FrancophonIA/ELRC3.0 huggingface dataset:
English: C SPECIFIC OBLIGATIONS TO BE FULFILLED BY THE MARKETING AUTHORISATION HOLDER
Croatian: C POSEBNE OBVEZE KOJE MORA ISPUNITI NOSITELJ
English: However, the mutagenic potential has been evaluated, and alitretinoin has tested negative in the Ames test, the in vivo mouse micronucleus assay, the chromosomal aberration test in human lymphocytes, and the CHO cell mutation test.
Croatian: Međutim, mutagenost je bila procijenjena i alitretinoin je pokazao negativne rezultate na Amesovom testu, in vivo mišjem mikronukleusnom testu, testu kromosomske aberacije u ljudskim limfocitima i testu mutacije CHO stanica.
English: Apply Panretin to your KS lesions using a clean finger.
Croatian: Nanesite Panretin na lezije Kaposijevog sarkoma čistim prstom.
English: Very common (can occur in more than 1 in 10 patients treated): Rash, scaling, irritation, redness Cracking, scabbing, crusting, draining, oozing Pain, burning, soreness
Croatian: Vrlo česte (mogu nastati u više od 1 na 10 liječenih bolesnika): osip, ljuskice, nadraženost, crvenilo ispucalost, ogrebotine, krastice, vlaženje, gnojni iscjedak bol, žarenje, osjetljivost svrbež
English: - The other ingredients are ethanol, macrogol 400, hydroxypropylcellulose, and butylhydroxytoluene.
Croatian: - Pomoćne tvari su etanol, makrogol 400, hidroksipropilceluloza i butilhidroksitoluen.
English: How to use Panretin
Croatian: Kako primjenjivati Panretin
English: Do not use after the expiry date which is stated on the end of the tube.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na donjem dijelu tube.
English: Panretin belongs to a group of medicines that are related to vitamin A and known as retinoids.
Croatian: Panretin pripada skupini lijekova koji su slični vitaminu
English: It is recommended that Panretin gel should be applied for an initial treatment period of up to 12 weeks.
Croatian: U početnom razdoblju liječenja preporučuje se primjenjivati Panretin gel u trajanju do 12 tjedana.
English: No gross malformations were observed following oral administration to rabbits of doses 12 times the human topical dose (which resulted in plasma concentrations 60 times the highest observed plasma concentration in patients with KS following topical application of the gel).
Croatian: Nisu bile opažene velike malformacije u kunića nakon primjene oralnih doza koje su bile 12 puta veće od topikalne doze u ljudi (što je rezultiralo koncentracijama u plazmi koje su bile 60 puta veće od najviše opažene koncentracije u plazmi bolesnika s Kaposijevim sarkomom nakon topikalne primjene gela).
English: With continued application of Panretin redness and irritation may increase and swelling at the site of the application may develop.
Croatian: S nastavkom primjene Panretina crvenilo i nadraženost mogu se pojačati i može nastati oticanje na mjestu primjene.
English: Gel should not be applied on or near eyes or mucosal surfaces of the body.
Croatian: Gel se ne smije primjenjivati na oči ili sluznice ili u njihovoj blizini.
English: How to store Panretin
Croatian: Kako čuvati Panretin
English: 3 = Severe
Croatian: 3 = teški
English: Skin ulcer, Serous drainage, Exfoliative dermatitis (flaking, peeling, desquamation, exfoliation), Skin discoloration (brown discoloration, surrounding hyperpigmentation, paler), Dry skin
Croatian: kožni ulkus, serozna drenaža, eksfolijativni dermatitis (perutanje, ljuštenje, deskvamacija, eksfolijacija), diskoloracija kože (smeđa diskoloracija, okolna hiperpigmentacija, bljeđa koža), suha koža celulitis, vezikulobulozni osip, makulopapularni osip, alergijska reakcija
English: Uncommon (can occur in less than 1 in 100 but in more than 1 in 1000 patients treated): Infection
Croatian: Manje česte (mogu nastati u manje od 1 na 100 ali u više od 1 na 1000 liječenih bolesnika): infekcija alergijska reakcija otečene limfne žlijezde blijeda koža
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist
Croatian: U slučaju bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se svom liječniku ili ljekarniku.
English: - Women of child-bearing age must use an effective method of birth control while using Panretin, and for one month after finishing treatment.
Croatian: - Žene reproduktivne dobi (koje mogu začeti) moraju koristiti učinkovitu metodu kontrole začeća za vrijeme liječenja Panretinom i mjesec dana nakon završetka liječenja.
English: Vehicle (N=72)
Croatian: Podloga (N=72)
English: Care must be taken to avoid application of the gel to normal skin surrounding the lesions.
Croatian: Mora se izbjegavati nanošenje gela na normalnu kožu oko lezija.
English: Driving and using machines Panretin is unlikely to affect your ability to drive or use machines.
Croatian: Panretin najvjerojatnije neće utjecati na Vašu sposobnost upravljanja vozilima i rada na strojevima.
English: The range and frequency of detection of quantifiable plasma 9-cis-retinoic acid concentrations in patients with KS applying the medicinal product to up to 64 lesions were comparable to respective values in untreated patients.
Croatian: Raspon i učestalost detekcije mjerljivih koncentracija 9-cis-retinoične kiseline u plazmi bolesnika s KS pri primjeni lijeka na najviše 64 lezije bile su usporedive s vrijednostima u neliječenih bolesnika.
English: Mineral oil may be used between Panretin applications in order to help prevent excessive dryness or itching.
Croatian: Mineralna ulja mogu se nanositi između dvije primjene Panretina kako bi se pomoglo sprječavanju prekomjerne suhoće i svrbeža kože.
English: It is unlikely that the undesirable systemic side effects associated with oral retinoids will be observed with the use of Panretin gel because the range and frequency of quantifiable 9-cis-retinoic acid plasma levels concentrations after application of the medicinal product were comparable to the range and frequency of quantifiable plasma concentrations of circulating, naturally occurring 9-cis-retinoic acid in untreated individuals.
Croatian: Malo je vjerojatno da će se neželjene sistemske nuspojave povezane s oralnim retinoidima primijetiti pri primjeni gela Panretin zato što su raspon i učestalost mjerljive koncentracije 9-cis-retinoične kiseline nakon primjene ovog lijeka usporedivi s rasponom i učestalošću mjerljivih koncentracija u plazmi cirkulirajuće, fiziološki prisutne 9-cis-retinoične kiseline u neliječenih osoba.
English: AIDS-related Kaposi's sarcoma is infrequent in women.
Croatian: Kaposijev sarkom povezan s AIDS-om nije čest u žena.
English: Three doses of alitretinoin (0.01%, 0.05%, or 0.5%) in a topical gel formulation were given to rats in a 28-day dermal toxicology study.
Croatian: U 28-dnevnom kožnom toksikološkom ispitivanju u štakora primijenjene su tri doze alitretinoina (0,01%, 0,05% ili 0,5%) u obliku gela za topikalnu primjenu.
English: Alitretinoin was studied for genotoxic potential using the Ames test, the in vivo mouse micronucleus assay, the chromosomal aberration test in human lymphocytes, and the CHO cell mutation test.
Croatian: Genotoksični potencijal alitretinoina bio je ispitan pomoću Amesovog testa, in vivo mišjeg mikronukleusnog testa, testa kromosomske aberacije u ljudskim limfocitima i testa mutacije CHO stanica.
English: Panretin gel is supplied in a multi-use 60 g epoxy-lined aluminium tube.
Croatian: Panretin gel se isporučuje u aluminijskoj tubi za višekratnu primjenu od 60 g s epoksi premazom.
English: Dermal toxicity may become treatment-limiting, with intense erythema, oedema, and vesiculation.
Croatian: Kožna toksičnost može ograničiti liječenje pri izraženom eritemu, edemu i nastanku vezikula.
English: Haemorrhage (bleeding at or around lesions), Oedema (oedema, swelling, inflammation), Peripheral oedema
Croatian: Krvožilni poremećaji hemoragija (krvarenje u ili oko lezije), edem (edem, oticanje, upala), periferni edem flebitis, krvožilni poremećaj
English: Alitretinoin was shown to have a weak potential to be a photo-irritant based on histidine and photoprotein binding.
Croatian: Pokazano je da je fotoiritacijski potencijal, koji se osniva na vezanju alitretinoina za histidin i fotoprotein, slab.
English: Vehicle N=72
Croatian: Podloga N=72
English: - Mineral oil may be used between Panretin applications in order to help prevent excessive dryness or itching.
Croatian: - Između dvije primjene Panretina mogu se stavljati mineralna ulja kako bi se spriječila pretjerana suhoća ili svrbež.
English: Not for application to the eyes or mucous membranes.
Croatian: Ne smije se nanositi na oči i sluznice.
English: The use of other topical products on Panretin treated KS lesions should be avoided.
Croatian: Potrebno je izbjegavati primjenu drugih topikalnih pripravaka na lezije KS liječene Panretinom.
English: - Do not apply the gel to healthy skin around a KS lesion.
Croatian: - Nemojte nanositi gel na zdravu kožu oko lezije Kaposijevog sarkoma.
English: In rabbits, alitretinoin was shown to be teratogenic at a dose which resulted in plasma concentrations about 60 times the highest observed plasma concentration in male patients with KS following topical application of the gel.
Croatian: U kunića se pokazalo da je alitretinoin teratogen u dozi pri kojoj su postignute oko 60 puta veće koncentracije u plazmi u odnosu na najveće opažene koncentracije u plazmi muških ispitanika s KS nakon topikalne primjene gela.
English: This dose in rabbits resulted in plasma concentrations more than 60 times the highest observed plasma concentration in patients with KS following topical application of Panretin gel.
Croatian: Pri takvoj dozi u kunića postižu se više od 60 puta veće koncentracije u plazmi u odnosu na najveće postignute koncentracije u plazmi bolesnika s KS nakon topikalne primjene Panretin gela.
English: Skin disorder (cracking, scab, crusting, excoriation, drainage, oozing), Rash (erythema, redness, scaling, irritation, dermatitis), Pruritus (itching, pruritus)
Croatian: Poremećaji kože i potkožnog tkiva kožni poremećaj (ispucalost, hrapavost, kraste, ogrebotine, vlaženje, gnojni iscjedak), osip (eritem, crvenilo, ljuskanje, nadraženost, dermatitis), pruritus (svrbež, pruritus)
English: The patient response rate was evaluated using the AIDS Clinical Trials Group (ACTG) criteria for lesion response in KS. Study 1 included an open-label phase, in which patients themselves elected to enroll.
Croatian: Stopa odgovora bolesnika bila je procijenjena pomoću kriterija Skupine za klinička ispitivanja AIDS-a (ACTG) za odgovor lezija KS.
English: Common (can occur in less than 1 in 10 but in more than 1 in 100 patients treated): Flaking, peeling, dry skin
Croatian: Česte (mogu nastati u manje od 1 na 10 ali u više od 1 na 100 liječenih bolesnika): perutanje, ljuštenje, suha koža oticanje, upala bockanje, trnci krvarenje promjena boje kože rana na koži
English: Treatment frequency for that lesion should be reduced or suspended.
Croatian: Potrebno je smanjiti učestalost ili prekinuti liječenje takve lezije.
English: In this latter group, the range and frequency of detection of quantifiable 9-cis-retinoic acid plasma concentrations in patients with KS after application of the medicinal product were comparable to the range and frequency of detection of quantifiable plasma concentrations of circulating, naturally-occurring 9-cis-retinoic acid in untreated individuals.
Croatian: U ovoj zadnjoj skupini, raspon i učestalost mjerljivih koncentracija 9-cis-retinoične kiseline u bolesnika s KS nakon primjene ovog lijeka bili su usporedivi s rasponom i učestalošću detekcije mjerljivih fizioloških koncentracija u plazmi 9-cis-retinoične kiseline u neliječenih osoba.
English: Name and address of the manufacturer responsible for batch release
Croatian: Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet Eisai Manufacturing Limited
English: Lesions
Croatian: Lezije
English: It is supplied in a multi-use 60 g epoxy-lined aluminium tube.
Croatian: Isporučuje se u aluminijskoj tubi za višekratnu primjenu od 60 g s epoksi premazom.
English: C. SPECIFIC OBLIGATIONS TO BE FULFILLED BY THE MARKETING AUTHORISATION HOLDER
Croatian: POSEBNE OBVEZE KOJE MORA ISPUNITI NOSITELJ
English: The use of other topical products on treated KS lesions should be avoided.
Croatian: Potrebno je izbjegavati primjenu drugih topikalnih pripravaka na liječene lezije KS.
English: Vehicle (N=134)
Croatian: Podloga (N=134)
English: Vehicle N=134
Croatian: Podloga N=134
English: It is recommended that you should not eat more vitamin A in your diet than the amount suggested by your doctor.
Croatian: A hranom nego što je predložio Vaš liječnik.
English: It is recommended that daily dietary intake of vitamin A should not exceed the Recommended Dietary Intake value.
Croatian: A hranom ne bude veći od preporučenog dnevnog unosa.
English: NUMBER(S) IN THE COMMUNITY REGISTER OF MEDICINAL PRODUCTS
Croatian: 12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: A MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE
Croatian: PROIZVOĐAČ ODGOVORAN ZA PUŠTANJE SERIJE LIJEKA U PROMET
English: Paraesthesia (stinging, tingling)
Croatian: Poremećaji živčanog sustava parestezije (bockanje, trnci)
English: Pharmacokinetic studies indicate that the range and frequency of detection of quantifiable 9-cis-retinoic acid plasma concentrations in patients with KS after application of the medicinal product were comparable to the range and frequency of detection of quantifiable plasma concentrations of circulating, naturally-occurring 9-cis-retinoic acid in untreated individuals (see section 5.2).
Croatian: Farmakokinetička ispitivanja pokazuju da su raspon i učestalost detekcije mjerljivih koncentracija 9-cis-retinoične kiseline u bolesnika s KS nakon primjene ovog lijeka bili usporedivi s rasponom i učestalošću detekcije mjerljivih koncentracija u plazmi cirkulirajuće,
English: Posology
Croatian: ODOBRENJA
English: Hydroxypropylcellulose Butylhydroxytoluene
Croatian: 6.1 Popis pomoćnih tvari etanol makrogol 400 hidroksipropilceluloza butilhidroksitoluen
English: What Panretin looks like and contents of the pack Panretin is a clear yellow gel.
Croatian: Kako Panretin izgleda i sadržaj pakiranja
English: Bleeding
Croatian: Dojenje
English: This overview was last updated in November 2018.
Croatian: Ovaj pregled informacija posljednji je put ažuriran u studenome 2018.
English: Isemid (torasemide)
Croatian: Isemid (torasemid)
English: It works by increasing the loss of water and salt in the urine.
Croatian: Djeluje tako da povećava gubitak vode i soli u urinu.
English: The tablet can be given with food or directly into the mouth if the dog does not take it easily.
Croatian: Tableta se može dati s hranom ili izravno u usta ako je pas ne uzima lako.
English: It is given once daily and the starting dose depends on bodyweight.
Croatian: Daje se jednom dnevno, a početna doza ovisi o tjelesnoj težini.
English: The dose is then reduced and adjusted according the dog's response.
Croatian: Dozu zatim treba smanjiti i prilagoditi u skladu s odgovorom psa na liječenje.
English: Further information on Isemid can be found on the Agency's website: ema.europa.eu/ medicines/veterinary/EPAR/isemid.
Croatian: Više informacija o VMP-u Isemid nalazi se na internetskim stranicama Agencije: ema.europa.eu/ medicines/veterinary/EPAR/isemid.
English: Isemid must not be given at the same time as other diuretics which work in the same way as torasemide.
Croatian: Isemid se ne smije davati istodobno s drugim diureticima koji djeluju na isti način kao torasemid.
English: What is Isemid and what is it used for?
Croatian: Što je Isemid i za što se primjenjuje?
English: The usual dose is 0.13 to 0.25 mg torasemide per kg bodyweight once daily.
Croatian: Uobičajena doza je od 0,13 do 0,25 mg torasemida po kilogramu tjelesne težine jednom dnevno.
English: This medicine may also cause hypersensitivity (allergic) reactions.
Croatian: Ovaj veterinarsko-medicinski proizvod može prouzročiti preosjetljivost (alergijsku reakciju).
English: Isemid (torasemide) EMA/790616/2018
Croatian: Isemid (torasemid) EMA/15631/2019
English: The European Medicines Agency decided that Isemid's benefits are greater than its risks and it can be authorised for use in the EU.
Croatian: Europska agencija za lijekove zaključila je da koristi od VMP-a Isemid nadmašuju s njim povezane rizike te se može izdati odobrenje za njegovu primjenu u EU-u.
English: The most common side effects with Isemid (which may affect more than 1 in 10 animals) are poor function of the kidneys, alterations in blood tests measuring kidney function, haemoconcentration (increase in the concentration of red blood cells circulating in the blood), and changes in electrolyte (salt) levels (chloride, sodium, potassium, phosphorus, magnesium and calcium).
Croatian: Najčešće nuspojave VMP-a Isemid (koje se mogu pojaviti u više od 1 na 10 životinja) su slabo funkcioniranje bubrega, promjene vrijednosti krvnih pretraga kojima se mjeri bubrežna funkcija, hemokoncentracija (povećana koncentracija crvenih krvnih stanica koje cirkuliraju u krvi), kao i promjene u razinama elektrolita (soli) (klorida, natrija, kalija, fosfora, magnezija i kalcija).
English: Torasemide is a diuretic medicine.
Croatian: Torasemid je diuretik.
English: This decreases the overall blood volume, reducing the effort needed for the heart to pump blood and thereby improving its function.
Croatian: Time se smanjuje ukupni volumen krvi, a stoga i napori potrebni da bi srce pumpalo krv, što dovodi do poboljšanja njegove funkcije.
English: Other information about Isemid
Croatian: Ostale informacije o VMP-u Isemid
English: This can lead to exercise intolerance (inability to carry out physical activity), difficulty breathing and fluid retention.
Croatian: To stanje može rezultirati intolerancijom na vježbanje (nemogućnošću bavljenja fizičkom aktivnošću), otežanim disanjem i zadržavanjem tekućine.
English: The main measure of effectiveness was a reduction in scores for lung fluid and cough (both are signs of congestive heart failure) after 14 days of treatment and no worsening of difficulty in breathing or exercise intolerance scores.
Croatian: Glavna mjera učinkovitosti bilo je smanjenje vrijednosti za tekućinu u plućima i kašalj (oboje su znaci kongestivnog zatajenja srca) nakon 14 dana liječenja i izostanak pogoršanja vrijednosti za poteškoće u disanju ili intoleranciju na
English: Congestive heart failure is a condition when the heart cannot pump enough blood around the body.
Croatian: Kongestivno zatajenje srca je stanje kod kojeg srce ne može istisnuti dovoljnu količinu krvi kroz tijelo.
English: Any part-used tablets should be returned to the blister pack and then to the original carton to keep them out of the reach of children.
Croatian: Sve djelomično iskorištene tablete treba vratiti u pakiranje s blisterima i zatim u originalnu kutiju kako bi se spriječio pristup djece tabletama.
English: Isemid must not be given in cases of kidney failure, dehydration, a decrease in circulating blood volume or low blood pressure.
Croatian: Isemid se ne smije davati u slučajevima zatajenja bubrega, dehidracije, smanjenja cirkulirajućeg volumena krvi ili niskog krvnog tlaka.
English: This may be increased for up to 5 days to a maximum of 0.4 mg per kg bodyweight once daily in dogs with moderate to severe fluid retention in the lungs.
Croatian: Dozu je moguće povećati do maksimalne doze od 0,4 mg/kg tjelesne težine jednom dnevno tijekom najviše 5 dana u pasa s umjerenim do teškim zadržavanjem tekućine u plućima.
English: What are the risks associated with Isemid?
Croatian: Koji su rizici povezani s VMP-om Isemid?
English: Isemid is a veterinary medicine used to treat signs related to congestive heart failure in dogs.
Croatian: Isemid je veterinarsko-medicinski proizvod koji se upotrebljava za liječenje znakova povezanih s kongestivnim zatajenjem srca u pasa.
English: An overview of Isemid and why it is authorised in the EU
Croatian: Pregled informacija o VMP-u Isemid i zašto je odobren u EU-u
English: Why is Isemid authorised in the EU?
Croatian: Zašto je VMP Isemid odobren u EU-u?
English: In a field study involving 321 dogs with congestive heart failure, treatment with Isemid was compared with another established diuretic medicine, furosemide.
Croatian: U ispitivanju koje je obuhvatilo 321 psa s kongestivnim zatajenjem srca, liječenje VMP-om Isemid uspoređeno je s drugim uobičajenim diuretikom, furosemidom.
English: Isemid may increase urination, and lead to thirst, gut disturbances, low blood pressure and dehydration if ingested.
Croatian: Isemid može prouzročiti pojačano mokrenje, žeđ, crijevne smetnje, nizak krvni tlak i dehidraciju ako se proguta.
English: People who are hypersensitive to torasemide, sulfonamides or to any of the other ingredients in Isemid should avoid contact with the medicine.
Croatian: Osobe preosjetljive na torasemid, sulfonamide ili na bilo koji drugi sastojak trebaju izbjegavati kontakt s ovim veterinarsko-medicinskim proizvodom.
English: If the product is accidentally swallowed by a person, particularly by a child, the advice of a doctor should be sought immediately and the package leaflet or label shown to the doctor.
Croatian: Ako osoba slučajno proguta ovaj medicinskoveterinarski proizvod, posebno dijete, potrebno je odmah potražiti liječnički savjet te liječniku pokazati uputu o VMP-u ili njegovu etiketu.
English: If symptoms of allergy occur, the advice of a doctor should be sought immediately and the package leaflet or label shown to the doctor.
Croatian: Ako se pojave simptomi alergije, potrebno je odmah potražiti liječnički savjet te liječniku pokazati uputu o VMP-u ili njegovu etiketu.
English: Isemid is available as tablets and can only be obtained with a prescription.
Croatian: Isemid je dostupan u obliku tableta i izdaje se samo na veterinarski recept.
English: Isemid to be as least as effective as furosemide for the treatment of signs related to congestive heart failure with 74% of dogs in each group being successfully treated.
Croatian: Ispitivanjem je utvrđeno da je VMP Isemid barem jednako učinkovit kao furosemid u liječenju znakova povezanih s kongestivnim zatajenjem srca, s obzirom na to da je u svakoj skupini liječenje bilo uspješno za 74 % pasa.
English: What benefits of Isemid have been shown in studies?
Croatian: Koje su koristi od VMP-a Isemid utvrđene u ispitivanjima?
English: For more information about using Isemid, see the package leaflet or contact your veterinarian or pharmacist.
Croatian: Za dodatne informacije o primjeni VMP-a Isemid pogledajte uputu o VMP-u, odnosno obratite se veterinaru ili ljekarniku.
English: For the full list of side effects and restrictions of Isemid, see the package leaflet.
Croatian: Potpuni popis nuspojava i ograničenja povezanih s primjenom VMP-a Isemid potražite u uputi o lijeku.
English: How does Isemid work?
Croatian: Kako djeluje Isemid?
English: How is Isemid used?
Croatian: Kako se Isemid primjenjuje?
English: Isemid contains the active substance torasemide.
Croatian: Isemid sadržava djelatnu tvar torasemid.
English: The study showed
Croatian: vježbanje.
English: Isemid received a marketing authorisation valid throughout the EU on 09/01/2019.
Croatian: Za VMP Isemid izdano je odobrenje za stavljanje u promet koje je na snazi u Europskoj uniji od
English: If you notice any of the above symptoms:
Croatian: Ako se pojavi bilo koji od navedenih simptoma:
English: It is usually given into your arm over about 30 minutes.
Croatian: Obično se daje u ruku tijekom razdoblja od približno 30 minuta.
English: Your dose may be increased or decreased depending on how well you respond to treatment.
Croatian: Doza se može povećati ili smanjiti ovisno o tome koliko dobro odgovarate na liječenje.
English: Risk of bacterial infections
Croatian: Rizik od bakterijskih infekcija
English: Resistance in immunocompromised patients
Croatian: Rezistencija u imunokompromitiranih bolesnika
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before you are given this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego primite ovaj lijek.