FrancophonIA/ELRC3.0 huggingface dataset:
English: Febuxostat Krka is also used to treat and prevent high levels of uric acid in the blood in adults with blood cancers who are receiving chemotherapy (medicines to treat cancer) and at risk of tumour lysis syndrome (a complication due to the breakdown of cancer cells causing a sudden rise of uric acid in the blood which can cause damage to the kidneys).
Croatian: Krka također se primjenjuje za liječenje i sprečavanje visokih razina mokraćne kiseline u krvi u odraslih osoba s rakom krvi koje primaju kemoterapiju (lijekove protiv raka) te kod kojih postoji rizik od sindroma tumorske lize (komplikacija uslijed raspada stanica raka koja uzrokuje nagli porast mokraćne kiseline u krvi, što može uzrokovati oštećenje bubrega).
English: Why is Febuxostat Krka authorised in the EU?
Croatian: Zašto je lijek Febuxostat Krka odobren u EU-u?
English: Febuxostat Krka is a medicine used to treat adults with long-term hyperuricaemia (high levels of uric acid or ‘urate' in the blood).
Croatian: Krka lijek je koji se primjenjuje za liječenje odraslih s dugotrajnom hiperuricemijom (visoke razine mokraćne kiseline ili „urata” u krvi).
English: An overview of Febuxostat Krka and why it is authorised in the EU
Croatian: Pregled informacija o lijeku Febuxostat Krka i zašto je odobren u EU-u
English: Febuxostat Krka is available as tablets (80 and 120 mg) and can only be obtained with a prescription.
Croatian: Krka dostupan je u obliku tableta (80 i 120 mg) te se izdaje samo na liječnički recept.
English: As for every medicine, the company provided studies on the quality of Febuxostat Krka.
Croatian: Kao za svaki lijek, tvrtka je dostavila podatke o ispitivanjima kakvoće za lijek Febuxostat Krka.
English: What is Febuxostat Krka and what is it used for?
Croatian: Što je Febuxostat Krka i za što se primjenjuje?
English: As for all medicines, data on the use of Febuxostat Krka are continuously monitored.
Croatian: Kao za sve lijekove, podatci o primjeni lijeka Febuxostat Krka kontinuirano se prate.
English: Therefore, the Agency's view was that, as for Adenuric, the benefit of Febuxostat Krka outweighs the identified risk and it can be authorised for use in the EU.
Croatian: Stoga je stav Agencije da korist od lijeka Febuxostat Krka, kao i od lijeka Adenuric, nadmašuje identificirani rizik te da lijek može biti odobren za primjenu u EU-u.
English: Official address Domenico Scarlattilaan 6 ● 1083 HS Amsterdam ● The Netherlands
Croatian: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555
English: The active substance in Febuxostat Krka, febuxostat, reduces the formation of uric acid.
Croatian: Djelatna tvar lijeka Febuxostat Krka, febuksostat, smanjuje stvaranje mokraćne kiseline.
English: Other information about Febuxostat Krka
Croatian: Ostale informacije o lijeku Febuxostat Krka
English: How has Febuxostat Krka been studied?
Croatian: Kako je Febuxostat Krka ispitivan?
English: How is Febuxostat Krka used?
Croatian: Kako se Febuxostat Krka primjenjuje?
English: Febuxostat Krka contains the active substance febuxostat and is a ‘generic medicine'.
Croatian: Krka sadrži djelatnu tvar febuksostat te je „generički lijek”.
English: For example in the morning at breakfast, with lunch at mid-day and with dinner in the evening.
Croatian: Primjerice ujutro uz doručak, u podne uz ručak i navečer uz večeru.
English: Take the next dose at the usual time.
Croatian: Uzmite sljedeću dozu u uobičajeno vrijeme.
English: The registry should also be used to generate data on long-term effectiveness.
Croatian: Registar treba također koristiti za dobivanje podataka o dugoročnoj učinkovitosti.
English: - Take the tablets at the same time of day each day.
Croatian: - Uzimajte tablete u isto vrijeme svaki dan.
English: Date of first authorisation: 8 September 2015
Croatian: Datum prvog odobrenja: 8. rujna 2015
English: This may cause allergic reactions.
Croatian: Ovo bojilo može izazvati alergijske reakcije.
English: This medicinal product has been authorised under ‘exceptional circumstances'.
Croatian: Ovaj lijek je odobren u „iznimnim okolnostima“.
English: Currently available data are described in sections 5.1 and 5.2, but no recommendation on posology can be made.
Croatian: Trenutno dostupni podaci opisani su u dijelovima 5.1 i 5.2, međutim nije moguće dati preporuku o doziranju.
English: This can lead to some improvement in lost eyesight.
Croatian: To može rezultirati određenim poboljšanjem u izgubljenom vidu.
English: EAP and CRS
Croatian: EAP i CRS
English: When needed, supportive symptomatic treatment should be given.
Croatian: Kada je to potrebno, treba primijeniti potporno simptomatsko liječenje.
English: No data are available in these populations.
Croatian: Nema dostupnih podataka u ovim populacijama.
English: Always take this medicine exactly as your doctor or pharmacist has told you.
Croatian: Uvijek uzmite ovaj lijek točno onako kako vam je rekao Vaš liječnik ili ljekarnik.
English: Patients should be regularly monitored according to local clinical practice.
Croatian: Praćenje Bolesnike treba redovito pratiti u skladu s lokalnom kliničkom praksom.
English: - The active substance is idebenone.
Croatian: - Djelatna tvar je idebenon.
English: The recommended dose is 2 tablets three times a day - this is a total of 6 tablets per day.
Croatian: Preporučena doza je 2 tablete tri puta na dan - to znači ukupno 6 tableta na dan.
English: - Take the tablets with food - this helps to get more of the medicine from your stomach into your blood.
Croatian: - Uzmite tablete s hranom - to pomaže prijenosu više lijeka iz želuca u krv.
English: The safety of idebenone in pregnant women has not been established.
Croatian: Sigurnost primjene idebenona u trudnica nije utvrđena.
English: - Raxone is supplied in white plastic bottles.
Croatian: - Raxone se isporučuje u bijelim plastičnim bocama.
English: Exclusion of this patient yielded similar results as in the ITT population; as could be expected, the difference between idebenone and placebo arm was slightly larger.
Croatian: Isključenje ovog bolesnika imalo je za posljedicu slične rezultate kao i u ITT populaciji; kao što se moglo i očekivati, razlika između idebenona i placeba bila je neznatno veća.
English: However, the change in colour could mean that you have problems with your kidneys or bladder.
Croatian: No, promjena u boji može značiti da imate problema s bubrezima ili mjehurom.
English: There are no data concerning the effect of exposure to idebenone on human fertility.
Croatian: Ne postoje podaci o učincima izloženosti idebenonu na ljudsku plodnost.
English: Neither idebenone nor its metabolites showed time-dependent pharmacokinetics.
Croatian: Ni idebenon niti njegovi metaboliti nisu pokazali farmakokinetiku ovisnu o vremenu.
English: Other medicines and Raxone
Croatian: Drugi lijekovi i Raxone
English: The tablets should not be broken or chewed.
Croatian: Tablete se ne smiju lomiti niti žvakati.
English: If you take more Raxone than you should, talk to your doctor straight away.
Croatian: Ako uzmete više lijeka Raxone nego što biste trebali, odmah se obratite svom liječniku.
English: - Swallow the tablets whole with a glass of liquid.
Croatian: - Progutajte tablete cijele s čašom tekućine.
English: There is no specific antidote for idebenone.
Croatian: Ne postoji specifičan antidot za idebenon.
English: - LHON can lead to loss of eyesight due to the inactivity of cells responsible for vision.
Croatian: - LHON može rezultirati gubitkom vida uslijed neaktivnosti stanica odgovornih za vid.
English: Sunset yellow
Croatian: Boja sunset yellow
English: Contents of the pack and other information What Raxone contains
Croatian: Sadržaj pakiranja i druge informacije Što Raxone sadrži
English: Food increases the bioavailability of idebenone by approximately 5-7-fold and therefore, Raxone should always be administered with food.
Croatian: Hrana povećava bioraspoloživost idebenona za otprilike 5-7 puta te se stoga Raxone treba uvijek primjenjivati s hranom.
English: This means that due to the rarity of the disease it has not been possible to obtain complete information on this medicinal product.
Croatian: To znači da zbog male učestalosti ove bolesti nije bilo moguće dobiti potpune informacije o ovom lijeku.
English: Each bottle contains 180 tablets.
Croatian: Jedna boca sadrži 180 tableta.
English: This change in colour is harmless - it does not mean your treatment needs to change.
Croatian: Ova promjena u boji urina je bezopasna, tj. ne znači da morate promijeniti liječenje.
English: - He or she may do a urine check to make sure the change in colour is not hiding other problems.
Croatian: - Liječnik vam može napraviti pretragu urina kako bi bio siguran da promjena boje ne prikriva druge probleme.
English: Rash, pruritus
Croatian: Osip, pruritus
English: QS6+QS6 represented 6.45% to 9.46%, whereas QS10+QS10-C and IDE+IDE-C were close to 1% or below.
Croatian: QS6+QS6 činili su 6,45% do 9,46%, dok su QS10+QS10-C i IDE+IDE-C bili blizu 1% ili ispod.
English: Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity.
Croatian: Ispitivanja provedena u životinja ne ukazuju na izravan ili neizravan štetan učinak s obzirom na reproduktivnu toksičnost.
English: Patients received either 900 mg/day Raxone or placebo for a period of 24 weeks (6 months).
Croatian: Bolesnici su primili 900 mg/dan lijeka Raxone ili placebo tijekom razdoblja od 24 tjedna (6 mjeseci).
English: Reports to be provided at the time of annual re-assessment
Croatian: Izvještaje treba dostaviti u trenutku godišnje ponovne ocjene
English: What Raxone is and what it is used for
Croatian: Što je Raxone i za što se koristi
English: No specific dose adjustment is required for the treatment of LHON in elderly patients.
Croatian: Nije potrebno posebno prilagođavanje doze za liječenje LHON-a u starijih bolesnika.
English: Raxone should be administered with food because food increases the bioavailability of idebenone.
Croatian: Raxone treba uzimati s hranom budući da hrana povećava bioraspoloživost idebenona.
English: - It is caused by a problem with your genes (called a “genetic mutation”) that affects the ability of cells in the eye to produce the energy they need to work normally, so they become inactive.
Croatian: - Uzrokovan je problemom u genima ("genetskom mutacijom") koja utječe na sposobnost stanica u oku da proizvode energiju koja im je potrebna za normalni rad, tako da postaju neaktivne.
English: Idebenone is not a substrate for p-gp in vitro.
Croatian: Idebenon nije substrat za p-gp in vitro.
English: Idebenone should only be administered to pregnant women or women of child-bearing age likely to become pregnant if it is considered that the benefit of the therapeutic effect outweighs any potential risk.
Croatian: Idebenon se smije primjenjivati u trudnica ili žena reproduktivne dobi koje mogu zatrudnjeti samo ako se smatra da korist terapijskog djelovanja nadmašuje bilo kakav potencijalan rizik.
English: Experimental data have shown that idebenone passes the blood-brain barrier and is distributed at significant concentrations in cerebral tissue.
Croatian: Distribucija Eksperimentalni podaci pokazaju da idebenon prolazi barijeru krv-mozak i da se distribuira u značajnim koncentracijama u cerebralno tkivo.
English: Doses up to 2250 mg/day have been administered in clinical studies showing a safety profile consistent with that reported in section 4.8.
Croatian: Doze do 2250 mg/dan primijenjene su u kliničkim ispitivanjima, pokazujući sigurnosni profil koji je u skladu s profilom prijavljenim u dijelu 4.8.
English: Some medicine may interact with Raxone.
Croatian: Pojedini lijekovi mogu biti u interakciji s lijekom Raxone.
English: Your doctor will check your eye-sight before you start taking this medicine and then at regular visits while you are taking it.
Croatian: Liječnik će provjeriti Vaš vid prije nego počnete uzimati ovaj lijek te prilikom redovnih kontrola dok uzimate terapiju.
English: If you have been told by your doctor that you have lactose intolerance or that you cannot tolerate or digest some sugars, talk to your doctor before taking this medicine.
Croatian: Ako Vam je liječnik rekao da imate intoleranciju na laktozu ili da ne podnosite ili ne možete probaviti neke šećere, obratite se svom liječniku prije nego uzmete ovaj lijek.
English: Email: office@santhera.com
Croatian: E-pošta: office@santhera.com
English: The recommended dose is 900 mg/day idebenone (300 mg, 3 times a day).
Croatian: Preporučena doza iznosi 900 mg idebenona na dan (300 mg, 3 puta na dan).
English: Caution should be exercised to ensure that the chromaturia does not mask changes of colour due to other reasons (e.g. renal or blood disorders).
Croatian: Potreban je oprez kako bi se osiguralo da kromaturija ne zamaskira promjene boje nastale uslijed drugih razloga (primjerice poremećaja bubrega ili krvi).
English: Very common (may affect more than 1 in 10 people): - nasopharyngitis (cold) - cough
Croatian: Vrlo često (mogu se pojaviti u više od 1 na 10 osoba) - nazofaringitis (prehlada) - kašalj
English: The main metabolites in plasma are IDE-C and QS4+QS4-C.
Croatian: Glavni metaboliti u plazmi su IDE-C i QS4+QS4-C.
English: In phase I pharmacokinetic studies, proportional increases in plasma concentrations of idebenone were observed for doses from 150 mg to 1050 mg.
Croatian: U farmakokinetičkim ispitivanjima faze I, proporcionalna povećanja u koncentracijama idebenona u plazmi opažena su za doze od 150 mg do 1050 mg.
English: In this small subgroup of patients (n=8), 0 of 6 patients in the idebenone group deteriorated to ≥1.0 logMAR whereas 2 of 2 patients in the placebo group showed such a deterioration.
Croatian: U ovoj maloj podskupini bolesnika (n=8), 0 od 6 bolesnika u skupini koja je primala idebenon imalo je pogoršanje na ≥1,0 logMAR pri čemu su 2 od 2 bolesnika u skupini koja je primala placebo imala takvo pogoršanje.
English: If you forget a dose, skip the missed dose.
Croatian: Ako zaboravite uzeti dozu, preskočite propuštenu dozu.
English: If you are pregnant or breast-feeding, think you might be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: Therefore, a decision must be made whether to discontinue breast-feeding or to discontinue therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the mother.
Croatian: Stoga je nužno odlučiti treba li prekinuti dojenje ili prekinuti liječenje uzimajući u obzir korist dojenja za dijete i korist liječenja za majku.
English: This effect is harmless, not associated with haematuria, and does not require any adaptation of dose or discontinuation of treatment.
Croatian: Taj učinak je bezopasan i nije povezan s hematurijom, te ne zahtijeva prilagodbu doze niti prekid liječenja.
English: - Tell your doctor if your urine changes colour.
Croatian: - Obavijestite liječnika ako urin promijeni boju.
English: - Do not crush or chew the tablets.
Croatian: Ne drobite i ne žvačite tablete.
English: Studies in rats have shown that idebenone is excreted into maternal milk.
Croatian: Ispitivanja provedena u štakora pokazala su da se idebenon izlučuje u majčino mlijeko.
English: Raxone film-coated tablets should be swallowed whole with water.
Croatian: Raxone filmom obložene tablete treba progutati cijele s vodom.
English: Pharmacotherapeutic group: Psychoanaleptics, Other psychostimulants and nootropics; ATC code: N06BX13
Croatian: Farmakoterapijska skupina: Psihoanaleptici, Ostali psihostimulansi i nootropici; ATK oznaka: N06BX13
English: Treatment with Raxone can restore the ability of cells to produce energy and so allow inactive eye cells to work again.
Croatian: Liječenje lijekom Raxone može ponovno uspostaviti sposobnost stanica da proizvode energiju i tako omogućiti ponovno funkcioniranje neaktivnih stanica oka.
English: After a single or repeated oral dose of 750 mg Raxone, QS4+QS4-C were the most prominent idebenone-derived metabolites in urine, representing on average between 49.3% and 68.3% of the total administered dose.
Croatian: Nakon jednokratne ili ponovljene oralne doze od 750 mg lijeka Raxone, QS4+QS4-C bili su najzastupljeniji metaboliti idebenona u urinu, što predstavlja prosječno između 49,3% i 68,3% ukupno primijenjene doze.
English: Tests
Croatian: Testovi
English: No data regarding a continuous treatment with idebenone beyond 6 months is available from controlled clinical trials.
Croatian: Podaci vezani uz kontinuirano liječenje idebenonom dulje od 6 mjeseci iz kontroliranih kliničkih ispitivanja nisu dostupni.
English: - This eye problem is inherited - this means it runs in families.
Croatian: - Taj problem s okom je nasljedan - to znači da se prenosi s roditelja na djecu.
English: Interim reports should be provided at the time of annual reassessments.
Croatian: Privremeni izvještaji trebaju se dostaviti u trenutku godišnje ponovne ocjene.
English: What you need to know before you take Raxone 3.
Croatian: Što morate znati prije nego počnete uzimati Raxone
English: What Raxone looks like and contents of the pack
Croatian: Kako Raxone izgleda i sadržaj pakiranja
English: Clinical safety and efficacy of idebenone in LHON have been assessed in one double-blind, randomised, placebo-controlled study (RHODOS).
Croatian: Klinička sigurnost i djelotvornost idebenona u liječenju LHON-a ocijenjeni su u jednom dvostruko slijepom, randomiziranom, placebom kontroliranom ispitivanju (RHODOS).
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Raxone.
Croatian: Bolesnici s rijetkim nasljednim problemima nepodnošenja galaktoze, nedostatka Lapp laktaze ili malapsorpcije glukoze-galaktoze ne smiju uzimati Raxone.
English: Blood cholesterol increased, blood triglycerides increased
Croatian: Povišen kolesterol u krvi, povišeni trigliceridi u krvi
English: In RHODOS a total of 85 LHON patients, 14-66 years of age, with any of the 3 primary mtDNA mutations (G11778A, G3460A or T14484C) and disease duration of not more than 5 years were enrolled.
Croatian: U ispitivanje RHODOS bilo je uključeno ukupno 85 bolesnika s LHON-om, u dobi od 14 do 66 godina, s bilo kojom od 3 primarne mutacije mtDNK (G11778A, G3460A ili T14484C) i trajanjem bolesti ne duljim od 5 godina.
English: Raxone is not expected to affect your ability to drive or use machines.
Croatian: Ne očekuje se da će Raxone utjecati na Vašu sposobnost upravljanja vozilima i strojevima.
English: If you are breast-feeding your doctor will discuss with you whether to stop breast-feeding or to stop taking the medicine.
Croatian: Ako dojite Vaš će liječnik s vama raspraviti trebate li prekinuti dojenje ili prekinuti uzimati lijek.
English: Whilst clinical trials experience in paediatrics with LHON is limited to patients of 14 years of age and above, pharmacokinetic data from population pharmacokinetic studies, which included paediatric Friedreich's Ataxia patients of age 8 years and above, did not reveal any significant differences in the pharmacokinetics of idebenone.
Croatian: Iako je iskustvo u pedijatrijskoj populaciji s LHON-om u kliničkim ispitivanjima ograničeno na bolesnike u dobi od 14 godina i starije, farmakokinetički podaci dobiveni populacijskim farmakokinetičkim ispitivanjima, koji su uključivali pedijatrijske bolesnike s Friedreichovom ataksijom u dobi od 8 godina i starije, nisu otkrili nikakve značajne razlike u farmakokinetici idebenona.
English: In the EAP the number of responders increased with longer treatment duration, from 19 out of 62 patients (30.6%) at 6 months to 17 out of 47 patients (36.2%) at 12 months.
Croatian: U programu proširenog pristupa broj bolesnika koji su odgovorili na liječenje povećao se sukladno duljem trajanju liječenja, i to s 19 od 62 bolesnika (30,6%) u 6. mjesecu na 17 od 47 bolesnika (36,2%) u 12. mjesecu.
English: Idebenone shows a high first pass metabolism resulting in conjugates of idebenone (glucuronides and sulphates (IDE-C)) and the Phase I metabolites QS10, QS6, and QS4 as well as their corresponding Phase II metabolites (glucuronides and sulphates (QS10+QS10-C, QS6+QS6-C, QS4+QS4-C)).
Croatian: Idebenon je pokazao visoki metabolizam prvog prolaza koji je rezultirao konjugatima idebenona (glukuronidima i sulfatima (IDE-C)) i metabolitima faze I QS10, QS6 i QS4 kao i njihovim odgovarajućim metabolitima faze II (glukuronidi i sulfati (QS10+QS10-C, QS6+QS6-C, QS4+QS4-C)).
English: Due to the high first-pass effect, the plasma concentrations of idebenone were generally only measurable up to 6 hours after oral administration of 750 mg Raxone, given either as a single oral dose or after repeated (14 days) t.i.d dosing.
Croatian: Uslijed visokog učinka prvog prolaza, koncentracije idebenona u plazmi bile su uglavnom mjerljive samo do 6 sati nakon peroralne primjene 750 mg lijeka Raxone, koji se primijenio kao jednokratna oralna doza ili nakon ponovljenog (14 dana) doziranja tri puta na dan.
English: The safety and efficacy of Raxone in LHON patients under 12 years of age have not yet been established.
Croatian: Pedijatrijska populacija Sigurnost i djelotvornost lijeka Raxone u bolesnika s LHON-om mlađih od 12 godina nisu još ustanovljene.
English: Do not use this medicine after the expiry date which is stated on the carton and the bottle after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i boci iza "Rok valjanosti".
English: Raxone contains a substance called idebenone.
Croatian: Raxone sadrži tvar koja se naziva idebenon.
English: In vivo idebenone is a mild inhibitor of CYP3A4.
Croatian: In vivo, idebenon je blagi inhibitor citokroma CYP3A4.
English: The main route of elimination is metabolism, with the majority of dose excreted via the kidneys as metabolites.
Croatian: Glavni put eliminacije je metabolizam, pri čemu se većina doze izlučuje putem bubrega u obliku metabolita.
English: Best recovery of VA (mean ± SE; 95%CI)
Croatian: Najbolji oporavak oštrine vida (srednja vrijednost ± SE; 95%CI)
English: The following side effect may happen with this medicine:
Croatian: Uz ovaj lijek mogu se pojaviti sljedeće nuspojave:
English: Idebenone, a short-chain benzoquinone, is an anti-oxidant assumed to be capable of transferring electrons directly to complex III of the mitochondrial electron transport chain, thereby circumventing complex I and restoring cellular energy (ATP) generation under experimental conditions of complex I deficiency.
Croatian: Idebenon, benzokinon kratkog lanca, je antioksidans za kojeg se pretpostavlja da je sposoban za prijenos elektrona izravno u kompleks III mitohondrijskog lanca prijenosa elektrona, te tako zaobilazi kompleks I i uspostavlja stvaranje stanične energije (ATP-a) u eksperimentalnim uvjetima nedostatka kompleksa I.
English: Raxone contains lactose.
Croatian: Raxone sadrži laktozu.
English: No report of overdose has been received from the RHODOS study.
Croatian: Na temelju ispitivanja RHODOS nisu zaprimljeni izvještaji o predoziranju.
English: After repeated administration Cmax and AUC of midazolam were increased by 28% and 34%, respectively, when midazolam was administered in combination with 300 mg idebenone t.i.d.
Croatian: Nakon ponovljene primjene Cmax i AUC midazolama povećali su se za 28% odnosno 34%, kada je midazolam primijenjen u kombinaciji s 300 mg idebenona tri puta na dan.
English: Data from in vitro studies have demonstrated that idebenone and its metabolite QS10 do not exert systemic inhibition of cytochrome P450 isoforms CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4 at clinically relevant concentrations of idebenone or QS10.
Croatian: Podaci prikupljeni in vitro ispitivanjima pokazuju da idebenon i njegov metabolit QS10 ne uzrokuju sistemsku inhibiciju izoformi citokroma P450: CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 i 3A4 u klinički relevantnim koncentracijama idebenona ili QS10.
English: In addition, no induction of CYP1A2, CYP2B6 or CYP3A4 was observed.
Croatian: Nadalje, nije uočena indukcija CYP1A2, CYP2B6