FrancophonIA/ELRC3.0 huggingface dataset:
English: Retinal haemorrhage, Arteriosclerotic retinopathy, Retinal disorder, Glaucoma,
Maltese: Retinopatija arterjosklerotika, Disturb retinali, Glawkoma, Difett fil-kamp viżiv,
English: At maximum recommended doses, there is an 80-fold selectivity over PDE1, and over 700-fold over PDE2, 3, 4, 7,
Maltese: Blogħla dożi rrakkomandati, hemm selettività ta' 80 darba aktar fuq PDE1, u aktar minn 700 darba fuq PDE2, 3, 4, 7, 8, 9, 10 u 11.
English: No significant interactions were shown when sildenafil (50 mg) was co-administered with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolised by CYP2C9.
Maltese: Ma kien hemm l-ebda interazzjonijiet sinifikanti meta sildenafil (50 mg) ingħata ma' tolbutamide (250 mg) jew warfarin (40 mg), li t-tnejn li huma jiġu mmetabolizzati minn CYP2C9.
English: This is most likely to occur within 4 hours post sildenafil dosing (see sections 4.2 and 4.4).
Maltese: Dan jista' jseħħ l-aktar sa 4 sigħat wara li tittieħed id-doża ta' sildenofil (ara sezzjonijiet 4.2 u 4.4).
English: Stevens-Johnson Syndrome (SJS)*, Toxic Epidermal Necrolysis (TEN)*
Maltese: Sindromu ta' Stevens-Johnson (SJS),
English: Sildenafil ratiopharm 25 mg film-coated tablets EU/1/09/603/001
Maltese: Sildenafil ratiopharm 25 mg pilloli miksija b'rita EU/1/09/603/001
English: Sildenafil (50 mg) did not potentiate the increase in bleeding time caused by acetyl salicylic acid (150 mg).
Maltese: Sildenafil (50 mg) ma saħħaħx iż-żieda fil-ħin tal-ħruġ ta' demm ikkaġunat minn acetyl salicylic acid (150 mg).
English: This is consistent with ritonavir's marked effects on a broad range of P450 substrates.
Maltese: Dan hu konsistenti mal-effetti sinifikanti ta' ritonavir fuq medda wiesgħa ta' substrati ta' P450.
English: EU/1/09/603/005 1 film-coated tablet EU/1/09/603/006 4 film-coated tablets EU/1/09/603/007 8 film-coated tablets EU/1/09/603/008 12 film-coated tablets EU/1/09/603/014 2 film-coated tablets EU/1/09/603/017 24 film-coated tablets
Maltese: EU/1/09/603/005 1 pillola miksija b'rita EU/1/09/603/006 4 pilloli miksija b'rita EU/1/09/603/007 8 pilloli miksija b'rita EU/1/09/603/008 12-il pillola miksija b'rita EU/1/09/603/014 2-il pillola miksija b'rita EU/1/09/603/017 24 pillola miksija b'rita
English: Sildenafil ratiopharm 100 mg film-coated tablets EU/1/09/603/009
Maltese: Sildenafil ratiopharm 100 mg pilloli miksija b'rita EU/1/09/603/009
English: Posology Use in adults
Maltese: L-użu fl-adulti
English: Single doses of antacid (magnesium hydroxide/aluminium hydroxide) did not affect the bioavailability of sildenafil.
Maltese: Dożi waħidhom ta' mediċina kontra l-aċidu fl-istonku (magnesium hydroxide/ aluminium hydroxide) ma affettwawx il-bijodisponibilità ta' sildenafil.
English: Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route).
Maltese: Il-metaboliżmu ta' sildenafil iseħħ l-aktar permezz tal-iżoformi ta' ċitokrom P450 (CYP) 3A4 (rotta ewlenija) u 2C9 (rotta minuri).
English: In these study populations, mean additional reductions of supine blood pressure of 7/7 mmHg, 9/5 mmHg, and 8/4 mmHg, and mean additional reductions of standing blood pressure of 6/6 mmHg, 11/4 mmHg, and 4/5 mmHg, respectively, were observed.
Maltese: F'dawn il-popolazzjonijiet tal-istudji, kien osservat tnaqqis addizzjonali medju tal-pressjoni tad-demm meta kienu mimdudin ta' 7/7 mmHg, 9/5 mmHg u 8/4 mmHg rispettivament u tnaqqis addizzjonali medju ta' 6/6 mmHg, 11/4 mmHg u 4/5 mmHg tal-pressjoni tad-demm meta kienu bilwieqfa.
English: Mean pulmonary systolic blood pressure decreased by 9%.
Maltese: Il-medja tal-pressjoni pulmonari sistolika tad-demm naqset b'9%.
English: Pharmacotherapeutic group: Urologicals; Drugs used in erectile dysfunction, ATC code: G04BE03
Maltese: Uroloġiċi: Pilloli użati għal disfunzjoni erettili, Kodiċi ATC:
English: Sildenafil ratiopharm will only work when you are sexually stimulated.
Maltese: Sildenafil ratiopharm ser jaħdem biss meta tkun stimulat sesswalment.
English: Sildenafil ratiopharm 50 mg film-coated tablets EU/1/09/603/005
Maltese: Sildenafil ratiopharm 50 mg pilloli miksija b'rita EU/1/09/603/005
English: Co-administration of the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg twice daily) with sildenafil (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil Cmax and a 1,000% (11-fold) increase in sildenafil plasma AUC.
Maltese: L-għoti flimkien ma' l-inibitur ta' HIV protease ritonavir, li hu inibitur potenti ħafna ta' P450, fl-istat stabbli (500 mg darbtejn kuljum) ma' sildenafil (100 mg doża waħda) irriżulta f'żieda ta' 300% (4 darbiet) fis-Cmax ta' sildenafil u żieda ta' 1,000% (11-il darba) fl-AUC tal-plażma ta' sildenafil.
English: Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes.
Maltese: Sildenafil jitneħħa primarjament mill-iżoenzimi mikrożomali CYP3A4 (rotta ewlenija) u CYP2C9 (rotta minuri) tal-fwied.
English: INFORMATION IN BRAILLE Sildenafil ratiopharm 25 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Sildenafil ratiopharm 25 mg
English: In a penile plethysmography (RigiScan) study of fasted patients, the median time to onset for those who obtained erections of 60% rigidity (sufficient for sexual intercourse) was 25 minutes (range 12-37 minutes) on sildenafil.
Maltese: Fi studju dwar ilpletismografija tal-pene (RigiScan) f'pazjenti sajmin, il-ħin medjan biex jibdew l-erezzjonijiet li kellhom riġidità ta' 60% (suffiċjenti għall-att sesswali) kien ta' 25 minuta (medda ta' 12-37 minuta) b'sildenafil.
English: EU/1/09/603/001 1 film-coated tablet EU/1/09/603/002 4 film-coated tablets EU/1/09/603/003 8 film-coated tablets EU/1/09/603/004 12 film-coated tablets EU/1/09/603/013 2 film-coated tablets
Maltese: EU/1/09/603/001 1 pillola miksija b'rita EU/1/09/603/002 4 pilloli miksija b'rita EU/1/09/603/003 8 pilloli miksija b'rita EU/1/09/603/004 12-il pillola miksija b'rita EU/1/09/603/013 2-il pillola miksija b'rita
English: INFORMATION IN BRAILLE Sildenafil ratiopharm 100 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Sildenafil ratiopharm 100 mg
English: Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM).
Maltese: Minħabba li sildenafil (u l-metabolit maġġuri tiegħu fiċ-ċirkolazzjoni N-desmethyl) hu 96% marbut ma' proteini tal-plażma, dan jirriżulta fil-medja tal-ogħla konċentrazzjoni ta' plażma ħielsa għal sildenafil ta' 18 ng/mL (38 nM).
English: Sudden cardiac death*, Myocardial infarction, Ventricular arrhythmia*, Atrial fibrillation, Unstable angina
Maltese: Mewta kardijaka għall-għarrieda, Infart mijokardijaku, Arritmija ventrikulari, Fibrillazzjoni atrijali, Anġina instabbli
English: In healthy volunteers receiving sildenafil (100 mg single dose), less than 0.0002% (average 188 ng) of the administered dose was present in ejaculate 90 minutes after dosing.
Maltese: F'voluntiera b'saħħithom li ħadu sildenafil (doża waħda ta' 100 mg), inqas minn 0.0002% (medja ta' 188 ng) tad-doża mogħtija, kienet preżenti fl-isperma 90 minuta wara d-doża.
English: (≥ 1/100 and
Maltese: Komuni (≥ 1/100 u
English: NAME OF THE MEDICINAL PRODUCT Sildenafil ratiopharm 25 mg film-coated tablets Sildenafil ratiopharm 50 mg film-coated tablets Sildenafil ratiopharm 100 mg film-coated tablets
Maltese: Sildenafil ratiopharm 25 mg pilloli miksija b'rita Sildenafil ratiopharm 50 mg pilloli miksija b'rita Sildenafil ratiopharm 100 mg pilloli miksija b'rita
English: What Sildenafil ratiopharm contains - The active substance is sildenafil.
Maltese: X'fih Sildenafil ratiopharm - Is-sustanza attiva hi sildenafil.
English: The mean steady state volume of distribution (Vd) for sildenafil is 105 l, indicating distribution into the tissues.
Maltese: Il-medja tal-volum ta' distribuzzjoni fl-istat fiss (Vd) għal sildenafil hu ta' 105 l, li jindika distribuzzjoni fit-tessuti.
English: In a study of the haemodynamic effects of a single oral 100 mg dose of sildenafil in 14 patients with severe coronary artery disease (CAD) (> 70% stenosis of at least one coronary artery), the mean resting systolic and diastolic blood pressures decreased by 7% and 6% respectively compared to baseline.
Maltese: Fi studju dwar l-effetti emodinamiċi ta' doża waħda orali ta' 100 mg ta' sildenafil f'14-il pazjent b'mard sever tal-arterji koronarji (CAD) (> 70% stenożi f'mill-inqas arterja koronarja waħda), ilpressjoni sistolika u dijastolika medja tad-demm waqt is-serħan naqsu b'7% u 6% rispettivament, meta mqabbla mal-linja bażi.
English: A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products (except nitrates).
Maltese: Prova ta' stress waqt l-eżerċizzju, double-blind, ikkontrollata bi plaċebo, evalwat 144 pazjent b'disfunzjoni erettili u anġina stabbli kronika li regolarment irċivew mediċini kontra l-anġina (ħlief nitrates).
English: INFORMATION IN BRAILLE Sildenafil ratiopharm 50 mg
Maltese: INFORMAZZJONI BIL-BRAILLE Sildenafil ratiopharm 50 mg
English: In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62% (25 mg), 74% (50 mg) and 82% (100 mg) compared to 25% on placebo.
Maltese: Fi studji dwar doża fissa, il-proporzjonijiet ta' pazjenti li rrappurtaw li l-kura tejbet l-erezzjonijiet tagħhom kienu 62% (25 mg), 74% (50 mg), u 82% (100 mg) meta mqabbla ma' 25% li kienu qed jieħdu l-plaċebo.
English: Table 1: Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through postmarketing surveillance
Maltese: Tabella 1: Reazzjonijiet avversi ta' importanza medika b'inċidenza ta' rapporti akbar minn plaċebo fi studji kliniċi kkontrollati, u reazzjonijiet avversi ta' importanza medika rrappurtati minn sorveljanza ta' wara t-tqegħid tal-prodott fis-suq
English: Pooling of the following classes of antihypertensive medication, diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products (vasodilator and centrally-acting), adrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment.
Maltese: Il-ġbir tal-klassijiet li ġejjin ta' mediċini ta' kontra l-pressjoni għolja, dijuretiċi, beta-blockers, inibituri ta' ACE, antagonisti ta' angiotensin II, prodotti mediċinali kontra l-pressjoni għolja (lokalment fuq l-arterji jew fuq is-sistema ċentrali), adrenergic neurone blockers, channel blockers talcalcium u alpha-adrenoceptor blockers, ma wrew l-l-ebda differenza fil-profil ta' effetti sekondarji f'pazjenti li jkunu ħadu sildenafil meta mqabbla ma' kura bil-plaċebo.
English: In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n = 9), sildenafil (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress).
Maltese: Fi studju żgħir ikkontrollat bilplaċebo ta' pazjenti b'deġenerazzjoni makulari bikrija dokumentata relatata mal-età (n=9), sildenafil (doża waħda, 100 mg) ma wera l-ebda tibdil sinifikanti fit-testijiet tal-viżta li saru (ċarezza tal-viżta, Amsler grid, diskriminazzjoni ta' kulur ta' dwal tat-traffiku simulati, Humphrey perimeter u photostress).
English: Other medicines and Sildenafil ratiopharm
Maltese: Mediċini oħra u Sildenafil ratiopharm
English: Effects of other medicinal products on sildenafil In vitro studies
Maltese: Effetti ta' prodotti mediċinali oħra fuq sildenafil
English: Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.
Maltese: Dożi orali waħidhom ta' sildenafil sa 100 mg f'voluntiera b'saħħithom ma pproduċew l-ebda effett klinikalment rilevanti fuq l-ECG.
English: If you are taking ritonavir, you may not exceed a maximum dose of 25 mg sildenafil within a period of 48 hours.
Maltese: Jekk qed tieħu ritonavir, ma tistax taqbeż doża massima ta' 25 mg ta' sildenafil f'perijodu ta' 48 siegħa.
English: This medicine is used to treat pulmonary arterial hypertension (i.e. high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e. high blood pressure in the lungs secondary to blood clots).
Maltese: Din il-mediċina tintuża għat-trattament tal-ipertensjoni arterjali pulmonarja (i.e., pressjoni għolja tad-demm fil-pulmuni) u ipertensjoni pulmonarja tromboembolika kronika (i.e., pressjoni għolja tad-demm fil-pulmuni kkawżata minn ċapep fiddemm).
English: This medicine will only help you to get an erection if you are sexually stimulated.
Maltese: Din il-mediċina se tgħinek tikseb erezzjoni jekk tkun sesswalment stimulat biss.
English: When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%.
Maltese: Meta sildenafil jittieħed mal-ikel, ir-rata ta' assorbiment titnaqqas b'dewmien medju fit-tmax ta' 60 minuta u tnaqqis medju fis-Cmax ta' 29%.
English: Luxembourg/Luxemburg ratiopharm GmbH, Allemagne/Deutschland Tél/Tel: +49 731 402 02
Maltese: Luxembourg/Luxemburg ratiopharm GmbH, Allemagne/Deutschland
English: In addition, N-desmethyl metabolite AUC and Cmax values were significantly increased by 200% and 79% respectively.
Maltese: Barra minn dan, il-valuri tal-AUC u tas-Cmax tal-metabolit N-desmethyl żdiedu b'mod sinifikanti b'200% u 79% rispettivament.
English: Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro.
Maltese: Studji bi plejtlits fil-bniedem jindikaw li sildenafil isaħħaħ l-effett kontra l-aggregazzjoni ta' sodium nitroprusside in vitro.
English: These symptoms usually occur within 4 hours of taking Sildenafil ratiopharm.
Maltese: Dawn issintomi normalment iseħħu fi żmien 4 sigħat minn x'ħin tkun ħadt Sildenafil ratiopharm.
English: Sildenafil ratiopharm 50 mg film-coated tablets Pack sizes of 1, 2, 4, 8, 12 or 24 film-coated tablets.
Maltese: Sildenafil ratiopharm 50 mg pilloli miksija b'rita Daqs tal-pakketti ta' 1, 2, 4, 8, 12 jew 24 pilloli miksija b'rita.
English: After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range (25-100 mg).
Maltese: Wara doża orali ta' sildenafil, l-AUC u s-Cmax jiżdiedu fi proporzjon mad-doża fuq il-medda rrakkomandata tad-doża (25-100 mg).
English: In volunteers with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min), the pharmacokinetics of sildenafil were not altered after receiving a 50 mg single oral dose.
Maltese: F'voluntiera b'indeboliment tal-kliewi minn ħafif sa moderat (tneħħija tal-krejatinina = 30-80 mL/min), il-farmakokinetika ta' sildenafil ma nbidlitx wara doża orali waħda ta' 50 mg.
English: Effects of sildenafil on other medicinal products In vitro studies
Maltese: Effetti ta' sildenafil fuq prodotti mediċinali oħra
English: Pharmacokinetics in special patient groups Elderly
Maltese: Farmakokinetika fi gruppi speċjali ta' pazjenti
English: When a single 100 mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg twice daily for 5 days), there was a 182% increase in sildenafil systemic exposure (AUC).
Maltese: Meta doża waħda ta' 100 mg ta' sildenafil ingħatat ma' erythromycin, inibitur moderat ta' CYP3A4, fl-istat fiss (500 mg darbtejn kuljum għal 5 ijiem), kien hemm żieda ta' 182% fl-espożizzjoni sistemika (AUC) ta' sildenafil.
English: Sildenafil potentiates the hypotensive effect of nitrates (see section 4.3).
Maltese: Sildenafil isaħħaħ l-effett ipotensiv tan-nitrates (ara sezzjoni 4.3).
English: 1 film-coated tablet 2 film-coated tablets 4 film-coated tablets 8 film-coated tablets 12 film-coated tablets 24 film-coated tablets 48 film-coated tablets
Maltese: 1 pillola miksija b'rita 2 pilloli miksija b'rita 4 pilloli miksija b'rita 8 pilloli miksija b'rita 12-il pillola miksija b'rita 24 pillola miksija b'rita 48 pillola miksija b'rita
English: Nausea, Dyspepsia
Maltese: Dardir, Dispepsja
English: After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%).
Maltese: Wara doża orali waħda ta' 100 mg, il-medja tal-ogħla konċentrazzjoni totali fil-plażma ta' sildenafil hi ta' madwar 440 ng/mL (CV 40%).
English: Taking Sildenafil ratiopharm together with some medicines may lead to problems.
Maltese: Li tieħu Sildenafil ratiopharm flimkien ma' xi mediċini jista' jwassal għal problemi.
English: Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects.
Maltese: Inibituri ta' CYP3A4 aktar b'saħħithom bħal ketoconazole u itraconazole huma mistennija li jkollhom effetti akbar.
English: Consistent with its known effects on the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway (see section 5.1), sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitric oxide donors (such as amyl nitrite) or nitrates in any form is therefore contraindicated.
Maltese: Konsistenti mal-effetti magħrufa tiegħu fuq ir-rotta tal-metaboliżmu ta' nitric oxide/cyclic guanosine monophosphate (cGMP) (ara sezzjoni 5.1), intwera li sildenafil isaħħaħ l-effetti ipotensivi tan-nitrati, u l-għoti flimkien ma' donaturi ta' nitric oxide (bħal amyl nitrite) jew nitrati f'xi forma oħra hu għalhekk kontraindikat.
English: In volunteers with mild to moderate hepatic cirrhosis (Child-Pugh A and B) sildenafil clearance was reduced, resulting in increases in AUC (84%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment.
Maltese: F'voluntiera b'ċirrożi tal-fwied minn ħafifa sa moderata (Child-Pugh A u B) it-tneħħija ta' sildenafil tnaqqset, u dan irriżulta f'żidiet fl-AUC (84%) u fis-Cmax (47%) meta mqabbla ma' voluntiera tal-istess età li ma kellhomx indeboliment tal-fwied.
English: - if you have a severe liver problem.
Maltese: - jekk għandek problema severa tal-fwied.
English: The major circulating metabolite results from N-demethylation of sildenafil.
Maltese: Il-metabolit ewlieni li jiċċirkola jirriżulta minn N-demethylation ta' sildenafil.
English: The dosing recommendations described in ‘Use in adults' apply to patients with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min).
Maltese: Ir-rakkomandazzjonijiet ta' dożaġġi mfissra fl-“L-użu fl-adulti” japplikaw għal pazjenti b'indeboliment tal-kliewi ħafif sa moderat (tneħħija tal-krejatinina = 30-80mL/min).
English: In healthy male volunteers, sildenafil at steady state (80 mg t.i.d.)
Maltese: F'voluntiera rġiel b'saħħithom, sildenafil fi stat fiss (80mg t.i.d.) irriżulta f'żieda ta' 49.
English: Visual colour distortions**, Visual disturbance, Vision blurred
Maltese: Disturbi filvista, Vista mċajpra,
English: PDE5 inhibitors, such as sildenafil, have been shown to increase the hypotensive effects of this medicine.
Maltese: Ġie muri li inibituri ta' PDE5, bħal sildenafil, iżidu l-effetti ipotensivi ta' din ilmediċina.
English: In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC, Cmax, tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite.
Maltese: F'voluntiera rġiel normali b'saħħithom, ma kien hemm l-ebda evidenza ta' xi effett ta' azithromycin (500 mg kuljum għal 3 ijiem) fuq l-AUC, Cmax u tmax, il-valur kostanti tarrata tal-eliminazzjoni jew il-half-life sussegwenti ta' sildenafil jew tal-metabolit prinċipali tiegħu fiċċirkolazzjoni.
English: Cerebrovascular accident,
Maltese: Emorraġija filpene,
English: These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle.
Maltese: Dan it-tnaqqis fil-pressjoni taddemm hu konsistenti mal-effetti ta' vażodilatazzjoni ta' sildenafil, probabbilment minħabba żieda fillivelli ta' cGMP fil-muskolu lixx vaskulari.
English: Uncommon (may affect up to 1 in 100 people): vomiting, skin rash, eye irritation, bloodshot eyes/red eyes, eye pain, seeing flashes of light, visual brightness, light sensitivity, watery eyes, pounding heartbeat, rapid heartbeat, high blood pressure, low blood pressure, muscle pain, feeling sleepy, reduced sense of touch, vertigo, ringing in the ears, dry mouth, blocked or stuffy sinuses, inflammation of the lining of the nose (symptoms include runny nose, sneezing and stuffy nose), upper abdominal pain, gastro-oesophageal reflux disease (symptoms include heartburn), presence of blood in urine, pain in the arms or legs, nosebleed, feeling hot and feeling tired.
Maltese: Mhux komuni (jistgħu' jaffettwaw sa persuna 1 minn kull 100): rimettar, raxx, irritazzjoni fl-għajnejn, għajnejn ħomor, uġigħ fl-għajn, tara leħħiet ta' dawl bħal berqa, luminożità viżiva, sensittività għaddawl, għajnejn idemmgħu, taħbit qawwi tal-qalb, taħbit tal-qalb mgħaġġel, pressjoni għolja, pressjoni baxxa, uġigħ fil-muskoli, ngħas tqil, tnaqqis fis-sens tal-mess, vertigo, tisfir fil-widnejn, ħalq xott, imnifsejn imblukkati jew mimlijin, infjammazzjoni tar-rita tal-imnieħer (sintomi jinkludu tnixxija, għatis u sadda), uġigħ addominali fil-parti ta' fuq, mard tar-rifluss gastro-esofaġeali (sintomi jinkludu ħruq ta' stonku), preżenza ta' demm fl-awrina, uġigħ fid-dirgħajn u r-riġlejn, fsada fl-imnieħer, sensazzjoni ta' sħana u għeja.
English: The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina.
Maltese: Ir-riżultati wrew li ma kien hemm l-ebda differenza klinikament rilevanti bejn sildenafil u plaċebo fil-ħin ta' limitazzjoni għal anġina.
English: The mean maximum decreases in supine systolic blood pressure following 100 mg oral dosing of sildenafil was 8.4 mmHg.
Maltese: Il-medja tan-tnaqqis massimu fil-pressjoni sistolika f'pożizzjoni mimduda wara doża orali ta' 100 mg ta' sildenafil kienet ta' 8.4 mmHg.
English: - Chest pains - this occurs uncommonly.
Maltese: Uġigħ fis-sider - dan iseħħ b'mod mhux komuni.
English: The physiological mechanism responsible for erection of the penis involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation.
Maltese: Il-mekkaniżmu fiżjoloġiku responsabbli għal erezzjoni tal-pene jinvolvi l-ħruġ ta' nitric oxide (NO) fil-corpus cavernosum waqt stimulazzjoni sesswali.
English: Sildenafil had no effect on ritonavir pharmacokinetics.
Maltese: Sildenafil ma kellu l-ebda effett fuq il-farmakokinetika ta' ritonavir.
English: In volunteers with severe renal impairment (creatinine clearance < 30 mL/min), sildenafil clearance was reduced, resulting in mean increases in AUC and Cmax of 100% and 88% respectively compared to age-matched volunteers with no renal impairment.
Maltese: F'voluntiera b'indeboliment sever tal-kliewi (tneħħija tal-krejatinina ta' < 30mL/min), it-tneħħija ta' sildenafil naqset, u wasslet għal żidiet medji tal-AUC u tas-Cmax ta' 100% u 88% rispettivament meta mqabbla ma' voluntiera tal-istess età li ma kellhomx indeboliment tal-kliewi.
English: Therefore, tell your doctor if you are taking any of the following medicines: - ritonavir or saquinavir (medicines for the treatment of HIV infections); - ketoconazole or itraconazole (medicines for the treatment of fungal infections); - erythromycin (an antibiotic); - cimetidine (medicine for the treatment of heartburn and peptic ulcers);
Maltese: - ketoconazole jew itraconazole (mediċini għall-kura ta' infezzjonijiet fungali); - erythromycin (antibijotiku); - cimetidine (mediċina għall-kura ta' qrusa fl-istonku u ulċeri peptiċi); - alpha blockers (grupp ta' mediċini għall-kura ta' pressjoni tad-demm għolja jew prostata mkabbra [iperplasija prostatika beninna]).