FrancophonIA/ELRC3.0 huggingface dataset:
English: Revatio can only be obtained with a prescription and treatment should only be started and monitored by a doctor who has experience in the treatment of PAH.
Croatian: Revatio se izdaje samo na recept, a liječenje smije započeti i nadzirati samo liječnik s iskustvom u liječenju PAH-a.
English: This enzyme is found in the blood vessels of the lungs.
Croatian: Ovaj se enzim nalazi u krvnim žilama pluća.
English: The CHMP concluded that Revatio provides an alternative treatment option for PAH.
Croatian: CHMP je zaključio da je lijek Revatio alternativno rješenje za liječenje PAH-a.
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) decided that Revatio's benefits are greater than its risks and recommended that it be approved for use in the EU.
Croatian: Odbor za lijekove za za humanu uporabu (CHMP) pri Agenciji odlučio je da koristi od lijeka Revatio nadmašuju s njime povezane rizike te je preporučio njegovo odobrenje za korištenje u Europskoj uniji.
English: The solution for injection is for adults who cannot take Revatio tablets or oral suspension for a short period, but whose condition is stable.
Croatian: Otopina za injekciju namijenjena je odraslim osobama koje kraće vrijeme ne mogu uzimati lijek Revatio u tabletama ili oralnoj suspenziji, ali čije je stanje stabilno.
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Revatio have also been included in the summary of product characteristics and the package leaflet.
Croatian: Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Revatio nalaze se također u sažetku opisa svojstava lijeka i u uputi o lijeku.
English: What are the risks associated with Revatio?
Croatian: Koji su rizici povezani s lijekom Revatio?
English: Revatio was more effective than placebo (a dummy treatment) at improving exercise capacity in one main study in adults and another main study in children.
Croatian: Lijek Revatio pokazao se djelotvornijim od placeba (prividnog liječenja) u poboljšavanju tjelesne sposobnosti u jednom glavnom ispitivanju u odraslih osoba i drugom glavnom ispitivanju u djece.
English: Revatio must not be taken with nitrates (medicines used to treat angina), or with medicines that could affect the way that Revatio is broken down in the body, such as ketoconazole or itraconazole (antifungal medicines) and ritonavir (used to treat HIV infection).
Croatian: Lijek Revatio ne smije se primjenjivati s nitratima (lijekovima koji se koriste za liječenje angine), niti s lijekovima koji mogu utjecati na način razgradnje lijeka Revatio u tijelu, poput ketokonazola ili itrakonazola (lijekovi za liječenje gljivičnih infekcija) i ritonavira (lijek za liječenje infekcije HIV-om).
English: What measures are being taken to ensure the safe use of Revatio?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Revatio?
English: In children aged 1 to 17 years, the recommended dose is 10 mg three times a day in children weighing less than 20 kg and 20 mg three times a day in those over 20 kg. Higher doses should not be used.
Croatian: U djece u dobi od 1 do 17 godina, preporučena doza je 10 mg tri puta na dan u djece s tjelesnom težinom manjom od 20 kg i 20 mg tri puta na dan u djece s tjelesnom težinom većom od 20 kg.
English: It must not be started in patients with severe liver disease or severe hypotension (very low blood pressure), or who have recently had a stroke or heart attack, because Revatio has not been studied in these groups of patients.
Croatian: Liječenje se ne smije započinjati u bolesnika s teškim oštećenjem jetre ili teškom hipotenzijom (vrlo nizak krvni tlak), ili u bolesnika koji su nedavno imali moždani ili srčani udar jer lijek Revatio nije ispitivan na tim skupinama bolesnika.
English: The company also presented the results of studies showing that the tablets were equivalent to the oral suspension (produced similar levels of sildenafil in the blood), and that a 10 mg injection was equivalent to a 20 mg tablet.
Croatian: Tvrtka je također predočila rezultate ispitivanja u kojima je zabilježeno da su tablete istovjetne oralnoj suspenziji (proizvedene su slične razine sildenafila u krvi), te da je injekcija od 10 mg istovjetna tableti od 20 mg.
English: In adults who cannot take the tablets or oral suspension, the solution for injection is injected into a vein by a doctor or nurse at a dose of 10 mg (12.5 ml) three times a day.
Croatian: U odraslih osoba koje ne mogu uzimati tablete ili oralnu suspenziju, liječnik ili medicinska sestra ubrizgava otopinu za injekciju u venu u dozi od 10 mg (12,5 ml) tri puta na dan.
English: What benefits of Revatio have been shown in studies?
Croatian: Koje su koristi lijeka Revatio dokazane u ispitivanjima?
English: Lower doses of Revatio may be needed in patients taking some medicines that affect the way Revatio is broken down in the body.
Croatian: Niže doze lijeka mogu se propisati za liječenje bolesnika koji uzimaju pojedine lijekove koji utječu na način razgradnje lijeka Revatio u tijelu.
English: How does Revatio work?
Croatian: Kako djeluje Revatio?
English: Adults with class III disease could walk an average of 326 m at the start of the study.
Croatian: Odrasle osobe koje su imale bolest funkcionalnog stupnja III mogle su u prosjeku prehodati 326 metara na početku ispitivanja.
English: Revatio is available as tablets (20 mg), a solution for injection (0.8 mg/ml) and a powder to be made up into an oral suspension (10 mg/ml).
Croatian: Lijek Revatio dostupan je u tabletama (20 mg), kao otopina za injekciju (0,8 mg/ml) i u prahu za pripravljanje oralne suspenzije (10 mg/ml).
English: In adults, Revatio is taken at a dose of 20 mg three times a day.
Croatian: U odraslih osoba lijek Revatio uzima se u dozi od 20 mg tri puta na dan.
English: After 16 weeks, the maximum volume of oxygen the children used during exercise increased on average by 10.2% with Revatio compared with 0.5% with placebo.
Croatian: Nakon 16 tjedana najveći volumen potrošnje kisika u djece tijekom tjelovježbe u prosjeku se povećao za 10,2 % u djece koja su primala lijek Revatio, u usporedbi s 0,5 % u djece koja su primala placebo.
English: PAH is a debilitating disease where there is severe constriction (narrowing) of the blood vessels of the lungs.
Croatian: PAH je onesposobljavajuća bolest u slučaju koje postoji ozbiljna konstrikcija (suženje) krvnih žila u plućima.
English: Change in exercise capacity in this study was measured as the improvement in the maximum volume of oxygen used during exercise after 16 weeks of treatment, in children able to perform the exercise tests.
Croatian: Promjena tjelesnih sposobnosti u ovom ispitivanju izmjerena je kao povećanje najvećeg volumena potrošnje kisika tijekom tjelovježbe nakon 16 tjedana liječenja u djece koja su mogla provesti testove tjelesnog opterećenja.
English: Revatio contains the active substance sildenafil.
Croatian: Lijek Revatio sadrži djelatnu tvar sildenafil.
English: Before treatment, adults with class II disease could walk an average of 378m in 6 minutes.
Croatian: Prije početka liječenja, odrasle osobe koje su imale bolest funkcionalnog stupnja II mogle su u prosjeku prehodati 378 metara u šest minuta.
English: Revatio is a medicine used to treat adults and children from 1 year of age with pulmonary arterial hypertension (PAH, abnormally high blood pressure in the arteries of the lungs).
Croatian: Revatio je lijek koji se primjenjuje u liječenju odraslih osoba i djece u dobi od jedne godine i starije s plućnom arterijskom hipertenzijom (PAH, neuobičajeno visok krvni tlak u plućnim arterijama).
English: In patients with PAH, sildenafil widens the blood vessels of the lungs, which lowers the blood pressure and improves symptoms.
Croatian: U bolesnika s PAH-om, sildenafil širi krvne žile pluća, što smanjuje krvni tlak i ublažava simptome.
English: In children, the most common side effects (which may affect up to 1 patient in 10) are throat and nose infections, headache, vomiting, fever, diarrhoea, flu and nosebleeds.
Croatian: Najčešće nuspojave u djece (mogu se javiti u do 1 na 10 bolesnika) jesu infekcije grla i nosa, glavobolja, povraćanje, vrućica, proljev, gripa i krvarenje iz nosa.
English: Change in exercise capacity was measured as the improvement in the distance patients could walk in 6 minutes after 12 weeks of treatment.
Croatian: Promjena tjelesnih sposobnosti izmjerena je kao povećanje udaljenosti koju bolesnici mogu prehodati tijekom šest minuta nakon 12 tjedana liječenja.
English: For more information about treatment with Revatio, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Croatian: Više informacija o terapiji lijekom Revatio pročitajte u uputama o lijeku (također dio EPAR-a), odnosno obratite se svom liječniku ili ljekarniku.
English: When it is blocked, a substance called ‘cyclic guanine monophosphate' (cGMP) cannot be broken down, so that it remains in the vessels where it causes relaxation and widening of the blood vessels.
Croatian: Kada se enzim inhibira, tvar „ciklički gvanozin monofosfat” (cGMP) ne može se razgraditi te zbog toga ostaje u krvnim žilama i uzrokuje njihovo opuštanje i širenje.
English: How is Revatio used?
Croatian: Kako se Revatio koristi?
English: After 12 weeks, this distance had increased by 49 m more in the patients taking 20 mg Revatio than in the patients taking placebo.
Croatian: Nakon 12 tjedana ova se udaljenost povećala za 49 metara više u bolesnika koji su uzimali 20 mg lijeka Revatio u odnosu na bolesnike koji su uzimali placebo.
English: For practical information about using Revatio, patients should read the package leaflet or contact their doctor or pharmacist.
Croatian: Praktične informacije o primjeni lijeka Revatio pročitajte u uputi o lijeku, odnosno obratite se svom liječniku ili ljekarniku.
English: Revatio must not be taken by patients who have ever had a problem with blood flow in the eye called non-arteritic anterior ischaemic optic neuropathy (NAION).
Croatian: Lijek Revatio ne smiju uzimati bolesnici koji su imali problema s dotokom krvi u oko, tj. stanje koje se naziva nearterijska prednja ishemijska neuropatija vidnog živca.
English: In adults, Revatio is used in patients with class II (slight limitation of physical activity) or class III (marked limitation of physical activity) PAH.
Croatian: U odraslih osoba lijek Revatio primjenjuje se u liječenju bolesnika s plućnom arterijskom hipertenzijom (PAH) funkcionalnog stupnja II (s blagim ograničenjem tjelesne aktivnosti) i III (s izraženim ograničenjem tjelesne aktivnosti).
English: This distance had increased by 45 m more in the patients taking 20 mg Revatio than in those taking placebo after 12 weeks.
Croatian: Ova se udaljenost nakon 12 tjedana povećala za 45 metara više u bolesnika koji su uzimali 20 mg lijeka Revatio u odnosu na bolesnike koji su uzimali placebo.
English: The most common side effects with Revatio in adults (which may affect more than 1 patient in 10) are headache, flushing (reddening of the skin), dyspepsia (heartburn), diarrhoea and pain in arm or leg. Side effects are similar with the solution for injection.
Croatian: Najčešće nuspojave lijeka Revatio (mogu se javiti u više od 1 na 10 bolesnika) jesu glavobolja, navale crvenila (crvenilo kože), dispepsija (žgaravica), proljev i bol u ruci ili nozi.
English: For the full list of all side effects reported with Revatio, see the package leaflet.
Croatian: Potpuni popis nuspojava zabilježenih pri primjeni lijeka Revatio potražite u uputi o lijeku.
English: A/Vietnam/1203/2004 (H5N1) strain (A/Vietnam/1203/2004, MEDI 0141000136) 10
Croatian: A/Vietnam/1203/2004 (H5N1) soj (A/Vietnam/1203/2004, MEDI 0141000136) 10
English: --1 1 dose (0.2 ml) contains:
Croatian: --1 1 doza (0,2 ml) sadrži:
English: This product contains a genetically modified organism (GMO).
Croatian: Ovaj lijek sadrži genetski modificirane organizme (GMO).
English: * propagated in fertilised hens' eggs from healthy chicken flocks.
Croatian: * umnožen u oplođenim kokošjim jajima iz jata zdravih kokoši.
English: EU/1/16/1089/001 Pandemic influenza vaccine H5N1 AstraZeneca
Croatian: EU/1/16/1089/001 Pandemijsko cjepivo protiv influence H5N1
English: Nasal spray, suspension
Croatian: Sprej za nos, suspencija
English: Reassortant influenza virus* (live attenuated) of the following strain**:
Croatian: Presloženi virus influence* (živi, atenuirani) sljedećeg soja **:
English: ** produced in VERO cells by reverse genetic technology.
Croatian: ** proizveden u VERO stanicama tehnologijom reverzne genetike.
English: *** fluorescent focus units
Croatian: *** jedinice fluorescentnog žarišta
English: 10 sprayers
Croatian: 10 aplikatora
English: Nasal use sprayer (glass) in trays
Croatian: Aplikatori (stalko) na podlošcima
English: EMA Number
Croatian: Put primjene
English: (Invented) name
Croatian: EMA broj postupka (Zaštićeno) ime Doza
English: • Patients who have any questions or concerns should speak to their healthcare professional.
Croatian: • Bolesnici koji imaju bilo kakvih pitanja ili razloga za zabrinutost trebaju se obratiti svojim zdravstvenim radnicima.
English: • There are alternative treatments available in the EU.
Croatian: • Nema alternativnih liječenja na raspolaganju u EU-u.
English: Tel. +44 (0)20 3660 8427 E-mail: press@ema.europa.eu
Croatian: +44 (0)20 3660 8427 E-adresa: press@ema.europa.eu
English: Inductos was authorised centrally in the EU in September 2002.
Croatian: Inductos je u EU-u odobren centraliziranim postupkom u rujnu 2002.
English: The review of Inductos was initiated on 23 July 2015 at the request of the European Commission, under Article 20 of Regulation (EC) No 726/2004.
Croatian: Pregled lijeka Inductos pokrenut je 23. srpnja 2015. na zahtjev Europske komisije u skladu s člankom 20. Uredbe (EZ) br. 726/2004.
English: It was carried out by the Committee for Medicinal Products for Human Use (CHMP), responsible for questions concerning medicines for human use.
Croatian: Proveo ga je Odbor za lijekove za humanu uporabu (CHMP), nadležan za pitanja lijekova za ljude.
English: The CHMP recommendation was sent to the European Commission, which endorsed it and issued a final legally binding decision.
Croatian: Preporuka CHMP-a poslana je Europskoj komisiji, koja ju je potvrdila i izdala konačnu pravno obvezujuću odluku.
English: On 22 October 2015, the European Medicines Agency (EMA) recommended the suspension of Inductos, an implant used to help new bone develop in patients with spinal disc problems and leg fractures.
Croatian: Dana 22. listopada 2015., Europska agencija za lijekove (EMA) preporučila je suspenziju lijeka Inductos, usatka koji se koristi kao pomoć za razvoj nove kosti u bolesnika sa problemima kralježničnog diska i fraktura nogu.
English: The inspectors noted that the manufacturer, located in the United States, did not have adequate measures in place to prevent particle contamination of the sponges.
Croatian: Inspektori su napomenuli da proizvođač koji se nalazi u Sjedinjenim Američkim Državama, nije imao primjerene mjere na snazi kako bi spriječio kontaminaciju spužvi česticama.
English: It is used during surgery in patients with damaged spinal discs or leg (tibia) fractures.
Croatian: Koristi se tijekom kirurškog zahvata u bolesnika s oštećenim kralježničnim diskom ili frakturama noge (tibije).
English: Suspension will remain until manufacturing issues are resolved
Croatian: Suspenzija ostaje na snazi sve dok se ne razriješe pitanja proizvodnje
English: • Although there is no indication of risk to patients, Inductos has been suspended and will no longer be available in the EU until issues with the manufacturing site for the absorbable sponge are solved.
Croatian: • Iako nema indikacija rizika za bolesnike, Inductos je suspendiran i neće više biti dostupan u EU-u sve dok se problemi s proizvodnom lokacijom za apsorbirajuću spužvu ne riješe.
English: • Problems have been identified with the way the absorbable sponge in Inductos is manufactured.
Croatian: • Identificirani su problemi u načinu proizvodnje apsorbirajuće spužve u lijeku Inductos.
English: Although there is no indication of risk to patients linked to the inspection findings, EMA's Committee for Medicinal Products for Human Use (CHMP) considered that the quality of Inductos cannot be assured with the current manufacturing process.
Croatian: Iako nema indikacija rizika za bolesnike povezane s nalazima inspekcije, Odbor za lijekove za humanu uporabu (CHMP) pri EMA-i zaključio je kako se kvaliteta lijeka Inductos ne može osigurati pomoću postojećeg proizvodnog procesa.
English: EMA started a review of Inductos following an inspection by Dutch and Spanish authorities which found the manufacturing site of the absorbable sponge to be non-compliant with manufacturing requirements.
Croatian: EMA je započela pregled lijeka Inductos nakon inspekcije koju su provele nizozemske i španjolske vlasti koje su utvrdile da proizvodna lokacija za apsorbirajuću spužvu ne udovoljava proizvodnim zahtjevima.
English: The CHMP therefore concluded that Inductos should be suspended until the manufacturing issues are satisfactorily addressed.
Croatian: Stoga je CHMP zaključio da Inductos treba suspendirati sve dok se problemi proizvodnje ne riješe na zadovoljavajući način.
English: Inductos is available as a kit for implant containing a powder, solvent and absorbable collagen sponge (or matrix).
Croatian: Inductos je dostupan kao komplet za ugradnju koji sadrži prašak, otapalo i apsorbirajuću kolagensku spužvu (ili matriks).
English: Inductos to be suspended in the EU EMA/683814/2015
Croatian: EMA/683814/2015
English: The active substance is dibotermin alfa, a protein that acts on the bone structure and helps with the formation of new bone tissue.
Croatian: Djelatna tvar je dibotermin alfa, bjelančevina koja djeluje na koštane strukture i pomaže u formiranju novog koštanog tkiva.
English: The new bone tissue grows into the sponge, which is gradually degraded by the body.
Croatian: Novo koštano tkivo urasta u spužvu koju tijelo postupno razgrađuje.
English: Inductos will remain suspended until issues with the manufacturing site for one of the components of Inductos (an absorbable sponge) are resolved.
Croatian: Inductos ostaje suspendiran sve dok se problemi na proizvodnom mjestu za jednu od komponenti lijeka Inductos (apsorbirajuće spužve) ne uklone.
English: The CHMP opinion was forwarded to the European Commission, which issued a final legally binding decision applicable in all EU Member States on 20/11/2015.
Croatian: Konačno mišljenje CHMP-a proslijeđeno je Europskoj komisiji, koja je donijela konačnu pravno obvezujuću odluku primjenjivu u svim državama članicama EU-a dana
English: The volume of distribution of riluzole is about 245 ± 69 L (3.4 L/kg).
Croatian: Volumen distribucije riluzola iznosi oko 245 ± 69 L (3,4 L/kg).
English: This leaflet was last approved in {MM/YYYY}.
Croatian: Uputa je zadnji puta odobrena u {MM/GGGG}.
English: date of first authorisation: 10 June 1996 date of last renewal: 10 June 2006
Croatian: Datum posljednje obnove: 10. lipnja 2006.
English: Your doctor may want to take a blood sample to check the number of white blood cells, which are important in fighting infections.
Croatian: Liječnik će možda hjeti uzeti uzorak krvi kako bi provjerio broj bijelih krvnih stanica koje su važne u borbi protiv infekcija.
English: What RILUTEK looks like and content of the pack
Croatian: Kako RILUTEK izgleda i sadržaj pakiranja
English: RILUTEK has not been shown to be effective in the late stages of ALS.
Croatian: RILUTEK se nije pokazao djelotvornim u kasnim fazama ALS-a.
English: Undesirable effects ranked under headings of frequency are listed below, using the following convention: very common (1/10), common (1/100 to <1/10), uncommon (1/1,000 to <1/100), rare (1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Nuspojave navedene u nastavku razvrstane su prema učestalosti pojavljivanja u sljedeće kategorije: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/1000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: If you are less than 18 years of age, the use of RILUTEK is not recommended because there is no information available in this population.
Croatian: Ako ste mlađi od 18 godina, ne preporučuje se primjena lijeka RILUTEK jer nema podataka za tu populaciju.
English: The recommended daily dose in adults or older people is 100 mg (50 mg every 12 hours).
Croatian: Preporučena dnevna doza u odraslih ili starijih osoba iznosi 100 mg (50 mg svakih 12 sati).
English: If you think you may be pregnant, or if you intend to breast-feed, ask your doctor for advice before taking RILUTEK.
Croatian: Ako mislite da ste trudni ili namjeravate dojiti, obratite se svom liječniku za savjet prije nego uzmete RILUTEK.
English: Based on pharmacokinetic data, there are no special instructions for the use of RILUTEK in this population.
Croatian: Na temelju farmakokinetičkih podataka nema posebnih uputa za primjenu lijeka RILUTEK u ovoj populaciji.
English: What you need to know before you take RILUTEK
Croatian: Što morate znati prije nego počnete uzimati RILUTEK
English: ANNEX II A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Croatian: DODATAK II A. PROIZVOĐAČ(I) ODGOVORAN(ODGOVORNI) ZA PUŠTANJE SERIJE LIJEKA U PROMET B. UVJETI ILI OGRANIČENJA VEZANI UZ OPSKRBU I PRIMJENU C. OSTALI UVJETI I ZAHTJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET D. UVJETI ILI OGRANIČENJA VEZANI UZ SIGURNU I UČINKOVITU PRIMJENU LIJEKA
English: Each package contains 56 tablets.
Croatian: Jedno pakiranje sadrži 56 tableta.
English: Tell your doctor immediately if you experience any fever (increase in temperature) because RILUTEK may cause a decrease in the number of white blood cells.
Croatian: Odmah obavijestite svog liječnika ako dobijete vrućicu (povišenu temperaturu) jer RILUTEK može uzrokovati smanjenje broja bijelih krvnih stanica.
English: What RILUTEK is and what it is used for What you need to know before you take RILUTEK How to take RILUTEK
Croatian: Što je RILUTEK i za što se koristi Što morate znati prije nego počnete uzimati RILUTEK
English: OTHER SPECIAL WARNING(S), IF NECESSARY EXPIRY DATE
Croatian: DRUGA POSEBNA UPOZORENJA (AKO JE POTREBNO)
English: Therefore, RILUTEK should not be used in patients with any other form of motor neurone disease.
Croatian: Stoga se RILUTEK ne smije koristiti u bolesnika s nekim drugim oblikom bolesti motoričkih neurona.
English: IMPORTANT
Croatian: VAŽNO
English: If you take more RILUTEK than you should
Croatian: Ako uzmete više RILUTEK tableta nego što ste trebali
English: If you forget to take RILUTEK
Croatian: Ako ste zaboravili uzeti RILUTEK
English: Other medicines and RILUTEK Tell your doctor if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ako uzimate, nedavno ste uzimali ili biste mogli uzeti bilo koje druge lijekove.
English: Treatment with RILUTEK should only be initiated by specialist physicians with experience in the management of motor neurone diseases.
Croatian: Liječenje lijekom RILUTEK smije započeti samo liječnik specijalist s iskustvom u liječenju bolesti motoričkih neurona.
English: RILUTEK stops the release of glutamate and this may help in preventing the nerve cells being damaged.
Croatian: RILUTEK blokira izlučivanje glutamata, što može pomoći u sprečavanju oštećenja živčanih stanica.
English: What RILUTEK is and what it is used for
Croatian: Što je RILUTEK i za što se koristi