FrancophonIA/ELRC3.0 huggingface dataset:
English: If flu-like symptoms or feeling discomfort or intense local skin reactions occur, a rest period of several days may be taken.
Croatian: Ako se pojave simptomi nalik gripi ili osjećaj nelagode ili intenzivne lokalne kožne reakcije, može se prekinuti primjena na nekoliko dana.
English: Studies in rabbits reveal a dermal lethal imiquimod dose of greater than 5 g/kg.
Croatian: Ispitivanja na kunićima pokazala su da je kožna letalna doza imikvimoda veća od 5 g/kg.
English: Data presented in the table below reflects: - exposure to Zyclara or vehicle in above mentioned studies (frequencies very common to uncommon and at greater frequency after vehicle).
Croatian: Podaci prikazani u tablici ispod odražavaju: - izloženost Zyclari ili podlozi u gore navedenim ispitivanjima (vrlo česte do manje česte učestalosti i s većom učestalošću u odnosu na podlogu)
English: Information on re-treating actinic keratosis lesions that have cleared after two Zyclara treatment cycles of 2 weeks and subsequently recur is given in section 4.2 and 5.1.
Croatian: Ponovno liječenje Podaci o ponovnom liječenju lezija aktinične keratoze koje su nestale nakon dvaju ciklusa liječenja lijekom Zyclara u trajanju od 2 tjedna te se poslije ponovno javile navedeni su u dijelovima 4.2 i 5.1.
English: - Each box contains 14, 28 or 56 single-use polyester/ white low density polyethylene/aluminium foil sachets.
Croatian: - Svaka kutija sadrži 14, 28 ili 56 vrećica za jednokratnu primjenu od poliestera/bijelog polietilena niske gustoće/aluminijske folije.
English: Influenza-like illness Pain
Croatian: - simptomi slični gripi
English: Alfred Gera and Sons Ltd. 10,Triq il -Masgar Qormi QRM3217
Croatian: 10,Triq il -Masgar Qormi QRM3217
English: Mylan Healthcare Sp. z o.o.
Croatian: PolskaMylan Healthcare Sp. z o.o.
English: Due to its immunostimulating properties, imiquimod cream should be used with caution in patients who are receiving immunosuppressive medicinal products (see section 4.4).
Croatian: Imikvimod kremu potrebno je zbog njenih imunostimulirajućih značajki upotrebljavati s oprezom u bolesnika koji primaju imunosupresivne lijekove (vidjeti dio 4.4).
English: Benzyl alcohol may cause allergic reactions and mild local irritation.
Croatian: Benzilni alkohol može uzrokovati alergijske reakcije i blagi lokalno nadražaj.
English: Actinic keratosis lesions that have cleared after two Zyclara treatment cycles of 2 weeks and subsequently recur can be re-treated with one or two further Zyclara treatment cycles of 2 weeks following an at least 12 weeks treatment pause.
Croatian: Lezije aktinične keratoze koje su nestale nakon dva dvotjedna ciklusa liječenja lijekom Zyclara i koje su se naknadno ponovno pojavile mogu se ponovno liječiti jednim ili dvama dodatnim ciklusima liječenja lijekom Zyclara nakon barem 12 tjedana pauze.
English: Do not cover the treated area with bandages or other dressings.
Croatian: Ne pokrivajte liječeno područje zavojima ili drugim pokrivalima.
English: Boxes of 14, 28, and 56 single-use polyester/ white low density polyethylene/ aluminium foil sachets, containing 250 mg of cream.
Croatian: Kutije s 14, 28 i 56 vrećica za jednokratnu primjenu od poliestera/bijelog polietilena niske gustoće/aluminijske folije, koje sadrže 250 mg kreme.
English: If you accidentally swallow this medicine please contact your doctor immediately.
Croatian: Ako slučajno progutate ovaj lijek odmah se obratite svom liječniku.
English: - Increase in liver enzymes There have been reports of increased liver enzymes.
Croatian: Bilo je prijava povišenja jetrenih enzima.
English: You should continue application for the full treatment course even if all actinic keratosis appear to be gone.
Croatian: Nužno je nastaviti primjenu u punom trajanju liječenja, čak i ako se čini da je sva aktinična keratoza nestala.
English: This medicine should only be used for actinic keratosis on the face and scalp.
Croatian: Ovaj lijek smije se koristiti samo za aktiničnu keratozu lica i tjemena.
English: You should continue treatment as prescribed.
Croatian: Nužno je nastaviti liječenje kako je propisano.
English: Skin infection
Croatian: Kožne infekcije
English: For the combined trials the complete clearance rate of the full face or balding scalp under imiquimod 3.75% cream was 35.6% (57/160 patients, CI 28.2%, 43.6 %) under vehicle 6.3% (10/159 patients, CI 3.1%, 11.3%) at the 8-week post-treatment visit.
Croatian: U kombiniranim ispitivanjima je stopa potpunog nestanka lezija s cijelog lica ili tjemena bez kose s imikvimod 3,75% kremom bila 35,6 % (57/160 bolesnika, CI 28,2%; 43,6%), a s podlogom 6,3% (10/159 bolesnika, CI 3,1%; 11,3%)
English: Your doctor will discuss if you should discontinue breastfeeding or discontinue Zyclara treatment.
Croatian: Vaš će liječnik razmotriti trebate li prestati dojiti ili prekinuti liječenje lijekom
English: The treatment area should not be bandaged or otherwise occluded.
Croatian: Liječeno područje se ne smije prekrivati zavojem ni okludirati na neki drugi način.
English: Whilst using Zyclara and until healed, the treatment area is likely to appear noticeably different from normal skin.
Croatian: Dok primjenjujete Zyclaru i dok područje koje se liječi ne zacijeli, ono će vjerojatno izgledati primjetno drugačije od normalne kože.
English: If you stop using Zyclara
Croatian: Ako prestanete primjenjivati Zyclaru
English: Tumours occurred earlier and in greater number in the group of mice administered the vehicle cream in comparison with the low UVR control group.
Croatian: Tumori su se javili ranije i u većem broju u skupini miševa na kojoj je primijenjena krema od same podloge u usporedbi s kontrolnom skupinom s niskim
English: In addition, release of cytokines was induced following dermal application and oral administration of imiquimod in various laboratory animals and in human studies.
Croatian: Uz to, otpuštanje citokina bilo je inducirano nakon kožne primjene i oralne primjene imikvimoda u različitih laboratorijskih životinja te u ispitivanjima u ljudi.
English: Patients with reduced haematologic reserve should be monitored under the close supervision of an experienced physician (see section 4.8).
Croatian: Bolesnike sa smanjenom hematološkom rezervom mora pažljivo nadzirati iskusan liječnik (vidjeti dio
English: Dolenjska cesta 242c 1000 Ljubljana Tel: +386 1 23 63 180
Croatian: GSP Proizvodi d.o.o. Dolenjska cesta 242c 1000 Ljubljana Tel: +386 1 23 63 180
English: If you forget to use Zyclara
Croatian: Ako ste zaboravili primijeniti Zyclaru
English: You could resume treatment with imiquimod cream after the skin reaction has moderated.
Croatian: Možete nastaviti liječenje imikvimod kremom nakon što se kožna reakcija ublaži.
English: Via Felice Casati, 20 20124 Milano Tel: +39 039 73901
Croatian: Meda Pharma S.p.A. Via Felice Casati, 20 20124 Milano Tel: +39 039 73901
English: Up to 2 sachets of Zyclara may be applied to the treatment area (full face or scalp, but not both) at each daily application.
Croatian: Mogu se primijeniti do 2 vrećice Zyclare svakoga dana primjene na područje liječenja (cijelo lice ili tjeme, ali ne oboje).
English: Zyclara is indicated for the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic, visible or palpable actinic keratosis (AK) of the full face or balding scalp in immunocompetent adults when other topical treatment options are contraindicated or less appropriate.
Croatian: vidljivih ili palpabilnih aktiničnih keratoza (AK) cijelog lica ili tjemena bez kose u odraslih imunokompetentnih bolesnika kada su druge mogućnosti topikalnog liječenja kontraindicirane ili manje prikladne.
English: Zyclara (per application: up to 2 sachets, 250 mg imiquimod cream per sachet) should be applied once daily before bedtime to the skin of the affected treatment field (area) for two treatment cycles of 2 weeks each separated by a 2-week no-treatment cycle or as directed by the physician.
Croatian: Zyclaru (do 2 vrećice po nanošenju, 250 mg imikvimod kreme po vrećici) je potrebno nanositi jednom dnevno prije spavanja na kožu zahvaćenog područja koje se liječi tijekom dvaju ciklusa liječenja od 2 tjedna, između kojih je dvotjedni ciklus bez liječenja ili prema uputi liječnika.
English: Because of concern for heightened sunburn susceptibility, use of sunscreen is encouraged, and patients should minimise or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment) while using Zyclara.
Croatian: Bolesnici bi trebali smanjiti na najmanju moguću mjeru ili izbjegavati izlaganje prirodnom ili umjetnom sunčevom svjetlu (odlazak u solarije ili UVA/B liječenje) tijekom liječenja Zyclarom.
English: Reductions in haematological parameters requiring clinical intervention have been reported from postmarketing experience.
Croatian: Nakon stavljanja u promet prijavljena su sniženja hematoloških parametara koja su zahtijevala kliničku intervenciju.
English: Skin infections during treatment with imiquimod have been observed.
Croatian: Tijekom liječenja imikvimodom opažene su kožne infekcije.
English: - Each Zyclara 3.75% cream sachet contains 250 mg of a white to slightly yellow cream with a uniform appearance.
Croatian: - Svaka vrećica Zyclara 3,75% kreme sadrži 250 mg bijele do žućkaste kreme jednoličnog izgleda.
English: Cetyl alcohol and stearyl alcohol may cause local skin reactions (e.g. contact dermatitis).
Croatian: Cetilni alkohol i stearilni alkohol mogu prouzročiti lokalne kožne reakcije (npr. kontaktni dermatitis).
English: During a pharmacokinetic study with imiquimod 3.75% cream following application of 2 sachets once daily (18.75 mg imiquimod/day) for up to three weeks to the entire face and/or scalp (approximately 200 cm2), low systemic absorption of imiquimod was observed in patients with AK. Steady-state levels were achieved in 2 weeks and time to maximal concentrations (Tmax) ranged between 6 and 9 hours after last application.
Croatian: Tijekom farmakokinetičkog ispitivanja s imikvimod 3,75% kremom nakon primjene 2 vrećice jedanput dnevno (18,75 mg imikvimoda/dan) tijekom do tri tjedna na cijelo lice i/ili tjeme (približno 200 cm2), opažena je niska sistemska apsorpcija imikvimoda u bolesnika s AK-om.
English: Patients with cardiac, hepatic or renal impairment were not included in clinical trials.
Croatian: Bolesnici s oštećenjem srca, jetre ili bubrega nisu bili uključeni u klinička ispitivanja.
English: - Throat pain - Eye irritation - Swelling of the eyelid - Depression - Irritability - Dry mouth - Abdominal pain
Croatian: - oticanje kapka - depresija - razdražljivost - suha usta - bol u trbuhu
English: • Avoid contact with the eyes, lips and nostrils.
Croatian: • Izbjegavajte kontakt s očima, usnama i nosnicama.
English: Treatment with imiquimod cream can be resumed after the skin reaction has moderated.
Croatian: Liječenje imikvimod kremom može se nastaviti nakon što se kožna reakcija ublaži.
English: Stearyl alcohol and cetyl alcohol may cause local skin reactions (e.g. contact dermatitis).
Croatian: Stearilni alkohol i cetilni alkohol mogu prouzročiti lokalne kožne reakcije (npr. kontaktni dermatitis).
English: In a follow-up study where initially cleared patients with imiquimod 3.75% were followed for at least 14 months without any further AK-treatment, 40.5% of the patients showed sustained complete clearance of the whole treatment area (either full face or scalp) There are no data for imiquimod 3.75% on long-term clearance beyond that.
Croatian: Tijekom ispitivanja u kojem su bolesnici početno izliječeni imikvimodom 3,75% praćeni najmanje 14 mjeseci bez ikakvog daljnjeg liječenja AK, 40,5% bolesnika pokazalo je održani potpuni nestanak lezija cijelog liječenog područja (ili cijelo lice ili tjeme).
English: For imiquimod no clinical data on exposed pregnancies are available.
Croatian: Nisu dostupni klinički podaci o izloženosti imikvimodu u trudnica.
English: Methyl parahydroxybenzoate (E 218), and propyl parahydroxybenzoate (E 216), may cause allergic reactions (possibly delayed).
Croatian: Metilparahidroksibenzoat (E 218) i propilparahidroksibenzoat (E 216) mogu prouzročiti alergijske reakcije (moguće odgođene).
English: Zyclara contains methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol
Croatian: Zyclara sadrži metilparahidroksibenzoat, propilparahidroksibenzoat, cetilni alkohol, stearilni alkohol i benzilni alkohol
English: C/ Plom, 2-4, 5ª planta 08038 - Barcelona Tel: +34 900 102 712
Croatian: Mylan Pharmaceuticals, S.L. C/ Plom, 2-4, 5ª planta 08038 - Barcelona Tel: +34 900 102 712
English: Rare (≥ 1/10,000 to < 1/1,000);
Croatian: Rijetko (≥ 1/10 000 do < 1/1000)
English: Each sachet contains 9.375 mg of imiquimod in 250 mg cream (3.75%).
Croatian: Svaka vrećica sadrži 9,375 mg imikvimoda u 250 mg kreme (3,75%).
English: You should not use Zyclara if you are breast-feeding or plan to breast-feed.
Croatian: Ne smijete koristiti lijek Zyclara ako dojite ili planirate dojiti.
English: Zyclara 3.75% cream
Croatian: Zyclara 3,75% krema
English: Squamous cell carcinoma (SCC) was reported in 1.3% (2/160) of patients treated with imiquimod 3.75%, in 0.6% (1/159) treated with vehicle.
Croatian: Karcinom skvamoznih stanica je prijavljen u 1,3% (2/160) bolesnika liječenih imikvimodom 3,75%, a u 0,6% (1/159) bolesnika koji su primali podlogu.
English: Chaussée de la Hulpe 166 Terhulpsesteenweg B-1170 Brussels Belgique / Belgien Tél/Tel: +32 (0)2 5 04 08 11
Croatian: Meda Pharma S.A./N.V. Chaussée de la Hulpe 166 Terhulpsesteenweg B-1170 Brussels Belgique / Belgien Tél/Tel: +32 (0)2 5 04 08 11
English: Subjects applied up to two sachets of Zyclara 3.75% cream or vehicle daily to the skin of the affected area (either entire face or balding scalp, but not both) for two 2-week treatment cycles separated by a 2-week no-treatment cycle.
Croatian: Ispitanici su primjenjivali do dvije vrećice Zyclara 3,75% kreme ili podloge dnevno na kožu zahvaćenog područja (ili cijelo lice ili tjeme bez kose, ali ne oboje) tijekom dvaju dvotjednih ciklusa liječenja odvojenih dvotjednim ciklusom bez liječenja.
English: Medicinal product subject to medicinal prescription.
Croatian: Lijek se izdaje na recept.
English: Hepatic enzyme increased
Croatian: - povišenje jetrenih enzima
English: Each treatment cycle should not be extended beyond 2 weeks due to missed doses or rest periods.
Croatian: Nijedan ciklus liječenja se ne smije produljiti na više od 2 tjedna zbog propuštene doze ili razdoblja odmora.
English: When applied topically, systemic overdose with imiquimod cream is unlikely due to minimal percutaneous absorption.
Croatian: Sistemsko predoziranje imikvimod kremom nije vjerojatno kada se primjenjuje topikalno zbog minimalne perkutane apsorpcije.
English: How to use Zyclara
Croatian: Kako primjenjivati Zyclaru
English: However, neither 2-week treatment cycle should be extended due to missed doses or rest periods.
Croatian: Međutim, nijedan dvotjedni ciklus liječenja se ne smije produljiti zbog propuštenih doza ili razdoblja odmora.
English: Topical administration of imiquimod cream resulted in no tumour enhancement at any dose, in comparison with the vehicle cream group.
Croatian: Topikalna primjena imikvimod kreme nije rezultirala povećanjem broja tumora pri bilo kojoj dozi u usporedbi sa skupinom na kojoj je primijenjena krema od same podloge.
English: Package leaflet: Information for the user Zyclara 3.75% cream
Croatian: Uputa o lijeku: Informacije za korisnika Zyclara 3,75% krema imikvimod
English: Common (≥ 1/100 to < 1/10);
Croatian: Često (≥ 1/100 do < 1/10)
English: Avoid contact with the eyes, lips and nostrils.
Croatian: Izbjegavajte dodir s očima, usnama i nosnicama.
English: United Kingdom.
Croatian: Ujedinjeno Kraljevstvo
English: Τηλ: +30 210 6 77 5690
Croatian: Αγίου Δημητρίου 63 17456 Άλιμος Τηλ: +30 210 6 77 5690
English: Discard any cream remaining in a sachet after use.
Croatian: Bacite svu kremu preostalu u vrećici nakon primjene.
English: In a four-month rat dermal toxicity study, significantly decreased body weight and increased spleen weight were observed at 0.5 and 2.5 mg/kg; similar effects were not seen in a four-month mouse dermal study.
Croatian: U četveromjesečnom ispitivanju kožne toksičnosti na štakorima opaženo je značajno smanjenje tjelesne težine i povećanje težine slezene pri 0,5 i 2,5 mg/kg.
English: Blood system disorders
Croatian: Poremećaji krvi
English: - The other ingredients are isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), xanthan gum, purified water (see also section 2 “Zyclara contains methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol, stearyl alcohol and benzyl alcohol”).
Croatian: - Drugi sastojci su izostearatna kiselina, benzilni alkohol, cetilni alkohol, stearilni alkohol, bijeli vazelin, polisorbat 60, sorbitanstearat, glicerol, metilparahidroksibenzoat (E218), propilparahidroksibenzoat (E216), ksantanska guma, pročišćena voda (vidjeti također dio 2. „Zyclara sadrži metilparahidroksibenzoat, propilparahidroksibenzoat, cetilni alkohol, stearilni alkohol i benzilni alkohol“).
English: If your skin reacts badly or becomes too uncomfortable when using this medicine, stop applying the cream and wash the area with mild soap and water.
Croatian: Vam postane previše nelagodno pri primjeni ovog lijeka, prekinite primjenu kreme i operite područje blagim sapunom i vodom.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS SACHET TEXT
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE
English: How to store Zyclara
Croatian: Kako čuvati Zyclaru
English: System organ class
Croatian: Klasifikacija organskih sustava Učestalost
English: Mylan Healthcare B.V. Krijgsman 20
Croatian: Mylan Healthcare B.V.
English: Rarely, intense local inflammatory reactions including skin weeping or erosion can occur after only a few applications of imiquimod cream.
Croatian: uključujući vlaženje kože ili erozije, rijetko se mogu javiti nakon samo nekoliko primjena imikvimod kreme.
English: Excipients: isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), xanthan gum, purified water.
Croatian: Pomoćne tvari: izostearatna kiselina, benzilni alkohol, cetilni alkohol, stearilni alkohol, bijeli vazelin, polisorbat 60, sorbitanstearat, glicerol, metilparahidroksibenzoat (E 218), propilparahidroksibenzoat (E 216), ksantanska guma, pročišćena voda.
English: Anorexia Blood glucose increased
Croatian: Poremećaji metabolizma i prehrane često anoreksija povišena glukoza u krvi
English: A different therapy is recommended if the treated lesion(s) show(s) insufficient response to Zyclara.
Croatian: Preporučuje se neka druga terapija ako liječene lezije ne reagiraju na odgovarajući način na lijek
English: A. MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Croatian: PRILOG II. A. PROIZVOĐAČI ODGOVORNI ZA PUŠTANJE SERIJE LIJEKA U PROMET
English: • If the treated site becomes too uncomfortable, wash the cream off with mild soap and water.
Croatian: • Ako na liječenom mjestu osjećate preveliku nelagodu, isperite kremu s blagim sapunom i vodom.
English: Zyclara 3.75% cream imiquimod
Croatian: Zyclara 3,75% krema imikvimod
English: Contact with eyes, lips, and nostrils should be avoided.
Croatian: Potrebno je izbjegavati kontakt s očima, usnama i nosnicama.
English: Following accidental ingestion, nausea, emesis, headache, myalgia and fever could occur after a single dose of 200 mg imiquimod which corresponds to the content of more than 21 sachets of Zyclara.
Croatian: Nakon slučajnog gutanja jedne doze od 200 mg imikvimoda što odgovara sadržaju od više od 21
English: and rash - Swollen glands - Headache - Dizziness - Loss of appetite - Nausea - Diarrhoea - Vomiting - Flu-like symptoms - Fever - Pain - Muscle and joint pain - Chest pain - Insomnia - Tiredness - Viral infection (herpes simplex) - Increase in blood glucose
Croatian: - bol u prsnom košu - nesanica - umor - virusna infekcija (herpes simplex) - povišenje glukoze u krvi
English: Uncommon (≥ 1/1,000 to < 1/100);
Croatian: Manje često (≥ 1/1000 do < 1/100)
English: Mylan Pharmaceuticals, S.L.
Croatian: Mylan Products Ltd.
English: Very common (may affect more than 1 in 10 people) - Skin redness, scabbing, skin scaling, discharge, skin dryness, skin swelling, skin ulcer, and reduced skin pigmentation at the application site
Croatian: - crvenilo kože, stvaranje krasta, ljuštenje kože, iscjedak, suhoća kože, oticanje kože, vrijed kože i smanjena pigmentacija kože na mjestu primjene Često (mogu se javiti u do 1 na 10 osoba):
English: Reductions in haemoglobin, white blood cell count, absolute neutrophils and platelets have been observed in clinical trials investigating the use of imiquimod 5% cream.
Croatian: U kliničkim ispitivanjima koja su istraživala primjenu imikvimod 5% kreme opažena su sniženja hemoglobina, broja bijelih krvnih stanica, apsolutnog broja neutrofila i trombocita.
English: Tel: +420 222 004 400
Croatian: 100 10 Praha 10 Tel: +420 222 004 400
English: Uncommon (may affect up to 1 in 100 people) - Changes at the application site, e.g. bleeding, small swollen areas in the skin, inflammation, pins and needles, increased sensitivity to touch, scarring, feeling of warmth, skin breakdown, blisters or pustules - Weakness - Shivering - Lack of energy (lethargy) - Discomfort - Swelling of the face - Back pain - Pain in limbs - Stuffy nose
Croatian: - promjene na mjestu primjene, npr. krvarenje, mala otečena područja u koži, upala, trnci i bockanje, povećana osjetljivost na dodir, nastajanje ožiljaka, osjećaj topline, pucanje kože, mjehurići ili gnojni mjehurići
English: Talk to your doctor or pharmacist before using Zyclara:
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primijenite Zyclaru: • ako ste prije primjenjivali ovaj lijek ili slične pripravke u drugačijoj koncentraciji.
English: 319 subjects with AK were treated with up to 2 sachets once daily of imiquimod 3.75% cream, or a matching vehicle cream for two treatment cycles of 2 weeks separated by a 2-week no-treatment cycle.
Croatian: 3,75% kreme jedanput dnevno ili s odgovarajućom kremom od podloge u dva ciklusa liječenja u trajanju od 2 tjedna, odvojena dvotjednim ciklusom bez liječenja.
English: Nervous system disorders
Croatian: Poremećaji živčanog sustava često glavobolja omaglica
English: Rare cases of remote site dermatologic reactions, including erythema multiforme, have been reported from clinical trials with imiquimod 5% cream therapy.
Croatian: U kliničkim ispitivanjima imikvimod 5% kreme su prijavljeni rijetki slučajevi kožnih reakcija na udaljenom mjestu uključujući eritema multiforme.
English: The mean peak serum imiquimod concentration at the end of the pharmacokinetic study was 0.323 ng/mL.
Croatian: Srednja vršna koncentracija imikvimoda u serumu na kraju farmakokinetičkog ispitivanja bila je
English: Headache Dizziness
Croatian: - začepljen nos
English: Haemoglobin decreased White blood cell count decreased Neutrophil count decreased Platelet count decreased
Croatian: Poremećaji krvi i limfnog sustava često limfadenopatija učestalost nepoznata sniženi hemoglobin sniženi broj bijelih krvnih stanica sniženi broj neutrofila sniženi broj trombocita
English: Conjunctival irritation Eyelid oedema
Croatian: Poremećaji oka manje često iritacija konjunktive edem kapaka
English: In these studies, the treated AK field was located on the balding scalp or face with a contiguous area of about 40 cm² and presenting with a median number of 7 clinically typical AK lesions at baseline.
Croatian: U ovim ispitivanjima liječeno AK područje bilo je smješteno na tjemenu bez kose ili licu s ukupnim područjem od oko 40
English: Very common (≥ 1/10);
Croatian: Učestalosti su definirane kao: Vrlo često (≥ 1/10)
English: Frequency not known (frequency cannot be estimated from the available data) - Changes in skin colour Some patients have experienced changes in skin colour in the area where Zyclara was applied.
Croatian: Neki bolesnici su iskusili promjene boje kože u području na kojem je bila primjenjivana