FrancophonIA/ELRC3.0 huggingface dataset:
English: Aerius oral solution with food, drink and alcohol Aerius may be taken with or without a meal.
Croatian: Aerius oralna otopina s hranom, pićem i alkoholom Aerius se može uzeti uz ili bez obroka.
English: Aerius 2.5 mg orodispersible tablet is light red, speckled, and round with “K” branded on one side.
Croatian: Aerius 2,5 mg raspadljiva tableta za usta je svijetlocrvena, točkasta i okrugla tableta, s oznakom "K" na jednoj strani.
English: Aerius 5 mg orodispersible tablet is light red, speckled, and round with “A” branded on one side.
Croatian: Aerius 5 mg raspadljiva tableta za usta je svijetlocrvena, točkasta i okrugla tableta, s oznakom "A" na jednoj strani.
English: There is no data available on male/female fertility.
Croatian: Nisu dostupni podaci o plodnosti u muškaraca/žena.
English: Elevations of liver enzymes, increased bilirubin, hepatitis
Croatian: Poremećaji jetre i žuči vrlo rijetko nepoznato povišenje jetrenih enzima, povišeni bilirubin, hepatitis žutica
English: Aerius is supplied in blisters comprised of laminate blister film with foil lidding.
Croatian: Aerius je dostupan u blisterima, a napravljeni su od laminiranog blister filma prekrivenog folijom.
English: During the marketing of Aerius, the following side effects were reported as:
Croatian: Nakon stavljanja u promet lijeka Aerius, sljedeće su nuspojave prijavljene kao:
English: In clinical pharmacology trials in adults, co-administration with alcohol did not increase the alcoholinduced impairment in performance or increase in sleepiness.
Croatian: U kliničkim farmakološkim ispitivanjima u odraslih, istovremena primjena desloratadina i alkohola nije pojačala štetne učinke alkohola na ponašanje ili povećala pospanost.
English: Tablet core: calcium hydrogen phosphate dihydrate, microcrystalline cellulose, maize starch, talc.
Croatian: Jezgra tablete: kalcijev hidrogenfosfat dihidrat; celuloza, mikrokristalična; kukuruzni škrob; talk.
English: Use in children and adolescents Do not give this medicine to children less than 1 year of age.
Croatian: Ovaj lijek se ne smije davati djeci mlađoj od 1 godine.
English: 30 ml with 1 spoon 50 ml with 1 spoon 60 ml with 1 spoon 100 ml with 1 spoon 120 ml with 1 spoon 150 ml with 1 spoon 150 ml with 1 oral syringe 225 ml with 1 spoon 300 ml with 1 spoon
Croatian: 30 ml s 1 žličicom 50 ml s 1 žličicom 60 ml s 1 žličicom 100 ml s 1 žličicom 120 ml s 1 žličicom 150 ml s 1 žličicom 150 ml s 1 štrcaljkom za usta 225 ml s 1 žličicom 300 ml s 1 žličicom
English: What Aerius orodispersible tablet is and what it is used for
Croatian: Što je Aerius raspadljiva tableta za usta i za što se koristi
English: If you take more Aerius oral solution than you should Take Aerius oral solution only as it is prescribed for you.
Croatian: Ako uzmete više Aerius oralne otopine nego što ste trebali Uzimajte Aerius oralnu otopinu samo na način kako Vam je propisano.
English: What you need to know before you take Aerius orodispersible tablet
Croatian: Što morate znati prije nego počnete uzimati Aerius raspadljive tablete za usta
English: Before using, carefully peel open the blister and remove the dose of orodispersible tablet without crushing it. Place it in your mouth and it will disperse immediately.
Croatian: Prije uzimanja lijeka pažljivo odlijepite blister i izvadite raspadljivu tabletu za usta pazeći da je ne zdrobite.
English: For the 150 ml package, a measuring spoon or an oral measuring syringe is provided, marked for doses of 2.5 ml and 5 ml.
Croatian: U pakiranju od 150 ml priložena je odmjerna žličica ili odmjerna štrcaljka za usta s oznakama za doze od 2,5 ml i 5 ml.
English: If your allergic rhinitis is persistent (presence of symptoms for 4 days or more per week and for more than 4 weeks), your physician may recommend you a longer term treatment.
Croatian: Ako bolujete od perzistentnog alergijskog rinitisa (simptomi su prisutni 4 ili više dana u tjednu i duže od 4 tjedna) liječnik Vam može propisati dugotrajnije liječenje.
English: This medicinal product contains sorbitol; thus, patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim problemima nepodnošenja fruktoze, malapsorpcijom glukoze i galaktoze ili insuficijencijom sukraze-izomaltaze ne bi trebali uzimati ovaj lijek.
English: Aerius orodispersible tablets are supplied in unit dose blisters comprised of laminate blister film with foil lidding.
Croatian: Aerius raspadljive tablete za usta dostupne su u blisterima djeljivima na jedinične doze koji su napravljeni od laminiranog blister filma prekrivenog folijom.
English: This product contains 2.9 mg of phenylalanine per 5 mg dose of Aerius orodispersible tablet.
Croatian: Ovaj lijek sadrži 2,9 mg fenilalanina po dozi Aerius raspadljive tablete za usta od 5 mg.
English: This product contains 1.4 mg of phenylalanine per 2.5 mg dose of Aerius orodispersible tablet.
Croatian: Ovaj lijek sadrži 1,4 mg fenilalanina po dozi Aerius raspadljive tablete za usta od 2,5 mg.
English: In the multiple-dose study, steady state was reached after Day 11, and compared to healthy subjects the exposure to desloratadine was ~1.5-fold greater in subjects with mild to moderate CRI and ~2.5-fold greater in subjects with severe CRI.
Croatian: U ispitivanju višekratnih doza, stanje dinamičke ravnoteže postignuto je nakon 11. dana ispitivanja, a u usporedbi s zdravim ispitanicima izloženost desloratadinu bila je približno 1,5 puta viša u ispitanika s blagom do umjerenom kroničnom insuficijencijom bubrega te približno 2,5 puta viša u ispitanika s teškom kroničnom insuficijencijom bubrega.
English: Adults and adolescents (12 years of age and over) The recommended dose of Aerius is one tablet once a day.
Croatian: Odrasli i adolescenti (u dobi od 12 godina i stariji) Preporučena doza lijeka Aerius je jedna tableta jedanput na dan.
English: Name and address of the manufacturer responsible for batch release for film-coated tablets
Croatian: Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet za filmom obložene tablete
English: Aerius 5 mg film-coated tablets are packed in blisters in packs of 1, 2, 3, 5, 7, 10, 14, 15, 20, 21, 30, 50, 90 or 100 tablets.
Croatian: Aerius 5 mg filmom obložene tablete pakirane su u blistere, u veličinama pakiranja od 1, 2, 3, 5, 7, 10, 14, 15, 20, 21, 30, 50, 90 ili 100 tableta.
English: At the recommended dose, Aerius 5 mg orodispersible tablet was found to be bioequivalent to the Aerius 5 mg conventional tablet formulation of desloratadine.
Croatian: Utvrđeno je da je Aerius 5 mg raspadljiva tableta za usta u preporučenoj dozi bioekvivalentna formulaciji desloratadina u obliku konvencionalne Aerius 5 mg tablete.
English: In clinical pharmacology trials, co-administration with alcohol did not increase the alcohol-induced impairment in performance or increase in sleepiness.
Croatian: U kliničkim farmakološkim ispitivanjima, istovremena primjena desloratadina i alkohola nije pojačala štetne učinke alkohola na ponašanje ili povećala pospanost.
English: Aerius is an antiallergy medicine that does not make you drowsy.
Croatian: Aerius je lijek protiv alergije koji ne izaziva pospanost.
English: ● muscle pain
Croatian: ● bol u mišićima
English: Do not take Aerius - if you are allergic to desloratadine, or any of the other ingredients of this medicine (listed in section 6) or to loratadine.
Croatian: Nemojte uzimati Aerius - ako ste alergični na desloratadin, neki drugi sastojak ovog lijeka (naveden u dijelu 6.) ili na loratadin.
English: Aerius orodispersible tablet is an antiallergy medicine that does not make you drowsy.
Croatian: Aerius raspadljiva tableta za usta je lijek protiv alergije koji ne izaziva pospanost.
English: If you forget to take Aerius oral solution
Croatian: Ako ste zaboravili uzeti Aerius oralnu otopinu
English: ● fever
Croatian: ● vrućica
English: Dizziness, somnolence, insomnia, psychomotor hyperactivity, seizures
Croatian: Poremećaji živčanog sustava često vrlo rijetko glavobolja omaglica, somnolencija, nesanica, psihomotorička hiperaktivnost, napadaji
English: Children 6 to 11 years of age: the recommended dose of Aerius is one 2.5 mg orodispersible tablet placed in mouth once a day.
Croatian: Djeca u dobi od 6 do 11 godina: preporučena doza lijeka Aerius je jedna raspadljiva tableta za usta od 2,5 mg koja se stavlja u usta jedanput na dan.
English: In the single-dose study, the exposure to desloratadine was approximately 2 and 2.5-fold greater in subjects with mild to moderate and severe CRI, respectively, than in healthy subjects.
Croatian: U ispitivanju jednokratnih doza, izloženost desloratadinu bila je približno 2 puta viša u ispitanika s blagom do umjerenom kroničnom insuficijencijom bubrega, i 2,5 puta viša u ispitanika s teškom kroničnom insuficijencijom bubrega, nego u zdravih ispitanika.
English: Aerius is indicated in adults, adolescents and children over the age of 1 year for the relief of symptoms associated with: - allergic rhinitis (see section 5.1) - urticaria (see section 5.1)
Croatian: Aerius je indiciran u odraslih, adolescenata i djece starije od 1 godine za ublažavanje simptoma povezanih s: - alergijskim rinitisom (vidjeti dio 5.1) - urtikarijom (vidjeti dio 5.1)
English: 6.1 List of excipients microcrystalline cellulose pregelatinized starch sodium starch glycolate magnesium stearate butylated methacrylate copolymer crospovidone sodium hydrogen carbonate citric acid colloidal silicon dioxide ferric oxide mannitol aspartame (E951) flavour Tutti-Frutti
Croatian: 6.1 Popis pomoćnih tvari celuloza, mikrokristalična škrob, prethodno geliran natrijev škroboglikolat magnezijev stearat kopolimer (butadien/metakrilat) krospovidon natrijev hidrogenkarbonat citratna kiselina silicijev dioksid, koloidni željezov oksid manitol aspartam (E951) aroma Tutti-Frutti
English: Regarding the duration of treatment, your physician will determine the type of allergic rhinitis you are suffering from and will determine for how long you should take Aerius.
Croatian: Vezano za trajanje liječenja, Vaš će liječnik odrediti od kojeg tipa alergijskog rinitisa bolujete te koliko dugo trebate uzimati Aerius.
English: Aerius 0.5 mg/ml oral solution desloratadine
Croatian: Aerius 0,5 mg/ml oralna otopina desloratadin
English: Children 6 through 11 years of age: The recommended dose is 5 ml (one 5 ml spoonful) of oral solution once a day.
Croatian: Djeca u dobi od 6 do 11 godina: Preporučena doza je 5 ml (jedna žličica od 5 ml) oralne otopine jedanput na dan.
English: Treatment was well tolerated as documented by clinical laboratory tests, vital signs, and ECG interval data, including QTc.
Croatian: Sudeći prema nalazima kliničkih laboratorijskih testova, vitalnim znakovima i nalazima EKG intervala, uključujući QTc interval, djeca su dobro podnosila liječenje.
English: Use in children and adolescents Do not give this medicine to children less than 6 years of age.
Croatian: Ovaj lijek se ne smije davati djeci mlađoj od 6 godina.
English: What Aerius oral solution contains
Croatian: Što Aerius oralna otopina sadrži
English: The safety and efficacy of Aerius 0.5 mg/ml oral solution in children below the age of 1 year have not been established.
Croatian: Sigurnost i djelotvornost lijeka Aerius 0,5 mg/ml oralna otopina u djece mlađe od 1 godine nisu ustanovljene.
English: Aerius has no or negligible influence on the ability to drive and use machines based on clinical trials.
Croatian: Temeljem rezultata kliničkih ispitivanja Aerius ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: What Aerius oral solution is and what it is used for
Croatian: Što je Aerius oralna otopina i za što se koristi
English: In clinical studies in adults, side effects were about the same as with a dummy tablet.
Croatian: U kliničkim ispitivanjima u odraslih osoba, nuspojave su bile slične s onima kod uzimanja tablete placeba.
English: Aerius 0.5 mg/ml oral solution
Croatian: Aerius 0,5 mg/ml oralna otopina
English: Aerius is also used to relieve the symptoms associated with urticaria (a skin condition caused by an allergy).
Croatian: Aerius se također koristi za ublažavanje simptoma povezanih s urtikarijom (promjene na koži uslijed alergije).
English: Use in children and adolescents Do not give this medicine to children less than 12 years of age.
Croatian: Ovaj lijek se ne smije davati djeci mlađoj od 12 godina.
English: Aerius tablets given at a single daily dose of 7.5 mg to adults and adolescents did not affect psychomotor performance in clinical trials.
Croatian: Aerius tablete primijenjene u jednokratnoj dnevnoj dozi od 7,5 mg odraslima i adolescentima nisu imale učinak na psihomotorne sposobnosti u kliničkim ispitivanjima.
English: Maximum desloratadine concentration was about 3-fold higher at approximately 7 hours with a terminal phase half-life of approximately 89 hours.
Croatian: Maksimalna koncentracija desloratadina bila je oko 3 puta veća nakon približno 7 sati od primjene, s poluvijekom u terminalnoj fazi od oko 89 sati.
English: This medicine is for oral use.
Croatian: Ovaj lijek je namijenjen za primjenu kroz usta.
English: Regarding the duration of treatment, your physician will determine the type of allergic rhinitis you are suffering from and will determine for how long you should take Aerius orodispersible tablets.
Croatian: Vezano za trajanje liječenja, Vaš će liječnik odrediti od kojeg tipa alergijskog rinitisa bolujete te koliko dugo trebate uzimati Aerius raspadljive tablete za usta.
English: When Aerius should be used
Croatian: Kada treba uzimati Aerius
English: Tablet coating: film coat (containing lactose monohydrate, hypromellose, titanium dioxide, macrogol 400, indigotin (E132)), clear coat (containing hypromellose, macrogol 400), carnauba wax, white wax.
Croatian: Ovojnica tablete: film ovojnica (sadrži laktozu hidrat, hipromelozu, titanijev dioksid, makrogol 400, indigotin (E132)), prozirna ovojnica (sadrži hipromelozu, makrogol 400), karnauba vosak, bijeli vosak.
English: ● fast heartbeat
Croatian: ● ubrzani otkucaji srca
English: Aerius given at a single daily dose of 7.5 mg did not affect psychomotor performance in clinical trials.
Croatian: Aerius primijenjen u jednokratnoj dnevnoj dozi od 7,5 mg nije imao učinak na psihomotorne sposobnosti u kliničkim ispitivanjima.
English: Children 6 through 11 years of age: 5 ml (2.5 mg) Aerius oral solution once a day.
Croatian: Djeca u dobi od 6 do 11 godina: 5 ml (2,5 mg) Aerius oralne otopine jedanput na dan.
English: What you need to know before you take Aerius oral solution
Croatian: Što morate znati prije nego počnete uzimati Aerius oralnu otopinu
English: Do not take Aerius orodispersible tablet - if you are allergic to desloratadine, or any of the other ingredients of this medicine (listed in section 6) or to loratadine.
Croatian: Nemojte uzimati Aerius raspadljive tablete za usta - ako ste alergični na desloratadin, neki drugi sastojak ovog lijeka (naveden u dijelu 6.) ili na loratadin.
English: What Aerius orodispersible tablet looks like and contents of the pack
Croatian: Kako Aerius raspadljiva tableta za usta izgleda i sadržaj pakiranja
English: Tablet coating contains film coat (containing lactose monohydrate, hypromellose, titanium dioxide, macrogol 400, indigotin (E132)), clear coat (containing hypromellose, macrogol 400), carnauba wax, white wax.
Croatian: Ovojnica tablete sadrži: film ovojnicu (koja sadrži laktozu hidrat, hipromelozu, titanijev dioksid, makrogol 400, indigotin (E132)), prozirnu ovojnicu (koja sadrži hipromelozu, makrogol 400), karnauba vosak i bijeli vosak.
English: In a multiple dose clinical trial, in which up to 20 mg of desloratadine was administered daily for 14 days, no statistically or clinically relevant cardiovascular effect was observed.
Croatian: U kliničkom ispitivanju višestrukih doza, u kojem se primjenjivalo do 20 mg desloratadina na dan tijekom 14 dana, nije uočen klinički ili statistički značajan kardiovaskularni učinak.
English: Each ml of oral solution contains 0.5 mg desloratadine.
Croatian: Jedan ml oralne otopine sadrži 0,5 mg desloratadina.
English: Aerius is indicated in adults, adolescents aged 12 years and older and children aged 6 - 11 years old for the relief of symptoms associated with: - allergic rhinitis (see section 5.1) - urticaria (see section 5.1)
Croatian: Aerius je indiciran u odraslih i adolescenata u dobi od 12 ili više godina, te u djece u dobi od 6 do 11 godina za ublažavanje simptoma povezanih s: - alergijskim rinitisom (vidjeti dio 5.1) - urtikarijom (vidjeti dio 5.1)
English: Do not take Aerius oral solution - if you are allergic to desloratadine, or to any of the other ingredients of this medicine (listed in section 6) or to loratadine.
Croatian: Nemojte uzimati Aerius oralnu otopinu - ako ste alergični na desloratadin, neki drugi sastojak ovog lijeka (naveden u dijelu 6.) ili na loratadin.
English: Children from 6 to 11 years of age The recommended dose is one tablet once a day with or without food.
Croatian: Djeca u dobi od 6 do 11 godina Preporučena doza je jedna tableta jedanput na dan, uz obrok ili natašte.
English: Aerius is indicated in adults and adolescents aged 12 years and older for the relief of symptoms associated with: - allergic rhinitis (see section 5.1) - urticaria (see section 5.1)
Croatian: Aerius je indiciran u odraslih i adolescenata u dobi od 12 ili više godina za ublažavanje simptoma povezanih s: - alergijskim rinitisom (vidjeti dio 5.1) - urtikarijom (vidjeti dio 5.1)
English: In controlled clinical trials, at the recommended dose of 5 mg daily for adults and adolescents, there was no excess incidence of somnolence as compared to placebo.
Croatian: U kontroliranim kliničkim ispitivanjima, kod preporučene doze za odrasle i adolescente od 5 mg na dan, nije bila povećana incidencija somnolencije u usporedbi s placebom.
English: In a clinical pharmacology trial, in adults and adolescents, in which desloratadine was administered to adults at a dose of 45 mg daily (nine times the clinical dose) for ten days, no prolongation of QTc interval was seen.
Croatian: U kliničkom farmakološkom ispitivanju u odraslih i adolescenata, u kojem se desloratadin primjenjivao odraslima u dozi od 45 mg na dan (devet puta većoj dozi od kliničke) tijekom deset dana, nije opaženo produljenje QTc intervala.
English: In adult and adolescent patients with allergic rhinitis, Aerius tablets were effective in relieving symptoms such as sneezing, nasal discharge and itching, as well as ocular itching, tearing and redness, and itching of palate.
Croatian: U odraslih i adolescentskih bolesnika s alergijskim rinitisom, Aerius tablete su bile učinkovite u ublažavanju simptoma kao što su kihanje, curenje i svrbež nosa, kao i svrbež, suzenje i crvenilo očiju te svrbež nepca.
English: Marketing Authorisation Holder: Merck Sharp & Dohme B.V. Waarderweg 39
Croatian: Nositelj odobrenja za stavljanje gotovog lijeka u promet: Merck Sharp & Dohme B.V.
English: What Aerius orodispersible tablet contains
Croatian: Što Aerius raspadljiva tableta za usta sadrži
English: In a clinical pharmacology trial, in which desloratadine was administered at a dose of 45 mg daily (nine times the clinical dose) for ten days, no prolongation of QTc interval was seen.
Croatian: U kliničkom farmakološkom ispitivanju u kojem se desloratadin primjenjivao u dozi od 45 mg na dan (devet puta većoj dozi od kliničke) tijekom deset dana, nije opaženo produljenje QTc intervala.
English: What Aerius oral solution is and what it is used for What you need to know before you take Aerius oral solution How to take Aerius oral solution Possible side effects
Croatian: Što je Aerius oralna otopina i za što se koristi Što morate znati prije nego počnete uzimati Aerius oralnu otopinu Kako uzimati Aerius oralnu otopinu Moguće nuspojave
English: - The active substance is desloratadine 0.5 mg/ml - The other ingredients of the oral solution are sorbitol, propylene glycol, sucralose E 955, hypromellose 2910, sodium citrate dihydrate, natural and artificial flavour (bubblegum), citric acid anhydrous, disodium edetate and purified water.
Croatian: - Drugi sastojci oralne otopine su sorbitol, propilenglikol, sukraloza (E955), hipromeloza 2910, natrijev citrat dihidrat, prirodna i umjetna aroma (žvakaća guma), bezvodna citratna kiselina, dinatrijev edetat i pročišćena voda.
English: Aerius tablets given at a single daily dose of 7.5 mg did not affect psychomotor performance in clinical trials.
Croatian: Aerius tablete primijenjene u jednokratnoj dnevnoj dozi od 7,5 mg nisu imale učinak na psihomotorne sposobnosti u kliničkim ispitivanjima.
English: Aerius orodispersible tablet is packed in unit dose blisters in packs of 5, 6, 10, 12, 15, 18, 20, 30, 50, 60, 90 and 100 doses of orodispersible tablet.
Croatian: Aerius raspadljive tablete za usta pakirane su u blistere djeljive na jedinične doze, u veličinama pakiranja od 5, 6, 10, 12, 15, 18, 20, 30, 50, 60, 90 i 100 raspadljivih tableta za usta.
English: These symptoms include sneezing, runny or itchy nose, itchy palate, and itchy, red or watery eyes.
Croatian: Ti simptomi uključuju kihanje, curenje ili svrbež nosa, svrbež nepca te svrbež, crvenilo i suzenje očiju.
English: Regarding the duration of treatment, your physician will determine the type of allergic rhinitis you are suffering from and will determine for how long you should take Aerius oral solution.
Croatian: Vezano za trajanje liječenja, Vaš će liječnik odrediti od kojeg tipa alergijskog rinitisa bolujete te koliko dugo trebate uzimati Aerius oralnu otopinu.
English: Name and address of the manufacturer responsible for batch release for orodispersible tablet
Croatian: Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet za raspadljive tablete za usta
English: Based on a multiple dose clinical trial in adults and adolescents, in which up to 45 mg of desloratadine was administered (nine times the clinical dose), no clinically relevant effects were observed.
Croatian: Na temelju kliničkog ispitivanja višestrukih doza u odraslih i adolescenata, u kojem su primijenjene doze do 45 mg desloratadina (devet puta veće od kliničke doze), nisu zabilježeni klinički značajni učinci.
English: Aerius orodispersible tablet is also used to relieve the symptoms associated with urticaria (a skin condition caused by an allergy).
Croatian: Aerius raspadljiva tableta za usta se također koristi za ublažavanje simptoma povezanih s urtikarijom (promjene na koži uslijed alergije).
English: In an additional study, no adverse events were seen in subjects between 6 and 11 years of age following a single 2.5 mg dose of desloratadine oral solution.
Croatian: U dodatnom ispitivanju nakon primjene jednokratne doze desloratadin oralne otopine od 2,5 mg u ispitanika između 6 i 11 godina nisu opažene nuspojave.
English: In a multiple dose clinical trial, in adults and adolescents, in which up to 20 mg of desloratadine was administered daily for 14 days, no statistically or clinically relevant cardiovascular effect was observed.
Croatian: U kliničkom ispitivanju višestrukih doza u odraslih i adolescenata, u kojem se primjenjivalo do 20 mg desloratadina na dan tijekom 14 dana, nije uočen klinički ili statistički značajan kardiovaskularni učinak.
English: Adults and adolescents (12 years of age and over) The recommended dose of Aerius is one 5 mg orodispersible tablet placed in the mouth once a day.
Croatian: Odrasli i adolescenti (u dobi od 12 godina i stariji) Preporučena doza lijeka Aerius je jedna raspadljiva tableta za usta od 5 mg koja se stavlja u usta jedanput na dan.