FrancophonIA/ELRC3.0 huggingface dataset:
English: This medicine should not be used during pregnancy unless clearly necessary.
Croatian: Ovaj se lijek ne smije uzimati u trudnoći, osim ako je to neophodno.
English: Aprepitant plasma concentrations achieved with the 3-day regimen of EMEND in adults are predicted to provide greater than 95 % occupancy of brain NK1 receptors.
Croatian: Predviđa se da će se pri koncentraciji aprepitanta u plazmi postignutoj trodnevnim režimom primjene EMEND u odraslih vezati na više od 95% NK1 receptora u mozgu.
English: Table 3 Percent of adult patients responding by treatment group and phase for Study 2 - Cycle 1 Moderately Emetogenic Chemotherapy
Croatian: Tablica 3 Postotak odraslih bolesnika koji su odgovorili na liječenje, prema terapijskoj skupini i fazi liječenja za Ispitivanje 2 -1. ciklus umjereno emetogena kemoterapija
English: COMPOSITE MEASURES
Croatian: KOMPOZITNA MJERA
English: How much to take - The doctor will work out the right dose of powder for oral suspension based on the weight of the child. - Do not change the dose or stop treatment without first talking to the doctor, pharmacist or nurse.
Croatian: Koliko uzeti - Liječnik će izračunati pravu dozu praška za oralnu suspenziju na temelju tjelesne težine djeteta.
English: Before treatment with EMEND, tell your doctor if you have liver disease because your liver is important in breaking down the medicine in your body.
Croatian: Prije liječenja lijekom EMEND recite svom liječniku ako imate bolest jetre jer je Vaša jetra vrlo važna za razgradnju lijeka u Vašem tijelu.
English: Each hard capsule contains 165 mg of aprepitant.
Croatian: Jedna tvrda kapsula sadrži 165 mg aprepitanta.
English: Elderly: Following oral administration of a single 125 mg dose of aprepitant on Day 1 and 80 mg once daily on Days 2 through 5, the AUC0-24hr of aprepitant was 21 % higher on Day 1 and 36 % higher on Day 5 in elderly ( 65 years) relative to younger adults.
Croatian: Starije osobe: Nakon jednokratne primjene peroralne doze aprepitanta od 125 mg 1. dana te 80 mg jedanput na dan od 2. do 5. dana, u starijih je osoba (≥65 godina) AUC0-24hr aprepitanta porastao za 21% 1. dana, odnosno 36% 5. dana liječenja, u odnosu na mlađe odrasle osobe.
English: Warnings and precautions Talk to your doctor, pharmacist, or nurse before taking this medicine.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete ovaj lijek.
English: In a clinical study, single doses of an oral contraceptive containing ethinyl estradiol and norethindrone were administered on Days 1 through 21 with EMEND, given as a regimen of 125 mg on Day 8 and 80 mg/day on Days 9 and 10 with ondansetron 32 mg intravenously on Day 8 and oral dexamethasone given as 12 mg on Day 8 and 8 mg/day on Days 9, 10, and 11.
Croatian: U kliničkom ispitivanju pojedinačne doze peroralnog kontraceptiva koji je sadržavao etinilestradiol i noretindron primijenjene su 1. do 21. dan liječenja, uz EMEND primijenjen kao režim od 125 mg 8. dan te 80 mg na dan 9. i 10. dana u kombinaciji s ondanzetronom u intravenskoj dozi od 32 mg 8. dan i peroralnim deksametazonom u dozi od 12 mg 8. dan te 8 mg 9., 10. i 11. dan.
English: Nervous system disorders dysarthria, hypoaesthesia, sensory disturbance uncommon
Croatian: Poremećaji živčanog sustava disartrija, hipoestezija, poremećaji osjeta manje često
English: Effect of other medicinal products on the pharmacokinetics of aprepitant Concomitant administration of EMEND with active substances that inhibit CYP3A4 activity (e.g., ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, telithromycin, nefazodone, and protease inhibitors) should be approached cautiously, as the combination is expected to result several-fold in increased plasma concentrations of aprepitant (see section 4.4).
Croatian: Treba pozorno razmotriti istodobnu primjenu lijeka EMEND i djelatnih tvari koje inhibiraju aktivnost CYP3A4 (npr. ketokonazola, itrakonazola, vorikonazola, posakonazola, klaritromicina, telitromicina, nefazodona i inhibitora proteaze) jer se očekuje da bi takva kombinacija mogla višestruko povisiti koncentraciju aprepitanta u plazmi (vidjeti dio 4.4).
English: p < 0.01 when compared to control regimen p < 0.05 when compared to control regimen No vomiting = No vomiting or retching or dry heaves n/m = Number of patients with desired response/number of patients included in time point.
Croatian: p < 0,01 u usporedbi s kontrolnim režimom p < 0,05 u usporedbi s kontrolnim režimom Bez povraćanja
English: In an additional active-controlled clinical study in 1,169 adult patients receiving the 3-day oral aprepitant regimen and HEC, the adverse reactions profile was generally similar to that seen in the other HEC studies with the 3-day oral aprepitant regimen.
Croatian: U drugom ispitivanju s aktivnom kontrolom s 1169 odraslih bolesnika koji su primali trodnevni režim peroralno primjenjenog aprepitanta i HEC, profil nuspojava uglavnom je bio sličan onom zabilježenom u drugim HEC ispitivanjima trodnevnog režima liječenja peroralno primjenjenim aprepitantom.
English: In a juvenile toxicity study in rats treated from post natal day 10 to day 63 aprepitant led to an earlier vaginal opening in females from 250 mg/kg b.i.d.
Croatian: U ispitivanju toksičnosti na mladunčadi štakora, liječenje aprepitantom od 10. do 63. postnatalnog dana dovelo je do ranijeg otvaranja vagine u ženki kod doza od 250 mg/kg dvaput na dan i do kasnijeg razdvajanja prepucija u mužjaka kod doza od 10 mg/kg dvaput na dan.
English: Capsules are opaque with a light blue cap and a white body with “466” and “165 mg” printed radially in black ink on one side of the body and the Merck logo on the other side.
Croatian: Kapsule su neprozirne, sa svijetloplavom kapicom i bijelim tijelom te poprečno otisnutim crnim oznakama "466" i "165 mg" na jednoj strani tijela kapsule i Merck logom otisnutim na drugoj strani.
English: How to store EMEND
Croatian: Kako čuvati EMEND
English: The reduction in risk for a vomiting episode over the 0 to 24 hour period with aprepitant 40 mg relative to ondansetron 4 mg was 53.3 % (95 % C.I.
Croatian: Smanjenje rizika za nastup epizode povraćanja u razdoblju od 0 do 24 sata nakon operacije bilo je 53,3% kod primjene aprepitanta 40 mg u odnosu na ondanzetron 4 mg (95% CI: 35,3 do 66,3) u analizi koja isključuje bolesnike koji su uzeli dodatni lijek za olakšanje simptoma.
English: No dose adjustment is necessary based on gender (see section 5.2).
Croatian: Nije potrebno prilagođavati dozu s obzirom na spol bolesnika (vidjeti dio 5.2).
English: This increase is not considered clinically relevant.
Croatian: To povećanje ne smatra se klinički značajno.
English: The most common adverse reactions reported at a greater incidence in adults treated with the aprepitant regimen than with standard therapy in patients receiving Highly Emetogenic Chemotherapy (HEC) were: hiccups (4.6 % versus 2.9 %), alanine aminotransferase (ALT) increased (2.8 % versus 1.1 %), dyspepsia (2.6 % versus 2.0 %), constipation (2.4 % versus 2.0 %), headache (2.0 % versus 1.8 %), and decreased appetite (2.0 % versus 0.5 %).
Croatian: Highly Emetogenic Chemotherapy, HEC) bile su: štucanje (4,6% naspram 2,9%), povišene vrijednosti alanin aminotransferaze (ALT) (2,8% naspram 1,1%), dispepsija (2,6% naspram 2,0%), konstipacija (2,4% naspram 2,0%), glavobolja (2,0% naspram 1,8%) i smanjeni apetit (2,0% naspram 0,5%).
English: Gastrointestinal disorders abdominal pain upper, bowel sounds abnormal, dry mouth, nausea, stomach discomfort, constipation*, sub-ileus*
Croatian: Poremećaji probavnog sustava bol u gornjem dijelu abdomena, neobični zvukovi u crijevima, suha usta, mučnina, osjećaj nelagode u trbuhu, konstipacija*, subileus*
English: Warnings and precautions Talk to the doctor, pharmacist, or nurse before giving this medicine to the child.
Croatian: Upozorenja i mjere opreza Obratite se liječniku, ljekarniku ili medicinskoj sestri prije nego djetetu date ovaj lijek.
English: Each capsule contains 165 mg of aprepitant.
Croatian: Jedna kapsula sadrži 165 mg aprepitanta.
English: The following adverse reactions were observed in a pooled analysis of the HEC and MEC studies at a greater incidence with aprepitant than with standard therapy or in postmarketing use.
Croatian: Sljedeće nuspojave bile su opažene u analizi objedinjenih podataka iz ispitivanja s HEC-om i MEC-om s većom incidencijom uz aprepitant nego uz standardnu terapiju ili u razdoblju nakon stavljanja lijeka u promet.
English: Aluminium blister containing one 165 mg capsule.
Croatian: Aluminijski blister s jednom kapsulom od 165 mg.
English: If you are not sure, talk to the doctor, pharmacist or nurse before giving this medicine.
Croatian: Ako niste sigurni, prije davanja ovog lijeka obratite se liječniku, ljekarniku ili medicinskoj sestri.
English: 5 Aluminium blisters each containing one 125 mg capsule.
Croatian: 5 aluminijskih blistera od kojih svaki sadrži jednu kapsulu od 125 mg.
English: Because the effect of EMEND on the pharmacokinetics of orally administered CYP3A4 substrates is greater than the effect of EMEND on the pharmacokinetics of intravenously administered CYP3A4 substrates, an interaction with orally administered chemotherapeutic medicinal products metabolised primarily or partly by CYP3A4 (e.g., etoposide, vinorelbine) cannot be excluded.
Croatian: Budući da EMEND snažnije utječe na farmakokinetiku supstrata CYP3A4 koji se daju peroralno nego onih koji se daju intravenski, ne može se isključiti interakcija s peroralno primjenjenim kemoterapeuticima koji se primarno ili dijelomično metaboliziraju putem CYP3A4 (npr. etopozid, vinorelbin).
English: A dose reduction (50 %) of dexamethasone was required for paediatric patients receiving aprepitant.
Croatian: U pedijatrijskih bolesnika koji su primali aprepitant bilo je potrebno sniziti dozu deksametazona (50 %).
English: Titanium dioxide (E 171) Yellow iron oxide (E 172)
Croatian: Ovojnica kapsule želatina titanijev dioksid (E 171) željezov oksid, žuti (E 172)
English: In 2 randomised, double-blind studies encompassing a total of 1,094 adult patients receiving chemotherapy that included cisplatin  70 mg/m2, aprepitant in combination with an ondansetron/dexamethasone regimen (see section 4.2) was compared with a standard regimen (placebo plus ondansetron 32 mg intravenously administered on Day 1 plus dexamethasone 20 mg orally on Day 1 and 8 mg orally twice daily on Days 2 to 4).
Croatian: Trodnevni režim liječenja aprepitantom u odraslih U dva randomizirana, dvostruko slijepa ispitivanja s ukupno 1094 odraslih bolesnika koji primaju kemoterapiju koja je uključivala cisplatin u dozi od ≥70 mg/m2, uspoređen je režim liječenja aprepitantom u kombinaciji s ondanzetronom/deksametazonom (vidjeti dio 4.2) sa standardnim režimom (placebo s ondanzetronom primijenjenim intravenski u dozi od 32 mg 1. dan te peroralnim deksametazonom u dozi od 20 mg 1. dan i 8 mg dvaput na dan 2. do 4. dana).
English: Caution is advised when warfarin, acenocoumarol, tolbutamide, phenytoin or other active substances that are known to be metabolised by CYP2C9 are administered with EMEND 165 mg.
Croatian: Potreban je oprez pri istodobnoj primjeni lijeka EMEND 165 mg i varfarina, acenokumarola, tolbutamida, fenitoina ili drugih djelatnih tvari za koje se zna da se metaboliziraju putem CYP2C9.
English: Aluminium blister containing one 125 mg capsule.
Croatian: Aluminijski blister s jednom kapsulom od 125 mg.
English: Each 80 mg capsule contains 80 mg of aprepitant.
Croatian: Jedna kapsula od 80 mg sadrži 80 mg aprepitanta.
English: A summary of the key study results from the combined analysis is shown in Table 1.
Croatian: Tablici 1 sažeti su ključni rezultati dobiveni analizom udruženih podataka.
English: When a single 125 mg dose of aprepitant was administered on Day 5 of a 10-day regimen of 400 mg/day of ketoconazole, a strong CYP3A4 inhibitor, the AUC of aprepitant increased approximately 5-fold and the mean terminal half-life of aprepitant increased approximately 3-fold.
Croatian: Primjena jednokratne doze aprepitanta od 125 mg 5. dan desetodnevnog režima liječenja s 400 mg na dan ketokonazola, snažnog inhibitora CYP3A4, AUC aprepitanta povećao se približno 5 puta a srednje terminalno poluvrijeme aprepitanta produljilo se približno 3 puta.
English: Following oral administration of a single 125 mg dose of EMEND on Day 1 and 80 mg once daily on Days 2 and 3, the AUC0-24hr (mean±SD) was 19.6 ± 2.5 µg•h/mL and 21.2 ± 6.3 µg •h/mL on Days 1 and 3, respectively.
Croatian: Nakon peroralne primjene jedne EMEND 125 mg kapsule 1. dan te EMEND 80 mg kapsula jedanput na dan 2. i 3. dan, AUC0-24hr aprepitanta (srednja vrijednost ± SD) iznosio je 19,6 ± 2,5 μg•h/ml 1. dana, odnosno 21,2 ± 6,3 μg•h/ml 3. dan liječenja.
English: EMEND 165 mg hard capsules
Croatian: EMEND 165 mg tvrde kapsule
English: As a weak inhibitor of CYP3A4, aprepitant (40 mg) can increase plasma concentrations of orally co-administered active substances that are metabolised through CYP3A4.
Croatian: Kao slabi inhibitor izoenzima CYP3A4, aprepitant (40 mg) može povisiti koncentracije u plazmi onih peroralno primjenjenih lijekova koji se metaboliziraju putem CYP3A4, a primjenjuju se istodobno s njime.
English: Skin and subcutaneous tissue disorders rash, acne uncommon photosensitivity reaction, hyperhidrosis, seborrhoea, skin lesion, rash pruritic, Stevens-Johnson syndrome/toxic epidermal necrolysis rare pruritus, urticaria not known
Croatian: Poremećaji kože i potkožnog tkiva osip, akne manje često reakcije fotosenzitivnosti, hiperhidroza, seboreja, kožne lezije, osip koji svrbi, StevensJohnsonov sindrom/toksična epidermalna nekroliza rijetko pruritus, urtikarija nepoznato
English: After the treatment, EMEND causes a transient mild induction of CYP2C9, CYP3A4 and glucuronidation.
Croatian: Po završetku primjene, EMEND uzrokuje prolaznu blagu indukciju CYP2C9, CYP3A4 i glukuronidaciju.
English: In an additional active-controlled clinical study in 1,169 adult patients receiving aprepitant and HEC, the adverse reactions profile was generally similar to that seen in the other HEC studies with aprepitant.
Croatian: U drugom ispitivanju s aktivnom kontrolom s 1169 odraslih bolesnika koji su primali aprepitant i HEC, profil nuspojava uglavnom je bio sličan onom zabilježenom u ostalim HEC ispitivanjima s aprepitantom.
English: Overall phase: 0 to 120 hours following initiation of chemotherapy.
Croatian: Cijelo razdoblje: od 0 do 120 sati nakon početka kemoterapije.
English: As a mild inducer of CYP2C9, CYP3A4 and glucuronidation, aprepitant can decrease plasma concentrations of substrates eliminated by these routes within two weeks following initiation of treatment.
Croatian: Kao blagi induktor izoenzima CYP2C9, CYP3A4 i glukuronidacije, tijekom dva tjedna nakon početka primjene režima liječenja, aprepitant može smanjiti koncentraciju u plazmi onih supstrata koji se uklanjaju ovim putovima.
English: In a third study with intravenous and oral administration of midazolam, EMEND was given as 125 mg on Day 1 and 80 mg/day on Days 2 and 3, together with ondansetron 32 mg Day 1, dexamethasone 12 mg Day 1 and 8 mg Days 2-4.
Croatian: U trećem ispitivanju intravenske i peroralne primjene midazolama, EMEND se davao u dozi od 125 mg 1. dan i 80 mg na dan 2. i 3. dan zajedno s ondanzetronom u dozi od 32 mg 1. dan, deksametazonom u dozi od 12 mg 1. dan i 8 mg 2. do 4. dan..
English: Aprepitant is a substrate, and a dose-dependent inhibitor, and an inducer of CYP3A4.
Croatian: Aprepitant je supstrat i o dozi ovisan inhibitor, ali i induktor izoenzima CYP3A4.
English: Each 125 mg capsule contains 125 mg of aprepitant.
Croatian: Jedna kapsula od 125 mg sadrži 125 mg aprepitanta.
English: Each capsule contains 40 mg of aprepitant.
Croatian: Jedna kapsula sadrži 40 mg aprepitanta.
English: When a single 375 mg dose of aprepitant was administered on Day 9 of a 14-day regimen of 600 mg/day of rifampicin, a strong CYP3A4 inducer, the AUC of aprepitant decreased 91 % and the mean terminal half-life decreased 68 %.
Croatian: Jednokratna primjena aprepitanta u dozi od 375 mg 9. dan tijekom četrnaestodnevnog režima liječenja sa 600 mg na dan rifampicina, snažnog induktora CYP3A4, smanjila je AUC aprepitanta za 91% te skratila srednje terminalno poluvrijeme za 68%.
English: As a moderate inhibitor of CYP3A4, aprepitant can increase plasma concentrations of co-administered active substances that are metabolised through CYP3A4.
Croatian: Kao umjereni inhibitor izoenzima CYP3A4, aprepitant može povisiti koncentracije u plazmi onih djelatnih tvari koje se metaboliziraju putem CYP3A4, a primjenjuju se istodobno s njime.
English: Each hard capsule contains 40 mg of aprepitant.
Croatian: Jedna tvrda kapsula sadrži 40 mg aprepitanta.
English: As a mild inducer of CYP2C9, CYP3A4 and glucuronidation, aprepitant can decrease plasma concentrations of substrates eliminated by these routes.
Croatian: Kao blagi induktor izoenzima CYP2C9, CYP3A4 i glukuronidacije, tijekom 2 tjedna nakon početka liječenja, aprepitant može smanjiti koncentraciju u plazmi onih supstrata koji se uklanjaju ovim putovima.
English: Aprepitant plasma concentrations achieved with the 3-day regimen of EMEND are predicted to provide greater than 95 % occupancy of brain NK1 receptors.
Croatian: Predviđa se da će se pri koncentraciji aprepitanta u plazmi postignutoj trodnevnim režimom primjene EMEND vezati na više od 95% NK1 receptora u mozgu.
English: The aprepitant regimen in combination with an ondansetron/dexamethasone regimen (see section 4.2) was compared with standard therapy (placebo in combination with ondansetron 8 mg orally (twice on Day 1, and every 12 hours on Days 2 and 3) plus dexamethasone 20 mg orally on Day 1).
Croatian: Režim liječenja aprepitantom u kombinaciji s ondanzetronom/deksametazonom (vidjeti dio 4.2) uspoređen je sa standardnom terapijom (placebo s peroralnim ondanzetronom u dozi od 8 mg (dvaput na dan 1. dan te svakih 12 sati 2. i 3. dan) i peroralnim deksametazonom u dozi od 20 mg 1. dan).
English: Dizziness and fatigue may occur following administration of EMEND (see section 4.8).
Croatian: EMEND mogu se javiti omaglica i umor (vidjeti dio 4.8).
English: Warnings and precautions Talk to the doctor, pharmacist, or nurse before you take EMEND or give this medicine to the child.
Croatian: Obratite se liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete EMEND ili date ovaj lijek djetetu.
English: The 125 mg capsule is opaque with a white body and pink cap with “462” and “125 mg” printed radially in black ink on the body.
Croatian: Kapsule od 125 mg su neprozirne, s bijelim tijelom i ružičastom kapicom te poprečno otisnutim crnim oznakama "462" i "125 mg" na tijelu kapsule.
English: EMEND, when given as a regimen of 125 mg with dexamethasone co-administered orally as 20 mg on Day 1, and EMEND when given as 80 mg/day with dexamethasone co-administered orally as 8 mg on Days 2 through 5, increased the AUC of dexamethasone, a CYP3A4 substrate, 2.2-fold on Days 1 and 5.
Croatian: EMEND u dozi od 125 mg primijenjen istodobno s peroralnim deksametazonom u dozi od 20 mg 1. dan liječenja i EMEND u dozi od 80 mg na dan primijenjen s peroralnim deksametazonom u dozi od 8 mg od 2. do 5. dana liječenja povisili su 2,2 puta AUC deksametazona, supstrata CYP3A4, 1. i 5. dan liječenja.
English: These studies did not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Croatian: Ta ispitivanja nisu ukazala na izravne ili neizravne štetne učinke na trudnoću, embriofetalni razvoj, okot niti postnatalni razvoj (vidjeti dio 5.3).
English: (IUDs) that release hormones.
Croatian: implantate i neke intrauterine uloške koji oslobađaju hormone.
English: In animal studies there was no indication of direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Croatian: Ispitivanja na životinjama nisu ukazala na izravno ili neizravno štetno djelovanje na trudnoću, embriofetalni razvoj, okot niti postnatalni razvoj (vidjeti dio 5.3).
English: Table 2 Percent of adult patients responding by treatment group and phase - Cycle 1 Moderately Emetogenic Chemotherapy
Croatian: Tablica 2 Postotak odraslih bolesnika koji su odgovorili na liječenje, prema terapijskoj skupini i fazi liječenja1. ciklus, umjereno emetogena kemoterapija
English: 5 Aluminium blisters each containing one 80 mg capsule.
Croatian: 5 aluminijskih blistera od kojih svaki sadrži jednu kapsulu od 80 mg.
English: Your child may need blood tests during treatment with EMEND - antibiotics to treat infections - such as rifampicin, clarithromycin, telithromycin - phenytoin - for fits (seizures) - carbamazepine - for depression and epilepsy - midazolam, triazolam, phenobarbital - to produce calmness or help you sleep - St. John's Wort - a herbal medicine for depression - protease inhibitors - for HIV infections - ketoconazole except shampoo (used to treat Cushing's syndrome - when the body produces an excess of cortisol) - antifungal medicines such as itraconazole, voriconazole, posaconazole - nefazodone - for depression - corticosteroids - such as dexamethasone and methylprednisolone - medicines for anxiety such as alprazolam - tolbutamide - for diabetes - contraceptive medicines including pills, patches, implants, and some Intrauterine devices
Croatian: Možda će Vašem djetetu biti potrebne krvne pretrage tijekom liječenja lijekom EMEND - antibiotike za liječenje infekcija - kao što su rifampicin, klaritromicin, telitromicin - fenitoin - za liječenje epileptičkih napadaja - karbamazepin - za liječenje depresije i epilepsije - midazolam, triazolam, fenobarbital - za smirenje ili spavanje - gospinu travu - biljni lijek za liječenje depresije - inhibitore proteaze - za liječenje HIV infekcije - ketokonazol, izuzev šampona (primjenjuje se za liječenje Cushingovog sindroma - kad se u tijelu stvara previše kortizola) - lijekove za liječenje gljivičnih infekcija kao što su itrakonazol, vorikonazol, posakonazol - nefazodon - za liječenje depresije - kortikosteroide - kao što su deksametazon i metilprednizolon - lijekove protiv tjeskobe kao što je alprazolam - tolbutamid - za liječenje šećerne bolesti - sredstva za kontrolu začeća, uključujući kontracepcijske tablete, hormonske flastere za kožu,
English: Stevens-Johnson syndrome/toxic epidermal necrolysis (rare severe skin reaction), - euphoria (feeling of extreme happiness), disorientation, - bacterial infection, fungal infection, - severe constipation, stomach ulcer, inflammation of the small intestine and colon, sores in mouth, bloating, - frequent urination, passing more urine than normal, presence of sugar or blood in urine, - chest discomfort, swelling, change in the manner of walking, - cough, mucus in back of throat, throat irritation, sneezing, sore throat, - eye discharge and itching, - ringing in the ear, - muscle spasms, muscle weakness, - excessive thirst, - slow heartbeat, heart and blood vessel disease, - lowering of white blood cells, low sodium levels in the blood, weight loss.
Croatian: Stevens-Johnsonov sindrom/toksična epidermalna nekroliza (rijetka teška kožna reakcija), - euforija (osjećaj ekstremne sreće), dezorijentiranost, - bakterijska infekcija, gljivična infekcija, - teški zatvor, vrijed na želucu, upala tankog i debelog crijeva, ranice u ustima, nadutost - učestalo mokrenje, mokrenje više nego uobičajeno, prisutnost glukoze ili krvi u mokraći, - nelagoda u prsima, oticanje, promjene u načinu hoda, - kašalj, slijevanje sluzi u grlo, iritacija grla, kihanje, upala grla, - svrbež i iscjedak iz oka, - zujanje u ušima, - grčevi u mišićima, slabost mišića, - pretjerana žeđ, - usporeni otkucaji srca, bolest srca i krvnih žila, - smanjenje broja bijelih krvnih stanica, snižene vrijednosti natrija u krvi, gubitak tjelesne težine.
English: Cardiac disorders bradycardia uncommon
Croatian: Učestalost bradikardija, kardiovaskularni poremećaj rijetko
English: EMEND 80 mg hard capsules Aprepitant
Croatian: EMEND 80 mg tvrde kapsule aprepitant