FrancophonIA/ELRC3.0 huggingface dataset:
English: Paresthesia, dizziness, peripheral neuropathy rare
Slovenian: Bolezni živčevja glavobol občasni parestezija, omotica, periferna nevropatija redki motnje spomina/izguba spomina redki
English: (see section 4.3).
Slovenian: (glejte poglavje 4.3).
English: Skin and subcutaneous tissue disorders
Slovenian: Bolezni kože in podkožja dermatitis in ekcem občasni
English: How to store Cholib
Slovenian: Shranjevanje zdravila Cholib
English: Asthenia rare
Slovenian: Jetrne bolezni
English: Respiratory, thoracic and mediastinal disorders
Slovenian: Bolezni dihal, prsnega koša in mediastinalnega prostora intersticijska pljučna bolezen neznana
English: The risk of myopathy and rhabdomyolysis is significantly increased by concomitant use of gemfibrozil with simvastatin.
Slovenian: Pri sočasni uporabi gemfibrozila in simvastatina se pomembno poveča tveganje za miopatijo in rabdomiolizo.
English: Hypersensitivity syndrome rare
Slovenian: Preobčutljivostni sindrom
English: Simvastatin is well absorbed and undergoes extensive hepatic first-pass extraction.
Slovenian: V jetrih poteka obsežna ekstrakcija prvega prehoda.
English: In patients taking products containing elbasvir or grazoprevir concomitantly with Cholib the dose of simvastatin should not exceed 20 mg/day.
Slovenian: Zato pri bolnikih, ki jemljejo amiodaron, amlodipin, diltiazem ali verapamil, odmerek zdravila Cholib ne sme preseči 145 mg/20 mg na dan.
English: Contraindicated with Cholib 145 mg/40 mg
Slovenian: Kontraindicirani z zdravilom Cholib 145 mg/40 mg.
English: • If you are already taking the following medicines: o danazol (a man-made hormone used to treat endometriosis) o ciclosporin (a medicine often used in organ transplant patients) o itraconazole, ketoconazole, fluconazole or posaconazole (medicines for fungal infections) o HIV protease inhibitors such as indinavir, nelfinavir, ritonavir and saquinavir (medicines used for HIV infection and AIDS) o erythromycin, clarithromycin, or telithromycin (medicines for bacterial infections) o nefazodone (a medicine for depression) o amiodarone (a medicine for an irregular heartbeat) or verapamil (a medicine for high blood pressure, chest pain associated with heart disease, or other heart conditions) o hepatitis C antiviral agents such as elbasvir, grazoprevir, glecaprevir or pibrentasvir (used to treat hepatitis C virus infection)
Slovenian: • če že jemljete naslednja zdravila:  danazol (umetno izdelan hormon za zdravljenje endometrioze),  ciklosporin (zdravilo, ki ga uporabljajo po presaditvah organov),  itrakonazol, ketokonazol, flukonazol ali posakonazol (zdravila za glivične okužbe),  zaviralce proteaze HIV, kot so indinavir, nelfinavir, ritonavir in sakvinavir (zdravila za okužbo z virusom HIV in za AIDS),  eritromicin, klaritromicin ali telitromicin (zdravila za bakterijske okužbe),  nefazodon (zdravilo za depresijo),  amiodaron (zdravilo za nereden srčni utrip) ali verapamil (zdravilo za visok krvni tlak, bolečine v prsnem košu, povezane s srčno boleznijo, ali druge srčne bolezni),  protivirusne učinkovine proti hepatitisu C, kot so elbasvir, grazoprevir, glekaprevir ali pibrentasvir (zdravila za zdravljenje okužbe z virusom hepatitisa C);
English: • If you are already taking the following medicines: o danazol (a man-made hormone used to treat endometriosis) o ciclosporin (a medicine often used in organ transplant patients) o itraconazole, ketoconazole, fluconazole or posaconazole (medicines for fungal infections) o HIV protease inhibitors such as indinavir, nelfinavir, ritonavir and saquinavir (medicines used for HIV infection and AIDS) o glecaprevir or pibrentasvir (used to treat hepatitis C virus infection) o erythromycin, clarithromycin, or telithromycin (medicines for bacterial infections) o nefazodone (a medicine for depression)
Slovenian: • če že jemljete naslednja zdravila:  danazol (umetno izdelan hormon za zdravljenje endometrioze),  ciklosporin (zdravilo, ki ga uporabljajo po presaditvah organov),  itrakonazol, ketokonazol, flukonazol ali posakonazol (zdravila za glivične okužbe),  zaviralce proteaze HIV, kot so indinavir, nelfinavir, ritonavir in sakvinavir (zdravila za okužbo z virusom HIV in za AIDS),  glekaprevir ali pibrentasvir (zdravili za zdravljenje okužbe z virusom hepatitisa C),  eritromicin, klaritromicin ali telitromicin (zdravila za bakterijske okužbe),  nefazodon (zdravilo za depresijo);
English: Sexual dysfunction uncommon
Slovenian: Motnje reprodukcije in dojk spolna disfunkcija občasni erektilna disfunkcija neznana
English: One film-coated tablet contains 145 mg of fenofibrate and 20 mg of simvastatin.
Slovenian: Ena filmsko obložena tableta vsebuje 145 mg fenofibrata in 20 mg simvastatina.
English: Poly (vinyl alcohol), partially hydrolysed (E1203), titanium dioxide (E171), talc (E553b), lecithin (derived from soya bean (E322)), xanthan gum (E415), iron oxide red (E172).
Slovenian: polivinilalkohol, delno hidroliziran (E1203), titanov dioksid (E171), smukec (E553b), lecitin (sojin (E322)), ksantanski gumi (E415), rdeči železov oksid (E172).
English: Non-HDL-C (mmol/L)
Slovenian: Ne-HDL-holesterol (mmol/l)
English: The geometric mean ratios and 90% CIs for the comparison of AUC, AUC(0-t) and Cmax for fenofibric acid, simvastatin and simvastatin acid of the fixed dose combination Cholib 145 mg/40 mg tablet and the co-administration of the separate 145 mg fenofibrate and 40 mg simvastatin tablets as used in the clinical program, were all within the 80-125% bioequivalence interval.
Slovenian: Razmerja geometričnih sredin in 90-odstotni intervali zaupanja primerjave AUC, AUC(0-t) in Cmax fenofibrinske kisline, simvastatina in simvastatinske kisline pri fiksni kombinaciji odmerkov v zdravilu Cholib 145 mg/40 mg tablete in pri sočasni uporabi ločenih tablet fenofibrata 145 mg in simvastatina 40 mg v kliničnem programu so bili znotraj 80- do 125-odstotnega bioekvivalenčnega intervala.
English: Rash, pruritus, urticaria)
Slovenian: neznana kožna preobčutljivost (npr. izpuščaj, pruritus, urtikarija)
English: Effects on the pharmacokinetics of other medicinal products Fenofibrate and simvastatin are not CYP 3A4 inhibitors or inducers.
Slovenian: Fenofibrat in simvastatin nista zaviralca ali induktorja CYP 3A4.
English: o danazol (a man-made hormone used to treat endometriosis) o ciclosporin (a medicine often used in organ transplant patients) o itraconazole, ketoconazole, fluconazole or posaconazole (medicines for fungal infections) o HIV protease inhibitors such as indinavir, nelfinavir, ritonavir and saquinavir (medicines used for HIV infection and AIDS) o glecaprevir or pibrentasvir (used to treat hepatitis C virus infection) o erythromycin, clarithromycin, or telithromycin (medicines for bacterial infections) o nefazodone (a medicine for depression) o a fibrate (e.g. fenofibrate, gemfibrozil) o a statin (e.g. simvastatin, atorvastatin)
Slovenian:  danazol (umetno izdelan hormon za zdravljenje endometrioze),  ciklosporin (zdravilo, ki ga uporabljajo po presaditvah organov),  itrakonazol, ketokonazol, flukonazol ali posakonazol (zdravila za glivične okužbe),  zaviralce proteaze HIV, kot so indinavir, nelfinavir, ritonavir in sakvinavir (zdravila za okužbo z virusom HIV in za AIDS),  glekaprevir ali pibrentasvir (zdravili za zdravljenje okužbe z virusom hepatitisa C),  eritromicin, klaritromicin ali telitromicin (zdravila za bakterijske okužbe),  nefazodon (zdravilo za depresijo),  fibrat (npr. fenofibrat, gemfibrozil),  statin (npr. simvastatin, atorvastatin),
English: The geometric mean ratios and 90% CIs for the comparison of AUC, AUC(0-t) and Cmax of the active metabolites, fenofibric acid and simvastatin acid, of the fixed dose combination Cholib 145 mg/20 mg tablet and the co-administration of the separate 145 mg fenofibrate and 20 mg simvastatin tablets as used in the clinical program, were all within the 80-125% bioequivalence interval.
Slovenian: Razmerja geometričnih sredin in 90-odstotni intervali zaupanja primerjave AUC, AUC(0-t) in Cmax aktivnih presnovkov, fenofibrinske kisline in simvastatinske kisline, pri fiksni kombinaciji odmerkov v zdravilu Cholib 145 mg/20 mg tablete in pri sočasni uporabi ločenih tablet fenofibrata 145 mg in simvastatina 20 mg v kliničnem programu so bili znotraj 80- do 125-odstotnega bioekvivalenčnega intervala.
English: Cholib 145 mg/20 mg film-coated tablets
Slovenian: Cholib 145 mg/20 mg filmsko obložene tablete
English: CYP 3A4 inhibitors: fluconazole, verapamil, or diltiazem (see sections 4.3 and 4.4).
Slovenian: Previdnost je potrebna pri kombiniranju zdravila Cholib in določenih drugih manj močnih zaviralcev CYP 3A4: flukonazol, verapamil ali diltiazem (glejte poglavja 4.3 in 4.4).
English: Cholib 145 mg/40 mg film-coated tablets
Slovenian: Cholib 145 mg/40 mg filmsko obložene tablete
English: The geometric mean ratios and 90% CIs for the comparison of plasma exposure (AUC and AUC(0-t)) to simvastatin after administration of the fixed dose combination Cholib 145 mg/20 mg tablet and after co-administration of the separate 145 mg fenofibrate and 20 mg simvastatin tablets as used in the clinical program, were within the 80-125% bioequivalence interval.
Slovenian: Razmerja geometrijčnih sredin in 90-odstotni intervali zaupanja primerjave plazemske izpostavljenosti (AUC in AUC (0-t)) simvastatinu pri uporabi fiksne kombinacije odmerkov v zdravilu Cholib 145 mg/20 mg tablete in pri sočasni uporabi ločenih tablet fenofibrata 145 mg in simvastatina 20 mg v kliničnem programu so bili znotraj 80- do 125-odstotnega bioekvivalenčnega intervala.
English: Haemoglobin decreased White blood cell count decreased rare
Slovenian: Bolezni krvi in limfatičnega sistema znižana raven hemoglobina zmanjšano število levkocitov redki anemija redki
English: HDL-C (mmol/L)
Slovenian: HDL-holesterol (mmol/l)
English: Cholib 145 mg/40 mg tablets fenofibrate/simvastatin
Slovenian: Cholib 145 mg/40 mg tablete fenofibrat/simvastatin
English: Cholib 145 mg/20 mg tablets fenofibrate/simvastatin
Slovenian: Cholib 145 mg/20 mg tablete fenofibrat/simvastatin
English: Skeletal muscle toxicity, including rare cases of rhabdomyolysis with or without renal failure, has been reported with administration of lipid-lowering substances like fibrates and statins.
Slovenian: Po dajanju učinkovin za nižanje ravni lipidov, kot so fibrati in statini, so zabeležili primere toksičnosti za skeletne mišice, vključno z redkimi primeri rabdomiolize z ledvično odpovedjo in brez nje.
English: Simvastatin, which is an inactive lactone, is hydrolyzed in the liver to the corresponding active beta-hydroxyacid form which has a potent activity in inhibiting HMG-CoA reductase
Slovenian: Simvastatin je neaktiven lakton, ki se in vivo hitro hidrolizira v ustrezno betahidroksi kislino, ki močno zavira reduktazo HMG-CoA. Hidroliza v glavnem poteka v jetrih, hidroliza v človeški plazmi pa je zelo počasna.
English: Poly (vinyl alcohol), partially hydrolysed (E1203), titanium dioxide (E171), talc (E553b), lecithin (derived from soya bean (E322)), xanthan gum (E415), iron oxide red (E172), iron oxide yellow (E172), sunset yellow FCF (E110).
Slovenian: Filmska obloga: delno hidroliziran polivinilalkohol (E1203), titanov dioksid (E171), smukec (E553b), lecitin (sojin (E322)), ksantanski gumi (E415), rdeči železov oksid (E172), rumeni železov oksid (E172), barvilo sončno rumeno FCF (E110).
English: Hepatobiliary disorders Transaminases increased common
Slovenian: Bolezni krvi in limfatičnega sistema zvišano število trombocitov pogosti
English: Lecithin (derived from soya bean (E322)) Xanthan gum (E415) Iron oxide red (E172) Iron oxide yellow (E172) Sunset yellow FCF (E110)
Slovenian: smukec (E553b), lecitin (sojin (E322)), ksantanski gumi (E415), rdeči železov oksid (E172), rumeni železov oksid (E172), sončno rumeno FCF (E110).
English: 0.3% of patients receiving co-administration had clinically relevant increases in creatinine to values >200 µmol/l.
Slovenian: Klinično pomembno zvišanje ravni kreatinina nad > 200 μmol/l je imelo 0,3 % bolnikov, ki so sočasno prejemali obe zdravili.
English: In the larger study a reduction of 21% (90% CI 14%-27%) in AUC of SVA was observed after repeated co-administration of simvastatin 40 mg and fenofibrate 145 mg in the evening.
Slovenian: V večji študiji so po večkratnem sočasnem dajanju simvastatina 40 mg in fenofibrata 145 mg zvečer opazili 21-odstotno zmanjšanje AUC SVK (90-odstotni IZ 14 %-27 %).
English: Telithromycin
Slovenian: Telitromicin
English: The film-coated tablet (tablet) is a, oval, biconvex, brick red coloured 19.3 x 9.3 mm tablet with bevelled edges and the inscription 145/40 on one side and the Abbott logo on the other side.
Slovenian: Filmsko obložena tableta (tableta) je ovalna, bikonveksna, opečnato rdeče obarvana tableta velikosti 19,3 x 9,3 mm s posnetimi robovi in napisom 145/40 na eni strani in logotipom podjetja Abbott na drugi strani.
English: Increases in transaminase levels have been reported in some patients treated with simvastatin or fenofibrate.
Slovenian: Pri nekaterih bolnikih, zdravljenih s simvastatinom ali fenofibratom, so ugotovili zvišane ravni transaminaz.
English: Diabetes Mellitus**** not known
Slovenian: Presnovne in prehranske motnje sladkorna bolezen****
English: The film-coated tablet (tablet) is a, oval, biconvex, tan coloured 19.3 x 9.3 mm tablet with bevelled edges and the inscription 145/20 on one side and the Abbott logo on the other side.
Slovenian: Filmsko obložena tableta (tableta) je ovalna, bikonveksna, bež obarvana tableta velikosti 19,3 x 9,3 mm s posnetimi robovi in napisom 145/20 na eni strani in logotipom podjetja Abbott na drugi strani.
English: Cholib 145 mg/20 mg film-coated tablets fenofibrate/simvastatin
Slovenian: Cholib 145 mg/20 mg filmsko obložene tablete fenofibrat/simvastatin
English: Cholib 145 mg/40 mg film-coated tablets fenofibrate/simvastatin
Slovenian: Cholib 145 mg/40 mg filmsko obložene tablete fenofibrat/simvastatin
English: Each tablet contains 145 mg of fenofibrate and 40 mg of simvastatin
Slovenian: Ena tableta vsebuje 145 mg fenofibrata in 40 mg simvastatina
English: Alanine- aminotransferase increased
Slovenian: Bolezni jeter, žolčnika in žolčevodov zvišana raven alanin-aminotransferaze pogosti
English: Each tablet contains 145 mg of fenofibrate and 20 mg of simvastatin
Slovenian: Ena tableta vsebuje 145 mg fenofibrata in 20 mg simvastatina
English: Oval, biconvex, tan coloured, 19.3 x 9.3 mm film-coated tablet with bevelled edges and the inscription 145/20 on one side and the Abbott logo on the other side.
Slovenian: Ovalna, bikonveksna, bež filmsko obložena tableta velikosti 19,3 x 9,3 mm s posnetimi robovi in napisom 145/20 na eni strani in logotipom podjetja Abbott na drugi strani.
English: Each tablet contains 145 mg of fenofibrate and 40 mg of simvastatin.
Slovenian: Ena tableta vsebuje 145 mg fenofibrata in 40 mg simvastatina.
English: • increase in “urea” - produced by the kidneys - shown in tests
Slovenian: • zvišanje ravni „sečnine“ (snovi, ki jo tvorijo ledvice), kar pokažejo preiskave,
English: Oval, biconvex, brick red coloured, 19.3 x 9.3 mm film-coated tablet with bevelled edges and the inscription 145/40 on one side and the Abbott logo on the other side.
Slovenian: Ovalna, bikonveksna, opečno rdeča filmsko obložena tableta velikosti 19,3 x 9,3 mm s posnetimi robovi in napisom 145/40 na eni strani in logotipom podjetja Abbott na drugi strani.
English: Each tablet contains 145 mg of fenofibrate and 20 mg of simvastatin.
Slovenian: Ena tableta vsebuje 145 mg fenofibrata in 20 mg simvastatina.
English: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of ciclosporin with simvastatin.
Slovenian: Pri sočasni uporabi ciklosporina in simvastatina se poveča tveganje za miopatijo/rabdomiolizo.
English: One film-coated tablet contains 145 mg of fenofibrate and 40 mg of simvastatin.
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Ena filmsko obložena tableta vsebuje 145 mg fenofibrata in 40 mg simvastatina.
English: Interacting substances
Slovenian: SEZNAM POMOŽNIH SNOVI
English: The primary efficacy criterion was superiority of the combination fenofibrate 145 and simvastatin 20 mg versus simvastatin 40 mg on TG decrease and HDL-C increase and non-inferiority for LDL-C decrease at 12 weeks.
Slovenian: V študiji 0501 so v 24-tedenskem dvojno slepem obdobju vrednotili dva različna odmerka kombinacije fenofibrata in simvastatina v primerjavi s simvastatinom 40 mg. Primarno merilo učinkovitosti je bila boljša učinkovitost kombinacije fenofibrata 145 mg in simvastatina 20 mg v primerjavi s simvastatinom 40 mg pri znižanju TG in zvišanju HDL-holesterola ter neinferiornost pri znižanju LDL-holesterola po 12 tednih.
English: Your doctor should do a blood test before you start taking Cholib.
Slovenian: Pred začetkom jemanja zdravila Cholib boste morali opraviti krvno preiskavo, da vaš zdravnik preveri delovanje jeter.
English: The risk of myopathy and rhabdomyolysis is increased by concomitant administration of danazol with simvastatin.
Slovenian: Pri sočasni uporabi danazola in simvastatina se poveča tveganje za miopatijo in rabdomiolizo.
English: The risk of myopathy including rhabdomyolysis may be increased by the concomitant administration of systemic fusidic acid with statins.
Slovenian: Pri sočasni sistemski uporabi fusidne kisline in statinov se lahko poveča tveganje za miopatijo, vključno z rabdomiolizo.
English: uncommo n
Slovenian: n.r.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Brilique on 3 December 2010.
Slovenian: Evropska komisija je dovoljenje za promet z zdravilom Brilique, veljavno po vsej Evropski uniji, izdala 3. decembra 2010.
English: It is available as tablets (60 and 90 mg).
Slovenian: Na voljo je v obliki tablet (60 in 90 mg).
English: The full EPAR for Brilique can be searched for on the Agency's website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Brilique je na voljo na spletni strani agencije website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: Other information about Brilique
Slovenian: Druge informacije o zdravilu Brilique
English: It must also not be used in patients taking other medicines which have a strong blocking effect on one of the liver enzymes (CYP3A4).
Slovenian: Prav tako ga ne smejo uporabljati bolniki, ki jemljejo druga zdravila z močnim zaviralnim učinkom na enega od jetrnih encimov (CYP3A4).
English: The CHMP decided that Brilique's benefits are greater than its risks and recommended that it be given marketing authorisation.
Slovenian: CHMP je zaključil, da so koristi zdravila Brilique večje od z njim povezanih tveganj, in priporočil, da se zanj izda dovoljenje za promet.
English: For more information about treatment with Brilique, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Brilique preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: What is the risk associated with Brilique?
Slovenian: Kakšna tveganja so povezana z zdravilom Brilique?
English: This is a summary of the European public assessment report (EPAR) for Brilique.
Slovenian: Ta dokument je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Brilique.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Brilique.
Slovenian: Pojasnjuje, kako je Odbor za zdravila za uporabo v humani medicini (CHMP) ocenil to zdravilo, na podlagi česar je oblikoval mnenje za odobritev dovoljenja za promet z njim in priporočila glede pogojev njegove uporabe.
English: The patients also took aspirin and were treated for up to 3 years.
Slovenian: Bolniki so jemali tudi aspirin in so se zdravili največ tri leta.
English: What benefit has Brilique shown during the studies?
Slovenian: Kakšne koristi je zdravilo Brilique izkazalo med študijami?
English: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom taking Brilique should also be taking aspirin as directed by their doctor.
Slovenian: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom
English: Brilique must not be used in patients who have severe liver disease or are currently bleeding, or in patients who have had bleeding within the brain.
Slovenian: Zdravila Brilique ne smejo uporabljati bolniki s hudim obolenjem jeter ali ki trenutno krvavijo in bolniki, ki so imeli krvavitev v možganih.
English: Why has Brilique been approved?
Slovenian: Zakaj je bilo zdravilo Brilique odobreno?
English: The patients also took aspirin and were treated for up to a year.
Slovenian: Bolniki so jemali tudi aspirin in so se zdravili največ eno leto.
English: The doctor may, for health reasons, tell them not to take aspirin.
Slovenian: Zaradi zdravstvenih razlogov pa jim lahko zdravnik jemanje aspirina odsvetuje.
English: These are medicines such as ketoconazole (used to treat fungal infections), clarithromycin (an antibiotic), atazanavir and ritonavir (medicines used in HIV-positive patients) and nefazodone (used to treat depression).
Slovenian: To so zdravila, kot so ketokonazol (za zdravljenje glivičnih okužb), klaritromicin (antibiotik), atazanavir in ritonavir (zdravili za zdravljenje bolnikov, okuženih z virusom HIV) in nefazodon (za zdravljenje depresije).
English: Brilique is a medicine that contains the active substance ticagrelor.
Slovenian: Brilique je zdravilo, ki vsebuje zdravilno učinkovino ticagrelor.
English: Ticagrelor stops the platelets aggregating by blocking the action of a substance called ADP when it attaches to the surface of the platelets.
Slovenian: Ticagrelor prepreči agregacijo trombocitov tako, da zavira delovanje snovi, imenovane ADP, ko se pritrdi na površino trombocitov.
English: The main measure of effectiveness for both studies was based on the number of patients having another heart attack, a stroke or dying from a cardiovascular disease.
Slovenian: Glavno merilo učinkovitosti je pri obeh študijah temeljilo na številu bolnikov, ki so doživeli še en srčni infarkt ali kap oziroma so umrli zaradi srčno-žilne bolezni.
English: The most common side effects with Brilique (seen in more than 1 patient in 10) are dyspnoea (difficulty breathing), bleeding and raised uric acid level in the blood.
Slovenian: Najpogostejši neželeni učinki zdravila Brilique (opaženi pri več kot 1 bolniku od 10) so dispneja (težave z dihanjem), krvavitve in povečane ravni sečne kisline v krvi.
English: For longer treatment, the dose of Brilique should be reduced to one 60-mg tablet twice a day.
Slovenian: Pri daljšem zdravljenju je treba odmerek zdravila Brilique zmanjšati na eno 60-miligramsko tableto dvakrat na dan.
English: It is used in adults with acute coronary syndrome, a group of conditions in which blood flow in the vessels supplying the heart is blocked so heart tissue cannot work properly or dies, and which includes heart attack and unstable angina (a severe type of chest pain).
Slovenian: Uporablja se pri odraslih z akutnim koronarnim sindromom, tj. skupino obolenj, pri katerih je dotok krvi v žilah, ki oskrbujejo srce, zavrt, zaradi česar srčno tkivo ne more pravilno delovati ali odmre, in ki zajema srčni infarkt in nestabilno angino pektoris (hudo obliko bolečine v prsih).
English: Brilique is used together with aspirin (acetylsalicylic acid) to prevent atherothrombotic events (problems caused by blood clots and hardening of the arteries) such as heart attacks or strokes.
Slovenian: Zdravilo Brilique se uporablja skupaj z aspirinom (acetilsalicilno kislino) za preprečevanje aterotrombotičnih dogodkov (težav zaradi krvnih strdkov in zatrditve arterij), kot sta srčni infarkt ali kap.
English: This stops the platelets becoming ‘sticky', reducing the risk of a blood clot forming and helping to prevent a stroke or another heart attack.
Slovenian: Zaradi tega trombociti ne postanejo „lepljivi“, kar zmanjša tveganje za nastanek krvnega strdka in pripomore k preprečevanju kapi ali drugega srčnega infarkta.