FrancophonIA/ELRC3.0 huggingface dataset:
English: Concomitant use of Atazanavir Krka /ritonavir and fluticasone or other glucocorticoids that are metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section 4.5).
Danish: Samtidig brug af Atazanavir Krka/ritonavir og fluticason eller andre glukokortikoider, som metaboliseres af CYP3A4, frarådes, medmindre de potentielle fordele ved behandlingen opvejer risikoen for systemiske bivirkninger forårsaget af kortikosteroider, herunder Cushings syndrom og binyrebarksuppression (se pkt.
English: - in patients without a functional CYP2C19 allele, close clinical and laboratory monitoring of voriconazole-associated adverse events is recommended.
Danish: - hos patienter uden en funktionel CYP2C19-allel anbefales tæt klinisk og laboratoriemæssig monitorering for voriconazol-relaterede bivirkninger.
English: When treating HIV infection, it is not always easy to identify what side effects are caused by Atazanavir
Danish: Ved behandling af hiv-infektion er det ikke altid let at sige, hvilke bivirkninger der skyldes Atazanavir Krka, anden medicin du tager eller selve hiv-infektionen.
English: Co-administration of Atazanavir Krka with these medicinal products is expected to substantially increase their concentrations and may result in PDE5associated adverse reactions such as hypotension, visual changes and priapism (see section 4.5).
Danish: Samtidig administration af Atazanavir Krka med disse lægemidler forventes at øge deres koncentration væsentligt og kan resultere i PDE5-relaterede bivirkninger såsom hypotension, synsforstyrrelser og priapisme (se pkt.
English: The mechanism of this decrease is unknown (see sections 4.2 and 4.4.
Danish: Mekanismen bag dette fald er ukendt (se pkt.
English: The body of the capsule is white or almost white colour, the cap of the capsule is dark brown colour.
Danish: Kapslens krop er hvid eller råhvid, kapslens hætte er mørkebrun.
English: CORTICOSTEROIDS Fluticasone propionate intranasal 50 µg 4 times daily for 7 days (ritonavir 100 mg capsules twice daily)
Danish: KORTIKOSTEROIDER Fluticasonpropionat intranasalt 50 µg 4 gange dagligt i 7 dage (ritonavir 100 mg kapsler 2 gange dagligt)
English: Capsule contents lactose monohydrate crospovidone (type A) magnesium stearate
Danish: Kapselindhold lactosemonohydrat crospovidon (type A) magnesiumstearat
English: It is important that you take Atazanavir Krka with food (a meal or a substantial snack) as this helps the body absorb the medicine.
Danish: Brug af Atazanavir Krka sammen med mad og drikke Det er vigtigt, at du tager Atazanavir Krka sammen med mad (et måltid eller et større mellemmåltid), da dette hjælper kroppen med at optage medicinen.
English: atazanavir AUC ↓ 35% atazanavir cmax ↓ 25% atazanavir cmin ↓ 49%
Danish: atazanavir Cmax ↓ 25% atazanavir Cmin ↓ 49%
English: Frequency de novo PI substitution (n=35)a,b M36, M46, I54, A71, V82 L10, I15, K20, V32, E35, S37, F53, I62, G73, I84, L90
Danish: Hyppighed de novo PI substitution (n=35)a,b M36, M46, I54, A71, V82 L10, I15, K20, V32, E35, S37, F53, I62, G73, I84, L90
English: 1157 cells/ mm3) and mean baseline plasma HIV-1 RNA was 4.09 log10 copies/ml (range: 3.28 to 5.00 log10 copies/ml).
Danish: 100-1.157 celler/mm3), og middel-baseline-plasma-hiv-1-RNA var 4,09 log10 kopier/ml (interval 3,28-5,00 log10 kopier/ml).
English: a The mean baseline CD4 cell count was 337 cells/mm3 (range: 14 to 1,543 cells/mm3) and the mean baseline plasma HIV-1
Danish: a Middel CD4-celletal ved baseline var 337 celler/mm3 (område: 14 til 1.543 celler/mm3) og middel plasma hiv-1
English: Each hard capsule contains 79.43 mg lactose monohydrate.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver hård kapsel indeholder 79,43 mg lactosemonohydrat.
English: Phenobarbital and phenytoin should be used with caution in combination with atazanavir /ritonavir.
Danish: Phenobarbital og phenytoin bør anvendes med forsigtighed sammen med atazanavir/ritonavir.
English: In HIV-infected patients (n=13), multiple dosing of atazanavir 400 mg (without ritonavir) once daily with food produced a geometric mean (CV%) for atazanavir cmax of 2298 (71) ng/ml, with time to cmax of approximately 2.0 hours.
Danish: Hos hiv-inficerede patienter (n=13) medførte gentagne doser af atazanavir 400 mg (uden ritonavir) én gang dagligt med føde en geometrisk gennemsnitlig (CV%) atazanavir-Cmax på 2.298 (71) ng/ml, med en tid til Cmax på ca. 2,0 timer.
English: If the co-administration of Atazanavir Krka with an NNRTI is required, an increase in the dose of both Atazanavir Krka and ritonavir to 400 mg and 200 mg, respectively, in combination with efavirenz could be considered with close clinical monitoring.
Danish: Ved behov for samtidig administration af Atazanavir Krka og en NNRTI, kan det overvejes at øge dosis af både Atazanavir Krka og ritonavir til henholdsvis 400 mg og 200 mg, i kombination med efavirenz, og under omhyggelig klinisk monitorering.
English: For treatmentexperienced paediatric patients, the mean baseline CD4 cell count was 522 cells/mm3 (range: 100 to
Danish: For de behandlingserfarne pædiatriske patienter var middel-baseline-CD4-celletal 522 celler/mm3 (interval
English: HDPE tablet container with child-resistant tamper evident PP with desiccant closure: 30 hard capsules and 90 (3 x 30) hard capsules, in a box.
Danish: HDPE-tabletbeholder med børnesikret og anbrudssikret PP-låg med tørremiddel: 30 hårde kapsler og 90 (3 x 30) hårde kapsler, i en æske.
English: c PI major L24I, D30N, V32I, L33F, M46IL, I47AV, G48V, I50LV, F53LY, I54ALMSTV, L76V, V82AFLST, I84V,
Danish: b Antal evaluerbare patienter c PI major L24I, D30N, V32I, L33F, M46IL, I47AV, G48V, I50LV, F53LY, I54ALMSTV, L76V, V82AFLST, I84V,
English: Rare (may affect up to 1 in 1,000 people): - gait disturbance (abnormal manner of walking) - oedema (swelling) - hepatosplenomegaly (enlargement of the liver and spleen) - myopathy (aching muscles, muscle tenderness of weakness, not caused by exercise) - kidney pain
Danish: Sjældne (kan forekomme hos op til 1 ud af 1.000 personer): - gangforstyrrelser - ødem (væskeophobninger) - forstørrelse af lever og milt - muskelsmerter og muskelømhed på grund af svaghed, der ikke er forårsaget af motion - nyresmerter
English: SEDATIVES Benzodiazepines Midazolam Triazolam
Danish: Midazolam Triazolam
English: 100 to <200 cells/mm
Danish: 100 til <200 celler/mm3
English: If genotyping is not feasible, full monitoring of safety and efficacy should be performed.
Danish: Hvis genotypebestemmelse ikke er mulig, skal der udføres
English: Therefore, Atazanavir Krka is contraindicated with medicinal products that are substrates of CYP3A4 and have a narrow therapeutic index: quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine, bepridil, triazolam, orally administered midazolam, and ergot alkaloids, particularly ergotamine and dihydroergotamine (see section 4.3).
Danish: Atazanavir Krka er derfor kontraindiceret med lægemidler, der er substrater af CYP3A4 og har et snævert terapeutisk indeks: quetiapin, lurasidon, alfuzosin, astemizol, terfenadin, cisaprid, pimozid, quinidin, bepridil, triazolam, oralt administreret midazolam og sekalealkaloider, især ergotamin og dihydroergotamin (se pkt.
English: Concomitant use of salmeterol and Atazanavir Krka may result in increased cardiovascular adverse events associated with salmeterol.
Danish: Samtidig brug af salmeterol og Atazanavir Krka kan resultere i en øget risiko for salmeterol-relaterede kardiovaskulære bivirkninger.
English: In clinical studies AI424-397 and AI424-451, paediatric patients 3 months to less than 11 years of age had a mean duration of treatment with atazanavir oral powder of 80 weeks.
Danish: Pædiatriske patienter fra 3 måneder til under 11 år havde i de kliniske studier AI424-397 og AI424-451 en gennemsnitlig behandlingsvarighed med atazanavir oralt pulver på 80 uger.
English: As a result, greater peak to trough ratios are observed; however at recommended doses, geometric mean atazanavir exposures (cmin, cmax and AUC) in paediatric patients are expected to be similar to those observed in adults.
Danish: Den geometriske middeleksponering for atazanavir (Cmin, Cmax og AUC) ved den anbefalede dosering forventes imidlertid at være den samme hos pædiatriske patienter, som er observeret hos voksne.
English: Metabolism and nutrition disorders uncommon: weight decreased, weight gain, anorexia, appetite increased
Danish: ikke almindelig: vægttab, vægtstigning, anoreksi, øget appetit
English: Cmax ng/mL Geometric mean (CV%) AUC ng•h/mL Geometric mean (CV%)
Danish: AUC ng•t/ml Geometrisk gennemsnit (CV%)
English: In a nonclinical fertility and early embryonic development study in rats, atazanavir altered oestrus cycling with no effects on mating or fertility (see section 5.3).
Danish: I et præklinisk studie af fertilitet og tidlig fosterudvikling hos rotter ændrede atazanavir brunstcyklus uden nogen effekt på parring eller fertilitet (se pkt.
English: Co-administration of Atazanavir Krka and medicinal products that induce CYP3A4 is not recommended (see sections 4.3 and 4.5).
Danish: Samtidig administration af Atazanavir Krka og lægemidler, der inducerer CYP3A4 frarådes (se pkt.
English: Atazanavir Krka should be discontinued if severe rash develops.
Danish: Atazanavir Krka bør seponeres, hvis der udvikles alvorligt udslæt.
English: Norbuprenorphine AUC ↑105% Norbuprenorphine cmax ↑61% Norbuprenorphine cmin ↑101%
Danish: Norbuprenorphin Cmax ↑61% Norbuprenorphin Cmin ↑101%
English: MARKETING AUTHORISATION NUMBER(S) EU/1/19/1353/002
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/19/1353/002
English: Hepatic transaminase elevations that occur with elevated bilirubin in patients receiving atazanavir should be evaluated for alternative aetiologies.
Danish: Patienter i behandling med atazanavir, som har forhøjede levertransaminaser og forhøjet bilirubin samtidig, bør evalueres for alternative ætiologier.
English: Six of 20 (30%) women on atazanavir /ritonavir 300/100 mg and 13 of 21 (62%) women on atazanavir /ritonavir 400/100 mg experienced grades 3 to 4 hyperbilirubinaemia.
Danish: 6 ud af 20 (30%) kvinder, der fik atazanavir/ritonavir 300/100 mg og 13 ud af 21 (62%) kvinder, der fik atazanavir/ritonavir 400/100 mg oplevede grad 3 til 4 hyperbilirubinæmi.
English: By as-treated analysis, excluding missing values, the proportions of patients with HIV RNA < 400 copies/ml (< 50 copies/ml) in the atazanavir + ritonavir arm and the lopinavir + ritonavir arm were 55% (40%) and 56% (46%), respectively.
Danish: Andelen af patienter med hiv-RNA <400 kopier/ml (<50 kopier/ml) i atazanavir + ritonavir-armen og lopinavir + ritonavir-armen var henholdsvis 55% (40%) og 56% (46%).
English: tenofovir disoproxil fumarate in treatment- experienced patients has been demonstrated in clinical study 045 and in treatment naive patients in clinical study 138 (see sections 4.8 and 5.1).
Danish: Der er vist effekt af atazanavir/ritonavir i kombination med tenofovirdisoproxilfumarat hos behandlingserfarne patienter i det kliniske studie 045 og hos behandlingsnaive patienter i det kliniske studie 138 (se pkt.
English: Your doctor should do blood tests prior you start Atazanavir Krka and during treatment.
Danish: Din læge bør tage blodprøver før og under behandling med Atazanavir Krka.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/19/1353/001
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/19/1353/001
English: For treatment-naive paediatric patients, the mean baseline CD4 cell count was 344 cells/mm3 (range: 2 to 800 cells/ mm3) and mean baseline plasma HIV-1 RNA was 4.67 log10 copies/ml (range: 3.70 to 5.00 log10 copies/ml).
Danish: For de behandlingsnaive pædiatriske patienter var middel-baseline-CD4-celletal 344 celler/mm3 (interval 2-800 celler/mm3), og middel-baseline-plasma-hiv-1-RNA var 4,67 log10 kopier/ml (interval 3,70-5,00 log10 kopier/ml).
English: Co-administration of Atazanavir Krka with other hormonal contraceptives or oral contraceptives containing progestogens other than norgestimate or norethindrone has not been studied, and therefore should be avoided (see section 4.5).
Danish: Samtidig administration af Atazanavir Krka og andre hormonelle kontraceptionsmidler eller orale kontraceptionsmidler indeholdende andre gestagener end norgestimat eller norethindron er ikke blevet undersøgt og bør derfor undgås (se pkt.
English: Interactions with other medicinal products The combination of Atazanavir Krka with atorvastatin is not recommended (see section 4.5).
Danish: Interaktioner med andre lægemidler Kombination af Atazanavir Krka og atorvastatin frarådes (se pkt.
English: In clinical trials of antiretroviral treatment naive patients treated with unboosted atazanavir, the I50L substitution, sometimes in combination with an A71V change, is the signature resistance substitution for atazanavir.
Danish: Voksne patienter, der ikke tidligere har været i antiretroviral behandling I kliniske studier med patienter, der ikke tidligere har modtaget antiretroviral behandling, og som behandles med ikke-boostet atazanavir, er I50L-substitutionen, nogle gange i kombination med A71V-ændring, den kendetegnende resistenssubstitution for atazanavir.
English: Atazanavir Krka 300 mg hard capsules are available in containers containing 30 hard capsules or 90 (3 x 30) hard capsules; in a box.
Danish: Atazanavir Krka 300 mg hårde kapsler fås i beholdere med 30 hårde kapsler eller 90 (3 x 30) hårde kapsler, i en æske.
English: The capsule cap is imprinted with black mark A150.
Danish: Kapslens hætte er påtrykt A150 med sort.
English: Norethindrone AUC ↑110%
Danish: Norbuprenorphin AUC ↑105%
English: In a clinical study AI424-020, paediatric patients 3 months to less than 18 years of age who received either the oral powder or capsule formulation had a mean duration of treatment with atazanavir of 115 weeks.
Danish: Pædiatriske patienter fra 3 måneder til under 18 år, som fik enten oralt pulver eller kapsler, havde i et klinisk studie AI424-020 en gennemsnitlig behandlingsvarighed med atazanavir på 115 uger.
English: - Gallbladder problems uncommonly happen in people taking atazanavir.
Danish: - Galdeblæreproblemer kan forekommme mindre hyppigt hos personer, der tager atazanavir.
English: HIV RNA <50 copies/ml, % All patientsd
Danish: hiv-RNA <50 kopier/ml, % Alle patienterd
English: Co-administration of atazanvir with voxilaprevircontaining regimens is not recommended.
Danish: Samtidig administration af atazanavir med regimer der indeholder voxilaprevir frarådes.
English: Lamotrigine should be used with caution in combination with atazanavir /ritonavir.
Danish: Lamotrigin bør anvendes med forsigtighed sammen med atazanavir/ritonavir.
English: administered with atazanavir.
Danish: Aktivt stof: atazanavir.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to combination antiretroviral therapy (CART).
Danish: Der er rapporteret tilfælde af osteonekrose hos patienter med fremskreden hiv-sygdom og/eller patienter i langvarig kombinationsbehandling med antiretrovirale lægemidler (CART).
English: Efficacy data observed in the 41 paediatric patients aged 6 years to less than 18 years that received atazanavir capsules with ritonavir are presented in Table 7.
Danish: I tabel 7 ses data for virkningen hos de 41 pædiatriske patienter i alderen fra 6 år til under 18 år, som fik atazanavir kapsler med ritonavir.
English: Atazanavir Krka Dose once daily (mg)
Danish: Atazanavir Krka en daglig dosis (mg)
English: shellac black ferric oxide (E172) potassium hydroxide
Danish: shellac sort jernoxid (E172) kaliumhydroxid
English: The body of the capsule is white or almost white colour, the cap of the capsule is brownish-orange colour.
Danish: Kapslens krop er hvid eller råhvid, kapslens hætte er brun-orange.
English: Atazanavir and fluconazole concentrations were not significantly modified when atazanavir /ritonavir was coadministered with fluconazole.
Danish: Atazanavir- og fluconazolkoncentrationerne ændredes ikke signifikant ved samtidig administration af atazanavir/ritonavir og fluconazol.
English: weeks for PIs, 281 weeks for NRTIs, and 85 weeks for NNRTIs.
Danish: For randomiserede patienter var middeltiden for tidligere antiretroviral eksponering 138 uger for PIer, 281 uger for NRTIer og 85 uger for NNRTIer.
English: The mechanism of interaction is CYP3A4 and UGT1A1 inhibition.
Danish: Interaktionsmekanismen er CYP3A4- og UGT1A1-hæmning.
English: Co-administration of voriconazole and Atazanavir Krka with ritonavir is not recommended, unless an assessment of the benefit/risk justifies the use of voriconazole.
Danish: Samtidig administration af voriconazol og Atazanavir Krka med ritonavir frarådes, medmindre det vurderes, at fordel/risiko-forholdet berettiger brugen af voriconazol.
English: The mechanism of interaction is decreased solubility of atazanavir as intra-gastric pH increases with H2- blockers.
Danish: Interaktionsmekanismen er nedsat opløselighed af atazanavir pga. intragastrisk pH-stigning med H2-blokkere.
English: These are listed under Do not take Atazanavir Krka, at the start of Section 2.
Danish: Disse lægemidler er nævnt i starten af punkt 2 under Tag ikke Atazanavir Krka.
English: HERBAL PRODUCTS St. John's wort (Hypericum perforatum)
Danish: NATURLÆGEMIDDEL Perikon (Hypericum perforatum)
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING CONTAINER LABEL
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN INDRE EMBALLAGE BEHOLDERETIKET
English: Atazanavir Krka with ritonavir should be used with caution in patients with mild hepatic impairment.
Danish: Atazanavir Krka med ritonavir bør anvendes med forsigtighed til patienter med let nedsat leverfunktion.
English: Co-administration of simvastatin or lovastatin with atazanavir is contraindicated due to an increased risk of myopathy including rhabdomyolysis (see section 4.3).
Danish: simvastatin eller lovastatin og atazanavir er kontraindiceret på grund af øget risiko for myopati, inklusive rabdomyolyse (se pkt.
English: Calcium channel blockers Bepridil
Danish: Calciumantagonister Bepridil
English: 25-O-desacetyl-rifabutin AUC 25-O-desacetyl-rifabutin cmax 25-O-desacetyl-rifabutin cmin
Danish: 25-O-desacetyl-rifabutin Cmax ↑677% 25-O-desacetyl-rifabutin Cmin ↑1045%
English: Coadministration with atazanavir may result in increased concentrations of the PDE5 inhibitor and an increase in PDE5-associated adverse events, including hypotension, visual changes, and priapism.
Danish: Samtidig administration af atazanavir kan medføre øget koncentration af PDE5-hæmmeren og øget risiko for PDE5-relaterede bivirkninger, inklusive hypotension, synsforstyrrelser og priapisme.
English: Due to CYP3A4 inhibition by atazanavir, concentrations of quetiapine are expected to increase.
Danish: Da atazanavir hæmmer CYP3A4, forventes koncentrationen af quetiapin at stige.
English: Co-administration with atazanavir may result in increased concentrations of the PDE5 inhibitor and an increase in PDE5inhibitor-associated adverse events.
Danish: Administration sammen med atazanavir kan medføre øget koncentration af PDE5-hæmmeren og øget risiko for PDE5-hæmmerrelaterede bivirkninger.
English: Co-administration of atazanavir/ritonavir and these glucocorticoids is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4).
Danish: Samtidig administration af atazanavir/ritonavir og disse glukokortikoider frarådes, medmindre den potentielle fordel ved behandlingen opvejer risikoen for systemiske bivirkninger (se pkt.
English: What you need to know before you take Atazanavir Krka
Danish: Det skal du vide, før du begynder at tage Atazanavir Krka
English: * When compared to atazanavir 300 mg and ritonavir 100 mg without nevirapine.
Danish: * Sammenlignet med atazanavir 300 mg og ritonavir 100 mg uden nevirapin.
English: * When compared to atazanavir 300 mg/ritonavir 100 mg once daily in the evening without efavirenz.
Danish: * Sammenlignet med atazanavir 300 mg/ritonavir 100 mg én gang dagligt om aftenen uden efavirenz.
English: Co-administration of Atazanavir Krka with nevirapine or efavirenz is not recommended (see section 4.5).
Danish: Samtidig administration af Atazanavir Krka og nevirapin eller efavirenz frarådes (se pkt.
English: Integrase Inhibitors Raltegravir 400 mg twice daily (atazanavir/ritonavir)
Danish: Integrasehæmmere Raltegravir 400 mg 2 gange dagligt (atazanavir/ritonavir)
English: Uncommon (may affect up to 1 in 100 people): - peripheral neuropathy (numbness, weakness, tingling or pain in the arms and legs) - hypersensitivity (allergic reaction) - asthenia (unusual tiredness or weakness) - weight decreased, weight gain, anorexia (loss of appetite), appetite increased - depression, anxiety, sleep disorder - disorientation, amnesia (loss of memory), dizziness, somnolence (sleepiness), abnormal dream - syncope (fainting), hypertension (high blood pressure) - dyspnoea (shortness of breath) - pancreatitis (inflammation of the pancreas), gastritis (inflammation of the stomach), stomatitis,
Danish: Ikke almindelige (kan forekomme hos op til 1 ud af 100 personer): - følelsesløshed, svaghed, prikken eller smerte i arme og ben (perifer neuropati) - overfølsomhed (allergisk reaktion) - usædvanlig træthed eller svaghed - vægttab, vægtøgning, manglende appetit, øget appetit - depression, angst, søvnforstyrrelser - desorientering, hukommelsestab, svimmelhed, søvnighed, abnorme drømme - besvimelse, højt blodtryk - vejrtrækningsbesvær (dyspnø) - betændelse i bugspytkirtlen, irritation af slimhinden i mavesækken, sår i munden og forkølelsessår, smagsforstyrrelse, luft i maven, tør mund, udspilet mave - angioødem (voldsom hævelse af hud og andre steder, som oftest læber og øjne) - hårtab, kløe - svind af muskelmasse, ledsmerter, muskelsmerter - nyrebetændelse (interstitiel nefritis), blod i urinen (hæmaturi), for meget protein i urinen, hyppig vandladning - brystforstørrelse hos mænd - brystsmerter, utilpashed, feber - søvnløshed
English: Total rifabutin and 25-O-desacetylrifabutin AUC ↑119% (↑78%
Danish: 25-O-desacetyl-rifabutin AUC ↑119%
English: In case of withdrawal of ritonavir from the recommended atazanavir boosted regimen (see section 4.4) The same recommendations for drug drug interactions would apply except: that co-administration is not recommended with tenofovir, boceprevir, carbamazepine, phenytoin, phenobarbital, proton pump inhibitors, and buprenorphine.
Danish: 4.4) De samme anbefalinger for lægemiddelinteraktioner gælder med undtagelse af: - at administration sammen med tenofovir, boceprevir, carbamazepin, phenytoin, phenobarbital, protonpumpehæmmere og buprenorphin frarådes.
English: ritonavir AUC ↓ 36% ritonavir cmax ↓ 27% ritonavir cmin ↓ 45%
Danish: ritonavir Cmax ↓ 27% ritonavir Cmin ↓ 45%
English: Lopinavir/ritonavirc (400 mg/100 mg twice daily) n=443
Danish: lopinavir/ritonavirc (400 mg/100 mg 2 gange dagligt) n=443
English: Each hard capsule contains 158.86 mg lactose monohydrate.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver hård kapsel indeholder 158,86 mg lactosemonohydrat.
English: The recommended dose of Atazanavir Krka capsules is 300 mg once daily taken with ritonavir 100 mg once daily and with food.
Danish: Den anbefalede dosis Atazanavir Krka kapsler er 300 mg én gang dagligt sammen med 100 mg ritonavir én gang dagligt og i forbindelse med et måltid.
English: Each hard capsule contains 105.91 mg lactose monohydrate.
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver hård kapsel indeholder 105,91 mg lactosemonohydrat.
English: This decrease in atazanavir cmin, might negatively impact the efficacy of atazanavir.
Danish: Dette fald i atazanavir Cmin kan påvirke effekten af atazanavir negativt.