FrancophonIA/ELRC3.0 huggingface dataset:
English: In clinical studies, > 90% of patients responded at these doses, achieving a reversal of neutropenia in a median of 2 days.
Slovenian: V kliničnih študijah se je > 90 % bolnikov odzvalo na te odmerke in za odpravo nevtropenije so v povprečju potrebovali 2 dni.
English: In assessing the number of progenitor cells harvested in patients treated with filgrastim, particular attention should be paid to the method of quantitation.
Slovenian: Pri ocenjevanju števila matičnih celic, dobljenih pri bolnikih, ki prejemajo filgrastim, je treba posebno pozornost nameniti načinu kvantifikacije.
English: Grastofil dosing should be maintained until the last leukapheresis.
Slovenian: Z dajanjem Grastofila je treba nadaljevati do zadnje levkafereze.
English: • transfusion reaction
Slovenian: • reakcije na transfuzijo
English: cells/kg is based on published experience resulting in adequate haematologic reconstitution.
Slovenian: celic/kg temelji na objavljenih podatkih, po katerih je to število zadostovalo za hematološko obnovo.
English: It is recommended to perform morphologic and cytogenetic bone marrow examinations in patients at regular intervals (approximately every 12 months).
Slovenian: Priporočljivo je izvajati morfološke in citogenetske preiskave kostnega mozga v rednih časovnih presledkih (približno na vsakih 12 mesecev).
English: The safety and efficacy of filgrastim administration in de novo AML patients aged < 55 years with good cytogenetics [t(8; 21), t(15; 17), and inv(16)] have not been established.
Slovenian: Varnost in učinkovitost uporabe filgrastima pri bolnikih z na novo nastalo akutno mieloično levkemijo, ki so mlajši od 55 let in imajo dobro citogenetiko [t(8; 21), t(15; 17) in inv (16)], nista bili dokazani.
English: As with other haematopoietic growth factors, G-CSF has shown in vitro stimulating properties on human endothelial cells.
Slovenian: Tako kot drugi hematopoetski rastni faktorji je tudi G-CSF in vitro izkazal spodbujevalen učinek na človeške endotelijske celice.
English: ANC should be monitored closely, especially during the first few weeks of filgrastim therapy.
Slovenian: ANC je treba skrbno spremljati, zlasti v obdobju prvih nekaj tednov zdravljenja s filgrastimom.
English: There is a positive linear correlation between the dose and the serum concentration of filgrastim, whether administered intravenously or subcutaneously.
Slovenian: Obstaja pozitivna linearna korelacija med odmerkom in koncentracijo filgrastima v serumu, bodisi po intravenski ali subkutani uporabi.
English: The usual dose of Grastofil varies depending on your illness and weight.
Slovenian: Običajni odmerek zdravila Grastofil je odvisen od vaše bolezni in telesne mase.
English: Some cases of splenic rupture were fatal (see section 4.4).
Slovenian: Nekateri primeri raztrganja vranice so bili usodni (glejte poglavje 4.4.
English: • disease which causes bones to become less dense, making them weaker, more brittle and likely to break (osteoporosis)
Slovenian: • bolezen, zaradi katere se manjša gostota kosti, ki zato postajajo šibke, krhkejše in bolj nagnjene k zlomom (osteoporoza)
English: Your doctor may want to monitor you closely, see section 4 of the package leaflet.
Slovenian: Zdravnik vas bo morda bolj natančno spremljal, glejte poglavje 4 navodila za uporabo.
English: If you are a patient with severe chronic neutropenia, you may be at risk of developing cancer of the blood (leukaemia, myelodysplastic syndrome (MDS)).
Slovenian: Če ste bolnik s hudo kronično nevtropenijo, obstaja morda tveganje za razvoj krvnega raka (levkemija, mielodisplastični sindrom (MDS)).
English: Accidental one-time exposure to freezing temperatures does not adversely affect the stability of Grastofil.
Slovenian: Nenamerna enkratna izpostavljenost zamrzovalnim temperaturam, nima vpliva na stabilnost zdravila Grastofil.
English: • decreased feeling of sensitivity, especially in the skin (hypoaesthesia)
Slovenian: • zmanjšan občutek za čutenje, zlasti na koži (hipestezija)
English: Haematuria was common and proteinuria occurred in a small number of patients.
Slovenian: Pogosta je bila hematurija in pri majhnem številu bolnikov se je pojavila proteinurija.
English: In other circumstances, additional leukaphereses are recommended.
Slovenian: V drugih okoliščinah so priporočljive dodatne levkafereze.
English: The safety and efficacy of filgrastim given on the same day as myelosuppressive cytotoxic chemotherapy have not been definitively established.
Slovenian: Varnost in učinkovitost filgrastima, uporabljenega na isti dan, kot je bila uporabljena mielosupresivna citotoksična kemoterapija, nista bili dokončno potrjeni.
English: This medicinal product contains 50 mg sorbitol.
Slovenian: To zdravilo vsebuje 50 mg sorbitola.
English: Any Grastofil syringes that have been out of the refrigerator for longer than 15 days should not be used and should be disposed of in accordance with local requirements.
Slovenian: Brizg zdravila Grastofil, ki so zunaj hladilnika dlje kot 15 dni, ne smete uporabiti in jih morate zavreči v skladu z lokalnimi predpisi.
English: Subsequently, the dose may be individually adjusted every 1-2 weeks to maintain the average neutrophil count between 1.5 x 10
Slovenian: Nato je mogoče odmerek individualno prilagajati na vsak(a) 1-2 tedna, da se ohrani povprečno število nevtrofilcev med 1,5 x 10
English: At the end of this period, Grastofil should not be put back in the refrigerator and should be disposed of in accordance with local requirements.
Slovenian: Po tem obdobju se zdravila Grastofil ne sme shraniti nazaj v hladilnik in ga je treba zavreči v skladu z lokalnimi predpisi.
English: If you forget to use Grastofil
Slovenian: Če ste pozabili uporabiti zdravilo Grastofil
English: Grastofil is injected into the tissue just under the skin.
Slovenian: Grastofil se vbrizga v tkivo tik pod kožo.
English: The efficacy of treatment was clear for this age group, which included most patients with congenital neutropenia.
Slovenian: Učinkovitost zdravljenja v tej starostni skupini, ki je vključevala večinoma bolnike s prirojeno nevtropenijo, je bila očitna.
English: Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used.
Slovenian: Po indukcijskem in konsolidacijskem zdravljenju akutne mieloične levkemije je trajanje zdravljenja lahko znatno daljše (tudi do 38 dni), odvisno od vrste, odmerka in sheme odmerjanja citotoksične kemoterapije.
English: When peripheral blood progenitor cell transplantation is envisaged it is advisable to plan the stem cell mobilisation procedure early in the treatment course of the patient.
Slovenian: Če je predvidena presaditev krvotvornih matičnih celic iz periferne krvi, je postopek izplavljanja matičnih celic priporočljivo načrtovati v zgodnjem obdobju bolnikovega zdravljenja.
English: There is insufficient data to evaluate filgrastim use in elderly subjects for other approved Grastofil indications.
Slovenian: Za ovrednotenje uporabe filgrastima pri starejših osebah pri drugih odobrenih indikacijah ni dovolj podatkov.
English: Once Grastofil has been out at room temperature it should not be put back into the refrigerator.
Slovenian: Ko je zdravilo Grastofil shranjeno pri sobni temperaturi, ga ne smete več dati nazaj v hladilnik.
English: It is unknown whether filgrastim / metabolites are excreted in human milk.
Slovenian: Ni znano, ali se filgrastim/presnovki izločajo v materino mleko.
English: Neutropenia may be a long-standing condition where your body does not make enough neutrophils, or it may be caused by drugs used to treat cancer.
Slovenian: Nevtropenija je lahko dolgotrajna bolezen, pri kateri telo ne tvori dovolj nevtrofilcev, lahko pa jo povzročijo tudi zdravila za zdravljenje raka.
English: Following subcutaneous administration of recommended doses, serum concentrations were maintained above 10 ng/mL for 8 - 16 hours.
Slovenian: Po subkutanem dajanju priporočenega odmerka se je serumska koncentracija vzdrževala nad vrednostjo 10 ng/ml 8 do 16 ur.
English: Nevertheless, a risk of promotion of a malignant myeloid clone cannot be excluded.
Slovenian: Tveganja za napredovanje mieloidnega rakastega klona ne moremo izključiti.
English: The solution should be visually inspected prior to use.
Slovenian: Raztopino morate pred uporabo vizualno pregledati.
English: If you notice a spot of blood you may gently dab it away with a cotton ball or tissue.
Slovenian: Če opazite kapljico krvi, jo nežno obrišite z bombažno vato ali robčkom.
English: It can also be given as a daily slow injection into the vein (known as an intravenous infusion).
Slovenian: Daje se lahko tudi s počasnim injiciranjem v veno (znano kot intravensko infundiranje).
English: For patients treated with filgrastim diluted to concentrations below 1.5 MU (15 µg) per mL, human serum albumin (HSA) should be added to a final concentration of 2 mg/mL.
Slovenian: Pri bolnikih, ki se zdravijo s filgrastimom, razredčenim na koncentracije pod 1,5 M e. (15 mikrogramov) na mililiter, je treba dodati humani serumski albumin (HSA) do končne koncentracije 2 mg/ml.
English: Grastofil is usually given as a daily injection into the tissue just under the skin (known as a subcutaneous injection).
Slovenian: Zdravilo Grastofil se običajno daje vsakodnevno z injekcijo v tkivo tik pod kožo (znano kot subkutana injekcija).
English: Filgrastim is a recombinant methionyl human granulocyte-colony stimulating factor produced in Escherichia coli (BL21) by recombinant DNA technology.
Slovenian: Filgrastim je rekombinantni metionilirani humani granulocitne kolonije spodbujajoči faktor pridobljen v Escherichia coli (BL21) s pomočjo rekombinantne DNA tehnologije.
English: Chemical and physical in-use stability of the diluted solution for infusion has been demonstrated for 24 hours at 2 °C to 8 °C.
Slovenian: Kemična in fizikalna stabilnost razredčene raztopine za infundiranje med uporabo sta bili dokazani za obdobje 24 ur pri temperaturi od 2 °C do 8 °C.
English: Urinalysis monitoring is recommended.
Slovenian: Priporoča se spremljanje z analizo urina.
English: What Grastofil is and what it is used for
Slovenian: Kaj je zdravilo Grastofil in za kaj ga uporabljamo
English: Donors who receive G-CSFs for PBPC mobilisation should be monitored until haematological indices return to normal.
Slovenian: Darovalce, ki za izplavljanje PBPC dobivajo G-CSF, je treba spremljati, dokler se jim hematološke vrednosti ne normalizirajo.
English: If you experience a loss of response or failure to maintain a response with filgrastim treatment, your doctor will investigate the reasons why including whether you have developed antibodies which neutralise filgrastim's activity.
Slovenian: Če se pojavi izguba odziva ali neuspeh pri vzdrževanju odziva na zdravljenje s filgrastimom, bo zdravnik preučil razloge za to, vključno s tem, ali so se pri vas razvila protitelesa, ki nevtralizirajo aktivnost filgrastima.
English: Grastofil is available in packs containing 1 and 5 pre-filled syringes.
Slovenian: Zdravilo Grastofil je na voljo v pakiranjih, ki vsebujejo 1 in 5 napolnjenih injekcijskih brizg.
English: World Trade Center Moll de Barcelona s/n, Edifici Est 6ª planta 08039 Barcelona Spain
Slovenian: World Trade Center, Moll de Barcelona, s/n, Edifici Est 6ª planta,
English: Call your doctor right away if you experience puffiness in your face or ankles, blood in your urine or brown-coloured urine or you notice you urinate less than usual.
Slovenian: Zdravnika takoj pokličite, če se vam pojavi otekanje obraza ali gležnjev, kri v urinu ali rjavo obarvan urin ali če opazite, da urinirate manj kot običajno.
English: In pregnant rats, no maternal or fetal toxicity was observed at doses up to 575 μg/kg/day.
Slovenian: Pri brejih podganah niso opazili nobene toksičnosti za samice ali plod pri odmerkih do 575 mikrogramov/kg/dan.
English: EG LABO-Laboratoires Eurogenerics SAS Telephone +33/1-46.94.86.86
Slovenian: EG LABO-Laboratoires Eurogenerics SAS Tél:+33/1-46.94.86.86
English: Filgrastim stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection.
Slovenian: Filgrastim spodbuja kostni mozeg (tkivo, kjer nastajajo nove krvne celice), da proizvaja več belih krvnih celic, ki telesu pomagajo v boju z okužbami.
English: • you are being treated for severe chronic neutropenia and you have blood in your urine (haematuria).
Slovenian: • se zdravite zaradi hude kronične nevtropenije in imate kri v urinu (hematurija).
English: The safety and efficacy of filgrastim has not been assessed in normal donors less than 16 years or greater than 60 years of age.
Slovenian: Varnost in učinkovitost filgrastima pri zdravih darovalcih, mlajših od 16 ali starejših od 60 let, nista bili ocenjeni.
English: These could be symptoms of a condition called “sepsis” (also called "blood poisoning"), a severe infection with whole-body inflammatory response which can be life threatening and needs urgent medical attention.
Slovenian: To so lahko simptomi stanja, imenovanega "sepsa" (tudi "zastrupitev krvi"), resne okužbe z vnetnim odzivom celega telesa, ki je lahko smrtno nevarna in jo je treba urgentno zdraviti.
English: Grastofil is a white blood cell growth factor (granulocyte colony stimulating factor) and belongs to a group of medicines called cytokines.
Slovenian: Zdravilo Grastofil je rastni faktor belih krvnih celic (granulocitne kolonije spodbujajoči faktor) in sodi v skupino zdravil, imenovanih citokini.
English: Other medicines and Grastofil
Slovenian: Druga zdravila in zdravilo Grastofil
English: In view of the possible risk of microbial contamination, Grastofil pre-filled syringes are for single use only.
Slovenian: Zaradi morebitnega tveganja za mikrobiološko kontaminacijo so napolnjene brizge zdravila Grastofil namenjene samo za enkratno uporabo.
English: N Acute grade II - IV GvHD
Slovenian: N GvHD akutne stopnje II-IV
English: If exposure has been greater than 24 hours or frozen more than once then Grastofil should not be used.
Slovenian: Če je zdravilo Grastofil zamrznjeno več kot 24 ur ali če je zamrznjeno večkrat, ga ne uporabite.
English: Other special precautions Causes of transient neutropenia such as viral infections should be excluded.
Slovenian: Drugi posebni previdnostni ukrepi Izključiti je treba vzroke prehodne nevtropenije, npr. virusne okužbe.
English: Patients who have undergone very extensive prior myelosuppressive therapy may not show sufficient mobilisation of PBPC to achieve the recommended minimum yield (2.0 x 10
Slovenian: Predhodna izpostavljenost citotoksičnim zdravilom Pri bolnikih, ki so prejemali zelo obsežno predhodno mielosupresivno zdravljenje, se lahko zgodi, da izplavljanje PBPC ne zadošča za doseganje priporočenega najmanjšega deleža celic (2,0 x 10
English: Among these, two cases of platelets < 50 x 10
Slovenian: Med temi so v dveh primerih poročali o številu trombocitov < 50 x 10
English: Particular attention should be paid to the number of progenitors mobilised in such patients before the administration of high-dose chemotherapy.
Slovenian: Posebno pozornost je treba nameniti številu matičnih celic, izplavljenih pri takšnih bolnikih pred zdravljenjem s kemoterapijo v velikih odmerkih.
English: What you need to know before you use Grastofil
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Grastofil
English: 9/L during the treatment period, the dose of Grastofil should be reescalated according to the above steps ANC = absolute neutrophil count
Slovenian: 9/l, je treba odmerek Grastofila ponovno povečevati v skladu z zgoraj navedenimi koraki ANC = absolutno število nevtrofilcev (ANC - absolute neutrophil count)
English: In patients, children or adults with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 x 10
Slovenian: Pri otrocih in odraslih bolnikih s hudo prirojeno, ciklično ali idiopatsko nevtropenijo z absolutnim številom nevtrofilcev (ANC - Absolute Neutrophil Count) ≤ 0,5 x 10
English: Do not use Grastofil
Slovenian: Ne uporabljajte zdravila Grastofil
English: Regular urinalysis should be performed to monitor this event.
Slovenian: Za spremljanje tega pojava je treba redno izvajati preiskave urina.
English: In patients with HIV infection
Slovenian: Pri bolnikih, okuženih s HIV
English: Effects of filgrastim on prenatal development have been studied in rats and rabbits.
Slovenian: Učinke filgrastima na razvoj ploda so preučevali pri podganah in kuncih.
English: The incidence of fever and documented infections were not reduced in either setting.
Slovenian: Pogostnost pojavljanja zvišane telesne temperature in dokumentiranih okužb se v nobenem od teh primerov ni zmanjšala.
English: The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed.
Slovenian: Postopek izplavljanja in afereze bi moral potekati v sodelovanju z onkološkohematološkim centrom, ki ima ustrezne izkušnje na tem področju in v katerem lahko na ustrezen način spremljajo krvotvorne matične celice.
English: The dosing in children and adolescents receiving chemotherapy is the same as for adults.
Slovenian: Odmerjanje pri otrocih in mladostnikih, ki prejemajo kemoterapijo, je enako kot pri odraslih.
English: However, the administration of melphalan, carboplatin or carmustine (BCNU) together with filgrastim has been shown to be effective for progenitor mobilisation.
Slovenian: Vendar se je izkazalo, da dajanje melfalana, karboplatina ali karmustina (BCNU) skupaj s filgrastimom ugodno učinkuje na izplavljanje matičnih celic.
English: Other blood cell changes occur, including anaemia and transient increases in myeloid progenitors, which require close monitoring of cell counts.
Slovenian: Pojavijo se še druge spremembe, vključno z anemijo in prehodnimi povečanji števila mieloičnih matičnih celic, zato je treba število celic natančno spremljati.
English: There is insufficient data to further evaluate filgrastim use in paediatric subjects.
Slovenian: Ni dovolj podatkov za dodatno ovrednotenje uporabe filgrastima pri pediatričnih osebah.
English: When diluted in 5% glucose, Grastofil is compatible with glass and a variety of plastics including PVC, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Slovenian: Če je razredčeno s 5-odstotno raztopino glukoze, je zdravilo Grastofil kompatibilno s steklom in različnimi plastičnimi materiali, vključno s PVC, poliolefinom (kopolimerom polipropilena in polietilena) in polipropilenom.
English: The serum elimination half-life of filgrastim is approximately 3.5 hours, with a clearance rate of approximately 0.6 mL/min/kg.
Slovenian: Razpolovni čas izločanja filgrastima iz seruma je približno 3,5 ure; očistek znaša približno 0,6 ml/min/kg.
English: 9/L were reported and attributed to the leukapheresis procedure.
Slovenian: 9/l, kar so pripisovali postopku levkafereze.
English: It is important to tell your doctor if you:
Slovenian: Pomembno je, da zdravniku poveste:
English: Do not use Grastofil if you notice it is cloudy, or there is discoloration or there are particles in it.
Slovenian: Ne uporabljajte zdravila Grastofil, če opazite, da je raztopina motna, razbarvana ali so v njej delci.
English: 9/L for 3 consecutive days
Slovenian: 9/l v obdobju 3 zaporednih dni
English: A meta-analysis of allogeneic transplant studies, including the results of nine prospective randomised studies, 8 retrospective studies and 1 case-controlled study, did not detect an effect on the risks of acute GvHD, chronic GvHD or early treatment-related mortality.
Slovenian: Meta-analiza študij alogenskih presaditev, vključno z rezultati devetih prospektivnih randomiziranih študij, 8 retrospektivnih študij in 1 s primeri nadzirane študije ni pokazala vpliva na tveganje akutne GvHD, kronične GvHD ali z zgodnjim zdravljenjem povezane smrtnosti.
English: What Grastofil is and what it is used for What you need to know before you use Grastofil How to use Grastofil
Slovenian: Kaj je zdravilo Grastofil in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Grastofil Kako uporabljati zdravilo Grastofil Možni neželeni učinki
English: Each mL of solution contains 50 mg of sorbitol (E420) (see section 4.4).
Slovenian: En ml raztopine vsebuje 50 mg sorbitola (E420) (glejte poglavje 4.4).
English: Your doctor may then test your blood to see how well the treatment is working and how long it should last.
Slovenian: Potem bo morda zdravnik opravil krvno preiskavo, da ugotovi, kako dobro deluje zdravljenje in kako dolgo naj traja.
English: The mechanism of vasculitis in patients receiving filgrastim is unknown.
Slovenian: Mehanizem vaskulitisa pri bolnikih, ki dobivajo filgrastim, ni znan.
English: If more than one leukapheresis is required, particular attention should be paid to donors with platelets < 100 x 10
Slovenian: Če je potrebna več kot ena levkafereza, je treba posebno pozornost nameniti darovalcem, pri katerih število trombocitov pred levkaferezo znaša < 100 x 10
English: If you have missed an injection, contact your doctor as soon as possible.
Slovenian: Če si pozabite injicirati zdravilo, se čimprej obrnite na zdravnika.
English: The safety and efficacy in neonates and patients with autoimmune neutropenia have not been established.
Slovenian: Varnost in učinkovitost pri novorojenčkih in bolnikih z avtoimunsko nevtropenijo nista bili dokazani.
English: When reversal of neutropenia has been achieved, the minimal effective dose to maintain a normal neutrophil count should be established.
Slovenian: Ko je nevtropenija odpravljena, je treba določiti najmanjši učinkoviti odmerek za vzdrževanje normalnega števila nevtrofilcev.
English: Use of filgrastim in patients with HIV infection maintains normal neutrophil counts to allow scheduled dosing of antiviral and/or other myelosuppressive treatments.
Slovenian: Uporaba filgrastima pri bolnikih, okuženih s HIV, vzdržuje normalno število nevtrofilcev, kar omogoča načrtovano odmerjanje protivirusnih in/ali drugih mielosupresivnih načinov zdravljenja.
English: CLONMEL Healthcare Ltd. Telephone +353/52.61.77.777
Slovenian: CLONMEL Healthcare Ltd. Tel:+ 353/52.61.77.777
English: The impact of filgrastim on human fertility is not known.
Slovenian: Vpliv filgrastima na plodnost pri ljudeh ni znan.
English: Statistical analysis of the relationship between the number of CD34
Slovenian: Statistična analiza odnosa med številom ponovno infundiranih celic CD34
English: Filgrastim did not affect reproductive performance or fertility in male or female rats (see section 5.3).
Slovenian: Filgrastim ni vplival na sposobnost razmnoževanja ali plodnost pri podganjih samcih ali samicah (glejte poglavje 5.3).
English: Generally, events of glomerulonephritis resolved after dose reduction or withdrawal of filgrastim and pegfilgrastim.
Slovenian: Na splošno so dogodki glomerulonefritisa z zmanjšanjem odmerka ali prenehanjem uporabe filgrastima in pegfilgrastima izzveneli.
English: Your doctor has prescribed Grastofil, which is used to treat neutropenia (nu-tro-peen-ee-ah), a condition where the body makes too few neutrophils.
Slovenian: Zdravnik vam je predpisal zdravilo Grastofil, ki se uporablja za zdravljenje nevtropenije, bolezni, pri kateri telo tvori premalo nevtrofilcev.
English: Your doctor will tell you why you are being treated with Grastofil.
Slovenian: Zdravnik vam bo povedal, zakaj se zdravite z zdravilom Grastofil.
English: Grastofil is a biosimilar medicinal product.
Slovenian: Zdravilo Grastofil je biološko podobno zdravilo.
English: Following termination of filgrastim therapy, circulating neutrophil counts decrease by 50% within 1 to 2 days, and to normal levels within 1 to 7 days.
Slovenian: Po koncu zdravljenja s filgrastimom se število nevtrofilcev v obtoku v 1 do 2 dneh zmanjša za 50 %, na normalno raven pa se povrne v 1 do 7 dneh.
English: • Inflammation of the aorta (the large blood vessel which transports blood from the heart to the body), see section 2.
Slovenian: • Vnetje aorte (velike žile, ki prenaša kri od srca po telesu), glejte poglavje 2.