FrancophonIA/ELRC3.0 huggingface dataset:
English: Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class.
Maltese: Robenacoxib huwa mediċina anti-infjammatorja mhux sterojdi (NSAID) tal-klassi ta' coxib.
English: COX-1 is the constitutive form of the enzyme and has protective functions, e.g. in the gastrointestinal tract and kidneys.
Maltese: COX-1 huwa l-forma kostituttiva tal-enzim u għandu funzjonijiet protettivi, eż. fil-passaġġi gastrointestinali u fil-kliewi.
English: NAME OF THE VETERINARY MEDICINAL PRODUCT Onsior 6 mg tablets for cats
Maltese: VETERINARJU Onsior 6 mg pilloli għal qtates
English: 10 mg tablet: BE 20 mg tablet: CD 40 mg tablet: BCK
Maltese: Pilloli ta' 5 mg: AK Pilloli ta' 10 mg: BE Pilloli ta' 20 mg: CD Pilloli ta' 40 mg: BCK
English: Robenacoxib had analgesic and anti-inflammatory actions in an inflammation model in dogs with single oral doses ranging from 0.5 to 8 mg/kg, with an ID50 of 0.8 mg/kg and a rapid onset of action (0.5 h).
Maltese: Robenacoxib kellu azzjonijiet analġesiċi u anti-infjammatorji f'mudell ta' infjammazzjoni fi klieb b'doża waħda orali li tvarja minn 0.5 sa 8 mg/kg, b'ID50 ta' 0.8 mg/kg u b'bidu rapidu ta' azzjoni (0.5 h).
English: Pharmacotherapeutic group: Anti-inflammatory and antirheumatic products, non-steroids, coxibs.
Maltese: Prodotti anti-infjammatorji u anti-rewmatiċi, mhux sterodji, coxibs.
English: Detailed information on this product is available on the website of the European Medicines Agency (http://www.ema.europa.eu/).
Maltese: Ewropea dwar il-Mediċini http://www.ema.europa.eu/.
English: At the recommended dosage (2 mg/kg), analgesic, anti-inflammatory and anti-pyretic effects were demonstrated in an inflammation model, and in clinical trials, robenacoxib reduced pain and inflammation in cats undergoing orthopaedic or soft tissue surgery.
Maltese: Fid-dożaġġi rakkomandati (2 mg/kg), intwerew effetti analġesiċi, antiinfjammatorji u anti-piretiċi f'mudell ta' infjammazzjoni u fi provi kliniċi, robenacoxib naqqas l-uġigħ u l-infjammazzjoni fi qtates li kienu għaddejjin minn kirurġija ortopedika jew tat-tessut l-artab.
English: At dosages ranging from 0.25 to 4 mg/kg, robenacoxib had analgesic, anti-inflammatory and anti-pyretic effects in an inflammation model with a rapid onset of action (1 h).
Maltese: aġġi li jvarjaw minn 0.25 sa 4 mg/kg, robenacoxib kellu effetti analġesiċi, anti-infjammatorji u anti-piretiċi f'mudell ta' infjammazzjoni b'bidu rapidu ta' azzjoni (siegħa).
English: Imprints
Maltese: MANIFATTURI
English: Differences between robenacoxib and placebo were significant (P<0.05) for the client specific outcome measures, but did not reach significance (P=0.07) for the feline musculoskeletal pain index.
Maltese: Differenzi bejn robenacoxib u placebo kienu sinifikanti (P<0.05) għall-miżuri ta' eżitu speċifiċi għallklijent, pero ma kienux sinifikanti (P=0.07) għall-indiċi tal-uġigh fil-qtates.
English: The cyclooxygenase enzyme (COX) is present in two forms.
Maltese: L-enzim cyclooxygenase (COX) huwa preżenti f'żewġ forom.
English: In dogs, robenacoxib was in vitro approximately 140 fold selective for COX-2 (IC50 0.04 μM) as compared to COX-1 (IC50 7.9 μM).
Maltese: Fil-klieb, robenacoxib kien, in vitro, bejn wieħed u ieħor 140 darba selettiv għal COX-2 (IC50 0.04 μM) meta mqabbel ma' COX-1 (IC50 7.9 μM).
English: The interchangeable use of Onsior tablets and Onsior solution for injection in 4-months old cats at overdoses of up to 3 times the maximum recommended dose (2.4 mg, 4.8 mg, 7.2 mg robenacoxib/kg orally and 2.0 mg, 4.0 mg and 6.0 mg robenacoxib/kg subcutaneously) resulted in a dose-dependent increase of sporadic oedema at the injection site and minimal to mild subacute/chronic inflammation of the subcutaneous tissue.
Maltese: 4 xhur f'dożi eċċessivi għal sa 3 darbiet tad-doża massima rakkomandata (2.4 mg, 4.8 mg, 7.2 mg robenacoxib/kg orali u 2.0 mg, 4.0 mg u 6.0 mg robenacoxib/kg taħt il-ġilda), irriżulta f'żieda li tiddependi mid-doża ta' edema sporadika fis-sit tal-injezzjoni, u infjammazzjoni subakuta/kronika minn minima sa ħafifa tat-tessut ta' taħt il-ġilda.
English: In the high dose group kidney weights were decreased and sporadically associated with renal tubular degeneration/ regeneration but not correlated with evidence of renal dysfunction on clinical pathology parameters.
Maltese: deġenerazzjoni/riġenerazzjoni tubulari tal-kliewi, imma mhux korrelati b'evidenza ta' disfunzjoni tal kliewi fuq parametri patoloġiċi kliniċi.
English: Acute musculoskeletal disorders: treat for up to 6 days.
Maltese: Għal disturbi muskuloskeletali akuti: ikkura għal mhux aktar minn 6 ijiem.
English: PHARMACEUTICAL FORM Solution for injection.
Maltese: GĦAMLA FARMAĊEWTIKA Soluzzjoni għal injezzjoni.
English: In vivo, robenacoxib solution for injection produced marked inhibition of COX-2 activity and had no effect on COX-1 activity.
Maltese: In vivo, soluzzjoni ta' Robenacoxib għal injezzjoni pproduċiet inibizzjoni sinifikanti ta' attività COX-2 u ma kellha ebda effett fuq l-attività ta' COX-1.
English: EU/2/08/089/004-019 EU/2/08/089/022-029
Maltese: EU/2/08/089/022-029
English: The cyclooxygenase 1 enzyme (COX-1) which has protective functions, e.g. in the digestive tract and kidneys, is not inhibited by robenacoxib.
Maltese: L-enzima cyclooxygenase 1 (COX-1) li għandha funzjonijiet protettivi, eż. fl-apparat diġestiv u l-kliewi, mhijiex inibita minn robenacoxib.
English: Co-administration of robenacoxib tablets with one third of the daily food ration produced no change in Tmax (0.5 h), Cmax (1,201 ng/ml) or AUC (1383 ng·h/ml).
Maltese: L-għoti fl-istess ħin ta' pilloli robenacoxib ma' terz tal-porzjon ta' ikel ta' kuljum ma pproduċa ebda bidla f'Tmax (0.5 h), Cmax (1201 ng/ml) jew AUC (1383 ng.h/ml).
English: A clinical response is normally seen within 3-6 weeks.
Maltese: Rispons kliniku normalment jidher f'bejn 3 u 6 ġimgħat.
English: 4.11 Withdrawal period(s) Not applicable.
Maltese: 4.11 Perjodu(i) ta' tiżmim Mhux applikabbli.
English: NAME OF THE VETERINARY MEDICINAL PRODUCT Onsior 20 mg/ml solution for injection for cats and dogs Robenacoxib
Maltese: VETERINARJU Onsior 20 mg/ml soluzzjoni għal injezzjoni għal klieb u qtates
English: EU/2/08/089/001-003 EU/2/08/089/021
Maltese: EU/2/08/089/001-003
English: Accumulation of metabolites has not been tested.
Maltese: Akkumulazzjoni ta' metaboliti ma ġietx ittestjata.
English: COX-2 is the inducible form of the enzyme which is responsible for the production of mediators including PGE2 which induce pain, inflammation or fever.
Maltese: COX-2 huwa l-forma induċibbli tal-enzim u huwa responsabbli għall-produzzjoni ta' medjaturi inkluż PGE2 li jinduċu uġigħ, infjammazzjoni jew deni.
English: Onsior tablets for cats are available in cardboard boxes containing 6 x 1, 12 x 1, 30 x 1 or 60 x 1 tablets in Alu/Alu perforated unit dose blisters.. Not all pack sizes may be marketed.
Maltese: Pilloli Onsior għall-qtates huma disponibbli f'kaxxi tal-kartun li fihom 6 x 1, 12 x 1, 30 x 1 jew 60 x 1 pillola f'folji perforati tal-Alu/Alu ta' doża unika.
English: In clinical trials in cats, robenacoxib tablets reduced pain and inflammation associated with acute musculo-skeletal disorders and reduced the need for rescue treatment when given as premedication in case of orthopaedic surgery, in combination with opioids.
Maltese: Fi provi kliniċi fil-qtates, il-pilloli robenacoxib naqqsu l-uġigħ u l-infjammazzjoni assoċjati ma' disturbi akuti muskuloskeletali u naqqsu l-ħtieġa għal kura ta' salvataġġ meta mogħtija bħala premedikazzjoni fil-każ ta' kirurġija ortopedika, f'kombinazzjoni mal-opjojdi.
English: Onsior 20 mg tablets for dogs:
Maltese: Onsior 20 mg pilloli għal klieb:
English: Reversible inflammation at the injection site was noted in all groups (including controls) and was more severe in the 6 and 20 mg/kg dose groups.
Maltese: Infjammazzjoni riversibbli fis-sit tal-injezzjoni ġiet innotata filgruppi kollha (inkluż fil-kontrolli) u kienet aktar severa fil-gruppi tad-doża ta' 6 u 20 mg/kg.
English: EXPIRY DATE EXP {month/year} Once broached, use by …
Maltese: Ladarba miftuħ, uża sa ...
English: In a clinical study, 10 of 35 CMSD cats were assessed to be significantly more active when treated with robenacoxib for three weeks compared to these same cats when they received a placebo treatment.
Maltese: Fi studju kliniku, 10 minn 35 qtates CMSD kienu evalwati li kienu aktar attivi b'mod sinifikanti meta trattati b'robenacoxib għall-tlett ġimgħat meta mqabbel mal-istess qtates li rċivew trattament bi placebo.
English: Administer subcutaneously to cats or dogs approximately 30 minutes before the start of surgery, for example around the time of induction of general anaesthesia, at a dose of 1 ml per 10 kg of body weight (2 mg/kg).
Maltese: U METODU TA' AMMINISTRAZZJONI Agħti s-soluzzjoni taħt il-ġilda lil qtates jew klieb madwar 30 minuta qabel il-bidu tal-kirurġija, per eżempju madwar il-ħin ta' l-induzzjoni ta' anastesija ġenerali, f'doża ta' 1 ml għal kull 10 kg ta' piż tal-ġisem (2 mg/kg).
English: EU/2/08/089/001 (6 x 1 tablets) EU/2/08/089/002 (12 x 1 tablets) EU/2/08/089/021 (30 x 1 tablets) EU/2/08/089/003 (60 x 1 tablets)
Maltese: EU/2/08/089/001 (6 x 1 pilloli) EU/2/08/089/002 (12 x 1 pillola) EU/2/08/089/021 (30 x 1 pillola) EU/2/08/089/003 (60 x 1 pillola)
English: After a dosage of 2 mg/kg a Tmax of 1 h (cats and dogs), a Cmax of 1,464 ng/ml (cats) and 615 ng/ml (dogs), and an AUC of 3,128 ng·h/ml (cats) and 2,180 ng·h/ml (dogs) is obtained.
Maltese: ng/ml (qtates) u 615 ng/ml (klieb), u AUC ta' 3,128 ng.h/ml (qtates) u 2,180 ng.h/ml (klieb).
English: In healthy young cats aged 7- 8 months, oral robenacoxib (Onsior tablets) administered at overdoses of up to 5 times the maximum recommended dose (2.4 mg, 7.2 mg, 12 mg robenacoxib/kg bodyweight ) for 6 months was well tolerated.
Maltese: Fi qtates żgħar u f'saħħithom li kellhom 7-8 xhur, robenacoxib orali (pilloli Onsior) mogħti f'dożi eċċessivi ta' sa 5 darbiet tad-doża massima rakkomandata (2.4 mg, 7.2 mg, 12 mg robenacoxib/kg ta' piż tal-ġisem) għal 6 xhur, ġie ttollerat tajjeb.
English: The recommended dose of robenacoxib is 1 mg/kg body weight with a range 1-2.4 mg/kg.
Maltese: Id-doża rakkomandata ta' robenacoxib hija 1 mg/kg piż tal-ġisem b'medda ta' 1-2.4 mg/kg.
English: 6 mg. For the full list of excipients, see section 6.1.
Maltese: Għal-lista sħiħa ta' sustanzi mhux attivi ara sezzjoni 6.1.
English: Onsior 40 mg tablets for dogs:
Maltese: Onsior 40 mg pilloli għal klieb:
English: Onsior 10 mg tablets for dogs:
Maltese: Onsior 10 mg pilloli għal klieb:
English: Onsior 5 mg tablets for dogs:
Maltese: Onsior 5 mg pilloli għal klieb
English: Co-administration of robenacoxib non-flavoured tablets with food produced no delay in Tmax, but slightly lower values for Cmax (832 ng/ml) and AUC (782 ng·h/ml).
Maltese: L-għoti fl-istess ħin ta' pilloli mingħajr togħma robenacoxib mal-ikel ma pproduċa ebda dewmien f'Tmax, iżda valuri xi ftit iktar baxxi għal Cmax (832 ng/ml) u AUC (782 ng.h/ml).
English: Orthopaedic surgery: Give as a single oral treatment prior to orthopaedic surgery.
Maltese: Agħti bħala trattament orali wieħed qabel kirurġija ortopedika.
English: Concomitant treatment with medicines displaying action on renal flow, e.g. diuretics or angiotensin converting enzyme (ACE) inhibitors, should be subject to clinical monitoring.
Maltese: It-trattament flimkien ma' mediċini li jimmanifestaw azzjoni fuq il-fluss renali, eż. dijuretiċi jew inibituri ta' enzimi li jikkonvertu l-angiotensin (ACE), għandu jkun suġġett għal monitoraġġ kliniku.
English: 5 mg tablet:
Maltese: Kull pillola fiha:
English: COX-2 activity and had no effect on COX-1 activity in dogs at oral doses ranging from 0.5 to 4 mg/kg.
Maltese: Robenacoxib ipproduċa inibizzjoni sinjifikanti tal-attività ta' COX-2 u ma kellu ebda effett fuq l-attività ta' COX-1 fi klieb b'dożi orali li jvarjaw minn 0.5 sa 4 mg/kg.
English: Robenacoxib is extensively metabolised by the liver in dogs.
Maltese: Robenacoxib huwa metabolizzat b'mod estensiv mill-fwied fil-klieb.
English: Onsior 5 mg tablets for dogs Onsior 10 mg tablets for dogs Onsior 20 mg tablets for dogs Onsior 40 mg tablets for dogs
Maltese: Onsior 5 mg pilloli għall-klieb Onsior 10 mg pilloli għal klieb Onsior 20 mg pilloli għal klieb Onsior 40 mg pilloli għal klieb
English: Cardboard box containing 7, 14, 28 or 70 tablets in Alu/Alu blisters, 30 x 1 tablets in Alu/Alu perforated unit dose blisters or 60 x 1 tablets in Alu/Alu perforated unit dose blisters.
Maltese: In-natura u l-għamla tal-ippakkjar li jmiss mal-prodott Kaxxa tal-kartun li fiha 7, 14, 28 jew 70 pilloli f'folji tal-Alu/Alu, 30 x 1 pillola f'folji perforati tal
English: Robenacoxib is excreted predominantly via the biliary route (∼65%) and the remainder via the kidneys.
Maltese: Robenacoxib jitneħħa predominantament permezz tar-rotta biljari (∼65 %) u l-bqija permezz tal-kliewi.
English: Robenacoxib is excreted predominantly via the biliary route in cats (∼70%) and dogs (∼65%) and the remainder via the kidneys.
Maltese: Robenacoxib jitneħħa predominantament permezz tar-rotta biljari fil-qtates (∼70 %) u fil-klieb (∼65
English: In clinical trials at the recommended dose (2 mg/kg), robenacoxib reduced pain and inflammation in dogs undergoing orthopaedic or soft tissue surgery.
Maltese: Fi provi kliniċi, fid-do¿a rakkomandata (2 mg/kg), robenacoxib naqqas l-uġigħ u l-infjammazzjoni u fi klieb li kienu qegħdin jagħmlu kirurġija ortopedika jew tat-tessut artab.
English: DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION The recommended dose of robenacoxib is 1 mg/kg body weight with a range 1-2 mg/kg.
Maltese: U METODU TA' AMMINISTRAZZJONI Id-doża rakkomandata ta' robenacoxib hija 1 mg/kg ta' piż tal-ġisem b'medda ta' 1-2 mg/kg.
English: EU/2/08/089/008 (7 tablets) EU/2/08/089/009 (14 tablets) EU/2/08/089/010 (28 tablets) EU/2/08/089/011 (70 tablets) EU/2/08/089/024 (30 x 1 tablets) EU/2/08/089/025 (60 x 1 tablets)
Maltese: EU/2/08/089/008 (7 pilloli) EU/2/08/089/009 (14 pilloli) EU/2/08/089/010 (28 pilloli) EU/2/08/089/011 (70 pilloli) EU/2/08/089/024 (30 x 1 pillola) EU/2/08/089/025 (60 x 1 pillola)
English: For the reduction of moderate pain and inflammation associated with orthopaedic surgery in cats.
Maltese: Għat-tnaqqis ta' uġigħ moderat u ta' infjammazzjoni assoċjati ma' kirurġija ortopedika fil-qtates.
English: NATURE/TYPE: Blister foil
Maltese: GĦAMLA /TIP:
English: Each tablet contains 5 mg Robenacoxib Each tablet contains 10 mg Robenacoxib Each tablet contains 20 mg Robenacoxib Each tablet contains 40 mg Robenacoxib
Maltese: Kull pillola fiha 5 mg Robenacoxib Kull pillola fiha 10 mg Robenacoxib Kull pillola fiha 20 mg Robenacoxib Kull pillola fiha 40 mg Robenacoxib
English: The pharmacokinetics of robenacoxib do not differ between male and female dogs, and are linear over the range 0.5-8 mg/kg.
Maltese: Il-farmakokinetika ta' robenacoxib ma tagħmilx differenza bejn klieb irġiel u klieb nisa, u huma lineari fuq il-medda ta' 0.5-8 mg/kg.
English: PACKAGE LEAFLET: Onsior 6 mg tablets for cats
Maltese: Onsior 6 mg pilloli għall-qtates
English: In healthy cats treated with or without the diuretic furosemide, concomitant administration of Onsior with the ACE inhibitor benazepril for 7 days was not associated with any negative effects on plasma aldosterone concentrations, plasma renin activity or glomerular filtration rate.
Maltese: Fi qtates f'saħħithom ittrattati bi jew mingħajr furosemide dijuretiku, l-għoti fl-istess ħin ta' Onsior ma' inibitur ACE ta' benazepril għal 7 ijiem, ma kienx assoċjat ma' kwalunkwe effetti negattivi fuq konċentrazzjoni ta' aldosterone fil-plażma, attivita tar-renin fil-plażma jew ir-rata ta' filtrazzjoni glomerulari.
English: In two clinical trials in (mainly indoor) cats with chronic musculo-skeletal disorder, robenacoxib increased the activity and improved subjective scores of activity, behaviour, quality of life, temperament and happiness of the cats.
Maltese: F'żewġ provi kliniċi fi qtates (prinċipalment ta' ġewwa) b'disturb muskoluskeletriku kroniku, robenacoxib żied l-attività u tejjeb il-punteġġi suġġettivi tal-attività, l-imġiba, il-kwalità tal-ħajja, it-temperament u l-ferħ tal-qtates.
English: In overdose studies conducted in cats, there was a dose-dependent increase in the QT interval.
Maltese: Fi studji ta' doża eċċessiva fil-qtates, kien hemm żieda fl-intervall QT dipendenti fuq id-doża.
English: In healthy young dogs aged 6 months, once daily subcutaneous administration of robenacoxib at doses of 2 (recommended therapeutic dose; RTD), 6 (3 times RTD), and 20 mg/kg (10 times RTD) for 9 administrations over a 5 week period (3 cycles of 3 consecutive once daily injections) did not produce any signs of toxicity, including gastrointestinal, kidney or liver toxicity and had no effect on bleeding time.
Maltese: DTR), 6 (3 darbiet DTR), u 20 mg/kg (10 darbiet DTR) għal 9 għotjiet fuq perjodu ta' 5 ġimgħat (3 ċikli ta' 3 injezzjonijiet konsekuttivi ta' darba kuljum) ma taw ebda sinjal ta' tossiċità, inkluż ebda tossiċità gastrointestinali, tal-kliewi jew tal-fwied u ma kellu ebda effett fuq il-ħin ta' ħruġ ta' demm.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Maltese: - komuni (aktar minn annimal 1 iżda inqas minn 10 annimali minn kull 100 ittrattat) - mhux komuni (aktar minn annimal 1 iżda inqas minn 10 annimali minn kull 1,000 ittrattat) - rari (aktar minn annimal 1 iżda inqas minn 10 annimali minn kull 10,000 ittrattat) - rari ħafna (inqas minn annimal 1 minn kull 10,000 ittrattat, inkluż rapporti iżolati).
English: Vomiting was very commonly reported, and anorexia, diarrhoea, lethargy and inappropriate defecation were commonly reported in field studies with treatment up to 3 months in cats with chronic musculo-skeletal disorder, with similar frequencies in the Onsior and placebo treated cats.
Maltese: Ir-rimettar ġie rrappurtat bħala li kien komuni ħafna, u l-anoressija, dijarea, letarġija u ppurgar mhux kif suppost ġew irrappurtati b'mod komuni fl-istudji fil-kamp bi trattament għal sa 3 xhur fi qtates b'disturb muskoluskeletriku kroniku, bi frekwenzi simili fi qtates trattati b'Onsior u bi plaċebo.
English: Symptomatic, supportive therapy is recommended consisting of administration of gastrointestinal protective agents and infusion of isotonic saline.
Maltese: Hija rakkomandata terapija sintomatika, ta' appoġġ li tikkonsisti mill-għoti ta' sustanzi protettivi gastrointestinali u infużjoni ta' soluzzjoni bil-melħ isotonika.
English: Tablets are round, beige to brown, non-divisible and with imprints “NA” on one side and “AK” on the other side.
Maltese: Pilloli tondi, kannella jagħti fl-isfar għal kannella, b'tinqixa “NA” fuq naħa u “AK” fuq in-naħa l-oħra.
English: For the treatment of pain and inflammation associated with acute or chronic musculoskeletal disorders in cats.
Maltese: Għat-trattament ta' uġigħ u infjammazzjoni assoċjati ma' disturbi muskulo-skeletali akuti u kroniċi fil qtates.
English: In healthy young cats aged 7- 8 months, oral robenacoxib administered at overdoses of up to 5 times the maximum recommended dose (2.4 mg, 7.2 mg, 12 mg robenacoxib/kg bodyweight) for 6 months was well tolerated.
Maltese: Fi qtates żgħar u f'saħħithom li kellhom 7-8 xhur, robenacoxib orali mogħti f'dożi eċċessivi ta' sa 5 darbiet tad-doża massima rakkomandata (2.4 mg, 7.2 mg, 12 mg robenacoxib/kg ta' piż tal-ġisem) għal 6 xhur, ġie ttollerat tajjeb.
English: Cardboard box containing 6 x 1, 12 x 1, 30 x 1 or 60 x 1 tablets in Alu/Alu perforated unit dose blisters.
Maltese: In-natura u l-għamla tal-ippakkjar li jmiss mal-prodott Kaxxa tal-kartun li fiha 6 x 1, 12 x 1, 30 x 1 jew 60 x 1 pillola f'folji perforati tal-Alu/Alu ta' doża unika.
English: Repeated oral administration of robenacoxib to dogs at dosages of 2-10 mg/kg for 6 months produced no change in the blood profile, with neither accumulation of robenacoxib nor enzyme induction.
Maltese: Għoti orali ripetut ta' robenacoxib lil klieb f'dożaġġi ta' 2-10 mg/kg għal 6 xhur ma pproduċa ebda bidla fil-profil tad-demm, la b'akkumulazzjoni ta' robenacoxib u lanqas b'induzzjoni tal-enzimi.
English: In cats, using an in vitro whole blood assay, robenacoxib was approximately 500 fold selective for COX-2 (IC50 0.058 μM) as compared to COX-1 (IC50 28.9 μM).
Maltese: Fl-assaġġi ta' demm sħiħ, in vitro fil-qtates, is-selettività ta' robenacoxib kienet madwar 500 darba aktar għal COX-2 (IC50 0.058 μM) meta mqabbla ma' COX-1 (IC50 28.9 μM).
English: 68330 Huningue
Maltese: 26 Rue de la Chapelle F-68330 Huningue
English: Mild and transient diarrhoea, soft faeces or vomiting were commonly reported in clinical trials with treatment up to 6 days.
Maltese: Dijarea ħafifa u temporanja, ippurgar maħlul jew rimettar kienu spiss rrapportati fil-provi kliniċi bi trattament għal sa 6 ijiem.
English: STATEMENT OF ACTIVE SUBSTANCES Each tablet contains 6 mg Robenacoxib
Maltese: Kull pillola fiha 6 mg Robenacoxib
English: In clinical trials in cats this product reduced pain and inflammation associated with acute musculo-skeletal disorders and reduced the need for rescue treatment when given as premedication in case of orthopaedic surgery, in combination with opioids.
Maltese: Fi provi kliniċi fil-qtates, dan il-prodott naqqas l-uġigħ u l-infjammazzjoni assoċjati ma' disturbi muskuloskeletali akuti u naqqas il-ħtieġa għal kura ta' salvataġġ meta mogħti bħala premedikazzjoni fil-każ ta' kirurġija ortopedika, f'kombinazzjoni malopjojdi.
English: The recommended dose of robenacoxib is 1 mg/kg body weight with a range 1-2 mg/kg.
Maltese: Id-doża rakkomandata ta' robenacoxib hija 1 mg/kg piż tal-ġisem b'medda ta' 1-2 mg/kg.
English: After subcutaneous administration, the terminal half-life from blood was 1.1 h in cats and 1.2 h in dogs.
Maltese: Wara għoti taħt il-ġilda, il half-life terminali mid-demm kien ta' 1.1 siegħa fil-qtates u 1.2 siegħa fil-klieb.
English: In pregnant women, particularly near term pregnant women, prolonged dermal exposure increases the risk for premature closure of the ductus arteriosus in the foetus.
Maltese: F'nisa tqal, partikolarment dawk in-nisa tqal li jkunu waslu biex iweldu, kuntatt fit-tul mal-ġilda jżid ir-riskju ta' għeluq prematur tad-ductus arteriosus fil-fetu.
English: After intravenous administration robenacoxib was rapidly cleared from blood (CL of 0.44 L/kg/h in cats and 0.81 L/kg/h in dogs) with an elimination t1/2 of 1.1 h in cats and 0.8 h in dogs.
Maltese: L/kg/h fil-qtates u 0.81 L/kg/h fil-klieb) b'eliminazzjoni t1/2 ta' 1.1 h fil-qtates u ta' 0.8 h fil-klieb.
English: Do not use concomitantly with corticosteroids or other non-steroidal anti-inflammatory drugs (NSAIDs).
Maltese: Tużax fl-istess ħin ma' kortikosterojdi jew ma' mediċini anti-infjammatorji mhux sterojdi (NSAIDs) oħrajn.
English: In healthy young cats aged 10 months, once daily subcutaneous administration of robenacoxib at doses of 4 mg/kg (twice RTD) for 2 consecutive days and 10 mg/kg (5 times RTD) for 3 consecutive days did not produce any signs of toxicity, including signs of gastrointestinal, kidney or liver toxicity and had no effect on bleeding time.
Maltese: Fi qtates żgħar f'saħħithom ta' 10 xhur, għoti taħt il-ġilda ta' robenacoxib darba kuljum f'dożi ta' 4 mg/kg (darbtejn DTR) għal jumejn konsekuttivi u 10 mg/kg (5 darbiet DTR) għal 3 ijiem konsekuttivi ma pproduċew ebda sinjal ta' tossiċità, inkluż sinjali ta' tossiċità gastrointestinali, tal-kliewi jew talfwied u ma kellu ebda effett fuq il-ħin ta' ħruġ ta' demm.
English: As anaesthetics may affect renal perfusion, the use of parenteral fluid therapy during surgery should be considered to decrease potential renal complications when using NSAIDs peri-operatively.
Maltese: Billi l-anestetiċi jistgħu jaffettwaw il-perfużjoni renali, għandu jiġi kkunsidrat l-użu ta' terapija fluwida parenterali waqt il-kirurġija sabiex jitnaqqsu l-kumplikazzjonijiet potenzjali fil-kliewi meta jintużaw NSAIDs b'mod peri-operattiv.