FrancophonIA/ELRC3.0 huggingface dataset:
English: Therefore, maintaining lamivudine therapy despite emergence of M184V mutation should only be considered in cases where no other active NRTIs are available.
Croatian: Stoga nastavak liječenja lamivudinom, unatoč pojavi mutacije M184V, treba razmotriti samo u slučajevima kad nisu dostupni drugi aktivni NRTI-i.
English: It cannot be excluded that abacavir may increase the risk of having a heart attack.
Croatian: Ne može se isključiti da abakavir može povisiti rizik od nastanka srčanog udara.
English: It is recommended that mothers infected by HIV do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.
Croatian: Preporučuje se da majke zaražene HIV-om ni u kojem slučaju ne doje kako bi se izbjegao prijenos
English: Some people taking Trizivir develop other conditions, which can be serious.
Croatian: Neki ljudi koji uzimaju Trizivir razvijaju i druga stanja koja mogu biti ozbiljna.
English: Therefore the following should be adhered to:
Croatian: Stoga se uvijek treba pridržavati sljedećih smjernica:
English: The incidence of neutropenia was also increased in those patients whose neutrophil counts, haemoglobin levels and serum vitamin B12 levels were low at the start of zidovudine therapy.
Croatian: Incidencija neutropenije bila je također povećana u onih bolesnika čiji su broj neutrofila, razina hemoglobina i razina vitamina B12 u serumu bili niski na početku liječenja zidovudinom.
English: Your doctor may need to monitor you while you are taking Trizivir.
Croatian: Liječnik bi Vas trebao nadzirati dok uzimate Trizivir.
English: Keep in touch with your doctor, and do not stop taking Trizivir without your doctor's advice.
Croatian: Ostanite u redovitom kontaktu sa svojim liječnikom i nemojte prestati uzimati Trizivir bez prethodnog savjetovanja s njim.
English: • lactic acidosis (excess lactic acid in the blood ; see the next section, ‘Other possible side effects of
Croatian: • laktacidoza (nakupljanje mliječne kiseline u krvi, pogledajte sljedeći odjeljak 'Ostale moguće nuspojave na Trizivir')
English: It is important to take Trizivir regularly, because if you take it at irregular intervals it may not continue to work against the HIV infection, and you may be more likely to have a hypersensitivity reaction.
Croatian: Važno je da Trizivir uzimate redovito jer ako ga neredovito uzimate tada možda više neće djelovati protiv infekcije HIV-om te se može povećati rizik od reakcije preosjetljivosti.
English: Do not store above 30°C
Croatian: Ne čuvati na temperaturi iznad 30°C
English: • pentamidine or atovaquone, to treat parasitic infections such as Pneumocystis jirovecii pneumonia (often referred to as PCP)
Croatian: • pentamidin ili atovakuon, za liječenje infekcija poput upale pluća uzrokovane s Pneumocystis jirovecii (koja se često naziva PCP)
English: The true extent of CNS penetration of lamivudine and its relationship with any clinical efficacy is unknown.
Croatian: Stvarni opseg prodiranja lamivudina u SŽS i povezanost s kliničkom djelotvornošću nije poznat.
English: If overdose occurs the patient should be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Croatian: Ako dođe do predoziranja, potrebno je nadzirati bolesnika kako bi se uočili znakovi toksičnosti (vidjeti dio 4.8), kao i primijeniti uobičajene mjere suportivnog liječenja ako se za to ukaže potreba.
English: Treatment with zidovudine should be discontinued in the setting of symptomatic hyperlactatemia and metabolic/lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.
Croatian: Liječenje zidovudinom mora se prekinuti u slučaju simptomatske hiperlaktatemije i metaboličke/laktacidoze, progresivne hepatomegalije ili rapidnog povišenja razine aminotransferaza.
English: When prescribing Trizivir, action should be taken to try to minimize all modifiable risk factors (e.g. smoking, hypertension, and hyperlipidaemia).
Croatian: Stoga kada se propisuje Trizivir, potrebno je poduzeti mjere kako bi se smanjili svi potencijalni čimbenici rizika (npr. pušenje, hipertenzija i hiperlipidemija).
English: (organic cation transporter inhibition)
Croatian: (inhibicija transportera organskog kationa)
English: Some people taking combination therapy for HIV develop a condition called osteonecrosis.
Croatian: Neki bolesnici koji uzimaju kombiniranu terapiju za HIV razvijaju stanje koje nazivamo osteonekroza.
English: Nucleoside and nucleotide analogues may impact mitochondrial function to a variable degree, which is most pronounced with stavudine, didanosine and zidovudine.
Croatian: Analozi nukleozida i nukleotida mogu u različitom stupnju utjecati na funkciju mitohondrija, a taj je utjecaj najizraženiji uz stavudin, didanozin i zidovudin.
English: Abacavir and its metabolites are excreted into the milk of lactating rats.
Croatian: Abakavir i njegovi metaboliti izlučuju se u mlijeko ženki štakora.
English: You need to know about important signs and symptoms to look out for while you are taking Trizivir.
Croatian: Zbog toga morate biti upoznati s važnim znakovima i simptomima na koje treba obratiti pozornost prilikom uzimanja lijeka Trizivir.
English: • HLA-B*5701 status must always be documented prior to initiating therapy.
Croatian: • Status HLA-B*5701 mora se uvijek dokumentirati prije početka liječenja.
English: Food decreased the rate of absorption of Trizivir (slight decrease Cmax (mean 18 - 32 %) and increase tmax (approximately 1 hour), but not the extent of absorption (AUC0-∞).
Croatian: Hrana je smanjivala brzinu apsorpcije lijeka Trizivir (blago smanjenje Cmax (srednja vrijednost 18 - 32%) i povećavala vrijednost tmax (oko 1 sat), ali nije djelovala na raspon apsorpcije (AUC0-∞).
English: Methadone dosage adjustment unlikely in majority of patients; occasionally methadone re-titration may be required.
Croatian: Potreba za prilagođavanjem doze metadona je malo vjerojatna kod većine bolesnika, možda će biti potrebna povremena retitracija metadona.
English: In one study, by the US National Cancer Institute, zidovudine was administered at maximum tolerated doses to pregnant mice from day 12 to 18 of gestation.
Croatian: U jednom ispitivanju koje je proveo američki Nacionalni institut za rak zidovudin je primijenjen u najvećoj podnošljivoj dozi skotnim ženkama od 12. do 18. dana gestacije.
English: Glaxo Operations UK Ltd (trading as Glaxo Wellcome Operations), Priory Street, Ware, Hertfordshire, SG 12 0DJ, United Kingdom.
Croatian: Glaxo Operations UK Ltd (posluje kao Glaxo Wellcome Operations), Priory Street, Ware, Hertfordshire, SG 12 0DJ, Velika Britanija.
English: Treatment with Trizivir often causes a loss of fat from legs, arms and face (lipoatrophy).
Croatian: Liječenje lijekom Trizivir često uzrokuje gubitak masnog tkiva u nogama, rukama i licu (lipoatrofija).
English: A subsequent intravaginal carcinogenicity study confirmed the hypothesis that the vaginal tumours were the result of long term local exposure of the rodent vaginal epithelium to high concentrations of unmetabolised zidovudine in urine.
Croatian: Daljnje ispitivanje intravaginalne karcinogeneze potvrdila su hipotezu da su vaginalni tumori posljedica dugotrajne lokalne izloženosti vaginalnog epitela glodavaca visokim koncentracijama nemetaboliziranog zidovudina u urinu.
English: The primary pathways of metabolism in man are by alcohol dehydrogenase and by glucuronidation to produce the 5'-carboxylic acid and 5'-glucuronide which account for about 66 % of the dose excreted in the urine.
Croatian: Glavni putevi metabolizma u čovjeka odvijaju se pomoću alkohol dehidrogenaze i glukuronidacije te se pri tome stvaraju 5'-karboksilna kiselina i 5'-glukuronid koji čine oko 66 % doze koja se izlučuju u urinu.
English: Zidovudine AUC ↑80% (UGT inhibition) ANTIHISTAMINES (HISTAMINE H2 RECEPTOR ANTAGONISTS) Ranitidine/Abacavir
Croatian: zidovudin AUC ↑80% (UGT inhibicija) ANTIHISTAMINICI (ANTAGANOSTI HISTAMINSKIH H2 RECEPTORA) ranitidin/abakavir
English: The anaemia may necessitate transfusions.
Croatian: Možda će biti nužne transfuzije zbog anemije.
English: Viral resistance to abacavir develops relatively slowly in vitro, requiring multiple mutations for a clinically relevant increase in EC50 over wild-type virus.
Croatian: Rezistencija virusa na abakavir relativno se sporo razvija in vitro jer zahtjeva brojne mutacije za klinički značajan porast u EC50 u odnosu na divlji soj virusa.
English: Rare: anorexia, lactic acidosis in the absence of hypoxaemia
Croatian: Rijetko: anoreksija, laktacidoza u odsutnosti hipoksemije
English: • changes in the colour of your nails, your skin, or the skin inside your mouth
Croatian: • promjene boje noktiju, kože, sluznice u ustima
English: Other medicines and Trizivir
Croatian: Drugi lijekovi i Trizivir
English: Overall, the virologic suppression with this triple nucleoside regimen could be inferior to that obtained with other multitherapies notably including boosted Protease inhibitors or non nucleoside reverse transcriptase inhibitors, therefore the use of Trizivir should only be considered under special circumstances (e.g. co-infection with tuberculosis).
Croatian: Ukupno gledajući, supresija virusa pomoću ovog režima s tri nukleozida mogla bi biti inferiorna onoj koja se postiže pomoću drugih kombiniranih terapija, posebno onih koje uključuju pojačane inhibitore proteaze ili nenukleozidne inhibitore reverzne transkriptaze, te stoga korištenje lijeka Trizivir treba razmotriti samo u posebnim okolnostima (npr. u slučajevima istovremene infekcije tuberkulozom).
English: In addition, two transplacental carcinogenicity studies have been conducted in mice.
Croatian: Dodatno, u miševa su provedena dva ispitivanja transplacentarne karcinogenosti.
English: The clinically relevant toxicological effects of these three medicinal products are anaemia, neutropenia and leucopenia.
Croatian: Klinički značajni toksikološki učinci ova tri lijeka su anemija, neutropenija i leukopenija.
English: If concomitant therapy with Trizivir and any of these medicinal products is necessary then extra care should be taken in monitoring renal function and haematological parameters and, if required, the dosage of one or more agents should be reduced.
Croatian: Ako je istovremena terapija s lijekom Trizivir i bilo kojim od navedenih lijekova neophodna, potreban je poseban nadzor nad renalnom funkcijom i hematološkim parametrima te, ako je potrebno, smanjenje doze jednog ili više lijekova.
English: There is no evidence from clinical studies that abacavir is hepatotoxic.
Croatian: Nema dokaza iz kliničkih ispitivanja koji bi upućivali da je abakavir hepatotoksičan.
English: • clarithromycin, an antibiotic If you are taking clarithromycin, take your dose at least 2 hours before or after you take your Trizivir.
Croatian: Ako uzimate klaritromicin, lijek uzmite najmanje 2 sata prije ili nakon što ste uzeli Trizivir.
English: Dose reduction or cessation of therapy may become necessary (see section 4.4).
Croatian: Možda će biti nužno smanjiti dozu ili prekinuti terapiju (vidjeti dio 4.4).
English: Interaction studies have only been performed in adults.
Croatian: Studije koje su proučavale interakciju provođene su isključivo među odraslom populacijom.
English: It is important to read the information on the other side of this leaflet under ‘Other possible side effects of Trizivir'.
Croatian: Stoga je važno pročitati informacije navedene u ovom dijelu ispod pod naslovom 'Ostale moguće nuspojave lijeka Trizivir'.
English: • chest pain; disease of the heart muscle (cardiomyopathy)
Croatian: • bol u prsima, bolest srčanog mišića (kardiomiopatija)
English: You should immediately contact your doctor if you think you are having a hypersensitivity reaction to Trizivir.
Croatian: Odmah obavijestite Vašeg liječnika ako smatrate da imate reakciju preosjetljivosti na Trizivir.
English: Therefore, there is little potential for interactions with antiretroviral protease inhibitors, nonnucleosides and other medicinal products metabolised by major P450 enzymes.
Croatian: Stoga postoji mala mogućnost za interakcije lijeka s antiretrovirusnim inhibitorima proteaze, nenukleozidima te drugim lijekovima koji se metaboliziraju putem glavnih P450 enzima.
English: Patients co-infected with hepatitis B or C virus
Croatian: Bolesnici s istodobnom infekcijom virusom hepatitisa B ili C
English: People may be more likely to get this condition:
Croatian: Stoga bolesnici mogu biti skloniji razviti to stanje:
English: As a general rule, when deciding to use antiretroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account.
Croatian: Opće pravilo je da se kod odluke o primjeni antiretrovirusnih lijekova za liječenje infekcije HIV-a u trudnica i posljedično tome smanjenju rizika vertikalnog prijenosa HIV-a na novorođenčad trebaju uzeti u obzir i podaci dobiveni na životinjama kao i klinička iskustva na trudnicama.
English: There is no experience of overdose with Trizivir.
Croatian: Nema iskustva s predoziranjem lijekom Trizivir.
English: High doses of trimethoprim/ sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis have not been studied and should be avoided.
Croatian: Visoke doze trimetoprima/sulfametoksazola za liječenje pneumonije uzrokovane s Pneumocystis jirovecii i toksoplazmoze nisu do sada proučavane te bi ih trebalo izbjegavati.
English: All of these belong to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
Croatian: One pripadaju skupini antiretrovirusnih lijekova nazvanih inhibitorima reverzne transkriptaze analoga nukleozida (NRTI).
English: Virologic failure (HIV RNA >200 copies/ml)
Croatian: Nedostatak virološkog odgovora (HIV RNA >200 kopija/ml)
English: If you have any further questions ask your doctor or pharmacist.
Croatian: - Ako imate dodatnih pitanja, obratite se svom liječniku ili ljekarniku.
English: When you are being treated for HIV, it can be hard to tell whether a symptom is a side effect of Trizivir or other medicines you are taking, or an effect of the HIV infection itself.
Croatian: Za vrijeme liječenja infekcije HIV-om ponekad je teško razlučiti je li simptom nuspojava lijeka Trizivir ili nekog drugog lijeka koji uzimate ili je to učinak same infekcije HIV-om.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Croatian: Iako se smatra da je etiologija multifaktorijalna (uključujući primjenu kortikosteroida, uživanje alkohola, tešku imunosupresiju, visoki indeks tjelesne mase), opisani su slučajevi osteonekroze, osobito u bolesnika s uznapredovalom HIV bolešću i/ili dugotrajnom izloženošću kombiniranom antiretrovirusnom liječenju.
English: As well as the side effects listed below for Trizivir, other conditions can develop during treatment.
Croatian: Kao i niže navedene nuspojave za Trizivir, i druga stanja mogu se razviti za vrijeme terapije.
English: Insufficient data to recommend dosage adjustment.
Croatian: Nedostatni podaci na osnovu kojih bi se preporučila prilagodba doze.
English: People with advanced HIV infection (AIDS) have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Croatian: Bolesnici s uznapredovalom HIV infekcijom (AIDS) imaju oslabljen imunološki sustav te su skloniji razvoju ozbiljnih infekcija (oportunističke infekcije).
English: Blue-green capsule-shaped film-coated tablets engraved with “GX LL1” on one side.
Croatian: Plavo-zelene filmom obložene tablete u obliku kapsule s utisnutom oznakom “GX LL1” na jednoj strani.
English: Intravenous studies with abacavir, lamivudine and zidovudine showed that the mean apparent volume of distribution is 0.8, 1.3 and 1.6 l/kg respectively.
Croatian: Intravenska ispitivanja s abakavirom, lamivudinom i zidovudinom pokazala su da prividni srednji volumen distribucije iznosi oko 0,8, 1,3 i 1,6 l/kg, prema redoslijedu navođenja.
English: This fat loss, which is most evident in the face, limbs and buttocks, may not be reversible when switching to a zidovudine-free regimen.
Croatian: Taj gubitak masnog tkiva koji je najočitiji na licu, udovima i stražnjici, ne mora biti reverzibilan kad se prijeđe na režim liječenja bez zidovudina.
English: TRIZIVIR TABLETS ALERT CARD (blister and bottle pack)
Croatian: TRIZIVIR TABLETE - KARTICA S UPOZORENJEM (blister pakiranje i bočica) 1. STRANA
English: Trizivir tablets are available in opaque white PCTFE/PVC-Al blister packs or child-resistant foil PVC/PCTFE/PVC-Al/Paper blister packs containing 60 tablets, or child resistant HDPE bottles containing 60 tablets.
Croatian: Trizivir tablete su dostupne u neprozirnim bijelim PCTFE/PVC-Al blister pakiranjima ili PVC/PCTFE/PVC-Al/papir blister pakiranjima sa sigurnosnom folijom za djecu koji sadrže 60 tableta ili HDPE bočicama sa sigurnosnim zatvaračem za djecu koje sadrže 60 tableta.
English: Methadone and Trizivir
Croatian: Metadon i Trizivir
English: Cross-resistance between abacavir, lamivudine or zidovudine and antiretrovirals from other classes e.g. PIs or NNRTIs is unlikely.
Croatian: Križna rezistencija između abakavira, lamivudina ili zidovudina i antiretrovirusnih lijekova iz drugih skupina npr. PI ili NNRTI nije vjerojatna.
English: In vitro antagonism of anti-HIV activity between stavudine and zidovudine could result in decreased efficacy of both drugs.
Croatian: In vitro antagonizam anti-HIV aktivnosti može rezultirati sniženom djelotvornošću za oba lijeka.
English: Caution should be exercised when administering zidovudine to any patient (particularly obese women) with hepatomegaly, hepatitis or other known risk factors for liver disease and hepatic steatosis (including certain medicinal products and alcohol).
Croatian: Treba biti oprezan prilikom primjene zidovudina u svakog bolesnika (osobito u pretilih žena) s hepatomegalijom, hepatitisom ili drugim čimbenicima rizika za bolest jetre i hepatalnu steatozu (uključujući neke lijekove i alkohol).
English: There was no significant difference in the time to first virologic failure (p=0.73, log-rank test) between the 2 arms.
Croatian: Između dvije terapijske grane nije bilo značajne razlike u vremenu potrebnom za razvoj prvog virološkog neuspjeha (p=0,73, log-rank test).
English: Trizivir should not be taken with any other medicinal products containing lamivudine or medicinal products containing emtricitabine.
Croatian: Trizivir se ne smije uzimati s drugim lijekovima koji sadrže lamivudin ili emtricitabin.
English: You must carefully read all the information under ‘Hypersensitivity reactions' in the panel in Section 4.
Croatian: Morate pažljivo pročitati sve informacije u okviru 'Reakcije preosjetljivosti' u dijelu 4.
English: In rare cases, as the immune system becomes stronger, it can also attack healthy body tissue (autoimmune disorders).
Croatian: Kako postaje snažniji, imunološki sustav u rijetkim slučajevima može napadati i zdravo tkivo u tijelu (autoimuni poremećaji).
English: Rechallenge can result in a more rapid and severe reaction, which can be fatal, therefore rechallenge is contraindicated.
Croatian: Ponovno uvođenje ABCa može rezultirati puno bržom i težom reakcijom, što može biti fatalno, stoga je ponovno uvođenje kontraindicirano.
English: Data from clinical trials showed limited numbers of myocardial infarction and could not exclude a small increase in risk.
Croatian: Podaci kliničkih istraživanja su pokazali ograničen broj infarkta miokarda u tih pacijenata i mali porast rizika se nije mogao isključiti.
English: The likelihood of metabolic drug interactions with lamivudine is low due to the small extent of hepatic metabolism (5 - 10 %) and low plasma binding.
Croatian: Vjerojatnost metaboličkih interakcija lamivudina s drugim lijekovima je mala zbog niskog opsega metabolizma u jetri (5 - 10%) i slabog vezanja za plazmatske proteine.
English: IMPORTANT - ALERT CARD TRIZIVIR (abacavir sulfate / lamivudine / zidovudine) Tablets Carry this card with you at all times
Croatian: VAŽNO - KARTICA S UPOZORENJEM TRIZIVIR (abakavirsulfat / lamivudin / zidovudin) tablete Ovu karticu uvijek nosite sa sobom
English: In long-term oral carcinogenicity studies in rats and mice, lamivudine did not show any carcinogenic potential.
Croatian: U dugotrajnim ispitivanjima oralne karcinogenosti u štakora i miševa lamivudin nije pokazao nikakav karcinogeni potencijal.
English: • enlarged breasts in men
Croatian: • povećanje dojki u muškaraca.
English: Virologic success (48 weeks HIV RNA < 50 copies/ml)
Croatian: Uspješan virološki odgovor (48 tjedana HIV RNA < 50 kopija/ml)
English: • fever (high temperature) and skin rash
Croatian: • vrućica (visoka temperatura) i osip po koži.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in the rabbit at relatively low systemic exposures, comparable to those achieved in humans.
Croatian: Lamivudin nije pokazao teratogeni učinak u ispitivanjima na životinjama, ali bilo je znakova koji su upućivali na porast rane smrtnosti embrija u kunića pri relativno niskoj sistemskoj izloženosti u usporedbi s onom u ljudi.
English: The antiviral activity of abacavir in cell culture was not antagonized when combined with the nucleoside reverse transcriptase inhibitors (NRTIs) didanosine, emtricitabine, stavudine or tenofovir, the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, or the protease inhibitor (PI) amprenavir.
Croatian: Antivirusna aktivnost abakavira u kulturi stanica nije bila antagonizirana kad se primjenjivao u kombinaciji s nukleozidnim inhibitorima reverzne transkriptaze (NRTI) didanozinom, emtricitabinom, lamivudinom, stavudinom ili tenofovirom, s nenukleozidnim inhibitorom reverzne transkriptaze (NNRTI) nevirapinom ili inhibitorom proteaze (PI) amprenavirom.
English: Antivirals for systemic use, antivirals for treatment of HIV infections, combinations.
Croatian: Antivirotici za sistemsku primjenu, antivirotici za liječenje HIV-a, kombinacije.
English: If lamivudine is being used concomitantly for the treatment of HIV and HBV, additional information relating to the use of lamivudine in the treatment of hepatitis B infection is available in the Zeffix SmPC.
Croatian: Ako se lamivudin istodobno koristi za liječenje HIV i HBV infekcija, dodatne informacije o uporabi lamivudina u liječenju hepatitisa B dostupne su u sažetku opisa svojstava lijeka za Zeffix tablete.
English: Lamivudine-TP, carbovir-TP (the active triphosphate form of abacavir) and zidovudine-TP are substrates for and competitive inhibitors of HIV reverse transcriptase (RT).
Croatian: Lamivudin-TP, karbovir-TP (aktivni trifosfatni oblik abakavira) i zidovudin-TP su supstrati i kompetitivni inhibitori HIV reverzne transkriptaze (RT).
English: Data show that abacavir, lamivudine and zidovudine penetrate the central nervous system (CNS) and reach the cerebrospinal fluid (CSF).
Croatian: Podaci pokazuju da abakavir, lamivudin i zidovudin prodiru u središnji živčani sustav (SŽS) i ulaze u cerebrospinalnu tekućinu (CST).
English: If you get any symptoms of infection while you're taking Trizivir: Tell your doctor immediately.
Croatian: Ako razvijete bilo koji od simptoma infekcije prilikom uzimanja lijeka Trizivir: Odmah obavijestite svog liječnika.
English: Zidovudine has no effect on the pharmacokinetics of lamivudine.
Croatian: Zidovudin nema farmakokinetičkih učinaka na lamivudin.
English: In patients with mild hepatic impairment (Child-Pugh score 5-6) close monitoring is required, including monitoring of abacavir plasma levels if feasible (see sections 4.4 and 5.2).
Croatian: Bolesnika s blagim oštećenjem funkcije jetre (Child-Pugh skor 5-6 ) potrebno je pažljivo pratiti, uključujući praćenje razine abakavira u plazmi, ako je moguće (vidjeti dio 4.4 i 5.2).