FrancophonIA/ELRC3.0 huggingface dataset:
English: In a second longer-term study, the efficacy of venlafaxine in prevention of recurrent depressive episodes for a 12-month period was established in a placebo-controlled double-blind clinical trial in adult outpatients with recurrent major depressive episodes who had responded to venlafaxine treatment (100 to 200 mg/day, on a b.i.d.
Slovenian: V drugi dolgoročnejši raziskavi so dokazali učinkovitost venlafaksina za preprečevanje ponovitev depresivnih epizod v 12-mesečni, dvojno slepi, s placebom nadzorovani klinični raziskavi, izvedeni pri ambulantno zdravljenih, odraslih bolnikih s ponovljenimi hudimi depresivnimi epizodami, ki so se med zadnjo depresivno epizodo odzvali na zdravljenje z venlafaksinom (100 do 200 mg/dan, razdeljenih v dva ločena odmerka).
English: Side effects are known to occur when people stop using Efexor, especially when Efexor is stopped suddenly or the dose is reduced too quickly.
Slovenian: Pri prekinitvi zdravljenja z zdravilom Efexor se pojavijo neželeni učinki, še posebej pri nenadni ukinitvi zdravila Efexor ali pri prehitrem zniževanju odmerka.
English: Common: difficulties passing urine; increased frequency in urination Uncommon: inability to pass urine
Slovenian: Pogosti: oteženo uriniranje; pogostnejše uriniranje Občasni: zastoj urina
English: SPC Section 4.2 - Posology and Method of Administration The MAH was asked to harmonize the following posology texts in the SPC: - limitations of treatment duration of the maximum daily dose of 375mg to 4 weeks; - differences in maximum recommended daily dose.
Slovenian: Povzetek glavnih značilnosti zdravila, poglavje 4.2: Odmerjanje in način uporabe Imetnik dovoljenja za promet z zdravilom je bil naprošen, da uskladi naslednja besedila o odmerjanjih v povzetku glavnih značilnosti zdravila: - omejitev trajanja zdravljenja z največjim dnevnim odmerkom 375 mg na 4 tedne; - razlike v največjih priporočenih dnevnih odmerkih.
English: The following symptoms may be observed in neonates if the mother has used an SSRI/SNRI late in pregnancy: irritability, tremor, hypotonia, persistent crying, and difficulty in sucking or in sleeping.
Slovenian: Če mati uporablja SSRI/SNRI v pozni nosečnosti, se lahko pri novorojenčku opazi naslednje simptome: razdražljivost, tremor, hipotonija, vztrajen jok in težave pri sesanju ali nespečnost.
English: Signs and symptoms of serotonin syndrome may include a combination of the following: restlessness, hallucinations, loss of coordination, fast heart beat, increased body temperature, fast changes in blood pressure, overactive reflexes, diarrhoea, coma, nausea, vomiting.
Slovenian: Znaki in simptomi serotoninskega sindroma lahko vključujejo kombinacijo sledečega: nemir, halucinacije, motnje koordinacije, pospešen srčni utrip, povišana telesna temperatura, hitre spremembe krvnega tlaka, pretirane refleksne reakcije, driska, koma, siljenje na bruhanje ali bruhanje.
English: Therefore, you should discuss the matter with your doctor, and he/she will decide whether you should stop breast-feeding or stop the therapy with Efexor.
Slovenian: Potrebno se je posvetovati z vašim zdravnikom, ki bo presodil, ali boste prenehali dojiti ali prenehali z zdravljenjem z zdravilom Efexor.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION {DD/MM/YYYY} [To be completed nationally]
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET {DD/MM/LLLL} [Izpolni država članica.]
English: Efexor may cause a sensation of restlessness or an inability to sit or stand still.
Slovenian: Zdravilo Efexor lahko povzroči občutek nemira ali nezmožnost mirnega sedenja ali stanja.
English: SPC Section 4.1 - Therapeutic Indications
Slovenian: 4.1 Terapevtske indikacije
English: If you forget to take Efexor
Slovenian: Če ste pozabili vzeti zdravilo Efexor
English: Do not start or stop taking any medicines, including those bought without a prescription, natural and herbal remedies, before checking with your doctor or pharmacist.
Slovenian: Brez predhodnega posveta z zdravnikom ali s farmacevtom ne smete začeti jemati ali prenehati z jemanjem kateregakoli zdravila, vključno s tistimi, ki ste jih kupili brez recepta ter naravnimi in zeliščnimi zdravili.
English: Efexor is an antidepressant that belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors (SNRIs).
Slovenian: Zdravilo Efexor je antidepresiv, ki spada v skupino zdravil, ki se imenujejo zaviralci ponovnega privzema serotonina in noradrenalina (SNRI).
English: Venlafaxine is not indicated for weight loss alone or in combination with other products.
Slovenian: Venlafaksin ni indiciran za hujšanje, niti samostojno niti v kombinaciji z drugimi zdravili.
English: Some patients may experience symptoms such as tiredness, dizziness, light-headedness, headache, sleeplessness, nightmares, dry mouth, loss of appetite, nausea, diarrhoea, nervousness, agitation, confusion, ringing in the ears, tingling or rarely, electric shock sensations, weakness, sweating, seizures or flu-like symptoms.
Slovenian: Pri nekaterih bolnikih se lahko pojavijo simptomi, kot so utrujenost, vrtoglavica, omotica, glavobol, nespečnost, nočne more, suha usta, neješčnost, siljenje na bruhanje, driska, živčnost, vznemirjenost, zmedenost, zvonjenje v ušesih, mravljinčenje in redko občutki električnega udarca, oslabelost, znojenje, epileptični napadi ali gripi podobni simptomi.
English: the CHMP has recommended the amendment of the Marketing Authorisations for which the Summary of Product Characteristics, labelling and package leaflet are set out in Annex III for Efexor and associated names (see Annex I).
Slovenian: je Odbor za zdravila za uporabo v humani medicini priporočil dopolnilo dovoljenj za promet z zdravilom Efexor in z njim povezanih imen, za katera so v Dodatku III določeni povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo (glejte Dodatek I).
English: Effect of other medicinal products on venlafaxine
Slovenian: Delovanje drugih zdravil na venlafaksin
English: Very common Affects more than 1 user in 10 Common
Slovenian: Pojavljajo se pri več kot 1 bolniku od 10.
English: For example, venlafaxine immediate-release tablets 37.5 mg twice daily may be switched to venlafaxine prolonged-release capsules 75 mg once daily.
Slovenian: Tako lahko na primer bolnik, ki jemlje eno 37,5-miligramsko tableto venlafaksina s takojšnjim sproščanjem dvakrat na dan, preide na eno 75-miligramsko kapsulo venlafaksina s podaljšanim sproščanjem enkrat na dan.
English: Very common: nausea
Slovenian: Zelo pogosti: siljenje na bruhanje
English: Severe adverse reactions have been reported in patients who have recently been discontinued from an MAOI and started on venlafaxine, or have recently had venlafaxine therapy discontinued prior to initiation of an MAOI.
Slovenian: Pri bolnikih, ki so nedavno prenehali jemati zaviralce MAO in začeli zdravljenje z venlafaksinom, ali pri tistih, ki so nedavno prekinili zdravljenje z venlafaksinom in začeli zdravljenje z zaviralci MAO, so poročali o resnih neželenih učinkih.
English: Aggression may occur in a small number of patients who have received antidepressants, including venlafaxine.
Slovenian: Pri majhnem številu bolnikov, ki se zdravijo z antidepresivi, vključno z venlafaksinom, se lahko pojavi agresivnost.
English: • Haloperidol or risperidone (to treat psychiatric conditions)
Slovenian: • haloperidol ali risperidon (za zdravljenje motenj razpoloženja),
English: No specific dose adjustments of venlafaxine are considered necessary based on patient age alone.
Slovenian: Posebno prilagajanje odmerka venlafaksina zaradi starosti ni potrebno.
English: However, the CHMP considered that only non-selective, irreversible MAOIs should be contraindicated and that a strong warning in Section 4.4 and Section 4.5 of the SPC should be sufficient for the reversible MAOIs.
Slovenian: Kljub temu pa je CHMP menil, da je kot kontraindicirane treba navesti samo neselektivne, ireverzibilne zaviralce monoaminskih oksidaz ter da naj bi opozorilo v poglavjih 4.4 in 4.5 povzetka glavnih značilnosti zdravila zadostovalo za reverzibilne zaviralce monoaminske oksidaze.
English: The same precautions observed when treating patients with major depressive disorder should therefore be observed when treating patients with other psychiatric disorders.
Slovenian: Med zdravljenjem bolnikov z drugimi psihiatričnimi motnjami je torej treba izvajati enake previdnostne ukrepe kot med zdravljenjem bolnikov s hudo depresivno motnjo.
English: In paediatric clinical trials the adverse reaction suicidal ideation was observed.
Slovenian: V kliničnih raziskavah pri otrocih so poročali o samomorilnem mišljenju.
English: The human relevance of this finding is unknown.
Slovenian: Klinični pomen te ugotovitve za človeka ni znan.
English: The frequency (likelihood of occurring) of side effects is classified as follows:
Slovenian: verjetnost, da se bodo pojavili) je sledeča:
English: Venlafaxine and its active metabolite, O-desmethylvenlafaxine, are excreted in breast milk.
Slovenian: Venlafaksin in njegov aktivni presnovek O-demetilvenlafaksin se izločata v materino mleko.
English: The antibiotic linezolid is a weak reversible and non-selective MAOI and should not be given to patients treated with venlafaxine (see section 4.4).
Slovenian: Reverzibilen, neselektiven zaviralec MAO (linezolid) Antibiotika linezolida, ki je šibek, reverzibilen, neselektiven zaviralec MAO, bolniki, zdravljeni z venlafaksinom, ne smejo prejemati (glejte poglavje 4.4).
English: Plasma concentrations of venlafaxine are higher in CYP2D6 poor metabolisers than extensive metabolisers.
Slovenian: Plazemske koncentracije venlafaksina so višje pri osebah z upočasnjeno presnovo preko CYP2D6 kot pri tistih z obsežno presnovo preko CYP2D6.
English: SPC Section 4.4 - Special Warnings and Precautions for Use The MAH was asked to harmonize Section 4.4, for which the following differences between SPCs needed to be evaluated: - the mentioning of reports of aggression in relation to starting and discontinuing treatment; - treatment of children and adolescents under the age of 18, which was recommended by the CHMP in 2005 to be included in Section 4.4 of the SPC (Commission Decision of 19-VIII-2005); With regards to the aggression reports, it was agreed to introduce a wording to indicate that aggression may occur in patients receiving venlafaxine, under initiation, dose changes and discontinuation of treatment.
Slovenian: Povzetek glavnih značilnosti zdravila, poglavje 4.4: Posebna opozorila in previdnostni ukrepi Imetnik dovoljenja za promet z zdravilom je bil naprošen, da uskladi poglavje 4.4, v katerem je treba oceniti naslednja neskladja med povzetki glavnih značilnosti zdravila: - omemba poročil o agresivnosti, povezani z začetkom ali prekinitvijo jemanja zdravila; - zdravljenje otrok in mladostnikov, mlajših od 18 let; CHMP je leta 2005 priporočil, da se to vključi v poglavje 4.4 povzetka glavnih značilnosti zdravila (Sklep Komisije z dne 19. 8. 2005).
English: If you stop taking Efexor
Slovenian: Če ste prenehali jemati zdravilo Efexor
English: It is therefore advised that when venlafaxine treatment is no longer required, gradual discontinuation by dose tapering should be carried out (see sections 4.2 and 4.4).
Slovenian: Ko zdravljenje z venlafaksinom ni več potrebno, je priporočljivo postopno ukinjanje zdravila s postopnim zmanjševanjem odmerka (glejte poglavji 4.2 in 4.4).
English: As with all antidepressants, venlafaxine should be introduced with caution in patients with a history of convulsions, and concerned patients should be closely monitored.
Slovenian: Podobno kot vse druge antidepresive, je treba tudi venlafaksin pri bolnikih s konvulzijami v anamnezi uvesti previdno, takšne bolnike pa skrbno spremljati.
English: You should avoid alcohol while you are taking Tradename.
Slovenian: Med zdravljenjem z zdravilom Efexor se morate izogibati pitju alkoholnih pijač.
English: Efexor should not be used in the treatment of children and adolescents under the age of 18 years.
Slovenian: Zdravila Efexor se ne sme uporabljati pri otrocih in mladostnikih, mlajših od 18 let.
English: Take special care with Efexor
Slovenian: Bodite posebno pozorni pri uporabi zdravila Efexor
English: The efficacy of venlafaxine immediate-release as a treatment for major depressive episodes was demonstrated in five randomised, double-blind, placebo-controlled, short-term trials ranging from 4 to 6 weeks duration, for doses up to 375 mg/day.
Slovenian: Učinkovitost venlafaksina s takojšnjim sproščanjem pri zdravljenju hudih depresivnih epizod je bila dokazana v petih randomiziranih, dvojno slepih, s placebom nadzorovanih kratkoročnih raziskavah, ki so trajale od 4 do 6 tednov, za odmerke do 375 mg/dan.
English: Suicide-related behaviours (suicide attempt and suicidal thoughts) and hostility (predominantly aggression, oppositional behaviour and anger) were more frequently observed in clinical trials among children and adolescents treated with antidepressants compared to those treated with placebo.
Slovenian: Pri otrocih in mladostnikih, ki so se zdravili z antidepresivi, so v kliničnih preskušanjih pogosteje opažali samomorilno vedenje (poskus samomora in samomorilne misli) ter sovražno vedenje (predvsem agresivnost, uporniško vedenje in jezo) kot pri tistih, ki so prejemali placebo.
English: Therefore, a decision to continue/discontinue breast-feeding or to continue/discontinue therapy with Efexor should be made, taking into account the benefit of breast-feeding to the child and the benefit of Efexor therapy to the woman.
Slovenian: Potrebno je pretehtati korist dojenja za otroka in korist zdravljenja z zdravilom Efexor za mater in na podlagi tega sprejeti odločitev o nadaljevanju ali prekinitvi dojenja in nadaljevanju ali prekinitvi zdravljenja z zdravilom Efexor.
English: • Heart or circulation disorders
Slovenian: • Bolezni srca in krvnega obtoka
English: Do not stop taking your treatment or reduce the dose without the advice of your doctor even if you feel better.
Slovenian: Kljub morebitnemu boljšemu počutju, zdravila brez nasveta zdravnika ne smete prenehati jemati niti znižati odmerka.
English: The symptoms of a possible overdose may include a rapid heart beat, changes in level of alertness (ranging from sleepiness to coma), blurred vision, seizures or fits, and vomiting.
Slovenian: Simptomi možnega prevelikega odmerka lahko vključujejo pospešen srčni utrip, spremembe stanja zavesti (od zaspanosti do globoke nezavesti), zamegljen vid, epileptične napade in bruhanje.
English: Frequency cannot be estimated from the available data • Blood disorders
Slovenian: Pogostnosti iz razpoložljivih podatkov ni mogoče oceniti.
English: These reactions have included tremor, myoclonus, diaphoresis, nausea, vomiting, flushing, dizziness, and hyperthermia with features resembling neuroleptic malignant syndrome, seizures, and death.
Slovenian: Ti neželeni učinki so vključevali tremor, mioklonus, čezmerno znojenje, navzeo, bruhanje, zardevanje, omotico in hipertermijo z značilnostmi, podobnimi malignemu nevroleptičnemu sindromu, epileptične napade in smrt.
English: • Medicines containing sibutramine (used for weight loss)
Slovenian: • zdravila, ki vsebujejo sibutramin (uporablja se za hujšanje);
English: In general, the adverse reaction profile of venlafaxine (in placebo-controlled clinical trials) in children and adolescents (ages 6 to 17) was similar to that seen for adults.
Slovenian: Pri otrocih in mladostnikih (starih 6 do 17 let) je profil neželenih učinkov venlafaksina (v s placebom nadzorovanih kliničnih raziskavah) na splošno podoben kot pri odraslih.
English: In vitro and in vivo studies indicate that venlafaxine is biotransformed to its major active metabolite, ODV, by CYP2D6.
Slovenian: Raziskave in vitro in in vivo kažejo, da se venlafaksin presnavlja v svoj glavni aktivni presnovek ODV s pomočjo izoencima CYP2D6.
English: • Nerve problems, such as dizziness, pins and needles, movement disorder, seizures or fits
Slovenian: • težave z živci, na primer mravljinčenje ali pekoč občutek, motnje gibanja, epileptični napadi in nezavest;
English: • Medicines containing moclobemide, a reversible MAOI (used to treat depression)
Slovenian: • zdravila, ki vsebujejo moklobemid, reverzibilen zaviralec MAO (uporablja se za zdravljenje depresije);
English: Common: abnormal dreams; decreased libido; dizziness; increased muscle tonus; insomnia; nervousness; pins and needles; sedation; tremor; confusion; feeling separated (or detached) from yourself and reality
Slovenian: Pogosti: nenormalne sanje; zmanjšan libido; omotica; povečan mišični tonus; nespečnost; živčnost; mravljinčenje ali pekoč občutek; sedacija; tresenje; zmedenost; občutek razdvojenosti od samega sebe in realnosti
English: Pulmonary eosinophilia
Slovenian: Dihala zehanje pljučna eozinofilija
English: As with other serotonergic agents, serotonin syndrome may occur with venlafaxine treatment, particularly with concomitant use of other agents that may affect the serotonergic neurotransmitter system (including triptans, SSRIs, SNRIs, lithium, sibutramine, tramadol, or St. John's Wort [Hypericum perforatum]), with medicinal agents which impair metabolism of serotonin (including MAOIs), or with serotonin precursors (such as tryptophan supplements).
Slovenian: Kot pri drugih serotoninergičnih zdravilih, se lahko tudi pri zdravljenju z venlafaksinom pojavi serotoninski sindrom, še posebej pri sočasni uporabi drugih zdravil, ki lahko vplivajo na serotoninergični nevrotransmiterski sistem (vključno s triptani, selektivnimi zaviralci privzema serotonina (SSRI, selective serotonin reuptake inhibitors), zaviralci privzema serotonina-noradrenalina (SNRI, serotonin noradrenalin reuptake inhibitors), litijem, sibutraminom, tramadolom in šentjanževko (Hypericum perforatum), zdravili, ki vplivajo na presnovo serotonina (vključno z zaviralci MAO) ali prekurzorji serotonina (kot so nadomestki triptofana).
English: Cases of hyponatraemia and/or the Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion may occur with venlafaxine.
Slovenian: Pri zdravljenju z venlafaksinom se lahko pojavi hiponatriemija in/ali sindrom neustreznega izločanja antidiuretskega hormona (SIADH, Syndrome of Inappropriate Antidiuretic Hormone).
English: • Chest tightness, wheezing, trouble swallowing or breathing
Slovenian: • stiskanje v prsih, sopenje, težave pri požiranju ali dihanju;
English: United Kingdom John Wyeth & Brother Limited, Huntercombe Lane South, Taplow, Maidenhead, Berkshire SL6 0PH United Kingdom
Slovenian: Velika Britanija John Wyeth & Brother Limited, Huntercombe Lane South, Taplow, Maidenhead, Berkshire SL6 0PH Velika Britanija
English: The efficacy of venlafaxine prolonged-release as a treatment for major depressive episodes was established in two placebo-controlled, short-term studies for 8 and 12 weeks duration, which included a dose range of 75 to 225 mg/day.
Slovenian: Učinkovitost venlafaksina s podaljšanim sproščanjem pri zdravljenju hudih depresivnih epizod je bila dokazana v dveh, s placebom nadzorovanih, kratkoročnih raziskavah, ki sta trajali od 8 do 12 tednov, odmerki pa so bili v razponu od 75 do 225 mg/dan.
English: It is therefore advised that venlafaxine should be gradually tapered when discontinuing treatment over a period of several weeks or months, according to the patient's needs (see section 4.2).
Slovenian: V primeru prekinitve zdravljenja je zato priporočljivo postopno zmanjševanje odmerkov, ki naj glede na bolnikove potrebe traja več tednov ali mesecev (glejte poglavje 4.2).
English: Venlafaxine does not possess monoamine oxidase (MAO) inhibitory activity.
Slovenian: Venlafaksin ni zaviralec monoaminooksidaz (MAO).
English: The MAH wished to maintain that all MAOIs should be contraindicated whereas the CHMP considered that only non-selective, irreversible MAOIs should be contraindicated and that a strong warning in Section 4.5 of the SPC should be sufficient for the reversible MAOIs.
Slovenian: Imetnik dovoljenja za promet z zdravilom je menil, da je treba obdržati kontraindikacijo za vse zaviralce monoaminskih oksidaz, medtem ko je CHMP menil, da je treba kontraindicirati samo neselektivne, ireverzibilne zaviralce monoaminskih oksidaz ter da za reverzibilne zaviralce monoaminskih oksidaz zadostuje opozorilo v poglavju 4.5 povzetka glavnih značilnosti zdravila.
English: • Products containing tryptophan (used for problems such as sleep and depression)
Slovenian: • pripravki, ki vsebujejo triptofan (uporabljajo se pri motnjah spanja in depresiji).
English: Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine.
Slovenian: Metoprolol ni spremenil farmakokinetičnega profila venlafaksina ali njegovega aktivnega presnovka O-demetilvenlafaksina.
English: Use in patients with hepatic impairment: it was agreed to recommend in the SPC the individualization of dosage to overcome clearance variability between patients with hepatic impairment.
Slovenian: Uporaba pri bolnikih z okvaro jeter: sprejeto je bilo, da se v povzetku glavnih značilnosti zdravila priporoči določanje odmerka za vsakega bolnika posebej, saj se le tako lahko uskladi razlike glede izločanja zdravila pri bolnikih z okvaro jeter.
English: Gastric lavage may be indicated if performed soon after ingestion or in symptomatic patients.
Slovenian: Izpiranje želodca je indicirano, če ga je mogoče izvesti kmalu po zaužitju in pri simptomatskih bolnikih.
English: Common: abnormal ejaculation/orgasm (males); lack of orgasm; erectile dysfunction (impotence); menstrual irregularities such as increased bleeding or increased irregular bleeding Uncommon: abnormal orgasm (females)
Slovenian: Pogosti: motnje ejakulacije/orgazma (moški); nezmožnost doživeti orgazem; erektilna disfunkcija (impotenca); menstrualne nepravilnosti, kot so močnejše krvavitve ali močnejše neredne krvavitve
English: Therefore, caution is advised if a patient's therapy includes a CYP3A4 inhibitor and venlafaxine concomitantly.
Slovenian: Pri bolnikih, ki se sočasno zdravijo z zaviralcem CYP3A4 in venlafaksinom, je zato priporočljiva previdnost.
English: Treatment should be discontinued in any patient who develops seizures.
Slovenian: Pri vsakem bolniku, pri katerem se pojavijo konvulzije, je treba zdravljenje prekiniti.
English: Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhoea).
Slovenian: Simptomi serotoninskega sindroma lahko vključujejo spremembe duševnega stanja (npr. agitacijo, halucinacije, komo), avtonomno nestabilnost (npr. tahikardijo, spremenljiv krvni tlak, povišano telesno temperaturo), živčnomišične motnje (npr. hiperrefleksijo, motnje koordinacije) in/ali prebavne simptome (npr. navzejo, bruhanje, drisko).
English: Reversible, selective MAO-A inhibitor (moclobemide) Due to the risk of serotonin syndrome, the combination of venlafaxine with a reversible and selective MAOI, such as moclobemide, is not recommended.
Slovenian: Reverzibilen, selektiven zaviralec MAO-A (moklobemid) Kombinacija venlafaksina z reverzibilnim selektivnim zaviralcem MAO, kot je moklobemid, ni priporočljiva zaradi tveganja za pojav serotoninskega sindroma.
English: Venlafaxine is extensively metabolised, primarily to the active metabolite, O-desmethylvenlafaxine (ODV).
Slovenian: Venlafaksin se obsežno presnavlja, predvsem v aktivni presnovek O-demetilvenlafaksin (ODV).
English: Venlafaxine has no effects on the pharmacokinetics and pharmacodynamics of diazepam and its active metabolite, desmethyldiazepam.
Slovenian: Venlafaksin ne vpliva na farmakokinetiko in farmakodinamiko diazepama in njegovega aktivnega presnovka demetildiazepama.
English: It is recommended that venlafaxine should be discontinued for at least 7 days before starting treatment with a reversible MAOI (see section 4.4).
Slovenian: Priporočljivo je, da se venlafaksin ukine vsaj 7 dni pred začetkom zdravljenja z reverzibilnim zaviralcem MAO (glejte poglavje 4.4).