FrancophonIA/ELRC3.0 huggingface dataset:
English: Serious side effects with Strimvelis may include effects linked to autoimmunity (when the immune system attacks the body's own cells) such as haemolytic anaemia (low red blood cell counts due to their too rapid breakdown), aplastic anaemia (low blood cell counts due to damaged bone marrow), hepatitis (liver inflammation), thrombocytopenia (low blood platelet count) and Guillain-Barré syndrome (damage to nerves that can result in pain, numbness, muscle weakness and difficulty walking).
Slovenian: Resni neželeni učinki zdravila Strimvelis so lahko povezani z avtoimunskimi motnjami (ko imunski sistem napade celice lastnega telesa), kot so hemolitična anemija (nizka raven rdečih krvnih celic zaradi njihove prehitre razgradnje), aplastična anemija (nizka raven krvnih celic zaradi okvare kostnega mozga), hepatitis (vnetje jeter), trombocitopenija (nizka raven trombocitov) in Guillain-Barréjev sindrom (poškodba živcev, ki lahko povzroči bolečino, odrevenelost, mišično oslabelost in težave pri hoji).
English: Because Strimvelis is produced using a retrovirus, there could be a potential risk of cancer caused by unintended changes in the genetic material, although no such cases have been seen so far.
Slovenian: Ker se zdravilo Strimvelis izdela z uporabo retrovirusa, obstaja potencialno tveganje za raka zaradi nenačrtovanih sprememb genskega materiala, čeprav do zdaj niso opazili takih primerov.
English: In addition, the company that makes Strimvelis will provide educational materials for patients and healthcare professionals with information on the medicine, and patients will have to sign a consent form before treatment is started.
Slovenian: Poleg tega bo družba, ki izdeluje zdravilo Strimvelis, priskrbela izobraževalna gradiva za bolnike in zdravstvene delavce z informacijami o zdravilu, bolniki pa bodo morali pred začetkom zdravljenja podpisati obrazec o soglasju.
English: It must not be used in patients who have tested positive for human immunodeficiency virus (HIV, the virus that causes AIDS) or some other infections, or in patients who have previously had gene therapy treatment.
Slovenian: Ne sme se uporabljati pri bolnikih, ki imajo pozitiven izvid testiranja za okužbo z virusom humane imunske pomanjkljivosti (virusom HIV, ki povzroča aids) ali kakšno drugo okužbo, in bolnikih, ki so v preteklosti že bili zdravljeni z genskim zdravljenjem.
English: What benefits of Strimvelis have been shown in studies?
Slovenian: Kakšne koristi je zdravilo Strimvelis izkazalo v študijah?
English: However, measures are in place to monitor such events once the medicine is in use by using a registry of patients to study their long-term progress.
Slovenian: Vzpostavljeni so ukrepi za spremljanje takih dogodkov po uporabi zdravila, in sicer z vključitvijo bolnikov v register za proučevanje njihovega dolgoročnega napredka.
English: What are the risks associated with Strimvelis?
Slovenian: Kakšna tveganja so povezana z zdravilom Strimvelis?
English: Because the number of patients with ADA-SCID is low, the disease is considered ‘rare', and Strimvelis was designated an ‘orphan medicine' (a medicine used in rare diseases) on 26 August 2005.
Slovenian: Ker je bolnikov z ADA-SCID malo, velja ta bolezen za redko, zato je bilo zdravilo Strimvelis 26. avgusta 2005 določeno kot „zdravilo sirota“ (zdravilo za zdravljenje redkih bolezni).
English: Why is Strimvelis approved?
Slovenian: Zakaj je bilo zdravilo Strimvelis odobreno?
English: Because ADA is essential for maintaining healthy lymphocytes (white blood cells that fight off infections), the immune system of patients with ADA-SCID does not work properly and without effective treatment they rarely survive more than 2 years.
Slovenian: Ker je ADA ključen za ohranjanje zdravih limfocitov (belih krvnih celic, ki premagujejo okužbe), imunski sistem bolnikov z ADA-SCID ne deluje pravilno in bolniki brez učinkovitega zdravljenja redko preživijo dlje kot dve leti.
English: The benefits of Strimvelis have been shown in one main study involving 12 patients from 6 months to around 6 years old with ADA-SCID.
Slovenian: Koristi zdravila Strimvelis so se izkazale v eni glavni študiji z 12 bolniki z ADA-SCID, starimi od 6 mesecev do približno 6 let.
English: Strimvelis is given as an infusion (drip) into a vein over about 20 minutes.
Slovenian: Zdravilo Strimvelis se daje v infuziji (kapalni) v veno, ki traja približno 20 minut.
English: For more information about treatment with Strimvelis, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Slovenian: Za več informacij o zdravljenju z zdravilom Strimvelis preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
English: The full EPAR for Strimvelis can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Strimvelis je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: To prepare Strimvelis, two samples of the patient's bone marrow are collected, one to make Strimvelis and one that is kept as a back-up in case Strimvelis cannot be given or does not work.
Slovenian: Za pripravo zdravila Strimvelis se odvzameta dva vzorca bolnikovega kostnega mozga, eden za izdelavo zdravila Strimvelis in drugi kot rezervni vzorec v primeru, če zdravila Strimvelis ni mogoče dati ali če ne deluje.
English: This type of medicine works by delivering genes into the body.
Slovenian: Gre za skupino zdravil, ki delujejo tako, da prenesejo gene v telo.
English: For the full list of restrictions and side effects reported with Strimvelis, see the package leaflet.
Slovenian: Za celoten seznam omejitev in neželenih učinkov, o katerih so poročali pri uporabi zdravila Strimvelis, glejte navodilo za uporabo.
English: Results from the main study show that Strimvelis is effective at improving survival of ADA-SCID patients.
Slovenian: Rezultati glavne študije kažejo, da je zdravilo Strimvelis učinkovito pri izboljševanju preživetja pri bolnikih z ADA-SCID.
English: Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Strimvelis, including the appropriate precautions to be followed by healthcare professionals and patients.
Slovenian: V skladu s tem načrtom so bile v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo vključene informacije o varnosti, vključno s previdnostnimi ukrepi, ki jih morajo upoštevati zdravstveni delavci in bolniki.
English: The dose depends on the bodyweight of the patient.
Slovenian: Odmerek je odvisen od telesne mase bolnika.
English: Strimvelis contains cells derived from the patient's own bone marrow.
Slovenian: Zdravilo Strimvelis vsebuje celice, pridobljene iz bolnikovega lastnega kostnega mozga.
English: For practical information about using Strimvelis, patients should read the package leaflet or contact their doctor or pharmacist.
Slovenian: Za praktične informacije o uporabi zdravila Strimvelis naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
English: Strimvelis is a type of advanced therapy medicine called a ‘gene therapy product'.
Slovenian: Zdravilo Strimvelis spada v skupino zdravil za napredno zdravljenje, ki se imenujejo „zdravila za gensko zdravljenje“.
English: Strimvelis can only be used to treat the same patient whose bone marrow was used to make the medicine.
Slovenian: Zdravilo Strimvelis se uporablja le za zdravljenje bolnika, čigar kostni mozeg je bil uporabljen za izdelavo zdravila.
English: Strimvelis provides the opportunity of a cure that improves the working of the immune system for patients with ADA-SCID, which is a life-threatening condition.
Slovenian: Zdravilo Strimvelis omogoča možnost zdravljenja, ki izboljšuje delovanje imunskega sistema pri bolnikih z ADA-SCID, ki je življenjsko nevarna bolezen.
English: A working gene for ADA is inserted into the CD34+ cells using a type of virus called a retrovirus, which has been altered genetically so that it can carry the ADA gene into cells and does not cause viral disease in humans.
Slovenian: Gen, ki izdeluje ADA, se vstavi v celice CD34+ z uporabo vrste virusa, imenovanega retrovirus, ki je bil genetsko spremenjen, da lahko prenaša gen ADA v celice in ne povzroči virusnih bolezni pri ljudeh.
English: Some of the cells (called CD34+ cells) have been genetically modified to contain a working gene for ADA.
Slovenian: Nekatere celice (imenovane celice CD34+) so bile gensko spremenjene, da vsebujejo gen, ki izdeluje ADA.
English: Strimvelis is a medicine used to treat severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID).
Slovenian: Zdravilo Strimvelis se uporablja za zdravljenje hude kombinirane imunske pomanjkljivosti zaradi pomanjkanja adenozin deaminaze (ADA-SCID).
English: ADA-SCID is a rare inherited condition in which there is a change (mutation) in the gene needed to make an enzyme called adenosine deaminase (ADA).
Slovenian: ADA-SCID je redka prirojena motnja, pri kateri gre za spremembo (mutacijo) gena, potrebnega za izdelovanje encima, imenovanega adenozin deaminaza (ADA).
English: Autologous CD34+ enriched cell fraction that contains CD34+ cells transduced with retroviral vector that encodes for the human ADA cDNA sequence
Slovenian: Strimvelis avtologna, s CD34+ obogatena celična frakcija s celicami CD34+, transduciranimi z retrovirusnim vektorjem, ki kodira zaporedje človeške adenozin deaminaze (ADA) cDNA
English: Strimvelis is used in patients with ADA-SCID who cannot be treated by a bone-marrow transplant because they do not have a suitable, matched, related donor.
Slovenian: Zdravilo Strimvelis se uporablja pri bolnikih z ADA-SCID, ki niso primerni za presaditev kostnega mozga, ker nimajo primernega, usklajenega, sorodnega dajalca.
English: Strimvelis can only be obtained with a prescription and treatment should only be given in a specialist transplant centre by a doctor who has experience in the treatment of ADA-SCID and the use of this type of medicine.
Slovenian: Izdaja zdravila Strimvelis je le na recept in dati ga sme le zdravnik, ki ima izkušnje z zdravljenjem bolnikov z ADA-SCID in uporabo tovrstnih zdravil.
English: Before Strimvelis is given, patients receive conditioning (preparatory) treatment with another medicine, busulfan, to get rid of their abnormal bone marrow cells.
Slovenian: Preden se uporabi zdravilo Strimvelis, bo bolnik prejel predpripravo pred zdravljenjem z drugim zdravilom, busulfanom, da se odstranijo nenormalne celice kostnega mozga.
English: How is Strimvelis used?
Slovenian: Kako se zdravilo Strimvelis uporablja?
English: Strimvelis must not be used in patients who have leukaemia (cancer of white blood cells) or myelodysplasia (a type of bone marrow disorder) or have had these conditions in the past.
Slovenian: Zdravila Strimvelis ne smejo dobiti bolniki, ki imajo ali so v preteklosti imeli levkemijo (rak belih krvnih celic) ali mielodisplazijo (vrsto bolezni kostnega mozga).
English: To make Strimvelis, a sample of the patient's bone marrow is collected.
Slovenian: Za izdelavo zdravila Strimvelis se odvzame vzorec bolnikovega kostnega mozga.
English: Once given back to the patient into a vein, Strimvelis is transported in the bloodstream to the bone marrow where the CD34+ cells start to grow and make normal lymphocytes that can produce ADA.
Slovenian: Po dajanju zdravila Strimvelis v veno se zdravilo prenese po krvnem obtoku do kostnega mozga, kjer celice CD34+ začnejo rasti in izdelovati normalne limfocite, ki proizvajajo ADA. Ti limfociti izboljšajo bolnikovo zmožnost bojevanja proti okužbam in tako premagajo simptome bolezenskih stanj, ki so povezana z imunskim sistemom.
English: Then, CD34+ cells (cells that can make lymphocytes) are extracted from the bone marrow cells.
Slovenian: Nato se iz celic kostnega mozga pridobijo celice CD34+ (celice, ki izdelujejo limfocite).
English: How does Strimvelis work?
Slovenian: Kako zdravilo Strimvelis deluje?
English: Min, Max ND: Not determined
Slovenian: Min, Max ND: ni bilo določeno
English: Do not take a double dose (two doses close together).
Slovenian: Ne vzemite dvojnega odmerka (dveh odmerkov skupaj).
English: None of these effects have been observed in humans.
Slovenian: Nobenega od teh učinkov niso opazili pri človeku.
English: Category/ Substitution, n (%)
Slovenian: Kategorija/substitucija, n (%)
English: Ribavirin can harm your unborn baby.
Slovenian: Ribavirin lahko škoduje nerojenemu otroku.
English: Loc. Fontana del Ceraso 03012 Anagni (FR) Italy
Slovenian: Loc. Fontana del Ceraso 03012 Anagni (FR) Italija
English: End of treatment
Slovenian: Konec zdravljenja
English: Black/African American Other
Slovenian: Črnci/Afroameričani
English: The studies presented in Table 4 were conducted in healthy adult subjects unless otherwise noted.
Slovenian: Študije, predstavljene v tabeli 4, so bile izvedene pri zdravih odraslih osebah, če ni navedeno drugače.
English: *Compared to historical data.
Slovenian: * V primerjavi s preteklimi podatki.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 August 2014
Slovenian: Datum prve odobritve: 22. avgust 2014
English: Excretion into milk
Slovenian: Izločanje v mleko
English: The absolute bioavailability of the tablet formulation is 67%.
Slovenian: Absolutna biološka uporabnost zdravila v obliki tablete je 67 %.
English: Not reported CP classes
Slovenian: Ni podatka CP razredi
English: Patient population*
Slovenian: Populacija bolnikov*
English: Relapse includes observations through follow-up Week 24.
Slovenian: Ponovitev vključuje opazovanja med spremljanjem do 24. tedna.
English: and very rare (<1/10,000).
Slovenian: < 1/1.000) in zelo redki (< 1/10.000).
English: HORMONAL CONTRACEPTIVES
Slovenian: HORMONSKI KONTRACEPTIVI
English: Interaction not studied.
Slovenian: Interakcij niso proučevali.
English: Ribavirin may be added based on clinical assessment of an individual patient.
Slovenian: Ribavirin se lahko doda na osnovi klinične presoje pri vsakem bolniku posebej.
English: Treatment of overdose with daclatasvir should consist of general supportive measures, including monitoring of vital signs, and observation of the patient's clinical status.
Slovenian: Zdravljenje prevelikega odmerjanja daklatasvirja mora obsegati splošne podporne ukrepe, vključno s spremljanjem vitalnih znakov in opazovanjem kliničnega stanja bolnika.
English: The relevance of including ribavirin as part of the 24-week regimen is unclear.
Slovenian: Pomen vključitve ribavirina v 24-tedenski režim zdravljenja ni jasen.
English: Demographic and baseline characteristics of these 50 patients were generally comparable to those for patients who received 12 weeks of study treatment.
Slovenian: Demografske in izhodiščne lastnosti teh 50 bolnikov so bile na splošno primerljive s tistimi pri bolnikih, ki so se v študiji zdravili 12 tednov.
English: * the effect of 60 mg daclatasvir on lopinavir may be higher.
Slovenian: * učinek 60 mg daklatasvirja na lopinavir je lahko večji.
English: Patients who are identified as being at high risk of bradyarrhythmia should be continuously monitored for 48 hours in an appropriate clinical setting.
Slovenian: Bolnike, pri katerih se ugotovi veliko tveganje za bradiaritmijo, je treba 48 ur neprekinjeno spremljati v ustrezni klinični ustanovi.
English: This lowers the amount of hepatitis C virus in your body and removes the virus from your blood over a period of time.
Slovenian: Na ta način zmanjša količino virusa hepatitisa C v telesu in sčasoma virus odstrani iz krvi.
English: Carcinogenesis and mutagenesis
Slovenian: Karcinogeneza in mutageneza
English: The HCV RNA thresholds that trigger discontinuation of treatment (i.e. treatment stopping rules) are presented in Table 3.
Slovenian: Mejne vrednosti HCV RNA, ki so razlog za ukinitev zdravljenja (pravila za ukinitev zdravljenja), so predstavljena v tabeli 3.
English: Belgique/België/Belgien
Slovenian: Belgique/België/Belgien N.V.
English: The relevance of adding ribavirin to that regimen is unclear (see section 5.1).
Slovenian: Pomen dodatka ribavirina k temu režimu zdravljenja ni jasen (glejte poglavje 5.1).
English: Resistance in clinical studies
Slovenian: Odpornost v kliničnih študijah
English: Caution is advised.
Slovenian: Priporočamo previdnost.
English: Study AI444010
Slovenian: Študija AI444010
English: If you are taking any of these medicines, your doctor may decide to change your daily dose of Daklinza to ensure that the treatment is safe and effective for you.
Slovenian: Če jemljete katero koli od teh zdravil, lahko zdravnik spremeni dnevni odmerek zdravila Daklinza, da zagotovi, da bo zdravljenje varno in učinkovito.
English: If you take any of these medicines, tell your doctor immediately.
Slovenian: Če jemljete katero koli od teh zdravil, o tem nemudoma obvestite svojega zdravnika.
English: Do not use this medicine after the expiry date which is stated on the carton and blister after "EXP".
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu poleg oznake “EXP”.
English: **GS-331007 is the major circulating metabolite of the prodrug sofosbuvir.
Slovenian: **GS-331007 je glavni presnovek predzdravila sofosbuvirja v obtoku.
English: NARCOTIC ANALGESICS
Slovenian: NARKOTIČNI ANALGETIKI
English: Concerning genotype-specific virological and clinical activity, see section 5.1.
Slovenian: Za genotipsko specifično virološko in klinično aktivnost glejte poglavje 5.1.
English: Patients should be instructed to swallow the tablet whole.
Slovenian: Bolniku je treba pojasniti, da mora tableto pogoltniti celo.
English: Long term efficacy data
Slovenian: Podatki o dolgoročni učinkovitosti
English: Blood and lymphatic system disorders very common anaemia
Slovenian: Bolezni krvi in limfatičnega sistema zelo pogosti anemija
English: Study AI444042
Slovenian: Študija AI444042
English: In vitro studies indicate that daclatasvir is actively and passively transported into hepatocytes.
Slovenian: In vitro študije kažejo, da daklatasvir aktivno in pasivno prehaja v hepatocite.
English: Outcomes by prior treatment experience are presented in Table 11.
Slovenian: Izidi glede na predhodno zdravljenje so predstavljeni v tabeli 11.
English: The duration of your treatment with Daklinza will be either 12 or 24 weeks.
Slovenian: Zdravljenje z zdravilom Daklinza lahko traja 12 ali 24 tednov.
English: The mean score on the FibroTest (a validated non-invasive diagnostic assay) was 0.460 (range: 0.03 to 0.89).
Slovenian: Povprečna ocena FibroTesta (validirani neinvazivni diagnostični test) je znašala 0,460 (razpon: od 0,03 do 0,89).
English: The most frequently detected NS5A RAVs included Q30E or Q30R in combination with L31M.
Slovenian: Najpogosteje odkrite RAV NS5A so vključevale Q30E ali Q30R v kombinaciji z L31M.
English: Clinically relevant increase in concentration is indicated as “↑”, clinically relevant decrease as “↓”, no clinically relevant change as “↔”.
Slovenian: Klinično pomembno povečanje koncentracije je prikazano kot “↑”, klinično pomembno zmanjšanje kot “↓”, brez klinično pomembne spremembe pa kot “↔”.
English: Grade 3 adverse reactions were reported in less than 1% of patients, and no patients had a Grade 4 adverse reaction.
Slovenian: O neželenih učinkih stopnje 3 so poročali pri manj kot 1 % bolnikov, o neželenih učinkih stopnje 4 pa niso poročali pri nobenem bolniku.
English: No dose adjustment of Daklinza or buprenorphine may be required, but it is recommended that patients should be monitored for signs of opiate toxicity.
Slovenian: Odmerka zdravila Daklinza ali buprenorfina morda ni potrebno prilagajati, vendar je priporočljivo, da se bolnike spremlja na znake opiatne toksičnosti.
English: It is very important that you also read the package leaflets for the other medicines that you will be taking with Daklinza.
Slovenian: Zelo pomembno je, da preberete tudi navodila za uporabo drugih zdravil, ki jih boste uporabljali skupaj z zdravilom Daklinza.
English: *results are dose-normalised to 60 mg dose.
Slovenian: *Rezultati so normirani na 60-mg odmerek.
English: If the starting dose is not well-tolerated, the dose should be reduced as clinically indicated, based on haemoglobin and creatinine clearance measurements (see Table 2).
Slovenian: Če bolnik začetnega odmerka ne prenaša dobro, je treba odmerek zmanjšati kot je to klinično indicirano na osnovi laboratorijskih vrednosti hemoglobina in kreatininskega očistka (glejte tabelo 2).
English: The active transport is mediated by OCT1 and other unidentified uptake transporters.
Slovenian: Aktivni transport poteka s pomočjo OCT1 in z drugimi neznanimi prenašalci privzema.
English: Effect of food on oral absorption
Slovenian: Vpliv hrane na absorpcijo pri peroralni uporabi
English: If available, ratios of geometric means are shown, with 90% confidence intervals (CI) in parentheses.
Slovenian: Če so podatki na voljo, so v oklepaju prikazana razmerja geometrijskih sredin z 90-% intervali zaupanja (IZ).
English: Keep the tablet blister with you so that you can easily describe what you have taken.
Slovenian: S seboj vzemite ovojnino zdravila, da boste zdravstvenemu osebju lažje pojasnili, kaj ste vzeli.
English: Mainly interferon-based therapy +/-NS3/4 PI.
Slovenian: Večinoma z režimom na osnovi interferona +/-NS3/4 PI.
English: Age (years): median (range) Race:
Slovenian: Starost (leta): mediana (razpon) Rasa:
English: Genotype 1a Genotype 1b Genotype 2 Genotype 3 N=301
Slovenian: Genotip 1a Genotip 1b Genotip 2 Genotip 3 N=301
English: If you are pregnant you must not take Daklinza.
Slovenian: Če ste noseči, zdravila Daklinza ne smete jemati.
English: Uxbridge UB8 1DH United Kingdom
Slovenian: Uxbridge UB8 1DH Velika Britanija
English: If you have any of these side effects, do not drive or use any tools or machines.
Slovenian: primeru pojava takšnih neželenih učinkov ne smete voziti vozil ali upravljati z orodji ali s stroji.
English: This leaflet was last revised in <{MM/YYYY}>.
Slovenian: Navodilo je bilo nazadnje revidirano dne <{MM/LLLL}>.
English: Pharmacotherapeutic group: Direct-acting antiviral, ATC code: J05AX14
Slovenian: Farmakoterapevtska skupina: Zdravila z direktnim delovanjem na viruse, oznaka ATC: J05AX14
English: Other medicines and Daklinza
Slovenian: Druga zdravila in zdravilo Daklinza
English: Daclatasvir in vitro did not inhibit (IC50 >40 µM) CYP enzymes 1A2, 2B6, 2C8, 2C9, 2C19, or 2D6.
Slovenian: Daklatasvir in vitro ni zaviral (IC50 > 40 µM) encimov CYP 1A2, 2B6, 2C8, 2C9, 2C19 ali 2D6.
English: Study conducted in patients with chronic HCV infection
Slovenian: Študija, izvedena pri bolnikih s kronično okužbo s HCV
English: Treatment with Daklinza should be initiated and monitored by a physician experienced in the management of chronic hepatitis C.
Slovenian: Zdravljenje z zdravilom Daklinza mora uvesti in spremljati zdravnik, ki ima izkušnje z zdravljenjem kroničnega hepatitisa C.
English: All 4 patients achieved SVR12.
Slovenian: SVR12 je bil dosežen pri vseh 4 bolnikih.
English: In vitro and in vivo studies showed that daclatasvir is a substrate of P-gp.
Slovenian: In vitro ter in vivo študije so pokazale, da je daklatasvir substrat za P-gp.
English: Because daclatasvir is highly protein bound (99%) and has a molecular weight >500, dialysis is unlikely to significantly reduce plasma concentrations of daclatasvir.
Slovenian: Ker se daklatasvir močno veže na beljakovine (99 %), njegova molekulska masa pa je > 500, je malo verjetno, da bi dializa pomembneje zmanjšala koncentracije daklatasvirja v plazmi.
English: Resistance in cell culture
Slovenian: Odpornost v celični kulturi
English: >30 to ≤50 mL/min
Slovenian: > 30 do ≤ 50 ml/min
English: There are no data from the use of daclatasvir in pregnant women.
Slovenian: Podatkov o uporabi daklatasvirja pri nosečnicah ni.
English: Not all packages may be marketed in your country.
Slovenian: Na trgu morda ni vseh navedenih pakiranj.
English: Emerging resistance
Slovenian: Pojav odpornosti
English: CCR5 receptor antagonist Maraviroc
Slovenian: Antagonist receptorjev CCR5 Maravirok