FrancophonIA/ELRC3.0 huggingface dataset:
English: The tablet and oral suspension are not to be used interchangeably due to the differences between these two formulations in frequency of dosing, administration with food and plasma drug concentration achieved.
Slovenian: Tablet in peroralne suspenzije se ne sme uporabljati medsebojno zamenljivo zaradi razlik med oblikama v pogostnosti odmerjanja, razlik pri uporabi s hrano in razlik v doseganju plazemskih koncentracij zdravila.
English: Posaconazole concentrate for solution for infusion safety In initial studies of healthy volunteers, administration of a single dose of posaconazole infused over 30 minutes via a peripheral venous catheter was associated with a 12 % incidence of infusion site reactions (4 % incidence of thrombophlebitis).
Slovenian: Varnost posakonazola v koncentratu za raztopino za infundiranje V prvotnih študijah pri zdravih prostovoljcih je uporabo enkratnega odmerka posakonazola, infundiranega v 30 minutah po perifernem venskem katetru, spremljala 12 % pojavnost reakcij na mestu infundiranja (4 % pojavnost tromboflebitisa).
English: Look at the list of medicines given above that must not be taken while you are taking Noxafil.
Slovenian: Preberite zgornji seznam zdravil, ki jih ne smete jemati med zdravljenjem z zdravilom Noxafil.
English: • pimozide (used to treat symptoms of Tourette's and mental illness)
Slovenian: • pimozid (za zdravljenje simptomov Tourettovega sindroma in duševnih bolezni)
English: These types of patients had been previously studied in a pivotal controlled trial of posaconazole oral suspension.
Slovenian: Te vrste bolnikov so predhodno preučevali v ključnem kontroliranem preskušanju peroralne suspenzije posakonazola.
English: Cohort 0 was designed to evaluate the tolerability of a single dose of posaconazole concentrate for solution for infusion when administered via a central line.
Slovenian: Kohorta 0 je bila namenjena za oceno prenašanja enkratnega odmerka posakonazola v koncentratu za raztopino za infundiranje, uporabljenega po centralni liniji.
English: The addition of posaconazole to therapy with atazanavir or with atazanavir plus ritonavir was associated with increases in plasma bilirubin levels.
Slovenian: Dodatek posakonazola med zdravljenjem z atazanavirjem oziroma z atazanavirjem in ritonavirjem je bil povezan s povečanjem koncentracije bilirubina v plazmi.
English: Noxafil 40 mg/mL oral suspension
Slovenian: Noxafil 40 mg/ml peroralna suspenzija
English: When Noxafil treatment is stopped by your doctor you should not experience any effects.
Slovenian: Ko zdravnik konča zdravljenje z zdravilom Noxafil, vam to ne sme povzročiti nobenih učinkov.
English: Pharmacokinetic / Pharmacodynamic relationships A correlation between total medicinal product exposure divided by MIC (AUC/MIC) and clinical outcome was observed.
Slovenian: Opazili so korelacijo med celotno izpostavljenostjo zdravilu deljeno z vrednostjo MIC (AUC/MIC) in kliničnim izidom.
English: In twelve-month neurotoxicity studies in dogs and monkeys, no functional effects were observed on the central or peripheral nervous systems at systemic exposures greater than those achieved therapeutically.
Slovenian: V 12-mesečnih študijah nevrotoksičnosti na psih in opicah niso opažali funkcionalnih učinkov na osrednje ali periferno živčevje pri sistemskih izpostavljenostih, ki so bile večje od terapevtsko doseženih izpostavljenosti.
English: One bottle of 105 mL of oral suspension.
Slovenian: Ena 105 ml steklenička peroralne suspenzije.
English: • any medicines that contain “ergot alkaloids” such as ergotamine or dihydroergotamine used to treat migraines.
Slovenian: • katerega koli zdravila, ki vsebuje alkaloide ergot (na primer ergotamin ali dihidroergotamin), ki se uporabljajo za zdravljenje migrene.
English: • patients having “high-dose immunosuppressive therapy” after “hematopoietic stem cell transplant” (HSCT).
Slovenian: • pri bolnikih, ki prejemajo visokoodmerno imunosupresijsko zdravljenje po presaditvi hematopoetskih matičnih celic (HSCT).
English: Limited data on the effect of hepatic impairment (including Child-Pugh C classification of chronic liver disease) on the pharmacokinetics of posaconazole demonstrate an increase in plasma exposure compared to subjects with normal hepatic function, but do not suggest that dose adjustment is necessary (see sections 4.4 and 5.2).
Slovenian: Majhno število podatkov o vplivu okvare jeter (vključno s kronično boleznijo jeter razreda C po klasifikaciji Child-Pugh) na farmakokinetiko posakonazola kaže na povečanje plazemske izpostavljenosti temu zdravilu v primerjavi s preiskovanci z normalnim delovanjem jeter, vendar ne nakazuje, da bi bilo treba prilagoditi odmerek (glejte poglavji 4.4 in 5.2).
English: This exposure was selected based on pharmacokinetic/pharmacodymanic considerations with posaconazole oral suspension.
Slovenian: Ta izpostavljenost je bila izbrana glede na farmakokinetiko/farmakodinamiko peroralne suspenzije posakonazola.
English: • blood problems such as unusual blood clotting or prolonged bleeding
Slovenian: • težave s krvjo, na primer motnje strjevanja krvi ali podaljšane krvavitve
English: However, the safety profile of posaconazole between the Black and Caucasian subjects was similar.
Slovenian: Vendar pa je bil varnostni profil posakonazola pri preiskovancih črne in bele rase podoben.
English: • high blood pressure in the blood vessels in the lungs (pulmonary hypertension) this can cause serious damage to your lungs and heart
Slovenian: • visok krvni tlak v pljučnih žilah (pljučna hipertenzija), ki lahko resno okvari pljuča in srce
English: Noxafil must not be administered with medicinal products that are substrates for CYP3A4 and are known to prolong the QTc interval (see sections 4.3 and 4.5).
Slovenian: Zdravila Noxafil se ne sme uporabljati skupaj z zdravili, ki so substrati CYP3A4 in za katere je znano, da podaljšajo interval QTc (glejte poglavji 4.3 in 4.5).
English: Therefore, inhibitors (e.g. verapamil, ciclosporin, quinidine, clarithromycin, erythromycin, etc.) or inducers (e.g. rifampicin, rifabutin, certain anticonvulsants, etc.) of these clearance pathways may increase or decrease posaconazole plasma concentrations, respectively.
Slovenian: Zato lahko zaviralci (npr. verapamil, ciklosporin, kinidin, klaritromicin, eritromicin, itd.) ali induktorji (npr. rifampicin, rifabutin, določeni antikonvulzivi, itd.) teh poti izločanja povečajo ali zmanjšajo koncentracije posakonazola v plazmi.
English: • have an abnormal heart rhythm tracing (ECG) that shows a problem called long QTc interval
Slovenian: • če imate nenormalen zapis srčnega ritma (EKG), ki kaže motnjo, imenovano podaljšanje intervala QTc.
English: However, in clinical efficacy trials, the safety profile of posaconazole between the young and elderly patients was similar.
Slovenian: V kliničnih preskušanjih učinkovitosti pa je bil profil varnosti posakonazola pri starostnikih podoben kot pri mlajših bolnikih.
English: • hair loss (alopecia)
Slovenian: • izpadanje las (alopecija)
English: Based on the available data in 16 of these paediatric patients, the safety profile appears to be similar to patients ≥ 18 years of age.
Slovenian: Na podlagi razpoložljivih podatkov za 16 od teh pediatričnih bolnikov je varnostni profil zdravila videti podoben kot pri bolnikih, starih ≥ 18 let.
English: No clinically relevant changes in the mean QTc (Fridericia) interval from baseline were observed.
Slovenian: V primerjavi z izhodiščem niso opazili klinično pomembnih sprememb povprečnega intervala QTc (Fridericia).
English: • adrenal glands not working properly - this may cause weakness, tiredness, loss of appetite, skin discolouration
Slovenian: • nepravilno delovanje nadledvičnih žlez - to lahko povzroči šibkost, utrujenost, izgubo apetita,
English: • some patients have also reported feeling confused after using Noxafil.
Slovenian: • nekateri bolniki so po uporabi zdravila Noxafil poročali tudi o občutku zmedenosti.
English: Based on the pharmacokinetics and safety results of Cohorts 1 and 2, all subjects in Cohort 3 received 300 mg twice daily on Day 1, followed by 300 mg once daily thereafter.
Slovenian: Na podlagi rezultatov o farmakokinetiki in varnosti v kohortah 1 in 2 so vsi preiskovanci v kohorti 3 dobili 300 mg dvakrat na dan 1. dan in nato 300 mg enkrat na dan.
English: It is particularly important to try to ensure that maximal plasma levels are achieved in patients infected with Aspergillus (see sections 4.2 and 5.2 on recommended dose regimens).
Slovenian: Posebej pomembno je, da poskušamo zagotoviti, da pri bolnikih, okuženih z Aspergillusom, dosežemo največje plazemske koncentracije (glejte poglavji 4.2 in 5.2 o priporočenih režimih odmerjanja).
English: Posaconazole is highly protein bound (> 98 %), predominantly to serum albumin.
Slovenian: Posakonazol je v veliki meri vezan na beljakovine (> 98 %), predvsem na serumski albumin.
English: Gastro-resistant tablet (tablet) Yellow-coated, capsule-shaped tablet of 17.5 mm length debossed with “100” on one side.
Slovenian: gastrorezistentna tableta (tableta) Rumena, obložena tableta v obliki kapsule, dolga 17,5 mm in z vtisnjeno oznako "100" na eni strani.
English: When initiating treatment with posaconazole in patients already receiving ciclosporin, the dose of ciclosporin should be reduced (e.g. to about three quarters of the current dose).
Slovenian: Na začetku zdravljenja s posakonazolom je treba bolnikom, ki že prejemajo ciklosporin, odmerek ciklosporina zmanjšati (npr. na približno tri četrtine trenutnega odmerka).
English: This medicinal product contains 462 mg (20 mmol) sodium per dose.
Slovenian: To zdravilo vsebuje 462 mg (20 mmol) natrija na odmerek.
English: In a study in healthy volunteers posaconazole oral suspension (200 mg once daily for 10 days) increased the exposure (AUC) of intravenous midazolam (0.05 mg/kg) by 83 %.
Slovenian: V študiji pri zdravih prostovoljcih je peroralna suspenzija posakonazola (200 mg enkrat na dan 10 dni) povečala izpostavljenost (AUC) intravensko uporabljenemu midazolamu (0,05 mg/kg) za 83 %.
English: Patients were treated with posaconazole or fluconazole oral suspension (both posaconazole and fluconazole were given as follows: 100 mg twice a day for 1 day followed by 100 mg once a day for 13 days).
Slovenian: Bolnike so zdravili s posakonazolom ali s peroralno suspenzijo flukonazola (tako posakonazol kot flukonazol so odmerjali na naslednji način: 100 mg dvakrat na dan 1 dan, potem pa 100 mg enkrat na dan 13 dni).
English: Thromboembolic events
Slovenian: Tromboembolični dogodki
English: As shown in Table 4, a successful response (complete or partial resolution) at the end of treatment was seen in 42 % of posaconazole-treated patients compared to 26 % of the external group.
Slovenian: Kot prikazuje preglednica 4, je bil uspešen odziv (popolno ali delno izginotje) ob koncu zdravljenja opazen pri 42 % bolnikov, zdravljenih s posakonazolom, in pri 26 % bolnikov iz zunanje skupine.
English: Noxafil can increase the amount of these medicines in the blood which may lead to a severe decrease in blood flow to your fingers or toes and could cause damage to them.
Slovenian: Zdravilo Noxafil lahko poveča koncentracijo teh zdravil v krvi; to lahko zelo zmanjša dotok krvi v prste rok in nog in lahko povzroči njihovo okvaro.
English: • large purple discolourations on the skin (thrombotic thrombocytopenic purpura)
Slovenian: • obsežna vijolična obarvanja kože (trombotična trombocitopenična purpura)
English: The following medicines may decrease the effectiveness of Noxafil by decreasing the amount of Noxafil in the blood:
Slovenian: Naslednja zdravila lahko zmanjšajo učinkovitost zdravila Noxafil, ker zmanjšajo njegovo količino v krvi:
English: • halofantrine (used to treat malaria)
Slovenian: • halofantrin (za zdravljenje malarije)
English: • loss of appetite, stomach pain or upset stomach, passing wind, dry mouth, changes in your taste
Slovenian: • izguba apetita, bolečine v želodcu ali razdražen želodec, vetrovi, suha usta, spremembe okusa
English: Posaconazole increased Cmax and AUC of tacrolimus (0.05 mg/kg body weight single dose) by 121 % and 358 %, respectively.
Slovenian: Posakonazol je povečal Cmax takrolimusa (enkratni odmerek 0,05 mg/kg telesne mase) za 121 % in njegovo AUC za 358 %.
English: If it is considered that co-administration is unavoidable, then it is recommended that the dose of sirolimus should be greatly reduced at the time of initiation of posaconazole therapy and that there should be very frequent monitoring of trough concentrations of sirolimus in whole blood.
Slovenian: Če se sočasni uporabi ni mogoče izogniti, je ob uvedbi zdravljenja s posakonazolom priporočljivo zelo zmanjšati odmerek sirolimusa in zelo pogosto preverjati najnižjo koncentracijo sirolimusa v polni krvi.
English: • diltiazem, verapamil, nifedipine, nisoldipine or other “calcium channel blockers” (used to treat high blood pressure)
Slovenian: • diltiazem, verapamil, nifedipin, nizoldipin in drugi zaviralci kalcijevih kanalčkov (uporabljajo se za zdravljenje visokega krvnega tlaka),
English: In subjects with severe renal impairment (n=6, Cl cr < 20 mL/min/1.73 m2), the AUC of posaconazole was highly variable [> 96 % CV (coefficient of variance)] compared to other renal groups [< 40 % CV].
Slovenian: Pri preiskovancih s hudo okvaro ledvic (n = 6, očistek kreatinina < 20 ml/min/1,73 m2) je bila AUC posakonazola močno spremenljiva [koeficient variacije (KV) > 96 %] v primerjavi z drugimi kategorijami delovanja ledvic [KV < 40 %].
English: renal tubular acidosis, interstitial nephritis
Slovenian: ledvična tubularna acidoza, intersticijski nefritis
English: Cav = the average concentration when measured at steady state *20 patients received 200 mg once daily (Day 1 200 mg twice daily)
Slovenian: Cav = povprečna koncentracija, merjena v stanju dinamičnega ravnovesja *20 bolnikov je prejemalo 200 mg enkrat na dan (200 mg dvakrat na dan 1. dan)
English: Tablet coat polyvinyl alcohol macrogol 3350 titanium dioxide (E171) talc iron oxide yellow (E172)
Slovenian: Obloga tablete polivinilalkohol makrogol 3350 titanov dioksid (E171) smukec rumeni železov oksid (E172)
English: If you forget to take Noxafil
Slovenian: Če ste pozabili vzeti zdravilo Noxafil
English: ) was prolonged from approximately 27 hours up to ~43 hours in respective groups.
Slovenian: 27 ur na vse do približno 43 ur.
English: The effect of posaconazole on CYP3A4 substrates in patients might be somewhat lower than that observed in healthy volunteers, and is expected to be variable between patients due to the variable posaconazole exposure in patients.
Slovenian: Učinek posakonazola na substrate CYP3A4 je lahko pri bolnikih nekoliko manjši kot pri zdravih prostovoljcih in mogoče je pričakovati, da se od bolnika do bolnika razlikuje zaradi različne stopnje izpostavljenosti posakonazolu.
English: Thrombophlebitis was observed in clinical trials.
Slovenian: V kliničnih preskušanjih so opazili tromboflebitis.
English: Noxafil gastro-resistant tablets are packaged in a blister in cartons of 24 (2x12) or 96 (8x12) tablets.
Slovenian: Noxafil gastrorezistentne tablete so pakirane v pretisnih omotih v škatlah, ki vsebujejo po 24 (2 x 12) ali 96 (8 x 12) tablet.
English: • severe allergic reactions, including widespread blistering rash and skin peeling
Slovenian: • hude alergijske reakcije, vključno z izpuščajem z mehurji in lupljenje kože po celem telesu
English: If not used immediately, the solution can be stored up to 24 hours refrigerated 2°C-8°C.
Slovenian: Če ni uporabljeno takoj, je mogoče raztopino shranjevati do 24 ur, shranjeno v hladilniku pri temperaturi od 2 °C do 8 °C.
English: As shown in Table 3, a successful response (complete or partial resolution) at the end of treatment was seen in 42 % of posaconazole-treated patients compared to 26 % of the external group.
Slovenian: Kot prikazuje preglednica 3, je bil uspešen odziv (popolno ali delno izginotje) ob koncu zdravljenja opazen pri 42 % bolnikov, zdravljenih s posakonazolom, in pri 26 % bolnikov iz zunanje skupine.
English: Quartile pCav Range (ng/mL)
Slovenian: Razpon pCav (ng/ml)
English: The effect of co-administration with posaconazole on plasma levels of CYP3A4 substrates may also be variable within a patient, unless posaconazole is administered in a strictly standardised way with food, given the large food effect on posaconazole exposure (see section 5.2).
Slovenian: Učinek sočasne uporabe posakonazola na plazemske koncentracije substratov CYP3A4 se lahko razlikuje tudi pri posameznem bolniku, razen če prejme posakonazol na strogo standardiziran način s hrano, glede na velik vpliv hrane na izpostavljenost posakonazolu (glejte poglavje 5.2).
English: The safety of posaconazole oral suspension has been assessed in > 2,400 patients and healthy volunteers enrolled in clinical trials and from post-marketing experience.
Slovenian: Varnost peroralne suspenzije posakonazola so ocenili pri > 2.400 bolnikih in zdravih prostovoljcih, vključenih v klinična preskušanja, in na podlagi izkušenj med obdobjem trženja.
English: Co-administration may result in increased plasma concentrations of these medicinal products, leading to QTc prolongation and rare occurrences of torsades de pointes (see section 4.3).
Slovenian: Sočasna uporaba lahko povzroči povečanje koncentracije teh zdravil v plazmi, kar vodi do podaljšanja intervala QTc in v redkih primerih povzroči torsades de pointes (glejte poglavje 4.3).
English: • swelling, redness, and tenderness along the vein in which Noxafil was given
Slovenian: • oteklost, pordelost in občutljivost vzdolž vene, v katero ste dobili zdravilo Noxafil
English: 300 mg once daily (Day 1 300 mg twice daily)*
Slovenian: 300 mg enkrat na dan (1. dan 300 mg dvakrat na dan)*
English: abnormal dreams, confusional state, sleep disorder psychotic disorder, depression
Slovenian: nenormalne sanje, zmedenost, motnje spanja psihotična motnja, depresija
English: §, electrocardiogram abnormal palpitations, bradycardia, supraventricular extrasystoles, tachycardia
Slovenian: §, nenormalen elektrokardiogram palpitacije, bradikardija, supraventrikularne ekstrasistole, tahikardija
English: Posaconazole may increase the plasma concentrations of vinca alkaloids which may lead to neurotoxicity and other serious adverse reactions.
Slovenian: Posakonazol lahko zviša plazemsko koncentracijo alkaloidov vinke kar lahko vodi do nevrotoksičnosti in drugih resnih neželenih učinkov.
English: In Table 3 a comparison is shown of exposure (Cav) after administration of posaconazole tablet and posaconazole oral suspension at therapeutic doses in patients depicted as quartile analysis.
Slovenian: Preglednica 3 prikazuje primerjavo izpostavljenosti (Cav) po uporabi tablet posakonazola in peroralne suspenzije posakonazola v terapevtskih odmerkih pri bolnikih, predstavljeno z analizo kvartilov.
English: • a change in the salt level in your blood shown in blood tests - signs include feeling confused or weak
Slovenian: • sprememba koncentracije soli v krvi, ki se pokaže na preiskavah krvi - med znaki sta občutek zmedenosti ali šibkost
English: The excreted metabolites in urine and faeces account for approximately 17 % of the administered radiolabelled dose.
Slovenian: V urinu in blatu izločeni presnovki zajemajo približno 17 % uporabljenega radioaktivno označenega odmerka.
English: The mean duration of therapy was 29 days for posaconazole and 25 days for fluconazole/itraconazole.
Slovenian: Zdravljenje s posakonazolom je trajalo povprečno 29 dni in s flukonazolom/itrakonazolom 25 dni.
English: Non-Interchangeability between Noxafil Tablets and Noxafil Oral Suspension
Slovenian: Medsebojna nezamenljivost Noxafil tablet in Noxafil peroralne suspenzije
English: When administered through a peripheral venous catheter, the infusion should be administered over approximately 30 minutes (see section 4.8 and 6.6).
Slovenian: Če je zdravilo dano po perifernem venskem katetru, mora infundiranje trajati približno 30 minut (glejte poglavji 4.8 in 6.6).
English: Noxafil is a white, cherry flavoured, 105 mL oral suspension packaged in amber glass bottles.
Slovenian: Noxafil je bela 105 ml peroralna suspenzija z okusom češnje, pakirana v stekleničke iz rjavega stekla.
English: Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine since this may result in increased plasma concentrations of these medicinal products, leading to QTc prolongation and rare occurrences of torsades de pointes (see sections 4.4 and 4.5).
Slovenian: Sočasna uporaba s substrati CYP3A4 terfenadinom, astemizolom, cisapridom, pimozidom, halofantrinom ali kinidinom, ker lahko poveča plazemske koncentracije teh zdravil, kar pa lahko povzroči podaljšanje intervala QTc in redko tudi torsades de pointes (glejte poglavji 4.4 in 4.5).
English: See “Other medicines and Noxafil” below for information on other medicines which may interact with Noxafil.
Slovenian: Glejte "Druga zdravila in zdravilo Noxafil" (spodaj) za več informacij o drugih zdravilih, ki lahko medsebojno delujejo z zdravilom Noxafil.
English: • a blockage in your gut (intestinal obstruction) especially in the “ileum”.
Slovenian: • zapora črevesa (intestinalna obstrukcija), zlasti v delu, imenovanem "ileum".
English: Therefore, reserve azole antifungals, including posaconazole, for patients receiving a vinca alkaloid, including vincristine, who have no alternative antifungal treatment options.
Slovenian: Azolski antimikotiki, vključno s posakonazolom, naj bodo zato rezervirani za bolnike, ki prejemajo alkaloid vinke, vključno z vinkristinom, in ki nimajo alternativnih možnosti protiglivnega zdravljenja.
English: • severe sharp chest pain when breathing in (pleurritic pain)
Slovenian: • hude, ostre bolečine v prsih pri vdihu (plevritične bolečine)
English: • menstrual problems (abnormal vaginal bleeding)
Slovenian: • težave z menstruacijo (nenormalna krvavitev iz nožnice)
English: • shivering, feeling generally unwell
Slovenian: • drgetanje, splošno slabo počutje
English: Co-administration of posaconazole and ergot alkaloids is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba posakonazola in alkaloidov ergot je kontraindicirana (glejte poglavje 4.3).
English: If a central venous catheter was not readily available, patients could receive a single infusion over 30 minutes via a peripheral venous catheter.
Slovenian: Če centralni venski kateter ni bil na voljo, so bolniki lahko dobili enkratno 30-minutno infuzijo po perifernem venskem katetru.
English: Adverse reactions by body system and frequency reported in clinical trials and/or postmarketing use*
Slovenian: Neželeni učinki, razvrščeni po organskih sistemih in pogostnosti, o katerih so poročali v kliničnih preskušanjih in/ali v obdobju trženja*
English: No further increases in exposure were observed when doses above 800 mg daily were administered to patients and healthy volunteers.
Slovenian: Pri dajanju odmerkov nad 800 mg na dan bolnikom in zdravim prostovoljcem niso opažali nobenega nadaljnjega povečanja izpostavljenosti zdravilu.
English: 200 mg four times daily (hospitalized) then 400 mg twice daily
Slovenian: 200 mg štirikrat na dan (hospitalizirani), nato 400 mg dvakrat na dan
English: Posaconazole
Slovenian: Posakonazol
English: Co-administration of posaconazole with H2 receptor antagonists should be avoided if possible.
Slovenian: Sočasni uporabi posakonazola in antagonistov receptorjev H2 se je treba izogibati, če je le mogoče.
English: Following single-dose administration of posaconazole oral suspension, there was no effect of mild and moderate renal impairment (n=18, Cl cr ≥ 20 mL/min/1.73 m2) on posaconazole pharmacokinetics; therefore, no dose adjustment is required.
Slovenian: Po enkratnem odmerku peroralne suspenzije posakonazola blaga in zmerna okvara ledvic (n = 18, očistek kreatinina ≥ 20 ml/min/1,73 m2) nista vplivali na farmakokinetiko posakonazola, zato prilagoditev odmerka ni potrebna.
English: Duration of therapy should be based on the severity of the underlying disease, recovery from immunosuppression, and clinical response.
Slovenian: Trajanje zdravljenja je odvisno od resnosti bolnikove osnovne bolezni, okrevanja po imunosupresiji in bolnikovega kliničnega odziva.
English: • have a very slow heartbeat
Slovenian: • če imate zelo počasno bitje srca.