FrancophonIA/ELRC3.0 huggingface dataset:
English: • you have type 1 diabetes - a condition where your body does not produce any insulin
Croatian: Ovaj lijek nije inzulin i stoga se ne smije koristiti ako: • imate šećernu bolest tipa 1 - bolest kod koje vaše tijelo ne proizvodi inzulin
English: Start by checking your pen to make sure that it contains Ozempic 0.5 mg, then look at the illustrations below to get to know the different parts of your pen and needle.
Croatian: Započnite tako što ćete provjeriti Vašu brizgalicu kako biste bili sigurni da sadrži Ozempic 0,5 mg, zatim pogledajte ilustracije u nastavku da se upoznate s različitim dijelovima Vaše brizgalice i igle.
English: Always use the dose counter and the dose pointer to see that 1 mg has been selected before injecting this medicine.
Croatian: Uvijek koristite brojčanik doze i pokazivač doze kako biste provjerili da li ste odabrali 1 mg prije injiciranja ovog lijeka.
English: Table 2 SUSTAIN 1: Results at week 30
Croatian: Tablica 2 SUSTAIN 1: Rezultati u 30. tjednu
English: 0.5 mg selected
Croatian: odabrano 0,5 mg
English: Keep turning until the dose counter stops and shows 0.25 mg.
Croatian: Okrećite izbornik doze sve dok se brojčanik doze ne zaustavi i pokaže 0,25 mg.
English: Only the dose counter and dose pointer will show that 1 mg has been selected.
Croatian: Samo pomoću brojčanika doze i pokazivača doze možete vidjeti da ste odabrali 1 mg.
English: Table 5 SUSTAIN 3: Results at week 56
Croatian: Tablica 5 SUSTAIN 3: Rezultati u 56. tjednu
English: Table 6 SUSTAIN 4: Results at week 30
Croatian: Tablica 6 SUSTAIN 4: Rezultati u 30. tjednu
English: During hypoglycaemia, semaglutide diminishes insulin secretion and does not impair glucagon secretion.
Croatian: Tijekom hipoglikemije semaglutid smanjuje lučenje inzulina, ali ne remeti lučenje glukagona.
English: Insulin Glargine
Croatian: Glargin inzulin
English: Keep turning until the dose counter stops and shows 0.5 mg.
Croatian: Okrećite izbornik doze sve dok se brojčanik doze ne zaustavi i pokaže 0,5 mg.
English: Table 7 SUSTAIN 5: Results at week 30
Croatian: Tablica 7 SUSTAIN 5: Rezultati u 30. tjednu
English: Favours placebo
Croatian: U korist placeba
English: -3.6c [-4.3, -2.8]a p <0.0001 (2-sided) for superiority b
Croatian: -3,6c [-4,3; -2,8]a p <0,0001 (dvostrano) za superiornost b
English: This reduces the risk of blocked needles, contamination, infection, leakage of solution and inaccurate dosing.
Croatian: Tako se smanjuje rizik od začepljenja igala, onečišćenja, infekcije, istjecanja otopine i neispravnog doziranja.
English: Ozempic 0.25 mg solution for injection is available in the following pack size: 1 pen and 4 disposable NovoFine Plus needles.
Croatian: Ozempic 0,25 mg otopina za injekciju dostupna je u sljedećim veličinama pakiranja: 1 brizgalica i 4 jednokratne igle NovoFine Plus
English: Semaglutide lowers the fasting and postprandial glucagon concentrations.
Croatian: Semaglutid snižava koncentracije glukoze natašte i postprandijalne glukoze.
English: If there is not enough solution left in your pen for a full dose, do not use it. Use a new Ozempic pen.
Croatian: Ako nema dovoljno preostale otopine u brizgalici za punu dozu, ne upotrebljavajte je.
English: -4.2 [-4.9, -3.5]a ap <0.0001 (2-sided) for superiority
Croatian: -4,2 [-4,9; -3,5]a ap <0,0001 (dvostrano) za superiornost
English: Patients (%) achieving HbA1c <7% 68 FPG (mmol/L)
Croatian: Bolesnici (%) koji su postigli HbA1c <7% 74 Glukoza u plazmi natašte (mmol/l)
English: Combination with premix insulin ± 1-2 OADs
Croatian: Kombinacija s predmiješanim inzulinom ± 1-2 oralna antidijabetika
English: The dose selector clicks differently when turned forwards, backwards or past 1 mg. Do not count the pen clicks.
Croatian: Izbornik doze drugačije „klikne“ kad se okreće unaprijed, unazad ili preko 1 mg.
English: Caution should be exercised in patients with a history of pancreatitis.
Croatian: Oprez je nužan u bolesnika koji u anamnezi imaju pankreatitis.
English: Ozempic 0.5 mg (46% and 13%) and 1 mg (52 - 62% and 21 - 24%) compared with the active comparators sitagliptin (18% and 3%) and exenatide ER (17% and 4%).
Croatian: Nakon godinu dana liječenja, smanjenje težine od ≥5% i ≥10% postiglo je više ispitanika koji su primali Ozempic 0,5 mg (46% i 13%) i 1 mg (52-62% i 21-24%) u usporedbi s aktivnim lijekovima za usporedbu sitagliptinom (18% i 3%) i eksenatidom ER (17% i 4%).
English: You may get side effects such as feeling sick (nausea).
Croatian: Mogu se pojaviti nuspojave kao što je mučnina.
English: Ozempic 0.25 mg solution for injection
Croatian: Ozempic 0,25 mg otopina za injekciju
English: Each pen contains 3 ml solution, delivering 4 doses of 1 mg.
Croatian: Jedna brizgalica sadrži 3 ml otopine, za primjenu 4 doze od 1 mg.
English: Table 3 SUSTAIN 2: Results at week 56
Croatian: Tablica 3 SUSTAIN 2: Rezultati u 56. tjednu
English: Always use the dose counter and the dose pointer to see that 0.25 mg has been selected before injecting this medicine.
Croatian: Uvijek koristite brojčanik doze i pokazivač doze kako biste provjerili da li ste odabrali 0,25 mg prije injiciranja ovog lijeka.
English: Flow check symbol selected
Croatian: Odabran je simbol za provjeru protoka
English: At week 30, the change in HbA1c was -1.6%, -1.5% and 0.1% for Ozempic 0.5 mg, Ozempic 1 mg, and placebo, respectively.
Croatian: U 30. tjednu promjena vrijednosti HbA1c bila je -1,6% za Ozempic 0,5 mg, -1,5% za Ozempic 1 mg i 0,1% za placebo.
English: Always dispose of the needle after each injection to ensure convenient injections and prevent blocked needles.
Croatian: Nakon svakog injiciranja uvijek odložite iglu u otpad kako biste bili sigurni da će injiciranje biti odgovarajuće i kako biste spriječili začepljenje igala.
English: Always use the dose counter and the dose pointer to see that 0.5 mg has been selected before injecting this medicine.
Croatian: Uvijek koristite brojčanik doze i pokazivač doze kako biste provjerili da li ste odabrali 0,5 mg prije injiciranja ovog lijeka.
English: MARKETING AUTHORISATION NUMBERS EU/1/17/1251/003 1 pen and 4 disposable needles EU/1/17/1251/004 3 pens and 12 disposable needles
Croatian: 12. BROJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/17/1251/003 1 brizgalica i 4 jednokratne igle EU/1/17/1251/004 3 brizgalice i 12 jednokratnih igala
English: MARKETING AUTHORISATION NUMBERS EU/1/17/1251/005 1 pen and 4 disposable needles EU/1/17/1251/006 3 pens and 12 disposable needles
Croatian: 12. BROJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/17/1251/005 1 brizgalica i 4 jednokratne igle EU/1/17/1251/006 3 brizgalice i 12 jednokratnih igala
English: How to store Ozempic
Croatian: Kako čuvati Ozempic
English: INFORMATION IN BRAILLE Ozempic 0.5 mg
Croatian: 16. PODACI NA BRAILLEOVOM PISMU Ozempic 0,5 mg
English: • Press and hold down the dose button until the dose counter shows 0.
Croatian: • Pritisnite gumb za doziranje i držite ga pritisnutim sve dok se na brojčaniku doze ne prikaže 0.
English: STATEMENT OF ACTIVE SUBSTANCE Each dose (0.74 ml) contains 1 mg semaglutide (1.34 mg/ml),
Croatian: NAVOĐENJE DJELATNE TVARI Jedna doza (0,74 ml ) sadrži 1 mg semaglutida (1,34 mg/ml).
English: HbA1c at baseline was 8.8%, 8.9% and 8.9% for Ozempic 0.5 mg, Ozempic 1 mg, and placebo, respectively.
Croatian: HbA1c je na početku bio 8,8% za Ozempic 0,5 mg, 8,9% za Ozempic 1 mg i 8,9% za placebo.
English: Semaglutide delays the rate of gastric emptying as assessed by paracetamol pharmacokinetics during a standardised meal test. Paracetamol AUC0-60min and Cmax were decreased by 27% and 23%, respectively, following concomitant use of semaglutide 1 mg.
Croatian: Nakon istodobne primjene semaglutida od 1 mg, AUC0-60min paracetamola smanjio se za 27%, a Cmax za 23%.
English: -5.1 [-6.1, -4.0]a p <0.0001 (2-sided) for superiority
Croatian: -5,1 [-6,1; -4,0]a p <0,0001 (dvostrano) za superiornost
English: PHARMACEUTICAL PARTICULARS 6.1 List of excipients Disodium phosphate dihydrate Propylene glycol
Croatian: FARMACEUTSKI PODACI 6.1 Popis pomoćnih tvari natrijev hidrogenfosfat dihidrat propilenglikol fenol kloridna kiselina (za podešavanje pH) natrijev hidroksid (za podešavanje pH)
English: Each pen contains 1.5 ml of solution, delivering 4 doses of 0.25 mg.
Croatian: Jedna brizgalica sadrži 1,5 ml otopine za primjenu 4 doze od 0,25 mg.
English: Hypoglycaemiaa when used with other OADs
Croatian: Hipoglikemijaa kod primjene s drugim oralnim antidijabeticima
English: Ozempic 0.5 mg vs dulaglutide 0.75 mg c Ozempic 1 mg vs dulaglutide 1.5 mg
Croatian: Ozempic 0,5 mg naspram dulaglutid 0,75 mg c
English: Each pen contains 1.5 ml of solution, delivering 4 doses of 0.5 mg.
Croatian: Jedna brizgalica sadrži 1,5 ml otopine, za primjenu 4 doze od 0,5 mg.
English: One pre-filled pen contains 4 mg semaglutide* in 3.0 ml solution.
Croatian: Jedna napunjena brizgalica sadrži 4 mg semaglutida* u 3,0 ml otopine.
English: The dose selector clicks differently when turned forwards, backwards or past 0.25 mg. Do not count the pen clicks.
Croatian: Izbornik doze drugačije „klikne“ kad se okreće unaprijed, unazad ili preko 0,25 mg.
English: Do not freeze Ozempic and do not use it if it has been frozen.
Croatian: Ozempic niti ga primjenjivati ako je bio zamrznut.
English: The dose selector clicks differently when turned forwards, backwards or past 0.5 mg. Do not count the pen clicks.
Croatian: Izbornik doze drugačije „klikne“ kad se okreće unaprijed, unazad ili preko 0,5 mg.
English: At week 30, the change in HbA1c was -1.3%, -1.8% and0.4% for Ozempic 0.5 mg, Ozempic 1 mg, and placebo, respectively.
Croatian: U 30. tjednu promjena HbA1c bila je -1,3% za Ozempic 0,5 mg, -1,8% za Ozempic 1 mg i -0,4% za placebo.
English: The mean volume of distribution of semaglutide following subcutaneous administration in patients with type 2 diabetes was approximately 12.5 L. Semaglutide was extensively bound to plasma albumin
Croatian: Srednji volumen distribucije semaglutida nakon potkožne primjene u bolesnika sa šećernom bolešću tipa 2 bio je približno 12,5 l.
English: How to use Ozempic
Croatian: Kako primjenjivati Ozempic
English: Intent-to-Treat (ITT) Population (N) HbA1c (%) Baseline (mean) Change from baseline at week 56 Difference from exenatide [95% CI] -0.6 [-0.8, -0.4]a Patients (%) achieving HbA1c <7% FPG (mmol/L) Baseline (mean) Change from baseline at week 56 Body weight (kg) Baseline (mean) Change from baseline at week 56 Difference from exenatide [95% CI] -3.8 [-4.6, -3.0]a ap <0.0001 (2-sided) for superiority
Croatian: Bolesnici (%) koji su postigli HbA1c <7% Glukoza u plazmi natašte (mmol/l) Početna vrijednost (srednja) Promjena od početne vrijednosti u 30. tjednu Tjelesna težina (kg) Početna vrijednost (srednja) Promjena od početne vrijednosti u 30. tjednu Razlika u odnosu na glargin inzulin [95% CI] -4,6 [-5,3; -4,0]a -6,34 [-7,0; -5,7]a p <0,0001 (dvostrano) za superiornost
English: One pre-filled pen contains 4 mg semaglutide in 3 ml solution.
Croatian: Jedna napunjena brizgalica sadrži 4 mg semaglutida u 3 ml otopine.
English: Only the dose counter and dose pointer will show that 0.5 mg has been selected.
Croatian: Samo pomoću brojčanika doze i pokazivača doze možete vidjeti da ste odabrali 0,5 mg.
English: Only the dose counter and dose pointer will show that 0.25 mg has been selected.
Croatian: Samo pomoću brojčanika doze i pokazivača doze možete vidjeti da ste odabrali 0,25 mg.
English: One pre-filled pen contains 2 mg semaglutide in 1.5 ml solution.
Croatian: Jedna napunjena brizgalica sadrži 2 mg semaglutida u 1,5 ml otopine.
English: One pre-filled pen contains 2 mg semaglutide* in 1.5 ml solution.
Croatian: Jedna napunjena brizgalica sadrži 2 mg semaglutida* u 1,5 ml otopine.
English: STATEMENT OF ACTIVE SUBSTANCE Each dose (0.19 ml) contains 0.25 mg semaglutide (1.34 mg/ml),
Croatian: NAVOĐENJE DJELATNE TVARI Jedna doza (0,19 ml ) sadrži 0,25 mg semaglutida (1,34 mg/ml).
English: STATEMENT OF ACTIVE SUBSTANCE Each dose (0.37 ml) contains 0.5 mg semaglutide (1.34 mg/ml),
Croatian: NAVOĐENJE DJELATNE TVARI Jedna doza (0,37 ml ) sadrži 0,5 mg semaglutida (1,34 mg/ml).
English: Ozempic 0.5 mg solution for injection
Croatian: Ozempic 0,5 mg otopina za injekciju
English: Diabetic retinopathy complications
Croatian: Komplikacije dijabetičke retinopatije
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE OF ADMINISTRATION Ozempic 1 mg injection semaglutide subcutaneous use
Croatian: NAZIV LIJEKA I PUT PRIMJENE LIJEKA Ozempic 1 mg injekcija semaglutid
English: Each dose contains 1 mg of semaglutide in 0.74 ml.
Croatian: Jedna doza sadrži 1 mg semaglutida u 0,74 ml.
English: • gall stones
Croatian: • žučni kamenci
English: Please read these instructions carefully before using your Ozempic pre-filled pen.
Croatian: Prije uporabe Ozempic napunjene brizgalice pažljivo pročitajte ove upute.
English: Ozempic 1 mg solution for injection in pre-filled pen semaglutide
Croatian: Ozempic 1 mg otopina za injekciju u napunjenoj brizgalici semaglutid
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE OF ADMINISTRATION Ozempic 0.25 mg injection semaglutide subcutaneous use
Croatian: NAZIV LIJEKA I PUT PRIMJENE LIJEKA Ozempic 0,25 mg injekcija semaglutid
English: Ozempic N (%)
Croatian: N (%)
English: HbA1c at baseline was 8.2%, 8.4% and 8.4% for Ozempic 0.5 mg, Ozempic 1 mg, and placebo, respectively.
Croatian: Vrijednosti HbA1c su na početku bile 8,2% za Ozempic 0,5 mg, 8,4% za Ozempic 1 mg i 8,4% za placebo.
English: SUSTAIN 5 - Ozempic vs. placebo both in combination with basal insulin In a 30-week double-blind placebo-controlled trial, 397 patients inadequately controlled with basal insulin with or without metformin were randomised to Ozempic 0.5 mg once weekly, Ozempic 1 mg once weekly or placebo.
Croatian: U 30-tjednom dvostruko slijepom placebom kontroliranom ispitivanju, 397 bolesnika koji nisu odgovarajuće kontrolirani bazalnim inzulinom s metforminom ili bez njega randomizirano je na Ozempic 0,5 mg jedanput na tjedan ili Ozempic 1 mg jedanput na tjedan ili placebo.
English: • indigestion
Croatian: • umor
English: Each dose contains 0.5 mg of semaglutide in 0.37 ml.
Croatian: Jedna doza sadrži 0,5 mg semaglutida u 0,37 ml.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE OF ADMINISTRATION Ozempic 0.5 mg injection semaglutide subcutaneous use
Croatian: NAZIV LIJEKA I PUT PRIMJENE LIJEKA Ozempic 0,5 mg injekcija semaglutid
English: Change from baseline at week 30 Difference from placebo [95% CI]
Croatian: Razlika u odnosu na placebo [95% CI]
English: Glucagon secretion
Croatian: Izlučivanje glukagona
English: Ozempic 0.25 mg solution for injection in pre-filled pen semaglutide
Croatian: Ozempic 0,25 mg otopina za injekciju u napunjenoj brizgalici semaglutid
English: Instructions on how to use Ozempic 0.5 mg solution for injection in pre-filled pen
Croatian: Upute za uporabu lijeka Ozempic 0,5 mg otopina za injekciju u napunjenoj brizgalici
English: Each dose contains 0.25 mg of semaglutide in 0.19 ml.
Croatian: Jedna doza sadrži 0,25 mg semaglutida u 0,19 ml.
English: Intent-to-Treat (ITT) Population (N) HbA1c (%)
Croatian: Bolesnici (%) koji su postigli HbA1c <7%
English: Semaglutide lowered high blood glucose concentrations by stimulating insulin secretion and lowering glucagon secretion in a glucose dependent manner.
Croatian: Lučenje inzulina i glukagona u ovisnosti od glukoze Semaglutid snižava visoke koncentracije glukoze u krvi poticanjem lučenja inzulina i snižavanjem lučenja glukagona u ovisnosti od glukoze.
English: Time since randomisation (week) Ozempic 0.5 mg Sitagliptin
Croatian: Ozempic 0,5 mg Sitagliptin
English: Instructions on how to use Ozempic 0.25 mg solution for injection in pre-filled pen
Croatian: Upute za uporabu lijeka Ozempic 0,25 mg otopina za injekciju u napunjenoj brizgalici Prije uporabe
English: Ozempic 0.5 mg solution for injection in pre-filled pen semaglutide
Croatian: Ozempic 0,5 mg otopina za injekciju u napunjenoj brizgalici semaglutid
English: Count slowly:
Croatian: Polako brojite:
English: Difference from insulin glargine [95% CI] -4.6 [-5.3, -4.0]
Croatian: Razlika u odnosu na eksenatid [95% CI] -3,8 [-4,6, -3,0]a p <0,0001 (dvostrano) za superiornost
English: Similar exposure was achieved with subcutaneous administration of semaglutide in the abdomen, thigh, or upper arm. Absolute bioavailability of subcutaneous semaglutide was 89%.
Croatian: Apsolutna bioraspoloživost supkutanog semaglutida bila je 89%.
English: Talk to your doctor if you have any questions or concerns.
Croatian: U slučaju bilo kakvih pitanja ili nedoumica obratite se svom liječniku.
English: Ozempic 1 mg solution for injection is available in the following pack sizes: 1 pen and 4 disposable NovoFine Plus needles.
Croatian: Ozempic 1 mg otopina za injekciju dostupna je u sljedećim veličinama pakiranja: 1 brizgalica i 4 jednokratne igle NovoFine Plus 3 brizgalice i 12 jednokratnih igala NovoFine Plus
English: Ozempic 0.25 mg solution for injection: Each pre-filled pen contains 1.5 ml of solution, delivering 4 doses of 0.25 mg.
Croatian: Ozempic 0,25 mg otopina za injekciju: Jedna napunjena brizgalica sadrži 1,5 ml otopine, za primjenu
English: Favours Ozempic
Croatian: Ozempic
English: Diabetic eye disease (retinopathy)
Croatian: Dijabetička retinopatija
English: 3 ml (4 doses)
Croatian: (4 doze)
English: Ozempic 0.5 mg solution for injection is available in the following pack sizes: 1 pen and 4 disposable NovoFine Plus needles.
Croatian: Ozempic 0,5 mg otopina za injekciju dostupna je u sljedećim veličinama pakiranja: 1 brizgalica i 4 jednokratne igle NovoFine Plus 3 brizgalice i 12 jednokratnih igala NovoFine Plus
English: -2.3b [-3.0, -1.5]a
Croatian: -2,3 [-3,1; -1,6]a
English: The total paracetamol exposure
Croatian: Nije bilo utjecaja na ukupnu izloženost paracetamolu (AUC0-5h).
English: Difference from sitagliptin [95% CI] -2.3 [-3.1, -1.6]a
Croatian: Razlika u odnosu na placebo [95% CI] -2,7 [-3,9; -1,6]a -3,6 [-4,7; -2,4]a ap <0,0001 (dvostrano) za superiornost
English: Your pen is a pre-filled dial-a-dose pen.
Croatian: Vaša brizgalica je napunjena brizgalica s mogućnošću odabira doze.
English: Elderly
Croatian: Omaglica
English: -0.4b [-0.6, -0.2]a
Croatian: [-0,6; -0,2]a
English: Change from baseline at week 30 Body weight (kg)
Croatian: Tjelesna težina (kg) Početna vrijednost (srednja) Promjena od početne vrijednosti u 40. tjednu
English: No episodes of severe hypoglycaemia were observed when semaglutide was used as monotherapy.
Croatian: Kada se semaglutid koristio u monoterapiji nisu zapažene epizode teške hipoglikemije.
English: Phenol
Croatian: Proljev
English: Nausea Diarrhoea
Croatian: Pražnjenje želuca
English: Change from baseline at week 40
Croatian: Početna vrijednost (srednja) Promjena od početne vrijednosti u 40. tjednu
English: Further information on NeuroBloc can be found on the Agency's website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Croatian: Više informacija o lijeku NeuroBloc možete naći na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: The dose and number of injections depend on the patient's response.
Croatian: Doza i broj injekcija ovise o reakciji bolesnika.
English: This overview was last updated in 06-2018.
Croatian: Ovaj pregled informacija posljednji je put ažuriran: 6. 2018.
English: Most patients who had a response to NeuroBloc by the fourth week had returned to their original condition 12 to 16 weeks after the injection.
Croatian: Većina bolesnika koja je reagirala na lijek NeuroBloc do četvrtog tjedna vratila se u prvotno stanje 12 do 16 tjedana nakon primanja injekcije.
English: NeuroBloc (botulinum toxin type B) EMA/356522/2018
Croatian: NeuroBloc (botulinski toksin tipa B) EMA/356522/2018
English: Other information about NeuroBloc
Croatian: Ostale informacije o lijeku NeuroBloc
English: What measures are being taken to ensure the safe and effective use of NeuroBloc?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka NeuroBloc?
English: The effect of an injection of NeuroBloc gradually wears off over time.
Croatian: Učinak injekcije lijeka NeuroBloc postupno se smanjuje tijekom vremena.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of NeuroBloc have been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka NeuroBloc nalaze se u sažetku opisa svojstava lijeka i u uputi o lijeku.
English: For more information about using NeuroBloc, see the package leaflet or contact your doctor or pharmacist.
Croatian: Za više informacija o primjeni lijeka NeuroBloc vidjeti uputu o lijeku ili se obratite liječniku ili ljekarniku.
English: The toxin is the cause of a type of food poisoning called botulism, where patients suffer from muscle weakness and paralysis.
Croatian: Toksin uzrokuje vrstu otrovanja hranom koje se naziva botulizam, kod kojeg bolesnici pate od slabosti mišića i paralize.
English: The toxin reduces the release of acetylcholine from the nerve endings.
Croatian: Toksin smanjuje otpuštanje acetilkolina iz živčanih završetaka.
English: Side effects reported with NeuroBloc are carefully evaluated and any necessary action taken to protect patients.
Croatian: Nuspojave prijavljene za lijek NeuroBloc pažljivo se procjenjuju i poduzimaju se potrebne mjere za zaštitu bolesnika.
English: What is NeuroBloc and what is it used for?
Croatian: Što je NeuroBloc i za što se koristi?
English: NeuroBloc was more effective than placebo (a dummy treatment) at improving symptoms of cervical dystonia in four studies involving a total of 392 adults.
Croatian: Lijek NeuroBloc bio je djelotvorniji nego placebo (prividno liječenje) u poboljšanju simptoma cervikalne distonije u četirima ispitivanjima koja su obuhvaćala ukupno 392 odrasle osobe.
English: NeuroBloc is available as a solution for injection (5,000 units [U] per millilitre) and it can only be obtained with a prescription.
Croatian: NeuroBloc je dostupan je kao otopina za injekciju (5 000 jedinica [U] po mililitru), a izdaje se samo na liječnički recept.
English: NeuroBloc treatment starts with 10,000 U, divided into equal doses and injected directly into the two to four muscles in the neck and shoulders that are most affected.
Croatian: Liječenje lijekom NeuroBloc započinje s 10 000 jedinica podijeljenih u jednake doze koje se ubrizgavaju izravno u dva do četiri najzahvaćenija mišića u vratu i ramenima.
English: Cervical dystonia, which is also known as torticollis, is a disorder when the neck muscles contract, causing abnormal movement and twisting of the neck and unusual positioning of the head.
Croatian: Cervikalna distonija, koja je također poznata pod nazivom tortikolis, poremećaj je kod kojeg dolazi do stezanja (kontrakcije) mišića vrata, koje uzrokuje abnormalno pomicanje i okretanje vrata i neuobičajene položaje glave.
English: Effectiveness was measured by looking at the change in symptoms (severity, pain and disability) after four weeks, measured using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS).
Croatian: Djelotvornost se mjerila promatranjem promjena u simptomima (njihovoj težini, boli i invaliditetu) nakon četiri tjedna, što je mjereno s pomoću ljestvice za procjenu spazmodičnog tortikolisa (engl.
English: Why is NeuroBloc authorised in the EU?
Croatian: Zašto je lijek NeuroBloc odobren u EU-u?
English: NeuroBloc received a marketing authorisation valid throughout the EU on 22 January 2001.
Croatian: Lijek NeuroBloc dobio je odobrenje za stavljanje u promet koje je na snazi u Europskoj uniji od 22. siječnja 2001.
English: It is only used in hospitals, by a doctor who has experience in the treatment of cervical dystonia and in the use of botulinum toxins.
Croatian: Upotrebljava se samo u bolnicama i primjenjuje ga liječnik s iskustvom u liječenju cervikalne distonije i primjeni botulinskih toksina.