FrancophonIA/ELRC3.0 huggingface dataset:
English: In controlled Phase 3 trials of adalimumab in patients with rheumatoid arthritis and psoriatic arthritis with a control period duration ranging from 4 to 104 weeks, ALT elevations ≥ 3 x ULN occurred in 3.7% of adalimumab-treated patients and 1.6% of control-treated patients.
Croatian: U kontroliranim ispitivanjima faze III u kojima se adalimumab primjenjivao u bolesnika s reumatoidnim artritisom i psorijatičnim artritisom, s kontrolnim razdobljem koje je trajalo u rasponu od 4 do 104 tjedna, povišenje razine ALT-a ≥ 3 × GGN (gornja granica normalnog raspona) zabilježeno je u 3,7% bolesnika liječenih adalimumabom i 1,6% bolesnika iz kontrolne skupine.
English: 1 sterile injection syringe
Croatian: 1 sterilnu štrcaljku za injekciju 1 sterilnu iglu
English: Following subcutaneous administration of 40 mg of adalimumab every other week in adult rheumatoid arthritis (RA) patients the mean steady-state trough concentrations were approximately 5 μg/ml (without concomitant methotrexate) and 8 to 9 μg/ml (with concomitant methotrexate), respectively.
Croatian: Nakon supkutane primjene adalimumaba u dozi od 40 mg svaka dva tjedna u odraslih bolesnika s reumatoidnim artritisom srednje vrijednosti najniže koncentracije lijeka u stanju dinamičke ravnoteže bile su približno 5 µg/ml (bez istodobne primjene metotreksata), odnosno 8 do 9 µg/ml (uz metotreksat).
English: Adolescents with hidradenitis suppurativa from 12 years of age, weighing at least 30 kg
Croatian: Adolescenti s gnojnim hidradenitisom u dobi od 12 godina i stariji, tjelesne težine najmanje 30 kg
English: Table 6: Undesirable Effects
Croatian: Tablica 6: Nuspojave
English: Opportunistic infections, including invasive fungal infections have been observed in patients receiving adalimumab.
Croatian: U bolesnika koji su primali adalimumab zabilježene su oportunističke infekcije, uključujući invazivne gljivične infekcije.
English: JSN score a p-value is from the pairwise comparison of methotrexate monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test. b p-value is from the pairwise comparison of adalimumab monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test c p-value is from the pairwise comparison of adalimumab monotherapy and methotrexate monotherapy using the Mann-Whitney U test
Croatian: JSN rezultat a p-vrijednost dobivena sparenom usporedbom monoterapije metotreksatom i kombinirane terapije adalimumabom i metotreksatom uz primjenu Mann-Whitney U testa.
English: Vertigo and visual impairment may occur following administration of Hulio (see section 4.8).
Croatian: Nakon primjene lijeka Hulio mogu se pojaviti vrtoglavica i poremećaji vida (vidjeti dio 4.8).
English: Your child's doctor may also prescribe an initial dose of 80 mg which may be administered one week prior to the start of the usual dose.
Croatian: Liječnik Vašeg djeteta možda će propisati i početnu dozu od 80 mg, koja se može primijeniti tjedan dana prije početka primjene uobičajene doze.
English: Children and adolescents from 2 to 17 years of age weighing 30 kg or more: The usual dose of Hulio is 40 mg every other week with methotrexate.
Croatian: Djeca i adolescenti u dobi od 2 do 17 godina, tjelesne težine 30 kg ili više: Uobičajena doza lijeka Hulio je 40 mg svaki drugi tjedan s metotreksatom.
English: The usual dose for adults with psoriasis is an initial dose of 80 mg (as two 40 mg injections in one day), followed by 40 mg given every other week starting one week after the initial dose.
Croatian: Uobičajena doza za odrasle bolesnike sa psorijazom je početna doza od 80 mg (u obliku dvije injekcije od 40 mg u jednom danu), nakon čega slijedi 40 mg svaki drugi tjedan, počevši tjedan dana nakon početne doze.
English: Step 6 - Insert needle into site
Croatian: Korak 6 - Postavite brizgalicu na mjesto
English: Musculoskeletal pain
Croatian: • mišićno-koštana bol.
English: o DO NOT use the syringe if the liquid is cloudy, discoloured, or has particles in it.
Croatian: ◦ NEMOJTE upotrebljavati štrcaljku ako je otopina zamućena, promjenjene boje ili sadrži čestice.
English: Adalimumab 40 mg eow N=814 n (%)
Croatian: Adalimumab 40 mg svaki drugi tjedan N=814 n (%)
English: < 0.001c
Croatian: 26,0a
English: If this dose does not work well enough, your child's doctor may increase the dose frequency to 20 mg every week.
Croatian: Ako ta doza nije djelotvorna, liječnik Vašeg djeteta može povećati učestalost doziranja na 20 mg svaki tjedan.
English: • the treatment of moderate to severe, active rheumatoid arthritis in adult patients when the response to disease-modifying anti-rheumatic drugs including methotrexate has been inadequate.
Croatian: • liječenje umjereno teškog do teškog oblika reumatoidnog artritisa u aktivnoj fazi u odraslih bolesnika u kojih prethodnim liječenjem antireumaticima koji modificiraju tijek bolesti,
English: MARKETING AUTHORISATION NUMBER(S) EU/1/18/1319/007
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/18/1319/007
English: Hulio 40 mg solution for injection in pre-filled syringe adalimumab
Croatian: Hulio 40 mg otopina za injekciju u napunjenoj štrcaljki adalimumab
English: Adalimumab 40 mg eow N=108 n (%)
Croatian: Adalimumab 40 mg svaki drugi tjedan N=108 n (%)
English: • any infection (including tuberculosis, blood poisoning, influenza, cellulitis, shingles, ear infections, tooth infections, cold sores, reproductive tract infections, urinary tract infection,
Croatian: • bilo kakve infekcije (uključujući tuberkulozu, otrovanje krvi, gripu, celulitis, herpes zoster,
English: What Hulio is and what it is used for What you need to know before giving your child Hulio How to use Hulio
Croatian: Što morate znati prije nego počnete primjenjivati lijek Hulio Kako primjenjivati lijek Hulio Moguće nuspojave
English: It is important to tell your doctor if you have had or have a serious heart condition (see “Warnings and precautions”).
Croatian: Ako ste bolovali ili bolujete od ozbiljne srčane bolesti, važno je da to kažete liječniku (pogledajte dio „Upozorenja i mjere opreza”).
English: NA NA 4.5% 23.2% a RA study I at 24 weeks, RA study II at 26 weeks , and RA study III at 24 and 52 weeks b 40 mg adalimumab administered every other week c MTX = methotrexate
Croatian: ND ND 4,5% 23,2% a Ispitivanje RA I nakon 24 tjedna, ispitivanje RA II nakon 26 tjedana, ispitivanje RA III nakon
English: How to use Hulio
Croatian: Kako primjenjivati lijek Hulio
English: In monotherapy, some patients who experience a decrease in their response to Hulio 40 mg every other week may benefit from an increase in dosage to 40 mg adalimumab every week or 80 mg every other week.
Croatian: U slučaju monoterapije, u nekih bolesnika u kojih je došlo do slabljenja odgovora na liječenje lijekom Hulio u dozi od 40 mg svaki drugi tjedan možda će biti korisno povećati dozu adalimumaba na 40 mg svaki tjedan ili 80 mg svaki drugi tjedan.
English: Gently squeeze the injection site to create a raised area, and hold that area firmly.
Croatian: Lagano stisnite mjesto ubrizgavanja da biste odigli kožu i čvrsto ga primite.
English: Your child's doctor may also prescribe an initial dose of 80 mg which may be administered one week prior to the start of the usual recommended dose.
Croatian: Liječnik Vašeg djeteta će možda propisati i početnu dozu od 80 mg koja se može primijeniti tjedan dana prije početka primjene uobičajene preporučene doze.
English: Hulio 40 mg/0.8 ml solution for injection
Croatian: NAZIV LIJEKA Hulio 40 mg/0,8 ml otopina za injekciju
English: In patients with Crohn's disease, the loading dose of 80 mg adalimumab on week 0 followed by 40 mg adalimumab on week 2 achieves serum adalimumab trough concentrations of approximately 5.5 μg/ml during the induction period.
Croatian: Tijekom razdoblja indukcije u bolesnika s Crohnovom bolešću nakon udarne doze od 80 mg adalimumaba u nultom tjednu i zatim 40 mg u 2. tjednu postignute su najniže serumske koncentracije adalimumaba od približno 5,5 µg/ml.
English: a HR of adalimumab vs placebo from proportional hazards regression with treatment as factor.
Croatian: Bolesnici koji su izašli iz ispitivanja zbog razloga koji nisu bili neuspjeh liječenja bili su cenzurirani u trenutku izlaska iz ispitivanja. a HR za adalimumab naspram placeba iz regresije proporcionalnih hazarda, uz liječenje kao faktor.
English: • 6 pre-filled syringes (with 6 alcohol pads)
Croatian: • 6 napunjenih štrcaljki (sa 6 jastučića natopljenih alkoholom)
English: Hulio 40 mg solution for injection in pre-filled pen Hulio 40 mg solution for injection in single-use pre-filled pen containing a pre-filled syringe.
Croatian: Hulio 40 mg otopina za injekciju u napunjenoj brizgalici za jednokratnu primjenu koja sadrži napunjenu štrcaljku.
English: DO NOT twist the needle cap.
Croatian: NE zakrećite kapicu igle.
English: Each Hulio vial contains 38.2 mg of sorbitol.
Croatian: Jedna bočica lijeka Hulio sadrži 38,2 mg sorbitola.
English: The recommended Hulio dose is 80 mg at week 0 followed by 40 mg every other week starting at week 1 via subcutaneous injection.
Croatian: Preporučena doza lijeka Hulio je 80 mg u nultom tjednu, nakon koje se primjenjuje doza od 40 mg svaki drugi tjedan, počevši od prvog tjedna, supkutanom injekcijom.
English: Step 5 - Squeeze & hold injection site
Croatian: Korak 5 - Stisnite i držite mjesto ubrizgavanja
English: The recommended dose of Hulio for paediatric patients with uveitis from 2 years of age is based on body weight (Table 5).
Croatian: Preporučena doza lijeka Hulio za pedijatrijske bolesnike s uveitisom u dobi od 2 i više godina određuje se na temelju tjelesne težine (Tablica 5).
English: pJIA I
Croatian: pJIA
English: Check with your healthcare provider for instructions on how to properly dispose of a filled sharps container.
Croatian: Upute o pravilnom odlaganju napunjenog spremnika za zbrinjavanje oštrih predmeta zatražite od svog davatelja zdravstvenih usluga.
English: If this dose does not work well enough, your doctor may increase the dose frequency to 20 mg every week.
Croatian: Ako ta doza nije djelotvorna, liječnik može povećati učestalost doziranja na 20 mg svaki tjedan.
English: • 6 pre-filled pens (with 6 alcohol pads)
Croatian: • 6 napunjenih brizgalica (sa 6 jastučića natopljenih alkoholom)
English: In CD Study I and CD Study II, statistically significant improvement in the disease-specific inflammatory bowel disease questionnaire (IBDQ) total score was achieved at week 4 in patients randomised to adalimumab 80/40 mg and 160/80 mg compared to placebo and was seen at weeks 26 and 56 in CD Study III as well among the adalimumab treatment groups compared to the placebo group.
Croatian: U 4. tjednu ispitivanja CD I i CD II, u bolesnika koji su randomizirani za primanje adalimumaba 80/40 mg i adalimumaba 160/80 mg došlo je do statistički značajnog poboljšanja ukupnog rezultata prema upitniku o upalnoj bolesti crijeva (engl.
English: Children and adolescents from 2 to 17 years of age weighing 10 kg to less than 30 kg: The recommended dose of Hulio is 20 mg every other week.
Croatian: Djeca i adolescenti u dobi od 2 do 17 godina, tjelesne težine od 10 kg do manje od 30 kg: Preporučena doza lijeka Hulio je 20 mg svaki drugi tjedan.
English: Children and adolescents from 6 to 17 years of age weighing 15 kg to less than 30 kg: The recommended dose of Hulio is 20 mg every other week.
Croatian: Djeca i adolescenti u dobi od 6 do 17 godina, tjelesne težine od 15 kg do manje od 30 kg: Preporučena doza lijeka Hulio je 20 mg svaki drugi tjedan.
English: a a a p<0.001, adalimumab vs. placebo
Croatian: −11,5 −56,2a a p<0,001, adalimumab u usporedbi s placebom
English: The third group received 40 mg of adalimumab every other week with placebo injections on alternate weeks.
Croatian: Treća je skupina naizmjenično dobivala 40 mg adalimumaba ili placebo injekcije (jedan tjedan 40 mg adalimumaba, drugi tjedan placebo).
English: Step 10 - Dispose pen & cap Dispose of the used pen and cap in an approved sharps disposal container.
Croatian: Korak 10 - Odložite brizgalicu i kapicu u otpad
English: If these medicines do not work well enough your child will be given Hulio to reduce the signs and symptoms of his/her Crohn's disease.
Croatian: Ako ti lijekovi ne budu dovoljno djelotvorni, Vašem će djetetu u svrhu smanjenja znakova i simptoma Crohnove bolesti biti propisan lijek Hulio.
English: In case there is a need for a more rapid response to therapy, the regimen 160 mg at week 0 (given as four 40 mg injections in one day or as two injections per day for two consecutive days), 80 mg at week 2 (given as two 40 mg injections in one day), can be used with the awareness that the risk for adverse events is higher during induction.
Croatian: U slučaju da postoji potreba za bržim odgovorom na terapiju, terapija se može započeti dozom od 160 mg u nultom tjednu (primijenjenom u obliku četiri injekcije od 40 mg u jednom danu ili dvije injekcije od 40 mg na dan kroz dva uzastopna dana) i 80 mg u drugom tjednu (primijenjenom u obliku dvije injekcije od 40 mg u jednom danu), uz napomenu da je rizik od razvoja nuspojava veći prilikom indukcije.
English: Room spinning sensation (vertigo) and vision disturbances may occur after taking Hulio.
Croatian: Nakon uzimanja lijeka Hulio može se javiti osjećaj da se prostorija vrti (vertigo) te smetnje vida.
English: Hepatitis, reactivation of hepatitis B1), autoimmune hepatitis1)
Croatian: vrlo često povišeni jetreni enzimi manje često kolecistitis i kolelitijaza, steatoza jetre, povišeni bilirubin rijetko hepatitis, reaktivacija hepatitisa B1), autoimuni hepatitis1)
English: The recommended dose of Hulio for adult patients with uveitis is an initial dose of 80 mg, followed by 40 mg given every other week starting one week after the initial dose.
Croatian: Preporučena doza lijeka Hulio u odraslih bolesnika s uveitisom je početna doza od 80 mg, nakon koje slijedi doza od 40 mg svaki drugi tjedan, počevši tjedan dana nakon početne doze.
English: The recommended Hulio induction dose regimen for adult patients with moderate to severe ulcerative colitis is 160 mg at week 0 (given as four 40 mg injections in one day or as two 40 mg injections per day for two consecutive days) and 80 mg at week 2 (given as two 40 mg injections in one day).
Croatian: Preporučena indukcijska doza lijeka Hulio u odraslih bolesnika s umjerenim do teškim ulceroznim kolitisom je 160 mg u nultom tjednu (primijenjena u obliku četiri injekcije od 40 mg u jednom danu ili kao dvije injekcije od 40 mg na dan kroz dva uzastopna dana) i 80 mg u drugom tjednu (primijenjena u obliku dvije injekcije od 40 mg u jednom danu).
English: Hulio 40 mg solution for injection (injection) in pre-filled syringe is supplied as a sterile solution of 40 mg adalimumab dissolved in 0.8 ml clear or slightly opalescent, colourless to pale brownish-yellow solution.
Croatian: Hulio 40 mg otopina za injekciju (injekcija) u napunjenoj brizgalici dolazi kao sterilna otopina s 40 mg adalimumaba otopljenog u 0,8 ml prozirne ili lagano opalescentne, bezbojne do blijedo smećkasto-žute otopine.
English: Children and adolescents from 4 to 17 years of age weighing 30 kg or more:
Croatian: Djeca i adolescenti u dobi od 4 do 17 godina, tjelesne težine 30 kg ili više:
English: Table 20: Paediatric Plaque Psoriasis Efficacy Results at 16 weeks MTXa N=37
Croatian: Tablica 20: Rezultati djelotvornosti u pedijatrijskih bolesnika s plak psorijazom u 16. tjednu
English: Some patients who experience decrease in their response to Hulio 40 mg every other week may benefit from an increase in dosage to 40 mg Hulio every week or 80 mg every other week.
Croatian: U nekih bolesnika u kojih dođe do slabljenja odgovora na terapiju lijekom Hulio u dozi od 40 mg svaki drugi tjedan možda će biti korisno povećati doziranje na 40 mg lijeka Hulio svaki tjedan ili 80 mg svaki drugi tjedan.
English: Step 7 - Attach syringe to vial adapter and push plunger rod Hold the syringe on the graduated area and remove it from the packaging.
Croatian: Korak 5 - Pričvrstite nastavak za bočicu na bočicu Uklonite pokrov s pakiranja nastavka za bočicu, ali NEMOJTE vaditi nastavak iz pakiranja.
English: • 1 alcohol swab
Croatian: • 1 jastučić natopljen alkoholom
English: Sarcoidosis1), vasculitis
Croatian: manje često sarkoidoza1), vaskulitis rijetko anafilaksa1)
English: The usual Hulio dose for adults with ulcerative colitis is 160 mg initially (given as four 40 mg injections in one day, or as two 40 mg injections per day for two consecutive days) followed by 80 mg (as two 40 mg injections in one day) two weeks later, and then 40 mg every other week.
Croatian: Uobičajena početna doza lijeka Hulio za odrasle bolesnike s ulceroznim kolitisom je 160 mg (u obliku četiri injekcije od 40 mg u jednom danu ili dvije injekcije od 40 mg na dan tijekom dva uzastopna dana), nakon čega poslije dva tjedna slijedi doza od 80 mg (u obliku dvije injekcije od 40 mg u jednom danu), a zatim 40 mg svaki drugi tjedan.
English: 1 pre-filled pen
Croatian: • 1 napunjena brizgalica
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON - VIAL SINGLE UNIT PACK
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKA KUTIJA - JEDNOSTRUKO PAKIRANJE BOČICA
English: If this dose does not work well enough, your child's doctor may increase the dosage to 40 mg every week or 80 mg every other week.
Croatian: Ako ta doza nije djelotvorna, liječnik Vašeg djeteta može povećati dozu na 40 mg svaki tjedan ili 80 mg svaki drugi tjedan.
English: The recommended Hulio dose regimen for adult patients with hidradenitis suppurativa (HS) is 160 mg initially at Day 1 (given as four 40 mg injections in one day or as two 40 mg injections per day for two consecutive days), followed by 80 mg two weeks later at Day 15 (given as two 40 mg injections in one day).
Croatian: Preporučen režim doziranja lijeka Hulio za odrasle bolesnike s gnojnim hidradenitisom je početna doza od 160 mg prvoga dana (primijenjena u obliku četiri injekcije od 40 mg u jednom danu ili dvije injekcije od 40 mg na dan tijekom dva uzastopna dana), nakon koje slijedi doza od 80 mg dva tjedna kasnije, 15. dana (primijenjena u obliku dvije injekcije od 40 mg u jednom danu).
English: Hulio therapy should not be continued in patients failing to respond within this time period.
Croatian: U bolesnika u kojih u ovom razdoblju ne bude odgovora, liječenje lijekom Hulio ne treba nastaviti.
English: • Tell your child's doctor if you have a history of recurrent infections or other conditions that increase the risk of infections.
Croatian: • Ako je Vaše dijete ranije bolovalo od infekcija koje su se ponavljale ili drugih stanja koja povisuju rizik od infekcije, recite to liječniku svog djeteta.
English: Week 52 62.6% 54.4%
Croatian: 52. tjedan 62,6% 54,4% 72,8% 0,013
English: The usual dose regimen is 80 mg initially (as two 40 mg injections in one day), followed by 40 mg two weeks later.
Croatian: Uobičajena početna doza je 80 mg (u obliku dvije injekcije od 40 mg u jednom danu), nakon čega poslije dva tjedna slijedi doza od 40 mg.
English: Patients had serum samples tested for autoantibodies at multiple time points in rheumatoid arthritis studies I − V. In these trials, 11.9% of patients treated with adalimumab and 8.1% of placebo and active control − treated patients that had negative baseline anti-nuclear antibody titres reported positive titres at week 24.
Croatian: U tim ispitivanjima, u 11,9% bolesnika liječenih adalimumabom i 8,1% bolesnika koji su primali placebo i aktivni kontrolni lijek i koji su prije početka liječenja imali negativan titar antinuklearnih protutijela zabilježen je pozitivan titar nakon 24 tjedna primjene lijeka.
English: - If your child gets any side effects, talk to your child's doctor or pharmacist.
Croatian: - Ako primijetite bilo koju nuspojavu kod Vašeg djeteta, potrebno je obavijestiti liječnika ili ljekarnika Vašeg djeteta.
English: Children and adolescents from 4 to 17 years of age weighing 15 kg to less than 30 kg: The recommended dose of Hulio is an initial dose of 20 mg, followed by 20 mg one week later, Thereafter the usual dose is 20 mg every other week.
Croatian: Djeca i adolescenti u dobi od 4 do 17 godina, tjelesne težine od 15 kg do manje od 30 kg: Preporučena doza lijeka Hulio je početna doza od 20 mg, a zatim 20 mg nakon tjedan dana.
English: In patients with ulcerative colitis, a loading dose of 160 mg adalimumab on week 0 followed by 80 mg adalimumab on week 2 achieves serum adalimumab trough concentrations of approximately 12 μg/ml during the induction period.
Croatian: Tijekom razdoblja indukcije u bolesnika s ulceroznim kolitisom, nakon udarne doze od 160 mg adalimumaba u nultom tjednu i zatim 80 mg u 2. tjednu postignute su najniže serumske koncentracije adalimumaba od oko 12 µg/ml.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/18/1319/004 1 pack
Croatian: 12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/18/1319/008 1 bočica
English: The pre-filled syringes should be stored in the fridge (between 2°C to 8°C).
Croatian: Napunjenu brizgalicu čuvajte u hladnjaku (na temperaturi od 2 °C do 8 °C).
English: It is recommended that your child uses an antiseptic wash daily on the affected areas during treatment with Hulio.
Croatian: Tijekom liječenja lijekom Hulio preporučuje se da dijete svakodnevno ispire zahvaćena područja antiseptičkom tekućinom.
English: Children or adolescents from 6 to 17 years weighing 40 kg or more:
Croatian: Djeca ili adolescenti u dobi od 6 do 17 godina, tjelesne težine 40 kg ili više:
English: Steroid-free remission for ≥ 90 days a
Croatian: Bolsnici u remisiji bez primjene steroida ≥ 90 danaa
English: If you take Hulio the risk of getting lymphoma, leukaemia, or other cancers may increase.
Croatian: Rizik obolijevanja od limfoma, leukemije ili drugih tumora može se povećati ako primijenjujete lijek Hulio.
English: Adalimumab 40 mg every other week was assessed in 393 patients in two randomised, 24 week double-blind, placebo-controlled studies in patients with active ankylosing spondylitis (mean baseline score of disease activity [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)] was 6.3 in all groups) who have had an inadequate response to conventional therapy.
Croatian: U dva dvostruko slijepa, randomizirana, placebom kontrolirana ispitivanja kroz 24 tjedna ispitivano je djelovanje adalimumaba u dozi od 40 mg svaka dva tjedna u 393 bolesnika s aktivnim ankilozantnim spondilitisom (srednja početna vrijednost aktivnosti bolesti [engl.
English: Lymphoma**, solid organ neoplasm (including breast cancer, lung neoplasm and thyroid neoplasm), melanoma**
Croatian: Često rak kože, isključujući melanom (uključujući bazocelularni karcinom i karcinom skvamoznih stanica), benigne neoplazme manje često limfom**, novotvorine na solidnim organima (uključujući rak dojke, novotvorine na plućima i štitnjači), melanom**
English: The usual dose regimen for hidradenitis suppurativa is an initial dose of 160 mg (as four 40 mg injections in one day or two 40 mg injections per day for two consecutive days), followed by an 80 mg dose (as two 40 mg injections on the same day) two weeks later.
Croatian: Uobičajen režim doziranja za gnojni hidradenitis je početna doza od 160 mg (u obliku četiri injekcije od 40 mg u jednom danu ili dvije injekcije od 40 mg na dan, tijekom dva uzastopna dana), nakon koje se dva tjedna kasnije primjenjuje doza od 80 mg (u obliku dvije injekcije od 40 mg u istom danu).
English: Gently set the connected vial and adapter down on a flat work surface.
Croatian: Pažljivo odložite bočicu s pričvršćenim nastavkom na čistu radnu površinu.
English: Children and adolescents from 6 to 17 years of age weighing 30 kg or more: The recommended dose of Hulio is 40 mg every other week.
Croatian: Djeca i adolescenti u dobi od 6 do 17 godina, tjelesne težine 30 kg ili više: Preporučena doza lijeka Hulio je 40 mg svaki drugi tjedan.
English: Methotrexate should be continued during treatment with Hulio.
Croatian: Za vrijeme liječenja lijekom Hulio treba nastaviti primjenu metotreksata.
English: Hulio is administered by injection under the skin (subcutaneous use).
Croatian: Hulio se primjenjuje potkožnom injekcijom (supkutana injekcija).