FrancophonIA/ELRC3.0 huggingface dataset:
English: The below list of examples of drug drug interactions is not comprehensive and therefore the label of each drug that is co-administered with darunavir should be consulted for information related to the route of metabolism, interaction pathways, potential risks, and specific actions to be taken with regards to co-administration.
Slovenian: Seznam primerov medsebojnega delovanja med posameznimi učinkovinami v spodnji preglednici ni popoln, zato je treba za vsako zdravilo, ki se jemlje sočasno z darunavirjem, pregledati podatke o poti presnove, interakcijah, morebitnih tveganjih in posebnih ukrepih ob sočasni uporabi.
English: Population pharmacokinetic analysis in HIV infected patients showed that darunavir pharmacokinetics are not considerably different in the age range (18 to 75 years) evaluated in HIV infected patients (n=12, age ≥ 65) (see section 4.4).
Slovenian: Populacijska analiza farmakokinetike pri bolnikih, okuženih s HIV, je pokazala, da farmakokinetika darunavirja ni bistveno drugačna v razponu starosti, ki so ga proučevali pri bolnikih, okuženih s HIV (od 18 do 75 let) (n = 12, starost ≥ 65) (glejte poglavje 4.4).
English: Skin rash (more often when used in combination with raltegravir), itching.
Slovenian: Kožni izpuščaj (pogostejši je, če se zdravilo uporablja v kombinaciji z raltegravirjem), srbenje.
English: Darunavir is extensively metabolised by the hepatic CYP system and almost exclusively by isozyme CYP3A4.
Slovenian: Darunavir se obsežno presnavlja z jetrnim encimskim sistemom CYP in skoraj izključno z izoencimom CYP3A4.
English: There were no new clinically relevant safety findings compared with the known safety profile of darunavir/ritonavir in HIV-1 infected adults (see sections 4.2, 4.4 and 5.2).
Slovenian: Novih, klinično pomembnih ugotovitev o varnosti v primerjavi z znanim varnostnim profilom zdravil darunavir/ritonavir pri odraslih, okuženih s HIV-1, ni bilo (glejte poglavja 4.2, 4.4 in 5.2).
English: Tell your doctor if you notice any musculoskeletal problems.
Slovenian: - Povejte svojemu zdravniku, če opazite težave s kostno-mišičnim sistemom.
English: In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Slovenian: - Poleg oportunističnih okužb se lahko po začetku jemanja zdravil za zdravljenje okužbe z virusom HIV pojavijo tudi avtoimunske bolezni (stanja, do katerih pride, ko imunski sistem napade zdravo telesno tkivo).
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Kljub temu da so ocenili, da je vzrokov več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, večjim indeksom telesne mase), so poročali o primerih osteonekroze, še posebej pri bolnikih z napredovalo boleznijo HIV in/ali dolgotrajno izpostavljenostjo kombinirani protiretrovirusni terapiji (CART - Combination Antiretroviral Therapy).
English: What Darunavir Krka is and what it is used for
Slovenian: Kaj je zdravilo Darunavir Krka in za kaj ga uporabljamo
English: If alternatives cannot be used, its use should only take place after medical evaluation and under close monitoring by your doctor for corticosteroid side effects.
Slovenian: Kadar ni možno uporabiti drugih zdravil, se lahko uporabljajo le po zdravniškem pregledu in ob natančnem zdravniškem spremljanju zaradi možnosti pojava neželenih učinkov, povezanih s kortikosteroidi.
English: Darunavir Krka works by reducing the amount of HIV in your body.
Slovenian: Zdravilo Darunavir Krka deluje tako, da zmanjša količino HIV v telesu.
English: The lowest rates of developing resistant HIV virus are observed in ART-naïve patients who are treated for the first time with darunavir in combination with other ART.
Slovenian: Najnižjo stopnjo razvoja odpornih virusov HIV so opazili pri bolnikih, ki niso imeli izkušenj z ART in so jih prvič zdravili z darunavirjem v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: Driving and using machines Do not operate machines or drive if you feel dizzy after taking Darunavir Krka.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Ne upravljajte strojev in ne vozite avtomobila, če ste po jemanju zdravila Darunavir Krka omotični.
English: α1-ADRENORECEPTOR ANTAGONIST Alfuzosin
Slovenian: ANTAGONISTI ADRENERGIČNIH RECEPTORJEV α1 alfuzosin
English: Tell your doctor if you have diabetes.
Slovenian: - Povejte svojemu zdravniku, če imate sladkorno bolezen.
English: This protein binding is concentrationdependent indicative for saturation of binding.
Slovenian: Ta vezava na protein je odvisna od koncentracije in kaže na nasičenje vezavnih mest.
English: Do not combine Darunavir Krka with any of the following medicines If you are taking any of these, ask your doctor about switching to another medicine.
Slovenian: Zdravila Darunavir Krka ne smete kombinirati z nobenim od naslednjih zdravil Če jemljete katero od naštetih zdravil, prosite zdravnika, naj vam predpiše drugo zdravilo.
English: No human data on the effect of darunavir on fertility are available.
Slovenian: O učinkih darunavirja na plodnost pri ljudeh ni podatkov.
English: ANTI-DIABETICS Metformin
Slovenian: ANTIDIABETIKI metformin
English: The combination may result in increased risk of cardiovascular adverse event with salmeterol, including QT prolongation, palpitations and sinus tachycardia.
Slovenian: salmeterolom lahko zveča tveganje za pojav srčnožilnih neželenih učinkov, vključno s podaljšanjem QT intervala, palpitacijami in sinusno tahikardijo.
English: Patients using oestrogens as hormone replacement therapy should be clinically monitored for signs of oestrogen deficiency.
Slovenian: Pri bolnikih, ki uporabljajo estrogene za nadomestno hormonsko zdravljenje, je treba spremljati znake pomanjkanja estrogenov.
English: The direction of the arrow for each pharmacokinetic parameter is based on the 90% confidence interval of the geometric mean ratio being within (↔), below (↓) or above (↑) the 80-125% range (not determined as “ND”).
Slovenian: Smer puščice je za vsak farmakokinetični parameter določena na osnovi 90 % intervala zaupanja geometričnega povprečnega razmerja, ki je znotraj (↔), pod (↓) ali nad (↑) območjem 80-125 % spremembe (ni podatka je prikazano z "ND").
English: Other medicines and Darunavir Krka Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
Slovenian: Druga zdravila in zdravilo Darunavir Krka Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
English: Unchanged darunavir accounted for approximately 41.2% and 7.7% of the administered dose in faeces and urine, respectively.
Slovenian: Nespremenjenega darunavirja v blatu je bilo približno 41,2 % danega odmerka, v seču pa 7,7 %.
English: Tablet dimension: 20 x 10 mm.
Slovenian: Velikost tablet: 20 x 10 mm.
English: Adverse reactions are listed by system organ class (SOC) and frequency category.
Slovenian: Neželeni učinki so navedeni spodaj po organskih sistemih (OS) in po kategoriji pogostnosti.
English: In deciding to initiate treatment with darunavir co-administered with low dose ritonavir, careful consideration should be given to the treatment history of the individual patient and the patterns of mutations associated with different agents.
Slovenian: Pri odločanju o uvedbi zdravljenja z darunavirjem skupaj z majhnim odmerkom ritonavirja je treba skrbno upoštevati zgodovino zdravljenja posameznega bolnika in vzorce mutacij, povezanih z različnimi učinkovinami.
English: Due to uncertainties regarding the rate of development of the human blood brain barrier and liver enzymes, darunavir with low dose ritonavir should not be used in paediatric patients below 3 years of age.
Slovenian: Ker stopnja razvoja hematoencefalne bariere in jetrnih encimov pri ljudeh ni zanesljivo določena, darunavirja skupaj z majhnim odmerkom ritonavirja ne smete uporabljati pri pediatričnih bolnikih, mlajših od 3 let.
English: You must take Darunavir Krka every day and always in combination with 100 milligram of ritonavir and with food.
Slovenian: Zdravilo Darunavir Krka morate jemati vsak dan in vedno skupaj s 100 mg ritonavirja in s hrano.
English: Darunavir FC was less than 10 for 90% of 3,309 clinical isolates resistant to amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir and/or tipranavir showing that viruses resistant to most PIs remain susceptible to darunavir.
Slovenian: FC darunavirja je manj kot 10 za 90 % od 3.309 kliničnih izolatov, odpornih proti amprenavirju, atazanavirju, indinavirju, lopinavirju, nelfinavirju, ritonavirju, sakvinavirju in/ali tipranavirju, kar pomeni, da virusi, odporni proti večini zaviralcev proteaz, ostanejo občutljivi za darunavir.
English: Cobicistat has not been studied in patients receiving dialysis, therefore, no recommendation can be made for the use of darunavir/cobicistat in these patients (see section 4.2).
Slovenian: Kobicistata niso preučevali pri bolnikih, ki se zdravijo z dializo, zato priporočil za uporabo kombinacije darunavir/kobicistat pri teh bolnikih ni mogoče podati (glejte poglavje 4.2).
English: As darunavir and ritonavir are highly bound to plasma proteins, it is unlikely that they will be significantly removed by haemodialysis or peritoneal dialysis.
Slovenian: Ker se darunavir in ritonavir v veliki meri vežeta na plazemske beljakovine, je malo verjetno, da bi ju lahko v večji meri odstranili s hemodializo ali peritonealno dializo.
English: However, for unbound (i.e. active) darunavir, the pharmacokinetic parameters were less reduced during pregnancy compared to postpartum, due to an increase in the unbound fraction of darunavir during pregnancy compared to postpartum.
Slovenian: Farmakokinetični parametri za nevezani (aktivni) darunavir so bili manj zmanjšani med nosečnostjo v primerjavi z obdobjem po porodu zaradi zvečanja nevezane frakcije darunavirja med nosečnostjo v primerjavi z obdobjem po porodu.
English: 800 milligram
Slovenian: 800 mg
English: In the setting of lack or loss of virological response, resistance testing should be performed.
Slovenian: V primeru premajhnega virološkega odziva ali neodziva je treba izvesti testiranje odpornosti proti darunavirju.
English: C-darunavir with ritonavir showed that approximately 7.7% of the administered dose of darunavir is excreted in the urine unchanged.
Slovenian: C označenega darunavirja z ritonavirjem so pokazali, da se približno 7,7 % danega odmerka darunavirja izloči s sečem v nespremenjeni obliki.
English: Some clinical studies suggest raltegravir may cause a modest decrease in darunavir plasma concentrations.
Slovenian: Nekatere klinične študije kažejo, da lahko raltegravir povzroči zmerno znižanje plazemskih koncentracij darunavirja.
English: In most cases, Darunavir Krka can be combined with anti-HIV medicines belonging to another class [e.g. NRTIs (nucleoside reverse transcriptase inhibitors), NNRTIs (non-nucleoside reverse transcriptase inhibitors), CCR5 antagonists and FIs (fusion inhibitors)].
Slovenian: Večinoma se zdravilo Darunavir Krka lahko uporablja skupaj z drugimi zdravili proti HIV, ki spadajo v druge skupine [npr. NRTI (nukleozidni zaviralci reverzne transkriptaze), NNRTI (nenukleozidni zaviralci reverzne transkriptaze), antagonisti CCR5 in FI (zaviralci fuzije)].
English: The frequency of this is unknown (see section 4.4).
Slovenian: Pogostnost osteonekroze ni znana (glejte poglavje 4.4).
English: The increased exposure to darunavir in HIV-1 infected patients compared to healthy subjects may be explained by the higher concentrations of α1acid glycoprotein (AAG) in HIV-1 infected patients, resulting in higher darunavir binding to plasma AAG and, therefore, higher plasma concentrations.
Slovenian: Zvečana izpostavljenost darunavirju pri bolnikih, okuženih s HIV-1 v primerjavi z zdravimi preiskovanci lahko razložimo z višjimi koncentracijami alfa-1 kislega glikoproteina (AAG) pri bolnikih, okuženih s HIV-1, kar je povzročilo večjo vezavo darunavirja na plazemski AAG in zato večje plazemske koncentracije.
English: (P-gp, BCRP and/or OATP1B1/3 inhibition)
Slovenian: (zaviranje P-gp, BCRP in/ali OATP1B1/3)
English: Both arms used an Optimised Background Regimen (OBR) consisting of at least 2 antiretrovirals (NRTIs with or without NNRTIs).
Slovenian: V obeh krakih preskušanja so uporabljali optimiziran osnovni režim zdravljenja (OBR), ki je vključeval najmanj 2 protiretrovirusni zdravili (NRTI z ali brez NNRTI).
English: Darunavir/ritonavir should be used during pregnancy only if the potential benefit justifies the potential risk (see sections 4.4, 4.6 and 5.2).
Slovenian: Kombinacijo zdravil darunavir/ritonavir se lahko uporablja med nosečnostjo le, če možna korist pretehta morebitno tveganje (glejte poglavja 4.4, 4.6 in 5.2).
English: What you need to know before you take Darunavir Krka
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Darunavir Krka
English: What is Darunavir Krka?
Slovenian: Kaj je zdravilo Darunavir Krka?
English: For co-administration with strong CYP3A4 inhibitors, the same recommendations apply independent of whether darunavir is boosted with ritonavir or with cobicistat (see section above).
Slovenian: Za sočasno uporabo z močnimi zaviralci CYP3A4 veljajo enaka priporočila, ne glede na to, ali je darunavir okrepljen z ritonavirjem ali s kobicistatom (glejte poglavje zgoraj).
English: Increasing baseline darunavir fold change in EC50 (FC) was associated with decreasing virologic response.
Slovenian: Povečevanje stopnje spremembe (FC - fold change) začetne vrednosti EC50 je bila povezana z zmanjšanim virološkim odzivom.
English: C-darunavir trial in healthy volunteers showed that a majority of the radioactivity in plasma after a single 400/100 mg darunavir with ritonavir dose was due to the parent active substance.
Slovenian: C, pri zdravih prostovoljcih, je pokazalo, da je bila večina radioaktivnosti, izmerjene v plazmi po enkratnem 400/100 mg odmerku darunavirja z ritonavirjem posledica matične učinkovine.
English: Concomitant use with strong CYP3A inducers is contraindicated, since these may reduce the exposure to cobicistat and darunavir leading to loss of therapeutic effect.
Slovenian: Sočasna uporaba z močnimi induktorji CYP3A je kontraindicirana, ker lahko le ti zmanjšajo izpostavljenost kobicistatu in darunavirju in povzročijo izgubo terapevtskega učinka.
English: Treatment with darunavir/cobicistat 800/150 mg during pregnancy results in low darunavir exposure (see section 5.2), which may be associated with an increased risk of treatment failure and an increased risk of HIV transmission to the child.
Slovenian: Zdravljenje s kombinacijo darunavir/kobicistat 800/150 mg med nosečnostjo zmanjša izpostavljenost darunavirju (glejte poglavje 5.2), kar je lahko povezano s povečanim tveganjem za neuspešnost zdravljenja in s povečanim tveganjem za prenos virusa HIV na otroka.
English: Voriconazole should not be combined with boosted darunavir unless an assessment of the benefit/risk ratio justifies the use of voriconazole.
Slovenian: Vorikonazol se ne sme uporabljati sočasno z okrepljenim darunavirjem, razen če ocena razmerja med koristmi in tveganjem upravičuje uporabo vorikonazola.
English: Didanosine is to be administered on an empty stomach, thus it should be administered 1 hour before or 2 hours after boosted darunavir given with food.
Slovenian: Didanozin je treba jemati na tešče, zato ga je potrebno zaužiti 1 uro pred ali 2 uri po odmerjanju okrepljenega darunavirja in hrane.
English: twice daily N=298
Slovenian: dvakrat na dan n = 298
English: In rodents the target organs identified were the haematopoietic system, the blood coagulation system, liver and thyroid.
Slovenian: Pri glodalcih so bili ugotovljeni naslednji tarčni organi hematopoetični sistem, koagulacijski sistem, jetra in ščitnica.
English: The table below shows the efficacy data of the 48 week and 96 week analyses from the ARTEMIS trial:
Slovenian: Preglednica prikazuje podatke analize učinkovitosti po 48 tednih in 96 tednih preskušanja ARTEMIS:
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Poročali so o primerih osteonekroze, še posebej pri bolnikih s splošno znanimi dejavniki tveganja, napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo CART.
English: A clinical study utilising a cocktail of medicinal products that are metabolised by cytochromes CYP2C9, CYP2C19 and CYP2D6 demonstrated an increase in CYP2C9 and CYP2C19 activity and inhibition of CYP2D6 activity in the presence of darunavir/ritonavir, which may be attributed to the presence of low dose ritonavir.
Slovenian: Klinična študija, v kateri so uporabljali mešanico učinkovin, ki se presnavljajo s citokromi CYP2C9, CYP2C19 in CYP2D6, je v prisotnosti učinkovin darunavir/ritonavir pokazala zvečanje aktivnosti CYP2C9 in CYP2C19 ter zmanjšanje aktivnosti CYP2D6, kar lahko pripišemo prisotnosti majhnega odmerka ritonavirja.
English: 4.4Special warnings and precautions for use
Slovenian: 4.4 Posebna opozorila in previdnostni ukrepi
English: ANTIPSYCHOTICS/NEUROLEPTICS Quetiapine
Slovenian: ANTIPSIHOTIKI/NEVROLEPTIKI kvetiapin
English: ART-experienced adult patients
Slovenian: Odrasli bolniki z izkušnjami z ART
English: Darunavir in combination with ritonavir has no or negligible influence on the ability to drive and use machines.
Slovenian: V kombinaciji z ritonavirjem darunavir nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: Ritonavir may decrease plasma concentrations of voriconazole.
Slovenian: Ritonavir lahko zniža plazemske koncentracije vorikonazola.
English: Fentanyl Oxycodone Tramadol
Slovenian: fentanil oksikodon tramadol
English: Bosentan is expected to decrease plasma concentrations of darunavir and/or its pharmacoenhancer.
Slovenian: Bosentan pričakovano zniža plazemske koncentracije darunavirja in/ali njegovih farmakokinetičnih ojačevalcev.
English: Increased plasma concentrations of lovastatin or simvastatin may cause myopathy, including rhabdomyolysis.
Slovenian: Zvišanje plazemskih koncentracij lovastatina in simvastatina lahko povzroči miopatijo, vključno z rabdomiolizo.
English: No pharmacokinetic data are available in patients with severe hepatic impairment.
Slovenian: Ni podatkov o farmakokinetiki darunavirja pri bolnikih z okvaro jeter.
English: Darunavir is primarily metabolised and eliminated by the liver.
Slovenian: Darunavir se presnavlja in izloča predvsem preko jeter.
English: Rosuvastatin 10 mg once daily rosuvastatin AUC ↑ 48% rosuvastatin Cmax ↑ 144%
Slovenian: rosuvastatin 10 mg enkrat na dan rosuvastatin AUC ↑ 48 % rosuvastatin Cmax ↑ 144 %
English: Darunavir/ritonavir (600/100 mg twice daily or 800/100 mg once daily) in combination with a background regimen was evaluated in a clinical trial of 36 pregnant women (18 in each arm) during the second and third trimesters, and postpartum.
Slovenian: Darunavir/ritonavir (600/100 mg dvakrat na dan ali 800/100 mg enkrat na dan) v kombinaciji z osnovnim režimom so ocenjevali v kliničnem preskušanju pri 36 nosečnicah (18 v vsaki skupini) med drugim in tretjim trimesečjem nosečnosti ter v obdobju po porodu.
English: If switching the pharmacoenhancer from ritonavir to cobicistat, caution is required during the first two weeks of treatment with darunavir/cobicistat, particularly if doses of any concomitantly administered medicinal products have been titrated or adjusted during use of ritonavir as a pharmacoenhancer.
Slovenian: Pri zamenjavi farmakokinetičnega ojačevalca ritonavirja s kobicistatom je prva dva tedna zdravljenja s kombinacijo učinkovin darunavir/kobicistat potrebna previdnost, še posebno če so bili odmerki katerega koli sočasno uporabljenega zdravila med uporabo ritonavirja kot farmakokinetičnega ojačevalca titrirani ali prilagojeni.
English: This guidance is based on the half-life of darunavir in the presence of ritonavir and the recommended dosing interval of approximately 24 hours.
Slovenian: To navodilo temelji na razpolovnem času darunavirja v prisotnosti ritonavirja in na priporočenem režimu odmerjanja na približno 24 ur.
English: This guidance is based on the 15 hour half-life of darunavir in the presence of ritonavir and the recommended dosing interval of approximately 12 hours.
Slovenian: To navodilo temelji na 15-urnem razpolovnem času darunavirja v prisotnosti ritonavirja in na priporočenem režimu odmerjanja na približno 12 ur.
English: 30 film-coated tablets 60 film-coated tablets 90 film-coated tablets 180 film-coated tablets
Slovenian: 30 filmsko obloženih tablet 60 filmsko obloženih tablet 90 filmsko obloženih tablet 180 filmsko obloženih tablet
English: Rash considered by the investigator to be drug-related occurred at similar rates.
Slovenian: Pojavnost izpuščaja, ki je bil po oceni raziskovalca povezan z zdravilom, je bila podobna.
English: HEPATITIS C VIRUS (HCV) DIRECT-ACTING ANTIVIRALS NS3-4A protease inhibitors
Slovenian: PROTIVIRUSNA ZDRAVILA Z NEPOSREDNIM DELOVANJEM NA VIRUS HEPATITISA C Zaviralci serinske proteaze NS3 4A elbasvir/grazoprevir
English: Darunavir in combination with ritonavir caused a reduction in the number of pups that exhibited the startle response on day 15 of lactation and a reduced pup survival during lactation.
Slovenian: Kombinacija darunavirja in ritonavirja je povzročila zmanjšanje števila mladičev, ki so izkazovali vznemirjenje ob 15. dnevu laktacije in zmanjšanje preživetja mladičev v času dojenja.
English: In case of safety issues, a further increase of the dosing interval for rifabutin and/or monitoring of rifabutin levels should be considered.
Slovenian: V primeru neželenih učinkov je treba pretehtati možnost dodatnega zmanjšanja pogostnosti odmerjanja rifabutina in/ali spremljanje koncentracije rifabutina.
English: Exposure to darunavir was higher in HIV-1 infected patients than in healthy subjects.
Slovenian: Izpostavljenost darunavirju je bila večja pri bolnikih okuženih s HIV-1, kot pri zdravih preiskovancih.
English: Cmax, ng/ml AUC12h, ng.h/ml Cmin, ng/ml n=11 for AUC12h
Slovenian: Cmax, ng/ml AUC12h, ng.h/ml Cmin, ng/ml n = 11 za AUC12h
English: During the Phase III clinical trial GS-US-216-130 with darunavir/cobicistat (N=313 treatment-naïve and treatment-experienced subjects), 66.5% of subjects experienced at least one adverse reaction.
Slovenian: V kliničnem preskušanju faze III (GS-US-216-130) s kombinacijo darunavir/kobicistat (n = 313 bolnikov, ki se še niso ali so se že zdravili s protiretrovirusnimi zdravili) je imelo 66,5 % preiskovancev vsaj en neželen učinek.
English: Darunavir/ritonavir should not be used in children below 3 years of age because of safety concerns (see sections 4.4 and 5.3).
Slovenian: Zdravili darunavir/ritonavir se ne smeta uporabljati pri otrocih, mlajših od 3 let, zaradi zadržkov glede varnosti (glejte poglavji 4.4 in 5.3).
English: In the study, patients who were at risk of discontinuing therapy due to intolerance of ritonavir oral solution (e.g. taste aversion) were allowed to switch to the capsule formulation.
Slovenian: V študiji so bolniki, pri katerih je obstajalo tveganje, da prekinejo zdravljenje zaradi slabega okusa peroralne raztopine ritonavirja, lahko prešli na jemanje kapsul.
English: Therapy should be initiated by a health care provider experienced in the management of HIV infection.
Slovenian: Terapijo sme uvesti samo zdravnik z izkušnjami z zdravljenjem okužbe z virusom HIV.
English: Coadministration with darunavir/ritonavir may cause a large increase in the concentration of these medicines.
Slovenian: Sočasna uporaba z zdraviloma darunavir/ritonavir lahko povzroči veliko zvišanje koncentracij teh zdravil.