FrancophonIA/ELRC3.0 huggingface dataset:
English: The results of a meta-analysis of 14 clinical trials with data from over 4700 patients treated with capecitabine showed that in all studies combined, female gender was statistically significantly associated with an increased risk of developing HFS and diarrhoea and with a decreased risk of developing neutropenia.
Danish: Resultaterne fra en metaanalyse af 14 kliniske studier med data fra mere end 4.700 patienter, som er blevet behandlet med capecitabin, viste at i alle studier kombineret, var kvindeligt køn statistisk signifikant associeret med en øget risiko for udviklingen af hånd- og fodsyndrom og diarré og med en faldende risiko for at udvikle neutropeni.
English: Coumarin-derivative anticoagulation.
Danish: Antikoagulantia af coumarintypen
English: The results of a meta-analysis of 14 clinical trials with data from over 4700 patients treated with capecitabine showed that in all studies combined, the following covariates were statistically significantly associated with an increased risk of developing diarrhoea: increasing capecitabine starting dose (gram), increasing duration of study treatment (weeks), increasing age (by 10 year increments), and female gender.
Danish: En metaanalyse af 14 kliniske studier med data fra mere end 4.700 patienter, som er blevet behandlet med capecitabin, viste i alle studier kombineret at følgende kovarianter var statistisk signifikant associeret med en øget risiko for udviklingen af diarré: stigende capecitabin-startdosis (gram), længere behandlingsvarighed (uger), stigende alder (ved 10-års forøgelse) samt kvindeligt køn.
English: Hydronephrosis, Urinary incontinence, Haematuria, Nocturia, Blood creatinine increased
Danish: Hydronefrose, Urininkontinens, Hæmaturi, Nokturi, Forøget blodkreatinin
English: When capecitabine was used in combination with other medicinal products, elderly patients (≥65 years) experienced more grade 3 and grade 4 adverse drug reactions, including those leading to discontinuation, compared to younger patients.
Danish: Ældre patienter ((≥ 65 år) havde, sammenlignet med yngre patienter, flere bivirkninger af grad 3 og 4, inklusiv dem, som førte til seponering, når capecitabin blev anvendt i kombination med andre lægemidler.
English: In the allrandomised population, capecitabine was shown to be superior to 5FU/LV for disease-free survival (hazard ratio 0.849; 95% CI 0.739 - 0.976; p = 0.0212), as well as for overall survival (hazard ratio 0.828; 95% CI 0.705 - 0.971; p = 0.0203).
Danish: I den samlede randomiseringspopulation blev capecitabin vist at være bedre end 5-FU/LV mht. sygdomsfri overlevelse (hazard ratio 0,849; 95 % konfidensinterval 0,739 - 0,976; p = 0,0212) og mht. samlet overlevelse (hazard ratio 0,828; 95 % konfidensinterval 0,705 - 0,971; p = 0,0203).
English: Ecansya may make you feel dizzy, nauseous or tired.
Danish: Ecansya forårsage svimmelhed, kvalme og træthed.
English: Ecansya 150 mg film-coated tablets Ecansya 300 mg film-coated tablets Ecansya 500 mg film-coated tablets capecitabine
Danish: Ecansya 150 mg filmovertrukne tabletter Ecansya 300 mg filmovertrukne tabletter Ecansya 500 mg filmovertrukne tabletter capecitabin
English: - in combination with docetaxel (see section 5.1) for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy.
Danish: 5.1) til behandling af patienter med lokal fremskreden eller metastatisk brystkræft efter svigt af cytotoksisk kemoterapi.
English: Capecitabine 1000 mg/m 2 oral twice daily
Danish: 1.000 mg/m2 oral 2 gange daglig
English: Therefore, brivudine must not be administered concomitantly with capecitabine (see section 4.3 and 4.4).
Danish: Brivudin må derfor ikke administreres samtidig med capecitabin (se pkt.
English: Grade 1 hand-foot syndrome is defined as numbness, dysesthesia/paresthesia, tingling, painless swelling or erythema of the hands and/or feet and/or discomfort which does not disrupt the patient's normal activities.
Danish: Grad 1 hånd- og fodsyndrom defineres som følelsesløshed, dysæstesi/paræstesi, prikken, hævelse eller erytem uden smerter af hænderne og/eller fødderne og/eller ubehag der ikke påvirker patienternes daglige aktiviteter.
English: These side effects can become severe; therefore, it is important that you always contact your doctor immediately when you start to experience a side effect.
Danish: Derfor skal du altid kontakte lægen så snart du får en bivirkning.
English: Hand-foot syndrome (see section 4.4): For the capecitabine dose of 1250 mg/m2 twice daily on days 1 to 14 every 3 weeks, a frequency of 53% to 60% of all-grades HFS was observed in capecitabine monotherapy trials (comprising studies in adjuvant therapy in colon cancer, treatment of metastatic colorectal cancer, and treatment of breast cancer) and a frequency of 63% was observed in the capecitabine/docetaxel arm for the treatment of metastatic breast cancer.
Danish: For capecitabindosis på 1.250 mg/m to gange dagligt på dagene 1 til 14 hver 3. uge blev der observeret hånd- og fodsyndrom i alle grader med en hyppighed på 53 % til 60 % i cabecitabinmonoterapistudierne (bestående af studier i adjuverende behandling af kolonkræft, behandling af metastatisk kolorektalkræft og behandling af brystkræft).
English: Monotherapy with capecitabine in metastatic colorectal cancer Data from two identically-designed, multicentre, randomised, controlled phase III clinical trials (SO14695; SO14796) support the use of capecitabine for first line treatment of metastatic colorectal cancer.
Danish: Monoterapi med capecitabin ved metastatisk kolorektalkræft Data fra to identisk designede, randomiserede, kontrollerede, kliniske multicenterstudier i fase III (SO14695; SO14796) støtter anvendelsen af capecitabin til 1. linjebehandling af metastatisk kolorektalkræft.
English: Cytochrome P-450 2C9 substrates: Other than warfarin, no formal interaction studies between capecitabine and other CYP2C9 substrates have been conducted.
Danish: Der er ikke gennemført formelle lægemiddelinteraktionsstudier med capecitabin og andre CYP2C9substrater bortset fra warfarin.
English: Data from one multicentre, randomised, controlled phase 3 clinical trial in patients with stage III (Dukes' C) colon cancer supports the use of capecitabine in combination with oxaliplatin (XELOX) for the adjuvant treatment of patients with colon cancer (NO16968 study).
Danish: Data fra et randomiseret, kontrolleret, klinisk fase III-multicenterstudie hos patienter med kolonkræft i stadium III (Dukes' stadium C) støtter anvendelsen af capecitabin i kombination med oxaliplatin (XELOX) til adjuverende behandling af patienter med kolonkræft (studie NO16968).
English: ADRs are added according to the highest incidence seen in any of the major combination trials.
Danish: Bivirkningerne er anført i frekvensgruppering ud fra den højeste hyppighed set i en af de store kliniske studier.
English: Alopecia, Nail disorder Hyperhidrosis, Rash erythematous, Urticaria, Night sweats
Danish: Hyperhidrose, Erytematøst udslæt, Urticaria, Nattesved
English: Anhydrous lactose Microcrystalline cellulose (E460) Croscarmellose sodium Hypromellose (E-5) Magnesium stearate
Danish: Vandfri lactose Croscarmellosenatrium Hypromellose (E-5) Mikrokrystallinsk cellulose Magnesiumstearat
English: Monotherapy with capecitabine in adjuvant colon cancer Data from one multicentre, randomised, controlled phase III clinical trial in patients with stage III (Dukes' C) colon cancer supports the use of capecitabine for the adjuvant treatment of patients with colon cancer (XACT Study; M66001).
Danish: Adjuverende monoterapi med capecitabin ved kolonkræft Data fra et randomiseret, kontrolleret, klinisk fase III-multicenterstudie hos patienter med kolonkræft i stadium III (Dukes' stadium C) støtter anvendelsen af capecitabin som adjuverende behandling af patienter med kolonkræft (XACT-Studie; M66001).
English: Combination therapy in first-line treatment of metastatic colorectal cancer Data from a multicentre, randomised, controlled phase III clinical study (NO16966) support the use of capecitabine in combination with oxaliplatin or in combination with oxaliplatin and bevacizumab for the first-line treatment of metastatic colorectal cancer.
Danish: Kombinationsterapi i 1. linjebehandling af metastatisk kolorektalkræft Data fra et multicenter, randomiseret, kontrolleret klinisk fase III-studie (NO16966) understøtter anvendelsen af capecitabin i kombination med oxaliplatin eller i kombination med oxaliplatin og bevacizumab til 1. linjebehandling af metastatisk kolorektalkræft.
English: Median progression-free survival (PFS) was 10.0 and 8.9 months; p=0.64, overall survival 25.7 and 27.5 months; p=0.55 and response rates 45.5 and 39.8%; p=0.32 for FOLFIRI-Bev and XELIRI-Bev, respectively.
Danish: For henholdsvis FOLFIRI plus bevacizumab og XELIRI plus bevacizumab var den mediane progressionfri overlevelse 10,0 og 8,9 måneder; p = 0,64, samlet overlevelse var 25,7 og 27,5 måneder; p = 0,55, og responsrater 45,5 % og 39,8 %; = 0,32.
English: Pharyngitis, Oral candidiasis, Influenza, Gastroenteritis, Fungal infection, Infection, Tooth abscess
Danish: Urinvejs-infektion, Cellulitis, Tonsillitis, Faryngitis, Oral candidiasis, Influenza, Gastroenteritis, Svampeinfektion, Infektion, Tandbyld
English: In the all-randomised population, tests for difference of capecitabine vs 5-FU/LV in disease-free and overall survival showed hazard ratios of 0.88 (95% CI 0.77 - 1.01; p = 0.068) and 0.86 (95% CI 0.74 - 1.01; p = 0.060), respectively.
Danish: I testene hos den samlede randomiseringspopulation for forskel mellem capecitabin og 5-FU/LV mht. sygdomsfri og samlet overlevelse var hazard ratios hhv. 0,88 (95 % konfidensinterval 0,77 - 1,01; p = 0,068) og 0,86 (95 % konfidensinterval 0,74 - 1,01; p = 0,060).
English: In these trials, 603 patients were randomised to treatment with capecitabine (1250 mg/m2 twice daily for 2 weeks followed by a 1-week rest period and given as 3-week cycles).
Danish: I studierne blev 603 patienter randomiserede til behandling med capecitabin (1.250 mg/m2 to gange dagligt i 2 uger, efterfulgt af en uges pause, og givet som 3-ugers serier).
English: Lower limb oedema, Hypertension, Embolism and thrombosis
Danish: Ødem i underekstremiteter, Hypertension, Embolisme og tromboser
English: The results of a meta-analysis of 14 clinical trials with data from over 4700 patients treated with capecitabine showed that in all studies combined, increasing age (by 10 year increments) was statistically significantly associated with an increased risk of developing HFS and diarrhoea and with a decreased risk of developing neutropenia.
Danish: Resultaterne fra en metaanalyse af 14 kliniske studier med data fra mere end 4.700 patienter, som er blevet behandlet med capecitabin, viste at i alle studier kombineret, var stigende alder (ved 10-års forøgelse) statistisk signifikant associeret med en øget risiko for udviklingen af hånd- og fodsyndrom og diarré og med en faldende risiko for at udvikle neutropeni.
English: fungal infections (including those of the mouth), influenza, gastroenteritis, tooth abscess - lumps under the skin (lipoma) - decreases in blood cells including platelets, thinning of blood (seen in tests) - allergy - diabetes, decrease in blood potassium, malnutrition, increased blood triglycerides - confusional state, panic attacks, depressed mood, decreased libido - difficulty speaking, impaired memory, loss of movement coordination, balance disorder,
Danish: (også i munden), influenza, maveinfluenza, tandbylder - knuder under huden (lipom) - fald i blodtal, inklusive blodplader, fortyndet blod (kan ses i blodprøve) - allergi - sukkersyge, nedsat indhold af kalium i blodet, underernæring, øget niveau af triglycerider i blodet - forvirring, panikanfald, depression, nedsat sexlyst, - talebesvær, dårlig hukommelse, koordinationsforstyrrelser, balanceforstyrrelser, besvimelse,
English: Manufacturer
Danish: Fremstiller:
English: PVC/PVdC/aluminium blisters Do not store above 30°C.
Danish: PVC/PVdC/aluminium-blistere: Må ikke opbevares ved temperaturer over 30 °C.
English: Table 5 lists ADRs associated with the use of capecitabine in combination with different chemotherapy regimens in multiple indications based on safety data from over 3000 patients.
Danish: Tabel 5 viser de bivirkninger, der er forbundet med anvendelsen af capecitabin administreret i kombination med forskellige kemoterapiregimer indenfor flere indikationer.
English: Hypokalaemia, Hyponatraemia, Hypomagnesaemia,
Danish: Hypokaliæmi, Hyponatriæmi, Hypomagnesiæmi, Hypokalcæmi, Hyperglycæmi
English: Petechiae,
Danish: Erythem,
English: Administration of capecitabine should be interrupted if treatment-related elevations in bilirubin of >3.0 x ULN or treatment-related elevations in hepatic aminotransferases (ALT, AST) of >2.5 x ULN occur.
Danish: Hvis der forekommer behandlingsrelaterede stigninger af bilirubin > 3,0 x UNL eller af hepatiske aminotransferaser (ALAT og ASAT) > 2,5 x UNL skal behandlingen med capecitabin straks afbrydes.
English: Phenytoin: increased phenytoin plasma concentrations resulting in symptoms of phenytoin intoxication in single cases have been reported during concomitant use of capecitabine with phenytoin.
Danish: I enkelte tilfælde er der, under samtidig behandling med capecitabin og phenytoin, rapporteret om stigninger i plasmakoncentrationerne af phenytoin, som har medført symptomer på fenytoinintoksikation.
English: Given as monotherapy, the recommended starting dose for capecitabine in the adjuvant treatment of colon cancer, in the treatment of metastatic colorectal cancer or of locally advanced or metastatic breast cancer is 1250 mg/m2 administered twice daily (morning and evening; equivalent to
Danish: Den anbefalede initialdosis ved capecitabin-monoterapi, til adjuverende behandling af kolonkræft, til behandling af metastatisk kolorektalkræft eller af lokalt fremskreden eller metastatisk brystkræft er 1.250 mg/m2 administreret to gange dagligt (morgen og aften, svarende til en daglig dosis på 2.500 mg/m2) i 14 dage, efterfulgt af 7 dages pause.
English: Ophthalmologic complications: Patients should be carefully monitored for ophthalmological complications such as keratitis and corneal disorders, especially if they have a prior history of eye disorders.
Danish: Patienter bør monitoreres omhyggeligt for oftalmologiske komplikationer såsom keratitis og sygdomme på cornea.
English: In this trial, 1987 patients were randomised to treatment with capecitabine (1250 mg/m2 twice daily for 2 weeks followed by a 1-week rest period and given as 3week cycles for 24 weeks) or 5-FU and leucovorin (Mayo Clinic regimen: 20 mg/m2 leucovorin intravenous followed by 425 mg/m2 intravenous bolus 5-FU, on days 1 to 5, every 28 days for 24 weeks).
Danish: I dette studie blev 1.987 patienter randomiseret til behandling med capecitabin (1.250 mg/m2 to gange dagligt i 2 uger, efterfulgt af en uges pause, givet som 3-ugers serier i 24 uger) eller til behandling med 5-FU og leucovorin (Mayo Clinic-regime: 20 mg/m2 leucovorin intravenøs, efterfulgt af 425 mg/m2 intravenøs 5-FU som bolus på dag 1 til 5, hver 28. dag i 24 uger).
English: In these trials, a total of 236 patients were treated with capecitabine (1250 mg/m2 twice daily for 2 weeks followed by 1-week rest period).
Danish: I disse studier blev 236 patienter behandlet med capecitabin (1.250 mg/m2 to gange dagligt i 2 uger efterfulgt af en uges pause).
English: Non-inferiority of the XELOX-containing arms compared with the FOLFOX-4-containing arms in the overall comparison was demonstrated in terms of progression-free survival in the eligible patient population and the intent-to-treat population (see table 7).
Danish: I den egnede patientpopulation og intent-to-treat-populationen blev der demonstreret non-inferioritet af XELOX-armen, sammenlignet med FOLFOX-4-armen, med hensyn til progressionsfri overlevelse (se tabel 7).
English: Brivudine.
Danish: Brivudin
English: The incidence of grade 3 or 4 adverse reactions in patients with moderate renal impairment (creatinine clearance 30-50 ml/min) is increased compared to the overall population (see sections 4.2 and 4.3).
Danish: Sammenlignet med hele populationen er hyppigheden af bivirkninger af grad 3 eller 4 forøget hos patienter med moderat nyreinsufficiens (creatininclearance 30-50 ml/min) (se pkt.
English: INFORMATION IN BRAILLE Ecansya 300 mg
Danish: INFORMATION I BRAILLE-SKRIFT Ecansya 300 mg
English: How to take Ecansya
Danish: Sådan skal du tage Ecansya
English: Pain in jaw, Muscle spasms, Trismus, Muscular weakness
Danish: Kæbesmerter, Muskelspasmer, Trismus, Muskelsvaghed
English: Tablet coating - Ecansya 150 mg film-coated tablets Hypromellose (6cps)
Danish: Tabletovertrækket - Ecansya 150 mg filmovertrukne tabletter Hypromellose (6cps)
English: • Grade 2 -1st appearance
Danish: • Grad 2 ved 1. forekomst
English: Hypokalaemia, Appetite disorder, Malnutrition, Hypertriglyceridaemia
Danish: Diabetes, Hypokaliæmi, Appetitforstyrrelser, Underernæring, Hypertriglyceridæmi
English: Atrial fibrillation, Cardiac ischaemia/infarction
Danish: Atrieflimren, Iskæmisk hjertesygdom/infarkt
English: In patients with unrecognised DPD deficiency treated with capecitabine as well as in those patients who test negative for specific DPYD variations, life-threatening toxicities manifesting as acute overdose may occur (see section 4.9).
Danish: Livstruende toksicitet, der manifesterer sig som akut overdosis, kan forekomme hos patienter med uopdaget DPD-mangel ved behandling med capecitabin samt hos de patienter, der testes negative for specifikke DPYD-variationer (se pkt.
English: Lacrimal duct stenosis (rare), Corneal disorders(rare), keratitis (rare), punctate keratitis (rare)
Danish: Stenosis canaliculus lacrimalis (sjælden), Hornhindesygdom (sjælden), Keratitis (sjælden), Punktat keratitis (sjælden)
English: P=0.30
Danish: 12,1 måneder p = 0,30
English: In monkeys, abortion and embryolethality were observed at high doses,
Danish: Hos aber blev der set abort og embryoletalitet efter høje doser, men der var ikke tegn på teratogenicitet.
English: Parameter: Progression-free Survival PPP
Danish: Parameter: Progressionsfri overlevelse EPP ITT
English: Blister, Skin ulcer, Rash, Urticaria, Photosensitivity reaction, Palmar erythema, Swelling face, Purpura, Radiation recall syndrome
Danish: Fotosensitivitetsreaktioner, Palmart erythem, Hævelse i ansigtet, Purpura, Recall fænomen ved strålebehandling
English: It has been reported that the DPYD*2A, c.1679T>G variants lead to a greater reduction in enzymatic activity than the other variants with a higher risk of side effects.
Danish: Der er ikke tilstrækkelige data til at anbefale en bestemt dosis til patienter med delvis DPD-aktivitet, målt ved en specifik test. Der er rapporteret at DPYD*2A, c.1679T>G varianter førte til en større reduction i enzymaktivitet end andre varianter, med en højere forekomst af bivirkninger til følge.
English: Flushing, Hypotension, Hypertensive crisis, Hot flush, Phlebitis
Danish: Ansigtsrødme, Hypotension, Hypertensiv krise, Hedetur, Flebitis
English: In the instance of exposure to crushed or cut capecitabine tablets, the following adverse drug reactions have been reported: eye irritation, eye swelling, skin rash, headache, paresthesia, diarrhea, nausea, gastric irritation, and vomiting.
Danish: Eksponering for delte eller knuste capecitabin-tabletter Skulle eksponering for delte eller knuste capecitabin-tabletter hænde, er følgende bivirkninger observeret: øjenirritation, hævelse af øjnene, hududslæt, hovedpine, parestæsi, diarré, kvalme, maveirritaiton samt opkast.
English: INFORMATION IN BRAILLE Ecansya 150 mg
Danish: INFORMATION I BRAILLE-SKRIFT Ecansya 150 mg
English: INFORMATION IN BRAILLE Ecansya 500 mg
Danish: INFORMATION I BRAILLE-SKRIFT Ecansya 500 mg
English: Ecansya 500 mg film-coated tablets Each film-coated tablet contains 500 mg capecitabine.
Danish: Ecansya 500 mg filmovertrukne tabletter Hver filmovertrukket tablet indeholder 500 mg capecitabin.
English: Pyrexia, Weakness, Lethargy, Temperature intolerance
Danish: Pyreksi, Svaghed, Letargi,
English: Ecansya 300 mg film-coated tablets Each film-coated tablet contains 300 mg capecitabine.
Danish: Ecansya 300 mg filmovertrukne tabletter Hver filmovertrukket tablet indeholder 300 mg capecitabin.
English: Diarrhoea (see section 4.4):
Danish: Diarré (se pkt.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia
Danish: NAVN OG ADRESSE PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenien
English: In addition to the ADRs described in tables 4 and 5, the following ADRs with an incidence of less than 0.1% were associated with the use of capecitabine monotherapy based on a pooled analysis from clinical safety data from 7 clinical trials including 949 patients (2 phase III and 5 phase II clinical trials in metastatic colorectal cancer and metastatic breast cancer): cardiomyopathy, cardiac failure, sudden death, and ventricular extrasystoles.
Danish: Bivirkningerne er baseret på en samlet analyse af kliniske sikkerhedsdata fra 7 kliniske studier med 949 patienter (2 fase III- og 5 fase II-kliniske studier i metastatisk kolorektalkræft og metastatisk brystkræft) og omfatter: kardiomyopati, hjerteinsufficiens, dødsfald og ventrikulære ekstrasystoler.
English: - Ecansya 300 mg film-coated tablets Hypromellose (6cps)
Danish: - Ecansya 300 mg filmovertrukne tabletter Hypromellose (6cps)
English: In the EORTC study patients were randomised to receive either open label FOLFIRI (n=41) or XELIRI (n=44) with additional randomisation to either double-blind treatment with celecoxib or placebo.
Danish: I EORTC-studiet blev patienterne randomiseret til ublindet at få enten FOLFIRI (n=41) eller XELIRI (n=44).
English: Anhydrous lactose, croscarmellose sodium, hypromellose (E-5), microcrystalline cellulose, magnesium stearate.
Danish: - Øvrige indholdsstoffer (hjælpestoffer): Tabletkernen Vandfri lactose, croscarmellosenatrium, hypromellose (E-5), mikrokrystallinsk cellulose,
English: • Grade 4 -1st appearance
Danish: • Grad 4 ved 1. forekomst
English: Combination therapy in second-line treatment of metastatic colorectal cancer Data from a multicentre, randomised, controlled phase III clinical study (NO16967) support the use of capecitabine in combination with oxaliplatin for the second-line treatment of metastastic colorectal cancer.
Danish: Kombinationsterapi i 2. linjebehandling af metastatisk kolorektalkræft Data fra et multicenter, randomiseret, kontrolleret klinisk fase III-studie (NO16967) understøtter anvendelsen af capecitabin i kombination med oxaliplatin til 2. linjebehandling af metastatisk kolorektalkræft.
English: (neuropathy) - if you have calcium imbalances (seen in blood tests) - if you have diabetes - if you cannot keep food or water in your body because of severe nausea and vomiting - if you have diarrhoea - if you are or become dehydrated - if you have imbalances of ions in your blood (electrolyte imbalances, seen in tests) - if you have a history of eye problems as you may need extra monitoring of your eyes - if you have a severe skin reaction.
Danish: (DPD) - hvis du har lever- eller nyrelidelser - hvis du har eller har haft problemer med hjertet (for eksempel uregelmæssig puls eller smerter i brystet eller ryggen i forbindelse med fysisk anstrengelse og på grund af problemer med blodforsyningen til hjertet) - hvis du har sygdomme i hjernen (for eksempel kræft, der har spredt sig til hjernen eller nerveskader (neuropati) - hvis du har forstyrrelser i kalkstofskiftet (kan ses ved blodprøver) - hvis du har sukkersyge - hvis du ikke kan holde på mad eller vand pga. svær kvalme og opkastning - hvis du har diarré - hvis du har eller får væskemangel - hvis du har forstyrrelser i saltbalancen i blodet (elektrolyt-ubalance kan ses ved blodprøver) - hvis du tidligere har haft problemer med øjnene, da du herved kan have brug for ekstra kontrol af dine øjne - hvis du har en alvorlig hudreaktion.
English: Dose level 1250 mg/m2 (twice daily)
Danish: Dosisniveau på 1.250 mg/m 2 (to gange dagligt)