FrancophonIA/ELRC3.0 huggingface dataset:
English: In field studies, it reduced the flea comb counts by up to 98% in cats and 99% in dogs 90 days after treatment, as well as preventing flea eggs from hatching, and killing and preventing the development of flea larvae.
Estonian: Väliuuringutes vähendas Stronghold väljakammitud kirpude arvu 90 päeva pärast ravi kassidel kuni 98% ja koertel kuni 99% võrra, samuti takistas kirbuvastsete munast koorumist ja arenemist.
English: Selamectin activates special proteins called ‘chloride channels' on the surface of nerve and muscle cells of the parasite, allowing charged chloride particles to enter nerve cells and disrupting their normal electrical activity.
Estonian: Selamektiin aktiveerib parasiidi närvi- ja lihasrakkude pinnal olevaid teatud valke, kloriidikanaleid, mille tulemusena sisenevad kloriidioonid närvirakkudesse ja häirivad nende normaalset elektrilist talitlust.
English: Stronghold is an antiparasitic medicine that contains the active substance selamectin.
Estonian: Stronghold on parasiidivastane ravim, mis sisaldab toimeainena selamektiini.
English: Other information about Stronghold:
Estonian: Muu teave Strongholdi kohta
English: What is the risk associated with Stronghold?
Estonian: Mis riskid Strongholdiga kaasnevad?
English: Stronghold
Estonian: Stronghold selamektiin
English: The contents of the tube are squeezed onto the skin after parting the fur between the shoulder blades.
Estonian: Tuubi sisu pigistatakse nahale, olles eelnevalt lükanud koera seljal abaluude vahel karva laiali.
English: The effectiveness of Stronghold against the specified parasites was investigated in laboratory studies in cats and dogs.
Estonian: Strongholdi efektiivsust loetletud parasiitide suhtes uuriti kasside ja koerte laboriuuringutel.
English: How has Stronghold been studied?
Estonian: Kuidas Strongholdi uuriti?
English: If Stronghold comes into contact with the eyes, they should be flushed immediately with water and medical attention sought.
Estonian: Strohholdi sattumisel silma tuleb silmi otsekohe pesta veega ja pöörduda arsti poole.
English: Stronghold treatment was found to be effective after a single administration or repeated treatments at monthly intervals, depending on the type of infestation it was being used to treat or prevent.
Estonian: Uuringutes selgus, et ravi Strongholdiga on efektiivne pärast ühekordset manustamist või korduvat manustamist kuu aja tagant, olenevalt ravitava või ennetatava seisundi tüübist.
English: It must also not be used in cats that are suffering from another disease or that are weakened and underweight for their size and age.
Estonian: Storngholdi ei tohi kasutada ka muu haigusega, nõrgenenud ega vanuse kohta alakaalulistel kassidel.
English: What is Stronghold?
Estonian: Mis on Stronghold?
English: Stronghold causes temporary alopecia (hair loss) at the application site in less than 1 in 1,000 cats.
Estonian: Stronghold põhjustab kassidel manustamiskohal ajutist karvade väljalangemist vähem kui 1 loomal 1000st.
English: Field studies also showed that Stronghold was 100% effective in preventing heartworm disease in dogs and cats.
Estonian: Väliuuringutes tõendati, et Stronghold oli kassidel ja koertel südameusstõve ennetamisel 100% efektiivne.
English: In the treatment of sarcoptic mange in dogs, two treatments given 30 days apart were required to completely eliminate the mites in dogs.
Estonian: Koertel oli demodikoosi ravis vaja lestade täielikuks hävitamiseks kaht manustamiskorda vaheajaga 30 päeva.
English: What is Stronghold used for?
Estonian: Milleks Strongholdi kasutatakse?
English: Stronghold was also effective in the treatment of adult intestinal hookworms in cats, adult intestinal roundworms in cats and dogs, and biting lice in dogs and cats.
Estonian: Stronghold oli efektiivne ka täiskasvanud soolekidausside hävitamiseks kassidel, täiskasvanud sooleümarusside hävitamiseks kassidel ja koertel ning väiviliste hävitamiseks koertel ja kassidel.
English: What benefit has Stronghold shown during the studies?
Estonian: Milles seisneb uuringute põhjal Strongholdi kasulikkus?
English: to treat sarcoptic mange (scabies) in dogs.
Estonian: Koertel demodikoosi (vagellesttõve) raviks
English: Stronghold contains selamectin, which is an antiparasitic medicine that belongs to the ‘avermectin' class.
Estonian: Strong sisaldab toimeainena selamektiini, mis on avermektiinide rühma kuuluv parasiidivastane aine.
English: How does Stronghold work?
Estonian: Kuidas Stronghold toimib?
English: Stronghold is used to treat and prevent infestations with parasites that live on the skin or in the fur of cats and dogs, such as fleas and mites, as well as treating worm parasites that live inside the body.
Estonian: Strongholdi kasutatakse kasside ja koerte naha- ja karvastikuparasiitide (nt kirpude ja lestade) hävitamiseks ja tõrjeks ning seesmiste ussparasiitide hävitamiseks.
English: It is also effective in treating ear mites in cats and dogs.
Estonian: Stronghold oli efektiivne ka kassidel ja koertel kõrvas elavate lestade hävitamisel.
English: It can also be used as part of a treatment for flea allergy dermatitis (skin inflammation), to prevent heartworm disease in cats and dogs, to treat ear mites in cats and dogs, to treat adult intestinal roundworms and intestinal hookworms in cats, to treat adult intestinal roundworms in dogs,
Estonian: Kassidel ja koertel kõrvas elavate lestade hävitamiseks Kassidel täiskasvanud sooleümarusside ja soolekidausside hävitamiseks Koertel täiskasvanud sooleümarusside hävitamiseks Kassidel ja koertel väiviliste (teatud täitaolised välisparasiidid) hävitamiseks
English: There is no alternative available for this purpose in the EU at present.
Estonian: ELis ei ole praegu saadaval alternatiivset ravimit.
English: Hungary Ceva-Phylaxia Zrt.
Estonian: Ceva-Phylaxia Zrt.
English: SPECIAL WARNING(S), IF NECESSARY
Estonian: ERIHOIATUSED, KUI VAJALIK
English: Denmark Intervet Danmark A/S.
Estonian: Intervet Danmark A/S.
English: This value is used for the calculation of the initial PECsurfacewater value.
Estonian: Seda väärtust kasutati algse PECpinnavesi väärtuse arvutamiseks.
English: Labelling:
Estonian: Märgistus:
English: Consequently, the benefit-risk balance is considered positive.
Estonian: Järelikult on kasulikkuse ja riski suhe positiivne.
English: Thus, the PECsoil, and hence PECsurfacewater, could be conservatively reduced by 85% and not only by 69%.
Estonian: Seega võib PECpinnas ja PECpinnavesi väärtusi konservatiivselt väheneda 85% ja mitte üksnes 69% võrra.
English: A Phase I and a Phase II environmental risk assessment were conducted.
Estonian: Korraldati I ja II faasi keskkonnariski hindamise uuringud.
English: Therefore on 21 March 2013 Germany initiated a procedure under Article 35 of Directive 2001/82/EC for veterinary medicinal products containing altrenogest to be administered orally to pigs and horses.
Estonian: Seetõttu algatas Saksamaa 21. märtsil 2013 direktiivi 2001/82/EÜ artikli 35 kohase menetluse, mis käsitleb sigadele ja hobustele suukaudselt manustatavaid altrenogesti sisaldavaid veterinaarravimeid.
English: Denmark Ceva Animal Health A/S, Ladegårdsvej 2
Estonian: Ceva Animal Health A/S, Ladegårdsvej 2
English: D-85716
Estonian: 1a D-85716
English: The CVMP noted that measures are already in place to reduce runoff based on European and national legislation.
Estonian: Veterinaarravimikomitee märkis, et Euroopa ja liikmesriikide õigusaktide alusel on juba kehtestatud äravoolu vähendamise meetmed.
English: List of the names, pharmaceutical forms, strengths of the veterinary medicinal products, animal species, route of administration, marketing authorisation holders in the Member States
Estonian: Veterinaarravimite nimetuste, ravimvormide, tugevuste, loomaliikide, manustamisviiside ja müügiloa hoidjate loetelu liikmesriikides
English: B, et. 1, apt. 1
Estonian: B, et. 1, apt. 1 Sofia 1113
English: The results from STEP 4 ranged from 16 pg/l (R1) to 219 pg/l (R3).
Estonian: Etapi 4 tulemused olid vahemikus 16 pg/l (R1) kuni 219 pg/l (R3).
English: R4 is often used to cover a conservative run-off scenario in FOCUS-SW and consequently has been used for the exposure assessment for the FOCUS-SW STEP 3 calculations.
Estonian: R4 kasutatakse sageli FOCUS-SW konservatiivse äravoolustsenaariumina ning seetõttu on seda kasutatud kokkupuute hindamiseks FOCUS-SW etapi 3 arvutustes.
English: Belgium MSD Animal Health BVBA Lynx Binnenhof 5
Estonian: MSD Animal Health BVBA Lynx Binnenhof 5
English: It was concluded that for R1 and R4 scenarios there is no risk for contamination of surface water with altrenogest after spreading manure from treated animals onto cropland, while a risk cannot be excluded for R3-scenario.
Estonian: Järeldati, et R1 ja R4 stsenaariumide korral ei ole ohtu pinnavee saastumiseks altrenogestiga, kui ravitud loomade sõnnikut laotatakse viljapõllule, kuid R3 stsenaariumi korral ei saa riski välistada.
English: 03-715 Warsaw
Estonian: 03-715 Warsaw Poland
English: DK-7100 Vejle
Estonian: DK-7100 Vejle Denmark
English: Ceva Animal Health Ltd Unit 3 Anglo Office Park White Lion Road Amersham
Estonian: Ühendkuningriik Ceva Animal Health Ltd Unit 3 Anglo Office Park White Lion Road
English: 1200 Brussel
Estonian: 1200 Brussel Belgium
English: A PECsoil refined of 0.013 µg/kg was determined accordingly, resulting on an application rate of 0.000094 kg/ha.
Estonian: PECpinnasväärtuse korrigeerimine andis tulemuseks 0,013 µg/kg, mis andis laotusmääraks 0,000094 kg/ha.
English: Altrenogest is a synthetic steroidal hormone, an orally active progestogen.
Estonian: Altrenogest on sünteetiline steroidhormoon, suukaudselt toimiv progestogeen.
English: A survey of the national legislation in relation to Directive 91/676/EEC revealed that countries with a minimum distance of 1 and 2 m from the water body represent almost two-thirds of the total pig production in Europe.
Estonian: Direktiiviga 91/676/EÜ seotud liikmesriikide õigusaktide uuring näitas, et riikides, kus minimaalne kaugus veekogust on 1 kuni 2 meetrit, paikneb ligi kaks kolmandikku kogu Euroopa seakasvandustest.
English: Rue Olivier de Serres Angers Technopole 49071 Beaucouze Cedex France
Estonian: Prantsusmaa Intervet Rue Olivier de Serres Angers Technopole 49071 Beaucouze Cedex France
English: However, for buffer zone calculations, which represent the highest tier exposure scenario, the entire representative R-scenario set is recommended.
Estonian: Siiski on puhvertsooni arvutustes, mis kujutavad endast kõrgeima taseme kokkupuutestsenaariumi, soovitatav kasutada kogu R-stsenaariumide kogumit.
English: DK-2750 Ballerup
Estonian: DK-2750 Ballerup Denmark
English: Exposure studies
Estonian: Kokkupuute uuringud
English: 1130 Brussel
Estonian: 1130 Brussel Belgium
English: Poland Ceva Animal Health Polska Sp. z o.o.
Estonian: Ceva Animal Health Polska Sp. z o.o.
English: Bulgaria Ceva Animal Health Bulgaria, ul.
Estonian: Ceva Animal Health Bulgaria, ul.
English: Slovakia Ceva AH Slovakia Račianska 77, 831 02
Estonian: Ceva AH Slovakia Račianska 77, 831 02 Bratislava
English: Quality, target animal safety, user safety and residues were not assessed in this referral procedure.
Estonian: Esildismenetluses ei hinnatud kvaliteeti, sihtloomade ohutust, kasutajaohutust ega jääke.
English: The active substance altrenogest is a potent synthetic hormone which was demonstrated to affect reproduction in fish at very low concentrations.
Estonian: Toimeaine altrenogest on tugevatoimeline sünteetiline hormoon, millel on tõendatud mõju kalade reproduktiivsusele väga väikestes kontsentratsioonides.
English: STEP 1 resulted in a PECgroundwater being below the threshold value (0.1 µg/l), anticipating that a risk for groundwater could in principle be excluded.
Estonian: Etapp 1 andis tulemuseks PECpõhjavesi alla piirväärtuse (0.1 µg/l), millest tulenevalt võib riskid põhjaveele välistada.
English: Extrapolation of EC10 values was not possible, in line with the recommendations of the OECD 54 guideline on Current Approaches in the Statistical Analysis of Ecotoxicity Data: A Guidance to Application (2006)5.
Estonian: EC10 väärtuste ekstrapolatsioon ei olnud võimalik vastavalt OECD 54. suunisele ökotoksilisuse andmete statistilise analüüsi kehtivate meetodite kohta:
English: Mineralisation was negligible over the period of 100 days and non-extractable residues were formed during the incubation period and accounted for 26.5% of the applied radioactivity on day 45.
Estonian: 100 päeva järel oli mineralisatsioon tühine ning inkubatsiooniperioodil tekkisid eraldamatud jäägid, mis moodustasid 45. päeval manustatud radioaktiivsuse jääkidest 26,5%.
English: Ireland Ceva Sante Animale 10, avenue de La
Estonian: Prantsusmaa Ceva Sante Animale 10 Avenue de la
English: 831 02 Bratislava Slovak Republic
Estonian: 831 02 Bratislava
English: Results show that the dissipation time (DT50) of altrenogest in manure was 6.0 days (20±2 °C).
Estonian: Tulemused näitavad, et altrenogesti lagunemisaeg (DT50) sõnnikus oli 6 päeva (20±2 °C).
English: The aerobic transformation of altrenogest was investigated in four different soils (OECD Test Guideline 3074 (21.1 ± 0.1 °C for 21 days)).
Estonian: Altrenogesti aeroobset lagunemist hinnati neljas erinevas pinnases (OECD katsesuunis 3074 (21,1 ± 0,1 °C, 21 päeva)).
English: Yet, the results from the fish study indicate a potential environmental risk due to the endocrine disrupting properties of the substance below 0.4 µg/l.
Estonian: Kalade uuringu tulemused näitavad siiski võimalikku keskkonnariski seoses toimeaine sisesekretsioonisüsteemi kahjustava toimega kontsentratsioonis alla 0.4 µg/l.
English: These results are considered to be in line with existing literature data for progestagens and also with residue concentrations found in liver and kidney of pigs.
Estonian: Need tulemused on kooskõlas olemasolevate kirjandusandmetega progestageenide kohta ning sigade maksas ja neerudes tuvastatud jääkkontsentratsioonidega.
English: Following normalisation from the 21.1 °C study temperature to standard 20°C laboratory conditions using the Arrhenius equation (equivalent to a correction factor of 1.11), the DT50 proposed for use in modelling is 6.5 days.
Estonian: Pärast uuringutemperatuuri 21,1 °C normaliseerimist standardsetele 20 °C laboritingimustele Arrheniuse valemiga (vastab paranduskoefitsiendile 1,11) saadi soovituslik mudelis kasutatud DT50 6,5 päeva.
English: Rua Doutor António Loureiro Borges, nº 9/9A, 9ºA Miraflores - 1495-131 Algés
Estonian: Rua Doutor António Loureiro Borges, nº 9/9A, 9ºA
English: Germany CEVA Tiergesundheit GmbH
Estonian: CEVA Tiergesundheit GmbH
English: A fish life cycle test with zebrafish (Danio rerio), covering a complete fish generation (parental) and also part of the filial generation, was conducted to investigate the effects of a continuous exposure of altrenogest on different life stages, (including early life, juvenile growth, and reproduction stages of the parental generation, and early life stages of the filial generation).
Estonian: Tehti kala elutsükli test vöötdaanioga (Danio rerio), mis hõlmas kogu kalageneratsiooni (vanemorganismid) ning samuti osa järglaspõlvkonnast, et uurida altrenogesti pideva kokkupuute mõju eri eluperioodidel (sh vanemgeneratsiooni varane eluetapp, juveniilne kasvuetapp ja reproduktsiooniaeg ning järglaspõlvkonna varased eluetapid).
English: However, the CVMP considered that the assumption of 60% of the total dose being excreted via urine as an overly conservative value.
Estonian: Veterinaarravimite komitee arvates oli väide, et uriiniga eritub 60% koguannusest, liiga konservatiivne.
English: However, it is for the treatment of individual mares, i.e. not for the treatment of the entire herd for the synchronisation of ovulation.
Estonian: Ravimid on siiski näidustatud individuaalsete märade ravimiseks, mitte kogu karja samaaegseks raviks, et sünkroniseerida ovulatsiooni.
English: The anaerobic and aerobic degradation of altrenogest were investigated for altrenogest in manure and soil, respectively.
Estonian: Altrenogesti anaeroobset ja aeroobset lagunemist hinnati vastavalt sõnnikus ja pinnases.
English: However, the RQs calculated for the R3 scenario were above the threshold, i.e. 1.67 (1 m), >1.36 (3 m), >1.24 (5 m), and >1.04 (10 m), thus, indicating a risk for the aquatic environment for this scenario.
Estonian: R3 stsenaariumi jaoks arvutatud riskikoefitsiendid olid aga üle piirnormi, st 1,67 (1 m), >1,36 (3 m), >1,24 (5 m) ja >1,04 (10 m), viidates selle stsenaariumi korral veekeskkonnaohule.
English: Ceva Santé Animale B.V. Tiendweg 8c - 2671 SB Naaldwijk
Estonian: Tiendweg 8c - 2671 SB Naaldwijk
English: Consequently, based on metabolism studies the Committee concluded that the PECsoil can be more realistically refined considering the total excretion altrenogest-equivalents being 5% to 16.5% of the dose.
Estonian: Metabolismiuuringutele tuginedes järeldas komitee, et PECpinnas väärtust võib korrigeerida tegelikkusele vastavamaks, arvestades, et altrenogesti ekvivalentide kogueritus on 5%-16,5% annusest.
English: It is included in veterinary medicinal products currently authorised in the European Union for gilts and mares for zootechnical purposes (oestrus synchronisation).
Estonian: See toimeaine sisaldub veterinaarravimites, mis on praegu Euroopa Liidus heaks kiidetud kasutamiseks nooremistel ja märadel zootehnilistel eesmärkidel (inna sünkroniseerimine).
English: The MAHs make reference to the Council Directive 91/676/EEC concerning the protection of waters against pollution caused by nitrates from agricultural sources, which requires minimum distances to surface water which must be maintained when manure (or organic fertilizer) is spread onto cropland.
Estonian: Müügiloa hoidjad viitavad nõukogu direktiivile 91/676/EMÜ veekogude kaitsmise kohta põllumajandusest lähtuva nitraadireostuse eest, mis näeb ette minimaalse kauguse pinnaveest, millest tuleb kinni pidada, kui sõnnikut (või orgaanilist väetist) viljapõllule laotatakse.
English: Germany expressed concerns that veterinary medicinal products containing altrenogest may present a potential serious risk for the environment as the active substance is a steroid hormone and data from publicly available literature show a high risk to aquatic organisms arising from other steroids with a similar molecular structure.
Estonian: Saksamaa väljendas muret, et altrenogesti sisaldavad veterinaarravimid võivad põhjustada suurt keskkonnariski, sest toimeaine on steroidhormoon ja avaldatud kirjandusandmete järgi tekitavad sarnase molekulstruktuuriga steroidid veeorganismidele suure riski.
English: Laboratorios Intervet S.A. Polig.
Estonian: Laboratorios Intervet S.A.
English: The CVMP notes that veterinary medicinal products containing altrenogest are also authorised for use in mares.
Estonian: Veterinaarravimite komitee juhib tähelepanu sellele, et altrenogesti sisaldavad veterinaarravimid on heaks kiidetud kasutamiseks ka märadel.
English: These buffer zones are minimum distances to surface water which must be maintained when manure (or organic fertilizer) is spread onto cropland.
Estonian: Need puhvertsoonid on minimaalne kaugus pinnaveest, millest tuleb kinni pidada, kui sõnnikut (või orgaanilist väetist) viljapõldudele laotatakse.
English: Based on a PNEC <40 pg/l as well as the PECsurfacewater values from the scenarios above (release factor: 0.31, application rate of 0.094 g/ha) a risk was identified in STEP 4 for the R3 scenario (buffer zone 1-10 m), with risk quotients (RQs) of 3.29 (1 m), 2.84 (3 m), 2.59 (5 m), and 2.18 (10 m).
Estonian: Tuginedes ülaltoodud stsenaariumidest tuletatud PNEC väärtusele <40 pg/l ja samuti PECpinnavesi väärtustele (eraldumismäär 0.31, laotusmäär 0,094 g/ha), tuvastati risk stsenaariumi R3 etapis 4 (puhvertsoon 1-10 m), kusjuures riskikoefitsiendid olid 3,29 (1 m), 2,84 (3 m), 2,59 (5 m) ja 2,18 (10 m).
English: Ecotoxicity data
Estonian: Ökotoksilisus
English: From the Fish Full Life Cycle no NOEC can be derived since significant population relevant effects have been shown already in the lowest concentration tested, i.e. 400 pg/l altrenogest (effects on fertilisation and F1 survival being the most sensitive developmental stages).
Estonian: Kala täiselutsükli testist ei saanud tuletada täheldatavat toimet mitteavaldavat sisaldust, sest asjakohase populatsiooni jaoks olulisi toimeid täheldati juba madalaimal testitud kontsentratsioonil, st 400 pg/l altrenogesti (mõju viljastamisele ja F1 elulemusele olid kõige tundlikumad arenguetapid).
English: Metabolism data
Estonian: Metabolism
English: Based on this more realistic approach, and considering metabolism of up to 85% (release factor 0.15), no risk could be identified for R1 and R4 scenarios (in line with the MAHs calculation considering 69% metabolism, release factor 0.31).
Estonian: Realistlikumale lähenemisviisile tuginedes ja pidades silmas kuni 85% metabolismi (eraldumistegur 0,15), ei tuvastatud R1 ja R4 stsenaariumidega seoses riski (kooskõlas müügiloa hoidjate arvutustega, milles võeti arvesse 69% metabolismi ja eraldumistegurit 0,31).
English: Ceva Animal Health Slovakia, s. r. o.
Estonian: Tšehhi Vabariik Ceva Animal Health Slovakia, s. r. o.
English: The PECsoil initial was further refined using the results from the anaerobic transformation study of altrengest in pig manure which determined that 26.5% accounted for non-extractable residues at day 45, and could be considered potentially bioavailable altrenogest or conjugates of altrenogest.
Estonian: Algset PECpinnasväärtust täpsustati veelgi, kasutades sigade sõnnikus altrenogesti anaeroobse lagunemise uuringu tulemusi, mis näitasid, et 45. päeval oli 26,5% eraldamatuid jääke, mida võis pidada biosaadavaks altrenogestiks või selle konjugaatideks.
English: To determine PECsurfacewater, the FOCUS STEP 4 approach is the highest tier exposure scenario, in which all relevant and representative R scenarios (R1, R3 and R4) were considered by the CVMP.
Estonian: PECpinnavesi määramiseks kasutati kõrgeima taseme kokkupuutestsenaariumi FOCUS etapp 4, milles veterinaarravimite komitee võttis arvesse kõiki olulisi ja representatiivseid R stsenaariume (R1, R3 ja R4).
English: • the CVMP considered that at present in the EU there is no alternative available for oestrus synchronisation of gilts;
Estonian: • veterinaarravimite komitee leidis, et praegu ei ole ELis nooremiste inna sünkroniseerimiseks alternatiivset ravimit;
English: No NOEC (No-Observed Effect Concentration) could be derived (NOEC <0.4 ng/l) for altrenogest from the study, especially as analytical limitations proved difficult any further decrease in test concentrations.
Estonian: Uuringus ei olnud võimalik määrata altrenogesti täheldatavat toimet mitteavaldavat kontsentratsiooni (NOEC <0,4 ng/l), sest analüütilised piirangud raskendasid katsekontsentratsioonide vähendamist.
English: The environmental risk assessment is focused on the risk to the environment as a result of the zootechnical use of veterinary medicinal products containing altrenogest in gilts.
Estonian: Keskkonnariski hindamine keskendub nooremistele manustatavate altrenogesti sisaldavate veterinaarravimite zootehnilisest kasutamisest tulenevale keskkonnariskile.
English: Based on the available data, the marketing authorisation holders (MAHs) considered a worst-case scenario of renal elimination of altrenogest as the major route of excretion with 60% of the total dose of altrenogest being excreted in urine as altrenogest or altrenogest conjugates, and a total amount of 31% altrenogest-equivalents being excreted (considering complete deconjugation).
Estonian: Olemasolevatele andmetele tuginedes eeldasid müügiloa hoidjad, et halvima stsenaariumi korral eritub põhiliselt neerude kaudu väljutatava altrenogesti koguannusest 60% uriiniga altrenogesti või selle konjugaatidena ning kokku eritub 31% altrenogesti ekvivalentidest (täielik dekonjugatsioon).