FrancophonIA/ELRC3.0 huggingface dataset:
English: Trizivir contains abacavir, lamivudine and zidovudine, therefore any interactions identified for these individually are relevant to Trizivir.
Croatian: Budući da Trizivir sadrži abakavir, lamivudin i zidovudin, bilo koja interakcija koja je ustanovljena s ovim lijekovima pojedinačno relevantna je za Trizivir.
English: Very common side effects These may affect more than 1 in 10 people:
Croatian: Vrlo rijetke nuspojave Mogu se javiti u manje od 1 na 10 000 osoba:
English: When these people start treatment, they may find that old, hidden infections flare up, causing signs and symptoms of inflammation.
Croatian: Kada takvi bolesnici započinju liječenje može se dogoditi da dođe do ponovne aktivacije starijeg, do tada skrivenog upalnog procesa koji može uzrokovati znakove i simptome upale.
English: Because Trizivir contains abacavir, lamivudine and zidovudine, the adverse reactions associated with these compounds may be expected.
Croatian: Budući da Trizivir sadrži abakavir, lamivudin i zidovudin, mogu se očekivati nuspojave karakteristične za te spojeve.
English: Before initiating abacavir therapy, clinicians should screen for HLA-B*5701.
Croatian: Prije početka liječenja abakavirom, kliničari moraju napraviti probir na HLA-B*5701.
English: It is recommended that treatment is started with abacavir, lamivudine, and zidovudine separately for the first 6-8 weeks (see section 4.4).
Croatian: Preporučuje se započeti liječenje s odvojenim abakavirom, lamivudinom i zidovudinom tijekom prvih 6-8 tjedana
English: There are no data available on treatment with the combination of abacavir, lamivudine and zidovudine in animals.
Croatian: Nema dostupnih podataka o učincima kombinacije abakavira, lamivudina i zidovudina u životinja.
English: Currently there are no data on the use of Trizivir in heavily pre-treated patients, patients failing on other therapies or patients with advanced disease (CD4 cells < 50 cells/mm3).
Croatian: Ne postoje podaci o uporabi lijeka Trizivir u bolesnika koju ranije primali jaku terapiju, bolesnika kod kojih druge terapije nisu bile uspješne kao i bolesnika s uznapredovalom bolešću (CD4 stanice
English: Lamivudine is predominately cleared by renal excretion of unchanged lamivudine.
Croatian: Lamivudin se najvećim dijelom uklanja izlučivanjem renalnim putem u nepromijenjenom obliku.
English: Common: rash (without systemic symptoms) Very rare: erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis
Croatian: Vrlo rijetko: eritema multiforme, Stevens-Johnsonov sindrom i toksična epidermalna nekroliza
English: GlaxoSmithKline Pharmaceuticals S.A., ul.
Croatian: ili GlaxoSmithKline Pharmaceuticals S.A., ul.
English: Potential to slightly decrease zidovudine plasma concentrations through UGT induction.
Croatian: Mogućnost blagog sniženja koncentracije zidovudina u plazmi zbog UGT indukcije.
English: URICOSURIC Probenecid/Abacavir
Croatian: URIKOZURICI probenecid/abakavir
English: Trizivir was shown to be bioequivalent to abacavir 300 mg, lamivudine 150 mg and zidovudine 300 mg given as separate tablets for AUC0-∞ and Cmax.
Croatian: Pokazano je da je Trizivir bioekvivalentan abakaviru 300 mg, lamivudinu 150 mg i zidovudinu 300 mg koji su primijenjeni kao odvojene tablete za vrijednosti AUC0-∞ i Cmax.
English: Some people taking Trizivir are more at risk of serious side effects.
Croatian: Trizivir su pod većim rizikom od razvoja ozbiljnih nuspojava.
English: • tingly feelings in the skin (pins and needles)
Croatian: • osjećaj trnaca u koži (kao bockanje iglicama)
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER x 60 FILM-COATED TABLETS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP BLISTER x 60 FILMOM OBLOŽENIH
English: • vincristine, vinblastine or doxorubicin, to treat cancer Tell your doctor if you're taking any of these.
Croatian: • vinkristin, vinblastin ili doksorubicin, za liječenje raka.
English: What Trizivir looks like and contents of the pack Trizivir film-coated tablets are engraved with ‘GX LL1' on one side.
Croatian: Trizivir filmom obložene tablete imaju na jednoj strani utisnutu oznaku ‘GX LL1'.
English: In a meta-analysis of six clinical trials, TAMs were not selected by regimens containing abacavir without zidovudine (0/127), but were selected by regimens containing abacavir and the thymidine analogue zidovudine
Croatian: U metaanalizi 6 kliničkih ispitivanja selekcije mutacija analoga timidina nisu utvrđene u režimima liječenja koji su uključivali abakavir bez zidovudina (0/127), ali jesu u režimima liječenja koji su uključivali abakavir i analog timidina zidovudin (22/86, 26%).
English: Additionally, dose adjustment of zidovudine may be required if severe anaemia or myelosuppression occurs during treatment with Trizivir, or in patients with pre-existing bone marrow compromise e.g. haemoglobin < 9 g/dl (5.59 mmol/l) or neutrophil count < 1.0 x 109/l (see section 4.2).
Croatian: Potreba za prilagođavanjem doze zidovudina se može javiti u slučaju pojave teške anemije ili mijelosupresije u bolesnika liječenih lijekom Trizivir ili u bolesnika s prethodnom bolešću koštane srži, tj. s vrijednošću hemoglobina < 9 g/dl (5,59 mmol/l) ili brojem neutrofila < 1,0 x 109/l (vidjeti dio 4.2).
English: Methadone/Zidovudine (30 to 90 mg once daily/200 mg every 4 hours)
Croatian: metadon/zidovudin (30 do 90 mg jednom dnevno/200 mg svaka 4 sata)
English: In vivo resistance (Therapy experienced patients)
Croatian: Rezistencija in vivo (prethodno neliječeni bolesnici)
English: • passing urine more often
Croatian: • češće mokrenje
English: Potential to slightly decrease abacavir plasma concentrations through UGT induction.
Croatian: Mogućnost blagog sniženja koncentracije abakavira u plazmi zbog UGT indukcije.
English: Before initiating treatment with abacavir, screening for carriage of the HLA-B*5701 allele should be performed in any HIV-infected patient, irrespective of racial origin(see section 4.4).
Croatian: Prije započinjanja liječenja abakavirom za svakog bolesnika zaraženog HIV-om, bez obzira na rasno podrijetlo, mora se odrediti je li nositelj alela HLA-B*5701 (vidjeti dio 4.4).
English: These may affect up to 1 in 1000 people:
Croatian: Mogu se javiti u manje od 1 na 1000 osoba:
English: MARKETING AUTHORISATION HOLDER ViiV Healthcare BV
Croatian: Nositelj odobrenja za stavljanje lijeka u promet ViiV Healthcare BV
English: The 5'-glucuronide of zidovudine is the major metabolite in both plasma and urine, accounting for approximately 50 - 80 % of the administered dose eliminated by renal excretion.
Croatian: Glavni metabolit zidovudina u plazmi i urinu je 5'-glukuronid i u tom se obliku putem bubrega izlučuje približno 50 - 80% primijenjene doze lijeka.
English: These may affect up to 1 in 100 people:
Croatian: Mogu se javiti u manje od 1 na 100 osoba:
English: Other possible side effects of Trizivir
Croatian: Ostale moguće nuspojave lijeka Trizivir
English: Abacavir has a weak potential to cause chromosomal damage both in vitro and in vivo at high test concentrations and therefore any potential risk to man must be balanced against the expected benefits of treatment.
Croatian: Ispitivanja su pokazala da visoke koncentracije abakavira danih in vitro i in vivo imaju slabi potencijal za izazivanje kromosomskih oštećenja te stoga treba odvagati potencijalni rizik za bolesnika u odnosu na očekivane učinke terapije.
English: The concomitant use of ribavirin with zidovudine is not recommended due to an increased risk of anaemia (see section 4.4).
Croatian: Istovremena primjena ribavirina sa zidovudinom nije preporučena zbog povišenog rizika od anemije (vidjeti dio 4.4).
English: Rare: pancreatitis
Croatian: proljev Rijetko: pankreatitis
English: However, it is not clear whether these cases were due to treatment with these medicinal products or to the underlying HIV disease.
Croatian: Međutim, nije u potpunosti razjašnjeno je li pankreatitis u tom slučaju posljedica uzimanja antivirusne terapije ili same HIV bolesti.
English: At week 48 the proportion of subjects with HIV RNA <50 copies/ml were 63 %, 80 % and 86 % for the ZDV/3TC/ABC, ZDV/3TC/EFV and ZDV/3TC/ABC/EFV arms, respectively.
Croatian: slijedom navođenja bio je 63%, 80% i 86% za terapijske skupine ZDV/3TC/ABC, ZDV/3TC/EFV i ZDV/3TC/ABC/EFV.
English: If the doctor thinks they may have been related, you will be told never again to take Trizivir, or any other medicine containing abacavir (Kivexa,Triumeq or Ziagen).
Croatian: Ako liječnik misli da bi mogli biti povezani, reći će Vam da više nikad ne uzimate Trizivir ili bilo koji drugi lijek koji sadrži abakavir (npr. Kivexa, Triumeq ili Ziagen).
English: Number of subjects with ≥1 TAM. TAMs might be selected when thymidine analogs are associated with abacavir.
Croatian: Do selekcije mutacije analoga timidina (TAMs) može doći kad su analozi timidina povezani s abakavirom.
English: CONTACT YOUR DOCTOR IMMEDIATELY for advice on whether you should stop taking Trizivir if:
Croatian: ODMAH SE JAVITE SVOM LIJEČNIKU koji će Vam savjetovati trebate li prestati uzimati Trizivir ako: 1) dobijete osip po koži ILI
English: The concomitant use of ribavirin with zidovudine is not recommended due to an increased risk of anaemia (see section 4.5).
Croatian: Istodobna uporaba ribavirina i zidovudina se ne preporučuje zbog povećanog rizika od razvoja anemije (vidjeti dio 4.5).
English: Trizivir is contraindicated in patients with end-stage renal disease (see section 4.3).
Croatian: Trizivir je kontraindiciran u bolesnika s terminalnim zatajenjem bubrega (vidjeti dio 4.3).
English: Abacavir is primarily metabolised by the liver with approximately 2 % of abacavir excreted unchanged in the urine.
Croatian: Abakavir se primarno metabolizira putem jetre, a približno 2% se izlučuje urinom u nepromijenjenom obliku.
English: Very common: headache Common: dizziness Rare: insomnia, paraesthesia, somnolence, loss of mental acuity, convulsions
Croatian: Rijetko: nesanica, parestezije, somnolencija, gubitak mentalne oštrine, konvulzije
English: Malignant tumours occurred in the preputial gland of males and the clitoral gland of females of both species, and in rats in the thyroid gland of males and and in the liver, urinary bladder, lymph nodes and the subcutis of females.
Croatian: Maligni tumori javljali su se na prepucijskoj žlijezdi u mužjaka i klitoralnoj žlijezdi u ženki obje vrste, te u štakora na štitnoj žlijezdi mužjaka te u jetri,
English: You need to be aware of the extra risks:
Croatian: koja predstavlja važan identificirani rizik:
English: Abacavir, lamivudine and zidovudine are not significantly metabolised by cytochrome P450 enzymes (such as CYP 3A4, CYP 2C9 or CYP 2D6) nor do they inhibit or induce this enzyme system.
Croatian: (poput CYP 3A4, CYP 2C9 ili CYP 2D6) niti pokazuju utjecaj na inhibiciju ili indukciju tog sustava enzima.
English: Trizivir contains abacavir (which is also an active substance in Kivexa, Triumeq and Ziagen).
Croatian: Trizivir sadrži abakavir (koji je također djelatna tvar u lijekovima Kivexa, Triumeq i Ziagen).
English: renal impairment (See Section
Croatian: funkcije bubrega (vidjeti dio
English: ANTI-INFECTIVE PRODUCTS Atovaquone/Abacavir
Croatian: ANTIINFEKTIVNI LIJEKOVI atovakon/abakavir
English: The remaining arms were continued in a blinded fashion.
Croatian: Ostale terapijske skupine nastavile su se ispitivati u slijepim uvjetima.
English: Common: myalgia Uncommon: myopathy
Croatian: Često: mialgija Manje često: miopatija
English: In a second study, mice were administered zidovudine at doses up to 40 mg/kg for 24 months, with exposure beginning prenatally on gestation day 10.
Croatian: U drugom ispitivanju su miševima u razdoblju od 24 mjeseca davali zidovudin u dozama do 40 mg/kg,
English: Clarithromycin/Lamivudine Interaction not studied.
Croatian: valproična kiselina/lamivudin Nema studija interakcije.
English: Abacavir should not be used in patients known to carry the HLA-B*5701 allele.
Croatian: Abakavir se ne smije primijeniti u bolesnika za koje se zna su nositelji alela HLA-B*5701.
English: Abacavir is metabolised primarily by the liver.
Croatian: Abakavir se primarno metabolizira u jetri.
English: Clarithromycin/Zidovudine (500 mg twice daily/100 mg every 4 hours)
Croatian: klaritromicin/zidovudin (500 mg dva puta na dan/100 mg svaka 4 sata)
English: Abacavir is primarily metabolised by the liver with approximately 2 % of the administered dose being renally excreted, as unchanged compound.
Croatian: Abakavir se primarno metabolizira u jetri, a oko 2% primijenjene doze izlučuje se putem bubrega u nepromijenjenom obliku.
English: Zidovudine has not been shown to affect the number of sperm, sperm morphology and motility in man.
Croatian: U muškaraca nije pokazano da primjena zidovudina ima utjecaj na broj, morfologiju ili pokretljivost spermija.
English: Common: raised blood levels of liver enzymes and bilirubin Rare: liver disorders such as severe hepatomegaly with steatosis,
Croatian: Rijetko: poremećaji jetre poput teške hepatomegalije sa steatozom,
English: When possible, avoid chronic coadministration of Trizivir with medicinal products containing sorbitol or other osmotic acting poly-alcohols or monosaccharide alcohols (e.g. xylitol, mannitol, lactitol, maltitol).Consider more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided.
Croatian: Kada je moguće, izbjegavajte dugotrajnu istodobnu primjenu lijeka Trizivir i lijekova koji sadrže sorbitol ili neki drugi polialkohol ili monosaharidni alkohol s osmotskim djelovanjem (npr. ksilitol, manitol, laktitol, maltitol).
English: The active ingredients of Trizivir may inhibit cellular DNA replication, zidovudine has been shown to be transplacental carcinogen in one animal study and abacavir has been shown to be carcinogenic in animal models (see section 5.3).
Croatian: Djelatne tvari lijeka Trizivir mogu inhibirati replikaciju stanične DNK, a zidovudin se u jednoj studiji na životinjama pokazao kao transplacentalno kancerogen.
English: NAME OF THE MEDICINAL PRODUCT TRIZIVIR 300 mg/150 mg/300 mg film-coated tablets
Croatian: NAZIV LIJEKA TRIZIVIR 300 mg/150 mg/300 mg filmom obložene tablete
English: Special care is advised in this age group due to age associated changes such as the decrease in renal function and alteration of haematological parameters.
Croatian: Zbog promjena povezanih sa starijom dobi poput smanjenja bubrežne funkcije i promjena hematoloških parametara preporučuje se poseban oprez u ovoj dobnoj skupini.
English: Trizivir should not be administered to patients with end-stage renal disease (see sections 4.3 and 5.2).
Croatian: Trizivir se ne smije davati bolesnicima u završnom stadiju bubrežne bolesti (vidjeti dio 4.3 i 5.2).
English: - nausea or vomiting or diarrhoea or abdominal pain
Croatian: - mučnina ili povraćanje, proljev ili bol u trbuhu
English: Other common symptoms are: • nausea (feeling sick), vomiting (being sick), diarrhoea, abdominal (stomach) pain, severe tiredness
Croatian: Ostali česti simptomi su: • mučnina, povraćanje, proljev, bol u trbuhu (abdomenu), izraziti umor.
English: The clinical status of the patient and the adverse event profile of Trizivir should be borne in mind when considering the patient's ability to drive or operate machinery.
Croatian: Kada se razmatra sposobnost bolesnika da vozi ili upravlja strojem, treba imati na umu njegov klinički status i profil nuspojava lijeka Trizivir.
English: Rare: rhabdomyolysis
Croatian: Rijetko: rabdomioliza
English: Physicians should refer to the individual summary of product characteristics of these medicinal products.
Croatian: U tim slučajevima liječnik mora proučiti individualne sažetke opisa svojstava lijeka za te lijekove.
English: If Trizivir is discontinued in patients co-infected with hepatitis B virus, periodic monitoring of both liver function tests and markers of HBV replication is recommended, as withdrawal of lamivudine may result in an acute exacerbation of hepatitis (see Zeffix SmPC).
Croatian: preporučuje se periodičko praćenje testova jetrene funkcije i markera HBV replikacije, budući da prestanak uzimanja lamivudina može izazvati akutnu egzacerbaciju hepatitisa (vidjeti sažetak opisa svojstava lijeka za Zeffix tablete).
English: Phenotypic resistance to abacavir requires M184V with at least one other abacavir-selected mutation, or M184V with multiple TAMs.
Croatian: Fenotipska rezistencija i križna rezistencija: za fenotipsku rezistenciju na abakavir potrebna je mutacija M184V uz najmanje još jednu abakavirom uzrokovanu mutaciju ili mutacija M184V s višestrukim mutacijama analoga timidina.
English: How to store Trizivir
Croatian: Kako čuvati Trizivir
English: SIDE 2
Croatian: 2. STRANA
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 300 mg of abacavir (as sulfate), 150 mg lamivudine and 300 mg zidovudine.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Svaka filmom obložena tableta sadržava 300 mg abakavira (u obliku abakavirsulfata), 150 mg lamivudina i 300 mg zidovudina.
English: • cladribine, used to treat hairy cell leukaemia
Croatian: • kladribin, za liječenje leukemije vlasastih stanica
English: As dose adjustment of Trizivir is not possible, separate preparations of abacavir, lamivudine and zidovudine should be used.
Croatian: Budući da se doza lijeka Trizivir ne može prilagođavati, potrebno je koristiti odvojene pripravke abakavira, lamivudina i zidovudina.
English: The adverse reactions reported with abacavir, lamivudine and zidovudine are presented in Table 2.
Croatian: Nuspojave koje su prijavljene pri korištenju abakavira, lamivudina i zidovudina navedene su u Tablici
English: In addition, the 69 insertion complex or the Q151M mutation, usually found in combination with A62V, V75I, F77L and F116Y, cause a high level of resistance to abacavir.
Croatian: Osim toga, insercijski kompleks na mjestu 69 ili mutacija Q151M , koja se obično nalazi u kombinaciji s A62V,
English: If you have stopped taking Trizivir because of a hypersensitivity reaction, you must NEVER AGAIN take Trizivir, or any other medicine containing abacavir (Kivexa, Triumeq or Ziagen).
Croatian: Ako ste prestali uzimati Trizivir Ako ste prestali uzimati Trizivir zbog reakcije preosjetljivosti, ne smijete VIŠE NIKADA uzimati Trizivir ili bilo koji lijek koji sadrži abakavir (npr. Kivexa, Triumeq ili Ziagen).
English: Clarithromycin/Abacavir
Croatian: klaritromicin/abakavir
English: Limited data in patients with cirrhosis suggest that accumulation of zidovudine may occur in patients with hepatic impairment because of decreased glucuronidation.
Croatian: Ograničeni podaci o bolesnicima s cirozom jetre pokazuju da kod bolesnika s oštećenjem funkcije jetre zbog smanjene glukuronidacije može doći do nakupljanja zidovudina.
English: Tablet Core: microcrystalline cellulose, sodium starch glycollate (type A), magnesium stearate.
Croatian: natrijev škroboglikolat (tipa A), magnezijev stearat.
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited binding to the major plasma protein albumin (< 36 % serum albumin in vitro).
Croatian: Lamivudin pokazuje linearnu farmakokinetiku u rasponu terapijskih doza i ograničeno se veže za glavni protein u plazmi,
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER ViiV Healthcare BV
Croatian: NAZIV NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET ViiV Healthcare BV
English: • a failure of the bone marrow to produce new red blood cells (pure red cell aplasia)
Croatian: • zatajenje stvaranja novih crvenih krvnih stanica iz koštane srži (izolirana aplazija crvenih krvnih stanica).
English: Trizivir is not recommended in patients with moderate or severe hepatic impairment (see sections 4.2 and 5.2).
Croatian: Trizivir se ne preporučuje u bolesnika s umjerenim do teškim oštećenjem funkcije jetre (vidjeti dio 4.2 i 5.2).
English: INFORMATION IN BRAILLE trizivir
Croatian: PODACI NA BRAILLEOVOM PISMU
English: The special warnings and precautions relevant to abacavir, lamivudine and zidovudine are included in this section.
Croatian: U ovom poglavlju navedena su posebna upozorenja i mjere opreza koje se odnose na abakavir, lamivudin i zidovudin.
English: Very common: Nausea Common: vomiting, abdominal pain, and diarrhoea Uncommon: flatulence Rare: oral mucosa pigmentation, taste disturbance dyspepsia, pancreatitis
Croatian: Vrlo često: mučnina Često: povraćanje, bol u abdomenu i proljev Manje često: nadutost Rijetko: pigmentacija sluznice usne šupljine, poremećaj okusa,
English: Delay in stopping treatment with Trizivir after the onset of hypersensitivity may result in a life-threatening reaction.
Croatian: Odgađanje prekida liječenja lijekom Trizivir nakon nastupa preosjetljivosti može uzrokovati trenutačnu i po život opasnu reakciju.
English: One year postnatally, there was an increase in the incidence of tumours in the lung, liver and female reproductive tract of offspring exposed to the highest dose level (420 mg/kg term body weight).
Croatian: Godinu dana po okotu uočen je porast učestalosti neoplazmi pluća, jetre i ženskog reproduktivnog sustava u potomaka izloženih najvišoj dozi
English: Haematological adverse reactions with zidovudine
Croatian: Hematološke nuspojave povezane sa zidovudinom
English: Uncommon: transient rises in liver enzymes (AST, ALT) Rare: hepatitis
Croatian: Manje često: prolazni porast razina jetrenih enzima (AST, ALT)
English: Each film-coated tablet contains: abacavir 300 mg (as sulfate) lamivudine 150 mg zidovudine 300 mg
Croatian: Svaka filmom obložena tableta sadržava: abakavir 300 mg (u obliku abakavirsulfata) lamivudin 150 mg zidovudin 300 mg
English: As dose adjustments of lamivudine and zidovudine may be necessary it is recommended that separate preparations of abacavir, lamivudine and zidovudine be administered to patients with reduced renal function (creatinine clearance ≤ 50 ml/min).
Croatian: Kako se može pokazati potreba za prilagodbom doze lamivudina i zidovudina u bolesnika sa smanjenom funkcijom bubrega (klirens kreatinina ≤ 50 ml /min), kod njih se preporučuje primjena odvojenih pripravaka abakavira, lamivudina i zidovudina.
English: Uncommon: neutropenia, anaemia (both occasionally severe), thrombocytopenia Very rare: pure red cell aplasia
Croatian: Manje često: neutropenija i anemija (obje ponekad teške), trombocitopenija
English: (Co-trimoxazole)/Lamivudine (160mg/800mg once daily for 5 days/300mg single dose)
Croatian: (160 mg/800 mg jedanput dnevno tijekom 5 dana/300 mg jednokratna doza)
English: In patients with high viral load (> 100,000 copies/ml) choice of therapy needs special consideration (see section 5.1).
Croatian: Potrebna je posebna pažnja pri razmatranju odabira terapije u bolesnika s visokim virusnim opterećenjem (> 100 000 kopija/ml)
English: Abacavir is primarily metabolised by the liver.
Croatian: Abakavir se primarno metabolizira putem jetre.
English: Zidovudine AUC ↓48% (UGT induction)
Croatian: zidovudin AUC ↓48% (UGT indukcija) ANTIKONVULZIVNI
English: 3'-amino-3'deoxythymidine (AMT) has been identified as a metabolite of zidovudine following intravenous dosing.
Croatian: Zidovudin se nakon intravenske primjene jednim djelom metabolizira u 3'-amino-3'-deoksitimidin (AMT).
English: RETINOIDS Retinoid compounds (e.g. isotretinoin)/Abacavir
Croatian: RETINOIDI spojevi retinoida (npr. izotretinoin)/abakavir
English: Physicians should refer to the individual prescribing information for these medicinal products.
Croatian: Liječnici trebaju proučiti sažetke opisa svojstava lijeka za svaki od tih lijekova.
English: As dose adjustment of Trizivir is not possible separate preparations of zidovudine, abacavir and lamivudine should be used.
Croatian: Budući da prilagodba doze prilikom uzimanja lijeka Trizivir nije moguća, potrebno je koristiti odvojene pripravke zidovudina, abakavira i lamivudina.
English: Rare: pure red cell aplasia Very rare: aplastic anaemia
Croatian: Vrlo rijetko: izolirana aplazija crvenih krvnih stanica
English: HLA-B*5701 status must always be documented and explained to the patient prior to initiating therapy.
Croatian: status mora uvijek biti dokumentiran i objašnjen bolesniku prije početka liječenja.