FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Medicines Agency decided that, in accordance with EU requirements for biosimilar medicines, Abseamed has a highly similar structure, purity and biological activity to Eprex/Erypo and is distributed in the body in the same way.
Croatian: Europska agencija za lijekove zaključila je kako, u skladu sa zahtjevima EU-a za bioslične lijekove, lijek Abseamed ima vrlo sličnu strukturu, čistoću i biološku aktivnost kao i lijek Eprex/Erypo te se u tijelu raspoređuje na isti način.
English: The dose, the frequency of injection and how long it is used for also depend on why Abseamed is being used and on the patient's bodyweight, and are adjusted according to how well the medicine is working.
Croatian: Doza, učestalost injektiranja i trajanje primjene također ovise o razlogu primjene lijeka Abseamed i tjelesnoj težini bolesnika te se primjenjuju u skladu s djelovanjem lijeka.
English: • to reduce the need for blood transfusions in adults with moderate anaemia who are about to undergo major orthopaedic (bone) surgery, such as hip surgery.
Croatian: • za smanjenje potrebe za krvnim transfuzijama u odraslih osoba s umjerenom anemijom koji trebaju ići na veći ortopedski (koštani) kirurški zahvat, poput operacije kuka.
English: What benefits of Abseamed have been shown in studies?
Croatian: Koje su koristi od lijeka Abseamed utvrđene u ispitivanjima?
English: Therefore the Agency's view was that, as for Eprex/Erypo, the benefit of Abseamed outweighs the identified risk and it can be authorised.
Croatian: Stoga je stav Agencije da korist kod lijeka Abseamed, kao i kod lijeka Eprex/Erypo, nadmašuje identificirani rizik te da lijek može biti odobren.
English: Another study showed that Abseamed injected under the skin was as effective in maintaining haemoglobin levels as Eprex/Erypo in 114 cancer patients who were receiving chemotherapy.
Croatian: Drugo ispitivanje također je pokazalo da je lijek Abseamed ubrizgan pod kožu bio jednako učinkovit u zadržavanju razina hemoglobina kao i Eprex/Erypo u 114 bolesnika s karcinomom koji su primali kemoterapiju.
English: In addition, studies have shown that the effects of the medicine are equivalent to those of Eprex/Erypo in increasing and maintaining blood cell counts in patients with chronic kidney failure or undergoing chemotherapy.
Croatian: Nadalje, ispitivanjem je dokazano da su učinci lijeka jednakovrijedni učincima lijeka Eprex/Erypo u povećanju i zadržavanju broja krvnih stanica u bolesnika s kroničnim zatajenjem bubrega ili bolesnika koji primaju kemoterapiju.
English: Laboratory studies comparing Abseamed with the reference medicine Eprex/Erypo have shown that the active substance in Abseamed is highly similar to that in Eprex/Erypo in terms of structure, purity and biological activity.
Croatian: Laboratorijska ispitivanja u kojima je lijek Abseamed uspoređivan s referentnim lijekom Eprex/Erypo pokazala su da je djelatna tvar u lijeku Abseamed vrlo slična djelatnoj tvari u lijeku Eprex/Erypo u pogledu strukture, čistoće i biološke aktivnosti.
English: • patients who have developed pure red cell aplasia (reduced or stopped red blood cell production)
Croatian: • bolesnika koji su razvili čistu aplaziju krvnih stanica (smanjena proizvodnja crvenih krvnih stanica ili prestanak njihove proizvodnje) nakon terapije eritropoetinom;
English: Patients switching to Abseamed maintained haemoglobin levels to the same extent as those continuing with Eprex/Erypo.
Croatian: Bolesnici koji su počeli uzimati lijek Abseamed zadržali su razine hemoglobina u istoj mjeri kao i bolesnici koji su nastavili uzimati Eprex/Erypo.
English: In addition, Abseamed was shown to be as effective as Eprex/Erypo at increasing and maintaining red blood cell counts in several studies.
Croatian: Nadalje, u nekoliko se ispitivanja pokazalo da je lijek Abseamed jednako učinkovit kao Eprex/Erypo u povećanju i zadržavanju broja crvenih krvnih stanica.
English: Studies have also shown that giving Abseamed produces similar levels of the active substance in the body to giving Eprex/Erypo.
Croatian: Ispitivanja su pokazala i da primjena lijeka Abseamed dovodi do slične razine djelatne tvari u tijelu kao i primjena lijeka Eprex/Erypo.
English: How does Abseamed work?
Croatian: Kako djeluje Abseamed?
English: For the full list of side effects of Abseamed, see the package leaflet.
Croatian: Potpuni popis nuspojava zabilježenih pri primjeni lijeka Abseamed potražite u uputi o lijeku.
English: BEFORE YOU START
Croatian: PRIJE NEGO ŠTO POČNETE
English: An observer is someone who:
Croatian: Promatrač je osoba koja:
English: There may be new information.
Croatian: Mogu postojati nove informacije.
English: Most people respond within 18 months, but it can sometimes take up to 30 months.
Croatian: Većina ljudi odgovori unutar 18 mjeseci, ali nekad može biti potrebno i do 30 mjeseci.
English: o Your doctor will tell you if you need an observer for longer than 6 months.
Croatian: o Liječnik će Vam reći ako Vam je promatrač potreban duže od 6 mjeseci.
English: It is normal to see an air bubble.
Croatian: Normalno je vidjeti mjehuriće zraka.
English: Relatively low titres of IgE has also been observed.
Croatian: Također su zabilježeni relativno niski titri IgE.
English: If more than one syringe is needed:
Croatian: Ako je potrebno više od jedne štrcaljke:
English: The time to reach a response ranged from 0.5 to 30 months.
Croatian: Vrijeme do postizanja odgovora bilo je u rasponu od 0,5 do 30 mjeseci.
English: Tell your doctor that you had a severe allergic reaction.
Croatian: Recite svom liječniku da ste imali tešku alergijsku reakciju.
English: No vacuolation was observed in the brain.
Croatian: Vakuolizacija nije zapažena u mozgu.
English: Duration prior to next dose increase
Croatian: Trajanje prije sljedećeg povećanja doze
English: Prior to independent self-injection, a healthcare professional should:
Croatian: Prije samostalnog injiciranja lijeka, zdravstveni radnik treba:
English: The recommended injection sites are:
Croatian: Preporučena mjesta injiciranja su:
English: The absolute bioavailability in humans is unknown.
Croatian: Apsolutna bioraspoloživost u ljudi nije poznata.
English: Individual values for half-life range from 14 to 132 hours.
Croatian: Raspon individualnih vrijednosti poluvijeka je od 14 do 132 sata.
English: No differences in the safety profile were observed.
Croatian: Nisu zamijećene razlike u sigurnosnom profilu.
English: Study 302: Efficacy assessment
Croatian: Ispitivanje 302: Procjena učinkovitosti
English: Serious side effects include:
Croatian: Ozbiljne nuspojave uključuju:
English: The immune response stabilises over 6 to 9 months of total treatment.
Croatian: Imunološki odgovor stabilizira se tijekom 6 do 9 mjeseci ukupnog liječenja.
English: • Note: Do not inject multiple injections in the same spot.
Croatian: • Napomena: Nemojte injicirati više injekcija u isto mjesto.
English: Osmolality: 260 - 290 mOsm/kg
Croatian: Osmolalnost: 260 - 290 mOsm/kg
English: • Do not change your protein intake unless your doctor tells you to.
Croatian: • Nemojte mijenjati svoj unos proteina osim ako Vam je to rekao liječnik.
English: It can be on the same part of the body or a different part of the body (see Figures E and F).
Croatian: Može biti na istom ili na različitom dijelu tijela (pogledajte slike E i F).
English: If you miss a dose, take your next dose at the regular time.
Croatian: Ako zaboravite primijeniti dozu, sljedeću dozu uzmite u uobičajeno vrijeme.
English: Your doctor will tell you how long to stay at each dose.
Croatian: Liječnik će Vam reći koliko ćete dugo ostati na istoj dozi.
English: Dose titration and time to achieve response
Croatian: Titracija doze i vrijeme do postizanja odgovora
English: Release the pinch of skin.
Croatian: Otpustite nabor kože.
English: Keep it with you at all times.
Croatian: Uvijek ga nosite sa sobom.
English: Table 1: Recommended dosing regimen
Croatian: Tablica 1: Preporučeni režim doziranja
English: Also, talk to your healthcare provider about your medical condition or your treatment.
Croatian: Razgovarajte, također, sa svojim liječnikom o svom zdravstvenom stanju i svom liječenju.
English: Slowly increasing your dose over time allows your body to adjust to this medicine.
Croatian: Postupno povećanje doze tijekom vremena omogućuje Vašem tijelu da se postupno prilagodi lijeku.
English: - Place each sealed tray on a clean, flat surface out of reach of children and pets.
Croatian: - Svaki zatvoreni podložak stavite na čistu, ravnu površinu izvan dohvata djece i životinja.
English: An additional 7% of patients responded to Palynziq after 18 months of treatment.
Croatian: Dodatnih 7% bolesnika odgovorilo je na Palynziq nakon 18 mjeseci liječenja.
English: - Do not warm up the pre-filled syringe in any other way.
Croatian: - Nemojte zagrijavati napunjenu štrcaljku na bilo koji drugi način.
English: Overall treatment experience from Study 301 and Study 302
Croatian: Ukupno iskustvo liječenja iz Ispitivanja 301 i Ispitivanja 302
English: If the expiry date has passed, do not use the pre-filled syringe in that carton.
Croatian: Ako je rok valjanosti istekao, nemojte koristiti napunjenu štrcaljku iz te kutije.
English: Do not use a microwave and do not place in hot water.
Croatian: Nemojte koristiti mikrovalnu pećnicu ili stavljati štrcaljku u vruću vodu.
English: Symptoms of inattention and mood were also evaluated during this period.
Croatian: Tijekom tog razdoblja procijenjeni su i simptomi nepažnje i raspoloženja.
English: These patients received the same induction/titration/maintenance regimen as patients aged 18 years and older in this study.
Croatian: Ti su bolesnici primali isti režim indukcije/titracije/održavanja kao i bolesnici u dobi od 18 godina i stariji u ovom ispitivanju.
English: These medicines help to reduce the symptoms of an allergic reaction.
Croatian: Ti lijekovi pomažu ublažiti simptome alergijske reakcije.
English: The majority of patients (66%) reached a response by 18 months of total treatment.
Croatian: Većina bolesnika (66%) postigla je odgovor unutar 18 mjeseci ukupnog liječenja.
English: The average molecular mass is approximately 1,000 kDa of which the protein moiety constitutes approximately 248 kDa.
Croatian: Prosječna molekularna masa iznosi približno 1000 kDa od čega je proteinski dio približno 248 kDa.
English: The median duration was 161 days (range: 35, 1408).
Croatian: Medijan trajanja bio je 161 dan (raspon: 35, 1408).
English: • Do not touch the cleaned injection site.
Croatian: • Nemojte dodirivati očišćeno mjesto injiciranja.
English: Step 15: Treat injection site (if needed).
Croatian: Korak 15: Pobrinite se za mjesto injiciranja (ako je potrebno).
English: • Do not flick or try to push the bubble out.
Croatian: • Nemojte tapkati ili pokušati potisnuti mjehurić van.
English: The effects in offspring were associated with maternal toxicity.
Croatian: Učinak na potomstvo povezan je s toksičnosti u majke.
English: Frequencies are defined as: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data).
Croatian: Učestalosti su definirane kao: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Hold the skin firmly (see Figure K).
Croatian: Držite kožu čvrsto (pogledajte Sliku K).
English: Specific populations
Croatian: Specifične populacije
English: After 6 months of Palynziq treatment, the need for an observer may be reconsidered.
Croatian: Nakon 6 mjeseci liječenja lijekom Palynziq, potrebu za promatračem može se ponovno razmotriti.
English: BioMarin Pharmaceutical Inc. Galli Drive Facility 46 Galli Drive
Croatian: Galli Drive Facility 46 Galli Drive
English: Gather your supplies for the injection and place them on a clean flat surface.
Croatian: Pripremite svoj pribor za injekciju i stavite ga na čistu ravnu površinu.
English: Date removed from refrigeration: _____/_____/______
Croatian: Datum vađenja iz hladnjaka: _____/_____/______
English: Based on its mechanism of action, pegvaliase is not expected to be tumorigenic.
Croatian: Na temelju mehanizma djelovanja, ne očekuje se da će pegvaliaza biti tumorogena.
English: Long-term studies in animals to evaluate carcinogenic potential or studies to evaluate mutagenic potential have not been performed with pegvaliase.
Croatian: Dugoročna ispitivanja u životinja za ocjenu kancerogenog potencijala ili ispitivanja za ocjenu mutagenog potencijala nisu obavljena s pegvaliazom.
English: Cutaneous reactions (not limited to the injection site) lasting ≥ 14 days
Croatian: Kožne reakcije (koje nisu ograničene na mjesto primjene injekcije) trajanja ≥ 14 dana
English: What Palynziq is and what it is used for
Croatian: Što je Palynziq i za što se koristi
English: Anti-PAL IgG was detected in almost all patients by 4 months.
Croatian: Anti-PAL IgG otkriven je u gotovo svih bolesnika do 4. mjeseca.
English: The clinical significance of these findings and functional consequences are unknown.
Croatian: Klinički značaj i funkcionalne posljedice tih zapažanja nisu poznate.
English: The potency of this medicinal product should not be compared to any other PEGylated or non-PEGylated protein of the same therapeutic class.
Croatian: Potentnost ovog lijeka ne smije se uspoređivati s potentnosti drugih pegiliranih ili nepegiliranih proteina iste terapijske skupine.
English: Trouble swallowing or speaking
Croatian: Poteškoće s gutanjem ili govorom
English: Step 7: Wash your hands well with soap and water (see Figure G).
Croatian: Korak 7: Operite ruke sapunom i vodom (pogledajte Sliku G).
English: Patients should be instructed to pre-medicate with an H1-receptor antagonist, H2-receptor antagonist, and antipyretic.
Croatian: Bolesnike treba uputiti na premedikaciju antagonistom H1 receptora, antagonistom H2 receptora i antipiretikom.
English: • Front middle of the thighs.
Croatian: • Sredina prednjeg dijela bedara.
English: Some of these allergic reactions can be more serious, as described below, and will require immediate attention.
Croatian: Neke od tih alergijskih reakcija mogu biti ozbiljnije, kako je opisano u nastavku, i za njih je potreban hitan liječnički nadzor.
English: Do not share your pre-filled syringes with anyone else.
Croatian: Svoje napunjene štrcaljke ne dijelite s drugim osobama.
English: In maintenance phase of the treatment, steady state is expected 4 to 24 weeks after maintenance dose started.
Croatian: U fazi održavanja liječenja, stanje dinamičke ravnoteže očekuje se 4 do 24 tjedna nakon početka primjene doze održavanja.
English: Efficacy results over time are presented in Table 4 and Figure 1.
Croatian: Rezultati djelotvornosti tijekom vremena prikazani su u Tablici 4 i na Slici 1.
English: Let the skin air dry for at least 10 seconds before injecting (see Figure H).
Croatian: Pustite kožu da se osuši na zraku 10 sekundi prije injiciranja (pogledajte Sliku H).
English: • Do not use the pre-filled syringe if it looks damaged or used.
Croatian: • Nemojte upotrijebiti napunjenu štrcaljku ako izgleda oštećena ili korištena.
English: It is not known if Palynziq passes into breast milk or if it will affect your baby.
Croatian: Nije poznato prelazi li Palynziq u majčino mlijeko i hoće li utjecati na Vašu bebu.
English: Study 302 RDT Week 8
Croatian: Ispitivanje 302 RDT 8. tjedan
English: • Each day, change (rotate) your injection sites.
Croatian: • Mjesto injiciranja promijenite (rotirajte) svaki dan.
English: Due to lack of human data, Palynziq should only be administered to breast-feeding women if the potential benefit is considered to outweigh the potential risk to the infant.
Croatian: Zbog nedostatka podataka o primjeni u ljudi, Palynziq treba primijeniti u dojilja samo ako se smatra da potencijalna korist nadmašuje potencijalni rizik za dojenče.
English: 4 Change from baseline was based on subjects with available measurements at both time points.
Croatian: 4 Promjena u odnosu na početnu vrijednost temeljila se na ispitanicima s dostupnim mjerenjima u obje vremenske točke.
English: The bioavailability is not affected by the different injection sites on the body (see section 4.2).
Croatian: Na bioraspoloživost ne utječu različita mjesta injiciranja na tijelu (vidjeti dio 4.2).
English: Do not take two doses of Palynziq to make up for a missed dose.
Croatian: Nemojte uzeti dvije doze lijeka Palynziq kako biste nadoknadili propuštenu dozu.
English: Step 5: Check syringe strength and check for particles:
Croatian: Korak 5: Provjerite jačinu štrcaljke i provjerite ima li čestica:
English: The duration of titration varied among patients and was based on patient tolerability (up to 30 weeks).
Croatian: Trajanje titracije variralo je među bolesnicima i temeljilo se na podnošljivosti bolesnika (do 30 tjedana).
English: Vacuoles in all tissues, with the exception of the kidney, resolved or were diminished by the end of the recovery period, suggesting partial reversibility.
Croatian: Vakuole u svim tkivima, s izuzećem bubrega, smanjile su se ili povukle do kraja razdoblja oporavka, što sugerira parcijalnu reverzibilnost.
English: Step 11: Hold the body of the pre-filled syringe in 1 hand between your thumb and index finger.
Croatian: Korak 11: Držite tijelo štrcaljke jednom rukom, između palca i kažiprsta.
English: The vacuolation observed in these studies was not associated with any organ related toxicities as determined by clinical chemistry/urinalysis and histopathological analysis.
Croatian: Vakuolizacija zabilježena u tim ispitivanjima nije bila povezana s bilo kakvom toksičnosti vezanom uz organe, što je utvrđeno kliničkom kemijom/analizom urina i histopatološkom analizom.
English: In clinical trials, doses of pegvaliase were explored up to 150 mg/day and no specific signs or symptoms were identified following these higher doses.
Croatian: U kliničkim ispitivanjima, ispitivane su doze pegvaliaze do 150 mg/dan i nakon tih viših doza nisu zabilježeni specifični znakovi ili simptomi.
English: You will use the 2.5 mg syringe once a week for at least the first 4 weeks.
Croatian: Primijenit ćete štrcaljku od 2,5 mg jednom tjedno tijekom najmanje prva 4 tjedna.
English: Doses should not be divided over the course of the day
Croatian: Doze se ne smiju podijeliti na manje doze tijekom dana.
English: If your phenylalanine levels are too high or too low during pregnancy, this may harm you or your baby.
Croatian: Previsoke ili preniske razine fenilalanina u krvi tijekom trudnoće mogu naškoditi Vama ili Vašoj bebi.
English: The long-term clinical consequences of chronic hypophenylalaninaemia are unknown.
Croatian: Dugoročne kliničke posljedice kronične hipofenilalaninemije nisu poznate.
English: • would be present with the patient during and after Palynziq administration,
Croatian: • je prisutna s bolesnikom tijekom i nakon primjene lijeka Palynziq,
English: Additional risk to the unborn child due to hypophenylalaninaemia is not established.
Croatian: Dodatni rizik za nerođeno dijete zbog hipofenilalaninemije nije utvrđen.
English: Linearity/nonlinearity
Croatian: Linearnost/nelinearnost
English: Thus, mean dose levels also stabilized with long-term treatment with sustained therapeutic effect.
Croatian: Tako su se srednje vrijednosti visine doze također stabilizirale dugotrajnim liječenjem s održanim terapijskim učinkom.
English: Record the date removed from refrigeration on the unopened product tray.
Croatian: Zabilježite datum vađenja iz hladnjaka na neotvorenom podlošku proizvoda.
English: Angioedema can also present as one of the symptoms of an acute systemic hypersensitivity reaction.
Croatian: Angioedem se također može prezentirati kao jedan od simptoma akutne sistemske reakcije preosjetljivosti.
English: Palynziq is given as an injection under the skin (subcutaneous injection).
Croatian: Palynziq se primjenjuje kao injekcija ispod kože (supkutana injekcija).
English: Osmolality: 285 - 315 mOsm/kg, viscous solution
Croatian: Osmolalnost: 285 - 315 mOsm/kg, viskozna otopina
English: Your healthcare provider will also tell you which signs and symptoms to look out for and what to do if you have a severe allergic reaction.
Croatian: Zdravstveni radnik će Vam također reći na koje znakove i simptome treba paziti i što učiniti ako dobijete tešku alergijsku reakciju.
English: Check with your doctor, pharmacist or nurse about the right way to throw away the container.
Croatian: Provjerite sa svojim liječnikom, ljekarnikom ili medicinskom sestrom ispravan način odlaganja spremnika.
English: In the pups of these animals, systemic exposure of pegvaliase was not detected.
Croatian: U mladunčadi ovih životinja, sistemska izloženost pegvaliazi nije pronađena.
English: Do not wipe it away.
Croatian: Nemojte je brisati.
English: Check the syringe label to make sure you have the correct strength for your prescribed dose.
Croatian: Provjerite naljepnicu štrcaljke kako biste bili sigurni da imate odgovarajuću jačinu za Vama propisanu dozu.
English: Seven out of the 16 patients discontinued treatment.
Croatian: Od tih 16 bolesnika, 7 je prekinulo liječenje.
English: The mean duration of serum sickness was 5 days and ranged from 1 to 8 days.
Croatian: Srednja vrijednost trajanja serumske bolesti bila je 5 dana u rasponu od 1 do 8 dana.
English: Dispose of the used syringes
Croatian: Odložite upotrijebljene štrcaljke
English: Prior to launch of Palynziq in each Member State, the Marketing Authorisation Holder (MAH) must agree about the content and format of the educational programme, including communication media, distribution modalities, and any other aspects of the programme, with the National Competent Authority.
Croatian: Prije stavljanja u promet lijeka Palynziq u svakoj zemlji članici, nositelj odobrenja mora s nacionalnim nadležnim tijelom dogovoriti sadržaj i format edukacijskog programa, uključujući komunikacijske medije, modalitete distribucije i sve druge aspekte programa.
English: Three out of 7 (1%) patients had severe serum sickness (see section 4.8).
Croatian: Tri od 7 (1%) bolesnika imalo je tešku serumsku bolest (vidjeti dio 4.8).
English: For this study, the maintenance period was defined as at least 3 weeks dosing at randomised 20 mg or 40 mg once daily.
Croatian: Za ovo ispitivanje, razdoblje održavanja definirano je kao najmanje 3 tjedna doziranja randomiziranih 20 mg ili 40 mg jednom dnevno.
English: • Stop injecting Palynziq if any of the following symptoms occur.
Croatian: • Prestanite primjenjivati lijek Palynziq ako se pojavi bilo koji od sljedećih simptoma.
English: 6 Reflects high sensitivity CRP (hsCRP) levels above upper limit of normal (greater than 0.287 mg/dl) over a 6 month period.
Croatian: 6 Odnosi se na koncentracije CRP-a visoke osjetljivosti (engl. high sensitivity CRP, hsCRP) iznad gornje granice normale (veće od 0,287 mg/dl) tijekom razdoblja od 6 mjeseci.
English: Look at the liquid through the viewing window (see Figure D).
Croatian: Provjerite tekućinu kroz prozorčić (pogledajte Sliku D).
English: - Open each carton and take out the sealed tray you need for your dose.
Croatian: - Otvorite svaku kutiju i izvadite zatvoreni podložak potreban za dozu koja Vam je propisana.
English: Stop injecting Palynziq if you notice any serious sudden signs of allergy or combination of signs listed below.
Croatian: Prestanite primjenjivati injekcije lijeka Palynziq ako primijetite bilo koje ozbiljne iznenadne znakove alergije ili kombinaciju znakova navedenih u nastavku.
English: Following a single subcutaneous dose (0.01, 0.03 or 0.1 mg/kg), pegvaliase is absorbed slowly with a median tmax of 3.5 to 4 days (individual range of 2.5 to 7 days).
Croatian: Nakon pojedinačne supkutane doze (0,01, 0,03 ili 0,1 mg/kg), pegvaliaza se apsorbira polako s medijanom tmax od 3,5 do 4 dana (individualni raspon od 2,5 do 7 dana).
English: Do not use a Palynziq syringe more than once.
Croatian: Nemojte koristiti štrcaljku lijeka Palynziq više od jednom.
English: Place the thumb of your other hand on the plunger head (see Figure L).
Croatian: Palac druge ruke stavite na glavu klipa (pogledajte Sliku L).