FrancophonIA/ELRC3.0 huggingface dataset:
English: if you are taking any of the following medicines used to treat high blood pressure:
Croatian: Nemojte više nikad uzimati Dafiro. ako uzimate bilo koji od lijekova navedenih u nastavku, koji se koriste za liječenje visokog krvnog tlaka:
English: In clinical studies in which amlodipine was administered in combination with beta blockers to patients with either hypertension or angina, no adverse effects on electrocardiographic parameters were observed.
Croatian: U kliničkim ispitivanjima u kojima je amlodipin primjenjivan u kombinaciji s betablokatorima u bolesnika ili s hipertenzijom ili anginom, nisu opaženi štetni učinci vezani uz elektrokardiografske parametre.
English: Absorption: Following oral administration of valsartan alone, peak plasma concentrations of valsartan are reached in 2-4 hours.
Croatian: Apsorpcija: Nakon peroralne primjene samo valsartana, vršne koncentracije valsartana u plazmi postižu se u 2-4 sata.
English: if you have narrowing of the aortic valve (aortic stenosis) or cardiogenic shock (a condition where your heart is unable to supply enough blood to the body).
Croatian: ako imate jako nizak krvni tlak (hipotenzija). ako imate suženje aortnog zaliska (stenoza aorte) ili kardiogeni šok (stanje u kojem Vaše srce ne može opskrbiti tijelo dovoljnom količinom krvi). ako patite od zatajivanja srca nakon srčanog udara.
English: In non-clinical safety studies, high doses of valsartan (200 to 600 mg/kg body weight) caused in rats a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit) and evidence of changes in renal haemodynamics (slightly raised blood urea nitrogen, and renal tubular hyperplasia and basophilia in males).
Croatian: U nekliničkim ispitivanjima sigurnosti, visoke doze valsartana (200 do 600 mg/kg tjelesne težine) u štakora su uzrokovale sniženje parametara crvenih krvnih stanica (eritrocita, hemoglobina, hematokrita) i dokazale promjene u hemodinamici bubrega (lagano povišen dušik iz ureje u krvi te bubrežna tubularna hiperplazija i bazofilija u mužjaka).
English: ACE inhibitors and ARBs should therefore not be used concomitantly in patients with diabetic nephropathy (see section 4.4).
Croatian: ACE inhibitori i ARB-ovi stoga se ne smiju istodobno primjenjivati u bolesnika s dijabetičkom nefropatijom (vidjeti dio 4.4).
English: If you experience any of these, tell your doctor straight away.
Croatian: Ako osjetite bilo što od navedenog, odmah obavijestite svog liječnika.
English: Use in patients with hypertension
Croatian: Primjena u hipertenzivnih bolesnika
English: In a clinical trial of patients with a history of dry cough during ACE inhibitor therapy, 19.5% of trial subjects receiving valsartan and 19.0% of those receiving a thiazide diuretic experienced coughing, compared to 68.5% of those treated with an ACE inhibitor (p <0.05).
Croatian: U kliničkom ispitivanju bolesnika s anamnezom suhog kašlja tijekom terapije ACE inhibitorom, kašalj se javio u 19,5% ispitanika koji su primali valsartan i u 19,0% ispitanika koji su primali tiazidni diuretik, u odnosu na 68,5% ispitanika liječenih ACE inhibitorom (p <0,05).
English: Absorption: After oral administration of therapeutic doses of amlodipine alone, peak plasma concentrations of amlodipine are reached in 6-12 hours.
Croatian: Apsorpcija: Nakon peroralne primjene terapijskih doza samo amlodipina, vršne koncentracije amlodipina u plazmi postižu se u 6-12 sati.
English: CARTON OF UNIT PACK
Croatian: KUTIJA JEDINIČNOG PAKIRANJA
English: ACE inhibitors or aliskiren (see also information under the headings “Do not take Dafiro” and “Warnings and precautions”); diuretics (a type of medicine also called “water tablets” which increases the amount of urine you produce); lithium (a medicine used to treat some types of depression); potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels; certain types of painkillers called non-steroidal anti-inflammatory medicines (NSAIDs) or selective cyclooxygenase-2 inhibitors (COX-2 inhibitors).
Croatian: ACE inhibitori ili aliskiren (vidjeti također informacije pod naslovom „Nemojte uzimati Dafiro“ i „Upozorenja i mjere opreza“); diuretici (vrsta lijeka koja se naziva i „tablete za mokrenje“ koje povećavaju količinu mokraće koju proizvodite); litij (lijek koji se koristi za liječenje nekih vrsta depresije); diuretici koji štede kalij, nadomjesci kalija, zamjene za sol koje sadrže kalij i ostale tvari koje mogu povećati razinu kalija; određene vrste lijekova protiv bolova koji se nazivaju nesteoridni protuupalni lijekovi (NSAILi) ili selektivnim inhibitorima ciklooksigenaze-2 (COX-2 inhibitori).
English: VA NEPHROND was a study in patients with type 2 diabetes mellitus and diabetic nephropathy.
Croatian: VA NEPHRON-D je bilo ispitivanje u bolesnika sa šećernom bolešću tipa 2 i dijabetičkom nefropatijom.
English: Administration of valsartan to patients with hypertension results in a drop in blood pressure without affecting pulse rate.
Croatian: Primjena valsartana u bolesnika s hipertenzijom rezultira sniženjem krvnog tlaka, bez utjecaja na brzinu pulsa.
English: If any of these apply to you, tell your doctor before taking Dafiro.
Croatian: Ako se bilo što od navedenog odnosi na Vas, obavijestite svog liječnika prije uzimanja Dafira.
English: Overdose with amlodipine may result in excessive peripheral vasodilation and, possibly, reflex tachycardia.
Croatian: Predoziranje amlodipinom može dovesti do izrazite periferne vazodilatacije te moguće refleksne tahikardije.
English: A randomised double-blind morbidity-mortality study called the Antihypertensive and LipidLowering treatment to prevent Heart Attack Trial (ALLHAT) was performed to compare newer therapies: amlodipine 2.5-10 mg/day (calcium channel blocker) or lisinopril 10-40 mg/day (ACEinhibitor) as first-line therapies to that of the thiazide-diuretic, chlorthalidone 12.5-25 mg/day in mild to moderate hypertension.
Croatian: Randomizirano dvostruko slijepo ispitivanje pobola i smrtnosti pod nazivom Antihipertenzivno i antilipidno liječenje u cilju sprečavanja srčanog udara (ALLHAT) provedeno je da bi se usporedile novije terapije: amlodipin 2,5-10 mg/dan (blokator kalcijevih kanala) ili lizinopril 10-40 mg/dan (ACE-inhibitor) kao terapije prve linije s terapijom tiazidnim diuretikom, klortalidonom 12,5-25 mg/dan u blagoj do umjerenoj hipertenziji.
English: Sensation of heaviness
Croatian: Osjećaj težine
English: Hypertonia
Croatian: Hipertonija
English: Weight increase
Croatian: Povećanje tjelesne težine
English: Dysgeusia
Croatian: Disgeuzija
English: Pack sizes: 7, 14, 28, 30, 56, 90, 98 or 280 film-coated tablets and multipacks containing 280 (4x70 or 20x14) film-coated tablets.
Croatian: Veličina pakiranja: 7, 14, 28, 30, 56, 90, 98 ili 280 filmom obloženih tableta i višestruko pakiranje koje sadrži 280 (4x70 ili 20x14) filmom obloženih tableta.
English: Both valsartan and amlodipine are unlikely to be removed by haemodialysis.
Croatian: I valsartan i amlodipin se ne mogu ukloniti hemodijalizom.
English: Kidney transplantation
Croatian: Transplantacija bubrega
English: Frequency Dafiro Amlodipine Valsartan
Croatian: Učestalost Dafiro Amlodipin Valsartan
English: Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels
Croatian: Diuretici koji štede kalij, nadomjesci kalija, zamjene soli koji sadrže kalij i ostale tvari koje mogu povećati razine kalija
English: Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (heparin, etc.) should be undertaken with caution and with frequent monitoring of potassium levels.
Croatian: Pri istodobnoj primjeni s nadomjescima kalija, diureticima koji štede kalij, zamjenama za sol koje sadrže kalij ili drugim lijekovima koji mogu povisiti razine kalija (heparin, itd.) nužan je oprez i često praćenje razina kalija.
English: Exfoliative dermatitis
Croatian: Eksfolijativni dermatitis
English: Adults with mild to moderate uncomplicated essential hypertension (mean sitting diastolic blood pressure 95 and <110 mmHg) were enrolled.
Croatian: Odrasle osobe s blagom do umjerenom nekompliciranom esencijalnom hipertenzijom (srednja vrijednost dijastoličkog krvnog tlaka u sjedećem položaju ≥95 i <110 mmHg) bile su uključene u ispitivanje.
English: Administration of amlodipine with grapefruit or grapefruit juice is not recommended as bioavailability may be increased in some patients, resulting in increased blood pressure lowering effects.
Croatian: Ne preporučuje se primjena amlodipina s grejpom ili sokom od grejpa jer bi u nekih bolesnika moglo doći do povećanja bioraspoloživosti, što rezultira pojačanim učinkom na snižavanje krvnog tlaka.
English: Discomfort, malaise
Croatian: Nelagoda, malaksalost
English: Dilated ureters were also found in the valsartan alone group (exposure 12 times the clinical dose of 160 mg valsartan).
Croatian: Dilatirani ureteri također su nađeni u skupini koja je bila samo na valsartanu (izloženost 12 puta veća od izloženosti kliničkom dozom od 160 mg valsartana).
English: The addition of valsartan 160 mg produced an additional reduction in systolic/diastolic blood pressure of 2.9/2.1 mmHg compared to patients who remained on amlodipine 10 mg only.
Croatian: Dodatak valsartana 160 mg doveo je do dodatnog sniženja sistoličkog/dijastoličkog krvnog tlaka za 2,9/2,1 mmHg, u usporedbi s bolesnicima koji su ostali samo na amlodipinu 10 mg.
English: 7 film-coated tablets 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 56 film-coated tablets 90 film-coated tablets 98 film-coated tablets 280 film-coated tablets 56x1 film-coated tablet (unit dose) 98x1 film-coated tablet (unit dose) 280x1 film-coated tablet (unit dose)
Croatian: 7 filmom obloženih tableta 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 56 filmom obloženih tableta 90 filmom obloženih tableta 98 filmom obloženih tableta 280 filmom obloženih tableta 56x1 filmom obloženih tableta (jedinična doza) 98x1 filmom obloženih tableta (jedinična doza) 280x1 filmom obloženih tableta (jedinična doza)
English: How to take Dafiro
Croatian: Kako uzimati Dafiro
English: Cellulose microcrystalline Crospovidone (type A) Silica, colloidal anhydrous Magnesium stearate
Croatian: Jezgra tablete celuloza, mikrokristalična krospovidon (tip A) silicijev dioksid, koloidni, bezvodni magnezijev stearat
English: Following administration of therapeutic doses to patients with hypertension, amlodipine produces vasodilation, resulting in a reduction of supine and standing blood pressures.
Croatian: Nakon primjene terapijskih doza bolesnicima s hipertenzijom, amlodipin dovodi do vazodilatacije, što rezultira sniženjem krvnog tlaka u ležećem i stojećem položaju.
English: For the single compounds there was no evidence of mutagenicity, clastogenicity or carcinogenicity.
Croatian: Nije bilo dokaza mutagenosti, klastogenosti ni karcinogenosti pojedinačnih komponenti.
English: Hepatic impairment Dafiro is contraindicated in patients with severe hepatic impairment (see section 4.3).
Croatian: Dafiro je kontraindiciran u bolesnika s teškim oštećenjem jetre (vidjeti dio 4.3).
English: Valsartan has been studied in patients with post myocardial infarction and heart failure.
Croatian: Valsartan je ispitivan u bolesnika nakon infarkta miokarda i u bolesnika sa zatajivanjem srca.
English: The addition of amlodipine 10 mg and 5 mg produced an additional reduction in systolic/diastolic blood pressure of 6.0/4.8 mmHg and 3.9/2.9 mmHg, respectively, compared to patients who remained on valsartan 160 mg only.
Croatian: Dodatak amlodipina 10 mg i 5 mg doveo je do dodatnog sniženja sistoličkog/dijastoličkog krvnog tlaka za 6,0/4,8 mmHg, odnosno 3,9/2,9 mmHg, u usporedbi s bolesnicima koji su ostali samo na valsartanu 160 mg.
English: Adverse reactions observed in animal studies with possible clinical relevance were as follows: Histopathological signs of inflammation of the glandular stomach was seen in male rats at an exposure of about 1.9 (valsartan) and 2.6 (amlodipine) times the clinical doses of 160 mg valsartan and 10 mg amlodipine.
Croatian: Nuspojave opažene u ispitivanjima na životinjama, s mogućim kliničkim značajem, bile su sljedeće: Histopatološki znakovi upale žljezdanog epitela želuca viđeni su u mužjaka štakora pri izloženosti od oko 1,9 (valsartan) i 2,6 (amlodipin) puta većima od izloženosti kliničkom dozom od 160 mg valsartana i 10 mg amlodipina.
English: Therefore, careful monitoring of serum lithium levels is recommended during concomitant use.
Croatian: Stoga, tijekom istodobne primjene preporučuje se pažljivo praćenje razina litija u serumu.
English: Common Somnolence, dizziness, palpitations, abdominal pain, nausea, ankle swelling.
Croatian: Somnolencija, omaglica, palpitacije, bol u abdomenu, mučnina, oticanje gležnjeva.
English: However, there was no significant difference in all-cause mortality between amlodipine-based therapy and chlorthalidone-based therapy RR 0.96 95% CI [0.89-1.02] p=0.20.
Croatian: Međutim, kad je riječ o smrtnosti od svih uzroka, između terapije temeljene na amlodipinu i terapije temeljene na klortalidonu nije bilo značajne razlike OR 0,96 95% CI [0,89-1,02] p=0,20.
English: Heart failure/post-myocardial infarction
Croatian: Zatajivanje srca/poslije infarkta miokarda
English: In this study (baseline blood pressure 171/113 mmHg), a Dafiro regimen of 5 mg/160 mg titrated to 10 mg/160 mg reduced sitting blood pressure by 36/29 mmHg as compared to 32/28 mmHg with a regimen of lisinopril/hydrochlorothiazide 10 mg/12.5 mg titrated to 20 mg/12.5 mg.
Croatian: U tom ispitivanju (početni krvni tlak 171/113 mmHg), liječenje Dafirom 5 mg/160 mg titriranim do 10 mg/160 mg snizilo je krvni tlak u sjedećem položaju za 36/29 mmHg, u usporedbi s 32/28 mmHg kod liječenja lizinoprilom/hidroklorotiazidom 10 mg/12,5 mg titriranim do 20 mg/12,5 mg.
English: Amlodipine is excreted in human milk .
Croatian: Amlodipin se izlučuje u mlijeko liječenih žena.
English: if you have had a kidney transplant or if you had been told that you have a narrowing of your kidney arteries.
Croatian: ako imate probleme s jetrom ili bubrezima. ako Vam je presađen bubreg ili ako Vam je rečeno da imate suženje bubrežnih arterija.
English: Dafiro should be discontinued immediately in patients who develop angioedema and should not be re-administered.
Croatian: Bolesnici u kojih se razvije angioedem trebaju odmah prekinuti primjenu Dafira i više ga ne smiju ponovo uzimati.
English: If any of these affect you severely, tell your doctor.
Croatian: Ako se bilo što od navedenog kod Vas pojavi u teškom obliku, obavijestite svog liječnika.
English: There are no clinical studies on fertility with Dafiro.
Croatian: Ne postoje klinička ispitivanja djelovanja Dafira na plodnost.
English: An increased incidence and severity of renal tubular basophilia/hyalinisation, dilation and casts, as well as interstitial lymphocyte inflammation and arteriolar medial hypertrophy were found at an exposure of 8-13 (valsartan) and 7-8 (amlodipine) times the clinical doses of 160 mg valsartan and 10 mg amlodipine.
Croatian: Nađena je povećana incidencija i težina bazofilije/hijalinizacije bubrežnih tubula, dilatacija i odljeva, kao i intersticijska limfocitna upala te medijalna hipertrofija arteriola pri izloženosti 8-13 (valsartan) i 7-8 (amlodipin) puta višim od izloženosti kliničkim dozama od 160 mg valsartana i 10 mg amlodipina.
English: Your doctor may also check your kidney function; anticonvulsant agents (e.g. carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone); St. John's wort; nitroglycerin and other nitrates, or other substances called “vasodilators”; medicines used for HIV/AIDS (e.g. ritonavir, indinavir, nelfinavir); medicines used to treat fungal infections (e.g. ketoconazole, itraconazole); medicines used to treat bacterial infections (such as rifampicin, erythromycin, clarithromycin, talithromycin); verapamil, diltiazem (heart medicines); simvastatin (a medicine used to control high cholesterol levels); dantrolene (infusion for severe body temperature abnormalities); medicines used to protect against transplant rejection (ciclosporin).
Croatian: Liječnik će Vam možda provjeriti i bubrežnu funkciju; antikonvulzivni lijekovi (npr. karbamazepin, fenobarbital, fenitoin, fosfenitoin, primidon); gospina trava; nitroglicerin i drugi nitrati, ili drugi lijekovi koji se nazivaju „vazodilatatori“; lijekovi koji se primjenjuju za liječenje HIV infekcije/SIDA (npr. ritonavir, indinavir, nelfinavir); lijekovi za liječenje gljivičnih infekcija (npr. ketokonazol, itrakonazol); lijekovi za liječenje bakterijskih infekcija (npr. rifampicin, eritromicin, klaritromicin, talitromicin); verapamil, diltiazem (lijekovi za srce); simvastatin (lijekovi koji se koriste za kontrolu visokih razina kolesterola); dantrolen (infuzija za teške poremećaje tjelesne temperature); lijekovi koji se koriste kao zaštita od odbacivanja transplantata (ciklosporin).
English: Caution should be exercised in patients with liver disease (see section 4.2).
Croatian: U bolesnika s bolešću jetre nužan je oprez (vidjeti dio 4.2).
English: Confusion
Croatian: Konfuzija
English: When switching eligible elderly hypertensive patients (see section 4.1) to amlodipine or Dafiro, the lowest available dose of amlodipine monotherapy or of the amlodipine component, respectively, should be used.
Croatian: Prilikom prebacivanja starijih hipertenzivnih bolesnika koji ispunjavaju uvjete za liječenje (vidjeti dio 4.1) na amlodipin ili Dafiro, treba se koristiti najniža dostupna doza amlodipina u monoterapiji ili amlodipina kao komponente.
English: Dafiro is indicated in adults whose blood pressure is not adequately controlled on amlodipine or valsartan monotherapy.
Croatian: Dafiro je indiciran u odraslih osoba čiji krvni tlak nije odgovarajuće kontroliran monoterapijom amlodipinom ili valsartanom.
English: Dafiro is used to treat high blood pressure in adults whose blood pressure is not controlled enough with either amlodipine or valsartan on its own.
Croatian: Dafiro se primjenjuje za liječenje povišenog krvnog tlaka u odraslih osoba čiji krvni tlak nije dovoljno kontroliran bilo samo amlodipinom ili samo valsartanom.
English: Excessive hypotension was seen in 0.4% of patients with uncomplicated hypertension treated with Dafiro in placebo-controlled studies.
Croatian: U placebo-kontroliranim ispitivanjima, u 0,4% bolesnika s nekompliciranom hipertenzijom liječenih Dafirom viđena je izražena hipotenzija.
English: Abdominal discomfort, abdominal pain upper
Croatian: Nelagoda u abdomenu, bol u gornjem abdomenu
English: Steady-state plasma levels are reached after continuous administration for 7-8 days.
Croatian: Stanje dinamičke ravnoteže razina u plazmi postiže se nakon kontinuirane primjene tijekom 78 dana.
English: Very rare Leukocytopenia, thrombocytopenia, allergic reactions, hyperglycaemia, hypertonia, peripheral neuropathy, myocardial infarction, arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation), vasculitis, pancreatitis, gastritis, gingival hyperplasia, hepatitis, jaundice, hepatic enzymes increased*, angioedema, erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke oedema, photosensitivity.
Croatian: Vrlo rijetko Leukocitopenija, trombocitopenija, alergijske reakcije, hiperglikemija, hipertonija, periferna neuropatija, infarkt miokarda, aritmija (uključujući bradikardiju, ventrikularnu tahikardiju i fibrilaciju atrija), vaskulitis, pankreatitis, gastritis, hiperplazija gingive, hepatitis, žutica, povišenje jetrenih enzima*, angioedem, multiformni eritem, urtikarija, eksfolijativni dermatitis, Stevens-Johnsonov sindrom, Quinckeov edem, fotosenzitivnost.
English: Tell your doctor if you are breast-feeding or about to start breast-feeding.
Croatian: Obavijestite svog liječnika ako dojite ili planirate početi dojiti.
English: Non-steroidal anti-inflammatory medicines (NSAIDs), including selective COX-2 inhibitors, acetylsalicylic acid (>3 g/day), and non-selective NSAIDs When angiotensin II antagonists are administered simultaneously with NSAIDs attenuation of the antihypertensive effect may occur.
Croatian: Nesteroidni protuupalni lijekovi (NSAILi), uključujući selektivne COX-2 inhibitore, acetilsalicilatnu kiselinu (>3 g/dan) i neselektivne NSAIL-e
English: Similar changes were also seen in the valsartan alone group (exposure 8.511.0 times the clinical dose of 160 mg valsartan).
Croatian: Slične su promjene nađene i u skupini koja je bila samo na valsartanu (izloženost 8,511,0 puta viša od izloženosti kliničkom dozom od 160 mg valsartana).
English: Other antihypertensive agents
Croatian: Drugi antihipertenzivni lijekovi
English: 5.2 Pharmacokinetic properties
Croatian: 5.2 Farmakokinetička svojstva Linearnost
English: Amlodipine stops calcium from moving into the blood vessel wall which stops the blood vessels from tightening.
Croatian: Amlodipin sprečava ulazak kalcija u stijenku krvne žile i tako sprečava sužavanje krvne žile.
English: Influenza
Croatian: Influenca
English: When switching eligible hypertensive patients (see section 4.1) with hepatic impairment to amlodipine or Dafiro, the lowest available dose of amlodipine monotherapy or of the amlodipine component, respectively, should be used.
Croatian: Prilikom prebacivanja hipertenzivnih bolesnika koji ispunjavaju uvjete za liječenje (vidjeti dio 4.1) s oštećenjem jetre na amlodipin ili Dafiro, treba se koristiti najniža dostupna doza amlodipina u monoterapiji ili amlodipina kao komponente.
English: How to store Dafiro
Croatian: Kako čuvati Dafiro
English: Caution should be exercised when administering Dafiro to patients with hepatic impairment or biliary obstructive disorders (see section 4.4).
Croatian: Nužan je oprez kod primjene Dafira bolesnicima s oštećenjem jetre ili opstruktivnim bolestima žučnog sustava (vidjeti dio 4.4).
English: Not known Decrease in haemoglobin, decrease in haematocrit, neutropenia, thrombocytopenia, increase of serum potassium, elevation of liver function values including increase of serum bilirubin, renal failure and impairment, elevation of serum creatinine, angioedema, myalgia, vasculitis, hypersensitivity including serum sickness.
Croatian: Nepoznato Sniženje hemoglobina, sniženje hematokrita, neutropenija, trombocitopenija, povišenje kalija u serumu, povišenje vrijednosti jetrenih funkcija uključujući povišenje bilirubina u serumu, zatajenje i oštećenje bubrega, povišenje kreatinina u serumu, angioedem, mialgija, vaskulitis, preosjetljivost uključujući serumsku bolest.
English: Other: dual blockade of the renin-angiotensin-aldosterone system (RAAS) Two large randomised, controlled trials (ONTARGET [ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial] and VA NEPHRON-D [The Veterans Affairs Nephropathy in Diabetes]) have examined the use of the combination of an ACE inhibitor with an ARB.
Croatian: ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) i VA NEPHRON-D (eng. The Veterans Affairs Nephropathy in Diabetes)) ispitivala su primjenu kombinacije ACE inhibitora s ARB-ovima.
English: Similar changes were found in the valsartan alone group (exposure 8.5-11.0 times the clinical dose of 160 mg valsartan).
Croatian: Slične promjene su također viđene u skupini koja je bila samo na valsartanu (izloženost 8,5-11,0 puta veća od izloženosti kliničkom dozom od 160 mg valsartana).
English: Oral use.
Croatian: Za peroralnu primjenu.
English: A vasoconstrictor may be helpful in restoring vascular tone and blood pressure,
Croatian: Vazokonstriktor može pomoći u ponovnoj uspostavi vaskularnog tonusa i krvnog tlaka, pod uvjetom da nema kontraindikacija za njegovu primjenu.
English: These doses in rats (600 mg/kg/day) are approximately 18 times the maximum recommended human dose on a mg/m basis (calculations assume an oral dose of
Croatian: Takve doze u štakora (600 mg/kg/dan) otprilike su 18 puta veće od najviše preporučene doze za ljude izražene u mg/m