FrancophonIA/ELRC3.0 huggingface dataset:
English: When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29% however, the extent of absorption was not significantly affected (AUC decreased by 11%).
Slovenian: Če sildenafil zaužijemo s hrano, se hitrost absorpcije zmanjša s povprečno zakasnitvijo tmax 60 minut in povprečnim zmanjšanjem Cmax za 29 %, delež absorpcije pa se pomembneje ne zmanjša
English: What Granpidam is and what it is used for What you need to know before you take Granpidam How to take Granpidam
Slovenian: Kaj je zdravilo Granpidam in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Granpidam Kako jemati zdravilo Granpidam Možni neželeni učinki
English: These medicines are often given for relief of chest pain (or “angina pectoris”).
Slovenian: Ta zdravila pogosto uporabljamo za lajšanje bolečine v prsnem košu (angine pektoris).
English: The following serious adverse events were considered to be treatment related, enterocolitis, convulsion, hypersensitivity, stridor, hypoxia, neurosensory deafness and ventricular arrhythmia.
Slovenian: Za naslednje resne neželene učinke menijo, da so povezani z zdravljenjem: enterokolitis, konvulzije, preobčutljivost, stridor, hipoksija, senzorinevralna gluhost in ventrikularna aritmija.
English: Medium dose (n=26)
Slovenian: Srednji odmerek (n = 26)
English: After chronic dosing of 80 mg three times a day to patients with pulmonary arterial hypertension lesser effects in blood pressure reduction were observed (a reduction in both systolic and diastolic pressure of 2 mmHg).
Slovenian: Po kroničnem odmerjanju 80 mg trikrat na dan pri bolnikih s pljučno arterijsko hipertenzijo so opažali manjše učinke na znižanje krvnega tlaka (znižanje sistoličnega in diastoličnega tlaka za 2 mmHg).
English: If you have an erection, which lasts continuously for more than 4 hours, stop taking Granpidam and contact your doctor immediately (see also section 4).
Slovenian: Če imate erekcijo, ki nepretrgano traja dlje kot 4 ure, prenehajte jemati zdravilo Granpidam in nemudoma obvestite zdravnika (glejte tudi poglavje 4).
English: Psychiatric disorders Common insomnia, anxiety
Slovenian: Psihiatrične motnje pogosti nespečnost, anksioznost
English: The 20 mg tablet should not be used in cases where 10 mg TID should be administered in younger patients.
Slovenian: 20 mg tablet se ne sme uporabiti pri odmerjanju 10 mg trikrat na dan pri mlajših bolnikih.
English: - currently have a stomach ulcer, a bleeding disorder (such as haemophilia) or problems with nose bleeds.
Slovenian: - imate trenutno razjedo na želodcu, ste nagnjeni h krvavitvam (npr. imate hemofilijo) ali imate težave s krvavitvami iz nosu.
English: A downward dose adjustment to 20 mg twice daily should be considered when sildenafil is co-administered to patients already receiving CYP3A4 inhibitors like erythromycin or saquinavir.
Slovenian: O zmanjšanju odmerka na 20 mg dvakrat na dan je treba razmisliti pri bolnikih, ki dobijo sildenafil in že prejemajo zaviralce CYP3A4, npr. eritromicin ali sakvinavir.
English: After oral doses of 20 mg three times a day, the mean maximum total plasma concentration of sildenafil at steady state is approximately 113 ng/ml.
Slovenian: Po peroralnih odmerkih 20 mg trikrat na dan je povprečna največja celotna koncentracija sildenafila v plazmi v stanju dinamičnega ravnovesja približno 113 ng/ml.
English: There was no significant difference in effect between sildenafil doses.
Slovenian: Učinek se med odmerki sildenafila ni pomembno razlikoval.
English: Efficacy in terms of improvement of exercise capacity or pulmonary haemodynamics has been shown in primary pulmonary hypertension and pulmonary hypertension associated with congenital heart disease (see section 5.1).
Slovenian: Učinkovitost v smislu izboljšanja zmožnosti prenašanja napora oziroma pljučne hemodinamike se je pokazala pri primarni pljučni hipertenziji in pljučni hipertenziji, povezani s prirojenim obolenjem srca (glejte poglavje 5.1).
English: Sildenafil (100 mg single dose) did not affect the steady state pharmacokinetics of the HIV protease inhibitor saquinavir, which is a CYP3A4 substrate/inhibitor.
Slovenian: Sildenafil (v posamičnem odmerku 100 mg) ni vplival na farmakokinetiko zaviralca proteaze HIV sakvinavirja (ki je substrat/zaviralec CYP3A4) v stanju dinamičnega ravnovesja.
English: The overall frequency of discontinuations in sildenafil/epoprostenol treated patients due to adverse events was 5.2% compared to 10.7% in the placebo/epoprostenol treated patients.
Slovenian: Skupna pogostnost prekinitev zaradi neželenih učinkov je bila med bolniki, ki so dobivali sildenafil/epoprostenol, 5,2 % in pri tistih, ki so dobivali placebo/epoprostenol, 10,7 %.
English: In a study of healthy volunteers sildenafil at steady state (80 mg three times a day) resulted in a 50% increase in bosentan AUC (125 mg twice daily).
Slovenian: V študiji pri zdravih prostovoljcih je sildenafil v stanju dinamičnega ravnovesja (80 mg trikrat na dan) povzročil 50 % povečanje AUC bosentana (125 mg dvakrat na dan).
English: Long-term survival data in naive population
Slovenian: Podatki o dolgoročnem preživetju pri populaciji,ki še ni prejemala zdravljenja
English: Combination with the most potent of the CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir) (see section 4.5).
Slovenian: Kombinacija z najmočnejšimi zaviralci CYP3A4 (npr. ketokonazolom, itrakonazolom, ritonavirjem) (glejte poglavje 4.5).
English: Pack size of 300 tablets in a carton.
Slovenian: Pakiranje s 300 tabletami v škatli.
English: A population pharmacokinetic analysis of sildenafil data from adult PAH patients in clinical trials including a 12 week study to assess the efficacy and safety of oral sildenafil 20 mg three times a day when added to a stable dose of bosentan (62.5 mg-125 mg twice a day) indicated a decrease in sildenafil exposure with bosentan co-administration, similar to that observed in healthy volunteers (see sections 4.4 and 5.1).
Slovenian: Populacijska farmakokinetična analiza podatkov o sildenafilu pri odraslih bolnikih s PAH iz kliničnih preskušanj, vključno z 12-tedensko študijo za oceno učinkovitost in varnost peroralnega sildenafila 20 mg trikrat na dan, kadar so ga dodajali stabilnemu odmerku bosentana (62,5-125 mg dvakrat na dan), je pokazala zmanjšanje izpostavljenosti sildenafilu ob sočasni uporabi z bosentanom, kar je podobno ugotovitvam pri zdravih prostovoljcih (glejte poglavji 4.4 in 5.1).
English: Population pharmacokinetics
Slovenian: Populacijska farmakokinetika
English: The estimated difference between the medium sildenafil dose and placebo was 11.33% (95% CI: 1.72 to 20.94) (see Table 2).
Slovenian: Ocenjena razlika med povprečnim odmerkom sildenafila in placebom je znašala 11,33 % (95 % IZ: 1,72 do 20,94) (glejte Preglednico
English: Most of these adverse reactions were considered mild to moderate in severity.
Slovenian: Resnost večine teh neželenih učinkov je bila blaga do zmerna.
English: Prolonged and sometimes painful erections have been reported in men after taking sildenafil (frequency not known).
Slovenian: Pri moških, ki so jemali sildenafil, so poročali o podaljšani in včasih boleči erekciji (pogostnost ni znana).
English: In pulmonary arterial hypertension patients, the oral bioavailability of sildenafil after 80 mg three times a day was on average 43% (90% CI: 27%-60%) higher compared to the lower doses.
Slovenian: Pri bolnikih s pljučno arterijsko hipertenzijo je bila peroralna biološka uporabnost sildenafila ob 80 mg trikrat na dan v povprečju za 43 % (90 % IZ: od 27 do 60 %) večja kot ob manjših odmerkih.
English: There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration.
Slovenian: Podatkov o varnosti uporabe sildenafila pri bolnikih z motnjami strjevanja krvi ali z aktivno peptično razjedo ni.
English: Wessling Hungary Kft Fòti ùt 56., Budapest 1047, Hungary or
Slovenian: Fòti ùt 56., Budapest 1047,
English: This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug.
Slovenian: Selektivnost tega presnovka za fosfodiesteraze je podobna selektivnosti sildenafila, njegov vpliv na PDE5 pa in vitro pomeni približno 50 % vpliva matičnega zdravila.
English: Doses up to 80 mg three times a day (4 times the recommended dose of 20 mg three times a day) were administered and after 3 years 87% of 183 patients on study treatment were receiving sildenafil 80 mg TID.
Slovenian: Proučevali so odmerke do 80 mg trikrat na dan (4-kratni priporočeni odmerek 20 mg trikrat na dan) in po 3 letih je 87 % od 183 bolnikov v študiji prejemalo sildenafil v odmerku 80 mg trikrat na dan.
English: White to off white, round shaped, approximately 6.6 mm in diameter, biconvex, film-coated tablets, debossed with ‘20' on one side and plain on other side.
Slovenian: Bele do sivkasto bele, okrogle, s premerom približno 6,6 mm, bikonveksne, filmsko obložene tablete, z vtisnjenim znakom »20« na eni strani in brez znakov na drugi strani.
English: Sildenafil has no effect on visual acuity or contrast sensitivity.
Slovenian: Sildenafil ne vpliva na ostrino vida ali razločevanje kontrasta.
English: Pack size of 90 tablets in a carton.
Slovenian: Pakiranje z 90 tabletami v škatli.
English: Patients who previously failed bosentan therapy were excluded from the study.
Slovenian: Študija ni vključila bolnikov, pri katerih je bilo pred tem neuspešno zdravljenje z bosentanom.
English: Differences in 6MWD were observed between patients with primary PAH and PAH associated with connective tissue disease.
Slovenian: Razlike v 6MWD pa so opazili pri bolnikih s primarno PAH in z boleznimi vezivnega tkiva povezano PAH.
English: In patients with pulmonary arterial hypertension, the average steady state concentrations were 20-50% higher over the investigated dose range of 20-80 mg three times a day compared to healthy volunteers.
Slovenian: Pri bolnikih s pljučno arterijsko hipertenzijo je bila povprečna koncentracija v stanju dinamičnega ravnovesja v proučevanem območju od 20 do 80 mg trikrat na dan od 20 do 50 % večja kot pri zdravih prostovoljcih.
English: Newly reported adverse reactions, which occurred more frequently in the sildenafil/ epoprostenol group, were ocular hyperaemia, vision blurred, nasal congestion, night sweats, back pain and dry mouth.
Slovenian: Novo opisani neželeni učinki, pogostejši v skupini, ki je dobivala sildenafil/epoprostenol, so bili očesna hiperemija, zamegljen vid, zamašenost nosu, nočno znojenje, bolečine v hrbtu in suha usta.
English: Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil.
Slovenian: Sok grenivke šibko zavira presnovo s CYP3A4 v črevesni steni in lahko nekoliko poveča koncentracijo sildenafila v plazmi.
English: Of the 94 subjects reporting a serious adverse event, 14/55 (25.5%) subjects were in the low dose group, 35/74 (47.3%) in the medium dose group, and 45/100 (45%) in the high dose group.
Slovenian: Od 94 preiskovancev, pri katerih so poročali o resnem neželenem učinku, je bilo 14/55 (25,5 %) preiskovancev iz skupine z majhnim odmerkom, 35/74 (47,3 %) iz skupine s srednjim odmerkom in 45/100 (45 %) iz skupine z velikim odmerkom.
English: Sage House, 319 Pinner Road, North Harrow, Middlesex HA1 4HF, United Kingdom or
Slovenian: North Harrow, Middlesex HA1 4HF,
English: In order to minimise the potential for developing postural hypotension, patients should be haemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment.
Slovenian: Da bo možnost za posturalno hipotenzijo čim manjša, morajo biti bolniki, zdravljeni z antagonistom alfa, pred uvedbo sildenafila hemodinamsko stabilni.
English: Kaplan-Meier estimates of survival at 3 years in patients >20 kg in weight at baseline were 94%, 93% and 85% in the low, medium and high dose groups, respectively; for patients ≤20 kg in weight at baseline, the survival estimates were 94% and 93% for subjects in the medium and high dose groups respectively (see sections 4.4 and 4.8).
Slovenian: Kaplan-Meierjeva ocena preživetja po 3 letih pri bolnikih, pri katerih je telesna masa na začetku znašala > 20 kg, je bila ocenjena kot 94 %, 93 % in 85 % pri preiskovancih v skupinah z majhnim, srednjim oziroma velikim odmerkom; pri bolnikih, pri katerih je telesna masa na začetku znašala ≤ 20 kg, je bila ocena preživetja 94 % in 93 % pri preiskovancih v skupinah s srednjim oziroma velikim odmerkom (glejte poglavji 4.4 in 4.8).
English: Due to lack of data, Granpidam should not be used in pregnant women unless strictly necessary.
Slovenian: Zaradi pomanjkanja podatkov zdravila Granpidam pri nosečnicah ne smete uporabljati, če to ni nujno potrebno.
English: How to take Granpidam
Slovenian: Kako jemati zdravilo Granpidam
English: Patients were randomised to placebo or sildenafil (in a fixed titration starting from 20 mg, to 40 mg and then 80 mg, three times a day as tolerated) when used in combination with intravenous epoprostenol.
Slovenian: Bolnike so randomizirali na placebo ali sildenafil (v fiksni titraciji najprej 20 mg, nato 40 mg in 80 mg trikrat na dan, kot so ga prenašali), uporabljen v kombinaciji z intravenskim epoprostenolom.
English: Co-administration of oral contraceptives (ethinyloestradiol 30 µg and levonorgestrel 150 µg) did not affect the pharmacokinetics of sildenafil.
Slovenian: Sočasna uporaba peroralnih kontraceptivov (30 μg etinilestradiola in 150 μg levonorgestrela) ni vplivala na farmakokinetiko sildenafila.
English: Cimetidine (800 mg), a cytochrome P450 inhibitor and a non-specific CYP3A4 inhibitor, caused a 56% increase in plasma sildenafil concentrations when co-administered with sildenafil (50 mg) to healthy volunteers.
Slovenian: Cimetidin (800 mg), zaviralec citokroma P450 in nespecifičen zaviralec CYP3A4, je ob sočasni uporabi s sildenafilom (50 mg) pri zdravih prostovoljcih povzročil 56 % povečanje koncentracije sildenafila v plazmi.
English: Consequently, should signs of pulmonary oedema occur when sildenafil is administered in patients with pulmonary hypertension, the possibility of associated veno-occlusive disease should be considered.
Slovenian: Če se med uporabo sildenafila pri bolnikih s pljučno hipertenzijo pojavijo znaki pljučnega edema, je zato treba razmisliti o možnosti spremljajoče venookluzivne bolezni.
English: Doses up to 80 mg TID were administered and after 3 years 68% of 133 patients on study treatment were receiving sildenafil 80 mg TID.
Slovenian: Prejemali so odmerke do 80 mg trikrat na dan in po 3 letih je 68 % od 133 bolnikov v študiji prejemalo sildenafil v odmerku 80 mg trikrat na dan.
English: Subjects who had been in the placebo group in the short-term study were randomly reassigned to sildenafil treatment; subjects weighing ≤20 kg entered the medium or high dose groups (1:1), while subjects weighing >20 kg entered the low, medium or high dose groups (1:1:1).
Slovenian: Preiskovanci, ki so v kratkoročni študiji prejemali placebo, so bili randomizirani v skupine, ki so se zdravile s sildenafilom: preiskovanci s telesno maso ≤ 20 kg so nadaljevali v skupinah s srednjim ali velikim odmerkom (1 : 1), preiskovanci s telesno maso > 20 kg pa v skupinah z majhnim, srednjim ali velikim odmerkom (1 : 1 : 1).
English: If you experience sudden decrease or loss of vision, stop taking Granpidam and contact your doctor immediately (see also section 4).
Slovenian: Če doživite nenadno poslabšanje ali izgubo vida, prenehajte jemati zdravilo Granpidam in nemudoma obvestite zdravnika (glejte tudi poglavje 4).
English: Population pharmacokinetic analysis of pulmonary arterial hypertension clinical trial data indicated a reduction in sildenafil clearance and/or an increase of oral bioavailability when co-administered with CYP3A4 substrates and the combination of CYP3A4 substrates and beta-blockers.
Slovenian: Populacijska farmakokinetična analiza podatkov iz kliničnih preskušanj pri pljučni arterijski hipertenziji je pokazala, da se očistek sildenafila zmanjša in/ali se njegova peroralna biološka uporabnost poveča, če je uporabljen sočasno s substrati CYP3A4 ali kombinacijo substratov CYP3A4 in antagonistov beta.
English: The primary endpoint was the placebo-corrected percentage change in peak VO2 from baseline to week 16 assessed by CPET testing in the combined dose groups (Table 2).
Slovenian: Glavni opazovani dogodek je bil s placebom korigiran odstotek spremembe pri največji vrednosti VO2 glede na izhodiščno vrednost do 16. tedna, kar so ocenjevali s CPET pri skupinah z vsemi odmerki (Preglednica 2).
English: At single doses of 200 mg the incidence of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, and altered vision) was increased.
Slovenian: Uporabo posamičnih odmerkov 200 mg je spremljala večja incidenca neželenih reakcij (glavobola, zardevanja, omotice, dispepsije, zamašenega nosu in sprememb vida).
English: If you stop taking Granpidam
Slovenian: Če ste prenehali jemati zdravilo Granpidam
English: The most potent of the CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have effects similar to ritonavir (see section 4.3).
Slovenian: Pri najmočnejših zaviralcih CYP3A4, npr. pri ketokonazolu in itrakonazolu, bi lahko pričakovali učinke, podobne učinkom ritonavirja (glejte poglavje 4.3).
English: Side effects reported commonly (may affect up to 1 in 10 people) included: infection under the skin, flu-like symptoms, inflammation of the sinuses, reduced number of red blood cells (anaemia), fluid retention, difficulty sleeping, anxiety, migraine, shaking, “pins and needles”-like sensation, burning sensation, reduced sense of touch, bleeding at the back of the eye, effects on vision, blurred vision and light sensitivity, effects on colour vision, eye irritation, bloodshot eyes /red eyes, vertigo, bronchitis, nosebleed, runny nose, cough, stuffy nose, stomach inflammation, gastroenteritis, heartburn, piles, abdominal distension, dry mouth, hair loss, redness of the skin, night sweats, muscle aches, back pain and increased body temperature.
Slovenian: Pogosto opisani neželeni učinki (pojavijo se lahko pri največ 1 od 10 bolnikov) so vnetje podkožja, gripi podobni simptomi, vnetje sinusov, znižano število rdečih krvnih celic (anemija), zadrževanje tekočine, težave s spanjem, tesnobnost, migrena, tresenje, »mravljinčenju« podoben občutek, pekoč občutek, zmanjšana občutljivost na dotik, krvavenje v ozadju očesa, učinki na vid, zamegljen vid in občutljivost na svetlobo, vpliv na barvni vid, draženje oči, pordelost oči, vrtoglavica, bronhitis, krvavitev iz nosu, izcedek iz nosu, kašelj, zamašen nos, vnetje želodca, gastroenteritis, zgaga, hemoroidi, napenjanje v trebuhu, suha usta, izguba las in dlak, pordelost kože, nočno znojenje, bolečine v mišicah, bolečine v hrbtu in zvišanje telesne temperature.
English: Infections and infestations Common cellulitis, influenza, bronchitis, sinusitis, rhinitis, gastroenteritis
Slovenian: Neželeni učinek pogosti flegmona, gripa, bronhitis, sinuzitis, rinitis, gastroenteritis
English: Sildenafil is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5), the enzyme that is responsible for degradation of cGMP.
Slovenian: Sildenafil je močan in selektiven zaviralec za ciklični gvanozinmonofosfat (cGMP) specifične fosfodiesteraze tipa 5 (PDE5).
English: Sildenafil exposure was 5-fold higher at a dose of 80 mg three times a day compared to the exposure at a dose of 20 mg three times a day.
Slovenian: Izpostavljenost sildenafilu je bila ob odmerku 80 mg trikrat na dan 5- krat večja kot ob odmerku 20 mg trikrat na dan.
English: Concomitant use of riociguat with PDE5 inhibitors, including sildenafil, is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba riociguata z zaviralci PDE5, vključno s sildenafilom, je kontraindicirana (glejte poglavje 4.3).
English: The most commonly reported adverse reactions that occurred (greater or equal to 10%) on sildenafil compared to placebo were headache, flushing, dyspepsia, diarrhoea and pain in extremity.
Slovenian: Najpogosteje opisani neželeni učinki, ki so se pojavili (več ali enako 10 %) med uporabo sildenafila v primerjavi s placebom, so bili glavobol, zardevanje, dispepsija, driska in bolečine v okončinah.
English: Granpidam with food and drink You should not drink grapefruit juice while you are being treated with Granpidam.
Slovenian: Med zdravljenjem z zdravilom Granpidam ne smete piti grenivkinega soka.
English: When prescribing sildenafil, physicians should carefully consider whether patients with certain underlying conditions could be adversely affected by sildenafil's mild to moderate vasodilatory effects, for example patients with hypotension, patients with fluid depletion, severe left ventricular outflow obstruction or autonomic dysfunction (see section 4.4).
Slovenian: Preden zdravnik predpiše sildenafil, mora natančno razmisliti, ali bi blagi do zmerni vazodilatacijski učinki sildenafila lahko imeli neželene posledice za bolnike z določenimi že obstoječimi boleznimi, npr. hipotenzijo, pomanjkanjem tekočine, hudo obstrukcijo iztočnega dela levega prekata ali motnjami avtonomnega uravnavanja krvnega tlaka (glejte poglavje 4.4).
English: Therefore dose adjustments are recommended when using CYP3A4 inhibitors (see section 4.2).
Slovenian: Zato je med uporabo zaviralcev CYP3A4 priporočljivo prilagoditi odmerek (glejte poglavje 4.2).
English: The most common adverse reactions that occurred (with a frequency ≥1%) in sildenafil patients (combined doses) and with a frequency >1% over placebo patients were pyrexia, upper respiratory tract infection (each 11.5%), vomiting (10.9%), erection increased (including spontaneous penile erections in male subjects) (9.0%), nausea, bronchitis (each 4.6%), pharyngitis (4.0%), rhinorrhoea (3.4%), and pneumonia, rhinitis (each 2.9%).
Slovenian: Najpogostejši neželeni učinki, ki so se pojavljali (s pogostnostjo ≥1 %) pri bolnikih, zdravljenih s sildenafilom (vsi odmerki), in pri katerih je bila pogostnost pojavljanja > 1 % večja kot pri placebu, so bili pireksija, okužba zgornjega dela dihal (oba 11,5 %), bruhanje (10,9 %), močnejša erekcija (vključno s spontanimi erekcijami penisa pri bolnikih) (9,0 %), navzea, bronhitis (vsak 4,6 %), faringitis (4,0 %), rinoreja (3,4 %) in pljučnica ter rinitis (vsak
English: The safety and efficacy of sildenafil when co-administered with other PDE5 inhibitor products, including the combined use of sildenafil for erectile dysfunction, has not been studied in PAH patients and such concomitant use is not recommended (see section 4.5).
Slovenian: Varnosti in učinkovitosti sildenafila, uporabljenega hkrati z drugimi zaviralci PDE5, vključno s kombinirano uporabo sildenafila za erektilno disfunkcijo, pri bolnikih s PAH niso raziskali, zato sočasna uporaba ni priporočljiva (glejte poglavje 4.5).
English: Granpidam brings down blood pressure in the lungs by widening the blood vessels in the lungs.
Slovenian: Zdravilo Granpidam širi žile v pljučih in s tem zniža krvni tlak v pljučih.
English: A downward dose adjustment to 20 mg once daily is recommended in case of co-administration with more potent CYP3A4 inhibitors clarithromycin, telithromycin and nefazodone.
Slovenian: Zmanjšanje odmerka na 20 mg enkrat na dan je priporočljivo v primeru sočasne uporabe z močnejšimi zaviralci CYP3A4, npr. s klaritromicinom, telitromicinom in nefazodonom.
English: No significant interactions were shown when sildenafil (50 mg) was co-administered with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolised by CYP2C9.
Slovenian: Med sočasno uporabo sildenafila (50 mg) in tolbutamida (250 mg) ali varfarina (40 mg), ki se presnavljata s CYP2C9, ni bilo pomembnih interakcij.
English: A mean placebo-corrected treatment effect of -3.9 mmHg was observed in favour of sildenafil (95% CI: -5.7, -2.1) (p = 0.00003).
Slovenian: Ugotovljeni povprečni za placebo korigirani učinek zdravljenja je bil -3,9 mmHg v korist sildenafila (95 % IZ: -5,7, -2,1) (p = 0,00003).