FrancophonIA/ELRC3.0 huggingface dataset:
English: These lesions were not observed in macaques; decreases in serum potassium due to hydrochlorothiazide and partly prevented when hydrochlorothiazide was given in combination with irbesartan.
Danish: Disse læsioner blev ikke observeret hos makakaber;  et fald i serum-kalium på grund af hydrochlorthiazid og delvis forebyggelse, når hydrochlorthiazid blev givet i kombination med irbesartan.
English: 56 x 1 tablets
Danish: 56 x 1 tabletter:
English: Antidiabetic medicinal products (oral agents and insulins): dosage adjustment of the antidiabetic medicinal product may be required (see section 4.4);
Danish: Antidiabetika (orale stoffer og insuliner): Det kan være nødvendigt at dosisjustere den antidiabetiske behandling (se pkt.
English: There were 0.6% and 0% of patients with hypotension and 2.8% and 3.1% of patients with dizziness as adverse reactions reported in the combination and monotherapy groups, respectively.
Danish: Henholdsvis 0,6% og 0% af patienterne oplevede hypotension og henholdsvis 2,8% og 3,1% oplevede svimmelhed i ved kombinationsbehandling og enkeltstofbehandling.
English: Cardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interest (hyperkalaemia, hypotension and renal dysfunction) were more frequently reported in the aliskiren group than in the placebo group.
Danish: Kardiovaskulær død og stroke var begge numerisk hyppigere i aliskirengruppen end i placebogruppen og bivirkninger og alvorlige bivirkninger (hyperkaliæmi, hypotension og nedsat nyrefunktion) var hyppigere rapporteret i aliskiren-gruppen end i placebogruppen.
English: Other interactions: the hyperglycaemic effect of beta-blockers and diazoxide may be enhanced by thiazides.
Danish: Andre interaktioner: Den hyperglykæmiske effekt af beta-blokkere og diazoxid kan forstærkes af thiazider.
English: While hydrochlorothiazide is a sulfonamide, only isolated cases of acute angleclosure glaucoma have been reported so far with hydrochlorothiazide.
Danish: Selvom hydrochlorthiazid er et sulfonamid, er der kun rapporteret om isolerede tilfælde af akut snævervinklet glaukom med hydrochlorthiazid.
English: One study included a population comprised of 71,533 cases of BCC and of 8,629 cases of SCC matched to 1,430,833 and 172,462 population controls, respectively.
Danish: Et studie omfattede en population med 71.533 tilfælde af basalcellekarcinom og 8.629 tilfælde af placecellekarcinom, der blev matchet med hhv. 1.430.833 og 172,462 forsøgspersoner i kontrolgrupper.
English: What you need to know before you take CoAprovel
Danish: Det skal du vide, før du begynder at tage CoAprovel
English: If a readministration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA.
Danish: Hvis det er nødvendigt at genoptage diuretika-behandlingen, anbefales det at beskytte udsatte områder mod sol og kunstige UVA-stråler.
English: Diuretic agents such as the hydrochlorothiazide contained in CoAprovel may have an effect on other medicines.
Danish: Vanddrivende stoffer som hydrochlorthiazider, der findes i CoAprovel, kan påvirke anden medicin.
English: Since CoAprovel contains hydrochlorothiazide, it is not recommended during the first trimester of pregnancy.
Danish: CoAprovel indeholder hydrochlorthiazid og kan derfor ikke anbefales under graviditetens første trimester.
English: Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e.g. potassium) in your blood at regular intervals.
Danish: Din læge vil måske regelmæssigt kontrollere din nyrefunktion, dit blodtryk og mængden af elektrolytter (f.eks. kalium) i dit blod.
English: Lithium: reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin converting enzyme inhibitors.
Danish: Lithium: Der er blevet rapporteret reversibel øgning af serum-lithiumkoncentrationer og toksicitet ved samtidig administration af lithium og angiotensin-konverterende enzymhæmmere.
English: CoAprovel can be taken once daily, with or without food.
Danish: CoAprovel kan administreres 1 gang dagligt med eller uden samtidig fødeindtagelse.
English: It is expected to block all actions of angiotensin-II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin-II.
Danish: Stoffet antages at blokere alle virkninger af angiotensin-II, som bliver medieret af AT1 receptoren, uafhængigt af angiotensin-II-syntesens kilde eller rute.
English: NDMA Limit in ng/day
Danish: NDMA Grænseværdi (ng/dag)
English: CoAprovel will usually be prescribed by your doctor when your previous treatment did not reduce your blood pressure enough.
Danish: Lægen vil sandsynligvis starte behandling med CoAprovel, hvis den tidligere behandling ikke sænkede dit blodtryk tilstrækkeligt.
English: Other antihypertensive agents: the antihypertensive effect of CoAprovel may be increased with the concomitant use of other antihypertensive agents.
Danish: Andre antihypertensive stoffer: CoAprovels antihypertensive virkning kan øges ved samtidig administration af andre antihypertensive stoffer.
English: jaundice (intrahepatic cholestatic jaundice)
Danish: Gulsot (intrahepatisk kolestatisk gulsot)
English: Side effects reported in clinical studies for patients treated with CoAprovel were:
Danish: Følgende bivirkninger er indberettet i medicinske forsøg med patienter, som fik CoAprovel:
English: anaphylactic reactions, toxic epidermal necrolysis, necrotizing angitis (vasculitis, cutaneous vasculitis), cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, photosensitivity reactions, rash, urticaria
Danish: Anafylaktiske reaktioner, toksisk epidermal nekrolyse, nekrotiserende angitis (vasculitis, kutan vasculitis), kutan lupus erythematosus-lignende reaktioner, reaktivering af kutan lupus erythematosus, fotosensitivitetsreaktioner, udslæt, urticaria
English: jaundice hepatitis, abnormal liver function
Danish: Gulsot Hepatitis, abnorm leverfunktion
English: A cumulative dose-response relationship was demonstrated with an adjusted OR 2.1 (95% CI: 1.7-2.6) increasing to OR 3.9 (3.0-4.9) for high use (~25,000 mg) and OR 7.7 (5.7-10.5) for the highest cumulative dose (~100,000 mg) (see also section 4.4).
Danish: Der blev påvist en kumulativ dosis/respons relation med en justeret OR-værdi på 2,1 (95 %-KI: 1,7-2,6), der steg til OR 3,9 (3,0- 4,9) ved et stort forbrug (~25.000 mg) og OR 7,7 (5,7-10,5) ved den højeste kumulative dosis (~100.000 mg) (se også pkt.
English: ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both.
Danish: ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) var et studie designet til at undersøge fordele ved at tilføje aliskiren til en standardbehandling med en ACE-hæmmer eller en angiotensin-II-receptorblokker hos patienter med type 2 diabetes mellitus og kronisk nyresygdom, kardiovaskulærsygdom eller begge.
English: Due to the hydrochlorothiazide contained in CoAprovel, if you drink alcohol while on treatment with this medicine, you may have an increased feeling of dizziness on standing up, specially when getting up from a sitting position.
Danish: Hvis du drikker alkohol, mens du er i behandling med dette produkt, kan du opleve, at du bliver mere svimmel, især når du rejser dig op fra siddende stilling.
English: Preparations containing lithium should not be taken with CoAprovel without close supervision by your doctor.
Danish: Tag ikke medicin, der indeholder lithium, samtidig med at du tager CoAprovel uden grundig vejledning fra lægen.
English: CoAprovel contains lactose.
Danish: CoAprovel indeholder lactose
English: impaired renal function including isolated cases of renal failure in patients at risk (see section 4.4)
Danish: Nedsat nyrefunktion inklusive isolerede tilfælde af nyresvigt hos risikopatienter (se pkt.
English: CoAprovel is a combination of an angiotensin-II receptor antagonist, irbesartan, and a thiazide diuretic, hydrochlorothiazide.
Danish: CoAprovel er en kombination af en angiotensin-II receptorantagonist, irbesartan, og et thiaziddiuretikum, hydrochlorthiazid.
English: Irbesartan and hydrochlorothiazide (at doses up to 300 mg irbesartan/25 mg hydrochlorothiazide) have been safely administered with other antihypertensive agents including calcium channel blockers and beta-adrenergic blockers.
Danish: Irbesartan og hydrochlorthiazid (i doser på op til 300 mg irbesartan/25 mg hydrochlorthiazid) er administreret samtidig med andre antihypertensive stoffer, inklusive calcium-blokkere og beta-adrenerge blokkere, uden problemer.
English: Metabolic and endocrine effects: thiazide therapy may impair glucose tolerance.
Danish: Metabolisk og endokrin virkning: Thiazidbehandling kan svække glukosetolerancen.
English: Thiazides may decrease urinary calcium excretion and cause an intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism.
Danish: Thiazider kan sænke urin-calciumudskillelsen og forårsage intermitterende og let forhøjelse af serumcalcium uden kendte forstyrrelser af calciummetabolismen.
English: 4.6 Fertility, pregnancy and lactation Pregnancy
Danish: 4.6 Fertilitet, graviditet og amning Graviditet
English: Adequate monitoring of serum potassium in patients at risk is recommended.
Danish: Adækvat monitorering af serumkalium anbefales hos patienter i risikogruppen.
English: 30 - 56 x 1 - 90 tablets
Danish: 30 - 56 x 1 - 90 tabletter:
English: Not known (frequency cannot be estimated from the available data): skin and lip cancer (nonmelanoma skin cancer).
Danish: Ikke kendt (kan ikke estimeres ud fra forhåndenværende data): Hud- og læbekræft (non-melanom hudkræft).
English: Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy: as with other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or obstructive hypertrophic cardiomyopathy.
Danish: Aorta- og mitralklapstenose, obstruktiv hypertrofisk kardiomyopati: Som ved behandling med andre vasodilatorer skal der udvises ekstra forsigtighed hos patienter, der lider af aorta- eller mitralstenose eller obstruktiv hypertrofisk kardiomyopati.
English: Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists.
Danish: Irbesartan tilhører en medicingruppe der kaldes angiotensin-II receptorantagonister.
English: decreases in serum potassium and sodium
Danish: Fald i serum kalium og natrium
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Danish: Spædbørn, hvis mødre har taget AIIRAer skal observeres omhyggeligt for hypotension (se pkt.
English: Colestyramine and Colestipol resins: absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Danish: Colestyramin og colestipolresiner: Absorption af hydrochlorthiazid nedsættes ved tilstedeværelse af anione resiner.
English: You may need to have blood checks if you take: potassium supplements salt substitutes containing potassium potassium sparing medicines or other diuretics (water tablets) some laxatives medicines for the treatment of gout therapeutic vitamin D supplements medicines to control heart rhythm medicines for diabetes (oral agents or insulins) carbamazepine (a medicine for the treatment of epilepsy).
Danish: Det kan være nødvendigt at tage blodprøver, hvis du tager: kaliumtilskud salterstatninger, der indeholder kalium kalium-besparende medicin eller andre vanddrivende midler visse afføringsmidler medicin til behandling af urinsyregigt terapeutisk vitamin D-tilskud medicin til kontrol af hjerterytmen medicin for sukkersyge (tabletter eller insulin) carbamazepin (medicin, der bruges mod epilepsi)
English: Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på æsken og blisterpakningen efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Sanofi Winthrop Industrie 1 rue de la Vierge Ambarès & Lagrave F-33565 Carbon Blanc Cedex France
Danish: Sanofi Winthrop Industrie 1 rue de la Vierge Ambarès & Lagrave F-33565 Carbon Blanc Cedex Frankrig
English: Non-steroidal anti-inflammatory drugs: when angiotensin II antagonists are administered simultaneously with non-steroidal anti- inflammatory drugs (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Danish: Nonsteroide antiinflammatoriske lægemidler: Når angiotensin II-antagonister administreres samtidig med nonsteroide antiinflammatoriske lægemidler (fx selektive COX-2-hæmmere, acetylsalicylsyre (> 3 g/dag) og non-selektive NSAID) kan den antihypertensive virkning svækkes.
English: Cases of photosensitivity reactions have been reported with thiazides diuretics (see section 4.8).
Danish: Der er rapporteret fotosensitivitetsreaktioner med thiazid-diuretika (se pkt.
English: Forty-seven percent (47.2%) of patients on the combination achieved trough SeDBP < 90 mmHg compared to 33.2% of patients on irbesartan (p = 0.0005).
Danish: 47,2% af patienterne i kombinationsbehandling nåede et dal-SeDBT < 90 mmHg sammenlignet med 33,2% af patienterne behandlet med irbesartan (p = 0,0005).
English: Nondepolarizing skeletal muscle relaxants (e.g. tubocurarine): the effect of nondepolarizing skeletal muscle relaxants may be potentiated by hydrochlorothiazide;
Danish: Nondepolariserende skelet/muskel-relaksanter (fx tubocurarin): Virkningen af nondepolariserende skelet/muskel-relaxanter kan forstærkes af hydrochlorthiazid;
English: The effects of the irbesartan/hydrochlorothiazide combination on fertility have not been evaluated in animal studies, as there is no evidence of adverse effect on fertility in animals or humans with either irbesartan or hydrochlorothiazide when administered alone.
Danish: Effekten af irbesartan/hydrochlorthiazid på fertilitet er ikke evalueret i dyrestudier, da der ikke har været tegn på skadelig effekt på fertiliteten hos dyr eller mennesker med de individuelle stoffer.
English: ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage.
Danish: ONTARGET var et studie i patienter med kardiovaskulær eller cerebrovaskulær sygdom eller type 2 diabetes mellitus in anamnesen med tegn på en organpåvirkning.
English: Table 2: Adverse reactions reported with the use of irbesartan alone
Danish: Tabel 2: Bivirkninger rapporteret ved anvendelse af irbesartan alene
English: No significant pharmacokinetic or pharmacodynamic interactions were observed when irbesartan was coadministered with warfarin, a medicinal product metabolised by CYP2C9.
Danish: Der er ikke observeret signifikante farmakokinetiske eller farmakodynamiske interaktioner ved samtidig administration af irbesartan og warfarin, et lægemiddel som metaboliseres af CYP2C9.
English: The two active ingredients in CoAprovel work together to lower blood pressure further than if either was given alone.
Danish: Når de to aktive stoffer i CoAprovel gives samtidigt, er deres effekt på blodtrykket større, end hvis de blev givet hver for sig.
English: Non-melanoma skin cancer:
Danish: Non-melanom hudkræft:
English: fatigue
Danish: Træthed
English: Increases in cholesterol and triglyceride levels have been associated with thiazide diuretic therapy; however at the 12.5 mg dose contained in CoAprovel, minimal or no effects were reported.
Danish: Thiazidbehandling er associeret med forhøjede kolesterol- og triglycerid-niveauer, Der er dog rapporteret minimal eller ingen effekt ved en dosis på 12,5 mg som findes i CoAprovel.
English: Sanofi Winthrop Industrie 30-36, avenue Gustave Eiffel, BP 7166 F-37071, 37100 Tours France
Danish: Sanofi Winthrop Industrie 30-36, avenue Gustave Eiffel, BP 7166 F-37071, 37100 Tours Frankrig
English: Thiazides may increase the risk of adverse effects caused by amantadine.
Danish: Thiazider kan øge risikoen for bivirkninger forårsaget af amantidin.
English: sanofi-aventis groupe 54, rue La Boétie F-75008 Paris - France
Danish: sanofi-aventis groupe 54, rue La Boétie, F-75008 Paris - Frankrig
English: If calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) must be prescribed, serum calcium levels should be monitored and calcium dosage adjusted accordingly;
Danish: Hvis der gives calciumsupplement eller calciumbesparende lægemiddel (fx D-vitamin), skal serum-calcium måles, og calcium-dosis justeres herefter;
English: General disorders and administration site conditions:
Danish: Almene symptomer og reaktioner på administrationsstedet:
English: In non-clinical safety studies, high doses of irbesartan (≥ 250 mg/kg/day in rats and ≥ 100 mg/kg/day in macaques) caused a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit).
Danish: I prækliniske sikkerhedsstudier medførte store doser irbesartan (≥ 250 mg/kg/dag hos rotter og ≥ 100 mg/kg/dag hos makakaber) en reduktion i røde blodlegemeparametre (erytrocytter, hæmoglobin, hæmatokrit).
English: As with any antihypertensive agent, excessive blood pressure decrease in patients with ischemic cardiopathy or ischemic cardiovascular disease could result in a myocardial infarction or stroke.
Danish: Ved behandling med et antihypertensivt stof kan en voldsom sænkning af blodtrykket hos patienter med iskæmisk kardiopati eller iskæmisk kardiovaskulær sygdom medføre myokardieinfarkt eller slagtilfælde.
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypokalaemia, hyponatraemia, and hypochloremic alkalosis).
Danish: Thiazider, inklusive hydrochlorthiazid, kan medføre væske- eller elektrolytforstyrrelser (hypokaliæmi, hyponatriæmi og hypokloræmisk alkalose).
English: Lithium: the combination of lithium and CoAprovel is not recommended (see section 4.5).
Danish: Lithium: Kombination af lithium og CoAprovel frarådes (se pkt.
English: The active substances are irbesartan and hydrochlorothiazide.
Danish: De aktive stoffer er irbesartan og hydrochlorthiazid.
English: Acute Myopia and Secondary Acute Angle-Closure Glaucoma: sulfonamide drugs or sulfonamide derivative drugs can cause an idiosyncratic reaction, resulting in transient myopia and acute angleclosure glaucoma.
Danish: Akut myopi og sekundært snævervinklet glaukom: Brug af lægemidler, der indeholder sulfonamid eller et sulfonamidderivat, kan medføre en idiosynkratiske reaktion, som kan forårsage forbigående myopi og akut snævervinklet glaukom.
English: Ear and labyrinth disorders:
Danish: Øre og labyrint:
English: Irbesartan exhibits linear and dose proportional pharmacokinetics over the dose range of 10 to 600 mg. A less than proportional increase in oral absorption at doses beyond 600 mg was observed; the mechanism for this is unknown.
Danish: Irbesartan udviser lineær og dosisproportionel farmakokinetik i et dosisinterval på 10-600 mg. Der blev observeret en mindre end proportional øgning af oral absorption ved doser over 600 mg (2 gange den maksimale anbefalede dosis).
English: fever
Danish: Feber
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu/
Danish: Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu.
English: If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take CoAprovel” and “Warnings and precautions”).
Danish: Din læge kan blive nødt til at ændre din dosis og/eller tage andre forholdsregler: Hvis du tager en ACE-hæmmer eller aliskiren (se også information under ”Tag ikke CoAprovel” og ”Advarsler og forsigtighedsregler”).
English: ACE-inhibitors and angiotensin II receptor blockers should therefore not be used concomitantly in patients with diabetic nephropathy.
Danish: ACE-hæmmere og angiotensin-II-receptorblokkere bør derfor ikke anvendes samtidig hos patienter med diabetisk nefropati.
English: Renal impairment and kidney transplantation: when CoAprovel is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid serum levels is recommended.
Danish: Nedsat nyrefunktion og nyretransplantation: Når CoAprovel anvendes til patienter med nedsat nyrefunktion, anbefales periodisk monitorering af serum-kalium, serum-kreatinin og serum-urinsyreniveauer.
English: SANOFI WINTHROP INDUSTRIE 30-36 Avenue Gustave Eiffel 37100 Tours - France
Danish: SANOFI WINTHROP INDUSTRIE 30-36 Avenue Gustave Eiffel 37100 Tours - Frankrig
English: The frequency of the side effects listed below is defined using the following convention: Common: may affect up to 1 in 10 people
Danish: Hyppigheden af nedenstående bivirkninger er angivet på følgende måde: Almindelig: kan påvirke op til 1 ud af 10 patienter Ikke almindelig: kan påvirke op til 1 ud af 100 patienter
English: The use of AIIRAs is not recommended during the first trimester of pregnancy (see section 4.4).
Danish: AIIRAer bør ikke anvendes under graviditetens første trimester (se pkt.
English: Tables 2 and 3 below detail the adverse reactions reported with the individual components of CoAprovel.
Danish: Tabel 2 og 3 viser bivirkningerne af de individuelle stoffer i CoAprovel.
English: No dosage adjustment of CoAprovel is necessary in older people.
Danish: Dosisjustering af CoAprovel til ældre personer er ikke nødvendig.
English: Furthermore, renal clearance of lithium is reduced by thiazides so the risk of lithium toxicity could be increased with CoAprovel.
Danish: Derudover reducerer thiazider nyreclearance af lithium og dermed øges risikoen for lithium toksicitet ved behandling med CoAprovel.
English: The use of AIIRAs is contraindicated during the second and third trimesters of pregnancy (see sections 4.3 and 4.4).
Danish: Anvendelsen af AIIRA er kontraindiceret under graviditetens anden og tredje trimester (se pkt.
English: No teratogenic effects were seen in rats given irbesartan and hydrochlorothiazide in combination at doses that produced maternal toxicity.
Danish: Der er ikke set tegn på teratogen effekt hos rotter, der fik kombination af irbesartan og hydrochlorthiazid i doser, som forårsager maternel toksicitet.
English: Calcium salts: thiazide diuretics may increase serum calcium levels due to decreased excretion.
Danish: Calciumsalte: Thiaziddiuretika kan øge serum-calcium niveauet på grund af nedsat udskillelse.
English: There is no clinical experience with CoAprovel in patients with hepatic impairment.
Danish: Der er ingen klinisk erfaring med CoAprovel hos patienter med nedsat leverfunktion.
English: This fixed dose combination is indicated in adult patients whose blood pressure is not adequately controlled on irbesartan or hydrochlorothiazide alone (see section 5.1).
Danish: Denne faste dosiskombination er indiceret til voksne patienter, hvis blodtryk ikke kan reguleres adækvat med irbesartan eller hydrochlorthiazid alene (se pkt.
English: Electrolyte imbalance: as for any patient receiving diuretic therapy, periodic determination of serum electrolytes should be performed at appropriate intervals.
Danish: Elektrolytforstyrrelser: Som for alle patienter i diuretisk behandling, skal der med passende mellemrum foretages periodisk kontrol af serum-elektrolytter.
English: Excipients: also contains lactose monohydrate.
Danish: Hjælpestoffer: indeholder også lactosemonohydrat.
English: transient blurred vision, xanthopsia, acute myopia and secondary acute angle-closure glaucoma
Danish: Forbigående sløret syn, xanthopsia, akut myopi og sekundært snævervinklet glaukom