FrancophonIA/ELRC3.0 huggingface dataset:
English: Kuvan has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Kuvan nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: Be sure that you know what dose of Kuvan powder your doctor prescribed.
Slovenian: Vedeti morate, kakšen odmerek praška zdravila Kuvan vam je zdravnik predpisal.
English: Kuvan reduces these levels in some patients who respond to BH4 and can help increase the amount of phenylalanine that can be included in the diet.
Slovenian: Zdravilo Kuvan zniža te ravni pri določenih bolnikih, ki se odzovejo na BH4, in tako pomaga, da je lahko količina fenilalanina, ki ga lahko vsebuje hrana, večja.
English: Based on the in vitro and in vivo results, co-administration of Kuvan is unlikely to increase systemic exposure to drugs that are substrates for BCRP.
Slovenian: Na podlagi rezultatov študij in vitro in in vivo ni verjetno, da bi sočasno dajanje zdravila Kuvan povečalo sistemsko izpostavljenost zdravilom, ki so substrati za BCRP.
English: Once responsiveness to the medicinal product has been established, the dose may be adjusted within the range of 5 to 20 mg/kg/day according to response to therapy.
Slovenian: Ko je enkrat ugotovljen odziv na to zdravilo, lahko odmerek prilagajamo v območju od 5 do 20 mg/kg/dan, glede na odziv na zdravljenje.
English: The following definitions apply to the frequency terminology used hereafter: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from available data).
Slovenian: Pogostnosti so opredeljene z naslednjimi izrazi: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov)
English: Volume of dissolution (ml)
Slovenian: Volumen raztopine (ml)
English: The calculated daily dose based on body weight should be rounded to the nearest multiple of 100.
Slovenian: Na podlagi telesne mase izračunani dnevni odmerek je potrebno zaokrožiti na najbližji večkratnik števila 100.
English: Preparing the sachet(s):
Slovenian: Priprava vrečic(e):
English: The dietary phenylalanine intake should be maintained at a constant level during this period.
Slovenian: V tem obdobju je treba vnos fenilalanina s hrano ves čas ohranjati na enaki ravni.
English: You must continue your diet treatment as recommended by your doctor.
Slovenian: Z dietno prehrano, ki vam jo je priporočil zdravnik, morate nadaljevati.
English: Low blood phenylalanine and tyrosine levels
Slovenian: Nizke ravni fenilalanina in tirozina v krvi
English: Sustained or recurrent dysfunction in the phenylalanine-tyrosine-dihydroxy-L-phenylalanine (DOPA) metabolic pathway can result in deficient body protein and neurotransmitter synthesis.
Slovenian: Dolgotrajne ali ponavljajoče motnje v presnovni poti fenilalanin-tirozin-dihidroksi-L-fenilalanin (DOPA) imajo lahko za posledico nezadostno sintezo beljakovin in nevrotransmiterjev v telesu.
English: - if you are allergic to sapropterin or any of the other ingredients of this medicine (listed in section 6).
Slovenian: - če ste alergični na sapropterin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: If after approximately 4 weeks, a patient's phenylalanine tolerance had not increased by >20% versus baseline, the Kuvan dose was increased in a single step to 20 mg/kg/day.
Slovenian: Če se po približno 4 tednih bolnikova toleranca organizma na fenilalanin ni povečala za > 20 % v primerjavi z izhodiščem, je bil odmerek zdravila Kuvan povečan v enem samem koraku na 20 mg/kg/dan.
English: This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodiumfree'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na tableto, kar v bistvu pomeni 'brez natrija'.
English: Give your child the prescribed amount of solution within 30 minutes after dissolving.
Slovenian: Otroku dajte predpisano količino raztopine v 30 minutah po raztopitvi.
English: • the amount of water needed to mix one dose of Kuvan
Slovenian: • količino vode, potrebne za mešanje enega odmerka zdravila Kuvan
English: Push on the plunger slowly, a small amount at a time, until all of the solution in the oral syringe is given.
Slovenian: Počasi pritiskajte na bat tako, da naenkrat iztisnete majhno količino, dokler ne daste vse raztopine v brizgi za peroralno dajanje.
English: Contents of the pack and other information What Kuvan contains
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Kuvan
English: The most commonly reported adverse reactions are headache and rhinorrhoea.
Slovenian: Neželena učinka, o katerih so poročali najpogosteje, sta glavobol in rinoreja.
English: Respiratory, thoracic and mediastinal disorders Very common:
Slovenian: Bolezni dihal, prsnega koša in mediastinalnega prostora zelo pogosti:
English: In healthy subjects, administration of a single dose of Kuvan at the maximum therapeutic dose of 20 mg/kg had no effect on the pharmacokinetics of a single dose of digoxin (P-gp substrate) administered concomitantly.
Slovenian: Pri zdravih udeležencih dajanje enega odmerka zdravila Kuvan v najvišjem terapevtskem odmerku 20 mg/kg ni imelo nobenega učinka na farmakokinetiko enega odmerka digoksina (substrat za P-gp), danega sočasno.
English: In rats, following intravenous radiolabeled sapropterin administration, radioactivity was found to distribute in foetuses.
Slovenian: Pri podganah so po intravenskem dajanju radioaktivno označenega sapropterina ugotovili, da se radioaktivnost porazdeli v zarodke.
English: Safety and efficacy of Kuvan in patients with renal or hepatic insufficiency have not been established.
Slovenian: Varnost in učinkovitost zdravila Kuvan pri bolnikih z zmanjšanim delovanjem ledvic ali jeter nista bili dokazani.
English: If you are allergic to sapropterin or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Če ste alergični na sapropterin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: The oral syringe and the cup should be stored for next use.
Slovenian: Brizgo za peroralno dajanje in merico je treba shraniti za naslednjo uporabo.
English: Give your child the prescribed amount of solution within 15 to 20 minutes after dissolving.
Slovenian: Otroku dajte predpisano količino raztopine v 15 do 20 minutah po raztopitvi.
English: The solution may then be transferred to another cup for administration of the medicinal product.
Slovenian: Raztopina se nato lahko prenese v drugo merico za dajanje zdravila.
English: Sapropterin is a synthetic version of the naturally occurring 6R-BH4, which is a cofactor of the hydroxylases for phenylalanine, tyrosine and tryptophan.
Slovenian: Sapropterin je sintezna oblika naravno pojavljajočega 6R-BH4, ki je kofaktor hidroksilaz za fenilalanin, tirozin in triptofan.
English: Divide the total daily dose into 2 or 3 doses, taken over the day.
Slovenian: Celoten dnevni odmerek razdelite na dva ali tri odmerke, ki jih razporedite preko dneva.
English: If you forget to take Kuvan
Slovenian: Če ste pozabili vzeti zdravilo Kuvan
English: In the pivotal clinical trials and in the post-marketing experience for Kuvan, the following adverse reactions have been identified.
Slovenian: V ključnih kliničnih preizkušanjih in v obdobju po prihodu zdravila Kuvan na trg so opazili naslednje neželene učinke.
English: Volume of solution to be administered (ml)*
Slovenian: Volumen raztopine za uporabo (ml)*
English: Sapropterin is absorbed after oral administration of the dissolved tablet, and the maximum blood concentration (Cmax) is achieved 3 to 4 hours after dosing in the fasted state.
Slovenian: Sapropterin se po peroralnem zaužitju raztopljene tablete absorbira, najvišja koncentracija v krvi (Cmax) pa je dosežena tri do štiri ure po zaužitju odmerka na tešče.
English: For patients above 20 kg body weight, the calculated daily dose based on body weight should be rounded to the nearest multiple of 100 mg.
Slovenian: Za bolnike s telesno maso več kot 20 kg je treba izračunani dnevni odmerek na podlagi telesne mase zaokrožiti na najbližji večkratnik 100 mg.
English: Sapropterin was found to be weakly mutagenic in bacterial cells and an increase in chromosome aberrations was detected in Chinese hamster lung and ovary cells.
Slovenian: Ugotovili so, da ima sapropterin šibak mutagen učinek na bakterijske celice, pri pljučnih celicah in celicah jajčnikov kitajskih hrčkov pa so zaznali porast kromosomskih aberacij.
English: Drink the dissolved preparation of Kuvan with a meal within 15 to 20 minutes of its preparation.
Slovenian: Raztopljeno zdravilo Kuvan je treba popiti ob obroku v 15 do 20 minutah po pripravi.
English: Do not stop taking Kuvan without prior discussion with your doctor, as phenylalanine levels in your blood may increase.
Slovenian: Z jemanjem zdravila Kuvan ne smete prenehati, ne da bi se pred tem posvetovali s svojim zdravnikom, ker se ravni fenilalanina v vaši krvi lahko zvišajo.
English: Depending on the dose (in mg/kg/day) the appropriate number of tablets should be dissolved in a volume of water as depicted in Tables 1-4, whereby the volume of the solution to be administered is calculated according to the prescribed total daily dose.
Slovenian: Odvisno od odmerka (v mg/kg/dan) je treba ustrezno število tablet raztopiti v volumnu vode, navedenim v preglednicah 1-4, pri čemer se volumen raztopine za uporabo izračuna v skladu s predpisanim skupnim dnevnim odmerkom.
English: The rationale for administration of Kuvan in patients with BH4 Deficiency is to replace the deficient levels of BH4, thereby restoring the activity of phenylalanine hydroxylase.
Slovenian: Osnovni princip zdravljenja z zdravilom Kuvan pri bolnikih s pomanjkanjem BH4 je nadomestitev nezadostnih ravni BH4 in s tem obnovitev aktivnosti fenilalanin hidroksilaze.
English: BH4 is required by the body to use an amino acid called phenylalanine in order to build another amino acid called tyrosine.
Slovenian: Telo spojino BH4 potrebuje, da lahko uporabi aminokislino, imenovano fenilalanin, zato da lahko tvori drugo aminokislino, imenovano tirozin.
English: More frequent monitoring may be required, as blood phenylalanine levels may increase.
Slovenian: Morda bo potrebno pogostejše spremljanje, saj se lahko ravni fenilalanina v krvi zvišajo.
English: Response to this medicinal product is determined by a decrease in blood phenylalanine.
Slovenian: Odziv na to zdravilo se določa z znižanjem ravni fenilalanina v krvi.
English: Your doctor should continue to monitor your blood phenylalanine levels often during your treatment with Kuvan, to make sure that your blood phenylalanine levels are not too high or too low.
Slovenian: Zdravnik mora med zdravljenjem z zdravilom Kuvan še naprej pogosto spremljati ravni fenilalanina v krvi, da zagotovi, da ravni fenilalanina niso previsoke ali prenizke.
English: Based on an in vitro study, there is potential for sapropterin dihydrochloride to inhibit p-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) in the gut at the therapeutic doses.
Slovenian: Na podlagi študije in vitro obstaja možnost, da bo zdravilo sapropterinijev diklorid v terapevtskih odmerkih zaviralo p-glikoprotein (P-gp) in protein odpornosti pri raku dojke (BCRP - breast cancer resistance protein) v črevesju.
English: As HPA due to either PKU or BH4 deficiency is a chronic condition, once responsiveness is demonstrated, Kuvan is intended for long-term use (see section 5.1).
Slovenian: HPA, do katere pride zaradi PKU ali zaradi pomanjkanja BH4, je kronično obolenje, zato je zdravilo Kuvan po tem, ko je bil odziv na zdravljenje dokazan, namenjeno dolgotrajni uporabi (glejte poglavje 5.1).
English: Patients who fail to achieve this level of response within the described one month test period should be considered non-responsive, these patients should not be treated with Kuvan and administration of Kuvan should be discontinued.
Slovenian: Bolnike, pri katerih v opisanem enomesečnem preizkusnem obdobju te stopnje odziva ni bilo mogoče doseči, je treba obravnavati kot neodzivne.
English: Store the oral syringe and the medicine cup for next use.
Slovenian: Brizgo za peroralno dajanje in merico za zdravilo shranite za naslednjo uporabo.
English: Caution must be exercised when prescribing to pregnant women.
Slovenian: Pri predpisovanju zdravila nosečnicam je potrebna previdnost.
English: Kuvan is not expected to affect the ability to drive and use machines.
Slovenian: Zdravilo Kuvan naj ne bi vplivalo na sposobnost vožnje in upravljanja s stroji.
English: For PKU patients, the total daily dose is taken once a day at the same time each day, preferably in the morning.
Slovenian: Bolniki s PKU vzamejo celoten dnevni odmerek enkrat dnevno, vsak dan ob istem času, najbolje zjutraj.
English: Your doctor will monitor the restriction of dietary phenylalanine intake prior and during pregnancy.
Slovenian: Zdravnik bo nadziral omejitev vnosa fenilalanina s hrano pred in med nosečnostjo.
English: Convulsions disorders
Slovenian: Pojav konvulzij
English: • Open the sachet(s) of Kuvan powder for oral solution by folding and tearing, or cutting at the dotted line in the upper right corner of the sachet.
Slovenian: • Odprite vrečico(ce) zdravila Kuvan prašek za peroralno raztopino tako, da jo prepognete in odtrgate ali prerežete vzdolž črtkane črte v zgornjem desnem robu vrečice.
English: Patients should be advised not to swallow the desiccant capsule found in the bottle.
Slovenian: Bolnike je potrebno opozoriti, da ne smejo pogoltniti kapsule s sušilnim sredstvom, ki se nahaja v plastenki.
English: The rate and extent of absorption of sapropterin is influenced by food.
Slovenian: Hrana vpliva na hitrost in obseg absorbcije sapropterina.
English: However, sapropterin has not been shown to be genotoxic in the in vitro test with human lymphocytes as well as in in vivo micronucleus mouse tests.
Slovenian: Vendar pa za sapropterin niso ugotovili, da bi v in vitro raziskavi s človeškimi limfociti niti v in vivo preizkusu z mikronukleusi pri miših deloval genotoksično.
English: Caution should be exercised when prescribing Kuvan to patients receiving treatment with levodopa.
Slovenian: Previdnost je potrebna, kadar se zdravilo Kuvan predpisuje bolnikom, ki se zdravijo z levodopo.
English: Blood phenylalanine and tyrosine levels should be tested, particularly in the paediatric population, one to two weeks after each dose adjustment and monitored frequently thereafter, under the direction of the treating physician.
Slovenian: Raven fenilalanina in tirozina v krvi je treba preveriti, zlasti pri pediatrični populaciji, en do dva tedna po vsaki prilagoditvi odmerka, nato pa pogosto spremljati po navodilih lečečega zdravnika.
English: Following oral administration it is mainly eliminated through faeces while a small proportion is excreted in urine.
Slovenian: Po peroralnem dajanju se izloča pretežno z blatom, medtem ko se majhen delež izloča s sečem.
English: How to take Kuvan
Slovenian: Kako jemati zdravilo Kuvan
English: 56 paediatric PKU patients <4 years of age were randomised 1:1 to receive either 10 mg/kg/day Kuvan in conjunction with a phenylalanine-restricted diet (n=27), or just a phenylalanine-restricted diet (n=29) over a 26-week Study Period.
Slovenian: 56 pediatričnih bolnikov s PKU, starih < 4 leta, je bilo randomiziranih v razmerju 1:1 za prejemanje bodisi 10 mg/kg/dan zdravila Kuvan in diete z omejitvijo fenilalanina (n = 27) ali le diete z omejitvijo fenilalanina (n = 29) v 26-tedenskem obdobju študije.
English: Both parts of the oral syringe and the cup should be washed with warm water and air dry.
Slovenian: Oba dela brizge za peroralno dajanje in merico je treba umiti s toplo vodo in pustiti, da se osušijo na zraku.
English: Limited studies have been conducted in patients under 4 years of age with BH4 deficiency using another formulation of the same active substance (sapropterin) or an un-registered preparation of BH4.
Slovenian: Pri otrocih, mlajših od 4 let, s pomanjkanjem BH4 so izvedli le redke študije, v katerih so uporabili drugo obliko iste učinkovine (sapropterin) ali neregistrirano zdravilo z BH4.
English: The absorption of sapropterin is higher after a high-fat, high-calorie meal as compared to fasting, resulting, in average, in 40-85% higher maximum blood concentrations achieved 4 to 5 hours after administration.
Slovenian: Absorbcija sapropterina je večja po obroku hrane z veliko količino maščob, ki vsebuje veliko kalorij, v primerjavi z zaužitjem zdravila na tešče, pri čemer so štiri do pet ur po zaužitju zdravila najvišje koncentracije v krvi za povprečno 40 do 85 % višje.
English: In the clinical trial extension period, patients maintained dietary phenylalanine tolerance while on Kuvan treatment in conjunction with a Phe-restricted diet, demonstrating sustained benefit over 3.5 years.
Slovenian: V obdobju podaljšanja kliničnega preskušanja so bolniki med zdravljenjem z zdravilom Kuvan in dieto z omejitvijo fenilalanina vzdrževali toleranco organizma na fenilalanin vnesen s hrano, pri čemer so dokazali, da so se koristni učinki ohranjali več kot 3,5 leta.
English: In particular you should tell your doctor if you are using: - levodopa (used to treat Parkinson's disease) - medicines for treatment of cancer (e.g. methotrexate) - medicines for treatment of bacterial infections (e.g. trimethoprim) - medicines that cause dilation of blood vessels, (such as glyceryl trinitrate (GTN), isosorbide dinitrate (ISDN), sodium nitroprusside (SNP), molsidomin, minoxidil).
Slovenian: Zdravniku povejte še zlasti, če uporabljate: - levodopo (uporablja se za zdravljenje Parkinsonove bolezni), - zdravila za zdravljenje raka (npr. metotreksat), - zdravila za zdravljenje bakterijskih okužb (npr. trimetoprim), - zdravila, ki povzročajo razširitev krvnih žil (npr. gliceriltrinitrat (GTN), izosorbid dinitrat
English: Maternal blood phenylalanine levels must therefore be strictly controlled before and during pregnancy.
Slovenian: Raven fenilalanina v krvi pri materi mora biti zato pred in med nosečnostjo strogo nadzorovana.
English: You should not take this medicine if you are breast-feeding.
Slovenian: Tega zdravila med dojenjem ne smete jemati.
English: The results of these studies demonstrate the efficacy of Kuvan to reduce blood phenylalanine levels and to increase dietary phenylalanine tolerance.
Slovenian: Rezultati teh študij dokazujejo učinkovitost zdravila Kuvan pri zmanjševanju ravni fenilalanina v krvi in povečanje tolerance organizma na fenilalanin vnesen s hrano.
English: It is recommended that blood phenylalanine and tyrosine levels be tested one or two weeks after each dose adjustment and monitored frequently thereafter under the direction of the treating physician.
Slovenian: Priporočljivo je, da se ravni fenilalanina in tirozina v krvi preveri en teden ali dva tedna po vsaki prilagoditvi odmerka in se jih pogosto spremlja tudi v nadaljevanju zdravljenja v skladu z navodili lečečega zdravnika.
English: In a further clinical trial, approximately 30% of the 27 children aged below 4 years who received treatment with sapropterin dihydrochloride (10 or 20 mg/kg/day) experienced adverse reactions.
Slovenian: V nadaljnjem kliničnem preskušanju je imelo neželene učinke približno 30 % od 27 otrok, starih manj kot 4 leta, ki so se zdravili s sapropterinijevim dikloridom (10 ali 20 mg/kg/dan).
English: Take Kuvan as a single daily dose with a meal to increase the absorption, and at the same time each day, preferably in the morning.
Slovenian: Zdravilo Kuvan vzemite v enkratnem dnevnem odmerku ob obroku hrane, ki poveča absorpcijo, vsak dan ob istem času, najbolje zjutraj.
English: Kuvan contains the active substance sapropterin which is a synthetic copy of a body's own substance called tetrahydrobiopterin (BH4).
Slovenian: Zdravilo Kuvan vsebuje učinkovino sapropterin, ki je sintezna oblika telesu lastne snovi, imenovane tetrahidrobiopterin (BH4).
English: If you take more Kuvan than you should
Slovenian: Če ste vzeli večji odmerek zdravila Kuvan, kot bi smeli
English: Patients treated with Kuvan must continue a restricted phenylalanine diet and undergo regular clinical assessment (such as monitoring of blood phenylalanine and tyrosine levels, nutrient intake, and psycho-motor development).
Slovenian: Bolniki, ki se zdravijo z zdravilom Kuvan, morajo nadaljevati s prehrano z omejenim vnosom fenilalanina ter potrebujejo redno klinično oceno (kot je spremljanje ravni fenilalanina in tirozina v krvi, vnos hranil in psihomotorični razvoj).
English: Treatment with sapropterin may decrease blood phenylalanine levels below the desired therapeutic level.
Slovenian: Zdravljenje s sapropterinom lahko zniža ravni fenilalanina v krvi pod zaželeno terapevtsko raven.
English: It was intended that all patients maintained blood phenylalanine levels within a range of 120-360 µmol/l (defined as ≥120 to <360 µmol/l) through monitored dietary intake during the 26-week Study Period.
Slovenian: Namen je bil, da se pri vseh bolnikih vzdržujejo ravni fenilalanina v krvi v razponu 120-360 µmol/l (opredeljeno kot ≥ 120 do < 360 µmol/l) z nadzorovanim vnosom hrane v 26-tedenskem obdobju študije.
English: In 88 subjects with poorly controlled PKU who had elevated blood phenylalanine levels at screening, sapropterin dihydrochloride 10 mg/kg/day significantly reduced blood phenylalanine levels as compared to placebo.
Slovenian: Pri 88 osebah s slabo nadzorovano PKU, ki so imeli ob presejanju povečano raven fenilalanina v krvi, je sapropterinijev diklorid v odmerku 10 mg/kg na dan pomembno znižal raven fenilalanina v krvi v primerjavi s placebom.
English: (GTN), isosorbide dinitrate (ISDN), sodium nitroprusside (SNP), molsidomin), phosphodiesterase type 5 (PDE-5) inhibitors and minoxidil.
Slovenian: (ISDN), natrijev nitroprusid (SNP), molsidomin, minoksidil).
English: Kuvan is used to treat hyperphenylalaninaemia (HPA) or phenylketonuria (PKU) in patients of all ages.
Slovenian: Zdravilo Kuvan se uporablja za zdravljenje hiperfenilalaninemije (HPA) ali fenilketonurije (PKU) pri bolnikih vseh starosti.
English: These devices are supplied to the specialized paediatric centers for inborn errors of metabolism to be provided to the caregivers of the patients.
Slovenian: Ti pripomočki so na voljo v specializiranih pediatričnih centrih za novorojenčke s prirojenimi presnovnimi motnjami, kjer jih dobijo negovalci bolnikov.
English: Total dose (mg/day)
Slovenian: Celotni odmerek (mg/dan)
English: The most commonly reported adverse reactions are “amino acid level decreased” (hypophenylalaninaemia), vomiting and rhinitis.
Slovenian: Neželeni učinki, o katerih so poročali najpogosteje, so "znižana raven aminokislin" (hipofenilalaninemija), bruhanje in rinitis.
English: Caution is recommended during concomitant use of Kuvan with all medicinal products that cause vasodilation, including those administered topically, by affecting nitric oxide (NO) metabolism or action including classical NO donors (e.g. glyceryl trinitrate (GTN), isosorbide dinitrate (ISDN), sodium nitroprusside (SNP), molsidomin), phosphodiesterase type 5 (PDE-5) inhibitors and minoxidil.
Slovenian: Previdnost je priporočljiva med sočasno uporabo zdravila Kuvan z vsemi zdravili, ki povzročajo vazodilatacijo, vključno s tistimi, ki se uporabljajo topikalno, tako da vplivajo na presnovo ali delovanje dušikovega oksida (NO), vključno z klasičnimi donorji NO (npr. gliceriltrinitrat (GTN), izosorbid dinitrat (ISDN), natrijev nitroprusid (SNP), molsidomin), zaviralci fosfodiesteraze tipa 5 (PDE-5) in minoksidilom.
English: The prescribed number of tablets for a 2, 5, 10 and 20 mg/kg/day dose should be placed in a cup (that shows the appropriate graduation markings at 20, 40, 60 and 80 ml) with the amount of water as depicted in Tables 1-4 and stirred until dissolved.
Slovenian: Predpisano število tablet za odmerek 2, 5, 10 in 20 mg/kg/dan je treba dati v merico (na njem so ustrezne oznake za 20, 40, 60 in 80 ml) s količino vode, navedeno v preglednicah 1-4, in jih mešati, dokler se ne raztopijo.