FrancophonIA/ELRC3.0 huggingface dataset:
English: Step 1.
Croatian: 1. korak Priprema
English: • feeling breathless or a tight chest or throat
Croatian: • osjećaj gubitka daha ili stezanja u prsištu ili grlu
English: • The Techne DB-3 Dri Block Heater is fully validated for use in the constitution of Myocet liposomal.
Croatian: • Grijač Techne DB-3 Dri Block je potpuno validiran za uporabu prilikom priprave lijeka Myocet liposomal.
English: This should be taken into consideration by patients on a controlled sodium diet.
Croatian: To trebaju uzeti u obzir bolesnice koje su na dijeti s ograničenim unosom natrija.
English: Aseptic technique must be strictly observed throughout handling of Myocet liposomal, since no preservative is present.
Croatian: Potrebno je strogo se pridržavati aseptične tehnike tijekom rukovanja lijekom Myocet liposomal s obzirom da lijek ne sadrži konzervans.
English: - If you have any further questions, ask your doctor or pharmacist or nurse.
Croatian: - Ako imate dodatnih pitanja, obratite se svom liječniku, ljekarniku ili medicinskoj sestri.
English: Myocet liposomal is likely to interact with substances that are known to interact with conventional doxorubicin.
Croatian: Vjerojatno je da će Myocet liposomal stupiti u interakciju s tvarima za koje se zna da su u interakciji sa standardnim doksorubicinom.
English: Myocet liposomal must be reconstituted prior to administration.
Croatian: Myocet liposomal se mora rekonstituirati prije primjene.
English: Myocet liposomal should be administered by intravenous infusion over a period of 1 hour.
Croatian: Myocet liposomal treba primjenjivati intravenskom infuzijom u trajanju od 1 sata.
English: Bilirubin > ULN but < 50 μmol/l
Croatian: Bilirubin > GGN ali < 50 μmol/l
English: - Do not use this medicine if you notice that it shows evidence of discoloration, precipitation or any other particulate matter.
Croatian: Ovaj lijek se ne smije upotrijebiti ako primijetite znakove promjene boje, taloženja ili sadrži čestice.
English: The peak levels of doxorubicinol occur in the plasma later with Myocet liposomal than with conventional doxorubicin.
Croatian: Vršne razine doksorubicinola javljaju se u plazmi kasnije kod lijeka Myocet liposomal nego kod standardnog doksorubicina.
English: PARTICULARS TO APPEAR ON THE INTERMEDIATE PACKAGING (used with outer carton of 2 sets of 3 constituents)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKIRANJU (koristi se s vanjskim pakiranjem od 2 kompleta s 3 sastojka)
English: If you are not sure, talk to your doctor or nurse before having Myocet liposomal.
Croatian: Ako niste sigurni, razgovarajte sa svojim liječnikom ili medicinskom sestrom prije početka uzimanja lijeka Myocet liposomal.
English: These may be signs of a liver problem called jaundice.
Croatian: To mogu biti znakovi poremećaja jetre odnosno žutice.
English: • you have ever had heart problems such as a heart attack, heart failure or you have had high blood pressure for a long time
Croatian: Razgovarajte sa svojim liječnikom ili medicinskom sestrom prije početka uzimanja ovog lijeka: • ako ste ikada imali tegoba sa srcem kao što je srčani udar, zatajenje srca ili ste dulje vrijeme imali visoki krvni tlak • ako imate tegoba s jetrom.
English: Metabolism and nutrition disorders
Croatian: Poremećaji metabolizma i prehrane anoreksija
English: Remove venting device.
Croatian: Uklonite uređaj za odzračivanje.
English: 3 Painful erythema, oedema or ulcers and cannot eat
Croatian: 3 Bolni eritem, edem ili ulceracije ali bolesnik ne može jesti.
English: • streptozotocin - for cancer of the pancreas
Croatian: • varfarin - za razrjeđivanje krvi • streptozotocin - za liječenje karcinoma pankreasa
English: Myocet liposomal must not be administered by the intramuscular or subcutaneous route or as a bolus injection.
Croatian: Myocet liposomal se ne smije primjenjivati intramuskularnim ili supkutanim putem ili u obliku bolus injekcije.
English: • difficulty breathing, chest pains
Croatian: • otežano disanje, bolovi u prsima
English: Myocet liposomal (60 mg/m2) + CPA (600 mg/m2) was compared with conventional doxorubicin + CPA (at the same doses) and Myocet liposomal (75 mg/m2) + CPA (600 mg/m2) was compared to epirubicin + CPA (at the same doses).
Croatian: Uspoređen je Myocet liposomal (60 mg/m2) + CPA (600 mg/m2) sa standardnim doksorubicinom + CPA (u istim dozama) i Myocet liposomal (75 mg/m2) + CPA (600 mg/m2) s epirubicinom + CPA (u istim dozama).
English: Tell your doctor or nurse straight away if you notice any of the following side effects.
Croatian: Odmah obavijestite svog liječnika ili medicinsku sestru ako primijetite bilo koju od sljedećih nuspojava.
English: After reconstitution the finished product must be further diluted in 0.9% (w/v) sodium chloride for injection, or 5% (w/v) glucose solution for injection to a final volume of 40 ml to 120 ml so that a final concentration of 0.4 mg/ml to 1.2 mg/ml doxorubicin is obtained.
Croatian: Nakon rekonstitucije, gotovi lijek treba dalje razrijediti u 0,9%-tnoj otopini natrijeva klorida za injekciju ili u 5%-tnoj (w/v) otopini glukoze za injekciju do konačnog volumena od 40 ml do 120 ml tako da se dobije konačna koncentracija od 0,4 mg/ml do 1,2 mg/ml doksorubicina.
English: Antitumour efficacy summary for combination and single-agent studies
Croatian: Sažetak antitumorske djelotvornosti za ispitivanja s pojedinačnim i kombiniranim lijekovima
English: Wait one week and if the symptoms improve redose at 100% dose
Croatian: Pričekajte tjedan dana te ako se simptomi poboljšaju nastavite liječenje sa 100% doze.
English: Grade
Croatian: Stupanj
English: Vial 3 - buffer
Croatian: Bočica 3 - pufer
English: In a third trial, Myocet liposomal (75 mg/m2) monotherapy was compared with conventional doxorubicin monotherapy (at the same dose).
Croatian: U trećem ispitivanju, monoterapija lijekom Myocet liposomal (75 mg/m2) bila je uspoređena sa standardnom monoterapijom doksorubicinom (pri istoj dozi).
English: The Techne DB-3 Dri Block Heater is fully validated for use in the constitution of Myocet liposomal.
Croatian: Grijač Techne DB-3 Dri Block je potpuno validiran za uporabu prilikom priprave lijeka Myocet liposomal.
English: Then IMMEDIATELY (within 2 minutes) inject Ph-adjusted liposomes into vial of heated reconstituted doxorubicin HCl.
Croatian: Potom ODMAH (unutar dvije minute) injicirajte liposome s podešenim pH u bočicu sa zagrijanim rekonstituiranim doksorubicinom HCl.
English: Myocet liposomal is available in cartons containing 1 set or 2 sets of the three constituent vials.
Croatian: Myocet liposomal je dostupan u kutijama koje sadrže 1 ili 2 kompleta bočica od tri sastojka.
English: • SHAKE VIGOROUSLY.
Croatian: • SNAŽNO PROTRESITE.
English: Nervous system disorders
Croatian: Poremećaji živčanog sustava nesanica
English: • swollen, red and blistering skin around where the drip was given
Croatian: • natečena, crvena koža s mjehurićima oko područja primjene dripa
English: It is supplied as a three-vial system: doxorubicin HCl, liposomes and buffer.
Croatian: Myocet liposomal se isporučuje kao sustav od tri bočice: doksorubicin HCl, liposomi i pufer.
English: What you need to know before you are given Myocet liposomal Do not have Myocet liposomal:
Croatian: Što morate znati prije nego počnete primati Myocet liposomal
English: The reduced risk of cardiotoxicity has also been shown in a retrospective analysis in patients who had received prior adjuvant doxorubicin (log-rank P=0.001, Hazard Ratio=5.42).
Croatian: Smanjeni rizik od kardiotoksičnosti također je pokazala retrospektivna analiza bolesnika koji su prethodno adjuvantno liječeni doksorubicinom (log-rang P =
English: Myocet liposomal doxorubicin HCl IV use
Croatian: Myocet liposomal doksorubicin HCl i.v. primjena
English: Type I flint glass tubing vials sealed with siliconised grey stopper and green flip-off aluminium seals, containing not less than 1.9 ml of liposomes.
Croatian: Bočice od silikatnog stakla zatvorene silikoniziranim sivim čepovima i zelenim aluminijskim poklopcima koje sadrže najmanje 1,9 ml liposoma.
English: phenobarbital, phenytoin and warfarin.
Croatian: Interakcije doksorubicina također su prijavljene za streptozocin, fenobarbital, fenitoin i varfarin.
English: The major circulating metabolite of doxorubicin, doxorubicinol, is formed via aldo-keto-reductase.
Croatian: doksorubicinol stvara se djelovanjem aldo-keto-reduktaze.
English: Glass vials sealed with siliconised grey stopper and blue aluminium flip-off seals, containing not less than 3 ml of buffer.
Croatian: Staklene bočice zatvorene silikoniziranim sivim čepom i plavim aluminijskim poklopcima koje sadrže najmanje 3 ml pufera.
English: Once constituted, the liposomal dispersion for infusion containing liposome-encapsulated doxorubicin should be a red orange opaque homogeneous dispersion.
Croatian: Nakon priprave, liposomska disperzija za infuziju koja sadrži doksorubicin enkapsuliran u liposomima treba biti crvenonarančasta neprozirna homogena disperzija.
English: Modification more and/or platelets 100,000 or more then redose at 25% dose reduction
Croatian: i/ili trombociti 100 000 ili više pa onda nastavite liječenje s 50%
English: However, reduction of the QRS complex is considered more indicative of cardiac toxicity.
Croatian: kompleksa smatra se značajnim pokazateljem kardiotoksičnosti.
English: Skin and subcutaneous tissue disorders
Croatian: Poremećaji kože i potkožnog tkiva alopecija
English: • sodium hydroxide
Croatian: • natrijev hidroksid
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Outer carton (1 set of 3 constituents)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Vanjsko pakiranje (1 komplet od 3 sastojka)
English: • Heat the reconstituted doxorubicin HCl vial in the Techne DB-3 Dri Block heater with the thermometer in the block reading (75°C-76°C) for 10 minutes (not to exceed 15 minutes).
Croatian: • Zagrijavajte bočicu rekonstituiranog doksorubicin HCl-a na grijaču bloku Techne DB-3 Dri Block s termometrom u bloku koji očitava (75°C-76°C) tijekom 10 minuta (ne dulje od 15 minuta).
English: Wait one week and if symptoms improve redose at 25% dose reduction
Croatian: Pričekajte tjedan dana te ako se simptomi poboljšaju nastavite liječenje s 25%
English: 75% dose reduction
Croatian: Smanjenje doze za 75%
English: In a phase III study comparing single-agent Myocet liposomal (75 mg/m2) versus single-agent doxorubicin (75 mg/m2), 12% versus 27% of patients, respectively developed a significant decrease in LVEF.
Croatian: ispitivanju faze III koje je uspoređivalo samo lijek Myocet liposomal (75 mg/m2) naspram samo doksorubicina (75 mg/m2), 12% odnosno 27% bolesnika razvilo je značajno smanjenje istisne frakcije lijeve klijetke (LVEF).
English: Wait one week and if symptoms improve redose at 50% dose reduction
Croatian: Pričekajte tjedan dana te ako se simptomi poboljšaju nastavite liječenje s 50%
English: Myocet liposomal must be reconstituted and further diluted prior to administration.
Croatian: Način primjene Myocet liposomal se mora rekonstituirati i dalje razrijediti prije primjene.
English: The resulting reconstituted preparation of Myocet liposomal contains 50 mg of doxorubicin HCl/25 ml of concentrate for liposomal dispersion for infusion (2 mg/ml).
Croatian: Konačni rekonstituirani pripravak Myocet liposomal sadrži 50 mg doksorubicin HCl/25 ml koncentrata za liposomsku disperziju za infuziju (2 mg/ml).
English: Myocet liposomal buffer
Croatian: Myocet liposomal pufer
English: Type I glass vials sealed with grey butyl rubber stoppers and orange flip-off aluminium seals, containing 50 mg of doxorubicin HCl lyophilised powder.
Croatian: I zatvorene sivim čepovima od butilne gume i narančastim aluminijskim poklopcima koje sadrže 50 mg liofiliziranog praška doksorubicin HCl.
English: Powder, dispersion and solvent for concentrate for dispersion for infusion
Croatian: Prašak, disperzija i otapalo za koncentrat za disperziju za infuziju
English: Pharmaco-therapeutic group: Antineoplastic agents, anthracyclines and related substances, ATC code: L01DB01
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: Antineoplastični lijekovi, antraciklini i srodne tvari, ATK oznaka:
English: Liposomalencapsulated doxorubicin compared with conventional doxorubicin was not found more active in doxorubicin resistant cell lines in vitro.
Croatian: Nije nađeno da je liposomima enkapsulirani doksorubicin aktivniji od standardnog doksorubicina u linijama stanica koje su bile otporne na doksorubicin in vitro.
English: The resulting reconstituted preparation of Myocet liposomal contains 50 mg of doxorubicin HCl/25 ml of liposomal dispersion (2 mg/ml).
Croatian: Konačni rekonstituirani pripravak lijeka Myocet liposomal sadrži 50 mg doksorubicin HCl/25 ml liposomske disperzije (2 mg/ml).
English: Remove the carton of constituents from the refrigerator.
Croatian: Izvadite iz hladnjaka kutiju sa sastojcima.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Outer carton (2 sets of 3 constituents)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Vanjsko pakiranje (2 kompleta od 3 sastojka)
English: After reconstitution the finished product must be further diluted in 0.9% (w/v) sodium chloride solution for injection, or 5% (w/v) glucose solution for injection to a final volume of 40 ml to 120 ml per 50 mg reconstituted Myocet liposomal so that a final concentration of 0.4 mg/ml to 1.2 mg/ml doxorubicin is obtained.
Croatian: Nakon rekonstitucije konačni lijek treba dalje razrijediti u 0,9%-tnom otopini natrijeva klorida za injekciju ili u 5%-tnoj (w/v) glukoze za injekciju do konačnog volumena od 40 ml do 120 ml po 50 mg rekonstituiranog lijeka Myocet liposomal tako da se može postići konačna koncentracija od
English: For dose reduction of Myocet liposomal due to liver function impairment, see section 4.2.
Croatian: Za smanjenje doze lijeka Myocet liposomal zbog oštećenja jetre vidjeti dio 4.2. Kardiološka toksičnost
English: Liposome-encapsulated doxorubicin-citrate complex corresponding to 50 mg doxorubicin hydrochloride (HCl).
Croatian: Kompleks doksorubicin-citrat inkapsuliran u liposome koji odgovara 50 mg doksorubicinklorida (HCl).
English: How to store Myocet liposomal
Croatian: Kako čuvati Myocet liposomal
English: Once the content of the vials has been mixed together the resulting liposomal dispersion is orange-red and opaque.
Croatian: Kad se sadržaj bočica zajedno pomiješa, dobije se narančastocrvena i neprozirna disperzija liposoma.
English: Inject into the buffer vial to adjust the pH of liposomes.
Croatian: Injicirajte liposome u bočicu s puferom kako biste podesili pH liposoma.
English: Radiation therapy
Croatian: Liječenje zračenjem
English: Signs may include: - increased bruising - sore mouth, throat or mouth ulcers - reduced resistance to infection or fever - feeling tired or dizzy, having a lack of energy.
Croatian: - smanjena otpornost na infekciju ili vrućicu - osjećaj umora ili vrtoglavice, manjak energije.
English: Increased hepatic transaminases
Croatian: Poremećaji jetre i žuči porast jetrenih transaminaza
English: • muscle aches, back pain, headache
Croatian: • bolovi u mišićima, bol u leđima, glavobolja
English: All parenteral medicinal products should be inspected visually for particulate matter and discoloration prior to administration.
Croatian: Sve parenteralne lijekove treba prije primjene vizualno pregledati na prisutnost čestica i promjenu boje.
English: The active substance in Myocet liposomal is doxorubicin HCl.
Croatian: L01DB01 Djelatna tvar u lijeku Myocet liposomal je doksorubicin HCl.
English: - The active substance is liposome-encapsulated doxorubicin.
Croatian: - Djelatna tvar je doksorubicin enkapsuliran u liposome.
English: Reconstitute doxorubicin HCl
Croatian: 2. korak Rekonstituirajte doksorubicin HCl
English: A meta-analysis showed a statistically significant lower rate of grade 4 neutropenia (RR = 0.82, p=0.005) in patients treated with Myocet liposomal versus conventional doxorubicin.
Croatian: Metaanaliza je pokazala statistički značajno nižu stopu neutropenije 4. stupnja (RR = 0,82, p=0,005) u bolesnika liječenih lijekom Myocet liposomal naspram standardnog doksorubicina.
English: Doxorubicin is known to be eliminated in large part by the liver.
Croatian: Utvrđeno je da se doksorubicin uvelikom opsegu eliminira u jetri.
English: • Using a syringe, withdraw the entire vial contents of pH-adjusted liposomes from the buffer vial.
Croatian: • Koristeći se štrcaljkom izvucite cijeli sadržaj liposoma s podešenim pH iz bočice pufera.
English: • feeling tired, dizzy or light-headed.
Croatian: • osjećaj umora, vrtoglavice ili omaglice.
English: Therapy with Myocet liposomal causes myelosuppression.
Croatian: Liječenje lijekom Myocet liposomal uzrokuje mijelosupresiju.
English: Myocet liposomal consists of a powder, dispersion and solvent for concentrate for dispersion for infusion.
Croatian: Myocet liposomal se sastoji od praška, disperzije i otapala za koncentrat za disperziju za infuziju.
English: 50% dose reduction
Croatian: Smanjenje doze za 50%
English: Pleural effusion
Croatian: Često pruritus folikulitis
English: Injection site reaction
Croatian: Reakcije na mjestu davanja injekcije
English: If using a water bath, heat the doxorubicin HCl vial with the thermometer temperature reading 55°C-60°C for 10 minutes (not to exceed 15 minutes).
Croatian: Ako upotrebljavate vodenu kupelj, zagrijavajte bočicu doksorubicin HCl-a s termometrom koji očitava temperaturu 55°C-60°C tijekom 10 minuta (ne dulje od 15 minuta).
English: Women of childbearing potential should use an effective contraceptive during treatment with Myocet liposomal and up to 6 months following discontinuation of therapy.
Croatian: Žene reproduktivnog potencijala trebaju koristiti djelotvornu kontracepciju tijekom liječenja lijekom
English: Myocet liposomal contains sodium
Croatian: Myocet liposomal sadrži natrij
English: STICKER/TEAR OFF SECTION OF LABEL FOR RELABELLING THE DOXORUBICIN HCL VIAL CONTAINING RECONSTITUTED FINISHED CONCENTRATE FOR DISPERSION FOR INFUSION
Croatian: DOKSORUBICIN HCL-a KOJA SADRŽI REKONSTITUIRANI GOTOVI KONCENTRAT ZA DISPERZIJU ZA INFUZIJU
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS LIPOSOMES
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE LIPOSOMI
English: Congestive cardiac failure
Croatian: Često kongestivno zatajenje srca
English: Caution should be exercised in the handling and preparation of Myocet liposomal.
Croatian: Prilikom pripreme i rukovanja lijekom Myocet liposomal treba biti oprezan.
English: Doxorubicin may exert its antitumour and toxic effects by a number of mechanisms including inhibition of topoisomerase II, intercalation with DNA and RNA polymerases, free radical formation and membrane binding.
Croatian: Doksorubicin može iskazivati svoje antitumorske i toksične učinke brojnim mehanizmima koji uključuju inhibiciju topoizomeraze II,
English: Myocet liposomal 50 mg powder, dispersion and solvent for concentrate for dispersion for infusion.
Croatian: Myocet liposomal 50 mg prašak, disperzija i otapalo za koncentrat za disperziju za infuziju.
English: • If using a water bath, heat the doxorubicin HCl vial with the thermometer temperature reading 55°C-60°C for 10 minutes (not to exceed 15 minutes).
Croatian: • Ako upotrebljavate vodenu kupelj, zagrijavajte bočicu doksorubicin HCl-a s termometrom koji očitava temperaturu 55°C-60°C tijekom 10 minuta (ne dulje od 15 minuta).
English: Liposome-encapsulated doxorubicin corresponding to 50 mg doxorubicin hydrochloride
Croatian: Doksorubicin enkapsuliran u liposome koji odgovara 50 mg doksorubicinklorida.
English: • Remove the carton of constituents from the refrigerator.
Croatian: • Izvadite iz hladnjaka kutiju sa sastojcima.
English: Cardiac disorders
Croatian: Srčani poremećaji aritmija
English: Vial 2 - liposomes is a white to off-white, opaque and homogeneous dispersion.
Croatian: bočica 1 - doksorubicin HCl je crveni liofilizirani prašak. bočica 2 - liposomi su bijela do bjelkasta, neprozirna i homogena disperzija. bočica 3 - pufer je bistra bezbojna otopina.
English: 3.1 Preparation of Myocet liposomal
Croatian: 3.1 Priprema lijeka Myocet liposomal
English: All parenteral solutions should be inspected visually for particulate matter and discoloration prior to administration.
Croatian: Sve parenteralne otopine treba prije primjene vizualno pregledati na prisutnost čestica i promjenu boje.
English: Vial 1 - doxorubicin HCl
Croatian: Bočica 1 - doksorubicin HCl
English: Doxorubicin is metabolised largely by the liver and excreted in the bile.
Croatian: Doksorubicin se metabolizira uvelike u jetri te se izlučuje putem žuči.
English: • change in how often you pass water (urine), pain on passing water or blood in your urine
Croatian: • promjena u učestalosti mokrenja, bol pri mokrenju ili krv u mokraći.
English: A meta-analysis showed a statistically significant lower rate of nausea/vomiting grade ≥ 3 (RR = 0.65, p=0.04) and diarrhoea grade ≥ 3(RR = 0.33, p=0.03) in patients treated with Myocet liposomal versus conventional doxorubicin.
Croatian: p=0,04) i proljeva ≥ 3. stupnja (RR = 0,33, p=0,3) u bolesnika liječenih lijekom Myocet liposomal naspram standardnog doksorubicina.
English: Increased serum bilirubin
Croatian: Često povećana alkalna fosfataza žutica povećan serumski bilirubin
English: Infections and infestations
Croatian: Infekcije i infestacije neutropenijska vrućica
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS BUFFER
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE PUFER
English: Nadir ANC (cells/µl)
Croatian: Najniži ABN (stanice/µl)
English: Myocet liposomal 50 mg powder, dispersion and solvent for concentrate for dispersion for infusion Liposomal doxorubicin hydrochloride
Croatian: Myocet liposomal 50 mg prašak, disperzija i otapalo za koncentrat za disperziju za infuziju liposomski doksorubicinklorid
English: Stomatitis/mucositis
Croatian: Vrlo često stomatits/mukozitis
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS DOXORUBICIN HCL VIAL
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE BOČICA DOKSORUBICIN HCL-a
English: Psychiatric disorders
Croatian: Psihijatrijski poremećaji agitacija
English: Nausea/vomiting
Croatian: Poremećaji probavnog sustava mučnina/povraćanje
English: Careful haematological monitoring (including white blood cell and platelet count, and haemoglobin) should be performed during therapy with Myocet liposomal.
Croatian: Tijekom terapije lijekom Myocet liposomal treba provoditi pažljivi hematološki nadzor (uključujući broj leukocita i trombocita te hemoglobin).
English: • shortness of breath, swollen ankles, muscle cramps.
Croatian: • osjećaj žeđi, bol ili oticanje jednjaka • nedostatak zraka, natečeni gležnjevi, grčevi u mišićima.
English: Analyses of cardiotoxicity in clinical trials have shown a statistically significant reduction in cardiac events in patients treated with Myocet liposomal compared to patients treated with conventional doxorubicin at the same dose in mg. A meta-analysis showed a statistically significant lower rate of both clinical heart failure (RR = 0.20, p=0.02) and clinical and subclinical heart failure combined (RR = 0.38, p<0.0001) in patients treated with Myocet liposomal versus conventional doxorubicin.
Croatian: Analize kardiotoksičnosti u kliničkim ispitivanjima pokazale su statistički značajno smanjenje srčanih događaja u bolesnica liječenih lijekom Myocet liposomal u usporedbi s bolesnicama liječenim standardnim doksorubicinom u istoj dozi lijeka u mg.
English: Adjust pH of liposomes
Croatian: 4. korak Podesite pH liposoma
English: Myocet liposomal 50 mg concentrate for dispersion for infusion Liposomal doxorubicin HCl
Croatian: Myocet liposomal 50 mg koncentrat za disperziju za infuziju. liposomski doksorubicin HCl i.v.
English: Package leaflet: Information for the user Myocet liposomal 50 mg powder, dispersion and solvent for concentrate for dispersion for infusion
Croatian: Uputa o lijeku: Informacija za korisnika Myocet liposomal 50 mg prašak, disperzija i otapalo za koncentrat za disperziju za infuziju liposomski doksorubicinklorid