FrancophonIA/ELRC3.0 huggingface dataset:
English: Duration of response by investigatord
Croatian: Trajanje odgovora prema ispitivaču
English: Talazoparib is an inhibitor of PARP enzymes, PARP1, and PARP2.
Croatian: Talazoparib je inhibitor PARP enzima, PARP1 i PARP2.
English: Patients should be treated until disease progression or unacceptable toxicity occurs.
Croatian: Bolesnike je potrebno liječiti do progresije bolesti ili pojave neprihvatljive toksičnosti.
English: Ciclosporin - used in organ transplantation to prevent rejection.
Croatian: - Ciklosporin - koristi se kod transplantacije organa kako bi se spriječilo odbacivanje.
English: Pharmacotherapeutic group: other antineoplastic agents, ATC code: L01XX60
Croatian: Farmakoterapijska skupina: ostali antineoplastici, ATK oznaka: L01XX60
English: If such events occur, dose modifications (reduction or interruption) are recommended (see section 4.2).
Croatian: Ako se pojave takvi događaji, preporučuju se promjene doze (smanjenje ili privremeni prekid) (vidjeti dio 4.2).
English: The secondary objectives were objective response rate (ORR), overall survival (OS), safety, and PK.
Croatian: Sekundarni ciljevi bili su stopa objektivnog odgovora (ORR), ukupno preživljenje (OS), sigurnost i farmakokinetika.
English: However, based on urinary excretion data the absolute bioavailability is at least 41% with fraction absorbed of at least 69% (see Elimination).
Croatian: Međutim, na temelju podataka izlučivanja u urinu apsolutna bioraspoloživost iznosi najmanje 41 % dok apsorbirana frakcija iznosi najmanje 69 % (vidjeti dio „Eliminacija“).
English: Studies in animals have shown embryo-foetal toxicity (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su embrio-fetalnu toksičnost (vidjeti dio 5.3).
English: Renal elimination of unchanged drug (passive filtration and active secretion) is the major route of talazoparib elimination.
Croatian: Bubrežna eliminacija nepromijenjenog lijeka (pasivna filtracija i aktivna sekrecija) je glavni put eliminacije talazopariba.
English: Children and adolescents Talzenna is not to be used in children or adolescents (under 18 years of age).
Croatian: Talzenna se ne smije koristiti u djece ili adolescenata (mlađih od 18 godina).
English: No metabolites that individually represented more than 10% of the administered dose were recovered in the urine or faeces.
Croatian: Nijedan od metabolita koji su zasebno predstavljali više od 10 % primijenjene doze nije bio pronađen u urinu ili stolici.
English: Do not take a double dose to make up for the forgotten or vomited capsules.
Croatian: Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljene kapsule ili kapsule koje ste povratili.
English: No prior treatment with a PARP inhibitor was permitted.
Croatian: Nije bilo dozvoljeno prethodno liječenje inhibitorom PARP-a.
English: f. Stratified CMH test.
Croatian: Stratificirani CMH test.
English: Low blood cell counts
Croatian: Nizak broj krvnih stanica
English: If MDS/AML is confirmed, talazoparib should be discontinued.
Croatian: Ako je potvrđen MDS/AML, treba prekinuti primjenu talazopariba.
English: What Talzenna is and how it works
Croatian: Što je Talzenna i kako djeluje
English: Abbreviations: n=number of patients; N/A=not applicable.
Croatian: Kratice: n=broj bolesnika; N/P=nije primjenjivo.
English: What you need to know before you take Talzenna 3.
Croatian: Što morate znati prije nego počnete uzimati lijek Talzenna 3.
English: The results have shown that age, sex, and body weight had no clinically relevant effect on the PK of talazoparib.
Croatian: Rezultati su pokazali da dob, spol i tjelesna težina nisu imali klinički značajan učinak na farmakokinetiku talazopariba.
English: Please see section “Male and female contraception” below.
Croatian: Vidjeti dio „Muška i ženska kontracepcija“ u nastavku.
English: A series of prespecified subgroup PFS analyses was performed based on prognostic factors and baseline characteristics to investigate the internal consistency of treatment effect.
Croatian: Serija prethodno određenih analiza PFS-a podskupina provedena je na temelju prognostičkih čimbenika i početnih karakteristika kako bi se ispitala interna konzistencija učinka liječenja.
English: Your doctor may want to test your bone marrow to check for these problems.
Croatian: Liječnik će možda htjeti ispitati Vašu koštanu srž kako bi provjerio imate li navedene probleme.
English: Talzenna hard capsules come in different strengths.
Croatian: Tvrde kapsule Talzenna isporučuju se u različitim jačinama.
English: Patients with changes (mutations) in genes called BRCA are at risk of developing some forms of cancer.
Croatian: Bolesnici s promjenama (mutacijama) u genima poznatim pod nazivom BRCA pod rizikom su od razvoja nekih oblika raka.
English: Number of patients who received following prior therapies, n (%) Taxane
Croatian: Broj bolesnika koji su prethodno primili sljedeće terapije, n (%) Taksan
English: Concomitant use of strong BCRP inhibitors (including but not limited to curcumin and cyclosporine) should be avoided.
Croatian: Treba izbjegavati istodobnu primjenu jakih inhibitora BCRP-a (uključujući, ali ne ograničavajući se na kurkumin i ciklosporin).
English: Haemoglobin < 8 g/dL
Croatian: Hemoglobin < 8 g/dl
English: OTHER SPECIAL WARNING(S), IF NECESSARY 8.
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A), AKO JE POTREBNO
English: Number of patients at risk
Croatian: Bolesnici izloženi riziku
English: No dose adjustment is necessary in elderly (≥ 65 years of age) patients (see section 5.2).
Croatian: Nije potrebna prilagodba doze u starijih osoba (≥ 65 godina) (vidjeti dio 5.2).
English: What Talzenna is and what it is used for 2.
Croatian: Što je Talzenna i za što se koristi 2.
English: If you feel dizzy, weak, or tired (these are very common side effects of Talzenna), you should not drive or use machines.
Croatian: Ako osjećate omaglicu, slabost ili umor (to su vrlo česte nuspojave lijeka Talzenna), ne biste smjeli upravljati vozilima ili raditi sa strojevima.
English: If you forget to take Talzenna
Croatian: Ako ste zaboravili uzeti lijek Talzenna
English: Talazoparib did not have a clinically relevant effect on QTc prolongation at the maximum clinically recommended dose of 1 mg once daily.
Croatian: Talazoparib nije imao klinički relevantan učinak na produljenje QTc-a pri maksimalnoj klinički preporučenoj dozi od 1 mg jednom na dan.
English: Talazoparib undergoes minimal hepatic metabolism in humans.
Croatian: Talazoparib podliježe minimalnom jetrenom metabolizmu u ljudi.
English: How much to take The recommended dose is one 1-mg capsule taken by mouth once daily.
Croatian: Koliko lijeka trebate uzeti Preporučena doza je jedna kapsula od 1 mg koja se uzima kroz usta jednom dnevno.
English: Overall, MDS/AML has been reported in 2 out of 584 (0.3%) solid tumour patients treated with talazoparib in clinical studies.
Croatian: Ukupno gledano MDS/AML je prijavljen u 2 od 584 (0,3 %) bolesnika koji boluju od solidnih tumora liječenih talazoparibom u kliničkim ispitivanjima.
English: Consistent with the overall results, a reduction in the risk of disease progression or death in favour of the talazoparib arm was observed in all individual patient subgroups (Figure 2).
Croatian: U skladu s ukupnim rezultatima, smanjenje rizika progresije bolesti ili smrti u korist skupine liječene talazoparibom zabilježeno je u svim pojedinačnim podskupinama bolesnika (slika 2).
English: Treatment with Talzenna should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.
Croatian: Liječenje lijekom Talzenna treba započeti i nadzirati liječnik koji ima iskustva u primjeni lijekova protiv raka.
English: Curcumin (e.g. found in turmeric root) in some medicines (see also section Talzenna with food and drink below).
Croatian: - Kurkumin (npr. može se naći u korijenu kurkume) u nekim lijekovima (vidjeti dio Talzenna s hranom i pićem).
English: b. Stratified Log-rank test. c. 51% of the projected final number of OS events occurred (163 of 321 deaths).
Croatian: 51 % projiciranog konačnog broja događaja OS-a se ostvarilo (163 od 321 smrti).
English: No deaths were reported due to myelosuppression-related adverse reactions.
Croatian: Nisu zabilježeni smrtni slučajevi do kojih je došlo zbog nuspojava povezanih s mijelosupresijom.
English: The median duration of exposure was 5.4 months (range 0.03-61.1).
Croatian: Medijan trajanja izlaganja iznosio je 5,4 mjeseci (raspon od 0,03 do 61,1).
English: Male and female contraception
Croatian: Muška i ženska kontracepcija
English: Twenty-eight percent (28%) of the patients in the pivotal study were taking acid-reducing agents, mainly proton pump inhibitors.
Croatian: Dvadeset i osam posto (28 %) bolesnika u pivotalnom ispitivanju su uzimali lijekove za smanjenje kiseline, uglavnom inhibitore protonske pumpe.
English: Talzenna works by blocking PARP, which is an enzyme that repairs damaged DNA in certain cancer cells.
Croatian: Talzenna djeluje tako da blokira PARP, enzim koji popravlja oštećenu DNK u određenim stanicama raka.
English: Pharmacokinetics of talazoparib have not been evaluated in patients < 18 years of age.
Croatian: Farmakokinetika talazopariba nije procijenjena u bolesnika u dobi od < 18 godina.
English: The study demonstrated a statistically significant improvement in PFS for Talzenna compared with chemotherapy (see Table 5).
Croatian: Ispitivanje je dokazalo statistički značajno poboljšanje PFS-a za lijek Talzenna u usporedbi s kemoterapijom (vidjeti tablicu 5).
English: Serious problems with the bone marrow
Croatian: Ozbiljni problemi s koštanom srži
English: This is probably the net effect of both P-gp induction and inhibition by rifampin under the tested conditions in the drug-drug interaction study.
Croatian: To je vjerovatno neto učinak i indukcije i inhibicije P-gp-a rifampinom pod ispitanim uvjetima u ispitivanju interakcije između lijekova.
English: Your healthcare provider will perform a test to make sure that Talzenna is right for you.
Croatian: Zdravstveni radnik će provesti pretrage kako bi bio siguran da je Talzenna primjerena za Vas.
English: How to store Talzenna 6.
Croatian: Kako čuvati lijek Talzenna 6.
English: This clastogenicity is consistent with genomic instability resulting from the primary pharmacology of talazoparib, indicating the potential for genotoxicity in humans.
Croatian: Ova klastogenost je u skladu s genomskom nestabilnošću koja proizlazi iz primarne farmakologije talazopariba i ukazuje na potencijal genotoksičnosti u ljudi.
English: Genetic counselling for patients with BRCA mutations should be performed according to local regulations, as applicable.
Croatian: Genetičko savjetovanje za bolesnike s mutacijama gena BRCA potrebno je provesti sukladno nacionalnim propisima, koliko je primjenjivo.
English: It is a type of anticancer medicine known as a ‘PARP (poly-ADP ribose polymerase) inhibitor'.
Croatian: To je tip lijeka protiv raka poznat kao „inhibitor PARP-a“ (poli -ADP riboza polimeraza).
English: Clarithromycin and erythromycin antibiotics - used to treat bacterial infections.
Croatian: - Antibiotici klaritromicin i eritromicin - koriste se za liječenje bakterijskih infekcija.
English: No significant effect of acid-reducing agents on talazoparib exposure is expected, given sufficient solubility of talazoparib at all pHs between 1 and 6.8.
Croatian: Ne očekuje se značajan učinak lijekova za smanjenje kiseline na izloženost talazoparibu s obzirom na dostatnu topljivost talazopariba pri svim pH vrijednostima između 1 i 6,8.
English: Talk to your healthcare provider about birth control methods that may be right for you.
Croatian: Razgovarajte s Vašim zdravstvenim radnikom o metodama protiv začeća koje mogu biti primjerene za Vas.
English: In the event of overdose, treatment with talazoparib should be stopped, and physicians should consider gastric decontamination, follow general supportive measures and treat symptomatically.
Croatian: U slučaju predoziranja potrebno je zaustaviti liječenje talazoparibom, a liječnici trebaju razmotriti dekontaminaciju želuca, slijediti opće suportivne mjere i provesti simptomatsko liječenje.
English: Talazoparib should not be started until patients have recovered from haematological toxicity caused by previous therapy (≤ Grade 1).
Croatian: Ne smije se započeti s primjenom talazopariba dok se bolesnici ne oporave od hematološke toksičnosti koju je uzrokovala prethodna terapija (≤ stupanj 1).
English: Excretion of unchanged talazoparib in urine was the major route of elimination accounting for 55% of the administered dose, while unchanged talazoparib recovered in the faeces accounted for 14%.
Croatian: Izlučivanje nepromijenjenog talazopariba u urinu bio je glavni put eliminacije odgovoran za 55 % primijenjene doze, dok je nepromijenjeni talazoparib pronađen u stolici bio odgovoran za 14 %.
English: Dose modifications (dose reductions or dose interruptions) due to any adverse reaction occurred in 62.3% of patients receiving Talzenna.
Croatian: Promjene doze (smanjenja doze ili privremeni prekidi) zbog bilo koje nuspojave dogodile su se kod 62,3 % bolesnika koji su primali lijek Talzenna.
English: Potential contributing factors for the development of MDS/AML include previous platinum-containing chemotherapy, other DNA damaging agents or radiotherapy.
Croatian: Potencijalni čimbenici koji pridonose razvoju MDS/AML uključuju prethodnu kemoterapiju koja sadrži platinu, druge lijekove koji oštećuju DNK ili radioterapiju.
English: Fertility Talazoparib may reduce fertility in men.
Croatian: Plodnost Talazoparib može smanjiti plodnost u muškaraca.
English: Based on non-clinical findings in testes (partially reversible) and ovary (reversible), Talzenna may impair fertility in males of reproductive potential (see section 5.3).
Croatian: Na temelju nekliničkih nalaza na testisima (djelomično reverzibilni) i jajniku (reverzibilni) lijek Talzenna može smanjiti plodnost u muškaraca reproduktivne dobi (vidjeti dio 5.3).
English: Do not use this medicine after the expiry date which is stated on the carton and the bottle or blister after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i bočici ili blisteru iza oznake „EXP“.
English: Rarely, low blood cell counts may be a sign of more serious problems with the bone marrow such as myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML).
Croatian: U rijetkim slučajevima nizak broj krvnih stanica može biti znak ozbiljnijih problema s koštanom srži poput mijelodisplastičnog sindroma (MDS) ili akutne mijeloične leukemije (AML).
English: Food intake decreased the rate but not the extent of talazoparib absorption.
Croatian: Unos hrane smanjio je stopu, ali ne i omjer apsorpcije talazopariba.
English: Your doctor will perform a pregnancy test prior to starting Talzenna.
Croatian: Liječnik će zatražiti od Vas da napravite test na trudnoću prije početka liječenja lijekom Talzenna.
English: Itraconazole and ketoconazole - used to treat fungal infections.
Croatian: - Itrakonazol i ketokonazol - koriste se za liječenje gljivičnih infekcija.
English: Based on these results, Talzenna can be administered with or without food (see section 4.2).
Croatian: Na temelju tih rezultata lijek Talzenna može se uzimati sa hranom ili bez nje (vidjeti dio 4.2).
English: Lapatinib - used to treat patients with certain types of breast cancer.
Croatian: - Lapatinib - koristi se za liječenje bolesnika s određenim tipovima raka dojke.
English: The European Medicines Agency has waived the obligation to submit the results of studies with talazoparib in all subsets of the paediatric population in breast cancer (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja talazopariba u svim podskupinama pedijatrijske populacije kod raka dojke (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: When the strong P-gp inhibitor is discontinued, the Talzenna dose should be increased (after 3‐5 half-lives of the P-gp inhibitor) to the dose used prior to the initiation of the strong P-gp inhibitor (see section 4.5).
Croatian: Kada se prekine primjena jakog inhibitora P-gp-a, treba povećati dozu lijeka Talzenna (nakon 3-5 poluvijekova inhibitora P-gp-a) na dozu koja je korištena prije uvođenja jakog inhibitora P-gpa (vidjeti dio 4.5).
English: Pregnant women should be advised of the potential risk to the foetus (see section 4.6).
Croatian: Potrebno je upozoriti trudnice o mogućem riziku za fetus (vidjeti dio 4.6).
English: Patients with prior platinum therapy for advanced disease were required to have no evidence of disease progression during platinum therapy.
Croatian: U bolesnika koji su prethodno primili terapiju na bazi platine za uznapredovalu bolest nisu se smjeli pokazati znakovi progresije bolesti tijekom terapije platinom.
English: Following oral administration of talazoparib, the median time to Cmax (Tmax) was generally between 1 to 2 hours after dosing.
Croatian: Nakon peroralne primjene talazopariba medijan vremena do Cmax (Tmax) uglavnom se kretao između 1 do 2 sata nakon doziranja.
English: Patients should have been previously treated with an anthracycline and/or a taxane in the (neo)adjuvant, locally advanced or metastatic setting unless patients were not suitable for these treatments (see section 5.1).
Croatian: Bolesnici su prethodno trebali biti liječeni antraciklinom i/ili taksanom u (neo)adjuvantnom, lokalno uznapredovalom ili metastatskom okruženju osim ako ta liječenja nisu bila prikladna za bolesnike (vidjeti dio 5.1).
English: You should not use Talzenna if you are pregnant.
Croatian: Ne smijete koristiti lijek Talzenna ako ste trudni.
English: These toxicity findings are consistent with the pharmacology of talazoparib and its tissue distribution pattern.
Croatian: Ovi rezultati toksičnosti u skladu su s farmakologijom talazopariba i njegovim obrascem distribucije po tkivima.
English: Myelodysplastic syndrome/Acute myeloid leukaemia
Croatian: Mijelodisplastični sindrom/akutna mijeloična leukemija
English: Complete blood counts should be obtained at baseline and monitored monthly for signs of haematologic toxicity during treatment.
Croatian: Potrebno je pribaviti kompletnu krvnu sliku na početku ispitivanja i mjesečno je pratiti radi moguće pojave znakova hematološke toksičnosti tijekom liječenja.
English:  Grade 1
Croatian:  Stupanj 1
English: Drug-drug interaction studies between talazoparib and oral contraceptives have not been conducted.
Croatian: Nisu provedena ispitivanja interakcije lijekova između talazopariba i oralnih kontraceptiva.
English: Talazoparib exposure generally increased proportionally with dose across the range of 0.025 mg to 2 mg after daily administration of multiple doses.
Croatian: Izlaganje talazoparibu uglavnom se povećavalo proporcionalno s dozom u rasponu od 0,025 mg do 2 mg nakon svakodnevne primjene višekratnih doza.
English: The primary efficacy endpoint was progression-free survival (PFS) evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, as assessed by blinded independent central review (BICR).
Croatian: Primarna mjera ishoda djelotvornosti bilo je preživljenje bez progresije bolesti (engl. progression-free survival, PFS) procijenjeno u skladu s Kriterijima za procjenu odgovora kod solidnih tumora (RECIST), verzija 1.1, prema slijepoj neovisnoj centralnoj procjeni (BICR).
English: Do not use this medicine if the pack is damaged or shows signs of tampering.
Croatian: Ovaj lijek se ne smije upotrijebiti ako primijetite da je pakiranje oštećeno ili da pokazuje znakove neovlaštene uporabe.
English: Following repeated daily dosing, plasma talazoparib concentrations reached steady-state within 2 to 3 weeks.
Croatian: Nakon što je primijenjena ponavljana dnevna doza koncentracije talazopariba u plazmi postignule su stanje dinamičke ravnoteže u roku od 2 do 3 tjedna.
English: Do not use curcumin in food supplements while you are taking Talzenna as it may increase Talzenna's side effects.
Croatian: Ne uzimajte kurkumin u dodacima prehrani dok uzimate lijek Talzenna jer može pojačati nuspojave lijeka Talzenna.
English: Also some medicines can affect the way Talzenna works.
Croatian: Također neki lijekovi mogu utjecati na način djelovanja lijeka Talzenna.
English: It is not known if Talzenna passes into breast milk.
Croatian: Nije poznato da li lijek Talzenna prelazi u majčino mlijeko.
English: A total of 431 patients were randomised 2:1 to receive Talzenna 1 mg capsules once daily or chemotherapy at standard doses until progression or unacceptable toxicity.
Croatian: Ukupno je 431 bolesnik bio randomiziran u omjeru 2:1 kako bi primao kapsule lijeka Talzenna od 1 mg jednom na dan ili kemoterapiju u standardnim dozama do progresije ili neprihvatljive toksičnosti.
English: This is because Talzenna can affect the way some other medicines work.
Croatian: To je potrebno jer Talzenna može utjecati na način djelovanja nekih lijekova.
English: Hazard Ratio=0.54 95% CI (0.41, 0.71) p<0.0001
Croatian: Omjer hazarda=0,54 95% CI (0,41; 0,71) p<0.0001
English: Patients with hormone receptor (HR)-positive breast cancer should have been treated with a prior endocrine-based therapy, or be considered unsuitable for endocrine-based therapy.
Croatian: Bolesnici koji boluju od raka dojke s pozitivnim hormonskim receptorima trebali su prethodno primiti terapiju na endokrinoj bazi ili se terapija na endokrinoj bazi smatrala neprikladna za njih.
English: Figure 1 shows the Kaplan-Meier curve for the EMBRACA study.
Croatian: Slika 1 prikazuje Kaplan-Meierovu krivulju za ispitivanje EMBRACA.
English: Permanent discontinuation due to an adverse reaction occurred in 3.6% of patients receiving Talzenna.
Croatian: Trajni prestanak primjene lijeka zbog nuspojave dogodio se kod 3,6 % bolesnika koji su primali lijek Talzenna.
English: The recommended dose is 1 mg talazoparib once daily.
Croatian: Preporučena doza je 1 mg talazopariba jednom na dan.
English: Median age (y [range]) Age category (y), n (%)
Croatian: Medijan dobi (y [raspon]) Kategorija dobi (y), n (%)
English: Abbreviations: CI=confidence interval; PFS=progression-free survival.
Croatian: Kratice: CI=interval pouzdanosti; PFS=preživljenje bez progresije bolesti.
English: Not reported
Croatian: Nije zabilježeno
English: In this PDX model talazoparib decreased tumour growth and increased γH2AX level and apoptosis in the tumours.
Croatian: U ovom je modelu ksenografta bolesnika talazoparib smanjio rast tumora i povećao razinu γH2AX i apoptozu u tumorima.
English: There are no data from the use of Talzenna in pregnant women.
Croatian: Nema podataka o primjeni lijeka Talzenna u trudnica.
English: What you need to know before you take Talzenna
Croatian: Što morate znati prije nego počnete uzimati lijek Talzenna
English: You should not breast-feed while taking Talzenna and for at least 1 month after the last dose.
Croatian: Ne smijete dojiti dok uzimate lijek Talzenna i najmanje 1 mjesec nakon zadnje doze.
English: If co-administration of strong BCRP inhibitors cannot be avoided, patient should be monitored for potential increased adverse reactions.
Croatian: Ako se istodobna primjena jakih inhibitora BCRP-a ne može izbjeći, bolesnike treba pratiti zbog moguće pojave pojačanih nuspojava.
English: Carcinogenicity studies have not been conducted with talazoparib.
Croatian: Ispitivanja kancerogenosti nisu provedena s talazoparibom.
English: Cobicistat, darunavir, indinavir, lopinavir, ritonavir, saquinavir, telaprevir and tipranavir - used to treat HIV infections/AIDS.
Croatian: - Kobicistat, darunavir, indinavir, lopinavir, ritonavir, sakvinavir, telaprevir i tipranavir - koriste se za liječenje HIV infekcija/AIDS-a.
English: Dose adjustments for toxicities Dose level
Croatian: Prilagodbe doze zbog toksičnosti Razina doze
English: PARP enzymes are involved in cellular DNA damage response signalling pathways such as DNA repair, gene transcription, and cell death.
Croatian: PARP enzimi su uključeni u signalne puteve odgovora stanice na oštećenje DNK kao što su popravak DNK, transkripcija gena i smrt stanice.