FrancophonIA/ELRC3.0 huggingface dataset:
English: Hepatic disease does not significantly affect the pharmacokinetics of hydrochlorothiazide.
Danish: Leversygdommme påvirker ikke signifikant farmakokinetikken for hydrochlorthiazid.
English: Preventive measures include withdrawing or temporarily withholding diuretics, beginning therapy with very small doses of ACE inhibitors, and cautious dose titration.
Danish: Forebyggende foranstaltninger omfatter seponering eller midlertidig afbrydelse af diuretikabehandling, iværksættelse af behandling med meget små doser ACE-hæmmer samt forsigtig dosistitrering.
English: Hypokalaemia, hyponatraemia, hypochloraemia, hypomagnesaemia, hypercalcaemia, hypocalciuria, hypovolaemia/dehydration, metabolic alkalosis, hyperglycaemia, hyperuricaemia, gout, hypercholesterolaemia (increased total, LDL and VLDL cholesterol) hypertriglyceridaemia.
Danish: Hypokaliæmi, hyponatriæmi, hypochloræmi, hypomagnesiæmi, hypercalcæmi, hypocalcuri, hypovolæmi/dehydrering, metabolisk alkalose, hyperglykæmi, hyperuricæmi, artritis urica, hyperkolesterolæmi (øget total, LDL- og VLDL-kolesterol), hypertriglyceridæmi.
English: As with other agents acting on the renin-angiotensin system, there is an increased risk of renal insufficiency, including acute renal failure, when patients with renal artery stenosis are treated with cilazapril.
Danish: Som ved andre lægemidler, der virker på renin-angiotensin-systemet, er der en øget risiko for nyreinsufficiens, inklusive akut nyreinsufficiens, hvis patienter med nyrearteriestenose behandles med cilazapril.
English: Preclinical studies on the effect on fertility were not conducted with the fixed combination of cilazapril and hydrochlorothiazide.
Danish: Prækliniske studier af effekten på fertilitet blev ikke udført med den fastlagte kombination af cilazapril og hydrochlorthiazid.
English: ACE inhibitors should be used with caution in patients with obstructive cardiac disorders (e.g. mitral stenosis, aortic stenosis, hypertrophic cardiomyopathy), since cardiac output cannot increase to compensate for systemic vasodilation, and there is a risk of severe hypotension.
Danish: ACE-hæmmere skal bruges med forsigtighed hos patienter med obstruktive hjertesygdomme (f.eks. mitralstenose, aortastenose, hypertrofisk kardiomyopati), da det kardiale output ikke kan øges for at kompensere for systemisk vasodilatation, og der er risiko for svær hypotension.
English: Thiazides cross the placenta and may be associated with neonatal jaundice, thrombocytopenia and electrolyte abnormalities.
Danish: Thiazider passerer placenta og kan være forbundet med neonatal gulsot, trombocytopeni og elektrolytforstyrrelser.
English: The use of ACE inhibitors such as cilazapril is contraindicated during the second and third trimester of pregnancy (see sections 4.3 and 4.4).
Danish: Brug af ACE hæmmere som cilazapril er kontraindiceret under andet og tredje trimester af graviditeten (se pkt.
English: Rarely, neutropenia and agranulocytosis have been associated with both thiazides and ACE inhibitors, especially in patients with renal failure or collagen vascular disease, and those receiving immunosuppressive therapy.
Danish: Neutropeni og agranulocytose er i sjældne tilfælde blevet relateret til både thiazider og ACEhæmmere, især hos patienter med nyreinsufficiens eller kollagen vaskulær sygdom og patienter, som får immunsuppressiv behandling.
English: Angioedema due to ACE inhibitors can present as recurrent episodes of facial swelling, which resolves on withdrawal, or as acute oropharyngeal edema and airways obstruction, which requires emergency treatment, and may be life-threatening.
Danish: Angioødem forårsaget af ACE-hæmmere kan vise sig ved tilbagevendende episoder med ansigtshævelse, som fortager sig efter seponering, eller som akut orofaryngealt ødem og luftvejsobstruktion, som kræver akut behandling, og som kan være livstruende.
English: Thiazides may decrease urinary calcium excretion and cause elevation of serum calcium levels, and should be discontinued before carrying out tests for parathyroid function.
Danish: Thiazider kan formindske calciumudskillelsen via urinen og forårsage stigning af serum-calcium og bør seponeres før udførelse af parathyreoideafunktionstest.
English: Tricyclic antidepressants/antipsychotics/anesthetics/narcotics Concomitant use of certain anesthetic medicinal products, tricyclic antidepressants and antipsychotics with ACE inhibitors may result in further reduction of blood pressure (see section 4.4).
Danish: Tricykliske antidepressiva/antipsykotika/anæstetika Samtidig brug af visse anæstetika, tricykliske antidepressiva og antipsykotika sammen med ACEhæmmere kan medføre yderligere blodtryksfald (se pkt.
English: - if you are allergic (hypersensitive) to medicines similar to Vascace Plus such as other ACE inhibitors, other thiazide diuretics or sulphonamides.
Danish: - hvis du er allergisk (overfølsom) over for medicin, som ligner Vascace Plus, såsom andre ACEhæmmere eller thiazid-diuretika eller sulfonamider.
English: Hydrochlorothiazide belongs to a group of medicines called ‘thiazide diuretics' or ‘water tablets'.
Danish: Hydrochlorthiazid tilhører en gruppe lægemidler kaldet thiazid-diuretika eller vanddrivende medicin.
English: • Class III antiarrhythmics (e.g. amiodarone, sotalol, defetilide, ibutilide)
Danish: • Klasse III antiarytmika (f.eks. amiodaron, sotalol, defetilid, ibutilid)
English: First-dose hypotension is most likely to occur in patients whose renin-angiotensin-aldosterone system is activated, such as in renovascular hypertension or other causes of renal hypoperfusion, sodium or volume depletion, or previous treatment with other vasodilators.
Danish: Hypotension i forbindelse med første dosis er mest sandsynlig hos patienter med et aktiveret renin-angiotensinaldosteron-system, som f.eks. ved renovaskulær hypertension eller andre årsager til renal hypoperfusion, natrium- eller væskemangel eller tidligere behandling med andre vasodilatatorer.
English: Cilazapril was not teratogenic in rats and cynomolgus monkeys.
Danish: Cilazapril var ikke teratogent hos rotter og cynomolgusaber.
English: In patients with mild renal impairment, the dosage of cilazapril should be adjusted according to creatinine clearance.
Danish: Hos patienter med let nedsat nyrefunktion skal cilazaprildosis justeres i henhold til kreatininclearance.
English: The signs include swelling of the face, lips, mouth or tongue.
Danish: Symptomerne omfatter hævelse af ansigt, læber, mund eller tunge.
English: ACE inhibitors have established renoprotective effects, but can cause reversible impairment of renal function in the setting of reduced renal perfusion, whether due to bilateral renal artery stenosis, severe congestive heart failure, volume depletion, hyponatraemia or high dosages of diuretics, and in those receiving treatment with NSAIDs.
Danish: ACE-hæmmere har en veletableret renoprotektiv virkning, men kan forårsage reversibel nedsættelse af nyrefunktionen ved nedsat renal perfusion, uanset om det er forårsaget af bilateral nyrearteriestenose, alvorlig kongestiv hjerteinsufficiens, volumendepletion, hyponatriæmi eller høje doser diuretika, og hos patienter i behandling med NSAID.
English: • Other medicinal products (e.g. bepridil, cisapride, diphemanil, halofantrine, ketanserin, pentamidine, terfenadine)
Danish: • Andre lægemidler (f.eks. bepridil, cisaprid, diphemanil, halofantrin, ketanserin, pentamidin,
English: Interactions mainly related to hydrochlorothiazide
Danish: Interaktioner hovedsageligt relateret til hydrochlorthiazid Digoxin
English: Renal excretion of hydrochlorothiazide is reduced in patients with impaired renal function.
Danish: Den renale udskillelse af hydrochlorthiazid er reduceret hos patienter med nedsat nyrefunktion.
English: Adverse reactions to cilazapril
Danish: Bivirkninger for cilazapril
English: Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitors.
Danish: Der er rapporteret reversible stigninger i serum-lithium og lithiumtoksicitet ved samtidig administration af lithium og ACE-hæmmere.
English: Headache is a commonly reported adverse event, although the incidence of headache is greater in patients receiving placebo than in those receiving cilazapril + hydrochlorothiazide.
Danish: Hovedpine er rapporteret som almindelig bivirkning, selvom incidensen af hovedpine er højere hos patienter, som får placebo, end hos dem, som får cilazapril + hydrochlorthiazid.
English: When concomitant diuretic therapy is required in patients with severe renal impairment, a loop diuretic rather than a thiazide diuretic is preferred for use with cilazapril.
Danish: Hvis samtidig behandling med diuretikum er påkrævet hos patienter med alvorligt nedsat nyrefunktion, bør et loop-diuretikum i kombination med cilazapril foretrækkes frem for et thiaziddiuretikum.
English: The acute oral toxicity of cilazapril in mice was not enhanced by the combination with hydrochlorothiazide.
Danish: Den akutte orale toksicitet af cilazapril hos mus blev ikke forstærket ved kombination med hydrochlorthiazid.
English: In predisposed patients (e.g. prostatic hyperplasia) hydrochlorothiazide overdose may induce acute urinary retention.
Danish: Hos prædisponerede patienter (f.eks. med prostatahyperplasi) kan overdosering med hydrochlorthiazid forårsage akut urinretention.
English: Cytotoxic drugs (e.g. methotrexate, cyclophosphamide) Simultaneous administration of hydrochlorothiazide and cytotoxic drugs may decrease the elimination of the cytotoxic drug and consequently increase the risk of developing myelodepression.
Danish: Cytotoksiske lægemidler (f.eks. methotrexat, cyclophosphamid) Samtidig administration af hydrochlorthiazid og cytotoksiske lægemidler kan nedsætte eliminationen af det cytotoksiske lægemiddel og dermed øge risikoen for udvikling af knoglemarvsdepression.
English: Unless continued therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Danish: Medmindre fortsat behandling anses for nødvendig, skal patienter, som planlægger graviditet, skiftes over til antihypertensive regimer med en fastslået sikkerhedsprofil ved brug under graviditet.
English: - if you have porphyria.
Danish: - hvis du har urinsyregigt - hvis du har porfyri
English: Cilazapril may be continued once the patient is volume replete, but should be given at a lower dose or discontinued if hypotension persists.
Danish: Behandlingen med cilazapril kan fortsætte, når patienten er hydreret, men der bør anvendes en lavere dosis, og behandlingen bør seponeres ved persisterende hypotension.
English: - if you have kidney problems or have a problem with the blood supply to your kidneys called renal artery stenosis.
Danish: - hvis du har nyreproblemer eller har problemer med blodtilførslen til nyrerne, hvilket kaldes nyrearteriestenose.
English: Combination studies with cilazapril and hydrochlorothiazide caused similar findings as observed with cilazapril alone.
Danish: Kombinationsforsøg med cilazapril og hydrochlorthiazid viste tilsvarende fund, som er observeret med cilazapril alene.
English: When pregnancy is diagnosed, treatment with ACE inhibitors should be stopped immediately, and, if appropriate, alternative therapy should be started.
Danish: Når graviditet konstateres, skal behandling med ACE-hæmmer straks stoppes og anden behandling igangsættes, hvis det er relevant.
English: Concomitant use of ACE inhibitors and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Danish: Samtidig anvendelse af ACEhæmmer og NSAID kan medføre en øget risiko for forværring af nyrefunktionen, inklusive mulig akut nyreinsufficiens og en stigning i serumkalium, især hos patienter med allerede eksisterende nedsat nyrefunktion.
English: Concomitant administration of cilazapril with hydrochlorothiazide has no effect on the bioavailability of either cilazapril or hydrochlorothiazide.
Danish: Samtidig administration af cilazapril og hydrochlorthiazid har ingen effekt på biotilgængeligheden af hverken cilazapril eller hydrochlorthiazid.
English: In patients with renal impairment, higher plasma concentrations of cilazaprilat are observed than in patients with normal renal function, since drug clearance is reduced when creatinine clearance is lower.
Danish: Der observeres højere plasmakoncentrationer af cilazaprilat hos patienter med nedsat nyrefunktion end hos patienter med normal nyrefunktion, da lægemiddelclearance er nedsat ved lavere kreatininclearance.
English: HOW TO TAKE VASCACE PLUS
Danish: SÅDAN SKAL DU TAGE VASCACE PLUS
English: This lowers your blood pressure.
Danish: Dette nedsætter blodtrykket.
English: Interstitial nephritis, renal impairment
Danish: Interstitiel nefritis, nedsat nyrefunktion
English: Neutropenia, agranulocytosis, thrombocytopenia, anaemia Immune system disorders
Danish: Neutropeni, agranulocytose, trombocytopeni, anæmi Immunsystemet
English: Impairment of Fertility
Danish: Nedsat fertilitet
English: Electrolyte and renal function should be monitored in all patients receiving Vascace Plus.
Danish: Elektrolytter og nyrefunktion bør monitoreres hos alle patienter, som får Vascace Plus.
English: Thiazides can oppose the blood glucose-lowering effect of oral hypoglycaemic agents or insulin, and may precipitate diabetes in at-risk patients.
Danish: Thiazider kan nedsætte den blodglucosesænkende effekt af orale hypoglykæmiske stoffer eller insulin og fremprovokere diabetes hos risikopatienter.
English: Vascace Plus is a combination of cilazapril and hydrochlorothiazide.
Danish: Vascace Plus er en kombination af cilazapril og hydrochlorthiazid.
English: Vascace Plus is a combination of two medicines called cilazapril and hydrochlorothiazide.
Danish: Vascace Plus er en kombination af to slags medicin kaldet cilazapril og hydrochlorthiazid.
English: What Vascace Plus contains - The active substances are cilazapril and hydrochlorothiazide - The other ingredient(s) is (are)...
Danish: YDERLIGERE OPLYSNINGER Vascace Plus indeholder: - Aktive indholdsstoffer: cilazapril og hydrochlorthiazid - Øvrige indholdsstoffer: …
English: AUC values increase proportionally for cilazaprilat and hydrochlorothiazide with increasing doses of cilazapril and hydrochlorothiazide in the combination dosage form.
Danish: AUC-værdier for cilazaprilat og hydrochlorthiazid stiger proportionalt med stigende doser af cilazapril og hydrochlorthiazid i kombinationspræparatet.
English: Symptoms associated with overdosage of ACE inhibitors may include hypotension, circulatory shock, electrolyte disturbances, renal failure, hyperventilation, tachycardia, palpitations, bradycardia, dizziness, anxiety and cough.
Danish: Symptomer forbundet med overdosering af ACE-hæmmere kan omfatte hypotension, cirkulatorisk shock, forstyrrelse af elektrolytbalancen, nyreinsufficiens, hyperventilation, takykardi, palpitationer, bradykardi, svimmelhed, angst og hoste.
English: If you take more Vascace Plus than you should, or if someone else takes your Vascace Plus tablets, talk to a doctor or go to a hospital straight away.
Danish: Hvis du har taget for mange Vascace Plus tabletter Hvis du tager flere Vascace Plus tabletter, end du skal (eller hvis en anden person tager dine Vascace Plus tabletter), skal du straks kontakte en læge eller skadestue.
English: The overall risk of adverse effects due to treatment with Vascace Plus is similar to that observed in patients receiving cilazapril monotherapy.
Danish: Den samlede risiko for bivirkninger ved behandling med Vascace Plus svarer til den, der ses hos patienter, som får cilazapril-monoterapi.
English: - Anticholinergics.
Danish: - Antikolinerge lægemidler.
English: Unless continued ACE inhibitor therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Danish: Medmindre fortsat behandling med ACE-hæmmer anses for nødvendig, skal patienter, som planlægger graviditet, skiftes over til antihypertensive regimer, som har en fastslået sikkerhedsprofil for brug under graviditet.
English: Myocardial ischaemia, angina pectoris, tachycardia, palpitations, myocardial infarction, arrhythmia Vascular disorders
Danish: Myokardieiskæmi, angina pectoris, takykardi, palpitationer, myokardieinfarkt, arytmier Vaskulære sygdomme
English: Serum electrolytes Electrolytes and renal function should be monitored in all patients receiving Vascace Plus.
Danish: Serumelektrolytter Elektrolytter og nyrefunktion bør monitoreres hos alle patienter, som får Vascace Plus.
English: Exposure to ACE inhibitor therapy during the second and third trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia).
Danish: Eksponering for ACE-hæmmere i andet og tredje trimester kan forårsage human føtotoksicitet (nedsat nyrefunktion, oligohydramnios, forsinket kranieossifikation) og neonatal toksicitet (nyreinsufficiens, hypotension, hyperkaliæmi).
English: If indicated, cilazaprilat, the active form of cilazapril, may be removed from the general circulation by haemodialysis (see section 4.4).
Danish: Hvis det er indiceret, kan cilazaprilat, den aktive form af cilazapril, fjernes fra kredsløbet ved hæmodialyse (se pkt.
English: The frequency of adverse reactions attributable to cilazapril, occurring in patients receiving combination therapy (cilazapril + hydrochlorothiazide), may differ from that seen in patients receiving cilazapril monotherapy.
Danish: Hyppigheden for bivirkninger, som tilskrives cilazapril, set hos patienter i kombinationsbehandling (cilazapril + hydrochlorthiazid), kan afvige fra, hvad der er set hos patienter, som er i behandling med cilazapril som monoterapi.
English: Thiazides increase potassium excretion and can cause hypokalaemia.
Danish: Thiazider øger kaliumudskillelsen og kan forårsage hypokaliæmi.
English: Rash, maculopapular rash, psoriaform dermatitis, psoriasis (exacerbation), lichen planus, exfoliative dermatitis, urticaria, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous pemphigoid, pemphigus, Karposi's sarcoma, vasculitis/purpura, photosensitivity reactions, alopecia, onycholysis
Danish: Udslæt, makulopapuløst udslæt, psoriaform dermatitis, psoriasis (eksacerbationer), lichen planus, eksfoliativ dermatitis, urticaria, erythema multiforme, Stevens-Johnsons syndrom, toksisk epidermal nekrolyse, bulløs pemfigoid, pemfigus, Karposis sarkom, vasculitis/purpura, lysfølsomhedsreaktioner, alopeci, onykolyse
English: Excessive lowering of blood pressure may increase the chance of heart attack or stroke in certain patients - Increased heart rate - Feeling weak - Pains in the chest - Breathing problems, including shortness of breath and tightness in the chest - A runny or blocked nose and sneezing (rhinitis) - Dry or swollen mouth - Lack of appetite - Change in the way things taste - Diarrhoea and vomiting - Skin rash (which may be severe) - Muscle cramps or pain in your muscles or joints - Impotence - Sweating more than usual - Flushing - Sleeping problems - Blood tests showing a decrease in the number of red blood cells, white blood cells or platelets
Danish: Stort blodtryksfald kan øge risikoen for hjertetilfælde eller slagtilfælde hos visse patienter - Øget puls - Svaghedsfølelse - Smerter i brystet - Vejrtrækningsproblemer, herunder stakåndethed og strammende fornemmelse i brystet - Løbenæse, stoppet næse og nysen (rhinitis) - Tør eller hævet mund - Appetitløshed - Ændret smagssans - Diarré og opkastning - Udslæt (som kan være alvorligt) - Muskelkramper eller smerter i muskler eller led - Impotens - Øget svedtendens - Rødmen - Søvnproblemer - Blodprøver, som viser nedsat antal røde blodlegemer, hvide blodlegemer eller blodplader
English: Simultaneous administration of amantidine and hydrochlorothiazide may increase possible adverse effects of amantidine.
Danish: Samtidig administration af amantadin og hydrochlothiazid kan øge eventuelle bivirkninger fra amantadin.
English: - Soreness of your tongue - Pancreatitis (inflammation of the pancreas).
Danish: (bihulebetændelse) - Ømhed på tungen - Betændelse i bugspytkirtlen (pancreatitis).
English: Administration of ACE inhibitors to patients with diabetes may potentiate the blood glucose-lowering effect of oral hypoglycaemic agents or insulin, especially in patients with renal impairment.
Danish: Administration af ACE-hæmmere til patienter med diabetes kan forstærke den blodglucosesænkende effekt af orale hypoglykæmiske stoffer eller insulin, især hos patienter med nedsat nyrefunktion.
English: There was no evidence of teratogenicity with the combination of cilazapril and hydrochlorothiazide in rats and mice.
Danish: Der var ingen evidens for teratogenicitet for kombinationen af cilazapril og hydrochlorthiazid hos rotter og mus.
English: The pharmacokinetic parameters of cilazaprilat are not altered in the presence of increasing doses of the hydrochlorothiazide component.
Danish: De farmakokinetiske parametre for cliazaprilat ændres ikke ved stigende doser af hydrochlorthiazid.
English: Simultaneous administration of cyclosporine and hydrochlorothiazide may increase the risk of developing hyperuricemia and gout-like complications.
Danish: Samtidig administration af ciclosporin og hydrochlorthiazid kan øge risikoen for udvikling af hyperurikæmi og arthritis urica-lignende komplikationer.
English: The most frequent drug-attributable adverse event observed in patients receiving thiazide monotherapy is dizziness.
Danish: Den hyppigste lægemiddelrelaterede bivirkning, som er observeret hos patienter, som får thiazidmonoterapi, er svimmelhed.
English: There was no evidence of carcinogenicity of cilazapril and no relevant findings with hydrochlorothiazide in mice and rats.
Danish: Der var ingen evidens for karcinogenicitet af cilazapril og ingen relevante fund med hydrochlorthiazid hos mus og rotter.
English: The signs include severe pain in the stomach which spreads to your back - Changes in the way your liver or kidneys work (shown in blood and urine tests) - Liver problems such as hepatitis (inflammation of the liver) or liver damage - Severe skin reactions including blistering or peeling of skin - Increased sensitivity to light - Hair loss (which may be temporary) - Loosening or separation of a nail from its bed - Breast enlargement in men - Depression - Confusion - Dry eyes - Yellow colour vision distortion
Danish: Symptomerne omfatter kraftige mavesmerter, som breder sig til ryggen - Ændringer i lever- eller nyrefunktion (ses i blod- og urinprøver) - Leverproblemer som f.eks. hepatitis (leverbetændelse) eller leverskade - Alvorlige hudreaktioner, herunder dannelse af blister eller afskalning af huden - Øget lysfølsomhed - Hårtab (som kan være midlertidig) - Løsning af negl fra neglelejet - Brystforstørrelse hos mænd - Depression - Forvirring - Tørre øjne - Gulfarvning af synet
English: Patients receiving ACE inhibitors during LDL apheresis with dextran sulphate have experienced lifethreatening anaphylaxis.
Danish: Aferese af lavdensitetslipoproteiner (LDL-kolesterol) Patienter, som får ACE-hæmmere under LDL-aferese med dextransulfat, har oplevet livstruende anafylaksi.
English: Hydrochlorothiazide should not be used for gestational oedema, gestational hypertension or pre-eclampsia due to the risk of decreased plasma volume and placental hypoperfusion, without a beneficial effect on the course of the disease.
Danish: Hydrochlorthiazid må ikke bruges mod gestationelt ødem, gestationel hypertension eller præ-eklampsi på grund af risikoen for nedsat plasmavolumen og placental hypoperfusion uden en gavnlig effekt på sygdomsforløbet.
English: - Hypersensitivity to cilazapril, other ACE inhibitors, hydrochlorothiazide, other thiazide diuretics, sulphonamides or any excipients of Vascace Plus
Danish: - Overfølsomhed over for cilazapril, andre ACE-hæmmere, hydrochlorthiazid, andre thiaziddiuretika, sulfonamider eller over for et eller flere af hjælpestofferne.