FrancophonIA/ELRC3.0 huggingface dataset:
English: EMEND 40 mg is indicated for the prevention of postoperative nausea and vomiting (PONV) in adults.
Croatian: EMEND 40 mg je indiciran za prevenciju postoperativne mučnine i povraćanja (engl.
English: The powder for oral suspension contains sucrose and lactose.
Croatian: Prašak za oralnu suspenziju sadrži saharozu i laktozu.
English: * The confidence intervals were calculated with no adjustment for age category (< 55 years, ≥ 55 years) and investigator group, which were included in the primary analysis of odds ratios and logistic models.
Croatian: * Intervali pouzdanosti izračunati su bez prilagođavanja prema dobi (<55 godina, ≥55 godina) i ispitivaču, a koji su obuhvaćeni primarnom analizom omjera šansi i logističkih modela.
English: It is not known whether aprepitant is excreted in human milk; therefore, breast-feeding is not recommended during treatment with EMEND.
Croatian: Nije poznato izlučuje li se aprepitant u majčino mlijeko u ljudi, stoga se ne preporučuje dojenje tijekom liječenja lijekom EMEND.
English: Methylprednisolone: Although the concomitant administration of methylprednisolone with the single 40 mg dose of aprepitant has not been studied, a single 40 mg dose of aprepitant produces a weak inhibition of CYP3A4 and it is not expected to alter the plasma concentrations of methylprednisolone to a clinically significant degree.
Croatian: Iako nije ispitivana istodobna primjena metilprednizolona s jednokratnom dozom od 40 mg aprepitanta, jedna doza od 40 mg aprepitanta uzrokuje slabu inhibiciju CYP3A4 i ne očekuje se da bi promijenila koncentracije metilprednizolona u plazmi do klinički značajnog stupnja.
English: Further studies evaluating the use of aprepitant in paediatric patients are on-going (see section 4.2 for information on paediatric use).
Croatian: Daljnja ispitivanja primjene aprepitanta u pedijatrijskih bolesnika su u tijeku (vidjeti dio 4.2 za podatke o pedijatrijskoj primjeni).
English: Titanium dioxide (E 171) Indigo carmine (E 132)
Croatian: Ovojnica kapsule želatina titanijev dioksid (E 171) indigo karmin (E 132)
English: The potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolised via CYP3A4 (alprazolam, triazolam) should be considered when co-administering these medicinal products with EMEND 165 mg.
Croatian: Treba uzeti u obzir mogući učinak povišenih koncentracija midazolama, ili drugih benzodiazepina koji se metaboliziraju putem CYP3A4 (aprazolam, triazolam) u plazmi, prilikom istodobne primjene tih lijekova s lijekom EMEND 165 mg.
English: Dexamethasone: The usual oral dexamethasone dose should be reduced by approximately 50 % when co-administered with EMEND 125 mg/80 mg regimen.
Croatian: Deksametazon: uobičajenu peroralnu dozu deksametazona treba sniziti za približno 50% primjenjuje li se istodobno s režimom liječenja lijekom EMEND 125 mg/80 mg.
English: Hold the EMEND powder for oral suspension sachet upright and shake the contents to the bottom before opening the sachet.
Croatian: Prije nego što otvorite vrećicu lijeka EMEND prašak za oralnu suspenziju, držite je uspravno i protresite kako bi sav sadržaj vrećice pao na dno.
English: Do not give EMEND 40 mg to children and adolescents under 18 years of age, because the 40 mg capsules have not been studied in this population.
Croatian: Nemojte davati EMEND 40 mg djeci i adolescentima mlađim od 18 godina, zato što kapsule od 40 mg nisu ispitane u ovoj populaciji.
English: PET/aluminium/LLDPE sachets
Croatian: PET/aluminij/LLDPE vrećice.
English: EMEND 80 mg capsule
Croatian: EMEND 80 mg kapsula
English: Fill the 5 mL oral dispenser with 4.6 mL of water from the mixing cup.
Croatian: Napunite oralni dozator od 5 ml s 4,6 ml vode iz čaše za miješanje.
English: Studies evaluating the use of aprepitant in paediatric patients are on-going (see section 4.2 for information on paediatric use).
Croatian: Ispitivanja primjene aprepitanta u pedijatrijskih bolesnika su u tijeku (vidjeti dio 4.2 za podatke o primjeni u pedijatrijskih bolesnika).
English: In a juvenile toxicity study in dogs treated from post natal day 14 to day 42, a decreased testicular weight and Leydig cell size were seen in the males at 6 mg/kg/day and increased uterine weight, hypertrophy of the uterus and cervix, and oedema of vaginal tissues were seen in females from 4 mg/kg/day.
Croatian: U ispitivanju toksičnosti na štenadi liječenoj od 14. do 42. postnatalnog dana opažena je smanjena težina testisa i veličina Leydigovih stanica u mužjaka kod doze od 6 mg/kg na dan i povećana težina uterusa, hipertrofija uterusa i cerviksa te edem vaginalnog tkiva u ženki kod doza od 4 mg/kg na dan.
English: The most common adverse reaction reported at a greater incidence in adults treated with 40 mg aprepitant (1.1 %) than with ondansetron (1.0 %) was ALT increased.
Croatian: Najčešće prijavljena nuspojava, zabilježena u većoj incidenciji u odraslih koji su primali 40 mg aprepitanta (1,1%) nego u bolesnika koji su primali ondanzetron (1,0%) bio je povišeni ALT.
English: * - Overall phase
Croatian: * - cijelo razdoblje
English: Always take this medicine or give this medicine to the child exactly as the doctor, pharmacist or nurse has told you.
Croatian: Uvijek uzmite ovaj lijek ili dajte ovaj lijek djetetu točno onako kako su Vam rekli liječnik, ljekarnik ili medicinska sestra.
English: • Use the 5 mL oral dispenser to measure 4.6 mL of water, which is added into the mixing cup.
Croatian: • Pomoću oralnog dozatora od 5 ml izmjerite 4,6 ml vode, koja se dodaje u čašu za miješanje.
English: EMEND 125 mg capsule
Croatian: EMEND 125 mg kapsula
English: The mean peak plasma concentration (Cmax) of aprepitant occurred at approximately 4 hours (Tmax).
Croatian: Srednja vršna koncentracija aprepitanta u plazmi (Cmax) postignuta je nakon otprilike 4 sata (tmax).
English: Occupancy of brain NK1 receptors by aprepitant correlate well with aprepitant plasma concentrations.
Croatian: Vezanje aprepitanta za NK1 receptore u mozgu je povezana s koncentracijama aprepitanta u plazmi.
English: The recommended dose is 125 mg orally once daily one hour before start of chemotherapy on Day 1 and 80 mg orally once daily on Days 2 and 3 in the morning.
Croatian: Preporučena doza je 125 mg peroralno jedanput na dan jedan sat prije početka kemoterapije 1. dan liječenja te doza od 80 mg peroralno jedanput dnevno 2. dan i 3. dan ujutro.
English: Co-administration of EMEND with active substances that are known to be metabolized by CYP2C9 (e.g., phenytoin, warfarin), may result in lower plasma concentrations of these active substances.
Croatian: Istodobna primjena lijeka EMEND s djelanim tvarima za koje se zna da se metaboliziraju putem CYP2C9 (npr. fenitoinom i varfarinom) može sniziti koncentraciju tih djelatnih tvari u plazmi.
English: After reconstitution:
Croatian: Nakon pripreme za primjenu:
English: Given the short duration of increased exposure, dose reduction of the immunosuppressant based on Therapeutic Dose Monitoring is not recommended on the day of and the day after administration of EMEND 165 mg.
Croatian: Therepeutic Dose Monitoring) i obzirom na kratko trajanje i povećanje izloženosti, ne preporučuje se smanjivati dozu imunosupresiva na dan i dan nakon primjene lijeka EMEND 165 mg.
English: Gender: Following oral administration of a single 125 mg dose of aprepitant, the Cmax for aprepitant is 16 % higher in females as compared with males.
Croatian: Spol: Nakon jednokratne peroralne primjene doze aprepitanta od 125 mg, Cmax aprepitanta bio je 16% viši u žena nego u muškaraca.
English: Single-use carton
Croatian: Kutija za jednokratnu primjenu
English: The potential for effects of aprepitant on fertility has not been fully characterised because exposure levels above the therapeutic exposure in humans could not be attained in animal studies.
Croatian: Mogući učinci aprepitanta na plodnost nisu u potpunosti opisani jer se u ispitivanjima na životinjama nisu mogle postići razine izloženosti iznad terapijske izloženosti u ljudi.
English: Following oral administration of a single 40 mg dose of EMEND in the fasted state, the AUC0- (mean ± SD) was 8.0 ± 2.1 µg • h/mL and the Cmax was 0.7 ± 0.24 µg/mL.
Croatian: Nakon peroralne primjene jedne EMEND 40 mg doze natašte, AUC0-∞ aprepitanta (srednja vrijednost ± SD) iznosio je 8,0 ± 2,1 µg • h/ml, a Cmax je iznosila 0,7 ± 0,24 µg/ml.
English: In a randomised, parallel, double-blind, active-controlled study, fosaprepitant 150 mg (N=1,147) was compared with a 3-day aprepitant regimen (N=1,175) in adult patients receiving a HEC regimen that included cisplatin (≥ 70 mg/m2).
Croatian: U randomiziranom, paralelnom, dvostruko slijepom ispitivanju kontroliranom aktivnim komparatorom, fosaprepitant u dozi od 150 mg (N=1147) uspoređen je s trodnevnim režimom liječenja aprepitantom (N=1175) u odraslih bolesnika koji su primali jako emetogenu kemoterapiju cisplatinom (≥70 mg/m2).
English: EMEND powder for oral suspension contains sucrose and lactose.
Croatian: EMEND prašak za oralnu suspenziju sadrži saharozu i laktozu.
English: Aprepitant regimen (N= 433)
Croatian: Režim s aprepitantom (N= 433)
English: EMEND causes a transient mild induction of CYP2C9, CYP3A4 and glucuronidation approximately one week after treatment.
Croatian: EMEND uzrokuje prolaznu blagu indukciju CYP2C9, CYP3A4 i glukuronidaciju približno tjedan dana nakon primjene.
English: Concomitant administration of EMEND with active substances that strongly induce CYP3A4 activity (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital) should be avoided as the combination results in reductions of the plasma concentrations of aprepitant that may result in decreased efficacy of EMEND.
Croatian: Treba izbjegavati istodobnu primjenu lijeka EMEND i djelatnih tvari koje snažno induciraju aktivnost CYP3A4 (npr. rifampicin, fenitoin, karbamazepin, fenobarbital) jer takva kombinacija dovodi do sniženja koncentracije aprepitanta u plazmi, što može dovesti do smanjenja djelotvornosti lijeka EMEND.
English: Take the capsule 1 hour before you start your chemotherapy session.
Croatian: Uzmite kapsulu 1 sat prije kemoterapije.
English: Always take EMEND together with other medicines, to prevent nausea and vomiting.
Croatian: Uvijek uzmite EMEND zajedno s drugim lijekovima kako biste spriječili mučninu i povraćanje.
English: The safety and efficacy of EMEND 165 mg in children and adolescents below 18 years of age has not been established.
Croatian: Sigurnost i djelotvornost primjene lijeka EMEND 165 mg u djece i adolescenata mlađih od 18 godina nije još ustanovljena.
English: - If chemotherapy is given, take EMEND 1 hour before you start your chemotherapy session.
Croatian: Ako se daje kemoterapija, uzmite EMEND 1 sat prije početka kemoterapije.
English: Do not use this medicine after the expiry date which is stated on the carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake "EXP".
English: Hepatic impairment: Mild hepatic impairment (Child-Pugh class A) does not affect the pharmacokinetics of aprepitant to a clinically relevant extent.
Croatian: Oštećenje funkcije jetre: Utjecaj blagog oštećenja funkcije jetre (Child-Pugh stadij A) na farmakokinetiku aprepitanta nije klinički značajan.
English: The daily dose of dexamethasone on Days 1 and 2 should be reduced by approximately 50 % when co-administered with EMEND 165 mg on Day 1 to achieve exposures of dexamethasone similar to those obtained when given without EMEND 165 mg.
Croatian: Uobičajenu dozu deksametazona 1. i 2. dan liječenja treba sniziti za približno 50% primjenjuje li se istodobno s lijekom EMEND 165 mg kako bi izloženost deksametazona bila približno slična onoj bez primjene lijeka EMEND 165 mg.
English: Microcrystalline cellulose (E 460) Hydroxypropylcellulose (E 463) Sodium laurilsulfate
Croatian: Sadržaj kapsule saharoza celuloza, mikrokristalična (E 460) hidroksipropilceluloza (E 463) natrijev laurilsulfat
English: The mean peak plasma concentration (Cmax) of aprepitant occurred at approximately 4 hours (tmax).
Croatian: Srednja vršna vrijednost koncentracije aprepitanta u plazmi (Cmax) se postiže nakon približno 4 sata (Tmax).
English: EMEND 40 mg hard capsules are supplied in the following pack sizes: - Aluminium blister containing one 40 mg capsule - 5 Aluminium blisters each containing one 40 mg capsule
Croatian: EMEND 40 mg tvrde kapsule dostupne su u sljedećim veličinama pakiranja: - aluminijski blister s jednom kapsulom od 40 mg - 5 aluminijskih blistera sa po jednom kapsulom od 40 mg
English: EMEND may have minor influence on the ability to ride a bicycle and use machines.
Croatian: EMEND malo utječe na sposobnost vožnje bicikla i rada sa strojevima.
English: Post-marketing events of neurotoxicity, a potential adverse reaction of ifosfamide, have been reported after aprepitant and ifosfamide co-administration.
Croatian: Nakon stavljanja u promet zabilježeni su slučajevi neurotoksičnosti, moguće nuspojave ifosfamida, nakon istodobne primjene aprepitanta i ifosfamida.
English: Additionally, no significant nausea in the overall period (0 to 120 hours post-chemotherapy) was evaluated as an exploratory endpoint, and in the acute and delayed phases as a post-hoc analysis.
Croatian: Osim toga, izostanak klinički značajne mučnine tijekom cijelog razdoblja (0 do 120 sati poslije kemoterapije) ocijenjen je kao eksploratorna mjera učinka te u post-hoc analizi akutne i kasnije faze.
English: Caution is advised when warfarin, acenocoumarol, tolbutamide, phenytoin or other active substances that are known to be metabolised by CYP2C9 are administered during this time period.
Croatian: Potreban je oprez kad se tijekom tog perioda primjenjuju varfarin, acenokumarol, tolbutamid, fenitoin ili druge djelatne tvari za koje se zna da se metaboliziraju putem CYP2C9.
English: Tell the doctor or pharmacist if you or the child are taking, have recently taken, or might take any other medicines.
Croatian: Obavijestite liječnika ili ljekarnika ako Vi ili dijete uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: What EMEND contains The active substance is aprepitant.
Croatian: Što EMEND sadrži Djelatna tvar je aprepitant.
English: During treatment with EMEND, CYP3A4 is inhibited.
Croatian: Tijekom liječenja lijekom EMEND, CYP3A4 je inhibiran.
English: Prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in children, toddlers and infants from the age of 6 months to less than 12 years.
Croatian: Prevencija mučnine i povraćanja povezanih s jako i umjereno emetogenom kemoterapijom raka u djece, male djece i dojenčadi u dobi od 6 mjeseci do manje od 12 godina.
English: During days 9 through 21 in this study, there was as much as a 64 % decrease in ethinyl estradiol trough concentrations and as much as a 60 % decrease in norethindrone trough concentrations.
Croatian: Od 9. do 21. dana ispitivanja zamijećeno je sniženje najniže koncentracije etinilestradiola od čak 64%, odnosno najniže koncentracije noretindrona od čak 60%.
English: What you need to know before you take or give EMEND
Croatian: Što morate znati prije nego počnete uzimati ili davati EMEND
English: Efficacy was based on the evaluation of the following primary and key secondary endpoints: No vomiting in the overall period (0 to 120 hours post-chemotherapy), evaluation of safety and tolerability of the aprepitant regimen for chemotherapy induced nausea and vomiting (CINV), and complete response (defined as no vomiting and no use of rescue therapy) in the overall period (0 to 120 hours post-chemotherapy).
Croatian: Ocjena djelotvornosti zasnivala se na temelju sljedećih primarnih i ključnih sekundarnih mjera ishoda: izostanak povraćanja tijekom cijelog razdoblja (0 do 120 sati nakon kemoterapije), procjena sigurnosti i podnošljivosti režima liječenja mučnine i povraćanja uzrokovanih kemoterapijom (CINV) aprepitantom te potpuni odgovor (definiran kao izostanak povraćanja i bez primjene dodatnih lijekova za olakšanje simptoma) tijekom cijelog razdoblja (0 do 120 sati nakon kemoterapije).
English: The Cmax was 10 % higher on Day 1 and 24 % higher on Day 5 in elderly relative to younger adults.
Croatian: Osim toga je u starijih osoba Cmax bio 10% viši 1. dan, odnosno 24% viši 5. dan, u odnosu na mlađe odrasle osobe.
English: Aprepitant regimen (N= 521)
Croatian: Režim s aprepitantom (N= 521)
English: The recommended dose of capsules of EMEND is 125 mg orally on Day 1 and 80 mg orally on Days 2 and 3.
Croatian: Preporučena doza EMEND kapsula je 125 mg peroralno 1. dana i 80 mg peroralno 2. i 3. dana.
English: EMEND should be used with caution in these patients (see section 5.2).
Croatian: U tih bolesnika EMEND treba primjenjivati uz oprez (vidjeti dio 5.2).
English: After treatment with EMEND, the doctor may ask you or the child to continue taking other medicines including a corticosteroid (such as dexamethasone) and a ‘5HT3 antagonist' (such as ondansetron) for preventing nausea and vomiting.
Croatian: Nakon liječenja lijekom EMEND, liječnik može preporučiti Vama ili djetetu da nastavite uzimati druge lijekove uključujući kortikosteroide (kao što je deksametazon) i „antagoniste 5-HT3“ (kao što je ondanzetron) za sprječavanje mučnine i povraćanja.
English: The dose of dexamethasone in chemotherapy induced nausea and vomiting clinical trials was chosen to account for active substance interactions (see section 4.2).
Croatian: U kliničkim je ispitivanjima sprječavanja mučnine i povraćanja izazvanih kemoterapijom doza deksametazona određena s obzirom na njegove interakcije s drugim djelatnim tvarima (vidjeti dio 4.2).
English: During treatment with EMEND, CYP3A4 is inhibited for up to 4 days.
Croatian: Tijekom liječenja EMEND kapsulama CYP3A4 je inhibiran u trajanju do 4 dana.
English: In a study with 2 mg midazolam orally co-administered with 200 mg aprepitant in the fed state (standard light breakfast), the AUC0-∞ of midazolam, a sensitive CYP3A4 substrate, was increased 3.2-fold on Day 1.
Croatian: U ispitivanju istodobne primjene peroralno primjenjenog midazolama u dozi od 2 mg i aprepitanta u dozi od 200 mg na pun želudac (standardni lagani doručak), AUC0-∞ midazolama, osjetljivog supstrata CYP3A4, povisio se 3,2 puta 1. dan liječenja.
English: Aprepitant regimen n/m (%)
Croatian: Režim liječenja aprepitantom n/m (%)
English: The AUC0-∞ of aprepitant following oral administration of 165 mg was equivalent to the AUC0-∞ of 150 mg fosaprepitant administered intravenously, while the Cmax was 2.4-fold lower.
Croatian: AUC0-∞ aprepitanta nakon peroralne doze od 165 mg bila je jednaka AUC0-∞ nakon intravenske doze fosaprepitanta u dozi od 150 mg, dok je srednja vršna vrijednost (Cmax ) snižena za 2,4 puta.
English: How to give EMEND
Croatian: Kako davati EMEND
English: Paediatric population: In a study using a powder for oral suspension formulation, a single dose of 40 mg aprepitant administered to adolescent patients (aged 12 through 17 years) resulted in a mean AUC0-48hr of 6 µg/mL with a mean peak plasma concentration (Cmax) of 0.5 µg/mL occurring at approximately 4 hours.
Croatian: Pedijatrijska populacija: U ispitivanju u kojem se lijek primjenjivao u obliku praška za oralnu suspenziju, jedna doza od 40 mg aprepitanta primijenjena adolescentnim bolesnicima (u dobi od 12 do 17 godina) rezultirala je srednjom vrijednosti AUC0-48hr od 6 µg/ml, uz srednju vrijednost vršnih koncentracija u plazmi (Cmax) od 0,5 µg/ml koja je nastupila nakon približno 4 sata.
English: During treatment for chemotherapy induced nausea and vomiting (CINV), the 3-day 125 mg/80 mg regimen of aprepitant is a moderate inhibitor of CYP3A4.
Croatian: Chemotherapy induced nausea and vomiting, CINV), trodnevni režim liječenja aprepitantom u dozi od 125 mg/80 mg uzrokuje umjerenu inhibiciju CYP3A4.
English: Oral administration of the capsule with an approximately 800 Kcal standard breakfast resulted in an up to 40 % increase in AUC of aprepitant.
Croatian: Peroralna primjena kapsule uz standardni doručak energetske vrijednosti oko 800 Kcal dovela je do povećanja AUC aprepitanta za najviše 40%.
English: Please talk to your doctor or pharmacist if you are taking any of the following medicines:
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate bilo koji od slijedećih lijekova:
English: The most common adverse reactions reported at a greater incidence in paediatric patients treated with the aprepitant regimen than with the control regimen while receiving emetogenic cancer chemotherapy were hiccups (3.3 % versus 0.0 %) and flushing (1.1 % versus 0.0 %).
Croatian: Najčešće nuspojave prijavljene s većom incidencijom u pedijatrijskih bolesnika liječenih aprepitantom nego kontrolnim režimom dok su primali emetogenu kemoterapiju zbog raka bile su štucavica (3,3 % naspram 0,0 %) i crvenilo uz osjećaj vrućine (1,1 % naspram 0,0 %).
English: OUTER PACKAGING - TRIFOLD PACK (CARTON) - 3-day treatment pack
Croatian: VANJSKO PAKIRANJE - TROSTRUKO PAKIRANJE (KUTIJA) - pakiranje za trodnevno liječenje
English: One patient in the Aprepitant regimen only had data in the acute phase and was excluded from the overall and delayed phase analyses.
Croatian: Za jednog bolesnika koji je primao režim s aprepitantom dostupni su bili podaci samo iz akutne faze te je isključen iz ukupne analize i analize kasnije faze liječenja.
English: The control regimen in adolescents aged 12 through 17 years (n=48) and children aged 6 months to less than 12 years (n=102) consisted of placebo for aprepitant on Days 1, 2 and 3 in combination with ondansetron on Day 1.
Croatian: Kontrolni režim liječenja u adolescenata u dobi od 12 do 17 godina (n=48) i djece u dobi od 6 mjeseci do manje od 12 godina (n=102) sastojao se od placeba za aprepitant 1., 2. i 3. dana u kombinaciji s ondanzetronom 1. dana.
English: Aprepitant (125 mg/80 mg) is a substrate, a moderate inhibitor, and an inducer of CYP3A4.
Croatian: Aprepitant (125 mg/ 80 mg) je supstrat, umjereni inhibitor, ali i induktor izoenzima CYP3A4.
English: If a doctor has told you that the child has an intolerance to some sugars, contact the doctor before giving this medicine to the child.
Croatian: Ako Vam je liječnik rekao da dijete ne podnosi neke šećere, savjetujte se s liječnikom prije nego što djetetu date ovaj lijek.
English: The aprepitant regimen for children aged 6 months to less than 12 years (n=105) consisted of EMEND powder for oral suspension 3.0 mg/kg (up to 125 mg) orally on Day 1 and 2.0 mg/kg (up to 80 mg) orally on Days 2 and 3 in combination with ondansetron on Day 1.
Croatian: Režim liječenja aprepitantom za djecu u dobi od 6 mjeseci do manje od 12 godina (n=105) sastojao se od EMEND praška za oralnu suspenziju u dozi od 3,0 mg/kg (do 125 mg) peroralno 1. dana i 2,0 mg/kg (do 80 mg) peroralno 2. i 3. dana u kombinaciji s ondanzetronom 1. dana.
English: EMEND is given for 3 days as part of a regimen that includes a corticosteroid and a 5-HT3 antagonist.
Croatian: EMEND se primjenjuje 3 dana u sklopu režima liječenja koji uključuje kortikosteroid i antagonist 5HT3.
English: everolimus - alfentanil, fentanyl - for pain - quinidine - for irregular heart beat - medicines for cancer - such as irinotecan, etoposide, vinorelbine, ifosfamide - medicines containing ‘ergot alkaloid derivatives' - such as ergotamine and diergotamine - for migraines - medicines that thin the blood - such as warfarin, acenocoumarol.
Croatian: everolimus - alfentanil, fentanil - za liječenje boli - kinidin - za liječenje nepravilnih otkucaja srca - lijekove za liječenje raka - kao što su irinotekan, etopozid, vinorelbin, ifosfamid - lijekove koji sadrže derivate ergot alkaloida - kao što su ergotamin i diergotamin - za liječenje migrene - lijekove za razrjeđivanje krvi - kao što su varfarin, acenokumarol.
English: % 95 % C.I.
Croatian: % 95% CI
English: 165 mg orally
Croatian: 165 mg peroralno
English: Patients with rare hereditary problems of fructose or galactose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrase-isomaltase insufficiency should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja fruktoze ili galaktoze, malapsorpcije glukoze-galaktoze, nedostatkom Lapp laktaze ili nedostatkom saharoze-izomaltaze ne smiju uzimati ovaj lijek.