FrancophonIA/ELRC3.0 huggingface dataset:
English: Riarify contains beclometasone dipropionate, formoterol and glycopyrronium in a solution formulation resulting in an aerosol with extrafine particles with an average mass median aerodynamic diameter (MMAD) of around 1.1 micrometres and co-deposition of the three components.
Croatian: Riarify sadrži beklometazondipropionat, formoterol i glikopironij u obliku otopine koja se može raspršiti u aerosol s vrlo sitnim česticama prosječnog medijana masenog aerodinamičkog promjera
English: • irritation of the throat
Croatian: • nadraženost grla
English: Riarify 87/5/9 micrograms pressurised inhalation beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium Inhalation use
Croatian: Riarify 87/5/9 mikrograma stlačeni inhalat beklometazondipropionat/formoterolfumarat dihidrat/glikopironij
English: In an inhalation study in telemetered dogs, the cardiovascular system was a major target system for acute effects of Riarify (increase in heart rate, decrease in blood pressure, ECG changes at higher doses), effects probably mainly related to the beta2-adrenergic activity of formoterol and the anti-muscarinic activity of glycopyrronium.
Croatian: U inhalacijskom ispitivanju na telemetrijski praćenim psima, glavni ciljni sustav akutnih učinaka lijeka Riarify bio je kardiovaskularni sustav (povećanje srčane frekvencije, sniženje krvnog tlaka,
English: Patients with severe renal impairment
Croatian: Bolesnici s teškim oštećenjem funkcije bubrega
English: • nose bleeds
Croatian: • upala sinusa
English: Hold your inhaler upright with the mouthpiece at the bottom Direct the mouthpiece away from yourself and firmly press the pressurised container to release one puff
Croatian: Usmjerite nastavak za usta od sebe i čvrsto pritisnite spremnik pod tlakom kako biste oslobodili jednu raspršenu dozu.
English: IMPORTANT: steps 2 to 5 should not be performed too quickly: Patients should remove the protective cap from the mouthpiece and check that the mouthpiece is clean and free from dust and dirt or any other foreign objects.
Croatian: Bolesnici trebaju ukloniti zaštitni zatvarač s nastavka za usta i provjeriti da je nastavak za usta čist i da nije prašnjav i prljav te da ne sadrži nikakve druge strane predmete.
English: • hoarseness
Croatian: • omaglica
English: Each metered dose (the dose leaving the valve) contains 100 micrograms of beclometasone dipropionate, 6 micrograms of formoterol fumarate dihydrate and 10 micrograms of glycopyrronium.
Croatian: Jedna odmjerena doza (doza koja izađe iz ventila) sadrži 100 mikrograma beklometazondipropionata, 6 mikrograma formoterolfumarat dihidrata i 10 mikrograma glikopironija.
English: After repeated inhalation of twice daily doses ranging from 12.5 to 50 micrograms via pressurised metered dose inhaler in COPD patients, glycopyrronium showed linear pharmacokinetics with little systemic accumulation at steady state (median accumulation ratio
Croatian: Nakon ponovljene inhalacije doza u rasponu od 12,5 do 50 mikrograma dva puta dnevno iz stlačenih inhalata u bolesnika s KOPB-om,
English: Muscle spasms, myalgia, pain in extremity1, musculoskeletal chest pain1
Croatian: Poremećaji mišićno koštanog sustava i vezivnog tkiva mišićni grčevi, mialgija, bol u ekstremitetima1, bol u kostima i mišićima prsnog koša1
English: In addition, compared with both a fixed combination of beclometasone dipropionate and formoterol and with tiotropium, Riarify significantly prolonged the time to first exacerbation (hazard ratio 0.80 and 0.84 respectively; p = 0.020 and 0.015 respectively), with no differences between Riarify and the extemporary triple combination made of beclometasone dipropionate and formoterol fixed combination plus tiotropium (hazard ratio 1.06).
Croatian: 0,84; p = 0,020 odnosno p = 0,015), s time da nije bilo razlika između lijeka Riarify i ex tempore trostruke fiksne kombinacije beklometazondipropionata i formoterola uz tiotropij (omjer hazarda
English: Each metered dose (the dose leaving the valve) contains 100 micrograms of beclometasone dipropionate, 6 micrograms of formoterol fumarate dihydrate and 10 micrograms of glycopyrronium (as 12.5 micrograms of glycopyrronium bromide).
Croatian: Jedna odmjerena doza (doza koja izađe iz ventila) sadrži 100 mikrograma beklometazondipropionata, 6 mikrograma formoterolfumarat dihidrata i 10 mikrograma glikopironija (u obliku 12,5 mikrograma glikopironijevog bromida).
English: Study TRINITY compared Riarify with tiotropium 18 micrograms inhalation powder, hard capsule, one inhalation once daily; in addition, effects were compared with an extemporary triple combination made of a fixed combination of beclometasone dipropionate and formoterol 100/6 micrograms two inhalations twice daily plus tiotropium 18 micrograms inhalation powder, hard capsule, one inhalation once daily (2,691 randomised patients).
Croatian: osim toga, učinci su bili uspoređeni s učincima ex tempore trostruke kombinacije napravljene od fiksne kombinacije beklometazondipropionata i formoterola 100/6 mikrograma za dva udaha dvaput na dan i tiotropija 18 mikrograma praška inhalata, tvrde kapsule, primijenjenog kao jedan udah jedanput na dan (2691 randomiziran bolesnik).
English: Priming the inhaler
Croatian: Priprema inhalatora
English: This may be obtained by the patients using the AeroChamber Plus by one continuous slow and deep breath through the spacer, without any delay between actuation and inhalation.
Croatian: AeroChamber Plus kroz koju mogu polako i duboko udahnuti, s time da potisak mora biti istovremen s udisanjem.
English: Systemic exposure (AUC0-t) to beclometasone dipropionate, to its metabolite beclometasone 17-monopropionate and to formoterol was not affected by mild to severe renal impairment.
Croatian: beklometazondipropionatu, njegovom metabolitu beklometazon 17-monopropionatu i formoterolu.
English: • if you have difficulty passing urine.
Croatian: • ako Vam je mokrenje otežano.
English: Patients should stand or sit in an upright position when inhaling from their inhaler.
Croatian: Za vrijeme udisanja lijeka iz inhalatora bolesnici trebaju stajati ili sjediti u uspravnom položaju.
English: Related to glycopyrronium
Croatian: Povezane s glikopironijem
English: If you use more Riarify than you should, side effects, as described in section 4, may occur.
Croatian: Ako primijenite više lijeka Riarify nego što ste trebali, može doći do nuspojava koje su opisane u dijelu 4. Ako ste primijenili više lijeka Riarify nego što ste trebali i ako Vam se javi bilo koji od tih simptoma, obratite se svome liječniku.
English: A total
Croatian: I DOHVATA
English: Hypersensitivity reactions, including erythema, lips, face, eye and pharyngeal oedema
Croatian: manje često reakcije preosjetljivosti, uključujući eritem, edem usana,
English: Formoterol
Croatian: OBLIK
English: Bronchospasm paradoxical1, oropharyngeal pain, pharyngeal erythema, pharyngeal inflammation, dry throat
Croatian: manje često paradoksalni bronhospazam1, orofaringealna bol, eritem ždrijela, upala ždrijela, suhoća grla rijetko dispneja1
English: Use of the inhaler
Croatian: Upotreba inhalatora
English: • low level in the number of certain blood cells called platelets
Croatian: • nizak broj određenih krvnih stanica koje se nazivaju krvne pločice • osjećaj zadihanosti ili nedostatak zraka
English: Blood pressure increased1, blood pressure decreased1
Croatian: manje često povišen krvni tlak1, snižen krvni tlak1
English: • restlessness
Croatian: • utrnulost
English: Package leaflet: Information for the user Riarify 87 micrograms/5 micrograms/9 micrograms pressurised inhalation, solution beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium
Croatian: Riarify 87 mikrograma/5 mikrograma/9 mikrograma stlačeni inhalat, otopina beklometazondipropionat/formoterolfumarat dihidrat/glikopironij
English: How to store Riarify
Croatian: Moguće nuspojave Kako čuvati Riarify
English: Name and address of the manufacturers responsible for batch release
Croatian: PROIZVOĐAČI ODGOVORNI ZA PUŠTANJE SERIJE LIJEKA U PROMET Naziv i adresa proizvođača odgovornih za puštanje serije lijeka u promet
English: If you have been prescribed a container providing 180 puffs There is an indicator on the back of the inhaler, which tells you how many doses are left.
Croatian: Na stražnjoj strani inhalatora postoji brojač koji pokazuje preostali broj doza.
English: SPECIAL STORAGE CONDITIONS Prior to dispensing:
Croatian: Prije izdavanja:
English: Compared with a fixed combination of beclometasone dipropionate and formoterol, Riarify improved pre-dose FEV1 by 81 mL after 26 weeks of treatment and by 63 mL after 52 weeks of treatment.
Croatian: FEV1 prije doziranja za 81 ml nakon 26 tjedana liječenja te za 63 ml nakon 52 tjedna liječenja.
English: Tremor, dizziness, dysgeusia1, hypoaesthesia1
Croatian: Poremećaji živčanog sustava glavobolja često tremor, omaglica, disgeuzija1, hipoestezija1
English: Pre-dose FEV1
Croatian: FEV1 prije doziranja
English: Excipients
Croatian: POKAZIVAČ
English: A comparison across studies showed that the pharmacokinetics of beclometasone 17-monopropionate, formoterol and glycopyrronium is similar in COPD patients and in healthy subjects.
Croatian: Usporedba različitih ispitivanja pokazala je da je farmakokinetika beklometazon 17-monopropionata,
English: • urinary tract infection.
Croatian: • infekcija mokraćnog sustava.
English: Dysuria, urinary retention, nephritis1
Croatian: Poremećaji bubrega i mokraćnog sustava dizurija, retencija mokraće, nefritis1
English: • painful and frequent urination
Croatian: • bolno i učestalo mokrenje
English: A responder analysis showed that a significantly greater percentage of patients had a clinically significant improvement (reduction versus baseline of greater than or equal to 4) after 26 and 52 weeks with Riarify than with a fixed combination of beclometasone dipropionate and formoterol and with tiotropium.
Croatian: Analiza bolesnika s terapijskim odgovorom pokazala je da je postotak bolesnika s klinički značajnim poboljšanjem (smanjenje veće ili jednako 4 u odnosu na početne vrijednosti) bio značajno veći nakon
English: • tooth decay
Croatian: • upala uha
English: Cough, productive cough1, throat irritation, epistaxis1
Croatian: prsišta i sredoprsja disfonija često kašalj, produktivni kašalj1, nadraženost grla, epistaksa1
English: If you have been prescribed a container providing 60 puffs or 120 puffs There is a counter on the back of the inhaler, which tells you how many doses are left.
Croatian: Ako Vam je propisan spremnik sa 60 ili 120 raspršenih doza
English: Riarify is for inhalation use.
Croatian: Riarify je za primjenu u dišne putove.
English: • numbness
Croatian: • nemir
English: Angina pectoris (stable1 and unstable), ventricular extrasystoles1, nodal rhythm, sinus bradycardia
Croatian: Srčani poremećaji atrijska fibrilacija, elektrokardiografsko produljenje QT intervala, tahikardija, tahiaritmija1, palpitacije manje često angina pektoris (stabilna1 i nestabilna), ventrikularne ekstrasistole1, nodalni ritam, sinusna bradikardija rijetko
English: • diarrhoea
Croatian: • drhtanje
English: Patients with hepatic impairment
Croatian: Bolesnici s oštećenjem funkcije jetre
English: Chiesi Farmaceutici S.p.A. Tel: + 39 0521 2791
Croatian: Merqurio Pharma S.r.l. Tel: + 39 0221116948
English: • headache
Croatian: • suha usta
English: This difference in favour of Galliprant was statistically significant (p-value= 0.0008).
Croatian: Razlika u korist GalliprantA bila je statistički značajna (p-vrijednost = 0,0008).
English: Do not store above 30 °C.
Croatian: Nemojte čuvati pri temperaturi iznad 30 °C.
English: The elimination half-life of grapiprant is approximately 4.6 to 5.67 hours.
Croatian: Poluvrijeme eliminacije za grapiprant iznosi otprilike 4,6 do 5,67 sati.
English: One bottle per cardboard box.
Croatian: Jedna bočica po kartonskoj kutiji.
English: A clinical response to treatment is usually seen within 7 days.
Croatian: Klinički odgovor na liječenje obično je vidljiv unutar 7 dana.
English: The pharmacological activity of the metabolites is not known.
Croatian: Farmakološka aktivnost tih metabolita nije poznata.
English: The veterinary medicinal product is available in the following pack sizes:
Croatian: Veterinarsko-medicinski proizvod dostupan je u sljedećim veličinama pakovanja:
English: Duration of treatment will depend on the response observed to treatment.
Croatian: Trajanje liječenja ovisi o zamijećenom odgovoru na liječenje.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 09/01/2018
Croatian: Datum prvog odobrenja: 09/01/2018
English: CONTENTS BY WEIGHT, BY VOLUME OR BY NUMBER OF DOSES 7 tablets
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI BROJU DOZA 7 tableta
English: Approximately 70-80% of the administered dose is excreted within 48-72 h with the majority of the dose excreted unchanged.
Croatian: Otprilike 70 - 80% primijenjene doze izluči se unutar 4872 sata, s time da se veći dio doze izluči nepromijenjen.
English: Pack sizes of 7 and 30 tablets per bottle.
Croatian: Veličine pakovanja od 7 i 30 tableta po bočici.
English: In case of overdose, symptomatic treatment should be initiated.
Croatian: U slučaju predoziranja potrebno je započeti simptomatsko liječenje.
English: EU/2/17/221/001 (20 mg, 7 tablets, 20 ml bottle) EU/2/17/221/002 (20 mg, 30 tablets, 20 ml bottle) EU/2/17/221/003 (60 mg, 7 tablets, 20 ml bottle) EU/2/17/221/004 (60 mg, 30 tablets, 35 ml bottle) EU/2/17/221/005 (100 mg, 7 tablets, 35 ml bottle) EU/2/17/221/006 (100 mg, 30 tablets, 60 ml bottle)
Croatian: EU/2/17/221/001 (20 mg, 7 tableta, bočica od 20 mL) EU/2/17/221/002 (20 mg, 30 tableta, bočica od 20 mL) EU/2/17/221/003 (60 mg, 7 tableta, bočica od 20 mL) EU/2/17/221/004 (60 mg, 30 tableta, bočica od 35 mL) EU/2/17/221/005 (100 mg, 7 tableta, bočica od 35 mL) EU/2/17/221/006 (100 mg, 30 tableta, bočica od 60 mL)
English: Four metabolites are identified and the metabolic pathways include Ndeamination to form the major metabolite in faeces (7.2%) and urine (3.4%).
Croatian: Utvrđena su četiri metabolita, a metabolički putovi uključuju Ndeaminaciju kojom nastaje glavni metabolit u fecesu (7,2%) i urinu (3,4%).
English: Drug compatibility should be monitored in animals requiring adjunctive therapy.
Croatian: Potrebno je nadzirati kompatibilnost lijekova u životinja koje zahtijevaju primjenu dodatne terapije.
English: Grapiprant does not accumulate in the dog after repeated administration.
Croatian: Grapiprant se ne akumulira u pasa nakon ponavljane primjene.
English: Any half tablets should be stored in the bottle.
Croatian: Polovice tableta potrebno je čuvati u bočici.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains:
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Jedna tableta sadržava:
English: Do not use this veterinary medicinal product after the expiry date, which is stated on the carton and bottle after EXP.
Croatian: Ne koristite veterinarsko-medicinski proizvod poslije isteka roka valjanosti naznačenog na kutiji i bočici poslije EXP.
English: 2.5x and 15x the recommended dose.
Croatian: 2,5 puta i 15 puta višom dozom od preporučene.
English: Shelf-life after first opening of the bottle: 3 months.
Croatian: Rok valjanosti poslije prvog otvaranja bočice: 3 mjeseca.
English: The safety of the veterinary medicinal product has not been established in dogs under 9 months of age and in dogs weighing less than 3.6 kg.
Croatian: Sigurnost primjene veterinarsko-medicinskog proizvoda u pasa mlađih od 9 mjeseci i pasa tjelesne težine manje od 3,6 kg još nije utvrđena.
English: 6.2 Major incompatibilities Not applicable.
Croatian: 6.2 Glavne inkompatibilnosti
English: Administer this veterinary medicinal product on an empty stomach (e.g. in the morning) and at least one hour before the next meal, once daily at a target dose of 2 mg per kg body weight.
Croatian: Veterinarsko-medicinski proizvod primijenite na prazan želudac (npr. ujutro) i najmanje jedan sat prije sljedećeg hranjenja, jedanput dnevno u ciljnoj dozi od 2 mg po kg tjelesne težine.
English: If signs of sulphonamide hypersensitivity occur, treatment should be discontinued.
Croatian: Pojave li se znakovi preosjetljivosti na sulfonamid, liječenje treba prekinuti.
English: If no clinical improvement is apparent after 14 days, treatment with Galliprant should be discontinued and different treatment options should be explored in consultation with the veterinarian.
Croatian: Ako nema vidljivog kliničkog poboljšanja nakon 14 dana, liječenje s Galliprant treba prekinuti i u dogovoru s veterinarom razmotriti druge mogućnosti liječenja.
English: In order to avoid any accidental ingestion, store tablets out of reach of animals.
Croatian: Da bi se izbjegla slučajna ingestija tablete čuvajte izvan dosega životinja.
English: Dose range (mg/kg bw)
Croatian: Raspon doze (mg/kg tt)
English: As field studies were limited to 28 days, longer-term treatment should be considered carefully and regular monitoring undertaken by the veterinarian.
Croatian: Budući da su terenska ispitivanja bila ograničena na 28 dana, odluku o dugotrajnijem liječenju potrebno je donijeti s oprezom uz redoviti veterinarski nadzor.
English: To achieve a substantiated response to treatment, use the veterinary medicinal product only in mild and moderate cases of osteoarthritis.
Croatian: Da bi se postigao značajan odgovor na liječenje, veterinarsko-medicinski proizvod treba primjenjivati samo u slučajevima blagog i umjerenog osteoartritisa.
English: Mild decreases in serum albumin and total protein, most often within the reference range, have been observed in dogs treated with grapiprant but were not associated with any clinically significant observations or events.
Croatian: Blagi pad serumskih vrijednosti albumina i ukupnih proteina, najčešće unutar granica referentnih vrijednosti, opažen je u pasa liječenih grapiprantom, ali to nije bilo povezano ni s kakvim klinički značajnim zapažanjima ili događajima.
English: 4.7 Use during pregnancy, lactation or lay Do not use in pregnant, lactating or breeding animals as the safety of grapiprant has not been established during pregnancy and lactation or in dogs used for breeding.
Croatian: 4.7 Primjena tijekom graviditeta, laktacije ili nesenja Ne primjenjivati na gravidnim i rasplodnim životinjama te onima koje doje jer sigurnost primjene grapipranta tijekom graviditeta i laktacije ili na rasplodnim psima još nije utvrđena.
English: Grapiprant is primarily bound to serum proteins.
Croatian: Grapiprant se prvenstveno vezuje na serumske proteine.
English: The mean percentage of unbound grapiprant was 4.35% and 5.01% at a grapiprant concentration of 200 ng/ml and 1000 ng/ml.
Croatian: Srednja vrijednost postotka nevezanog grapipranta iznosila je 4,35% i 5,01% pri koncentracijama grapipranta od 200 ng/mL odnosno 1000 ng/mL.
English: SPECIAL STORAGE CONDITIONS Do not store above 30 °C.
Croatian: 11. POSEBNI UVJETI ČUVANJA Nemojte čuvati pri temperaturi iznad 30 C.
English: 4.11 Withdrawal period(s) Not applicable.
Croatian: 4.11 Karencija(e) Nije primjenjivo.
English: Use with caution in dogs suffering from pre-existing liver, cardiovascular or renal dysfunctions or from gastrointestinal disease.
Croatian: Primjenjivati s oprezom u pasa koji od ranije boluju od poremećaja funkcije jetre, kardiovaskularnog sustava ili bubrega ili koji boluju od gastrointestinalnih bolesti.
English: Maximum grapiprant concentrations are observed in serum within one hour of dosing in the fasted state.
Croatian: Maksimalna koncentracija grapipranta u serumu zabilježena je unutar jednog sata nakon doziranja natašte.
English: 26 Rue de la Chapelle 68330 Huningue France
Croatian: Elanco France S.A.S. 26 Rue de la Chapelle 68330 Huningue Francuska
English: Grapiprant is readily and rapidly absorbed from the gastrointestinal tract in dogs.
Croatian: Grapiprant se jednostavno i brzo apsorbira iz gastrointestinalnog trakta pasa.
English: Grapiprant is a methylbenzenesulfonamide.
Croatian: Grapiprant je metilbenzensulfonamid.
English: From the two clinical field studies, the overall success rates based on CBPI (Canine Brief Pain Inventory, as completed by the owner) at 28 days after the start of the treatment, were 51.3% (120/235) for Galliprant and 35.5% (82/231) for the placebo group.
Croatian: U dva klinička terenska ispitivanja sveukupna stopa uspješnosti temeljena na CBPI-upitniku (Canine Brief Pain Inventory, kako ga je ispunio vlasnik), 28 dana nakon početka liječenja iznosila je 51,3% (120/235) u skupini Galliprant i 35,5% (82/231) u skupini placebo.
English: Any remaining whole and half tablets should be discarded after 3 months following first opening of the bottle.
Croatian: Sve preostale tablete, bilo cijele ili prepolovljene, treba baciti 3 mjeseca nakon prvog otvaranja bočice.
English: 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary In healthy dogs treated with grapiprant for 9 consecutive months, mild and transient soft-formed or mucous faeces, occasionally bloody, and vomiting were observed at daily overdoses of approximately
Croatian: 4.10 Predoziranje (simptomi, hitni postupci, antidoti), ako je nužno U zdravih pasa liječenih grapiprantom kroz 9 uzastopnih mjeseci opaženi su blaga i prolazna mekano formirana ili sluzava stolica, ponekad krvava i povraćanje pri dnevnom predoziranju s otprilike
English: Two hydroxylated metabolites and one N-oxidated metabolite are also recovered in bile, faeces and/or urine.
Croatian: Utvrđena su također dva hidroksilirana i jedan N-oksidirani metabolit u žuči, fecesu i/ili urinu.
English: The specific effects of the binding of prostaglandin E2 to the EP4 receptor include vasodilation, increased vascular permeability, angiogenesis and production of pro‐inflammatory mediators.
Croatian: Specifični učinci vezivanja prostaglandina E2 na receptore EP4 uključuju vazodilataciju, povećanu vaskularnu permeabilnost, angiogenezu i stvaranje proinflamatornih medijatora.
English: In case of accidental ingestion by children, mild and reversible gastrointestinal signs and nausea may be observed.
Croatian: U slučaju da ga djeca nehotice progutaju, mogu se primijetiti blagi i reverzibilni gastrointestinalni znakovi i mučnina.
English: After a single oral dose of 2 mg grapiprant/kg, Cma x and AUC values of 1.21 µg/ml and 2.71 µg.h/ml were reached in the fasted state.
Croatian: Nakon jedne peroralne doze od 2 mg grapipranta/kg, dostignuta je vrijednost Cma x i AUC od 1,21 µg/mL, odnosno 2,71 µg h/mL natašte.
English: One white HDPE bottle with a child-resistant cap containing 7 or 30 tablets (20 mg, 60 mg or 100 mg tablets).
Croatian: Bijela bočica od HDPE sa zatvaračem koji djeca ne mogu otvoriti koja sadržava 7 ili 30 tableta (tablete od 20 mg, 60 mg ili 100 mg).
English: Any remaining whole and half tablets should be discarded after 3 months following first opening.
Croatian: Sve preostale tablete, bilo cijele ili prepolovljene, treba baciti 3 mjeseca od prvog otvaranja.
English: Do not use in case of hypersensitivity to the active substance or any of the excipients.
Croatian: Ne primjenjivati u slučaju preosjetljivosti na djelatnu tvar ili na bilo koju od pomoćnih tvari.
English: Intake of the tablet with food reduces the oral bioavailability, i.e. the oral bioavailability of grapiprant when taken in the fasted state was 89% and when taken with food it was 33%, with mean Cmax and AUC grapiprant values reduced 4-fold and 2-fold, respectively.
Croatian: Uzimanje tablete s hranom smanjuje bioraspoloživost nakon peroralne primjene, tj. bioraspoloživost nakon peroralne primjene grapipranta natašte bila je 89%, a kada je uzimana s hranom bila je 33%, što znači da su srednje vrijednosti Cmax i AUC grapipranta bile 4 puta, odnosno 2 puta niže.
English: In vitro protein binding of grapiprant indicates that grapiprant is primarily bound to dog serum albumin.
Croatian: Vezivanje grapipranta na proteine in vitro pokazuje da se grapiprant u pasa prvenstveno vezuje na serumske albumine.
English: The concurrent use of grapiprant with other anti-inflammatory agents has not been studied and should be avoided.
Croatian: Istovremena primjena grapipranta i drugih protuupalnih tvari nije ispitana i potrebno ju je izbjegavati.