FrancophonIA/ELRC3.0 huggingface dataset:
English: These tumours are unlikely to be of relevance to humans.
Croatian: Nije vjerojatno da su ti tumori relevantni za ljude.
English: If you take certain medicines your doctor may need to change the amount of doravirine you take.
Croatian: Ako uzimate određene lijekove, Vaš će liječnik možda morati promijeniti količinu doravirina koju uzimate.
English: Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: Difference (95 % CI)
Croatian: Razlika (95 % CI)
English: Delstrigo Once Daily ISG
Croatian: Delstrigo doziranje jedanput na dan ISG
English: Precautions to prevent transmission should be taken in accordance with national guidelines.
Croatian: Treba poduzeti mjere opreza za sprječavanje prijenosa u skladu s nacionalnim smjernicama.
English: The most frequently reported adverse reactions considered possibly or probably related to doravirine were nausea (4 %) and headache (3 %).
Croatian: Najčešće prijavljene nuspojave koje se smatralo moguće ili vjerojatno povezanima s primjenom doravirina bile su mučnina (4%) i glavobolja (3%).
English: If you accidentally take more, contact your doctor.
Croatian: Ako slučajno uzmete više, obratite se svom liječniku.
English: HIV is spread by contact with blood or through sexual contact with a person with HIV.
Croatian: HIV se prenosi kontaktom sa zaraženom krvlju ili spolnim kontaktom s osobom zaraženom HIV-om.
English: • Do not take two doses of Delstrigo at the same time to make up for a missed dose.
Croatian: • Nemojte uzeti dvije doze lijeka Delstrigo istovremeno kako biste nadoknadili propuštenu dozu.
English: ABC=abacavir; FTC=emtricitabine; DRV=darunavir; r=ritonavir
Croatian: ABC=abakavir; FTC=emtricitabin; DRV=darunavir; r=ritonavir
English: • increasing the number of white blood cells called ‘CD4
Croatian: • povećava broj bijelih krvnih stanica naziva „CD4
English: Worsening of hepatitis B infection
Croatian: Pogoršanje infekcije hepatitisa B
English: This can happen in some people who take Delstrigo.
Croatian: To se može dogoditi u nekih osoba koje uzimaju Delstrigo.
English: There are some medicines you must not take with Delstrigo.
Croatian: Postoje određeni lijekovi koje ne smijete uzimati s lijekom Delstrigo.
English: mannitol, lactitol or maltitol), if taken regularly
Croatian: manitol, laktitol ili maltitol, ako se uzimaju redovito.
English: Keep desiccant inside the bottle and do not throw away until you have finished taking all of the medicine.
Croatian: Ostavite sredstvo za sušenje u boci i nemojte ga baciti dok ne potrošite sav lijek.
English: ISG-DSG, Difference (95 % CI)*
Croatian: ISG-DSG, razlika (95 % CI)*
English: If you stop taking Delstrigo, your doctor will need to check your health often and do blood tests regularly for several months to check your HIV infection.
Croatian: Ako prestanete uzimati Delstrigo, liječnik će morati često provjeravati Vaše zdravstveno stanje i redovito provoditi krvne pretrage tijekom nekoliko mjeseci kako bi kontrolirao Vašu HIV infekciju.
English: Doravirine has a terminal half-life (t1/2) of approximately 15 hours.
Croatian: Doravirin ima terminalni poluvijek (t1/2) od približno 15 sati.
English: Do not give this medicine to anybody aged less than 18 years.
Croatian: Ovaj se lijek ne smije dati osobama mlađima od 18 godina.
English: There may be more than one in the bottle.
Croatian: U boci se može nalaziti više od jednog pakiranja sredstva za sušenje.
English: If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, talk to your doctor about the risks and benefits of taking Delstrigo.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, razgovarajte sa svojim liječnikom o rizicima i koristima uzimanja lijeka Delstrigo.
English: • abnormal dreams, difficulty in sleeping (insomnia)
Croatian: • neuobičajeni snovi, poteškoće sa spavanjem (nesanica)
English: There is no evidence that elderly patients require a different dose than younger adult patients (see section 5.2).
Croatian: Nema dokaza da je starijim bolesnicima potrebna drugačija doza nego mlađim odraslim bolesnicima (vidjeti dio 5.2).
English: AUC0-24 μM hr
Croatian: AUC0-24 μM h
English: glecaprevir, pibrentasvir
Croatian: glekaprevir, pibrentasvir
English: Other medicines and Delstrigo
Croatian: Drugi lijekovi i Delstrigo
English: Do not take Delstrigo if the above applies to you.
Croatian: Nemojte uzimati Delstrigo ako se nešto od navedenog odnosi na Vas.
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), or very rare (< 1/10,000).
Croatian: Učestalost je definirana kao vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000) ili vrlo rijetko (< 10 000).
English: Discontinued study for Other Reasons
Croatian: Prekid ispitivanja zbog drugih uzroka
English: There is insufficient information on the effects of tenofovir in newborns/infants.
Croatian: Nema dovoljno informacija o učincima tenofovira u novorođenčadi/dojenčadi.
English: Other reasons include: lost to follow-up, non-compliance with study drug, physician decision, protocol deviation, withdrawal by subject.
Croatian: Drugi uzroci uključuju: gubitak praćenja, neusklađenost s lijekom u ispitivanju, odluku liječnika, odstupanje od protokola, povlačenje ispitanika.
English: • Swallow the tablet whole (do not crush or chew).
Croatian: • Tableta se mora progutati cijela (ne smije se drobiti niti žvakati).
English: Always take this medicine exactly as your doctor, pharmacist, or nurse has told you.
Croatian: Uvijek uzmite ovaj lijek točno onako kako Vam je rekao liječnik, ljekarnik ili medicinska sestra.
English: Week 96*
Croatian: 96. tjedan*
English: *For Week 96, certain subjects with missing HIV-1 RNA were excluded from the analysis.
Croatian: *Za 96. tjedan, određeni ispitanici kojima je nedostajao HIV-1 RNK bili su isključeni iz analize.
English: Women with HIV should not breastfeed because HIV can be passed on to babies through breast milk.
Croatian: Žene s HIV infekcijom ne bi smjele dojiti jer mogu mlijekom prenijeti HIV na dijete.
English: In humans, the only known metabolite is the trans-sulphoxide metabolite (approximately 5 % of an oral dose after 12 hours).
Croatian: Jedini poznati metabolit u ljudi je trans-sulfoksidni metabolit (približno 5% peroralne doze nakon 12 sati).
English: Some patients required hospitalisation and renal replacement therapy.
Croatian: Nekim je bolesnicima bila potrebna hospitalizacija i bubrežna nadomjesna terapija.
English: What Delstrigo is and what it is used for What you need to know before you take Delstrigo How to take Delstrigo
Croatian: Što je Delstrigo i za što se koristi Što morate znati prije nego počnete uzimati Delstrigo Kako uzimati Delstrigo
English: These differences in pharmacokinetics are not clinically relevant.
Croatian: Te razlike u farmakokinetici nisu klinički značajne.
English: No Virologic Data Within the Time Window
Croatian: Bez viroloških podataka u okviru vremena ispitivanja
English: Table 1: Interactions between the individual components of Delstrigo and other medicinal products
Croatian: Tablica 1: Interakcije između pojedinačnih sastavnica lijeka Delstrigo i drugih lijekova
English: While effective viral suppression with antiretroviral therapy has been proven to substantially reduce the risk of sexual transmission of HIV-1, a residual risk cannot be excluded.
Croatian: Iako je dokazano da učinkovita virusna supresija antiretrovirusnom terapijom značajno smanjuje rizik od prijenosa HIV-1 spolnim putem, ne može se isključiti rezidualni rizik.
English: Physicians are encouraged to register patients in this registry.
Croatian: Pozivaju se liječnici da takve bolesnice prijave u registar.
English: Biliary excretion of unchanged medicinal product may contribute to the elimination of doravirine, but this elimination route is not expected to be significant.
Croatian: Izlučivanje lijeka kroz žuč u nepromijenjenu obliku može pridonijeti eliminaciji doravirina, no ne očekuje se da će taj put eliminacije biti značajan.
English: This is because it has not been studied in pregnancy and it is not known if Delstrigo will harm your baby while you are pregnant.
Croatian: Naime, nije se ispitivala njegova primjena tijekom trudnoće i nije poznato hoće li Delstrigo naškoditi Vašem djetetu dok ste trudni.
English: • Do not use this medicine after the expiry date which is stated on the bottle after EXP.
Croatian: • Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na boci i kutiji iza oznake „EXP“.
English: Delstrigo contains the active substances:
Croatian: Delstrigo sadrži sljedeće djelatne tvari:
English: Talk to your doctor before taking the following medicines with Delstrigo as your doctor may need to change the dose of your medicines:
Croatian: Razgovarajte sa svojim liječnikom prije nego što počnete uzimati sljedeće lijekove dok uzimate lijek Delstrigo, jer će liječnik možda morati promijeniti dozu Vaših lijekova:
English: Psychostimulants modafinil
Croatian: Psihostimulansi modafinil
English: • rifampicin, rifapentine
Croatian: • rifampicin, rifapentin
English: • It is important that you do not miss or skip doses of Delstrigo.
Croatian: • Važno je da ne propuštate ili preskačete doze lijeka Delstrigo.
English: Carcinogenesis
Croatian: Kancerogeneza
English: This should be considered when assessing a patient's ability to drive or operate machinery.
Croatian: O tome treba voditi računa kada se ocjenjuje bolesnikova sposobnost upravljanja vozilima ili rada sa strojevima.
English: Delstrigo is a complete regimen for the treatment of HIV-1 infection; therefore, Delstrigo should not be administered with other antiretroviral medicinal products.
Croatian: Delstrigo je cjelovit režim za liječenje HIV-1 infekcije; stoga se Delstrigo ne smije primjenjivati s drugim antiretrovirusnim lijekovima.
English: Use with caution when driving, riding a bicycle, or operating machines if you feel tired, dizzy, or sleepy after taking this medicine
Croatian: Budite oprezni dok upravljate vozilom, vozite bicikl ili radite sa strojevima ako osjećate umor, omaglicu ili pospanost nakon uzimanja ovog lijeka.
English: Delstrigo may have a minor influence on the ability to drive and use machines.
Croatian: Delstrigo može malo utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Safety and efficacy of Delstrigo have not been established in patients younger than 18 years of age.
Croatian: Sigurnost i djelotvornost lijeka Delstrigo nisu ustanovljene u bolesnika mlađih od 18 godina.
English: You should not take Delstrigo if your doctor has told you that the virus causing your infection is resistant to any of the medicines in Delstrigo.
Croatian: Ne smijete uzimati Delstrigo ako Vam je liječnik rekao da je virus koji kod Vas uzrokuje infekciju otporan na bilo koji od pojedinačnih lijekova sadržanih u lijeku Delstrigo.
English: Metabolism of lamivudine is a minor route of elimination.
Croatian: Metabolizam lamivudina sporedni je put eliminacije.
English: • medicines (usually liquids) containing sorbitol and other sugar alcohols (such as xylitol,
Croatian: • lijekove (obično tekućine) koji sadrže sorbitol i druge šećerne alkohole (kao što su ksilitol,
English: Doravirine is primarily metabolised and eliminated by the liver.
Croatian: Doravirin se primarno metabolizira i eliminira putem jetre.
English: HIV is the virus that causes AIDS (‘acquired immune deficiency syndrome').
Croatian: HIV je virus koji uzrokuje AIDS (sindrom stečene imunodeficijencije).
English: EU/1/18/1333/001 EU/1/18/1333/002 90 (3 x 30) tablets
Croatian: EU/1/18/1333/001 EU/1/18/1333/002 90 (3 x 30) tableta
English: Tell your doctor right away if you start having any new symptoms after starting your HIV medicine.
Croatian: Odmah obavijestite svog liječnika ako se pojavi bilo koji novi simptom nakon što počnete uzimati lijek za liječenje infekcije HIV-om.
English: Lamivudine Lamivudine does not inhibit or induce CYP enzymes.
Croatian: Lamivudin Lamivudin ne inhibira niti inducira CYP enzime.
English: Doravirine 100 mg once daily
Croatian: Doravirin 100 mg jedanput na dan
English: If bone abnormalities are suspected, then appropriate consultation should be obtained.
Croatian: U slučaju sumnje na abnormalnosti kostiju, treba se konzultirati s odgovarajućim specijalistom.
English: Lamivudine is a nucleoside analogue.
Croatian: Lamivudin je nukleozidni analog.
English: Information regarding potential medicinal product interactions with other antiretroviral medicines is not provided.
Croatian: Ne navode se informacije o mogućim interakcijama ovog lijeka s drugim antiretrovirusnim lijekovima.
English: Delstrigo is used to treat HIV infection in people 18 years of age and older.
Croatian: Delstrigo se koristi za liječenje HIV infekcije u osoba u dobi od 18 i više godina.
English: Blood tests may also show: • increased levels in liver enzymes (ALT)
Croatian: Krvne pretrage mogu pokazati i: • povišene vrijednosti enzima jetre (ALT)
English: Your doctor will do blood tests to check your kidney function before and during treatment with Delstrigo.
Croatian: Vaš će liječnik provoditi krvne pretrage kako bi provjerio rad Vaših bubrega prije i tijekom liječenja lijekom Delstrigo.
English: • increased levels in liver enzymes (AST)
Croatian: • povišene vrijednosti enzima jetre (AST)
English: Following oral administration, lamivudine is rapidly absorbed and extensively distributed.
Croatian: Lamivudin se nakon peroralne primjene brzo apsorbira i opsežno distribuira.
English: Steady state was generally achieved by Day 2 of once daily dosing, with accumulation ratios of 1.2 to 1.4 for AUC0-24, Cmax, and C24.
Croatian: Stanje dinamičke ravnoteže obično se postiglo do 2. dana primjene jedanput na dan, uz omjere kumulacije od 1,2 do 1,4 za AUC0-24, Cmax i C24.
English: Safety and efficacy of lamivudine have not been established in the presence of decompensated liver disease.
Croatian: Nisu ustanovljene sigurnost i djelotvornost lamivudina u prisutnosti dekompenzirane bolesti jetre.
English: Autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Croatian: Autoimuni poremećaji (stanje koje se javlja kada imunološki sustav napada zdravo tkivo u tijelu) mogu se javiti nakon što počnete uzimati lijekove za liječenje infekcije HIV-om.
English: ombitasvir/paritaprevir/ ritonavir and dasabuvir +/ritonavir
Croatian: ombitasvir/ paritaprevir/ritonavir i dasabuvir +/- ritonavir
English: Very rare pure red cell aplasia*
Croatian: vrlo rijetko aplazija crvenih krvnih stanica*
English:  = increase, ↓ = decrease, ↔ = no change CI = Confidence Interval; SD = Single Dose; QD = Once Daily; BID = Twice Daily *AUC0- for single dose, AUC0-24 for once daily.
Croatian: Confidence Interval) = interval pouzdanosti; SD = jednokratna doza; QD = doziranje jedanput na dan; BID = doziranje dvaput na dan *AUC0- za jednokratnu dozu, AUC0-24 za primjenu jedanput na dan.
English: These medicinal products include, but are not limited to the following:
Croatian: Ti lijekovi uključuju, između ostalih:
English: You can still pass on HIV when taking Delstrigo, although effective therapy lowers the risk.
Croatian: HIV možete prenijeti čak i dok uzimate Delstrigo, premda je tada rizik manji zbog učinkovite terapije.
English: Week 24 N=223
Croatian: 24. tjedan N=223
English: Cross-resistance has been observed among NRTIs.
Croatian: Među NRTI-jima je opažena križna rezistencija.
English: Rare dyspnoea, tonsillar hypertrophy
Croatian: rijetko dispneja, hipertrofija tonzila
English: If you have HIV infection and hepatitis B infection, it is especially important not to stop your Delstrigo treatment without talking to your doctor first.
Croatian: Ako ste uz HIV zaraženi i virusom hepatitisa B, osobito je važno da ne prestanete uzimati Delstrigo bez prethodnog razgovora sa svojim liječnikom.
English: In vitro studies have determined that neither tenofovir disoproxil nor tenofovir are substrates for the CYP450 enzymes.
Croatian: U ispitivanjima in vitro utvrđeno je da ni tenofovirdizoproksil ni tenofovir nisu supstrati za enzime CYP450.
English: Less than 0.7 % of tenofovir binds to human plasma proteins in vitro over the range of 0.01 to 25 micrograms per mL.
Croatian: Manje od 0,7% tenofovira vezuje se za proteine u plazmi ljudi in vitro u rasponu od 0,01 do 25 μg/ml.
English: NRTI backbone M184I/V only K65R only K65R + M184I/V
Croatian: NRTI osnovica samo M184I/V samo K65R K65R + M184I/V
English: What you need to know before you take Delstrigo
Croatian: Što morate znati prije nego počnete uzimati Delstrigo
English: Lamivudine may inhibit cellular DNA replication (see section 5.3).
Croatian: Lamivudin može inhibirati replikaciju stanične DNK (vidjeti dio 5.3).
English: The clinical relevance of a 5-10 fold change reduction in susceptibility is unknown.
Croatian: Klinički značaj smanjenja osjetljivosti za 5 - 10 puta nije poznat.
English: See also the list in section “Other Medicines and Delstrigo”.
Croatian: Pogledajte i popis u odlomku „Drugi lijekovi i Delstrigo“.
English: This is because other medicines may affect how Delstrigo works, and Delstrigo might affect the way some other medicines work.
Croatian: Naime, drugi lijekovi mogu utjecati na djelovanje lijeka Delstrigo, baš kao što i Delstrigo može utjecati na djelovanje nekih drugih lijekova.
English: Endothelin Receptor Antagonists bosentan
Croatian: Antagonisti endotelinskih receptora bosentan
English: Table 1 shows the established and other potential medicinal product interactions with the individual components of Delstrigo but is not all inclusive (increase is indicated as ↑, decrease is indicated as , and no change as ).
Croatian: Tablici 1 navode se utvrđene i druge potencijalne interakcije između pojedinačnih sastavnica lijeka Delstrigo i drugih lijekova, ali ona ne uključuje sve moguće interakcije (povećanje je označeno kao ↑, smanjenje kao ↓, a stanje bez promjene kao ↔).
English: No human data on the effect of Delstrigo on fertility are available.
Croatian: Nema dostupnih podataka o učinku lijeka Delstrigo na plodnost ljudi.
English: Doravirine exhibited an EC50 value of 12.0±4.4 nM against wild-type laboratory strains of HIV-1 when tested in the presence of 100 % normal human serum using MT4-GFP reporter cells.
Croatian: Doravirin je iskazao vrijednost EC50 od 12,0 ± 4,4 nM protiv laboratorijskih sojeva HIV-1 divljeg tipa kada se ispitivao u prisutnosti 100%-tnog normalnog humanog seruma primjenom reporterskih stanica MT4-GFP.
English: CD4 count, cells/µL
Croatian: Broj CD4 stanica, stanica/µl
English: Patients who are co-infected with HIV-1 and HBV should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment with Delstrigo.
Croatian: Bolesnike s istodobnom infekcijom virusom HIV-1 i HBV-om treba pažljivo nadzirati kliničkim i laboratorijskim praćenjem tijekom najmanje nekoliko mjeseci nakon prekida liječenja lijekom Delstrigo.
English: Calcium Channel Blockers diltiazem verapamil
Croatian: Blokatori kalcijevih kanala diltiazem verapamil
English: Studies with lamivudine show that plasma concentrations (AUC) are increased in patients with renal dysfunction due to decreased clearance.
Croatian: Ispitivanja lamivudina pokazuju da su koncentracije u plazmi (AUC) povišene u bolesnika s poremećajem rada bubrega, zbog smanjenog klirensa.
English: Viral subtype non-B
Croatian: Podtip virusa ne-B
English: In some patients with advanced liver disease or cirrhosis, stopping treatment is not recommended as this may lead to worsening of your hepatitis, which may be life-threatening.
Croatian: U nekih bolesnika s uznapredovalom bolešću jetre ili cirozom ne preporučuje se prekinuti liječenje jer to može dovesti do pogoršanja hepatitisa, što može biti opasno po život.
English: Infections and infestations Rare rash pustular
Croatian: Infekcije i infestacije rijetko pustularni osip
English: Based on more than 200 mother/child pairs treated for HIV, serum concentrations of lamivudine in breast-fed infants of mothers treated for HIV are very low (< 4 % of maternal serum concentrations) and progressively decrease to undetectable levels when breast-fed infants reach 24 weeks of age.
Croatian: Na temelju više od 200 parova majka/dijete liječenih zbog HIV infekcije utvrđeno je da su koncentracije lamivudina u serumu dojenčadi čije su majke liječene zbog HIV infekcije vrlo niske (< 4% koncentracija u serumu majke) i progresivno se smanjuju do nemjerljivih razina kada dojenče navrši 24 tjedna.
English: NNRTI-associated mutations detected at screening were part of exclusion criteria in the Phase 2b/3-studies.
Croatian: Mutacije povezane s rezistencijom na NNRTI-je utvrđene pri probiru bile su dio isključnih kriterija u ispitivanjima faze IIb/III.
English: It is not known whether the exposure to doravirine will increase in patients with severe hepatic impairment.
Croatian: Nije poznato hoće li se izloženost doravirinu povećati u bolesnika s teškim oštećenjem funkcije jetre.
English: During the initial phase of combination antiretroviral treatment, patients whose immune system responds may develop an inflammatory response to indolent or residual opportunistic infections (such as Mycobacterium avium infection, cytomegalovirus, Pneumocystis jirovecii pneumonia [PCP], or tuberculosis), which may necessitate further evaluation and treatment.
Croatian: Tijekom početne faze kombiniranog antiretrovirusnog liječenja, u bolesnika čiji imunološki sustav odgovori na liječenje može se razviti upalni odgovor na indolentne ili rezidualne oportunističke infekcije (kao što su infekcija izazvana Mycobacterium avium, citomegalovirus, pneumonija izazvana Pneumocystis jirovecii [PCP] ili tuberkuloza), što može zahtijevati daljnju ocjenu i liječenje.
English: What Delstrigo is and what it is used for
Croatian: Što je Delstrigo i za što se koristi
English: Baseline Regimen DSG
Croatian: Početni režim DSG
English: There were insufficient numbers from racial and ethnic groups other than Caucasian to adequately determine potential pharmacokinetic differences among these populations following the administration of tenofovir disoproxil.
Croatian: Nije bilo dovoljno pripadnika drugih rasnih i etničkih skupina osim bijelaca da bi se adekvatno odredile moguće farmakokinetičke razlike između tih populacija nakon primjene tenofovirdizoproksila.
English: Pharmacotherapeutic group: Antivirals for systemic use, ATC code: J05AR24
Croatian: Farmakoterapijska skupina: Lijekovi za liječenje sustavnih virusnih infekcija, ATK oznaka: J05AR24
English: Ribavirin (50 microM) used in the treatment of chronic HCV infection decreased the anti-HIV-1 activity of lamivudine by 3.5-fold in MT-4 cells.
Croatian: Ribavirin (50 µM) primijenjen za liječenje kronične HCV infekcije smanjio je aktivnosti lamivudina protiv HIV-1 za 3,5 puta u MT-4 stanicama.
English: Miscellaneous sorbitol solution (3.2 g, 10.2 g, 13.4 g)/lamivudine
Croatian: Razno otopina sorbitola (3,2 g; 10,2 g; 13,4 g)/lamivudin
English: Bone loss and mineralisation defects
Croatian: Gubitak kosti i poremećaji mineralizacije
English: There are no data available on the safety of lamivudine when administered to babies less than three months old.
Croatian: Nisu dostupni podaci o sigurnosti lamivudina kod primjene u djece mlađe od tri mjeseca.
English: Week 48 N=447
Croatian: 48. tjedan N=447
English: Doravirine at a dose of 100 mg once daily is not likely to have a clinically relevant effect on the plasma concentrations of medicinal products that are dependent on transport proteins for absorption and/or elimination or that are metabolised by CYP enzymes.
Croatian: Nije vjerojatno da će doza doravirina od 100 mg jedanput na dan klinički značajno utjecati na koncentracije lijekova u plazmi čija apsorpcija i/ili eliminacija ovise o transportnim proteinima ili koji se metaboliziraju putem CYP enzima.