FrancophonIA/ELRC3.0 huggingface dataset:
English: By widening the narrowed arteries, Adempas leads to an improvement in your ability to carry out physical activity.
Danish: Adempas udvider de forsnævrede arterier, hvilket forbedrer din evne til at udføre fysisk aktivitet.
English: 29 to 79
Danish: 29 til 79
English: Pulmonary veno-occlusive disease
Danish: Pulmonal veneokklusiv sygdom
English: Cobicistat, ritonavir, atazanavir and darunavir are additionally classified as CYP3A inhibitors.
Danish: Cobicistat, ritonavir, atazanavir og darunavir er derudover klassificeret som CYP3A-hæmmere.
English: Serious haemoptysis and pulmonary haemorrhage, including cases with fatal outcome have been observed in patients with CTEPH or PAH treated with Adempas (see section 4.4).
Danish: Alvorlig hæmoptyse og lungeblødning, herunder tilfælde med dødelig udgang, er blevet observeret hos patienter med CTEPH eller PAH, som blev behandlet med Adempas (se pkt.
English: Serious haemoptysis occurred in 1% (5/490) patients taking riociguat compared to 0/214 patients taking placebo, including one event with fatal outcome.
Danish: Alvorlig hæmoptyse opstod hos 1 % (5/490) af de patienter, der tog riociguat, sammenlignet med 0/214 af de patienter, der tog placebo, herunder en hændelse med dødelig udgang.
English: Concomitant administration of HAART combinations led to an increase in riociguat mean AUC of up to about 160% and to an approximate 20% increase in mean Cmax.
Danish: Samtidig administration af HAART-kombinationer førte til en stigning i gennemsnitlig riociguat-AUC på op til 160 % og til omtrent 20 % stigning i gennemsnitlig Cmax.
English: Table 6: Effects of riociguat in PATENT-1 on events of clinical worsening Clinical Worsening Events
Danish: Tabel 6: Virkninger af riociguat for PATENT-1 på hændelser med klinisk forværring
English: If you are stopping Adempas to change to another medicine called a PDE5 inihibitor (e.g. sildenafil or tadalafil) you must wait at least 24 hours from your last dose of Adempas before you take the PDE5 inhibitor.
Danish: - Hvis du stopper med at tage Adempas for at skifte til et andet lægemiddel kaldet en PDE5hæmmer (f.eks. sildenafil eller tadalafil), skal du vente mindst 24 timer fra din sidste dosis Adempas, inden du tager PDE5-hæmmeren.
English: There is no clinical experience with riociguat in patients with elevated liver aminotransferases (> 3 x Upper Limit of Normal (ULN)) or with elevated direct bilirubin (> 2 x ULN) prior to initiation of treatment; riociguat is not recommended in these patients.
Danish: Der er ingen klinisk erfaring med riociguat hos patienter med forhøjede lever-aminotransferaser (> 3 x øvre normalgrænse (Upper Limit of Normal, ULN)) eller med forhøjet direkte bilirubin (> 2 x ULN) før behandlingen påbegyndes.
English: If you are stopping tadalafil, you must wait at least 48 hours before you take Adempas.
Danish: - Hvis du stopper med at tage tadalafil, skal du vente mindst 48 timer, inden du tager Adempas.
English: Film-coat:
Danish: Filmovertræk*:
English: Bioavailability (AUC and Cmax) is comparable for Adempas administered orally as a crushed tablet suspended in apple sauce or in water compared to a whole tablet (see section 4.2).
Danish: Biotilgængeligheden (AUC og Cmax) er af samme størrelsesorden, når Adempas administreres oralt som en knust tablet blandet i æblemos eller vand, som når Adempas administreres oralt som en hel tablet (se pkt.
English: Riociguat (2.5 mg three times per day) did not have a clinically meaningful effect on the plasma levels of combined oral contraceptives containing levonorgestrel and ethinyl estradiol when concomitantly administered to healthy female subjects.
Danish: Riociguat (2,5 mg tre gange dagligt) havde ikke nogen klinisk relevant indvirkning på plasmaniveauerne af levonorgestrel og ethinylestradiol i kombinations-p-piller ved samtidig administration til raske kvinder.
English: In some PAH patients, an adequate response on the 6-minute walk distance (6MWD) may be reached at a dose of 1.5 mg three times a day (see section 5.1).
Danish: Hos nogle patienter med PAH kan der opnås et tilstrækkeligt respons på 6-minutters gangtest ved en dosis på 1,5 mg tre gange dagligt (se pkt.
English: In nonsmoking individuals with mild (creatinine clearance 80-50 mL/min), moderate (creatinine clearance <50-30 mL/min) or severe (creatinine clearance <30 mL/min) renal impairment, riociguat plasma concentrations (AUC) were increased by 53%, 139% or 54%, respectively.
Danish: Hos ikke-rygere med let (kreatininclearance 80-50 ml/min), moderat (kreatininclearance < 50-30 ml/min) eller svært (kreatininclearance < 30 ml/min) nedsat nyrefunktion, var plasmakoncentrationerne af riociguat (AUC) forhøjet med hhv. 53 %, 139 % eller
English: The recommended starting dose is a 1-mg tablet taken 3 times a day for 2 weeks.
Danish: Den anbefalede startdosis er 1-mg tablet, der tages 3 gange om dagen i 2 uger.
English: Dose should be increased by 0.5 mg three times daily every two weeks to a maximum of 2.5 mg three times daily, if systolic blood pressure is ≥95 mmHg and the patient has no signs or symptoms of hypotension.
Danish: Dosis bør øges med 0,5 mg tre gange dagligt hver anden uge til maksimalt 2,5 mg tre gange dagligt, hvis det systoliske blodtryk er ≥ 95 mmHg og patienten ikke viser tegn eller symptomer på hypotension.
English: Adempas contains sodium
Danish: Adempas indeholder natrium
English: What you need to know before you take Adempas
Danish: Det skal du vide, før du begynder at tage Adempas
English: In a clinical study the highest dose of Adempas (2.5 mg tablets three times daily) potentiated the blood pressure lowering effect of sublingual nitroglycerin (0.4 mg) taken 4 and 8 hours after intake.
Danish: I et klinisk studie potenserede den højeste dosis af Adempas (2,5 mg tabletter tre gange dagligt) den blodtrykssænkende virkning af sublingual nitroglycerin (0,4 mg), der tages 4 og 8 timer efter indtagelsen af Adempas.
English: Riociguat did not potentiate the bleeding time caused by acetyl-salicylic acid or affect the platelet aggregation in humans.
Danish: Riociguat potenserede ikke den blødningstid, der blev forårsaget af acetylsalicylsyre, og trombocytaggregationen hos mennesker blev heller ikke påvirket.
English: You will receive Adempas only for special types of pulmonary arterial hypertension (PAH), see section 1.
Danish: Du vil kun få Adempas for specielle former for pulmonal arteriel hypertension (PAH), se pkt.
English: Bosentan, reported to be a moderate inducer of CYP3A4, led to a decrease of riociguat steady-state plasma concentrations in PAH patients by 27% (see sections 4.1 and 5.1).
Danish: Bosentan, som er rapporteret til at være en moderat induktor for CYP3A4, førte til nedsatte steadystate plasmakoncentrationer af riociguat hos PAH-patienter med 27 % (se pkt.
English: Use of Adempas in other types of PAH is therefore not recommended.
Danish: Det anbefales derfor ikke at anvende Adempas til andre former for PAH.
English: Concomitant administration of 400 mg once daily ketoconazole led to a 150% (range up to 370%) increase in riociguat mean AUC and a 46% increase in mean Cmax.
Danish: Samtidig administration af 400 mg ketoconazol én gang dagligt medførte 150 % (interval op til 370 %) stigning i gennemsnitligt riociguat-AUC og 46 % stigning i gennemsnitlig Cmax.
English: 25 to 67 [<0.0001]
Danish: 25 til 67 [< 0,0001]
English: Common: may affect up to 1 in 10 people - inflammation of the stomach (gastritis) - inflammation in the digestive system (gastroenteritis) - reduction of red blood cells (anaemia) seen as pale skin, weakness or breathlessness - awareness of an irregular, hard, or rapid heartbeat (palpitation) - low blood pressure (hypotension) - nose bleed (epistaxis) - difficulty breathing through your nose (nasal congestion) - pain in the stomach, intestine or abdomen (gastrointestinal and abdominal pain) - heartburn (gastro-oesophageal reflux disease) - difficulty in swallowing (dysphagia) - constipation - bloating (abdominal distension)
Danish: Almindelig: kan forekomme hos op til 1 ud af 10 personer - Betændelsestilstand i maven (gastritis) - betændelsestilstand i fordøjelsessystemet (gastroenteritis) - reduktion i antallet af røde blodlegemer (anæmi), ses som bleg hud, svaghed eller åndenød - opmærksomhed på et uregelmæssigt, kraftigt eller hurtigt hjerteslag (hjertebanken) - lavt blodtryk (hypotension) - næseblod (epistaxis) - besvær med at trække vejret gennem næsen (tilstopning af næsen) - smerter i maven, tarmen eller bughulen (gastrointestinale og abdominale smerter) - halsbrand (gastroøsofageal reflukssygdom) - synkebesvær (dysfagi) - forstoppelse - oppustethed (udspilet abdomen)
English: Patients treated with riociguat showed significant improvement in Borg CR 10 dyspnoea score (mean change from baseline (SD): riociguat -0.4 (2), placebo 0.1 (2); p = 0.0022).
Danish: Patienterne i behandling med riociguat viste en signifikant forbedring i Borg CR 10 dyspnøscore (gennemsnitlig ændring fra baseline (SD): riociguat -0,4 (2), placebo 0,1 (2), p = 0,0022).
English: 42 film-coated tablets 84 film-coated tablets 90 film-coated tablets 294 film-coated tablets
Danish: 42 filmovertrukne tabletter 84 filmovertrukne tabletter 90 filmovertrukne tabletter 294 filmovertrukne tabletter
English: Survival in patients of WHO functional class II at baseline at 1, 2 and 3 years was 98%, 96% and 93% respectively, and for patients of WHO functional class III at baseline was 96%, 91% and 84% respectively.
Danish: Overlevelse hos patienter med WHO-funktionsklasse II ved baseline og ved 1, 2 og 3 år var henholdsvis 98 %, 96 % og 93 %, og for patienter med WHO-funktionsklasse III ved baseline henholdsvis 96 %, 91 % og
English: Riociguat and its main metabolite are not inhibitors or inducers of major CYP isoforms (including CYP 3A4) or transporters (e.g. P-gp/BCRP) in vitro at therapeutic plasma concentrations.
Danish: Riociguat og den primære metabolit er ikke hæmmere eller induktorer af primære CYP-isoformer (herunder CYP3A4) eller transportører (f.eks. P-gp/BCRP) in vitro ved terapeutiske plasmakoncentrationer.
English: Adempas has moderate influence on the ability to drive and use machines.
Danish: Adempas påvirker i moderat grad evnen til at føre motorkøretøj og betjene maskiner.
English: Further exploratory subgroup analysis revealed a treatment effect of 26 m, (95% CI: 5 m to 46 m) in patients pre-treated with ERAs (n=167) and a treatment effect of 101 m (95% CI: 27 m to 176 m) in patients pre-treated with prostacyclin analogues (n=27).
Danish: En yderligere eksplorativ undergruppeanalyse afdækkede en behandlingsvirkning på 26 m, (95 % CI: 5 m til 46 m) hos patienter, som blev forbehandlet med ERA'er (n=167) og en behandlingsvirkning på 101 m (95 % CI: 27 m til 176 m) hos patienter, som blev forbehandlet med prostacyklinanaloger (n=27).
English: There are no data in patients with severe hepatic impairment (classified as Child Pugh C).
Danish: Der foreligger ingen data for patienter med svært nedsat leverfunktion (klassificeret som Child Pugh C).
English: Table 4: Effects of riociguat on 6MWD in PATENT-1 at last visit Entire patient population Riociguat IDT (n=254)
Danish: Tabel 4: Virkninger af riociguat på den 6-minutters gangtest for PATENT-1 ved sidste besøg Hele patientpopulationen Riociguat IDT (n=254)
English: respective laboratory parameters)
Danish: Anæmi (herunder tilhørende laboratorieparametre)
English: The primary endpoint of the study was placebo-adjusted change from baseline in 6MWD at the last visit (week 12).
Danish: Det primære endepunkt i studiet var en placebojusteret ændring fra baseline i den 6-minutters gangtest ved det sidste besøg (uge 12).
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER - PACKS OF 42, 84, 90, 294 FILM-COATED TABLETS
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP BLISTER - PAKNINGER PÅ 42, 84, 90, 294 FILMOVERTRUKNE TABLETTER
English: Strong CYP1A1 inhibitors should be used with caution (see section 4.4).
Danish: Kraftige CYP1A1-hæmmere bør anvendes med forsigtighed (se pkt.
English: Tadalafil must be discontinued at least 48 hours prior to administration of riociguat.
Danish: Behandlingen med tadalafil skal afbrydes mindst 48 timer før administration af riociguat.
English: The primary endpoint of the study was the placebo adjusted change from baseline in 6-minute walk distance (6MWD) at the last visit (week 16).
Danish: Det primære endepunkt for studiet var den placebojusterede ændring fra baseline i 6-minutter gangtest ved det sidste besøg (uge 16).
English: Patients must not get pregnant during Adempas therapy (see section 4.3).
Danish: Patienterne må ikke blive gravide under behandling med Adempas (se pkt.
English: Riociguat must be discontinued at least 24 hours prior to administration of a PDE5 inhibitor.
Danish: Behandlingen med riociguat skal afbrydes mindst 24 timer før administration af en PDE5-hæmmer.
English: Inhibitors for the UDP-Glykosyltransferases (UGT) 1A1 and 1A9 may potentially increase the exposure of the riociguat metabolite M1, which is pharmacologically active (pharmacological activity: 1/10th to 1/3rd of riociguat).
Danish: Hæmmere af UDP-glykosyltransferaser (UGT) 1A1 og 1A9 kan potentielt øge eksponeringen for riociguat-metabolietten M-1, som er farmakologisk aktiv (farmakologisk aktivitetet: 1/10 til 1/3 af riociguat).
English: Dizziness has been reported and may affect the ability to drive and use machines (see section 4.8).
Danish: Svimmelhed er blevet rapporteret, og det kan påvirke evnen til at føre motorkøretøj og betjene maskiner (se pkt.
English: Riociguat exhibits a reduced solubility at neutral pH vs. acidic medium.
Danish: Riociguat udviser en nedsat opløselighed ved en neutral pH-værdi vs. et surt medium.
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.
Danish: Appendiks V. Ved at indrapportere bivirkninger kan du hjælpe med at fremskaffe mere information om sikkerheden af dette lægemiddel.
English: In PAH, the wall of the blood vessels of the lungs are thickened and the vessels become narrowed.
Danish: Ved PAH er væggene i lungernes blodkar fortykkede, og blodkarrene bliver forsnævrede.
English: Survival in patients of WHO functional class II at baseline at 1, 2 and 3 years was 97%, 94% and 90% respectively, and for patients of WHO functional class III at baseline was 97%, 93% and 88% respectively.
Danish: Overlevelse hos patienter med WHO-funktionsklasse II ved baseline og ved 1, 2 og 3 år var henholdsvis 97 %, 94 % og 90 %, og for patienter med WHO-funktionsklasse III ved baseline, henholdsvis 97 %, 93 % og 88 %.
English: INFORMATION IN BRAILLE Adempas 0.5 mg, 1 mg, 1.5 mg, 2 mg or 2.5 mg
Danish: INFORMATION I BRAILLESKRIFT Adempas 0,5 mg, 1 mg, 1,5 mg, 2 mg eller 2,5 mg
English: The probability of survival at 1 year was 97%, at 2 years 93% and at 3 years 89%.
Danish: Sandsynligheden for overlevelse efter 1 år var 97 %, efter 2 år 93 % og efter 3 år 89 %.
English: Patients with severe hepatic impairment (Child Pugh C) have not been studied and therefore use of Adempas is contraindicated in these patients (see section 4.3).
Danish: Patienter med svært nedsat leverfunktion (Child Pugh C) er ikke blevet undersøgt, og derfor er anvendelsen af Adempas kontraindiceret hos disse patienter (se pkt.
English: A randomised, double-blind, multi-national, placebo controlled, phase III study (PATENT-1) was conducted in 443 adult patients with PAH (riociguat individual dose titration up to 2.5 mg three times daily: n=254, placebo: n=126, riociguat “capped” dose titration (CT) up to 1.5 mg (exploratory dose arm, no statistical testing performed; n=63)).
Danish: Et randomiseret, dobbeltblindet, multinationalt, placebokontrolleret fase III-studie (PATENT-1) blev udført hos 443 voksne patienter med PAH (riociguat individuel dosistitrering op til 2,5 mg tre gange dagligt: n=254, placebo: n=126, riociguat dosistitrering ”med loft” (CT) op til 1,5 mg (eksplorativ dosisarm, ingen statistisk test blev udført, n=63)).
English: Women of childbearing potential / Contraception
Danish: Kvinder i den fertile alder/kontraception
English: This also includes recreational drugs called poppers.
Danish: inklusive de såkaldte poppers (se pkt.
English: Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD).
Danish: Pulmonale vasodilatatorer kan føre til en signifikant forværring af den kardiovaskulære status hos patienter med pulmonal veneokklusiv sygdom.
English: Based on in vitro data riociguat and its main metabolite are substrates of the transporter proteins P-gp (P-glycoprotein) and BCRP (breast cancer resistance protein).
Danish: Baseret på in vitro-data er riociguat og den primære metabolit substrater for transportproteinerne P-gp (P-glykoprotein) og BCRP (brystcancer-resistensprotein).
English: Adverse reactions were similar to those seen at lower doses (see section 4.8).
Danish: Bivirkningerne var sammenlignelige med dem, der blev observeret ved lavere doser (se pkt.
English: A randomised, double-blind, multi-national, placebo controlled, phase III study (CHEST-1) was conducted in 261 adult patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) (72%) or persistent or recurrent CTEPH after pulmonary endarterectomy (PEA; 28%).
Danish: Et randomiseret, dobbeltblindet, multinationalt placebokontrolleret, fase III-studie (CHEST-1) blev udført hos 261 voksne patienter med inoperabel kronisk tromboembolisk pulmonal hypertension (CTEPH) (72 %) eller persisterende eller tilbagevendende CTEPH efter pulmonal endarterektomi (PEA, 28 %).
English: • Assess the benefit-risk for each patient individually before prescribing Adempas in patients on stable doses of strong multi pathway CYP and P-gp/BCRP inhibitors.
Danish: • Benefit/risk-forholdet vurderes individuelt for hver patient, før Adempas ordineres til patienter, der er på en stabil dosis af stærke multipathway CYP og P-gp/BCRP-hæmmere.
English: Based on the high plasma protein binding riociguat is not expected to be dialysable.
Danish: Baseret på den høje plasmaproteinbinding forventes det ikke, at riociguat kan dialyseres.
English: you have any symptoms of low blood pressure (hypotension) such as dizziness, lightheadedness, or fainting or if you are taking medicines to lower your blood pressure or medicines that cause an increase in urination or if you have problems with your heart or circulation.
Danish: Kontakt lægen, hvis dette sker - du har symptomer på lavt blodtryk (hypotension), såsom svimmelhed, uklarhed eller besvimelse, eller hvis du tager medicin for at sænke dit blodtryk, eller medicin der øger vandladningen, eller hvis du har problemer med dit hjerte eller kredsløbet.
English: Pulmonary arterial hypertension (PAH)
Danish: Pulmonal arteriel hypertension (PAH)
English: These findings were in accordance with improvements in additional haemodynamic parameters.
Danish: Disse fund var i overensstemmelse med forbedringer af yderligere hæmodynamiske parametre.
English: The probability of survival at 1 year was 97%, at 2 years 93% and at 3 years 88%.
Danish: Sandsynligheden for overlevelse efter 1 år var 97 %, efter 2 år 93 % og efter 3 år 88 %.
English: There is increased riociguat exposure in these patients (see section 5.2).
Danish: Der er en øget eksponering for riociguat hos disse patienter (se pkt.
English: If you are transitioning between sildenafil or tadalafil and Adempas If you are stopping sildenafil, you must wait at least 24 hours before you take Adempas.
Danish: Hvis du skifter mellem at tage sildenafil eller tadalafil og Adempas - Hvis du stopper med at tage sildenafil, skal du vente mindst 24 timer, inden du tager Adempas.
English: The class of tyrosine kinase inhibitors was identified as potent inhibitors of CYP1A1, with erlotinib and gefitinib exhibiting the highest inhibitory potency in vitro.
Danish: Klassen af tyrosinkinasehæmmere blev identificeret som kraftige hæmmere af CYP1A1, hvor erlotinib og gefitinib udviste den største hæmningsevne in vitro.
English: Due to the high plasma protein binding riociguat is not expected to be dialysable.
Danish: På grund af den høje plasmaproteinbinding forventes det ikke, at riociguat kan dialyseres.
English: Riociguat restores the NO-sGC-cGMP pathway resulting in a significant improvement of pulmonary vascular haemodynamics and an increase in exercise ability.
Danish: Riociguat genetablerer NO-sGC-cGMP-pathway, og fører til en signifikant forbedring i pulmonal vaskulær hæmodynamik, og en øget fysiske arbejdsevne.
English: For the transition from PDE5 inhibitors to riociguat, median treatment-free time for sildenafil was 1 day and for tadalafil 3 days.
Danish: Median-behandlingsfri perioden for skiftet fra PDE5-hæmmere til riociguat var 1 dag for sildenafil og 3 dage for tadalafil.
English: - if you have increased pressure in your pulmonary circulation associated with scarring of the lungs, of unknown cause (idiopathic pulmonary pneumonia).
Danish: - Hvis du har for højt tryk i lungekredsløbet i forbindelse med dannelse af arvæv i lungerne af ukendt årsag (idiopatisk pulmonal pneumonitis).
English: 29 to 83
Danish: 29 til 83
English: Inoperable patient population
Danish: Inoperabel patientpopulation
English: Film-coat: hydroxypropylcellulose, hypromellose 3 cP, propylene glycol (E 1520) and titanium dioxide (E 171).
Danish: Filmovertræk: Hydroxypropylcellulose, hypromellose 3 cP, propylenglycol (E 1520) og titandioxid (E 171)
English: Crushed tablets
Danish: Knusning af tabletter
English: Table 3: Effects of riociguat in CHEST-1 on PVR, NT-proBNP and WHO functional class at last visit PVR
Danish: Tabel 3: Virkninger af riociguat ved CHEST-1 på PVR, NT-proBNP og WHO-funktionsklasse ved sidste besøg
English: If at any time during the up-titration phase systolic blood pressure decreases below 95 mmHg and the patient shows signs or symptoms of hypotension the current dose should be decreased by 0.5 mg three times daily.
Danish: Hvis det systoliske blodtryk på noget tidspunkt under optitreringsfasen falder til under 95 mmHg, og patienten viser tegn eller symptomer på hypotension, skal den aktuelle dosis reduceres med 0,5 mg tre gange dagligt.
English: • certain types of pulmonary arterial hypertension (PAH).
Danish: • visse typer pulmonal arteriel hypertension (PAH).
English: In cirrhotic patients (non-smokers) with moderate hepatic impairment (classified as Child Pugh B), riociguat mean AUC was increased by 51% compared to healthy controls.
Danish: Hos patienter med cirrose (ikke-rygere) med moderat nedsat leverfunktion (klassificeret som Child Pugh B) var gennemsnitlig AUC for riociguat forhøjet med 51 %, sammenlignet med den raske kontrolgruppe.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Danish: Adempas bør ikke anvendes til patienter med arvelig galactoseintolerans, total mangel på lactase eller glucose/galactosemalabsorption.
English: In cirrhotic patients (non-smokers) with mild hepatic impairment (classified as Child Pugh A) riociguat mean AUC was increased by 35% compared to healthy controls, which is within normal intra-individual variability.
Danish: Hos patienter med cirrose (ikke-rygere) og let nedsat leverfunktion (klassificeret som Child Pugh A) var gennemsnitlig AUC for riociguat forhøjet med 35 %, sammenlignet med den raske kontrolgruppe, som ligger inden for den normale intra-individuelle variation.
English: -10 to 63
Danish: -10 til 63
English: Riociguat is a stimulator of soluble guanylate cyclase (sGC), an enzyme in the cardiopulmonary system and the receptor for nitric oxide (NO).
Danish: Riociguat stimulerer den opløselige guanylatcyklase (sGC), der er et enzym i hjerte-kar-systemet inklusive lunger, og er receptor for nitrogenoxid (NO).