FrancophonIA/ELRC3.0 huggingface dataset:
English: High HCTZ use (≥50,000 mg cumulative) was associated with an adjusted OR of 1.29 (95% CI: 1.231.35) for BCC and 3.98 (95% CI: 3.68-4.31) for SCC.
Danish: Stort forbrug af hydrochlorthiazid (≥ 50.000 mg kumulativt) var forbundet med en justeret OR-værdi på 1,29 (95 %-KI: 1,23-1,35) for basalcellekarcinom og på 3,98 (95 %KI: 3,68-4,31) for pladecellekarcinom.
English: If you are intolerant to some sugars, consult your doctor before taking MicardisPlus.
Danish: Hvis du ikke tåler disse sukkerarter, bør du kontakte din læge, før du tager MicardisPlus.
English: MicardisPlus is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Danish: Det frarådes at anvende MicardisPlus under graviditeten, og det må ikke tages senere end 3 måneder henne i graviditeten, da det kan forårsage alvorlige fosterskader.
English: There is no experience regarding the administration of MicardisPlus in patients with recent kidney transplantation.
Danish: Der er ingen erfaring med anvendelse af MicardisPlus til patienter, der kort tid forinden har fået foretaget en nyretransplantation.
English: In the "Prevention Regimen For Effectively avoiding Second Strokes" (PRoFESS) trial in patients 50 years and older, who recently experienced stroke, an increased incidence of sepsis was noted for telmisartan compared with placebo, 0.70 % vs. 0.49 % [RR 1.43 (95 % confidence interval 1.002.06)]; the incidence of fatal sepsis cases was increased for patients taking telmisartan (0.33 %) vs. patients taking placebo (0.16 %) [RR 2.07 (95 % confidence interval 1.14 - 3.76)].
Danish: I forsøget "Prevention Regimen For Effectively avoiding Second Strokes" (PRoFESS) hos patienter på 50 år og ældre, som for nylig har oplevet stroke, blev der observeret en øget incidens af sepsis hos patienter behandlet med telmisartan sammenlignet med placebo, 0,70 % vs 0,49 % [RR 1,43 (95 % sikkerhedsinterval 1,00-2,06)]; incidensen af letale sepsistilfælde var øget hos patienter, som fik telmisartan (0,33 %) vs. patienter, som fik placebo (0,16 %) [RR 2,07 (95 % sikkerhedsinterval 1,14-3,76)].
English: Adverse reactions of unknown frequency reported with the use of hydrochlorothiazide alone include:
Danish: Følgende bivirkninger af ukendt hyppighed er rapporteret ved brug af hydrochlorthiazid alene:
English: • if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Danish: • hvis du har sukkersyge eller nedsat nyrefunktion, og du også tager et blodtrykssænkende lægemiddel,
English: - aliskiren.
Danish: der indeholder aliskiren.
English: The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium.
Danish: Hydrochlorthiazids diuretiske virkning reducerer plasmavolumen, øger plasmareninaktiviteten og aldosteronsekretionen, med deraf følgende øget udskillelse af kalium og bikarbonat i urinen, samt sænket serumkalium.
English: MicardisPlus should be taken in patients whose blood pressure is not adequately controlled by telmisartan alone.
Danish: MicardisPlus gives, hvis blodtrykket ikke kan reguleres tilfredsstillende med telmisartan alene.
English: Children and adolescents The use of MicardisPlus in children and adolescents up to the age of 18 years is not recommended.
Danish: Børn og unge MicardisPlus bør ikke ordineres til børn og unge under 18 år.
English: MicardisPlus must not be used in patients with severe renal impairment (creatinine clearance <30 ml/min) (see section 4.3).
Danish: MicardisPlus må ikke anvendes til patienter med svært nedsat nyrefunktion (kreatinin-clearance <30 ml/min).
English: There is no clinical experience with MicardisPlus in patients with hepatic impairment.
Danish: Der er ingen klinisk erfaring med brug af MicardisPlus til patienter med nedsat leverfunktion.
English: You can take MicardisPlus with or without food.
Danish: Brug af MicardisPlus sammen med mad og alkohol Du kan tage MicardisPlus med eller uden mad.
English: No statistically significant difference in the incidence of the primary composite endpoint (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for congestive heart failure) was found [15.7 % in the telmisartan and 17.0 % in the placebo groups with a hazard ratio of 0.92 (95 % CI 0.81 - 1.05, p = 0.22)].
Danish: Der blev ikke fundet statistisk signifikant forskel i det primære sammensatte endepunkt (kardiovaskulær død, ikke-letalt myokardieinfarkt, ikke-letal apopleksi eller hospitalsindlæggelse pga. hjertesvigt) [15,7 % i telmisartangruppen og 17,0 % i placebogruppen med en hazard ratio på 0,92 (95 % CI 0,81-1,05; p = 0,22)].
English: Adverse reactions reported in all clinical trials and occurring more frequently (p 0.05) with telmisartan plus hydrochlorothiazide than with placebo are shown below according to system organ class.
Danish: Tabellen nedenfor viser de bivirkninger, der forekom hyppigere (p  0,05) for telmisartan plus hydrochlorthiazid end for placebo i de kliniske forsøg.
English: What you need to know before you take MicardisPlus
Danish: Det skal du vide, før du begynder at tage MicardisPlus
English: MicardisPlus fixed dose combination (40 mg telmisartan/12.5 mg hydrochlorothiazide and 80 mg telmisartan/12.5 mg hydrochlorothiazide) is indicated in adults whose blood pressure is not adequately controlled on telmisartan alone.
Danish: Fastdosiskombinationen MicardisPlus (40 mg telmisartan/12,5 mg hydrochlorthiazid og 80 mg telmisartan/12,5 mg hydrochlorthiazid) er indiceret til voksne, hvis blodtryk ikke kan reguleres tilfredsstillende med telmisartan alene.
English: The overall incidence of adverse reactions reported with MicardisPlus was comparable to those reported with telmisartan alone in randomised controlled trials involving 1471 patients randomised to receive telmisartan plus hydrochlorothiazide (835) or telmisartan alone (636).
Danish: I randomiserede, kontrollerede forsøg med alt i alt 1471 patienter, var den totale rapporterede forekomst af bivirkninger ved brug af MicardisPlus (835 patienter) sammenlignelig med forekomsten for telmisartan alene (636 patienter).
English: • MicardisPlus 40 mg/12.5 mg may be administered once daily in patients whose blood pressure is not adequately controlled by Micardis 40 mg
Danish: • MicardisPlus 40 mg/12,5 mg én gang dagligt er til patienter, hvis blodtryk ikke kan reguleres tilfredsstillende med Micardis 40 mg
English: 14 tablets 28 tablets 30 x 1 tablets 56 tablets 90 x 1 tablets 98 tablets 28 x 1 tablets
Danish: 14 tabletter 28 tabletter 30 x 1 tabletter 56 tabletter 90 x 1 tabletter 98 tabletter 28 x 1 tabletter
English: MicardisPlus is not indicated in patients with severe hepatic impairment.
Danish: MicardisPlus må ikke gives til patienter med svært nedsat leverfunktion.
English: 14 tablets 28 tablets 30 x 1 tablets 56 tablets 84 tablets 90 x 1 tablets 98 tablets 28 x 1 tablets
Danish: 14 tabletter 28 tabletter 30 x 1 tabletter 56 tabletter 84 tabletter 90 x 1 tabletter 98 tabletter 28 x 1 tabletter
English: Adverse reactions previously reported with one of the individual components may be potential adverse reactions with MicardisPlus, even if not observed in clinical trials with this product.
Danish: Tidligere rapporterede bivirkninger for de enkelte indholdsstoffer kan også være potentielle bivirkninger i forbindelse med MicardisPlus, selvom de ikke er observeret i kliniske forsøg med dette produkt.
English: - Hyponatraemia and hypochloraemic alkalosis There is no evidence that MicardisPlus would reduce or prevent diuretic-induced hyponatraemia.
Danish: Der er intet, der tyder på, at MicardisPlus kan reducere eller forhindre diuretika forårsaget hyponatriæmi.
English: When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started.
Danish: I tilfælde af graviditet bør behandling med angiotensin IIreceptorantagonister straks seponeres, og alternativ behandling påbegyndes.
English: In a double-blind controlled clinical trial (n=687 patients evaluated for efficacy) in non-responders to the 80 mg/12.5 mg combination, an incremental blood pressure lowering effect of the 80 mg/25 mg combination compared to continued treatment with the 80 mg/12.5 mg combination of 2.7/1.6 mm Hg (SBP/DBP) was demonstrated (difference in adjusted mean changes from baseline).
Danish: I et dobbeltblindt kontrolleret klinisk studie (n=687 patienter evalueret for effekt) hos non-respondenter i forhold til 80 mg/12,5 mg kombinationen, blev der påvist en øget blodtryktssænkende effekt ved behandling med 80 mg/25 mg kombinationen sammenlignet med fortsat behandling med 80 mg/12,5 mg kombinationen på 2,7/1,6 mm Hg (SBP/DBP).
English: Infections and infestations Not known:
Danish: Infektioner og parasitære sygdomme Ikke kendt:
English: MicardisPlus is used to treat high blood pressure (essential hypertension) in adults whose blood pressure is not controlled enough when telmisartan is used alone.
Danish: MicardisPlus bruges til at sænke forhøjet blodtryk (essentiel hypertension) hos voksne, hvis blodtryk ikke er sænket tilstrækkeligt med telmisartan.
English: • At the request of the European Medicines Agency;
Danish: En opdateret RMP skal desuden fremsendes: • på anmodning fra Det Europæiske Lægemiddelagentur
English: This can lead to permanent vision impairment, if not treated.
Danish: Hvis det ikke behandles, kan det føre til permanent nedsat syn.
English: Hydrochlorothiazide In patients taking hydrochlorothiazide alone the following additional side effects have been reported:
Danish: Hos patienter, der kun får hydrochlorthiazid, er der, i tillæg til de bivirkninger, som er nævnt for MicardisPlus, set følgende bivirkninger:
English: Jaundice hepatocellular, jaundice cholestatic
Danish: Hepatocellulær gulsot, kolestatisk gulsot
English: Should exposure to angiotensin II receptor antagonists have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Danish: Hvis angiotensin II-receptorantagonister har været anvendt fra andet trimester, bør nyrefunktionen og kraniet kontrolleres ved hjælp af ultralyd.
English: D-55216 Ingelheim am Rhein Germany and
Danish: D-55216 Ingelheim am Rhein og
English: • MicardisPlus 80 mg/12.5 mg may be administered once daily in patients whose blood pressure is not adequately controlled by Micardis 80 mg
Danish: • MicardisPlus 80 mg/12,5 mg én gang dagligt er til patienter, hvis blodtryk ikke kan reguleres tilfredsstillende med Micardis 80 mg.
English: NAME OF THE MEDICINAL PRODUCT MicardisPlus 80 mg/25 mg tablets
Danish: LÆGEMIDLETS NAVN MicardisPlus 80 mg/25 mg tabletter
English: - Hypokalaemia
Danish: Hypomagnesiæmi
English: Investigations Uncommon: Rare:
Danish: Ikke almindelig: Sjælden:
English: Symptomatic hypotension, especially after the first dose, may occur in patients who are volume and/or sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting.
Danish: Intravaskulær hypovolæmi: Specielt efter første dosis kan der forekomme symptomatisk hypotension hos patienter, som har for lavt volumen i blodbanen eller natriummangel på grund af kraftig diuretisk behandling, saltfattig diæt, diarré eller opkastning.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Unit dose blister 7 or 10-count or any non 7 count blister
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP Unit dose blister 7 eller 10- og andre blisterkort bortset fra 7 styk blisterkort
English: You should store your medicine in the original package in order to protect the tablets from moisture.
Danish: Du skal opbevare MicardisPlus i den originale yderpakning for at beskytte tabletterne mod fugt.
English: Blood and lymphatic system disorders Uncommon: Rare:
Danish: Blod og lymfesystem Ikke almindelig: Sjælden
English: MicardisPlus should not be given to patients with cholestasis, biliary obstructive disorders or severe hepatic insufficiency (see section 4.3) since telmisartan is mostly eliminated with the bile.
Danish: MicardisPlus bør ikke gives til patienter med kolestase, biliære obstruktive sygdomme eller svær leverinsufficiens (se pkt.
English: What MicardisPlus contains
Danish: MicardisPlus indeholder:
English: Not all pack sizes may be available in your country.
Danish: Ikke alle pakningsstørrelser er nødvendigvis markedsførti ditland.
English: The effect of MicardisPlus may be reduced when you take NSAIDs (non-steroidal anti-inflammatory medicines, e.g. aspirin or ibuprofen).
Danish: Blodtrykssænkningen med MicardisPlus kan blive mindre ved samtidig brug af medicin mod gigt og lette smerter (non-steroid antiinflammatorisk medicin (NSAID)), f.eks. acetylsalicylsyre eller ibuprofen.
English: MicardisPlus is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Danish: Hvis MicardisPlus tages mere end 3 måneder henne i graviditeten, kan det forårsage alvorlige fosterskader (se afsnit Graviditet).
English: Adverse reactions reported with one of the individual components may be potential adverse reactions with MicardisPlus, even if not observed in clinical trials with this product.
Danish: Nedenstående bivirkninger, der er blevet rapporteret for de to aktive indholdsstoffer, er også mulige bivirkninger for MicardisPlus, selvom de ikke er set i kliniske studier med dette lægemiddel.
English: MicardisPlus 80 mg/25 mg may be administered once daily in patients whose blood pressure is not adequately controlled by MicardisPlus 80 mg/12.5 mg or in patients who have been previously stabilised on telmisartan and hydrochlorothiazide given separately.
Danish: MicardisPlus 80 mg/25 mg én gang dagligt kan gives til patienter, hvis blodtryk ikke kan reguleres tilfredsstillende med Micardis 80 mg/12,5 mg eller til patienter, som tidligere er stabiliseret på telmisartan og hydrochlorothiazid givet hver for sig.
English: INFORMATION IN BRAILLE MicardisPlus 80 mg/25 mg
Danish: INFORMATION I BRAILLESKRIFT MicardisPlus 80 mg/25 mg
English: MicardisPlus is used to treat high blood pressure (essential hypertension) in adults whose blood pressure is not adequately controlled by MicardisPlus 80/12.5 mg or in patients who have been previously stabilised by telmisartan and hydrochlorothiazide given separately.
Danish: MicardisPlus bruges til at sænke forhøjet blodtryk (essentiel hypertension) hos voksne, hvis blodtryk ikke kan reguleres tilfredsstillende med MicardisPlus 80 mg/12,5 mg eller til patienter, som tidligere er stabiliseret på telmisartan og hydrochlorothiazid givet hver for sig.
English: MicardisPlus 80 mg/25 mg tablets are yellow and white, oval-shaped, two-layer tablets engraved with the company logo and the code 'H9'.
Danish: MicardisPlus 80 mg/25 mg tabletten er gul og hvid, oval og er i 2 lag hvorpå firmaets logo og koden ”H9” er præget.
English: Low platelet count (thrombocytopenia), increase in certain white blood cells (eosinophilia), serious allergic reaction (e.g. hypersensitivity, anaphylactic reaction, drug rash), low blood sugar levels (in diabetic patients), upset stomach, eczema (a skin disorder), arthrosis, inflammation of the tendons, decreased haemoglobin (a blood protein), somnolence.
Danish: Lavt blodpladetal (trombocytopeni), øget mængde hvide blodlegemer (eosinofili), alvorlig allergisk reaktion (f.eks. overfølsomhed, anafylaktisk reaktion, lægemiddelfremkaldt udslæt), lavt blodsukker (hos diabetes patienter), maveproblemer, eksem, slidgigt, senebetændelse, nedsat hæmoglobin (et blodprotein), søvnighed.
English: Sepsis* (often called "blood poisoning"), is a severe infection with whole-body inflammatory response, rapid swelling of the skin and mucosa (angioedema), blistering and peeling of the top layer of skin (toxic epidermal necrolysis); these side effects are rare (may affect up to 1 in 1,000 people) or of unknown frequency (toxic epidermal necrolysis)but are extremely serious and patients should stop taking the medicine and see their doctor immediately.
Danish: Sepsis* (ofte kaldet "blodforgiftning") er en alvorlig infektion med betændelsesreaktion i hele kroppen, hurtig hævelse af hud og slimhinder (angioødem), blærer og afskalning af det øverste lag af huden (toksisk epidermal nekrolyse).
English: Other medicines and MicardisPlus:
Danish: Brug af anden medicin sammen med MicardisPlus
English: - class Ia antiarrythmics (e.g. quinidine, hydroquinidine, disopyramide) - class III antiarrythmics (e.g. amiodarone, sotalol, dofetilide, ibutilide) - some antipsychotics (e.g. thioridazine, chlorpromazine, levomepromazine, trifluoperazine,
Danish: - klasse 1a-antiarytmika, (fx quinidin, hydroquinidin, disopyramid) - klasse 3-antiarytmika, (fx amiodaron, sotalol, doftilid, ibutilid) - visse antipsykotika (fx thioridazin, chlorpromazin, levomepromazin, trifluoperazin, cyamemazin, sulpirid, sultoprid, amisulprid, tiaprid, pimozid, haloperidol, droperidol) - andre (fx bepridil, cisaprid, diphemanil, erythromycin i.v., halofantrin, mizolastin, pentamidin, sparfloxacin, terfenadin, vincamin i.v.)
English: INFORMATION IN BRAILLE MicardisPlus 40 mg/12.5 mg
Danish: INFORMATION I BRAILLESKRIFT MicardisPlus 40 mg/12,5 mg
English: How to take MicardisPlus
Danish: Sådan skal du tage MicardisPlus
English: Conversely, due to the antagonism of the angiotensin II (AT1) receptors by the telmisartan component of MicardisPlus, hyperkalaemia might occur.
Danish: Omvendt kan hyperkaliæmi optræde på grund af telmisartans antagonistiske effekt på angiotensin II (AT1)receptorerne.
English: MicardisPlus 80 mg/12.5 mg tablets
Danish: MicardisPlus 80 mg/12,5 mg tabletter
English: MicardisPlus 40 mg/12.5 mg tablets Each tablet contains 40 mg telmisartan and 12.5 mg hydrochlorothiazide.
Danish: MicardisPlus 40 mg/12,5 mg tabletter Én tablet indeholder 40 mg telmisartan og 12,5 mg hydrochlorthiazid.
English: An increase in cholesterol and triglyceride levels has been associated with thiazide diuretic therapy; however, at the 12.5 mg dose contained in MicardisPlus, minimal or no effects were reported.
Danish: Der er dog kun rapporteret om minimal eller ingen påvirkning ved den mængde thiazid (12,5 mg), som findes i MicardisPlus.
English: MicardisPlus fixed dose combination (80 mg telmisartan/25 mg hydrochlorothiazide) is indicated in adults whose blood pressure is not adequately controlled on MicardisPlus 80 mg/12.5 mg (80 mg telmisartan/12.5 mg hydrochlorothiazide) or adults who have been previously stabilised on telmisartan and hydrochlorothiazide given separately.
Danish: I fastdosiskombinationen er MicardisPlus (80 mg telmisartan/25 mg hydrochlorthiazid) indiceret til voksne, hvis blodtryk ikke kan reguleres tilfredsstillende med MicardisPlus 80 mg/12,5 mg (80 mg telmisartan/12,5 mg hydrochlorothiazid) eller til patienter, som tidligere er stabiliseret på telmisartan og hydrochlorothiazid givet hver for sig.
English: MicardisPlus 80 mg/12.5 mg tablets Each tablet contains 80 mg telmisartan and 12.5 mg hydrochlorothiazide.
Danish: MicardisPlus 80 mg/12,5 mg tabletter Én tablet indeholder 80 mg telmisartan og 12,5 mg hydrochlorthiazid.
English: MicardisPlus 40 mg/12.5 mg tablets are red and white, oval-shaped two-layer tablets engraved with the company logo and the code 'H4'.
Danish: MicardisPlus 40 mg/12,5 mg tabletten er rød og hvid, oval og er i 2 lag hvorpå firmaets logo og koden ”H4” er præget.
English: MicardisPlus 40 mg/12.5 mg tablets
Danish: MicardisPlus 40 mg/12,5 mg tabletter
English: MicardisPlus 80 mg/12.5 mg tablets are red and white, oval-shaped, two-layer tablets engraved with the company logo and the code 'H8'.
Danish: MicardisPlus 80 mg/12,5 mg tabletten er rød og hvid, oval og er i 2 lag hvorpå firmaets logo og koden ”H8” er præget.
English: Somnolence Respiratory, thoracic and mediastinal disorders Uncommon: Very rare:
Danish: Luftveje, thorax og mediastinum Ikke almindelig: Sjælden:
English: INFORMATION IN BRAILLE MicardisPlus 80 mg/12.5 mg
Danish: INFORMATION I BRAILLESKRIFT MicardisPlus 80 mg/12,5 mg
English: The overall incidence and pattern of adverse reactions reported with MicardisPlus 80 mg/25 mg was comparable with MicardisPlus 80 mg/12.5 mg. A dose-relationship of adverse reactions was not established and they showed no correlation with gender, age or race of the patients.
Danish: Den totale incidens og mønster af bivirkninger rapporteret ved brug af MicardisPlus 80 mg/25 mg var sammenlignelig med MicardisPlus 80 mg/12,5 mg.
English: You should consult with your doctor if you need to adjust the dose of your other medicine while taking MicardisPlus.
Danish: Du skal derfor tale med din læge om eventuelt at få ændret doseringen af din medicin.
English: MicardisPlus is also available at the dose strengths 40 mg/12.5 mg and 80 mg/ 12.5 mg Renal impairment
Danish: MicardisPlus findes i styrkerne 40 mg/12,5 mg og 80 mg/12,5 mg.
English: The use of MicardisPlus during breast feeding is not recommended.
Danish: Det frarådes at anvende MicardisPlus i ammeperioden.
English: Upper respiratory tract infection (e.g. sore throat, inflamed sinuses, common cold), urinary tract infections, deficiency in red blood cells (anaemia), high potassium levels, slow heart rate (bradycardia), kidney impairment including acute kidney failure, weakness, cough.
Danish: Ikke almindelige bivirkninger (kan forekomme hos op til 1 ud af 100 brugere): Øvre luftvejsinfektion (f.eks. ondt i halsen, bihulebetændelse, almindelig forkølelse), urinvejsinfektion, blodmangel (anæmi), høje kaliumniveauer, langsom hjerterytme (bradykardi), nedsat nyrefunktion inklusive akut nyresvigt, svaghed, hoste.
English: Because no information is available regarding the use of MicardisPlus during breast-feeding, MicardisPlus is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
Danish: Som alternativ anbefales behandlingsregimer med bedre etablerede sikkerhedsprofiler ved amning, specielt ved amning af nyfødte og præmature spædbørn.
English: ONTARGET (ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) compared the effects of telmisartan, ramipril and the combination of telmisartan and ramipril on cardiovascular outcomes in 25620 patients aged 55 years or older with a history of coronary artery disease, stroke, TIA, peripheral arterial disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage (e.g. retinopathy, left ventricular hypertrophy, macro- or microalbuminuria), which is a population at risk for cardiovascular events.
Danish: De var 55 år eller ældre og havde en anamnese med koronararteriesygdom, apopleksi, transitorisk cerebral iskæmi (TCI), perifer arteriel sygdom eller diabetes mellitus type 2 med organpåvirkning (f.eks. retinopati, venstre ventrikel hypertrofi, makro- eller mikroalbuminuri).
English: Telmisartan was found to be similarly effective to ramipril in the pre-specified secondary endpoint of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke [0.99 (97.5 % CI 0.901.08), p (non-inferiority) = 0.0004], the primary endpoint in the reference study HOPE (The Heart Outcomes Prevention Evaluation Study), which had investigated the effect of ramipril vs. placebo.
Danish: Mht. det prædefinerede sekundære endepunkt (reduktion af kardiovaskulær død, ikke-letalt myokardieinfarkt og ikke-letal apopleksi) - som var identisk med det primære endepunkt i HOPE-studiet (The Heart Outcomes Prevention Evaluation Study) - blev telmisartan fundet ligeværdigt med ramipril [0,99 (97,5 % CI 0,90-1,08; p (non-inferioritet) = 0,0004)].