FrancophonIA/ELRC3.0 huggingface dataset:
English: Potassium sparing diuretics, potassium supplements or potassium-containing salt substitutes Although serum potassium usually remains within normal limits, hyperkalaemia may occur in some patients treated with cilazapril.
Slovenian: Diuretiki, ki varčujejo s kalijem, dodatki kalija ali nadomestki soli, ki vsebujejo kalij Čeprav serumske koncentracije kalija ponavadi ostanejo v normalnih območjih, lahko pri nekaterih bolnikih, zdravljenih s cilazaprilom, pride do hiperkaliemije.
English: Second and third trimesters of pregnancy (see section 4.4. and 4.6)”
Slovenian: Drugo in tretje trimesečje nosečnosti (glejte poglavji 4.4 in 4.6)“
English: Hypersensitivity/angioedema
Slovenian: Preobčutljivost/angioedem
English: When pregnancy is diagnosed, treatment with ACE inhibitors should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z zaviralci ACE takoj prekiniti in, če je primerno, začeti alternativno zdravljenje (glejte poglavji 4.3 in 4.6).
English: Cilazapril must be stopped before the start of desensitization therapy, and should not be replaced by a β- blocker.
Slovenian: Pred začetkom desenzibilizacijskega zdravljenja je treba cilazapril nehati uporabljati in se ga ne sme nadomestiti z blokatorjem ß.
English: Symptoms of hypotension may include syncope, weakness, dizziness and visual impairment.
Slovenian: Med simptomi hipotenzije so lahko sinkopa, šibkost, omotica in okvara vida.
English: Rarely, neutropenia and agranulocytosis have been associated with ACE inhibitors, especially in patients with renal failure or collagen vascular disease, and those receiving immunosuppressive therapy.
Slovenian: Redko sta bili z zaviralci ACE povezani nevtropenija in agranulocitoza, zlasti pri bolnikih z odpovedjo ledvic ali kolagensko žilno boleznijo ter pri bolnikih, ki so dobivali imunosupresivno zdravljenje.
English: Use of cilazapril with lithium is not recommended, but if the combination proves necessary, careful monitoring of serum lithium levels should be performed.
Slovenian: Uporaba cilazaprila z litijem ni priporočljiva, če pa je sočasna uporaba nujno potrebna, je treba serumske koncentracije litija skrbno spremljati.
English: Hypotension in this setting can be corrected with volume expansion.
Slovenian: Hipotenzijo je v teh okoliščinah mogoče odpraviti z ekspanzijo volumna.
English: It was also recommended by the CHMP that in patients with liver cirrhosis (but without ascites), cilazapril should be initiated at a lower dose since significant hypotension could occur, and in patients with ascites, cilazapril should not be recommended.
Slovenian: CHMP je tudi priporočil, da je treba pri bolnikih s cirozo jeter (vendar brez ascitesa) začeti z dajanjem cilazaprila v manjšem odmerku, saj lahko pride do hude hipotenzije, pri bolnikih z ascitesom pa cilazapril ni priporočljiv.
English: Vital signs, serum electrolytes and creatinine concentrations should be monitored continuously.
Slovenian: Neprekinjeno je treba kontrolirati vitalne znake ter koncentracijo elektrolitov in kreatinina v serumu.
English: The effect is usually not significant in patients with normal renal function.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic ta učinek ponavadi ni bistven.
English: - if you have kidney problems or have a problem with the blood supply to your kidneys called renal artery stenosis.
Slovenian: - če imate težave z ledvicami ali motnjo prekrvitve ledvic, ki jo imenujemo stenoza ledvične arterije.
English: Concomitant use of thiazide diuretics may increase the risk of lithium toxicity and enhance the already increased risk of lithium toxicity with ACE inhibitors.
Slovenian: Sočasna uporaba tiazidnih diuretikov lahko zveča tveganje za toksične učinke litija in še dodatno poveča že povečano tveganje za toksične učinke litija pri uporabi zaviralev ACE.
English: The maximum daily dose for these patients is 5.0 mg.
Slovenian: Največji dnevni odmerek za te bolnike je 5,0 mg.
English: Non-steroidal anti-inflammatory medicinal products (NSAIDs) including aspirin  3 g/day When ACE inhibitors are administered simultaneously with non-steroidal anti-inflammatory drugs (i.e. acetylsalicylic acid at anti-inflammatory dosage regimens, COX-2 inhibitors and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Slovenian: Nesteroidna protivnetna zdravila (NSAID), vključno z acetilsalicilno kislino  3 g/dan Pri sočasni uporabi zaviralcev ACE in nesteroidnih protivnetnih zdravil (npr. acetilsalicilna kislina v protivnetnih odmerkih, zaviralci COX-2 in neselektivna NSAID) lahko pride do zmanjšanja antihipertenzivnega učinka.
English: “No clinical trials have been carried out which prove the effect of cilazapril on morbidity and mortality in heart failure.”
Slovenian: „Ni bilo izvedenih kliničnih preskušanj, ki bi dokazala učinek cilazaprila na obolevnost in umrljivost pri srčnem popuščanju.“
English: Patients with a strongly activated renin-angiotensin-aldosterone system (in particular, salt and/or volume depletion, cardiac decompensation or severe hypertension) may experience an excessive drop in blood pressure following the initial dose.
Slovenian: Pri bolnikih z močno aktiviranim sistemom renin-angiotenzin-aldosteron (zlasti z izgubo soli in/ali zunajcelične tekočine, dekompenzacijo srca ali hudo hipertenzijo) lahko pride do prekomernega padca krvnega tlaka po začetnem odmerku.
English: The risk of angioedema appears to be greater in black-skinned than non black-skinned patients.
Slovenian: Kot kaže, je tveganje angioedema večje pri bolnikih črne rase kot pri ostalih bolnikih.
English: In such patients a lower starting dose (0.5mg) is recommended and the initiation of treatment should take place under medical supervision.
Slovenian: Pri takih bolnikih je priporočljiv nižji začetni odmerek (0,5 mg), zdravljenje pa se mora začeti pod zdravniškim nadzorom.
English: “Hypersensitivity to cilazapril or any components of the product, or to other ACE inhibitors History of angioedema associated with previous ACE inhibitor therapy Hereditary or idiopathic angioedema
Slovenian: „Preobčutljivost za cilazapril ali druge sestavine zdravila oz. za druge zaviralce ACE Anamneza angioedema v povezavi s predhodnim zdravljenjem z zaviralcem ACE Dedni ali idiopatični angioedem
English: “Hypertension: The initial dose is 1 mg/day.
Slovenian: „Hipertenzija: začetni odmerek je 1 mg/dan.
English: Desensitization: Anaphylactic reactions can occur in patients undergoing desensitization therapy with wasp or bee venom while receiving an ACE inhibitor.
Slovenian: Desenzibilizacija: Anafilaktične reakcije se lahko pojavijo pri bolnikih, pri katerih poteka desenzibilizacijsko zdravljenje s strupom os ali čebel in ki medtem prejemajo zaviralec ACE.
English: Epidemiological studies have suggested that concomitant administration of ACE inhibitors and antidiabetic medicines (insulins, oral hypoglycemic agents) may cause an increased blood-glucoselowering effect with risk of hypoglycemia.
Slovenian: Epidemiološke študije kažejo, da lahko sočasna uporaba zaviralcev ACE in antidiabetikov (insulina, peroralnih antidiabetičnih zdravil) poveča učinek teh zdravil na znižanje glukoze v krvi in s tem tveganje hipoglikemije.
English: If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before you take Vascace.
Slovenian: Če kaj od naštetega velja za vas ali če niste prepričani, se posvetujte z zdravnikom ali s farmacevtom, preden vzamete zdravilo Vascace.
English: Rare (affects less than 1 in 1'000 people)
Slovenian: Redki (pojavijo se pri manj kot 1 od 1.000 bolnikov):
English: Should exposure to ACE inhibitors have occurred from the second trimester of pregnancy, ultrasound examination of renal function and skull is recommended.
Slovenian: V primeru izpostavljenosti zaviralcem ACE od drugega tromesečja nosečnosti dalje je priporočljiv ultrazvočni pregled funkcije ledvic in lobanje.
English: Potassium sparing diuretics (e.g. spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Slovenian: Diuretiki, ki varčujejo s kalijem (npr. spironolakton, triamteren ali amilorid), dodatki kalija ali nadomestki soli, ki vsebujejo kalij, lahko povzročijo pomembna zvečanja serumskih koncentracij kalija.
English: Angiotensin converting enzyme inhibitors, as a class, have been shown to induce adverse effects on the late foetal development, resulting in foetal death and congenital effects, in particular affecting the skull.
Slovenian: Dokazano je bilo, da imajo zaviralci angiotenzinske konvertaze kot razred neželene učinke na pozni razvoj ploda, kar povzroči smrt ploda in kongenitalne učinke, ki vplivajo zlasti na lobanjo.
English: Taking Vascace with food and drink Tell your doctor or pharmacist if you are taking food supplements that contain potassium.
Slovenian: Zdravniku ali farmacevtu morate povedati, če uporabljate prehranske dodatke, ki vsebujejo kalij.
English: Infants whose mothers have taken ACE inhibitors should be closely observed for hypotension (see sections 4.3 and 4.4).
Slovenian: Dojenčke, katerih matere so jemale zaviralce ACE, je treba skrbno pregledati glede hipotenzije (glejte poglavji 4.3 in 4.4).
English: Your doctor may give you other medicines as well as Vascace to help treat your condition.
Slovenian: Morda vam bo zdravnik za zdravljenje vaše bolezni poleg zdravila Vascace predpisal še druga zdravila.
English: ACE inhibitors have established renoprotective effects, but can cause reversible impairment of renal function in the setting of reduced renal perfusion, whether due to bilateral renal artery stenosis, severe congestive heart failure, volume depletion, hyponatraemia or high dosages of diuretics, and in those receiving treatment with NSAIDs.
Slovenian: Zaviralci ACE imajo ugotovljene renoprotektivne učinke, vendar lahko v primeru zmanjšane perfuzije ledvic povzročijo reverzibilno okvaro delovanja ledvic, lahko zaradi obojestranske stenoze ledvične arterije, hudega kongestivnega srčnega popuščanja, hipovolemije, hiponatriemije ali velikih odmerkov diuretikov ter pri bolnikih, ki dobivajo nesteroidna protivnetna zdravila.
English: The recommended starting dose in these patients is 0.5 mg once daily.”
Slovenian: Priporočeni začetni odmerek pri teh bolnikih je 0,5 mg enkrat dnevno.“
English: As with other ACE inhibitors, the blood pressure-lowering effect of Vascace in black patients may be less pronounced than in non-blacks.
Slovenian: Tako kot velja za druge zaviralce ACE, je lahko učinek zdravila Vascace na znižanje krvnega tlaka pri bolnikih črne rase manj izrazit kot pri ostalih bolnikih.
English: Lupus-like syndrome (symptoms may include vasculitis, myalgia, arthralgia/arthritis, positive antinuclear antibodies, increased erythrocyte sedimentation rate, eosinophilia and leukocytosis) Nervous system disorders
Slovenian: Lupusu podobni sindrom (med simptomi so lahko vaskulitis, mialgija, artralgija/artritis, pozitivna protijedrna protitelesa, večja hitrost sedimentacije eritrocitov, eozinofilija in levkocitoza) Bolezni živčevja pogosti glavobol občasni disgevzija redki
English: Hepatic impairment: In patients with liver cirrhosis increased plasma concentrations and reduced plasma and renal clearance were observed, with a greater effect on cilazapril than on its active metabolite cilazaprilat.
Slovenian: Okvara jeter: Pri bolnikih s cirozo jeter so opažali večjo koncentracijo v plazmi in manjši plazemski in ledvični očistek; pri tem je bilo to izrazitejše, kar zadeva cilazapril, kot kar zadeva njegov aktivni presnovek cilazaprilat.
English: Patients receiving cilazapril who develop jaundice or marked elevations of hepatic enzymes should discontinue cilazapril and receive appropriate medical follow-up.
Slovenian: Bolniki, ki dobivajo cilazapril in se jim pojavi ikterus ali občutno zvišanje jetrnih encimov, morajo nehati uporabljati cilazapril in potrebujejo ustrezno zdravniško spremljanje.
English: Hyperkalaemia is most likely to occur in patients with renal impairment and those taking potassium sparing diuretics or potassium supplements.
Slovenian: Hiperkaliemija je najverjetnejša pri bolnikih z okvaro ledvic in tistih, ki jemljejo diuretike, ki varčujejo s kalijem, ali dodatke kalija.
English: The signs include bruising easily and nose bleeds.
Slovenian: Med znaki so nagnjenost h krvavitvam in krvavitve iz nosu.
English: A placebo-controlled study evaluating 1, 2.5 and 5mg once daily.
Slovenian: S placebom nadzorovana študija odmerkov 1; 2,5 in 5 mg enkrat dnevno).
English: Hypertension: The initial dose is 1 mg/day.
Slovenian: Hipertenzija: Začetni odmerek je 1 mg/dan.
English: Second and third trimesters of pregnancy (see sections 4.4. and 4.6)
Slovenian: Drugo in tretje tromesečje nosečnosti (glejte poglavji 4.4 in 4.6).
English: The posolgy recommendation for cilazapril in chronic heart failure is based on effects on symptomatic improvement, rather than on data showing that cilazapril reduces morbidity and mortality in this patient group (see section 5.1).”
Slovenian: Priporočilo glede odmerjanja cilazaprila pri kroničnem srčnem popuščanju temelji na učinkih na simptomatsko izboljšanje in ne toliko na podatkih, ki kažejo, da cilazapril zmanjšuje obolevnost in umrljivost v tej skupini bolnikov (glejte poglavje 5.1)“
English: By suppressing the renin-angiotensin-aldosterone system, Vascace improves loading conditions in the failing heart by reducing systemic vascular resistance (afterload) and pulmonary capillary wedge pressure (preload) in patients on diuretics and/or digitalis.
Slovenian: S supresijo sistema renin-angiotenzin-aldosteron zdravilo Vascace izboljša polnilno stanje popuščajočega srca, ker pri bolnikih, zdravljenih z diuretiki in/ali digitalisom, zmanjša sistemsko žilno upornost (sistolično breme, "afterload") in pljučni kapilarni zagozditveni tlak (predobremenitev, "preload").
English: “Liver cirrhosis: In patients with liver cirrhosis (but without ascites) who require therapy for hypertension, cilazapril should be dosed with great caution not exceeding 0.5 mg/day accompanied by a careful monitoring of the blood pressure, because significant hypotension may occur.”
Slovenian: „Ciroza jeter: pri bolnikih s cirozo jeter (vendar brez ascitesa), pri katerih je potrebno zdravljenje hipertenzije, je treba cilazapril odmerjati zelo previdno v količini, ki ne presega 0,5 mg/dan, hkrati je potrebno skrbno spremljanje krvnega tlaka, saj lahko pride do precejšnje hipotenzije.“
English: It works by making your blood vessels relax and widen.
Slovenian: Deluje tako, da sprosti in razširi žile.
English: Concomitant use of ACE inhibitors and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Slovenian: Sočasna uporaba zaviralcev ACE in NSAID lahko zveča tveganje za poslabšanje delovanja ledvic, vključno z morebitno akutno odpovedjo ledvic, ter zveča serumske koncentracije kalija, še posebej pri bolnikih, ki imajo že od prej poslabšano delovanje ledvic.
English: In such patients, glucose levels should be carefully monitored during initiation of treatment with an ACE inhibitor.
Slovenian: Takšnim bolnikom je treba med uvedbo in zdravljenjem z zaviralcem ACE natančno kontrolirati koncentracijo glukoze.
English: Renal impairment: In patients with renal impairment, higher plasma concentrations of cilazaprilat are observed than in patients with normal renal function, since drug clearance is reduced when creatinine clearance is lower.
Slovenian: Okvara ledvic: Pri bolnikih z okvaro ledvic je koncentracija cilazaprilata v plazmi večja kot pri bolnikih z normalnim delovanjem ledvic, ker se z zmanjšanjem očistka kreatinina zmanjša tudi očistek zdravila.
English: The CHMP agreed with the following wording proposed by the MAH for the elderly and paediatric populations:
Slovenian: CHMP se je strinjal z naslednjim besedilom, ki ga je predlagal imetnik dovoljenja za promet z zdravilom pri starejših populacijah in otrocih:
English: - if you have severe liver problems or if you develop jaundice.
Slovenian: - če imate hude težave z jetri ali se pri vas pojavi zlatenica.
English: the CHMP has recommended the amendment of the Marketing Authorisations for which the Summary of Product Characteristics, labelling and package leaflet are set out in Annex III for Vascase and associated names (see Annex I).
Slovenian: CHMP je priporočil dopolnitev dovoljenj za promet z zdravilom Vascase in z njim povezanimi imeni (glejte Dodatek I), katerih povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo so navedeni v Dodatku III.
English: These developmental anomalies are thought to be partly due to a direct action of ACE inhibitors on the foetal renin-angiotensin system and partly due to ischaemia resulting from maternal hypotension and decreases in foetal-placental blood flow and oxygen/nutrients delivery to the foetus.
Slovenian: Te razvojne nepravilnosti so domnevno deloma posledica neposrednega delovanja zaviralcev ACE na plodov sistem renin-angiotenzin, deloma pa ishemije, ki nastane zaradi hipotenzije pri materi in zmanjša fetoplacentni pretok krvi ter oskrbo ploda s kisikom in hranili.
English: Thus, dosage adjustments beyond those recommended for patients with impaired renal function (see section 4.2) should not be necessary.
Slovenian: Zato odmerka ni treba prilagajati bolj, kot je priporočeno za bolnike z okvarjenim delovanjem ledvic (glejte poglavje 4.2).
English: Exposure to ACE inhibitor therapy during the second and third trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia).
Slovenian: Znano je, da izpostavljenost zdravljenju z zaviralci ACE v drugem in tretjem tromesečju povzroči humano fetotoksičnost (zmanjšano ledvično funkcijo, oligohidramniozo, zakasnitev okostenitve lobanje) in neonatalno toksičnost (okvaro ledvic, hipotenzijo, hiperkalemijo).
English: This belongs to a group of medicines called ‘ACE inhibitors' (Angiotensin Converting Enzyme Inhibitors).
Slovenian: Ta učinkovina spada v skupino zdravil, ki jih imenujemo "zaviralci ACE" (zaviralci angiotenzinske konvertaze).
English: These developmental anomalies are thought to be partly due to a direct action of ACE inhibitors on the foetal renin-angiotensin system and partly due to ischaemia resulting from maternal hypotension and decreases in foetal-placental blood flow and oxygen/nutrients delivery to the foetus.”
Slovenian: Vzrok teh razvojnih anomalij naj bi bil delno neposreden učinek zaviralcev ACE na sistem renin-angiotenzin pri plodu in delno ishemija, ki izvira iz hipotenzije pri materi in zmanjšanja pretoka krvi med plodom in posteljico ter oskrbe plodu s kisikom/hranilnimi snovmi.“
English: The warning concerning anaphylaxis in dialysis patients receiving ACE inhibitors is discussed under a separate subheading in Section 4.4, “Anaphylaxis”.
Slovenian: Opozorilo glede anafilakse pri bolnikih na dializi, ki prejemajo zaviralce ACE, je pojasnjeno v ločenem podnaslovu v poglavju 4.4.
English: The posology recommendation for cilazapril in chronic heart failure is based on effects on symptomatic improvement, rather than on data showing that cilazapril reduces morbidity and mortality in this patient group (see section 5.1).
Slovenian: Priporočila za odmerjanje cilazaprila pri kroničnem srčnem popuščanju temeljijo na vplivu na izboljšanje simptomov, ne pa na podatkih, ki bi dokazovali, da cilazapril zmanjša obolevnost in smrtnost v tej skupini bolnikov (glejte poglavje 5.1).
English: Surgery/anaesthesia
Slovenian: Operacije/anestezija
English: The usual dose range of Vascace is 2.5 to 5.0 mg once daily.
Slovenian: Običajen razpon odmerkov zdravila Vascace je od 2,5 do 5,0 mg enkrat na dan.
English: Symptoms associated with overdosage of ACE inhibitors may include hypotension, circulatory shock, electrolyte disturbances, renal failure, hyperventilation, tachycardia, palpitations, bradycardia, dizziness, anxiety and cough.
Slovenian: Med simptomi, povezanimi s prevelikim odmerjanjem zaviralcev ACE, so lahko hipotenzija, cirkulacijski šok, elektrolitske motnje, odpoved ledvic, hiperventilacija, tahikardija, palpitacije, bradikardija, omotica, anksioznost in kašelj.
English: - Feeling dizzy - Coughing - Nausea - Feeling tired - Headache
Slovenian: - omotica, - kašelj, - slabost v želodcu (siljenje na bruhanje), - utrujenost, - glavobol.
English: In patients with liver cirrhosis (but without ascites) who require therapy for hypertension, cilazapril should be initiated at a lower dose and with great caution because significant hypotension may occur (see section 4.2).
Slovenian: Bolnikom s cirozo jeter (a brez ascitesa), ki potrebujejo zdravljenje hipertenzije, je treba cilazapril uvesti v manjšem odmerku in zelo previdno, ker se lahko pojavi izrazita hipotenzija (glejte poglavje 4.2).
English: Foetotoxicity, intrauterine growth retardation and patent ductus arteriosus have also been reported.
Slovenian: Poročali so tudi o fetotoksičnosti, znotrajmaterničnem zastoju rasti in odprtju arterioznega duktusa.
English: Therefore, the combination of cilazapril with the above-mentioned drugs is not recommended (see section 4.4).
Slovenian: Sočasna uporaba cilazaprila z omenjenimi zdravili torej ni priporočljiva (glejte poglavje 4.4).
English: MARKETING AUTHORISATION HOLDER [To be completed nationally] [See Annex I - To be completed nationally] {Name and address} {tel} {fax} {e-mail}
Slovenian: IMETNIK DOVOLJENJA ZA PROMET [Izpolni država članica] [Glejte Dodatek I - Izpolni država članica] {Ime in naslov} {tel}
English: The signs include severe pain in the stomach which spreads to your back - Changes in the way your liver or kidneys work (shown in blood and urine tests) - Liver problems such as hepatitis (inflammation of the liver) or liver damage - Severe skin reactions including blistering or peeling of skin - Increased sensitivity to light - Hair loss (which may be temporary) - Loosening or separation of a nail from its bed - Breast enlargement in men
Slovenian: Med znaki je huda bolečina v zgornjem delu trebuha, ki se širi v hrbet; - spremenjeno delovanje jeter ali ledvic (kaže se s spremenjenimi izvidi preiskav krvi in urina), - težave z jetri, npr. hepatitis (vnetja jeter) ali okvara jeter, - hude kožne reakcije, vključno z nastajanjem mehurjev ali lupljenjem kože, - večja občutljivost za svetlobo, - izpadanje las (ki je lahko prehodno), - zrahljanje nohtov ali njihovo odstopanje z nohtne posteljice, - povečanje prsi pri moških.
English: ACE inhibitors are less effective as antihypertensives in patients with black skin colour.
Slovenian: Zaviralci ACE so kot antihipertenzivi manj učinkoviti pri bolnikih črne rase.
English: Reduced doses are required for patients with renal impairment depending on their creatinine clearance.
Slovenian: Zmanjšani odmerki so potrebni pri bolnikih z okvaro ledvic, pri čemer je treba upoštevati njihov očistek kreatinina.
English: Psoriaform dermatitis, psoriasis (exacerbation), lichen planus, exfoliative dermatitis, urticaria, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous pemphigoid, pemphigus, Karposi's sarcoma, vasculitis/purpura, photosensitivity reactions, alopecia, onycholysis Musculoskeletal and connective tissue disorders Uncommon
Slovenian: Bolezni kože in podkožja občasni izpuščaj, makulopapulozen izpuščaj redki psoriaziformni dermatitis, psoriaza (poslabšanje), lihen planus, eksfoliativni dermatitis, urtikarija, multiformni eritem, Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, bulozni pemfigoid, pemfigus, Kaposijev sarkom, vaskulitis, purpura, fotosenzibilnostne reakcije, alopecija, oniholiza Bolezni mišično-skeletnega sistema in vezivnega tkiva občasni mišični krči, mialgija, artralgija