FrancophonIA/ELRC3.0 huggingface dataset:
English: Among all randomised and treated patients, the median change from baseline in HIV-1 RNA at the last measurement up to Week 48 was -0.64 log10 copies/ml in patients receiving tipranavir with ritonavir versus -0.22 log10 copies/ml in the comparator PI/ritonavir arm.
Croatian: Uzimajući u obzir sve randomizirane i liječene bolesnike medijan razlike HIV-1 RNA između zadnjeg mjerenja (najdulje nakon 48 tjedana) i vrijednosti prije početka liječenja, iznosio je -0,64 log10 kopija/ml za ispitivanu i0,22 log10 kopija/ml za kontrolnu skupinu.
English: The combined use of Aptivus, coadministered with low dose ritonavir, with proton pump inhibitors is not recommended (see section 4.4).
Croatian: Kombinirana primjena Aptivusa s niskom dozom ritonavira i inhibitora protonske pumpe se ne preporučuje (vidjeti dio 4.4).
English: Aptivus oral solution co-administered with low dose oral solution ritonavir should be taken with food (see section 5.2).
Croatian: Aptivus oralna otopina, primijenjena istodobno s niskom dozom oralne otopine ritonavira, uzima se s hranom (vidjeti dio 5.2).
English: With respect to mutations on codons 33, 82, 84 and 90 approximately 4% had no mutations, 24% had mutations at codons 82 (less than 1% of patients had the mutation V82L) and 90, 18% had mutations at codons 84 and 90 and 53% had at least one key mutation at codon 90.
Croatian: Na početku studija, medijan broja mutacija u genu za proteazu iznosio je 16, a medijan broja primarnih mutacija gena za proteazu - D30N, L33F/I, V46I/L, G48V, I50V, V82A/F/T/L, I84V, i L90M - iznosio je 3. S obzirom na mutacije na kodonima 33, 82, 84 i 90, oko 4% bolesnika imalo je viruse bez mutacija, 24% je imalo mutacije na kodonima 82 (manje od 1% bolesnika je imalo mutaciju V82L) i 90, 18% je imalo mutacije na kodonima 84 i 90, a 53% imalo je najmanje jednu ključnu mutaciju na kodonu 90.
English: If a dose is missed by less than 5 hours, the patient should be instructed to take the missed dose immediately, and then to take the next dose of Aptivus and ritonavir at the regularly scheduled time.
Croatian: U slučaju propuštanja doze za manje od 5 sati, bolesnika je potrebno uputiti da odmah uzme propuštenu dozu, te da zatim uzme sljedeću dozu Aptivusa i ritonavira u redovno vrijeme prema režimu doziranja.
English: The clinical relevance of this reduction in amprenavir concentrations has not been established.
Croatian: Klinički značaj ovog smanjenja koncentracija amprenavira nije utvrđen.
English: administered with low dose ritonavir, should be separated by at least 2 hours to avoid formulation incompatibility.
Croatian: Primjena želučanootporne formulacije didanozina i Aptivus mekih kapsula s niskom dozom ritonavira mora biti odvojena najmanje 2 sata radi izbjegavanja inkompatibilnosti formulacija.
English: Based on theoretical considerations tipranavir, co-administered with low dose ritonavir, is expected to increase itraconazole or ketoconazole concentrations.
Croatian: Temeljem teoretskih razmatranja, očekuje se da tipranavir s niskom dozom ritonavira povećava koncentracije itrakonazola ili ketokonazola.
English: Aptivus with ritonavir should not be used in treatment-naïve patients.
Croatian: Aptivus s ritonavirom se ne smije primjenjivati u bolesnika koji prethodno nisu liječeni antiretrovirusnim lijekovima.
English: CYP 3A4 inhibition by tipranavir/r co-administered with low dose ritonavir, with alfuzosin is contraindicated.
Croatian: CYP 3A4 inhibicija putem tipranavira/r alfuzosina je kontraindicirana.
English: The concomitant use of Aptivus, coadministered with low dose ritonavir with zidovudine is not recommended unless there are no other available NRTIs suitable for patient management.
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i zidovudina se ne preporučuje, osim ako on nije jedini NRTI prikladan za zbrinjavanje bolesnika.
English: No interaction study performed
Croatian: Nije provedeno ispitivanje interakcija
English: Tipranavir phenotypic resistance
Croatian: Fenotipska otpornost na tipranavir
English: Switching from Aptivus capsules to the oral solution Aptivus capsules are not interchangeable with the oral solution.
Croatian: Aptivus kapsule nisu zamjenjive s oralnom otopinom.
English: Lamivudine 150 mg BID (TPV/r 750/100 mg BID)
Croatian: Lamivudin 150 mg BID (TPV/r 750/100 mg BID)
English: Coadministration of Aptivus with ritonavir, with St. John's wort is expected to substantially decrease tipranavir and ritonavir concentrations and may result in sub-optimal levels of tipranavir and lead to loss of virologic response and possible resistance to tipranavir.
Croatian: Očekuje se da istodobna primjena gospine trave znatno smanjuje koncentracije tipranavira i ritonavira te može rezultirati nedostatnim koncentracijama tipranavira i dovesti do gubitka virusnog odgovora i moguće otpornosti na tipranavir.
English: Steady-state tipranavir/r Digoxin Cmax ↓ 38% Digoxin AUC ↔
Croatian: Tipranavir/r u stanju ravnoteže Digoksin Cmax ↓ 38% Digoksin AUC ↔
English: No tipranavir with ritonavir dose adjustment is required.
Croatian: Nije potrebno podešavanje doze kombinacije tipranavira s ritonavirom.
English: In such cases no dosage adjustment of abacavir can be recommended (see section
Croatian: U takvom slučaju, ne treba prilagođavati dozu abakavira (vidjeti dio 4.4).
English: During HIV therapy there may be an increase in weight and in levels of blood lipids and glucose.
Croatian: Tijekom antiretrovirusne terapije mogu se povećati tjelesna težina i povisiti razine lipida i glukoze u krvi (vidjeti dio 4.4).
English: The following medicines are not recommended: - fluticasone (used to treat asthma) - atorvastatin (used to lower blood cholesterol) - salmeterol (used to achieve long-term asthma control, bronchospasm prevention with COPD) - bosentan (used to treat pulmonary artery hypertension) - halofantrine or lumefantrine (used to treat malaria) - tolterodine (used to treat overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence)) - boceprevir and telaprevir (used to treat hepatitis C) - cobicistat and products containing cobicistat (used to increase effectiveness of HIV medicines).
Croatian: Ne preporučuju se sljedeći lijekovi: - flutikazon (primjenjuje se u liječenju astme) - atorvastatin (primjenjuje se za snižavanje kolesterola u krvi) - salmeterol (primjenjuje se za postizanje dugotrajne kontrole astme, prevenciju bronhospazma u kroničnoj opstruktivnoj bolesti pluća) - bosentan (primjenjuje se u liječenju plućne hipertenzije) - halofantrin ili lumefantrin (primjenjuju se u liječenju malarije) - tolterodin (primjenjuje se u liječenju preaktivnog mjehura (sa simptomima učestalog mokrenja,
English: Carbamazepine total* Cmax ↑ 13% Carbamazepine total* AUC ↑ 16% Carbamazepine total* Cmin ↑ 23%
Croatian: Antiepileptici Karbamazepin 200 mg BID Karbamazepin ukupni* Cmax ↑ 13% Karbamazepin ukupni* AUC ↑ 16% Karbamazepin ukupni * Cmin ↑ 23%
English: Therefore, the co-administration of tipranavir, co-administered with low dose ritonavir, with protease inhibitors is not recommended.
Croatian: Stoga se ne preporučuje istodobna primjena tipranavira s niskom dozom ritonavira, i inhibitora proteaze.
English: Combination of rifampicin with Aptivus with concomitant low dose ritonavir is contraindicated (see section 4.5).
Croatian: Kombinacija rifampicina s Aptivusom i niskom dozom ritonavira je kontraindicirana (vidjeti dio 4.5).
English: Steady-state tipranavir/r Digoxin Cmax ↓ 20% Digoxin AUC ↔
Croatian: Tipranavir/r u stanju ravnoteže Digoksin Cmax ↓ 20% Digoksin AUC ↔
English: Macrogol
Croatian: Ergotamin
English: Co-administration of Aptivus, coadministered with low dose ritonavir, and pravastatin should be initiated with the lowest dose (10 mg/day) of pravastatin, titrated to treatment response, and accompanied with careful clinical monitoring for pravastatin associated symptoms as described in the label of pravastatin.
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i pravastatina počinje s najnižom dozom (10 mg/dan) pravastatina, titriranom do terapijskog odgovora, te uz pažljivo kliničko praćenje radi nuspojava pravastatina.
English: Co-administration of atorvastatin and Aptivus, co-administered with low dose ritonavir, is not recommended.
Croatian: Istodobna primjena atorvastatina i Aptivusa s niskom dozom ritonavira se ne preporučuje.
English: Increased monitoring (i.e. prior to initiation of therapy, every two weeks during the first three months of treatment, then monthly until 48 weeks, and then every eight to twelve weeks thereafter) is warranted when Aptivus and low dose ritonavir are administered to patients with elevated ASAT and ALAT levels, mild hepatic impairment, chronic hepatitis B or C, or other underlying liver disease.
Croatian: U bolesnika s povišenim vrijednostima AST/ALT, blagim oštećenjem jetre, kroničnim hepatitisom B ili C, ili drugom bolešću jetre, praćenje jetrene funkcije mora biti pojačano (tj. prije početka liječenja, svaka dva tjedna tijekom prva tri mjeseca liječenja, zatim jednom mjesečno do 48 tjedana, i nakon toga svakih osam do dvanaest tjedana).
English: Inhibition of CYP 2D6 by tipranavir/r
Croatian: Inhibicija CYP 2D6 putem tipranavira/r
English: Zidovudine Cmax ↓ 49% Zidovudine AUC ↓ 36%
Croatian: Zidovudin Cmax ↓ 49% Zidovudin AUC ↓ 36%
English: If the combination is nevertheless considered necessary, a monitoring of the plasma levels of amprenavir is strongly encouraged (see section
Croatian: Ako se ta kombinacija ipak smatra potrebnom, valja pratiti vrijednosti amprenavira u plazmi (vidjeti dio
English: Induction of CYP 1A2 by tipranavir/r
Croatian: Indukcija CYP 1A2 tipranavirom/r
English: Through 48 weeks of treatment, the proportion of patients in the tipranavir with ritonavir arm compared to the comparator PI/ritonavir arm with HIV-1 RNA < 400 copies/ml was 30% and 14% respectively, and with HIV-1 RNA < 50 copies/ml was 23% and 10% respectively.
Croatian: IP/ritonavir skupinu 14% dok je udio bolesnika s HIV-1 RNA <50 kopija/ml iznosio 23% za ispitivanu i 10% za kontrolnu skupinu.
English: Rash consists of one or more of the preferred terms of rash, drug eruption, rash macular, rash papular, erythema, rash maculo-papular, rash pruritic, and urticaria.
Croatian: Jedan ili više preferiranih termina: osip, medikamentozna erupcija, makularni osip, papularni osip, eritem, makulopapularni osip, pruritički osip ili urtikarija.
English: Concomitant use of Aptivus, coadministered with low dose ritonavir, and rifampicin is contraindicated (see section 4.3).
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i rifampicina je kontraindicirana (vidjeti dio 4.3).
English: Rash gamma GT increased ALAT increased
Croatian: Povišeni gama- GT Povišeni ALT Anemija
English: - omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole (proton pump inhibitors used to reduce the gastric acid production) - metronidazole (used to treat infections) - disulfiram (used to treat alcohol dependence) - buprenorphine/naloxone (medicines used to treat severe pain) - cyclosporin, tacrolimus, sirolimus (used to prevent organ rejection (to suppress the immune system)) - warfarin (used to treat and prevent thrombosis) - digoxin (used to treat heart arrhythmias and heart failure) - antifungal medications including fluconazole, itraconazole, ketoconazole or voriconazole
Croatian: Ne smije Vam se propisati tadalafil dok ne prođe 7 ili više dana od početka uzimanja Aptivusa. - omeprazol, esomeprazol, lanzoprazol, pantoprazol, rabeprazol (inhibitori protonske pumpe koji se primjenjuju za smanjenje proizvodnje želučane kiseline) - metronidazol (primjenuje se u liječenju infekcija) - disulfiram (primjenjuje se u liječenju ovisnosti o alkoholu) - buprenorfin/nalokson (lijekovi koji se primjenjuju za liječenje teške boli) - ciklosporin, takrolimus, sirolimus (primjenjuju se za sprječavanje odbacivanja organa (za supresiju imunološkog sustava)) - varfarin (primjenjuje se u liječenju i prevenciji tromboze) - digoksin (primjenjuje se u liječenju srčanih aritmija i zatajenja srca) - lijekovi za liječenje gljivičnih infekcija uključujući flukonazol, itrakonazol, ketokonazol ili vorikonazol
English: A safe and effective dose has not been established when used with Aptivus, co-administered with low dose ritonavir.
Croatian: Sigurna i učinkovita doza tadalafila kada se primjenjuje s Aptivusom uz nisku dozu ritonavira nije utvrđena.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function if treatment with Aptivus/ritonavir is required (see section 4.4).
Croatian: Preporučuje se sniženje doze kolhicina ili prekid liječenja kolhicinom za bolesnike s urednom funkcijom bubrega ili jetre u slučaju potrebe liječenja
English: Always take this medicine in combination with other antiretroviral medicines.
Croatian: Uvijek ćete morati uzimati Aptivus u kombinaciji s drugim antiretrovirusnim lijekovima.
English: Skin and subcutaneous tissue disorders common rash uncommon pruritus, exanthem
Croatian: Poremećaji kože i potkožnog tkiva često osip manje često pruritus, egzantem
English: Increasing baseline phenotypic fold change to tipranavir in isolates is correlated to decreasing virological response.
Croatian: Viša razina fenotipske otpornosti na tipranavir ustanovljena prije početka liječenja združena je s nižom stopom virološkog odgovora.
English: Further dosage reduction may be necessary.
Croatian: Dozu rifabutina može biti potrebno dodatno sniziti.
English: These occur particularly when Aptivus or other protease inhibitors are taken together with nucleoside analogues.
Croatian: Prijavljeni su slučajevi bolova u mišićima, osjetljivosti ili slabosti, koji se pojavljuju osobito kad se Aptivus ili drugi inhibitori uzimaju zajedno s nukleozidnim analozima.
English: Dyspepsia
Croatian: Propafenon
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with pimozide, sertindole, quetiapine or lurasidone is contraindicated due to potential serious and/or life threatening events, including coma (see section
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i pimozida, sertindola, kvetiapina ili lurasidona je kontraindicirana zbog potencijalnih teških i/ili fatalnih događaja, uključujući komu (vidjeti dio 4.3)
English: The clinical relevance of this reduction in saquinavir concentrations has not been established.
Croatian: Klinički značaj ovog smanjenja koncentracija sakvinavira nije utvrđen.
English: The clinical relevance of this reduction in lopinavir concentrations has not been established.
Croatian: Klinički značaj ovog smanjenja koncentracija lopinavira nije utvrđen.
English: Based on theoretical considerations, tipranavir, co-administered with low dose ritonavir, is expected to increase pimozide, sertindole, quetiapine and lurasidone concentrations.
Croatian: Temeljem teoretskih razmatranja, očekuje se da tipranavir u primjeni s niskom dozom ritonavira, povećava koncentracije pimozida, sertindola, kvetiapina i lurasidona.
English: RESIST-1 and RESIST-2 are ongoing, randomised, open-label, multicentre studies in HIV-positive, triple-class experienced patients, evaluating treatment with 500 mg tipranavir co-administered with low dose ritonavir (200 mg; twice daily) plus an optimised background regimen (OBR) individually defined for each patient based on genotypic resistance testing and patient history.
Croatian: Ocjenjivani su učinci 500 mg tipranavira s niskom dozom ritonavira (200 mg; dvaput dnevno) dodanih na osnovni optimizirani režim (optimized background regimen, OBR) koji je individualno određen za svakog bolesnika temeljem genotipskog testiranja rezistencije virusa i anamneze bolesnika.
English: Concomitant use of salmeterol and Aptivus, co-administered with low dose ritonavir, is not recommended (see section 4.5).
Croatian: Salmeterol Istodobna primjena salmeterola i Aptivusa s niskom dozom ritonavira se ne preporuča (vidjeti dio 4.5).
English: Grade 3 or 4 elevations of triglycerides occurred more frequently in the tipranavir with ritonavir arm compared with the comparator arm. At 48 weeks these rates were 25.2% of patients in the tipranavir with ritonavir arm and 15.6% in the comparator arm.
Croatian: Nakon 48 tjedana ove stope su bile 25,2% bolesnika na režimu tipranavir s ritonavirom te 15,6% u komparatorskom režimu.
English: A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE Name and address of the manufacturer responsible for batch release Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Strasse 173, D-55216 Ingelheim am Rhein, Germany.
Croatian: Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet Boehringer Ingelheim Pharma GmbH & Co.
English: - Abnormal liver function - Hepatitis and fatty liver - Liver failure.
Croatian: - Abnormalna funkcija jetre - hepatitis i masna jetra - zatajenje jetre, što može dovesti do smrti - povišene vrijednosti bilirubina u krvi (razgradni produkt hemoglobina)
English: Tipranavir, co-administered with low dose ritonavir, is expected to increase desipramine concentrations
Croatian: Očekuje se da tipranavir u primjeni s niskom dozom ritonavira povećava koncentracije dezipramina.
English: Based on theoretical considerations, tipranavir, co-administered with low dose ritonavir, is expected to increase halofantrine and lumefantrine concentrations.
Croatian: Temeljem teoretskih razmatranja, očekuje se da tipranavir u primjeni s niskom dozom ritonavira povećava koncentracije halofantrina i lumefantrina.
English: Combination with Aptivus, coadministered with low dose ritonavir, is not recommended (see section 4.4)
Croatian: Kombinacija s Aptivusom s niskom dozom ritonavira se ne preporučuje (vidjeti dio 4.4)
English: Based on theoretical considerations, tipranavir, co-administered with low dose ritonavir, is expected to increase astemizole and terfenadine concentrations.
Croatian: Temeljem teoretskih razmatranja, očekuje se da tipranavir s niskom dozom ritonavira povećava koncentracije astemizola i terfenadina.
English: Concomitant use of Aptivus, coadministered with low dose ritonavir, and oral midazolam is contra-indicated (see section 4.3).
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i oralnog midazolama je kontraindicirana (vidjeti dio 4.3).
English: CYP 3A4 inhibition and induction by tipranavir/r
Croatian: CYP 3A4 inhibicija i indukcija putem tipranavira/r
English: Fusion inhibitors Enfuvirtide No interaction study
Croatian: Inhibitori fuzije Enfuvirtid
English: If the combination is nevertheless considered necessary, a monitoring of the plasma levels of lopinavir is strongly encouraged (see section
Croatian: Ako se ta kombinacija ipak smatra potrebnom, valja pratiti vrijednosti lopinavira u plazmi (vidjeti dio 4.4).
English: In patients with renal or hepatic impairment, co-administration of colchicine in patients on Aptivus/ritonavir is contraindicated (see section 4.3).
Croatian: U bolesnika s oštećenjem bubrega ili jetre koji primaju Aptivus/ritonavir, istodobna primjena kolhicina je kontraindicirana (vidjeti dio 4.3).
English: This can lead to death - Increased blood levels of bilirubin (a breakdown product of haemoglobin) You should inform your child's doctor if they experience: - Loss of appetite - Nausea (upset stomach) - Vomiting and/or jaundice which may be symptoms of abnormal liver function - Bleeding - * Bleeding in the brain.
Croatian: Potrebno je obavijestiti djetetovog liječnika ako Vaše dijete ima: - gubitak apetita - mučninu - povraćanje i/ili žuticu koji mogu biti simptomi abnormalne funkcije jetre - Krvarenje - * krvarenje u mozgu, koje može dovesti do trajnog invaliditeta ili smrti, a pojavilo se u nekih bolesnika koji su se liječili Aptivusom u kliničkim ispitivanjima.
English: Coadministration of telaprevir with Aptivus/ritonavir is not recommended.
Croatian: Istodobna primjena telaprevira s Aptivusom/ritonavirom se ne preporučuje.
English: Abdominal pain
Croatian: Bol u abdomenu Osip
English: The concomitant use of Aptivus, coadministered with low dose ritonavir, with atazanavir/ritonavir is not recommended.
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i atazanavira/ritonavira se ne preporučuje.
English: If the combination is nevertheless considered necessary, a monitoring of the plasma levels of saquinavir is strongly encouraged (see section
Croatian: Ako se ta kombinacija ipak smatra potrebnom, valja pratiti vrijednosti sakvinavira u plazmi (vidjeti dio
English: Inhibition of CYP 3A4 by tipranavir/r.
Croatian: Inhibicija CYP 3A4 putem tipranavira/r.
English: CYP 3A4 inhibition by tipranavir/r
Croatian: CYP 3A4 inhibicija putem tipranavira/r
English: Abacavir 300 mg BID (TPV/r 750/100 mg BID)
Croatian: Abakavir 300 mg BID (TPV/r 750/100 mg BID)
English: Coadministration of boceprevir with Aptivus/ritonavir is not recommended.
Croatian: Istodobna primjena boceprevira s Aptivusom/ritonavirom se ne preporučuje.
English: Based on theoretical considerations, tipranavir, co-administered with low dose ritonavir, is expected to increase flecainide, propafenone and metoprolol concentrations.
Croatian: Temeljem teoretskih razmatranja, očekuje se da tipranavir u primjeni s niskom dozom ritonavira povećava koncentracije flekainida, propafenona i metoprolola.
English: H2-receptor antagonists No interaction study performed
Croatian: Antagonisti H2-receptora
English: Mono/diglycerides of caprylic/capric acid Propylene glycol
Croatian: Sadržaj kapsule makrogolglicerolricinoleat etanol mono/digliceridi kaprilatne/kaprinske kiseline propilenglikol pročišćena voda trometamol propilgalat
English: - omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole (proton pump inhibitors used to reduce the gastric acid production) - metronidazole (used to treat infections) - disulfiram (used to treat alcohol dependence) - buprenorphine/naloxone (medicines used to treat severe pain) - cyclosporin, tacrolimus, sirolimus (used to prevent organ rejection (to suppress the immune system)) - warfarin (used to treat and prevent thrombosis)
Croatian: Ne smije se propisivati tadalafil dok ne prođe 7 ili više dana od početka primjene Aptivusa. - omeprazol, esomeprazol, lanzoprazol, pantoprazol, rabeprazol (inhibitori protonske pumpe koji se primjenjuju za smanjenje proizvodnje želučane kiseline) - metronidazol (primjenjuje se u liječenju infekcija) - disulfiram (primjenjuje se u liječenju ovisnosti o alkoholu) - buprenorfin/nalokson (lijekovi koji se primjenjuju u liječenje teške boli) - ciklosporin, takrolimus, sirolimus (primjenjuju se za sprječavanje odbacivanja organa (za supresiju imunološkog sustava)) - varfarin (primjenjuje se u liječenju i prevenciji tromboze) - digoksin (primjenjuje se u liječenju srčanih aritmija i zatajenja srca)
English: If a dose is missed by more than 5 hours, the patient should be instructed to wait and then to take the next dose of Aptivus and ritonavir at the regularly scheduled time.
Croatian: U slučaju propuštanja doze za više od 5 sati, bolesnika je potrebno uputiti da pričeka na uzimanje sljedeće doze Aptivusa i ritonavira u redovno vrijeme prema režimu doziranja.
English: Antithrombotics Warfarin 10 mg QD First-dose tipranavir /r: S-warfarin Cmax ↔ S-warfarin AUC ↑ 18%
Croatian: Prva doza tipranavira/r: S-varfarin Cmax ↔ S-varfarin AUC ↑ 18%
English: The concomitant use of Aptivus, co-administered with low dose ritonavir, with astemizole or terfenadine is contraindicated due to potential serious and/or life threatening events (see section 4.3)
Croatian: Istodobna primjena Aptivusa s niskom dozom ritonavira i astemizola ili terfenadina je kontraindicirana zbog potencijalnih teških i/ili fatalnih događaja (vidjeti dio 4.3)
English: Anticonvulsants Carbamazepine 200 mg BID
Croatian: Antitrombotici Varfarin 10 mg QD
English: Co-administration of bosentan and Aptivus with low dose ritonavir is not recommended (see section 4.4).
Croatian: Istodobna primjena bosentana i Aptivusa s niskom dozom ritonavira se ne preporučuje (vidjeti dio 4.4)
English: Baseline CD4+ (cells/mm
Croatian: Medijan promjene od početnog broja CD4+ stanica (stanice/mm