FrancophonIA/ELRC3.0 huggingface dataset:
English: • an enlargement and weakening of a blood vessel wall or a tear in a blood vessel wall (aneurysms and artery dissections),
Croatian: ● proširenje i slabljenje stijenke krvne žile ili rascjep stijenke krvne žile (aneurizme i disekcije arterije),
English: You may be advised to have a dental check-up before you start treatment with Avastin.
Croatian: Možda će Vam biti preporučeno da prije početka liječenja lijekom Avastin obavite stomatološki pregled.
English: Overall Response Rate
Croatian: Stopa ukupnog odgovora
English: Chemotherapy was chosen at the investigator's discretion prior to randomisation in a 2:1 ratio to receive either chemotherapy plus Avastin or chemotherapy plus placebo.
Croatian: Izbor kemoterapije bio je prepušten ispitivaču prije randomizacije u omjeru 2:1 za kemoterapiju plus Avastin u odnosu na kemoterapiju plus placebo.
English: The safety of reinitiating Avastin therapy in patients previously experiencing PRES is not known.
Croatian: Nije poznata sigurnost ponovnog uvođenja lijeka Avastin u bolesnika koji su prethodno imali PRES.
English: Overall response rate Rate (%)
Croatian: Ukupna stopa odgovora Stopa (%)
English: Overall survival - Primary analysis1 Hazard Ratio (95% CI)
Croatian: Ukupno preživljenje - Primarna analiza1 Omjer hazarda (95% CI)
English: Cap + Pl (n=206)
Croatian: Kap + pl (n= 206)
English: Fistulae have also been reported in post-marketing experience.
Croatian: Fistule su prijavljene i u razdoblju nakon stavljanja lijeka u promet.
English: Permanently discontinue Avastin in patients with tracheoesophageal (TE) fistula or any Grade 4 fistula [US National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE v.3)].
Croatian: Terapiju lijekom Avastin treba trajno obustaviti u bolesnika s traheoezofagealnom fistulom ili bilo kojom fistulom stupnja 4 [prema Općim terminološkim kriterijima za štetne događaje Nacionalnog instituta za rak SAD-a (NCI-CTCAE v.3)].
English: CT (n=144)
Croatian: KT (n=144)
English: Avastin will be administered together with a chemotherapy regimen containing platinum.
Croatian: Avastin će se davati zajedno s kemoterapijom koja sadrži platinu.
English: Dose reduction for adverse reactions is not recommended.
Croatian: Ne preporučuje se smanjivati dozu zbog nuspojava.
English: In patients developing PRES, early recognition of symptoms with prompt treatment of specific symptoms including control of hypertension (if associated with severe uncontrolled hypertension) is recommended in addition to discontinuation of bevacizumab therapy.
Croatian: U bolesnika u kojih se razvije PRES, uz obustavu bevacizumaba preporučuje se rano prepoznavanje simptoma i brzo liječenje specifičnih simptoma, uključujući kontrolu hipertenzije (ako je sindrom povezan s teškom neliječenom hipertenzijom).
English: In study BO25041 of Avastin added to postoperative radiation therapy (RT) with concomitant and adjuvant temozolomide in paediatric patients with newly diagnosed supratentorial, infratentorial, cerebellar, or peduncular high-grade glioma, the safety profile was comparable with that observed in other tumour types in adults treated with Avastin.
Croatian: U ispitivanju BO25041, u kojem se ocjenjivao Avastin kao dodatak poslijeoperacijskoj radioterapiji (RT) uz istodobnu i adjuvantnu primjenu temozolomida u pedijatrijskih bolesnika s novodijagnosticiranim supratentorijalnim, infratentorijalnim, cerebelarnim ili pedunkularnim gliomom visokog stupnja, sigurnosni profil bio je usporediv s onim opaženim kod drugih vrsta tumora u odraslih liječenih lijekom Avastin.
English: Very common (affects more than 1 user in 10) side effects, which were not severe, include:
Croatian: Vrlo česte (javljaju se u više od 1 na 10 korisnika) nuspojave koje nisu teške uključuju:
English: The primary endpoints of the trial were objective response rate and progression-free survival.
Croatian: Primarne mjere ishoda ispitivanja bile su stopa objektivnog odgovora i preživljenje bez progresije bolesti.
English: Erlotinib N = 77#
Croatian: N = 77#
English: Effect of bevacizumab on the pharmacokinetics of other antineoplastic agents No clinically relevant interaction of bevacizumab was observed on the pharmacokinetics of coadministered interferon alpha 2a, erlotinib (and its active metabolite OSI-420), or the chemotherapies irinotecan (and its active metabolite SN38), capecitabine, oxaliplatin (as determined by measurement of free and total platinum), and cisplatin.
Croatian: Nije primijećena klinički značajna interakcija bevacizumaba na farmakokinetiku istodobno primijenjenog interferona alfa-2a, erlotiniba (i njegova aktivnog metabolita OSI-420) ni kemoterapeutika irinotekana (i njegova aktivnog metabolita SN38), kapecitabina, oksaliplatina (što je utvrđeno određivanjem slobodne platine i ukupne platine) i cisplatina.
English: Epithelial ovarian, fallopian tube and primary peritoneal cancer
Croatian: Epitelni karcinom jajnika, karcinom jajovoda i primarni peritonealni karcinom
English: Paclitaxel n=115
Croatian: Paklitaks e l n=115
English: Cases of foetal abnormalities in women treated with bevacizumab alone or in combination with known embryotoxic chemotherapeutics have been observed (see section 4.6 )
Croatian: Primijećeni su slučajevi poremećaja fetusa u žena liječenih bevacizumabom samostalno ili u kombinaciji s poznatim embriotoksičnim kemoterapeuticima (vidjeti dio 4.6)
English: Congestive heart failureb,d, Supraventricular tachycardia
Croatian: Srčani poremećaji kongestivno zatajenje srcab,d supraventrikularna tahikardija
English: ● Avastin can also increase the risk of developing blood clots in your veins (a type of blood vessel).
Croatian: Avastin može povećati i rizik od nastanka krvnih ugrušaka u venama (vrsta krvnih žila).
English: Relative to control arm
Croatian: U odnosu na kontrolnu skupinu
English: The 131 patients in the Avastin + IFN alfa-2a arm who reduced and maintained the IFN alfa-2a dose at 6 or 3 MIU during the trial, exhibited at 6, 12 and 18 months PFS event free rates of 73, 52 and 21% respectively, as compared to 61, 43 and 17% in the total population of patients receiving Avastin + IFN alfa-2a.
Croatian: U 131 bolesnika koji su primali Avastin + IFN alfa-2a i kojima je doza IFN alfa-2a smanjena i održana tijekom ispitivanja na 6 ili 3 milijuna IU, stopa preživljenja bez progresije bolesti iznosila je 73% nakon 6 mjeseci, 52% nakon 12 mjeseci te 21% nakon 18 mjeseci, u usporedbi sa 61%, 43% odnosno 17% u ukupnoj populaciji bolesnika koji su primali Avastin + IFN alfa-2a.
English: Combination with platinum- or taxane-based therapies (see sections 4.4 and 4.8) Increased rates of severe neutropenia, febrile neutropenia, or infection with or without severe neutropenia (including some fatalities) have been observed mainly in patients treated with platinumor taxane-based therapies in the treatment of NSCLC and mBC.
Croatian: Kombinacija s kemoterapijom na bazi platinskog spoja ili taksana (vidjeti dijelove 4.4 i 4.8) Povećane stope teške neutropenije, febrilne neutropenije te infekcije praćene teškom neutropenijom ili bez nje (s nekoliko smrtnih ishoda) opažene su većinom u bolesnika koji su primali kemoterapiju na bazi platinskog spoja ili taksana u liječenju karcinoma pluća nemalih stanica i metastatskog karcinoma dojke.
English: In the post-marketing setting, cases of foetal abnormalities in women treated with bevacizumab alone or in combination with known embryotoxic chemotherapeutics have been observed (see section 4.8).
Croatian: Nakon stavljanja lijeka u promet primijećeni su slučajevi poremećaja fetusa u žena liječenih bevacizumabom samostalno ili u kombinaciji s poznatim embriotoksičnim kemoterapeuticima (vidjeti dio 4.8).
English: In a study of platinum-resistant recurrent ovarian cancer patients, alopecia, mucosal inflammation, peripheral sensory neuropathy, proteinuria and hypertension were also reported and occurred at a rate at least 5% higher in the CT + BV arm for bevacizumab-treated patients ≥ 65 years of age compared with bevacizumab-treated patients aged < 65 years.
Croatian: ispitivanju recidiva karcinoma jajnika rezistentnog na platinu prijavljene su i alopecija, upala sluznice, periferna senzorna neuropatija, proteinurija i hipertenzija, a stopa njihova pojavljivanja u skupini koja je primala kemoterapiju i bevacizumab bila je najmanje 5% veća u bolesnica liječenih bevacizumabom u dobi od ≥ 65 godina nego u bolesnica liječenih bevacizumabom u dobi od ≤ 65 godina.
English: Treatment with Avastin at 15 mg/kg every 3 weeks in combination with chemotherapy (carboplatin and paclitaxel) for 6 and up to 8 cycles, followed by Avastin until disease progression or unacceptable toxicity resulted, when data were derived from eCRF, in a clinically meaningful and statistically significant improvement in OS compared to treatment with carboplatin and paclitaxel alone.
Croatian: Liječenje lijekom Avastin u dozi od 15 mg/kg svaka 3 tjedna u kombinaciji s kemoterapijom (karboplatinom i paklitakselom) tijekom 6, a najviše 8 ciklusa, a zatim lijekom Avastin do progresije bolesti ili do pojave neprihvatljive toksičnosti, dovelo je, kada su prikupljeni podaci iz elektroničkih test lista ispitanica, do klinički važnog i statistički značajnog poboljšanja OS-a u usporedbi s liječenjem samo karboplatinom i paklitakselom.
English: There is no relevant use of bevacizumab in the paediatric population in the indications for treatment of cancers of the colon, rectum, breast, lung, ovarian, fallopian tube, peritoneum, cervix and kidney.
Croatian: Nema relevantne primjene bevacizumaba u pedijatrijskoj populaciji za indikacije liječenja karcinoma kolona, rektuma, dojke, pluća, jajnika, jajovoda, peritoneuma, cerviksa i bubrega.
English: Statistical analyses were performed independently for 1) patients who received capecitabine in combination with Avastin or placebo; 2) patients who received taxane-based or anthracycline-based chemotherapy in combination with Avastin or placebo.
Croatian: Statističke analize napravljene su posebno za: 1) bolesnike koji su primali kapecitabin u kombinaciji s lijekom Avastin odnosno placebom te 2) bolesnike koji su primali kemoterapiju na bazi taksana ili antraciklina u kombinaciji s lijekom Avastin odnosno placebom.
English: When events were noted as both all grade and grade 3-5 adverse drug reactions in clinical trials, the highest frequency observed in patients has been reported.
Croatian: Za događaje koji su zabilježeni kao nuspojave u kliničkim ispitivanjima svih stupnjeva težine i stupnja težine 3-5, prijavljena je najveća učestalost zabilježena u bolesnika.
English: Patients with hepatic impairment: The safety and efficacy have not been studied in patients with hepatic impairment (see section 5.2).
Croatian: Bolesnici s oštećenjem jetrene funkcije: Nisu ispitivane sigurnost primjene i djelotvornost u bolesnika s oštećenjem jetrene funkcije (vidjeti dio 5.2).
English: CT+BV (n=179)
Croatian: KT+BV (n=179)
English: CT+BV (n=142)
Croatian: KT+BV (n=142)
English: • runny nose,
Croatian: ● curenje iz nosa,
English: Median PFS (on treatment)**
Croatian: Sekundarne mjere ishoda Medijan PFS-a (tijekom liječenja)**
English: ● if you undergo surgery.
Croatian: ● u slučaju planirane operacije.
English: Ovarian failure/fertility (see sections 4.4 and 4.6)
Croatian: Zatajenje jajnika/plodnost (vidjeti dijelove 4.4 i 4.6)
English: Eight hundred and thirteen patients were randomised to receive IFL + placebo (Arm 1) or IFL + Avastin (5 mg/kg every 2 weeks, Arm 2).
Croatian: Randomizirano je 813 bolesnika, u skupinu koja je primala IFL + placebo (skupina 1) ili u skupinu koja je primala IFL + Avastin (5 mg/kg svaka 2 tjedna, skupina 2).
English: All treatments were continued until disease progression.
Croatian: Liječenje je u svih bolesnika nastavljeno do progresije bolesti.
English: Patients were randomised to paclitaxel alone (90 mg/m2 IV over 1 hour once weekly for three out of four weeks) or in combination with Avastin (10 mg/kg IV infusion every two weeks).
Croatian: Bolesnici su randomizirani u skupinu koja je primala samo paklitaksel (90 mg/m intravenski u trajanju od jednog sata, jedanput na tjedan tijekom tri od četiri tjedna), ili paklitaksel u kombinaciji s lijekom Avastin (10 mg/kg intravenskom infuzijom svaka dva tjedna).
English: Objective response rate
Croatian: Stopa objektivnog odgovora
English: Clinical safety data suggest that the incidence of minor mucocutaneous haemorrhage (e.g. epistaxis) may be dose-dependent.
Croatian: Klinički podaci o sigurnosti primjene upućuju na to da bi incidencija manjih mukokutanih krvarenja (npr. epistaksa) mogla ovisiti o dozi.
English: • infections of the skin or deeper layers under the skin,
Croatian: ● infekcije kože ili dubljih potkožnih slojeva,
English: After completion of six cycles of carboplatin-paclitaxel chemotherapy or upon premature discontinuation of chemotherapy, patients on the Avastin + carboplatin-paclitaxel arm continued to receive Avastin as a single agent every 3 weeks until disease progression.
Croatian: Nakon završetka šest ciklusa kemoterapije s karboplatinom i paklitakselom ili preuranjenog prekida kemoterapije, bolesnici u skupini koja je primala Avastin + karboplatin i paklitaksel nastavili su primati samo Avastin svaka 3 tjedna do progresije bolesti.
English: LIST OF EXCIPIENTS Trehalose dihydrate, sodium phosphate, polysorbate 20, water for injections.
Croatian: Trehaloza dihidrat, natrijev fosfat, polisorbat 20, voda za injekcije.
English: Patients treated for persistent, recurrent, or metastatic cervical cancer with Avastin are at increased risk of fistulae between the vagina and any part of the GI tract (Gastrointestinal-vaginal fistulae).
Croatian: Bolesnice koje se liječe lijekom Avastin zbog perzistentnog, recidivirajućeg ili metastatskog karcinoma cerviksa izložene su povećanom riziku od nastanka fistula između rodnice i bilo kojeg dijela gastrointestinalnog trakta (gastrointestinalno-vaginalne fistule).
English: • stomach and intestinal disorder,
Croatian: ● poremećaj želuca i crijeva,
English: In clinical trials, the incidence of arterial thromboembolic reactions including cerebrovascular accidents (CVAs), transient ischaemic attacks (TIAs) and myocardial infarctions (MIs) was higher in patients receiving Avastin in combination with chemotherapy compared to those who received chemotherapy alone.
Croatian: U kliničkim je ispitivanjima učestalost arterijskih tromboembolijskih reakcija, uključujući cerebrovaskularne incidente (CVI), tranzitorne ishemijske atake (TIA) te infarkt miokarda (IM), bila viša u bolesnika koji su primali Avastin u kombinaciji s kemoterapijom u usporedbi s onima koji su primali samo kemoterapiju.
English: 2 Patients and percentage of patients with best overall response of confirmed CR or PR; percentage calculated on patients with measurable disease at baseline
Croatian: Bolesnice i postotak bolesnica s najboljim ukupnim odgovorom koji uključuje potvrđeni djelomičan ili potpun odgovor; postotak izračunat na temelju bolesnica s mjerljivom bolešću na početku ispitivanja
English: There was a small difference, of borderline significance, between the time to progression of disease in the 3 mg/kg group and that in the placebo group (hazard ratio, 1.26; p=0.053).
Croatian: Istodobno je utvrđena mala razlika, granične značajnosti, u vremenu do progresije bolesti u skupini koja je primala dozu od 3 mg/kg u odnosu na skupinu na placebu (omjer rizika 1,26; p = 0,053).
English: Efficacy results for study JO25567
Croatian: Tablica 14 Rezultati djelotvornosti za ispitivanje JO25567
English: 5-FU/FA 5-FU/FA + Avastina
Croatian: 5-FU/FA 5-FU/FA + Avastin a
English: The majority of patients (CP: 64.6%; CPB: 68.8%) were in the age category < 65 years.
Croatian: CPB: 68,8%) bila u dobnoj skupini < 65 godina.
English: Patients who have experienced a venous thromboembolic reaction may be at higher risk for a recurrence if they receive Avastin in combination with chemotherapy versus chemotherapy alone.
Croatian: Bolesnici koji su imali vensku tromboembolijsku reakciju mogu biti izloženi većem riziku od njenog ponovnog pojavljivanja ako prime Avastin u kombinaciji s kemoterapijom nego ako prime samo kemoterapiju.
English: METHOD OF ADMINISTRATION For intravenous use after dilution
Croatian: NAČIN PRIMJENE LIJEKA Za intravensku primjenu nakon razrjeđivanja
English: Cap + Avastin (n=409)
Croatian: Kap + Avastin (n= 409)
English: • hole in the gall bladder (symptoms and signs may include abdominal pain, fever, and nausea/vomiting).
Croatian: ● napuknuće žučnog mjehura (simptomi i znakovi mogu uključivati bol u trbuhu, vrućicu te mučninu i povraćanje).
English: As Avastin may adversely impact wound healing, patients who had major surgery within the last 28 days were excluded from participation in phase III clinical trials.
Croatian: Zacjeljivanje rana (vidjeti dio 4.4) Budući da Avastin može nepovoljno utjecati na zacjeljivanje rana, bolesnici koji su bili podvrgnuti opsežnijoj operaciji u prethodnih 28 dana nisu bili uključeni u klinička ispitivanja faze III.
English: For patients in study AVF3694g who received anthracyclines concomitantly with bevacizumab, the incidences of Grade 3 or higher CHF for the respective bevacizumab and control arms were similar to those in the other studies in metastatic breast cancer: 2.9% in the anthracycline + bevacizumab arm and 0% in the anthracycline + placebo arm.
Croatian: U bolesnika iz ispitivanja AVF3694g koji su primali antracikline zajedno s bevacizumabom, incidencija kongestivnog zatajenja srca stupnja 3 ili višeg stupnja bila je i u skupini na bevacizumabu i u kontrolnoj skupini slična incidenciji u drugim ispitivanjima metastatskog karcinoma dojke: 2,9% u skupini koja je primala antraciklin + bevacizumab te 0% u skupini koja je primala antraciklin + placebo.
English: Avastin should be discontinued permanently in patients who experience Grade 3 or 4 bleeding during Avastin therapy (NCI-CTCAE v.3) (see section 4.8).
Croatian: Avastin valja trajno obustaviti u bolesnika u kojih tijekom liječenja ovim lijekom nastupi krvarenje stupnja 3 ili 4 (NCI-CTCAE v.3) (vidjeti dio 4.8).
English: The addition of erlotinib to bevacizumab did not result in an improvement in OS (HR = 1.764; p=0.1789), duration of objective response (6.7 vs 9.1 months) or time to symptom progression (HR = 1.172; p=0.5076).
Croatian: (HR = 1,764; p = 0,1789), trajanje objektivnog odgovora (6,7 naprama 9,1 mjeseci) niti vrijeme do progresije simptoma (HR = 1,172; p = 0,5076).
English: The VEGF protein causes blood vessels to grow within tumours, these blood vessels provide the tumour with nutrients and oxygen.
Croatian: Protein VEGF uzrokuje rast krvnih žila u tumoru, koje opskrbljuju tumor hranjivim tvarima i kisikom.
English: • sores in the mouth and the tube from the mouth to the stomach, which may be painful and cause difficulty swallowing,
Croatian: ● ranice u ustima i jednjaku koje mogu biti bolne i uzrokovati poteškoće pri gutanju,
English: Hypersensitivity to Chinese Hamster Ovary (CHO) cell products or other recombinant human or humanised antibodies.
Croatian: Preosjetljivost na produkte stanica jajnika kineskog hrčka ili druga rekombinantna humana ili humanizirana protutijela.
English: The safety and efficacy of Avastin in the front-line treatment of patients with epithelial ovarian, fallopian tube or primary peritoneal cancer were studied in two phase III trials (GOG-0218 and BO17707) that evaluated the effect of the addition of Avastin to carboplatin and paclitaxel compared to the chemotherapy regimen alone.
Croatian: Sigurnost primjene i djelotvornost lijeka Avastin u prvoj liniji liječenja bolesnica s epitelnim karcinomom jajnika, karcinomom jajovoda ili primarnim peritonealnim karcinomom ispitivane su u dva ispitivanja faze III (GOG-0218 i BO17707), koja su procjenjivala učinak dodavanja lijeka Avastin karboplatinu i paklitakselu u usporedbi s liječenjem samo tim kemoterapijskim protokolom.
English: MAHA is a haemolytic disorder which can present with red cell fragmentation, anaemia, and thrombocytopenia.
Croatian: MAHA je hemolitički poremećaj koji se može manifestirati fragmentacijom eritrocita, anemijom i trombocitopenijom.
English: Serious wound healing complications, including anastomotic complications, with a fatal outcome have been reported.
Croatian: Prijavljene su ozbiljne komplikacije pri zacjeljivanju rana, uključujući i komplikacije vezane uz anastomozu, sa smrtnim ishodom.
English: In some cases underlying intra-abdominal inflammation was present, either from gastric ulcer disease, tumour necrosis, diverticulitis, or chemotherapy-associated colitis.
Croatian: U nekim slučajevima bila je prisutna otprije postojeća intraabdominalna upala, uzrokovana ulkusom želuca, nekrozom tumora, divertikulitisom ili kolitisom povezanim s kemoterapijom.
English: Investigator assessment
Croatian: Procjena ispitivača
English: The clinical benefit of Avastin as measured by PFS was seen in all pre-specified subgroups tested (including disease-free interval, number of metastatic sites, prior receipt of adjuvant chemotherapy and oestrogen receptor (ER) status).
Croatian: Klinička korist lijeka Avastin, određena prema preživljenju bez progresije bolesti, uočena je u svim unaprijed definiranim ispitanim podskupinama (uključujući razdoblje bez bolesti, broj metastatskih sijela, prethodno liječenje adjuvantnom kemoterapijom i status estrogenskih receptora (ER)).
English: There were no objective (partial or complete) radiological responses (MacDonald criteria).
Croatian: radiološkog odgovora (kriterij po MacDonaldu).
English: Use of irinotecan- or oxaliplatin-containing regimen was switched depending on first-line usage of either oxaliplatin or irinotecan.
Croatian: Protokoli koji sadrže irinotekan odnosno oksaliplatin promijenjeni su ovisno o tome je li u prvoj liniji primijenjen oksaliplatin ili irinotekan.
English: p-value 3, 4 Objective response Rate
Croatian: p-vrijednost Objektivna stopa odgovora 5
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati Avastin Lijek čuvajte izvan pogleda i dohvata djece.
English: In these studies, bevacizumab was administered at the following dosing regimens in combination with FOLFOX-4 (5-FU/LV/oxaliplatin), XELOX (capecitabine/oxaliplatin), and fluoropyrimidine/irinotecan and fluoropyrimidine/oxaliplatin:
Croatian: U tim je ispitivanjima bevacizumab primjenjivan u kombinaciji s protokolima FOLFOX-4 (5FU/LV/oksaliplatin) i XELOX (kapecitabin/oksaliplatin) te fluoropirimidin/irinotekan i fluoropirimidin/oksaliplatin u sljedećim režimima doziranja:
English: Ninety seven (97) patients in the IFN alfa-2a arm and 131 patients in the Avastin arm reduced the dose of IFN alfa-2a from 9 MIU to either 6 or 3 MIU three times a week as pre-specified in the protocol.
Croatian: U 97 bolesnika koji su primali IFN alfa-2a i 131 bolesnika koji je primao Avastin doza interferona alfa-2a smanjena je s 9 milijuna IU na 6 ili 3 milijuna IU tri puta tjedno, kako je prethodno utvrđeno u protokolu ispitivanja.
English: The majority of patients included in the study were White (96%), the median age was 57 years in both treatment arms, 25% of patients in each treatment arm were 65 years of age or over, and approximately 50% of patients had an ECOG PS of 1; 7% of patients in each treatment arm had an
Croatian: Većina bolesnica obuhvaćenih ispitivanjem bila je bijele rase (96%), medijan dobi u obje je skupine iznosio 57 godina, a 25% bolesnica u svakoj skupini imalo je 65 ili više godina.
English: When used for patients with breast cancer, it will be administered with a chemotherapy medicinal product called paclitaxel or capecitabine.
Croatian: Kada se koristi za bolesnike s rakom dojke, primjenjuje se uz kemoterapiju lijekovima paklitakselom ili kapecitabinom.
English: Cap + Pl (n=161)
Croatian: Kap + pl (n= 161)
English: 60.0 years in the CP arm and 59.0 years in the CPB arm.
Croatian: Medijan dobi iznosio je 60,0 godina u skupini CP te 59,0 godina u skupini CPB.