FrancophonIA/ELRC3.0 huggingface dataset:
English: Dosages of 180 mg/m2 four times daily in children produced similar systemic exposure (24 hour AUC 40.0 h μM or 10.7 h μg/ml) as doses of 200 mg six times daily in adults (40.7 h μM or 10.9 h μg/ml).
Maltese: h μM or 10.7 h μg/ml) f'dożi ta' 200 mg sitt darbiet kuljum fl-adulti (40.7 h μM jew 10.9 h μg/ml).
English: The M184V RT mutant shows a <4-fold decrease in susceptibility to didanosine; the clinical significance of these findings is unknown.
Maltese: Il-mutant M184V juri tnaqqis ta' <4 darbiet fis-suxxettibilta' tiegħu għal didanosine; l-importanza klinika ta' dawn ir-riżultati mhix magħrufa.
English: Cross-resistance conferred by the M184V RT is limited within the nucleoside inhibitor class of antiretroviral agents.
Maltese: Ir-reżistenza inkroċjata li jagħti l-M184V RT hi limitata fil-grupp tal-inibitur nukleosidi ta' prodotti antiretrovirali.
English: • pentamidine or atovaquone to treat parasitic infections such as Pneumocystis jirovecii pneumonia
Maltese: • pentamidine jew atovaquone, biex jikkura infezzjonijiet parassitiċi bħal pulmonite b'Pneumocystis jirovecii (ħafna drabi ssir referenza għaliha bħala PCP [Pneumocystis jirovecii pneumonia])
English: From studies with intravenous zidovudine, the mean terminal plasma half-life was 1.1 hours and the mean systemic clearance was 1.6 l/h/kg.
Maltese: Minn studji fuq zidovudine li ngħata minn ġol-vina il-half-life terminali fil-plażma medju kien ta' 1.1 sigħat u t-tneħħija sistemika medja kienet ta' 1.6 l/h/kg.
English: • phenytoin, for treating epilepsy.
Maltese: • phenytoin, biex jikkura l-epilessija.
English: Zidovudine AUC ↑106% (UGT inhibition)
Maltese: L-AUC ta' Zidovudine ↑106% (impediment ta' UGT)
English: Abbreviations: ↑ = Increase; ↓=decrease; ↔= no significant change; AUC=area under the concentration versus time curve; Cmax=maximum observed concentration; CL/F=apparent oral clearance
Maltese: Taqsiriet ↑ =Żieda; ↓=tnaqqis; ↔= l-ebda tibdil sinifikanti; AUC=l-erja taħt il-kurva tal-konċentrazzjoni mal-ħin; Cmax=l-ogħla konċentrazzjoni osservata;
English: • an increase in an enzyme called amylase
Maltese: • żieda f'enzima msejħa amylase.
English: Clinically significant interaction unlikely.
Maltese: Mhux probabbli li jkun hemm interazzjoni klinikament sinifikanti.
English: Methadone/Zidovudine (30 to 90 mg once daily/200 mg every 4 hours)
Maltese: Methadone/Zidovudine (30 sa 90 mg darba kuljum/200 mg darba kull
English: Additionally dosage adjustment of zidovudine may be required if severe anaemia or myelosuppression occurs during treatment with Lamivudine/Zidovudine Teva, or in patients with preexisting bone marrow compromise e.g. haemoglobin <9 g/dl (5.59 mmol/l) or neutrophil count <1.0 x 10
Maltese: Barra minn hekk aġġustament fid-doża ta' zidovudine tista' tkun meħtieġa jekk ikun hemm anemija severa jew majelosuppressjoni waqt il-kura b'Lamivudine/Zidovudine Teva, jew f'pazjenti li għandhom il-mudullun kompromess eż, emoglobina <9 g/dl (5.59 mmol/l) jew li għandhom l-għadd ta' newtrofili <1.0 x 109/ l (ara sezzjoni 4.2).
English: OTHER
Maltese: HEMM
English: Zidovudine is well absorbed from the gut and at all dose levels studied in adults and children, the bioavailability was between 60-74 % with a mean of 65 %.
Maltese: Zidovudine hu assorbit tajjeb mill-imsaren u fil-livelli tad-dożi kollha studjati fl-adulti u t-tfal, il-bijodisponibilità kienet ta' bejn 60-74 % b'medja ta' 65 %.
English: If gastrointestinal intolerance occurs in patients weighing 21-30 kg, an alternative dosing schedule with one-half tablet taken thrice daily can be applied in attempt to improve tolerability.
Maltese: Jekk ikun hemm intolleranza gastrointestinali f'pazjenti li jiżnu bejn 21- 30 kg, skeda ta' doża alternattiva b'nofs pillola li tittieħed 3 darbiet kuljum tista' tiġi applikata f'tentattiv biex titjib it-tollerabilità
English: There are no additional precautions and warnings relevant to the combination Lamivudine/Zidovudine Teva.
Maltese: Mhemmx prekawzjonijiet u twissijiet addizjonali rilevanti għal kombinazzjoni Lamivudine/Zidovudine Teva.
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited binding to the major plasma protein albumin (<36 % serum albumin in vitro).
Maltese: 1.3 l/kg u ta' 1.6 l/kg rispettivament. Lamivudine jesebixxi farmakokinetiċi lineari fyq il-firxa tad-doża terapewtika u juri rabta limitata mal-proteina fil-plażma prinċipali, l-albumina (<36 % serum albumin in vitro).
English: In six HIV-infected children from 2 to 13 years of age, zidovudine plasma pharmacokinetics were evaluated while subjects were receiving 120 mg/m2 zidovudine three times daily and again after switching to 180 mg/m2 twice daily.
Maltese: F'sitt itfal infettati b'HIV bejn l-etajiet ta' sentejn sa 13-il sena, il-farmakokinetiċi ta' zidovudine fil-plażma kienu evalwati waqt li individwi kienu qed jieħdu 120 mg/m2 zidovudine tliet darbiet kuljum u wkoll wara li nqalbu għal 180 mg/m2 darbtejn kuljum.
English: Clarithromycin/Zidovudine (500 mg twice daily/100 mg every 4 hours)
Maltese: Clarithromycin/Zidovudine (500 mg darbtejn kuljum/100 mg kull 4 sigħat)
English: Haematological parameters should therefore be carefully monitored (see section 4.3) in patients receiving Lamivudine/Zidovudine Teva.
Maltese: Parametri ematoloġiċi għandhom għalhekk jiġu mmonitorati b'attenzjoni (ara sezzjoni 4.3) f'pazjenti li qed jirċievu Lamivudine/Zidovudine Teva.
English: White, capsule shaped, biconvex, film-coated scored tablet - engraved with “L/Z” on one side and “150/300” on the other side.
Maltese: Pillola miksija b'rita Pillola bajda, f'għamla ta' kapsula, mżaqqa fuq żewġ naħat miksija b'rita u bil-ferq - li fuqha hemm imnaqqax “L/Z” fuq in-naħa waħda u “150/300” fuq in-naħa l-oħra.
English: The clinically relevant effects of lamivudine and zidovudine in combination are anaemia, neutropenia and leucopenia.
Maltese: L-effetti kliniċi rilevanti ta' lamivudine u zidovudine f'kombinazzjoni huma anemija, newtropenija u lewkopenija.
English: Mitochondrial dysfunction: nucleoside and nucleotide analogues have been demonstrated in vitro and in vivo to cause a variable degree of mitochondrial damage.
Maltese: Disfunzjoni tal-mitokondrija: analogi ta' nuklejosidi u nuklejotidi ntwerew li jikkawżaw gradi differenti ta' ħsara fil-mitokondrija in vitro u in vivo.
English: • pyrimethamine, to treat malaria and other parasitic infections
Maltese: • pyrimethamine, biex jikkura l-malarja u infezzjonijiet parassitiċi oħra
English: In vitro lamivudine inhibits the intracellular phosphorylation of cladribine leading to a potential risk of cladribine loss of efficacy in case of combination in the clinical setting.
Maltese: Interazzjoni mhux studjata In-vitro lamivudine jwaqqaf il fosforrilizzazzjoni intraċellulari ta' cladribine li potenzjalment twassal għal riskju ta' nuqqas ta' effiċċjenza ta' cladribine filkażijiet ta' taħlit fl-isfond kliniku.
English: Dose reduction is required for patients with creatinine clearance ≤50 ml/min (see section 4.2).
Maltese: It-tnaqqis fid-doża huwa meħtieġ għal pazjenti bi tneħħija mill kreatinina ta' ≤50 ml/min (ara sessjoni 4.2).
English: Zidovudine plasma protein binding is 34 % to 38 %.
Maltese: Ir-rabta ta' zidovudine mal-proteini hi ta' 34 % sa 38 %.
English: In vitro data tend to suggest that the continuation of lamivudine in anti-retroviral regimen despite the development of M184V might provide residual anti-retroviral activity (likely through impaired viral fitness).
Maltese: Tagħrif in vitro għandu t-tendenza li juri li l-kontinwazzjoni ta' lamivudine fi programm ta' kura antiretrovirali minkejja li l-iżvilupp ta' M184V jista' jipprovdi attività antiretrovirali residwa (li tista' tiġri minħabba li l-virus ma jibqax jiffunzjona sewwa).
English: Signs of lactic acidosis include:
Maltese: Aċidożi lattika:
English: Renal clearance of zidovudine is estimated to be 0.34 l/h/kg, indicating glomerular filtration and active tubular secretion by the kidneys.
Maltese: It-tneħħija mill-kliewi ta' zidovudine hi stmata li tkun ta' 0.34 l/h/kg, li jindika filtrazzjoni glomerulari u tnixxija tubulari attiva mill-kliewi.
English: Rare side effects These may affect up to 1 in 1000 people:
Maltese: Effetti sekondarji rari ħafna Dawn jistgħu jaffettwaw sa persuna waħda minn kull 10,000:
English: The likelihood of metabolic drug interactions with lamivudine is low due to the small extent of hepatic metabolism (5-10 %) and low plasma binding.
Maltese: Il-probabilità ta' interazzjonijiet ma' mediċini oħra b'lamivudine huwa baxx minħabba li ma tantx ikun hemm metaboliżmu mill-fwied (5-10 %) u trabta baxxa mal-plażma
English: • fits (convulsions)
Maltese: aċċessjonijiet (konvulżjonijiet)
English: • interferon, to treat viral infections
Maltese: • interferon, biex jikkura infezzjonijiet virali
English: • cough
Maltese: • gass
English: Lamivudine has not been specifically investigated in HIV patients co-infected with HBV.
Maltese: Lamivudine ma ġiex mistħarreġ speċifikament f'pazjenti bl-HIV ko-infettati bl-HBV
English: Zidovudine and stavudine maintain their antiretroviral activities against lamivudine-resistant HIV-1.
Maltese: Zidovudine u stavudine iżommu l-attivitajiet antiretrovirali tagħhom kontra l-HIV-1 li jkunu reżistenti għal lamivudine.
English: • hair loss (alopecia).
Maltese: • jaqa' x-xagħar (alopeċja).
English: Each pack type contains 60 film-coated tablets.
Maltese: Kull pakkett fih 60 pillola miksija b'rita.
English: - The active substances are lamivudine 150 mg and zidovudine 300 mg. - The other ingredients are: Tablet core: Cellulose microcrystalline, sodium starch glycolate (Type A), sodium stearyl fumarate.
Maltese: Il-qalba tal-pillola: Cellulose microcrystalline, sodium starch glycollate (Tip A), sodium stearyl fumerate.
English: • breakdown of muscle tissue
Maltese: • diżintegrazzjoni tat-tessut tal-muskolu
English: Resistance to thymidine analogues (of which zidovudine is one) is well characterised and is conferred by the stepwise accumulation of up to six specific mutations in the HIV reverse transcriptase at codons 41, 67, 70, 210, 215 and 219.
Maltese: Ir-reżistenza għal analogi ta' thymidine (li zidovuline hu wieħed minnhom) huwa kkaraterizzat tajjeb u hu konferit bl-akkumulazzjoni pass wara pass sakemm jilħaq sitt mutazzjonijiet speċifiċi fl-HIV reverse transcriptase ta' kodons 41, 70, 210, 215 u 219.
English: • sodium valproate, to treat epilepsy
Maltese: • sodium valproate, biex jikkura l-epilessija
English: Lamivudine and zidovudine are well absorbed from the gastrointestinal tract.
Maltese: Lamivudine u zidovudine huma assorbiti tajjeb mill-passaġġ gastrointestinali.
English: Rifampicin/Zidovudine (600 mg once daily/200 mg thrice daily)
Maltese: Rifampicin/Zidovudine (600 mg darba kuljum/200 mg tliet darbiet kuljum )
English: Uncommon: Myopathy
Maltese: Mhux komuni: Gass
English: The 5'-glucuronide of zidovudine is the major metabolite in both plasma and urine, accounting for approximately 50-80 % of the administered dose eliminated by renal excretion.
Maltese: Il-5'-glucuronide ta' zidovudine huwa l-metabolit prinċipali kemm fil-plażma u l-awrina, li jgħodd għal madwar 50-80% tad-doża amministrata eliminata b'eliminazzjoni mill-kliewi.
English: Lamivudine has not shown any genotoxic activity in in vivo studies at doses that gave plasma concentrations up to 40-50 times higher than clinical plasma levels.
Maltese: Lamivudine ma kienx ġenotossiku in vivo f'dożi li rriżultaw f'konċentrazzjonijiet fil-plażma ta' 40-50 darba iktar mil-livelli ta' plażma klinika.
English: The mean systemic clearance of lamivudine is approximately 0.32 l/h/kg, with predominantly renal clearance (>70 %) via the organic cationic transport system.
Maltese: 0.32 l/h/kg, bi tneħħija prinċipali mill-kliewi (>70 %) permezz tas-sistema tat-trasport katajoniku organiku.
English: • ribavirin or injections of ganciclovir to treat viral infections
Maltese: • ribavirin, jew injezzjonijiet ta' ganciclovir biex tikkura infezzjonijiet virali
English: Early symptoms (symptomatic hyperlactatemia) include benign digestive symptoms (nausea, vomiting and abdominal pain) non-specific malaise, loss of appetite, weight loss, respiratory symptoms (rapid and/or deep breathing) or neurological symptoms (including motor weakness).
Maltese: Sintomi tal-bidu (iperlaktatemjia sintomatika) jinkludu sintomi beninni fid-diġestjoni (dardir, remettar u uġigħ ta, żaqq), telqa bla raġuni speċifika, nuqqas t' aptit, nuqqas fil-piż, sintomi respiratorji (nifs mgħaġġel u/jew nifs qawwi) jew sintomi newroloġiċi (inkluż muskoli dgħajfa).
English: The dosing regimen for paediatric patients weighing 14-30 kg is based primarily on pharmacokinetic modelling and supported by data from clinical studies using the individual components lamivudine and zidovudine.
Maltese: Il-programm ta' kura għal pazjenti pedjatriċi li jiżnu bejn 14-30 kg huwa prinċipalment ibbażżat fuq mudelli farmakokinetiċi u sostnut b'tagħrif mill-istudji kliniċi bl-użu tal-komponenti individwali,lamivudine u zidovudine.
English: Respiratory, thoracic and mediastinal disorders Common: Cough, nasal symptoms
Maltese: Disturbi respiratorji, toraċiċi u medjastinali Komuni: Sogħla, sintomi fl-imnieħer
English: Fluconazole/Zidovudine (400 mg once daily/200 mg thrice daily)
Maltese: Fluconazole/Zidovudine (400 mg darba kuljum/200 mg tliet darbiet kuljum)
English: Haemodialysis and peritoneal dialysis appear to have a limited effect on elimination of zidovudine, but enhance the elimination of the glucuronide metabolite.
Maltese: L-emodijalisi u d-dijalisi peritoneali jidhru li għandhom effett limitat fuq l-eliminazzjoni ta' zidovudine, imma jħarxu l-eliminazzjoni tal-metabolit ta' glucorinide.
English: Musculoskeletal and connective tissue disorders Common: Arthralgia, muscle disorders Rare: Rhabdomyolysis
Maltese: Disturbi muskolu-skeletriċi u tat-tessut konnettiv Komuni: Artralġja, disturbi fil-muskoli
English: Both of these belong to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Maltese: It-tnejn li huma jagħmlu parti minn grupp ta' mediċini antiretrovirali msejħa inibituri ta' reverse transcriptase analogi għal nucleoside (NRTI).
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
Maltese: Pazjenti li kienu diġa' jbatu b'disfunzjoni tal-fwied, inkluża l-epatite kronika attiva, ikollhom żieda fil-frekwenza ta' anormalitajiet fil-funzjoni tal-fwied waqt it-terapija kombinata antiretrovirali, u għandhom ikunu mmonitorjati skont il-prattika standard.
English: • irritated or runny nose
Maltese: • mnieħer irritat jew inixxi
English: Consider more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided.
Maltese: Ikkunsidra monitoraġġ aktar frekwenti tat tagħbija virali tal-HIV-1 meta l-għoti flimkien kroniku ma jkunx jista' jiġi evitat.
English: Probenecid/Zidovudine (500 mg four times daily/2 mg/kg thrice daily)
Maltese: Probenecid/Zidovudine (500 mg erba' darbiet kuljum/2mg/kg tliet darbiet kuljum)
English: Cases of lactic acidosis, sometimes fatal, usually associated with severe hepatomegaly and hepatic steatosis, have been reported with the use of zidovudine (see section 4.4).
Maltese: Każijiet ta' aċidosi lattika, xi kultant fatali, ġeneralment assoċjata ma' epatomegali severa u steatosi epatika ġew rapportati bl-użu ta' zidovudine (ara sezzjoni 4.4)
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breastfed infants of mothers treated for HIV are very low (< 4% of maternal serum concentrations) and progressively decrease to undetectable levels when breastfed infants reach 24 weeks of age.
Maltese: Abbażi ta' aktar minn 200 par ta' omm/wild ikkurati għall-HIV, il-konċentrazzjonijiet ta' lamivudine fis-serum fi trabi mreddgħin ta' ommijiet ikkurati għal HIV huma baxxi ħafna (< 4% talkonċentrazzjonijiet fis-serum maternali) u jonqsu progressivament għal livelli li ma jiġux rilevati meta trabi mreddgħin jilħqu l-età ta' 24 ġimgħa.
English: • tiredness, lack of energy
Maltese: • għeja, nuqqas ta' enerġija
English: Zidovudine AUC ↑74% (UGT inhibition)
Maltese: L-AUC ta' Zidovudine ↑74% (impediment ta' UGT)
English: Both medicinal products are metabolised intracellularly to their active moieties, lamivudine 5'-triphosphate (TP) and zidovudine 5'-TP respectively.
Maltese: Iżżewġ prodotti mediċinali huma metabolizzati ġoċ-ċelluli għall-mojetijiet attivi tagħhom, lamivudine 5'
English: • stavudine or zalcitabine, to treat HIV infection
Maltese: • stavudine jew zalcitabine, biex tikkura infezzjoni bl-HIV
English: Peripheral blood lymphocytes from AIDS patients receiving zidovudine treatment have also been observed to contain higher numbers of chromosome breakages.
Maltese: Limfoċiti periferali fid-demm minn pazjenti bll-AIDS li kienu qed jirċievu t-trattament ta' zidovudine ġew osservati wkoll li għandhom numru ogħla ta' ksur kromosomali.
English: • emtricitabine, to treat HIV infection
Maltese: • emtricitabine, biex tikkura infezzjoni bl-HIV
English: Luxembourg/Luxemburg ratiopharm GmbH Allemagne/Deutschland Tél: +49 731 402 02
Maltese: Luxembourg/Luxemburg ratiopharm GmbH Allemagne/Deutschland
English: The study demonstrated that foetuses exposed in utero to the combination sustained a higher level of nucleoside analogue-DNA incorporation into multiple foetal organs, and showed evidence of more telomere shortening than in those exposed to zidovudine alone.
Maltese: L-istudju wera li feti esposti in utero għall-kombinazzjoni sostnew livell ogħla ta' inkorporazzjoni ta' analogi nukleosidi ta' DNA għal organi fetali multipli u wera evidenza ta' aktar tqassir ta' telomeres minn dawk esposti għal zidovudine waħedhom.
English: Children weighing between 21 kg and 30 kg: the recommended oral dose of Lamivudine/Zidovudine Teva is one-half tablet taken in the morning and one whole tablet taken in the evening.
Maltese: Tfal li jiżnu minn 21 kg u 30 kg: id-doża orali rakkomandata ta' Lamivudine/Zidovudine Teva hi ta' nofs pillola filgħodu u waħda sħiħa filgħaxija.
English: Neither zidovudine nor lamivudine have shown evidence of impairment of fertility in studies in male and female rats.
Maltese: La zidovudine u lanqas lamivudine ma wrew evidenza ta' indeboliment tal-fertilità fi studji f'firien irġiel u nisa.
English: Swallow Lamivudine/Zidovudine Teva tablets with some water.
Maltese: Ibla' l-pilloli Lamivudine/Zidovudine Teva ma' ftit ilma.
English: • fluconazole or flucytosine, to treat fungal infections such as candida
Maltese: • fluconazole jew flucytosine, biex jikkura infezzjonijiet bil-fungu bħal candida
English: Treatment with zidovudine should be discontinued if there is symptomatic hyperlactatemia and metabolic/lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.
Maltese: Il-kura b'zidovudine għandha titwaqqaf malli jidhru sintomi ta' iperlaktatemja u aċidożi metabolika/lattika, epatomegalija progressiva, jew żjieda mgħaġġla fil-livelli tal-aminotransferase.
English: Some medicines interact with Lamivudine/Zidovudine Teva
Maltese: Mediċini oħra u Lamivudine/Zidovudine Teva
English: Lamivudine/Zidovudine Teva 150 mg/300 mg film-coated tablets lamivudine/zidovudine
Maltese: Lamivudine/Zidovudine Teva 150 mg/300 mg pilloli miksijin b'rita lamivudine/zidovudine
English: Atovaquone/Zidovudine (750 mg twice daily with food/200 mg thrice daily)
Maltese: Atovaquone/Zidovudine (750 mg darbtejn kuljum malikel/200 mg tliet darbiet kuljum)
English: • other medicinal products containing lamivudine, to treat HIV infection or hepatitis B infection
Maltese: • prodotti mediċinali oħra li fihom lamivudine, biex tikkura infezzjoni bl-HIV jew tal-epatite B
English: Mitochondrial dysfunction following exposure in utero: Nucleoside and nucleotide analogues may impact mitochondrial function to a variable degree, which is most pronounced with stavudine, didanosine and zidovudine.
Maltese: Analogi nukleosidi u nukleotidi jistgħu jaffettwaw il-funzjoni mitokondrijali sa grad varjabbli, li hija l-iktar evidenti bi stavudine, didanosine u zidovudine.
English: Dosage adjustments in patients with haematological adverse reactions: Dosage adjustment of zidovudine may be necessary if the haemoglobin level falls below 9 g/dl or 5.59 mmol/l or the neutrophil count falls below 1.0 x 109/l (see sections 4.3 and 4.4).
Maltese: Aġġustamenti għad-doża f'pazjenti b'reazzjonijiet ematoloġiċi avversi: Aġġustament tad-doża għal zidovudine jista' jkun meħtieġ jekk l-emaglobina taqa' inqas minn 9 g/dl jew 5.59 mmol/l jew l-għadd ta' newtrofili taqa' inqas minn 1.0 x 109/l (ara sezzjonijiet 4.3 u 4.4).
English: Pancreatitis
Maltese: REĊIPJENTI
English: Children weighing from 14 kg to 21 kg: the recommended oral dose of Lamivudine/Zidovudine Teva is one-half tablet taken twice daily.
Maltese: Tfal li jiżnu minn 14 kg sa 21 kg: id-doża orali rakkomandata ta' Lamivudine/Zidovudine Teva hi ta' nofs pillola li tittieħed darbtejn kuljum.
English: One year post-natally, there was an increase in the incidence of tumours in the lung, liver and female reproductive tract of offspring exposed to the highest dose level (420 mg/kg term body weight).
Maltese: Sena wara t-twelid kien hemm żieda fl-inċidenza ta' tumuri fil-pulmun, u l-passaġġ riproduttiv tal-mara ta' wild espost għall-ogħla livell ta' doża (420 mg/kg piż tal-ġisem fit-terminu).
English: Zidovudine AUC ↑80% (UGT inhibition)
Maltese: L-AUC ta' Zidovudine ↑80% (impediment ta' UGT)
English: Lactic acidosis is a rare but serious side effect
Maltese: Jekk ikollok effetti sekondarji
English: Viruses acquire phenotypic resistance to thymidine analogues through the combination of mutations at codons 41 and 215 or by the accumulation of at least four of the six mutations.
Maltese: Il-vajrusis jiksbu reżistenza għal analogi ta' thymidine permezz tal-kombinazzjoni ta' mutazzjonijiet f'kodons 41 u 215 jew bl-akkumulazzjoni ta' mill-inqas 4 mis-sitt mutazzjonijiet.
English: In addition, systemic clearance values were greater in younger paediatric patients and decreased with age, approaching adult values around 12 years of age.
Maltese: Barra minn hekk, valuri sistemiċi ta' tneħħija kienu akbar f'pazjenti pedjatriċi iżgħar u naqqsu bl-età, u jilħqu livelli ta' madwar l-adulti madwar l-età ta' 12-il sena.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterium infections, and Pneumocystis jirovecii pneumonia (often referred to as PCP).
Maltese: Eżempji rilevanti jinkludu retinite b'ċitomegalovirus, infezzjonijiet mikobatterjali lokali jew mifruxa, u pulmonite b'Pneumocystis jirovecii (li ħafna drabi ssir referenza għaliha bħala PCP [Pneumocystis jirovecii pneumonia]).
English: Pharmacotherapeutic group: Antivirals for treatment of HIV infections, combinations, ATC Code: J05AR01
Maltese: Antivirali għal kura ta' infezzjonijiet ta' HIV, kombinazzjonijiet, Kodiċi
English: For children who weigh less than 14 kg lamivudine and zidovudine (the ingredients of Lamivudine/Zidovudine Teva) should be taken separately.
Maltese: Għal tfal li jiżnu anqas minn 14-il kg lamivudine u zidovudine (is-sustanzi ta' Lamivudine/Zidovudine Teva) għandhom jittieħdu separatament.
English: The relationship between in vitro susceptibility of HIV to lamivudine and zidovudine and clinical response to lamivudine/zidovudine containing therapy remains under investigation.
Maltese: Ir-relazzjoni bejn suxxetibilità in vitro ta' HIV għal lamivudine u r-rispons kliniku għal terapija li fihom lamivudine/zidovudine tibqa' tiġi mistħarrġa.
English: Lamivudine and zidovudine are nucleoside analogues which have activity against HIV.
Maltese: J05AF01 Lamivudine u zidovudine huma analogi nuklejosidi li jaġixxu kontra l-virus ta' immunodefiċjenza fil-bniedem (HIV).
English: Each film-coated tablet contains lamivudine 150 mg zidovudine 300 mg
Maltese: Kull pillola miksija b'rita fiha lamivudine 150 mg zidovudine 300 mg
English: Some clinical findings also support a possible interaction between lamivudine and cladribine
Maltese: Ċerti sejbiet kliniċi ukoll juru l-possibiltà ta' interazzjoni bejn lamivudine u cladribine.