FrancophonIA/ELRC3.0 huggingface dataset:
English: Effects on haematology parameters were found in each species, including dose-related reductions in circulating leukocytes in mice and non-specific reductions of circulating leukocytes in rats; however, no evidence of bone marrow cytotoxicity was found.
Slovenian: Pri vsaki vrsti so odkrili učinke na hematološke parametre, vključno z z odmerkom povezanimi znižanji koncentracij levkocitov v obtoku pri miših in nespecifičnim znižanjem koncentracije levkocitov v obtoku pri podganah; vendar pa niso našli dokazov citotoksičnosti za kostni mozeg.
English: Potential for olanzapine to affect other medicinal products Olanzapine may antagonise the effects of direct and indirect dopamine agonists.
Slovenian: Zmožnost vplivanja olanzapina na druga zdravila Olanzapin lahko nasprotuje učinkom direktnih in indirektnih dopaminskih agonistov.
English: A decrease in the dose of olanzapine should be considered if treatment with an inhibitor of CYP1A2 is initiated.
Slovenian: Upoštevati je treba znižanje odmerka olanzapina, če se uvede zdravljenje z zaviralcem CYP1A2.
English: Hepatitis (including hepatocellular, cholestatic or mixed liver injury)11
Slovenian: Hepatitis (vključno s hepatocelularno, holestatsko ali mešano okvaro jeter)11
English: While olanzapine demonstrated anticholinergic activity in vitro, experience during the clinical trials revealed a low incidence of related events.
Slovenian: Medtem ko je olanzapin pokazal antiholinergično delovanje v pogojih in vitro, so izkušnje kliničnih preskušanj razkrile majhno incidenco s tem povezanih dogodkov.
English: The concomitant use of olanzapine with anti-Parkinsonian medicinal products in patients with Parkinson's disease and dementia is not recommended (see section 4.4).
Slovenian: Sočasna uporaba olanzapina z antiparkinsonskimi zdravili pri bolnikih s Parkinsonovo boleznijo in demenco ni priporočena (glejte poglavje 4.4).
English: Olanzapine should be used cautiously in patients who have a history of seizures or are subject to factors which may lower the seizure threshold.
Slovenian: Olanzapin je treba uporabljati previdno pri bolnikih, ki so imeli v preteklosti epileptične napade ali so podvrženi dejavnikom, ki bi lahko znižali prag za epileptične napade.
English: Olanzapine does not inhibit the main CYP450 isoenzymes in vitro (e.g. 1A2, 2D6, 2C9, 2C19, 3A4).
Slovenian: Olanzapin ne zavira glavnih izoencimov CYP450 v pogojih in vitro (npr. 1A2, 2D6, 2C9, 2C19, 3A4).
English: • of these symptoms seek medical advice immediately;
Slovenian: Če opazite katerega od teh simptomov, nemudoma poiščite zdravniško pomoč;
English: Animal behavioural studies with olanzapine indicated 5HT, dopamine, and cholinergic antagonism, consistent with the receptor-binding profile.
Slovenian: Vedenjske študije z olanzapinom na živalih so kazale na 5HT, dopaminski in holinergični antagonizem v skladu s profilom vezave na receptorje.
English: Induction of CYP1A2
Slovenian: Indukcija CYP1A2
English: In the same clinical trials, cerebrovascular adverse events (CVAE e.g., stroke, transient ischaemic attack), including fatalities, were reported.
Slovenian: V istih kliničnih preskušanjih so poročali o cerebrovaskularnih neželenih dogodkih (cerebrovascular adverse events - CVAE, npr. o možganski kapi, tranzitorni ishemični ataki), vključno s smrtnimi izidi.
English: Standard procedures for management of overdose may be indicated (i.e. gastric lavage, administration of activated charcoal).
Slovenian: Lahko so indicirani standardni postopki za zdravljenje prevelikega odmerjanja (t. j. izpiranje želodca, dajanje aktivnega oglja).
English: Cytochromes P450CYP1A2 and P450-CYP2D6 contribute to the formation of the N-desmethyl and 2-hydroxymethyl metabolites, both exhibited significantly less in vivo pharmacological activity than olanzapine in animal studies.
Slovenian: Citokroma P450-CYP1A2 in P450CYP2D6 prispevata k tvorbi N-demetilnih in 2-hidroksimetilnih metabolitov, oboji so v študijah na živalih pokazali pomembno manj farmakološke aktivnosti in vivo kot olanzapin.
English: An allergic reaction may be recognised as a rash, itching, a swollen face, swollen lips or shortness of breath.
Slovenian: Alergijsko reakcijo lahko prepoznamo kot izpuščaj, srbenje, otekel obraz, ustnice ali oteženo dihanje.
English: Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure.
Slovenian: Dodatni znaki lahko vključujejo zvišano kreatin fosfokinazo, mioglobinurijo (rabdomioliza) in akutno ledvično odpoved.
English: In cytopenic dogs, there were no adverse effects on progenitor and proliferating cells in the bone marrow.
Slovenian: Pri psih z izraženo citopenijo ni bilo neželenih učinkov na progenitorne in proliferirajoče celice v kostnem mozgu.
English: Olanzapine reduced a conditioned avoidance response, a test indicative of antipsychotic activity, at doses below those producing catalepsy, an effect indicative of motor side-effects.
Slovenian: Olanzapin je zmanjšal pogojeni umaknitveni odziv, test, ki kaže na antipsihotično delovanje, pri odmerkih, nižjih od tistih, ki povzročijo katalepsijo, učinek, ki kaže na motorične neželene učinke.
English: With long-term exposure (at least 24 weeks), 89.4 % gained ≥ 7 %, 55.3 % gained ≥ 15 % and 29.1 % gained ≥ 25%, of their baseline body weight.
Slovenian: Pri dolgoročni izpostavljenosti (najmanj 24 tednov) jih je 89,4 % pridobilo ≥ 7 %, 55,3 % ≥ 15 % in 29,1 % ≥ 25% od njihove osnovne telesne mase.
English: 12 Adverse event identified from spontaneous post-marketing reporting with frequency estimated at the upper limit of the 95 % confidence interval utilising the Olanzapine Integrated Database.
Slovenian: 12 Neželeni učinki, ugotovljeni pri spontanem poročanju v obdobju trženja s pogostostjo, ocenjeno na zgornjo mejo 95-% intervala zaupanja, določeno z uporabo integrirane baze podatkov za olanzapin.
English: Consult your doctor if your symptoms return but do not stop taking Olanzapine Mylan unless your doctor tells you to.
Slovenian: Če se simptomi povrnejo, se posvetujte z zdravnikom, vendar ne prenehajte jemati zdravila Olanzapin Mylan, če vam tega ne naroči zdravnik.
English: • A blocked intestine (Paralytic ileus)
Slovenian: • zaporo črevesa (paralitični ileus)
English: Thus no particular interaction is expected as verified through in vivo studies where no inhibition of metabolism of the following active substances was found: tricyclic antidepressant (representing mostly CYP2D6 pathway), warfarin (CYP2C9), theophylline (CYP1A2) or diazepam (CYP3A4 and 2C19).
Slovenian: Zato ni pričakovati kakega posebnega medsebojnega delovanja, kar je bilo potrjeno s študijami in vivo, kjer niso opazili nobenega zaviranja presnove naslednjih učinkovin: tricikličnih antidepresivov (ki predstavljajo predvsem pot CYP2D6), varfarina (CYP2C9), teofilina (CYP1A2) ali diazepama (CYP3A4 in 2C19).
English: High Gamma Glutamyltransferase10
Slovenian: Visoke vrednosti gama glutamiltransferaze
English: Lipid alterations
Slovenian: Spremembe lipidov
English: However, as clinical experience with olanzapine in patients with concomitant illness is limited, caution is advised when prescribing for patients with prostatic hypertrophy, or paralytic ileus and related conditions.
Slovenian: Ker so klinične izkušnje z olanzapinom pri bolnikih s sočasnimi drugimi boleznimi omejene, se priporoča previdnost pri predpisovanju bolnikom s hipertrofijo prostate ali paralitičnim ileusom in povezanimi stanji.
English: In preclinical studies, olanzapine exhibited a range of receptor affinities (Ki < 100 nM) for serotonin 5 HT2A/2C, 5 HT3, 5 HT6; dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; α1 adrenergic; and histamine H1 receptors.
Slovenian: V predkliničnih študijah je olanzapin pokazal razpon afinitet do receptorjev (Ki; < 100 nM) za serotonin 5-HT2A/2C, 5-HT3, 5-HT6; dopamin D1, D2, D3, D4, D5; holinergičnih muskarinskih receptorjev M1-M5; adrenergičnih 1; in histaminskih H1 receptorjev.
English: Symptomatic treatment and monitoring of vital organ function should be instituted according to clinical presentation, including treatment of hypotension and circulatory collapse and support of respiratory function.
Slovenian: Glede na klinično sliko je treba uvesti simptomatsko zdravljenje in spremljanje delovanja vitalnih organov, vključno z zdravljenjem hipotenzije in cirkulatorne odpovedi ter podporo dihanja.
English: Cardiovascular monitoring is necessary to detect possible arrhythmias.
Slovenian: Za odkritje možnih aritmij je nujno spremljati delovanje kardiovaskularnega sistema.
English: Patients treated with any antipsychotic medicines, including olanzapine, should be observed for signs and symptoms of hyperglycaemia (such as polydipsia, polyuria, polyphagia, and weakness) and patients with diabetes mellitus or with risk factors for diabetes mellitus should be monitored regularly for worsening of glucose control.
Slovenian: Bolnike, zdravljene s katerimkoli antipsihotikom, vključno z zdravilom olanzapinom, moramo opazovati za znake in simptome hiperglikemije (kot so polidipsija, poliurija, polifagija in šibkost) ter redno spremljati bolnike s sladkorno boleznijo ali dejavniki tveganja za sladkorno bolezen glede poslabšanja nadzora glukoze.
English: There were more smokers among subjects with cirrhosis (4/6; 67 %) than among subjects with no hepatic dysfunction (0/3; 0 %).
Slovenian: Med osebami s cirozo (4/6, 67%) je bilo več kadilcev kot med osebami brez jetrne okvare (0/3, 0%).
English: In comparator studies of one year or less duration, olanzapine was associated with a statistically significant lower incidence of treatment emergent dyskinesia.
Slovenian: V primerjalnih študijah, ki so trajale eno leto ali manj, so olanzapin povezovali s statistično značilno manjšo incidenco diskinezij, ki se pojavijo ob zdravljenju.
English: For patients who have been receiving olanzapine for treatment of manic episode, continue therapy for preventing recurrence at the same dose.
Slovenian: Pri bolnikih, ki so prejemali olanzapin za zdravljenje manične epizode, nadaljujte zdravljenje za preprečevanje ponovnega pojava bolezni z enakim odmerkom.
English: Caution should be used if olanzapine is being administered concomitantly with medicinal products known to increase QTc interval (see section 4.4).
Slovenian: Potrebna je previdnost če dajemo olanzapin sočasno z zdravili za katera je znano, da podaljšujejo QTc interval (glejte poglavje 4.4).
English: Olanzapine is well absorbed after oral administration, reaching peak plasma concentrations within 5 to 8 hours.
Slovenian: Olanzapin se po peroralnem dajanju dobro absorbira, maksimalno plazemsko koncentracijo dosega v 5 do 8 urah.
English: Only slight to moderate increase in olanzapine clearance has been observed.
Slovenian: Opažali so le blago do zmerno povečanje očistka olanzapina.
English: Very common: Elevations of hepatic aminotransferases (ALT/AST; see section 4.4).
Slovenian: Zelo pogosti: Zvišane ravni jetrnih aminotransferaz (ALT/AST; glejte poglavje 4.4) Preiskave
English: The use of olanzapine in the treatment of dopamine agonist associated psychosis in patients with Parkinson's disease is not recommended.
Slovenian: Uporaba olanzapina pri zdravljenju psihoze, povezane z dopaminskimi agonisti, pri bolnikih s Parkinsonovo boleznijo ni priporočena.
English: In clinical trials, worsening of Parkinsonian symptomatology and hallucinations were reported very commonly and more frequently than with placebo (see section 4.8), and olanzapine was not more effective than placebo in the treatment of psychotic symptoms.
Slovenian: V kliničnih preskušanjih so o poslabšanju parkinsonske simptomatike in halucinacijah poročali zelo pogosto in pogosteje kot pri placebu (glejte poglavje 4.8), olanzapin pa ni bil bolj učinkovit kot placebo pri zdravljenju psihotičnih simptomov.
English: In addition, a Single Photon Emission Computed Tomography (SPECT) imaging study in schizophrenic patients revealed that olanzapine-responsive patients had lower striatal D2 occupancy than some other antipsychoticand risperidone-responsive patients, while being comparable to clozapine-responsive patients.
Slovenian: Dodatno je SPECT (Single Photon Emission Computed Tomography) slikovna študija pri bolnikih s shizofrenijo razkrila, da so imeli bolniki, ki so se odzivali na olanzapin, nižjo zasedenost striatnih D2 receptorjev kot bolniki, ki so se odzivali na nekatere druge antipsihotike in risperidon, medtem ko je bila primerljiva z bolniki, ki so se odzivali na klozapin.
English: The predominant pharmacologic activity is from the parent olanzapine.
Slovenian: Prevladujoča farmakološka aktivnost izvira iz samega olanzapina.
English: • The use of Olanzapine Mylan in elderly patients with dementia is not recommended as it may have serious side effects.
Slovenian: - Uporaba zdravila Olanzapin Mylan ni priporočljiva pri starejših bolnikih z demenco, saj lahko povzroči resne neželene učinke.
English: 2 Mean increases in fasting lipid values (total cholesterol, LDL cholesterol, and triglycerides) were greater in patients without evidence of lipid dysregulation at baseline.
Slovenian: 2 Povprečna povišanja vrednosti lipidov na tešče (celokupni holesterol, LDL holesterol in trigliceridi) so bila večja pri bolnikih brez očitne slabe regulacije lipidov na osnovi.
English: Do not use this medicine after the expiry date, which is stated on the carton or label after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli ali nalepki poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Patients treated with any antipsychotic medicines, including olanzapine, should be monitored regularly for lipids in accordance with utilised antipsychotic guidelines, e.g. at baseline, 12 weeks after starting olanzapine treatment and every 5 years thereafter.
Slovenian: Bolnike, zdravljene s katerim koli antipsihotikom, vključno z zdravilom olanzapinom, moramo redno spremljati glede lipidov, v skladu z znanimi priporočili za antipsihotike, npr. na začetku zdravljenja, po 12 tednih zdravljenja z olanzapinom, nato pa na vsakih 5 let.
English: Haematologic toxicity
Slovenian: Hematološka toksičnost
English: In one clinical trial in patients with bipolar mania, valproate combination therapy with olanzapine resulted in an incidence of neutropenia of 4.1 %; a potential contributing factor could be high plasma valproate levels.
Slovenian: V enem kliničnem preskušanju pri bolnikih z bipolarno manijo, je kombinirano zdravljenje z valproatom in olanzapinom povzročilo incidenco nevtropenije 4,1 %; možen vzročni dejavnik so lahko visoke plazemske ravni valproata.
English: Olanzapine was started at 2.5 mg/day and titrated to a maximum of 15 mg/day based on investigator judgement.
Slovenian: Začetni odmerek olanzapina je bil 2,5 mg na dan in nato postopoma zviševan do najvišjega odmerka 15 mg na dan na podlagi presoje preiskovalca.
English: Olanzapine showed no interaction when co-administered with lithium or biperiden.
Slovenian: Olanzapin ni kazal interakcij ob sočasnem dajanju z litijem ali biperidenom.
English: Reproductive system and breast disorders Erectile dysfunction in males
Slovenian: Motnje reprodukcije in dojk Erektilna disfunkcija pri moških
English: Patients who have taken more olanzapine than they should have experienced the following symptoms: rapid beating of the heart, agitation/aggressiveness, problems with speech, unusual movements (especially of the face or tongue) and reduced level of consciousness.
Slovenian: Bolniki, ki so vzeli večji odmerek zdravila Olanzapin Mylan, kot bi smeli, so imeli naslednje simptome: hitro bitje srca, vznemirjenost/nasilnost, težave pri govoru, nenavadne zgibke (posebno v mišicah obraza ali jezika) in zmanjšano stopnjo zavesti.
English: Olanzapine administered with lithium or valproate resulted in increased levels (10 %) of tremor, dry mouth, increased appetite, and weight gain.
Slovenian: Olanzapin dan z litijem ali valproatom je povzročil zvišane ravni (≥ 10 %) tresenja, suhih ust, povečanega apetita in povečanja telesne mase.
English: Abdominal distension9 Pancreatitis11
Slovenian: Trebušna distenzija9 Pankreatitis11
English: The major circulating metabolite is the 10-N-glucuronide, which does not pass the blood brain barrier.
Slovenian: V krvi je poglavitni metabolit 10-Nglukuronid, ki ne prehaja skozi krvno-možgansko pregrado.
English: Deutschland Mylan Healthcare GmbH Tel: +49 800 0700 800
Slovenian: Mylan Healthcare GmbH Tel: +49 800 0700 800
English: • medicines for Parkinson's disease.
Slovenian: • zdravila za Parkinsonovo bolezen
English: In a multinational, double-blind, comparative study of schizophrenia, schizoaffective, and related disorders which included 1,481 patients with varying degrees of associated depressive symptoms (baseline mean of 16.6 on the Montgomery-Asberg Depression Rating Scale), a prospective secondary analysis of baseline to endpoint mood score change demonstrated a statistically significant improvement (p=0.001) favouring olanzapine (-6.0) versus haloperidol (-3.1).
Slovenian: V dvojno slepi primerjalni študiji shizofrenije, shizoafektivnih in sorodnih motenj, v kateri je sodelovalo več držav in je vključevala 1481 bolnikov z različnimi stopnjami pridruženih depresivnih simptomov (izhodiščna srednja vrednost 16,6 na Montgomery-Asbergovi lestvici ocenjevanja depresije), je prospektivna sekundarna analiza spremembe od izhodiščne do končne ocene razpoloženja pokazala statistično značilno izboljšanje (p = 0,001) v korist olanzapina (-6,0) v primerjavi s haloperidolom (-3,1).
English: Decreased bioavailability
Slovenian: Zmanjšana biološka uporabnost
English: Anticholinergic activity
Slovenian: Antiholinergično delovanje
English: The daily dose of olanzapine is between 5 mg and 20 mg.
Slovenian: Dnevni odmerek zdravila Olanzapin Mylan je med 5 mg in 20 mg.
English: Risk factors that may predispose this patient population to increased mortality include age >65 years, dysphagia, sedation, malnutrition and dehydration, pulmonary conditions (e.g., pneumonia, with or without aspiration), or concomitant use of benzodiazepines.
Slovenian: Dejavniki tveganja, ki lahko povzročijo večjo dovzetnost te skupine bolnikov za povečano umrljivost, vključujejo starost > 65 let, težave s požiranjem, sedacijo, nezadostno prehrano ali dehidracijo, obolenja pljuč (npr. pljučnica, z aspiracijo ali brez nje), ali sočasno uporabo benzodiazepinov.
English: • unusual movement (a common side effect that may affect up to 1 in 10 people) mainly of the face or tongue;
Slovenian: • nenavadne zgibke (pogost neželeni učinek, ki se lahko pojavi pri manj kot 1od 10 bolnikov), posebno mišic obraza ali jezika;
English: Studies in patients aged 13-17 years showed various adverse reactions, including weight gain, changes in metabolic parameters and increases in prolactin levels (see sections 4.8 and 5.1).
Slovenian: Študije pri bolnikih, starih 13 - 17 let kažejo na različne neželene učinke, vključno s povečanjem telesne mase, spremembami v kazalcih presnove in zvišanjih ravni prolaktina (glejte poglavji 4.8 in 5.1).
English: Pregnancy, puerperium and perinatal conditions
Slovenian: Motnje v času nosečnosti, puerperija in perinatalnem obdobju
English: In placebocontrolled clinical trials (6-12 weeks duration) of elderly patients (mean age 78 years) with dementiarelated psychosis and/or disturbed behaviours, there was a 2-fold increase in the incidence of death in olanzapine-treated patients compared to patients treated with placebo (3.5 % vs. 1.5 %, respectively).
Slovenian: V kliničnih preskušanjih, kontroliranih s placebom (ki so trajali 6 - 12 tednov), pri starejših bolnikih s psihozo, povezano z demenco in/ali vedenjskimi motnjami (povprečna starost 78 let), je bilo 2-kratno povečanje incidence smrti pri bolnikih, zdravljenih z olanzapinom, v primerjavi z bolniki, zdravljenimi s placebom (3,5 % v primerjavi z 1,5 %).
English: Oestrous cycles were affected at doses of 1.1 mg/kg (3 times the maximum human dose) and reproduction parameters were influenced in rats given 3 mg/kg (9 times the maximum human dose).
Slovenian: Odmerki 1,1 mg/kg (3-kratni maksimalni odmerek za človeka) so vplivali na estrus cikluse, odmerki 3 mg/kg (9-kratni maksimalni odmerek za človeka) pa so pri podganah vplivali na parametre reprodukcije.
English: In most of these cases, a history of seizures or risk factors for seizures were reported.
Slovenian: Pri večini teh primerov so o teh napadih poročali že v preteklosti ali so bili navzoči dejavniki tveganja za epileptični napad.
English: Sedation affected mating performance of male rats.
Slovenian: Sedacija je vplivala na uspešnost parjenja pri samcih podgan.
English: However, caution should be exercised when olanzapine is prescribed with medicines known to increase QTc interval, especially in the elderly, in patients with congenital long QT syndrome, congestive heart failure, heart hypertrophy, hypokalaemia or hypomagnesaemia.
Slovenian: Vendar pa je potrebna previdnost, kadar predpisujemo olanzapin skupaj z zdravili, za katera je znano, da podaljšujejo QTc interval, posebno pri starejših, pri bolnikih s prirojenim sindromom dolgega QT intervala, kongestivnim popuščanjem srca, hipertrofijo srca, hipokaliemijo ali hipomagnezemijo.
English: Also contains lactose monohydrate and soya lecithin.
Slovenian: SEZNAM POMOŽNIH SNOVI Vsebuje tudi laktozo monohidrat in sojin lecitin.
English: Olanzapine is metabolised in the liver by conjugative and oxidative pathways.
Slovenian: Olanzapin se presnavlja v jetrih s potmi konjugacije in oksidacije.
English: 6 In clinical trials, the incidence of Parkinsonism and dystonia in olanzapine-treated patients was numerically higher, but not statistically significantly different from placebo.
Slovenian: 6 V kliničnih preskušanjih je bila incidenca parkinsonizma in distonije pri bolnikih, zdravljenih z olanzapinom, številčno večja, a se ni statistično značilno razlikovala od placeba.
English: What Olanzapine Mylan is and what it is used for
Slovenian: Kaj je zdravilo Olanzapin Mylan in za kaj ga uporabljamo
English: • Schizophrenia, a disease with symptoms such as hearing, seeing or sensing things which are not there, mistaken beliefs, unusual suspiciousness, and becoming withdrawn.
Slovenian: • shizofrenije, bolezni s simptomi, kot so prisluhi, prividi ali občutki, ki niso povezani z realnostjo, zmotna prepričanja, nenavadna sumničavost in postopno izogibanje socialnim stikom.
English: 14 Observed for fasting normal levels at baseline (< 1.016 mmol/l) which increased to high (≥ 1.467 mmol/l) and changes in fasting triglycerides from borderline at baseline (≥ 1.016 mmol/l< 1.467 mmol/l) to high (≥ 1.467 mmol/l).
Slovenian: 14 Opazovano pri osnovnih normalnih ravneh na tešče (< 1,016 mmol/l), ki so se povišale na visoke (≥ 1,467 mmol/l) in spremembe v ravneh trigliceridov na tešče z mejnih osnovnih vrednosti (≥ 1,016 mmol/l - < 1,467 mmol/l) na visoke (≥ 1,467 mmol/l).
English: Caution should be exercised and follow-up organised in patients with elevated ALT and/or AST, in patients with signs and symptoms of hepatic impairment, in patients with pre-existing conditions associated with limited hepatic functional reserve, and in patients who are being treated with potentially hepatotoxic medicines.
Slovenian: Pri bolnikih s zvišano ALT in/ali AST, bolnikih z znaki in simptomi okvarjenega delovanja jeter, bolnikih s prej obstoječimi stanji, povezanimi z omejeno jetrno funkcionalno rezervo, in pri bolnikih, ki se zdravijo s potencialno hepatotoksičnimi zdravili, je potrebna previdnost.
English: Olanzapine is indicated for the treatment of moderate to severe manic episode.
Slovenian: Olanzapin je indiciran za zdravljenje zmerne do težke manične epizode.
English: A causal relationship between the occurrence of venous thromboembolism and treatment with olanzapine has not been established.
Slovenian: Vzročne povezave med pojavnostjo venske tromboembolije in zdravljenjem z olanzapinom niso ugotovili.
English: Hypothermia12
Slovenian: Hipotermija12
English: Olanzapine is indicated for the treatment of schizophrenia.
Slovenian: Olanzapin je indiciran za zdravljenje shizofrenije.