FrancophonIA/ELRC3.0 huggingface dataset:
English: In patients with achlorhydria, such as certain AIDS patients and patients on acid secretion suppressors (e.g. H2-antagonists, proton pump inhibitors), it is advised to administer ketoconazole with an acidic beverage e.g. cola beverage, orange juice.
Croatian: U bolesnika s aklorhidrijom, kao što su bolesnici s AIDS-om i bolesnici koji primaju supresore lučenja želučane kiseline (npr. H2-blokatore, inhibitore protonske pumpe), preporučuje se primjena ketokonazola s kiselim pićem, primjerice kolom ili sokom od naranče.
English: Ketoconazole dose should be adjusted accordingly.
Croatian: U skladu s time treba prilagoditi dozu ketokonazola.
English: They will be checked again after that in case your doctor increases your daily ketoconazole dose.
Croatian: Nakon toga liječnik će razine jetrenih enzima ponovno provjeravati ako povisi Vašu dnevnu dozu ketokonazola.
English: Data from 535 patients with Cushing's disease treated with ketoconazole, along with 13 individual case reports are available in the literature.
Croatian: U literaturi se nalaze podaci o 535 bolesnika s Cushingovom bolesti liječenih ketokonazolom, te 13 pojedinačnih prikaza slučajeva.
English: Liver enzyme monitoring should be performed once weekly during the first month of treatment and then monthly for 6 months.
Croatian: Tijekom prvog mjeseca liječenja jetrene enzime treba pratiti jednom tjedno, a potom jednom mjesečno tijekom 6 mjeseci.
English: Pruritus, rash
Croatian: Pruritus, osip
English: What Ketoconazole HRA is and what it is used for 2.
Croatian: Što je Ketoconazole HRA i za što se koristi 2.
English: Medicinal products affecting gastric acidity impair the absorption of ketoconazole (see section 4.4).
Croatian: Lijekovi koji utječu na kiselost želuca smanjuju apsorpciju ketokonazola (vidjeti dio 4.4).
English: Cinacalcet
Croatian: Cinakalcet
English: Exacerbation or development of inflammatory/autoimmune disorders has been described after Cushing's syndrome remission, including after treatment with ketoconazole.
Croatian: Opisani su slučajevi egzacerbacije ili pojave upalnih/autoimunih poremećaja nakon remisije Cushingovog sindroma, pa i nakon liječenja ketokonazolom.
English: The buprenorphine dose should be adjusted.
Croatian: Treba prilagoditi dozu buprenorfina.
English: Dose of edoxaban needs to be reduced when used concomitantly, please consult edoxaban SmPC.
Croatian: Doza edoksabana mora se smanjiti kad se uzima istodobno, pogledajte sažetak opisa svojstava lijeka edoksabana.
English: Not recommended because of reboxetine narrow's therapeutic margin.
Croatian: Ne preporučuje se zbog uske terapijske širine reboksetina.
English: In reproduction studies, ketoconazole impaired fertility in males and females.
Croatian: U ispitivanjima reproduktivne toksičnosti ketokonazol je štetno utjecao na plodnost mužjaka i ženki.
English: There are no or limited amount of data from the use of Ketoconazole HRA in pregnant women.
Croatian: Nema podataka ili su podaci o primjeni ketokonazola u trudnica ograničeni.
English: All patients should be monitored and informed about the signs and symptoms associated with hypocortisolism (e.g. weakness, fatigue, anorexia, nausea, vomiting, weight-loss, hypotension, hyponatraemia, hyperkalaemia and/or hypoglycaemia).
Croatian: Sve bolesnike potrebno je nadzirati i informirati o znakovima i simptomima povezanim s hipokortizolizmom (npr. slabost, umor, anoreksija, mučnina, povraćanje, gubitak tjelesne težine, hipotenzija, hiponatrijemija, hiperkalijemija i/ili hipoglikemija).
English: Contraindicated as it may increase quetiapine-related toxicity (see section 4.3).
Croatian: Kontraindicirana jer može povećati toksičnost povezanu s kvetiapinom (vidjeti dio 4.3).
English: Ketoconazole is also a potent inhibitor of P-gp: inhibition of P-gp by ketoconazole can increase patients' exposure to medicinal products which are P-gp substrates (see section 4.5).
Croatian: Ketokonazol je također snažan inhibitor P-glikoproteina: inhibicija P-glikoproteina koju uzrokuje ketokonazol može povećati izloženost bolesnika lijekovima koji su supstrati P-glikoproteina (vidjeti dio 4.5).
English: Liver function tests abnormal
Croatian: Abnormalni rezultati testova jetrene funkcije
English: - Ketoconazole is a potent inhibitor of CYP3A4 and can inhibit the metabolism of medicinal products metabolised by this enzyme.
Croatian: - Ketokonazol je snažan inhibitor CYP3A4 i može inhibirati metabolizam lijekova koji se metaboliziraju posredstvom tog enzima.
English: Since ketoconazole is excreted in the milk, mothers who are under treatment must not breast-feed whilst being treated with Ketoconazole HRA (see section 4.3).
Croatian: Budući da se ketokonazol izlučuje u majčino mlijeko, majke koje se liječe Ketoconazoleom HRA ne smiju dojiti (vidjeti dio 4.3).
English: Monitoring of liver function
Croatian: Praćenje jetrene funkcije
English: Ketoconazole can be reintroduced thereafter at a lower dose (see section 4.4); - Treatment with ketoconazole can be stopped abruptly without a need for progressive dose decrease where a change in the therapeutic strategy (e.g. surgery) is desired.
Croatian: Ketokonazol se nakon toga može ponovno uvesti pri nižoj dozi (vidjeti dio 4.4); - Ako se želi promijeniti terapijska strategija (npr. operacija), liječenje ketokonazolom može se naglo prekinuti i ne zahtijeva progresivno smanjivanje doze.
English: * Rosuvastatin is not a CYP 3A4 substrate.
Croatian: * Rosuvastatin nije supstrat izoenzima CYP3A4.
English: • Oedema peripheral (dropsy in extremities)
Croatian: • periferni edem (nakupljanje tekućine u ekstremitetima)
English: Ketoconazole is also a potent inhibitor of androgens synthesis, inhibiting the activity of C17-20 lyase in the adrenals and also in Leydig cells.
Croatian: Ketokonazol je također snažan inhibitor sinteze androgena jer inhibira aktivnost C17-20 liaze u nadbubrežnim žlijezdama te u Leydigovim stanicama.
English: Urticaria, alopecia
Croatian: Urtikarija, alopecija
English: Oedema peripheral, malaise, hot flush
Croatian: Periferni edem, malaksalost, navale vrućine
English: Ketoconazole is a potent inhibitor of CYP3A4: inhibition of CYP3A4 by ketoconazole can increase patients' exposure to a number of medicinal products which are metabolised through this enzymatic system (see section
Croatian: Ketokonazol je snažan inhibitor CYP3A4: inhibicija CYP3A4 koju uzrokuje ketokonazol može povećati izloženost bolesnika velikom broju lijekova koji se metaboliziraju pomoću ovog enzimskog sustava (vidjet dio
English: Contraindicated due to the large increase in these medicinal products concentrations (see section 4.3).
Croatian: Kontraindicirana zbog velikog povećanja koncentracija ovih lijekova (vidjeti dio 4.3).
English: Date of first authorisation: 19 November 2014 Date of latest renewal: <DD month YYYY>
Croatian: Datum posljednje obnove odobrenja: <DD. mjesec GGGG.> 10. DATUM REVIZIJE TEKSTA
English: During the treatment: - close clinical follow-up should be undertaken - measurement of liver enzymes (ASAT, ALAT, gamma GT and alkaline phosphatase) and bilirubin, should be performed at frequent intervals:
Croatian: Tijekom liječenja: - bolesnika treba pomno klinički pratiti - redovito treba mjeriti razine jetrenih enzima (AST, ALT, GGT i alkalnu fosfatazu) i bilirubina:
English: Domperidone:
Croatian: Domperidon:
English: Absorption Ketoconazole is a weak dibasic active substance and thus requires acidity for dissolution and absorption.
Croatian: Ketokonazol je slaba dibazična djelatna tvar te joj je za rastvaranje i apsorpciju potrebna kisela okolina.
English: In the case of increase of liver enzymes levels above 3 times the upper limit of normal, Ketoconazole should be stopped immediately and should not be reintroduced because of the risk of serious hepatic toxicity.
Croatian: Ako je povećanje jetrenih enzima veće od trostruke gornje granice normalnih vrijednosti, terapiju ketokonazolom treba odmah prekinuti te se ne smije ponovno uvoditi zbog rizika od ozbiljne hepatičke toksičnosti.
English: ASAT, ALAT, gammaGT, bilirubin and alkaline phosphatase should be monitored at frequent intervals during treatment (see sections 4.2 and 4.4).
Croatian: Tijekom liječenja treba redovito pratiti razine AST-a, ALT-a, GGT-a, bilirubina i alkalne fosfataze (vidjeti dijelove 4.2 i 4.4).
English: As a precautionary measure, in case of a dose increase after the first six months of treatment, monitoring of liver enzymes should be repeated on a weekly basis for one month.
Croatian: U slučaju povećanja doze nakon prvih šest mjeseci liječenja moraju se, kao mjera opreza, u razdoblju od mjesec dana jednom tjedno provjeravati razine jetrenih enzima.
English: Other medicinal products and Ketoconazole HRA
Croatian: Drugi lijekovi i Ketoconazole HRA
English: In the case of an increase in liver enzymes equal to or greater than 3 times the upper limit of normal, ketoconazole should be stopped immediately and should not be reintroduced due to the risk of serious hepatic toxicity.
Croatian: Ako je povećanje jetrenih enzima jednako ili veće od trostruke gornje granice normalnih vrijednosti, terapiju ketokonazolom treba odmah prekinuti te je se ne smije ponovno uvoditi zbog rizika od ozbiljne hepatičke toksičnosti.
English: Contraindicated due to an increased risk of skeletal muscle toxicity, including rhabdomyolysis (see section 4.3).
Croatian: Kontraindicirana zbog povećanog rizika od toksičnosti za skeletne mišiće, uključujući rabdomiolizu (vidjeti dio 4.3).
English: Dexamethasone, fluticasone, methylprednisolone
Croatian: Deksametazon, flutikazon, metilprednizolon
English: Ketoconazole has a moderate influence in the ability to drive and use machines Patients should be warned about the potential for dizziness and somnolence (see section 4.8) and should be advised not to drive or operate machines if any of these symptoms occur.
Croatian: Bolesnike je potrebno upozoriti na potencijalnu omaglicu i somnolenciju (vidjeti dio 4.8) te im savjetovati da u slučaju pojave tih simptoma ne upravljaju vozilima ili strojevima.
English: Expected effect on drug levels
Croatian: Očekivani učinak na razine lijeka Preporuka za istovremenu primjenu
English: Contraindicated due to an increased bleeding risk (see section 4.3).
Croatian: Kontraindicirana zbog povećanog rizika od krvarenja (vidjeti dio 4.3).
English: (CYP3A enzyme inhibition)
Croatian: (inhibicija enzima CYP3A)
English: sunitinib, lapatinib, nilotinib, bortezomib, paclitaxel, vincristine, vinblastine, cabozantinib, dabrafenib,
Croatian: imatiniba, dasatiniba, sunitiniba, lapatiniba, nilotiniba, bortezomiba, paklitaksela, vinkristina, vinblastina,
English: Phosphodiesterase(PD E5) inhibitors Sildenafil
Croatian: Inhibitori fosfodiesteraze (PDE5)
English: Dose adjustment of aliskiren may be required.
Croatian: Može biti potrebna prilagodba doze aliskirena.
English: Not recommended due to the potential for hepatic toxicity (see section 4.3).
Croatian: Ne preporučuje se zbog potencijalne hepatotoksičnosti (vidjeti dio 4.3).
English: Effects of other medicinal products on the metabolism of ketoconazole
Croatian: Učinci drugih lijekova na metabolizam ketokonazola
English: Observed teratogenic effects were mainly skeletal anomalies, including cleft palate, brachydactylia, ectrodactylia and syndactylia.
Croatian: Teratogeni učinci uočeni su u obliku skeletnih anomalija, uključujući rascjep nepca, brahidaktiliju, ektrodaktiliju i sindaktiliju.
English: A review of concomitant medicinal products should be conducted when initiating ketoconazole treatment since ketoconazole is a known strong CYP3A4 inhibitor.
Croatian: Kod uvođenja terapije ketokonazolom potrebno je provjeriti koje lijekove bolesnik istovremeno uzima jer je ketokonazol poznati snažan inhibitor CYP3A4.
English: Contraindicated due to the risk of potentially prolonged or increased sedation and respiratory depression (see section 4.3).
Croatian: Kontraindicirana zbog rizika od potencijalno produljene ili pojačane sedacije i respiratorne depresije (vidjeti dio 4.3).
English: In the case of an increase in liver enzymes of less than 3 times the upper limit of normal, more frequent monitoring of liver function tests should be performed and the daily dose should be decreased by at least 200 mg.
Croatian: U slučaju povećanja razine jetrenih enzima za manje od trostruke gornje granice normalnih vrijednosti, treba češće pratiti funkciju jetre, a dnevnu dozu treba smanjiti za najmanje 200 mg.
English: If clinical symptoms are suggestive of adrenal insufficiency, cortisol levels should be measured and ketoconazole should be temporarily discontinued or the dose reduced and if necessary corticosteroid substitution should be initiated.
Croatian: Ako klinički simptomi ukazuju na adrenalnu insuficijenciju, treba izmjeriti razine kortizola te privremeno prekinuti liječenje ketokonazolom ili sniziti dozu, a po potrebi treba uvesti nadomjesnu kortikosteroidnu terapiju.
English: Not recommended due to the risk of increased exposure to these medicinal products and QT prolongation.
Croatian: Ne preporučuje se zbog rizika od povećane izloženosti tim lijekovima i produljenja QT intervala.
English: Contraindicated due to the increased risk of serious cardiovascular events including QT prolongation and torsade de pointes, or respiratory or CNS depression (see section 4.3).
Croatian: Kontraindicirana zbog povećanog rizika od ozbiljnih kardiovaskularnih događaja uključujući produljenje QT intervala i nastup torsade de pointes, ili respiratorne depresije ili depresije središnjeg živčanog sustava (vidjeti dio 4.3).
English: In the case an increase of liver enzymes is detected which is less than 3 times the upper limit of normal, closer monitoring of liver function should be performed and the daily dose should be decreased by at least 200 mg.
Croatian: Ako se ustanovi povećanje jetrenih enzima koje je manje od trostruke gornje granice normalnih vrijednosti, treba provoditi pomnije praćenje jetrene funkcije, a dnevnu dozu treba smanjiti za najmanje 200 mg.
English: Ketoconazole is mainly metabolised through CYP3A4.
Croatian: Ketokonazol se uglavnom metabolizira posredstvom CYP3A4.
English: • Hot flush
Croatian: • navale vrućine
English: Ketoconazole HRA is a medicine that contains the active substance ketoconazole.
Croatian: Ketoconazole HRA je lijek koji sadrži djelatnu tvar ketokonazol.
English: ergotamine and methylergometrine (methylergonovine) - certain medicines used in cancers: irinotecan, everolimus - sirolimus: used to prevent your body from rejecting a kidney transplant - tolvaptan used for a specific disease called “syndrome of inappropriate antidiuretic hormone secretion” - vardenafil in men older than 75 years - medicine to treat erectile dysfunction in adults men - certain medicines for HIV: saquinavir/ritonavir, saquinavir - certain medicines to treat long-term (chronic) hepatitis C (an infectious disease that affects the liver, caused by the hepatitis C virus): Paritaprevir/Ombitasvir (ritonavir) - methadone: medicine to treat dependence to drugs - In patients with renal disorders:
Croatian: ergotamin i metilergometrin (metilergonovin) - određene lijekove koji se koriste kod raka: irinotekan, everolimus - sirolimus: koristi se za sprječavanje odbacivanja transplantiranog bubrega - tolvaptan koji se koristi za specifičnu bolest pod nazivom „sindrom neodgovarajućeg izlučivanja antidiuretskog hormona” - vardenafil u muškaraca starijih od 75 godina - lijek za liječenje erektilne disfunkcije u odraslih muškaraca - određene lijekove za HIV: sakinavir/ritonavir, sakinavir - određene lijekove za liječenje dugotrajnog (kroničnog) hepatitisa C (zarazna bolest koja zahvaća jetru, a uzrokuje ju virus hepatitisa C): paritaprevir/ombitasvir (ritonavir) - metadon: lijek za liječenje ovisnosti o drogama - U bolesnika s poremećajima rada bubrega:
English: Dose adjustment of nadolol may be required.
Croatian: Može biti potrebna prilagodba doze nadolola.
English: AUC: ↑ 2 fold Cmax: ↑ 2 fold
Croatian: AUC: ↑ 2 puta Cmax: ↑ 2 puta
English: Dose adjustement of buspirone may be required.
Croatian: Može biti potrebna prilagodba doze buspirona.
English: Musculoskeletal and connective tissue disorder
Croatian: Poremećaji mišićnokoštanog sustava i vezivnog tkiva
English: Gastrointestinal Drugs Aprepitant
Croatian: Gastrointestinalni lijekovi
English: Not recommended due to the increased risk of QT prolongation and extrapyramidal symptoms.
Croatian: Ne preporučuje se zbog povećanog rizika od produljenja QT intervala i ekstrapiramidalnih simptoma.
English: Monitor and instruct patients on the signs and symptoms associated with hypocortisolism (e.g. weakness, fatigue, anorexia, nausea, vomiting, hypotension, hyperkalemia, hyponatraemia, hyperkalaemia or hypoglycaemia).
Croatian: Pratite bolesnike i objasnite im znakove i simptome povezane s hipokortizolizmom (npr. slabost, umor, anoreksija, mučnina, povraćanje, hipotenzija, hiperkalijemija, hiponatrijemija ili hipoglikemija).
English: Potential ↑in plasma concentrations of these drugs
Croatian: Potencijalno ↑ plazmatskih koncentracija ovih lijekova
English: You should not take antacids (eg aluminium hydroxide) or other medicines for acid indigestion for at least 2 hours after the intake of Ketoconazole HRA (see section Warning and Precautions).
Croatian: Najmanje 2 sata nakon unosa Ketoconazolea HRA ne smijete uzimati antacide (npr. aluminijev hidroksid) ili druge lijekove za želučane tegobe uzrokovane kiselinom (pogledajte dio Upozorenja i mjere opreza).
English: If you stop taking Ketoconazole HRA
Croatian: Ako prestanete uzimati Ketoconazole HRA
English: Consistent with the pharmacological action of ketaconazole, effects were observed on adrenal and gonads in rats and dogs.
Croatian: U skladu s farmakološkim djelovanjem ketokonazola primijećeno je djelovanje na nadbubrežne i spolne žlijezde štakora i pasa.
English: The SmPC for concomitantly used products must be consulted for the recommendations regarding coadministration with strong CYP3A4 inhibitors.
Croatian: Treba pročitati sažetak opisa svojstava lijeka koji se istovremeno uzima radi preporuka o istovremenoj primjeni sa snažnim inhibitorima CYP3A4.
English: Quetiapine:
Croatian: Kvetiapin:
English: Elevated liver enzymes and histological changes in the liver consisting in dose-related lipofuscin accumulation in hepatocytes were reported in rats and dogs after repeated administration of ketoconazole.
Croatian: Nakon ponovljene primjene ketokonazola u štakora i pasa prijavljene su povišene razine jetrenih enzima i histološke promjene na jetri koje se sastoje od akumulacije lipofuscina u hepatocitima povezane s dozom.
English: Contraindicated due to the increased risk of hyperkalaemia and hypotension (see section 4.3).
Croatian: Kontraindicirana zbog povećanog rizika od hiperkalijemije i hipotenzije (vidjeti dio 4.3).
English: If you forget to take Ketoconazole HRA
Croatian: Ako ste zaboravili uzeti Ketoconazole HRA
English: Dose adjustment of these medicinal products may be required.
Croatian: Može biti potrebna prilagodba doze ovih lijekova.
English: Potential ↑in plasma concentrations of alfentanil and fentanyl
Croatian: Potencijalno ↑ plazmatskih koncentracija alfentanila i fentanila
English: What you need to know before you take Ketoconazole HRA 3.
Croatian: Što morate znati prije nego počnete uzimati Ketoconazole HRA 3. Kako uzimati Ketoconazole HRA 4. Moguće nuspojave
English: AUC: ↑ 3.0 to 3.9-fold
Croatian: Ranolazin: AUC: ↑ 3,0 - 3,9 puta
English: microcrystalline cellulose, silica colloidal, magnesium stearate
Croatian: silicijev dioksid, koloidni, magnezijev stearat
English: Dose adjustment of each medicinal product may be required.
Croatian: Može biti potrebna prilagodba doze pojedinih lijekova.
English: Contraindicated due to an alteration of the metabolism of this medicinal product (see section 4.3).
Croatian: Kontraindicirana zbog izmjene metabolizma ovog lijeka (vidjeti dio
English: A daily dose from 400 mg per day (2 tablets) to 1,200 mg per day (6 tablets) taken orally in 2 to 3 divided doses may be required to restore your normal cortisol levels.
Croatian: Za ponovno uspostavljanje normalnih razina kortizola u Vašem tijelu može biti potrebna dnevna doza od 400 mg na dan (2 tablete) do 1200 mg na dan (6 tableta) koja se uzima kroz usta podijeljena u 2 do 3 doze.
English: Ketoconazole is a potent inhibitor of CYP3A4 and P-gp.
Croatian: Ketokonazol je snažan inhibitor enzima CYP3A4 i P-glikoproteina.
English: Medicinal product by therapeutic area
Croatian: Lijekovi prema terapijskom području
English: AUC: ↑2.1-fold Cmax: ↑1.1-fold t1/2: ↑ 4-fold
Croatian: AUC: ↑ 2,1 puta Cmax: ↑ 1,1 puta t1/2: ↑ 4 puta
English: Nausea, abdominal pain, vomiting, diarrhoea
Croatian: Mučnina, bol u abdomenu, povraćanje,
English: Vincristine, vinblastine (vinca alkaloids)
Croatian: Vinkristin, vinblastin
English: Potential ↑in plasma concentrations of carbamazepine and phenytoin
Croatian: Potencijalno ↑ plazmatskih koncentracija karbamazepina i fenitoina
English: No alcohol should be consumed during treatment with ketoconazole.
Croatian: Ketokonazol i alkohol Tijekom liječenja ketokonazolom ne smije se konzumirati alkohol.
English: Dizziness or somnolence have been reported during treatement with Ketoconazole HRA.
Croatian: Prijavljeni su slučajevi omaglice ili izrazite pospanosti tijekom liječenja Ketoconazoleom HRA.
English: Antidiabetics Repaglinide
Croatian: Antiinfekcijski lijekovi
English: if you get palpitations or an irregular heartbeat during treatment.
Croatian: Ako tijekom liječenja osjetite lupanje srca ili nepravilne otkucaje srca, odmah obavijestite svog liječnika.
English: Contraindicated due to the increased risk of ergotism and other serious vasospastic adverse reactions (see section 4.3).
Croatian: Kontraindicirana zbog povećanog rizika od ergotizma i drugih ozbiljnih vazospastičnih nuspojava (vidjeti dio
English: Contraindicated due to an increase risk of edema and congestive heart failure (see section 4.3).
Croatian: Kontraindicirana zbog povećanog rizika od edema i kongestivnog zatajenja srca (vidjeti dio 4.3).
English: AUC: ↑ 24-fold Cmax: ↑ 29-fold
Croatian: AUC: ↑ 24 puta Cmax: ↑ 29 puta
English: Telithromycin Clarithromycin
Croatian: Klaritromicin
English: Co-administration of ketoconazole and pasireotide is not recommended since the combination can lead to QT prolongation in patients with known cardiac rhythm disorders (see section 4.5).
Croatian: Ne preporučuje se istovremena primjena ketokonazola i pasireotida jer njihova kombinacija u bolesnika s utvrđenim poremećajem srčanog ritma može uzrokovati produljenje QT intervala (vidjeti dio 4.5).
English: (See also “Effects of other medicinal products on the metabolism of Ketoconazole HRA ”)
Croatian: (Vidjeti također „Učinci drugih lijekova na metabolizam Ketoconazolea HRA”)
English: Dose adjustment of saxagliptin may be required.
Croatian: Može biti potrebna prilagodba doze saksagliptina.
English: Ketoconazole HRA 200 mg tablets ketoconazole
Croatian: Ketoconazole HRA 200 mg tablete ketokonazol
English: Ketoconazole is mainly metabolised by cytochrome CYP3A4.
Croatian: Ketokonazol se prvenstveno metabolizira posredstvom citokroma CYP3A4.
English: sertindole, lurasidone, quetiapine - certain medicines used for the allergies: mizolastine - dabigatran - medicine used to prevent the formation of blood clots - certain medicines to help to sleep and for anxiety: triazolam, alprazolam, midazolam (taken by mouth) - certain medicines used for migraine attacks: dihydroergotamine, ergometrine (ergonovine)
Croatian: - određene lijekove protiv alergija: mizolastin - dabigatran - lijek za sprječavanje stvaranja krvnih ugrušaka - određene lijekove za spavanje i anksioznost: triazolam, alprazolam, midazolam (primijenjen kroz usta) - određene lijekove protiv napadaja migrene: dihidroergotamin, ergometrin (ergonovin),
English: Not recommended due to the risk of QT interval prolongation and serious hepatic adverse reactions.
Croatian: Ne preporučuje se zbog rizika od produljenja QT intervala i ozbiljnih nuspojava vezanih uz jetru.
English: (See also “Effects of other medicinal products on the metabolism of ketoconazole HRA ”).
Croatian: (Vidjeti također „Učinci drugih lijekova na metabolizam Ketoconazolea HRA”).
English: • Skin reactions (urticaria)
Croatian: • kožne reakcije (svrbež, osip)