FrancophonIA/ELRC3.0 huggingface dataset:
English: In the age groups 3 to <12 years (n=36) and 12 to <18 years (n=26), mean IOP reduction at Week 12 in the travoprost group was similar to that in the timolol group.
Slovenian: V starostnih skupinah od 3 let do < 12 let (n=36) in od 12 let do < 18 let (n=26) je bilo v skupini, ki je prejemala travoprost, povprečno znižanje očesnega tlaka v 12. tednu podobno kot v skupini, ki je prejemala timolol.
English: Hyperaemia (ocular or conjunctival) was observed in 11.8% of patients (N=442) exposed to IZBA compared with 14.5% observed for patients exposed to travoprost 40 µg/mL eye drops, solution, benzalkonium chloride preserved.
Slovenian: Hiperemijo (okularno ali konjunktivalno) so opazili pri 11,8 % bolnikov (N=442), ki so bili izpostavljeni zdravilu IZBA, v primerjavi s 14,5 % bolnikov, ki so bili izpostavljeni kapljicam za oko s travoprostom v odmerku 40 µg/ml, konzerviranimi z benzalkonijevim kloridom.
English: In a 3-month phase 3 study and a 7-day pharmacokinetic study, involving 102 paediatric patients exposed to travoprost 40 micrograms/mL eye drops, solution, the types and characteristics of adverse reactions reported were similar to what has been observed in adult patients.
Slovenian: V 3-mesečni študiji 3. faze in 7-dnevni študiji farmakokinetike pri 102 pediatričnih bolnikih, ki so prejemali kapljice za oko s travoprostom v odmerku 40 mikrogramov/ml, so bile vrste in značilnosti zabeleženih neželenih učinkov podobne, kot so jih opažali pri odraslih bolnikih.
English: • Do not touch the eye or eyelid, surrounding areas or other surfaces with the dropper.
Slovenian: • Ne dotikajte se očesa ali veke, kože v bližini ali drugih površin s kapalko, saj lahko pride do okužbe kapljic.
English: In children and adolescents, the most common side effects seen with the medicine containing a higher strength of travoprost (40 micrograms/mL) are eye redness and growth of eyelashes.
Slovenian: Pri otrocih in mladostnikih sta najpogostejša neželena učinka, ki so ju opazili pri zdravilu z višjo jakostjo travoprosta (40 mikrogramov/ml), rdečina očesa in rast trepalnic.
English: Uncommon hypersensitivity, seasonal allergy
Slovenian: Bolezni imunskega sistema občasni preobčutljivost, sezonska alergija
English: Travoprost significantly increased optic nerve head blood flow in rabbits following 7 days of topical ocular administration (1.4 micrograms, once-daily).
Slovenian: Travoprost znatno poveča prekrvavitev glave vidnega živca pri kuncih po 7 dneh topikalne okularne uporabe zdravila (1,4 mikrogramov, enkrat na dan).
English: Animal studies have shown excretion of travoprost and metabolites in breast milk.
Slovenian: Študije na živalih so pokazale, da se travoprost in njegovi presnovki izločajo v mleko samic.
English: In ocular toxicity studies in monkeys, administration of travoprost at a dose of 0.45 microgram, twice a day, was shown to induce increased palpebral fissure.
Slovenian: Študije očesne toksičnosti zdravila pri opicah so pokazale, da dajanje travoprosta v odmerku 0,45 mikrogramov dvakrat na dan povzroči nastanek palpebralne fisure.
English: Mean IOP reduction at Week 12 in the 2 months to <3 years of age group was 1.8 mmHg in the travoprost group and 7.3 mmHg in the timolol group.
Slovenian: V starostni skupini od 2 mesecev do < 3 let je znašalo povprečno znižanje očesnega tlaka v 12. tednu 1,8 mmHg v skupini, ki je prejemala travoprost, in 7,3 mmHg v skupini, ki je prejemala timolol.
English: The following adverse reactions were assessed to be related with IZBA monotherapy and are classified according to the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) and very rare (<1/10,000).
Slovenian: Naslednji neželeni učinki so bili ocenjeni kot povezani z zdravljenjem z zdravilom IZBA v monoterapiji in so razvrščeni v skladu z naslednjim dogovorom: zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10), občasni (≥1/1.000 do <1/100), redki (≥1/10.000 do <1/1.000) in zelo redki (<1/10.000).
English: Following topical ocular administration of travoprost 40 µg/mL eye drops, solution to healthy volunteers, low systemic exposure to active free acid was demonstrated.
Slovenian: Po topikalni okularni uporabi kapljic za oko s travoprostom v odmerku 40 µg/ml pri zdravih prostovoljcih so ugotovili majhno sistemsko izpostavljenost aktivni prosti kislini.
English: Do not open the pouch until you need to use the bottle.
Slovenian: Omota ne odprite, dokler ne boste začeli uporabljati kapalnega vsebnika.
English: If a dose is missed, treatment should be continued with the next dose as planned.
Slovenian: Če si bolnik pozabi vkapati posamezen odmerek, naj zdravljenje nadaljuje z naslednjim rednim odmerkom.
English: Each 4 mL bottle will contain 2.5 mL of solution.
Slovenian: Vsak 4-ml kapalni vsebnik vsebuje 2,5 ml raztopine.
English: IZBA should only be used as an eye drop.
Slovenian: Zdravilo IZBA uporabljajte le kot kapljice za oko.
English: IZBA contains travoprost, one of a group of medicines called prostaglandin analogues.
Slovenian: Zdravilo IZBA vsebuje travoprost, ki sodi v skupino zdravil, imenovano analogi prostaglandina.
English: In controlled clinical trials, periorbital and/or eyelid skin darkening in association with the use of IZBA has been reported in 0.2% of patients.
Slovenian: V kontroliranih kliničnih preskušanjih so poročali o potemnitvi kože okrog očesa in/ali potemnitvi kože vek ob uporabi zdravila IZBA pri 0,2 % bolnikov.
English: IZBA can be used in paediatric patients from 3 years to <18 years at the same posology as in adults (see section 5.1).
Slovenian: Zdravilo IZBA se lahko uporablja pri pediatričnih bolnikih od 3 let do < 18 let starosti z isto shemo odmerjanja kot pri odraslih (glejte poglavje 5.1).
English: Not known prostatic specific antigen increased
Slovenian: Preiskave neznana zvišana koncentracija za prostato specifičnega antigena
English: The efficacy of TRAVATAN (travoprost 40 micrograms/mL eye drops, solution) in paediatric patients from 2 months to less than 18 years of age was demonstrated in a 12-week, double-masked clinical study of travoprost compared with timolol in 152 patients diagnosed with ocular hypertension or paediatric glaucoma.
Slovenian: Učinkovitost zdravila TRAVATAN (travoprost 40 mikrogramov/ml kapljice za oko, raztopina) pri pediatričnih bolnikih, starih od 2 meseca do manj kot 18 let, so dokazali v 12-tedenski dvojno slepi klinični študiji primerjave travoprosta s timololom pri 152 bolnikih z diagnozo očesne hipertenzije ali pediatričnega glavkoma.
English: Periorbital and eye lid changes
Slovenian: Periorbitalne spremembe in spremembe očesnik vek
English: General side effects: rash or itching of the skin.
Slovenian: Splošni neželeni učinki: izpuščaji na koži ali srbenje kože.
English: The mean percent reductions in IOP from baseline to each study visit and assessment time point ranged from 28.4% to 30.7%.
Slovenian: Povprečni odstotek znižanj očesnega tlaka v primerjavi z izhodiščnim pa je ob vsakem obisku in opazovani časovni točki znašal od 8,4 % do 30,7 %.
English: • IZBA may gradually change the colour of your iris (the coloured part of your eye).
Slovenian: • Zdravilo IZBA lahko postopno spremeni barvo šarenice (obarvani del očesa).
English: A pharmacokinetic study of TRAVATAN (travoprost 40 micrograms/mL eye drops, solution) in paediatric patients aged 2 months to <18 years demonstrated low plasma exposure to travoprost free acid, with concentrations ranging from below the 10 pg/mL assay limit of quantitation (BLQ) to 54.5 pg/mL.
Slovenian: Študija farmakokinetike zdravila TRAVATAN (travoprost 40 mikrogramov/ml kapljice za oko, raztopina) pri pediatričnih bolnikih, starih od 2 mesecev do < 18 let, je pokazala nizko plazemsko izpostavljenost prosti kislini travoprosta, pri čemer so se koncentracije gibale od vrednosti pod mejo merljivosti (10 pg/ml) do 54,5 pg/ml.
English: Within each frequency grouping in Table 2, adverse reactions are presented in decreasing order of seriousness.
Slovenian: V tabeli 2 so v okviru vsake skupine pogostnosti neželeni učinki razvrščeni po padajoči resnosti.
English: Pharmacotherapeutic group: Ophthalmologicals, antiglaucoma preparations and miotics, ATC code: S01EE04
Slovenian: Farmakoterapevtska skupina: zdravila za očesne bolezni, zdravila za zdravljenje glavkoma in zdravila za zožitev zenice, oznaka ATC: S01EE04
English: The following side effects have been observed with IZBA:
Slovenian: Naslednje neželene učinke so opazili pri uporabi zdravila IZBA:
English: Travoprost has harmful pharmacological effects on pregnancy and/or the foetus/new-born child. Travoprost should not be used during pregnancy unless clearly necessary.
Slovenian: Travoprost ima škodljive farmakološke učinke na nosečnost in/ali na plod/novorojenega otroka.
English: S.A. Alcon Couvreur N.V. Rijksweg 14
Slovenian: S.A. Alcon Couvreur N.V.
English: Within each frequency grouping in Table 1, adverse reactions are presented in decreasing order of seriousness.
Slovenian: V tabeli 1 so v okviru vsake skupine pogostnosti neželeni učinki razvrščeni po padajoči resnosti.
English: IZBA can be used in children from 3 years to <18 years at the same dose as for adults.
Slovenian: Zdravilo IZBA se lahko pri otrocih v starosti od 3 let do manj kot 18 let uporablja v enakem odmerku kot pri odraslih.
English: Mean IOP reductions in the travoprost and timolol groups were similar (see Table 4).
Slovenian: Povprečni znižanji očesnega tlaka v skupini, ki je prejemala travoprost in v skupini, ki je prejemala timolol, sta bili podobni (glejte preglednico 4).
English: Travoprost free acid and its metabolites are mainly excreted by the kidneys.
Slovenian: Travoprost v obliki proste kisline in njegovi presnovki se izločajo predvsem skozi ledvice.
English: What IZBA is and what it is used for What you need to know before you use IZBA How to use IZBA
Slovenian: Kaj je zdravilo IZBA in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo IZBA Kako uporabljati zdravilo IZBA Možni neželeni učinki
English: When substituting another ophthalmic antiglaucoma medicinal product with IZBA, the other medicinal product should be discontinued and IZBA should be started the following day.
Slovenian: Pri prehodu z drugega očesnega zdravila proti glavkomu na zdravilo IZBA naj bolnik preneha uporabljati prvo zdravilo in začne uporabljati zdravilo IZBA naslednji dan.
English: Week 6
Slovenian: 6. teden povprečje
English: Month 3
Slovenian: 3. mesec povprečje
English: Skin contact with IZBA must be avoided as transdermal absorption of travoprost has been demonstrated in rabbits.
Slovenian: Bolnik se mora izogibati stiku kože z zdravilom IZBA, saj so pri kuncih dokazali, da se travoprost absorbira transdermalno.
English: System Organ class
Slovenian: Razvrstitev po organskih sistemih
English: Cartons containing 1 or 3 bottles.
Slovenian: Škatle z 1 ali s 3 kapalnimi vsebniki.
English: The most common adverse reaction associated with both IZBA and travoprost 40 µg/mL eye drops, solution is hyperaemia.
Slovenian: Najpogostejši neželeni učinek, povezan z zdravilom IZBA in kapljicami za oko s travoprostom v odmerku 40 µg/ml, je hiperemija.
English: IZBA may gradually change eyelashes in the treated eye(s); these changes were observed in about half of the patients in clinical trials and include: increased length, thickness, pigmentation, and/or number of lashes.
Slovenian: Te spremembe so opažali pri približno polovici bolnikov v kliničnih preskušanjih in mednje sodijo: podaljšanje, odebelitev, potemnitev in/ali povečanje števila trepalnic.
English: An improved safety profile has been observed for IZBA when compared to the marketed travoprost 40 µg/mL eye drops, solution (benzalkonium chloride preserved or polyquaternium-1 perserved).
Slovenian: Za zdravilo IZBA opažajo izboljšan profil varnosti v primerjavi z zdravilom na trgu, kapljicami za oko s travoprostom v odmerku 40 µg/ml (konzerviranimi z benzalkonijevim kloridom ali polikvaternijem-1).
English: Decrease of elevated intraocular pressure in adult patients with ocular hypertension or open-angle glaucoma (see section 5.1).
Slovenian: Znižanje zvišanega očesnega tlaka pri odraslih bolnikih z očesno hipertenzijo ali glavkomom z odprtim zakotjem (glejte poglavje 5.1).
English: IOP reductions for this group were based on only 6 patients in the timolol group and 9 patients in the travoprost group where 4 patients in the travoprost group versus 0 patients in the timolol group had no relevant mean IOP reduction at Week 12.
Slovenian: Povprečno znižanje očesnega tlaka v tej skupini je bilo izračunano iz podatkov samo 6 bolnikov, ki so prejemali timolol in 9 bolnikov, ki so prejemali travoprost, pri čemer pri 4 bolnikih, ki so prejemali travoprost ter 0 bolnikih, ki so prejemali timolol, ni bilo pomembnejšega znižanja povprečnega očesnega tlaka v 12. tednu.
English: Do not stop using IZBA without first speaking to your doctor or the doctor treating your child, the pressure in your eye or your child's eye will not be controlled which could lead to loss of sight.
Slovenian: Vaš očesni tlak ali očesni tlak vašega otroka ne bo nadzorovan in to lahko vodi do izgube vida.
English: Decrease of elevated intraocular pressure in paediatric patients aged 3 years to <18 years with ocular hypertension or paediatric glaucoma (see section 5.1).
Slovenian: Znižanje zvišanega očesnega tlaka pri pediatričnih bolnikih od 3 let do < 18 let starosti z očesno hipertenzijo ali pediatričnim glavkomom (glejte poglavje 5.1).
English: Pull down the eyelid with a clean finger, until there is a ‘pocket' between the eyelid and the eye.
Slovenian: S čistim prstom potegnite veko navzdol, da med veko in očesom nastane žepek, kamor boste vkapali kapljico (slika 2).
English: If more than one topical ophthalmic medicinal product is being used, the medicinal products must be administered at least 5 minutes apart.
Slovenian: Če bolnik sočasno uporablja več topikalnih očesnih zdravil, naj jih uporabi z razmikom najmanj 5 minut.
English: This may reduce the systemic absorption of medicinal products administered via the ocular route and result in a decrease in systemic adverse reactions.
Slovenian: Tako lahko zmanjša sistemsko absorpcijo in sistemske neželene učinke okularno uporabljenih zdravil.
English: What IZBA contains - The active substance is travoprost.
Slovenian: Kaj vsebuje zdravilo IZBA - Učinkovina je travoprost.
English: Studies in rabbits have shown peak concentrations of 20 ng/g of the free acid in aqueous humour one to two hours after topical dosing of travoprost 40 µg/mL eye drops, solution.
Slovenian: Študije na kuncih so pokazale najvišjo koncentracijo proste kisline v prekatni vodki 20 ng/g eno do dve uri po topikalni uporabi kapljic za oko s travoprostom v odmerku 40 µg/ml.
English: A topical overdose of travoprost may be flushed from the eye(s) with lukewarm water.
Slovenian: Prevelik topikalni odmerek travoprosta si lahko bolnik izpere iz očesa (oči) z mlačno vodo.
English: Write down the date you opened it in the space on each carton box.
Slovenian: V prostor na vsaki škatli si zapišite datum odprtja kapalnega vsebnika.
English: SIA Novartis Baltics Eesti filiaal Tel: +372 66 30 810
Slovenian: SIA “Novartis Baltics” Eesti filialas Tel: +372 66 30 810
English: To prevent contamination of the dropper tip and solution, care must be taken not to touch the eyelids, surrounding areas or other surfaces with the dropper tip of the bottle.
Slovenian: Da prepreči kontaminacijo vrha kapalnega vsebnika in raztopine, mora bolnik paziti, da se s kapalnim delom vsebnika ne dotakne vek, kože v bližini ali drugih površin.
English: Not known depression, anxiety, insomnia
Slovenian: Psihiatrične motnje neznana depresija, anksioznost, nespečnost
English: Macular oedema has been reported during treatment with prostaglandin F2a analogues.
Slovenian: Med zdravljenjem z analogi prostaglandina F2 so poročali o makularnem edemu.
English: What IZBA looks like and contents of the pack
Slovenian: Izgled zdravila IZBA in vsebina pakiranja
English: Effects in the eye: inflammation of the back of the eye, eyes appear more inset.
Slovenian: Učinki na oko: vnetje zadnjega dela očesa, izgled udrtih oči.
English: However, a modelling approach demonstrated that IOP lowering would be expected to be equivalent in paediatric patients aged 3 years and above using both IZBA and TRAVATAN (travoprost 40 micrograms/mL eye drops, solution).
Slovenian: Vendar pa so z uporabo modela pokazali, da lahko pri pediatričnih bolnikih, starih 3 leta in več, pričakujemo enakovredno znižanje zvišanega očesnega tlaka pri uporabi zdravila IZBA in zdravila TRAVATAN (travoprost 40 mikrogramov/ml kapljice za oko, raztopina).
English: In a clinical trial, patients with open-angle glaucoma or ocular hypertension treated with IZBA dosed once-daily in the evening, demonstrated intraocular pressure lowering equivalent to travoprost 40 µg/mL eye drops, solution at all on-therapy visits and time points (95% CI within ±1.0 mmHg).
Slovenian: V kliničnem preskušanju so bolnike z glavkomom z odprtim zakotjem ali zvišanim očesnim tlakom zdravili z zdravilom IZBA, odmerjenim enkrat na dan zvečer, in dokazali enako znižanje očesnega tlaka kot pri kapljicah za oko s travoprostom v odmerku 40 µg/ml ob vseh terapevtskih obiskih in časovnih točkah (95 % CI (interval zaupanja) znotraj ±1,0 mmHg).
English: Estimates based on least squares means derived from a statistical model that accounts for correlated IOP measurements within patient where primary diagnosis and baseline IOP stratum are in the model.
Slovenian: Ocene temeljijo na povprečjih po metodi najmanjših kvadratov, izpeljanih iz statističnega modela, v katerem so upoštevali korelirane meritve očesnega tlaka za posameznega bolnika, pri čemer so v model vnesli primarno diagnozo in začetni razred očesnega tlaka.
English: Patients received either travoprost 0.004% once daily or timolol 0.5% (or 0.25% for subjects younger than 3 years old) twice daily.
Slovenian: Bolniki so prejemali bodisi travoprost 0,004 % enkrat na dan ali pa timolol 0,5 % (oziroma 0,25 % pri preiskovancih, mlajših od 3 let) dvakrat na dan. Primarni cilj študije učinkovitosti je bila sprememba očesnega tlaka v 12. tednu študije glede na začetne vrednosti.
English: Aphakic patients
Slovenian: Afakični bolniki
English: Additional adverse reactions reported in paediatric patients in the 3-month paediatric study (n=77) compared to a similar trial in adults (n=185) included erythema of eyelid, keratitis, lacrimation increased, and photophobia, all reported as single events with an incidence of 1.3% versus 0.0% seen in adults.
Slovenian: Dodatni neželeni učinki, ki so bili zabeleženi pri pediatričnih bolnikih v 3-mesečni pediatrični študiji (n=77), so v primerjavi s podobnim preskušanjem pri odraslih (n=185) zajemali eritem očesne veke, keratitis, povečano solzenje in fotofobijo.
English: You may find that your vision is blurred for a time just after you use IZBA.
Slovenian: Lahko se zgodi, da bo takoj po uporabi zdravila IZBA vaš vid nekaj časa zamegljen.
English: Polyquaternium-1, polyoxyethylene hydrogenated castor oil 40 (HCO-40), boric acid, mannitol, sodium chloride, propylene glycol, sodium hydroxide and/or hydrochloric acid (to adjust pH) and purified water.
Slovenian: Polikvaternij-1, makrogolglicerol hidroksistearat, borova kislina, manitol, natrijev klorid, propilenglikol, natrijev hidroksid in/ali klorovodikova kislina (za prilagoditev pH) in prečiščena voda.
English: Periorbital and lid changes including deepening of the eyelid sulcus have been observed with prostaglandin analogues.
Slovenian: Pri analogih prostaglandina so opazili periorbitalne spremembe in spremembe vek,vključno s poglobitvijo sulkusa očesne veke.
English: Travoprost, a prostaglandin F2 analogue, is a highly selective full agonist which has a high affinity for the prostaglandin FP receptor, and reduces the intraocular pressure by increasing the outflow of aqueous humour via trabecular meshwork and uveoscleral pathways.
Slovenian: Travoprost, analog prostaglandina F2, je popolni agonist, ki je močno selektiven in ima veliko afiniteto za prostaglandinski receptor FP.
English: However, travoprost 40 µg/mL has been studied in patients with mild to severe hepatic impairment and in patients with mild to severe renal impairment (creatinine clearance as low as 14 mL/min).
Slovenian: Vendar pa so raziskovali travoprost 40 µg/ml pri bolnikih z blago do hudo jetrno okvaro in pri bolnikih z blago do hudo ledvično okvaro (očistek kreatinina le 14 ml/min).
English: Therefore, no need for dose adjustment at the lower concentration of active ingredient is anticipated.
Slovenian: Zato tudi pri nižji koncentraciji zdravilne učinkovine ni pričakovati, da bi bilo treba prilagoditi odmerek.
English: Week 2
Slovenian: 2. teden povprečje
English: Reproduction toxicity studies have been undertaken in rat, mice and rabbit by systemic route.
Slovenian: Študije vpliva na sposobnost razmnoževanja so opravili s sistemsko uporabo zdravila na podganah, miših in kuncih.
English: IZBA contains hydrogenated castor oil and propylene glycol which may cause skin reactions and irritation.
Slovenian: Zdravilo IZBA vsebuje makrogolglicerol hidroksistearat in propilenglikol, ki lahko povzročita kožne reakcije in draženje.
English: • After using IZBA, keep the eyelid closed, apply gentle pressure by pressing a finger into the corner of the eye, by the nose (picture 4) for at least 1 minute.
Slovenian: • Po uporabi zdravila IZBA držite veko zaprto, nežno pritisnite s prstom na očesni kot ob nosu
English: If IZBA is swallowed, consult your doctor or pharmacist immediately.
Slovenian: Če pride do zaužitja zdravila IZBA, se takoj posvetujte z zdravnikom ali farmacevtom.
English: IZBA is packaged in a 4 mL syndiotactic polypropylene (sPP) oval bottle with polypropylene (PP) dispensing plugs and closures presented in an overwrap.
Slovenian: Zdravilo IZBA je pakirano v 4-ml sindiotaktičen polipropilenski (sPP) ovalni kapalni vsebnik s kapalnim delom in navojno zaporko iz polipropilena (PP), pakiranim v omot.
English: - The other ingredients are: polyquaternium-1, polyoxyethylene hydrogenated castor oil 40, propylene glycol (see end of section 2), sodium chloride, boric acid, mannitol and purified water.
Slovenian: - Pomožne snovi so: polikvaternij-1, makrogolglicerol hidroksistearat, propilenglikol (glejte poglavje 2), natrijev klorid, borova kislina, manitol in prečiščena voda.
English: Rare musculoskeletal pain, arthralgia
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva redki mišično-skeletne bolečine, artralgija
English: One mL of solution contains 30 micrograms of travoprost.
Slovenian: En ml raztopine vsebuje 30 mikrogramov travoprosta.
English: How to use IZBA
Slovenian: Kako uporabljati zdravilo IZBA
English: • Twist off the cap.
Slovenian: • Odvijte zaporko.
English: Eye drops, solution (eye drops).
Slovenian: kapljice za oko, raztopina (kapljice za oko)
English: General side effects: increased allergic symptoms, headache, irregular heart beat, cough, stuffy nose, throat irritation, darkening of skin around the eye (s), skin darkening, abnormal hair texture, excessive hair growth.
Slovenian: Splošni neželeni učinki: okrepljeni alergijski simptomi, glavobol, nereden srčni utrip, kašelj, zamašen nos, draženje žrela, potemnitev kože okrog očesa (oči), potemnitev kože, neobičajna tekstura dlak, prekomerna rast dlak.
English: Travoprost 40 µg/mL eye drops, solution has been studied in patients with mild to severe hepatic impairment and in patients with mild to severe renal impairment (creatinine clearance as low as 14 mL/min).
Slovenian: Kapljice za oko s travoprostom v odmerku 40 µg/ml so raziskovali pri bolnikih z blago do hudo jetrno okvaro in pri bolnikih z blago do hudo ledvično okvaro (očistek kreatinina le 14 ml/min).