FrancophonIA/ELRC3.0 huggingface dataset:
English: If co-administration with other moderate CYP3A inducers (e.g., dabrafenib, lesinurad, bosentan, thioridazine, nafcillin, modafinil, telotristat ethyl) cannot be avoided, the doravirine dose should be increased to 100 mg twice daily (the doses should be taken approximately 12 hours apart) (see section 4.2).
Icelandic: Ef samhliða gjöf annarra meðalöflugra CYP3A virkja (t.d. dabrafenib, lesinurad, bosentan, thioridazin, nafcillin, modafinil, telotristat ethyl) er óhjákvæmileg á að auka doravirin skammtinn í 100 mg tvisvar á dag (skammtana á að taka með með u.þ.b. 12 klst. millibili) (sjá kafla 4.2).
English: Antimycobacterials
Icelandic: Lyf við mycobakteríum
English: lamivudine + tenofovir disoproxil (300 mg lamivudine SD + 245 mg tenofovir disoproxil SD, doravirine 100 mg SD)
Icelandic: lamivudin + tenofovir disoproxil (300 mg lamivudin SD + 245 mg tenofovir disoproxil SD, doravirin 100 mg SD)
English: HIV-1 RNA < 40 copies/mL 32 (80) Treatment differences (95 % CI)
Icelandic: RNA < 40 eintök/ml Meðferðarmunur (95 % CI)
English: Table 1 shows the established and other potential medicinal product interactions with doravirine but is not all inclusive (increase is indicated as , decrease is indicated as ↓, and no change as ↔).
Icelandic: Tafla 1 sýnir staðfestar milliverkanir og aðrar mögulegar milliverkanir doravirins, en taflan er ekki tæmandi (aukning er gefin til kynna sem minnkun er gefin til kynna sem ↓ og engin breyting sem
English: Doravirine 25 mg
Icelandic: Doravirin 25 mg
English: If co-administration with other moderate CYP3A inducers (e.g., dabrafenib, lesinurad, bosentan, thioridazine, nafcillin, modafinil, telotristat ethyl) cannot be avoided, one 100 mg tablet of Pifeltro should be taken twice daily (approximately 12 hours apart).
Icelandic: Ef samhliða gjöf með öðrum meðalöflugum CYP3A virkja (t.d. lesinurad, bosentan, thioridazine, nafcillin, modafinil, telotristat ethyl) er óhjákvæmileg, á að taka eina 100 Pifeltro töflu tvisvar á dag (með u.þ.b. 12 klst. millibili).
English: The tablets contain lactose monohydrate.
Icelandic: Töflurnar innihalda laktósa einhýdrat.
English: Anticonvulsants carbamazepine oxcarbazepine phenobarbital phenytoin
Icelandic: Ráðleggingar um gjöf samhliða doravirini carbamazepin oxcarbazepin phenobarbital phenytoin
English: • trouble concentrating, memory problems, tingling of hands and feet, stiff muscles, poor quality sleep
Icelandic: • einbeitingarerfiðleikar, minnistruflanir, náladofi í höndum og fótum, vöðvastífleiki, lélegur svefn
English: Doravirine should not be coadministered with medicinal products that are strong CYP3A enzyme inducers as significant decreases in doravirine plasma concentrations are expected to occur, which may decrease the effectiveness of doravirine (see sections 4.3 and 5.2).
Icelandic: Doravirin á ekki að gefa samhliða lyfjum sem eru öflugir CYP3A ensímvirkjar því gera má ráð fyrir að plasmaþéttni doravirins minnki verulega sem dregur úr áhrifum doravirins (sjá kafla 4.3 og 5.2).
English: Do not take Pifeltro:
Icelandic: Ekki má nota Pifeltro
English: Pifeltro is used to treat HIV (‘human immunodeficiency virus') infection.
Icelandic: Pifeltro er notað til meðferðar á HIV sýkingu.
English: *NRTIs in DOR arm: FTC/TDF (333) or ABC/3TC (50); NRTIs in DRV+r arm: FTC/TDF (335) or ABC/3TC (48) **Subjects received FTC/TDF
Icelandic: FTC/TDF (335) eða ABC/3TC (48) **Þátttakendur fengu FTC/TDF
English: If Pifeltro is co-administered with rifabutin, one 100 mg tablet of Pifeltro should be taken twice daily (approximately 12 hours apart) (see section 4.5).
Icelandic: Ef Pifeltro er gefið samhliða rifabutini á að taka eina 100 mg töflu af Pifeltro tvisvar á dag (með u.þ.b. 12 klst. millibili) (sjá kafla 4.5).
English: If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, talk to your doctor about the risks and benefits of taking Pifeltro.
Icelandic: Við meðgöngu, brjóstagjöf, grun um þungun eða ef þungun er fyrirhuguð á að leita ráða hjá lækninum um áhættu og ávinning af notkun Pifeltro.
English:  doravirine AUC 0.12 (0.10, 0.15) Cmax 0.43 (0.35, 0.52) C24 0.03 (0.02, 0.04) (Induction of CYP3A)
Icelandic:  doravirin AUC 0,12 (0,10; 0,15) Cmax 0,43 (0,35; 0,52) C24 0,03 (0,02; 0,04) (CYP3A virkjun)
English: • The active substance is doravirine 100 mg.
Icelandic: - Virka innihaldsefnið er doravirin 100 mg.
English: Effects of doravirine on other medicinal products
Icelandic: Áhrif doravirins á önnur lyf
English: There were no effects on fertility, mating performance or early embryonic development when doravirine was administered to rats up to 7 times the exposure in humans at the RHD.
Icelandic: Engin áhrif komu fram á frjósemi, mökun eða þroska snemma á fósturskeiði þegar doravirin var gefið rottum í skömmtum sem samsvara allt að 7 faldri útsetningu við ráðlagða skammta hjá mönnum.
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Icelandic: Læknir með reynslu af meðferð HIV-sýkinga á að hefja meðferðina.
English: There is no information on potential acute symptoms and signs of overdose with doravirine.
Icelandic: Upplýsingar um hugsanleg bráð einkenni eða teikn um ofskömmtun doravirins liggja ekki fyrir.
English: • decreased levels of phosphate
Icelandic: • minnkað magn fosfats
English: Co-administration with medicinal products that are strong cytochrome P450 CYP3A enzyme inducers is contraindicated as significant decreases in doravirine plasma concentrations are expected to occur, which may decrease the effectiveness of Pifeltro (see sections 4.4 and 4.5).
Icelandic: Má ekki gefa samhliða lyfjum sem eru öflugir cytokróm P450 CYP3A ensímvirkjar því að gert er ráð fyrir verulegri minnkun á plasmaþéttni doravirins sem getur dregið úr áhrifum Pifeltro (sjá kafla 4.4 og 4.5).
English: Pifeltro contains the active substance doravirine - a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Icelandic: Pifeltro inniheldur virka efnið doravirin - bakritahemill sem ekki er núkleósíð (NNRTI).
English: Co-administration of doravirine and medicinal products that are inhibitors of CYP3A may result in increased plasma concentrations of doravirine.
Icelandic: Samhliða gjöf doravirins og lyfja sem hamla CYP3A getur aukið plasmaþéttni doravirins.
English: Co-administration of doravirine with other moderate CYP3A inducers has not been evaluated, but decreased doravirine concentrations are expected.
Icelandic: Samhliða gjöf doravirins og annarra meðalöflugra CYP3A virkja hefur ekki verið metin, en búast má við minnkaðri doravirin þéttni.
English: Skin and subcutaneous tissue disorders Common rash
Icelandic: Húð og undirhúð Algengar útbrot
English: Expected: ↔ doravirine ↔ emtricitabine tenofovir alafenamide
Icelandic: Áætlað: ↔ doravirin ↔ emtricitabin tenofovir alafenamid
English: Baseline Regimen = ritonavir or cobicistat-boosted PI (specifically atazanavir, darunavir, or lopinavir), or cobicistat-boosted elvitegravir, or NNRTI (specifically efavirenz, nevirapine, or rilpivirine), each administered with two NRTIs.
Icelandic: Grunnmeðferð = ritonavir- eða cobicistat-örvaður próteasahemill (einkum atazanavir, darunavir eða lopinavir) eða cobicistat-örvað elvitegravir eða NNRTI (einkum efavirenz, nevirapin eða rilpivirin) hvor meðferð ásamt tveimur NRTI.
English: In the DRIVE-SHIFT trial, an immediate switch to DOR/3TC/TDF was demonstrated to be noninferior at Week 48 compared to continuation of the baseline regimen at Week 24 as assessed by the proportion of subjects with HIV-1 RNA < 40 copies/mL.
Icelandic: 48 í DRIVE-SHIFT rannsókninni var sýnt fram á að tafarlaus skipti í DOR/3TC/TDF voru ekki lakari en að halda áfram á grunnmeðferð fram að viku 24 metið með tilliti til hlutfalls þátttakenda með HIV-1 RNA < 40 eintök/ml.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with doravirine in one or more subsets of the paediatric population in treatment of human immunodeficiency virus-1 (HIV-1) infection, as per Paediatric Investigation Plan (PIP) decision in the granted indication.
Icelandic: Lyfjastofnun Evrópu hefur frestað kröfu um að lagðar séu fram niðurstöður úr rannsóknum á doravirini hjá einum eða fleiri undirhópum barna við meðferð á HIV-1 eins og lýst er í ákvörðun um
English: Rare musculoskeletal pain
Icelandic: Sjaldgæfar vöðvaverkir, liðverkir
English: No dose adjustment of doravirine is needed in elderly patients (see section 5.2).
Icelandic: Aldraðir Ekki þarf að aðlaga skammta doravirins hjá öldruðum sjúklingum (sjá kafla 5.2).
English: How to store Pifeltro
Icelandic: Hvernig geyma á Pifeltro
English:  doravirine AUC 1.15 (1.07, 1.24) Cmax 1.11 (0.97, 1.27) C24 1.24 (1.13, 1.36)
Icelandic:  doravirin AUC 1,15 (1,07; 1,24) Cmax 1,11 (0,97; 1,27) C24 1,24 (1,13; 1,36)
English: • The bottle contains a desiccant protecting the tablets from moisture.
Icelandic: - Í glasinu er þurrkefni sem ver töflurnar gegn raka.
English: Although a limited number of subjects aged 65 years and over has been included (n=36), no clinically relevant differences in the pharmacokinetics of doravirine have been identified in subjects at least 65 years of age compared to subjects less than 65 years of age in a Phase 1 trial or in a population pharmacokinetic analysis.
Icelandic: Þótt takmarkaður fjöldi einstaklinga 65 ára og eldri hafi tekið þátt (N=36) er enginn klínískt marktækur munur á lyfjahvörfum doravirins hjá þeim sem eru a.m.k.
English: Expected:  doravirine (CYP3A inhibition) ↔ elvitegravir
Icelandic: Áætlað:  doravirin (CYP3A hömlun) ↔ elvitegravir
English: Therefore, caution is advised when doravirine is administered to patients with severe hepatic impairment (see section 5.2).
Icelandic: Því er ráðlagt að gæta varúðar við gjöf doravirins hjá sjúklingum með verulega skerta lifrarstarfsemi (sjá kafla 5.2).
English: No clinically relevant pharmacokinetic differences have been identified between men and women for doravirine.
Icelandic: Enginn klínískt marktækur munur er á lyfjahvörfum doravirins hjá körlum og konum.
English:  doravirine AUC 3.54 (3.04, 4.11) Cmax 1.31 (1.17, 1.46) C24 2.91 (2.33, 3.62) (Inhibition of CYP3A)
Icelandic:  doravirin AUC 3,54 (3,04; 4,11) Cmax 1,31 (1,17; 1,46) C24 2,91 (2,33; 3,62) (CYP3A hömlun)
English: Expected: ↔ doravirine ↔ maraviroc
Icelandic: Áætlað: ↔ doravirin ↔ maraviroc
English: Kinase Inhibitors dabrafenib
Icelandic: Kínasahemlar dabrafenib
English: •bosentan (a medicine to treat lung disease) •dabrafenib (a medicine to treat skin cancer)
Icelandic: • dabrafenib (lyf við húðkrabbameini)
English: Rare dermatitis allergic, rosacea
Icelandic: Mjög sjaldgæfar ofnæmishúðbólga, rósroði
English:  doravirine AUC 3.06 (2.85, 3.29) Cmax 1.25 (1.05, 1.49) C24 2.75 (2.54, 2.98) (Inhibition of CYP3A)
Icelandic:  doravirin AUC 3,06 (2,85; 3,29) Cmax 1,25 (1,05; 1,49) C24 2,75 (2,54; 2,98) (CYP3A hömlun)
English: Doravirine 200 mg
Icelandic: Doravirin 200 mg
English: Doravirine 100 mg
Icelandic: Doravirin 100 mg
English:  ethinyl oestradiol AUC 0.98 (0.94, 1.03) Cmax 0.83 (0.80, 0.87)
Icelandic:  ethinyl estradiol AUC 0,98 (0,94; 1,03) Cmax 0,83 (0,80; 0,87)
English: Expected: ↔ doravirine ↔ raltegravir ritonavir †-boosted elvitegravir
Icelandic: Áætlað: ↔ doravirin ↔ raltegravir ritonavir
English:  doravirine AUC 0.50 (0.45, 0.55) Cmax 0.99 (0.85, 1.15) C24 0.32 (0.28, 0.35) (Induction of CYP3A)
Icelandic:  doravirin AUC 0,50 (0,45; 0,55) Cmax 0,99 (0,85; 1,15) C24 0,32 (0,28; 0,35) (CYP3A virkjun)
English: Successful genotype, n Genotypic resistance to DOR or control (DRV or EFV) 2 (DOR)
Icelandic: DOR eða viðmið (DRV eða EFV)
English: When doravirine is co-administered with rifabutin, the doravirine dose should be increased to 100 mg twice daily (the doses should be taken approximately 12 hours apart) (see section 4.2).
Icelandic: Þegar doravirin er gefið ásamt rifabutini á að auka doravirin skammtinn í 100 mg tvisvar á dag (skammtana á að taka með með u.þ.b. 12 klst. millibili) (sjá kafla 4.2).
English: Uncommon lipase increased, aspartate aminotransferase increased, amylase increased, haemoglobin decreased
Icelandic: Sjaldgæfar aukinn lípasi, aukinn aspartat aminótransferasi, aukinn amýlasi, minnkað hemóglóbín
English: The pharmacokinetics of doravirine were studied in healthy subjects and HIV-1 infected subjects.
Icelandic: Lyfjahvörf doravirins voru rannsökuð hjá heilbrigðum þátttakendum og einstaklingum sýktum með HIV-1.
English: In a population pharmacokinetic analysis, which included subjects with CrCl between 17 and 317 mL/min, renal function did not have a clinically relevant effect on doravirine pharmacokinetics.
Icelandic: Í þýðisgreiningu á lyfjahvörfum sem tók til einstaklinga með kreatínínúthreinsun (CrCl) á bilinu 17 og 317 ml/mín.
English:  dolutegravir AUC 1.36 (1.15, 1.62) Cmax 1.43 (1.20, 1.71) C24 1.27 (1.06, 1.53) (Inhibition of BCRP)
Icelandic:  dolutegravir AUC 1,36 (1,15; 1,62) Cmax 1,43 (1,20; 1,71) C24 1,27 (1,06; 1,53) (BCRP virkjun)
English: If doravirine is co-administered with rifabutin, the doravirine dose should be increased to 100 mg twice daily (approximately 12 hours apart).
Icelandic: Ef doravirin er gefið samhliða rifabutini á að auka doravirin skammtinn í 100 mg tvisvar á dag (með u.þ.b. 12 klst. millibili)
English: DRV + r + NRTIs*
Icelandic: DRV + r
English: Warnings and precautions Talk to your doctor, pharmacist, or nurse before taking Pifeltro.
Icelandic: Leitið ráða hjá lækninum, lyfjafræðingi eða hjúkrunarfræðingnum áður en Pifeltro er notað.
English: • 90 film-coated tablets (3 bottles of 30 film-coated tablets).
Icelandic: 90 filmuhúðaðar töflur (3 glös með 30 filmuhúðuðum töflum).
English: Other medicines and Pifeltro
Icelandic: Notkun annarra lyfja samhliða Pifeltro
English: Biotransformation Based on in vitro data, doravirine is primarily metabolized by CYP3A.
Icelandic: Samkvæmt in vitro upplýsingum umbrotnar doravirin aðallega fyrir tilstilli CYP3A.
English: Expected: ↔ doravirine ↔ tenofovir alafenamide
Icelandic: Áætlað: ↔ doravirin ↔ tenofovir alafenamid
English:  doravirine AUC 1.56 (1.45, 1.68) Cmax 1.41 (1.25, 1.58) C24 1.61 (1.45, 1.79) (Inhibition of CYP3A)
Icelandic:  doravirin AUC 1,56 (1,45; 1,68) Cmax 1,41 (1,25; 1,58) C24 1,61 (1,45; 1,79) (CYP3A hömlun)
English: Expected: ↔ doravirine ↔ abacavir
Icelandic: Áætlað: ↔ doravirin ↔ abacavir emtricitabin
English: Table 2: Tabulated summary of adverse reactions associated with doravirine used in combination with other antiretrovirals
Icelandic: Tafla með aukaverkunum sem tengjast doravirini við notkun ásamt öðrum andretróveirulyfjum
English: No clinically relevant racial differences in the pharmacokinetics of doravirine have been identified based on a population pharmacokinetic analysis of doravirine in healthy and HIV-1 infected subjects.
Icelandic: Enginn klínískt marktækur munur er á lyfjahvörfum doravirins m.t.t. kynþáttar samkvæmt þýðisgreiningu á lyfjahvörfum doravirins hjá heilbrigðum og þeim sem eru sýktir með HIV-1.
English: At baseline, the median age of subjects was 31 years (range 18-70 years), 85 % were male, 52 % were non-white, 3% had hepatitis B or C co-infection, 14 % had a history of AIDS, 21 % had HIV-1 RNA > 100,000 copies per mL, and 12 % had CD4
Icelandic: Við upphaf var miðgildi aldurs 31 ár (á bilinu 18-70 ár), 85 % voru karlar, 52% voru ekki hvítir, 3% voru einnig með lifrarbólgu
English: • The other ingredients are croscarmellose sodium E468; hypromellose acetate succinate; lactose monohydrate; magnesium stearate E470b; microcrystalline cellulose E460; and silica, colloidal anhydrous E551.
Icelandic: - Önnur innihaldsefni eru croscarmellósi natríum E468, hypromellósi acetat succinat, laktósa einhýdrat, magnesium stearat E470b, örkristallaður cellulósi E460 og vatnsfrí kísilkvoða E551, Töflurnar eru filmuhúðaðar, húðin inniheldur eftirfarandi efni: karnabauvax E903, hypromellósa E464, laktósa einhýdrat, titandioxíð E171 og triacetin E1518.
English: Expected:  doravirine (Inhibition of CYP3A due to ritonavir)
Icelandic: Áætlað:  doravirin (CYP3A hömlun vegna ritonavirs)
English: Doravirine has not been studied in patients with end-stage renal disease and has not been studied in dialysis patients (see section 5.2).
Icelandic: Doravirin hefur hvorki verið rannsakað hjá sjúklingum með nýrnasjúkdóm á lokastigi né sjúklingum í himnuskilun (sjá kafla 5.2).
English: Pifeltro tablets contain lactose
Icelandic: Pifeltro inniheldur laktósa
English: After week 24, all subjects randomized to receive doravirine were switched to (or maintained on) doravirine 100 mg. Additional subjects were randomized in Part II to receive either doravirine 100 mg or EFV, each in combination with FTC/TDF.
Icelandic: 24 var öllum þátttakendum slembiraðað og fengu doravirin og var skipt yfir í (eða héldu áfram á) doravirin 100 mg.
English: How to take Pifeltro
Icelandic: Hvernig nota á Pifeltro
English: Expected: ↔ doravirine ombitasvir/ paritaprevir/ritonavir and dasabuvir+/-ritonavir
Icelandic: Ráðleggingar um gjöf samhliða doravirini ombitasvir/paritaprevir/ritonavir og dasabuvir+/-ritonavir
English: The following de novo resistance was seen in the resistance analysis subset (subjects with HIV-1 RNA greater than 400 copies per mL at virologic failure or early study discontinuation and having resistance data).
Icelandic: Eftirfarandi nýtilkomið ónæmi sást hjá undirhóp við ónæmisgreiningu (þeir sem voru með yfir 400 eintök/ml HIV-1
English: If you stop taking Pifeltro Do not run out of this medicine.
Icelandic: Ekki verða uppiskroppa með þetta lyf.
English: Ritonavir- or Cobicistat-boosted PI
Icelandic: Ritonavir- eða cobicistat-örvaður próteasahemill
English: Tel: +386 1 5204 201 msd.slovenia@merck.com
Icelandic: +386 1 5204 201 msd.slovenia@merck.com medinfo_ireland@merck.com
English: Antiandrogens enzalutamide
Icelandic: And-androgen lyf s enzalutamid
English: No dose adjustment is required in patients with mild, moderate or severe renal impairment.
Icelandic: Ekki þarf að aðlaga skammta doravirins hjá sjúklingum með vægt skerta, meðalskerta eða verulega skerta nýrnastarfsemi.
English: See package leaflet for further information
Icelandic: Inniheldur laktósa Sjá fylgiseðil fyrir frekari upplýsingar
English: If a patient misses a dose by more than 12 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time.
Icelandic: Ef sjúklingur gleymir skammti lengur en í 12 klst.
English: Doravirine steady state pharmacokinetics following administration of 100 mg once daily to HIV-1 infected subjects, based on a population pharmacokinetics analysis, are provided below.
Icelandic: Lyfjahvörf doravirins við jafnvægi hjá einstaklingum sýktum með HIV-1 eftir gjöf 100 mg einu sinni á dag byggt á þýðisgreiningu á lyfjahvörfum eru sýnd hér á eftir.
English:  lamivudine AUC 0.94 (0.88, 1.00) Cmax 0.92 (0.81, 1.05)
Icelandic:  lamivudin AUC 0,94 (0,88; 1,00) Cmax 0,92 (0,81; 1,05)
English: • feeling weak, general feeling of being unwell
Icelandic: • slappleiki, almenn vanlíðan
English: This is because it has not been studied in pregnancy and it is not known if it will harm your baby while you are pregnant.
Icelandic: Helst á að forðast notkun lyfsins á meðgöngu vegna þess að það hefur ekki verið rannsakað á meðgöngu og ekki er vitað hvort það hafi skaðleg áhrif á fóstur.
English:  doravirine AUC 1.00 (0.89, 1.12) Cmax 1.06 (0.88, 1.28) C24 0.98 (0.88, 1.09)
Icelandic:  doravirin AUC 1,00 (0,89; 1,12) Cmax 1,06 (0,88; 1,28) C24 0,98 (0,88; 1,09)
English: Pharmacokinetic Enhancers ritonavir (100 mg BID, doravirine 50 mg SD)
Icelandic: Lyfjhvarfaörvar ritonavir (100 mg BID, doravirin 50 mg SD)
English:  doravirine AUC 0.74 (0.61, 0.90) Cmax 0.76 (0.63, 0.91) C24 0.80 (0.63, 1.03)
Icelandic:  doravirin AUC 0,74 (0,61; 0,90) Cmax 0,76 (0,63; 0,91) C24 0,80 (0,63; 1,03)
English: If co-administration cannot be avoided, one tablet of doravirine should be taken twice daily (approximately 12 hours apart).
Icelandic: Ef samhliða gjöf er óhjákvæmileg á að taka eina töflu af doravirini tvisvar á dag ( með u.þ.b. 12 klst. millibili).
English: Rare hypomagnesaemia
Icelandic: Mjög sjaldgæfar blóðmagnesíumlækkun
English:  doravirine AUC 0.83 (0.76, 0.91) Cmax 0.88 (0.76, 1.01) C24 0.84 (0.77, 0.92)
Icelandic:  doravirin AUC 0,83 (0,76; 0,91) Cmax 0,88 (0,76; 1,01) C24 0,84 (0,77; 0,92)
English: Single dose rifampicin (600 mg SD, doravirine 100 mg SD)
Icelandic: Stakur skammtur rifampicin (600 mg SD, doravirin 100 mg SD)
English: • It is important that you do not miss or skip doses of this medicine.
Icelandic: Mikilvægt er að sleppa ekki úr skammti af þessu lyfi
English: HIV Antiviral Agents Fusion and Entry Inhibitors enfuvirtide
Icelandic: HIV veirulyf Samruna-og inngönguhemlar (CCR5 hemlar)
English: Table 1: Interactions of doravirine with other medicinal products
Icelandic: Milliverkanir doravirins og annarra lyfja
English: DOR + 2 NRTIs
Icelandic: 2 NRTIs
English: Tel: +353 (0)1 2998700 medinfo_ireland@merck.com
Icelandic: Tel: +353 (0)1 2998700
English: • increased levels of liver enzymes (AST)
Icelandic: • aukið magn lifrarensíma (ASAT)
English: ↔ boosted PIs cobicistat-boosted PIs (darunavir, atazanavir)
Icelandic: ↔ örvaðir próteasahemlar cobicistat-örvaðir próteasahemlar (darunavir, atazanavir)
English: ↔ boosted PIs
Icelandic: Skert nýrnastarfsemi
English: rifapentine
Icelandic: Brjóstagjöf
English: indigestion, soft stools, stomach spasms
Icelandic: höfuðverkur, sundl, syfja
English: Expected: ↔ canagliflozin ↔ liraglutide ↔ sitagliptin
Icelandic: Áætlað: ↔ canagliflozin ↔ liraglutid ↔ sitagliptin
English: Multiple dose rifampicin (600 mg QD, doravirine 100 mg SD)
Icelandic: Endurteknir skammtar af rifampicini (600 mg QD, doravirin 100 mg SD)
English: • headache, dizziness, sleepiness
Icelandic: Algengar höfuðverkur, sundl, svefnhöfgi
English: Integrase Strand Transfer Inhibitors dolutegravir (50 mg QD, doravirine 200 mg QD)
Icelandic: dolutegravir (50 mg QD, doravirin 200 mg QD)
English: Nucleoside Reverse Transcriptase Inhibitors tenofovir disoproxil (245 mg QD, doravirine 100 mg SD)
Icelandic: tenofovir disoproxil (245 mg QD, doravirin 100 mg SD)
English: Doravirine 50 mg
Icelandic: 50 mg
English: What Pifeltro is
Icelandic: Pifeltro inniheldur
English: Expected:  doravirine (CYP3A inhibition)
Icelandic: Áætlað:  doravirin (CYP3A hömlun)
English: Antineoplastics mitotane
Icelandic: Geðrofslyf thioridazin
English: Respiratory, thoracic and mediastinal disorders Rare dyspnoea, tonsillar hypertrophy
Icelandic: Öndunarfæri, brjósthol og miðmæti Mjög sjaldgæfar mæði, stækkaðir hálskirtlar
English: Expected: ↓ doravirine (Induction of CYP3A)
Icelandic: Áætlað: ↓ doravirin (CYP3A virkjun)
English: Recommendation Concerning Co-administration with doravirine emtricitabine
Icelandic: Ráðleggingar um gjöf samhliða doravirini
English: Expected:  doravirine daclatasvir
Icelandic: Áætlað:  doravirin daclatasvir
English: Doravirine is primarily metabolized and eliminated by the liver.
Icelandic: Umbrot og brotthvarf doravirins er aðallega í lifur.
English: Mean CD4 change from baseline (cells/mm
Icelandic: Meðal CD4 breyting frá upphafsgildi (frumur/mm jákvætt gildi doravirini í hag miðað við efavirenz.
English: Renal and urinary disorders Rare acute kidney injury, renal disorder, calculus urinary, nephrolithiasis General disorders and administration site conditions Common fatigue
Icelandic: Mjög sjaldgæfar bráður nýrnaskaði, nýrnaraskanir, þvagfærasteinn, nýrnasteinakvilli Almennar aukaverkanir og aukaverkanir á íkomustað Algengar þreyta
English: NRTI background therapy
Icelandic: Krampaleysandi lyf
English: Co-administration should be avoided.
Icelandic: Forðast á samhliða gjöf.
English: Uncommon nightmare, depression 2, anxiety 3, irritability, confusional state, suicidal ideation
Icelandic: 3, skapstyggð, ringlunarástand, sjálfsvígshugleiðingar
English: Swallow whole.
Icelandic: Til inntöku, gleypist í heilu lagi
English: België/Belgique/Belgien MSD Belgium BVBA/SPRL Tél/Tel: +32(0)27766211 dpoc_belux@merck.com
Icelandic: België/Belgique/Belgien MSD Belgium BVBA/SPRL Tél/Tel:
English: 50 to < 65
Icelandic: 50 til < 65
English: You can take Talzenna with food or between meals.
Icelandic: Taka má Talzenna með mat eða milli máltíða.
English: Talzenna with food and drink
Icelandic: Talzenna með mat og drykk