FrancophonIA/ELRC3.0 huggingface dataset:
English: The randomised phase III first line IPASS study was conducted in patients in Asia1 with advanced (stage IIIB or IV) NSCLC of adenocarcinoma histology who were ex-light smokers (ceased smoking ≥ 15 years ago and smoked ≤ 10 pack years) or never smokers (see Table 3).
Danish: Det randomiserede fase III-førstelinjeforsøg IPASS blev gennemført med patienter fra Asien1, som havde avanceret NSCLC (i stadie IIIB eller IV) med adenocarcinom-histologi og var tidligere lette rygere (rygeophør ≥ 15 år siden og cigaretforbrug ≤ 10 pakkeår), eller som aldrig havde røget (se tabel 3).
English: This medicinal product contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free'.
Danish: Dette lægemiddel indeholder mindre end 1 mmol natrium (23 mg) pr. tablet, dvs. den er i det væsentlige natriumfri.
English: • Protein in your urine (shown in a urine test).
Danish: • Protein i urinen (ses ved en urintest).
English: Elevations in total bilirubin, mainly mild to moderate.
Danish: Forøgelse af total bilirubin, hovedsagligt let til moderat.
English: FACT-L Functional assessment of cancer therapy-lung.
Danish: QoL Livskvalitet (Quality of life) FACT L Functional assessment of cancer therapy-lung.
English: Gefitinib binds to serum albumin and alpha 1-acid glycoprotein.
Danish: Gefitinib bindes til serumalbumin og surt -1-glykoprotein.
English: a Values presented are for gefitinib versus docetaxel.
Danish: a Værdierne er for gefitinib versus docetaxel.
English: Data from non-clinical (in vitro) studies indicate that gefitinib has the potential to inhibit the cardiac action potential repolarization process (e.g. QT interval).
Danish: Data fra prækliniske (in vitro) forsøg indikerer, at gefitinib potentielt kan hæmme den kardielle aktionspotentiale-repolariseringsproces (fx QT-interval).
English: smoking, CT scan evidence of reduced normal lung (≤ 50%), pre-existing ILD, older age (≥ 65 years old), and extensive areas adherent to pleura (≥ 50%).
Danish: Rygning, reduceret normalt lungevæv (≤ 50 %) dokumenteret ved CT-scanning, tidligere ILS, ældre patienter (≥ 65 år gammel) og udtalte områder med pleural adhærence (≥ 50 %).
English: 40/235 (17%) of females are M+.
Danish: 40/235 (17 %) af kvinderne er M+ 35/551 (6 %) af mændene er M+..
English: Adverse reactions by system organ class and frequency Metabolism and nutrition disorders
Danish: Tabel 1 - Bivirkninger Bivirkninger efter organklasse og hyppighed Metaboliske og ernæringsmæssige lidelser
English: • Nail problems.
Danish: • Negleproblemer.
English: Gefitinib Mylan contains the active substance gefitinib which blocks a protein called ‘epidermal growth factor receptor' (EGFR).
Danish: Gefitinib blokerer et protein, der kaldes EGFR (epidermal vækstfaktorreceptor).
English: Conjunctivitis, blepharitis, and dry eye*, mainly mild (CTC grade 1).
Danish: Konjunktivitis, blefaritis og tørt øje*, primært mild (CTC-grad 1).
English: Interstitial lung disease (ILD) has occurred in 1.3% of patients, often severe (CTC grade 3-4).
Danish: Interstitiel lungesygdom (ILS) er forekommet hos 1,3 % af patienterne, ofte i alvorlig grad (CTC grad 3 - 4).
English: • Weakness.
Danish: • Svaghed.
English: Interstitial lung disease (1.3%), often severe (CTC grade 3-4).
Danish: Interstitiel lungesygdom (1,3 %), ofte svær (CTCgrad 3 4).
English: HR Hazard ratio (hazard ratios <1 favour gefitinib).
Danish: HR Hazard ratio (hazard ratio <1 favoriserer gefitinib).
English: In the IPASS trial, gefitinib demonstrated superior PFS, ORR, QoL and symptom relief with no significant difference in overall survival compared to carboplatin/paclitaxel in previously untreated patients, with locally advanced or metastatic NSCLC, whose tumours harboured activating mutations of the EGFR tyrosine kinase.
Danish: IPASS-forsøget viste, at gefitinib var carboplatin/paclitaxel overlegen i forhold til PFS, ORR, QoL og mht. symptomlindring, uden at der var nogen signifikant forskel på den samlede overlevelse hos behandlingsnaive patienter med lokalt fremskredent eller metastatisk NSCLC, hvis tumorer indeholdt aktiverende mutationer af EGFR-tyrosinkinase.
English: a Values presented are for gefitinib versus placebo.
Danish: Værdier for gefitinib versus placebo.
English: Medicinal products that cause significant sustained elevation in gastric pH, such as proton-pump inhibitors and h2-antagonists may reduce bioavailability and plasma concentrations of gefitinib and, therefore, may reduce efficacy.
Danish: Lægemidler, som forårsager vedvarende forhøjet gastrisk pH, såsom protonpumpehæmmere og h2antagonister kan reducere biotilgængeligheden og plasmakoncentrationen af gefitinib, og kan derfor reducere effekten.
English: At steady state, circulating plasma concentrations are typically maintained within a 2- to 3-fold range over the 24-hour dosing interval.
Danish: Ved steady state er den cirkulerende plasmakoncentration fastholdt, så Cmax typisk er 2 til 3 gange højere end Cmin inden for doseringsintervallet på 24 timer.
English: The recommended posology of Gefitinib Mylan is one 250 mg tablet once a day.
Danish: Den anbefalede dosering af Gefitinib Mylan er én tablet a 250 mg én gang dagligt.
English: HR Hazard ratio (hazard ratios <1 favour gefitinib)
Danish: HR Hazard ratio (hazard ratio <1 favoriserer gefitinib)
English: PVC/PVDC/Aluminium blister in cartons containing 30 film-coated tablets.
Danish: Blisterpakninger i PVC/PVDC/Aluminium i kartoner indeholdende 30 filmovertrukne tabletter.
English: Gefitinib Mylan is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating mutations of EGFR-TK (see section 4.4).
Danish: Gefitinib Mylan som monoterapi er indiceret til behandling af voksne patienter med lokalt avanceret eller metastatisk ikke-småcellet lungecancer (NSCLC) med aktiverede EGFR-TK-mutationer (se pkt.
English: 1.7 times higher in females than males
Danish: 0,0397 1,7 gange højere hos kvinder end hos mænd
English: Concomitant medicinal products that induce CYP3A4 (e.g. phenytoin, carbamazepine, rifampicin, barbiturates or St John's wort, Hypericum perforatum) should be avoided.
Danish: Samtidig behandling med lægemidler, der inducerer CYP3A4 (fx phenytoin, carbamazepin, rifampicin, barbiturater eller perikon, hypericum perforatum), bør undgås.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 250 mg of gefitinib.
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING Hver filmovertrukken tablet indeholder 250 mg gefitinib.
English: Liver function test abnormalities (including increases in alanine aminotransferase, aspartate aminotransferase, bilirubin) have been observed, uncommonly presenting as hepatitis (see section 4.8).
Danish: Unormale værdier ved leverfunktionsundersøgelser (inklusive øget alaninaminotransferase, aspartataminotransferase, bilirubin) blev observeret og blev registreret som hepatitis med frekvensen ”ikke almindelig” (se pkt.
English: What Gefitinib Mylan looks like and contents of the pack Gefitinib Mylan tablets are brown, round, biconvex film-coated tablets with approximately 11.1 mm x 5.6 mm of dimension and marked with “250” on one side and plain on the other.
Danish: Gefitinib Mylan er en rund, brun, bikonveks, filmovertrukket tablet med dimensionerne ca. 11,1 mm × 5,6 mm og mærket med “250” på den ene side og uden mærkning på den anden.
English: N HR
Danish: for HR
English: Active substances that may have their plasma concentrations altered by gefitinib In vitro studies have shown that gefitinib has limited potential to inhibit CYP2D6.
Danish: Aktive substanser, hvis plasmakoncentration kan ændres gefitinib In vitro-studier har vist, at gefitinib har begrænset potentiale for at hæmme CYP2D6.
English: - If you get any side effects, talk to your doctor, pharmacist or nurse.
Danish: - Hvis du oplever bivirkninger, bør du tale med din læge, sygeplejerske eller apoteket.
English: INFORMATION IN BRAILLE gefitinib mylan 250 mg
Danish: INFORMATION I BRAILLESKRIFT gefitinib mylan 250 mg
English: If you take more Gefitinib Mylan than you should If you have taken more tablets than you should, talk to a doctor or pharmacist straight away.
Danish: Hvis du har taget for mange Gefitinib Mylan tabletter Kontakt din læge eller apoteket straks, hvis du har taget flere tabletter end du må.
English: Overall survivala,b
Danish: Total overlevelsea,b
English: Very common Elevations in alanine aminotransferase, mainly mild to moderate.
Danish: Forøgelse af alaninaminotransferase, hovedsageligt let til moderat.
English: Elevations in aspartate aminotransferase, mainly mild to moderate.
Danish: Forøgelse af aspartataminotransferase, hovedsageligt let til moderat.
English: • Dehydration (common) caused by long term or severe diarrhoea, vomiting (being sick), nausea (feeling sick) or loss of appetite.
Danish: • Dehydrering (almindelig) som følge af længerevarende diarré, opkastning, kvalme eller appetitløshed.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS PERFORATED UNIT DOSE BLISTER
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP PERFOREREDE ENKELTDOSISBLISTERPAKNINGER
English: Therefore, concomitant administration of CYP3A4 inducers (e.g. phenytoin, carbamazepine, rifampicin, barbiturates or herbal preparations containing St John's wort/Hypericum perforatum) may reduce efficacy of the treatment and should be avoided (see section 4.5).
Danish: Derfor kan samtidig administration af CYP3A4-inducere (fx phenytoin, carbamazepin, rifampicin, barbiturater eller planteformuleringer indeholdende perikon/hypericum perforatum) reducere behandlingseffekten og bør derfor undgås (se pkt.
English: What Gefitinib Mylan contains - The active substance is gefitinib.
Danish: Gefitinib Mylan indeholder - Aktivt stof: gefitinib.
English: Each film-coated tablet contains 250 mg of gefitinib.
Danish: Hver filmovertrukken tablet indeholder 250 mg gefitinib.
English: It comes in PVC/PVDC/Aluminium blisters in packs of 30 film-coated tablets or in PVC/PVDC/Aluminium perforated unit dose blisters in packs of 30x1 film-coated tablets.
Danish: Den findes i blisterpakninger i PVC/PVDC/Aluminium med 30 filmovertrukne tabletter eller i perforerede enkeltdosisblisterpakninger i PVC/PVDC/Aluminium med 30×1 filmovertrukne tabletter.
English: EGFR mutation-unknown
Danish: EGFRmutation ukendt
English: Numbers in square brackets are 95%confidence intervals for HR. c Stratified log-rank test for overall; otherwise cox proportional hazards model.
Danish: Stratificeret log-rank test for samlede resultater ellers er Cox Proportional Hazard Model anvendt.
English: Progression free survivala,b
Danish: Progressionsfri overlevelsea,b
English: What you need to know before you take Gefitinib Mylan
Danish: Det skal du vide, før du begynder at tage Gefitinib Mylan
English: Primary endpoint overall survivala,b,c
Danish: Primært endepunkt total overlevelsea,b,c
English: Table 5 - Efficacy outcomes for gefitinib versus docetaxel from the INTEREST study Population
Danish: Tabel 5 - Data for virkning af gefitinib versus docetaxel fra INTEREST-studiet Population
English: Values presented are for gefitinib versus carboplatin/paclitaxel.
Danish: Værdier for gefitinib versus carboplatin/paclitaxel.
English: Table 4 - Quality of life outcomes for gefitinib versus carboplatin/paclitaxel from the IPASS study
Danish: Tabel 4 - Resultatet for livskvalitet for gefitinib versus carboplatin/paclitaxel fra IPASS-studiet Population
English: Renal and urinary disorders Common
Danish: Lidelser i nyrer og urinveje Almindelig
English: Very common (may affect more than 1 in 10 people):
Danish: Meget almindeligt (kan påvirke mere end 1 ud af 10 patienter):
English: Numbers in square brackets are 95% confidence intervals for HR Number of patients randomised.
Danish: Tal i de kvadratiske parenteser er 95 % konfidensinterval (CI) for HR.
English: 117 Allée des Parcs 69800 Saint-Priest
Danish: 69800 Saint Priest
English: Gefitinib Mylan contains lactose
Danish: Gefitinib Mylan indeholder lactose
English: • Inflammation of the blood vessels in the skin.
Danish: • Betændelse (inflammation) i hudens blodkar.
English: Table 6 Efficacy outcomes for gefitinib versus placebo from the ISEL study Population
Danish: Tabel 6 Data for virkning af gefitinib versus placebo fra ISEL-studiet Population
English: Table 3 - Efficacy outcomes for gefitinib versus carboplatin/paclitaxel from the IPASS study Population
Danish: Tabel 3 - Virkningen af gefitinib versus carboplatin/paclitaxel fra IPASS-studiet Population
English: • If it is less than 12 hours until your next dose: skip the missed tablet.
Danish: • Hvis der er mindre end 12 timer til din næste dosis: Spring den glemte tablet over, og tag den næste tablet på samme tid, som du plejer.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 250 mg of gefitinib.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver filmovertrukken tablet indeholder 250 mg gefitinib.
English: PVC/PVDC/Aluminium perforated unit dose blister in cartons containing 30x1 film-coated tablets.
Danish: Perforerede enkeltdosisblisterpakninger i PVC/PVDC/Aluminium i kartoner indeholdende 30×1 filmovertrukne tabletter.
English: Gefitinib Mylan contains lactose.
Danish: Gefitinib Mylan indeholder lactose.
English: Ever smoker
Danish: Personer som har røget på et eller andet tidspunkt
English: In a phase III open-label clinical trial (IPASS) in 1217 patients comparing gefitinib to carboplatin/paclitaxel doublet chemotherapy as first-line treatment in selected patients with advanced NSCLC in Asia, the incidence of ILD-type events was 2.6% on the gefitinib treatment arm versus 1.4% on the carboplatin/paclitaxel treatment arm.
Danish: I et åbent, klinisk fase III-forsøg (IPASS) med 1.217 patienter, blev gefitinib sammenlignet med kemoterapi med to lægemidler, carboplatin og paclitaxel, som førstelinjebehandling hos udvalgte patienter med avanceret NSCLC i Asien.
English: First line treatment
Danish: Førstelinjebehandling
English: Primary endpoint overall survivala,b
Danish: Primært endepunkt total overlevelsea,b
English: Asiansd
Danish: Asiatered
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Danish: Spørg din læge eller apoteket til råds, før du tager denne medicin, hvis du er gravid, har chance for at blive gravid, eller hvis du ammer.
English: Very common Diarrhoea, mainly mild or moderate (CTC grade 1 or 2).
Danish: Diarré, hovedsageligt let eller moderat (CTC-grad 1 eller 2).
English: Very common Anorexia mild or moderate (CTC grade 1 or 2).
Danish: Anoreksi, let eller moderat (CTC-grad 1 eller 2).
English: Gefitinib Mylan 250 mg film-coated tablets gefitinib
Danish: Gefitinib Mylan 250 mg filmovertrukne tabletter gefitinib
English: Vomiting, mainly mild or moderate (CTC grade 1 or 2).
Danish: Opkastning, hovedsageligt let eller moderat (CTCgrad 1 eller 2).
English: How to take Gefitinib Mylan
Danish: Sådan skal du tage Gefitinib Mylan
English: How to store Gefitinib Mylan
Danish: Opbevaring af Gefitinib Mylan
English: Haemorrhage, such as epistaxis and haematuria.
Danish: Blødning, såsom epistaxis og hæmaturi
English: Uncommon (may affect up to 1 in 100 people):
Danish: Ikke almindeligt (kan forekomme hos op til 1 ud af 100 personer):
English: In particular, tell your doctor or pharmacist if you are taking any of the following medicines: - Phenytoin or carbamazepine (for epilepsy).
Danish: Hvis du tager nogen af disse lægemidler, skal du især huske at fortælle det til din læge eller på apoteket: - Phenytoin eller carbamazepin (mod epilepsi) - Rifampicin (mod tuberkulose) - Itraconazol (mod svampeinfektion) - Barbiturater (en type af medicin, der bruges mod søvnproblemer) - Naturlægemidler, som indeholder perikon (Hypericum Perforatum, mod depression og angst)
English: HR 1.04 2.2 m vs 2.7 m p=0.4658
Danish: 2,2 m vs. 2,7 m p=0,4658
English: • Inflammation of the liver.
Danish: • Betændelse (inflammation) i leveren.
English: Asiansc
Danish: Asiaterec
English: Primary endpoint Progression free survival (PFS) a,b
Danish: Primært endepunkt Progressionsfri overlevelsea,b
English: NAME OF THE MEDICINAL PRODUCT Gefitinib Mylan 250 mg tablets gefitinib
Danish: LÆGEMIDLETS NAVN Gefitinib Mylan 250 mg tabletter gefitinib
English: Dry mouth*, predominantly mild (CTC grade 1).
Danish: Tør mund*, hovedsageligt let (CTC-grad 1).
English: • Red and sore eyelids.
Danish: • Røde og ømme øjenlåg.
English: Nausea, mainly mild (CTC grade 1).
Danish: Kvalme, hovedsageligt let (CTC-grad 1).
English: • Vomiting.
Danish: • Opkastning.
English: • Inflammation of the pancreas.
Danish: • Betændelse (inflammation) i bugspytkirtlen.
English: Gefitinib Mylan contains sodium
Danish: Gefitinib Mylan indeholder natrium
English: Vascular disorders
Danish: Magnesiumstearat
English: • Cystitis (burning sensations during urination and frequent, urgent need to urinate).
Danish: • Blærebetændelse (hyppig, sviende vandladning og pludselig vandladningstrang).
English: HR 0.82 [0.70 to 0.96] 18.9 m vs. 17.2 m a b
Danish: HR 0,82 [0,70 til 0,96] 18,9 m vs. 17,2 m a Værdier for gefitinib versus carboplatin/paclitaxel.
English: Stomatitis, predominantly mild in nature (CTC grade 1).
Danish: Stomatit, overvejende let (CTC-grad 1).
English: NAME OF THE MEDICINAL PRODUCT Gefitinib Mylan 250 mg film-coated tablets
Danish: LÆGEMIDLETS NAVN Gefitinib Mylan 250 mg filmovertrukne tabletter
English: Population
Danish: Administration
English: In this study gefitinib exposure did not increase with increasing dose, adverse events were mostly mild to moderate in severity, and were consistent with the known safety profile of gefitinib.
Danish: I et forsøg blev et begrænset antal patienter behandlet ugentligt med doser fra 1.500 mg til 3.500 mg. I dette forsøg øgedes gefitinib-eksponeringen ikke med større doser, og bivirkningerne var for det meste lette til moderate i sværhedsgrad og i overensstemmelse med gefitinibs sikkerhedsprofil.
English: NAME OF THE MEDICINAL PRODUCT Gefitinib Mylan 250 mg film-coated tablets gefitinib
Danish: LÆGEMIDLETS NAVN Gefitinib Mylan 250 mg filmovertrukne tabletter gefitinib
English: QoL
Danish: Køn
English: Gastrointestinal disorders
Danish: Gastrointestinale lidelser Meget almindelig
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Danish: Brug af anden medicin sammen med Gefitinib Mylan Fortæl altid lægen eller apotekspersonalet, hvis du bruger anden medicin eller har gjort det for nylig.
English: Nail disorder
Danish: Nedsat nyrefunktion
English: Lactose monohydrate Microcrystalline cellulose (101) Crospovidone (Type A) Povidone (K30) Sodium laurilsulfate Magnesium stearate
Danish: Cellulose, mikrokrystallinsk (101)
English: Posology
Danish: Neglelidelser
English: • Haemorrhagic cystitis (burning sensations during urination and frequent, urgent need to urinate with blood in the urine).
Danish: • Hæmoragisk blærebetændelse (blærebetændelse med blod i urinen).
English: What you need to know before you take Gefitinib Mylan 3.
Danish: Oversigt over indlægssedlen Gefitinib Mylans virkning og anvendelse Det skal du vide, før du begynder at tage Gefitinib Mylan Sådan skal du tage Gefitinib Mylan Bivirkninger
English: It was to be available as 300 mg tablets.
Danish: Det var hensigten, at det skulle leveres som 300 mg tabletter.
English: Corluxin was not compared with any other medicine.
Danish: Corluxin blev ikke sammenlignet med noget andet lægemiddel.
English: In its letter notifying the Agency of the withdrawal of application, the company stated that the withdrawal was due to strategic business reasons.
Danish: I sit brev til agenturet om tilbagetrækningen af ansøgningen anførte virksomheden, at tilbagetrækningen skyldtes strategiske forretningsmæssige årsager.
English: What is Corluxin?
Danish: Hvad er Corluxin?
English: EMA/261739/2015 EMEA/H/C/002830
Danish: 21. maj 2015 EMA/386100/2015 EMEA/H/C/002830
English: The application was withdrawn after the CHMP had evaluated the documentation provided by the company and formulated lists of questions.
Danish: Ansøgningen blev trukket tilbage, efter at CHMP havde vurderet den dokumentation, virksomheden havde indsendt, og udarbejdet en liste med spørgsmål.
English: Corluxin is a medicine containing the active substance mifepristone.
Danish: Corluxin er et lægemiddel, der indeholder det aktive stof mifepriston.
English: On 23 March 2015, FGK Representative Service GmbH officially notified the Committee for Medicinal Products for Human Use (CHMP) that it wishes to withdraw its application for a marketing authorisation for Corluxin, intended for the treatment of Cushing's syndrome.
Danish: Den 23. marts 2015 meddelte FGK Representative Service GmbH officielt Udvalget for Lægemidler til Mennesker (CHMP), at virksomheden ønsker at trække sin ansøgning tilbage om markedsføringstilladelse for Corluxin til behandling af Cushings syndrom.
English: Withdrawal of the marketing authorisation application for Corluxin (mifepristone)
Danish: Tilbagetrækning af ansøgningen om markedsføringstilladelse for Corluxin (mifepriston)
English: The applicant submitted data from a main study involving 50 patients with Cushing's syndrome who had diabetes and/or high blood pressure, two common features of the condition.
Danish: Ansøgeren fremlagde data fra en hovedundersøgelse med 50 patienter med Cushings syndrom, som havde sukkersyge og/eller højt blodtryk, der er to almindelige kendetegn ved sygdommen.
English: What was Corluxin expected to be used for?
Danish: Hvad forventedes Corluxin anvendt til?
English: The study looked at improvements in blood sugar levels and blood pressure following 24 weeks of Corluxin treatment.
Danish: I undersøgelsen blev blodsukkeret og blodtrykket registreret efter 24-ugers behandling med Corluxin.
English: The CHMP had concerns related to the manufacture of the medicine, including the control of impurities and the testing of the finished product.
Danish: CHMP havde betænkeligheder vedrørende lægemidlets fremstilling, herunder kontrol med urenheder og testning af det færdige præparat.
English: By blocking these receptors, mifepristone is expected to reduce the effects of the excess cortisol circulating in the body, thereby alleviating the symptoms of the disease.
Danish: Ved at blokere disse receptorer forventes mifepriston at mindske virkningerne af forhøjet indhold af kortisol i kroppen og derved at lette sygdomssymptomerne.
English: The CHMP also had concerns about the main study, citing, among other things, the lack of a comparator medicine.
Danish: CHMP havde desuden betænkeligheder ved hovedundersøgelsen og henviste blandt andet til, at der ikke var anvendt et sammenligningslægemiddel.
English: How is Corluxin expected to work?
Danish: Hvordan forventes Corluxin at virke?
English: Patients with Cushing's syndrome can have ‘central' weight gain (affecting the face and torso but not the limbs), growth of fat above the collar bone and the back of the neck, a roundish face, easy bruising, excessive growth of coarse hair on the face, weakening of the muscles and bones, depression, diabetes and high blood pressure.
Danish: Patienter med Cushings syndrom kan få vægtøgning, der omfatter ansigtet og kroppen, men ikke lemmerne ("central" vægtøgning), øget fedtlag over kravebenet og nakken, afrundet ansigtsform, tendens til blå mærker, stærk behåring i ansigtet, svækkelse af muskler og knogler, depression, sukkersyge og forhøjet blodtryk.
English: Cushing's syndrome is a disease characterised by an excess production of the hormone cortisol by the adrenal glands, two glands situated above the kidneys.
Danish: Cushings syndrom er en sygdom, der kendetegnes af for stor produktion af hormonet kortisol fra binyrerne, som er to kirtler, der ligger over nyerne.
English: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom21 May 2015
Danish: 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555