FrancophonIA/ELRC3.0 huggingface dataset:
English: Lixisenatide has no or negligible influence on the ability to drive or use machines.
Croatian: Liksisenatid ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: How to activate your new Lyxumia pen Step 1 Pull off the pen cap and check the pen
Croatian: Kako aktivirati novu Lyxumia brizgalicu Korak 1 Skinite zatvarač brizgalice i pregledajte brizgalicu
English: - you suffer from heart problems which can cause shortness of breath or ankle swelling, since there is limited experience in this population.
Croatian: - imate srčane probleme koje mogu izazvati nedostatak zraka ili oticanje gležnjeva, jer je iskustvo s primjenom lijeka u ovoj populaciji ograničeno
English: New pen (orange window)
Croatian: Nova brizgalica (narančasti prozorčić)
English: • Beta cell function
Croatian: • Funkcija beta stanica
English: If such medicinal products are to be administered with food, patients should be advised to, if possible, take them with a meal when lixisenatide is not administered.
Croatian: Ako se takvi lijekovi moraju uzimati s hranom, bolesnicima treba savjetovati da ih po mogućnosti uzimaju uz onaj obrok uz koji ne primjenjuju liksisenatid.
English: The majority of injection site reactions were mild, regardless of antibody status.
Croatian: Većina reakcija na mjestu injekcije bila je blaga, neovisno o statusu protutijela.
English: • Severe and persistent pain in the abdomen (stomach area) which might reach through to your back, as well as nausea and vomiting, as it could be a sign of an inflamed pancreas
Croatian: • Jaka bol u abdomenu (područje trbuha) koja ne prestaje i koja se može protegnuti do leđa, kao i mučnina i povraćanje, koji mogu biti znakovi upale gušterače (pankreatitis)
English: Grasp a fold of skin and insert the needle (see the “Injection sites” section about where to inject).
Croatian: Uhvatite nabor kože i zabodite iglu (vidjeti dio "Mjesta za injiciranje" da biste doznali gdje možete injicirati lijek).
English: • Throw away your Lyxumia pen, ask your pharmacist how to throw away medicines you no longer use.
Croatian: • Bacite Lyxumia brizgalicu; pitajte svog ljekarnika kako baciti lijekove koje više ne koristite.
English: Do not share them with anyone else.
Croatian: Nemojte ih dijeliti ni s jednom drugom osobom.
English: Lyxumia must be injected under the skin and can be injected in any of the areas shown above in blue.
Croatian: Lyxumia se mora injicirati pod kožu, a to se može učiniti na bilo kojem području koje je na slici označeno plavom bojom.
English: • These pens are only for one person.
Croatian: • Brizgalice su namijenjene samo za jednu osobu.
English: The reduction in Cmax is of limited clinical relevance and no dose adjustment for oral contraceptives is required.
Croatian: Smanjenje vrijednosti Cmax ima ograničen klinički značaj i ne zahtijeva prilagodbu doze oralnih kontraceptiva.
English: Pull the injection button out firmly until it stops.
Croatian: Čvrsto izvucite dugme za injiciranje dok se ne zaustavi.
English: Point the needle into a suitable container (like a paper cup or tissue) to capture the liquid so that it can be thrown away.
Croatian: Usmjerite iglu prema prikladnom spremniku (poput papirnate čaše ili rupčića) kako biste u njega izbacili tekućinu koju ćete zatim baciti.
English: The most frequently reported adverse reactions during clinical studies were nausea, vomiting and diarrhoea.
Croatian: Najčešće prijavljene nuspojave tijekom kliničkih ispitivanja bile su mučnina, povraćanje i proljev.
English: (for example, if you have vision problems), only use it if you have help.
Croatian: ako imate problema s vidom), brizgalicu upotrijebite samo uz nečiju pomoć.
English: As opposed to both insulin glulisine treatment regimens, lixisenatide reduced body weight (table 5).
Croatian: Za razliku od oba režima liječenja inzulinom glulizinom, liksisenatid je smanjio tjelesnu težinu (tablica 5).
English: There was no cross-reactivity versus either native glucagon or endogenous GLP-1.
Croatian: Nije primijećena križna reaktivnost naspram prirodnog glukagona ili endogenog GLP-1.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Lyxumia in one or more subsets of the paediatric population in type 2 diabetes mellitus (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Lyxumia u jednoj ili više podskupina pedijatrijske populacije u šećernoj bolesti tipa 2 (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: Step F. Repeat all steps in Section 3 for each injection.
Croatian: Ponovite sve korake iz dijela 3 za svaku injekciju.
English: The Lyxumia Treatment Initiation pack includes two different coloured pens.
Croatian: Lyxumia pakiranje za početak liječenja uključuje dvije brizgalice različitih boja.
English: Patients should be informed of the characteristic symptoms of acute pancreatitis: persistent, severe abdominal pain.
Croatian: Bolesnike treba informirati o karakterističnim simptomima akutnog pankreatitisa: jaka bol u abdomenu koja ne prestaje.
English: Nausea and vomiting were the most frequently reported adverse reactions during the main 24-week treatment period.
Croatian: Mučnina i povraćanje bile su najčešće prijavljene nuspojave tijekom osnovnog 24-tjednog razdoblja liječenja.
English: • oral antidiabetics (such as metformin, pioglitazone, sulphonylurea medicines) and/ or ,
Croatian: • oralni antidijabetici (poput metformina, pioglitazona, lijekova derivata sulfonilureje) i/ili
English: The percentage of patients who were antibody positive was similar at the end of the entire 76-week treatment period.
Croatian: Postotak bolesnika koji su bili pozitivni na protutijela bio je sličan i na kraju ukupnog 76-tjednog razdoblja liječenja.
English: - you are also taking a sulphonylurea or a basal insulin.
Croatian: - također uzimate sulfonilureju ili bazalni inzulin.
English: If this happens do not drive or use any tools or machines.
Croatian: Ako se to dogodi, nemojte upravljati vozilima niti rukovati alatima i strojevima.
English: Also check it has not passed the expiry date.
Croatian: Osim toga, provjerite da nije istekao rok valjanosti.
English: Hypoglycaemia (in combination with metformin alone)
Croatian: hipoglikemija (u kombinaciji samo s metforminom)
English: • Cold (upper respiratory tract infection)
Croatian: • prehlada (infekcija gornjih dišnih puteva)
English: The results of the primary and secondary composite efficacy endpoints and the results of all the individual components of the composite endpoints are shown in Figure 1.
Croatian: Rezultati primarnog i sekundarnog kompozitnog ishoda djelotvornosti te rezultati svih pojedinih komponenti kompozitnih ishoda prikazani su na slici 1.
English: The injection is administered once daily, within the hour prior to any meal of the day.
Croatian: Injekcija se primjenjuje jedanput na dan, unutar sat vremena prije bilo kojeg dnevnog obroka.
English: EXP Discard pen 14 days after first use
Croatian: EXP Brizgalicu baciti 14 dana nakon prve uporabe
English: Secondary composite endpoints primary + HF primary + HF + Revasc 661 (21.8%) 659 (21.7%) Individual components of composites CV death
Croatian: Primarni + HF + Revasc 661 (21,8%) 659 (21,7%) Pojedinačne komponente kompozitnih ishoda KV smrt
English: • Low blood sugar (when Lyxumia is taken with metformin)
Croatian: • niska razina šećera u krvi (kada se Lyxumia primjenjuje s metforminom)
English: First activate your new pen
Croatian: Prvo aktivirajte novu brizgalicu
English: Do not share it with anyone else.
Croatian: Nemojte je dijeliti ni s jednom drugom osobom.
English: Before activation of the pen:
Croatian: Prije aktivacije brizgalice:
English: • Viral infection
Croatian: • virusna infekcija
English: The needle may be blocked or not properly screwed on.
Croatian: Možda je igla začepljena ili nije dobro navijena na brizgalicu.
English: About your needle (supplied separately)
Croatian: O igli (isporučuje se odvojeno)
English: Overall, 37% of the patients were ≥75 years old (N=131) and 31% had moderate renal impairment (N=107).
Croatian: Sveukupno, 37% bolesnika bilo je u dobi od ≥75 godina (N=131) i 31% bolesnika je imalo umjereno oštećenje bubrega (N=107).
English: Contact your doctor, pharmacist or nurse for advice on checking your blood sugar.
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri za savjet o provjeravanju razine šećera u krvi.
English: Ninety-six percent of the patients in both treatment groups completed the study in accordance with the protocol and the vital status was known at the end of the study for 99.0% and 98.6% of the patients in the lixisenatide and placebo group, respectively.
Croatian: Devedeset i šest posto bolesnika u obje liječene skupine završilo je ispitivanje u skladu s protokolom te je vitalni status na kraju ispitivanja bio poznat za 99,0% bolesnika u skupini s liksisenatidom i 98,6% bolesnika u placebo skupini.
English: • Once activated, store your Lyxumia pen below 30°C.
Croatian: • Nakon aktivacije čuvajte Lyxumia brizgalicu na temperaturi ispod 30°C.
English: What if no liquid comes out during activation?
Croatian: Što ako tijekom aktivacije iz brizgalice ne izađe tekućina?
English: The pen is to be used for one patient only.
Croatian: Brizgalicu smije koristiti samo jedan bolesnik.
English: The most frequent side effects reported with Lyxumia that may affect more than 1 in 10 users (frequency very common) were nausea (feeling sick) and vomiting.
Croatian: Najčešće nuspojave prijavljene s lijekom Lyxumia koje se mogu javiti u više od 1 na 10 osoba (učestalost vrlo često) bile su mučnina i povraćanje.
English: Allergic reactions have been reported in 0.4% of Lyxumia patients.
Croatian: Alergijske reakcije prijavljene su u 0,4% bolesnika liječenih lijekom Lyxumia.
English: The change in HbA1c from baseline was similar regardless of the antibody status (positive or negative).
Croatian: Promjena HbA1c u odnosu na početne vrijednosti bila je slična neovisno o statusu protutijela (pozitivan ili negativan).
English: These reactions were mostly mild and transient.
Croatian: Te su nuspojave uglavnom bile blage i prolazne.
English: Lixisenatide action is mediated via a specific interaction with GLP-1 receptors, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP).
Croatian: Djelovanje liksisenatida je posredovano specifičnom interakcijom s GLP-1 receptorima, koja dovodi do povećanja koncentracije unutarstaničnog cikličkog adenozinfosfata (cAMP).
English: If not, do not use this pen.
Croatian: Ako nije takva, nemojte upotrijebiti brizgalicu.
English: There have been few reported events of acute pancreatitis with lixisenatide although a causal relationship has not been established.
Croatian: Prijavljeno je nekoliko slučajeva akutnog pankreatitisa prilikom primjene liksisenatida iako uzročna veza nije utvrđena.
English: In case of hypoglycaemia, the rescue mechanism of glucagon secretion is preserved.
Croatian: U slučaju hipoglikemije mehanizam spašavanja lučenjem glukagona ostaje očuvan.
English: • Store your unused Lyxumia pens in the refrigerator, 2°C to 8°C.
Croatian: • Čuvajte neupotrijebljene Lyxumia brizgalice u hladnjaku, na temperaturi od 2°C do 8°C.
English: Lixisenatide is a peptide and is not metabolised by cytochrome P450.
Croatian: Liksisenatid je peptid koji se ne metabolizira citokromom P450.
English: Use of glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with a risk of developing acute pancreatitis.
Croatian: Primjena agonista receptora peptida nalik glukagonu-1 (GLP-1) bila je povezana s rizikom od razvoja akutnog pankreatitisa.
English: The incidence of hypoglycaemia was mainly increased in the lixisenatide group during the first 6 weeks of treatment and thereafter, was similar to the placebo group.
Croatian: Incidencija hipoglikemije uglavnom je bila povećana u skupini na liksisenatidu tijekom prvih 6 tjedana liječenja, a nakon toga je bila slična incidenciji u skupini na placebu.
English: • Injection site reactions (such as itching).
Croatian: • reakcije na mjestu injiciranja (kao što je svrbež)
English: Lixisenatide should not be used for treatment of diabetic ketoacidosis.
Croatian: Liksisenatid se ne smije primjenjivati za liječenje dijabetičke ketoacidoze.
English: If it is still hard to press the injection button, your Lyxumia pen may be damaged.
Croatian: Ako je još uvijek teško pritisnuti dugme za injiciranje, možda je Lyxumia brizgalica oštećena.
English: • Do not use Lyxumia after the expiry date which is stated on the label and on the carton.
Croatian: • Lyxumia se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici i kutiji.
English: If you stop using Lyxumia, your blood sugar levels can increase.
Croatian: Ako prestanete primjenjivati lijek Lyxumia, može Vam porasti razina šećera u krvi.
English: The use of Lyxumia does not require specific blood glucose monitoring.
Croatian: Primjena lijeka Lyxumia ne zahtijeva posebno praćenje razine glukoze u krvi.
English: • Only use needles that are approved for use with Lyxumia.
Croatian: • Koristite samo igle koje su odobrene za uporabu s lijekom Lyxumia.
English: After activation of the pen:
Croatian: Nakon aktivacije brizgalice:
English: Sulfonylureas or glinides were not used with basal insulin as background therapy.
Croatian: Sulfonilureje ili glinidi nisu korišteni uz bazalni inzulin kao osnovna terapija.
English: There are no adequate data from the use of Lyxumia in pregnant women.
Croatian: Nema odgovarajućih podataka o primjeni lijeka Lyxumia u trudnica.
English: Your doctor may want to control your blood sugar level and then, decide to reduce your dose of basal insulin or sulphonylurea.
Croatian: Liječnik će Vam možda htjeti provjeriti razinu šećera u krvi i zatim odlučiti smanjiti dozu bazalnog inzulina ili sulfonilureje.
English: In case of overdose, appropriate supportive treatment should be initiated according to the patient's clinical signs and symptoms and the lixisenatide dose should be reduced to the prescribed dose.
Croatian: U slučaju predoziranja mora se uvesti odgovarajuće potporno liječenje prema bolesnikovim kliničkim znakovima i simptomima te smanjiti dozu liksisenatida na propisanu dozu.
English: Treatment Initiation pack - Contains two pre-filled pens each with 14 doses.
Croatian: Pakiranje za početak liječenja - sadrži dvije napunjene brizgalice, a svaka od njih 14 doza.
English: In 2-year subcutaneous carcinogenicity studies, non-lethal C-cell thyroid tumours were seen in rats and mice and are considered to be caused by a non-genotoxic GLP-1 receptor-mediated mechanism to which rodents are particularly sensitive.
Croatian: U 2-godišnjim istraživanjima karcinogenosti nakon supkutane primjene u štakora i miševa primijećeni su nesmrtonosni tumori C-stanica štitnjače za koje se smatra da su uzrokovani negenotoksičnim mehanizmom posredovanim receptorom GLP-1, na koji su glodavci iznimno osjetljivi.
English: Patients receiving medicinal products of either a narrow therapeutic ratio or medicinal products that require careful clinical monitoring should be followed closely, especially at the time of initiation of lixisenatide treatment.
Croatian: Bolesnike koji primaju lijekove koji imaju uzak terapijski indeks ili lijekove koji zahtijevaju pomno kliničko praćenje mora se pažljivo pratiti, osobito u vrijeme započinjanja liječenja liksisenatidom.
English: Neonatal growth was reduced in male rats exposed to high doses of lixisenatide during late gestation and lactation, with a slightly increased pup mortality observed.
Croatian: Neonatalni rast bio je smanjen u mužjaka štakora izloženih visokim dozama liksisenatida tijekom kasne gestacije i laktacije, a opaženo je i blago povećanje smrtnosti mladunčadi.
English: C-cell hyperplasia and adenoma were seen at all doses in rats and a no observed adverse effect level (NOAEL) could be not defined.
Croatian: U štakora su pri svim dozama opaženi hiperplazija C-stanica i adenom, a razina izloženosti pri kojoj nisu opaženi štetni učinci (engl. no observed adverse effect level, NOAEL) nije se mogla utvrditi.
English: The patient should be instructed to discard the needle after each use in accordance with local requirements and to store the pen without the needle attached.
Croatian: Bolesnika treba uputiti da iglu nakon svake primjene zbrine sukladno lokalnim propisima te da brizgalicu čuva bez pričvršćene igle.
English: When Lyxumia is added to existing metformin therapy, the current metformin dose can be continued unchanged.
Croatian: Kada se Lyxumia dodaje postojećoj terapiji metforminom, dotadašnja doza metformina ne mora se mijenjati.
English: As a peptide, lixisenatide is eliminated through glomerular filtration, followed by tubular reabsorption and subsequent metabolic degradation, resulting in smaller peptides and amino acids, which are reintroduced in the protein metabolism.
Croatian: Kao peptid, liksisenatid se eliminira glomerularnom filtracijom, nakon čega slijedi tubularna reapsorpcija i zatim metabolička razgradnja, što rezultira nastankom manjih peptida i aminokiselina, koji ponovno ulaze u metabolizam proteina.
English: The rate of symptomatic hypoglycaemic events was lower with lixisenatide (36%) compared to insulin glulisine QD and TID (47% and 52%, respectively).
Croatian: Stopa simptomatskih hipoglikemijskih događaja bila je niža s liksisenatidom (36%) nego s inzulinom glulizinom QD i TID (47%, odnosno 52%).
English: Excipient(s) with known effects
Croatian: Pomoćna(e) tvar(i) s poznatim učinkom:
English: The pictures below show how the activation window on the injection button of your pen changes after activation.
Croatian: Slike u nastavku pokazuju kako se nakon aktivacije mijenja prozorčić za aktivaciju smješten na dugmetu za injiciranje na brizgalici.
English: • Do not freeze Lyxumia pens and do not use Lyxumia if it has been frozen.
Croatian: • Nemojte zamrzavati Lyxumia brizgalice i nemojte upotrebljavati lijek Lyxumia ako je bio zamrznut.
English: Animal studies did not indicate direct harmful effects with respect to male and female fertility in rats.
Croatian: Istraživanja na životinjama nisu pokazala izravne štetne učinke na plodnost u mužjaka i ženki štakora.
English: • Once your Lyxumia pen is activated it can be used for up to 14 days.
Croatian: • Nakon aktivacije Lyxumia brizgalicu možete upotrebljavati najviše 14 dana.
English: Other side effects include
Croatian: Druge nuspojave uključuju:
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT 3 ml (14 doses)
Croatian: SADRŽAJ PO TEŽINI, VOLUMENU ILI DOZNOJ JEDINICI LIJEKA 3 ml (14 doza)
English: Ask your pharmacist how to throw away the needle you no longer use.
Croatian: Pitajte svog ljekarnika kako baciti iglu koju više ne koristite.
English: Inject only one dose each day.
Croatian: Injicirajte samo jednu dozu svakoga dana.
English: If not, do not use this Treatment Initiation pack.
Croatian: Ako nije takva, nemojte upotrijebiti ovo pakiranje za početak liječenja.
English: A total of 350 patients were randomized (randomization ratio
Croatian: Ukupno 350 bolesnika bilo je randomizirano (omjer randomizacije 1:1).
English: Take care not to injure yourself when the needle is exposed.
Croatian: Pripazite da se ne ozlijedite kada maknete zatvarač s igle.
English: When you are not using the pen, keep the cap on the pen in order to protect from light.
Croatian: Kada brizgalicu ne upotrebljavate, držite zatvarač na brizgalici radi zaštite od svjetlosti.
English: • This pen is only for one person.
Croatian: • Brizgalica je namijenjena samo za jednu osobu.
English: Morning (N= 255)
Croatian: ujutro (N=255)
English: Based on these results, no dose adjustment for paracetamol is required but the delayed tmax observed when paracetamol is administered 1-4 hours after lixisenatide should be taken into account when a rapid onset of action is required for efficacy.
Croatian: Na temelju tih rezultata, nije potrebna prilagodba doze paracetamola, ali se odgođeni tmax primijećen kod primjene paracetamola 1-4 sata nakon liksisenatida mora uzeti u obzir kada je za djelotvornost potreban brz početak djelovanja.
English: Pack containing 1 green pre-filled pen.
Croatian: Pakiranje sadrži 1 zelenu napunjenu brizgalicu.
English: In mice, these effects occurred at exposure ratio above 9.3-fold when compared to human exposure at the therapeutic dose.
Croatian: U miševa su se ti učinci javili kod razine izloženosti više od 9,3 puta veće od one koja se postiže u ljudi nakon primjene terapijske doze.
English: Following administration of a single dose of paracetamol 1,000 mg, paracetamol AUC and t1/2 were unchanged whatever the timing of its administration (before or after the lixisenatide injection).
Croatian: Nakon primjene jednokratne doze paracetamola od 1000 mg AUC i t1/2 paracetamola bili su nepromijenjeni, neovisno o vremenu primjene (prije ili nakon injekcije liksisenatida).
English: Mean HbA1c (±SD) in the lixisenatide and placebo groups was 7.72 (±1.32)% and 7.64 (±1.28)% at baseline and 7.46 (±1.51)% and 7.61 (±1.48)% at 24 months, respectively.
Croatian: Srednje vrijednosti HbA1c (±SD) u skupinama s liksisenatidom i placebom bile su 7,72 (±1,32)% odnosno 7,64 (±1.28)% na početku i 7,46 (±1,51)% odnosno 7,61 (±1,48) nakon 24 mjeseca.
English: • You must activate your Lyxumia pen before you use it for the first time.
Croatian: • Lyxumia brizgalicu morate aktivirati prije prve uporabe.
English: Lixisenatide provided significant improvements in HbA1c (-0.64% change compared to placebo; 95% CI: -0.810% to -0.464%; p<0.0001), from a mean baseline HbA1c of 8.0%.
Croatian: Liksisenatid je doveo do značajnog poboljšanja HbA1c (-0,64% promjene u usporedbi s placebom; 95% IP: -0,810% do -0,464%; p<0,0001) u odnosu na srednje vrijednosti HbA1c od 8,0% na početku.
English: Most of these reported allergic reactions were mild in severity.
Croatian: Većina prijavljenih alergijskih reakcija bila je po težini blaga.
English: • The starting dose is 10 micrograms once a day for the first 14 days - injected using the green pen.
Croatian: • Početna doza je 10 mikrograma jedanput na dan tijekom prvih 14 dana, a injicira se zelenom brizgalicom.
English: In 2-year subcutaneous carcinogenicity study in mice, 3 cases of adenocarcinoma in the endometrium were seen in the mid dose group with a statistically significant increase, corresponding to an exposure ratio of 97-fold.
Croatian: U 2-godišnjem istraživanju karcinogenosti nakon supkutane primjene u miševa u skupini koja je primala srednju dozu opažena su 3 slučaja adenokarcinoma u endometriju, uz statistički značajan porast koji odgovara omjeru izloženosti 97 puta većem od onog u ljudi.
English: Patients received stable dose(s) of oral antidiabetic drug(s) (OAD) and/or basal insulin as background therapy.
Croatian: Bolesnici su primali stalnu dozu (doze) oralnih antidijabetika i/ili bazalni inzulin kao osnovnu terapiju.
English: Add-on combination therapy with oral antidiabetics
Croatian: Dodatak kombiniranoj terapiji oralnim antidijabeticima
English: As lixisenatide is cleared primarily by the kidney, no pharmacokinetic study has been performed in patients with acute or chronic hepatic impairment.
Croatian: Budući da se klirens liksisenatida odvija prvenstveno kroz bubrege, nisu provedena farmakokinetička ispitivanja u bolesnika s akutnim ili kroničnim oštećenjem funkcije jetre.
English: Women of childbearing potential Lyxumia is not recommended in women of childbearing potential not using contraception.
Croatian: Žene reproduktivne dobi Lyxumia se ne preporučuje u žena reproduktivne dobi koje ne primjenjuju kontracepciju.
English: In in vitro studies, lixisenatide did not affect the activity of cytochrome P450 isozymes or human transporters tested.
Croatian: U ispitivanjima in vitro liksisenatid nije utjecao na aktivnost ispitivanih izoenzima citokroma P450 ni humanih transportera.
English: These side effects were mostly mild and usually go away over time.
Croatian: Te su nuspojave uglavnom bile blage i obično se s vremenom povuku.
English: How much to inject
Croatian: Koliko lijeka injicirati