FrancophonIA/ELRC3.0 huggingface dataset:
English: In a drug interaction study, administration of Intuniv in combination with lisdexamfetamine dimesylate induced a 19% increase in guanfacine maximum plasma concentrations, whereas exposure (AUC) was increased by 7%.
Slovenian: V študiji interakcij med zdravili je dajanje zdravila Intuniv v kombinaciji z lisdeksamfetaminijevim dimesilatom povzročilo 19-odstotno zvečanje največjih koncentracij gvanfacina v plazmi, medtem ko se je izpostavljenost (AUC) zvečala za 7 %.
English: The tablets come in pack sizes of 7, 28 or 84 but not all pack sizes may be available.
Slovenian: Tablete so na voljo v pakiranjih po 7, 28 ali 84, vendar na trgu morda ni vseh navedenih pakiranj.
English: A decision must be made whether to discontinue breast-feeding or to discontinue and/or abstain from Intuniv therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba med prenehanjem dojenja in prenehanjem/prekinitvijo zdravljenja z zdravilom Intuniv, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
English: Adult patients Intuniv has not been studied in adults with ADHD.
Slovenian: Odrasli bolniki Zdravila Intuniv pri odraslih z ADHD niso proučevali.
English: The following effects may happen: low or high blood pressure, slow heart rate, slow breathing rate, feeling tired or exhausted.
Slovenian: Lahko boste opazili naslednje učinke: znižan ali zvišan krvni tlak, upočasnjen srčni utrip, upočasnjeno frekvenco dihanja, občutek utrujenosti ali izčrpanosti.
English: Immediate-release guanfacine tablets should not be substituted on a mg/mg basis, because of differing pharmacokinetic profiles.
Slovenian: Prehod z drugih farmacevtskih oblik gvanfacina Tablet gvanfacina s takojšnjim sproščanjem ne smemo zamenjati s tabletami s podaljšanim sproščanjem na podlagi mg/mg zaradi različnih farmakokinetičnih profilov.
English: Metabolism and nutrition disorders Decreased appetite
Slovenian: Presnovne in prehranske motnje zmanjšan apetit pogosti
English: Available pharmacodynamic and toxicological data in animals have shown excretion of guanfacine and its metabolites in milk (see section 5.3).
Slovenian: Razpoložljivi farmakodinamični in toksikološki podatki pri živalih kažejo na izločanje gvanfacina in njegovih presnovkov v mleko (glejte poglavje 5.3).
English: N Baseline ADHD-RS-IV (SD)
Slovenian: ADHD-RSIV (SD)
English: • need to urinate frequently (pollakiuria)
Slovenian: • potreba po pogostem uriniranju (polakisurija),
English: • Checklist for discontinuation of guanfacine including monitoring blood pressure and pulse of patients during downward titration.
Slovenian: • kontrolni seznam za prekinitev zdravljenja z gvanfacinom, vključno s spremljanjem krvnega tlaka in srčnega utripa bolnikov med zmanjševanjem odmerka.
English: • Information on the risks associated with Intuniv: Bradycardia, Syncope, Hypotension/decreased blood pressure, withdrawal blood pressure increase, sedative events and weight increase
Slovenian: • informacije o tveganjih, povezanih z zdravilom Intuniv: bradikardija, sinkopa, hipotenzija/znižan krvni tlak, zvišanje krvnega tlaka ob odtegnitvi zdravila, sedacijski dogodki in zvečanje telesne mase;
English: Somnolence/sedation, hypotension, bradycardia and syncope In the overall pool of guanfacine-treated patients, somnolence occurred in 40.6% and sedation in 10.2% of guanfacine-treated patients.
Slovenian: Somnolenca /sedacija, hipotenzija, bradikardija in sinkopa V celotni združeni skupini bolnikov, zdravljenih z gvanfacinom, se je somnolenca pojavila pri 40,6 % in sedacija pri 10,2 % bolnikov, zdravljenih z gvanfacinom.
English: Depending on the patient's response and tolerability for Intuniv the recommended maintenance dose range is 0.05-0.12 mg/kg/day.
Slovenian: Odvisno od bolnikovega odziva na zdravilo in prenašanja zdravila Intuniv je razpon priporočenih vzdrževalnih odmerkov 0,05-0,12 mg/kg/dan.
English: Based on in vitro studies, guanfacine is a substrate of OCT1 and OCT2, but not BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1 or MATE2.
Slovenian: Na podlagi študij in vitro je gvanfacin substrat OCT1 in OCT2, vendar ne BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1 ali MATE2.
English: The recommended dose is between 0.05 up to 0.12 mg per kg of bodyweight per day.
Slovenian: Priporočeni odmerek je med 0,05 in 0,12 mg na kg telesne mase na dan.
English: Intuniv should not be crushed, chewed or broken before swallowing because this increases the rate of guanfacine release.
Slovenian: Zdravila Intuniv ne smemo zdrobiti, žvečiti ali prelomiti, ker bi to zvečalo hitrost sproščanja gvanfacina.
English: • medicines that lower your blood pressure (antihypertensives)
Slovenian: • zdravila, ki znižujejo krvni tlak (antihipertenzivi);
English: Preclinical research suggests guanfacine modulates signalling in the prefrontal cortex and basal ganglia through direct modification of synaptic noradrenalin transmission at the alpha 2- adrenergic receptors.
Slovenian: Predklinične raziskave kažejo, da gvanfacin modulira pošiljanje signalov v prefrontalnem korteksu in bazalnih ganglijih z neposrednim modificiranjem sinaptičnega noradrenalinskega prenosa na adrenergičnih receptorjih alfa2A.
English: A significant increase in incidence of adenomas of the pancreatic islet was observed in male rats treated with 5 mg/kg/day guanfacine for 102 weeks but not in female rats.
Slovenian: Signifikanten porast incidence adenomov pankreatičnih otočkov so opazili pri samcih podgan, ki so jim dajali gvanfacin v odmerku 5 mg/kg/dan 102 tedna dolgo, ne pa pri samicah podgan.
English: • lack of energy (lethargy)
Slovenian: • pomanjkanje energije (letargija),
English: Paediatric patients (children and adolescents 6-17 years old inclusive) who develop lethargy should be observed for the development of more serious toxicity including coma, bradycardia, and hypotension for up to 24 hours, due to the possibility of delayed onset of these symptoms.
Slovenian: Pediatrične bolnike (otroke in mladostnike, stare 6 do vključno17 let), pri katerih se razvije letargija, je treba opazovati do 24 ur dolgo glede razvoja znakov resnejše toksičnosti, vključno s komo, bradikardijo in hipotenzijo, ker obstaja možnost odloženega nastopa teh simptomov.
English: Intuniv can be administered with or without food but should not be administered with high fat meals, due to increased exposure (see section 5.2).
Slovenian: Zdravilo Intuniv se lahko jemlje s hrano ali brez nje, ne sme pa se jemati z obroki zelo mastne hrane, ker bi to zvečalo izpostavljenost zdravilu (glejte poglavje 5.2).
English: Co-administration with Psychostimulants
Slovenian: Sočasno dajanje s psihostimulanti
English: By stimulating alpha 2A-adrenergic receptors, guanfacine reduces sympathetic nerve impulses from the vasomotor centre to the heart and blood vessels.
Slovenian: Gvanfacin s stimulacijo adrenergičnih receptorjev alfa2A zmanjšuje simpatične živčne impulze iz vazomotoričnega centra v srce in krvne žile.
English: This medicine is used to treat ‘attention deficit hyperactivity disorder' (ADHD) in children and adolescents 6-17 years old for whom current stimulant medication is not appropriate and/or current medication does not adequately control ADHD symptoms.
Slovenian: To zdravilo uporabljamo za zdravljenje ‘motnje pozornosti s hiperaktivnostjo' (ADHD- attention deficit hyperactivity disorder) pri otrocih in mladostnikih, starih 6-17 let, za katere trenutna spodbujevalna zdravila niso primerna in/ali trenutna zdravila simptomov ADHD ne obvladujejo ustrezno.
English: 6 monthly monitoring should follow thereafter, with more frequent monitoring following any dose adjustment.
Slovenian: Temu naj sledi spremljanje na 6 mesecev, po vsaki prilagoditvi odmerka pa naj bo spremljanje pogostnejše.
English: The peak plasma concentrations (Cmax) and exposure (AUC) of guanfacine decreased by 54% and 70% respectively.
Slovenian: Največje koncentracije gvanfacina v plazmi (Cmax) in izpostavljenost gvanfacinu (AUC) so se zmanjšale za 54 % oziroma 70 %.
English: • If you have missed two or more doses talk to your doctor as you may need to restart Intuniv with a lower dose.
Slovenian: • Če ste pozabili vzeti dva ali več odmerkov, se posvetujte z zdravnikom, saj se boste morda morali ponovno začeti zdraviti z manjšim odmerkom.
English: If you suddenly stop taking Intuniv, you may develop withdrawal symptoms of increased heart rate and high blood pressure (see section 4).
Slovenian: Če nenadoma prenehate jemati zdravilo Intuniv, se lahko pojavita odtegnitvena simptoma pospešitve srčnega utripa in visokega krvnega tlaka (glejte poglavje 4).
English: The effect of 2 dose levels of immediate-release guanfacine (4 mg and 8 mg) on QT interval was evaluated in a double-blind, randomised, placebo- and active-controlled, cross-over study in healthy adults.
Slovenian: Vpliv dveh ravni odmerkov gvanfacina s takojšnjim sproščanjem (4 mg in 8 mg) na interval QT so ocenjevali v dvojno slepi, randomizirani, s placebom in aktivno kontrolirani navzkrižni študiji pri zdravih odraslih.
English: • weight increase/risk of obesity
Slovenian: • zvečanja telesne mase /tveganja debelosti.
English: What Intuniv is and what it is used for
Slovenian: Kaj je zdravilo Intuniv in za kaj ga uporabljamo
English: Do not take Intuniv if:
Slovenian: Ne jemljite zdravila Intuniv:
English: The results showed that patients treated with add-on guanfacine improved more on the ADHD-RS-IV compared to those treated with add-on placebo (20.7 (12.6) points vs. 15.9 (11.8); difference: 4.9 95% CI 2.6 , 7.2).
Slovenian: Rezultati so pokazali, da so se bolniki, zdravljeni z dodanim gvanfacinom, na lestvici ADHD-RS-IV izboljšali bolj kot tisti, ki so prejemali dodan placebo (20,7 (12,6) točk proti 15,9 (11,8); razlika: 4,9 95 % CI 2,6, 7,2).
English: In human hepatic microsomes, guanfacine did not inhibit the activities of the other major cytochrome P450 isoenzymes (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 or CYP3A5); guanfacine is also not expected to be an inducer of CYP3A, CYP1A2 and CYP2B6.
Slovenian: V mikrosomih človeških jeter gvanfacin ni zaviral aktivnosti drugih pomembnih izoencimov s citokromom P450 (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 ali CYP3A5); za gvanfacin se tudi ne pričakuje, da bo induktor CYP3A, CYP1A2 in CYP2B6.
English: • Do not take grapefruit juice with this medicine as it can have an effect on the way this medicine works.
Slovenian: • Ne jemljite tega zdravila s sokom grenivke, ker sok grenivke lahko vpliva na način delovanja tega zdravila.
English: Guanfacine was not genotoxic in a variety of test models, including the Ames test and an in vitro chromosomal aberration test.
Slovenian: Gvanfacin v različnih preskusnih modelih, vključno z Amesovim testom in testom kromosomskih aberacij in vitro, ni bil genotoksičen.
English: Guanfacine was superior to placebo in the long-term maintenance of treatment in children and adolescents with ADHD as measured by cumulative treatment failures (49.3% for Intuniv, and 64.9% for placebo, p=0.006).
Slovenian: Gvanfacin je bil superioren v primerjavi s placebom pri dolgoročnem vzdrževalnem zdravljenju otrok in mladostnikov z ADHD, kar so izmerili s kumulativnimi neuspehi zdravljenja (49,3 % pri zdravilu Intuniv in 64,9 % pri placebu, p=0,006).
English: If somnolence and sedation are judged to be clinically concerning or persistent, a dose decrease or discontinuation should be considered.
Slovenian: Če sta somnolenca in sedacija klinično zaskrbljujoči ali trdovratni, bo mogoče treba odmerek zmanjšati ali zdravilo ukiniti.
English: Valproic acid
Slovenian: Valproična kislina
English: Intuniv should not be administered together with grapefruit juice (see section 4.5).
Slovenian: Zdravilo Intuniv se ne sme jemati skupaj s sokom grenivke (glejte poglavje 4.5).
English: Dose reduction may be required in patients with severe renal impairment (GFR 29-15 ml/min) and an end stage renal disease (GFR<15 ml/min) or requiring dialysis.
Slovenian: Pri bolnikih s težko okvaro jeter (GFR 29-15 ml/min) in z ledvično boleznijo v končnem stadiju (GFR<15 ml/min) in tistih, pri katerih je potrebna dializa, utegne biti potrebno zmanjšanje odmerka.
English: Intuniv is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents 6-17 years old for whom stimulants are not suitable, not tolerated or have been shown to be ineffective.
Slovenian: Zdravilo Intuniv je indicirano za zdravljenje motnje pozornosti s hiperaktivnostjo (ADHD- attention deficit hyperactivity disorder) pri otrocih in mladostnikih, starih 6 do 17 let, za katere stimulanti niso primerni, jih ne prenašajo ali so dokazali, da so neučinkoviti.
English: Uncommon: feeling faint or loss of conciousness (syncope).
Slovenian: Občasni: omedlevica ali izguba zavesti (sinkopa).
English: Do not stop taking Intuniv without talking to your doctor.
Slovenian: Ne prenehajte jemati zdravila Intuniv, ne da bi se posvetovali s svojim zdravnikom.
English: Furthermore, based on in vitro studies, guanfacine may be an inhibitor of OCT1 at maximal portal vein concentrations.
Slovenian: Poleg tega lahko na podlagi študij in vitro gvanfacin zavira OCT1 pri najvišjih koncentracijah v portalni veni.
English: There are no or limited amount of data from the use of guanfacine in pregnant women.
Slovenian: Podatkov o uporabi gvanfacina pri nosečnicah ni oziroma so omejeni.
English: Concomitant administration of guanfacine with MATE1 substrates may result in increases in the plasma concentrations of these medicinal products.
Slovenian: Sočasna uporaba gvanfacina s substrati MATE1 lahko povzroči zvišanje plazemskih koncentracij teh zdravil.
English: • Chart for ongoing monitoring (vital signs, height, weight) of patients during treatment with Intuniv.
Slovenian: • diagram za stalno spremljanje (vitalni znaki, telesna višina, telesna masa) bolnikov med zdravljenjemz zdravilom Intuniv;
English: The percentages of subjects who met response criteria (≥30% reduction from baseline in ADHD-RS-IV Total Score and a CGI-I value of 1 or 2) was 64.3% for guanfacine, 55.4% for atomoxetine and 42.3% for placebo.
Slovenian: Odstotni deleži preiskovancev, ki so izpolnjevali merila odziva ((≥30-odstotno zmanjšanje skupne ocene ADHD-RS-IV od izhodišča in vrednost CGI-I 1 ali 2), so bili 64,3 % za gvanfacin, 55,4 % za atomoksetin in 42,3 % za placebo.
English: What you need to know before you take Intuniv
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Intuniv
English: The major urinary metabolites were 3-hydroxy guanfacine glucuronide, guanfacine dihydrodiol, 3-hydroxy guanfacine sulphate.
Slovenian: Poglavitni presnovki v urinu so bili 3-hidroksi gvanfacinijev glukuronid, gvanfacinijev dihidrodiol in 3-hidroksi guanfacinijev sulfat.
English: The blister strips comprise of 2 layers, a clear thermoformable rigid film which is laminated with PCTFE to a PVC backing to which a push-through aluminium foil is adhered.
Slovenian: Dvojni trak pretisnega omota je sestavljen iz 2 plasti, prozorne termooblikovane toge folije, laminirane s PCTFE na PVC podlago, na katero je nalepljena aluminijasta folija za predrtje.
English: Guanfacine also showed significant improvement in learning, school and family functioning as measured with the (WFIRS-P score).
Slovenian: Gvanfacin je pokazal tudi značilno izboljšanje učenja in funkcioniranja v šoli in družini, merjeno z oceno WFIRS-P score.
English: Signs and symptoms of overdose may include hypotension, initial hypertension, bradycardia, lethargy, and respiratory depression.
Slovenian: Znaki in simptomi prevelikega odmerjanja lahko vključujejo hipotenzijo, začetno hipertenzijo, bradikardijo, letargijo in depresijo dihanja.
English: Intuniv can increase plasma concentrations of concomitantly administered medicinal products that are metabolised via CYP3A4/5 (see sections 4.2, 4.4 and 5.2).
Slovenian: Zdravilo Intuniv lahko zviša plazemske koncentracije sočasno dajanih zdravil, ki se presnavljajo preko CYP3A4/5 (glejte poglavja 4.2, 4.4 in 5.2).
English: The majority of patients achieved an optimised dose between 0.05-0.12mg/kg/day.
Slovenian: Večina bolnikov je dosegla optimiziran odmerek med 0,05 in 0,12 mg/kg/dan.
English: Do not chew, divide or crush.
Slovenian: Tablete ne smete žvečiti, razdeliti ali zdrobiti.
English: These effects occur predominantly at the start of treatment and may occur less frequently as treatment continues.
Slovenian: Ta učinka se pojavljata predvsem na začetku zdravljenja, z nadaljevanjem zdravljenja se lahko njuna pogostnost zmanjšuje.
English: Other medicines and Intuniv
Slovenian: Druga zdravila in zdravilo Intuniv
English: In the event of a missed dose, Intuniv dosing can resume the next day.
Slovenian: Če bolnik izpusti odmerek, se lahko odmerjanje zdravila Intuniv naslednjega dne nadaljuje.
English: If you take more Intuniv than you should
Slovenian: Če ste vzeli večji odmerek zdravila Intuniv, kot bi smeli
English: • To stop the medicine, your doctor will slowly reduce your Intuniv dose to minimise any side effects.
Slovenian: • Zdravnik vam bo ukinil zdravljenje z zdravilom Intuniv tako, da vam bo počasi zmanjševal odmerek zdravila, da se bodo morebitni neželeni učinki kar najbolj zmanjšali.
English: If the inducing treatment is ended, retitration to reduce the guanfacine dose is recommended during the following weeks (see section 4.5).
Slovenian: Če se zdravljenje s spodbujevalci konča, je v naslednjih tednih po tistem priporočljivo retitriranje za zmanjšanje odmerka gvanfacina (glejte poglavje 4.5).
English: The pharmacodynamic effect of Intuniv can have an additive effect when taken with other products known to cause sedation, hypotension or QT prolongation (see section 4.4).
Slovenian: Farmakodinamični učinek zdravila Intuniv ima lahko aditiven učinek, kadar ga bolnik jemlje z drugimi zdravili, za katera je znano, da povzročajo sedacijo, hipotenzijo ali podaljšanje intervala QT (glejte poglavje 4.4).
English: • Do not breast-feed while taking Intuniv unless told to do so by your doctor.
Slovenian: • Ne dojite, tačas ko jemljete zdravilo Intuniv, razen če vam to naroči zdravnik.
English: What Intuniv is and what it is used for What you need to know before you take Intuniv How to take Intuniv
Slovenian: Kaj je zdravilo Intuniv in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Intuniv Kako jemati zdravilo Intuniv Možni neželeni učinki
English: • Do not drink alcohol when taking this medicine as it may make you sleepy or drowsy.
Slovenian: • Kadar jemljete to zdravilo, ne uživajte alkohola, ker boste lahko zaradi njega postali zaspani ali se vam bo dremalo.
English: If you are worried, speak to your doctor.
Slovenian: Če vas ti učinki skrbijo, se pogovorite z zdravnikom.
English: In the data set from controlled, doubled blinded and open-label clinical studies with Intuniv the most frequently reported adverse reactions (very common) include somnolence (40.6%), headache (27.4%), fatigue (18.1%), abdominal pain upper (12.0%), and sedation (10.2%).
Slovenian: V skupini podatkov iz kontroliranih, dvojno slepih in odprtih kliničnih študij z zdravilom Intuniv neželeni učinki, o katerih najpogosteje poročajo (zelo pogosti), vključujejo somnolenco (40,6 %), glavobol (27,4 %), utrujenost (18,1 %), bolečine v zgornjem delu trebuha (12,0 %) in sedacijo (10,2 %).
English: Common: feeling drowsy (sedation), feeling dizzy (hypotension), slow heart beat (bradycardia).
Slovenian: Pogosti: dremavost (sedacija), občutek omotice (hipotenzija), upočasnjen srčni utrip (bradikardija).
English: Guanfacine is not an inhibitor of BSEP, MRP2, OATP1B1, OATP1B3, OAT1, OAT3, OCT2 or MATE2K, but it is an inhibitor of MATE1 and may be an inhibitor of OCT1 at maximal portal vein concentrations.
Slovenian: Gvanfacin ni zaviralec BSEP, MRP2, OATP1B1, OATP1B3, OAT1, OAT3, OCT2 ali MATE2K, vendar pa je zaviralec MATE1 in bi pri najvišjih koncentracijah v portalni veni lahko zaviral OCT1.
English: The major circulating metabolite is 3-OH-guanfacine sulphate which lacks pharmacological activity.
Slovenian: Najpomembnejši presnovek v krvi je 3-OH-gvanfacinijev sulfat, ki ni farmakološko aktiven.
English: Dose adjustments (increase or decrease) to a maximum tolerated dose within the recommended optimal weight-adjusted dose range based upon clinical judgement of response and tolerability may occur at any weekly interval after the initial dose.
Slovenian: Odmerek lahko prilagajate (zvečujete ali zmanjšujete) do največjega odmerka, ki ga bolnik prenaša, v okviru priporočenega optimalnega razpona odmerkov, prilagojenega telesni masi, na podlagi klinične presoje odziva in prenašanja, v katerem koli enotedenskem intervalu po začetnem odmerku.
English: Effects on height, weight and Body Mass index (BMI) Children and adolescents treated with Intuniv may show an increase in their BMI.
Slovenian: Učinki na telesno višino, telesno maso in indeks telesne mase (ITM) Otrokom in mladostnikom, ki se zdravijo z zdravilom Intuniv, se lahko zveča ITM.
English: Reproductive system and breast disorders Erectile dysfunction
Slovenian: Motnje reprodukcije in dojk erektilna disfunkcija neznana
English: Intuniv is not recommended during pregnancy and in women of childbearing potential not using contraception.
Slovenian: Zdravila Intuniv ne uporabljajte med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo učinkovite kontracepcije.
English: Caution is also advised when treating patients with Intuniv who are being treated concomitantly with antihypertensives or other medicinal products that can reduce blood pressure or heart rate or increase the risk of syncope.
Slovenian: Previdnost je priporočljiva tudi pri zdravljenju bolnikov, ki se sočasno zdravijo z antihipertenzivi ali drugimi zdravili, ki lahko znižujejo krvni tlak ali srčno frekvenco ali zvečajo nevarnost sinkope.
English: To minimise the risk of an increase in blood pressure upon discontinuation, the total daily dose of Intuniv should be tapered in decrements of no more than 1 mg every 3 to 7 days (see section 4.2).
Slovenian: Da bi zmanjšali tveganje za zvišanje krvnega tlaka ob prekinitvi zdravljenja, je treba celotni dnevni odmerek zdravila Intuniv postopoma zmanjševati za največ 1 mg na vsake 3 do 7 dni (glejte poglavje 4.2).
English: The effects of guanfacine in the treatment of ADHD has been examined in 5 controlled studies in children and adolescents (6 to 17 years), 3 short-term controlled trials in children and adolescents aged 6 to 17 years, 1 short-term controlled study in adolescents aged 13 to 17 years, and 1 randomised withdrawal trial in children and adolescents aged 6-17 years, all of whom met the DSM-IV-TR criteria for ADHD.
Slovenian: Učinke gvanfacina pri zdravljenju ADHD so raziskali v 5 kontroliranih študijah pri otrocih in mladostnikih (6 do 17 let), 3 kratkoročnih kontroliranih preskušanjih pri otrocih in mladostnikih, starih 6 do 17 let, 1 kratkoročni kontrolirani študiji pri mladostnikih, starih 13 do 17 let, in 1 preskušanju randomizirane odtegnitve pri otrocih in mladostnikih, starih 6 do 17 let, od katerih so vsi izpolnjevali merila DSM-IV-TR za ADHD.
English: Intuniv may affect your weight and height if taking for long periods, your doctor will therefore monitor your growth.
Slovenian: Če zdravilo Intuniv jemljete dolgo časa, lahko vpliva na vašo telesno maso in telesno višino, zato bo zdravnik spremljal vašo rast.
English: In a drug interaction study, neither Intuniv nor Osmotic Release Oral System (OROS)methylphenidate HCl extended-release were found to affect the pharmacokinetics of the other medicinal products when taken in combination.
Slovenian: V študiji interakcij med zdravili so ugotovili, da niti zdravilo Intuniv niti peroralni sistem za osmotsko sproščanje (OROS- Osmotic Release Oral System)-metilfenidat klorid s podaljšanim sproščanjem nista vplivala na farmakokinetiko drugih zdravil, kadar so ju jemali skupaj.
English: Pre-treatment screening:
Slovenian: Presejanje pred zdravljenjem: