FrancophonIA/ELRC3.0 huggingface dataset:
English: - Take the dose at about the same time each day.
Croatian: - Uzimajte dozu u otprilike isto vrijeme svaki dan.
English: Then take the next tablet at the usual time.
Croatian: Nakon toga uzmite sljedeću tabletu u uobičajeno vrijeme.
English: Complete AV block
Croatian: Potpuni AV blok
English: What to do if you forget to take a tablet depends on how long it is until your next dose.
Croatian: Što trebate učiniti ako ste zaboravili uzeti tabletu ovisi o tome koliko vremena ima do Vaše sljedeće doze.
English: Lorviqua with food and drink
Croatian: Lorviqua s hranom i pićem
English: The clinical study report will be submitted by:
Croatian: Izvješće kliničkog ispitivanja bit će dostavljeno do:
English: Children and adolescents This medicine is only indicated in adults and it is not to be given to children and adolescents.
Croatian: Ovaj lijek se primjenjuje samo u odraslih osoba i ne smije se dati djeci i adolescentima.
English: These symptoms could be signs of heart problems.
Croatian: Ovi simptomi mogu biti znakovi srčanih problema.
English: If you are not able to take the medicine as your doctor has prescribed, or you feel you do not need it anymore, speak with your doctor right away.
Croatian: Ako ne možete uzeti lijek kako je liječnik propisao ili osjećate da ga više ne trebate, odmah razgovarajte sa svojim liječnikom.
English: - You can take the tablets with food or between meals always avoiding grapefruit and grapefruit juice.
Croatian: - Tablete možete uzeti s hranom ili između obroka s tim da uvijek izbjegavate grejpfrut i sok od grejpfruta.
English: You will have blood tests before you start treatment and during your treatment.
Croatian: Obavit ćete krvne pretrage prije početka liječenja i tijekom liječenja.
English: Talk to your doctor about the right methods of contraception for you and your partner.
Croatian: Posavjetujte se sa svojim liječnikom o odgovarajućim metodama kontracepcije za Vas i Vašeg partnera.
English: The effects on male reproductive organs were partially to fully reversible.
Croatian: Učinci na muške reproduktivne organe bili su djelomično do potpuno reverziblni.
English: The safety and efficacy of lorlatinib in paediatric patients below 18 years have not been established.
Croatian: Sigurnost i djelotvornost lorlatiniba u pedijatrijskih bolesnika mlađih od 18 godina nisu ustanovljene.
English: Dosing interruption or dose reduction may be required based on individual safety and tolerability.
Croatian: Privremeni prekid doziranja ili smanjenje doze može biti potrebno ovisno o individualnoj sigurnosti i podnošljivosti.
English: It is important to take Lorviqua every day, for as long as your doctor asks you to.
Croatian: Važno je da uzimate lijek Lorviqua svaki dan dok god liječnik to traži od Vas.
English: Your doctor may investigate further and treat you with other medicines such as antibiotics and steroids.
Croatian: Liječnik će možda provesti dodatne preglede i liječiti Vas drugim lijekovima poput antibiotika i steroida.
English: a Grade categories are based on NCI CTCAE classifications.
Croatian: Kategorije stupnjeva temelje se na NCI CTCAE klasifikacijama.
English: a Alectinib, brigatinib, or ceritinib.
Croatian: Alektinib, brigatinib ili ceritinib.
English: Tell your doctor straight away if you notice any of the following side effects (also section 2 What you need to know before you take Lorviqua).
Croatian: Odmah obavijestite svog liječnika ako primijetite bilo koju od sljedećih nuspojava (pogledajte također dio 2 „Što morate znati prije nego počnete uzimati lijek Lorviqua“).
English: Tests and checks
Croatian: Pretrage i pregledi
English: Atrioventricular block occurred in 1.0% of patients.
Croatian: Atrioventrikularni blok se pojavio u 1,0 % bolesnika.
English: Refer for cardiac observation and monitoring.
Croatian: Uputite na promatranje i praćenje srca.
English: Due to the limited data on this population, no dose recommendation can be made for patients aged 65 years and older (see section 5.2).
Croatian: Zbog ograničenih podataka o ovoj populaciji ne može se dati preporuka za doziranje u bolesnika u dobi od 65 godina i starijih (vidjeti dio 5.2).
English: Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines, including herbal medicines and medicines obtained over the counter.
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući biljne lijekove i bezreceptne lijekove.
English: • If you become pregnant when taking the medicine or during the 5 weeks after taking your last dose, tell your doctor straight away.
Croatian: • Ako zatrudnite dok uzimate lijek ili tijekom 5 tjedana nakon što ste uzeli svoju zadnju dozu, odmah o tome obavijestite svog liječnika.
English: Your doctor may do blood tests to check your liver function.
Croatian: Liječnik će Vas možda poslati na krvne pretrage kako bi provjerio funkciju jetre.
English: Patients should not take 2 doses at the same time to make up for a missed dose.
Croatian: Bolesnici ne smiju uzeti 2 doze istodobno kako bi nadoknadili propuštenu dozu.
English: Studies in animals have shown embryo-foetal toxicity (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su embriofetalnu toksičnost (vidjeti dio 5.3).
English: Greater than or equal to Grade 3: Severe
Croatian: Veće od ili jednake 3. stupnju: teške
English: Patients should be encouraged to take their dose of lorlatinib at approximately the same time each day with or without food (see section 5.2).
Croatian: Bolesnike treba potaknuti da uzimaju svoju dozu lorlatiniba u približno isto vrijeme svaki dan s hranom ili bez nje (vidjeti dio 5.2).
English: You must not take Lorviqua with certain medicines.
Croatian: Ne smijete uzimati lijek Lorviqua s određenim lijekovima.
English: g Speech effects (dysarthria, slow speech, speech disorder).
Croatian: g Učinci na govor (dizartrija, spori govor, poremećaj govora).
English: Other medicines and Lorviqua
Croatian: Drugi lijekovi i Lorviqua
English: These symptoms could be signs of pancreatitis.
Croatian: Ovi simptomi mogu biti znakovi upale gušterače (pankreatitisa).
English: Treatment with lorlatinib is recommended as long as the patient is deriving clinical benefit from therapy without unacceptable toxicity.
Croatian: Liječenje lorlatinibom preporučuje se dok god bolesnik ostvaruje kliničku korist od terapije bez neprihvatljive toksičnosti.
English: Age, gender, race, body weight, and phenotype
Croatian: Dob, spol, rasa, tjelesna težina i fenotip
English: Lorlatinib may be administered with or without food.
Croatian: Lorlatinib se može primijeniti s hranom ili bez hrane.
English: Effective contraception must be continued for at least 35 days after completing therapy.
Croatian: Potrebno je nastaviti s primjenom učinkovite kontracepcije još najmanje 35 dana nakon završetka terapije.
English: If you are not sure, talk to your doctor, pharmacist or nurse before taking Lorviqua.
Croatian: Ako niste sigurni, obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete lijek Lorviqua.
English: You must not drink grapefruit juice or eat grapefruit while on treatment with Lorviqua as they may change the amount of Lorviqua in your body.
Croatian: Ne smijete piti sok od grejpfruta ili jesti grejpfrut za vrijeme liječenja lijekom Lorviqua jer oni mogu promijeniti količinu lijeka Lorviqua u Vašem tijelu.
English: Do not use this medicine if you notice that the package is damaged or shows signs of tampering.
Croatian: Ovaj lijek se ne smije upotrijebiti ako primijetite da je pakiranje oštećeno ili ima znakove neovlaštene uporabe.
English: Atrioventricular block
Croatian: Atrioventrikularni blok
English: The tablets should be swallowed whole (tablets should not be chewed, crushed or split prior to swallowing).
Croatian: Tablete treba progutati cijele (ne smiju se žvakati, lomiti ili dijeliti prije gutanja).
English: Tell your doctor immediately if you develop: - heart problems.
Croatian: Odmah se obratite svom liječniku ako se u Vas pojave sljedeći simptomi: - problemi sa srcem.
English: - Sometimes your doctor may lower your dose, stop your treatment for a short time or stop your treatment completely if you feel unwell.
Croatian: - S vremena na vrijeme liječnik Vam može smanjiti dozu, prekinuti liječenje na kraće vrijeme ili potpuno prekinuti liječenje ako se osjećate loše.
English: Given the dose-dependent effect on PR interval, ECG monitoring is recommended.
Croatian: S obzirom na učinak na PR-interval ovisan o dozi, preporučuje se praćenje EKG-a.
English: This is because it is not known if Lorviqua can pass into breast milk and could therefore harm your baby.
Croatian: To je zato jer nije poznato može li lijek Lorviqua prijeći u majčino mlijeko i na taj način naškoditi Vašem djetetu.
English: The most common adverse reactions that led to dose reductions were oedema and peripheral neuropathy.
Croatian: Najčešće nuspojave koje su dovele do smanjenja doze bile su edem i periferna neuropatija.
English: If a dose of Lorviqua is missed, then it should be taken as soon as the patient remembers unless it is less than 4 hours before the next dose, in which case the patient should not take the missed dose.
Croatian: Ako je doza lijeka Lorviqua propuštena, bolesnik je treba uzeti čim se sjeti, osim u slučaju da je preostalo manje od 4 sata do sljedeće doze jer tada bolesnik ne smije uzeti propuštenu dozu.
English: If you have any questions about how Lorviqua works or why this medicine has been prescribed for you, ask your doctor.
Croatian: Ako imate dodatnih pitanja u vezi s djelovanjem lijeka Lorviqua ili razlogom zašto Vam je ovaj lijek propisan, obratite se liječniku.
English: What Lorviqua contains - The active substance is lorlatinib.
Croatian: Što Lorviqua sadrži - Djelatna tvar je lorlatinib.
English: Treatment with lorlatinib should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.
Croatian: Liječenje lorlatinibom treba započeti i nadzirati liječnik iskusan u primjeni lijekova protiv raka.
English: - cough, chest pain, or a worsening of existing respiratory symptoms.
Croatian: - kašalj, bol u prsnom košu ili pogoršanje postojećih simptoma povezanih s disanjem.
English: Men should seek advice on effective fertility preservation before treatment.
Croatian: Muškarci trebaju prije liječenja potražiti savjet o učinkovitom očuvanju plodnosti.
English: Effective contraception must be continued for at least 35 days after completing therapy (see section 4.6).
Croatian: Potrebno je nastaviti s primjenom učinkovite kontracepcije najmanje 35 dana nakon završetka terapije (vidjeti dio 4.6).
English: • Do not take Lorviqua if you are pregnant.
Croatian: • Ne smijete uzimati lijek Lorviqua ako ste trudni.
English: Monitor ECG/symptoms potentially related to AV block closely.
Croatian: Pomno pratite EKG/simptome potencijalno povezane s AV blokom.
English: Carcinogenicity studies have not been conducted with lorlatinib.
Croatian: Ispitivanja kancerogenosti nisu provedena s lorlatinibom.
English: Grade 4: Life-threatening/Urgent intervention indicated
Croatian: 4. stupanj: opasne po život/indicirana je hitna intervencija
English: If you take more Lorviqua than you should
Croatian: Ako uzmete više lijeka Lorviqua nego što ste trebali
English: You should take special care when driving and using machines when taking Lorviqua because of its effects on your mental state.
Croatian: Trebate biti posebno oprezni pri upravljanju vozilima i radu sa strojevima kada uzimate lijek Lorviqua zbog njegovog učinka na Vaše mentalno stanje.
English: Psychiatric disorders Mood effectsc Hallucinationsd
Croatian: Psihijatrijski poremećaji Učinci na raspoloženje Halucinacije
English: - If your next dose is in 4 hours or more, take the missed tablet as soon as you remember.
Croatian: - Ako trebate uzeti svoju sljedeću dozu za 4 sata ili više, uzmite propuštenu tabletu čim se sjetite.
English: The prolongation of PR interval occurred in a concentration-dependent manner.
Croatian: Produljenje PR intervala pokazalo je ovisnost o koncentraciji.
English: Lorlatinib may reduce the effectiveness of hormonal contraceptive methods (for example, birth control pill); therefore, hormonal contraceptives may not be considered highly effective.
Croatian: Lorlatinib može smanjiti učinkovitost hormonalnih metoda kontracepcije (na primjer kontracepcijske tablete) i zato hormonalna kontracepcijska sredstva možda neće biti visokoučinkovita.
English: Lorlatinib was also capable of penetrating the blood-brain barrier.
Croatian: Lorlatinib je ujedno pokazao sposobnost prolaska kroz krvno-moždanu barijeru.
English: - The other ingredients are:
Croatian: - Pomoćne tvari su:
English: Withhold dose until toxicity is less than or equal to Grade 1.
Croatian: Ne primjenjujte dozu dok toksičnost ne bude niža od ili jednaka 1. stupnju.
English: There is no antidote for lorlatinib.
Croatian: Ne postoji antidot za lorlatinib.
English: If hormonal contraception is unavoidable it must be used in combination with a condom.
Croatian: Ako se hormonalna kontracepcija ne može izbjeći, mora se koristiti u kombinaciji s prezervativom.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke šećere, obratite se svom liječniku prije nego uzmete ovaj lijek.
English: Among the 284 patients with PR interval < 200 msec, 14% had PR interval prolongation ≥ 200 msec after starting lorlatinib.
Croatian: Među 284 bolesnika s PR intervalom < 200 ms, 14% je imalo produljenje PR intervala ≥ 200 ms nakon početka uzimanja lorlatiniba.
English: Pneumonitisi
Croatian: Pneumonitis
English: Consider effects of concomitant medicinal products, and assess and correct electrolyte imbalance that may prolong PR interval.
Croatian: Uzmite u obzir učinke istodobno primijenjenih lijekova te procijenite i korigirajte poremećaj ravnoteže elektrolita koji može produljiti PR-interval.
English: OPA/Al/PVC blisters with aluminium foil backing containing 10 film-coated tablets.
Croatian: Blisteri od OPA/Al/PVC-a s pokrovom od aluminijske folije sadrže 10 filmom obloženih tableta.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/19/1355/001 (120 film-coated tablets) EU/1/19/1355/003 (90 film-coated tablets)
Croatian: EU/1/19/1355/001 (120 filmom obloženih tableta) EU/1/19/1355/003 (90 filmom obloženih tableta)
English: - The recommended dose is one tablet of 100 mg taken by mouth once daily.
Croatian: - Preporučena doza je jedna tableta od 100 mg koja se uzima kroz usta jednom na dan.
English: Dose modification recommendations for toxicities and for patients who develop atrioventricular (AV) block are provided in Table 1.
Croatian: Preporuke za prilagodbu doze zbog toksičnosti i za bolesnike u kojih se razvije atrioventrikularni (AV) blok navedene su u tablici 1.
English: If you vomit after taking a dose of Lorviqua, do not take an extra dose, just take your next dose at the usual time.
Croatian: Ako povraćate nakon uzimanja lijeka Lorviqua Ako povratite nakon uzimanja doze lijeka Lorviqua, nemojte uzeti dodatnu dozu, samo uzmite svoju sljedeću dozu u uobičajeno vrijeme.
English: If a hormonal method of contraception is unavoidable, then a condom must be used in combination with the hormonal method.
Croatian: Ako se ne može izbjeći hormonalna metoda kontracepcije, mora se koristiti prezervativ u kombinaciji s hormonalnom metodom.
English: Contains lactose (see leaflet for further information).
Croatian: Sadrži laktozu (za dodatne informacije vidjeti uputu o lijeku).
English: Do not use this medicine after the expiry date which is stated on the blister foil and carton after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na foliji blistera i kutiji iza oznake „EXP“.
English: Terms actually reported in the studies and contributing to the relevant adverse reaction are indicated in parentheses, as listed below.
Croatian: Nazivi koji su zapravo zabilježeni u ispitivanjima i koji pridonose određenoj nuspojavi navedeni su u zagradama, kao što je prikazano u nastavku.
English: - pain in the back or abdomen (belly), yellowing of the skin and eyes (jaundice), nausea or vomiting.
Croatian: - bol u leđima ili abdomenu (trbuhu), žutilo kože i bjeloočnica (žutica), mučnina ili povraćanje.
English: Risk of pancreatitis should be considered in patients receiving lorlatinib due to concomitant hypertriglyceridemia and/or a potential intrinsic mechanism.
Croatian: Potrebno je uzeti u obzir rizik od pankreatitisa u bolesnika koji primaju lorlatinib zbog istodobne hipertrigliceridemije i/ili potencijalnog intrinzičnog mehanizma.
English: All target organ findings with the exception of hepatic bile duct hyperplasia were partially to fully reversible.
Croatian: Svi nalazi ciljnih organa s iznimkom hiperplazije žučovoda bili su djelomično do potpuno reverzibilni.
English: Monitor electrocardiogram (ECG) prior to initiating lorlatinib and monthly thereafter, particularly in patients with predisposing conditions to the occurrence of clinically significant cardiac events.
Croatian: Pratite EKG prije početka liječenja lorlatinibom i mjesečno nakon toga, osobito u bolesnika sklonih stanjima koja dovode do pojave klinički značajnih srčanih događaja.
English: Do not take Lorviqua - if you are allergic to lorlatinib or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati lijek Lorviqua - ako ste alergični na lorlatinib ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.) - ako uzimate neki od sljedećih lijekova:
English: These tests are to check the level of cholesterol, triglycerides and the enzymes amylase or lipase in your blood before you start treatment with Lorviqua and regularly during treatment.
Croatian: Te pretrage trebaju provjeriti razine kolesterola, triglicerida i enzima amilaze ili lipaze u krvi prije početka liječenja lijekom Lorviqua i redovito tijekom liječenja.
English: Lorlatinib has moderate influence on the ability to drive and use machines.
Croatian: Lorlatinib umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: 30 June 2024
Croatian: 30. lipnja
English: The primary efficacy endpoint in the Phase 2 portion of the study was objective response rate (ORR), including intracranial (IC)-ORR, as per Independent Central Review (ICR) according to modified response evaluation criteria in solid tumours (modified RECIST version 1.1).
Croatian: Primarna mjera ishoda djelotvornosti u dijelu ispitivanja faze 2 bila je stopa objektivnog odgovora, uključujući intrakranijalnu (IK) stopu objektivnog odgovora, prema neovisnoj središnjoj procjeni u skladu s modificiranim Kriterijima procjene odgovora kod čvrstih tumora (modificirani RECIST, verzija 1.1).
English: Do not breast-feed while taking this medicine and for 7 days after the last dose.
Croatian: - Dojenje Ne smijete dojiti dok uzimate ovaj lijek i tijekom 7 dana nakon zadnje doze.
English: What Lorviqua is and what it is used for 2.
Croatian: Što je Lorviqua i za što se koristi 2.
English: Hypersensitivity to lorlatinib or to any of the excipients listed in section 6.1.
Croatian: Preosjetljivost na lorlatinib ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: This medicinal product contains lactose as an excipient.
Croatian: Ovaj lijek sadrži laktozu kao pomoćnu tvar.
English: Two of these ALK mutants, G1202R and I1171T, are known to confer resistance to alectinib, brigatinib, ceritinib, and crizotinib.
Croatian: Za dvije od navedenih mutacija ALK-a, G1202R i I1171T, poznato je da omogućuju rezistenciju na alektinib, brigatinib, ceritinib i krizotinib.
English: In vitro studies also indicated that lorlatinib is an inducer of CYP2B6 and activates the human constitutive androstane receptor (CAR).
Croatian: In vitro ispitivanja pokazala su i da je lorlatinib induktor CYP2B6 i aktivira ljudski konstitutivni receptor za androstan (CAR).
English: - Swallow the tablets whole and do not crush, chew or dissolve the tablets.
Croatian: - Progutajte tablete cijele i nemojte ih lomiti, žvakati ili rastopiti.
English: In vitro studies with drug transporters
Croatian: In vitro ispitivanja s prijenosnicima lijekova
English: Lorlatinib is not recommended during pregnancy or for women of childbearing potential not using contraception.
Croatian: Ne preporučuje se koristiti lorlatinib tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju.
English: Interstitial lung disease/Pneumonitis
Croatian: Intersticijska plućna bolest/pneumonitis
English: This is because Lorviqua can affect the way some other medicines work.
Croatian: To je potrebno jer Lorviqua može utjecati na način djelovanja nekih lijekova.
English: The oxidative cleavage metabolite is pharmacologically inactive.
Croatian: Metabolit oksidativnog cijepanja farmakološki je neaktivan.
English: Breast-feeding should be discontinued during treatment with lorlatinib and for 7 days after the final dose.
Croatian: Dojenje treba prekinuti za vrijeme liječenja lorlatinibom i tijekom 7 dana nakon posljednje doze.
English: See Lorviqua contains lactose and Lorviqua contains sodium in section 2.
Croatian: Vidjeti „Lorviqua sadrži laktozu“ i „Lorviqua sadrži natrij“ u dijelu 2.
English: Fertility and pregnancy
Croatian: Plodnost i trudnoća
English: Also some medicines can affect the way Lorviqua works.
Croatian: Ujedno neki lijekovi mogu utjecati na način djelovanja lijeka Lorviqua.
English: Talk to your doctor about fertility preservation before taking Lorviqua.
Croatian: Posavjetujte se sa svojim liječnikom o očuvanju plodnosti prije nego što uzmete lijek Lorviqua.
English: In vitro binding of lorlatinib to human plasma proteins is 66% with moderate binding to albumin or to α1-acid glycoprotein.
Croatian: In vitro vezanje lorlatiniba na proteine ljudske plazme iznosi 66 % s umjerenim vezanjem na albumin ili na α1-kiseli glikoprotein.
English: Also, at steady-state lorlatinib plasma exposures are lower than those expected from single dose pharmacokinetics, indicative of a net time-dependent auto-induction effect.
Croatian: Isto tako, izloženosti lorlatinibu u plazmi u stanju dinamičke ravnoteže niže su od onih očekivanih kod farmakokinetike pojedinačne doze, što ukazuje na neto učinak autoindukcije ovisne o vremenu.
English: Central nervous system effects (changes in cognition, mood or speech) Grade 2: Moderate
Croatian: Učinci na središnji živčani sustav (promjene u kognitivnim funkcijama, raspoloženju ili govoru) 2. stupanj: umjereni
English: If you are able to have children, you must use highly effective contraception (for example, double-barrier contraception such as condom and diaphragm) while on treatment and for at least 5 weeks after stopping treatment.
Croatian: Ako možete imati djecu, morate koristiti visokoučinkovitu kontracepciju (na primjer kontracepciju dvostrukom barijerom kao što je kombinacija prezervativa i dijafragme) tijekom trajanja liječenja i najmanje 5 tjedana nakon prekida liječenja.
English: Brain metastases were present at baseline in 67% of patients.
Croatian: Na početku ispitivanja metastaze u mozgu bile su prisutne u 67 % bolesnika.
English: United Kingdom Pfizer Limited Tel: +44 (0) 1304 616161
Croatian: Ujedinjeno Kraljevstvo Pfizer Limited Tel: +44 (0) 1304 616161
English: Unchanged lorlatinib was the major component of human plasma and faeces, accounting for 44% and 9.1% of total radioactivity, respectively.
Croatian: Nepromijenjeni lorlatinib bio je glavna komponenta u ljudskoj plazmi i stolici, te je činio 44 % odnosno 9,1 % ukupne radioaktivnosti.
English: At steady-state, the systemic exposure (AUC24 and Cmax) increased less than proportionally over the 10 to 200 mg dose range.
Croatian: U stanju dinamičke ravnoteže sustavna izloženost (AUC24 i Cmax) povećavala se manje nego proporcionalno u rasponu doze od 10 do 200 mg.
English: Treatment of overdose with the medicinal product consists of general supportive measures.
Croatian: Liječenje predoziranja sastoji se od općih potpornih mjera.