FrancophonIA/ELRC3.0 huggingface dataset:
English: A boosted dose of 800 mg indinavir/100 mg ritonavir twice daily results in increased risk of adverse events.
Croatian: Pojačana doza od 800 mg indinavira/100 mg ritonavira dvaput na dan dovodi do povećanog rizika od nuspojava.
English: 3; and the mean increase in percent CD4 cell counts was 1.2 %.
Croatian: 3, a srednje povećanje udjela CD4 stanica iznosilo je 1,2%.
English: Talk to your doctor, pharmacist or nurse before taking CRIXIVAN if you have had or develop any of the following:
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete CRIXIVAN ako ste imali ili imate nešto od sljedećega:
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis carinii pneumonia.
Croatian: Relevantni primjeri su upala mrežnice uzrokovana citomegalovirusom, generalizirane i/ili fokalne infekcije mikobakterijama i pneumonija uzrokovana s Pneumocystis carinii.
English: Administration of indinavir with a meal high in calories, fat, and protein resulted in a blunted and reduced absorption with an approximate 80 % reduction in AUC and an 86 % reduction in Cmax.
Croatian: Primjena indinavira uz visokokaloričan obrok bogat mastima i proteinima otežala je i smanjila apsorpciju te smanjila AUC za približno 80%, a Cmax za približno 86%.
English: Ritonavir may induce glucuronidation of methadone.
Croatian: Ritonavir može inducirati glukuronidaciju metadona.
English: 3; and the mean increase in percent CD4 cell counts was 4.2 %.
Croatian: 3, a srednje povećanje udjela CD4 stanica bilo je 4,2%.
English: In patients at increased risk, urinary screening should be considered.
Croatian: U bolesnika u kojih postoji povećan rizik treba razmotriti provođenje pretraga mokraćnog sustava.
English: Complete cross resistance was noted between indinavir and ritonavir; however, cross resistance to saquinavir varied among isolates.
Croatian: Između indinavira i ritonavira opažena je potpuna križna rezistencija, međutim, križna rezistencija na sakvinavir razlikovala se među izolatima.
English: Renal clearance (116 mL/min) of indinavir is concentration-independent over the clinical dose range.
Croatian: Bubrežni klirens (116 ml/min) indinavira ne ovisi o koncentraciji kod doza iznad kliničkog raspona.
English: Based on an interaction study with lopinavir/ritonavir, combination of rosuvastatin and protease inhibitors is not recommended.
Croatian: Na temelju rezultata ispitivanja interakcija s lopinavirom/ritonavirom, ne preporučuje se kombinacija rosuvastatina i inhibitora proteaze.
English: No data has been obtained comparing rifabutin 150 mg QD in combination with indinavir 800 mg TID with a reference dose of 150 mg rifabutin alone)
Croatian: Nema podataka o usporedbi kombinacije rifabutina od 150 mg QD i indinavira od 800 mg TID s primjenom samo rifabutina u referentnoj dozi od 150 mg)
English: 90 hard capsules 180 hard capsules
Croatian: 90 tvrdih kapsula 180 tvrdih kapsula
English: If you forget to take CRIXIVAN
Croatian: Ako ste zaboravili uzeti CRIXIVAN
English: It is not known whether indinavir is excreted in human milk.
Croatian: Nije poznato izlučuje li se indinavir u majčino mlijeko.
English: Indinavir inhibits recombinant HIV-1 and HIV-2 protease with an approximate tenfold selectivity for HIV-1 over HIV-2 proteinase.
Croatian: Indinavir inhibira rekombinantnu HIV-1 i HIV-2 proteazu pri čemu je deseterotruko selektivniji za HIV-1 nego za HIV-2 proteinazu.
English: Similarly, effects on CD4 cell count tend to be more pronounced in patients treated with indinavir in combination with nucleoside analogues compared with indinavir alone.
Croatian: Slično tomu, učinci na broj CD4 stanica bili su izraženiji u bolesnika liječenih indinavirom u kombinaciji s nukleozidnim analozima nego u bolesnika liječenih samo indinavirom.
English: A normal (acidic) gastric pH may be necessary for optimum absorption of indinavir whereas acid rapidly degrades didanosine which is formulated with buffering agents to increase pH.
Croatian: Za optimalnu apsorpciju indinavira može biti potreban normalan (kiseli) želučani pH, ali kiselina brzo razgrađuje didanozin, kojemu se dodaju puferi koji povisuju pH.
English: • It is recommended that women with HIV do not breast-feed.
Croatian: • Preporučuje se da žene zaražene HIV-om ne doje.
English: Medical management in patients with one or more episodes of nephrolithiasis must include adequate hydration and may include temporary interruption of therapy (e.g., 1 to 3 days) during the acute episode of nephrolithiasis or discontinuation of therapy.
Croatian: Zbrinjavanje bolesnika s jednom ili više epizoda nefrolitijaze mora uključivati odgovarajuću hidrataciju, a može uključivati i privremeni prekid liječenja (npr. 1 do 3 dana) za vrijeme akutne faze nefrolitijaze ili pak potpuni prekid liječenja.
English: In one comparative trial, combination therapy with nucleoside analogues (triple therapy with zidovudine plus didanosine) conferred protection against the selection of virus expressing at least one resistanceassociated amino acid substitution to both indinavir (from 13/24 to 2/20 at therapy week 24) and to the nucleoside analogues (from 10/16 to 0/20 at therapy week 24).
Croatian: U jednom je usporednom ispitivanju kombinirano liječenje s nukleozidnim analozima (trojna terapija sa zidovudinom i didanozinom) pružilo zaštitu pred određenim virusima koji eksprimiraju barem jednu aminokiselinsku supstituciju povezanu s rezistencijom na indinavir (od 13/24 do 2/20 u 24. tjednu liječenja) i nukleozidne analoge (od 10/16 do 0/20 u 24. tjednu liječenja).
English: CRIXIVAN contains lactose
Croatian: CRIXIVAN sadrži laktozu
English: The pharmacokinetics of indinavir in these 11 patients at 6 weeks postpartum were generally similar to those observed in non-pregnant patients in another study (see section 4.6).
Croatian: U tih je 11 bolesnica 6 tjedana nakon poroda farmakokinetika indinavira u načelu bila podjednaka onoj opaženoj u bolesnica koje nisu bile trudne, a sudjelovale su u drugom ispitivanju (vidjeti dio 4.6).
English: • theophylline - used for asthma
Croatian: • teofilin - koristi se za astmu
English: Manufacturer: Merck Sharp & Dohme B.V., Waarderweg 39, Postbus 581, 2003 PC Haarlem The Netherlands
Croatian: Proizvođač: Merck Sharp & Dohme B.V., Waarderweg 39, Postbus 581, 2003 PC Haarlem, Nizozemska
English: In vitro studies with human liver microsomes indicated that CYP3A4 is the only P450 isozyme that plays a major role in the oxidative metabolism of indinavir.
Croatian: Ispitivanja in vitro na mikrosomima ljudske jetre pokazala su da je CYP3A4 jedini izoenzim P450 koji igra veliku ulogu u oksidativnom metabolizmu indinavira.
English: • delavirdine, efavirenz, nevirapine - used for HIV
Croatian: • delavirdin, efavirenz, nevirapin - koriste se za HIV infekciju
English: Indinavir should be used cautiously with other medicinal products that are potent inducers of CYP3A4.
Croatian: Indinavir se mora primjenjivati uz oprez s drugim lijekovima koji su snažni induktori CYP3A4.
English: • itraconazole, ketoconazole - used to treat fungal infections
Croatian: • itrakonazol, ketokonazol - koriste se za liječenje gljivičnih infekcija
English: • buspirone - used to make you calmer
Croatian: • buspiron - koristi se za umirenje
English: • morphine, fentanyl - used for pain
Croatian: • morfij, fentanil - koriste se za ublažavanje boli
English: This is to stop HIV being passed on to their baby.
Croatian: Time se sprječava prijenos HIV-a s majke na dijete.
English:  indinavir plasma concentrations may be expected (CYP3A induction).
Croatian: Može se očekivati  koncentracija indinavira u plazmi (indukcija CYP3A).
English: When CRIXIVAN is used with ritonavir, consult the Summary of Product Characteristics of ritonavir for additional contraindications.
Croatian: Kada se CRIXIVAN primjenjuje s ritonavirom, treba pročitati Sažetak opisa svojstava lijeka za ritonavir zbog dodatnih kontraindikacija.
English: Patients with severe hepatic impairment have not been studied.
Croatian: Bolesnici s teškim oštećenjem funkcije jetre nisu ispitivani.
English: CRIXIVAN is not a cure for HIV.
Croatian: CRIXIVAN neće izliječiti HIV infekciju.
English: HMG-CoA REDUCTASE INHIBITORS
Croatian: INHIBITORI HMG-CoA REDUKTAZE
English: Indinavir at concentrations of 25 to 100 nM mediated 95 % inhibition of viral spread in cultures of mitogen-activated human peripheral blood mononuclear cells infected with diverse, primary clinical isolates of HIV 1, including isolates resistant to zidovudine and nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Croatian: Indinavir je pri koncentracijama od 25 do 100 nM doveo do 95%-tne inhibicije širenja virusa u kulturama mitogenom aktiviranih mononuklearnih stanica iz ljudske periferne krvi, zaraženih različitim, prvenstveno kliničkim izolatima HIV 1, uključujući izolate rezistentne na zidovudin i nenukleozidne inhibitore reverzne transkriptaze.
English: HIV 1 patient isolates with reduced susceptibility to indinavir expressed varying patterns and degrees of cross-resistance to a series of diverse HIV PIs, including ritonavir and saquinavir.
Croatian: Na izolatima bolesnika zaraženih s HIV 1 sa smanjenom osjetljivošću na indinavir utvrđeni su različiti uzorci i stupnjevi križne rezistencije na niz različitih inhibitora HIV proteaze, uključujući ritonavir i sakvinavir.
English: • ingrown toenails with or without infection
Croatian: • urasli nokti na nožnim prstima, s infekcijom ili bez nje
English: The inducing effect may persist up to 2 weeks after cessation of treatment with St. John's wort.
Croatian: Indukcijski učinak može potrajati do 2 tjedna nakon prekida liječenja Gospinom travom.
English: Phenytoin may decrease serum levels of ritonavir.
Croatian: Fenitoin može smanjiti koncentracije ritonavira u serumu.
English: By intent to treat analysis 65 % of patients had HIV RNA < 400 copies/mL and 50 % had viral load < 50 copies/mL; by on-treatment analysis 96 % of patients had HIV RNA < 400 copies/mL and 74 % had viral load < 50 copies/mL.
Croatian: Kod analize populacije koju se namjeravalo liječiti, u 65% bolesnika vrijednost HIV RNK bila je < 400 kopija/ml, a u 50% je virusno opterećenje bilo < 50 kopija/ml; kod analize populacije koja je primala lijek, u 96% bolesnika vrijednost HIV RNK bila je < 400 kopija/ml, a u njih 74% je virusno opterećenje bilo < 50 kopija/ml.
English: If you notice any of these signs, talk to your doctor.
Croatian: Ako primijetite neke od tih simptoma, obavijestite svog liječnika.
English: No external or visceral changes were observed in rats, however, increases in the incidence of supernumerary ribs and of cervical ribs were seen.
Croatian: U štakora nisu primijećene promjene u vanjskom izgledu kao ni promjene na unutarnjim organima, ali je zabilježen porast incidencije prekobrojnih rebara i cervikalnih rebara.
English: Anti-Mycobacterial Rifabutin
Croatian: Antimikobakterijski lijekovi Rifabutin
English: Among patients experiencing viral RNA rebound during indinavir monotherapy at 800 mg q8h, substitutions at only three of these sites were observed in the majority of patients: V82 (to A or F), M46 (to I or L), and L10 (to I or R).
Croatian: Među većinom bolesnika, u kojih je tijekom monoterapije indinavirom u dozi od 800 mg svakih 8 sati došlo do ponovne aktivacije virusne RNK, primijećene su supstitucije na samo tri mjesta: V82 (na A ili F), M46 (na I ili L) i L10 (na I ili R).
English: In clinical trials in paediatric patients (≥ 3 years), the adverse reaction profile was similar to that for adult patients except for a higher frequency of nephrolithiasis of 29 % (20/70) in paediatric patients treated with CRIXIVAN.
Croatian: U kliničkim ispitivanjima s pedijatrijskim bolesnicima (≥ 3 godine) profil nuspojava bio je sličan onome u odraslih bolesnika, izuzev više incidencije nefrolitijaze, koja je u pedijatrijskih bolesnika liječenih lijekom CRIXIVAN iznosila 29% (20/70).
English: Thirty subjects completed 48 weeks of treatment.
Croatian: Liječenje u trajanju od 48 tjedana završilo je 30 ispitanika.
English: However, patients should be informed that dizziness and blurred vision have been reported during treatment with indinavir.
Croatian: Ipak, bolesnike treba upozoriti da su tijekom liječenja indinavirom prijavljene omaglica i zamagljen vid.
English: Concomitant administration of indinavir and quetiapine may increase plasma concentrations of quetiapine leading to quetiapine-related toxicity, including coma.
Croatian: Istodobna primjena indinavira i kvetiapina može povisiti koncentracije kvetiapina u plazmi što može dovesti do toksičnosti povezane s kvetiapinom, uključujući komu.
English: IMMUNOSUPPRESSIVES Cyclosporine A
Croatian: Ciklosporin A
English: Zidovudine AUC:  Zidovudine Cmin: ↑ 51 %
Croatian: AUC zidovudina:  Cmin zidovudina: ↑ 51%
English: In rats, at similar exposure levels, an increased incidence of thyroid adenomas was seen, probably related to an increase in release of thyroid stimulating hormone secondary to an increase in thyroxine clearance.
Croatian: U štakora je kod slične razine izloženosti zabilježena povećana incidencija adenoma štitnjače, koja je vjerojatno povezana s pojačanim otpuštanjem tireostimulirajućeg hormona kao posljedice povećanja klirensa tiroksina.
English: Seven major metabolites were identified and the metabolic pathways were identified as glucuronidation at the pyridine nitrogen, pyridine-N-oxidation with and without 3'-hydroxylation on the indane ring, 3'-hydroxylation of indane, p-hydroxylation of phenylmethyl moiety, and N-depyridomethylation with and without the 3'-hydroxylation.
Croatian: Otkriveno je sedam glavnih metabolita, a utvrđeni metabolički putevi su glukuronidacija na piridinskom dušiku, oksidacija piridinskog dušika s 3'-hidroksilacijom na indanskom prstenu ili bez nje, 3'-hidroksilacija indana, p-hidroksilacija fenilmetilne skupine i N-depiridometilacija s 3'-hidroksilacijom ili bez nje.
English: The bottle contains desiccant canisters that should remain in the bottle.
Croatian: Bočica sadrži spremnike sa sredstvom za sušenje koji moraju ostati u bočici.
English: In general, these events were not associated with renal dysfunction and resolved with hydration and temporary interruption of therapy (e.g., 1-3 days).
Croatian: Navedeni događaji u načelu nisu bili povezani s poremećajem funkcije bubrega, a povukli su se nakon hidratacije i privremenog prekida liječenja (npr. 1-3 dana).
English: • ritonavir - 100 mg - taken twice a day.
Croatian: • ritonavir - 100 mg - dvaput na dan.
English: The bottles contain desiccant canisters that should remain in the container.
Croatian: Bočice sadrže spremnike sa sredstvom za sušenje koji moraju ostati u bočici.
English: Alternatively, CRIXIVAN may be administered with a low-fat, light meal.
Croatian: Alternativno se CRIXIVAN može uzeti uz lagan obrok siromašan mastima.
English: Also look at the Package Leaflet for ritonavir.
Croatian: Također pročitajte Uputu o lijeku za ritonavir.
English: The concomitant use of indinavir with nucleoside analogues (to which the patient is naive) may lessen the risk of the development of resistance to both indinavir and the nucleoside analogues.
Croatian: Istodobna primjena indinavira s nukleozidnim analozima (kojima bolesnik prethodno nije bio liječen) može umanjiti rizik od razvoja rezistencije na indinavir i nukleozidne analoge.
English: Method of administration The hard capsules should be swallowed whole.
Croatian: Način primjene Tvrde kapsule treba progutati cijele.
English: Posology The recommended dose of indinavir is 800 mg orally every 8 hours.
Croatian: Doziranje Preporučena doza indinavira je 800 mg peroralno svakih 8 sati.
English: Indinavir at concentrations of 50 to 100 nM mediated 95 % inhibition (IC95) of viral spread (relative to an untreated virus-infected control) in human T-lymphoid cell cultures and primary human monocytes/macrophages infected with HIV 1 variants LAI, MN, RF, and a macrophage-tropic variant SF-162, respectively.
Croatian: Indinavir je pri koncentracijama od 50 do 100 nM doveo do 95%-tne inhibicije (IC95) širenja virusa (u usporedbi s neliječenom skupinom zaraženom virusom) u kulturama humanih T-limfoidnih stanica i primarnim humanim monocitima/makrofagima zaraženim varijantama HIV 1: LAI, MN, RF odnosno makrofagotropnom varijantom SF-162.
English: The following effects may happen:
Croatian: Može se javiti sljedeće:
English: This is because these foods stop your body being able to take in as much CRIXIVAN and it will not work as well.
Croatian: Naime, takva hrana tijelu onemogućuje da preuzme dovoljnu količinu lijeka CRIXIVAN i stoga lijek neće djelovati dovoljno dobro.
English: If CRIXIVAN is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Croatian: Ako se CRIXIVAN primjenjuje istodobno s parenteralnim midazolamom, treba ga primijeniti u jedinici intenzivne skrbi uz poman klinički nadzor u slučaju respiratorne depresije i/ili prolongirane sedacije.
English: In one published study, 20 HIV-infected patients with undetectable plasma viral load (< 200 copies/mL) receiving indinavir 800 mg every 8 hours were switched in an open, cross-over design to indinavir/ritonavir 400/100 mg every 12 hours.
Croatian: U jednom je objavljenom ispitivanju 20 bolesnika zaraženih HIV-om s nemjerljivim virusnim opterećenjem u plazmi (< 200 kopija/ml) koji su primali indinavir u dozi od 800 mg svakih 8 sati u sklopu otvorenog, ukriženog ispitivanja prebačeno na liječenje indinavirom/ritonavirom u dozi od 400/100 mg svakih 12 sati.
English: There have been reports of human overdose with CRIXIVAN.
Croatian: Prijavljeni su slučajevi predoziranja lijekom CRIXIVAN u ljudi.
English: Nephrolithiasis, including flank pain with or without haematuria (including microscopic haematuria), has been reported in approximately 10 % (252/2,577) of patients receiving CRIXIVAN in clinical trials at the recommended dose compared to 2.2 % in the control arms.
Croatian: Nefrolitijaza, uključujući bol u slabinama koja može, ali i ne mora biti praćena hematurijom (uključujući mikroskopsku hematuriju), prijavljena je u otprilike 10% (252/2577) bolesnika liječenih u sklopu kliničkih ispitivanja preporučenom dozom lijeka CRIXIVAN u odnosu na 2,2% ispitanika u kontrolnoj skupini.
English: Capsule content anhydrous lactose magnesium stearate
Croatian: Sadržaj kapsule: laktoza, bezvodna magnezijev stearat
English: In zidovudine experienced patients, indinavir, zidovudine and lamivudine in combination compared with lamivudine added to zidovudine reduced the probability of AIDS defining illness or death (ADID) at 48 weeks from 13 % to 7 %.
Croatian: U bolesnika prethodno liječenih zidovudinom je kombinacija indinavira, zidovudina i lamivudina u usporedbi s lamivudinom kao dodatkom zidovudinu smanjila vjerojatnost pojave bolesti ili smrti povezane s AIDS-om s 13% na 7% u 48. tjednu.
English: With the exception of dry skin, rash, and taste perversion, the incidence of clinical adverse reactions was similar or higher among patients treated with antiretroviral nucleoside analogue controls than among patients treated with CRIXIVAN monotherapy or in combination with NRTI(s).
Croatian: Uz izuzetak suhe kože, osipa i promjene osjeta okusa, incidencija kliničkih nuspojava bila je podjednaka ili viša u bolesnika liječenih kontrolno antiretrovirusnim nukleozidnim analozima nego u bolesnika liječenih lijekom CRIXIVAN u monoterapiji ili u kombinaciji s jednim ili više NRTI-ja.
English: The following side effects have been reported by patients taking CRIXIVAN:
Croatian: Bolesnici koji uzimaju CRIXIVAN prijavili su sljedeće nuspojave:
English: Boosted indinavir (indinavir with ritonavir) may have additive pharmacokinetic effects on substances that share the CYP3A4 pathway as both ritonavir and indinavir inhibit the cytochrome P450 enzyme CYP3A4.
Croatian: Pojačani indinavir (indinavir s ritonavirom) može imati aditivni farmakokinetički učinak na tvari koje se metaboliziraju posredstvom CYP3A4 jer i ritonavir i indinavir inhibiraju enzim CYP3A4 citokroma P450.
English: If CRIXIVAN with ritonavir is coadministered with parenteral midazolam, it should be done in an intensive care unit with close clinical monitoring in case of respiratory depression and/or prolonged sedation.
Croatian: Ako se CRIXIVAN s ritonavirom primjenjuje istodobno s parenteralnim midazolamom, to treba provoditi u jedinici intenzivne skrbi uz poman klinički nadzor u slučaju respiratorne depresije i/ili prolongirane sedacije.
English: • amprenavir, saquinavir, atazanavir - used for HIV
Croatian: • amprenavir, sakvinavir, atazanavir - koriste se za HIV infekciju
English: Indinavir and norethindrone/ethinyl estradiol 1/35 can be coadministered without dose adjustment.
Croatian: Indinavir i noretindron/etinilestradiol 1/35 mogu se primijeniti istodobno bez prilagođavanja doze.
English: Calcium channel blockers are metabolized by CYP3A4 which is inhibited by indinavir.
Croatian: Blokatore kalcijevih kanala metabolizira CYP3A4, a njega inhibira indinavir.
English: Ritonavir may increase digoxin levels due to modification of P-glycoprotein mediated digoxin efflux.
Croatian: Ritonavir može povećati koncentracije digoksina zahvaljujući promjenama u efluksu digoksina uzrokovanim P-glikoproteinom.
English: Preliminary clinical data suggest that CRIXIVAN 400 mg in combination with ritonavir 100 mg, both administered orally twice daily, may be an alternative dosing regimen (see section 5.2).
Croatian: Preliminarni klinički podaci ukazuju da kombinacija lijeka CRIXIVAN od 400 mg i ritonavira od 100 mg, primijenjena peroralno dvaput na dan, može poslužiti kao alternativni režim doziranja (vidjeti dio 5.2).
English: • if you are taking any of the following medicines: - fusidic acid - an antibiotic used to treat infections - piroxicam - used for arthritis - alfuzosin - used for prostate problems - bepridil - used for chest pain (angina) - clozapine - used for some mental health problems - pethidine or propoxyphene - used for pain - estazolam or flurazepam - used to help you sleep - clorazepate or diazepam - used to make you calmer - encainide, flecanide, propafenone, or quinidine - used for uneven heartbeat problems.
Croatian: • ako uzimate neki od sljedećih lijekova: - fusidatnu kiselinu - antibiotik koji se koristi za liječenje infekcija - piroksikam - koristi se za artritis - alfuzosin - koristi se za tegobe s prostatom - bepridil - koristi se za bol u prsima (anginu) - klozapin - koristi se za neke tegobe s psihičkim zdravljem - petidin ili propoksifen - koriste se za ublažavanje boli - estazolam ili flurazepam - koriste se da lakše zaspete - klorazepat ili diazepam - koriste se za umirenje - enkainid, flekanid, propafenon ili kinidin - koriste se za tegobe s nepravilnim otkucajima srca.
English: Divalproex, lamotrigine, phenytoin
Croatian: Divalproeks, lamotrigin, fenitoin
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Croatian: U bolesnika zaraženih HIV-om s teškom imunodeficijencijom u vrijeme uvođenja kombiniranog antiretrovirusnog liječenja, može se razviti upalna reakcija na asimptomatske ili rezidualne oportunističke infekcije i uzrokovati ozbiljna klinička stanja ili pogoršanje simptoma.
English: Dose reduction of CRIXIVAN to 400-600 mg every 8 hours should be considered.
Croatian: Treba razmotriti smanjenje doze lijeka CRIXIVAN na 400-600 mg svakih 8 sati.
English: Not studied, combined administrations are expected to significantly increase concentrations of midazolam, particularly when midazolam is given orally.
Croatian: Nije ispitano, ali se očekuje da bi kombinirana primjena mogla dovesti do značajnih povišenja koncentracija midazolama, naročito kad se midazolam primjenjuje peroralno.