FrancophonIA/ELRC3.0 huggingface dataset:
English: According to the EFSA summary report, 2010, 24% of Salmonella spp isolates from breeding, layer and broiler flocks were resistant (defined by epidemiological cut-off values) to ciprofloxacin.
Spanish: Available online at www.efsa.europa.eu/efsajournal correspondiente a 2010, el 24 % de las cepas de especies de Salmonella en granjas de aves reproductoras, gallinas ponedoras y de engorde eran resistentes (según la definición de los valores de corte epidemiológicos) al ciprofloxacino.
English: Enrofloxacin 10% Solution for oral use
Spanish: Enrofloxacin 10% Solución oral
English: Poultry and pigs
Spanish: Aves de corral y cerdos
English: Chickens and rabbits
Spanish: Pollos y conejos
English: Luxembourg Global Vet Health S.L.
Spanish: Luxemburgo Global Vet Health S.L.
English: isolation rate; however, in severe experimental infections, dose rates of 35 and 66 mg/kg bw reduced mortality and the severity of the pathological findings.
Spanish: Los estudios demostraron que una dosis de 10 mg/kg de peso corporal durante 5 días controlaba los signos clínicos en condiciones de campo pero que solo reducía la tasa de cepas reaisladas; sin embargo, en las infecciones experimentales graves, las dosis de 35 y 66 mg/kg de peso corporal redujeron la mortalidad y la gravedad de los signos patológicos.
English: Netherlands Krka d.d.
Spanish: Países Bajos Krka d.d.
English: EFSA Journal 2009; 7(11):1372.
Spanish: EFSA Journal 2009; 7(11):1372.http://www.efsa.europa.eu/en/scdocs/doc/1372.pdf
English: Romania Krka d.d.
Spanish: Rumanía Krka d.d.
English: Belgium HIPRA LABORATORIOS Avda.
Spanish: HIPRA LABORATORIOS Avda.
English: http://www.efsa.europa.eu/en/scdocs/doc/1372.pdf 16 Luangtongkum T, Jeon B, Han J, Plummer P, Logue CM, Zhang Q (2009) Antibiotic resistance in Campylobacter:
Spanish: 16 Luangtongkum T, Jeon B, Han J, Plummer P, Logue CM, Zhang Q (2009) Antibiotic resistance in Campylobacter:
English: Concentrate for oral solution for use in drinking water
Spanish: Concentrado para solución oral para añadir al agua de bebida
English: A study by Haritova et al (2011)11 demonstrated that when E.coli O78/H12 infected chickens (MIC 0.01 µg/ml) were treated with either 10 mg/kg bw or 50 mg/kg bw enrofloxacin for 3 days, both dose
Spanish: En un estudio de Haritova et al.. (2011)11 se demostró que, cuando se trataban los pollos infectados de E. coli O78/H12 (CIM 0,01 µg/ml) con 10 mg/kg de peso corporal o 50 mg/kg de peso corporal de enrofloxacino durante 3 días, ambas dosis controlaban los signos clínicos, pero en el grupo de 50 mg/kg de peso corporal se podía reaislar el patógeno del bazo hasta 25 días después de la infección, mientras que en el grupo de 10 mg/kg de peso corporal se reaisló de los pulmones, el hígado, el corazón y el bazo.
English: Enrofloxacin 100 mg Oral solution Oral
Spanish: Enrofloxacin 100 mg Solución oral
English: Poultry, pigs
Spanish: Aves de corral, cerdos
English: Industrial Veterinaria S.A. Esmeralda, 19.
Spanish: Esmeralda, 19.
English: Pigs, calves, lambs, kids, poultry (chicken and turkey)
Spanish: Cerdos, terneros, corderos, cabritos, aves de corral (pollo y pavo)
English: Chicken, turkey and pigeon
Spanish: Pollo, pavo y paloma
English: Denmark aniMedica GmbH, Im Südfeld 9,
Spanish: Dinamarca aniMedica GmbH, Im Südfeld 9,
English: Calves, pigs, dogs, cats, chickens (broilers), pigeons
Spanish: Terneros, cerdos, perros, gatos, pollos (de engorde), palomas
English: Chickens, pigs and turkeys
Spanish: Pollos, cerdos y pavos
English: 11-500 Giżycko
Spanish: Bialostocka 12, 11-500 Giżycko Polonia
English: Germany Laboratorios Hipra S.A. Avda.
Spanish: Alemania Laboratorios Hipra S.A. Avda.
English: Germany aniMedica GmbH, Im Südfeld 9,
Spanish: Alemania aniMedica GmbH, Im Südfeld 9,
English: Germany Global Vet Health S.L.
Spanish: Alemania Global Vet Health S.L.
English: Poultry, rabbits
Spanish: Pollos, conejos
English: Industrial Veterinaria S.A. Esmeralda, 19
Spanish: Industrial Veterinaria S.A.
English: Lithuania Laboratorios Hipra S.A. Avda.
Spanish: Eslovaquia Laboratorios Hipra S.A. Avda.
English: Romania Global Vet Health S.L.
Spanish: Rumanía Global Vet Health S.L.
English: Universal Farma, S.L., Gran Via Carlos III 98 - 7a, 08028 Barcelona Spain
Spanish: Universal Farma, S.L., Gran Via Carlos III 98 - 7a, 08028 Barcelona España
English: Germany Laboratorios Karizoo S.A., Pol. Ind. La Borda,
Spanish: Alemania Laboratorios Karizoo S.A., Pol. Ind.
English: Chicken (broilers, broiler parent animals, pullets), rabbit
Spanish: Pollos (de engorde, animales parentales de pollos de engorde, pollitos), conejo
English: Chicken, cattle, swine, pigeons, dogs and cats
Spanish: Pollos, ganado vacuno, cerdos, palomas, perros y gatos
English: Chickens (broilers, replacement chickens, broiler breeders) and rabbits
Spanish: Pollos (de engorde, de sustitución, reproductoras de pollos de engorde) y conejos
English: Germany Vetpharma Animal Health S.L.,
Spanish: Alemania Vetpharma Animal Health S.L.,
English: Lithuania Krka d.d.
Spanish: Eslovenia Krka d.d.
English: Pigs, calves, chicken (broilers), turkeys
Spanish: Cerdos, terneros, pollos (de engorde), pavos
English: Cattle (calves), pigs, chicken (broilers), cats, dogs
Spanish: Ganado vacuno (terneros), cerdos, pollos (de engorde), gatos, perros
English: Belgium Laboratorios Karizoo S.A., Pol. Ind. La Borda,
Spanish: Laboratorios Karizoo S.A., Pol. Ind.
English: Romania Bayer Animal Health GmbH, 51368 Leverkusen,
Spanish: Rumanía Bayer Animal Health GmbH, 51368 Leverkusen,
English: Enrofloxacin 100 mg/m Oral solution Oral
Spanish: Enrofloxacin 100 mg/m Solución oral
English: Netherlands Laboratorios Karizoo S.A., Pol. Ind. La Borda,
Spanish: Países Bajos Laboratorios Karizoo S.A., Pol. Ind.
English: Cattle, pig, dog, chicken, turkey and pigeon
Spanish: Ganado vacuno, cerdo, perro, pollo, pavo y paloma
English: Chicken, turkey, pigeons, cattle, swine, dogs and cats
Spanish: Pollos, pavos, palomas, ganado vacuno, cerdos, perros y gatos
English: Netherlands aniMedica GmbH, Im Südfeld 9,
Spanish: Países Bajos aniMedica GmbH, Im Südfeld 9,
English: Oral solution for use in drinking water
Spanish: Solución oral para añadir al agua de bebida
English: Denmark Bayer Animal Health GmbH, 51368 Leverkusen,
Spanish: Dinamarca Bayer Animal Health GmbH, 51368 Leverkusen,
English: EFSA Journal
Spanish: De acuerdo con el informe de síntesis de la EFSA
English: Ireland Universal Farma, S.L., Gran Via Carlos III, 98-7a, 08028 Barcelona
Spanish: Universal Farma, S.L., Gran Via Carlos III, 98-7a, 08028 Barcelona España
English: Netherlands Vetpharma Animal Health S.L.,
Spanish: Países Bajos Vetpharma Animal Health S.L.,
English: Poultry (broilers, replacement chickens, broiler breeders and turkeys)
Spanish: Aves de corral (pollos de engorde, de sustitución, reproductoras de pollos de engorde y pavos)
English: Swine, cattle (calves), broiler chickens, dogs, cats
Spanish: Cerdos, ganado vacuno (terneros), pollos de engorde, perros, gatos
English: Chickens, turkeys and rabbits
Spanish: Pollos, pavos y conejos
English: Chickens Rabbits
Spanish: Pollos Conejos
English: Solution for use in drinking water
Spanish: Solución para añadir al agua de bebida
English: Chicken, cattle, pig, dog, cat and pigeon
Spanish: Pollo, ganado vacuno, cerdo, perro, gato y paloma
English: Broilers, rearing poultry, turkeys
Spanish: Pollos de engorde, aves de corral de cría, pavos
English: Chickens, turkeys, guinea fowl, ducks, pheasant, quails, rabbits
Spanish: Pollos, pavos, pintadas, patos, faisán, codornices, conejos
English: Available online at www.efsa.europa.eu/efsajournal 15 Joint Opinion on antimicrobial resistance focused on zoonotic infections.
Spanish: Joint Opinion on antimicrobial resistance focused on zoonotic infections.
English: Chicken (broilers, replacement chickens, broiler breeders), rabbit
Spanish: Pollo (de engorde, de sustitución, reproductoras de pollos de engorde), conejo
English: Calves, lambs, kids, piglets, poultry, dogs, cats
Spanish: Terneros, corderos, cabritos, cochinillos, aves de corral, perros, gatos
English: Poultry (broilers and broiler breeders)
Spanish: Aves de corral (pollos de engorde y reproductoras de pollos de engorde)
English: Chickens, turkeys, rabbits
Spanish: Pollos, pavos, conejos
English: Chicken broiler
Spanish: Pollo de engorde
English: Chickens (broilers, replacement chickens, broiler breeders) and turkeys
Spanish: Pollos (de engorde, de sustitución, reproductoras de pollos de engorde) y pavos
English: Chicken and turkeys
Spanish: Pollo (de engorde) y pavo
English: Evans MR, Northey G, Sarvotham TS, Rigby CJ, Hopkins AL, Thomas DR (2009) Short-term and medium-term clinical outcomes of quinolone-resistant Campylobacter infection.
Spanish: Future Microbiol Mar;4(2):189-200 17 Evans MR, Northey G, Sarvotham TS, Rigby CJ, Hopkins AL, Thomas DR (2009)
English: Chickens (broilers, broiler breeders, replacement chickens), turkeys
Spanish: Pollos (de engorde, reproductoras de pollos de engorde, de sustitución), pavos
English: Belgium Vetpharma Animal Health S.L.,
Spanish: Eslovaquia Vetpharma Animal Health S.L.,
English: Poultry (broilers)
Spanish: Pollos (de engorde)
English: Solution for oral use
Spanish: INDICACIÓN(ES) DE USO
English: Chicken broilers
Spanish: Aves de corral
English: Entecavir Accord is taken once a day.
Spanish: Entecavir Accord se toma una vez al día.
English: It is not intended to provide practical advice on how to use Entecavir Accord.
Spanish: No está destinado a proporcionar consejos prácticos sobre cómo utilizar Entecavir Accord.
English: The full EPAR for Entecavir Accord can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Spanish: El EPAR completo de Entecavir Accord se puede consultar en la página web de la Agencia: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: This is a summary of the European public assessment report (EPAR) for Entecavir Accord.
Spanish: El presente documento resume el Informe Público Europeo de Evaluación (EPAR) para Entecavir Accord.
English: When treatment is considered appropriate in children, the dose depends on their body weight.
Spanish: Cuando se considera adecuado el tratamiento en niños, la dosis dependerá de su peso corporal.
English: The European Medicines Agency concluded that, in accordance with EU requirements, Entecavir Accord has been shown to have comparable quality and to be bioequivalent to Baraclude.
Spanish: La Agencia Europa de Medicamentos concluyó que, de conformidad con los requisitos de la UE, Entecavir Accord ha demostrado tener una calidad comparable y ser bioequivalente a Baraclude.
English: It can also be considered for children aged from 2 to 18 years but only in those with compensated liver disease.
Spanish: También puede considerarse su uso en niños y adolescentes de 2 a 18 años, pero solo si presentan enfermedad hepática compensada.
English: Other information about Entecavir Accord
Spanish: Otras informaciones sobre Entecavir Accord
English: Because Entecavir Accord is a generic medicine and is bioequivalent to the reference medicine, its benefits and risks are taken as being the same as the reference medicine's.
Spanish: Dado que Entecavir Accord es un medicamento genérico y es bioequivalente al medicamento de referencia, sus beneficios y riesgos son los mismos que los del medicamento de referencia.
English: Entecavir Accord can only be obtained with a prescription and is available as tablets (0.5 mg and 1 mg).
Spanish: Entecavir Accord solo se podrá dispensar con receta médica y está disponible en comprimidos (0,5 mg y 1 mg).
English: What measures are being taken to ensure the safe and effective use of Entecavir Accord?
Spanish: ¿Qué medidas se han adoptado para garantizar un uso seguro y eficaz de Entecavir Accord?
English: Treatment with Entecavir Accord should be started by a doctor with experience in the management of chronic hepatitis B.
Spanish: El tratamiento con Entecavir Accord debe ser iniciado por un médico con experiencia en el tratamiento de la hepatitis B crónica.
English: What is Entecavir Accord and what is it used for?
Spanish: ¿Qué es Entecavir Accord y para qué se utiliza?
English: Studies on the benefits and risks of the active substance in the approved uses have already been carried out with the reference medicine, Baraclude, and do not need to be repeated for Entecavir Accord.
Spanish: Se han realizado estudios sobre los beneficios y los riesgos del principio activo en los usos aprobados con el medicamento de referencia, Baraclude, y no es necesario repetirlos con Entecavir Accord.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Entecavir Accord have been included in the summary of product characteristics and the package leaflet.
Spanish: Las recomendaciones y precauciones que deben seguir los profesionales sanitarios y los pacientes para un uso seguro y eficaz de Entecavir Accord se han incluido en la Ficha Técnica o Resumen de las Características del Producto y el Prospecto.
English: For adults with compensated liver disease, the dose depends on whether or not the patient has been previously treated with a medicine in the same group as Entecavir Accord (a nucleoside analogue, such as lamivudine).
Spanish: En adultos con enfermedad hepática compensada, la dosis varía en función de si el paciente ha sido tratado anteriormente o no con un medicamento del mismo grupo que Entecavir Accord (un análogo de nucleósidos, como la lamivudina).
English: Children weighing 32.6 kg and above can be given the 0.5 mg tablets, while an oral solution of entecavir may be available for children weighing less than 32.6 kg. For further information, see the package leaflet.
Spanish: Los niños con un peso de 32,6 kg o mayor podrán recibir los comprimidos de 0,5 mg, mientras que existe una solución oral de entecavir para los niños que pesen menos de 32,6 kg. Para más información, consulte el prospecto.
English: The active substance in Entecavir Accord, entecavir, is an antiviral belonging to the class of the nucleoside analogues.
Spanish: El principio activo de Entecavir Accord, el entecavir, es un antiviral que pertenece al grupo de los análogos de nucleósidos.
English: Entecavir interferes with the action of a viral enzyme, DNA polymerase, which is involved in the formation of viral DNA.
Spanish: El entecavir interfiere en la acción de una enzima viral, la ADN-polimerasa, que interviene en la formación del ADN viral.
English: For more information about treatment with Entecavir Accord, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Spanish: Para más información sobre el tratamiento con Entecavir Accord, lea el prospecto (también incluido en el EPAR) o consulte a su médico o farmacéutico.
English: Entecavir Accord is a medicine used to treat chronic (long-term) hepatitis B (an infectious disease of the liver, caused by the hepatitis B virus).
Spanish: Entecavir Accord es un medicamento que se utiliza para el tratamiento de la hepatitis B (una enfermedad infecciosa que afecta al hígado, causada por el virus de la hepatitis B) crónica (de larga duración).
English: This means that Entecavir Accord contains the same active substance and works in the same way as a ‘reference medicine' already authorised in the European Union (EU) called Baraclude.
Spanish: Entecavir Accord contiene el principio activo entecavir y es un «medicamento genérico», es decir, contiene el mismo principio activo y actúa de la misma forma que un «medicamento de referencia» ya autorizado en la Unión Europea (UE) llamado Baraclude.
English: For practical information about using Entecavir Accord, patients should read the package leaflet or contact their doctor or pharmacist.
Spanish: Para más información sobre el tratamiento con Entecavir Accord, el paciente debe leer el prospecto o consultar a su médico o farmacéutico.
English: Why is Entecavir Accord approved?
Spanish: ¿Por qué se ha aprobado Entecavir Accord?
English: What are the benefits and risks of Entecavir Accord?
Spanish: ¿Qué beneficios ha demostrado tener y cuál es el riesgo asociado a Entecavir Accord?
English: Therefore, the Agency's view was that, as for Baraclude, the benefit outweighs the identified risk.
Spanish: Por tanto, la Agencia consideró que, al igual que en el caso de Baraclude, los beneficios son mayores que los riesgos identificados y recomendó autorizar su uso en la UE.
English: As for every medicine, the company provided studies on the quality of Entecavir Accord.
Spanish: La compañía presentó estudios sobre la calidad de Entecavir Accord, como se hace con todos los medicamentos.
English: How is Entecavir Accord used?
Spanish: ¿Cómo se usa Entecavir Accord?
English: How does Entecavir Accord work?
Spanish: ¿Cómo actúa Entecavir Accord?
English: How has Entecavir Accord been studied?
Spanish: ¿Qué tipo de estudios se han realizado con Entecavir Accord?
English: Exelon can be used with food, drink and alcohol.
Spanish: Exelon se puede utilizar con alimentos, bebida y alcohol.
English: Date of first authorisation: 12 May 1998 Date of latest renewal: 20 May 2008
Spanish: Fecha de la primera autorización: 12/mayo/1998 Fecha de la última renovación: 20/mayo/2008
English: Other medicines and Exelon
Spanish: Otros medicamentos y Exelon
English: • Take Exelon twice a day, in the morning and evening, with food.
Spanish: • Tome Exelon dos veces al día (por la mañana y por la noche), con las comidas.
English: If you accidentally take more Exelon than you should, inform your doctor.
Spanish: Si accidentalmente toma más Exelon del que debiera, informe a su médico.
English: If you find you have forgotten to take your dose of Exelon, wait and take the next dose at the usual time.
Spanish: Si olvida su dosis de Exelon, espere y tome la siguiente dosis a la hora habitual.
English: Your doctor will tell you what dose of Exelon to take.
Spanish: Su médico le indicará que dosis de Exelon debe tomar.
English: For patients starting treatment for the first time and for patients restarting Exelon after treatment interruption, please begin with the second picture.
Spanish: Los pacientes que inician el tratamiento por primera vez y para pacientes que reinician el tratmiento con Exelon después de la interrupción del tratamiento,deben empezar por la segunda figura.
English: What Exelon is and what it is used for
Spanish: Qué es Exelon y para qué se utiliza
English: The MAH shall ensure that, following discussions and agreement with the National Competent Authorities in each Member State where Exelon patch is marketed, all physicians who are expected to prescribe Exelon patch are provided with an information pack containing the following elements:
Spanish: El TAC debe asegurar, después de comentarlo y acordarlo con las Autoridades Nacionales Competentes en cada Estado Miembro donde se comercialice Exelon parches, que los médicos que se espera que prescriban Exelon parches sean provistos de un paquete informativo que contenga los siguientes elementos:
English: Can you wear your Exelon transdermal patch when you are bathing, swimming, or in the sun?
Spanish: ¿Puede llevar su Exelon parche transdérmico cuando se bañe, nade o se exponga al sol?
English: However, Exelon may be used in this patient population and close monitoring is necessary.
Spanish: Sin embargo, Exelon puede utilizarse en esta población de pacientes siendo necesaria una monitorización minuciosa.
English: • Tell your caregiver that you are taking Exelon.
Spanish: • Informe a su cuidador que está tomando Exelon.
English: Gently pull at one edge of the patch to remove it slowly from the skin.
Spanish: Tire suavemente de uno de los bordes del parche para despegarlo lentamente de la piel.
English: Back
Spanish: Atrás
English: If you stop using Exelon Tell your doctor or pharmacist if you stop using the patch.
Spanish: Si interrumpe el tratamiento con Exelon Informe a su médico o farmacéutico si deja de utilizar los parches.
English: Absorption of rivastigmine from Exelon transdermal patches is slow.
Spanish: La absorción de rivastigmina a partir de Exelon parches transdérmicos es lenta.
English: Exelon contains sodium benzoate
Spanish: Exelon contiene benzoato sódico
English: It was rated as severe in ≤2.2% of patients in these studies and in ≤3.7% of patients treated with Exelon transdermal patches in a Japanese study.
Spanish: En estos ensayos se consideró como grave en ≤2,2% de los pacientes y en ≤3,7% de los pacientes tratados con Exelon parches transdérmicos en un ensayo Japonés.
English: However, these events did not occur at a higher frequency with Exelon 13.3 mg/24 h transdermal patches than with placebo.
Spanish: Sin embargo, estos efectos no se produjeron con una mayor frecuencia con Exelon 13,3 mg/24 h parches transdérmicos que con placebo.
English: At least 4 points improvement on ADASCog with no worsening on CIBIC-Plus and PDS *p<0.05, **p<0.01, ***p<0.001
Spanish: Mejoría de al menos 4 puntos en el ADAS-Cog sin empeoramiento en el CIBIC-Plus y en la PDS *p<0,05, **p<0,01, ***p<0,001
English: If you have not taken Exelon for more than three days, do not take the next dose until you have talked to your doctor.
Spanish: Si no ha tomado Exelon durante más de tres días, no tome la próxima dosis hasta que lo haya consultado a su médico.
English: Misuse of the medicinal product and dosing errors with Exelon transdermal patch have resulted in serious adverse reactions; some cases have required hospitalisation, and rarely led to death (see section 4.9).
Spanish: El mal uso del medicamento y errores en la dosificación con Exelon parche transdérmico han llevado a reacciones adversas graves, algunos casos han requerido hospitalización, y raramento pueden tener consecuencias fatales (ver sección 4.9).
English: Patients and their caregivers must be instructed on important administration instructions for Exelon transdermal patch (see section 4.2).
Spanish: Se debe instruir a los pacientes y a sus cuidadores de las importantes instrucciones de administración de Exelon parches transdérmicos (ver sección 4.2).
English: Exelon should not be given at the same time as other medicines with similar effects to Exelon.
Spanish: Exelon no deberá administrarse al mismo tiempo que otros medicamentos con efectos similares a los de Exelon.
English: Exelon is used for the treatment of adult patients with mild to moderately severe Alzheimer's dementia, a progressive brain disorder that gradually affects memory, intellectual ability and behaviour.
Spanish: Exelon se utiliza para el tratamiento de pacientes adultos con demencia de Alzheimer de leve a moderadamente grave, un trastorno progresivo del cerebro que afecta gradualmente a la memoria, capacidad intelectual y el comportamiento.
English: This may indicate a potential for Exelon transdermal patches to induce mild erythema in patients.
Spanish: Esto podría sugerir un potencial de Exelon parches transdérmicos para inducir eritemas leves en pacientes.
English: Like all medicines, Exelon transdermal patches can cause side effects, although not everybody gets them.
Spanish: Al igual que todos los medicamentos, Exelon parches transdérmicos puede producir efectos adversos, aunque no todas las personas los sufran.
English: • Only wear one Exelon patch at a time and replace the patch with a new one after 24 hours.
Spanish: • Lleve sólo un Exelon parche al mismo tiempo y sustituya el parche por otro nuevo a las
English: Exelon patches are thin, opaque, plastic patches that stick to the skin.
Spanish: Los parches de Exelon son de plástico fino y opaco y se pegan a la piel.
English: Contact with the eyes should be avoided after handling Exelon transdermal patches (see section 5.3).
Spanish: Debe evitarse el contacto con los ojos tras manipular Exelon parches transdérmicos (ver sección 5.3).
English: If you use more Exelon than you should
Spanish: Si usa más Exelon del que debe
English: Exelon transdermal patches may cause fainting or severe confusion.
Spanish: Exelon parches transdérmicos puede causar mareos y confusión grave.
English: One of the inactive ingredients in Exelon oral solution is sodium benzoate.
Spanish: Uno de los ingredientes inactivos de Exelon solución oral es el benzoato sódico.