FrancophonIA/ELRC3.0 huggingface dataset:
English: What Atacand Plus is and what it is used for Before you take Atacand Plus How to take Atacand Plus Possible side effects
Slovenian: Kaj je zdravilo Atacand Plus in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Atacand Plus Kako jemati zdravilo Atacand Plus Možni neželeni učinki
English: Damage to blood vessels causing red or purple dots in the skin.
Slovenian: • Prizadetost žil, ki povzroči rdeče ali vijoličaste pege na koži.
English: When Atacand Plus is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid levels is recommended.
Slovenian: Med uporabo zdravila Atacand Plus pri bolnikih z okvarjenim delovanjem ledvic so priporočljive redne kontrole kalija, kreatinina in sečne kisline.
English: Respiratory infection.
Slovenian: • Okužba dihal.
English: Concomitant administration of candesartan cilexetil and hydrochlorothiazide has no clinically significant effect on the pharmacokinetics of either medicinal product.
Slovenian: Sočasna uporaba cileksetilkandesartanata in hidroklorotiazida ni klinično pomembno vplivala na farmakokinetiko enega ali drugega zdravila.
English: Foetotoxicity has been observed in late pregnancy with candesartan.
Slovenian: Pri kandesartanu so med pozno nosečnostjo opažali fetotoksičnost.
English: Medicines to lower your cholesterol, such as colestipol or cholestyramine.
Slovenian: • Zdravila za znižanje holesterola, npr. holestipol ali holestiramin.
English: The antagonism of the AT1 receptors results in dose related increases in plasma renin levels, angiotensin I and angiotensin II levels, and a decrease in plasma aldosterone concentration.
Slovenian: Posledica antagonizma na receptorjih AT1 je z odmerkom povezano povečanje plazemske koncentracije renina, angiotenzina I in angiotenzina II ter zmanjšanje plazemske koncentracije aldosterona.
English: Patients with primary hyperaldosteronism generally will not respond to antihypertensive agents acting through inhibition of the renin-angiotensin-aldosterone system.
Slovenian: Bolniki s primarnim aldosteronizmom se praviloma ne odzovejo na antihipertenzivna zdravila, ki zavirajo sistem renin-angiotenzin-aldosteron.
English: Based on pharmacological considerations, the main manifestation of an overdose of candesartan cilexetil is likely to be symptomatic hypotension and dizziness.
Slovenian: Na podlagi farmakologije sta najverjetnejša glavna znaka prevelikega odmerjanja cileksetilkandesartanata simptomatska hipotenzija in omotica.
English: If the combination proves necessary, careful monitoring of serum lithium levels is recommended.
Slovenian: Če je takšna kombinacija potrebna, je priporočljivo natančno kontrolirati koncentracijo litija v serumu.
English: Some of the side effects of Atacand Plus are caused by candesartan cilexetil and some are caused by hydrochlorothiazide.
Slovenian: Nekatere neželene učinke zdravila Atacand Plus povzroči cileksetilkandesartanat, nekatere pa hidroklorotiazid.
English: Refractory hypokalaemia and hypercalcaemia.
Slovenian: Refraktarna hipokaliemija in hiperkalciemija.
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Slovenian: Dojenčke mater, ki so prejemale ARAII, je treba natančno kontrolirati glede hipotenzije (glejte tudi poglavji 4.3 in 4.4).
English: The bioavailability may decrease in patients with cardiac failure and pronounced oedema.
Slovenian: Biološka uporabnost se lahko zmanjša pri bolnikih s srčnim popuščanjem in izrazitimi edemi.
English: In preclinical safety studies candesartan itself had effects on the kidneys and on red cell parameters at high doses in mice, rats, dogs and monkeys.
Slovenian: V predkliničnih študijah varnosti so veliki odmerki kandesartana samega pri miših, podganah, psih in opicah vplivali na ledvice in eritrocitne parametre.
English: Rare (affects less than 1 user in 1,000)
Slovenian: Zelo redki (pojavijo se pri manj kot 1 bolniku od 10.000 bolnikov)
English: Exposure to AIIRA therapy during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see section 5.3).
Slovenian: Znano je, da ima izpostavljenost ARAII v drugem in tretjem trimesečju pri človeku toksične učinke na plod (zmanjšano delovanje ledvic, oligohidramnij, zapoznela osifikacija lobanje) in novorojenčka (odpoved ledvic, hipotenzija, hiperkaliemija) (glejte poglavje 5.3).
English: The terminal half-life (t½) of candesartan is approximately 9 hours.
Slovenian: Terminalni razpolovni čas (t1/2) kandesartana je približno 9 ur.
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypercalcaemia, hypokalaemia, hyponatraemia, hypomagnesaemia and hypochloraemic alkalosis).
Slovenian: Tiazidi, vključno s hidroklorotiazidom, lahko povzročijo neravnovesje tekočine ali elektrolitov (hiperkalciemijo, hipokaliemijo, hiponatriemijo, hipomagneziemijo in hipokloremično alkalozo).
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Slovenian: Zdravljenje z ARAII je treba končati takoj po ugotovitvi nosečnosti in uvesti drugo zdravljenje, če je to primerno (glejte poglavji 4.3 in 4.6).
English: Hydrochlorothiazide The terminal t½ of hydrochlorothiazide is prolonged in patients with renal impairment.
Slovenian: Hidroklorotiazid Terminalni t1/2 hidroklorotiazida je pri bolnikih z okvaro ledvic podaljšan.
English: Thiazide may increase the risk of adverse effects caused by amantadine.
Slovenian: Tiazidi lahko povečajo tveganje neželenih učinkov amantadina.
English: Tingling or prickling in your arms or legs.
Slovenian: • Mravljinčenje v rokah ali nogah.
English: It contains two active ingredients: candesartan cilexetil and hydrochlorothiazide.
Slovenian: Vsebuje dve zdravilni učinkovini: cileksetilkandesartanat in hidroklorotiazid.
English: Dose titration with the individual components (candesartan cilexetil and hydrochlorothiazide) is recommended.
Slovenian: Priporočljivo je titriranje odmerka s posameznima sestavinama (cileksetilkandesartanatom in hidroklorotiazidom).
English: Concomitant use of Atacand Plus and potassium-sparing diuretics, potassium supplements or salt substitutes or other medicinal products that may increase serum potassium levels (e.g. heparin sodium) may lead to increases in serum potassium.
Slovenian: Sočasna uporaba zdravila Atacand Plus in diuretikov, ki varčujejo s kalijem, dodatkov kalija, nadomestkov soli ali drugih zdravil, ki lahko povečajo koncentracijo kalija v serumu (npr. natrijevega heparinata), lahko hipertenzivnim bolnikom poveča koncentracije kalija v serumu.
English: Thiazide diuretics may decrease the urinary calcium excretion and may cause intermittent and slightly increased serum calcium concentrations.
Slovenian: Tiazidni diuretiki lahko zmanjšajo izločanje kalcija v urinu in lahko povzročijo intermitentno in rahlo povečanje koncentracije kalcija v serumu.
English: Your doctor may prescribe Atacand Plus if your blood pressure has not been properly controlled by candesartan cilexetil or hydrochlorothiazide alone.
Slovenian: Zdravnik vam lahko predpiše zdravilo Atacand Plus, če vam krvnega tlaka ni bilo mogoče ustrezno urediti s samim cileksetilkandesartanatom ali hidroklorotiazidom.
English: Amphotericin (for the treatment of fungal infections).
Slovenian: • Amfotericin (za zdravljenje glivičnih okužb).
English: In clinical trials with candesartan cilexetil/hydrochlorothiazide, adverse reactions were limited to those that were reported previously with candesartan cilexetil and/or hydrochlorothiazide.
Slovenian: V kliničnih preskušanjih s cileksetilkandesartanatom/hidroklorotiazidom so bili neželeni učinki omejeni na tiste, ki so bili že pred tem opisani s cileksetilkandesartanatom in/ali hidroklorotiazidom.
English: • Class III antiarrhythmics (e.g. amiodarone, sotalol, dofetilide, ibutilide)
Slovenian: • antiaritmiki iz skupine III (kot so npr. amiodaron, sotalol, dofetilid, ibutilid).
English: In a pooled analysis of clinical trial data of hypertensive patients, adverse reactions with candesartan cilexetil were defined based on an incidence of adverse events with candesartan cilexetil at least 1% higher than the incidence seen with placebo.
Slovenian: V skupni analizi podatkov kliničnih preskušanj pri hipertenzivnih bolnikih so bili neželeni učinki s cileksetilkandesartanatom opredeljeni kot incidenca neželenih učinkov s cileksetilkandesartanatom, vsaj 1 % večja od tiste s placebom.
English: This is because Atacand Plus, when combined with some anaesthetics, may cause a drop in blood pressure.
Slovenian: V kombinaciji z nekaterimi anestetiki namreč zdravilo Atacand Plus lahko povzroči padec krvnega tlaka.
English: you have persistently low levels of potassium in your blood.
Slovenian: - če imate trajno nizek kalij v krvi.
English: Candesartan and hydrochlorothiazide both show genotoxic activity at very high concentrations/doses.
Slovenian: Kandesartan in hidroklorotiazid v zelo velikih koncentracijah/odmerkih oba delujeta genotoksično.
English: In patients with mild to moderate renal impairment, Cmax and AUC of candesartan increased during repeated dosing by approximately 50% and 70%, respectively, but the terminal t½ was not altered, compared to patients with normal renal function.
Slovenian: Pri bolnikih z blago do zmerno okvaro ledvic sta se Cmax in AUC kandesartana med večkratnim odmerjanjem povečali za približno 50 % (Cmax) in 70 % (AUC), terminalni t1/2 pa se ni spremenil v primerjavi z bolniki z normalnim delovanjem ledvic.
English: In individual case reports of overdose (of up to 672 mg candesartan cilexetil) patient recovery was uneventful.
Slovenian: Opisani so posamezni primeri prevelikega odmerjanja (do 672 mg cileksetilkandesartanata).
English: Atacand Plus is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Slovenian: Če želite dojiti, vam bo zdravnik najbrž izbral drugo zdravilo, še zlasti če je vaš otrok novorojenček ali je bil rojen prezgodaj.
English: Metformin should be used with caution because of the risk of lactic acidosis induced by possible functional renal failure linked to hydrochlorothiazide.
Slovenian: Metformin je treba uporabljati previdno: zaradi možne funkcijske odpovedi ledvic, povezane s hidroklorotiazidom, namreč obstaja tveganje laktacidoze.
English: Atacand Plus is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Slovenian: Če ste noseči več kot 3 mesece, pa ga sploh ne smete jemati, kajti njegovo jemanje po tretjem mesecu nosečnosti lahko otroku resno škoduje.
English: The use of Atacand Plus during breast-feeding is not recommended.
Slovenian: Uporaba zdravila Atacand Plus med obdobjem dojenja ni priporočljiva.
English: Periodic determination of serum electrolytes should be performed at appropriate intervals.
Slovenian: V ustreznih presledkih so potrebne redne kontrole elektrolitov v serumu.
English: Atacand Plus is contraindicated in patients with severe renal impairment (creatinine clearance < 30 ml/min/1.73 m2 BSA) (see section 4.3).
Slovenian: Zdravilo Atacand Plus je kontraindicirano pri bolnikih s hudo okvaro ledvic (očistek kreatinina < 30 ml/min/1,73 m2 telesne površine) (glejte poglavje 4.3).
English: Diuretic-induced hypokalaemia and hypomagnesaemia predisposes to the potential cardiotoxic effects of digitalis glycosides and antiarrhythmics.
Slovenian: Z diuretiki povzročena hipokaliemija in hipomagneziemija povečujeta nagnjenost h kardiotoksičnim učinkom digitalisnih glikozidov in antiaritmičnih zdravil.
English: The potassium depleting effect of hydrochlorothiazide could be expected to be potentiated by other medicinal products associated with potassium loss and hypokalaemia (e.g. other kaliuretic diuretics, laxatives, amphotericin, carbenoxolone, penicillin G sodium, salicylic acid derivates, steroids, ACTH).
Slovenian: Hidroklorotiazid izplavlja kalij in ta učinek lahko stopnjuje sočasna uporaba drugih zdravil, ki jih spremljata izgubljanje kalija in hipokaliemija (npr. drugih kaliuretičnih diuretikov, odvajal, amfotericina, karbenoksolona, natrijevega benzilpenicilinata, derivatov salicilne kisline, steroidov, ACTH).
English: Steroids such as prednisolone.
Slovenian: • Steroide, npr. prednizolon.
English: Should exposure to AIIRAs have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Slovenian: Če od drugega trimesečja nosečnosti naprej pride do izpostavljenosti ARAII, je priporočljivo z ultrazvokom preveriti delovanje ledvic in lobanjo.
English: If you forget to take use Atacand Plus Do not take a double dose to make up for a forgotten tablet.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnjo tableto.
English: Based on the pharmacological mechanism of action of hydrochlorothiazide its use during the second and third trimesters may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterus, disturbance of electrolyte balance and thrombocytopenia.
Slovenian: Na podlagi farmakološkega mehanizma delovanja hidroklorotiazida obstaja možnost, da ta med drugim in tretjim trimesečjem poslabša fetoplacentno perfuzijo ter pri plodu in novorojenčku povzroči učinke, kot so zlatenica, motnje ravnovesja elektrolitov in trombocitopenija.
English: In a randomised, double-blind, parallel group clinical study including 1975 randomised patients not optimally controlled on 32 mg candesartan cilexetil once daily, the addition of 12.5 mg or 25 mg hydrochlorothiazide resulted in additional blood pressure reductions.
Slovenian: V randomizirani, dvojno slepi klinični študiji vzporednih skupin s 1975 randomiziranimi bolniki, ki niso bili optimalno urejeni z 32 mg cileksetilkandesartanata enkrat na dan, je dodatek 12,5 mg ali 25 mg hidroklorotiazida povzročil dodatno znižanje krvnega tlaka.
English: The corresponding changes in patients with severe renal impairment were approximately 50% and 110%, respectively.
Slovenian: Pri bolnikih s hudo okvaro ledvic je bila sprememba Cmax 50 % in AUC 110 %.
English: The name of your medicine is Atacand Plus.
Slovenian: Vaše zdravilo se imenuje Atacand Plus.
English: No pharmacokinetic interactions of clinical significance were identified in these studies.
Slovenian: V teh študijah niso ugotovili klinično pomembnih farmakokinetičnih medsebojnih delovanj.
English: Loop diuretics are preferred to thiazides in this population.
Slovenian: V tej populaciji imajo diuretiki zanke prednost pred tiazidi.
English: Take special care with Atacand Plus Before you take, or whilst you are taking Atacand Plus, tell your doctor if:
Slovenian: Bodite posebno pozorni pri jemanju zdravila Atacand Plus Preden vzamete zdravilo Atacand Plus in medtem, ko ga jemljete, morate zdravniku povedati: - če imate sladkorno bolezen.
English: Therefore Atacand Plus should not be given to children.
Slovenian: Zato otroci ne smejo dobivati zdravila Atacand Plus.
English: Atacand Plus is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Slovenian: Če ste noseči več kot 3 mesece, pa ga sploh ne smete jemati, ker lahko otroku resno škoduje, če ga jemljete v tem obdobju (glejte poglavje o nosečnosti).
English: The candesartan cilexetil/hydrochlorothiazide combination 32 mg/25 mg was significantly more effective than the 32 mg/12.5 mg combination, and the overall mean blood pressure reductions were 16/10 mmHg and 13/9 mmHg, respectively.
Slovenian: Kombinacija cileksetilkandesartanat/hidroklorotiazid 32 mg/25 mg je bila značilno učinkovitejša od kombinacije 32 mg/12,5 mg; celotno povprečno znižanje krvnega tlaka s prvo je bilo 16/10 mmHg in z drugo 13/9 mmHg.
English: It makes your blood vessels relax and widen.
Slovenian: Deluje tako, da sprosti in razširi žile.
English: AIIRAs should not be initiated during pregnancy.
Slovenian: Med nosečnostjo se ne sme uvesti zdravljenja z ARAII.
English: The terminal t½ of hydrochlorothiazide is approximately 8 hours.
Slovenian: Terminalni razpolovni čas (t1/2) hidroklorotiazida je približno 8 ur.
English: • Some antipsychotics (e.g. thioridazine, chlorpromazine, levomepromazine, trifluoperazine,
Slovenian: • nekaterimi antipsihotiki (kot so npr. tioridazin, klorpromazin, levomepromazin, trifluoperazin,
English: In a double-blind randomised study, Atacand Plus 16 mg/12.5 mg once daily reduced blood pressure significantly more, and controlled significantly more patients, than the combination losartan/hydrochlorothiazide 50 mg/12.5 mg once daily.
Slovenian: V dvojno slepi, randomizirani študiji je zdravilo Atacand Plus 16 mg/12,5 mg enkrat na dan znižalo krvni tlak značilno bolj in je doseglo urejenost stanja pri značilno več bolnikih kot kombinacija losartan/hidroklorotiazid 50 mg/12,5 mg enkrat na dan.
English: The table below presents adverse reactions with candesartan cilexetil from clinical trials and post marketing experience.
Slovenian: Spodnja preglednica navaja neželene učinke cileksetilkandesartanata iz kliničnih preskušanj in obdobja trženja.
English: Atacand Plus may be administered in patients whose blood pressure is not optimally controlled with candesartan cilexetil or hydrochlorothiazide monotherapy or Atacand Plus at lower doses.
Slovenian: Zdravilo Atacand Plus se lahko uporablja pri bolnikih, ki krvnega tlaka nimajo optimalno urejenega z monoterapijo s cileksetilkandesartanatom ali hidroklorotiazidom ali z zdravilom Atacand Plus v manjših odmerkih.
English: As with ACE inhibitors, concomitant use of AIIRAs and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Slovenian: Tako kot zaviralci ACE lahko tudi ARAII, uporabljeni hkrati z nesteroidnimi protivnetnimi zdravili, povečajo tveganje poslabšanja delovanja ledvic (vključno z akutno odpovedjo ledvic) in povečane koncentracije kalija v serumu, zlasti pri bolnikih, ki imajo že sicer slabo delovanje ledvic.
English: Medicines that can be affected by potassium blood levels such as some antipsychotic medicines.
Slovenian: • Zdravila, na katera lahko vpliva koncentracija kalija v krvi, npr. nekatere antipsihotike.
English: Renal impairment/kidney transplantation
Slovenian: Okvara ledvic/presaditev ledvice
English: Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, diclofenac, celecoxib or etoricoxib (medicines to relieve pain and inflammation).
Slovenian: • Nesteroidna protivnetna zdravila, npr. ibuprofen, naproksen, diklofenak, celekoksib ali etorikoksib (zdravila za lajšanje bolečin in ublažitev vnetja).
English: Pharmaco-therapeutic group: Angiotensin II antagonists + diuretics, ATC code: C09DA06
Slovenian: Oznaka ATC: C09DA06
English: When clinically appropriate a direct change from monotherapy to Atacand Plus may be considered.
Slovenian: Če je klinično primerno, je mogoče na zdravilo Atacand Plus preiti neposredno z monoterapije.
English: In controlled clinical studies with candesartan cilexetil/hydrochlorothiazide adverse reactions were mild and transient.
Slovenian: V kontroliranih kliničnih študijah s cileksetilkandesartanatom/hidroklorotiazidom so bili neželeni učinki blagi in prehodni.
English: Hydrochlorothiazide dose-dependently increases urinary potassium excretion which may result in hypokalaemia.
Slovenian: Hidroklorotiazid od odmerka odvisno poveča izločanje kalija v urinu; to lahko povzroči hipokaliemijo.
English: Candesartan is an AIIRA, selective for AT1 receptors, with tight binding to and slow dissociation from the receptor.
Slovenian: Kandesartan je ARAII, selektiven za receptorje AT1.
English: Symptoms such as dizziness, hypotension, thirst, tachycardia, ventricular arrhythmias, sedation/impairment of consciousness and muscle cramps can also be observed.
Slovenian: Pojavijo se lahko tudi simptomi, kot so omotica, hipotenzija, žeja, tahikardija, prekatne motnje srčnega ritma, sedacija/okvara zavesti in mišični krči.
English: Effects on how your kidneys work, especially if you have kidney problems or heart failure.
Slovenian: • Vpliv na delovanje ledvic, zlasti če imate težave z ledvicami ali srčno popuščanje.
English: Hypotension may occur during anaesthesia and surgery in patients treated with AIIRAs due to blockade of the renin-angiotensin system.
Slovenian: Med anestezijo in operacijami se lahko bolnikom, ki prejemajo ARAII, zaradi blokade sistema renin-angiotenzin pojavi hipotenzija.
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately and, if appropriate, alternative therapy should be started.
Slovenian: Zdravljenje z ARAII je treba končati takoj po ugotovitvi nosečnosti in uvesti drugo zdravljenje, če je primerno.
English: There was no statistically significant difference in the primary endpoint, major cardiovascular events (cardiovascular mortality, non-fatal stroke and non-fatal myocardial infarction).
Slovenian: Primarni opazovani dogodek, pomembni kardiovaskularni dogodki (kardiovaskularna umrljivost, možganska kap brez smrtnega izida in miokardni infarkt brez smrtnega izida), se med skupinama ni statistično značilno razlikoval.
English: In two clinical studies (randomised, double-blind, placebo controlled, parallel group) including 275 and 1524 randomised patients, respectively, the candesartan cilexetil/hydrochlorothiazide combinations 32 mg/12.5 mg and 32 mg/25 mg resulted in blood pressure reductions of 22/15 mmHg and 21/14 mmHg, respectively, and were significantly more effective than the respective monocomponents.
Slovenian: V dveh kliničnih študijah (randomiziranih, dvojno slepih, s placebom kontroliranih študijah vzporednih skupin), ki sta zajeli 275 in 1524 randomiziranih bolnikov, je kombinacija cileksetilkandesartanata/hidroklorotiazida 32 mg/12,5 mg dosegla znižanje krvnega tlaka 22/15 mmHg, kombinacija 32 mg/25 mg pa 21/14 mmHg ter sta bili značilno učinkovitejši kot ustrezni sestavini v monoterapiji.
English: The hyperglycaemic effect of beta-blockers and diazoxide may be enhanced by thiazides.
Slovenian: Tiazidi lahko povečajo hiperglikemični učinek zaviralcev beta in diazoksida.
English: There is no clinical experience with Atacand Plus in patients with hepatic impairment.
Slovenian: Kliničnih izkušenj z zdravilom Atacand Plus pri bolnikih z okvaro jeter ni.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS Non-Perforated foil, Perforated Foil
Slovenian: PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU Neperforiran trak, perforiran trak
English: Do not use Atacand Plus after the expiry date which is stated on the carton, blister pack or bottle.
Slovenian: • Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli,
English: Infections and infestations
Slovenian: Anestezija in operacije
English: Dose titration of candesartan cilexetil is recommended in patients at risk for hypotension, such as patients with possible volume depletion (an initial dose of candesartan cilexetil of 4 mg may be considered in these patients).
Slovenian: Odmerek cileksetilkandesartanata je priporočljivo titrirati pri bolnikih s tveganjem hipotenzije, npr. pri bolnikih z možnim intravaskularnim pomankanjem volumna (pri teh bolnikih pride v poštev začetni odmerek 4 mg cileksetilkandesartanata).
English: Thiazide diuretics increase serum uric acid concentration and may precipitate gout in susceptible patients.
Slovenian: Tiazidni diuretiki povečajo koncentracijo sečne kisline v serumu in lahko pri dovzetnih bolnikih sprožijo protin.
English: No additional accumulation of hydrochlorothiazide occurs after repeated doses of the combination compared to monotherapy.
Slovenian: V primerjavi z monoterapijo se po ponavljajočih se odmerkih hidroklorotiazida ne pojavi dodatno kopičenje.