FrancophonIA/ELRC3.0 huggingface dataset:
English: Table 1 Recommended doses for transfusional iron overload
Croatian: Tablica 1 Preporučene doze za preopterećenje željezom izazvano transfuzijama
English: In patients with non-transfusion-dependent thalassaemia syndromes, iron overload may also develop over time, mainly due to increased absorption of dietary iron in response to low blood cell counts.
Croatian: U bolesnika sa sindromima talasemije neovisnim o transfuziji s vremenom se može razviti i preopterećenost željezom, uglavnom zbog pojačane apsorpcije željeza unesenog u tijelo prehranom s obzirom na nizak broj krvnih stanica.
English: If any of these affects you severely, tell your doctor.
Croatian: Ako se bilo koja od tih nuspojava kod Vas javi u teškom obliku, obavijestite svog liječnika.
English: For patients, already well managed on treatment with deferoxamine, a starting dose of Deferasirox Mylan film-coated tablets that is numerically one third that of the deferoxamine dose could be considered (e.g. a patient receiving 40 mg/kg/day of deferoxamine for 5 days per week (or equivalent) could be transferred to a starting daily dose of 14 mg/kg/day of Deferasirox Mylan film-coated tablets).
Croatian: U bolesnika u kojih je dobra regulacija već postignuta liječenjem deferoksaminom početna doza Deferasirox Mylan filmom obloženih tableta može iznositi trećinu brojčane vrijednosti doze deferoksamina (npr. bolesnik koji prima 40 mg/kg/dan deferoksamina tijekom 5 dana na tjedan (ili ekvivalentno), može se prebaciti na početnu dnevnu dozu Deferasiroks Mylan filmom obloženih tableta od 14 mg/kg/dan).
English: >14 ml/kg/month of PRBC (approx. >4 units/month for an adult)
Croatian: > 14 ml/kg/mjesec KE-a (otprilike > 4 jedinice /mjesec za odraslu osobu)
English: Liver iron concentration (LIC)
Croatian: Filmom obložene tablete Koncentracija željeza u jetri (LIC)
English: Your doctor may require you to undergo a kidney biopsy, if he/she suspects significant kidney damage.
Croatian: Vam se napravi biopsija bubrega ukoliko sumnja na značajno oštećenje bubrega.
English: Gallstones and related biliary disorders were reported in about 2% of patients.
Croatian: Žučni kamenci i srodni poremećaji žuči prijavljeni su u oko 2% bolesnika.
English: Table 2 Recommended doses for non-transfusion-dependent thalassaemia syndromes
Croatian: Tablica 2 Preporučene doze za sindrome talasemije neovisne o transfuziji
English: - ciclosporin (used to prevent the body rejecting a transplanted organ or for other conditions, such as rheumatoid arthritis or atopic dermatitis), - simvastatin (used to lower cholesterol), - certain painkillers or anti-inflammatory medicines (e.g. aspirin, ibuprofen, corticosteroids), - oral bisphosphonates (used to treat osteoporosis), - anticoagulant medicines (used to prevent or treat blood clotting), - hormonal contraceptive agents (birth control medicines), - bepridil, ergotamine (used for heart problems and migraines), - repaglinide (used to treat diabetes), - rifampicin (used to treat tuberculosis), - phenytoin, phenobarbital, carbamazepine (used to treat epilepsy), - ritonavir (used in the treatment of HIV infection), - paclitaxel (used in cancer treatment), - theophylline (used to treat respiratory diseases such as asthma), - clozapine (used to treat psychiatric disorders such as schizophrenia), - tizanidine (used as a muscle relaxant), - cholestyramine (used to lower cholesterol levels in the blood).
Croatian: kortikosteroidi), - oralne bisfosfonate (koriste se za liječenje osteoporoze), - antikoagulantne lijekove (koriste se za sprečavanje ili liječenje krvnih ugrušaka), - hormonske kontraceptivne lijekove (lijekovi za kontrolu začeća), - bepridil, ergotamin (koristi se za liječenje srčanih problema i migrene), - repaglinid (koristi se za liječenje šećerne bolesti), - rifampicin (koristi se za liječenje tuberkuloze), - fenitoin, fenobarbital, karbamazepin (koriste se za liječenje epilepsije), - ritonavir (koristi se za liječenje HIV infekcije), - paklitaksel (koristi se za liječenje raka), - teofilin (koristi se za liječenje bolesti dišnih puteva poput astme), - klozapin (koristi se za liječenje psihijatrijskih poremećaja poput shizofrenije), - tizanidin (koristi se kao lijek za opuštanje mišića), - kolestiramin (koristi se za snižavanje razina kolesterola u krvi), - busulfan (koji se koristi kao terapija prije transplantacije radi uništavanja postojeće koštane srži prije transplantacije).
English: In a clinical study using single doses of 20 mg/kg deferasirox dispersible tablets, the average exposure was increased by 16% in subjects with mild hepatic impairment (Child-Pugh Class A) and by 76% in subjects with moderate hepatic impairment (Child-Pugh Class B) compared to subjects with normal hepatic function.
Croatian: U kliničkom ispitivanju u kojem su primijenjene jednokratne doze od 20 mg/kg deferasiroks tableta za oralnu suspenziju, prosječna izloženost je povećana za 16% u ispitanika s blagim oštećenjem jetre (Child-Pugh stadij A) i za 76% u ispitanika s umjerenim oštećenjem jetre (Child-Pugh stadij B) u usporedbi s ispitanicima s normalnom funkcijom jetre.
English: What Deferasirox Mylan looks like and contents of the pack Deferasirox Mylan is supplied as film-coated tablets.
Croatian: Kako Deferasiroks Mylan izgleda i sadržaj pakiranja Deferasiroks Mylan se isporučuje u obliku filmom obloženih tableta.
English: As a precaution, it is recommended that Deferasirox Mylan is not used during pregnancy unless clearly necessary.
Croatian: Kao mjera opreza, ne preporučuje se primjenjivati Deferasiroks Mylan tijekom trudnoće, osim ako to nije posve neophodno.
English: Proteinuria
Croatian: Proteinurija
English: Therefore, the concomitant use of deferasirox with theophylline is not recommended.
Croatian: Stoga se ne preporučuje istodobna primjena deferasiroksa s teofilinom.
English: Deferasirox promotes excretion of iron, primarily in the faeces.
Croatian: Deferasiroks pospješuje izlučivanje željeza, prvenstveno stolicom.
English: An interaction between deferasirox and other CYP1A2 substrates cannot be excluded.
Croatian: Ne mogu se isključiti interakcije između deferasiroksa i drugih supstrata CYP1A2.
English: Do not use any pack that is damaged or shows signs of tampering.
Croatian: - Ovaj lijek se ne smije upotrijebiti ako je pakiranje oštećeno ili su vidljivi znakovi otvaranja.
English: Elevations of liver transaminases greater than 2 times the baseline and 5 times the upper limit of normal were reported in 1.8% of patients.
Croatian: Povišenja jetrenih transaminaza za više od 2 puta od početnih vrijednosti odnosno za više od 5 puta od gornje granice normale prijavljena su u 1,8% bolesnika.
English: Most reports of hepatic failure involved patients with significant morbidities including pre-existing liver cirrhosis.
Croatian: Većina izvještaja o zatajenju jetre je uključivala bolesnike koji su imali ozbiljnije bolesti, uključujući već postojeću cirozu jetre.
English: Deferasirox induced similar responses in iron-overloaded patients with other anaemias.
Croatian: Deferasiroks je slične odgovore izazvao i u bolesnika s preopterećenjem željezom i ostalim anemijama.
English: Approximate tablet dimensions 12.8 mm × 6.00 mm.
Croatian: Približne dimenzije tablete 12,8 mm × 6,00 mm.
English: In two clinical studies, growth and sexual development of paediatric patients treated with deferasirox for up to 5 years were not affected (see section 4.8).
Croatian: U dva klinička ispitivanja rast i spolni razvoj pedijatrijskih bolesnika liječenih deferasiroksom u trajanju do 5 godina nije bio oštećen (vidjeti dio 4.8).
English: In paediatric patients with non-transfusion-dependent thalassaemia syndromes, dosing should not exceed 7 mg/kg.
Croatian: U pedijatrijskih bolesnika sa sindromima talasemije neovisnim o transfuziji doza ne smije prelaziti 7 mg/kg.
English: White HDPE bottle with white opaque polypropylene (PP) screw cap with aluminum seal containing 90 or 300 film-coated tablets.
Croatian: Bijela boca od polietilena visoke gustoće (HDPE) s bijelim neprozirnim polipropilenskim (PP) navojnim čepom s aluminijskim prstenom, koja sadrži 90 ili 300 filmom obloženih tableta.
English: When interruption of treatment may be necessary, treatment may be reintroduced after resolution of the rash, at a lower dose followed by gradual dose escalation.
Croatian: Ako se pokaže potrebnim prekinuti liječenje, ono se može ponovo nastaviti, nakon što osip prođe, nižom dozom koja se postupno povećava.
English: If serum ferritin falls consistently below 500 µg/l, an interruption of treatment should be considered (see section 4.4).
Croatian: Ako feritin u serumu pada dosljedno ispod 500 µg/l treba se razmotriti prekid liječenja (vidjeti dio 4.4).
English: Treatment with Deferasirox Mylan will be overseen by a doctor who is experienced in the treatment of iron overload caused by blood transfusions.
Croatian: Liječenje lijekom Deferasiroks Mylan će nadzirati liječnik iskusan u liječenju preopterećenja željezom, uzrokovanog transfuzijama krvi.
English: Diarrhoea is reported more commonly in paediatric patients aged 2 to 5 years than in older patients.
Croatian: Proljev je češće prijavljen u pedijatrijskih bolesnika u dobi od 2 do 5 godina, nego u starijih bolesnika.
English: As with other iron chelator treatment, high-frequency hearing loss and lenticular opacities (early cataracts) have been uncommonly observed in patients treated with deferasirox (see section 4.4).
Croatian: Kao i kada je riječ o liječenju ostalim kelatorima željeza, gubitak sluha u području visokih frekvencija i zamućenja leće (rani stadij katarakte) su manje često opaženi u bolesnika liječenih deferasiroksom (vidjeti dio 4.4).
English: For deferasirox film-coated tablets, a dose ratio of 3:1 can be considered (i.e. a dose of deferasirox film-coated tablets that is numerically one third of the deferoxamine dose).
Croatian: Za deferasiroks filmom obložene tablete može se razmotriti omjer doza 3:1 (tj. doza deferasiroks filmom obloženih tableta koja iznosi trećinu brojčane vrijednosti doze deferoksamina).
English: • 28 mg per kilogram body weight for patients receiving regular blood transfusions,
Croatian: • 28 mg po kilogramu tjelesne težine za bolesnike koji primaju redovite transfuzije krvi,
English: Monthly
Croatian: Mjesečno
English: Limited clinical data (29 patients with normal cardiac function at baseline) using MRI indicate that treatment with deferasirox 10 - 30 mg/kg/day (dispersible tablet formulation) for 1 year may also reduce levels of iron in the heart (on average, MRI T2* increased from 18.3 to 23.0 milliseconds).
Croatian: Ograničeni klinički podaci (29 bolesnika s normalnom funkcijom srca prije početka liječenja) dobiveni pomoću magnetske rezonancije (MRI) upućuju na zaključak da liječenje deferasiroksom u dozama od 10 - 30 mg/kg/dan (formulacija tablete za oralnu suspenziju) tijekom 1 godine može također smanjiti razine željeza u srcu (prosječno povećanje MRI T2* s 18,3 na 23,0 milisekunde).
English: Pancytopenia
Croatian: pancitopenija
English: Starting dose
Croatian: Početna doza
English: Deferasirox has low affinity for zinc and copper, and does not cause constant low serum levels of these metals.
Croatian: Afinitet deferasiroksa za cink i bakar je slab te ne uzrokuje stalno niske razine tih metala u serumu.
English: Particular attention should therefore be paid to monitoring of serum creatinine in patients who are concomitantly receiving medicinal products that depress renal function, and in patients who are receiving high doses of deferasirox and/or low rates of transfusion (<7 ml/kg/month of packed red blood cells or <2 units/month for an adult).
Croatian: Stoga treba obratiti posebnu pozornost na praćenje serumskog kreatinina u bolesnika koji istodobno primaju lijekove koji smanjuju bubrežnu funkciju te u bolesnika koji primaju visoke doze deferasiroksa i/ili manju količinu transfuzija (< 7 ml/kg/mjesec koncentrata eritrocita ili < 2 jedinice/mjesec u odraslih).
English: In patients not adequately controlled with doses of 21 mg/kg (e.g. serum ferritin levels persistently above 2,500 µg/l and not showing a decreasing trend over time), doses of up to 28 mg/kg may be considered.
Croatian: U bolesnika neodgovarajuće kontrolirani dozama od 21 mg/kg (tj. razine feritina u serumu su stalno iznad 2500 µg/l i ne pokazuju trend opadanja tijekom vremena) može se razmotriti primjena doza do 28 mg/kg.
English: As a consequence, Deferasirox Mylan therapy should be closely monitored to detect adverse reactions and to follow iron burden in the paediatric population.
Croatian: Zbog toga je terapiju lijekom Deferasiroks Mylan u pedijatrijskoj populaciji potrebno pažljivo pratiti kako bi se otkrile nuspojave i pratilo opterećenje željezom.
English: Deferasirox Mylan is available in clear, transparent PVC/PVdC /aluminium blister packs containing 30 or 90 film-coated tablets, in unit dose blister pack of 30 tablets and in white, plastic bottles with white opaque screw cap with aluminium seal containing 90 and 300 tablets.
Croatian: Deferasiroks Mylan dostupan je u prozirnim, bezbojnim PVC/PVdC/aluminij blisterima koji sadrže 30 ili 90 filmom obloženih tableta, u blisterima djeljivim na jedinične doze s 30 tableta i u bijelim, plastičnim bocama s bijelim neprozirnim navojnim čepom s aluminijskim prstenom, koje sadrže 90 i 300 tableta.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: Ažurirani RMP treba dostaviti: - na zahtjev Europske agencije za lijekove; - prilikom svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: Changes in weight of paediatric patients over time must be taken into account when calculating the dose.
Croatian: Pri izračunavanju doze mora se uzeti u obzir promjena tjelesne težine pedijatrijskih bolesnika tijekom vremena.
English: Interaction with midazolam and other agents metabolised by CYP3A4
Croatian: Interakcija s midazolamom i drugim lijekovima koji se metaboliziraju putem CYP3A4
English: There have been reports of ulcers complicated with digestive perforation.
Croatian: Postoje izvještaji o ulkusima zakompliciranim s perforacijom probavnog sustava.
English: In patients whose serum ferritin level has reached the target (usually between 500 and 1,000 µg/l), dose reductions in steps of 3.5 to 7 mg/kg should be considered to maintain serum ferritin levels within the target range and to minimise the risk of overchelation.
Croatian: U bolesnika u kojih je razina feritina u serumu dostigla cilj (obično između 500 i 1000 µg/l) treba se razmotriti snižavanje doze u koracima od 3,5 do 7 mg/kg kako bi se održale razine feritina u serumu unutar ciljnog raspona te kako bi se rizik od prekomjerne kelacije sveo na najmanju moguću mjeru.
English: Deferasirox Mylan can be used by people aged 65 years and over at the same dose as for other adults.
Croatian: Osobe u dobi od 65 godina i više mogu uzimati Deferasiroks Mylan u istim dozama kao i druge odrasle osobe.
English: Deferasirox Mylan contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free'.
Croatian: Deferasiroks Mylan sadrži manje od 1 mmol (23 mg) natrija po tableti, tj. zanemarive količine natrija.
English: In two clinical studies, growth and sexual development of paediatric patients treated with deferasirox for up to 5 years were not affected (see section 4.4).
Croatian: U dva klinička ispitivanja rast i spolni razvoj pedijatrijskih bolesnika liječenih deferasiroksom u trajanju do 5 godina nije bio oštećen (vidjeti dio 4.4).
English: The majority of these patients had renal impairment, renal tubulopathy (Fanconi syndrome) or diarrhoea, or conditions where acid-base imbalance is a known complication (see section 4.4).
Croatian: Većina tih bolesnika imala je oštećenje bubrega, bubrežnu tubulopatiju (Fanconijev sindrom) ili proljev, ili stanja kod kojih je acido-bazna neravnoteža poznata komplikacija (vidjeti dio 4.4).
English: ◦ The need to interrupt treatment after a dose reduction if serum creatinine rises: Adults and Paediatrics: remain >33% above baseline or creatinine clearance <LLN (90 ml/min)
Croatian: ◦ potreba da se prekine liječenje nakon smanjenja doze u slučaju porasta serumskog kreatinina: odrasli i pedijatrijski bolesnici: ostaje > 33% iznad početne vrijednosti ili klirens kreatinina < DGN (90 ml/min)
English: What Deferasirox Mylan is and what it is used for
Croatian: Što je Deferasiroks Mylan i za što se koristi
English: Deferasirox Mylan is not recommended in patients with severe hepatic impairment (Child-Pugh Class C).
Croatian: Deferasiroks Mylan se ne preporučuje u bolesnika s teškim oštećenjem jetre (Child Pugh stadij C).
English: Clinical efficacy studies were conducted with deferasirox dispersible tablets.
Croatian: Ispitivanja kliničke djelotvornosti provedena su s deferasiroks tabletama za oralnu suspenziju.
English: No clinical data on exposed pregnancies are available for deferasirox.
Croatian: Ne postoje klinički podaci o izloženosti deferasiroksu u trudnoći.
English: • A decrease in the number of cells involved in blood clotting (thrombocytopenia), in the number of red blood cells (anaemia aggravated), in the number of white blood cells (neutropenia) or in the number of all kinds of blood cells (pancytopenia)
Croatian: - Smanjenje broja stanica koje su uključene u zgrušavanje krvi (trombocitopenija), broja crvenih krvnih stanica (pogoršanje anemije), broja bijelih krvnih stanica (neutropenija) ili svih vrsta krvnih stanica (pancitopenija) - Gubitak kose - Bubrežni kamenci - Slabo mokrenje
English: Hepatic failure Skin and subcutaneous tissue disorders Common:
Croatian: Poremećaji kože i potkožnog tkiva Često:
English: The availability of long-term efficacy and safety data from clinical studies conducted with deferasirox dispersible tablets used at doses above 30 mg/kg is currently limited (264 patients followed for an average of 1 year after dose escalation).
Croatian: Trenutačno se raspolaže tek ograničenim podacima iz provedenih kliničkih ispitivanja o dugotrajnoj djelotvornosti i sigurnosti deferasiroks tableta za oralnu suspenziju pri dozama iznad 30 mg/kg (264 bolesnika koji su bili praćeni prosječno 1 godinu nakon povećavanja doze).
English: CYP450-catalysed (oxidative) metabolism of deferasirox appears to be minor in humans (about 8%).
Croatian: Izgleda da je u ljudi metabolizam deferasiroksa (oksidativni) kataliziran s CYP450 vrlo slabo zastupljen (oko 8%).
English: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), which could be life- threatening or fatal, have been reported.
Croatian: Prijavljene su teške kožne nuspojave uključujući Stevens-Johnsonov sindrom (SJS), toksičnu epidermalnu nekrolizu (TEN) i reakciju na lijek s eozinofilijom i sistemskim simptomima (engl. drug reaction with eosinophilia and systemic symptoms, DRESS), koje mogu biti opasne po život ili smrtonosne.
English: Deferasirox Mylan film-coated tablets may be taken either on an empty stomach or with a light meal, preferably at the same time each day (see sections 4.2 and 5.2).
Croatian: Deferasiroks Mylan filmom obložene tablete mogu se uzimati ili na prazan želudac ili uz lagani obrok, po mogućnosti svakoga dana u isto vrijeme (vidjeti dijelove 4.2 i
English: Pyrexia, oedema, fatigue
Croatian: pireksija, edem, umor
English: Vision and hearing
Croatian: Ispitivanje sluha i vida
English: How much Deferasirox Mylan to take The dose of Deferasirox Mylan is related to body weight for all patients.
Croatian: Koliko lijeka Deferasiroks Mylan uzeti Doza lijeka Deferasiroks Mylan u svakog bolesnika ovisi o njegovoj tjelesnoj težini.
English: ◦ The need to reduce by 10 mg/kg the dose if serum creatinine rises: Adults: >33% above baseline and creatinine clearance <LLN (90 ml/min) Paediatrics: either >ULN or creatinine clearance falls to <LLN at two consecutive visits.
Croatian: ◦ potreba smanjenja doze za 10 mg/kg ako dođe do rasta serumskog kreatinina: odrasli bolesnici: > 33% iznad početne vrijednosti i klirens kreatinina < DGN (90 ml/min) pedijatrijski bolesnici: bilo > GGN ili kad klirens kreatinina padne na < DGN u dva uzastopna posjeta.
English: • 14 mg per kilogram body weight for adult patients not receiving regular blood transfusions,
Croatian: • 14 mg po kilogramu tjelesne težine za odrasle bolesnike koji ne primaju redovite transfuzije krvi,
English: It appeared from preclinical and clinical studies that deferasirox dispersible tablets could be as active as deferoxamine when used in a dose ratio of 2:1 (i.e. a dose of deferasirox dispersible tablets that is numerically half of the deferoxamine dose).
Croatian: Pretklinička i klinička ispitivanja pokazala su, čini se, da bi deferasiroks tablete za oralnu suspenziju mogle biti jednako aktivne kao i deferoksamin ako bi se primjenjivale u omjeru doza 2:1 (tj. doza deferasiroks tableta za oralnu suspenziju trebala bi iznositi polovicu brojčane vrijednosti doze deferoksamina).
English: However, in patients with liver iron concentration <7 mg Fe/g dw treated with deferasirox dispersible tablets (5 and 10 mg/kg) or deferoxamine (20 to 35 mg/kg), non-inferiority was not established due to imbalance in the dosing of the two chelators.
Croatian: Međutim, u bolesnika s koncentracijom željeza u jetri < 7 mg Fe/g suhe težine liječenih deferasiroks tabletama za oralnu suspenziju (5 i 10 mg/kg) ili deferoksaminom (20 do 35 mg/kg) neinferiornost nije potvrđena zbog neravnoteže u doziranju dvaju kelatora.
English: For patients who are unable to swallow whole tablets, Deferasirox Mylan film-coated tablets may be crushed and taken by sprinkling the full dose onto soft food such as yogurt or apple sauce (pureed apple).
Croatian: Za bolesnike koji ne mogu progutati cijele tablete, Deferasiroks Mylan filmom obložene tablete mogu se zdrobiti i uzeti posipanjem cijele doze na meku hranu kao što je jogurt ili jabučna kaša (pire od jabuke).
English: An interaction between deferasirox and other CYP2C8 substrates like paclitaxel cannot be excluded.
Croatian: Ne može se isključiti interakcija između deferasiroksa i drugih supstrata CYP2C8 kao što je paklitaksel.
English: Clinical study in patients with non-transfusion-dependent thalassaemia syndromes
Croatian: Kliničko ispitivanje u bolesnika sa sindromima talasemije neovisnim o transfuziji
English: Deferasirox metabolism depends on UGT enzymes.
Croatian: Metabolizam deferasiroksa ovisi o UGT-enzimima.
English: Serum creatinine at Day - X
Croatian: Prije početka liječenja Serumski kreatinin na dan - X
English: In patients in whom LIC was not assessed and serum ferritin is ≤2,000 µg/l, dosing should not exceed 7 mg/kg.
Croatian: U bolesnika u kojih LIC nije utvrđen i serumski feritin je ≤ 2000 µg/l, doziranje ne smije prelaziti 7 mg/kg.
English: Serum ferritin
Croatian: Serumski feritin
English: Maximum dose 14 mg/kg/day 7 mg/kg/day
Croatian: Maksimalna doza 14 mg/kg/dan 7 mg/kg/dan
English: For patients in whom the dose was increased to >7 mg/kg, dose reduction to 7 mg/kg or less is recommended when LIC is <7 mg Fe/g dw or serum ferritin is ≤2,000 µg/l.
Croatian: U bolesnika u kojih je doza povećana na > 7 mg/kg, preporučuje se smanjenje doze na 7 mg/kg ili manje kad je LIC < 7 mg Fe/g težine suhog tkiva jetre ili je serumski feritin ≤ 2000 µg/l.
English: Other medicines and Deferasirox Mylan
Croatian: Drugi lijekovi i Deferasiroks Mylan
English: Diarrhoea is reported more commonly in paediatric patients aged 2 to 5 years and in the elderly.
Croatian: Proljev je češće prijavljen u pedijatrijskih bolesnika u dobi od 2 do 5 godina i u starijih bolesnika.