FrancophonIA/ELRC3.0 huggingface dataset:
English: Sympathomimetic agents: Amitriptyline may potentiate the cardiovascular effects of adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, and phenylpropanolamine (e.g. as contained in local and general anaesthetics and nasal decongestants).
Maltese: Amitriptyline jista' jsaħħaħ l-effetti kardjovaskulari ta' adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, u phenylpropanolamine (eż. kif jinsabu f'anestetiċi lokali u ġenerali u dekonġestjonanti tal-imnieħer).
English: Cytochrome P450 inhibitors of CYP2D6
Maltese: Inibituri ta' CYP2D6 taċ-ċitokroma P450
English: • Migraine prophylaxis
Maltese: • Profilassi tal-emigranja
English: • diarrhoea, vomiting
Maltese: Madankollu, fluvoxamine
English: Unless prescribed otherwise, adult patients receive 1 ampoule Saroten 2 ml (50 mg amitriptyline hydrochloride) in 250 to 500 ml sodium chloride solution 0.9% for 2-3 hours as a drip infusion under control of blood pressure and ECG.
Maltese: Sakemm ma jkunx preskritt mod ieħor, pazjenti adulti jirċievu ampulla waħda ta' Saroten 2 ml (50 mg amitriptyline hydrochloride) f'250 sa 500 ml ta' soluzzjoni ta' 0.9% sodium chloride għal 2-3 sigħat bħala infużjoni permezz ta' drip taħt kontroll tal-pressjoni u ECG.
English: Major depressive disorder
Maltese: disturbi depressivi.
English: • convulsions
Maltese: • konvulżjonijiet
English: Patients with special risks
Maltese: Pazjenti b'riskji speċjali
English: If possible, discontinue this medicinal product several days before surgery; if emergency surgery is unavoidable, the anaesthetist should be informed that the patient is being so treated.
Maltese: Jekk possibbli, waqqaf dan il-prodott mediċinali diversi jiem qabel il-kirurġija; jekk ma tistax tiġi evitata kirurġija ta' emerġenza, l-anestetista għandu jiġi mgħarraf dwar it-trattament li jkun qed jirċievi l-pazjent.
English: 6.1 List of excipients [To be completed nationally]
Maltese: 6.1 Lista ta' eċċipjenti
English: The estimated daily infant exposure (amitriptyline + nortriptyline) averages 2% of the corresponding maternal weight related doses of amitriptyline (in mg/kg) (see section 4.6).
Maltese: esponiment ta' kuljum stmat fit-trabi (amitriptyline + nortriptyline) jilħaq medja ta' 2% tad-dożi korrispondenti relatati mal-piż tal-omm ta' amitriptyline (f'mg/kg) (ara sezzjoni 4.6).
English: A meta-analysis of placebocontrolled clinical trials of antidepressant drugs in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Maltese: Meta-analiżi ta' provi kliniċi kkontrollati bil-plaċebo ta' mediċini antidepressanti f'pazjenti adulti b'disturbi psikjatriċi uriet riskju akbar ta' mġiba marbuta ma' suwiċidju b'antidepressanti meta mqabbla mal-plaċebo f'pazjenti iżgħar minn 25 sena.
English: CNS depressants: Amitriptyline may enhance the sedative effects of alcohol, barbiturates and other CNS depressants.
Maltese: Amitriptyline jista' jsaħħaħ l-effetti sedattivi ta' alkoħol, barbiturates u depressanti tas-CNS oħrajn.
English: Uncommon Hypomania, mania, anxiety, insomnia, nightmare.
Maltese: Ipomanija, manija, ansjetà, insomnja, ħmar il-lejl.
English: Information from clinical trials has shown an increased risk of suicidal behaviour in young adults (less than 25 years old) with psychiatric conditions who were treated with an antidepressant.
Maltese: Informazzjoni minn provi kliniċi wriet żieda fir-riskju ta' mġiba suwiċidali f'adulti żgħażagħ (ta' età inqas minn 25 sena) b'kondizzjonijiet psikjatriċi li kienu ittrattati b'antidepressanti.
English: The product information may be subsequently updated by the Member State competent authorities, in liaison with the reference Member State, as appropriate, in accordance with the procedures laid down in Chapter 4 of Title III of Directive 2001/83/EC.
Maltese: L-informazzjoni tal-prodott tista' tiġi aġġornata sussegwentement mill-awtoritajiet kompetenti talIstati Membri, flimkien mal-Istat Membru ta' Referenza, kif xieraq, b'konformità mal-proċeduri stabbiliti f'Kapitolu 4 ta' Titolu III tad-Direttiva 2001/83/KE
English: • intestinal blockage
Maltese: Disturbi gastro-intestinali
English: • hepatitis
Maltese: - epatite
English: • medicines to treat irregular heartbeats (e.g. quinidine and sotalol)
Maltese: • mediċini biex jittrattaw taħbit irregolari tal-qalb (eż. quinidine u sotalol)
English: • methylphenidate (used to treat ADHD)
Maltese: • methylphenidate (użat għat-trattament ta' ADHD) • ritonavir (użat għat-trattament tal-HIV)
English: The antidepressant effect usually sets in after 2-4 weeks; the sedative action is not delayed.
Maltese: L-effetti antidepressanti normalment jibdew wara 2-4 ġimgħat; l-azzjoni sedattiva ma ddumx ma tibda.
English: This risk persists until significant remission occurs.
Maltese: Dan ir-riskju jippersisti sakemm isseħħ remissjoni sinifikanti.
English: Adrenergic neurone blockers: Tricyclic antidepressants may counteract the antihypertensive effects of centrally acting antihypertensives such as guanethidine, betanidine, reserpine, clonidine and methyldopa.
Maltese: Imblokkaturi adrenerġiċi tan-newroni: Antidepressanti triċikliċi jistgħu jinnewtralizzaw l-effetti kontra l-pressjoni għolja ta' sustanzi kontra l-pressjoni għolja li jaġixxu b'mod ċentrali bħal guanethidine, betanidine, reserpine, clonidine u methyldopa.
English: Electrolyte disturbances (hypokalaemia, hyperkalaemia, hypomagnesaemia) are known to be conditions increasing the proarrythmic risk.
Maltese: Disturbi fl elettroliti (ipokalimja, iperkalimja, ipomanjesimja) huma magħrufa li huma kondizzjonijiet li jżidu r riskju ta' proarritmija.
English: All the metabolites have less anticholinergic activity than amitriptyline and nortriptyline.
Maltese: Il-metaboliti kollha għandhom attività antikolinerġika aktar baxxa minn amitriptyline u nortriptyline.
English: In the listing below the following convention is used: MedDRA system organ class / preferred term Very common (> 1/10);
Maltese: Klassi tas-sistemi u tal-organi MedDRA / terminu ppreferut;
English: • the prophylactic treatment of migraine in adults
Maltese: • it-trattament profilattiku tal-emigranja fl-adulti
English: Ingestion of 750 mg or more by an adult may result in severe toxicity.
Maltese: Inġestjoni ta' 750 mg jew aktar minn persuna adulta tista' twassal għal tossiċità severa.
English: Use caution when using amitriptyline and methadone concomitantly due to a potential for additive effects on the QT interval and increased risk of serious cardiovascular effects.
Maltese: Għandu jkun hemm kawtela meta amitriptyline jintuża flimkien ma' methadone minħabba potenzjal ta' effetti addittivi fuq l-intervall QT u riskju akbar ta' effetti kardjovaskulari serji.
English: Not known Extrapyramidal disorder.
Maltese: Mhux magħrufa Disturb ekstrapiramidali.
English: The mean systemic clearance (Cls) is 39.24±10.18 L/h, range 24.53-53.73 L/h.
Maltese: It-tneħħija sistemika medja (Cls) hija 39.24±10.18 L/siegħa, firxa 24.53 - 53.73 L/siegħa.
English: Perform electrocardiograph-look for QRS>0.16 seconds 4.
Maltese: Wettaq elettrokardjograf-iċċekkja għal QRS ta'>0.
English: Uncommon Tinnitus.
Maltese: Tomgħodomx.
English: • An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome
Maltese: • Qabel ma tinbeda t-terapija b'amitriptyline għandu jsir ECG biex jiġi eskluż syndrome ta' QT
English: Secure an IV access.
Maltese: Stabilixxi aċċess IV.
English: Other metabolites such as cis- and trans-10-hydroxyamitriptyline and cis- and trans-10-hydroxynortriptyline have the same profile as nortriptyline but is considerably weaker.
Maltese: Metaboliti oħra bħal ċis u trans-10-hydroxyamitriptyline u cis- u trans-10-hydroxynortriptyline għandhom l-istess profil bħal nortriptyline, iżda huma ħafna aktar dgħajfa.
English: The antidepressant and analgesic effects usually set in after 2-4 weeks; the sedative action is not delayed.
Maltese: L-effett anti-depressant normalment jibda wara 2-4 ġimgħat; l-azzjoni sedattiva mhix ittardjata.
English: These should not be taken at the same time as Saroten Retard (see section 2 Do not take X) adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (these may be present in cough or cold medicine, and in some anaesthetics) medicine to treat high blood pressure for example calcium-channel blockers (e.g. diltiazem and verapamil), guanethidine, betanidine, clonidine reserpine and methyldopa anticholinergics such as certain medicines to treat Parkinsons disease and gastrointerstinal disorders (e.g. atropine, hyoscyamine) thioridazine (used to treat schizophrenia) tramadol (painkiller) medicines to treat fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole) sedatives (e.g. babiturates) antidepressants (e.g SSRIs fluoxetine, paroxetine, fluvoxamine and bupropion) medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics) cimetidine (used to treat stomach ulcers) methylphenidate (used to treat ADHD) ritonavir (used to treat HIV) oral contraceptives rifampicin (to treat infections) phenytoin and carbamazepine (used to treat epilepsy) St. John´s Wort (hypericum perforatum) - a herbal remedy used for depression thyroid medication
Maltese: Mhux komuni: jistgħu jaffettwaw sa persuna waħda minn kull 100 persuna eċitament, ansjetà, diffikultajiet biex torqod, ħmar il-lejl konvulżjonijiet żarżir fil-widnejn żieda fil-pressjoni tad-demm dijarea, rimettar raxx tal-ġilda, ħorriqija (urtikarja), nefħa fil-wiċċ u l-ilsien diffikultajiet biex tgħaddi l-awrina żieda fil-produzzjoni tal-ħalib tas-sider jew ħruġ tal-ħalib tas-sider mingħajr treddigħ żieda fil-pressjoni fil-boċċa tal-għajn kondizzjonijiet ta' kollass aggravar ta' insuffiċjenza tal-qalb indeboliment fil-funzjoni tal-fwied (eż., marda kolestatika tal-fwied).
English: • tramadol (painkiller)
Maltese: • tramadol (mediċina għall-uġigħ)
English: Potential of other medicinal products to affect amitriptyline
Maltese: Potenzjal ta' prodotti mediċinali oħrajn li jaffettwaw amitriptyline
English: Cardiac disorders
Maltese: insuffiċjenza kardijaka.
English: Potential of other medicinal products to affect amitriptyline Tricyclic antidepressants (TCA) including amitriptyline are primarily metabolised by the hepatic cytochrome P450 isozymes CYP2D6 and CYP2C19, which are polymorphic in the population.
Maltese: Potenzjal ta' prodotti mediċinali oħrajn li jaffettwaw amitriptyline Antidepressanti triċikliċi (TCA - tricyclic antidepressants) inkluż amitriptyline huma primarjament metabolizzati mill-isozimi taċ-ċitokroma P450 tal-fwied, CYP2D6 u CYP2C19, li huma polimorfiċi fil-popolazzjoni.
English: The solution for infusion prepared with sodium chloride solution 0.9% must be used immediately.
Maltese: Is-soluzzjoni għallinfużjoni ppreparata b'soluzzjoni ta' 0.9% sodium chloride għandha tintuża minnufih.
English: Prolonged QT interval A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG) and heart rhythm disorders (rapid or irregular heart beat) have been reported with X. Tell your doctor if you:
Maltese: Problema fil-qalb imsejjħa “intervall ta' QT imtawwal” (li tidher fuq l-elettrokardjogramm tiegħek, ECG) u disturbi fir-ritmu tal-qalb (taħbit mgħaġġel jew irregolari tal-qalb) kienu rrappurtati b'X.
English: After reduction of the depressive symptoms the treatment with amitriptyline should be continued for up to 6 month.
Maltese: Wara t-tnaqqis tas-sintomi depressivi t-trattament b'amitriptyline għandu jitkompla sa 6 xhur.
English: • medicine to treat high blood pressure for example calcium-channel blockers (e.g. diltiazem and verapamil), guanethidine, betanidine, clonidine reserpine and methyldopa
Maltese: diltiazem u verapamil), guanethidine, betanidine, clonidine reserpine u methyldopa
English: X belongs to a group of medicines known as tricyclic antidepressants.
Maltese: X jagħmel parti minn grupp ta' mediċini magħrufa bħala antidepressanti triċikliċi.
English: Amitriptyline is a sedative drug.
Maltese: Amitriptyline huwa mediċina sedattiva.
English: As with other tricyclic antidepressants, amitriptyline should not be given to patients receiving monoamine oxidase inhibitors (MAOIs).
Maltese: Bħal b'antidepressanti triċikliċi oħra, amitriptyline m'għandux jingħata lill-pazjenti li jkunu qed jirċievu inibituri ta' monoamine oxidase (MAOIs - monoamine oxidase inhibitors).
English: • pylorus stenosis (narrowing of the gastric outlet) and paralytic ileus (blocked intestine)
Maltese: • stenosi tal-piloru (l-iżbokk tal-istonku jidjied) u ileus paralitiku (imblokk tal-musrana)
English: Tricyclic antidepressants (TCA) including amitriptyline are primarily metabolised by the hepatic cytochrome P450 isozymes CYP2D6 and CYP2C19, which are polymorphic in the population.
Maltese: Antidepressanti triċikliċi (TCA - tricyclic antidepressants) inkluż amitriptyline huma primarjament metabolizzati mill-isozimi taċ-ċitokroma P450 tal-fwied, CYP2D6 u CYP2C19, li huma polimorfiċi fil-popolazzjoni.
English: Treatment is symptomatic and supportive.
Maltese: It-trattament huwa sintomatiku u ta'
English: Due to the often delayed gastrointestinal tract passage maximum plasma concentrations are reached after 1 to 5 (-8) hours.
Maltese: Minħabba passaġġ mill-apparat gastrointestinali li ħafna drabi jkun ittardjat il-konċentrazzjonijiet massimi fil-plażma jintlaħqu wara 1 sa 5 (-8) sigħat.
English: • Anticholinergic drugs such as certain medicines to treat Parkinsons disease and gastrointerstinal disorders (e.g. atropine, hyoscyamine)
Maltese: • mediċini antikolinerġiċi bħal ċerti mediċini biex jittrattaw il-marda ta' Parkinsons u disturbi gastrointestinali (eż. atropine, hyoscyamine)
English: Depending on individual patient response, a lower dose of amitriptyline should be considered if a strong CYP2D6 inhibitor (e.g. bupropion, quinidine, fluoxetine, paroxetine) is added to amitriptyline treatment (see section 4.5).
Maltese: Skont ir-rispons tal-pazjent individwali, għandha tiġi kkunsidrata doża aktar baxxa ta' amitriptyline jekk inibitur qawwi ta' CYP2D6 (eż. bupropion, quinidine, fluoxetine, paroxetine) jiżdied mat trattament b'amitriptyline (ara sezzjoni 4.5).
English: Drugs which prolong the QT-interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide and sertindole), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants.
Maltese: Mediċini li jtawlu l-intervall QT inklużi antiarritmiċi bħal quinidine, l-antistamini astemizole u terfenadine, xi antipsikotiċi (notevolment pimozide u sertindole), cisapride, halofantrine, u sotalol,
English: The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps.
Maltese: Għalhekk iddożaġġ jista' jiżdied f'żidiet ta' 25 mg amitriptyline hydrochloride.
English: Symptoms of overdose include: dilated pupils fast or irregular heartbeats difficulties passing water dry mouth and tongue intestinal blockage fits fever agitation confusion hallucinations uncontrolled movements low blood pressure, weak pulse, pallor difficulty breathing blue discolouration of the skin decreased heart rate drowsiness loss of consciousness coma various cardiac symptoms such as heart block, heart failure, hypotension, cardiogenic shock, metabolic acidosis, hypokalemia.
Maltese: Sintomi ta' doża eċċessiva jinkludu: ħabbiet tal-għajnejn dilatati taħbit mgħaġġel jew irregolari tal-qalb diffikultajiet biex tgħaddi l-awrina ħalq u ilsien xotti imblokk fl-imsaren aċċessjonijiet deni aġitazzjoni konfużjoni alluċinazzjonijiet movimenti mhux ikkontrollati pressjoni baxxa tad-demm, polz dgħajjef, sfurija diffikultà biex tieħu n-nifs lewn ikħal tal-ġilda rata tal-qalb imnaqqsa ngħas tintilef minn sensik koma diversi sintomi kardijaċi bħal imblokk tal-qalb, insuffiċjenza tal-qalb, pressjoni baxxa, xokk kardjoġeniku, aċidożi metabolika, ipokalimja.
English: Not known: frequency cannot be estimated from the available data absent sensation of appetite elevation or lowering of blood sugar levels paranoia movement disorders (involuntary movements or decreased movements) hypersensitivity inflammation of heart muscle hepatitis hot flush injection site reactions
Maltese: - nuqqas ta' sensazzjoni ta' aptit - livelli elevati jew imnaqqsa ta' zokkor fid-demm - paranojja - disturbi fil-moviment (movimenti involontarji jew movimenti mnaqqsa)
English: This condition may be signs of acute glaucoma.
Maltese: Din il-kondizzjoni tista' tkun sinjal ta' glawkoma akuta.
English: • sexual disturbances (decreased sex-drive, problems with erection)
Maltese: • disturbi sesswali (tnaqqis fil-ġibda għas-sess, problemi bl-erezzjoni)
English: X contains sodium This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially ‘sodium- free'.
Maltese: Dan il-prodott mediċinali fih anqas minn 1 mmol sodium (23 mg) f'kull doża, jiġifieri essenzjalment
English: In reproductive studies teratogenic effects were not observed in mice, rats, or rabbits when amitriptyline was given orally at doses of 2-40 mg/kg/day (up to 13 times the maximum recommended human amitriptyline dose of 150 mg/day or 3 mg/kg/day for a 50-kg patient).
Maltese: Fi studji dwar l-effett fuq is-sistema riproduttiva ma ġewx osservati effetti teratoġeniċi fil-ġrieden, firien, jew fniek meta amitriptyline ingħata mill-ħalq f'dożi ta' 2 - 40 mg/kg/jum (sa 13-il darba ddoża massima rakkomandata ta' amitriptyline fil-bniedem ta' 150 mg/jum jew 3 mg/kg/jum għal pazjent ta' 50 kg).
English: • schizophrenia
Maltese: • skiżofrenja
English: The efficacy and safety of amitriptyline (as solution for injection) has been demonstrated for the indication Major Depressive Disorder.
Maltese: L-effikaċja u s-sigurtà ta' amitriptyline (bħala soluzzjoni għall-injezzjoni) intwerew għall-indikazzjoni ta' Disturb Depressiv Maġġuri.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucosegalactose malabsorption should not receive this medicine.
Maltese: Pazjenti li għandhom problemi ereditarji rari ta' intolleranza għall-galactose, defiċjenza ta' Lapp lactase jew malassorbiment tal-glucose-galactose m'għandhomx jieħdu din il-mediċina.
English: Akathisia, polyneuropathy.
Maltese: Akatiżja, polinewropatija.
English: It has marked anticholinergic and sedative properties.
Maltese: Għandu kwalitajiet antikolinerġiċi u sedattivi ċari.
English: Do not use this medicine after the expiry date which is stated on the label afterr EXP.
Maltese: Tużax din il-mediċina wara d-data ta' meta tiskadi li tidher fuq it-tikketta wara EXP.
English: • particular forms of abnormal heart rhythm (so called torsades de pointes)
Maltese: • forom partikulari ta' ritmu tal-qalb mhux normali (li jissejjaħ torsades de pointes)
English: • the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products.
Maltese: • it-trattament ta' enuresi matul il-lejl fi tfal b'età minn 6 snin 'il fuq meta patoloġija organika, inkluża spina bifida u disturbi relatati, tkun ġiet eskluża u ma jkunx inkiseb rispons għall-ebda trattament mhux mediċinali u mediċinali, inklużi antispasmodiċi u prodotti relatati ma' vasopressin.
English: Unrest and convulsions may be treated with diazepam.
Maltese: Irrekwitezza u konvulżjonijiet jistgħu jiġu ttrattati b'diazepam.
English: <[Saroten and associated names 10 mg film-coated tablets; Saroten and associated names 25 mg filmcoated tablets; Saroten and associated names 25 mg prolonged-release capsules, hard; Saroten and associated names 50 mg prolonged-release capsules, hard; Saroten and associated names 50 mg filmcoated tablets]
Maltese: <[Saroten u ismijiet assoċjati 10 mg pilloli miksija b'rita; Saroten u ismijiet assoċjati 25 mg pilloli miksija b'rita; Saroten u ismijiet assoċjati 25 mg kapsuli li jerħu l-mediċina bil-mod, iebsin; Saroten u ismijiet assoċjati 50 mg kapsuli li jerħu l-mediċina bil-mod, iebsin; Saroten u ismijiet assoċjati 50 mg pilloli miksija b'rita biss] Amitriptyline>
English: The effects in overdose will be potentiated by simultaneous ingestion of alcohol and other psychotropic.
Maltese: L-effetti ta' doża eċċessiva jiġu msaħħa bl-inġestjoni simultanja ta' alkoħol u psikotropiċi oħra.
English: The mean systemic clearance (Cls) is 51.5 ±13.8 l/h, range 25.6-71.8 l/h.
Maltese: It-tneħħija sistemika (Cls - systemic clearance) medja hija 51.5±13.8 l/siegħa, firxa 25.
English: Widening of the QRS-complex usually correlates well with the severity of the toxicity following acute overdoses.
Maltese: Twessigħ tal-kumpless QRS normalment huwa kkorrelatat tajjeb mas-severità tat-tossiċità wara dożi eċċessivi akuti.
English: administration of 40-60 mg amitriptyline hydrochloride was 10.1-27.8 h and of 15 mg 15.5-19.5 h. In elderly subjects the half-life is prolonged.
Maltese: 1 - 27.8 sigħat u ta' 15 mg 15.5 - 19.5 sigħat.
English: Fever.
Maltese: Suffejra.
English: • thioridazine (used to treat schizophrenia)
Maltese: • thioridazine (jintuża biex jittratta s-skiżofrenja)
English: injection
Maltese: AMPULLA
English: NAME OF THE MEDICINAL PRODUCT Saroten and associated names 25 mg prolonged-release capsules, hard Saroten and associated names 50 mg prolonged-release capsules, hard Saroten and associated names 75 mg, modified release tablets
Maltese: Saroten u ismijiet assoċjati 25 mg kapsuli li jerħu l-mediċina bil-mod, iebsin Saroten u ismijiet assoċjati 50 mg kapsuli li jerħu l-mediċina bil-mod, iebsin Saroten u ismijiet assoċjati 75 mg, pilloli li jerħu l-mediċina b'mod modifikat
English: Elderly patients over 65 years of age and patients with cardiovascular disease Initially 10 mg - 25 mg daily.
Maltese: Pazjenti anzjani b'età ta' aktar minn 65 sena u pazjenti b'mard kardjovaskulari Inizjalment 10 mg - 25 mg kuljum.
English: Tricyclic antidepressants and neuroleptics mutually inhibit the metabolism of each other; this may lead to a lowered convulsion threshold, and seizures.
Maltese: Antidepressanti triċikliċi u newrolettiċi reċiprokament jinibixxu l-metaboliżmu ta' xulxin; dan jista' jwassal għal tnaqqis fil-limitu għall-konvulżjoni, u aċċessjonijiet.
English: Salivary gland enlargement, ileus paralytic.
Maltese: Tkabbir tal-glandola tal-bżieq, ileus paralitiku.
English: Anticholinergic symptoms: Mydriasis, tachycardia, urinary retention, dry mucous membranes, reduced bowel motility.
Maltese: Midrijasi, takikardija, żamma tal-awrina, membrani mukużi xotti, motilità tal musrana imnaqqsa.
English: The renal elimination of unchanged amitriptyline is insignificant (about 2%).
Maltese: L-eliminazzjoni renali ta' amitriptyline mhux mibdul hija insinifikanti (madwar 2%).
English: Disturbance in attention, dysgeusia.
Maltese: Konvulżjonijiet, deni.
English: Uncommon Galactorrhoea.
Maltese: Komuni ħafna Għaraq eċċessiv.
English: The recommended daily dose is 25 mg - 75 mg.
Maltese: Id-doża rakkomandata ta' kuljum hija 25 mg - 75 mg.
English: The plasma protein binding is about 95%.
Maltese: It-twaħħil mal-proteini fil-plażma huwa madwar 95%.
English: • adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (these may be present in cough or cold medicine, and in some anaesthetics)
Maltese: • adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine u phenylpropanolamine
English: Known poor metabolisers of CYP2D6 or CYP2C19
Maltese: Metabolizzaturi dgħajfa magħrufa ta' CYP2D6 jew CYP2C19
English: Assess and treat ABC's (airway, breathing and circulation) as appropriate.
Maltese: Evalwa u ttratta l-ABC's (airway, breathing and circulation [passaġġ tan-nifs, teħid tan-nifs u ċ-ċirkolazzjoni]) kif xieraq.
English: The maintenance dose is the lowest effective dose.
Maltese: Id-doża ta' manteniment hija l-inqas doża effettiva.
English: • Chronic tension type headache prophylaxis in adults
Maltese: • it-trattament ta' disturb depressiv maġġuri fl-adulti