koncentracije buprenorfina zmanjšujejo.
English: o For patients receiving methadone, the dose of methadone should be reduced to a maximum of 30 mg/day before beginning buprenorphine/naloxone therapy.
Slovenian: o Pri bolnikih, ki prejemajo metadon, je treba odmerek metadona zmanjšati na največ 30 mg/dan pred začetkom zdravljenja z buprenorfinom/naloksonom.
English: No dose modification based on renal function is required but caution is recommended when dosing subjects with severe renal impairment (see Section 4.3).
Slovenian: Odmerka na osnovi ledvične funkcije ni potrebno spreminjati, priporoča pa se pozornost pri odmerjanju pri osebah s hudo okvaro ledvic (glejte poglavje 4.3).
English: Insomnia (inability to sleep), constipation, nausea, excessive sweating, headache, drug withdrawal syndrome
Slovenian: Nespečnost (nezmožnost spanja), zaprtost, slabost, prekomerno potenje, glavobol, sindrom odtegnitve mamil
English: What Suboxone is and what it is used for What do you need to know before you take Suboxone How to take Suboxone
Slovenian: Kaj je zdravilo Suboxone in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Suboxone Kako jemati zdravilo Suboxone Možni neželeni učinki
English: The medicinal product is metabolized in the liver, primarily by glucuronide conjugation, and excreted in the urine.
Slovenian: Zdravilo se presnavlja v jetrih, za kar je v glavnem odgovoren proces glukuronidne konjugacije in se izloča v urinu.
English: The lowest dose studied represented exposure multiples of 1x for buprenorphine and 5x for naloxone at the maximum human therapeutic dose calculated on a mg/m² basis.
Slovenian: Najnižji odmerek v študiji je predstavljal večkratnik izpostavitve 1x za buprenorfin in 5x za nalokson pri največjem terapevtskem odmerku za ljudi, ki je bil izračunan v mg/m².
English: East Yorkshire HU8 7DS,
Slovenian: Hull, East Yorkshire HU8 7DS
English: • Keep the tablets in place under the tongue until they have completely dissolved.
Slovenian: • Tablete morate imeti pod jezikom, dokler se popolnoma ne raztopijo.
English: Statistically significant increases in the incidence of benign testicular interstitial (Leydig's) cell adenomas were observed in all dosage groups.
Slovenian: V vseh skupinah odmerjanja opazili so statistično pomembna povečanja pojavnosti benignega testikularnega adenoma intersticijskih celic (Leydigove celice).
English: Naloxone can be cleared more rapidly than buprenorphine, allowing for a return of previously controlled buprenorphine overdose symptoms, so a continuing infusion may be necessary.
Slovenian: Nalokson se izloči hitreje kot buprenorfin, zato se lahko znova pojavijo že nadzorovani simptomi prevelikega odmerjanja buprenorfina, zaradi česar bo morda potrebna dolgotrajna infuzija.
English: Opioids may elevate cerebrospinal fluid pressure, which may cause seizures, so opioids should be used with caution in patients with head injury, intracranial lesions, other circumstances where cerebrospinal pressure may be increased, or history of seizure.
Slovenian: Opioidi lahko povečajo tlak cerebrospinalne tekočine, kar lahko povzroči epileptične napade, zato jih je treba uporabljati previdno pri bolnikih s poškodbami glave, intrakranialnimi lezijami, drugimi stanji, ki lahko privedejo do povečanja tlaka cerebrospinalne tekočine, ali pri bolnikih z anamnezo epileptičnih napadov.
English: If naloxone is used, the long duration of action of buprenorphine should be taken into consideration when determining the length of treatment and medical surveillance needed to reverse the effects of an overdose.
Slovenian: Ob uporabi naloksona je treba pri določanju trajanja zdravljenja in zdravniškega nadzorovanja, ki je potrebno za preprečitev učinka prevelikega odmerjanja, upoštevati dolgotrajnost delovanja buprenorfina.
English: The most commonly reported treatment related adverse reactions reported during the pivotal clinical trials were constipation and symptoms commonly associated with drug withdrawal (i.e. insomnia, headache, nausea, hyperhidrosis and pain).
Slovenian: Z zdravljenjem najpogosteje povezani neželeni učinki, o katerih so poročali med glavnimi kliničnimi raziskavami, so bili zaprtost in simptomi, ki so običajno povezani z odtegnitvijo zdravil (npr. nespečnost, glavobol, navzea, hiperhidroza in bolečina).
English: • if you have serious liver problems
Slovenian: • če imate hude težave z jetri
English: If you forget to take Suboxone Tell your doctor as soon as possible if you miss a dose.
Slovenian: Če ste pozabili vzeti zdravilo Suboxone Če pozabite vzeti odmerek, se čim prej posvetujte s svojim zdravnikom.
English: For example, a patient stabilised to receive a daily dose of 8 mg buprenorphine may be given 16 mg buprenorphine on alternate days, with no dose on the intervening days.
Slovenian: Tako lahko bolnik, ki je stabiliziran za prejemanje dnevnega odmerka v količini 8 mg buprenorfina, prejme 16 mg buprenorfina vsak drug dan, pri tem pa vmesne dni ne sme prejeti odmerka.
English: Intravenous or intranasal misuse of Suboxone is expected to be less likely than buprenorphine alone since the naloxone in Suboxone can precipitate withdrawal in individuals dependent on heroin, methadone, or other opioid agonists.
Slovenian: Intravenska ali intranazalna napačna uporaba zdravila Suboxone je manj verjetna kot napačna uporaba samo buprenorfina, ker lahko nalokson v zdravilu Suboxone sproži odtegnitev učinka pri bolnikih, ki so odvisni od heroina, metadona ali drugih opioidnih sredstev.
English: Regular blood tests may be conducted by your doctor to monitor the condition of your liver.
Slovenian: Vaš zdravnik se lahko odloči, da bo stanje vaših jeter spremljal z rednimi krvnimi testi.
English: • feeling sleepy and uncoordinated, have blurred vision, have slurred speech, cannot think well or clearly, or your breathing gets much slower than is normal for you.
Slovenian: • Občutek zaspanosti in nekoordiniranosti, zamegljen vid, nerazločen govor, nezmožnost treznega ali zbranega razmišljanja ali dihanje, ki postane veliko počasnejše, kot je sicer za vas običajno.
English: • Other medicines that may make you feel sleepy which are used to treat illnesses such as anxiety, sleeplessness, convulsions/seizures, pain.
Slovenian: • Druga zdravila, po katerih se počutite zaspani in se uporabljajo za zdravljenje tesnobe, nespečnosti, epileptičnih krčev/napadov, bolečin.
English: • if you have serious breathing problems
Slovenian: • če imate hude težave z dihanjem,
English: 5 How to store Suboxone Content of the pack and other information
Slovenian: 5 Shranjevanje zdravila Suboxone Vsebina pakiranja in dodatne informacije
English: Cases of acute hepatic injury have been reported in opioid-dependent addicts both in clinical trials and in post marketing adverse reaction reports.
Slovenian: Pri zasvojencih z opioidi so poročali o primerih akutnih poškodb jeter tako v kliničnih preskušanjih kot v poročilih o neželenih učinkih v obdobju trženja zdravila.
English: • if you are taking naltrexone or nalmefene for the treatment of alcohol or opioid dependence.
Slovenian: • če jemljete naltrekson ali nalmefen za zdravljenje odvisnosti od alkohola ali opioidov.
English: Keep out of the sight and reach of children and other household members.
Slovenian: Zdravilo shranjujte nedosegljivo otrokom in drugim članom gospodinjstva.
English: Suboxone is used to treat dependence on opioid (narcotic) drugs such as heroin or morphine in drug addicts who have agreed to be treated for their addiction.
Slovenian: Zdravilo Suboxone se uporablja za zdravljenje odvisnikov od mamil, ki so privolili v zdravljenje svoje odvisnosti od opioidnih (narkotičnih) mamil, kot sta heroin ali morfij.
English: Marketing Authorisation Holder Indivior Europe Limited 27 Windsor Place Dublin 2
Slovenian: Imetnik dovoljenja za promet Indivior Europe Limited 27 Windsor Place Dublin 2
English: Other medicines and Suboxone Tell your doctor if you are taking, have recently taken or might take any other medicines.
Slovenian: Obvestite zdravnika, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo
English: Do not take any other medicines whilst taking Suboxone without first talking to your doctor, especially:
Slovenian: Med zdravljenjem z zdravilom Suboxone ne uporabljajte nobenega drugega zdravila, ne da bi se prej posvetovali s svojim zdravnikom; to še posebej velja za naslednja zdravila:
English: Sub-optimal treatment with buprenorphine/naloxone may prompt medicine misuse by the patient, leading to overdose or treatment dropout.
Slovenian: Neoptimalno zdravljenje z buprenorfinom/naloksonom lahko spodbudi napačno uporabo zdravila pri bolniku, kar pomeni preveliko odmerjanje ali izstop iz zdravljenja.
English: o CYP3A4 inducers: Concomitant use of CYP3A4 inducers with buprenorphine may decrease buprenorphine plasma concentrations, potentially resulting in sub-optimal treatment of opioid dependence with buprenorphine.
Slovenian: o Induktorji CYP3A4: sočasna uporaba induktorjev CYP3A4 in buprenorfina lahko zmanjša plazemsko koncentracijo buprenorfina, zaradi česar lahko pride do neoptimalnega zdravljenja odvisnosti od opioidov z buprenorfinom.
English: However, when administered intravenously to opioid-dependent persons, the presence of naloxone in Suboxone produces marked opioid antagonist effects and opioid withdrawal, thereby deterring intravenous abuse.
Slovenian: Vendar pa prisotnost naloksona v zdravilu Suboxone pri intravenskemu dajanju osebam, ki so odvisne od opioidov, povzroči znatne antagonistične učinke na opioidnih receptorjih in opioidno odtegnitev, ter tako odvrača od intravenske uporabe.
English: Dietary administration of buprenorphine in the rat at dose levels of 500 ppm or greater produced a reduction in fertility demonstrated by reduced female conception rates.
Slovenian: Prehransko dajanje buprenorfina pri podganah v odmerku 500 ppm ali več je povzročilo zmanjšanje plodnosti, ki je bilo dokazano z zmanjšano pogostnostjo zanositve pri samicah.
English: During the initiation of treatment, daily supervision of dosing is recommended to ensure proper sublingual placement of the dose and to observe patient response to treatment as a guide to effective dose titration according to clinical effect.
Slovenian: Med začetkom zdravljenja se priporoča vsakodnevno nadzorovanje odmerjanja, da se zagotovi pravilna namestitev odmerka pod jezik in se opazuje odziv bolnika na zdravljenje, kar pripomore k učinkovitemu prilagajanju odmerka kliničnemu učinku.
English: Table 3 summarizes the results from a clinical trial in which the exposure after single-dose administration of Suboxone 2.0/0.5mg (buprenorphine/naloxone) sublingual tablet was determined in healthy subjects, and in subjects with hepatic impairment.
Slovenian: Preglednica 3 povzema rezultate iz klinične raziskave, v kateri je bila določena izpostavljenost zdravilu Suboxone 2,0/0,5 mg (buprenorfin/nalokson) podjezične tablete po enkratnem odmerjanju pri zdravih osebah in pri bolnikih z okvaro jeter.
English: In this trial, 326 heroin-addicted subjects were randomly assigned to either buprenorphine/naloxone 16 mg per day, 16 mg buprenorphine per day or placebo.
Slovenian: V tem preskusu so 326 odvisnikov od heroina naključno razporedili v skupino, ki je prejemala 16 mg buprenorfina/naloksona na dan, skupino, ki je prejemala 16 mg buprenorfina na dan, ali skupino, ki je prejemala placebo.
English: • if you are intoxicated due to alcohol or have trembling, sweating, anxiety, confusion, or hallucinations caused by alcohol
Slovenian: • če ste omamljeni z alkoholom ali se tresete, potite, ste tesnobni, zmedeni ali imate halucinacije,
English: When administered orally or sublingually in usual doses to patients experiencing opioid withdrawal, naloxone exhibits little or no pharmacological effect because of its almost complete first pass metabolism.
Slovenian: Ko se ga v običajnih odmerkih peroralno ali podjezično daje bolnikom z opioidno odtegnitvijo, pokaže nalokson majhen farmakološki učinek ali pa tega učinka celo ni, ker se skoraj popolnoma presnovi že pri prvem prehodu.
English: This could also be due to viral infections (chronic hepatitis C), alcohol abuse, anorexia or use of other medicines with the ability to harm your liver (see section 4).
Slovenian: To je lahko tudi posledica virusnih okužb (kronični hepatitis C), zlorabe alkohola, anoreksije ali jemanja drugih zdravil, ki lahko škodujejo jetrom (glejte poglavje 4).
English: Buprenorphine/naloxone is contraindicated in patients with severe hepatic impairment (see section 4.3 and 5.2).
Slovenian: Buprenorfin/nalokson je kontraindiciran pri bolnikih s hudo okvaro jeter (glejte poglavji 4.3 in 5.2).
English: In patients with severe hepatic insufficiency the use of buprenorphine/naloxone is contraindicated.
Slovenian: Pri bolnikih s hudo okvarjenim delovanjem jeter je uporaba buprenorfina/naloksona kontraindicirana.
English: Opioids should be used with caution in patients with myxoedema, hypothyroidism, or adrenal cortical insufficiency (e.g., Addison's disease).
Slovenian: Pri uporabi opioidov pri bolnikih z miksedemom, hipotiroidizmom ali adrenokortikalno insuficienco (na primer Addisonova bolezen) je potrebna previdnost.
English: If the patient vomits, care must be taken to prevent aspiration of the vomitus.
Slovenian: Če bolnik bruha, je treba paziti, da izbljuvka ne vdiha.
English: To avoid precipitating withdrawal, induction with buprenorphine/naloxone or buprenorphine only should be undertaken when objective and clear signs of withdrawal are evident (demonstrated e.g. by a score indicating mild to moderate withdrawal on the validated Clinical Opioid Withdrawal Scale, COWS).
Slovenian: Da ne bi sprožili odtegnitvenih simptomov, smete uvesti zdravljenje z buprenorfinom/naloksonom ali samo z buprenorfinom šele, ko se pojavijo objektivni in jasni znaki odtegnitve (kot na primer število točk, ki nakazuje blago do zmerno odtegnitev na uradni klinični lestvici odtegnitve od opioidov (COWSClinical Opioid Withdrawal Scale)).
English: A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALCI, ODGOVORNI ZA SPROŠČANJE SERIJE
English: If you are dependent upon heroin or a short acting opioid, your first dose of Suboxone should be taken when signs of withdrawal appear, but not less than 6 hours after you last used opioids.
Slovenian: Če ste odvisni od heroina ali kratkotrajno delujočega opioida, morate prvi odmerek zdravila Suboxone vzeti, ko se pojavijo znaki odtegnitve, vendar ne manj kot 6 ur po tem, ko ste vzeli zadnji opioid.
English: • anti-retrovirals (used to treat HIV) such as ritonavir, nelfinavir, indinavir may increase the effects of this medicine.
Slovenian: • Protiretrovirusna zdravila (za zdravljenje HIV-a), kot so ritonavir, nelfinavir in indinavir, lahko okrepijo učinke tega zdravila,
English: Table 1: Treatment-related adverse reactions reported in clinical trials and post-marketing surveillance of buprenorphine/naloxone
Slovenian: Preglednica 1: Z zdravljenjem povezani neželeni učinki, o katerih so poročali v kliničnih raziskavah in po prihodu buprenorfina/naloksona na trg
English: In cases of intravenous drug misuse, some adverse experiences are attributed to the act of misuse rather than the medicinal product and include local reactions, sometimes septic (abscess, cellulitis), and potentially serious acute hepatitis and other acute infections such as pneumonia, endocarditis have been reported (see section 4.4).
Slovenian: V primerih namerne intravenske napačne uporabe zdravil so nekatere neželene dogodke bolj pripisali napačni uporabi zdravila kot samemu zdravilu in poročali o lokalnih reakcijah, ki so včasih septične (absces, celulitis), in potencialno resnem akutnem hepatitisu in drugih akutnih okužbah, na primer pljučnica in endokarditis (glejte poglavje 4.4).
English: What Suboxone looks like and contents of the pack
Slovenian: Izgled zdravila Suboxone in vsebina pakiranja
English: To avoid precipitating withdrawal, induction with buprenorphine/naloxone should be undertaken when objective signs of withdrawal are evident (see section 4.2).
Slovenian: Za preprečitev odtegnitvenega sindroma morate uvajanje zdravljenja z buprenorfinom/naloksonom izvajati, ko so opazni objektivni znaki odtegnitve (glejte poglavje 4.2).
English: Suboxone sublingual tablets should be used with caution in patients with moderate hepatic impairment (See section 4.3 and 5.2).
Slovenian: Zdravilo Suboxone podjezične tablete je treba uporabljati previdno pri bolnikih z zmerno okvaro jeter (glejte poglavji 4.3 in 5.2).
English: Magnesium stearate Acesulfame potassium Natural lemon and lime flavour
Slovenian: Magnezijev stearat Kalijev acesulfam Naravna aroma limone in limete
English: Side effects reported with Suboxone
Slovenian: Neželeni učinki, o katerih so poročali pri zdravilu Suboxone