FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors.
Danish: Patienter som tidligere har haft bronchospasmer, akut rhinitis, nasale polypper, angioneurotisk ødem, urticaria eller anden type allergisk reaktion efter at have taget acetylsalicylsyre eller NSAIDherunder COX-2 (cyclooxygenase-2) hæmmere.
English: There were no statistically significant differences in thrombotic event rates between etoricoxib and diclofenac across all subgroups analyzed including patient categories across a range of baseline cardiovascular risk.
Danish: Der var ingen statistisk signifikante forskelle i hyppigheden af thrombotiske hændelser mellem etoricoxib og diclofenac på tværs af alle analyserede undergrupper, inklusive patientkategorier på tværs af en række baseline kardiovaskulære risici.
English: Selective COX-2 inhibitors reduce the formation of systemic (and therefore possibly endothelial) prostacyclin without affecting platelet thromboxane.
Danish: Selektive COX-2 hæmmere reducerer dannelsen af systemiske (og dermed muligvis endotelderiveret) prostacyclin uden at påvirke thromboxan i blodpladerne.
English: • salbutamol tablets or oral solution (a medicine for asthma)
Danish: • Salbutamol-tabletter eller -opløsning (mod astma).
English: The rate per hundred patient-years was 0.22 on etoricoxib and 1.84 for diclofenac (p-value was <0.001 for etoricoxib vs. diclofenac).
Danish: Hyppigheden pr. hundrede patientår var 0,22 for etoricoxib og 1,84 for diclofenac (p-værdien var <0,001 for etoricoxib versus diclofenac).
English: How to store <ARCOXIA> Further information
Danish: Sådan opbevarer De ARCOXIA Yderligere oplysninger
English: Digoxin: Etoricoxib 120 mg administered once daily for 10 days to healthy volunteers did not alter the steady-state plasma AUC0-24hr or renal elimination of digoxin.
Danish: Digoxin: Etoricoxib 120 mg, administreret én gang dagligt i 10 dage til raske frivillige, ændrede ikke steady-state plasma AUC0-24t eller renal elimination af digoxin.
English: Estimated renal creatinine clearance <30 ml/min.
Danish: Anslået creatininclearance < 30 ml/min.
English: These increases in estrogenic concentration should be taken into consideration when selecting post-menopausal hormone therapy for use with etoricoxib because the increase in oestrogen exposure might increase the risk of adverse events associated with HRT.
Danish: Stigningerne i østrogenkoncentrationen skal tages med i overvejelserne, når der vælges et hormon til post-menopausal substitutionsterapi til brug samtidig med etoricoxib, fordi brug af en øget østrogenmængde kan øge risikoen for bivirkninger forbundet med hormonsubstitutionsbehandling.
English: WHAT <ARCOXIA> IS AND WHAT IT IS USED FOR
Danish: ARCOXIAS VIRKNING OG HVAD DE SKAL BRUGE DET TIL
English: • digoxin (a medicine for heart failure and irregular heart rhythm)
Danish: • Digoxin (mod hjertesygdom og forstyrrelser i hjerterytmen).
English: This leaflet was last approved in (MM/YYYY).
Danish: Denne indlægsseddel blev senest godkendt MM/ÅÅÅÅ
English: The difference in antiplatelet activity between some COX-1 inhibiting NSAIDs and selective COX-2 inhibitors may be of clinical significance in patients at risk of thrombo-embolic events.
Danish: Forskellen i antitrombocytaktivitet mellem COX-1-hæmmende NSAID og selektive COX-2-hæmmere kan være af klinisk betydning for patienter med risiko for udvikling af thromboemboliske hændelser.
English: 60 mg - 90 mg -120mg 2 Film coated tablets 5 Film-coated tablets 7 Film-coated tablets 10 Film-coated tablets 14 Film-coated tablets 20 Film-coated tablets 28 Film-coated tablets 30 Film-coated tablets 50 Film-coated tablets 84 Film-coated tablets 98 Film-coated tablets 100 Film-coated tablets 50 Film-coated tablets (unit dose) 100 Film-coated tablets (unit dose) 30 Film-coated tablets (HDPE bottles) 90 Film-coated tablets (HDPE bottles)
Danish: 60 mg - 90 mg - 120 mg 2 filmovertrukne tabletter 5 filmovertrukne tabletter 7 filmovertrukne tabletter 10 filmovertrukne tabletter 14 filmovertrukne tabletter 20 filmovertrukne tabletter 28 filmovertrukne tabletter 30 filmovertrukne tabletter 50 filmovertrukne tabletter 84 filmovertrukne tabletter 98 filmovertrukne tabletter 100 filmovertrukne tabletter 50 filmovertrukne tabletter (enkeltdosis) 100 filmovertrukne tabletter (enkeltdosis) 30 filmovertrukne tabletter (HDPE-flasker) 90 filmovertrukne tabletter (HDPE-flasker)
English: If you are currently taking low-dose aspirin to prevent heart attacks or stroke, you should not stop taking aspirin until you talk to your doctor
Danish: Hvis De er i behandling med lavdosis acetylsalicylsyre til forebyggelse af hjerteanfald eller slagtilfælde, bør De ikke stoppe med medicinen uden at rådføre Dem med Deres læge.
English: Patients with a recent history of myocardial infarction, coronary artery bypass grafting or percutaneous coronary intervention within 6 months preceding enrollment were excluded.
Danish: Patienter med nylig myokardieinfarkt i anamnesen, patienter der havde fået koronar bypass-operation eller fået foretaget perkutan koronarintervention inden for 6 måneder før inklusion, blev ekskluderet.
English: Hepatobiliary disorders: Very rare: hepatitis.
Danish: Lever og galdeveje: Meget sjælden: Hepatitis.
English: Clinical trials suggest that the selective COX-2 inhibitor class of drugs may be associated with a risk of thrombotic events (especially myocardial infarction (MI) and stroke), relative to placebo and some NSAIDs.
Danish: Kliniske undersøgelser tyder på, at gruppen af selektive COX-2 hæmmere kan være forbundet med risiko for thrombotiske hændelser (specielt myokardieinfarkt (MI) og apopleksi) i forhold til placebo og nogle NSAID.
English: Caution should be exercised when co-administering etoricoxib with warfarin or other oral anticoagulants (see section 4.5).
Danish: Der bør udvises forsigtighed, når etoricoxib administreres samtidig med warfarin eller andre orale antikoagulantia (se pkt.
English: It is advisable to rehydrate patients prior to starting therapy with etoricoxib.
Danish: Det tilrådes at rehydrere patienterne, inden etoricoxib-behandling påbegyndes.
English: • minoxidil (a drug used to treat high blood pressure)
Danish: • Minoxidil (mod forhøjet blodtryk).
English: For the subset of upper GI hemorrhage events (complicated and uncomplicated combined), there was no significant difference between etoricoxib and diclofenac.
Danish: For undergruppen af øvre GI-blødningshændelser (komplicerede og ukomplicerede samlet) var der ingen signifikant forskel mellem etoricoxib og diclofenac.
English: • You are dehydrated, for example by a prolonged bout of vomiting or diarrhoea.
Danish: • De lider af væskemangel, f.eks. på grund af anfald af opkastning eller diarré gennem længere tid.
English: If a woman becomes pregnant during treatment, etoricoxib must be discontinued.
Danish: Hvis graviditet forekommer under behandling, bør etoricoxib seponeres.
English: • methotrexate (a drug used for suppressing the immune system, and often used in rheumatoid arthritis)
Danish: • Methotrexat (et immunhæmmende lægemiddel, der ofte anvendes ved leddegigt).
English: However, patients at high risk of digoxin toxicity should be monitored for this when etoricoxib and digoxin are administered concomitantly.
Danish: Monitorering bør dog foretages hos patienter med høj risiko for digoxintoksicitet ved samtidig administration af etoricoxib og digoxin.
English: The effects of etoricoxib 120 mg on the exposure (AUC0-24hr) to these estrogenic components of PREMARIN were less than half of those observed when PREMARIN was administered alone and the dose was increased from 0.625 to 1.25 mg.
Danish: Effekten af etoricoxib 120 mg (AUC0-24t) sammen med Premarins østrogene komponenter var mindre end halvdelen af den observerede effekt, når Premarin blev givet alene, og dosis blev øget fra 0,625 mg til 1,25 mg.
English: In this trial, only serious adverse events and discontinuations due to any adverse events were recorded.
Danish: Der blev kun registreret alvorlige bivirkninger og seponering på grund af bivirkninger.
English: People with liver problems
Danish: Patienter med leverproblemer
English: In clinical trials, etoricoxib was evaluated for safety in 7152 individuals, including 4614 patients with OA, RA, chronic low back pain or ankylosing spondylitis (approximately 600 patients with OA or RA were treated for one year or longer).
Danish: Etoricoxib er i kliniske undersøgelser vurderet med hensyn til sikkerhed hos 7152 patienter, inklusive 4614 patienter med OA, RA, kroniske lændesmerter eller ankylosis spondylitis (ca. 600 patienter med OA eller RA blev behandlet i 1 år eller mere).
English: Hemodialysis contributed negligibly to elimination (dialysis clearance approximately 50 ml/min).
Danish: Hæmodialysen bidrog i negligiabel grad til eliminiation (dialyseclearance ca. 50 ml/min) (se pkt.
English: • if your doctor has diagnosed heart problems including heart failure (moderate or severe types), angina (chest pain) or if you have had a heart attack, bypass surgery, peripheral arterial disease (poor circulation in legs or feet due to narrow or blocked arteries), or any kind of stroke (including ministroke, transient ischaemic attack or TIA).
Danish: • hvis Deres læge har konstateret hjerteproblemer hos Dem, herunder nedsat hjertefunktion (moderat til svær), angina (brystsmerter), eller hvis De har haft et hjertetilfælde, har fået by-pass operation, har perifer arteriel sygdom (dårligt blodomløb i ben eller fødder på grund af snævre eller blokerede blodårer), eller anden form for slagtilfælde (herunder kortere varighed af mangel på blodtilførsel til hjernen, forbigående iskæmisk anfald).
English: 30 mg: lactose 1.4 mg 60 mg: lactose 2.8 mg 90 mg: lactose 4.2 mg 120 mg: lactose 5.6 mg
Danish: 30 mg: 1,4 mg lactose 60 mg: 2,8 mg lactose 90 mg: 4,2 mg lactose 120 mg: 5,6 mg lactose
English: Patients appear to be at highest risk for these reactions early in the course of therapy with the onset of the reaction occurring in the majority of cases within the first month of treatment.
Danish: Patienterne synes at have størst risiko for udvikling af disse reaktioner tidligt i behandlingsforløbet.
English: In some patients with compromised renal function (e.g. dehydrated patients or elderly patients with compromised renal function) the co-administration of an ACE inhibitor or Angiotensin II antagonist and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Danish: Hos nogle patienter med kompromitteret nyrefunktion (f.eks. dehydrerede eller ældre patienter med kompromitteret nyrefunktion), kan samtidig administration af ACE-hæmmere eller angiotensin-II-receptorantagonister og stoffer, der hæmmer cyclooxygenasen, medføre yderligere forværring af nyrefunktionen, inklusive mulig akut nyresvigt.
English: Always take <ARCOXIA> exactly as your doctor has told you.
Danish: Tag altid ARCOXIA nøjagtigt efter lægens anvisning.
English: Active peptic ulceration or active gastro-intestinal (GI) bleeding.
Danish: 6.1).Aktivt peptisk ulcus eller gastrointestinal (GI) blødning.
English: CV mortality, as well as overall mortality, was similar between the etoricoxib and diclofenac treatment groups.
Danish: Kardiovaskulær mortalitet og samlet mortalitet var den samme i etoricoxib- og diclofenacbehandlingsgrupperne.
English: The EDGE and EDGE II studies compared the gastrointestinal tolerability of etoricoxib versus diclofenac.
Danish: EDGE- og EDGE II-undersøgelserne sammenlignede den gastrointestinale tolerance over for etoricoxib mod diclofenac.
English: The rates of discontinuations due to adverse clinical GI events per hundred patient-years over the entire period of study were as follows: 3.23 for etoricoxib and 4.96 for diclofenac in the MEDAL Study; 9.12 with etoricoxib and 12.28 with diclofenac in the EDGE study; and 3.71 with etoricoxib and 4.81 with diclofenac in the EDGE II study.
Danish: Hyppigheden af seponering på grund af kliniske GI-hændelser pr. hundrede patientår i løbet af hele undersøgelsesperioden var: 3,23 for etoricoxib og 4,96 for diclofenac i MEDAL-undersøgelsen; 9,12 for etoricoxib og 12,28 for diclofenac i EDGE-undersøgelsen; og 3,71 for etoricoxib og 4,81 for diclofenac i EDGE II-undersøgelsen.
English: • You have swelling due to fluid retention.
Danish: • De har hævelser på grund af væskeophobning.
English: Ankylosing spondylitis is an inflammatory disease of the spine and large joints.
Danish: Ankyloserende spondylitis er en sygdom med betændelse i rygsøjlen og store led.
English: If you develop any of these signs you should stop <ARCOXIA> and talk to your doctor immediately:
Danish: Hvis De får et eller flere af disse symptomer, skal De stoppe med at tage ARCOXIA og straks kontakte lægen:
English: Some selective COX2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy.
Danish: Nogle selektive COX-2 hæmmere er blevet sat i forbindelse med øget risiko for hudreaktioner hos patienter med enhver form for lægemiddelallergi i anamnesen.
English: The main pathway of etoricoxib metabolism is dependent on CYP enzymes.
Danish: Etoricoxibs primære metaboliseringsvej er afhængig af CYP-enzymer.
English: Etoricoxib is contra-indicated in children and adolescents under 16 years of age (see section 4.3).
Danish: Børn: Etoricoxib er kontraindiceret til børn og unge under 16 år (se pkt.
English: Pregnancy and breast-feeding <ARCOXIA> tablets must not be taken during pregnancy.
Danish: ARCOXIA-tabletter må ikke tages under graviditet.
English: Immune system disorder:
Danish: Immunsystemet:
English: Etoricoxib should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
Danish: Behandlingen med etoricoxib bør seponeres ved den første forekomst af hududslæt, slimhindeaffektioner eller andre tegn på overfølsomhed.
English: Therefore:
Danish: Ud fra følgende betragtninger:
English: Paediatric patients: The pharmacokinetics of etoricoxib in paediatric patients (<12 years old) have not been studied.
Danish: Børn: Etoricoxibs farmakokinetik hos børn (< 12 år) er ikke undersøgt.
English: Nervous system disorder:
Danish: Nervesystemet:
English: * Based on analyses of long-term placebo and active controlled clinical trials, selective COX-2 inhibitors have been associated with an increased risk of serious thrombotic arterial events, including myocardial infarction and stroke.
Danish: Baseret på analyser af kontrollerede kliniske langtidsundersøgelser med placebo og lægemidler, er selektive COX-2 hæmmere blevet sat i forbindelse med en øget risiko for alvorlige arterielle thrombotiske hændelser, inklusive myokardieinfarkt og stroke.
English: These led to updates of the product information to include class warnings on the risk of CV thrombotic, GI and severe skin reactions with COX-2 selective inhibitors.
Danish: Disse indbringelser resulterede i opdateringer af produktoplysningerne, så disse kom til at omfatte lægemiddelgruppeadvarsler om risikoen for kardiovaskulære tromboemboliske reaktioner, gastrointestinale reaktioner og alvorlige hudreaktioner i forbindelse med brug af selektive COX-2-hæmmere.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT 30 Film coated tablets (HDPE bottles)
Danish: INDHOLDSMÆNGDE ANGIVET SOM VÆGT, VOLUMEN ELLER ANTAL DOSER 30 filmovertrukne tabletter (HDPE-flasker)
English: Methotrexate: Two studies investigated the effects of etoricoxib 60, 90 or 120 mg administered once daily for seven days in patients receiving once-weekly methotrexate doses of 7.5 to 20 mg for rheumatoid arthritis.
Danish: Methotrexat: Der er udført 2 undersøgelser af effekten af etoricoxib 60, 90 og 120 mg, administreret 1 gang dagligt i 7 dage til patienter, der fik methotrexat 1 gang ugentligt i doser på 7,5-20 mg for rheumatoid arthritis.
English: Oral anticoagulants: In subjects stabilised on chronic warfarin therapy, the administration of etoricoxib 120 mg daily was associated with an approximate 13% increase in prothrombin time International Normalised Ratio (INR).
Danish: Orale antikoagulantia: Hos patienter stabiliseret på kronisk warfarinbehandling var administration af etoricoxib 120 mg dagligt associeret med ca. 13% stigning i protrombin-tid (International Normalised Ratio, INR).
English: • shortness of breath, chest pains, or ankle swelling appear or if they get worse
Danish: • kortåndethed, brystsmerter, hvis anklerne hæver, eller hvis nogle af disse symptomer bliver værre
English: There is no clinical experience in patients with severe hepatic dysfunction (Child-Pugh score ≥10); therefore, its use is contra-indicated in these patients (see sections 4.3, 4.4 and 5.2).
Danish: Der er ingen klinisk erfaring hos patienter med svær leverdysfunktion (Child-Pugh score ≥10), derfor er brug hos disse patienter kontraindiceret (se pkt.
English: Ketoconazole: Ketoconazole, a potent inhibitor of CYP3A4, dosed at 400 mg once a day for 11 days to healthy volunteers, did not have any clinically important effect on the single-dose pharmacokinetics of 60 mg etoricoxib (43% increase in AUC).
Danish: Ketoconazol: Når ketoconazol, der er en potent hæmmer af CYP3A4, blev givet i doser à 400 mg én gang dagligt i 11 dage til raske frivillige, havde det ingen klinisk relevant effekt på farmakokinetikken for etoricoxib 60 mg én gang dagligt (43% stigning af AUC).
English: Adequate monitoring for methotrexate-related toxicity is recommended when etoricoxib and methotrexate are administered concomitantly.
Danish: Det anbefales at monitorere for methotrexat-relateret toksicitet, når etoricoxib administreres samtidig med methotrexat.
English: The rate of confirmed thrombotic cardiovascular serious adverse events (consisting of cardiac, cerebrovascular, and peripheral vascular events) was comparable between etoricoxib and diclofenac, and data are summarized in the table below.
Danish: Hyppigheden af bekræftede thrombotiske kardiovaskulære bivirkninger (omfattende kardielle, cerebrovaskulære og perifere vaskulære hændelser) var sammenlignelig mellem etoricoxib og diclofenac, og data er opsummeret i tabellen nedenfor.
English: Infections and infestations: Uncommon: gastroenteritis, upper respiratory infection, urinary tract infection.
Danish: Infektioner og parasitære sygdomme: Ikke-almindelig: Gastroenteritis, øvre luftvejsinfektion, urinvejsinfektion.
English: Eye disorders: Uncommon: blurred vision, conjunctivitis.
Danish: Øjne: Ikke almindelig: Sløret syn, conjunctivitis.
English: • if you are allergic to non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin and COX-2 inhibitors (see Possible Side Effects, section 4)
Danish: • hvis De er overfølsom over for nonsteroide antiinflammatoriske lægemidler (NSAID), herunder acetylsalicylsyre og COX-2-hæmmere (se Bivirkninger, pkt.
English: • ciclosporin or tacrolimus (drugs used for suppressing the immune system)
Danish: • Ciclosporin eller tacrolimus (immunhæmmende lægemidler).
English: The 30-, 60- and 120-mg tablets also contain indigo carmine lake (E132) and yellow ferric oxide (E172).
Danish: 30, 60 mg og 120 mg tabletten indeholder endvidere indigo carmine lake (E132) og gul jernoxid (E172).
English: Renal insufficiency: The pharmacokinetics of a single dose of etoricoxib 120 mg in patients with moderate to severe renal insufficiency and patients with end-stage renal disease on hemodialysis were not significantly different from those in healthy subjects.
Danish: Nyreinsufficiens: Farmakokinetikken i forbindelse med enkeltdosis etoricoxib 120 mg hos patienter med moderat til svær nyreinsufficiens og patienter med nyresygdom i terminalt stadie i hæmodialyse, var ikke signifikant forskellig fra den hos raske frivillige.
English: In vitro studies indicate that CYP2D6, CYP2C9, CYP1A2 and CYP2C19 also can catalyse the main metabolic pathway, but their quantitative roles in vivo have not been studied.
Danish: In vitro-undersøgelser indikerer, at CYP2D6, CYP2C9, CYP1A2 og CYP2C19 også kan katalysere den primære metaboliseringsvej, men deres kvantitative roller in vivo er ikke undersøgt.
English: Serious hypersensitivity reactions (such as anaphylaxis and angioedema) have been reported in patients receiving etoricoxib (see section 4.8).
Danish: Der er indberettet alvorlige hypersensitivitetsreaktioner (såsom anafylakse og angioødem) hos patienter, som fik etoricoxib (se pkt.
English: Core:
Danish: Hjerte:
English: Uncommon: atrial fibrillation, congestive heart failure, non-specific ECG changes, myocardial infarction
Danish: Ikke almindelig: Atrieflimren, venstresidig hjerteinsufficiens, uspecifikke EKG-forandringer, myokardieinfarkt
English: In a study in healthy subjects, daily administration of etoricoxib 120 mg did not alter hepatic CYP3A4 activity as assessed by the erythromycin breath test.
Danish: I en undersøgelse med raske frivillige ændrede daglig administration af etoricoxib 120 mg ikke hepatisk CYP3A4-aktivitet, vurderet ved erythromycin-pustetest.
English: - In view of the available data, the CHMP considered that the benefit/risk balance for Arcoxia (etoricoxib) 90mg dose in AS indication is positive; however, revisions to the contraindications and warnings sections have been added to the summary of product characteristics and package leaflet in relation to cardiorenal safety.
Danish: - På grundlag af de tilgængelige data anser CHMP, at benefit/risk-forholdet for Arcoxia (etoricoxib) 90 mg til indikationen AS er gunstigt, men i forbindelse med den kardiorenale sikkerhed er produktresuméets og indlægssedlens afsnit om kontraindikationer og advarsler blevet revideret anbefalede CHMP godkendelse af ændringen af markedsføringstilladelserne.
English: A significantly lower rate of discontinuations of treatment for any clinical (e.g., dyspepsia, abdominal pain, ulcer) GI adverse event was observed with etoricoxib compared with diclofenac within each of the three component studies of the MEDAL Program.
Danish: Der blev observeret en signifikant lavere hyppighed af seponering for kliniske GI-hændelser (bl.a. dyspepsi, abdominalsmerter, mavesår) med etoricoxib sammenlignet med diclofenac inden for hver af de tre komponentundersøgelser i MEDAL-programmet.
English: In two 12-week double-blind endoscopy studies, the cumulative incidence of gastroduodenal ulceration was significantly lower in patients treated with etoricoxib 120 mg once daily than in patients treated with either naproxen 500 mg twice daily or ibuprofen 800 mg three times daily.
Danish: I 2, 12-ugers, dobbeltblinde endoskopiundersøgelser, var den kumulative incidens af gastroduodenal ulceration signifikant lavere hos de patienter, der blev behandlet med etoricoxib 120 mg én gang dagligt, end hos de patienter, der blev behandlet med enten naproxen 500 mg 2 gange dagligt eller ibuprofen 800 mg 3 gange dagligt.
English: Etoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor within the clinical dose range.
Danish: Etoricoxib er inden for det kliniske dosisområde en oral, aktiv, selektiv cyclo-oxygenase-2 (COX-2) hæmmer.
English: The rate for confirmed upper GI events in elderly patients was evaluated and the largest reduction was observed in patients ≥ 75 years of age (1.35 [95% CI 0.94, 1.87] vs. 2.78 [95% CI 2.14, 3.56] events per hundred patient-years for etoricoxib and diclofenac, respectively.
Danish: Hyppigheden af bekræftede øvre GI-hændelser hos ældre patienter blev vurderet, og den største reduktion blev observeret hos patienter ≥ 75 år (1,35 [95 % konfidensinterval 0,94; 1,87] versus 2,78 [95 % konfidensinterval 2,14; 3,56]) hændelser pr. hundrede patientår for henholdsvis etoricoxib og diclofenac.
English: Gout is a disease of sudden, recurring attacks of very painful inflammation and redness in the joints.
Danish: Urinsyregigt er en lidelse, der er kendetegnet ved pludselige, tilbagevendende anfald af meget smertefuld gigt, som kan føre til hævelser og betændelse.