FrancophonIA/ELRC3.0 huggingface dataset:
English: However, the incidences of decreases in serum calcium to < 8.0 mg/dl (2.0 mmol/l) and serum phosphate to  2.0 mg/dl (0.65 mmol/l) were similar in both treatment groups.
Danish: Imidlertid var incidensen af fald i serumcalcium til < 8,0 mg/dl (2,0 mmol/l) og i serumphosphat til ≤ 2,0 mg/dl (0,65 mmol/l) ens i begge behandlingsgrupper.
English: It is very important that the full dosing instructions are provided to, and are understood by the patient (see section 4.2).
Danish: Det er meget vigtigt, at patienterne modtager, og forstår, fuldstændig information om dosering (se pkt.
English: Alendronate prevents the loss of bone that occurs in women after they have been through the menopause, and helps to rebuild bone.
Danish: Alendronat hindrer det knogletab, der opstår hos kvinder efter overgangsalderen og bidrager til at genopbygge knoglemassen.
English: • allergic reactions such as hives; swelling of the face, lips, tongue and/or throat, possibly causing difficulty breathing or swallowing; severe skin reactions.
Danish: • Allergiske reaktioner som nældefeber; hævelse af ansigt, læber, tunge og/eller svælg, som muligvis kan medføre vejrtræknings- og synkebesvær; svære hudreaktioner.
English: The mean half-life of vitamin D3 in the serum following an oral dose of VANTAVO (70 mg/2800 IU) is approximately 24 hours.
Danish: Gennemsnitlig halveringstid for D3-vitamin i serum efter oral dosis VANTAVO (70 mg/2.800 IE) er ca. 24 timer.
English: Also contains: lactose and sucrose.
Danish: Indeholder også: Lactose og saccharose.
English: • you suffer from kidney problems,
Danish: • Du har nyreproblemer,
English: • tiredness; swelling in the hands or legs.
Danish: • Træthed, hævede hænder eller ben.
English: • blurred vision; pain or redness in the eye,
Danish: • Sløret syn, smerte eller rødmen i øjet.
English: Rare oesophageal stricture*, oropharyngeal ulceration*, upper gastrointestinal PUBs (perforation, ulcers, bleeding)
Danish: Øsofagusstriktur*, oropharyngeal ulceration*, øvre gastrointestinale PUB'er (perforation, ulcera, blødning)
English: VANTAVO is a tablet containing the two active substances, alendronic acid (commonly called alendronate) and colecalciferol known as vitamin D3.
Danish: VANTAVO er en tablet, der indeholder to aktive stoffer, alendronsyre (kaldes normalt alendronat) og cholecalciferol, kendt som D3-vitamin.
English: Do not take VANTAVO
Danish: Tag ikke VANTAVO
English: Vitamin D3 is rapidly metabolized by hydroxylation in the liver to 25-hydroxyvitamin D3, and subsequently metabolized in the kidney to 1,25-dihydroxyvitamin D3, which represents the biologically active form.
Danish: D3-vitamin metaboliseres hurtigt ved hydroxylering i leveren til 25-hydroxyvitamin D3 og metaboliseres efterfølgende i nyrerne til 1,25-dihydroxyvitamin D3, som repræsenterer den biologisk aktive form.
English: The mean increases from baseline in lumbar spine BMD at one year were 5.1 % (95 % CI: 4.8, 5.4 %) in the 70 mg once-weekly group and 5.4 % (95 % CI: 5.0, 5.8 %) in the 10 mg daily group.
Danish: Den gennemsnitlige stigning i BMD i columna lumbalis fra baseline til efter et år var 5,1 % (95 % KI: 4,8, 5,4 %) i den gruppe, der fik 70 mg ugentligt, og 5,4 % (95 % KI: 5,0, 5,8 %) i den gruppe, der fik 10 mg dagligt.
English: Bone, joint, and/or muscle pain has been reported in patients taking bisphosphonates.
Danish: Knogle-, led- og/eller muskelsmerter er rapporteret hos patienter, der tager bisphosphonater.
English: If you stop taking VANTAVO
Danish: Hvis du holder op med at tage VANTAVO
English: Physicians should therefore be alert to any signs or symptoms signalling a possible oesophageal reaction and patients should be instructed to discontinue alendronate and seek medical attention if they develop symptoms of oesophageal irritation such as dysphagia, pain on swallowing or retrosternal pain or new or worsening heartburn (see section 4.8).
Danish: Lægen skal derfor være opmærksom på alle tegn og symptomer, der kan indikere mulige øsofageale reaktioner, og patienterne skal instrueres om at seponere behandlingen med alendronat og søge læge, hvis de udvikler symptomer på øsofageal irritation, såsom dysphagi, synkesmerter, retrosternale smerter eller ny/forværret halsbrand (se pkt.
English: 4) Do not take VANTAVO at bedtime or before getting up for the day.
Danish: Tag ikke VANTAVO ved sengetid, eller før du står op.
English: Always take VANTAVO exactly as your doctor or pharmacist has told you.
Danish: Tag altid VANTAVO nøjagtigt efter lægens eller apotekspersonalets anvisning.
English: Non-clinical studies with the combination of alendronate and colecalciferol have not been conducted.
Danish: Der er ikke udført non-kliniske studier med kombination af alendronat og cholecalciferol.
English: Tablet
Danish: Tabletter.
English: The therapeutic equivalence of alendronate once weekly 70 mg (n=519) and alendronate 10 mg daily (n=370) was demonstrated in a one-year multicentre study of post-menopausal women with osteoporosis.
Danish: Den terapeutiske ækvivalens for alendronat 70 mg en gang ugentligt (n=519) og alendronat 10 mg dagligt (n=370) blev påvist i en 1-årig multicenterundersøgelse med postmenopausale kvinder med osteoporose.
English: Because there is a potential for worsening of the underlying disease, caution should be used when alendronate is given to patients with active upper gastrointestinal problems, such as dysphagia, oesophageal disease, gastritis, duodenitis, ulcers, or with a recent history (within the previous year) of major gastrointestinal disease such as peptic ulcer, or active gastrointestinal bleeding, or surgery of the upper gastrointestinal tract other than pyloroplasty (see section 4.3).
Danish: På grund af risiko for forværring af den tilgrundliggende sygdom, skal der udvises forsigtighed, når alendronat gives til patienter med aktive, øvre gastrointestinale problemer, såsom dysphagi, øsofagussygdom, gastritis, duodenitis, ulcera eller alvorlig gastrointestinal sygdom, såsom peptisk ulcus (inden for det seneste år), aktiv gastrointestinal blødning, eller til patienter, der har fået foretaget kirurgiske indgreb i øvre gastrointestinalkanal ud over pyloroplastik (se pkt.
English: Osteonecrosis of the jaw has also been reported in patients with osteoporosis receiving oral bisphosphonates.
Danish: Kæbeosteonekrose er også rapporteret hos patienter med osteoporose, der får orale bisphosphonater.
English: Vitamin D3 is converted to 25-hydroxyvitamin D3 in the liver, and stored until needed.
Danish: D3-vitamin omdannes til 25-hydroxyvitamin D3 i leveren og lagres indtil der er brug for det.
English: Patients should be instructed that if they miss a dose of VANTAVO they should take one tablet on the morning after they remember.
Danish: Patienterne bør informeres om, at hvis de glemmer at tage en VANTAVO tablet, skal de tage den morgenen efter, de er kommet i tanke herom.
English: At the menopause, the ovaries stop producing the female hormone, oestrogen, which helps to keep a woman's skeleton healthy.
Danish: Når menstruationerne ophører, holder æggestokkene op med at producere det kvindelige kønshormon østrogen, som medvirker til at holde kvindens knogler sunde.
English: • talk to your doctor if you have ear pain, discharge from the ear, and/or an ear infection.
Danish: • Sig det til lægen, hvis du får øresmerter, udflåd fra øret og/eller betændelse i øret.
English: 2031 BN, Haarlem, Netherlands
Danish: 2031 BN, Haarlem, Holland
English: VANTAVO contains lactose and sucrose.
Danish: VANTAVO indeholder lactose og saccharose.
English: Marketing Authorisation Holder and Manufacturer Merck Sharp & Dohme B.V.
Danish: Indehaver af markedsføringstilladelsen og fremstiller Merck Sharp & Dohme B.V.
English: • stomach or peptic ulcers (sometimes severe or with bleeding),
Danish: • Mavesår eller sår i mave- og tarmkanalen (nogle gange alvorlige eller med blødning).
English: PARTICULARS TO APPEAR WITHIN THE OUTER PACKAGING (CARTON)
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE (KARTON)
English: These are usually small and asymptomatic.
Danish: Nedgangen er som regel lille og ikke symptomatisk.
English: - Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Danish: - Overfølsomhed over for de aktive stoffer eller over for et eller flere af hjælpestofferne anført i pkt.
English: Do not crush or chew the tablet or allow it to dissolve in your mouth because of the possibility of mouth ulceration.
Danish: Du må ikke knuse eller tygge tabletten eller lade den blive opløst i munden på grund af risikoen for sår i munden.
English: • rash; redness of the skin,
Danish: • Udslæt, rødmen af hud.
English: What VANTAVO contains
Danish: VANTAVO indeholder:
English: Alendronate
Danish: Alendronat
English: Vitamin D3 is rapidly distributed mostly to the liver where it undergoes metabolism to 25-hydroxyvitamin D3, the major storage form.
Danish: D3-vitamin fordeles hurtigt til hovedsageligt leveren, hvor det metaboliseres til 25-hydroxyvitamin D3, den væsentligste oplagringsform.
English: In healthy subjects, oral prednisone (20 mg three times daily for five days) did not produce a clinically meaningful change in oral bioavailability of alendronate (a mean increase ranging from 20 % to 44 %).
Danish: Hos raske forsøgspersoner ændrer peroral prednison (20 mg, 3 gange dagligt i 5 dage) ikke alendronats perorale biotilgængelighed i signifikant grad (gennemsnitlig stigning fra 20-44 %).
English: Every week, take one VANTAVO tablet on your chosen day.
Danish: Tag én VANTAVO tablet hver uge på den valgte ugedag.
English: Croscarmellose sodium Sucrose
Danish: Croscarmellosenatrium Saccharose
English: There is important additional information about how to take VANTAVO in the package leaflet.
Danish: Der er yderligere vigtige informationer om, hvordan du skal tage VANTAVO i indlægssedlen.
English: If you forget to take VANTAVO
Danish: Hvis du har glemt at tage VANTAVO
English: Exercise
Danish: Motion
English: The other ingredients are microcrystalline cellulose (E460), lactose anhydrous (see section 2), medium chain triglycerides, gelatin, croscarmellose sodium, sucrose (see section 2), colloidal silicon dioxide, magnesium stearate (E572), butyl hydroxytoluene (E321), modified starch (maize), and sodium aluminium silicate (E554).
Danish: Øvrige indholdsstoffer: Mikrokrystallinsk cellulose (E460); lactose, vandfri (se punkt 2); triglycerider middelkædelængde; gelatine; croscarmellosenatrium; saccharose (se punkt 2); silica, kolloid vandfri; magnesiumstearat (E572); butyl hydroxytoluen (E321); modificeret majsstivelse og natriumaluminiumsilicat (E554).
English: It is likely that food and beverages (including mineral water) will make VANTAVO less effective if taken at the same time.
Danish: Brug af VANTAVO sammen med mad og drikke Det er sandsynligt, at mad og drikke (også mineralvand) vil nedsætte virkningen af VANTAVO, hvis det indtages på samme tid.
English: †, peripheral oedema Uncommon transient symptoms as in an acute-phase response (myalgia, malaise and rarely, fever), typically in association with initiation of treatment
Danish: Ikke almindelig Forbigående symptomer som i en akut-fase respons (myalgi, utilpashed og sjældent feber), typisk i forbindelse med initiering af behandlingen
English: In the two-year extension of these studies BMD at the spine and trochanter continued to increase and BMD at the femoral neck and total body were maintained.
Danish: I den 2-årige forlængelse af disse undersøgelser sås fortsat stigning i BMD i columna spinalis og trochanter.
English: Take one VANTAVO tablet once a week.
Danish: Tag én VANTAVO tablet én gang ugentligt.
English: 6) After swallowing your VANTAVO tablet, wait at least 30 minutes before taking your first food, drink, or other medicine of the day, including antacids, calcium supplements and vitamins.
Danish: Når du har slugt VANTAVO tabletten, skal du vente mindst 30 minutter, før du indtager dagens første måltid, drikke eller anden medicin, også syreneutraliserende midler, kalktilskud og vitaminer.
English: Oesophageal reactions (sometimes severe and requiring hospitalisation), such as oesophagitis, oesophageal ulcers and oesophageal erosions, rarely followed by oesophageal stricture, have been reported in patients receiving alendronate.
Danish: Der er rapporteret om øsofageale reaktioner (nogle gange alvorlige og indlæggelseskrævende), såsom øsofagitis, øsofageale ulcera samt øsofaguserosioner, i sjældne tilfælde efterfulgt af øsofagusstriktur, hos patienter i behandling med alendronat.
English: There have been side effects (for example, blurred vision, dizziness and severe bone, muscle or joint pain) reported with VANTAVO that may affect your ability to drive or operate machinery (see section 4).
Danish: Der er set bivirkninger med VANTAVO (f.eks. sløret syn, svimmelhed og alvorlige knogle-, muskeleller ledsmerter), som kan påvirke evnen til at køre bil eller betjene maskiner (se punkt 4).
English: • pain in the mouth, and/or jaw, swelling or sores inside the mouth, numbness or a feeling of heaviness in the jaw, or loosening of a tooth.
Danish: • Smerter i munden og/eller kæben, hævelser eller sår inde i munden, følelsesløshed eller tyngdefornemmelse i kæben eller løse tænder.
English: • if you have certain problems with your gullet (oesophagus - the tube that connects your mouth with your stomach) such as narrowing or difficulty swallowing,
Danish: • hvis du har visse problemer med spiserøret (øsofagus - det rør der forbinder din mund med maven), såsom forsnævring eller synkebesvær,
English: In the initial efficacy studies, the mean BMD increases with alendronate 10 mg/day relative to placebo at three years were 8.8 %, 5.9 % and 7.8 % at the spine, femoral neck and trochanter, respectively.
Danish: I de initiale virkningsundersøgelser, efter 3 års behandling med alendronat 10 mg dagligt, var de gennemsnitlige stigninger i BMD på henholdsvis 8,8 %, 5,9 % og 7,8 % i columna spinalis, collum femoris og trochanter, sammenlignet med placebo.
English: • symptoms of low blood calcium levels including muscle cramps or spasms and/or tingling sensation in the fingers or around the mouth,
Danish: • Symptomer på for lavt indhold af kalk i blodet omfattende muskelkramper eller trækninger og/eller prikkende fornemmelse i fingrene eller omkring munden.
English: *See sections 4.2 and 4.4
Danish: 4.2 og 4.4
English: Colloidal silicon dioxide Magnesium stearate (E572) Butyl hydroxytoluene (E321) Modified starch (maize) Sodium aluminium silicate (E554)
Danish: Siliciumdioxid, kolloid Magnesiumstearat (E572) Butylhydroxytoluen (E321) Modificeret majsstivelse Natriumaluminiumsilicat (E554)
English: The possibility of osteonecrosis of the external auditory canal should be considered in patients receiving bisphosphonates who present with ear symptoms such as pain or discharge, or chronic ear infections.
Danish: Muligheden for osteonekrose af øregangen skal overvejes hos patienter, der får behandling med bisphosphonater, og som udviser øresymptomer såsom øresmerter eller udflåd fra øret eller kroniske infektioner i øret.
English: The mean maximal serum concentration (Cmax) of vitamin D3 was 12.2 ng/ml and the median time to maximal serum concentration (Tmax) was 10.6 hours.
Danish: Gennemsnitlig maksimal serumkoncentration (Cmax) for D3-vitamin var 12,2 ng/ml, og den gennemsnitlige tid til maksimal serumkoncentration (Tmax) var 10,6 timer.
English: Common headache, dizziness Uncommon dysgeusia
Danish: Ikke almindelig Dysgeusi
English: If taken at the same time, it is likely that food and beverages (including mineral water), calcium supplements, antacids, and some oral medicinal products will interfere with absorption of alendronate.
Danish: Ved samtidig administration kan mad og drikkevarer (inklusive mineralvand), calciumtilskud, antacida samt visse peroralt administrerede lægemidler påvirke absorptionen af alendronat.
English: The mean maximal serum concentration (Cmax) of vitamin D3 was 5.9 ng/ml, and the median time to maximal serum concentration (Tmax) was 12 hours.
Danish: Gennemsnitlig maksimal serumkoncentration (Cmax) for D3-vitamin var 5,9 ng/ml, og den gennemsnitlige tid til maksimal serumkoncentration (Tmax) var 12 timer.
English: Neopharmed Gentili S.p.A. Tel. + 39 02 89 13 21 regulatory@neogen.it
Danish: Tel. + 39 02 89 13 21 regulatory@neogen.it
English: The percentage of patients with vitamin D deficiency was 0.3 % in the Vitamin D3 2,800 group vs. zero in the Vitamin D3 5,600 group.
Danish: Procentdelen af patienter med D-vitaminmangel var 0,3 % i D3-vitamin 2.800 gruppen versus nul i D3-vitamin 5.600 gruppen.
English: • if you are allergic to alendronic acid, colecalciferol or any of the other ingredients of this medicine (listed in section 6),
Danish: • hvis du er allergisk over for alendronsyre, cholecalciferol eller et af de øvrige indholdsstoffer i
English: It is likely that calcium supplements, antacids, and some oral medicines will interfere with the absorption of VANTAVO if taken at the same time.
Danish: Det er sandsynligt, at kalktilskud, syreneutraliserende midler og nogle andre former for medicin, der tages gennem munden, vil påvirke kroppens optagelse af VANTAVO, hvis det tages samtidigt.
English: While no increased risk was observed in extensive clinical trials with alendronate, there have been rare (post-marketing) reports of gastric and duodenal ulcers, some of which were severe and with complications (see section 4.8).
Danish: Selvom der i omfattende kliniske undersøgelser ikke er observeret øget risiko for ulcus ventriculi og ulcus duodeni, har der (efter markedsføring) været sjældne rapporter herom, i nogle tilfælde var disse alvorlige og med komplikationer (se pkt.
English: MARKETING AUTHORISATION NUMBER(S)
Danish: MARKEDSFØRINGSTILLADELSESNUMRE
English: Patients received the lower strength (70 mg/2800 IU) of VANTAVO (n=350) or FOSAMAX (alendronate) 70 mg (n=332) once a week; additional vitamin D supplements were prohibited.
Danish: Patienterne fik den lavere styrke (70 mg/2.800 IE) af VANTAVO (n=350) eller FOSAMAX (alendronat) 70 mg (n=332) én gang ugentligt; yderligere Dvitamin tilskud var ikke tilladt.
English: Other beverages (including mineral water), food and some medicinal products are likely to reduce the absorption of alendronate (see section 4.5 and section 4.8).
Danish: Andre drikkevarer (inklusive mineralvand), mad samt visse lægemidler kan nedsætte absorptionen af alendronat (se pkt.
English: It reduces the risk of vertebral and hip fractures.
Danish: Det reducerer risikoen for vertebrale frakturer og hoftefrakturer.
English: The bioavailability of the 5,600 IU vitamin D3 in VANTAVO is similar to 5,600 IU vitamin D3 administered alone.
Danish: Biotilgængeligheden for 5.600 IE D3-vitamin i VANTAVO er lig med 5.600 IE D3-vitamin, administreret alene.
English: The active substances are alendronic acid and colecalciferol (vitamin D3).
Danish: Aktive stoffer: Alendronsyre og cholecalciferol (D3-vitamin).
English: As we get older our skin makes less vitamin D. Too little vitamin D may lead to bone loss and osteoporosis.
Danish: Efterhånden som vi bliver ældre, danner vores hud mindre D-vitamin.
English: • nausea; vomiting,
Danish: • Kvalme, opkastning.
English: If you miss a dose, take only one VANTAVO tablet on the morning after you remember.
Danish: Hvis du glemmer en tablet, skal du blot tage en VANTAVO tablet om morgenen, efter du er kommet i tanke om det.
English: How can osteoporosis be treated?
Danish: Hvordan kan knogleskørhed behandles?
English: • Patients should only swallow VANTAVO whole.
Danish: • Patienten skal sluge VANTAVO tabletten hel.
English: Gastrointestinal disorders
Danish: Øvre gastrointestinale bivirkninger
English: Medicines for fits (seizures) (like phenytoin or phenobarbital) may decrease the effectiveness of vitamin D. Additional vitamin D supplements may be considered on an individual basis.
Danish: Medicin til krampeanfald (såsom phenytoin eller phenobarbital) kan nedsætte virkningen af D-vitamin.
English: • VANTAVO should not be taken at bedtime or before arising for the day.
Danish: • VANTAVO må ikke tages ved sengetid, eller før patienten er stået op om morgenen.
English: Other side effects include
Danish: Andre bivirkninger
English: There was a 48 % reduction (alendronate 3.2 % vs placebo 6.2 %) in the proportion of patients treated with alendronate experiencing one or more vertebral fractures relative to those treated with placebo.
Danish: Af patienter i behandling med alendronat oplevede 48 % færre en eller flere vertebrale frakturer (alendronat 3,2 % versus placebo 6,2 %) sammenlignet med patienter behandlet med placebo.
English: No additional adverse reactions have been identified for the combination of alendronate and colecalciferol.
Danish: Der er ikke identificeret nye bivirkninger af kombinationen alendronat og cholecalciferol.
English: No dose adjustment is necessary for patients with a creatinine clearance greater than 35 ml/min.
Danish: Dosisjustering er ikke nødvendig hos patienter med kreatinin-clearance >35 ml/min.
English: VANTAVO 70 mg 2800 IU
Danish: VANTAVO 70 mg 2800 IE
English: • black or tar-like stools,
Danish: • Sort eller tjærelignende afføring.
English: The alendronate component in the VANTAVO (70 mg/2800 IU) combination tablet and the VANTAVO (70 mg/5,600 IU) combination tablet is bioequivalent to the alendronate 70 mg tablet.
Danish: Alendronatkomponenten i VANTAVO (70 mg/2.800 IE) kombinationstabletten og VANTAVO (70 mg/5.600 IE) kombinationstabletten er bioækvivalent med alendronat i 70 mg tabletten.
English: In severe cases, deficiency results in secondary hyperparathyroidism, hypophosphataemia, proximal muscle weakness and osteomalacia, further increasing the risk of falls and fractures in osteoporotic individuals.
Danish: I svære tilfælde resulterer manglen i sekundær hyperparathyroidisme, hypophosphatæmi, proksimal muskelsvaghed og osteomalaci.
English: The effect of the lower dose of VANTAVO (alendronate 70 mg/vitamin D3 2800 IU) on vitamin D status was demonstrated in a 15-week, multinational study that enrolled 682 osteoporotic postmenopausal women (serum 25-hydroxyvitamin D at baseline: mean, 56 nmol/l [22.3 ng/ml]; range, 22.5-225 nmol/l [9-90 ng/ml]).
Danish: Effekten af den lave dosis af VANTAVO (alendronat 70 mg/D3-vitamin 2.800 IE) på D-vitamin status blev påvist i en 15 ugers multinational undersøgelse, der inkluderede 682 postmenopausale kvinder med osteoporose (serum 25-hydroxyvitamin D ved baseline: Gennemsnit, 56 nmol/l [22,3 ng/ml]; variationsbredde, 22,5-225 nmol/l [9-90 ng/ml]).
English: It reduces the risk of spine and hip fractures in women after menopause.
Danish: Det nedsætter risikoen for hoftebrud og brud på rygsøjlen hos kvinder efter overgangsalderen.
English: The percentage of patients with vitamin D insufficiency was 5.4 % in the Vitamin D3 2,800 group vs. 3.2 % in the Vitamin D3 5,600 group through the 24-week extension.
Danish: Procentdelen af patienter med D-vitaminmangel var 5,4 % i D3-vitamin 2.800 gruppen versus 3,2 % i D3-vitamin 5.600 gruppen gennem 24-ugers ekstensionsperioden.
English: The most commonly reported adverse reactions are upper gastrointestinal adverse reactions including abdominal pain, dyspepsia, oesophageal ulcer, dysphagia, abdominal distension and acid regurgitation
Danish: De hyppigst indberettede bivirkninger er øvre gastrointestinale bivirkninger, herunder abdominalsmerter, dyspepsi, øsofageal ulcus, dysfagi, abdominal udspiling og syreregurgitation
English: What you need to know before you take VANTAVO
Danish: Det skal du vide, før du begynder at tage VANTAVO
English: Osteonecrosis of the external auditory canal has been reported with bisphosphonates, mainly in association with long-term therapy.
Danish: Der er rapporteret osteonekrose af øregangen med bisphosphonater, hovedsageligt i forbindelse med langtidsbehandling.