FrancophonIA/ELRC3.0 huggingface dataset:
English: Increases in cholesterol and triglyceride levels may be associated with thiazide diuretic therapy.
Danish: Stigning i kolesterol- og triglyceridkoncentration kan være associeret med behandling med thiazider.
English: Uncommon (affecting less than one person in 100 but more than one person in 1,000):
Danish: Ikke almindelige (berører færre end én person ud af 100 men flere end én person ud af 1.000):
English: HDPE bottles of 100 tablets.
Danish: HDPE-beholder à 100 tabletter.
English: Cholestyramine and colestipol resins:
Danish: Cholestyramin og colestipolresiner
English: As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
Danish: Som ved andre stoffer, der blokerer angiotensin-II eller dets virkning, kan samtidig brug af kaliumbesparende diuretika (f.eks. spironolacton, triamteren, amilorid), kaliumtilskud eller kaliumholdige salterstatninger medføre stigninger i serumkalium.
English: In some patients with compromised renal function who are being treated with non-steroidal antiinflammatory drugs, including selective cyclooxygenase-2 inhibitors, the co-administration of angiotensin II receptor antagonists may result in a further deterioration of renal function.
Danish: Hos nogle patienter med kompromitteret nyrefunktion, og som bliver behandlet med NSAID, herunder selektive COX-2-hæmmere, kan samtidig administration angiotensin II-receptorantagonister resultere i en yderligere forværring af nyrefunktionen.
English: Because of their effects on calcium metabolism, thiazides may interfere with tests for parathyroid function (see section 4.4).
Danish: På grund af deres virkning på calciummetabolismen, kan thiazider interferere med parathyreoideaprøver (se pkt.
English: Quinte da Fonte Edificio Vasco da Gama, 19 P.O.
Danish: Edificio Vasco da Gama, 19 P.O. BOX 214
English: The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.
Danish: Det er ikke fastlagt i hvor høj grad, hydrochlorthiazid kan fjernes ved hæmodialyse.
English: Thiazides may decrease urinary calcium excretion and may cause intermittent and slight elevation of serum calcium.
Danish: Thiazider kan nedsætte calciumudskillelsen i urinen og kan forårsage periodisk og let forhøjelse af serumcalcium.
English: • Inflammation of blood vessels, which is often associated with a skin rash or bruising,
Danish: • Betændelse i blodkar, som ofte er forbundet med hududslæt eller blå mærker
English: • if you have narrow arteries to your kidneys (renal artery stenosis) or only have one functioning kidney, or you have recently had a kidney transplant
Danish: • hvis De har forsnævring af de blodkar, der fører til nyrerne (nyreateriestenose), eller hvis De kun har en fungerende nyre, eller de for nylig har fået nyretransplantation,
English: Despite the significant decrease in blood pressure, administration of Cozaar Comp had no clinically significant effect on heart rate.
Danish: På trods af klinisk signifikant blodtryksfald havde administration af Cozaar Comp. ingen klinisk signifikant virkning på hjertefrekvensen.
English: Always take Cozaar Comp exactly as your doctor has instructed you.
Danish: Tag altid Cozaar Comp. nøjagtigt efter lægens anvisning.
English: Hydrochlorothiazide may reduce both plasma volume and uteroplacental blood flow.
Danish: Hydrochlorthiazid kan reducere både plasmavolumen og blodgennemstrømningen i livmoder/placenta.
English: Unless continued Losartan/HTCZ therapy is considered essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy.
Danish: Med mindre fortsat behandling med losartan/hydrochlorthiazid anses for essentiel, bør patienter, der planlægger graviditet, skiftes til alternativ antihypertensiv behandling, som har en etableret sikkerhedsprofil for anvendelse under graviditet.
English: Uncommon: Necrotizing angiitis (vasculitis, cutaneous vasculitis)
Danish: Vaskulære sygdomme Ikke almindelig: Nekrotiserende angitis (vasculitis, kutan vasculitis).
English: Patients should be observed for clinical signs of fluid or electrolyte imbalance, e.g., volume depletion, hyponatremia, hypochloremic alkalosis, hypomagnesemia or hypokalemia which may occur during intercurrent diarrhea or vomiting.
Danish: Patienterne bør observeres for kliniske tegn på væske- eller elektrolytforstyrrelser, f.eks. væskemangel, hyponatriæmi, hypochloræmisk alkalose, hypomagnesiæmi eller hypokaliæmi, som kan forekomme ved tilstødende diarré eller opkastning.
English: The MAH did not provide data showing that those patients receiving HCTZ had a clinical advantage with respect to clinical endpoints in comparison to those not receiving HCTZ.
Danish: Indehaveren af markedsføringstilladelsen fremlagde ingen data, der viste, at de patienter, der fik hydrochlorthiazid, havde en klinisk fordel med hensyn til de kliniske slutmål sammenlignet med de patienter, der ikke fik hydrochlorthiazid.
English: The occurrence of hypotension was dose related in these heart failure patients.
Danish: Forekomst af hypotension var dosisrelateret hos patienter med ovennævnte type af hjertesvigt.
English: Heart failure:
Danish: Hjerteinsufficiens
English: The adverse events were restricted to those which were formerly observed with losartan potassium salt and/or hydrochlorothiazide.
Danish: Bivirkningerne var begrænset til dem, som tidligere er rapporteret ved behandling med losartankalium og/eller hydrochlorthiazid.
English: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Danish: Absorptionen af hydrochlorthiazid er nedsat i forbindelse med anionbytterresiner.
English: Administration of losartan blocks all the physiologically relevant actions of angiotensin II and through inhibition of aldosterone could tend to attenuate the potassium loss associated with the diuretic.
Danish: Administration af losartan blokerer alle fysiologisk relevante virkninger af angiotensin-II, og ved hæmning af aldosteron kan dette måske forstærke det tab af kalium, som er associeret med diuretika.
English: - The scope of the referral was the harmonisation of the Summaries of Products Characteristics, labelling and package leaflet.
Danish: - Formålet med indbringelsen af sagen var harmonisering af produktresuméer, etikettering og indlægsseddel.
English: The active substances are losartan potassium and hydrochlorothiazide.
Danish: De aktive indholdsstoffer er losartankalium og hydrochlorthiazid.
English: • Blurred vision, burning or stinging in the eyes, conjunctivitis, worsening eyesight, seeing things in yellow,
Danish: • Sløret syn, brænden eller stikken i øjnene, betændelse i øjets bindehinde, forværring af synet, se ting i gult
English: Pregnancy and Lactation should be contraindicated and the appropriate wording included in sections 4.3, 4.4 and 4.6 of the SPC, and the relevant sections of the Package Leaflet.
Danish: Graviditet og amning skal kontraindiceres, og den relevante ordlyd skal inkluderes i afsnit 4.3, 4.4 og 4.6 i produktresuméet samt i de relevante afsnit af indlægssedlen.
English: In nondiabetic hypertensive patients with proteinuria, the administration of losartan potassium significantly reduces proteinuria, fractional excretion of albumin and IgG.
Danish: Hos ikke-diabetiske, hypertensive patienter med proteinuri gav administration af losartankalium signifikant reduktion i proteinuri, fraktioneret ekskretion af albumin og IgG.
English: • Reduction of cardiovascular morbidity and mortality (or risk of stroke) in hypertensive patients with left ventricular hypertrophy.
Danish: • Reduktion af kardiovaskulær morbiditet og mortalitet (eller risiko for slagtilfælde) hos hypertensive patienter med venstresidig ventrikelhypertrofi.
English: Dietary salt in excessive quantities may counteract the effect of Cozaar Comp tablets.
Danish: Diætsalt i store mængder kan modvirke virkningen af Cozaar Comp.
English: • Class Ia antiarrythmics (eg quinidine, hydroquinidine, disopyramide).
Danish: Klasse Ia antiarytmika (f.eks. quinidin, hydroquinidin, disopyramid).
English: Skin and subcutaneous tissue disorders Uncommon: Photosensitivity, urticaria, toxic epidermal necrolysis
Danish: Hud og subkutane væv Ikke almindelig: Fotosensitivitet, urticaria, toksisk epidermal nekrolyse.
English: The usual dose of Cozaar Comp for most patients with high blood pressure is 1 tablet of Cozaar Comp 50 mg/12.5 mg per day to control blood pressure over the 24-hour period.
Danish: Den normale dosis Cozaar Comp. til de fleste patienter med forhøjet blodtryk er 1 tablet Cozaar Comp. 50 mg/12,5 mg daligt til kontrol af blodtrykket over en 24-timers periode.
English: Special precautionary measures (e.g. blood tests) may be appropriate if you take potassium supplements, potassium-containing salt substitutes or potassium-sparing medicines, other diuretics (“water tablets”), some laxatives, medicines for the treatment of gout, medicines to control heart rhythm or for diabetes (oral agents or insulins).
Danish: Særlige forholdsregler (f.eks. blodprøver) kan være hensigtsmæssige, hvis De tager kaliumtilskud, salterstatninger med kalium eller kaliumbesparende medicin, anden vanddrivende medicin, visse afføringsmidler, medicin til behandling af urinsur gigt, medicin til at kontrollere hjerterytmen eller diabetesmedicin (medicin til at tage gennem munden eller insulin).
English: • Loss of appetite, increased uric acid levels or frank gout, increased blood sugar levels, abnormal blood electrolyte levels,
Danish: • Manglende appetit, øget koncentration af urinsyre eller regulær urinsur gigt, øget blodsukker, unormal koncentration af elektrolytter i blodet
English: Yellow, oval film-coated tablets marked 717 on one side and plain or scored on the other.
Danish: Gule, ovale, filmovertrukne tabletter mærket 717 på den ene side og glatte eller med delekærv på den anden side.
English: Respiratory, thoracic and mediastinal disorders Uncommon: Respiratory distress including pneumonitis and pulmonary oedema
Danish: Luftveje, thorax og mediastinum Ikke almindelig: Respirationsbesvær, herunder pneumonitis og lungeødem.
English: Thiazide-induced hypokalaemia or hypomagnesaemia may favour the onset of digitalis-induced cardiac arrhythmias.
Danish: Thiazidinduceret hypokaliæmi eller hypomagnesiæmi kan fremme forekomst af digitalisinduceret hjertearytmi.
English: Because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates the diureticinduced hyperuricemia.
Danish: Da losartan nedsætter urinsyremængden, dæmper losartan i kombination med hydrochlorthiazid den diuretikainducerede hyperurikæmi.
English: • 2nd and 3rd trimester of pregnancy (see section 4.4 and 4.6)
Danish: 2. og 3. trimester af graviditeten (se pkt.
English: The treatment with a thiazide may influence the glucose tolerance.
Danish: Behandling med thiazid kan påvirke glucosetolerancen.
English: Cozaar Comp works equally well in and is equally well tolerated by most older and younger adult patients.
Danish: Cozaar Comp. virker lige godt hos de fleste ældre og yngre personer, og de fleste ældre som yngre personer tåler det lige godt.
English: - As First step treatment in patients with moderate to severe hypertension and in patients with high or very high Left Ventricular Hypertrophy
Danish: - Som førstevalgsbehandling af patienter med moderat til svær hypertension og af patienter med svær eller meget svær venstresidig ventrikelhypertrofi
English: The toxic potential of the combination of losartan/hydrochlorothiazide was evaluated in chronic toxicity studies for up to six months duration in rats and dogs after oral administration, and the changes observed in these studies with the combination were mainly produced by the losartan component.
Danish: Losartan/hydrochlorthiazids toksiske potential blev vurderet i gentagne toksicitetsundersøgelser af op til 6 måneders varighed hos rotter og hunde efter oral administration.
English: Uncommon: Hypotension, orthostatic hypotension, sternalgia, angina pectoris, grade II-AV block, cerebrovascular event, myocardial infarction, palpitation, arrhythmias (atrial fibrillations, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation)
Danish: Ikke almindelig: Hypotension, orthostatisk hypotension, sternalgi, angina pectoris, AV-blok af 2. grad, cerebrovaskulær hændelse, myokardieinfarkt, palpitation, arytmi (atrieflimren, sinusbradykardi, takykardi, ventrikulær takykardi, ventrikelflimren).
English: Thiazide therapy may precipitate hyperuricemia and/or gout in certain patients.
Danish: Thiazidbehandling kan fremskynde hyperurikæmi og/eller arthritis urica hos nogle patienter.
English: In clinical trials, after 12 weeks of therapy with losartan 50 mg/hydrochlorothiazide 12.5 mg, trough sitting diastolic blood pressure was reduced by an average of up to 13.2 mmHg.
Danish: Efter 12 ugers behandling i kliniske undersøgelser med losartan 50 mg/hydrochlorthiazid 12,5 mg, blev lavest målte, siddende diastole blodtryk reduceret med gennemsnitligt 13,2 mmHg.
English: Uncommon: Nervousness, paraesthesia, peripheral neuropathy, tremor, migraine, syncope
Danish: Ikke almindelig: Nervøsitet, paræstesi, perifer neuropati, tremor, migræne, synkope.
English: Digitalis glycosides
Danish: Digitalisglycosider
English: • Severe hepatic impairment; Cholestasis and biliary obstructive disorders
Danish: Svær leverinsufficiens; cholestasis og biliære obstruktionsforstyrrelser.
English: In controlled clinical trials for essential hypertension, dizziness was the only adverse experience reported as substance-related that occurred with an incidence greater than placebo in 1% or more of patients treated with losartan and hydrochlorothiazide.
Danish: I kontrollerede kliniske undersøgelser med henblik på hypertension var svimmelhed den eneste hændelse, der blev rapporteret som lægemiddelrelateret, og som forekom med en incidens, der var hyppigere end for placebo hos ≥ 1% af de patienter, der blev behandlet med losartan og hydrochlorthiazid.
English: Store Cozaar Comp in the original package.
Danish: Opbevar Cozaar Comp. i den originale yderpakning.
English: Diuretic agents such as the hydrochlorothiazide contained in Cozaar Comp may interact with other medicines.
Danish: Vanddrivende lægemidler, såsom hydrochlorthiazid der er i Cozaar Comp., kan påvirke anden medicin, ligesom anden medicin kan påvirke de vanddrivende lægemidler.
English: Cozaar Comp therapy exposure during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see also 5.3 'Preclinical safety data').
Danish: Eksponering for Cozaar Comp. i 2. og 3. trimester inducerer føtotoksicitet hos mennesker (nedsat nyrefunktion, oligohydramnios, forsinket kranieossifikation) og neonatal toksicitet (nyresvigt, hypotension, hyperkaliæmi) (se også pkt.
English: • Anaemia, red or brownish spots on the skin (sometimes especially on the feet, legs, arms and buttocks, with joint pain, swelling of the hands and feet and stomach pain), bruising, reduction in white blood cells, clotting problems and bruising,
Danish: • Blodmangel, røde eller brunlige pletter på huden (af og til især på fødder, ben, arme og balder, med ledsmerter, hævede hænder og fødder samt mavesmerter), blå mærker, nedsat antal hvide blodlegemer, blodstørkningsproblemer og blå mærker
English: Losartan should be used with caution in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.
Danish: Losartan bør anvendes med forsigtighed hos patienter med bilateral nyrearteriestenose eller unilateral nyrearterie stenose (hvis funktionelt ennyret).
English: • Pain in the arms, shoulders, hips, knees or other joints, joint swelling, stiffness, muscle weakness,
Danish: • Smerter i arme, skuldre, hofter, knæ eller andre led, ledhævelse, stivhed, muskelsvaghed
English: • Sore throat, breathlessness, bronchitis, pneumonia, water on the lungs (which causes difficulty breathing), nosebleed, runny nose, congestion,
Danish: • Ømhed i halsen, kortåndethed, bronkitis, lungebetændelse, vand i lungerne (som medfører besvær med at trække vejret), næseblod, løbende næse, tilstopning
English: • Therapy resistant hypokalaemia or hypercalcaemia
Danish: Behandlingsresistent hypokaliæmi eller hyperkalcæmi.
English: SPECIAL STORAGE CONDITIONS Store in the original bottle.
Danish: SÆRLIGE OPBEVARINGSBETINGELSER Opbevares i den originale beholder.
English: • Some antipsychotics (eg thioridazine, chlorpromazine, levomepromazine, trifluoperazine, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol).
Danish: Nogle antipsykotika (f.eks. thioridazin, chlorpromazin, levomepromazin, trifluperazin, cyamemazin, sulpirid, sultoprid, amisulprid, tiaprid, pimozid, haloperidol, droperidol).
English: Cozaar Comp tablets may be taken with or without food.
Danish: De kan tage Cozaar Comp. med eller uden mad.
English: • Ringing, buzzing, roaring or clicking in the ears,
Danish: • Ringen, summen, brølen eller klikken i ørerne
English: Nervous system disorders Common: Cephalalgia
Danish: Nervesystemet Almindelig: Cefalalgi.
English: Hypotension and electrolyte/fluid imbalance
Danish: Hypotension og elektrolyt-/væskeforstyrrelser
English: Hepato-biliary disorders Rare: Hepatitis
Danish: Lever og galdeveje Sjælden: Hepatitis.
English: Anticholinergic agents (e.g. atropine, biperiden)
Danish: Antikolinerge lægemidler (f.eks. atropin, biperiden)
English: Vascular disorders Uncommon: Vasculitis
Danish: Vaskulære sygdomme Ikke almindelig: Vasculitis.
English: Metabolism and nutrition disorders Uncommon: Anorexia, hyperglycaemia, hyperuricaemia, hypokalaemia, hyponatraemia
Danish: Metabolisme og ernæring Ikke almindelig: Anoreksi, hyperglykæmi, hyperurikæmi, hypokaliæmi, hyponatriæmi.
English: The use of Cozaar Comp is contra-indicated during the 2nd and 3rd trimester of pregnancy (see section 4.3 and 4.4).
Danish: Anvendelse af losartan er kontraindiceret i 2. og 3. trimester af graviditeten (se pkt.
English: Ireland Merck Sharp & Dohme Limited, Hertford Road,
Danish: Merck Sharp & Dohme Limited, Hertford Road,
English: The concomitant use of potassium sparing diuretics, potassium supplements and potassium containing salt substitutes with losartan/ hydrochlorothiazide is not recommended (see section 4.5).
Danish: Brug af kaliumbesparende diuretika, kaliumtilskud og kaliumholdige salterstatninger sammen med losartan/hydrochlorthiazid anbefales ikke (se pkt.
English: Blood and lymphatic system disorders Uncommon: Anaemia, Henoch-Schönlein purpura, ecchymosis, haemolysis
Danish: Blod og lymfesystem Ikke almindelig: Anæmi, Schönlein-Henochs purpura, ekkymose, hæmolyse.
English: Hepato-biliary disorders Uncommon: Icterus (intrahepatic cholestatis), pancreatitis
Danish: Lever og galdeveje Ikke almindelig: Icterus (intrahepatisk galdestase), pankreatitis.
English: When pregnancy is diagnosed, treatment with Cozaar Comp should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Danish: Når graviditet diagnosticeres, bør behandling med Cozaar Comp. seponeres omgående, og hvis det er hensigtsmæssigt, bør alternativ behandling påbegyndes (se pkt.
English: Eye disorders Uncommon: Blurred vision, burning/stinging in the eye, conjunctivitis, decrease in visual acuity
Danish: Øjne Ikke almindelig: Sløret syn, brænden/stikken i øjnene, konjunktivitis, nedsat synsskarphed.
English: When given concurrently, the following drugs may interact with thiazide diuretics:
Danish: Følgende stoffer kan interagere med thiazider, når de gives samtidigt:
English: Hypotension and Intravascular volume depletion
Danish: Hypotension og intravaskulær væskemangel
English: Concomitant treatment with cyclosporine may increase the risk of hyperuricaemia and gout-type complications.
Danish: Samtidig behandling med cyclosporin kan øge risikoen for hyperurikæmi og komplikationer af arthritis uricatypen.
English: • Anxiety, nervousness, panic disorder (recurring panic attacks), confusion, depression, abnormal dreams, sleep disorders, sleepiness, memory impairment,
Danish: • Angst, nervøsitet, panikangst (tilbagevendende angstanfald), forvirring, depression, unormale drømme, søvnforstyrrelser, søvnighed, nedsat hukommelse
English: After oral use, diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours the antihypertensive effect persists for up to 24 hours.
Danish: Diuresen indtræder inden for 2 timer efter oral administration, topper efter ca. 4 timer og holder ca. 6-12 timer.
English: Periodic monitoring of serum potassium and ECG is recommended when Losartan/hydrochlorothiazide is administered with medicinal products affected by serum potassium disturbances (e.g. digitalis glycosides and antiarrhythmics) and with the following torsades de pointes
Danish: Lægemidler der påvirkes af serumkaliumforstyrrelser Periodisk monitorering af serumkalium og EKG anbefales, når losartan/hydrochlorthiazid administreres sammen med lægemidler, der påvirkes af serumkaliumforstyrrelser (f.eks. digitalisglycosider og antiarytmika) og med følgende torsade de pointes (ventrikulær takykardi) inducerende lægemidler (inklusive nogle antiarytmika), idet hypokaliæmi er en disponerende faktor for torsades de pointes (ventrikulær takykardi):
English: The CHMP considered that the following contra-indications should be included in the SPC in all MSs: Severe renal impairment; Electrolyte disturbances such as hyponatremia, hypokalemia, hypercalcemia; Hyperuricaemia; Pregnancy and lactation; LAPP lactose deficiency; Liver insufficiency; Addison's disease.
Danish: CHMP var af den opfattelse, at følgende kontraindikationer skal inkluderes i produktresuméet i alle medlemsstater: Svært nedsat nyrefunktion; forstyrrelser i elektrolytbalancen såsom hyponatriæmi, hypokaliæmi, hyperkalcæmi; hyperurikæmi; graviditet og amning; laktosemangel (LAPP);
English: - Reduction in risk of cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy.
Danish: -Risikoreduktion af kardiovaskulær morbiditet og mortalitet hos hypertensive patienter med venstresidig ventrikelhypertrofi.
English: NAME OF THE MARKETING AUTHORISATION HOLDER [See Annex I - To be completed nationally] [For referral procedures]
Danish: NAVN PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN [Se Annex I - Udfyldes nationalt]
English: Cozaar Comp 100/12.5 (losartan 100 mg/ HCTZ 12.5 mg) is available for those patients titrated to 100 mg of Cozaar Comp who require additional blood pressure control.
Danish: Cozaar Comp. 100 mg/12,5 mg (losartan 100 mg/hydrochlorthiazid 12,5 mg) er tilgængelig for de patienter, som titreres til 100 mg Cozaar, og som har brug for yderligere blodtrykskontrol.
English: Because of the potential for adverse effects on the nursing infant, Cozaar Comp is contraindicated during breast-feeding (see section 4.3).
Danish: På grund af muligheden for bivirkninger hos det ammede barn er Cozaar Comp. kontraindiceret ved amning (se pkt.
English: The renin-aldosterone link is mediated by angiotensin II and therefore coadministration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with thiazide diuretics.
Danish: Renin-aldosteronbindingen medieres af angiotensin II, og derfor er der tendens til at kaliumtabet, der er forbundet med thiaziddiuretika, ændres, når en angiotensin II-receptoantagonist gives samtidigt.
English: If you forget to take Cozaar Comp
Danish: Hvis De har glemt at tage Cozaar Comp.
English: For patients who do not respond adequately to Cozaar Comp 50 mg/12.5 mg, the dosage may be increased to one tablet of Cozaar Comp 100 mg/25 mg (losartan 100 mg/ HCTZ 25 mg) once daily.
Danish: Til patienter, som ikke reagerer hensigtsmæssigt på Cozaar Comp. 50 mg/12,5 mg, kan dosis øges til én Cozaar Comp. 100 mg/25 mg tablet (losartan 100 mg/hydrochlorthiazid 25 mg) én gang dagligt.
English: Do not take Cozaar Comp
Danish: Tag ikke Cozaar Comp.