FrancophonIA/ELRC3.0 huggingface dataset:
English: At baseline, median plasma HIV-1 RNA was 4.57 log10 copies/mL, median
Danish: Ved baseline var det mediane plasma hiv-RNA 4,57 log10-kopier/ml, median-CD4+ celletal var
English: White, printed with "SUSTIVA" on the body and "100 mg" on the cap. SUSTIVA 200 mg hard capsules
Danish: Hvide, præget med "SUSTIVA" på skallen og "100 mg" på hætten.
English: SUSTIVA 100 mg hard capsules can be taken by children and adolescents 3 months of age and older and weighing at least 3.5 kg who are able to swallow the capsules.
Danish: SUSTIVA 100 mg hårde kapsler må indtages af børn og unge, der er 3 måneder og ældre, der vejer mindst 3,5 kg, og som er i stand til at sluge kapslerne.
English: In healthy adult subjects, the efavirenz AUC when administered as the contents of three 200 mg hard capsules mixed with 2 teaspoons of certain food vehicles (applesauce, grape jelly, yogurt or infant formula) met bioequivalency criteria for the AUC of the intact capsule formulation administered under fasted conditions.
Danish: Hos sunde voksne undersøgelsespersoner, opfylder efavirenz AUC's kriterier for AUCbiotilgængeligheden for lægemiddel i intakte kapsler, ved indgivelse i form af tre (3) 200 mg hårde kapsler blandet med to (2) tsk.
English: one 100 mg capsule + one 50 mg capsule
Danish: en 100 mg kapsel + en 50 mg kapsel
English: ANTIHISTAMINES Cetirizine/Efavirenz (10 mg single dose/600 mg once daily)
Danish: ANTIHISTAMINER Cetirizin/efavirenz (10 mg enkeltdoser/600 mg én gang dagligt)
English: Itraconazole/Efavirenz (200 mg q12h/600 mg once daily)
Danish: Itraconazol/efavirenz (200 mg q12h/600 mg én gang dagligt)
English: Each SUSTIVA film-coated tablet contains 600 mg of the active substance efavirenz.
Danish: Hver SUSTIVA filmovertrukken tablet indeholder 600 mg af det aktive stofefavirenz.
English: (CYP3A4 induction) In a study of HIV infected intravenous drug users, co-administration of efavirenz with methadone resulted in decreased plasma levels of methadone and signs of opiate withdrawal.
Danish: I en undersøgelse med hivinficerede brugere af intravenøse stoffer resulterede samtidig administration af efavirenz og methadon i nedsat plasmakoncentration af methadon og abstinenssymptomer.
English: The median increase from baseline in CD4+ count at 48 weeks was 215 cells/mm and the median increase in CD4+ percentage was 6%.
Danish: Den mediane stigning i CD4+ tal ved uge 48 fra baseline var 215 celler/mm3, og den mediane stigning i CD4+ procent var 6%.
English: Hepatic events
Danish: Akut hepatitis
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains: efavirenz 600 mg.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver filmovertrukken tablet indeholder: Efavirenz 600 mg
English: Simeprevir/Efavirenz (150 mg once daily /600 mg once daily)
Danish: Simeprevir/efavirenz (150 mg en gang dagligt/600 mg en gang dagligt)
English: Indinavir/Efavirenz (800 mg q8h/200 mg once daily)
Danish: Indinavir/efavirenz (800 mg q8h/200 mg én gang dagligt)
English: QT Prolonging Drugs
Danish: QT-forlængende lægemidler
English: Add another small amount (approximately 2 teaspoons) of the food to the empty mixing container, stirring to make sure there is no drug residue remaining in the container, and have the child eat the full amount again.
Danish: i den tomme beholder, der er brugt til blanding, og rør om for at sikre, at der ikke er nogle medicinrester i beholderen.
English: Lopinavir/ritonavir tablets/ Efavirenz (400/100 mg twice daily/600 mg once daily) (500/125 mg twice daily/600 mg once daily)
Danish: Lopinvir/ritonavirtabletter/efavirenz (400/100 mg to gange dagligt/600 mg én gang dagligt) (500/125 mg to gange dagligt/600 mg én gang dagligt)
English: any signs of skin rash.
Danish: alle tegn på hududslæt.
English: Concomitant administration of velpatasvir/sofosbuvir/ voxilaprevir with efavirenz is not recommended (see section 4.5).
Danish: Samtidig administration af velpatasvir/sofosbuvir/voxilaprevir med efavirenz anbefales ikke (se pkt.
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 600 mg film-coated tablet efavirenz
Danish: LÆGEMIDLETS NAVN SUSTIVA 600 mg filmovertrukket tablet efavirenz
English: Concomitant use of St. John's wort is contraindicated (see section 4.3).
Danish: Samtidig brug af perikon er kontraindiceret (se pkt.
English: Gastrointestinal disorders common abdominal pain, diarrhoea, nausea, vomiting uncommon pancreatitis
Danish: Abdominale smerter, diarré, kvalme, opkastning.
English: Each hard capsule contains 57.0 mg of lactose (as monohydrate).
Danish: Hjælpestof, som behandleren skal være opmærksom på Hver hård kapsel indeholder 57,0 mg lactose (i form af monohydrat).
English: The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing this disease.
Danish: Til de mange risikofaktorer for udvikling af denne sygdom hører blandt andre: Længden af den antiretroviral kombinationsbehandling, anvendelse af kortikosteroider, alkoholforbrug, alvorligt nedsat immunforsvar samt højere Body Mass Index (BMI).
English: 6.5 Nature and content of container
Danish: 6.5 Emballagetype og pakningsstørrelser
English: INFORMATION IN BRAILLE SUSTIVA 50 mg
Danish: INFORMATION I BRAILLESKRIFT SUSTIVA 50 mg
English: Fosamprenavir/Nelfinavir/ Efavirenz
Danish: Fosamprenavir/nelfinavir/efavire nz
English: Nervous system symptoms of moderate-to-severe intensity were experienced by 19% (severe 2%) of patients compared to 9% (severe 1%) of patients receiving control regimens.
Danish: I kliniske, kontrollerede undersøgelser var de hyppigt indberettede bivirkninger bl.a. følgende: Svimmelhed, søvnløshed, døsighed, nedsat koncentrationsevne og unormal drømmeaktivitet.19% af patienterne oplevede symptomer fra nervesystemet af moderat til svær intensitet (heraf 2% af svær intensitet) sammenlignet med 9% af de patienter (heraf 1% af svær intensitet), der fik kontrolregimerne.
English: Each hard capsule contains 50 mg of efavirenz.
Danish: Hver hård kapsel indeholder 50 mg efavirenz.
English: b EFV, efavirenz; ZDV, zidovudine; 3TC, lamivudine; IDV, indinavir; NRTI, nucleoside reverse transcriptase inhibitor; NFV, nelfinavir.
Danish: EFV + IDV + NRTI´ere 157 60 (52, 68) IDV + NRTI´ere a NC = F, noncompleter = failure b EFV, efavirenz; ZDV, zidovudin; 3TC, lamivudin; IDV, indinavir; NRTI, nucleoside reverse transkriptasehæmmer; NFV, nelfinavir c
English: Because of the long half-life of efavirenz, use of adequate contraceptive measures for 12 weeks after discontinuation of efavirenz is recommended.
Danish: kontraception i 12 uger efter seponering, da efavirenz har en lang halveringstid.
English: Azithromycin/Efavirenz (600 mg single dose/400 mg once daily)
Danish: Azithromycin/efavirenz (600 mg enkeltdosis/400 mg én gang dagligt)
English: ANTICONVULSANTS Carbamazepine/Efavirenz (400 mg once daily/600 mg once daily)
Danish: ANTIKONVULSIVA Carbamazepin/efavirenz (400 mg én gang dagligt/600 mg én gang dagligt)
English: Lopinavir concentrations: ↓ 30-40% Lopinavir concentrations: similar to lopinavir/ritonavir 400/100 mg twice daily without efavirenz
Danish: Samme som for lopinavir/ritonavir 400/100 mg to gange dagligt uden efavirenz.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Danish: Ætiologien anses dog for at være multifaktoriel (omfattende anvendelse af kortikosteroider, alkoholforbrug, svær immunosuppression, højere Body Mass Index (BMI)).
English: Nelfinavir/Efavirenz (750 mg q8h/600 mg once daily)
Danish: Nelfinavir/efavirenz (750 mg q8h/600 mg én gang dagligt)
English: one 200 mg capsule + one 50 mg capsule
Danish: en 200 mg kapsel + en 50 mg kapsel
English: Efavirenz may be an inducer of CYP2C19 and CYP2C9; however, inhibition has also been observed in vitro and the net effect of co-administration with substrates of these enzymes is not clear (see section 5.2).
Danish: Der er dog også blevet observeret hæmning in vitro, og nettoeffekten ved samtidig administration af substrater for disse enzymer er ikke klarlagt (se pkt.
English: Cmin: ↓ 47% (↓ 41 to ↓ 53) (decrease in carbamazepine concentrations: CYP3A4 induction; decrease in efavirenz concentrations: CYP3A4 and CYP2B6 induction)
Danish: AUC: ↓ 36% (↓ 32 til ↓ 40) Cmax: ↓ 21% (↓ 15 til ↓ 26) Cmin: ↓ 47% (↓ 41 til ↓ 53) (fald i carbamazepinkoncentrationen: CYP3A4induktion; fald i efavirenzkoncentrationen: CYP3A4- og CYP2B6-induktion).
English: Darunavir/ritonavir/Efavirenz (300 mg twice daily*/100 mg twice daily/600 mg once daily)
Danish: Darunavir/ritonavir/efavirenz (300 mg to gange dagligt*/100 mg to gange dagligt/600 mg én gang dagligt)
English: The recommended dose of efavirenz in combination with nucleoside analogue reverse transcriptase inhibitors (NRTIs) with or without a PI (see section 4.5) is 600 mg orally, once daily.
Danish: Den anbefalede dosis af efavirenz i kombination med nukleosidanaloge reverse transkriptasehæmmere (NRTIere) med eller uden en PIer (se pkt.
English: Cmin: ↓ 8% (↑ 14 to ↓ 25) Norelgestromin (active metabolite): AUC: ↓ 64% (↓ 62 to ↓ 67)
Danish: Cmin: ↓ 8% (↑ 14 til ↓ 25) Norelgestromin (aktiv metabolit):
English: The capsules are printed with inks containing cochineal carminic acid (E120), indigo carmine (E132), and titanium dioxide (E171).
Danish: Kapslerne er præget med prægeblæk indeholdende cochenillecarminsyre (E120), indigocarmin (E132) og titandioxid (E171).
English: Nervous system symptoms usually begin during the first one or two days of therapy and generally resolve after the first 2 - 4 weeks.
Danish: Symptomer fra nervesystemet starter sædvanligvis inden for de første 1 - 2 dage af behandlingen og svinder sædvanligvis efter de første 2 - 4 uger.
English: Each SUSTIVA hard capsule contains 200 mg of the active substance efavirenz.
Danish: Hver SUSTIVA hård kapsel indeholder 200 mg af det aktive stof efavirenz.
English: Each hard capsule contains 200 mg of efavirenz.
Danish: Hver hård kapsel indeholder 200 mg efavirenz.
English: SUSTIVA 600 mg film-coated tablets efavirenz
Danish: SUSTIVA 600 mg filmovertrukne tabletter (efavirenz)
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each hard capsule contains: efavirenz 200 mg
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver hård kapsel indeholder: Efavirenz 200 mg
English: Fosamprenavir/Saquinavir/ Efavirenz
Danish: Fosamprenavir/saquinavir/efavire nz
English: Taking SUSTIVA on an empty stomach may reduce the undesirable effects.
Danish: Det kan nedsætte bivirkningerne, hvis SUSTIVA tages på tom mave.
English: bepridil (used to treat heart disease) cisapride (used to treat heartburn) ergot alkaloids (for example, ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (used to treat migraine and cluster headaches) midazolam or triazolam (used to help you sleep) pimozide, imipramine, amitriptyline or clomipramine (used to treat certain mental conditions) elbasvir or grazoprevir (used to treat hepatitis C) St. John's wort (Hypericum perforatum) (a herbal remedy used for depression and anxiety) flecainide, metoprolol (used to treat irregular heart beat) certain antibiotics (macrolides, fluoroquinolones, imidazole) triazole antifungal agents certain antimalarial treatments methadone (used to treat opiate addiction)
Danish: - sekalealkaloider (fx ergotamin, dihydroergotamin, ergonovin og methylergonovin) (mod migræne og klyngehovedpine) - midazolam eller triazolam (mod søvnløshed) - pimozid, imipramin, amitriptylin eller clomipramin (mod visse sindstilstande) - elbasvir eller grazoprevir (mod hepatitis C) - perikon (Hypericum perforatum) (et naturlægemiddel mod depression og angst) - flecainid, metoprolol (til behandling af uregelmæssig hjerterytme) - visse antibiotika (makrolider, fluoroquinoloner, imidazol) - triazol svampemidler - visse malariamidler - methadon (til behandling af opioidmisbrug).
English: CARDIOVASCULAR AGENTS Calcium Channel Blockers Diltiazem/Efavirenz (240 mg once daily/600 mg once daily)
Danish: KARDIOVASKULÆRE LÆGEMIDLER Calciumantagonister Diltiazem/efavirenz (240 mg én gang dagligt/600 mg én gang dagligt)
English: Each hard capsule contains 100 mg of efavirenz.
Danish: Hver hård kapsel indeholder 100 mg efavirenz.
English: Each SUSTIVA hard capsule contains 100 mg of the active substance efavirenz.
Danish: Hver SUSTIVA hård kapsel indeholder 100 mg af det aktive stof efavirenz.
English: You should consult your doctor if you have a rash, since some rashes may be serious; however, most cases of rash disappear without any change to your treatment with SUSTIVA.
Danish: De bør konsultere lægen, hvis De har udslæt, da nogle udslæt kan være alvorlige.
English: INFORMATION IN BRAILLE SUSTIVA 600 mg
Danish: INFORMATION I BRAILLESKRIFT SUSTIVA 600 mg
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 600 mg film-coated tablets efavirenz
Danish: LÆGEMIDLETS NAVN SUSTIVA 600 mg filmovertrukne tabletter efavirenz
English: INFORMATION IN BRAILLE SUSTIVA 200 mg
Danish: INFORMATION I BRAILLESKRIFT SUSTIVA 200 mg
English: Cmin: ↑ 12%*/** (↓16 to ↑49) (CYP3A4 induction).
Danish: AUC: ↔*/** (↓ 10 til ↑ 26) Cmax: ↔*/** (↓ 5 til ↑ 26) Cmin: ↑ 12*/** (↓ 16 til ↑ 49) (CYP3A4-induktion).
English: Bottle: EU/1/99/110/008
Danish: HDPE-beholder: EU/1/99/110/008
English: After administration of the efavirenz-food mixture, an additional small amount (approximately 2 teaspoons) of food must be added to the empty mixing container, stirred to disperse any remaining residue of the medicinal product, and administered to the patient.
Danish: Efter indgivelse af efavirenz-blandingen blandes yderligere en lille mængde føde (ca. 2 tsk.)
English: Cmin: ↑ 25% (↑ 7 to ↑ 46) b
Danish: Cmin morgen: ↑ 42% (↑ 9 til ↑ 86)b
English: Voriconazole/Efavirenz (400 mg twice daily/300 mg once daily)
Danish: Voriconazol/efavirenz (400 mg to gange dagligt/300 mg én gang dagligt)
English: Rifampicin/Efavirenz (600 mg once daily/600 mg once daily)
Danish: Rifampicin/efavirenz (600 mg én gang dagligt/600 mg én gang dagligt)
English: The capsule shell contains: gelatine, sodium laurilsulfate, yellow iron oxide (E172) and silicon dioxide.
Danish: Kapselskallen indeholder: Gelatine, natriumlaurilsulfat, gul jernoxid (E172) og siliciumdioxid.
English: Raltegravir/Efavirenz (400 mg single dose/ -)
Danish: Intergrasehæmmer af genoverførelse Raltegravir/efavirenz (400 mg enkeltdoser/ - )
English: Titanium dioxide (E171)
Danish: Hypromellose (E464) Titandioxid (E171) Macrogol 400
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 50 mg hard capsules efavirenz
Danish: LÆGEMIDLETS NAVN SUSTIVA 50 mg hårde kapsler efavirenz
English: Marketing Authorisation Holder Bristol-Myers Squibb Pharma EEIG Plaza 254
Danish: Indehaver af markedsføringstilladelse Bristol-Myers Squibb Pharma EEIG Plaza 254
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each hard capsule contains: efavirenz 50 mg.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver hård kapsel indeholder: Efavirenz 50 mg
English: INFORMATION IN BRAILLE SUSTIVA 100 mg
Danish: INFORMATION I BRAILLESKRIFT SUSTIVA 100 mg
English: Efavirenz has not been studied in controlled studies in patients with advanced HIV disease, namely with CD4 counts < 50 cells/mm3, or in PI or NNRTI experienced patients.
Danish: det vil sige CD4 tal < 50 celler/mm3 eller med PI- eller NNRTI-erfarne patienter.
English: Coadministration of sofosbuvir/velpatasvir with efavirenz is not recommended (see section 4.5).
Danish: Samtidig administration af sofosbuvir/velpatasvir med efavirenz anbefales ikke (se pkt.
English: The reproductive performance of offspring born to female rats given efavirenz was not affected.
Danish: Forplantningsevnen var ikke påvirket hos afkom af hunrotter, der havde fået efavirenz.
English: AUC: ↓ 36% (↓ 32 to ↓ 40)
Danish: AUC: ↓ 25% (↓ 16 til ↓ 32)b
English: Coadministration of glecaprevir/pibrentasvir with efavirenz is not recommended (see section 4.5).
Danish: Samtidig administration af glecaprevir/pibrentasvir med efavirenz anbefales ikke (se pkt.
English: Cmin with confidence intervals if availablea (mechanism)
Danish: Indvirkning på lægemiddelkoncentrationen, gennemsnitlig ændring (%) i AUC, Cmax, Cmin med konfidensintervaller hvis muligta (mekanisme)
English: ANTIANXIETY AGENTS Lorazepam/Efavirenz (2 mg single dose/600 mg once daily)
Danish: ANXIOLYTIKA Lorazepam/efavirenz (2 mg enkeltdoser/600 mg én gang dagligt)
English: Co-administration with elbasvir (EBR) and grazoprevir (GZR) due to the potential for significant decreases in plasma concentrations of EBR and GZR (see section 4.5).
Danish: Elbasvir og grazoprevir bør ikke anvendes sammen med efavirenz på grund af potentiel signifikant fald i plasmakoncentrationerne af elbasvir og grazoprevir (se pkt.
English: Cmin: ↓ 45% (↓ 31 to ↓ 56) Efavirenz:
Danish: Cmin: ↓ 50% (↓ 40 til ↓ 59) Efavirenz:
English: EU/1/99/110/003: bottle EU/1/99/110/004: blister
Danish: MARKEDSFØRINGSNUMMER (-NUMRE) EU/1/99/110/003: HDPE-beholder EU/1/99/110/004: Blister
English: Ritonavir:
Danish: Nelfinavir:
English: Cmax: ↓ 18% (↓ 59 to ↑ 12)
Danish: AUC: ↓ 40% (↓ 26 til ↓ 57) Cmax: ↓ 18% (↓ 59 til ↑ 12)
English: Uncommon (affects 1 to 10 users in 1,000) nervousness, forgetfulness, confusion, fitting (seizures), abnormal thoughts blurred vision a feeling of spinning or tilting (vertigo) pain in the abdomen (stomach) caused by inflammation of the pancreas allergic reaction (hypersensitivity) that may cause severe skin reactions (erythema multiforme, Stevens-Johnson syndrome) yellow skin or eyes, itching, or pain in the abdomen (stomach) caused by inflammation of the liver breast enlargement in males angry behaviour, mood being affected, seeing or hearing things that are not really there (hallucinations), mania (mental condition characterised by episodes of overactivity, elation or irritability), paranoia, suicidal thoughts, catatonia (condition in which the patient is rendered motionless and speechless for a period) whistling, ringing or other persistent noise in the ears tremor (shaking) flushing
Danish: Aggressiv opførsel, humørsvingninger, at se eller høre ting, som i virkeligheden ikke er der (hallucinationer), mani (sindstilstand der er karakteriseret ved episoder af overaktivitet, opstemthed eller irritabilitet), paranoia, selvmordstanker, katatoni (tilstand hvor patienten kan være ubevægelig og stum i en periode)
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 200 mg hard capsules efavirenz
Danish: LÆGEMIDLETS NAVN SUSTIVA 200 mg hårde kapsler efavirenz
English: Antimycobacterials Rifabutin/Efavirenz (300 mg once daily/600 mg once daily)
Danish: Antimykobakterielle lægemidler Rifabutin/efavirenz (300 mg én gang dagligt/600 mg én gang dagligt)
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 100 mg hard capsules efavirenz
Danish: LÆGEMIDLETS NAVN SUSTIVA 100 mg hårde kapsler efavirenz
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each hard capsule contains: efavirenz 100 mg.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver hård kapsel indeholder: Efavirenz 100 mg
English: SUSTIVA 200 mg hard capsules efavirenz
Danish: SUSTIVA 200 mg hårde kapsler (efavirenz)
English: Ritonavir/Efavirenz (500 mg twice daily/600 mg once daily)
Danish: Ritonavir/efavirenz (500 mg to gange dagligt/600 mg én gang dagligt)
English: Co-administration of efavirenz and St. John's wort or herbal preparations containing St. John's wort is contraindicated.
Danish: Samtidig administration af efavirenz og perikon eller naturlægemidler, der indeholder perikon, er kontraindiceret.
English: Fluconazole/Efavirenz (200 mg once daily/400 mg once daily)
Danish: Fluconazol/efavirenz (200 mg én gang dagligt/400 mg én gang dagligt)
English: Paroxetine/Efavirenz (20 mg once daily/600 mg once daily)
Danish: Paroxetin/efavirenz (20 mg én gang dagligt/600 mg én gang dagligt)
English: Indinavir/ritonavir/Efavirenz (800 mg twice daily/100 mg twice daily/600 mg once daily)
Danish: Indinavir/ritonavir/efavirenz (800 mg to gange dagligt/100 mg to gange dagligt/600 mg én gang dagligt)
English: Cmax: ↑ 23% (↓ 1 to ↑ 53) *
Danish: AUC: ↓ 7% (↓ 23 til ↑ 13)* Cmax: ↑ 23% (↓ 1 til ↑ 53)* Efavirenz:
English: Cmin: ↓ 82% (↓ 79 to ↓ 85) Levonorgestrel (active metabolite): AUC: ↓ 83% (↓ 79 to ↓ 87)
Danish: AUC: ↓ 64% (↓ 62 til ↓ 67) Cmax: ↓ 46% (↓ 39 til ↓ 52) Cmin: ↓ 82% (↓ 79 til ↓ 85) Levonorgestrel (aktiv metabolit): AUC: ↓ 83% (↓ 79 til ↓ 87) Cmax: ↓ 80% (↓ 77 til ↓ 83) Cmin: ↓ 86% (↓ 80 til ↓ 90) (induktion af metabolisme).
English: AUC: ↓ 36% C12: ↓ 21%
Danish: AUC: ↓ 36% C12: ↓ 21% Cmax: ↓ 36% (UGT1A1-induktion)
English: Cmax: ↑ 50% (↑ 20 to ↑ 80)
Danish: Cmax: ↑ 50% (↑ 20 til ↑ 80) (CYP2B6induktion)
English: Experience with efavirenz in patients who discontinued other antiretroviral agents of the NNRTI class is limited (see section 4.8).
Danish: Erfaring med efavirenz er begrænset hos patienter, hvor behandling med andre antiretrovirale lægemidler fra NNRTI-klassen blev seponeret (se pkt.
English: Simvastatin/Efavirenz (40 mg once daily/600 mg once daily)
Danish: Simvastatin/efavirenz (40 mg én gang dagligt/600 mg én gang dagligt)
English: SUSTIVA 50 mg hard capsules efavirenz
Danish: SUSTIVA 50 mg hårde kapsler (efavirenz)
English: AUC: ↑ 11% (↑ 5 to ↑ 18)
Danish: Ritonavir: AUC morgen: ↑ 18% (↑ 6 til ↑
English: Cmin: ↓ 44% (↓ 27 to ↓ 58) (decrease in itraconazole concentrations: CYP3A4 induction) Hydroxyitraconazole:
Danish: AUC: ↓ 39% (↓ 21 til ↓ 53) Cmax: ↓ 37% (↓ 20 til ↓ 51) Cmin: ↓ 44% (↓ 27 til ↓ 58) (fald i itraconazolkoncentrationen: CYP3A4-induktion) Hydroxyitraconazol:
English: Fosamprenavir/ritonavir/Efavirenz (700 mg twice daily/100 mg twice daily/600 mg once daily)
Danish: Fosamprenavir/ritonavir/efavirenz (700 mg to gange dagligt/100 mg to gange dagligt/600 mg én gang dagligt)
English: AUC: ↓ 18% (↓ 10 to ↓ 26) Cmax: ↓ 24% (↓ 15 to ↓ 32)
Danish: AUC: ↓ 25% (↓ 16 til ↓ 32)b Cmax: ↓ 17% (↓ 6 til ↓ 26)b
English: Valproic acid/Efavirenz (250 mg twice daily/600 mg once daily)
Danish: Valproinsyre/efavirenz (250 mg to gange dagligt/600 mg én gang dagligt)
English: Pravastatin/Efavirenz (40 mg once daily/600 mg once daily)
Danish: Pravastatin/efavirenz (40 mg én gang dagligt/600 mg én gang dagligt)
English: Skin and subcutaneous tissue disorders very common rash (11.6%)*
Danish: Hud og subkutane væv Meget almindelig
English: Fluoxetine/Efavirenz
Danish: Fluoxetin/efavirenz
English: Voriconazole/Efavirenz (200 mg twice daily/400 mg once daily)
Danish: Voriconazol/efavirenz (200 mg to gange dagligt/400 mg én gang dagligt)
English: OPIOIDS
Danish: OPIOIDER
English: Cmax: ↓ 44% (↓ 20 to ↓ 61)
Danish: AUC: ↓ 75% (↓ 62 til ↓ 84) Cmax: ↓ 44% (↓ 20 til ↓ 61)
English: What SUSTIVA is and what it is used for 2.
Danish: Virkning og anvendelse af SUSTIVA 2.
English: AUC: ↓ 34% (↓ 21 to ↓ 41)
Danish: AUC: ↓ 34% (↓ 21 til ↓ 41) Cmax: ↓ 20% (↓ 2 til ↓ 26)
English: Capsule shell: Gelatine, Sodium laurilsulfate, Titanium dioxide (E171), Silicon dioxide (E551)
Danish: Kapselskallen indeholder: Gelatine, natriumlaurilsulfat, titandioxid (E171) og siliciumdioxid (E551).
English: Since decreased concentrations of artemether, dihydroartemisinin, or lumefantrine may result in a decrease of antimalarial efficacy, caution is recommended when efavirenz and artemether/lumefantrine tablets are coadministered.
Danish: Forsigtighed tilrådes, når efavirenz og artemether/lumefantrintabletter tages samtidigt, da fald i koncentrationen af artemether, dihydroartemisinin eller lumefantrin kan resultere i nedsat effekt mod malaria.
English: If you need help in planning the best times to take your medicine, ask your doctor or pharmacist.
Danish: Spørg Deres læge eller apotek, hvis De har brug for hjælp til at planlægge, hvornår det er bedst at tage Deres medicin.
English: SUSTIVA is for oral use.
Danish: Virkning og anvendelse af SUSTIVA.
English: Cmin: ↓ 62% (↓ 44 to ↓ 75) N-monodesmethyl diltiazem: AUC: ↓ 37% (↓ 17 to ↓ 52)
Danish: AUC: ↓ 75% (↓ 59 til ↓ 84) Cmax: ↓ 64% (↓ 57 til ↓ 69) Cmin: ↓ 62% (↓ 44 til ↓ 75) N-monodesmethyl diltiazem: AUC: ↓ 37% (↓ 17 til ↓ 52) Cmax: ↓ 28% (↓ 7 til ↓ 44) Cmin: ↓ 37% (↓ 17 til ↓ 52) Efavirenz: