FrancophonIA/ELRC3.0 huggingface dataset:
English: Prolonged use of corticosteroids may produce subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.
Slovenian: Daljša uporaba kortikosteroidov lahko povzroči nastanek subkapsularnih katarakt ali glavkoma z možno poškodbo vidnih živcev in lahko spodbudi razvoj sekundarnih očesnih okužb, ki jih povzročajo glivice ali virusi.
English: Talk to your doctor before taking Neofordex if you or a member of your immediate family have suffered, or currently suffer from severe depression or manic attacks.
Slovenian: Pred začetkom jemanja zdravila Neofordex se posvetujte z zdravnikom, če imate ali ste imeli vi ali kateri koli član ožje družine hudo depresijo ali manične napade.
English: Patients should be informed of the signs and symptoms of pneumonia and be advised to seek medical attention in case of their appearance.
Slovenian: Bolnike je treba poučiti o znakih in simptomih pljučnice in jih opozoriti, da morajo, če se ti pojavijo, poiskati zdravniško pomoč.
English: • With erythropoietic medicinal products or other medicinal products that may increase the risk of thrombosis, such as hormone replacement therapy, in patients receiving thalidomide or its analogues with Neofordex (see sections 4.4 and 4.8).
Slovenian: • z eritropoetičnimi zdravili ali drugimi zdravili, ki lahko povečajo tveganje za trombozo (na primer zdravila za hormonsko nadomestno zdravljenje), pri bolnikih, ki prejemajo talidomid ali njegove analoge skupaj z zdravilom Neofordex (glejte poglavji 4.4 in 4.8);
English: After oral administration of Neofordex, dexamethasone peak plasma levels are reached at a median of three hours.
Slovenian: Po peroralni uporabi zdravila Neofordex je največja koncentracija deksametazona v plazmi dosežena po mediano treh urah.
English: − Inflammation of the eye and/or eyelids, increased tearing;
Slovenian: − vnetje očesa in/ali očesnih vek, povečano solzenje;
English: Particular care is needed when treating patients with glaucoma (or family history of glaucoma) as well as when treating patients with ocular herpes simplex, because of possible corneal perforation.
Slovenian: Posebna previdnost je potrebna pri zdravljenju bolnikov z glavkomom (ali z družinsko anamnezo glavkoma) in pri zdravljenju bolnikov s herpesom simpleks na očesu, saj lahko pride do predrtja roženice.
English: The adverse reactions observed in patients treated with dexamethasone are listed below by system organ class and frequency.
Slovenian: Neželeni učinki, ki so jih opazili pri bolnikih, zdravljenih z deksametazonom, so navedeni spodaj glede na organski sistem in pogostnost.
English: Insomnia may be minimised by administering Neofordex in the morning.
Slovenian: Tveganje za nespečnost je mogoče zmanjšati, tako da se zdravilo Neofordex vzame zjutraj.
English: Dexamethasone may cause congenital malformations (see section 5.3).
Slovenian: Deksametazon lahko povzroči kongenitalne malformacije (glejte poglavje 5.3).
English: In controlled studies, combination treatment with dexamethasone consistently showed better outcomes in terms of survival and response than single-agent dexamethasone.
Slovenian: V nadzorovanih študijah so pri kombiniranem zdravljenju z deksametazonom dosledno beležili boljše izide pri parametrih preživetja in odziva kot pri zdravljenju s samim deksametazonom.
English: Methotrexate is also used to treat rheumatism or psoriasis; - Erythropoietin (EPO, to treat anaemia) - Ciclosporin (for the treatment of psoriasis, atopic dermatitis, rheumatoid arthritis or nephrotic syndrome, and to suppress immune reactions after an organ or bone marrow transplantation) - Ephedrine (to treat asthma attacks or relieve nasal congestion).
Slovenian: Metotreksat se uporablja tudi za zdravljenje revmatizma in luskavice; - eritropoetin (EPO, za zdravljenje anemije); - ciklosporin (za zdravljenje luskavice, atopijskega dermatitisa, revmatoidnega artritisa ali nefrotskega sindroma in za zaviranje imunske odzivnosti po presaditvi organov ali kostnega mozga); - efedrin (za zdravljenje astmatičnih napadov ali zmanjšanje zamašenosti nosu).
English: Concomitant use of dexamethasone and ciclosporine should be avoided.
Slovenian: Sočasni uporabi deksametazona in ciklosporina se je treba izogibati;
English: Ciclosporin may also increase the intracellular uptake of dexamethasone.
Slovenian: Ciklosporin pa lahko poveča privzem deksametazona v celice.
English: − Thinning of the bones with increased risk of fracture, bone disease, ruptured tendon.
Slovenian: − tanjšanje kosti, ki poveča tveganje za zlom, bolezen kosti, pretrgana kita.
English: • With methotrexate, due to an increased risk of haematological toxicity.
Slovenian: • z metotreksatom, saj se poveča tveganje za hematološko toksičnost.
English: Consequently, patients with known risk factors for thromboembolism (including prior thrombosis) should be closely monitored.
Slovenian: Zato je potrebno natančno spremljanje bolnikov z znanimi dejavniki tveganja za trombembolijo (vključno s trombozo v preteklosti).
English: • With hypoglycaemic medicinal products, as dexamethasone can raise glycaemic levels and diminish glucose tolerance, with a possibility of ketoacidosis.
Slovenian: • s hipoglikemičnimi zdravili, saj lahko deksametazon zviša ravni glukoze in zmanjša toleranco za glukozo, pri čemer lahko povzroči ketoacidozo.
English: Adverse reactions to Neofordex correspond to the predictable safety profile of glucocorticoids.
Slovenian: Neželeni učinki zdravila Neofordex so skladni z varnostnim profilom, ki ga je mogoče predvideti za glukokortikoide.
English: During treatment with this medicine it is important to maintain a balanced diet.
Slovenian: Pomembno je, da med zdravljenjem s tem zdravilom uživate uravnoteženo prehrano.
English: In Pom + LD-Dex treated patients, thrombocytopenia was serious in 1.7% of patients, led to dose reduction in 6.3% of patients, to dose interruption in 8% of patients and to treatment discontinuation in 0.7% of patients.
Slovenian: Pri bolnikih, zdravljenih s Pom + LD-dex, je bila trombocitopenija resna pri 1,7 % bolnikov, vodila je k zmanjšanju odmerka pri 6,3 % bolnikov, k prekinitvi odmerjanja pri 8 % bolnikov in k prenehanju zdravljenja pri 0,7 % bolnikov.
English: − Cushing's syndrome, i.e. weight gain of the trunk and face, excessive sweating, stretch marks, visible swollen capillaries (small blood vessels) and dryness of the skin, growth of extra facial hair (especially in women) and thinning of the hair;
Slovenian: − Cushingov sindrom, tj. povečanje mase trupa in obraza, čezmerno potenje, strije, vidne povečane kapilare (majhne žilice) in suha koža, povečana poraščenost obraza (zlasti pri ženskah) in tanjšanje las;
English: What Neofordex is and what it is used for
Slovenian: Kaj je zdravilo Neofordex in za kaj ga uporabljamo
English: − Aggression, confusion, irritability, nervousness, restlessness, altered mood;
Slovenian: − agresija, zmedenost, razdražljivost, živčnost, nemirnost, spremembe razpoloženja;
English: Dexamethasone may be used with known teratogens (e.g. thalidomide, lenalidomide, pomalidomide, plerixafor), or with cytotoxic substances which are contraindicated in pregnancy.
Slovenian: Deksametazon se lahko uporablja skupaj z znanimi teratogeni (npr. s talidomidom, lenalidomidom, pomalidomidom ali pleriksaforjem) ali citotoksičnimi snovmi, katerih uporaba je med nosečnostjo kontraindicirana.
English: The combination of dexamethasone with thalidomide, lenalidomide or pomalidomide (medicines to treat multiple myeloma) increases the risk of blood clots in the veins and arteries.
Slovenian: Deksametazon v kombinaciji s talidomidom, lenalidomidom ali pomalidomidom (zdravili, ki se uporabljajo za zdravljenje multiplega mieloma) poveča tveganje za krvne strdke v venah in arterijah.
English: What Neofordex is and what it is used for 2.
Slovenian: Kaj je zdravilo Neofordex in za kaj ga uporabljamo 2.
English: The common adverse reactions to systemic corticosteroids may be associated with more serious consequences in old age, especially osteoporosis, hypertension, hypokalaemia, diabetes, susceptibility to infection and thinning of the skin.
Slovenian: Pogoste neželene reakcije na sistemske kortikosteroide so lahko v visoki starosti povezane z resnejšimi posledicami, med katerimi so predvsem osteoporoza, hipertenzija, hipokaliemija, sladkorna bolezen, dovzetnost za okužbe in tanjšanje kože.
English: Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation.
Slovenian: Da bi dosegli največjo koncentracijo apoptoznih označevalcev skupaj z večjim aktiviranjem kaspaze-3 in fragmentacijo DNA, je bila potrebna daljša izpostavljenost.
English: Dexamethasone has no clinically significant pharmacokinetic interaction with thalidomide, lenalidomide, pomalidomide, bortezomib, vincristine or doxorubicin.
Slovenian: Klinično pomembnih farmakokinetičnih interakcij deksametazona s talidomidom, lenalidomidom, pomalidomidom, bortezomibom, vinkristinom in doksorubicinom ni.
English: Tablets may be broken in two equal halves using the score line to provide the 20 mg dose.
Slovenian: Tablete se lahko po razdelilni zarezi delijo na dve enaki polovici, da se dobi 20-miligramski odmerek.
English: White, oblong (11 mm × 5.5 mm) tablet with a score-line on one face.
Slovenian: Bela podolgovata (11 mm × 5,5 mm) tableta z razdelilno zarezo na eni strani.
English: Dexamethasone apoptotic activity is enhanced by the combination with thalidomide or its analogues and with proteasome inhibitor (e.g. bortezomib).
Slovenian: Apoptotični učinek deksametazona se poveča v kombinaciji s talidomidom ali njegovimi analogi ter z zaviralcem proteasoma (kot je na primer bortezomib).
English: If you get an infection of any kind during treatment with this medicine, contact your doctor immediately.
Slovenian: Če se med zdravljenjem s tem zdravilom pri vas pojavi kakršna koli okužba, se takoj posvetujte z zdravnikom.
English: No clinical efficacy and safety studies have been conducted using Neofordex in the treatment of multiple myeloma.
Slovenian: Klinična učinkovitost in varnost Študij o klinični učinkovitosti in varnosti zdravila Neofordex pri zdravljenju multiplega mieloma niso opravili.
English: Therefore, erythropoietic medicinal products, or other medicinal products that may increase the risk of thrombosis, such as hormone replacement therapy, should be used with caution in multiple myeloma patients receiving dexamethasone with thalidomide and its analogues.
Slovenian: Zato je treba eritropoetična zdravila ali druga zdravila, ki lahko povečajo tveganje za trombozo (na primer zdravila za hormonsko nadomestno zdravljenje), pri bolnikih z multiplim mielomom, ki prejemajo deksametazon v kombinaciji s talidomidom in njegovimi analogi, uporabljati previdno.
English: Dexamethasone also down-regulated anti apoptotic genes and increased IκB-α protein levels.
Slovenian: Poleg tega je deksametazon zmanjšal izražanje antiapoptoznih genov in povečal koncentracijo beljakovin IκB-α.
English: Neofordex 40 mg tablets
Slovenian: Neofordex 40 mg tablete
English: The patient should continue anticoagulation therapy during the course of treatment with dexamethasone and thalidomide or its analogues.
Slovenian: Bolnik mora v času zdravljenja z deksametazonom in talidomidom ali njegovimi analogi še naprej prejemati antikoagulacijska zdravila.
English: The dose of the anti-hypertensive treatment may have to be adjusted during the treatment with dexamethasone.
Slovenian: Odmerek antihipertenzivnega zdravila bo med zdravljenjem z deksametazonom morda treba prilagoditi;
English: If you are elderly, some of the side effects of Neofordex may be more serious, especially thinning of the bones (osteoporosis), high blood pressure, low potassium levels, diabetes, susceptibility to infection and thinning of the skin.
Slovenian: Če ste starejša oseba, se lahko nekateri neželeni učinki zdravila Neofordex pri vas pojavijo v hujši obliki, zlasti tanjšanje kosti (osteoporoza), visok krvni tlak, nizke ravni kalija, sladkorna bolezen, dovzetnost za okužbe in tanjšanje kože.
English: Do not save the spare half tablet to take on another day as this medicine may deteriorate once divided and taken out of its packaging.
Slovenian: Druge polovice razpolovljene tablete ne hranite za drug dan, saj se kakovost zdravila, potem ko ga vzamete iz ovojnine in razpolovite, lahko poslabša.
English: What you need to know before you take Neofordex 3.
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Neofordex 3.
English: Potassium levels should be monitored during treatment.
Slovenian: Med zdravljenjem je treba spremljati ravni kalija.
English: The usual posology of dexamethasone is 40 mg once per day of administration.
Slovenian: Običajno odmerjanje deksametazona je naenkrat 40 mg na dan jemanja.
English: • With medicinal products that carry a risk of Torsades de Pointes, due to increased risk of ventricular arrhythmia.
Slovenian: • z zdravili, povezanimi s tveganjem za Torsades de Pointes, saj se poveča tveganje za ventrikularno aritmijo.
English: Paediatric population There is no relevant use of Neofordex in the paediatric population in the indication multiple myeloma.
Slovenian: Pediatrična populacija Zdravilo Neofordex ni namenjeno za uporabo pri pediatrični populaciji za indikacijo multiplega mieloma.
English: − Sensitivity, numbness, tingling or burning sensation of the skin, or pain in the hands or feet due to nerve damage, dizziness, trembling, headache, loss of or change in the sense of taste;
Slovenian: − občutljivost, odrevenelost, mravljinčenje kože ali pekoč občutek na koži, bolečina v dlaneh ali stopalih zaradi poškodovanih živcev, omotica, tresenje, glavobol, izguba ali sprememba sposobnosti okušanja;
English: Active viral disease (especially viral hepatitis, herpes, varicella, shingles).
Slovenian: Aktivna virusna bolezen (še zlasti virusni hepatitis, herpes, norice ali pasovec).
English: Parasite eradication must be successfully terminated before dexamethasone use (see section 4.4).
Slovenian: Pred uporabo deksametazona je treba uspešno odpraviti parazite (glejte poglavje 4.4);
English: If you think you may have had contact with anyone with these conditions, you should inform your doctor immediately.
Slovenian: Če mislite, da ste bili v stiku z osebo, ki ima takšno bolezen, takoj obvestite zdravnika.
English: The incidence of predictable adverse reactions, including adrenal atrophy, correlates with dose, timing of administration and the duration of treatment (see section 4.4).
Slovenian: Incidenca predvidljivih neželenih učinkov, vključno z atrofijo nadledvične žleze, je povezana z odmerkom, časom uporabe in trajanjem zdravljenja (glejte poglavje 4.4).
English: • With hypokalaemic medicinal products: hypokalemic diuretics, single or in combination, laxatives, tetracosactide, intravenous amphotericin B, due to increased risk of hypokalaemia.
Slovenian: • z zdravili, ki znižujejo ravni kalija, tj. s tovrstnimi diuretiki kot samostojnimi zdravili ali v kombinaciji, odvajali, tetrakozaktidom in intravenskim amfotericinom B, saj se poveča tveganje za hipokaliemijo.
English: The dose and administration frequency varies with the therapeutic protocol and the associated treatment(s).
Slovenian: Odmerek in pogostnost uporabe sta odvisna od protokola zdravljenja in zdravil v kombinaciji.
English: Any hypokalaemia should be corrected and patients should be monitored clinically, for electrolytes and by electrocardiograpy.
Slovenian: Odpraviti je treba kakršno koli obliko hipokaliemije in klinično spremljati bolnike z meritvami elektrolitov ter elektrokardiogramom;
English: Patients should be instructed to seek medical care if they develop symptoms such as shortness of breath, chest pain, arm or leg swelling.
Slovenian: Bolnike je treba opozoriti, da morajo poiskati zdravniško pomoč, če opazijo simptome, kot so kratka sapa, bolečine v prsnem košu in otekanje rok ali nog.
English: Talk to your doctor before taking Neofordex - if you have liver or kidney disease, - if you have heart disease or you have recently had a heart attack, - if you have high blood pressure, high cholesterol or you are a smoker, - if you have diabetes or if there is a history of diabetes in your family, - if you have osteoporosis, especially if you are a woman who has been through the menopause, - if you have glaucoma (increased eye pressure) or if there is a history of glaucoma in your family, - if you have myasthenia gravis (a disease affecting the muscles), - if you have a peptic ulcer (ulcer in your stomach or duodenum), or a history of peptic ulcers, stomach bleeding or perforation, - if you have inflammation of the colon, diverticulitis, or have recently had surgery on the intestine, - if you have inflammation of a tendon.
Slovenian: Pred začetkom jemanja zdravila Neofordex obvestite zdravnika: - če imate bolezen jeter ali ledvic; - če imate bolezen srca ali če ste pred kratkim preboleli srčno kap; - če imate visok krvni tlak, visoke ravni holesterola ali če kadite; - če imate sladkorno bolezen ali če imate sladkorno bolezen v družinski zdravstveni zgodovini; - če imate osteoporozo, zlasti če ste ženska in je pri vas že nastopila menopavza; - če imate glavkom (povišan očesni tlak) ali če imate glavkom v družinski zdravstveni zgodovini; - če imate miastenijo gravis (bolezen, ki prizadene mišice); - če imate peptično razjedo (razjedo v želodcu ali dvanajstniku) ali če ste v preteklosti imeli želodčne razjede, krvavitve v želodcu ali predrtje želodca; - če imate vnetje debelega črevesa, vnetje slepiča (divertikulitis), ali če ste pred kratkim prestali operacijo črevesja; - če imate vnetje kite.
English: • Anticonvulsants that are hepatic enzyme inducers: carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone, due to the reduction of dexamethasone plasma levels and hence its efficacy.
Slovenian: • antikonvulzivi, ki inducirajo jetrne encime - karbamazepin, fosfenitoin, fenobarbital, fenitoin in primidon, saj zmanjšajo koncentracije deksametazona v plazmi in s tem njegovo učinkovitost;
English: − Stroke, difficulties in coordination or movement, fainting;
Slovenian: − možganska kap, težave s koordinacijo in pri gibanju, omedlevica;
English: Women should avoid pregnancy during Neofordex treatment.
Slovenian: Ženske morajo preprečiti zanositev med jemanjem zdravila Neofordex.
English: − Increased pressure in the eye including glaucoma, choroid and retinal disorders (chorioretinopathy);
Slovenian: − povišan tlak v očesu, vključno z glavkomom, motnje žilnice in mrežnice (horioretinopatija);
English: In addition, amphotericin B carries a risk of cardiac enlargement and cardiac failure with concurrent use.
Slovenian: Poleg tega je sočasna uporaba amfotericina B povezana tudi s tveganjem za povečanje srca in srčno popuščanje;
English: Neofordex is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products.
Slovenian: Zdravilo Neofordex je indicirano za zdravljenje simptomatičnega multiplega mieloma pri odraslih v kombinaciji z drugimi zdravili.
English: − Slow wound healing, acne, thinning of the skin, bruising, red or purple discolorations on the skin
Slovenian: − počasno celjenje ran, akne, tanjšanje kože, podplutbe, rdeče ali škrlatno rdeče lise na koži (purpura);
English: Close clinical supervision is required to avoid life-threatening reactions.
Slovenian: Da se preprečijo smrtno nevarne neželene reakcije, je potrebno natančno klinično spremljanje.
English: The efficacy of oral contraceptives may be reduced during dexamethasone treatment (see section 4.5).
Slovenian: Med zdravljenjem z deksametazonom se lahko zmanjša učinkovitost peroralnih kontraceptivov (glejte poglavje 4.5).
English: In post marketing experience tumour lysis syndrome (TLS) has been reported in patients with haematological malignancies following the use of dexamethasone alone or in combination with other chemotherapeutic agents.
Slovenian: V obdobju trženja zdravila so pri bolnikih s hematološkimi malignimi obolenji poročali o sindromu lize tumorja (TLS, tumour lysis syndrome) po uporabi deksametazona, samostojno ali skupaj z drugimi kemoterapevtiki.
English: Concomitant administration of dexamethasone with substances that are metabolised via CYP3A4 or transported by P-gp could lead to increased clearance and decreased plasma concentrations of these substances:
Slovenian: Sočasna uporaba deksametazona z učinkovinami, ki se presnavljajo s CYP3A4 ali prenašajo s P-gp, lahko povzroči povečanje očistka in zmanjšanje koncentracij teh učinkovin v plazmi:
English: In patients not already prescribed bisphosphonates for multiple myeloma related bone disease, bisphosphonates should be considered, particularly if risk factors for osteoporosis are present.
Slovenian: Zato je treba spremljati ravni kalcija in vitamina D. Pri bolnikih, ki še nimajo predpisanih bisfosfonatov za bolezni kosti, povezane z multiplim mielomom, je treba razmisliti o njihovi uvedbi, zlasti če so prisotni dejavniki tveganja za osteoporozo.
English: Treatment with this medicine may cause tendon inflammation.
Slovenian: Zdravljenje s tem zdravilom lahko povzroči vnetje kit.
English: − Bacterial, viral or fungal infections, including pneumonia, shingles, infections of the nose, mouth, tonsils or throat, bronchitis, herpes, bladder infection;
Slovenian: − bakterijske, virusne ali glivične okužbe, ki vključujejo pljučnico, pasovec, okužbe nosu, ust, tonzil ali grla, bronhitis, herpes in okužbo sečnega mehurja;
English: − Development of diabetes, loss or increase of appetite, weight gain or weight loss, water retention;
Slovenian: − razvoj sladkorne bolezni, izguba teka ali povečan tek, povečanje ali zmanjšanje telesne mase, zastajanje vode;
English: − Muscle wasting, pain of the muscles, joints, bones or limbs;
Slovenian: − propadanje mišic, bolečine v mišicah, sklepih, kosteh ali okončinah;
English: − Tiredness, weakness, swelling of the body and face.
Slovenian: − utrujenost, šibkost, otekanje telesa in obraza;
English: Lactose monohydrate Microcrystalline cellulose Magnesium stearate Colloidal anhydrous silica
Slovenian: 6.1 Seznam pomožnih snovi laktoza monohidrat mikrokristalna celuloza magnezijev stearat koloidni brezvodni silicijev dioksid
English: No data on male fertility are available.
Slovenian: Podatki o moški plodnosti niso na voljo.
English: No dose adjustment is needed in the treatment of multiple myeloma.
Slovenian: Pri zdravljenju multiplega mieloma ni treba prilagajati odmerkov.
English: In reproductive toxicity studies in mice, rats, hamsters, rabbits and dogs, dexamethasone has led to embryo-fetal malformations such as increase in cleft palate and skeletal defects; decreases in thymus, spleen and adrenal weight; lung, liver, and kidney abnormalities; and inhibition of growth.
Slovenian: V študijah o vplivu na sposobnost razmnoževanja, opravljenih na miših, podganah, hrčkih, kuncih in psih, je deksametazon povzročil embriofetalne malformacije, na primer povečanje števila primerov palatoshize in skeletnih okvar; zmanjšanje mase priželjca, vranice in nadledvične žleze; anomalije pljuč, jeter in ledvic; ter zaviranje rasti.
English: Dexamethasone crosses the blood-brain barrier and the placental barrier and passes into breast milk.
Slovenian: Deksametazon prehaja skozi krvno-možgansko pregrado in skozi placento ter se izloča v materino mleko.
English: − Cough, breathing difficulties, difficulties speaking, sore throat or mouth, hoarseness, dry mouth,
Slovenian: − kašelj, težave z dihanjem, težave pri govorjenju, vnetje žrela ali ustne votline, hripavost, suha usta,
English: Febrile neutropenia (FN) was experienced in 6.7% of patients who received Pom + LD-Dex, and in no patients who received HD-Dex.
Slovenian: Febrilna nevtropenija (FN) se je pojavila pri 6,7 % bolnikov, ki so prejemali Pom + LD-dex, in pri nobenem bolniku, ki je prejemal HD-dex.
English: What you need to know before you take Neofordex
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Neofordex
English: A minor part of administered dexamethasone is excreted unchanged by the kidney.
Slovenian: Manjša količina odmerka deksametazona se izloči skozi ledvice v nespremenjeni obliki.