FrancophonIA/ELRC3.0 huggingface dataset:
English: Hepatic impairment: Moderate liver disease (Child Pugh Class B) affected the pharmacokinetics of duloxetine.
Croatian: Oštećenje jetrene funkcije: umjerena bolest jetre (Child Pugh stadij B) utjecala je na farmakokinetiku duloksetina.
English: Although YENTREVE is not indicated for the treatment of depression, its active ingredient (duloxetine) also exists as an antidepressant medicinal product.
Croatian: Iako YENTREVE nije indiciran za liječenje depresije, njegov djelatni sastojak (duloksetin) također se koristi kao antidepresivni lijek.
English: - are taking other medicines containing duloxetine (see ‘Other medicines and YENTREVE')
Croatian: - ako uzimate druge lijekove koji sadrže duloksetin (pogledajte „Drugi lijekovi i YENTREVE“).
English: However, limited data are available to support the efficacy of YENTREVE 20 mg twice daily.
Croatian: Međutim, postoje ograničeni podaci koji podupiru djelotvornost lijeka YENTREVE u dozi od 20 mg dvaput dnevno.
English: Monoamine oxidase inhibitors (MAOIs): You should not take YENTREVE if you are taking or have recently taken (within the last 14 days) an antidepressant medicine called a monoamine oxidase inhibitor (MAOI).
Croatian: Inhibitore monoamino-oksidaze (MAOI): ne smijete uzimati YENTREVE ako uzimate ili ste nedavno (unutar zadnjih 14 dana) uzimali antidepresivni lijek koji se zove inhibitor monoamino oksidaze (MAOI).
English: If concomitant treatment with duloxetine and other serotonergic agents that may affect the serotonergic and/or dopaminergic neurotransmitter systems in clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.
Croatian: Ako je istodobno liječenje duloksetinom i drugim serotoninergičkim lijekovima koji mogu utjecati na sustave serotoninergičke i/ili dopaminergičke neurotransmisije klinički neophodno, preporučuje se strogi nadzor bolesnika, osobito pri uvođenju lijeka i povećanju doze.
English: • grinding or clenching the teeth, feeling disorientated, lack of motivation, difficulty or failure to experience orgasm, unusual dreams
Croatian: • škripanje ili stiskanje zubima, osjećaj dezorijentiranosti, nedostatak motivacije, teškoće ili nemogućnost postizanja orgazma, neobični snovi
English: In animal studies, increased levels of 5-HT and NE in the sacral spinal cord, lead to increased urethral tone via enhanced pudendal nerve stimulation to the urethral striated sphincter muscle only during the storage phase of the micturition cycle.
Croatian: U istraživanjima na životinjama povišene razine 5-HT i NE u sakralnom dijelu kralježnične moždine dovele su do povećanog tonusa uretre pojačanom stimulacijom stidnog živca na poprečnoprugasti mišićni sfinkter uretre samo tijekom razdoblja pohrane u ciklusu mokrenja.
English: Studies in animals have shown reproductive toxicity at systemic exposure levels (AUC) of duloxetine lower than the maximum clinical exposure (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su reproduktivnu toksičnost pri razinama sistemske izloženosti (AUC) duloksetinu manjima od maksimalne kliničke izloženosti (vidjeti dio 5.3).
English: Cases of hypertensive crisis have been reported with duloxetine, especially in patients with pre-existing hypertension.
Croatian: Prijavljeni su slučajevi hipertenzivne krize kod primjene duloksetina, osobito u bolesnica s već postojećom hipertenzijom.
English: Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant
Croatian: Informacije iz kliničkih ispitivanja pokazale su povećan rizik od samoubilačkog ponašanja u odraslih koji su mlađi od 25 godina, a zbog psihijatrijskih stanja su liječeni antidepresivom.
English: If, based on clinical need, a decision to treat is nevertheless taken, the patient should be carefully monitored for the appearance of suicidal symptoms.
Croatian: ipak donese odluka o liječenju, bolesnicu treba pažljivo pratiti kako bi se uočila moguća pojava suicidalnih simptoma.
English: YENTREVE should be used with caution in patients with a history of mania or a diagnosis of bipolar disorder, and/or seizures.
Croatian: YENTREVE se mora s oprezom primjenjivati kod bolesnica s manijom u anamnezi ili s dijagnozom bipolarnog poremećaja i/ili napadaja.
English: Caution is required in patients at increased risk for hyponatraemia, such as elderly, cirrhotic, or dehydrated patients or patients treated with diuretics.
Croatian: Oprez je nužan u bolesnica s povećanim rizikom od hiponatrijemije, poput starijih osoba, bolesnica s cirozom, dehidriranih bolesnica ili bolesnica koje se liječe diureticima.
English: Anticoagulants and antiplatelet agents: Caution should be exercised when duloxetine is combined with oral anticoagulants or antiplatelet agents due to a potential increased risk of bleeding attributable to a pharmacodynamic interaction.
Croatian: Antikoagulantni i antitrombocitni lijekovi: potreban je oprez kada se duloksetin kombinira s peroralnim antikoagulantnim ili antitrombocitnim lijekovima zbog mogućeg povećanog rizika od krvarenja koji se pripisuje farmakodinamičkoj interakciji.
English: • abnormal vaginal bleeding, menopausal symptoms
Croatian: • nenormalno vaginalno krvarenje, simptomi menopauze
English: • feeling nervous, difficulty concentrating, changes in sense of taste, poor sleep quality
Croatian: • osjećaj nervoze, teškoće s koncentracijom, promjene osjeta okusa, loša kvaliteta sna
English: Inducers of CYP1A2: Population pharmacokinetic studies analyses have shown that smokers have almost 50% lower plasma concentrations of duloxetine compared with non-smokers.
Croatian: Induktori CYP1A2: populacijske farmakokinetičke analize ispitivanja pokazale su da su u pušača koncentracije duloksetina u plazmi gotovo 50% niže u usporedbi s nepušačima.
English: Your doctor may decide to start your treatment with 20 mg twice a day for two weeks before increasing the dose to 40 mg twice a day.
Croatian: Liječnik će možda odlučiti započeti liječenje dozom od 20 mg dvaput na dan tijekom dva tjedna prije povišenja doze na 40 mg dvaput na dan.
English: When duloxetine was administered at a dose of 60 mg twice daily with a single dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold.
Croatian: Kada je duloksetin u dozi od 60 mg dvaput dnevno primijenjen s jednokratnom dozom dezipramina, supstratom CYP2D6, AUC dezipramina se povećao 3 puta.
English: Incontinence Episode Frequency: In all four studies the duloxetine-treated group had a 50% or greater median decrease in IEF compared with 33% in the placebo-treated group.
Croatian: Učestalost epizoda inkontinencije: u sva je četiri ispitivanja skupina liječena duloksetinom imala medijan smanjenja UEI-a od 50% ili više, u usporedbi sa 33% u skupini koja je uzimala placebo.
English: Your doctor will tell you if you should be taking YENTREVE.
Croatian: Liječnik će Vam reći smijete li uzimati YENTREVE.
English: Elimination: The elimination half-life of duloxetine ranges from 8 to 17 hours (mean of 12 hours).
Croatian: Eliminacija: poluvijek eliminacije duloksetina kreće se u rasponu od 8 do 17 sati (srednja vrijednost
English: Using a global improvement scale (PGI), significantly more women using duloxetine considered their symptoms of stress incontinence to be improved with treatment compared with women using placebo (64.6% versus 50.1%, p<0.001).
Croatian: Prema ljestvici ukupnog poboljšanja (PGI) značajno veći broj žena liječenih duloksetinom nego onih koje su primale placebo smatralo je da im je liječenje ublažilo njihove simptome (64,6% naspram 50,1%, p<0,001).
English: Supra-ventricular arrhythmia, mainly atrial fibrillation6
Croatian: Srčani poremećaji palpitacije tahikardija supraventrikularna aritmija, uglavnom fibrilacija atrija6
English: Hyponatraemia has been reported when administering YENTREVE, including cases with serum sodium lower than 110 mmol/l.
Croatian: Prijavljeni su slučajevi hiponatrijemije kod primjene lijeka YENTREVE, uključujući slučajeve sa serumskim natrijem nižim od 110 mmol/l.
English: In a clinical trial, adverse events seen on abrupt treatment discontinuation occurred in approximately 44% of patients treated with YENTREVE and 24% of patients taking placebo.
Croatian: U kliničkom ispitivanju štetni događaji primijećeni nakon naglog prekida liječenja pojavili su se u približno 44% bolesnica liječenih lijekom YENTREVE i u 24% bolesnica koje su uzimale placebo.
English: The amount of duloxetine in breast milk is approximately 7 µg/day while on 40 mg twice daily dosing.
Croatian: Količina duloksetina u majčinom mlijeku je približno 7 µg/dan dok majke uzimaju dozu od 40 mg dva puta dnevno.
English: YENTREVE is a hard gastro-resistant capsule.
Croatian: YENTREVE je tvrda želučanootporna kapsula.
English: Duloxetine is used under different trademarks in several indications (treatment of diabetic neuropathic pain, major depressive disorder, generalised anxiety disorder and stress urinary incontinence).
Croatian: Duloksetin je prisutan na tržištu pod različitim zaštićenim imenima u nekoliko indikacija (liječenje boli kod dijabetičke neuropatije, velikog depresivnog poremećaja, generaliziranog anksioznog poremećaja i stresne urinarne inkontinencije).
English: A meta-analysis of placebocontrolled clinical trials of antidepressant medicinal products in psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Croatian: Metaanaliza placebom kontroliranih kliničkih ispitivanja antidepresivnih lijekova u liječenju psihijatrijskih poremećaja pokazala je povećan rizik od suicidalnog ponašanja kod primjene antidepresiva u usporedbi s placebom u bolesnica mlađih od 25 godina.
English: Observational data have provided evidence of an increased risk (less than 2-fold) of postpartum haemorrhage following duloxetine exposure within the month prior to birth.
Croatian: Opservacijski podaci pružili su dokaze (manje od dvostruko) povećanog rizika od poslijeporođajnog krvarenja nakon izlaganja duloksetinu blizu vremena poroda.
English: Other medicines and YENTREVE
Croatian: Drugi lijekovi i YENTREVE
English: Also, you need to wait at least 5 days after you stop taking YENTREVE before you take a MAOI.
Croatian: Također, nakon što ste prekinuli uzimati YENTREVE, morate pričekati najmanje 5 dana prije nego uzmete MAOI.
English: Duloxetine is detected in breast milk, and steady-state concentrations in breast milk are about one-fourth those in plasma.
Croatian: Duloksetin je pronađen u majčinom mlijeku, a koncentracije u majčinom mlijeku u stanju dinamičke ravnoteže bile su oko jednu četvrtinu od onih u plazmi.
English: The data analysis of four 12-week, placebo-controlled clinical trials in patients with SUI, including 958 duloxetine-treated and 955 placebo-treated patients, showed that the onset of the reported adverse events typically occurred in the first week of therapy.
Croatian: Analiza podataka iz četiri 12-tjedna placebom kontrolirana klinička ispitivanja u bolesnica sa stresnom urinarnom inkontinencijom, uključujući 958 bolesnica liječenih duloksetinom i 955 bolesnica koje su uzimale placebo, pokazala je da se prijavljene nuspojave obično javljaju u prvom tjednu liječenja.
English: Discontinuation of duloxetine (particularly when abrupt) commonly leads to withdrawal symptoms.
Croatian: Prekid primjene duloksetina (osobito nagli prekid) često dovodi do pojave simptoma prekida primjene lijeka.
English: Name and address of the manufacturer(s) responsible for batch release
Croatian: Naziv i adresa proizvođača odgovornog (ih) za puštanje serije lijeka u promet
English: Monoamine oxidase inhibitors (MAOIs): Due to the risk of serotonin syndrome, duloxetine should not be used in combination with non-selective irreversible monoamine oxidase inhibitors (MAOIs), or within at least 14 days of discontinuing treatment with an MAOI.
Croatian: Inhibitori monoaminooksidaze (MAOI): zbog rizika od serotoninskog sindroma duloksetin se ne smije primjenjivati u kombinaciji s neselektivnim ireverzibilnim inhibitorima monoaminooksidaze (MAOI) ili unutar najmanje 14 dana nakon prekida liječenja nekim od MAOI.
English: Hyponatraemia may be due to a syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Croatian: Hiponatrijemija može biti uzrokovana sindromom neprikladnog izlučivanja antidiuretskog hormona (SIADH; engl. syndrome of inappropriate antidiuretic hormone secretion).
English: • chest pain, feeling cold, thirst, feeling hot
Croatian: • bol u prsima, osjećaj hladnoće, žeđ, osjećaj vrućine
English: In the 12 week acute phase of three clinical trials of duloxetine in patients with diabetic neuropathic pain, small but statistically significant increases in fasting blood glucose were observed in duloxetinetreated patients.
Croatian: U 12-tjednoj akutnoj fazi triju kliničkih ispitivanja duloksetina u bolesnica s boli kod dijabetičke neuropatije primijećena su mala, ali statistički značajna povećanja glukoze u krvi natašte u bolesnica liječenih duloksetinom.
English: Fluvoxamine (100 mg once daily), a potent inhibitor of CYP1A2, decreased the apparent plasma clearance of duloxetine by about 77% and increased AUC0-t 6-fold.
Croatian: Fluvoksamin (100 mg jednom dnevno), potentni inhibitor CYP1A2, smanjio je prividni klirens duloksetina iz plazme za oko 77% i 6 puta povećao AUCo-t.
English: You must wait at least 14 days after you have stopped taking an MAOI before you can take YENTREVE.
Croatian: Nakon što ste prekinuli uzimati MAOI, morate pričekati najmanje 14 dana prije nego možete uzeti YENTREVE.
English: Each capsule of YENTREVE contains pellets of duloxetine hydrochloride with a covering to protect them from stomach acid.
Croatian: Jedna YENTREVE kapsula sadrži granule duloksetinklorida s ovojnicom koja ih štiti od želučane kiseline.
English: SIADH6
Croatian: hiponatrijemija SIADH6
English: Stress urinary incontinence is a medical condition in which patients have accidental loss or leakage of urine during physical exertion or activities such as laughing, coughing, sneezing, lifting, or exercise.
Croatian: Stresna urinarna inkontinencija je stanje kod kojeg dolazi do nevoljnog ispuštanja mokraće tijekom fizičkog naprezanja ili aktivnosti poput smijanja, kašljanja, kihanja, podizanja ili tjelovježbe.
English: As with other serotonergic medicinal products, discontinuation symptoms may occur in the neonate after maternal duloxetine use near term.
Croatian: Kao i kod drugih serotoninergičkih lijekova, moguća je pojava simptoma prekida primjene lijeka u novorođenčeta ako je majka uzimala duloksetin u vrijeme blizu porođaja.
English: However, concomitant administration of duloxetine with warfarin under steady state conditions, in healthy volunteers, as part of a clinical pharmacology study, did not result in a clinically significant change in INR from baseline or in the pharmacokinetics of R- or S-warfarin.
Croatian: istodobna primjena duloksetina s varfarinom u stanju dinamičke ravnoteže u zdravih dobrovoljaca, kao dio kliničkog farmakološkog ispitivanja, nije rezultirala klinički značajnom promjenom INR-a u odnosu na početne vrijednosti, kao ni farmakokinetike
English: Medicines that cause sleepiness: These include medicines prescribed by your doctor including benzodiazepines, strong painkillers, antipsychotics, phenobarbital and sedative antihistamines.
Croatian: Lijekovi koji uzrokuju pospanost: to uključuje lijekove koje Vam je propisao liječnik, uključujući benzodiazepine, jake lijekove protiv bolova, antipsihotike, fenobarbital i sedativne antihistaminike.
English: Duloxetine has been associated with an increase in blood pressure and clinically significant hypertension in some patients.
Croatian: U nekih je bolesnica duloksetin povezan s povišenjem krvnog tlaka i klinički značajnom hipertenzijom.
English: Inhibitors of CYP1A2: Because CYP1A2 is involved in duloxetine metabolism, concomitant use of YENTREVE with potent inhibitors of CYP1A2 is likely to result in higher concentrations of duloxetine.
Croatian: Inhibitori CYP1A2: budući da je CYP1A2 uključen u metabolizam duloksetina, istodobna primjena lijeka YENTREVE s potentnim inhibitorima CYP1A2 vjerojatno će rezultirati povišenim koncentracijama duloksetina.
English: In the extension phase of these studies, which lasted up to 52 weeks, there was an increase in HbA1c in both the duloxetine and routine care groups, but the mean increase was 0.3% greater in the duloxetinetreated group.
Croatian: U produženoj fazi tih ispitivanja, koje je trajalo do 52 tjedna, HbA1c se povećao i u skupini liječenoj duloksetinom i u skupinama bolesnica na standardnom liječenju, ali je srednja vrijednost bila za 0,3% veća u skupini liječenoj duloksetinom.
English: It is therefore advised that duloxetine should be gradually tapered when discontinuing treatment over a period of no less than 2 weeks, according to the patient's needs (see section 4.2).
Croatian: Stoga se savjetuje da se kod prekida liječenja duloksetinom doza postupno smanjuje tijekom razdoblja od ne manje od 2 tjedna, sukladno potrebama bolesnica (vidjeti dio 4.2).
English: The use of duloxetine has been associated with the development of akathisia, characterised by a subjectively unpleasant or distressing restlessness and need to move often accompanied by an inability to sit or stand still.
Croatian: Akatizija/psihomotorni nemir Primjena duloksetina povezana je s razvojem akatizije koju karakterizira subjektivno neugodan ili uznemirujući nemir i potreba za kretanjem, često praćena nesposobnošću mirnog sjedenja ili stajanja.
English: Duloxetine should be used with caution in patients whose conditions could be compromised by an increased heart rate or by an increase in blood pressure.
Croatian: Duloksetin se mora primjenjivati s oprezom u bolesnica čije stanja mogu biti kompromitirana ubrzanjem srčane frekvencije ili povišenjem krvnog tlaka.
English: The main ingredient of YENTREVE, duloxetine, is used in other medicines for other conditions:
Croatian: Duloksetin, glavni sastojak lijeka YENTREVE, nalazi se i u nekim drugim lijekovima koji se koriste za liječenje drugih stanja:
English: Duloxetine is extensively metabolised by oxidative enzymes (CYP1A2 and the polymorphic CYP2D6), followed by conjugation.
Croatian: Duloksetin se opsežno metabolizira oksidacijskim enzimima (CYP1A2 i polimorfnim CYP2D6) nakon čega se konjugira.
English: Some patients may benefit from starting treatment at a dose of 20 mg twice daily for two weeks before increasing to the recommended dose of 40 mg twice daily.
Croatian: Nekim bi bolesnicama moglo koristiti ako se liječenje započne dozom od 20 mg dvaput na dan tijekom dva tjedna prije povećanja doze na preporučenu dozu od 40 mg dvaput dnevno.
English: Cases of liver injury, including severe elevations of liver enzymes (>10 times upper limit of normal), hepatitis and jaundice have been reported with duloxetine (see section 4.8).
Croatian: Kod primjene duloksetina prijavljeni su slučajevi oštećenja jetre, uključujući velika povišenja jetrenih enzima (> 10 puta iznad gornje granice normale), hepatitis i žutica (vidjeti dio 4.8).
English: Generally these symptoms are self-limiting and usually resolve within 2 weeks, though in some individuals they may be prolonged (2-3 months or more).
Croatian: tjedna, iako kod nekih osoba mogu dulje trajati (2-3 mjeseca ili dulje).
English: YENTREVE should not be used in combination with CYP1A2 inhibitors, like fluvoxamine, ciprofloxacin or enoxacin since the combination results in elevated plasma concentrations of duloxetine (see section 4.5).
Croatian: YENTREVE se ne smije primjenjivati u kombinaciji s inhibitorima CYP1A2, poput fluvoksamina, ciprofloksacina ili enoksacina jer ta kombinacija rezultira povišenim koncentracijama duloksetina u plazmi (vidjeti dio 4.5).
English: Withdrawal symptoms when treatment is discontinued are common, particularly if discontinuation is abrupt (see section 4.8).
Croatian: Simptomi koji se javljaju pri prekidu liječenja su česti, naročito ako se liječenje prekine naglo (vidjeti dio 4.8).
English: Therefore YENTREVE should not be administered in combination with potent inhibitors of CYP1A2 like fluvoxamine (see section 4.3).
Croatian: Stoga se YENTREVE ne smije primjenjivati u kombinaciji s potentnim inhibitorima CYP1A2 poput fluvoksamina (vidjeti dio 4.3).
English: Serotonergic agents: In rare cases, serotonin syndrome has been reported in patients using SSRIs/SNRIs concomitantly with serotonergic agents.
Croatian: Serotoninergički lijekovi: u rijetkim je slučajevima prijavljen serotoninski sindrom u bolesnica koje su uzimale SSRI-je/SNRI-je istodobno sa serotoninergičkim lijekovima.
English: YENTREVE is indicated for women for the treatment of moderate to severe Stress Urinary Incontinence (SUI).
Croatian: YENTREVE je indiciran u žena za liječenje umjerene do teške stresne urinarne inkontinencije (SUI).
English: Compared with healthy subjects, the apparent plasma clearance of duloxetine was 79% lower, the apparent terminal half-life was 2.3 times longer, and the AUC was 3.7 times higher in patients with moderate liver disease.
Croatian: U usporedbi sa zdravim ispitanicama, u bolesnica s umjereno teškom bolešću jetre je prividni klirens duloksetina iz plazme bio je 79% niži, prividan terminalni poluvijek bio je 2,3 puta dulji, a AUC je bio 3,7 puta veći.
English: The pharmacokinetics of duloxetine in patients who are poor metabolisers with respect to CYP2D6 has not been specifically investigated.
Croatian: Farmakokinetika duloksetina u bolesnica koje su slabi metabolizatori s obzirom na CYP2D6 nije posebno ispitivana.
English: Studies in juvenile rats reveal transient effects on neurobehaviour, as well as significantly decreased body weight and food consumption; hepatic enzyme induction; and hepatocellular vacuolation at 45 mg/kg/day.
Croatian: Ispitivanja u mladih štakora ukazala su na prolazne učinke na neurološki status, ali i značajno smanjenje tjelesne težine i unosa hrane, indukciju jetrenih enzima te vakuolizaciju jetrenih stanica pri dozi od 45 mg/kg na dan.
English: • inflammation of the liver that may cause abdominal pain and yellowing of the skin or whites of the eyes
Croatian: • upala jetre koja može uzrokovati bol u trbuhu i žutilo kože ili bjeloočnica
English: Table 1 gives the adverse reactions observed from spontaneous reporting and in placebo-controlled clinical trials.
Croatian: U Tablici 1 prikazane su nuspojave opažene iz spontanih prijava i u placebom kontroliranim kliničkim ispitivanjima.
English: Female rats receiving duloxetine before and during mating and early pregnancy had a decrease in maternal food consumption and body weight, oestrous cycle disruption, decreased live birth indices and progeny survival, and progeny growth retardation at systemic exposure levels estimated to be at the most at maximum clinical exposure (AUC).
Croatian: Ženke štakora koje su primale duloksetin prije i tijekom parenja i rane trudnoće imale su smanjenje unosa hrane i tjelesne težine, prekid estrusnog ciklusa, smanjen indeks živookoćene mladunčadi, smanjeno preživljenje mladunčadi te zaostajanje u rastu mladunčadi pri razinama sistemske izloženosti koja je odgovarala maksimalnoj kliničkoj izloženosti (AUC).
English: Based on the half-life of duloxetine, at least 5 days should be allowed after stopping YENTREVE before starting an MAOI (see section
Croatian: S obzirom na poluvijek duloksetina, mora proći najmanje 5 dana nakon prestanka primjene lijeka YENTREVE prije početka liječenja MAOI-ma (vidjeti dio 4.3).
English: There was also a small increase in fasting blood glucose and in total cholesterol in duloxetine-treated patients while those laboratory tests showed a slight decrease in the routine care group.
Croatian: Glukoza u krvi natašte i ukupni kolesterol bili su malo povećani u bolesnica liječenih duloksetinom, dok su laboratorijske pretrage pokazale malo sniženje tih parametara u skupini bolesnica na standardnom liječenju.
English: Medicinal products metabolised by CYP2D6: Duloxetine is a moderate inhibitor of CYP2D6.
Croatian: Lijekovi koji se metaboliziraju pomoću CYP2D6: duloksetin je umjereni inhibitor CYP2D6.