FrancophonIA/ELRC3.0 huggingface dataset:
English: A population pharmacokinetics analysis of phase III studies in epileptic adult patients indicated that concomitant administration with valproate or levetiracetam did not affect the exposure to eslicarbazepine but this has not been verified by conventional interaction studies.
Slovenian: Analiza populacijske farmakokinetike v študijah III. faze pri odraslih bolnikih z epilepsijo je pokazala, da sočasno dajanje valproata ali levetiracetama ne vpliva na izpostavljenost eslikarbazepinu, vendar to ni bilo potrjeno z običajnimi študijami interakcij.
English: If you are not sure if the medicines you are taking could have this effect, discuss
Slovenian: Če niste prepričani, ali lahko katera koli zdravila, ki jih jemljete, imajo takšen učinek, se posvetujte z zdravnikom.
English: Presence of HLA-B*1502 allele in individuals of Han Chinese and Thai origin has been shown to be strongly associated with the risk of developing Stevens-Johnson syndrome (SJS) when treated with carbamazepine.
Slovenian: Pokazali so, da je prisotnost alela HLA-B*1502 pri posameznikih kitajske ali tajske narodnosti, ki prejemajo karbamazepin, tesno povezana s tveganjem za razvoj Stevens-Johnsonovega sindroma (SJS).
English: Symptoms include cold intolerance, large tongue, thin and brittle fingernails or hair and low body temperature.
Slovenian: Simptomi vključujejo slabo prenašanje mraza, povečanje jezika, tenke in krhke nohte ali lase ter nizko telesno temperaturo,
English: Adverse affects observed in animal studies occurred at exposure levels appreciably lower than the clinical exposure levels to eslicarbazepine (the principal and pharmacologically active metabolite of eslicarbazepine acetate).
Slovenian: Neželeni učinki, ki so jih opazili v študijah pri živalih, so se pojavili pri ravneh izpostavljenosti, ki so bile znatno nižje kot klinične ravni izpostavljenosti eslikarbazepinu (glavnemu in farmakološko aktivnemu presnovku eslikarbazepinacetata).
English: If you have kidney problems you will usually be given a lower dose of Exalief.
Slovenian: Če imate težave z ledvicami, vam bodo ponavadi dali manjši odmerek zdravila Exalief.
English: The pharmacokinetics of eslicarbazepine has not been evaluated in patients with severe hepatic impairment (see section 4.4 and 5.2) and use in these patients is therefore not recommended.
Slovenian: Pri bolnikih s hudo jetrno okvaro farmakokinetike eslikarbazepina niso ocenili (glejte poglavji 4.4 in 5.2), zato uporaba pri teh bolnikih ni priporočljiva.
English: 400 mg dose once daily for one or two weeks, before increasing to the maintenance dose.
Slovenian: 400 mg enkrat na dan en ali dva tedna, nato se odmerek zveča na vzdrževalni odmerek.
English: In the table below all adverse reactions, which occurred at an incidence greater than placebo and numerically present in more than 1 patient are listed by System Organ Class and frequency: very common ≥1/10, common ≥1/100 to <1/10, uncommon ≥1/1,000 to <1/100, rare ≥1/10,000 to <1/1,000.
Slovenian: V spodnji preglednici so neželeni učinki, ki so bili pogostejši kot pri jemanju placeba in ki so se pojavili pri več kot enem bolniku, navedeni po organskih sistemih in pogostnosti: zelo pogoste ≥ 1/10, pogoste ≥ 1/100 do < 1/10, občasne ≥ 1/1.000 do < 1/100, redke ≥ 1/10.000 do < 1/1.000).
English: Bleeding disorders in the newborn caused by antiepileptic medicinal products have been reported.
Slovenian: Pri novorojencih so poročali o motnjah strjevanja krvi, ki so jih povzročili antiepileptiki.
English: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugal
Slovenian: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugalska
English: The recommended starting dose is 400 mg once daily which should be increased to 800 mg once daily after one or two weeks.
Slovenian: Običajni začetni odmerek je 400 mg enkrat na dan, zvečati pa ga je treba do 800 mg enkrat na dan po enem ali dveh tednih.
English: Additional non-hormonal forms of contraception are recommended when using Exalief (see section 4.5 and 4.6).
Slovenian: Ob uporabi zdravila Exalief so priporočene dodatne nehormonske oblike kontracepcije (glejte poglavji 4.5 in 4.6).
English: Concomitant use of Exalief with oxcarbazepine is not recommended because this may cause overexposure to the active metabolites.
Slovenian: Sočasna uporaba zdravila Exalief in okskarbazepina ni priporočena, ker lahko povzroči preveliko izpostavljenost aktivnim presnovkom.
English: A small number of people being treated with anti-epileptics have had thoughts of harming or killing themselves.
Slovenian: Majhno število ljudi, ki jemljejo antiepileptike, ima misli o samopoškodbah in samomorilne misli.
English: • Crying, feeling depressed, nervous or confused, lack of interest or emotion
Slovenian: • jok, potrtost, živčnost ali zmedenost, pomanjkanje zanimanja ali občutkov,
English: In placebo-controlled studies involving 1,192 adult patients with partial-onset seizures (856 patients treated with eslicarbazepine acetate and 336 treated with placebo), 45.3% of patients treated with eslicarbazepine acetate and 24.4% of patients treated with placebo experienced adverse reactions.
Slovenian: V študijah, nadzorovanih s placebom, v katerih je sodelovalo 1.192 odraslih bolnikov s parcialnimi epileptičnimi napadi (856 bolnikov je prejemalo eslikarbazepinacetat, 336 pa placebo), so se neželeni učinki pojavili pri 45,3 % bolnikov, ki so prejemali eslikarbazepinacetat, in pri 24,4 % bolnikov, ki so prejemali placebo.
English: No change in exposure to carbamazepine or its metabolite carbamazepine-epoxide was noted.
Slovenian: Spremembe v izpostavljenosti karbamazepinu ali njegovemu presnovku karbamazepinepoksidu pa niso zaznali.
English: Some patients might experience dizziness, somnolence or visual disorders, particularly on initiation of treatment.
Slovenian: Pri nekaterih bolnikih se lahko pojavijo omotica, somnolenca ali motnje vida, zlasti ob začetku zdravljenja.
English: This time delay must be taken into account when Exalief is being used just prior to or in combination with other medicines that require dose adjustment when co-administered with Exalief.
Slovenian: Ta časovni zamik je treba upoštevati, kadar se zdravilo Exalief uporablja tik pred drugimi zdravili, pri katerih je ob sočasni uporabi z zdravilom Exalief treba prilagoditi odmerek, ali v kombinaciji z njimi.
English: • Reduction in blood platelets which increases risk of bleeding or bruising
Slovenian: • zmanjšanje števila trombocitov, ki zveča tveganje za krvavitve ali modrice,
English: * In patients concomitantly treated with carbamazepine and eslicarbazepine acetate in placebo-controlled studies, diplopia, abnormal coordination and dizziness were reported more frequently.
Slovenian: * Pri bolnikih, ki so v študijah, nadzorovanih s placebom, sočasno prejemali karbamazepin in eslikarbazepinacetat, so o diplopiji, motnjah koordinacije in omotici poročali pogosteje.
English: Rare adverse reactions such as bone marrow depression, anaphylactic reactions, severe cutaneous reactions (e.g. Stevens-Johnson Syndrome), systemic lupus erythematosus or serious cardiac arrhythmias did not occur during the placebo-controlled studies of the epilepsy program with eslicarbazepine acetate.
Slovenian: Redki neželeni učinki, kot so depresija kostnega mozga, anafilaktične reakcije, hude kožne reakcije (npr. Stevens-Johnsonov sindrom), sistemski erimatozni lupus ali hude srčne aritmije, se med študijami, nadzorovanimi s placebom programa zdravljenja epilepsije z eslikarbazepinacetatom, niso pojavile.
English: Caution should be exercised in the treatment of patients with renal impairment and the dose should be adjusted according to creatinine clearance (CLCR) as follows: - CLCR >60 ml/min: no dose adjustment required - CLCR 30-60 ml/min: initial dose of 400 mg every other day for 2 weeks followed by a once daily dose of
Slovenian: Pri zdravljenju bolnikov z ledvično okvaro je potrebna previdnost, odmerek pa je treba prilagoditi glede na kreatininski očistek (CLCR) na naslednji način: -- CLCR > 60 ml/min: prilagajanje odmerka ni potrebno; -- CLCR 30-60 ml/min: začetni odmerek 400 mg vsak drugi dan 2 tedna, nato 400 mg vsak dan. Glede na odziv posameznika se odmerek lahko zveča; -- CLCR < 30 ml/min: pri bolnikih s hudo ledvično okvaro uporaba ni priporočljiva zaradi nezadostnih podatkov.
English: Furthermore, serum sodium levels should be determined if clinical signs of hyponatraemia occur.
Slovenian: Ravni natrija je treba preveriti tudi, če se pojavijo klinični znaki hiponatriemije.
English: Eslicarbazepine acetate was evaluated in rats and mice for potential adverse effects on fertility of the parental and F1 generation.
Slovenian: Eslikarbazepin acetat so preskušali pri podganah in miših, da bi ugotovili, ali ima možne neželene učinke na plodnost starševske in F1 generacije.
English: The percentage of subjects with a 50% reduction in seizure frequency over all phase III studies was 19% for placebo, 21% for eslicarbazepine acetate 400 mg, 34% for eslicarbazepine acetate 800 mg and 36% for eslicarbazepine acetate 1200 mg daily.
Slovenian: Odstotek bolnikov, pri katerih je prišlo do 50-odstotnega zmanjšanja pogostnosti epileptičnih napadov v vseh študijah III. faze, je 19 % za placebo, 21 % za eslikarbazepinacetat 400 mg, 34 % za eslikarbazepinacetat 800 mg in 36 % za eslikarbazepinacetat 1200 mg na dan.
English: Frequency of hyponatraemia increased with increasing eslicarbazepine acetate dose.
Slovenian: Pogostnost hiponatriemije se je z večanjem odmerka eslikarbazepinacetata povečala.
English: In vitro eslicarbazepine is a weak inducer of CYP3A4 and UDP-glucuronyl transferases.
Slovenian: Eslikarbazepin je in vitro šibek spodbujevalec encima CYP3A4 in UDP-glukuroniltransferaz.
English: Results from patient studies showed that concomitant treatment increased the risk of the following adverse reactions: diplopia (11.4% of subjects with concomitant carbamazepine, 2.4% of subjects without concomitant carbamazepine), abnormal coordination (6.7% with concomitant carbamazepine, 2.7% without concomitant carbamazepine), and dizziness (30.0% with concomitant carbamazepine, 11.5% without concomitant carbamazepine).
Slovenian: Izsledki kliničnih študij pri bolnikih kažejo, da sočasno zdravljenje zveča tveganje za naslednje neželene reakcije: diplopija (zabeleženo pri 11,4 % preskušancev, ki so sočasno jemali karbamazepin ter pri 2,4 % preskušancev, ki karbamazepina niso sočasno jemali), nenormalna koordinacija (pri 6,7 % preskušancev, ki so sočasno jemali karbamazepin ter pri 2,7 % preskušancev, ki karbamazepina niso sočasno jemali) in omotica (pri 30,0 % preskušancev, ki so sočasno jemali karbamazepin ter 11,5 % preskušancev, ki karbamazepina niso sočasno jemali).
English: In patients with pre-existing renal disease leading to hyponatraemia, or in patients concomitantly treated with medicinal products which may themselves lead to hyponatraemia (e.g. diuretics, desmopressin), serum sodium levels should be examined before and during treatment with eslicarbazepine acetate.
Slovenian: Pri bolnikih z obstoječo boleznijo ledvic, ki vodi v hiponatriemijo, ali pri bolnikih, ki sočasno prejemajo zdravila, ki lahko sama povzročajo hiponatriemijo (npr. diuretiki, dezmopresin), je treba pred zdravljenjem z eslikarbazepinacetatom in po njem preveriti ravni natrija.
English: The influence of Exalief on primary generalised seizures has not been studied.
Slovenian: Vpliva zdravila Exalief na primarne generalizirane epileptične napade niso raziskovali.
English: Oxcarbazepine and felbamate were not allowed as concomitant medicinal products in these studies.
Slovenian: Oksarbazepin in felbamat v teh študijah nista bila dovoljena kot sočasno zdravljenje.
English: If signs or symptoms of hypersensitivity develop, Exalief must be discontinued.
Slovenian: Če se pojavijo znaki ali simptomi preobčutljivosti, je treba zdravljenje z zdravilom Exalief prekiniti.
English: If at any time you have these thoughts, when taking Exalief, contact your doctor immediately.
Slovenian: Če boste kadarkoli med jemanjem zdravila Exalief imeli takšne misli, takoj obvestite zdravnika.
English: If clinically relevant hyponatraemia develops, Exalief should be discontinued.
Slovenian: Če se pojavi klinično pomembna hiponatriemija, je treba uporabo zdravila Exalief prekiniti.
English: As a risk to the breast-fed child cannot be excluded breastfeeding should be discontinued during treatment with Exalief.
Slovenian: Tveganja za dojenčka ni mogoče izključiti, zato je treba med zdravljenjem z zdravilom Exalief dojenje prekiniti.
English: Based on individual response, the dose of Exalief may need to be increased and the dose of phenytoin may need to be decreased.
Slovenian: Glede na odziv posameznika bo morda treba odmerek zdravila Exalief povečati in odmerek fenitoina zmanjšati.
English: BIAL - Portela & Cª , S.A. À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugal
Slovenian: BIAL - Portela & Cª , S.A. À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado Portugalska
English: Evidence of nephrotoxicity was observed in repeated dose toxicity studies in the rat, but was not seen in studies in mice or dogs, and is consistent with an exacerbation of spontaneous chronic progressive nephropathy in this species.
Slovenian: V študijah toksičnosti pri ponavljajočih se odmerkih pri podganah so opazili znake nefrotoksičnosti, vendar jih v študijah pri miših in psih niso opazili, kar je skladno s poslabšanjem spontane kronične progresivne nefropatije pri tej živalski vrsti.
English: • Neurological movement disorder where your muscles contract causing twisting and repetitive movements or abnormal postures.
Slovenian: • nevrološke motnje gibanja, pri katerih se mišice krčijo, kar povzroča zvijanje in ponavljajoče se gibe ali nenormalno držo.
English: • Sweating or having dry skin
Slovenian: • potenje ali suha koža,
English: The risk of increase of other specific adverse reactions caused by co-administration of carbamazepine and eslicarbazepine acetate cannot be excluded.
Slovenian: Tveganja za zvečanje pojavnosti drugih specifičnih neželenih učinkov zaradi sočasne uporabe karbamazepina in eslikarbazepinacetata ni mogoče izključiti.
English: As with other anti-epileptic medicinal products, if Exalief is to be discontinued it is recommended to withdraw it gradually to minimise the potential of increased seizure frequency.
Slovenian: Če je treba uporabo zdravila Exalief prekiniti, je kot pri drugih antiepileptikih to priporočljivo storiti postopoma, da se zmanjša možnost zvečane pogostnosti epileptičnih napadov.
English: Eslicarbazepine acetate 800 mg once daily and 1200 mg once daily were significantly more effective than placebo in reducing seizure frequency over a 12-week maintenance period.
Slovenian: Eslikarbazepinacetat pri odmerku 800 mg enkrat na dan in 1.200 mg enkrat na dan je bil bistveno učinkovitejši od placeba pri zmanjšanju pogostnosti epileptičnih napadov v 12-tedenskem vzdrževalnem obdobju.
English: Liver centrilobular hypertrophy was seen in repeated dose toxicity studies in mice and rats and an increased incidence of liver tumours was observed in the carcinogenicity study in mice; these findings are consistent with an induction of hepatic microsomal enzymes, an effect which has not been observed in patients receiving eslicarbazepine acetate.
Slovenian: V študijah toksičnosti ponavljajočih se odmerkov pri miših in podganah so opazili centrilobularno hipertrofijo jeter, v študijah kancerogenosti pri miših pa so opazili zvečano pogostnost jetrnih tumorjev; te ugotovitve so skladne z indukcijo mikrosomskih encimov v jetrih, kar je učinek, ki ga pri bolnikih, ki so prejemali eslikarbazepinacetat, niso opazili.
English: Exalief may be taken with or without food.
Slovenian: Način uporabe Zdravilo Exalief se lahko jemlje s hrano ali brez nje.
English: Exalief may make hormonal contraceptives such as the contraceptive pill less effective.
Slovenian: Hormonski kontraceptivi, kot so kontracepcijske tablete, so lahko zaradi zdravila Exalief manj učinkovita.
English: Hypertension, hypotension, orthostatic hypotension
Slovenian: Žilne bolezni hipertenzija, hipotenzija, ortostatska hipotenzija
English: If you forget to take Exalief
Slovenian: Če ste pozabili vzeti zdravilo Exalief
English: • Increased levels of circulating fats in your blood
Slovenian: • zvišane ravni maščob v krvnem obtoku,
English: Exalief has been given to you by your doctor to reduce your number of seizures.
Slovenian: Zdravilo Exalief vam je zdravnik predpisal za zmanjševanje števila epileptičnih napadov.
English: Exalief belongs to a group of medicines called anti-epileptics used to treat epilepsy, a condition where someone has repeated seizures or fits.
Slovenian: Zdravilo Exalief spada v skupino zdravil, imenovanih antiepileptiki, uporablja pa se za zdravljenje epilepsije, bolezni, pri kateri imajo bolniki ponavljajoče se epileptične napade.
English: Animal studies have shown excretion of eslicarbazepine in breast milk.
Slovenian: Študije na živalih so pokazale, da se eslikarbazepin izloča v mleko.
English: • Eye movement changes, fuzzy vision, red eye or eye pain
Slovenian: • spremembe premikanja oči, zamegljen vid, rdeče oči ali bolečine v očeh,
English: Eslicarbazepine acetate adversely interacts with oral contraceptives.
Slovenian: Eslikarbazepinacetat ima neželene interakcije s peroralnimi kontraceptivi.
English: Eslicarbazepine tmax is attained at 2 to 3 h post-dose.
Slovenian: Vrednost tmax eslikarbazepina se ponavadi doseže 2 do 3 ure po odmerku.
English: Symptoms include tremors, pain, cramping.
Slovenian: Simptomi vključujejo tresenje, bolečine in krče,
English: This is just in case any of them interfere with how Exalief works or how Exalief interferes with their effect.
Slovenian: To je samo previdnostni ukrep, če bi katerokoli od njih motilo delovanje zdravila Exalief ali če bi zdravilo Exalief vplivalo na njihov učinek.
English: An increase of the simvastatin dose may be required when used concomitantly with eslicarbazepine acetate.
Slovenian: Morda bo treba odmerek simvastatina povečati, kadar se ga uporablja sočasno z eslikarbazepinacetatom.
English: In studies with eslicarbazepine in fresh human hepatocytes a mild activation of UGT1A1 mediated glucuronidation was observed.
Slovenian: V študijah z eslikarbazepinom na svežih hepatocitih človeka so opazili blago aktivacijo glukuronidacije, pri kateri sodeluje UGT1A1.
English: Hypersensitivity to the active substance, to other carboxamide derivatives (e.g. carbamazepine, oxcarbazepine) or to any of the excipients.
Slovenian: Preobčutljivost za zdravilno učinkovino, druge derivate karboksamida (npr. karbamazepin, okskarbazepin) ali katerokoli pomožno snov.
English: Caution should be exercised in the treatment of patients with renal impairment and the dose should be adjusted according to creatinine clearance (see section 4.2).
Slovenian: Pri zdravljenju bolnikov z ledvično okvaro je potrebna previdnost, odmerek pa je treba prilagoditi glede na kreatininski očistek (glejte poglavje 4.2).
English: Glucuronidation is the major metabolic pathway for both eslicarbazepine and lamotrigine and therefore an interaction could be expected.
Slovenian: Glavna presnovna pot eslikarbazepina in lamotrigina je glukuronidacija, zato bi lahko pričakovali interakcije.
English: Depending on how you respond to Exalief, your dose may be increased to 1200 mg once daily.
Slovenian: Glede na vaš odziv na zdravilo Exalief vam zdravnik lahko odmerek zveča na 1.200 mg enkrat na dan.
English: It is unknown whether eslicarbazepine acetate is excreted in human breast milk.
Slovenian: Ni znano, ali se eslikarbazepinacetat izloča v materino mleko.
English: Eslicarbazepine acetate does not affect its own metabolism or clearance.
Slovenian: Eslikarbazepinacetat ne vpliva na lastno presnovo ali na svoj očistek.
English: There is no experience regarding the withdrawal of concomitant use of anti-epileptic medicinal products during treatment with Exalief (switch to monotherapy).
Slovenian: Izkušenj z odtegnitvijo antiepileptikov, ki se uporabljajo sočasno z zdravilom Exalief (prehod na samostojno zdravljenje), ni.
English: • Numbness and tingling in hands and feet
Slovenian: • otrplost in mravljinčenje v dlaneh in stopalih.
English: What Exalief looks like and contents of the pack
Slovenian: Izgled zdravila Exalief in vsebina pakiranja
English: • Weight loss or extreme weight gain
Slovenian: • izguba ali izjemno povečanje telesne mase,
English: In humans, the pharmacological activity of eslicarbazepine acetate is primarily exerted through the active metabolite eslicarbazepine.
Slovenian: Pri človeku se farmakološka aktivnost eslikarbazepinacetata kaže predvsem skozi aktivni presnovek eslikarbazepin.
English: Do not use Exalief after the expiry date, which is stated on the blister package, bottle and the carton after EXP.
Slovenian: Zdravila Exalief ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu, steklenici in škatli poleg oznake »EXP«.
English: In a fertility study in mice, developmental effects were observed in embryos; however, effects could also result from lower corpora lutea count and thus show impairment of fertility.
Slovenian: V študiji plodnosti pri miših so se pokazali učinki na razvoj ploda, vendar pa bi bili učinki lahko tudi posledica zmanjšanja števila rumenih telesc (corpus luteum) in tako posledično zmanjšanje plodnosti.
English: The tablets are packaged in blisters in cardboard boxes containing 7, 14 or 28 tablets.
Slovenian: Tablete so pakirane v pretisne omote v kartonskih škatlah, ki vsebujejo 7, 14 ali 28 tablet.
English: PVC/ALU blister
Slovenian: Pretisni omot iz PVC/ALU
English: See ‘Taking other medicines' section for advice about contraception.
Slovenian: Nasveti glede kontracepcije so v poglavju »Jemanje drugih zdravil«.
English: Drug toxicity, fall, joint and procedural complications injury, poisoning, skin
Slovenian: Poškodbe in zastrupitve in zapleti pri posegih toksičnost zdravila, padci, poškodbe sklepov, zastrupitev, poškodbe kože
English: • Mood changes or hallucinations
Slovenian: • spremembe razpoloženja ali blodnje,
English: Eslicarbazepine acetate metabolites can effectively be cleared by haemodialysis, if necessary (see section 5.2).
Slovenian: Če je nujno, se lahko presnovki eslikarbazepinacetata učinkovito odstranijo s hemodializo (glejte poglavje 5.2).
English: Moderate hepatic impairment did not affect the pharmacokinetics of eslicarbazepine acetate.
Slovenian: Zmerna jetrna okvara ni vplivala na farmakokinetiko eslikarbazepinacetata.
English: As clinical data are limited in patients with mild to moderate hepatic impairment and pharmacokinetic and clinical data are missing in patients with severe hepatic impairment, Exalief should be used with caution in patients with mild to moderate hepatic impairment and is not recommended in patients with severe hepatic impairment.
Slovenian: Pri bolnikih z blago do zmerno jetrno okvaro so klinični podatki omejeni, pri bolnikih s hudo jetrno okvaro pa farmakokinetičnih in kliničnih podatkov ni, zato je treba pri bolnikih z blago do zmerno jetrno okvaro zdravilo Exalief uporabljati previdno, pri bolnikih s hudo jetrno okvaro pa njegova uporaba ni priporočena.
English: Blood pressure decreased, weight decreased, blood pressure diastolic decreased, blood pressure increased, blood pressure systolic decreased, blood sodium decreased, haematocrit decreased, haemoglobin decreased, heart rate increased, transaminases increased, triglycerides increased, triiodothyronine (T3) free decreased, thyroxine (T4) free decreased
Slovenian: Preiskave znižan krvni tlak, zmanjšana telesna masa, znižan diastolični krvni tlak, zvišan krvni tlak, znižan sistolični krvni tlak, znižan natrij v krvi, znižan hematokrit, znižan hemoglobin, povečan srčni utrip, zvišane transaminaze, zvišani trigliceridi, znižan prosti trijodotironin (T3), znižan prosti tiroksin (T4)
English: • Irritability
Slovenian: • razdražljivost,
English: Based on individual response, the dose of Exalief may need to be increased if used concomitantly with carbamazepine.
Slovenian: Glede na odziv posameznega bolnika bo morda treba odmerek zdravila Exalief povečati, kadar se ga uporablja sočasno z karbamazepinom.