FrancophonIA/ELRC3.0 huggingface dataset:
English: If a combined inducer of these UGT enzymes and transport proteins must be co-administered with canagliflozin, monitoring of glycaemic control to assess response to canagliflozin is appropriate.
Croatian: U slučaju da se kombinirani induktori ovih UGT enzima i transportnih proteina moraju primijeniti istodobno s kanagliflozinom, prikladno je praćenje regulacije glikemije radi procjene odgovora na kanagliflozin.
English: Canagliflozin has no or negligible influence on the ability to drive and use machines.
Croatian: Kanagliflozin ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Invokana contains lactose
Croatian: Što Invokana sadrži
English: In rare instances, phimosis was reported and sometimes circumcision was performed.
Croatian: U rijetkim slučajevima, prijavljena je fimoza te je u nekim slučajevima izvršeno obrezivanje.
English: Among female patients taking canagliflozin, 2.3% experienced more than one infection.
Croatian: Među ženskim bolesnicima koje uzimaju kanagliflozin; 2,3% je doživjelo više od jedne infekcije.
English: Enzyme inducers (such as St. John's wort [Hypericum perforatum], rifampicin, barbiturates, phenytoin, carbamazepine, ritonavir, efavirenz) may give rise to decreased exposure of canagliflozin.
Croatian: Induktori enzima (poput gospine trave [Hypericum perforatum], rifampicin, barbiturati, fenitoin, karbamazepin, ritonavir, efavirenz) mogu dovesti do smanjene izloženosti kanagliflozinu.
English: b Thirst includes the terms thirst, dry mouth, and polydipsia.
Croatian: b Žeđ uključuje pojmove žeđ, suha usta i polidipsija.
English: • At the request of the European Medicines Agency;
Croatian: Nadopunjeni RMP treba dostaviti: • Na zahtjev Europske agencije za lijekove;
English: The reductions in RTG and increases in UGE were sustained over a 26-week dosing period in patients with type 2 diabetes.
Croatian: Smanjenja RTG i povišenja UGE zadržala su se kroz 26-tjedno razdoblje doziranja u bolesnika s dijabetesom tipa
English: In rare instances, phimosis was reported and sometimes circumcision was performed (see section 4.4).
Croatian: U rijetkim slučajevima, prijavljena je fimoza, te je u nekim slučajevima izvršeno obrezivanje (vidjeti dio 4.4).
English: It is unknown whether canagliflozin and/or its metabolites are excreted in human milk.
Croatian: Nije poznato izlučuju li se kanagliflozin i/ili njegovi metaboliti u majčino mlijeko u ljudi.
English: In patients susceptible to greater reductions in intravascular volume as described above, larger decreases in eGFR (> 30%) were sometimes seen, which subsequently improved, and infrequently required interruption of treatment with canagliflozin (see section 4.8).
Croatian: U bolesnika koji su osjetljivi na veće redukcije intravaskularnog volumena, kao što je opisano iznad, ponekad su primijećena veća smanjenja eGFR (> 30%), uz naknadna poboljšanja, koja su manje često zahtijevala prekid liječenja kanagliflozinom (vidjeti dio 4.8).
English: • If your doctor has prescribed canagliflozin along with any bile acid sequestrant such as cholestyramine (medicines for lowering cholesterol) you should take canagliflozin at least 1 hour before or 4 hours to 6 hours after the bile acid sequestrant.
Croatian: • Ako Vam je liječnik propisao kanagliflozin zajedno s bilo kojim od lijekova koji vežu žučnu kiselinu, poput kolestiramina (lijekovi za snižavanje kolesterola), kanagliflozin morate uzeti najmanje 1 sat prije ili 4 sata do 6 sati nakon lijeka koji veže žučnu kiselinu.
English: Patients with baseline HbA1c > 10% to ≤ 12%
Croatian: Bolesnici s početnom vrijednosti HbA1c > 10% do ≤ 12%
English: Adverse reactions leading to discontinuation of ≥ 0.5% of all canagliflozin-treated patients in these studies were vulvovaginal candidiasis (0.7% of female patients) and balanitis or balanoposthitis (0.5% of male patients).
Croatian: Nuspojave koje su dovele do prekida liječenja kod ≥ 0,5% svih bolesnika liječenih kanagliflozinom u ovim ispitivanjima bile su vulvovaginalna kandidijaza (0,7% ženskih bolesnika) i balanitis ili balanopostitis (0,5% muških bolesnika).
English: Two hundred eleven (211) patients from the clinical study in older patients participated in a body composition substudy using DXA body composition analysis.
Croatian: Dvjesto i jedanaest (211) bolesnika iz kliničkih ispitivanja sa starijim bolesnicima sudjelovali su u podispitivanju sastava tijela korištenjem DXA
English: Insulin and insulin secretagogues, such as sulphonylureas, can cause hypoglycaemia.
Croatian: Inzulin i inzulinski sekretagozi, poput sulfonilureja, mogu uzrokovati hipoglikemiju.
English: Patients with diabetes have been shown to have elevated renal glucose reabsorption which may contribute to persistent elevated blood glucose concentrations.
Croatian: Pokazalo se da bolesnici s dijabetesom imaju povišenu reapsorpciju glukoze u bubrezima što može doprinijeti trajno povišenim koncentracijama šećera u krvi.
English: • cholestyramine (medicine used to reduce cholesterol levels in the blood).
Croatian: • kolestiramin (lijek koji se uzima za smanjenje razine kolesterola u krvi).
English: A total of 10,285 patients with type 2 diabetes participated in nine double-blind, controlled clinical efficacy and safety studies conducted to evaluate the effects of Invokana on glycaemic control.
Croatian: Ukupno 10 285 bolesnika s dijabetesom tipa 2 sudjelovalo je u devet dvostruko slijepih, kontroliranih ispitivanja kliničke djelotvornosti i sigurnosti koje su provedene radi procjene djelotvornosti lijeka Invokana na regulaciju glikemije.
English: The apparent terminal half-life (t1/2) (expressed as mean ± standard deviation) was 10.6 ± 2.13 hours and 13.1 ± 3.28 hours for the 100 mg and 300 mg doses, respectively.
Croatian: Prividno završno poluvrijeme (t1/2) (izraženo kao srednja vrijednost ± standardna devijacija) bilo je 10,6 ± 2,13 sati i 13,1 ± 3,28 sati za dozu od 100 mg odnosno od 300 mg.
English: • efavirenz or ritonavir (a medicine used to treat HIV infection)
Croatian: • efavirenz ili ritonavir (lijek koji se uzima za liječenje HIV infekcije)
English: Plasma protein binding is not meaningfully altered in patients with renal or hepatic impairment.
Croatian: Vezanje na proteine nije značajno promijenjeno u bolesnika s oštećenjem bubrega ili jetre.
English: Plasma Cmax and AUC of canagliflozin increased in a dose-proportional manner from 50 mg to 300 mg.
Croatian: Cmax i AUC kanagliflozina u plazmi povisili su se proporcionalno dozi od 50 mg do 300 mg.
English: • blood tests may show changes related to kidney function (creatinine or urea) or potassium
Croatian: • krvne pretrage mogu pokazati promjene povezane s bubrežnom funkcijom (kreatinin ili urea) ili kalijem
English: Adverse reactions reported from world-wide postmarketing use of canagliflozin are also included in this tabulation.
Croatian: Nuspojave prijavljene tijekom primjene kanagliflozina nakon stavljanja u promet u svijetu su također uključene u ovu tablicu.
English: In in vitro studies, canagliflozin neither inhibited cytochrome P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, or CYP2E1, CYP2B6, CYP2C8, CYP2C9, nor induced CYP1A2, CYP2C19, CYP2B6, CYP3A4 at higher than therapeutic concentrations.
Croatian: U in vitro ispitivanjima, pri koncentracijama višim od terapijskih, kanagliflozin niti je inhibirao citokrome P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, ili CYP2E1, CYP2B6, CYP2C8, CYP2C9, niti je inducirao CYP1A2, CYP2C19, CYP2B6, CYP3A4.
English: Among male patients taking canagliflozin, 0.9% had more than one infection.
Croatian: Među muškim bolesnicima koji uzimaju kanagliflozin 0,9% imalo je više od jedne infekcije.
English: To control your diabetes, you still need to follow the advice about diet and exercise from your doctor, pharmacist or nurse.
Croatian: Kako biste kontrolirali svoju šećernu bolest i dalje morate slijediti savjete o dijeti i tjelovježbi koje ste dobili od svog liječnika, ljekarnika ili medicinske sestre.
English: 5.3 Pre-clinical safety data
Croatian: 5.3 Neklinički podaci o sigurnosti primjene
English: These decreases in exposure to canagliflozin may decrease efficacy.
Croatian: Ovo smanjenje izloženosti kanagliflozinu može smanjiti djelotvornost.
English: CYP3A4-mediated (oxidative) metabolism of canagliflozin is minimal (approximately 7%) in humans.
Croatian: Metabolizam kanagliflozina posredovan s CYP3A4 (oksidativni) u ljudi je minimalan (približno 7%).
English: • dabigatran (blood thinner medicine that lowers the risk of blood clot formation).
Croatian: • dabigatran (lijek za razrjeđivanje krvi koji smanjuje rizik za formiranje krvnog ugruška).
English: This effect at the 300 mg dose of canagliflozin may, in part, be due to local inhibition of intestinal SGLT1 (an important intestinal glucose transporter) related to transient high concentrations of canagliflozin in the intestinal lumen prior to medicinal product absorption (canagliflozin is a low potency inhibitor of the SGLT1 transporter).
Croatian: Ovaj učinak pri dozi od 300 mg kanagliflozina može djelomično biti uslijed lokalne inhibicije crijevnog SGLT1 (važan crijevni transporter glukoze), vezano uz prolazno visoke koncentracije kanagliflozina u crijevnom lumenu prije apsorpcije lijeka (kanagliflozin je niskopotentni inhibitor SGLT1 transportera).
English: For patients receiving canagliflozin, in case of intercurrent conditions that may lead to volume depletion (such as a gastrointestinal illness), careful monitoring of volume status (e.g., physical examination, blood pressure measurements, laboratory tests including renal function tests), and serum electrolytes is recommended.
Croatian: Za bolesnike koji uzimaju kanagliflozin, u slučaju interkurentnih stanja koja mogu dovesti do deplecije volumena (poput gastrointestinalne bolesti), preporučuje se pažljivo praćenje stanja volumena (npr. tjelesni pregledi, mjerenja krvnog tlaka, laboratorijska ispitivanja uključujući ispitivanja bubrežne funkcije) i elektrolita u serumu.
English: Metabolism and nutrition disorders very common
Croatian: Poremećaji metabolizma i prehrane vrlo često
English: Protein binding is independent of canagliflozin plasma concentrations.
Croatian: Vezanje na proteine je neovisno o koncentraciji kanagliflozina u plazmi.
English: A pre-specified interim meta-analysis was conducted of adjudicated major cardiovascular events in the phase 2 and 3 clinical studies in 9,632 patients with type 2 diabetes, including 4,327 patients (44.9%) with cardiovascular disease or at high risk for cardiovascular disease who are participating in an ongoing cardiovascular study.
Croatian: Unaprijed planirana prijevremena meta-analiza provedena je s definiranim velikim kardiovaskularnim događajima iz ispitivanja faze 2 i 3 u 9632 bolesnika s dijabetesom tipa 2, uključujući 4327 bolesnika (44,9%) s kardiovaskularnim bolestima ili s visokim rizikom za kardiovaskularne bolesti, koji su sudjelovali u kardiovaskularnom ispitivanju koje je bilo u tijeku.
English: Canagliflozin is an orally-active inhibitor of SGLT2.
Croatian: Kanagliflozin je oralno djelujući inhibitor SGLT2.
English: • The active substance is canagliflozin.
Croatian: • Djelatna tvar je kanagliflozin.
English: This may affect your ability to drive, cycle, and use any tools or machines.
Croatian: Ovo može utjecati na Vašu sposobnost upravljanja vozilima, biciklom ili sposobnost upotrebe bilo kakvih alata i strojeva.
English: Due to volume depletion, generally small mean decreases in eGFR were seen within the first 6 weeks of treatment initiation with canagliflozin.
Croatian: Zbog deplecije volumena, obično je primjećeno malo smanjenje srednje vrijednosti eGFR tijekom prvih 6 tjedana nakon početka liječenja kanagliflozinom.
English: Male and female patients with a history of genital mycotic infections were more likely to develop an infection.
Croatian: I u muških i ženskih bolesnika s genitalnim gljivičnim infekcijama u anamnezi, infekcije su se češće razvijale.
English: Canagliflozin did not increase the incidence of tumours in male and female mice in a 2-year study at doses of 10, 30, and 100 mg/kg.
Croatian: Kanagliflozin nije povisio incidenciju tumora u mužjaka i ženki miševa u 2-godišnjem ispitivanju pri dozama od 10, 30, i 100 mg/kg.
English: < 60 mL/min/1.73 m2, and patients ≥ 75 years of age had generally higher incidences of these adverse reactions.
Croatian: do < 60 mL/min/1,73 m i bolesnici starosti ≥ 75 godina imali su općenito veće incidencije ovih nuspojava.
English: If interrupted, consideration should be given to more frequent glucose monitoring.
Croatian: Ukoliko je liječenje prekinuto, u obzir treba uzeti čest nadzor glukoze.
English: Adverse reactions in table 1 are based on the pooled analysis of the four 26-week placebo-controlled studies (n = 2,313) described above.
Croatian: Nuspojave u tablici 1 temelje se na analizi udruženih podataka iz četiri 26-tjedna placebom kontrolirana ispitivanja (n = 2313) opisana iznad.
English: Polyuria or Pollakiuriaf, Urinary tract infection (pyelonephritis and urosepsis have been reported postmarketing)
Croatian: Poliurija ili polakizurijaf, infekcija mokraćnog sustava (pijelonefritis i urosepsa prijavljeni nakon stavljanja lijeka u promet)
English: Experience in New York Heart Association (NYHA) class III is limited, and there is no experience in clinical studies with canagliflozin in NYHA class IV.
Croatian: Iskustvo s klasifikacijom New York Heart Associaton (NYHA) III je ograničeno, a nema iskustva u kliničkim ispitivanjima s kanagliflozinom u klasifikaciji NYHA IV. Laboratorijski nalazi mokraće
English: • carbamazepine, phenytoin, or phenobarbital (medicines used to control seizures)
Croatian: • karbamazepin, fenitoin ili fenobarbital (lijekovi koji se uzimaju za kontrolu napadaja)
English: Increases in urinary glucose excretion with Invokana can falsely lower 1,5-anhydroglucitol (1,5-AG) levels and make measurements of 1,5-AG unreliable in assessing glycemic control.
Croatian: Povišenja ekskrecije glukoze urinom uz lijek Invokana mogu lažno sniziti razine 1,5-anhidroglucitola (1,5-AG) te mjerenja 1,5-AG učiniti nepouzdanima u procjeni kontrole glikemije.
English: Therefore, 1,5-AG assays should not be used for assessment of glycemic control in patients on canagliflozin.
Croatian: Stoga se 1,5-AG testovi ne smiju koristiti u svrhu procjene kontrole glikemije u bolesnika na kanagliflozinu.
English: Canagliflozin's action to increase UGE directly lowering plasma glucose is independent of insulin.
Croatian: Djelovanje kanagliflozina na povišenje UGE izravno smanjujući glukozu u plazmi neovisno je o inzulinu.
English: A total of 714 patients ≥ 55 years of age to ≤ 80 years of age (227 patients 65 years of age to < 75 years of age and 46 patients 75 years of age to ≤ 80 years of age) with inadequate glycaemic control on current diabetes treatment (glucose-lowering medicinal products and/or diet and exercise) participated in a double-blind, placebo-controlled study over 26 weeks.
Croatian: Ukupno 714 bolesnika starosti ≥ 55 godina do ≤ 80 godina (227 bolesnika starosti 65 godina do < 75 godina i 46 bolesnika starosti 75 godina do ≤ 80 godina) s neprikladnom regulacijom glikemije s trenutnim liječenjem dijabetesa (lijekovi koji snižavaju glukozu i/ili dijeta i vježba) sudjelovalo je u dvostruko slijepom, placebo-kontroliranom ispitivanju kroz 26 tjedana.
English: In the dedicated cardiovascular study and the larger pooled analysis, discontinuations due to adverse reactions related to volume depletion and serious adverse reactions related to volume depletion were not increased with canagliflozin.
Croatian: U ciljanom kardiovaskularnom ispitivanju i većoj analizi udruženih podataka, prekidi liječenja zbog nuspojava povezanih s deplecijom volumena i zbog ozbiljnih nuspojava povezanih s deplecijom volumena, nisu porasli uz kanagliflozin.
English: Pharmacotherapeutic group: Drugs used in diabetes, other blood glucose lowering drugs, excluding insulins.
Croatian: Farmakoterapijska skupina: Lijekovi za liječenje dijabetesa, ostali lijekovi za sniženje glukoze u krvi, isključujući inzuline.
English: Canagliflozin 100 mg and 300 mg as monotherapy and as dual or triple add-on therapy resulted in statistically significant reductions in the percentage of body weight at 26 weeks relative to placebo.
Croatian: Kanagliflozin od 100 mg i 300 mg kao monoterapija i kao dodatna dvojna i trojna terapija dovela je do statistički značajnih postotaka smanjenja tjelesne težine u 26 tjedana, u odnosu na placebo.
English: The safety and efficacy of canagliflozin in patients with type 1 diabetes have not been established and canagliflozin should not be used for treatment of patients with type 1 diabetes.
Croatian: Sigurnost i djelotvornost kanagliflozina u bolesnika sa šećernom bolešću tipa 1 nisu ustanovljene te se kanagliflozin ne smije primjenjivati u liječenju bolesnika sa šećernom bolešću tipa
English: These increases in canagliflozin exposure are not expected to be clinically relevant.
Croatian: Ne očekuje se da će ova povišenja izloženosti kanagliflozinu biti klinički značajna.
English: Invokana can be used by itself or along with other medicines you may be using to treat your type 2 diabetes (such as metformin, insulin, a DPP-4 inhibitor [such as sitagliptin, saxagliptin, or linagliptin], a sulphonylurea [such as glimepiride or glipizide], or pioglitazone) that lower blood sugar levels.
Croatian: Invokana se može uzimati sama ili zajedno s drugim lijekovima koje možete uzimati za liječenje šećerne bolesti tipa 2 (poput metformina, inzulina, DPP-4 inhibitora [poput sitagliptina, saksagliptina, ili linagliptina], sulfonilureje [poput glimepirida ili glipizida], ili pioglitazona) koji snižavaju razinu šećera u krvi.
English: d Canagliflozin as add-on therapy to insulin (with or without other glucose-lowering medicinal products).
Croatian: d Kanagliflozin kao dodatna terapija s inzulinom (sa ili bez drugih lijekova koji snižavaju glukozu).
English: INFORMATION IN BRAILLE invokana 100 mg invokana 300 mg
Croatian: 16. PODACI NA BRAILLEOVOM PISMU invokana 100 mg invokana 300 mg
English: Before initiating canagliflozin, factors in the patient history that may predispose to ketoacidosis should be considered.
Croatian: Prije početka liječenja kanagliflozinom, potrebno je u anamnezi bolesnika razmotriti moguće predisponirajuće faktore za ketoacidozu.
English: • if you experience rapid weight loss, feeling sick or being sick, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat, contact a doctor or the nearest hospital straight away.
Croatian: • ako iskusite nagli gubitak tjelesne težine, osjećaj mučnine ili povraćanje, bol u trbuhu, prekomjernu žeđ, ubrzano i duboko disanje, smetenost, neuobičajenu pospanost ili umor, zadah slatkog mirisa, slatki ili metalni okus u ustima ili drugačiji miris mokraće ili znoja, odmah se javite liječniku ili u najbližu bolnicu.
English: • feeling thirsty
Croatian: • osjećaj žeđi • mučnina
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Croatian: Ako Vam je liječnik rekao da imate bolest nepodnošenja nekih šećera, prije nego što počnete uzimati ovaj lijek posavjetujete se sa svojim liječnikom.
English: Dabigatran: The effect of concomitant administration of canagliflozin (a weak P-gp inhibitor) on dabigatran etexilate (a P-gp substrate) has not been studied.
Croatian: Dabigatran: Učinak konkomitantne primjene kanagliflozina (slabi P-gp inhibitor) na dabigatran eteksilat (P-gp supstrat) nije ispitan.
English: Urinary uric acid excretion was transiently increased by canagliflozin (increased by 19% compared to baseline on day 1 and then attenuating to 6% on day 2 and 1% on day 13).
Croatian: Kanagliflozin je prolazno povisio izlučivanje mokraćne kiseline mokraćom (povišeno za 19% u usporedbi s početnom vrijednošću na dan 1, smanjujući se na 6% na dan 2 i 1% na dan 13).
English: However, dizziness or lightheadedness has been reported, which may affect your ability to drive, cycle, or use tools or machines.
Croatian: Međutim, prijavljene su omaglica i ošamućenost, koji mogu imati utjecaja na Vašu sposobnost upravljanja vozilima, biciklom i upotrebe alata ili strojeva.
English: Following administration of a single oral [14C]canagliflozin dose to healthy subjects, 41.5%, 7.0%, and
Croatian: Nakon primjene jedne oralne doze [14C]kanagliflozina u zdravih ispitanika, 41,5%; 7,0% i 3,2%
English: The mean steady-state volume of distribution of canagliflozin following a single intravenous infusion in healthy subjects was 119 litres, suggesting extensive tissue distribution.
Croatian: Srednja vrijednost volumena distribucije kangliflozina u stanju dinamičke ravnoteže nakon jedne intravenske infuzije u zdravih ispitanika bila je 119 litara, što ukazuje na opsežnu distribuciju u tkiva.
English: Following co-administration of canagliflozin with rifampicin (an inducer of various active transporters and drug-metabolising enzymes), 51% and 28% decreases in canagliflozin systemic exposure (AUC) and peak concentration (Cmax) were observed.
Croatian: Nakon istovremene primjene kanagliflozina s rifampicinom (induktor različitih aktivnih transportera i enzima koji metaboliziraju lijekove), primijećeno je smanjenje sistemske izloženosti kanagliflozinu (AUC) i vršne koncentracije (Cmax) od 51% i 28%.
English: Canagliflozin showed no effects on fertility and early embryonic development in the rat at exposures up to 19 times the human exposure at the maximum recommended human dose (MRHD).
Croatian: Kanagliflozin nije pokazao učinak na plodnost i rani embrionalni razvoj u štakora pri ekspozicijama 19 puta maksimalno dozvoljenih doza u ljudi (MRHD od engl. maximum recommended human dose).
English: Canagliflozin increased the incidence of testicular Leydig cell tumours in male rats at all doses tested (10, 30, and 100 mg/kg); the lowest dose of 10 mg/kg is approximately 1.5 times the clinical dose of 300 mg based on AUC exposure.
Croatian: Kanagliflozin je povisio incidenciju tumora Leydigovih stanica testisa u mužjaka štakora pri svim ispitanim dozama (10, 30 i 100 mg/kg); najniža doza od 10 mg/kg je približno 1,5 puta kliničke doze od 300 mg na temelju izloženosti AUC.
English: O-glucuronidation is the major metabolic elimination pathway for canagliflozin, which is mainly glucuronidated by UGT1A9 and UGT2B4 to two inactive O-glucuronide metabolites.
Croatian: O-glukuronidacija je glavni metabolički put eliminacije za kanagliflozin, koji većinom prolazi glukuronidaciju putem UGT1A9 i UGT2B4 u dva neaktivna O-glukuronidna metabolita.
English: In a pre- and postnatal development study, canagliflozin administered to female rats from gestation day 6 to lactation day 20 resulted in decreased body weights in male and female offspring at maternally toxic doses > 30 mg/kg/day (exposures ≥ 5.9 times the human exposure to canagliflozin at the MHRD).
Croatian: U pre- i postnatalnom razvojnom ispitivanju, kanagliflozin primijenjen ženkama štakora od gestacijskog dana 6 do dana dojenja 20 rezultiralo je smanjenim tjelesnim težinama i muške i ženske maldunčadi pri toksičnim dozama za majku > 30 mg/kg/dan (izloženosti ≥ 5,9 puta izloženosti kanagliflozinu u ljudi pri MHRD).
English: Canagliflozin is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).
Croatian: Kanagliflozin prenosi P-glikoprotein (P-gp) i protein otpornosti na rak dojke (BCRP, od engl.
English: 10 x 1 film-coated tablets 30 x 1 film-coated tablets 90 x 1 film-coated tablets 100 x 1 film-coated tablets
Croatian: 10 x 1 filmom obložena tableta 30 x 1 filmom obložena tableta 90 x 1 filmom obložena tableta 100 x 1 filmom obložena tableta
English: • low blood sugar levels (hypoglycaemia) - when taking this medicine with insulin or a sulphonylurea (such as glimepiride or glipizide).
Croatian: • niske razine šećera u krvi (hipoglikemija) - kad se ovaj lijek uzima s inzulinom ili sulfonilurejom (poput glimepirida ili glipizida).
English: There are no data from the use of canagliflozin in pregnant women.
Croatian: Nema podataka o primjeni kanagliflozina u trudnica.
English: Genital mycotic infections
Croatian: Genitalne gljivične infekcije