FrancophonIA/ELRC3.0 huggingface dataset:
English: Lymphadenopathy measured by sum of the products of greatest diameters (SPD) as assessed by physical examination.
Croatian: Limfadenopatija mjerena kao zbroj tvorbi najvećeg promjera procijenjenih tijekom liječničkog
English: Each vial contains 1000 mg of ofatumumab in 50 ml.
Croatian: Jedna bočica sadrži 1000 mg ofatumumaba u 50 ml.
English: Median, all patients 95% CI
Croatian: medijan, svi bolesnici 95% CI omjer hazarda p-vrijednost p< 0,001
English: Age was not found to be a significant factor for ofatumumab pharmacokinetics in a cross-study population pharmacokinetic analysis of patients ranging in age from 21 to 87 years of age.
Croatian: Farmakokinetička analiza populacije bolesnika u rasponu dobi od 21 do 87 godina iz više ispitivanja nije pokazala dob kao značajni čimbenik za farmakokinetiku ofatumumaba.
English: • back pain
Croatian: • bol u leđima
English: Arzerra 1000 mg concentrate for solution for infusion ofatumumab
Croatian: Arzerra 1000 mg koncentrat za otopinu za infuziju ofatumumab
English: Arzerra 1000 mg concentrate for solution for infusion
Croatian: Arzerra 1000 mg koncentrat za otopinu za infuziju
English: Arzerra 100 mg concentrate for solution for infusion ofatumumab
Croatian: Arzerra 100 mg koncentrat za otopinu za infuziju ofatumumab
English: Patients who had prior rituximab therapy, either as monotherapy or in combination with other medicinal products, responded to treatment with Arzerra at a similar rate to those who had not had prior rituximab therapy.
Croatian: ORR je iznosio 49% za bolesnike koji nisu reagirali na terapiju fludarabinom i alemtuzumabom (za sažetak podataka o djelotvornosti iz ispitivanja vidjeti Tablicu 3.) Bolesnici koji su ranije primali terapiju rituksimabom, bilo kao monoterapiju ili u kombinaciji s drugim lijekovima, na terapiju Arzerrom odgovorili su u sličnoj stopi kao i oni koji ranije nisu primali terapiju rituksimabom.
English: If the first infusion was completed without a severe adverse reaction, the remaining infusions of 1000 mg should be administered over 4 hours (see section 4.2), through a peripheral line or indwelling catheter, according to the schedule below.
Croatian: Ako primjena prve infuzije završi bez teških nuspojava, preostale infuzije doza od 1000 mg potrebno je primijeniti tijekom 4 sata (vidjeti dio 4.2) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu.
English: Arzerra 100 mg concentrate for solution for infusion
Croatian: Arzerra 100 mg koncentrat za otopinu za infuziju
English: If the second infusion was completed without a severe adverse reaction, the remaining infusions (3-12) should be administered over 4 hours (see section 4.2), through a peripheral line or indwelling catheter, according to the schedule below.
Croatian: Ako primjena druge infuzije završi bez teških nuspojava, preostale infuzije (3. do 12.) potrebno je primijeniti tijekom 4 sata (vidjeti dio 4.2) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu.
English: Small intestinal obstruction
Croatian: Oštećenje bubrega
English: The overall response rate (ORR) including complete response (CR) was also assessed by an IRC using the 2008 IWCLL guidelines.
Croatian: Neovisno ocjenjivačko povjerenstvo je na temelju IWCLL smjernica iz 2008. ocijenilo i stopu ukupnog odgovora (engl. overall response rate, ORR), uključujući potpuni odgovor (engl. complete response, CR).
English: - The other ingredients are arginine, sodium acetate (E262), sodium chloride, polysorbate 80
Croatian: - Drugi sastojci su arginin, natrijev acetat (E262), natrijev klorid, polisorbat 80 (E433) dinatrijev edetat (E386), kloridna kiselina (E507) (za podešavanje pH), voda za injekcije (pogledajte
English: Check the Arzerra concentrate for particulate matter and discolouration prior to dilution.
Croatian: Prije razrjeđivanja provjerite sadrži li Arzerra koncentrat čestice i postoji li promjena u boji.
English: SN:
Croatian: Serija:
English: For the first and second infusion, administer over 6.5 hours (see section 4.2), through a peripheral line or indwelling catheter, according to the schedule below:
Croatian: Prvu i drugu infuziju primijenite tijekom 6,5 sati (vidjeti dio 4.2) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu:
English: • Withdraw and discard 15 ml from a 1000 ml bag of sodium chloride 9 mg/ml (0.9%) solution for injection;
Croatian: • Izvucite i uklonite 15 ml otopine natrijevog klorida za injekcije od 9 mg/ml (0,9%) iz vrećice od
English: • Withdraw and discard 50 ml from a 1000 ml bag of sodium chloride 9 mg/ml (0.9%) solution for injection;
Croatian: • Izvucite i uklonite 50 ml otopine natrijevog klorida za injekcije od 9 mg/ml (0,9%) iz vrećice od
English: If the first infusion was completed without a severe adverse reaction, the remaining infusions of 1000 mg should be administered over 4 hours (see section 4.2 of the SmPC), through a peripheral line or indwelling catheter, according to the schedule below.
Croatian: Ako primjena prve infuzije završi bez teških nuspojava, preostale infuzije doza od 1000 mg potrebno je primijeniti tijekom 4 sata (vidjeti dio 4.2 Sažetka opisa svojstava lijeka) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu.
English: For the first infusion, administer over 4.5 hours (see section 4.2), through a peripheral line or indwelling catheter, according to the schedule below:
Croatian: Prvu infuziju primijenite tijekom 4,5 sati (vidjeti dio 4.2) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu:
English: Cytopenias, including prolonged and late-onset neutropenia, have been reported during ofatumumab therapy.
Croatian: Tijekom terapije ofatumumabom prijavljene su citopenije, uključujući dugotrajnu i odgođenu neutropeniju.
English: If the second infusion was completed without a severe adverse reaction, the remaining infusions (3-12) should be administered over 4 hours (see section 4.2 of the SmPC), through a peripheral line or indwelling catheter, according to the schedule below.
Croatian: Ako primjena druge infuzije završi bez teških nuspojava, preostale infuzije (3.-12.) potrebno je primijeniti tijekom 4 sata (vidjeti dio 4.2 Sažetka opisa svojstava lijeka) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu.
English: The overall response rate (ORR) was also assessed by an IRC using the 2008 NCI-WG guidelines.
Croatian: Neovisno ocjenjivačko povjerenstvo je na temelju NCI-WG smjernica iz 2008. ocijenilo i stopu ukupnog odgovora (engl. overall response rate, ORR).
English: Dilution
Croatian: Razrjeđivanje
English: IGHV mutated & ZAP-70 positive (n=35)
Croatian: mutiran IGHV i pozitivna ekspresija
English: Immune system disorders
Croatian: Poremećaji probavnog sustava proljev*
English: For the first and second infusion, administer over 6.5 hours (see section 4.2 of the SmPC), through a peripheral line or indwelling catheter, according to the schedule below:
Croatian: Prvu i drugu infuziju primijenite tijekom 6,5 sati (vidjeti dio 4.2 Sažetka opisa svojstava lijeka) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu:
English: None of the patients had an increase of QTc to >500 msec. A concentration dependent increase in QTc was not detected.
Croatian: Nije primijećeno produljenje QTc intervala ovisno o koncentraciji.
English: For the first infusion, administer over 4.5 hours (see section 4.2 of the SmPC), through a peripheral line or indwelling catheter, according to the schedule below:
Croatian: Prvu infuziju primijenite tijekom 4,5 sati (vidjeti dio 4.2 Sažetka opisa svojstava lijeka) kroz periferni venski put ili trajni kateter, prema niže navedenom rasporedu:
English: Very common side effects These may affect more than 1 in 10 people:
Croatian: Ove se mogu javiti u više od 1 na 10 osoba:
English: Bowel obstruction
Croatian: Prijavljivanje nuspojava
English: Uncommon side effects These may affect up to 1 in 100 people:
Croatian: Ove se mogu javiti u do 1 na 100 osoba:
English: All responses were confirmed after 4 weeks.
Croatian: Svi su odgovori potvrđeni nakon 4 tjedna.
English: You may require medical attention.
Croatian: Možda Vam je potrebna medicinska pomoć.
English: 31 May 2022
Croatian: 31 svibnja 2022.
English: It should only be used, if other medicinal products are not efficacious.
Croatian: Smije se koristiti samo ako drugi lijekovi nisu bili djelotvorni.
English: The liver was also identified as a target organ in rats.
Croatian: Jetra je također identificirana kao ciljni organ u štakora.
English: Take the tablet(s) in the morning with food.
Croatian: Uzimajte tabletu(tablete) ujutro s hranom.
English: - decrease of appetite.
Croatian: Smanjen apetit
English: 2 patients had more than 1 mutation in this category.
Croatian: Dva bolesnika imala su više od jedne mutacije u ovoj kategoriji.
English: No formal studies have been performed to assess the effects of these demographic factors.
Croatian: Nisu provedena formalna ispitivanja radi procjene učinaka navedenih demografskih čimbenika.
English: - if you have any of these symptoms: serious skin rashes.
Croatian: - ako imate bilo koji od ovih simptoma: ozbiljne kožne osipe.
English: No additional deaths or transformations occurred in the ITT population.
Croatian: Nije bilo naknadnih slučajeva smrti ili transformacija u ITT populaciji.
English: Since there is limited information in the elderly, caution should be exercised in these patients.
Croatian: Budući da postoje samo ograničene informacije u starijih osoba, nužan je oprez u tih bolesnika.
English: Your doctor will be aware of this and may ensure you are adequately hydrated and give you other medicines to help prevent it.
Croatian: Vaš liječnik je svjestan toga i može osigurati da ste odgovarajuće hidrirani i dati Vam druge lijekove koji će pomoći to spriječiti.
English: Concentration of radioactivity in milk was up to 8-fold higher than in plasma.
Croatian: Koncentracija radioaktivnosti u mlijeku bila je do 8 puta veća nego u plazmi.
English: - if you have an infection.
Croatian: - ako imate infekciju.
English: When your disease is very severe, your body may not be able to clear all the waste products from the dying cancer cells.
Croatian: Kada je Vaša bolest vrlo teška, Vaše tijelo možda neće moći eliminirati sve otpadne tvari iz odumirućih stanica raka.
English: Final Clinical Study Report:
Croatian: Završno izvješće o kliničkom ispitivanju:
English: Reproductive toxicity and development toxicity
Croatian: Reproduktivna toksičnost i razvojna toksičnost
English: * For efficacy results in the subgroup of patients corresponding to the approved indication, see text above.
Croatian: * Za rezultate djelotvornosti u podskupini bolesnika prema odobrenoj indikaciji, vidjeti gornji tekst.
English: Bosulif should be taken orally once daily with food (see section 5.2).
Croatian: Bosulif se mora uzimati peroralno jedanput dnevno s hranom (vidjeti dio 5.2).
English: This is always important, but especially if you are experiencing frequent or prolonged diarrhoea as described above.
Croatian: To je uvijek važno, ali naročito ako imate česti ili dugotrajni proljev kako je gore opisano.
English: 9/L and less than 1.0×10
Croatian: 9/l i manji od 1,0×10
English: The patient should take the usual prescribed dose on the following day.
Croatian: Bolesnik mora uzeti uobičajenu propisanu dozu sljedećeg dana.
English: Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Bosulif:
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete Bosulif:
English: - if you have ever had or might now have a hepatitis B infection.
Croatian: - ako ste ikada imali ili možda trenutno imate infekciju virusom hepatitisa B.
English: If possible, show the doctor the pack, or this leaflet.
Croatian: Ako je moguće, pokažite liječniku pakiranje ili ovu uputu.
English: This medicine has not been studied in children and adoloscents.
Croatian: Ovaj lijek nije ispitan u djece i adolescenata.
English: A potential risk to the breast-feeding infant cannot be excluded.
Croatian: Ne može se isključiti mogući rizik za dojenče.
English: The presence of hypokalaemia and hypomagnesaemia may further enhance this effect.
Croatian: Prisutnost hipokalijemije i hipomagnezijemije može dodatno pojačati taj učinak.
English: The efficacy results are summarised in Table 3.
Croatian: Rezultati djelotvornosti sažeti su u Tablici 3.
English: If you are not able to take the medicine as your doctor prescribed or you feel you do not need it anymore, contact your doctor right away.
Croatian: Ako ne možete uzeti lijek onako kako Vam je liječnik propisao ili ako osjećate da Vam više nije potreban, odmah se obratite svom liječniku.
English: The medicines listed here may not be the only ones that could interact with Bosulif.
Croatian: Ovdje navedeni lijekovi možda nisu jedini koji mogu imati uzajamno djelovanje s lijekom Bosulif.
English: You should inform your doctor if you are taking medicines containing active substances such as those listed below:
Croatian: Morate obavijestiti svog liječnika ako uzimate lijekove koji sadrže djelatne tvari poput ovih navedenih u nastavku:
English: What Bosulif is and what it is used for
Croatian: Što je Bosulif i za što se koristi
English: Includes patients (N) who attained or maintained MCyR.
Croatian: Uključuje bolesnike (N) koji su dostigli ili održali MCyR.
English: Bosutinib did not have effects on respiratory functions.
Croatian: Bosutinib nije imao učinaka na respiratorne funkcije.
English: Swallow the tablet(s) whole with water.
Croatian: Progutajte tabletu(tablete) cijelu/cijele s vodom.
English: Do not stop taking Bosulif unless your doctor tells you to do so.
Croatian: Nemojte prestati uzimati Bosulif ako Vam to nije rekao liječnik.
English: Pfizer Manufacturing Deutschland GmbH Betriebsstӓtte Freiburg Mooswaldallee 1
Croatian: Pfizer Manufacturing Deutschland GmbH Betriebsstätte Freiburg Mooswaldallee 1
English: Date of first authorisation: 27 March 2013 Date of latest renewal: 18 February 2019
Croatian: Datum posljednje obnove odobrenja: 18. veljače 2019.
English: Other medicines and Bosulif
Croatian: Drugi lijekovi i Bosulif
English: Including patients (N) who received at least 1 dose of bosutinib.
Croatian: Uključujući bolesnike (N) koji su primili najmanje 1 dozu bosutiniba.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription, vitamins, and herbal medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući lijekove dobivene bez recepta, vitamine i biljne lijekove.
English: Resume treatment with bosutinib at the same dose if recovery occurs within 2 weeks.
Croatian: Nastaviti liječenje bosutinibom istom dozom ako dođe do oporavka unutar 2 tjedna.
English: This medicine has been given “conditional approval”.
Croatian: Ovom lijeku izdano je ‘uvjetno odobrenje'.
English: Frequency categories are defined as: very common ( 1/10), common ( 1/100 to < 1/10), uncommon ( 1/1,000 to < 1/100), rare ( 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Croatian: Kategorije učestalosti su definirane na sljedeći način: vrlo često ( 1/10), često ( 1/100 i < 1/10), manje često ( 1/1000 i < 1/100), rijetko ( 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Ph-positive CML is a cancer of the blood which makes the body produce too many of a specific type of white blood cell called granulocytes.
Croatian: Ph-pozitivna KML je rak krvi kod kojeg tijelo stvara previše određenih bijelih krvnih stanica koje se zovu granulociti.
English: Some medicines can affect the levels of Bosulif in your body.
Croatian: Određeni lijekovi mogu utjecati na razine lijeka Bosulif u Vašem tijelu.
English: The safety analyses included data from an ongoing extension study.
Croatian: Analize podataka o sigurnosti primjene uključivale su podatke dobivene tijekom nastavka ispitivanja koje još traje.
English: - Do not use this medicine if you notice that the pack is damaged or shows signs of tampering.
Croatian: - Ovaj lijek se ne smije upotrijebiti ako primijetite da je pakiranje oštećeno ili pokazuje znakove nedozvoljenog rukovanja.
English: The relationship between the observed effects and medicinal product treatment were inconclusive.
Croatian: Odnos između opaženih učinaka i liječenja lijekom nije bilo moguće utvrditi sa sigurnošću.
English: Bosulif is indicated for the treatment of adult patients with:
Croatian: Bosulif je indiciran u liječenju odraslih bolesnika s:
English: No specific dose recommendation is necessary in the elderly.
Croatian: Nisu potrebne specifične preporuke za doze u starijih bolesnika.
English: If you experience dizziness, have blurred vision or feel unusually tired, do not drive or operate machines until these side effects have gone away.
Croatian: Ako imate omaglicu, zamagljeni vid ili se osjećate neuobičajeno umorno, nemojte voziti ni upravljati strojevima sve dok te nuspojave ne prođu.
English: Your doctor may change the dose of these medicines, change the dose of Bosulif, or switch you to a different medicine.
Croatian: Vaš liječnik može promijeniti dozu navedenih lijekova, promijeniti dozu lijeka Bosulif ili Vas prebaciti na drugačiji lijek.
English: This is because Bosulif could cause hepatitis B to become active again, which can be fatal in some cases.
Croatian: To je potrebno jer Bosulif može uzrokovati ponovnu aktivaciju hepatitisa B što u nekim slučajevima može rezultirati smrtnim ishodom.
English: You must immediately contact your doctor if you experience any of those serious side effects (see also section 2 “What you need to know before you take Bosulif”):
Croatian: Ako primijetite bilo koju od sljedećih ozbiljnih nuspojava morate odmah obavijestiti Vašeg liječnika (pogledajte također dio 2 "Što morate znati prije nego počnete uzimati Bosulif"):
English: Clinical signs of toxicity included foecal changes and were associated with decreased food consumption and body weight loss which occasionally led to death or elective euthanasia.
Croatian: Klinički znakovi toksičnosti uključivali su promjene fecesa i bili su povezani sa smanjenim unosom hrane i gubitkom tjelesne težine koji su ponekad doveli do smrti ili elektivne eutanazije.
English: Bosutinib was highly bound to human plasma proteins in vitro (94%) and ex vivo in healthy subjects (96%), and binding was not concentration-dependent.
Croatian: Bosutinib se izrazito vezivao za ljudske proteine plazme in vitro (94%) i ex vivo u zdravih ispitanika (96%), a vezivanje nije ovisilo o koncentraciji.
English: In particular, you should ask your doctor if you want to use a medicine containing domperidone for the treatment of nausea and/or vomiting.
Croatian: Naročito to morate pitati svog liječnika ako želite koristiti lijek koji sadrži domperidon za liječenje mučnine i/ili povraćanja.
English: Complete blood counts should be performed weekly for the first month and then monthly thereafter, or as clinically indicated.
Croatian: Tjedno se mora kontrolirati kompletnu krvnu sliku tijekom prvog mjeseca, zatim jedanput mjesečno nakon toga ili kad god je to klinički indicirano.
English: This is called tumour lysis syndrome and can cause kidney failure and heart problems within 48 hours of the first dose of Bosulif.
Croatian: To se naziva sindrom lize tumora i može uzrokovati zatajenje bubrega i probleme sa srcem unutar 48 sati od prve doze lijeka Bosulif.
English: One patient with the E255V mutation previously treated with nilotinib achieved CHR as best response.
Croatian: Jedan bolesnik s mutacijom E255V, prethodno liječen nilotinibom, postigao je CHR kao najbolji odgovor.
English: Hepatitis B reactivation
Croatian: Ponovna aktivacija hepatitisa B
English: Bosulif with food and drink Do not take Bosulif with grapefruit or grapefruit juice, as it may increase the risk of side effects.
Croatian: Bosulif s hranom i pićem Nemojte uzimati Bosulif s grejpom ili sokom od grejpa, jer to može povećati rizik od nuspojava.
English: An effect on male fertility cannot be excluded (see section 4.6).
Croatian: Učinak na plodnost u mužjaka ne može se isključiti (vidjeti dio 4.6).
English: Return to chronic phase (RCP)=disappearance of features defining accelerated or blast phases but still in chronic phase.
Croatian: Povratak u kroničnu fazu =nestanak obilježja koja određuju ubrzanu ili blastičnu fazu, ali još uvijek u kroničnoj fazi.
English: If you faint (loss of consciousness) or have an irregular heartbeat while taking Bosulif, tell your doctor immediately, as this may be a sign of a serious heart condition.
Croatian: Ako se onesvijestite (gubitak svijesti) ili imate nepravilne otkucaje srca dok uzimate Bosulif, odmah obavijestite liječnika jer to može biti znak ozbiljnog stanja srca.
English: Based on non-clinical findings, bosutinib has the potential to impair reproductive function and fertility in humans (see section 5.3).
Croatian: Na temelju nekliničkih rezultata, bosutinib ima potencijal oštećenja reproduktivne funkcije i plodnosti u ljudi (vidjeti dio 5.3).
English: What Bosulif is and what it is used for What you need to know before you take Bosulif How to take Bosulif
Croatian: Što je Bosulif i za što se koristi Što morate znati prije nego počnete uzimati Bosulif Kako uzimati Bosulif
English: Bosutinib belongs to a pharmacological class of medicinal products known as kinase inhibitors.
Croatian: Bosutinib pripada farmakološkoj skupini lijekova poznatih kao inhibitori kinaze.
English: Your doctor may adjust the dose using the 100 mg tablets depending upon your medical conditions, upon your response to treatment and/or on any side effect you may experience.
Croatian: Vaš liječnik može prilagoditi dozu primjenom tableta od 100 mg ovisno o Vašem zdravstvenom stanju, o Vašem odgovoru na liječenje i/ili o bilo kojoj nuspojavi.
English: Bosutinib should be permanently discontinued in patients who experience a severe skin reaction during treatment.
Croatian: Bosutinib treba trajno prekinuti u bolesnika koji su iskusili tešku kožnu reakciju tijekom liječenja.
English: - if you have heart problems.
Croatian: - ako imate problema sa srcem.
English: Absorption was relatively slow, with a median time-to-peak concentration (tmax) reached after 6 hours.
Croatian: Apsorpcija je bila relativno spora, a medijan vremena do vršne koncentracije (tmax) dostignut je nakon 6 sati.
English: Excretion of unchanged bosutinib in urine was low with approximately 1% of the dose in both healthy subjects and those with advanced malignant solid tumours.
Croatian: Ekskrecija nepromijenjenog bosutiniba u urinu je bila niska, približno 1% doze, kako u zdravih ispitanika tako i u onih s uznapredovalim malignim solidnim tumorima.
English: Experience with bosutinib overdose in clinical studies was limited to isolated cases.
Croatian: Iskustvo s predoziranjem bosutinibom u kliničkim ispitivanjima ograničeno je na izolirane slučajeve.
English: Table 5 - Efficacy results in previously treated patients with chronic and advanced phase CML*
Croatian: Tablica 5 - Rezultati djelotvornosti u prethodno liječenih bolesnika s KML-om u kroničnoj i uznapredovaloj fazi*
English: Number (%) of subjects with MMR
Croatian: Broj (%) ispitanika s MMR-om
English: Therefore, clinical activity in patients with these mutations is not expected.
Croatian: Stoga se u bolesnicima s tim mutacijama ne očekuje klinička aktivnost.
English: In addition, the patient should be advised that vomiting or diarrhoea may reduce the efficacy of oral contraceptives by preventing full absorption.
Croatian: Nadalje, bolesnicu je nužno upozoriti da povraćanje ili proljev mogu smanjiti učinkovitost oralne kontracepcije sprječavajući potpunu apsorpciju.
English: If recovery takes longer than 4 weeks, discontinuation of bosutinib should be considered.
Croatian: Ako oporavak traje dulje od 4 tjedna, mora se razmisliti o prekidu liječenja bosutinibom.
English: Serum lipase
Croatian: Serumska lipaza
English: Elevation in serum lipase has been observed.
Croatian: Zapažen je porast serumske lipaze.