FrancophonIA/ELRC3.0 huggingface dataset:
English: • increased levels of blood albumin
Slovenian: • zvišana vrednost albuminov v krvi
English: • increase in enzymes due to muscle breakdown (creatine phosphokinase)
Slovenian: • zvišana vrednost encima, ki se sprošča pri razgradnji mišic (encima kreatin kinaze)
English: Based on model estimate, elderly (≥65 years) patients had approximately 41% higher plasma eltrombopag AUC(0-) as compared to younger patients (see section 4.2).
Slovenian: Na osnovi ocene modela, so bile vrednosti AUC(0-) eltrombopaga v plazmi za 41 % večje pri starejših bolnikih (≥65 let) kot pri mlajših bolnikih (glejte poglavje 4.2).
English: Clinical haematology and liver tests should be monitored regularly throughout therapy with eltrombopag and the dosage regimen of eltrombopag modified based on platelet counts as outlined in Table 3.
Slovenian: Ves čas zdravljenja z eltrombopagom je treba redno spremljati rezultate hematoloških preiskav in testov jetrne funkcije in režim odmerjanja eltrombopaga prilagajati na osnovi števila trombocitov, kot je prikazano v preglednici 3.
English: Uncommon Thrombotic microangiopathy with acute renal failure
Slovenian: Bolezni sečil občasni trombotična mikroangiopatija z akutno odpovedjo ledvic
English: Five of the 6 patients treated with eltrombopag experienced the TEE at a platelet count >200,000/µl.
Slovenian: Petim od 6 bolnikov, ki so se zdravili z eltrombopagom, so se trombembolični dogodki pojavili pri številu trombocitov >200.000/µl.
English: Medicinal products for treatment of ITP
Slovenian: Zdravila za zdravljenje ITP
English: Common Blood bilirubin increased, weight decreased, white blood cell count decreased, haemoglobin decreased, neutrophil count decreased, international normalised ratio increased, activated partial thromboplastin time prolonged, blood glucose increased, blood albumin decreased Uncommon Electrocardiogram QT prolonged Grouped term with preferred terms oliguria, renal failure and renal impairment
Slovenian: Preiskave pogosti zvišana vrednost bilirubina v krvi, zmanjšanje telesne mase, zmanjšanje števila levkocitov, zmanjšana vrednost hemoglobina, zmanjšano število nevtrofilcev, zvišano mednarodno normalizirano razmerje, podaljšan aktiviran parcialni tromboplastinski čas, zvišana vrednost glukoze v krvi, znižana vrednost albuminov v krvi občasni podaljšanje intervala QT na elektrokardiogramu skupen izraz, ki obsega prednostne izraze za oligurijo, odpoved ledvic in okvaro ledvic
English: Platelet counts should be monitored when combining eltrombopag with other medicinal products for the treatment of ITP in order to avoid platelet counts outside of the recommended range (see section 4.2).
Slovenian: Pri uporabi eltrombopaga skupaj z drugimi zdravili za zdravljenje ITP je treba nadzirati število trombocitov, da bi se izognili številu trombocitov izven priporočenih vrednosti (glejte poglavje 4.2).
English: • swelling, pain or tenderness in one leg
Slovenian: • oteklina, bolečina ali občutljivost v eni nogi.
English: The dose of eltrombopag was adjusted during the 6-month treatment period based on individual platelet counts.
Slovenian: Odmerek eltrombopaga je bil med 6 mesečnim zdravljenjem prilagojen pri vsakem posameznem bolniku glede na število trombocitov.
English: The most common adverse reactions occurring in at least 10% of patients included headache, anaemia, decreased appetite, cough, nausea, diarrhoea, hyperbilirubinaemia, alopecia, pruritus, myalgia, pyrexia, fatigue, influenza-like illness, asthenia, chills and oedema.
Slovenian: Med najbolj pogostimi neželenimi učinki, ki so se pojavili pri najmanj 10 % bolnikov, so bili glavobol, anemija, zmanjšan apetit, kašelj, navzea, driska, hiperbilirubinemija, alopecija, srbenje, mialgija, zvišana telesna temperatura, utrujenost, gripi podobno obolenje, astenija, mrazenje in edemi.
English: • decreased number of red blood cells (anaemia) caused by excessive destruction of red blood cells (haemolytic anaemia)
Slovenian: • znižano število eritrocitov (anemija) zaradi povečane razgradnje eritrocitov (hemolitična anemija)
English: In addition, in the RAISE study, 42% of patients with baseline platelet count ≤15,000/μl treated with eltrombopag responded at the end of the 6 month treatment period.
Slovenian: Razen tega je bil v študiji RAISE na koncu 6 mesečnega obdobja zdravljenja z eltrombopagom odziv dosežen pri 42 % bolnikov z izhodiščnim številom trombocitov ≤15.000/μl.
English: Administration of a single 25 mg dose of eltrombopag as powder for oral suspension with a highcalcium, moderate-fat and moderate-calorie meal reduced plasma eltrombopag mean AUC0-∞ by 75% and mean Cmax by 79%.
Slovenian: Pri odmerjanju enkratnega 25-miligramskega odmerka eltrombopaga v obliki praška za peroralno suspenzijo skupaj z zajtrkom z veliko vsebnostjo kalcija, zmerno vsebnostjo maščob in zmerno vsebnostjo kalorij se je povprečna vrednost AUC0- eltrombopaga v plazmi zmanjšala za 75 %, povprečna vrednost Cmax pa za 79 %.
English: Revolade 12.5 mg film-coated tablets Revolade 25 mg film-coated tablets Revolade 50 mg film-coated tablets Revolade 75 mg film-coated tablets eltrombopag
Slovenian: Revolade 12,5 mg filmsko obložene tablete Revolade 25 mg filmsko obložene tablete Revolade 50 mg filmsko obložene tablete Revolade 75 mg filmsko obložene tablete eltrombopag
English: Take only the prescribed number of sachets for one dose out of the kit.
Slovenian: Iz kompleta vzemite samo toliko vrečic, kolikor vam jih je zdravnik predpisal za en odmerek.
English: • skin problems including small red or purple spots caused by bleeding into the skin (petechiae)
Slovenian: • težave s kožo, med drugim majhne rdeče ali vijolične pikčaste spremembe zaradi drobnih krvavitev v kožo (petehije), izpuščaj, srbenje, kožne spremembe
English: Across the 3 placebo-controlled studies in adults with chronic ITP, 1 patient in the placebo group and 1 patient in the eltrombopag group experienced a Grade 4 liver test abnormality.
Slovenian: V treh s placebom kontroliranih študijah pri odraslih s kronično ITP so se nenormalne vrednosti testov jetrne funkcije stopnje 4 pojavile pri enem bolniku v skupini s placebom in enem bolniku v skupini z eltrombopagom.
English: The tablets should be taken at least two hours before or four hours after any products such as antacids, dairy products (or other calcium containing food products), or mineral supplements containing polyvalent cations (e.g. iron, calcium, magnesium, aluminium, selenium and zinc) (see sections 4.5 and 5.2).
Slovenian: Bolnik mora tablete vzeti vsaj dve uri pred ali štiri ure po kateremkoli zdravilu, kot so antacidi, živila mlečnega izvora (ali druga živila, ki vsebujejo kalcij) ali mineralna prehranska dopolnila, ki vsebujejo polivalentne katione (npr. železo, kalcij, magnezij, aluminij, selen in cink) (glejte poglavji 4.5 in 5.2).
English: • Place the tip of the syringe into the inside of the child's cheek.
Slovenian: • Vrh brizge dajte v otrokova usta v smeri proti licu.
English: Give the medicine to the child. Do this straight away when you have mixed the dose.
Slovenian: Zdravilo dajte otroku takoj po tem, ko ste ga pripravili.
English: • Throw away the used oral dosing syringe.
Slovenian: • Uporabljeno brizgo za peroralno odmerjanje zavrzite.
English: Chronic hepatitis C associated thrombocytopenia studies
Slovenian: Študije trombocitopenije povezane s kroničnim hepatitisom C
English: Patients with impaired renal function should use eltrombopag with caution and close monitoring, for example by testing serum creatinine and/or performing urine analysis (see section 5.2).
Slovenian: Takšne bolnike je treba skrbno nadzirati, na primer s preiskavami vrednosti serumskega kreatinina in/ali z analizami urina (glejte poglavje 5.2).
English: Patients were diagnosed with chronic ITP for at least 1 year and were refractory or relapsed to at least one prior ITP therapy or unable to continue other ITP treatments for a medical reason and had platelet count <30,000/µl.
Slovenian: Vključeni so bili bolniki, ki so imeli diagnozo kronične ITP že najmanj eno leto in pri katerih ni prišlo do odziva na predhodno zdravljenje oziroma se je bolezen ponovila po predhodnem zdravljenju z najmanj enim od zdravil za ITP ali pa bolniki iz zdravstvenih razlogov niso smeli nadaljevati zdravljenja z drugim zdravilom za ITP, njihovo število trombocitov pa je bilo <30.000/µl.
English: • skin changes, including rash, dry skin, eczema, redness of the skin, itching, excessive sweating,
Slovenian: • spremembe na koži, med drugim izpuščaj, suha koža, ekcem, pordelost kože, srbenje,
English: • muscle pain, muscle weakness
Slovenian: • bolečine v mišicah, oslabelost mišic
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
Slovenian: PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA NA MANJŠIH STIČNIH OVOJNINAH
English: Immune (primary) thrombocytopenia
Slovenian: Imunska (primarna) trombocitopenija
English: Unchanged eltrombopag excreted in faeces accounts for approximately 20% of the dose.
Slovenian: Z blatom se v nespremenjeni obliki izloči približno 20 % odmerka eltrombopaga.
English: The co-administration of 200 mg ciclosporin decreased the Cmax and the AUCinf of eltrombopag by 25% and 18%, respectively.
Slovenian: Sočasno odmerjanje 200 mg ciklosporina je znižalo Cmax eltrombopaga za 25 % in zmanjšalo AUCinf eltrombopaga za 18 %.
English: The pharmacokinetics of eltrombopag have been studied after administration of eltrombopag to adult patients with renal impairment.
Slovenian: Farmakokinetiko eltrombopaga so raziskovali pri odraslih bolnikih z okvaro ledvic.
English: Table 9 Geometric mean (95% CI) steady-state plasma eltrombopag pharmacokinetic parameters in patients with chronic HCV
Slovenian: Preglednica 9 Geometrijski srednji (95 % interval zaupanja) farmakokinetični parametri eltrombopaga v stanju dinamičnega ravnovesja pri bolnikih s kroničnim HCV
English: • Slowly push the plunger all the way into the syringe.
Slovenian: • Počasi potiskajte bat v brizgo do konca.
English: It is necessary to wait for at least 2 weeks to see the effect of any dose adjustment on the patient's platelet response prior to considering another dose adjustment.
Slovenian: Pred razmislekom o naslednji prilagoditvi odmerka je treba počakati najmanj dva tedna, da se pokaže učinek kakršnekoli prilagoditve odmerka na odzivu števila trombocitov.
English: • Cut off the top of each sachet with scissors
Slovenian: • S škarjami odrežite vrh posamezne vrečice.
English: • joint pain (arthralgia)
Slovenian: • bolečine v sklepih (artralgija)
English: Increase daily dose by 25 mg to a maximum of 100 mg/day.
Slovenian: Dnevni odmerek povečajte za 25 mg do največjega odmerka 100 mg/dan.
English: Treatment with eltrombopag should be discontinued if the platelet count does not increase to a level sufficient to avoid clinically important bleeding after 4 weeks of eltrombopag therapy at 75 mg once daily.
Slovenian: Če se število trombocitov po 4 tednih zdravljenja z eltrombopagom v odmerku 75 mg enkrat na dan ne poveča do vrednosti, ki zadostujejo za preprečitev klinično pomembne krvavitve, je treba zdravljenje z eltrombopagom prekiniti.
English: Chronic HCV patients and severe aplastic anaemia patients with hepatic impairment should initiate eltrombopag at a dose of 25 mg once daily (see section 5.2).
Slovenian: Pri bolnikih s kroničnim HCV in bolnikih s hudo aplastično anemijo in okvaro jeter je začetni odmerek 25 mg enkrat na dan (glejte poglavje 5.2).
English: There are no PK data on the use of eltrombopag in patients ≥75 years.
Slovenian: Farmakokinetičnih podatkov o uporabi eltrombopaga pri bolnikih starih 75 let in več, ni na voljo.
English: • decreased number of red blood cells (anaemia)
Slovenian: • znižano število eritrocitov (anemija)
English: • if you have cataracts (the lens of the eye getting cloudy)
Slovenian: • če imate katarakto (motnost očesne leče).
English: These may affect more than 1 in 10 children:
Slovenian: Lahko se pojavijo pri več kot 1 od 10 otrok:
English: Eltrombopag does not stimulate platelet production in mice, rats or dogs because of unique TPO receptor specificity.
Slovenian: Zaradi unikatne specifičnosti TPO receptorjev eltrombopag ne stimulira produkcije trombocitov pri miših, podganah ali psih.
English: • increased levels of blood bilirubin (a substance produced by the liver)
Slovenian: • zvišana vrednost bilirubina v krvi (snovi, ki nastaja v jetrih)
English: Your doctor will discuss this with you.
Slovenian: To tveganje vam bo pojasnil zdravnik.
English: Contact a doctor or pharmacist immediately.
Slovenian: o tem takoj obvestite zdravnika.
English: Fifty-four percent of the eltrombopag-treated patients and 13% of placebo-treated patients achieved this level of response after 6 weeks of treatment.
Slovenian: Ta nivo odziva je bil po 6 tednih zdravljenja dosežen pri 54 % bolnikov, ki so se zdravili z eltrombopagom, in 13 % bolnikov, ki so prejemali placebo.
English: Also there was no effect on embryofoetal development in rabbits at doses up to 150 mg/kg/day, the highest dose tested (0.3 to 0.5 times the human clinical exposure in ITP patients at 75 mg/day and HCV patients at 100 mg/day, based on AUC).
Slovenian: Vplivov na embriofetalni razvoj niso zasledili niti pri kuncih pri odmerkih do 150 mg/kg/dan, to je pri največjem raziskovanem odmerku (0,3 do 0,5-kratna izpostavljenost človeka pri klinični uporabi pri bolnikih z ITP pri odmerkih 75 mg/dan in pri bolnikih s HCV pri odmerkih 100 mg/dan, na osnovi vrednosti AUC).
English: Overall, total bilirubin ≥1.5 x ULN was reported in 76% and 50% of the eltrombopag and placebo groups, respectively.
Slovenian: Skupno so poročali o vrednosti celokupnega bilirubina, ki je  1,5-kratnik ZMN, pri 76 % bolnikov v skupini z eltrombopagom in pri 50 % bolnikov v skupini s placebom.
English: The treatment should not be initiated when the patients has existing cytogenetic abnormalities of chromosome 7.
Slovenian: Bolnikom s prisotno citogenetsko nepravilnostjo kromosoma 7 se zdravljenja ne sme uvesti.
English: Patients should be clinically evaluated periodically and continuation of treatment should be decided on an individual basis by the treating physician.
Slovenian: Odločitev o nadaljevanju zdravljenja mora sprejeti lečeči zdravnik pri vsakem bolniku posebej.
English: Revolade 75 mg film-coated tablets are round, biconvex, pink, debossed with ‘GS FFS' and ‘75' on one side.
Slovenian: Revolade 75 mg filmsko obložene tablete so okrogle, obojestransko izbočene, roza filmsko obložene tablete z oznakama ‘GS FFS' in ‘75' na eni strani.
English: It is used to help increase the number of platelets in your blood.
Slovenian: Zdravilo deluje tako, da zviša število trombocitov v krvi.
English: TRA100773B: The primary efficacy endpoint was the proportion of responders, defined as ITP patients who had an increase in platelet counts to 50,000/l at Day 43 from a baseline of <30,000/l; patients who withdrew prematurely due to a platelet count 200,000/l were considered responders, those that discontinued for any other reason were considered non-responders irrespective of platelet count.
Slovenian: TRA100773B: Primarni opazovani dogodek učinkovitosti je bil delež bolnikov z odzivom, definiran kot bolniki z ITP, s povečanjem števila trombocitov na 50.000/l na 43. dan od izhodiščne vrednosti <30.000/l.
English: The following additional side effects have been reported to be associated with treatment with Revolade in children (aged 1 to 17 years) with ITP:
Slovenian: V povezavi z uporabo zdravila Revolade so pri otrocih (v starosti od 1 do 17 let) z ITP poročali o naslednjih neželenih učinkih:
English: These tests will be repeated at intervals while you are taking it.
Slovenian: Krvne preiskave bo nato med zdravljenjem ponavljal v rednih časovnih presledkih.
English: In 2 controlled clinical studies in thrombocytopenic patients with HCV, hepatic decompensation (ascites, hepatic encephalopathy, variceal haemorrhage, spontaneous bacterial peritonitis) occurred more frequently in the eltrombopag arm (11%) than in the placebo arm (6%).
Slovenian: V dveh kontroliranih kliničnih študijah pri trombocitopeničnih bolnikih s HCV je do jetrne dekompenzacije (ascites, jetrna encefalopatija, krvavitev varic, spontani bakterijski peritonitis) prišlo bolj pogosto v skupini, ki je prejemala eltrombopag (11 %) kot v skupini, ki je prejemala placebo (6 %).
English: Based on estimates from the population pharmacokinetic analysis, Asian patients had approximately 55% higher plasma eltrombopag AUC(0-) values as compared to patients of other races who were predominantly Caucasian (see section 4.2).
Slovenian: Na osnovi ocen iz analize populacijske farmakokinetike, so bile pri bolnikih azijskega porekla vrednosti AUC(0-) eltrombopaga v plazmi za 55 % večje kot pri bolnikih drugih ras, ki so bili predvsem bele rase (glejte poglavje 4.2).
English: Patients were diagnosed with ITP for at least 6 months and were refractory or relapsed to at least one prior ITP therapy with a platelet count <30,000/µl (n=67).
Slovenian: Vključeni so bili bolniki, ki so imeli diagnozo ITP že najmanj 6 mesecev in pri katerih ni prišlo do odziva na predhodno zdravljenje ali se je bolezen ponovila po predhodnem zdravljenju z najmanj enim od zdravil za ITP, njihovo število trombocitov pa je bilo <30.000/µl (n = 67).
English: In the 3 controlled clinical ITP studies, transient decreases in platelet counts to levels lower than baseline were observed following discontinuation of treatment in 8% and 8% of the eltrombopag and placebo groups, respectively (see section 4.4).
Slovenian: V 3 kontroliranih ITP kliničnih študijah so o prehodnem zmanjšanju števila trombocitov na vrednosti, manjše od izhodiščnih vrednosti, poročali pri 8 % bolnikov v skupinah, ki so prejemale eltrombopag, in 8 % bolnikov v skupinah, ki so prejemale placebo (glejte poglavje 4.4).
English: • increased levels of bilirubin (a substance produced by the liver)
Slovenian: • zvišana vrednost bilirubina (snovi, ki nastaja v jetrih)
English: • the loss of function of part of the lung caused by a blockage in the lung artery
Slovenian: • izguba funkcije dela pljuč zaradi zapore pljučne arterije (pljučni infarkt)
English: • including yellowing of the eyes and skin (see ‘Liver problems' earlier in section 4)
Slovenian: • težave z jetri, ki lahko vključujejo porumenevanje oči in kože (glejte začetni del poglavja 4
English: Common Depression, anxiety, sleep disorder Uncommon Confusional state, agitation
Slovenian: Psihiatrične motnje pogosti depresija, anksioznost, motnje spanja občasni stanje zmedenosti, agitacija
English: >150,000/µl to 250,000/µl
Slovenian: >150.000/µl do 250.000/µl
English: Haemorrhages occurred on the surface of the retina (preretinal), under the retina (subretinal), or within the retinal tissue.
Slovenian: Krvavitve so se pojavile na površini mrežnice, pod mrežnico ali znotraj tkiva mrežnice.
English: • decreased number of platelets (thrombocytopenia)
Slovenian: • znižano število trombocitov (trombocitopenija)
English: If this happens, wash the area immediately with soap and water.
Slovenian: Če pride do tega, predel kože, ki je prišel v stik z zdravilom, takoj umijte z milom in vodo.
English: Within two weeks of stopping Revolade, your blood platelet count will usually drop back down to what it was before starting Revolade.
Slovenian: Krvavitve ali modrice po prekinitvi zdravljenja V dveh tednih po prekinitvi zdravljenja z zdravilom Revolade se število trombocitov običajno zmanjša na vrednosti pred začetkom zdravljenja z zdravilom Revolade.
English: In controlled studies in thrombocytopenic patients with HCV receiving interferon therapy (n=1,439), progression of pre-existing baseline cataract(s) or incident cataracts was reported in 8% of the eltrombopag group and 5% of the placebo group.
Slovenian: V kontroliranih študijah pri trombocitopeničnih bolnikih s HCV, ki so prejemali zdravljenje z interferonom (n = 1439), so poročali o napredovanju obstoječe katarakte v izhodišču ali pojavu katarakte pri 8 % v skupini, ki je prejemala eltrombopag in 5 % v skupini, ki je prejemala placebo.
English: You may be at higher risk of blood clots: as you get older if you have had to stay in bed for a long time if you have cancer if you are taking the contraceptive birth control pill or hormone replacement therapy if you have recently had surgery or received a physical injury if you are very overweight (obese) if you are a smoker if you have advanced chronic liver disease If any of these apply to you tell your doctor before starting treatment.
Slovenian: Tveganje za nastanek krvnih strdkov boste imeli večje: s starostjo, pri dolgotrajnem mirovanju, če imate rakavo obolenje, v primeru uporabe hormonskih kontraceptivov ali hormonskega nadomestnega zdravljenja, po nedavnem kirurškem posegu ali telesni poškodbi (travma), v primeru prekomerne telesne mase (debelost), če kadite, če imate napredovalo kronično bolezen jeter.
English: Tablet coating Hypromellose (E464) Iron oxide red (E172) Iron oxide black (E172) Macrogol 400 (E1521) Titanium dioxide (E171)
Slovenian: Obloga tablete hipromeloza (E464) rdeči železov oksid (E172) črni železov oksid (E172) makrogol 400 (E1521) titanov dioksid (E171)
English: Pooled data
Slovenian: DRUGI PODATKI
English: • swelling, pain, heat, redness, or tenderness in one leg
Slovenian: • oteklina, bolečina, topla in rdeča koža ali občutljivost v eni nogi.
English: Eltrombopag was administered to 302 ITP patients in the open-label extension study EXTEND (TRA105325), 218 patients completed 1 year, 180 completed 2 years, 107 completed 3 years, 75 completed 4 years, 34 completed 5 years and 18 completed 6 years.
Slovenian: Enoletno zdravljenje je bilo dokončano pri 218 bolnikih, dveletno zdravljenje pri 180 bolnikih, triletno zdravljenje pri 107 bolnikih, štiriletno zdravljenje pri 75 bolnikih, petletno zdravljenje pri 34 bolnikih in šestletno zdravljenje pri 18 bolnikih.
English: The most common adverse reactions occurring in at least 10% of patients included headache, dizziness, cough, oropharyngeal pain, nausea, diarrhoea, abdominal pain, transaminases increased, arthralgia, pain in extremity, fatigue and pyrexia.
Slovenian: Med najbolj pogostimi neželeni učinki, ki so se pojavili pri najmanj 10 % bolnikov, so bili glavobol, omotica, kašelj, orofaringealna bolečina, navzea, driska, bolečine v trebuhu, zvišane vrednosti aminotransferaz, artralgija, bolečine v okončinah, utrujenost in zvišana telesna temperatura.
English: Revolade 25 mg powder for oral suspension eltrombopag
Slovenian: Revolade 25 mg prašek za peroralno suspenzijo eltrombopag
English: People with ITP have an increased risk of bleeding.
Slovenian: Pri bolnikih z idiopatično trombocitopenično purpuro obstaja večje tveganje za pojav krvavitev.
English: Therefore, caution should be used when co-administration of eltrombopag with lopinavir/ritonavir takes place.
Slovenian: Pri sočasni uporabi eltrombopaga in lopinavirja/ritonavirja je zato potrebna previdnost.
English: • inflammation of the nasal passages, throat and mouth, flu-like symptoms, dry mouth, sore or inflamed mouth, toothache
Slovenian: • vnetje nosnih hodnikov, žrela oziroma grla in ust, gripi podobni simptomi, suha usta, vnetje ustne sluznice, zobobol
English: Thrombocytopenia following discontinuation of treatment
Slovenian: Trombocitopenija po prekinitvi zdravljenja
English: At baseline, more than 70% of ITP patients in each treatment group reported any bleeding (WHO Grades 1-4) and more than 20% reported clinically significant bleeding (WHO Grades 2-4), respectively.
Slovenian: V izhodišču so o pojavu katerekoli krvavitve (stopnje 1-4 po SZO) poročali pri več kot 70 % bolnikov z ITP v vseh skupinah zdravljenja, o pojavu klinično pomembne krvavitve (stopnje 2-4 po SZO) pa pri več kot 20 % bolnikov v vseh skupinah zdravljenja.
English: Human liver microsome studies identified UGT1A1 and UGT1A3 as the enzymes responsible for eltrombopag glucuronidation.
Slovenian: Študije s humanimi jetrnimi mikrosomi so pokazale, da sta za glukuronidacijo eltrombopaga odgovorna encima UGT1A1 in UGT1A3.
English: • antacids, a type of medicine for indigestion and heartburn
Slovenian: • antacidov, ki so zdravila za zdravljenje prebavnih težav in zgage.