FrancophonIA/ELRC3.0 huggingface dataset:
English: The EC50 values for tenofovir were in the range of 0.04-8.5 microM.
Croatian: Vrijednosti EC50 za tenofovir kretale su se u rasponu od 0,04 do 8,5 µM.
English: The effects of tenofovir disoproxil associated changes in BMD and biochemical markers on long-term bone health and future fracture risk are unknown.
Croatian: Učinci promjena BMD-a i biokemijskih markera povezanih s tenofovirdizoproksilom na dugoročno zdravlje kostiju i budući rizik od prijeloma nisu poznati.
English: The marketing authorization holder (MAH) shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: A moderate amount of data on pregnant women (between 300-1,000 pregnancy outcomes) indicate no malformations or foetal/neonatal toxicity associated with tenofovir disoproxil.
Croatian: Umjerena količina podataka o trudnicama (između 300 i 1000 ishoda trudnoća) ne ukazuje na malformacije ni fetalnu/neonatalnu toksičnost povezanu s tenofovirdizoproksilom.
English: At baseline, the median age of subjects was 33 years (range 18 to 69 years), 86 % had CD4
Croatian: Medijan dobi ispitanika na početku ispitivanja iznosio je 33 godine (raspon: 18 - 69 godina), 86% imalo je broj CD4
English: You may need blood tests to check how your liver is working for 4 months after stopping treatment.
Croatian: Možda ćete trebati krvne pretrage kako biste provjerili rad jetre tijekom 4 mjeseca nakon završetka liječenja.
English: In a population pharmacokinetic analysis, which included subjects with CrCl between 17 and 317 mL/min, renal function did not have a clinically relevant effect on doravirine pharmacokinetics.
Croatian: U populacijskoj farmakokinetičkoj analizi, koja je uključivala ispitanike kojima je klirens kreatinina (CrCl) bio između 17 i 317 ml/min, funkcija bubrega nije klinički značajno utjecala na farmakokinetiku doravirina.
English: If Delstrigo is stopped your doctor may recommend that you resume hepatitis B treatment.
Croatian: Ako prestanete uzimati Delstrigo, liječnik će Vam možda preporučiti da nastavite primjenjivati terapiju za hepatitis B.
English: Co-administration should be avoided.
Croatian: Potrebno je izbjegavati istodobnu primjenu.
English: It is preferable to avoid the use of Delstrigo during pregnancy.
Croatian: Poželjno je izbjegavati primjenu lijeka Delstrigo tijekom trudnoće.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Croatian: Lamivudin nije bio teratogen u ispitivanjima na životinjama, ali bilo je pokazatelja porasta stope rane smrti zametaka u kunića pri relativno niskim razinama sistemske izloženosti, usporedivima s onima koje se postižu u ljudi.
English: Genotypic analysis showed that the resistance was due to a specific amino acid substitution in the HIV-1 RT at codon 184 changing the methionine to either isoleucine or valine (M184V/I).
Croatian: Genotipska analiza pokazala je da je rezistencija uzrokovana specifičnom aminokiselinskom supstitucijom u reverznoj transkriptazi HIV-1 na kodonu 184, kojom je metionin zamijenjen izoleucinom ili valinom (M184V/I).
English: *The 95 % CI for the treatment difference was calculated using stratum-adjusted Mantel-Haenszel method.
Croatian: *Interval pouzdanosti od 95% (95% CI) za razliku u liječenju izračunat je koristeći Mantel-Haenszel metodu prilagođenu stratumu.
English: A large amount of data on pregnant women (more than 3,000 outcomes from first trimester) taking the individual active component lamivudine in combination with other antiretrovirals indicates no malformative toxicity.
Croatian: Velika količina podataka o trudnicama (više od 3000 ishoda trudnoća nakon izloženosti u prvom tromjesečju) liječenima lamivudinom kao zasebnom djelatnom tvari u kombinaciji s drugim antiretroviroticima ne ukazuje na malformacijsku toksičnost.
English: This can happen when you start taking any HIV medicine, including Delstrigo.
Croatian: Može se javiti kada počnete uzimati bilo koji lijek za liječenje infekcije HIV-om, uključujući Delstrigo.
English: If you are not sure, talk to your doctor, pharmacist, or nurse before taking Delstrigo.
Croatian: Ako niste sigurni, razgovarajte s liječnikom, ljekarnikom ili medicinskom sestrom prije nego uzmete Delstrigo.
English: • if you are allergic to doravirine, lamivudine or tenofovir disoproxil or any of the other ingredients of this medicine listed in section 6.
Croatian: • ako ste alergični na doravirin, lamivudin ili tenofovirdizoproksil ili neki drugi sastojak ovog lijeka naveden u dijelu 6.
English: Because of the potential for HIV-1 transmission and the potential for serious adverse reactions in breast-feeding infants, mothers should be instructed not to breast-feed if they are receiving Delstrigo.
Croatian: Zbog mogućeg prijenosa HIV-1 i mogućnosti ozbiljnih nuspojava u dojenčadi, majke je potrebno uputiti da ne doje ako se liječe lijekom Delstrigo.
English: However, co-administration of doravirine and the sensitive CYP3A substrate midazolam resulted in a 18 % decrease in midazolam exposure, suggesting that doravirine may be a weak CYP3A inducer.
Croatian: Međutim, istodobna primjena doravirina i CYP3A osjetljivog supstrata midazolama smanjila je izloženost midazolamu za 18%, što ukazuje na to da bi doravirin mogao biti slab induktor CYP3A.
English: The adverse reactions with suspected (at least possible) relationship to treatment are listed below by body system organ class and frequency.
Croatian: Nuspojave kod kojih postoji sumnja na (barem moguću) povezanost s liječenjem navedene su u nastavku prema klasifikaciji organskih sustava i učestalosti.
English: Kinase Inhibitors dabrafenib
Croatian: Inhibitori kinaze dabrafenib
English: Delstrigo works by preventing HIV from making more viruses in your body.
Croatian: Delstrigo sprječava HIV da stvori nove kopije virusa u tijelu.
English: The efficacy of doravirine is based on the analyses of 96-week data from two randomised, multicentre, double-blind, active controlled Phase 3 trials, (DRIVE-FORWARD and DRIVE-AHEAD) in antiretroviral treatment-naïve, HIV-1 infected subjects (n = 1494).
Croatian: Djelotvornost doravirina temelji se na analizama 96-tjednih podataka iz dvaju randomiziranih, multicentričnih, dvostruko slijepih, aktivnim lijekom kontroliranih ispitivanja faze 3 (DRIVE-FORWARD i DRIVE-AHEAD), provedenih u ispitanika s HIV-1 infekcijom koji prethodno nisu bili liječeni antiretroviroticima (n=1494).
English: Administration of doravirine in animal toxicity studies was not associated with toxicity.
Croatian: Doravirin Primjena doravirina u ispitivanjima toksičnosti na životinjama nije bila povezana s toksičnošću.
English: • inflammation of the skin due to allergy, redness on the cheeks, nose, chin or forehead, bumps or pimples on the face, swelling of the face, lips, tongue or throat
Croatian: • upala kože zbog alergije, crvenilo obraza, nosa, brade ili čela, kvržice ili prištići na licu, oticanje lica, usana, jezika ili grla
English: Rare rectal tenesmus
Croatian: rijetko rektalni tenezmus
English: • lumacaftor
Croatian: • lumakaftor
English: Delstrigo is used to treat HIV (‘human immunodeficiency virus') infection.
Croatian: Delstrigo se koristi za liječenje infekcije virusom humane imunodeficijencije (engl. human immunodeficiency virus, HIV).
English: Delstrigo contains lactose monohydrate.
Croatian: Delstrigo sadrži laktozu hidrat.
English: Method of administration Delstrigo must be taken orally, once daily with or without food and swallowed whole (see section 5.2).
Croatian: Delstrigo se mora uzimati peroralno, jedanput na dan, s hranom ili bez nje, a tableta se mora progutati cijela (vidjeti dio 5.2).
English: Special care is advised in this age group due to age associated changes such as decreases in renal function (see section 4.4).
Croatian: U toj se dobnoj skupini preporučuje poseban oprez zbog promjena povezanih s dobi, kao što je smanjenje funkcije bubrega (vidjeti dio 4.4).
English: Documentation of pretreatment resistance genotyping was not required for patients who switched from a NNRTI-based regimen.
Croatian: Dokumentacija o genotipizaciji rezistencije prije liječenja nije bila potrebna za bolesnike koji su prešli s režima temeljenog na NNRTI-jima.
English: The administration of a single Delstrigo tablet with a high-fat meal to healthy subjects resulted in a 26 % increase in doravirine C24, while AUC and Cmax were not significantly affected.
Croatian: Primjena jedne tablete lijeka Delstrigo uz obrok s visokim udjelom masti u zdravih ispitanika povećala je C24 doravirina za 26%, dok na AUC i Cmax nije značajno utjecala.
English: At baseline, the median age of subjects was 43 years, 16 % were female, and 24 % were nonwhite.
Croatian: Na početku ispitivanja medijan dobi ispitanika bio je 43 godine, 16% bile su žene, a 24% ispitanika nisu bili bijelci.
English: The pharmacokinetics of lamivudine and tenofovir have not been studied in subjects older than 65 years.
Croatian: Farmakokinetika lamivudina i tenofovira nije se ocjenjivala u ispitanika starijih od 65 godina.
English: Intracellularly, lamivudine is phosphorylated to its active 5´- triphosphate metabolite, lamivudine triphosphate (3TC-TP).
Croatian: Unutar stanice lamivudin se fosforilira do svog aktivnog 5´-trifosfatnog metabolita, lamivudintrifosfata (3TC-TP).
English: However, no dose adjustment is needed when doravirine is co-administered with CYP3A inhibitors.
Croatian: Međutim, nije potrebno prilagođavati dozu kada se doravirin primjenjuje istodobno s inhibitorima CYP3A.
English: • hair loss, rash
Croatian: • gubitak kose, osip
English: As a precautionary measure, it is preferable to avoid the use of Delstrigo during pregnancy.
Croatian: Kao mjera opreza, poželjno je izbjegavati primjenu lijeka Delstrigo u trudnoći.
English: Cystic Fibrosis Treatment lumacaftor
Croatian: Terapija za cističnu fibrozu lumakaftor
English: The use of Delstrigo in people aged less than 18 years has not yet been studied.
Croatian: Primjena lijeka Delstrigo u osoba mlađih od 18 godina još nije ispitana.
English: Warnings and precautions Talk to your doctor, pharmacist, or nurse before taking Delstrigo.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete Delstrigo.
English: Excretion of unchanged medicinal product via urinary excretion is minor.
Croatian: Izlučivanje nepromijenjenog lijeka kroz mokraću je neznatno.
English: Doravirine There is no information on potential acute symptoms and signs of overdose with doravirine.
Croatian: Nema informacija o mogućim akutnim simptomima i znakovima predoziranja doravirinom.
English: This will help by:
Croatian: Na taj način:
English: If you stop taking Delstrigo
Croatian: Ako prestanete uzimati Delstrigo
English: Tenofovir disoproxil is efficiently removed by haemodialysis with an extraction coefficient of approximately 54 %.
Croatian: Tenofovirdizoproksil se učinkovito uklanja hemodijalizom, uz koeficijent ekstrakcije od približno 54%.
English: • muscle weakness, weakening of the bones (with bone pain and sometimes resulting in fractures)
Croatian: • mišićna slabost, slabljenje kostiju (koje je praćeno bolovima u kostima i ponekad dovodi do prijeloma)
English: The recommended dose of Delstrigo is one 100/300/245 mg tablet taken orally once daily with or without food.
Croatian: Preporučena doza lijeka Delstrigo je jedna tableta od 100/300/245 mg koja se uzima peroralno jedanput na dan, s hranom ili bez nje.
English: Monitor blood concentrations of tacrolimus and sirolimus as the dose of these agents may need to be adjusted.
Croatian: Potrebno je pratiti koncentracije takrolimusa i sirolimusa u krvi jer će možda biti potrebno prilagoditi doze tih lijekova.
English: Doravirine has an estimated absolute bioavailability of approximately 64 % for the 100 mg tablet.
Croatian: Procijenjena apsolutna bioraspoloživost doravirina iznosi približno 64% za tabletu od 100 mg.
English: If you have both HIV and hepatitis B virus infections, your hepatitis B may get worse if you stop taking Delstrigo.
Croatian: Ako ste zaraženi i HIV-om i virusom hepatitisa B, može doći do pogoršanja hepatitisa B ako prestanete uzimati Delstrigo.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Delstrigo in one or more subsets of the paediatric population in treatment of human immunodeficiency virus-1 (HIV-1) infection, as per Paediatric Investigation Plans (PIP) decision in the granted indication.
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Delstrigo u jednoj ili više podskupina pedijatrijske populacije u liječenju infekcije virusom humane imunodeficijencije 1 (HIV-1), sukladno odluci o Planovima istraživanja u pedijatrijskoj populaciji [engl.
English: In most singledose trials in HIV-1 infected subjects, or healthy subjects with serum sampling for 24 hours after dosing, the observed mean elimination half-life (t½) ranged from 5 to 7 hours.
Croatian: U većini ispitivanja jednokratne doze provedenih u ispitanika s HIV-1 infekcijom ili zdravih ispitanika kojima su se uzorci seruma uzimali tijekom 24 sata nakon primjene, opažena srednja vrijednost poluvremena eliminacije (t½) kretala se između 5 i 7 sati.
English: • difficulty breathing, enlarged tonsils
Croatian: • otežano disanje, povećani krajnici
English: Doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor of HIV-1 and inhibits HIV-1 replication by non-competitive inhibition of HIV-1 reverse transcriptase (RT).
Croatian: Doravirin je piridinonski nenukleozidni inhibitor reverzne transkriptaze HIV-1 koji inhibira replikaciju HIV-1 nekompetitivnom inhibicijom reverzne transkriptaze (RT) HIV-1.
English: Assessment of BMD should be considered for HIV-1 infected adult patients who have a history of pathologic bone fracture or other risk factors for osteoporosis or bone loss.
Croatian: Ocjenu BMD-a treba razmotriti u odraslih bolesnika s HIV-1 infekcijom koji u anamnezi imaju patološke prijelome kostiju ili druge faktore rizika za osteoporozu ili gubitak kosti.
English: EC50 values were in the range of 0.003 to 15 microM (1 microM = 0.23 micrograms per mL).
Croatian: Vrijednosti EC50 kretale su se u rasponu od 0,003 do 15 µM (1 µM=0,23 mikrograma/ml).
English: Based on the results of in vitro experiments and the known elimination pathway of tenofovir, the potential for CYP-mediated interactions involving tenofovir with other medicinal products is low.
Croatian: Na temelju rezultata pokusa in vitro i poznatog puta eliminacije tenofovira, potencijal za interakcije posredovane CYP enzimima između tenofovira i drugih lijekova je nizak.
English: Approximately 71 % of an intravenous dose of lamivudine is recovered as unchanged medicinal product in the urine.
Croatian: Približno 71% intravenski primijenjene doze lamivudina pronalazi se u obliku nepromijenjena lijeka u mokraći.
English: • lactic acidosis (excess lactic acid in the blood)
Croatian: • laktacidozu (višak mliječne kiseline u krvi)
English: It is recommended that estimated CrCl be assessed in all patients prior to initiating therapy and as clinically appropriate during therapy with Delstrigo.
Croatian: Preporučuje se utvrditi procijenjeni CrCl u svih bolesnika prije uvođenja terapije te prema kliničkoj potrebi tijekom liječenja lijekom Delstrigo.
English: • decreased levels of magnesium
Croatian: • snižene razine magnezija
English: Includes subjects who discontinued study drug or study before Week 48 for ISG or before Week 24 for DSG for lack or loss of efficacy and subjects with HIV-1 RNA ≥ 40 copies/mL in the Week 48 window for ISG and in the Week 24 window for DSG.
Croatian: Uključuje ispitanike koji su prekinuli ispitivanje prije 48. tjedna za ISG ili prije 24. tjedna za DSG zbog nedostatne ili gubitka djelotvornosti, te ispitanike koji su imali HIV-1 RNK ≥ 40 kopija/ml u 48. tjednu za ISG okvir i u 24. tjednu za DSG okvir.
English: Doravirine is primarily eliminated via oxidative metabolism mediated by CYP3A4.
Croatian: Doravirin se primarno eliminira oksidacijskim metabolizmom u kojem posreduje CYP3A4.
English: In some subjects treated with zidovudine plus didanosine, isolates resistant to multiple RT inhibitors, including lamivudine, have emerged.
Croatian: U nekih ispitanika liječenih zidovudinom plus didanozinom pojavili su se izolati rezistentni na više inhibitora reverzne transkriptaze, uključujući lamivudin.
English: Store in the original bottle and keep the bottle tightly closed to protect from moisture.
Croatian: Čuvati u originalnoj boci, a bocu držati čvrsto zatvorenom radi zaštite od vlage.
English: Bottle label
Croatian: Naljepnica boce
English: • enlarged liver or fatty liver, yellow skin or eyes, pain in the belly (abdomen) caused by inflammation of the liver
Croatian: • povećana jetra ili masna jetra, žuta koža ili oči, bol u trbuhu (abdomenu) uzrokovana upalom jetre
English: Delstrigo contains doravirine, lamivudine, and tenofovir disoproxil, therefore any interactions identified for these individually are relevant to Delstrigo and are presented in Table 1.
Croatian: Budući da Delstrigo sadrži doravirin, lamivudin i tenofovirdizoproksil, sve interakcije utvrđene za svaku od tih djelatnih tvari pojedinačno relevantne su i za Delstrigo te se navode u Tablici 1.
English: See list under “Do not take Delstrigo” section.
Croatian: Pogledajte popis u odlomku „Nemojte uzimati Delstrigo“.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of doravirine in milk (see section 5.3).
Croatian: Dostupni farmakodinamički/toksikološki podaci u životinja pokazuju da se doravirin izlučuje u mlijeko (vidjeti dio 5.3).
English: Week 48 outcome (< 40 copies/mL) by baseline factors
Croatian: Ishod u 48. tjednu (<40 kopija/ml) prema početnim faktorima
English: • if you are taking any of the following medicines: - carbamazepine, oxcarbazepine, phenobarbital, phenytoin (medicines for seizure) - rifampicin, rifapentine (medicines for tuberculosis) - St. John's wort (Hypericum perforatum, a herbal remedy used for depression and anxiety) or products that contain it - mitotane (a medicine to treat cancer) - enzalutamide (a medicine to treat prostate cancer) - lumacaftor (a medicine to treat cystic fibrosis)
Croatian: • ako uzimate bilo koji od sljedećih lijekova: karbamazepin, okskarbazepin, fenobarbital, fenitoin (lijekovi za napadaje) rifampicin, rifapentin (lijekovi za tuberkulozu) gospinu travu (Hypericum perforatum, biljni lijek koji se koristi za liječenje depresije i tjeskobe) ili lijekove koji je sadrže mitotan (lijek za liječenje raka) enzalutamid (lijek za liječenje raka prostate) lumakaftor (lijek za liječenje cistične fibroze).
English: Bone toxicity was diagnosed as osteomalacia (monkeys) and reduced bone mineral density (BMD) (rats and dogs).
Croatian: Toksičnost za kosti dijagnosticirana je kao osteomalacija (u majmuna) i smanjena mineralna gustoća kosti (u štakora i pasa).
English: If your doctor decides you should take these medicines with Delstrigo, your doctor will prescribe a 100 mg tablet of doravirine to be taken daily, approximately 12 hours after your dose of Delstrigo.
Croatian: Ako Vaš liječnik odluči da trebate uzimati te lijekove zajedno s lijekom Delstrigo, propisat će Vam i jednu tabletu doravirina od 100 mg na dan, koju ćete uzimati približno 12 sati nakon doze lijeka Delstrigo.
English: • increased levels of lipase
Croatian: • povišene vrijednosti lipaze
English: *NRTI in DOR arm: FTC/TDF (333) or ABC/3TC (50); NRTI in DRV+r arm: FTC/TDF (335) or ABC/3TC (48) **Subjects received FTC/TDF
Croatian: *NRTI u skupini koja je primala doravirin (DOR): FTC/TDF (333) ili ABC/3TC (50); NRTI u skupini koja je primala darunavir pojačan ritonavirom (DRV+r): FTC/TDF (335) ili ABC/3TC (48) **Ispitanici su primili FTC/TDF
English: Antiandrogens enzalutamide
Croatian: Antiandrogeni enzalutamid
English: Following oral dosing, peak plasma concentrations are achieved 2 hours after dosing.
Croatian: Vršne koncentracije u plazmi nakon peroralne primjene postižu se 2 sata nakon primjene.
English: fluconazole itraconazole posaconazole voriconazole
Croatian: flukonazol itrakonazol posakonazol vorikonazol
English: You may require blood tests for several months after stopping treatment.
Croatian: Možda ćete morati odlaziti na krvne pretrage tijekom nekoliko mjeseci nakon završetka liječenja.
English: • dabrafenib (a medicine to treat skin cancer)
Croatian: • dabrafenib (lijek za liječenje raka kože)
English: Of the 7 subjects who developed high level doravirine resistance in the pivotal studies, 6 had phenotypic resistance to EFV and nevirapine, 3 to rilpivirine, and 2 had partial resistance to etravirine based on the Monogram Phenosense assay.
Croatian: Od 7 ispitanika u kojih se razvila izražena rezistencija na doravirin u pivotalnim ispitivanjima, 6 ih je pokazivalo fenotipsku rezistenciju na efavirenz i nevirapin, 3 na rilpivirin, dok su 2 ispitanika pokazivala djelomičnu rezistenciju na etravirin, što je utvrđeno testom Monogram Phenosense.
English: The bone toxicity in young adult rats and dogs occurred at exposures ≥ 5-fold the exposure in paediatric or adult patients; bone toxicity occurred in juvenile infected monkeys at very high exposures following subcutaneous dosing (≥ 40-fold the exposure in patients).
Croatian: U mladih odraslih štakora i pasa toksičnost za kosti nastupila je pri izloženosti ≥ 5 puta većoj od izloženosti u pedijatrijskih ili odraslih bolesnika; toksičnost za kosti pojavila se u mladih zaraženih majmuna pri vrlo visokim razinama izloženosti nakon supkutane primjene (izloženost ≥ 40 puta veća od one koja se postiže u bolesnika).
English: Doravirine has not been evaluated in patients with previous virologic failure to any other antiretroviral therapy.
Croatian: Doravirin se nije ocjenjivao u bolesnika s izostankom virološkog odgovora tijekom prethodnog liječenja bilo kojom drugom antiretrovirusnom terapijom.
English: If appropriate, initiation of anti-hepatitis B therapy may be warranted, especially in patients with advanced liver disease or cirrhosis, since post-treatment exacerbation of hepatitis may lead to hepatic decompensation and liver failure.
Croatian: Ako to bude prikladno, možda će trebati uvesti terapiju za hepatitis B, osobito u bolesnika s uznapredovalom bolesti jetre ili cirozom, jer egzacerbacija hepatitisa nakon liječenja može dovesti do dekompenzacije jetre i zatajenja jetre.
English: Table 3: Resistance development up to week 96 in protocol defined virologic failure population + early discontinuation population
Croatian: Tablica 3: Razvoj rezistencije do 96. tjedna u populaciji s izostankom virološkog odgovora definiranog planom ispitivanja i populaciji koja se prijevremeno povukla iz ispitivanja
English: • pain in the chest, feeling cold, pain, thirst
Croatian: • bol u prsnom košu, osjećaj hladnoće, bol, žeđ
English: In other studies (prospective and cross-sectional), the most pronounced decreases in BMD were seen in patients treated with tenofovir disoproxil as part of a regimen containing a boosted protease inhibitor.
Croatian: U drugim ispitivanjima (prospektivnima i presječnima) najizraženija smanjenja BMD-a opažena su u bolesnika liječenih tenofovirdizoproksilom kao dijelom režima liječenja koji je sadržavao pojačan inhibitor proteaze.
English: It is unknown whether doravirine is excreted in human milk.
Croatian: Nije poznato izlučuje li se doravirin u majčino mlijeko.
English: • The bottle contains desiccant protecting the tablets from moisture.
Croatian: • Boca sadrži sredstvo za sušenje, koje tablete štiti od vlage.
English: Antineoplastics mitotane
Croatian: Antineoplastici mitotan
English: In clinical trials
Croatian: U kliničkim ispitivanjima