FrancophonIA/ELRC3.0 huggingface dataset:
English: In cases of suspected overdose, symptomatic and supportive therapy should be given as appropriate, including ECG monitoring because of the possibility of QTc interval prolongation (see section 4.4)
Danish: I tilfælde af en mistænkt overdosering bør symptomatisk og støttende behandling gives som hensigtsmæssigt, herunder EKG-overvågning på grund af muligheden for forlængelse af QTc-intervallet (se pkt.
English: • Antiarrhythmics (e.g. amiodarone, disopyramide, dofetilide, ibutilide, procainamide, quinidine, hydroquinidine, sotalol).
Danish: • Antiarytmika (f.eks. amiodaron, disopyramid, dofetilid, ibutilid, procainamid, quinidin, hydroquinidin, sotalol).
English: Caution is recommended when co-administering Eurartesim with medicinal products exhibiting variable patterns of inhibition, induction or competition for CYP3A4 as the therapeutic and/or toxic effects of some co-administered medicinal products could be altered.
Danish: Der rådes til forsigtighed, når Eurartesim indgives samtidigt med lægemidlersom hæmmer, inducerer eller konkurrerer om CYP3A4, da der hermed er potentiel risiko for ændring af de terapeutiske og/eller toksiske virkninger af visse lægemidler ved samtidig indgift.
English: 13 to <24
Danish: 13 til <24
English: Frequency of ADRs in paediatric patients participating in clinical studies with Eurartesim:
Danish: Frekvens af bivirkninger blandtvoksne patienter, der deltog i kliniske undersøgelser af Eurartesim:
English: Eurartesim has not been evaluated in subjects with moderate or severe renal or hepatic insufficiency.
Danish: Eurartesim er ikke blevet evalueret hos forsøgspersoner med moderat eller alvorlig nyre og lever insufficiens.
English: Film-coated tablet (tablet).
Danish: Filmovertrukket tablet (tablet)
English: Effect of co-administered medicinal products on Eurartesim Piperaquine is metabolised by CYP3A4 in vitro.
Danish: Virkning på lægemidler, der indgives samtidigt med Eurartesim Piperaquin metaboliseres af CYP3A4 in vitro.
English: uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Danish: De mest alvorlige bivirkninger er anført først: Meget almindelige (≥ 1/10), almindelige (≥ 1/100 til 1/10), ikke almindelige (≥ 1/1.000 til < 1/100) , sjældne (≥1/10.000 til <1/1.000), meget sjældne (<1/10.000), ikke kendt (kan ikke estimeres ud fra forhåndenværende data).
English: - Known congenital prolongation of the QTc-interval or any clinical condition known to prolong the QTc interval.
Danish: - Verificeret medfødt forlængelse af QTc-intervallet eller en klinisk tilstand, som vides at forlænge QTc-intervallet..
English: Eurartesim contains the active substances piperaquine tetraphosphate and artenimol.
Danish: Eurartesim indeholder de aktive stoffer piperaquintetrafosfat og artenimol.
English: The concurrent administration of a single dose of oral clarithromycin, (a strong CYP3A4 inhibitor probe) with a single dose of oral Eurartesim led to a modest increase (≤2-fold) in piperaquine exposure in healthy adult subjects.
Danish: Samtidig administration af en enkelt oral dosis clarithromycin (et teststof for potent CYP3A4-hæmning) og en enkelt oral dosis Eurartesim førte til en moderat forhøjelse (≤ 2 gange) af eksponeringen for piperaquin hos raske, voksne personer.
English: The above mentioned interactions for adults and the warnings in section 4.4 should be taken into account for the paediatric population.
Danish: 4.4 bør tages i betragtning hos den pædiatriske population.
English: An ECG should be obtained as early as possible during treatment with Eurartesim and ECG monitoring should be applied in patients who may have a higher risk of developing arrhythmia in association with QTc prolongation (see below).
Danish: Et EKG skal optages så tidligt som muligt under behandling med Eurartesim og EKG-overvågning skal udføres hos patienterved risiko for udvikling af arytmi i forbindelse med QTc-forlængelse (se herunder).
English: Film coating: hypromellose, titanium dioxide (E171), macrogol 400.
Danish: Filmovertræk: Hypromellose, titandioxid (E171), macrogol 400.
English: Eurartesim is contraindicated in patients already taking other medicinal products that are known to prolong the QTc interval due to the risk of a pharmacodynamic interaction leading to an additive effect on the QTc interval (see section 4.3 and 4.4).
Danish: Euratesim er kontraindiceret hos patienter, der allerede tager andre lægemidler, der vides at forlænge QTc-intervallet, på grund af risikoen for en farmakodynamisk interaktion, der fører til en additiv virkning på QTc-intervallet (se pkt.
English: Piperaquine was not teratogenic in the rat or rabbit.
Danish: Piperaquin var ikke teratogent hos rotter eller kaniner.
English: When co-administered to healthy women, Eurartesim exerted only a minimum effect on an estrogen/progestinic combination oral contraceptive treatment increasing the ethynilestradiol rate of absorption (expressed by geometric mean Cmax) of about 28% but not significantly changing the exposure to ethynilestradiol and levonorgestrel and not influencing contraception activity as demonstrated by the similar plasma concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH) and progesterone observed after oral contraceptive treatment with or without concomitant Eurartesim administration.
Danish: Absorptionshastigheden af ethinylestradiol (udtrykt ved geometrisk gennemsnitlig Cmax) blev øget med ca. 28 %, men eksponeringen for ethinylestradiol og levonorgestrel blev ikke ændret signifikant, og kontraceptionsaktiviteten blev ikke påvirket, vist ved sammenlignelige plasmakoncentrationer af follikelstimulerende hormon (FSH), luteiniserende hormon (LH) og progesteron efter behandling med orale kontraceptiva med eller uden samtidig administration af Eurartesim.
English: If Eurartesim is more suitable for a pregnant woman than other artemisinin-based combination therapies with a higher range of experience (or sulfadoxine-pyrimethamine), Eurartesim may be used in the 2nd and 3rd trimester.
Danish: Hvis Eurartesim er mere egnet til en gravid kvinde end andre artemisininbaserede kombinationsbehandlinger med et højere erfaringsgrundlag (eller sulfadoxin-pyrimethamin), kan Eurartesim anvendes i det 2. og 3. trimester.
English: If you or your child stops taking Eurartesim
Danish: Hvis du eller dit barn holder op med at tage Eurartesim
English: Contents of the pack and other information What Eurartesim contains
Danish: Pakningsstørrelser og yderligere oplysninger Eurartesim indeholder:
English: White oblong biconvex film-coated tablet (dimension 16x8mm / thickness 5.5mm) with a break-line and marked on one side with two “σ” letters.
Danish: Hvid, aflang, bikonveks filmovertrukket tablet (dimensioner 16 x 8 mm / tykkelse 5,5 mm) med en delekærv og præget på den ene side med to bogstaver “σ”.
English: • Neuroleptics (e.g. phenothiazines, sertindole, sultopride, chlorpromazine, haloperidol, mesoridazine, pimozide, or thioridazine), antidepressive medicinal products.
Danish: • Antipsykotika (f.eks. phenothiaziner, sertindol, sultoprid, chlorpromazin, haloperidol, mesoridazin, pimozid eller thioridazin), antidepressiva.
English: - Family history of sudden death or of congenital prolongation of the QTc interval.
Danish: - Familiær anamnese med pludselige dødsfald i familien eller medfødt forlængelse af QTc-intervallet.
English: Therefore, caution should be applied when co administering Eurartesim with any CYP3A4-inhibitor and ECG monitoring should be considered.
Danish: Der bør derfor udvises forsigtighed, når Eurartesim administreres sammen med CYP3A4-hæmmere, og EKG-overvågning bør overvejes.
English: These showed that QTc prolongation occurred more frequently and to a larger extent in association with Eurartesim therapy than with the comparators (see section 5.1 for details of the comparators).
Danish: Disse viste, at QTc-forlængelse forekom hyppigere og i større udstrækning i forbindelse med behandling med Euratesim i sammenligning medkomparative midler (se pkt.
English: Eurartesim should not be used to treat severe falciparum malaria (see section 4.3) and, due to insufficient data, should not be used to treat malaria due to Plasmodium vivax, Plasmodium malariae or Plasmodium ovale.
Danish: 4.3) og på grund af utilstrækkelige data, bør det ikke anvendes til behandling af malaria, som skyldes Plasmodium vivax, Plasmodium malariae eller Plasmodium ovale.
English: Eurartesim has not been evaluated in patients with moderate or severe renal or hepatic insufficiency (see section 4.2).
Danish: Eurartesim er ikke blevet evalueret hos patienter med moderat eller svært nedsat nyre- eller leverfunktion (se pkt.
English: Due to the lack of multiple dose PK data for piperaquine, administration of any strong CYP3A4-inhibitors should be discouraged after initiation (i.e. the first dose) of Eurartesim (see sections 4.5 and 5.2).
Danish: Da der ikke foreligger farmakokinetiske data for piperaquin efter gentagne doser, bør administration af en potent CYP3A4-hæmmer undgås, efter Eurartesimbehandling er påbegyndt (dvs. efter den første dosis) (se pkt.
English: Acanthosis Pruritis
Danish: Akantose Pruritus
English: Effect of Eurartesim on co-administered medicinal products Piperaquine is metabolised by, and is an inhibitor of CYP3A4.
Danish: Virkning af Eurartesim på lægemidler, der indgives samtidigt Piperaquin metaboliseres af og er en hæmmer af CYP3A4.
English: The active substances are piperaquine tetraphosphate and artenimol.
Danish: Aktive stoffer: piperaquintetraphosphat og artenimol.
English: No more than two courses of Eurartesim may be given within a 12 month period (see sections 4.4 and
Danish: Der må ikke gives over to behandlingsforløb i løbet af en 12-måneders periode (se pkt.
English: Artenimol is very rapidly absorbed, Tmax being approximately 1-2 hrs after single and multiple dosing.
Danish: Tmax indtræffer ca. 1-2 timer efter enkelt- og flerdosering.
English: Tablet core: pre-gelatinised starch, dextrin, hypromellose (E464), croscarmellose sodium, magnesium stearate (E572).
Danish: Tabletkerne: prægelatiniseret stivelse, dextrin, hypromellose (E464), croscarmellose natrium, magnesiumstearat (E572).
English: In the tables below, ADRs are listed under system organ class (SOC), and ranked by headings of frequency.
Danish: I tabellerne herunder, er bivirkninger opstillet efter systemorganklasse og rækkefølgen bestemt udfra hyppighed.
English: Therefore Eurartesim should not be used during the 1st trimester of pregnancy in situations where other suitable and effective anti-malarials are available (see section 4.4).
Danish: Eurartesim bør derfor ikke anvendes i graviditetens 1. trimester, hvor andre hensigtsmæssige og effektive lægemidler mod malaria er tilgængelige (se pkt.
English: Eurartesim should not be used during the 1st trimester of pregnancy in situations where other suitable and effective antimalarials are available (see section 4.6).
Danish: Eurartesim bør ikke anvendes i graviditetens 1. trimester, hvor andre hensigtsmæssige og effektive lægemidler mod malaria er tilgængelige (se pkt.
English: If you are not sure about any of the above, please ask your doctor or pharmacist.
Danish: Hvis du er i tvivl om noget af det ovenstående, skal du spørge din læge eller apotekspersonalet.
English: If a patient vomits within 30 minutes of taking Eurartesim, the whole dose should be re-administered; if a patient vomits within 30-60 minutes, half the dose should be re-administered.
Danish: Hvis en patient kaster op inden for 30-60 minutter, skal halvdelen af dosis indgives igen.
English: If you or your child takes more Eurartesim tablets than you should
Danish: Hvis du eller dit barn har taget for mange Eurartesim tabletter
English: Frequency of ADRs in adult patients participating in clinical studies with Eurartesim:
Danish: Hyppighed af bivirkninger blandt børn, der deltog i kliniske undersøgelser af Eurartesim:
English: There are no phototoxicity concerns with artenimol, as it does not absorb in the range of 290-700 nm. Piperaquine has an absorption maximum at 352 nm.
Danish: Ingen overvejelse af artenimols fototoksicitet er nødvendigt, da det ikke absorberer i intervallet 290-700 nm.
English: Package leaflet: information for the user Eurartesim 160 mg/20 mg film-coated tablets
Danish: Indlægsseddel: Information til brugeren Eurartesim 160 mg/20 mg filmovertrukne tabletter
English: Vomiting when taking this medicine
Danish: Opkastning efter indtagelse af denne medicin
English: Convulsion Headache
Danish: Kramper Hovedpine
English: Package leaflet: information for the user Eurartesim 320 mg/40 mg film-coated tablets
Danish: Indlægsseddel: Information til brugeren Eurartesim 320 mg/40 mg filmovertrukne tabletter
English: • Inhibition of haem-digestion pathway in the parasite food vacuole.
Danish: • Hæmning af hæmgruppens nedbrydningsvej i parasittens fødevakuole.
English: Film coating Hypromellose (E464) Titanium dioxide (E171) Macrogol 400
Danish: Filmovertræk Hypromellose (E464), titandioxid (E171), macrogol 400.
English: Concomitant treatment with such medicinal products is not recommended.
Danish: Koncentrationen af artenimol kan også være reduceret.Samtidig behandling med sådanne lægemidler anbefales ikke.
English: In patients, mean Cmax (CV%) and AUCINF of artenimol (observed after the first dose of Eurartesim) were 752 (47%) ng/ml and 2,002 (45 %) ng/ml*h, respectively.
Danish: Hos patienter var den gennemsnitlige Cmax (CV %) og AUCINF af artenimol (observeret efter den første dosis Eurartesim) hhv. 752 (47 %) ng/ml og 2002 (45 %) ng/ml*t.
English: Thrombocythaemia Splenomegaly Lymphadenopathy Hypochromasia
Danish: Trombocytæmi Splenomegali Lymfadenopati Hypokromasi
English: 5 to less than 7 Half 160 mg/20 mg tablet a day
Danish: 5 til under 7 En halv 160 mg/20 mg tablet dagligt
English: Delayed Haemolytic Anaemia
Danish: Forsinket hæmolytisk anæmi
English: In clinical trials with Eurartesim limited ECGs were obtained during treatment.
Danish: Ved kliniske undersøgelser af Eurartesim blev et begrænset antal af patienter monitoreret med EKG.
English: Eurartesim 160 mg/20 mg film-coated tablets.
Danish: Eurartesim 160 mg/20 mg filmovertrukne tabletter.
English: There are no specific data relating to the effects of piperaquine on fertility, however, to date no adverse events have been reported during clinical use.
Danish: Der foreligger ingen specifikke data angående virkningen af piperaquin på fertilitet.
English: Piperaquine is a mild inhibitor of CYP3A4.
Danish: Piperaquin er en svag hæmmer af CYP3A4.
English: Hepatomegaly Abnormal liver function tests
Danish: Hepatomegali Unormale leverfunktionsprøver Gulsot
English: Eurartesim 320 mg/40 mg film-coated tablets.
Danish: Eurartesim 320 mg/40 mg filmovertrukne tabletter.
English: 12 tablets
Danish: 12 tabletter
English: Respiratory tract infection Ear infection
Danish: Luftvejsinfektion Øreinfektion
English: 3 x 320 mg / 40 mg tablets 4 x 320 mg / 40 mg tablets
Danish: 3 x 320 mg / 40 mg tabletter 4 x 320 mg / 40 mg tabletter
English: A tabular overview of the frequency of the ADRs in paediatric patients is given below.
Danish: En oversigt over bivirkningshyppighed hos pædiatriske patienter er opstillet i tabelform herunder.
English: Moreover, from in vitro and in vivo data in animals, piperaquine and artenimol tend to accumulate in RBC.
Danish: Ydermere har piperaquin og artenimol en tendens til at akkumuleres i de røde blodlegemer (RBC), set fra in vitro og in vivo data hos dyr.
English: Piperaquine tetraphosphate/artenimol
Danish: Piperaquintetrafosfat/artenimol
English: Tel: +39 051 6489602
Danish: Tlf.: +39 051 6489602
English: Abnormalities in red blood cells, excessive numbers of platelets, enlargement of some organs (such as liver or spleen), swollen lymph glands, convulsions (fits), headache, abnormal heart sounds (heard by your doctor with a stethoscope), nose bleeds, runny nose, nausea, inflammation of the mouth, inflammation or enlargement of the liver, jaundice, abnormal liver function blood tests, skin itching and inflammation, pain in the joints.
Danish: Ikke almindelig (kan forekomme hos op til 1 ud af 100 personer) Forstyrrelser af røde blodlegemer, et for stort antal blodplader, forstørrelser af nogle organer (såsom leveren eller milten), hævede lymfeknuder, krampeanfald, hovedpine, unormale hjertelyde (som din læge har hørt med et stetoskop), næseblod, rindende næse, kvalme, mundbetændelse, forstørrelse af leveren, gulsot, unormale leverfunktionsblodprøver, hudkløe og betændelse, smerter i leddene.
English: tacrolimus); - sex hormones, including those contained in hormonal contraceptives (such as gestodene,
Danish: - medicin, der anvendes efter organtransplantation og ved autoimmunsygdomme (såsom cyclosporin, tacrolimus), - kønshormoner, herunder dem, der findes i hormonale præventionsmidler (såsom gestoden,
English: − and also pentamidine and saquinavir.
Danish: - imidazol og triazol antimykotika - samt pentamidin og saquinavir).
English: These include some of the types of medicines used to treat bacterial infections (macrolides [such as erythromycin or clarithromycin] and fluoroquinolones [such as moxifloxacin and sparfloxacin]) or fungal infections (including fluconazole and imidazole) as well as pentamidine (used to treat a specific type of pneumonia) and saquinavir (for treatment of HIV); antihistamines used to treat allergies or inflammation such as terfenadine, astemizole or mizolastine; certain medicines used to treat stomach problems such as cisapride, domperidone or droperidol; other medicines such as vinca alkaloids and arsenic trioxide (used to treat certain cancers), bepridil (used to treat angina), diphemanil (used to treat stomach disturbances), levomethadyl and methadone (used to treat drug addiction), and probucol (used to treat high blood cholesterol levels).
Danish: Disse omfatter nogle former for medicin, der anvendes til at behandle bakterielle infektioner (makrolider [såsom erythromycin eller clarithromycin] og fluoroquinoloner [såsom moxifloxacin og sparfloxacin]), eller svampeinfektioner (herunder fluconazol og imidazol) samt pentamidin (anvendes til at behandle en specifik form for lungebetændelse) og saquinavir (til behandling af HIV), antihistaminer, der anvendes til at behandle allergier eller betændelse, såsom terfenadin, astemizol eller mizolastin, visse former for medicin, der anvendes til at behandle maveproblemer, såsom cisaprid, domperidon eller droperidol, anden medicin, såsom vinca alkaloider og arseniktrioxid (anvendes til at behandle visse former for kræft), bepridil (anvendes til at behandle angina), diphemanil (anvendes til at behandle maveforstyrrelser), levomethadyl og methadon (anvendes til at behandle afhængighed af lægemidler) og probucol (anvendes til at behandle høje niveauer af kolesterol i blodet).
English: Hepatobiliary disorders
Danish: Hepatomegali Unormale leverfunktionsprøver
English: Anaemia, headache, heart rhythm disturbances (ECG changes or noticing unusually fast heart beats or palpitations), fever, general weakness.
Danish: Almindelig (kan forekomme hos op til 1 ud af 10 personer) Anæmi, hovedpine, forstyrrelser af hjerterytmen (EKG-ændringer eller registrering af usædvanligt hurtigt hjerteslag eller hjertebanken), feber, generaliseret svaghed.
English: 9 tablets
Danish: 9 tabletter
English: 7 to less than 13 One 160 mg/20 mg tablet a day
Danish: 7 til under 13 En 160 mg/20 mg tablet dagligt
English: Influenza, respiratory infections, poor appetite or loss of appetite, dizziness, convulsions (fits), irregular or slow heart rate, cough, vomiting, abdominal pain, diarrhoea, nausea, inflammation or enlargement of the liver, abnormal liver function tests, itching, pain in the muscles or joints.
Danish: Ikke almindelig (kan forekomme hos op til 1 ud af 100 personer) Influenza, luftvejsinfektion, dårlig appetit eller mangel på appetit, svimmelhed, krampeanfald, uregelmæssig eller langsom puls, hoste, opkastning, mavesmerter, diarré, kvalme, betændelse eller forstørrelse af leveren, unormale leverfunktionsprøver, kløe, smerter i muskler eller led.
English: tablets.
Danish: Tabletkerne
English: >12 to ≤18 years >18 to ≤64 years DM04011 (n=1524) ≤1 year >1 to ≤2 years
Danish: ≤5 år >5 til ≤12 år >12 til ≤18 år >18 til ≤64 år
English: progesterone, estradiol), testosterone; - glucocorticoids (hydrocortisone, dexamethasone); - omeprazole (used to treat diseases related to gastric acid production); - paracetamol (used to treat pain and fever); - theophylline (used to improve bronchial air flow); - nefazodone (used to treat depression); - aprepitant (used to treat nausea); - some gases (such as enflurane, halothane and isoflurane) used to give a general anaesthetic.
Danish: progesteron, østradiol), testosteron, - glukokortikoider (hydrokortison, dexamethason), - omeprazol (anvendes til at behandle sygdomme relateret til produktionen af mavesyre), - paracetamol (anvendes til at behandle smerter og feber), - theophyllin (anvendes til at forbedre den bronkiale luftgennemstrømning), - nefazodon (anvendes til at behandle depression), - aprepitant (anvendes til at behandle kvalme),
English: Vomiting Diarrhoea Nausea
Danish: Opkastning Diarré
English: • Certain antimicrobialmedicinal products, including medicinal products of the following classes:
Danish: • Visse antimikrobielle lægemidler, herunder lægemidler fra de følgende klasser: - Makrolider (f.eks. erythromycin, clarithromycin).
English: Eurartesim 160 mg/20 mg tablets piperaquine tetraphosphate/artenimol
Danish: Eurartesim 160 mg/20 mg tabletter piperaquintetrafosfat/artenimol
English: There is potential for neurotoxicity of artemisinin derivatives in man and animals, which is strongly related to the dose, route and formulations of the different artenimol pro-drugs.
Danish: Dette er stærkt korreleret med dosis, indgivelsesvej og formuleringer af de forskellige artenimol prodrugs.
English: 9 tablets Film-coated tablets.
Danish: 9 tabletter Filmovertrukne tabletter.
English: Hypromellose (E464) Croscarmellose sodium Magnesium stearate (E572)
Danish: Prægelatiniseret stivelse, dextrin, hypromellose (E464), croscarmellose natrium, magnesiumstearat (E572).
English: Respiratory infections, ear infection, anaemia, abnormalities in various types of blood cells (white blood cells and platelets), poor appetite or loss of appetite, eye infection, heart rhythm disturbances (change as in adults, ECG changes), abdominal pain, vomiting, diarrhoea, skin inflammation, rash, general weakness.
Danish: Almindelig (kan forekomme hos op til 1 ud af 10 personer) Luftvejsinfektion, ørebetændelse, anæmi, forstyrrelser af forskellige typer blodlegemer (hvide blodlegemer og blodplader), dårlig appetit eller manglende appetit, øjenbetændelse, forstyrrelser af hjerterytmen (ændringer som for voksne, EKG-ændringer), mavesmerter, opkastning, diarré, betændelse af hud, udslæt, generaliseret svaghed.
English: Special precaution is advised in young children when vomiting, as they are likely to develop electrolyte disturbances.
Danish: Det tilrådes at tage specielle forholdsregler ved opkastning hos små børn, , da de let kan udvikle elektrolytforstyrrelse, hvilket kan forøge den QTc-forlængende virkning af Eurartesim (se pkt.
English: 2 x 320 mg / 40 mg tablets
Danish: 2 x 320 mg / 40 mg tabletter
English: 13 to less than 24 One 320 mg/40 mg tablet a day
Danish: 13 til under 24 En 320 mg/40 mg tablet dagligt
English: 6 tablets Film-coated tablets.
Danish: 6 tabletter Filmovertrukne tabletter.
English: Concomitant Medication checklist
Danish: Oversigt over indlægssedlen:
English: Eurartesim 320 mg/40 mg tablets piperaquine tetraphosphate / artenimol
Danish: Eurartesim 320 mg/40 mg tabletter piperaquintetrafosfat/artenimol
English: Asthenia Pyrexia
Danish: Asteni Pyreksi
English: In patients mean (CV%) Cmax and AUC0-24 (observed after the first dose of Eurartesim) were 179 (62%) ng/ml and 1,679 (47%) ng/ml*h, respectively.
Danish: Hos patienter var den gennemsnitlige (CV %) Cmax og AUC0-24 (observeret efter den første dosis Eurartesim) hhv. 179 (62 %) ng/ml og 1679 (47 %) ng/ml*t. På grund af den langsomme elimination akkumuleres piperaquin i plasma efter flere doser med en akkumuleringsfaktor på ca. 3.
English: Cardiac conduction disorders
Danish: Konduktanssygdomme i hjertet