FrancophonIA/ELRC3.0 huggingface dataset:
English: On 14 March 2007 the CVMP, having considered the new residue studies, concluded that it was not possible to set a withdrawal period for Suramox 15% LA and Stabox 15% LA, for either cattle or pig meat and offal and therefore recommended by consensus the suspension of the above marketing authorisations for the above-mentioned products.
Slovenian: Dne 14. marca 2007 je CVMP ob upoštevanju novih študij ostankov zaključil, da za zdravili Suramox 15 % LA in Stabox 15 % LA ni mogoče določiti karence ne za goveje meso in drobovino niti za meso in drobovino prašičev, zaradi česar je soglasno sprejel priporočilo, da se zgoraj omenjena dovoljenja za promet za zadevna zdravila začasno prekličejo.
English: During its June 2008 meeting the CVMP considered the new residue studies submitted with regard to Suramox 15% LA and concluded that withdrawal periods can now be set for both cattle and pigs for Suramox 15% LA and Stabox 15% LA.
Slovenian: CVMP je na svojem zasedanju v juniju 2008 preučil nove študije ostankov, predložene za zdravilo Suramox 15% LA, in zaključil, da je sedaj za zdravili Suramox 15% LA in Stabox 15 % LA možno določiti karenco tako za govedo kot tudi za prašiče.
English: On 13 September 2006 the CVMP considered the detailed grounds for the re-examination of the opinion and confirmed its previous opinion concluding that the marketing authorisations for Suramox 15% LA should be suspended.
Slovenian: Dne 13. septembra 2006 je CVMP obravnaval dostavljeno dokumentacijo in potrdil svoje prvotno mnenje, s katerim priporoča začasni preklic dovoljenja za promet za zdravilo Suramox 15 % LA.
English: Suramox 15% LA is an injectable suspension containing amoxicillin, which is a beta-lactam antibiotic belonging to the penicillin group.
Slovenian: Zdravilo Suramox 15 % LA je suspenzija za injiciranje, ki vsebuje amoksicilin, t.j.
English: During its May 2006 meeting, the CVMP, in light of the overall data submitted and the scientific discussion within the Committee, adopted by consensus an opinion recommending the suspension of the marketing authorisations for Suramox 15% LA and the Stabox 15% LA, for cattle and pigs.
Slovenian: Med svojim zasedanjem maja 2006 je CVMP na podlagi vseh posredovanih podatkov in znanstvene razprave soglasno sprejel mnenje in z njim priporočil začasni preklic dovoljenja za promet z zdraviloma Suramox 15 % LA in Stabox 15 % LA, namenjenima za zdravljenje goveda in prašičev.
English: There were three groups in this study.
Slovenian: V tej raziskavi so bile tri skupine.
English: There is no experience in children.
Slovenian: Izkušenj pri otrocih ni.
English: (95% confidence interval)
Slovenian: (95% interval zaupanja)
English: (Percent of Patients)
Slovenian: (odstotek bolnikov)
English: Infections may progress more rapidly and be more severe.
Slovenian: Okužbe lahko napredujejo hitreje in so hujše.
English: Patient's Name: _____________________ Doctor's Name: _____________________ Doctor's Phone: _____________________
Slovenian: Zdravnikovo ime: ____________________ Zdravnikov telefon: ____________________
English: Other opportunistic infections:
Slovenian: Druge oportunistične okužbe:
English: If this happens, do not use the syringe or vial.
Slovenian: Če se to zgodi, brizge ali viale ne uporabite.
English: Some patients were treated for up to 60 months duration.
Slovenian: Nekatere bolnike so zdravili do 60 mesecev.
English: In Study III, these improvements were maintained throughout 52 weeks.
Slovenian: V raziskavi III so se ta izboljšanja ohranila 52 tednov.
English: Quality of Life
Slovenian: Kvaliteta življenja
English: This includes tuberculosis.
Slovenian: To velja tudi za tuberkulozo.
English: Available data suggest that Trudexa does not worsen or cause strictures.
Slovenian: Razpoložljivi podatki kažejo, da Trudexa ne poslabša in ne povzroči striktur.
English: The injection is complete when the yellow indicator stops moving.
Slovenian: Injiciranje je končano, ko se rumeni kazalnik neha premikati.
English: It should be noted that in the majority of those reports, tuberculosis was extra-pulmonary, i.e. disseminated.
Slovenian: Opozoriti je treba, da je bila v večini teh primerov tuberkuloza zunajpljučna, tj. diseminirana.
English: An updated risk management plan should be provided as per the CHMP guideline on the risk management systems for medicinal products for human use.
Slovenian: Predložen bo posodobljen načrt upravljanja tveganja (“Risk Management Plan”) v skladu z navodili odbora CHMP “Guideline on the risk management systems for medicinal products for human use”.
English: Study III also had a primary endpoint of changes in quality of life.
Slovenian: Študija III je imela kot primarno končno točko tudi spremembe v kakovosti življenja.
English: Tuberculosis:
Slovenian: Tuberkuloza:
English: • protein in urine.
Slovenian: • beljakovine v urinu.
English: This may cause severe allergic reactions in patients sensitive to latex.
Slovenian: To lahko povzroči hude alergijske reakcije pri bolnikih, občutljivih za lateks.
English: Because the elimination of adalimumab may take up to five months, monitoring should be continued throughout this period.
Slovenian: Ker lahko eliminacija adalimumaba traja do pet mesecev, je treba bolnike ves ta čas nadzirati.
English: Significant response was first observed at Week 2 and maintained through 24 weeks (Table 8).
Slovenian: Značilen odziv so najprej opazili po 2 tednih in se je ohranil do 24. tedna (tabela 8).
English: What should I do before I give myself a subcutaneous injection of Trudexa?
Slovenian: Kaj moram narediti, preden si dam podkožno injekcijo Trudexe?
English: Serious infections:
Slovenian: Resne okužbe:
English: Table 1 Undesirable Effects in Clinical Studies
Slovenian: Tabela 1 Neželeni učinki v kliničnih študijah
English: For all of the above indications, available data suggest that the clinical response is usually achieved within 12 weeks of treatment.
Slovenian: Dosegljivi podatki za vse navedene indikacije kažejo, da se klinični odziv ponavadi pojavi v 12 tednih zdravljenja.
English: Puerto Rico 00617
Slovenian: Puerto Rico 00617 ZDA
English: The marketing authorisation holder should submit 6 monthly periodic safety update reports.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora predložiti periodično poročilo o varnosti zdravila vsakih 6 mesecev.
English: The MAH commits to performing the studies and additional pharmacovigilance activities detailed in the pharmacovigilance plan.
Slovenian: Imetnik dovoljenja za promet se zavezuje, da bo izvedel študije in dodatne farmakovigilančne aktivnosti, ki so opredeljene v farmakovigilančnem načrtu.
English: • You should be screened for tuberculosis.
Slovenian: • Opraviti morate presejalne preiskave za tuberkulozo.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 1 September 2003
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET 1. september 2003
English: Since Trudexa is given subcutaneously, food and drink should not affect Trudexa.
Slovenian: Ker se Trudexa uporablja subkutano, hrana in pijača naj ne bi vplivali na Trudexo.
English: Do NOT remove the grey stopper or aluminium ring around the top of the vial.
Slovenian: NE ODSTRANITE sivega zamaška ali aluminijastega obročka na vrhu viale.
English: Therefore, the combination of adalimumab and anakinra is not recommended.
Slovenian: Zato kombinacija adalimumaba in anakinre ni priporočena.
English: After cleaning, do not touch the stopper with your hands.
Slovenian: Po očiščenju se zamaška ne dotikajte več z rokami.
English: Trudexa in combination with methotrexate, is indicated for:
Slovenian: Trudexa je v kombinaciji z metotreksatom indicirana za:
English: Trudexa increases the risk of getting infections.
Slovenian: Trudexa zvečuje tveganje za okužbe.
English: • sensation of heart beating rapidly, high blood pressure;
Slovenian: • občutek hitrega bitja srca, visok krvni pritisk;
English: • allergic reactions;
Slovenian: • alergijske reakcije;
English: Monoclonal antibodies are proteins that recognise and bind to other unique proteins.
Slovenian: Monoklonska protitelesa so beljakovine, ki prepoznajo druge specifične beljakovine in se nanje vežejo.
English: Patients who have a known sensitivity to latex should be advised to avoid touching the inner shield.
Slovenian: Bolnikom z znano občutljivostjo za lateks je treba naročiti, da se ne smejo dotikati notranjega ščitnika.
English: There are two caps - one is grey and labelled ‘1' and the other is plum and labelled ‘2'.
Slovenian: Nameščena ima dva pokrovčka - eden je siv in označen z '1', drugi pa temnomoder in označen z '2'.
English: Tell your doctor immediately if you notice any of the following:
Slovenian: Svojemu zdravniku takoj povejte, če opazite kaj od naslednjega:
English: Using Trudexa with food and drink
Slovenian: Uporaba zdravila Trudexa skupaj s hrano in pijačo
English: • Show this card to any doctor involved in your treatment.
Slovenian: • To izkaznico pokažite vsakemu zdravniku, ki vas zdravi.
English: Concomitant stable doses of aminosalicylates, corticosteroids, and/or immunomodulatory agents were permitted and 79% of patients continued to receive at least one of these medications.
Slovenian: Dovoljena je bila sočasna uporaba stabilnih odmerkov aminosalicilatov, kortikosteroidov in/ali imunomodulacijskih zdravil; 79% bolnikov je še naprej prejemalo vsaj eno od takšnih zdravil.
English: If you use more Trudexa than you should:
Slovenian: Če ste uporabili večji odmerek Trudexe, kot bi smeli
English: • In some patients the body may fail to produce enough of the blood cells that help your body fight infections or help you to stop bleeding.
Slovenian: • Pri nekaterih bolnikih telo ne ustvari dovolj krvnih celic, ki pomagajo pri premagovanju okužbe ali ustavitvi krvavitve.
English: In addition, ACR response rates were maintained in the majority of patients followed in the open-label extension phase to week 104.
Slovenian: Poleg tega se je delež odziva po ACR ohranil pri večini bolnikov, ki so jih med odprto nadaljevalno fazo spremljali do 104. tedna.
English: Trudexa was studied in 5293 patients in controlled and open label trials for up to 60 months.
Slovenian: Trudexo so raziskali pri 5293 bolnikih v kontroliranih in odprtih preskušanjih, ki so trajala do 60 mesecev.
English: • Keep this card with you for 5 months after the last Trudexa dose, since side effects may occur a long time after your last dose of Trudexa.
Slovenian: • To izkaznico imejte pri sebi še 5 mesecev po zadnjem odmerku Trudexe, kajti neželeni učinki se lahko pojavijo še dolgo časa po zadnjem odmerku tega zdravila.
English: The effects of Trudexa in pregnant women are not known and so the use of Trudexa in pregnant women is not recommended.
Slovenian: Vplivi Trudexe pri nosečnicah niso znani, zato uporaba tega zdravila pri nosečih ženskah ni priporočljiva.
English: Maintenance of clinical remission was evaluated in CHARM.
Slovenian: Vzdrževanje klinične remisije je ocenjevala študija CHARM.
English: • anxiety, depression, feeling sleepy and difficulty sleeping;
Slovenian: • tesnobnost, depresija, zaspanost in težave s spanjem;
English: Hepatitis B Reactivation
Slovenian: Reaktivacija hepatitisa B
English: It is a medicine that decreases the inflammation process of these diseases.
Slovenian: Je zdravilo, ki ublaži vnetno dogajanje pri teh boleznih.
English: • If you have a severe infection, including active tuberculosis (see “Take special care with Trudexa”).
Slovenian: • če imate hudo okužbo, vključno z aktivno tuberkulozo (glejte "Bodite posebno pozorni pri uporabi Trudexe").
English: In all studies (I-VII), patients with raised ALT were asymptomatic and in most cases elevations were transient and resolved on continued treatment.
Slovenian: V vseh študijah (I-VII) so bili bolniki, ki so imeli zvišano ALT, asimptomatski; zvišanje je bilo večinoma prehodno in je med nadaljevanjem zdravljenja minilo.
English: Clinical remission results remained relatively constant irrespective of previous TNF antagonist exposure.
Slovenian: Rezultati glede klinične remisije so ostali razmeroma stalni, ne glede na prejšnje prejemanje antagonistov TNF.
English: ACR responses in Study VI were similar with and without concomitant methotrexate therapy.
Slovenian: Odzivi ACR v študiji VI so bili podobni ob sočasni terapiji z metotreksatom in brez nje.
English: • tuberculosis and other opportunistic infections (infections that occur when resistance to disease is lowered);
Slovenian: • tuberkuloza in druge oportunistične okužbe (okužbe, ki se pojavijo, kadar se zmanjša odpornost proti boleznim);
English: Then take your next dose as you would have on your originally scheduled day, had you not forgotten a dose.
Slovenian: Nato uporabite naslednji odmerek, kot bi ga uporabili po prvotnem urniku, če ne bi pozabili odmerka.
English: Improvement in quality of life was measured up to week 156 (36 months) and improvement was maintained through that time.
Slovenian: Izboljšanje kvalitete življenja se je ocenjevalo do 156. tedna (36. meseca).
English: • Pull the needle completely out of the vial.
Slovenian: • Iglo popolnoma potegnite iz viale.
English: It is important to tell your doctor if you have had or have a serious heart condition (see “Take special care with Trudexa”).
Slovenian: Pomembno je, da zdravniku poveste, če ste imeli ali imate kakšno resno bolezen srca (glejte "Bodite posebno pozorni pri uporabi Trudexe").
English: Store in a refrigerator (2°C - 8°C).
Slovenian: Shranjujte v hladilniku (2 °C - 8 °C) .
English: Trudexa is injected under the skin (subcutaneous use).
Slovenian: Trudexa se injicira pod kožo (subkutana uporaba).
English: Appropriate screening tests, i.e. tuberculin skin test and chest X-ray, should be performed in all patients (local recommendations may apply).
Slovenian: Pri vseh bolnikih je treba narediti ustrezne presejalne preiskave, tj. tuberkulinski kožni test in rentgensko slikanje prsnih organov (veljajo lahko lokalna priporočila).
English: The highest dose level evaluated has been multiple intravenous doses of 10 mg/kg.
Slovenian: Največji ocenjeni odmerek je obsegal večkratno intravensko aplikacijo 10 mg/kg.
English: Place the white end of the pre-filled pen at a right angle (90 degrees) to the skin, so that you can see the window.
Slovenian: Namestite beli konec napolnjenega injekcijskega peresnika pravokotno (90 stopinj) na kožo, tako da boste videli okence.
English: Induction of clinical remission (defined as CDAI < 150) was evaluated in two studies, CLASSIC I and GAIN.
Slovenian: Indukcijo klinične remisije (opredeljene kot CDAI < 150) so ocenili v dveh študijah, CLASSIC I in GAIN.
English: Before initiation of therapy with Trudexa, all patients must be evaluated for both active or inactive (latent) tuberculosis infection.
Slovenian: Pred začetkom zdravljenja s Trudexo je vse bolnike treba pregledati glede aktivne ali neaktivne (latentne) tuberkulozne okužbe.
English: • Severe rash, hives or other signs of allergic reaction;
Slovenian: • hud izpuščaj, koprivnico ali druge znake alergijske reakcije;
English: The average absolute bioavailability of adalimumab estimated from three studies following a single 40 mg subcutaneous dose was 64%.
Slovenian: Povprečna absolutna biološka uporabnost adalimumaba, ocenjena iz treh raziskav po enem 40 mg odmerku subkutano, je 64%.
English: • The Trudexa syringe should NEVER be reused.
Slovenian: • Brizge s Trudexo NIKDAR ne smete ponovno uporabiti.
English: It is not known whether adalimumab passes into breast milk.
Slovenian: Ni znano, ali se adalimumab izloča v materinem mleku.
English: If you forget to give yourself an injection, you should inject the next dose of Trudexa as soon as you remember.
Slovenian: Če si pozabite dati injekcijo, si morate naslednji odmerek Trudexe injicirati, čim se spomnite.
English: Trudexa has not been studied in these patient populations.
Slovenian: Trudexa pri teh populacijah bolnikov še ni bila preskušena.
English: Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 1-2 X 10-10 M).
Slovenian: Adalimumab modulira tudi biološke odzive, ki jih sproži ali uravnava TNF, vključno s spremembami koncentracije adhezijskih molekul, odgovornih za migracijo levkocitov (ELAM-1, VCAM-1 in ICAM-1 z IK50 1-2 x 10-10 M).
English: If you take Trudexa your risk may increase.
Slovenian: Če jemljete Trudexo, se ta verjetnost poveča.
English: This evaluation should include a detailed medical history with a personal history of tuberculosis or possible previous exposure to patients with active tuberculosis and previous and/or current immunosuppressive therapy.
Slovenian: Pregled mora obsegati podrobno zdravstveno anamnezo z osebno anamnezo tuberkuloze ali morebitnih predhodnih stikov z bolniki z aktivno tuberkulozo ter predhodnega in/ali trenutnega imunosupresivnega zdravljenja.
English: Thus additional caution should be exercised in considering Trudexa treatment of these patients (see section 4.8).
Slovenian: Torej je potrebna dodatna previdnost, kadar razmišljamo o zdravljenju s Trudexo pri teh bolnikih (glejte poglavje 4.8).
English: • Feeling weak or tired;
Slovenian: • občutek šibkosti ali utrujenosti;
English: If you accidentally inject Trudexa more frequently than told to by your doctor, you should call your doctor and tell him/her that you have taken more.
Slovenian: Če pomotoma injicirate Trudexo pogosteje, kot vam je naročil zdravnik, se morate posvetovati z njim in mu povedati, da ste uporabili večji odmerek.
English: Adalimumab concentrations in the synovial fluid from several rheumatoid arthritis patients ranged from 31-96% of those in serum.
Slovenian: Koncentracije adalimumaba v sinovijski tekočini več bolnikov z revmatoidnim artritisom so bile od 31 do 96% tistih v serumu.
English: After doses of 0.5 mg/kg (~40 mg), clearances ranged from 11 to 15 ml/hour, the distribution volume (Vss) ranged from 5 to 6 litres and the mean terminal phase halflife was approximately two weeks.
Slovenian: Po odmerkih 0,5 mg/kg (~40 mg) je bil očistek od 11 do 15 ml/uro, volumen distribucije (Vss) od 5 do 6 litrov in povprečni razpolovni čas terminalne faze približno dva tedna.
English: NA NA 9.5% 41.5%
Slovenian: NP 9,5% 41,5%
English: Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
Slovenian: Adalimumab se specifično veže na TNF in nevtralizira njegovo biološko delovanje, ker zavre njegovo interakcijo z receptorji p55 in p75 za TNF na površini celic.
English: Of those in clinical response at week 4, 48% had been previously exposed to other anti-TNF therapy.
Slovenian: Od tistih, ki so imeli 4. teden klinični odziv, jih je 48% predhodno dobilo drugo terapijo proti TNF.
English: • Use a new alcohol pad to clean the grey stopper on the vial.
Slovenian: • Uporabite nov alkoholni zloženec in z njim očistite sivi zamašek viale.
English: Similar trends (not all statistically significant) were seen in the smaller randomised, double − blind, placebo controlled study (IX) of 82 adult patients with active ankylosing spondylitis.
Slovenian: Podobni trendi (ki pa niso bili vsi statistično značilni) so bili opazni v manjši, randomizirani, dvojno slepi, s placebom kontrolirani študiji (IX) pri 82 odraslih bolnikih z aktivnim ankilozirajočim spondilitisom.
English: If your doctor determines that methotrexate is inappropriate, Trudexa can be given alone.
Slovenian: Če vaš zdravnik ugotovi, da metotreksat ni primeren, lahko Trudexo dobivate samo.
English: • Only use each pre-filled pen for one injection.
Slovenian: • Vsak napolnjeni injekcijski peresnik uporabite le za eno injiciranje.
English: The primary endpoint in Study V was the percent of patients who achieved an ACR 50 response at week 52.
Slovenian: Primarna končna točka študije V je bil odstotek bolnikov, ki so do 52. tedna dosegli odziv ACR 50.
English: • Advise your doctor if you are a carrier of the hepatitis B virus (HBV), if you have active HBV or if you think you might be at risk of contracting HBV. Trudexa can cause reactivation of
Slovenian: • Zdravniku morate povedati, če ste nosilec virusa hepatitisa B (HBV), če imate aktiven HBV ali če mislite, da bi se lahko nalezli HBV. Trudexa lahko pri nosilcih HBV povzroči reaktivacijo tega virusa.
English: PATIENT ALERT CARD TEXT (NOT INCLUDED IN PACK OR AS PART OF THE PACKAGE LEAFLET)
Slovenian: BESEDILO BOLNIKOVE OPOZORILNE IZKAZNICE (ni priložena pakiranju ali navodiliu za uporabo)
English: Side effects may occur at least up to 5 months after the last treatment.
Slovenian: Neželeni učinki se lahko pojavijo vsaj še 5 mesecev po zadnjem odmerku.
English: The efficacy and safety of Trudexa for the treatment of rheumatoid arthritis were assessed in five randomised, double-blind and well-controlled studies.
Slovenian: Učinkovitost in varnost Trudexe za zdravljenje revmatoidnega artritisa so ocenili v petih randomiziranih, dvojno slepih in dobro kontroliranih študijah.
English: Pull the plum safety cap (labelled ‘2') straight off to expose the plum coloured activation button at the top.
Slovenian: Snemite temnomodri varnostni pokrovček (označen z '2') naravnost dol, da se bo pokazal temnomodri sprožilni gumb na vrhu.
English: Please record the dates of the last screening for tuberculosis below: Tuberculin test: _______________ Chest X-ray:
Slovenian: Spodaj zabeležite datume zadnjih presejalnih preiskav za tuberkulozo: Tuberkulinski test: Rentgenogram prsnih organov: ____________
English: In CHARM, at week 4, 58% (499/854) of patients were in clinical response and were assessed in the primary analysis.
Slovenian: V študiji CHARM je imelo 4. teden klinični odziv 58% (499/854) bolnikov; ti so bili ocenjeni v primarni analizi.
English: If you have ankylosing spondylitis you will first be given other medicines.
Slovenian: Če imate ankilozirajoči spondilitis, boste najprej dobili druga zdravila.
English: Study VII
Slovenian: Študija VII
English: Check that the needle is below the surface of the solution.
Slovenian: Preverite, da je igla pod površino raztopine.
English: THE MARKETING AUTHORISATION HOLDER Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2).
Slovenian: Izdaja zdravila je le pod omejenimi pogoji in na recept (glejte Dodatek I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
English: Depending on your response, your doctor may increase the dose to 40 mg every week.
Slovenian: Odvisno od vašega odziva lahko zdravnik poveča odmerek na 40 mg vsak drugi teden.
English: WHAT TRUDEXA IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO TRUDEXA IN ZA KAJ GA UPORABLJAMO
English: In Study III, improvement in physical function was maintained through week 260 (60 months) of open-label treatment.
Slovenian: V študiji III se je izboljšanje telesne funkcije ohranilo vseskozi do 206. tedna (60. meseca) odprte faze zdravljenja.
English: • As cases of tuberculosis have been reported in patients treated with Trudexa, your doctor will check you for signs and symptoms of tuberculosis before starting Trudexa.
Slovenian: • Ker so bili pri bolnikih, zdravljenih s Trudexo, opisani primeri tuberkuloze, vas bo zdravnik pred začetkom zdravljenja s Trudexo preiskal glede znakov in simptomov tuberkuloze.
English: Treatment with Trudexa should not be initiated in patients with active infections including chronic or localized infections until infections are controlled.
Slovenian: Zdravljenja s Trudexo se ne sme začeti pri bolnikih z aktivnimi okužbami, vključno s kroničnimi ali lokaliziranimi, dokler te niso obvladane.
English: Table 8 - Efficacy Responses in Placebo-Controlled AS Study - Study VIII Reduction of Signs and Symptoms
Slovenian: Tabela 8 - Odzivi učinkovitosti v študiji AS, kontrolirani s placebom - študija VIII Zmanjšanje znakov in simptomov