FrancophonIA/ELRC3.0 huggingface dataset:
English: However, it is unknown whether carfilzomib is an inducer of CYP1A2, 2C8, 2C9, 2C19 and 2B6 at therapeutic concentrations.
Slovenian: Ni pa znano, ali karfilzomib v terapevtski koncentraciji inducira CYP1A2, 2C8, 2C9, 2C19 in 2B6.
English: • Changes to blood tests (decreased blood levels of sodium, magnesium, protein, calcium or phosphate, increased blood levels of calcium, uric acid, potassium, bilirubin or c-reactive protein)
Slovenian: • spremembe preiskav krvi (znižanje koncentracij natrija, magnezija, beljakovin, kalcija ali fosfata v krvi, zvišanje koncentracij kalcija, sečne kisline, kalija, bilirubina ali C-reaktivnega proteina v krvi),
English: While taking Kyprolis and for 90 days after stopping treatment, you should use a condom even if your partner is pregnant.
Slovenian: Med zdravljenjem z zdravilom Kyprolis in še 90 dni po koncu zdravljenja morate uporabljati kondom, tudi če je vaša partnerka noseča.
English: Based on its mechanism of action and findings in animals, Kyprolis can cause foetal harm when administered to a pregnant woman.
Slovenian: Glede na mehanizem delovanja in izsledke pri živalih lahko zdravilo Kyprolis škoduje plodu, če je uporabljeno pri nosečnici.
English: While taking Kyprolis, and for 30 days after stopping treatment you should use a suitable method of contraception to ensure you do not become pregnant.
Slovenian: Med jemanjem zdravila Kyprolis in 30 dni po koncu zdravljenja z njim morate uporabljati ustrezno kontracepcijsko zaščito in tako poskrbeti, da ne zanosite.
English: This may impair your ability to drive or operate machines.
Slovenian: To lahko poslabša vašo sposobnost upravljanja vozil in strojev.
English: • Stop dose If recovered to ≥ 10 x 109/L and/or bleeding is controlled continue at same dose level
Slovenian: • Prekinite uporabo Če se število ponovno poveča na ≥ 10 x 109/l in/ali je krvavitev obvladana, nadaljujte z isto ravnjo odmerka
English: Kyprolis is used to treat adult patients with multiple myeloma who have had at least one previous treatment for this disease.
Slovenian: Zdravilo Kyprolis je namenjeno za zdravljenje odraslih bolnikov z diseminiranim plazmocitomom, ki so imeli vsaj eno predhodno zdravljenje te bolezni.
English: • Low white blood cell count, which may decrease your ability to fight infection and may be associated with fever
Slovenian: • nizko število belih krvnih celic, ki lahko zmanjša sposobnost za premagovanje okužb in ga lahko spremlja zvišana telesna temperatura,
English: The highest non-severely toxic dose of 0.5 mg/kg in monkeys resulted in interstitial inflammation in the kidney along with slight glomerulopathy and slight heart inflammation.
Slovenian: Največji odmerek, ki ni hudo toksičen, 0,5 mg/kg, je pri opicah povzročil intersticijsko vnetje v ledvici sočasno z rahlo glomerulopatijo in rahlim vnetjem v srcu.
English: In vitro studies indicated that carfilzomib did not induce human CYP3A4 in cultured human hepatocytes.
Slovenian: Študije in vitro kažejo, da karfilzomib v kulturah humanih hepatocitov ne inducira humanega CYP3A4.
English: • Absolute neutrophil count < 0.5 x 109/L (see section 4.4)
Slovenian: • Absolutno število nevtrofilcev < 0,5 x109/l (glejte poglavje 4.4)
English: It is not known if Kyprolis passes into breast milk in humans.
Slovenian: Ni znano, ali zdravilo Kyprolis pri človeku prehaja v materino mleko.
English: However, Kyprolis treatment may also be stopped if you experience side effects that cannot be managed.
Slovenian: Zdravljenje z zdravilom Kyprolis pa je mogoče tudi končati, če se pojavijo neobvladljivi neželeni učinki.
English: The overall incidence of venous thromboembolic events was higher in the Kyprolis arms of two phase 3 studies.
Slovenian: Celotna incidenca venskih tromboemboličnih dogodkov je bila v dveh študijah 3. faze večja v skupinah z zdravilom Kyprolis.
English: Proteasome inhibition was maintained for ≥ 48 hours following the first dose of carfilzomib for each week of dosing.
Slovenian: Zavrtje proteasomov se je po prvem odmerku karfilzomiba vsak teden odmerjanja ohranilo za ≥ 48 ur.
English: In vitro, at concentrations (3 µM) lower than those expected at therapeutic doses, carfilzomib inhibits the efflux transport of digoxin, a P-gp substrate, by 25%.
Slovenian: In vitro karfilzomib v koncentraciji (3 µM), ki je nižja od pričakovane ob terapevtskih odmerkih, za 25 % zavre iztočni prenos digoksina, ki je substrat P-gp.
English: Lenalidomide and dexamethasone are other medicines used to treat multiple myeloma.
Slovenian: Lenalidomid in deksametazon sta dve drugi zdravili, ki se uporabljata za zdravljenje diseminiranega plazmocitoma.
English: • Liver problems, including a history of hepatitis, fatty liver, or if you have ever been told your liver is not working properly
Slovenian: • Težave z jetri - če ste kdaj imeli hepatitis, zamaščena jetra ali so vam kdaj rekli, da vam jetra ne delujejo pravilno.
English: Lenalidomide is expected to be harmful to the unborn child. As Kyprolis is given in combination with lenalidomide, you must follow the Pregnancy Prevention Programme (see package leaflet for lenalidomide for information on pregnancy prevention and discuss with your doctor, pharmacist or nurse).
Slovenian: Zdravilo Kyprolis se uporablja v kombinaciji z lenalidomidom, zato morate ravnati v skladu s programom za preprečevanje nosečnosti (glejte navodilo za uporabo lenalidomida za informacije o preprečevanju nosečnosti ter se pogovorite z zdravnikom, farmacevtom ali z medicinsko sestro).
English: Thrombocytopenia was reported in approximately 34% of subjects in clinical studies with Kyprolis and approximately 20% of subjects had grade ≥ 3 events.
Slovenian: O trombocitopeniji so poročali pri približno 34 % bolnikov v kliničnih študijah z zdravilom Kyprolis in približno 20 % bolnikov je imelo dogodke ≥ 3. stopnje.
English: From cycle 13, the day 8 and 9 doses of Kyprolis are omitted.
Slovenian: Od 13. ciklusa dalje se odmerka zdravila Kyprolis 8. in 9. dan ne uporabljata več.
English: Carfilzomib caused embryo-foetal toxicity in pregnant rabbits at doses that were lower than in patients receiving the recommended dose.
Slovenian: Karfilzomib je imel embrio-fetalne toksične učinke pri brejih samicah kuncev v odmerkih, manjših od priporočeni odmerkov, ki so jih prejemali bolniki.
English: As Kyprolis is administered in combination with other medicinal products, refer to their summaries of product characteristics for additional contraindications.
Slovenian: Ker je zdravilo Kyprolis uporabljeno v kombinaciji z drugimi zdravili, glejte njihove povzetke glavnih značilnosti zdravila za dodatne kontraindikacije.
English: Those findings were reported at 6 mg/m2 which are below the recommended dose in humans of 27 mg/m2.
Slovenian: O teh ugotovitvah so poročali pri odmerkih 6 mg/m2, ki so pod priporočenim odmerkom pri človeku 27 mg/m2.
English: Ensure that patients are well hydrated before administration of Kyprolis in cycle 1, and in subsequent cycles as needed (see section 4.2).
Slovenian: Poskrbite, da bo bolnik pred uporabo zdravila Kyprolis v 1. ciklusu in nadaljnjih ciklusih dobro hidriran, kot je potrebno (glejte poglavje 4.2).
English: • Numbness, tingling, or decreased sensation in hands and/or feet
Slovenian: • omrtvičenost, mravljinčenje ali zmanjšano zaznavanje v dlaneh in/ali stopalih,
English: PX-171-011 evaluated Kyprolis monotherapy versus a control arm (corticosteroids and cyclophosphamide).
Slovenian: Študija PX-171-011 je ocenila monoterapijo z zdravilom Kyprolis v primerjavi s kontrolno skupino (kortikosteroidi in ciklofosfamid).
English: • For patients on dialysis receiving Kyprolis, the dose is to be administered after the dialysis procedure
Slovenian: • Bolnikom, ki se zdravijo z dializo in prejemajo zdravilo Kyprolis, je treba odmerek dati po dializi
English: In animals, carfilzomib inhibited proteasome activity in blood and tissue and delayed tumour growth in models of multiple myeloma.
Slovenian: Pri živalih je karfilzomib zavrl proteasomsko aktivnost v krvi in tkivih ter je zakasnil rast tumorjev v modelih diseminiranega plazmocitoma.
English: While adequate hydration is required prior to dosing in cycle 1, all patients should be monitored for evidence of volume overload, especially patients at risk for cardiac failure.
Slovenian: Ker je pred uporabo v 1. ciklusu je potrebna ustrezna hidracija, je pri vseh bolnikih potrebno spremljati za znake volumske preobremenitve, še posebej bolnike s tveganjem za srčno popuščanje.
English: Carfilzomib was not mutagenic in the in vitro bacterial reverse mutation (Ames) test and was not clastogenic in the in vivo mouse bone marrow micronucleus assay.
Slovenian: Karfilzomib ni bil mutagen v preizkusu bakterijskih reverznih mutacij (Amesov test) in vitro, in vivo pa ni bil klastogen v mikrojedrnem preizkusu na kostnem mozgu miši.
English: Serum potassium levels should be monitored monthly, or more frequently during treatment with Kyprolis as clinically indicated and will depend on the potassium levels measured before the start of treatment, concomitant therapy used (e.g. medicinal products known to increase the risk of hypokalaemia) and associated comorbidities.
Slovenian: Med zdravljenjem z zdravilom Kyprolis je potrebno mesečno ali bolj pogosto, kot je klinično indicirano, spremljati koncentracije kalija v serumu, kar pa bo odvisno od koncentracij kalija, izmerjenih pred začetkom zdravljenja, sočasno uporabljenih zdravil (npr. zdravila, ki povečajo tveganje za hipokaliemijo) in povezanih sočasnih obolenj.
English: Concomitant medicinal products
Slovenian: Sočasno uporabljana zdravila
English: What Kyprolis is and what it is used for What you need to know before you use Kyprolis How to use Kyprolis
Slovenian: Kaj je zdravilo Kyprolis in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Kyprolis Kako uporabljati zdravilo Kyprolis Možni neželeni učinki
English: PHARMACEUTICAL FORM AND CONTENTS Powder for solution for infusion.
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA prašek za raztopino za infundiranje.
English: Patients with a BSA greater than 2.2 m2 should receive a dose based upon a BSA of 2.2 m2.
Slovenian: Bolniki s telesno površino nad 2,2 m2 morajo dobiti odmerek za telesno površino 2,2 m2.
English: Renal function should be monitored at least monthly or in accordance with accepted clinical practice guidelines, particularly in patients with lower baseline creatinine clearance.
Slovenian: Delovanje ledvic je treba spremljati vsaj mesečno ali v skladu s sprejetimi kliničnimi smernicami, še posebej pri bolnikih z nižjim izhodiščnim očistkom kreatinina.
English: PX-171-003A1 was a single-arm phase 2 study (N = 266; exposure to ≥ 2 prior therapies required), which met its primary efficacy endpoint of IRC-assessed ORR (22.9%).
Slovenian: Študija PX-171-003A1 je bila študija 2. faze z eno samo skupino (n = 266, zahtevani sta bili ≥ 2 predhodni zdravljenji), ki je dosegla svoj primarni opazovani dogodek učinkovitosti, kar zadeva ORR (22,9 %) po oceni neodvisnega strokovnega odbora.
English: Cardiac failure, myocardial infarction and myocardial ischaemia
Slovenian: Srčno popuščanje, miokardni infarkt in ishemija miokarda
English: PRES, formerly termed reversible posterior leukoencephalopathy syndrome (RPLS), is a rare, neurological disorder, which can present with seizure, headache, lethargy, confusion, blindness, altered consciousness, and other visual and neurological disturbances, along with hypertension, and the diagnosis is confirmed by neuro-radiological imaging.
Slovenian: PRES (v preteklosti imenovan sindrom reverzibilne posteriorne levkoencefalopatije - RPLS) je redka nevrološka motnja, ki se lahko pokaže s konvulzijami, glavobolom, letargijo, zmedenostjo, slepoto, spremenjeno zavestjo ter drugimi vizualnimi in nevrološkimi motnjami, skupaj s hipertenzijo.
English: If tolerated, patients received 56 mg/m2 starting in cycle 2.
Slovenian: V primeru prenašanja so bolniki dobili odmerek 56 mg/m2 z začetkom v 2. ciklusu.
English: The study did not meet its primary efficacy endpoint of demonstrating superiority of Kyprolis monotherapy over the active control arm in overall survival (HR = 0.975 [95% CI: 0.760-1.249]).
Slovenian: Študija ni dosegla svojega primarnega opazovanega dogodka učinkovitosti - dokaza superiornosti monoterapije z zdravilom Kyprolis pred skupino, kontrolirano z učinkovino, kar zadeva celokupno preživetje (HR = 0,975 [95 % IZ: 0,760-1,249]).
English: 6.6 Special precautions for disposal and other handling General precautions
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom Splošni varnostni ukrepi
English: Carfilzomib administered to pregnant rats during the period of organogenesis was not teratogenic at doses up to 2 mg/kg/day, which is approximately half the recommended dose in humans of 27 mg/m2 based on BSA.
Slovenian: Karfilzomib, uporabljen pri brejih podganah med obdobjem organogeneze, ni bil teratogen v odmerkih do 2 mg/kg/dan, kar je približno polovica na podlagi telesne površine priporočenega odmerka pri človeku 27 mg/m2.
English: • Stop until resolved or returned to baseline
Slovenian: • Prekinite odmerek dokler ne mine ali se ne vrne na izhodiščno vrednost
English: It cannot be excluded that the efficacy of oral contraceptives may be reduced during carfilzomib treatment (see section 4.5).
Slovenian: Ni mogoče izključiti zmanjšanja učinkovitosti peroralnih kontraceptivov med zdravljenjem s karfilzomibom (glejte poglavje 4.5).
English: Male patients must use effective contraception measures during and for 3 months following treatment if their partner is pregnant or of childbearing potential and not using effective contraception (refer to section 4.6).
Slovenian: Moški morajo uporabljati učinkovito kontracepcijo med zdravljenjem in še 3 mesece po njem, če je njihova partnerica noseča ali je v rodni dobi in ne uporablja učinkovite kontracepcije (glejte poglavje 4.6).
English: If your partner becomes pregnant whilst you are taking Kyprolis or within 90 days after stopping treatment, notify your doctor or nurse immediately.
Slovenian: Če vaša partnerka med vašim zdravljenjem z zdravilom Kyprolis ali v 90 dneh po koncu zdravljenja zanosi, morate takoj obvestiti zdravnika ali medicinsko sestro.
English: • Stop dose If recovered to ≥ 0.5 x 109/L, continue at same dose level
Slovenian: • Prekinite uporabo Če se število ponovno poveča na ≥ 0,5 x 109/l, nadaljujte z isto ravnjo odmerka
English: Kyprolis is for single use only.
Slovenian: Zdravilo Kyprolis je samo za enkratno uporabo.
English: In clinical studies, hypertension adverse events occurred in approximately 20% of subjects and 7.5% of subjects had grade ≥ 3 hypertension events, but hypertensive crises occurred in < 0.5% of subjects.
Slovenian: V kliničnih študijah se je hipertenzija kot neželen učinek pojavila pri približno 20 % preiskovancev; 7,5 % bolnikov je imelo hipertenzivne dogodke ≥ 3. stopnje, toda hipertenzivne krize so se pojavile pri < 0,5 % preiskovancev.
English: How to use Kyprolis
Slovenian: Kako uporabljati zdravilo Kyprolis
English: Signs and symptoms of TTP/HUS should be monitored for.
Slovenian: Bolnike je treba spremljati za znake in simptome TTP/HUS.
English: The PL is updated accordingly.
Slovenian: V skladu s tem se posodobi tudi navodilo za uporabo.
English: • Heart problems, including a history of chest pain (angina), heart attack, irregular heartbeat, high blood pressure or if you have ever taken a medicine for your heart
Slovenian: • Težave s srcem - če ste kdaj imeli bolečine v prsnem košu (angino pektoris), srčni infarkt, neredno bitje srca, visok krvni tlak ali ste jemali zdravila za srce.
English: A thorough assessment for cardiovascular risk factors prior to starting treatment is recommended.
Slovenian: Pred začetkom zdravljenja je priporočena temeljita ocena dejavnikov tveganja za razvoj bolezni srca in ožilja.
English: A pre-planned overall survival (OS) analysis was performed after 246 deaths in the KRd arm and 267 deaths in the Rd arm.
Slovenian: Vnaprej načrtovana analiza celokupnega preživetja (OS) je bila opravljena po 246 smrtih v skupini s KRd in po 267 smrtih v skupini z Rd. Mediani čas spremljanja je bil približno 67 mesecev.
English: Liver enzymes and bilirubin should be monitored at treatment initiation and monthly during treatment with carfilzomib, regardless of baseline values.
Slovenian: Jetrne encime in bilirubin je treba spremljati ob uvedbi zdravljenja in nato vsak mesec med zdravljenjem s karfilzomibom, ne glede na izhodiščne vrednosti.
English: Dexamethasone (mg)
Slovenian: Deksametazon (mg)
English: Kyprolis is supplied in a glass vial as a white to off-white powder for solution for infusion, which is reconstituted (dissolved) before use.
Slovenian: Zdravilo Kyprolis je na voljo v steklenih vialah kot bel ali skoraj bel prašek za raztopino za infundiranje, ki ga je treba pred uporabo rekonstituirati (raztopiti).
English: Thus, there are limited data for Kyprolis in combination with lenalidomide and dexamethasone in patients with creatinine clearance (CrCL < 50 mL/min).
Slovenian: Zato so podatki o uporabi zdravila Kyprolis v kombinaciji z lenalidomidom in deksametazonom pri bolnikih z očistkom kreatinina (CrCl < 50 ml/min) omejeni.
English: Study eligibility criteria allowed patients previously treated with carfilzomib (n = 3) or bortezomib (n = 502) to be enrolled as long as patients had at least a partial response (PR) to prior proteasome inhibitor therapy, were not removed from proteasome inhibitor therapy due to toxicity, and had at least a 6-month proteasome inhibitor treatment-free interval from last dose.
Slovenian: Merila primernosti za študijo so dovoljevala vključitev bolnikov, ki so bili predhodno zdravljeni s karfilzomibom (n = 3) ali bortezomibom (n = 502), če so imeli ti bolniki vsaj delen odziv (PRpartial response) na predhodno zdravljenje z zaviralcem proteasomov, če jim zdravljenja z zaviralcem proteasomov niso ukinili zaradi toksičnosti in če so imeli od zadnjega odmerka zaviralca proteasomov vsaj 6-mesečen interval, med katerim ga niso prejemali.
English: • Serious lung infection (pneumonia)
Slovenian: • resna okužba pljuč (pljučnica),
English: • Hepatitis B infection activated again (viral inflammation of the liver)
Slovenian: • ponovno aktivirana okužba s hepatitisom B (virusno vnetje jeter).
English: • Low blood pressure (hypotension)
Slovenian: • nizek krvni tlak (hipotenzija),
English: However, given that Kyprolis is administrated intravenously and is extensively metabolised, the pharmacokinetic profile of carfilzomib is unlikely to be affected by P-gp or BCRP inhibitors or inducers.
Slovenian: Ker pa se zdravilo Kyprolis daje intravensko in se izdatno presnovi, ni verjetno, da bi zaviralci ali induktorji P-gp ali BCRP vplivali na farmakokinetične značilnosti karfilzomiba.
English: In the first study the M14 metabolite, a peptide fragment and the most abundant circulating metabolite, increased 2- and 3-fold in patients with moderate and severe renal impairment, respectively, and 7-fold in patients requiring dialysis (based on AUClast).
Slovenian: V prvi študiji se je presnovek M14, fragment peptida in najbolj obilen presnovek v obtoku, pri bolnikih z zmerno okvaro ledvic povečal 2-krat, pri bolnikih s hudo okvaro ledvic 3-krat, ter 7-krat pri bolnikih na dializi (na podlagi AUClast).
English: A total of 929 patients with relapsed or refractory multiple myeloma who had received 1 to 3 prior lines of therapy were enrolled and randomised (464 in the Kd arm; 465 in the Vd arm).
Slovenian: Zajeli in randomizirali so skupno 929 bolnikov z recidivnim ali refraktarnim diseminiranim plazmocitomom, ki so prejeli od 1 do 3 predhodne linije zdravljenja (464 bolnikov v skupini Kd, 465 v skupini Vd).
English: • A side effect called tumour lysis syndrome, which can be caused by the rapid breakdown of tumour cells and may cause irregular heartbeat, kidney failure or abnormal blood test results
Slovenian: • Neželen učinek, imenovan sindrom lize tumorja; povzroči ga lahko hitra razgradnja tumorskih celic in njegova posledica so lahko neredno bitje srca, odpoved ledvic ali nenormalni izvidi preiskav krvi.
English: Following intravenous administration of doses ≥ 15 mg/m2, carfilzomib was rapidly cleared from the systemic circulation with a half-life of ≤ 1 hour on day 1 of cycle 1.
Slovenian: Po intravenski uporabi odmerkov ≥ 15 mg/m2 se je karfilzomib 1. dan 1. ciklusa hitro izločil iz sistemskega obtoka z razpolovnim časom ≤ 1 uro.
English: • Viral infection
Slovenian: • virusna okužba,
English: Evaluate dyspnoea to exclude cardiopulmonary conditions including cardiac failure and pulmonary syndromes.
Slovenian: Dispnejo diagnostično opredelite, da boste izključili kardio-pulmonalne bolezni in motnje, vključno s srčnim popuščanjem in pljučnimi sindromi.
English: Female patients of child bearing potential treated with Kyprolis (and/or their partners) must use effective contraception measures during and for one month following treatment.
Slovenian: Ženske v rodni dobi, ki se zdravijo z zdravilom Kyprolis (in/ali njihovi partnerji), morajo uporabljati učinkovito kontracepcijo med zdravljenjem in še en mesec po njem.
English: • If absolute neutrophil count returns to baseline grade and fever resolves, resume at the same dose level
Slovenian: • Če se absolutno število nevtrofilcev vrne na izhodiščno raven in zvišana telesna temperatura mine, nadaljujte z enako ravnjo odmerka
English: What Kyprolis looks like and contents of the pack
Slovenian: Izgled zdravila Kyprolis in vsebina pakiranja
English: No effects on reproductive tissues were noted during 28-day repeat-dose rat and monkey toxicity studies or in 6-month rat and 9-month monkey chronic toxicity studies.
Slovenian: Med 28-dnevnimi študijami toksičnosti ponavljajočih se odmerkov pri podganah in opicah ter med 6 mesečnimi študijami kronične toksičnosti pri podganah in 9 mesečnimi študijami kronične toksičnosti pri opicah niso ugotovili učinkov na reproduktivna tkiva.
English: Study eligibility criteria allowed a small subset of patients with myeloma refractory to bortezomib (n = 118) or lenalidomide (n = 57) to be enrolled.
Slovenian: Vključitveni kriteriji študije so dovolili vključitev majhne podskupine bolnikov z desiminiranim plazmocitomom, odpornim proti bortezomibu (n = 118) ali lenalidomidu (n = 57).
English: If Kyprolis is used during pregnancy, or if the patient becomes pregnant while taking this medicinal product, the patient should be apprised of the potential hazard to the foetus.
Slovenian: Če je zdravilo Kyprolis uporabljeno med nosečnostjo, ali če ženska med jemanjem zdravila Kyprolis zanosi, jo je treba seznaniti z možno ogroženostjo ploda.
English: It is unknown whether carfilzomib or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se karfilzomib/njegovi presnovki izločajo v materino mleko.
English: They should be monitored for clinical and laboratory signs of HBV reactivation during and after the end of treatment.
Slovenian: Med zdravljenjem in po končanem zdravljenju je treba spremljati klinične in laboratorijske znake ponovne aktivacije HBV.
English: The predominant metabolites measured in human plasma and urine, and generated in vitro by human hepatocytes, were peptide fragments and the diol of carfilzomib, suggesting that peptidase cleavage and epoxide hydrolysis were the principal pathways of metabolism.
Slovenian: Glavni presnovki, izmerjeni v humani plazmi in urinu, ki in vitro nastajajo v humanih hepatocitih, so bili peptidni fragmenti in diol karfilzomiba.