FrancophonIA/ELRC3.0 huggingface dataset:
English: Stop taking this medicine immediately and contact a doctor or the nearest hospital straight away (see section 2).
Croatian: Odmah prestanite uzimati ovaj lijek i smjesta se javite liječniku ili u najbližu bolnicu (pogledajte dio 2.).
English: Your doctor may decide to temporarily or permanently stop your treatment with Xigduo.
Croatian: Vaš liječnik može odlučiti privremeno ili trajno prekinuti Vaše liječenje lijekom Xigduo.
English: Other medicines and Xigduo
Croatian: Drugi lijekovi i Xigduo
English: Therefore, the use of this medicinal product is not recommended during the second and third trimesters of pregnancy.
Croatian: Stoga se ne preporučuje primjena ovog lijeka tijekom drugog i trećeg tromjesečja trudnoće.
English: Very rare
Croatian: Vrlo rijetke
English: The maximum daily dose of metformin should preferably be divided into 2-3 daily doses.
Croatian: Maksimalna dnevna doza metformina trebala bi biti podjeljena u 2-3 dnevne doze.
English: If you take more Xigduo than you should
Croatian: Ako uzmete više lijeka Xigduo nego što ste trebali
English: In total, 22.4% had had diabetes for ≤ 5 years, mean duration of diabetes was 11.9 years.
Croatian: Ukupno je 22,4% bolesnika imalo šećernu bolest ≤ 5 godina, a srednje trajanje šećerne bolesti bilo je 11,9 godina.
English: If you have type 2 diabetes, your pancreas does not make enough insulin or your body is not able to use the insulin it produces properly.
Croatian: Ako imate šećernu bolest tipa 2, Vaša gušterača ne proizvodi dovoljno inzulina ili Vaše tijelo ne može pravilno iskoristiti inzulin koji proizvodi.
English: Measure your blood sugar if possible and rest.
Croatian: Ako je moguće, izmjerite Vašu razinu šećera u krvi te se odmorite.
English: Possible signs of losing too much fluid from your body are listed at the top of section 4.
Croatian: Mogući znakovi prekomjernog gubitka tekućine iz tijela navedeni su na početku dijela 4.
English: • if you are using bronchodilators (beta-2 agonists) which are used to treat asthma.
Croatian: • ako uzimate bronhodilatatore (beta-2 agoniste), koji se koriste za liječenje astme.
English: To treat diabetes:
Croatian: Kod liječenja šećerne bolesti:
English: Constipation Dry mouth
Croatian: konstipacija suha usta
English: The recommended dose is one tablet twice daily.
Croatian: Preporučena doza je jedna tableta dva puta dnevno.
English: The mean Vd ranged between 63-276 l.
Croatian: Srednji volumen distribucije (Vd) kretao se između 63 l i 276 l.
English: What Xigduo contains
Croatian: Što Xigduo sadrži
English: You should stop taking this medicine if you become pregnant, since it is not recommended during the second and third trimesters (the last six months) of pregnancy.
Croatian: Ako zatrudnite, morate prestati uzimati ovaj lijek jer se njegova primjena ne preporučuje u drugom i trećem tromjesečju trudnoće (posljednjih šest mjeseci trudnoće).
English: If you have symptoms of low blood sugar, eat glucose tablets, a high sugar snack or drink fruit juice.
Croatian: Ako imate simptome niske razine šećera u krvi, uzmite tablete glukoze, zalogaj sa visokim sadržajem šećera ili popijte voćni sok.
English: • This medicine is taken in combination with diet and exercise.
Croatian: • Ovaj se lijek uzima u kombinaciji s dijetom i tjelovježbom.
English: Do not stop taking this medicine without talking to your doctor first.
Croatian: Nemojte prestati uzimati ovaj lijek ako prethodno o tome niste razgovarali s liječnikom.
English: After an oral dose, the non-absorbed fraction recovered in faeces was 20-30%.
Croatian: Nakon primjene peroralne doze neapsorbirani dio pronađen u fecesu iznosio je 20-30%.
English: (95% CI) Difference from metformin c
Croatian: (95% CI) Razlika u odnosu na metformin c
English: This effect was observed at Week 1 of treatment and maintained in studies extended through Week 104.
Croatian: Ovaj je učinak primijećen u prvom tjednu liječenja, a održao se u ispitivanjima nastavljenima do tjedna 104.
English: To avoid overdose, do not continue taking dapagliflozin and metformin tablets, if you are taking Xigduo.
Croatian: Da biste izbjegli predoziranje, nemojte nastaviti uzimati tablete dapagliflozina i metformina ako uzimate Xigduo.
English: Plasma protein binding is negligible.
Croatian: Vezanje za proteine u plazmi je zanemarivo.
English: In clinical studies, use of metformin was associated with either a stable body weight or modest weight loss.
Croatian: U kliničkim istraživanjima upotreba metformina je bila povezana ili sa stabilnom tjelesnom težinom ili s umjerenim gubitkom tjelesne težine.
English: • if you are allergic to dapagliflozin, metformin or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični na dapagliflozin, metformin ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: p-values for the secondary endpoints and for single components are nominal.
Croatian: P-vrijednosti za sekundarne mjere ishoda i pojedinačne sastavnice su nominalne.
English: The mean age of the study population was 63.9 years, 37.4% were female.
Croatian: Srednja vrijednost dobi ispitivane populacije iznosila je 63,9 godina, a 37,4% bolesnika bilo je ženskog spola.
English: A GFR should be assessed before initiation of treatment with metformin containing medicinal products and at least annually thereafter.
Croatian: GFR treba procijeniti prije početka liječenja lijekovima koji sadrže metformin te najmanje jedanput godišnje nakon toga.
English: • Take your tablet with food.
Croatian: • Uzmite tabletu s hranom.
English: What Xigduo looks like and contents of the pack
Croatian: Kako Xigduo izgleda i sadržaj pakiranja
English: In case of suspected symptoms, the patient should stop taking Xigduo and seek immediate medical attention.
Croatian: U slučaju sumnje na simptome, bolesnik treba prestati uzimati Xigduo i odmah potražiti pomoć liječnika.
English: Use of alternative methods to monitor glycaemic control is advised.
Croatian: Preporuča se korištenje alternativnih metoda za praćenje regulacije glikemije.
English: Urinary uric acid excretion was also increased transiently (for 3-7 days) and accompanied by a sustained reduction in serum uric acid concentration.
Croatian: Izlučivanje mokraćne kiseline mokraćom također se privremeno povećalo (tijekom 3-7 dana), a bilo je praćeno trajnim smanjenjem koncentracije mokraćne kiseline u serumu.
English: • if you are taking medicines which increase urine production (diuretics).
Croatian: • ako uzimate lijekove koji povećavaju stvaranje mokraće (diuretici).
English: Your doctor will decide when you must stop and when to restart your treatment with Xigduo.
Croatian: Liječnik će odlučiti kada morate prekinuti i kada ćete nastaviti s liječenjem lijekom Xigduo.
English: If you need to have an injection of a contrast medium that contains iodine into your bloodstream, for example in the context of an X-ray or scan, you must stop taking Xigduo before or at the time of the injection.
Croatian: Ako trebate dobiti injekciju kontrastnog sredstva koje sadrži jod u krvnu žilu, na primjer, u sklopu rendgenskog snimanja ili skeniranja, morate prestati uzimati lijek Xigduo prije ili u vrijeme injekcije.
English: Frequency categories are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), and not known (cannot be estimated from the available data).
Croatian: Učestalost pojavljivanja definirana je kao: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000), i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: • This medicine is used if your diabetes cannot be controlled with other medicines used to treat diabetes.
Croatian: • Ovaj lijek se koristi ako se šećerna bolest ne može kontrolirati drugim lijekovima koji se koriste za liječenje šećerne bolesti.
English: Metformin increases the transport capacity of specific types of membrane glucose transporters (GLUT-1 and GLUT-4).
Croatian: Metformin povećava transportni kapacitet specifičnih tipova membranskih prijenosnika glukoze (GLUT-1 i GLUT-4).
English: If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule.
Croatian: Ako se ne sjetite do vremena kada je potrebno uzeti sljedeću dozu, preskočite propuštenu dozu i nastavite sa uobičajenim rasporedom doziranja.
English: • if you often get infections of the urinary tract.
Croatian: • ako često imate infekcije mokraćnih putova.
English: Ketoacidosis is a condition in which substances called ‘ketone bodies' accumulate in the blood and which can lead to a diabetic pre-coma.
Croatian: Ketoacidoza je stanje u kojem se tvari koje se nazivaju „ketonska tijela“ nakupljaju u krvi i mogu dovesti do dijabetičke predkome.
English: • Dapagliflozin works by removing excess sugar from your body via your urine and lowers the amount of sugar in your blood.
Croatian: • Dapagliflozin djeluje tako da uklanja višak šećera iz tijela preko urina i snižava količinu šećera u krvi.
English: • The recommended dose is one tablet twice a day.
Croatian: • Preporučena doza je jedna tableta dvaput na dan.
English: This medicine may cause urinary tract infections and your doctor may want to monitor you more closely.
Croatian: Ovaj lijek može uzrokovati infekcije mokraćnih putova pa će Vas liječnik možda htjeli pomnije nadzirati.
English: • if you are using corticosteroids (used to treat inflammation in diseases like asthma and arthritis) that are given by mouth, as an injection, or inhaled.
Croatian: • ako uzimate kortikosteroide (koriste se za liječenje upala kod bolesti poput astme i artritisa) koji se uzimaju kroz usta, kao injekcija ili inhalacijom.
English: If no adequate strength of Xigduo is available, individual mono-components should be used instead of the fixed dose combination.
Croatian: Ako nije dostupna odgovarajuća jačina lijeka Xigduo, potrebno je primijeniti pojedinačne komponente zasebno umjesto fiksne kombinacije.
English: More information is given below under ‘Other medicines and Xigduo'.
Croatian: Više informacija možete pronaći u nastavku, u dijelu „Drugi lijekovi i Xigduo“
English: • if you have severely reduced kidney function.
Croatian: • ako imate jako smanjenu funkciju bubrega
English: Xigduo is contraindicated in patients with:
Croatian: Xigduo je kontraindiciran u bolesnika:
English: Do not take this medicine if any of the above apply to you.
Croatian: Ne uzimajte ovaj lijek ako se bilo što navedeno iznad odnosi na Vas.
English: It may be more pronounced in patients with high blood glucose concentrations.
Croatian: Taj učinak može biti izraženiji u bolesnika s visokim koncentracijama glukoze u krvi.
English: Superiority of dapagliflozin over placebo was not demonstrated for MACE (p= 0.172).
Croatian: Superiornost dapagliflozina u odnosu na placebo nije dokazana za MACE događaje (p=0,172).
English: What you need to know before you take Xigduo
Croatian: Što morate znati prije nego počnete uzimati Xigduo
English: Of 17,160 randomised patients, 6,974 (40.6%) had established cardiovascular disease and 10,186 (59.4%) did not have established cardiovascular disease.
Croatian: Od 17 160 randomiziranih bolesnika, njih 6974 (40,6%) imalo je utvrđenu kardiovaskularnu bolest, dok njih 10 186 (59,4%) nije imalo utvrđenu kardiovaskularnu bolest.
English: • if you have recently had a heart attack or if you have heart failure or serious problems with your blood circulation or difficulties in breathing.
Croatian: • ako ste nedavno imali srčani udar, patite od zatajivanja srca, imate ozbiljne tegobe s cirkulacijom ili poteškoće s disanjem
English: Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption which may very rarely result in clinically significant vitamin B12 deficiency (e.g. megaloblastic anaemia).
Croatian: Dugoročno liječenje metforminom povezano je sa smanjenjem apsorpcije vitamina B12, što vrlo rijetko može dovesti do klinički značajnog nedostatka vitamina B12 (npr. megaloblastične anemije).
English: INNER CARTON - PART OF MULTIPACK - WITHOUT BLUE BOX
Croatian: UNUTARNJA KUTIJA - DIO VIŠESTRUKOG PAKIRANJA - BEZ PLAVOG OKVIRA
English: The number of first events for the single components are the actual number of first events for each component and does not add up to the number of events in the composite endpoint.
Croatian: Broj prvih događaja za pojedinačne sastavnice označava stvaran broj prvih događaja za svaku pojedinu sastavnicu i njihov zbroj ne odgovara broju događaja objedinjene mjere ishoda.
English: • nausea, vomiting
Croatian: • mučnina, povraćanje
English: Xigduo must be discontinued at the time of surgery with general, spinal or epidural anaesthesia.
Croatian: Xigduo se mora prekinuti u vrijeme kirurškog zahvata pod općom, spinalnom ili epiduralnom anestezijom.
English: Figure 1: Time to first occurrence of hospitalisation for heart failure or cardiovascular death
Croatian: Slika 1: Vrijeme do prvog nastupa hospitalizacije zbog zatajenja srca ili smrti zbog kardiovaskularnog uzroka
English: Avoid excessive alcohol intake while taking Xigduo since this may increase the risk of lactic acidosis (see “Warnings and precautions”).
Croatian: Izbjegavajte prekomjerni unos alkohola dok uzimate lijek Xigduo jer to može povećati rizik od laktacidoze (vidjeti dio „Upozorenja i mjere opreza“).
English: When the patient plans to become pregnant, and during pregnancy, it is recommended that diabetes is not treated with this medicinal product, but insulin be used to maintain blood glucose levels as close to normal as possible, to reduce the risk of malformations of the foetus associated with abnormal blood glucose levels.
Croatian: Kada pacijentica planira ostati trudna, i tijekom trudnoće, preporučuje se da se dijabetes ne liječi ovim lijekom nego da se primjeni inzulin kako bi se razina glukoze u krvi održavala što je moguće bliže normalnoj, kako bi se smanjio rizik malformacija fetusa koji je povezan s abnormalnom razinom glukoze u krvi.
English: • The amount of this medicine that you will take varies depending on your condition and the doses you currently take of metformin and/or individual tablets of dapagliflozin and metformin.
Croatian: • Količina ovog lijeka koju ćete uzeti ovisi o Vašem stanju te o dozama metformina i/ili pojedinačnih tableta dapagliflozina i metformina koje trenutno uzimate.
English: • if you have lost a lot of water from your body (dehydration), e.g. due to long-lasting or severe diarrhoea, or if you have vomited several times in a row.
Croatian: • ako ste izgubili mnogo vode iz organizma (dehidracija), npr. zbog dugotrajnog ili teškog proljeva, ili ako ste povraćali nekoliko puta za redom
English: • if you are taking cimetidine, a medicine used to treat stomach problems.
Croatian: • ako uzimate cimetidin, lijek koji se koristi za liječenje želučanih tegoba.
English: The most effective method to remove metformin and lactate is haemodialysis.
Croatian: Najučinkovitiji način uklanjanja metformina i laktata je hemodijalizom.
English: Combination requiring precautions for use
Croatian: Kombinacije čija primjena zahtijeva mjere opreza
English: Dapagliflozin Dapagliflozin is a highly potent (Ki: 0.55 nM), selective and reversible inhibitor of SGLT2.
Croatian: Dapagliflozin Dapagliflozin je vrlo snažan (Ki: 0,55 nM), selektivan i reverzibilan inhibitor SGLT2.
English: The following statements reflect the pharmacokinetic properties of the individual active substances of this medicinal product.
Croatian: Sljedeće tvrdnje odražavaju farmakokinetička svojstva pojedinačnih djelatnih tvari ovog lijeka.
English: • if you are taking other medicines that lower the amount of sugar in your blood such as insulin or a “sulphonylurea” medicine.
Croatian: • ako uzimate druge lijekove koji snižavaju razinu šećera u krvi kao što je inzulin ili lijek sulfonilureja.
English: • if you have “type 1 diabetes” - the type that usually starts when you are young, and your body does not produce any insulin.
Croatian: • ako imate „šećernu bolest tipa 1“ - vrstu šećerne bolesti koja se obično javlja u mladosti i kod koje tijelo uopće ne proizvodi inzulin.
English: • if you are taking medicines to lower blood pressure (anti-hypertensives) and have a history of low blood pressure (hypotension).
Croatian: • ako uzimate lijekove za snižavanje krvnog tlaka (antihipertenzive) i ranije ste patili od niskog krvnog tlaka (hipotenzije).
English: There were no clinically relevant differences in systemic exposures between White, Black or Asian races.
Croatian: Nije bilo klinički značajnih razlika u sustavnoj izloženosti između bijelaca, crnaca i ispitanika azijskog podrijetla.
English: BLISTERS (PERFORATED)
Croatian: BLISTERI (PERFORIRANI)
English: Xigduo should be given twice daily with meals to reduce the gastrointestinal adverse reactions associated with metformin.
Croatian: Xigduo se mora uzimati dvaput na dan s hranom kako bi se ublažile gastrointestinalne nuspojave povezane s metforminom.
English: The blood peak is lower than the plasma peak and appears at approximately the same time.
Croatian: Vršna koncentracija u krvi niža je nego u plazmi, a postiže se gotovo istodobno.
English: • Low blood sugar levels (hypoglycaemia), seen very commonly (may affect more than 1 in 10 people) - when taking this medicine with a sulphonylurea or other medicines that lower the amount of sugar in your blood, such as insulin.
Croatian: • Niska razina šećera u krvi (hipoglikemija) - što je vrlo česta nuspojava (može se javiti u više od 1 na 10 osoba) - kod uzimanja ovoga lijeka sa sulfonilurejom ili s drugim lijekovima koji snižavaju razinu šećera u krvi, kao što je inzulin.
English: • Necrotising fasciitis of the perineum or Fournier's gangrene, a serious soft tissue infection of the genitals or the area between the genitals and the anus, seen very rarely.
Croatian: • Nekrotizirajući fasciitis perineuma ili Fournierova gangrena, ozbiljna infekcija mekog tkiva genitalija ili područja između genitalija i anusa, što je vrlo rijetka nuspojava.
English: You may need more frequent blood glucose and kidney function tests, or your doctor may adjust the dosage of Xigduo.
Croatian: Možda ćete češće morati raditi pretrage glukoze u krvi ili testove funkcije bubrega ili će Vam liječnik trebati prilagoditi dozu lijeka Xigduo.
English: Dapagliflozin is not recommended.
Croatian: Dapagliflozin se ne preporučuje.
English: • abnormalities in liver function tests, inflammation of the liver (hepatitis)
Croatian: • abnormalnosti u nalazima funkcije jetre, upala jetre (hepatitis)
English: If acidosis of either form occurs, treatment must be stopped immediately and other appropriate corrective measures initiated.
Croatian: Utvrdi li se bilo koji oblik acidoze, mora se odmah prekinuti primjena ovog lijeka i uvesti odgovarajuće korektivne mjere.
English: HR=Hazard ratio CI=Confidence interval.
Croatian: HR = omjer hazarda; CI = interval pouzdanosti.
English: If you need to have major surgery, you must stop taking Xigduo during and for some time after the procedure.
Croatian: Ako se morate podvrgnuti velikom kirurškom zahvatu, morate prestati uzimati lijek Xigduo tijekom i još neko vrijeme nakon zahvata.
English: • If you are already taking both dapagliflozin and metformin as single tablets, your doctor may ask you to switch to this medicine.
Croatian: • Ukoliko već uzimate zasebne tablete dapagliflozina i metformina, Vaš liječnik može zatražiti da prijeđete na liječenje ovim lijekom.
English: This may be another medicine taken by mouth and/or a medicine given by injection, such as insulin or a GLP-1 receptor agonist (helps your body to increase the production of insulin when your blood sugar is high).
Croatian: To može biti neki drugi lijek koji se uzima kroz usta i/ili lijek koji se primjenjuje injekcijom, kao što je inzulin ili agonist GLP-1 receptora (pomaže vašem tijelu da poveća proizvodnju inzulina kad je razina šećera u Vašoj krvi visoka).
English: A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital malformations.
Croatian: Malobrojni podaci primjene metformina u trudnica ne pokazuju povećani rizik od prirođenih malformacija.
English: If you take more Xigduo tablets than you should, you may experience lactic acidosis.
Croatian: Ako uzmete više Xigduo tableta nego što ste trebali, može doći do pojave laktacidoze.
English: All patients had type 2 diabetes mellitus and either at least two additional cardiovascular risk factors (age ≥ 55 years in men or ≥ 60 years in women and one or more of dyslipidaemia, hypertension or current tobacco use) or established cardiovascular disease.
Croatian: Svi su bolesnici imali šećernu bolest tipa 2 i najmanje dva dodatna faktora kardiovaskularnog rizika (dob ≥ 55 godina kod muškaraca ili ≥ 60 godina kod žena te jedan ili više od sljedećih faktora: dislipidemija, hipertenzija ili trenutna konzumacija duhana) ili utvrđenu kardiovaskularnu bolest.
English: Xigduo should not be used to treat this condition.
Croatian: Xigduo se ne smije koristiti za liječenje ove bolesti.
English: CARTON - WITH BLUE BOX
Croatian: KUTIJA - S PLAVIM OKVIROM
English: The SGLT2 is selectively expressed in the kidney with no expression detected in more than 70 other tissues including liver, skeletal muscle, adipose tissue, breast, bladder and brain.
Croatian: SGLT2 je selektivno eksprimiran u bubrezima, a ekspresija nije uočena u više od 70 drugih tkiva, uključujući jetru, skeletne mišiće, masno tkivo, dojke, mokraćni mjehur i mozak.
English: Do not take Xigduo
Croatian: Nemojte uzimati Xigduo
English: Furthermore, two 12-week, placebo-controlled studies were conducted in patients with inadequately controlled type 2 diabetes and hypertension.
Croatian: Nadalje, dva 12 tjedna, placebom kontrolirana ispitivanja su provedena kod bolesnika s nedovoljno dobro reguliranom šećernom bolešću tipa 2 i hipertenzijom.
English: In humans, independently of its action on glycaemia, metformin has favourable effects on lipid metabolism.
Croatian: Neovisno o djelovanju na glikemiju, metformin u ljudi ima povoljan učinak na metabolizam lipida.
English: For metformin, studies in animals have not shown reproductive toxicity (see section 5.3).
Croatian: Istraživanja metformina na životinjama nisu ukazala na reproduktivnu toksičnost (vidjeti dio 5.3).
English: • Prior to initiation of concomitant medicinal products that may reduce renal function and periodically thereafter.
Croatian: • prije početka istodobnog liječenja lijekovima koji mogu umanjiti bubrežnu funkciju i povremeno nakon toga
English: BLISTERS (NON-PERFORATED)
Croatian: BLISTERI (NEPERFORIRANI)
English: Volume depletion includes, e.g. the predefined preferred terms: dehydration, hypovolaemia, hypotension.
Croatian: Deplecija volumena uključuje, primjerice, unaprijed određene preporučene pojmove: dehidracija, hipovolemija, hipotenzija.
English: • if you are using medicines used to treat pain and inflammation (NSAID and COX-2-inhibitors, such as ibuprofen and celecoxib).
Croatian: • lijekove koji se primjenjuju za liječenje boli i upale (NSAIL i COX-2-inhibitori, kao što su ibuprofen i celekoksib)
English: Metformin (immediate- or extended-release formulations) ≥ 1500 mg/day plus maximum tolerated dose, which must be at least half maximum dose, of a sulphonylurea for at least 8 weeks prior to enrolment.
Croatian: Metformin (oblici sa trenutnim ili produljenim oslobađanjem) ≥1500 mg/dan plus maksimalna podnošljiva doza sulfonilureje, koja mora biti najmanje pola maksimalne doze, tijekom najmanje 8 tjedana prije uključivanja u ispitivanje.
English: The patient should be informed and more frequent blood glucose monitoring perfomed, especially at the beginning of treatment with such medicinal products.
Croatian: S time treba upoznati bolesnika i češće kontrolirati glukozu u krvi, osobito na početku liječenja ovim lijekovima.
English: Renal clearance of metformin is > 400 mL/min, indicating that metformin is eliminated by glomerular filtration and tubular secretion.
Croatian: Bubrežni klirens metformina iznosi > 400 ml/min, što ukazuje na to da se metformin eliminira glomerularnom filtracijom i tubularnom sekrecijom.