FrancophonIA/ELRC3.0 huggingface dataset:
English: Data from clinical studies in paediatric patients indicate that the safety and efficacy of filgrastim are similar in both adults and children receiving cytotoxic chemotherapy.
Croatian: Podaci iz kliničkih ispitivanja u pedijatrijskih bolesnika pokazuju da su sigurnost i djelotvornost primjene filgrastima u odraslih i djece na citotoksičnoj kemoterapiji slične.
English: It could be a consequence of a pulmonary disorder (see section “4.
Croatian: Ti simptomi bi mogli biti posljedica plućnog poremećaja (vidjeti dio „4. Moguće nuspojave“).
English: Biograstim and neutropenia in patients with HIV infection The usual starting dose is between 0.1 and 0.4 million international units (MIU) per kilogram bodyweight each day.
Croatian: Biograstim i neutropenija u bolesnika s HIV-infekcijom Uobičajena početna doza je između 0,1 milijun i 0,4 milijuna internacionalnih jedinica [MIU] po kilogramu tjelesne težine na dan.
English: When diluted in glucose 50 mg/mL (5 %) solution for infusion, Biograstim is compatible with glass and a variety of plastics including PVC, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Croatian: Kada se razrjeđuje u 5 %-tnoj otopini glukoze (50 mg/ml), Biograstim je kompatibilan sa staklom i različitim vrstama plastike, uključujući PVC, poliolefin (kopolimer polipropilena i polietilena) i polipropilen.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before using this medicine.
Croatian: Ako Vam je liječnik rekao da bolujete od tzv. nepodnošenja nekih šećera, prije nego što počnete uzimati ovaj lijek posavjetujte se sa svojim liječnikom.
English: The long-term safety of filgrastim administration above 2.4 MIU (24 μg)/kg/day in patients with SCN has not been established.
Croatian: Dugoročna sigurnost primjene doza većih od 2,4 MIU (24 μg)/kg/dan u bolesnika s teškom kroničnom neutropenijom nije provjerena.
English: The onset of pulmonary signs such as cough, fever and dyspnoea in association with radiological signs of pulmonary infiltrates and deterioration in pulmonary function may be preliminary signs of Adult Respiratory Distress Syndrome (ARDS).
Croatian: Pojava plućnih znakova, npr. kašlja, vrućice i dispneje, zajedno s radiološkim znakovima plućnih infiltrata i oštećenjem funkcije pluća mogu biti prvi znaci sindroma respiracijskog distresa odraslih (Adult Respiratory Distress Syndrome, ARDS).
English: Assessment of progenitor cell yields
Croatian: Procjena prinosa progenitorskih stanica
English: Rare pulmonary undesirable effects including interstitial pneumonia, pulmonary oedema and pulmonary infiltrates have been reported in some cases with an outcome of respiratory failure or adult respiratory distress syndrome (ARDS) which may be fatal (see section 4.4).
Croatian: U nekim su slučajevima prijavljene rijetke plućne nuspojave, uključujući intersticijsku pneumoniju, plućni edem i plućne infiltrate, s posljedičnim zatajenjem disanja ili sindromom respiracijskog distresa odraslih (ARDS), koji mogu imati smrtni ishod (vidjeti dio 4.4).
English: What you need to know before you use Biograstim Do not use Biograstim
Croatian: Što morate znati prije nego počnete primjenjivati Biograstim
English: - if you have sickle cell disease (an inherited disease characterised by sickle-shaped red blood cells).
Croatian: - ako bolujete od anemije srpastih stanica (nasljedna bolest koju karakteriziraju crvene krvne stanice koje poprimaju oblik nalik srpu).
English: In a small number of patients (< 10 %), doses up to 1.0 MIU (10 μg)/kg/day were required to achieve reversal of neutropenia.
Croatian: U malog broja bolesnika (< 10 %) za ispravljanje neutropenije bile su nužne doze do 1,0 MIU (10 μg)/kg/dan.
English: Solution for injection or infusion
Croatian: Otopina za injekciju ili infuziju
English: - The other ingredients are: Sodium hydroxide, glacial acetic acid, sorbitol, polysorbate 80, water for injections.
Croatian: - Drugi sastojci su: Natrijev hidroksid, ledena acetatna kiselina, sorbitol, polisorbat 80, voda za injekcije.
English: Inject only the dose your doctor has told you.
Croatian: 5. Injicirajte isključivo dozu koju Vam je liječnik propisao.
English: During intermittent dosing with 30 MIU (300 μg)/day of filgrastim, there can be wide fluctuations in the patient's ANC over time.
Croatian: Pri intermitentnoj primjeni 30 MIU (300 μg) filgrastima/dan moguća su velika kolebanja ABN tijekom vremena.
English: Common (may affect up to 1 in 10 people): - elevated levels of some blood enzymes.
Croatian: Često (mogu se javiti do 1 na 10 osoba): - povišene razine nekih krvnih enzima
English: Granulocyte-colony stimulating factor can promote growth of myeloid cells in vitro and similar effects may also be seen on some non-myeloid cells in vitro.
Croatian: Čimbenik koji stimulira granulocitne kolonije može poticati rast mijeloičnih stanica in vitro, a mogući su slični učinci in vitro i na neke stanice koje nisu mijeloične.
English: In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 to 2 days after initiation of filgrastim therapy.
Croatian: U bolesnika koji primaju citotoksičnu kemoterapiju, 1 do 2 dana nakon početka primjene filgrastima obično nastupi prolazni porast broja neutrofila.
English: Undesirable effects reported with equal frequency in patients treated with filgrastim/chemotherapy and placebo/chemotherapy included nausea and vomiting, alopecia, diarrhoea, fatigue, anorexia, mucositis, headache, cough, skin rash, chest pain, generalised weakness, sore throat, constipation and unspecified pain.
Croatian: Među nuspojave koje su jednakom učestalošću prijavljivane u bolesnika koji su primali filgrastim/kemoterapiju, kao i u onih koji su primali placebo/kemoterapiju, ubrajaju se mučnina i povraćanje, alopecija, proljev, umor, anoreksija, mukozitis, glavobolja, kašalj, kožni osip, bol u prsištu, opća slabost, grlobolja, konstipacija i neodređena bol.
English: Increased haematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient positive bone-imaging findings.
Croatian: Pojačana hematopoetska aktivnost koštane srži, kao odgovor na liječenje čimbenikom rasta, bila je povezana s prolazno pozitivnim nalazima slikovnih metoda prikaza kostiju.
English: Leukapheresis should be started at day 5 and continued until day 6 if needed in order to collect 4 x 10
Croatian: Leukaferezu treba početi 5. dan i nastaviti do 6. dana, bude li potrebno, da se prikupi 4 x 106 CD34+ stanica/kg tjelesne težine primatelja.
English: 9/L individually adjusted every 1 to 2 weeks to maintain the average neutrophil count between 1.5 x 10
Croatian: Potom se doza može individualno prilagođavati svakih 1 do 2 tjedna, kako bi se broj neutrofila održavao na vrijednostima između 1,5 x 109/l i 10 x 109/l.
English: 9/L or greater have been observed in less than 5 % of patients White blood cell counts of 100 x 10 receiving filgrastim at doses above 0.3 MIU/kg/day (3 μg/kg/day).
Croatian: Broj bijelih krvnih stanica od 100 x 109/l ili veći uočen je u manje od 5 % bolesnika koji su primali filgrastim u dozama većima od 0,3 MIU/kg/dan (3 μg/kg/dan).
English: The causal association with filgrastim has not been established.
Croatian: Uzročna povezanost s primjenom filgrastima nije dokazana.
English: Biograstim is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia.
Croatian: Biograstim je indiciran za skraćivanje trajanja neutropenije i smanjenje incidencije febrilne neutropenije u bolesnika s malignim bolestima koji se liječe citotoksičnom kemoterapijom (osim kronične mijeloične leukemije i mijelodisplastičnih sindroma) i za skraćivanje trajanja neutropenije u bolesnika koji su prije presađivanja koštane srži primili mijeloablacijsku terapiju, izloženih povećanom riziku od produljene, teške neutropenije.
English: Symptoms suggestive of severe allergic reactions have been reported very rarely.
Croatian: Bilo je vrlo rijetkih prijava simptoma koji su upućivali na jake alergijske reakcije.
English: If patients with SCN develop abnormal cytogenetics, the risks and benefits of continuing filgrastim should be carefully weighed; filgrastim should be discontinued if MDS or leukaemia occur.
Croatian: Razvije li se u bolesnika s teškom kroničnom neutropenijom citogenetska abnormalnost, potrebno je pažljivo odvagnuti rizike i koristi od dalje primjene filgrastima; javi li se MDS ili leukemija, filgrastim treba obustaviti.
English: However, during the period of administration of filgrastim for PBPC mobilisation, filgrastim should be discontinued or its dosage should be reduced if the leukocyte counts rise to > 70 x 10
Croatian: No daje li se filgrastim za mobilizaciju progenitorskih stanica periferne krvi, treba ga obustaviti, ili njegovu dozu smanjiti ako broj leukocita dosegne vrijednost > 70 x 109/l.
English: Causes of transient neutropenia such as viral infections should be excluded.
Croatian: Ostale posebne mjere opreza Valja isključiti uzroke prolazne neutropenije, poput virusnih infekcija.
English: Splenic enlargement is a direct effect of treatment with filgrastim.
Croatian: Povećanje slezene izravna je posljedica primjene filgrastima.
English: This medicine contains less than 1 mmol sodium (23 mg) per pre-filled syringe, i.e. essentially ‘sodium-free'.
Croatian: Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po napunjenoj štrcaljki, tj. zanemarive količine natrija.
English: Publication Period of study
Croatian: Period studije N
English: A subset of approximately 12 % of patients who had normal cytogenetic evaluations at baseline was subsequently found to have abnormalities, including monosomy 7, on routine repeat evaluation.
Croatian: U oko 12 % bolesnika s urednim citogenetskim nalazom prije početka primjene lijeka kasnije su, pri rutinskim kontrolama nađene abnormalnosti, uključivši monosomiju
English: In a separate retrospective international study in patients with acute and chronic myelogenous leukaemias, no effect on the risk of GvHD, TRM and mortality was seen.
Croatian: U odvojenoj retrospektivnoj međunarodnoj studiji kod bolesnika s akutnom i kroničnom mijeloičnom leukemijom nije primijećen učinak na rizik od razvoja GvHD-a, smrtnosti povezane s terapijom te smrtnosti općenito.
English: Allergic reaction *See subsection “Description of selected adverse reactions” of section 4.8
Croatian: *Vidjeti odjeljak „Opis odabranih nuspojava“ dijela 4.8.
English: The incidence of fever and documented infections were not reduced in either setting.
Croatian: Ni pri jednom od tih postupaka nije se smanjila incidencija vrućice ni dokumentiranih infekcija.
English: Detailed information is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Croatian: Detaljnije informacije dostupne su na web stranici Europske agencije za lijekove http://www.ema.europa.eu.
English: Biograstim contains the active substance filgrastim.
Croatian: Biograstim sadrži djelatnu tvar filgrastim.
English: Special precautions in patients with acute myeloid leukaemia Malignant cell growth
Croatian: Posebne mjere opreza u bolesnika s akutnom mijeloičnom leukemijom Rast zloćudnih stanica
English: In normal donors, pulmonary adverse events (haemoptysis, pulmonary haemorrhage, lung infiltrates, dyspnoea and hypoxia) have been reported very rarely in postmarketing experience.
Croatian: Kod normalnih davatelja, plućne nuspojave (hemoptiza, plućno krvarenje, plućni infiltrati, dispneja i hipoksija) vrlo su rijetke u postmarketinškom periodu.
English: Yields in excess of this minimum yield appear to correlate with more rapid recovery, those below with slower recovery.
Croatian: Čini se da prinosi veći od tog minimalnog koreliraju s bržim oporavkom, a prinosi manji od minimalnog koreliraju sa sporijim oporavkom.
English: Other undesirable effects seen include splenic enlargement, which may be progressive in a minority of cases and thrombocytopenia.
Croatian: Među ostale nuspojave ubrajaju se povećanje slezene, koje u neznatnom broju slučajeva može biti progresivno, te trombocitopenija.
English: Haematuria, proteinuria
Croatian: Hematurija, proteinurija
English: Excipients: Sodium hydroxide, glacial acetic acid, sorbitol, polysorbate 80, water for injections.
Croatian: Pomoćne tvari: natrijev hidroksid, ledena acetatna kiselina, sorbitol, polisorbat 80, voda za injekcije.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Outer Wrapper Label on Multipacks With Blue Box
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Naljepnica na višestrukom pakiranju - s plavim okvirom
English: Common (may affect up to 1 in 10 people): - headache; - cough; sore throat; - constipation; loss of appetite; diarrhoea; mucositis, which is painful inflammation and ulceration of the mucous membranes lining the digestive tract; - hair loss; rash; - fatigue; generalised weakness.
Croatian: Često (mogu se javiti do 1 na 10 osoba): - glavobolja; - kašalj, grlobolja; - zatvor; gubitak apetita; proljev; mukozitis, što predstavlja bolnu upalu i ulceracije sluznice koja prekriva probavni trakt; - ispadanje kose; osip; - umor, opća slabost.
English: Use of filgrastim in patients, children or adults, with SCN (severe congenital, cyclic, and idiopathic neutropenia) induces a sustained increase in absolute neutrophil counts in peripheral blood and a reduction of infection and related events.
Croatian: Davanjem filgrastima bolesnicima, djeci i odraslima, s teškom kroničnom neutropenijom (teškom kongenitalnom, cikličkom i idiopatskom neutropenijom) inducira se održivi porast ukupnog broja neutrofila u perifernoj krvi i smanjuje incidencija infekcija i s njima povezanih događaja.
English: Contents of the pack and other information Information for injecting yourself
Croatian: Sadržaj pakiranja i druge informacije Informacije za samostalno injiciranje Sljedeće informacije namijenjene su samo za zdravstvene djelatnike
English: cells re-infused and the rate of platelet recovery after high-dose chemotherapy indicates a complex but continuous relationship.
Croatian: Statistička analiza odnosa između broja CD34+ stanica primijenjenih infuzijom i brzine oporavka broja trombocita nakon velikih doza kemoterapeutika pokazuje da je taj odnos složen, ali neprekidan.
English: As with other haematopoietic growth factors, G-CSF has shown in vitro stimulating properties on human endothelial cells.
Croatian: Pokazalo se da G-CSF, kao i ostali hematopoetski čimbenici rasta, stimulira ljudske endotelne stanice in vitro.
English: A meta-analysis of allogeneic transplant studies, including the results of nine prospective randomized trials, 8 retrospective studies and 1 case-controlled study, did not detect an effect on the risks of acute GvHD, chronic GvHD or early treatment-related mortality.
Croatian: Meta analizom studija alogenih presađivanja, uključujući i rezultate devet prospektivnih randomiziranih istraživanja, osam retrospektivnih studija te jedne studije istraživanja parova nisu pronađeni učinci na rizik od razvoja akutnog GvHD-a, kao i kroničnog GvHD-a ili rane smrtnosti povezane s terapijom.
English: Uncommon (may affect up to 1 in 100 people): - blood in the urine; protein in the urine.
Croatian: Manje često (mogu se javiti do 1 na 100 osoba): - krv u mokraći; proteini u mokraći.
English: Your doctor will monitor your blood to determine the best time to collect the stem cells.
Croatian: Liječnik će pratiti pokazatelje u Vašoj krvi, kako bi odredio najbolje vrijeme za izdvajanje matičnih stanica.
English: The syringe has a scale on the syringe barrel.
Croatian: 3. Štrcaljka ima označenu skalu na trupu.
English: SGOT increased, hyperuricaemia
Croatian: Povišena AST, hiperuricemija
English: A risk of promotion of a malignant myeloid clone can not be excluded.
Croatian: Ne može se isključiti rizik poticanja rasta klona zloćudnih mijeloičnih stanica.
English: Preclinical data from conventional studies of repeated dose toxicity revealed the expected pharmacological effects including increases in leukocyte count, myeloid hyperplasia in bone marrow, extramedullary haematopoiesis and splenic enlargement.
Croatian: Neklinički podaci dobiveni ispitivanjima toksičnosti opetovanih doza upućuju na farmakološke učinke, uključujući porast broja leukocita, mijeloičnu hiperplaziju u koštanoj srži, ekstramedularnu hematopoezu i povećanje slezene.
English: It is currently unclear whether long-term treatment of patients with SCN will predispose patients to cytogenetic abnormalities, MDS or leukaemic transformation.
Croatian: Za sada nije jasno može li dugotrajna primjena u bolesnika s teškom kroničnom neutropenijom stvoriti predispoziciju za citogenetske abnormalnosti, MDS ili leukemijsku pretvorbu.
English: The most frequent undesirable effects attributable to filgrastim were bone pain, and general musculoskeletal pain.
Croatian: Najučestalije nuspojave koje su se mogle pripisati filgrastimu bile su bol u kostima i općenito bol u mišićno-koštanom sustavu.
English: The subcutaneous route is preferred in most cases.
Croatian: U većini slučajeva daje se prednost supkutanoj primjeni.
English: Common but generally asymptomatic cases of splenomegaly and very rare cases of splenic rupture have been reported in healthy donors and patients following administration of G-CSFs.
Croatian: Prijavljivani su česti, ali općenito asimptomatski slučajevi splenomegalije, te vrlo rijetki slučajevi rupture slezene u zdravih davatelja nakon primjene G-CSF-a.
English: What Biograstim is and what it is used for What Biograstim is
Croatian: Što je Biograstim i za što se koristi
English: Special populations Elderly patients
Croatian: Stariji bolesnici
English: You will normally receive your first dose of Biograstim at least 24 hours after your chemotherapy but within 24 hours of receiving your bone marrow transfusion.
Croatian: Prvu dozu lijeka Biograstim normalno ćete primiti najmanje 24 sata nakon kemoterapije, ali unutar 24 sata nakon transfuzije koštane srži.
English: How to store Biograstim
Croatian: Kako čuvati Biograstim
English: The recommended starting dose of filgrastim is 1.0 MIU (10 μg)/kg/day given as a 30 minute or 24 hour intravenous infusion or 1.0 MIU (10 μg)/kg/day given by continuous 24 hour subcutaneous infusion.
Croatian: Preporučena dnevna doza filgrastima je 1,0 MIU (10 μg)/kg/dan u infuziji tijekom 30 minuta ili tijekom 24 sata, ili 1,0 MIU (10 μg)/kg/dan u kontinuiranoj supkutanoj infuziji tijekom 24 sata.
English: You will normally receive your first dose of Biograstim at least 24 hours after your chemotherapy.
Croatian: Prvu dozu lijeka Biograstim normalno ćete primiti najmanje 24 sata nakon kemoterapije.
English: The usual starting dose is between 0.5 million and 1.2 million international units (MIU) per kilogram bodyweight each day in a single or divided dose.
Croatian: Uobičajena početna doza je između 0,5 milijuna i 1,2 milijuna internacionalnih jedinica [MIU] po kilogramu tjelesne težine na dan, u jednoj ili u podijeljenim dozama.
English: Studies of filgrastim in patients with severe impairment of renal or hepatic function demonstrate that it exhibits a similar pharmacokinetic and pharmacodynamic profile to that seen in normal individuals.
Croatian: Bolesnici s oslabljenom funkcijom bubrega ili jetre Ispitivanja filgrastima u bolesnika s jako oslabljenom funkcijom bubrega ili jetre pokazuju da mu je farmakokinetički i farmakodinamički profil sličan kao i u zdravih osoba.
English: As a result of the potential to receive higher doses or a greater number of these medicinal products with filgrastim therapy, the patient may be at higher risk of developing thrombocytopenia and anaemia.
Croatian: Zbog mogućnosti da se pri primjeni filgrastima daje više takvih lijekova, ili da se daju u većim dozama, bolesnik može biti izložen većem riziku od trombocitopenije i anemije.
English: Normal donors are given a dose of a 10 μg/kg/day, administered subcutaneously for 4 to 5 consecutive days.
Croatian: Zdravim se davateljima daje doza od 10 μg/kg/dan supkutano tijekom 4 do 5 uzastopnih dana.
English: Treatment with filgrastim significantly reduces the duration of febrile neutropenia, antibiotic use and hospitalisation after induction chemotherapy for acute myelogenous leukaemia or myeloablative therapy followed by bone marrow transplantation.
Croatian: Primjenom filgrastima značajno se skraćuje trajanje febrilne neutropenije, vrijeme primjene antibiotika i trajanje hospitalizacije nakon indukcijske kemoterapije zbog akutne mijeloične leukemije i nakon presađivanja koštane srži, kojemu je prethodila mijeloablacijska terapija.
English: There have been reports of graft versus host disease (GvHD) and fatalities in patients receiving G-CSF after allogeneic bone marrow transplantation (see section 5.1).
Croatian: Postoje izvještaji o bolesti transplantata protiv primatelja (GvHD) kao i smrtnosti u pacijenata koji su nakon alogene transplantacije koštane srži dobivali G-CSF (vidjeti dio 5.1).
English: Each pre-filled syringe contains either 0.5 mL or 0.8 mL of solution.
Croatian: Jedna napunjena štrcaljka sadrži 0,5 ml ili 0,8 ml otopine.
English: Recipients of allogeneic PBPCs mobilised with filgrastim experienced significantly more rapid haematological recovery, leading to a significant decrease in time to unsupported platelet recovery, when compared with allogeneic bone marrow transplantation.
Croatian: U primatelja alogenih progenitorskih stanica periferne krvi mobiliziranih filgrastimom značajno brže nastupa hematološki oporavak, čime se, u usporedbi s presađivanjem koštane srži, značajno skraćuje vrijeme do oporavka trombocita bez primijenjene potpore.
English: ANC should be monitored closely, especially during the first few weeks of filgrastim therapy.
Croatian: Treba pažljivo pratiti apsolutni broj neutrofila (ABN), osobito tijekom prvih nekoliko tjedana primjene filgrastima.
English: The safety and efficacy in neonates and patients with autoimmune neutropenia have not been established.
Croatian: Sigurnost i djelotvornost primjene u bolesnika s autoimunom neutropenijom nisu ispitane.
English: Example: In a final injection volume of 20 mL, total doses of filgrastim less than 30 MIU (300 μg) should be given with 0.2 mL of 200 mg/mL (20 %) human albumin solution added.
Croatian: Primjer: U konačni volumen injekcije od 20 ml s ukupnom dozom filgrastima manjom od 30 MIU (300 μg), treba dodati 0,2 ml otopine ljudskog albumina čija je koncentracija 200 mg/ml (20%).
English: 9/L for 3 consecutive days
Croatian: > 1,0 x 109/l tijekom 3 uzastopna dana
English: Alopecia, cutaneous vasculitis, injection site pain, rash
Croatian: Alopecija, kožni vaskulitis, bol na mjestu injekcije, osip
English: Dilution to a final concentration less than 0.2 MIU (2 μg) per mL is not recommended at any time.
Croatian: Ne preporuča se razrjeđivanje do koncentracije niže od 0,2 MIU (2 μg) po ml.
English: For patients who have not had extensive chemotherapy, one < 0.5 x 10 leukapheresis is often sufficient.
Croatian: U bolesnika koji nisu primili ekstenzivnu kemoterapiju, često je dovoljna jedna leukafereza.
English: Important side effects
Croatian: Važne nuspojave
English: The recommended dose of filgrastim for PBPC mobilisation after myelosuppressive chemotherapy is 0.5 MIU (5 μg)/kg/day given daily by subcutaneous injection from the first day after completion of chemotherapy until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range.
Croatian: Preporučena doza za mobilizaciju progenitorskih stanica periferne krvi nakon mijelosupresijske kemoterapije je 0,5 MIU (5 μg)/kg/dan u supkutanoj injekciji jedanput na dan, od prvog dana po okončanju kemoterapije do prolaska očekivanog najmanjeg broja neutrofila i do normalizacije njihova broja.