FrancophonIA/ELRC3.0 huggingface dataset:
English: - Steroide medicines (such as hydrocortisone, prednisolone and dexamethasone) or other medication which suppress the immune system.
Slovenian: - steroidna zdravila (npr. hidrokortizon, prednizolon in deksametazon), ali druga zdravila, ki zavirajo imunski sistem.
English: The CHMP was of the view that it should be mentioned that the angiotensin escape phenomenon (renin-angiotensin system activation and increased activity in sympathetic system) can occur (and was observed) in patients treated with ACE inhibitors as monotherapy (Roig e, et al Eur.
Slovenian: CHMP je menil, da je treba navesti, da lahko pride do pojava zmanjšanja ravni angiotenzina (aktivacije sistema renin-angiotenzin in povečane aktivnosti simpatičnega sistema; pojav je tudi bil opažen) pri bolnikih, ki so prejemali zaviralce ACE kot monoterapijo (Roig E., et al Eur.
English: However it is also very well known that ACE inhibitors may have serious impact on the renal function, especially in the case of reduced renal perfusion.
Slovenian: Zelo znano je tudi, da utegnejo imeti zaviralci ACE resen učinek na delovanje ledvic, zlasti v primeru zmanjšane perfuzije ledvic.
English: Regarding pregnancy, the MAH agreed to comply with the wording agreed by the CHMP Pharmacovigilance Working Party (PhVWP) recommendation for this section.
Slovenian: Kar zadeva nosečnost, se je imetnik dovoljenja za promet z zdravilom strinjal, da bo upošteval besedilo, ki ga je priporočila delovna skupina za farmakovigilanco odbora CHMP za to poglavje.
English: Pharmacotherapeutic group: ACE inhibitor, ATC code: C09AA08
Slovenian: Farmakoterapevtska skupina: zaviralci angiotenzinske konvertaze; oznaka ATC: C09AA08
English: Hypertensive patients receiving diuretics: If possible, the diuretic should be discontinued 2 - 3 days before beginning therapy with Vascace to reduce the likelihood of symptomatic hypotension.
Slovenian: Hipertenzivni bolniki, ki prejemajo diuretike: Če je mogoče, je treba uporabo diuretika prekiniti 2 ali 3 dni pred začetkom zdravljenja z zdravilom Vascace, da bi zmanjšali verjetnost simptomatske hipotenzije.
English: - Medicines called ‘non-steroidal anti-inflammatory drugs' (NSAIDs).
Slovenian: - zdravila, imenovana "nesteroidna protivnetna zdravila".
English: Most ACE inhibitors (e.g. captopril, cilazapril, enalapril, ramipril, perindopril, trandolapril, benazepril) were shown to have beneficial action on hard and intermediete outcomes in patients with chronic heart failure.
Slovenian: Večina zaviralcev ACE (npr. kaptopril, cilazapril, enalapril, ramipril, perindopril, trandolapril, benazepril) imajo dokazano koristne učinke na izmerljive in vmesne izide pri bolnikih s kroničnim srčnim popuščanjem.
English: Similar caution should be taken for patients with angina pectoris or cerebrovascular disease, in whom hypotension can cause myocardial or cerebral ischaemia.
Slovenian: Podobna previdnost je potrebna pri bolnikih z angino pektoris ali cerebrovaskularno boleznijo, ki jim lahko hipotenzija povzroči ishemijo miokarda ali možganov.
English: - Vascace may be taken before or after a meal.
Slovenian: - Zdravilo Vascace lahko vzamete pred obrokom ali po njem.
English: - if you undergo LDL apheresis with dextrane sulphate.
Slovenian: - če se pripravljate na aferezo LDL z dekstranovim sulfatom.
English: Although ACE inhibitors decrease blood pressure in all forms of hypertension, the efficacy is different as they are less effective in patients with low-renin hypertension.
Slovenian: Čeprav zaviralci ACE zmanjšujejo krvni tlak pri vseh oblikah hipertenzije, je učinkovitost različna, saj so manj učinkoviti pri bolnikih s hipertenzijo z nizko koncentracijo renina.
English: The signs include swelling of the face, lips, mouth or tongue.
Slovenian: Med njegovimi znaki so otekanje obraza, ustnic, ust ali jezika.
English: For patients with impaired renal function, the dosing recommendations were based on data from a number of Roche studies and published clinical trials.
Slovenian: Pri bolnikih z okvarjenim delovanjem ledvic so priporočila glede odmerjanja temeljila na podatkih iz številnih študij in objavljenih kliničnih preskušanj družbe Roche.
English: Vascace is not recommended in early pregnancy and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see the sections on ‘Pregnancy' and ‘Breastfeeding').
Slovenian: Uporaba zdravila Vascace v zgodnji nosečnosti ni priporočljiva, ne smete pa ga jemati, če ste noseči dlje kot 3 mesece, ker lahko v tej fazi nosečnosti resno škoduje otroku (glejte poglavji "Nosečnost" in "Dojenje").
English: Hypotension contributes further to a reduction in renal perfusion (see section 4.4 `Hypotension').
Slovenian: Hipotenzija dodatno pripomore k zmanjšanju ledvične perfuzije (glejte poglavje 4.4, "Hipotenzija").
English: Adverse reactions that were not observed during cilazapril clinical trials but have been reported in association with other ACE inhibitors or derived from postmarketing case reports are classified as `rare'.
Slovenian: Neželeni učinki, ki jih niso ugotovili v kliničnih preskušanjih s cilazaprilom, ampak so bili opisani v povezavi z drugimi zaviralci ACE ali evidentirani na podlagi poročil o primerih v obdobju trženja, so opredeljeni kot "redki".
English: The following effects may happen: feeling dizzy or light-headed, shallow breathing, cold clammy skin, being unable to move or speak and a slow heart beat.
Slovenian: Pojavijo se lahko naslednji učinki: omotica ali vrtoglavica, plitvo dihanje, hladna, lepljiva koža, nezmožnost gibanja ali govorjenja in počasno bitje srca.
English: If you take more Vascace than you should
Slovenian: Če ste vzeli večji odmerek zdravila Vascace, kot bi smeli
English: ACE inhibitors can cause hyperkalemia because they inhibit the release of aldosterone.
Slovenian: Zaviralci ACE lahko povzročijo hiperkaliemijo, ker zavirajo sproščanje aldosterona.
English: In hypertensive patients with moderate to severe renal impairment, the glomerular filtration rate and renal blood flow generally remained unchanged with Vascace, despite a clinically significant blood pressure reduction.
Slovenian: Pri hipertenzivnih bolnikih z zmerno do hudo okvaro ledvic se hitrost glomerularne filtracije in ledvični pretok krvi med uporabo zdravila Vascace na splošno ne spremenita, kljub klinično pomembnemu znižanju krvnega tlaka.
English: ACE inhibitors may cause severe hypotension, especially when starting treatment.
Slovenian: Zaviralci ACE lahko povzročijo hudo hipotenzijo, zlasti na začetku zdravljenja.
English: Specific dosing recommendation for renovascular hypertension has been covered by the dosing instructions for patients with impaired renal function in this section 4.2.
Slovenian: Specifična priporočila glede odmerjanja pri renovaskularni hipertenziji so vključena v navodila za odmerjanje pri bolnikih z okvarjenim delovanjem ledvic v tem poglavju 4.2.
English: - If you are already taking a diuretic (‘water tablets'), your doctor may tell you to stop taking it about 3 days before you start taking Vascace.
Slovenian: - Če že jemljete diuretik ("tablete za odvajanje vode"), vam bo zdravnik morda naročil, da diuretik nehate jemati približno 3 dni prej, preden začnete jemati zdravilo Vascace.
English: Table 1: Recommended dosage schedule for patients with renal impairment Creatinine clearance
Slovenian: Tabela 1: Priporočena shema odmerjanja pri bolnikih z okvaro ledvic Očistek kreatinina
English: - if you have had a stroke or have problems with the blood supply to your brain.
Slovenian: - če ste kdaj imeli možgansko kap ali imate težave s prekrvitvijo možganov.
English: Cilazapril belongs to the family of angiotensin converting enzyme (ACE) inhibitors.
Slovenian: Cilazapril spada v družino zaviralcev angiotenzinske konvertaze (zaviralcev ACE).
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORMS, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTES OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
Slovenian: DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
English: Rare
Slovenian: redki
English: Blood problems reported with ACE inhibitors include: - Low numbers of red blood cells (anaemia).
Slovenian: Med spremembami krvi, ki so jih opisali med uporabo zaviralcev ACE, so: - zmanjšanje števila rdečih krvnih celic (anemija).
English: ACE inhibitors should not be initiated during pregnancy.
Slovenian: Zdravljenja z zaviralci ACE se ne sme uvesti med nosečnostjo.
English: This can be avoided by temporarily withholding ACE inhibitor therapy prior to each apheresis.
Slovenian: To je mogoče preprečiti z začasno prekinitvijo uporabe zaviralca ACE pred vsako aferezo.
English: Headache is a commonly reported adverse event, although the incidence of headache is greater in patients receiving placebo than in those receiving ACE inhibitors.
Slovenian: Glavobol je neželeni dogodek, o katerem so poročali pogosto, čeprav je incidenca glavobola višja pri bolnikih, ki prejemajo placebo, kot pri tistih, ki prejemajo zaviralce ACE.
English: Angioedema has been associated with ACE inhibitors, with a reported incidence of 0.1-0.5%.
Slovenian: Poročali so o povezanosti zaviralcev ACE z angioedemom, in sicer z incidenco od 0,1 do 0,5 %.
English: Since treatment with diuretics may be a contributory factor, they should be discontinued and renal function should be monitored during the first weeks of Vascace therapy.
Slovenian: Ker ima zdravljenje z diuretiki lahko pomembno vlogo, je treba prenehati njihovo jemanje in spremljati delovanje ledvic v prvih tednih zdravljenja z zdravilom Vascase.
English: Treatment of hypertension
Slovenian: Zdravljenje hipertenzije
English: Ingestion of food immediately prior to Vascace administration delays and reduces absorption to a minor extent which, however, is therapeutically irrelevant.
Slovenian: Zaužitje hrane tik pred zdravilom Vascace upočasni in zmanjša absorpcijo le v majhni meri; to zmanjšanje je terapevtsko nepomembno.
English: Do not take Vascace if any of the above apply to you.
Slovenian: Ne vzemite zdravila Vascace, če kaj od naštetega velja za vas.
English: This may make you feel weak, dizzy or light-headed, and may lead to blurred vision and fainting.
Slovenian: Zaradi tega se lahko počutite šibki, omotični ali vrtoglavi; pojavita se lahko tudi zamegljen vid in vrtoglavica.
English: Hence, blockade of angiotensin II formation, and possibly also an increase in the formation of bradykinin, causes efferent arteriolar vasodilation resulting in a reduction in glomerular filtration pressure.
Slovenian: Zaradi tega lahko blokada nastajanja angiotenzina II in morda tudi večje nastajanje bradikinina povzročita vazodilatacijo eferentnih arteriol s posledičnim zmanjšanjem tlaka glomerularne filtracije.
English: Section 4.7 - Effects on ability to drive and use machines Taking into account the recommendation of the CHMP and those provided in the SPC guideline concerning Section 4.7, the wording proposed by the MAH was agreed.
Slovenian: Poglavje 4.7 - Vpliv na sposobnost vožnje in upravljanja s stroji Ob upoštevanju priporočila CHMP in priporočil iz smernic za povzetke glavnih značilnosti zdravila v zvezi s poglavjem 4.7 je bilo sprejeto besedilo, ki ga je predlagal imetnik dovoljenja za promet z zdravilom.
English: No data on overall survival, cardiovascular morbidity, frequency of CV hospitalisation of patients treated with cilazapril for CHF have been presented.
Slovenian: Ni predloženih podatkov o celokupnem preživetju, kardiovaskularni obolevnosti in pogostosti kardiovaskularnih hospitalizacij bolnikov, ki so prejemali cilazapril za zdravljenje kroničnega srčnega popuščanja.
English: The signs include increased number of infections, for example in your mouth, gums, throat and lungs.
Slovenian: Med znaki so številnejše okužbe, npr. v ustih, na dlesnih, v žrelu in v pljučih.
English: The harmonised list of undesirable effects was derived from clinical trials and post-marketing data in association with cilazapril and/or other ACE inhibitors.
Slovenian: Usklajen seznam neželenih učinkov izvira iz kliničnih preskušanj in postmarketinških podatkov v povezavi s cilazaprilom in/ali drugimi zaviralci ACE.
English: - the scope of the referral was the harmonisation of the Summary of Products Characteristics, labelling and package leaflet.
Slovenian: - obseg napotitvenega postopka je bil uskladitev povzetka glavnih značilnosti zdravila, označevanja in navodila za uporabo.
English: The dosing schedule of once daily, administered before or after a meal as proposed by the MAH was considered to be approvable by the CHMP.
Slovenian: CHMP je menil, da je shemo odmerjanja enkrat dnevno pred obrokom ali po njem, kakor je predlagal imetnik dovoljenja za promet z zdravilom, mogoče odobriti.
English: If you have a severe reaction called angioedema, stop taking Vascace and see a doctor straight away.
Slovenian: Če se vam pojavi hud neželeni učinek, ki ga imenujemo angioedem, nehajte jemati zdravilo Vascace in nemudoma poiščite zdravniško pomoč.
English: The hypotensive effects can be reduced by discontinuation of the diuretic, by increasing volume or salt intake or by initiating therapy with a low dose of cilazapril.
Slovenian: Hipotenzivne učinke je mogoče zmanjšati s prenehanjem uporabe diuretika, povečanjem volumna ali uživanjem soli, ali z uvedbo zdravljenja s cilazaprilom z majhnim odmerkom.
English: Hereditary or idiopathic angioedema
Slovenian: Prirojeni ali idiopatični angioedem.
English: The results of an open label non-comparative dose-adjustment study in the elderly with uncomplicated essential hypertension were discussed by the MAH, to substantiate the dosing regimen for the elderly patients with hypertension.
Slovenian: Imetnik dovoljenja za promet z zdravilom je razpravljal o rezultatih odprte, neprimerjalne študije prilagoditve odmerka pri starejših osebah z nezapleteno esencialno hipertenzijo, da bi utemeljil režim odmerjanja pri starejših bolnikih s hipertenzijo.
English: In patients with renal artery stenosis, activation of the renin-angiotensin-aldosterone system helps to maintain renal perfusion by causing constriction of the efferent arteriole.
Slovenian: Pri bolnikih s stenozo ledvične arterije lahko aktivacija sistema renin-angiotenzin-aldosteron pomaga vzdrževati perfuzijo ledvic s konstrikcijo eferentne arteriole.
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however, a small increase in risk cannot be excluded.
Slovenian: Epidemiološki dokazi glede tveganja teratogenosti po izpostavljenosti zaviralcem ACE v prvem tromesečju nosečnosti niso dokončni, vendar majhnega povečanja tveganja ni mogoče izključiti.
English: ACE inhibitors should be used with caution in patients with obstructive cardiac disorders (e.g. mitral stenosis, aortic stenosis, hypertrophic cardiomyopathy), since cardiac output cannot increase to compensate for systemic vasodilation, and there is a risk of severe hypotension.
Slovenian: Zaviralce ACE je treba previdno uporabljati pri bolnikih z obstruktivnimi boleznimi srca (npr. z mitralno stenozo, aortno stenozo, hipertrofično kardiomiopatijo), ker se jim minutni volumen srca ne more povečati, da bi kompenziral sistemsko vazodilatacijo, in zato obstaja tveganje hude hipotenzije.
English: As food intake has no clinically significant influence on absorption, Vascace can be administered before or after a meal.
Slovenian: Hrana nima klinično pomembnega vpliva na absorpcijo, zato je mogoče zdravilo Vascace vzeti pred jedjo ali po jedi.
English: Unless continued ACE inhibitor therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Slovenian: Če nadaljevanje zdravljenja z zaviralcem ACE ni življenjskega pomena, morajo bolnice, ki načrtujejo zanositev, začeti jemati alternativna zdravila proti hipertenziji, ki imajo potrjen varnostni profil za uporabo med nosečnostjo.
English: The signs may include: - Sudden swelling of the face, throat, lips or mouth.
Slovenian: Med znaki so lahko: - nenadno otekanje obraza, žrela, ustnic ali ust.
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded.
Slovenian: Epidemiološki podatki glede tveganja za teratogenost po izpostavljenosti zaviralcem ACE v prvem tromesečju nosečnosti niso dokončni; vendar pa majhnega povečanja tveganja ni mogoče izključiti.
English: Where the patient can tolerate the cough, it may be reasonable to continue treatment.
Slovenian: Če bolnik kašelj prenaša, je zdravljenje smiselno nadaljevati.
English: In these patients, treatment should be started under close medical supervision with low doses and careful dose titration.
Slovenian: Pri teh bolnikih je treba zdravljenje začeti pod skrbnim zdravniškim nadzorom z nizkimi odmerki in previdno titracijo odmerkov.
English: Based on the information available, and taking into account the recommendation of the CHMP, the following statement was agreed by the MAH for the section under the subheading ‘Chronic heart failure':
Slovenian: Na podlagi razpoložljivih informacij in ob upoštevanju priporočila CHMP je imetnik dovoljenja za promet z zdravilom podal naslednje besedilo za poglavje pod podnaslovom „Kronično srčno popuščanje“:
English: Renal impairment and acute renal failure are more likely in patients with severe heart failure, renal artery stenosis, pre-existing renal disorders or volume depletion (see section 4.4).
Slovenian: Okvara ledvic in akutna odpoved ledvic sta verjetnejši pri bolnikih s hudim srčnim popuščanjem, stenozo ledvične arterije, že prej obstoječimi boleznimi ledvic ali hipovolemijo (glejte poglavje 4.4).
English: Vascace induces a reduction of both supine and standing systolic and diastolic blood pressure, usually with no orthostatic component.
Slovenian: Zdravilo Vascace zniža sistolični in diastolični krvni tlak leže in stoje, ponavadi brez ortostatskega učinka.
English: Periodic monitoring of leukocyte count is recommended in such patients.
Slovenian: Takšnim bolnikom je priporočljivo redno kontrolirati število levkocitov.
English: Preventive measures include withdrawing or temporarily withholding diuretics, beginning therapy with very small doses of ACE inhibitors, and cautious dose titration.
Slovenian: Med preventivnimi ukrepi so ukinitev ali prehodno prenehanje uporabe diuretikov, uvedba zdravljenja z zelo majhnimi odmerki zaviralcev ACE in zelo pazljivo prilagajanje odmerka.
English: As recommended by the CHMP, the MAH has added an additional warning concerning the use of cilazapril in patients with high grade renal artery stenosis with renal impairment to the subsection entitled `Renal impairment' in section 4.4.
Slovenian: V skladu s priporočilom CHMP je imetnik dovoljenja za promet z zdravilom dodal dodatno opozorilo v zvezi z uporabo cilazaprila pri bolnikih s hudo stenozo renalne arterije z okvaro ledvic v podpoglavje „Okvara ledvic“ poglavja 4.4.
English: Consideration should be given to using a different type of dialysis membrane or different class of antihypertensive agent in such patients.
Slovenian: Pri takšnih bolnikih pride v poštev uporaba drugačne vrste dializne membrane ali druge skupine antihipertenzivov.
English: Section 4.3 - Contra-indications
Slovenian: Poglavje 4.3 - Kontraindikacije
English: The MAH's response refers to the results achieved by other ACE inhibitors stating the beneficial therapeutic effect for patients with chronic heart failure.
Slovenian: Odgovor imetnika dovoljenja za promet z zdravilom se nanaša na rezultate, dosežene z drugimi zaviralci ACE, ki dokazujejo koristne terapevtske učinke pri bolnikih s kroničnim srčnim popuščanjem.
English: Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter.
Slovenian: Bolniki morajo uživati zadosti vode in treba je razmisliti o nadzorovanju delovanja jeter po uvedbi sočasnega zdravljenja ter občasno med zdravljenjem.
English: What Vascace is and what it is used for Before you take Vascace How to take Vascace Possible side effects How to store Vascace Further information
Slovenian: Kaj je zdravilo Vascace in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Vascace Kako jemati zdravilo Vascace Možni neželeni učinki
English: At recommended doses, the effect of Vascace in hypertensive patients and in patients with chronic heart failure is maintained for up to 24 hours.
Slovenian: Med uporabo zdravila Vascace v priporočenih odmerkih se njegovi učinki pri hipertenzivnih bolnikih in bolnikih s kroničnim srčnim popuščanjem ohranijo do 24 ur.
English: “Limited data are available for overdosage in humans.
Slovenian: „Kar zadeva preveliko odmerjanje pri ljudeh, so na voljo omejeni podatki.
English: Because no information is available regarding the safety of cilazapril during breastfeeding, cilazapril is not recommended, and alternative treatments with better established safety profiles during breastfeeding are preferable, especially while nursing a newborn or preterm infant.”
Slovenian: Ker ni podatkov o varnosti cilazaprila med dojenjem, cilazapril ni priporočljiv; zaželeno je alternativno zdravljenje z bolj uveljavljenimi varnostnimi profili med dojenjem, še posebno med dojenjem novorojenca ali nedonošenca.“
English: The signs include feeling tired, pale skin, fast or uneven heart beat (palpitations), and feeling short of breath.
Slovenian: Med znaki so utrujenost, bleda koža, hitro ali neenakomerno bitje srca (palpitacije) in kratka sapa.
English: Hypotension and postural hypotension may occur when starting treatment or increasing dose, especially in at-risk patients (see section 4.4).
Slovenian: Hipotenzija in posturalna hipotenzija se lahko pojavita na začetku zdravljenja ali po povečanju odmerka, zlasti pri bolnikih s tveganjem (glejte poglavje 4.4).
English: If renal failure occurs, treatment should be discontinued.
Slovenian: Če pride do odpovedi ledvic, je treba zdravljenje prekiniti.
English: If you have an intolerance to lactose, talk to your doctor before taking this medicine.
Slovenian: Če ne prenašate laktoze, se posvetujte z zdravnikom, preden vzamete to zdravilo.
English: Haemodialysis: Anaphylaxis has occurred in patients dialysed with high flux membranes (e.g. AN 69) receiving ACE inhibitors.
Slovenian: Hemodializa: Anafilaksa se je pojavila pri bolnikih, dializiranih z visokopretočnimi membranami (npr. AN 69), ki so dobivali zaviralce ACE.
English: Hypotension should be treated by placing the patient supine and volume expansion.
Slovenian: Hipotenzijo je treba zdraviti tako, da se bolnika poleže in se poskrbi za ekspanzijo volumna.
English: Accordingly these results can be extrapolated also for cilazapril, where the beneficial effects of ACE inhibitors in CHF can be considered as a class effect.
Slovenian: Te rezultate je mogoče ustrezno ekstrapolirati tudi za cilazapril, kjer je koristne učinke zaviralcev ACE pri kroničnem srčnem popuščanju mogoče šteti za učinke razreda.
English: Section 4.9 - Overdose Taking into account the recommendation of the CHMP, the following proposed wording was agreed:
Slovenian: Poglavje 4.9 - Preveliko odmerjanje Ob upoštevanju priporočila CHMP je bilo sprejeto naslednje predlagano besedilo:
English: At the request of the CHMP, interactions with other medicinal products (diuretics, tricyclic antidepressants, renal effects in non-steroidal anti-inflammatory drugs, sympathomimetics, anti-diabetics and gold) were also included in the harmonized SPC, in line with the other representatives of the drug class.
Slovenian: Na zahtevo CHMP so bile v usklajeni povzetek glavnih značilnosti zdravila vključene tudi interakcije z drugimi zdravili (diuretiki, triciklični antidepresivi, učinki na ledvice pri nesteroidnih protivnetnih zdravilih, simpatomimetiki, antidiabetiki in zlato) skupaj z drugimi predstavniki razreda zdravila.