FrancophonIA/ELRC3.0 huggingface dataset:
English: Stribild can cause dizziness, tiredness or insomnia.
Slovenian: Zdravilo Stribild lahko povzroči omotičnost, utrujenost ali nespečnost.
English: What Stribild is and what it is used for What you need to know before you take Stribild How to take Stribild
Slovenian: Kaj je zdravilo Stribild in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Stribild Kako jemati zdravilo Stribild Možni neželeni učinki
English: If you are a woman with HIV it is recommended that you do not breast-feed to avoid passing the virus to the baby in breast milk.
Slovenian: Če ste ženska, okužena z virusom HIV, je priporočljivo, da ne dojite, da s tem preprečite prenos virusa preko mleka na dojenčka.
English: 2 Studies performed with ritonavir boosted elvitegravir.
Slovenian: 2 Študije izvedene z elvitegravirjem, okrepljenim z ritonavirjem.
English: Recommended dose for adults and adolescents aged 12 to less than 18 years who weigh at least 35 kg:
Slovenian: Priporočeni odmerek za odrasle in mladostnike, stare od 12 do 18 let, ki tehtajo vsaj 35 kg:
English: The difference in the proportion of patients who maintained < 400 copies/mL at week 48 was mainly influenced by the higher number of discontinuations in the tenofovir disoproxil treatment group.
Slovenian: Na razliko v deležu bolnikov, ki so ohranili < 400 kopij/ml v 48. tednu, je pretežno vplivalo večje število prekinitev v skupini zdravljenja z dizoproksiltenofoviratom.
English: (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100) or rare (≥ 1/10,000
Slovenian: Pogostnost je definirana kot zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100) ali redki neželeni učinki (≥ 1/10.000 do
English: Interactions between the components of Stribild and potential co-administered medicinal products are listed in Table 1 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”).
Slovenian: Interakcije med učinkovinami zdravila Stribild in možnimi sočasno uporabljenimi zdravili so navedene v preglednici 1 spodaj (povečanje je označeno z znakom “↑”, zmanjšanje z “↓”, brez spremembe z “↔”).
English: Before starting treatment, your doctor will order blood tests to assess your kidney function.
Slovenian: Pred začetkom zdravljenja bo zdravnik naredil krvne preiskave, da bo ocenil delovanje vaših ledvic.
English: If you have hepatitis B infection liver problems may become worse after you stop taking Stribild.
Slovenian: Če imate okužbo s hepatitisom B, se lahko težave z jetri poslabšajo, ko prenehate jemati zdravilo Stribild.
English: • breakdown of muscle, muscle pain or weakness
Slovenian: • razpad mišičnega tkiva, bolečine v mišicah ali mišična oslabelost
English: Most patients who developed resistance substitutions to elvitegravir developed resistance substitutions to both emtricitabine and elvitegravir.
Slovenian: Pri večini bolnikov, pri katerih so se razvile rezistenčne substitucije na elvitegravir, so se razvile rezistenčne substitucije na emtricitabin in elvitegravir.
English: Missing data during window but on study drug a Week 48 window is between Day 309 and 378 (inclusive).
Slovenian: < 50 kopij/mle V oknu podatki manjkajo, a uporablja študijsko zdravilo a Okno v 48. tednu je med 309 in 378 dnevom (vključno z njima).
English: • bronchodilators, used to treat asthma and other lung-related problems: salmeterol
Slovenian: • bronhodilatatorje, ki se uporabljajo za zdravljenje astme in drugih težav, povezanih s pljuči: salmeterol
English: The biotransformation of emtricitabine includes oxidation of the thiol moiety to form the 3'-sulfoxide diastereomers (~ 9% of dose) and conjugation with glucuronic acid to form 2'-O-glucuronide (~ 4% of dose).
Slovenian: Biotransformacija emtricitabina vključuje oksidacijo tiolnega dela molekule, pri čemer nastanejo 3'-sulfoksid diastereomere (~9 % odmerka) in konjugacijo z glukuronsko kislino, pri čemer nastane 2'-O-glukuronid (~4 % odmerka).
English: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infections (infections that occur in people with a weak immune system), signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Slovenian: Pri nekaterih bolnikih z napredovalo okužbo s HIV (AIDSom) in oportunističnimi okužbami v anamnezi (okužbe, ki se pojavijo pri ljudeh z oslabljenim imunskim sistemom), se lahko znaki in simptomi vnetja zaradi prejšnjih okužb pojavijo kmalu po začetku zdravljenja HIV.
English: In this study, the safety profile of Stribild was similar to that in adults (see section 4.8, Tabulated summary of adverse reactions).
Slovenian: V tej študiji je bil varnostni profil zdravila Stribild podoben kot pri odraslih (glejte poglavje 4.8, Povzetek neželenih učinkov v preglednici).
English: Tenofovir disoproxil may cause a reduction in BMD.
Slovenian: Dizoproksiltenofovirat lahko zmanjša BMD.
English: Pregnant women should not take Stribild.
Slovenian: Nosečnice zdravila Stribild ne smejo jemati.
English: Therefore Stribild should not be used during breast-feeding.
Slovenian: Zato se zdravilo Stribild med dojenjem ne sme uporabljati.
English: Ex vivo rabbit studies and in vivo dog studies suggest that cobicistat has a low potential for QT prolongation, and may slightly prolong the PR interval and decrease left ventricular function at concentrations at least 11-fold higher than the human exposure at the recommended 150 mg daily dose.
Slovenian: Študije pri kuncih ex vivo in pri psih in vivo kažejo, da ima kobicistat nizek potencial za podaljšanje intervala QT in da lahko nekoliko podaljša interval PR ter zmanjša delovanje levega prekata pri koncentracijah, ki so vsaj 11-krat višje kot izpostavljenost pri človeku ob priporočenem dnevnem odmerku 150 mg.
English: Relevant examples include cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jirovecii pneumonia.
Slovenian: Ustrezni primeri vključujejo citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami in s Pneumocystis jirovecii povzročena pljučnica.
English: No emergent resistance to Stribild was detected through Week 48.
Slovenian: Pojava rezistence na zdravilo Stribild do konca 48. tedna niso opazili.
English: Due to protocol violation, two patients with historical K103N substitutions discontinued early with HIV-1 RNA < 50 copies/mL.
Slovenian: Zaradi kršitve protokola sta bila dva bolnika s preteklo substitucijo K103N predčasno izključena s HIV-1 RNA < 50 kopij/ml.
English: Reduced susceptibility to elvitegravir was most commonly associated with the integrase substitutions T66I, E92Q and Q148R.
Slovenian: Zmanjšana občutljivost na elvitegravir je bila najbolj pogosto povezana s substitucijami integraze T66I, E92Q in Q148R.
English: As the effect of cationic complexation of elvitegravir cannot be excluded when Stribild is co-administered with multivitamin supplements, it is recommended to separate Stribild and multivitamin supplements dosing by at least 4 hours.
Slovenian: Ker učinkov kationske kompleksacije elvitegravira pri sočasni uporabi zdravila Stribild ni mogoče izključiti, se priporoča, da se dajanje zdravila Stribild in multivitaminskih dopolnil loči za vsaj 4 ure.
English: Virologic response was defined as achieving an undetectable viral load (< 50 HIV-1 RNA copies/mL, snapshot analysis).
Slovenian: Virološki odziv je bil opredeljen kot dosežena nezaznavna virusna obremenitev (< 50 HIV-1 RNA kopij/ml, analiza posnetka stanja).
English: Tenofovir disoproxil should be avoided in patients with HIV-1 harbouring the K65R substitution.
Slovenian: Uporabi dizoproksiltenofovirata se je potrebno izogniti pri bolnikih s HIV-1, nosilci substitucije K65R.
English: Signs of osteonecrosis are: joint stiffness joint aches and pains (especially of the hip, knee and shoulder) difficulty with movement
Slovenian: Znaki osteonekroze so: - togost sklepov - bolečine (zlasti v kolkih, kolenih in ramenih) - težave pri gibanju
English: However increased postimplantation loss and decreased foetal weights were observed in rats associated with significant decreases in maternal body weights at 125 mg/kg/day.
Slovenian: Vendar pa so pri podganah opazili večjo izgubo po ugnezditvi in manjšo telesno maso plodov, povezano z značilnimi zmanjšanji materine telesne mase s 125 mg/kg/dan.
English: Twenty patients from these studies who switched to Stribild had the NNRTI-associated K103N substitution in their historical genotype prior to starting initial antiretroviral therapy.
Slovenian: Dvajset bolnikov iz teh študij, ki so prešli na zdravilo Stribild, je imelo v svojem preteklem genotipu substitucijo K103N, povezano z NNRTI, pred začetkom uvodne protiretrovirusne terapije.
English: If you are taking an antacid such as aluminium/magnesium hydroxide or a multivitamin supplement, take it at least 4 hours before or at least 4 hours after Stribild.
Slovenian: Če jemljete antacid, kot je aluminijev/magnezijev hidroksid ali multivitaminsko dopolnilo, ga vzemite vsaj 4 ure pred uporabo zdravila Stribild ali najmanj 4 ure po tem.
English: c Includes subjects who had ≥ 50 copies/mL in the Week 48 or Week 144 window, subjects who discontinued early due to lack or loss of efficacy, subjects who discontinued for reasons other than an adverse event, death or lack or loss of efficacy and at the time of discontinuation had a viral value of ≥ 50 copies/mL.
Slovenian: c Vključuje osebe, ki so imele v oknu 48. ali 144. tedna ≥ 50 kopij/ml, osebe, ki so predčasno prekinile sodelovanje zaradi pomanjkanja ali izgube učinka, osebe, ki so sodelovanje prekinile zaradi drugih razlogov, kot so neželeni učinki, smrt ali pomanjkanje oz. izguba učinka in so imele v času prekinitve virološko vrednost ≥ 50 kopij/ml.
English: Patients were randomised in a 2:1 ratio to either switch to Stribild or stay on their baseline antiretroviral regimen (SBR) for 48 weeks.
Slovenian: Bolniki so bili randomizirani v razmerju 2:1 na bodisi prehod na zdravilo Stribild ali nadaljevanje svojega izhodiščnega protiretrovirusnega režima (SBR - baseline antiretroviral regimen) za 48 tednov.
English: If overdose occurs the patient must be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Slovenian: V primeru prevelikega odmerka je potrebno pri bolniku nadzorovati znake toksičnosti (glejte poglavje 4.8) in mu nuditi standardno podporno zdravljenje.
English: However, in case of initiation of Stribild in patients previously taking didanosine or discontinuation of Stribild and change to a regimen including didanosine there could be a short period when measurable plasma levels of didanosine and tenofovir occur.
Slovenian: Vendar pa se lahko v primeru uvedbe zdravila Stribild pri bolnikih, ki so predhodno uporabljali didanozin, ali ki so prenehali uporabljati zdravilo Stribild in pri spremembi režima z vključitvijo didanozina, lahko pojavi kratko obdobje, v katerem so ravni didanozina ali tenofovirja v plazmi merljive.
English: Bone toxicity was diagnosed as osteomalacia (monkeys) and reduced bone mineral density (rats and dogs).
Slovenian: Toksičen vpliv na kosti je bil diagnosticiran kot osteomalacija (pri opicah) in kot zmanjšana mineralna gostota kosti (podgane in psi).
English: Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI).
Slovenian: Elvitegravir je zaviralec prenosa zapisa integraze HIV-1 (Integrase Strand Transfer Inhibitor, INSTI).
English: The laboratory findings in these 4 subjects with evidence of proximal tubulopathy improved without clinical consequence upon discontinuation of Stribild, but did not completely resolve in all subjects.
Slovenian: Laboratorijski izsledki pri teh 4 osebah z znaki proksimalne tubulopatije so se po prekinitvi uporabe zdravila Stribild popravili brez kliničnih posledic, vendar pa niso pri vseh osebah povsem izzveneli.
English:  Tell your doctor immediately about new or unusual symptoms after you stop treatment, particularly symptoms you associate with hepatitis B infection (such as yellowing of your skin or the white part of your eyes, dark “tea-coloured” urine, light-coloured stools, loss of appetite for several days or longer, feeling or being sick, or stomach-area pain).
Slovenian:  Nemudoma obvestite zdravnika o vsakem novem ali nenavadnem simptomu potem, ko ste prenehali z zdravljenjem, še posebej o simptomih, ki jih povezujete z okužbo s hepatitisom B (kot so porumenela koža ali beločnice, temen »čajno obarvan« urin, svetlo obarvano blato, večdnevna ali daljša izguba apetita, slabost ali bruhanje ali bolečine v trebuhu).
English: Reductions in BMD have been reported in paediatric patients.
Slovenian: Pri pediatričnih bolnikih so poročali o zmanjšanju BMD.
English: If a patient misses a dose of Stribild by more than 18 hours and it is almost time for the next dose, the patient should not take the missed dose and simply resume the usual dosing schedule.
Slovenian: Če bolnik izpusti odmerek zdravila Stribild za več kot 18 ur in je že skoraj čas za naslednji odmerek, naj bolnik ne nadomesti izpuščenega odmerka in preprosto nadaljuje z jemanjem po običajnem režimu odmerjanja.
English: EU/1/13/830/001 30 film-coated tablets EU/1/13/830/002 90 (3 bottles of 30) film-coated tablets
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/13/830/001 30 filmsko obloženih tablet EU/1/13/830/002 90 (3 plastenke po 30) filmsko obloženih tablet
English: Stribild comes in bottles of 30 tablets (with a silica gel desiccant that must be kept in the bottle to help protect your tablets).
Slovenian: Zdravilo Stribild je na voljo v plastenkah po 30 tablet (s silikagelskim sušilnim sredstvom, ki mora ostati v vsebniku zaradi zaščite tablet).
English: The Stribild renal educational brochure for prescribers of adolescent patients shall contain the following key safety messages:
Slovenian: Izobraževalna brošura o obravnavi ledvic za zdravilo Stribild za zdravnike, ki zdravilo predpisujejo mladostnikom, mora vsebovati naslednja ključna varnostna sporočila:
English: There is no specific antidote for overdose with Stribild.
Slovenian: Specifičnega antidota za preveliko odmerjanje zdravila Stribild ni.
English: The median terminal plasma half-life of elvitegravir following administration of Stribild is approximately 12.9 hours.
Slovenian: Mediana končna razpolovna doba elvitegravirja v plazmi po uporabi zdravila Stribild je približno 12,9 ur.
English: Elderly patients are more likely to have decreased renal function, therefore caution should be exercised when treating elderly patients with Stribild.
Slovenian: Verjetnost, da je ledvična funkcija pri starejših bolnikih zmanjšana, je večja, zato je pri zdravljenju starejših bolnikov z zdravilom Stribild potrebna previdnost.
English: It is recommended to separate Stribild and antacid administration by at least 4 hours.
Slovenian: Priporoča se, da se dajanje zdravila Stribild in antacida loči za vsaj 4 ure.
English: HIV-1 with the raltegravir-selected substitutions T66A/K, Q148H/K, and N155H showed cross-resistance to elvitegravir.
Slovenian: HIV-1 z raltegravirjem izbranimi substitucijami T66A/K, Q148H/K in N155H je pokazal navzkrižno rezistenco na elvitegravir.
English: Pharmacokinetics of elvitegravir, cobicistat, emtricitabine and tenofovir have not been evaluated in the elderly (over 65 years).
Slovenian: Farmakokinetičnih lastnosti elvitegravirja, kobicistata, emtricitabina in tenofovirja pri starejših (starih nad 65 let) niso ovrednotili.
English: In infants and children older than 4 months, the majority of patients taking emtricitabine achieved or maintained complete suppression of plasma HIV-1 RNA through 48 weeks (89% achieved ≤ 400 copies/ml and 77% achieved ≤ 50 copies/ml).
Slovenian: Pri dojenčkih in otrocih, starejših od 4 mesece, je večina bolnikov, ki je jemala emtricitabin, dosegla ali ohranila popolno supresijo plazemske RNA HIV-1 do konca 48. tedna (89 % je doseglo ≤ 400 kopij/ml in 77 % je doseglo ≤ 50 kopij/ml).
English: Do not stop taking Stribild
Slovenian: Ne prenehajte jemati zdravila Stribild
English: AUC: ↑
Slovenian: Pričakovano drospirenon: AUC: ↑
English: Voxilaprevir (400 mg/100 mg/ 100 mg+100 mg once daily)6 +
Slovenian: voksilaprevir (400 mg/100 mg/ 100 mg+100 mg enkrat dnevno)6 +
English: Findings in repeat-dose toxicity studies in rats, dogs and monkeys at exposure levels greater than or equal to clinical exposure levels and with possible relevance to clinical use included kidney and bone changes and a decrease in serum phosphate concentration.
Slovenian: Izsledki iz študij toksičnosti pri ponavljajočih se odmerkih pri podganah, psih in opicah pri stopnjah izpostavljenosti, ki so bile večje ali enake stopnjam klinične izpostavljenosti, in ki so morda pomembne za klinično uporabo, vključujejo spremembe ledvic in kosti in zmanjšanje koncentracije serumskega fosfata.
English: Some patients taking combination antiretroviral medicines such as Stribild may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki jemljejo kombinirana protiretrovirusna zdravila, kot je zdravilo Stribild, se lahko pojavi bolezen kosti, imenovana osteonekroza (odmiranje kostnega tkiva kot posledica pomanjkanja oskrbe kosti s krvjo).
English: Patients who failed treatment with Stribild and who had HIV-1 with emergent Stribild resistance substitutions harboured virus that remained susceptible to all PIs, NNRTIs, and most other NRTIs.
Slovenian: Bolniki, neuspešno zdravljeni z zdravilom Stribild, in ki so imeli HIV-1 s pojavom rezistenčnih substitucij proti zdravilu Stribild, so bili nosilci virusa, ki je ostal občutljiv na vse PI, NNRTI in večino drugih NRTI.
English: In studies GS-US-236-0102 and GS-US-236-0103, decreases in estimated creatinine clearance occurred early in treatment with Stribild, after which they stabilised.
Slovenian: V študijah GS-US-236-0102 in GS-US-236-0103 se je znižanje ocenjenega očistka kreatinina pojavilo zgodaj v poteku zdravljenja z zdravilom Stribild, nato pa se je stabiliziralo.
English: Patients had to be stably suppressed for at least six months prior to study entry, have no current or past history of resistance to the antiretroviral components of Stribild, and have HIV-1 RNA < 50 copies/mL at screening.
Slovenian: Bolniki so morali biti stabilno supresirani vsaj zadnjih šest mesecev pred vstopom v študijo, niso smeli imeti trenutne ali pretekle rezistence na protiretrovirusne komponente zdravila Stribild in so morali imeti HIV-1 RNA < 50 kopij/ml ob presejanju.
English: In addition to the adverse reactions reported in adults, anaemia (9.5%) and skin discolouration (31.8%) occurred more frequently in clinical trials in paediatric patients than in adults (see section 4.8, Tabulated summary of adverse reactions).
Slovenian: Poleg neželenih učinkov, o katerih so poročali pri odraslih, sta se anemija (9,5 %) in sprememba obarvanosti kože (31,8 %) pogosteje pojavljala v kliničnih preskušanjih pri pediatričnih bolnikih kot pri odraslih (glejte poglavje 4.8, Povzetek neželenih učinkov v preglednici).
English: When administering with Stribild, the maximum daily dose of itraconazole should not exceed 200 mg per day.
Slovenian: Pri dajanju z zdravilom Stribild največji dnevni odmerek itrakonazola ne sme preseči 200 mg dnevno.
English: Of these discontinuations, 7 in the Stribild group and 1 in the ATV/r+FTC/tenofovir disoproxil group occurred during the first 48 weeks.
Slovenian: Med temi prekinitvami je do 7 v skupini z zdravilom Stribild in 1 v skupini z ATV/r+FTC/dizoproksiltenofoviratom prišlo v prvih 48 tednih.
English: elevated amylase including elevated pancreatic amylase1, elevated serum lipase1, abdominal pain, dyspepsia, constipation, abdominal distension1, flatulence
Slovenian: zvišana amilaza vključno s povišano pankreazno amilazo1, povišanje serumske lipaze1, bolečine v trebuhu, dispepsija, konstipacija, abdominalna distenzija1, flatulenca
English: • suicidal ideation and suicide attempt (in patients who have had depression or mental health problems before), depression
Slovenian: • samomorilne misli in poskus samomora (pri bolnikih z depresijo ali psihiatrično boleznijo v preteklosti), depresija
English: Your doctor will also order blood tests during treatment to monitor your kidneys.
Slovenian: Zdravnik bo naredil krvne preiskave tudi v času zdravljenja, da bo nadzoroval stanje vaših ledvic.
English: Stribild contains lactose monohydrate.
Slovenian: Zdravilo Stribild vsebuje laktozo monohidrat.
English: For elvitegravir, Cmax and AUC increased 22% and 36% with a light meal, while increasing 56% and 91% with a high-fat meal, respectively.
Slovenian: Za elvitegravir se je Cmax zvišal za 22 % in AUC za 36 % pri lahkem obroku, pri obroku z visoko vsebnostjo maščobe pa za 56 % oz. 91 %.
English: Moreover, at concentrations substantially higher (approximately 300-fold) than those observed in vivo, tenofovir did not inhibit in vitro drug metabolism mediated by any of the major human CYP450 isoforms involved in drug biotransformation (CYP3A4, CYP2D6, CYP2C9, CYP2E1, or CYP1A1/2).
Slovenian: Nadalje tenofovir pri koncentracijah, znatno višjih (približno 300-krat) od tistih, ki so jih opazili in vivo, in vitro ni zaviral presnavljanja zdravil, pri katerem posreduje katera koli od pomembnejših izooblik glavnega humanega CYP450, ki sodelujejo pri biotransformaciji (CYP3A4, CYP2D6, CYP2C9, CYP2E1 ali CYP1A1/2).
English: • and you notice 18 hours or more after the time you usually take Stribild, then do not take the missed dose.
Slovenian: • in to opazite po 18 urah ali več od časa, ko običajno vzamete zdravilo Stribild, pozabljenega odmerka ne vzemite.
English: Exposures of cobicistat and emtricitabine in paediatric patients aged 12 to <18 years were similar to exposures achieved in adults.
Slovenian: Izpostavljenosti kobicistatu in emtricitabinu so bile pri pediatričnih bolnikih, starih od 12 do < 18 let, podobne kot izpostavljenosti, dosežene pri odraslih.
English: It is important not to miss a dose of Stribild.
Slovenian: Pomembno je, da ne pozabite vzeti nobenega odmerka zdravila Stribild.
English: The pharmacokinetics of emtricitabine have not been studied in subjects with hepatic impairment; however, emtricitabine is not significantly metabolised by liver enzymes, so the impact of liver impairment should be limited.
Slovenian: Farmakokinetičnih lastnosti emtricitabina niso proučevali pri osebah z jetrno okvaro, vendar jetrni encimi emtricitabina ne presnavljajo v pomembnem obsegu, zato je vpliv jetrne okvare verjetno omejen.
English: Based on drug interaction studies conducted with the components of Stribild, no clinically significant drug interactions have been either observed or are expected between the components of Stribild and the following medicinal products: entecavir, famciclovir, famotidine, omeprazole, ribavirin and sertraline.
Slovenian: Na podlagi študij medsebojnega delovanja z zdravilom, opravljenih z učinkovinami zdravila Stribild, klinično pomembnih interakcij med učinkovinami zdravila Stribild in naslednjimi zdravili bodisi niso opazili ali jih ni pričakovati: entekavir, famciklovir, famotidin, omeprazol, ribavirin in sertralin.
English: The use of Stribild in children below 12 years of age and who weigh less than 35kg has not been studied.
Slovenian: Uporabe zdravila Stribild pri otrocih, starih manj kot 12 let, ki tehtajo manj kot 35 kg, še niso preučili.
English: Elvitegravir plasma concentrations are lower with antacids due to local complexation in the gastrointestinal tract and not to changes in gastric pH.
Slovenian: Koncentracije elvitegravirja v plazmi so z antacidi nižje zaradi lokalne kompleksacije v prebavilih in ne zaradi sprememb vrednosti pH v želodcu.
English: Cobicistat is also a weak CYP2D6 inhibitor and is metabolised, to a minor extent, by CYP2D6.
Slovenian: Kobicistat je tudi šibak zaviralec CYP2D6, ki ga v manjšem obsegu presnavlja CYP2D6.
English: While taking Stribild you may still develop infections or other illnesses associated with HIV infection.
Slovenian: Med jemanjem zdravila Stribild se lahko pojavijo okužbe ali druge bolezni, povezane z okužbo z virusom HIV.