FrancophonIA/ELRC3.0 huggingface dataset:
English: Specifically, for C. glabrata, the MICs of voriconazole for fluconazole-resistant isolates are proportionally higher than are those of fluconazole-susceptible isolates.
Danish: Dette ses især hos fluconazol-resistente isolater af C. glabrata, hvor MIC-værdierne for voriconazol er forholdsmæssigt højere end hos fluconazol-følsomme isolater.
English: Co-administration with ergot alkaloids (ergotamine, dihydroergotamine), which are CYP3A4 substrates, since increased plasma concentrations of these medicinal products can lead to ergotism (see section 4.5).
Danish: Samtidig administration af sekalealkaloider (ergotamin, dihydroergotamin), som er CYP3A4substrater, da øgede plasmakoncentrationer af disse lægemidler kan medføre ergotisme (se pkt.
English: Macrolide antibiotics Erythromycin (1 g BID) [CYP3A4 inhibitor] Azithromycin (500 mg QD)
Danish: Macrolidantibiotika Erythromycin (1 g BID) [CYP3A4-hæmmer] Azithromycin (500 mg QD)
English: Each vial of Voriconazole Hikma contains 217.6 mg of sodium per vial.
Danish: Hvert hætteglas med Voriconazole Hikma indeholder 217,6 mg natrium.
English: Immune system disorders hypersensitivity anaphylactoid reaction
Danish: Immunsystemet overfølsomhedsreaktioner anafylaktoid reaktion
English: Maintenance Dose (after first 24 hours)
Danish: Vedligeholdelsesdosis (efter de første 24 timer)
English: Interaction table
Danish: Interaktionsskema
English: • Phenobarbital (used for severe insomnia and seizures)
Danish: • Phenobarbital (medicin mod alvorlig søvnløshed og krampeanfald)
English: • Quinidine (used for irregular heart beat)
Danish: • Quinidin (medicin mod uregelmæssig puls)
English: Ritonavir (potent CYP450 inducer; CYP3A4 inhibitor and substrate) Co-administration of voriconazole and low dose ritonavir (100 mg twice daily) should be avoided unless an assessment of the benefit/risk to the patient justifies the use of voriconazole (see sections 4.5 and 4.3).
Danish: Ritonavir (potent CYP450-induktor; CYP3A4-hæmmer og -substrat) Samtidig administration af voriconazol og lavdosis ritonavir (100 mg 2 gange dagligt) bør undgås, medmindre en vurdering af benefit/risk forholdet for patienten retfærdiggør brugen af voriconazol (se pkt.
English: Voriconazole Hikma contains the active substance voriconazole.
Danish: Voriconazole Hikma indeholder det aktive stof voriconazol.
English: Other treated fungal infections (often with partial or complete response) included isolated cases of Alternaria spp., Blastomyces dermatitidis, Blastoschizomyces capitatus, Cladosporium spp., Coccidioides immitis, Conidiobolus coronatus, Cryptococcus neoformans, Exserohilum rostratum, Exophiala spinifera, Fonsecaea pedrosoi, Madurella mycetomatis, Paecilomyces lilacinus, Penicillium spp.
Danish: Andre behandlede svampeinfektioner (ofte med delvist eller fuldstændigt respons) omfatter isolerede tilfælde af Alternaria spp., Blastomyces dermatitidis, Blastoschizomyces capitatus, Cladosporium spp., Coccidioides immitis, Conidiobolus coronatus, Cryptococcus neoformans, Exserohilum rostratum, Exophiala spinifera, Fonsecaea pedrosoi, Madurella mycetomatis, Paecilomyces lilacinus, Penicillium spp., herunder P. marneffei, Phialophora richardsiae, Scopulariopsis brevicaulis og Trichosporon spp., herunder T. beigelii-infektioner.
English: Patients have developed severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) (uncommon), toxic epidermal necrolysis (TEN) (rare), drug reaction with eosinophilia and systemic symptoms (DRESS) (rare) and erythema multiforme (rare) during treatment with voriconazole (see section 4.4).
Danish: Patienterne har udviklet svære kutane bivirkninger (SCAR), herunder Stevens-Johnsons syndrom (SJS) (ikke almindelig), toksisk epidermal nekrolyse (TEN) (sjælden), lægemiddelreaktion med eosinofili og systemiske symptomer (DRESS) (sjælden) og erythema multiforme (sjælden) under behandling med voriconazol (se pkt.
English: • Sulfonylureas (e.g., tolbutamide, glipizide and glyburide) (used for diabetes)
Danish: • Sulfonylurinstoffer (f.eks. tolbutamid, glipizid og glyburid) (medicin mod diabetes)
English: Hospira UK Limited Queensway, Royal Leamington Spa Warwickshire
Danish: Queensway, Royal Leamington Spa
English: Co-administration with CYP3A4 substrates, terfenadine, astemizole, cisapride, pimozide or quinidine since increased plasma concentrations of these medicinal products can lead to QTc prolongation and rare occurrences of torsades de pointes (see section 4.5).
Danish: Samtidig administration af CYP3A4-substraterne terfenadin, astemizol, cisaprid, pimozid eller quinidin, da øgede plasmakoncentrationer af disse lægemidler kan medføre forlænget QTc og i sjældne tilfælde torsades de pointes (se pkt.
English: There have been post-marketing reports of prolonged visual adverse events (see section 4.4).
Danish: Der er efter markedsføring rapporteret om langvarige synsrelaterede bivirkninger (se pkt.
English: The majority of rashes were of mild to moderate severity.
Danish: Sværhedsgraden af størstedelen af udslættene var mild til moderat.
English: Co-administration with rifampicin, carbamazepine and phenobarbital since these medicinal products are likely to decrease plasma voriconazole concentrations significantly (see section 4.5).
Danish: Samtidig administration af rifampicin, carbamazepin og phenobarbital, da disse lægemidler sandsynligvis reducerer plasmakoncentrationerne af voriconazol signifikant (se pkt.
English: • invasive aspergillosis (a type of fungal infection due to Aspergillus sp.),
Danish: • invasiv aspergillose (en infektion forårsaget af Aspergillus-arter)
English: It is likely that these subjects may metabolize voriconazole more similarly to children than to adolescents/adults.
Danish: Det er sandsynligt, at disse patienters metabolisering af voriconazol mere ligner børns end voksnes.
English: Voriconazole exposures in the majority of adolescent patients were comparable to those in adults receiving the same dosing regimens.
Danish: Hos størstedelen af de unge patienter var voriconazoleksponering sammenlignelig med den for voksne i samme dosisregimen.
English: including A. flavus, A. fumigatus, A. terreus, A. niger, A. nidulans, Candida spp., including C. albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis and limited numbers of C. dubliniensis, C. inconspicua and C. guilliermondii, Scedosporium spp., including S. apiospermum, S. prolificans and Fusarium spp.
Danish: Klinisk virkning, defineret som delvist eller fuldstændigt respons, er vist over for Aspergillus spp., herunder A. flavus, A. fumigatus, A. terreus, A. niger, A. nidulans, Candida spp., herunder C. albicans, C. glabrata, C. krusei, C. parapsilosis og C. tropicalis samt et begrænset antal af C. dubliniensis, C. inconspicua og C. guilliermondii, Scedosporium spp., herunder S. apiospermum, S. prolificans og Fusarium spp.
English: • Rifabutin (used for treating tuberculosis).
Danish: • Rifabutin (medicin mod tuberkulose).
English: • Seizures, tremors or uncontrolled muscle movements, tingling or abnormal skin sensations, increase in muscle tone, sleepiness, dizziness
Danish: • Krampeanfald, rysten eller ukontrollerede muskelbevægelser, prikken eller unormal hudfornemmelse, øget muskelspænding, søvnighed, svimmelhed
English: • Blood cholesterol increased, blood urea increased
Danish: • Forhøjet kolesterol i blodet, forhøjet urinstof i blodet
English: Warfarin (30 mg single dose, coadministered with 300 mg BID voriconazole) [CYP2C9 substrate] Other oral coumarins (e.g., phenprocoumon, acenocoumarol) [CYP2C9 and CYP3A4 substrates]
Danish: Antikoagulantia Warfarin (30 mg enkeltdosis, administeret sammen med 300 mg BID voriconazol) [CYP2C9-substrat] Andre orale coumariner (f.eks. phenprocoumon, acenocoumarol) [CYP2C9- og CYP3A4substrater]
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Danish: V. Ved at indrapportere bivirkninger kan De hjælpe med at fremskaffe mere information om sikkerheden af dette lægemiddel.
English: hepatic failure, hepatomegaly, cholecystitis, cholelithiasis
Danish: leversvigt, hepatomegali, kolecystitis, cholelithiasis
English: Rifabutin Cmax ↑ 195% Rifabutin AUCτ ↑ 331% Compared to voriconazole 200 mg BID,
Danish: Rifabutin Cmax ↑ 195 % Rifabutin AUCτ ↑ 331 % Sammenlignet med voriconazol 200 mg BID
English: Patients being treated with voriconazole are likely to be treated concomitantly with nephrotoxic medicinal products and have concurrent conditions that may result in decreased renal function (see section 4.8).
Danish: Patienter, der behandles med voriconazol, vil ofte samtidig være i behandling med nefrotoksisk medicin og have samtidige tilstande, der kan medføre nedsat nyrefunktion (se pkt.
English: Vascular disorders hypotension, phlebitis thrombophlebitis, lymphangitis
Danish: Vaskulære sygdomme hypotension, flebitis tromboflebitis, lymfangitis
English: Sulfonylureas (e.g., tolbutamide, glipizide, glyburide) [CYP2C9 substrates]
Danish: Sulfonylurinstoffer(f.eks. tolbutamid, glipizid, glyburid) [CYP2C9-substrater]
English: Required Volumes of 10 mg/ml Voriconazole Hikma Concentrate
Danish: Nødvendige mængder af koncentrat med 10 mg/ml Voriconazole Hikma
English: Investigations blood creatinine increased blood urea increased, blood cholesterol increased
Danish: Undersøgelser forhøjet serumkreatinin forhøjet serumcarbamid, forhøjet kolesterol i blodet
English: Acute renal failure has been observed in severely ill patients undergoing treatment with voriconazole.
Danish: Der er observeret akut nyresvigt hos svært syge patienter i behandling med voriconazol.
English: • Abnormal brain function, Parkinson-like symptoms, nerve injury resulting in numbness, pain,
Danish: • Unormal hjernefunktion, Parkinson-lignende symptomer, nerveskade, som giver følelsesløshed, smerter, prikkende eller brændende fornemmelse i hænder eller fødder
English: The efficacy of voriconazole compared to the regimen of amphotericin B followed by fluconazole in the primary treatment of candidaemia was demonstrated in an open, comparative study.
Danish: Behandling af candidæmi hos non-neutropene patienter Effekten af voriconazol sammenlignet med behandling med amphotericin B efterfulgt af fluconazol i primær behandling af candidæmi blev vist i et åbent komparativt studie.
English: Tell your doctor if you are taking the following medicine, as treatment with Voriconazole Hikma at the same time should be avoided if possible:
Danish: Fortæl det til lægen, hvis De tager følgende medicin, da behandling samtidig med Voriconazole Hikma bør undgås, hvis det er muligt:
English: • Pimozide (used for treating mental illness)
Danish: • Pimozid (medicin mod psykiske sygdomme)
English: [CYP3A4 substrate; CYP2C19 inhibitor]
Danish: [CYP3A4-substrat; CYP2C19hæmmer]
English: When initiating voriconazole in patients already on ciclosporin it is recommended that the ciclosporin dose be halved and ciclosporin level carefully monitored.
Danish: Når voriconazol-behandling startes hos patienter, der allerede får ciclosporin, anbefales det, at ciclosporindosis halveres, og at ciclosporinkoncentrationerne monitoreres nøje.
English: Skin rashes which may lead to severe blistering and peeling of the skin characterized by a flat, red area on the skin that is covered with small confluent bumps, redness of the skin
Danish: • Hududslæt, der kan medføre udbredt blæredannelse og afskalning af huden, og som er kendetegnet ved et fladt, rødt område på huden, der er dækket af små sammenflydende ujævnheder, hudrødme
English: Co-administration of voriconazole and low dose ritonavir (100 mg BID) should be avoided, unless an assessment of the benefit/risk to the patient justifies the use of voriconazole.
Danish: Samtidig administration af voriconazol og lav-dosis ritonavir (100 mg BID) bør undgås, medmindre en evaluering af fordele og ulemper for patienten vil retfærdiggøre anvendelse af voriconazol.
English: Compared to voriconazole 200 mg BID,
Danish: Sammenlignet med voriconazol 200 mg BID
English: Liver function test abnormalities may be associated with higher plasma concentrations and/or doses.
Danish: Leverfunktionsafvigelserne kan associeres med højere plasmakoncentrationer og/eller doser.
English: Phenytoin Cmax ↑ 67% Phenytoin AUCτ ↑ 81% Compared to voriconazole 200 mg BID,
Danish: Phenytoin Cmax ↑ 67 % Phenytoin AUCτ ↑ 81 % Sammenlignet med voriconazol 200 mg BID
English: In an oral multiple dose study Cmax and AUCτ in healthy elderly males (≥ 65 years) were 61 % and 86 % higher, respectively, than in healthy young males (18-45 years).
Danish: I et oralt flerdosisstudie med raske, ældre mænd (≥65 år) var Cmax og AUCτ henholdsvis 61 % og 86 % højere end hos raske, unge mænd (18-45 år).
English: Voriconazole was compared to itraconazole as primary prophylaxis in an open-label, comparative, multicenter study of adult and adolescent allogeneic HSCT recipients without prior proven or probable IFI.
Danish: Voriconazol blev sammenlignet med itraconazol som primær profylakse i et åbent, komparativt multicenterstudie hos voksne og unge, der havde fået allogen HSCT, uden forudgående påvist eller sandsynlig invasiv svampeinfektion.
English: Voriconazole Hikma is presented in packs of 1 or 5 glass vials as a powder for solution for infusion.
Danish: Voriconazole Hikma fås i pakninger med 1 eller 5 hætteglas som pulver til infusionsvæske, opløsning.
English: • Double vision, serious conditions of the eye including: pain and inflammation of the eyes and eyelids, , abnormal eye movement, damage to the optic nerve resulting in vision impairment, optic disc swelling
Danish: • Dobbeltsyn, alvorlige øjentilstande, herunder: smerter og betændelsestilstand i øjne og øjenlåg, unormale øjenbevægelser, beskadigelse af synsnerven, der medfører nedsat syn, hævelse af synsnervepapillen
English: It should be noted that an 8 mg/kg intravenous dose will provide voriconazole exposure approximately 2-fold higher than a 9 mg/kg oral dose.
Danish: Det bør bemærkes, at en dosis på 8 mg/kg intravenøst giver en voriconazoleksponering, der er ca. 2 gange højere end den, der ses ved 9 mg/kg oralt.
English: In patients with moderate to severe renal dysfunction (serum creatinine levels >2.5 mg /dl), accumulation of the intravenous vehicle, SBECD, occurs (see sections 4.2 and 4.4).
Danish: Hos patienter med moderat til alvorlig nyrefunktionssvigt (serum-kreatininniveauer >2,5 mg/dl) ses akkumulering af det intravenøse hjælpestof SBECD (se pkt.
English: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) [CYP2C9 substrates] Ibuprofen (400 mg single dose)
Danish: Nonsteroide antiinflammatoriske lægemidler (NSAID'er) [CYP2C9-substrater] Ibuprofen (400 mg enkeltdosis)
English: • Small dry scaly skin patches, sometimes thick with spikes or ‘horns'
Danish: • Små, tørre, skællede hudpletter, af og til fortykket med hård eller forhornet hud
English: [CYP3A4 substrates, inhibitors or CYP450 inducers]
Danish: [CYP3A4-substrater, -hæmmere eller CYP450-induktorer]
English: Voriconazole Hikma has a moderate influence on the ability to drive and use machines.
Danish: Voriconazole Hikma kan påvirke evnen til at føre motorkøretøj eller betjene maskiner i moderat grad.
English: In vitro, voriconazole displays broad-spectrum antifungal activity with antifungal potency against Candida species (including fluconazole resistant C. krusei and resistant strains of C. glabrata and C. albicans) and fungicidal activity against all Aspergillus species tested.
Danish: Voriconazol udviser bredspektret antimykotisk aktivitet in vitro med antimykotisk styrke over for Candida- arter (herunder fluconazol-resistente C. krusei og resistente stammer af C. glabrata og C.
English: acute respiratory distress syndrome, pulmonary oedema
Danish: akut respiratory distress-syndrom, lungeødem
English: Rifabutin (Potent CYP450 inducer)
Danish: Rifabutin (potent CYP450-induktor)
English: Caution should be used in prescribing Voriconazole Hikma to patients with hypersensitivity to other azoles (see also section 4.8).
Danish: Forsigtighed tilrådes, når Voriconazole Hikma gives til patienter, der er overfølsomme over for andre azoler (se også pkt.
English: PHARMACEUTICAL FORM Powder for solution for infusion (powder for infusion) White to off-white lyophilised cake.
Danish: Pulver til infusionsvæske, opløsning (pulver til infusionsvæske) Hvid til råhvid lyofiliseret (frysetørret) kage.
English: • Statins (e.g., atorvastatin, simvastatin) (used for lowering cholesterol)
Danish: • Statiner (f.eks. atorvastatin, simvastatin) (kolesterolsænkende medicin)
English: Dose after the first 24 hours (Maintenance Dose)
Danish: Dosis efter de første 24 timer (vedligeholdelsesdosis)
English: • Fluconazole (used for treating fungal infections)
Danish: • Fluconazol (bruges mod svampeinfektioner)
English: Liver dysfunction has usually been reversible on discontinuation of therapy (see section 4.8).
Danish: Leverinsufficiens har som regel været reversibel ved seponering af behandling (se pkt.
English: General pharmacokinetic characteristics
Danish: Generelle farmakokinetiske karakteristika
English: • Loss of most fibers in the optic nerve clouding of the cornea, involuntary movement of the eye
Danish: • Tab af de fleste fibre i synsnerven, uklar hornhinde, ufrivillige øjenbevægelser
English: Voriconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems.
Danish: Det er vist, at voriconazol er mere selektiv for fungale CYP450-enzymsystemer end over for forskellige mammale CYP450-enzymsystemer.
English: Methadone (32-100 mg QD) [CYP3A4 substrate]
Danish: Methadon (32-100 mg QD) [CYP3A4-substrat]
English: • Efavirenz (used for treating HIV) in doses of 400 mg and above once daily
Danish: • Efavirenz (til behandling af hiv) i doser på 400 mg en gang daglig og derover
English: • Astemizole (used for allergy)
Danish: • Astemizol (medicin mod allergi)
English: No dose adjustment of voriconazole is recommended.
Danish: Dosisjustering af voriconazol anbefales ikke.
English: If the liver function tests become markedly elevated, Voriconazole Hikma should be discontinued, unless the medical judgment of the risk-benefit of the treatment for the patient justifies continued use.
Danish: Hvis leverfunktionsværdierne forhøjes mærkbart, bør Voriconazole Hikma seponeres, medmindre fortsat anvendelse kan forsvares på grundlag af en medicinsk vurdering af risk-benefit-forholdet for patienten.
English: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), which can be life-threatening or fatal, have been reported with the use of voriconazole.
Danish: Der er rapporteret om svære kutane bivirkninger (SCAR), såsom Stevens-Johnsons syndrom (SJS), toksisk epidermal nekrolyse (TEN), lægemiddelreaktion med eosinofili og systemiske symptomer (DRESS), som kan være livstruende eller fatale, ved brug af voriconazol.
English: Metabolism and nutrition disorders oedema peripheral hypoglycaemia, hypokalaemia, hyponatraemia
Danish: Metabolisme og ernæring perifert ødem hypoglykæmi, hypokaliæmi, hyponatriæmi
English: General disorders and administration site conditions pyrexia chest pain, face oedema11, asthenia, chills infusion site reaction, influenza like illness
Danish: Almene symptomer og reaktioner på administrationsstedet pyreksi brystsmerter, ansigtsødem11, asteni, kulderystelser reaktioner på infusionsstedet, influenzalignende sygdom
English: No pharmacokinetic data are available for patients with severe hepatic cirrhosis (Child-Pugh C) (see sections 4.2 and 4.4).
Danish: Der er ingen tilgængelige farmakokinetiske data på patienter med alvorlig levercirrose (Child-Pugh-klasse C) (se pkt.
English: Fertility In an animal study, no impairment of fertility was demonstrated in male and female rats (see section 5.3).
Danish: Fertilitet Dyrestudier viste ikke nedsat fertilitet hos han- og hunrotter (se pkt.
English: Infusion-related reactions, predominantly flushing and nausea, have been observed during administration of the intravenous formulation of voriconazole.
Danish: Infusionsrelaterede reaktioner, overvejende rødmen (”flushing”) og kvalme, er set efter indgift af intravenøs voriconazol.
English: • serious invasive Candida sp. infections when the fungus is resistant to fluconazole (another antifungal medicine),
Danish: • alvorlige invasive infektioner med Candida-arter, når svampen er resistent over for fluconazol
English: The recommended dose for children and teenagers is as follows:
Danish: Børn og teenagere Den anbefalede dosis til børn og teenagere:
English: Serious dermatological adverse reactions
Danish: Alvorlige dermatologiske bivirkninger
English: In patients with moderate to severe renal dysfunction (creatinine clearance < 50 ml/min), accumulation of the intravenous vehicle, SBECD, occurs.
Danish: Der kan hos patienter med moderat til svær nyreinsufficiens (kreatininclearance < 50 ml/min) ses akkumulering af det intravenøse hjælpestof SBECD.
English: Rifampicin (600 mg QD) [potent CYP450 inducer]
Danish: Rifampicin (600 mg QD) [potent CYP450-induktor]
English: (see section 4.5, for lower doses see section 4.4).
Danish: 4.5, for lavere doser se pkt.
English: • Ergot alkaloids (e.g., ergotamine, dihydroergotamine; used for migraine)
Danish: • Sekalealkaloider (f.eks. ergotamin, dihydroergotamin, medicin mod migræne)
English: An 8 mg/kg intravenous dose will provide voriconazole exposure approximately 2-fold higher than a 9 mg/kg oral dose.
Danish: En 8 mg/kg intravenøs dosis giver en voriconazoleksponering, der er ca. 2 gange højere end den, der ses ved en 9 mg/kg oral dosis.
English: • Vinca alkaloids (e.g., vincristine and vinblastine) (used in treating cancer)
Danish: • Vinkaalkaloider (f.eks. vincristin og vinblastin) (medicin mod cancer)
English: There have been post-marketing reports of pancreatitis in paediatric patients.
Danish: Efter markedsføring er der set tilfælde af pancreatitis hos børn.
English: Phenytoin [CYP2C9 substrate and potent CYP450 inducer] 300 mg QD
Danish: Phenytoin [CYP2C9-substrat og potent CYP450-induktor] 300 mg QD
English: Hikma Italia S.p.A. Tél/Tel: + 39 0382 1751801
Danish: Tél/Tel: + 39 0382 1751801
English: Prednisolone (60 mg single dose) [CYP3A4 substrate]
Danish: Prednisolon (60 mg enkeltdosis) [CYP3A4-substrat]
English: Voriconazole Cmax and AUCτ ↔ No dose adjustment
Danish: Voriconazol Cmax og AUCτ ↔ Ingen dosisjustering
English: • Rifampicin (used for treating tuberculosis)
Danish: • Rifampicin (medicin mod tuberkulose)
English: In an oral multiple dose study, AUCτ was similar in subjects with moderate hepatic cirrhosis (Child-Pugh B) given a maintenance dose of 100 mg twice daily and subjects with normal hepatic function given 200 mg twice daily.
Danish: I et oralt flerdosisstudie var AUCτ ens for personer med moderat levercirrose (Child-Pugh-klasse B), der fik en vedligeholdelsesdosis på 100 mg 2 gange dagligt, og personer med normal leverfunktion, der fik 200 mg to gange dagligt.
English: Co-administration of standard doses of voriconazole with efavirenz doses of 400 mg once daily or higher is contraindicated, because efavirenz significantly decreases plasma voriconazole concentrations in healthy subjects at thesedoses.
Danish: Samtidig administration af standarddoser af voriconazol sammen med efavirenz-doser på 400 mg 1 gang daglig eller derover er kontraindiceret, da efavirenz ved disse doser reducerer plasmakoncentrationen af voriconazol signifikant hos raske forsøgspersoner.
English: Other HIV Protease Inhibitors (e.g., saquinavir, amprenavir and nelfinavir)* [CYP3A4 substrates and inhibitors]
Danish: Andre hiv-proteasehæmmere (f.eks. saquinavir, amprenavir og nelfinavir)* [CYP3A4-substrater oghæmmere]
English: Itraconazole N=241
Danish: Itraconazol n=241
English: EU/1/15/1004/001 1 Pack EU/1/15/1004/002 5 Pack
Danish: EU/1/15/1004/002 pakning med 5
English: Co-administration of voriconazole and sirolimus is contraindicated (see section 4.3).
Danish: Samtidig administration af voriconazol og sirolimus er kontraindiceret (se pkt.
English: Everolimus [CYP3A4 substrate, P-gp substrate]
Danish: Everolimus [CYP3A4-substrat, P-gpsubstrat]