FrancophonIA/ELRC3.0 huggingface dataset:
English: This syndrome is a granulomatous inflammatory disorder affecting the eyes, auditory system, meninges, and skin.
Croatian: Taj sindrom je granulomatozni upalni poremećaj koji zahvaća oči, slušni sustav, moždane ovojnice i kožu.
English: Anaemia, neutropenia
Croatian: anemija, neutropenija
English: Genotype 2/3 88.9 (72/81) 73.6 (53/72)
Croatian: Genotip 2/3 88,9 (72/81) 73,6 (53/72)
English: In general, patients infected with genotype 4 are considered harder to treat and limited study data (n=66) indicate they are compatible with a duration of treatment with bitherapy as for genotype 1.
Croatian: Općenito se smatra da se bolesnici inficirani genotipom 4 teže liječe, a ograničeni podaci iz ispitivanja (n=66) pokazuju da ih je primjereno liječiti dvojnom terapijom jednako dugo kao kod genotipa 1.
English: If discolouration or particulate matter is present, the reconstituted solution should not be used.
Croatian: Ako je promijenila boju ili su prisutne čestice, rekonstituirana otopina se ne smije upotrijebiti.
English: Following single doses of ViraferonPeg between 0.25 and 2.0 micrograms/kg/week, serum neopterin concentration was increased in a dose-related manner.
Croatian: Nakon primjene pojedinačnih doza lijeka ViraferonPeg između 0,25 i 2,0 mikrograma/kg na tjedan, serumska koncentracija neopterina povećala se proporcionalno dozi.
English: Your healthcare provider will instruct you on how to give the injections.
Croatian: Zdravstveni radnik će Vam dati upute o tome kako primijeniti injekciju.
English: In patients co-infected with HCV/HIV, limited efficacy and safety data (N = 25) are available in subjects with CD4 counts less than 200 cells/µl.
Croatian: Među bolesnicima istodobno zaraženima HCV-om i HIV-om malo je podataka o djelotvornosti i sigurnosti (N=25) za ispitanike s brojem CD4 stanica manjim od 200 stanica/µl.
English: There are no adequate data from the use of interferon alfa-2b in pregnant women.
Croatian: Nema odgovarajućih podataka o primjeni interferona alfa-2b u trudnica.
English: Dispose of the syringe and needles safely in a closed container.
Croatian: Štrcaljku i igle treba odložiti na siguran način u zatvoren spremnik.
English: Cardiomyopathy, that may be reversible upon discontinuation of interferon alpha, has been reported rarely in patients without prior evidence of cardiac disease.
Croatian: Kardiomiopatija, koja se može povući nakon obustave interferona alfa, prijavljena je rijetko u bolesnika u kojih nije bilo utvrđeno postojanje srčane bolesti.
English: In the treatment phase of this study, the most prevalent adverse reactions in all subjects were pyrexia (80 %), headache (62 %), neutropenia (33 %), fatigue (30 %), anorexia (29 %) and injection-site erythema (29 %).
Croatian: U fazi liječenja u sklopu ovoga ispitivanja nuspojave koje su se najčešće pojavljivale u svih ispitanika bile su pireksija (80%), glavobolja (62%), neutropenija (33%), umor (30%), anoreksija (29%) i eritem na mjestu injiciranja (29%).
English: Concomitant administration of peginterferon alfa-2b (ViraferonPeg) with caffeine or desipramine modestly increased the exposure of caffeine and desipramine.
Croatian: Istodobna primjena peginterferona alfa-2b (ViraferonPeg) s kofeinom ili dezipraminom umjereno povećava izloženost kofeinu i dezipraminu.
English: Severe adverse reactions were reported in 7 % (8/107) of all subjects and included injection site pain (1 %), pain in extremity (1 %), headache (1 %), neutropenia (1 %), and pyrexia (4 %).
Croatian: Teške nuspojave prijavljene su u 7% svih ispitanika (8/107) i uključivale su bol na mjestu injiciranja (1%), bol u udovima (1%), glavobolju (1%), neutropeniju (1%) i pireksiju (4%).
English: Any subject with missing data in and after the follow-up week 12 window was considered to be a non-responder at week 24 of follow-up.
Croatian: Za sve ispitanike s nepotpunim podacima tijekom i nakon 12. tjedna praćenja smatralo se da nisu odgovorili u 24. tjednu praćenja.
English: • Genotype 2 or 3:
Croatian: • Genotipovi 2 ili 3:
English: - Inject the solvent SLOWLY, aiming the stream of liquid at the glass wall of the vial.
Croatian: - Ubrizgajte otapalo POLAGANO, usmjeravajući mlaz tekućine na staklenu stijenku bočice.
English: Exacerbation of anaemia due to ribavirin has been reported when zidovudine is part of the regimen used to treat HIV, although the exact mechanism remains to be elucidated.
Croatian: Egzacerbacija anemije uzrokovana ribavirinom prijavljena je u slučajevima kad je u režim liječenja HIV infekcije bio uključen zidovudin, međutim, točan mehanizam još treba razjasniti.
English: During combination therapy for up to 48 weeks with ViraferonPeg and ribavirin, growth inhibition was observed that resulted in reduced height in some patients (see section 4.4).
Croatian: Tijekom kombinirane terapije lijekom ViraferonPeg i ribavirinom u razdoblju do 48 tjedana zabilježen je zastoj u rastu, koji je u nekih bolesnika rezultirao smanjenom visinom (vidjeti dio 4.4).
English: Study 2 (P02080) was a randomized, single centre study that enrolled 95 previously untreated adult patients with chronic hepatitis C who were co-infected with HIV.
Croatian: Ispitivanje 2 (P02080) bilo je randomizirano ispitivanje u jednom centru u koje je uključeno 95 prethodno neliječenih odraslih bolesnika s kroničnim hepatitisom C koji su istodobno bili zaraženi HIV-om.
English: Male patients or their female partners must use an effective contraceptive during treatment and for 7 months after treatment has been concluded (see ribavirin SmPC).
Croatian: Muški bolesnici ili njihove partnerice moraju koristiti učinkovitu kontracepciju tijekom liječenja i 7 mjeseci nakon završetka liječenja (vidjeti Sažetak opisa svojstava lijeka za ribavirin).
English: In addition, dry mouth could have a damaging effect on teeth and mucous membranes of the mouth during long-term treatment with the combination of ViraferonPeg and ribavirin.
Croatian: Uz to, i suhoća usta može štetno djelovati na zube i sluznicu usta tijekom dugotrajne kombinirane terapije lijekom ViraferonPeg i ribavirinom.
English: Overall, approximately 36 % (821/2,286) of patients had undetectable plasma HCV-RNA levels at week 12 of therapy measured using a research-based test (limit of detection 125 IU/ml).
Croatian: Ukupno je HCV-RNK u plazmi bila nemjerljiva u oko 36% (821/2286) bolesnika u 12. tjednu liječenja, mjereno pomoću testa temeljenog na istraživanju (granica detekcije 125 IU/ml).
English: Females of childbearing potential must use an effective contraceptive during treatment and for 4 months after treatment has been concluded.
Croatian: Žene generativne dobi moraju koristiti učinkovitu kontracepciju tijekom liječenja i 4 mjeseca nakon završetka liječenja.
English: Interferons exert their cellular activities by binding to specific membrane receptors on the cell surface.
Croatian: Interferoni u stanicama djeluju vezivanjem za specifične membranske receptore na površini stanice.
English: Suicidal ideation §, suicide attempt
Croatian: §, pokušaj samoubojstva
English: Only 5 children and adolescents with Genotype 4 were treated in the ViraferonPeg/ribavirin clinical trial.
Croatian: Samo je petero djece i adolescenata s genotipom 4 liječeno u kliničkom ispitivanju kombinacije ViraferonPeg/ribavirin.
English: If the chest X-ray shows pulmonary infiltrates or there is evidence of pulmonary function impairment, the patient is to be monitored closely, and, if appropriate, discontinue interferon alpha.
Croatian: Ako se na rendgenskoj snimci pluća otkriju plućni infiltrati ili se dokaže oštećenje plućne funkcije, bolesnika se mora pomno nadzirati te po potrebi obustaviti liječenje interferonom alfa.
English: ViraferonPeg should therefore not be used as long term maintenance monotherapy.
Croatian: Stoga se ViraferonPeg ne smije primjenjivati u dugotrajnoj monoterapiji održavanja.
English: Genotype 2,
Croatian: Genotip 2,
English: Dose reduction of ViraferonPeg in children and adolescents is accomplished by modifying the recommended dose in a two-step process from the original starting dose of 60 g/m 2/week, to 40 g/m 2/week, then to 20 g/m 2/week, if needed.
Croatian: Smanjivanje doze lijeka ViraferonPeg u djece i adolescenata postiže se prilagodbom preporučene doze u dva koraka: od početne doze od 60 μg/m 2 na tjedan na 40 μg/m 2 na tjedan, a zatim na 20 μg/m 2 na tjedan, ako je potrebno.
English: When administered in combination with other interferon preparations, effect of immunosuppressive therapy may be weakened in transplant (kidney, bone marrow, etc.) patients.
Croatian: Kada se primjenjuje u kombinaciji s drugim interferonskim pripravcima, učinak imunosupresivne terapije u bolesnika s transplantiranim organom (bubreg, koštana srž i dr.) može biti oslabljen.
English: Upon multiple dosing, there is an accumulation of immunoreactive interferons.
Croatian: Nakon višekratnog doziranja dolazi do kumulacije imunoreaktivnih interferona.
English: Ocular changes
Croatian: Očne promjene
English: The active substance in this medicine is a protein called peginterferon alfa-2b, which belongs to the class of medicines called interferons.
Croatian: Djelatna tvar u ovom lijeku je protein peginterferon alfa-2b, koji pripada skupini lijekova koji se nazivaju interferoni.
English: The most common treatment-related adverse reactions reported during clinical trials with ViraferonPeg in combination with ribavirin in adults, seen in more than half of the study subjects, were fatigue, headache, and injection site reaction.
Croatian: Najčešće nuspojave prijavljene u kliničkim ispitivanjima, povezane s liječenjem lijekom ViraferonPeg u kombinaciji s ribavirinom u odraslih bolesnika i opažene u više od polovice ispitanika, bile su umor, glavobolja i reakcije na mjestu injiciranja.
English: Case by case benefit/risk assessment in children The expected benefit of treatment should be carefully weighed against the safety findings observed for children and adolescents in the clinical trials (see sections 4.8 and 5.1).
Croatian: Procjena omjera koristi i rizika za svako pojedino dijete Očekivanu korist od liječenja treba pažljivo odvagnuti u odnosu na nalaze o sigurnosti primjene u djece i adolescenata zabilježene u kliničkim ispitivanjima (vidjeti dijelove 4.8 i 5.1).
English: 9/l (adults) ≥ 50 x 10
Croatian: 9/l (odrasli) ≥ 50 x 10
English: In a clinical trial with 107 children and adolescent patients (3 to 17 years of age) treated with combination therapy of ViraferonPeg and ribavirin, dose modifications were required in 25 % of patients, most commonly for anaemia, neutropenia and weight loss.
Croatian: U kliničkom ispitivanju sa 107 djece i adolescenata (3 do 17 godina) liječenih kombiniranom terapijom lijekom ViraferonPeg i ribavirinom bilo je potrebno prilagoditi dozu u 25% bolesnika, najčešće zbog anemije, neutropenije i gubitka tjelesne težine.
English: a: Response to treatment was defined as undetectable HCV-RNA at 24 weeks post-treatment lower limit of detection=125IU/ml b: n = number of responders/number of subjects with given genotype, and assigned treatment duration.
Croatian: a: Odgovor na liječenje definiran je kao nemjerljiva HCV-RNK u 24. tjednu nakon liječenja, donja granica detekcije = 125 IU/ml b: n = broj ispitanika koji su odgovorili na liječenje/broj ispitanika s određenim genotipom i dodijeljenim trajanjem liječenja.
English: The clinical incidence of neutralising factors in patients who received ViraferonPeg 0.5 micrograms/kg is 1.1 %.
Croatian: Klinička incidencija neutralizirajućih čimbenika u bolesnika koji su primali ViraferonPeg 0,5 mikrograma/kg iznosi 1,1%.
English: Injection site infection, lower respiratory tract infection
Croatian: infekcija na mjestu injiciranja, infekcija donjih dišnih puteva
English: - It is important to consider that the combination therapy induced a growth inhibition, that resulted in reduced height in some patients.
Croatian: - Važno je uzeti u obzir da kombinirana terapija izaziva zastoj u rastu, koji u nekih bolesnika rezultira smanjenom visinom.
English: Leukocytes
Croatian: Leukociti
English: A large long-term follow-up study enrolled 567 patients after treatment in a prior study with ViraferonPeg (with or without ribavirin).
Croatian: U veliko ispitivanje dugotrajnog praćenja uključeno je 567 bolesnika koji su završili liječenje u nekom od prethodnih ispitivanja lijeka ViraferonPeg (sa ili bez ribavirina).
English: decrease in rate of growth (height and weight for age), - decreases in red blood cells that may cause fatigue, shortness of breath, dizziness.
Croatian: smanjena brzina rasta (visina i težina za dob), - smanjenje broja crvenih krvnih stanica, što može uzrokovati umor, nedostatak zraka, omaglicu.
English: Female: Dysmenorrhoea
Croatian: žene: dismenoreja
English: Proteinuria
Croatian: proteinurija
English: Failure to prior therapy was defined as relapse or non-response (HCV-RNA positive at the end of a minimum of 12 weeks of treatment).
Croatian: Neuspjeh prethodne terapije definiran je kao relaps ili izostanak odgovora (pozitivan nalaz HCV-RNK nakon najmanje 12 tjedana liječenja).
English: Patients with signs or symptoms compatible with autoimmune disorders should be evaluated carefully, and the benefit-risk of continued interferon therapy should be reassessed (see also section 4.4 Thyroid changes and section 4.8).
Croatian: Bolesnike sa znakovima ili simptomima koji odgovaraju autoimunim poremećajima treba pažljivo pregledati te ponovno procijeniti rizike i koristi nastavka terapije interferonom (vidjeti i dio 4.4 Poremećaji štitnjače i dio 4.8).
English: Limited safety data (N= 25) are available in co-infected patients with CD4+ cell counts < 200/µl (see section 4.4).
Croatian: Dostupni su ograničeni podaci o sigurnosti (N=25) za bolesnike s istodobnom infekcijom u kojih je broj CD4+ stanica bio < 200/μl (vidjeti dio 4.4).
English: Uncommon side effects (may affect up to 1 in 100 people): - wanting to harm yourself, - hallucinations,
Croatian: Manje česte nuspojave (mogu se javiti u do 1 na 100 osoba): - želja za samoozljeđivanjem, - halucinacije.
English: - In the subset of patients with genotype 1 infection and low viral load (< 600,000 IU/ml) who become HCV-RNA negative at treatment week 4 and remain HCV-RNA negative at week 24, the treatment could either be stopped after this 24 week treatment course or pursued for an additional 24 weeks (i.e. overall 48 weeks treatment duration).
Croatian: - U podskupini bolesnika s infekcijom genotipa 1 i malim virusnim opterećenjem (< 600 000 IU/ml) koji postanu HCV-RNK negativni u 4. tjednu liječenja i ostanu HCV-RNK negativni u 24. tjednu, liječenje se može ili prekinuti nakon ta 24 tjedna liječenja ili nastaviti tijekom dodatna 24 tjedna (tj. ukupno trajanje liječenja od 48 tjedana).
English: * (HCV-RNA PCR assay, with a lower limit of quantitation of 27 IU/ml) Lack of early virologic response by Treatment week 12 (detectable HCV-RNA with a < 2 log10 reduction from baseline) was a criterion for discontinuation of treatment.
Croatian: * (određivanje HCV-RNK metodom PCR, s donjom granicom kvantifikacije od 27 IU/ml) Izostanak ranog virološkog odgovora u 12. tjednu liječenja (mjerljiva HCV-RNK uz smanjenje za < 2 log10 od početne vrijednosti) bio je kriterij za obustavu liječenja.
English: - Remove the syringe from the wrapping and do not touch the tip of the syringe.
Croatian: - Izvadite štrcaljku iz omota i nemojte dodirivati vrh štrcaljke.
English: Prompt discontinuation of interferon alpha administration and treatment with corticosteroids appear to be associated with resolution of pulmonary adverse events.
Croatian: Čini se da su brz prekid liječenja interferonom alfa i primjena kortikosteroida povezani s povlačenjem plućnih štetnih događaja.
English: Musculoskeletal pain, pain in extremity, back pain
Croatian: mišićno-koštana bol, bol u ekstremitetima, bol u leđima
English: 3 was observed in 4 % (8/194) of patients receiving ViraferonPeg in combination with ribavirin.
Croatian: 3 također u 4% (8/194) bolesnika koji su primali ViraferonPeg u kombinaciji s ribavirinom.
English: In patients of African American origin (which is known to be a poor prognostic factor for HCV eradication), treatment with ViraferonPeg (1.5 µg/kg)/ribavirin combination therapy resulted in a higher sustained virologic response rate compared to ViraferonPeg 1 µg/kg dose.
Croatian: U bolesnika afroameričkog podrijetla (što je poznat slabi prognostički faktor za eradikaciju HCV-a), liječenjem kombinacijom ViraferonPeg (u dozi od 1,5 µg/kg)/ribavirin postignuta je veća stopa trajnog virološkog odgovora u odnosu na primjenu doze lijeka ViraferonPeg od 1 µg/kg.
English: Do not use the solution if it is discoloured (changed its colour from the original) or if there are bits of particles in the solution.
Croatian: Ne koristite otopinu ako je promijenila boju (u odnosu na originalnu) ili sadrži čestice.
English: HCV infected patients having a co-occurring substance use disorder (alcohol, cannabis, etc) are at an increased risk of developing psychiatric disorders or exacerbation of already existing psychiatric disorders when treated with alpha interferon.
Croatian: Bolesnici zaraženi HCV-om koji istodobno uzimaju sredstva ovisnosti (alkohol, kanabis i sl.) izloženi su povećanom riziku za razvoj psihijatrijskih poremećaja ili pogoršanju postojećih psihijatrijskih poremećaja kad se liječe alfa interferonom.
English: ViraferonPeg should be administered as a once weekly subcutaneous injection.
Croatian: ViraferonPeg se primjenjuje supkutanom injekcijom jedanput na tjedan.
English: The potential interaction of peginterferon alfa-2b (ViraferonPeg) on substrates of metabolic enzymes was evaluated in 3 multiple-dose clinical pharmacology studies.
Croatian: Moguća interakcija peginterferona alfa-2b (ViraferonPeg) sa supstratima metaboličkih enzima ocijenjena je u 3 klinička farmakološka ispitivanja s primjenom višekratnih doza.
English: Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, 4.2).
Croatian: Lijek se izdaje na ograničeni recept (vidjeti Prilog I.: Sažetak opisa svojstava lijeka, dio 4.2).
English: - Then insert the needle through the rubber top of the ViraferonPeg vial.
Croatian: - Zatim ubodite iglu kroz gumeni vrh bočice lijeka ViraferonPeg.
English: In this trial, the combination of ViraferonPeg (1.5 micrograms/kg/week) and ribavirin was significantly more effective than the combination of interferon alfa-2b and ribavirin (Table 8), particularly in patients infected with Genotype 1 (Table 9).
Croatian: U ovom je ispitivanju kombinacija lijeka ViraferonPeg (1,5 mikrograma/kg na tjedan) i ribavirina bila značajno djelotvornija od kombinacije interferona alfa-2b i ribavirina (Tablica 8), osobito u bolesnika inficiranih genotipom 1 (Tablica 9).
English: Colitis ulcerative
Croatian: ulcerozni kolitis
English: By extrapolation from clinical data on combination therapy with standard interferon in paediatric patients (negative predictive value 96 % for interferon alfa-2b/ribavirin), patients who fail to achieve virological response at 12 weeks are highly unlikely to become sustained virological responders.
Croatian: Ekstrapolacija iz kliničkih podataka za kombiniranu terapiju sa standardnim interferonom u pedijatrijskih bolesnika (negativna prediktivna vrijednost 96% za interferon alfa-2b/ribavirin) ukazuje da bolesnici koji nisu postigli virološki odgovor u 12. tjednu terapije najvjerojatnije neće postići trajan virološki odgovor.
English: 1.0 g/kg
Croatian: 1,0 µg/kg
English: ViraferonPeg is a well characterized polyethylene glycol-modified (“pegylated”) derivative of interferon alfa-2b and is predominantly composed of monopegylated species.
Croatian: ViraferonPeg je dobro karakteriziran derivat interferona alfa-2b modificiran polietilenglikolom ("pegiliran"), pretežno sastavljen od monopegiliranih vrsta.
English: Myalgia, arthralgia
Croatian: mialgija, artralgija
English: The safety and efficacy of ViraferonPeg therapy has not been evaluated in patients with severe hepatic dysfunction, therefore ViraferonPeg must not be used for these patients.
Croatian: Sigurnost i djelotvornost liječenja lijekom ViraferonPeg nije ispitivana u bolesnika s teškim oštećenjem funkcije jetre te se stoga ViraferonPeg ne smije primjenjivati u tih bolesnika.
English: Gently turn the pre-filled pen up-side-down two times to mix (see Figure 2).
Croatian: Nježno preokrenite napunjenu brizgalicu dva puta da biste promiješali lijek (Vidjeti Sliku 2).
English: What ViraferonPeg contains
Croatian: Što ViraferonPeg sadrži
English: The appropriate dose can then be withdrawn with a sterilised injection syringe and injected.
Croatian: Tada se steriliziranom injekcijskom štrcaljkom može povući odgovarajuća doza lijeka i injicirati.
English: These reactions are listed in Table 7 by system organ class and frequency (very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) or not known (cannot be estimated from the available data).
Croatian: Te su nuspojave navedene u Tablici 7 po organskim sustavima i učestalosti pojavljivanja (vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000) ili nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Depression, anxiety *, emotional lability *, concentration impaired, insomnia
Croatian: depresija, anksioznost*, emocionalna labilnost*, narušena koncentracija, nesanica
English: This study showed that ViraferonPeg was superior to interferon alfa-2b (Table 8).
Croatian: Ovo ispitivanje je pokazalo da je ViraferonPeg superioran interferonu alfa-2b (Tablica 8).
English: Remove the needle guard from the syringe needle and check for air bubbles in the syringe.
Croatian: Skinite štitnik s igle na štrcaljki i provjerite ima li u štrcaljki mjehurića zraka.
English: Patients who develop fatigue, somnolence or confusion during treatment with ViraferonPeg are cautioned to avoid driving or operating machines.
Croatian: Bolesnike koji tijekom liječenja lijekom ViraferonPeg osjete umor, somnolenciju ili konfuziju treba upozoriti da izbjegavaju upravljanje motornim vozilima i rad sa strojevima.
English: Rare side effects (may affect up to 1 in 1,000 people): - convulsion (“fit”), - blood or clots in stool (or black, tarry stool),
Croatian: Rijetke nuspojave (mogu se javiti u do 1 na 1000 osoba): - konvulzije ("napadaji"), - krv ili krvni ugrušci u stolici (ili crna, katranasta stolica).
English: Reports of mitochondrial toxicity, in particular lactic acidosis and pancreatitis, of which some fatal, have been reported (see ribavirin SmPC).
Croatian: Prijavljeni su slučajevi mitohondrijske toksičnosti, osobito laktacidoze i pankreatitisa, od kojih su neki imali smrtni ishod (vidjeti Sažetak opisa svojstava lijeka za ribavirin).
English: HCV-RNA negative
Croatian: HCV-RNK negativna 508
English: ViraferonPeg pharmacodynamics were assessed in a rising single-dose trial in healthy subjects by examining changes in oral temperature, concentrations of effector proteins such as serum neopterin and 2'5'-oligoadenylate synthetase (2'5'-OAS), as well as white cell and neutrophil counts.
Croatian: Farmakodinamika lijeka ViraferonPeg ocijenjena je u ispitivanju u kojemu su zdravim ispitanicima davane sve veće pojedinačne doze lijeka, i to mjerenjem promjena oralne temperature, koncentracije efektornih proteina poput serumskog neopterina i 2'5'-oligoadenilat-sintetaze (2'5'-OAS) te promjena broja leukocita i neutrofila.
English: In those patients that received > 10.6 mg/kg ribavirin (800 mg dose in typical 75 kg patient), regardless of genotype or viral load, response rates were significantly higher than in those patients that received  10.6 mg/kg ribavirin (Table 9), while response rates in patients that received > 13.2 mg/kg ribavirin were even higher.
Croatian: U bolesnika koji su primali > 10,6 mg/kg ribavirina (doza od 800 mg u bolesnika težine 75 kg) je, bez obzira na genotip ili virusno opterećenje, stopa odgovora bila značajno veća nego u onih koji su primali ≤ 10,6 mg/kg ribavirina (Tablica 9), dok je stopa odgovora u bolesnika koji su primali > 13,2 mg/kg ribavirina bila još i veća.