FrancophonIA/ELRC3.0 huggingface dataset:
English: Effects on reproduction in paediatric patients treated with vandetanib are not known.
Croatian: Učinci na reprodukciju u pedijatrijskih bolesnika liječenih vandetanibom nisu poznati.
English: A single dose pharmacokinetic study in volunteers indicated that hepatic impairment did not affect exposure to vandetanib.
Croatian: Farmakokinetičko ispitivanje jednokratne doze u dobrovoljaca pokazalo je da oštećenje jetre ne utječe na izloženost vandetanibu.
English: There were no statistically significant differences observed for the exploratory endpoint of diarrhoea (reported as stool frequency).
Croatian: Nisu opažene statistički značajne razlike za eksploratorni ishod: proljev (prijavljen kao učestalost stolica).
English: Therefore, RET mutation testing is recommended.
Croatian: Stoga se preporučuje testiranje na mutaciju protoonkogena RET.
English: In addition, vandetanib inhibits epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase in tumour cells and endothelial cells.
Croatian: Dodatno, vandetanib inhibira epidermalnim faktorom rasta stimulirani EGF receptor tirozin kinaze u tumorskim stanicama i endotelnim stanicama.
English: Fourteen patients treated with vandetanib, and 3 with placebo had unresectable locally advanced disease only.
Croatian: Četrnaest bolesnika liječenih vandetanibom i 3 bolesnika koja su primala placebo imala su samo neoperabilnu lokalno uznapredovalu bolest.
English: This study included 331 patients with unresectable locally advanced or metastatic MTC.
Croatian: U ovo je ispitivanje bio uključen 331 bolesnik s neoperabilnim lokalno uznapredovalim ili metastatskim medularnim karcinomom štitnjače.
English: If there is no appropriate alternative therapy, not recommended combinations with vandetanib may be made with additional ECG monitoring of the QTc interval, evaluation of electrolytes and further control at onset or worsening of diarrhoea.
Croatian: Ako nema odgovarajuće terapijske alternative, mogu se primijeniti lijekovi čija se kombinacija s vandetanibom inače ne preporučuje, uz dodatno EKG praćenje QTc-intervala, određivanje elektrolita i daljnje kontrole u slučaju nastupa ili pogoršanja proljeva.
English: The starting dose could be reduced to 200 mg in patients with moderate renal impairment; safety and efficacy have however not been established with 200 mg (see section 4.4).
Croatian: U bolesnika s umjerenim oštećenjem bubrežne funkcije početna se doza može smanjiti na 200 mg; međutim, nisu ustanovljene sigurnost primjene i djelotvornost za dozu od 200 mg (vidjeti dio 4.4).
English: • Disorder of the cornea of the eye (keratopathy).
Croatian: • poremećaj rožnice oka (keratopatija).
English: • As instructed by your doctor or pharmacist
Croatian: • prema uputama liječnika ili ljekarnika.
English: Your doctor or nurse should perform tests to check the levels of your blood potassium, calcium, magnesium, and thyroid-stimulating hormone (TSH) as well as the electrical activity of your heart with a test called an electrocardiogram (ECG).
Croatian: Vaš liječnik ili medicinska sestra trebaju obaviti pretrage da se utvrde razine kalija, kalcija, magnezija i hormona koji stimulira štitnjaču (TSH) u krvi te provjeri električna aktivnost srca pomoću elektrokardiograma (EKG-a).
English: The result of the primary analysis of PFS showed a statistically significant improvement in PFS for patients randomised to vandetanib compared to placebo (Hazard Ratio (HR) = 0.46; 95% Confidence Interval (CI) = 0.31-0.69; p=0.0001).
Croatian: Rezultat primarne analize PFS-a pokazao je statistički značajno poboljšanje PFS-a za bolesnike randomizirane na terapiju vandetanibom u usporedbi s onima koji su primali placebo (omjer hazarda (HR) = 0,46; 95%-tni interval pouzdanosti (CI) = 0,31 - 0,69, p = 0,0001).
English: If you get side effects always tell your doctor.
Croatian: Ako dobijete nuspojave, uvijek obavijestite liječnika.
English: Vandetanib had no effect on fertility in male rats.
Croatian: Vandetanib nije utjecao na plodnost mužjaka štakora.
English: An ECG, and levels of serum potassium, calcium and magnesium and thyroid stimulating hormone (TSH) should be obtained at baseline, at 1, 3, 6 and 12 weeks after starting treatment and every 3 months for at least a year thereafter.
Croatian: Potrebno je snimiti EKG te odrediti serumske razine kalija, kalcija i magnezija, kao i vrijednosti hormona koji stimulira štitnjaču (TSH) na početku liječenja, nakon 1, 3, 6 i 12 tjedana liječenja te zatim svaka 3 mjeseca tijekom najmanje godinu dana.
English: While you are taking Caprelsa, protect yourself when you go outside by always using sun cream and wearing clothes to avoid exposure to the sun.
Croatian: Dok uzimate lijek Caprelsa, zaštite se kada izlazite tako da uvijek nanesete kremu za sunčanje i nosite odjeću koja će spriječiti izlaganje suncu.
English: ECGs and blood tests should also be obtained as clinically indicated during this period and afterwards.
Croatian: Isto tako, EKG i krvne pretrage u tom razdoblju i nakon njega treba obavljati i sukladno kliničkoj indikaciji.
English: Vandetanib binds to human serum albumin and alpha-1-acid-glycoprotein with in vitro protein binding being approximately 90%.
Croatian: Vandetanib se veže za humani serumski albumin i alfa-1-kiseli glikoprotein, a vezanje na proteine in vitro iznosi oko 90%.
English: Following oral dosing of 14C- vandetanib, unchanged vandetanib and metabolites vandetanib N-oxide and N-desmethyl vandetanib were detected in plasma, urine and feces.
Croatian: Nakon peroralne primjene 14C-vandetaniba, nepromijenjeni vandetanib i metaboliti vandetanib-N-oksid i N-dezmetil-vandetanib nađeni su u plazmi, mokraći i fecesu.
English: PRES is a syndrome of subcortical vasogenic oedema diagnosed by a MRI of the brain, has been observed infrequently with vandetanib treatment in combination with chemotherapy.
Croatian: PRES je sindrom supkortikalnog vazogenog edema koji se dijagnosticira magnetskom rezonancom mozga, povremeno je opažen tijekom liječenja vandetanibom u kombinaciji s kemoterapijom.
English: • Vandetanib is not recommended in paediatric patients with severe renal impairment
Croatian: • vandetanib se ne preporučuje za pedijatrijske bolesnike s teškim oštećenjem bubrega.
English: In healthy subjects, the AUC(0-t) and Cmax for digoxin (P-gp substrate) were increased by 23% and 29% respectively, when given together due to P-gp inhibition by vandetanib.
Croatian: Kod zdravih ispitanika, AUC(0-t) i Cmax digoksina (supstrat P-gp-a) su bili povišeni za 23% odnosno 29% kada je bio primijenjen istodobno, zbog inhibicije P-gp-a vandetanibom.
English: The concomitant use of vandetanib with strong CYP3A4 inducers (such as rifampicin, St John's Wort, carbamazepine, phenobarbital) should be avoided (see section 4.5).
Croatian: Treba izbjegavati istodobnu primjenu vandetaniba i snažnih induktora CYP3A4 (kao što su rifampicin, gospina trava, karbamazepin, fenobarbital) (vidjeti dio 4.5).
English: These usually go away when Caprelsa is stopped.
Croatian: Oni obično nestaju kada se prekine liječenje lijekom Caprelsa.
English: Frequent ECG monitoring of the QTc interval should be continued.
Croatian: Treba nastaviti s čestim EKG kontrolama QTc-intervala.
English: This is uncommon (affects less than 1 in 100 people) but can be life-threatening.
Croatian: Ona je manje česta (javlja se u manje od 1 na 100 osoba), ali može biti opasna po život.
English: a The starting dose is the dose at which treatment should be initiated b Higher vandetanib doses than 150 mg/m2 have not been used in clinical studies in paediatric patients c Patients with an adverse reaction requiring a dose reduction should stop taking vandetanib for at least a week.
Croatian: Početna je doza ona doza kojom treba započeti liječenje b Doze vandetaniba više od 150 mg/m2 nisu se koristile u kliničkim ispitivanjima u pedijatrijskih bolesnika c Bolesnici s nuspojavama koje zahtijevaju smanjenje doze trebaju prestati uzimati vandetanib barem tjedan dana.
English: In a female fertility study, there was a trend towards increased oestrus cycle irregularity, a slight reduction in pregnancy incidence and increase in implantation loss.
Croatian: U istraživanju plodnosti ženki opažen je trend povećanja nepravilnosti estrusnog ciklusa, neznatno smanjenje učestalosti skotnosti i većih gubitaka pri implantaciji.
English: Appropriate clinical and/or laboratory monitoring is recommended for patients receiving concomitant metformin and vandetanib, and such patients may require a lower dose of metformin.
Croatian: Preporučuje se prikladno kliničko i/ili laboratorijsko praćenje za bolesnike koji primaju istodobno vandetanib i metformin, i takvim bolesnicima će možda biti potrebna niža doza metformina.
English: CYP3A4, and vandetanib-N-oxide by flavin-containing monooxygenase enzymes (FM01 and FMO3).
Croatian: N-dezmetil-vandetanib proizvodi prvenstveno CYP3A4, a vandetanib-N-oksid enzimi monooksigenaze koji sadrže flavin (FM01 i FMO3).
English: RET mutation status in Study 58
Croatian: Status mutacije protoonkogena RET u Ispitivanju 58
English: Dosing can be resumed at a reduced dose thereafter when fully recovered from adverse reactions
Croatian: Doziranje se može nastaviti sa smanjenom dozom nakon što se bolesnik potpuno oporavi od nuspojava
English: How to take Caprelsa
Croatian: Kako uzimati Caprelsu
English: • Instructions on how to use the dosing and monitoring guide and the daily tracker for paediatric patients and caregivers.
Croatian: • upute kako koristiti Vodič za doziranje i terapijsko praćenje te Dnevnu tablicu za praćenje za pedijatrijske bolesnike i njegovatelje.
English: Scheduled slit lamp examinations have revealed corneal opacities (vortex keratopathies) in treated patients; however, routine slit lamp examinations are not required for patients receiving vandetanib.
Croatian: Predviđenim pregledima slit-lampom u liječenih su bolesnika otkrivena zamućenja rožnice (vortikozne keratopatije), no rutinski pregledi slit-lampom bolesnika koji primaju vandetanib nisu potrebni.
English: The total daily dose in children must not exceed 300 mg.
Croatian: Ukupna dnevna doza u djece ne smije prijeći
English: Statistically significant advantages were seen for vandetanib for the secondary endpoints of response rate, disease control rate, and biochemical response.
Croatian: Opažene su statistički značajne prednosti vandetaniba u sljedećim sekundarnim ishodima: udjelu odgovora na liječenje, udjelu kontrolirane bolesti i biokemijskom odgovoru.
English: • Upset stomach (dyspepsia).
Croatian: • nadražen želudac (dispepsija).
English: QTc prolongation and Torsades de Pointes
Croatian: Produljenje QTc-intervala i torsades de pointes
English: If a patient presents with respiratory symptoms such as dyspnoea, cough and fever, vandetanib treatment should be interrupted and prompt investigation initiated.
Croatian: Ako se u bolesnika pojave respiratorni simptomi poput dispneje, kašlja i vrućice, liječenje vandetanibom mora se prekinuti i odmah započeti s pretragama.
English: Excretion of the dose was slow and further excretion beyond 21 days would be expected based on the plasma half-life.
Croatian: Izlučivanje doze odvijalo se sporo, a s obzirom na poluvijek u plazmi može se očekivati nastavak izlučivanja i nakon 21 dana.
English: Teeth and bone development abnormalities in pediatric patients
Croatian: Abnormalnosti u razvoju zubi i kosti u pedijatrijskih bolesnika
English: In an animal model of wound-healing, mice dosed with vandetanib had reduced skin-breaking strength compared with controls.
Croatian: U životinjskom modelu zacjeljivanja rana, miševima kojima je primijenjen vandetanib bila je umanjena otpornost na trganje kože u usporedbi s kontrolnim životinjama.
English: Paediatric clinical trial data with vandetanib in MTC (see section 5.1) obtained during drug development is limited to 16 patients aged 9 years to 17 years with hereditary medullary thyroid carcinoma (Study IRUSZACT0098).
Croatian: Podaci iz pedijatrijskih kliničkih ispitivanja vandetaniba za medularni karcinom štitnjače (vidjeti dio 5.1), dobiveni tijekom razvoja lijeka, ograničeni su na 16 bolesnika u dobi od 9 do 17 godina s nasljednim medularnim karcinomom štitnjače (ispitivanje IRUSZACT0098).
English: Table 2: Adverse reactions and system organ class System Organ
Croatian: Tablica 2: Nuspojave i organski sustavi Organski sustav
English: Vandetanib was excreted into milk in rat and found in plasma of pups following dosing to lactating rats.
Croatian: Vandetanib se izlučio u mlijeko štakorica i nađen je u plazmi mladunčadi nakon primjene štakoricama u laktaciji.
English: The administration of vandetanib with substances known to prolong the ECG QTc interval is contraindicated or not recommended (see section 4.3 and 4.5).
Croatian: Primjena vandetaniba s lijekovima za koje je poznato da produljuju QTc-interval je kontraindicirana ili se ne preporučuje (vidjeti dijelove 4.3 i 4.5).
English: The safety findings in this study are consistent with the safety profile of vandetanib in adult patients with MTC.
Croatian: Otkrića o sigurnosti u ovom ispitivanju dosljedna su sa sigurnosnim profilom vandetaniba u odraslih bolesnika s medularnim karcinomom štitnjače.
English: In healthy subjects, no clinically significant interaction was shown between vandetanib (a single dose of 300mg) and the potent CYP3A4 inhibitor, itraconazole (repeated doses of 200mg once daily).
Croatian: Učinak drugih lijekova na vandetanib Kod zdravih ispitanika, nije se pokazala klinički značajna interakcija između vandetaniba (jednokratna doza od 300 mg) i potentnog inhibitora CYP3A4, itrakonazola (ponovljene doze od 200 mg jednom dnevno).
English: ECG QTc prolongation appears to be dose-dependent.
Croatian: Čini se da je produljenje QTc-intervala ovisno o dozi.
English: While you are taking Caprelsa, protect yourself when you go outside by always using sunscreen and wearing clothes to avoid exposure to the sun.
Croatian: Dok uzimate lijek Caprelsa, zaštitite se kada izlazite tako da uvijek nanesete sredstvo za zaštitu od sunca i nosite odjeću koja će spriječiti izlaganje suncu.
English: Patients / caregivers
Croatian: Bolesnici/njegovatelji
English: There is no experience in paediatric patients with hereditary MTC below 9 years of age (see section 5.1).
Croatian: Nema iskustva sa pedijatrijskim bolesnicima mlađim od 9 godina s nasljednim medularnim karcinomom štitnjače (vidjeti dio 5.1).
English: - the clinical study report of study D4200C00104, an observational study including a retrospective arm to evaluate the Benefit/Risk of vandetanib (Caprelsa) 300 mg in RET mutation negative and RET mutation positive patients with symptomatic, aggressive, sporadic, unresectable, locally advanced/metastatic thyroid cancer (MTC).
Croatian: - izvješće kliničkog ispitivanja D4200C00104, opservacijskog ispitivanja koje uključuje retrospektivnu skupinu za procjenu omjera koristi/rizika primjene 300 mg vandetaniba (lijeka Caprelsa) u bolesnika koji imaju negativan status mutacije protoonkogena RET i u bolesnika koji imaju pozitivan status mutacije protoonkogena RET sa simptomatskim, agresivnim, sporadičnim, neoperabilnim, lokalno uznapredovalim/metastatskim karcinomom štitnjače.
English: • Loss of appetite (anorexia).
Croatian: • gubitak teka (anoreksija).
English: • 12 weeks after starting Caprelsa
Croatian: • 12 tjedana nakon početka liječenja lijekom Caprelsa
English: If severe diarrhoea (CTCAE grade 3-4) develops, vandetanib should be stopped until diarrhoea improves.
Croatian: Ako se razvije teški proljev (CTCAE stupnja 3-4), treba prekinuti primjenu vandetaniba dok se proljev ne ublaži.
English: • Information about the risks of QTc prolongation and Torsades de pointes, and Posterior reversible encephalopathy syndrome (PRES);
Croatian: • informacije o rizicima za produljenje QTc-intervala i torsades de pointes te o riziku za sindrom posteriorne reverzibilne encefalopatije (PRES);
English: • Flu.
Croatian: • gripa.
English: The precise mechanism of action of vandetanib in locally advanced or metastatic MTC is unknown.
Croatian: Točan mehanizam djelovanja vandetaniba u lokalno uznapredovalom ili metastatskom medularnom karcinomu štitnjače nije poznat.
English: Your doctor may prescribe a medicine to treat this.
Croatian: Liječnik Vam može propisati lijek za njegovo liječenje.
English: Therefore, an appropriate clinical (e.g. ECG) and/or laboratory monitoring is recommended for patients receiving concomitant digoxin and vandetanib, and such patients may require a lower dose of digoxin.
Croatian: Stoga se preporučuje prikladno kliničko (npr. EKG) i/ili laboratorijsko praćenje za bolesnike koji istodobno primaju digoksin i vandetanib, te će takvim bolesnicima možda biti potrebno smanjiti dozu digoksina.
English: Your doctor may need to prescribe or change your thyroid hormone treatment.
Croatian: Liječnik će Vam možda morati propisati terapiju hormonom štitnjače ili promijeniti takvu terapiju.
English: • Failure of the lungs to function properly.
Croatian: • nemogućnost pravilnog rada pluća.
English: In the blinded comparison of vandetanib vs. placebo, only 2 patients known to be RET negative at all 6 exons received vandetanib and none demonstrated responses.
Croatian: U slijepoj usporedbi vandetaniba i placeba, samo su 2 bolesnika s potvrđenim negativnim statusom RET mutacije na svih 6 eksona primala vandetanib i niti jedan nije odgovorio na liječenje.
English: MARKETING AUTHORISATION HOLDER Genzyme Europe B.V., Paasheuvelweg 25, 1105 BP Amsterdam, The Netherlands
Croatian: Genzyme Europe B.V., Paasheuvelweg 25, 1105 BP Amsterdam, Nizozemska
English: • Swelling caused by excess fluid (oedema).
Croatian: • oteklina uzrokovana viškom tekućine (edem).
English: For patients in whom Rearranged during Transfection (RET) mutation is not known or is negative, a possible lower benefit should be taken into account before individual treatment decision (see important information in sections 4.4 and 5.1).
Croatian: U bolesnika u kojih status mutacije protoonkogena RET nije poznat ili je negativan, prije donošenja odluke o terapiji pojedinog bolesnika treba uzeti u obzir moguću slabiju korist liječenja (vidjeti važne informacije u dijelovima 4.4 i 5.1).
English: • The active substance is vandetanib.
Croatian: • Djelatna tvar je vandetanib.
English: In healthy subjects, the exposure for midazolam (CYP3A4 substrate) was not affected when given together with a single dose of vandetanib at 800 mg.
Croatian: Kod zdravih ispitanika, nije bilo utjecaja na izloženost midazolamu (supstrat CYP3A4) kada je bio primijenjen zajedno s jednokratnom dozom vandetaniba od 800 mg.
English: Vandetanib doses higher than 150 mg/m2 have not been used in clinical studies in paediatric patients.
Croatian: Doze vandetaniba više od 150 mg/m2 nisu bile korištene u kliničkim ispitivanjima na pedijatrijskim bolesnicima.
English: • Inability to heal properly.
Croatian: • nemogućnost pravilnog zacjeljivanja.
English: • Breast-feeding (see section 4.6).
Croatian: • Dojenje (vidjeti dio 4.6).
English: Vandetanib is also a sub-micromolar inhibitor of vascular endothelial receptor-3 tyrosine kinase.
Croatian: Vandetanib je i submikromolarni inhibitor tirozin kinaze vaskularnog endotelnog receptora-3.
English: • The need for an ECG, and serum levels of potassium, calcium and magnesium and thyroid stimulating hormone (TSH) and the times and situations when it should be performed;
Croatian: • Potrebu za kontrolom EKG-a i serumskih razina kalija, kalcija i magnezija te hormona koji stimulira štitnjaču (TSH), kao i podatke o vremenskim točkama i situacijama u kojima treba provoditi te kontrole.
English: The pharmacokinetic parameters of vandetanib in paediatrics MTC patients aged 9-17 years were similar to those in adults.
Croatian: Farmakokinetički parametri vandetaniba u pedijatrijskih bolesnika u dobi od 9 do 17 godina s medularnim karcinomom štitnjače bili su slični onima u odraslih.
English: A statistically significant advantage was seen for vandetanib for the secondary endpoint of time to worsening of pain (derived as a composite endpoint using the worst pain score from BPI and patient reported opioid analgesic use) (vandetanib 49%, placebo 57%, HR 0.61, 97.5%CI 0.43-0.87, p< 0.006: 8 vs. 3 months).
Croatian: Opažena je statistički značajna prednost vandetaniba u sekundarnom ishodu: vrijeme do pogoršanja boli (izvedeno kao kompozitni ishod korištenjem rezultata najjače boli u BPI-u i uporabe opijatnih analgetika koju su prijavili bolesnici) (vandetanib 49%, placebo 57%, HR 0,61; 97,5% CI: 0,43 - 0,87,
English: The lips, nose, eyes and genitals may also be affected.
Croatian: Mogu biti zahvaćene usne, nos, oči i spolovila.
English: • Fainting, dizziness or heart rhythm changes.
Croatian: • nesvjestica, omaglica ili promjene srčanog ritma.
English: • Patients who develop a single value of corrected ECG QTc interval of at least 500 msec should stop taking CAPRELSA.
Croatian: • Bolesnici kojima se na EKG-u utvrdi i samo jedan korigirani QTc-interval od najmanje 500 ms moraju prestati uzimati lijek CAPRELSA.
English: Due to the 19-day half-life, adverse reactions including a prolonged QTc interval may not resolve quickly (see section 4.4).
Croatian: Zbog poluvijeka od 19 dana, nuspojave uključujući produljenje QTc intervala se možda neće brzo povući (vidjeti dio 4.4).
English: Vandetanib is not recommended for use in adult and paediatric patients with hepatic impairment (serum bilirubin greater than 1.5 times upper limit of reference range (ULRR), this criterion does not apply to patients with Gilbert's Disease and alanine aminotransferase (ALT), aspartate aminotransferase (AST), or alkaline phosphatase (ALP) greater than 2.5 times ULRR, or greater than 5.0 times ULRR if judged by the physician to be related to liver metastases), since there is limited data in patients with hepatic impairment, and safety and efficacy have not been established (see section 4.4).
Croatian: Ne preporučuje se primjena vandetaniba u odraslih i pedijatrijskih bolesnika s oštećenjem jetrene funkcije (vrijednosti bilirubina u serumu više od 1,5 puta iznad gornje granice referentnog raspona (GGRR), ovaj kriterij nije primjenjiv za bolesnike s Gilbertovom bolešću, te vrijednosti alanin aminotransferaze (ALT), aspartat aminotransferaze (AST) ili alkalne fosfataze (ALP) više od 2,5 puta veće od GGRR-a ili više od 5,0 puta veće od GGRR-a, ako liječnik prosudi da je to povezano s metastazama u jetri), jer su podaci o primjeni u bolesnika s oštećenjem jetrene funkcije ograničeni, a sigurnost primjene i djelotvornost nisu ustanovljene (vidjeti dio 4.4).
English: Vandetanib also showed evidence of phototoxic potential in an in vitro cytotoxicity assay.
Croatian: Vandetanib je također pokazao fototoksični potencijal u testu citotoksičnosti in vitro.
English: Therefore, the concomitant use of ondansetron with vandetanib is not recommended.
Croatian: Stoga se istodobna primjena ondanzetrona i vandetaniba ne preporučuje.
English: The appropriate interval between discontinuation of vandetanib and subsequent elective surgery required to avoid the risks of impaired wound healing has not been determined.
Croatian: Nije utvrđeno koji je odgovarajući interval između prekida primjene vandetaniba i kasnijeg elektivnog kirurškog zahvata da se izbjegnu rizici otežanog zacjeljivanja rane.
English: Caution should be used when administering vandetanib to patients with brain metastases, as intracranial haemorrhage has been reported.
Croatian: Potreban je oprez kada se vandetanib primjenjuje bolesnicima s metastazama u mozgu, jer je zabilježeno intrakranijalno krvarenje.
English: • cyclosporine and tacrolimus (used to treat transplant rejection), digoxin (used to treat irregular heart rate), and metformin (used to control your blood sugar)
Croatian: • ciklosporin i takrolimus (koriste se u liječenju protiv odbacivanja presadaka), digoksin (koristi se za liječenje nepravilnog srčanog ritma) i metformin (koristi se za kontrolu šećera u krvi)
English: In a repeat-dose toxicity study in rats, there was a decrease in the number of corpora lutea in the ovaries of rats given vandetanib for 1 month.
Croatian: U ispitivanju toksičnosti ponovljenih doza na štakorima zabilježeno je smanjenje broja žutih tijela u jajnicima štakorica koje su primale vandetanib tijekom mjesec dana.