FrancophonIA/ELRC3.0 huggingface dataset:
English: • Periodic safety update reports (PSURs)
Croatian: • Periodička izvješća o neškodljivosti (PSUR-evi)
English: Initiate treatment with 50 micrograms once daily as a subcutaneous injection in the thigh (alternate thigh every day).
Croatian: Započnite liječenje sa 50 mikrograma jedanput dnevno supkutanom injekcijom u bedro (pri čemu se bedro u koje se injekcija daje mijenja svakog dana).
English: • Before attaching a new needle to your Natpar pen, check that the solution is clear and colourless.
Croatian: • Prije pričvršćivanja nove igle na Natpar brizgalicu, provjeriti je li otopina bistra i bezbojna.
English: Clinical studies of Natpar did not include sufficient numbers of subjects aged 65 and over to determine whether response in these subjects is different from younger subjects.
Croatian: Klinička ispitivanja lijeka Natpar nisu uključila dovoljan broj ispitanika u dobi od 65 i više godina kako bi se utvrdilo je li odgovor u tih ispitanika različit od onog u mlađih ispitanika.
English: • Email Shire at medinfoEMEA@shire.com.
Croatian: • obratite se e-poštom tvrtki Shire na adresu: medinfoEMEA@shire.com,
English: In vitro and in vivo studies demonstrated that the clearance of Natpar is primarily a hepatic process with a lesser role played by the kidneys.
Croatian: In vitro i in vivo ispitivanja pokazala su da je klirens lijeka Natpar primarno hepatički proces, u kojem bubrezi imaju manju ulogu.
English: Natpar should be used with caution in patients with severe renal or hepatic disease because they have not been evaluated in clinical trials.
Croatian: Natpar treba primjenjivati uz oprez u bolesnika s teškom bolesti bubrega ili jetre jer nisu procijenjeni u kliničkim ispitivanjima.
English: You only need to do this one time for each new pen.
Croatian: Ovaj postupak morate provesti samo jedanput, i to kada uzimate novu brizgalicu.
English: • Refer to the following Frequently Asked Questions.
Croatian: • pogledajte odgovore na česta pitanja, navedene ispod.
English: If post-dose serum calcium remains >ULN, oral calcium supplementation should be further reduced or discontinued (see also adjustment table under Initiating Natpar).
Croatian: Ako kalcij u serumu nakon doze ostane >GGN, treba dodatno smanjiti ili prekinuti primjenu peroralno uzimanih nadomjestaka kalcija (vidjeti također tablicu prilagodbe doze pod Započinjanje primjene lijeka Natpar).
English: Adjust dose of active vitamin D or calcium supplement or both based on serum calcium value and clinical assessment (i.e., signs and symptoms of hypocalcaemia or hypercalcaemia).
Croatian: Prilagodite dozu aktivnog vitamina D ili nadomjestka kalcija, ili i jednog i drugog, na temelju vrijednosti kalcija u serumu i kliničke procjene (tj. znakova i simptoma hipokalcemije ili hiperkalcemije).
English: • Attach a new disposable needle every day before you use the pre-filled pen and discard the used needles after one use (See Step 17: “Discard your used needles”).
Croatian: • Svaki dan prije uporabe napunjene brizgalice stavite na nju novu jednokratnu iglu, a iskorištene igle bacite nakon jedne upotrebe (pogledajte 17. korak, „Bacite iskorištene igle“).
English: Repeat steps 4 and 5 until target pre-dose serum calcium concentration is within the range of 2.0-2.25 mmol/L, active vitamin D has been discontinued and calcium supplementation is sufficient to meet daily requirements.
Croatian: Ponovite korake 4 i 5 dok ciljne koncentracije kalcija u serumu prije doze ne budu unutar raspona od 2,0-2,25 mmol/l, primjena aktivnog vitamina D bude prekinuta i nadomjestak kalcija dostatan za zadovoljenje dnevnih potreba.
English: Hypocalcaemia, a common clinical manifestation of hypoparathyroidism, was reported in clinical trials with Natpar.
Croatian: Hipokalcemija, uobičajena klinička manifestacija hipoparatiroidizma, prijavljena je u kliničkim ispitivanjima s lijekom Natpar.
English: Natpar has no or negligible influence on the ability to drive and use machines.
Croatian: Natpar ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: This medicinal product contains less than 1 mmol (23 mg) sodium per dose.
Croatian: Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po dozi, tj. zanemarive količine natrija.
English: • allergic reactions (hypersensitivity), such as: swelling of the face, lips, mouth, or tongue;
Croatian: • alergijske reakcije (preosjetljivost) kao što su: oticanje lica, usana, usta ili jezika; nedostatak zraka; svrbež; osip; koprivnjača
English: Natpar is a hormone replacement for adults with under-active parathyroid glands, a condition known as ‘hypoparathyroidism'.
Croatian: Natpar je nadomjestak hormona u odraslih sa smanjenom aktivnosti paratiroidnih žlijezda, stanjem poznatim kao ‘hipoparatiroidizam'.
English: Hypercalcaemia commonly occurred during the titration period, during which doses of oral calcium, active vitamin D, and Natpar were being adjusted.
Croatian: Hiperkalcemija se obično pojavila tijekom razdoblja titracije, u kojem su prilagođavane doze oralno uzimanog kalcija, aktivnog vitamina D i lijeka Natpar.
English: Hypoparathyroidism is a disease caused by low levels of parathyroid hormone, which is produced by the parathyroid glands in the neck.
Croatian: Hipoparatiroidizam je bolest prouzročena niskim razinama paratiroidnog hormona, koji proizvode paratiroidne žlijezde u vratu.
English: If signs or symptoms of a serious hypersensitivity reaction occur, treatment with Natpar should be discontinued and hypersensitivity reaction should be treated according to the standard of care.
Croatian: Ako se pojave znakovi ili simptomi ozbiljne reakcije preosjetljivosti, potrebno je prekinuti liječenje lijekom Natpar i primijeniti standardno liječenje reakcije preosjetljivosti.
English: Important: It is recommended to switch thighs every day for your injection site.
Croatian: Važno: Preporučuje se da lijek svaki dan injicirate u drugo bedro.
English: A pharmacokinetic study in non-hypoparathyroidism subjects was conducted in 6 men and 6 women with moderate hepatic impairment (Child-Pugh Classification of 7-9 [Grade B]) as compared with a matched group of 12 subjects with normal hepatic function.
Croatian: Jedno farmakokinetičko ispitivanje u kojem su sudjelovali ispitanici koji ne boluju od hipoparatiroidizma provedeno je u 6 muškaraca i 6 žena s umjereno oštećenom funkcijom jetre (Child-Pughova klasifikacija od 7-9 [razred B] i uspoređena s odgovarajućom skupinom od 12 ispitanika s normalnom funkcijom jetre.
English: PTH exerts its action via cell-surface parathyroid hormone receptors, present in bone, kidney and nerve tissue.
Croatian: PTH djeluje putem receptora za paratiroidni hormon na površini stanica koji su prisutni u kostima, bubrezima i živčanom tkivu.
English: After a single injection of parathyroid hormone (rDNA), the mean serum total calcium reached its peak level between 10 and 12 hours.
Croatian: Nakon pojedinačne injekcije paratiroidnog hormona (rDNK), srednja ukupna vrijednost kalcija u serumu dosegla je vršnu razinu u razdoblju između 10 i 12 sati nakon injekcije.
English: Exposure to PTH as measured by AUC0-last and baseline-corrected AUC0-last was approximately 3.9% and 2.5%, respectively, higher than that observed for subjects with normal renal function.
Croatian: Izloženost PTH-u mjerena uz pomoć AUC0-last i vrijednosti AUC0-last korigirane za početnu vrijednost bila je oko 3,9%, odnosno 2,5% viša nego ona uočena u ispitanika s normalnom funkcijom bubrega.
English: 6 • To mix the medicine, slowly screw down the cartridge in a clockwise direction (See “Before” figure) until you hear and feel a “click” and the cartridge will no longer turn (See “After” figure).
Croatian: 6. • Da biste izmiješali lijek, polako zakrećite uložak u smjeru kazaljke na satu (pogledajte sliku „Prije“) sve dok ne čujete i ne osjetite „klik“ i dok se uložak više ne može okretati (pogledajte sliku „Poslije“).
English: A responder was defined using a composite primary efficacy endpoint of at least a 50% reduction from the baseline active vitamin D dose AND at least a 50% reduction from the baseline oral calcium AND an albumin-corrected total serum calcium concentration maintained or normalised compared with the baseline value (≥1.875 mmol/L) and did not exceed the upper limit of the laboratory normal range.
Croatian: Ispitanik koji je odgovorio na terapiju definiran je pomoću kompozitne primarne mjere ishoda djelotvornosti koja se sastojala od najmanje 50% smanjenja doze aktivnog vitamina D u odnosu na početnu vrijednost TE najmanje 50% smanjenja peroralno uzimanog kalcija u odnosu na početnu vrijednost TE ukupne koncentracije kalcija u serumu korigirane za albumin koja je održavana ili normalizirana u usporedbi s početnom vrijednošću (≥ 1,875 mmol/l) i koja nije premašila gornju granicu laboratorijskog normalnog raspona.
English: Serum 1,25-(OH)2D increases following a single dose of Natpar to maximum levels at about 12 hours with a return to near baseline levels by 24 hours.
Croatian: Vrijednost 1,25-(OH)2D u serumu povećava se nakon pojedinačne doze lijeka Natpar do maksimalnih razina nakon otprilike 12 sati, što se vraća na razine blizu početnih vrijednosti nakon 24 sata.
English: The calcium-raising effect of Natpar may diminish over time in some patients.
Croatian: Učinak povišenja kalcija koji ima lijek Natpar može se s vremenom smanjiti u nekih bolesnika.
English: Do not use this medicine after the expiry date which is stated on the pen and carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na brizgalici i kutiji iza oznake EXP.
English: In the clinical studies, these reactions were generally mild to moderate in severity and transient, and were managed with adjustments of Natpar, calcium and/or active vitamin D doses (see sections 4.4 and 5.1).
Croatian: U kliničkim ispitivanjima te su reakcije općenito bile blage do umjerene težine i prolazne, a rješavane su prilagođavanjem doza lijeka Natpar, kalcija i/ili aktivnog vitamina D (vidjeti dijelove 4.4 i 5.1).
English: *These side effects may be related to high level of calcium in your blood.
Croatian: *Te nuspojave mogu biti povezane s visokom razinom kalcija u krvi.
English: *Signs and symptoms potentially associated with hypercalcaemia that were observed in the clinical trials.
Croatian: *Znakovi i simptomi koji mogu biti povezani s hiperkalcemijom koji su uočeni u kliničkim ispitivanjima.
English: When you first start using Natpar, a trainer will guide you through how to mix your Natpar pen and give your injections.
Croatian: Kada tek počnete primjenjivati Natpar, osoba koja Vas tome podučava pokazat će Vam kako izmiješati Natpar brizgalicu i kako injicirati lijek.
English: • Press the blue button down all the way until you hear or feel 2 clicks, and continue holding the button down.
Croatian: • Pritisnite plavi gumb do kraja - sve dok ne začujete ili ne osjetite 2 klika, a zatim ga nastavite držati tako pritisnutim.
English: PHARMACEUTICAL FORM AND CONTENTS Powder and solvent for solution for injection 2 pre-filled pens
Croatian: OBLIK I SADRŽAJ Prašak i otapalo za otopinu za injekciju 2 napunjene brizgalice
English: • Store in a refrigerator (2°C to 8°C).
Croatian: • Čuvati u hladnjaku (2°C - 8°C).
English: Calcium, vitamin D, or Natpar doses may need to be reduced if post-dose hypercalcaemia is observed, even if pre-dose calcium concentrations are acceptable (see section 4.2).
Croatian: Možda će biti potrebno smanjiti doze kalcija, vitamina D, ili lijeka Natpar ako se nakon primjene doze uoči hiperkalcemija, čak i ako su koncentracije kalcija prije doze prihvatljive (vidjeti dio 4.2).
English: In addition, 87% (73/84) of patients treated with Natpar showed a ≥50% reduction in oral active vitamin D versus 45% (18/40) in the placebo group.
Croatian: Uz to, 87% (73/84) bolesnika liječenih lijekom Natpar pokazalo je ≥50% smanjenja peroralno uzimanog aktivnog vitamina D, naspram 45% (18/40) u skupini koja je primala placebo.
English: You will need the following supplies for your injection:
Croatian: Za injiciranje lijeka potreban Vam je sljedeći pribor:
English: If you experience any of these side effects, contact your doctor right away.
Croatian: Ako imate bilo koju od sljedećih nuspojava, odmah kontaktirajte svog liječnika.
English: Make sure you do not unscrew the needle
Croatian: Pazite da ne odvijete iglu.
English: Continue to push the blue button until you hear a ‘hard' click and the blue button stays in. Make sure that the blue button stays down.
Croatian: Nastavite pritiskati plavi gumb dok ne čujete „čvrsti“ klik i plavi gumb ostane uvučen.
English: The maximum mean increases of serum calcium, which occurred at 12 hours, were approximately 0.125 mmol/L and 0.175 mmol/L with the 50 micrograms and 100 micrograms dose, respectively.
Croatian: Maksimalna srednja povećanja kalcija u serumu, koja su nastupila nakon 12 sati, bila su otprilike 0,125 mmol/l i 0,175 mmol/l pri dozi od 50 mikrograma, odnosno 100 mikrograma.
English: In the placebo-controlled study in adults with hypoparathyroidism, the incidence of anti-parathyroid hormone (PTH) antibodies was 8.8% (3/34) and 5.9% (1/17) in patients who received subcutaneous administration of 50 to 100 micrograms Natpar or placebo once daily for 24 weeks, respectively.
Croatian: U placebom kontroliranom ispitivanju u kojem su sudjelovali odrasli ispitanici s hipoparatiroidizmom, incidencija pojave antitijela na paratiroidni hormon (PTH) bila je 8,8% (3/34) i 5,9% (1/17) u bolesnika koji su supkutanom injekcijom primali 50 do 100 mikrograma lijeka Natpar, odnosno placeba, jedanput dnevno tijekom 24 tjedna.
English: • Check that the yellow dose counter lines up with the black dot (See Figure E).
Croatian: • Provjerite je li žuta oznaka brojača doza u ravnini s crnom točkom (pogledajte sliku E).
English: In the placebo-controlled study, 9.5% (8/84) Natpar-treated patients and 15% (6/40) placebo-treated patients experienced an injection site reaction, all of which were mild or moderate in severity.
Croatian: U placebom kontroliranom ispitivanju, 9,5% (8/84) bolesnika liječenih lijekom Natpar i 15% (6/40) bolesnika koji su primali placebo imalo je reakcije na mjestu injiciranja, od kojih su sve bile blage do umjerene težine.
English: Natpar has not been studied in patients with urolithiasis.
Croatian: Natpar nije ispitivan u bolesnika s urolitijazom.
English: Tighten the needle and make sure that the needle is on straight and the threads are lined up.
Croatian: Zategnite iglu i provjerite je li pričvršćena ravno i sjeda li uložak pravilno u utore.
English: • If needed, clean your pen by wiping the outside with a cloth dampened with water.
Croatian: • Ako je potrebno, očistite brizgalicu tako što ćete je izvana obrisati krpicom koju ste navlažili vodom.
English: Metabolism and nutrition disorders hypercalcaemia, hypocalcaemia hypomagnesaemia tetany
Croatian: Poremećaji metabolizma i prehrane hiperkalcemija, hipokalcemija hipomagnezemija tetanus
English: If needed, clean the pen by wiping the outside with a cloth dampened with water.
Croatian: Ako je potrebno, brizgalicu očistite tako što ćete je izvana obrisati krpicom koju ste navlažili vodom.
English: This means that there is more evidence to come about this medicine.
Croatian: To znači da će biti dostavljeno još dodatnih podataka o ovome lijeku.
English: Pharmacokinetics following a single 100 micrograms subcutaneous dose of Natpar was evaluated in 16 non-impaired subjects (creatinine clearance (CLcr) >80 mL/min) and 16 subjects with renal impairment.
Croatian: Farmakokinetički podaci nakon jedne supkutano primijenjene doze lijeka Natpar od 100 mikrograma su ocijenjeni u 16 ispitanika kod kojih nije postojalo oštećenje funkcije bubrega (klirens kreatinina (CLcr) >80 ml/min) i u 16 ispitanika s oštećenom funkcijom bubrega.
English: Parathyroid hormone (rDNA) was evaluated in an open-label PK/PD study in which 7 patients with hypoparathyroidism received single subcutaneous doses of 50 and 100 micrograms with a 7-day washout interval between doses.
Croatian: Paratiroidni hormon (rDNK) procijenjen je u otvorenom ispitivanju FK/FD u kojem je 7 bolesnika s hipoparatiroidizmom primilo pojedinačne supkutane doze od 50 i 100 mikrograma uz 7-dnevno razdoblje ispiranja lijeka između doza.
English: The mean percent change from baseline in oral calcium was -51.8% (SD 44.6) in subjects receiving Natpar compared to 6.5% (SD 38.5) in the placebo group (p<0.001).
Croatian: Srednji postotak promjene od početne vrijednosti peroralno uzimanog kalcija bio je -51,8% (SD 44,6) u ispitanika koji su primali Natpar, u usporedbi sa 6,5% (SD 38,5) u skupini koja je primala placebo (p<0,001).
English: Overdose can cause hypercalcaemia, the symptoms of which may include heart palpitations, ECG changes, hypotension, nausea, vomiting, dizziness and headache.
Croatian: Predoziranje može izazvati hiperkalcemiju, čiji simptomi mogu uključivati palpitacije srca, promjene u nalazima EKG-a, hipotenziju, mučninu, povraćanje, omaglicu i glavobolju.
English: Musculoskeletal and connective tissue disorders arthralgia*, muscle spasms muscle twitching musculoskeletal pain myalgia
Croatian: Poremećaji mišićnokoštanog sustava i vezivnog tkiva artralgija*, spazam mišića trzanje mišića mišićno-koštana bol mialgija
English: Suggested adjustments to Natpar, active vitamin D and calcium supplements based on serum calcium levels are provided below:
Croatian: Preporučene prilagodbe lijeka Natpar, aktivnog vitamina D i nadomjestka kalcija na temelju razina kalcija u serumu su sljedeće:
English: Always store your pen in the refrigerator between 2°C to 8°C.
Croatian: Brizgalicu uvijek čuvajte u hladnjaku, na temperaturi između 2 °C i 8 °C.
English: Measure pre-dose serum calcium concentration within 2 to 5 days.
Croatian: Mjerite koncentraciju kalcija u serumu prije primjene doze unutar razdoblja od 2 do 5 dana.
English: The response of serum calcium concentration to administration of Natpar should be monitored at intervals to detect this and the diagnosis of tachyphylaxis considered.
Croatian: Potrebno je u intervalima pratiti odgovor koncentracije kalcija u serumu na primjenu lijeka Natpar kako bi se to uočilo i razmotrila dijagnoza tahifilaksije.
English: Natpar should be used with caution in patients with active or recent urolithiasis because of the potential to exacerbate this condition.
Croatian: Natpar treba primjenjivati uz oprez u bolesnika s aktivnom ili nedavnom urolitijazom jer može dovesti do egzacerbacije tog stanja.
English: At randomisation, active forms of vitamin D were reduced by 50% and patients were allocated to Natpar 50 micrograms daily or placebo.
Croatian: D smanjeni su za 50% i bolesnici su dodijeljeni za primanje 50 mikrograma lijeka Natpar dnevno, ili za primanje placeba.
English: If you are treated with Natpar, you may have side effects related to low or high levels of calcium in your blood (see section 4 for these side effects).
Croatian: Ako se liječite lijekom Natpar, možete imati nuspojave vezane uz niske ili visoke razine kalcija u krvi (vidjeti dio 4 za te nuspojave).
English: Natpar is given as a subcutaneous (under the skin) injection every day, using a pen to help you inject your medicine.
Croatian: Natpar se daje kao potkožna (supkutana) injekcija svakog dana, brizgalicom koja će Vam olakšati injiciranje lijeka.
English: In these studies, Natpar was self-administered, with daily doses ranging from 25 to 100 micrograms per subcutaneous injection.
Croatian: Ispitanici su u tim ispitivanjima sami primjenjivali lijek Natpar u dnevnim dozama u rasponu od 25 do 100 mikrograma po supkutanoj injekciji.
English: Name and address of the manufacturer(s) of the biological active substance(s)
Croatian: Naziv i adresa proizvođača biološke(ih) djelatne(ih) tvari
English: The mean maximum concentration (Cmax) of PTH following 100 micrograms parathyroid hormone (rDNA) in subjects with mild-to-moderate renal impairment (CLcr 30 to 80 mL/min) was approximately 23% higher than that observed in subjects with normal renal function.
Croatian: Srednja maksimalna koncentracija (Cmax) PTH-a nakon davanja 100 mikrograma paratiroidnog hormona (rDNK) u ispitanika s blago do umjereno oštećenom funkcijom bubrega (CLcr 30 do 80 ml/min) bila je oko 23% veća od one uočene u ispitanika s normalnom funkcijom bubrega.
English: Treatment with Natpar produces a decrease in urinary calcium excretion by 13 and 23% (50 and 100 microgram dose, respectively) to a nadir in the 3 to 6 hour time point, which returns to pre-dosing levels by 16 to 24 hours.
Croatian: Liječenje lijekom Natpar dovodi do smanjenja izlučivanja kalcija u urinu za 13 i 23% (pri dozi od 50, odnosno 100 mikrograma) do najniže vrijednosti u vremenskoj točki između 3 i 6 sati, što se vraća na razine prije doziranja nakon 16 do 24 sata.
English: Red pen label.
Croatian: Crvena naljepnica na brizgalici.
English: In the case of a missed dose, Natpar must be administered as soon as reasonably feasible and additional exogenous sources of calcium and/or active vitamin D must be taken based on symptoms of hypocalcaemia.
Croatian: U slučaju propuštanja doze, Natpar se mora primijeniti što je prije razumno moguće, te se moraju uvesti dodatni egzogeni izvori kalcija i/ili aktivnog vitamina D na temelju simptoma hipokalcemije.
English: Do not dispose of your sharps disposal container in your household trash.
Croatian: Nemojte baciti spremnik za oštre predmete u kućni otpad.
English: Pack size: Carton containing 2 pre-filled pens.
Croatian: Veličina pakiranja: Kutija koja sadrži 2 napunjene brizgalice.
English: 5 • If the remaining liquid is colourless and today's date is before the “Discard On” date (See Medicine Tracker), go to Step 6.
Croatian: 5. • Ako je preostala tekućina bezbojna i današnji datum prethodi datumu navedenom pored „Baciti“ (pogledajte Dnevnik zamjene brizgalice), prijeđite na 6. korak.
English: Signs and symptoms potentially associated with hypocalcaemia that were observed in the clinical trials.
Croatian: Znakovi i simptomi koji mogu biti povezani s hipokalcemijom koji su uočeni u kliničkim ispitivanjima.
English: Do not recycle your used sharps disposal container.
Croatian: Nemojte reciklirati spremnik za oštre predmete.
English: In a multi-centre clinical trial, albumin-corrected serum calcium (ACSC) values 6-10 hours post-dose were on average 0.25 mmol/L higher than the pre-dose values, with a maximum increase observed of 0.7 mmol/L.
Croatian: U multicentričnom kliničkom ispitivanju, vrijednosti kalcija u serumu korigiranih za albumin 6-10 sati nakon doze bile su u prosjeku 0,25 mmol/l više nego vrijednosti prije doze, s uočenim maksimalnim povećanjem od 0,7 mmol/l.
English: • mannitol
Croatian: • manitol
English: The following potentially serious side effects can occur when using Natpar:
Croatian: Tijekom primjene lijeka Natpar mogu se pojaviti sljedeće potencijalno ozbiljne nuspojave:
English: At the end of treatment, 46/84 (54.8%) patients treated with Natpar achieved the primary endpoint versus 1/40 (2.5%) with placebo (p<0.001).
Croatian: Na kraju liječenja, 46/84 (54,8%) bolesnika koji su primali Natpar postiglo je primarni ishod, naspram 1/40 (2,5%) bolesnika koji su primali placebo (p<0,001).
English: Natpar dosage adjustments after the initiation period Serum calcium concentration must be monitored during titration (see section 4.4).
Croatian: Prilagođavanje doze lijeka Natpar nakon početnog razdoblja Tijekom titracije mora se pratiti koncentraciju kalcija u serumu (vidjeti dio 4.4).
English: The needle must be pointing down at all times until after the injection so that the air stays away from the needle.
Croatian: Za vrijeme injiciranja lijeka, i sve dok ne završite s injiciranjem, igla mora biti okrenuta prema dolje, kako bi zrak ostao udaljen od igle.
English: Do not use your pen on or after the “Discard On” date.
Croatian: Nemojte upotrijebiti brizgalicu ako je pored „Baciti“ naveden današnji ili kasniji datum.
English: Adjust first
Croatian: Prva prilagodba
English: What you need to know before you use Natpar 3.
Croatian: Što morate znati prije nego počnete primjenjivati Natpar 3. Kako primjenjivati Natpar 4. Moguće nuspojave