FrancophonIA/ELRC3.0 huggingface dataset:
English: What is the risk associated with Rasilamlo?
Slovenian: Kakšna tveganja so povezana z zdravilom Rasilamlo?
English: Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Rasilamlo, including the appropriate precautions to be followed by healthcare professionals and patients.
Slovenian: V skladu s tem načrtom so bile v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo vključene informacije o varnosti, vključno s previdnostnimi ukrepi, ki jih morajo upoštevati zdravstveni delavci in bolniki.
English: Rasilamlo is for use in adults only; it must not be used in children aged less than 2 years and is not recommended for older children.
Slovenian: Ne sme se uporabljati pri otrocih, mlajših od dveh let, medtem ko njegova uporaba pri starejših otrocih ni priporočljiva.
English: It must also not be used in women who are more than three months pregnant or in patients taking medicines containing ciclosporin, itraconazole or other medicines known as ‘potent Pglycoprotein inhibitors' (such as quinidine).
Slovenian: Prav tako ga ne smejo uporabljati ženske, ki so noseče več kot tri mesece, ali bolniki, ki jemljejo zdravila, ki vsebujejo ciklosporin in itrakonazol, ali druga zdravila, znana kot močni zaviralci P-glikoproteina (kot je kinidin).
English: It is available as tablets (150 mg aliskiren and 5 mg amlodipine; 150 mg aliskiren and 10 mg amlodipine; 300 mg aliskiren and 5 mg amlodipine; 300 mg aliskiren and 10 mg amlodipine).
Slovenian: Na voljo je v obliki tablet (150 mg aliskirena in 5 mg amlodipina; 150 mg aliskirena in 10 mg amlodipina; 300 mg aliskirena in 5 mg amlodipina; 300 mg aliskirena in 10 mg amlodipina).
English: Rasilamlo is used to treat essential hypertension (high blood pressure) in adults whose blood pressure is not adequately controlled with aliskiren or amlodipine used alone.
Slovenian: Zdravilo Rasilamlo se uporablja za zdravljenje esencialne hipertenzije (visokega krvnega tlaka) pri odraslih, pri katerih krvni tlak ni ustrezno uravnan z jemanjem samo aliskirena ali amlodipina.
English: Rasilamlo must not be used in people who are hypersensitive (allergic) to aliskiren, amlodipine, to any of the other ingredients of the medicine or other substances derived from dihydropyridine (a group that includes amlodipine).
Slovenian: Zdravila Rasilamlo ne smejo uporabljati osebe, ki so preobčutljive za (alergične na) aliskiren, amlodipin ali katero koli drugo sestavino zdravila ali druge snovi, pridobljene iz dihidropiridina (skupine zdravil, v katero spada tudi amlodipin).
English: The most common side effects with Rasilamlo are hypotension (low blood pressure) and peripheral oedema (swelling, especially of the ankles and feet).
Slovenian: Najpogostejša neželena učinka zdravila Rasilamlo sta hipotenzija (nizek krvni tlak) in periferni edemi (otekanje, zlasti gležnjev in stopal).
English: The dose may be adjusted based on the side effects the patient experienced with their previous treatment with aliskiren or amlodipine and also on how the patient responds to treatment with Rasilamlo.
Slovenian: Odmerek se lahko prilagodi glede na neželene učinke, ki so se pri bolniku pojavljali med predhodnim zdravljenjem z aliskirenom ali amlodipinom, ter glede na njegov odziv na zdravljenje z zdravilom Rasilamlo.
English: The strength of the tablet the patient takes depends on the doses of aliskiren or amlodipine that they received previously.
Slovenian: Jakost tablete, ki jo bolnik jemlje, je odvisna od odmerkov aliskirena ali amlodipina, ki ju je bolnik jemal pred tem.
English: It must not be used in patients with a history of angioedema (swelling beneath the skin) with aliskiren, hereditary angioedema or angioedema of no obvious cause, severe hypotension, shock, narrowing of the aortic heart valve or in patients with heart failure after a heart attack.
Slovenian: Ne smejo ga uporabljati bolniki, pri katerih se je zaradi jemanja aliskirena pojavil angioedem (podkožno otekanje), bolniki z dednim angioedemom ali angioedemom brez očitnega vzroka, osebe s hudo hipotenzijo, osebe v šoku, osebe z zoženjem aortne srčne zaklopke in bolniki s srčnim popuščanjem po srčni kapi.
English: For the full list of all side effects reported with Rasilamlo, see the package leaflet.
Slovenian: Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Rasilamlo, glejte navodilo za uporabo.
English: How has Rasilamlo been studied?
Slovenian: Kako je bilo zdravilo Rasilamlo raziskano?
English: Why has Rasilamlo been approved?
Slovenian: Zakaj je bilo zdravilo Rasilamlo odobreno?
English: Rasilamlo can be used with other antihypertensive medicines, with the exception of ‘angiotensin converting enzyme (ACE) inhibitors' or ‘angiotensin receptor blockers' (ARBs) in patients with diabetes, or moderate or severe kidney impairment.
Slovenian: Zdravilo Rasilamlo se lahko uporablja sočasno z drugimi zdravili za zdravljenje hipertenzije z izjemo zaviralcev angiotenzinske konvertaze (ACE) ali zaviralcev angiotenzinskih receptorjev (ARB) pri bolnikih s sladkorno boleznijo oziroma zmerno ali hudo okvaro ledvic.
English: In the first study, patients taking Rasilamlo 300/10 mg and 300/5 mg had a fall in their sitting diastolic blood pressure of 13.1 mmHg and 10.5 mmHg, respectively, compared with a fall of 5.8 mmHg in patients taking aliskiren 300 mg.
Slovenian: V prvi študiji se je pri bolnikih, ki so jemali zdravilo Rasilamlo v odmerku 300/10 mg oz. 300/5 mg, diastolični krvni tlak v sedečem položaju znižal za 13,1 mmHg oz. 10,5 mmHg v primerjavi z znižanjem za 5,8 mmHg pri bolnikih, ki so jemali 300 mg aliskirena.
English: Rasilamlo was more effective at controlling essential hypertension than placebo, aliskiren or amlodipine used alone.
Slovenian: Zdravilo Rasilamlo je bilo pri uravnavanju esencialne hipertenzije učinkovitejše od placeba, aliskirena ali amlodipina kot samostojnih zdravil.
English: Rasilamlo is a medicine that contains the active substances aliskiren and amlodipine.
Slovenian: Rasilamlo je zdravilo, ki vsebuje zdravilni učinkovini aliskiren in amlodipin.
English: It blocks the activity of a human enzyme called renin, which is involved in the production of a substance called angiotensin I in the body.
Slovenian: Zavira dejavnost človeškega encima, imenovanega renin, ki v telesu sodeluje pri tvorjenju angiotenzina I. Angiotenzin I se pretvori v hormon angiotenzin II, ki deluje kot močan vazokonstriktor (učinkovina, ki oži žile).
English: The third study showed a fall in blood pressure of 8.5 mmHg with Rasilamlo 150/5 mg compared with 8.0 mmHg and 4.8 mmHg with amlodipine 10 mg and 5 mg, respectively.
Slovenian: V tretji študiji se je pri jemanju zdravila Rasilamlo v odmerku 150/5 mg krvni tlak znižal za 8,5 mmHg v primerjavi z 8,0 mmHg oz. 4,8 mmHg pri jemanju amlodipina v odmerku 10 mg oz. 5 mg.
English: Rasilamlo contains two active substances, aliskiren and amlodipine.
Slovenian: Zdravilo Rasilamlo vsebuje dve zdravilni učinkovini, aliskiren in amlodipin.
English: What is Rasilamlo used for?
Slovenian: Za kaj se zdravilo Rasilamlo uporablja?
English: In the second study the falls in blood pressure were 11.0 mmHg and 9.0 mmHg with Rasilamlo 300/10 mg and 150/10mg, respectively, compared with 7.2mmHg with amlodipine 10 mg.
Slovenian: V drugi študiji se je pri jemanju zdravila Rasilamlo v odmerku 300/10 mg oz. 150/10 mg krvni tlak znižal za 11,0 mmHg oz. 9,0 mmHg v primerjavi z znižanjem za 7,2 mmHg pri jemanju 10 mg amlodipina.
English: Rasilamlo in combination with an ACE inhibitor or an ARB must not be used in patients with diabetes, or moderate or severe kidney impairment.
Slovenian: Zdravilo Rasilamlo se v kombinaciji z zaviralcem angiotenzinske konvertaze ali zaviralcem angiotenzinskih receptorjev ne sme uporabljati pri bolnikih s sladkorno boleznijo oziroma zmerno ali hudo okvaro ledvic.
English: How is Rasilamlo used?
Slovenian: Kako se zdravilo Rasilamlo uporablja?
English: How does Rasilamlo work?
Slovenian: Kako zdravilo Rasilamlo deluje?
English: Not known (frequency cannot be estimated from the available data)
Slovenian: Pogostnost neznana (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti)
English: If renal dysfunction is observed, appropriate management and treatment should be prescribed in accordance with standard treatment guidelines.
Slovenian: Če se ugotovi ledvična disfunkcija, je treba predpisati ustrezno obvladovanje in zdravljenje skladno s standardnimi smernicami.
English: OTHER SPECIAL WARNING(S), IF NECESSARY Use only as directed by a doctor.
Slovenian: DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA Uporabljajte samo po zdravnikovih navodilih.
English: For CML, your doctor may prescribe a higher or lower dose depending on how you respond to the treatment.
Slovenian: Pri zdravljenju KML vam lahko zdravnik predpiše večji ali manjši odmerek, odvisno od tega, kako se odzivate na zdravljenje.
English: If you have any questions about how Imatinib Accord works or why this medicine has been prescribed for you, ask your doctor.
Slovenian: Če imate kakšna vprašanja glede tega, kako zdravilo Imatinib Accord deluje ali zakaj vam je bilo predpisano to zdravilo, vprašajte svojega zdravnika.
English: 235 adult patients with accelerated phase disease were enrolled.
Slovenian: Vključili so 235 odraslih bolnikov s pospešeno fazo bolezni.
English: Some children and adolescents taking Imatinib Accord may have slower than normal growth.
Slovenian: Pri nekaterih otrocih in mladostnikih, ki jemljejo zdravilo Imatinib Accord, je lahko rast počasnejša od normalne.
English: Other adverse reactions were reported with lower or equal frequency.
Slovenian: Pri drugih neželenih reakcijah so poročali o manjši ali enaki pogostosti.
English: Frequency categories are defined using the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Slovenian: Kategorije pogostnosti so opredeljene z naslednjim dogovorom: zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10), občasni (≥1/1.000 do <1/100), redki (≥1/10.000 do <1/1.000), zelo redki (<1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: The amount of Imatinib Accord given will depend on your child's condition, body weight and height.
Slovenian: Potrebna količina zdravila Imatinib Accord bo odvisna od otrokovega stanja, telesne mase in višine.
English: Study ADE04 Prephase
Slovenian: Študija ADE04 predhodna faza
English: • Do not use any pack that is damaged or shows signs of tampering.
Slovenian: • Ne uporabite škatle, če je poškodovana ali kaže znake, da je bila že odprta.
English: In all clinical studies 38-40% of patients were > 60 years of age and 10-12% of patients were > 70 years of age.
Slovenian: V vseh kliničnih študijah je bilo 38-40 % bolnikov starih  60 let, 10-12 % bolnikov pa je bilo starih  70 let.
English: If you are unable to swallow the tablets, you can dissolve them in a glass of still water or apple juice:
Slovenian: Če tablet ne morete pogoltniti, jih lahko raztopite v kozarcu navadne vode ali jabolčnega soka:
English: Median age was 51 years (range 18-70 years), with 21.9% of patients ≥ 60 years of age.
Slovenian: Povprečna starost je bila 51 let (razpon 18-70 let), 21,9 % bolnikov je bilo starih ≥ 60 let.
English: Patients should be instructed to use measures such as protective clothing and sunscreen with high sun protection factor (SPF).
Slovenian: Bolnikom je treba naročiti, naj se poslužujejo ukrepov, kot so zaščita z oblačili in uporaba zaščitne kreme z visokim zaščitnim faktorjem (SPF - sun protection factor).
English: Imatinib n=553
Slovenian: n=553
English: Date of first authorization: 01 July 2013 Date of latest renewal: 19th April 2018
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve pridobitve dovoljenja za promet: 1. julij 2013 Datum podaljšanja dovoljenja za promet: 19. april 2018
English: Ki values in human liver microsomes were 27, 7.5 and 7.9 mol/l, respectively.
Slovenian: Vrednosti Ki v mikrosomih človeških jeter so bile 27, 7,5 oziroma 7,9 μmol/l.
English: Other side effects may include
Slovenian: Drugi neželeni učinki lahko vključujejo
English: The decreases in white blood cell (WBC) and neutrophil counts occurred mainly during the first six weeks of therapy, with values remaining relatively stable thereafter.
Slovenian: Do zmanjšanja koncentracij belih krvničk (WBC) in nevtrofilcev je prišlo predvsem v prvih šestih tednih zdravljenja, zatem pa so vrednosti ostale relativno stabilne.
English: Healthcare professionals are asked to report any suspected adverse reactionsvia the national reporting system listed in Appendix V.
Slovenian: Od zdravstvenih delavcev se zahteva, da poročajo o katerem koli domnevnem neželenem učinku zdravila na nacionalni center za poročanje, ki je naveden v Prilogi V.
English: Dermatofibrosarcoma protuberans (DFSP).
Slovenian: - s protuberantnim dermatofibrosarkomom (DFSP).
English: Imatinib pharmacokinetics have not been specifically studied in elderly.
Slovenian: Farmakokinetike imatiniba pri starejših niso posebej proučili.
English: Middlesex, HA1 4HF United Kingdom
Slovenian: Middlesex, HA1 4HF Velika Britanija
English: No specific dose recommendation is necessary in elderly.
Slovenian: Pri starejših niso potrebna posebna priporočila glede odmerjanja.
English: The safety database for children and adolescents with Ph+ALL is very limited though no new safety concerns have been identified.
Slovenian: Čeprav je baza podatkov za otroke in mladostnike s Ph+ ALL zelo majhna, zaenkrat niso odkrili nobenih novih pomislekov glede varnosti.
English: For patients unable to swallow the film-coated tablets, the tablets may be dispersed in a glass of mineral water or apple juice.
Slovenian: Bolnikom, ki ne morejo pogoltniti filmsko obloženih tablet, lahko tablete raztopimo v kozarcu mineralne vode ali jabolčnega soka.
English: Chronic phase, newly diagnosed
Slovenian: Kronična faza, na novo diagnosticirana
English: - Imatinib Accord is not recommended during pregnancy unless clearly necessary as it may harm your baby.
Slovenian: - Uporabe zdravila Imatinib Accord v nosečnosti ne priporočamo, če to ni nujno potrebno, saj lahko škoduje vašemu otroku.
English: Your doctor has prescribed Imatinib Accord because you suffer from a serious condition.
Slovenian: Zdravnik vam je predpisal zdravilo Imatinib Accord, ker imate resno bolezen.
English: Your doctor will discuss with you the possible risks of taking Imatinib Accord during pregnancy.
Slovenian: Zdravnik se bo pogovoril z vami o možnih nevarnostih jemanja zdravila Imatinib Accord v nosečnosti.
English: Since increased vascularity and propensity for bleeding is a part of the nature and clinical course of GIST, standard practices and procedures for the monitoring and management of haemorrhage in all patients should be applied.
Slovenian: Ker sta povečana vaskularnost in nagnjenje h krvavitvam del narave in kliničnega poteka GIST, je treba pri vseh bolnikih uporabiti standardne prakse in postopke za spremljanje in zdravljenje krvavitev.
English: Importantly, 27.7% of patients also achieved a major cytogenetic response, which was complete in 20.4% (confirmed 16%) of patients.
Slovenian: Pri tem je pomembno, da je 27,7 % bolnikov doseglo tudi pomemben citogenetični odziv, ki je bil pri 20,4 % bolnikov popoln (potrjen pri 16 %).
English: Major cytogenetic response Complete (Confirmed
Slovenian: Pomemben citogenetični odziv popoln (potrjen
English: What Imatinib Accord is and what it is used for What you need to know before you take Imatinib Accord How to take Imatinib Accord Possible side effects
Slovenian: Kaj je zdravilo Imatinib Accord in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Imatinib Accord Kako jemati zdravilo Imatinib Accord Možni neželeni učinki
English: 5 patients responded, 3 completely and 2 partially.
Slovenian: Do odziva je prišlo pri 5 bolnikih, pri 3 do popolnega in pri 2 do delnega.
English: Accord Healthcare Limited Sage House, 319 Pinner Road North Harrow
Slovenian: Sage House, 319 Pinner Road North Harrow,
English: While you are taking Imatinib Accord, your doctor will regularly check whether the medicine is working.
Slovenian: Med jemanjem zdravila Imatinib Accord bo zdravnik redno spremljal, ali zdravilo deluje.
English: Study 0109 40.5-month data Accelerated phase (n=235)
Slovenian: Študija 0109 podatki pri 40,5 meseca pospešena faza (n=235)
English: However, some of these reactions may be serious or life-threatening and several patients with blast crisis died with a complex clinical history of pleural effusion, congestive heart failure and renal failure.
Slovenian: Vendar so nekatere od teh reakcij lahko resne ali smrtno nevarne.Več bolnikov z blastno krizo je namreč umrlo z zapleteno klinično anamnezo plevralnega izliva, kongestivnega popuščanja srca in ledvične odpovedi.
English: A further 6DFSP patients treated with imatinib were reported in 5 published case reports, their ages ranging from 18 months to 49 years.
Slovenian: Nadaljnjih 6 bolnikov z DFSP, zdravljenih z imatinibom, so opisali v 5 publikacijah opisov primera, njihova starost se je gibala med 18 meseci in 49 leti.
English: Imatinib Accord will only be prescribed to you by a doctor with experience in medicines to treat blood cancers or solid tumours.
Slovenian: Zdravilo Imatinib Accord vam lahko predpiše samo zdravnik, ki ima izkušnje z zdravili za zdravljenje krvnih rakov in solidnih tumorjev.
English: The rate ofresponse was also higher in the patients treated at 600 mg (33%) as compared to the patients treated at 400 mg (16%, p=0.0220).
Slovenian: Stopnja odziva je bila tudi večja pri bolnikih, zdravljenih s 600 mg (33 %), kot pri bolnikih, zdravljenih s 400 mg (16 %, p=0,0220).
English: In this study 65% of the patients achieved a major cytogenetic response that was complete in 53% (confirmed 43%) of patients (Table 3).
Slovenian: V tej študiji je 65 % bolnikov doseglo pomemben citogenetični odziv, ki je bil popoln pri 53 % (potrjen pri 43 %) bolnikov (preglednica 3).
English: Because of known increased risks of bleeding in conjunction with the use of imatinib (e.g. haemorrhage), patients who require anticoagulation should receive low-molecular-weight or standard heparin, instead of coumarin derivatives such as warfarin.
Slovenian: Zaradi znanega povečanega tveganja za krvavitve v povezavi z uporabo imatiniba (na primer hemoragija) naj bolniki, pri katerih je potrebna antikoagulantna terapija, dobivajo nizkomolekularni ali standardni heparin namesto kumarinskih derivatov, kot je varfarin.
English: • Do not use this medicine after the expiry date which is stated on the carton and blister after
Slovenian: • Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu poleg oznake “EXP”.
English: Women of childbearing potential must be advised to use effective contraception during treatment.
Slovenian: Ženske v rodni dobi Ženskam v rodni dobi je treba svetovati, naj med zdravljenjem uporabljajo učinkovito kontracepcijo.
English: In patients treated with metoprolol clinical monitoring should be considered.
Slovenian: Pri bolnikih, ki se zdravijo z metoprololom, je treba razmisliti o kliničnem nadzoru.
English: They may increase or decrease the effect of Imatinib Accord, either leading to increased side effects or making Imatinib Accord less effective.
Slovenian: Lahko povečajo ali zmanjšajo učinek zdravila Imatinib Accord in zato bodisi povečajo verjetnost za nastanek neželenih učinkov, bodisi zmanjšajo učinkovitost zdravila Imatinib Accord.
English: - If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Slovenian: Nosečnost, dojenje in plodnost - Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom, preden vzamete to zdravilo.
English: Imatinib did not interfere with the biotransformation of 5-fluorouracil, but it inhibited paclitaxel metabolism as a result of competitive inhibition of CYP2C8 (Ki = 34.7 μM).
Slovenian: Imatinib ni oviral biotransformacije 5-fluorouracila, je pa zaviral presnovo paklitaksela zaradi kompetitivne inhibicije CYP2C8 (Ki = 34,7 μM).
English: The percentage of some adverse reactions was higher in the 40 patients in whom the dose was increased to 800 mg daily compared to the population of patients before dose increase (n=551).
Slovenian: Odstotni delež nekaterih neželenih reakcij je bil večji pri tistih 40 bolnikih, pri katerih je bil odmerek zvečan na 800 mg na dan, kot pri populaciji bolnikov pred zvečanjem odmerka (n=551).
English: Pharmacokinetics in children and adolescents
Slovenian: Farmakokinetika pri otrocih in mladostnikih
English: Imatinib Accord inhibits the growth of these cells in a certain subtype of these diseases.
Slovenian: Zdravilo Imatinib Accord zavira rast teh celic pri določenih podskupinah teh bolezni.
English: If you are being treated for CML
Slovenian: - Če se zdravite zaradi KML
English: There is no experience in children with CML below 2 years of age and with Ph+ ALL below 1 year of age (see section 5.1).
Slovenian: Izkušenj pri otrocih s KML, mlajših od 2 let, in pri otrocih s Ph+ALL, mlajših od 1 leta, ni (glejte poglavje 5.1).
English: The doctor will tell you how many tablets of Imatinib Accord to give to your child.
Slovenian: Zdravnik vam bo povedal, koliko tablet zdravila Imatinib Accord dajte svojemu otroku.
English: 8 to 10 g (single dose): Vomiting and gastrointestinal pain have been reported.
Slovenian: Odmerki od 8 do 10 g (enkratni odmerki): Opisovali so bruhanje in bolečine v prebavilih.
English: This was a population of heavily pretreated patients, as 46% had received prior BMT and 73% a prior multi-agent chemotherapy.
Slovenian: To je bila skupina že prej močno zdravljenih bolnikov, saj jih je pred začetkom raziskave 46 % prejelo BMT, 73 % pa kemoterapijo z več zdravili.
English: The yearly rates of progression of any type for Imatinib also decreased over time.
Slovenian: Tudi letne stopnje kakršnegakoli napredovanja bolezni za zdravilo Imatinib Accord so se sčasoma zmanjševale.
English: If this applies to you, tell your doctor without taking Imatinib Accord.
Slovenian: Če to velja za vas, povejte zdravniku in ne jemljite zdravila Imatinib Accord.
English: The majority of patients who achieved a CCyR developed the CCyR between months 3 and 10 with a median time to response based on the Kaplan-Meier estimate of 5.6 months.
Slovenian: Večina bolnikov, ki je dosegla popolni citogenetični odziv, ga je dosegla med 3. in 10. mesecem s povprečnim časom do odziva 5,6 meseca glede na Kaplan-Meierjevo oceno.
English: Renal function should, therefore, be evaluated prior to the start of imatinib therapy and closely monitored during therapy, with particular attention to those patients exhibiting risk factors for renal dysfunction.
Slovenian: Zato je treba pred začetkom zdravljenja z imatinibom oceniti delovanje ledvic in ga med zdravljenjem natančno spremljati, še posebej pri tistih bolnikih, ki kažejo dejavnike tveganja za ledvično disfunkcijo.
English: Imatinib Accord is a medicine containing an active substance called imatinib.
Slovenian: Imatinib Accord je zdravilo, ki vsebuje zdravilno učinkovino z imenom imatinib.
English: Imatinib Accord inhibits the growth of these cells.
Slovenian: Zdravilo Imatinib Accord zavira rast teh celic.
English: Long-term treatment with imatinib may be associated with a clinically significant decline in renal function.
Slovenian: Dolgotrajno zdravljenje z imatinibom je lahko povezano s klinično pomembnim zmanjšanjem delovanja ledvic.
English: Imatinib and the N-demethyl metabolite together accounted for about 65% of the circulating radioactivity (AUC(0-48h)).
Slovenian: Imatinib in N-demetilirani presnovek sta skupaj prispevala okrog 65 % radioaktivnosti v krvi (AUC(048h)).