FrancophonIA/ELRC3.0 huggingface dataset:
English: Possibly histamine-mediated adverse reactions, including rash, facial swelling, angioedema, pruritus, sensation of warmth, or bronchospasm have been reported and may require discontinuation and/or administration of appropriate treatment.
Croatian: Prijavljene su nuspojave koje bi mogle biti posredovane histaminom, uključujući osip, oticanje lica, angioedem, pruritus, osjećaj topline ili bronhospazam zbog kojih bi moglo biti nužno prekinuti liječenje i/ili primijeniti odgovarajuće liječenje.
English: Studies in vitro and in vivo demonstrate that exposure of Aspergillus to caspofungin results in lysis and death of hyphal apical tips and branch points where cell growth and division occur.
Croatian: Ispitivanja in vitro i in vivo pokazuju da izlaganje Aspergillusa kaspofunginu dovodi do lize i smrti hifa na vrhovima i mjestima grananja na kojima se odvija rast i dioba stanice.
English: Reduced volume infusions in 100 mL may be used, when medically necessary, for 50 mg or 35 mg daily doses.
Croatian: Može se koristiti i infuzija manjeg volumena od 100 ml, kad za to postoje medicinski razlozi, za primjenu dnevne doze od 50 mg ili 35 mg.
English: Caspofungin trough levels gradually decreased upon repeated administration.
Croatian: Najniža koncentracija kaspofungina postupno se snižavala s ponovnom primjenom.
English: There is no clinical experience in adult patients with severe hepatic impairment (Child-Pugh score greater than 9) and in paediatric patients with any degree of hepatic impairment (see section 4.4).
Croatian: Ne postoji kliničko iskustvo s liječenjem odraslih bolesnika s teškim oštećenjem funkcije jetre (više od 9 bodova na Child-Pugh ljestvici) i pedijatrijskih bolesnika s bilo kojim stupnjem oštećenja funkcije jetre (vidjeti dio 4.4).
English: The average exposure in an adult patient weighing 80 kg was predicted to be about 23 % lower than in an adult patient weighing 60 kg (see section 4.2).
Croatian: Procjenjuje se da je prosječna izloženost djelovanju kaspofungina u odraslog bolesnika teškog 80 kg oko 23% manja od one u odraslog bolesnika teškog 60 kg (vidjeti dio 4.2).
English: The study excluded patients with suspected Candida endocarditis, meningitis, or osteomyelitis.
Croatian: Iz ispitivanja su bili isključeni bolesnici sa sumnjom na endokarditis, meningitis ili osteomijelitis prouzročen Candidom.
English: Alternatively, the volume (mL)c of reconstituted Caspofungin Accord can be added to a reduced volume of 0.9 %,
Croatian: Alternativno možete dodati volumen (ml)c rekonstituiranog lijeka Caspofungin Accord u smanjeni volumen 0,9%, 0,45% ili
English: Caspofungin Accord will always be prepared and given to you by a healthcare professional.
Croatian: Caspofungin Accord će Vam uvijek pripremiti i primijeniti zdravstveni radnik.Caspofungin Accord će Vam biti primijenjen:
English: People who might get this type of infection include those having chemotherapy, those who have had a transplant and those whose immune systems are weak.
Croatian: Osobe koje bi mogle dobiti ovu vrstu infekcije uključuju osobe koje primaju kemoterapiju, osobe koje su imale transplantaciju ili osobe čiji je imunološki sustav oslabljen.
English: The white to off-white compact lyophilised powder will dissolve completely.
Croatian: Bijeli do bjelkasti kompaktni liofilizirani prašak potpuno će se otopiti.
English: Favourable response rates in neutropaenic patients were 7/14 (50 %) in the caspofungin group and 4/10 (40 %) in the amphotericin B group.
Croatian: Stopa povoljnog odgovora u bolesnika s neutropenijom bila je 7/14 (50%) u skupini koja je primala kaspofungin i 4/10 (40%) u skupini koja je primala amfotericin B.
English: Calculation of Body Surface Area (BSA) for paediatric dosing
Croatian: Izračun površine tijela (PT) za doziranje u pedijatrijskih bolesnika
English: However, in adult patients with invasive candidiasis, oesophageal candidiasis, or invasive aspergillosis who received multiple daily doses of caspofungin 50 mg, there was no significant effect of mild to advanced renal impairment on caspofungin concentrations.
Croatian: Međutim, u odraslih bolesnika s invazivnom kandidijazom, kandidijazom jednjaka ili invazivnom aspergilozom, koji su primili više dnevnih doza kaspofungina od 50 mg, blago do uznapredovalo oštećenje funkcije bubrega nije značajno utjecalo na koncentraciju kaspofungina.
English: The safety and efficacy of caspofungin have not been sufficiently studied in clinical trials involving neonates and infants below 12 months of age.
Croatian: Sigurnost primjene i djelotvornost kaspofungina nisu dovoljno ispitani u kliničkim ispitivanjima u novorođenčadi i dojenčadi mlađoj od 12 mjeseci.
English: Increased caspofungin exposure was seen in adult patients with renal impairment and mild liver impairment, in female subjects, and in the elderly.
Croatian: Povećana izloženost kaspofunginu primijećena je u odraslih bolesnika s oštećenjem funkcije bubrega i blagim oštećenjem funkcije jetre, u ženskih ispitanica i u starijih bolesnika.
English: 564 febrile neutropaenic patients (empirical therapy study), 382 patients with invasive candidiasis, 228 patients with invasive aspergillosis, 297 patients with localised Candida infections, and 394 individuals enrolled in Phase I studies.
Croatian: U kliničkim je ispitivanjima 1865 odraslih ispitanika primilo pojedinačnu ili višekratnu dozu kaspofungina: 564 febrilnih bolesnika s neutropenijom (ispitivanje empirijskog liječenja), 382 bolesnika s invazivnom kandidijazom, 228 bolesnika s invazivnom aspergilozom, 297 bolesnika s lokaliziranim infekcijama Candidom i 394 ispitanika uključenih u fazu
English: • Abnormal skin tissue, generalised itching, hives, rash of varying appearance, abnormal skin, red often itchy spots on your arms and legs and sometimes on the face and the rest of the body
Croatian: • Promjene tkiva kože, generalizirani svrbež, koprivnjača, osip raznolikog izgleda, promjene kože, crvene mrlje na rukama i nogama koje često svrbe, a ponekad se javljaju i na licu i ostatku tijela
English: Caspofungin did not influence the pharmacokinetics of amphotericin B, itraconazole, rifampicin or mycophenolate mofetil.
Croatian: Kaspofungin nije utjecao na farmakokinetiku amfotericina B, itrakonazola, rifampicina ili mikofenolat mofetila.
English: When caspofungin is co-administered to paediatric patients (12 months to 17 years of age) with inducers of drug clearance, such as rifampicin, efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine, a caspofungin dose of 70-mg/m2 daily (not to exceed an actual daily dose of 70 mg) should be considered.
Croatian: Kad se kaspofungin primjenjuje u pedijatrijskih bolesnika (u dobi od 12 mjeseci do 17 godina) istodobno s induktorima klirensa lijekova, kao što su rifampicin, efavirenz, nevirapin, fenitoin, deksametazon ili karbamazepin, potrebno je razmotriti primjenu doze kaspofungina od 70 mg/m2 dnevno (koja ne smije biti veća od 70 mg na dan).
English: For adult patients with mild hepaticimpairment (Child-Pugh score 5 to 6), no dosage adjustment is needed.
Croatian: U odraslih bolesnika s blagim oštećenjem funkcije jetre (5 do 6 bodova na Child-Pugh ljestvici) nije potrebno prilagođavati dozu.
English: Studies in vitro show that caspofungin is not an inhibitor of any enzyme in the cytochrome P450 (CYP) system.
Croatian: Ispitivanja in vitro pokazuju da kaspofungin ne inhibira niti jedan enzim u sustavu citokroma P450 (CYP).
English: Although safety data are limited it appears that no special precautions are needed when amphotericin B, itraconazole, nelfinavir or mycophenolate mofetil are co-administered with caspofungin.
Croatian: Premda su podaci o sigurnosti primjene ograničeni, čini se da nisu potrebne posebne mjere opreza kad se amfotericin B, itrakonazol, nelfinavir ili mikofenolat mofetil primjenjuju istodobno s kaspofunginom.
English: In paediatric patients, results from regression analyses of pharmacokinetic data suggest that co-administration of dexamethasone with caspofungin may result in clinically meaningful reductions in caspofungin trough concentrations.
Croatian: Rezultati regresijske analize farmakokinetičkih podataka, prikupljenih u pedijatrijskih bolesnika, pokazuju da istodobna primjena deksametazona s kaspofunginom može dovesti do klinički značajnog sniženja najniže koncentracije kaspofungina.
English: Limited data suggest that caspofungin at 25 mg/m2 daily in neonates and infants (less than 3 months of age) and 50 mg/m2 daily in young children (3 to 11 months of age) can be considered (see section 5.2).
Croatian: Ograničeni podaci pokazuju da se može uzeti u obzir primjena kaspofungina u dozi od 25 mg/m2 jedanput na dan u novorođenčadi i dojenčadi (mlađih od 3 mjeseca) i 50 mg/m2 jedanput na dan u male djece (u dobi od 3 do 11 mjeseci) (vidjeti dio 5.2).
English: Similarly, C. parapsilosis isolates intermediate to anidulafungin and micafungin can be regarded intermediate to caspofungin.
Croatian: Slično tome, izolati vrste C. parapsilosis intermedijarno osjetljivi na anidulafungin i mikafungin mogu se smatrati intermedijarno osjetljivima na kaspofungin.
English: Hepatobiliary disorders elevated liver values (alanine aminotransferase, aspartate aminotranserase, blood alkaline phosphatase, bilirubin conjugated, blood bilirubin)
Croatian: Poremećaji jetre i žuči povišene vrijednosti jetrenih nalaza (alanin aminotransferaza, aspartat aminotransferaza, alkalna fosfataza u krvi, konjugirani bilirubin, bilirubin u krvi)
English: Some healthy adult volunteers who received two 3 mg/kg doses of cyclosporin with caspofungin showed transient increases in alanine transaminase (ALT) and aspartate transaminase (AST) of less than or equal to 3-fold the upper limit of normal (ULN) that resolved with discontinuation of the treatment.
Croatian: U nekih zdravih dobrovoljaca, koji su primili dvije doze po 3 mg/kg ciklosporina s kaspofunginom, uočen je prolazni porast vrijednosti alanin-transaminaze (ALT) i aspartattransaminaze (AST) koje su bile do najviše 3 puta veće od gornje granice normale i koje su se vratile na početne vrijednosti nakon prekida terapije.
English: Susceptibility testing was performed according to a modification of both the Clinical and Laboratory Standards Institute (CLSI, formerly known as the National Committee for Clinical Laboratory Standards [NCCLS]) method M38-A2 (for Aspergillus species) and method M27-A3 (for Candida species).
Croatian: Provedeno je testiranje osjetljivosti prema modificiranoj metodi M38-A2 (za vrste roda Aspergillus), kao i metodi M27-A3 (za vrste roda Candida)
English: Limited data from population pharmacokinetics studies indicate that concomitant use of caspofungin with the inducers efavirenz, nevirapine, rifampicin, dexamethasone, phenytoin, or carbamazepine may result in a decrease in caspofungin AUC.
Croatian: Ograničeni podaci iz ispitivanja populacijske farmakokinetike pokazuju da istodobna primjena kaspofungina i induktora kao što su efavirenz, nevirapin, rifampicin, deksametazon, fenitoin ili karbamazepin može dovesti do smanjenja AUC-a kaspofungina.
English: What Caspofungin Accord is and what it is used for
Croatian: Što je Caspofungin Accord i za što se koristi
English: The favourable response rates for patients who were either refractory to or intolerant of previous therapies were 36 % (19/53) and 70 % (7/10), respectively.
Croatian: Stopa povoljnih odgovora u bolesnika koji su imali infekciju otpornu na liječenje bila je 36% (19/53), a u onih koji nisu podnosili prethodnu terapiju bila je 70% (7/10).
English: Stability data have shown that the product can be used within 24 hours when stored at 25°C or less, or within 48 hours when the intravenous infusion bag (bottle) is stored refrigerated (2 to 8°C) and diluted with sodium chloride solution 9 mg/mL (0.9 %), 4.5 mg/mL (0.45 %), or 2.25 mg/mL (0.225 %) for infusion, or lactated Ringer's solution.
Croatian: Podaci o stabilnosti pokazuju da se lijek može primijeniti u roku od 24 sata kad se čuva pri temperaturi od 25°C ili nižoj, ili u roku od 48 sati kad se infuzijska vrećica (boca) za intravensku primjenu čuva u hladnjaku (2°C do 8°C) i kad je razrijeđena otopinom natrijevog klorida za infuziju od 9 mg/ml (0,9 %), 4,5 mg/ml (0,45 %) ili 2,25 mg/ml (0,225 %) ili Ringerovom otopinom s laktatom.
English: Most patients had underlying conditions (haematologic malignancy [N = 24], allogeneic bone marrow transplant or stem cell transplant [N = 18], organ transplant [N = 8], solid tumour [N = 3], or other conditions [N = 10]).
Croatian: Većina bolesnika imala je neku drugu osnovnu bolest (zloćudna hematološka bolest [N = 24], presađivanje alogenične koštane srži ili matičnih stanica [N = 18], presađeni organ [N = 8], solidni tumor [N = 3] ili neku drugu bolest [N = 10]).
English: What you need to know before you are given Caspofungin Accord
Croatian: Što morate znati prije nego počnete primati Caspofungin Accord
English: Caspofungin 50 mg once daily was administered following a 70 mg loading dose, while amphotericin B was administered at 0.6 to 0.7 mg/kg/day to non-neutropaenic patients or 0.7 to 1.0 mg/kg/day to neutropaenic patients.
Croatian: Kaspofungin se primjenjivao u dozi od 50 mg jedanput na dan nakon udarne doze od 70 mg, dok se amfotericin B primjenjivao u dozi od 0,6 do 0,7 mg/kg/dan u bolesnika koji nisu imali neutropeniju ili u dozi od 0,7 do 1,0 mg/kg/dan u bolesnika s neutropenijom.
English: This finding may indicate that paediatric patients will have similar reductions with inducers as seen in adults.
Croatian: Ovaj nalaz može značiti da će primjena induktora u pedijatrijskih bolesnika izazvati slično sniženje najniže koncentracije kaspofungina kakvo se vidi i u odraslih.
English: • Women given Caspofungin Accord should not breast-feed.
Croatian: • Žene koje primaju Caspofungin Accord ne smiju dojiti.
English: In clinical studies, caspofungin did not induce or inhibit the CYP3A4 metabolism of other medicinal products.
Croatian: U kliničkim ispitivanjima kaspofungin nije inducirao niti inhibirao metabolizam drugih lijekova putem CYP3A4.
English: For adult patients with moderate hepatic impairment (Child-Pugh score 7 to 9), Caspofungin 35 mg daily is recommended based upon pharmacokinetic data.
Croatian: U odraslih bolesnika s umjerenim oštećenjem funkcije jetre (7 do 9 bodova na Child-Pugh ljestvici) na temelju farmakokinetičkih podataka preporučuje se Caspofungin u dozi od 35 mg na dan.
English: Caspofungin also has in vitro activity against
Croatian: Kaspofungin također djeluje in vitro protiv vrsta roda
English: The response rates among patients with pulmonary disease and extrapulmonary disease were 47 % (21/45) and 28 % (5/18), respectively.
Croatian: Stopa odgovora u bolesnika s plućnom bolesti bila je 47% (21/45), a u onih s ekstrapulmonarnom bolesti 28% (5/18).
English: The proportion of patients with a serious drug-related adverse reaction or a drug-related adverse reaction leading to caspofungin discontinuation was comparable in the 2 treatment groups.
Croatian: Udio bolesnika s ozbiljnim nuspojavama povezanim s primjenom lijeka ili nuspojavama povezanim s primjenom lijeka zbog kojih se moralo prekinuti liječenje kaspofunginom bio je usporediv u obje skupine.
English: Empirical Therapy in Febrile, Neutropaenic Adult Patients: A total of 1,111 patients with persistent fever and neutropaenia were enrolled in a clinical study and treated with either caspofungin 50 mg once daily following a 70 mg loading dose or liposomal amphotericin B 3.0 mg/kg/day.
Croatian: Empirijsko liječenje odraslih febrilnih bolesnika s neutropenijom: ukupno je 1111 bolesnika s perzistentnom vrućicom i neutropenijom bilo uključeno u kliničko ispitivanje i liječeno kaspofunginom u dozi od 50 mg jedanput na dan nakon udarne doze od 70 mg ili liposomalnim amfotericinom B u dozi od 3,0 mg/kg/dan.
English: • Decreased blood albumin (a type of protein) in your blood, decreased potassium or low potassium levels in the blood
Croatian: • Smanjena količina albumina (vrsta bjelančevina) u krvi, smanjena razina kalija ili niske razine kalija u krvi
English: 4.7 Effects on ability to drive and use machines No studies on the effects on the ability to drive and use machines have been performed.
Croatian: Nisu provedena ispitivanja utjecaja na sposobnost upravljanja vozilima i rada sa strojevima.
English: Caspofungin reduced the trough concentration of tacrolimus by 26 % in healthy adult volunteers.
Croatian: Kaspofungin je u zdravih odraslih dobrovoljaca snizio najnižu koncentraciju takrolimusa za 26%.
English: The maximum loading dose on Day 1 should not exceed 70 mg regardless of the patient's calculated dose.
Croatian: Maksimalna udarna doza 1. dana ne smije biti viša od 70 mg bez obzira na veličinu izračunate doze za bolesnika.
English: The concentrations of the reconstituted vials will be 7.2 mg/mL.
Croatian: Koncentracija rekonstituirane otopine u bočici iznosit će 7,2 mg/ml.
English: Isolates of Candida with reduced susceptibility to caspofungin have been identified in a small number of patients during treatment (MICs for caspofungin >2 mg/L (4- to 30-fold MIC increases) have been reported using standardized MIC testing techniques approved by the CLSI).
Croatian: Izolati rida Candida koji su imali smanjenu osjetljivost na kaspofungin pronađeni su za vrijeme liječenja u malom broju bolesnika (MIK vrijednosti za kaspofungin >2 mg/l (povišenje MIK vrijednosti 4 do 30 puta) zabilježene su prilikom primjene standardiziranog MIK ispitivanja odobrenog od strane CLSI).
English: People who might get this type of infection include those who have just had an operation or those whose immune systems are weak.
Croatian: Osobe koje bi mogle dobiti ovu vrstu infekcije uključuju osobe koje su nedavno operirane ili osobe čiji je imunološki sustav oslabljen.
English: In a retrospective study of 40 patients treated during marketed use with caspofungin and cyclosporin for 1 to 290 days (median 17.5 days), no serious hepatic adverse reactions were noted.
Croatian: U retrospektivnom ispitivanju provedenom na 40 bolesnika koji su primali kaspofungin i ciklosporin od 1 do 290 dana (medijan 17,5 dana) nije bilo prijavljenih ozbiljnih nuspojava povezanih s jetrom.
English: On Day 1, C1 hr was comparable and C24 hr modestly elevated (36 %) in these neonates and infants relative to adults.
Croatian: Prvog je dana C1 h u ove novorođenčadi i dojenčadi bila usporediva s onom u odraslih bolesnika, a C24 h blago povećana (36%).
English: The most frequent diagnoses were bloodstream infections (candidaemia) (77 %, n=186) and Candida peritonitis (8 %, n=19); patients with Candida endocarditis, osteomyelitis, or meningitis were excluded from this study.
Croatian: Najčešće dijagnoze bile su infekcija krvi (kandidemija) (77%, n=186) i peritonitis prouzročen Candidom (8%, n=19).
English: Renal impairment: In a clinical study of single 70 mg doses, caspofungin pharmacokinetics were similar in adult volunteers with mild renal impairment (creatinine clearance 50 to 80 mL/min) and control subjects.
Croatian: Oštećenje funkcije bubrega: u kliničkom ispitivanju pojedinačnih doza od 70 mg farmakokinetika kaspofungina u odraslih dobrovoljaca s blagim oštećenjem funkcije bubrega (klirens kreatinina od 50 do 80 ml/min) bila je slična onoj u kontrolnih ispitanika.
English: Investigations decreased potassium, hypomagnesemia, increased glucose, decreased phosphorus, and increased phosphorus
Croatian: Pretrage snižene vrijednosti kalija, hipomagnezemija, povišene vrijednosti glukoze, snižene vrijednosti fosfora i povišene vrijednosti fosfora
English: Psychiatric anxiety, disorientation, insomnia disorders
Croatian: Psihijatrijski poremećaji anksioznost, dezorijentiranost, nesanica
English: Cardiac disorders palpitations, tachycardia, arrhythmia, atrial fibrillation, cardiac failure congestive
Croatian: Srčani poremećaji palpitacije, tahikardija, aritmija, fibrilacija atrija, kongestivno zatajenje srca
English: Aspergillus flavus [N = 111], Aspergillus niger [N = 31], Aspergillus nidulans [N = 8], Aspergillus terreus [N = 52], and Aspergillus candidus [N = 3]).
Croatian: Kaspofungin djeluje in vitro protiv vrsta roda Aspergillus (Aspergillus fumigatus [N = 75], Aspergillus flavus [N = 111], Aspergillus niger [N = 31], Aspergillus nidulans [N = 8], Aspergillus terreus
English: • Tightening of the bands of muscle around the airways resulting in wheezing or coughing, fast breathing rate, shortness of breath that wakes you up, shortage of oxygen in the blood, abnormal breath sounds, crackling sounds in the lungs, wheezing, nasal congestion, cough, throat pain
Croatian: • Stezanje mišića oko dišnih puteva koje dovodi do piskanja pri disanju ili kašljanja, ubrzano disanje, nedostatak zraka koji bolesnika budi iz sna, nedostatak kisika u krvi, neuobičajeni zvukovi pri disanju, zvukovi pucketanja u plućima, piskanje pri disanju, začepljenost nosa, kašalj, bol u grlu
English: • If you have any further questions, ask your doctor, nurse or pharmacist.
Croatian: • Ako imate dodatnih pitanja, obratite se svom liječniku, medicinskoj sestri ili ljekarniku.
English: If any of the above applies to you (or you are not sure), talk to your doctor, nurse or pharmacist before you are given Caspofungin Accord.
Croatian: Ako se nešto od gore navedenog odnosi na Vas (ili ako niste sigurni), obratite se svom liječniku, medicinskoj sestri ili ljekarniku prije nego primite Caspofungin Accord .
English: • Empirical therapy for presumed fungal infections (such as Candida or Aspergillus) in febrile,
Croatian: • Empirijsko liječenje za pretpostavljene gljivične infekcije (npr. Candida ili Aspergillus) u odraslih ili pedijatrijskih febrilnih bolesnika s neutropenijom.
English: Skin and subcutaneous tissue disorders rash, pruritus
Croatian: Poremećaji kože i potkožnog tkiva osip, pruritus
English: Investigations blood potassium decreased, blood albumin decreased blood creatinine increased, red blood cells urine positive, protein total decreased, protein urine present, prothrombin time prolonged, prothrombin time shortened, blood sodium decreased, blood sodium increased, blood calcium decreased, blood calcium increased, blood chloride decreased, blood glucose increased, blood magnesium decreased, blood phosphorus decreased, blood phosphorus increased, blood urea increased, activated partial thromboplastin time prolonged, blood bicarbonate decreased, blood chloride increased, blood potassium increased, blood pressure increased, blood uric acid decreased, blood urine present, breath sounds abnormal, carbon dioxide decreased, immunosuppressant drug level increased, international normalised ratio increased, urinary casts, white blood cells urine positive, and pH urine increased.
Croatian: Pretrage snižene vrijednosti kalija u krvi, snižene vrijednosti albumina u krvi povišene vrijednosti kreatinina u krvi, mokraća pozitivna na eritrocite, smanjeni ukupni proteini, proteini prisutni u mokraći, produljeno protrombinsko vrijeme, skraćeno protrombinsko vrijeme, snižene vrijednosti natrija u krvi, povišene vrijednosti natrija u krvi, snižene vrijednosti kalcija u krvi, povišene vrijednosti kalcija u krvi, snižene vrijednosti klorida u krvi, povišene vrijednosti glukoze u krvi, snižene vrijednosti magnezija u krvi, snižene vrijednosti fosfora u krvi, povišene vrijednosti fosfora u krvi, povišene vrijednosti ureje u krvi, produljeno aktivirano parcijalno tromboplastinsko vrijeme, snižene vrijednosti bikarbonata u krvi, povišene vrijednosti klorida u krvi, povišene vrijednosti kalija u krvi, povišeni krvni tlak, snižene vrijednosti mokraćne kiseline u krvi, prisutnost krvi u mokraći, promijenjen šum disanja, snižene vrijednosti ugljikovog dioksida, povišena razina imunosupresivnih lijekova, povišen međunarodni normalizirani omjer (INR), cilindri u mokraći, mokraća pozitivna na leukocite i povišeni pH mokraće
English: Of note, the efficacy and safety of caspofungin have not been adequately studied in prospective clinical trials involving neonates and infants under 3 months of age.
Croatian: Potrebno je napomenuti da djelotvornost i sigurnost primjene kaspofungina nisu primjereno ispitane u prospektivnim kliničkim ispitivanjima u novorođenčadi i dojenčadi mlađoj od 3 mjeseca.