FrancophonIA/ELRC3.0 huggingface dataset:
English: How long to take Sandimmun
Slovenian: Kdaj jemati zdravilo Sandimmun
English: Sandimmun contains castor oil and ethanol
Slovenian: glejte tudi besedilo pod naslovom "Sandimmun vsebuje ricinusovo olje in etanol").
English: Pink, oval soft gelatin capsules Corn yellow, oblong soft gelatin capsules Dusty rose, oblong soft gelatin capsules
Slovenian: Mehke želatinske kapsule koruzno rumene barve in podolgovate oblike.
English: The total dose each day is usually between 2.5 mg per kilogram of your body weight and 5 mg per kilogram body weight.
Slovenian: - Celotni dnevni odmerek je običajno od 2,5 do 5 mg na kilogram telesne mase v dveh deljenih odmerkih.
English: Acute and chronic nephrotoxicity
Slovenian: Akutno in kronično toksično delovanje na ledvice
English: The total dose each day for adults is usually 5 mg per kilogram body weight.
Slovenian: Nefrotski sindrom - Celotni dnevni odmerek za odrasle je običajno 5 mg na kilogram telesne mase v dveh deljenih odmerkih.
English: Oedema, weight increase * Adverse events reported from post marketing experience where the ADR frequency is not known due to the lack of a real denominator.
Slovenian: Motnje reprodukcije in dojk redki menstrualne motnje, ginekomastija Splošne težave in spremembe na mestu aplikacije pogosti zvišana telesna temperatura, utrujenost občasni edemi, povečanje telesne mase * neželeni dogodki, o katerih so poročali na podlagi izkušenj v obdobju trženja zdravila in pri katerih pogostnost ni znana, ker ni mogoče določiti velikosti dejanskega imenovalca
English: Push the nozzle of the syringe into the white stopper.
Slovenian: Nastavek brizge vstavite v bel čep.
English: • Methotrexate.
Slovenian: • izpuščaj
English: Discontinuation of Sandimmun is recommended if hypertension developing during treatment cannot be controlled with appropriate therapy.
Slovenian: Sandimmun pride do hipertenzije, ki je z ustreznimi zdravili ni mogoče urediti.
English: Patients receiving calcineurin inhibitor (CNI) therapies, including ciclosporin and ciclosporincontaining regimens, are at increased risk of acute or chronic nephrotoxicity.
Slovenian: ki vključujejo ciklosporin, obstaja povečano tveganje za akutno ali kronično toksično delovanje na ledvice.
English: How to store Sandimmun
Slovenian: Shranjevanje zdravila Sandimmun
English: Rare side effects: These side effects may affect between 1 and 10 in every 10,000 people.
Slovenian: Redki neželeni učinki: Ti neželeni učinki se lahko pojavijo pri 1 do 10 od 10.000 ljudi.
English: Method of administration Oral use
Slovenian: NAVODILA ZA UPORABO
English: It may also be harmful if this medicine is given to children
Slovenian: To je lahko škodljivo za bolnike,
English: • High level of uric acid or patassium in your blood, low levels of magnesium in your blood.
Slovenian: • zvišana raven sečne kisline ali kalija v krvi, znižana raven magnezija v krvi Če vas kateri koli od teh učinkov huje prizadene, obvestite svojega zdravnika.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING
Slovenian: PODATKI NA ZUNANJI OVOJNINI IN PRIMARNI OVOJNINI ŠKATLA
English: if you have liver problems.
Slovenian: • če imate težave z ledvicami.
English: Each mark on the syringe is 0.1 ml.
Slovenian: Vsaka oznaka na brizgi pomeni 0,1 ml raztopine, ta volumen pa vsebuje 10 mg ciklosporina.
English: If you are not sure, talk to your doctor before taking Sandimmun.
Slovenian: Če ste negotovi, se pred začetkom jemanja zdravila Sandimmun posvetujte s svojim zdravnikom.
English: Tell your doctor if you are pregnant or intend to become pregnant.
Slovenian: težave z jetri ali če ste noseči ali dojite.
English: The dose can still be measured correctly with the syringe.
Slovenian: Prevelik odmerek zdravila lahko škoduje ledvicam.
English: • Changes in menstrual cycle, breast enlargement in men.
Slovenian: • motnje menstrualnega ciklusa, povečanje dojk pri moškem Če vas kateri koli od teh učinkov huje prizadene, obvestite svojega zdravnika.
English: Children and adolescents There is limited experience with Sandimmun in children.
Slovenian: Na voljo je le malo izkušenj z uporabo zdravila Sandimmun pri otrocih.
English: Medicines which may decrease the level of ciclosporin in your blood include: barbiturates (used to help you to sleep), some anti-convulsant medicines (such as carbamazepine or phenytoine), octreotide (used to treat acromegaly or neuroendorcrine tumours in the gut), anti-bacterial medicines used to treat tuberculosis, orlistat (used to help weight loss), herbal medicines containing St. John's wort, ticlopidine (used after a stroke), certain medicines which lower blood pressure (bosentan), and terbinafine (an anti-fungal medicine used to treat infections of the toes and nails).
Slovenian: določeni antikonvulzivi (na primer karbamazepin, fenitoin), oktreotid (za zdravljenje akromegalije ali nevroendokrinih tumorjev v črevesju), protibakterijska zdravila za zdravljenje tuberkuloze, orlistat (za zmanjševanje telesne mase), zeliščna zdravila, ki vsebujejo šentjanževko, tiklopidin (ki ga uporabljamo po možganski kapi), določena zdravila, ki znižujejo krvni tlak (bosentan) in terbinafin (protiglivično zdravilo, ki ga uporabljamo za zdravljenje okužb nohtov in med prsti na stopalih), • zdravila, ki lahko škodljivo vplivajo na ledvice, kot so protibakterijska zdravila (gentamicin,
English: Organ, bone marrow and stem cell transplantation The total dose each day is usually between 2 mg and 15 mg per kilogram body weight.
Slovenian: Psoriaza in atopijski dermatitis - Celotni dnevni odmerek je običajno od 2,5 do 5 mg na kilogram telesne mase v dveh deljenih odmerkih.
English: Bone marrow transplantation
Slovenian: Presaditev kostnega mozga
English: One ml oral solution contains 100 mg ciclosporin.
Slovenian: En ml vsebuje 100 mg ciklosporina.
English: Common side effects: These side effects may affect between 1 and 10 in every 100 people.
Slovenian: Pogosti neželeni učinki: Ti neželeni učinki se lahko pojavijo pri 1 do 10 od 100 ljudi.
English: Measuring your dose
Slovenian: Odmerjanje volumna
English: Medicines which may increase the level of ciclosporin in your blood include: antibiotics (such as erythromycin or azythromycin), anti-fungals (voriconazole, itraconazole), medicines used for heart problems or high blood pressure (diltiazem, nicardipine, verapamil, amiodarone), metoclopramide (used to stop sickness), oral contraceptives, danazol (used to treat menstrual problems), medicines used to treat gout (allopurinol), cholic acid and derivatives (used to treat gallstones), protease inhibitors used to treat HIV, imatinib (used to treat leukaemia or tumours), colchicine, telaprevir (used to treat hepatitis C).
Slovenian: zdravila, ki lahko zvišajo koncentracijo zdravila Sandimmunl: antibiotiki (na primer eritromicin, azitromicin), protiglivična zdravila (vorikonazol, itrakonazol), zdravila za zdravljenje bolezni srca in visokega krvnega tlaka (diltiazem, nikardipin, verapamil,
English: • Fever.
Slovenian: in etopozida.
English: ml.
Slovenian: OATP).
English: A 100 mg dose of Sandimmun contains 556 mg ethanol.
Slovenian: 100-miligramski odmerek zdravila Sandimmun vsebuje 556 mg etanola, kar ustreza skoraj 15 ml piva ali 5 ml vina.
English: Elderly patients should be treated only in the presence of disabling atopic dermatitis and renal function should be monitored with particular care.
Slovenian: Starejše bolnike je smiselno zdraviti samo, če imajo hudo obliko atopijskega dermatitisa.
English: Concomitant administration of dabigatran extexilate is not recommended due to the P-gp inhibitory activity of ciclosporin (see section 4.3).
Slovenian: Sočasna uporaba z dabigatran eteksilatom ni priporočena, ker ciklosporin lahko zavira delovanje
English: The total dose each day is usually between 3 mg per kilogram of your body weight and 5 mg per kilogram body weight.
Slovenian: Celotni dnevni odmerek je običajno med 3 in 5 mg na kilogram telesne mase in ga običajno prejmete v dveh deljenih odmerkih.
English: Sandimmun and associated names (see Annex I) 50 mg/ml concentrate for solution for infusion [See Annex I - To be completed nationally]
Slovenian: IME ZDRAVILA Sandimmun in povezana imena (glejte Prilogo I) 50 mg/ml koncentrat za raztopino za infundiranje
English: About 37% increase in AUC Cmax was observed when Sandimmun was administered with high-fat meal.
Slovenian: AUC Cmax za približno 37 %.
English: Elderly patients should be treated only in the presence of disabling psoriasis, and renal function should be monitored with particular care.
Slovenian: Starejše bolnike je smiselno zdraviti samo, če imajo hudo obliko psoriaze.
English: Oral administration
Slovenian: Peroralna uporaba
English: Low doses of Sandimmun should be used to treat mild, chronic GVHD.
Slovenian: Bolnika s kronično blago reakcijo presadka proti prejemniku je treba zdraviti z nizkimi odmerki zdravila Sandimmun.
English: Sandimmun concentrate for solution for infusion contains castor oil which may cause severe allergic reactions.
Slovenian: Zdravilo Sandimmun vsebuje makrogolglicerol ricinolat in etanol Zdravilo Sandimmun koncentrat za raztopino za infundiranje vsebuje makrogolglicerol ricinolat, ki lahko povzroča hude alergijske reakcije.
English: Paediatric use in non-transplantation indications
Slovenian: Uporaba zdravila Sandimmun za zdravljenje indikacij, ki niso povezane s presaditvijo, pri otrocih,
English: You might get swollen gums that might grow over your teeth if you are taking nifedipine during your treatment with ciclosporin.
Slovenian: • nifedipin (za zdravljenje visokega krvnega tlaka in bolečin v predelu srca): če v času jemanja ciklosporina jemljete tudi nifedipin, vam lahko otečejo dlesni oziroma se tkivo dlesni razširi preko zob,
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGINGANDTHE IMMEDIATE PACKAGING
Slovenian: PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU PRETISNI OMOTI
English: All inducers of CYP3A4 and/or P-glycoprotein are expected to decrease ciclosporin levels.
Slovenian: Zniževanje koncentracije ciklosporina je mogoče pričakovati pri vseh induktorjih CYP3A4 in/ali P
English: Muscle weakness, myopathy Renal and urinary disorders Very common
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti mialgija, mišični krči redki mišična šibkost, miopatija
English: Table 1: Adverse drug reactions from clinical trials Blood and lymphatic system disorders Common
Slovenian: Preglednica 1: Neželeni učinki zdravila iz kliničnih študij Bolezni krvi in limfatičnega sistema pogosti levkopenija občasni trombocitopenija, anemija redki hemolitično uremični sindrom, mikroangiopatska hemolitična anemija pogostnost neznana* trombotična mikroangiopatija, trombotična trombocitopenična purpura
English: If you stop taking Sandimmun Do not stop taking Sandimmun unless your doctor tells you to.
Slovenian: Če zgornje velja za vas, ne jemljite zdravila Sandimmun, ampak to povejte svojemu zdravniku.
English: Uncoloured glass (type I) ampoule.
Slovenian: 6.5 Vrsta ovojnine in vsebina ampule iz neobarvanega stekla (tipa I)
English: Haemolytic uraemic syndrome, microangiopathic haemolytic anaemia
Slovenian: FARMACEVTSKI PODATKI 6.1 Seznam pomožnih snovi brezvodni etanol makrogolglicerol ricinolat
English: QUALITATIVE AND QUANTITATIVE COMPOSITION 1 ml oral solution contains 100 mg ciclosporin.
Slovenian: 1 ml peroralne raztopine vsebuje 100 mg ciklosporina.
English: Bleeding can occur at any site and can be severe or even fatal.
Slovenian: Krvavitev se lahko pojavi na katerem koli mestu in je lahko huda ali celo smrtna.
English: This medicine is the same as Lixiana, which is already authorised in the European Union (EU).
Slovenian: To zdravilo je enako zdravilu Lixiana, ki je že odobreno v Evropski uniji (EU).
English: Thrombin is essential for blood clotting.
Slovenian: Trombin je nujno potreben za strjevanje krvi.
English: What measures are being taken to ensure the safe and effective use of Roteas?
Slovenian: Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Roteas?
English: The full EPAR for Roteas can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Roteas je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: Other information about Roteas
Slovenian: Druge informacije o zdravilu Roteas
English: This is a summary of the European public assessment report (EPAR) for Roteas.
Slovenian: To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Roteas.
English: It must also not be used in pregnant or breastfeeding women or together with another anticoagulant.
Slovenian: Prav tako se ne sme uporabljati pri nosečnicah in doječih materah ter skupaj z drugim antikoagulantom.
English: The effects were studied in one main study, which involved over 21,000 patients for an average of 2.5 years.
Slovenian: Njegove učinke so proučevali v eni glavni študiji z več kot 21 000 bolniki, ki so v njej v povprečju sodelovali 2,5 leta.
English: It is not intended to provide practical advice on how to use Roteas.
Slovenian: Povzetek ni namenjen zagotavljanju praktičnih nasvetov o njegovi uporabi.
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) decided that Roteas's benefits are greater than its risks and recommended that it be approved for use in the EU.
Slovenian: Odbor za zdravila za uporabo v humani medicini (CHMP) pri agenciji je zaključil, da so koristi zdravila Roteas večje od z njim povezanih tveganj, in priporočil, da se odobri za uporabo v EU.
English: Roteas is available as tablets (15, 30 and 60 mg) and can only be obtained with a prescription.
Slovenian: Zdravilo Roteas je na voljo v obliki tablet (15, 30 in 60 mg), njegovo predpisovanje in izdaja pa je le na recept.
English: Although there was greater a risk of bleeding from the mucosa (tissues lining body cavities such as the nose, gut and vagina), the Committee considered that the risk could be managed with appropriate measures.
Slovenian: Čeprav so opazili večje tveganje krvavitve iz sluznice (tkiv, ki obdajajo telesne odprtine, kot so nos, črevo in nožnica), je Odbor menil, da je tveganje mogoče obvladati z ustreznimi ukrepi.
English: This means that it blocks factor Xa, an enzyme that is involved in the production of thrombin.
Slovenian: To pomeni, da zavira faktor Xa, tj. encim, ki sodeluje pri tvorbi trombina.
English: With respect to safety, overall the risk of serious bleeding such as bleeding into the brain was reduced compared with warfarin, although there may be less difference where warfarin treatment is well managed.
Slovenian: Kar zadeva varnost, je bilo na splošno tveganje za resno krvavitev, kot je krvavitev v možganih, manjše kot pri uporabi varfarina, čeprav so lahko razlike manjše, kadar je zdravljenje z varfarinom dobro vodeno.
English: Roteas is an anticoagulant medicine (a medicine that prevents blood clotting) used in adults:
Slovenian: Zdravilo Roteas je antikoagulacijsko zdravilo (zdravilo za preprečevanje strjevanja krvi), ki se uporablja pri odraslih:
English: It is used in patients who have one or more risk factors, such as having had a previous stroke, high blood pressure, diabetes, heart failure or being 75 years old or over;
Slovenian: Uporablja se pri bolnikih z enim ali več dejavniki tveganja, kot so možganska kap v preteklosti, visok krvni tlak, sladkorna bolezen, srčno popuščanje ali starost 75 let ali več;
English: Further episodes were seen in 130 of 4,118 patients given edoxaban (3.2%) and in 146 of 4,122 given warfarin (3.5%).
Slovenian: Njun ponoven pojav so opazili pri 130 od 4 118 bolnikov, ki so prejemali edoksaban (3,2 %), in pri 146 od 4 122 bolnikov, ki so prejemali varfarin (3,5 %).
English: The company that markets Roteas will provide educational materials for doctors prescribing the medicine and an alert card for patients, explaining the risks of bleeding with the medicine and how to manage them.
Slovenian: Družba, ki trži zdravilo Roteas, bo zagotovila izobraževalno gradivo za zdravnike, ki bodo predpisovali zdravilo, in opozorilno kartico za bolnike, na kateri bodo pojasnjena tveganja krvavitve pri uporabi zdravila in navodila za njihovo obvladovanje.
English: What is Roteas and what is it used for?
Slovenian: Kaj je zdravilo Roteas in za kaj se uporablja?
English: What benefits of Roteas have been shown in studies?
Slovenian: Kakšne koristi je zdravilo Roteas izkazalo v študijah?
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Roteas have also been included in the summary of product characteristics and the package leaflet.
Slovenian: Priporočila in varnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Roteas upoštevati zdravstveni delavci in bolniki, so vključeni tudi v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo.
English: It will also carry out a study of the effects of the medicine in patients with atrial fibrillation and good kidney function.
Slovenian: Prav tako bo izvedla študijo o učinkih zdravila pri bolnikih z atrijsko fibrilacijo, katerih ledvice dobro delujejo.
English: What are the risks associated with Roteas?
Slovenian: Kakšna tveganja so povezana z zdravilom Roteas?
English: Why is Roteas approved?
Slovenian: Zakaj je bilo zdravilo Roteas odobreno?
English: For more information about treatment with Roteas, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Roteas preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: The company that makes Lixiana has agreed that its scientific data can be used for Roteas (‘informed consent').
Slovenian: Družba, ki proizvaja zdravilo Lixiana, se strinja, da se lahko znanstveni podatki o tem zdravilu uporabijo tudi za zdravilo Roteas („uporaba dokumentacije s soglasjem“).
English: • to prevent stroke (caused by blood clots in the brain) and systemic embolism (blood clots in other organs) in patients with non-valvular atrial fibrillation (irregular rapid contractions of the upper chambers of the heart).
Slovenian: • za preprečevanje možganske kapi (ki jo povzročajo krvni strdki v možganih) in sistemske embolije (krvnih strdkov v drugih organih) pri bolnikih z nevalvularno atrijsko fibrilacijo (hitrim nepravilnim krčenjem preddvorov srca).
English: Roteas must not be used in patients who are actively bleeding, have liver diseases that affect blood clotting, have severe uncontrolled high blood pressure or who have a condition putting them at significant risk of major bleeding.
Slovenian: Zdravilo Roteas se ne sme uporabljati pri bolnikih z aktivno krvavitvijo, boleznijo jeter, ki vpliva na strjevanje krvi, nenadzorovanim zelo visokim krvnim tlakom ali boleznijo, zaradi katere pri njih obstaja veliko tveganje za hude krvavitve.
English: Other common side effects are anaemia (low levels of red blood cells), rash and abnormal results in tests of liver function.
Slovenian: Drugi neželeni učinki so anemija (nizke ravni rdečih krvnih celic), izpuščaji in nenormalni izvidi preiskav delovanja jeter.
English: When another recommended definition of the type of stroke was used, embolism or stroke due to blood clots was seen in 143 patients given Roteas (0.9%) and 157 given warfarin (1%).
Slovenian: Ko so uporabili drugo priporočeno opredelitev vrste možganske kapi, so embolijo ali možgansko kap zaradi krvnih strdkov zabeležili pri 143 bolnikih, ki so prejemali zdravilo Roteas (0,9 %), in 157 bolnikih, ki so prejemali varfarin (1 %).
English: The most common side effects with Roteas (which may affect up to 1 in 10 people) are bleeding from skin and soft tissues, nose (epistaxis) and the vagina.
Slovenian: Najpogostejši neželeni učinki zdravila Roteas (ki se lahko pojavijo pri več kot 1 bolniku od 10) so krvavitev iz kože in mehkih tkiv ter krvavitve iz nosu (epistaksa) in nožnice.
English: The main measure of effectiveness was the rate of stroke or systemic embolism among the patients each year.
Slovenian: Glavno merilo učinkovitosti je bil delež možganske kapi ali sistemske embolije, ki so jo vsako leto zabeležili pri bolnikih.
English: By blocking factor Xa, the medicine reduces the levels of thrombin in the blood, which helps treat clots and reduce the risk of them forming in the arteries and veins and leading to DVT, pulmonary embolism, stroke or other organ damage.
Slovenian: Z zaviranjem faktorja Xa zdravilo Roteas zniža ravni trombina v krvi, s čimer pomaga odpraviti strdke in zmanjša tveganje, da bi se ti tvorili v arterijah in venah ter povzročili globoko vensko trombozo, pljučno embolijo, možgansko kap ali poškodbo drugih organov.
English: A first systemic embolism or stroke occurred in 182 patients given standard doses of Roteas and in 232 of those given warfarin, corresponding to annual rates for these events of around 1.2% and 1.5% respectively.
Slovenian: Prvi pojav sistemske embolije ali možganske kapi so zabeležili pri 182 bolnikih, ki so prejemali standardne odmerke zdravila Roteas, in 232 bolnikih, ki so prejemali varfarin, kar pomeni, da je bil letni delež teh dogodkov približno 1,2 % oziroma 1,5 %.
English: Dose adjustments may also need to be made in patients who are switched between Roteas and other anticoagulant medicines.
Slovenian: Odmerek je včasih treba prilagoditi tudi pri bolnikih, ki preidejo na zdravilo Roteas z drugih antikoagulantov in obratno.
English: For practical information about using Roteas, patients should read the package leaflet or contact their doctor or pharmacist.
Slovenian: Za praktične informacije o uporabi zdravila Roteas naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
English: For the full list of all side effects reported with Roteas, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Roteas, glejte navodilo za uporabo.
English: • to treat deep-vein thrombosis (DVT, a blood clot in a deep vein, usually in the leg) and pulmonary embolism (a clot in a blood vessel supplying the lungs), and to prevent DVT and pulmonary embolism from re-occurring.
Slovenian: • za zdravljenje globoke venske tromboze (GVT, tj. krvnega strdka v globoki veni, običajno v nogi) in pljučne embolije (strdka v krvni žili, ki oskrbuje pljuča) ter za preprečevanje njune ponovitve.
English: The active substance in Roteas, edoxaban, is a ‘factor Xa inhibitor'.
Slovenian: Zdravilna učinkovina v zdravilu Roteas, edoksaban, je zaviralec faktorja Xa.
English: Doses should be halved in patients with moderately or severely reduced kidney function, or low body weight or in those who are also taking certain medicines (known as P-gp inhibitors) that can interfere with the removal of edoxaban from the body.
Slovenian: Bolniki z zmerno ali hudo okvaro delovanja ledvic, bolniki z majhno telesno maso ali bolniki, ki sočasno jemljejo nekatera druga zdravila (imenovana zaviralci P-glikoproteina), ki lahko vplivajo na izločanje edoksabana iz telesa, morajo jemati polovične odmerke.
English: The main measure of effectiveness was the number of patients who had another episode of DVT or pulmonary embolism during the study period.
Slovenian: Glavno merilo učinkovitosti je bilo število bolnikov, pri katerih se je v času trajanja študije ponovno pojavila globoka venska tromboza ali pljučna embolija.
English: Treatment is continued while the benefit outweighs the risk of bleeding, which depends on the condition being treated and any existing risk factors.
Slovenian: Običajni odmerek je 60 mg enkrat na dan. Zdravljenje traja, dokler so njegove koristi večje od tveganja krvavitve, kar je odvisno od zdravljene bolezni in morebitnih obstoječih dejavnikov tveganja.
English: There was a trend for better results in patients with reduced kidney function than those whose kidney function was normal.
Slovenian: Izkazalo se je, da so bili rezultati boljši pri bolnikih z okvarjenim delovanjem ledvic kot pri bolnikih z normalnim delovanjem ledvic.