FrancophonIA/ELRC3.0 huggingface dataset:
English: You should also tell your doctor: if you are on a low-salt diet if you have signs such as abnormal thirst, dry mouth, general weakness, drowsiness, muscle pain or cramps, nausea, vomiting, or an abnormally fast heart beat which may indicate an excessive effect of hydrochlorothiazide (contained in CoAprovel) if you experience an increased sensitivity of the skin to the sun with symptoms of sunburn (such as redness, itching, swelling, blistering) occurring more quickly than normal if you are going to have an operation (surgery) or be given anaesthetics if you have changes in your vision or pain in one or both of your eyes while taking CoAprovel.
Slovenian: Svojemu zdravniku morate tudi povedati:  če imate dieto z zmanjšanim vnosom soli če imate znake, kot so nenormalna žeja, suha usta, splošna oslabelost, zaspanost, bolečine ali krči v mišicah, siljenje na bruhanje, bruhanje ali nenormalno hiter srčni utrip, ki so lahko posledica prevelikega učinka hidroklorotiazida (ki ga vsebuje zdravilo CoAprovel) če vaša koža postane bolj občutljiva na sonce oziroma se znaki sončnih opeklin (kot so pordelost, srbenje, otekline, pojav mehurjev) pojavijo hitreje kot normalno  če imate predvideno operacijo (kirurški poseg) ali boste prejeli anestetik če se med jemanjem zdravila CoAprovel pojavijo spremembe vida ali bolečina v enem ali obeh očesih.
English: In these patients, an incremental blood pressure lowering effect was observed for both systolic blood pressure (SBP) and diastolic blood pressure (DBP) (13.3 and 8.3 mm Hg, respectively).
Slovenian: Pri teh bolnikih so opazili stopnjevanje učinka na znižanje sistoličnega in diastoličnega krvnega tlaka (sistoličnega za 13,3 mmHg, diastoličnega za 8,3 mmHg).
English: 14 tablets 28 tablets 56 tablets 56 x 1 tablets 98 tablets
Slovenian: 14 tablet 28 tablet 56 tablet 56 x 1 tableta 98 tablet
English: Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloremia, hyponatraemia) and dehydration resulting from excessive diuresis.
Slovenian: Po prevelikem odmerjanju hidroklorotiazida se pojavita izguba elektrolitov (hipokaliemija, hipokloremija, hiponatriemija) in dehidracija, ki sta posledica čezmerne diureze.
English: Additional information on individual components: in addition to the adverse reactions listed above for the combination product, other adverse reactions previously reported with one of the individual components may be potential adverse reactions with CoAprovel.
Slovenian: Dodatni podatki o posameznih učinkovinah: poleg zgoraj naštetih neželenih učinkov, ki se lahko pojavijo med uporabo kombiniranega zdravila, se utegnejo med jemanjem zdravila CoAprovel pojaviti tudi neželeni učinki, o katerih so predhodno poročali pri jemanju posamezne zdravilne učinkovine.
English: CoAprovel is a combination of two active substances, irbesartan and hydrochlorothiazide.
Slovenian: Zdravilo CoAprovel je kombinacija dveh zdravilnih učinkovin, irbesartana in hidroklorotiazida.
English: CoAprovel contains lactose.
Slovenian: Zdravilo CoAprovel vsebuje laktozo.
English: Acute Myopia and Secondary Acute Angle-Closure Glaucoma: sulfonamide drugs or sulfonamide derivative drugs can cause an idiosyncratic reaction, resulting in transient myopia and acute angleclosure glaucoma.
Slovenian: Akutna kratkovidnost in sekundarni akutni glavkom z zaprtim zakotjem: zdravila, ki vsebujejo sulfonamide ali njihove derivate lahko povzročijo idiosinkratično reakcijo s posledično prehodno kratkovidnostjo in akutnim glavkomom z zaprtim zakotjem.
English: Dual blockade of the renin-angiotensin-aldosterone system (RAAS): there is evidence that the concomitant use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure).
Slovenian: Dvojna blokada sistema renin-angiotenzin-aldosteron (RAAS): obstajajo dokazi, da sočasna uporaba zaviralcev ACE, blokatorjev receptorjev angiotenzina II ali aliskirena poveča tveganje za hipotenzijo, hiperkaliemijo in zmanjšano delovanje ledvic (vključno z akutno odpovedjo ledvic).
English: CoAprovel should not be given to children under 18 years of age.
Slovenian: Otroci, mlajši od 18 let, zdravila CoAprovel ne smejo jemati.
English: Additional information on hydrochlorothiazide interactions: when administered concurrently, the following medicinal products may interact with thiazide diuretics:
Slovenian: Dodatni podatki o medsebojnem delovanju s hidroklorotiazidom: ob sočasni uporabi se lahko pojavijo interakcije med tiazidnimi diuretiki in naslednjimi zdravili:
English: interstitial nephritis, renal dysfunction
Slovenian: intersticijski nefritis, motnje delovanja ledvic
English: Hypotension - Volume-depleted patients: CoAprovel has been rarely associated with symptomatic hypotension in hypertensive patients without other risk factors for hypotension.
Slovenian: Hipotenzija - zmanjšan intravaskularni volumen: simptomatska hipotenzija se pri bolnikih z zvišanim krvnim tlakom, ki jemljejo zdravilo CoAprovel, nimajo pa drugih dejavnikov tveganja za hipotenzijo, pojavi le redko.
English: anaphylactic reactions, toxic epidermal necrolysis, necrotizing angitis (vasculitis, cutaneous vasculitis), cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, photosensitivity reactions, rash, urticaria
Slovenian: anafilaktične reakcije, toksična epidermalna nekroliza, nekrotizirajoči angiitis (vaskulitis, vnetje kožnih žil ali mezgovnic), reakcije, podobne kožnemu eritematoznemu lupusu, reaktivacija kožnega eritematoznega lupusa, fotosenzitivne reakcije, izpuščaj, urtikarija
English: Furthermore, renal clearance of lithium is reduced by thiazides so the risk of lithium toxicity could be increased with CoAprovel.
Slovenian: Tiazidi zmanjšujejo ledvični očistek litija, zato se med zdravljenjem z zdravilom CoAprovel poveča nevarnost zastrupitve z litijem.
English: Following oral or intravenous administration of 14C irbesartan, 80-85% of the circulating plasma radioactivity is attributable to unchanged irbesartan.
Slovenian: Po peroralni ali intravenski uporabi irbesartana 14C je v obtoku 80 do 85% nespremenjene učinkovine.
English: Common side effects (may affect up to 1 in 10 people): nausea/vomiting abnormal urination fatigue dizziness (including when getting up from a lying or sitting position) blood tests may show raised levels of an enzyme that measures the muscle and heart function (creatine kinase) or raised levels of substances that measure kidney function (blood urea nitrogen, creatinine).
Slovenian: siljenje na bruhanje/bruhanje nenormalno uriniranje utrujenost omotica (tudi pri vstajanju iz ležečega ali sedečega položaja) krvne preiskave lahko pokažejo zvišanje vrednosti encima, ki kaže na delovanje mišic in srca (encim kreatin-kinaza), ali zvišanje vrednosti snovi, ki so merilo delovanja ledvic (dušik sečnine v krvi, kreatinin).
English: The active substances are irbesartan and hydrochlorothiazide.
Slovenian: Zdravilni učinkovini sta irbesartan in hidroklorotiazid.
English: Your doctor will instruct you how to switch from the previous treatment to CoAprovel.
Slovenian: Povedal vam bo tudi, kako prenehati jemati dosedanje zdravilo in kako začeti zdravljenje z zdravilom CoAprovel.
English: 14 - 28 - 56 - 84 - 98 tablets: Mon
Slovenian: 14 - 28 - 56 - 84 - 98 tablet: Pon
English: Carbamazepine: concomitant use of carbamazepine and hydrochlorothiazide has been associated with the risk of symptomatic hyponatraemia.
Slovenian: Karbamazepin: sočasna uporaba karbamazepina in hidroklorotiazida je povezana s tveganjem za pojav simptomatske hiponatriemije, zato je v tem primeru treba spremljati vrednosti elektrolitov.
English: Non-melanoma skin cancer:
Slovenian: Nemelanomski kožni rak:
English: There is no clinical experience with CoAprovel in patients with hepatic impairment.
Slovenian: Kliničnih izkušenj z uporabo zdravila CoAprovel pri bolnikih z jetrno okvaro ni.
English: General disorders and administration site conditions:
Slovenian: Splošne težave in spremembe na mestu aplikacije:
English: While hydrochlorothiazide is a sulfonamide, only isolated cases of acute angleclosure glaucoma have been reported so far with hydrochlorothiazide.
Slovenian: Hidroklorotiazid je sicer sulfonamid, vendar pa so do sedaj med njegovo uporabo poročali le o posameznih primerih akutnega glavkoma z zaprtim zakotjem.
English: Due to the hydrochlorothiazide component, CoAprovel is not recommended for patients with severe renal dysfunction (creatinine clearance < 30 ml/min).
Slovenian: Zdravilo CoAprovel vsebuje hidroklorotiazid, zato za bolnike s hudo motenim delovanjem ledvic (očistek kreatinina < 30 ml/min) ni primeren.
English: Undesirable effects where the frequency is not known are: headache, ringing in the ears, cough, taste disturbance, indigestion, pain in joints and muscles, liver function abnormal and impaired kidney function, increased level of potassium in your blood and allergic reactions such as rash, hives, swelling of the face, lips, mouth, tongue or throat.
Slovenian: Neželeni učinki, katerih pogostnost ni znana, so: glavobol, zvonjenje v ušesih, kašelj, motnje okušanja, prebavne motnje, bolečine v sklepih in mišicah, nenormalno delovanje jeter, okvara delovanja ledvic, zvišanje vrednosti kalija v krvi in alergijske reakcije, kot so izpuščaj, koprivnica in lokalizirana oteklina obraza, ustnic, ust, jezika ali žrela.
English: The use of HCTZ may also need to be reconsidered in patients who have experienced previous NMSC (see also section 4.8).
Slovenian: Poleg tega bi bilo morda treba ponovo premisliti o uporabi hidroklorotiazida pri bolnikih, ki so že preboleli nemelanomskega kožnega raka (glejte tudi poglavje
English: Twelve percent (12%) of patients were diabetic, 34% were hyperlipidemic and the most frequent cardiovascular condition was stable angina pectoris in 3.5% of the participants.
Slovenian: Najpogostejša bolezen srca je bila stabilna angina pektoris, ki jo je imelo 3,5% vključenih bolnikov.
English: CoAprovel is a combination of an angiotensin-II receptor antagonist, irbesartan, and a thiazide diuretic, hydrochlorothiazide.
Slovenian: Zdravilo CoAprovel je kombinacija irbesartana, antagonista angiotenzina II, in tiazidnega diuretika hidroklorotiazida.
English: Severe hepatic impairment, biliary cirrhosis and cholestasis The concomitant use of CoAprovel with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (glomerular filtration rate (GFR) <60 ml/min/1.73 m²) (see sections 4.5 and 5.1).
Slovenian: Huda jetrna okvara, biliarna ciroza ali holestaza+ Sočasna uporaba zdravila CoAprovel in zdravil, ki vsebujejo aliskiren, je kontraindicirana pri bolnikih s sladkorno boleznijo ali z okvaro ledvic (hitrost glomerularne filtracije < 60 ml/min/1,73 m2) (glejte poglavji 4.5 in 5.1).
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypokalaemia, hyponatraemia, and hypochloremic alkalosis).
Slovenian: Tiazidni diuretiki, vključno s hidroklorotiazidom, lahko porušijo ravnovesje tekočin ali elektrolitov (hipokaliemija, hiponatriemija in hipokloremična alkaloza).
English: 14 - 28 - 56 - 98 tablets: Mon
Slovenian: 14 - 28 - 56 - 98 tablet: Pon
English: transient blurred vision, xanthopsia, acute myopia and secondary acute angle-closure glaucoma
Slovenian: prehodno zamegljen vid, ksantopsija, akutna kratkovidnost in sekundarni akutni glavkom z zaprtim zakotjem
English: (hyperkalaemia, hypotension and renal dysfunction) were more frequently reported in the aliskiren group than in the placebo group.
Slovenian: Tudi resni interesantni neželeni učinki (hiperkaliemija, hipotenzija in disfunkcija ledvic) so bili v skupini, ki je prejemala aliskiren, pogostejši kot v skupini, ki je prejemala placebo.
English: aplastic anaemia, bone marrow depression, neutropenia/agranulocytosis, haemolytic anaemia, leucopenia, thrombocytopenia
Slovenian: aplastična anemija, zavora delovanja kostnega mozga, nevtropenija/agranulocitoza, hemolitična anemija, levkopenija, trombocitopenija
English: CoAprovel is used to treat high blood pressure, when treatment with irbesartan or hydrochlorothiazide alone did not provide adequate control of your blood pressure.
Slovenian: Zdravilo CoAprovel uporabljamo za zdravljenje zvišanega krvnega tlaka, če pri zdravljenju samo z irbesartanom ali samo s hidroklorotiazidom krvni tlak ni bil zadostno nadzorovan.
English: Potassium-sparing diuretics, potassium supplements or potassium-containing salts substitutes should be co-administered cautiously with CoAprovel (see section 4.5).
Slovenian: Pri hkratnem zdravljenju z diuretiki, ki varčujejo kalij, pripravki s kalijem, nadomestki soli, ki vsebujejo kalij, in zdravilom CoAprovel je potrebna posebna previdnost (glejte poglavje 4.5).
English: The following changes, observed in rats and macaques receiving the irbesartan/hydrochlorothiazide combination at 10/10 and 90/90 mg/kg/day, were also seen with one of the two medicinal products alone and/or were secondary to decreases in blood pressure (no significant toxicologic interactions were observed): kidney changes, characterized by slight increases in serum urea and creatinine, and hyperplasia/hypertrophy of the juxtaglomerular apparatus, which are a direct consequence of the interaction of irbesartan with the renin-angiotensin system; slight decreases in erythrocyte parameters (erythrocytes, haemoglobin, haematocrit); stomach discoloration, ulcers and focal necrosis of gastric mucosa were observed in few rats in a 6 months toxicity study at irbesartan 90 mg/kg/day, hydrochlorothiazide 90 mg/kg/day, and irbesartan/hydrochlorothiazide 10/10 mg/kg/day.
Slovenian: Pri podganah in opicah, ki so prejemale kombinacijo 10 mg irbesartana in 10 mg hidroklorotiazida na kg/dan ter 90 mg irbesartana in 90 mg hidroklorotiazida na kg/dan, so se po znižanju krvnega tlaka (pri čemer niso opazili pomembnih toksikoloških interakcij) zaradi uporabe ene učinkovine ali kombiniranega dajanja pojavile naslednje spremembe:  ledvične spremembe so se kazale kot blago zvečanje sečnine in kreatinina v serumu ter hiperplazija/hipertrofija jukstaglomerulnega aparata, kar je neposredna posledica interakcije med irbesartanom in sistemom renin-angiotenzin;  blago zmanjšanje eritrocitnih parametrov (eritrocitov, hemoglobina in hematokrita);  pri nekaj podganah, ki so v študiji toksičnosti 6 mesecev dobivale po 90 mg irbesartana na kg/dan in 90 mg hidroklorotiazida na kg/dan ter kombinacijo irbesartana in hidroklorotiazida (10 mg/10 mg/kg/dan), so opazili spremembo barve želodca, razjede in fokalno nekrozo želodčne sluznice; teh lezij pri opicah ni bilo; znižanje kalija v serumu med uporabo hidroklorotiazida, ki je bilo med kombiniranim dajanjem z irbesartanom manj izrazito.
English: In addition to the side effects listed above, chest pain, severe allergic reactions (anaphylactic shock), and decrease in the number of platelets (a blood cell essential for the clotting of the blood) have also been reported.
Slovenian: Neželeni učinki, ki so povezani z jemanjem irbesartana samega Poleg zgoraj naštetih neželenih učinkov so poročali tudi o pojavu bolečine v prsnem košu, hudih alergijskih reakcijah (anafilaktični šok) in zmanjšanju števila trombocitov (krvne celice, ki so nujne za strjevanje krvi).
English: orthostatic dizziness
Slovenian: ortostatska omotica
English: The use of CoAprovel during breast feeding is not recommended.
Slovenian: Uporaba zdravila CoAprovel med dojenjem ni priporočljiva.
English: Therefore, the combination of lithium and CoAprovel is not recommended (see section 4.4).
Slovenian: Sočasna uporaba litija in zdravila CoAprovel zato ni priporočljiva (glejte poglavje 4.4).
English: Unit dose blister packs of 56 x 1 film-coated tablet for delivery in hospitals are also available.
Slovenian: Za uporabo v bolnišnicah so na voljo tudi v enoodmernih pretisnih omotih s 56 x 1 filmsko obloženo tableto.
English: Irbesartan/hydrochlorothiazide combination
Slovenian: Kombinacija irbesartan/hidroklorotiazid
English: Adequate monitoring of serum potassium in patients at risk is recommended (see section 4.4).
Slovenian: Pri bolnikih s povečanim tveganjem je priporočljivo nadzirati vrednosti kalija v serumu (glejte poglavje 4.4).
English: CoAprovel should not be used in patients with severe renal impairment (creatinine clearance < 30 ml/min) (see section 4.3).
Slovenian: CoAprovel se pri bolnikih s hudo ledvično okvaro (očistek kreatinina < 30 ml/min) ne sme uporabljati (glejte poglavje 4.3).
English: Immune system disorders:
Slovenian: Bolezni imunskega sistema:
English: After either oral or intravenous administration of 14C irbesartan, about 20% of the radioactivity is recovered in the urine,
Slovenian: Po peroralni ali intravenski uporabi irbesartana 14C se s sečem izloči približno 20% radioaktivne snovi, preostanek pa z blatom.
English: Aliskiren-containing products or ACE-inhibitors: clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone system (RAAS) through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4 and 5.1).
Slovenian: Zdravila, ki vsebujejo aliskiren ali zaviralci ACE: podatki kliničnih preskušanj so pokazali, da je dvojna blokada sistema renin-angiotenzin-aldosteron (RAAS) s hkratno uporabo zaviralcev ACE, blokatorjev receptorjev angiotenzina II ali aliskirena povezana z večjo pogostnostjo neželenih učinkov, npr. hipotenzije, hiperkaliemije in zmanjšanega delovanja ledvic (vključno z akutno odpovedjo ledvic) kot uporaba enega samega zdravila, ki deluje na RAAS (glejte poglavja 4.3, 4.4. in
English: Uncommon side effects (may affect up to 1 in 100 people): diarrhoea low blood pressure fainting heart rate increased flushing swelling sexual dysfunction (problems with sexual performance) blood tests may show lowered levels of potassium and sodium in your blood.
Slovenian: driska nizek krvni tlak omedlevica hiter srčni utrip zardevanje otekline spolne motnje (težave pri spolnih odnosih) krvne preiskave lahko pokažejo znižane vrednosti kalija in natrija v krvi.
English: Skin and subcutaneous tissue disorders:
Slovenian: Bolezni kože in podkožja:
English: Unit dose blister packs of 56 x 1 tablet for delivery in hospitals are also available.
Slovenian: Za uporabo v bolnišnicah so na voljo tudi v enoodmernih pretisnih omotih s 56 x 1 tableto.
English: What CoAprovel contains
Slovenian: Kaj vsebuje navodilo
English: Side effects reported since the launch of CoAprovel Some undesirable effects have been reported since marketing of CoAprovel.
Slovenian: Neželeni učinki, o katerih so poročali po prihodu zdravila CoAprovel na tržišče Po prihodu zdravila CoAprovel na tržišče so poročali še o nekaterih drugih neželenih učinkih.
English: Calcium salts: thiazide diuretics may increase serum calcium levels due to decreased excretion.
Slovenian: Kalcijeve soli: tiazidni diuretiki lahko zmanjšajo izločanje kalcija in tako zvišajo njegovo serumsko koncentracijo.
English: Colestyramine and Colestipol resins: absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Slovenian: Holestiramin in holestipol: absorpcija hidroklorotiazida je zaradi anionskih izmenjevalnih smol motena.
English: Medicinal products affecting potassium: the potassium-depleting effect of hydrochlorothiazide is attenuated by the potassium-sparing effect of irbesartan.
Slovenian: Zdravila, ki vplivajo na kalij: zmanjševanje kalija, ki ga povzroča hidroklorotiazid, omili irbesartan, ki varčuje s kalijem.
English: Based on available data from epidemiological studies, cumulative dosedependent association between HCTZ and NMSC has been observed.
Slovenian: Na podlagi obstoječih podatkov epidemioloških študij so ugotovili, da obstaja razmerje med kumulativnim odmerkom hidroklorotiazida in nemelanomskim kožnim rakom.
English: Fertility
Slovenian: aritmija
English: No dosage adjustment of CoAprovel is necessary in patients with mild to moderate hepatic impairment (see section 4.3).
Slovenian: Pri bolnikih z blago do zmerno jetrno okvaro prilagoditev odmerka ni potrebna (glejte poglavje 4.3).
English: tinnitus
Slovenian: tinitus
English: nausea/vomiting
Slovenian: navzea/bruhanje
English: CoAprovel is not indicated in patients with severe hepatic impairment.
Slovenian: Zdravilo CoAprovel ni primerno za bolnike s hudo jetrno okvaro.
English: Exposure to AIIRA therapy during the second and third trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia).
Slovenian: Znano je, da izpostavljenost antagonistom angiotenzina II v drugem in tretjem trimesečju nosečnosti lahko povzroči fetotoksične učinke pri človeku (zmanjšano delovanje ledvic, oligohidramnij, zapoznela zakostenitev lobanje) in toksične učinke pri novorojenčku (odpoved ledvic, hipotenzija, hiperkaliemija) (glejte poglavje 5.3).
English: abnormal urination
Slovenian: motnje uriniranja
English: Two large randomised, controlled trials (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)) have examined the use of the combination of an ACE-inhibitor with an angiotensin II receptor blocker.
Slovenian: Uporabo zaviralca ACE v kombinaciji z blokatorjem receptorjev angiotenzina II so raziskali v dveh velikih randomiziranih, kontroliranih preskušanjih: ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) in VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes).
English: Anti-doping test: hydrochlorothiazide contained in this medicinal product could produce a positive analytic result in an anti-doping test.
Slovenian: Test za ugotavljanje jemanja nedovoljenih substanc (antidopinški test): zaradi hidroklorotiazida, ki ga zdravilo vsebuje, je lahko test za ugotavljanje jemanja nedovoljenih poživil pozitiven.
English: Less than 2% of the dose is excreted in the urine as unchanged irbesartan.
Slovenian: nespremenjeni obliki se s sečem izloči manj kot 2% odmerka.
English: General: in patients whose vascular tone and renal function depend predominantly on the activity of the renin-angiotensin-aldosterone system (e.g. patients with severe congestive heart failure or underlying renal disease, including renal artery stenosis), treatment with angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists that affect this system has been associated with acute hypotension, azotaemia, oliguria, or rarely acute renal failure (see section 4.5).
Slovenian: Splošno: pri bolnikih, pri katerih sta tonus žilja in delovanje ledvic odvisna predvsem od delovanja sistema renin-angiotenzin-aldosteron (na primer pri bolnikih s hudo kongestivno srčno insuficienco ali ledvično boleznijo, vključno s stenozo ledvične arterije), se lahko med zdravljenjem z zaviralci angiotenzin-konvertaze ali antagonisti angiotenzina II, ki vplivajo na ta sistem, pojavijo akutna hipotenzija, azotemija, oligurija ali redko akutna ledvična odpoved (glejte poglavje 4.5).
English: Medicinal products affected by serum potassium disturbances: periodic monitoring of serum potassium is recommended when CoAprovel is administered with medicinal products affected by serum potassium disturbances (e.g. digitalis glycosides, antiarrhythmics).
Slovenian: Zdravila, na katera vpliva serumska koncentracija kalija: med hkratnim zdravljenjem z zdravilom CoAprovel in drugimi zdravili, na katerih delovanje vpliva serumska koncentracija kalija (npr. z digitalisovimi glikozidi, antiaritmiki), je priporočeno redno preverjanje kalija v serumu.
English: weakness, muscle spasm
Slovenian: oslabelost, mišični krč
English: Uncommon: may affect up to 1 in 100 people
Slovenian: Občasni neželeni učinki (pojavijo se lahko pri največ 1 od 100 bolnikov)
English: jaundice hepatitis, abnormal liver function
Slovenian: zlatenica hepatitis, motnje delovanja jeter