FrancophonIA/ELRC3.0 huggingface dataset:
English: cutaneous lupus erythematosus, pustular psoriasis or worsening psoriasis, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Croatian: kožni eritemski lupus, pustularna psorijaza ili pogoršanje psorijaze, reakcija na lijek s eozinofilijom i sistemskim simptomima (engl.
English: At a dose level of 20 mg/day, average plasma concentration of A771726 at steady state is approximately 35 µg/ml.
Croatian: Pri dozi od 20 mg/dan prosječna koncentracija A771726 u plazmi u stanju dinamičke ravnoteže iznosila je oko 35 μg/ml.
English: In a small (n=30) study with co-administration of leflunomide (10 to 20 mg per day) with methotrexate (10 to 25 mg per week) a 2- to 3-fold elevation in liver enzymes was seen on 5 of 30 patients.
Croatian: U manjem ispitivanju (n=30) istodobne primjene leflunomida (10 do 20 mg na dan) i metotreksata (10 do 25 mg na tjedan) opaženo je povišenje jetrenih enzima od 2 do 3 puta u 5 od 30 bolesnika.
English: Cases of peripheral neuropathy have been reported in patients receiving leflunomide.
Croatian: Slučajevi periferne neuropatije zabilježeni su u bolesnika koji su uzimali leflunomid.
English: As soon as skin and/or mucosal reactions are observed which raise the suspicion of such severe reactions, Leflunomide Zentiva and any other possibly associated treatment must be discontinued, and a leflunomide washout procedure initiated immediately.
Croatian: Čim se pojave reakcije na koži i/ili sluznici koje izazivaju sumnju na teške nuspojave, uzimanje lijeka Leflunomide Zentiva ili bilo kojeg dodatnog lijeka treba prekinuti i odmah započeti postupak ispiranja leflunomida.
English: In human plasma, A771726 is extensively bound to protein (albumin).
Croatian: U ljudskoj se plazmi A771726 značajno veže za proteine plazme (albumin).
English: A pharmacokinetic interaction with oral contraceptives was observed with A771726 (see below).
Croatian: Farmakokinetička interakcija s oralnim kontraceptivima primjećena je za A771726 (vidjeti ispod).
English: Colitis, including microscopic colitis has been reported in patients treated with leflunomide.
Croatian: Kolitis, uključujući mikroskopski kolitis, prijavljen je u bolesnika liječenih leflunomidom.
English: DRESS appears initially as flu-like symptoms and a rash on the face then an extended rash with a high temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes.
Croatian: DRESS se u početku javlja u vidu simptoma nalik na gripu i osipa na licu, a zatim kao prošireni osip s visokom temperaturom, povišenom razinom jetrenih enzima vidljivom na krvnim pretragama i porastom broja određenog tipa bijelih krvnih stanica (eozinofilija) te povećanim limfnim čvorovima.
English: Following concomitant administration of a single dose of leflunomide to subjects receiving multiple doses of rifampicin (non-specific cytochrome P450 inducer) A771726 peak levels were increased by approximately 40%, whereas the AUC was not significantly changed.
Croatian: Nakon istodobne primjene pojedinačne doze leflunomida u osoba koje su primale višestruke doze rifampicina (nespecifičnog induktora citokroma P450), vršne koncentracije A771726 porasle su za 40%, dok se vrijednost AUC nije značajno promijenila.
English: In other studies, unchanged leflunomide levels in plasma have rarely been detected, however, at ng/ml plasma levels.
Croatian: U ostalim ispitivanjima rijetko je zabilježena koncentracija nepromijenjenog leflunomida u plazmi (izmjerena u ng/ml).
English: Blood and lymphatic system disorders Common:
Croatian: Poremećaji krvi i limfnog sustava Često:
English: The recommended maintenance dose is leflunomide 10 mg to 20 mg once daily depending on the severity (activity) of the disease.
Croatian: Preporučena doza održavanja je 10 do 20 mg leflunomida jedanput na dan, ovisno o težini (aktivnosti) bolesti.
English: Do not take Leflunomide Zentiva when you are breast-feeding, as leflunomide passes into the breast milk.
Croatian: Nemojte uzimati lijek Leflunomide Zentiva dok dojite jer se leflunomid izlučuje u majčino mlijeko.
English: Recent, concomitant or consecutive use of potentially myelotoxic agents may be associated with a higher risk of haematological effects.
Croatian: Nedavno, istodobno ili naknadno uzimanje potencijalno mijelotoksičnih lijekova može povećati rizik od takvih hematoloških učinaka.
English: hypouricemia Psychiatric disorders Uncommon: anxiety Nervous system disorders Common:
Croatian: Psihijatrijski poremećaji Manje često: anksioznost Poremećaji živčanog sustava Često:
English: If ALT (SGPT) elevations of more than 2-fold the upper limit of normal persist or if ALT elevations of more than 3-fold the upper limit of normal are present, leflunomide must be discontinued and wash-out procedures initiated.
Croatian: Ako dvostruko veća koncentracija ALT (SGPT) u odnosu na gornju granicu normale potraje ili ako se ALT poveća više od 3 puta u odnosu na gornju granicu normale, liječenje leflunomidom valja prekinuti i započeti postupak ispiranja („washout“).
English: In case of severe haematological reactions, including pancytopenia, Leflunomide Zentiva and any concomitant myelosuppressive treatment must be discontinued and a leflunomide washout procedure initiated.
Croatian: U slučaju teških hematoloških reakcija, uključujući pancitopeniju, treba prekinuti liječenje lijekom Leflunomide Zentiva i bilo kojim istodobno primijenjenim mijelosupresivnim lijekom te početi postupak ispiranja leflunomida.
English: It has been shown in man that administration of an oral suspension of activated powdered charcoal or colestyramine leads to a rapid and significant increase in A771726 elimination rate and decline in plasma concentrations (see section 4.9).
Croatian: Zabilježeno je da peroralna primjena suspenzije aktivnog ugljika ili kolestiramina u ljudi ubrzava i značajno povećava brzinu eliminacije A771726 i smanjuje njegovu koncentraciju u plazmi (vidjeti dio 4.9).
English: Interaction studies with cimetidine (non-specific cytochrome P450 inhibitor) and rifampicin (non-specific cytochrome P450 inducer), indicate that in vivo CYP enzymes are involved in the metabolism of leflunomide only to a small extent.
Croatian: Ispitivanja interakcija s cimetidinom (nespecifični inhibitor citokroma P450) i rifampicinom (nespecifični induktor citokroma P450) pokazuju da in vivo CYP enzimi u metabolizmu leflunomida sudjeluju tek u manjoj mjeri.
English: Leflunomide can be administered with food, since the extent of absorption is comparable in the fed and fasting state.
Croatian: Leflunomid se može uzimati s hranom jer se opseg apsorpcije uz hranu može usporediti s onim kad se lijek uzima natašte.
English: Studies with both hemodialysis and CAPD (chronic ambulatory peritoneal dialysis) indicate that A771726, the primary metabolite of leflunomide, is not dialysable.
Croatian: Ispitivanja s hemodijalizom i kroničnom ambulantnom peritonealnom dijalizom upućuju da se A771726, primarni metabolit leflunomida, ne može dijalizirati.
English: Therefore, when co-administered with substrates of OAT3, such as cefaclor, benzylpenicillin, ciprofloxacin, indomethacin, ketoprofen, furosemide, cimetidine, methotrexate, zidovudine, caution is recommended.
Croatian: Stoga, preporučuje se oprez kod istodobne primjene leflunomida sa supstratima OAT3, kao što su cefaklor, benzilpenicilin, ciprofloksacin, indometacin, ketoprofen, furosemid, cimetidin, metotreksat, zidovudin.
English: Concomitant administration of hepatotoxic or haematotoxic DMARDs (e.g. methotrexate) is not advisable.
Croatian: Ne preporučuje se istodobna primjena hepatotoksičnih ili hematotoksičnih DMARD-a (npr. metotreksata).
English: It may also cause some serious allergic reactions (including Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS]), or increase the chance of a severe infection.
Croatian: Također može uzrokovati neke ozbiljne alergijske reakcije (uključujući reakciju na lijek s eozinofilijom i sistemskim simptomima, engl.
English: Serious undesirable effects might occur (e.g. hepatotoxicity, haematotoxicity or allergic reactions, see below), even if the treatment with leflunomide has been stopped.
Croatian: Ozbiljne nuspojave (npr. hepatotoksičnost, hematotoksičnost ili alergijske reakcije; vidjeti u nastavku teksta) mogu se javiti čak i nakon prestanka liječenja leflunomidom.
English: After a 2-year waiting period, the A771726 plasma concentration is measured for the first time.
Croatian: Nakon dvogodišnjeg čekanja koncentracija A771726 mjeri se prvi put.
English: Consistent with extensive protein binding A771726 has a low apparent volume of distribution (approximately 11 litres).
Croatian: Zbog ekstenzivnog vezanja za bjelančevine A771726 ima mali prividni volumen distribucije (oko 11 litara).
English: Animal pharmacology
Croatian: Farmakologija u životinja
English: severe liver injury such as hepatic failure and acute hepatic necrosis that may be fatal
Croatian: Vrlo rijetko: teško oštećenje jetre poput zatajenja jetre i akutne hepatičke nekroze koja može imati smrtni ishod
English: Leflunomide Zentiva may be taken with or without food.
Croatian: Leflunomide Zentiva s hranom, pićem i alkoholom Leflunomide Zentiva se može uzimati s hranom ili bez nje.
English: The results of a population pharmacokinetic analysis of these trials have demonstrated that paediatric patients with body weights ≤40 kg have a reduced systemic exposure (measured by Css) of A771726 relative to adult rheumatoid arthritis patients (see section
Croatian: Rezultati populacijske farmakokinetičke analize tih ispitivanja pokazuju da su pedijatrijski bolesnici tjelesne težine ≤ 40 kg imali smanjenu sistemsku izloženost (mjerenu sa Css) A771726 u odnosu na odrasle bolesnike s reumatoidnim artritisom (vidjeti dio 4.2).
English: Skin reactions
Croatian: Kožne reakcije
English: • For rheumatoid arthritis: 10 or 20 mg Leflunomide Zentiva once daily, depending on the severity of the disease.
Croatian: • Za reumatoidni artritis: 10 mg ili 20 mg lijeka Leflunomide Zentiva jedanput na dan, ovisno o težini bolesti.
English: • colestyramine 8 g is administered 3 times daily for a period of 11 days,
Croatian: • kolestiramin 8 g tri puta na dan tijekom 11 dana
English: The active metabolite of leflunomide, A771726 is suspected to cause serious birth defects when administered during pregnancy.
Croatian: Sumnja se da aktivni metabolit leflunomida, A771726, uzrokuje teške defekte novorođenčeta kad se primjenjuje tijekom trudnoće.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER PACKAGING/BLISTER PACK
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKO PAKIRANJE/BLISTER
English: Packs of 30 and 100 tablets are available.
Croatian: Dostupna su pakiranja od 30 i 100 tableta.
English: No data are available regarding treatment of patients with hepatic impairment.
Croatian: Nema raspoloživih podataka o liječenju bolesnika s oštećenom jetrenom funkcijom.
English: What you need to know before you take Leflunomide Zentiva Do not take Leflunomide Zentiva
Croatian: Što morate znati prije nego što počnete uzimati lijek Leflunomide Zentiva
English: toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme
Croatian: Vrlo rijetko: toksična epidermalna nekroliza, Stevens-Johnsonov sindrom, multiformni eritem Nepoznato:
English: Treatment duration was 12 months.
Croatian: Liječenje je trajalo 12 mjeseci.
English: A771726 plasma levels can be expected to be above 0.02 mg/L for a prolonged period.
Croatian: Očekuje se da će se koncentracija A771726 u plazmi viša od 0,02 mg/l zadržati duže vrijeme.
English: In a study in which leflunomide was given concomitantly with a triphasic oral contraceptive pill containing 30 µg ethinyloestradiol to healthy female volunteers, there was no reduction in contraceptive activity of the pill, and A771726 pharmacokinetics were within predicted ranges.
Croatian: U ispitivanju u kojem se zdravim ženama leflunomid davao istodobno s trifaznim oralnim kontraceptivima koji su sadržavali 30 μg etiniloestradiola nije zabilježena smanjena kontracepcijska aktivnost pilule, dok je farmakokinetika A771726 bila u predviđenim rasponima.
English: A pharmacodynamics interaction with warfarin was observed with A771726 in a clinical pharmacology study (see below).
Croatian: Farmakodinamička interakcija s varfarinom primjećena je za A771726 u kliničkom farmakološkom ispitivanju (vidjeti ispod).
English: • Breast-feeding women (see section 4.6).
Croatian: • Dojilje (vidjeti dio 4.6).
English: Leflunomide, administered orally and intraperitoneally, has been studied in acute toxicity studies in mice and rats.
Croatian: Akutna toksičnost leflunomida, primijenjenog oralno i intraperitonealno, ispitivana je na miševima i štakorima.
English: Leflunomide is rapidly converted to the active metabolite, A771726, by first-pass metabolism (ring opening) in gut wall and liver.
Croatian: Leflunomid se brzo metabolizira u aktivni metabolit, A771726, prvim prolaskom kroz stijenku crijeva i jetru (otvaranje prstena).
English: ANNEX III LABELLING AND PACKAGE LEAFLET
Croatian: DODATAK III OZNAČIVANJE I UPUTA O LIJEKU
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER PACKAGING/BOTTLE PACK
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKO PAKIRANJE/BOČICA
English: Talk to your doctor, pharmacist or nurse before taking Leflunomide Zentiva - if you have ever suffered from inflammation of the lung (interstitial lung disease).
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego što uzmete lijek Leflunomide Zentiva . - ako ste ikad imali upalu pluća (intersticijsku plućnu bolest) - ako ste ikad imali tuberkulozu ili ako ste bili u bliskom kontaktu s nekim tko ima ili je imao tuberkulozu.
English: 100 ml HDPE-wide-necked bottle, with screw cap with integrated desiccant container, containing either 30, 50 or 100 film-coated tablets.
Croatian: Bočica od polietilena visoke gustoće (HDPE) širokog grla, volumena 100 ml, sa zatvaračem s navojem s ugrađenim spremnikom za sredstvo za sušenje, koja sadrži 30, 50 ili 100 filmom obloženih tableta.
English: Leflunomide is a disease-modifying anti-rheumatic agent with antiproliferative properties.
Croatian: Leflunomid je antireumatik s antiproliferativnim svojstvima koji modificira tijek bolesti.
English: Alternatively, 50 g of activated powdered charcoal is administered 4 times daily.
Croatian: Alternativno, daje se 50 g aktivnog ugljena u prahu 4 puta na dan.
English: Colestyramine given orally at a dose of 8 g three times a day for 24 hours to three healthy volunteers decreased plasma levels of A771726 by approximately 40% in 24 hours and by 49% to 65% in 48 hours.
Croatian: Kolestiramin u dozi od 8 g primijenjen oralno tri puta tijekom 24 sata u tri zdrava dobrovoljca smanjio je koncentraciju A771726 u plazmi za približno 40% u 24 sata te za 49% do 65% u 48 sati.
English: - If you have any further questions, ask your doctor, pharmacist or nurse.
Croatian: - Ako imate dodatnih pitanja, obratite se svom liječniku, ljekarniku ili medicinskoj sestri.
English: Immune system disorders Common:
Croatian: Poremećaji imunološkog sustava Često:
English: severe increase in blood pressure Respiratory, thoracic and mediastinal disorders Rare:
Croatian: izraziti porast krvnog tlaka Poremećaji dišnog sustava, prsišta i sredoprsja Rijetko:
English: Leflunomide Zentiva contains lactose.
Croatian: Leflunomide Zentiva sadrži laktozu.
English: Very rare cases of Stevens Johnson syndrome or toxic epidermal necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) have been reported in patients treated with leflunomide.
Croatian: Vrlo rijetki slučajevi Stevens-Johnsonovog sindroma ili toksične epidermalne nekrolize i reakcije na lijek s eozinofilijom i sistemskim simptomima (engl.
English: Repeated doses of A771726 decreased mean Cmax and AUC of caffeine (CYP1A2 substrate) by 18% and 55%, respectively, suggesting that A771726 may be a weak inducer of CYP1A2 in vivo.
Croatian: Ponovljene doze A771726 smanjile su prosječnu Cmax i AUC kofeina (CYP1A2 supstrat) za 18%, odnosno za 55%, što ukazuje da bi A771726 mogao biti slabi induktor CYP1A2 in vivo.
English: Children and adolescents
Croatian: I DOHVATA DJECE
English: Pack sizes: 30 and 100 film-coated tablets.
Croatian: Veličine pakiranja: 30 i 100 filmom obloženih tableta.
English: Elderly
Croatian: Stariji
English: Interstitial lung disease, as well as rare cases of pulmonary hypertension have been reported during treatment with leflunomide (see section 4.8).
Croatian: Za vrijeme liječenja leflunomidom zabilježena je intersticijska plućna bolest, kao i rijetki slučajevi plućne hipertenzije (vidjeti dio 4.8).
English: Tell your doctor immediately and stop taking Leflunomide Zentiva: - if you experience weakness, feel light-headed or dizzy or have difficulty breathing, as these may be signs of a serious allergic reaction, - if you develop a skin rash or ulcers in your mouth, as these may indicate severe, sometimes life-threatening reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS]), see section
Croatian: Odmah obavijestite svog liječnika i prestanite uzimati lijek Leflunomide Zentiva: - ako osjetite slabost, ošamućenost ili omaglicu ili imate poteškoće s disanjem, jer to mogu biti znaci ozbiljne alergijske reakcije, - ako dobijete kožni osip ili čireve u ustima, jer to može upućivati na teške reakcije, ponekad opasne po život (npr. Stevens-Johnsonov sindrom, toksična epidermalna nekroliza, multiformni eritem, reakcija na lijek s eozinofilijom i sistemskim simptomima, engl.
English: If such effects occur, a washout (see below) to reduce plasma levels of A771726 should be considered.
Croatian: Ako se ti učinci pojave, treba razmotriti postupak ispiranja („washout“) (vidjeti nastavak teksta) kako bi se smanjila koncentracija A771726 u plazmi.
English: An in vivo interaction study with leflunomide and cimetidine (non-specific weak cytochrome P450 (CYP) inhibitor) has demonstrated a lack of a significant impact on A771726 exposure.
Croatian: U in vivo ispitivanjima interakcija s leflunomidom i cimetidinom (nespecifičnim slabim inhibitorom citokroma P450 (CYP)) nije opažen značajan utjecaj na izloženost A771726.
English: Treatment duration was 6 months.
Croatian: Liječenje je trajalo 6 mjeseci.
English: Administration of activated charcoal (powder made into a suspension) orally or via nasogastric tube (50 g every 6 hours for 24 hours) has been shown to reduce plasma concentrations of the active metabolite A771726 by 37% in 24 hours and by 48% in 48 hours.
Croatian: Primjenom aktivnog ugljena (prašak pripravljen kao suspenzija) oralno ili putem nazogastrične sonde (50 g svakih 6 sati tijekom 24 sata) smanjila se koncentracija aktivnog metabolita A771726 za 37% u roku od 24 sata i za 48% u roku od 48 sati.
English: Interstitial lung disease is a potentially fatal disorder, which may occur acutely during therapy.
Croatian: Intersticijska plućna bolest može imati smrtni ishod, a smrt može nastupiti iznenada tijekom liječenja leflunomidom.
English: Lactose
Croatian: Laktoza
English: There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively), following repeated doses of A771726.
Croatian: Zabilježeno je povećanje prosječne Cmax i AUC (2,65 odnosno 2,51 puta) za rosuvastatin, nakon ponovljenih doza A771726.
English: increased hair loss, eczema, rash (including maculopapular rash), pruritus, dry skin Uncommon: urticaria
Croatian: pojačani gubitak kose, ekcem, osip (uključujući makulopapularni osip), pruritus, suha koža
English: Skin and subcutaneous tissue disorders Common:
Croatian: Poremećaji kože i potkožnog tkiva Često:
English: Without a loading dose, it is estimated that attainment of steady-state plasma concentrations would require nearly two months of dosing.
Croatian: Procjenjuje se da bi bez takve udarne doze lijek bilo potrebno uzimati skoro dva mjeseca kako bi se postiglo stanje dinamičke ravnoteže koncentracija lijeka u plazmi.
English: Tell your doctor immediately if you experience: - pale skin, tiredness, or bruising, as these may indicate blood disorders caused by an imbalance in the different types of blood cells which make up blood, - tiredness, abdominal pain, or jaundice (yellow discolouration of the eyes or skin), as these may indicate serious conditions such as liver failure, which may be fatal, - any symptoms of an infection such as fever, sore throat or cough, as this medicine may increase the chance of a severe infection which may be life-threatening, - cough or breathing problems as these may indicate problems of the lung (interstitial lung disease or pulmonary hypertension), - unusual tingling, weakness or pain in your hands or feet as these may indicate problems with your nerves (peripheral neuropathy).
Croatian: Odmah obavijestite svog liječnika u slučaju: - bljedoće kože, umora ili pojave modrica, jer to može upućivati na krvne poremećaje uzrokovane poremećenom ravnotežom različitih vrsta krvnih stanica, - umora, boli u trbuhu ili žutice (žuta boja bjeloočnica ili kože), jer to može upućivati na teška stanja kao što je zatajenje jetre, koje može dovesti do smrtnog ishoda, - bilo kojeg simptoma infekcije, kao što su vrućica, grlobolja ili kašalj, jer ovaj lijek može povećati rizik od teških infekcija koje mogu biti opasne po život, - kašlja ili problema s disanjem, jer to može upućivati na probleme s plućima (intersticijska plućna bolest ili plućna hipertenzija), - neuobičajenih trnaca, slabosti li bolova u šakama ili stopalima, jer mogu upućivati na probleme sa živcima (periferna neuropatija).
English: The use of leflunomide with antimalarials used in rheumatic diseases (e.g. chloroquine and hydroxychloroquine), intramuscular or oral gold, D-penicillamine, azathioprine and other immunosuppressive agents including Tumour Necrosis Factor alpha-Inhibitors has not been adequately studied up to now in randomised trials (with the exception of methotrexate, see section 4.5).
Croatian: Do sada u randomiziranim ispitivanjima nije ispitivana primjena leflunomida s antimalaricima koji se koriste za reumatske bolesti (npr. klorokin i hidroksiklorokin), intramuskularno ili peroralno primijenjenim solima zlata, D-penicilaminom, azatioprinom te ostalim imunosupresivnim lijekovima uključujući inhibitore faktora nekroze tumora alfa (s izuzetkom metotreksata, vidjeti dio 4.5).
English: 100 ml HDPE-wide-necked bottle, with screw cap with integrated desiccant container, containing either 30 or 100 film-coated tablets.
Croatian: Bočica od polietilena visoke gustoće (HDPE) širokog grla, volumena 100 ml, sa zatvaračem s navojem s ugrađenim spremnikom za sredstvo za sušenje, koja sadrži 30 ili 100 filmom obloženih tableta.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING BOTTLE LABEL
Croatian: PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKIRANJU NALJEPNICA BOČICE
English: It contains the active substance leflunomide.
Croatian: Sadrži djelatnu tvar leflunomid.
English: Excipients with known effect Each tablet contains 138.42 mg of lactose monohydrate
Croatian: Pomoćne tvari s poznatim učinkom Jedna tableta sadrži 138,42 mg laktoze hidrata.
English: • alternatively, 50 g of activated powdered charcoal is administered 4 times daily for a period of 11 days.
Croatian: • alternativno, 50 g aktivnog ugljena u prahu 4 puta na dan tijekom 11 dana
English: All leflunomide patients in the phase III trials used an initial dose of 100 mg for 3 days.
Croatian: Svi bolesnici koji su uzimali leflunomid u ispitivanjima faze III počeli su s dozom od 100 mg tijekom 3 dana.
English: Leflunomide Zentiva contains lactose
Croatian: Leflunomide Zentiva sadrži laktozu
English: Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1.43- and 1.54-fold, respectively), following repeated doses of A771726, suggesting that A771726 is an inhibitor of OAT3 in vivo.
Croatian: Učinak na supstrate organskog anionskog transportera 3 (OAT 3) Zabilježeno je povećanje prosječne Cmax i AUC (1,43 odnosno 1,54 puta) za cefaklor, nakon ponovljenih doza A771726, što ukazuje da je A771726 inhibitor OAT3 in vivo.