FrancophonIA/ELRC3.0 huggingface dataset:
English: Cmax and to a lesser extent AUC increase disproportionately at doses above 40 mg.
Slovenian: Cmax in v manjši meri tudi AUC se pri odmerkih nad 40 mg povečujeta nesorazmerno.
English: The incidence of adverse reactions was not dose related and showed no correlation with gender, age or race of the patients.
Slovenian: Incidenca neželenih učinkov ni bila povezana z odmerkom in ni korelirala s spolom, starostjo ali raso bolnikov.
English: Concomitant use requiring caution
Slovenian: Sočasna uporaba, ki zahteva previdnost
English: CV mortality and all cause mortality were numerically higher with the combination.
Slovenian: Srčnožilna umrljivost in umrljivost zaradi vseh vzrokov sta bili s kombinacijo številsko večji.
English: Absorption of telmisartan is rapid although the amount absorbed varies.
Slovenian: Absorpcija telmisartana je hitra, a absorbirana količina je variabilna.
English: When considering raising the dose, it must be borne in mind that the maximum antihypertensive effect is generally attained four to eight weeks after the start of treatment (see section 5.1).
Slovenian: Pri razmisleku o povečanju odmerka je treba upoštevati, da je največji antihipertenzivni učinek praviloma doseže od štiri do osem tednov po začetku zdravljenja (glejte poglavje 5.1).
English: - Raised aldosterone levels (water and salt retention in the body along with imbalance of various blood minerals).
Slovenian: - Zvišano koncentracijo aldosterona (povzroči zastajanje vode in soli v telesu ter neravnovesje različnih mineralov v krvi).
English: (It is also better to avoid Telmisartan Actavis in early pregnancy - see pregnancy section.)
Slovenian: (Zdravilu Telmisartan Actavis se je tudi v zgodnji nosečnosti bolje izogniti - glejte poglavje o nosečnosti.)
English: In this respect data concerning diastolic blood pressure (DBP) are inconsistent.
Slovenian: Podatki za diastolični krvni tlak (DKT) glede tega niso konsistentni.
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded.
Slovenian: Epidemiološke ugotovitve o tveganju teratogenih učinkov po izpostavljenosti zaviralcem ACE v prvem trimesečju nosečnosti niso dokončne, vendar majhnega povečanja tveganja ni mogoče izključiti.
English: The mean absolute bioavailability for telmisartan is about 50%.
Slovenian: Povprečna absolutna biološka uporabnost telmisartana je približno 50 %.
English: (See section 5.3).
Slovenian: in 5.1).
English: The maximum reduction in blood pressure is generally attained 4 to 8 weeks after the start of treatment and is sustained during long-term therapy.
Slovenian: Največje znižanje krvnega tlaka je na splošno doseženo v 4 do 8 tednih po začetku zdravljenja in se med dolgotrajnim zdravljenjem ohrani.
English: It is important that you take Telmisartan Actavis every day until your doctor tells you otherwise.
Slovenian: Pomembno je, da ta vzamete zdravilo Telmisartan Actavis vsak dan, dokler vaš zdravnik ne določi drugače.
English: This applies especially to the medicines listed below taken at the same time with Telmisartan Actavis
Slovenian: To še posebej velja za spodaj našteta zdravila, uporabljena hkrati z zdravilom Telmisartan Actavis.
English: The pharmacokinetics of telmisartan do not differ between the elderly and those younger than 65 years.
Slovenian: Starejši Farmakokinetika telmisartana se pri starejših ne razlikuje od tiste pri mlajših od 65 let.
English: Serum electrolytes and creatinine should be monitored frequently.
Slovenian: Pogosto je treba kontrolirati elektrolite in kreatinin v serumu.
English: Therefore it is not expected to potentiate bradykininmediated adverse effects.
Slovenian: Zato ni pričakovati, da bi stopnjeval z bradikininom posredovane neželene učinke.
English: The contribution of the medicinal product's diuretic and natriuretic effect to its hypotensive activity has still to be defined.
Slovenian: Prispevek diuretičnega in natriuretičnega učinka tega zdravila k njegovemu antihipertenzivnemu delovanju bo treba še opredeliti.
English: The main risk factors for hyperkalaemia to be considered are: - Diabetes mellitus, renal impairment, age (> 70 years)
Slovenian: Glavni dejavniki tveganja za hiperkaliemijo, ki jih je treba upoštevati, so: - sladkorna bolezen, okvara ledvic, starost (> 70 let)
English: After oral (and intravenous) administration telmisartan is nearly exclusively excreted with the faeces, mainly as unchanged compound.
Slovenian: Po peroralni (in intravenski) uporabi se telmisartan izloči skoraj izključno v blatu, predvsem kot nespremenjena spojina.
English: The functional role of these receptors is not known, nor is the effect of their possible overstimulation by angiotensin II, whose levels are increased by telmisartan.
Slovenian: Funkcionalna vloga teh receptorjev ni znana, prav tako ni znan učinek njihove morebitne čezmerne stimulacije z angiotenzinom II, katerega koncentracijo telmisartan poveča.
English: Do not use this medicine after the expiry date which is stated on the carton, bottle or blister after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli, steklenički ali pretisnem omotu poleg oznake "EXP".
English: The maximum plasma concentration (Cmax) and, to a smaller extent, the area under the plasma concentration-time curve (AUC) increase disproportionately with dose.
Slovenian: Največja koncentracija v plazmi (Cmax) in v manjši meri površina pod krivuljo plazemske koncentracije po času (AUC) se povečujeta nesorazmerno odmerku.
English: Management depends on the time since ingestion and the severity of the symptoms.
Slovenian: Obvladovanje je odvisno od časa, ki je pretekel od zaužitja, in od izrazitosti simptomov.
English: Your doctor will normally advise you to stop taking Telmisartan Actavis before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Telmisartan Actavis.
Slovenian: Zdravnik vam bo praviloma svetoval, da nehajte jemati zdravilo Telmisartan Actavis, preden zanosite ali čim ugotovite, da ste noseči, in vam bo namesto zdravila Telmisartan Actavis predpisal neko drugo zdravilo.
English: Dual blockade of the renin-angiotensin-aldosterone system (RAAS):
Slovenian: Dvojna blokada sistema renin-angiotenzin-aldosteron (RAAS)
English: Telmisartan is largely bound to plasma protein (> 99.5%), mainly albumin and alpha-1 acid glycoprotein.
Slovenian: Porazdelitev Telmisartan je v veliki meri vezan na beljakovine v plazmi (> 99,5 %), predvsem albumin in alfa-1
English: Based on their pharmacological properties it can be expected that the following medicinal products may potentiate the hypotensive effects of all antihypertensives including telmisartan: Baclofen, amifostine.
Slovenian: Na podlagi njihovih farmakoloških lastnosti je mogoče pričakovati, da lahko naslednja zdravila povečajo hipotenzivne učinke vseh antihipertenzivov, vključno s telmisartanom: baklofen, amifostin.
English: However, it is not known whether telmisartan was the cause.
Slovenian: vendar ni znano ali je vzrok telmisartan.
English: - Heart trouble.
Slovenian: - Težave s srcem.
English: Telmisartan Actavis tablets are used to treat essential hypertension (high blood pressure) in adults.
Slovenian: Tablete Telmisartan Actavis se uporabljajo za zdravljenje esencialne hipertenzije (visokega krvnega tlaka) pri odraslih.
English: A combination with ACE inhibitors or NSAIDs, for example, presents a lesser risk provided that precautions for use are strictly followed.
Slovenian: Kombinacija z zaviralci ACE ali NSAID pa na primer pomeni manjše tveganje, če so strogo upoštevani vsi previdnostni ukrepi.
English: Activated charcoal may be useful in the treatment of overdosage.
Slovenian: Pri zdravljenju prevelikega odmerjanja lahko koristi aktivno oglje.
English: Blood creatinine increased
Slovenian: zvišanje kreatinina v krvi
English: When telmisartan is taken with food, the reduction in the area under the plasma concentration-time curve (AUC0-∞) of telmisartan varies from approximately 6% (40 mg dose) to approximately 19% (160 mg dose).
Slovenian: Če je telmisartan uporabljen s hrano, sega zmanjšanje površine pod krivuljo koncentracije v plazmi po času (AUC0-∞) telmisartana od približno 6 % (40-mg odmerek) do približno 19 % (160 mg odmerek).
English: The adverse reactions listed below have been accumulated from controlled clinical trials in patients treated for hypertension and from post-marketing reports.
Slovenian: Spodaj našteti neželeni učinki so zajeti iz kontroliranih kliničnih preskušanj bolnikov, zdravljenih zaradi hipertenzije, in iz postmarketinških poročil.
English: Very rare side effects (may affect up to 1 in 10,000 people): Progressive scarring of lung tissue (interstitial lung disease)**.
Slovenian: Zelo redki neželeni učinki (pojavijo se lahko pri največ 1 od 10.000 bolnikov): Progresivno brazgotinjenje pljučnega tkiva (intersticijska pljučna bolezen)**.
English: Tablet container: 30 and 250 tablets.
Slovenian: Vsebniki za tablete: 30 in 250 tablet.
English: - Combination with one or more other medicinal products that affect the renin-angiotensinaldosterone system and/or potassium supplements.
Slovenian: - kombinacija z enim ali več drugimi zdravili, ki vplivajo na sistem renin-angiotenzin-aldosteron, in/ali dodatki kalija.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 30.09.2010
Slovenian: Datum prve odobritve: 30.09.2010 Datum zadnjega podaljšanja:
English: The inhibitory effect is maintained over 24 hours and still measurable up to 48 hours.
Slovenian: Zavrtje se ohrani 24 ur in je še merljivo po 48 urah.
English: The antihypertensive effect persists constantly over 24 hours after dosing and includes the last 4 hours before the next dose as shown by ambulatory blood pressure measurements.
Slovenian: Antihipertenzivni učinek ostaja stalen v 24 urah po uporabi, vključno z zadnjimi 4 urami pred naslednjim odmerkom, kot je bilo dokazano s kontinuiranimi meritvami krvnega tlaka.
English: You can take Telmisartan Actavis with or without food.
Slovenian: Zdravilo Telmisartan Actavis lahko vzamete s hrano ali brez nje.
English: If hypotension occurs, the patient should be placed in a supine position, with salt and volume replacement given quickly.
Slovenian: Če se pojavi hipotenzija, je treba bolnika poleči in mu hitro nadomestiti sol in volumen.
English: The incidence of the primary endpoint was similar in the telmisartan (16.7%) and ramipril (16.5%) groups.
Slovenian: Incidenca primarnega opazovanega dogodka je bila v skupini s telmisartanom (16,7 %) podobna kot v skupini z ramiprilom (16,5 %).
English: Hypertension Treatment of essential hypertension in adults.
Slovenian: Zdravljenje esencialne hipertenzije pri odraslih.
English: By 3 hours after administration plasma concentrations are similar whether telmisartan is taken fasting or with food.
Slovenian: Do preteka 3 ur po uporabi je koncentracija v plazmi podobna, ne glede na to, ali je telmisartan uporabljen na prazen želodec ali s hrano.
English: If any of the above applies to you, tell your doctor or pharmacist before taking Telmisartan Actavis.
Slovenian: Če karkoli od naštetega velja za vas, morate to povedati zdravniku ali farmacevtu, preden vzamete zdravilo Telmisartan Actavis.
English: In patients with liver problems the usual dose should not exceed 40 mg once daily.
Slovenian: Pri bolnikih, ki imajo težave z jetri, običajni odmerek ne sme preseči 40 mg enkrat na dan.
English: PHARMACEUTICAL FORM Tablet
Slovenian: FARMACEVTSKA OBLIKA tableta
English: Possible side effects of telmisartan:
Slovenian: Možni neželeni učinki telmisartana so:
English: Therefore the use of a combination of telmisartan and ramipril is not recommended in this population.
Slovenian: Zato v tej populaciji ni priporočljivo uporabljati kombinacije telmisartana in ramiprila.
English: In patients with kidney problems a lower starting dose of 20 mg is recommended.
Slovenian: Pri bolnikih, ki imajo težave z ledvicami, je priporočljiv manjši začetni odmerek 20 mg.
English: Before considering the concomitant use of medicinal products that affect the renin-angiotensinaldosterone system, the benefit risk ratio should be evaluated.
Slovenian: Pred odločitvijo za sočasno uporabo zdravil, ki vplivajo na sistem renin-angiotenzin-aldosteron, je treba oceniti razmerje med koristjo in tveganjem.
English: Telmisartan is characterised by biexponential decay pharmacokinetics with a terminal elimination half-life of > 20 hours.
Slovenian: Telmisartan ima bieksponentno farmakokinetiko upadanja s terminalnim eliminacijskim razpolovnim časom > 20 ur.
English: In both species, increased plasma renin activity and hypertrophy/hyperplasia of the renal juxtaglomerular cells were observed.
Slovenian: Pri obeh živalskih vrstah so opažali povečano aktivnost renina v plazmi ter hipertrofijo/hiperplazijo jukstaglomerularnih ledvičnih celic.
English: See also information under the heading “Do not take Telmisartan Actavis”.
Slovenian: Glejte tudi informacije pod naslovom “Ne jemljite zdravila Telmisartan Actavis''.
English: - If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take Telmisartan Actavis” and “Warnings and precautions”).
Slovenian: - Če jemljete zaviralec ACE ali aliskiren (glejte tudi informacije pod naslovoma "Ne jemljite zdravila Telmisartan Actavis" in "Opozorila in previdnostni ukrepi").
English: - if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Slovenian: - če imate sladkorno bolezen ali okvaro delovanja ledvic in se zdravite z zdravilom za znižanje krvnega tlaka, ki vsebuje aliskiren.
English: Al/Al blisters:
Slovenian: Al/Al pretisni omot:
English: If you take more Telmisartan Actavis than you should It is important to keep to the dose as prescribed by your doctor.
Slovenian: Če ste vzeli večji odmerek zdravila Telmisartan Actavis, kot bi smeli Pomembno je, da uporabljate odmerek, ki vam ga je predpisal zdravnik.
English: If concomitant use is indicated because of documented hypokalaemia, they should be used with caution and with frequent monitoring of serum potassium.
Slovenian: Če je sočasna uporaba zaradi dokazane hipokaliemije indicirana, jih je treba uporabljati previdno in pogosto kontrolirati kalij v serumu.
English: HDPE tablet container:
Slovenian: HDPE vsebnik:
English: The listing also takes into account serious adverse reactions and adverse reactions leading to discontinuation reported in three clinical long-term studies including 21642 patients treated with telmisartan for the reduction of cardiovascular morbidity for up to six years.
Slovenian: Seznam upošteva tudi resne neželene učinke in neželene učinke, ki so povzročili prekinitev zdravljenja, zabeležene v treh dolgoročnih kliničnih študijah, ki so zajele 21642 bolnikov, do šest let zdravljenih s telmisartanom za zmanjšanje srčnožilne obolevnosti.
English: The most common symptoms of telmisartan overdose are low blood pressure (hypotension) and fast heart beat (tachycardia).
Slovenian: Najpogostejši simptomi prevelikega odmerjanja telmisartana so nizek krvni tlak (hipotenzija) in hitro bitje srca (tahikardija).
English: Telmisartan Actavis is also used to reduce cardiovascular events (i.e. heart attack or stroke) in adults who are at risk because they have a reduced or blocked blood supply to the heart or legs, or have had a stroke or have high risk diabetes.
Slovenian: Zdravilo Telmisartan Actavis se uporablja tudi za zmanjševanje srčnožilnih dogodkov (npr. srčnega napada ali možganske kapi) pri odraslih s tveganjem zaradi zmanjšane ali blokirane oskrbe srca ali nog s krvjo, ali pri odraslih, ki so doživeli možgansko kap ali imajo sladkorno bolezen z velikim tveganjem.
English: When initiating telmisartan therapy for the reduction of cardiovascular morbidity, close monitoring of blood pressure is recommended, and if appropriate adjustment of medications that lower blood pressure may be necessary.
Slovenian: Ob uvedbi telmisartana za zmanjšanje srčnožilne obolevnosti je priporočljivo natančno kontrolirati krvni tlak; potrebna je lahko prilagoditev zdravil za znižanje krvnega tlaka, če je ustrezno.
English: In patients with hypertension telmisartan reduces both systolic and diastolic blood pressure without affecting pulse rate.
Slovenian: Bolnikom s hipertenzijo telmisartan zniža sistolični in diastolični krvni tlak, ne da bi vplival na srčno frekvenco.
English: Furthermore, orthostatic hypotension may be aggravated by alcohol, barbiturates, narcotics or antidepressants.
Slovenian: Poleg tega lahko ortostatsko hipotenzijo poslabšajo alkohol, barbiturati, narkotiki ali antidepresivi.
English: Adverse reactions have been ranked under headings of frequency using the following convention: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000).
Slovenian: Neželeni učinki so razvrščeni po oznakah pogostnosti upoštevaje naslednji dogovor: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000
English: There is limited information available with regard to overdose in humans.
Slovenian: Informacij o prevelikem odmerjanju pri človeku je malo.
English: Suggested measures include induction of emesis and / or gastric lavage.
Slovenian: Predlagani ukrepi vključujejo sprožitev bruhanja in/ali izpiranje želodca.
English: If you have the impression that the effect of Telmisartan Actavis is too strong or too weak, talk to your doctor or pharmacist.
Slovenian: Če menite, da je učinek zdravila Telmisartan Actavis premočan ali prešibak se o tem pogovorite z zdravnikom ali s farmacevtom.
English: Therefore, the use of telmisartan is not recommended.
Slovenian: Zato uporaba telmisartana ni priporočljiva.
English: The use of Telmisartan Actavis in children and adolescents up to the age of 18 years is not recommended.
Slovenian: Otroci in mladostniki Uporaba zdravila Telmisartan Actavis pri otrocih in mladostnikih do 18 leta starosti ni priporočljiva.
English: Angiotensin II receptor antagonists should not be initiated during pregnancy.
Slovenian: Antagonistov receptorjev angiotenzina II se ne sme uvesti med nosečnostjo.
English: In some of the investigated patients the doses used were higher than those recommended in the treatment of hypertension in the adult population, reaching a daily dose comparable to160 mg, which was tested in adults.
Slovenian: Pri nekaterih bolnikih so uporabili odmerke, ki so bili večji od priporočenih odmerkov za zdravljenje hipertenzije pri odrasli populaciji, in sicer do dnevnega odmerka, primerljivega z odmerkom po 160
English: The use of medicinal products that affect the renin-angiotensin-aldosterone system may cause hyperkalaemia.
Slovenian: Zdravila, ki vplivajo na sistem renin-angiotenzin-aldosteron, lahko povzročijo hiperkaliemijo.
English: Upon abrupt cessation of treatment with telmisartan, blood pressure gradually returns to pre-treatment values over a period of several days without evidence of rebound hypertension.
Slovenian: Po nenadnem prenehanju zdravljenja s telmisartanom se krvni tlak v nekaj dneh postopoma vrne na vrednosti pred zdravljenjem, brez znakov preobratne hipertenzije.
English: Whilst there is no controlled epidemiological data on the risk with angiotensin II receptor antagonists, similar risks may exist for this class of drugs.
Slovenian: O tveganju z antagonisti receptorjev angiotenzina II ni kontroliranih epidemioloških podatkov, vendar lahko s to skupino zdravil obstajajo podobna tveganja.
English: There is an apparent trend to a dose relationship to a time to recovery of baseline systolic blood pressure (SBP).
Slovenian: Obstaja opazen trend povezanosti z odmerkom, kar zadeva čas do ponovnega doseganja izhodiščnega sistoličnega krvnega tlaka (SKT).
English: In patients with mild to moderate and severe renal impairment, doubling of plasma concentrations was observed.
Slovenian: Pri bolnikih z blago do zmerno in hudo okvaro ledvic so ugotovili podvojitev koncentracije v plazmi.
English: As with any antihypertensive agent, excessive reduction of blood pressure in patients with ischaemic cardiopathy or ischaemic cardiovascular disease could result in a myocardial infarction or stroke.
Slovenian: Kot velja za vsa antihipertenzivna zdravila, lahko čezmerno znižanje krvnega tlaka pri bolnikih z ishemično kardiopatijo ali ishemično srčnožilno boleznijo izzove miokardni infarkt ali možgansko kap.
English: Telmisartan selectively binds the AT1 receptor.
Slovenian: Telmisartan se selektivno veže na receptorje AT1.
English: The safety and efficacy of telmisartan in children and adolescents aged below 18 years have not been established.
Slovenian: Varnost in učinkovitost zdravila Telmisartan Actavis pri otrocih in mladostnikih, mlajših od 18 let, še nista bili dokazani.
English: ‘Essential' means that the high blood pressure is not caused by any other condition.
Slovenian: "Esencialna" pomeni, da visok krvni tlak ni posledica kakšne druge bolezni.
English: Al/Al blisters: Pack sizes: 14, 28, 30, 56, 84, 90, 98 or 100 tablets.
Slovenian: Al/Al pretisni omoti: 14, 28, 30, 56, 84, 90, 98 ali 100 tablet.
English: Total plasma clearance (Cltot) is high (approximately 1,000 ml/min) compared with hepatic blood flow (about 1,500 ml/min).
Slovenian: (Cltot) je v primerjavi z jetrnim pretokom krvi (približno 1.500 ml/min) velik (približno 1.000 ml/min).
English: Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system.
Slovenian: Primarni aldosteronizem Bolniki s primarnim aldosteronizmom se praviloma ne odzovejo na antihipertenzivna zdravila, ki zavirajo sistem renin-angiotenzin.
English: There was no evidence of mutagenicity and relevant clastogenic activity in in vitro studies and no evidence of carcinogenicity in rats and mice.
Slovenian: V študijah in vitro niso ugotovili mutagenosti ali pomembnega klastogenega delovanja in tudi ne kancerogenosti pri podganah in miših.
English: Telmisartan does not inhibit human plasma renin or block ion channels.
Slovenian: Ne zavira pa humanega renina v plazmi in tudi ne blokira ionskih kanalčkov.
English: Talk to your doctor before taking Telmisartan Actavis: - if you are taking digoxin.
Slovenian: Posvetujte se z zdravnikom, preden boste vzeli zdravilo Telmisartan Actavis: - če jemljete digoksin
English: The observed increased occurrence rate of sepsis associated with the use of telmisartan may be either a chance finding or related to a mechanism not currently known.
Slovenian: Opaženo večje pojavljanje sepse v povezavi z uporabo telmisartana je lahko bodisi naključno bodisi povezano z mehanizmom, ki trenutno ni poznan.
English: You should consult with your doctor if you need to adjust the dose of your other medicine while taking Telmisartan Actavis.
Slovenian: Z zdravnikom se morate posvetovati, ali je treba med jemanjem zdravila Telmisartan Actavis prilagoditi odmerek vašega drugega zdravila.
English: The all-cause mortality rate was 11.6 % and 11.8 % among telmisartan and ramipril treated patients, respectively.
Slovenian: Delež umrljivosti zaradi vseh vzrokov je bil v skupini s telmisartanom 11,6 % in v skupini z ramiprilom 11,8 %.
English: In human, an 80 mg dose of telmisartan almost completely inhibits the angiotensin II evoked blood pressure increase.
Slovenian: Pri človeku odmerek 80 mg telmisartana skoraj popolnoma zavre zvišanje krvnega tlaka, izzvano z angiotenzinom II.
English: What Telmisartan Actavis is and what it is used for
Slovenian: Kaj je zdravilo Telmisartan Actavis in za kaj ga uporabljamo
English: When Telmisartan Actavis is used in patients with impaired renal function, periodic monitoring of potassium and creatinine serum levels is recommended.
Slovenian: Med uporabo zdravila Telmisartan Actavis pri bolnikih z okvarjenim delovanjem ledvic so priporočljive redne kontrole kalija in kreatinina v serumu.