FrancophonIA/ELRC3.0 huggingface dataset:
English: After starting treatment, the immune system becomes stronger, and may attack the infections, which can cause symptoms of infection or inflammation.
Slovenian: Ko se začne zdravljenje, se imunski sistem okrepi, tako da se telo začne boriti proti okužbam, kar lahko privede do simptomov okužbe ali vnetja.
English: • lack of energy (fatigue)
Slovenian: • pomanjkanje energije (utrujenost)
English: Taking Dovato at the time of becoming pregnant or during the first twelve weeks of pregnancy, may increase the risk of a birth defect, called neural tube defect, such as spina bifida (malformed spinal cord).
Slovenian: Jemanje zdravila Dovato ob zanositvi ali v prvih dvanajstih tednih nosečnosti lahko poveča tveganje za prirojeno napako, imenovano okvara nevralne cevi, kot je spina bifida (nepravilno oblikovana hrbtenjača).
English: Dolutegravir and lamivudine are present in cerebrospinal fluid (CSF).
Slovenian: Dolutegravir in lamivudin sta prisotna v cerebrospinalni tekočini (CST).
English: Inhibition of OAT3 has not been studied in vivo.
Slovenian: Zaviranja OAT3 in vivo niso raziskovali.
English: Clinical status including liver aminotransferases and bilirubin should be monitored.
Slovenian: Potrebno je spremljati klinično stanje, vključno z jetrnimi aminotransferazami in bilirubinom.
English: • increase in the level of enzymes produced in the muscles (creatine phosphokinase).
Slovenian: • zvišane vrednosti encimov, ki nastajajo v mišicah (kreatin fosfokinaza).
English: The concentration of active substance necessary to effect viral replication by 50% (IC50 - half maximal inhibitory concentration) varied according to virus and host cell type.
Slovenian: Koncentracija učinkovine, potrebna za 50% učinek na replikacijo virusov (IC50 - polovična maksimalna inhibitorna koncentracija), se je razlikovala glede na virus in tip gostiteljske celice.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Slovenian: V študijah na živalih lamivudin ni pokazal teratogenih učinkov, obstajajo pa indikacije za povečano zgodnjo embrionalno smrtnost kuncev, in to že pri relativno nizkih sistemskih izpostavljenostih, ki so primerljive s tistimi doseženimi pri ljudeh.
English: Total blood and plasma drugrelated radioactivity concentration ratios averaged between 0.441 to 0.535, indicating minimal association of radioactivity with blood cellular components.
Slovenian: Celotno razmerje koncentracije z zdravilom povezane radioaktivnosti v krvi in plazmi je povprečno med 0,441 in 0,535, kar kaže na minimalno povezavo med radioaktivnostjo in celičnimi komponentami krvi.
English: Rare side effects that may show up in blood tests are: • increase in an enzyme called amylase.
Slovenian: Redki neželeni učinki, ki se lahko pokažejo v preiskavah krvi, so: • povečana vrednost encima, imenovanega amilaza.
English: • increase in the level of liver enzymes (aminotransferases)
Slovenian: • zvišane vrednosti jetrnih encimov (aminotransferaza)
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breastfed infants of mothers treated for HIV are very low (< 4% of maternal serum concentrations) and progressively decrease to undetectable levels when breastfed infants reach 24 weeks of age.
Slovenian: Na podlagi podatkov pri več kot 200 parih mater in otrok, zdravljenih zaradi okužbe s HIV, so koncentracije lamivudina v serumu dojenih otrok mater, zdravljenih zaradi okužbe s HIV, zelo majhne (manj kot 4 % koncentracije v materinem serumu) in se progresivno zmanjšujejo do nezaznavne ravni, ko dojeni otroci dosežejo 24 tednov starosti.
English: The safety and efficacy of a dual regimen has not been studied in pregnancy.
Slovenian: Varnost in učinkovitost zdravljenja s shemo z dvema učinkovinama v nosečnosti nista bili preučevani.
English: Look out for important symptoms Some people taking medicines for HIV infection develop other conditions, which can be serious.
Slovenian: Bodite pozorni na pomembne simptome Pri nekaterih bolnikih, ki jemljejo zdravila za zdravljenje okužbe s HIV, se razvijejo določena stanja, ki so lahko resna.
English: → Ask your doctor for advice before taking this medicine.
Slovenian: → Posvetujte se z zdravnikom pred začetkom jemanja tega zdravila.
English: Fifty-three percent of total oral dose is excreted unchanged in the faeces.
Slovenian: Triinpetdeset odstotkov celotnega peroralnega odmerka se nespremenjenega izloči z blatom.
English: With this condition, parts of the bone tissue are permanently damaged because of reduced blood supply to the bone.
Slovenian: Pri tej bolezni so deli kostnega tkiva trajno poškodovani zaradi zmanjšane prekrvitve kosti.
English: Animal studies showed lamivudine may inhibit cellular DNA replication (see section 5.3).
Slovenian: Študije na živalih so pokazale, da lahko lamivudin inhibira replikacijo celične DNK (glejte poglavje 5.3).
English: A small amount of the ingredients in Dovato can also pass into your breast milk.
Slovenian: Majhna količina sestavin zdravila Dovato lahko prehaja v materino mleko.
English: • lactic acidosis (excess lactic acid in the blood)
Slovenian: • laktacidoza (čezmerno kopičenje mlečne kisline v krvi),
English: Dovato is used to treat HIV in adults and adolescents over 12 years old who weigh at least 40 kg.
Slovenian: Zdravilo Dovato se uporablja za zdravljenje okužbe z virusom HIV pri odraslih in mladostnikih, starejših od 12 let, ki tehtajo vsaj 40 kg.
English: Dolutegravir has not been studied in patients on dialysis, though differences in exposure are not expected.
Slovenian: Dolutegravirja pri bolnikih na dializi niso raziskali, vendar pa razlik v izpostavljenosti ni pričakovati.
English: • if their immune systems are very weak
Slovenian: • ki imajo zelo oslabljen imunski sistem,
English: → Tell your doctor or pharmacist if you are taking any of these.
Slovenian: → Obvestite zdravnika ali farmacevta, če jemljete kar koli od navedenega.
English: Dolutegravir can cause a serious allergic reaction known as a hypersensitivity reaction.
Slovenian: Dolutegravir lahko povzroči hudo alergijsko reakcijo, tako imenovano preobčutljivostno reakcijo.
English: Co-infection with Hepatitis B or C
Slovenian: Sočasna okužba s hepatitisom B ali C
English: This increase is not considered clinically relevant.
Slovenian: To povečanje se ne smatra kot klinično pomembno.
English: The true extent of CNS penetration of lamivudine and its relationship with any clinical efficacy is unknown.
Slovenian: Dejanski obseg penetracije lamivudina v CŽS in korelacija s klinično učinkovitostjo nista znana.
English: Patients should be informed that dizziness and somnolence has been reported during treatment with dolutegravir.
Slovenian: Bolnike je treba obvestiti, da so med zdravljenjem z dolutegravirjem poročali o omotici in zaspanosti.
English: For patients receiving lamivudine 300 mg once daily, the terminal intracellular half-life of lamivudine-TP was 16 to 19 hours.
Slovenian: Pri bolnikih, ki so prejemali 300 mg lamivudina enkrat dnevno, je bil končni znotrajcelični razpolovni čas izločanja lamivudina-TP 16 do 19 ur.
English: This was supported by the pooled analysis, see Table 3.
Slovenian: To je potrdila združena analiza, glejte preglednico 3.
English: The apparent volume of distribution of dolutegravir (Vd/F) is 17-20 L. Intravenous studies with lamivudine showed that the mean apparent volume of distribution is 1.3 L/kg.
Slovenian: Navidezni volumen porazdelitve dolutegravirja (Vd/F) je 17-20 l. Študije z intravensko danim lamivudinom so pokazale, da znaša srednji navidezni volumen porazdelitve 1,3 l/kg.
English: Patients should be advised that dolutegravir, lamivudine or any other antiretroviral therapy does not cure HIV infection and that they may still develop opportunistic infections and other complications of HIV infection.
Slovenian: Bolnike je treba opozoriti, da dolutegravir, lamivudin ali katera koli druga protiretrovirusna terapija ne ozdravi okužbe s HIV in da se lahko pri njih vseeno pojavijo oportunistične okužbe in drugi s HIV povezani zapleti.
English: Relevant examples are Cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jirovecii pneumonia (often referred to as PCP).
Slovenian: Tovrstni primeri so citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami in s Pneumocystis jirovecii povzročena pljučnica (pogosto omenjena kot PCP).
English: If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered.
Slovenian: Če se pri teh bolnikih opazi poslabšanje jetrne bolezni, je treba razmisliti o začasni prekinitvi ali trajni ukinitvi zdravljenja.
English: No dose adjustment is necessary (see section 5.2).
Slovenian: Prilagoditev odmerka ni potrebna (glejte poglavje 5.2).
English: In vitro lamivudine inhibits the intracellular phosphorylation of cladribine leading to a potential risk of cladribine loss of efficacy in case of combination in the clinical setting.
Slovenian: In vitro lamivudin zavira znotrajcelično fosforilacijo kladribina in tako ustvarja možno tveganje za izgubo učinkovitosti kladribina v primeru kombinirane klinične uporabe.
English: → Read the information ‘Other possible side effects' in section 4 of this leaflet.
Slovenian: → Preberite odstavek “Drugi možni neželeni učinki” v poglavju 4 tega navodila.
English: Trimethoprim (an inhibitor of these transporters) has been shown to increase lamivudine plasma concentrations, however the resulting increase was not clinically significant (see Table 1).
Slovenian: Trimetoprim (zaviralec teh prenašalcev) poveča koncentracijo lamivudina v plazmi, vendar posledično povečanje ni bilo klinično pomembno (glejte Preglednico 1).
English: Increases in serum creatinine occurred within the first four weeks of treatment with dolutegravir plus lamivudine and remained stable through 48 weeks.
Slovenian: Zvišane vrednosti serumskega kreatinina so se pojavile v prvih štirih tednih zdravljenja z dolutegravirjem in lamivudinom ter so ostale nespremenjene skozi 48 tednov.
English: Investigations: Common:
Slovenian: Preiskave: pogosti:
English: This antiviral response was maintained for 3 to 4 days after the last dose in the 50 mg group.
Slovenian: To protivirusno delovanje se je v skupini, ki je prejemala 50 mg, ohranilo od 3 do 4 dni po zadnjem odmerku.
English: In 100% human serum, the mean fold shift for dolutegravir activity was 75 fold, resulting in protein adjusted IC90 of 0.064 µg/mL.
Slovenian: V 100% humanem serumu je bil povprečni zasuk aktivnosti dolutegravirja 75-kraten, zaradi česar je bila za protein prilagojena IC90 0,064 µg/ml.
English: If you could get pregnant while taking Dovato, you need to use a reliable method of barrier contraception (for example, a condom) with other methods of contraception including oral contraceptive (the pill) or other hormonal contraceptives (for example, implants or injections), to prevent pregnancy.
Slovenian: Če bi lahko med jemanjem zdravila Dovato zanosili, morate za preprečitev nosečnosti poleg drugih načinov kontracepcije, vključno s peroralnimi kontraceptivi (kontracepcijske tablete) ali drugimi hormonskimi kontracepcijskimi sredstvi (na primer vsadki ali injekcije), uporabljati zanesljiv način pregradne kontracepcije (na primer kondom).
English: depression, anxiety, insomnia, abnormal dreams
Slovenian: depresija, anksioznost, nespečnost, nenormalne sanje občasni:
English: Dolutegravir and lamivudine have been shown to inhibit replication of lab-strains and clinical isolates of HIV in a number of cell types, including transformed T cell lines, monocyte/macrophage derived lines and primary cultures of activated peripheral blood mononuclear cells (PMBCs) and monocyte/macrophages.
Slovenian: Dolutegravir in lamivudin dokazano zavirata replikacijo laboratorijskih sevov in kliničnih izolatov HIV v številnih vrstah celic, vključno s transformiranimi linijami celic T, linijami, pridobljenimi iz monocitov/makrofagov ter v primarnih kulturah aktiviranih mononuklearnih celic iz periferne krvi (PMBCs - peripheral blood mononuclear cells) in monocitih/makrofagih.
English: People with advanced HIV infection or AIDS have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Slovenian: Osebe z napredovalo okužbo s HIV ali AIDS imajo oslabljen imunski sistem in večjo verjetnost, da se pri njih razvije hujša okužba (oportunistične okužbe).
English: The adjusted difference was -2.6 (95% CI: -6.7; 1.5) for GEMINI-1 and0.7 (95% CI: -4.3; 2.9) for GEMINI-2 with a prespecified non-inferiority margin of 10%.
Slovenian: Prilagojena razlika je bila -2,6 (95 % IZ: -6,7, 1,5) v GEMINI-1 in -0,7 (95 % IZ: -4,3, 2,9) v GEMINI-2 s predhodno določeno mejo neinferiornosti 10 %.
English: Ledipasvir/Sofosbuvir/ Lamvudine (with abacavir)
Slovenian: ledipasvir/sofosbuvir/ lamvudin (z abacavirjem)
English: In vitro, lamivudine was an inhibitor of OCT1 and OCT2; the clinical consequences are not known.
Slovenian: In vitro je lamivudin zaviral OCT1 in OCT2; klinične posledice tega niso znane.
English: Exposure to dolutegravir was generally similar between healthy subjects and HIV-1-infected subjects.
Slovenian: Izpostavljenost dolutegravirju je bila pri zdravih osebah in osebah, okuženih z virusom HIV-1, na splošno podobna.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, biphosphonates, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported in patients with advanced HIV-disease and/or long-term exposure to CART.
Slovenian: Čeprav naj bi bila etiologija nastanka osteonekroze multifaktorska (vključujoč uporabo kortikosteroidov, difosfonatov, uživanje alkohola, hudo imunosupresijo in višji indeks telesne mase), so o primerih osteonekroze poročali predvsem pri bolnikih z napredovalo boleznijo HIV in/ali dolgotrajno izpostavljenostjo CART.
English: Dovato can be taken with or without food.
Slovenian: Zdravilo Dovato se lahko vzame s hrano ali brez nje.
English: Dolutegravir may increase plasma concentrations of medicinal products in which excretion is dependent upon OAT3.
Slovenian: Dolutegravir lahko poviša plazemske koncentracije zdravil, katerih izločanje je odvisno od OAT3.
English: creatine phosphokinase (CPK) elevations alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) elevations
Slovenian: zvišane vrednosti kreatin-fosfokinaze (CPK) zvišane vrednosti alanin-aminotransferaze (ALT) in/ali aspartat-aminotransferaze (AST)
English: • a low red blood cell count (anaemia) or low white blood cell count (neutropenia).
Slovenian: • zmanjšano število rdečih krvnih celic (anemija) ali zmanjšano število belih krvnih celic (nevtropenija).
English: These findings should be considered for any child exposed in utero to nucleoside and nucleotide analogues, who presents with severe clinical findings of unknown aetiology, particularly neurologic findings.
Slovenian: Te ugotovitve je treba upoštevati pri vseh otrocih, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom, in so se pri njih pojavile resne klinične ugotovitve neznane etiologije, še zlasti nevrološke.
English: Anti-infective products Trimethoprim/sulfamethoxazole (Co-trimoxazole)/Lamivudine (160 mg/800 mg once daily for 5 days/300 mg single dose)
Slovenian: Protimikrobna zdravila trimetoprim/sulfametoksazol (kotrimoksazol)/lamivudin (160 mg/800 mg enkrat na dan 5 dni/enkratni odmerek 300 mg)
English: There are no clinical study data on the effects of Dovato in the paediatric population.
Slovenian: Ni podatkov iz kliničnih študij o učinkih zdravila Dovato pri pediatrični populaciji.
English: → See a doctor straight away.
Slovenian: → Nemudoma obiščite zdravnika.
English: You need to know about important signs and symptoms to look out for while you're taking Dovato.
Slovenian: Pomembne znake in simptome morate poznati, da boste nanje pozorni med jemanjem zdravila Dovato.
English: Since lamivudine is dialysable, continuous haemodialysis could be used in the treatment of overdose, although this has not been studied.
Slovenian: Ker se lamivudin dializira, bi se za odpravljanje posledic zaužitja prevelikega odmerka lahko poslužili kontinuirane hemodialize, vendar pa to ni bilo raziskano.
English: Although lamivudine is a substrate of BCRP and P-gp in vitro, given its high absolute bioavailability, (see section 5.2), inhibitors of these efflux transporters are unlikely to result in a clinically relevant impact on lamivudine concentrations.
Slovenian: Čeprav je lamivudin in vitro substrat BCRP in P-gp, glede na njegovo veliko absolutno biološko uporabnost (glejte poglavje 5.2) ni verjetno, da bi zavrtje teh efluksnih prenašalcev klinično pomembno vplivalo na koncentracijo lamivudina.
English: • cladribine, to treat leukaemia or multiple sclerosis
Slovenian: • kladribin, za zdravljenje levkemije ali multiple skleroze
English: →Do not take a double dose to make up for a forgotten dose.
Slovenian: → Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: Available toxicological data in animals has shown excretion of dolutegravir in milk.
Slovenian: Razpoložljivi toksikološki podatki pri živalih so pokazali, da se dolutegravir izloča v mleko.
English: Dovato is a medicine that contains two active ingredients used to treat human immunodeficiency virus (HIV) infection: dolutegravir and lamivudine.
Slovenian: Zdravilo Dovato vsebuje dve učinkovini, ki se uporabljata za zdravljenje okužbe z virusom humane imunske pomanjkljivosti (HIV): dolutegravir in lamivudin.
English: The mean systemic clearance of lamivudine is approximately 0.32 L/h/kg, predominantly by renal clearance (> 70%) via the organic cationic transport system.
Slovenian: Srednja vrednost sistemskega očistka lamivudina je približno 0,32 l/h/kg, pri čemer glavni delež odpade na ledvični očistek (> 70%), ki poteka preko organskega kationskega transportnega sistema.
English: HIV-1 isolates (CRF01_AE, n=12; CRF02_AG, n=12; and Subtype C or CRF_AC, n=13) from 37 untreated patients in Africa and Asia were susceptible to lamivudine (IC50 fold changes < 3.0.
Slovenian: Izolati HIV-1 (CRF01_AE n = 12, CRF02_AG n = 12 in podtip C ali CRF_AC n = 13) 37 nezdravljenih bolnikov v Afriki in Aziji so bili občutljivi na lamivudin (< 3,0-kratne spremembe IC50).
English: Therefore, patients should remain under close clinical observation by physicians experienced in the treatment of these associated HIV diseases.
Slovenian: Zato morajo bolniki ostati pod skrbnim nadzorom zdravnika, ki ima izkušnje z zdravljenjem bolezni, povezanih s HIV.
English: Dolutegravir is present in the female and male genital tract.
Slovenian: Dolutegravir je prisoten v ženskem in moškem genitalnem traktu.
English: Dolutegravir had no pharmacodynamic effect on Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) and progesterone.
Slovenian: Dolutegravir ni imel farmakodinamičnega učinka na luteinizirajoči hormon (LH), folikle stimulirajoči hormon (FSH) in progesteron.
English: This combination may increase the risk for lactic acidosis in patients with moderate renal impairment (stage 3a creatinine clearance 45- 59 mL/min) and a cautious approach is recommended.
Slovenian: Ta kombinacija lahko pri bolnikih z zmerno okvaro ledvic (stadij 3a, očistek kreatinina 45-59 ml/min) poveča tveganje za laktacidozo, zato je priporočljiva previdnost.
English: Adolescents aged between 12 and 17 years and weighing at least 40 kg can take the adult dose of one tablet once a day.
Slovenian: Mladostniki, stari med 12 in 17 let, ki tehtajo vsaj 40 kg, lahko jemljejo odmerek za odrasle, to je eno tableto enkrat na dan.
English: The higher lamivudine Cmax, is not considered clinically relevant.
Slovenian: Povečanje Cmax lamivudina se ne smatra kot klinično pomembno.
English: Based on limited available data with the dolutegravir single entity or lamivudine single entity used in combination with other antiretroviral agents to treat adolescents (12 to 17 years), there were no additional types of adverse reactions beyond those observed in the adult population.
Slovenian: Na podlagi omejenih razpoložljivih podatkov o uporabi dolutegravirja ali lamivudina kot samostojne entitete v kombinaciji z drugimi protiretrovirusnimi učinkovinami za zdravljenje mladostnikov (starih od 12 do 17 let) ni bilo nobenih dodatnih neželenih učinkov poleg tistih, ki so jih zabeležili pri odraslih.
English: • hyperactivity (excessive restlessness and movement)
Slovenian: • hiperaktivnost (pretiran nemir in gibanje)
English: Oral contraceptives Ethinyl estradiol (EE) and Norgestromin (NGMN)/Dolutegravir
Slovenian: Peroralni kontraceptivi etinilestradiol (EE) in norgestromin (NGMN)/dolutegravir
English: Effect of dolutegravir and lamivudine on the pharmacokinetics of other medicinal products
Slovenian: Učinek dolutegravirja in lamivudina na farmakokinetiko drugih zdravil
English: Sulfamethoxazole: AUC ↔
Slovenian: sulfametoksazol: AUC 
English: What you need to know before you take Dovato
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Dovato
English: The efficacy of Dovato is supported by data from 2 identical 148-week, Phase III, randomised, double-blind, multicentre, parallel-group, non-inferiority controlled trials GEMINI-1 (204861) and GEMINI-2 (205543).
Slovenian: Učinkovitost zdravila Dovato potrjujejo podatki 2 identičnih, 148-tedenskih randomiziranih, dvojno slepih, multicentričnih, kontroliranih preskušanj neinferiornosti faze III z vzporednimi skupinami, GEMINI-1 (204861) in GEMINI-2 (205543).
English: Lamivudine triphosphate shows significantly less affinity for host cell DNA polymerases.
Slovenian: Lamivudin trifosfat ima občutno manjšo afiniteto do DNK polimeraz gostiteljske celice.
English: Preliminary data from a surveillance study has suggested an increased incidence of neural tube defects (0.9%) in mothers exposed to dolutegravir (a component of Dovato) at the time of conception compared with mothers exposed to non-dolutegravir containing regimens (0.1%).
Slovenian: Preliminarni podatki iz opazovalne študije so pokazali večjo incidenco okvar nevralne cevi (0,9 %) pri materah, ki so bile ob spočetju izpostavljene dolutegravirju (sestavina zdravila Dovato), v primerjavi z materami, ki so bile izpostavljene režimom, ki niso vsebovali dolutegravirja (0,1 %).
English: Lamivudine, via its active metabolite 5'-triphosphates (TP) (an analogue for cytidine), inhibits reverse transcriptase of HIV-1 and HIV-2 through incorporation of the monophosphate form into the viral DNA chain, resulting in chain termination.
Slovenian: Lamivudin preko svojih aktivnih presnovkov 5'-trifosfatov (TP) (analog citidina) zavira reverzno transkriptazo virusov HIV-1 in HIV-2 preko vključitve monofosfatne oblike v verigo virusne DNK, kar ima za posledico prekinitev verige.
English: Some late-onset neurological disorders have been reported rarely (hypertonia, convulsion, abnormal behaviour).
Slovenian: Redko so poročali o nekaterih primerih nevroloških motenj, ki nastopijo kasneje (hipertonija, konvulzije, nenormalno obnašanje).
English: Carcinogenesis and mutagenesis
Slovenian: Karcinogenost in mutagenost
English: Reduction of the metformin dose should be highly considered.
Slovenian: Potreben je temeljit razmislek o zmanjšanju odmerka metformina.
English: Dolutegravir increased metformin concentrations.
Slovenian: Dolutegravir je povečal koncentracijo metformina.
English: Dolutegravir is primarily metabolized via UGT1A1 with a minor CYP3A component (9.7% of total dose administered in a human mass balance study).
Slovenian: Dolutegravir se presnavlja predvsem preko glukoronidacije z UGT1A1 in v majhni meri s CYP3A (9,7 % skupnega odmerka, uporabljenega v študiji človeške masne bilance).
English: • sensation of weakness in the limbs.
Slovenian: • občutek šibkosti v udih