FrancophonIA/ELRC3.0 huggingface dataset:
English: In post-marketing experience, angioedema or angioedema-like reactions have been reported when aliskiren was co-administered with ACEIs and/or ARBs (see section 4.8).
Croatian: Nakon stavljanja lijeka u promet bili su prijavljeni angioedem ili angioedemu slične reakcije kada se aliskiren primjenjivao istodobno sa ACEI-ima i/ili ARB-ima (vidjeti dio 4.8).
English: If co-medication with an agent affecting the level of serum potassium is considered necessary, routine monitoring of potassium levels would be advisable.
Croatian: Ako se istodobna primjena s lijekom koji utječe na razinu kalija u serumu smatra nužnom, savjetuje se rutinsko praćenje razina kalija.
English: In some patients with compromised renal function (dehydrated patients or elderly patients) aliskiren and hydrochlorothiazide given concomitantly with NSAIDs may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Croatian: U nekih bolesnika s kompromitiranom funkcijom bubrega (dehidrirani bolesnici ili stariji bolesnici) aliskiren i hidroklorotiazid dani istodobno s NSAIL-ovima mogu rezultirati daljnjim pogoršanjem funkcije bubrega, uključujući moguće akutno zatajenje bubrega, koje je obično reverzibilno.
English: Rasilez HCT contains wheat starch.
Croatian: Rasilez HCT sadrži pšenični škrob.
English: Rasilez HCT is indicated as substitution therapy in patients adequately controlled with aliskiren and hydrochlorothiazide, given concurrently, at the same dose level as in the combination.
Croatian: Rasilez HCT je indiciran kao zamjenska terapija u bolesnika odgovarajuće kontroliranih istodobnom primjenom aliskirena i hidroklorotiazida u istim dozama koje sadrži fiksna kombinacija.
English: After the first 52 week extension study, eligible male and female paediatric patients aged 6 to 17 years with primary or secondary hypertension, were enrolled in a 52 to 104 week off-therapy noninterventional observational extension study designed to evaluate the LT growth and development, through height and weight measurement, with added neurocognitive and renal function evaluations as follow-up measures performed only in patients with secondary hypertension (19 patients: 9 previously treated with aliskiren and 10 previously treated with enalapril).
Croatian: Nakon prva 52 tjedna nastavka ispitivanja, podobni muški i ženski pedijatrijski bolesnici u dobi od 6 do 17 godina s primarnom ili sekundarnom hipertenzijom, bili su uključeni u 52 do 104 tjedna neintervencijskog opservacijskog nastavka ispitivanja bez terapije oblikovanog za procjenu dugoročnog rasta i razvoja, mjerenjem težine i visine, s dodatnim procjenama neurokognitivne i bubrežne funkcije kao mjera praćenja provedenih samo u bolesnika sa sekundarnom hipertenzijom (19 bolesnika: 9 prethodno liječenih aliskirenom i 10 prethodno liječenih enalaprilom).
English: Nervous system disorders Rare
Croatian: Poremećaji živčanog sustava Rijetko
English: The pharmacokinetics of aliskiren were evaluated in patients with end stage renal disease receiving haemodialysis.
Croatian: Farmakokinteika aliskirena bila je ocjenjivana u bolesnika na hemodijalizi u završnom stadiju bubrežne bolesti.
English: Treatment with Rasilez HCT should only start after correction of hypokalaemia and any coexisting hypomagnesaemia.
Croatian: Liječenje Rasilez HCT-om smije se započeti tek nakon što se korigira hipokalijemija i svaka prateća hipomagnezijemija.
English: Administration of fruit juice with aliskiren resulted in a decrease in AUC and Cmax of aliskiren.
Croatian: Uzimanje voćnog soka s aliskirenom rezultiralo je smanjenjem AUC-a i Cmax-a aliskirena.
English: In some patients with compromised renal function (dehydrated patients or elderly patients) aliskiren given concomitantly with NSAIDs may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Croatian: U nekih bolesnika s kompromitiranom funkcijom bubrega (dehidrirani bolesnici ili stariji bolesnici) aliskiren dan istodobno s NSAIL-ima može rezultirati daljnjim pogoršanjem funkcije bubrega, uključujući moguće akutno zatajenje bubrega, koje je obično reverzibilno.
English: • Severe allergic reaction (anaphylactic reaction), allergic reactions (hypersensitivity) and angioedema (the symptoms of which can include difficulties in breathing or swallowing, rash, itching, hives or swelling of the face, hands and feet, eyes, lips and/or tongue, dizziness).
Croatian: • Teška alergijska reakcija (anafilaktička reakcija), alergijske reakcije (preosjetljivost) i angioedem (čiji simptomi mogu uključivati teškoće pri disanju ili gutanju, osip, svrbež, koprivnjača ili oticanje lica, šaka i stopala, očiju, usnica i/ili jezika, omaglica). (rijetko: mogu se javiti u do 1 na 1000 osoba)
English: • Kidney problems including acute renal failure (severely decreased urine output)
Croatian: • problemi s bubrezima, uključujući akutno zatajenje bubrega (jako smanjeno izlučivanje mokraće)
English: Astheniah, pyrexiah
Croatian: Astenijah, pireksijah
English: MDR1/Mdr1a/1b (P-gp) was found to be the major efflux system involved in intestinal absorption and biliary excretion of aliskiren in preclinical studies (see section 5.2).
Croatian: U pretkliničkim ispitivanjima je otkriveno da MDR1/Mdr1a/1b (P-gp) predstavlja glavni efluksni sustav uključen u intestinalnu apsorpciju aliskirena i izlučivanje aliskirena putem žuči (vidjeti dio 5.2).
English: When administered in hypertensive patients with markedly elevated blood pressure (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg), Rasilez HCT in doses from 150 mg/12.5 mg to 300 mg/25 mg administered without up-titration from monotherapy demonstrated significantly greater systolic/diastolic blood pressure control rates (< 140/90 mmHg) as compared to the respective monotherapies.
Croatian: Kada se primjenjivao u hipertenzivnih bolesnika sa značajno povišenim krvnim tlakom (sistolički krvni tlak ≥160 mmHg i/ili dijastolički krvni tlak ≥100 mmHg), Rasilez HCT u dozama od 150 mg/12,5 mg do 300 mg/25 mg primijenjen bez prethodne titracije monoterapijom doveo je do značajno većih stopa kontrole sistoličkog/dijastoličkog krvnog tlaka (<140/90 mmHg) u usporedbi s odgovarajućim monoterapijama.
English: • Dizziness with spinning sensation
Croatian: • omaglica uz osjećaj vrtnje
English: Coadministration of grapefruit juice with aliskiren 150 mg resulted in a 61% decrease in aliskiren AUC and co-administration with aliskiren 300 mg resulted in a 38% decrease in aliskiren AUC.
Croatian: Istodobna primjena soka od grejpa s aliskirenom150 mg rezultirala je smanjenjem AUC-a aliskirena za 61%, dok je istodobna primjena s aliskirenom 300 mg rezultirala smanjenjem AUC-a aliskirena za 38%.
English: Therefore, caution should be used if coadmnistering with any other hypertensive agents
Croatian: Stoga je potreban oprez prilikom istodobne uporabe s bilo kojim drugim antihipertenzivnim lijekovima.
English: Inducers of P-gp (St. John's wort, rifampicin) might therefore decrease the bioavailability of aliskiren.
Croatian: Induktori P-gp-a (gospina trava, rifampicin) stoga bi mogli smanjiti bioraspoloživost aliskirena.
English: Conversely, increases in serum potassium have been observed with aliskiren in post-marketing experience and these may be exacerbated by concomitant use of other agents acting on the RAAS or by non-steroidal anti-inflammatory drugs (NSAIDs).
Croatian: Suprotno tome, nakon stavljanja aliskirena u promet opažena su povišenja kalija u serumu, što može biti pogoršano istodobnom primjenom drugih lijekova koji djeluju na RAAS ili nesteroidnih prouupalnih lijekova (NSAIL-a).
English: Rasilez HCT is indicated in patients whose blood pressure is not adequately controlled on aliskiren or hydrochlorothiazide used alone.
Croatian: Rasilez HCT je indiciran u bolesnika čiji krvni tlak nije odgovarajuće kontroliran primjenom samo aliskirena ili samo hidroklorotiazida.
English: Rasilez HCT is contraindicated in patients with severe hepatic impairment (see section 4.3).
Croatian: Rasilez HCT-a je kontraindiciran u bolesnika s teškim oštećenjem jetrene funkcije (vidjeti dio 4.3).
English: Multi-packs containing 280 (20 packs of 14) tablets.
Croatian: Višestruka pakiranja sadrže 280 (20 pakiranja od 14) tableta.
English: However, the use of aliskiren is not recommended in patients with severe renal impairment (see section 4.4).
Croatian: Međutim, primjena aliskirena ne preporučuje se u bolesnika s teškim oštećenjem bubrežne funkcije (vidjeti dio 4.4).
English: Rasilez HCT is contraindicated in patients with severe hepatic impairment and should be used with caution in patients with mild to moderate hepatic impairment or progressive liver disease.
Croatian: Rasilez HCT je kontraindiciran u bolesnika s teškim oštećenjem jetrene funkcije, a oprez je potreban i prilikom njegove primjene u bolesnika s blagim do umjerenim oštećenjem jetrene funkcije ili progresivnom jetrenom bolešću.
English: Single-packs (perforated unit dose blister) containing 56 x 1 tablets.
Croatian: Pojedinačna pakiranja (perforirani blister s jediničnim dozama) sadrže 56 x 1 tabletu.
English: In post-marketing experience, cases of angioedema or angioedema-like reactions have been reported when aliskiren was co-administered with ACEIs and/or ARBs.
Croatian: Nakon stavljanja lijeka u promet bili su prijavljeni slučajevi angioedema ili angioedemu sličnih reakcija kada se aliskiren istodobno primjenjivao sa ACEI-ima i/ili ARB-ovima.
English: − Anuria.
Croatian: − Anurija.
English: • Low level of magnesium in the blood
Croatian: • niska razina magnezija u krvi
English: In this population, Rasilez HCT 150 mg/12.5 mg to 300 mg/25 mg provided dose-dependent systolic/diastolic blood pressure reduction from 20.6/12.4 mmHg to 24.8/14.5 mmHg, which were significantly superior to the respective monotherapies.
Croatian: U ovoj populaciji, Rasilez HCT 150 mg/12,5 mg do 300 mg/25 mg osigurao je smanjenje o dozi ovisnog sistoličkog/dijastoličkog krvnog tlaka od 20,6/12,4 mmHg do 24,8/14,5 mmHg, što je bilo značajno bolje od odgovarajućih monoterapija.
English: There was a greater LS mean increase from Baseline in height after 104 weeks (at LT Visit 19 [Week 156], secondary hypertension patients) compared to the increase observed after 52 weeks (at LT Visit 18 [Week 104], primary hypertension patients), which is expected in these growing paediatric patients.
Croatian: Nakon 104 tjedna (u 19. posjetu u sklopu procjene dugoročne sigurnosti [156. tjedan], bolesnici sa sekundarnom hipertenzijom) došlo je do većeg povećanja srednje vrijednosti (dobivene metodom najmanjih kvadrata) u odnosu na početne vrijednosti za visinu u usporedbi s povećanjem opaženim nakon 52 tjedna (u 18. posjetu u sklopu procjene dugoročne sigurnosti [104. tjedan], bolesnici s primarnom hipertenzijom), što je očekivano kod tih pedijatrijskih bolesnika koji su u rastu.
English: Rasilez HCT is contraindicated in patients with hypercalcaemia and should only be used after correction of any preexisting hypercalcaemia.
Croatian: Rasilez HCT je kontraindiciran u bolesnika s hiperkalcijemijom te se može primjenjivati tek nakon korigiranja već postojeće hiperkalcemije.
English: It can also be used in patients whose blood pressure is adequately controlled with aliskiren and hydrochlorothiazide taken as separate tablets, to replace the same doses of the two active substances.
Croatian: Također se može koristiti kao zamjena u bolesnika čiji je krvni tlak odgovarajuće kontroliran istodobnom primjenom aliskirena i hidroklortiazida kao odvojenih tableta u istim dozama kao u kombinaciji.
English: There was a statistically significant increased incidence of syncope with the combination of aliskiren and enalapril compared to enalapril in the overall population (4.2% versus 2.8%; RR 1.51, 95% CI 1.11-2.05) and in the subgroups NYHA I/II overall (4.8% versus 3.0%; RR 1.62, 95% CI 1.14-2.29).
Croatian: Postojala je statistički značajno povećana incidencija sinkopa kod kombinacije aliskirena i enalaprila u usporedbi s enalaprilom u ukupnoj populaciji (4,2% naspram 2,8%; RR (omjer rizika) 1,51; interval pouzdanosti od 95% 1,11-2,05) i u podskupinama NYHA I/II sveukupno (4,8% naspram 3,0%, RR 1,62, interval pouzdanosti od 95% 1,14-2,29).
English: If photosensitivity reaction occurs during treatment with Rasilez HCT, it is recommended to stop the treatment.
Croatian: Ako se tijekom liječenja Rasilez HCT-om javi fotosenzitivna reakcija, preporučuje se prekinuti liječenje.
English: Cutaneous lupus erythematosus-like reactionsh, reactivation of cutaneous lupus erythematosush, vasculitis necrotising and toxic epidermal necrolysish
Croatian: Reakcije slične kožnom eritematoznom lupusu h, reaktivacija kožnog eritematoznog lupusa h, nekrotizirajući vaskulitis i toksična epidermalna nekrolizah
English: However, the significance of the non-inferiority testing was not maintained when the analysis was performed on the per-protocol set in which the least square mean change in msSBP from baseline was -7.84 mmHg with aliskiren and -9.04 mmHg with enalapril.
Croatian: Međutim, značajnost za testiranje neinferiornosti nije se održala kada je analiza obavljena u skupu podataka za bolesnike koji su liječenje završili po planu ispitivanja u kojem je srednja vrijednost dobivena metodom najmanjih kvadrata za promjenu sistoličkog krvnog tlaka u sjedećem položaju u odnosu na početak iznosila -7,84 mmHg za aliskiren i -9,04 mmHg za enalapril.
English: In a study in 183 randomised patients with severe hypertension (mean sitting diastolic blood pressure ≥ 105 and < 120 mmHg), aliskiren treatment regimen with optional addition of hydrochlorothiazide 25 mg was shown to be safe and efficacious in reducing blood pressure.
Croatian: U ispitivanju u 183 randomizirana bolesnika s teškom hipertenzijom (srednja vrijednost dijastoličkog krvnog tlaka u sjedećem položaju ≥105 i <120 mmHg), liječenje aliskirenom uz mogućnost dodavanja hidroklorotiazida u dozi od 25 mg je bilo sigurno i djelotvorno u sniženju krvnog tlaka.
English: - if you experience a decrease in vision or eye pain.
Croatian: - ako nakon sunčanja dobijete kožnu reakciju kao što je osip. - ako osjetite smanjenje vida ili bol u oku.
English: In this study, Rasilez HCT in doses from 150 mg/12.5 mg to 300 mg/25 mg produced dose-dependent blood pressure reductions (systolic/diastolic) from 17.6/11.9 mmHg to 21.2/14.3 mmHg, respectively, compared to 7.5/6.9 mmHg with placebo.
Croatian: U ovom je ispitivanju Rasilez HCT primijenjen u dozama od 150 mg/12,5 mg do 300 mg/25 mg doveo do sniženja krvnog tlaka ovisnog o dozi (sistolički/dijastolički) od 17,6/11,9 mmHg do 21,2/14,3 mmHg u usporedbi s placebom 7,5/6,9 mmHg.
English: Results from a mechanistic study showed that the MDR1 (P-gp) gene expression in juvenile rats was significantly lower when compared to adult rats.
Croatian: Rezultati ispitivanja mehanizma pokazali su da je ekspresija gena MDR1 (P-gp) u mladih štakora bila značajno niža u usporedbi s odraslim štakorima.Čini se da se povećana izloženost aliskirenu u mladih štakora pripisuje uglavnom manjku sazrijevanja P-gp-a u gastrointestinalnom traktu.
English: When administered with atorvastatin (80 mg), steady-state aliskiren (300 mg) AUC and Cmax increased by 50%.
Croatian: Kada je primijenjen s atrovastatinom (80 mg), AUC i Cmax aliskirena (300 mg) u stanju dinamičke ravnoteže se povećao za 50%.
English: In patients with mild to moderate renal impairment, a 3-fold increase in hydrochlorothiazide AUC has been observed.
Croatian: U bolesnika s blagim do umjerenim oštećenjem bubrežne funkcije opaženo je da se vrijednost AUC-a hidroklorotiazida povećala 3 puta.
English: Multi-packs (perforated unit dose blister) containing 98 (2 packs of 49 x 1) tablets.
Croatian: Višestruka pakiranja (perforirani blister s jediničnim dozama) sadrže 98 (2 pakiranja od 49 x 1) tableta.
English: Non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors), acetylsalicylic acid and non-selective NSAIDs
Croatian: Nesteroidni protuupalni lijekovi (NSAIL-i), uključujući selektivne inhibitore ciklooksigenaze-2 (COX-2 inhibitore), acetilsalicilatna kiselina i neselektivni NSAIL-i NSAIL-i mogu smanjiti antihipertenzivni učinak aliskirena.
English: - if you have renal artery stenosis (narrowing of the blood vessels to one or both kidneys).
Croatian: - ako imate stenozu bubrežne arterije (suženje krvnih žila u jednome ili oba bubrega).
English: In addition, measures necessary to maintain patent airways should be provided.
Croatian: Osim toga, potrebno je omogućiti mjere neophodne za održavanje prohodnosti dišnih puteva bolesnika.
English: You should avoid taking this medicine together with fruit juice and/or drinks containing plant extracts (including herbal teas).
Croatian: Izbjegavajte uzimanje ovog lijeka zajedno s voćnim sokomi/ili napitcima koji sadrže biljne ekstrakte (uključujući biljne čajeve).
English: • Inflammation of blood vessels with symptoms such as rash, purplish-red spots, fever (vasculitis)
Croatian: • upala krvnih žila sa simptomima poput osipa, ljubičaste mrlje na koži, vrućica (vaskulitis)
English: The incidence of adjudicated stroke was not significantly different between the aliskiren and enalapril groups (4.4% versus 4.0%; HR 1.12, 95% CI 0.848, 1.485) or between the combination and enalapril groups (3.7% versus 4.0%; HR 0.93, 95% CI 0.697, 1.251).
Croatian: Incidencija utvrđenog moždanog udara nije bila značajno različita između skupine na aliskirenu i one na enalaprilu (4,4% naspram 4,0%; omjer hazarda 1,12; interval pouzdanosti od 95% 0,848, 1,485) ili između skupine na kombinaciji odnosno enalaprilu (3,7% naspram 4,0%; omjer hazarda 0,93; interval pouzdanosti od 95% 0,697; 1,251).
English: For the combination of aliskiren and enalapril there were statistically significant differences in the rate of angina unstable compared to enalapril.
Croatian: Postojala je statistički značajna razlika u stopi nestabilne angine za kombinaciju aliskirena i enalaprila u odnosu na enalapril.
English: In patients with severe renal impairment an 8-fold increase in AUC has been observed.
Croatian: U bolesnika s teškim oštećenjem bubrežne funkcije uočeno je da su se vrijednosti AUC-a povećale 8 puta.
English: • Severe skin disease that causes rash, red skin, blistering of the lips, eyes or mouth, skin peeling,
Croatian: • teška kožna bolest koja uzrokuje osip, crvenu kožu, stvaranje mjehurića na usnicama, očima ili ustima, ljuštenje kože, vrućica (multiformni eritem)
English: How to take Rasilez HCT
Croatian: Kako uzimati Rasilez HCT
English: 280 film-coated tablets (20 packs of 14)
Croatian: 280 filmom obloženih tableta (20 pakiranja od 14)
English: Impotenceh
Croatian: Impotencijah
English: − The concomitant use of Rasilez HCT with an angiotensin converting enzyme inhibitors (ACEI)
Croatian: Istodobna primjena Rasilez HCT-a s inhibitorima angiotenzin-konvertirajućeg enzima(engl.
English: If you take more Rasilez HCT than you should If you have accidentally taken too many tablets of this medicine, talk to a doctor immediately.
Croatian: Ako ste slučajno uzeli previše tableta ovog lijeka, odmah se obratite svom liječniku.
English: MDR1/Mdr1a/1b (P-gp) was found to be the major efflux system involved in intestinal absorption and biliary excretion of aliskiren in pre-clinical studies.
Croatian: U pretkliničkim ispitivanjima otkriveno je da je MDR1/Mdr1a/1b (P-gp) glavni efluksni sustav uključen u intestinalnu apsorpciju i izlučivanje aliskirena putem žuči.
English: PHARMACEUTICAL FORM AND CONTENTS Multipack: 98 (2 packs of 49) film-coated tablets Multipack: 280 (20 packs of 14) film-coated tablets Multipack: 90 (3 packs of 30) film-coated tablets
Croatian: OBLIK I SADRŽAJ Višestruko pakiranje: 98 (2 pakiranja od 49) filmom obloženih tableta Višestruko pakiranje: 280 (20 pakiranja od 14) filmom obloženih tableta Višestruko pakiranje: 90 (3 pakiranja od 30) filmom obloženih tableta
English: • Pale skin, tiredness, breathlessness, dark-coloured urine (haemolytic anaemia)
Croatian: • blijeda koža, umor, nedostatak zraka, tamno obojana mokraća (hemolitička anemija)
English: No initial dose adjustment of Rasilez HCT is required in elderly patients.
Croatian: U starijih bolesnika nije potrebna prilagodba početne doze Rasilez HCT-a.
English: Hydrochlorothiazide may reduce the response to pressor amines such as noradrenaline.
Croatian: Vazopresorni amini (npr. noradrenalin, adrenalin) Hidroklorotiazid može smanjiti odgovor na vazopresorne amine kao što je noradrenalin.
English: The change in plasma levels of aliskiren in the presence of ketoconazole or verapamil is expected to be within the range that would be achieved if the dose of aliskiren were doubled; aliskiren doses of up to 600 mg, or twice the highest recommended therapeutic dose, have been found to be well tolerated in controlled clinical studies.
Croatian: Očekuje se da bi promjena u razinama aliskirena u plazmi u prisutnosti ketokonazola ili verapamila bila unutar raspona koji bi se postigao kada bi se doza aliskirena udvostručila.
English: The adverse reactions previously reported with one of the individual components of Rasilez HCT (aliskiren and hydrochlorothiazide) and included in the tabulated list of adverse reactions may occur with Rasilez HCT.
Croatian: Nuspojave već prije prijavljene u bolesnika s jednom od komponenti lijeka Rasilez HCT (aliskiren i hidroklorotiazid) te uključene u tablični popis nuspojava, mogu se pojaviti i s uzimanjem Rasilez HCT-a.
English: Contents of the pack and other information What Rasilez HCT contains - The active substances are aliskiren and hydrocholorothiazide.
Croatian: Što Rasilez HCT sadrži - Djelatne tvari su aliskiren i hidroklorotiazid.
English: RAAS blockers (angiotensin converting enzyme inhibitors or angiotensin receptor blockers) (see section 4.8).
Croatian: angiotensin converting enzyme inhibitors, ACEI) ili blokatorima receptora angiotenzina II
English: • High level of calcium in the blood
Croatian: • visoka razina kalcija u krvi
English: Treatment with Rasilez HCT had an overall incidence of adverse experiences at doses up to 300 mg/25 mg similar to placebo.
Croatian: Liječenje Rasilez HCT-om u dozama do 300 mg/25 mg rezultiralo je ukupnom incidencijom nuspojava sličnom placebu.
English: In post-marketing experience, renal dysfunction, and cases of acute renal failure have been reported in patients at risk (see section 4.4).
Croatian: Nakon stavljanja lijeka u promet u rizičnih bolesnika prijavljena je disfunkcija bubrega i slučajevi akutnog zatajenja bubrega (vidjeti dio 4.4).
English: - medicines that may reduce the amount of potassium in your blood, such as diuretics (water tablets), corticosteroids, laxatives, carbenoxolone, amphotericin or penicillin G. - medicines that may induce “torsades de pointes” (irregular heart beat), such as antiarrhythmics (medicines used to treat heart problems) and some antipsychotics.
Croatian: To uključuje nadomjestke kalija ili zamjene za sol koje sadrže kalij, lijekove koji štede kalij i heparin. - lijekove koji mogu smanjiti količinu kalija u Vašoj krvi, kao što su diuretici (tablete za mokrenje), kortikosteroidi, laksativi, karbenoksolon, amfotericin ili penicilin G. - lijekove koji mogu izazvati „torsades de pointes“ (nepravilni otkucaji srca), kao što su antiaritmici (lijekovi kojima se liječe srčani problemi) i neki antipsihotici. - lijekove koji mogu smanjiti količinu natrija u Vašoj krvi, kao što su antidepresivi, antipsihotici,
English: Thiazide-induced hypokalaemia or hypomagnesaemia may occur as undesirable effects, favouring the onset of digitalis-induced cardiac arrhythmias.
Croatian: Hipokalijemija ili hipomagnezijemija izazvane tiazidima mogu se javiti kao nuspojave koje pogoduju nastupu srčanih aritmija izazvanih digitalisom.
English: The adverse reactions listed in the table above, which are marked with the reference “h”, have been reported in patients treated with thiazide diuretics alone, including hydrochlorothiazide.
Croatian: U bolesnika koji su liječeni samo tiazidnim diureticima, uključujući hidroklorotiazid, prijavljene su nuspojave opisane u tablici iznad, u kojoj su označene referencom “h”.