FrancophonIA/ELRC3.0 huggingface dataset:
English: During the study, most subjects used concomitant MTX, with fewer reporting use of corticosteroids or NSAIDs.
Slovenian: Med študijo je večina preiskovancev sočasno uporabljala metotreksat, manj pa jih je navedlo uporabo kortikosteroidov ali NSAIDs.
English: 95% confidence intervals for the differences in change scores between methotrexate and adalimumab.
Slovenian: 95 % intervali zaupanja za razlike v spremembi ocen med metotreksatom in adalimumabom na podlagi analize rangov zoţitev sklepne špranje
English: Your doctor may recommend temporarily stopping Kromeya.
Slovenian: Vaš zdravnik bo morda priporočil začasno prenehanje uporabe zdravila Kromeya.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with the reference medicinal product containing adalimumab in one or more subsets of the paediatric population in ulcerative colitis, see section 4.2 for information on paediatric use.
Slovenian: Evropska agencija za zdravila je začasno odloţila zahtevo za predloţitev rezultatov študij z referenčnim zdravilom, ki vsebuje adalimumab za eno ali več podskupin pediatrične populacije z ulceroznim kolitisom, za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2.
English: Warning: Do not keep any unused medicine.
Slovenian: Opozorilo: Neuporabljenega zdravila ne shranjujte.
English: In case there is a need for a more rapid response to therapy with the awareness that the risk for adverse events may be higher with use of the higher induction dose, the following dose may be used:
Slovenian: V primeru, ko je potreben hitrejši odgovor na zdravljenje, z teden zavedanjem, da je tveganje za pojav neţelenih učinkov povečano ob uporabi večjega začetnega odmerka, se lahko uporabi odmerek:
English: Week 26 Week 52 p value for Standard Dose versus Low Dose comparison.
Slovenian: 26. teden 52. teden p vrednost za primerjavo standardnega odmerka proti majhnemu odmerku.
English: Formation of antiadalimumab antibodies is associated with increased clearance and reduced efficacy of adalimumab.
Slovenian: Nastanek protiteles proti adalimumabu spremljata večji očistek in manjša učinkovitost adalimumaba.
English: Failure to respond to treatment for Crohn's disease may indicate the presence of fixed fibrotic stricture that may require surgical treatment.
Slovenian: Če se bolnik ne odzove na zdravljenje Crohnove bolezni, lahko to pomeni, da ima stalno fibrotično strikturo, zaradi katere utegne biti potrebno kirurško zdravljenje.
English: - if you are allergic to adalimumab or any of the other ingredients of this medicine (listed in section 6).
Slovenian: - če ste alergični na adalimumab ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Patients in clinical response (decrease in CDAI ≥ 70) at week 4 were stratified and analysed separately from those not in clinical response at week 4.
Slovenian: Bolnike s kliničnim odzivom (zmanjšanje CDAI ≥ 70) v 4. tednu so preučili in analizirali ločeno od tistih brez kliničnega odziva v 4. tednu.
English: • On rare occasions, treatment with Kromeya could result in lupus-like syndrome.
Slovenian: • V redkih primerih lahko zdravljenje z zdravilom Kromeya povzroči lupusu podoben sindrom.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT
Slovenian: VSEBINA, IZRAŢENA Z MASO, PROSTORNINO ALI ŠTEVILOM ENOT
English: The other cases represented a variety of different malignancies and included rare malignancies usually associated with immunosuppression.
Slovenian: Drugi primeri so obsegali številne različne malignome, med njimi redke malignome, ki so ponavadi povezani z imunosupresijo.
English: Your doctor may prescribe another strength of Kromeya if your child needs a different dose.
Slovenian: Zdravnik lahko predpiše vašemu otroku drugo jakost zdravila Kromeya, če vaš otrok potrebuje drugačen odmerek.
English: Full instructions for use are provided in the package leaflet.
Slovenian: Podrobna navodila za uporabo so navedena v navodilu za uporabo.
English: It can now be thrown away in the sharps container.
Slovenian: Sedaj jo lahko zavrţete v zbiralnik za ostre predmete.
English: BCVA was either improved or maintained (< 5 letters deterioration) in 88.4% of the eyes at week 78.
Slovenian: Najboljša korigirana ostrina vida se je ali izboljšala ali pa ohranila (poslabšanje ostrine vida < 5 črk) pri 88,4 % očeh v 78. tednu.
English: During the withdrawal period, symptoms of psoriasis returned over time with a median time to relapse (decline to PGA “moderate” or worse) of approximately 5 months.
Slovenian: Med obdobjem prenehanja uporabe so se simptomi psoriaze sčasoma znova pojavili; mediani čas do ponovitve simptomov psoriaze (relapsa) (poslabšanje na PGA "zmerno" ali slabše) je bil pribliţno 5 mesecev.
English: Percent change in total fingernail NAPSI (%)
Slovenian: Odstotek spremembe v celotnem indeksu NAPSI
English: • Children are not allowed to inject themselves and injection must be done by a trained adult.
Slovenian: • Otroci si zdravila ne smejo injicirati sami, temveč jim ga mora injicirati usposobljena odrasla oseba.
English: Adalimumab concentrations in the synovial fluid from several rheumatoid arthritis patients ranged from 31-96% of those in serum.
Slovenian: Koncentracije adalimumaba v sinovijski tekočini več bolnikov z revmatoidnim artritisom so bile od 31 do 96 % tistih v serumu.
English: No dose adjustment is required.
Slovenian: Starejši Prilagoditev odmerka ni potrebna.
English: Of the 371 remaining patients, 276 evaluable patients reached 78 weeks of open-label adalimumab treatment.
Slovenian: Od preostalih 371 bolnikov je 276 ovrednotenih bolnikov zaključilo 78. tedensko odprto zdravljenje z adalimumabom.
English: In general, the adverse events in paediatric patients were similar in frequency and type to those seen in adult patients.
Slovenian: Na splošno so bili neţeleni učinki pri pediatričnih bolnikih po pogostnosti in vrsti podobni neţelenim učinkom, opaţenih pri odraslih bolnikih.
English: Other medicines and Kromeya
Slovenian: Druga zdravila in zdravilo Kromeya
English: Detailed instructions on how to inject Kromeya are provided in section 7 ‘Instructions for use'.
Slovenian: Podrobnejše informacije kako injicirati zdravilo Kromeya so opisane v poglavju 7 “Navodila za uporabo”.
English: Refer to package leaflet for alternative storage details.
Slovenian: Za podrobnosti alternativnega shranjevanja glejte navodilo za uporabo.
English: Exposure-response relationship in paediatric population
Slovenian: Razmerje med izpostavljenostjo in odzivom pri pediatrični populaciji
English: Corticosteroids or other medicines that influence the immune system may be continued while using Kromeya.
Slovenian: Kortikosteroidi ali druga zdravila, ki zavirajo imunski sistem, se lahko še nadalje uporabljajo ob uporabi zdravila Kromeya.
English: After doses of 0.5 mg/kg (~40 mg), clearances ranged from 11 to 15 mL/hour, the distribution volume (Vss) ranged from 5 to 6 litres and the mean terminal phase half-life was approximately two weeks.
Slovenian: Po odmerkih 0,5 mg/kg (~40 mg) je bil očistek od 11 do 15 ml/uro, volumen distribucije (Vss) od 5 do 6 litrov in povprečni razpolovni čas terminalne faze pribliţno dva tedna.
English: The proportions of subjects with PedACR50/70/90 at week 12 and week 24 were 90.3%/61.3%/38.7% and 83.3%/73.3%/36.7%, respectively.
Slovenian: Deleţi preiskovancev s PedACR50/70/90 so bili 12. teden 90,3 %/61,3 %/38,7 % in 24. teden 83,3 %/73,3 %/36,7 %.
English: Step 2 Wash your hands
Slovenian: 2. korak Umijte si roke
English: Patients on adalimumab may receive concurrent vaccinations, except for live vaccines.
Slovenian: Bolniki, ki prejemajo adalimumab, lahko sočasno dobijo cepiva, razen ţivih cepiv.
English: • Children under 12 years of age are not allowed to inject themselves and injection must be done by a trained adult.
Slovenian: • Otroci, mlajši od 12 let, si zdravila ne smejo injicirati sami, temveč jim ga mora injicirati usposobljena odrasla oseba.
English: The apparent adalimumab plasma concentration that produces half the maximum probability of PedACR 50 response (EC50) was 3 μg/ml (95% CI: 1-6 μg/ml).
Slovenian: Navidezna koncentracija adalimumaba v plazmi, ki doseţe polovico največje verjetnosti Ped ACR 50 odziva (EC50) je bila 3 μg/ml (95% IZ: 1-6 μg/ml).
English: Note: Treatment failure at or after week 6 (study UV I), or at or after week 2 (study UV II), was counted as event.
Slovenian: Opomba: Neuspeh zdravljenja v ali po 6. tednu (študija UV I) ali v ali po 2. tednu (študija UV II) je bil štet kot dogodek.
English: PGA-F clear/minimal and ≥2-grade improvement (%)
Slovenian: PGA-F čisto/minimalno in ≥ izboljšanje za dva razreda (%)
English: An embryo-foetal developmental toxicity/perinatal developmental study has been performed in cynomolgus monkeys at 0, 30 and 100 mg/kg (9-17 monkeys/group) and has revealed no evidence of harm to the foetuses due to adalimumab.
Slovenian: Raziskava embrio-fetalne razvojne toksičnosti/perinatalnega razvoja je bila narejena pri opicah Cynomologous z odmerki 0,30 in 100 mg/kg (od 9 do 17 opic na skupino) in ni pokazala znakov okvare plodov zaradi adalimumaba.
English: • unusual infections (which include tuberculosis and other infections) that occur when resistance to disease is lowered;
Slovenian: • neobičajne okuţbe (vključujejo tuberkulozo in druge okuţbe, ki se pojavijo ob slabši telesni odpornosti na bolezen);
English: In the open-label period of the study, PASI 75 and PGA clear or minimal responses were maintained for up to an additional 52 weeks with no new safety findings.
Slovenian: V odprtem obdobju študije so se odzivi PASI 75 in PGA čisto ali minimalno ohranili še do dodatnih 52 tednov brez novih varnostnih ugotovitev.
English: HR of adalimumab vs placebo from proportional hazards regression with treatment as factor.
Slovenian: HR adalimumaba v primerjavi s placebom iz regresije proporcionalnih tveganj z zdravljenjem kot faktorjem.
English: Concomitant corticosteroids may be tapered in accordance with clinical practice starting two weeks after initiating treatment with Kromeya.
Slovenian: Kortikosteroide, ki se jih daje sočasno, se lahko postopoma ukinja v skladu s klinično prakso, z začetkom dva tedna po začetku zdravljenja z zdravilom Kromeya.
English: Take a syringe out of the original box:
Slovenian: Injekcijsko brizgo vzemite iz originalne ovojnine:
English: Healthcare professionals are asked to report any suspected adverse reactions.
Slovenian: Zdravstvene delavce naprošamo, da poročajo o katerem koli domnevnem neţelenem učinku zdravila.
English: By attaching to TNFα, Kromeya blocks its action and reduces the inflammation in these diseases.
Slovenian: Z vezavo na TNFα zdravilo Kromeya zaustavi to aktivnost in zmanjša vnetje pri teh boleznih.
English: Reactivation of hepatitis B has occurred in patients receiving a TNF-antagonist including adalimumab, who are chronic carriers of this virus (i.e. surface antigen positive).
Slovenian: Reaktivacijo hepatitisa B so opaţali pri bolnikih, ki so dobivali antagonist TNF (vključno z adalimumabom) in ki so bili kronični nosilci virusa (tj. pozitivni na površinski antigen).
English: Patients who experience insufficient response may benefit from an increase in dosage:
Slovenian: Pri bolnikih, ki se ne odzovejo zadostno, se odmerek lahko poveča:
English: Patients subsequently underwent a mandatory taper schedule, with complete corticosteroid discontinuation by week 19.
Slovenian: Bolniki so bili kasneje deleţni obveznega programa postopnega zmanjševanja, s popolno ukinitvijo kortikosteroidov do 19. tedna.
English: Erosion score JSN
Slovenian: Ocena erozij Seštevek JSN
English: Kromeya treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of conditions for which Kromeya is indicated.
Slovenian: Zdravljenje z zdravilom Kromeya mora uvesti in nadzorovati zdravnik specialist, izkušen v diagnosticiranju in zdravljenju bolezni, za katere je zdravilo Kromeya indicirano.
English: Adalimumab may cross the placenta into the serum of infants born to women treated with adalimumab during pregnancy.
Slovenian: Adalimumab lahko prehaja skozi placento v serum dojenčkov, ki so jih rodile ţenske, zdravljene z adalimumabom med nosečnostjo.
English: The Patient Reminder Cards (adult and paediatric) contain the following key elements: - infections, including tuberculosis - cancer - nervous system problems - vaccinations
Slovenian: Opozorilna kartica za bolnika (za odrasle in otroke) vsebuje naslednje ključne podatke: - okuţbe, vključno s tuberkulozo - rak - teţave ţivčnega sistema - cepljenja
English: - if your child is allergic to adalimumab or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če je vaš otrok alergičen na adalimumab ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: In patients with Crohn's disease, a reduction of the number of cells expressing inflammatory markers in the colon including a significant reduction of expression of TNFα was seen.
Slovenian: Pri bolnikih s Crohnovo boleznijo so opazili zmanjšanje števila celic, ki izraţajo vnetne označevalce v kolonu, vključno z bistvenim zmanjšanjem ekspresije TNFα.
English: • < 40 kg: 20 mg every week
Slovenian: • < 40 kg: 20 mg vsak teden
English: Ped ACR 30/50/70 responses week 48 significantly greater than those of placebo treated patients b p = 0.015
Slovenian: Odzivi »Ped ACR« 30/50/70 so bili 48. teden značilno večji kot pri bolnikih, ki so dobivali placebo b p = 0,015
English: • signs of skin cancer such as a bump or open sore that doesn't heal;
Slovenian: • znaki koţnega raka kot je bula ali odprta rana, ki se ne zaceli;
English: Population pharmacokinetic analyses with data from over 1300 RA patients revealed a trend toward higher apparent clearance of adalimumab with increasing body weight.
Slovenian: Analize populacijske farmakokinetike s podatki za več kot 1300 bolnikov z revmatoidnim artritisom so pokazale trend k večjemu navideznemu očistku adalimumaba z večanjem telesne teţe.
English: Tell your child's doctor or pharmacist if your child is taking, has recently taken or might take any other medicines.
Slovenian: Obvestite otrokovega zdravnika ali farmacevta, če vaš otrok jemlje, je pred kratkim jemal ali pa bo morda začel jemati katero koli drugo zdravilo.
English: Of the 417 subjects included in the uncontrolled long-term extension of Studies UV I and UV II, 46 subjects were regarded ineligible (e.g. developed complications secondary to diabetic retinopathy, due to cataract surgery or vitrectomy) and were excluded from the primary analysis of efficacy.
Slovenian: Od 417 bolnikov, ki so bili vključeni v nekontrolirani dolgoročni podaljšek študij UV I in UV II, je bilo 46 bolnikov neprimernih (npr. razvili so se zapleti, sekundarno ob diabetični retinopatiji zaradi kirurškega posega sive mrene ali vitrektomije) in so bili izključeni iz primarne analize učinkovitosti.
English: Via delle Magnolie 15 Loc. frazione Zona Industriale 70026 - Modugno (BA) Italy
Slovenian: Via delle Magnolie 15 Loc. frazione Zona Industriale 70026 - Modugno (BA) Italija
English: Across all indications in clinical trials patients with raised ALT were asymptomatic and in most cases elevations were transient and resolved on continued treatment.
Slovenian: Bolniki z zvišanim ALT, ne glede na indikacijo v kliničnih preskušanjih, so bili asimptomatski in v večini primerov so bila zvišanja prehodna ter so izzvenela med nadaljnjim zdravljenjem.
English: In CD study III, at week 4, 58% (499/854) of patients were in clinical response and were assessed in the primary analysis.
Slovenian: V študiji Crohnove bolezni III je bilo v 4. tednu 58 % (499/854) bolnikov klinično odzivnih in so bili ocenjeni v primarni analizi.
English: After subcutaneous administration of a single 40 mg dose, absorption and distribution of adalimumab was slow, with peak serum concentrations being reached about 5 days after administration.
Slovenian: Po subkutani uporabi enega samega 40 mg odmerka sta bili absorpcija in distribucija adalimumaba počasni in največja koncentracija v serumu je bila doseţena pribliţno 5 dni po uporabi.
English: • pain in the muscles.
Slovenian: • bolečine v mišicah.
English: Kromeya in combination with methotrexate, is indicated for:
Slovenian: Zdravilo Kromeya je v kombinaciji z metotreksatom indicirano za:
English: Via delle Magnolie 15 I-70026 Modugno (Bari) Italy
Slovenian: Via delle Magnolie 15 I-70026 Modugno (Bari) Italija
English: Significant improvements at week 16 from baseline compared to placebo (Studies I and II) and MTX (study II) were demonstrated in the DLQI (Dermatology Life Quality Index).
Slovenian: Značilno izboljšanje od izhodišča do 16. tedna se je v primerjavi s placebom (študiji I in II) in metotreksatom (študija II) izkazalo v dermatološkem indeksu kakovosti ţivljenja (DLQIDermatology Life Quality Index).
English: • Stevens-Johnson syndrome (life-threatening reaction with flu-like symptoms and blistering rash);
Slovenian: • sindrom Stevens-Johnson (ţivljenjsko ogroţajoča reakcija z gripo podobnimi simptomi in mehurjastimi izpuščaji);
English: Thus additional caution should be exercised in considering Kromeya treatment of these patients (see section 4.8).
Slovenian: Torej je potrebna dodatna previdnost, kadar razmišljamo o zdravljenju z zdravilom Kromeya pri teh bolnikih (glejte poglavje 4.8).
English: Moderate to severe heart failure (NYHA class III/IV) (see section 4.4).
Slovenian: Zmerno do hudo srčno popuščanje (razred III/IV po NYHA) (glejte poglavje 4.4).
English: Before initiation of therapy with Kromeya, all patients must be evaluated for both active or inactive (“latent”) tuberculosis infection.
Slovenian: Pred začetkom zdravljenja z zdravilom Kromeya je vse bolnike treba pregledati glede aktivne ali neaktivne (latentne) tuberkulozne okuţbe.
English: Fever, bruising, bleeding or looking pale
Slovenian: Vročina, podpludbe, krvavitev ali bledica
English: This will allow the needle to move up into the clear needle guard and cover the entire needle (Figure S).
Slovenian: Tako se bo injekcijska igla pomaknila v prozorno varovalo za iglo, ki jo bo v celoti prekril (Slika S).
English: Disease flare criteria were defined as a worsening of ≥ 30% from baseline in ≥ 3 of 6 Pediatric ACR core criteria, ≥ 2 active joints, and improvement of ≥ 30% in no more than 1 of the 6 criteria.
Slovenian: Merila zagona bolezni so bila opredeljena kot poslabšanje 3 od 6 osnovnih meril »Pediatric ACR« za ≥ 30 % v primerjavi z izhodiščem, ≥ 2 aktivna sklepa in izboljšanje ne več kot 1 od 6 meril za ≥ 30 %.
English: The frequency of serious infections among adalimumab treated subjects over 65 years of age (3.7%) was higher than for those under 65 years of age (1.5%).
Slovenian: Pri bolnikih nad 65 let, ki so prejemali adalimumab, je bila pogostost resnih okuţb večja (3,7 %) kot pri tistih pod 65 let starosti (1,5 %).
English: Ophthalmologists are advised to consult with an appropriate specialist before initiation of treatment with Kromeya (see section 4.4).
Slovenian: Oftalmologom se svetuje, da se pred začetkom zdravljenja z zdravilom Kromeya posvetujejo z ustreznim specialistom (glejte poglavje 4.4).
English: Clinical response * p value for Standard Dose versus Low Dose comparison.
Slovenian: Klinični odziv *p vrednost za primerjavo standardnega odmerka proti majhnemu odmerku
English: • the date
Slovenian: • datumu,
English: Note : images for illustration purposes only
Slovenian: Opomba: slike so namenjene zgolj slikovni ponazoritvi
English: • Do not give Kromeya to children with polyarticular juvenile idiopathic arthritis below the age of 2 years.
Slovenian: • Zdravila Kromeya ne smete dati otroku s poliartikularnim juvenilnim idiopatskim artritisom, če je star manj kot 2 leti.
English: Use of anti-tuberculosis prophylaxis treatment should also be considered before the initiation of Kromeya in patients with several or significant risk factors for tuberculosis despite a negative test for tuberculosis and in patients with a past history of latent or active tuberculosis in whom an adequate course of treatment cannot be confirmed.
Slovenian: O uporabi protituberkuloznega profilaktičnega zdravljenja morate pred uvedbo zdravila Kromeya razmisliti tudi pri bolnikih s hudimi ali pomembnimi faktorji tveganja za tuberkulozo kljub negativnemu testu za tuberkulozo in pri bolnikih z anamnezo latentne ali aktivne tuberkuloze, pri katerih ni mogoče potrditi ustreznega zdravljenja.
English: Kromeya should only be used during a pregnancy if needed.
Slovenian: Zdravilo Kromeya se med nosečnostjo lahko uporablja samo, če je potrebno.
English: These infections may be more serious and include tuberculosis, infections caused by viruses, fungi, parasites or bacteria, or other unusual infectious organisms and sepsis (blood poisoning).
Slovenian: Te okuţbe so lahko bolj resne in vključujejo tuberkulozo, okuţbe, ki jih povzročijo virusi, glive, paraziti ali bakterije ali druge nenavadne okuţbe organizma in sepso (zastrupitev krvi).
English: If you have moderate to severe active rheumatoid arthritis, you may first be given other disease-modifying medicines, such as methotrexate.
Slovenian: Če imate zmeren do hud aktiven revmatoidni artritis, boste morda najprej dobili druga imunomodulirajoča zdravila, npr. metotreksat.
English: Following the administration of 24 mg/m
Slovenian: Po uporabi 24 mg/m
English: Figure 2: Kaplan-Meier curves summarizing time to treatment failure on or after week 6 (study UV I) or week 2 (study UV II)
Slovenian: Slika 2: Kaplan-Meier-jeve krivulje povzemajo čas do neuspeha zdravljenja v ali po 6. tednu (študija UV I) ali 2. tednu (študija UV II)
English: The active ingredient in Kromeya, adalimumab, is a monoclonal antibody.
Slovenian: Učinkovina v zdravilu Kromeya, adalimumab, je monoklonsko protitelo.
English: In patients who develop HBV reactivation, Kromeya should be stopped and effective anti-viral therapy with appropriate supportive treatment should be initiated.
Slovenian: Pri bolnikih, ki se jim pojavi reaktivacija HBV, je treba uporabo zdravila Kromeya prekiniti in uvesti učinkovito protivirusno terapijo z ustreznim podpornim zdravljenjem.
English: Similar trends (not all statistically significant) were seen in the smaller randomised, double−blind, placebo−controlled AS study II of 82 adult patients with active ankylosing spondylitis.
Slovenian: Podobni trendi (ki pa niso bili vsi statistično značilni) so bili opazni v manjši, randomizirani, dvojno slepi, s placebom kontrolirani študiji pri ankilozirajočem spondilitisu II pri 82 odraslih bolnikih z aktivnim ankilozirajočim spondilitisom.
English: Consequently, these infants may be at increased risk for infection.
Slovenian: Posledično je lahko tveganje za okuţbe pri teh dojenčkih večje.
English: Plaque psoriasis can also affect the nails, causing them to crumble, become thickened and lift away from the nail bed which can be painful.
Slovenian: Psoriaza v plakih lahko vpliva tudi na nohte, zaradi česar se le-ti lomijo, postanejo debelejši in se dvignejo od svojega leţišča, kar je lahko boleče.
English: - if your child has moderate or severe heart failure.
Slovenian: • če ima vaš otrok zmerno ali hudo srčno popuščanje.
English: Population pharmacokinetic and pharmacokinetic/pharmacodynamic modelling and simulation predicted comparable adalimumab exposure and efficacy in patients treated with 80 mg every other week when compared with 40 mg every week (including adult patients with RA, HS, UC, CD or Ps, patients with adolescent HS, and paediatric patients ≥ 40 kg with CD).
Slovenian: Populacijsko farmakokinetično in farmakokinetično/farmakodinamično modeliranje in simulacija so za adalimumab napovedali primerljivo izpostavljenost in učinkovitost pri bolnikih, zdravljenih z 80 mg vsak drugi teden v primerjavi s 40 mg vsak teden (vključno z odraslimi bolniki z RA, HS, UC, CD ali Ps, mladostniki s HS in pediatričnimi bolniki ≥ 40 kg s CD).
English: Adalimumab binds specifically to TNF and neutralises the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
Slovenian: Adalimumab se specifično veţe na TNF in nevtralizira njegovo biološko delovanje, ker zavre njegovo interakcijo z receptorji p55 in p75 za TNF na površini celic.