FrancophonIA/ELRC3.0 huggingface dataset:
English: If you have an accumulation of fluid around your lungs, your doctor may decide to remove the fluid before giving you CIAMBRA.
Croatian: Ako Vam se oko pluća nakupila tekućina, liječnik može odlučiti ukloniti tu tekućinu prije primjene lijeka CIAMBRA.
English: 06861 Dessau-Roßlau Germany
Croatian: 06861 Dessau-Roßlau
English: If you are unsure, ask your doctor or pharmacist if any of your medicines are NSAIDs.
Croatian: Ako niste sigurni, pitajte svog liječnika ili ljekarnika da li je koji od
English: The polyglutamate forms are retained in cells and are even more potent inhibitors of TS and GARFT.
Croatian: Poliglutamatni se oblici zadržavaju u stanicama i još su snažniji inhibitori enzima TS i GARFT.
English: Corticosteroids: your doctor will prescribe you steroid tablets (equivalent to 4 milligram of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after CIAMBRA treatment.
Croatian: Kortikosteroidi: liječnik će Vam propisati tablete kortikosteroida (u dozi koja odgovara 4 miligrama deksametazona, dvaput na dan) koje ćete morati uzimati dan prije, na sam dan i dan nakon primjene lijeka CIAMBRA.
English: The pH of the reconstituted solution is between 6.6 and 7.8.
Croatian: pH rekonstituirane otopine je između 6,6 i 7,8
English: Pharmacotherapeutic group: antineoplastic agents, folic acid analogues, ATC code: L01BA04
Croatian: Farmakoterapijska skupina: antineoplastici, analozi folatne kiseline; ATK oznaka: L01BA04
English: Pemetrexed solutions are for single use only.
Croatian: Otopine pemetrekseda namijenjene su samo za jednokratnu primjenu.
English: There are many sorts of NSAIDs with different durations of activity.
Croatian: Postoji mnogo vrsta nesteroidnih protuupalnih lijekova s različitim trajanjem djelovanja.
English: Your doctor may decide to change the dose or delay treating you depending on your general condition and if your blood cell counts are too low.
Croatian: Vaš liječnik može odlučiti promijeniti dozu ili odgoditi liječenje, ovisno o Vašem općem stanju te ako je broj Vaših krvnih stanica prenizak.
English: Sexually mature males are advised not to father a child during the treatment and up to 6 months thereafter.
Croatian: Spolno zrelim muškarcima se savjetuje da ne začinju dijete tijekom liječenja i do šest mjeseci po njegovu završetku.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C or 15°C to 25°C.
Croatian: Ako se ne primijeni odmah, vrijeme i uvjeti čuvanja lijeka prije primjene odgovornost su korisnika i ne smiju biti dulji od 24 sata na temperaturi od 2oC do 8oC ili od 15 oC do 25oC.
English: If you are concerned about any side effects, talk to your doctor.
Croatian: Ako ste zabrinuti zbog bilo koje nuspojave, obratite se svom liječniku.
English: Of the randomised patients, 44.9% had a complete/partial response and 51.9% had a response of stable disease to pemetrexed plus cisplatin induction.
Croatian: Od svih randomiziranih bolesnika njih je 44,9% imalo kompletan/djelomičan odgovor na uvodno liječenje pemetreksedom i cisplatinom a 51,9% njih je imalo odgovor u obliku stabilne bolesti.
English: Thus, drainage of third space fluid collection prior to pemetrexed treatment should be considered, but may not be necessary.
Croatian: Stoga je prije početka liječenja pemetreksedom potrebno razmotriti drenažu tekućine iz transcelularnog prostora, no ona možda neće biti nužna.
English: If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with CIAMBRA.
Croatian: Ako ste nedavno cijepljeni, obavijestite o tome svog liječnika jer to može izazvati štetne učinke uz primjenu lijeka CIAMBRA.
English: The separation between the treatment arms was achieved by improvement in lung function in the pemetrexed /cisplatin arm and deterioration of lung function over time in the control arm.
Croatian: Razlike među skupinama očitovale su se poboljšanjem plućne funkcije u skupini pemetreksed/cisplatin i pogoršanjem plućne funkcije tijekom vremena u kontrolnoj skupini.
English: Therefore, the use of pemetrexed in patients with creatinine clearance of < 45 ml/min is not recommended (see section 4.2).
Croatian: Stoga se primjena pemetrekseda u bolesnika s klirensom kreatinina <45 ml/min ne preporučuje (vidjeti dio 4.2).
English: During post marketing surveillance, the following adverse reactions have been reported in patients treated with pemetrexed:
Croatian: Tijekom praćenja nakon stavljanja lijeka u promet prijavljene su sljedeće nuspojave u bolesnika liječenih pemetreksedom:
English: CIAMBRA in combination with cisplatin
Croatian: CIAMBRA u kombinaciji s cisplatinom
English: The high intra-individual variability of the coagulation status during diseases and the possibility of interaction between oral anticoagulants and anticancer chemotherapy require increased frequency of INR (International Normalised Ratio) monitoring, if it is decided to treat the patient with oral anticoagulants.
Croatian: Radi velike intraindividualne varijabilnosti koagulacijskog statusa tijekom bolesti i moguće interakcije između peroralnih antikoagulansa i antitutumorske kemoterapije, nužno je češće praćenje INR-a (internacionalnog normaliziranog omjera) ako se bolesnika odluči liječiti peroralnim antikoagulansima.
English: 95% CI = 1.08-2.26, p = 0.018).
Croatian: 1,08-2,26; p = 0,018).
English: Results from in vitro studies with human liver microsomes indicated that pemetrexed would not be predicted to cause clinically significant inhibition of the metabolic clearance of drugs metabolised by CYP3A, CYP2D6, CYP2C9, and CYP1A2.
Croatian: Rezultati in vitro ispitivanja na ljudskim jetrenim mikrosomima upućuju na to da pemetreksed ne bi uzrokovao klinički značajnu inhibiciju metaboličkog klirensa lijekova koji se metaboliziraju posredstvom CYP3A, CYP2D6, CYP2C9 i
English: Each pack of CIAMBRA consists of one glass vial with rubber stopper and an aluminium seal with flip off cap, and it is covered with a shrink-wrapped plastic sleeve.
Croatian: Svako pakiranje lijeka CIAMBRA sastoji se od jedne staklene bočice s gumenim čepom i aluminijskim prstenom s „flip-off“ poklopcem, i prekriveno je plastičnom navlakom („shrinkwrapped“).
English: It is not known whether pemetrexed is excreted in human milk and adverse reactions on the suckling child cannot be excluded.
Croatian: Nije poznato izlučuje li se pemetreksed u majčino mlijeko pa se nuspojave u dojenčeta ne mogu isključiti.
English: In the event of suspected overdose, patients should be monitored with blood counts and should receive supportive therapy as necessary.
Croatian: Posumnja li se na predoziranje, treba pratiti krvnu sliku bolesnika, prema potrebi, provesti potporno liječenje.
English: This medicinal product contains 54 mg sodium per vial , equivalent to 2,7% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Croatian: Ovaj lijek sadrži 54 mg natrija po bočici što odgovara 2,7% maksimalnog dnevnog unosa od 2 g natrija prema preporukama SZO za odraslu osobu.
English: NSCLC, maintenance treatment:
Croatian: NSCLC, terapija održavanja
English: Common Pain Edema Renal Disorders Common Renal disorders**** Abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; CTCAE = Common Terminology Criteria for Adverse Event; NCI = National Cancer Institute; SGOT = serum glutamic oxaloacectic aminotransferase; SGPT = serum glutamic pyruvic aminotransferase.
Croatian: Kratice: ALT = alanin aminotransferaza; AST = aspartat aminotransferaza; CTCAE = Common Terminology Criteria for Adverse Event (zajednička terminologija za štetne događaje); NCI = National Cancer Institute (Nacionalni institut za rak); SGOT = serumska glutamat-oksaloctena aminotransferaza); SGPT = serumska glutamat-piruvična aminotransferaza).
English: 75 % of previous dose (both CIAMBRA and cisplatin)
Croatian: 75% prethodne doze (i lijeka CIAMBRA i cisplatina)
English: CIAMBRA 500 mgcontains 54 mg sodium (main component of cooking salt) in each vial.
Croatian: CIAMBRA 500 mg sadrži 54 mg natrija (glavni sastojak kuhinjske soli) u jednoj bočici.
English: Blood clots in the lung blood vessels (pulmonary embolism)
Croatian: Krvni ugrušci u krvnim žilama pluća (plućna embolija)
English: Treatment with CIAMBRA should be discontinued if a patient experiences any haematologic or nonhaematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed.
Croatian: Liječenje lijekom CIAMBRA se mora prekinuti ako se u bolesnika pojavi bilo kakva hematološka ili nehematološka toksičnost stupnja 3 ili 4 nakon dvaju sniženja doze, odnosno odmah ako se ustanovi neurotoksičnost stupnja 3 ili 4.
English: - The active substance is pemetrexed.
Croatian: - Djelatna tvar je pemetreksed.
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1000 micrograms) that you must take once a day while you are taking CIAMBRA.
Croatian: Vitaminska nadoknada: liječnik će Vam propisati folatnu kiselinu (vitamin) koja se uzima kroz usta ili multivitaminski pripravak koji sadrži folatnu kiselinu (350 do 1000 mikrograma), koji morate uzimati jedanput na dan dok primate lijek CIAMBRA.
English: Cases of radiation recall have been reported in patients who received radiotherapy weeks or years previously.
Croatian: Prijavljeni su slučajevi radijacijske „recall“ reakcije u bolesnika koji su primali radioterapiju tjednima ili godinama ranije.
English: Administration of pemetrexed to male mice resulted in reproductive toxicity characterised by reduced fertility rates and testicular atrophy.
Croatian: Primjena pemetrekseda u mužjaka miševa rezultirala reproduktivnom toksičnošću, čija su obilježja bila smanjena stopa plodnosti i atrofija testisa.
English: The dose of CIAMBRA is 500 milligrams for every square metre of your body's surface area.
Croatian: Kako primjenjivati lijek CIAMBRA Doza lijeka CIAMBRA je 500 miligrama po svakom kvadratnom metru Vaše površine tijela.
English: Not known: frequency cannot be estimated from the available data Lower limb swelling with pain and redness Increased urine output
Croatian: Nepoznato: učestalost se ne može procijeniti na temelju dostupnih podataka Oticanje donjih udova praćeno boli i crvenilom
English: Fully supplemented patients
Croatian: Bolesnici s potpunim nadomjeskom
English: Interactions common to all cytotoxics
Croatian: Interakcije koje su zajedničke svim citotoksičnim lijekovima
English: For instructions on reconstitution and dilution of CIAMBRA before administration, see section 6.6.
Croatian: Za upute o rekonstituciji i razrjeđivanju lijeka CIAMBRA prije primjene, vidjeti dio 6.6.
English: A significant increase in the incidence of possibly study-drug-related Grade 3/4 neutropenia was observed with longer exposure to pemetrexed (≤6 cycles: 3.3%, > 6cycles: 6.4%: p=0.046).
Croatian: Zabilježeno je značajno povećanje incidencije neutropenije stupnja 3/4, moguće povezanosti s ispitivanim lijekom, pri duljoj izloženosti pemetreksedu (≤ 6 ciklusa: 3,3%, > 6 ciklusa: 6,4%: p=0,046).
English: If you have heart disease or a history of heart disease, please tell your doctor.
Croatian: Ako bolujete ili ste ranije bolovali od srčane bolesti, obavijestite o tome svoga liječnika.
English: If you experience tiredness, feeling faint, becoming easily breathless or if you look pale (since you might have less haemoglobin than normal).
Croatian: ako osjetite umor, nesvjesticu, lako osjetite nedostatak zraka ili ste blijedi (budući da možete imati manje hemoglobina nego što je normalno).
English: Paclitaxel, or Docetaxel.
Croatian: paklitakselom ili docetakselom.
English: Fast heart rate
Croatian: Ubrzani otkucaji srca
English: PT A. Menarini Portugal - Farmacêutica, S.A. Tel: +351 210 935 500
Croatian: Menarini Portugal - Farmacêutica, S.A. Tel: +351 210 935 500
English: Less toxicity and reduction in Grade 3/4 haematologic and non-haematologic toxicities such as neutropenia, febrile neutropenia and infection with Grade 3/4 neutropenia were reported when pretreatment with folic acid and vitamin B12 was administered.
Croatian: Manja toksičnost te smanjenje hematološke i nehematološke toksičnosti stupnja 3/4, poput neutropenije, febrilne neutropenije i infekcija praćenih neutropenijom stupnja 3/4 prijavljene su kada je primijenjeno prethodno liječenje folatnom kiselinom i vitaminom B12.
English: The resulting solution is clear and ranges in colour from colourless to yellow or green-yellow without adversely affecting product quality.
Croatian: Dobivena otopina je bistra i u rasponu boja od bezbojne do žute ili zeleno-žute, što ne utječe nepovoljno na kakvoću lijeka. pH
English: The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Croatian: • Periodička izvješća o neškodljivosti Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenim člankom 107(c) stavkom 7 Direktive
English: 6.5 Nature and contents of container
Croatian: 6.5 Vrsta i sadržaj spremnika Staklena bočica tipa
English: - The other ingredients are mannitol (E 421), hydrochloric acid (pH adjustment) and sodium hydroxide (pH adjustment) (see section 2, “Ciambra contains sodium”).
Croatian: Drugi sastojci su manitol (E421), kloridna kiselina (prilagodba pH) i natrijev hidroksid (prilagodba pH) (vidjeti dio 2, „Ciambra sadrži natrij“).
English: Frequency estimate: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1000 to <1/100), Rare (≥1/10,000 to <1/1000), Very rare (<1/10,000) and not known (cannot be estimated from available data).
Croatian: Procjena učestalosti: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Rare cases of bullous conditions have been reported including Stevens-Johnson syndrome and Toxic epidermal necrolysis which in some cases were fatal.
Croatian: Prijavljeni su rijetki slučajevi buloznih stanja, uključujući Stevens-Johnsonov sindrom i toksičnu epidermalnu nekrolizu, koji su u nekim slučajevima imali smrtni ishod.
English: 50% of previous dose (both CIAMBRA and cisplatin)
Croatian: 50% prethodne doze (i lijeka CIAMBRA i cisplatina)
English: If you have had or are going to have radiation therapy, please tell your doctor, as there may be an early or late radiation reaction with CIAMBRA.
Croatian: Ako ste primali ili ćete primati terapiju zračenjem, obavijestite o tome svoga liječnika jer se uz primjenu lijeka CIAMBRA može pojaviti rana ili kasna reakcija na zračenje.
English: Excipient with known effect Each vial contains approximately 54 mg sodium.
Croatian: Pomoćna tvar s poznatim učinkom Jedna bočica sadrži približno 54 mg natrija.
English: Excipients: Mannitol (E 421), hydrochloric acid , sodium hydroxide (see package leaflet for further information).
Croatian: Pomoćne tvari: manitol (E 421), kloridna kiselina, natrijev hidroksid (za dodatne informacije vidjeti uputu o lijeku).
English: CIAMBRA is also a treatment for patients with advanced stage of lung cancer whose disease has progressed after other initial chemotherapy has been used.
Croatian: CIAMBRA je također lijek za bolesnike s uznapredovalim stadijem raka pluća u kojih je bolest napredovala nakon primjene neke druge početne kemoterapije.
English: Do not use CIAMBRA
Croatian: Nemojte primati lijek CIAMBRA
English: In patients with normal renal function (creatinine clearance > 80 ml/min), high doses of non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen > 1600 mg/day) and aspirin at higher dose (> 1.3 g daily) may decrease pemetrexed elimination and, consequently, increase the occurrence of pemetrexed adverse events.
Croatian: U bolesnika s normalnom bubrežnom funkcijom (klirens kreatinina > 80 ml/min), visoke doze nesteroidnih protuupalnih lijekova (NSAIL, poput ibuprofena > 1600 mg/dan) i više doze acetilsalicilatne kiseline (> 1,3 g na dan) mogu smanjiti eliminaciju pemetrekseda i, posljedično povećati pojavnost nuspojava pemetrekseda.
English: Women must use effective contraception during treatment with CIAMBRA.
Croatian: Žene moraju primjenjivati djelotvornu kontracepciju tijekom liječenja lijekom CIAMBRA.
English: CIAMBRA (pemetrexed) is a multi-targeted anti-cancer antifolate agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication.
Croatian: CIAMBRA (pemetreksed) je protutumorski lijek s višestrukim antifolatnim djelovanjem koji djeluje tako da prekida ključne metaboličke procese ovisne o folatima neophodne za umnažanje stanica.
English: The PFS and OS results in patients with squamous cell histology suggested no advantage for pemetrexed over placebo.
Croatian: Rezultati PFS-a i ukupnog preživljenja bolesnika sa skvamoznim stanicama u histološkom nalazu nisu uputili na prednost pemetrekseda u odnosu na placebo.
English: Pemetrexed infusion solutions prepared as directed above are compatible with polyvinyl chloride and polyolefin lined administration sets and infusion bags.
Croatian: Otopine pemetrekseda za infuziju pripremljene na gore opisani način kompatibilne su s infuzijskim priborom i infuzijskim vrećicama od polivinilklorida i poliolefina.
English: The recommended dose of cisplatin is 75 mg/m
Croatian: Preporučena doza cisplatina je 75
English: CIAMBRA may make you feel tired.
Croatian: CIAMBRA može izazvati osjećaj umora.
English: Patients with renal impairment (Standard Cockcroft and Gault formula or Glomerular Filtration Rate measured Tc99m-DPTA serum clearance method)
Croatian: Gaultovom formulom ili metodom mjerenja brzine glomerularne filtracije Tc99m-DPTA.)
English: Once in the cell, pemetrexed is rapidly and efficiently converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase.
Croatian: Kad uđe u stanicu, pemetreksed se djelovanjem enzima folilpoliglutamat sintetaze brzo i učinkovito pretvara u poliglutamatne oblike.
English: CIAMBRA contains sodium
Croatian: CIAMBRA sadrži natrij
English: In addition, infection with or without fever, diarrhoea, and/or mucositis may be seen.
Croatian: Uz to je moguća i pojava infekcije s vrućicom ili bez nje, proljev i/ili mukozitis.
English: CIAMBRA is also given in combination with cisplatin for the initial treatment of patients with advanced stage of lung cancer.
Croatian: CIAMBRA se također primjenjuje u kombinaciji sa cisplatinom za početno liječenje bolesnika s uznapredovalim stadijem raka pluća.
English: Log Rank p-value* Overall response rate** (95 % CI)
Croatian: Log-rang p-vrijednost* Stopa ukupnog odgovora** (95 % CI) (9 % C)
English: Fisher's exact p-value*
Croatian: Fisherova egzaktna p-vrijednost* Kratica: CI = interval pouzdanosti
English: Dose of CIAMBRA (mg/m
Croatian: Doza lijeka CIAMBRA (mg/m2)
English: Administration of pemetrexed to pregnant mice resulted in decreased foetal viability, decreased foetal weight, incomplete ossification of some skeletal structures and cleft palate.
Croatian: Primjena pemetrekseda u gravidnih ženki miševa rezultirala je smanjenjem preživljenja i tjelesne težine ploda, nepotpunim okoštavanjem nekih koštanih struktura i pojavom rascijepa nepca.
English: Progression free survival (months) Median
Croatian: Preživljenje bez progresije bolesti (mjeseci) Medijan
English: Concomitant administration of substances that are also tubularly secreted (e.g. probenecid, penicillin) could potentially result in delayed clearance of pemetrexed.
Croatian: Istodobna primjena lijekova koji se također izlučuju tubularnom sekrecijom (npr. probenecid, penicilin) može rezultirati odgođenim klirensom pemetrekseda.
English: All patients received study therapy as initial treatment for locally advanced or metastatic NSCLC and patients in both treatment groups were fully supplemented with folic acid and vitamin B12.
Croatian: Svi su bolesnici primali ispitivanu terapiju kao početnu terapiju za lokalno uznapredovali ili metastatski rak pluća nemalih stanica, te su bolesnici u obje skupine primali i potpun nadomjestak folatne kiseline i vitamina B12.
English: Rare cases of radiation recall have been reported in patients who have received radiotherapy previously (see section 4.4).
Croatian: Slučajevi „recall“ radijacijske reakcije prijavljeni su rijetko u bolesnika koji su prethodno primali radioterapiju (vidjeti dio 4.4).
English: In vitro studies have shown that pemetrexed behaves as a multitargeted antifolate by inhibiting thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotides.
Croatian: Ispitivanja in vitro pokazala su da se pemetreksed djeluje antifolatno na više načina, inhibirajući timidilat sintetazu (TS), dihidrofolat reduktazu (DHFR) i glicinamid ribonukleotid formiltransferazu (GARFT), enzima ovisnih o folatima i ključnih za de novo biosintezu timidinskih i purinskih nukleotida.
English: Due to the increased thrombotic risk in patients with cancer, the use of anticoagulation treatment is frequent.
Croatian: Zbog povećanog rizika od tromboze u onkoloških bolesnika, često se daje antikoagulantna terapija.
English: The analysis of the impact of NSCLC histology on overall survival demonstrated clinically relevant differences in survival according to histology, see table below.
Croatian: Analiza utjecaja histologije NSCLC-a na ukupno preživljenje pokazala je klinički značajnu razliku u preživljenju s obzirom na histološki tip tumora, vidjeti tablicu u nastavku.
English: ** Refer to NCI CTCAE Criteria (Version 3.0; NCI 2003) for each grade of toxicity.
Croatian: ** Za sve stupnjeve toksičnosti vidjeti NCI CTCAE kriterije (Verzija 3.0; NCI 2003).
English: Rash/ desquamation Common Pruritus Alopecia
Croatian: deskvamacija često pruritus alopecija
English: Serious cardiovascular events, including myocardial infarction and cerebrovascular events have been uncommonly reported during clinical studies with pemetrexed, usually when given in combination with another cytotoxic agent.
Croatian: Ozbiljni kardiovaskularni događaji, uključujući infarkt miokarda i cerebrovaskularne događaje, manje često su prijavljeni tijekom kliničkih ispitivanja pemetrekseda, obično kad se lijek davao u kombinaciji s drugim citotoksičnim lijekom.
English: For storage conditions after reconstitution/dilution of the medicinal product, see section 6.3.
Croatian: Uvjete čuvanja nakon rekonstitucije/razrjeđivanja lijeka vidjeti u dijelu 6.3.
English: If concomitant administration of NSAIDs is necessary, patients should be monitored closely for toxicity, especially myelosuppression and gastrointestinal toxicity.
Croatian: bolesnike treba pažljivo nadzirati kako bi se uočili eventualni znakovi toksičnosti, naročito mijelosupresije i gastrointestinalne toksičnosti.
English: If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), CIAMBRA should be withheld until resolution to less than or equal to the patient's pre-therapy value.
Croatian: Razvije li se u bolesnika nehematološka toksičnost stupnja ≥ 3 (osim neurotoksičnosti), primjena lijeka CIAMBRA mora se prekinuti sve dok se vrijednosti ne vrate na razinu prije liječenja ili nižu.