FrancophonIA/ELRC3.0 huggingface dataset:
English: Imatinib Accord 400 mg film-coated tablets are brownish orange, oval shaped, biconvex, film-coated tablets, debossed on one side with ‘IM' and ‘T2' on either side of breakline and plain on the other side.
Icelandic: Imatinib Accord 400 mg filmuhúðaðar töflur eru brún-appelsínugular, sporöskjulaga, tvíkúptar, filmuhúðaðar töflur, ígreyptar á annarri hliðinni með ‘IM' og ‘T2' beggja megin við deilistrikið og sléttar hinu megin.
English: Based on the recovery of compound(s) after an oral 14C-labelled dose of imatinib, approximately 81%
Icelandic: Á grundvelli endurheimtra efnasambanda eftir inntöku 14C-merkts skammts af imatinibi til inntöku,
English: In newly diagnosed chronic phase CML grade 4neutropenia (ANC < 0.5x109/1) and thrombocytopenia (platelet count < 10x109/1) were observed in 3.6% and < 1% of patients, respectively.
Icelandic: 4 (ANC < 0,5 x 109/1) hjá 3,6% sjúklinga og blóðflagnafæð (blóðflagnafjöldi < 10 x 109/1) hjá < 1% sjúklinga.
English: Palmoplantar erythrodysesthesia syndrome*, lichenoid keratosis*, lichen planus*, toxic epidermal necrolysis*, drug rash with eosinophilia and systemic symptoms
Icelandic: Handa- og fótaheilkenni (palmoplantar erythrodysesthesia syndrome)*, hornlagsskæningur (lichenoid keratosis)*, flatskæningur*, eitrunardreplos húðþekju*, lyfjaútbrot ásamt rauðkyrningageri og altækum einkennum (DRESS) , sýndarporfyría*
English: One phase II, open label, multicentre clinical trial (study B2225) was conducted including 12 patients with DFSP treated with imatinib 800 mg daily.
Icelandic: Fram fór ein opin, fjölsetra, II. stigs klínísk rannsókn (rannsókn B2225) sem í tóku þátt 12 sjúklingar með DFSP, sem fengu meðferð með imatinibi 800 mg á sólarhring.
English: Major cytogenetic response, haematological response, molecular response (evaluation of minimal residual disease), time to accelerated phase or blast crisis and survival are main secondary endpoints.
Icelandic: Meiriháttar litningasvörun, blóðsvörun, sameindasvörun (mat á lágmarks sjúkdómshreytum ), tími að hröðunarfasa eða bráðafasa og lifun eru helstu aukaendapunktar.
English: Polyethylene glycol Iron oxide yellow (E172) Iron oxide red (E172)
Icelandic: Hýprómellósi 6 cps (E464) Talkúm (E553b) Pólýetýlen glýkól Járnoxíð, gult (E172) Járnoxíð, rautt (E172)
English: This is because Imatinib Accord could cause hepatitis B to become active again, which can be fatal in some cases.
Icelandic: Þetta er vegna þess að Imatinib Accord gæti endurvirkjað lifrarbólgu
English: How to take Imatinib Accord
Icelandic: Hvernig geyma á Imatinib Accord
English: Paediatric accelerated phase CML and blast crisis (starting dose 340 mg/m2)
Icelandic: Hröðunarfasi CML og bráðafasi, hjá börnum, (upphafsskammtur 340 mg/m²)
English: Imatinib Accord 100 mg tablets
Icelandic: Imatinib Accord 100 mg töflur
English: Imatinib Accord 400 mg tablets
Icelandic: Imatinib Accord 400 mg töflur
English: For CML, your doctor may prescribe a higher or lower dose depending on how you respond to the treatment.
Icelandic: Í samræmi við meðferðarsvörun er hugsanlegt að læknirinn ávísi stærri eða minni skammti við CML.
English: The primary efficacy variable was the rate of haematological response, reported as either complete haematological response, no evidence of leukaemia, or return to chronic phase CML using the same criteria as for the study in accelerated phase.
Icelandic: Fyrsta verkunarbreytan var hlutfall blóðsvörunar, sem annaðhvort var greint frá sem heildarblóðsvörun, engri vísbendingu um hvítblæði eða afturhvarfi í stöðugan fasa CML og var gengið út frá sömu forsendum og í rannsókninni á hröðunarfasa.
English: INFORMATION IN BRAILLE Imatinib Accord 100 mg
Icelandic: 16. UPPLÝSINGAR MEÐ BLINDRALETRI Imatinib Accord 100 mg
English: Silica colloidal, anhydrous Magnesium stearate
Icelandic: Kísilkvoða, vatnsfrí Magnesíumsterat
English: The required number of tablets should be placed in the appropriate volume of beverage (approximately 50 ml for a 100 mg tablet, and 200 ml for a 400 mg tablet) and stirred with a spoon.
Icelandic: 50 ml fyrir 100 mg töflu og 200 ml fyrir 400 mg töflu) og hræra með skeið.
English: Imatinib Accord will only be prescribed to you by a doctor with experience in medicines to treat blood cancers or solid tumours.
Icelandic: Einungis læknir með reynslu af lyfjum til meðferðar við blóðkrabbameinum eða æxlum mun ávísa Imatinib Accord.
English: Consolidation therapy DEX 10 mg/ m2oral, days 1-5; Vindesine 3 mg/ m2 i.v., day 1;
Icelandic: DEX 10 mg/m2 til inntöku, daga 1-5; Vindesin 3 mg/m2 i.v., dag 1;
English: Imatinib Accord 100 mg film-coated tablets are brownish orange, round biconvex, film-coated tablets, debossed on one side with ‘IM' and ‘T1' on either side of breakline and plain on the other side.
Icelandic: Lýsing á útliti Imatinib Accord og pakkningastærðir Imatinib Accord 100 mg filmuhúðaðar töflur eru brún-appelsínugular, kringlóttar, tvíkúptar, filmuhúðaðar töflur, ígreyptar á annarri hliðinni með ‘IM' og ‘T1' beggja megin við deilistrikið og sléttar hinu megin.
English: INFORMATION IN BRAILLE Imatinib Accord 400 mg
Icelandic: 16. UPPLÝSINGAR MEÐ BLINDRALETRI Imatinib Accord 400 mg
English: Tabulated list of adverse reactions
Icelandic: Meirihátta litningasvörun response
English: Methotrexate (5 g/m2 over 24 hours, IV): days 1 and 15 Leucovorin (75 mg/m2 at hour 36, IV; 15 mg/m2 IV or PO q6h x
Icelandic: Metótrexat (5 g/m2 á 24 klst., i.v.): dagar 1 og 15 Leucovorin (75 mg/m2 á 36. klst. i.v.; 15 mg/m2 i.v. eða til inntöku á 6 klst.
English: Patients should be tested for HBV infection before initiating treatment with Imatinib Accord.
Icelandic: B veirusýkingu áður en meðferð með Imatinib Accord er hafin.
English: Active substances that may have their plasma concentration altered by imatinib
Icelandic: Virk efni sem imatinib getur breytt plasmaþéttni fyrir
English: Table 3 Response in adult CML studies Study 0110 37-month data Chronic phase, IFN failure (n=532)
Icelandic: Upplýsingar eftir 37 mánuði Stöðugur fasi, IFN án árangurs (n=532)
English: Additionally Imatinib Accord 100 mg tablets are also available in perforated unit dose blister packs (PVC/PVdC/Alu) containing 30x1, 60x1, 90x1, 120x1 or 180x1 film-coated tablets.
Icelandic: Imatinib Accord 100 mg töflur einnig í rifgötuðum stakskammta þynnupakkningum (PVC/PVdC/ál) með 30x1, 60x1, 90x1, 120x1 eða 180x1 filmuhúðuðum töflum.
English: Patients with Renal impairment should be given the minimum starting dose.
Icelandic: Nota á minnsta upphafsskammt handa sjúklingum með skerta nýrnastarfsemi.
English: Each 400 mg film-coated tablet of Imatinib Accord contains 400 mg imatinib (as mesilate).
Icelandic: Hver 400 mg Imatinib Accord filmuhúðuð tafla inniheldur 400 mg af imatinibi (sem mesilat).
English: Each 100 mg film-coated tablet of Imatinib Accorcd ontains 100 mg imatinib (as mesilate).
Icelandic: Hver 100 mg Imatinib Accord filmuhúðuð tafla inniheldur 100 mg af imatinibi (sem mesilat).
English: If you take more Imatinib Accord than you should
Icelandic: Ef tekinn er stærri skammtur af Imatinib Accord en mælt er fyrir um
English: Brownish orange, round, biconvex, film-coated tablets, debossed on one side with ‘IM' and ‘T1' on either side of breakline and plain on the other side.
Icelandic: Brún-appelsínugular, kringlóttar, tvíkúptar, filmuhúðaðar töflur, ígreyptar á annarri hliðinni með ‘IM' og ‘T1' beggja megin við deilistrikið og sléttar hinu megin.
English: Additionally Imatinib Accord 100 mg tablets are also available in PVC/PVdC/Alu perforated unit dose blister in pack-sizes of 30x1, 60x1, 90x1, 120x1 or 180x1 film-coated tablets.
Icelandic: Imatinib Accord 100 mg töflur einnig í rifgötuðum stakskammta PVC/PVdC/álþynnum í pakkningastærðum með 30x1, 60x1, 90x1, 120x1 eða 180x1 filmuhúðuðum töflum.
English: Substances that are inducers of CYP3A4 activity (e.g. dexamethasone, phenytoin, carbamazepine, rifampicin, phenobarbital, fosphenytoin, primidone or Hypericum perforatum, also known as St. John's Wort) may significantly reduce exposure to imatinib, potentially increasing the risk of therapeutic failure.
Icelandic: Efni sem virkja CYP3A4 (t.d. dexametason, fenytoin, carbamazepin, rifampicin, fenobarbital, fosfenytoin, primidon eða Hypericum perforatum, einnig þekkt sem jóhannesarjurt [jónsmessurunni.
English: Three (3) patients with HES and CEL associated with PDGFR gene re-arrangements were reported in 3publications.
Icelandic: Í 3 birtum heimildum var greint var frá 3 sjúklingum með HES og CEL í tengslum við PDGFR endurröðun erfðavísa.
English: 6-10 days of cranial irradiation beginning on day 1 of Cycle 5.
Icelandic: (Gera skal hlé á 6-MP þá 6-10 sólarhringa sem geislun á höfuð stendur yfir, frá 1. degi 5. lotu.
English: CHR rate n (%) [95% CI]
Icelandic: Að hluta CyR n (%)
English: CPM (250 mg/m2/dose q12h x 4 doses, IV): days 3 and 4 PEG-ASP (2500 IUnits/m2, IM): day 4
Icelandic: DAUN (45 mg/m2/sólarhring í einum skammti [bolus], i.v.): dagar 1 og 2 CPM (250 mg/m2/skammt á 12 klst. fresti x 4 skammtar, i.v.): dagar 3 og 4 PEG-ASP (2500 a.einingar/m2, i.m.): dagur 4
English: MTX 12 mg intrathecal, day 1 Remission induction DEX 10 mg/ m2 oral, days 6-7, 13-16;
Icelandic: DEX 10 mg/m2 til inntöku, daga 6-7, 13-16;
English: (0.5 h), days 7, 8, 14, 15; CP 500 mg/ m2 i.v.
Icelandic: IDA 8 mg/m2 i.v. (0,5 klst.), daga 7, 8, 14, 15; CP 500 mg/m2 i.v.(1 klst.) dag 1;
English: bone pain10
Icelandic: Lota 5
English: You should take
Icelandic: Á ekki við
English: MTX 15 mg intrathecal, day1;
Icelandic: MTX 15 mg í mænuvökva, dag 1;
English: DEX 40 mg/day on days 1-4 and 11-14, alternated with MTX 1 g/ m2 i.v.
Icelandic: DEX 40 mg/sólarhring daga 1-4 og 11-14, til skiptis við MTX 1 g/m2 i.v. (24 klst.), dag 1, Ara-C 1 g/m2 i.v. (2 klst., með 12 klst. millibili), daga 2-3 (samtals 8 meðferðarlotur)
English: The recommended dose of Imatinib Accord is 100 mg/day for adult patients with HES/CEL.
Icelandic: Ráðlagður skammtur af Imatinib Accord er 100 mg/sólarhring handa fullorðnum sjúklingum með HES/CEL.
English: Methylprednisolone 40 mg intrathecal, day1
Icelandic: Metylprednisolon 40 mg í mænuvökva, dag 1
English: The recommended dosage of Imatinib Accord is 600 mg/day for adult patients in accelerated phase.
Icelandic: Ráðlagður skammtur af Imatib Accord er 600 mg/sólarhring fyrir fullorðna sjúklinga í hröðunarfasa.
English: Brownish orange, oval shaped, biconvex, film-coated tablets, debossed on one side with ‘IM' and ‘T2' on either side of breakline and plain on the other side.
Icelandic: Brún-appelsínugular, sporöskjulaga, tvíkúptar, filmuhúðaðar töflur, ígreyptar á annarri hliðinni með ‘IM' og ‘T2' beggja megin við deilistrikið og sléttar hinu megin.
English: SPECIAL STORAGE CONDITIONS For PVC/PVdC/Alu blisters Do not store above 30C.
Icelandic: SÉRSTÖK GEYMSLUSKILYRÐI Fyrir PVC/PVdC/álþynnupakkningar
English: Patients with Severe renal impairment should be treated with caution.
Icelandic: Gæta skal varúðar við meðferð sjúklinga með alvarlega skerta nýrnastarfsemi.
English: Using this approach, the estimated cumulative response rates for first-line treatment with Imatinib improved from 12 months of therapy to 84 months of therapy as follows: CHR from 96.4% to 98.4% and CCyR from 69.5% to 87.2%, respectively.
Icelandic: CHR fer úr 96,4% í 98,4% og CCyR fer úr 69,5% í 87,2%.
English: Imatinib Accord 100 mg film-coated tablets
Icelandic: Imatinib Accord 100 mg filmuhúðaðar töflur
English: Additionally Imatinib Accord 400 mg tablets are available in perforated unit dose blister packs (PVC/PVdC/Alu) containing 30x1, 60x1or 90x1 film-coated tablets.
Icelandic: Imatinib Accord 400 mg töflur í rifgötuðum stakskammta þynnupakkningum (PVC/PVdC/ál) með 30x1, 60x1 eða 90x1 filmuhúðuðum töflum.
English: Imatinib Accord 400 mg film-coated tablets
Icelandic: Imatinib Accord 400 mg filmuhúðaðar tablets
English: Mild
Icelandic: Frásog
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 100 mg imatinib (as mesilate)
Icelandic: VIRK(T) EFNI Hver filmuhúðuð tafla inniheldur 100 mg af imatinibi (sem mesilat)
English: MTX 1.5 g/ m2 i.v.
Icelandic: MTX 1,5 g/m2 i.v. (24 klst.), dag 1;
English: Active substances that may increase imatinib plasma concentrations
Icelandic: Virk efni sem geta aukið plasmaþéttni imatinibs:
English: One large, open-label, multicentre, international randomised phase III study has been conducted in patients with newly diagnosed Ph+ CML.In addition, children and adolescents have been treated in two phase I studies and one phase II study.
Icelandic: Að auki hafa börn og unglingar verið meðhöndluð í tveimur I. stigs rannsóknum og einni II stigs rannsókn.
English: Dose increases from 340 mg/m2 daily to 570 mg/m2 daily (not to exceed the total dose of 800 mg) may be considered in children and adolescents in the absence of severe adverse drug reaction and severe non-leukaemia-related neutropenia or thrombocytopenia in the following circumstances: disease progression (at any time); failure to achieve a satisfactory haematological response after at least 3 months of treatment; failure to achieve a cytogenetic response after 12 months of treatment; or loss of a previously achieved haematological and/or cytogenetic response.
Icelandic: Íhuga má aukningu skammta úr 340 mg/m² daglega í 570 mg/m² daglega (þó má ekki fara yfir heildarskammtinn 800 mg) hjá börnum og unglingum ef ekki koma fram alvarlegar aukaverkanir og ekki alvarleg daufkyrningafæð (neutropenia) eða blóðflagnafæð sem ekki tengjast hvítblæðinu, við eftirfarandi aðstæður:
English: Doxorubicine 50 mg/ m2 i.v.
Icelandic: Doxorubicin 50 mg/m2 i.v. (24 klst.), dag 4;
English: ANC < 1.0x109/l and/or platelets < 50 x 109/l
Icelandic: ANC < 1,0 x 109/l og/eða blóðflögur
English: If you are being treated for HES/CEL
Icelandic: Skammtar við HES/CEL
English: Additionally Imatinib Accord 400 mg tablets are available in PVC/PVdC/Alu perforated unit dose blister in pack-sizes of 30x1, 60x1 or 90x1 film-coated tablets.
Icelandic: Imatinib Accord 400 mg töflur í rifgötuðum stakskammta PVC/PVdC/álþynnum í pakkningastærðum með 30x1, 60x1 eða 90x1filmuhúðuðum töflum.
English: Some medicines can interfere with the effect of Imatinib Accord when taken together.
Icelandic: Við samhliða notkun geta sum lyf haft áhrif á verkun Imatinib Accord.
English: (3h), days1-4; Mitoxantrone 10 mg/m2 i.v.
Icelandic: Ara-C 1.000 mg/m2/12 klst. i.v.(3 klst.), daga 1-4; Mitoxantron 10 mg/m2 i.v. daga 3-5;
English: How much Imatinib Accord to take
Icelandic: Hve mikið á að nota af Imatinib Accord
English: ANC = absolute neutrophil count aoccurring after at least 1 month of treatment Special populations Hepatic insufficiency
Icelandic: akemur fyrir eftir að minnsta kosti 1 mánaðar meðferð.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 400 mg imatinib (as mesilate)
Icelandic: VIRK(T) EFNI Hver filmuhúðuð tafla inniheldur 400 mg af imatinibi (sem mesilat).
English: Imatinib Accord 100 mg film-coated tablets Imatinib Accord 400 mg film-coated tablets imatinib
Icelandic: Imatinib Accord 100 mg filmuhúðaðar töflur imatinib
English: Very common Weight increased Common
Icelandic: Meltingarfæri Mjög algengar
English: Ara-C 2x 2 g/ m2 i.v.
Icelandic: Ara-C 2 x 2 g/m2 i.v. (3 klst., með 12 klst. millibili), dag 5
English: Overall, in patients receiving first-line Imatinib, the average daily dose delivered was 406 ± 76 mg.
Icelandic: Á heildina litið var sólarhringsskammtur að meðaltali 406 ± 76 mg hjá sjúklingum sem fengu Imatinib sem fyrstu meðferð.
English: Table 1 Tabulated summary of adverse reactions Infections and infestations Uncommon
Icelandic: Tafla 1 Tafla með samantekt á aukaverkunum
English: You will also have blood tests and be weighed regularly.
Icelandic: Einnig verður fylgst reglulega með blóðhag og þyngd þann tíma sem Imatinib Accord er notað.
English: Hepatitis B reactivation*
Icelandic: Endurkoma (endurvirkjun) lifrarbólgu
English: (1 h), days 1-5; VM26 60 mg/ m2 i.v.
Icelandic: Ara-C 75 mg/m2 i.v. (1 klst.), daga 1-5; VM26 60 mg/m2 i.v. (1 klst.), daga 1-5
English: 4 tablets of 100 mg or 1 tablet of 400 mg in the morning and 4 tablets of 100 mg or 1 tablet of 400 mg in the evening.
Icelandic: 400 mg, en þá eru teknar 4 töflur með 100 mg eða 1 tafla með 400 mg einu sinni á sólarhring
English: Avascular necrosis/hip necrosis*, growth retardation in children and adolescents* Renal and urinary disorders
Icelandic: Blóðþurrðardrep/drep í mjöðm*, vaxtarskerðing hjá börnum og unglingum
English: DEX 10 mg/ m2 oral, days 1-5; CP 200 mg/ m2 i.v., days 3-5; MTX 15mg intrathecal, day 1
Icelandic: DEX 10 mg/m2 til inntöku, daga 1-5; CP 200 mg/m2 i.v., daga 3-5;
English: Colitis, ileus, inflammatory bowel disease
Icelandic: Lifur og gall Algengar
English: ANC < 1.0x109/1 and/or platelets < 50x109/1
Icelandic: ANC < 1,0 x 109/1 og/eða blóðflögur
English: Depending on your condition the usual starting dose is either 400 mg or 600 mg: - 400 mg to be taken as 4 tablets of 100 mg or 1 tablet of 400 mg once a day - 600 mg to be taken as 6 tablets of 100 mg or 1 tablet of 400 mg plus 2 tablets of 100 mg once a day.
Icelandic: Ef sólarhringsskammturinn er 800 mg (8 töflur með 100 mg eða 2 töflur með 400 mg) skal taka 4 töflur með 100 mg eða 1 töflu með 400 mg að morgni og 4 töflur með 100 mg eða 1 töflu með 400 mg að kvöldi.
English: (24 h), days 1, 15; 6-MP 25 mg/ m2 oral, days 1-20
Icelandic: MTX 500 mg/m2 i.v. (24 klst.), daga 1, 15; 6-MP 25 mg/m2 til inntöku, daga 1-20
English: Talk to your doctor before taking Imatinib Accord: - if you have or have ever had a liver, kidney or heart problem.
Icelandic: - ef þú ert með eða hefur einhvern tímann verið með lifrar-, nýrna- eða hjartasjúkdóm.
English: Posology for DFSP
Icelandic: Skammtar við DFSP
English: Consolidation therapy Alternating chemotherapy course: high dose chemotherapy with MTX 1 g/m2 i.v.
Icelandic: Háskammtakrabbameinslyfjameðferð með MTX 1 g/m2 i.v. (24 klst.), dag 1, og Ara-C
English: NAME OF THE MEDICINAL PRODUCT Imatinib Accord 400 mg film-coated tablets imatinib
Icelandic: Imatinib Accord 400 mg filmuhúðaðar töflur imatinib
English: In the event of recurrence of ANC < 1.0 x 109/l and/or platelets < 50 x 109/l, repeat step 1 and resume Imatinib Accord at reduced dose of 300 mg.
Icelandic: < 50 x 109/l skal endurtaka lið 1 og halda áfram með minni skammti af Imatinib Accord, þ.e. 300 mg.
English: The starting dose is 100 mg, to be taken as one tablet of 100 mg once a day.
Icelandic: - Ef þú ert í meðferð við HES/CEL Upphafsskammturinn er 100 mg, en þá er tekin ein tafla með 100 mg einu sinni á sólarhring.
English: You may become more sensitive to the sun while taking Imatinib Accord.
Icelandic: Þú getur orðið viðkvæmari fyrir sól meðan á meðferð með Glivec stendur.
English: Anaphylactic shock*
Icelandic: Æxlisblæðing/æxlisdrep*.
English: Acute respiratory failure11*, interstitial lung disease* Gastrointestinal disorders
Icelandic: Bráð öndunarbilun11*, millivefslungnasjúkdómur*.
English: Pancytopenia, febrile neutropenia
Icelandic: Rauðalosblóðleysi, segaöræðakvilli.
English: Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL).
Icelandic: Ofur-CVAD-skömmtun (hyper-CVAD regimen):
English: If you are being treated for MDS/MPD The starting dose is 400 mg to be taken as 4 tablets of 100 mg or one tablet of 400 mg once a day.
Icelandic: Upphafsskammturinn er 400 mg, en þá eru teknar 4 töflur með 100 mg eða 1 tafla með 400 mg einu sinni á sólarhring.
English: Treatment may be repeated for up to five consecutive days.
Icelandic: Meðferð má endurtaka í allt að fimm daga samfleytt.
English: ATCvet code: QA04AD90
Icelandic: QA04AD90
English: No data have been presented on overdoses in adult cats.
Icelandic: Engin gögn liggja fyrir um ofskömmtun hjá fullorðnum köttum.
English: Maropitant is effective against vomiting.
Icelandic: Marópítant er áhrifaríkt gegn uppköstum.
English: Plasma protein binding of maropitant in dogs is more than 99%.
Icelandic: Próteinbinding marópítants í plasma hjá hundum er yfir 99%.
English: Excipients: Benzyl alcohol (E1519)
Icelandic: Bensýlalkóhól (E1519)
English: Maropitant undergoes cytochrome P450 (CYP) metabolism in the liver.
Icelandic: Marópítant verður fyrir cýtókróm P450 (CYP) umbroti í lifur.
English: For the major metabolite 10.4% of the maropitant dose was recovered in urine and 9.3% in faeces.
Icelandic: 10,4% af aðalumbrotsefninu endurheimtist í þvagi og 9,3% í saur.
English: 11.1 mg For the full list of excipients, see section 6.1.
Icelandic: Sjá lista yfir öll hjálparefni í kafla 6.1.
English: Suomi/Finland Vetcare Finland Oy Hiomotie 3 A 00380 Helsinki Puh: 0201443360
Icelandic: Oy Hiomotie 3 A 00380 Helsinki Puh: 0201443360
English: Pack sizes of 1 vial of 10 ml, 20 ml, 25 ml or 50 ml.
Icelandic: Í hverri pakkningu er eitt 10 ml, 20 ml, 25 ml eða 50 ml hettuglas.
English: During clinical studies maropitant plasma levels conferred efficacy from 1 hour after administration.
Icelandic: Í klínískum rannsóknum voru plasmagildi marópítants farin að sýna virkni frá einni klukkustund eftir lyfjagjöf.
English: Due to the frequent occurrence of transient pain during subcutaneous injection, appropriate animal restraining measures may have to be applied.
Icelandic: Vegna þess að tímabundinn verkur kemur oft fram við inndælingu undir húð gæti þurft að nota viðeigandi aðferðir til að kyrrsetja dýrið.
English: In laboratory studies, maropitant has been shown to be a potential eye irritant.
Icelandic: Í rannsóknum á rannsóknastofum hefur komið í ljós að marópítant getur valdið augnertingu.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the label of the vial after EXP.
Icelandic: Ekki skal nota dýralyfið eftir fyrningardagsetningu sem tilgreind er á umbúðunum eftir EXP.
English: Apart from transient reactions at the injection site following subcutaneous administration, maropitant was well tolerated in dogs and young cats injected daily with up to 5 mg/kg (5 times the recommended dose) for 15 consecutive days (3-times the recommended duration of administration).
Icelandic: Fyrir utan tímabundin viðbrögð á stungustað eftir inndælingu undir húð þoldist marópítant vel í hundum og ungum köttum sem fengu allt að 5 mg/kg (5 sinnum ráðlagðan skammt) innspýtingu daglega í 15 daga samfleytt (3 sinnum ráðlagða tímalengd meðferðar).
English: This centre consists of several brainstem nuclei (area postrema, nucleus tractus solitarius, dorsal motor nucleus of the vagus) that receive and integrate sensory stimuli from central and peripheral sources and chemical stimuli from the circulation and the cerebro-spinal fluid.
Icelandic: Þessi stöð er gerð úr nokkrum frumukjörnum heilastofns (postrema reit, bragðskynskjarna (nucleus tractus solitarius), baklægum hreyfikjarna skreyjutaugar) sem taka við miðlægum og útlægum skyntaugaáreitum og samþætta þau og efnaáreitum úr blóðrásinni og heila- og mænuvökva.
English: Maropitant is a neurokinin 1 (NK1) receptor antagonist, which acts by inhibiting the binding of substance P, a neuropeptide of the tachykinin family.
Icelandic: Marópítant er neirókínín 1 (NK1) viðtakablokki sem verkar þannig að hann hamlar bindingu substance P, en það er neurópeptíð í takýkínínflokknum.
English: As maropitant is accumulated in the body during a 14 day treatment period due to metabolic saturation, careful monitoring of liver function and any adverse events should be implemented during long term treatment.
Icelandic: Þar sem marópítant safnast upp í líkamanum meðan á 14 daga meðferð stendur vegna mettunar umbrotsferla á að viðhafa nákvæmt eftirlit með lifrarstarfsemi, ásamt öllum aukaverkunum, meðan á langtímameðferð stendur.
English: Maropitant is highly bound to plasma proteins and may compete with other highly bound drugs.
Icelandic: Marópítant hefur mikla bindingu við plasmaprótein og getur keppt við önnur lyf með mikla bindingu.
English: Maropitant is metabolised in the liver and therefore should be used with caution in dogs and cats with liver disease.
Icelandic: Marópítant umbrotnar í lifur og á því að nota það með varúð hjá hundum og köttum með lifrarsjúkdóm.