FrancophonIA/ELRC3.0 huggingface dataset:
English: The result is a reduction in intraocular pressure (IOP) which is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.
Danish: Resultatet heraf er et nedsat intraokulært tryk (IOP), som er en stor risikofaktor in patogenesen for beskadigelse af synsnerven og glaukomatøs synsfeltstab.
English: The cytochrome P-450 isozymes responsible for metabolism of brinzolamide include CYP3A4 (main), CYP2A6, CYP2C8 and CYP2C9.
Danish: De cytokrom p-450 isozymer, der er ansvarlige for metaboliseringen af brinzolamid, indbefatter CYP3A4 (hovedsagelig), CYP2A6, CYP2C8 og CYP2C9.
English: AZOPT has not been studied in patients wearing contact lenses.
Danish: AZOPT er ikke afprøvet hos patienter med kontaktlinser.
English: Nasolacrimal occlusion or gently closing the eyelid after instillation may help reduce the incidence of this effect (see also section 4.2).
Danish: Nasolacrimal okklusion eller forsigtig lukning af øjnene efter instillation kan mindske incidensen af denne bivirkning (se også pkt.
English: If you forget to use AZOPT
Danish: Hvis du har glemt at bruge AZOPT
English: Subjects with moderate renal impairment (creatinine clearance of 30-60 ml/minute) were administered 1 mg of brinzolamide twice daily orally for up to 54 weeks.
Danish: Individer med moderat nedsat nyre funktion (Creatinin clearance på 30-60 ml/minut) modtog 1-mg brinzolamid 2 gange dagligt oralt i op til 54 uger.
English: The safety and efficacy of AZOPT in infants, children and adolescents aged 0 to 17 years have not been established.
Danish: AZOPTs sikkerhed og virkning hos spædbørn, børn og unge i alderen 0 til 17 år er ikke klarlagt.
English: Talk to your doctor or pharmacist before using AZOPT: - if you have kidney or liver problems.
Danish: Kontakt lægen eller apotekspersonalet, før du bruger AZOPT - hvis du har nyre- eller leverproblemer.
English: • open-angle glaucoma as monotherapy in adult patients unresponsive to beta-blockers or in adult patients in whom betablockers are contraindicated, or as adjunctive therapy to beta-blockers or prostaglandin analogues (see also section 5.1).
Danish: • åbenvinklet glaukom som monoterapi til voksne patienter, der ikke har haft effekt af beta-blokkere, eller til voksne, hvor beta-blokkere er kontraindiceret, eller som supplerende terapi til beta-blokkere eller prostaglandinanaloger (se også pkt.
English: AZOPT is indicated to decrease elevated intraocular pressure in:
Danish: AZOPT er indiceret til at nedsætte et forhøjet intraokulært tryk hos patienter med:
English: Animal studies have shown the excretion of minimal levels of brinzolamide in breast milk following oral administration.
Danish: Dyrestudier har vist, at brinzolamid udskilles i mælk i minimale koncentrationer efter oral administration.
English: In small short-term clinical trials, approximately 12.5% of paediatric patients were observed to experience adverse reactions, the majority of which were local, non-serious ocular reactions such as conjunctival hyperaemia, eye irritation, eye discharge, and lacrimation increased (see also section 5.1).
Danish: I små kortvarige kliniske forsøg blev der observeret bivirkninger hos ca. 12,5 % af de pædiatriske patienter, hvoraf størstedelen var lokale, ikke-alvorlige reaktioner i øjet såsom konjunktival hyperæmi, øjenirritation, udflåd fra øjet og øget tåreproduktion (se også pkt.
English: No unexpected adverse reactions have been observed with AZOPT when used as adjunctive therapy to travoprost.
Danish: Der er ikke observeret nogen uventede bivirkninger med AZOPT, når det anvendes som supplerende terapi til travoprost.
English: In a topical ocular study, at steady-state, brinzolamide RBC concentrations were similar to those found in the oral study, but levels of N-desethylbrinzolamide were lower.
Danish: I et topikalt okulært studie var steady-state for brinzolamid RBC koncentrationerne identisk med koncentrationerne fundet i det orale studie, men niveauet for N-desethyl-brinzolamid var lavere.
English: It is expected that inhibitors of CYP3A4 such as ketoconazole, itraconazole, clotrimazole, ritonavir and troleandomycin will inhibit the metabolism of brinzolamide by CYP3A4.
Danish: Man kan forvente, at CYP3A4 inhibitorer som ketokonazol, itrakonazol, clotrimazol, ritonavir og troleandomycin kan hæmme metaboliseringen af brinzolamid via CYP3A4.
English: AZOPT has not been studied in patients with severe renal impairment (creatinine clearance < 30 ml/min) or in patients with hyperchloraemic acidosis.
Danish: AZOPT øjendråber er ikke undersøgt hos patienter med svært nedsat nyrefunktion (kreatininclearance <30 ml/min) eller hos patienter med hyperkloræmisk acidose.
English: Among patients who were on topical IOP-lowering medicinal product(s) (22 patients), mean IOP increased slightly from baseline in the AZOPT group.
Danish: Blandt de patienter, som i forvejen fik topikal IOP-sænkende medicin (22 patienter), steg den gennemsnitlige IOP en smule i forhold til baseline i AZOPT-gruppen.
English: Pharmacotherapeutic group: Antiglaucoma preparations and miotics, carbonic anhydrase inhibitors, ATC code: S01EC04
Danish: Farmakoterapeutisk klassifikation: Anti-glaukom præparater og miotika, karboanhydrase-hæmmere, ATC-kode: S01EC04
English: Do not use AZOPT unless clearly indicated by your doctor.
Danish: Brug ikke AZOPT, medmindre din læge har anbefalet det.
English: Uncommon: red blood cell count decreased, blood chloride increased
Danish: Ikke almindelig: nedsat antal røde blodlegemer, øget koncentration af chlorid i blodet
English: There is limited experience with AZOPT in the treatment of patients with pseudoexfoliative glaucoma or pigmentary glaucoma.
Danish: Der er begrænset erfaring med AZOPT til behandling af patienter med pseudoeksfoliativ glaukom eller pigmentglaukom.
English: • Do not squeeze the bottle: it is designed so that a gentle press on the bottom is all that it needs
Danish: • Tryk ikke på siden af flasken, da den er designet på en sådan måde, at et let tryk i bunden af flasken er alt, der skal til (figur 2).
English: In an oral pharmacokinetic study, healthy volunteers received 1 mg capsules of brinzolamide twice daily for up to 32 weeks and RBC CA activity was measured to assess the degree of systemic CA inhibition.
Danish: I et oralt farmakokinetisk studie, fik raske frivillige 1-mg kapsler med brinzolamid 2 gange dagligt i op til 32 uger, og de RBCs kulsyre-anhydrase (CA) aktivitet blev målt til at opnå samme niveau som systemisk CA-hæmning.
English: In clinical studies involving 2732 patients treated with AZOPT as monotherapy or adjunctive therapy to timolol maleate 5 mg/ml, the most frequently reported treatment-related adverse reactions were: dysgeusia (6.0%) (bitter or unusual taste, see description below) and temporary blurred vision (5.4%) upon instillation, lasting from a few seconds to a few minutes (see also section 4.7).
Danish: I kliniske studier med mere end 2.732 patienter behandlet med AZOPT som monoterapi eller som tillægsterapi til timolol maleat 5 mg/ml var de hyppigste behandlingsrelaterede bivirkninger dysgeusi (6,0%) (bitter eller unormal smag, se beskrivelsen nedenunder) og forbigående sløret syn (5,4%), der varede fra få sekunder til få minutter (se også pkt.
English: Dose-related decreases in foetal weights were observed in pups of dams receiving brinzolamide orally ranging from a slight decrease (about 5-6%) at 2 mg/kg/day to nearly 14% at 18 mg/kg/day.
Danish: Dosis-relateret nedsættelse i fostrenes kropsvægt blev observeret hos hvalpe af mødre, der modtog oral brinzolamid, og var fra et svagt fald (ca. 5-6%) ved 2 mg/kg/dag til næsten 14% ved 18 mg/kg/dag.
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from AZOPT therapy taking in to account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Danish: Det skal besluttes, om amning skal ophøre eller behandling med AZOPT seponeres, idet der tages højde for fordelene ved amning for barnet i forhold til de terapeutiske fordele for moderen.
English: No long term data are available on the use of AZOPT as adjunctive therapy to travoprost(see also section 5.1).
Danish: Der er ingen langtidsdata om anvendelsen af AZOPT som supplerende behandling til travaprost (se også pkt.
English: If you are using other eye drops, leave at least 5 minutes between putting in AZOPT and the other drops.
Danish: Hvis du bruger andre øjenpræparater, så vent mindst 5 minutter mellem AZOPT og de andre øjenpræparater.
English: AZOPT may impair the ability to perform tasks requiring mental alertness and/or physical coordination.
Danish: AZOPT kan forringe evnen til at udføre opgaver, der kræver mental årvågenhed og/eller fysisk koordination.
English: Temporary blurred vision or other visual disturbances may affect the ability to drive or use machines (see also section 4.8).
Danish: Forbigående sløret syn og andre synsforstyrrelser kan påvirke evnen til at føre motorkøretøjer og betjene maskiner (se også pkt.
English: Brinzolamide saturation of RBC CA-II was achieved within 4 weeks (RBC concentrations of approximately 20 µM).
Danish: Mætningen med brinzolamid af RBCs CA-II blev opnået indenfor 4 uger (RBC koncentrationen på ca. 20 M).
English: What you need to know before you use AZOPT
Danish: Det skal du vide, før du begynder at bruge AZOPT
English: Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humour secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
Danish: Ved at hæmme karboanhydrase i øjets ciliære processer nedsættes kammervand sekretionen, formodentlig ved at sinke dannelsen af bikarbonationer medførende reduktion i natrium og væske transport.
English: Uncommon: foreign body in eye
Danish: Ikke almindelig: følelse af fremmedlegeme i øjet
English: A clinical trial was conducted with AZOPT in 32 paediatric patients less than 6 years of age, diagnosed with glaucoma or ocular hypertension.
Danish: Der blev gennemført et klinisk forsøg med AZOPT hos 32 børn på under 6 år med glaukom eller okulær hypertension.
English: AZOPT contains brinzolamide which belongs to a group of medicines called carbonic anhydrase inhibitors.
Danish: AZOPT indeholder brinzolamid, der tilhører en gruppe af lægemidler, der kaldes karboanhydrasehæmmere.
English: Opened (1): Opened (2): Opened (3):
Danish: Åbnet (1): Åbnet (2): Åbnet (3):
English: Nasolacrimal occlusion or gently closing the eyelid after instillation is recommended.
Danish: Nasolakrimal okklusion eller rolig lukning af øjet efter drypning anbefales.
English: Instruct the patient to shake the bottle well before use.
Danish: Patienten skal instrueres i at ryste flasken grundigt inden brug.
English: If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation.
Danish: Såfremt der opstår tegn på eller tilfælde af alvorlige bivirkninger eller overfølsomhedsreaktioner, afbrydes behandlingen.
English: AZOPT is not recommended for use in infants, children and adolescents.
Danish: AZOPT anbefales ikke til spædbørn, børn og unge.
English: - if you are allergic to brinzolamide or any of the other ingredients of this medicine (listed in section 6).
Danish: - hvis du er allergisk over for brinzolamid eller et af de øvrige indholdsstoffer i dette lægemiddel
English: The concomitant administration of AZOPT and oral carbonic anhydrase inhibitors has not been studied and is not recommended (see also section 4.5).
Danish: Den samtidige behandling med AZOPT øjendråber og orale karboanhydrasehæmmere er ikke undersøgt og kan derfor ikke anbefales (se også pkt.
English: There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and AZOPT.
Danish: Der er en mulig additiv effekt af den kendte systemiske effekt af karboanhydrase-hæmmere hos patienter, som både behandles med en oral karboanhydrase-hæmmer og AZOPT øjendråber.
English: When used as monotherapy or adjunctive therapy, the dose is one drop of AZOPT in the conjunctival sac of the affected eye(s) twice daily.
Danish: Når AZOPT anvendes som monoterapi eller som supplerende terapi, er dosis 1 dråbe 2 gange daglig appliceret i den konjunktivale sæk i det pågældende øje/de pågældende øjne.
English: Not Known: liver function test abnormal
Danish: Ikke kendt: abnorm leverfunktionstest
English: Association between AZOPT and miotics or adrenergic agonists has not been evaluated during adjunctive glaucoma therapy.
Danish: Sammenhæng mellem AZOPT øjendråber og miotika eller adrenerge antagonister er ikke evalueret under samtidig glaukom-terapi.
English: Uncommon: cardio-respiratory distress, bradycardia, palpitations
Danish: Ikke almindelig: hjerte- og respirationsbesvær, bradykardi, palpitationer
English: Use with caution in patients with risk of renal impairment because the possible risk of metabolic acidosis (see section 4.2).
Danish: Bør anvendes med forsigtighed til patienter med risiko for nedsat nyrefunktion pga. risiko for metabolisk acidose (se pkt.
English: Similar studies in rats resulted in slightly reduced ossification of skull and sternebrae of foetuses of dams receiving brinzolamide at doses of 18 mg/kg/day (375 times the recommended human ophthalmic dose), but not 6 mg/kg/day.
Danish: Tilsvarende studier med rotter resulterede i en svagt nedsat ossifikation af kraniet og sternebrae på fostre af mødre, der fik brinzolamid i doser på 18 mg/dag (375 gange den anbefalede human dosering i øjet), men ikke ved 6 mg/kg/dag.
English: If blurred vision occurs at instillation, the patient must wait until the vision clears before driving or using machines.
Danish: Hvis der opstår sløret syn efter drypning, skal patienten vente med at føre motorkøretøj og betjene maskiner, indtil synet er klart igen.
English: Rare: angina pectoris, heart rate irregular Not Known: arrhythmia, tachycardia, hypertension, blood pressure increased, blood pressure decreased, heart rate increased
Danish: Sjælden: angina pectoris, uregelmæssig hjerterytme Ikke kendt: arytmi, takykardi, hypertension, forhøjet blodtryk, nedsat blodtryk, øget hjerterytme
English: N-Desethylbrinzolamide accumulated in RBCs to steady state within 2028 weeks reaching concentrations ranging from 6-30 µM.
Danish: N-desethyl-brinzolamid akkumuleredes i RBC til steady-state i løbet af 20-28 uger med koncentrationer fra 6-30 M.
English: Rare side effects (may affect up to 1 in 1,000 people)
Danish: Sjældne bivirkninger (kan forkomme hos op til 1 ud af 1.000 personer)
English: Brinzolamide RBC concentration ranged from about 20 to 40 µM by week 4 of treatment.
Danish: Brinzolamid RBC-koncentrationen var fra omkring 20 til 40 M efter 4 ugers behandling.
English: Contains benzalkonium chloride, mannitol (E421), carbomer 974P, tyloxapol, edetate disodium, sodium chloride, hydrochloric acid/sodium hydroxide (to adjust pH) and purified water.
Danish: Indeholder benzalkoniumchlorid, mannitol (E421), carbomer 974P, tyloxapol, dinatriumedetat, natriumchlorid, saltsyre/natriumhydroxid (til at justere pH) og renset vand.
English: What AZOPT looks like and contents of the pack AZOPT is a milky liquid (a suspension) supplied in a pack containing a 5 ml or a 10 ml plastic (droptainer) bottle with a screw cap, or in a pack containing three 5 ml plastic (droptainer) bottles with screw caps.
Danish: AZOPT er en mælkehvid væske (en suspension), der fås i 5 ml eller 10 ml plastikflasker (droptainer) med skruelåg, eller i tre 5 ml plastikflasker (droptainer) med skruelåg.
English: Rare: tinnitus Not Known: vertigo
Danish: Sjælden: tinnitus Ikke kendt: svimmelhed
English: Uncommon: apathy, depression, depressed mood, libido decreased, nightmare, nervousness Rare: insomnia
Danish: Ikke almindelig: apati, depression, depressiv sindsstemning, nedsat libido, mareridt, nervøsitet Sjælden: søvnløshed
English: AZOPT 10 mg/ml eye drops, suspension
Danish: AZOPT 10 mg/ml øjendråber, suspension
English: • Hold the bottle, pointing down, between your thumb and middle finger
Danish: • Hold flasken med bunden i vejret mellem tommel- og langfinger.
English: - The other ingredients are benzalkonium chloride, carbomer 974P, edetate disodium, mannitol (E421), purified water, sodium chloride, tyloxapol.
Danish: - Øvrige indholdsstoffer: Benzalkoniumchlorid, carbomer 974P, dinatriumedetat, mannitol (E421), renset vand, natriumchlorid og tyloxapol.
English: Mannitol (E421)
Danish: Benzalkoniumchlorid Mannitol (E421)
English: S.A. Alcon-Couvreur N.V., Rijksweg 14,
Danish: SA Alcon-Courveur NV Rijksweg 14
English: Pull down your eyelid with a clean finger, until there is a ‘pocket' between the eyelid and your eye.
Danish: Træk forsigtig ned i dit nederste øjenlåg, indtil der dannes en “lomme”
English: Rare: memory impairment, somnolence Not Known: tremor, hypoaesthesia, ageusia
Danish: Sjælden: hukommelsessvækkelse, døsighed Ikke kendt: tremor, hypæstesi, ageusi
English: Careful monitoring of patients with compromised corneas such as patients with diabetes mellitus or corneal dystrophies is recommended.
Danish: Omhyggelig monitorering anbefales hos patienter med kompromitteret cornea eller corneadystrofi, som f.eks. diabetikere.
English: The same type of adverse reactions that are attributable to oral carbonic anhydrase inhibitors may occur with topical administration.
Danish: De samme typer uønskede virkninger, der kan skyldes orale karboanhydrase-hæmmere, kan opstå efter topikal administration.
English: Benzalkonium chloride, which is commonly used as a preservative in ophthalmic products, has been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy.
Danish: Benzalkoniumchlorid, som ofte anvendes som konserveringsmiddel i øjen-præparater, kan ifølge rapporter forårsage punktformet keratopati og/eller toksisk ulcerøs keratopati.
English: AZOPT is not recommended during pregnancy and in women of childbearing potential not using contraception.
Danish: AZOPT bør ikke anvendes under graviditet eller til kvinder i den fertile alder, der ikke anvender sikker kontraception.
English: Among patients who were naive to IOP therapy (10 patients), the efficacy of AZOPT was similar to that seen previously in adults, with mean IOP reductions from baseline ranging up to 5 mmHg.
Danish: Blandt patienterne, som i forvejen ikke fik IOP-sænkende medicin (10 patienter), var virkningen af AZOPT den samme, som er set hos voksne med gennemsnitlige IOP-reduktioner i forhold til baseline på op til 5 mmHg.
English: The potential for interactions must be considered in patients receiving AZOPT.
Danish: Potentialet for sådanne medikamentelle interaktioner skal overvejes ved brug af AZOPT.
English: Uncommon: renal pain Not Known: pollakiuria
Danish: Ikke almindelig: nyresmerter Ikke kendt: pollakisuri
English: Brinzolamide and N-desethylbrinzolamide are the predominant components in the urine along with trace levels (<1%) of the N-desmethoxypropyl and O-desmethyl metabolites.
Danish: Brinzolamid og N-Desethyl-brinzolamid er den prædominante komponent fundet i urinen sammen med mindre koncentrationer af N-desmethoxypropyl og O-desmethyl metabolitter.
English: In humans, the metabolite N-desethylbrinzolamide is formed, which also binds to CA and accumulates in RBCs.
Danish: I den menneskelige organisme dannes metabolitten N-desethyl-brinzolamid som ligeledes bindes til kulsyre-anhydrasen (CA) og akkumuleres i deRBC.
English: When substituting another ophthalmic antiglaucoma agent with AZOPT, discontinue the other agent and start the following day with AZOPT.
Danish: Hvis AZOPT erstatter andre øjendråber mod glaukom, seponeres disse, og behandling med AZOPT påbegyndes den efterfølgende dag
English: AZOPT eye drops are used to treat high pressure in the eye.
Danish: AZOPT anvendes til at sænke forhøjet tryk i øjet.
English: Since brinzolamide and its main metabolite are excreted predominantly by the kidney, AZOPT is therefore contra-indicated in such patients (see also section 4.3).
Danish: Brinzolamid og hovedmetabolitten udskilles overvejende renalt, hvorfor AZOPT øjendråber er kontraindiceret hos denne patientgruppe (se også pkt.
English: Specifically, patients wearing contact lenses have not been studied and careful monitoring of these patients when using brinzolamide is recommended, since carbonic anhydrase inhibitors may affect corneal hydration and wearing contact lenses might increase the risk for the cornea.
Danish: Patienter med kontaktlinser er ikke blevet undersøgt, og forsigtighed med AZOPT anbefales, da karboanhydrase-hæmmere kan påvirke væsketilførslen til cornea.
English: AZOPT has not been studied in patients with narrowangle glaucoma and its use is not recommended in these patients.
Danish: AZOPT er ikke vurderet hos patienter med snævervinklet glaukom, og det bør ikke anvendes til disse patienter.
English: AZOPT 10 mg/ml eye drops, suspension brinzolamide
Danish: AZOPT 10 mg/ml øjendråber, suspension brinzolamid
English: Uncommon: motor dysfunction, amnesia, dizziness, paraesthesia, headache
Danish: Ikke almindelig: motorisk dysfunktion, amnesi, svimmelhed, paræstesi, hovedpine
English: Common side effects (may affect up to 1 in 10 people)
Danish: Almindelige bivirkninger (kan forekomme hos mellem 1 ud af 10 personer )
English: 4 weeks after first opening.
Danish: 4 uger efter anbrud.
English: The events were mild and did not affect the overall discontinuation rates in the studies (see also section 4.8).
Danish: Bivirkningerne var milde og påvirkede ikke den totale andel af patienter, der afbrød behandling (se også pkt.
English: If you get too much in your eyes, rinse it all out with warm water.
Danish: Hvis du har brugt for meget AZOPT Skyl dit øje med lunkent vand.
English: • Put the bottle cap back on firmly immediately after use
Danish: • Skru hætten omhyggeligt på flasken umiddelbart efter brug.
English: AZOPT contains benzalkonium chloride which may cause eye irritation and is known to discolour soft contact lenses.
Danish: AZOPT indeholder benzalkoniumchlorid, der kan medføre øjenirritation og misfarvning af bløde kontaktlinser.
English: Following topical ocular administration, brinzolamide is absorbed into the systemic circulation.
Danish: Ved topikal okulær administration absorberes brinzolamid over i det systemiske kredsløb.
English: CARTON FOR SINGLE BOTTLE, 5 ml, 10 ml + CARTON FOR 3 x 5 ml BOTTLES
Danish: ÆSKE TIL ENKELT FLASKE, 5 ml, 10 ml + ÆSKE TIL 3 x 5 ml FLASKER
English: - if you are taking other sulphonamide medicines - if you have a specific form of glaucoma in which the pressure inside the eye rises due to deposits that block fluid draining out (pseudoexfoliative glaucoma or pigmentary glaucoma) or a specific form of glaucoma in which the pressure inside the eye (sometimes rapidly) rises because the eye bulges forward and blocks fluid draining out (narrow-angle glaucoma)
Danish: som blokerer for afløb af væske (pseudoeksfoliativt glaukom eller pigmentglaukom), eller en særlig form for grøn stær, hvor trykket inde i øjet stiger (nogle gange hurtigt), fordi regnbuehinden buler frem og blokerer for afløb af væske (snævervinklet glaukom).
English: The IOP-reducing effect of AZOPT as adjunctive therapy to the prostaglandin analogue travoprost was studied.
Danish: AZOPTs IOP-sænkende effekt som supplerende terapi til prostaglandinanalogen travoprost er blevet undersøgt.
English: AZOPT has not been studied in patients with hepatic impairment and is therefore not recommended in such patients.
Danish: AZOPT øjendråber er ikke undersøgt hos patienter med nedsat leverfunktion og anbefales derfor ikke til denne patientgruppe.
English: If a dose is missed, treatment should be continued with the next dose as planned.
Danish: Hvis patienten har glemt at tage en dosis, skal han/hun fortsætte med den sædvanlige doseringsplan.
English: Instruct patients to keep the bottle tightly closed when not in use.
Danish: Patienten skal instrueres i at lukke flasken tæt efter brug.
English: The use of AZOPT is not recommended during pregnancy or breast-feeding.
Danish: AZOPT må ikke anvendes under graviditet og amning.