FrancophonIA/ELRC3.0 huggingface dataset:
English: Clofarabine is one of a family of medicines called anticancer medicines.
Croatian: Klofarabin pripada skupini lijekova pod nazivom lijekovi protiv raka.
English: Volume of distribution (steady state)
Croatian: Distribucija: Volumen distribucije (stanje dinamičke ravnoteže)
English: Ask your doctor to explain what can be done to protect you or allow you to have a family.
Croatian: Pitajte liječnika kako se možete zaštititi i što možete učiniti kako biste zasnovali obitelj.
English: Tell your doctor if you are on a controlled sodium diet as it could affect how you will be given your medicine.
Croatian: Recite liječniku ako ste na režimu prehrane s ograničenim unosom natrija jer to može utjecati na način na koji će lijek biti primijenjen.
English: 125.3 to 130.0
Croatian: 125,3 do 130,0
English: CR = Complete remission
Croatian: KR = kompletna remisija
English: The 12 patients who achieved an overall remission (CR + CRp) had a median survival time of 66.6 weeks as of the data collection cut-off date.
Croatian: U 12 bolesnika u kojih je postignuta kompletna remisija (KR + KRt) medijan vremena preživljenja bio je 66,6 tjedana od zadnjeg dana za prikupljanje podataka.
English: This means that because of the rarity of this disease it has been impossible to get complete information on the reference medicine.
Croatian: To znači da zbog male učestalosti ove bolesti nije bilo moguće dobiti potpune informacije o referentnom lijeku.
English: • Recovery of peripheral counts (platelets ≥ 100 x 109/l and ANC ≥ 1.0 x 109/l)
Croatian: • oporavak broja perifernih stanica (trombociti ≥ 100 x 109/l i ABN ≥ 1,0 x 109/l)
English: Clofarabine should not be used during pregnancy unless clearly necessary.
Croatian: Klofarabin se ne smije primjenjivati tijekom trudnoće, osim ako je to neophodno.
English: In addition, at initiation of treatment, most patients in the clinical studies had haematological impairment as a manifestation of leukaemia.
Croatian: Uz to, u kliničkim je ispitivanjima većina bolesnika na početku liječenja imala hematološke poremećaje kao manifestaciju leukemije.
English: During treatment with Ivozall, your doctor will carry out regular blood tests and other tests to monitor your health.
Croatian: Tijekom liječenja lijekom Ivozall liječnik će redovito provoditi krvne i druge pretrage radi praćenja Vašeg zdravstvenog stanja.
English: Women who are able to get pregnant: you must use effective contraception during treatment with clofarabine.
Croatian: Žene koje mogu zatrudnjeti: morate primjenjivati učinkovitu kontracepciju tijekom liječenja klofarabinom.
English: 75.4 to 124.8
Croatian: 75,4 do 124,8
English: However, the final dilution volume may vary depending on the patient's clinical status and physician discretion.
Croatian: Međutim, konačni volumen razrijeđenog lijeka može se razlikovati ovisno o bolesnikovu kliničkom statusu i odluci liječnika.
English: Pharmacotherapeutic group: Antineoplastic agents, antimetabolites, purine analogues, ATC code: L01BB06.
Croatian: Farmakoterapijska skupina: Antineoplastici, antimetaboliti, analozi purina, ATK oznaka: L01BB06.
English: It is unknown whether clofarabine or its metabolites are excreted in human breast milk.
Croatian: Nije poznato izlučuju li se klofarabin ili njegovi metaboliti u majčino mlijeko u ljudi.
English: However, because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued prior to, during and following treatment with Ivozall (see section 4.3).
Croatian: Međutim, zbog mogućnosti javljanja ozbiljnih nuspojava u dojenčadi, dojenje se mora prekinuti prije, tijekom i nakon liječenja lijekom Ivozall (vidjeti dio 4.3).
English: • DNA polymerase α inhibition resulting in termination of DNA chain elongation and/or DNA synthesis / repair.
Croatian: • inhibiciji DNK polimeraze α, kojom se zaustavlja elongacija lanca DNK i/ili sinteza/popravak DNK
English: ORPHELIA Pharma 85 boulevard Saint-Michel 75005 PARIS France
Croatian: Pharma 85 boulevard Saint-Michel 75005 PARIS Francuska
English: Your treatment with Ivozall has been prescribed by a qualified doctor experienced in treating leukaemia.
Croatian: Liječenje lijekom Ivozall propisuje kvalificirani liječnik s iskustvom u liječenju leukemije.
English: Patients should be monitored for signs and symptoms of enterocolitis.
Croatian: Bolesnike je potrebno nadzirati za znakove i simptome enterokolitisa.
English: If you are breast-feeding, you must stop breast-feeding before starting the treatment, and must not breast-feed during your treatment and within 3 months after completion of your treatment.
Croatian: Ako dojite, morate prestati dojiti prije početka liječenja, a ne smijete dojiti tijekom liječenja i 3 mjeseca nakon završetka liječenja.
English: Studies in animals have shown reproductive toxicity including teratogenicity (see section 5.3).
Croatian: Istraživanja na životinjama ukazala su na reproduktivnu toksičnost, uključujući teratogenost (vidjeti dio 5.3).
English: Nearly all patients (98%) experienced at least one adverse event considered by the study investigator to be related to clofarabine.
Croatian: U gotovo svih bolesnika (98%) javio se barem jedan štetni događaj kojeg je ispitivač smatrao povezanim s klofarabinom.
English: There are no data on the use of clofarabine in pregnant women.
Croatian: Nema podataka o primjeni klofarabina u trudnica.
English: • An M1 bone marrow (≤ 5% blasts)
Croatian: • koštana srž M1 (≤ 5% blasta)
English: At this time, treatment may be reinitiated at the full dose.
Croatian: Nakon toga se liječenje može nastaviti uz primjenu pune doze.
English: • The use of prophylactic steroids (e.g., 100 mg/m2 hydrocortisone on Days 1 through 3) may be of benefit in preventing signs or symptoms of SIRS or capillary leak.
Croatian: • Profilaktička primjena steroida (npr. 100 mg/m2 hidrokortizona od 1. do 3. dana) može biti korisna za sprječavanje znakova ili simptoma SIRS-a ili povećane propusnosti kapilara.
English: Acute lymphoblastic leukaemia is caused by abnormal growth of some types of white blood cells.
Croatian: Akutnu limfoblastičnu leukemiju uzrokuje poremećen rast određenih vrsta bijelih krvnih stanica.
English: MARKETING AUTHORISATION NUMBER EU/1/19/1396/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/19/1396/001
English: Storage at low temperatures, i.e. below 15°C, might lead to formation of particles, which can be redissolved by letting the vial warm to room temperature and gentle swirling until all visible particles have dissolved.
Croatian: Čuvanje na niskim temperaturama, primjerice na temperaturama nižim od 15 °C može dovesti do stvaranja čestica koje se mogu ponovno otopiti tako da se bočica ugrije na sobnoj temperaturi i vrti nježnim kružnim pokretima dok se sve vidljive čestice ne otope.
English: Procedures for proper handling of antineoplastic agents should be observed.
Croatian: Potrebno je slijediti postupke za pravilno rukovanje antineoplasticima.
English: It will be given to you as an infusion through a long thin tube which goes into a vein (a drip), or into a small medical appliance that is inserted under the skin (port-a-cath) if you (or your child) have one implanted.
Croatian: Lijek će se primijeniti u obliku infuzije kroz dugačku tanku cjevčicu koja ulazi u venu (drip) ili u mali medicinski uređaj koji se umeće ispod kože (kateter „port-a-cath”) ako Vi (ili Vaše dijete) imate takav uređaj.
English: • Ribonucleotide reductase inhibition with reduction of cellular deoxynucleotide triphosphate (dNTP) pools.
Croatian: • inhibiciji ribonukleotid reduktaze uz smanjenje staničnih zaliha deoksinukleotid trifosfata (dNTP)
English: The incidence of these toxicities was dependent on both the dose of clofarabine administered and the duration of treatment.
Croatian: Incidencija navedenih toksičnosti ovisila je i o primijenjenoj dozi klofarabina i o trajanju liječenja.
English: Half-life of clofarabine triphosphate
Croatian: Poluvijek klofarabin trifosfata
English: Clear, practically colourless solution with a pH of 4.5 to 7.5 and an osmolarity of 270 to 310 mOsm/l, free from visible particles.
Croatian: Bistra, gotovo bezbojna otopina pH vrijednosti od 4,5 do 7,5 i osmolarnosti od 270 do 310 mOsm/l, bez vidljivih čestica.
English: The majority of patients who respond to clofarabine achieve a response after 1 or 2 treatment cycles (see section 5.1).
Croatian: Većina bolesnika s pozitivnim odgovorom na klofarabin postigne taj odgovor nakon 1 ili 2 ciklusa liječenja (vidjeti dio 5.1).
English: Therefore, it is unlikely to interact with active substances which inhibit or induce cytochrome P450 enzymes.
Croatian: Stoga nije vjerojatno da će ulaziti u interakcije s djelatnim tvarima koje inhibiraju ili induciraju enzime citokroma P450.
English: The median age of treated patients (37 males, 24 females) was 12 years old.
Croatian: Medijan dobi liječenih bolesnika (37 dječaka, 24 djevojčice) bio je
English: The minimal effects seen at lower doses suggest that there is a threshold for toxicities on the heart and nonlinear plasma pharmacokinetics in the rat may play a role in the observed effects.
Croatian: Minimalni učinci primijećeni kod nižih doza ukazuju na to da postoji prag toksičnosti za srce te da nelinearna farmakokinetika u plazmi u štakora može igrati ulogu u tim učincima.
English: Administration of clofarabine resulted in a dramatic and rapid reduction in peripheral leukaemia cells in 31 of the 33 patients (94%) who had a measurable absolute blast count at baseline.
Croatian: Primjena klofarabina dovela je do dramatičnog i brzog smanjenja broja perifernih leukemijskih stanica u 31 od 33 bolesnika (94%) koji su na početku liječenja imali mjerljiv ukupan broj blasta.
English: It was also active against quiescent lymphocytes and macrophages.
Croatian: Također je pokazao aktivnost i protiv neaktivnih limfocita i makrofaga.
English: 1.45 to 2.40
Croatian: 1,45 do 2,40
English: What you need to know before you use Ivozall
Croatian: Što morate znati prije nego počnete primjenjivati lijek Ivozall
English: Dose related toxicities on male reproductive organs were observed in mice, rats and dogs.
Croatian: Toksični učinci na muške reproduktivne organe povezani s dozom primijećeni su u miševa, štakora i pasa.
English: Safety and efficacy have been assessed in studies of patients ≤ 21 years old at initial diagnosis (see section 5.1).
Croatian: Sigurnost i djelotvornost su ocijenjene u ispitivanjima s bolesnicima koji su u trenutku početne dijagnoze imali ≤ 21 godine (vidjeti dio 5.1).
English: Ivozall is for single use only.
Croatian: Ivozall je namijenjen samo za jednokratnu primjenu.
English: Plasma protein binding Serum albumin Elimination: β half-life of clofarabine
Croatian: Vezanje za proteine u plazmi Albumin u serumu Eliminacija: β poluvijek klofarabina
English: If the ANC does not recover by 6 weeks from the start of a treatment cycle, a bone marrow aspirate / biopsy should be performed to determine possible refractory disease.
Croatian: Ako se apsolutan broj neutrofila (ABN) ne oporavi u roku od 6 tjedana od početka ciklusa liječenja, treba učiniti aspiraciju/biopsiju koštane srži radi utvrđivanja moguće refraktorne bolesti.
English: Immediate discontinuation of therapy, careful observation and initiation of appropriate supportive measures are recommended.
Croatian: Preporučuje se odmah obustaviti liječenje, pažljivo motriti bolesnika i primijeniti odgovarajuće potporne mjere.
English: Overall Survival (weeks)
Croatian: Ukupno preživljenje (tjedni)
English: However, as clofarabine is not detectably metabolised by the cytochrome P450 (CYP) enzyme system, pathways of non-renal elimination currently remain unknown.
Croatian: Međutim, budući da nije primijećen metabolizam klofarabina u kojem bi posredovao enzimski sustav citokroma P450 (CYP), putevi nebubrežne eliminacije ostaju nepoznati.
English: Before Ivozall is given to you, it will be diluted in a sodium chloride solution (salt and water).
Croatian: Ivozall će se prije primjene razrijediti u otopini natrijevog klorida (sol i voda).
English: Prophylactic anti-emetic medicinal products should be considered.
Croatian: Treba razmotriti primjenu profilaktičkih antiemetika.
English: There are no data on the pharmacokinetics, safety or efficacy of clofarabine in infants.
Croatian: Nema podataka o farmakokinetici, sigurnosti ni djelotvornosti klofarabina u dojenčadi.
English: If you think that you have missed a dose, tell your doctor straight away.
Croatian: Ako mislite da ste propustili dozu, odmah se obratite svom liječniku.
English: However, the majority of these hypotensive events were reported in patients who had confounding severe infections.
Croatian: Ipak, hipotenzija je u većini slučajeva bila prijavljena u bolesnika u kojih su postojale popratne teške infekcije.
English: Patients who did not undergo transplant
Croatian: Bolesnici koji nisu transplantirani KR
English: No apparent difference in pharmacokinetics was observed between patients with ALL or AML, or between males and females.
Croatian: Nije primijećena vidljiva razlika u farmakokinetici između bolesnika s ALL-om ili AML-om, kao ni između bolesnika muškog i ženskog spola.
English: Before enrolling in the trial, 58 of the 61 patients (95%) had received 2 to 4 different induction regimens and 18/61 (30%) of these patients had undergone at least 1 prior haematological stem cell transplant (HSCT).
Croatian: Prije uključivanja u ispitivanje 58 od 61 bolesnika (95%) primalo je 2 do 4 različita uvodna režima liječenja, a 18/61 (30%) od tih bolesnika bilo je prethodno podvrgnuto barem jednoj transplantaciji krvotvornih matičnih stanica (TKMS).
English: Common: Tumour lysis syndrome*
Croatian: često: sindrom lize tumora*
English: Patients receiving clofarabine may experience vomiting and diarrhoea; they should, therefore, be advised regarding appropriate measures to avoid dehydration.
Croatian: U bolesnika koji primaju klofarabin može doći do povraćanja i proljeva; stoga ih treba savjetovati o odgovarajućim mjerama za izbjegavanje dehidracije.
English: Patients who underwent transplant after alternative therapy or relapse*
Croatian: Bolesnici koji su transplantirani nakon zamjenskog liječenja ili relapsa bolesti*
English: Median time to progression (weeks)** (95% CI)
Croatian: Medijan vremena do progresije (tjedni)** (95% CI)
English: However, these data indicate that clofarabine may accumulate in such patients (see figure below).
Croatian: Međutim, ti podaci ukazuju na mogućnost akumulacije klofarabina u takvih bolesnika (vidjeti sliku u nastavku).
English: Driving and using machines Do not drive or use any tools or machines if you feel dizzy, light-headed or faint.
Croatian: Nemojte upravljati vozilima ni rukovati alatima i strojevima ako osjećate omaglicu, ošamućenost ili nesvjesticu.
English: To date, there are limited data on the pharmacokinetics of clofarabine in paediatric patients with decreased creatinine clearance.
Croatian: Trenutno postoje ograničeni podaci o farmakokinetici klofarabina u pedijatrijskih bolesnika sa smanjenim klirensom kreatinina.
English: What Ivozall contains
Croatian: Što Ivozall sadrži
English: Further treatment with clofarabine, generally at a lower dose, can be considered when patients are stabilised and organ function has returned to baseline.
Croatian: Daljnje liječenje klofarabinom, u pravilu uz primjenu niže doze, može se razmotriti kada se stanje bolesnika stabilizira, a funkcija organa vrati na početne vrijednosti.
English: However, the pericardial effusion was clinically significant in 2 patients with some associated haemodynamic compromise.
Croatian: Međutim, perikardni izljev bio je klinički značajan u 2 bolesnika s pridruženim poremećajem hemodinamike.
English: These infections may lead to septic shock, respiratory failure, renal failure, and/or multi-organ failure.
Croatian: Te infekcije mogu dovesti do septičkog šoka, zatajenja disanja, zatajenja bubrega i/ili višestrukog zatajenja organa.
English: (9.1 to 42)
Croatian: (9,1 do 42)
English: 2.41 to 2.50
Croatian: 2,41 do 2,50
English: See the section ‘Pregnancy and breast-feeding' below.
Croatian: Pogledajte dio „Trudnoća i dojenje‟ u nastavku teksta.
English: Females of childbearing potential and sexually active males must use effective methods of contraception during treatment.
Croatian: Žene reproduktivne dobi i seksualno aktivni muškarci moraju tijekom liječenja koristiti učinkovite metode kontracepcije.
English: Patients should be monitored for signs and symptoms of infection and treated promptly.
Croatian: Bolesnike treba nadzirati kako bi se uočili znakovi i simptomi infekcije i odmah ih liječiti.
English: The majority of the cases were associated with thrombocytopaenia (see section 4.8).
Croatian: Većina slučajeva bila je povezana s trombocitopenijom (vidjeti dio 4.8).
English: (4.6 to 38.3)
Croatian: (4,6 do 38,3)
English: The most frequent haematological laboratory abnormalities observed in patients treated with clofarabine were anaemia (83.3%; 95/114); leucopaenia (87.7%; 100/114); lymphopaenia (82.3%; 93/113), neutropaenia (63.7%; 72/113), and thrombocytopaenia (80.7%; 92/114).The majority of these events were of grade ≥ 3.
Croatian: Najčešći hematološki poremećaji u laboratorijskim nalazima primijećeni u bolesnika liječenih klofarabinom bili su anemija (83,3%; 95/114); leukopenija (87,7%; 100/114); limfopenija (82,3%; 93/113), neutropenija (63,7%; 72/113) i trombocitopenija (80,7%; 92/114).
English: Cytotoxic medicinal products should be handled with caution.
Croatian: Citotoksičnim lijekovima treba rukovati uz oprez.
English: Where follow-up data are available, the majority of bilirubin elevations returned to ≤ grade 2
Croatian: U slučajevima gdje postoje podaci o praćenju, povišena vrijednost bilirubina većinom se vratila na stupanj ≤ 2 u roku od 10 dana.
English: For instructions on dilution of the medicinal product before administration (see section 6.6).
Croatian: Za uputu o razrjeđivanju lijeka prije primjene (vidjeti dio 6.6).
English: However, patients should be advised that they may experience undesirable effects such as dizziness, light-headedness or fainting spells during treatment and told not to drive or operate machines in such circumstances.
Croatian: Međutim, bolesnike treba upozoriti da tijekom liječenja mogu doživjeti nuspojave poput omaglice, ošamućenosti ili nesvjestice i da u takvim okolnostima ne smiju upravljati vozilima ni rukovati strojevima.
English: Toxicology studies of clofarabine in mice, rats and dogs showed that rapidly proliferating tissues were the primary target organs of toxicity.
Croatian: Toksikološka istraživanja na miševima, štakorima i psima pokazala su da su primarni ciljni organi za toksični učinak klofarabina tkiva koja brzo proliferiraju.
English: • Disruption of mitochondrial membrane integrity with the release of cytochrome C and other proapoptotic factors leading to programmed cell death even in non-dividing lymphocytes.
Croatian: • oštećenju mitohondrijske membrane uz otpuštanje citokroma C i drugih proapoptotičnih faktora koji dovode do programirane smrti stanice čak i kod limfocita koji se ne dijele
English: • No evidence of circulating blasts or extramedullary disease
Croatian: • nema znakova blasta u krvotoku niti znakova ekstramedularne bolesti
English: Because of the pre-existing immuno-compromised condition of these patients and prolonged neutropaenia that can result from treatment with clofarabine, patients are at increased risk for severe opportunistic infections, including severe sepsis, with potentially fatal outcomes.
Croatian: Zbog prethodno oslabljenog imuniteta i dugotrajne neutropenije koja može biti posljedica liječenja klofarabinom, u tih bolesnika postoji povećan rizik od teških oportunističkih infekcija, uključujući i tešku sepsu, koja može imati smrtni ishod.
English: They were reported at exposure levels (Cmax) approximately 7 to 13 fold (after 3 or more dosing cycles) or 16 to 35 fold (after one or more dosing cycles) higher than clinical exposures.
Croatian: Toksičnosti su prijavljene kod razina izloženosti (Cmax) približno 7 do 13 puta većih (nakon 3 ili više ciklusa doziranja) odnosno 16 do 35 puta većih (nakon jednog ili više ciklusa doziranja) od kliničke izloženosti.
English: Adults (> 21 and < 65 years old)
Croatian: Posebne populacije bolesnika: Odrasli (u dobi > 21 i < 65 godina)
English: The threshold for developmental toxicity was considered to be 6 mg/m2/day in rats and 1.2 mg/m2/day in rabbits.
Croatian: Smatra se da je prag za razvojnu toksičnost bio 6 mg/m2 na dan u štakora i 1,2 mg/m2 na dan u kunića.
English: Most patients received conditioning regimens that included busulfan, melphalan, and/or the combination of cyclophosphamide and total body irradiation.
Croatian: Većina bolesnika primila je pripremnu terapiju koja je uključivala busulfan, melfalan i/ili kombinaciju ciklofosfamida i zračenja cijelog tijela.
English: In addition, clofarabine treatment should be discontinued if the patient develops hypotension for any reason during the 5 days of administration.
Croatian: Osim toga, liječenje klofarabinom se mora prekinuti ako se u bolesnika tijekom petodnevne primjene lijeka iz bilo kojeg razloga pojavi hipotenzija.
English: If you forget to use Ivozall
Croatian: Ako ste zaboravili primijeniti lijek Ivozall
English: Therefore, a safe and effective dosage recommendation for patients < 1 year old has yet to be established.
Croatian: Stoga u tih bolesnika u dobi < 1 godine tek treba ustanoviti sigurnu i djelotvornu preporučenu dozu.
English: • Renal and hepatic function prior to, during active treatment and following therapy.
Croatian: • bubrežnu i jetrenu funkciju prije, tijekom davanja lijeka i nakon liječenja.
English: **Patients alive and in remission at the time of last follow up were censored at that time point for the analysis.
Croatian: ** podaci o bolesnicima koji su u vrijeme posljednje procjene bili živi i u remisiji u analizi su cenzurirani
English: Clofarabine must be discontinued for exfoliative or bullous rash, or if SJS or TEN is suspected.
Croatian: Klofarabin se mora prestati uzimati kod eksfolijativnog ili buloznog osipa ili ako se sumnja u SJS ili TEN.
English: Treatment cycles should be repeated every 2 to 6 weeks (from the starting day of the previous cycle) following recovery of normal haematopoiesis (i.e. ANC ≥ 0.75 × 109/l) and return to baseline organ function.
Croatian: Cikluse liječenja treba ponavljati svakih 2 do 6 tjedana (od prvog dana prethodnog ciklusa) nakon ponovne uspostave normalne hematopoeze (tj. ABN ≥ 0,75 × 109/l)
English: Cardiac effects were observed in rats consistent with cardiomyopathy and contributed to signs of cardiac failure after repeated cycles of treatment.
Croatian: U štakora su primijećeni učinci na srce koji su odgovarali kardiomiopatiji, a pridonijeli su znakovima zatajenja srca nakon višekratnih ciklusa liječenja.
English: In addition, clofarabine is unlikely to inhibit any of the major 5 human CYP isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) or to induce 2 of these isoforms (1A2 and 3A4) at the plasma concentrations achieved following intravenous infusion of 52 mg/m2/day.
Croatian: Osim toga, nije vjerojatno da bi klofarabin mogao inhibirati neki od 5 glavnih izoformi CYP u ljudi (1A2, 2C9, 2C19, 2D6 i 3A4) ni inducirati dvije od navedenih izoformi (1A2 i 3A4) pri koncentracijama u plazmi koje se postižu nakon intravenske infuzije doze od 52 mg/m2 na dan.
English: Therapy must be initiated and supervised by a physician experienced in the management of patients with acute leukaemias.
Croatian: Liječenje mora započeti i nadzirati liječnik s iskustvom u liječenju bolesnika s akutnim leukemijama.
English: If you are the parent of a child who is being treated with Ivozall, tell the doctor if any of the above conditions apply to your child.
Croatian: Ako ste roditelj djeteta koje se liječi lijekom Ivozall, obavijestite liječnika ako se bilo što od gore navedenog odnosi na Vaše dijete.
English: As the effect of clofarabine treatment on human fertility is unknown, reproductive planning should be discussed with patients as appropriate.
Croatian: Budući da je učinak klofarabina na plodnost u ljudi nepoznat, s bolesnicima po potrebi treba razgovarati o planiranju obitelji.