FrancophonIA/ELRC3.0 huggingface dataset:
English: Other ingredients: Poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidoneK90, E171, E223, E304, E307, fluoropolymer, polyester, silicone, aluminium, pigments (yellow95, red166, red144, black7)
Estonian: Abiained: polü(dimetüülsiloksaan, trimetüülsilüül silikaat)-kopolümerisaat, povidoonK90, E171, E223, E304, E307, fluoropolümeer, polüester, silikoon, alumiinium, pigmentvärvid (kollane95, punane166, punane144, must7).
English: In the double blind study SP512 Part I, 177 patients received rotigotine and 96 patients received placebo.
Estonian: Topeltpimedas uuringus (SP512 I osa) said 177 patsienti rotigotiini ja 96 patsienti platseebot.
English: Based on the analysis of pooled placebo-controlled clinical trials comprising a total of 1,307 Legantoand 607 placebo-treated patients, 72.5% of the patients on Leganto and 58.0% of patients on placebo reported at least one adverse reaction.
Estonian: Põhinedes kogutud platseebokontrollitud kliiniliste uuringute analüüsil, kus osales kokku 1307 Legantoga ravitavat ja 607 platseeboga ravitavat patsienti, kirjeldati vähemalt ühte kõrvaltoimet 72,5%-l Legantot kasutavatest patsientidest ja 58,0%-l platseebot kasutavatest patsientidest.
English: Clinical studies in Restless Legs Syndrome
Estonian: Kliinilised uuringud rahutute jalgade sündroomi korral
English: Women of childbearing potential should use effective contraception to prevent pregnancy during treatment with rotigotine.
Estonian: Rotigotiin-ravi ajal peavad viljastumisvõimelised naised kasutama raseduse vältimiseks toimivaid kontratseptiivseid vahendeid.
English: • For most patients, the right dose is between 8 mg and 16 mg each day.
Estonian: • Enamikule patsientidele on sobiv annus vahemikus 8 mg kuni 16 mg päevas.
English: Perception disturbances a
Estonian: Psühhiaatrilised häired tajumishäired a
English: Week 1
Estonian: 1. nädal
English: The box contains 7, 28, 30 or 84 (multipack containing 3 packs of 28) transdermal patches, individually sealed in sachets.
Estonian: Karp sisaldab 7, 28, 30 või 84 (hulgipakend, mis sisaldab 3 karpi 28 plaastriga) transdermaalset plaastrit, mis on hermeetiliselt eraldi kotikestes.
English: The efficacy of rotigotine was evaluated in 5 placebo-controlled trials with more than 1,400 patients with idiopathic Restless Legs Syndrome (RLS).
Estonian: Rotigotiini tõhusust hinnati 1400 idiopaatilise rahutute jalgade sündroomiga patsiendil viies platseebokontrollitud uuringus.
English: Boxes containing 7, 28, 30 or 84 (multipack containing 3 packs of 28) patches, which are individually sealed in sachets.
Estonian: Karbid sisaldavad 7, 28, 30 või 84 (hulgipakend, mis sisaldab 3 karpi 28 plaastriga) plaastrit, mis on hermeetiliselt eraldi kotikestes.
English: The strengths are 1 mg/24 h, 2 mg/24 h, 3 mg/24 h, 4 mg/24 h, 6 mg/24 h and 8 mg/24 h. The patches of 1 mg/24 h and 3 mg/24 h are used for the treatment of Restless Leg Syndrome, while the patches of 4 mg/24 h, 6 mg/24 h and 8 mg/24 h are used for the treatment of Parkinson's disease.
Estonian: Tugevused on: 1 mg/24 h, 2 mg/24 h, 3 mg/24 h, 4 mg/24 h, 6 mg/24 h ja 8 mg/24 h. Rahutute jalgade sündroomi raviks võib kasutada 1 mg/24 h ja 3 mg/24 h plaastreid, samas kui plaastreid 4 mg/24 h, 6 mg/24 h ja 8 mg/24 h saab kasutada Parkinsoni tõve raviks.
English: High Level Term b
Estonian: Üldtermin b
English: How to use the patch
Estonian: Kuidas plaastrit kasutada
English: • Hold the other half of the rigid release liner.
Estonian: • Hoidke kinni jäiga eemaldatava kihi teisest poolest.
English: The effects were more pronounced in female rats.
Estonian: Toime oli tuntavam emasrottidele.
English: How to use the Leganto patches
Estonian: Kuidas Leganto plaastreid kasutada
English: • Press the patch down firmly with the palm of your hand.
Estonian: • Vajutage plaastrit tugevasti peopesaga.
English: Rotigotine
Estonian: Rotigotiin
English: If you are not sure about this, talk to your doctor or pharmacist first.
Estonian: Kui te pole kindel, pidage kõigepealt nõu oma arsti või apteekriga.
English: Augmentation may occur in Restless Legs Syndrome patients.
Estonian: Rahutute jalgade sündroomiga patsientidel võib esineda augmentatsiooni.
English: Sleep attacks/sudden onset of sleep, paranoia, sexual desire disorders a
Estonian: uinumisepisoodid/äkilise uinumise episoodid, paranoia, seksuaalhäired a
English: For both primary endpoints statistically significant differences have been observed for the doses 1 mg/24 h, 2 mg/24 h and 3 mg/24 h in comparison to placebo.
Estonian: Mõlemad tulemusnäitajad olid statistiliselt oluliselt erinevad annustes 1 mg/24 h, 2 mg/24 h ja 3 mg/24 h võrreldes platseebo ravimiga.
English: For most patients with early stage Parkinson's disease, the right dose is reached within 3 or 4 weeks, at doses of 6 mg per day or 8 mg per day respectively.
Estonian: Suuremal osal varajases staadiumis Parkinsoni tõvega patsientidest jõutakse sobiva annuseni 3 või 4 nädala jooksul, milleks on vastavalt 6 mg päevas või 8 mg päevas.
English: For example, a daily dose of 14 mg may be reached by applying one patch of 6 mg/24 h and one patch of 8 mg/24 h and likewise, a daily dose of 16 mg can be reached by applying two patches of 8 mg/24 h.
Estonian: Näiteks võib päevaannus olla 14 mg, kasutades selleks ühte 6 mg/24 h ja ühte 8 mg/24 h plaastrit ja samuti võib päevase annuse 16 mg saavutada kahte 8 mg/24 h plaastrit kasutades.
English: The dose of Leganto will depend on your illness - see below.
Estonian: Leganto annus, mida peate kasutama, sõltub teie haigusest - vt allpool.
English: pruritus generalised e, skin irritation e,
Estonian: üldine pruuritus e, nahaärritus e,
English: 116 patients were switched from previous oral therapy to receive up to 8 mg/24 h of rotigotine, among these were 47 who had been treated with ropinirole up to 9 mg/day, 47 who had been treated with pramipexole up to 2 mg/day and 22 who had been treated with cabergoline up to 3 mg/day.
Estonian: Eelnevalt suukaudselt ravilt lülitati 116 patsienti saama kuni 8 mg/24 h rotigotiini; neist 47 oli eelnevalt ravitud ropinirooliga annuses kuni 9 mg ööpäevas, 47 oli saanud pramipeksooli annuses kuni 2 mg ööpäevas ja 22 patsienti oli saanud eelneva ravina kabergoliini annuses kuni 3 mg ööpäevas.
English: At the beginning of the third week, you should take Leganto 6 mg (package marked with “Week 3”).
Estonian: Kolmanda nädala alguses peaksite kasutama 6 mg Legantot (pakend märgistusega “3.
English: At the beginning of the fourth week, you should take Leganto 8 mg (package marked with “Week 4”).
Estonian: Neljanda nädala alguses peaksite kasutama 8 mg Legantot (pakend märgistusega “4.
English: Which strength patches to use The dose of Lengato will depend on your illness - see below.
Estonian: Millise tugevusega plaastreid kasutada Leganto annus, mida peate kasutama, sõltub teie haigusest - vt allpool.
English: For doses higher than 8 mg/24 h multiple patches may be used to achieve the final dose e.g. 10 mg/24 h may be reached by combination of a 6 mg/24 h and a 4 mg/24 h patch.
Estonian: Suuremate annuste kui 8 mg/24 h korral võib lõpliku annuse saavutamiseks kasutada mitut plaastrit korraga, nt annuse 10 mg/24 h võib saada 6 mg/24 h ja 4 mg/24 h plaastrite kombineerimisel.
English: It is recommended to monitor blood pressure, especially at the beginning of treatment, due to the general risk of orthostatic hypotension associated with dopaminergic therapy.
Estonian: Dopaminergilise raviga seotud ortostaatilise hüpotensiooni üldise riski tõttu on soovitatav jälgida vererõhku, eriti ravi alguses.
English: The dose recommendations made are in nominal dose.
Estonian: Annused on soovitatud nominaalannustena.
English: On the first day of treatment the patient starts with Leganto 2 mg/24 h. During the second week, the patient takes Leganto 4 mg/24 h. During the third week, he or she takes Leganto 6 mg/24 h and during the fourth week Leganto 8 mg/24 h. The packages are marked with “Week 1 (2, 3 or 4)”.
Estonian: Ravi esimesel päeval alustab patsient annusega Leganto 2 mg/24 h. Teise nädala vältel kasutab patsient plaastrit 4 mg/24 h. Kolmandal nädalal kasutab ta plaastrit Leganto 6 mg/24 h ja neljanda nädala vältel Leganto 8 mg/24 h. Pakendid on märgistatud tekstiga „1.
English: • falling
Estonian: • kukkumine
English: 4 mg of Leganto every day may be an effective dose for some patients.
Estonian: Mõnede patsientide jaoks võib efektiivne annus olla 4 mg Legantot päevas.
English: 6.6 Special precaution for disposal
Estonian: 6.6 Erihoiatused ravimi hävitamiseks
English: If you are not sure about this, talk to your doctor, pharmacist or nurse first.
Estonian: Kui te pole kindel, pidage kõigepealt nõu oma arsti, apteekri või meditsiiniõega.
English: At the end of the maintenance treatment in 91% of the subjects in the rotigotine arm, the optimal dose was the maximal dose allowed i.e. 6 mg/24 h. An improvement of 20% was seen in 48% of the subjects receiving rotigotine and in 19% of the subjects receiving placebo (Difference 29%, CI95% 18%; 39%, p<0.0001).
Estonian: Säilitusravi lõpus oli 91%-l rotigotiini saanud patsientidest rotigotiini optimaalne annus maksimaalne lubatud annus ehk 6 mg/24 h. 20%-line paranemine oli näha 48%-l rotigotiini saanud patsientidel ja 19%-l platseebot saanud patsientidel (erinevus 29% CI95% 18%; 39%, p < 0,0001).
English: Tell your doctor if you notice any changes in behaviour, thinking or both that are listed above.
Estonian: Rääkige oma arstile, kui te märkate ükskõik milliseid ülaltoodud muutusi käitumises, mõtlemises või mõlemas.
English: External heat (excessive sunlight, heating pads and other sources of heat such as sauna, hot bath) should not be applied to the area of the patch.
Estonian: Plaastri manustamiskohale ei tohiks lasta mõjuda välisel kuumusel (ülemäärane päikesekiirgus, soojenduskotid ja muud soojusallikad nagu saun, kuum vann).
English: The patients were titrated to their optimal dose of rotigotine in weekly increments of 2 mg/24 h starting at 4 mg/24 h to a maximum dose of 16 mg/24 h. In the pramipexole group, patients received 0,375 mg in the first week, 0.75 mg in the second week and were titrated further in weekly increments of 0.75 mg to their optimal dose up to a maximum of 4.5 mg/day.
Estonian: Patsiente tiitriti kuni nende jaoks optimaalse rotigotiiniannusteni astmega 2 mg/24 h nädalas, alustades annusest 4 mg/24 h kuni maksimaalse annuseni 16 mg/24 h. Pramipeksooligrupis said patsiendid esimesel nädalal 0,375 mg, teisel nädalal 0,75 mg ning tiitriti seejärel astmega 0,75 mg nädalas optimaalse annuseni, mille maksimumiks oli 4,5 mg ööpäevas.
English: See leaflet for further information.
Estonian: Vt. pakendi infolehte täiendava informatsiooni saamiseks.
English: You should discuss with your doctor if it is safe for you to drink alcohol while using Leganto.
Estonian: Enne alkoholi tarbimist küsige palun nõu oma arsti käest, kas Leganto ravi ajal on alkoholi tarbimine ohutu.
English: • psychotic disorders
Estonian: • psühhootilised häired
English: atrial fibrillation e, supraventricular tachycardia e
Estonian: kodade virvendus e, supraventrikulaarne tahhükardia e
English: hypersexuality, libido increased), insomnia, sleep disorder, abnormal dreams, impulse-control disorders a,d
Estonian: (k.a hüperseksuaalsus, suurenenud libiido), insomnia, unehäired, tavatud unenäod¸ impulsi kontrolli häired a,d
English: Motor symptoms (UPDRS Part III) improved by 6.3 ± 1.3 points in rotigotine-treated patients, and by 5.9 ± 1.3 points in the ropinirolegroup after 4 weeks of maintenance.
Estonian: Pärast 4-nädalast ravi paranesid rotigotiiniga ravitud patsientidel motoorsed nähud (UPDRS III osa) 6,3 ± 1,3 punkti võrra ja ropinirooliga ravitud patsientide motoorsed nähud 5,9 ± 1,3 punkti võrra.
English: In trials where the application sites were rotated as reflected in the instructions provided in SmPC and package leaflet, 35.7% of 830 patients using the Leganto transdermal patch, experienced application site reactions.
Estonian: Katsetes, kus manustamiskoha pooli vahetati vastavalt ravimi omaduste kokkuvõttes ja pakendi infolehel toodud juhistele, kogesid manustamiskoha reaktsioone 35,7% 830-st Leganto transdermaalseid plaastreid kasutavast patsiendist.
English: At the end of the maintenance treatment in 92% of the subjects in the rotigotine arm, the optimal dose was the maximal dose allowed i.e. 8 mg/24 h. An improvement of 20% was seen in 52% of the subjects receiving rotigotine, 68% of the subjects receiving ropinirole and 30% of the subjects receiving placebo (Difference rotigotine versus placebo 21.7%, CI95% 11.1%; 32.4%, difference ropinirole versus placebo 38.4%, CI95% 28.1%; 48.6%, difference ropinirole versus rotigotine 16.6%, CI95% 7.6%; 25.7%).
Estonian: Säilitusravi lõpus oli 92%-l rotigotiini saavatel patsientidel optimaalne annus maksimaalne lubatud annus ehk 8 mg/24 h. 20%-line paranemine oli näha 52%-l rotigotiini saanud patsientidel, 68%-l ropinirooli saanud patsientidel ja 30%-l platseebot saanud patsientidel (rotigotiini erinevus platseeboga 21,7%; CI95% 11,1%; 32,4%, ropinirooli erinevus platseeboga 38,4% CI95% 28,1%; ropinirooli erinevus rotigotiiniga 16,6%; CI95% 7,6%; 25,7%).
English: • The maximum dose is 16 mg each day.
Estonian: • Maksimumannus on 16 mg päevas.
English: At the end of the maintenance treatment an improvement of at least 30% was seen in 60% of the subjects receiving rotigotine, 67% of the subjects receiving pramipexole and 35% of the subjects receiving placebo (Difference rotigotine versus placebo 25%, CI95% 13%; 36%, difference pramipexole versus placebo 32%, CI95% 21%; 43%, difference pramipexole versus rotigotine 7%, CI95% -2%; 17%).
Estonian: Säilitusravi lõpus täheldati vähemalt 30%-list paranemist 60%-l rotigotiini saanud patsientidest, 67%-l patsientidest, kes said pramipeksooli ja 35%-l platseebot saanud patsientidest (rotigotiini erinevus platseeboga 25%; CI95% 13%; 36%, pramipeksooli erinevus platseeboga 32%; CI95% 21%; 43%, pramipeksoliini erinevus rotigotiiniga 7%; CI95% -2%; 17%).
English: Pruritus generalised, skin irritation, dermatitis contact
Estonian: üldine pruuritus, nahaärritus, kontaktdermatiit üldine lööve
English: This should be considered when prescribing rotigotine.
Estonian: Rotigotiini määramisel tuleb eelmainituga arvestada.
English: One treatment initiation pack contains 28 transdermal patches in 4 cartons with 7 patches of 2 mg, 4 mg, 6 mg, and 8 mg each, which are individually sealed in sachets.
Estonian: Ravi alustamise pakend sisaldab 28 transdermaalset plaastrit neljas pakendis, millest igaühes on 7 plaastrit tugevusega 2 mg, 4 mg, 6 mg ja 8 mg, mis on hermeetiliselt eraldi kotikestes.
English: The changes from baseline in the International RLS Rating Scale (IRLS) and CGI-item 1 (severity of illness) were primary efficacy parameters.
Estonian: Esmasteks tulemusnäitajateks olid muutused algtasemes rahvusvahelise rahutute jalgade sündroomi (RLS) hindamisskaala (IRLS) ja CGI 1 näitaja (haigestumise ägedus) järgi.
English: paranoia e, confusional state e, psychotic disorder e, delusion e, delirium e
Estonian: segasusseisund e, psühhootiline häire e, delusioon e, deliiriume
English: • feeling of heartbeat (palpitation)
Estonian: • südamepekslemine (palpitatsioonid)
English: hallucination, hallucination visual, hallucination auditory, illusion), insomnia, sleep disorder, nightmare, abnormal dreams, impulsecontrol disorders a,d
Estonian: (k.a hallutsinatsioon, visuaalne hallutsinatsioon, kuulmishallutsinatsioon, illusioon), unetus, unehäired, õudusunenäod, tavatud unenäod¸ impulsi kontrolli häired a,d
English: • Bend the patch in half.
Estonian: • Murdke plaaster pooleks.
English: • falling asleep suddenly without warning
Estonian: • äkilised uinumishood ilma eelneva unisuseta
English: Thin, matrix-type, square-shaped with rounded edges, consisting of three layers.
Estonian: Õhuke, maatriks-tüüpi, ruudukujuline, ümarate nurkadega, kolmekihiline.
English: Transparent fluoropolymer coated polyester film.
Estonian: Läbipaistev fluoropolümeerkattega polüesterkile.
English: • binge eating (eating large amount of food in a short period of time) or compulsive eating (eating more food than normal and more than needed to satisfy hunger)
Estonian: • liigsöömishoog (suure koguse toidu söömine lühikese aja jooksul) või sundsöömine (normaalsest kogusest rohkem söömine ja suurema koguse toidu söömine kui on vajalik nälja leevendamiseks).
English: In the double-blind study SP513 Part I, 213 patients received rotigotine, 227 received ropinirole and 117 patients received placebo.
Estonian: Topeltpimedas uuringus (SP513 I osa) said 213 patsienti rotigotiini, 227 patsienti ropinirooli ja 117 patsienti platseebot.
English: Regarding the functional activity at the various receptor subtypes and their distribution in the brain, rotigotine is a D2 and D3 receptor agonist acting also on D1, D4 and D5 receptors.
Estonian: Rotigotiin on D2 ja D3 retseptorite agonist ning avaldab toimet ka D1, D4 ja D5 retseptoritele, toimides vastavalt erinevate retseptorite alatüüpide funktsionaalsele aktiivsusele ja nende jaotumisele ajus.
English: Constipation e,
Estonian: suukuivus e,
English: The active substance is rotigotine.
Estonian: Toimeaine on rotigotiin.
English: Irritability
Estonian: ärritus
English: Week 3
Estonian: 3. nädal
English: • feeling weak (fatigue)
Estonian: • nõrkus (väsimus)
English: Observed in studies performed in patients with Parkinson's disease Parkinson's disease
Estonian: Täheldati uuringutes Parkinsoni tõvega patsientidel
English: At the end of maintenance, the mean UPDRS part III score had improved by 7.0 points in rotigotine-treated patients (baseline 29.6), and by 3.9 points in the placebo-group (baseline 32.0).
Estonian: Hindamise lõpul oli UPDRS III osa skoor paranenud 7 punkti rotigotiin-ravi (algtase 29,6) ja 3,9 punkti (algtase 32,0) platseebo-ravi saavatel patsientidel.
English: hallucination, hallucination visual, hallucination auditory, illusion), nightmare e,
Estonian: (k.a hallutsinatsioon, visuaalne hallutsinatsioon, kuulmishallutsinatsioon, illusioon), õudusunenäod e, paranoia e,
English: pathological gambling, stereotypy/ punding, binge eating/eating disorder b, compulsive shopping c)
Estonian: (k.a patoloogiline hasartmängude mängimine, stereotüüpsus/ sundtegutsemine, liigsöömishoog/ söömishäire b, sundostlemine c)
English: If you notice any problems with your eyesight between checks, talk to your doctor straight away.
Estonian: Juhul kui teil on vahepealsel ajal kaebusi oma silmade kohta, võtke koheselt ühendust oma arstiga.
English: The treatment initiation pack contains 28 transdermal patches in 4 cartons with 7 patches of 2 mg, 4 mg, 6 mg, and 8 mg each, individually sealed in sachets.
Estonian: Ravi alustamise pakend sisaldab 28 transdermaalset plaastrit neljas pakendis, millest igaühes on 7 plaastrit tugevusega 2 mg, 4 mg, 6 mg ja 8 mg, hermeetiliselt eraldi kotikestes.
English: • abnormal heart beat
Estonian: • ebaregulaarne südamerütm
English: Then, the patch is fold back and the second part of the release liner is removed.
Estonian: Plaaster murdub tagasi ja eemaldada tuleb teine pool ülejäänud eemaldatavast kihist.
English: The signs include: loss of muscle movement (akinesia), rigid muscles, fever, unstable blood pressure, increased heart rate (tachycardia), confusion, low level of consciousness (such as a coma).
Estonian: Tunnusteks on: lihaste liikumisvõimetus (akineesia), lihaste jäikus, palavik, vererõhu kõikumine, kiirenenud pulss (tahhükardia), segasus, teadvusehäired (nt kooma).
English: • Stick the new patch on a different area of the skin each day.
Estonian: • Kleepige uus Leganto plaaster iga päev erinevale nahapiirkonnale.
English: Transdermal patch rotigotine
Estonian: Transdermaalne plaaster rotigotiin
English: Orthostatic hypotension, hypertension
Estonian: Vaskulaarsed häired ortostaatiline hüpotensioon, hüpertensioon hüpotensioon
English: Patients taking levodopa - advanced stage of Parkinson's disease
Estonian: Patsiendid, kes tarvitavad levodopat - Parkinsoni tõve hiline (kaugelearenenud) staadium
English: If you think that too much heat has been applied, contact your doctor or pharmacist.
Estonian: Kui arvate, et plaastri pind on kokku puutunud liiga suure kuumusega, pöörduge oma arsti või apteekri poole.
English: If your doctor says you should stop Leganto,the daily dose should be lowered gradually:
Estonian: Kui teie arst ütleb teile, et peate Leganto kasutamise lõpetama, siis tuleb päevast annust vähendada järk-järgult:
English: • generalised itching, skin irritation
Estonian: • üldine sügelemine, nahaärritus
English: • Stick the patch onto a different area of skin each day.
Estonian: • Asetage plaaster iga päev erinevale nahapiirkonnale.
English: The maximum dose is 8 mg per day.
Estonian: Maksimaalne annus on 8 mg päevas.
English: • The maximum dose is 3 mg per day.
Estonian: • Maksimumannus on 3 mg päevas.
English: • movements you cannot control related to Parkinson's disease (dyskinesia)
Estonian: • Parkinsoni tõvega seotud tahtmatud liigutused (düskineesia)
English: The daily dose should be reduced in steps of 2 mg/24 h with a dose reduction preferably every other day, until complete withdrawal of Leganto (see section 4.4).
Estonian: Päevast annust tuleks vähendada 2 mg/24 h astmete kaupa, vähendades annust soovitatavalt iga kahe päeva järel kuni Leganto kasutamise täieliku lõpetamiseni (vt lõik 4.4).
English: This makes the S-shaped break in the liner open up.
Estonian: Nii avaneb kattekihis olev Skujuline avamisjoon.
English: delusion d, delirium d
Estonian: delusioon d,
English: Vision blurred, visual impairment, photopsia
Estonian: Silma kahjustused hägune nägeminee, nägemiskahjustuse, fotopsiae
English: The daily dose should be reduced in steps of 1 mg/24 h with a dose reduction preferably every other day, until complete withdrawal of Leganto (see section 4.4).
Estonian: Päevast annust tuleks vähendada 1 mg/24 h astmete kaupa, vähendades annust soovitatavalt iga kahe päeva järel kuni Leganto kasutamise täieliku lõpetamiseni (vt lõik 4.4).
English: Peripheral oedema has been observed in clinical trials conducted in patients with RLS.
Estonian: Perifeerset turset on täheldatud kliinilistes uuringutes rahutute jalgade sündroomiga patsientidel.
English: Transdermal use.
Estonian: Transdermaalne.
English: At the beginning of the second week, you should take Leganto 4 mg (package marked with “Week 2”).
Estonian: Teise nädala alguses peaksite kasutama 4 mg Legantot (pakend märgistusega “2.
English: Because the patch is administered transdermally, no effect of food and gastrointestinal conditions is expected.
Estonian: Et plaaster avaldab toimet transdermaalselt, ei mõjuta seda toimet toit ega seedetrakti haigused.
English: In trials where the application sites were rotated as reflected in the instructions provided in the SmPC and package leaflet, 34.2% of 748 patients using Leganto, experienced application site reactions.
Estonian: Katsetes, kus manustamiskoha pooli vahetati vastavalt ravimi omaduste kokkuvõttes ja pakendi infolehel toodud juhistele, kogesid manustamiskoha reaktsioone 34,2% 748-st Leganto transdermaalseid plaastreid kasutavast patsiendist.
English: The mean reduction in the “off” time was 2.5 hours in the rotigotine arm, 2.8 hours in the pramipexole arm and 0.9 hours in the placebo arm. All differences between the active treatments and placebo were statistically significant.
Estonian: Rotigotiinigrupis lühenes keskmine “off”-perioodi kestus 2,5 tundi, pramipeksooligrupis 2,8 tundi ja platseebogrupis 0,9 tundi.
English: Application and instillation site reactions a
Estonian: Üldised häired ja manustamiskoha reaktsioonid reaktsioonid kasutamis- ja manustamiskohal a
English: If your doctor says you should stop Leganto, the daily dose should be lowered gradually:
Estonian: Kui teie arst ütleb teile, et peate Leganto kasutamise lõpetama, siis tuleb Leganto päevast annust vähendada järk-järgult:
English: Only observed in Parkinson's disease patients Both indications
Estonian: Täheldati ainult Parkinsoni tõvega patsientidel
English: • redness, increased sweating, itching
Estonian: • punetus, suurenenud higistamine, sügelemine
English: • constipation, dry mouth
Estonian: • kõhukinnisus, suukuivus