FrancophonIA/ELRC3.0 huggingface dataset:
English: To calculate BSA, it is recommended to use Mosteller's equation:
Slovenian: Za izračun telesne površine je priporočljiva uporaba Mostellerjeve formule:
English: Your other hand will be free to move the plunger of the syringe.
Slovenian: Svojo drugo prosto roko uporabite za premikanje bata brizge.
English: Study NV15495 specifically recruited patients with a histological diagnosis of cirrhosis (about 80%) or transition to cirrhosis (about 20%).
Slovenian: Študija NV15495 je specifično vključevala bolnike s histološko diagnozo ciroze (okoli 80 %) ali prehoda v cirozo (okoli 20 %).
English: More frequent monitoring of hepatic function was recommended in all instances.
Slovenian: Pri vseh primerih so priporočali pogostejše spremljanje jetrne funkcije.
English: What Pegasys is and what it is used for What you need to know before you use Pegasys How to use Pegasys
Slovenian: Kaj je zdravilo Pegasys in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Pegasys Kako uporabljati zdravilo Pegasys
English: May cause toxic reactions and allergic reactions in infants and children up to 3 years old.
Slovenian: Lahko povzroči toksične in alergijske reakcije pri dojenčkih in otrocih do 3. leta starosti.
English: Patients in groups A and C (n=111) were treated with Pegasys once weekly for 48 weeks according to BSA categories, whereas patients in group B were observed for a period of 48 weeks (principal observation period).
Slovenian: Bolnike iz skupin A in C (n = 111) so zdravili z zdravilom Pegasys enkrat na teden 48 tednov glede na telesno površino, razdeljeno v kategorije, bolnike iz skupine B pa so opazovali 48 tednov (glavno obdobje opazovanja).
English: Keep the protective cap on the pre-filled pen until Step 5.
Slovenian: Pustite zaščitni pokrovček na napolnjenem injekcijskem peresniku do koraka 5.
English: Be sure not to touch the cleaned area prior to injection.
Slovenian: Ne dotikajte se očiščenega mesta, preden si date injekcijo.
English: p value
Slovenian: p-vrednost
English: In some cases, dose modification may be necessary (see section 4.2).
Slovenian: V nekaterih primerih je treba odmerek prilagoditi (glejte poglavje 4.2).
English: < 250 cells/mm3 (or febrile neutropenia): discontinue treatment.
Slovenian: < 250 celic/mm3 (ali febrilna nevtropenija): ukinitev zdravljenja.
English: 24 weeks or 48 weeks
Slovenian: 24 ali 48 tednov
English: ● any part of the pre-filled pen appears to be damaged
Slovenian: • kateri koli del napolnjenega injekcijskega peresnika izgleda poškodovan;
English: Positive
Slovenian: Pozitiven
English: The expected benefit of treatment should be carefully weighed against the safety findings observed for children and adolescents in the clinical trials on a case by case basis (see sections 4.8 and 5.1).
Slovenian: Pričakovano korist zdravljenja je treba pri vsakem primeru posebej skrbno pretehtati glede na znane izsledke kliničnih preskušanj o varnosti pri otrocih in mladostnikih (glejte poglavji 4.8 in 5.1).
English: < 10 g/dl, and ≥ 8.5 g/dl
Slovenian: < 10 g/dl in ≥ 8,5 g/dl
English: Tell your doctor if you are taking medicines for asthma, because the dose for your asthma medicine may need to be changed.
Slovenian: Če jemljete zdravila proti astmi, to povejte svojemu zdravniku, ker bo zdravnik morda moral prilagoditi odmerek zdravila proti astmi.
English: Exposure to didanosine or its active metabolite (dideoxyadenosine 5'-triphosphate) is increased in vitro when didanosine is coadministered with ribavirin.
Slovenian: Izpostavljenost didanozinu ali njegovemu aktivnemu presnovku (dideoksiadenozin 5`- trifosfat) je povečana in vitro, če didanozin jemljemo sočasno z ribavirinom.
English: ● Hold the vial and syringe in one hand and turn the vial and the syringe upside down (4).
Slovenian: ● Vialo in brizgo primite v eno roko in ju obrnite navzgor (4).
English: You should inject your regularly scheduled dose immediately on Friday and take your next injection on Wednesday (5 days after your Friday dose).
Slovenian: V petek si takoj injicirajte priporočeni odmerek, naslednji odmerek pa si injicirajte v sredo (5 dni po petkovem odmerku).
English: No dose adjustment is required for adult patients with mild or moderate renal impairment.
Slovenian: Prilagoditev odmerka pri odraslih bolnikih z blago ali zmerno ledvično okvaro ni potrebna.
English: Dose adjustment for adverse reactions in adult patients
Slovenian: Prilagajanje odmerkov zaradi neželenih učinkov pri odraslih bolnikih
English: ● Do not touch the tip of the pre-filled pen, since needlestick injuries may occur.
Slovenian: • Ne dotikajte se konice napolnjenega injekcijskega peresnika, ker lahko pride do poškodb (vboda z iglo).
English: Adjustments in the recommended dosage of 180 micrograms once weekly are not necessary when instituting Pegasys therapy in elderly patients (see section 5.2).
Slovenian: Prilagoditve priporočenega odmerka 180 mikrogramov enkrat na teden pri uvajanju zdravljenja z zdravilom Pegasys pri starejših bolnikih niso potrebne (glejte poglavje 5.2).
English: The pharmacokinetics of Pegasys after single subcutaneous injections was comparable between male and female healthy subjects.
Slovenian: Farmakokinetika zdravila Pegasys je bila po enkratni podkožni injekciji med zdravimi moškimi in ženskami primerljiva.
English: The side effect may develop at various time points during treatment, typically several months after starting treatment with Pegasys.
Slovenian: Neželeni učinek se lahko pojavi ob različnih časovnih točkah zdravljenja, običajno nekaj mesecev po začetku zdravljenja z zdravilom Pegasys.
English: Do not exceed the recommended dose.
Slovenian: Priporočenega odmerka ne smete prekoračiti.
English: Unless otherwise noted, the management of all other toxicities should follow the adult recommendations.
Slovenian: Pri obravnavi vseh ostalih toksičnostih je treba slediti priporočilom za odrasle, razen če ni navedeno drugače.
English: ● Check for air bubbles in the syringe.
Slovenian: ● Preverite, če so v brizgi zračni mehurčki.
English: ● if you have a problem with your liver other than hepatitis B or C.
Slovenian: • če imate težave z jetri in vzrok ni hepatitis B ali C,
English: Patients should be closely monitored during therapy and even after treatment discontinuation.
Slovenian: Bolnike je treba skrbno spremljati med zdravljenjem in tudi po njegovem zaključku.
English: 16 weeks(a) or 24 weeks
Slovenian: 16 tednov(a) ali
English: Use Pegasys exactly as described by your doctor, for as long as prescribed by your doctor.
Slovenian: Zdravilo Pegasys uporabljajte natančno po zdravnikovih navodilih in tako dolgo, kot vam je predpisal zdravnik.
English: If it is not used within 5 minutes, the pre-filled pen should be disposed and a new pre-filled pen should be used.
Slovenian: Če ga ne uporabite v 5 minutah, je treba napolnjeni injekcijski peresnik zavreči in uporabiti novega.
English: Pegasys treatment may be initiated or continued if TSH levels can be maintained in the normal range by pharmaceutical means.
Slovenian: Zdravljenje z zdravilom Pegasys lahko začnemo ali nadaljujemo, če lahko z zdravilom vzdržujemo koncentracije TSH v normalnih mejah.
English: ● if you have thyroid disease that is not well controlled with medicines.
Slovenian: • če imate bolezen ščitnice, ki ni popolnoma nadzorovana z zdravili,
English: Needle-shield (only visible once cap is removed in Step 5)
Slovenian: Ščitnik za iglo (viden samo, ko je pokrovček odstranjen v koraku 5)
English: SI unit = µmol/l)
Slovenian: SI-enote (µmol/l)
English: Excipient with known effect: Benzyl alcohol (10 mg/ 1 ml) For the full list of excipients, see section 6.1.
Slovenian: Pomožna snovi z znanim učinkom: benzilalkohol (10 mg/1 ml) Za celoten seznam pomožnih snovi glejte poglavje 6.1.
English: While holding pre-filled pen firmly in place, press the activation button with your thumb and immediately release the button.
Slovenian: Ko trdno držite napolnjeni injekcijski peresnik, s palcem pritisnite sprožilni gumb in ga nemudoma spustite.
English: ● Select the injection site in the abdomen or thigh (except your navel or waistline).
Slovenian: ● Izberite mesto injiciranja na trebuhu ali stegnu (razen področje popka in pasu).
English: A total of 283/1351 (21%) of patients had advanced fibrosis or cirrhosis, 85/1351 (6%) had cirrhosis.
Slovenian: Skupno 283 od 1351 bolnikov (21 %) je imelo napredovalo fibrozo ali cirozo, 85 od 1351 bolnikov (6 %) pa je imelo cirozo.
English: ● if you develop symptoms associated with depression (e.g. feelings of sadness, dejection, etc.) (see section 4).
Slovenian: • če se pojavijo simptomi, povezani z depresijo (kot npr. občutek žalosti, potrtosti itd.) (glejte poglavje 4),
English: Peginterferon alfa-2a serum concentrations are sustained throughout one full week (168 hours).
Slovenian: Koncentracije peginterferona alfa-2a v serumu so bile nespremenjene en teden (168 ur).
English: Monotherapy for hepatitis C should only be considered in case of contraindication to other medicinal products.
Slovenian: Samostojno zdravljenje hepatitisa C uvedemo le v primerih kontraindikacij drugih zdravil.
English: The mean exposure (AUC) during the dosing interval is predicted to be 25% to 70% higher than that observed in adults receiving 180 mcg fixed dosing.
Slovenian: Predvideva se, da naj bi bila povprečna izpostavljenost (AUC) med intervali odmerjanja od 25 % do 70 % višja od tiste, ki so jo opazili pri odraslih, ki so prejemali stalen odmerek 180 µg.
English: The recommended total duration of therapy is 48 weeks.
Slovenian: Priporočeno skupno trajanje zdravljenja je 48 tednov.
English: Table 3: Dose adjustment for adverse reactions in adult patients (for further guidance see also text above)
Slovenian: Preglednica 3: Prilagajanje odmerkov zaradi neželenih učinkov pri odraslih bolnikih (za nadaljnja navodila glejte tudi zgornje besedilo).
English: A puncture-proof container with lid for safe disposal of used pens
Slovenian: Zabojnik za ostre predmete s pokrovom za varno odstranjevanje rabljenih injekcijskih peresnikov
English: If this reaction occurs, they should be advised to rinse out their mouth thoroughly afterwards.
Slovenian: Če se pojavi bruhanje, je treba bolnikom svetovati, naj si takoj zatem temeljito izperejo usta.
English: Ribavirin therapy is contraindicated in women who are pregnant.
Slovenian: Zdravljenje z ribavirinom je pri nosečnicah kontraindicirano.
English: ● Insert the needle all the way into the pinched skin at an angle of 45° to 90° (6).
Slovenian: ● Iglo pod kotom 45° do 90° do konca potisnite v kožno gubo (6).
English: Paediatric patients 5 years of age and older
Slovenian: Pediatrični bolniki, stari 5 let in več
English: Paediatric patients 3 years of age and older
Slovenian: Pediatrični bolniki, stari 3 leta in več
English: NPV= negative predictive value; Sensitivity = % of all responders not meeting the stopping rule; Specificity = % of all non-responders meeting stopping rule (a)
Slovenian: NPV = negativna napovedna vrednost; občutljivost = % vseh odzivnih bolnikov, ki ne izpolnjujejo merila za prekinitev zdravljenja; specifičnost = % vseh neodzivnih bolnikov, ki izpolnjujejo merilo za prekinitev zdravljenja.
English: Transient rashes do not necessitate interruption of treatment.
Slovenian: Pri pojavu prehodnega izpuščaja prekinitev zdravljenja ni potrebna.
English: 1-5% of patients treated with Pegasys developed neutralising anti-interferon antibodies.
Slovenian: Pri 1 do 5 % bolnikov, ki so se zdravili z zdravilom Pegasys, so se pojavila nevtralizirajoča protitelesa proti interferonu.
English: 5) Remove cap
Slovenian: 5) Odstranite pokrovček
English: Prior to initiation of Pegasys therapy, TSH and T4 levels should be evaluated.
Slovenian: Pred začetkom zdravljenja z zdravilom Pegasys moramo določiti koncentracije TSH in T4.
English: No single biomarker with a cut-off can be identified to optimize all the operating characteristics (negative predictive value [NPV], sensitivity, specificity) and practical characteristics (simplicity, convenience).
Slovenian: Posamezen biološki označevalec z znano pražno vrednostjo ter optimalnimi značilnostmi (negativna napovedna vrednost (NPV - negative predicitve value)), občutljivost, specifičnost) in praktično uporabnostjo (preprostost, prikladnost), ni poznan.
English: ● if you are an adult who has or had a history of substance abuse (e.g. alcohol or drugs)
Slovenian: • če ste odrasli in imate ali ste imeli v anamnezi zlorabo psihoaktivnih substanc (alkohol ali droge),
English: Some people get depressed when taking Pegasys alone or in combination treatment with ribavirin, and in some cases people have had suicidal thoughts or aggressive behaviour (sometimes directed against others such as thoughts about threatening the life of the others).
Slovenian: Nekateri bolniki so po jemanju zdravila Pegasys, samega ali v kombinaciji z ribavirinom, postali depresivni, v nekaterih primerih pa so imeli samomorilske misli ali so se vedli agresivno (včasih proti drugim osebam, npr. razmišljanje o umoru).
English:  The pre-filled pen is now unlocked and ready for injection.
Slovenian:  Napolnjeni injekcijski peresnik je tako odklenjen in pripravljen za injiciranje.
English: In some cases, dose reduction to 90 micrograms or 45 micrograms is necessary.
Slovenian: V nekaterih primerih moramo odmerek zmanjšati na 90 mikrogramov ali
English: ● Wait for the area to dry.
Slovenian: ● Počakajte, da se koža posuši.
English: Study WV16240 recruited patients who were positive for HBeAg, while study WV16241 recruited patients who were negative for HBeAg and positive for anti-HBe.
Slovenian: V študijo WV16240 so bili vključeni bolniki, ki so bili HBeAg pozitivni, v študijo WV16241 pa so bili vključeni HBeAg negativni in anti-HBe pozitivni bolniki.
English: Anti-interferon antibodies
Slovenian: Protitelesa proti interferonu
English: Therefore, the combination of Pegasys with telbivudine is contraindicated (see section 4.3).
Slovenian: Kombinacija zdravila Pegasys in telbivudina je zato kontraindicirana (glejte poglavje 4.3).
English: For persistent or increasing elevations ≥5 but <10 x ULN, reduce dose with a 1 level adjustment and monitor weekly ALT level to ensure it is stable or decreasing.
Slovenian: Pri dolgotrajno zvišanih vrednostih ali zviševanju vrednosti ≥ 5, vendar < 10-krat ULN - zmanjšanje odmerka 1. stopnje in tedensko spremljanje vrednosti ALT, da se prepričamo, ali so vrednosti stabilne oziroma se zmanjšujejo.
English: Dental and periodontal disorders
Slovenian: Zobne in periodontalne bolezni
English: If VKH syndrome is suspected, antiviral treatment should be withdrawn and corticosteroid therapy discussed (see section 4.8).
Slovenian: Če sumimo na VKH sindrom, je treba protivirusno zdravljenje prekiniti in razmisliti o zdravljenju s kortikosteroidi (glejte poglavje 4.8).
English: Undesirable effects reported in clinical studies are grouped according to frequency as follows: very common (≥ 1/10), common
Slovenian: Neželeni učinki, o katerih so poročali v kliničnih preskušanjih, so navedeni po pogostnosti na naslednji način: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do
English: Most laboratory abnormalities noted during the clinical trial returned to baseline levels shortly after discontinuation of treatment.
Slovenian: Večina laboratorijskih nepravilnosti, ki so jih opazili med kliničnim preskušanjem se je kmalu po prekinitvi zdravljenja vrnila na izhodiščne vrednosti.
English: For adults, dose reduction is recommended if the absolute neutrophil count (ANC) is 500 to < 750 cells/mm3.
Slovenian: Pri odraslih je zmanjšanje odmerka priporočljivo, če je absolutno število nevtrofilcev (ANC - Absolute Neutrophil Count) 500 do < 750 celic/mm3.
English: Do not warm up pre-filled pen in any other way.
Slovenian: Napolnjenega injekcijskega peresnika ne segrevajte na kakršen koli drug način.
English: 7) Give injection
Slovenian: 7) Dajte injekcijo
English: In combination therapy with ribavirin, take notice of the respective informing texts of ribavirin containing medicinal products.
Slovenian: Pri kombiniranem zdravljenju z ribavirinom bodite pozorni na ustrezno besedilo v informacijah o zdravilih, ki vsebujejo ribavirin.
English: Make sure you have taken your thumb off the activation button.
Slovenian: Odstranite palec s sprožilnega gumba.
English: values return to > 1000 cells/mm3.
Slovenian: ne vrnejo na > 1000 celic/mm3.
English: From mass balance, tissue distribution and whole body autoradioluminography studies performed in rats, peginterferon alfa-2a is distributed to the liver, kidney and bone marrow in addition to being highly concentrated in the blood.
Slovenian: Raziskave masnega ravnovesja, porazdelitve po tkivih in raziskave avtoradioluminografije celega telesa pri podganah so pokazale, da se peginterferon alfa-2a porazdeljuje v jetra, ledvice in kostni mozeg poleg tega, da je visoko koncentriran v krvi.
English: Store the container out of reach of children at all times.
Slovenian: Zabojnik za ostre predmete ves čas shranjujte izven dosega otrok.
English: Response at End of Treatment
Slovenian: Odziv na koncu zdravlje nja
English: If you forget to take Pegasys
Slovenian: Če ste pozabili vzeti zdravilo Pegasys
English: Adult and paediatric patients with preexisting ophthalmologic disorders (e.g., diabetic or hypertensive retinopathy) should receive periodic ophthalmologic exams during Pegasys therapy.
Slovenian: Odrasli in pediatrični bolniki s predhodnimi oftalmološkimi boleznimi (npr. diabetična ali hipertenzivna retinopatija) morajo med zdravljenjem z zdravilom Pegasys opravljati periodične oftalmološke preglede.
English: The PK model developed from this study shows a linear influence of BSA on the apparent clearance of the drug over the age range studied.
Slovenian: Farmakokinetični model, ki so ga razvili iz te študije, kaže linerani vpliv telesne površine na navidezni očistek zdravila v starostnem območju, ki so ga preučevali.
English: The Child-Pugh scoring may be affected by factors related to treatment (i.e. indirect hyperbilirubinemia, decreased albumin) and not necessarily attributable to hepatic decompensation.
Slovenian: Na število točk po Child-Pughovi lestvici lahko vplivajo dejavniki, ki so povezani z zdravljenjem (to so indirektna hiperbilirubinemija, znižan albumin) in niso nujno povezani z jetrno dekompenzacijo.
English: ● if you are a man who is taking Pegasys in combination with ribavirin, do not have sex with a pregnant woman unless you use a condom.
Slovenian: • Če ste moški in jemljete zdravilo Pegasys v kombinaciji z ribavirinom, ne smete imeti spolnega odnosa z nosečnico, razen če uporabite kondom.
English: In patients co-infected with HIV-HCV, limited efficacy and safety data are available in patients with CD4 counts less than 200 cells/µl.
Slovenian: Pri bolnikih, okuženih s HIV in HCV, so na voljo le omejeni podatki o učinkovitosti in varnosti pri bolnikih, ki imajo število celic CD4+ nižje od 200 celic/μl.
English: The first phase of decline occurs 24 to 36 hours after the first dose of Pegasys and is followed by the second phase of decline which continues over the next 4 to 16 weeks in patients who achieve a sustained response.
Slovenian: Prva faza zmanjšanja koncentracij se pojavi v 24 do 36 urah po prvem odmerku zdravila Pegasys, druga faza zmanjšanja koncentracij pa se pojavi v naslednjih 4 do 16 tednih zdravljenja pri bolnikih, ki dosežejo trajni odziv.
English: Patients who withdrew from previous therapy with pegylated interferon alfa-2b/ribavirin because of haematological toxicity were excluded from enrolling in this trial.
Slovenian: Bolniki, ki so prejšnje zdravljenje s pegiliranim interferonom alfa-2b/ribavirinom prekinili zaradi hematološke toksičnosti, niso bili vključeni v to preskušanje.
English: Differences in sustained virological response (SVR) based on treatment duration, demographics and best responses to previous treatment are displayed in Table
Slovenian: Razlike v trajnem virološkem odzivu glede na trajanje zdravljenja, demografijo in najboljši odziv na prejšnje zdravljenje so prikazane v preglednici 19.
English: Both chronic hepatitis B and C are viral infections of the liver.
Slovenian: Kronični hepatitis C in B sta virusni okužbi jeter.
English: a Patients who achieved viral suppression (undetectable HCV RNA, < 50 IU/ml) at week 12 were considered to have a virological response at week 12.
Slovenian: Za bolnike, ki so dosegli virusno supresijo (nemerljiva koncentracija HCV RNA, < 50 i.e./ml) v 12. tednu, so smatrali, da imajo virološki odziv v 12. tednu.
English: Pegasys contains benzyl alcohol.
Slovenian: Zdravilo Pegasys vsebuje benzilalkohol.
English: ● if you are coinfected with HIV and treated with anti HIV medicinal products.
Slovenian: • če ste okuženi z virusom HIV in se zdravite z zdravili, ki se uporabljajo pri zdravljenju okužbe s HIV,
English: In both studies, Pegasys apparent clearance and apparent volume of distribution were related linearly to body size ie. either BSA (NR16141) or body weight (YV25718).
Slovenian: V obeh študijah sta bila navidezni očistek in navidezni volumen porazdelitve zdravila Pegasys linearno povezana z velikostjo telesa, tj. telesno površino (NR16141) ali telesno maso (YV25718).
English: ● Pull the needle straight out of the skin.
Slovenian: ● Iglo iz kože potegnite naravnost.
English: Therefore, the combination of Pegasys with telbivudine is contraindicated.
Slovenian: Zato je kombinacija zdravila Pegasys in telbivudina kontraindicirana.
English: If symptoms of psychiatric disorders appear, the potential seriousness of these undesirable effects must be borne in mind by the prescribing physician and the need for adequate therapeutic management should be considered.
Slovenian: Če se simptomi psihiatričnih motenj pojavijo, mora lečeči zdravnik upoštevati možnost, da so ti neželeni učinki lahko resni in da bolnik lahko potrebuje ustrezno terapevtsko obravnavo.
English: Injury or poisoning: Substance overdose
Slovenian: Poškodbe ali zastrupitve: preveliko odmerjanje učinkovine.
English: Lactic acidosis and worsening liver function are side effects associated with Highly Active Anti-Retroviral Therapy (HAART), an HIV treatment.
Slovenian: Laktacidoza in poslabšanje delovanja jeter sta neželena učinka, ki sta povezana z visoko aktivno protiretrovirusno terapijo (HAART- »Highly Active Anti-Retroviral Therapy«) in zdravljenjem HIV.
English: Tell your doctor or pharmacist if you are being treated with telbivudine.
Slovenian: Obvestite svojega zdravnika ali farmacevta, če se zdravite s telbivudinom.
English: Study NV17317
Slovenian: Študija NV17317
English: This means that Pegasys is injected with a short needle into the fatty tissue under the skin in the abdomen or thigh.
Slovenian: To pomeni, da zdravilo Pegasys injiciramo s kratko iglo v maščobno tkivo pod kožo v predelu trebuha ali stegna.
English: Haemoglobin - stable cardiac disease decrease ≥ 2 g/dl during any 4 weeks
Slovenian: - stabilno srčno obolenje zmanjšanje za ≥ 2 g/dl v 4 tednih
English: The non-clinical toxicity studies conducted with Pegasys were limited due to species specificity of interferons.
Slovenian: Predklinične študije toksičnosti, ki so jih opravili z zdravilom Pegasys, so bile omejene zaradi specifičnosti interferonov pri posameznih vrstah.
English: ● if you are a woman of childbearing potential who is taking Pegasys in combination with ribavirin, you must have a negative pregnancy test before treatment, each month during therapy and for the 4 months after treatment is stopped.
Slovenian: • Če ste ženska v rodni dobi in jemljete zdravilo Pegasys v kombinaciji z ribavirinom, mora biti vaš test nosečnosti pred začetkom zdravljenja, vsak mesec med zdravljenjem in 4 mesece po končanem zdravljenju negativen.
English: Seven patients receiving combination Pegasys and ribavirin treatment for 48 weeks discontinued therapy for safety reasons (depression, psychiatric evaluation abnormal, transient blindness, retinal exudates, hyperglycaemia, type 1 diabetes mellitus, and anaemia).
Slovenian: Sedem bolnikov, ki je zdravljenje s kombinacijo zdravila Pegasys in ribavirina prejemalo 48 tednov, je prekinilo zdravljenje iz varnostnih razlogov (depresije, nenormalne psihiatrične ocene, prehodne slepote, retinalnih eksudatov, hiperglikemije, sladkorne bolezni tipa 1 in anemije).