FrancophonIA/ELRC3.0 huggingface dataset:
English: VIRACEPT oral powder also contains sucrose.
Slovenian: Peroralni prašek VIRACEPT vsebuje tudi saharozo.
English: You should monitor your child to assure that the recommended number of tablets are taken at each dose with meals, for each weight band.
Slovenian: Spremljati morate, da bo vaš otrok v vsakem območju telesne mase vzel priporočeno število tablet pri vsakem odmerku z obroki.
English: Weight loss and general physical decline was observed in monkeys together with general evidence of gastrointestinal toxicity.
Slovenian: Opicam se je zmanjšala masa in pojavilo se je splošno telesno propadanje skupaj s splošnimi znaki toksičnosti v prebavilih.
English: St. John's wort may persist for at least 2 weeks after cessation of treatment.
Slovenian: Induktivni učinek šentjanževke na encime lahko traja vsaj še 2 tedna po prekinitvi zdravljenja s šentjanževko.
English: The multi-dose pharmacokinetics of nelfinavir have not been studied in HIV-positive patients with hepatic insufficiency.
Slovenian: Farmakokinetike večkratnega odmerjanja nelfinavirja pri HIV pozitivnih bolnikih z jetrno okvaro niso proučevali.
English: Chronic nelfinavir treatment of rats has been demonstrated to produce effects consistent with enzyme induction, which predisposed rats, but not humans, to thyroid neoplasms.
Slovenian: Pri podganah je dolgotrajno jemanje nelfinavirja povzročilo učinke v skladu z encimsko indukcijo, kar pri podganah, ne pa tudi pri ljudeh, poveča predispozicijo za novotvorbe ščitnice.
English: Nelfinavir AUC ↑ 83%
Slovenian: AUC nelfinavirja ↑ 83 %
English: Body weight of the patient in
Slovenian: Telesna masa bolnika v kg
English: The signs may include joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Slovenian: Znaki osteonekroze lahko vključujejo togost sklepa, bolečine (zlasti v kolku, kolenu in rami) in težave z gibljivostjo.
English: • Amiodarone or quinidine (for an uneven heart beat)
Slovenian: • amiodaron ali kinidin (za nepravilne srčne utripe),
English: They should be swallowed whole and taken with a meal.
Slovenian: Tablete je treba pogoltniti cele in skupaj z obrokom.
English: The prescriber should advise the patient to use the handle of the second scoop to scrape off extra powder and obtain a level scoop.
Slovenian: Zdravnik naj bolnika pouči, kako naj uporabi ročaj druge merice za odstranitev presežka praška s prve merice, da bo izravnal njeno površino.
English: Specific dose recommendations for nelfinavir cannot be made based on the results of this study.
Slovenian: Na podlagi rezultatov te študije ni mogoče narediti posebnih priporočil za odmerjanje nelfinavirja.
English: • Methadone (for drug dependence)
Slovenian: • metadon (za zdravljenje zasvojenosti z opijati),
English: • Do not stop taking this medicine without talking to your doctor first.
Slovenian: • Zdravila ne smete prenehati jemati preden se posvetujete z vašim zdravnikom.
English: In a second study, healthy volunteers received single doses of 1250 mg VIRACEPT (5 x 250 mg tablets) under fasted or fed conditions (two meals with different fat content).
Slovenian: V drugi študiji so zdravi prostovoljci prejeli 1250 mg enkratni odmerek zdravila VIRACEPT (5x 250 mg tablete) na tešče ali po obroku (dva obroka z različno vsebnostjo maščob).
English: • Cases of diabetes mellitus or increased blood sugar levels have been reported in patients receiving this treatment or another protease inhibitor.
Slovenian: • pri bolnikih, ki so se zdravili s to terapijo ali z drugimi zaviralci proteaz so poročali o sladkorni bolezni ali povišanem sladkorju v krvi.
English: At week 48, 63 % nelfinavir and 75 % lopinavir/ritonavir patients had HIV-1 RNA < 400 copies/ml, whereas 52 % nelfinavir and 67 % lopinavir/ritonavir patients had HIV-1 RNA <50 copies/ml (intent-to-treat, missing = failure).
Slovenian: V 48. tednu je 63 % bolnikov, zdravljenih z nelfinavirjem, in 75 % bolnikov, zdravljenih z lopinavirjem/ritonavirjem, imelo HIV-1 RNK < 400 kopij/ml, medtem ko je 52 % bolnikov, zdravljenih z nelfinavirjem, in 67 % bolnikov, zdravljenih z lopinavirjem/ritonavirjem, imelo HIV-1 RNK < 50 kopij/ml (namen zdravljenja, odsotnost = neuspeh).
English: Parenteral midazolam should be coadministered with nelfinavir in an intensive care unit to ensure close clinical monitoring.
Slovenian: Če se nelfinavir daje sočasno s parenteralno obliko midazolama, se mora to izvesti v enoti za intenzivno nego, ki zagotavlja natančno klinično spremljanje.
English: As these data come from the spontaneous reporting system, the frequency of the adverse reactions is unknown: hypertriglyceridemia, anaemia, blood lactic acid increased, and pneumonia.
Slovenian: Pogostnost teh neželenih učinkov ni znana, saj so podatki zbrani s spontanim poročanjem: hipertrigliceridemija, anemija, povečana koncentracija mlečne kisline v krvi in pljučnica.
English: The table provides a schedule assuring that the appropriate total daily dose of Viracept is taken each day based on the child's weight.
Slovenian: Preglednica prikazuje načrt, ki zagotavlja, da otrok vsak dan dobi ustrezen celokupni dnevni odmerek zdravila Viracept glede na njegovo telesno maso.
English: This helps make your medicine work as well as it can.
Slovenian: To omogoča, najboljše delovanje zdravila.
English: No dosage adjustment for needed for either product
Slovenian: Ni potrebno prilagajati odmerka za nobeno od zdravil.
English: At week 48, non-inferiority was shown with 68 % of patients in the group treated with nelfinavir and 69 % patients treated with fosamprenavir/ritonavir having plasma HIV-1 RNA <400 copies/ml whereas 53 % in the nelfinavir and 55 % in the fosamprenavir/ritonavir patients had HIV-1 RNA <50 copies/ml (intent-to-treat, rebound/discontinuation = failure).
Slovenian: V 48. tednu je 68 % bolnikov v skupini, zdravljeni z nelfinavirjem, in 69 % bolnikov, zdravljenih s fosamprenavirjem/ritonavirjem, imelo koncentracijo HIV-1 RNK v plazmi < 400 kopij/ml, kar je kazalo na enakost med skupinama, medtem ko je imelo 53 % bolnikov v skupini, zdravljeni z nelfinavirjem, in 55 % bolnikov v skupini, zdravljeni s fosamprenavirjem/ritonavirjem, HIV-1 RNK < 50 kopij/ml (namen zdravljenja, ponoven pojav/ukinitev = neuspeh).
English: 18 to 22 kg*
Slovenian: 18 do 22 kg*
English: - Contains potassium: 50.0 mg of dibasic potassium phosphate corresponding to 22.5 mg of See section 4.4
Slovenian: - vsebuje kalij: 50,0 mg kalijevega hidrogenfosfata ustreza 22,5 mg kalija na gram peroralnega
English: VIRACEPT film-coated tablets are provided in HDPE plastic bottles containing either 270 or 300 tablets, fitted with HDPE child resistant closures with polyethylene liners.
Slovenian: Filmsko obložene tablete VIRACEPT so na voljo v plastičnih steklenicah HDPE, opremljenih z za otroke varnimi HDPE zaporkami s polietilensko podlogo po 270 ali 300 tablet.
English: Administration of activated charcoal may also be used to aid removal of unabsorbed nelfinavir.
Slovenian: Neabsorbirani nelfinavir je mogoče odstraniti tudi z dajanjem aktivnega oglja.
English: Median baseline HIV-1 RNA was 4.98 log10 copies/ml and 5.01 log10 copies/ml in the nelfinavir and lopinavir/ritonavir treatment groups respectively.
Slovenian: Mediana začetne vrednosti HIV-1 RNK je bila 4,98 log10 kopij/ml v skupini, zdravljeni z nelfinavirjem, in 5,01 log10 kopij/ml v skupini, zdravljeni z lopinavirjem/ritonavirjem.
English: By contrast, no effects suggesting prolongation of the QT-interval of the ECG were observed at similar doses in dogs or in isolated cardiac tissue.
Slovenian: V nasprotju pa pri podobnih odmerkih pri psih ali v izoliranem srčnem tkivu niso opazili vplivov na podaljšanje intervala Q-T v EKG-ju.
English: Do not take Viracept if any of the above apply to you.
Slovenian: Ne jemljite zdravila Viracept, če se karkoli od naštetega nanaša na vas.
English: Increase in Nelfinavir AUC, Cmax and Tmax in Fed Low Fat (20%) versus High fat (50%) State Relative to Fasted State Following 1250 mg VIRACEPT (5 x 250 mg tablets) Number of
Slovenian: Povečanje AUC, Cmax in Tmax nelfinavirja po obroku z nizko vsebnostjo maščob (20 %) v primerjavi z obrokom z visoko vsebnostjo maščob (50 %) in v primerjavi z uživanjem zdravila na tešče po 1250 mg odmerku zdravila VIRACEPT (5 x 250 mg tablete) Število kcal
English: Median baseline CD4+ cell count was 232 cells/mm3
Slovenian: Mediana začetnega števila celic CD4+ je bila 232 celic/mm3 v obeh skupinah.
English: Follow the instructions carefully to get the most benefit from Viracept.
Slovenian: Da bi dosegli najboljše učinkovanje zdravila Viracept, pozorno sledite navodilom.
English: • Phenytoin (for fits or epilepsy)
Slovenian: • fenitoin (za krče ali epilepsijo),
English: The mean decrease in plasma HIV RNA using a PCR assay (< 400 copies/ml) at 24 weeks was 2.33 log10 in patients receiving combination therapy with nelfinavir 750 mg TID, compared to 1.34 log10 in patients receiving zidovudine and lamivudine alone.
Slovenian: Srednje zmanjšanje HIV RNA v plazmi po 24 tednih, določeno z uporabo metode PCR (< 400 kopij/ml), je bilo 2,33 log10 pri bolnikih, ki so prejemali kombinirano zdravljenje s 750 mg nelfinavirja trikrat na dan, pri tistih, ki so jemali le zidovudin in lamivudin, pa 1,34 log10.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with nelfinavir is required.
Slovenian: Če je potrebno zdravljenje z nelfinavirjem, se pri bolnikih z normalno ledvično ali jetrno funkcijo priporoča znižanje odmerka kolhicina ali prekinitev zdravljenja s kolhicinom.
English: One or more viral protease mutations at amino acid positions 30, 35, 36, 46, 71, 77 and 88 were detected in > 10 % of patients with assessable isolates.
Slovenian: Pri > 10 % bolnikov z ocenljivimi izolati so opazili eno ali več mutacij virusne proteaze na aminokislinskih mestih 30, 35, 36, 46, 71, 77 in 88.
English: In patients, the nelfinavir AUC0-24 with 1250 mg BID administration was 52.8 ± 15.7 µg⋅h/ml (n=10) and with 750 mg TID administration was 43.6 ± 17.8 µg⋅h/ml (n=11).
Slovenian: Pri bolnikih, ki so prejemali 1250 mg nelfinavirja dvakrat na dan je bila AUC0-24 nelfinavirja 52,8 ± 15,7 μg•h/ml (n = 10), pri jemanju 750 mg trikrat na dan pa je bila 43,6 ± 17,8 μg•h/ml (n = 11).
English: Study M98-863 is a randomised, double blind trial of 653 antiretroviral-naïve patients investigating lopinavir/ritonavir (400/100 mg BID n=326) compared to nelfinavir (750 mg TID n=327), each in combination with lamivudine (150 mg twice daily) and stavudine (40 mg twice daily).
Slovenian: Študija M98-863 je randomizirana, preskušanje je dvojno slepo s 653 bolniki, ki še niso bili zdravljeni s protiretrovirusnimi učinkovinami, in preiskuje zdravljenje z lopinavirjem/ritonavirjem (400/100 mg dvakrat na dan, n = 326) v primerjavi z nelfinavirjem (750 mg trikrat na dan, n = 327), vsakega v kombinaciji z lamivudinom (150 mg dvakrat na dan) in stavudinom (40 mg dvakrat na dan).
English: • Atorvastatin or other statins (for lowering blood cholesterol)
Slovenian: • atorvastatin ali drugi statini (za znižanje holesterola v krvi),
English: In rats administration of 1000 mg/kg/day resulted in increased incidences of thyroid follicular cell adenoma and carcinoma, relative to those for controls.
Slovenian: Pri podganah se je pri dajanju 1000 mg/kg/dan pojavila zvečana pogostnost folikularnega celičnega adenoma in karcinoma ščitnice v primerjavi s kontrolno skupino.
English: Immune reactivation syndrome: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Slovenian: Sindrom imunske reaktivacije: pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - "combination antiretroviral therapy") nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične patogene in povzroči resna klinična stanja ali poslabšanje simptomov.
English: Patients aged 3 to 13 years: for children, the recommended starting dose is 50-55 mg/kg BID or if using a TID regimen, 25 - 35 mg/kg body weight per dose.
Slovenian: Bolniki, stari 3 do 13 let: za otroke je priporočeni začetni odmerek 50 do 55 mg/kg telesne mase dvakrat na dan ali 25 do 35 mg/kg telesne mase trikrat na dan.
English: It is recommended that the international normalized ratio (INR) be monitored carefully during treatment with VIRACEPT, especially when commencing therapy.
Slovenian: Med zdravljenjem z zdravilom VIRACEPT, še posebej pri uvajanju zdravljenja, se priporoča pozorno spremljanje mednarodnega umerjenega razmerja (IRN - International normalized ration).
English: • Calcium channel blockers such as bepridil (for heart problems)
Slovenian: • blokatorji kalcijevih kanalčkov, vključno z bepridilom (za bolezni srca),
English: Atorvastatin is less dependent on CYP3A4 for metabolism.
Slovenian: Presnova atorvastatina je manj odvisna od CYP3A4.
English: plus zidovudine and lamivudine or zidovudine and lamivudine, respectively.
Slovenian: zdravljeni le z zidovudinom in lamivudinom.
English: Rare (≥ 0.01 % - ≤ 0.1 %): new onset diabetes mellitus, or exacerbation of existing diabetes mellitus.
Slovenian: Redki (≥ 0,01 % - ≤ 0,1 %): pojav sladkorne bolezni ali poslabšanje že obstoječe sladkorne bolezni.
English: 5 g 6 g 7 g 8 g 10 g 11 g
Slovenian: 5 g 6 g 7 g 8 g 10 g 11 g 13 g 15 g
English: amprenavir, efavirenz or nevirapine
Slovenian: indinavir, sakvinavir in delavirdin, amprenavir, efavirenz ali nevirapin,
English: Patients with renal or hepatic impairment should not be given colchicine with nelfinavir (see section 4.4).
Slovenian: Bolnikom z ledvično ali jetrno okvaro se ne sme dati kolhicina z nelfinavirjem (glejte poglavje
English: Saquinavir AUC ↑ 392% Nelfinavir concentrations not measured
Slovenian: AUC sakvinavirja ↑ 392 % Koncentracija nelfinavirja ni bila merjena.
English: Taking this medicine • Take Viracept with a meal.
Slovenian: Jemanje zdravila • Zdravilo Viracept jemljite z obrokom.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with Viracept is not recommended.
Slovenian: Sočasno dajanje tadalafila za zdravljenje pljučne arterijske hipertenzije z zdravilom VIRACEPT se ne priporoča.
English: In one study, healthy volunteers received a single dose of 1250 mg of VIRACEPT (5x 250 mg tablets) under fasted or fed conditions (three meals with different caloric and fat contents).
Slovenian: Zdravi prostovoljci so v eni študiji prejeli 1250 mg enkratni odmerek zdravila VIRACEPT (5 x 250 mg tablete) na tešče ali po obroku (trije obroki z različnim številom kalorij in vsebnostjo maščob).
English: When administered concomitantly with nelfinavir, the patient's tolerability of bosentan should be monitored.
Slovenian: Kadar se daje sočasno z nelfinavirjem, se mora spremljati prenašanje bosentana.
English: Indinavir concentrations not measured
Slovenian: Koncentracija indinavirja ni bila merjena.
English: Diabetes mellitus and hyperglycaemia: New onset diabetes mellitus, hyperglycaemia or exacerbation of existing diabetes mellitus has been reported in patients receiving PIs.
Slovenian: Sladkorna bolezen in hiperglikemija: pri bolnikih, ki so jemali PI, so zasledili pojav sladkorne bolezni, hiperglikemijo ali poslabšanje obstoječe sladkorne bolezni.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains nelfinavir mesilate corresponding to 250 mg of nelfinavir.
Slovenian: KAKOVOSTNA IN KOLIČINSKA SESTAVA Vsaka filmsko obložena tableta vsebuje 250 mg nelfinavirja v obliki nelfinavirjevega mesilata.
English: If you take more Viracept than you should, talk to a doctor or pharmacist or go to a hospital straight away.
Slovenian: Če ste vzeli večji odmerek zdravila Viracept, kot bi smeli Če ste vzeli večji odmerek zdravila Viracept, kot bi smeli, se takoj posvetujte s svojim zdravnikom ali farmacevtom ali pojdite v bolnišnico.
English: Each film-coated tablet contains 292.25 mg of nelfinavir mesilate, equivalent to 250 mg nelfinavir as free base.
Slovenian: NAVEDBA ENE ALI VEČ ZDRAVILNIH UČINKOVIN Ena filmsko obložena tableta vsebuje 292,25 mg nelfinavirjevega mesilata, kar ustreza 250 mg nelfinavirja v obliki proste baze.
English: No treatment-related adverse reactions were seen in animal reproductive toxicity studies in rats at doses providing systemic exposure comparable to that observed with the clinical dose.
Slovenian: V študijah reproduktivne toksičnosti pri podganah pri odmerkih, ki zagotavljajo primerljivo sistemsko izpostavljenost s tisto pri kliničnih odmerkih, ni bilo opaziti neželenih učinkov povezanih z zdravljenjem.
English: You can use the handle of the second scoop to scrape off the extra powder and make your scoop level (see picture below).
Slovenian: Z držalom druge merice odstranite presežek praška s prve merice (glejte spodnjo sliko), tako da boste dobili izravnano površino na prvi merici.
English: Concomitant use of rifampicin is contraindicated with nelfinavir
Slovenian: Sočasna uporaba rifampicina in nelfinavirja je kontraindicirana.
English: Patients receiving VIRACEPT TID (n=11) achieved nelfinavir peak plasma concentrations (Cmax) of 3.0 ± 1.6 µg/ml and morning and evening trough concentrations of 1.4 ± 0.6 µg/ml and 1.0 ± 0.5 µg/ml, respectively.
Slovenian: Pri bolnikih (n = 11), ki so zdravilo VIRACEPT prejemali trikrat na dan, so bile največje koncentracije nelfinavirja v plazmi (Cmax) 3,0 ± 1,6 μg/ml, najnižje koncentracije pred naslednjim odmerkom zjutraj 1,4 ± 0,6 μg/ml in zvečer 1,0 ± 0,5 μg/ml.
English: Metabolic enzyme inducers: Potent inducers of CYP3A4 (e.g., rifampicin, pehnobarbital and carbamazepine) may reduce nelfianvir plasma concentrations and their coadministration is contraindicated (see section 4.3).
Slovenian: Induktorji presnovnih encimov: močni induktorji CYP3A4 (npr. rifampicin, fenobarbital in karbamazepin) lahko zmanjšajo plazemske koncentracije nelfinavirja in njihova sočasna uporaba je kontraindicirana (glejte poglavje 4.3).
English: If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before you take Viracept.
Slovenian: Če se karkoli od naštetega nanaša na vas ali, če ste negotovi, se pred jemanjem zdravila Viracept posvetujte z vašim zdravnikom ali s farmacevtom.
English: 7.5 to 8.5 kg
Slovenian: 7,5 do 8,5 kg
English: Dose to be administered three times a day to children aged 3 to 13 Recommended number of tablets at each meal
Slovenian: Odmerek dan trikrat na dan otrokom, starim od 3 do 13 let, s telesno maso Priporočeno število tablet danih ob vsakem
English: Nelfinavir AUC ↑ 30%
Slovenian: AUC nelfinavirja ↑ 30 %
English: At 24 weeks, the percentage of patients whose plasma HIV RNA levels had decreased to below the limit of detection of the assay (< 400 copies/ml) were 81 % and 8 % for the groups treated with nelfinavir 750 mg TID plus zidovudine and lamivudine or zidovudine and lamivudine, respectively.
Slovenian: Po 24 tednih je bil odstotek bolnikov, pri katerih se je HIV RNA v plazmi zmanjšala pod mejo zaznave metode (< 400 kopij/ml), 81 % za skupine, zdravljene s 750 mg nelfinavirja trikrat na dan v kombinaciji z zidovudinom in lamivudinom, ter 8 % za skupine, zdravljene le z zidovudinom in lamivudinom.
English: 10.5 to 12 kg*
Slovenian: 10,5 do 12 kg*
English: The efficacy of the BID (twice daily) regimen has been evaluated versus the TID (three times daily) regimen primarily in patients naïve to PIs (see section 5.1).
Slovenian: Učinkovitost odmerjanja dvakrat na dan v primerjavi z odmerjanjem trikrat na dan so proučevali v glavnem pri bolnikih, ki se še niso zdravili s PI (glejte poglavje 5.1).
English: The combination should be used with caution and a lower dose of trazodone should be considered.
Slovenian: Razmisliti je treba o manjšem odmerku trazodona.
English: Study APV30002 is a randomised, open-label trial of 649 antiretroviral treatment naïve patients with advanced HIV-disease, investigating fosamprenavir/ritonavir (1400 mg/200 mg QD n=322) compared to nelfinavir (1250 mg BID n=327), each in combination with lamivudine (150 mg twice daily) and abacavir (300 mg twice daily).
Slovenian: Študija APV3002 je randomizirana, preskušanje je odprto s 649 bolniki z napredovalo boleznijo HIV, ki še niso bili zdravljeni s protiretrovirusnimi učinkovinami, in preiskuje zdravljenje s fosamprenavirjem/ritonavirjem (1400 mg/200 mg enkrat na dan, n = 322) v primerjavi z nelfinavirjem (1250 mg dvakrat na dan, n = 327), vsakega v kombinaciji z lamivudinom (150 mg dvakrat na dan in abakavirjem (300 mg dvakrat na dan).
English: • Bosentan (for pulmonary arterial hypertension (PAH)
Slovenian: • bosentan (za zdravljenje pljučne arterijske hipertenzije (PAH)).
English: • Cisapride (for heart burn or problems with your digestive system)
Slovenian: • cisaprid (za zgago ali težave s prebavili),
English: Median baseline CD4+ cell counts were 177 and 166 x106 cells/l for the nelfinavir and fosamprenavir/ritonavir groups respectively.
Slovenian: Mediana začetne vrednosti števila celic CD4+ je bila 177 x 106 celic/l v skupini, zdravljeni z nelfinavirjem, in 166 x 106 celic/l v skupini, zdravljeni s fosamprenavirjem/ritonavirjem.
English: Patients with haemophilia: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthroses, in haemophiliac patients type A and B treated with PIs.
Slovenian: Bolniki s hemofilijo: pri bolnikih s hemofilijo tipa A in B, zdravljenih s PI, so se pojavile povečane krvavitve, vključno s spontanimi kožnimi hematomi, in krvavitvami v sklepe.
English: Methadone 80 mg + 21 mg qd > 1 month (Nelfinavir 1250mg bid x 8 days
Slovenian: Analgetiki metadon 80 mg + 21 mg enkrat na dan, > 1 mesec (nelfinavir 1250 mg dvakrat na dan, 8 dni
English: Metabolic enzyme inhibitors: Co-administration of nelfinavir with inhibitors of CYP2C19 (e.g., fluconazole, fluoxetine, paroxetine, lansoprazole, imipramine, amitriptyline and diazepam) may be expected to reduce the conversion of nelfinavir to its major active metabolite M8 (tert-butyl hydroxy nelfinavir) with a concomitant increase in plasma nelfinavir levels (see section 5.2).
Slovenian: Zaviralci presnovnih encimov: sočasno jemanje nelfinavirja z zaviralci CYP2C19 (npr. flukonazol, fluoksetin, paroksetin, lansoprazol, imipramin, amitriptilin in diazepam) lahko zmanjša pretvorbo nelfinavirja v njegov glavni aktivni presnovek M8 (terc-butil hidroksinelfinavir) in posledično poveča koncentracije nelfinavirja v plazmi (glejte poglavje 5.2).
English: Methadone AUC may be decreased when co-administered with nelfinavir; therefore upward adjustment of methadone dose may be required during concomitant use with nelfinavir.
Slovenian: AUC metadona se lahko zmanjša pri sočasni uporabi metadona z nelfinavirjem.
English: Interactions of nelfinavir with selected compounds that describe the impact of nelfinavir on the pharmacokinetics of the co-administered compound and the impact of other drugs on pharmacokinetics of nelfinavir are listed in Table 1.
Slovenian: V preglednici 1 so opisane interakcije nelfinavirja in izbranih zdravil, ki opisujejo vpliv nelfinavirja na farmakokinetiko sočasno danih zdravil in vpliv drugih zdravil na farmakokinetiko nelfinavirja.
English: • Lung disease (pneumonia).
Slovenian: • bolezni pljuč (pljučnica),
English: Common (affect less than 1 in 10 people):
Slovenian: Pogosti (pojavijo se pri manj kot 1 od 10 ljudi):
English: • Feeling sick.
Slovenian: • občutek slabosti,
English: Food taken with Viracept
Slovenian: Hrana zaužita z zdravilom Viracept
English: The recommended dose of VIRACEPT oral powder to be administered TID to children aged 3 to 13 years, using a combination of both the white 1 gram and the blue 5 gram scoop is shown in the following table.
Slovenian: Priporočeni odmerek peroralnega praška VIRACEPT za otroke, stare od 3 do 13 let, pri odmerjanju dvakrat na dan z uporabo kombinacije bele 1-g in modre 5-g merice je prikazan v spodnji preglednici.