FrancophonIA/ELRC3.0 huggingface dataset:
English: Effects on unbound exposure could be expected (has not been studied) and therefore caution is advised in patients with moderate hepatic impairment.
Slovenian: Pri okvari jeter lahko pričakujemo učinke zaradi izpostavljenosti nevezanemu zdravilu (ki pa še niso preučeni) in zato svetujemo previdnost pri bolnikih z zmerno okvaro jeter.
English: Study was conducted with tenofovir disoproxil fumarate 300 mg once daily Note: In drug-drug interaction studies, different formulations and/or doses of etravirine were used which led to similar exposures and, therefore, interactions relevant for one formulation are relevant for the other.
Slovenian: V študiji so uporabljali 300 mg tenofovirdizoproksilat fumarata enkrat na dan. Opomba: v študijah medsebojnih delovanj med zdravili so uporabljali različne oblike in/ali odmerke etravirina, s čimer so dosegli podobne stopnje izpostavljenosti, zato veljajo medsebojna delovanja, ki se nanašajo na eno obliko, hkrati tudi za drugo.
English: The recommended dose of etravirine for adults is 200 mg (one 200 mg tablet or two 100 mg tablets) taken orally twice daily following a meal (see section 5.2).
Slovenian: Pri odraslih je priporočeni odmerek etravirina 200 mg (ena 200 mg tableta ali dve 100 mg tableti) peroralno dvakrat na dan po jedi (glejte poglavje 5.2).
English: Reused/not used ENF
Slovenian: Ponovno uporabljeni oz. neuporabljeni ENF
English: Population pharmacokinetic analysis in HIV infected patients showed that etravirine pharmacokinetics are not considerably different in the age range (18 to 77 years) evaluated, with 6 subjects aged 65 years or older (see sections 4.2 and 4.4).
Slovenian: Analiza populacijske farmakokinetike etravirina pri bolnikih, okuženih s HIV, je pokazala, da farmakokinetika etravirina ni bila bistveno drugačna pri proučenem razponu starosti - od 18 do 77 let, pri čemer je bilo 6 preiskovancev starih 65 let ali več (glejte poglavji 4.2 in 4.4).
English: No interaction between pravastatin and etravirine is expected.
Slovenian: Ni pričakovati nobenih medsebojnih delovanj med pravastatinom in etravirinom.
English: ANTIFUNGALS Fluconazole 200 mg once in the morning fluconazole
Slovenian: ANTIMIKOTIKI flukonazol 200 mg enkrat na dan zjutraj flukonazol
English: Unchanged etravirine in faeces is likely to be unabsorbed drug.
Slovenian: Nespremenjen etravirin v blatu je verjetno posledica neabsorbiranega zdravila.
English: < 400 HIV-1 RNA copies/ml n (%)
Slovenian: < 400 HIV-1 RNK kopij/ml n (%)
English: Interactions and dose recommendations with other medicinal products Medicinal products by therapeutic areas
Slovenian: Interakcije z drugimi zdravili in priporočila za odmerjanje Zdravila razvrščena po področjih zdravljenja
English: 0.5 mg single dose digoxin
Slovenian: 0,5 mg enkratni odmerek digoksin
English: Increased unbound exposure could be expected.
Slovenian: Pričakovati je povečano izpostavljenost nevezani učinkovini.
English: Enfuvirtide concentrations not studied and no effect is expected.
Slovenian: Koncentracij enfuvirtida niso preiskovali in medsebojnih delovanj ni pričakovati.
English: Warnings and precautions Talk to your doctor or pharmacist before taking INTELENCE.
Slovenian: Opozorila in previdnostni ukrepi Pred začetkom jemanja zdravila INTELENCE se posvetujte z zdravnikom ali farmacevtom.
English: In women receiving etravirine 200 mg twice daily, higher mean values for Cmax, AUC12h and Cmin were observed during pregnancy compared to postpartum.
Slovenian: Pri ženskah, ki so prejemale 200 mg etravirina dvakrat na dan, so med nosečnostjo opazili večje povprečne vrednosti Cmax, AUC12h in Cmin kot v obdobju po porodu.
English: In vitro experiments with human liver microsomes (HLMs) indicate that etravirine primarily undergoes oxidative metabolism by the hepatic cytochrome CYP450 (CYP3A) system and, to a lesser extent, by the CYP2C family, followed by glucuronidation.
Slovenian: Poskusi in vitro na človeških jetrnih mikrosomih (human liver microsomes - HLM) kažejo, da se etravirin presnavlja predvsem oksidativno s sistemom jetrnega citokroma CYP450 (CYP3A) in v manjši meri s skupino izoencimov CYP2C, čemur sledi glukuronidacija.
English: Always take the tablet following a meal.
Slovenian: Tableto vedno zaužijte po jedi.
English: Immunologic parameters
Slovenian: Imunološki parameteri
English: Use in children and adolescents 6 years of age and older and weighing at least 16 kg The doctor will work out the right dose based on the weight of the child.
Slovenian: Uporaba pri otrocih in mladostnikih (starejših od 6 let s telesno maso najmanj 16 kg) Zdravnik bo določil ustrezen odmerek glede na telesno maso otroka.
English: 6 cells/l
Slovenian: 6 celic/l
English: - In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after you start taking medicines for the treatment of your HIV infection.
Slovenian: - Poleg oportunističnih okužb se lahko po začetku jemanja zdravil za zdravljenje okužbe s HIV pojavijo tudi avtoimunske bolezni (stanja, do katerih pride, ko imunski sistem napade zdravo telesno tkivo).
English: - Virologic response was defined as achieving a confirmed undetectable viral load (< 50 HIV-1 RNA copies/ml).
Slovenian: - Virološki odziv je bil opredeljen kot doseganje potrjeno nemerljivega virusnega bremena (< 50 HIV-1 RNK kopij/ml).
English: INTELENCE is used in combination with other anti-HIV medicines to treat adults and children 6 years of age and older who are infected by HIV and who have used other anti-HIV medicines before.
Slovenian: Zdravilo INTELENCE uporabljamo v kombinaciji z drugimi protiretrovirusnimi zdravili za zdravljenje odraslih in otrok (starejših od 6 let), ki so okuženi z virusom HIV in so pred tem že jemali druga protiretrovirusna zdravila.
English: Known and theoretical interactions with selected antiretrovirals and non-antiretroviral medicinal products are listed in table 1.
Slovenian: Tako znane kot teoretično mogoče interakcije z nekaterimi protiretrovirusnimi zdravili in z drugimi zdravili, ki ne delujejo proti retrovirusom, so navedene v preglednici 1.
English: In rats, there was no effect on mating or fertility with etravirine treatment (see section 5.3).
Slovenian: Pri podganah niso opazili vpliva na parjenje ali plodnost med zdravljenjem z etravirinom (glejte poglavje 5.3).
English: If you take more INTELENCE than you should Contact your doctor or pharmacist immediately.
Slovenian: Če ste vzeli večji odmerek zdravila INTELENCE, kot bi smeli Nemudoma se posvetujte z zdravnikom ali farmacevtom.
English: Etravirine is expected to decrease plasma concentrations of cyclosporine, sirolimus and tacrolimus.
Slovenian: Pričakovati je, da etravirin zniža plazemske koncentracije ciklosporina, sirolimusa in takrolimusa.
English: Results of this analysis (week 48 data) by ENF stratum are shown in table 3.
Slovenian: Rezultati analize ENF skupine (po 48 tednih zdravljenja) so prikazani v preglednici 3.
English: Because 14-OH-clarithromycin has reduced activity against Mycobacterium avium complex (MAC), overall activity against this pathogen may be altered; therefore alternatives to clarithromycin should be considered for the treatment of MAC.
Slovenian: Ker ima 14-hidroksi-klaritromicin zmanjšano delovanje proti kompleksu Mycobacterium avium (MAC), je lahko njegova celotna aktivnost proti temu mikroorganizmu spremenjena.
English: Significantly fewer patients in the etravirine arm reached a clinical endpoint (AIDS-defining illness and/or death) as compared to the placebo arm (p = 0.0408).
Slovenian: V skupini, ki je prejemala etravirin, je statistično značilno manjše število bolnikov doseglo opazovan dogodek (ki je bil določen kot razvoj AIDSa in/ali smrt), kot v skupini, ki je prejemala placebo (p = 0,0408).
English: Driving and using machines Do not drive or operate machines if you feel sleepy or dizzy after taking your medicines.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Ne vozite avtomobila in ne upravljajte z orodji ali stroji, če ste po jemanju zdravil zaspani ali omotični.
English: Based on historical data, a decrease in etravirine exposure may be expected whereas an increase in rifabutin exposure and especially in 25-O-desacetyl-rifabutin may be expected.
Slovenian: Skladno s starejšimi podatki, lahko pričakujemo zmanjšanje izpostavljenosti etravirinu ter povečanje izpostavljenosti rifabutinu in še bolj 25-O-deacetil-rifabutinu.
English: Etravirine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site.
Slovenian: Etravirin se veže naravnost na reverzno transkriptazo (RT) in zavira od RNK in od DNK odvisno aktivnost DNK polimeraze tako, da povzroči motnje na katalitičnem mestu encima.
English: Rare side effects (may affect up to 1 in 1,000 people) - stroke; - severe skin rash with blisters or peeling skin, particularly around the mouth or eyes; this may occur in children and adolescents more frequently than in adults.
Slovenian: Redki neželeni učinki (pojavijo se pri največ 1 od 1.000 bolnikov) - možganska kap - hud kožni izpuščaj z mehurji ali luščenjem kože, zlasti okrog ust ali oči; pri otrocih in mladostnikih prihaja do tega pogosteje kot pri odraslih
English: INTELENCE tablets should be stored in the original bottle and keep the bottle tightly closed in order to protect from moisture.
Slovenian: Zdravilo INTELENCE tablete shranjujte v originalni plastenki, plastenka pa mora biti tesno zaprta za zagotovitev zaščite pred vlago.
English: If you have stopped treatment due to a hypersensitivity reaction, you should not restart therapy with INTELENCE.
Slovenian: Če ste zdravljenje prekinili zaradi preobčutljivostne reakcije, zdravljenja z zdravilom INTELENCE ne smete ponovno začeti.
English: Disopyramide Flecainide Lidocaine (systemic) Mexiletine Propafenone Quinidine
Slovenian: amiodaron bepridil dizopiramid flekainid lidokain (sistemski) meksiletin propafenon kinidin
English: In healthy subjects, the absorption of etravirine is not affected by co-administration of oral ranitidine or omeprazole, medicinal products that are known to increase gastric pH.
Slovenian: Pri zdravih preiskovancih na absorpcijo etravirina ne vpliva sočasna uporaba peroralnega ranitidina ali omeprazola, torej zdravil, za katera je znano, da povečujejo želodčni pH.
English: Since etravirine is highly protein bound, dialysis is unlikely to result in significant removal of the active substance.
Slovenian: Ker se etravirin v veliki meri veže na beljakovine, je malo verjetno, da se bo z dializo odstranila bistvena količina učinkovine.
English: INTELENCE and darunavir/ritonavir can be used without dose adjustments (see also section 5.1).
Slovenian: Zdravilo INTELENCE in kombinacija darunavir/ritonavir se lahko uporabljajo brez prilagajanja odmerkov (glejte poglavje 5.1).
English: INTELENCE has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo INTELENCE ima blag vpliv na sposobnost vožnje in upravljanja strojev.
English: At week 12, virologic response was greater in the control-PI arm (-2.2 log10 copies/ml from baseline; n = 53) compared to the etravirine arm (-1.4 log10 copies/ml from baseline; n = 40).
Slovenian: V 12. tednu je bil virološki odziv večji v kontrolni skupini, ki je prejemala PI (-2,2 log10 kopij/ml glede na začetno vrednost; n = 53) v primerjavi s skupino, ki je prejemala etravirin (-1,4 log10 kopij/ml glede na začetno vrednost; n = 40).
English: These adverse reactions were observed in other clinical trials than DUET-1 and DUET-2.
Slovenian: Navedene neželene učinke o opažali v drugih kliničnih preskušanjih (ne v študijah DUET-1 in DUET-2).
English: Itraconazole and ketoconazole are potent inhibitors as well as substrates of CYP3A4.
Slovenian: Itrakonazol in ketokonazol sta močna zaviralca in tudi substrata za CYP3A4.
English: The breakpoints for reduced efficacy with etravirine (> 2 etravirine-associated mutations at baseline, see clinical results section) applies when etravirine is given in combination with a boosted protease inhibitor.
Slovenian: Mejne vrednosti zmanjšane učinkovitosti etravirina (> 2 z etravirinom-povezane mutacije na začetku zdravljenja, glejte odstavek o kliničnih izkušnjah) se nanašajo na dajanje etravirina v kombinaciji z okrepljenimi zaviralci proteaze.
English: Patients should be instructed to swallow the tablet(s) whole with a liquid such as water.
Slovenian: Bolnike je treba poučiti naj tableto (tablete) pogoltnejo celo (cele) s kozarcem tekočine (na primer vode).
English: Etravirine is a weak inducer of CYP3A4.
Slovenian: Etravirin je šibek induktor izoencima CYP3A4.
English: Therefore, the pharmacokinetic parameter estimates shown in the table account for reductions in the pharmacokinetic parameters of etravirine due to co-administration of etravirine with darunavir/ritonavir.
Slovenian: Zato ocene farmakokinetičnih parametrov v preglednici vključujejo zmanjšanja farmakokinetičnih parametrov etravirina zaradi sočasne uporabe z darunavir/ritonavirjem.
English: The incidence of rash was higher in women compared to men in the etravirine arm in the DUET trials (rash ≥ grade 2 was reported in 9/60 [15.0%] women versus 51/539 [9.5%] men; discontinuations due to rash were reported in 3/60 [5.0%] women versus 10/539 [1.9%] men) (see section 4.4).
Slovenian: V študijah DUET je bila v kraku z etravirinom incidenca izpuščaja pri ženskah večja kot pri moških (o izpuščaju ≥ 2. stopnje so poročali pri 9/60 [15,0%] žensk v primerjavi z 51/539 [9,5%] moških; o prekinitvi zdravljenja zaradi izpuščaja so poročali pri 3/60 [5,0%] žensk v primerjavi z 10/539 [1,9%] moških) (glejte poglavje 4.4).
English: Clarithromycin exposure was decreased by etravirine; however, concentrations of the active metabolite, 14-OH-clarithromycin, were increased.
Slovenian: Etravirin je zmanjšal izpostavljenost klaritromicinu, medtem ko so bile koncentracije njegovega aktivnega presnovka 14-hidroksi-klaritromicina zvišane.
English: In the Phase III studies, the rates of discontinuation due to any adverse reaction were 7.2% in patients receiving etravirine.
Slovenian: V študijah faze III je bila pri bolnikih, ki so prejemali etravirin, pogostnost ukinitve zdravila zaradi katerega koli neželenega učinka 7,2%.
English: INTELENCE, in combination with a boosted protease inhibitor and other antiretroviral medicinal products, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients and in antiretroviral treatment-experienced paediatric patients from 6 years of age (see sections 4.4, 4.5 and 5.1).
Slovenian: Zdravilo INTELENCE je v kombinaciji z okrepljenim zaviralcem proteaze in drugimi protiretrovirusnimi zdravili indicirano za zdravljenje okužbe s humanim virusom imunske pomanjkljivosti tipa 1 (HIV-1) pri odraslih bolnikih, ki so se že zdravili s protiretrovirusnimi zdravili in pediatričnih bolnikih, starejših od 6 let, ki so se že zdravili s protiretrovirusnimi zdravili (glejte poglavja 4.4, 4.5 in 5.1).
English: SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS) Paroxetine
Slovenian: SELEKTIVNI ZAVIRALCI PONOVNEGA PRIVZEMA SEROTONINA (SSRI) paroksetin
English: It is not recommended to combine etravirine with tipranavir/ritonavir, due to a marked pharmacokinetic interaction (76% decrease of etravirine AUC) that could significantly impair the virologic response to etravirine.
Slovenian: Med etravirinom in kombinacijo tipranavir/ritonavir obstaja pomembna farmakokinetična interakcija (76% zmanjšanje AUC etravirina), ki lahko pomembno vpliva na virološki odziv na etravirin.
English: Do not remove the desiccant pouches.
Slovenian: Ne odstranjujte vrečk s sušilnim sredstvom.
English: No changes in methadone dosage were required based on clinical status during or after the period of INTELENCE co-administration.
Slovenian: Glede na klinično stanje bolnikov ni bila potrebna sprememba odmerka metadona med ali po obdobju sočasne uporabe z zdravilom INTELENCE.
English: Note: The median protein binding adjusted EC50 for MT4 cells infected with HIV-1/IIIB in vitro = 4 ng/ml.
Slovenian: Opomba: mediana vrednost EC50 (prirejena za vezavo proteinov) za s HIV-1/IIIB okužene MT4 celice in vitro = 4 ng/ml.
English: The recommended dose of INTELENCE is 200 mg twice a day.
Slovenian: Priporočeni odmerek zdravila INTELENCE je 200 mg dvakrat na dan.
English: Etravirine is a weak inhibitor of CYP2C9 and CYP2C19.
Slovenian: Etravirin je šibek zaviralec izoencimov CYP2C9 in CYP2C19.
English: The clinical data are limited and an increased risk of cutaneous reactions in patients with a history of NNRTI-associated cutaneous reaction cannot be excluded (see section 4.4).
Slovenian: Klinični podatki so omejeni in povečanega tveganja za pojav kožnih reakcij pri bolnikih z anamnezo kožne reakcije zaradi uporabe NNRTI, ni mogoče izključiti (glejte poglavje 4.4).
English: The most frequent side effects of INTELENCE are rash, diarrhoea, nausea, and headache (see section ‘4.
Slovenian: Najpogostejši neželeni učinki zdravila INTELENCE so izpuščaj, driska, slabost in glavobol (glejte poglavje ‘4.
English: Etravirine efficacy in relation to NNRTI resistance at baseline has mainly been analysed with etravirine given in combination with darunavir/ritonavir (DUET-1 and DUET-2).
Slovenian: Učinkovitost etravirina glede na razvoj odpornosti za NNRTI na začetku zdravljenja so preučevali v glavnem z dajanjem etravirina skupaj s kombinacijo darunavir/ritonavir (DUET-1 in DUET-2).
English: In a study comparing 8 patients with mild (Child-Pugh Class A) hepatic impairment to 8 matched controls and 8 patients with moderate (Child-Pugh Class B) hepatic impairment to 8 matched controls, the multiple dose pharmacokinetic disposition of etravirine was not altered in patients with mild to moderate hepatic impairment.
Slovenian: V študiji, v kateri so primerjali 8 bolnikov z blago okvaro jeter (razred A po klasifikaciji Child-Pugh) z 8 ustreznimi kontrolnimi preiskovanci ter 8 bolnikov z zmerno okvaro jeter (razred B po klasifikaciji Child-Pugh) z 8 ustreznimi kontrolnimi preiskovanci, so ugotovili, da farmakokinetika porazdelitve večkratnih odmerkov etravirina pri bolnikih z blago do zmerno okvaro jeter ni bila spremenjena.
English: Raltegravir 400 mg twice daily raltegravir
Slovenian: raltegravir 400 mg dvakrat na dan raltegravir
English: Patients with coexisting conditions
Slovenian: Bolniki z drugimi sočasnimi boleznimi
English: The pharmacokinetics of etravirine in paediatric patients less than 6 years of age are under investigation.
Slovenian: Farmakokinetiko etravirina pri pediatričnih bolnikih, mlajših od 6 let še proučujejo.
English: Table 3: DUET-1 and DUET-2 pooled 48-week data Etravirine + BR N = 599
Slovenian: Preglednica 3: Združeni podatki iz preskušanj DUET-1 in DUET-2 po 48-tednih etravirin + BR N = 599
English: INTELENCE is expected to decrease plasma concentrations of these antiarrhythmics.
Slovenian: Pričakovati je, da zdravilo INTELENCE zniža plazemske koncentracije teh antiaritmikov.
English: INTELENCE should optimally be combined with other antiretrovirals that exhibit activity against the patient's virus (see section 5.1).
Slovenian: Optimalno je, da uporabo zdravila INTELENCE kombinirate z drugimi protiretrovirusnimi zdravili, ki učinkujejo proti bolnikovemu virusu (glejte poglavje 5.1).
English: Adverse reactions such as somnolence and vertigo have been reported in etravirine-treated patients and should be considered when assessing a patient's ability to drive or operate machinery (see section 4.8).
Slovenian: Pri bolnikih, ki so prejemali etravirin, so poročali o neželenih učinkih, kot sta somnolenca in vrtoglavica, kar je treba upoštevati pri oceni bolnikove sposobnosti za vožnjo in upravljanje strojev (glejte poglavje 4.8).
English: In vitro and in vivo studies with etravirine revealed no evidence of a mutagenic potential.
Slovenian: Študije z etravirinom in vitro ter in vivo niso pokazale nikakršnih znakov ali dokazov za mutagenost.
English: The differences were less pronounced for unbound etravirine exposure.
Slovenian: Spremembe so bile manjše pri izpostavljenosti nevezanemu etravirinu.
English: Effects on drug levels Least Squares Mean Ratio (90% CI; 1.00 = No effect)
Slovenian: 90% CI; 1,00 = ni učinka
English: The week 48 results from the pooled analysis of DUET-1 and DUET-2 demonstrated that the etravirine arm was superior to the placebo arm irrespective of whether ENF was used de novo (p = 0.0199) or not (p < 0.0001).
Slovenian: Analiza rezultatov združenih podatkov po 48 tednih trajanja študij DUET-1 in DUET-2 je pokazala da je bilo zdravljenje v kraku z etravirinom uspešnejše v primerjavi s placebom, ne glede na to ali so z ENF zdravili bolnike, ki še niso bili zdravljeni (de novo) (p = 0,0199) ali tiste, ki so že bili zdravljeni (p < 0,0001).
English: There is no specific antidote for overdose with etravirine.
Slovenian: Za preveliko odmerjanje etravirina ni specifičnega antidota.
English: It is not recommended to combine INTELENCE with any of the following medicines: - tipranavir/ritonavir, efavirenz, nevirapine, rilpivirine, indinavir, nelfinavir, atazanavir/cobicistat,
Slovenian: Odsvetujemo uporabo zdravila INTELENCE skupaj z naslednjimi zdravili: - tipranavir/ritonavir, efavirenz, nevirapin, rilpivirin, indinavir, nelfinavir, atazanavir/kobicistat,
English: There are no data with regard to symptomatic overdose with etravirine, but it is possible that the most frequent adverse reactions of etravirine, i.e. rash, diarrhoea, nausea, and headache would be the most common symptoms noted.
Slovenian: Ni podatkov o simptomih prevelikega odmerjanja etravirina; najverjetneje bi se najpogostejši neželeni učinki etravirina (izpuščaj, driska, navzea in glavobol) pojavili tudi kot najpogostejši simptomi prevelikega odmerjanja.
English: 800 mg 3 times daily + etravirine 200 mg every 12 hours boceprevir
Slovenian: 800 mg boceprevirja trikrat na dan + 200 mg etravirina na 12 ur boceprevir
English: If you notice any of these symptoms please inform your doctor.
Slovenian: Če opazite katerega od teh znakov, obvestite zdravnika.
English: Store in the original bottle and keep the bottle tightly closed in order to protect from moisture.
Slovenian: Shranjujte v originalni plastenki in plastenko shranjujte tesno zaprto za zagotovitev zaščite pred vlago.
English: In HIV infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Pri bolnikih, okuženih s HIV, ki imajo hudo imunsko pomanjkljivost v času uvedbe kombinirane protiretrovirusne terapije (CART- combination antiretroviral therapy), se lahko pojavi vnetna reakcija na asimptomatske ali prikrite oportunistične okužbe.
English: Do not use this medicine after the expiry date which is stated on the carton and on the bottle after EXP.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in plastenki poleg oznake EXP. Datum izteka roka uporabnosti se nanaša na zadnji dan navedenega meseca.
English: Rarely, during INTELENCE treatment, you can experience severe skin rash with blisters or peeling skin, particularly around the mouth or eyes or hypersensitivity reaction (allergic reaction including rash and fever but also swelling of the face, tongue or throat, difficulty in breathing or swallowing) which could be potentially life-threatening.
Slovenian: Med zdravljenjem z zdravilom INTELENCE se redko lahko pojavi hud kožni izpuščaj z mehurji ali luščenjem kože, zlasti okrog ust in oči, ali preobčutljivostna reakcija (alergijska reakcija, vključno z izpuščajem in zvišano telesno temperaturo in tudi z otekanjem obraza, jezika ali žrela, težavami z dihanjem ali požiranjem), ki je lahko življenjsko nevarna.
English: Median CD4 cell count
Slovenian: Mediana vrednost števila celic CD4