FrancophonIA/ELRC3.0 huggingface dataset:
English: Conversely, during hypoglycaemia liraglutide diminishes insulin secretion and does not impair glucagon secretion.
Slovenian: Nasprotno pa liraglutid med hipoglikemijo zmanjša izločanje insulina, ne vpliva pa na izločanje glukagona.
English: • The pen scale shows you approximately how much solution is left in your pen.
Slovenian: • Merilo preostanka prikazuje koliko je približno še ostalo raztopine v injekcijskem peresniku.
English: Dosing time
Slovenian: Čas odmerjanja
English: This is because improvement in your blood sugar may not happen straight away.
Slovenian: Meritev boste morda morali ponoviti večkrat, saj se koncentracija krvnega sladkorja morda ne bo takoj zvečala.
English: Figure 3 Mean HbA1c (%) by treatment week in patients with type 2 diabetes mellitus inadequately controlled on GLP-1 receptor agonists
Slovenian: Slika 3: Povprečna vrednost HbA1c (%) po tednih zdravljenja pri bolnikih z nezadostno urejeno sladkorno boleznijo tipa 2 pri zdravljenju z agonisti receptorjev GLP-1
English: The percentage of patients experiencing severe or blood-glucose confirmed symptomatic hypoglycaemia was 19.8% in the Xultophy group and 52.6% in the basal-bolus insulin group, and the estimated rate ratio was 0.11 [95% CI: 0.08-0.17].
Slovenian: je bil 19,8 % v skupini z zdravilom Xultophy in 52,6 % v skupini z bazalno-bolusnima insulinoma; ocenjeno razmerje pojavnosti je bilo 0,11 [95 % IZ: 0,08-0,17].
English: Liraglutide is metabolised in a similar manner to large proteins without a specific organ having been identified as major route of elimination.
Slovenian: Liraglutid se presnavlja na podoben način kot velike beljakovine.
English: Therapy with basal insulin should be discontinued prior to initiation of Xultophy.
Slovenian: Pred uvedbo zdravljenja z zdravilom Xultophy je treba zdravljenje z bazalnim insulinom ukiniti.
English: Each unused pre-filled pen (3 mL) contains 300 units of insulin degludec and 10.8 mg liraglutide.
Slovenian: En nov napolnjen injekcijski peresnik (3 ml) vsebuje 300 enot insulina degludek in 10,8 mg liraglutida.
English: Due to the liraglutide component, Xultophy is not recommended for use in patients with severe hepatic impairment (see section 5.2).
Slovenian: Zaradi sestavine liraglutid uporaba zdravila Xultophy ni priporočljiva pri bolnikih s hudo okvaro jeter
English: In three trials with patients inadequately controlled on basal insulin, systolic blood pressure was reduced by 5.4 mmHg with Xultophy and 1.7 mmHg with insulin degludec, with a statistically significant estimated treatment difference of -3.71 mmHg (p=0.0028), reduced by 3.7 mmHg with Xultophy vs 0.2 mmHg with insulin glargine, with a statistically significant estimated treatment difference of -3.57 mmHg (p<0.001) and reduced by 4.5 mmHg with Xultophy vs 1.16 mmHg with insulin glargine U100 plus insulin aspart, with a statistically significant estimated treatment difference of -3.70 mmHg (p=0.0003).
Slovenian: V treh preskušanjih, izvedenih pri bolnikih z nezadostno urejeno glikemijo pri zdravljenju z bazalnim insulinom, se je v enem preskušanju vrednost sistoličnega krvnega tlaka pri uporabi zdravila Xultophy zmanjšala za 5,4 mmHg, pri uporabi insulina degludek pa za 1,7 mmHg, s statistično značilno ocenjeno razliko zdravljenja -3,71 mmHg (p=0,0028).
English: Glucose monitoring is to be intensified and the dose adjusted on an individual basis.
Slovenian: Koncentracijo glukoze v krvi je treba spremljati pozorneje ter odmerek prilagoditi potrebam posameznega bolnika.
English: Gender had no clinically relevant effect on the pharmacokinetics of Xultophy based on results from a population pharmacokinetic analysis.
Slovenian: Rezultati analize populacijske farmakokinetike kažejo, da spol nima klinično pomembnega vpliva na farmakokinetiko zdravila Xultophy.
English: The key results of the trial are listed in Figure 5 and Table 5.
Slovenian: Ključni rezultati preskušanja so prikazani na sliki 5 in v preglednici 5.
English: Approx. how much solution is left
Slovenian: približna količina preostale raztopine
English: Non-clinical safety data revealed no safety concern for humans based on repeated dose toxicity studies.
Slovenian: Neklinični podatki na osnovi študij toksičnosti pri ponavljajočih se odmerkih ne kažejo posebnega tveganja za človeka.
English: One pre-filled pen contains 300 units insulin degludec and 10.8 mg liraglutide in 3 mL solution 1 mL solution contains 100 units of insulin degludec and 3.6 mg liraglutide One dose step contains 1 unit of insulin degludec and 0.036 mg of liraglutide
Slovenian: En ml raztopine vsebuje 100 enot insulina degludek in 3,6 mg liraglutida, En odmerni korak vsebuje 1 enoto insulina degludek in 0,036 mg liraglutida.
English: Xultophy is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus to improve glycaemic control as an adjunct to diet and exercise in addition to other oral medicinal products for the treatment of diabetes.
Slovenian: Zdravilo Xultophy je namenjeno zdravljenju odraslih z neustrezno nadzorovano sladkorno boleznijo tipa 2, in sicer za izboljšanje urejenosti glikemije.
English: Treatment with Xultophy compared to a basal-bolus insulin regimen consisting of basal insulin (insulin glargine 100 units/mL) in combination with bolus insulin (insulin aspart) studied in a 26-week trial in patients with type 2 diabetes mellitus inadequately controlled on insulin glargine and metformin demonstrated a similar reduction of HbA1c in the two groups (mean value from 8.2% to 6.7% in both groups).
Slovenian: Zdravljenje z zdravilom Xultophy v primerjavi z bazalno-bolusnim insulinskim režimom, ki je vključeval bazalni insulin (insulin glargin 100 enot/ml) v kombinaciji z bolusnim insulinom (insulin aspart), so preučevali v 26-tedenskem preskušanju pri bolnikih z neustrezno nadzorovano sladkorno boleznijo tipa 2 ob zdravljenju z insulinom glargin in metforminom.
English: 1 mL solution contains 100 units insulin degludec* and 3.6 mg liraglutide*.
Slovenian: En ml raztopine vsebuje 100 enot insulina degludek* in 3,6 mg liraglutida*.
English: • Change the place within the area where you inject each day to reduce the risk of developing lumps and skin pitting (see section 4).
Slovenian: Tako boste zmanjšali tveganje za nastanek zatrdlin ali ugreznjenosti kože (glejte poglavje 4).
English: Transfer from GLP-1 receptor agonist Xultophy
Slovenian: Prehod z zdravljenja z agonistom receptorjev GLP-1 zdravilo Xultophy agonist receptorjev GLP-1
English: Signs and symptoms of dehydration, including renal impairment and acute renal failure have been reported in clinical trials with GLP-1 receptor agonists including liraglutide, a component of Xultophy.
Slovenian: V kliničnih preskušanjih agonistov receptorjev GLP-1, vključno z liraglutidom, ki je sestavina zdravila Xultophy, so poročali o pojavu znakov in simptomov dehidracije, vključno z okvaro ledvic in akutno odpovedjo ledvic.
English: If you split the dose wrongly, you will inject too little or too much medicine.
Slovenian: Če je razdeljeni odmerek napačen, lahko injicirate preveč ali premalo zdravila, posledično pa se lahko koncentracija krvnega sladkorja zveča ali zmanjša.
English: Pancreatitis (including necrotising pancreatitis )
Slovenian: napihnjenost trebuha občasni eruktacija, flatulenca neznana pankreatitis (vključno z nekrotizirajočim pankreatitisom)
English: Each mL of solution contains 100 units of insulin degludec and 3.6 mg liraglutide.
Slovenian: En ml raztopine vsebuje 100 enot insulina degludek in 3,6 mg liraglutida.
English: Keep the cap on the pre-filled pen in order to protect from light.
Slovenian: Napolnjen injekcijski peresnik shranjujte pokrit s pokrovčkom za zagotovitev zaščite pred svetlobo.
English: This is normal, but you must still check the flow.
Slovenian: Na konici igle se lahko pojavi kapljica raztopine, kar je normalno, vendar pa morate kljub temu še preveriti pretok.
English: The rate per patient year of exposure (percentage of patients) of severe hypoglycaemia was 0.01 (1 patient out of 199) for Xultophy and 0.00 (0 patients out of 199) for insulin degludec.
Slovenian: Delež hude hipoglikemije na bolnikov-let izpostavljenosti (odstotek bolnikov) je bil pri zdravilu Xultophy 0,01 (1 od 199 bolnikov), pri insulinu degludek pa 0,00 (0 od 199 bolnikov).
English: In the LEADER trial, no long-term clinical impact of increased heart rate on the risk of cardiovascular events was observed with liraglutide (a component of Xultophy) (see section 5.1).
Slovenian: V preskušanju LEADER z liraglutidom (sestavino zdravila Xultophy) ni bilo opaženega dolgoročnega kliničnega vpliva zvišane frekvence srčnega utripa na tveganje za srčno-žilne dogodke.
English: Glucose must be given intravenously if the patient does not respond to glucagon within 10 to 15 minutes.
Slovenian: Če se bolnik na aplikacijo glukagona ne odzove v 10
English: Insulin degludec and liraglutide exposure increased proportionally with the Xultophy dose within the full dose range based on a population pharmacokinetic analysis.
Slovenian: Analiza populacijske farmakokinetike kaže, da se izpostavljenost insulinu degludek in liraglutidu povečuje sorazmerno z odmerkom zdravila Xultophy v celotnem obsegu odmerkov.
English: Transfer of patients from insulin glargine (100 units/mL) to Xultophy or intensification of insulin glargine in patients inadequately controlled on insulin glargine (20-50 units) and metformin were studied in a 26 week trial.
Slovenian: V 26-tedenskem preskušanju so preučevali prehod na zdravilo Xultophy z zdravljenja z insulinom glargin (100 enot/ml) ali intenziviranje zdravljenja z insulinom glargin pri bolnikih, ki niso bili zadostno urejeni z zdravljenjem z insulinom glargin (20-50 enot) in metforminom.
English: Thus, when blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited.
Slovenian: Ko je koncentracija glukoze v krvi velika, se izločanje insulina poveča, izločanje glukagona pa zavre.
English: • One dose step contains 1 unit of insulin degludec and 0.036 mg of liraglutide.
Slovenian: • En odmerni korak vsebuje 1 enoto insulina degludek in 0,036 mg liraglutida.
English: Instructions on how to use Xultophy 100 units/mL + 3.6 mg/mL solution for injection
Slovenian: Navodila za uporabo zdravila Xultophy 100 enot/ml + 3,6 mg/ml raztopina za injiciranje
English: • dehydration (loss of fluids from the body) can happen if you are feeling or being sick (nausea or vomiting) or have diarrhoea - it is important to drink plenty of fluids to stop dehydration.
Slovenian: • V primeru siljenja na bruhanje, bruhanja ali driske lahko pride do dehidracije (izgube tekočine iz telesa).
English: • Xultophy is administered as ‘dose steps'.
Slovenian: • Zdravilo Xultophy se odmerja v “odmernih korakih”.
English: Low blood sugar may happen if you:
Slovenian: Prenizek krvni sladkor se lahko pojavi, če:
English: Dispose of the needle safely after each use.
Slovenian: Injekcijsko iglo po vsakem injiciranju varno zavrzite.
English: DEVOTE was a randomised, double-blind, and event-driven clinical trial with a median duration of 2 years comparing the cardiovascular safety of insulin degludec versus insulin glargine (100 units/mL) in 7,637 patients with type 2 diabetes mellitus at high risk of cardiovascular events.
Slovenian: DEVOTE je bilo randomizirano, dvojno slepo in s številom dogodkov omejeno klinično preskušanje z medianim trajanjem 2 leti, v katerem so primerjali insulin degludek in insulin glargin (100 enot/ml)
English: Age had no clinically relevant effect on the pharmacokinetics of Xultophy based on results from a population pharmacokinetic analysis including adult patients up to 83 years treated with Xultophy.
Slovenian: Podatki analize populacijske farmakokinetike, vključno z bolniki, starimi do 83 let, kažejo, da starost nima klinično pomembnega vpliva na farmakokinetiko zdravila Xultophy.
English: Liraglutide exposure was decreased by 13-23% in patients with mild to moderate hepatic impairment compared to healthy subjects.
Slovenian: Pri bolnikih z blago do zmerno okvaro jeter je bila izpostavljenost liraglutidu za 13-23 % manjša kot pri zdravih osebah, pri bolnikih s hudo okvaro jeter (ocena po Child Pughu > 9) pa je bila izpostavljenost pomembno manjša (44 %).
English: Transfer from GLP-1 receptor agonist
Slovenian: Prehod z zdravljenja z agonistom receptorjev GLP-1
English: In addition, constipation, dyspepsia, gastritis, abdominal pain, gastroesophageal reflux disease, abdominal distension, eructation, flatulence and decreased appetite have been reported in up to 3.6% of patients treated with Xultophy.
Slovenian: 3,6 % bolnikov, ki so se zdravili z zdravilom Xultophy, poročali še o zaprtosti, dispepsiji, gastritisu, bolečini v trebuhu, gastroezofagealni refluksni bolezni, napihnjenosti trebuha, eruktaciji, flatulenci in zmanjšanju apetita.
English: Few cases of anaphylactic reactions with additional symptoms such as hypotension, palpitations, dyspnoea, and oedema have been reported during marketed use of liraglutide.
Slovenian: Po prihodu liraglutida na trg so poročali o nekaj primerih anafilaktičnih reakcij z dodatnimi simptomi, kot so hipotenzija, palpitacije, dispneja in edem.
English: • Put the pen cap on your pen after each use to protect the solution from light.
Slovenian: • Po vsaki uporabi pokrijte injekcijski peresnik s pokrovčkom, da zaščitite raztopino pred svetlobo.
English: Figure 4 Mean HbA1c (%) by treatment week in patients with type 2 diabetes mellitus inadequately controlled on insulin glargine
Slovenian: Slika 4: Povprečna vrednost HbA1c (%) po tednih zdravljenja pri bolnikih z nezadostno urejeno sladkorno boleznijo tipa 2 pri zdravljenju z insulinom glargin
English: No cardiovascular outcomes trials have been performed with Xultophy.
Slovenian: • Srčno-žilna varnost Preskušanj srčno-žilnih izidov z zdravilom Xultophy niso izvedli.
English: The contraceptive effect is therefore anticipated to be unaffected when co-administered with liraglutide.
Slovenian: Pri sočasni uporabi liraglutida vpliva na učinek kontracepcije ni pričakovati.
English: Other side effects include: Common (may affect up to 1 in 10 people)
Slovenian: Pogosti (pojavijo se lahko pri največ 1 od 10 bolnikov)
English: Lisinopril median tmax was delayed from 6 h to 8 h with liraglutide.
Slovenian: Pri uporabi skupaj z liraglutidom se je mediani čas do največje koncentracije (tmax) lizinoprila s 6 ur podaljšal na 8 ur.
English: Xultophy is administered as dose steps.
Slovenian: Zdravilo Xultophy se aplicira v odmernih korakih.
English: You may see a drop of solution at the needle tip after injecting.
Slovenian: Po injiciranju lahko na konici igle opazite kapljico raztopine.
English: Pioglitazone should be discontinued if any deterioration in cardiac symptoms occurs.
Slovenian: Če se srčni simptomi kakor koli poslabšajo, je treba zdravljenje s pioglitazonom ukiniti.
English: The key results of the trial are listed in Figure 1 and Table 3.
Slovenian: Ključni rezultati preskušanja so prikazani na sliki 1 in v preglednici 3.
English: If you forget a dose, inject the missed dose when discovering the mistake, ensuring a minimum of
Slovenian: Če ste pozabili injicirati odmerek, ga injicirajte, ko se na to spomnite, vendar pa morate zagotoviti, da med posameznimi odmerki mine najmanj 8 ur.
English: Hydrochloric acid (for pH adjustment) Sodium hydroxide (for pH adjustment) Water for injections
Slovenian: FARMACEVTSKI PODATKI 6.1 Seznam pomožnih snovi glicerol fenol cinkov acetat klorovodikova kislina (za uravnavanje pH) natrijev hidroksid (za uravnavanje pH) voda za injekcije
English: Insulin degludec, maximum 50 units allowed
Slovenian: insulina degludek pa 50 enot.
English: Your blood sugar level may fall if you take:
Slovenian: Koncentracija krvnega sladkorja se lahko zmanjša, če jemljete:
English: IDegLira obs. rate IDegLira IDeg
Slovenian: IDegLira op. delež IDegLira
English: Mean increase in heart rate from baseline of 2 to 3 beats per minute has been observed in clinical trials with Xultophy.
Slovenian: Srčni utrip se je od izhodišča v povprečju povečal za 2 do 3 utripe na minuto.
English: One dose step contains 1 unit of insulin degludec and 0.036 mg of liraglutide.
Slovenian: En odmerni korak vsebuje 1 enoto insulina degludek in 0,036 mg liraglutida.
English: You should stop your basal insulin treatment prior to starting on Xultophy.
Slovenian: Pred začetkom zdravljenja z zdravilom Xultophy morate zdravljenje z bazalnim insulinom prekiniti.
English: The key results of the trial are listed in Figure 2 and Table 3.
Slovenian: Ključni rezultati preskušanja so prikazani na sliki 2 in v preglednici 3.
English: Novo Allé, Bagsværd, 2880, Denmark Name and address of the manufacturer responsible for batch release Novo Nordisk A/S
Slovenian: Ime in naslov izdelovalca, odgovornega za sproščanje serij Novo Nordisk A/S
English: 3 Select your dose • Turn the dose selector to select the dose you need.
Slovenian: • Zavrtite izbirnik odmerka, da boste izbrali predpisani odmerek.
English: Figure 5 Mean HbA1c (%) by treatment week in patients with type 2 diabetes mellitus inadequately controlled on basal insulin
Slovenian: Slika 5: Povprečna vrednost HbA1c (%) po tednih zdravljenja pri bolnikih z nezadostno urejeno sladkorno boleznijo tipa 2 pri zdravljenju z bazalnim insulinom
English: Xultophy 100 units/mL + 3.6 mg/mL solution for injection.
Slovenian: Xultophy 100 enot/ml + 3,6 mg/ml raztopina za injiciranje
English: 100 units/mL + 3.6 mg/mL, then look at the illustrations below to get to know the different parts of your pen and needle.
Slovenian: Najprej preverite, če injekcijski peresnik vsebuje zdravilo Xultophy 100 enot/ml + 3,6 mg/ml, nato pa se s pomočjo slik v nadaljevanju seznanite z različnimi deli injekcijskega peresnika in injekcijske igle.
English: • To see precisely how much solution is left, use the dose counter:
Slovenian: • Preostalo količino raztopine lahko natančno preverite s pomočjo števca odmerka.
English: Recommended for use with NovoTwist or NovoFine disposable needles Needles are not included
Slovenian: POSTOPEK IN POT UPORABE ZDRAVILA Priporočamo uporabo injekcijskih igel NovoTwist ali NovoFine za enkratno uporabo.
English: It contains 3 mL of Xultophy solution.
Slovenian: Vsebuje 3 ml raztopine zdravila Xultophy in omogoča odmerjanje:
English: The rate per patient year of exposure (percentage of patients) of severe hypoglycaemia was 0.00 (0 patients out of 278) for Xultophy and 0.01 (1 patient out of 279) for insulin glargine.
Slovenian: Xultophy 0,00 (0 od 278 bolnikov), pri insulinu glargin pa 0,01 (1 od 279 bolnikov).
English: One dose step contains 1 unit insulin degludec + 0.036 mg liraglutide.
Slovenian: 1 enoto insulina degludek + 0,036 mg liraglutida.
English: Favours insulin degludec
Slovenian: Okvara ledvic Insulin degludek
English: The key results of the trial are listed in Figure 4 and Table 5.
Slovenian: Ključni rezultati preskušanja so prikazani na sliki 4 in v preglednici 5.
English: Liraglutide did not change the overall exposure of paracetamol following a single dose of 1,000 mg. Paracetamol Cmax was decreased by 31% and median tmax was delayed up to 15 min. No dose adjustment for concomitant use of paracetamol is required.
Slovenian: Največja koncentracija (Cmax) paracetamola se je zmanjšala za 31 %, mediani čas do največje koncentracije (tmax) pa se je podaljšal za največ 15 minut.
English: There is no difference in the pharmacokinetics of insulin degludec between healthy subjects and patients with renal impairment.
Slovenian: Pri bolnikih z okvaro ledvic se farmakokinetika insulina degludek ne razlikuje od farmakokinetike pri zdravih osebah.
English: Always check the pen label before you inject your medicine to ensure that you use the correct pen.
Slovenian: Pred vsakim injiciranjem zdravila vedno preverite nalepko na injekcijskem peresniku, da se prepričate,
English: There is no therapeutic experience in patients with congestive heart failure New York Heart Association (NYHA) class IV and Xultophy is therefore not recommended for use in these patients.
Slovenian: Association (NYHA) ni, zato uporaba zdravila Xultophy pri teh bolnikih ni priporočljiva.
English: • Push the needle straight onto the pen.
Slovenian: • Injekcijsko iglo potisnite naravnost na injekcijski peresnik in jo trdno privijte.
English: This makes sure that the solution flows.
Slovenian: To zagotavlja pretok raztopine.
English: Dose selector Dose button
Slovenian: 3 Izberite odmerek
English: Dose End of trial Insulin degludec (units) Liraglutide (mg) Estimated difference, insulin degludec dose
Slovenian: Liraglutid (mg) Ocenjena razlika, odmerek insulina degludek
English: • Glycaemic control
Slovenian: • Uravnavanje glikemije
English: Your blood sugar level may rise if you take:
Slovenian: Koncentracija krvnega sladkorja se lahko zveča, če jemljete:
English: 3 mL solution in a cartridge (type 1 glass) with a plunger (halobutyl) and a stopper (halobutyl/polyisoprene) contained in a pre-filled multidose disposable pen made of polypropylene, polycarbonate and acrylonitrile butadiene styrene.
Slovenian: (halobutil/poliizopren) v večodmernem napolnjenem injekcijskem peresniku iz polipropilena, polikarbonata in akrilonitril butadien stirena, ki se ga zavrže.
English: Xultophy 100 units/mL + 3.6 mg/mL solution for injection insulin degludec + liraglutide SC use
Slovenian: Xultophy 100 enot/ml + 3,6 mg/ml raztopina za injiciranje insulin degludek + liraglutid za s.c. uporabo
English: Liraglutide stimulates insulin secretion and lowers inappropriately high glucagon secretion in a glucose-dependent manner.
Slovenian: Liraglutid v odvisnosti od koncentracije glukoze spodbuja izločanje insulina in zmanjšuje neprimerno veliko izločanje glukagona.
English: Xultophy 100 units/mL + 3.6 mg/mL solution for injection insulin degludec + liraglutide
Slovenian: Xultophy 100 enot/ml + 3,6 mg/ml raztopina za injiciranje insulin degludek + liraglutid
English: IDegLira Placebo
Slovenian: Placebo
English: Hypoglycaemia
Slovenian: Hiperglikemija
English: Degradation of insulin degludec is similar to that of human insulin; all metabolites formed are inactive.
Slovenian: Razgradnja insulina degludek je podobna razgradnji človeškega insulina.
English: • Inflamed gallbladder.
Slovenian: • žolčni kamni • vnetje žolčnika
English: The key results of the trial are listed in Figure 3 and Table 4.
Slovenian: Ključni rezultati preskušanja so prikazani na sliki 3 in v preglednici 4.
English: After first opening: Store at a maximum of 30°C or store in a refrigerator Keep the cap on the pen to protect from light
Slovenian: Po prvem odprtju: shranjujte pri temperaturi do 30 °C ali v hladilniku.
English: Talk to your doctor, pharmacist or nurse before using Xultophy.
Slovenian: Opozorila in previdnostni ukrepi Pred začetkom uporabe zdravila Xultophy se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Liraglutide lowered ethinylestradiol and levonorgestrel Cmax by 12 and 13%, respectively, following administration of a single dose of an oral contraceptive product.
Slovenian: Liraglutid je po enkratnem odmerku peroralnega kontraceptiva zmanjšal največjo koncentracijo (Cmax) etinilestradiola za 12 %, največjo koncentracijo (Cmax) levonorgestrela pa za 13 %.
English: Liraglutide did not change the overall exposure of griseofulvin following administration of a single dose of griseofulvin 500 mg. Griseofulvin Cmax increased by 37% while median tmax did not change.
Slovenian: Največja koncentracija (Cmax) griseofulvina se je povečala za 37 %, mediani čas do največje koncentracije (tmax) pa se ni spremenil.
English: EU/1/14/947/001 1 pre-filled pen EU/1/14/947/002 3 pre-filled pens EU/1/14/947/003 5 pre-filled pens
Slovenian: EU/1/14/947/003 5 napolnjenih injekcijskih peresnikov
English: You can carry Xultophy with you and keep it at room temperature (no more than 30°C) or in a refrigerator (2°C to 8°C) for up to 21 days.
Slovenian: 30 °C) ali v hladilniku (2 °C − 8 °C) največ 21 dni.