FrancophonIA/ELRC3.0 huggingface dataset:
English: Low levels of radioactivity were measured in amniotic fluid and foetal tissues of pregnant rats administered
Croatian: Niska razina radioaktivnosti je izmjerena u amnionskoj tekućini i fetalnim tkivima skotnih štakorica kojima je primijenjen
English: Use DuoTrav for as long as your doctor has told you to.
Croatian: Koristite DuoTrav onoliko dugo koliko Vam je rekao Vaš liječnik.
English: DuoTrav can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma.
Croatian: DuoTrav može utjecati na druge lijekove koje uzimate, isto tako drugi lijekovi mogu utjecati na njega, uključujući i druge kapi za oko namijenjene liječenju glaukoma.
English: Do not use this medicine after the expiry date which is stated on the bottle label and carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na bočici i vanjskom pakiranju iza oznake „EXP“.
English: Timolol should not be used during pregnancy unless clearly necessary.
Croatian: Timolol se ne smije koristiti tijekom trudnoće, osim ako to doista nije nužno.
English: Following once-daily administration of DuoTrav PQ in healthy subjects (N=22) for 5 days, travoprost free acid was not quantifiable in plasma samples from the majority of subjects (94.4%) and generally was not detectable one hour after dosing.
Croatian: Nakon primjene jednom dnevno doziranih DuoTrav kapi (polikvaternij-1 kao konzervans) u zdravih ispitanika (N=22) kroz 5 dana, travoprost kao slobodna kiselina nije se mogla izmjeriti u uzorcima plazme većine ispitanika (94,4%) i nije se mogla otkriti ni u jednom uzorku jedan sat nakon doziranja.
English: Do not stop using DuoTrav without speaking to your doctor.
Croatian: Ne prekidajte s primjenom DuoTrav kapi bez da ste se savjetovali s Vašim liječnikom.
English: In clinical studies involving 2,170 patients treated with DuoTrav the most frequently reported treatment-related adverse reaction was ocular hyperaemia (12.0%).
Croatian: U kliničkim ispitivanjima, koje su uključile 2170 bolesnika liječenih DuoTravom najčešće zabilježena nuspojava povezana s terapijom bila je hiperemija oka (12,0%).
English: MedDRA preferred term
Croatian: MedDRA preporučeni pojam
English: The adverse reactions listed in the table below were observed in clinical studies or with post-marketing experience.
Croatian: Nuspojave navedene u tablici ispod zabilježene su u kliničkim ispitivanjima ili nakon stavljanja lijeka u promet.
English: • After using DuoTrav, press your finger into the corner of your eye by your nose for 2 minutes
Croatian: • Nakon ukapavanja DuoTrava, pritisnite prstom kut oka blizu nosa na 2 minute (slika 4).
English: While taking beta blockers, patients with a history of atopy or a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge with such allergens and unresponsive to the usual dose of adrenaline used to treat anaphylactic reactions.
Croatian: Tijekom uzimanja beta blokatora, bolesnici s anamnezom atopije ili teške anafilaktičke reakcije na različite alergene mogu jače reagirati kod ponovljenog susreta s alergenima i mogu ne reagirati na uobičajene doze adrenalina koje se upotrebljavaju za liječenje anafilaktičke reakcije.
English: Reproduction toxicity studies with timolol showed delayed foetal ossification in rats with no adverse effects on postnatal development (7000 times the clinical dose) and increased foetal resorptions in rabbits (14000 times the clinical dose).
Croatian: Studije reproduktivne toksičnosti timolola pokazale su odgođeno okoštavanje fetusa štakora, bez štetnih učinaka na postporođajni razvoj (7000 puta kliničke doze) i povećanu resorpciju u fetusa kunića (14000 puta kliničke doze).
English: Beta blockers should be administered with caution in patients subject to spontaneous hypoglycaemia or in patients with labile diabetes, as beta blockers may mask the signs and symptoms of acute hypoglycaemia.
Croatian: Beta blokatori se moraju primjenjivati s oprezom kod bolesnika podložnih spontanoj hipoglikemiji ili kod bolesnika s nereguliranim dijabetesom jer beta blokatori mogu prikriti znakove i simptome akutne hipoglikemije.
English: Beta blockers may increase the hypoglycaemic effect of antidiabetic medicinal products.
Croatian: Beta blokatori mogu povećati hipoglikemijski učinak antidijabetičkih lijekova.
English: Respiratory reactions, including death due to bronchospasm in patients with asthma, have been reported following administration of some ophthalmic beta blockers.
Croatian: Respiratorne reakcije, uključujući smrt zbog bronhospazma kod bolesnika sa astmom zabilježene su nakon lokalne primjene u oko nekih beta blokatora.
English: DuoTrav is indicated in adults for the decrease of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta blockers or prostaglandin analogues (see section 5.1).
Croatian: DuoTrav je indiciran kod odraslih za sniženje intraokularnog tlaka (IOT) kod bolesnika s glaukomom otvorenog kuta ili očnom hipertenzijom koji nedovoljno reagiraju na lokalne beta blokatore ili analoge prostaglandina (vidjeti dio 5.1).
English: A statistically superior reduction in morning mean IOP (08:00, 24 hours after the last dose of DuoTrav) was observed compared to travoprost at all visits throughout the study.
Croatian: Statistički veće sniženje prosječnog jutarnjeg IOT (8 , 24 sata nakon posljednje doze DuoTrav kapi) zamijećena je u usporedbi s travoprostom na svim kontrolama kroz studiju.
English: Tonography and fluorophotometry studies in man suggest that its predominant action is related to reduced aqueous humour formation and a slight increase in outflow facility.
Croatian: Tonografske i fluorofotometrijske studije kod čovjeka sugeriraju da je prevladavajući učinak povezan sa smanjenjem proizvodnje očne vodice i blagim povećanjem otjecanja.
English: The systemic metabolic pathways parallel those of endogenous prostaglandin F2 which are characterised by reduction of the 13-14 double bond, oxidation of the 15-hydroxyl and -oxidative cleavages of the upper side chain.
Croatian: Sustavni metabolički putevi odgovaraju onima za endogeni prostaglandin F2α koji je karakteriziran redukcijom dvostruke veze 13-14, oksidacijom 15-hidroksil i β-oksidativnom cijepanju gornjeg bočnog lanca.
English: There are no or limited amount of data from the use of DuoTrav or the individual components in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni DuoTrava ili individualnih sastojaka u trudnica ograničeni.
English: Travoprost free acid can be measured in the aqueous humour during the first few hours in animals and in human plasma only during the first hour after ocular administration of DuoTrav.
Croatian: Travoprost u obliku slobodne kiseline se može izmjeriti u očnoj vodici tijekom prvih par sati u životinja i u ljudskoj plazmi jedino tijekom prvog sata nakon primjene DuoTrav kapi u oko.
English: DuoTrav should not be used during pregnancy unless clearly necessary.
Croatian: DuoTrav se ne smije koristiti u trudnoći osim ako je očito neophodno.
English: Periorbital and lid changes, including deepening of the eyelid sulcus, have been observed with prostaglandin analogues.
Croatian: Periorbitalne i promjene na kapcima, uključujući produbljivanje sulkusa vjeđa, zabilježene su s analozima prostanglandina.
English: Timolol is a beta blocker which works by reducing the production of fluid within the eye.
Croatian: Timolol je beta blokator koji smanjuje stvaranje očne vodice unutar oka.
English: • cataract surgery.
Croatian: • operacija katarakte.
English: In patients with cardiovascular diseases (e.g. coronary heart disease, Prinzmetal's angina and cardiac failure) and hypotension, therapy with beta blockers should be critically assessed and therapy with other active substances should be considered.
Croatian: Kod bolesnika sa kardiovaskularnim bolestima (npr. koronarna bolest srca, Prinzmetalova angina i zatajenje srca) i hipotenzijom, potrebno je kritički procijeniti terapiju beta blokatorima i uzeti u obzir terapiju drugim djelatnim tvarima.
English: It is unknown whether travoprost from eye drops is excreted in human breast milk.
Croatian: Nije poznato izlučuje li se travoprost iz kapi za oko u majčino mlijeko.
English: • Do not touch your eye or eyelid, the surrounding areas or other surfaces with the dropper.
Croatian: • Izbjegavajte dodir kapaljke s okom ili vjeđom, okolnim područjima oka ili drugim površinama.
English: Travoprost, a prostaglandin F2α analogue, is a full agonist which is highly selective and has a high affinity for the prostaglandin FP receptor, and reduces the intraocular pressure by increasing the outflow of aqueous humour via trabecular meshwork and uveoscleral pathways.
Croatian: Travoprost, analog prostaglandina F2, potpuni je agonist koji je visoko selektivan i ima visoki afinitet za prostaglandin FP receptor, i snižava intraokularni tlak povećanjem oticanja očne vodice kroz trabekulum i uveoskleralnim putem.
English: Timolol and its metabolites are primarily excreted by the kidneys.
Croatian: Timolol i njegovi metaboliti se primarno izlučuju putem bubrega.
English: Macular oedema has been reported during treatment with prostaglandin F2 analogues.
Croatian: Edem makule zabilježen je tijekom liječenja analozima prostangladina F2.
English: No specific drug interaction studies have been performed with travoprost or timolol.
Croatian: Nisu provedena posebna ispitivanja interakcija s travoprostom ili timololom.
English: Clinical effects
Croatian: Klinički učinci
English: Vertigo, tinnitus
Croatian: Vrtoglavica, tinitus
English: The non-inferiority of DuoTrav as compared to latanoprost 50 micrograms/mL + timolol 5 mg/mL in the mean IOP reduction was demonstrated across all time-points at all visits.
Croatian: Neinferiornost Duotrav kapi u usporedbi s latanoprostom 50 mikrograma/ml + timolol 5 mg/ml u prosječnom sniženju IOT dokazana je kroz sve vremenske točke praćenja na svim kontrolama.
English: • diabetes (as timolol may mask signs and symptoms of low blood sugar).
Croatian: • dijabetes (jer timolol može prikriti znakove i simptome niskog šećera u krvi).
English: If you forget to use DuoTrav
Croatian: Ako ste zaboravili primijeniti DuoTrav
English: This may cause side effects similar to those seen when beta-blocking medicines that are administered by mouth or by injection.
Croatian: Ovo može dovesti do pojave nuspojava sličnih onima zabilježenim s beta blokatorima primijenjenim kroz usta ili injekcijom.
English: DuoTrav contains two active substances: travoprost and timolol maleate.
Croatian: DuoTrav sadrži dvije djelatne tvari: travoprost i timolol maleat.
English: Mean IOP reductions were non-inferior, although numerically lower, to those achieved by concomitant therapy with travoprost 40 micrograms/mL dosed once daily in the evening and timolol 5 mg/mL dosed once daily in the morning.
Croatian: Prosječna sniženja IOT nisu bila inferiornija, iako brojčano niža, od onih postignutih istodobnom terapijom travoprostom 40 mikrograma/ml doziranim jednom dnevno navečer i timololom 5 mg/ml doziranim jednom dnevno ujutro.
English: Timolol is excreted in breast milk and has the potential to cause serious adverse reactions in the breast-fed infant.
Croatian: Timolol se izlučuje u majčino mlijeko i može izazvati ozbiljne nuspojave kod dojenčeta.
English: • coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, low blood pressure.
Croatian: • koronarnu bolest srca (simptomi mogu uključiti bol u prsnom košu ili stezanje, nedostatak zraka ili gušenje), zatajenje srca, nizak krvni tlak.
English: There is no experience of DuoTrav in inflammatory ocular conditions, nor in neovascular, angle-closure, narrow-angle or congenital glaucoma, and only limited experience in thyroid eye disease, in open-angle glaucoma of pseudophakic patients and in pigmentary or pseudoexfoliative glaucoma.
Croatian: Nema iskustava s DuoTrav kapima kod upalnih stanja oka, niti kod neovaskularnog glaukoma, glaukoma zatvorenog-uskog kuta ili kongenitalnog glaukoma, dok postoji samo ograničeno iskustvo kod tireoidne orbitopatije, kod glaukoma otvorenog kuta pseudofakičnih bolesnika i kod pigmentnog ili pseudoeksfolijativnog glaukoma.
English: Uncommon Bradycardia Rare
Croatian: Manje često Bradikardija Rijetko
English: The change in eye colour has predominantly been seen in patients with mixed coloured irides, i.e. blue-brown, grey-brown, yellow-brown and green-brown; however, it has also been observed in patients with brown eyes.
Croatian: Promjena boje oka uglavnom se opaža kod bolesnika s mješovito obojenim šarenicama, npr. plavosmeđe, sivosmeđe, žutosmeđe i zelenosmeđe te također kod bolesnika sa smeđim očima.
English: Prostatic specific antigen increased
Croatian: Povišenje vrijednosti prostata specifičnog antigena
English: Travoprost is a prodrug that undergoes rapid ester hydrolysis in the cornea to the active free acid.
Croatian: Travoprost je predlijek koji podvrgnut brzoj esterskoj hidrolizi u rožnici prelazi u formu aktivne slobodne kiseline.
English: Additional listed adverse reactions include reactions seen within the class of ophthalmic beta blockers.
Croatian: Dodatno navedene nuspojave uključuju reakcije zabilježene unutar skupine lokalno primijenjenih beta blokatora.
English: Do not use DuoTrav if you are breast-feeding.
Croatian: Ne koristite DuoTrav ako dojite.
English: Travoprost is a prostaglandin analogue which works by increasing the outflow of aqueous fluid from the eye, which lowers its pressure.
Croatian: Travoprost je analog prostaglandina koji djeluje tako da povećava otjecanje vodene tekućine iz oka i na taj način snižava očni tlak.
English: Each mL of solution contains polyquaternium-1 (POLYQUAD) 10 microgram, propylene glycol 5 mg and polyoxyethylene hydrogenated castor oil 40 1 mg (see section 4.4).
Croatian: Svaki ml otopine sadrži 10 mikrograma polikvaternija-1 (POLYQUAD), 5 mg propilenglikola i 1 mg polioksietilen hidrogeniranog ricinusovog ulja 40 (vidjeti dio 4.4)
English: In addition, signs and symptoms of beta blockade (e.g. bradycardia, hypotension, respiratory distress and hypoglycaemia) have been observed in the neonate when beta blockers have been administered until delivery.
Croatian: Dodatno, znakovi i simpotmi beta blokade (npr. bradikardija, hipotenzija, respiratorni distres i hipoglikemija) zabilježeni su kod novorođenčeta kada su beta blokatori bili primjenjivani do poroda.
English: Sinus bradycardia, sick sinus syndrome, including sino-atrial block, second- or third-degree atrioventricular block not controlled with pacemaker.
Croatian: Sinus bradikardija, sindrom bolesnog sinusnog čvora, uključujući sinus atrijski blok, atrioventrikularni blok drugog ili trećeg stupnja bez srčanog stimulatora.
English: DuoTrav may increase the length, thickness, colour and/or number of your eyelashes and may cause unusual hair growth on your eyelids.
Croatian: DuoTrav može uzrokovati produljenje i podebljanje trepavica, obojiti ih i/ili povećati njihov broj, te može uzrokovati neuobičajen rast dlaka na vjeđama.
English: No studies have been conducted with DuoTrav or with timolol 5 mg/mL eye drops in patients with hepatic or renal impairment.
Croatian: Nisu provedene studije s DuoTrav kapima niti s timololom 5 mg/ml kapima za oko u bolesnika s oštećenjem jetre ili bubrega.
English: Beta blockers may mask the signs of hyperthyroidism.
Croatian: Beta blokatori mogu prikriti znakove hipertireoze.
English: General side effects Ear and labyrinth disorders: dizziness with spinning sensation, ringing in the ears.
Croatian: Opće nuspojave Poremećaji uha i labirinta: vrtoglavica s osjećajem okretanja, zvonjava u ušima.
English: There is a potential for additive effects resulting in hypotension and/or marked bradycardia when ophthalmic beta-blocker solution is administered concomitantly with oral calcium channel blockers, beta-adrenergic blocking agents, antiarrhythmics (including amiodarone), digitalis glycosides, parasympathomimetics or guanethidine.
Croatian: Postoji mogućnost dodatnog učinka koji rezultira hipotenzijom i/ili naglašenom bradikardijom kad se lokalna otopina beta blokatora primjenjuje istodobno s peroralnim blokatorima kalcijevih kanala, beta adrenergičkim blokatorima, antiaritmicima (uključujući amiodaron), glikozidima digitalisa, parasimpatikomimeticima ili gvanetidinom.
English: Travoprost and timolol are absorbed through the cornea.
Croatian: Travoprost i timolol se apsorbiraju kroz rožnicu.
English: The incidence of side effects after administration to the eyes is lower than after administration by mouth or by injection.
Croatian: Incidencija nuspojava nakon primjene u oko niža je nego nakon primjene kroz usta ili u injekcijom.
English: Epidemiological studies have not revealed malformative effects but show a risk for intrauterine growth retardation when beta blockers are administered by the oral route.
Croatian: Epidemiološka istraživanja nisu otkrila učinak na pojavu malformacija ali su pokazala rizik za intrauterini zastoj rasta kod peroralne primjene beta blokatora.
English: Due to the beta-adrenergic component, timolol, the same types of cardiovascular, pulmonary and other adverse reactions seen with systemic beta-adrenergic blocking medicinal products may occur.
Croatian: Zbog beta adrenergičke komponente, timolola, mogu se pojaviti kardiovaskularne, plućne i druge nuspojave istog tipa kao i sa sistemskim beta adrenergičkim blokatorima.
English: Travoprost may gradually change eyelashes in the treated eye(s); these changes were observed in about half of the patients in clinical trials and include: increased length, thickness, pigmentation, and/or number of lashes.
Croatian: Ove su promjene opažene kod oko polovice bolesnika u kliničkim ispitivanjima i obuhvaćaju povećanje duljine, debljine, pigmentacije i/ili broja trepavica.
English: If you stop using DuoTrav
Croatian: Ako prestanete primjenjivati DuoTrav
English: • breathing problems, asthma or chronic obstructive pulmonary disease.
Croatian: • tegobe sa disanjem, astmu ili kroničnu opstruktivnu plućnu bolest.
English: CARTON FOR SINGLE BOTTLE 2.5 mL + CARTON FOR 3 x 2.5 mL BOTTLES + CARTON FOR 6 x 2.5 mL BOTTLES
Croatian: KUTIJA ZA JEDNU BOČICU OD 2,5 ml + KUTIJA ZA 3 BOČICE x 2,5 ml + KUTIJA ZA 6 BOČICA x 2,5 ml
English: Severe allergic rhinitis and corneal dystrophies.
Croatian: Teški alergijski rinitis i distrofija rožnice.
English: Signs and symptoms of ocular irritation (e.g. burning, stinging, itching, tearing, redness), choroidal detachment following filtration surgery (see section 4.4), decreased corneal sensitivity, diplopia
Croatian: Znakovi i simptomi iritacije oka (npr. žarenje, probadanje, svrbež, suzenje, crvenilo), ablacija žilnice nakon filtracijske operacije (vidjeti dio 4.4), smanjena osjetljivost rožnice, diplopija
English: Beta-blocking ophthalmological preparations may block systemic beta-agonist effects, e.g. of adrenaline.
Croatian: Oftalmički beta blokatori mogu blokirati sustavni beta agonistički učinak npr. adrenalina.
English: Like other medicines administered to the eyes, travoprost and timolol (a beta blocker) are absorbed into the blood.
Croatian: Poput ostalih lijekova primijenjenih u oko, travoprost i timolol (beta blokator) se apsorbiraju u krv.
English: Travoprost has been studied in patients with mild to severe hepatic impairment and in patients with mild to severe renal impairment (creatinine clearance as low as 14 mL/min).
Croatian: Travoprost je ispitivan kod bolesnika s blažim do teškim oštećenjem jetre kao i u bolesnika s blažim do teškim oštećenjem bubrega (klirens kreatinina do razine 14 ml/min).
English: The mean timolol steady-state Cmax was 1.34 ng/ml and Tmax was approximately 0.69 hours after once-daily administration of DuoTrav.
Croatian: Prosječna Cmax timolola u stanju dinamičke ravnoteže bila je 1,34 ng/ml i Tmax je bio približno 0,69 sata nakon jednom dnevno primjene DuoTrav kapi.
English: If more than one topical ophthalmic medicinal product is being used, the medicinal products must be administered at least 5 minutes apart (see section 4.5).
Croatian: Ako se primjenjuje više od jednog lijeka za lokalnu primjenu u oko, moraju se ukapati s najmanje 5 minuta razmaka između ukapavanja (vidjeti dio 4.5).
English: - The active substances are travoprost and timolol.
Croatian: - Djelatne tvari su travoprost i timolol.
English: What DuoTrav contains
Croatian: Što DuoTrav sadrži
English: In case of accidental ingestion, symptoms of overdose from systemic beta blockade may include bradycardia, hypotension, bronchospasm and heart failure.
Croatian: Kod slučajne ingestije simptomi povezani sa sustavnim predoziranjem beta blokatorom su bradikardija, hipotenzija, bronhospazam i zatajenje srca.
English: Beta-adrenergic blocking medicinal products have been reported to potentiate muscle weakness consistent with certain myasthenic symptoms (e.g. diplopia, ptosis and generalised weakness).
Croatian: Zabilježeno je da beta adrenergički blokatori mogu potencirati mišićnu slabost koja je u skladu s određenim simptomima mijastenije (npr. diplopija, ptoza i generalizirana slabost).
English: The side effects listed below include reactions seen with the class of beta blockers used for treating eye conditions or reactions seen with travoprost alone:
Croatian: Nuspojave niže navedene uočene pri primjeni beta blokatora za liječenje bolesti oka ili reakcije koje se vide samo sa travoprostom:
English: Only use DuoTrav in both eyes if your doctor told you to do so.
Croatian: Lijek primijenite u oba oka samo ako Vam je to savjetovao liječnik.
English: Caution is recommended when using DuoTrav in aphakic patients, pseudophakic patients with a torn posterior lens capsule or anterior chamber lenses, or in patients with known risk factors for cystoid macular oedema.
Croatian: Preporučuje se oprez kod primjene DuoTrav kapi u afakičnih bolesnika, pseudofakičnih bolesnika s rupturom stražnje kapsule leće ili prednje očne sobice, ili kod bolesnika s poznatim rizičnim faktorima za cistični edem makule.
English: In controlled clinical trials, periorbital and/or eyelid skin darkening in association with the use of travoprost has been reported.
Croatian: U kontroliranim kliničkim ispitivanjima prijavljeno je tamnjenje kože vjeđa i/ili periorbitalno tamnjenje povezano s primjenom travoprosta.
English: DuoTrav is a combination of two active substances, travoprost and timolol.
Croatian: DuoTrav je kombinacija dviju djelatnih tvari, travoprost i timolol.
English: In monkeys, administration of DuoTrav twice daily was shown to induce increased palpebral fissure and to increase iris pigmentation similar to that observed with ocular administration of prostanoids.
Croatian: Kod majmuna primjena DuoTrav kapi dvaput dnevno je pokazala da uzrokuje povećanje vjeđnog otvora i povećanje pigmentacije šarenice slično kao što je primijećeno s primjenom prostanoida u oko.
English: Timolol can be measured in human aqueous humour after ocular administration of timolol and in plasma for up to 12 hours after ocular administration of DuoTrav.
Croatian: Timolol se može izmjeriti u ljudskoj očnoj vodici nakon primjene u oko timolola i u plazmi kroz do 12 sati nakon primjene DuoTrav kapi u oko.
English: Muscular: increases in signs and symptoms of myasthenia gravis (muscle disorder), unusual sensations like pins and needles, muscle weakness/tiredness, muscle pain not caused by exercise, joint pain.
Croatian: Mišići: pogoršanje znakova i simptoma miastenije gravis (mišićni poremećaj), neuobičajen osjećaj probadanja tankim oštrim predmetima poput igle, mišićna slabost/umor, mišićna bol koja nije uzrokovana vježbanjem, bol u zglobovima.
English: One route yields an ethanolamine side chain on the thiadiazole ring and the other gives an ethanolic side chain on the morpholine nitrogen and a second similar side chain with a carbonyl group adjacent to the nitrogen.
Croatian: Jedan put je nastanak etanolamin postraničnog lanca na tiadiazolnom prstenu, a drugi je dodavanje jednog etanolnog postraničnog lanca na morfolinski dušik i drugi sličan postranični lanac sa karbonilnom grupom pridodan na dušik. t1/2 timolola iz plazme je 4 sata nakon primjene DuoTrav kapi u oko.