FrancophonIA/ELRC3.0 huggingface dataset:
English: Most haematologic adverse reactions were reported commonly or very commonly in both indications (Tables 4 and 5); the frequency of grade 3-4 laboratory findings is presented after each table.
Slovenian: O večini hematoloških neželenih učinkov so poročali pogosto ali zelo pogosto pri obeh indikacijah (razpredelnici 4 in 5); pogostost rezultatov laboratorijskih preiskav stopnje 3 do 4 je predstavljena pod vsako razpredelnico.
English: Plasma concentrations increase in a dose-related manner.
Slovenian: Koncentracije v plazmi se višajo sorazmerno z odmerkom.
English: Doserelated reductions in leukocytes and platelets appear to be sensitive indicators of toxicity.
Slovenian: Kaže, da so z odmerkom povezana zmanjšanja levkocitov in trombocitov občutljivi pokazatelji toksičnosti.
English: Warnings and precations
Slovenian: Opozorila in previdnostni ukrepi
English: Depending on the prescribed dose, you may have to take more than one capsule together, eventually with different strengths (content of active substance, in mg).
Slovenian: Odvisno od predpisanega odmerka boste morda morali vzeti več kapsul naenkrat, lahko v različnih jakostih (vsebnost zdravilne učinkovine v miligramih).
English: If you vomit after taking your dose, do not take a second dose on the same day.
Slovenian: Če bruhate po zaužitju odmerka, ne vzemite drugi odmerek istega dne;
English: As it cannot be excluded that the change in Cmax is clinically significant, Temozolomide Teva should be administered without food.
Slovenian: Ker ni mogoče izključiti, da je sprememba vrednosti Cmax klinično pomembna, je treba zdravilo
English: In preclinical studies in rats and rabbits receiving 150 mg/m² TMZ, teratogenicity and/or foetal toxicity were demonstrated (see section 5.3).
Slovenian: V predkliničnih študijah na podganah in kuncih, ki so dobivali TMZ v odmerkih 150 mg/m², so ugotovili teratogenost in/ali fetalno toksičnost (glejte poglavje 5.3).
English: Plasma clearance, volume of distribution and half-life are independent of dose.
Slovenian: Plazemski očistek, volumen porazdelitve in razpolovni čas niso odvisni od odmerka.
English: Swallow the capsule(s) whole with a glass of water.
Slovenian: Pogoltnite cele kapsule in popijte kozarec vode.
English: Before each new treatment cycle, your blood will be tested to see if the Temozolomide Teva dose needs to be adjusted.
Slovenian: Pred vsakim novim ciklom zdravljenja bo zdravnik preveril vašo krvno sliko, da bi ugotovil, ali je treba odmerek zdravila Temozolomide Teva prilagoditi.
English: Temozolomide Teva is used in these tumours if they return or get worse after standard treatment.
Slovenian: Zdravilo Temozolomide Teva se uporablja za zdravljenje teh tumorjev, če se po standardnem zdravljenju ponovijo ali poslabšajo.
English: TMZ monotherapy n=224
Slovenian: Samostojno zdravljenje s TMZ n = 224
English: The hard capsules are dispensed in amber glass bottles containing 5 or 20 capsules.
Slovenian: Trde kapsule so na voljo v rjavih stekleničkah, ki vsebujejo po 5 ali 20 kapsul.
English: You may be given other medicines (anti-emetics) to take before and/or after taking Temozolomide Teva to prevent or control nausea and vomiting.
Slovenian: Morda boste dobili druga zdravila (antiemetike), ki jih boste vzeli pred zdravilom Temozolomide Teva oziroma po njem, za preprečevanje ali nadzor slabosti in bruhanja.
English: drug reaction with eosinophilia and systemic symptons (DRESS)
Slovenian: Neznani reakcija na zdravilo z eozinofilijo in sistemskimi simptomi (DRESS)
English: In the tables undesirable effects are classified according to System Organ Class and frequency.
Slovenian: Neželeni učinki so v razpredelnicah razvrščeni po organskih sistemih in pogostosti.
English: Based on a population pharmacokinetic analysis in patients 19-78 years of age, clearance of TMZ is not affected by age.
Slovenian: Na podlagi populacijske farmakokinetične analize pri bolnikih, starih med 19 in 78 let, starost ne vpliva na očistek TMZ.
English: Common (≥ 1/100 to < 1/10); Uncommon (≥ 1/1,000 to < 1/100) ); Rare (≥1/10,000 to <1/1,000);
Slovenian: občasni (≥ 1/1.000 do < 1/100), redki (≥1/10.000 do <1/1.000), zelo redki (<1/10.000).
English: The colour and marking of the capsule is different for each strength (see table below).
Slovenian: Kapsule različnih jakosti se razlikujejo v barvi in oznakah (glejte spodnjo tabelo).
English: CSF penetration was confirmed in one patient; CSF exposure based on AUC of TMZ was approximately 30% of that in plasma, which is consistent with animal data.
Slovenian: Prodiranje v cerebrospinalno tekočino so potrdili pri enem bolniku; izpostavljenost cerebrospinalne tekočine na podlagi vrednosti AUC TMZ je bila približno 30 % izpostavljenosti plazme, kar ustreza podatkom, pridobljenim pri živalih.
English: Your doctor will monitor your blood regularly for any changes, and will decide if any specific treatment is needed.
Slovenian: Zdravnik bo redno preverjal vašo krvno sliko, da bi odkril morebitne spremembe, in se bo odločil, ali potrebujete zdravljenje.
English: Elderly patients appear to be at increased risk of neutropenia and thrombocytopenia, compared with younger patients.
Slovenian: Kaže, da so starejši bolniki v večji nevarnosti za nevtropenijo in trombocitopenijo v primerjavi z mlajšimi.
English: Results of the Ames/salmonella and Human Peripheral Blood Lymphocyte (HPBL) chromosome aberration tests showed a positive mutagenicity response.
Slovenian: Rezultati Amesovega testa z bakterijami salmonella in testa kromosomskih aberacij s človeškimi perifernimi krvnimi limfociti (HPBL) so pokazali pozitiven mutageni odziv.
English: - as you should be observed closely for the development of a serious form of chest infection called Pneumocystis jirovecii pneumonia (PCP).
Slovenian: - ker vas mora zdravnik natančno opazovati, ali imate znake hude oblike okužbe pljuč, ki se imenuje pljučnica Pneumocystis jirovecii (PCP).
English: The 6-month event-free survival for the ITT population was 44% with a median event-free survival of 4.6 months, which was similar to the results for the progression-free survival.
Slovenian: Šestmesečno preživetje brez dogodkov je bilo za populacijo z namenom zdravljenja 44-odstotno, s srednjim preživetjem brez dogodkov 4,6 meseca, kar je podobno rezultatom za preživetje brez napredovanja bolezni.
English: Use of TMZ in combination with other myelosuppressive agents may increase the likelihood of myelosuppression.
Slovenian: Uporaba TMZ v kombinaciji z drugimi mielosupresivnimi učinkovinami lahko poveča verjetnost za mielosupresijo.
English: Anti-emetic therapy may be administered (see section 4.4).
Slovenian: Lahko se uporabi antiemetično zdravljenje (glejte poglavje 4.4).
English: If you vomit frequently before or during treatment, ask your doctor about the best time to take Temozolomide Teva until the vomiting is under control.
Slovenian: Če pred zdravljenjem ali med njim pogosto bruhate, vprašajte zdravnika, kdaj je najbolje jemati zdravilo Temozolomide Teva, dokler se bruhanje ne umiri.
English: Allergic reactions, including anaphylaxis, angioedema
Slovenian: alergijske reakcije, vključno z anafilaksijo in angioedemom
English: If lymphopenia occurs, they are to continue the prophylaxis until recovery of lymphopenia to grade ≤ 1.
Slovenian: Če nastopi limfopenija, bolniki nadaljujejo profilakso, dokler se limfopenija ne popravi na stopnjo ≤ 1.
English: 28 August 2014
Slovenian: 28. januar 2010 Datum zadnjega podaljšanja: 28. avgust 2014
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Slovenian: Podrobne informacije o tem zdravilu so objavljene na spletnistrani Evropske agencije za zdravila http://www.ema.europa.eu.
English: In a multicentre, prospective phase II trial evaluating the safety and efficacy of oral TMZ in the treatment of patients with anaplastic astrocytoma at first relapse, the 6 month PFS was 46%.
Slovenian: V večcentričnem prospektivnem preskušanju faze II, v katerem so ocenili varnost in učinkovitost peroralnih odmerkov TMZ v zdravljenju bolnikov s prvim relapsom anaplastičnega astrocitoma, je bilo preživetje brez napredovanja bolezni po šestih mesecih 46-odstotno.
English: Very rare cases of severe rash with skin swelling, including on the palms of the hands and soles of the feet, or painful reddening of the skin and/or blisters on the body or in the mouth have been observed.
Slovenian: Opazili so zelo redke primere hudih izpuščajev z otekanjem kože, vključno z dlanmi in podplati, ali boleče in pordele kože in/ali mehurčkov na telesu ali v ustih.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, odsotnostjo encima laktaze ali malabsorpcijo glukoze/ galaktoze ne smejo jemati tega zdravila.
English: Cytotoxic lesions that develop subsequently are thought to involve aberrant repair of the methyl adduct.
Slovenian: Citotoksične lezije, ki se posledično razvijejo, so verjetno povezane z aberantnim popravilom metilnega adukta.
English: However, elderly patients (> 70 years of age) appear to be at increased risk of neutropenia and thrombocytopenia (see section 4.4).
Slovenian: Vendar kaže, da je pri starejših bolnikih (starejših od 70 let) večje tveganje za nevtropenijo in trombocitopenijo (glejte poglavje 4.4).
English: Hypersensitivity to dacarbazine (DTIC).
Slovenian: Preobčutljivost za dakarbazin.
English: In a separate phase I study, administration of TMZ with ranitidine did not result in alterations in the extent of absorption of temozolomide or the exposure to its active metabolite monomethyl triazenoimidazole carboxamide (MTIC).
Slovenian: V ločeni študiji faze I uporaba TMZ z ranitidinom ni spremenila obsega absorpcije TMZ ali izpostavljenosti njegovemu aktivnemu metabolitu monometil triazenoimidazol karboksamidu (MTIC).
English: Do not store above 30°C.
Slovenian: Shranjujte pri temperature do 30 °C.
English: Once escalated, the dose remains at 200 mg/m² per day for the first 5 days of each subsequent cycle except if toxicity occurs.
Slovenian: Ko se odmerek poveča, ostane 200 mg/m² dnevno prvih pet dni vsakega naslednjega cikla, razen v primeru toksičnosti.
English: In both trials, the primary endpoint was progression-free survival (PFS) defined by MRI scans or neurological worsening.
Slovenian: V obeh preskušanjih je bila primarna točka ocene učinkovitosti preživetje brez napredovanja bolezni (PBN), opredeljeno z magnetnoresonančnim slikanjem ali nevrološkim poslabšanjem.
English: This adds up to a 28-day treatment cycle.
Slovenian: Skupaj je to 28-dnevni cikel zdravljenja.
English: MTIC is spontaneously hydrolyzed to 5-amino-imidazole-4carboxamide (AIC), a known intermediate in purine and nucleic acid biosynthesis, and to methylhydrazine, which is believed to be the active alkylating species.
Slovenian: MTIC se spontano hidrolizira v 5-amino-imidazol-4-karboksamid (AIC), znanega posrednika pri biosintezi purina in nukleinske kisline, in v metilhidrazin, ki je verjetno aktivna alkilirajoča različica.
English: Temozolomide Teva should only be prescribed by physicians experienced in the oncological treatment of brain tumours.
Slovenian: Zdravilo Temozolomide Teva smejo predpisovati samo zdravniki, izkušeni v onkološkem zdravljenju možganskih tumorjev.
English: It is not known whether TMZ is excreted in human milk; thus, breast-feeding should be discontinued while receiving treatment with TMZ.
Slovenian: Ni znano, ali se TMZ pri ljudeh izloča v materino mleko, zato je treba v obdobju zdravljenja s TMZ
English: The lowest recommended dose is 100 mg/m².
Slovenian: Najmanjši priporočeni odmerek je 100 mg/m².
English: Data on time to worsening of neurological status favoured TMZ over procarbazine as did data on time to worsening of performance status (decrease to a KPS of < 70 or a decrease by at least 30 points).
Slovenian: Podatki o času do poslabšanja nevrološkega stanja kažejo prednost TMZ pred prokarbazinom, kar velja tudi za podatke o času do poslabšanja telesne zmogljivosti (zmanjšanje na indeks telesne zmogljivosti Karnofsky < 70 ali zmanjšanje za vsaj 30 točk).
English: In vivo, the t1/2 of MTIC was similar to that of TMZ, 1.8 hr.
Slovenian: In vivo je bila vrednost t1/2 za MTIC podobna kot za TMZ, tj. 1,8 ure.
English: However, all patients receiving TMZ, particularly patients receiving steroids, should be observed closely for the development of PCP, regardless of the regimen.
Slovenian: Vendar je pri vseh bolnikih, ki jemljejo TMZ, zlasti tistih, ki se zdravijo tudi s steroidi, treba pozorno opazovati morebitne znake PCP, ne glede na režim odmerjanja.
English: Pancytopenia, anaemia (grade 3-4), leukopenia
Slovenian: pancitopenija, anemija (stopnja 3 do 4), levkopenija
English: Side effects from clinical studies:
Slovenian: Neželeni učinki iz kliničnih študij
English: In some cases, it may be necessary to stop treatment with Temozolomide Teva.
Slovenian: V nekaterih primerih je potrebno zdravljenje z zdravilom Temozolomide Teva prekiniti.
English: Analysis of population-based pharmacokinetics of TMZ revealed that plasma TMZ clearance was independent of age, renal function or tobacco use.
Slovenian: Posebne skupine bolnikov Analiza populacijske farmakokinetike TMZ je razkrila, da je plazemski očistek TMZ neodvisen od starosti, delovanja ledvic ali uporabe tobačnih izdelkov.
English: There may be up to 6 treatment periods (cycles).
Slovenian: Zdravljenje bo obsegalo največ šest obdobij (»ciklov«).
English: Effective contraceptive precautions must be taken by both male and female patients who are taking Temozolomide Teva (see also “Male fertility” below).
Slovenian: Bolnice in bolniki, ki jemljejo zdravilo Temozolomide Teva, morajo uporabljati učinkovito kontracepcijo (glejte tudi spodaj »Plodnost pri moških«).
English: What you need to know before you take Temozolomide Teva Do not take Temozolomide Teva
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Temozolomide Teva Ne uporabljajte zdravila Temozolomide Teva
English: TMZ is an embryotoxic, teratogenic and genotoxic alkylating agent.
Slovenian: TMZ je embriotoksična, teratogena in genotoksična alkilirajoča učinkovina.
English: There is limited information in patients over 3 years of age who have taken Temozolomide Teva.
Slovenian: Število podatkov pri bolnikih, starejših od 3 let, ki so jemali zdravilo Temozolomide Teva, je omejeno.
English: An overdose of 10,000 mg (total dose in a single cycle, over 5 days) was taken by one patient and the adverse reactions reported were pancytopenia, pyrexia, multiorgan failure and death.
Slovenian: Po prevelikem odmerku 10.000 mg (skupni odmerek v posameznem ciklu, v petih dneh), ki ga je vzel en bolnik, so poročali o pancitopeniji, pireksiji, odpovedi več organov in smrti.
English: No studies have been conducted to determine the effect of TMZ on the metabolism or elimination of other medicinal products.
Slovenian: Študij, s katerimi bi ugotovili učinek TMZ na presnovo ali izločanje drugih zdravil, niso opravili.
English: Patients who received concomitant TMZ and RT in a pilot trial for the prolonged 42-day schedule were shown to be at particular risk for developing Pneumocystis jirovecii pneumonia (PCP).
Slovenian: Izkazalo se je, da je pri bolnikih, ki so se v pilotskem preskušanju sočasno zdravili s TMZ in obsevanjem v podaljšanem obdobju 42 dni, še posebej prisotno tveganje za razvoj pljučnice s povzročiteljem Pneumocystis jirovecii (PCP).
English: Grade 3 or 4 thrombocytopenia and neutropenia occurred in 19% and 17% respectively, of patients treated for malignant glioma.
Slovenian: Trombocitopenija stopnje 3 ali 4 se je pojavila pri 19 %, nevtropenija stopnje 3 ali 4 pa pri 17 % bolnikov, ki so se zdravili zaradi malignega glioma.
English: Rare (may affect up to 1 in 1,000 people): cough, infections including pneumonia.
Slovenian: Redki (pojavijo se lahko pri največ 1 od 1.000 bolnikov): kašelj, okužbe vključno s pljučnico.
English: The first dose will be 150 mg/m².
Slovenian: Prvi odmerek bo 150 mg/m².
English: - if certain kinds of blood cells are severely reduced (myelosuppression), such as your white blood cell count and platelet count.
Slovenian: - če imate hudo zmanjšano število nekaterih vrst krvnih celic (mielosupresija), na primer belih krvnih celic in krvnih ploščic.
English: Based on the pharmacokinetic properties of TMZ, it is unlikely that dose reductions are required in patients with severe hepatic impairment or any degree of renal impairment.
Slovenian: Glede na farmakokinetične lastnosti TMZ ni verjetno, da bi bilo za bolnike s hudo okvaro jeter ali katero koli stopnjo okvare ledvic treba zmanjšati odmerek.
English: Laboratory results
Slovenian: Rezultati laboratorijskih preiskav
English: Men being treated with TMZ should be advised not to father a child up to 6 months after receiving the last dose and to seek advice on cryoconservation of sperm prior to treatment (see section 4.6).
Slovenian: Moškim, ki se zdravijo s TMZ, je treba svetovati, naj še do šest mesecev po zadnjem odmerku ne zaplodijo otroka ter da se pred zdravljenjem pozanimajo o možnostih kriokonzervacije sperme (glejte poglavje 4.6).
English: Doses of 500, 750, 1,000, and 1,250 mg/m² (total dose per cycle over 5 days) have been evaluated clinically in patients.
Slovenian: Pri bolnikih so klinično ovrednotili odmerke 500, 750, 1000 in 1250 mg/m² (skupni odmerek na cikel zdravljenja v petih dneh).
English: Summary of events reported with temozolomide in the post-marketing setting* Infections and infestations*
Slovenian: Povzetek dogodkov, o katerih so poročali pri uporabi temozolomida v obdobju trženja *
English: Temozolomide Teva may make you feel tired or sleepy.
Slovenian: Jemanje zdravila Temozolomide Teva lahko povzroči utrujenost in zaspanost.
English: In a separate pharmacokinetic study, plasma pharmacokinetic profiles in patients with mild to moderate hepatic impairment were similar to those observed in patients with normal hepatic function.
Slovenian: V ločeni študiji farmakokinetike so bili plazemski farmakokinetični profili pri bolnikih z blago do zmerno okvaro jeter podobni tistim, ki so jih opazili pri bolnikih z normalnim delovanjem jeter.
English: If Temozolomide Teva comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Slovenian: Če pride zdravilo Temozolomide Teva v stik s kožo ali sluznico, prizadeti predel takoj temeljito sperite z vodo in milom.
English: Table 5 includes adverse reactions reported during clinical trials for recurrent or progressive malignant glioma and following the marketing of TMZ.
Slovenian: V razpredelnico 5 so vključeni neželeni učinki, o katerih so poročali med kliničnimi preskušanji zdravljenja ponavljajočega se ali napredujočega malignega glioma in po začetku trženja TMZ.
English: In the noncomparative trial, the PFS at 6 months was 19%, the median progression-free survival was 2.1 months, and the median overall survival 5.4 months.
Slovenian: V neprimerjalnem preskušanju je bilo preživetje brez napredovanja bolezni po šestih mesecih 19-odstotno, srednje preživetje brez napredovanja bolezni je bilo 2,1 meseca in srednje skupno preživetje 5,4 meseca.
English: No evidence of cumulative myelosuppression was observed.
Slovenian: Znakov kumulativne mielosupresije niso opazili.
English: In patients treated with TMZ, whether used in combination with RT or as monotherapy following RT for newly-diagnosed glioblastoma multiforme, or as monotherapy in patients with recurrent or progressive glioma, the reported very common adverse reactions were similar: nausea, vomiting, constipation, anorexia, headache and fatigue.
Slovenian: Pri bolnikih, ki so se zdravili s TMZ, ne glede na to, ali je bilo zdravljenje kombinirano z obsevanjem ali samostojno po obsevanju na novo diagnosticiranega multiformnega glioblastoma ali pa samostojno zdravljenje bolnikov s ponavljajočim se ali napredujočim gliomom, so bili neželeni učinki, o katerih so najpogosteje poročali, podobni - navzeja, bruhanje, zaprtost, anoreksija, glavobol in utrujenost.
English: In a study of 288 subjects with newly-diagnosed glioblastoma multiforme, Grade 4 neutropenia occurred in 3% of female vs 0% of male subjects and Grade 4 thrombocytopenia in 1% of female vs 0% of male subjects in the first cycle of therapy.
Slovenian: V študiji z 288 posamezniki z na novo diagnosticiranim multiformnim glioblastomom se je v prvem ciklu zdravljenja nevtropenija stopnje 4 pojavila pri 3 % žensk in 0 % moških, trombocitopenija stopnje 4 pa pri 1 % žensk in 0 % moških.
English: TMZ was administered as salvage therapy in the follow-up phase in 161 patients of the 282 (57%) in the RT alone arm, and 62 patients of the 277 (22%) in the TMZ + RT arm.
Slovenian: TMZ so v obdobju sledenja uporabili kot rešilno zdravljenje pri 161 bolnikih od 282 (57 %) v kraku s samim obsevanjem ter 62 bolnikih od 277 (22 %) v kraku s TMZ in obsevanjem.
English: Temozolomide Teva is used for the treatment of specific forms of brain tumours: - in adults with newly-diagnosed glioblastoma multiforme.
Slovenian: Zdravilo Temozolomide Teva se uporablja za zdravljenje določenih vrst možganskih tumorjev: - pri odraslih z novo diagnosticiranim multiformnim glioblastomom.
English: Frequency groupings are defined according to the following convention: Very common (≥ 1/10);
Slovenian: Kategorije pogostosti ustrezajo naslednjemu dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10),
English: Four weeks after completing the TMZ + RT concomitant phase, TMZ is administered for up to 6 cycles of monotherapy treatment.
Slovenian: Štiri tedne po končanem obdobju sočasnega zdravljenja s TMZ in obsevanjem se TMZ uporabi v do šestih ciklih samostojnega zdravljenja.
English: TMZ administration should be temporarily interrupted or permanently discontinued during the concomitant phase according to the haematological and non-haematological toxicity criteria as noted in Table 1.
Slovenian: V obdobju sočasnega zdravljenja je treba uporabo TMZ začasno prekiniti ali trajno opustiti, če so izpolnjena merila hematološke in nehematološke toksičnosti, navedena v razpredelnici 1.
English: Neutropenia or lymphopenia (grade 3-4), thrombocytopenia (grade 3-4)
Slovenian: nevtropenija ali limfopenija (stopnja 3 do 4), trombocitopenija (stopnja 3 do 4)
English: Amber glass bottle with white polypropylene child-resistant screw cap equipped with an induction seal of polyethylene containing 5 or 20 capsules.
Slovenian: Rjava steklenička z belim polipropilenskim pokrovčkom na navoj z zaščito za otroke, opremljena s polietilenskim indukcijskim tesnilom, ki vsebuje 5 ali 20 kapsul.
English: Tell your doctor if you notice any of these symptoms.
Slovenian: Če imate katerega od teh simptomov,
English: Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2).
Slovenian: Predpisovanje in izdaja zdravila je le s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2)
English: The hazard ratio (HR) for overall survival was 1.59 (95% CI for HR=1.33 -1.91) with a log-rank p < 0.0001 in favour of the TMZ arm.
Slovenian: Razmerje tveganja (RT) za skupno preživetje je bilo 1,59 (95-odstotni interval zaupanja za RT = 1,33 - 1,91) z vrednostjo p testa log-rank < 0,0001 v korist kraka s TMZ.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Slovenian: V vsaki kategoriji pogostosti so neželeni učinki razvrščeni po izrazitosti, in sicer v padajočem vrstnem redu.
English: Once the radiotherapy is completed, you will interrupt treatment for 4 weeks.
Slovenian: Po končanem obsevanju boste prekinili zdravljenje za štiri tedne, da si bo vaše telo lahko opomoglo.
English: What Temozolomide teva is and what it is used for
Slovenian: Kaj je zdravilo Temozolomide Teva in za kaj ga uporabljamo
English: Other medicines and Temozolomide Teva
Slovenian: Druga zdravila in zdravilo Temozolomide Teva
English: Micturition frequency, urinary incontinence
Slovenian: pogosto uriniranje, urinska inkontinenca urinska inkontinenca