FrancophonIA/ELRC3.0 huggingface dataset:
English: Since there is a potential for an increase in the risk of dose-related adverse reactions, a decrease in rosiglitazone dose may be needed.
Slovenian: Ker obstaja možnost večjega tveganja za neželene reakcije, povezane z odmerkom, utegne biti potrebno zmanjšanje odmerka rosiglitazona.
English: The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2).
Slovenian: Glavna presnovka sta cikloheksilhidroksimetil-derivat (M1) in karboksil-derivat (M2).
English: Opaque blisters (PVC/PVDC/aluminium).
Slovenian: Neprosojni pretisni omoti (PVC/PVDC/aluminij).
English: The chances of this happening may be higher in people, particularly women, taking rosiglitazone for more than one year.
Slovenian: Verjetnost, da se to zgodi, je lahko večja pri tistih osebah, zlasti ženskah, ki jemljejo zdravilo Avaglim več kot eno leto.
English: Although the hydroxy metabolite of glimepiride caused a small but significant reduction in serum glucose, it accounts for only a minor part of the total drug effect.
Slovenian: Čeprav je hidroksi-presnovek glimepirida povzročil majhno, a pomembno znižanje glukoze v serumu, gre na račun tega le manjši del celotnega učinka zdravila.
English: Manufacturer: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero, Burgos,
Slovenian: Izdelovalec: Glaxo Wellcome S.A., Avenida de Extremadura 3, 09400 Aranda de Duero, Burgos,
English: The dose of the rosiglitazone component can be increased after 8 weeks if required.
Slovenian: Če je potrebno, je mogoče odmerek rosiglitazona po 8 tednih povečati.
English: Avaglim can cause reductions in some types of blood cells.
Slovenian: Avaglim lahko povzroči zmanjšanje števila neketerih vrst krvnih celic.
English: Rosiglitazone 4 mg should be administered concomitantly with the dose of sulphonylurea already being taken.
Slovenian: Rosiglitazon 4 mg je treba aplicirati sočasno z odmerkom že uporabljane sulfonilsečnine.
English: AVAGLIM therapy should be individualised for each patient.
Slovenian: Zdravljenje z AVAGLIMOM je treba prilagoditi vsakemu bolniku posamezno.
English: The protein binding of the major metabolite (a para-hydroxy-sulphate) is very high (> 99.99%).
Slovenian: Vezava glavnega presnovka (parahidroksisulfata) na beljakovine je zelo visoka (> 99,99 %).
English: As per the CHMP Guideline on Risk Management Systems for medicinal products for human use, any updated RMP should be submitted at the same time as the following Periodic Safety Update Report
Slovenian: V skladu s smernicami Odbora za zdravila za uporabo v humani medicini za sisteme za obvladovanje tveganja za zdravila za uporabo v humani medicini mora biti posodobljen načrt za obvladovanje tveganja predložen hkrati z naslednjim posodobljenim poročilom o varnosti zdravila (PSUR).
English: After intravenous dosing in normal subjects, the volume of distribution was 8.8 l (113 ml/kg), and the total body clearance was 47.8 ml/min.
Slovenian: Po intravenski uporabi pri zdravih preiskovancih je bil volumen porazdelitve 8,8 l (113 ml/kg), celotni telesni očistek pa 47,8 ml/min.
English: The antihyperglycaemic activity of rosiglitazone has been demonstrated in a number of animal models of type 2 diabetes.
Slovenian: Antihiperglikemično delovanje rosiglitazona je dokazano v številnih živalskih modelih diabetesa tipa 2.
English: Glimepiride is excreted into the milk of lactating rats.
Slovenian: Glimepirid se izloča v mleku doječih podgan.
English: An outcome study has not been completed with rosiglitazone, therefore the long-term benefits associated with improved glycaemic control have not been
Slovenian: Študij izida z rosiglitazonom ni bilo, zato dolgoročne koristi, povezane z boljšo urejenostjo glikemije, niso ugotovljene.
English: In studies with a maximal duration of three years, rosiglitazone given once or twice daily produced a sustained improvement in glycaemic control (FPG and HbA1c).
Slovenian: V študijah, ki so trajale največ tri leta, je rosiglitazon, uporabljen enkrat ali dvakrat na dan, povzročil dolgotrajno izboljšanje urejenosti glikemije (GPT in HbA1c).
English: Avaglim tablets come in different strengths.
Slovenian: Avaglim tablete so na voljo v različnih jakostih.
English: • allergic reactions, inflammation of blood vessels (allergic vasculitis)
Slovenian: • alergijske reakcije, vnetje krvnih žil (alergijski vaskulitis)
English: *The frequency category for the background incidence of this event, as taken from placebo group data from clinical trials, is 'common'.
Slovenian: Zelo pogosti *Kategorija pogostnosti glede na osnovno pojavnost tega dogodka, kot izhaja iz podatkov kliničnih preskušanj pri skupinah s placebom, je 'pogosti'.
English: Undesirable effects observed in animal studies with possible relevance to clinical use were as follows: An increase in plasma volume accompanied by decrease in red cell parameters and increase in heart weight.
Slovenian: Neželeni učinki, ugotovljeni v študijah na živalih, ki bi lahko bili pomembni za klinično uporabo, so: povečanje količine plazme, ki jo spremlja zmanjšanje parametrov eritrocitov in povečanje mase srca.
English: Although hormonal imbalance has been seen in preclinical studies (see section 5.3), no significant undesirable effects associated with menstrual disorders have been observed.
Slovenian: V predkliničnih študijah (glejte poglavje 5.3) so sicer opazili hormonsko neravnovesje, ne pa pomembnih neželenih učinkov, kar zadeva motnje menstruacije.
English: 7 Mild hypersensitivity reactions may develop into serious reactions with dyspnoea, fall in blood
Slovenian: 7 Blage preobčutljivostne reakcije se lahko razvijejo v resne reakcije z dispnejo, padcem krvnega tlaka in
English: After oral administration, glimepiride is completely (100%) absorbed from the gastrointestinal tract.
Slovenian: Po peroralni uporabi se glimepirid popolnoma (100 %) absorbira iz prebavil.
English: If hypoglycaemic symptoms occur, the patient should revert to concomitant therapy and adjust the glimepiride dose as appropriate.
Slovenian: Če se pojavijo simptomi hipoglikemije, se mora bolnik vrniti na sočasno terapijo in odmerek glimepirida je treba ustrezno prilagoditi.
English: • Avaglim is not recommended during pregnancy.
Slovenian: • Uporaba zdravila Avaglim med nosečnostjo ni priporočljiva.
English: 8 Based on what is known of other sulphonylureas, hypoglycaemia may be prolonged.
Slovenian: 8 Glede na to, kar je znanega o drugih sulfonilsečninah, so takšne hipoglikemije lahko dolgotrajne.
English: • shortness of breath, waking up short of breath at night
Slovenian: težko dihanje, prebujanje ponoči zaradi težkega dihanja.
English: Limited data with AVAGLIM is also consistent with this combined adverse reaction profile.
Slovenian: Tudi omejeni podatki o AVAGLIMU se skladajo s temi kombiniranimi značilnostmi neželenih učinkov.
English: • increased sensitivity to the sun causing skin rash
Slovenian: • povečana občutljivost na sončno svetlobo z kožnim izpuščajem
English: It may be used in non-insulin dependent diabetes mellitus.
Slovenian: Uporablja se lahko pri sladkorni bolezni, ki ni odvisna od insulina.
English: In reproductive toxicity studies, administration of rosiglitazone to rats during mid-late gestation was associated with foetal death and retarded foetal development.
Slovenian: V študijah reproduktivne toksičnosti je bila uporaba rosiglitazona pri podganah med srednjo-pozno gestacijo povezana s fetalnimi smrtmi in zapoznelim razvojem plodov.
English: Therefore, liver enzymes should be checked prior to the initiation of therapy with AVAGLIM in all patients and periodically thereafter based on clinical judgement.
Slovenian: Zato je treba pred uvedbo terapije z AVAGLIMOM jetrne encime preveriti pri vseh bolnikih, pozneje pa občasno na osnovi klinične presoje.
English: Increases in liver weight, plasma ALT (dog only) and fat tissue were also observed.
Slovenian: Opažali so tudi povečanje mase jeter, zvišanje ALT v plazmi (le pri psih) in porast maščobnega tkiva.
English: This was based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenicity, and fertility.
Slovenian: To je bilo ugotovljeno na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih, genotoksičnosti, kancerogenega potenciala in vpliva na sposobnost razmnoževanja.
English: In addition, rosiglitazone inhibited ovarian oestradiol and progesterone synthesis and lowered plasma levels of these hormones resulting in effects on oestrus/menstrual cycles and fertility (see section 4.4).
Slovenian: Poleg tega je rosiglitazon zavrl sintezo estradiola in progesterona v jajčnikih in znižal koncentracijo teh hormonov v plazmi, kar je vplivalo na estrus/menstruacijske cikluse in plodnost (glejte poglavje 4.4).
English: If risk factors for hypoglycaemia are present (including renal insufficiency, low body weight, malnourishment, co-administration with certain other medicinal products (see section 4.5) or if the patient's life-style changes) it may be necessary to revert to concomitant therapy and down titrate the glimepiride dose.
Slovenian: Če so prisotni dejavniki tveganja za hipoglikemijo (vključno z insuficienco ledvic, nizko telesno maso, nezadostno prehranjenostjo, sočasno uporabo določenih drugih zdravil (glejte poglavje 4.5) ali če se bolnikov način življenja spremeni) utegne biti potrebna vrnitev na sočasno terapijo in zmanjšanje odmerka glimepirida.
English: In an animal model for familial adenomatous polyposis (FAP), treatment with rosiglitazone at 200 times the pharmacologically active dose increased tumour multiplicity in the colon.
Slovenian: V živalskem modelu familiarne adenomatozne polipoze (FAP) je uporaba rosiglitazona v 200-kratniku farmakološko aktivnega odmerka povečala število tumorjev v kolonu.
English: • if you have had diabetic ketoacidosis (a complication of diabetes causing rapid weight
Slovenian: • če imate diabetično ketoacidozo (zaplet sladkorne bolezni s hitrim hujšanjem, siljenjem
English: The incidence of all adverse events relating to liver and biliary systems was < 1.5% in any treatment group and similar to placebo.
Slovenian: Incidenca vseh neželenih pojavov, povezanih s hepatobiliarnim sistemom, je bila v vseh zdravljenih skupinah < 1,5 % in podobna, kot pri placebu.
English: Studies on embryofoetal development and pre-and postnatal development revealed eye malformations, skeletal anomalies, abortions, and an increased foetal death rate.
Slovenian: Študije embriofetalnega razvoja ter pred- in ponatalnega razvoja so pokazale malformacije oči, anomalije okostja, splave in večjo umrljivost plodov.
English: There are no adequate data from the use of either active substance (rosiglitazone and glimepiride) in pregnant women.
Slovenian: Ni zadostnih podatkov o uporabi ene ali druge zdravilne učinkovine (rosiglitazona ali glimepirida) pri nosečnicah.
English: • if you are allergic (hypersensitive) to rosiglitazone, glimepiride, or any of the other ingredients of Avaglim (listed in Section 6), or to other medicines called sulphonylureas
Slovenian: • če ste alergični na (preobčutljivi za) rosiglitazon, glimepirid ali katerokoli drugo sestavino zdravila Avaglim (navedene v poglavju 6), ali na zdravila imenovana sulfonilsečnine (npr.
English: Like all medicines, Avaglim can cause side effects, but not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo Avaglim neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: Many medicines (or alcohol) can affect the way Avaglim controls the amount of sugar in your blood.
Slovenian: Nekatera zdravila (ali alkohol) lahko še posebej vplivajo na način kako zdravilo Avaglim uravnava vrednost krvnega sladkorja.
English: Very rare impairment of liver function (e.g. with cholestasis and jaundice)
Slovenian: Zelo redki okvara delovanja jeter (npr. s holestazo in zlatenico)
English: Based on the experience with glimepiride and with other sulphonylureas the following interactions
Slovenian: Na podlagi izkušenj z glimepiridom in drugimi sulfonilsečninami je treba omeniti naslednja medsebojna
English: This leads to a release of insulin by exocytosis.
Slovenian: To povzroči sprostitev insulina z eksocitozo.
English: • if you have had a heart attack or severe angina, that's being treated in hospital
Slovenian: • če ste doživeli srčni napad ali imate hudo angino pektoris in ste se zaradi tega zdravili v
English: • reduction in blood count (anaemia) low numbers of white blood cells (leucopaenia) and blood cells needed for blood clotting (thrombocytopaenia)
Slovenian: • zmanjšanje števila krvnih celic (anemija) nizke vrednosti belih krvničk (levkopenija) in krvnih celic potrebnih za strjevanje krvi (trombocitopenija)
English: AVAGLIM is not indicated for combination use with metformin and therefore should not be used in
Slovenian: AVAGLIM ni indiciran za kombinirano uporabo z metforminom, zato ga ne smete uporabljati v tritirni
English: (monotherapy or dual oral therapy).
Slovenian: (monoterapija ali peroralno zdravljenje z dvema zdravilnima učinkovinama).
English: The major routes of metabolism are N-demethylation and hydroxylation, followed by conjugation with sulphate and glucuronic acid.
Slovenian: Glavni poti presnove sta N-demetilacija in hidroksilacija, ki jima sledi konjugacija s sulfatom in glukuronsko kislino.
English: The contribution of the major metabolite (a para-hydroxy-sulphate) to the overall antihyperglycaemic activity of rosiglitazone has not been fully elucidated in man and it cannot be ruled out that the metabolite may contribute to the activity.
Slovenian: Prispevek glavnega presnovka (parahidroksisulfata) k celotnemu antihiperglikemičnemu delovanju rosiglitazona pri človeku ni povsem razjasnjen in ni mogoče izključiti, da ta presnovek pripomore k delovanju.
English: The following statements reflect the pharmacokinetic properties of the individual components of
Slovenian: Naslednje navedbe temeljijo na farmakokinetičnih lastnostih posameznih sestavin AVAGLIMA.
English: Hospitalisation should be considered as appropriate.
Slovenian: Zaradi tega je ustrezen ukrep hospitalizacija.
English: Since there is no significant in vitro inhibition of CYP1A2, 2A6, 2C19, 2D6, 2E1, 3A or 4A with rosiglitazone, there is a low probability of significant metabolism-based interactions with substances metabolised by these P450 enzymes.
Slovenian: Rosiglitazon in vitro ne zavira pomembno CYP1A2, 2A6, 2C19, 2D6, 2E1, 3A ali 4A, tako da obstaja le majhna verjetnost za pomembne presnovno pogojene interakcije s snovmi, ki se presnavljajo s temi encimi P450.
English: Administration of rosiglitazone with food resulted in no change in overall exposure (AUC), although a small decrease in Cmax (approximately 20-28%) and a delay in tmax (approximately 1.75 h) were observed compared to dosing in the fasted state.
Slovenian: Uporaba rosiglitazona s hrano ni spremenila celotne izpostavljenosti (AUC), zabeležili pa so majhno zmanjšanje Cmax (približno 20-28 %) in zapoznitev tmax (približno 1,75 ure) v primerjavi z uporabo na tešče.
English: Both rosiglitazone and glimepiride have been detected in the milk of experimental animals.
Slovenian: Tako rosiglitazon kot glimepirid so odkrili v mleku poskusnih živali.
English: AVAGLIM may be used to substitute concomitant sulphonylurea and rosiglitazone in established dual oral therapy providing the patient has achieved at least half-maximum dose of sulphonylurea.
Slovenian: AVAGLIM je mogoče uporabiti kot zamenjavo za sočasno uporabo sulfonilsečnine in rosiglitazona v utečeni dvotirni peroralni terapiji, če je bolnik dosegel vsaj polovični največji odmerek sulfonilsečnine.
English: The symptoms may be delayed for up to 24 hours after ingestion.
Slovenian: Simptomi se lahko pojavijo z zamikom do 24 ur po zaužitju.
English: The MAH commits to performing the studies and additional pharmacovigilance activities detailed in the Pharmacovigilance Plan, as agreed in version 4 of the Risk Management Plan (RMP) presented in Module 1.8.2. of the Marketing Authorisation and any subsequent updates of the RMP agreed by the
Slovenian: Imetnik dovoljenja za promet z zdravilom se obvezuje, da bo izvedel študije in dodatne farmakovigilančne aktivnosti, podrobno opisane v načrtu farmakovigilance, ki je bil sprejet v različici 4 načrta za obvladovanje tveganja (RMP), predstavljenem v modulu 1.8.2. vloge za pridobitev dovoljenja za promet z zdravilom in vseh nadaljnih posodobitvah načrta za obvladovanje tveganja v soglasju z Odborom za zdravila za uporabo v humani medicini (CHMP).
English: 6 Cross-allergenicity with sulphonylureas, sulphonamides or related substances is possible.
Slovenian: 6 Možna je navzkrižna preobčutljivost s sulfonilsečninami, sulfonamidi in sorodnimi učinkovinami.
English: Rare Rare Rare Rare Rare Rare Rare
Slovenian: Zelo redki Zelo redki Zelo redki Zelo redki Zelo redki Zelo redki
English: Women who are infertile due to a condition affecting their ovaries (such as Polycystic Ovarian Syndrome), may start ovulating again when they start taking Avaglim.
Slovenian: Pri ženskah, ki so zaradi bolezni jajčnikov (kot je sindrom policističnega jajčnika) neplodne, se lahko po začetku jemanja zdravila Avanglim ponovno pojavi ovulacija.
English: The other ingredients are: sodium starch glycollate (Type A), hypromellose (E464), microcrystalline cellulose (E460), lactose monohydrate, magnesium stearate, titanium dioxide (E171), macrogol 400,
Slovenian: Pomožne snovi so: natrijev karboksimetilškrob (vrsta A), hipromeloza (E464), mikrokristalna celuloza (E460), laktoza monohidrat, magnezijev stearat, titanov dioksid (E171), makrogol 400, črni in/ali rdeči
English: The following data are findings in studies performed with rosiglitazone or glimepiride individually.
Slovenian: Naslednji podatki so izsledki študij, narejenih z rosiglitazonom oz. glimepiridom posamezno.
English: In view of the potential for development of heart failure in these patients, rosiglitazone should therefore not be initiated in patients having an acute coronary event and it should be discontinued during the acute
Slovenian: Glede na možno tveganje za pojav srčnega popuščanja pri teh bolnikih, se zdravljenja z rosiglitazonom ne sme uvesti pri bolnikih, ki imajo akutni koronarni dogodek, oziroma je treba zdravljenje med akutno fazo
English: If ALT levels are increased to >3X upper limit of normal during rosiglitazone therapy, liver enzyme levels should be reassessed as soon as possible.
Slovenian: Če se raven ALT med zdravljenjem z rosiglitazonom zviša na > 3-kratno zgornjo normalno mejo, je treba čim prej znova določiti raven jetrnih encimov.
English: It reduces glycaemia by reducing insulin resistance at adipose tissue, skeletal muscle and liver.
Slovenian: Glikemijo znižuje z zmanjševanjem odpornosti za insulin v maščobnem tkivu, skeletnih mišicah in jetrih.
English: Concomitant administration of rosiglitazone with the oral anti-diabetic agents metformin, glimepiride, glibenclamide and acarbose did not result in any clinically relevant pharmacokinetic interactions.
Slovenian: Sočasna uporaba rosiglitazona s peroralnimi antidiabetičnimi zdravili metforminom, glimepiridom, glibenklamidom in akarbozo ni povzročila klinično pomembnih farmakokinetičnih interakcij.
English: All patients, particularly those receiving concurrent insulin therapy, those at risk for heart failure and those with reduced cardiac reserve, should be monitored for signs and symptoms of adverse reactions relating to fluid retention, including weight gain and heart failure.
Slovenian: Vse bolnike, še posebej pa bolnike, ki se sočasno zdravijo z insulinom, bolnike pri katerih obstaja tveganje srčnega popuščanja in bolnike z zmanjšano srčno rezervo, je treba nadzirati glede pojava znakov in simptomov neželenih učinkov, povezanih z zastajanjem tekočine, vključno s povečanjem telesne mase in srčnim popuščanjem.
English: WHAT AVAGLIM IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO AVAGLIM IN ZA KAJ GA UPORABLJAMO
English: For this reason, other medicines should only be taken with the knowledge (or at the prescription) of the doctor.
Slovenian: Zato smejo bolniki druga zdravila jemati le z zdravnikovo vednostjo ali po njegovem navodilu.
English: Glimepiride is metabolized by cytochrome P450 2C9 (CYP2C9).
Slovenian: Glimepirid se presnavlja s citokromom P450 2C9 (CYP2C9).
English: quinolone antibiotics, probenecid, miconazol, pentoxifylline (high dose parenteral), tritoqualine, fluconazole.
Slovenian: kinolonski antibiotiki, probenecid, mikonazol, pentoksifilin (velik parenteralen odmerek), tritokalin, flukonazol.
English: Very rare Very rare
Slovenian: Zelo redki Zelo redki
English: After intravenous dosing in patients, no significant biliary excretion of glimepiride or its M1 metabolite was observed.
Slovenian: Po intravenski uporabi pri bolnikih niso ugotovili pomembnega biliarnega izločanja glimepirida ali presnovka M1.
English: For AVAGLIM no preclinical or clinical data on exposed pregnancies or lactation are available.
Slovenian: Za AVAGLIM ni na voljo predkliničnih ali kliničnih podatkov o nosečnostih ali dojenju med
English: Preclinical effects were observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use or were caused by the pharmacodynamic effect (hypoglycaemia) of the substance.
Slovenian: Predklinično so učinke glimepirida opazili samo pri izpostavljenosti, ki je močno presegala največjo izpostavljenost pri človeku, kar kaže na majhen pomen za klinično uporabo, ali jih je povzročil njegov farmakodinamični učinek (hipoglikemija).
English: Patients unable to achieve glycaemic control on at least half-maximum dose of other sulphonylurea monotherapy (except chlorpropamide, see section 4.4).
Slovenian: Bolniki, ki ne morejo doseči urejenosti glikemije z vsaj polovico največjega odmerka druge sulfonilsečnine v monoterapiji (razen klorpropamida, glejte poglavje 4.4).
English: Avaglim and other medicines for diabetes can make some existing conditions worse, or cause serious side effects.
Slovenian: Zdravilo Avanglim in druga zdravila za zdravljenje sladkorne bolezni lahko poslabšajo nekatera že obstoječa bolezenska stanja ali povzročijo hude neželene učinke.
English: If any patient develops symptoms suggesting hepatic dysfunction, which may include unexplained nausea, vomiting, abdominal pain, fatigue, anorexia and/or dark urine, liver enzymes should be checked.
Slovenian: Če se pojavijo simptomi, ki nakazujejo moteno delovanje jeter - med takšnimi so lahko nepojasnjena navzeja, bruhanje, bolečine v trebuhu, utrujenost, anoreksija in/ali temen urin - je treba preveriti jetrne encime.
English: The physiological response to acute physical exercise, a reduction in insulin secretion, is maintained during treatment with glimepiride.
Slovenian: Zmanjšanje izločanja insulina, ki je fiziološki odziv na akutno telesno obremenitev, se med zdravljenjem z glimepiridom ohrani.
English: Plasma concentrations are approximately dose proportional over the therapeutic dose range.
Slovenian: V območju terapevtskih odmerkov je koncentracija v plazmi približno sorazmerna odmerku.
English: Therapy with AVAGLIM should not be initiated in patients with increased baseline liver enzyme levels (ALT >2.5X upper limit of normal) or with any other evidence of liver disease.
Slovenian: Terapije z AVAGLIMOM ne smete uvesti pri bolnikih, ki imajo izhodiščno zvišano raven jetrnih encimov (ALT > 2,5-kratna zgornja normalna meja) ali kakšne druge znake bolezni jeter.
English: Rosiglitazone is a selective agonist at the PPARγ (peroxisome proliferator activated receptor gamma) nuclear receptor and is a member of the thiazolidinedione class of antihyperglycaemic agents.
Slovenian: Rosiglitazon je selektiven agonist jedrnih receptorjev PPARγ (peroksisomski proliferatorski aktivirani receptor gama) in spada med tiazolidindionske antihiperglikemike.
English: • inflammation of the liver (hepatitis), yellowing of the skin (jaundice)
Slovenian: • vnetje jeter (hepatitis), rumeno obarvanje kože (zlatenica)