FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Medicines Agency has waived the obligation to submit the results of studies with Rasitrio in all subsets of the paediatric population in essential hypertension (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od obveze za predložitev rezultatov študij z zdravilom Rasitrio za vse podskupine pediatrične populacije pri esencialni hipertenziji (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: You should tell your doctor if you are 65 years of age or older because you may be more susceptible to side effects related to low blood pressure (see section 4 on possible side effects).
Slovenian: Svojega zdravnika morate opozoriti, če ste stari 65 let ali več, saj ste lahko zato bolj nagnjeni k neželenim učinkom, ki so povezani z nizkim krvnim tlakom (glejte poglavje 4 o možnih neželenih učinkih).
English: Not all pack sizes may be available in your country.
Slovenian: V vaši državi na trgu morda ni vseh navedenih velikosti pakiranj.
English: • Obligation to conduct post-authorisation measures The MAH shall complete, within the stated timeframe, the below measures:
Slovenian: • Obveznost izvedbe ukrepov po pridobitvi dovoljenja za promet Imetnik dovoljenja za promet z zdravilom mora v določenem časovnem okvirju izvesti naslednje ukrepe:
English: The findings from 2- and 13-week oral toxicity studies were consistent with those for the individual components.
Slovenian: Rezultati 2-tedenske in 13-tedenske študije toksičnosti pri peroralnem odmerjanju so skladni z rezultati študij posameznih učinkovin.
English: • bruising and frequent infections (aplastic anaemia)
Slovenian: • podplutbe in pogoste okužbe (aplastična anemija)
English: Amlodipine can have minor or moderate influence on the ability to drive and use machines.
Slovenian: Amlodipin ima lahko blag do zmeren vpliv na sposobnost vožnje in upravljanja s stroji.
English: Children and adolescents The use of Rasitrio in children and adolescents up to 18 years of age is not recommended.
Slovenian: Otroci in mladostniki Uporaba zdravila Rasitrio pri otrocih in mladostnikih do 18. leta starosti ni priporočena.
English: - CYP450 interactions
Slovenian: - Medsebojno delovanje s CYP450
English: Aliskiren plasma protein binding is moderate (47-51%) and independent of the concentration.
Slovenian: Aliskiren se zmerno veže na proteine v plazmi (47-51 %) in sicer neodvisno od koncentracije.
English: Serious adverse reactions include anaphylactic reaction and angioedema which have been reported in post-marketing experience and may occur rarely (less than 1 case per 1,000 patients).
Slovenian: Resni neželeni učinki vključujejo anafilaktično reakcijo in angioedem, o katerih so poročalimed izkušnjami v obdobju trženja zdravila, pojavljata pa se redko (manj kot 1 primer na 1.000 bolnikov).
English: Not recommended (see section 4.2) - Grapefruit juice
Slovenian: Zdravila, ki se jih ne priporoča (glejte poglavje 4.2) - Grenivkin sok
English: Aliskiren was not teratogenic in rats or rabbits (see section 5.3).
Slovenian: Aliskiren ni bil teratogen pri podganah ali kuncih (glejte poglavje 5.3).
English: • increased muscle stiffness and inability to stretch
Slovenian: • povečana okorelost mišic in nezmožnost mišic, da se raztegnejo
English: You may need to stop Rasitrio.
Slovenian: Morda boste morali prenehati z jemanjem zdravila Rasitrio.
English: The adverse reactions for aliskiren, amlodipine and hydrochlorothiazide are ranked under heading of frequency, the most frequent first, using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).
Slovenian: Neželeni učinki aliskirena, amlodipina in hidroklorotiazida so razvrščeni po skupinah glede na pogostnost, najpogostejši najprej, pri čemer je uporabljen naslednji dogovor: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: Do not take this medicine if you are pregnant (see section Do not take Rasitrio).
Slovenian: Če ste noseči, ne jemljite tega zdravila (glejte poglavje Ne jemljite zdravila Rasitrio).
English: As expected for a compound which is cleared almost exclusively via the kidneys, renal function has a marked effect on the kinetics of hydrochlorothiazide.
Slovenian: Kot je mogoče pričakovati pri spojini, ki se izloča skoraj izključno preko ledvic, ima delovanje ledvic izrazit vpliv na kinetiko hidroklorotiazida.
English: If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA.
Slovenian: Če je ponovna uvedba diuretika neizogibna, je priporočena zaščita izpostavljenih predelov kože pred soncem ali umetno svetlobo UVA.
English: Oral co-administration of aliskiren and furosemide had no effect on the pharmacokinetics of aliskiren but reduced exposure to furosemide by 20-30% (the effect of aliskiren on furosemide administered intramuscularly or intravenously has not been investigated).
Slovenian: Sočasna peroralna uporaba aliskirena in furosemida ni vplivala na farmakokinetiko aliskirena, je pa zmanjšala izpostavljenost furosemidu za 20-30 % (vpliva aliskirena na intramuskularno ali intravensko aplicirani furosemid niso raziskali).
English: Hydrochlorothiazide is eliminated predominantly as unchanged compound.
Slovenian: Hidroklorotiazid se pretežno izloča v nespremenjeni obliki.
English: If you forget to take Rasitrio
Slovenian: Če ste pozabili vzeti zdravilo Rasitrio
English: Carcinogenic potential was assessed in a 2-year rat study and a 6-month transgenic mouse study.
Slovenian: Karcinogeni potencial so ocenjevali v 2-letni študiji na podganah in v 6-mesečni študiji na transgenskih miših, pri čemer karcinogenega potenciala niso zasledili.
English: Swallow the tablet whole with some water.
Slovenian: Tableto pogoltnite celo z malo vode.
English: What you need to know before you take Rasitrio
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Rasitrio
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system, renin-inhibitors; ATC code C09XA54
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na renin-angiotenzinski sistem, zaviralci renina, oznaka ATC: C09XA54
English: The available data did not suggest that age, body weight or gender have any significant effect on aliskiren systemic exposure (see section 4.2).
Slovenian: Po razpoložljivih podatkih starost, telesna masa in spol nimajo pomembnega vpliva na obseg sistemske izpostavljenosti aliskirenu (glejte poglavje 4.2).
English: - Vitamin D and calcium salts
Slovenian: - Vitamin D in kalcijeve soli
English: Extensive clinical data are available for hydrochlorothiazide and these are reflected in the relevant sections.
Slovenian: O hidroklorotiazidu so na voljo obsežni klinični podatki, ki so navedeni v ustreznih poglavjih.
English: If you become pregnant while taking this medicine stop taking it immediately and talk to your doctor.
Slovenian: Če zanosite v času jemanja tega zdravila, ga takoj prenehajte jemati in se pogovorite s svojim zdravnikom.
English: Aliskiren was secreted in the milk of lactating rats.
Slovenian: Aliskiren se je izločal v mleko doječih podgan.
English: Your doctor will carefully consider whether Rasitrio is suitable for you.
Slovenian: Vaš zdravnik bo skrbno pretehtal, ali je zdravilo Rasitrio primerno za vas ali ne.
English: • severe skin reactions (toxic epidermal necrolysis and/or oral mucosal reactions - red skin,
Slovenian: • hude kožne reakcije (toksična epidermalna nekroliza in/ali reakcije ustne sluznice - rdeča koža,
English: If any of the following occur, tell your doctor straight away:
Slovenian: Če pride do katerega od spodaj navedenih učinkov, takoj obvestite zdravnika:
English: Therefore, because of the risk of therapeutic failure, grapefruit juice should not be taken together with Rasitrio.
Slovenian: Ker bi torej lahko prišlo do zmanjšanja terapevtskega učinka, se grenivkinega soka ne sme uživati skupaj z zdravilom Rasitrio.
English: These reduce the amount of angiotensin II the body can make.
Slovenian: To so zdravila, ki zmanjšujejo količino angiotenzina II, ki nastaja v telesu.
English: In vitro studies with amlodipine have shown that approximately 97.5% of circulating amlodipine is bound to plasma proteins.
Slovenian: Študije amlodipina in vitro so pokazale, da je na beljakovine v plazmi vezanega približno 97,5 % zdravila v obtoku.
English: Hypersensitivity reactions to hydrochlorothiazide may occur in patients, but are more likely in patients with allergy and asthma.
Slovenian: Pri bolnikih lahko pride do preobčutljivostnih reakcij na hidroklorotiazid, vendar je verjetnost večja pri bolnikih z alergijo in astmo.
English: Not recommended - Lithium
Slovenian: Sočasna uporaba ni priporočena - Litij
English: Patients 65 years of age or older are more susceptible to side effects related to low blood pressure.
Slovenian: Bolniki, ki so stari 65 let ali več, so bolj nagnjeni k neželenim učinkom, ki so povezani z nizkim krvnim tlakom.
English: Chloride deficit is generally mild and usually does not require treatment.
Slovenian: Pomanjkanje kloridov je običajno blago in ga ni treba zdraviti.
English: Women of childbearing potential/contraception in males and females Healthcare professionals prescribing Rasitrio should counsel women of childbearing potential about the potential risk during pregnancy.
Slovenian: Ženske v rodni dobi/kontracepcija pri moških in ženskah Zdravniki, ki predpisujejo zdravilo Rasitrio, morajo ženskam v rodni dobi razložiti možna tveganja uporabe zdravila med nosečnostjo.
English: • abnormal liver function test
Slovenian: • nenormalni izvidi testov jetrne funkcije
English: The time to reach peak plasma concentrations of amlodipine is similar in elderly and younger subjects.
Slovenian: Čas do najvišje koncentracije amlodipina v plazmi je pri starejših in mlajših bolnikih podoben.
English: In experimental animals, it has been shown that P-gp is a major determinant of aliskiren bioavailability.
Slovenian: Na poskusnih živalih se je pokazalo, da je P-gp glavna determinanta biološke uporabnosti aliskirena.
English: Patients should be rehydrated before administration.
Slovenian: Bolnike je treba pred uporabo kontrastnih sredstev rehidrirati.
English: Mutagenicity studies revealed no effects related to the medicinal product at either the gene or chromosome levels.
Slovenian: Študije mutagenosti niso pokazale nobenih z zdravilom povezanih učinkov niti na ravni genov niti na ravni kromosomov.
English: Dose should be individualised and adjusted according to the patient's clinical response.
Slovenian: Odmerek je treba prilagoditi posameznemu bolniku in njegovemu kliničnemu odzivu.
English: The safety of amlodipine in human pregnancy has not been established.
Slovenian: Varnosti uporabe amlodipina med nosečnostjo pri človeku niso dokazali.
English: Rats and mice treated with amlodipine in the diet for two years, at concentrations calculated to provide daily dosage levels of 0.5, 1.25 and 2.5 mg/kg/day showed no evidence of carcinogenicity.
Slovenian: Pri podganah in miših, ki so jim 2 leti s hrano dajali amlodipin v koncentracijah, preračunanih tako, da so zagotavljale dnevne ravni odmerkov 0,5, 1,25 in 2,5 mg/kg/dan, niso ugotovili nobenega dokaza za kancerogenost.
English: • decrease in vision or pain in your eyes due to high pressure (possible signs of acute-angle closure glaucoma)
Slovenian: • poslabšanje vida ali bolečina v očeh zaradi visokega očesnega tlaka (možni znaki akutnega glavkoma zaprtega zakotja)
English: Anaphylactic reactions and angioedema
Slovenian: Anafilaktične reakcije in angioedem
English: 85 to 90% of the maximal bloodpressure-lowering effect was observed after 2 weeks.
Slovenian: Po dveh tednih so opažali 85 do 90 % izraženost največjega učinka zniževanja krvnega tlaka.
English: Rasitrio should be taken with a light meal once a day, preferably at the same time each day.
Slovenian: Zdravilo Rasitrio je treba jemati z lahkim obrokom enkrat na dan, najbolje vsak dan ob istem času.
English: Amlodipine belongs to a group of medicines known as calcium channel blockers, which help to control high blood pressure.
Slovenian: Amlodipin sodi v skupino zdravil, ki jih imenujemo zaviralci kalcijevih kanalčkov in pomagajo uravnavati visok krvni tlak.
English: Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of treatment initiation.
Slovenian: Simptomi vključujejo akutno poslabšanje ostrine vida ali bolečine v očeh in se praviloma pojavijo v obdobju nekaj ur do nekaj tednov po začetku zdravljenja.
English: Caution required with concomitant use - P-gp interactions
Slovenian: Zdravila, pri katerih je potrebna previdnost pri sočasni uporabi - Interakcije povezane s P-gp
English: • Combined use of aliskiren with other agents acting on the RAAS.
Slovenian: • pri kombinirani uporabi aliskirena in drugih zdravil, ki delujejo na RAAS.
English: • decreased skin sensitivity
Slovenian: • zmanjšana občutljivost kože
English: • Patients with marked volume depletion or patients with salt depletion (e.g. those receiving high doses of diuretics) or
Slovenian: • pri bolnikih z izrazito hipovolemijo ali pri bolnikih s primanjkljajem natrija (na primer pri tistih, ki prejemajo visoke odmerke diuretikov) ali
English: (Calculations assume an oral dose of 25 mg/day and a 60-kg patient.)
Slovenian: (za izračun so predpostavljali, da 60-kilogramski bolniku zaužije odmerek 25 mg/dan).
English: In addition, an increased incidence of adverse events was observed with aliskiren compared to placebo (37.9% versus 30.2%).
Slovenian: Poleg tega so pri uporabi aliskirena v primerjavi s placebom opažali povečano pogostnost neželenih dogodkov (37,9 % v primerjavi s 30,2 %).
English: In patients taking amlodipine alone, the following have been reported: Common (may affect up to 1 in 10 people)
Slovenian: Pri bolnikih, ki so jemali samo amlodipin, so poročali o naslednjih neželenih učinkih: pogosti (lahko se pojavijo pri največ 1 od 10 ljudi)
English: • stomach discomfort after meal
Slovenian: • bolečine v želodcu po obroku
English: If anaphylactic reactions or angioedema occur, Rasitrio should be promptly discontinued and appropriate therapy and monitoring provided until complete and sustained resolution of signs and symptoms has occurred.
Slovenian: Če pride do anafilaktične reakcije ali angioedema, je treba zdravljenje z zdravilom Rasitrio takoj prekiniti in poskrbeti za ustrezno zdravljenje in spremljanje bolnika, dokler znaki in simptomi niso v celoti in trajno odpravljeni.
English: With cessation of treatment, blood pressure gradually returned towards baseline levels over a period of several weeks, with no evidence of a rebound effect for blood pressure or PRA.
Slovenian: Po prenehanju zdravljenja se je krvni tlak v obdobju nekaj tednov postopoma vrnil na izhodiščno vrednost, pri tem ni bilo nobenih znakov za povratni učinek niti glede krvnega tlaka niti glede PRA.
English: Other medicines and Rasitrio
Slovenian: Druga zdravila in zdravilo Rasitrio
English: • red skin (erythema).
Slovenian: • rdečina (eritem)
English: • allergic reactions (hypersensitivity)
Slovenian: • alergijske reakcije (preobčutljivost)
English: There is no data available regarding the effect of CYP3A4 inducers on amlodipine.
Slovenian: O vplivu induktorjev CYP3A4 na amlodipin ni na voljo nobenih podatkov.
English: Similar reductions were found when aliskiren was combined with other antihypertensive medicinal products.
Slovenian: Do podobnega znižanja pride tudi pri uporabi aliskirena v kombinaciji z drugimi antihipertenzivnimi zdravili.
English: • kidney problems including acute renal failure (severely decreased urine output)
Slovenian: • težave z ledvicami, vključno z akutno ledvično odpovedjo (zelo zmanjšanim nastajanjem urina)
English: Amlodipine is extensively (approximately 90%) metabolised in the liver to inactive metabolites, with 10% of the parent compound and 60% of the metabolites excreted in the urine.
Slovenian: Amlodipin se v jetrih v veliki meri (približno v 90 %) presnovi v neaktivne presnovke, pri čemer se 10 % matične spojine in 60 % presnovkov izloči v urin.
English: The use of Rasitrio during breast-feeding is not recommended.
Slovenian: Uporaba zdravila Rasitrio med dojenjem ni priporočena.
English: Meals (low or high fat content) have been shown to reduce the absorption of aliskiren substantially (see section 4.2).
Slovenian: Pokazalo se je, da obroki (z veliko ali z majhno vsebnostjo maščob) bistveno zmanjšajo absorpcijo aliskirena (glejte poglavje 4.2).
English: Paediatric population: Based on the limited amount of safety data available from a pharmacokinetic study of aliskiren treatment in 39 hypertensive children 6-17 years of age, the frequency, type and severity of adverse reactions in children are expected to be similar to that seen in hypertensive adults.
Slovenian: Pediatrična populacija: Na podlagi omejenega obsega podatkov o varnosti iz farmakokinetične študije zdravljenja z aliskirenom pri 39 otrocih, ki so imeli hipertenzijo in so bili stari od 6 do 17 let, je mogoče pri otrocih pričakovati enake pogostnosti, vrste in izraženosti neželenih učinkov, kot so jih opažali pri odraslih s hipertenzijo.
English: - Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone.
Slovenian: - Pri večkratnem sočasnem odmerjanju amlodipina 10 mg in simvastatina 80 mg je prišlo do 77 % večje izpostavljenosti simvastatinu kot pri odmerjanju samo simvastatina.
English: • severely decreased urine output (possible signs of renal disorder or renal failure), weakness
Slovenian: • zelo zmanjšano izločanje urina (možni znaki ledvične bolezni ali odpovedi ledvic), šibkost
English: Hypokalaemia may result in muscle spasms and/or accentuate cardiac arrhythmias associated with the concomitant use of digitalis glycosides or certain antiarrhythmic medicinal products.
Slovenian: Hipokaliemija lahko povzroči mišične krče in/ali stopnjuje srčne aritmije, ki so povezane s sočasno uporabo glikozidov digitalisa ali določenih antiaritmičnih zdravil.
English: Rasitrio is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if it is used after the third month of pregnancy.
Slovenian: Jemanje zdravila Rasitrio med zgodnjo nosečnostjo ni priporočljivo, ko pa ste noseči več kot 3 mesece, ga ne smete jemati, ker lahko uporaba po tretjem mesecu nosečnosti povzroči resno škodo vašemu otroku.
English: Always take this medicine exactly as your doctor has told you and do not exceed the recommended dose.
Slovenian: Pri jemanju tega zdravila natančno upoštevajte navodila svojega zdravnika in ne prekoračite predpisanega odmerka.
English: Co-administration of lithium and hydrochlorothiazide is not recommended.
Slovenian: Sočasna uporaba litija in hidroklorotiazida ni priporočena.
English: Aliskiren is minimally excreted via the renal route, and only 0.6% of the aliskiren dose is recovered in urine following oral administration (see section 5.2).
Slovenian: Aliskiren se le v majhni meri izloča skozi ledvice in po peroralnem odmerjanju je mogoče v urinu prestreči samo 0,6 % odmerka aliskirena (glejte poglavje 5.2).
English: The usual dose of Rasitrio is one tablet a day.
Slovenian: Običajni odmerek zdravila Rasitrio je ena tableta na dan.
English: Aliskiren/hydrochlorothiazide and aliskiren/amlodipine Non-clinical studies of the toxicology of Rasitrio alone have not been conducted as these studies have been conducted for the individual components.
Slovenian: Aliskiren/hidroklorotiazid in aliskiren/amlodipin Nekliničnih študij toksičnega vpliva samega zdravila Rasitrio niso izvajali, saj so tovrstne študije izvedli za posamezne učinkovine.
English: Very common Increases in cholesterol and triglycerides Rare
Slovenian: Preiskave zelo pogosti zvišane vrednosti holesterola in trigliceridov redki glikozurija
English: Amlodipine elimination from plasma is biphasic with a terminal elimination half-life of approximately 30 to 50 hours.
Slovenian: Eliminacija amlodipina iz plazme je dvofazna s terminalnim razpolovnim časom eliminacije približno 30 do 50 ur.
English: However, since aliskiren has been shown to be a substrate for the organic anion-transporting polypeptide 1A2 (OATP1A2) (see interaction with organic anion transporting polypeptide (OATP) inhibitors), there is a potential for aliskiren to reduce plasma torasemide exposure by an interference with the absorption process.
Slovenian: Ker pa so dokazali, da je aliskiren substrat polipeptidnega prenašalca organskih anionov 1A2 (OATP1A2) (glejte možnost medsebojnega delovanja z zaviralci polipeptidnega prenašalca organskih anionov), obstaja možnost, da aliskiren z oviranjem procesa absorpcije znižuje izpostavljenost torasemidu v plazmi.
English: Investigations: In controlled clinical trials, clinically relevant changes in standard laboratory parameters were uncommonly associated with the administration of aliskiren.
Slovenian: Preiskave: V kontroliranih kliničnih preskušanjih je bila uporaba aliskirena občasno povezana s klinično pomembnimi spremembami standardnih laboratorijskih parametrov.
English: The available clinical data did not indicate that higher doses of torasemide were used after coadministration with aliskiren.
Slovenian: Razpoložljivi klinični podatki ne kažejo, da so po sočasnem odmerjanju z aliskirenom uporabljali višje odmerke torasemida.
English: - Pressor amines (e.g. noradrenaline, adrenaline) Hydrochlorothiazide may reduce the response to pressor amines such as noradrenaline.
Slovenian: - Presorski amini (npr. noradrenalin, adrenalin) Hidroklorotiazid lahko zmanjša odziv na presorske amine, kot je noradrenalin.
English: A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use.
Slovenian: Za vzpostavljanje žilnega tonusa in krvnega tlaka je lahko koristna uporaba vazokonstriktorja, razen če ta ni kontraindicirana.
English: Aliskiren Aliskiren is an orally active, non-peptide, potent and selective direct inhibitor of human renin.
Slovenian: Aliskiren je peroralno delujoč nepeptiden močan in selektiven neposreden zaviralec človeškega renina.
English: Whereas other medicinal products that inhibit the RAAS (ACEI and angiotensin II receptor blockers (ARB)) cause a compensatory rise in plasma renin activity (PRA), treatment with aliskiren decreases PRA in hypertensive patients by approximately 50 to 80%.
Slovenian: V nasprotju z drugimi zdravili, ki zavirajo RAAS (zaviralci ACE in antagonisti angiotenzina II) in povzročajo kompenzacijsko zvišanje aktivnosti renina v plazmi, pa zdravljenje z aliskirenom zniža PRA pri hipertenzivnih bolnikih za približno 50 do 80 %.
English: Hydrochlorothiazide should not be used for gestational oedema, gestational hypertension or pre-eclampsia due to the risk of decreased plasma volume and placental hypoperfusion, without a beneficial effect on the course of the disease.
Slovenian: Hidroklorotiazida se ne sme uporabljati pri gestacijskem edemu, gestacijski hipertenziji ali preeklampsiji zaradi tveganja za zmanjšanje volumna plazme in placentalne hipoperfuzije, pri čemer ni pozitivnih učinkov na potek bolezni.
English: Non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors), acetylsalicylic acid and non-selective NSAIDs: As with other agents acting on the renin-angiotensin system, NSAIDs may reduce the anti-hypertensive effect of aliskiren.
Slovenian: Nesteroidna protivnetna zdravila (NSAIDs), vključno s selektivnimi zaviralci ciklooksigenaze-2 (z zaviralci COX-2), acetilsalicilno kislino in neselektivnimi NSAIDs: Tako kot druga zdravila, ki vplivajo na sistem renin-angiotenzin, lahko nesteroidna protivnetna zdravila zmanjšajo antihipertenzivno delovanje aliskirena.