FrancophonIA/ELRC3.0 huggingface dataset:
English: Frequency de novo PI substitution (n=35)
Slovenian: Nova substitucija zaviralca proteaz (n=35)
English: Symptoms of gallbladder problems may include pain in the right or middle upper stomach area, nausea, vomiting, fever or yellowing your skin or the white part of your eyes.
Slovenian: Simptomi težav z žolčnikom lahko vključujejo bolečino v desnem ali srednjem predelu trebuha, siljenje na bruhanje, bruhanje, zvišano telesno temperaturo ali rumeno obarvanje kože ali očesnih beločnic.
English: Quinidine has a narrow therapeutic window and is contraindicated due to potential inhibition of CYP3A by atazanavir.
Slovenian: Kinidin ima ozko terapevtsko okno, njegova uporaba pa je kontraindicirana zaradi možne inhibicije CYP3A z atazanavirjem.
English: - The other ingredients are lactose monohydrate (see section 2, ‘Atazanavir Mylan contains lactose'), crospovidone, magnesium stearate.
Slovenian: - Druge sestavine zdravila so laktoza monohidrat (glejte poglavje 2 'Zdravilo Atazanvir Mylan vsebuje laktozo) krospovidon, magnezijev stearat.
English: In clinical studies, atazanavir (with or without ritonavir) has been shown to induce dyslipidaemia to a lesser extent than comparators.
Slovenian: V kliničnih študijah so ugotovili, da atazanavir (z ritonavirjem ali brez) povzroča dislipidemijo v manjši meri kot primerjalna zdravila.
English: Parameter ATV/RTV
Slovenian: ATV/RTV
English: • peripheral neuropathy (numbness, weakness, tingling or pain in the arms and legs)
Slovenian: • periferna nevropatija (odrevenelost, oslabelost, zbadanje ali bolečina v rokah ali nogah);
English: The use of Atazanavir Mylan with ritonavir may be considered during pregnancy only if the potential benefit justifies the potential risk.
Slovenian: Med nosečnostjo se sme zdravilo Atazanavir Mylan z ritonavirjem uporabljati le, če možne koristi upravičujejo možna tveganja.
English: Efficacy Atazanavir/ritonavir is not effective in viral strains harbouring multiple mutations of resistance.
Slovenian: Atazanavir/ritonavir ni učinkovit pri virusnih sevih, pri katerih je prisotnih več mutacij, ki vodijo v odpornost.
English: • lurasidone (used to treat schizophrenia).
Slovenian: • lurasidon (uporabljamo ga za zdravljenje shizofrenije),
English: Patients should be closely monitored for tenofovir disoproxil fumarate-associated adverse reactions, including renal disorders.
Slovenian: Bolnike je treba skrbno nadzirati glede pojava neželenih učinkov dizoproksiltenofovirijevega fumarata, vključno z motnjami delovanja ledvic.
English: • the need to consider that - co-administration of voriconazole and atazanavir without ritonavir may affect atazanavir concentrations - co-administration of fluticasone and atazanavir without ritonavir may increase fluticasone concentrations relative to fluticasone given alone - if an oral contraceptive is administered with atazanavir without ritonavir, it is recommended that the oral contraceptive contain no more than 30 µg of ethinyloestradiol - no dose adjustment of lamotrigine is required
Slovenian: • upoštevati je treba - pri sočasni uporabi vorikonazola in atazanavirja brez ritonavirja se lahko pojavi vpliv na koncentracije atazanavirja - pri sočasni uporabi flutikazona in atazanavirja brez ritonavirja se lahko povečajo koncentracije flutikazona v primerjavi z uporabo flutikazona samega - če bolnica uporablja peroralni kontraceptiv skupaj z atazanavirjem brez ritonavirja, je priporočljivo, da peroralni kontraceptiv ne vsebuje več kot 30 µg etinilestradiola - odmerka lamotrigina ni treba prilagajati
English: In in vivo studies in rats, atazanavir did not induce micronuclei in bone marrow, DNA damage in duodenum (comet assay), or unscheduled DNA repair in liver at plasma and tissue concentrations exceeding those that were clastogenic in vitro.
Slovenian: V študijah in vivo na podganah atazanavir ni izzval nastanka mikrojeder v kostnem mozgu, poškodb DNA v dvanajstniku (kometni test) ali nepredvidenega popravila DNA v jetrih ob plazemskih in tkivnih koncentracijah, ki so presegale koncentracije, klastogene in vitro.
English: • Periodic Safety Update Reports
Slovenian: ▪ Redno posodobljena poročila o varnosti zdravila (PSUR)
English: Combination of the PDE5 inhibitor sildenafil when used for the treatment of pulmonary arterial hypertension (PAH) only (see section 4.5).
Slovenian: Sočasna uporaba zaviralca PDE5 sildenafila, vendar le za zdravljenje pljučne arterijske hipertenzije (PAH) (glejte poglavje 4.5).
English: Your doctor will discuss with you which combination of these medicines with Atazanavir Mylan is best for you.
Slovenian: Z zdravnikom se posvetujte, kakšna kombinacija anti-HIV zdravil z zdravilom Atazanavir Mylan bi bila za vas najboljša.
English: Atazanavir Mylan, co-administered with low dose ritonavir, is indicated for the treatment of HIV-1 infected adults and paediatric patients 6 years of age and older in combination with other antiretroviral medicinal products (see section 4.2).
Slovenian: Zdravilo Atazanavir Mylan je ob sočasni uporabi majhnih odmerkov ritonavirja indicirano za zdravljenje s HIV-1 okuženih odraslih in pediatričnih bolnikov, starih 6 let ali več, v kombinaciji z drugimi protiretrovirusnimi zdravili (glejte poglavje 4.2).
English: Atazanavir should be administered 2 hours before or 1 hour after antacids or buffered medicinal products.
Slovenian: atazanavir je treba uporabljati 2 uri pred ali 1 uro po uporabi antacida ali zdravila, ki vsebuje pufer.
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Slovenian: Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom.
English: Take Atazanavir Mylan capsules with food (a meal or a substantial snack).
Slovenian: Kapsule Atazanavir Mylan vzemite skupaj s hrano (s kosilom ali z obilnejšim obrokom).
English: Desacetyl-diltiazem Cmin ↑121%
Slovenian: dezacetil-diltiazem Cmin ↑121 %
English: ANTIPSYCHOTICS Quetiapine
Slovenian: ANTIPSIHOTIKI kvetiapin
English: Atazanavir is metabolised and eliminated primarily by the liver.
Slovenian: Atazanavir se večinoma presnavlja in izloča v jetrih.
English: • triazolam and oral (taken by mouth) midazolam (used to help you sleep and/or to relieve anxiety).
Slovenian: • triazolam in peroralne oblike (ki se jih jemlje skozi usta) midazolama (uporabljamo jih kot pomoč pri težavah s spanjem in/ali za ublažitev tesnobe),
English: Ritonavir is used as a booster of atazanavir pharmacokinetics (see sections 4.5 and 5.1).
Slovenian: Ritonavir se uporablja kot stopnjevalec farmakokinetike atazanavirja (glejte poglavji 4.5 in 5.1).
English: • disorientation, amnesia (loss of memory), dizziness, somnolence (sleepiness), abnormal dream
Slovenian: • dezorientiranost, amnezija (izguba spomina), omotica, somnolenca (zaspanost), neobičajne sanje;
English: If indicated, elimination of unabsorbed atazanavir should be achieved by emesis or gastric lavage.
Slovenian: Če je indicirana odstranitev neabsorbiranega atazanavirja, je treba sprožiti bruhanje ali izprati želodec.
English: uncommon: depression, disorientation, anxiety, insomnia, sleep disorder, abnormal dream
Slovenian: občasni: depresija, dezorientiranost, anksioznost, nespečnost, motnje spanja, nenormalne sanje
English: Atazanavir Mylan is an antiviral (or antiretroviral) medicine.
Slovenian: Atazanavir Mylan je zdravilo, ki deluje proti virusom (ali retrovirusom).
English: Co-administration of atazanavir/ritonavir with boceprevir resulted in lower exposure of atazanavir which may be associated with lower efficacy and loss of HIV control.
Slovenian: Sočasna uporaba atazanavirja/ritonavirja z boceprevirjem je povzročila zmanjšanje izpostavljenosti atazanavirju, kar je lahko povezano s slabšo učinkovitostjo in izgubo nadzora nad virusom HIV.
English: The M184V substitution in reverse transcriptase, which confers resistance to lamivudine and emtricitabine, was detected in 2 subjects in the unboosted atazanavir and 1 subject in the atazanavir + ritonavir group.
Slovenian: Substitucijo M184V reverzne transkriptaze, ki je povezana z odpornostjo proti lamivudinu in emtricitabinu, so zasledili pri 2 bolnikih v skupini z atazanavirjem brez okrepitve in 1 bolniku v skupini z atazanavirjem + ritonavirjem.
English: Of the 60 isolates from patients treated with either atazanavir or atazanavir + ritonavir, 18 (30%) displayed the I50L phenotype previously described in naive patients.
Slovenian: Od 60 izolatov bolnikov, zdravljenih z atazanavirjem ali atazanavirjem + ritonavirjem, so pri 18 (30 %) odkrili fenotip I50L, prej opisan pri predhodno protiretrovirusno nezdravljenih bolnikih.
English: Four subjects in the unboosted atazanavir group and 2 in the atazanavir + ritonavir group had HIV RNA > 500 copies/ml during the maintenance phase.
Slovenian: Štirje bolniki v skupini z atazanavirjem brez okrepitve in 2 bolnika v skupini z atazanavirjem + ritonavirjem so med vzdrževalnim obdobjem zdravljenja imeli vrednost HIV RNA > 500 kopij/ml.
English: Patients with coexisting conditions
Slovenian: Bolniki s sočasnimi boleznimi
English: Of importance, many studies were conducted with unboosted atazanavir, which is not the recommended regimen of atazanavir (see section 4.4).
Slovenian: Pomembno je izpostaviti, da so bile številne študije izvedene brez okrepitve farmakokinetike atazanavirja, kar pa ni priporočen režim uporabe atazanavirja (glejte poglavje 4.4).
English: • alopecia (unusual hair loss or thinning), pruritus (itching)
Slovenian: • alopecija (neobičajno izpadanje ali redčenje las), pruritus (srbenje);
English: Consult the dosing table for the specific formulation (see relevant Summary of Product Characteristics).
Slovenian: Glejte tabelo za odmerjanje za posamezno farmacevtsko obliko (glejte povzetek glavnih značilnosti zdravila za ustrezno farmacevtsko obliko).
English: Close monitoring of patient's virologic response should be exercised.
Slovenian: Pri bolniku je treba skrbno spremljati virusni odziv.
English: Due to carbamazepine inducing effect, a reduction in atazanavir exposure cannot be ruled out.
Slovenian: Zaradi inducirajočega učinka karbamazepina zmanjšanja izpostavljenosti atazanavirju ne moremo izključiti.
English: 50 to <100 cells/mm
Slovenian: 50 do <100 celic/mm
English: Atazanavir (without ritonavir) has been studied in adult subjects with moderate-to-severe hepatic impairment (14 Child-Pugh Class B and 2 ChildPugh Class C subjects) after a single 400 mg dose.
Slovenian: Uporabo atazanavirja (brez ritonavirja) so raziskovali pri odraslih osebah z zmerno do hudo okvaro jeter (14 oseb Child-Pugh B in 2 osebi ChildPugh C) po enkratnem 400 mg odmerku.
English: This decrease in atazanavir exposure might negatively impact the efficacy of atazanavir.
Slovenian: To zmanjšanje izpostavljenosti atazanavirju lahko vpliva negativno na učinkovitost atazanavirja.
English: • simvastatin and lovastatin (used to lower blood cholesterol).
Slovenian: • simvastatin in lovastatin (uporabljamo ju za zniževanje holesterola v krvi),
English: The atazanavir/ritonavir arm showed similar (non-inferior) antiviral efficacy compared to the lopinavir/ritonavir arm, as assessed by the proportion of patients with HIV RNA < 50 copies/ml at week 48 (Table 5).
Slovenian: V skupini, ki je prejemala atazanavir/ritonavir, je bila protivirusna učinkovitost podobna (ni bila manjša) kot v skupini, ki je prejemala lopinavir/ritonavir, kar je bilo ovrednoteno z deležem bolnikov z vrednostjo HIV RNA < 50 kopij/ml v 48. tednu (preglednica 5).
English: If you develop signs or symptoms of kidney stones (pain in your side, blood in your urine, pain when you urinate), please inform your doctor immediately.
Slovenian: Če se pojavijo znaki ali simptomi ledvičnih kamnov (bolečina v ledvenem predelu, krvav urin, boleče uriniranje), o tem nemudoma obvestite zdravnika.
English: ACID REDUCING AGENTS H2-Receptor antagonists
Slovenian: ZDRAVILA ZA ZMANJŠEVANJE KISLOSTI ŽELODČNEGA SOKA Antagonisti histaminskih receptorjev H2
English: Frequency de novo PI substitution (n=26)
Slovenian: Nova substitucija zaviralca proteaz (n=26)
English: Data on withdrawal of ritonavir from atazanavir boosted regimen (see also section 4.4) Study 136 (INDUMA)
Slovenian: Podatki o odtegnitvi ritonavirja iz okrepljenega režima z atazanavirjem (glejte tudi poglavje 4.4) Študija 136 (INDUMA)
English: Excipient(s) with known effect
Slovenian: Pomožna snov z znanim učinkom:
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART - 'Combination antiretroviral therapy') ali obojim.
English: Itraconazole, like ketoconazole, is a potent inhibitor as well as a substrate of CYP3A4.
Slovenian: itrakonazol itrakonazol je podobno kot ketokonazol močan zaviralec in tudi substrat za CYP3A4.
English: It is recommended that the International Normalised Ratio (INR) be monitored carefully during treatment with atazanavir, especially when commencing therapy.
Slovenian: Med zdravljenjem z atazanavirjem priporočamo skrben nadzor internacionalnega normaliziranega razmerja (INR), še posebej ob uvedbi zdravljenja.
English: Administration of atazanavir with ritonavir with either a light or a high-fat meal decreased the coefficient of variation of AUC and Cmax by approximately 25% compared to the fasting state.
Slovenian: Pri uporabi atazanavirja z ritonavirjem skupaj z obrokom, bodisi lahkim, bodisi bogatim z maščobami, se je koeficient variacije AUC in Cmax zmanjšal za približno 25 % v primerjavi z uporabo na tešče.
English: Deutschland Mylan dura GmbH Tel: +49-(0) 6172 888 01
Slovenian: Mylan dura GmbH Tel: +49-(0) 6172 888 01
English: Raltegravir C12hr↑ 77%
Slovenian: raltegravir C12ur ↑77 %
English: Neither metabolite demonstrated in vitro antiviral activity.
Slovenian: Nobeden od metabolitov in vitro ni imel protivirusnega učinka.
English: 100 to <200 cells/mm
Slovenian: 100 do <200 celic/mm
English: Following a single 400 mg dose of
Slovenian: Po enkratnem 400-mg odmerku s
English: Studies conducted in HIV-infected patients.
Slovenian: Študije, izvedene pri bolnikih, okuženih z virusom HIV.
English: Through 96 weeks of treatment, mean HIV RNA changes from baseline for atazanavir + ritonavir and lopinavir + ritonavir met criteria for non-inferiority based on observed cases.
Slovenian: Pri 96-tedenskem zdravljenju so srednje spremembe vrednosti HIV RNA od izhodišča za atazanavir + ritonavir in lopinavir + ritonavir zadostile merilom neinferiornosti na podlagi opazovanih primerov.
English: If atazanavir is co-administered with irinotecan, patients should be closely monitored for adverse events related to irinotecan.
Slovenian: Če se atazanavir uporablja skupaj z irinotekanom, je bolnika treba skrbno nadzirati glede pojava neželenih učinkov irinotekana.
English: Paediatric patients (at least 3 months of age and weight at least 5 kg): Other formulations of this medicine may be available for paediatric patients at least 3 months of age and weighing at least 5 kg (see relevant Summary of Product Characteristics for alternative forms).
Slovenian: Pediatrični bolniki (stari najmanj 3 mesece in s telesno maso najmanj 5 kg): Za pediatrične bolnike, stare najmanj 3 mesece in s telesno maso najmanj 5 kg, so na voljo druge oblike tega zdravila (glejte povzetek glavnih značilnosti zdravila alternativne oblike zdravila).
English: • salmeterol (used to treat asthma)
Slovenian: • salmeterol (zdravilo za zdravljenje astme),
English: Didanosine should be taken at the fasted state 2 hours after atazanavir taken with food.
Slovenian: Didanozin mora bolnik jemati na prazen želodec 2 uri po atazanavirju, ki ga vzame skupaj s hrano.
English: Subjects with at least one functional CYP2C19 allele.
Slovenian: Osebe z vsaj enim funkcionalnim alelom CYP2C19.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occurs many months after initiation of treatment.
Slovenian: Poročajo, da se med imunsko reaktivacijo lahko pojavijo tudi avtoimunske bolezni (kot je Gravesova bolezen in avtoimunski hepatitis); čas do njihovega nastanka je spremenljiv, zato se lahko pojavijo tudi več mesecev po začetku zdravljenja.
English: Based on data for other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally.
Slovenian: Na osnovi podatkov za druge zaviralce CYP3A4 pričakujemo, da se bodo plazemske koncentracije midazolama pri peroralni uporabi midazolama pomembno povečale.
English: During HIV therapy there may be an increase in weight and in levels of blood lipids and glucose.
Slovenian: Med zdravljenjem HIV lahko pride do povečanja telesne mase in vrednosti lipidov in glukoze v krvi.
English: • that co-administration is not recommended with tenofovir, boceprevir, carbamazepine, phenytoin, phenobarbital, proton pump inhibitors, and buprenorphine.
Slovenian: • sočasna uporaba ni priporočljiva s tenofovirjem, boceprevirjem, karbamazepinom, fenitoinom, fenobarbitalom, zaviralci protonske črpalke in buprenorfinom.
English: Talk to your doctor or pharmacist before taking Atazanavir Mylan and make sure your doctor knows:
Slovenian: Pred začetkom jemanja zdravila Atazanavir Mylan se posvetujte z zdravnikom ali farmacevtom in se prepričajte, da vaš zdravnik ve:
English: • grazoprevir-containing products, including elbasvir/grazoprevir fixed dose combination (used to treat chronic hepatitis C infection).
Slovenian: • zdravila, ki vsebujejo grazoprevir, vključno s fiksno kombinacijo elbasvir/grazoprevir (uporabljajo se za zdravljenje kronične okužbe z virusom hepatitisa C).
English: If you notice any symptoms of infection, please inform your doctor immediately.
Slovenian: Če opazite kakršne koli znake okužbe, o tem takoj obvestite zdravnika.
English: During in vitro studies, cloned human cardiac potassium channel (hERG), was inhibited by 15% at a concentration (30 μM) of atazanavir corresponding to 30 fold the free drug concentration at Cmax in humans.
Slovenian: Med študijami in vitro je prišlo do 15-odstotnega zavrtja kloniranih človeških srčnih kanalov za kalij, hERG, pri koncentraciji atazanavirja (30 μM), ki ustreza 30-kratni koncentraciji nevezane oblike učinkovine pri Cmax pri človeku.
English: 300 mg tenofovir disoproxil fumarate is equivalent to 245 mg tenofovir disoproxil.
Slovenian: 300 mg dizoproksiltenofovirijevega fumarata, kar ustreza 245 mg dizoproksiltenofovirata.
English: Select substitutions include any change at positions L10, K20, L24, V32, L33, M36, M46, G48, I50, I54, L63, A71, G73, V82, I84, and L90 (0-2, 3, 4 or more) at baseline.
Slovenian: Izbrane substitucije vključujejo katero koli spremembo na pozicijah L10, K20, L24, V32, L33, M36, M46, G48, I50, I54, L63, A71, G73, V82, I84 in L90 (0-2, 3, 4 ali več) ob izhodišču.
English: When given with atazanavir, the recommended dose of rifabutin is 150 mg 3 times per week on set days (for example MondayWednesday-Friday).
Slovenian: Pri sočasni uporabi v kombinaciji z atazanavirjem je priporočeni odmerek rifabutina 150 mg 3-krat na teden na določene dneve (na primer ponedeljek-sredapetek).
English: Concentrations of atazanavir (when given with ritonavir) were not significantly affected.
Slovenian: Koncentracije atazanavirja (pri sočasni uporabi z ritonavirjem) se niso pomembneje spremenile.
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Slovenian: Pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - 'Combination antiretroviral therapy') nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične patogene in povzroči resna klinična stanja ali poslabšanje simptomov.
English: During attempts to overcome the decreased exposure by increasing the dose of atazanavir or other protease inhibitors with ritonavir, a high frequency of liver reactions was seen.
Slovenian: Ko so manjšo izpostavljenost poskušali nadomestiti z zvečanjem odmerka atazanavirja ali drugih zaviralcev proteaz v kombinaciji z ritonavirjem, so poročali o večji pogostnosti jetrnih neželenih učinkov.
English: The effects of hepatic impairment on the pharmacokinetics of atazanavir after a 300 mg dose with ritonavir have not been studied.
Slovenian: Vpliv okvare jeter na farmakokinetiko atazanavirja po odmerku 300 mg z ritonavirjem ni raziskan.
English: No dose adjustment required for raltegravir.
Slovenian: Odmerka raltegravirja ni treba prilagajati.
English: • Liver problems may uncommonly happen.
Slovenian: • Občasno lahko pride do težav z jetri.
English: In a fertility and early embryonic development study in rats, atazanavir altered oestrus cycling with no effects on mating or fertility.
Slovenian: V študijah plodnosti in zgodnjega embrionalnega razvoja pri podganah je atazanavir spremenil estrusni ciklus brez učinkov na parjenje in plodnost.
English: The dose of Atazanavir Mylan capsules for children is calculated by body weight and is taken once daily with food and 100 mg ritonavir as shown below:
Slovenian: Odmerek kapsul Atazanavir Mylan za otroke se izračuna na osnovi telesne mase in se ga jemlje enkrat na dan skupaj s hrano in 100 mg ritonavirja, kot je prikazano v spodnji preglednici:
English: If a higher dose of an H2-receptor antagonist is required (e.g., famotidine 40 mg twice daily or equivalent) an increase of the atazanavir/ritonavir dose from 300/100 mg to 400/100 mg can be considered.
Slovenian: Če je potreben večji odmerek antagonista histaminskih receptorjev H2 (npr. famotidin 40 mg dvakrat na dan ali ekvivalenten odmerek), je treba razmisliti o povečanju odmerka atazanavirja/ritonavirja iz 300 mg/100 mg na 400 mg/100 mg.
English: PI major L24I, D30N, V32I, L33F, M46IL, I47AV, G48V, I50LV, F53LY,I54ALMSTV, L76V, V82AFLST, I84V, N88DS, L90M; PI minor: L10CFIRV, V11I, E35G, K43T, Q58E, A71ILTV, G73ACST, T74P, N83D, L89V.
Slovenian: Glavne substitucije zaviralcev proteaz L24I, D30N, V32I, L33F, M46IL, I47AV, G48V, I50LV, F53LY, I54ALMSTV, L76V, V82AFLST, I84V, N88DS, L90M; redkejše substitucije zaviralcev proteaz: L10CFIRV, V11I, E35G, K43T, Q58E, A71ILTV, G73ACST, T74P, N83D, L89V.
English: When atazanavir/ritonavir is co-administered with either phenytoin or phenobarbital, a dose adjustment of phenytoin or phenobarbital may be required.
Slovenian: Če se atazanavir/ritonavir uporablja sočasno bodisi s fenitoinom bodisi s fenobarbitalom, bo odmerek fenitoina ali fenobarbitala morda treba prilagoditi.
English: Concomitant use of salmeterol and Atazanavir Mylan may result in increased cardiovascular adverse events associated with salmeterol.
Slovenian: Pri sočasni uporabi salmeterola in zdravila Atazanavir Mylan se lahko poveča pojavnost kardiovaskularnih neželenih učinkov salmeterola.
English: Eleven subjects (13%) in the unboosted atazanavir group and 6 (7%) in the atazanavir + ritonavir group, had virologic rebound.
Slovenian: Pri 11 bolnikih (13 %) v skupini z atazanavirjem brez okrepitve in 6 bolnikih (7 %) v skupini z atazanavirjem + ritonavirjem je prišlo do virusnega rebounda.
English: Ritonavir Dose* once daily (mg)
Slovenian: Odmerek ritonavirja* enkrat na dan (mg)