FrancophonIA/ELRC3.0 huggingface dataset:
English: Possible preventive measures such as limited exposure to sunlight and UV rays and, in case of exposure, adequate protection should be advised to the patients in order to minimize the risk of skin cancer.
Croatian: Bolesnicima je potrebno savjetovati moguće preventivne mjere kao što je ograničena izloženost sunčevoj svjetlosti i UV zrakama i, u slučaju izloženosti, odgovarajuća zaštita, radi minimiziranja rizika od raka kože.
English: The CHMP also carried out a risk assessment for patients previously exposed to NDMA and NDEA in sartans and calculated daily intake levels based on the principles of ICH M7(R1) which are associated with an additional lifetime risk of 1 in 100,000 patients.
Croatian: CHMP je također proveo procjenu rizika za bolesnike koji su prethodno bili izloženi tvarima NDMA i NDEA u sartanima te je izračunao razinu dnevnog unosa na temelju načela Smjernica ICH M7(R1) koja su povezana s dodatnim doživotnim rizikom od 1 na 100 000 bolesnika.
English: Irbesartan had no effect upon fertility of treated rats and their offspring up to the dose levels inducing the first signs of parental toxicity (see section 5.3).
Croatian: Irbesartan nije utjecao na fertilitet liječenih štakora ili njihovog potomstva sve do onih doza koje izazivaju prve znakove toksičnosti u roditelja (vidjeti dio 5.3).
English: Debrecen H-4042
Croatian: Pallagi út 13. Debrecen H-4042
English: Frequency ‘not known': Skin and lip cancer (Non-melanoma skin cancer)
Croatian: Učestalost „nepoznata”: Rak kože i usana (nemelanomski rak kože)
English: One study included a population comprised of 71,533 cases of BCC and of 8,629 cases of SCC matched to 1,430,833 and 172,462 population controls, respectively.
Croatian: Jedna studija uključila je populaciju koja se sastojala od 71 533 slučaja BCC-a i 8629 slučajeva SCC-a usklađenih s 1 430 833,
English: Risks resulting from multiple exposures are considered to add up in patients as mutagenic carcinogens are currently considered as summation toxins.
Croatian: Smatra se da se rizici koji proizlaze iz višekratnog izlaganja bolesnika zbrajaju jer se mutagene tvari kancerogenih svojstava trenutačno smatraju kumulativnim toksinima.
English: Thus, the risk assessment is based on a potential worst case scenario, which would be a partially combined exposure to the highest levels of NDEA for 4 years (2011 - 2015) and to NDMA for 6 years (2012 - 2018) reported from a sartan, resulting in a cumulative theoretical excess cancer risk of 29.5:100,000 or 1:3390 (0.029%) when extrapolated from the available rat studies according to ICH M7(R1).
Croatian: Stoga se procjena rizika temelji na potencijalnom najgorem scenariju, odnosno djelomično kombiniranoj izloženosti najvišim razinama tvari NDEA tijekom četiri godine (2011. - 2015.) i NDMA tijekom šest godina (2012. - 2018.) koje su zabilježene za sartan, što ima za posljedicu kumulativni teoretski prekomjerni rizik od razvoja raka od 29,5 : 100 000 ili 1 : 3 390 (0,029 %) pri ekstrapolaciji iz dostupnih ispitivanja na štakorima na temelju Smjernica ICH M7(R1).
English: These findings were also observed with lower doses of this other angiotensin-II antagonist when given in combination with hydrochlorothiazide.
Croatian: Ovi nalazi su također zapaženi pri nižim dozama tog drugog antagonista angiotenzina II kad se davao u kombinaciji s hidroklorotiazidom.
English: In vitro studies indicate that irbesartan is primarily oxidised by the cytochrome P450 enzyme CYP2C9; isoenzyme CYP3A4 has negligible effect.
Croatian: In vitro studije upućuju da se irbesartan primarno oksidira pomoću enzima CYP2C9 citokroma P450; izoenzim CYP3A4 ima neznatan učinak.
English: If a child swallows some tablets, contact your doctor immediately.
Croatian: Ako dijete proguta tablete, odmah se obratite svom liječniku.
English: Additional measures are needed to minimise prospectively the reoccurrence of such contamination.
Croatian: Potrebne su dodatne mjere kako bi se ponovna pojava takve kontaminacije prospektivno smanjila na najmanju moguću mjeru.
English: It is important that you continue to take Irbesartan/Hydrochlorothiazide Teva until your doctor tells you otherwise.
Croatian: Važno je da kontinuirano uzimate Irbesartan/Hidroklorotiazid Teva sve dok Vam liječnik ne odredi drugačije.
English: For N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) the MAH must introduce the following specifications for the drug substance:
Croatian: Za N-nitrozodimetilamin (NDMA) i N-nitrozodietilamin (NDEA) nositelj odobrenja za stavljanje lijeka u promet mora uvesti sljedeće specifikacije za djelatnu tvar lijeka:
English: Your doctor will normally advise you to stop taking Irbesartan/Hydrochlorothiazide Teva before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Irbesartan/Hydrochlorothiazide Teva.
Croatian: Vaš će Vam liječnik obično preporučiti da prestanete koristiti Irbesartan/Hidroklorotiazid Teva prije nego što zatrudnite ili čim saznate da ste trudni te će Vam savjetovati da uzmete neki drugi lijek umjesto lijeka Irbesartan/Hidroklorotiazid Teva.
English: Increase in dosage of probenecid or sulfinpyrazone may be necessary.
Croatian: Može biti potrebno povećati dozu probenecida ili sulfinpirazona.
English: Twelve percent (12 %) of patients were diabetic, 34 % were hyperlipidemic and the most frequent cardiovascular condition was stable angina pectoris in 3.5 % of the participants.
Croatian: Od šećerne bolesti bolovalo je 12% bolesnika, 34% ih je imalo hiperlipidemiju, a najčešće kardiovaskularno stanje bila je stabilna angina pektoris i to u 3,5% sudionika.
English: The blood pressure lowering effect of irbesartan in combination with hydrochlorothiazide is apparent after the first dose and substantially present within 1-2 weeks, with the maximal effect occurring by 6-8 weeks.
Croatian: Učinak irbesartana u kombinaciji s hidroklorotiazidom na sniženje krvnog tlaka vidljiv je nakon prve doze, značajno prisutan tijekom 1-2 tjedna, a maksimalan učinak nastupa nakon 6-8 tjedana.
English: If hypotension occurs, the patient should be placed in a supine position, with salt and volume replacements given quickly.
Croatian: Ako se pojavi hipotenzija, bolesnika je potrebno položiti u ležeći položaj i brzo mu dati nadomjeske za natrij i volumen.
English: In patients with creatinine clearance < 20 ml/min, the elimination half-life of hydrochlorothiazide was reported to increase to 21 hours.
Croatian: U bolesnika čiji je klirens kreatinina < 20 ml/min, zabilježeno je da se poluvrijeme eliminacije hidroklorotiazida povisi na 21 sat.
English: Peak effects occurred at 3-6 hours.
Croatian: Vrhunac djelovanja nastupa nakon 3-6 sati.
English: The potential toxicity of the irbesartan/hydrochlorothiazide combination after oral administration was evaluated in rats and macaques in studies lasting up to 6 months.
Croatian: Potencijalna toksičnost kombinacije irbesartan/hidroklorotiazid nakon oralne primjene ocijenjena je na štakorima i makaki majmunima, u studijama koje su trajale do 6 mjeseci.
English: • CHMP could not identify cancer screening methods that patients would benefit from, considering the uncertainty of the target organ(s) of NDMA/NDEA toxicity in humans and the risks of measures to monitor patients such as colonoscopy or gastroscopy which may exceed the theoretical excess cancer risk.
Croatian: • CHMP nije mogao utvrditi metode probira na rak od kojih bi bolesnici imali korist s obzirom na nesigurnosti u pogledu toksičnosti tvari NDMA/NDEA za ciljane organe u ljudi te rizika povezanih s mjerama za praćenje pacijenata kao što su kolonoskopija ili gastroskopija koji mogu premašiti teoretski prekomjerni rizik od razvoja raka.
English: Irbesartan is mainly metabolised by CYP2C9 and to a lesser extent by glucuronidation.
Croatian: Irbesartan se uglavnom metabolizira pomoću CYP2C9 i u manjoj mjeri glukuronidacijom.
English: No teratogenic effects were observed in the rat or rabbit.
Croatian: Nisu zabilježeni teratogeni učinci u štakora ili kunića.
English: Pack sizes of 7, 14, 15, 20, 28, 30, 56, 60, 84, 90, 98 and 100 film-coated tablets in non-perforated blisters.
Croatian: Pakiranja od 7, 14, 15, 20, 28, 30, 56, 60, 84, 90, 98 i 100 filmom obloženih tableta u neperforiranim blisterima.
English: Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation.
Croatian: Simptomi uključuju akutnu pojavu smanjene oštrine vida ili boli u oku, a obično se javljaju od nekoliko sati do nekoliko tjedana nakon početka liječenja.
English: For these reasons, N-nitrosamine impurities in pharmaceuticals such as sartans intended for long-term use should be reduced as much as possible.
Croatian: Zbog tih je razloga Nnitrozaminske nečistoće u farmaceutskim proizvodima, kao što su sartani namijenjeni za dugotrajnu primjenu, potrebno smanjiti na najmanju moguću mjeru.
English: During this time period, MAHs and manufacturers are requested to introduce relevant changes to the manufacturing processes of the drug substances, as well as develop appropriate analytical methods while ensuring adequate supply of the market for these essential medicinal products.
Croatian: Tijekom tog vremenskog razdoblja od nositelja odobrenja za stavljanje lijeka u promet i proizvođača zahtijeva se da uvedu relevantne promjene u proizvodne procese djelatnih tvari lijekova i da osmisle odgovarajuće analitičke metode, osiguravajući pritom odgovarajuću opskrbu tržišta tim prijeko potrebnim lijekovima.
English: Irbesartan and hydrochlorothiazide are orally active agents and do not require biotransformation for their activity.
Croatian: Irbesartan i hidroklorotiazid su oralno aktivne tvari i ne zahtijevaju biotransformaciju da bi bile djelotvorne.
English: The mechanism of antihypertensive effect of thiazide diuretics is not fully known.
Croatian: Nije potpuno poznat mehanizam antihipertenzivnog djelovanja tiazidskih diuretika.
English: Psychiatric disorders:
Croatian: Psihijatrijski poremećaji:
English: A full risk assessment for patients previously exposed to NDMA and/or NDEA impurities in sartans, especially valsartan which was found to contain the highest nitrosamine contamination, is not possible as the real extent of exposure of patients is unknown.
Croatian: Nije moguća potpuna procjena rizika u bolesnika koji su prethodno bili izloženi NDMA i/ili NDEA nečistoćama u sartanima, posebno u valsartanu, za koji je utvrđeno da sadrži najveću kontaminaciju nitrozaminom, jer nije poznat stvarni opseg izloženosti bolesnika.
English: If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA.
Croatian: Ako se ocjeni da je ponovna primjena diuretika neophodna, preporučuje se da se izložena područja kože zaštite od Sunca ili umjetnog UVA zračenja.
English: Protect your skin from sun exposure and UV rays while taking Irbesartan/Hydrochlorothiazide Teva
Croatian: Zaštitite svoju kožu od izlaganja suncu i UV zrakama za vrijeme uzimanja Irbesartan/Hidroklorotiazid Teva.
English: There is no evidence that irbesartan would reduce or prevent diuretic-induced hyponatraemia.
Croatian: Nema dokaza da irbesartan smanjuje ili sprječava hiponatrijemiju potaknutu diureticima.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Croatian: Od zdravstvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava: navedenog u Dodatku
English: Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter.
Croatian: Bolesnike treba na odgovarajući način hidrirati, a bubrežnu funkciju treba kontrolirati na početku primjene istodobne terapije te periodički nakon toga.
English: Electrolyte imbalance (including hypokalaemia and hyponatraemia, see section 4.4), hyperuricaemia, glycosuria, hyperglycaemia, increases in cholesterol and triglycerides
Croatian: Poremećaj ravnoteže elektrolita (uključujući hipokalijemiju i hiponatrijemiju, vidjeti dio 4.4.), hiperuricemija, glikozurija, hiperglikemija, porast koncentracije kolesterola i triglicerida
English: If calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) must be prescribed, serum calcium levels should be monitored and calcium dosage adjusted accordingly;
Croatian: Ako se moraju propisati nadomjesci kalcija ili lijekovi koji čuvaju kalcij (primjerice vitamin D), potrebno je nadzirati razinu kalcija u serumu i sukladno tomu prilagoditi dozu kalcija;
English: Following oral or intravenous administration of 14C irbesartan, 80-85% of the circulating plasma radioactivity is attributable to unchanged irbesartan.
Croatian: Nakon oralne ili intravenske primjene 14C irbesartana, 80-85% cirkulirajuće radiokativnosti u plazmi odnosi se na nepromijenjeni irbesartan.
English: An increased risk of non-melanoma skin cancer (NMSC) [basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)] with increasing cumulative dose of hydrochlorothiazide (HCTZ) exposure has been observed in two epidemiological studies based on the Danish National Cancer Registry.
Croatian: Povećani rizik od nemelanomskog raka kože (engl. non-melanoma skin cancer, NMSC) [karcinom bazalnih stanica (engl. basal cell carcinoma, BCC) i karcinom skvamoznih stanica (engl. squamous cell carcinoma, SCC)] kod povećane kumulativne izloženosti hidroklorotiazidu (HCTZ) zabilježen je u dvjema epidemiološkim studijama na temelju danskog Nacionalnog registra za rak.
English: Hydrochlorothiazide crosses the placenta.
Croatian: Hidroklorotiazid prolazi placentu.
English: Rare cases of allergic skin reactions (rash, urticaria), as well as localised swelling of the face, lips and/or tongue have been reported in patients taking irbesartan.
Croatian: Zabilježeni su rijetki slučajevi alergijskih kožnih reakcija (osip, urtikarija), kao i lokalizirano oticanje lica, usana i/ili jezika kod bolesnika koji su uzimali irbesartan.
English: Description of selected adverse reactions
Croatian: Opis izabranih nuspojava
English: The combination of these ingredients has an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone.
Croatian: Kombinacija ovih sastojaka ima povećani antihipertenzivni učinak te izrazitije smanjuje krvni tlak nego svaka komponenta zasebno.
English: Marked hypercalcaemia may be evidence of hidden hyperparathyroidism.
Croatian: Izražena hiperkalcijemija može biti znak prikrivenog hiperparatireoidizma.
English: When clinically appropriate direct change from monotherapy to the fixed combinations may be considered:
Croatian: Kad je klinički primjereno, može se razmotriti izravni prijelaz s monoterapije na fiksnu kombinaciju:
English: When necessary, Irbesartan/HydrochlorothiazideTeva may be administered with another antihypertensive medicinal product (see sections 4.3, 4.4, 4.5 and 5.1).
Croatian: Kada je potrebno, Irbesartan/Hidroklorotiazid Teva može se primjenjivati s drugim antihipertenzivnim lijekom (vidjeti dijelove 4.3,4.4., 4.5 i 5.1).
English: Fertility and reproductive performance were not affected in studies of male and female rats even at oral doses of irbesartan causing some parental toxicity (from 50 to 650 mg/kg/day), including mortality at the highest dose.
Croatian: Nije zabilježen utjecaj na plodnost i reproduktivnu učinkovitost u istraživanjima na mužjacima i ženkama štakora, čak ni pri peroralnim dozama irbesartana koje su uzrokovale određenu toksičnost za životinje (doze od 50 do 650 mg/kg/dan), uključujući mortalitet pri najvišim dozama.
English: Thiazides should be discontinued before carrying out tests for parathyroid function.
Croatian: Potrebno je prekinuti liječenje tiazidima prije obavljanja testova funkcije paratireoidnih žlijezda.
English: Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Croatian: Reakcije preosjetljivosti na hidroklorotiazid mogu se pojaviti u bolesnika koji u povijesti bolesti imaju ili nemaju alergiju ili bronhalnu astmu, no češće su u bolesnika koji ih imaju.
English: • kidney changes, characterized by slight increases in serum urea and creatinine, and hyperplasia/hypertrophy of the juxtaglomerular apparatus, which are a direct consequence of the interaction of irbesartan with the renin-angiotensin system;
Croatian: • promjene funkcije bubrega, karakterizirane blagim porastom razine ureje i kreatinina u serumu kao i hiperplazijom/hipertrofijom jukstaglomerularnog aparata, što je izravna posljedica interakcije irbesartana s renin-angiotenzinskim sustavom;
English: This fixed dose combination is indicated in adult patients whose blood pressure is not adequately controlled on irbesartan or hydrochlorothiazide alone (see section 5.1).
Croatian: Ova fiksna kombinacija indicirana je za liječenje odraslih bolesnika čiji se krvni tlak ne može na odgovarajući način kontrolirati samo irbesartanom ili hidroklorotiazidom (vidjeti dio 5.1).
English: Studies in animals indicate that the radiolabelled irbesartan is detected in rat and rabbit foetuses.
Croatian: Istraživanja na životinjama pokazuju da je radioaktivno označeni irbesartan uočen u fetusima štakora i kunića.
English: The key issue of this referral concerns the detection of N-nitrosamine (esp. NDMA and/or NDEA) contaminations in sartans, the resulting potential long-term risk to patients and measures to minimise as much as possible these contaminations.
Croatian: Ključno pitanje ovog postupka upućivanja odnosi se na otkrivanje kontaminacija N-nitrozaminom (osobito tvarima NDMA i/ili NDEA) u sartanima, potencijalni dugoročni rizik za bolesnike koji proizlazi iz tih kontaminacija te mjere za njihovo smanjivanje na najmanju moguću mjeru.
English: Metabolism and nutrition disorders:
Croatian: Poremećaji metabolizma i prehrane:
English: In comparison to the daily intake levels calculated based on ICH M7(R1) using non-clinical toxicology, it is possible to generate additional safety factors ranging from 2.73 - 27.3 for NDMA and 10.0 - 100 for NDEA, by defining 0.03 ppm as the common technical target limit for NDEA and NDMA in tetrazole sartan APIs.
Croatian: U usporedbi s razinama dnevnog unosa koje su s pomoću nekliničke toksikologije izračunate na temelju Smjernica ICH M7(R1) mogu se dobiti dodatni sigurnosni čimbenici u rasponu od 2,7327,3 za NDMA i 10,0 - 100 za NDEA, na osnovi utvrđivanja 0,03 ppm kao zajedničkog tehničkog ciljnog ograničenja za NDEA i NDMA u aktivnim farmaceutskim sastojcima sartana s tetrazolnim prstenom.
English: Serum electrolytes and creatinine should be monitored frequently.
Croatian: Često je potrebno mjeriti razinu elektrolita i kreatinina u serumu.
English: A cumulative dose-response relationship was demonstrated with an adjusted OR 2.1 (95% CI: 1.7-2.6) increasing to OR 3.9 (3.0-4.9) for high use (~25,000 mg) and OR 7.7 (5.7-10.5) for the highest cumulative dose (~100,000 mg) (see also section 4.4).
Croatian: Povezanost odgovora i kumulativne doze dokazana je s prilagođenim OR 2,1 (95% CI: 1,7-2,6) s povećanjem na OR 3,9 (3,0-4,9) za veliku primjenu hidroklorotiazida (~25 000 mg) i OR 7,7 (5,7-10,5) za najvišu kumulativnu dozu (~100 000 mg) (vidjeti i dio 4.4).
English: It is unknown whether irbesartan or its metabolites are excreted in human milk.
Croatian: Nije poznato izlučuje li se irbesartan ili njegovi metaboliti u majčino mlijeko u ljudi.
English: Available pharmacodynamic/toxicological data in rats have shown excretion of irbesartan or its metabolites in milk (for details see 5.3).
Croatian: Raspoloživi farmakodinamički/toksikološki podaci za štakore pokazuju da se irbesartan i njegovi metaboliti izlučuju u mlijeko (za pojedinosti vidjeti dio 5.3).
English: Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts.
Croatian: Tiazidi djeluju na mehanizam reapsorpcije elektrolita u bubrežnim tubulima, izravno pojačavajući izlučivanje natrija i klorida u približno jednakim količinama.
English: When driving vehicles or operating machines, it should be taken into account that occasionally dizziness or weariness may occur during treatment of hypertension.
Croatian: Prilikom upravljanja vozilima i strojevima potrebno je uzeti u obzir da se tijekom liječenja hipertenzije mogu povremeno pojaviti omaglica i umor.
English: Cases of photosensitivity reactions have been reported with thiazides diuretics (see section 4.8).
Croatian: Prijavljeni su slučajevi reakcija fotoosjetljivosti prilikom primjene tiazidskih diuretika (vidjeti dio 4.8.).
English: Hydrochlorothiazide should not be used for gestational oedema, gestational hypertension or preeclampsia due to the risk of decreased plasma volume and placental hypoperfusion, without a beneficial effect on the course of the disease.
Croatian: Hidroklorotiazid se ne smije koristiti za liječenje gestacijskog edema, gestacijske hipertenzije ili preeklampsije zbog rizika od smanjenog plazmatskog volumena i placentarne hipoperfuzije, bez pozitivnog učinka na tijek bolesti.
English: Irbesartan is excreted in the milk of lactating rats.
Croatian: Irbesartan se izlučuje u mlijeko štakorica u laktaciji.
English: Angiotensin-II is a substance produced in the body that binds to receptors in blood vessels causing them to tighten.
Croatian: Angiotenzin II je sastojak koji stvara tijelo i koji se veže na receptore u krvnim žilama te uzrokuje njihovo sužavanje.
English: When angiotensin II antagonists are administered simultaneously with non-steroidal anti-inflammatory drugs (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Croatian: Kad se antagonisti angiotenzina II primjenjuju istodobno s nesteroidnim protuupalnim lijekovima (npr. selektivnim inhibitorima COX2, acetilsalicilatnom kiselinom (> 3 g/dan) i neselektivnim nesteroidnim protuupalnim lijekovima), može doći do slabljenja antihipertenzivnog učinka.
English: Should NDMA and NDEA be detected in parallel in an API batch, this should lead to rejection of the respective batch, considering that a combined contamination would translate into a combined risk, which may be higher than one additional case of cancer in 100.000 individuals.
Croatian: Ako se otkrije da serija aktivnih farmaceutskih sastojaka istodobno sadržava tvari NDMA i NDEA, potrebno je odbaciti tu seriju s obzirom na to da bi kombinirana kontaminacija podrazumijevala kombinirani rizik, koji može biti veći od jednog dodatnog slučaja raka na 100 000 osoba.
English: Thiazides may reduce the renal excretion of cytotoxic medicinal products (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Croatian: Tiazidi mogu smanjiti bubrežnu ekskreciju citotoksičnih lijekova (primjerice ciklofosfamida, metotreksata) i pojačati njihove mijelosupresivne učinke.
English: The following changes, observed in rats and macaques receiving the irbesartan/hydrochlorothiazide combination at 10/10 and 90/90 mg/kg/day, were also seen with one of the two medicinal products alone and/or were secondary to decreases in blood pressure (no significant toxicologic interactions were observed):
Croatian: Sljedeće promjene, zabilježene kod štakora i makaki majmuna, koji su dobivali kombinaciju irbesartan/hidroklorotiazid u dozama od 10/10 i 90/90 mg/kg/dan, također su uočene i kod pojedinačne primjene ovih lijekova i/ili su bile sekundarne sniženju krvnog tlaka (nisu zabilježene značajne toksikološke interakcije):<
English: Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnaesemia.
Croatian: Tiazidi povećavaju izlučivanje magnezija urinom, što može dovesti do hipomagnezijemije.
English: Adverse Reactions In Placebo-Controlled Trials and Spontaneous Reports Investigations:
Croatian: Nuspojave prikupljene u placebom kontroliranim studijama i spontanim prijavljivanjem