FrancophonIA/ELRC3.0 huggingface dataset:
English: Caution should be exercised in administering clarithromycin with Lopinavir/Ritonavir Mylan to patients with impaired hepatic or renal function.
Danish: Der bør udvises forsigtighed ved administration af clarithromycin med Lopinavir/Ritonavir Mylan til patienter med nedsat lever- eller nyrefunktion.
English: Concentrations may be reduced due to increased glucuronidation by lopinavir/ritonavir.
Danish: Koncentrationerne kan være nedsat på grund af øget glucuronidering af lopinavir/ritonavir.
English: Co-administration of Lopinavir/Ritonavir Mylan with rifampicin is not recommended as the decrease in lopinavir concentrations may in turn significantly decrease the lopinavir therapeutic effect.
Danish: Samtidig administration af Lopinavir/Ritonavir Mylan med rifampicin anbefales ikke, da faldet i lopinavir-koncentrationen igen kan nedsætte den terapeutiske effekt af lopinavir betydeligt.
English: Particular caution should be used when prescribing sildenafil or tadalafil for the treatment of erectile dysfunction in patients receiving lopinavir/ritonavir.
Danish: PDE-5-hæmmereDer bør udvises særlig forsigtighed, når sildenafil eller tadalafil ordineres til behandling af erektil dysfunktion hos patienter, som får lopinavir/ritonavir.
English: In an open-label pharmacokinetic study, 12 HIV-infected pregnant women who were less than 20 weeks of gestation and on combination antiretroviral therapy initially received lopinavir/ritonavir 400 mg/100 mg (two 200/50 mg tablets) twice daily up to a gestational age of 30 weeks.
Danish: I et åbent farmakokinetisk studie fik 12 hiv-inficerede gravide kvinder, som var under 20. gestationsuge og i antiretroviral kombinationsbehandling, først lopinavir/ritonavir 400 mg/100 mg (to 200/50 mg tabletter) to gange dagligt frem til en gestationsalder på 30 uger.
English: If you are taking lopinavir/ritonavir twice a day
Danish: Hvis du tager lopinavir/ritonavir to gange daglig
English: Lopinavir/ritonavir 800/200 mg QD was administered with ombitasvir/paritaprevir/ritonavir with or without dasabuvir.
Danish: Lopinavir/ritonavir 800/200 mg en gang daglig blev administreret med ombitasvir/paritaprevir/ritonavir med eller uden dasabuvir.
English: Since lopinavir/ritonavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of the active substance.
Danish: Da lopinavir/ritonavir er stærkt proteinbundet, vil dialyse ikke i væsentligt omfang kunne bidrage til udskillelse af stoffet.
English: The clinical relevance of these preclinical data is unknown, however, the potential cardiac effects of this product in humans cannot be ruled out (see also sections 4.4 and 4.8).
Danish: Den kliniske relevans af disse prækliniske data er ukendt, men det kan ikke udelukkes at dette lægemiddel har potentielle kardiale virkninger (se pkt.
English: Increased risk of tumor lysis syndrome at the dose initiation and during the ramp-up phase (see section 4.5).
Danish: Øget risiko for tumorlysesyndrom ved dosisinitiering og under dosistitreringsfasen (se pkt.
English: You must not take Lopinavir/Ritonavir Mylan with colchicine if you have kidney and/or liver problems (see also ‘Do not take Lopinavir/Ritonavir Mylan' above);
Danish: Du må ikke tage Lopinavir/Ritonavir Mylan sammen med colchicin, hvis du har problemer med nyre- og/eller lever (se også punktet ”Tag ikke Lopinavir/Ritonavir Mylan” ovenfor);
English: Multipack: 360 (3 bottles of 120) film-coated tablets
Danish: Multipakning: 360 (3 flasker med 120) filmovertrukne tabletter
English: Cases of pancreatitis have been reported in patients receiving lopinavir/ritonavir, including those who developed hypertriglyceridaemia.
Danish: Tilfælde af pankreatitis er blevet rapporteret hos patienter i behandling med lopinavir/ritonavir, deriblandt patienter, der udviklede hypertriglyceridæmi.
English: Plasma concentrations may be increased due to P-glycoprotein inhibition by lopinavir/ritonavir.
Danish: Plasmakoncentrationerne kan være øget på grund af P-glycoproteinhæmning af lopinavir/ritonavir.
English: Potential for serious and/or lifethreatening reactions in patients with renal and/or hepatic impairment (see sections 4.4 and 4.5).
Danish: Risiko for alvorlige og/eller livstruende reaktioner hos patienter med nedsat nyre- og/eller leverfunktion (se pkt.
English: Life-threatening and fatal drug interactions have been reported in patients treated with colchicine and strong inhibitors of CYP3A like ritonavir.
Danish: Der er rapporteret om livstruende og dødelige lægemiddelinteraktioner hos patienter behandlet colchicin og potente CYP3A-hæmmere som lopinavir/ritonavir (se pkt.
English: Multiple dosing of 800/200 mg lopinavir/ritonavir once daily for 2 weeks without meal restriction (n=16) produced a mean ± SD lopinavir peak plasma concentration (Cmax) of 14.8 ± 3.5 μg/ml, occurring approximately 6 hours after administration.
Danish: Gentagen dosering af 800/200 mg lopinavir/ritonavir en gang dagligt i 2 uger uden måltidsrestriktion (n=16) gav en gennemsnitlig ± SD lopinavir peak-plasmakoncentration (Cmax) på 14,8 ± 3,5 μg/ml, som forekom cirka 6 timer efter administration.
English: weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Danish: Hvis du bemærker nogen symptomer på infektion eller andre symptomer såsom muskelsvaghed, svaghed som starter i hænder og fødder og bevæger sig op gennem kroppen, hjertebanken, rysten eller hyperaktivitet, skal du omgående kontakte din læge for at få den nødvendige behandling.
English: The choice of lopinavir/ritonavir to treat protease inhibitor experienced HIV-1 infected patients should be based on individual viral resistance testing and treatment history of patients (see sections 4.4 and 5.1).
Danish: Valget af lopinavir/ritonavir til behandling af hiv-1-patienter, der allerede er blevet behandlet med proteasehæmmere, skal baseres på test af individuel viral resistens og patientens anamnese (se pkt.
English: Uncommon Weight increased, increased appetite
Danish: Vægtstigning, øget appetit Psykiske forstyrrelser Almindelig Angst
English: HIV RNA < 400 copies/ml Mean increase from baseline in CD4+ T-cell count (cells/mm3)
Danish: hiv-RNA < 400 kopier/ml Gennemsnitlig stigning i CD4+ Tcelletælling(celler/mm3) fra baseline
English: Co-administration of ibrutinib and Lopinavir/Ritonavir Mylan may increase ibrutinib exposure which may increase the risk of toxicity including risk of tumor lysis syndrome.
Danish: Samtidig administration af ibrutinib og Lopinavir/Ritonavir Mylan kan øge ibrutinibeksponeringen, hvilket kan øge risikoen for toksicitet inklusiv risikoen for tumorlysesyndrom.
English: Abacavir, Zidovudine:
Danish: Abacavir, zidovudin:
English: Lopinavir/ritonavir is not a cure for HIV infection or AIDS.
Danish: Lopinavir/ritonavir helbreder ikke hiv-infektion eller AIDS.
English: Patients were randomised in a 1:1 ratio to receive either lopinavir/ritonavir 800/200 mg once daily (n = 333) or lopinavir/ritonavir 400/100 mg twice daily (n = 331).
Danish: Patienterne blev randomiseret i forholdet 1:1 til at få enten lopinavir/ritonavir 800/200 mg en gang dagligt (n = 333) eller lopinavir/ritonavir 400/100 mg to gange dagligt (n = 331).
English: - Multipack containing 360 (3 bottles of 120) film-coated tablets.
Danish: - Multipakning med 360 (3 flasker med 120) filmovertrukne tabletter.
English: Clinical recommendation concerning co-administration with Lopinavir/Ritonavir Mylan
Danish: Kliniske anbefalinger vedrørende samtidig administration med Lopinavir/Ritonavir Mylan
English: Lopinavir/ritonavir tablets must be swallowed whole and not chewed, broken or crushed.
Danish: Lopinavir/ritonavir tabletter skal synkes hele og ikke tygges, deles eller knuses.
English: In addition, virologic response was observed in 91% (21/23), 71% (15/21) and 33% (2/6) patients with 0 − 5, 6 − 7, and 8
Danish: Desuden blev et virologisk respons observeret hos 91 % (21/23), 71 % (15/21), og 33 % (2/6) patienter med henholdsvis 0-5, 6-7 og 8-10 mutationer af de mutationer i hiv-protease, der er nævnt ovenfor, som relaterer til nedsat følsomhed til lopinavir in vitro.
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Danish: Er du i tvivl om, hvordan du skal tage medicinen, så spørg lægen eller apotekspersonalet.
English: Lopinavir/ritonavir is contraindicated in patients with severe liver impairment (see section 4.3).
Danish: Lopinavir/ritonavir er kontraindiceret til patienter med alvorligt nedsat leverfunktion (se pkt.
English: Concomitant administration of Lopinavir/Ritonavir Mylan with colchicine in patients with renal and/or hepatic impairment is contraindicated due to a potential increase of colchicine-related serious and/or life-threatening reactions such as neuromuscular toxicity (including rhabdomyolysis) (see sections 4.3 and 4.4).
Danish: Samtidig administration af Lopinavir/Ritonavir Mylan og colchicin er kontraindiceret til patienter med nedsat nyre-og/eller leverfunktion på grund af risikoen for øgede colchicin-relaterede alvorlige og livstruende reaktioner som neuromuskulær toksicitet (inklusive rabdomyolyse) (se pkt.4.3 og 4.4).
English: Lopinavir/ritonavir medicinal product level decreased Herbal products
Danish: Nedsat koncentration af lopinavir/ritonavir Naturlægemidler
English: Undesirable effects in clinical studies and post-marketing in adult patients System organ class
Danish: Bivirkninger i kliniske studier og post-marketing for voksne Systemorganklasse Hyppighed Bivirkning Infektioner og parasitære sygdomme
English: - The active substances are lopinavir and ritonavir - The other ingredients are sorbitan laurate, colloidal anhydrous silica, copovidone, sodium stearyl fumarate, hypromellose, titanium dioxide (E171), macrogol, hydroxypropylcellulose, talc, polysorbate
Danish: - Øvrige indholdsstoffer: Sorbitanlaurat, silica, kolloid vandfri, copovidon, natriumstearylfumarat, hypromellose, titandioxid (E171), macrogol, hydroxypropylcellulose, talcum, polysorbat 80.
English: Across studies, administration of lopinavir/ritonavir 400/100 mg twice daily yields mean steady-state lopinavir plasma concentrations 15 to 20-fold higher than those of ritonavir in HIV-infected patients.
Danish: I forskellige afprøvninger af hiv-smittede patienter ses det, at lopinavir/ritonavir 400/100 mg to gange dagligt forårsager gennemsnitlige steady-state lopinavir plasmakoncentrationer, der er 15 til 20 gange højere end ritonavir.
English: Furthermore, rare increases in PR interval have been reported during lopinavir/ritonavir therapy (see section 4.4).
Danish: Derudover er der i sjældne tilfælde blevet rapporteret forlænget PR-interval under lopinavir/ritonavir-behandling (se pkt.
English: Simeprevir 200 mg daily (ritonavir 100 mg BID)
Danish: Simeprevir 200 mg daglig (ritonavir 100 mg 2 gange daglig)
English: Concomitant use of Lopinavir/Ritonavir Mylan with rilpivirine causes an increase in the plasma concentrations of rilpivirine, but no dose adjustment is required.
Danish: Samtidig administration af Lopinavir/Ritonavir Mylan og rilpivirin øger rilpivirin-plasmakoncentrationen, men dosisjustering er ikke nødvendig.
English: − You must not take lopinavir/ritonavir with sildenafil used to treat pulmonary arterial hypertension (high blood pressure in the pulmonary artery) (see also Do not take Lopinavir/Ritonavir Mylan section above).
Danish: Du må ikke tage lopinavir/ritonavir med sildenafil for at behandle unormalt forhøjet blodtryk i lungernes blodkar (pulmonal arteriel hypertension) (se også punktet Tag ikke Lopinavir/Ritonavir Mylan ovenfor).
English: Bedaquiline: AUC: ↑ 22% Cmax: ↔
Danish: Bedaquilin: AUC: ↑ 22% Cmax: ↔
English: - Lopinavir/Ritonavir Mylan contains the active substances lopinavir and ritonavir.
Danish: Lopinavir/ritonavir indeholder de aktive stoffer lopinavir og ritonavir.
English: Concentrations may be decreased due to CYP3A induction by carbamazepine and phenobarbital.
Danish: Koncentrationerne kan være nedsat på grund af CYP3A-induktion af carbamazepin og phenobarbital.
English: Due to BCRP (breast cancer resistance protein/ABCG2) and acute P-gp inhibition by lopinavir/ritonavir
Danish: På grund lopinavir/ritonavirs hæmning af BCRP (Brystcancerresistensprotein/ABCG2) og P-gp
English: * weight based dosing recommendations are based on limited data If more convenient for patients, the lopinavir/ritonavir 200/50 mg tablets may also be considered alone or in combination with the lopinavir/ritonavir 100/25 mg tablet to achieve the recommended dose.
Danish: Hvis det er mere bekvemt for patienterne, kan lopinavir/ritonavir 200/50 mg tabletter også overvejes alene eller i kombination med lopinavir/ritonavir 100/25 mg tabletter for at opnå den anbefalede dosis.
English: When co-administered with Lopinavir/Ritonavir Mylan, sildenafil doses must not exceed 25 mg in 48 hours and tadalafil doses must not exceed 10 mg every 72 hours.
Danish: Sildenafildosis bør i intet tilfælde overstige 25 mg i 48 timer, ved samtidig administration med Lopinavir/Ritonavir Mylan og tadalafil-dosis må ikke overstige 10 mg hver 72. time.
English: All patients converted to open-label lopinavir/ritonavir at the 400/100 mg twice daily dose between week 48 and week 72.
Danish: Alle patienter på dosen 400/100 mg to gange daglig skiftede til et åbent studie af lopinavir/ritonavir mellem uge 48 og uge 72.
English: Antiviral activity of lopinavir/ritonavir in patients failing protease inhibitor therapy The clinical relevance of reduced in vitro susceptibility to lopinavir has been examined by assessing the virologic response to lopinavir/ritonavir therapy, with respect to baseline viral genotype and phenotype, in 56 patients previous failing therapy with multiple protease inhibitors.
Danish: Den kliniske relevans af nedsat følsomhed for lopinavir in vitro er blevet undersøgt ved at bestemme det virologiske respons for lopinavir/ritonavir-behandling, med hensyn til viral genotype og fænotype ved baseline, hos 56 patienter, der tidligere var blevet behandlet med proteasehæmmere uden effekt.
English: Lopinavir/ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of human immunodeficiency virus (HIV-1) infected adults, adolescents and children above the age of 2 years.
Danish: Lopinavir/ritonavir er indiceret til behandling af humant immundefektvirus (hiv)-1-smittede voksne, unge og børn over 2 år i kombination med andre antiretrovirale stoffer.
English: The Lopinavir/Ritonavir Mylan dose should be titrated upward only after rifampicin has been initiated (see section 4.4).
Danish: Lopinavir/Ritonavir Mylan-dosis bør først titreres opad, når behandling med rifampicin er indledt (se pkt.
English: In contrast, similar concentrations of lopinavir/ritonavir demonstrated no repolarisation delay in the canine cardiac Purkinje fibres.
Danish: Der blev derimod ved lignende koncentrationer ikke demonstreret nogen repolariseringsforsinkelse på kaninhjerte Purkinjefibre.
English: Lovastatin and Simvastatin Lovastatin, Simvastatin: Markedly increased plasma concentrations due to CYP3A inhibition by lopinavir/ritonavir.
Danish: Lovastatin, simvastatin: Markant forøgede plasmakoncentrationer på grund af lopinavir/ritonavirs hæmning af CYP3A.
English: (Ritonavir 200 mg twice daily)
Danish: (Ritonavir 200 mg to gange daglig)
English: Rivaroxaban (Ritonavir 600 mg twice daily)
Danish: Rivaroxaban (Ritonavir 600 mg to gange daglig)
English: To date, there is limited human experience of acute overdose with lopinavir/ritonavir.
Danish: Der er begrænset erfaring med en akut overdosis af lopinavir/ritonavir i mennesker.
English: MARKETING AUTHORISATION NUMBER EU/1/15/1067/004 - 120 Film-coated tablets EU/1/15/1067/006 - 120x1 Film-coated tablets EU/1/15/1067/005 - 360 Film-coated tablets
Danish: EU/1/15/1067/004 - 120 filmovertrukne tabletter EU/1/15/1067/006 - 120x1 filmovertrukne tabletter EU/1/15/1067/005 - 360 filmovertrukne tabletter
English: They are available in blister multipacks of 120, 120x1 (4 cartons of 30 or 30x1) or 360 (12 cartons of 30) film-coated tablets and in plastic bottles (containing a desiccant, which should not be eaten) of 120 filmcoated tablets and a multipack containing 360 (3 bottles of 120) film-coated tablets.
Danish: De findes i blistermultipakninger med 120, 120x1 (4 æsker med 30 eller 30x1) eller 360 (12 æsker med 30) filmovertrukne tabletter og i plastflasker (der indeholder et tørremiddel, som ikke må spises) med 120 filmovertrukne tabletter og en multipakning, der indeholder 360 (3 flasker med 120) filmovertrukne tabletter.
English: − weight gain.
Danish: Stærkt nedsat leverfunktion.
English: The Lopinavir/Ritonavir Mylan tablets dosage should be increased to 500/125 mg twice daily when coadministered with nevirapine.
Danish: Lopinavir/Ritonavir Mylan-tabletdosis bør øges til 500/125 mg to gange daglig ved samtidig administration med nevirapin.
English: Elbasvir/grazoprevir (50/200 mg QD)
Danish: Elbasvir/grazoprevir (50/200 mg en gang dagligt)
English: The Lopinavir/Ritonavir Mylan tablets dosage should be increased to 500/125 mg twice daily when coadministered with efavirenz.
Danish: Lopinavir/Ritonavir Mylan-tabletdosis bør øges til 500/125 mg to gange daglig ved samtidig administration med efavirenz.
English: Anticonvulsants Phenytoin
Danish: Anti-konvulsive midler Phenytoin
English: Study M98-863 was a randomised, double-blind trial of 653 antiretroviral treatment naïve patients investigating lopinavir/ritonavir (400/100 mg twice daily) compared to nelfinavir (750 mg three times daily) plus stavudine and lamivudine.
Danish: Studie M98-863 var en randomiseret, dobbeltblind afprøvning af lopinavir/ritonavir (400/100 mg to gange dagligt) hos 653 antiretroviral-naive patienter sammenlignet med nelfinavir (750 mg tre gange dagligt), og alle patienter fik samtidig stavudin og lamivudin.
English: They are available in blister multipacks of 60 or 60x1 (2 cartons of 30 or 30x1) film-coated tablets and in plastic bottles (containing a desiccant, which should not be eaten) of 60 film-coated tablets.
Danish: De findes i blistermultipakninger med 60 eller 60 x 1 (2 æsker med 30 eller 30 x 1) filmovertrukne tabletter og i plastflasker (der indeholder et tørremiddel, som ikke må spises) med 60 filmovertrukne tabletter.
English: Therefore, if coadministration of delamanid with lopinavir/ritonavir is considered necessary, very frequent ECG monitoring throughout the full delamanid treatment period is recommended (see section 4.5 and refer to the delamanid SmPC).
Danish: Hvis samtidig administration af delamanid og ritonavir anses for nødvendig, anbefales derfor meget hyppig EKG-monitorering under hele behandlingen med delamanid (se pkt.
English: Paediatric populations
Danish: Pædiatrisk poulation
English: When co-administered with phenytoin, an increase of Lopinavir/Ritonavir Mylan dosage may be envisaged.
Danish: Ved samtidig administration med phenytoin, må en øgning af Lopinavir/Ritonavir Mylan-dosis overvejes.
English: Uncommon Cerebrovascular accident, convulsion, dysgeusia, ageusia, tremor
Danish: Cerebrovaskulært attak, kramper, dysgeusi, agusi, tremor
English: Saquinavir 1000 mg BID
Danish: Saquinavir 1000 mg to gange daglig
English: Ketoconazole, Itraconazole: Serum concentrations may be increased due to CYP3A inhibition by lopinavir/ritonavir.
Danish: Ketoconazol, itraconazol: Serumkoncentrationerne kan stige på grund af lopinavir/ritonavirs hæmning af CYP3A.
English: Concomitant administration with colchicine is contraindicated in patients with renal and/or hepatic impairment (see sections 4.3 and 4.5).
Danish: Samtidig administration af colchicin er kontraindiceret til patienter med nedsat nyre- og/eller leverfunktion (se pkt.
English: Therefore, lopinavir/ritonavir tablets may be taken with or without food.
Danish: Derfor kan lopinavir/ritonavir tabletter tages med eller uden mad.
English: Caution should be exercised and reduced doses should be considered when Lopinavir/Ritonavir Mylan is co-administered with rosuvastatin (see section 4.4).
Danish: Der bør udvises forsigtighed og nedsat dosis bør overvejes, når Lopinavir/Ritonavir Mylan administreres sammen med rosuvastatin (se pkt.
English: Cushing's syndrome has been reported in patients receiving ritonavir and inhaled or intranasally administered fluticasone propionate; this could also occur with other corticosteroids metabolised via the P450 3A pathway e.g. budesonide (see section 4.4 and 4.5).
Danish: Der er rapporteret om Cushings syndrom hos patienter, som fik ritonavir og inhaleret eller intranasalt fluticasonpropionat; dette kan også forekomme med andre kortikosteroider, som metaboliseres via CYP3A, f.eks. budesonid (se punkt 4.4 og 4.5).
English: Multipack: 60 (2 cartons of 30) Film-coated tablets Multipack: 60x1 (2 cartons of 30x1) Film-coated tablets
Danish: Multipakning: 60 (2 æsker med 30) filmovertrukne tabletter Multipakning: 60x1 (2 æsker med 30x1) filmovertrukne tabletter
English: Adverse reactions from clinical trials and post-marketing experience in adult and paediatric patients:
Danish: Bivirkninger fra kliniske studier og erfaring post-marketing fra voksne og pædiatriske patienter: Nedenstående hændelser er blevet identificeret som bivirkninger.
English: The use of rivaroxaban is not recommended in patients receiving concomitant treatment with Lopinavir/Ritonavir Mylan (see section 4.4).
Danish: Rivaroxaban anbefales ikke til patienter i behandling med Lopinavir/Ritonavir Mylan (se pkt.
English: Multiple dosing with 400/100 mg lopinavir/ritonavir twice daily for 2 weeks and without meal restriction produced a mean ± SD lopinavir peak plasma concentration (Cmax) of 12.3 ± 5.4 μg/ml, occurring approximately 4 hours after administration.
Danish: Flergangsdosering med 400/100 mg lopinavir/ritonavir to gange dagligt i 2 uger og uden begrænsning af fødeindtagelse forårsager en gennemsnitlig  SD lopinavir maksimal plasmakoncentration (Cmax) på 12,3  45,4 g/ml, der fremkommer cirka 4 timer efter administration.
English: Concomitant use of sildenafil prescribed for the treatment of pulmonary arterial hypertension with lopinavir/ritonavir is contraindicated (see section 4.3).
Danish: Samtidig brug af sildenafil ordineret til behandling af pulmonal arteriel hypertension og lopinavir/ritonavir er kontraindiceret (se pkt.
English: A dose adjustment of Lopinavir/Ritonavir Mylan 400 mg/400 mg (i.e.
Danish: En dosisjustering af Lopinavir/Ritonavir Mylan 400 mg/400 mg (dvs.
English: Cpredose μg /mL
Danish: Cmax Cfør dosis μg /ml
English: Concentrations may be decreased due to CYP3A induction by dexamethasone.
Danish: Koncentrationerne kan være nedsat på grund af CYP3A-induktion af dexamethason.
English: ≥ 1.2 to < 1.4
Danish:  1,2 til < 1,4
English: In the absence of human serum, the mean IC50 of lopinavir against five different HIV-1 laboratory strains was 19 nM.
Danish: Den gennemsnitlige EC50 for lopinavir mod 5 forskellige hiv-1-laboratoriestammer var 19 nM i fravær af humant serum.
English: Lopinavir/Ritonavir Mylan tablets contain lopinavir and ritonavir, both of which are inhibitors of the P450 isoform CYP3A in vitro.
Danish: Lopinavir/Ritonavir Mylan-tabletter indeholder lopinavir og ritonavir, der begge hæmmer P450 isoform CYP3A in vitro.
English: AUC: ↑ 11.86-fold Cmax: ↑ 6.31-fold C24: ↑ 20.70-fold
Danish: AUC: ↑ 11,86 gange Cmax: ↑ 6,31 gange C24: ↑ 20,70 gange
English: − calcium channel antagonists (e.g. felodipine, nifedipine, nicardipine);
Danish: calciumantagonister (f.eks. felodipin, nifedipin, nicardipin);
English: These increases of plasma concentrations of co-administered medicinal products could increase or prolong their therapeutic effect and adverse events (see sections 4.3 and
Danish: Disse stigninger i plasmakoncentrationer af lægemidler, der anvendes samtidig med lopinavir/ritonavir, kan øge eller forlænge deres terapeutiske virkninger og bivirkninger (se pkt.