FrancophonIA/ELRC3.0 huggingface dataset:
English: Therefore, in order to provide the most comprehensive safety information, the analysis of ADRs presented in the following has been performed on the entire study population (i.e. iNHL).
Croatian: Stoga je, kako bi se dobile najobuhvatnije informacije o sigurnosti, analiza nuspojava na lijek navedenih u nastavku provedena u cjelokupnoj ispitivanoj populaciji (tj. u bolesnika s iNHL-om).
English: These events may occur as part of an IRR and can be fatal.
Croatian: Ti se događaji mogu pojaviti kao dio reakcije na infuziju i mogu biti smrtonosni.
English: Intravenous corticosteroid1,4
Croatian: Intravenski kortikosteroid1,4
English: Following intravenous administration, the volume of distribution of the central compartment (2.98 L in patients with CLL and 2.97 in patients with iNHL), approximates serum volume, which indicates distribution is largely restricted to plasma and interstitial fluid.
Croatian: Nakon intravenske primjene, volumen distribucije središnjeg odjeljka (2,98 l u bolesnika s KLL-om i 2,97 l u bolesnika s iNHL-om) bio je približno jednak volumenu seruma, što pokazuje da je distribucija uvelike ograničena na plazmu i intersticijsku tekućinu.
English: These can be complemented with other appropriate markers as per local guidelines.
Croatian: Testiranje se može dopuniti i određivanjem drugih odgovarajućih biljega, sukladno lokalnim smjernicama.
English: At a minimum this should include hepatitis B surface antigen (HBsAg) status and hepatitis B core antibody (HBcAb) status.
Croatian: Probir bi morao najmanje uključivati određivanje statusa površinskog antigena hepatitisa B (HBsAg) i statusa protutijela na sržni antigen hepatitisa B (HBcAb).
English: 1See section 5.1 for information on chlorambucil dose
Croatian: 1Vidjeti dio 5.1 za informacije o dozi klorambucila
English: Late onset neutropenia (occurring >28 days after the end of treatment) or prolonged neutropenia (lasting more than 28 days after treatment has been completed/stopped) may occur.
Croatian: Mogu se javiti odgođena neutropenija (koja se javlja ˃28 dana nakon završetka liječenja) ili dugotrajna neutropenija (koja traje dulje od 28 dana nakon završetka/prekida liječenja).
English: · Do not use this medicine after the expiry date which is stated on the carton after EXP.
Croatian: · Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake
English: The majority of patients had follicular lymphoma (81%).
Croatian: Većina bolesnika imala je folikularni limfom (81%).
English: followed by 48 hours (including infusion time) at ≤ 30°C.
Croatian: 2°C do 8°C, a nakon toga još 48 sati (uključujući vrijeme infuzije) na temperaturi ≤ 30°C.
English: Day 2 for CLL only
Croatian: 2. dan, samo kod KLL-a
English: Intravenous corticosteroid1 (mandatory)
Croatian: Intravenski kortikosteroid1 (obavezno)
English: Gazyvaro contains the active substance obinutuzumab, which belongs to a group of medicines called “monoclonal antibodies”.
Croatian: Gazyvaro sadrži djelatnu tvar obinutuzumab, koja pripada skupini lijekova koji se zovu ‘monoklonska protutijela'.
English: If the first bag is completed without modifications of the infusion rate or interruptions, the second bag may be administered on the same day (no dose delay necessary, no repetition of premedication), provided that appropriate time, conditions and medical supervision are available throughout the infusion.
Croatian: Ako primjena prve vrećice završi bez prilagodbe brzine infuzije ili prekida primjene, drugu je vrećicu moguće primijeniti istoga dana (nije potrebno odgađati primjenu lijeka niti ponovno primijeniti premedikaciju), pod uvjetom da za to ima dovoljno vremena te da postoje odgovarajući uvjeti i da se tijekom cijele infuzije može provoditi liječnički nadzor.
English: Consideration should be given to the need for regular monitoring of blood cell count and for increased risk of infections while patients are B-cell depleted.
Croatian: Treba razmotriti potrebu za redovitom kontrolom krvne slike i nadzorom zbog povećanog rizika od infekcije tijekom razdoblja u kojem bolesnici imaju depleciju B stanica.
English: No significant difference was observed in the pharmacokinetics of obinutuzumab among patients < 65 years (n=375), patients between 65-75 years (n=265) and patients > 75 years (n=171).
Croatian: Nije primijećena značajna razlika u farmakokinetici obinutuzumaba između bolesnika < 65 godina (n = 375), bolesnika u dobi između 65 i 75 godina (n = 265) i bolesnika
English: Hypersensitivity may be difficult to clinically distinguish from IRRs.
Croatian: Preosjetljivost može biti teško klinički razlikovati od reakcija na infuziju.
English: Obinutuzumab is not a substrate, inhibitor, or inducer of cytochrome P450 (CYP450), uridine diphosphate glucuronyltransferase (UGT) enzymes and transporters such as P-glycoprotein.
Croatian: Obinutuzumab nije supstrat, inhibitor niti induktor citokroma P450 (CYP450), enzima uridin difosfat glukuronoziltransferaze (UGT) niti prijenosnika poput P-glikoproteina.
English: In animal models obinutuzumab mediates potent B-cell depletion and antitumour efficacy.
Croatian: U životinjskim modelima obinutuzumab posreduje u snažnoj depleciji B-stanica i protutumorskoj djelotvornosti.
English: Obinutuzumab elimination comprises two parallel pathways which describe clearance, a linear clearance pathway and a non-linear clearance pathway which changes as a function of time.
Croatian: Eliminacija obinutuzumaba odvija se dvama paralelnim putovima koji opisuju klirens, linearni klirens i nelinearni klirens koji se mijenja kao funkcija vremena.
English: In addition these patients should be hydrated with caution in order to prevent a potential fluid overload.
Croatian: u tih je bolesnika potrebno hidraciju provoditi uz oprez kako bi se spriječilo moguće preopterećenje tekućinom.
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000
Croatian: Učestalost je definirana kao: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000
English: This subgroup comprised 21% (253/1202) of the FL ITT population and experienced 16.3% (40/245) of the PFS events.
Croatian: Tu je podskupinu činilo 21% (253/1202) populacije s FL-om predviđene za liječenje (engl. intent-to-treat, ITT) i u njoj je zabilježeno 16,3% (40/245) događaja PFS-a.
English: Cycle 1:
Croatian: 1. ciklus:
English: Do not increase the infusion rate.
Croatian: Brzinu infuzije ne smije se povećavati.
English: If treatment is necessary it should be administered in accordance with local guidelines and the administration of granulocyte-colony stimulating factors (G-CSF) should be considered.
Croatian: Ako je potrebno liječenje, ono mora biti provedeno sukladno lokalnim smjernicama, a potrebno je razmotriti i primjenu čimbenika poticanja rasta kolonija granulocita (engl. granulocyte-colony stimulating factors, G-CSF).
English: The incidence of thrombocytopenia was 14%.
Croatian: Incidencija trombocitopenije iznosila je 14%.
English: · A typical schedule is shown below.
Croatian: · Uobičajen raspored primjene prikazan je u nastavku.
English: The combination of obinutuzumab with chlorambucil, bendamustine, CHOP or CVP may increase the risk of neutropenia (see section 4.4).
Croatian: Kombinacija obinutuzumaba i klorambucila, bendamustina, protokola CHOP ili protokola CVP može povećati rizik od neutropenije (vidjeti dio 4.4).
English: Women of childbearing potential must use effective contraception during and for 18 months after treatment with Gazyvaro.
Croatian: Žene reproduktivne dobi moraju koristiti učinkovitu kontracepciju tijekom i 18 mjeseci nakon liječenja lijekom Gazyvaro.
English: All patients considered at risk should be carefully monitored during the initial days of treatment with a special focus on renal function, potassium, and uric acid values.
Croatian: Sve bolesnike koje se smatra rizičnima potrebno je pažljivo nadzirati tijekom prvih nekoliko dana liječenja, obraćajući posebnu pozornost na funkciju bubrega te vrijednosti kalija i mokraćne kiseline.
English: Gazyvaro should be prepared by a healthcare professional using aseptic technique.
Croatian: Upute za razrjeđivanje Gazyvaro mora pripremiti zdravstveni radnik primjenom aseptičke tehnike.
English: Required amount of Gazyvaro concentrate
Croatian: Potrebna količina koncentrata lijeka Gazyvaro
English: The following side effects have been reported with this medicine:
Croatian: Kod primjene ovog lijeka prijavljene su sljedeće nuspojave:
English: NR (25.4,-)
Croatian: ND (25,4;-)
English: · If you get an infusion related reaction, you may require additional treatment, or the infusion may need to be slowed down or stopped.
Croatian: · Ako se pojavi reakcija na infuziju, možda ćete trebati dodatno liječenje ili će trebati smanjiti brzinu infuzije ili prekinuti njezinu primjenu.
English: The observed HRs by chemotherapy subgroup were as follows; CHOP (n = 398): HR 0.77 (95% CI: 0.50, 1.20), CVP (n = 118): HR 0.63 (95% CI: 0.32, 1.21), and bendamustine (n = 686): HR 0.61 (95% CI: 0.43, 0.86).
Croatian: Opaženi omjeri hazarda prema kemoterapijskoj podskupini bili su sljedeći: CHOP (n = 398): HR 0,77 (95% CI: 0,50 - 1,20); CVP (n = 118): HR 0,63 (95% CI: 0,321,21); bendamustin (n = 686): HR 0,61 (95% CI: 0,43 - 0,86).
English: Day 2 (or Day 1 continued) (900 mg)
Croatian: 2. dan (ili nastavak 1. dana) (900 mg)
English: If you are not sure talk to your doctor or nurse before being given Gazyvaro.
Croatian: Ako niste sigurni, obratite se svom liječniku ili medicinskoj sestri prije nego primite Gazyvaro.
English: Do not use other diluents such as glucose (5%) solution (see section 6.2).
Croatian: Ne smijete koristiti druge otopine za razrjeđivanje poput otopine glukoze (5%) (vidjeti dio 6.2).
English: Gazyvaro binds to targets on the surface of the affected “B-lymphocyte” cells and causes them to die.
Croatian: Gazyvaro se veže za ciljna mjesta na površini stanica 'B limfocita' i uzrokuje njihovo odumiranje.
English: · The other ingredients are histidine, histidine hydrochloride monohydrate, trehalose dihydrate, poloxamer 188 and water for injections.
Croatian: · Drugi sastojci su histidin, histidinklorid hidrat, trehaloza dihidrat, poloksamer 188 i voda za injekcije.
English: Patients requiring premedication
Croatian: Bolesnici kojima je potrebna premedikacija Premedikacija
English: The median OS was not yet reached for either arm.
Croatian: Medijan OS-a nije dostignut ni u jednoj ni u drugoj skupini.
English: Transfusion of blood products (i.e. platelet transfusion) according to institutional practice is at the discretion of the treating physician.
Croatian: Transfuzija krvnih preparata (tj. transfuzija trombocita) sukladno praksi ustanove odluka je nadležnog liječnika.
English: Other medicines and Gazyvaro
Croatian: Drugi lijekovi i Gazyvaro
English: Patients who have pre-existing cardiac or pulmonary conditions should be monitored carefully throughout the infusion and the post-infusion period.
Croatian: Bolesnike s postojećim srčanim ili plućnim bolestima potrebno je pažljivo nadzirati tijekom cijele infuzije i u razdoblju nakon njezina završetka.
English: No specific studies in animals have been performed to evaluate the effect of obinutuzumab on fertility.
Croatian: Nisu provedena posebna ispitivanja na životinjama kojima bi se ocijenio učinak obinutuzumaba na plodnost.
English: The reduction in the risk of disease progression or death seen in the iNHL population is driven by the subset of patients with FL.
Croatian: Smanjenje rizika od progresije bolesti ili smrti primijećeno u populaciji bolesnika s iNHL-om temelji se na podskupini bolesnika s FL-om.
English: 539.3 μg/mL and AUC(τ) value was 10956 μg•day/mL.
Croatian: Cmax iznosio 539,3 μg/ml, a AUC(τ) 10 956 μg•d/ml.
English: Use of any concomitant therapies which could possibly worsen thrombocytopenia-related events, such as platelet inhibitors and anticoagulants, should also be taken into consideration, especially during the first cycle.
Croatian: Potrebno je voditi računa o istodobnoj primjeni bilo koje terapije koja bi mogla pogoršati događaje povezane s trombocitopenijom, poput inhibitora trombocita i antikoagulansa, osobito tijekom prvog ciklusa.
English: It specifically targets the extracellular loop of the CD20 transmembrane antigen on the surface of non-malignant and malignant pre-B and mature B-lymphocytes, but not on haematopoietic stem cells, pro-B-cells, normal plasma cells or other normal tissue.
Croatian: Djeluje ciljano na izvanstaničnu petlju transmembranskog antigena CD20 na površini nemalignih i malignih pre-B i zrelih B limfocita, ali ne i na hematopoetskim matičnim stanicama, pro-B stanicama, zdravim plazma stanicama ili drugom zdravom tkivu.
English: While fatal haemorrhagic events occurred in less than 1% of patients; none of the fatal adverse events occurred in Cycle 1.
Croatian: Događaji krvarenja sa smrtnim ishodom nastupili su u manje od 1% bolesnika, a niti jedan od štetnih događaja sa smrtnim ishodom nije zabilježen u 1. ciklusu.
English: 40 mL concentrate in a 50 mL vial (clear Type I glass) with stopper (butyl rubber).
Croatian: 40 ml koncentrata u bočici od 50 ml (bezbojno staklo tipa I) s čepom (butilna guma).
English: Do not use other diluents such as glucose (5%) solution.
Croatian: Ne smijete koristiti druge otopine za razrjeđivanje poput otopine glukoze (5%).
English: · fluids · medicines to reduce a fever · medicines to reduce pain (analgesics) · medicines to reduce inflammation (corticosteroids) · medicines to reduce an allergic reaction (anti-histamines)
Croatian: · lijekove koji ublažavaju upalu (kortikosteroide) · lijekove koji ublažavaju alergijsku reakciju (antihistaminike)
English: The bag should be gently inverted to mix the solution in order to avoid excessive foaming.
Croatian: Da biste pomiješali otopinu, vrećicu treba nježno preokrenuti kako bi se izbjeglo prekomjerno pjenjenje.
English: In the QLQC30 and QLQ-CLL-16 questionnaires conducted during the treatment period, no substantial difference in any of the subscales was observed.
Croatian: U upitnicima QLQC30 i QLQ-CLL-16, na koje su bolesnici odgovarali tijekom razdoblja liječenja, nisu primijećene značajne razlike niti na jednoj podljestvici.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Gazyvaro in all subsets of the paediatric population in CLLand FL (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Gazyvaro u svim podskupinama pedijatrijske populacije u liječenju KLL-a i FL-a (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: *pre-specified analyses performed on the intent to treat (ITT) population were repeated on the FL population; analysis of double refractory (i.e. unresponsive to or disease progression during or within 6 months of the last dose of an alkylating agent-based regimen) status was exploratory.
Croatian: *Unaprijed specificirane analize provedene u ITT populaciji ponovljene su i u populaciji oboljelih od FL-a; analiza dvostruko refraktornog statusa (tj. izostanak odgovora na liječenje ili progresija bolesti tijekom liječenja ili unutar 6 mjeseci nakon primjene posljednje doze protokola utemeljenog na alkilirajućem lijeku) bila je eksploracijska.
English: For each subsequent treatment cycle (Cycles 2 to 6), patients received Gazyvaro 1,000 mg on Day 1 only.
Croatian: U svakom sljedećem ciklusu liječenja (2.-6. ciklus), bolesnici su primili 1000 mg lijeka Gazyvaro samo 1. dan.
English: The incidence and severity of infusion related symptoms decreased substantially after the first 1,000 mg was infused, with most patients having no IRRs during subsequent administrations of Gazyvaro (see section 4.8).
Croatian: Incidencija i težina simptoma reakcija na infuziju bile su značajno manje nakon infuzije prvih 1000 mg, pa većina bolesnika nije imala reakcije na infuziju tijekom sljedećih primjena lijeka Gazyvaro (vidjeti dio 4.8).
English: The demographic data and baseline characteristics were well balanced between the treatment arms (median age 63 years, the majority were Caucasian [88%] and male [58%]).
Croatian: Demografski podaci i početne značajke bili su dobro ujednačeni u svim liječenim skupinama (medijan dobi iznosio je 63 godine, većina bolesnika bili su bijelci [88%] i muškarci [58%]).
English: The planned treatment interval for Gazyvaro should be maintained between doses.
Croatian: Potrebno je održavati planirani interval liječenja između pojedinih doza lijeka Gazyvaro.
English: All subsequent infusions for CLL and FL
Croatian: Sve sljedeće infuzije, kod KLL-a i FL-a
English: The primary analysis based on independent Review Committee (IRC) assessment demonstrated a statistically significant - 45% reduction in the risk of disease progression or death, in patients with iNHL receiving G+B followed by Gazyvaro maintenance, compared with patients receiving bendamustine alone.
Croatian: Primarna analiza utemeljena na ocjenama neovisnog ocjenjivačkog povjerenstva pokazala je statistički značajno smanjenje rizika od progresije bolesti ili smrti za 45% u bolesnika s iNHL-om liječenih kombinacijom G+B, nakon koje je uslijedila terapija održavanja lijekom Gazyvaro, u odnosu na bolesnike koji su primali samo bendamustin.
English: Size of PVC or non-PVC polyolefin infusion bag
Croatian: Veličina infuzijske vrećice od PVC-a ili vrećice od poliolefina koja ne sadrži PVC
English: A typical schedule is shown below.
Croatian: Uobičajen raspored primjene prikazan je u nastavku.
English: EQ-5D utility scores were similar at baseline, during treatment and follow-up.
Croatian: Rezultati za korisnost prema upitniku EQ-5D bili su slični na početku ispitivanja, tijekom liječenja i tijekom praćenja.
English: They will help you weigh up the benefit of continuing Gazyvaro against the risk to your baby.
Croatian: Oni će Vam pomoći da odvagnete koristi nastavka liječenja lijekom Gazyvaro u odnosu na rizike za dijete
English: · Tell your doctor or nurse straight away if you get any signs of infection after your Gazyvaro treatment (see "Infections" in section 4).
Croatian: · Odmah obavijestite svog liječnika ili medicinsku sestru ako nakon liječenja lijekom Gazyvaro primijetite bilo koji znak infekcije (pogledajte odlomak 'Infekcije' u dijelu 4.).
English: Forty-two percent of patients enrolled had both a CrCl < 70 mL/min and a comorbidity score of > 6.
Croatian: Četrdeset i dva posto bolesnika uključenih u ispitivanje imalo je i CrCl < 70 ml/min i rezultat bodovanja komorbiditeta > 6.
English: Corticosteroid premedication is recommended for patients with FL and mandatory for CLL patients in the first cycle (see Table 1).
Croatian: Premedikacija kortikosteroidima preporučuje se za bolesnike s FL-om, a obavezna je za bolesnike s KLL-om u prvom ciklusu liječenja (vidjeti Tablicu 1).
English: Administer at 25 mg/hr over 4 hours.
Croatian: Primijeniti brzinom od 25 mg/h tijekom 4 sata.
English: Patients with an IRR (Grade 1 or 2) with the previous infusion
Croatian: Bolesnici s reakcijom na infuziju (1. ili 2. stupnja) kod prethodne infuzije
English: Some signs/symptoms regarded as “cortical” (e.g. aphasia or visual-spatial disorientation) may occur.
Croatian: Mogu se javiti neki znakovi/simptomi koji se smatraju 'kortikalnima' (npr. afazija ili vidno-prostorna dezorijentacija).
English: · If you do have an infusion related reaction following the small part of your first dose, you will be given the rest of your first dose on Day 2.
Croatian: · Ako se nakon primjene malog dijela prve doze pojavi reakcija na infuziju, ostatak prve doze primit ćete 2. dana.
English: Chronic lymphocytic leukaemia · You will be given 6 treatment cycles of Gazyvaro in combination with another medicine for cancer called chlorambucil.
Croatian: Kronična limfocitna leukemija · Primit ćete 6 ciklusa liječenja lijekom Gazyvaro u kombinaciji s još jednim lijekom za liječenje raka, koji se zove klorambucil.
English: Animal studies have shown secretion of obinutuzumab in breast milk (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su da se obinutuzumab izlučuje u majčino mlijeko (vidjeti dio 5.3).
English: R-Chemo: Rituximab plus chemotherapy, G-Chemo: Gazyvaro plus chemotherapy, HR: hazard ratio, CI: confidence interval
Croatian: R-kemoterapija: rituksimab plus kemoterapija, G-kemoterapija: Gazyvaro plus kemoterapija, HR: omjer hazarda, CI: interval pouzdanosti
English: Based on the FACT-Lym questionnaire and EQ-5D index scale collected during the treatment and during follow-up periods, health-related quality of life was generally maintained in the pivotal study with no meaningful difference between the arms.
Croatian: Na temelju upitnika FACT -Lym i rezultata na ocjenskoj ljestvici iz upitnika EQ-5D tijekom razdoblja liječenja i praćenja, utvrđeno je da se kvaliteta života vezana uz zdravlje načelno održala u ključnom ispitivanju, bez značajne razlike između skupina.
English: In patients treated with G+ B, 79.4% received all six treatment cycles compared to 66.7% of patients in the B arm.
Croatian: Svih šest ciklusa liječenja primilo je 79,4% bolesnika liječenih kombinacijom G+B, u usporedbi sa 66,7%
English: You must not be given Gazyvaro if:
Croatian: Nemojte primiti Gazyvaro:
English: · Before each infusion of Gazyvaro, you will be given medicines which help to reduce possible infusion related reactions or “tumour lysis syndrome”.
Croatian: · Prije svake infuzije lijeka Gazyvaro primit ćete lijekove koji će pomoći ublažiti moguće reakcije na infuziju ili takozvani 'sindrom lize tumora'.
English: Duration of treatment Six treatment cycles, each of 28 day duration.
Croatian: Trajanje liječenja Šest ciklusa liječenja, od kojih svaki traje 28 dana.
English: The demographics data and baseline characteristics were well balanced between the treatment arms.
Croatian: Demografski podaci i početne značajke bili su dobro ujednačeni u svim liječenim skupinama.
English: Of these patients, none experienced anaphylactic or hypersensitivity reactions that were considered related to ATA, nor was clinical response affected.
Croatian: Niti jedan od tih bolesnika nije imao anafilaktičku reakciju ni reakciju preosjetljivosti koja bi se smatrala povezanom s protutijelima na lijek, niti su protutijela na lijek utjecala na klinički odgovor.
English: Gazyvaro is used together with another medicine for cancer called chlorambucil.
Croatian: - Gazyvaro se koristi zajedno s još jednim lijekom za liječenje raka, koji se zove klorambucil.
English: The safety and efficacy of Gazyvaro in patients with impaired hepatic function has not been established.
Croatian: Sigurnost i djelotvornost lijeka Gazyvaro u bolesnika s oštećenjem funkcije jetre nisu ustanovljene.
English: In the majority of patients, irrespective of indication, IRRs were mild to moderate and could be managed by the slowing or temporary halting of the first infusion, but severe and life-threatening IRRs requiring symptomatic treatment have also been reported.
Croatian: U većine su bolesnika, neovisno o indikaciji, reakcije na infuziju bile blage do umjerene te ih je bilo moguće zbrinuti usporavanjem ili privremenim prekidom prve infuzije, no prijavljene su i teške te po život opasne reakcije na infuziju koje su zahtijevale simptomatsko liječenje.
English: Progressive multifocal leukoencephalopathy (also called “PML”)
Croatian: Progresivna multifokalna leukoencefalopatija (koja se još zove i 'PML')
English: In case of exposure during pregnancy, depletion of B-cells may be expected in infants due to the pharmacological properties of the product.
Croatian: U slučaju izloženosti tijekom trudnoće, u dojenčadi se zbog farmakoloških značajki lijeka može očekivati deplecija B stanica.
English: Evaluation of PML includes, but is not limited to, consultation with a neurologist, brain magnetic resonance imaging (MRI), and lumbar puncture (cerebrospinal fluid testing for John Cunningham viral DNA).
Croatian: Procjena PML-a uključuje, između ostaloga, konzultaciju s neurologom, oslikavanje mozga magnetskom rezonancijom (MR) i lumbalnu punkciju (testiranje cerebrospinalnog likvora na prisutnost DNK John Cunningham virusa).