FrancophonIA/ELRC3.0 huggingface dataset:
English: The degree of benefit of this nucleoside combination in heavily pre-treated patients will depend on the nature and duration of prior therapy that may have selected for HIV-1 variants with cross-resistance to abacavir, lamivudine or zidovudine.
Slovenian: Stopnja koristnosti te kombinacije nukleozidov pri predhodno intenzivno zdravljenih bolnikih je odvisna od vrste in trajanja predhodnega zdravljenja, ki je lahko povzročilo selekcijo HIV-1 variant z navzkrižno rezistenco na abakavir, lamivudin ali zidovudin.
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited binding to the major plasma protein albumin (< 36 % serum albumin in vitro).
Slovenian: Lamivudin izkazuje linearno farmakokinetiko v terapevtskem razponu odmerjanja in se le omejeno veže na glavni plazemski protein albumin (< 36 % serumskega albumina in vitro).
English: A subsequent intravaginal carcinogenicity study confirmed the hypothesis that the vaginal tumours were the result of long term local exposure of the rodent vaginal epithelium to high concentrations of unmetabolised zidovudine in urine.
Slovenian: Nadaljnja raziskava intravaginalne karcinogenosti je potrdila hipotezo, da so vaginalni tumorji posledica dolgoročne lokalne izpostavljenosti vaginalnega epitela samic glodalcev visokim koncentracijam nemetaboliziranega zidovudina v urinu.
English: Abacavir HSR has been well characterised through clinical studies and during post marketing followup.
Slovenian: HSR na abakavir so dobro opredelili v kliničnih študijah in med obdobjem spremljanja po prihodu zdravila na trg.
English: The systemic exposures were equivalent to 7 to 24 times the expected systemic exposure in humans.
Slovenian: Sistemske izpostavljenosti so bile ekvivalentne 7-kratni do 24-kratni sistemski izpostavljenosti,
English: Some medicines interact with Trizivir These include:
Slovenian: Nekatera zdravila medsebojno delujejo z zdravilom Trizivir Med takšnimi so:
English: • if they are overweight
Slovenian: • ki so pretežki.
English: Read the information ‘Other possible side effects of Trizivir' in Section 4 of this leaflet.
Slovenian: Preberite informacije "Drugi možni neželeni učinki zdravila Trizivir" v poglavju 4 tega navodila.
English: Overall, the virologic suppression with this triple nucleoside regimen could be inferior to that obtained with other multitherapies notably including boosted Protease inhibitors or non nucleoside reverse transcriptase inhibitors, therefore the use of Trizivir should only be considered under special circumstances (e.g. co-infection with tuberculosis).
Slovenian: V celoti je lahko virološka supresija s to trojno nukleozidno shemo slabša od tiste, ki je dosežena z drugimi shemami več zdravil, zlasti vključno z okrepljenimi zaviralci proteaz ali nenukleozidnimi zaviralci reverzne transkriptaze, zato pride uporaba zdravila Trizivir v poštev le v posebnih okoliščinah (npr. v primeru sočasne okužbe s tuberkulozo).
English: Patients should be advised that Trizivir or any other antiretroviral therapy does not cure HIV infection and that they may still develop opportunistic infections and other complications of HIV infection.
Slovenian: Bolnikom je potrebno pojasniti, da zdravilo Trizivir ali katero koli drugo protiretrovirusno zdravilo okužbe z virusom HIV ne ozdravi, zato se še vedno lahko pojavijo oportunistične okužbe in drugi zapleti vezani na okužbo z virusom HIV.
English: Likewise, neither lamivudine nor zidovudine had any effect on fertility.
Slovenian: Prav tako niti lamivudin niti zidovudin nista vplivala na plodnost.
English: • skin rash, which may form blisters and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) (erythema multiforme)
Slovenian: • izpuščaj na koži, ki lahko oblikuje mehurje in daje videz majhnih tarč (temnih osrednjih točk, ki jih obdaja svetlejši predel, obdan s temnim robom) (multiformni eritem),
English: Because insufficient data are available, the use of Trizivir in children or adolescents is not recommended.
Slovenian: Zaradi nezadostnih podatkov, uporaba zdravila Trizivir pri otrocih ali mladostnikih ni priporočljiva.
English: When you are being treated for HIV, it can be hard to tell whether a symptom is a side effect of Trizivir or other medicines you are taking, or an effect of the HIV infection itself.
Slovenian: Med zdravljenjem okužbe s HIV je težko reči, ali je nek simptom neželen učinek zdravila Trizivir, neželen učinek drugih zdravil, ki jih jemljete, ali posledica same okužbe s HIV.
English: Women who are HIV-positive must not breast-feed, because HIV infection can be passed on to the baby in breast milk.
Slovenian: Dojenje HIV-pozitivne ženske ne smejo dojiti, ker se lahko okužba s HIV z materinim mlekom prenese na otroka.
English: Therefore, patients should remain under close clinical observation by physicians experienced in the treatment of these associated HIV diseases.
Slovenian: Bolniki morajo torej ostati pod skrbnim kliničnim nadzorom zdravnikov z izkušnjami pri zdravljenju na okužbo z virusom HIV vezanih bolezni.
English: Data show that abacavir, lamivudine and zidovudine penetrate the central nervous system (CNS) and reach the cerebrospinal fluid (CSF).
Slovenian: Podatki kažejo, da abakavir, lamivudin in zidovudin prehajajo v centralni živčni sistem (CŽS) in dosežejo cerebrospinalno tekočino (CST).
English: The most common symptoms are:
Slovenian: Najpogostejši simptomi so:
English: The overall selection frequency for M184V or M184I was high (85 %), and selection of L74V, K65R and Y115F was not observed (see Table).
Slovenian: Celotna pogostnost selekcije M184V ali M184I je bila visoka (85 %), selekcije L74V, K65R in Y115F pa niso bile opažene (glejte tabelo).
English: People with advanced HIV infection (AIDS) have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Slovenian: Bolniki z napredovalo okužbo s HIV (aidsom) imajo oslabel imunski sistem, zato imajo večjo verjetnost za nastanek resnih okužb (oportunističnih okužb).
English: Zidovudine AUC ↑80% (UGT inhibition) ANTIHISTAMINES (HISTAMINE H2 RECEPTOR ANTAGONISTS) Ranitidine/Abacavir
Slovenian: zidovudin AUC ↑80% (zavrtje UGT) ANTIHISTAMINIKI (ANTAGONISTI HISTAMINSKIH RECEPTORJEV H2) ranitidin/abakavir
English: Similarly, the presence of TAMs gives rise to resistance to ZDV.
Slovenian: Podobno tudi prisotnost mutacij timidinskih analogov povzroči odpornost proti ZDV.
English: • if you have severe kidney problems
Slovenian: • če imate hude težave z ledvicami .
English: Lactic acidosis is more likely to develop in people who have liver disease, or in obese (very overweight) people, especially women.
Slovenian: Nastanek laktacidoze je verjetnejši pri osebah, ki imajo bolezen jeter ali so debele (zelo pretežke), zlasti pri ženskah.
English: If you forget to take a dose, take it as soon as you remember.
Slovenian: Če ste pozabili vzeti zdravilo Trizivir Če pozabite vzeti odmerek zdravila, ga vzemite, kakor hitro se spomnite.
English: It is important to take Trizivir regularly, because if you take it at irregular intervals it may not continue to work against the HIV infection, and you may be more likely to have a hypersensitivity reaction.
Slovenian: Zdravilo Trizivir morate jemati redno: če ga jemljete v nerednih presledkih, lahko ne bo več delovalo proti okužbam s HIV in obstaja večja verjetnost za preobčutljivostno reakcijo.
English: (Inhibition of alcohol dehydrogenase)
Slovenian: (zavrtje alhoholne dehidrogenaze)
English: An effect of abacavir is observed on zidovudine (Cmax reduced with 20 %) and on lamivudine (Cmax reduced with 35 %).
Slovenian: Opazili so vpliv abakavirja na zidovudin (Cmax se je zmanjšala za 20 %) in na lamivudin (Cmax se je zmanjšala za 35 %).
English: Your doctor should monitor for signs of lipoatrophy.
Slovenian: Zdravnik mora spremljalti znake lipoatrofije.
English: • aches and pains (especially in the hip, knee or shoulder)
Slovenian: • blažje in močnejše bolečine (zlasti v kolku, kolenu ali rami),
English: During your treatment, your doctor will monitor you for signs of lactic acidosis.
Slovenian: Med zdravljenjem vas bo zdravnik nadziral glede znakov laktacidoze.
English: Number of Subjects Number of Virological Failures Number of On-Therapy Genotypes K65R L74V Y115F M184V/I TAMs1 1.
Slovenian: Število oseb Število virusnih neodzivov Število genotipov med zdravljenjem K65R L74V Y115F M184V/I TAMs1 1.
English: Tell your doctor if you have heart problems, if you smoke, or have other illnesses that may increase your risk of heart disease such as high blood pressure, or diabetes.
Slovenian: Če imate težave s srcem, kadite ali bolehate za boleznijo, ki povečuje tveganje za bolezni srca, kot je zvišan krvni tlak in sladkorna bolezen, to povejte svojemu zdravniku.
English: Common: rash (without systemic symptoms) Very rare: erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis
Slovenian: Pogosti: izpuščaj (brez sistemskih simptomov) Zelo redki: multiformni eritem, Stevens-Johnsonov sindrom in toksična epidermalna nekroliza
English: If concomitant therapy with Trizivir and any of these medicinal products is necessary then extra care should be taken in monitoring renal function and haematological parameters and, if required, the dosage of one or more agents should be reduced.
Slovenian: Če je sočasno zdravljenje z zdravilom Trizivir in katerim od teh zdravil potrebno, je treba posebej paziti na spremljanje delovanja ledvic in hematoloških parametrov in v kolikor je potrebno, je treba odmerke enega ali več zdravil zmanjšati.
English: Since lamivudine is dialysable, continuous haemodialysis could be used in the treatment of overdose, although this has not been studied.
Slovenian: Ker se lamivudin dializira, bi se za odpravljanje posledic zaužitja prevelikega odmerka lahko poslužili kontinuirane hemodialize, čeprav tega niso preučevali.
English: Plasma protein binding studies in vitro indicate that abacavir binds only low to moderately (~ 49 %) to human plasma proteins at therapeutic concentrations.
Slovenian: Študije vezave na plazemske proteine in vitro kažejo, da se abakavir pri terapevtskih koncentracijah le malo do zmerno (~ 49 %) veže na humane plazemske proteine.
English: Glaxo Operations UK Ltd (trading as Glaxo Wellcome Operations), Priory Street, Ware, Hertfordshire, SG 12 0DJ, United Kingdom.
Slovenian: Glaxo Operations UK Ltd (trži Glaxo Wellcome Operations), Priory Street, Ware, Hertfordshire, SG12 0DJ, Velika Britanija ali
English: Treatment with zidovudine has been associated with loss of subcutaneous fat, which has been linked to mitochondrial toxicity.
Slovenian: Zdravljenje z zidovudinom je povezano z izgubo podkožnega maščevja, ki ga povezujejo s toksičnostjo za mitohondrije.
English: IMPORTANT - ALERT CARD TRIZIVIR (abacavir sulfate / lamivudine / zidovudine) Tablets Carry this card with you at all times
Slovenian: POMEMBNO - OPOZORILNA KARTICA TRIZIVIR (abakavirjev sulfat / lamivudin / zidovudin) tablete To kartico imejte vedno pri sebi!
English: No clinical data are available in patients with moderate or severe hepatic impairment, therefore the use of Trizivir is not recommended unless judged necessary.
Slovenian: Pri bolnikih z zmerno ali hudo jetrno okvaro ni kliničnih podatkov, zato uporaba zdravila Trizivir ni priporočljiva, razen če je nujno potrebna.
English: • a failure of the bone marrow to produce new red blood cells (pure red cell aplasia)
Slovenian: • nezmožnost kostnega mozga za tvorbo novih rdečih krvnih celic (čista aplazija rdečih celic).
English: Studies in animals showed that neither abacavir nor lamivudine nor zidovudine had any effect on fertility (see section 5.3).
Slovenian: V študijah na živalih niso ne za abakavir, ne za lamivudin, niti za zidovudin ugotovili, da bi kakorkoli vplivali na plodnost (glejte poglavje 5.3).
English: Abacavir is associated with a risk for hypersensitivity reactions (HSR) (see section4.8) characterised by fever and/or rash with other symptoms indicating multi-organ involvement.
Slovenian: Abakavir je povezan s tveganjem za preobčutljivostne reakcije (HSR) (glejte poglavje 4.8), za katere sta značilna povišana telesna temperatura in/ali izpuščaj, skupaj z drugimi simptomi, ki nakazujejo prizadetost več organov.
English: Thymidine analogue mutations (TAMs) which are selected by zidovudine (ZDV) were also found (8%).
Slovenian: Ugotovljene so bile tudi mutacije timidinskih analogov (TAMs; “Thymidine analogue mutations”), ki so bile posledice selekcije z zidovudinom (ZDV) (8 %).
English: Table 1: Adverse reactions reported with the individual components of Trizivir
Slovenian: Tabela 1: Neželeni učinki o katerih so poročali po jemanju posameznih učinkovin zdravila Trizivir
English: The EU RMP of the abacavir (ABC) containing products (Ziagen, Kivexa and Trizivir) includes the following risk minimisation plan in relation to abacavir hypersensitivitiy reaction (HSR), which is an important identified risk:
Slovenian: EU RMP za zdravila z abakavirjem (ABC) (Ziagen, Kivexa in Trizivir) vključuje naslednji načrt za zmanjšanje tveganja v zvezi s preobčutljivostnimi reakcijami na abakavir, ki so pomembno ugotovljeno tveganje: Skrbi glede varnosti
English: • increased levels of lactic acid in the blood, which on rare occasions can lead to lactic acidosis
Slovenian: • porast koncentracije mlečne kisline v krvi; to lahko v redkih primerih povzroči laktacidozo.
English: Food decreased the rate of absorption of Trizivir (slight decrease Cmax (mean 18 - 32 %) and increase tmax (approximately 1 hour), but not the extent of absorption (AUC0-∞).
Slovenian: Trizivir (rahlo zmanjšana Cmax (srednja vrednost 18 - 32 %) in povečan tmax (približno 1 ura)), vendar pa na obseg absorpcije (AUC0-∞) ni vplivala.
English: The remaining arms were continued in a blinded fashion.
Slovenian: Preostali dve skupini sta nadaljevali s slepim zdravljenjem.
English: The presence of M184V with Y115F gives rise to cross-resistance between abacavir and lamivudine.
Slovenian: Prisotnost M184V z Y115F povzroči navzkrižno odpornost med abakavirjem in lamivudinom.
English: • clarithromycin, an antibiotic If you are taking clarithromycin, take your dose at least 2 hours before or after you take your Trizivir.
Slovenian: Če jemljete klaritromicin, ga vzemite vsaj 2 uri prej ali potem, ko vzamete zdravilo Trizivir.
English: Patients should be regularly assessed for signs of lipoatrophy during therapy with zidovudine and zidovudine-containing products (Combivir and Trizivir).
Slovenian: Bolnike je treba med zdravljenjem z zidovudinom in zdravili, ki vsebujejo zidovudin (Combivir in Trizivir) redno ocenjevati glede znakov lipoatrofije.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterium infections, and Pneumocystis jirovecii pneumonia.
Slovenian: Ustrezni primeri so citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami in s Pneumocystis jirovecii povzročena pljučnica.
English: Trizivir is used to treat HIV (human immunodeficiency virus) infection in adults.
Slovenian: Zdravilo Trizivir se uporablja za zdravljenje okužbe z virusom HIV (humane imunske pomanjkljivosti) pri odraslih.
English: Phenytoin AUC ↑↓
Slovenian: AUC fenitoina ↑↓
English: MARKETING AUTHORISATION NUMBER(S) EU/1/00/156/003
Slovenian: ŠTEVILKA(E) DOVOLJENJA(DOVOLJENJ) ZA PROMET EU/1/00/156/003
English: Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2).
Slovenian: Izdaja zdravila je le pod omejenimi pogoji in na recept (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
English: IMPORTANT: for information on abacavir hypersensitivity see the information below, under the Description of selected adverse reactions
Slovenian: POMEMBNO: glede podatkov o preobčutljivosti na abakavir, glejte informacije spodaj v razdelku »Opis izbranih neželenih učinkov-Preobčutljivost na abakavir«
English: There are no additional precautions or warnings relevant to the combination Trizivir.
Slovenian: Dodatnih previdnostnih ukrepov in opozoril, ki bi se nanašala na kombinirano zdravilo Trizivir ni.
English: Occasionally, hypersensitivity reactions have developed in people who start taking abacavir containing products again, but who had only one symptom on the Alert Card before they stopped taking it.
Slovenian: Občasno so se preobčutljivostne reakcije pojavile pri ljudeh, ki so znova začeli jemati zdravila, ki vsebujejo abakavir in so imeli prej, preden so ga prenehali jemati, le enega od simptomov z opozorilne kartice.
English: Zidovudine AUC ↓12%
Slovenian: zidovudin AUC ↓12%
English: Physicians should refer to the individual summary of product characteristics of these medicinal products.
Slovenian: Zdravniki morajo upoštevati posamezne Povzetke glavnih značilnosti zdravila za vsa tri zdravila.
English: Very rarely cases of erythema multiforme, Stevens-Johnson syndrome or toxic epidermal necrolysis have been reported where abacavir hypersensitivity could not be ruled out.
Slovenian: Poročali so o zelo redkih primerih multiformnega eritema, StevensJohnsonovega sindroma ali toksične epidermalne nekrolize, ko preobčutljivosti na abakavir ni bilo mogoče izključiti.
English: Trizivir tablets are available in opaque white PCTFE/PVC-Al blister packs or child-resistant foil PVC/PCTFE/PVC-Al/Paper blister packs containing 60 tablets, or child resistant HDPE bottles containing 60 tablets.
Slovenian: Tablete zdravila Trizivir so na voljo v neprosojnih PCTFE /PVC-Al pretisnih omotih ali v za otroke varnih PVC/PCTFE/PVC-Al/papir pretisnih omotih s 60 tabletami ali v za otroke varnih plastenkah iz HDPE, ki vsebujejo 60 tablet.
English: ABC HSR Education Programme has been in place since the first approval of ABC as the single active preparation, ZIAGEN (USA December 1998, EU July 1999).
Slovenian: ABC kot zdravila z eno učinkovino, ZIAGEN (ZDA, december 1998, EU julij 1999).
English: Clinical studies have shown that there are no clinically significant interactions between abacavir, lamivudine and zidovudine.
Slovenian: S kliničnimi študijami je bilo dokazano, da med abakavirjem, lamivudinom in zidovudinom ni klinično pomembnih interakcij.
English: Pains in the joints or muscles, swelling of the neck, shortness of breath, sore throat, cough, occasional headaches, inflammation of the eye (conjunctivitis), mouth ulcers, low blood pressure, tingling or numbness of the hands or feet.
Slovenian: Bolečine v sklepih ali mišicah, oteklost vratu, kratka sapa, vnetje žrela, kašelj, občasen glavobol, vnetje očesne veznice (konjunktivitis), razjede v ustih, nizek krvni tlak, mravljinčenje ali omrtvelost rok ali nog.
English: • presence of skin rash; OR
Slovenian: • se pojavi izpuščaj na koži; ALI
English: Therapy should be prescribed by a physician experienced in the management of HIV infection.
Slovenian: Odmerjanje Zdravljenje mora predpisati zdravnik z izkušnjami pri zdravljenju okužb z virusom HIV.
English: Recommendation concerning coadministration
Slovenian: Priporočilo glede sočasne uporabe
English: If ABC hypersensitivity cannot be ruled out, ABC should be permanently discontinued, regardless of the results of HLA-B*5701 screening.
Slovenian: Če preobčutljivosti na ABC ni mogoče izključiti, je treba ABC trajno prenehati uporabljati, ne glede na rezultate presejanja za HLA-B*5701.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse reactions.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki se zdravijo s kombiniranim protiretrovirusnim zdravljenjem, obstaja večje tveganje za resne in potencialno smrtne neželene učinke povezane z jetri.
English: • loss of appetite, weight loss
Slovenian: • izguba apetita, izguba telesne mase,
English: If Trizivir is discontinued in patients co-infected with hepatitis B virus, periodic monitoring of both liver function tests and markers of HBV replication is recommended, as withdrawal of lamivudine may result in an acute exacerbation of hepatitis (see Zeffix SmPC).
Slovenian: Če pri bolnikih, ki so sočasno okuženi z virusom hepatitisa B, zdravilo Trizivir ukinemo, je potrebno periodično spremljati tako teste jetrne funkcije kot označevalce replikacije virusa HBV, saj lahko ukinitev lamivudina vodi v akutno poslabšanje hepatitisa (glejte SmPC Zeffix).
English: Dose reduction or cessation of therapy may become necessary (see section 4.4).
Slovenian: Verjetno bo potrebno zmanjšati odmerke ali prekiniti zdravljenje (glejte poglavje 4.4).
English: IMPORTANT - Hypersensitivity reactions
Slovenian: POMEMBNO - Preobčutljivostne reakcije
English: A large amount of data on pregnant women taking lamivudine or zidovudine indicate no malformative toxicity (more than 3000 outcomes from first trimester exposure each, of which over 2000 outcomes involved exposure to both lamivudine and zidovudine).
Slovenian: Obsežni podatki o nosečnicah, ki so jemale lamivudin ali zidovudin, niso pokazali malformacijske toksičnosti (za vsakega več kot 3000 izidov po izpostavljenosti v prvem trimesečju, od tega več kot 2000 izidov po izpostavljenosti obema, lamivudinu in zidovudinu).
English: In a pharmacokinetic study in HIV-1 infected patients, the steady state pharmacokinetic parameters of abacavir, lamivudine and zidovudine were similar when either Trizivir alone or the combination tablet lamivudine/zidovudine and abacavir in combination were administered, and also similar to the values obtained in the bioequivalence study of Trizivir in healthy volunteers.
Slovenian: V farmakokinetični študiji, ki je vključevala z virusom HIV-1 okužene bolnike, so bili farmakokinetični parametri v stanju ravnotežja za abakavir, lamivudin in zidovudin podobni tako po jemanju zdravila Trizivir samega kot po jemanju kombinirane tablete lamivudin/zidovudin v kombinaciji z abakavirjem, in prav tako podobni vrednostim, ki so bile pridobljene v bioekvivalenčni študiji z zdravilom Trizivir pri zdravih prostovoljcih.
English: The other ingredients are microcrystalline cellulose, sodium starch glycollate and magnesium stearate in the core of the tablet.
Slovenian: Ostale sestavine so mikrokristalna celuloza, natrijev karboksimetilškrob in magnezijev stearat v jedru tablete.
English: In patients with early HIV disease haematological adverse reactions are infrequent.
Slovenian: Pri bolnikih v zgodnjem obdobju HIV bolezni, so neželeni hematološki učinki redki.
English: • dapsone, to prevent pneumonia and treat skin infections
Slovenian: • dapson za preprečevanje pljučnice in zdravljenje okužb kože,
English: If you have any further questions ask your doctor or pharmacist.
Slovenian: - Če imate dodatna vprašanja, se posvetujte z zdravnikom ali farmacevtom.
English: Early symptoms (symptomatic hyperlactatemia) include benign digestive symptoms (nausea, vomiting and abdominal pain), non-specific malaise, loss of appetite, weight loss, respiratory symptoms (rapid and/or deep breathing) or neurological symptoms (including motor weakness).
Slovenian: Zgodnji simptomi (simptomatska hiperlaktatemija) vključujejo blažje prebavne simptome (navzeo, bruhanje in abdominalno bolečino), nespecifično splošno slabo počutje, izgubo apetita, hujšanje, respiratorne simptome (hitro in/ali globoko dihanje) ali nevrološke simptome (vključno z motorično oslabelostjo).
English: • interferon, to treat viral infections
Slovenian: • interferon za zdravljenje virusnih okužb,
English: The antiviral activity of abacavir in cell culture was not antagonized when combined with the nucleoside reverse transcriptase inhibitors (NRTIs) didanosine, emtricitabine, stavudine or tenofovir, the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, or the protease inhibitor (PI) amprenavir.
Slovenian: Protivirusno delovanje abakavirja v celični kulturi ni bilo antagonistično v kombinaciji z nukleozidnimi zaviralci reverzne transkriptaze (NRTI) didanozinom, emtricitabinom, stavudinom ali tenofovirjem, nenukleozidnim zaviralcem reverzne transkriptaze (NNRTI) nevirapinom ali zaviralcem proteaz (PI) amprenavirjem.