FrancophonIA/ELRC3.0 huggingface dataset:
English: Over the 200-1,000-mg dose range administered in both volunteers and HIV infected patients, there was a slightly greater than dose-proportional increase in urinary recovery of indinavir.
Slovenian: Pri odmerkih med 200 in 1000 mg je tako pri prostovoljcih kot tudi pri s HIV okuženih bolnikih prišlo do izločanja indinavirja v urinu v koncentracijah, ki so bile rahlo višje, kot bi to bilo sorazmerno z odmerkom.
English: For sildenafil and tadalafil, same recommendations as for indinavir without ritonavir boosting (see Table 1).
Slovenian: Pri sildenafilu in tadalfilu veljajo enaka priporočila kot pri indinavirju, ki ni okrepljen z ritonavirjem (glejte tabelo 1).
English: Indinavir at concentrations of 25 to 100 nM mediated 95 % inhibition of viral spread in cultures of mitogen-activated human peripheral blood mononuclear cells infected with diverse, primary clinical isolates of HIV 1, including isolates resistant to zidovudine and nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Slovenian: Indinavir je v koncentracijah od 25 do 100 nM povzročil 95 % inhibicijo virusnega širjenja v kulturah z mitogenom aktiviranih človeških perifernih krvnih enojedrnih celic, okuženih z različnimi, primarno kliničnimi izolati HIV-1, vključno z izolati, odpornimi na zidovudin in nenukleozidne zaviralce reverzne transkriptaze (NNRTI - "nonnucleoside reverse transcriptase inhibitor").
English: This could be dry toast with jam or cornflakes with skimmed or low-fat milk and sugar.
Slovenian: To je na primer suh kruh z marmelado ali koruzni kosmiči s posnetim ali nemastnim mlekom in sladkorjem.
English: Divalproex, lamotrigine, phenytoin
Slovenian: Divalproeks, lamotrigin, fenitoin
English: In rats, at similar exposure levels, an increased incidence of thyroid adenomas was seen, probably related to an increase in release of thyroid stimulating hormone secondary to an increase in thyroxine clearance.
Slovenian: Pri podganah so pri podobnih stopnjah izpostavljenosti opazili povečano pojavnost adenomov ščitnice, verjetno v povezavi s povečanim sproščanjem TSH kot posledici povečanega očistka tiroksina.
English: increases in MCV, decreases in neutrophils increased spontaneous bleeding in patients with haemophilia, anemia including acute haemolytic anaemia, thrombocytopenia (see section 4.4).
Slovenian: zvišanje MCV, zmanjšanje števila nevtrofilcev povečanje pojava spontanih krvavitev pri bolnikih s hemofilijo, anemija vključno z akutno hemolitično anemijo, trombocitopenija (glejte poglavje 4.4).
English: In patients with mild-to-moderate hepatic impairment due to cirrhosis, the dose of indinavir should be reduced to 600 mg every 8 hours.
Slovenian: Pri bolnikih z blago do zmerno jetrno okvaro zaradi ciroze je treba odmerek indinavirja zmanjšati na 600 mg vsakih 8 ur.
English:  atorvastatin concentration Atorvastatin is less dependent on CYP3A4 for metabolism than lovastatin or simvastatin
Slovenian:  koncentracija atorvastatina Presnova atorvastatina je manj odvisna od CYP3A4 kot presnova pri lovastatinu ali simvastatinu.
English: • ‘haemophilia' - CRIXIVAN may make you more likely to bleed.
Slovenian: • 'hemofilija' - zdravilo CRIXIVAN lahko povzroči večjo nagnjenost h krvavitvam.
English: Capsule content anhydrous lactose magnesium stearate
Slovenian: Vsebina kapsule brezvodna laktoza magnezijev stearat
English: Indinavir boosted regimen.
Slovenian: Režim z okrepljenim indinavirjem.
English: Indinavir at concentrations of 50 to 100 nM mediated 95 % inhibition (IC95) of viral spread (relative to an untreated virus-infected control) in human T-lymphoid cell cultures and primary human monocytes/macrophages infected with HIV 1 variants LAI, MN, RF, and a macrophage-tropic variant SF-162, respectively.
Slovenian: Indinavir je v koncentracijah od 50 do 100 nM povzročil 95 % inhibicijo (IC95) virusnega širjenja (relativno glede na z virusom okuženo nezdravljeno kontrolo) v kulturah človeških T-limfoidnih celic in primarnih človeških monocitih/makrofagih, okuženih s HIV-1 različicami LAI, MN, RF oz. makrofagotropično različico SF-162.
English: Amprenavir AUC: ↑ 90 % Indinavir: ↔
Slovenian: AUC amprenavirja: ↑ 90 % Indinavir: ↔
English: • theophylline - used for asthma
Slovenian: • teofilin - za astmo
English: Method of administration The hard capsules should be swallowed whole.
Slovenian: Način uporabe Trde kapsule je treba pogoltniti cele.
English: • fexofenadine, loratidine - antihistamines used for hay fever and other allergic conditions
Slovenian: • feksofenadin, loratidin - antihistaminika za seneni nahod in ostale alergije
English: If you stop taking CRIXIVAN
Slovenian: Če ste prenehali jemati zdravilo CRIXIVAN
English: Boosted indinavir (indinavir with ritonavir) may have additive pharmacokinetic effects on substances that share the CYP3A4 pathway as both ritonavir and indinavir inhibit the cytochrome P450 enzyme CYP3A4.
Slovenian: Okrepljeni indinavir (indinavir in ritonavir) ima lahko dodatne farmakokinetične učinke na snovi, ki se presnavljajo preko CYP3A4, saj ritonavir in indinavir zavirata encim CYP3A4 citokroma P450.
English: No carcinogenicity was noted in mice at the maximum tolerated dose, which corresponded to a systemic exposure approximately 2 to 3 times higher than the clinical exposure.
Slovenian: Pri miših pri maksimalnem tolerabilnem odmerku, ki ustreza približno 2- do 3-krat višji sistemski izpostavljenosti, kot je klinična izpostavljenost, karcinogenosti niso opazili.
English: Concomitant use of indinavir with lovastatin or simvastatin is not recommended due to an increased risk of myopathy including rhabdomyolysis.
Slovenian: Sočasne uporabe indinavirja z lovastatinom ali simvastatinom ne priporočamo zaradi zvečanega tveganja za miopatijo vključno z rabdomiolizo.
English: • The other ingredients are anhydrous lactose, magnesium stearate, gelatin and titanium dioxide
Slovenian: • Druge sestavine zdravila so brezvodna laktoza, magnezijev stearat, želatina in titanov dioksid
English: • fluconazole - used for fungal infections
Slovenian: • flukonazol - za glivične okužbe
English: No external, visceral, or skeletal changes were observed in rabbits or dogs.
Slovenian: Pri kuncih in psih niso ugotovili nobenih zunanjih, visceralnih ali skeletnih sprememb.
English: ANALGESICS Fentanyl
Slovenian: ANALGETIKI Fentanil
English: Increased methadone dose may be necessary when concomitantly administered with indinavir/ritonavir.
Slovenian: Morda bo treba povečati odmerek metadona, kadar se daje sočasno z indinavirjem/ritonavirjem.
English: No specific interaction studies have been performed with the boosted dose 400 mg indinavir with 100 mg ritonavir.
Slovenian: Posebnih študij medsebojnega delovanja z indinavirjem 400 mg, okrepljenim z ritonavirjem 100 mg, niso opravili.
English: • if you are taking any of the following medicines: - fusidic acid - an antibiotic used to treat infections - piroxicam - used for arthritis - alfuzosin - used for prostate problems - bepridil - used for chest pain (angina) - clozapine - used for some mental health problems - pethidine or propoxyphene - used for pain - estazolam or flurazepam - used to help you sleep - clorazepate or diazepam - used to make you calmer - encainide, flecanide, propafenone, or quinidine - used for uneven heartbeat problems.
Slovenian: • če jemljete katero od naslednjih zdravil: - fusidno kislino - antibiotik, ki se uporablja za zdravljenje okužb - piroksikam - uporablja se za zdravljenje artritisa - alfuzosim - uporablja se pri težavah s prostato - bepridil - uporablja se pri bolečinah v prsnem košu (angina pektoris) - klozapin - uporablja se pri nekaterih mentalnih zdravstvenih težavah - petidin ali propoksifen - uporabljata se pri bolečinah - estazolam ali flurazepam - uporabljata se za lažje spanje - klorazepat ali diazepam - uporabljata se za pomiritev - enkainid, flekanid, propafenon ali kinidin - uporabljajo se pri težavah z nerednim bitjem srca
English: Indinavir AUC:  92 % (Relative to Indinavir 800 mg TID alone) This effect is due to an induction of CYP3A4 by rifampicin.
Slovenian: AUC indinavirja:  92 % (glede na samostojno uporabljen 800 mg TID) Ta učinek je posledica indukcije CYP3A4, ki jo povzroča rifampicin.
English: Stavudine AUC: ↑ 21 % Stavudine Cmin: not evaluated
Slovenian: AUC stavudina: ↑ 21% Cmin stavudina: niso ocenili
English: • amprenavir, saquinavir, atazanavir - used for HIV
Slovenian: • amprenavir, sakvinavir, atazanavir - za okužbe s HIV
English: ANTICONVULSANTS Carbamazepine, phenobarbital phenytoin
Slovenian: ANTIKONVULZIVI Karbamazepin, fenobarbital fenitoin
English: Calcium channel blockers are metabolized by CYP3A4 which is inhibited by indinavir.
Slovenian: Blokatorji kalcijevih kanalčkov se presnavljajo s CYP3A4, ki ga indinavir zavira.
English: Treatment with indinavir alone or in combination with other antiretroviral agents (i.e., nucleoside analogues) has so far been documented to reduce viral load and increase CD4 lymphocytes in patients with CD4 cell counts below 500 cells/mm
Slovenian: Doslej so ugotovili, da zdravljenje z indinavirjem samim ali v kombinaciji z drugimi protiretrovirusnimi zdravili (npr. nukleozidnimi analogi) zmanjša virusno obremenitev in poveča število CD4 limfocitov pri bolnikih s številom CD4 celic, manjšim od 500 celic/mm
English: Cyclosporine A (CsA) levels markedly increase in patients on PIs, including indinavir.
Slovenian: Ravni ciklosporina A (CsA) se pri bolnikih, ki jemljejo zaviralce proteaze, vključno z indinavirjem, znatno zvišajo.
English: IMMUNOSUPPRESSIVES Cyclosporine A (Indinavir/ritonavir 800/100 BID)
Slovenian: IMUNOSUPRESIVNA ZDRAVILA Ciklosporin A (indinavir/ritonavir 800/100 BID)
English: If any of the above apply to you (or you are not sure), talk to your doctor, pharmacist or nurse before taking CRIXIVAN.
Slovenian: Če kar koli od naštetega velja za vas (ali če niste prepričani), se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro, preden vzamete zdravilo CRIXIVAN.
English: The mean indinavir plasma AUC0-8hr at week 30-32 of gestation (n = 11) was 9,231 nMhr, which is 74 % (95 % CI: 50 %, 86 %) lower than that observed 6 weeks postpartum.
Slovenian: Povprečna plazemska AUC0-8hr indinavirja je v 30. do 32. tednu gestacije (n=11) znašala 9231 nM*h, kar je 74 % (95 % CI: 50%, 86 %) manj kot 6 tednov po porodu.
English: CALCIUM CHANNEL BLOCKERS Dihydropyridine: e.g., felodipine, nifedipine, nicardipine
Slovenian: BLOKATORJI KALCIJEVIH KANALČKOV Dihidropiridin: na primer felodipin, nifedipin, nicardipin.
English: Based on an interaction study with lopinavir/ritonavir, combination of rosuvastatin and protease inhibitors is not recommended.
Slovenian: Glede na študijo medsebojnega delovanja lopinavirja in ritonavirja kombinacija rosuvastatina in zaviralcev proteaze ni priporočljiva.
English: Indinavir with or without ritonavir should not be administered concurrently with medicinal products with narrow therapeutic windows and which are substrates of CYP3A4.
Slovenian: Indinavir se v kombinaciji z ritonavirjem ali brez njega ne sme dajati sočasno z zdravili z ozkim terapevtskim oknom, ki so substrati CYP3A4.
English: Anti-Mycobacterial Rifabutin
Slovenian: Antimikobakterijska zdravila Rifabutin
English: Nephrolithiasis and tubulointerstitial nephritis
Slovenian: Ledvični kamni in tubulointersticijski nefritis
English: Patients with mild-to-moderate hepatic insufficiency and clinical evidence of cirrhosis had evidence of decreased metabolism of indinavir resulting in approximately 60 % higher mean AUC following a 400-mg dose.
Slovenian: Pri bolnikih z blago do zmerno jetrno okvaro in kliničnimi znaki ciroze je bila presnova indinavirja zmanjšana, kar je povzročilo približno 60 % višjo povprečno vrednost AUC po 400 mg odmerku.
English: Manufacturer: Merck Sharp & Dohme B.V., Waarderweg 39, Postbus 581, 2003 PC Haarlem The Netherlands
Slovenian: Izdelovalec: Merck Sharp & Dohme B.V., Waarderweg 39, Postbus 581, 2003 PC Haarlem, Nizozemska
English: Not studied, combined administrations are expected to significantly increase concentrations of midazolam, particularly when midazolam is given orally.
Slovenian: Pričakuje se, da kombinirana uporaba pomembno poveča koncentracije midazolama, predvsem kadar se midazolam daje peroralno.
English: 180 hard capsules 270 hard capsules 360 hard capsules
Slovenian: 180 trdih kapsul 270 trdih kapsul 360 trdih kapsul
English: Ritonavir increases the serum levels of amprenavir as a result of CYP3A4 inhibition.
Slovenian: Ritonavir zviša raven amprenavirja, kar je posledica inhibicije CYP3A4.
English: Indinavir AUC and Cmin: ↔ (Relative to Indinavir 400 mg SD)  Quinidine concentration expected (CYP3A4 inhibition by indinavir)
Slovenian: AUC in Cmin indinavirja: ↔ (glede na indinavir 400 mg SD)  pričakovana koncentracija kinidina (inhibicija CYP3A4, ki jo povzroča indinavir)
English: Interactions and dose recommendations with other medical products - INDINAVIR BOOSTED WITH RITONAVIR.
Slovenian: Tabela 2: Medsebojno delovanje in priporočeni odmerki z drugimi zdravili - INDINAVIR, OKREPLJEN Z RITONAVIRJEM.
English: HMG-CoA REDUCTASE INHIBITORS
Slovenian: ZAVIRALCI REDUKTAZE HMG CoA
English: In some patients, resolution of the interstitial nephritis did not occur following discontinuation of indinavir therapy; renal insufficiency, renal failure, leucocyturia (see section 4.4).
Slovenian: Pri nekaterih bolnikih se intersticijski nefritis po prenehanju zdravljenja z indinavirjem ni popravil; ledvična insuficienca; odpoved ledvic; levkociturija (glejte poglavje 4.4)
English: Do not take either CRIXIVAN or ritonavir if any of the above applies to you.
Slovenian: Ne jemljite niti zdravila CRIXIVAN niti ritonavirja, če kar koli od naštetega velja za vas.
English: Interaction not studied.
Slovenian: Interakcije niso preučevali.
English: headache, dizziness insomnia, hypoaesthesia; paraesthesia oral paraesthesia.
Slovenian: glavobol, omotica nespečnost, hipestezija, parestezija oralna parestezija
English: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Slovenian: Pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - ˝combination antiretroviral therapy˝) nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične patogene in povzroči resna klinična stanja ali poslabšanje simptomov.
English: ANTIDEPRESSANTS Trazodone 50 mg SD Ritonavir 200 mg BID
Slovenian: ANTIDEPRESIVI Trazodon 50 mg SD Ritonavir 200 mg BID
English: Adverse reactions, including nephrolithiasis, may lead to treatment interruption.
Slovenian: Neželeni učinki, vključno z ledvičnimi kamni, lahko privedejo do prekinitve zdravljenja.
English: The following side effects have also been reported since the medicine has been used.
Slovenian: V času, odkar je zdravilo v uporabi, so poročali tudi o naslednjih neželenih učinkih.
English: Dose reduction of rifabutin and dose increase of Crixivan has not been confirmed in clinical studies.
Slovenian: Zmanjšanje odmerka rifabutina in povečanje odmerka zdravila Crixivan v kliničnih študijah ni bilo dokazano zato se sočasno jemanje ne priporoča.
English: Indinavir alone or in combination with nucleoside analogues (zidovudine/stavudine and lamivudine) has been shown to delay clinical progression rate compared with nucleoside analogues and to provide a sustained effect on viral load and CD4 count.
Slovenian: Pokazalo se je, da indinavir sam ali v kombinaciji z nukleozidnimi analogi (zidovudin/stavudin in lamivudin) v primerjavi z nukleozidnimi analogi povzroči zakasnitev stopnje kliničnega napredovanja bolezni ter zagotovi trajni učinek na virusno obremenitev in število CD4.
English: Corresponding plasma concentrations at 8 hours post dose were 220 nM, 210 nM and 370 nM, respectively.
Slovenian: Osem ur po vsakem odmerku pa so bile odgovarjajoče plazemske koncentracije 220 nM, 210 nM in 370 nM.
English: With the exception of dry skin, rash, and taste perversion, the incidence of clinical adverse reactions was similar or higher among patients treated with antiretroviral nucleoside analogue controls than among patients treated with CRIXIVAN monotherapy or in combination with NRTI(s).
Slovenian: Z izjemo suhe kože, izpuščaja in motenj okušanja je bila pojavnost vseh teh kliničnih neželenih učinkov pri bolnikih, ki so se zdravili s primerjalnimi protiretrovirusnimi nukleozidnimi analogi, podobna ali višja kot pri bolnikih, ki so se zdravili z zdravilom CRIXIVAN samim ali v kombinaciji z NRTI.
English: Indinavir should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Slovenian: Ustreznih in dobro kontroliranih raziskav na nosečih ženskah ni. Indinavir lahko med nosečnostjo uporabljamo le, če njegova možna korist upraviči možno tveganje za plod.
English: Interactions between indinavir and other medicinal products are listed in the tables below (increase is indicated as “↑”, decrease as “↓”, no change (≤ +/- 20 %) as “↔”, single dose as “SD”, once daily as “QD”, twice daily as “BID”, three times daily as “TID”, and four times daily as "QID").
Slovenian: Medsebojno delovanje indinavirja in drugih zdravil je navedeno v spodnjih tabelah (povečanje je označeno kot "↑", zmanjšanje kot "↓", brez spremembe (≤ +/- 20 %) kot "↔", enkratni odmerek kot "SD", enkrat na dan kot "QD", dvakrat na dan kot "BID", trikrat na dan kot "TID" in štirikrat na dan kot "QID").
English: Ritonavir may increase digoxin levels due to modification of P-glycoprotein mediated digoxin efflux.
Slovenian: Ritonavir lahko zviša ravni digoksina zaradi spremembe sproščanja digoksina, ki ga povzroča P-glikoprotein.
English: Indinavir and norethindrone/ethinyl estradiol 1/35 can be coadministered without dose adjustment.
Slovenian: Indinavir in noretindron/etinilestradiol 1/35 se lahko dajejo sočasno brez prilagajanja odmerka.
English: Concurrent use of indinavir with rifampicin or herbal preparations containing St John's wort (Hypericum perforatum) is contraindicated.
Slovenian: Sočasno jemanje indinavirja in rifampicina ali zeliščnih pripravkov, ki vsebujejo šentjanževko (Hypericum perforatum) je kontraindicirano.
English: • The capsules are printed with printing ink containing indigo carmine (E 132).
Slovenian: • Kapsule so potiskane s tiskarskim črnilom, ki vsebuje indigo karmin (E 132).
English: Posology The recommended dose of indinavir is 800 mg orally every 8 hours.
Slovenian: Odmerjanje Priporočeni odmerek indinavirja je 800 mg peroralno vsakih 8 ur.
English: Evaluation may consist of urinalysis, serum BUN and creatinine, and ultrasound of the bladder and kidneys.
Slovenian: Pregled lahko vključuje analizo urina, določitev dušika sečnine v krvi in kreatinina v serumu ter ultrazvok mehurja in ledvic.
English: rash, dry skin pruritus rash including erythema multiforme and Stevens Johnson syndrome, hypersensitivity vasculitis, alopecia, hyperpigmentation, urticaria; ingrown toenails and/or paronychia.
Slovenian: izpuščaj, suha koža pruritus izpuščaj, vključno z multiformnim eritemom in Stevens-Johnsonovim sindromom, hipersenzitivni vaskulitis, alopecija, hiperpigmentacija, urtikarija, vraščeni nohti na nožnih prstih in/ali paronihija
English: Do not take CRIXIVAN if any of the above applies to you.
Slovenian: Ne jemljite zdravila CRIXIVAN, če kar koli od naštetega velja za vas.
English: Seven major metabolites were identified and the metabolic pathways were identified as glucuronidation at the pyridine nitrogen, pyridine-N-oxidation with and without 3'-hydroxylation on the indane ring, 3'-hydroxylation of indane, p-hydroxylation of phenylmethyl moiety, and N-depyridomethylation with and without the 3'-hydroxylation.
Slovenian: Odkritih je bilo sedem glavnih presnovkov in poti presnove, kot so: glukuronidacija na piridinskem dušiku, oksidacija piridinskega dušika s hidroksilacijo na mestu 3´ indanskega obroča ali brez nje, hidroksilacija indana na mestu 3´, hidroksilacija fenilmetilne skupine na mestu para in demetilacija piridinskega dušika s hidroksilacijo na mestu 3´ ali brez nje.
English: The use of indinavir/ritonavir with quinidine is contraindicated.
Slovenian: Uporaba indinavirja/ritonavirja skupaj s kinidinom je kontraindicirana.
English: Interactions between indinavir/ritonavir and other medicinal products are listed in the tables below (increase is indicated as “↑”, decrease as “↓”, no change (≤ +/- 20 %) as “↔”, single dose as “SD”, once daily as “QD”, twice daily as “BID”, three times daily as “TID”, and four times daily as "QID").
Slovenian: Medsebojno delovanje indinavirja/ritonavirja in drugih zdravil je navedeno v spodnjih tabelah (povečanje je označeno kot "↑", zmanjšanje kot "↓", brez spremembe (≤ +/- 20 %) kot "↔", enkratni odmerek kot "SD", enkrat na dan kot "QD", dvakrat na dan kot "BID", trikrat na dan kot "TID" in štirikrat na dan kot "QID").
English: Loratidine
Slovenian: Loratidin
English: The relevance of these findings for ritonavir boosted indinavir is unknown.
Slovenian: Pomembnost teh dognanj z vidika učinka ritonavirja na povišanje koncentracije indinavirja ni znana.
English: Delavirdine 400 mg TID Indinavir 400 mg TID
Slovenian: Delavirdin 400 mg TID Indinavir 400 mg TID
English: Indinavir inhibits CYP3A4 and as a result is expected to markedly increase the plasma concentrations of these HMG-CoA reductase inhibitors, which are highly dependent on CYP3A4 metabolism.
Slovenian: Indinavir zavira CYP3A4, zato se pričakuje, da bo precej povečal koncentracije teh zaviralcev reduktaze HMG-CoA v plazmi, ki so zelo odvisne od presnove CYP3A4.
English: 90 hard capsules 180 hard capsules
Slovenian: 90 trdih kapsul 180 trdih kapsul
English: Following a dose regimen of 800 mg every 8 hours, measured peak plasma concentrations (Cmax) after morning, afternoon and evening doses were 15,550 nM, 8,720 nM and 8,880 nM, respectively.
Slovenian: Po jemanju 800 mg odmerkov vsakih 8 ur so najvišje plazemske koncentracije (Cmax) znašale 15.550 nM po jutranjem, 8.720 nM po popoldanskem in 8.880 nM po večernem odmerku.
English: Amprenavir 1,200 mg BID AUC ↑90 % with 800 mg TID indinavir alone (see Table 1).
Slovenian: AUC amprenavirja 1200 mg BID ↑ 90 % s samostojnim indinavirjem 800 mg TID (glejte tabelo 1).
English: Not known* new onset diabetes mellitus or hyperglycaemia, or exacerbation of pre-existing diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia.
Slovenian: Presnovne in prehranske motnje neznana* pojav sladkorne bolezni ali hiperglikemije ali poslabšanje že obstoječe sladkorne bolezni, hipertrigliceridemija, hiperholesterolemija
English: Co-administration of CRIXIVAN with sildenafil, tadalafil and vardenafil (PDE5 inhibitors) are expected to substantially increase the plasma concentrations of these compounds and may result in an increase in PDE5 inhibitor-associated adverse events, including hypotension, visual changes, and priapism (see section 4.5).
Slovenian: Pri sočasni uporabi zdravila CRIXIVAN in sildenafila, tadalfila in vardenafila (zaviralcev PDE5) pričakujemo znatno povečanje plazemskih koncentracij teh snovi, kar lahko povzroči več z zaviralci PDE5 povezanih neželenih učinkov, vključno s hipotenzijo, spremembami vida in priapizemom (glejte poglavje 4.5).
English: CRIXIVAN contains lactose
Slovenian: Zdravilo CRIXIVAN vsebuje laktozo
English: Dose reduction of CRIXIVAN to 400-600 mg every 8 hours should be considered.
Slovenian: Treba je razmisliti o zmanjšanju odmerka zdravila CRIXIVAN na 400-600 mg na vsakih 8 ur.
English: Developmental Toxicity
Slovenian: Toksični učinki na razvoj
English: Ritonavir AUC ↓ 36 % Ritonavir Cmin: 39 %
Slovenian: AUC ritonavirja ↓ 36 % Cmin ritonavirja:  39 %
English: Same recommendations as for indinavir without ritonavir boosting (see Table 1).
Slovenian: Enaka priporočila kot pri indinavirju, ki ni okrepljen z ritonavirjem (glejte tabelo 1).
English: ANTICONVULSANTS Carbamazepine
Slovenian: ANTIKONVULZIVI Karbamazepin