FrancophonIA/ELRC3.0 huggingface dataset:
English: 5 - Before attaching the adapter remove and discard the alcohol wipe and rest the vial on a flat surface.
Slovenian: 5 - Pred namestitvijo adapterja odstranite in odvrzite alkoholno blazinico, viala naj bo na ravni površini.
English: − Blood clots in the small blood vessels may occur during your treatment.
Slovenian: − Med zdravljenjem se lahko pojavijo krvni strdki v majhnih krvnih žilah.
English: België / Belgique / Belgien Bayer SA-NV
Slovenian: België / Belgique / Belgien
English: Interferons have been reported to reduce the activity of hepatic cytochrome P450-dependent enzymes in humans and animals.
Slovenian: Poročali so, da interferoni pri ljudeh in živalih zmanjšajo aktivnost jetrnih encimov, odvisnih od encimskega sistema citokrom P450.
English: Injection site necrosis has been reported in patients using Betaferon (see section 4.8).
Slovenian: Pri bolnikih, ki prejemajo zdravilo Betaferon, so poročali o nekrozi na mestu injiciranja (glejte poglavje 4.8).
English: Detailed instructions for self-injection of Betaferon under the skin are provided in Part IE of the Annex 'Self-injection procedure'.
Slovenian: Podrobnejša navodila za samoinjiciranje zdravila Betaferon pod kožo so navedena v delu IE v dodatku - Postopek samoinjiciranja.
English: If you experience any break in the skin, which may be associated with swelling or fluid leaking out from the injection site:
Slovenian: Če bolnik opazi poškodbo kože, ki je lahko povezana z oteklinami ali vlaženjem na mestu injiciranja,
English: If you suffer from severe depression and/or suicidal thoughts, you will not be treated with Betaferon (see also ‘Do not use Betaferon').
Slovenian: Če imate hudo depresijo in/ali samomorilne misli, vam ne bodo predpisali zdravila Betaferon (glejte tudi poglavje Ne uporabljajte zdravila Betaferon).
English: To easily increase the dosage during the first 12 injections, you may be given a special titration pack, containing four differently coloured packs with specially marked syringes and with detailed instructions on the separate introductory leaflet for titration pack.
Slovenian: Za lažje povečevanje odmerkov med prvimi 12 injekcijami, lahko uporabite poseben set za titriranje, ki vsebuje štiri različno obarvana pakiranja s posebej označenimi injekcijskimi brizgami in podrobnejšimi ločenimi navodili za uporabo seta za titriranje.
English: Time to McDonald MS Kaplan-Meier
Slovenian: Čas do McDonald MS Ocena po KaplanMeierjevi metodi
English: If the patient has multiple lesions Betaferon should be discontinued until healing has occurred.
Slovenian: Če ima bolnik več lezij, je treba zdravljenje z zdravilom Betaferon prekiniti, dokler se te ne zacelijo.
English: NOVAGEM Limited
Slovenian: Ireland Bayer Limited
English: Problems with your small blood vessels (capillaries) may develop when using medicines like Betaferon (systemic capillary leak syndrome).
Slovenian: Pri uporabi zdravil kot je Betaferon se lahko pojavijo težave z majhnimi žilami (kapilarami) (sindrom sistemske kapilarne prepustnosti).
English: If the patient fails to respond, for example a steady progression in EDSS for 6 months occurs or treatment with at least 3 courses of ACTH or corticosteroids during a one year period is required despite Betaferon therapy, treatment with Betaferon should be stopped.
Slovenian: Zdravljenje z zdravilom Betaferon je treba prenehati, če se bolnik ne odzove na zdravljenje, npr. če kljub zdravljenju z zdravilom Betaferon stanje glede na EDSS (EDSS - Expanded Disability Status Scale) 6 mesecev nenehno napreduje ali so v enoletnem obdobju kljub zdravljenju z zdravilom Betaferon potrebni vsaj 3 ciklusi zdravljenja z adrenokortikotropnim hormonom (ACTH) ali kortikosteroidi.
English: LIST OF EXCIPIENTS Excipients: Human albumin, mannitol
Slovenian: SEZNAM POMOŽNIH SNOVI Pomožne snovi: humani albumin, manitol
English: Injection site skin and tissue breakdown can result in scars forming.
Slovenian: Zaradi poškodbe kože in tkiva na mestu injiciranja lahko pride do brazgotinjenja.
English: Multipack comprising 15 single packs, each containing: Multipack comprising 5 single packs, each containing: Multipack comprising 14 single packs, each containing: Multipack comprising 12 single packs, each containing:
Slovenian: Škatla z več pakiranji - 15 posameznih pakiranj, vsako vsebuje: Škatla z več pakiranji - 5 posameznih pakiranj, vsako vsebuje: Škatla z več pakiranji - 14 posameznih pakiranj, vsako vsebuje: Škatla z več pakiranji - 12 posameznih pakiranj, vsako vsebuje:
English: - if you currently suffer from severe depression and/or suicidal thoughts (see ‘Warnings and precautions' and section 4 ‘Possible side effects').
Slovenian: - če imate trenutno hudo depresijo, samomorilne misli ali oboje (glejte Opozorila in previdnostni ukrepi in poglavje 4.
English: Therefore if clinical features of TMA are observed, further testing of blood platelet levels, serum LDH, blood films and renal function is recommended.
Slovenian: Če so opaženi klinični znaki TMA, se priporočajo nadaljnje preiskave za določitev koncentracije trombocitov v krvi, LDH v serumu, pregled krvnih razmazov in preiskave delovanja ledvic.
English: However, it is known that the biologic response-modifying properties of interferon beta-1b are mediated through its interactions with specific cell receptors found on the surface of human cells.
Slovenian: 1b, ki spreminjajo biološki odziv, posredujejo prek njegovih interakcij s specifičnimi celičnimi receptorji na površini humanih celic.
English: There are sparse and inconclusive data on patients who have developed neutralising activity and have completed Betaferon therapy.
Slovenian: Podatkov o bolnikih, pri katerih se je razvila nevtralizacijska aktivnost in so dokončali zdravljenje z zdravilom Betaferon, je malo in so neprepričljivi.
English: Keep the syringe in a horizontal position and the vial below the syringe.
Slovenian: Brizga naj bo v vodoravnem položaju, viala pa pod njo.
English: 4.7 Effects on ability to drive and use machines
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja strojev Študij o vplivu na sposobnost vožnje in upravljanja strojev niso izvedli.
English: Betaferon may cause serious side effects.
Slovenian: Zdravilo Betaferon lahko povzroči tudi resne neželene učinke.
English: Doing this allows the solution to flow down into the syringe.
Slovenian: Tako bo raztopina lahko stekla v brizgo.
English: − If you have loss of appetite, fatigue, feeling sick (nausea), repeated vomiting, especially if you notice widespread itching, yellowing of the skin or of the whites of the eyes, or easy bruising.
Slovenian: - če izgubite apetit, ste utrujeni, vam je slabo (navzea), se pojavi ponavljajoče bruhanje, predvsem, če opazite srbenje po vsem telesu, rumeno obarvanje kože in očesnih beločnic ter nagnjenost k podplutbam.
English: Events were reported at various time points during treatment and may occur after several years of treatment with interferon beta.
Slovenian: O dogodkih so poročali v različnih obdobjih zdravljenja in se lahko pojavijo po več letih zdravljenja z interferonom beta.
English: Fever Λ * °
Slovenian: Λ * °
English: No formal interaction studies have been carried out to find out whether Betaferon affects other medicines or is affected by them.
Slovenian: Študij medsebojnega delovanja, s katerimi bi ugotovili vpliv zdravila Betaferon na druga zdravila, niso izvedli.
English: Side effects derived only during post-marketing:
Slovenian: Neželeni učinki, o katerih so poročali samo v obdobju trženja
English: The most appropriate MedDRA term is used to describe a certain reaction and its synonyms and related conditions.
Slovenian: Za opis neke reakcije in njenih sinonimov ter povezanih stanj je uporabljen najprimernejši izraz po klasifikaciji MedDRA.
English: This data suggests that the safety profile from this age is the same as in adults for use of Betaferon 8.0 million IU under the skin every other day.
Slovenian: Ti podatki kažejo, da je varnostni profil za to starost enak kot za odrasle, ki uporabljajo zdravilo Betaferon 8,0 milijonov i.e. podkožno vsak drugi dan. Ni informacij o uporabi zdravila Betaferon pri otrocih, starih manj kot 12 let.
English: − if you get some or all of these symptoms: foamy urine, fatigue, swelling, particularly in the ankles and eyelids, and weight gain, as they may be signs of a possible kidney problem.
Slovenian: ► Takoj obvestite zdravnika: - če se vam pojavijo nekateri ali vsi od naštetih simptomov: penast urin, utrujenost, otekanje, zlasti gležnjev in vek, povečanje telesne mase, saj so to lahko znaki možne ledvične bolezni.
English: After mixing Betaferon, you should give the injection immediately (if Betaferon is not used immediately, see section 5.
Slovenian: Ko pripravite zdravilo Betaferon, si ga morate takoj injicirati (če zdravila Betaferon ne uporabite takoj, glejte poglavje 5, Shranjevanje zdravila Betaferon v prvem delu tega navodila za uporabo).
English: No benefit, attributable to immediate Betaferon treatment, in quality of life (as measured by FAMS - Functional Assessment of MS: Treatment Outcomes Index) was seen.
Slovenian: Koristi za kakovost življenja (merjenih po FAMS - Functional Assessment of MS:
English: Cessation of therapy with Betaferon should be considered (see also sections 4.3 and
Slovenian: Treba je razmisliti o prenehanju zdravljenja z zdravilom Betaferon (glejte tudi poglavji 4.3 in 4.8).
English: Betaferon is a sterile white to off-white powder for solution for injection.
Slovenian: Zdravilo Betaferon je sterilen bel do belkast prašek za raztopino za injiciranje.
English: This last triple pack should be used for treatment days 19, 21 and 23.
Slovenian: To zadnje tridelno pakiranje je namenjeno za uporabo 19., 21. in 23. dan zdravljenja.
English: Remove the vial with the vial adapter from the pre-filled syringe before injection.
Slovenian: Viale z adapterjem pred injiciranjem odstranite z napolnjene injekcijske brizge.
English: For details how the Betaferon solution for injection is prepared see Annex ‘Self-injection procedure', Part I.
Slovenian: Glede podrobnejših navodil o uporabi raztopine za injiciranje Betaferon glejte Dodatek: Postopek samoinjiciranja, del I.
English: Cases of pulmonary arterial hypertension (PAH) have been reported with interferon beta products.
Slovenian: Pri uporabi zdravil, ki vsebujejo interferon beta, so poročali o primerih pljučne arterijske hipertenzije (PAH).
English: − if you experience symptoms such as itching all over your body, swelling of your face and/or your tongue or sudden shortness of breath.
Slovenian: - če se pojavijo simptomi, kot je srbenje po vsem telesu, oteklost obraza in/ali jezika ali nenadna kratka sapa.
English: In the different controlled clinical trials in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis, between 23% and 41% of the patients developed serum interferon beta1b neutralising activity confirmed by at least two consecutive positive titres; of these patients, between 43% and 55% converted to a stable antibody negative status (based on two consecutive negative titres) during the subsequent observational period of the respective study.
Slovenian: V različnih nadzorovanih kliničnih preskušanjih pri bolnikih z recidivno-remitentno multiplo sklerozo in sekundarno progresivno multiplo sklerozo se je pri 23 do 41 % bolnikov pojavila nevtralizacijska aktivnost interferona beta-1b v serumu, ki so jo potrdili z vsaj dvema zaporednima pozitivnima titroma.
English: Instructions for keeping track of your injection sites and dates
Slovenian: Zapisovanje mest injiciranja in datumov
English: Year 3 results Open-label follow-up
Slovenian: Izsledki v tretjem letu odprtega nadaljevanja študije
English: • patients with secondary progressive multiple sclerosis with active disease, evidenced by relapses.
Slovenian: • bolnikov s sekundarno progresivno multiplo sklerozo (SP-MS), pri katerih je bolezen aktivna,
English: Part of a titration pack.
Slovenian: Del seta za titriranje.
English: Capillary leak syndrome in pre-existing monoclonal gammopathy2
Slovenian: Bolezni imunskega sistema anafilaktične reakcije sindrom kapilarne prepustnosti pri obstoječi monoklonalni gamopatiji2
English: The placebo-controlled phase lasted for 2 years or until the patient developed clinically definite multiple sclerosis (CDMS), whichever came first.
Slovenian: S placebom nadzorovano obdobje je trajalo 2 leti ali dokler se ni pri bolniku razvila klinično potrjena multipla skleroza
English: Interferon beta-1b has been given without serious adverse events compromising vital functions to adult cancer patients at individual doses as high as 5,500 microgram (176 million IU) intravenously three times a week.
Slovenian: Pri odraslih bolnikih z rakom, ki so prejemali interferon beta-1b v individualnih odmerkih do 5.500 mikrogramov (176 milijonov i.e.) intravensko trikrat na teden se niso pojavili neželeni učinki, ki bi ogrozili življensko pomembne funkcije.
English: Cases of thrombotic microangiopathy, manifested as thrombotic thrombocytopenic purpura (TTP) or haemolytic uraemic syndrome (HUS), including fatal cases, have been reported with interferon beta products.
Slovenian: Pri zdravilih z interferonom beta so poročali o primerih trombotične mikroangiopatije, ki se je izrazila kot trombotična trombocitopenična purpura (TTP) ali hemolitično-uremični sindrom (HUS), vključno s smrtnimi primeri.
English: ► Important tips to keep in mind
Slovenian: ► Pomembni napotki
English: RelapsingRemitting Multiple Sclerosis
Slovenian: recidivno remitentna multipla skleroza
English: Patients with monofocal or multifocal onset of the disease were included (i.e. patients with clinical evidence for a single or at least two lesions, respectively, of the central nervous system).
Slovenian: Vključili so bolnike z monofokalnim (bolnike s kliničnimi znaki ene lezije osrednjega živčevja) in multifokalnim (bolnike s kliničnimi znaki vsaj dveh lezij osrednjega živčevja) začetkom bolezni.
English: − During treatment with Betaferon, kidney problems that may reduce your kidney function, including scarring (glomerulosclerosis), may occur.
Slovenian: - Med zdravljenjem z zdravilom Betaferon, se lahko pojavijo težave z ledvicami, ki poslabšajo delovanje ledvic, tudi brazgotinjenje (glomeruloskleroza).
English: Table 2: Adverse drug reactions (ADRs) identified during post-marketing surveillance (frequencies where known - calculated based on pooled clinical trial data N= 1093)
Slovenian: Preglednica 2: Neželeni učinki zdravila iz spremljanj v obdobju trženja (pogostnosti - kjer so znaneizračunane glede na združene podatke iz kliničnih preskušanj n = 1.093)
English: In addition to those laboratory tests normally required for monitoring patients with multiple sclerosis, complete blood and differential white blood cell counts, platelet counts, and blood chemistries, including liver function tests (e.g. AST (SGOT), ALT (SGPT) and γ-GT), are recommended prior to initiation and at regular intervals following introduction of Betaferon therapy, and then periodically thereafter in the absence of clinical symptoms.
Slovenian: Poleg laboratorijskih preiskav, ki so običajne pri spremljanju bolnikov z multiplo sklerozo, se priporoča, da se pred začetkom zdravljenja z zdravilom Betaferon, v rednih presledkih po uvedbi zdravljenja in nato periodično, če ni kliničnih simptomov, naredi celotna krvna slika, diferencialna bela krvna slika, določi število trombocitov in opravi biokemične krvne preiskave, vključno s preiskavami delovanja jeter (npr. AST (SGOT), ALT (SGPT) in γ-GT).
English: Stopping Betaferon is not known to lead to acute withdrawal symptoms.
Slovenian: Če nehate uporabljati zdravilo Betaferon, ni pričakovati akutnih odtegnitvenih simptomov.
English: The active substance is interferon beta-1b, 250 microgram per millilitre when reconstituted.
Slovenian: Učinkovina je interferon beta-1b, 250 mikrogramov na mililiter po rekonstituciji.
English: Single clinical event indicating a high risk of developing multiple sclerosis: Betaferon has been shown to delay progression to definite multiple sclerosis.
Slovenian: Kako zdravilo Betaferon pomaga v boju proti bolezni Enkraten klinični dogodek, ki kaže na veliko tveganje za razvoj multiple skleroze: pokazali so, da zdravilo Betaferon upočasni napredovanje do dokončne multiple skleroze.
English: To reduce side effects at the start of treatment, your doctor should start you on a low dose of Betaferon and increase it gradually (see section 3.
Slovenian: Za zmanjšanje neželenih učinkov na začetku zdravljenja bo zdravnik začel z majhnim odmerkom zdravila Betaferon, ki ga bo postopoma povečeval (glejte poglavje 3, Kako uporabljati zdravilo Betaferon).
English: ‘How to use Betaferon' in the first part of this leaflet.
Slovenian: Kako uporabljati zdravilo Betaferon v prvem delu tega navodila za uporabo.
English: ► who have experienced symptoms for the first time which indicate a high risk of developing multiple sclerosis.
Slovenian: Zdravilo Betaferon je namenjeno za uporabo pri bolnikih ► ki so prvič imeli simptome, ki predstavljajo veliko tveganje za razvoj multiple skleroze.
English: B) Getting ready to inject C) Reconstituting the solution, step by step D) Drawing up the injection E) Making the injection F) Quick review of the process
Slovenian: C) Rekonstitucija raztopine po korakih D) Izvlek količine za injiciranje
English: Discard the vial with the remaining solution.
Slovenian: Viale z ostankom raztopine zavrzite.
English: 4th dosage step (1.0 ml) for treatment days 19, 21, 23
Slovenian: 4. korak odmerjanja (1,0 ml) za 19., 21. in 23. dan zdravljenja
English: Thyroid function tests are recommended regularly in patients with a history of thyroid dysfunction or as clinically indicated.
Slovenian: Laboratorijske preiskave Pri bolnikih z motnjami v delovanju ščitnice v anamnezi se priporoča redno opravljanje preiskav delovanja ščitnice oziroma kot je klinično indicirano.
English: The Betaferon powder is provided in a 3-millilitre vial, containing 300 microgram (9.6 million IU) interferon beta-1b per vial.
Slovenian: Prašek zdravila Betaferon je na voljo v 3-mililitrski viali, ki vsebuje 300 mikrogramov (9,6 milijonov i.e.) interferona beta-1b na vialo.
English: For skin disinfection use an appropriate disinfectant.
Slovenian: Za razkuževanje kože uporabite ustrezno razkužilo.
English: Betaferon microgram (Placebo) n=124 (n=123)
Slovenian: n = 124 (n = 123)
English: - the number of platelets (which help the blood to clot) may fall (thrombocytopenia) - a certain type of blood fats (triglycerides) may increase (will show up in blood tests), see section 2 ‘Warnings and precautions' - suicide attempt - mood swings - convulsion
Slovenian: - povečajo se lahko vrednosti določenih vrst maščob v krvi (trigliceridi) (to pokažejo krvne preiskave), glejte poglavje 2, Opozorila in previdnostni ukrepi - poskus samomora
English: ► If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Slovenian: ► Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Betaferon microgram (Placebo) n=360 (n=358)
Slovenian: n = 360 (n = 358)
English: Manufacturer Bayer AG
Slovenian: Bayer AG
English: 0.5 ml for the injections at day 7, 9 and 11 of therapy.
Slovenian: 0,5 ml za injiciranje na 7., 9. in 11. dan zdravljenja
English: Blood and lymphatic system disorders Lymphocyte count decreased (<1,500/mm³) ×
Slovenian: Bolezni krvi in limfatičnega sistema zmanjšano število limfocitov (< 1.500/mm³) × Λ °
English: It reduces the number of hospital stays due to the disease and prolongs the time without relapses.
Slovenian: Pokazali so, da zdravilo Betaferon zmanjša pogostnost in resnost zagonov, zmanjša število dni v bolnišnici zaradi bolezni in podaljša čas brez relapsov.
English: When starting treatment with Betaferon, it is tolerated best by gradually increasing the dose, i.e. starting with just 0.25 ml of the medication and then increasing, after every 3rd injection, first to 0.5 ml, then to 0.75 ml and then finally to the full dose (1 ml) of Betaferon.
Slovenian: Bolniki bolje prenašajo, če se na začetku zdravljenja z zdravilom Betaferon odmerek postopoma povečuje, tj. začne se samo z 0,25 ml zdravila in nato povečuje po vsaki tretji injekciji najprej do
English: 3 Vial adapters with needles + 6 alcohol wipes
Slovenian: III. 3 adapterji za viale z iglami + 6 alkoholnih blazinic
English: Your doctor has prescribed Betaferon to treat your MS. You will best tolerate Betaferon in the beginning if you start with a low dose and gradually increase to the full standard dose (see first part of the package leaflet, section 3.
Slovenian: Na začetku zdravljenja boste zdravilo Betaferon bolje prenašali, če boste zdravljenje začeli z manjšimi odmerki in jih postopoma povečevali do celotnega odmerka (glejte prvi del navodila, poglavje 3.
English: This will give each injection site a chance to fully recover before receiving another injection.
Slovenian: Tako si bo mesto injiciranja povsem opomoglo, preden ga boste ponovno uporabili za injiciranje.
English: Slowly pull the plunger back to withdraw all the solution out of the vial and into the syringe.
Slovenian: Bat počasi povlecite nazaj in vso raztopino iz viale izvlecite v brizgo.
English: This second triple pack should be used for treatment days 7, 9 and 11.
Slovenian: To drugo tridelno pakiranje je namenjeno za uporabo 7., 9. in 11. dan zdravljenja.
English: Betaferon 250 mcg n=292
Slovenian: Betaferon mikrogramov n = 292
English: Cases of nephrotic syndrome with different underlying nephropathies including collapsing focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranoproliferative glomerulonephritis (MPGN) and membranous glomerulopathy (MGN) have been reported during treatment with interferon beta products.
Slovenian: Nefrotski sindrom Med zdravljenjem z zdravili, ki vsebujejo interferon beta, so poročali o primerih nefrotskega sindroma pri različnih predhodnih nefropatijah, vključno s fokalno segmentno glomerulosklerozo (kolapsno spremenjeni glomeruli), glomerulonefritisom z minimalnimi spremembami, membranoproliferativnim glomerulonefritisom in membransko glomerulopatijo.
English: 6 - Inject the medicine using a slow, steady push on the plunger.
Slovenian: 6 - S počasnim, enakomernim potiskanjem na bat injicirajte zdravilo.
English: This may suggest an inflammation of the pancreas (pancreatitis), which has been reported with Betaferon use.
Slovenian: Morda to kaže na vnetje trebušne slinavke (pankreatitis), o katerem poročajo pri bolnikih, ki jemljejo zdravilo Betaferon.
English: Use red triple pack No. 2 for treatment days 7, 9 and 11
Slovenian: Uporabite rdeče tridelno pakiranje 2 za 7., 9. in 11. dan zdravljenja.
English: Advice on which areas to choose is given in the first part of this Annex.
Slovenian: Nasvet o predelih, primernih za injiciranje, je v prvem delu dodatka.
English: 0.75 ml for the injections at day 13, 15 and 17 of therapy.
Slovenian: 0,75 ml za injiciranje na 13., 15. in 17. dan zdravljenja
English: AREA 2
Slovenian: PRILOGA II
English: For instructions on reconstitution of the medicinal product before administration, see section 6.6.
Slovenian: Način uporabe subkutano injiciranje Za navodila glede rekonstitucije zdravila pred dajanjem glejte poglavje 6.6.
English: Finally, after finishing with the green pack, start using the blue triple pack which is clearly marked with a "4" on the top right hand side of the box.
Slovenian: Na koncu, po končani uporabi zelenega tridelnega pakiranja, začnite z uporabo modrega tridelnega pakiranja, ki je jasno označeno s številko »4« na zgornji strani škatle.
English: Serum samples in controlled clinical trials were collected every 3 months for monitoring of development of antibodies to Betaferon.
Slovenian: Za spremljanje nastanka protiteles proti zdravilu Betaferon so bolnikom v nadzorovanih kliničnih preskušanjih vsake 3 mesece odvzeli vzorce seruma.
English: Events were reported at various time points during treatment and may occur several weeks to several years after starting treatment with interferon beta.
Slovenian: O dogodkih so poročali v različnih obdobjih zdravljenja in se lahko pojavijo nekaj tednov do nekaj let po začetku zdravljenja z interferonom beta.