FrancophonIA/ELRC3.0 huggingface dataset:
English: Pharmacotherapeutic group: angiotensin II antagonists and diuretics, ATC code: C09DA04.
Croatian: Farmakoterapijska skupina: antagonisti angiotenzina II i diuretici, ATK oznaka: C09DA04.
English: Side effects reported in clinical studies for patients treated with Ifirmacombi were:
Croatian: Nuspojave prijavljene u kliničkim ispitivanjima u bolesnika liječenih lijekom Ifirmacombi bile su:
English: Additional information on hydrochlorothiazide interactions: When administered concurrently, the following medicinal products may interact with thiazide diuretics:
Croatian: Dodatne informacije o interakcijama hidroklorotiazida: Pri istodobnom liječenju, sljedeći lijekovi mogu ući u interakciju s tiazidskim diureticima:
English: If you forget to take Ifirmacombi
Croatian: Ako ste zaboravili uzeti Ifirmacombi
English: Irbesartan had no effect upon fertility of treated rats and their offspring up to the dose levels inducing the first signs of parental toxicity (see section 5.3).
Croatian: Irbesartan nije utjecao na fertilitet tretiranih štakora ili njihovog potomstva sve do onih doza koje izazivaju prve znakove toksičnosti u roditelja (vidjeti dio 5.3).
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded.
Croatian: Epidemiološki podaci koji se odnose na rizik od teratogenog učinka nakon primjene ACE inhibitora tijekom prvog tromjesečja nisu bili dostatni za donošenje zaključaka, međutim, manji porast rizika ne može se isključiti.
English: Not known: respiratory distress (including pneumonitis and pulmonary oedema)
Croatian: Nije poznato: respiratorni distres (uključujući pneumonitis i plućni edem)
English: Such conditions should be corrected before initiating therapy with Ifirmacombi.
Croatian: Takva stanja treba korigirati prije započinjanja terapije lijekom Ifirmacombi.
English: Ifirmacombi is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Croatian: Ifirmacombi se ne preporučuje majkama koje doje, a liječnik može izabrati drugu terapiju ako želite dojiti, osobito ako se radi o dojenju novorođenčeta ili nedonoščeta.
English: If you get any of the above symptoms or get short of breath, stop taking Ifirmacombi and contact your doctor immediately.
Croatian: Ako primijetite neki od tih simptoma ili ako osjetite nedostatak zraka, prestanite uzimati Ifirmacombi i odmah se javite svom liječniku.
English: Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy (see section 4.8).
Croatian: Čimbenici rizika razvoja akutnog glaukoma zatvorenog kuta mogu uključivati anamnezu alergije na sulfonamid ili penicilin (vidjeti dio 4.8).
English: Renal artery stenosis - Renovascular hypertension:
Croatian: Stenoza renalne arterije - Renovaskularna hipertenzija:
English: It is also important to tell your doctor if you are taking other medicines to reduce your blood pressure, steroids, and medicines to treat cancer, pain killers, arthritis medicines or colestyramine and colestipol resins for lowering blood cholesterol.
Croatian: Također je važno da obavijestite svog liječnika ako uzimate druge lijekove za sniženje krvnog tlaka, steroide te lijekove za liječenje raka, lijekove protiv bolova, lijekove za liječenje artritisa ili kolestiramin i smole kolestipola za snižavanje razine kolesterola u krvi.
English: Blister (OPA/Aluminium/PVC//Aluminium): 14, 28, 30, 56, 56 x 1, 84, 90 and 98 film-coated tablets, in a box.
Croatian: Blister (OPA/aluminij/PVC//aluminij): 14, 28, 30, 56, 56 x 1, 84, 90 i 98 filmom obloženih tableta, u kutiji.
English: If this medicine does not help to reduce your blood pressure as required, the doctor will prescribe additional treatment to you.
Croatian: Ako Vam ova doza ne pomogne u snižavanju krvnog tlaka koliko je potrebno, liječnik će Vam propisati dodatnu terapiju.
English: Children should not take Ifirmacombi
Croatian: Djeca ne smiju uzimati Ifirmacombi
English: Ifirmacombi is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Croatian: Ifirmacombi se ne preporučuje uzimati u ranoj trudnoći te se ne smije uzimati nakon trećeg mjeseca trudnoće jer može ozbiljno naškoditi Vašem djetetu uzimate li ga nakon trećeg mjeseca trudnoće.
English: abortion or early resorption was noted at doses causing significant maternal toxicity, including mortality.
Croatian: Abortus ili rana resorpcija opaženi su u kunića pri dozama koje su bile značajno toksične za majke, uključujući i smrtnost.
English: In patients with creatinine clearance < 20 ml/min, the elimination half-life of hydrochlorothiazide was reported to increase to 21 hours.
Croatian: U bolesnika čiji je klirens kreatinina < 20 ml/min zabilježeno je da se poluvrijeme eliminacije hidroklorotiazida povisi na 21 sat.
English: There is no difference in response to Ifirmacombi, regardless of age or gender.
Croatian: Ne postoji razlika u terapijskom odgovoru bolesnika na Ifirmacombi s obzirom na spol i dob.
English: Corticosteroids, ACTH: electrolyte depletion, particularly hypokalaemia, may be increased;
Croatian: Kortikosteroidi, ACTH: može se pojačati gubitak elektrolita, posebice hipokalijemija;
English: Boxes of 14, 28, 30, 56, 56 x 1, 84, 90 and 98 film-coated tablets in blisters are available.
Croatian: Dostupne su kutije s 14, 28, 30, 56, 56 x 1, 84, 90 i 98 filmom obloženih tableta u blisterima.
English: Because no information is available regarding the use of Ifirmacombi during breast-feeding, Ifirmacombi is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
Croatian: Budući da nema dostupnih podataka o upotrebi lijeka Ifirmacombi tijekom dojenja, ne preporučuje se njegova primjena tijekom dojenja i prednost treba dati drugoj terapiji s bolje ustanovljenim profilom sigurnosti primjene, osobito kada se doji novorođenče ili nedonošče.
English: 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 56 film-coated tablets 56 x 1 film-coated tablets 84 film-coated tablets 90 film-coated tablets 98 film-coated tablets
Croatian: 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 56 filmom obloženih tableta 56 x 1 filmom obloženih tableta 84 filmom obložene tablete 90 filmom obloženih tableta 98 filmom obloženih tableta
English: No specific information is available on the treatment of overdose with Ifirmacombi.
Croatian: Nema dostupnih specifičnih podataka o liječenju predoziranja lijekom Ifirmacombi.
English: Ifirmacombi is used to treat high blood pressure, when treatment with irbesartan or hydrochlorothiazide alone did not provide adequate control of your blood pressure.
Croatian: Ifirmacombi se primjenjuje za liječenje visokog krvnog tlaka kada liječenje samo irbesartanom ili samo hidroklorotiazidom ne osigurava odgovarajuću kontrolu krvnog tlaka.
English: Ifirmacombi has been rarely associated with symptomatic hypotension in hypertensive patients without other risk factors for hypotension.
Croatian: Ifirmacombi je rijetko povezan sa simptomatskom hipotenzijom u hipertenzivnih bolesnika koji nemaju druge rizične faktore koji bi uzrokovali hipotenziju.
English: Rare cases of allergic skin reactions (rash, urticaria), as well as localised swelling of the face, lips and/or tongue have been reported in patients taking irbesartan.
Croatian: Zabilježeni su rijetki slučajevi alergijskih kožnih reakcija (osip, urtikarija), kao i lokalizirano oticanje lica, usana i/ili jezika u bolesnika koji su uzimali irbesartan.
English: swelling extremity arthralgia, myalgia
Croatian: oticanje ekstremiteta artralgija, mialgija
English: Increases in cholesterol and triglyceride levels have been associated with thiazide diuretic therapy; however at the 12.5 mg dose contained in Ifirmacombi, minimal or no effects were reported.
Croatian: Povišenje razine kolesterola i triglicerida bilo je povezano s terapijom tiazidima, međutim, pri dozi od 12,5 mg, koliko sadrži Ifirmacombi, zabilježeni su minimalni učinci ili ih uopće nije bilo.
English: If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA.
Croatian: Ako se procijeni da je ponovna primjena diuretika neophodna, preporučuje se da se izložena područja kože zaštite od sunca ili umjetnog UVA zračenja.
English: Preparations containing lithium should not be taken with Ifirmacombi without close supervision by your doctor.
Croatian: Pripravci koji sadrže litij ne smiju se uzimati s lijekom Ifirmacombi bez pomnog liječničkog nadzora.
English: If hypotension occurs, the patient should be placed in a supine position, with salt and volume replacements given quickly.
Croatian: Ako se pojavi hipotenzija, bolesnika je potrebno položiti u ležeći položaj i brzo mu dati nadomjestke za natrij i volumen.
English: Irbesartan is excreted in the milk of lactating rats.
Croatian: Irbesartan se izlučuje u mlijeko ženki štakora u laktaciji.
English: Not known: electrolyte imbalance (including hypokalaemia and hyponatraemia, see section 4.4), hyperuricaemia, glycosuria, hyperglycaemia, increases in cholesterol and triglycerides
Croatian: Nije poznato: poremećaj ravnoteže elektrolita (uključujući hipokalijemiju i hiponatrijemiju, vidjeti dio 4.4), hiperuricemija, glikozurija, hiperglikemija, porast koncentracije kolesterola i triglicerida
English: dizziness orthostatic dizziness headache
Croatian: omaglica ortostatska omaglica glavobolja
English: In vitro studies indicate that irbesartan is primarily oxidised by the cytochrome P450 enzyme CYP2C9; isoenzyme CYP3A4 has negligible effect.
Croatian: In vitro ispitivanja upućuju da se irbesartan primarno oksidira pomoću enzima CYP2C9 citokroma P450, dok izoenzim CYP3A4 ima zanemariv učinak.
English: Due to the hydrochlorothiazide contained in Ifirmacombi, if you drink alcohol while on treatment with this medicine, you may have an increased feeling of dizziness on standing up, specially when getting up from a sitting position.
Croatian: Ako pijete alkohol za vrijeme liječenja ovim lijekom, zbog hidroklorotiazida u lijeku Ifirmacombi, možete imati pojačan osjećaj omaglice prilikom ustajanja, posebno kod ustajanja iz sjedećeg položaja.
English: When angiotensin II antagonists are administered simultaneously with non-steroidal antiinflammatory drugs (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Croatian: Kada se antagonisti angiotenzina II primjenjuju istodobno s nesteroidnim protuupalnim lijekovima (npr. selektivnim inhibitorima COX-2, acetilsalicilatnom kiselinom (> 3 g/dan) i neselektivnim nesteroidnim protuupalnim lijekovima) može doći do slabljenja antihipertenzivnog učinka.
English: Following oral administration of Ifirmacombi, the absolute oral bioavailability is 6080% and 50-80% for irbesartan and hydrochlorothiazide, respectively.
Croatian: Nakon peroralne primjene lijeka Ifirmacombi apsolutna oralna bioraspoloživost je 6080% za irbesartan, odnosno 50-80% za hidroklorotiazid.
English: Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts.
Croatian: Tiazidi djeluju na mehanizam reapsorpcije elektrolita u bubrežnim tubulima izravno pojačavajući izlučivanje natrija i klorida u približno jednakim količinama.
English: High HCTZ use (≥50,000 mg cumulative) was associated with an adjusted OR of 1.29 (95% CI: 1.231.35) for BCC and 3.98 (95% CI: 3.68-4.31) for SCC.
Croatian: Velika primjena hidroklorotiazida (≥50 000 mg kumulativno) bila je povezana s prilagođenim OR od 1,29 (95% CI: 1,23-1,35) za BCC i 3,98 (95% CI: 3,68-4,31) za SCC.
English: Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Croatian: Tiazide treba primjenjivati s oprezom u bolesnika s oštećenom funkcijom jetre ili progresivnom bolešću jetre jer male promjene ravnoteže tjelesnih tekućina i elektrolita mogu izazvati hepatičku komu.
English: The antihypertensive effect of Ifirmacombi may be increased with the concomitant use of other antihypertensive agents.
Croatian: Antihipertenzivni učinak lijeka Ifirmacombi može se pojačati istodobnim uzimanjem drugih antihipertenziva.
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypokalaemia, hyponatraemia, and hypochloremic alkalosis).
Croatian: Tiazidi, uključujući hidroklorotiazid, mogu uzrokovati neravnotežu tekućine ili elektrolita (hipokalijemiju, hiponatrijemiju i hipokloremijsku alkalozu).
English: Not known: fever
Croatian: Nije poznato: vrućica
English: Not known: hyperkalaemia
Croatian: Nije poznato: hiperkalijemija
English: Table 1: Adverse Reactions in Placebo-Controlled Trials and Spontaneous Reports Investigations
Croatian: Tablica 1: Nuspojave prikupljene u placebom kontroliranim ispitivanjima i spontanim prijavljivanjem Pretrage
English: The potential toxicity of the irbesartan/hydrochlorothiazide combination after oral administration was evaluated in rats and macaques in studies lasting up to 6 months.
Croatian: Potencijalna toksičnost kombinacije irbesartan/hidroklorotiazid nakon peroralne primjene ocijenjena je na štakorima i makaki majmunima, u ispitivanjima koja su trajala do 6 mjeseci.
English: Digitalis glycosides: thiazide induced hypokalaemia or hypomagnaesemia favour the onset of digitalis-induced cardiac arrhythmias (see section 4.4);
Croatian: Glikozidi digitalisa: tiazidima inducirana hipokalijemija ili hipomagnezijemija potiču pojavu srčanih aritmija uzrokovanih digitalisom (vidjeti dio 4.4);
English: Most of the above mentioned effects appear to be due to the pharmacological activity of irbesartan (blockade of angiotensin-II-induced inhibition of renin release, with stimulation of the renin-producing cells) and occur also with angiotensin converting enzyme inhibitors.
Croatian: Čini se da je većina gore spomenutih učinaka povezana s farmakološkim učinkom irbesartana (blokada angiotenzin-II-inducirane inhibicije otpuštanja renina uz stimulaciju stanica koje proizvode renin) te da se pojavljuju i pri primjeni inhibitora angiotenzin konvertirajućeg enzima.
English: (creatine kinase) or raised levels of substances that measure kidney function (blood urea nitrogen, creatinine).
Croatian: (kreatin kinaza) ili povišene razine tvari u krvi koje su pokazatelj funkcije bubrega (dušik iz ureje u krvi, kreatinin).
English: Efficacy and safety of the combination of irbesartan and hydrochlorothiazide as initial therapy for severe hypertension (defined as SeDBP ≥ 110 mmHg) was evaluated in a multicentre, randomized, double-blind, active-controlled, 8-week, parallel-arm study.
Croatian: Učinkovitost i sigurnost primjene kombinacije irbesartana i hidroklorotiazida kao inicijalne terapije za tešku hipertenziju (dijastolički tlak u sjedećem položaju ≥ 110 mmHg) ocijenjena je u multicentričnom, randomiziranom, dvostruko slijepom ispitivanju s aktivnom kontrolom, u trajanju od 8 tjedana, s paralelnom skupinom.
English: Sulfonamide drugs or sulfonamide derivative drugs can cause an idiosyncratic reaction, resulting in transient myopia and acute angle-closure glaucoma.
Croatian: Sulfonamidi ili derivati sufonamida mogu uzrokovati idiosinkratičnu reakciju uzrokujući prolaznu miopiju i akutni glaukom zatvorenog kuta.
English: Therefore, the use of Ifirmacombi is not recommended.
Croatian: Primjena lijeka Ifirmacombi se, stoga, ne preporučuje.
English: Diuretic agents such as the hydrochlorothiazide contained in Ifirmacombi may have an effect on other medicines.
Croatian: Diuretici, kao što je hidroklorotiazid iz lijeka Ifirmacombi, mogu imati učinke na druge lijekove.
English: Not known: Anaphylactic reaction including anaphylactic shock
Croatian: Nepoznato: anafilaktička reakcija uključujući anafilaktički šok
English: Not known: cough
Croatian: Nije poznato: kašalj
English: Food does not affect the bioavailability of Ifirmacombi.
Croatian: Hrana ne utječe na bioraspoloživost lijeka Ifirmacombi.
English: Studies in animals indicate that the radiolabelled irbesartan is detected in rat and rabbit foetuses.
Croatian: Ispitivanja na životinjama pokazuju da je radioaktivno obilježeni irbesartan utvrđen u fetusa štakora i kunića.
English: Among 898 hypertensive patients who received various doses of irbesartan/hydrochlorothiazide (range: 37.5 mg/6.25 mg to 300 mg/25 mg) in placebo-controlled trials, 29.5% of the patients experienced adverse reactions.
Croatian: Od 898 hipertenzivnih bolesnika koji su primali različite doze irbesartana/hidroklorotiazida (raspon: od 37,5 mg/6,25 mg do 300 mg/25 mg) u placebom kontroliranim kliničkim ispitivanjima u 29,5% bolesnika zabilježene su nuspojave.
English: The total body and renal clearance are 157-176 and 3.0-3.5 ml/min, respectively.
Croatian: Sveukupni tjelesni klirens iznosi 157-176, a bubrežni 3-3,5 ml/min.
English: After either oral or intravenous administration of
Croatian: Nakon peroralne ili intravenske primjene
English: Not known: jaundice (intrahepatic cholestatic jaundice)
Croatian: Nije poznato: žutica (intrahepatička kolestatska žutica)
English: Common: Uncommon: Not known:
Croatian: Često: Manje često: Nije poznato:
English: The primary objective of this study was to compare the proportion of patients whose SeDBP was controlled (SeDBP < 90 mmHg) at Week 5 of treatment.
Croatian: Primarni cilj ispitivanja bio je usporediti udio bolesnika čiji je dijastolički krvni tlak u sjedećem položaju bio kontroliran (< 90 mmHg) u 5. tjednu liječenja.
English: You can take Ifirmacombi with or without food.
Croatian: Ifirmacombi se može uzimati s hranom ili bez.
English: The effects of the irbesartan/hydrochlorothiazide combination on fertility have not been evaluated in animal studies, as there is no evidence of adverse effect on fertility in animals or humans with either irbesartan or hydrochlorothiazide when administered alone.
Croatian: U ispitivanjima na životinjama nije evaluiran učinak kombinacije irbesartana/hidroklorotiazida na fertilitet jer nema dokaza o neželjenim učincima na fertilitet životinja ili ljudi ni irbesartana ni hidroklorotiazida kad se primjenjuju kao monoterapija.
English: Irbesartan prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax and the blood pressure to lower.
Croatian: Irbesartan sprječava vezanje angiotenzina II na te receptore uzrokujući opuštanje krvnih žila i sniženje krvnog tlaka.
English: Conversely, due to the irbesartan component of Ifirmacombi hyperkalaemia might occur, especially in the presence of renal impairment and/or heart failure, and diabetes mellitus.
Croatian: Nasuprot tomu, zbog irbesartana u sastavu lijeka Ifirmacombi može se pojaviti hiperkalijemija, posebice ako istodobno postoji narušena funkcija bubrega i/ili srčano zatajenje i diabetes mellitus.
English: The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium.
Croatian: Diuretsko djelovanje hidroklorotiazida smanjuje volumen plazme, pojačava aktivnost renina u plazmi, pojačava sekreciju aldosterona s posljedičnim pojačanim gubitkom kalija i bikarbonata urinom te sniženjem koncentracije kalija u serumu.
English: These lesions were not observed in macaques; - decreases in serum potassium due to hydrochlorothiazide and partly prevented when hydrochlorothiazide was given in combination with irbesartan.
Croatian: Te promjene nisu zabilježene u makaki majmuna; - smanjenje razine kalija u serumu koje izaziva hidroklorotiazid djelomično je smanjeno kad se hidroklorotiazid davao u kombinaciji s irbesartanom.
English: Not known: anaphylactic reactions, toxic epidermal necrolysis, necrotizing angitis (vasculitis, cutaneous vasculitis), cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, photosensitivity reactions, rash, urticaria
Croatian: Nije poznato: anafilaktičke reakcije, toksična epidermalna nekroliza, nekrotizirajući angitis (vaskulitis, kožni vaskulitis), kožne reakcije slične eritemskom lupusu, reaktivacija kožnog eritemskog lupusa, reakcije fotoosjetljivosti, osip, urtikarija
English: Based on the pharmacological mechanism of action of hydrochlorothiazide its use during the second and third trimester may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterus, disturbance of electrolyte balance and thrombocytopenia.
Croatian: Na osnovi farmakološkog mehanizma djelovanja hidroklorotiazida može se zaključiti da njegova primjena u drugom i trećem tromjesečju trudnoće može ugroziti feto-placentalnu perfuziju i uzrokovati nuspojave u fetusa i novorođenčadi poput žutice, poremećaja ravnoteže elektrolita i trombocitopenije.
English: No dosage adjustment of Ifirmacombi is necessary in older people.
Croatian: Nije potrebno prilagođavati dozu lijeka Ifirmacombi u starijih osoba.
English: Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy:
Croatian: Stenoza aortnog i mitralnog zaliska, opstruktivna hipertrofična kardiomiopatija:
English: Other medicines and Ifirmacombi
Croatian: Drugi lijekovi i Ifirmacombi
English: What Ifirmacombi contains - The active substances are irbesartan and hydrochlorothiazide.
Croatian: Što Ifirmacombi sadrži - Djelatne tvari su irbesartan i hidroklorotiazid.
English: There is no experience regarding the administration of Ifirmacombi in patients with recent kidney transplantation.
Croatian: Nema iskustava s primjenom lijeka Ifirmacombi u bolesnika kojima je nedavno transplantiran bubreg.
English: Based on its pharmacodynamic properties, Ifirmacombi is unlikely to affect the ability to drive and use machines.
Croatian: Na temelju farmakodinamičkih svojstava, nije vjerojatno da će Ifirmacombi utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Table 3: Adverse reactions reported with the use of hydrochlorothiazide alone Investigations
Croatian: Tablica 3: Nuspojave prijavljene pri primjeni samo hidroklorotiazida Pretrage
English: Plasma protein binding of irbesartan is approximately 96%, with negligible binding to cellular blood components.
Croatian: Oko 96% irbesartana veže se za proteine u plazmi sa zanemarivim vezanjem za krvne stanice.
English: increases in blood urea nitrogen (BUN), creatinine and creatine kinase decreases in serum potassium and sodium
Croatian: porast koncentracije BUN-a (dušik iz ureje u krvi), kreatinina i kreatin kinaze smanjenje koncentracije kalija i natrija u serumu
English: Ifirmacombi is unlikely to affect your ability to drive or use machines.
Croatian: Ifirmacombi ne bi trebao utjecati na Vašu sposobnost upravljanja vozilima i strojevima.
English: In non-clinical safety studies, high doses of irbesartan (≥ 250 mg/kg/day in rats and ≥ 100 mg/kg/day in macaques) caused a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit).
Croatian: U pretkliničkim ispitivanjima sigurnosti primjene visoke doze irbesartana (≥ 250 mg/kg/dan u štakora i ≥ 100 mg/kg/dan u makaki majmuna) uzrokovale su smanjenje vrijednosti crvenih krvnih stanica (eritrocita, hemoglobina, hematokrita).
English: Tables 2 and 3 below detail the adverse reactions reported with the individual components of Ifirmacombi.
Croatian: Tablice 2 i 3 prikazuju nuspojave prijavljene za pojedinačne komponente lijeka Ifirmacombi.