FrancophonIA/ELRC3.0 huggingface dataset:
English: In the 3.5 year PROactive study, 44/870 (5.1%; 1.0 fractures per 100 patient years) of pioglitazone-treated female patients experienced fractures compared to 23/905 (2.5%; 0.5 fractures per 100 patient years) of female patients treated with comparator.
Croatian: U ispitivanju PROactive u trajanju od 3,5 godine, 44 od 870 (5,1%: 1,0 prijeloma na 100 bolesnik-godina) žena liječenih pioglitazonom imalo je prijelom u usporedbi s 23 od 905 (2,5%: 0,5 prijeloma na 100 bolesnik-godina) žena liječenih komparatorom.
English: If ALT levels are increased to 3 x upper limit of normal during Glubrava therapy, liver enzyme levels should be reassessed as soon as possible.
Croatian: Ako se tijekom terapije lijekom Glubrava vrijednosti ALT povise na vrijednosti koje su > 3 x iznad gornje granice normale, razine jetrenih enzima treba čim prije ponovno provjeriti.
English: In a placebo controlled trial, patients with inadequate glycaemic control despite a three month insulin optimisation period were randomised to pioglitazone or placebo for 12 months.
Croatian: U placebom kontroliranom ispitivanju, bolesnici s neodgovarajućom kontrolom glikemije unatoč tromjesečnom razdoblju optimizacije inzulina bili su randomizirani u skupinu koja je primala pioglitazon i skupinu koja je primala placebo tijekom 12 mjeseci.
English: In a two-year study of combination therapy comparing pioglitazone with gliclazide when added to metformin, glycaemic control measured as mean change from baseline in HbA1c was similar between treatment groups after one year.
Croatian: U dvogodišnjem ispitivanju kombinirane terapije u kojem se pioglitazon uspoređivao s gliklazidom nakon dodavanja metforminu, kontrola glikemije mjerena kao srednja vrijednost promjene HbA1c u odnosu na početnu vrijednost bila je slična u obje terapijske skupine nakon jedne godine.
English: Single dose studies demonstrate linearity of pharmacokinetics in the therapeutic dose range.
Croatian: Linearnost/nelinearnost Ispitivanja jednokratne doze pokazuju da je farmakokinetika u terapijskom rasponu doza linearna.
English: Some medicinal products that can adversely affect renal function which may increase the risk of lactic acidosis, e.g. NSAIDS, including selective cyclo-oxygenase (COX) II inhibitors, ACE inhibitors, angiotensin II receptor antagonists and diuretics, especially loop diuretics.
Croatian: Neki lijekovi mogu štetno utjecati na funkciju bubrega, što može povećati rizik od laktacidoze, npr. NSAIL-ovi, uključujući selektivne inhibitore ciklooksigenaze (COX) II, ACE inhibitore, antagoniste receptora angiotenzina II i diuretike, osobito diuretike Henleove petlje.
English: This can lead to a risk of hypoglycaemia (low blood sugar): - gemfibrozil (to lower high cholesterol level) - angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (to treat high blood pressure) - cimetidine (to reduce stomach acid)
Croatian: To može dovesti do rizika hipoglikemije (niskog šećera u krvi): - gemfibrozil (za sniženje povišenog kolesterola) - inhibitori angiotenzin-konvertirajućeg enzima (ACE) i antagonisti receptora angiotenzina II (za liječenje visokog krvnog tlaka) - cimetidin (za smanjenje želučane kiseline)
English: not known not known liver function tests abnormal5
Croatian: nepoznato nepoznato poremećeni testovi jetrene funkcije5
English: Symptoms of lactic acidosis include: vomiting stomach ache (abdominal pain) muscle cramps a general feeling of not being well with severe tiredness difficulty in breathing reduced body temperature and heartbeat
Croatian: Simptomi laktacidoze uključuju: povraćanje bol u trbuhu (bol u abdomenu) grčevi u mišićima opće loše osjećanje uz jaki umor otežano disanje smanjena tjelesna temperatura i usporen rad srca
English: Broken bones have been reported commonly (may affect up to 1 in 10 people) in female patients taking Glubrava and have also been reported in male patients (frequency cannot be estimated from the available data) taking Glubrava.
Croatian: Prijelomi kostiju su često prijavljivani (mogu se pojaviti u do 1 na 10 osoba) u žena koje su uzimale Glubrava, a također su prijavljivani i u muškaraca (učestalost se ne može procijeniti iz dostupnih podataka) koji su uzimali Glubrava.
English: In clinical trials of up to two years duration, pioglitazone reduced total plasma triglycerides and free fatty acids, and increased HDL-cholesterol levels, compared with placebo, metformin or gliclazide.
Croatian: U kliničkim ispitivanjima u trajanju do dvije godine, pioglitazon je snizio ukupne trigliceride i slobodne masne kiseline u plazmi i povisio razine HDL-kolesterola u usporedbi s placebom, metforminom i gliklazidom.
English: Uncommon inflammation of the sinuses (sinusitis) gas difficulty sleeping (insomnia)
Croatian: Manje često - upala sinusa (sinusitis) - vjetrovi - poteškoće sa spavanjem (nesanica)
English: Since insulin and pioglitazone are both associated with fluid retention, concomitant administration of insulin and Glubrava may increase the risk of oedema.
Croatian: Budući da se i inzulin i pioglitazon povezuju sa zadržavanjem tekućine, istovremena primjena inzulina i lijeka Glubrava može povećati rizik od edema.
English: The improved glycaemic control is associated with a reduction in both fasting and postprandial plasma insulin concentrations.
Croatian: Poboljšana kontrola glikemije povezana je sa smanjenjem koncentracije inzulina u plazmi natašte i nakon obroka.
English: Blood and lymphatic system disorders anaemia common
Croatian: Poremećaji krvi i limfnog sustava anemija često
English: Liver enzymes should be checked prior to the initiation of therapy with Glubrava in all patients.
Croatian: Jetrene enzime treba provjeriti u svih bolesnika prije početka liječenja lijekom Glubrava.
English: In most clinical trials, reduced total plasma triglycerides and free fatty acids, and increased HDL-cholesterol levels were observed as compared to placebo, with small, but not clinically significant increases in LDL-cholesterol levels.
Croatian: U većini kliničkih ispitivanja opaženo je sniženje ukupnih triglicerida i slobodnih masnih kiselina u plazmi te povišenje razine HDL-kolesterola u usporedbi s placebom, uz malo, ali ne i klinički značajno povišenje razine LDL-kolesterola.
English: The other ingredients are microcrystalline cellulose, povidone (K30), croscarmellose sodium magnesium stearate, hypromellose, macrogol 8000, talc and titanium dioxide (E171).
Croatian: magnezijev stearat, hipromeloza, makrogol 8000, talk i titanijev dioksid (E171).
English: The effect of pioglitazone (45 mg monotherapy vs. placebo) was studied in a small 18-week trial in type 2 diabetics.
Croatian: Učinak pioglitazona (monoterapija dozom od 45 mg naspram placebo) proučen je u malom ispitivanju u trajanju od 18 tjedana u osoba sa šećernom bolešću tipa
English: Delpharm Novara S.r.l.
Croatian: Delpharm Novara S.r.l Via Crosa, 86
English: Steady state pharmacokinetics are similar in patients age 65 and over and young subjects.
Croatian: Farmakokinetika u stanju dinamičke ravnoteže u bolesnika u dobi od 65 ili više godina slična je onoj u mlađih osoba.
English: Your doctor will take this into account when treating your diabetes.
Croatian: Liječnik koji Vas liječi zbog šećerne bolesti uzet će to u obzir.
English: Musculoskeletal and connective tissue disorders bone fracture6
Croatian: Poremećaji mišićno-koštanog sustava i vezivnog tkiva prijelomi kostiju6
English: The observed excess risk of fractures for women in this dataset on pioglitazone is therefore 0.8 fractures per 100 patient years of use.
Croatian: Opaženo povećanje rizika od prijeloma u žena u ovom sklopu podataka o pioglitazonu stoga iznosi 0,8 prijeloma na 100 bolesnik-godina primjene.
English: Post marketing cases of peripheral oedema and cardiac failure have also been reported in patients with concomitant use of pioglitazone and nonsteroidal anti-inflammatory drugs, including selective COX-2 inhibitors.
Croatian: Nakon stavljanja lijeka u promet prijavljeni su slučajevi perifernih edema i zatajenja srca kod bolesnika koji su istodobno uzimali pioglitazon s nesteroidnim protuupalnim lijekovima, uključujući i selektivne COX-2 inhibitore.
English: In controlled clinical trials the incidence of reports of heart failure with pioglitazone treatment was the same as in placebo, metformin and sulphonylurea treatment groups, but was increased when used in combination therapy with insulin.
Croatian: U kontroliranim kliničkim ispitivanjima, zabilježena incidencija zatajenja srca u skupinama liječenima pioglitazonom bila je jednaka kao i u skupinama koje su primale placebo, metformin ili sulfonilureju, ali bilo je češće u kombiniranoj terapiji s inzulinom.
English: Lactic acidosis is characterised by acidotic dyspnoea, abdominal pain, muscle cramps, asthenia and hypothermia followed by coma.
Croatian: Značajke laktacidoze su acidozna dispneja, bol u abdomenu, grčevi u mišićima, astenija i hipotermija nakon koje slijedi koma.
English: Similar changes in body fat distribution on pioglitazone have been accompanied by an improvement in insulin sensitivity.
Croatian: Slične promjene u raspodjeli masnog tkiva u bolesnika koji su uzimali pioglitazon bile su praćene poboljšanom osjetljivošću na inzulin.
English: In clinical trials with pioglitazone there was evidence of dose related weight gain, which may be due to fat accumulation and in some cases associated with fluid retention.
Croatian: Kliničkim ispitivanjima pioglitazona dokazalo se da je povećanje tjelesne težine povezano s dozom, što može biti posljedica nakupljanja masnog tkiva, a u nekim je slučajevima povezano sa zadržavanjem tekućine.
English: The fixed dose combination tablet of pioglitazone 15 mg/metformin 850 mg BID (N=201), pioglitazone 15 mg BID (N=189), and metformin 850 mg BID (N=210) were evaluated in type 2 diabetes mellitus patients with mean baseline HbA1c of 9.5% in a randomised double-blind, parallel-group study.
Croatian: Fiksna kombinacija pioglitazona u dozi od 15 mg i metformina u dozi od 850 mg u tableti dvaput na dan (N = 201), pioglitazon u dozi od 15 mg dvaput na dan (N = 189) i metformin u dozi od 850 mg dvaput na dan (N = 210) ispitana je u randomiziranom, dvostruko slijepom ispitivanju na usporednim skupinama bolesnika sa šećernom bolešću tipa 2 i srednjom vrijednošću početnog HbA1c od 9,5%.
English: The following statements reflect the pharmacokinetic properties of the individual active substances of Glubrava.
Croatian: Sljedeće tvrdnje odnose se na farmakokinetička svojstva pojedine djelatne tvari u lijeku Glubrava.
English: There have been no formal interaction studies for Glubrava.
Croatian: Nisu provedena službena ispitivanja interakcija lijeka Glubrava.
English: Dietary acidification significantly decreased but did not abolish the incidence of tumours.
Croatian: Zakiseljavanje prehranom značajno je smanjilo incidenciju, ali nije i spriječilo nastanak tumora.
English: In PROactive, a cardiovascular outcome study, 5,238 patients with type 2 diabetes mellitus and pre-existing major macrovascular disease were randomised to pioglitazone or placebo in addition to existing antidiabetic and cardiovascular therapy, for up to 3.5 years.
Croatian: U PROactive ispitivanju kardiovaskularnog ishoda, 5238 bolesnika sa šećernom bolešću tipa 2 i velikim makrovaskulanim bolestima bilo je randomizirano u skupinu koja je primala pioglitazon i skupinu koja je primala placebo uz postojeću antidijabetičku i kardiovaskularnu terapiju, u trajanju do 3,5 godine.
English: In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained (see section 4.4).
Croatian: S obzirom na moguće rizike dugotrajnije terapije, liječnici koji propisuju lijek trebaju rutinski kontrolirati održanost koristi primjene pioglitazona (vidjeti dio 4.4).
English: In vitro studies have shown no evidence that pioglitazone inhibits any subtype of cytochrome P450.
Croatian: In vitro ispitivanja nisu dokazala da pioglitazon inhibira ijedan podtip citokroma P450.
English: In vitro studies have shown no inhibition of any subtype of cytochrome P450.
Croatian: In vitro ispitivanja pokazala su da nema inhibicije niti jedne podvrste citokroma P450.
English: Therefore, close monitoring of glycaemic control, dose adjustment within the recommended posology and changes in diabetic treatment should be considered when cationic medicinal products that are eliminated by renal tubular secretion are co-administered.
Croatian: Potrebne su pažljive kontrole glikemije te razmotriti prilagodbu doze unutar preporučenog raspona doza i promjenu liječenja šećerne bolesti kad se istodobno primjenjuju kationski lijekovi koji se eliminiraju tubularnom sekrecijom u bubrezima.
English: Takeda Pharma A/S Tlf: +45 46 77 11 11
Croatian: Danmark Takeda Pharma A/S Tlf: +45 46 77 11 11
English: Pregnancy and breast-feeding - you must tell your doctor if you are pregnant, think you may be pregnant or are planning to have a baby.
Croatian: - Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku.
English: The recommended dose of Glubrava is 30 mg/day pioglitazone plus 1,700 mg/day of metformin hydrochloride (this dose is achievable with one tablet of Glubrava 15 mg/850 mg, taken twice a day).
Croatian: Odrasli s normalnom funkcijom bubrega (GFR ≥ 90 ml/min) Preporučena doza lijeka Glubrava je 30 mg pioglitazona na dan plus 1700 mg metforminklorida na dan (ova se doza može postići jednom tabletom lijeka Glubrava 15 mg/850 mg, koja se uzima dvaput na dan).
English: No animal studies have been conducted with the combined products of Glubrava.
Croatian: Nisu provedena ispitivanja na životinjama kombinacije lijekova u lijeku Glubrava.
English: Luxe mbourg/Luxemburg Takeda Belgium Tél/Tel: +32 2 464 06 11 Takeda-belgium@takeda.com
Croatian: Luxembourg/Luxemburg Takeda Belgium Tél/Tel: +32 2 464 06 11 takeda-belgium@takeda.com
English: If a patient wishes to become pregnant, treatment with Glubrava should be discontinued.
Croatian: Ako bolesnica želi zatrudnjeti, liječenje lijekom Glubrava treba prekinuti.
English: If jaundice is observed, the medicinal product should be discontinued.
Croatian: Ako postoji žutica, primjenu lijeka treba prekinuti.
English: In a 20-week study, as well as reducing fasting triglycerides, pioglitazone reduced postprandial hypertriglyceridaemia through an effect on both absorbed and hepatically synthesised triglycerides.
Croatian: U ispitivanju u trajanju od 20 tjedana, pioglitazon je uz sniženje triglicerida natašte snizio i postprandijalnu hipertrigliceridemiju djelujući i na apsorbirane trigliceride i na one sintetizirane u jetri.
English: If you have any further questions on the use of this medicine ask your doctor or pharmacist.
Croatian: U slučaju bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se svom liječniku ili ljekarniku.
English: If you experience this symptom for the first time, talk to your doctor as soon as possible.
Croatian: Ako prvi put imate ovaj simptom, obavijestite čim prije svog liječnika.
English: 56 tablets
Croatian: 56 tableta
English: Takeda Polska Sp. z o.o.
Croatian: Takeda Italia S.p.A.
English: 9 In clinical trials with pioglitazone the incidence of elevations of ALT greater than three times the upper limit of normal was equal to placebo but less than that seen in metformin or sulphonylurea comparator groups.
Croatian: U kliničkim ispitivanjima pioglitazona, incidencija povišenja ALT-a više od tri puta iznad gornje granice normale bilo je jednako često kao uz placebo, ali manje često nego u skupinama koje su kao komparator primale metformin ili sulfonilureju.
English: Treatment with pioglitazone has been shown to reduce hepatic glucose output and to increase peripheral glucose disposal in the case of insulin resistance.
Croatian: Pokazalo se da liječenje pioglitazonom smanjuje proizvodnju glukoze u jetri i povećava raspoloživost glukoze na periferiji u slučaju inzulinske rezistencije.
English: Concomitant use not recommended Alcohol
Croatian: Istodobna primjena koja se ne preporučuje
English: When activity, concentrations and protein binding are taken into account, pioglitazone and metabolite M-III contribute equally to efficacy.
Croatian: Kad se uzmu u obzir aktivnost, koncentracije i vezanje za proteine, pioglitazon i metabolit
English: A higher rate of fractures was observed in women taking pioglitazone (2.6%) versus comparator (1.7%).
Croatian: Veća stopa prijeloma bila je primijećena u žena koje su uzimale pioglitazon (2,6%) u usporedbi s onima koje su uzimale komparator (1,7%).
English: Metformin stimulates intracellular glycogen synthesis by acting on glycogen synthase.
Croatian: Metformin potiče sintezu unutarstaničnog glikogena djelujući na glikogen sintetazu.
English: - do not use this medicine if you are breastfeeding or are planning to breast-feed (see section “Do not take Glubrava”).
Croatian: Nemojte uzimati ovaj lijek ako dojite ili planirate dojiti (vidjeti dio
English: if you have cysts on your ovaries (polycystic ovary syndrome).
Croatian: - ako imate ciste na jajnicima (sindrom policističnih jajnika).
English: The following data are findings in studies performed with pioglitazone or metformin individually.
Croatian: Sljedeći podaci su rezultati ispitivanja provedenih posebno s pioglitazonom i posebno s metforminom.
English: The observed excess risk of fractures for women on pioglitazone in this study is therefore 0.5 fractures per 100 patient years of use.
Croatian: Opaženi dodatni rizik od prijeloma u žena koje su uzimale pioglitazon u ovom ispitivanju stoga iznosi 0,5 prijeloma na 100 bolesnik-godina primjene.
English: Glubrava should be used every day to work properly.
Croatian: Kako bi Glubrava ispravno djelovala, potrebno ju je uzimati svaki dan.
English: The decision whether to continue the patient on therapy with Glubrava should be guided by clinical judgement pending laboratory evaluations.
Croatian: Odluku o nastavku liječenja lijekom Glubrava treba donijeti na temelju kliničke procjene i ovisno o laboratorijskim nalazima.
English: Heart failure has been reported with marketing use of pioglitazone and more frequently when pioglitazone was used in combination with insulin or in patients with a history of cardiac failure (see section 4.4).
Croatian: Zatajenje srca uz primjenu pioglitazona zabilježeno je nakon stavljanja lijeka u promet, i bilo je češće kad se pioglitazon primjenjivao u kombinaciji s inzulinom ili u bolesnika sa zatajenjem srca u anamnezi (vidjeti dio 4.4).
English: After an oral dose of metformin, tmax is reached in 2.5 h. Absolute bioavailability of a 500 mg metformin tablet is approximately 50-60% in healthy subjects.
Croatian: Apsolutna bioraspoloživost tablete metformina od 500 mg približno je 50-60% u zdravih ispitanika.
English: There was a small reduction in mean haemoglobin (4% relative reduction) and haematocrit (4.1% relative reduction) during therapy with pioglitazone, consistent with haemodilution.
Croatian: Tijekom terapije pioglitazonom došlo je do malog smanjenja srednje vrijednosti hemoglobina (relativno smanjenje za 4%) i hematokrita (relativno smanjenje za 4,1%), sukladno hemodiluciji.
English: Neoplasms benign, malignant and unspecified (including cysts and polyps) bladder cancer uncommon uncommon
Croatian: Dobroćudne, zloćudne i nespecificirane novotvorine (uključujući ciste i polipe) karcinom mokraćnog mjehura manje često manje često
English: Localised swelling (oedema) has also been experienced commonly (may affect up to 1 in 10 people) in patients taking Glubrava in combination with insulin.
Croatian: Lokalizirano oticanje (edemi) također je bilo često u bolesnika koji uzimaju lijek Glubrava u kombinaciji s inzulinom (može se javiti u do 1 na 10 osoba).
English: Glubrava is contraindicated during breast-feeding (see section 4.3).
Croatian: Lijek Glubrava je kontraindiciran tijekom dojenja (vidjeti dio 4.3).
English: Thu. 1
Croatian: Čet 1
English: There was no tumourigenic response in mice of either sex. Hyperplasia of the urinary bladder was not seen in dogs or monkeys treated with pioglitazone for up to 12 months.
Croatian: Hiperplazija mokraćnog mjehura nije opažena u pasa ili majmuna liječenih pioglitazonom do 12 mjeseci.
English: When clinically appropriate, direct change from metformin monotherapy to Glubrava may be considered.
Croatian: U klinički opravdanim slučajevima može se razmotriti izravna zamjena monoterapije metforminom s lijekom Glubrava.
English: Thiazolidinediones act primarily by reducing insulin resistance and biguanides act primarily by decreasing endogenous hepatic glucose production.
Croatian: Tiazolidindioni primarno djeluju tako da smanjuju inzulinsku rezistenciju, a bigvanidi tako da smanjuju endogeno stvaranje glukoze u jetri.
English: Frequency of adverse reactions Pioglitazone Metformin Glubrava
Croatian: Učestalost nuspojave Pioglitazon Metformin Glubrava
English: No increase in fracture rates was observed in men treated with pioglitazone (1.7%) versus comparator (2.1%).
Croatian: Nije opaženo povećanje stopa prijeloma u muškaraca liječenih pioglitazonom (1,7%) u usporedbi s komparatorom (2,1%).
English: 8 In active comparator controlled trials mean weight increase with pioglitazone given as monotherapy was 2-3 kg over one year.
Croatian: U ispitivanjima kontroliranima aktivnim komparatorom, srednja vrijednost povećanja tjelesne težine monoterapijom pioglitazonom iznosila je 2-3 kg tijekom jedne godine.
English: No increase in fracture rates was observed in men treated with pioglitazone (1.3%) versus comparator (1.5%).
Croatian: Nije opaženo povećanje stopa prijeloma u muškaraca liječenih pioglitazonom (1,3%) u usporedbi s komparatorom (1,5%).
English: Thu. 2
Croatian: Čet 2
English: Danmark
Croatian: Danska
English: It is recommended, therefore, that patients treated with Glubrava undergo periodic monitoring of liver enzymes.
Croatian: Stoga se u bolesnika liječenih lijekom Glubrava preporučuje povremeno kontrolirati jetrene enzime.
English: 98 tablets
Croatian: 98 tableta
English: This has been shown at therapeutic doses in controlled, medium-term or long-term clinical studies: metformin reduces total cholesterol, LDLc and triglyceride levels.
Croatian: U kontroliranim kliničkim ispitivanjima srednjeg i dugog trajanja pokazalo se da metformin pri terapijskim dozama snizuje razine ukupnog kolesterola, LDL-kolesterola i triglicerida.
English: How to take Glubrava
Croatian: Kako uzimati lijek Glubrava
English: If a pregnancy occurs, treatment with Glubrava should be discontinued.
Croatian: Ako nastupi trudnoća, liječenje lijekom Glubrava treba prekinuti.
English: What Glubrava looks like and contents of the pack The film-coated tablets (tablets) are white to off white, oblong, convex, embossed '15 / 850' on one face and ‘4833M' on the other.
Croatian: Filmom obložene tablete (tablete) su bijele do gotovo bijele boje, ovalne, konveksne, s utisnutim „15 / 850“ na jednoj strani i „4833M“ na drugoj.
English: 28 tablets
Croatian: 28 tableta
English: Bladder cancer
Croatian: Karcinom mokraćnog mjehura
English: 30 tablets
Croatian: 30 tableta
English: 90 tablets
Croatian: 90 tableta
English: Pioglitazone should be used with caution during concomitant administration of cytochrome P450 2C8 inhibitors (e.g. gemfibrozil) or inducers (e.g. rifampicin).
Croatian: Pioglitazon treba primjenjivati s oprezom tijekom istodobne primjene inhibitora (npr. gemfibrozil) ili induktora (npr. rifampicin) citokroma P450 2C8.
English: Metformin is contraindicated in patients with GFR < 30 mL/min and should be temporarily discontinued in the presence of conditions that alter renal function, see section 4.3.
Croatian: GFR je potrebno procijeniti prije početka liječenja i redovito nakon toga, vidjeti dio 4.2. Metformin je kontraindiciran u bolesnika s GFR < 30 ml/min i njegovu je primjenu potrebno privremeno prekinuti ako su prisutna stanja koja mijenjaju funkciju bubrega, vidjeti dio 4.3.