FrancophonIA/ELRC3.0 huggingface dataset:
English: Intake of strontium ranelate with calcium or food reduces the bioavailability of strontium by approximately 60-70%, compared with administration 3 hours after a meal.
Croatian: Uzimanjem stroncijeva ranelata s kalcijem ili s hranom smanjuje se bioraspoloživost stroncija za oko 60-70 % u usporedbi s primjenom 3 sata nakon jela.
English: Statistically significant increases in BMD were observed as early as 6 months following initiation of OSSEOR treatment versus placebo.
Croatian: Povećanje BMD-a bilo je statistički značajno već 6 mjeseci nakon početka uzimanja OSSEOR-a u usporedbi s placebom.
English: The recommended dose is one 2g sachet a day.
Croatian: Preporučena doza je jedna vrećica od 2 g na dan.
English: If you are unsure about this ask your doctor or pharmacist.
Croatian: Ako u svezi toga niste sigurni, upitajte svog liječnika ili ljekarnika.
English: Patients treated with strontium ranelate should receive vitamin D and calcium supplements if dietary intake is inadequate.
Croatian: Bolesnici koji uzimaju stroncijev ranelat trebaju primati i nadopunu vitamina D i kalcija, ako unos tih tvari hranom nije dovoljan.
English: Its plasma clearance is about 12 ml/min (CV 22%) and its renal clearance about 7 ml/min (CV 28%).
Croatian: ml/min (CV 22 %), a bubrežni klirens je oko 7 ml/min (CV 28 %).
English: Discontinuation of therapy was mainly due to nausea (1.3% and 2.2% in the placebo and strontium ranelate groups respectively).
Croatian: Terapija je prekidana uglavnom zbog mučnine (1,3% u skupini koja je uzimala placebo i 2,2 % u skupini koja je uzimala stroncijev ranelat).
English: Stevens-Johnson syndrome and toxic epidermal necrolysis appear initially as reddish target-like spots or circular patches often with central blisters on the trunk.
Croatian: Stevens-Johnson-ov sindrom i toksična epidermalna nekroliza započinju pojavom crvenih pjega poput mete ili kružnih mrlja često sa mjehurićem u sredini na trupu.
English: Strontium excretion occurs via the kidneys and the gastrointestinal tract.
Croatian: Stroncij se izlučuje putem bubrega i gastrointestinalnog sustava.
English: Aspartame (E951)
Croatian: Također sadrži aspartam (E951).
English: • OSSEOR is only indicated for use in patients with severe osteoporosis at high risk of fracture, for whom treatment with other medicinal products approved for the treatment of osteoporosis is not possible due to, for example, contraindications or intolerance.
Croatian: • OSSEOR je indiciran samo za primjenu u bolesnika s teškom osteoporozom s visokim rizikom za nastanak prijeloma, kod kojih liječenje s drugim lijekovima odobrenima za liječenje osteoporoze nije moguće zbog, na primjer, kontraindikacija ili nepodnošenja.
English: • The contraindications to the treatment with OSSEOR.
Croatian: • Kontraindikacije za primjenu OSSEOR-a.
English: Secondary to the pharmacological effects of strontium ranelate, slight decreases in calcium and parathyroid hormone (PTH) serum concentrations, increases in blood phosphorus concentrations and in total alkaline phosphatase activity were observed, with no observed clinical consequences.
Croatian: Kao posljedica farmakološkog učinka stroncijeva ranelata, uočeno je blago smanjenje serumskih koncentracija kalcija i paratireoidnog hormona (PTH) te porast koncentracija fosfora i ukupne aktivnosti alkalne fosfataze u krvi, no bez vidljivih kliničkih posljedica.
English: Long-term safety has been evaluated in postmenopausal women with osteoporosis treated for up to 60 months with strontium ranelate 2 g/day (n=3,352) or placebo (n=3,317) in phase III studies.
Croatian: Dugoročna sigurnost ocjenjivana je u ispitivanjima III. faze u žena s osteoporozom u poslijemenopauzi, koje su stroncijev ranelat u dozi od 2 g/dan (n=3352) ili placebo (n=3317) uzimale u trajanju sve do 60 mjeseci.
English: These included: nonsteroidal anti-inflammatory agents (including acetylsalicylic acid), anilides (such as paracetamol), H2 blockers and proton pump inhibitors, diuretics, digoxin and cardiac glycosides, organic nitrates and other vasodilators for cardiac diseases, calcium channel blockers, beta blockers, ACE inhibitors, angiotensin II antagonists, selective beta-2 adrenoceptor agonists, oral anticoagulants, platelet aggregation inhibitors, statins, fibrates and benzodiazepine derivatives.
Croatian: Među te se lijekove ubrajaju: nesteroidni protuupalni lijekovi (uključivši acetilsalicilnu kiselinu), anilidi (npr. paracetamol), H2-blokatori i inhibitori protonske pumpe, diuretici, digoksin i kardijalni glikozidi, organski nitrati i ostali vazodilatatori za srčane bolesti, blokatori kalcijevih kanala, beta-blokatori, ACE inhibitori, antagonisti angiotenzina II, selektivni agonisti beta-2-adrenoreceptora, peroralni antikoagulansi, inhibitori agregacije trombocita, statini, fibrati i derivati benzodiazepina.
English: o As soon as possible in the event of an illness or a condition leading to immobilization, the treatment should be discontinued.
Croatian: U slučaju bolesti ili stanja koja dovodi do imobilizacije, liječenje treba što je moguće prije prekinuti.
English: In phase III placebo-controlled studies, strontium ranelate treatment was associated with an increase in the annual incidence of venous thromboembolism (VTE), including pulmonary embolism (see section 4.8).
Croatian: U placebom kontroliranim istraživanjima III. faze, terapija stroncijevim ranelatom bila je povezana s godišnjim porastom incidencije venske tromboembolije (VTE), uključivši plućnu emboliju (vidjeti dio 4.8).
English: It is recommended that you take OSSEOR at bedtime, preferably at least 2 hours after dinner.
Croatian: Preporučuje se OSSEOR uzimati u vrijeme odlaska na spavanje, barem 2 sata nakon večere.
English: Administration of milk or antacids may be helpful to reduce the absorption of the active substance.
Croatian: Primjena mlijeka ili antacida može pomoći u smanjenju apsorpcije djelatne tvari.
English: In phase III studies, 85% of the patients had a creatinine clearance between 30 and 70 ml/min and 6% below 30 ml/min at inclusion, and the mean creatinine clearance was about 50 ml/min.
Croatian: U ispitivanjima III. faze klirens kreatinina u 85 % ispitanika bio je između 30 i 70 ml/min, a u njih 6 % bio je manji od 30 ml/min na početku ispitivanja i srednji klirens kreatinina iznosio je oko 50 ml/min.
English: DRESS appears initially as flu-like symptoms and a rash on the face then an extended rash with a high temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes.
Croatian: DRESS započinje simptomima sličnim gripi i osipom na licu koji se širi, praćen visokom temperaturom, povišenim razinama jetrenih enzima u krvi i povećanim brojem određene vrste bijelih krvnih stanica (eozinofilija), te povećanim limfnim čvorovima.
English: In this group, over 3 years of treatment, OSSEOR reduced the risk of hip fracture by 36% relative to the placebo group (table 2).
Croatian: U te je skupine OSSEOR tijekom 3 godine liječenja smanjio rizik od prijeloma bedrene kosti za 36 % u usporedbi sa skupinom koja je uzimala placebo (Tablica 2).
English: Strontium interferes with colorimetric methods for the determination of blood and urinary calcium concentrations.
Croatian: Stroncij ometa određivanje koncentracija kalcija u krvi i urinu kolorimetrijskim metodama.
English: Table 1: Incidence of patients with vertebral fracture and relative risk reduction Placebo
Croatian: Tablica 1: Incidencija prijeloma vratne kralješnice i smanjenje relativnog rizika
English: Table 2: Incidence of patients with hip fracture and relative risk reduction in patients with BMD ≤ -2.4 SD (NHANES III) and age ≥ 74 years
Croatian: Tablica 2. Incidencija prijeloma kuka i smanjenje relativnog rizika u ispitanica s BMD ≤ -2,4 SD (NHANES III) u dobi ≥ 74 godine
English: Maximum plasma concentrations are reached 3-5 hours after a single dose of 2 g. Steady state is reached after 2 weeks of treatment.
Croatian: Maksimalne se koncentracije u plazmi postižu 3-5 sati nakon primjene jednokratne doze od 2 g.
English: Pregnancy and breast-feeding:
Croatian: Trudnoća i dojenje:
English: There are no data in patients to demonstrate elimination kinetics of strontium from bone off-therapy.
Croatian: Nema podataka o kinetici eliminacije stroncija iz kosti bolesnika nakon okončanja terapije.
English: Overall incidence rates for adverse reactions with strontium ranelate did not differ from placebo and adverse reactions were usually mild and transient.
Croatian: Sveukupne stope incidencije nuspojava pri uzimanju stroncijeva ranelata nisu se razlikovale od onih pri uzimanju placeba, a nuspojave su obično bile blage i prolazne.
English: Established, current or past history of ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
Croatian: Dokazana, postojeća ili prethodna ishemijska bolest srca, periferna arterijska bolest i/ili cerebrovaskularna bolest u anamnezi.
English: In bone tissue of treated animals and humans, strontium is mainly adsorbed onto the crystal surface and only slightly substitutes for calcium in the apatite crystal of newly formed bone.
Croatian: U koštanom tkivu životinja i ljudi koji su primali lijek, stroncij se pretežno adsorbirao na površinu kristala i samo neznatno nadomještao kalcij u apatitnim kristalima novostvorene kosti.
English: In phase III studies, as compared to placebo, biochemical markers of bone formation (bone-specific alkaline phosphatase and C-terminal propeptide of type I procollagen) increased and those of bone resorption (serum C-telopeptide and urinary N-telopeptide cross links) decreased from the third month of treatment up to 3 years.
Croatian: faze vrijednosti biokemijskih pokazatelja stvaranja kosti (alkalna fosfataza specifična za koštano tkivo i C-terminalni propeptid prokolagena tipa I) su porasle, a vrijednosti pokazatelja resorpcije kosti (serumski C-telopeptid i urinarni N-telopeptid poprečno vezan) su se smanjile u usporedbi s placebom, počevši od trećeg mjeseca do 3 godine liječenja.
English: Nausea, diarrhoea, headache, skin irritation, memory troubles, fainting fit.
Croatian: Mučnina, proljev, glavobolja, nadražaj kože, poteškoće s pamćenjem, nesvjestica.
English: No interaction was observed with oral supplementation of vitamin D.
Croatian: Nije uočena interakcija s nadopunama vitamina
English: PHARMACEUTICAL FORM Granules for oral suspension Yellow granules
Croatian: OBLIK Granule za oralnu suspenziju Žute granule
English: Treatment of severe osteoporosis:
Croatian: Liječenje teške osteoporoze:
English: OSSEOR works by reducing bone breakdown and stimulating rebuilding of bone and therefore reduces the risk of fracture.
Croatian: OSSEOR djeluje tako da usporava razgradnju, a pospješuje ponovnu izgradnju kosti čime se smanjuje opasnost od prijeloma.
English: These effects were reported at bone strontium levels 2-3 times higher than bone strontium levels in humans up to 3 years of treatment.
Croatian: Ti učinci uočeni su pri koncentracijama stroncija u kosti koje su bile 2-3 puta veće od onih uočenih pri trogodišnjem liječenju u ljudi.
English: The following adverse reactions have been reported during clinical studies and/or post marketing use with Strontium ranelate.Adverse reactions, defined as adverse events considered at least possibly attributable to strontium ranelate treatment in phase III studies are listed below using the following convention (frequencies versus placebo): very common (>1/10); common (>1/100, <1/10); uncommon (>1/1,000, <1/100); rare (>1/10,000, <1/1,000); very rare (<1/10,000) ; not known (cannot be estimated from the available data).
Croatian: faze bili barem moguće povezani s liječenjem stroncijevim ranelatom, navedene su niže i prema učestalosti razvrstane su na sljedeći način (učestalost u odnosu na placebo): vrlo često (>1/10); često (>1/100, <1/10); manje često (>1/1000, <1/100); rijetko (>1/10 000, <1/1000); vrlo rijetko (<1/10 000); nepoznato (učestalost se ne može procijeniti iz dostupnih podataka).
English: However, osteoporosis makes you more likely to have fractures (break bones), especially in your spine, hips and wrists.
Croatian: No osteoporoza povećava sklonost prijelomima kostiju (frakturama), osobito prijelomima kralješnice, kukova i zapešća
English: Temporary or permanent immobilisation due to e.g. post-surgical recovery or prolonged bed rest.
Croatian: Privremena ili trajna imobilizacija zbog npr. oporavka poslije operacije ili produljenog mirovanja u krevetu.
English: Measurement of strontium concentration in iliac crest bone biopsies from patients treated for up to 60 months with strontium ranelate 2 g/day indicate that bone strontium concentrations may reach a plateau after about 3 years of treatment.
Croatian: Mjerenja koncentracije stroncija u biopsijskom materijalu iz kriste ilijake bolesnika koji su do 60 mjeseci uzimali stroncijev ranelat u dozi od 2 g/dan pokazuju da koncentracija stroncija u kosti vjerojatno doseže plato nakon otprilike 3 godine terapije.
English: OSSEOR also decreased the number of patients with a body height loss of at least 1 cm as compared to placebo.
Croatian: OSSEOR je, u usporedbi s placebom, smanjio i broj bolesnica čija se visina tijela smanjila za više od 1 cm.
English: Strontium ranelate does not modify the bone crystal characteristics.
Croatian: Stroncijev ranelat ne mijenja obilježja koštanih kristala.
English: - If you are taking medicines containing calcium, you should leave at least 2 hours before you take OSSEOR.
Croatian: - Uzimate li lijekove koji sadržavaju kalcij, OSSEOR smijete uzeti tek nakon što prođu najmanje dva sata od uzimanja tih lijekova.
English: Marketing Authorisation Holder Les Laboratoires Servier 50, rue Carnot
Croatian: LES LABORATOIRES SERVIER 50, rue Carnot
English: Due to its high polarity, the absorption, distribution and binding to plasma proteins of ranelic acid are low.
Croatian: Zbog svoje velike polarnosti, ranelatna se kiselina slabo apsorbira, slabo distribuira i slabo veže na proteine plazme.
English: - in adult men, at high risk of fracture, for whom treatment with other medicinal products approved for the treatment of osteoporosis is not possible due to, for example, contraindications or intolerance.
Croatian: - u žena u poslijemenopauzi - u odraslih muškaraca s visokim rizikom za nastanak prijeloma, kod kojih liječenje s drugim lijekovima odobrenima za liječenje osteoporoze nije moguće zbog, na primjer, kontraindikacija ili nepodnošenja.
English: There is no pharmacokinetic data in patients with hepatic impairment.
Croatian: Nema farmakokinetičkih podataka za osobe s oštećenom funkcijom jetre.
English: The best results in managing SJS, TEN or DRESS come from early diagnosis and immediate discontinuation of any suspect drug.
Croatian: Najbolji rezultati liječenja SJS, TEN ili DRESS su postignuti u slučajevima rane dijagnoze i trenutnog prekida primjene svakog lijeka na koji se sumnja da je uzrokovao reakciju.
English: PHARMACEUTICAL FORM AND CONTENTS Granules for oral suspension.
Croatian: OBLIK I SADRŽAJ Granule za oralnu suspenziju.
English: Together, SOTI and TROPOS enrolled 1,556 patients over 80 years at inclusion (23.1% of the study population).
Croatian: sudjelovalo je 1556 bolesnica starijih od 80 godina pri uključivanju u ispitivanju (23,1 % populacije iz ispitivanja).
English: In phase III studies, which demonstrated the anti-fracture efficacy of OSSEOR treatment, measured mean BMD increased from baseline with OSSEOR by approximately 4% per year at the lumbar spine and 2% per year at the femoral neck, reaching 13% to 15% and 5% to 6% respectively after 3 years, depending on the study.
Croatian: U ispitivanjima III. faze, kojima je dokazana djelotvornost OSSEOR -a u sprječavanju prijeloma, izmjerena BMD povećavala se pri uzimanju OSSEOR -a u odnosu na početnu vrijednost za oko 4 % godišnje u slabinskim kralješcima i oko 2 % godišnje u vratu bedrene kosti te se do kraja istraživanja, nakon 3 godine, ovisno o istraživanju, povećala za ukupno 13 % do 15 %,
English: Strontium ranelate is not recommended for patients with severe renal impairment (creatinine clearance below 30 ml/min) (see sections 4.4 and 5.2).
Croatian: Stroncijev se ranelat ne preporučuje bolesnicima s teško oštećenom funkcijom bubrega (klirens kreatinina manji od 30 ml/min) (vidjeti dijelove 4.4 i 5.2).
English: • OSSEOR should only be used with caution in: o Patients with significant risk factors for cardiovascular events such as hypertension, hyperlipidaemia, diabetes mellitus or smoking.
Croatian: o Bolesnika sa značajnim čimbenicima rizika za nastanak kardiovaskularnih događaja kao što su hipertenzija, hiperlipidemija, diabetes mellitus ili pušenje.
English: There is no pharmacokinetic data in patients with severe renal impairment (creatinine clearance below 30 ml/min).
Croatian: Nema farmakokinetičkih podataka za osobe s teško oštećenom funkcijom bubrega (klirens kreatinina manji od 30 ml/min).
English: The efficacy of OSSEOR was demonstrated in men with osteoporosis in a 2-year, double-blind, placebo-controlled study with a main analysis after one year in 243 patients (Intention to treat population, 161 patients received strontium ranelate) at high risk of fracture (mean age 72,7 years; mean lumbar BMD T-score value of -2.6; 28% of prevalent vertebral fracture).
Croatian: Djelotvornost OSSEOR-a je dokazana kod muškaraca s osteporozom u dvogodišnjem, dvostrukoslijepom, placebom kontroliranom ispitivanju s glavnom analizom provedenom nakon jedne godine na 243 ispitanika (ITT populacija, 161 ispitanik je primao stroncijev ranelat) s visokim rizikom od prijeloma (srednja dob 72,7 godina; srednja BMD T-vrijednost za lumbalnu kralježnicu -2,6%; prevalencija prijeloma kralježnice 28%).
English: No evidence of clinical interactions or relevant increase of blood strontium levels with medicinal products expected to be commonly prescribed concomitantly with OSSEOR in the target population were found during clinical trials.
Croatian: Tijekom kliničkih istraživanja nije bilo dokaza klinički značajnih interakcija, kao niti značajnog porasta razine stroncija u krvi pri istodobnom uzimanju lijekova za koje se očekivalo da će se u ciljne populacije često propisivati istodobno s OSSEOR-om.
English: • Patient alert card
Croatian: • Karticu s upozorenjima za bolesnike
English: Over 12 months, a statistically significant increase in mean lumbar spine BMD, main efficacy criteria (E (SE) = 5.32% (0.75); 95%CI = [3.86 ; 6.79]; p<0,001), similar to that observed in the pivotal antifracture phase III studies carried-out in postmenopausal women, was observed.
Croatian: Tijekom 12 mjeseci uočeno je statistički značajno povećanje BMD-a lumbalne kralježnice, glavnog kriterija djelotvornost (E (SE)=5,32% (0,75); 95%CI [3,86; 6,79]; p=0,001), je održano tijekom 12
English: The rash may progress to widespread blistering or peeling of the skin.
Croatian: Osip može napredovati do toga da su veća područja kože zahvaćena mjehurima ili ljuštenjem.
English: However, when this dosing regimen is impractical due to the recommended administration of OSSEOR at bedtime, concomitant intake remains acceptable.
Croatian: No kada takav način doziranja nije praktičan zbog preporuke da se OSSEOR uzima u vrijeme odlaska na počinak, prihvatljivo je uzeti oba lijeka istodobno.
English: If symptoms or signs of SJS or TEN (e.g. progressive skin rash often with blisters or mucosal lesions) or DRESS (e.g. rash, fever, eosinophilia and systemic involvement (e.g. adenopathy, hepatitis, interstitial nephropathy, interstitial lung disease) are present, OSSEOR treatment should be discontinued immediately.
Croatian: Ukoliko su prisutni simptomi ili znakovi SJS ili TEN (npr. progresivni kožni osip s mjehurićima ili mukoznim lezijama) ili DRESS (npr. osip, vrućica, eozinofilija i sustavni simptomi (npr. adenopatija, hepatitis, intersticijska nefropatija, intersticijska bolest pluća) treba odmah prekinuti primjenu
English: The combined effects of strontium distribution in bone (see section 5.2) and increased X-ray absorption of strontium as compared to calcium, leads to an amplification of bone mineral density (BMD) measurement by dual-photon X-ray absorptiometry (DXA).
Croatian: Zahvaljujući kombiniranom djelovanju raspodjele stroncija u kosti (vidjeti dio 5.2) i pojačane apsorpcije stroncija mjerene rendgenski, u usporedbi s kalcijem, povećava se mineralna gustoća kosti
English: In postmenopausal women, strontium ranelate reduces the risk of vertebral and hip fractures (see section
Croatian: Kod žena u poslijemenopauzi, stroncijev ranelat smanjuje rizik nastanka prijeloma kralježnice i kuka (vidjeti dio
English: EU/1/04/287/005/ 84 sachets (3 packs of 28) EU/1/04/287/006 100 sachets
Croatian: EU/1/04/287/004 56 vrećica EU/1/04/287/005 84 vrećica(3 pakiranja od 28 vrećica) EU/1/04/287/006 100 vrećica
English: Current or previous venous thromboembolic events (VTE), including deep vein thrombosis and pulmonary embolism.
Croatian: Postojeći ili prethodni događaji venske tromboembolije (VTE), uključujući duboku vensku trombozu i plućnu emboliju.
English: What OSSEOR is and what it is used for What you need to know before you take OSSEOR How to take OSSEOR
Croatian: Što morate znati prije nego počnete uzimati OSSEOR
English: Hip fracture over 3 years
Croatian: Prijelomi kuka tijekom 3 godine
English: The outcome of DRESS is favorable in most cases upon discontinuation of OSSEOR and after initiation of corticosteroid therapy when necessary.
Croatian: DRESS-a povoljan nakon prestanka primjene OSSEOR-a i nakon uvođenja liječenja kortikosteroidima kada je neophodno.
English: Do not take calcium supplements at bedtime, at the same time as OSSEOR.
Croatian: Nadopunu kalcija nemojte uzimati istodobno s OSSEOR-om u vrijeme odlaska na spavanje.
English: As strontium ranelate is not metabolised, no dose adjustment is required in patients with hepatic impairment.
Croatian: Budući da se stroncijev ranelat ne metabolizira, u osoba s oštećenom funkcijom jetre dozu ne treba prilagođavati.
English: The elimination of strontium is time and dose independent.
Croatian: Eliminacija Eliminacija stroncija ne ovisi ni o vremenu ni o dozi.
English: If you have developed Stevens-Johnson syndrome or toxic epidermal necrolysis or DRESS with the use of OSSEOR, you must not be re-started on OSSEOR at any time If you develop a rash or these skin symptoms, stop taking OSSEOR, seek urgent advice from a doctor and tell him that you are taking this medicine.
Croatian: Ukoliko ste razvili osip ili gore nabrojane kožne simptome prestanite uzimati OSSEOR, hitno zatražite savjet liječnika i recite mu da uzimate ovaj lijek.
English: In phase III studies, the annual incidence of venous thromboembolism (VTE) observed over 5 years was approximately 0.7%, with a relative risk of 1.4 (95% CI = [1.0 ; 2.0]) in strontium ranelate treated patients as compared to placebo (see section 4.4).
Croatian: faze godišnja incidencija venske tromboembolije (VTE), promatrana tijekom 5 godina, bila je oko 0,7 %, a relativni je rizik u bolesnika koji su uzimali stroncijev ranelat bio 1,4 (95% CI = [1,0; 2,0]) u usporedbi s onima koji su uzimali placebo (vidjeti dio 4.4).
English: Posology The recommended dose is one 2 g sachet once daily by oral administration.
Croatian: Preporučena dnevna doza je jedna vrećica od 2 g jedanput na dan peroralnom primjenom.
English: In patients with mild-to-moderate renal impairment (30-70 ml/min creatinine clearance), strontium clearance decreases as creatinine clearance decreases (approximately 30% decrease over the creatinine clearance range 30 to 70 ml/min) and thereby induces an increase in strontium plasma levels.
Croatian: klirens stroncija smanjuje se s klirensom kreatinina (oko 30 % smanjenja pri klirensu kreatinina u rasponu od 30 do 70 ml/min), zbog čega raste razina stroncija u plazmi.
English: As a divalent cation, strontium is not metabolised.
Croatian: Stroncij se, kao dvovalentni kation, ne metabolizira.
English: New vertebral fracture over the 1st year
Croatian: Novi prijelom kralješnice tijekom 1. godine