FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients who met the entry criteria and received one or more doses of caspofungin study therapy were included in the efficacy analysis.
Slovenian: V analizo učinkovitosti so vključili bolnike, ki so ustrezali vključitvenim kriterijem in ki so prejeli enega ali več odmerkov kaspofungina tekom študije.
English: The white to off-white compact lyophilised powder will dissolve completely.
Slovenian: Beli do skoraj beli kompaktni liofilizirani prašek se bo popolnoma raztopil.
English: The response rates among patients with pulmonary disease and extrapulmonary disease were 47 % (21/45) and 28 % (5/18), respectively.
Slovenian: Delež odziva na zdravljenje je pri bolnikih s pljučno boleznijo znašal 47 % (21/45), pri bolnikih z zunaj-pljučno boleznijo pa 28 % (5/18).
English: Studies in vitro show that caspofungin is not an inhibitor of any enzyme in the cytochrome P450 (CYP) system.
Slovenian: Študije in vitro kažejo, da kaspofungin ne zavira nobenega od encimov sistema citokrom P450 (CYP).
English: • Decreased flow of bile, enlarged liver, yellowing of the skin and/or whites of the eyes, liver injury caused by a drug or chemical, liver disorder
Slovenian: • zmanjšano izločanje žolča, povečana jetra, porumenitev kože in/ali beločnic v očeh, okvara jeter zaradi zdravil ali kemikalij, motnje v delovanju jeter
English: • If you have any further questions, ask your doctor, nurse or pharmacist.
Slovenian: • Če imate dodatna vprašanja, se posvetujte z zdravnikom, medicinsko sestro ali farmacevtom.
English: dose, the AUC0-24 hr was somewhat higher.
Slovenian: 50 mg/m2, pa je bila AUC0-24h nekoliko večja.
English: In patients weighing more than 80 kg, after the initial 70 mg loading dose, caspofungin 70 mg daily is recommended (see section 5.2).
Slovenian: Pri bolnikih, težjih od 80 kg, po začetnem uvajalnem odmerku 70 mg priporočamo kaspofungin v odmerku 70 mg dnevno (glejte poglavje 5.2).
English: Investigations blood potassium decreased, blood albumin decreased blood creatinine increased, red blood cells urine positive, protein total decreased, protein urine present, prothrombin time prolonged, prothrombin time shortened, blood sodium decreased, blood sodium increased, blood calcium decreased, blood calcium increased, blood chloride decreased, blood glucose increased, blood magnesium decreased, blood phosphorus decreased, blood phosphorus increased, blood urea increased, activated partial thromboplastin time prolonged, blood bicarbonate decreased, blood chloride increased, blood potassium increased, blood pressure increased, blood uric acid decreased, blood urine present, breath sounds abnormal, carbon dioxide decreased, immunosuppressant drug level increased, international normalised ratio increased, urinary casts, white blood cells urine positive, and pH urine increased.
Slovenian: Preiskave znižane vrednosti kalija v krvi, znižane vrednosti albumina v krvi zvišanje kreatinina v krvi, prisotnost eritrocitov v urinu, znižane vrednosti celokupnih beljakovin, prisotnost beljakovin v urinu, podaljšan protrombinski čas, skrajšan protrombinski čas, znižane vrednosti natrija v krvi, zvišane vrednosti natrija v krvi, znižane vrednosti kalcija v krvi, zvišane vrednosti kalcija v krvi, znižane vrednosti klorida v krvi, zvišane vrednosti glukoze v krvi, znižane vrednosti magnezija v krvi, znižane vrednosti fosforja v krvi, zvišane vrednosti fosforja v krvi, zvišane vrednosti sečnine v krvi, podaljšan aktivirani parcialni tromboplastinski čas, znižane vrednosti hidrogenkarbonata v krvi, zvišane vrednosti klorida v krvi, zvišane vrednosti kalija v krvi, zvišanje krvnega tlaka, znižane vrednosti sečne kisline v krvi, prisotnost krvi v urinu, nenormalni zvoki pri dihanju, znižanje ogljikovega dioksida, zvišane vrednosti imunosupresivov, povišano internacionalno normalizirano razmerje, cilindri v urinu, prisotnost levkocitov v urinu in zvišan pH urina.
English: Calculation of Body Surface Area (BSA) for paediatric dosing
Slovenian: Izračun telesne površine za pediatrično odmerjanje
English: 70 mg (from two 50 mg vials)**
Slovenian: 70 mg (iz dveh 50 ml vial)
English: Unopened vials: store in a refrigerator 2°C - 8°C).
Slovenian: Neodprte viale: shranjujte v hladilniku (2 C - 8 C).
English: In a multiple-dose study, a dose reduction of the daily dose to 35 mg in adult patients with moderate hepatic impairment has been shown to provide an AUC similar to that obtained in adult subjects with normal hepatic function receiving the standard regimen (see section 4.2).
Slovenian: V študiji z večkratnimi odmerki je bila AUC pri odraslih bolnikih z zmerno jetrno okvaro po zmanjšanju dnevnega odmerka na 35 mg podobna kot AUC pri odraslih preiskovancih z normalnim delovanjem jeter, ki so dobivali običajen odmerek (glejte poglavje 4.2).
English: People who might get this type of infection include those having chemotherapy, those who have had a transplant and those whose immune systems are weak.
Slovenian: Med tiste, ki bi lahko oboleli za to okužbo, spadajo bolniki, ki prejemajo kemoterapijo, bolniki po transplantaciji ali tisti, ki imajo oslabel imunski sistem.
English: There is no clinical experience in adult patients with severe hepatic impairment and in paediatric patients with any degree of hepatic impairment.
Slovenian: Kliničnih izkušenj pri odraslih bolnikih s hudo jetrno okvaro in pri pediatričnih bolnikih s katerokoli stopnjo jetrne okvare ni.
English: In a second study, patients with invasive candidiasis received daily doses of caspofungin at 50 mg/day (following a 70-mg loading dose on Day 1) or caspofungin at 150 mg/day (see section 4.8).
Slovenian: V drugi študiji so bolniki z invazivno kandidiazo dnevno prejemali kaspofungin v odmerku 50 mg/dan (po uvajalnem odmerku 70 mg na 1. dan) ali 150 mg/dan (glejte poglavje 4.8).
English: Pharmacokinetic data from one 10-month old child receiving the 50 mg/m2 daily dose indicated an AUC0-24 hr within the same range as that observed in older children and adults at the 50 mg/m2 and the 50 mg dose, respectively, while in one 6-month old child receiving the 50 mg/m2
Slovenian: Farmakokinetični podatki so pri enem 10-mesečnem otroku, ki je dobival 50 mg/m2 na dan, pokazali AUC0-24h v enakem območju, kot je bila pri starejših otrocih med uporabo 50 mg/m2 in odraslih med uporabo 50-mg odmerka, pri enem 6-mesečnem otroku, ki je dobival
English: Close monitoring of liver enzymes should be considered if the two medicinal products are used concomitantly.
Slovenian: Pri sočasni uporabi teh dveh zdravil je treba razmisliti o skrbnem spremljanju vrednosti jetrnih encimov.
English: In a retrospective study of 40 patients treated during marketed use with caspofungin and cyclosporin for 1 to 290 days (median 17.5 days), no serious hepatic adverse reactions were noted (see section 4.4).
Slovenian: V retrospektivni študiji pri 40 bolnikih, ki so se med trženjem zdravila zdravili s kaspofunginom in ciklosporinom 1 do 290 dni (mediana 17,5 dni), niso zabeležili resnih neželenih učinkov na jetra (glejte poglavje 4.4).
English: Patients in the caspofungin group experienced breakthrough infections due to the following uncommon yeasts and moulds: Trichosporon species (1), Fusarium species (1), Mucor species (1), and Rhizopus species (1).
Slovenian: Bolniki v kaspofunginski skupini so doživeli izbruh okužbe z naslednjimi redkimi vrstami kvasovk in plesni: Trichosporon (1),
English: • Empirical therapy for presumed fungal infections (such as Candida or Aspergillus) in febrile,
Slovenian: • Empirično zdravljenje domnevnih glivnih okužb (npr. s Candido ali Aspergillusom) pri febrilnih, nevtropeničnih odraslih ali pediatričnih bolnikih.
English: EUCAST breakpoints have not yet been established for caspofungin, due to significant inter-laboratory variation in MIC ranges for caspofungin.
Slovenian: Zaradi znatnih razlik v razponu MIC vrednosti za kaspofungin med različnimi laboratoriji mejne vrednosti EUCAST za kaspofungin še niso bile določene.
English: Caspofungin undergoes spontaneous degradation to an open ring compound.
Slovenian: Kaspofungin se spontano razgradi v spojino z odprtim obročem.
English: • Decreased haemoglobin (decreased oxygen carrying substance in the blood), decreased white blood cells
Slovenian: • zmanjšana vrednost hemoglobina (zmanjšana koncentracija snovi, ki prenaša kisik po krvi),
English: This reconstituted solution may be stored for up to 24 hours at or below 25°C.
Slovenian: Tako pripravljeno raztopino lahko shranite za največ 24 ur pri temperaturi 25 C ali manj.
English: • Tightening of the bands of muscle around the airways resulting in wheezing or coughing, fast breathing rate, shortness of breath that wakes you up, shortage of oxygen in the blood, abnormal breath sounds, crackling sounds in the lungs, wheezing, nasal congestion, cough, throat pain
Slovenian: • piskanje in kašljanje, do katerega pride zaradi zategovanja mišic okrog dihalnih poti, pospešeno dihanje, kratka sapa, ki vas zbudi, pomanjkanje kisika v krvi, nenavadni zvoki pri dihanju, prasketajoči zvoki v pljučih, piskanje, zamašen nos, kašelj, boleče grlo
English: For all indications, a single 70-mg/m2 loading dose (not to exceed an actual dose of 70 mg) should be administered on Day 1, followed by 50 mg/m2 daily thereafter (not to exceed an actual dose of 70 mg daily).
Slovenian: Za vse indikacije je treba 1. dan uporabiti en uvajalni odmerek 70 mg/m2 (vendar absolutni odmerek ne sme preseči 70 mg), čemur sledi uporaba 50 mg/m2 dnevno (pri čemer absolutni odmerek ne sme preseči 70 mg na dan).
English: • Changes in some laboratory blood tests (increased values of some liver tests)
Slovenian: • spremembe nekaterih laboratorijskih izvidov krvi (povečanje vrednosti nekaterih jetrnih testov)
English: Caspofungin reduced the trough concentration of tacrolimus by 26 % in healthy adult volunteers.
Slovenian: Kaspofungin je pri zdravih odraslih prostovoljcih zmanjšal koncentracijo takrolimusa, izmerjeno tik pred naslednjim odmerkom, za 26 %.
English: However, paediatric patients probably have a different adverse event profile compared to adult patients.
Slovenian: Vendar pa je profil neželenih učinkov pri pediatričnih bolnikih drugačen kot pri odraslih.
English: In paediatric patients, results from regression analyses of pharmacokinetic data suggest that co-administration of dexamethasone with caspofungin may result in clinically meaningful reductions in caspofungin trough concentrations.
Slovenian: Rezultati regresijske analize farmakokinetičnih podatkov pri pediatričnih bolnikih kažejo, da lahko sočasna uporaba deksametazona in kaspofungina klinično pomembno zmanjša koncentracijo kaspofungina, izmerjeno tik pred naslednjim odmerkom.
English: PHARMACEUTICAL FORM AND CONTENTS Powder for concentrate for solution for infusion.
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA prašek za koncentrat za raztopino za infundiranje 1 viala
English: Alternatively, the volume (mL)c of reconstituted
Slovenian: Druga možnost je, da količino (ml)c pripravljene raztopine zdravila
English: Day 1 [not to exceed 70 mg daily]) to liposomal amphotericin B (3 mg/kg IV daily) in a 2:1 treatment fashion (56 on caspofungin, 26 on liposomal amphotericin B) as empirical therapy in paediatric patients with persistent fever and neutropenia.
Slovenian: na dan) v razmerju zdravljenja 2:1 (56 na kaspofunginu, 26 na liposomskem amfotericinu B) kot empirično zdravljenje pediatričnih bolnikov z dolgotrajno zvišano telesno temperaturo in nevtropenijo.
English: • The other ingredients are sucrose, mannitol, succinic acid and sodium hydroxide (please see section 2.
Slovenian: • Druge sestavine zdravila so: saharoza, manitol, jantarna kislina in natrijev hidroksid (prosimo,
English: Similarly, C. parapsilosis isolates intermediate to anidulafungin and micafungin can be regarded intermediate to caspofungin.
Slovenian: Podobno se izolate C. parapsilosis, intermediarne za anidulafungin in mikafungin, upošteva kot intermediarne za kaspofungin.
English: Hepatobiliary disorders elevated liver values (alanine aminotransferase, aspartate aminotranserase, blood alkaline phosphatase, bilirubin conjugated, blood bilirubin)
Slovenian: Bolezni jeter, žolčnika in žolčevodov zvišane vrednosti jetrnih testov (alanin aminotransferaze, aspartat aminotransferaze, alkalne fosfataze v krvi, konjugiranega bilirubina, bilirubina v krvi)
English: The concentrations of the reconstituted vials will be 7.2 mg/mL.
Slovenian: Koncentracija pripravljenega koncentrata bo 7,2 mg/ml.
English: In some adult and paediatric patients with serious underlying conditions who were receiving multiple concomitant medications with caspofungin, cases of clinically significant hepatic dysfunction, hepatitis and hepatic failure have been reported; a causal relationship to caspofungin has not been established.
Slovenian: Pri nekaterih odraslih in pediatričnih bolnikih z resnimi že obstoječimi boleznimi, ki so sočasno s kaspofunginom prejemali več zdravil, so poročali o primerih klinično pomembne motnje delovanja jeter, hepatitisa in odpovedi jeter.
English: Caspofungin displays moderate non-linear pharmacokinetics with increased accumulation as the dose is increased, and a dose dependency in the time to reach steady state upon multiple-dose administration.
Slovenian: Kaspofungin kaže zmerno nelinearno farmakokinetiko s povečanim kopičenjem ob povečanem odmerku.
English: In clinical studies, caspofungin did not induce or inhibit the CYP3A4 metabolism of other medicinal products.
Slovenian: V kliničnih študijah kaspofungin ni induciral ali zaviral presnove drugih zdravil z encimom CYP3A4.
English: Metabolism and nutrition disorders hypokalemia fluid overload, hypomagnesaemia, anorexia, electrolyte imbalance, hyperglycaemia, hypocalcaemia, metabolic acidosis
Slovenian: Presnovne in prehranske motnje hipokaliemija preobremenitev s tekočino, hipomagneziemija, anoreksija, motnje ravnovesja elektrolitov, hiperglikemija, hipokalciemija, metabolična acidoza
English: • Blurred vision, increase in tears, swollen eyelid, yellowing of the whites of the eyes
Slovenian: • zamegljen vid, povečano solzenje, otekanje veke, porumenitev beločnice v očeh
English: The study compared caspofungin at 50 mg daily (following a 70-mg loading dose on Day 1) versus 150 mg daily in the treatment of invasive candidiasis.
Slovenian: V študiji so primerjali odmerka 50 mg kaspofungina na dan (po uvajalnem odmerku 70 mg na 1. dan) in 150 mg kaspofungina na dan pri zdravljenju invazivne kandidiaze.
English: If not used immediately, in use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2 to 8°C, unless reconstitution and dilution have taken place in controlled validated aseptic conditions.
Slovenian: Normalno naj ta čas ne bi bil daljši od 24 ur, če raztopino shranjujemo pri temperaturi 2 do 8 °C, razen če sta priprava in razredčenje potekala v kontroliranih, validiranih aseptičnih pogojih.
English: • Back pain, pain in an arm or leg, bone pain, muscle pain, muscle weakness
Slovenian: • bolečina v hrbtu, bolečina v rokah in nogah, bolečina v kosteh, bolečina v mišicah, šibkost mišic
English: Cardiac disorders palpitations, tachycardia, arrhythmia, atrial fibrillation, cardiac failure congestive
Slovenian: Srčne bolezni palpitacije, tahikardija, aritmija, atrijska fibrilacija, kongestivno srčno popuščanje
English: Nervous system disorders headache dizziness, dysgeusia, paraesthesia, somnolence, tremor, hypoaesthesia
Slovenian: Bolezni živčevja glavobol omotica, disgevzija, parestezija, zaspanost, tremor, hipestezija
English: a. The white to off-white cake will dissolve completely.
Slovenian: a. Bela do skoraj bela pogača se bo povsem raztopila.
English: Response rates to caspofungin and liposomal amphotericin B for baseline infections caused by Aspergillus species were, respectively, 41.7 % (5/12) and 8.3 % (1/12), and by Candida species were 66.7 % (8/12) and 41.7 % (5/12).
Slovenian: Pri osnovnih okužbah z vrsto Aspergillus je bil delež odziva na kaspofungin 41,7 % (5/12) in na liposomski amfotericin B 8,3 % (1/12), pri osnovnih okužbah z vrsto Candida pa na kaspofungin 66,7 % (8/12) in na liposomski amfotericin B 41,7 % (5/12).
English: The concentrations of the reconstituted vials will be 5.2 mg/mL.
Slovenian: Koncentracija pripravljenega koncentrata bo 5,2 mg/ml.
English: Favourable response rates in neutropaenic patients were 7/14 (50 %) in the caspofungin group and 4/10 (40 %) in the amphotericin B group.
Slovenian: Delež ugodnega odziva pri nevtropeničnih bolnikih je bil med prejemniki kaspofungina 7/14 (50 %) in med prejemniki amfotericina B 4/10 (40 %).
English: Eligible patients had received chemotherapy for malignancy or had undergone hematopoietic stem-cell transplantation, and presented with neutropaenia (<500 cells/mm3 for 96 hours) and fever (>38.0°C)
Slovenian: Za študijo ustrezni bolniki so dobivali kemoterapijo zaradi malignoma ali so prestali presaditev hematopoetskih matičnih celic ter so imeli nevtropenijo (< 500 celic/mm3 96 ur) in zvišano telesno temperaturo (> 38.0 °C), ki se nista odzivali na ≥ 96-urno parenteralno protibakterijsko terapijo.
English: Reduced volume infusion (reconstituted Caspofungin Accord added to 100 mL) final concentration
Slovenian: Manjša prostornina infuzije (koncentrat zdravila Kaspofungin Accord dodan v 100 ml) končna koncentracija
English: In clinical studies, caspofungin did not induce the CYP3A4 metabolism of other substances.
Slovenian: V kliničnih študijah kaspofungin ni induciral presnove drugih snovi z encimom CYP3A4.
English: Determine the actual daily maintenance dose to be used in the paediatric patient by using the patient's BSA (as calculated above) and the following equation:
Slovenian: Dejanski dnevni vzdrževalni odmerek za pediatričnega bolnika določite na podlagi njegove telesne površine (izračunane, kot je prikazano zgoraj) po naslednji enačbi:
English: • Feeling dizzy, decreased feeling or sensitivity (especially in the skin), shaking, feeling sleepy, change in the way things taste, tingling or numbness
Slovenian: • omotica, zmanjšan občutek dotika ali zmanjšana občutljivost (predvsem na koži), tresenje, zaspanost, motnje okušanja, mravljinčenje ali odrevenelost
English: • Chest discomfort, chest pain, feeling of body temperature change, generally feeling unwell, general pain, swelling of the face, swelling of the ankles, hands or feet, swelling, tenderness, feeling tired.
Slovenian: • nelagodje v prsnem košu, bolečina v prsnem košu, občutek spremembe telesne temperature, splošno slabo počutje, splošna bolečina, otekanje obraza, otekanje gležnjev, dlani ali stopal, otekanje, občutljivost, utrujenost
English: • rash, skin peeling, mucous membrane sores, hives, large areas of peeling skin.
Slovenian: • izpuščaj, luščenje kože, rane na sluznici, koprivnico, večja področja luščenja kože.
English: Caspofungin Accord contains a medicine called caspofungin.
Slovenian: Zdravilo Kaspofungin Accord vsebuje zdravilno učinkovino kaspofungin.
English: Clinical studies in healthy adult volunteers show that the pharmacokinetics of caspofungin are not altered to a clinically relevant extent by itraconazole, amphotericin B, mycophenolate, nelfinavir, or tacrolimus.
Slovenian: Klinične študije pri zdravih odraslih prostovoljcih kažejo, da itrakonazol, amfotericin B, mikofenolat, nelfinavir in takrolimus farmakokinetike kaspofungina ne spremenijo v klinično pomembni meri.
English: Diluted patient infusion solution: should be used immediately.
Slovenian: Razredčeno raztopino za infundiranje je treba uporabiti takoj.
English: Do not use Caspofungin Accord
Slovenian: Ne uporabljajte zdravila Kaspofungin Accord:
English: Each vial of Caspofungin Accord contains 50 mg or 70 mg of caspofungin (as acetate).
Slovenian: Ena viala zdravila Kaspofungin Accord vsebuje 50 mg ali 70 mg kaspofungina (v obliki acetata).
English: Musculoskeletal and connective tissue disorders arthralgia back pain, pain in extremity, bone pain, muscular weakness, myalgia
Slovenian: Bolezni mišičnoskeletnega sistema in vezivnega tkiva artralgija bolečina v hrbtu, bolečina v okončinah, bolečina v kosteh, šibkost mišic, mialgija
English: Hepatic impairment: In adult patients with mild and moderate hepatic impairment, the AUC is increased about 20 and 75 %, respectively.
Slovenian: Okvara jeter: Pri odraslih bolnikih z blago jetrno okvaro se AUC poveča za približno 20 %, pri odraslih bolnikih z zmerno jetrno okvaro pa za približno 75 %.
English: • Catheter site pain, injection site complaints (redness, hard lump, pain, swelling, irritation, rash, hives, leaking of fluid from the catheter into the tissue), inflammation of vein at injection site
Slovenian: • bolečina na mestu vstavljenega katetra, zapleti na mestu injiciranja (rdečina, otrdlina, bolečina, otekanje, draženje, izpuščaj, koprivnica, uhajanje tekočine iz katetra v tkivo), vnetje vene na mestu injiciranja,
English: • Diarrhoea, nausea or vomiting
Slovenian: • driska, siljenje na bruhanje ali bruhanje
English: Although safety data are limited it appears that no special precautions are needed when amphotericin B, itraconazole, nelfinavir or mycophenolate mofetil are co-administered with caspofungin.
Slovenian: Čeprav je podatkov o varnosti malo, kaže, da med sočasno uporabo kaspofungina z amfotericinom B, itrakonazolom, nelfinavirjem ali mofetilmikofenolatom niso potrebni posebni previdnostni ukrepi.
English: Of these, 37 had invasive candidiasis, 10 had invasive aspergillosis, and 1 patient had esophageal candidiasis.
Slovenian: enkrat na dan; 48 bolnikov je bilo vključenih v analizo MITT. Od teh jih je 37 imelo invazivno kandidiazo, 10 invazivno aspergilozo in 1 bolnik ezofagealno kandidiazo.
English: Limited data suggest that caspofungin at 25 mg/m2 daily in neonates and infants (less than 3 months of age) and 50 mg/m2 daily in young children (3 to 11 months of age) can be considered (see section 5.2).
Slovenian: Malo podatkov nakazuje, da pride pri novorojenčkih in dojenčkih (starih manj kot 3 mesece) v poštev zdravljenje s kaspofunginom v odmerku 25 mg/m2 na dan, pri majhnih otrocih (starih od 3 do 11 mesecev) pa v odmerku 50 mg/m2 na dan (glejte poglavje 5.2).
English: Psychiatric anxiety, disorientation, insomnia disorders
Slovenian: Psihiatrične motnje anksioznost, zmedenost, nespečnost
English: A single 70 mg loading dose should be administered on Day-1, followed by 50 mg daily thereafter.
Slovenian: Prvi dan je potreben en uvajalni odmerek 70 mg, ki mu nato sledijo odmerki 50 mg dnevno.
English: Instructions of how to reconstitute and dilute Caspofungin Accord:
Slovenian: Navodilo za pripravo in razredčevanje zdravila Kaspofungin Accord:
English: When caspofungin is co-administered to paediatric patients (12 months to 17 years of age) with these same inducers of metabolic enzymes (see section 4.5), a caspofungin dose of 70-mg/m2 daily (not to exceed an actual daily dose of 70 mg)
Slovenian: Če se kaspofungin uporablja pri pediatričnih bolnikih (starih od 12 mesecev do 17 let) sočasno s temi induktorji presnovnih encimov (glejte poglavje 4.5), je treba razmisliti o uporabi kaspofungina v odmerku 70 mg/m2 na dan (pri čemer pa absolutni dnevni odmerek ne sme preseči 70 mg).
English: Excipients: sucrose, mannitol, succinic acid and sodium hydroxide.
Slovenian: Pomožne snovi: saharoza, manitol, jantarna kislina in natrijev hidroksid.
English: Weight: Weight was found to influence caspofungin pharmacokinetics in the population pharmacokinetic analysis in adult candidiasis patients.
Slovenian: Telesna masa: V populacijski farmakokinetični analizi pri odraslih bolnikih s kandidiazo so ugotovili, da telesna masa vpliva na farmakokinetiko kaspofungina.
English: INSTRUCTIONS FOR USE IN ADULT PATIENTS (Caspofungin Accord 70 mg) Step 1 Reconstitution of conventional vials
Slovenian: NAVODILA ZA UPORABO PRI ODRASLIH BOLNIKIH (Kaspofungin Accord 70 mg) 1. korak: Priprava koncentrata
English: • Fever
Slovenian: • mrzlica
English: Caspofungin trough levels gradually decreased upon repeated administration.
Slovenian: Koncentracije kaspofungina, izmerjene tik pred naslednjim odmerkom, so se po ponavljajočih odmerkih postopoma zmanjšale.
English: 50 mg at reduced volume
Slovenian: 50 mg / zmanjšana prostornina infuzije 10 ml