FrancophonIA/ELRC3.0 huggingface dataset:
English: Cobicistat has not been studied in patients with severe hepatic impairment (Child-Pugh Class C).
Danish: Cobicistat er ikke blevet undersøgt hos patienter med svært nedsat leverfunktion (Child-Pugh klasse C).
English: Co-administration of neuroleptics with cobicistat may result in increased plasma concentrations of neuroleptics.
Danish: Samtidig administration af neuroleptika og cobicistat kan resultere i øgede plasmakoncentrationer af neuroleptika.
English: See sections 4.2, 4.8 and 5.2.
Danish: 4.2, 4.8 og 5.2.
English: ORAL ANTI-DIABETICS Metformin
Danish: ORALE ANTIDIABETIKA Metformin
English: Tybost contains the azo colouring agent sunset yellow FCF (E110), which may cause allergic reactions.
Danish: Hjælpestoffer Tybost indeholder azo-farvestoffet sunset yellow FCF (E110), som kan forårsage allergiske reaktioner.
English: Changes in CD4+ cell counts through 48 and 144 weeks in Study GS-US-216-0114 are presented in Table 8.
Danish: Ændringer i CD4+ celletal til og med uge 48 og 144 i studie GS-US-216-0114 vises i tabel 8.
English: Co-administration of Tybost with medicinal products that are substrates of these transporters can result in increased plasma concentrations of the co-administered medicinal products (see section 4.4).
Danish: Samtidig administration af Tybost og lægemidler, der er substrater fra disse transporterstoffer, kan resultere i øgede plasmakoncentrationer af de samtidigt indgivne lægemidler (se pkt.
English: Caution is warranted and clinical monitoring is recommended during co-administration.
Danish: Der rådes til forsigtighed og klinisk overvågning ved samtidig administration.
English: Tybost 150 mg film-coated tablets
Danish: Tybost 150 mg filmovertrukne tabletter
English: Tybost 150 mg film-coated tablets cobicistat
Danish: Tybost 150 mg filmovertrukne tabletter cobicistat
English: • nevirapine
Danish: • nevirapin
English: Each tablet contains 59 micrograms sunset yellow FCF aluminium lake (E110).
Danish: Hjælpestof(fer), som behandleren skal være opmærksom på Hver tablet indeholder 59 mikrogram sunset yellow FCF aluminium lake (E110).
English: Nevirapine
Danish: Nevirapin
English: Co-administration of cobicistat with medicinal products that inhibit CYP3A may decrease the clearance of cobicistat, resulting in increased cobicistat plasma concentrations (see section 4.5).
Danish: Samtidig administration af cobicistat med lægemidler, som hæmmer CYP3A kan nedsætte clearance af cobicistat, hvilket resulterer i øgede plasmakoncentrationer af cobicistat (se pkt.
English: Co-administration of rilpivirine and cobicistat is expected to increase the plasma concentration of rilpivirine.
Danish: Samtidig administration af rilpivirin og cobicistat forventes at øge plasmakoncentrationen af rilpivirin.
English: • One tablet each day by mouth, with food.
Danish: Den anbefalede dosis for voksne er: • En tablet om dagen gennem munden sammen med mad.
English: Co-administration of cobicistat with carbamazepine is contraindicated (see section 4.3).
Danish: Samtidig administration af cobicistat og carbamazepin er kontraindiceret (se pkt.
English: • blood in the urine (haematuria)
Danish: • blod i urinen (hæmaturi)
English: Carbamazepine, a potent CYP3A inducer, decreases cobicistat plasma concentrations and that of atazanavir or darunavir, which may result in loss of therapeutic effect and development of resistance.
Danish: Carbamazepin, en potent CYP3Ainduktor, reducerer plasmakoncentrationerne af cobicistat og af atazanavir eller darunavir, hvilket kan forårsage svigtende terapeutisk virkning og udvikling af resistens.
English: Concentrations of these sedatives/hypnotics may be increased when co-administered with cobicistat.
Danish: Koncentrationer af disse sedativa/hypnotika kan øges ved samtidig administration af cobicistat.
English: alfuzosin, used to treat an enlarged prostate gland amiodarone, quinidine, used to correct irregular heartbeats dabigatran, used to prevent and treat blood clots carbamazepine, phenobarbital, phenytoin, used to prevent seizures rifampicin, used to prevent and treat tuberculosis and other infections dihydroergotamine, ergometrine, ergotamine, used to treat migraine headache
Danish: alfuzosin, anvendes til at behandle en forstørret blærehalskirtel dabigatran, anvendes til at forebygge og behandle blodpropper amiodaron, quinidin, anvendes til at korrigere uregelmæssige hjerteslag carbamazepin, phenobarbital, phenytoin, anvendes til at forebygge krampeanfald rifampicin, anvendes til at forebygge og behandle tuberkulose og andre infektioner dihydroergotamin, ergometrin, ergotamin, anvendes til at behandle migræne hovedpine prikbladet perikum (Hypericum perforatum), et naturlægemiddel, der anvendes mod depression og angst lovastatin, simvastatin, anvendes til at sænke kolesterol i blodet pimozid, lurasidon, anvendes til at behandle unormale tanker og følelser sildenafil, anvendes til at behandle pulmonal arteriel hypertension - en lungesygdom, der gør det vanskeligt at trække vejret oralt administreret midazolam, triazolam, anvendes til at hjælpe dig med at sove og/eller lindre angst
English: ANTI-GOUT Colchicine
Danish: MIDLER MOD PODAGRA Colchicin
English: When clarithromycin is co-administered with darunavir/cobicistat, consult the darunavir Summary of Product Characteristics for dosing recommendations.
Danish: Når clarithromycin administreres samtidig med darunavir/cobicistat, konsulteres darunavirs produktresumé for doseringsanbefalinger.
English: Co-administration of cobicistat with medicinal products that are moderate to weak inducers of CYP3A may result in decreased plasma concentration of cobicistat and consequently that of atazanavir or darunavir being boosted, leading to loss of therapeutic effect and possible development of resistance.
Danish: Samtidig administration af cobicistat med lægemidler, som er moderate til svage induktore af CYP3A kan føre til reducerede plasmakoncentrationer af cobicistat og derved til, at atazanavir og darunavir boostes, hvilket kan forårsage svigtende terapeutisk virkning og mulig udvikling af resistens.
English: Concentrations of voriconazole may increase or decrease when co-administered with cobicistat.
Danish: Koncentrationer af voriconazol kan øges eller reduceres ved samtidig administration af cobicistat.
English: Caution is warranted and clinical monitoring is recommended upon co-administration of these antiarrhythmic medicinal products with Tybost.
Danish: Der rådes til forsigtighed og klinisk overvågning ved samtidig administration af disse antiarytmika og Tybost.
English: Co-administration of cobicistat with medicinal products that inhibit CYP3A may result in increased plasma concentration of cobicistat.
Danish: Samtidig administration af cobicistat med lægemidler, som hæmmer CYP3A kan føre til øgede plasmakoncentrationer af cobicistat.
English: Plasma concentrations of HMG Co-A reductase inhibitors may be increased when co-administered with cobicistat.
Danish: Plasmakoncentrationer af HMG Co-A reduktasehæmmere kan øges ved samtidig administration af cobicistat.
English: The following pack sizes are available: outer cartons containing 1 bottle of 30 film-coated tablets and 90 (3 bottles of 30) film-coated tablets.
Danish: Fås i pakninger, der indeholder 1 tabletbeholder med 30 filmovertrukne tabletter og 90 (3 tabletbeholdere med 30) filmovertrukne tabletter.
English: Therefore, therapy with cobicistat and darunavir should not be initiated during pregnancy, and women who become pregnant during therapy with cobicistat and darunavir should be switched to an alternative regimen (see sections 4.2 and 4.6).
Danish: Derfor bør behandling med cobicistat og darunavir ikke påbegyndes under graviditet, og kvinder, der bliver gravide under behandling med cobicistat og darunavir, skal skiftes til et andet regime (se pkt.
English: Plasma concentrations of, pitavastatin, fluvastatin or pravastatin are expected to increase when co-administered with atazanavir/cobicistat or darunavir/cobicistat.
Danish: Plasmakoncentrationer af pitavastatin, fluvastatin eller pravastatin forventes at stige, når de administreres samtidig med atazanavir/cobicistat eller darunavir/cobicistat.
English: Co-administration of cobicistat with medicinal products that are strong inducers of CYP3A (such as St. John's wort (Hypericum perforatum), rifampicin, carbamazepine, phenobarbital, phenytoin) may result in decreased plasma concentrations of cobicistat and consequently that of atazanavir or darunavir being boosted, leading to loss of therapeutic effect and possible development of resistance (see section 4.3).
Danish: Samtidig administration af cobicistat og lægemidler, som er potente induktorer af CYP3A (såsom prikbladet perikum (Hypericum perforatum), rifampicin, carbamazepin, phenobarbital og phenytoin) kan føre til reducerede plasmakoncentrationer af cobicistat og derved til, at atazanavir eller darunavir boostes, hvilket kan forårsage svigtende terapeutisk virkning og mulig udvikling af resistens (se pkt.
English: HIV-1 RNA < 50 copies/ml Treatment difference -2.2% (95% CI = -7.4%, 3.0%) -2.1% (95% CI = -8.7%, 4.5%)
Danish: -2,1 % (95 % CI = -8,7 %,
English: myalgia
Danish: myalgi
English: Concentrations of warfarin may be affected upon co-administration with cobicistat.
Danish: Koncentrationer af warfarin kan påvirkes ved samtidig administration af cobicistat.
English: Therapy with cobicistat and darunavir should not be initiated during pregnancy, and women who become pregnant during therapy with cobicistat and darunavir should be switched to an alternative regimen (see sections 4.2 and 4.4).
Danish: Behandling med cobicistat og darunavir bør ikke påbegyndes under graviditet, og kvinder, der bliver gravide under behandling med cobicistat og darunavir, skal skiftes til et andet regime (se pkt.
English: • amlodipine, digoxin, diltiazem, disopyramide, felodipine, flecainide, lidocaine, metoprolol,
Danish: • amlodipine, digoxin, diltiazem, disopyramid, felodipin, flecainid, systemisk lidocain, metoprolol, mexiletin, nicardipin, nifedipin, propafenon, timolol og verapamil, lægemidler,
English: For further details, consult the Summary of Product Characteristics for maraviroc.
Danish: Konsultér maravirocs produktresumé for yderligere oplysninger.
English: AUC: ↔ Cmax: ↑ 41% Cmin: ND
Danish: Cmax: ↑ 41 % Cmin: ND
English: Co-administration of carbamazepine, a potent CYP3A inducer, may significantly decrease cobicistat plasma concentrations.
Danish: Samtidig administration af carbamazepin, en potent CYP3A-induktor, kan reducere plasmakoncentrationerne af cobicistat signifikant.
English: Co-administration of bosentan with cobicistat may lead to decreased cobicistat plasma concentrations.
Danish: Samtidig administration af bosentan og cobicistat kan føre til nedsatte plasmakoncentrationer af cobicistat.
English: Concentrations of calcium channel blockers may be increased when co-administered with cobicistat.
Danish: Koncentrationer af calciumkanalblokkere kan øges ved samtidig administration af cobicistat.
English: Therapeutic monitoring is recommended upon co-administration with Tybost.
Danish: Der anbefales terapeutisk overvågning ved samtidig administration af Tybost.
English: Co-administration of tenofovir disoproxil with cobicistat is expected to increase tenofovir plasma concentration.
Danish: Samtidig administration af tenofovirdisoproxil og cobicistat forventes at øge tenofovirplasmakoncentrationen.
English: Concentrations of these medicinal products may be increased when co-administered with cobicistat.
Danish: Koncentrationerne af disse lægemidler kan øges, når de administreres samtidig med cobicistat.
English: Concentrations of norgestimate may be affected on co-administration with cobicistat.
Danish: Koncentrationer af norgestimat kan påvirkes ved samtidig administration af cobicistat.
English: Concentrations of these immunosuppressants may be increased when co-administered with cobicistat.
Danish: Koncentrationer af disse immunosuppressiva kan øges ved administration af cobicistat.
English: Sunset yellow FCF aluminium lake (E110) Macrogol 3350 (E1521)
Danish: Sunset yellow FCF aluminium lake (E110) Macrogol 3350 (E1521) Polyvinylalkohol (delvist hydrolyseret) (E1203) Talkum (E553B)
English: Concentrations of clarithromycin may be increased upon co-administration with cobicistat.
Danish: Koncentrationer af clarithromycin kan øges ved samtidig administration med cobicistat.
English: If you take more Tybost than you should
Danish: Hvis De har taget for meget Tybost
English: ORAL CONTRACEPTIVES Drospirenone/Ethinyloestradiol (3 mg/0.02 mg single dose)/ Darunavir (800 mg once daily)/Cobicistat (150 mg once daily)
Danish: ORALE ANTIKONCEPTIVA Drospirenon/Ethinylestradiol (3 mg/0,02 mg enkeltdosis)/ Darunavir (800 mg én gang dagligt)/Cobicistat (150 mg én gang dagligt)
English: Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Efavirenz (600 mg single dose) Co-administration of efavirenz and cobicistat is expected to decrease cobicistat plasma concentrations.
Danish: Non-nukleosid-revers transkriptase-hæmmere (NNRTI'er) Efavirenz (600 mg enkeltdosis)
English: Co-administration of rifabutin, a potent CYP3A inducer, may significantly decrease cobicistat plasma concentrations.
Danish: Samtidig administration af rifabutin, en potent CYP3Ainduktor, kan reducere plasmakoncentrationerne af cobicistat signifikant.
English: f Plus background regimen of emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg fixed-dose combination
Danish: f Plus baggrundsbehandlingsplan med emtricitabin 200 mg og tenofovirdisoproxilfumarat 300 mg i fastdosis-kombination
English: • etravirine
Danish: • etravirin
English: a Plus background regimen of emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg fixed-dose combination
Danish: a Plus baggrundsbehandlingsplan med emtricitabin 200 mg og tenofovirdisoproxilfumarat 300 mg i fastdosis-kombination
English: If drospirenone/ethinyloestradiol is co-administered with atazanavir/cobicistat clinical monitoring is recommended due to the potential for hyperkalemia.
Danish: Hvis drospirenon/ethinylestradiol administreres samtidig med atazanavir/cobicistat, anbefales klinisk monitorering på grund af risikoen for hyperkaliæmi.
English: Co-administration of nevirapine and cobicistat is expected to decrease cobicistat plasma concentrations.
Danish: Samtidig administration af nevirapin og cobicistat forventes at reducere plasmakoncentrationerne af cobicistat.
English: If drospirenone/ethinyloestradiol is co-administered with atazanavir/cobicistat or darunavir/cobicistat clinical monitoring is recommended due to the potential for hyperkalemia.
Danish: Hvis drospirenon/ethinylestradiol administreres samtidig med atazanavir/cobicistat eller darunavir/cobicistat, anbefales klinisk monitorering på grund af risikoen for hyperkaliæmi.
English: Co-administration of etravirine and cobicistat is expected to decrease cobicistat plasma concentrations.
Danish: Samtidig administration af etravirine og cobicistat forventes at reducere plasmakoncentrationerne af cobicistat.
English: If drospirenone/ethinyloestradiol is co-administered with darunavir/cobicistat clinical monitoring is recommended due to the potential for hyperkalemia.
Danish: Hvis drospirenon/ethinylestradiol administreres samtidig med darunavir/cobicistat, anbefales klinisk monitorering på grund af risikoen for hyperkaliæmi.
English: ANTICONVULSANTS Carbamazepine (200 mg twice daily)/Elvitegravir (150 mg once daily)/Cobicistat (150 mg once daily)
Danish: ANTIKONVULSIVA Carbamazepin (200 mg to gange dagligt)/Elvitegravir (150 mg én gang dagligt)/Cobicistat (150 mg én gang dagligt)
English: Nevirapine plasma concentrations may be increased when co-administered with cobicistat.
Danish: Plasmakoncentrationerne af nevirapin kan øges, når de administreres samtidig med cobicistat.
English: Antimycobacterials Rifabutin (150 mg every other day)/Elvitegravir (150 mg once daily)/Cobicistat (150 mg once daily)
Danish: Antimykobakterielle lægemidler Rifabutin (150 mg hver anden dag)/Elvitegravir (150 mg én gang dagligt)/Cobicistat (150 mg én gang dagligt)
English: Plasma concentrations of digoxin may be increased when co-administered with cobicistat.
Danish: Plasmakoncentrationerne af digoxin kan øges ved samtidig administration af cobicistat.
English: Drospirenone/Ethinyloestradiol (3 mg/0.02 mg single dose)/Atazanavir (300 mg once daily)/Cobicistat (150 mg once daily)
Danish: Drospirenon/Ethinylestradiol (3 mg/0,02 mg enkeltdosis)/A tazanavir (300 mg én gang dagligt)/Cobicistat (150 mg én gang dagligt)
English: Contains sunset yellow FCF aluminium lake (E110), see leaflet for further information.
Danish: Indeholder sunset yellow FCF aluminium lake (E110).
English: Plasma concentrations of drospirenone are increased following administration of drospirenone/ethinyloestradiol with atazanavir/cobicistat or with darunavir/cobicistat.
Danish: Plasmakoncentrationerne af drospirenon øges efter administration af drospirenon/ethinylestradiol samtidig med atazanavir/cobicistat eller med darunavir/cobicistat.
English: Eye disorders: Very common:
Danish: Meget almindelig: gulsot Almindelig:
English: No dose adjustment of cobicistat is required for patients with renal impairment, including those with severe renal impairment.
Danish: Dosisjustering af cobicistat er ikke nødvendigt hos patienter med nedsat eller alvorligt nedsat nyrefunktion.
English: Plasma concentrations of rosuvastatin are increased when co-administered with darunavir/cobicistat.
Danish: Plasmakoncentrationer af rosuvastatin øges ved samtidig administration med darunavir/cobicistat.
English: Atorvastatin (10 mg single dose)/Darunavir (800 mg)/Cobicistat (150 mg once daily)
Danish: Atorvastatin (10 mg enkeltdosis)/Darunavir (800 mg)/Cobicistat (150 mg én gang dagligt)
English: Colchicine plasma concentrations may be increased when co-administered with cobicistat.
Danish: Plasmakoncentrationer af colchicin kan øges ved samtidig administration af cobicistat.
English: Atorvastatin (10 mg single dose)/Atazanavir (300 mg)/Cobicistat (150 mg once daily)
Danish: Atorvastatin (10 mg enkeltdosis)/Atazanavir (300 mg)/Cobicistat (150 mg én gang dagligt)
English: Plasma concentrations of rosuvastatin are increased when co-administered with atazanavir/cobicistat.
Danish: Plasmakoncentrationer af rosuvastatin øges ved samtidig administration med atazanavir/cobicistat.
English: Rosuvastatin (10 mg single dose)/Darunavir (800 mg once daily)/Cobicistat (150 mg once daily)
Danish: Rosuvastatin (10 mg enkeltdosis)/Darunavir (800 mg én gang dagligt)/Cobicistat (150 mg én gang dagligt)
English: What Tybost is and what it is used for What you need to know before you take Tybost How to take Tybost
Danish: Det skal De vide, før De begynder at tage Tybost Sådan skal De tage Tybost Bivirkninger
English: ocular icterus Gastrointestinal disorders: Very common:
Danish: Meget almindelig: okulær icterus Mave-tarm-kanalen:
English: Rosuvastatin (10 mg single dose)/Atazanavir (300 mg once daily)/Cobicistat (150 mg once daily)
Danish: Rosuvastatin (10 mg enkeltdosis)/Atazanavir (300 mg én gang dagligt)/Cobicistat (150 mg én gang dagligt)
English: Plasma concentrations of trazodone may be increased when co-administered with cobicistat.
Danish: Plasmakoncentrationer af trazodon kan øges ved samtidig administration af cobicistat.
English: Plasma concentrations of drospirenone are increased following co-administration of drospirenone/ethinyloestradiol with atazanavir/cobicistat.
Danish: Plasmakoncentrationerne af drospirenon øges efter administration af drospirenon/ethinylestradiol samtidig med atazanavir/cobicistat.
English: nausea
Danish: • kvalme
English: Musculoskeletal and connective tissue disorders: Uncommon:
Danish: Knogler, led, muskler og bindevæv: Ikke almindelig:
English: Plasma concentrations of atorvastatin are increased when co-administered with atazanavir/cobicistat.
Danish: Plasmakoncentrationer af atorvastatin øges ved samtidig administration med atazanavir/cobicistat.
English: Plasma concentrations of atorvastatin are increased when co-administered with darunavir/cobicistat.
Danish: Plasmakoncentrationer af atorvastatin øges ved samtidig administration med darunavir/cobicistat.
English: Concentrations of these antiarrhythmic medicinal products may be increased when co-administered with cobicistat.
Danish: Koncentrationer af disse antiarytmika kan øges ved samtidig administration af cobicistat.
English: Co-administration of cobicistat with medicinal products that induce CYP3A is contraindicated or is not recommended (see sections 4.3 and 4.5) because decreased plasma concentrations of cobicistat could result in plasma levels that are insufficient to achieve adequate pharmacoenhancement of atazanavir or darunavir.
Danish: 4.3 og 4.5), da nedsatte plasmakoncentrationer af cobicistat kan resultere i plasmaniveauer, derer utilstrækkelige til at opnå adækvat øgede plasmakoncentration af atazanavir eller darunavir.
English: • dasatinib, nilotinib, vinblastine and vincristine, medicines used to treat cancer • corticosteroids including betamethasone, budesonide, fluticasone, mometasone,
Danish: • dasatinib, nilotinib, vinblastin og vincristin, lægemidler, der anvendes til at behandle kræft
English: Plasma concentrations of ethinyloestradiol are decreased following co-administration of drospirenone/ethinyloestradiol with darunavir/cobicistat.
Danish: Plasmakoncentrationerne af ethinylestradiol sænkes efter administration af drospirenon/ethinylestradiol samtidig med darunavir/cobicistat.
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Danish: Når De snart ikke har mere af Tybost, skal De bede om mere fra lægen eller på apoteket.
English: Plasma concentrations of drospirenone are increased following co-administration of drospirenone/ethinyloestradiol with darunavir/cobicistat.
Danish: Plasmakoncentrationerne af drospirenon øges efter administration af drospirenon/ethinyloestradiol samtidig med darunavir/cobicistat.
English: • colchicine, a medicine used to treat gout  Tell your doctor if you are taking any of these medicines.
Danish: • colchicin, et lægemiddel, der anvendes til behandling af podagra.
English: depression, sleep disorder Nervous system disorders: Common:
Danish: Nervesystemet: Almindelig:
English: • feeling sick (nausea)
Danish: Meget almindelig: kvalme
English: • ritonavir • cobicistat
Danish: • cobicistat
English: What Tybost looks like and contents of the pack
Danish: Udseende og pakningsstørrelser
English: Concentrations of beta-blockers may be increased when co-administered with cobicistat.
Danish: Koncentrationer af betablokkere kan øges ved samtidig administration af cobicistat.
English: • itchiness
Danish: • ritonavir
English: Talk to your doctor before taking Tybost: • If you are taking another protease inhibitor.
Danish: Kontakt lægen, før De tager Tybost:
English: Invented name Strength Pharmaceutical Form Route of administration Packaging Content (concentration)
Danish: EU-nummer Særnavn Styrke Lægemiddelform Indgivelsesvej Emballage Indhold (Koncentration) Pakningsstørrelse EU/1/02/225/001 Xigris
English: l t o r d
Danish: r l g
English: • Mycamine should not be used during pregnancy unless clearly necessary.
Danish: • Mycamine bør ikke anvendes under graviditet, med mindre det er strengt nødvendigt.
English: • Patients should be carefully monitored for liver damage and for worsening of renal function.
Danish: • Patienter skal nøje overvåges for leverskade og for forværring af nyrefunktionen.
English: ANNEX 127a CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT TO BE IMPLEMENTED BY THE MEMBER STATES
Danish: BILAG 127a BETINGELSER ELLER BEGRÆNSNINGER MED HENSYN TIL EN SIKKER OG EFFEKTIV ANVENDELSE AF LÆGEMIDLET SKAL IMPLEMENTERES AF MEDLEMSLANDENE
English: • To minimise the risk of adaptive regeneration and potentially subsequent liver tumour formation, early discontinuation in the presence of significant and persistent elevation of ALT/AST is recommended.
Danish: • For at formindske risikoen for adaptiv regenerering og potentiel efterfølgende dannelse af levertumorer tilrådes tidlig seponering, hvis der ses signifikant og vedvarende forhøjelse af ALAT/ASAT.