FrancophonIA/ELRC3.0 huggingface dataset:
English: The 1st click indicates that the injection has started.
Croatian: Prvi klik označava da je injekcija započela.
English: In a 2-year active-controlled study where patients were treated with either etanercept alone, methotrexate alone or etanercept in combination with methotrexate, the rates of serious infections were similar among the treatment groups.
Croatian: U dvogodišnjem aktivno kontroliranom ispitivanju u kojem su bolesnici liječeni samo etanerceptom, samo metotreksatom ili etanerceptom u kombinaciji s metotreksatom, stope ozbiljnih infekcija bile su slične za sve liječene skupine.
English: In the post-marketing setting, cases of leukaemia have been reported in patients treated with TNF-antagonists.
Croatian: U razdoblju nakon stavljanja lijeka u promet prijavljeni su slučajevi leukemije u bolesnika koji su liječeni antagonistima TNF-a.
English: Your doctor will determine if Erelzi is an appropriate treatment.
Croatian: Liječnik će odrediti je li liječenje Erelzijem primjereno za Vas.
English: If you forget to inject Erelzi
Croatian: Ako ste zaboravili primijeniti Erelzi
English: There was some evidence to support a benefit of re-treatment with etanercept in patients initially responding to treatment.
Croatian: Zabilježeni su dokazi koji podupiru korist ponovne primjene etanercepta u bolesnika koji su inicijalno odgovorili na liječenje.
English: Clean the injection site with an alcohol swab.
Croatian: Očistite mjesto primjene injekcije alkoholnim tupferom.
English: Keep the plunger fully depressed while you carefully lift the needle straight out from the injection site.
Croatian: Držite klip gurnut do kraja dok pažljivo podižete iglu s mjesta primjene injekcije.
English: In this study, most psoriatic arthritis patients receiving etanercept were able to mount effective B-cell immune response to pneumococcal polysaccharide vaccine, but titres in aggregate were moderately lower, and few patients had two-fold rises in titres compared to patients not receiving etanercept.
Croatian: ovom ispitivanju je većina bolesnika s psorijatičnim artritisom koji su primali etanercept mogla postići učinkovit imunološki odgovor B-stanica na pneumokokno polisaharidno cjepivo, iako su vrijednosti titra u agregatu bile umjereno niže, dok je nekoliko bolesnika imalo dvostruki porast titra u usporedbi s bolesnicima koji nisu primali etanercept.
English: Live vaccines should not be given concurrently with Erelzi.
Croatian: Živa cjepiva ne smiju se davati istodobno s Erelzijem.
English: ACR 20 and 50 responses were higher in patients treated with etanercept at 3 and 6 months than in patients treated with placebo (ACR 20: etanercept 62% and 59%, placebo 23% and 11% at 3 and 6 months, respectively: ACR 50: etanercept 41% and 40%, placebo 8% and 5% at months 3 and 6, respectively; p < 0.01 etanercept vs. placebo at all timepoints for both ACR 20 and ACR 50 responses).
Croatian: Učestalost odgovora ACR 20 i 50 bila je veća u bolesnika liječenih etanerceptom tijekom 3 i 6 mjeseci nego u bolesnika liječenih placebom (ACR 20: etanercept 62% i 59%, placebo 23% i 11% nakon 3 odnosno 6 mjeseci; ACR 50: etanercept 41% i 40%, placebo 8% i 5% nakon 3, odnosno 6 mjeseci;
English: The highest dose level evaluated has been an intravenous loading dose of 32 mg/m2 followed by subcutaneous doses of 16 mg/m2 administered twice weekly.
Croatian: Najviša ispitana udarna doza iznosila je 32 mg/m2 primijenjena intravenski nakon čega su slijedile supkutane doze od 16 mg/m2, primjenjivane dva puta tjedno.
English: Erelzi should be discarded if not used within four weeks after removal from the refrigerator.
Croatian: Erelzi treba baciti ako se ne upotrijebi u roku od četiri tjedna nakon što je izvađen iz hladnjaka.
English: Pharmacotherapeutic group: Immunosuppressants, tumour necrosis factor alpha (TNF-α) inhibitors, ATC code: L04AB01
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: imunosupresivi, inhibitori čimbenika nekroze tumora alfa (TNF-α), ATK
English: The central volume of distribution of etanercept is 7.6 l, while the volume of distribution at steady-state is 10.4 l. Elimination
Croatian: Središnji volumen raspodjele etanercepta iznosi 7,6 l, dok je volumen raspodjele u stanju dinamičke ravnoteže
English: Do not shake the syringe.
Croatian: Ne tresite štrcaljku.
English: Erelzi may be stored outside of the refrigerator at temperatures up to a maximum of 25 °C for a single period of up to four weeks; after which, it should not be refrigerated again.
Croatian: Erelzi se može čuvati izvan hladnjaka na temperaturi do najviše 25°C jednokratno do najdulje četiri tjedna poslije čega ga se ne smije staviti ponovo u hladnjak.
English: Based on the review of the literature and spontaneous reporting presented in this PSUSA, covering the period from 15 July 2018 to 14 January 2019, as well as cumulative data since the European birth date, the PRAC considered that a causal relationship between inflammatory bowel disease and etanercept cannot be excluded and therefore recommends that the product information of medicinal products containing the active substance etanercept should be updated as follows: update of section 4.8 of the SmPC to add inflammatory bowel disease with a frequency uncommon.
Croatian: PSUR-ova koja obuhvaća razdoblje od 15. srpnja 2018. do 14. siječnja 2019., kao i kumulativnih podataka od datuma prvog odobrenja koje je nositelju dano u nekoj zemlji članici EU, PRAC smatra da se uzročni odnos između upalne bolesti crijeva i etanercepta ne može isključiti te stoga preporučuje da se informacije o lijeku za lijekove koji sadrže djelatnu tvar etanercept ažuriraju kako slijedi: potrebno je ažurirati dio 4.8 sažetka opisa svojstava lijeka kako bi se uvrstila upalna bolest crijeva s učestalosti „manje često“.
English: • Using a circular motion, clean the injection site with the alcohol swab.
Croatian: • Kružnim pokretima očistite mjesto primjene alkoholnim tupferom.
English: In another observational multi-country registry study comparing the risk of adverse pregnancy outcomes in women exposed to etanercept during the first 90 days of pregnancy (n = 425) to those exposed to nonbiologic drugs (n = 3497), there was no observed increased risk of major birth defects (crude odds ratio [OR] = 1.22, 95% CI: 0.79 - 1.90; adjusted OR = 0.96, 95% CI: 0.58 - 1.60 after adjusting for country, maternal disease, parity, maternal age and smoking in early pregnancy).
Croatian: U drugom opservacijskom ispitivanju u obliku registra, provedenom u više država, koje je uspoređivalo rizik od štetnih ishoda trudnoća u žena izloženih etanerceptu tijekom prvih 90 dana trudnoće (n=425) i žena izloženih nebiološkim lijekovima (n=3 497), nije zabilježen povećan rizik od velikih urođenih mana (grubi omjer izgleda = 1,22; 95% CI: 0,79-1,90; prilagođen omjer izgleda = 0,96; 95% CI: 0,58-1,60 nakon prilagodbe prema državi, bolesti majke, paritetu, dobi majke i pušenju u ranom stadiju trudnoće).
English: Erelzi should be used with caution in patients with a history of hepatitis C.
Croatian: Erelzi se mora koristiti s oprezom u bolesnika s hepatitisom C u anamnezi.
English: Erelzi SensoReady pen shown with the cap removed.
Croatian: Erelzi SensoReady brizgalica prikazana s uklonjenim poklopcem.
English: Adjusted mean change from baseline was 3.8 for etanercept treated (n = 95) versus 0.8 for placebo treated (n = 105) patients (p < 0.001).
Croatian: Prilagođena srednja promjena u odnosu na početak iznosila je 3,8 u bolesnika liječenih etanerceptom (n = 95) naspram 0,8 u bolesnika liječenih placebom (n = 105) (p < 0,001).
English: If re-treatment with etanercept is indicated, the above guidance on treatment duration should be followed.
Croatian: Ako je indicirano ponovno liječenje etanerceptom, moraju se slijediti gore navedene smjernice o trajanju terapije.
English: The known side effects of Erelzi include the following in groups of decreasing frequency:
Croatian: Poznate nuspojave Erelzija uključuju sljedeće i prikazane su slijedom prema sve manjoj učestalosti:
English: Histiocytosis haematophagic (macrophage activation syndrome)*
Croatian: Hematofagičn a histiocitoza (sindrom aktivacije makrofaga)*
English: One hundred and twelve (112) patients were randomised to receive a dose of 25 mg of etanercept (n = 57) or placebo (n = 55) twice a week for 24 weeks.
Croatian: Sto dvanaest (112) bolesnika bilo je randomizirano tako da su primili dozu od 25 mg etanercepta (n = 57) ili placebo (n = 55) dvaput tjedno tijekom 24 tjedna.
English: • Signs of heart failure or worsening heart failure, such as fatigue or shortness of breath with activity, swelling in the ankles, a feeling of fullness in the neck or abdomen, night-time shortness of breath or coughing, bluish colour of the nails or the lips;
Croatian: • Znakovi zatajivanja srca ili pogoršanja zatajenja srca, kao što su umor ili nedostatak zraka prilikom aktivnosti, oticanje gležnjeva, osjećaj punoće u vratu ili trbuhu, nedostatak zraka ili kašalj tijekom noći, modra boja noktiju ili usana.
English: In a group of 2,711 plaque psoriasis patients treated with etanercept in double-blind and open-label studies of up to 2.5 years, 30 malignancies and 43 non-melanoma skin cancers were reported.
Croatian: U skupini od 2711 bolesnika s plak psorijazom liječenih etanerceptom u dvostruko slijepom, otvorenom ispitivanju u trajanju do 2,5 godine zabilježeno je 30 zloćudnih bolesti i 43 nemelanomska raka kože.
English: All patients should be informed to seek medical advice if signs/symptoms suggestive of tuberculosis (e.g., persistent cough, wasting/weight loss, low-grade fever) appear during or after Erelzi treatment.
Croatian: Svim bolesnicima treba savjetovati da potraže liječnički savjet u slučaju pojave znakova/simptoma koji upućuju na tuberkulozu (npr. stalni kašalj, mršavljenje/gubitak tjelesne težine, subfebrilnost) za vrijeme ili nakon liječenja Erelzijem.
English: Patients weighing less than 62.5 kg should be accurately dosed on a mg/kg basis using the powder and solvent for solution for injection presentations or the powder for solution for injection presentations (see below for dosing for specific indications).
Croatian: Bolesnici tjelesne težine manje od 62,5 kg trebaju primati točnu dozu u miligramima izračunatu prema broju kilograma (mg/kg), tako što će koristiti formulaciju praška i otapala za otopinu za injekciju ili formulaciju praška za otopinu za injekciju (vidjeti u nastavku doziranje za specifične indikacije).
English: In addition, one study found more birth defects when the mother had received etanercept in pregnancy, compared with mothers who had not received etanercept or other similar medicines (TNF-antagonists), but there was no particular kind of birth defect reported.
Croatian: Nadalje, jedno ispitivanje je zabilježilo više urođenih mana u slučaju kada je majka tijekom trudnoće primila etanercept u usporedbi s majkama koje nisu primile etanercept ili druge slične lijekove (antagoniste TNF-a), iako nije zabilježeno o kojem se tipu prijavljenih urođenih mana radi.
English: • Polyarthritis (rheumatoid factor positive or negative) and extended oligoarthritis in patients from the age of 2 years and weighing 62.5 kg or more.
Croatian: • Poliartikularni artritis (s pozitivnim ili negativnim reumatoidnim faktorom) i produljeni oligoartritis u bolesnika od navršene 2 godine života i tjelesne težine 62,5 kg ili više.
English: ASAS 20 2 weeks
Croatian: ASAS 20 2 tjedna
English: In a phase II randomised placebo-controlled study of 48 hospitalised patients treated with etanercept or placebo for moderate to severe alcoholic hepatitis, etanercept was not efficacious, and the mortality rate in patients treated with etanercept was significantly higher after 6 months.
Croatian: Alkoholni hepatitis U randomiziranom, placebom kontroliranom ispitivanju faze II u 48 hospitaliziranih bolesnika liječenih etanerceptom ili placebom zbog umjerenog do teškog alkoholnog hepatitisa etanercept nije bio djelotvoran, a stopa smrtnosti u bolesnika liječenih etanerceptom nakon 6 mjeseci bila je značajno viša.
English: 70b a: 25 mg etanercept SC twice weekly b: p < 0.001, etanercept vs. placebo c: p < 0.01, etanercept vs. placebo
Croatian: 70b a: 25 mg etanercepta supkutano, dva puta tjedno b: p < 0,001, etanercept u odnosu na placebo c: p < 0,01, etanercept u odnosu na placebo
English: Reactivation of hepatitis B in patients who were previously infected with the hepatitis B virus (HBV) and had received concomitant TNF-antagonists, including etanercept, has been reported.
Croatian: Reaktivacija hepatitisa B Zabilježena je reaktivacija hepatitisa B u bolesnika koji su prethodno bili zaraženi virusom hepatitisa B (HBV) i primali antagoniste TNF-a, uključujući etanercept.
English: In addition, in a double-blind, placebo-controlled trial in adult patients receiving background methotrexate, patients treated with etanercept and anakinra were observed to have a higher rate of serious infections (7%) and neutropenia than patients treated with etanercept (see sections 4.4 and 4.8).
Croatian: Osim toga, u dvostruko slijepom, placebom kontroliranom ispitivanju u odraslih bolesnika koji su primali osnovnu terapiju metotreksatom, opaženo je da bolesnici koji su liječeni etanerceptom i anakinrom imaju povećanu stopu ozbiljnih infekcija (7%) i neutropenije u odnosu na bolesnike liječene samo etanerceptom (vidjeti dijelove 4.4 i 4.8).
English: A placebo-controlled trial, in which 89 adult patients were treated with etanercept in addition to standard therapy (including cyclophosphamide or methotrexate, and glucocorticoids) for a median duration of 25 months, has not shown etanercept to be an effective treatment for Wegener's granulomatosis.
Croatian: Wegenerova granulomatoza Placebom kontrolirano ispitivanje u kojem je 89 odraslih bolesnika liječeno etanerceptom koji je dodan standardnoj terapiji (koja je uključivala ciklofosfamid ili metotreksat te glukokortikoide) s medijanom trajanja od 25 mjeseci nije pokazalo da je etanercept učinkovit u liječenju Wegenerove granulomatoze.
English: For psoriatic arthritis patients with multiple joint involvement, Erelzi can improve your ability to do normal daily activities.
Croatian: U bolesnika s psorijatičnim artritisom koji zahvaća više zglobova Erelzi može poboljšati sposobnost obavljanja uobičajenih dnevnih aktivnosti.
English: • Cancer: Tell your doctor if you have or have ever had lymphoma (a type of blood cancer) or any other cancer before you are given Erelzi.
Croatian: • Rak: prije nego započnete liječenje Erelzijem obavijestite svog liječnika ako imate ili ste ikad imali limfom (vrsta raka krvi) ili bilo koji drugi rak.
English: Caution: Keep the syringe out of the sight and reach of children.
Croatian: Oprez: Čuvajte štrcaljke izvan pogleda i dohvata djece.
English: After a single subcutaneous dose of 25 mg etanercept, the average maximum serum concentration observed in healthy volunteers was 1.65 ± 0.66 µg/ml, and the area under the curve was 235 ± 96.6 µg•hr/ml.
Croatian: Prosječna maksimalna serumska koncentracija zabilježena u zdravih dobrovoljaca nakon jednokratne supkutane doze etanercepta od 25 mg iznosila je 1,65 ± 0,66 μg/ml, a površina ispod krivulje iznosila je 235 ± 96,6 µg
English: Your doctor will decide how long you should use Erelzi and whether retreatment is needed based on your response.
Croatian: Na temelju Vašeg odgovora na liječenje liječnik će odlučiti koliko dugo trebate primjenjivati Erelzi i je li potrebno ponoviti liječenje.
English: Thrombocytopenia, anaemia, leukopenia, neutropenia
Croatian: Trombocitopenij a, anemija, leukopenija, neutropenija
English: TNF and lymphotoxin are pro-inflammatory cytokines that bind to two distinct cell surface receptors: the 55-kilodalton (p55)
Croatian: TNF i limfotoksin su pro-upalni citokini koji se vežu na dva različita receptora na površini stanice: receptore čimbenika nekroze tumora (TNFR) veličine 55 kilodaltona (p55) i
English: Contents of the pack and other information Instructions for Use of the Erelzi pre-filled syringe (see overleaf)
Croatian: Sadržaj pakiranja i druge informacije Upute za primjenu napunjene štrcaljke Erelzi (vidjeti na poleđini)
English: Instructions for use and handling of the Erelzi pre-filled syringe Before injection, Erelzi single-use pre-filled syringe should be allowed to reach room temperature (approximately 15 to 30 minutes).
Croatian: Upute za uporabu i rukovanje napunjenom štrcaljkom Erelzi Prije injekcije, Erelzi napunjena štrcaljka za jednokratnu uporabu treba se ostaviti na sobnoj temperaturi (približno 15 do 30 minuta).
English: Each pack contains 1, 2 or 4 pens, multipacks contain 12 (3 packs of 4) pens.
Croatian: Jedno pakiranje sadrži 1, 2 ili 4 brizgalice, višestruka pakiranja sadrže 12 (3 pakiranja po 4) brizgalica.
English: Do not use if the safety seal has been broken.
Croatian: Ne upotrebljavajte ako je zaštitna naljepnica potrgana.
English: Store in the refrigerator between 2 °C to 8 °C.
Croatian: Čuvajte u hladnjaku na temperaturi između 2 °C do 8 °C.
English: n = 166 n =
Croatian: n = 166 tj.
English: In part 2, patients with a clinical response at day 90 were randomised to remain on etanercept or receive placebo for four months and assessed for disease flare.
Croatian: U drugom dijelu, bolesnici s kliničkim odgovorom 90. dana randomizirani su da i dalje primaju etanercept ili placebo kroz četiri mjeseca i zatim je procijenjeno pogoršanje bolesti.
English: After 12 weeks of treatment, patients in the placebo group began treatment with blinded etanercept (25 mg twice a week); patients in the active treatment groups continued to week 24 on the dose to which they were originally randomised.
Croatian: Nakon 12 tjedana liječenja bolesnici u placebo skupini su počinjali slijepo liječenje etanerceptom (25 mg dvaput tjedno), a bolesnici u aktivnoj skupini nastavljali su liječenje do kraja 24. tjedna dozom na koju su od početka randomizirani.
English: Melanoma and non-melanoma skin cancer (NMSC) have been reported in patients treated with TNF-antagonists, including etanercept.
Croatian: Rak kože Melanom i nemelanomski rak kože (engl. non-melanoma skin cancer, NMSC) primijećeni su u bolesnika liječenih antagonistima TNF-a, uključujući etanercept.
English: red, or scaly skin patches or lesions (“psoriasis skin lesions”).
Croatian: zadebljala, crvena ili ljuskama prekrivena područja kože ili lezije („psorijatične kožne lezije“)
English: Erelzi is administered by an injection under the skin (by subcutaneous injection).
Croatian: Erelzi se daje injekcijom pod kožu (supkutanom injekcijom).
English: Erelzi may be stored at temperatures up to a maximum of 25 °C for a single period of up to four weeks; after which, it should not be refrigerated again.
Croatian: Erelzi se može čuvati na temperaturi do maksimalno 25°C jednokratno do najduže četiri tjedna poslije čega se ne smije vratiti u hladnjak.
English: Study 1 was a Phase 2 study in patients with active, but clinically stable, plaque psoriasis involving ≥ 10% of the body surface area who were ≥ 18 years old.
Croatian: Ispitivanje 1 je bilo ispitivanje faze II u koje su uključeni bolesnici s aktivnom, ali klinički stabilnom plak psorijazom koja zahvaća ≥ 10% površine tijela u dobi
English: In plaque psoriasis, infiltration by inflammatory cells, including T-cells, leads to increased TNF levels in psoriatic lesions compared with levels in uninvolved skin.
Croatian: Kod plak psorijaze infiltracija upalnim stanicama uključujući T stanice vodi do porasta razine TNF-a u psorijatičnim lezijama u usporedbi s razinama istih u koži koja nije promijenjena.
English: Vasculitis (including antineutrophilic cytoplasmic antibody positive vasculitis)
Croatian: (uključujući vaskulitis s pozitivnim antineutrofilnim citoplazmatskim protutijelima)
English: Choose your injection site:
Croatian: Odaberite mjesto primjene injekcije:
English: Caution should be exercised when considering TNF-antagonist therapy for patients with a history of malignancy or when considering continuing treatment in patients who develop a malignancy.
Croatian: Treba biti oprezan kada se razmatra liječenje antagonistima TNF-a bolesnika koji u anamnezi imaju zloćudne bolesti, kao i kada se razmatra nastavak liječenja bolesnika koji su razvili zloćudnu bolest.
English: 28b a: p < 0.001, etanercept vs. placebo b: p = 0.002, etanercept vs. placebo
Croatian: 28b a: p<0,001, etanercept u odnosu na placebo b: p = 0,002, etanercept u odnosu na placebo
English: Some vaccines, such as oral polio vaccine, should not be given while using Erelzi.
Croatian: Neka cjepiva, kao oralno cjepivo protiv poliomijelitisa, ne bi se trebala davati za vrijeme liječenja Erelzijem.
English: Patients currently on methotrexate therapy (stable for ≥ 2 months) could continue at a stable dose of ≤ 25 mg/week methotrexate.
Croatian: Bolesnici koji su u tom trenutku primali metotreksat (stabilni ≥ 2 mjeseca) mogli su nastaviti s njegovom primjenom u stalnoj dozi od ≤ 25 mg tjedno.
English: • Signs of serious infections such as high fever that may be accompanied by cough, shortness of breath, chills, weakness, or a hot, red, tender, sore area on the skin or joints;
Croatian: • Znakovi ozbiljne infekcije, kao što su visoka temperatura koja može biti praćena kašljem, nedostatkom zraka, zimicom, slabošću ili toplim, crvenim, osjetljivim, bolnim područjem na koži ili zglobovima.
English: All healthcare professionals (HCPs) who are most likely to prescribe Erelzi for patients with rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis including ankylosing spondylitis, juvenile idiopathic arthritis, plaque psoriasis and paediatric plaque psoriasis are provided with a Patient Alert Card for distribution to patients receiving Erelzi.
Croatian: Svim zdravstvenim radnicima koji će najvjerojatnije propisivati lijek Erelzi bolesnicima s reumatoidnim artritisom, psorijatičkim artritisom, aksijalnim spondiloartritisom, uključujući ankilozantni spondilitis, juvenalni idiopatski artritis, plak psorijazu i pedijatrijsku plak psorijazu izdaje se Kartica s upozorenjima za bolesnika koju će dijeliti bolesnicima koji primaju Erelzi.
English: Of the rheumatoid arthritis patients evaluated for antinuclear antibodies (ANA), the percentage of patients who developed new positive ANA (≥ 1:40) was higher in patients treated with etanercept (11%) than in placebo-treated patients (5%).
Croatian: Među bolesnicima s reumatoidnim artritisom u kojih su određivana antinuklearna protutijela (ANA) veći je postotak novopozitivnih na ANA (≥ 1:40) bio među onima liječenima etanerceptom (11%) nego među onima koji su primali placebo (5%).
English: There is insufficient evidence of the efficacy of etanercept in patients with ankylosing spondylitis-like and arthritis mutilans psoriatic arthropathies due to the small number of patients studied.
Croatian: Nema dovoljno dokaza o djelotvornosti etanercepta u bolesnika s psorijatičnim artropatijama koje su slične ankilozantnom spondilitisu i artritis mutilansu, zbog malog broja ispitivanih bolesnika.
English: In this configuration the needle guard is ACTIVATEDDO NOT USE the pre-filled syringe
Croatian: U ovom položaju štitnik igle je AKTIVIRAN - NE KORISTITE napunjenu štrcaljku
English: Erelzi in combination with methotrexate is indicated for the treatment of moderate to severe active rheumatoid arthritis in adults when the response to disease-modifying antirheumatic drugs, including methotrexate (unless contraindicated), has been inadequate.
Croatian: Erelzi je u kombinaciji s metotreksatom indiciran za liječenje umjerenog do teškog aktivnog reumatoidnog artritisa u odraslih u slučaju neadekvatnog odgovora na antireumatske lijekove koji modificiraju tijek bolesti, uključivši metotreksat (osim ako je kontraindiciran).
English: Physicians should use caution when using Erelzi in patients who also have moderate to severe alcoholic hepatitis.
Croatian: Liječnici moraju biti oprezni kada primjenjuju Erelzi u bolesnika koji boluju od umjerenog do teškog alkoholnog hepatitisa.