FrancophonIA/ELRC3.0 huggingface dataset:
English: Some patients taking combination anti-retroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki se zdravijo s kombiniranim protiretrovirusnim zdravljenjem, se lahko pojavi bolezen kosti, imenovana osteonekroza (odmrtje kostnine zaradi nezadostne prekrvavljenosti kosti).
English: Volume (Dose) of Suspension to be Administered
Slovenian: Količina (odmerek) suspenzije, ki jo (ga) je treba uporabiti
English: However, the effect of raltegravir on darunavir plasma concentrations does not appear to be clinically meaningful.
Slovenian: Vendar pa kaže, da vpliv raltegravirja na plazemske koncentracije darunavirja ni klinično pomemben.
English: No effect on fertility was seen in male and female rats at doses up to 600 mg/kg/day which resulted in 3-fold exposure above the exposure at the recommended human dose.
Slovenian: Vpliva na plodnost pri samcih in samicah podgan pri odmerkih do 600 mg/kg/dan, ki so povzročili 3-krat višjo izpostavljenost kot pri priporočenem odmerku za človeka, niso opazili.
English: The doctor will tell you if and when to stop giving Isentress to your baby.
Slovenian: Zdravnik vam bo povedal, ali morate zdravilo Isentress otroku nehati dajati in kdaj.
English: Note: The chewable tablets are available as 25 mg and 100 mg tablets.
Slovenian: Opomba: Žvečljive tablete so na voljo kot 25 mg in 100 mg tablete.
English: For each of the following clinical adverse reactions there was at least one serious occurrence: genital herpes, anaemia, immune reconstitution syndrome, depression, mental disorder, suicide attempt, gastritis, hepatitis, renal failure, accidental overdose.
Slovenian: Pri vsakem od naslednjih kliničnih neželenih učinkov je bil vsaj en resen: genitalni herpes, anemija, sindrom imunske obnove, depresija, duševne motnje, poskus samomora, gastritis, hepatitis, odpoved ledvic, nenamerno preveliko odmerjanje.
English: Tear or cut open the sachet and add all of the granules to the water in the mixing cup.
Slovenian: Vrečico odprite tako, da jo pretrgate ali odrežete in vsujte vsa zrnca v vodo, ki je v posodici za mešanje.
English: In the first study (n=18), the median cerebrospinal fluid concentration was 5.8 % (range 1 to 53.5 %) of the corresponding plasma concentration.
Slovenian: V prvi študiji (n = 18) je mediana koncentracija v cerebrospinalni tekočini znašala 5,8 % (v intervalu od 1 do 53,5 %) odgovarjajoče koncentracije v plazmi.
English: The most frequently reported serious adverse reactions were immune reconstitution syndrome and rash.
Slovenian: Resna neželena učinka, o katerih so najpogosteje poročali, sta bila sindrom imunske obnove in izpuščaj.
English: Do not wash in the dishwasher.
Slovenian: Ne pomivajte v pomivalnem stroju.
English: Dose proportionality has not been established in patients.
Slovenian: Pri bolnikih sorazmernost z odmerkom niso dokazali.
English: Comparable efficacy and safety results were obtained in the absence or presence of these gastric pH-altering agents.
Slovenian: Rezultati učinkovitosti in varnosti so bili v prisotnosti in odsotnosti teh učinkovin, ki spreminjajo pH v želodcu, primerljivi.
English: Less potent UGT1A1 inhibitors (e.g., indinavir, saquinavir) may also increase plasma levels of raltegravir, but to a lesser extent compared with atazanavir.
Slovenian: Tudi manj močni zaviralci UGT1A1 (npr. indinavir, sakvinavir) lahko povečajo koncentracijo raltegravirja v plazmi, vendar v manjši meri kot atazanavir.
English: methadone AUC ↔ methadon Cmax ↔
Slovenian: metadon AUC ↔ metadon Cmax ↔
English: • stomach inflammation
Slovenian: • vnetje želodca
English: Effect of other medicinal products on the pharmacokinetics of raltegravir
Slovenian: Vpliv drugih zdravil na farmakokinetiko raltegravirja
English: Patients co-infected with hepatitis B and/or hepatitis C virus In clinical trials, there were 79 patients co-infected with hepatitis B, 84 co-infected with hepatitis C, and 8 patients co-infected with hepatitis B and C who were treated with raltegravir in combination with other agents for HIV-1.
Slovenian: Bolniki, sočasno okuženi z virusom hepatitisa B in/ali hepatitisa C V kliničnih preskušanjih je bilo 79 bolnikov sočasno okuženih s hepatitisom B, 84 bolnikov sočasno okuženih s hepatitisom C, in 8 bolnikov sočasno okuženih s hepatitisom B in C; zdravili so se z raltegravirjem v kombinaciji z drugimi zdravili za HIV-1.
English: Other medicines and Isentress
Slovenian: Druga zdravila in zdravilo Isentress
English: There are no data for the use of raltegravir chewable tablets in pregnant women.
Slovenian: Ni podatkov o uporabi raltegravir žvečljivih tablet pri nosečnicah.
English: Hypersensitivity reactions have also been reported and were characterised by rash, constitutional findings, and sometimes, organ dysfunction, including hepatic failure.
Slovenian: Poročali so tudi o preobčutljivostnih reakcijah, za katere so bili značilni izpuščaj, sistemski znaki in včasih moteno delovanje organov, vključno z odpovedjo jeter.
English: Less potent inducers (e.g., efavirenz, nevirapine, etravirine, rifabutin, glucocorticoids, St. John's wort, pioglitazone) may be used with the recommended dose of raltegravir.
Slovenian: Manj močne induktorje (npr. efavirenz, nevirapin, etravirin, rifabutin, glukokortikoide, šentjanževko, pioglitazon) se lahko uporablja skupaj s priporočenim odmerkom raltegravirja.
English: 3 to less than 4 2.5 mL (25 mg) twice daily 4 to less than 6 3 mL (30 mg) twice daily 6 to less than 8 4 mL (40 mg) twice daily 8 to less than 11 6 mL (60 mg) twice daily 11 to less than 14
Slovenian: Število žvečljivih tablet od 3 do manj kot 4 2,5 ml (25 mg) dvakrat na dan od 4 do manj kot 6 3 ml (30 mg) dvakrat na dan od 6 do manj kot 8 4 ml (40 mg) dvakrat na dan od 8 do manj kot 11 6 ml (60 mg) dvakrat na dan od 11 do manj kot 14
English: Rash occurred more commonly in treatment-experienced patients receiving regimens containing raltegravir and darunavir compared to patients receiving raltegravir without darunavir or darunavir without raltegravir (see section 4.8).
Slovenian: Izpuščaj se je pogosteje pojavil pri že zdravljenih bolnikih, ki so prejemali raltegravir in darunavir, kot pri bolnikih, ki so prejemali raltegravir brez darunavirja ali darunavir brez raltegravirja (glejte poglavje 4.8).
English: For patients weighing at least 25 kg but are unable to swallow a tablet, consider the chewable tablet.
Slovenian: Pri bolnikih s telesno maso najmanj 25 kg, ki tablete ne morejo pogoltniti, je treba razmisliti o uporabi žvečljivih tablet.
English: BLUE
Slovenian: MODRA
English: • drug ingestion in quantities greater than recommended
Slovenian: • zaužitje večje količine zdravila, kot je priporočljivo
English: Number with genotype available One patient had a mutation at the 155 position.
Slovenian: 48. teden brez odziva ponovitev število z določenim genotipom En bolnik je imel mutacijo na mestu 155.
English: IMPAACT P1110 is a Phase I trial to evaluate the safety and pharmacokinetics of raltegravir granules for suspension (GFS) with standard care PMTCT in full term HIV-1-exposed neonates.
Slovenian: IMPAACT P1110 je preskušanje I. faze za oceno varnosti in farmakokinetike zrnc raltegravirja za suspenzijo pri donošenih novorojenčkih, izpostavljenih HIV-1, ki so prejemali standardno zdravljenje s shemo PMTCT.
English: Uncommon skin papilloma
Slovenian: občasni kožni papilom
English: Because the extent to which raltegravir may be dialysable is unknown, dosing before a dialysis session should be avoided.
Slovenian: Ker obseg izločanja raltegravirja pri dializi ni znan, se je treba jemanju zdravila pred dializo izogibati.
English: (Increased drug solubility)
Slovenian: (večja topnost zdravila)
English: Raltegravir was administered as granules for oral suspension formulation without regard to food in combination with an optimised background regimen that included lopinavir plus ritonavir in two-thirds of patients.
Slovenian: Raltegravir so prejemali v obliki zrnc za peroralno suspenzijo ne glede na hrano, v kombinaciji z optimiziranim osnovnim režimom, ki je pri dveh tretjinah bolnikov vključeval lopinavir in ritonavir.
English: The expiry date is printed on the carton and the Isentress sachets.
Slovenian: Datum izteka roka uporabnosti je natisnjen na škatli in na vrečicah zdravila Isentress.
English: What Isentress is and what it is used for What you need to know before you take Isentress How to take Isentress
Slovenian: Kaj je zdravilo Isentress in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Isentress Kako jemati zdravilo Isentress
English: 3.0 mg/kg twice daily 23 14.3 (43.3%)
Slovenian: 3,0 mg/kg dvakrat na dan 23 14,3 (43,3 %)
English: Pour the leftover prepared Isentress into the rubbish.
Slovenian: Preostanek pripravljenega zdravila Isentress vlijte med odpadke.
English: • herpes infections including shingles
Slovenian: • okužba s herpesom, vključno s pasavcem
English: Maximum dose of oral suspension is 100 mg twice daily.
Slovenian: Največji odmerek peroralne suspenzije je 100 mg dvakrat dnevno.
English: This neoplasia could result from local deposition and/or aspiration of drug on the mucosa of the nose/nasopharynx during oral gavage dosing and subsequent chronic irritation and inflammation; it is likely that it is of limited relevance for the intended clinical use.
Slovenian: Te neoplazme so lahko posledica lokalnega odlaganja in/ali aspiracije v mukozo nosu/nazofarinksa med peroralnim dajanjem zdravila po cevki za hranjenje in posledičnega kroničnega draženja in vnetja.
English: Raltegravir readily crossed the placenta in rats, but did not penetrate the brain to any appreciable extent.
Slovenian: Pri podganah raltegravir z lahkoto prehaja preko placente, vendar pa v možgane ne prehaja v pomembnejšem obsegu.
English: Results 48-week and 240-week analyses
Slovenian: Rezultati 48-tedenske in 240-tedenske analize
English: If you are the parent or carer of a child taking Isentress, please read this information carefully.
Slovenian: Če ste starš ali skrbnik otroka, ki jemlje zdravilo Isentress, natančno preberite navodilo.
English: In randomised clinical trials raltegravir 400 mg twice daily was administered in combination with fixed or optimised background treatment regimens to treatment-naïve (N=547) and treatmentexperienced (N=462) adults for up to 96 weeks.
Slovenian: V randomiziranih kliničnih preskušanjih so raltegravir 400 mg dvakrat na dan dajali v kombinaciji s fiksnimi ali optimiziranimi osnovnimi režimi zdravljenja predhodno nezdravljenim (n = 547) in predhodno zdravljenim (n = 462) odraslim do 96 tednov.
English: ISENTRESS 600 mg film-coated tablet formulation should not be used in children weighing less than 40 kg.
Slovenian: Zdravila ISENTRESS 600 mg filmsko obložene tablete se ne sme uporabljati pri otrocih s telesno maso manj kot 40 kg.
English: Contains fructose, sorbitol and aspartame.
Slovenian: Vsebuje fruktozo, sorbitol in aspartam.
English: Neonates, Infants and Toddlers
Slovenian: Novorojenčki, dojenčki in malčki
English: Previous studies of raltegravir 400 mg twice daily showed that co-administration of tenofovir disoproxil fumarate (a component of emtricitabine/tenofovir disaproxil fumarate) increased raltegravir exposure.
Slovenian: Predhodne študije s 400 mg raltegravirja dvakrat na dan so pokazale, da sočasna uporaba tenofovirdizoproksil fumarata (sestavina kombinacije emtricitabin/tenofovirdizoproksil fumarat) poveča izpostavljenost raltegravirju.
English: There are no data for the use of raltegravir granules for oral suspension in pregnant women.
Slovenian: Ni podatkov o uporabi raltegravir zrnc za peroralno suspenzijo pri nosečnicah.
English: Each chewable tablet contains approximately 0.93 mg fructose, approximately 0.10 mg phenylalanine (as a component of aspartame) and approximately 2.8 mg sorbitol.
Slovenian: Ena žvečljiva tableta vsebuje približno 0,93 mg fruktoze, približno 0,10 mg fenilalanina (kot del aspartama) in približno 2,8 mg sorbitola.
English: In rats, tumours (squamous cell carcinoma) of the nose/nasopharynx were identified at 300 and 600 mg/kg/day in females and at 300 mg/kg/day in males.
Slovenian: Pri podganah so tumorje nosu/nazofarinksa (skvamoznocelični karcinom) odkrili pri samicah, ki so dobivale odmerke 300 in 600 mg/kg/dan in pri samcih, ki so dobivali odmerke 300 mg/kg/dan.
English: If at least 4 weeks of age and weighing at least 3 kg to less than 25 kg: Weight based dosing, as specified in Table 2.
Slovenian: Bolniki, stari najmanj 4 tedne, s telesno maso od najmanj 3 kg do manj kot 25 kg: odmerjanje temelji na telesni masi, kot kaže preglednica 2.
English: In treatment-naïve patients, the clinical study data on use of raltegravir are limited to use in combination with two nucleotide reverse transcriptase inhibitors (NRTIs) (emtricitabine and tenofovir disoproxil fumarate).
Slovenian: Za zdravljenje predhodno nezdravljenih bolnikov je iz kliničnih študij na voljo malo podatkov glede uporabe raltegravirja v kombinaciji z dvema nukleozidnima zaviralcema reverzne transkriptaze (NRTI) (emtricitabin in tenofovirdizoproksil fumarat).
English: Patients with chronic hepatitis B or C and treated with combination anti-retroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactions.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali kroničnim hepatitisom C, ki se zdravijo s kombiniranim protiretrovirusnim zdravljenjem, obstaja večje tveganje za pojav resnih in potencialno smrtnih neželenih učinkov na jetra.
English: • increased appetite; diabetes; increased blood cholesterol and lipids; high sugar levels in the blood; excessive thirst; severe weight loss; high levels of fat (such as cholesterol and triglycerides) in the blood; body fat disorder
Slovenian: • povečanje apetita, sladkorna bolezen, zvišani holesterol in lipidi v krvi, visoke vrednosti sladkorja v krvi, prekomerna žeja, huda izguba telesne mase, visoke vrednosti maščob (kot so holesterol in trigliceridi) v krvi, motnja prerazporeditve telesnega maščevja
English: Fill the blue syringe with water
Slovenian: 3. korak Modro brizgo napolnite z vodo
English: In clinical studies of treatment-experienced patients, rash, irrespective of causality, was more commonly observed with regimens containing raltegravir and darunavir compared to those containing raltegravir without darunavir or darunavir without raltegravir.
Slovenian: V kliničnih študijah pri že zdravljenih bolnikih so ne glede na vzrok izpuščaj pogosteje opazili pri bolnikih, ki so prejemali raltegravir in darunavir, kot pri bolnikih, ki so prejemali raltegravir brez darunavirja ali darunavir brez raltegravirja.
English: Depression, including suicidal ideation and behaviours, has been reported, particularly in patients with a pre-existing history of depression or psychiatric illness.
Slovenian: Poročali so o depresiji, vključno s samomorilnimi mislimi in obnašanjem, predvsem pri bolnikih, ki so imeli depresijo ali psihiatrično bolezen v anamnezi.
English: Cohort 1 (N=16, 10 exposed and 6 unexposed to raltegravir in utero) received 2 single doses of raltegravir GFS (within 48 hours and 7 - 10 days after birth); Cohort 2 (N=26, all raltegravir unexposed in utero) received raltegravir GFS for 6 weeks: 1.5 mg/kg once daily starting within 48 hours of birth through Week 1; 3 mg/kg twice daily Weeks 2 to 4; and 6 mg/kg twice daily Weeks 5 and 6.
Slovenian: Kohorta 1 (n = 16; 10 jih je bilo in utero izpostavljenih raltegravirju, 6 pa ne) je prejela 2 posamezna odmerka zrnc raltegravirja za peroralno suspenzijo (v 48 urah in od 7 do 10 dni po rojstvu); kohorta 2 (n = 26; nobeden od teh ni bil in utero izpostavljen raltegravirju) je prejemala zrnca raltegravirja za peroralno suspenzijo 6 tednov: 1,5 mg/kg enkrat na dan z začetkom v 48 urah po rojstvu v 1. tednu, 3 mg/kg dvakrat na dan od 2. do 4. tedna in 6 mg/kg dvakrat na dan 5. in 6. teden.
English: Excipients with known effect 100 mg
Slovenian: Pomožne snovi z znanim učinkom - 100 mg
English: • palpitations; slow heart rates; fast or irregular heart beats
Slovenian: • razbijanje srca (palpitacije), nizek srčni utrip, hitro ali neredno bitje srca
English: Slowly push up on the plunger to make the air come out.
Slovenian: Bat počasi potiskajte navzgor, tako da bo zrak šel ven.
English: Push the plunger into the barrel of the syringe as far as it goes.
Slovenian: Bat potisnite v telo brizge, kolikor daleč gre.
English: The doctor will work out the right dose of the chewable tablet based on the age and weight of the child.
Slovenian: Zdravnik bo določil pravilen odmerek žvečljivih tablet glede na starost in telesno maso otroka.
English: Raltegravir 1,200 mg once daily is also rapidly absorbed with median Tmax ~1.5 to 2 hours in the fasted state and generates a sharper absorption peak with a tendency to higher Cmax in comparison to raltegravir twice daily (1 x 400 mg tablet twice daily).
Slovenian: Raltegravir v odmerku 1.200 mg enkrat na dan se prav tako absorbira hitro - mediani tmax po uporabi na tešče je ~1,5 do 2 uri - in doseže ostrejši vrh absorpcije s težnjo k večji Cmax v primerjavi z raltegravirjem dvakrat na dan (ena 400-mg tableta dvakrat na dan).
English: Emtricitabine/tenofovir disaproxil fumarate was identified to increase raltegravir 1,200 mg once daily bioavailability by 12%, however its impact is not clinically meaningful.
Slovenian: Ugotovljeno je bilo, da kombinacija emtricitabin/tenofovirdizoproksil fumarat poveča biološko uporabnost 1.200 mg raltegravirja enkrat na dan za 12 %, vendar njen vpliv ni klinično pomemben.
English: Adverse reactions Raltegravir (alone or in combination with other ART)
Slovenian: Neželeni učinki raltegravir (sam ali v kombinaciji z drugimi protiretrovirusnimi zdravili)
English: • rifampicin (a medicine used to treat some infections such as tuberculosis), as it may decrease your levels of Isentress.
Slovenian: • rifampicin (zdravilo za zdravljenje nekaterih okužb, kot je tuberkuloza), ker lahko zniža koncentracijo zdravila Isentress v krvi.
English: Mutations conferring resistance to raltegravir generally also confer resistance to the integrase strand transfer inhibitor elvitegravir.
Slovenian: Mutacije, povezane z odpornostjo proti raltegravirju, so običajno povezane tudi z odpornostjo proti zaviralcu prenosa zapisa integraze elvitegravirju.
English: Of the 126 patients, 96 received the recommended dose of raltegravir (see section 4.2).
Slovenian: Izmed 126 bolnikov jih je 96 prejemalo priporočeni odmerek raltegravirja (glejte poglavje 4.2).
English: The treatment difference (raltegravir - efavirenz) was 4.2 % with an associated 95 % CI of (-1.9, 10.3) establishing that raltegravir is non-inferior to efavirenz (pvalue for non-inferiority < 0.001).
Slovenian: Razlika v zdravljenju (raltegravir - efavirenz), ki je bila 4,2 % pri upoštevanju 95-odstotnega intervala zaupanja (-1,9, 10,3), je pokazala, da raltegravir ni inferioren v primerjavi z efavirenzem (p-vrednost za neinferiornost < 0,001).
English: Isentress 600 mg film-coated tablets is used to treat adults and paediatric patients weighing at least 40 kg who are infected by HIV.
Slovenian: Zdravilo Isentress 600 mg filmsko obložene tablete se uporablja za zdravljenje odraslih in pediatričnih bolnikov s telesno maso najmanj 40 kg, okuženih z virusom HIV.
English: In both studies at Week 24, suppression of HIV RNA to less than 50 copies/mL was maintained in 84.4 % of the raltegravir group versus 90.6 % of the lopinavir (+) ritonavir group, (Non-completers = Failure).
Slovenian: V obeh študijah se je v 24. tednu supresija HIV RNA na manj kot 50 kopij/ml ohranila pri 84,4 % bolnikov v skupini, ki je prejemala raltegravir, in pri 90,6 % bolnikov v skupini, ki je prejemala lopinavir (+) ritonavir (z uporabo metode nedokončanje = neuspeh).
English: After reconstitution: 30 minutes when stored at or below 30 C.
Slovenian: Zaprta vrečica: 2 leti Po pripravi: 30 minut pri shranjevanju pri temperaturi do največ 30 °C.
English: You can take this medicine with or without food or drink.
Slovenian: To zdravilo lahko jemljete skupaj s hrano ali pijačo ali brez.
English: These findings can be extended to raltegravir 1,200 mg once daily and no dosage adjustment is required for these agents.
Slovenian: Te izsledke je mogoče prenesti na 1.200 mg raltegravirja enkrat na dan in zato odmerka teh učinkovin ni treba prilagoditi.
English: There were no drug related clinical adverse experiences and three drug-related laboratory adverse experiences (one a transient Grade 4 neutropenia in a subject receiving zidovudine containing prevention of mother to child transmission (PMTCT), and two bilirubin elevations (one each, Grade 1 and Grade 2) considered non-serious and not requiring specific therapy).
Slovenian: Ugotovili niso nobenih z zdravilom povezanih kliničnih neželenih učinkov, zabeležili pa so tri z zdravilom povezane laboratorijske neželene učinke (en primer prehodne nevtropenije 4. stopnje pri prejemniku sheme za preventivo prenosa z matere na otroka (PMTCT), ki je vključevala zidovudin, ter dva primera zvišanja bilirubina (enega 1. in enega 2. stopnje), za katera je bilo ocenjeno, da nista resna in nista zahtevala specifičnega zdravljenja).
English: Of the 126 patients, 96 received the recommended dose of raltegravir.
Slovenian: Izmed 126 bolnikov jih je 96 prejelo priporočeni odmerek raltegravirja.
English: Uncommon palpitations, sinus bradycardia, ventricular extrasystoles
Slovenian: Srčne bolezni občasni palpitacije, sinusna bradikardija, ventrikularne ekstrasistole
English: Therefore, when raltegravir is co-administered with calcium carbonate containing antacids no dose adjustment is required.
Slovenian: Zato pri sočasni uporabi raltegravirja z antacidi, ki vsebujejo kalcijev karbonat, odmerka ni potrebno prilagoditi.
English: • 2 mixing cups
Slovenian: • 2 posodici za mešanje
English: Your doctor has prescribed Isentress to help control your HIV infection.
Slovenian: Zdravnik vam je zdravilo Isentress predpisal, da bi zdravilo pomagalo obvladovati okužbo z virusom HIV.
English: ISENTRESS 600 mg tablets can be administered with or without food as a 1,200 mg once daily dose.
Slovenian: Zdravilo ISENTRESS 600 mg tablete se lahko jemlje s hrano ali brez v odmerku 1.200 mg enkrat na dan.
English: Co-administration of raltegravir with aluminium and/or magnesium antacids is not recommended (see section 4.5).
Slovenian: Sočasna uporaba raltegravirja z aluminijevimi in/ali magnezijevimi antacidi ni priporočljiva (glejte poglavje 4.5).
English: What you need to know before you take Isentress
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Isentress
English: In patients, after 1,200 mg once daily raltegravir dosing, steady state AUC0-24 was 53.7 h·μM, C24 was 75.6 nM, and median Tmax was 1.50 h.
Slovenian: Po uporabi 1.200 mg raltegravirja enkrat na dan so bili pri bolnikih AUC0-24 v stanju dinamičnega ravnovesja 53,7 h·µM, C24 75,6 nM in mediani tmax 1,50 ure.
English: Hand wash the syringes, plungers, and mixing cup with warm water and dishwashing soap.
Slovenian: Brizge, bate in posodico za mešanje operite na roke s toplo vodo in sredstvom za pranje posode.
English: Population pharmacokinetic analysis from ONCEMRK (Protocol 292) showed that co-administration of raltegravir 1,200 mg once daily with PPIs or H2 blockers did not result in statistically significant changes in the pharmacokinetics of raltegravir.
Slovenian: Populacijska farmakokinetična analiza v študiji ONCEMRK (protokol 292) je pokazala, da sočasna uporaba 1.200 mg raltegravirja enkrat na dan z zaviralci protonske črpalke ali antagonisti histaminskih receptorjev H2 ne povzroči statistično značilnih sprememb v farmakokinetiki raltegravirja.
English: The rates of discontinuation of raltegravir due to adverse reactions were 5% or less in clinical trials.
Slovenian: V kliničnih preskušanjih so bile stopnje prekinitve zdravljenja z raltegravirjem zaradi neželenih učinkov 5 % ali manj.
English: It also lowers the chance that your medicines will stop being able to fight HIV (also called "drug resistance").
Slovenian: Na ta način bo delovanje vseh zdravil boljše, možnost, da zdravila proti virusu HIV ne bi pomagala (kar imenujemo tudi odpornost na zdravilo) pa je pri tem manjša.