FrancophonIA/ELRC3.0 huggingface dataset:
English: Following oral administration of 1 mg/kg body weight telmisartan to cats, plasma-concentration-time curves of the parent compound are characterised by rapid absorption, with maximum plasma concentrations (Cmax) achieved after 0.5 hours (tmax).
Croatian: Nakon peroralne primjene telmisartana u mačaka u dozi od 1 mg/kg tjelesne mase, krivulje plazmatske koncentracije osnovnog spoja u odnosu na vrijeme, obilježava brza apsorpcija uz maksimalnu koncentraciju u plazmi (Cmax) postignutoj nakon 0,5 sati (tmax).
English: If SBP is below the target or if there are concurrent signs of hypotension, please refer to section 4.5.
Croatian: Ako je sistolički krvni tlak niži od ciljane vrijednosti ili ako postoje trenutačni znakovi hipotenzije, vidjeti dio 4.5.
English: Pack size of one plastic bottle filled with 35 ml and one measuring syringe.
Croatian: Veličina pakovanja od jedne plastične bočice sadržava 35 ml i jednu mjernu štrcaljku.
English: Pack sizes of one plastic bottle filled with 30 ml or one plastic bottle filled with 100 ml.
Croatian: Veličine pakovanja: jedna plastična bočica sadržaja 30 ml ili jedna plastična bočica sadržaja 100 ml. 1 mjerna štrcaljka
English: If SBP is below the target or if there are concurrent signs of hypotension, please refer to the “Special warnings” section.
Croatian: Ako je sistolički krvni tlak niži od ciljane vrijednosti ili postoje trenutačni znakovi hipotenzije, vidjeti dio „Posebna upozorenja“.
English: The target SBP range is between 120 and 140 mmHg.
Croatian: Ciljani raspon sistoličkog krvnog tlaka iznosi od 120 do 140 mmHg.
English: Carton for 30 ml and 100 ml
Croatian: Kutija sa 30 ml i 100 ml
English: Effects observed at the recommended treatment dose included mild decreases in red blood cell counts.
Croatian: Učinci opaženi uz preporučenu terapijsku dozu uključivali su blago smanjenje broja crvenih krvnih stanica.
English: Do not use during pregnancy or lactation.
Croatian: Ne primjenjivati za vrijeme graviditeta ili laktacije.
English: One HDPE bottle filled with 35 ml.
Croatian: Jedna HDPE bočica sadržava 35 ml.
English: Pack size of one bottle and one measuring syringe.
Croatian: Veličina pakovanja s jednom bočicom i jednom mjernom štrcaljkom.
English: Do not use during pregnancy and lactation.
Croatian: Ne primjenjivati za vrijeme graviditeta i laktacije.
English: In the event that hypotension (low blood pressure) does occur, symptomatic treatment, e.g. fluid therapy, should be provided.
Croatian: U slučaju pojave hipotenzije (niskog krvnog tlaka) potrebno je primijeniti simptomatsko liječenje, npr. terapiju tekućinom.
English: During concomitant therapy with amlodipine at the recommended dose, no clinical evidence of hypotension was observed.
Croatian: Za vrijeme istodobne terapije amlodipinom u preporučenoj dozi nisu bili opaženi klinički znakovi hipotenzije.
English: Interaction with other medicinal products and other forms of interaction During concomitant therapy with amlodipine at the recommended dose no clinical evidence of hypotension was observed.
Croatian: Interakcije s drugim medicinskim proizvodima i drugi oblici interakcija: Za vrijeme istodobne terapije amlodipinom u preporučenoj dozi nisu bili opaženi klinički znakovi hipotenzije.
English: SPECIFIC PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCTS OR WASTE MATERIALS, IF ANY
Croatian: 12. POSEBNE MJERE OPREZA PRI ODLAGANJU NEUPOTRIJEBLJENIH PROIZVODA ILI OTPADNIH MATERIJALA, AKO IH IMA
English: Hypokalaemia is associated with CKD, however telmisartan does not affect potassium excretion, as shown in the clinical field trial in cats.
Croatian: Hipokalijemija je povezana s kroničnom bubrežnom bolešću, međutim, kako pokazuju klinička terenska ispitivanja na mačkama, telmisartan ne utječe na izlučivanje kalija.
English: During concomitant therapy with amlodipine at the recommended dose for the reduction of proteinuria associated with chronic kidney disease (CKD) in cats no clinical evidence of hypotension was observed.
Croatian: Za vrijeme istodobne terapije amlodipinom u preporučenoj dozi za smanjenje proteinurije povezane s kroničnom bubrežnom bolešću u mačaka nisu bili opaženi klinički znakovi hipotenzije.
English: The syringe fits onto the bottle and has a kg-body weight scale.
Croatian: Štrcaljka pristaje na bočicu i ima označene mjere za kilograme tjelesne mase.
English: Bottle for 100 ml
Croatian: Bočica, 100 ml
English: Bottle for 30 ml
Croatian: Bočica, 30 ml
English: Substances acting on the RAAS may lead to a reduction in glomerular filtration rate and worsening renal function in cats with severe kidney disease.
Croatian: Tvari koje djeluju na sustav renin-angiotenzin-aldosteron (RAAS) mogu uzrokovati smanjenje brzine glomerularne filtracije i pogoršanje bubrežne funkcije u mačaka s teškom bubrežnom bolešću.
English: Bottle for 35 ml
Croatian: Bočica, 35 ml
English: In cats with hypertension it is good clinical practice to regularly monitor blood pressure.
Croatian: Dobra je klinička praksa redovito nadzirati krvni tlak u mačaka s hipertenzijom.
English: 1 measuring syringe
Croatian: 1 mjerna štrcaljka
English: Each bottle is closed with an LDPE plug-in adapter and a tamper-proof child resistant closure.
Croatian: Svaka bočica je zatvorena LDPE nastavkom s otvorom za štrcaljku i zatvaračem sigurnim za djecu.
English: The syringe fits onto the bottle and has a ml scale.
Croatian: Štrcaljka pristaje na bočicu i ima označene mjere u mililitrima.
English: DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION
Croatian: DOZIRANJE ZA SVAKU CILJNU VRSTU ŽIVOTINJA, NAČIN I PUT PRIMJENE Peroralna primjena.
English: In the event that hypotension does occur, symptomatic treatment, e.g. fluid therapy, should be provided.
Croatian: U slučaju pojave hipotenzije potrebno je primijeniti simptomatsko liječenje, npr. terapiju tekućinom.
English: Push down and turn cap to open the bottle.
Croatian: Za otvaranje bočice zatvarač gurnite prema dolje i okrenite.
English: Benzalkonium chloride
Croatian: 10 mg benzalkonijev klorid
English: After administration of up to 2.5 times the initial recommended dose for 6 months to young adult healthy cats, adverse reactions observed were consistent with those mentioned in section 4.6.
Croatian: Nakon primjene doze do 2,5 puta veće od početne preporučene tijekom 6 mjeseci, u mladih odraslih zdravih mačaka nuspojave su bile dosljedne onima navedenim u dijelu „Nuspojave“.
English: PSURs:
Croatian: NUSPOJAVE
English: The solution should be given using the measuring syringe provided in the package.
Croatian: Otopinu treba davati s pomoću mjerne štrcaljke priložene u pakovanju.
English: In a further clinical trial in cats with hypertension a reduction in mean systolic blood pressure was achieved with a dose of 2 mg/kg.
Croatian: Gelöscht: , povezanom s Gelöscht: nije manja od kliničkom ispitivanju u mačaka s hipertenzijom postignuto je sniženje prosječnog sistoličkog krvnog tlaka dozom od 2 mg/kg.
English: Mild and transient gastrointestinal signs such as vomiting and diarrhoea associated with product administration have been observed commonly in a clinical study.
Croatian: U kliničkom ispitivanju često su opaženi blagi i prolazni gastrointestinalni znakovi povezani sa primjenom proizvoda poput povraćanja i proljeva povezani s primjenom proizvoda.
English: Attach the dosing syringe to the plug-in adapter of the bottle by gently pushing.
Croatian: Laganim guranjem štrcaljke za doziranje u nastavak bočice s otvorom, pričvrstite štrcaljku na bočicu.
English: No drug-drug interactions are known from available data in cats with CKD for the use of telmisartan and other medicinal products that interfere with RAAS (such as ARBs or ACEis).
Croatian: Na temelju dostupnih podataka, u mačaka s kroničnom bubrežnom bolešću, nema poznatih interakcija medicinskih proizvoda, kada se upotrebljavaju telmisartan i drugi medicinski proizvodi koji djeluju na sustav renin-angiotenzin-aldosteron (kao što su blokatori angiotenzinskih receptora (ARB) ili inhibitori acetilkolinesteraze (ACEi).
English: After administration of up to 5 times the recommended dose for 6 months to young adult healthy cats, adverse reactions observed were consistent with those mentioned in section 4.6.
Croatian: Nakon primjene doze do 5 puta veće od preporučene tijekom 6 mjeseci u mladih, odraslih, zdravih mačaka opažene nuspojave bile su u skladu s navedenim u dijelu „Nuspojave“.
English: PACKAGE LEAFLET: Semintra 10 mg/ml oral solution for cats
Croatian: UPUTA O VMP: Semintra 10 mg/ml peroralna otopina za mačke
English: Administration of the product at overdose (3 to 5 times of the recommended dose for 6 months) resulted in marked reductions in blood pressure, decreases in red blood cell count (effects attributable to the pharmacological activity of the product) and increases in Blood Urea Nitrogen (BUN; nitrogen containing waste products in the blood).
Croatian: Primjena proizvoda u prekomjernoj dozi (3 do 5 puta većoj od preporučene tijekom 6 mjeseci) rezultirala je izrazitim sniženjem krvnog tlaka, smanjenjem broja crvenih krvnih stanica (učinci koji se mogu pripisati farmakološkoj aktivnosti proizvoda) i povećanjem urea nitrata u krvi (BUN; otpadne tvari u krvi koje sadrže dušik).
English: PACKAGE LEAFLET: Semintra 4 mg/ml oral solution for cats
Croatian: UPUTA O VMP: Semintra 4 mg/ml peroralna otopina za mačke
English: Administration of the product at overdose (up to 2.5 times the recommended dose for 6 months) resulted in marked reductions in blood pressure, decreases in red blood cell count (effects attributable to the pharmacological activity of the product) and increases in Blood Urea Nitrogen (BUN).
Croatian: Primjena proizvoda u prekomjernoj dozi (do 2,5 puta većoj od preporučene tijekom 6 mjeseci) rezultirala je izrazitim sniženjem krvnog tlaka, smanjenjem broja crvenih krvnih stanica (učinci koji se mogu pripisati farmakološkoj aktivnosti proizvoda) i povećanjem urea nitrata u krvi (BUN).
English: Semintra 10 mg/ml oral solution for cats
Croatian: Semintra 10 mg/ml peroralna otopina za mačke
English: Very limited data are available regarding interactions in cats with hypertension between telmisartan and other medicinal products that lower blood pressure (such as amlodipine) or interfere with RAAS (such as ARBs or ACEis).
Croatian: O interakcijama između telmisartana i drugih medicinskih proizvoda koji snižavaju krvni tlak (kao što je amlodipin) ili djeluju na sustav renin-angiotenzin-aldosteron (RAAS) (kao što su blokatori angiotenzinskih receptora (ARB) ili inhibitori acetilkolinesteraze (ACEi) u mačaka s hipertenzijom dostupno je vrlo malo podataka.
English: Semintra 4 mg/ml oral solution for cats
Croatian: Semintra 4 mg/ml peroralna otopina za mačke
English: Carton for 35 ml
Croatian: Kutija sa 35 ml
English: Semintra 10 mg/ml oral solution for cats Telmisartan
Croatian: Semintra 10 mg/ml peroralna otopina za mačke Telmisartan
English: Semintra 4 mg/ml oral solution for cats telmisartan
Croatian: Semintra 4 mg/ml peroralna otopina za mačke Telmisartan
English: Semintra 4 mg/ml oral solution for cats Telmisartan
Croatian: Semintra 4 mg/ml peroralna otopina za mačke telmisartan
English: STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENT(S)
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV DJELATNE TVARI I DRUGIH SASTOJAKA
English: As determined by AUC, food consumption does not affect the overall extent of absorption of telmisartan.
Croatian: Unos hrane ne utječe na sveukupni opseg apsorpcije telmisartana, što je određeno površinom ispod krivulje.
English: Symptomatic treatment, e.g. fluid therapy, should be provided in case of any clinical signs of hypotension.
Croatian: U slučaju bilo kojih kliničkih znakova hipotenzije potrebno je primijeniti simptomatsko liječenje, npr. terapiju tekućinom.
English: The combination of agents targeting the RAAS may alter renal function.
Croatian: Kombinacija tvari koje djeluju na sustav renin-angiotenzinaldosteron može utjecati na bubrežnu funkciju.
English: Use entire content.
Croatian: Iskoristite cjelokupni sadržaj.
English: However, please tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Croatian: Svejedno, obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući i one koje ste nabavili bez recepta.
English: The condition may manifest itself as an insufficient clinical response.
Croatian: To se stanje može očitovati kao nedostatan klinički odgovor.
English: Make sure that no blood enters the syringe.
Croatian: Provjerite da u štrcaljku ne ulazi krv.
English: • Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist have told you.
Croatian: Uvijek primijenite ovaj lijek točno onako kako je opisano u ovoj uputi ili kako Vam je rekao Vaš liječnik ili ljekarnik.
English: Overall, 9 out of 60 (15%) developed inhibitors.
Croatian: Ukupno je 9 od 60 (15%) bolesnika razvilo inhibitore.
English: • If you are allergic to octocog alfa or to any of the other ingredients of this medicine (listed in section 6 and end of section 2).
Croatian: • ako ste alergični na oktokog alfa ili neki drugi sastojak ovog lijeka (naveden u dijelu 6 i na kraju dijela 2)
English: During continuous infusion, infusion bags should be changed every 24 hours.
Croatian: Infuzijske vrećice tijekom kontinuirane infuzije potrebno je mijenjati svaka 24 sata.
English: In such cases, it is recommended that a specialised haemophilia centre be contacted.
Croatian: U takvim slučajevima, preporučuje se kontaktirati specijalizirani centar za hemofiliju.
English: Paediatric population The listed warnings and precautions apply both to adults and children.
Croatian: Pedijatrijska populacija Navedena upozorenja i mjere opreza vrijede kako za odrasle, tako i za djecu.
English: Rarely, inhibitors may develop after the first 100 exposure days.
Croatian: Inhibitori se u rijetkim slučajevima mogu razviti nakon prvih 100 dana izloženosti.
English: Determine the point of injection and prepare antiseptically.
Croatian: Odredite mjesto injiciranja i pripremite ga antiseptički.
English: Warm both unopened vials in your hands to a comfortable temperature (do not exceed 37 °C).
Croatian: Obje neotvorene bočice ugrijte rukama do ugodne temperature (ne više od 37 °C).
English: Filtering is achieved by using the Mix2Vial adapter.
Croatian: Filtriranje se postiže pomoću uporabe adaptera Mix2vial.
English: Clearance: 3 ml/h/kg
Croatian: Klirens: 3 ml/h/kg
English: Imed Poland sp. z.o.o.
Croatian: Imed Poland sp. z.o.o. Tel.
English: If any component of the package is opened or damaged, do not use it.
Croatian: Ako je bilo koji dio u pakiranju otvoren ili oštećen, nemojte ga uporabiti.
English: Frequencies have been evaluated according to the following convention: very common: (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: This medicine should be injected intravenously over several minutes.
Croatian: Ovaj se lijek treba injicirati intravenski tijekom nekoliko minuta.
English: The risk of developing inhibitors is correlated to the exposure to factor VIII and to genetic factors among others, this risk being highest within the first 20 exposure days.
Croatian: Rizik razvoja inhibitora u korelaciji je, između ostalog, s izloženošću faktoru VIII i genetskim faktorima, a rizik je najveći tijekom prvih 20 dana izloženosti.
English: • If you have been told you have heart disease or are at risk for heart disease, tell your doctor or pharmacist.
Croatian: • Ako su Vam rekli da imate srčanu bolest ili rizik za razvoj srčane bolesti, obavijestite svog liječnika ili ljekarnika.
English: • This medicine must not be mixed with other infusion solutions.
Croatian: Ovaj lijek se ne smije miješati s drugim infuzijskim otopinama.
English: Therefore, it is recommended to monitor all patients carefully for inhibitor occurrence following any product switch.
Croatian: Stoga, preporučuje se pomno pratiti sve bolesnike na pojavu inhibitora nakon bilo koje promjene lijeka.
English: Example for calculation of infusion rate for continuous infusion after initial bolus injection
Croatian: Primjer izračuna brzine infuzije za kontinuiranu infuziju nakon početne bolus injekcije.
English: Overall list of possible side effects:
Croatian: Ukupni popis mogućih nuspojava: Vrlo često:
English: In patients with high levels of inhibitor, factor VIII therapy may not be effective and other therapeutic options should be considered.
Croatian: U bolesnika s visokim razinama inhibitora, terapija faktorom VIII ne mora biti učinkovita pa se moraju razmotriti druge terapijske mogućnosti.
English: Follow the directions given by your doctor closely and use the instructions below as a guide:
Croatian: Strogo se pridržavajte uputa liječnika te se uputama u nastavku poslužite kao smjernicama:
English: One patient was lost to follow up and one patient developed a low-titre inhibitor during post study follow-up.
Croatian: Jedan bolesnik je bio izgubljen iz praćenja, a jedan je razvio nizak titar inhibitora tijekom praćenja nakon ispitivanja.
English: Draw air into an empty, sterile syringe.
Croatian: Uvucite zraku u praznu sterilnu štrcaljku.
English: • Your doctor may carry out tests to ensure that your current dose of this medicine provides adequate factor VIII levels.
Croatian: • Liječnik može obaviti pretrage da bi bili sigurni da se s trenutnom dozom ovog lijeka postižu odgovarajuće razine faktora VIII.
English: Helixate NexGen can be infused by continuous infusion.
Croatian: Helixate NexGen može se infundirati kontinuiranom infuzijom.
English: Helixate NexGen has no influence on the ability to drive or to use machines.
Croatian: Helixate NexGen ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Solvent Water for injections, sterilised.
Croatian: Otapalo Voda za injekcije, sterilizirana.
English: The vial contains a dry white to slightly yellow powder or cake, as well as water for injections to be used to reconstitute the contents of the vial.
Croatian: Bočica sadrži suhi bijeli do žućkasti prašak ili kolačić, kao i vodu za injekciju koja služi za pripremu za primjenu sadržaja bočice.
English: For the calculation of the initial infusion rate, clearance can be obtained by performing a pre-surgery decay curve, or by starting from an average population value (3.0-3.5 ml/h/kg) and then adjust accordingly.
Croatian: Za izračun početne brzine infuzije klirens se može postići izradom preoperativne krivulje opadanja ili započeti s prosječnom populacijskom vrijednošću (3,0 - 3,5 ml/h/kg), a zatim je prilagođavati.
English: Marketing Studies)*
Croatian: MLB)*
English: Allergic type hypersensitivity reactions are possible with Helixate NexGen.
Croatian: Reakcije alergijskog tipa preosjetljivosti moguće su na lijek Helixate NexGen.
English: The table presented below is according to the MedDRA system organ classification (SOC and Preferred Term Level).
Croatian: Tablični popis nuspojava Sljedeća tablica prikazana je prema MedDRA klasifikaciji organskih sustava (SOC i preporučeni izrazi).
English: In general, all patients treated with coagulation factor VIII products should be carefully monitored for the development of inhibitors by appropriate clinical observations and laboratory tests.
Croatian: Općenito, svim bolesnicima liječenim lijekovima koji sadrže koagulacijski faktor VIII potrebno je pomno nadzirati razvoj inhibitora odgovarajućim kliničkim metodama praćenja i laboratorijskim testovima.
English: In patients where immune tolerance was achieved the bleedings could be prevented or controlled with Helixate NexGen again, and the patients could continue with prophylactic treatment as maintenance therapy.
Croatian: U bolesnika u kojih se postigla imunološka tolerancija, krvarenja su se ponovno mogla spriječiti ili kontrolirati pomoću lijeka Helixate NexGen, a bolesnici su mogli nastaviti s profilaktičkim liječenjem kao terapijom održavanja.
English: Infusion rate for 75 kg patient ml/h
Croatian: Brzina infuzije za bolesnika težine 75 kg ml/h
English: Antibodies (Inhibitors)
Croatian: Protutijela (inhibitori)
English: Infusion rate (in IU/kg/h) = Clearance (in ml/h/kg) × desired factor VIII level (in IU/ml)
Croatian: Brzina infuzije (u IU/kg/h) = klirens (u ml/h/kg) × željena razina faktora VIII (u IU/ml)
English: Factor VIII inhibitors are antibodies in the blood which block the factor VIII you are using, and makes it less effective to prevent and control bleeding.
Croatian: Inhibitori faktora VIII su protutijela u krvi koja blokiraju faktor VIII koji uzimate te smanjuju njegovu učinkovitost u sprječavanju i zaustavljanju krvarenja.
English: The specific activity of Helixate NexGen is approximately 4000 IU/mg protein.
Croatian: Specifična je aktivnost lijeka Helixate NexGen približno 4000 IU/mg proteina.
English: The reconstituted medicinal product is a clear and colourless solution.
Croatian: Pripremljeni lijek je bistra i bezbojna otopina.
English: • If your bleeding is not being controlled with your usual dose of this medicine, consult your doctor immediately.
Croatian: • Ako se uobičajenom dozom ovog lijeka ne zaustavlja krvarenje, odmah se obratite liječniku.
English: Use only the medical devices for reconstitution and administration that are provided with each package of this medicine.
Croatian: Za pripremu i primjenu koristite samo medicinske proizvode koji su priloženi u svakom pakiranju ovog lijeka.
English: However, during in vitro studies, the chemical and physical in-use stability has been demonstrated for 24 hours at 30°C in PVC bags for continuous infusion".
Croatian: Međutim, tijekom ispitivanja in vitro, pokazano je da kemijska i fizička stabilnost lijeka u primjeni traje 24 sata na temperaturi od 30 °C u PVC vrećicama za kontinuiranu infuziju.
English: Inject the solution intravenously over several minutes, keeping an eye on the position of the needle.
Croatian: Ubrizgavajte otopinu u venu kroz nekoliko minuta, pazeći cijelo vrijeme na položaj igle.
English: You may have developed factor VIII inhibitors and your doctor may carry out tests to confirm this.
Croatian: Moguće je da je došlo do razvoja inhibitora faktora VIII te će liječnik obaviti pretrage kako bi to potvrdio.
English: Continuous Infusion
Croatian: Kontinuirana infuzija
English: • Proceed with your next dose immediately and continue at regular intervals as advised by your doctor.
Croatian: • Odmah uzmite sljedeću dozu te nastavite uzimati lijek u redovitim vremenskim razmacima koje Vam je odredio liječnik.
English: Make sure that you only pull away the blister package and not the Mix2Vial set.
Croatian: Pazite da povučete samo blister pakiranje, a ne i komplet uređaja
English: After the initial 24 hours of continuous infusion, the clearance should be recalculated every day using the steady state equation with the measured FVIII level and the rate of infusion using the following equation: clearance = infusion rate/actual FVIII level.
Croatian: Nakon početnih 24 sata kontinuirane infuzije potrebno je svaki dan izračunavati klirens pomoću jednadžbe stacionarnog stanja s izmjerenom razinom faktora VIII te brzinom infuzije, i to sljedećom jednadžbom: klirens = brzina infuzije/stvarna razina faktora VIII
English: For long term prophylaxis against bleeding in patients with severe haemophilia A, the usual doses are 20 to 40 IU of Helixate NexGen per kg body weight at intervals of 2 to 3 days.
Croatian: Za dugotrajnu profilaksu krvarenja u bolesnika s teškom hemofilijom A uobičajene su doze 20 do 40 IU lijeka Helixate NexGen po kilogramu tjelesne težine u razmacima od 2 do 3 dana.