FrancophonIA/ELRC3.0 huggingface dataset:
English: Cytotoxic agents may decrease the intestinal absorption of phenytoin.
Danish: Cytotoksiske midler kan reducere tarmenes absorption af fenytoin.
English: Avoid contact of Xaluprine with your skin, eyes or nose.
Danish: Undgå, at Xaluprine kommer i kontakt med hud, øjne eller næse.
English: Xanthine oxidase is the main catabolic enzyme and it converts the 6-mercaptopurine into the inactive metabolite, 6-thiouric acid.
Danish: Xanthinoxidase er det væsentligste katabolenzym og konverterer 6-mercaptopurin til den inaktive metabolit, 6-thiourinsyre.
English: Xaluprine contains aspartame (E951) which contains a source of phenylalanine.
Danish: Xaluprine indeholder aspartam (E951), som indeholder en kilde til fenylalanin.
English: You should use this one if the total amount you have to take is more than 1 ml (each graduation of 0.2 ml contains 4 mg of mercaptopurine).
Danish: Du skal bruge denne sprøjte, hvis den samlede mængde, du skal tage, er mere end 1 ml (hver graduering af 0,2 ml indeholder 4 mg mercaptopurin).
English: INFORMATION IN BRAILLE Xaluprine 20 mg/ml
Danish: INFORMATION I BRAILLESKRIFT Xaluprine 20 mg/ml
English: *inflammatory bowel disease (IBD) is an unlicensed indication
Danish: *inflammatorisk tarmsygdom er en uautoriseret indikation.
English: The larger 5 ml syringe (white), marked 1 ml to 5 ml, is for measuring doses of more than 1 ml.
Danish: Den større 5 ml sprøjte (hvid), markeret fra 1 ml til 5 ml, er til opmåling af doser, som er større end 1 ml.
English: Rare (affects less than 1 in 1,000 people) - hair loss - in men: temporary low sperm count - swollen face - various types of cancers including blood, lymph and skin cancers
Danish: Sjældne (rammer mindre end 1 ud af 1.000) - hårtab - hos mænd: midlertidigt lavt sædcelletal - hævelser i ansigtet - forskellige former for kræft, herunder blodkræft, lymfekræft og hudkræft
English: Serum antiepileptic levels should be closely monitored during treatment with Xaluprine, making dose adjustments as necessary.
Danish: Serumniveauet af antiepileptika skal overvåges nøje under behandling med Xaluprine, og dosen skal justeres efter behov.
English: These patients generally require dose reduction; particularly those being NUDT15 variant homozygotes (see 4.4).
Danish: Disse patienter kræver generelt en dosisreduktion; særligt de patienter, der er homozygote for NUDT15-varianten (se pkt.
English: Patients with inherited mutated NUDT15 gene are at increased risk for severe 6-mercaptopurine toxicity, such as early leukopenia and alopecia, from conventional doses of thiopurine therapy.
Danish: Patienter med et nedarvet, muteret NUDT15-gen har en øget risiko for alvorlig 6mercaptopurintoksicitet, såsom tidlig leukopeni og alopeci, fra konventionelle doser thiopurinbehandling.
English: Transient profound oligospermia has been reported following exposure to 6-mercaptopurine in combination with corticosteroids.
Danish: Forbigående udbredt oligospermi er rapporteret efter eksponering for 6-mercaptopurin i kombination med kortikosteroider.
English: (≥1/1000 to < 1/100), rare (≥1/10,000 to < 1/1000) and very rare (< 1/10,000).
Danish: Bivirkningerne er angivet ud fra systemorganklasse og hyppighed: meget almindelig (≥ 1/10), almindelig (≥ 1/100 til < 1/10), ikke almindelig (≥ 1/1.000 til < 1/100), sjælden (≥ 1/10.000 til < 1/1.000) og meget sjælden (< 1/10.000).
English: If you take more Xaluprine than you should, tell your doctor or go to a hospital immediately.
Danish: Hvis du tager for meget Xaluprine, skal du straks søge læge eller tage på hospitalet.
English: - other cytotoxic medicines (chemotherapy) - when used with Xaluprine there is a greater chance of side effects, such as anaemia - allopurinol or febuxostat (used to treat gout) - oral anticoagulants (used to thin the blood) - olsalazine or mesalazine (used for a bowel disorder called ulcerative colitis) - sulfasalazine (used for rheumatoid arthritis or ulcerative colitis).
Danish: - andre cytotoksiske lægemidler (kemoterapi) - når de anvendes sammen med Xaluprine, er der større risiko for bivirkninger som for eksempel anæmi - allopurinol eller febuxostat (anvendes til behandling af urinsyregigt) - orale antikoagulerende midler (anvendes til at fortynde blodet) - olsalazin eller mesalazin (anvendes til en tarmlidelse ved navn ulcerativ colitis)
English: Xaluprine may be taken with food or on an empty stomach, but patients should standardise the method of administration.
Danish: Xaluprine kan tages sammen med mad eller på tom mave, men patienter bør standardisere deres administrationsmetode.
English: A possible association between decreased TPMT activity and secondary leukaemias and myelodysplasia has been reported in individuals receiving 6-mercaptopurine in combination with other cytotoxics (see section 4.8).
Danish: En mulig forbindelse mellem reduceret TPMT-aktivitet og sekundær leukæmi og myelodysplasi er rapporteret hos personer, som fik 6-mercaptopurin i kombination med andre cytotoksiske midler (se pkt.
English: A combination of multiple immunosuppressants, given concomitantly increases the risk of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders.
Danish: En kombination af flere immunsuppressiva administreret samtidigt øger risikoen for Epstein-Barr-virus (EBV) -relaterede lymfoproliferative sygdomme.
English: Always take Xaluprine exactly as your doctor or pharmacist has told you.
Danish: Tag altid Xaluprine nøjagtigt efter lægens eller apotekspersonalets anvisning.
English: Some patients with inflammatory bowel disease who have received 6-mercaptopurine have developed a rare and aggressive type of cancer called Hepatosplenic T-cell Lymphoma (see section 4, Possible side effects).
Danish: Nogle patienter med inflammatorisk tarmsygdom, som har fået 6-mercaptopurin, har udviklet en sjælden og aggressiv form for kræft, der kaldes hepatosplenisk T-celle lymfom (se punk.
English: Combination with xanthine oxidase inhibitors
Danish: Kombination med xanthinoxidasehæmmere
English: Neoplasms including lymphoproliferative disorders, skin cancers (melanomas and non-melanomas), sarcomas (Kaposi's and non-Kaposi's) and uterine cervical cancer in situ (see section 4.4).
Danish: Neoplasmer, herunder lymfoproliferative sygdomme, hudcancer (melanom og non-melanom), sarkomer (Kaposi og non-Kaposi) og cervixcancer in situ (se pkt.
English: The risk of overdose is also increased when xanthine oxidase inhibitors is being given concomitantly with 6-mercaptopurine (see section 4.5).
Danish: Risikoen for overdosering er ligeledes øget, når xanthinoxidasehæmmere gives samtidig med 6-mercaptopurin (se pkt.
English: The smaller 1 ml syringe (purple), marked from 0.1 ml to 1 ml, is for measuring doses of less than or equal to 1 ml.
Danish: Den mindste 1 ml sprøjte (violet), markeret fra 0,1 til 1,0 ml, er til opmåling af doser, som er mindre end eller lig med 1 ml.
English: Very rare (affects less than 1 in 10,000 people) - a different type of leukaemia to that being treated - ulcers in the intestines
Danish: Meget sjældne (rammer mindre end 1 ud af 10.000) - en anden type leukæmi end den, der behandles - sår på tarmene
English: Pancreatitis in off-label treatment of patients with inflammatory bowel disease Pancreatitis has been reported to occur at a frequency of ≥ 1/100 to < 1/10 (“common”) in patients treated for the unlicensed indication inflammatory bowel disease.
Danish: Der er indberettet tilfælde af pankreatitis med en hyppighed på ≥ 1/100 til < 1/10 (“almindelig”) hos patienter, der behandles for den ikke-godkendte indikation inflammatorisk tarmsygdom.
English: For mercaptopurine there is a lack of modern clinical documentation which can serve as support for accurately determining the frequency of adverse reactions.
Danish: Der foreligger ikke tilstrækkelig nyere klinisk dokumentation for mercaptopurin, som kan understøtte nøjagtig påvisning af hyppigheden af bivirkninger.
English: Other xanthine oxidase inhibitors should be avoided (see section 4.5).
Danish: Andre xanthinoxidasehæmmere skal undgås (se pkt.
English: Two dosing syringes (a purple syringe graduated to 1 ml and a white syringe graduated to 5 ml) are provided for accurate measurement of the prescribed dose of the oral suspension.
Danish: Der medfølger to dosissprøjter (en violet sprøjte gradueret til 1 ml og en hvid sprøjte gradueret til 5 ml) til nøjagtig opmåling af den ordinerede dosis oral suspension.
English: Accidental ingestion can be lethal for children.
Danish: Utilsigtet indtagelse kan være dødelig for børn.
English: Parents and care givers should avoid Xaluprine contact with skin or mucous membrane.
Danish: Forældre og plejepersoner bør undgå, at Xaluprine kommer i kontakt med hud eller slimhinder.
English: In any case, close monitoring of blood counts is necessary.
Danish: Det er i alle tilfælde nødvendigt at monitorere blodtallene nøje.
English: You should use this one if the total amount you have to take is less than or equal to 1 ml (each graduation of 0.1 ml contains 2 mg of mercaptopurine).
Danish: Du skal bruge denne sprøjte, hvis den samlede mængde, du skal tage, er mindre end eller lig med 1 ml (hver graduering af 0,1 ml indeholder 2 mg mercaptopurin).
English: 6-mercaptopurine, in common with other antimetabolites, is mutagenic and causes chromosomal aberrations in vitro and in vivo in mice and rats.
Danish: 6-mercaptopurin er som andre antimetabolitter mutagen og forårsager kromosomafvigelser in vitro og in vivo hos mus og rotter.
English: Therefore, Xaluprine may be taken with food or on an empty stomach, but patients should standardise the method of administration.
Danish: Derfor kan Xaluprine tages sammen med mad eller på tom mave, men patienter bør standardisere deres administrationsmetode.
English: They generally require dose reduction, particularly those being NUDT15 variant homozygotes (see 4.2).
Danish: De kræver generelt en dosisreduktion, særligt de patienter, der er homozygote for NUDT15-varianten (se pkt.
English: Put on disposable hand gloves before handling Xaluprine.
Danish: Tag engangshandsker på, inden du håndterer Xaluprine.
English: Allopurinol and other xanthine oxidase inhibitors decrease the rate of catabolism of 6-mercaptopurine.
Danish: Allopurinol og andre xanthinoxidasehæmmere reducerer 6-mercaptopurins katabolismehastighed.
English: When you use the medicine follow the instructions below:
Danish: Følg nedenstående instruktioner, når du tager medicinen:
English: The patient should be instructed to discontinue Xaluprine immediately if jaundice becomes apparent (see section 4.8).
Danish: Patienten skal instrueres i omgående at ophøre med at tage Xaluprine, hvis der er tegn på gulsot (se pkt.
English: PHARMACEUTICAL FORM AND CONTENTS Oral suspension.
Danish: LÆGEMIDDELFORM OG INDHOLD (PAKNINGSSTØRRELSE) Oral suspension.
English: Patients receiving immunosuppressive therapy, including mercaptopurine, are at an increased risk of developing lymphoproliferative disorders and other malignancies, notably skin cancers (melanoma and non-melanoma), sarcomas (Kaposi's and non-Kaposi's) and uterine cervical cancer in situ.
Danish: Patienter i immunsupprimerende behandling, herunder med mercaptopurin, har en øget risiko for at udvikle lymfoproliferative sygdomme og andre maligniteter, især hudcancer (melanom og non-melanom), sarkomer (Kaposi og non-Kaposi) og cervixcancer in situ.
English: If you stop taking Xaluprine
Danish: Hvis du holder op med at tage Xaluprine
English: The intracellular anabolism of 6-merpactopurine is catalysed by several enzymes to eventually form 6-thioguanine nucleotides (TGNs), but a variety of intermediary TGNs are formed en route to the TGNs.
Danish: 6-merpactopurins intracellulære anabolisme katalyseres af flere enzymer til dannelse af 6-thioguanin-nukleotider (TGN'er), men der dannes flere forskellige midlertidige TGN'er i processen mod TGN'er.
English: Cases of neutropenic sepsis have been reported in patients receiving 6-mercaptopurine for ALL.
Danish: Der er indberettet tilfælde af neutropenisk sepsis hos patienter med ALL, der fik 6-mercaptopurin.
English: TPMT also catalyses the S-methylation of the principle nucleotide metabolite, TIMP, to form methylthioinosine monophosphate (mTIMP).
Danish: TPMT katalyserer imidlertid også S-methyleringen af den primære nukleotide metabolit, TIMP, og danner methylthioinosin-monofosfat (mTIMP).
English: - Keep this medicine out of the sight and reach of children, preferably in a locked cupboard.
Danish: Opbevaring - Opbevar lægemidlet utilgængeligt for børn, helst i et låst skab.
English: Xaluprine contains mercaptopurine.
Danish: Xaluprine indeholder mercaptopurin.
English: Treatment with 6-mercaptopurine causes bone marrow suppression leading to leucopenia and thrombocytopenia and, less frequently, to anaemia.
Danish: Behandling med 6-mercaptopurin forårsager knoglemarvssuppression, som fører til leukopeni og trombocytopeni og mindre hyppigt til anæmi.
English: Patients should be closely monitored for dose related adverse reactions (see section 4.4).
Danish: Patienter skal monitoreres nøje for dosisrelaterede bivirkninger (se pkt.
English: Ensure that the cap is tightly closed.
Danish: Kontrollér, at hætten er lukket tæt.
English: Contraception in males and females
Danish: Kontraception til mænd og kvinder.
English: Effects of mercaptopurine on other medicinal products Concomitant administration of yellow fever vaccine is contraindicated, due to the risk of fatal disease in immunocompromised patients (see section 4.3)
Danish: Samtidig administration af vaccine mod gul feber er kontraindiceret på grund af risikoen for dødelig sygdom hos immunkompromitterede patienter (se pkt.
English: Multiple congenital abnormalities have been reported following maternal 6-mercatopurine treatment in combination with other chemotherapy agents.
Danish: Flere medfødte abnormiteter har været rapporteret efter behandling af moderen med 6-mercaptopurin i kombination med andre kemoterapimidler.
English: Macrophage activation syndrome
Danish: Makrofag-aktiveringssyndrom
English: Since 6-mercaptopurine pharmacokinetics has not been formally studied in renal impairment, no specific dose recommendations can be given.
Danish: Da farmakokinetikken for 6-mercaptopurin ikke er formelt undersøgt ved nyreinsufficiens, kan der ikke gives nogen specifikke dosisanbefalinger.
English: Other side effects (the frequency is unknown) - a rare type of cancer (hepatosplenic T-cell lymphoma), (see section 2, Warnings and
Danish: Andre bivirkninger (ikke kendt hyppighed) - en sjælden type kræft (hepatosplenisk T-celle lymfom (se punkt 2, Advarsler og forsigtighedsregler) - Overfølsomhed over for sollys, der giver hudreaktioner
English: One ml of suspension contains 3 mg aspartame, 1 mg methyl hydroxybenzoate (as the sodium salt), 0.5 mg ethyl hydroxybenzoate (as the sodium salt) and sucrose (trace).
Danish: 1 ml suspension indeholder 3 mg aspartam, 1 mg methylhydroxybenzoat (som natriumsalt), 0,5 mg ethylhydroxybenzoat (som natriumsalt) og sakkarose (spor).
English: It also contains sodium methyl parahydroxybenzoate and sodium ethyl parahydroxybenzoate which may cause allergic reaction (possibly delayed).
Danish: Lægemidlet indeholder også natriummethylparahydroxybenzoat og natriumethylparahydroxybenzoater, som kan give allergiske reaktioner (muligvis forsinkede).
English: Patients with inherited mutated NUDT15 gene are at increased risk for severe 6-mercaptopurine toxicity, (see 4.4).
Danish: Patienter med et nedarvet, muteret NUDT15-gen har en øget risiko for alvorlig 6mercaptopurintoksicitet (se pkt.
English: Since 6-mercaptopurine pharmacokinetics has not been formally studied in hepatic impairment, no specific dose recommendations can be given.
Danish: Da farmakokinetikken for 6-mercaptopurin ikke er formelt undersøgt ved leverinsufficiens, kan der ikke gives nogen specifikke dosisanbefalinger.
English: The main adverse reaction of treatment with 6-mercaptopurine is bone marrow suppression leading to leucopenia and thrombocytopenia.
Danish: De vigtigste bivirkninger ved behandling med 6-mercaptopurin er knoglemarvssuppression, som fører til leukopeni og trombocytopeni.
English: BATCH NUMBER Lot:
Danish: FREMSTILLERENS BATCHNUMMER Parti:
English: Your doctor or pharmacist will advise which syringe to use depending on the dose that has been prescribed.
Danish: Din læge eller apotekspersonalet vil fortælle dig, hvilken sprøjte du skal bruge, afhængigt af den ordinerede dosis.
English: Effects of other medicinal products on mercaptopurine When allopurinol and Xaluprine are administered concomitantly it is essential that only a quarter of the usual dose of Xaluprine is given since allopurinol decreases the rate of metabolism of 6-mercaptopurine via xanthine oxidase.
Danish: Når allopurinol og Xaluprine administreres samtidig, er det essentielt, at der kun gives en fjerdedel af den sædvanlige dosis Xaluprine, da allopurinol reducerer 6-mercaptopurins metaboliseringshastighed via xanthinoxidase.
English: What Xaluprine looks like and contents of the pack Xaluprine is a pink to brown oral suspension.
Danish: Xaluprine er en lyserød til brun oral suspension.
English: Do not breast-feed while taking Xaluprine.
Danish: Du må ikke amme, mens du tager Xaluprine.
English: What you need to know before you take Xaluprine
Danish: Det skal du vide, før du begynder at tage Xaluprine
English: Inhibition of the anticoagulant effect of warfarin, when given with 6-mercaptopurine, has been reported.
Danish: Der er rapporteret om hæmning af warfarins antikoagulerende virkning, når midlet gives samtidig med 6-mercaptopurin.
English: Biliary stasis, hepatotoxicity
Danish: Galdestase, hepatotoksicitet
English: QUALITATIVE AND QUANTITATIVE COMPOSITION One ml of suspension contains 20 mg mercaptopurine (as monohydrate).
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING 1 ml suspension indeholder 20 mg mercaptopurin (som monohydrat).
English: One ml of suspension contains 20 mg of mercaptopurine monohydrate.
Danish: 1 ml suspension indeholder 20 mg mercaptopurin-monohydrat.
English: Your doctor or pharmacist will advise which syringe to use depending on the dose that has been prescribed
Danish: Din læge eller apotekspersonalet fortæller dig, hvilken sprøjte du skal bruge afhængig af den ordinerede dosis.
English: Xaluprine contains sucrose.
Danish: Xaluprine indeholder saccharose.
English: Bone marrow suppression; leucopenia and thrombocytopenia
Danish: Knoglemarvssuppression, leukopeni og trombocytopeni
English: What Xaluprine contains
Danish: Xaluprine indeholder:
English: Xaluprine also contains sodium methyl parahydroxybenzoate (E219) and sodium ethyl parahydroxybenzoate (E215) which may cause allergic reactions (possibly delayed).
Danish: Xaluprine indeholder også natriummethylparahydroxybenzoat (E219) og natriumethylparahydroxy-benzoat (E215), som kan give allergiske reaktioner (muligvis forsinkede).
English: The 6-mercaptopurine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions.
Danish: 6-mercaptopurin-metabolitter hæmmer den indbyrdes konvertering af de novo-purinsyntese og purinnukleotider.
English: Uncommon (affects less than 1 in 100 people) - mouth ulcers - inflamed pancreas - joint pain - skin rash - fever - permanent damage to the liver (hepatic necrosis)
Danish: Ikke almindelige (rammer mindre end 1 ud af 100) - mundsår - betændelse i bugspytkirtlen - ledsmerter - hududslæt - feber - permanent leverskade (levernekrose)
English: Xaluprine may be taken with food or on an empty stomach.
Danish: Brug af Xaluprine sammen med mad og drikke Xaluprine kan tages sammen med mad eller på tom mave.
English: Cases of symptomatic hypoglycaemia have been reported in children with ALL receiving 6-mercaptopurine (see section 4.8).
Danish: Der er indberettet tilfælde af symptomatisk hypoglykæmi hos børn med ALL, som fik 6-mercaptopurin (se pkt.
English: Taking Xaluprine could put you at greater risk of: - developing a serious condition called Macrophage Activation Syndrome (excessive activation of white blood cells associated with inflammation), which usually occurs in people who have certain types of arthritis
Danish: Behandling med Xaluprine kan medføre øget risiko for: - udvikling af en alvorlig lidelse, der hedder makrofag-aktiveringssyndrom (kraftig aktivering af hvide blodlegemer forbundet med en betændelseslignende reaktion (inflammation)).
English: If the suspension comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water (see section 6.6).
Danish: Skyl øjeblikkeligt og grundigt med sæbe og vand (se pkt.
English: Your pack of Xaluprine contains a bottle of medicine, a cap, a bottle adaptor and two dosing syringes (a purple 1 ml syringe and a white 5 ml syringe).
Danish: Hver pakning af Xaluprine indeholder en flaske med medicin, en hætte, en flaskeadapter og to doseringssprøjter (en violet 1 ml sprøjte og en hvid 5 ml sprøjte).
English: MARKETING AUTHORISATION HOLDER Nova Laboratories Ireland Limited 3rd Floor, Ulysses House Foley Street, Dublin 1
Danish: INDEHAVER AF MARKEDSFØRINGSTILLADELSEN Nova Laboratories Ireland Limited 3rd Floor, Ulysses House
English: Turn the bottle back the right way up and carefully remove the syringe from the adaptor, holding it by the barrel rather than the plunger.
Danish: Vend flasken, så den vender rigtigt, og træk forsigtigt sprøjten ud af adapteren.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 09 March 2012
Danish: DATO FOR FØRSTE MARKEDSFØRINGSTILLADELSE/FORNYELSE AF TILLADELSEN
English: Depending on phase of treatment, starting or target doses generally vary between 25-75 mg/m2 body surface area (BSA) per day, but should be lower in patients with reduced or absent Thiopurine Methyl Transferase (TPMT) enzyme activity (see section 4.4).
Danish: legemsoverfladeareal (BSA) dagligt, men bør være lavere hos patienter med reduceret eller ingen thiopurinmethyltransferase (TPMT)-enzymaktivitet (se pkt.
English: The expiry date refers to the last day of that month, - Do not store above 25°C.
Danish: Udløbsdatoen er den sidste dag i den nævnte måned.
English: Therefore, when taking Xaluprine, avoid excessive exposure to sunlight, wear protective clothing and use protective sunscreen with a high protection factor - lymphoproliferative disorders o treatment with Xaluprine increases your risk of getting a type of cancer called lymphoproliferative disorder.
Danish: Når du tager Xaluprine, skal du derfor undgå for megen eksponering for sollys, og du skal bruge beskyttende påklædning og solcreme med høj beskyttelsesfaktor.
English: Each pack contains one bottle, a bottle adaptor and two dosing syringes (a purple syringe graduated to 1 ml and a white syringe graduated to 5 ml).
Danish: Hver pakning indeholder en flaske, en flaskeadapter og to doseringssprøjter (en violet sprøjte gradueret til 1 ml og en hvid sprøjte gradueret til 5 ml).
English: Each pack contains one bottle, an HDPE bottle adaptor and 2 polyethylene dosing syringes (a purple syringe graduated to 1 ml and a white syringe graduated to 5 ml).
Danish: Hver pakning indeholder en flaske, en HDPE-flaskeadapter og 2 polyethylen-doseringssprøjter (en violet sprøjte gradueret til 1 ml og en hvid sprøjte gradueret til 5 ml).
English: STATEMENT OF ACTIVE SUBSTANCE(S) One ml of suspension contains 20 mg mercaptopurine (as monohydrate).
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER 1 ml suspension indeholder 20 mg mercaptopurin (som monohydrat).
English: Arthralgia, skin rash, drug fever
Danish: Arthralgi, udslæt, lægemiddelinduceret feber
English: olsalazine, mesalazine or sulfazalazine) inhibit the TPMT enzyme, which metabolises 6-mercaptopurine, they should be administered with caution to patients receiving concurrent Xaluprine therapy (see section 4.4).
Danish: Da der foreligger dokumentation in vitro for, at aminosalicylatderivater (f.eks. olsalazin, mesalazin eller sulfazalazin) hæmmer TPMT-enzymet, som metaboliserer 6-mercaptopurin, skal disse administreres med forsigtighed til patienter, som får samtidig behandling med Xaluprine (se pkt.