FrancophonIA/ELRC3.0 huggingface dataset:
English: There are no data on the effects of levodopa or carbidopa on human fertility.
Slovenian: Ni podatkov o učinkih levodope ali karbidope na plodnost pri človeku.
English: If you have any of the following symptoms during your treatment with Numient, contact your doctor immediately:
Slovenian: Če se med jemanjem zdravila Numient pojavijo kateri koli izmed naštetih simptomov, takoj obvestite zdravnika:
English: What Numient is and what it is used for What you need to know before you take Numient How to take Numient
Slovenian: Kaj je zdravilo Numient in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Numient Kako jemati zdravilo Numient Možni neželeni učinki
English: Both levodopa and combinations of carbidopa and levodopa have caused visceral and skeletal malformations in rabbits.
Slovenian: Levodopa ter kombinacije karbidope in levodope so povzročale visceralne in skeletne deformacije pri kuncih.
English: Levodopa/carbidopa can cause orthostatic hypotension.
Slovenian: Levodope/karbidopa lahko povzroči ortostatsko hipotenzijo.
English: Patients must be informed of this and advised to exercise caution while driving or operating machines during treatment (see section 4.7).
Slovenian: Bolnike je treba o tem poučiti in jim svetovati, naj bodo med zdravljenjem pri vožnji ali upravljanju vozil in strojev previdni (glejte poglavje 4.7).
English: Numient is not recommended during pregnancy and in women of childbearing potential not using contraception, unless the benefits for the mother outweigh the possible risks to the foetus.
Slovenian: Zdravila Numient ne uporabljajte pri nosečnicah in ženskah v rodni dobi, ki ne uporabljajo učinkovite kontracepcije, razen če koristi za mater odtehtajo morebitna tveganja za plod.
English: Following a single dose of Numient in patients with Parkinson's disease the plasma AUC and Cmax of levodopa was higher in females than males (on average, 37% for AUC and 35% for Cmax).
Slovenian: Po enkratnem odmerku zdravila Numient pri bolnikih s Parkinsonovo boleznijo sta bili vrednosti AUC in Cmax levodope v plazmi večji pri ženskah kot pri moških (vrednost AUC je bila povprečno 37 % večja, Cmax pa 35 %).
English: It prevents metabolism of levodopa to dopamine in the peripheral circulation, ensuring that a higher proportion of the dose reaches the brain, where dopamine exerts its therapeutic effects.
Slovenian: Preprečuje presnovo levodope v dopamin v perifernem krvnem obtoku in tako zagotavlja dostop večjega deleža odmerka do možganov, kjer dopamin terapevtsko učinkuje.
English: It does not cross the blood-brain barrier and does not affect the metabolism of levodopa within the central nervous system.
Slovenian: Ne prehaja krvno-možganske pregrade in ne vpliva na presnovo levodope v osrednjem živčevju.
English: In particular, tell your doctor or pharmacist if you are taking the following medicines: Other medicines for Parkinson's disease, such as ‘anticholinergics' (e.g. orphenadrine and trihexyphenidyl), ‘selective MAO-B inhibitors' (e.g. selegiline and rasagiline), and a ‘COMT inhibitor' (e.g. entacapone)
Slovenian: Še zlasti morate obvestiti zdravnika ali farmacevta, če jemljete katero od naslednjih zdravil: druga zdravila proti Parkinsonovi bolezni, kot so »antiholinergiki« (npr. orfenadrin in triheksifenidil), »selektivne zaviralce MAO tipa B« (npr. selegilin in razagilin) in »zaviralec katehol-O-metiltransferaze « (npr. entakapon);
English: Carbidopa does not cross the blood-brain barrier at clinically relevant doses.
Slovenian: Karbidopa ne prehaja skozi krvno-možgansko pregrado v klinično pomembnih količinah.
English: Dose linearity
Slovenian: Linearnost odmerka
English: Certain side effects such as sleepiness and dizziness that have been reported with this modified-release levodopa/carbidopa capsule medicinal product may affect some patients' ability to drive or operate machinery.
Slovenian: Nekateri neželeni učinki o katerih so poročali pri teh kapsulah s prirejenim sproščanjem, ki vsebujejo levodopo/karbidopo, lahko vplivajo na sposobnost nekaterih bolnikov za vožnjo ali upravljanje strojev.
English: if you are allergic to levodopa or carbidopa, or any of the other ingredients of this medicine (listed in section 6); if you have narrow-angle glaucoma (an eye disorder); if you have phaeochromocytoma (a rare tumour of the adrenal gland); if you are taking certain medicines for treating depression [non-selective monoamine oxidase (MAO) inhibitors].
Slovenian: če ste alergični na levodopo, karbidopo ali katero koli sestavino tega zdravila (navedeno v poglavju 6); če imate glavkom z ozkim zakotjem (očesno bolezen); če imate feokromocitom (redki tumor nadledvične žleze); če jemljete določena zdravila za zdravljenje depresije [(neselektivne zaviralce monoaminoksidaze (zaviralce MAO)].
English: Effects of levodopa on fertility were evaluated in mouse studies (see section 5.3).
Slovenian: Vplive levodope na plodnost so ocenili v študijah pri miših (glejte poglavje 5.3).
English: However, levodopa has been shown to mildly affect mating behaviour in male rats.
Slovenian: Opazili pa so, da levodopa blago vpliva na paritveno vedenje pri podganah.
English: Co-administration with non-selective monoamine oxidase (MAO) inhibitors.
Slovenian: Sočasna uporaba z neselektivnimi zaviralci monoaminoksidaze (MAO).
English: In patients with Parkinson's disease, multiple-dose pharmacokinetics was comparable to single-dose pharmacokinetics, i.e. there was a minimal accumulation of levodopa from the modified-release levodopa/carbidopa medicinal product.
Slovenian: Pri bolnikih s Parkinsonovo boleznijo je bila farmakokinetika večkratnih odmerkov primerljiva s farmakokinetiko enkratnih odmerkov, tj. prišlo je do minimalnega kopičenja levodope iz zdravila s prirejenim sproščanjem, ki vsebuje levodopo/karbidopo.
English: If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Numient.
Slovenian: Če niste prepričani, ali kar koli od navedenega velja za vas, se posvetujte z zdravnikom ali farmacevtom, preden začnete jemati zdravilo Numient.
English: These can be symptoms of neuroleptic malignant syndrome (NMS, a rare severe reaction to medicines used to treat disorders of the central nervous system) or rhabdomyolisis (a rare severe muscle disorder)
Slovenian: To so lahko simptomi nevroleptičnega malignega sindroma (NMS, redke hude reakcije na zdravila, ki se uporabljajo za zdravljenje bolezni osrednjega živčevja) ali rabdomiolize (redke hude mišične bolezni).
English: Levodopa/carbidopa preparations may provide a false-positive test result for ketone bodies, if a test strip is used for determining any ketonuria.
Slovenian: Zdravila z levodope/karbidopo lahko povzročijo lažno pozitivne rezultate pri testiranju ketonskih teles s testnimi lističi za določanje ketonurije.
English: EXP After opening the bottle, use within 90 days.
Slovenian: EXP Po odprtju vsebnika uporabite zdravilo v 90 dneh.
English: Change from baseline at week 30 (or at early termination)c)
Slovenian: Sprememba glede na izhodišče po 30 tednih (ali ob predčasni prekinitvi zdravljenja)c)
English: The safety and efficacy of Numient in children under 18 years of age have not been established.
Slovenian: Varnost in učinkovitost zdravila Numient pri otrocih, mlajših od 18 let, nista bili dokazani.
English: Patients with advanced Parkinson's disease
Slovenian: Bolniki z napredovalo Parkinsonovo boleznijo
English: If you stop taking Numient
Slovenian: Če ste prenehali jemati zdravilo Numient
English: Features of randomized patients
Slovenian: N randomiziranih bolnikov
English: Doses of a few grams may result in CNS disturbances, with an increasing likelihood of cardiovascular disturbance (e.g. hypotension, sinus tachycardia) and more severe psychiatric problems at higher doses.
Slovenian: Nekajgramski odmerki lahko povzročijo motnje osrednjega živčevja s povečano verjetnostjo za motnje srčno-žilnega sistema (npr. hipotenzije, sinusne tahikardije), pri večjih odmerkih pa se lahko pojavijo resnejše psihiatrične težave.
English: The ADVANCE-PD study was a 22-week study consisting of a 3-week dose adjustment of pre-study immediate release levodopa/carbidopa treatment prior to a 6-week conversion to Numient.
Slovenian: Študija ADVANCE-PD je bila 22-tedenska študija, ki je vključevala 3-tedensko prilagajanje odmerka predštudijskega zdravljenja z zdravilom s takojšnjim sproščanjem, ki vsebuje levodopo/karbidopo, pred 6-tedenskim obdobjem prehoda na zdravilo Numient.
English: Non-selective monoamine oxidase inhibitors must be discontinued at least 2 weeks prior to treatment initiation with the modified-release levodopa/carbidopa capsule medicinal product (see section 4.3).
Slovenian: Uporabo neselektivnih zaviralcev monoaminoksidaze je treba prekiniti vsaj 2 tedna pred začetkom zdravljenja s kapsulami s prirejenim sproščanjem, ki vsebujejo levodopo/karbidopo (glejte poglavje 4.3).
English: Effect of levodopa and carbidopa on the metabolism of other medicinal products
Slovenian: Vpliv levodope in karbidope na presnovo drugih zdravil
English: Patients with chronic wide-angle glaucoma may be treated cautiously with levodopa/carbidopa provided the intraocular pressure is well-controlled and the patient is monitored carefully for changes in intraocular pressure during therapy.
Slovenian: Pri bolnikih z glavkomom s širokim zakotjem se sme uporabiti levodopa/karbidopa, vendar previdno ter le, če je intraokularni tlak dobro nadzorovan in se pri bolniku pozorno spremlja spremembe intraokularnega tlaka med zdravljenjem.
English: It helps levodopa work more effectively by slowing the speed at which levodopa is broken down in your body.
Slovenian: Pomaga pri učinkovitejšem delovanju levodope, tako da upočasni njeno razgradnjo v telesu.
English: One bottle containing 25, 100 or 240 modified-release hard capsules.
Slovenian: En vsebnik vsebuje 25, 100 ali 240 trdih kapsul s prirejenim sproščanjem.
English: If you need to have tests on your blood or urine, tell the doctor or nurse that you are taking Numient.
Slovenian: Če vam bodo odvzeli vzorec krvi ali urina, povejte zdravniku ali medicinski sestri, da jemljete zdravilo Numient.
English: NMS is a life-threatening syndrome characterized by fever or hyperthermia and can be associated with rhabdomyolysis.
Slovenian: NMS je smrtno nevaren sindrom, za katerega je značilna povišana telesna temperatura ali hipertermija, lahko pa je povezan tudi z rabdomiolizo.
English: If you take more Numient than you should (or someone has accidentally ingested Numient) talk to your doctor or pharmacist immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Numient, kot bi smeli Če ste vzeli večji odmerek zdravila Numient, kot bi smeli (ali je kdo nehote zaužil zdravilo Numient), takoj obvestite zdravnika ali farmacevta.
English: As a result of Numient's pharmacokinetic characteristics, the doses and dosing frequency of Numient are not directly interchangeable with those of other levodopa/DDC inhibitor immediate release medicinal products (see section 5.2).
Slovenian: Zaradi farmakokinetičnih značilnosti zdravila Numient odmerki in pogostnost odmerjanja zdravila Numient niso neposredno enakovredni odmerkom in pogostnostim odmerjanja drugih zdravil s takojšnjim sproščanjem, ki vsebujejo levodopo/zaviralec DDC (glejte poglavje 5.2).
English: “Off” time (hrs)*
Slovenian: Čas »izklopa« (h)*
English: Carbidopa inhibits decarboxylation of peripheral levodopa.
Slovenian: Karbidopa zavira dekarboksilacijo periferne levodope.
English: There is insufficient information on the effects of levodopa/carbidopa or their metabolites in newborns/infants.
Slovenian: Informacije o učinkih levodope/karbidope ali njunih presnovkih pri novorojenčkih/dojenčkih so nezadostne.
English: Impact of renal function on levodopa/carbidopa clearance is limited (see section 5.2).
Slovenian: Vpliv delovanja ledvic na očistek levodope/karbidope je omejen (glejte poglavje 5.2).
English: Bleeding in your stomach or intestines which may be seen as blood in your faeces or darkened faeces An allergic reaction, the signs of which may include hives (nettle rash), itching, rash, swelling of your face, lips, tongue or throat.
Slovenian: krvavitve v želodcu ali črevesju, ki jih lahko vidite kot kri v blatu ali temnejše blato; alergijska reakcija, katere znaki lahko vključujejo koprivnico, srbenje, izpuščaj in otekanje obraza, ustnic, jezika ali grla.
English: Caution should be exercised when interpreting the plasma and urine levels of catecholamines and their metabolites in patients on levodopa or levodopa/carbidopa therapy.
Slovenian: Pri tolmačenju ravni kateholaminov in njihovih presnovkov v plazmi ter urinu pri bolnikih, ki prejemajo levodopo ali levodopo/karbidopo, je potrebna previdnost.
English: The ASCEND-PD study was a randomized, double-blind, 2-treatment, 2-period crossover study in which 110 patients on a stable regimen of levodopa/carbidopa/entacapone (LCE) containing at least 400 mg per day of levodopa were included.
Slovenian: Študija ASCEND-PD je bila randomizirana, dvojno slepa, navzkrižna študija 2 odmerkov in 2 obdobij, v katero je bilo vključenih 110 bolnikov na stabilnem režimu zdravljenja s kombinacijo levodope/karbidope/entakapona (LCE), ki je vseboval vsaj 400 mg levodope na dan. Najmanjša pogostnost odmerjanja po vstopu v preskušanje je bila 4-krat na dan vsaj 4 tedne.
English: Dopamine D2 receptor antagonists, benzodiazepines and isoniazid
Slovenian: Antagonisti dopaminskih receptorjev D2, benzodiazepini in izoniazid
English: Levodopa competes with certain amino acids for transport, therefore high protein meals may impair the absorption of levodopa.
Slovenian: Med levodope in nekaterimi aminokislinami obstaja kompeticija pri transportu, zato obroki z veliko vsebnostjo beljakovin lahko zmanjšajo absorpcijo levodope.
English: Carbidopa
Slovenian: Karbidopa
English: Patients should be maintained on the lowest dose required to achieve symptomatic control and to minimize adverse reactions such as dyskinesia and nausea.
Slovenian: Bolnikom je treba dajati najmanjši odmerek, potreben za doseganje nadzora simptomov, da se zmanjšajo neželeni učinki, kot sta diskinezija in navzea.
English: Levodopa
Slovenian: Levodope
English: There is a recognized drug-drug interaction of levodopa with type B MAO inhibitors which potentiates the effects of levodopa.
Slovenian: Znane so interakcije med levodopo in zaviralci MAO tipa B, ki okrepijo učinke levodope.
English: Levodopa/carbidopa and ferrous salts or multivitamins containing ferrous salts should be co-administered with caution.
Slovenian: Pri sočasni uporabi levodope/karbidope in železovih soli ali multivitaminov, ki vsebujejo železove soli, je potrebna previdnost.
English: Mean UPDRS (Part II and Part III) Score a)
Slovenian: Povprečen rezultat UPDRS (2. in 3. del)
English: Ferrous salts
Slovenian: Železove soli
English: Inhibition or induction effects of levodopa and carbidopa have not been investigated.
Slovenian: Učinkov zaviranja ali indukcije pri levodopi in karbidopi niso raziskovali.
English: Levodopa is a precursor of dopamine, and is given as dopamine replacement therapy in Parkinson's disease.
Slovenian: Levodope je prekurzor dopamina, uporablja pa se pri nadomestni dopaminski terapiji pri Parkinsonovi bolezni.
English: Do not break, crush or chew the capsules
Slovenian: Kapsul ne smete zlomiti, zdrobiti ali jih žvečiti.
English: Neurological findings, including muscle rigidity, involuntary movements, altered consciousness, mental status changes; other disturbances, such as autonomic dysfunction, tachycardia, tachypnoea, sweating, hyper- or hypotension; laboratory findings, such as creatine phosphokinase elevation, leucocytosis, myoglobinuria, and increased serum myoglobin have been reported.
Slovenian: Poročali so o nevroloških ugotovitvah, vključno s togostjo mišic, nehotenimi gibi, motnjami zavesti, spremembami duševnega stanja; drugih motnjah, kot so disavtonomija, tahikardija, tahipneja, znojenje, hiper- ali hipotenzija; laboratorijskih ugotovitvah, kot so povišana kretinfosfokinaza, levkocitoza, mioglobinurija in povišan mioglobin v serumu.
English: The modified-release hard capsule should be swallowed whole, and not chewed or crushed, in order to maintain the modified-release effect of the levodopa/carbidopa medicinal product.
Slovenian: Trdo kapsulo s prirejenim sproščanjem morajo bolniki pogoltniti celo in je ne smejo žvečiti ali zdrobiti, da se ohrani učinek prirejenega sproščanja zdravila, ki vsebuje levodopo/karbidopo.
English: Numient can be taken concomitantly with the recommended dose of an MAO inhibitor, which is selective for MAO inhibitor type B such as selegiline and rasagiline.
Slovenian: Zdravilo Numient se lahko jemlje sočasno s priporočenim odmerkom zaviralca MAO tipa B, kot sta selegilin in razagilin.
English: Levodopa has been associated with somnolence and episodes of sudden sleep onset (see section 4.7).
Slovenian: Somnolenca in epizode nenadnega nastopa spanca Levodope je povezana s somnolenco in epizodami nenadnega nastopa spanca (glejte poglavje 4.7).
English: Next, patients were randomized to a double-blind, 13-week study treatment period of either optimized immediate release levodopa/carbidopa treatment or Numient.
Slovenian: Bolniki so bili nato randomizirani v dvojno slepo, 13-tedensko obdobje zdravljenja v študiji, kjer so prejemali optimizirano zdravljenje z zdravilom s takojšnjim sproščanjem, ki vsebuje levodopo/karbidopo ali zdravilo Numient.
English: Patients being treated with this modified-release levodopa/carbidopa capsule medicinal product and presenting with somnolence and/or sudden sleep episodes must be informed to refrain from driving or engaging in activities where impaired alertness may put themselves or others at risk of serious injury or death (e.g. operating machines), until such recurrent episodes and somnolence have resolved (see also section 4.4).
Slovenian: Bolnike, pri katerih se med zdravljenjem s temi kapsulami s prirejenim sproščanjem, ki vsebujejo levodopo/karbidopo, pojavijo somnolenca in/ali epizode nenadnega nastopa spanca, je treba opozoriti, da ne smejo voziti ali opravljati dejavnosti (npr. upravljanje strojev), pri katerih bi zaradi njihove zmanjšane zbranosti lahko prišlo do resnih poškodb ali smrti pri njih samih ali drugih ljudeh, dokler ponavljajoče se epizode nastopa spanca in somnolenca ne minejo (glejte tudi poglavje 4.4).
English: levodopa turns into a material called ‘dopamine' in your brain.
Slovenian: Levodopa se v možganih spremeni v snov, imenovano »dopamin«.
English: In vivo, co-administration of Numient with up to 40% volume-to-volume (v/v) alcohol did not result in dosedumping of levodopa or carbidopa.
Slovenian: Sočasna uporaba zdravila Numient in alkohola pri volumski koncentraciji do 40 % (v/v) in vivo ni povzročila sprostitve celotnega odmerka levodope ali karbidope.
English: Initial total daily dose of Numient (levodopa in mg)
Slovenian: Začetni skupni dnevni odmerek zdravila Numient (levodope v mg)
English: b) Combined term that includes atrial fibrillation, atrial flutter, atrioventricular block, bundle branch block, sick sinus syndrome, bradycardia, and tachycardia
Slovenian: b) Kombiniran izraz, ki vključuje atrijsko fibrilacijo, atrijsko undulacijo, atrioventrikularni blok, kračni blok, sindrom bolnega sinusnega vozla, bradikardijo in tahikardijo.
English: It is recommended to monitor patients for the onset or evolution of dyskinesia and to adjust levodopa/carbidopa doses accordingly.
Slovenian: Pri bolnikih je priporočljivo spremljati morebiten nastop ali razvoj diskinezije in ustrezno prilagoditi odmerke levodope/karbidope.
English: Levodopa crosses the blood-brain barrier by active transporters for large neutral amino acids.
Slovenian: Levodope prehaja krvnomožgansko pregrado prek transportnih beljakovin za velike nevtralne aminokisline.
English: The dopamine helps to improve the symptoms of your Parkinson's disease.
Slovenian: Dopamin pomaga izboljšati simptome Parkinsonove bolezni.
English: There are no studies on the pharmacokinetics of levodopa and carbidopa in patients with hepatic impairment (see section 4.2).
Slovenian: Študij farmakokinetike levodope in karbidope pri bolnikih z jetrno okvaro ni (glejte poglavje 4.2).
English: The use of Numient is not recommended in patients under 18 years of age.
Slovenian: Uporaba zdravila Numient pri bolnikih, mlajših od 18 let, ni priporočljiva.
English: Since its decarboxylase inhibiting activity is limited to extracerebral tissues, administration of carbidopa with levodopa makes more levodopa available for delivery to the brain.
Slovenian: Njena aktivnost zaviranja dekarboksilaze je omejena na zunajmožganska tkiva, zato je pri sočasni uporabi karbidope in levodope več levodope razpoložljive za dovajanje v možganih.
English: If this applies to you, do not take Numient and ask your doctor or pharmacist for advice.
Slovenian: Če to velja za vas, ne jemljite zdravila Numient in se posvetujte z zdravnikom ali farmacevtom.
English: The medicinal product/food mixture should be swallowed completely and immediately without chewing and should not be stored for future use.
Slovenian: Celotno zmes zdravila in hrane je treba pogoltniti takoj in brez žvečenja.
English: Alternatively, for patients that have difficulty swallowing a capsule, this medicinal product may be administered by carefully opening the capsule and sprinkling the entire contents on a small amount (e.g., 2 tablespoons) of soft food such as apple sauce, yoghurt, or pudding.
Slovenian: Pri bolnikih, ki ne morejo pogoltniti cele kapsule, se lahko to zdravilo daje tudi tako, da se kapsula previdno odpre in se celotna vsebina iztrese na majhno količino (npr. dve žlici) mehke hrane, na primer jabolčne kaše, jogurta ali pudinga.
English: Talk to your doctor or pharmacist before taking Numient if you have, have ever had, or develop: sudden sleep attacks or sometimes feel very sleepy any form of severe mental disorder like psychosis feelings of depression, suicidal thoughts, or notice unusual changes in your behaviour tremors, agitation, confusion, fever, rapid pulse, or wide fluctuations in your blood pressure, or notice that your muscles get very rigid or jerk violently.
Slovenian: Pred začetkom jemanja zdravila Numient se posvetujte z zdravnikom ali farmacevtom, če imate, ste kdaj imeli ali se pojavijo: napadi nenadnega spanca ali če ste včasih zelo zaspani; kakršna koli oblika duševne motnje, kot je psihoza; občutki depresije, samomorilne misli, ali če opazite nenavadne spremembe v svojem vedenju; tresenje, agitacija, zmedenost, povišana telesna temperatura, hiter srčni utrip ali močna nihanja krvnega tlaka, ali če opazite, da vaše mišice postanejo zelo toge ali da močno trzajo.
English: When converting patients from levodopa/DDC inhibitor medicinal products to Numient, the dose should be adjusted to maintain sufficient symptomatic control.
Slovenian: Pri prehodu bolnikov z zdravil, ki vsebujejo levodopo/zaviralec DDC, na zdravilo Numient je treba odmerek prilagoditi tako, da se vzdržuje ustrezni nadzor simptomov.
English: The primary efficacy endpoint was the mean change from baseline of the Unified Parkinson's Disease Rating Scale (UPDRS) Part II (activities of daily living) score plus Part III motor score at week 30 or early termination.
Slovenian: Primarni opazovani dogodek učinkovitosti je bila povprečna sprememba rezultata 2. dela enotne ocenjevalne lestvice za Parkinsonovo bolezen (UPDRS- Unified Parkinson's Disease Rating Scale) (vsakodnevne dejavnosti) in 3. dela (ocena motorične funkcije) glede na izhodišče po 30 tednih ali do predčasne prekinitve zdravljenja.
English: Following multiple dosing in patients, modified-release levodopa/carbidopa had reduced fluctuations in levodopa plasma concentrations with peak-to-trough fluctuation index of 1.5 with minimal accumulation of levodopa.
Slovenian: Po večkratnem odmerjanju pri bolnikih je zdravilo s prirejenim sproščanjem, ki vsebuje levodopo/karbidopo, zmanjšalo nihanja koncentracij levodope v plazmi z indeksom odstopanja koncentracije pred naslednjim odmerkom 1,5 in z minimalnim kopičenjem levodope.