FrancophonIA/ELRC3.0 huggingface dataset:
English: Never change your dose yourself, unless a doctor has told you to.
Slovenian: Odmerka si nikdar ne znižajte sami, če vam tako ne naroči zdravnik.
English: Neoplasms benign, malignant and unspecified (including cysts and polyps) Patients receiving immunosuppressive therapies, including ciclosporin and ciclosporin containing regimens, are at increased risk of developing lymphomas or lymphoproliferative disorders and other malignancies, particularly of the skin.
Slovenian: Benigne, maligne in neopredeljene novotvorbe (vključno s cistami in polipi) Pri bolnikih, ki prejemajo imunosupresivno zdravljenje, vključno s ciklosporinom in shemami zdravljenja, ki vsebujejo ciklosporin, obstaja povečano tveganje za razvoj limfoma ali drugih limfoproliferativnih bolezni in drugih malignih bolezni, posebno malignih bolezni kože.
English: Forced emesis and gastric lavage may be of value within the first few hours after oral intake.
Slovenian: Izzivanje bruhanja in izpiranje želodca sta lahko koristna v prvih nekaj urah po zaužitju.
English: Before and during treatment with Sandimmun, tell your doctor straight away:
Slovenian: Pred in med zdravljenjem z zdravilom Sandimmun morate takoj obvestiti zdravnika:
English: In patients with nephrotic syndrome treated with immunosuppressants (including ciclosporin), the occurrence of malignancies (including Hodgkin's lymphoma) has occasionally been reported.
Slovenian: Pri bolnikih z nefrotskim sindromom, zdravljenih z imunosupresivi (vključno s ciklosporinom), so občasno poročali o razvoju malignih bolezni (vključno s Hodgkinovim limfomom).
English: • Nerve problems with numbness or tingling in fingers and toes.
Slovenian: • prizadetost živcev z odrevenelostjo ali mravljinčenjem v prstih rok in nog
English: In the 78-week mouse study, at doses of 1, 4, and 16 mg/kg/day, evidence of a statistically significant trend was found for lymphocytic lymphomas in females, and the incidence of hepatocellular carcinomas in mid-dose males significantly exceeded the control value.
Slovenian: V raziskavi na miših, ki je trajala 78 tednov in pri kateri so živalim dajali 1, 4 in 16 mg/kg/dan, so ugotovili statistično značilen trend pojavljanja limfocitnega limfoma pri samicah in statistično značilno večjo pogostost pojavljanja hepatocelularnega karcinoma pri samcih, ki so dobivali srednje visoke odmerke, kot v kontrolni skupini.
English: Prophylactic administration of an antihistamine (H1 + H2 blocker) prior to Sandimmun concentrate for solution for infusion has also been successfully employed to prevent the occurrence of anaphylactoid reactions.
Slovenian: Tudi s profilaktično uporabo antihistaminikov (antagonistov receptorjev H1 in H2) pred odmerjanjem zdravila Sandimmun koncentrat za raztopino za infundiranje so uspešno preprečevali pojavljanje anafilaktoidnih reakcij.
English: Since Sandimmun has been reported to induce a reversible slight increase in blood lipids, it is advisable to perform lipid determinations before treatment and after the first month of therapy.
Slovenian: Poročali so, da zdravilo Sandimmun povzroča manjše reverzibilno zvišanje koncentracije lipidov v krvi, zato je priporočljivo določanje koncentracije lipidov pred zdravljenjem in en mesec po začetku zdravljenja.
English: Ciclosporin may reduce the clearance of digoxin, colchicine, HMG-CoA reductase inhibitors (statins) and etoposide.
Slovenian: Ciklosporin lahko zmanjša očistek digoksina, kolchicina, zaviralcev reduktaze HMG-CoA (statinov)
English: Sandimmun 50 mg/ml concentrate for solution for infusion contains around 34% v/v ethanol (27.8% m/v ethanol).
Slovenian: Sandimmun 50 mg/ml koncentrat za raztopino za infundiranje vsebuje približno 34 % volumskega deleža etanola (kar je 27,8 % masnega deleža).
English: For maintenance treatment, doses have to be titrated individually to the lowest effective level, and should not exceed 5 mg/kg/day.
Slovenian: Za vzdrževalno zdravljenje je treba odmerek pri vsakem posameznem bolniku titrirati do najnižje še učinkovite ravni, pri čemer ne sme presegati 5 mg/kg/dan.
English: Your doctor will carry out regular blood tests and may change your dose if necessary.
Slovenian: Zdravnik bo redno izvajal krvne preiskave in vam po potrebi prilagodil odmerek zdravila.
English: The determination of bilirubin and parameters that assess hepatic function are required prior to starting therapy and close monitoring during treatment is recommended.
Slovenian: Pred začetkom zdravljenja je treba določiti vrednost bilirubina in parametrov za oceno jetrne funkcije, med zdravljenjem pa je priporočeno skrbno spremljanje navedenih parametrov.
English: • Serious liver problems both with and without yellowing of the eyes or skin, nausea (feeling sick), loss of appetite, dark coloured urine, swelling of the face, feet, hands and/or the whole body.
Slovenian: • resne težave z jetri z in brez porumenevanja oči ali kože, z navzeo (občutkom slabosti), z izgubo apetita, s temno obarvanim urinom in z otekanjem v obraz, stopala, roke in/ali celo telo
English: Rifampicin induces ciclosporin intestinal and liver metabolism.
Slovenian: Rifampicin inducira presnovo ciklosporina v črevesju in jetrih.
English: Co-administration of ciclosporin with bosentan is not recommended (see above subsection “Drugs that decrease ciclosporin levels” and section 4.3).
Slovenian: Sočasna uporaba ciklosporina in bosentana ni priporočena (glejte zgoraj podpoglavje "Zdravila, ki znižujejo koncentracijo ciklosporina" in poglavje 4.3).
English: It prevents rejection of transplanted organs by blocking the development of certain cells which would normally attack the transplanted tissue.
Slovenian: Zdravilo preprečuje zavrnitev presajenega organa tako, da zavira razvoj določenih celic, ki bi sicer napadle presajeno tkivo.
English: It is a potent immunosuppressive agent, which in animals prolongs survival of allogeneic transplants of skin, heart, kidney, pancreas, bone marrow, small intestine or lung.
Slovenian: To je močno imunosupresivno sredstvo, za katerega so v raziskavah na živalih dokazali, da podaljša preživetje alogenih presadkov kože, srca, ledvic, trebušne slinavke, kostnega mozga, tankega črevesa in pljuč.
English: In 15 renal transplant patients aged 3 -16 years, ciclosporin whole blood clearance after intravenous administration of Sandimmun was 10.6±3.7 ml/min/kg (assay: Cyclo-trac specific RIA).
Slovenian: Pri 15 bolnikih s presajeno ledvico, starih 3-16 let, je po intravenskem odmerjanju zdravila Sandimmun znašal očistek ciklosporina iz krvi 10,6±3,7 ml/min/kg (analizna metoda: Cyclo-trac specifičen radioimunski test).
English: Ciclosporin enhances the risk of hyperkalaemia, especially in patients with renal dysfunction.
Slovenian: Ciklosporin povečuje tveganje za nastanek hiperkaliemije, zlasti pri bolnikih z okvarjenim delovanjem ledvic.
English: Pregnancy Animal studies have shown reproductive toxicity in rats and rabbits.
Slovenian: Študije na živalih so pokazale vpliv na sposobnost razmnoževanja pri podganah in kuncih.
English: Polyethoxylated castor oil: 650 mg/ml.
Slovenian: Makrogolglicerol ricinolat: 650 mg/ml.
English: Combination with products containing Hypericum perforatum (St John´s Wort) (see section 4.5).
Slovenian: Kombinacija s pripravki, ki vsebujejo Hypericum perforatum (šentjanževko) (glejte poglavje 4.5).
English: If you take more Sandimmun than you should
Slovenian: Če ste prejeli večji odmerek zdravila Sandimmun, kot bi smeli
English: Solid organ transplantation
Slovenian: Presaditev čvrstih organov
English: This may be harmful in alcoholic patients and should be taken into account in pregnant or breast-feeding women, in patients presenting with liver disease or epilepsy, or if the patients is a child.
Slovenian: ki so odvisni od alkohola, pozornost pa je potrebna tudi pri nosečnicah in doječih materah, bolnikih z boleznijo jeter ali epilepsijo in v primeru, da je bolnik še otrok.
English: Oral doses of ciclosporin of up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia and in a few patients moderately severe, reversible impairment of renal function.
Slovenian: (približno 150 mg/kg) so ljudje prenašali s sorazmerno malo pomembnimi kliničnimi posledicami, kot so bruhanje, zaspanost, glavobol, tahikardija in pri nekaj bolnikih zmerno huda, reverzibilna okvara delovanja ledvic.
English: To do this, your doctor may need to do some blood tests.
Slovenian: V ta namen pa morate opraviti nekaj krvnih preiskav.
English: It is a clear, yellow to yellow-brownish liquid with a small amount of very fine sediment.
Slovenian: Bistra rumena do rjavo rumena tekočina z manjšo količino zelo fine usedline.
English: 4.1 Therapeutic indications
Slovenian: 4.1 Terapevtske indikacije Indikacije pri presaditvah
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Slovenian: Če imate dodatna vprašanja o uporabi zdravila, se posvetujte s svojim zdravnikom ali farmacevtom.
English: The concentrate for solution for infusion contains 50 mg/ml.
Slovenian: Koncentrat za raztopino za infundiranje vsebuje 50 mg/ml.
English: Treatment with Sandimmun should be initiated within 12 hours before surgery at a dose of 10 to 15 mg/kg given in 2 divided doses.
Slovenian: Zdravljenje z zdravilom Sandimmun je treba začeti v roku 12 ur pred kirurškim posegom, in sicer v odmerku 10 do 15 mg/kg v dveh deljenih odmerkih.
English: Lymphadenopathy which persists despite improvement in disease activity should be examined by biopsy as a precautionary measure to ensure the absence of lymphoma.
Slovenian: Če limfadenopatija vztraja kljub izboljšanju simptomov bolezni, je zaradi previdnosti potrebna biopsija za potrditev, da ne gre za limfom.
English: • Excessive hair growth.
Slovenian: • prekomerna poraščenost
English: Do not take Sandimmun:
Slovenian: Ne jemljite zdravila Sandimmun:
English: If Sandimmun is used to initiate therapy, the recommended daily dose is 12.5 to 15 mg/kg given in 2 divided doses, starting on the day before transplantation.
Slovenian: Če bolnik za začetno zdravljenje prejema zdravilo Sandimmun, je priporočeni dnevni odmerek 12,5 do 15 mg/kg v dveh deljenih odmerkih, jemati pa naj ga začne en dan pred presaditvijo.
English: If you get high blood pressure during treatment and it cannot be controlled, Sandimmun should be stopped by your doctor.
Slovenian: Če med zdravljenjem pride do visokega krvnega tlaka, ki se ga ne da urediti, vam mora zdravnik ukiniti zdravljenje z zdravilom Sandimmun.
English: Sandimmun oral solution and soft gelatin capsules are bioequivalent.
Slovenian: Sandimmun peroralna raztopina in mehke želatinske kapsule so med seboj biološko enakovredne.
English: Administration of ciclosporin 3 hours after lercanidipine yielded no change of the lercanidipine AUC, but the ciclosporin AUC was increased by 27%.
Slovenian: Pri odmerjanju ciklosporina 3 ure po odmerjanju lerkadipina se AUC lerkadipina ni spremenila, AUC ciklosporina pa se je povečala za 27 %.
English: The 4-ml syringe is used to measure doses greater than 1 ml and up to 4 ml (each graduation of 0.1 ml corresponds to 10 mg of ciclosporin).
Slovenian: 4-mililitrska brizga je primerna za pripravljanje odmerkov od 1 ml naprej do največ 4 ml (vsaka oznaka za 0,1 ml ustreza 10 mg ciklosporina).
English: The hepatocellular carcinomas and pancreatic islet cell adenomas were not dose related.
Slovenian: Hepatocelularni karcinom in adenom pankreasnih otočkov pri poskusnih živalih nista bila odvisna od višine odmerka.
English: Renal toxicity should be monitored when initiating ciclosporin use together with active substances that increase ciclosporin levels or with substances that exhibit nephrotoxic synergy (see section 4.5).
Slovenian: Toksično delovanje na ledvice je treba spremljati na začetku uporabe ciklosporina skupaj z učinkovinami, ki zvišujejo koncentracijo ciklosporina, ali s snovmi s sinergističnim toksičnim delovanjem na ledvice (glejte poglavje 4.5).
English: If you forget to take Sandimmun
Slovenian: Če ste pozabili vzeti zdravilo Sandimmun
English: Azitromycin increases ciclosporin levels by around 20%.
Slovenian: Azitromicin zviša koncentracijo ciklosporina za približno 20 %.
English: If NSAIDs with a low first-pass effect (e.g. acetylsalicylic acid) are given together with ciclosporin, no increase in their bioavailability is to be expected.
Slovenian: Pri sočasnem jemanju ciklosporina in nesteroidnih protivnetnih zdravil z majhnim obsegom metabolizma prvega prehoda (na primer acetilsalicilne kisline) ne gre pričakovati povečanja njihove biološke uporabnosti.
English: Do not stop taking Sandimmun unless your doctor tells you to.
Slovenian: Ne prenehajte jemati zdravila Sandimmun, razen če vam tako naroči zdravnik.
English: Sandimmun contains ethanol
Slovenian: Zdravilo Sandimmun vsebuje etanol
English: Most reports included patients with significant co-morbidities, underlying conditions and other confounding factors including infectious complications and co-medications with hepatotoxic potential.
Slovenian: Večina poročil je vključevala bolnike s pomembnimi sočasnimi boleznimi, osnovnimi boleznimi in drugimi begajočimi dejavniki, vključno z zapleti zaradi okužbe in s sočasnim jemanjem zdravil z možnostjo toksičnega delovanja na jetra.
English: Sandimmun 25 mg soft capsules Sandimmun 50 mg soft capsules Sandimmun 100 mg soft capsules ciclosporin
Slovenian: Sandimmun 25 mg mehke kapsule Sandimmun 50 mg mehke kapsule Sandimmun 100 mg mehke kapsule ciklosporin
English: • If you have had an organ transplant, bone marrow and stem cell transplantation, the function of Sandimmun is to control your body's immune system.
Slovenian: • Če ste prejemnik presajenega organa, kostnega mozga ali presajenih matičnih celic, je naloga zdravila Sandimmun, da zavira imunski sistem vašega organizma.
English: Treatment of transplant cellular rejection in patients previously receiving other immunosuppressive agents.
Slovenian: Zdravljenje celičnega zavračanja presadka pri bolnikih, ki so prej že dobivali druga imunosupresivnazdravila.
English: Special caution is therefore necessary in patients who have previously received preparations containing polyethoxylated castor oil (e.g. a preparation containing Cremophor® EL) by intravenous injection or infusion, and in patients with an allergic predisposition.
Slovenian: Zato je potrebna posebna pozornost pri bolnikih, ki so že prej prejeli intravensko injekcijo ali infuzijo sredstva, ki vsebuje makrogolglicerol ricinolat (na primer sredstvo, ki vsebuje Cremophor® EL), in pri bolnikih, ki so nagnjeni k alergijskim reakcijam.
English: What Sandimmun looks like and contents of the pack Sandimmun 25 mg soft capsules are pink and oval.
Slovenian: Izgled zdravila Sandimmun in vsebina pakiranja Sandimmun 25 mg mehke kapsule so rožnate barve in ovalne oblike.
English: Within each frequency grouping, adverse drug reactions are presented in order of decreasing seriousness.
Slovenian: V okviru posamezne kategorije pogostnosti so neželeni učinki navedeni po padajoči resnosti.
English: The 1-ml syringe is used to measure doses less than or equal to 1 ml (each graduation of 0.05 ml corresponds to 5 mg of ciclosporin).
Slovenian: 1-mililitrska brizga je primerna za pripravljanje odmerkov z volumnom 1 ml ali manj (vsaka oznaka za 0,05 ml ustreza 5 mg ciklosporina).
English: Treatment of Behçet uveitis with repeated inflammatory attacks involving the retina in patients without neurological manifestations.
Slovenian: Zdravljenje Behcetovega uveitisa z rekurentnimi vnetji, ki zajemajo mrežnico, pri bolnikih brez nevroloških obolenj.
English: Effective pre-emptive and therapeutic strategies should be employed, particularly in patients on multiple long-term immunosuppressive therapy.
Slovenian: Poskrbeti je treba za preventivne in terapevtske ukrepe, še posebno pri bolnikih, ki dolgotrajno prejemajo imunosupresivno zdravljenje z več imunosupresivi.
English: Prevention of graft rejection following solid organ transplantation.
Slovenian: Presaditev čvrstih organov Preprečevanje zavračanja presadka po presaditvi čvrstega organa.
English: Swallow the capsules whole with water.
Slovenian: Kapsule vzemite iz pretisnega omota in jih pogoltnite cele z nekaj vode.
English: Special excipients: Ethanol
Slovenian: Posebne pomožne snovi: etanol
English: During the concomitant use of a drug that may exhibit nephrotoxic synergy, close monitoring of renal function should be performed.
Slovenian: Med sočasno uporabo zdravila s sinergističnim toksičnim delovanjem na ledvice je potrebno skrbno spremljanje ledvične funkcije.
English: Following concomitant administration of ciclosporin and lercanidipine, the AUC of lercanidipine was increased three-fold and the AUC of ciclosporin was increased 21%.
Slovenian: Pri sočasni uporabi ciklosporina in lerkanidipina se je AUC lerkanidipina trikrat povečala, AUC ciklosporina pa se je povečala za 21 %.
English: The excretion is primarily biliary, with only 6% of an oral dose excreted in the urine, and with less than 1% in the unchanged form (see sections 4.2 and 4.4).
Slovenian: Samo 6 % peroralnega odmerka se izloči z urinom in manj kot 1 % v obliki nespremenjenega zdravila (glejte poglavji 4.2 in 4.4).
English: Drugs that increase ciclosporin levels
Slovenian: Zdravila, ki zvišujejo koncentracijo ciklosporina
English: If you stop taking Sandimmun
Slovenian: Če ste prenehali jemati zdravilo Sandimmun
English: With the exception of patients being treated for nephrotic syndrome, patients with impaired renal function should not receive ciclosporin (see subsection on additional precautions in nontransplantation indications in section 4.4).
Slovenian: Bolniki z okvaro ledvic, z izjemo bolnikov z nefrotskim sindromom, ne smejo prejemati ciklosporina (glejte poglavje 4.4 pod naslovom Dodatna opozorila pri indikacijah, ki niso povezane s presaditvijo).
English: Additional precautions in rheumatoid arthritis
Slovenian: Dodatna opozorila pri revmatoidnem artritisu
English: Ciclosporin is extensively metabolised to approximately 15 metabolites.
Slovenian: Ciklosporin se v veliki meri presnavlja v približno 15 presnovkov.
English: The concomitant intake of grapefruit and grapefruit juice has been reported to increase the bioavailability of ciclosporin.
Slovenian: Poročali so, da sočasno uživanje grenivke oziroma grenivkinega soka poveča biološko uporabnost ciklosporina.
English: In psoriatic patients on ciclosporin, as in those on conventional immunosuppressive therapy, development of malignancies (in particular of the skin) has been reported.
Slovenian: Pri bolnikih s psoriazo, tako pri tistih, ki uporabljajo ciklosporin, kot pri tistih z običajnim imunosupresivnim zdravljenjem, so poročali o razvoju malignih bolezni (predvsem malignih bolezni kože).
English: Rheumatoid arthritis Treatment of severe, active rheumatoid arthritis.
Slovenian: Zdravljenje hudega aktivnega revmatoidnega artritisa.
English: In refractory cases, the dose can be increased to 7 mg/kg/day for a limited period.
Slovenian: rezistentnih primerih je mogoče odmerek začasno zvišati na 7 mg/kg/dan.
English: • The 4 ml syringe is used to measure doses bigger than 1 ml and up to 4 ml.
Slovenian: • 4-mililitrska brizga je namenjena odmerjanju volumnov, ki so večji od 1 ml in segajo do 4 ml.
English: For monitoring ciclosporin levels in whole blood, a specific monoclonal antibody (measurement of parent compound) is preferred; a high-performance liquid chromatography (HPLC) method, which also measures the parent compound, can be used as well.
Slovenian: Koncentracijo ciklosporina v polni krvi je najbolje določati s pomočjo specifičnih monoklonskih protiteles (meritev koncentracije matične učinkovine); primerna je tudi tekočinska kromatografija visoke ločljivosti ( angl. high-performance liquid chromatography - HPLC), s katero je prav tako mogoče meriti koncentracijo matične učinkovine.
English: • Acne, hot flushes.
Slovenian: • akne, vročinski oblivi
English: Since Sandimmun can impair renal function, it is necessary to assess renal function frequently.
Slovenian: Zdravilo Sandimmun lahko okvari delovanje ledvic, zato je treba pogosto spremljati ledvično funkcijo.
English: Drugs that decrease ciclosporin levels
Slovenian: Zdravila, ki znižujejo koncentracijo ciklosporina
English: Steroid-dependent and steroid-resistant nephrotic syndrome, due to primary glomerular diseases such as minimal change nephropathy, focal and segmental glomerulosclerosis, or membranous glomerulonephritis.
Slovenian: Od steroidov odvisen oziroma na steroidno zdravljenje rezistenten nefrotski sindrom, ki je posledica katere od primarnih glomerulnih bolezni, kot so nefropatija z minimalnimi spremembami, fokalna in segmentna glomeruloskleroza ali membranski glomerulonefritis.
English: Sandimmun contains around 12% vol. ethanol.
Slovenian: Zdravilo Sandimmun vsebuje 12 vol. % etanola.
English: Posology The dose ranges given for oral administration are intended to serve as guidelines only.
Slovenian: Odmerjanje Naslednji okviri odmerjanja naj služijo le kot smernice.
English: Studies suggest that ciclosporin inhibits the development of cell-mediated reactions, including allograft immunity, delayed cutaneous hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, graft-versushost disease (GVHD), and also T-cell dependent antibody production.
Slovenian: Raziskave kažejo, da ciklosporin zavira razvoj reakcij, ki jih posredujejo celice, med drugim imunsko reakcijo alogenega presadka, pozno kožno preobčutljivost, eksperimentalni alergijski encefalomielitis, Freundov adjuvantni artritis, reakcijo presadka proti prejemniku (GVHD) in od T celic odvisno izdelavo protiteles.
English: In comparison to adult transplant populations, the differences in bioavailability between Sandimmun Neoral and Sandimmun in paediatrics are comparable to those observed in adults.
Slovenian: Razlika med biološko uporabnostjo zdravila Sandimmun Neoral in zdravila Sandimmun pri pediatričnih bolnikih je primerljiva s tovrstno razliko v populaciji odraslih bolnikov po presaditvi.
English: The principal adverse reactions observed in clinical trials and associated with the administration of ciclosporin include renal dysfunction, tremor, hirsutism, hypertension, diarrhoea, anorexia, nausea and vomiting.
Slovenian: Med najbolj pomembnimi neželenimi učinki, ki so jih v kliničnih študijah opažali v povezavi z uporabo ciklosporina, so ledvična disfunkcija, tremor, hirzutizem, hipertenzija, diareja, anoreksija, navzea in bruhanje.
English: Owing to its possible interference with the cytochrome P450 enzyme system, grapefruit juice should be avoided for dilution (see section 4.5).
Slovenian: Zaradi možnosti medsebojnega delovanja z encimskim sistemom s citokromom P450 zdravila ni primerno razredčiti z grenivkinim sokom (glejte poglavje 4.5).
English: • if you have an infection which is not under control with medication.
Slovenian: • če imate okužbo, ki jo niste pozdravili z zdravili,
English: Push the medicine out of the syringe into a small glass with some liquid (not grapefruit juice).
Slovenian: Iztisnite zdravilo iz brizge v majhen kozarec z nekaj tekočine
English: Sandimmun can also be combined with low-dose weekly methotrexate in patients who have insufficient response to methotrexate alone, by using 2.5 mg/kg Sandimmun in 2 divided doses per day initially, with the option to increase the dose as tolerability permits.
Slovenian: Pri bolnikih z nezadostnim odzivom na zdravljenje samo z metotreksatom je mogoče zdravilo Sandimmun kombinirati z nizkimi odmerki metotreksata tedensko, in sicer naj taki bolniki v začetku prejemajo 2,5 mg/kg zdravila Sandimmun na dan v dveh deljenih odmerkih, kasneje pa je ta odmerek mogoče zvišati v skladu s prenašanjem zdravila.
English: If considered necessary, magnesium supplementation should be given.
Slovenian: Po presoji je treba magnezij nadomeščati.
English: This depends on your body weight and what you are taking the medicine for.
Slovenian: Višina odmerka je odvisna o vaše telesne mase in od bolezni, zaradi katere jemljete zdravilo.
English: Talk to your doctor before taking Sandimmun:
Slovenian: Posvetujte se z zdravnikom, preden začnete prejemati zdravilo Sandimmun: