FrancophonIA/ELRC3.0 huggingface dataset:
English: The pharmacokinetics of irbesartan were evaluated in 23 hypertensive children after the administration of single and multiple daily doses of irbesartan (2 mg/kg) up to a maximum daily dose of 150 mg for four weeks.
Croatian: Farmakokinetika irbesartana proučavana je tijekom 4 tjedna na 23 djece s hipertenzijom, nakon primjene jednokratne i višekratnih dnevnih doza (2 mg/kg), do maksimalne dnevne doze od 150 mg irbesartana.
English: • The concomitant use of Irbesartan Teva with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5
Croatian: • Istodobna primjena lijeka Irbesartan Teva s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem bubrega (GFR < 60 ml/1,73 m2) (vidjeti dijelove 4.5 i 5.1)
English: The study examined the long-term effects (2 years) of irbesartan on the progression to clinical (overt) proteinuria (urinary albumin excretion rate (UAER) > 300 mg/day, and an increase in UAER of at least 30 % from baseline).
Croatian: U studiji su ispitivani dugotrajni učinci (2 godine) irbesartana na progresiju klinički izražene proteinurije (brzina izlučivanja albumina u mokraću (engl. urinary albumin excretion rate, UAER) >300 mg/dan i porast u vrijednostima UAER najmanje 30% od početnih vrijednosti).
English: Your doctor may need to change your dose and/or to take other precautions: If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take Irbesartan Teva” and “Warnings and precautions”).
Croatian: Liječnik će Vam možda morati promijeniti dozu i/ili poduzeti druge mjere opreza: Ako uzimate neki blokator angiotenzin II receptora (ARB) ili aliskiren (vidjeti također informacije pod naslovima „Nemojte uzimati Irbesartan Teva“ i „Upozorenja i mjere opreza“).
English: Uncommon: sexual dysfunction
Croatian: seksualna disfunkcija
English: Irbesartan Teva contains sodium
Croatian: Irbesartan Teva sadrži natrij
English: No significant pharmacokinetic or pharmacodynamic interactions were observed when irbesartan was coadministered with warfarin, a medicinal product metabolised by CYP2C9.
Croatian: Nisu zabilježene značajne farmakokinetičke i farmakodinamičke interakcije kod istodobne primjene irbesartana i varfarina, lijeka koji se metabolizira pomoću CYP2C9.
English: Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels causing them to tighten.
Croatian: Angiotenzin II tvar je koja se stvara u tijelu i koja se veže na receptore u krvnim žilama te uzrokuje njihovo sužavanje.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Croatian: U svakoj skupini učestalosti nuspojave su prikazane slijedom prema sve manjoj ozbiljnosti.
English: Intravascular volume depletion
Croatian: Smanjenje intravaskularnog volumena
English: Teva GmbH Tel: +49 73140208
Croatian: Deutschland Teva GmbH Tel: +49 73140208
English: Irbesartan Teva is indicated in adults for the treatment of essential hypertension.
Croatian: Irbesartan Teva je indiciran za liječenje esencijalne hipertenzije u odraslih.
English: Pack sizes of 50 x 1 and 56 x 1 film-coated tablet in unit dose blisters.
Croatian: Pakiranja sa 50 x 1 i 56 x 1 filmom obloženom tabletom u blisterima djeljivim na jedinične doze.
English: In a randomised trial of 318 hypertensive children and adolescents aged 6 to 16 years, the following adverse reactions occurred in the 3-week double-blind phase: headache (7.9 %), hypotension (2.2 %), dizziness (1.9 %), cough (0.9 %).
Croatian: U trotjednoj dvostruko-slijepoj fazi randomizirane kliničke studije u koju je bilo uključeno 318 djece i adolescenata s hipertenzijom u dobi od 6 do 16 godina pojavile su se sljedeće nuspojave povezane s primjenom lijeka: glavobolja (7,9%), hipotenzija (2,2%), omaglica (1,9%), kašalj (0,9%).
English: Over a subsequent two week period where patients were re-randomized to either active medicinal product or placebo, patients on placebo had increases of 2.4 and 2.0 mm Hg in SeSBP and SeDBP compared to +0.1 and -0.3 mm Hg changes respectively in those on all doses of irbesartan (see section 4.2).
Croatian: Tijekom sljedeća dva tjedna kada su bolesnici ponovo randomizirani ili na lijek ili na placebo, bolesnici na placebu imali su porast od 2,4 i 2,0 mmHg za SeSBP i SeDBP, u usporedbi s promjenom od +0,1 i -0,3 mmHg za bolesnike na svim dozama irbesartana (vidjeti dio 4.2.).
English: Aliskiren-containing products or ACE-inhibitors
Croatian: Lijekovi koji sadrže aliskiren ili ACE inhibitori
English: 2031GA Haarlem The Netherlands
Croatian: 2031GA Haarlem
English: One side of the tablet debossed with the number “93”.
Croatian: Na jednoj strani tablete je utisnut broj “93”.
English: Rebound hypertension has not been observed.
Croatian: Nije zabilježena pojava veće hipertenzije (tzv. rebound hipertenzija).
English: It is also indicated for the treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus as part of an antihypertensive medicinal product regimen (see sections 4.3, 4.4, 4.5 and 5.1).
Croatian: Također je indiciran za liječenje bubrežne bolesti u odraslih bolesnika s hipertenzijom i šećernom bolesti tipa 2 u sklopu antihipertenzivne terapije (vidjeti dijelove 4.3, 4.4, 4.5 i 5.1).
English: In particular, they appeared less favourable in women and non-white subjects (see section 5.1).
Croatian: Posebice je bio slabije izražen u žena i bolesnika drugih rasa (vidjeti dio 5.1.).
English: Hyperkalaemia* occurred more often in diabetic patients treated with irbesartan than with placebo.
Croatian: hiperkalijemija* se javljala češće u bolesnika sa šećernom bolesti liječenih irbesartanom nego u skupini koja je primala placebo.
English: Terms marked with a star (*) refer to the adverse reactions that were additionally reported in > 2 % of diabetic hypertensive patients with chronic renal insufficiency and overt proteinuria and in excess of placebo.
Croatian: Pojmovi označeni zvjezdicom (*) odnose se na nuspojave koje su dodatno prijavljene u više od 2% dijabetičkih hipertenzivnih bolesnika s kroničnom insuficijencijom bubrega i manifestnom proteinurijom i to s većom učestalosti nego kod placeba.
English: Irbesartan does not inhibit ACE (kininase-II), an enzyme which generates angiotensin-II and also degrades bradykinin into inactive metabolites.
Croatian: Irbesartan ne inhibira ACE (kininazu II), enzim koji generira angiotenzin-II te degradira bradikinin u neaktivne metabolite.
English: What Irbesartan Teva is and what it is used for What you need to know before you take Irbesartan Teva How to take Irbesartan Teva Possible side effects
Croatian: Što je Irbesartan Teva i za što se koristi Što morate znati prije nego počnete uzimati Irbesartan Teva Kako uzimati Irbesartan Teva
English: Irbesartan Teva prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax and the blood pressure to lower.
Croatian: Irbesartan Teva sprječava vezanje angiotenzina II na te receptore, uzrokujući opuštanje krvnih žila i sniženje krvnog tlaka.
English: While similar blood pressure was achieved in all treatment groups, fewer subjects in the irbesartan 300 mg group (5.2 %) than in the placebo (14.9 %) or in the irbesartan 150 mg group (9.7 %) reached the endpoint of overt proteinuria, demonstrating a 70 % relative risk reduction versus placebo (p = 0.0004) for the higher dose.
Croatian: Dok je sličan krvni tlak postignut u svim ispitivanim skupinama, manje bolesnika u skupini koja je primala 300 mg irbesartana (5,2%) dostiglo je ishod manifestne proteinurije u odnosu na skupinu koja je primala placebo (14,9%) ili na skupinu koja je primala 150 mg irbesartana (9,7%), pokazujući smanjenje relativnog rizika za 70% pri primjeni veće doze u odnosu na placebo (p=0,0004).
English: dizziness, orthostatic dizziness*
Croatian: Često: omaglica, ortostatska omaglica*
English: Symptomatic hypotension, especially after the first dose, may occur in patients who are volume and/or sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting.
Croatian: Simptomatska hipotenzija, posebice nakon prve doze, može se pojaviti u bolesnika sa hipovolemijom i/ili hiponatrijemijom zbog snažne diuretske terapije, restrikcijske dijete sa smanjenim unosom soli,
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see also sections 4.3 and 4.4).
Croatian: Dojenčad čije su majke uzimale antagoniste receptora angiotenzina II treba pažljivo pratiti zbog moguće hipotenzije (također vidjeti dijelove 4.3. i 4.4.).
English: hypersensitivity reactions such as angioedema, rash, urticaria, anaphylactic reaction, anaphylactic shock
Croatian: Nepoznato: reakcije preosjetljivosti kao što su angioedem, osip, urtikarija, anafilaktička reakcija,
English: In patients with high blood pressure and type 2 diabetes with kidney disease, dizziness when getting up from lying or sitting position, low blood pressure when getting up from a lying or sitting position, pain in joints or muscles and decreased levels of a protein in the red blood cells (haemoglobin) were also reported.
Croatian: U bolesnika s povišenim krvnim tlakom, šećernom bolesti tipa 2 i bubrežnom bolešću također su prijavljeni omaglica i nizak krvni tlak nakon podizanja iz sjedećeg ili ležećeg položaja, bol u zglobovima i mišićima i smanjene razine proteina u crvenim krvnim stanicama (hemoglobina).
English: In this case your doctor may perform regular blood tests, especially for measuring blood potassium levels in case of poor kidney function.
Croatian: U tom će Vam slučaju Vaš liječnik možda raditi redovite pretrage krvi, posebno određivanje koncentracije kalija u krvi u slučaju oslabljene funkcije bubrega.
English: Teva Santé Tél: +33 155917800
Croatian: Tél: +33 155917800
English: None of these increases were associated with identifiable clinical musculoskeletal events.
Croatian: Niti jedan od tih slučajeva nije povezan s poremećajima mišićno-koštanog sustava koje je bilo moguće utvrditi.
English: At very high doses (≥ 500 mg/kg/day) degenerative changes in the kidney (such as interstitial nephritis, tubular distension, basophilic tubules, increased plasma concentrations of urea and creatinine) were induced by irbesartan in the rat and the macaque and are considered secondary to the hypotensive effects of the medicinal product which led to decreased renal perfusion.
Croatian: Pri vrlo visokim dozama (≥ 500 mg/kg/dan) irbesartan je izazvao degenerativne promjene na bubrezima (poput intersticijskog nefritisa, tubularne distenzije, bazofilnih tubula, povećane koncentracije ureje i kreatinina u plazmi) kod štakora i makaki majmuna, što se smatra sekundarnim učinkom, uz hipotenzivni učinak lijeka koji dovodi do smanjenja perfuzije bubrega.
English: Very common (may affect more than 1 in 10 people): if you suffer from high blood pressure and type 2 diabetes with kidney disease, blood tests may show an increased level of potassium.
Croatian: Popis nuspojava: Vrlo često (mogu se javiti u više od 1 na 10 osoba): ako imate povišen krvni tlak i šećernu bolest tipa 2 te bolest bubrega, krvne pretrage mogu pokazati povišene vrijednosti kalija.
English: Renal impairment and kidney transplantation
Croatian: Oštećena funkcija bubrega i transplantacija bubrega
English: In 1,715 hypertensive patients with type 2 diabetes, proteinuria ≥ 900 mg/day and serum creatinine ranging from 1.0-3.0 mg/dl, the long-term effects (mean 2.6 years) of irbesartan on the progression of renal disease and all-cause mortality were examined.
Croatian: U 1715 hipertenzivnih bolesnika sa šećernom bolesti tipa 2, proteinurijom ≥900 mg/dan i serumskim kreatininom u rasponu od 1,0 do 3,0 mg/dl ispitivan je dugotrajan učinak irbesartana (prosječno 2,6 godina) na progresiju bubrežne bolesti i svih uzroka mortaliteta.
English: How to take Irbesartan Teva
Croatian: Kako uzimati Irbesartan Teva
English: In patients whose vascular tone and renal function depend predominantly on the activity of the reninangiotensin-aldosterone system (e.g. patients with severe congestive heart failure or underlying renal disease, including renal artery stenosis), treatment with angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists that affect this system has been associated with acute hypotension, azotaemia, oliguria, or rarely acute renal failure (see section 4.5).
Croatian: U bolesnika u kojih vaskularni tonus i funkcija bubrega ovise najviše o aktivnosti renin-angiotenzinaldosteronskog sustava (npr. bolesnici s teškim kongestivnim zatajenjem srca ili postojećom bolesti bubrega, uključujući stenozu bubrežne arterije), liječenje inhibitorima angiotenzin konvertirajućeg enzima ili antagonistima receptora angiotenzina II, koji utječu na taj sustav, povezano je s pojavom akutne hipotenzije, azotemije, oligurije i rijetko, akutnim zatajenjem bubrega (vidjeti dio 4.5).
English: Two large randomised, controlled trials (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)) have examined the use of the combination of an ACE-inhibitor with an angiotensin II receptor blocker.
Croatian: ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) i VA NEPHRON-D (eng. The Veterans Affairs Nephropathy in Diabetes)) ispitivala su primjenu kombinacije ACE inhibitora s blokatorom angiotenzin
English: 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 56 film-coated tablets 60 film-coated tablets 80 film-coated tablets 84 film-coated tablets 90 film-coated tablets 98 film-coated tablets 100 film-coated tablets 50 x 1 film-coated tablets 56 x 1 film-coated tablets
Croatian: 7 filmom obloženih tableta 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 56 filmom obloženih tableta 60 filmom obloženih tableta 80 filmom obloženih tableta 84 filmom obloženih tableta 90 filmom obloženih tableta 98 filmom obloženih tableta 100 filmom obloženih tableta
English: Prior treatment with high dose diuretics may result in volume depletion and a risk of hypotension when initiating therapy with irbesartan (see section 4.4).
Croatian: Prethodno liječenje visokim dozama diuretika može dovesti do smanjenja volumena i rizika od pojave hipotenzije prilikom uvođenja terapije irbesartanom (vidjeti dio
English: Irbesartan Teva is used in adult patients to treat high blood pressure (essential hypertension) to protect the kidney in patients with high blood pressure, type 2 diabetes and laboratory evidence of impaired kidney function.
Croatian: Irbesartan Teva primjenjuje se u odraslih bolesnika za liječenje visokog krvnog tlaka (esencijalne hipertenzije) zaštitu bubrega u bolesnika sa šećernom bolesti tipa 2 koji imaju povišeni krvni tlak i laboratorijski dokazanu oslabljenu bubrežnu funkciju.
English: Regression to normoalbuminuria (< 30 mg/day) was more frequent in the irbesartan 300 mg group (34 %) than in the placebo group (21 %).
Croatian: 30 mg/dan) bila je češća u skupini koja je primala irbesartan 300 mg (34%) nego u skupini koja je primala placebo (21%).
English: As with other medicinal products that affect the renin-angiotensin-aldosterone system, hyperkalaemia may occur during the treatment with irbesartan, especially in the presence of renal impairment, overt proteinuria due to diabetic renal disease, and/or heart failure.
Croatian: Kao i kod ostalih lijekova koji djeluju na renin-angiotenzin-aldosteronski sustav, tijekom liječenja irbesartanom može se pojaviti hiperkalijemija, posebice ako je prisutna i oštećena bubrežna funkcija, izražena proteinurija zbog dijabetičke bubrežne bolesti i/ili zatajenje srca.
English: As observed for angiotensin converting enzyme inhibitors, irbesartan and the other angiotensin antagonists are apparently less effective in lowering blood pressure in black people than in non-blacks, possibly because of higher prevalence of low-renin states in the black hypertensive population (see section 5.1).
Croatian: Kao što je zapaženo kod inhibitora angiotenzin konvertirajućeg enzima, irbesartan i ostali antagonisti angiotenzina očigledno su manje učinkoviti u snižavanju krvnog tlaka u bolesnika crne rase nego u drugih rasa, vjerojatno zbog veće prevalencije stanja niskog renina u populaciji hipertoničara crne rase
English: • Tablet core: povidone, pregelatinized starch (maize), poloxamer 188, microcrystalline cellulose, croscarmellose sodium, colloidal hydrated silica and magnesium stearate.
Croatian: • Jezgra tablete: povidon, prethodno geliran kukuruzni škrob, poloksamer 188, mikrokristalična celuloza, umrežena karmelozanatrij, koloidni hidratizirani silicijev dioksid i magnezijev stearat.
English: What you need to know before you take Irbesartan Teva Do not take Irbesartan Teva
Croatian: Što morate znati prije nego počnete uzimati Irbesartan Teva Kako uzimati Irbesartan Teva
English: and 5.1).
Croatian: 4.4, 4.5 i 5.1).
English: For therapeutic doses of irbesartan in humans, the hyperplasia/hypertrophy of the renal juxtaglomerular cells does not appear to have any relevance.
Croatian: Nije izgledno da je, pri terapijskim dozama irbesartana u ljudi, hiperplazija/hipertrofija bubrežnih jukstaglomerularnih stanica od bilo kakve važnosti.
English: Not known (frequency cannot be estimated from the available data): feeling of spinning, headache, taste disturbance, ringing in the ears, muscle cramps, pain in joints and muscles, reduced number of platelets, abnormal liver function, increased blood potassium levels, impaired kidney function, inflammation of small blood vessels mainly affecting the skin (a condition known as leukocytoclastic vasculitis) and severe allergic reactions (anaphylactic shock).
Croatian: Nepoznato (učestalost se ne može procijeniti iz dostupnih podataka): vrtoglavica, glavobolja, promjene osjeta okusa, zvonjava u ušima, grčevi u mišićima, bol u zglobovima i mišićima, smanjen broj krvnih pločica, poremećaj funkcije jetre, povišena razina kalija u krvi, oslabljena funkcija bubrega, upala malih krvnih žila koja uglavnom zahvaća kožu (stanje poznato kao leukocitoklastični vaskulitis) i teške alergijske reakcije (anafilaktički šok).
English: Swensweg 5, Postbus 552 2003 RN Haarlem The Netherlands
Croatian: Swensweg 5, Postbus 552
English: In hypertensive type 2 diabetic patients, therapy should be initiated at 150 mg irbesartan once daily and titrated up to 300 mg once daily as the preferred maintenance dose for treatment of renal disease.
Croatian: U hipertenzivnih bolesnika sa šećernom bolesti tipa 2 liječenje treba započeti sa 150 mg irbesartana jedanput na dan i dozu titrirati do 300 mg jedanput na dan, što je doza održavanja koja se preporučuje za liječenje bubrežne bolesti.
English: Because no information is available regarding the use of irbersartan during breast-feeding, irbesartan is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
Croatian: Budući da nema dostupnih podataka o upotrebi irbesartana tijekom dojenja, ne preporučuje se njegova primjena tijekom dojenja i prednost treba dati drugoj terapiji s boljim profilom sigurnosti primjene,
English: There is no clinical experience in patients with severe hepatic impairment.
Croatian: Nema kliničkih iskustava s bolesnicima s teškim oštećenjem funkcije jetre.
English: Pack sizes of 7, 14, 28, 30, 56, 60, 80, 84, 90, 98, 100 film-coated tablets in non-perforated blisters.
Croatian: Pakiranja sa 7, 14, 28, 30, 56, 60, 80, 84, 90, 98 i 100 filmom obloženih tableta u neperforiranim blisterima.
English: Reduction of blood pressure with 0.5 mg/kg (low), 1.5 mg/kg (medium) and 4.5 mg/kg (high) target titrated doses of irbesartan was evaluated in 318 hypertensive or at risk (diabetic, family history of hypertension) children and adolescents aged 6 to 16 years over a three week period.
Croatian: mg/kg (niska doza), 1,5 mg/kg (srednja doza) i 4,5 mg/kg (visoka doza) irbesartana u 318 djece i adolescenata s hipertenzijom ili s rizikom od hipertenzije (šećerna bolest, hipertenzija u povijesti bolesti obitelji) u dobi od 6 do 16 godina.
English: Irbesartan Teva is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Croatian: Irbesartan Teva ne preporučuje se u ranoj trudnoći te se ne smije uzimati nakon trećeg mjeseca trudnoće jer može ozbiljno naškoditi Vašem djetetu uzimate li ga u tom razdoblju.
English: In diabetic hypertensive patients with microalbuminuria and normal renal function, hyperkalaemia (≥ 5.5 mEq/L) occurred in 29.4 % of the patients in the irbesartan 300 mg group and 22 % of the patients in the placebo group.
Croatian: U bolesnika sa šećernom bolesti i hipertenzijom, mikroalbuminurijom i normalnom bubrežnom funkcijom, hiperkalijemija (≥ 5,5 mEq/L) se razvila kod 29,4% bolesnika koji su primali 300 mg irbesartana i kod 22% bolesnika u placebo skupini.
English: Adjusted mean change of trough seated diastolic blood pressure (SeDBP) was as follows: 3.8 mm Hg (low dose), 3.2 mm Hg (medium dose), 5.6 mm Hg (high dose).
Croatian: Prilagođena srednja vrijednost promjene dijastoličkog krvnog tlaka u sjedećem položaju u „najnižoj točki djelovanja“ (engl. seated diastolic blood pressure, SeDBP) bila je sljedeća: 3,8 mmHg (niska doza), 3,2 mmHg (srednja doza) i 5,6 mmHg (visoka doza).
English: How to store Irbesartan Teva
Croatian: Kako čuvati Irbesartan Teva
English: Potassium supplements and potassium-sparing diuretics Based on experience with the use of other medicinal products that affect the renin-angiotensin system, concomitant use of potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium or other medicinal products that may increase serum potassium levels (e.g. heparin) may lead to increases in serum potassium and is, therefore, not recommended (see section 4.4).
Croatian: Na temelju iskustva s ostalim lijekovima koji utječu na renin-angiotenzinski sustav, istodobno uzimanje diuretika koji štede kalij, nadomjestaka kalija, nadomjestaka soli koji sadrže kalij ili ostalih lijekova koji mogu povećati serumsku razinu kalija (npr. heparin) može izazvati porast serumskog kalija te se, stoga, ne preporučuje (vidjeti dio 4.4.).
English: Sixty per cent (60 %) of patients in the placebo group reached this target blood pressure whereas this figure was 76 % and 78 % in the irbesartan and amlodipine groups respectively.
Croatian: skupini koja je primala placebo 60% bolesnika postiglo je ciljni krvni tlak dok je ta vrijednost bila 76% u skupini koja je primala irbesartan, odnosno 78% u skupini koja je primala amlodipin.
English: significant increases in plasma creatine kinase were commonly observed (1.7 %) in irbesartan treated subjects.
Croatian: zabilježen je značajan porast kreatin kinaze u plazmi u 1,7% bolesnika koji su uzimali irbesartan.
English: In this case your doctor may perform regular blood tests, especially for measuring blood potassium levels in case of poor kidney function if you are going to have an operation (surgery) or be given anaesthetics if you are taking any of the following medicines used to treat high blood pressure: - an ACE-inhibitor (for example enalapril, lisinopril, ramipril), in particular if you have diabetes-related kidney problems - aliskiren
Croatian: U tom će Vam slučaju Vaš liječnik možda raditi redovite pretrage krvi, posebno određivanje koncentracije kalija u krvi u slučaju oslabljene funkcije bubrega ako trebate ići na operaciju (kirurški zahvat) ili trebate primiti anestetike ako uzimate bilo koji od lijekova navedenih u nastavku, koji se koriste za liječenje visokog krvnog tlaka: - blokator angiotenzin II receptora (ARB) (nazivaju se i sartanima - primjerice valsartan, telmisartan, irbesartan), osobito ako imate bubrežne tegobe povezane sa šećernom bolešću