FrancophonIA/ELRC3.0 huggingface dataset:
English: The elimination half-life (t½) of lesinurad was approximately 5 hours following a single dose.
Slovenian: Razpolovni čas izločanja (t½) lesinurada po enkratnem odmerku je bil približno 5 ur.
English: In interaction studies conducted in healthy subjects with lesinurad and CYP3A substrates, lesinurad reduced the plasma concentrations of sildenafil and amlodipine.
Slovenian: V študijah medsebojnih delovanj lesinurada in substratov CYP3A na zdravih osebah je lesinurad zmanjšal koncentracijo sildenafila in amlodipina v plazmi.
English: Vidarabine (Adenine Arabinoside)
Slovenian: Vidarabin (adenin arabinozid)
English: Mild to moderate induction of CYP3A by concomitantly administered lesinurad may reduce or eventually reverse this effect.
Slovenian: Blaga do zmerna indukcija CYP3A, ki jo povzroči sočasno jemanje lesinurada, lahko zmanjša ali sčasoma odpravi ta učinek.
English: This is approximately the concentration which would be achieved by doses of 600 mg/day in those with normal renal function.
Slovenian: Ta vrednost približno ustreza koncentraciji, ki bi bila dosežena pri odmerku 600 mg na dan pri bolnikih z normalnim delovanjem ledvic.
English: Concurrent use of allopurinol and ACE inhibitors may lead to an increased risk of hypersensitivity, especially if there is pre-existing renal impairment.
Slovenian: Sočasna uporaba alopurinola in zaviralcev ACE lahko privede do povečanega tveganja za preobčutljivost, predvsem ob predhodni okvari ledvic.
English: Your doctor may tell you to restart treatment with Duzallo when your kidneys improve.
Slovenian: Zdravnik vam lahko naroči, da ponovno pričnete jemati zdravilo Duzallo, ko se vam delovanje ledvic izboljša.
English: Data from long-term extension studies until 52 months revealed a renal safety profile consistent with that observed in the placebo-controlled studies.
Slovenian: Ledvični varnostni profil na podlagi podatkov dolgoročnih podaljšanih študij do 52 mesecev se sklada z varnostnim profilom, ugotovljenim v študijah, nadzorovanih s placebom.
English: In healthy volunteers and HIV patients receiving didanosine, plasma didanosine maximum plasma concentration (Cmax ) and area under the curve (AUC) values were approximately doubled with concomitant allopurinol treatment (300 mg daily) without affecting terminal half-life.
Slovenian: Pri zdravih prostovoljcih in bolnikih z okužbo HIV, ki so prejemali didanozin, sta bili vrednosti najvišje plazemske koncentracije (Cmax) in področja pod krivulja (AUC) približno podvojeni ob sočasnem zdravljenju z alopurinolom (300 mg na dnevno), ne da bi to vplivalo na končni razpolovni čas.
English: Caution is required when allopurinol is used in patients with alteration of thyroid function.
Slovenian: Previdnost je potrebna pri uporabi alopurinola pri bolnikih s spremenjenim delovanjem ščitnice.
English: In clinical trials, most adverse reactions were mild or moderate in intensity and resolved while continuing lesinurad therapy.
Slovenian: V kliničnih preskušanjih je bila večina neželenih učinkov blagih ali zmernih in so med nadaljevanjem zdravljenja z lesinuradom izzveneli.
English: What you need to know before you take Duzallo
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Duzallo
English: In the long-term uncontrolled extension trials, the rates of gout flares requiring treatment further decreased in the 60% of subjects who entered the extension studies and continued treatment with lesinurad 200 mg in combination with allopurinol or febuxostat for up to an additional year of treatment.
Slovenian: V dolgoročnih nekontroliranih podaljšanjih preskušanj so se deleži napadov protina, ki so zahtevali zdravljenje, dodatno zmanjšali pri 60% bolnikov, ki so vstopili v podaljšane študije in nadaljevali zdravljenje z 200 mg lesinurada v kombinaciji z alopurinolom ali febuksostatom v obdobju do enega dodatnega leta zdravljenja.
English: If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking Duzallo.
Slovenian: Če kaj od naštetega velja za vas (ali če niste prepričani), se pred jemanjem zdravila Duzallo posvetujte z zdravnikom ali farmacevtom.
English: Chlorpropamide
Slovenian: Klorpropamid
English: There should be an interval of at least 3 hours between the concomitant use of those medicinal products.
Slovenian: Pri sočasni uporabi teh zdravil, moramo pri njunem jemanju upoštevati vsaj 3-urni interval med zdraviloma.
English: In animal studies, long-term use of high allopurinol doses resulted in formation of xanthine precipitates, which led to changes in the urinary tract.
Slovenian: V študijah na živalih je dolgotrajna uporaba visokih odmerkov alopurinola povzročila nastanek oborin ksantina, kar je vodilo k spremembam na sečilih.
English: Therefore, it is recommended that Duzallo should be used with caution in patients taking moderate inhibitors of CYP2C9.
Slovenian: Zato je priporočljivo zdravilo Duzallo previdno uporabljati pri bolnikih, ki jemljejo zmerne zaviralce CYP2C9.
English: Serum concentrations of 6-mercaptopurine and azathioprine can reach toxic levels unless dose reduction is undertaken.
Slovenian: Koncentracije 6-merkaptopurina in azatioprina lahko dosežejo toksične vrednosti, če ne znižamo odmerka.
English: The recommended dose is one tablet of Duzallo (200 mg/200 mg or 300 mg/200 mg) once daily.
Slovenian: Priporočeni odmerek je ena tableta zdravila Duzallo (200 mg/200 mg ali 300 mg/200 mg) enkrat dnevno.
English: Allopurinol has a plasma half-life of about 0.5 to 1.5 hours.
Slovenian: Razpolovni čas alopurinola je približno 0,5 do 2 uri.
English: Allopurinol and its metabolite oxypurinol are excreted in human breast milk.
Slovenian: Alopurinol in njegov presnovek oksipurinol se izločata v materino mleko.
English: In the same trials, all patients with a MACE treated with lesinurad 200 mg had a history of heart failure, stroke or myocardial infarction.
Slovenian: V istih preskušanjih so vsi bolniki z MACE, ki so bili zdravljeni z 200 mg lesinurada, imeli v anamnezi srčno popuščanje, možgansko kap ali miokardni infarkt.
English: If aluminium hydroxide is taken concomitantly, allopurinol-containing medicinal products may have an attenuated effect.
Slovenian: Pri sočasni uporabi aluminijevega hidroksida imajo lahko zdravila, ki vsebujejo alopurinol, oslabljen učinek.
English: Patients taking Duzallo which contains the active substance allopurinol and 6mercaptopurine or azathioprine must reduce their dose to 25 % of the intended dose of 6
Slovenian: Bolniki, ki jemljejo zdravilo Duzallo, ki vsebuje učinkovino alopurinol, in 6-merkaptopurin ali azatioprin, morajo odmerek 6-merkaptopurina ali azatioprina zmanjšati na 25% njim prvotno namenjenega odmerka.
English: Based on its mechanism of action, lesinurad may not be effective in these patients (see section
Slovenian: Glede na njegov način delovanja, lesinurad pri teh bolnikih morda ni učinkovit (glejte poglavje 5.1).
English: Hypersensitivity syndrome, Stevens-Johnson-Syndrome (SJS ) and toxic epidermal necrolysis (TEN)
Slovenian: Sindrom preobčutljivosti, Stevens-Johnsonov sindrom (SJS) in toksična epidermalna nekroliza (TEN)
English: Duzallo and all additional doses of allopurinol should be discontinued immediately at the first appearance of allopurinol-induced skin rash or other signs which may indicate an allergic reaction and additional medical care should be provided as needed.
Slovenian: Zdravljenje z zdravilom Duzallo in vsemi dodatnimi odmerki alopurinola moramo ob prvem pojavu kožnega izpuščaja, povezanega z alopurinolom, ali drugih znakih alergijske reakcije, nemudoma prekiniti in po potrebi uvesti dodatno zdravljenje.
English: Duzallo has not been studied in patients with severe hepatic impairment; therefore, no dose recommendations can be given for Duzallo.
Slovenian: Študij na bolnikih s hudo okvaro jeter z zdravilom Duzallo niso izvedli, zato priporočil za odmerjanje zdravila Duzallo ni mogoče dati.
English: Hydroxypropylcellulose Microcrystalline cellulose Lactose monohydrate Crospovidone Magnesium stearate
Slovenian: Jedro tablete hidroksipropilceluloza mikrokristalna celuloza laktoza monohidrat krospovidon magnezijev stearat
English: Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, medicinal product eruption, alopecia, hair colour changes
Slovenian: Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, angioedem, medikamentozni izpuščaj, alopecija, spremenjena barva las
English: Duzallo may cause serious kidney problems (see section 4).
Slovenian: Zdravilo Duzallo lahko povzroči resne težave z ledvicami (glejte poglavje 4).
English: Patients continued their allopurinol dose and were randomised 1:1:1 to receive lesinurad 200 mg, lesinurad 400 mg, or placebo once daily.
Slovenian: Bolniki so še naprej uporabljali svoj odmerek alopurinola in so bili v razmerju 1:1:1 randomizirani na prejemanje 200 mg lesinurada, 400 mg lesinurada ali placeba enkrat na dan.
English: In clinical trials, lesinurad was administered with food, because the serum uric acid lowering was improved under fed conditions (see section 4.2).
Slovenian: V kliničnih preskušanjih so lesinurad uporabljali s hrano, ker je bilo znižanje sečne kisline v serumu na poln želodec boljše (glejte poglavje 4.2).
English: 6-mercaptopurine and azathioprine
Slovenian: 6-merkaptopurin in azatioprin
English: Salicylates and non-selective uricosuric active substances such as probenecid Salicylates at doses higher than 325 mg per day may decrease the serum uric acid lowering activity of lesinurad and should not be co-administered with Duzallo.
Slovenian: Salicilati in neselektivne urikozurične učinkovine, kot je npr. probenecid Salicilati lahko v odmerkih nad 325 mg na dan oslabijo vpliv lesinurada na znižanje sečne kisline v serumu in se jih ne sme uporabljati skupaj z zdravilom Duzallo.
English: Hence, medicinal products with known non-selective uricosuric activity such as probenecid or large doses of salicylates may accelerate the excretion of oxypurinol.
Slovenian: Zdravila, ki imajo neselektiven urikozurični učinek, kot ga imata probenecid ali visoki odmerki salicilatov, lahko pospešijo izločanje oksipurinola.
English: Allopurinol is rapidly absorbed from the gastrointestinal tract and is reported to have a plasma half-life of about one hour.
Slovenian: Alopurinol Alopurinol se hitro absorbira iz prebavil in ima razpolovni čas v plazmi približno 1 uro.
English: If you forget to take Duzallo
Slovenian: Če ste pozabili vzeti zdravilo Duzallo
English: Female patients of childbearing age should practice additional methods of contraception and not rely on hormonal contraception alone when taking Duzallo (see sections 4.5 and 4.6).
Slovenian: Ženske v rodni dobi morajo uporabljati dodatne načine kontracepcije in se med jemanjem zdravila Duzallo ne smejo zanašati le na hormonsko kontracepcijo (glejte poglavji 4.5 in 4.6).
English: Epoxide hydrolase inhibitors (e.g. valproic acid, valpromide) Inhibitors of microsomal Epoxide Hydrolase (mEH) (e.g. valproic acid, valpromide) may interfere with the metabolism of lesinurad.
Slovenian: Zaviralci epoksid-hidrolaze (npr. valprojska kislina, valpromid) Zaviralci mikrosomalne epoksid-hidrolaze (mEH - microsomal Epoxide Hydrolase) (npr. valprojska kislina, valpromid) lahko ovirajo presnovo lesinurada.
English: Reproductive studies with allopurinol have been performed in rats and rabbits at doses up to twenty times the usual human dose and it was concluded that there was no impaired fertility.
Slovenian: Študije vpliva na razmnoževanje z alopurinolom na podganah in kuncih v odmerkih, ki so do dvajsetkrat višji od običajnih odmerkov pri ljudeh, niso pokazali zmanjšanja plodnosti.
English: An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both medicinal products.
Slovenian: Povečanje pogostnosti kožnega izpuščaja so opazili pri bolnikih, ki so prejemali ampicilin ali amoksicilin sočasno z alopurinolom, v primerjavi z bolniki, ki niso prejemali obeh zdravil sočasno.
English: Treatment with lesinurad 200 mg in combination with allopurinol was associated with an increased incidence of serum creatinine elevations, which are related to increased renal uric acid excretion.
Slovenian: Zdravljenje z lesinuradom 200 mg v kombinaciji z alopurinolom je spremljala večja pogostnost zvišanj kreatinina v serumu; ta so povezana z večjim izločanjem sečne kisline v ledvicah.
English: One study in mice receiving intraperitoneal doses of 50 or 100 mg/kg on days 10 or 13 of gestation resulted in foetal abnormalities, however in a similar study in rats at 120 mg/kg on day 12 of gestation no abnormalities were observed.
Slovenian: V študiji na miših, ki so prejemale alopurinol intraperitonealno v odmerkih 50 ali 100 mg/kg na 10. ali 13. dan brejosti, je prišlo do pojava fetalnih nenormalnosti, vendar v podobni študiji na podganah pri odmerku 120 mg/kg na 12. dan brejosti niso opazili nenormalnosti.
English: Mean plasma-to-blood ratios of lesinurad AUC and Cmax were approximately 1.8, indicating that it did not penetrate or partition extensively into red blood cells.
Slovenian: Povprečno razmerje AUC in Cmax lesinurada v plazmi in krvi je bilo približno 1,8; to kaže, da ni v veliki meri prodiral ali se porazdelil v eritrocite.
English: If you stop taking Duzallo
Slovenian: Če ste prenehali jemati zdravilo Duzallo
English: Oxypurinol is eliminated unchanged in the urine but has a long elimination half-life because it undergoes tubular reabsorption.
Slovenian: Oksipurinol se v seču izloča nespremenjen, vendar ima zaradi tubularne reabsorpcije daljši razpolovni čas izločanja.
English: Warnings and precautions Talk to your doctor or pharmacist before taking Duzallo if:
Slovenian: Opozorila in previdnostni ukrepi Pred začetkom jemanja zdravila Duzallo se posvetujte z zdravnikom ali farmacevtom:
English: If the patient is a known carrier of HLA-B*5801, especially in those who are of Han Chinese, Thai or Korean descent, allopurinol should not be started unless there are no other reasonable therapeutic options and the benefits are thought to exceed risks.
Slovenian: Če je znano, da je bolnik nosilec HLA-B*5801 alela, zlasti če je potomec Han Kitajcev, Tajcev ali Korejcev, se zdravljenje z alopurinolom ne bi smelo pričeti, razen v primerih, kadar ni drugih možnosti zdravljenja in so koristi večje od tveganja.
English: If Duzallo which contains the active substance allopurinol is given concomitantly with chlorpropamide when renal function is poor, there may be an increased risk of prolonged hypoglycaemic activity.
Slovenian: Če uporabljamo zdravilo Duzallo, ki vsebuje učinkovino alopurinol, sočasno s klorpropamidom, lahko ob slabem delovanju ledvic pride do tveganja za podaljšan hipoglikemični učinek.
English: Patients known to be CYP2C9 poor metabolisers should be treated with caution, as the potential risk of lesinurad renal-related adverse reactions may be increased (see sections 4.8 and 5.2).
Slovenian: Bolnike, ki so slabi presnavljalci s CYP2C9, je treba zdraviti previdno, ker imajo lahko večje tveganje za neželene učinke na ledvicah, povezane z lesinuradom (glejte poglavji 4.8 in 5.2).
English: The kinetics of allopurinol are not likely to be altered other than due to deterioration in renal function (see section 5.2 renal impairment).
Slovenian: Ni verjetno, da bi bila kinetika alopurinola spremenjena, razen zaradi zmanjšanega delovanja ledvic (glejte poglavje 5.2 Okvara ledvic).
English: It is used to treat gout in adult patients in case allopurinol alone is not controlling your gout.
Slovenian: Uporablja se ga za zdravljenje protina pri odraslih bolnikih, če z alopurinolom samim ne nadzorujete protina.
English: Do not use this medicine after the expiry date which is stated on the carton or blister foil after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli ali pretisnem omotu poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: The efficacy of lesinurad 200 mg once daily was studied in 2 multicentre, randomised, double-blind, placebo-controlled clinical studies in 812 adult patients (11% of these patients were elderly, ≥65 years old) with hyperuricaemia and gout in combination with allopurinol (CLEAR1 and CLEAR2).
Slovenian: Učinkovitost 200 mg lesinurada enkrat na dan so proučili v 2 multicentričnih, randomiziranih, dvojno slepih, s placebom kontroliranih kliničnih študijah pri 812 odraslih bolnikih (11% bolnikov je bilo starejših, starih ≥ 65 let) s hiperurikemijo in protinom, ki so ga prejemali v kombinaciji z alopurinolom (CLEAR1 in CLEAR2).
English: Mild to moderate induction of CYP3A by lesinurad may reduce plasma exposures of co-administered medicinal products that are sensitive substrates of CYP3A.
Slovenian: Blaga do zmerna indukcija CYP3A, ki jo povzroči lesinurad, lahko zmanjša plazemsko izpostavljenost sočasno uporabljenim zdravilom, ki so občutljivi substrati CYP3A.
English: Tissue concentrations of allopurinol have not been reported in humans, but it is likely that allopurinol and oxypurinol will be present in the highest concentrations in the liver and intestinal mucosa where xanthine oxidase activity is high.
Slovenian: Podatkov o koncentraciji alopurinola v tkivih pri ljudeh ni na voljo, vendar je pričakovati, da se alopurinol in oksipurinol v najvišjih koncentracijah nahajata v jetrih in sluznici prebavil, kjer je visoka aktivnost ksantin-oksidaze.
English: Other metabolites of allopurinol include allopurinol-riboside and oxypurinol-7-riboside.
Slovenian: Med druge presnovke alopurinola spadata tudi alopurinol-ribozid in oksipurinol-7-ribozid.
English: Allopurinol is a xanthine-oxidase inhibitor.
Slovenian: Alopurinol je zaviralec ksantin-oksidaze.
English: Cataract, vision disorders (visual impairment and blurred vision), maculopathy
Slovenian: Očesne bolezni katarakta, spremembe vida (motnja vida in zamegljen vid), makulopatija
English: Re-challenge should not be undertaken in patients with hypersensitivity syndrome.
Slovenian: Pri bolnikih s preobčutljivostnim sindromom zdravila ne smemo ponovno uvesti.
English: A causal relationship with lesinurad has not been established.
Slovenian: Vzročna povezanost z lesinuradom ni ugotovljena.
English: Therefore effective inhibition of xanthine oxidase is maintained over a 24 hour period with a single daily dose of allopurinol.
Slovenian: Učinkovito zaviranje ksantin-oksidaze po enem dnevnem odmerku alopurinola je zato ohranjeno preko 24-urnega obdobja.
English: Allopurinol is negligibly bound by plasma proteins and therefore variations in protein binding are not thought to significantly alter clearance.
Slovenian: Alopurinol se na plazemske proteine veže v zanemarljivih količinah, zato ni pričakovati, da bi lahko spremembe v vezavi proteinov pomembno vplivale na očistek.
English: The main metabolite of allopurinol is oxypurinol.
Slovenian: Glavni presnovek alopurinola je oksipurinol.
English: Screening for HLA-B*5801 should be considered before starting treatment with allopurinol in patient subgroups where the prevalence of this allele is known to be high.
Slovenian: Ugotavljanje HLA-B*5801 alela pred uvedbo zdravljenja z alopurinolom bi bilo smotrno pri podskupinah bolnikov, pri katerih je visoka pojavnost tega alela.
English: Oxypurinol is a less potent inhibitor of xanthine oxidase than allopurinol, but the plasma half-life of oxypurinol is far more prolonged.
Slovenian: Oksipurinol je šibkejši zaviralec ksantin-oksidaze kot alopurinol, vendar je razpolovni čas oksipurinola v plazmi mnogo daljši.
English: Do not take Duzallo if: - you are allergic to allopurinol, lesinurad or any of the other ingredients of this medicine (listed in section 6) - you have tumour lysis syndrome - a fast breakdown of cancer cells which can cause high uric acid levels - you have Lesch-Nyhan syndrome - a rare inherited illness that starts in childhood where there is too much uric acid in the blood - your kidneys work very poorly or you have end stage kidney disease (when the kidneys no longer work well enough to meet the body's need) - you have received a kidney transplant - you are on kidney dialysis.
Slovenian: Ne jemljite zdravila Duzallo: - če ste alergični na alopurinol, lesinurad ali katero koli sestavino tega zdravila (navedeno v poglavju 6); - če imate sindrom lize tumorja - hitro razgradnjo rakavih celic, ki lahko povzroči visoko koncentracijo sečne kisline; - če imate Lesch-Nyhanov sindrom - redko podedovano bolezen, ki se začne v otroštvu in jo spremlja zvišana koncentracija sečne kisline v krvi; - če vam ledvice delujejo zelo slabo ali imate končno odpoved ledvic (kadar ledvice več ne delujejo dovolj dobro za potrebe telesa); - če imate presajeno ledvico; - če se zdravite z dializo.
English: The most frequent renal-related adverse reaction was blood creatinine increased (3.7% with lesinurad 200 mg compared to 2.2% with placebo).
Slovenian: Najpogostejši z ledvicami povezani neželeni učinek je bilo zvišanje kreatinina v serumu (3,7% z lesinuradom 200 mg v primerjavi z 2,2% s placebom).
English: Duzallo should not be restarted without another explanation for the serum creatinine abnormalities.
Slovenian: Zdravljenja z zdravilom Duzallo ne smemo ponovno uvesti, če za zvišane vrednosti kreatinina v serumu nimamo alternativne razlage.
English: With administration of allopurinol and cytostatics (e.g. cyclophosphamide, doxorubicin, bleomycin, procarbazine, alkylating agents), blood dyscrasias occur more frequently than when these active substances are administered alone.
Slovenian: Ob uporabi alopurinola in citostatikov (npr. ciklofosfamida, doksorubicin, bleomicina, prokarbazina, alkilirajoče učinkovine), se lahko pojavijo krvne diskrazije pogosteje, kot pri jemanju teh učinkovin samih.
English: Other organs may also be affected (e.g. liver, lungs, kidneys, pancreas, myocardium, and colon).
Slovenian: Lahko so prizadeti tudi drugi organi (npr. jetra, pljuča, ledvice, trebušna slinavka, miokard in debelo črevo).
English: The primary efficacy endpoint in both CLEAR1 and CLEAR2 was the proportion of patients achieving a serum uric acid target level of less than 6 mg/dL by Month 6.
Slovenian: Primarni cilj študije učinkovitosti v študijah CLEAR1 in CLEAR2 je bil delež bolnikov, ki so do 6. meseca dosegli ciljno koncentracijo sečne kisline manj kot 6 mg/dl.
English: If you take more of this medicine than you should, talk to a doctor or go to the nearest hospital immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Duzallo, kot bi smeli Če ste vzeli več zdravila, kot bi smeli, se posvetujte z zdravnikom ali pojdite v najbližjo bolnišnico.
English: Post-hoc analyses in a subgroup of patients with high cardiovascular risk at baseline (as defined by transient ischemic attack, angina pectoris, heart failure, myocardial infarction, peripheral vascular disease and/or stroke), showed that the incidence of MACE was 0/39 for placebo and 2/43 for lesinurad 200 mg.
Slovenian: Post hoc analize v podskupini bolnikov z velikim izhodiščnim srčno-žilnim tveganjem (opredeljevali so ga tranzitorna ishemična ataka, angina pektoris, srčno popuščanje, miokardni infarkt, periferna žilna bolezen in/ali možganska kap) so pokazale, da je bila pojavnost MACE med uporabo s placebom 0/39 in z 200 mg lesinurada
English: Duzallo which contains lesinurad as active substance causes an increase in renal uric acid excretion, which may lead to transient increases in serum creatinine, renal-related adverse reactions and kidney stones (see section 5.1).
Slovenian: Zdravilo Duzallo, ki vsebuje učinkovino lesinurad, poveča izločanje sečne kisline v ledvicah; to lahko povzroči prehodno zvišanje kreatinina v serumu, neželene učinke na ledvicah in ledvične kamne (glejte poglavje 5.1).