FrancophonIA/ELRC3.0 huggingface dataset:
English: In patients currently taking Kaletra and starting lamotrigine: no dose adjustments to the recommended dose escalation of lamotrigine should be necessary.
Slovenian: Kaletra in pričnejo z uporabo lamotrigina: ni potrebno prilagajati odmerka na priporočeno povečanje odmerka lamotrigina.
English: At steady state, lopinavir protein binding remains constant over the range of observed concentrations after 400/100 mg Kaletra twice daily, and is similar between healthy volunteers and HIV-positive patients.
Slovenian: V stanju dinamičnega ravnovesja ostaja vezava lopinavirja na beljakovine v območju opazovanih koncentracij po 400/100 mg zdravila Kaletra dvakrat na dan stalna ter je pri zdravih prostovoljcih in pri HIV-pozitivnih bolnikih podobna.
English: The EC50 of lopinavir against the 56 baseline viral isolates ranged from 0.6 to 96-fold higher than the EC50 against wild type HIV.
Slovenian: EC50 lopinavirja proti 56 izhodiščnim virusnim izolatom je bila od 0,6- do 96-krat večja kot EC50 proti divjemu tipu HIV.
English: If this co-administration is judged unavoidable, increased dose of Kaletra at 400 mg/400 mg twice daily may be administered with rifampicin under close safety and therapeutic drug monitoring.
Slovenian: Če je takšna sočasna uporaba neizogibna, je mogoče večji odmerek zdravila Kaletra 400 mg/400 mg dvakrat na dan uporabiti z rifampicinom ob natančnem spremljanju varnosti in terapevtskem spremljanju koncentracij zdravil.
English: Turn the syringe so that the tip is pointing up, gently tap it and push plunger to remove any air bubbles.
Slovenian: Brizgo obrnite, tako da konica gleda navzgor in nežno potrkajte po njej ter potisnite bat, da odstranite morebitne zračne mehurčke.
English: Based on BSA (mg/m2)*
Slovenian: Na podlagi telesne površine (mg/m2)*
English: • If a side effect is preventing you from taking Kaletra as directed tell your doctor right away.
Slovenian: - Če vam neželen učinek prepreči, da bi zdravilo Kaletra jemali, kot je naročeno, to takoj povejte zdravniku.
English: • Breast-feeding mothers should not take Kaletra unless specifically directed by the doctor.
Slovenian: - Doječe matere ne smejo jemati zdravila Kaletra, razen če jim tega posebej ne naroči zdravnik.
English: What you need to know before you or your child takes Kaletra Do not take Kaletra if:
Slovenian: Kaj morate vedeti, preden boste vi ali vaš otrok vzeli zdravilo Kaletra Ne jemljite zdravila Kaletra če:
English: Repeat-dose toxicity studies in rodents and dogs identified major target organs as the liver, kidney, thyroid, spleen and circulating red blood cells.
Slovenian: Študije toksičnosti pri ponavljajočih odmerkih pri glodalcih in psih so pokazale, da so glavni ciljni organi jetra, ledvice, ščitnica, vranica in krožeče rdeče krvne celice.
English: Kaletra does not inhibit CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP2B6 or CYP1A2 at clinically relevant concentrations (see section 4.3).
Slovenian: CYP2C19, CYP2E1, CYP2B6 ali CYP1A2 (glejte poglavje 4.3).
English: Experienced patients received nevirapine plus up to two nucleoside reverse transcriptase inhibitors.
Slovenian: Izkušeni bolniki so dobili nevirapin ter do dva nukleozidna zaviralca reverzne transkriptaze.
English: Dosing should be less than 5 ml twice daily for children weighing less than 40 kg.
Slovenian: Za otroke, ki tehtajo manj kot 40 kg, mora biti odmerek manjši od 5 ml dvakrat na dan.
English: Based on the findings in a paediatric study (observed exposures were approximately 35% AUC12 and 75% lower Cmin than in adults), young children from 14 days to 3 months could have sub-optimal exposure with a potential risk of inadequate virologic suppression and emergence of resistance (see section 5.2).
Slovenian: 35 % AUC12 in 75 % nižje Cmin kot pri odraslih) bi mladi otroci, stari od 14 dni do 3 mesecev, lahko imeli suboptimalno izpostavljenost z možnim tveganjem za nezadostno virološko zavrtje in pojav rezistence (glejte poglavje 5.2).
English: If a child is unable to reliably swallow a Kaletra tablet, Kaletra oral solution formulation should be prescribed.
Slovenian: Če otrok ne zmore zanesljivo pogoltniti tablete zdravila Kaletra, mu morate predpisati peroralno raztopino zdravila Kaletra.
English: The following side effects have been reported by patients who took this medicine.
Slovenian: Bolniki, ki so jemali to zdravilo, so poročali o naslednjih neželenih učinkih.
English: Total amounts of alcohol and propylene glycol from all medicines, including Kaletra oral solution, that are to be given to infants should be taken into account in order to avoid toxicity from these excipients (see section 4.4).
Slovenian: Upoštevati je treba celokupno količino alkohola in propilenglikola v vseh zdravilih, ki jih bo prejel dojenček, vključno z zdravilom Kaletra peroralna raztopina, da bi se izognili toksičnosti teh pomožnih snovi (glejte poglavje 4.4).
English: • Haemophilia type A and B as Kaletra might increase the risk of bleeding.
Slovenian: - hemofilijo tipa A in B, ker zdravilo Kaletra lahko zviša tveganje za krvavitve.
English: AUC12 (µg•h/ml) Age ≥ 14 days to < 6 weeks cohort (N = 9):
Slovenian: AUC12 (µg•h/ml) Kohorta, v kateri je bila starost ≥ 14 dni do < 6 tednov (N = 9):
English: Co-administration of delamanid with a strong inhibitor of CYP3A (as lopinavir/ritonavir) may increase exposure to delamanid metabolite, which has been associated with QTc prolongation.
Slovenian: Sočasna uporaba delamanida z močnim zaviralcem CYP3A (kot je lopinavir/ritonavir) lahko poveča izpostavljenost presnovku delamanida, ki ga povezujejo s podaljšanjem intervala QTc.
English: However, if the benefit outweighs the risk, co-administration of bedaquiline with lopinavir/ritonavir must be done with caution.
Slovenian: Vendar pa je, če je korist večja od tveganja, pri sočasni uporabi bedakilina z lopinavirjem/ritonavirjem potrebna previdnost.
English: Monitoring plasma concentrations of methadone is recommended.
Slovenian: Priporočljivo je kontrolirati koncentracijo metadona v plazmi.
English: Before prescribing Kaletra 100/25 mg tablets, infants and young children should be assessed for the ability to swallow intact tablets.
Slovenian: Preden predpišete tablete zdravila Kaletra 100/25 mg, morate pri dojenčkih in majhnih otrocih oceniti, ali zmorejo pogoltniti cele tablete.
English: Valproate: ↓
Slovenian: Valproat: ↓
English: Kaletra contains 42% v/v alcohol.
Slovenian: Zdravilo Kaletra vsebuje 42 % v/v alkohola.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness: very common (≥1/10), common (≥ 1/100
Slovenian: V razvrstitvah pogostnosti so neželeni učinki navedeni po padajoči resnosti: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1000 do < 1/100) in neznani
English: Marked triglyceride elevation is a risk factor for development of pancreatitis.
Slovenian: Izrazito zvišanje trigliceridov je dejavnik tveganja za pankreatitis.
English: At week 48, the efficacy and safety with twice-daily dosing (n=87) in the paediatric population given lopinavir/ritonavir 100 mg/25 mg tablets was consistent with the efficacy and safety findings in previous adult and paediatric studies using lopinavir/ritonavir twice daily.
Slovenian: V 48. tednu sta bili učinkovitost in varnost odmerjanja dvakrat na dan v pediatrični populaciji (n=87), ki je prejemala lopinavir/ritonavir 100 mg/25 mg tablete skladni z ugotovitvami o učinkovitosti in varnosti pri predhodnih študijah pri odraslih in otrocih, kjer so uporabljali kombinacijo lopinavir/ritonavir dvakrat na dan.
English: In contrast, similar concentrations of lopinavir/ritonavir demonstrated no repolarisation delay in the canine cardiac Purkinje fibres.
Slovenian: Nasprotno pa podobne koncentracije lopinavirja/ritonavirja niso upočasnile repolarizacije v Purkinjejevih vlaknih srca psov.
English: Only at high inadvertent doses, it can cause headache and gastrointestinal upset.
Slovenian: Le v velikih, nenamernih odmerkih lahko povzroči glavobol in prebavne motnje.
English: When co-administered with Kaletra, sildenafil doses must not exceed 25 mg in 48 hours and tadalafil doses must not exceed 10 mg every 72 hours.
Slovenian: Med sočasno uporabo z zdravilom Kaletra odmerek sildenafila ne sme preseči 25 mg v 48 urah in odmerek tadalafila ne 10 mg na 72 ur.
English: • Muscle pain, tenderness or weakness, particularly in combination with these medicines.
Slovenian: - Bolečine, občutljivost ali šibkost mišic, zlasti v kombinaciji s protiretrovirusnimi zdravili.
English: 3rd Trimester n = 23
Slovenian: 3. trimesečje n = 23
English: Lopinavir is essentially completely metabolised by CYP3A.
Slovenian: Lopinavir se v bistvu popolnoma presnovi s CYP3A.
English: 3 tablets (300/75 mg)
Slovenian: 3 tablete (300/75 mg)
English: Instead, contact your doctor.
Slovenian: V takem primeru se posvetujte z zdravnikom.
English: Because lopinavir and ritonavir are highly protein bound, it is unlikely that they will be significantly removed by haemodialysis or peritoneal dialysis.
Slovenian: Ker sta lopinavir in ritonavir v veliki meri vezana na beljakovine, ni verjetno, da bi ju hemodializa ali peritonealna dializa odstranila v pomembni meri.
English: Activity of other protease inhibitors against isolates that developed incremental resistance to lopinavir after Kaletra therapy in protease inhibitor experienced patients: The presence of cross resistance to other protease inhibitors was analysed in 18 rebound isolates that had demonstrated evolution of resistance to lopinavir during 3 Phase II and one Phase III studies of Kaletra in protease inhibitorexperienced patients.
Slovenian: Dejavnost drugih zaviralcev proteaz proti izolatom, ki so razvili naraščajočo odpornost proti lopinavirju po zdravljenju z zdravilom Kaletra pri bolnikih, izkušenih z zaviralci proteaz: Obstoj navzkrižne odpornosti proti drugim zaviralcem proteaz so analizirali v 18 izolatih s preobratom; razvoj odpornosti proti lopinavirju so ugotovili med tremi študijami zdravila Kaletra II.
English: Place the dosing syringe in your child's mouth towards the cheek and gently push the plunger down to release the medicine.
Slovenian: Brizgo za peroralno dajanje vstavite otroku v usta v smeri proti licu in nežno potisnite bat navzdol, da zdravilo izteče.
English: Pharmacokinetic differences due to race have not been identified.
Slovenian: Prav tako niso ugotovili farmakokinetičnih razlik zaradi rase.
English: Fluvastatin or Pravastatin
Slovenian: Fluvastatin ali pravastatin
English: Not all pack sizes may be marketed.
Slovenian: Na trgu lahko ni vseh navedenih pakiranj.
English: No age or gender related pharmacokinetic differences have been observed in adult patients.
Slovenian: Pri odraslih bolnikih niso opazili s starostjo ali spolom povezanih farmakokinetičnih razlik.
English: The signs of toxicity observed in mice, rats or dogs included decreased activity, ataxia, emaciation, dehydration and tremors.
Slovenian: Med znaki toksičnosti pri miših, podganah ali psih so bili zmanjšana aktivnost, ataksija, huda shujšanost, dehidracija in tremor.
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymtomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Slovenian: Pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - combination antiretroviral therapy) nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične patogene in povzroči resna klinična stanja ali poslabšanje simptomov.
English: Phosphodiesterase (PDE5) inhibitors
Slovenian: Zaviralci fosfodiesteraze (PDE5)
English: What Kaletra looks like and contents of the pack
Slovenian: Izgled zdravila Kaletra in vsebina pakiranja
English: Based on weight (mg/kg)
Slovenian: Na podlagi telesne mase (mg/kg)
English: Antihistamines Astemizole Terfenadine
Slovenian: Antihistaminiki Astemizol Terfenadin
English: Inhaled, injectable or intranasal fluticasone propionate, budesonide, triamcinolone
Slovenian: Inhalirani, injicirani ali intranazalni flutikazonpropionat, budezonid, triamcinolon
English: Incremental resistance was most common in subjects whose baseline isolates had several protease inhibitor-associated mutations, but < 40-fold reduced susceptibility to lopinavir at baseline.
Slovenian: Naraščajoča odpornost je bila najpogostejša pri preiskovancih, ki so imeli v izhodiščnih izolatih več mutacij, povezanih z zaviralci proteaz, toda z izhodiščno < 40-kratno zmanjšano občutljivost za lopinavir.
English: Cortisol levels ↓ 86%
Slovenian: koncentracija v plazmi ↑ koncentracija kortizola ↓ 86%
English: • muscle disorders such as weakness and spasms, pain in the joints, muscles and back;
Slovenian: - mišične bolezni, kot so šibkost in krči, bolečine v sklepih, mišicah in hrbtu;
English: (see section 4.5); - riociguat is not recommended (see section 4.5); - vorapaxar is not recommended (see section 4.5); - fusidic acid in osteo-articular infections is not recommended (see section 4.5); - salmeterol is not recommended (see section 4.5); - rivaroxaban is not recommended (see section 4.5).
Slovenian: - riociguatom ni priporočljiva (glejte poglavje 4.5); - vorapaksarjem ni priporočljiva (glejte poglavje 4.5); - fusidno kislino pri osteoartikularnih okužbah ni priporočljiva (glejte poglavje 4.5); - salmeterolom ni priporočljiva (glejte poglavje 4.5); - rivaroksabanom ni priporočljiva (glejte poglavje 4.5).
English: Children were eligible when they were aged <18 years, ≥15 kg in weight, receiving cART that included lopinavir/ritonavir, HIV-1 ribonucleic acid (RNA) <50 copies/ml for at least 24 weeks and able to swallow tablets.
Slovenian: Otroci so bili primerni, če so bili stari <18 let, so tehtali ≥15 kg, so prejemali kombinirano protiretrovirusno zdravljenje, ki je vključevalo lopinavir/ritonavir, so imeli HIV-1 ribonukleinske kisline (RNA) <50 kopij/ml najmanj 24 tednov in so bili zmožni pogoltniti tablete.
English: Ranitidine: ↔
Slovenian: Ranitidin: ↔
English: Co-administration of voriconazole and low dose ritonavir (100 mg BID) as contained in Kaletra should be avoided unless an assessment of the benefit/risk to patient justifies the use of voriconazole.
Slovenian: Sočasni uporabi vorikonazola in majhnih odmerkov ritonavirja (100 mg dvakrat na dan), kot jih vsebuje zdravilo Kaletra, se je treba izogniti, razen če ocena koristi in tveganja pri bolniku upravičuje uporabo vorikonazola.
English: In children 14 days of age and older, the nature of the safety profile is similar to that seen in adults (see Table in section b).
Slovenian: d. Pediatrična populacija Pri otrocih, starih 14 dni in več, je varnostni profil podoben kot pri odraslih (glejte preglednico v razdelku b).
English: A dose adjustment of Kaletra 400 mg/400 mg (i.e. Kaletra 400/100 mg + ritonavir 300 mg) twice daily has allowed compensating for the CYP 3A4 inducer effect of rifampicin.
Slovenian: Prilagoditev odmerka zdravila Kaletra 400 mg/400 mg (tj. zdravilo Kaletra 400/100 mg + ritonavir 300 mg) dvakrat na dan je omogočila kompenzacijo indukcijskega učinka rifampicina na CYP3A4.
English: Further dosage reduction of rifabutin to 150 mg twice weekly on set days is recommended for patients in whom the 150 mg dose 3 times per week is not tolerated.
Slovenian: Nadaljnje zmanjševanje odmerka rifabutina na 150 mg 2-krat na teden ob določenih dnevih je priporočljivo pri bolnikih, ki ne prenašajo odmerka 150 mg 3-krat na teden.
English: Lamotrigine:
Slovenian: Lamotrigin:
English: The combination should be used with caution and a lower dose of trazodone should be considered.
Slovenian: Kombinacijo je treba uporabljati previdno; v poštev pride zmanjšanje odmerka trazodona.
English: The 5 bottle pack also contains five 5 ml syringes with 0.1 ml graduations.
Slovenian: Pakiranje s 5 plastenkami vsebuje tudi pet 5 ml brizg z 0,1 ml oznakami.
English: Mechanism of interaction
Slovenian: Mehanizem medsebojnega delovanja
English: If you or your child take more Kaletra than you should
Slovenian: Če ste vi ali vaš otrok vzeli večji odmerek zdravila Kaletra, kot bi smeli
English: Amiodarone, dronedarone
Slovenian: Amiodaron, dronedaron
English: • lower respiratory tract infection;
Slovenian: - okužbe spodnjih dihal;
English: Consequently, concomitant administration of Kaletra and these glucocorticoids is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4).
Slovenian: Zato sočasna uporaba zdravila Kaletra in teh glukokortikoidov ni priporočljiva, razen če možna korist zdravljenja odtehta tveganja sistemskih učinkov kortikosteroidov (glejte poglavje 4.4).
English: Therefore, the antiviral activity of Kaletra is due to lopinavir.
Slovenian: Protivirusno delovanje zdravila Kaletra je torej posledica lopinavirja.
English: Lopinavir binds to both alpha-1-acid glycoprotein (AAG) and albumin however, it has a higher affinity for AAG.
Slovenian: Lopinavir se veže na alfa-1-kisli glikoprotein (AKG) in na albumin, vendar ima večjo afiniteto za AKG.
English: • Taking Kaletra as recommended should give you the best chance of delaying the development of resistance to the product.
Slovenian: - Jemanje zdravila Kaletra po navodilih zagotavlja najboljšo možnost za odložitev pojava odpornosti proti temu zdravilu.
English: Table 8
Slovenian: Preglednica 8
English: The 4-oxo and 4-hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.
Slovenian: Glavna presnovka s protivirusnim delovanjem sta epimerni par 4-okso- in 4-hidroksimetabolita, vendar pomenita le neznaten delež skupne radioaktivnosti v plazmi.
English: Pimozide
Slovenian: Pimozid
English: Resistance to lopinavir, defined as the presence of any primary or active site mutations in protease (see above), was observed in 0/51 (0%) patients.
Slovenian: Odpornost proti lopinavirju, definirana kot prisotnost katerekoli primarne mutacije ali mutacije aktivnega mesta v proteazi (glejte zgoraj), je bila opažena pri 0/51 (0 %) bolnikih.
English: For caution on parenterally administered midazolam, see section 4.5.
Slovenian: Za previdnostne ukrepe pri parenteralni uporabi midazolama glejte poglavje 4.5.
English: Kaletra oral solution contains up to 0.3 g of glycerol per dose.
Slovenian: Peroralna raztopina zdravila Kaletra vsebuje do 0,3 g glicerola na odmerek.
English: At 30 weeks age of gestation, the dose was increased to 500/125 mg (two 200/50 mg tablets plus one 100/25 mg tablet) twice daily until subjects were 2 weeks postpartum.
Slovenian: Pri gestacijski dobi 30 tednov je bil odmerek povečan na 500/125 mg (dve 200/50 mg tableti plus eno 100/25 mg tableto) dvakrat dnevno, do 2 tednov po porodu.
English: • medicines used to lower blood cholesterol (e.g. atorvastatin, lovastatin, rosuvastatin or simvastatin);
Slovenian: - zdravila za zniževanje holesterola v krvi (npr. atorvastatin, lovastatin, rosuvastatin ali simvastatin);
English: • night sweats, itching, rash including raised bumps on the skin, infection of the skin, inflammation of skin or hair pores, accumulation of fluid in the cells or tissues.
Slovenian: - nočno potenje, srbenje, izpuščaj vključno z bulami na koži, okužbe kože, vnetje kože ali lasnih por, zastajanje tekočine v celicah ali tkivih.
English: 6/75 (8%) patients demonstrated new primary protease inhibitor mutations (codons 30, 32, 48, 50, 82, 84, 90), as did 12/77 (16%) patients in the BID group.
Slovenian: V skupini, ki je prejemala zdravilo 1 x dnevno, je 6/75 (8 %) bolnikov pokazalo nove primarne mutacije proteaznih zaviralcev (kodoni 30, 32, 48, 50, 82, 84, 90), kot tudi 12/77 (16 %) bolnikov v skupini, ki je prejemala zdravilo 2 x dnevno.
English: Each 1 ml of Kaletra oral solution contains 356.3 mg of alcohol and 152.7 mg of propylene glycol.
Slovenian: 1 ml zdravila Kaletra peroralna raztopina vsebuje 356,3 mg alkohola in 152,7 mg propilenglikola.
English: Nucleoside/Nucleotide reverse transcriptase inhibitors (NRTIs) Stavudine, Lamivudine Lopinavir: ↔
Slovenian: Nukleozidni in nukleotidni zaviralci reverzne transkriptaze (NRTI) Stavudin, lamivudin Lopinavir: ↔
English: In addition to the mutations described above, mutations V32I and I47A have been observed in rebound isolates with reduced lopinavir susceptibility from protease inhibitor experienced patients receiving Kaletra therapy, and mutations
Slovenian: Poleg zgoraj opisanih mutacij so opažali mutaciji V32I in I47A pri izolatih s preobratom, to je z manjšo občutljivostjo za lopinavir pri bolnikih izkušenih z zaviralci proteaz, ki so dobivali zdravilo Kaletra.
English: • morphine-like medicines (e.g. methadone);
Slovenian: - morfinu podobna zdravila (npr. metadon);
English: For volumes greater than 2 ml.
Slovenian: Za volumne, večje od 2 ml.
English: Mean age of patients enrolled was 41 years (range: 21 to 73); 51% were Caucasian and 66% were male.
Slovenian: Povprečna starost vključenih bolnikov je bila 41 let (razpon: od 21 do 73); 51 % je bilo belcev in 66 %
English: Initiation of digoxin in patients already taking Kaletra is likely to result in lower than expected increases of digoxin concentrations.
Slovenian: Uvedba digoksina bolnikom, ki že jemljejo zdravilo Kaletra, bo koncentracijo digoksina verjetno zvišala manj,
English: The other ingredients are:
Slovenian: Pomožne snovi so:
English: Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART - combination antiretroviral therapy) ali obojim.
English: AbbVie (logo)
Slovenian: AbbVie (logotip)
English: • Do not use Kaletra after the expiry date which is stated on the pack.
Slovenian: - Zdravila Kaletra ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pakiranju.
English: • ergotamine, dihydroergotamine, ergonovine, methylergonovine (used to treat headaches);
Slovenian: - ergotamin, dihidroergotamin, ergonovin, metilergonovin (uporabljajo se za zdravljenje glavobolov);
English: If you or your child is able to swallow tablets, Kaletra is also supplied as film-coated tablets containing 200 mg of lopinavir and 50 mg of ritonavir and film-coated tablets containing 100 mg of lopinavir and 25 mg of ritonavir.
Slovenian: Če vi ali vaš otrok nimate težav s požiranjem tablet, je zdravilo Kaletra na voljo tudi v obliki filmsko obloženih tablet, ki vsebujejo 200 mg lopinavirja in 50 mg ritonavirja ter v obliki filmsko obloženih tablet, ki vsebujejo 100 mg lopinavirja in 25 mg ritonavirja.
English: All patients were non-nucleoside reverse transcriptase inhibitor naïve.
Slovenian: Vsi bolniki so bili naivni za nenukleozidne zaviralce reverzne transkriptaze.
English: Patients had not been on prior lopinavir/ritonavir therapy.
Slovenian: Bolniki pred tem niso bili zdravljeni z lopinavirjem/ritonvirjem.
English: AUC: ↑ 5.9-fold
Slovenian: AUC: ↑ 5,9-krat
English: In vitro experiments with human hepatic microsomes indicate that lopinavir primarily undergoes oxidative metabolism.
Slovenian: Poskusi s človeškimi jetrnimi mikrosomi in vitro kažejo, da je presnova lopinavirja predvsem oksidacijska.
English: (combinations of mechanisms including CYP3A inhibition)
Slovenian: (kominacija mehanizmov, vključno z zavrtjem CYP3A)
English: Lower concentrations of lopinavir/ritonavir did not produce significant potassium (HERG) current blockade.
Slovenian: Manjše koncentracije lopinavirja/ritonavirja niso pomembno zavrle kalijevega toka (HERG).
English: In the QD group,
Slovenian: vključno s podaljšanjem QT,