FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients already intubated and sedated may switch to dexmedetomidine with an initial infusion rate of 0.7 micrograms/kg/h which may then be adjusted stepwise within the dose range 0.2 to 1.4 micrograms/kg/h in order to achieve the desired level of sedation, depending on the patient's response.
Slovenian: Pri bolnikih, ki so že intubirani in sedirani, lahko preidete na uporabo deksmedetomidina z začetno hitrostjo infundiranja 0,7 mikrogramov/kg/h, ki jo lahko potem po korakih povečujete v razponu odmerkov od 0,2 do 1,4 mikrograma/kg/h, da boste dosegli želeno stopnjo sedacije glede na bolnikov odziv.
English: However, due to possible pharmacodynamic interactions, when co-administered with dexmedetomidine, a reduction in dosage of dexmedetomidine or the concomitant anaesthetic, sedative, hypnotic or opioid may be required.
Slovenian: Zaradi možnosti farmakodinamičnih interakcij je pri sočasni uporabi z deksmedetomidinom lahko potrebno zmanjšanje odmerka deksmedetomidina ali drugega sočasno uporabljenega anestetika, sedativa, hipnotika ali opioida.
English: What Dexdor looks like and contents of the pack
Slovenian: Izgled zdravila Dexdor in vsebina pakiranja
English: How to use Dexdor
Slovenian: Kako uporabljati zdravilo Dexdor
English: 1 See section on Description of selected adverse reactions 2 Adverse reaction observed also in procedural sedation studies 3 Incidence ‘common' in ICU sedation studies
Slovenian: 2 Neželeni učinek, opažen tudi v študijah proceduralne sedacije 3 Incidenca "pogosti" v študijah sedacije na oddelkih za intenzivno nego
English: The pharmacokinetics of dexmedetomidine has been assessed following short term IV administration in healthy volunteers and long term infusion in ICU population.
Slovenian: Farmakokinetiko deksmedetomidina so ovrednotili po kratkotrajni intravenski uporabi pri zdravih prostovoljcih in po dolgotrajnem infundiranju pri populaciji bolnikov z oddelkov za intenzivno nego.
English: 400 mcg/ 4 ml
Slovenian: 400 µg/4 ml
English: Uncommon: Atrioventricular block first degree, cardiac output decreased
Slovenian: atrioventrikularni blok prve stopnje, zmanjšan minutni srčni volumen
English: - The maintenance infusion is generally initiated at 0.6-0.7 microgram/kg/hour and titrated to achieve desired clinical effect with doses ranging from 0.2 to 1 microgram/kg/hour.
Slovenian: - vzdrževalna infuzija se običajno začne s hitrostjo 0,6-0,7 mikrograma/kg/uro, sledi titriracija z odmerki od 0,2 do 1 mikrograma/kg/uro do dosega želenega kliničnega učinka.
English: Dexdor contains less than 1 mmol sodium (23 mg) per ml.
Slovenian: Zdravilo Dexdor vsebuje manj kot 1 mmol natrija (23 mg) na ml.
English: Dexdor is intended for use in an intensive care setting, operating room and during diagnostic procedures.
Slovenian: Zdravilo Dexdor je namenjeno uporabi na oddelkih za intenzivno nego, v operacijskih sobah in med diagnostičnimi postopki.
English: Clinically significant hypotension or bradycardia should be treated as described in section 4.4.
Slovenian: Opis izbranih neželenih učinkov Klinično pomembno hipotenzijo ali bradikardijo je treba zdraviti, kakor je opisano v poglavju 4.4.
English: Metabolite H-1, N-methyl 3-hydroxymethyl dexmedetomidine O-glucuronide, is also a major circulating product of dexmedetomidine biotransformation.
Slovenian: Tudi presnovek H-1, N-metil 3-hidroksimetil deksmedetomidin Oglukuronid, je poglaviten produkt biotransformacije deksmedetomidina v krvi.
English: Patients failing to achieve an adequate level of sedation with the maximum dose of dexmedetomidine should be switched to an alternative sedative agent.
Slovenian: Pri bolnikih, pri katerih ne morete doseči zadostne stopnje sedacije z največjim odmerkom deksmedetomidina, morate uporabiti drugo učinkovino s sedativnim delovanjem.
English: The concentration of the final solution after dilution should be either 4 micrograms/ml or 8 micrograms/ml.
Slovenian: Koncentracija končne raztopine po redčenju mora biti bodisi 4 mikrograme/ml ali 8 mikrogramov/ml.
English: It must be administered only as a diluted intravenous infusion using a controlled infusion device
Slovenian: Uporabljati ga je treba le v obliki razredčene intravenske infuzije s pripomočkom za nadzorovano infundiranje.
English: Patients should be advised to refrain from driving or other hazardous tasks for a suitable period of time after receiving Dexdor for procedural sedation.
Slovenian: 4.7 Vpliv na sposobnost vožnje in upravljanja strojev Bolnikom je treba svetovati, naj za ustrezno časovno obdobje po prejemu zdravila Dexdor za proceduralno sedacijo ne vozijo ali izvajajo drugih nevarnih aktivnosti.
English: - A loading infusion of 1.0 microgram/kg over 10 minutes.
Slovenian: Uvedba sedacije pri ohranjeni zavesti: - udarna infuzija 1,0 mikrograma/kg v 10 minutah.
English: For sedation of non-intubated adult patients prior to and/or during diagnostic or surgical procedures requiring sedation, i.e. procedural/awake sedation.
Slovenian: Za sedacijo neintubiranih odraslih bolnikov pred in/ali med diagnostičnimi ali kirurškimi posegi, ki zahtevajo sedacijo, t.i. proceduralno sedacijo/sedacijo pri ohranjeni zavesti.
English: Propofol or midazolam may be administered if needed until clinical effects of dexmedetomidine are established.
Slovenian: Po potrebi lahko bolniku dajete tudi propofol ali midazolam, dokler ne boste ugotovili kliničnih učinkov deksmedetomidina.
English: Taking into account the PRAC Assessment Report on the PSUR(s) for dexmedetomidine, the scientific conclusions of CHMP are as follows:
Slovenian: Upoštevajoč poročilo Odbora za oceno tveganja na področju farmakovigilance (PRAC) o oceni rednih posodobljenih poročil o varnosti zdravila (PSUR) za deksmedetomidin je Odbor za zdravila za uporabo v humani medicini (CHMP) sprejel naslednje znanstvene zaključke:
English: Caution is advised when administering dexmedetomidine together with spinal or epidural anaesthesia due to possible increased risk of hypotension or bradycardia.
Slovenian: Pri uporabi deksmedetomidina skupaj s spinalno ali epiduralno anestezijo je potrebna previdnost zaradi možnega povečanega tveganja za pojav hipotenzije ali bradikardije.
English: Evidence of paediatric efficacy was seen in a dose-controlled ICU study in a largely post-operative population aged 1 month to ≤ 17 years.
Slovenian: opravljeni na oddelku za intenzivno nego, na večinoma postoperativni populaciji v starosti od 1 meseca do ≤ 17 let.
English: Induction of dexmedetomidine in vitro was observed on CYP1A2, CYP2B6, CYP2C8, CYP2C9 and CYP3A4, and induction in vivo cannot be excluded.
Slovenian: Opazili so indukcijo deksmedetomidina in vitro na CYP1A2, CYP2B6, CYP2C8, CYP2C9 in
English: - If you get any side effects, talk to your doctor.
Slovenian: - Če opazite kateri koli neželeni učinek, se posvetujete z zdravnikom.
English: In the rat, subcutaneous administration at the maximum dose, 200 µg/kg/day, caused an increase in embryofetal death and reduced the fetal body weight.
Slovenian: Pri podganah je subkutano dajanje največjega odmerka 200 µg/kg/dan povzročilo povečano pogostnost smrti zarodkov in plodov in zmanjšalo telesno maso plodov.
English: A single case of hypothermic bradycardia in a neonate has been reported in the literature.
Slovenian: V literaturi so poročali o enem samem primeru hipotermične bradikardije pri novorojenčku.
English: Manufacturer Orion Corporation Orion Pharma Orionintie 1
Slovenian: Izdelovalec Orion Corporation Orion Pharma Orionintie 1
English: 2 ml glass ampoules 2, 5 or 10 ml glass vials
Slovenian: 2 ml steklene ampule 2, 5 ali 10 ml steklene viale
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, single and repeated dose toxicity and genotoxicity.
Slovenian: Predklinični podatki na osnovi običajnih študij farmakološke varnosti, toksičnosti pri enkratnih in ponavljajočih se odmerkih in genotoksičnosti ne kažejo posebnega tveganja za človeka.
English: 2 ml Type I glass ampoules
Slovenian: 2 ml ampule iz stekla tipa I
English: Not known (frequency cannot be estimated from the available data) - increased need to pass urine
Slovenian: - premajhna učinkovitost zdravila Neznana (ni mogoče oceniti iz razpoložljivih podatkov)
English: - The active substance is dexmedetomidine.
Slovenian: - Učinkovina je deksmedetomidin.
English: Advanced heart block (grade 2 or 3) unless paced.
Slovenian: Napredovali srčni blok (2. ali 3. stopnje), če bolnik nima srčnega spodbujevalnika.
English: Dexmedetomidine is very potent and the infusion rate is given per hour.
Slovenian: Deksmedetomidin je zelo močno zdravilo, zato je njegova hitrost infundiranja podana na uro.
English: Use of a loading dose of Dexdor in ICU sedation is not recommended and is associated with increased adverse reactions.
Slovenian: Uporaba udarnega odmerka zdravila Dexdor za sedacijo na oddelkih za intenzivno nego ni priporočljiva in je povezana s povečanjem neželenih učinkov.
English: Body weightadjusted plasma clearance in new-born infants (under 1 month) appeared lower (0.9 l/h/kg) than in the older groups due to immaturity.
Slovenian: zaradi nezrelosti nižji (0,9 l/h/kg) kot pri starejših skupinah.
English: The mean t1/2 for the subjects with mild, moderate or severe hepatic impairment was prolonged to 3.9, 5.4, and 7.4 hours, respectively.
Slovenian: Srednja vrednost t1/2 pri preiskovancih z blago jetrno okvaro je bila podaljšana na 3,9, pri tistih z zmerno jetrno okvaro na 5,4 in pri tistih s hudo jetrno okvaro na 7,4 ure.
English: Dexmedetomidine is metabolised in the liver and should be used with caution in patients with hepatic impairment.
Slovenian: Deksmedetomidin se presnovi v jetrih, zato ga je treba pri bolnikih z jetrno okvaro uporabljati previdno.
English: Also contains sodium chloride,water for injections.
Slovenian: SEZNAM POMOŽNIH SNOVI Vsebuje tudi natrijev klorid, vodo za injekcije.
English: Dexdor is given as a loading infusion followed by maintenance infusion.
Slovenian: Zdravilo Dexdor se daje kot udarna infuzija, ki ji sledi vzdrževalna infuzija.
English: In the reproductive toxicity studies, dexmedetomidine had no effect on male or female fertility in the rat, and no teratogenic effects were observed in the rat or rabbit.
Slovenian: V študijah vpliva na sposobnost razmnoževanja deksmedetomidin ni vplival na plodnost podganjih samic in samcev, pri podganah in kuncih pa tudi niso opažali nobenih teratogenih učinkov.
English: Dexdor contains an active substance called dexmedetomidine which belongs to a medicine group called sedatives.
Slovenian: Zdravilo Dexdor vsebuje učinkovino deksmedetomidin iz skupine zdravil, ki jim pravimo sedativi.
English: - if you have an abnormally slow heart rate (either due to illness or high levels of physical fitness) - if you have low blood pressure - if you have low blood volume, for example after bleeding - if you have certain heart disorders - if you are elderly - if you have a neurological disorder (for instance head or spinal cord injury or stroke) - if you have severe liver problems - if you have ever developed a serious fever after some medicines, especially anaesthetics
Slovenian: - če imate katero od srčnih bolezni, - če sodite med starostnike, - če imate nevrološko bolezen (na primer poškodbo glave ali hrbtenjače oziroma možgansko kap), - če imate hude težave z jetri, - če ste imeli kdaj v preteklosti močno zvišano temperaturo po prejemu nekaterih zdravil, še posebej anestetikov.
English: 5 x 2 ml ampoules 25 x 2 ml ampoules 5 x 2 ml vials 4 x 4 ml vials 4 x 10 ml vials
Slovenian: 5 x 2 ml ampule 25 x 2 ml ampule 5 x 2 ml viale 4 x 4 ml viale 4 x 10 ml viale
English: Hospital intensive care Dexdor is administered to you by a doctor or nurse in hospital intensive care.
Slovenian: Zdravilo Dexdor vam bo dal zdravnik ali medicinska sestra na bolnišničnem oddelku za intenzivno nego.
English: Marketing Authorisation Holder Orion Corporation Orionintie 1
Slovenian: Imetnik dovoljenja za promet Orion Corporation Orionintie 1
English: Pack sizes 5 x 2 ml ampoules 25 x 2 ml ampoules 5 x 2 ml vials 4 x 4 ml vials 4 x 10 ml vials
Slovenian: Velikosti pakiranj 5 x 2 ml ampule 25 x 2 ml ampule 5 x 2 ml viale 4 x 4 ml viale 4 x 10 ml viale
English: Those patients who withdrew due to insufficient sedation were switched to either propofol or midazolam.
Slovenian: Bolnikom, ki so bili nezadostno sedirani, so odvzeli deksmedetomidin in jim dali propofol ali midazolam.
English: Data in new-born infants (28 - 44 weeks gestation) to children 17 years of age are limited.
Slovenian: - 44. teden gestacije) in otroke stare do 17 let, je malo.
English: The mean plasma clearance values of unbound dexmedetomidine for subjects with mild, moderate, and severe hepatic impairment were 59%, 51% and 32% of those observed in the normal healthy subjects, respectively.
Slovenian: Srednje vrednosti plazemskega očistka nevezanega deksmedetomidina pri preiskovancih z blago jetrno okvaro znašajo 59 %, pri tistih z zmerno jetrno okvaro 51 % in pri tistih s hudo jetrno okvaro 32 % vrednosti, ugotovljenih pri normalnih zdravih preiskovancih.
English: There is no experience in the use of Dexdor for more than 14 days.
Slovenian: Ni izkušenj z uporabo zdravila Dexdor, daljšo od 14 dni, zato morate vsako daljšo uporabo zdravila Dexdor vedno ponovno oceniti.
English: Users should therefore be ready to use an alternative sedative for acute control of agitation or during procedures, especially during the first few hours of treatment.
Slovenian: Uporabniki morajo biti zato pripravljeni, da bodo morali bolniku dati kakšen drug sedativ za akuten nadzor agitacije oziroma med posegi.
English: MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJE
English: In placebo controlled trials in a post-operative ICU population previously intubated and sedated with midazolam or propofol, Dexdor significantly reduced the requirement for both rescue sedative
Slovenian: V s placebom nadzorovanih preskušanjih pri populaciji postoperativnih bolnikov na oddelkih za intenzivno nego, ki so bili predhodno intubirani in sedirani z midazolamom ali propofolom, je med sedacijo v času do 24 ur zdravilo Dexdor bistveno zmanjšalo potrebo tako po rešilnem sedativu (midazolamu ali propofolu) kot po opioidih.
English: Hypotension and bradycardia were also the most frequent dexmedetomidine-related serious adverse reactions occurring in 1.7% and 0.9% of randomised Intensive Care Unit (ICU) patients respectively.
Slovenian: Najpogostejša resna neželena učinka, povezana z uporabo deksmedetomidina, sta bila tudi hipotenzija, ki se je pojavljala pri 1,7 % in bradikardija, ki se je pojavljala pri 0,9 % randomiziranih bolnikov na oddelkih za intenzivno nego.
English: In isolated cases bradycardia has progressed to periods of asystole in patients with pre-existing bradycardia.
Slovenian: V redkih primerih je pri bolnikih z obstoječo bradikardijo le-ta napredovala do daljše asistolije.
English: The concentrate is a clear, colourless solution, pH 4.5 - 7.0
Slovenian: FARMACEVTSKA OBLIKA koncentrat za raztopino za infundiranje (sterilen koncentrat) Koncentrat je bistra in brezbarvna raztopina s pH vrednostjo med 4,5 in 7,0.
English: Dexdor is administered to you by a doctor or a nurse prior to and/or during diagnostic or surgical procedures requiring sedation, i.e. procedural/awake sedation.
Slovenian: Proceduralna sedacija/sedacija pri ohranjeni zavesti Zdravilo Dexdor vam bo dal zdravnik ali medicinska sestra pred in/ali med diagnostičnimi ali kirurškimi posegi, ki zahtevajo sedacijo, t.i. proceduralno sedacijo/sedacijo pri ohranjeni zavesti.
English: SPECIAL STORAGE CONDITIONS Keep the ampoules/vials in the outer carton in order to protect from light.
Slovenian: Ampule/viale shranjujte v zunanji ovojnini za zagotovitev zaščite pred svetlobo.
English: - if you are allergic to dexmedetomidine or any of the other ingredients of this medicine (listed in section 6).
Slovenian: Kaj morate vedeti, preden boste prejeli zdravilo Dexdor Zdravila Dexdor ne smete prejeti - če ste alergični na deksmedetomidin ali katero koli sestavino tega zdravila (navedeno v poglavju 6),
English: Dexmedetomidine is eliminated by extensive metabolism in the liver.
Slovenian: Deksmedetomidin se izloča z obsežno presnovo v jetrih.
English: Dexmedetomidine is relatively free from respiratory depressive effects when given as monotherapy to healthy subjects.
Slovenian: Deksmedetomidin takorekoč ne povzroča depresije dihanja, če se uporablja kot monoterapija pri zdravih ljudeh.
English: Delirium measured by the CAM-ICU scale was reduced in a study compared to midazolam and delirium-related adverse events were lower on dexmedetomidine compared to propofol.
Slovenian: V študiji primerjave z midazolamom je bil delirij, ki so ga merili z lestvico CAM-ICU, manj pogost in tudi z delirijem povezani neželeni učinki pri prejemanju deksmedetomidina so bili manj pogosti kot pri propofolu.
English: Uncommon: Hallucination Cardiac disorders Very common: Bradycardia1,2 Common:
Slovenian: Zelo pogosti: bradikardija1,2 Pogosti:
English: - if you have recently had a stroke or other serious condition affecting blood supply to the brain.
Slovenian: - če imate zelo nizek krvni tlak, ki se ne izboljša z zdravljenjem, - če ste pred kratkim doživeli kap ali drugo resno stanje, ki vpliva na oskrbo možganov s krvjo.
English: In the rabbit study intravenous administration of the maximum dose, 96 µg/kg/day, produced exposures that are similar to those observed clinically.
Slovenian: V študiji pri kuncih so z intravenskim dajanjem največjega odmerka 96 µg/kg/dan dosegli stopnjo izpostavljenosti v okviru razpona kliničnih izpostavljenosti.
English: Sedation of adult ICU (Intensive Care Unit) patients The most frequently reported adverse reactions with dexmedetomidine in ICU setting are hypotension, hypertension and bradycardia, occurring in approximately 25%, 15% and 13% of patients respectively.
Slovenian: Najpogosteje poročani neželeni učinki pri uporabi deksmedetomidina na oddelkih za intenzivno nego so hipotenzija, ki se pojavlja pri približno 25 % bolnikov, hipertenzija, ki se pojavlja pri približno 15 % bolnikov in bradikardija, ki se pojavlja pri približno 13 % bolnikov.
English: Procedural sedation/awake sedation
Slovenian: Proceduralna sedacija/sedacija pri ohranjeni zavesti
English: The risk difference in proportion of subjects randomised to dexmedetomidine not requiring rescue midazolam was 43% (95% CI: 23 % - 57%) compared placebo.
Slovenian: Razlika v tveganju za delež bolnikov, randomiziranih v skupino z deksmedetomidinom, ki niso potrebovali rešilnega midazolama, je bila v primerjavi s skupino s placebom 43 % (95 % IZ: 23 % - 57 %).
English: Common (affects 1 to 10 users in 100) - chest pain or heart attack - fast heart rate - low or high blood sugar - nausea, vomiting or dry mouth - restlessness - high temperature - symptoms after stopping the medicine
Slovenian: - nizek ali visok krvni sladkor - slabost, bruhanje ali suha usta - nemir - visoka temperatura - simptomi po prenehanju jemanja zdravila
English: Care should be taken if combining dexmedetomidine with other substances with sedative or cardiovascular actions as additive effects may occur.
Slovenian: Pri sočasni uporabi deksmedetomidina z drugimi učinkovinami, ki imajo sedativno ali srčno-žilno delovanje, je potrebna previdnost, ker se lahko pojavijo aditivni učinki.
English: Respiration should be monitored in non-intubated patients due to the risk of respiratory depression and in some case apnoea (see section 4.8).
Slovenian: Pri vseh bolnikih je treba med infundiranjem zdravila Dexdor izvajati neprekinjeno spremljanje delovanja srca, pri neintubiranih pa je treba spremljati tudi dihanje zaradi tveganja za nastanek depresije dihanja in v nekaterih primerih apneje (glejte poglavje 4.8).
English: The median (range) midazolam rescue dose was 1.5 (0.5-7.0) mg in the dexmedetomidine1.0 µg/kg group, 2.0 (0.5-8.0) mg in the dexmedetomidine 0.5 µg/kg group, and 4.0 (0.5-14.0) mg in the placebo group.
Slovenian: Mediana vrednost rešilnega odmerka midazolama je bila 1,5 mg (razpon: 0,5-7,0 mg) v skupini, ki je prejemala deksmedetomidinom v odmerku 1,0 μg/kg, 2,0 mg (razpon: 0,5-8,0 mg) v skupini, ki je prejemala 0,5 μg/kg deksmedetomidina, in 4,0 mg (razpon: 0,5-14,0 mg) v skupini s placebom.
English: Dexmedetomidine has analgesic and anaesthetic/analgesic-sparing effects.
Slovenian: Deksmedetomidin ima analgetično in anestetično delovanje oziroma zmanjša potrebno količino analgetika.
English: Hyperglycaemia, hypoglycaemia Uncommon: Metabolic acidosis, hypoalbuminaemia
Slovenian: presnovna acidoza, hipoalbuminemija
English: Dexdor must be administered only as a diluted intravenous infusion using a controlled infusion device.
Slovenian: Zdravilo Dexdor se sme uporabljati le v obliki razredčene intravenske infuzije s pomočjo pripomočka za nadzorovano infundiranje.
English: Maintenance of Procedural Sedation:
Slovenian: Vzdrževanje sedacije pri ohranjeni zavesti:
English: What Dexdor contains
Slovenian: Kaj vsebuje zdravilo Dexdor
English: Approximately 28% of the urinary metabolites are unidentified minor metabolites.
Slovenian: V urinu so izmerili manj kot 1 % nespremenjene učinkovine, približno 28 % presnovkov v urinu pa predstavljajo neopredeljeni, manj pomembni presnovki.
English: Caution should be exercised when administering dexmedetomidine to patients with pre-existing bradycardia.
Slovenian: Pri uporabi deksmedetomidina pri bolnikih z obstoječo bradikardijo je potrebna previdnost.
English: Study 2 randomised patients undergoing awake fibreoptic intubation under topical anaesthesia to receive a loading infusion of dexmedetomidine 1 µg/kg (n=55) or placebo (normal saline) (n=50) given over 10 minutes and followed by a fixed maintenance infusion of 0.7 µg/kg/h.
Slovenian: Študija 2: randomizirani bolniki, ki so bili podvrženi fiberoptični intubaciji pri ohranjeni zavesti pod lokalno anestezijo, so prejeli udarno infuzijo deksmedetomidina 1 μg/kg (n=55) ali infuzijo placeba (fiziološka raztopina) (n=50), ki je bila aplicirana v 10 minutah.
English: Additional analgesia or sedatives (e.g. opioids, midazolam, or propofol) are recommended in case of painful procedures or if increased depth of sedation is necessary.
Slovenian: Pri bolečih postopkih ali v primeru potrebe po globlji sedaciji se priporoča dodatna analgezija ali uporaba dodatnih sedativov (npr. opioidov, midazolama ali propofola).
English: The time to recovery ranged from a short time after discontinuation of dexmedetomidine, to some days later.
Slovenian: Do okrevanja je prišlo hitro po prekinitvi zdravljenja z deksmedetomidinom oziroma nekaj dni po njej, pri večini pa v 12 urah.
English: The most abundant circulating dexmedetomidine metabolites are two isomeric Nglucuronides.
Slovenian: Presnovka deksmedetomidina, ki sta v krvi navzoča v največjih količinah, sta dva izomerna N-glukuronida.
English: Dexdor should be administered by healthcare professionals skilled in the management of patients requiring intensive care or in the anaesthetic management of patients in the operating room.
Slovenian: Zdravilo Dexdor smejo uporabljati le zdravstveni delavci, ki so izurjeni za zdravljenje bolnikov na intenzivni negi ali za anesteziološko obravnavo bolnika v operacijski sobi.
English: Pharmacotherapeutic group: Psycholeptics, other hypnotics and sedatives, ATC code: N05CM18
Slovenian: Farmakoterapevtska skupina: Psiholeptiki, drugi hipnotiki in sedativi, oznaka ATC: N05CM18 Deksmedetomidin je selektiven agonist receptorjev alfa-2 s širokim razponom farmakoloških lastnosti.
English: The mean estimate of the terminal elimination half-life (t1/2) is approximately 1.9 to 2.5 h (min 1.35, max 3.68 h) and the mean estimate of the steady-state volume of distribution (Vss) is approximately 1.16 to 2.16 l/kg (90 to 151 litres).
Slovenian: 3,68 ure), srednji ocenjeni porazdelitveni volumen v ravnovesnem stanju (Vss) pa je približno 1,16 do 2,16 l/kg (90 do 151 litrov).