FrancophonIA/ELRC3.0 huggingface dataset:
English: The most effective method of removing lactate and metformin is haemodialysis.
Croatian: Najučinkovitija metoda uklanjanja laktata i metformina je hemodijaliza.
English: - metformin belongs to a group of medicines called biguanides which also help to lower blood sugar by lowering the amount of sugar made in the liver and helping insulin to work more effectively.
Croatian: - metformin pripada skupini lijekova pod nazivom bigvanidi i također pomaže sniziti šećer u krvi smanjujući količinu šećera što se stvara u jetri i pomažući inzulinu da učinkovitije djeluje.
English: You should not use Vipdomet if you are pregnant.
Croatian: Ne smijete uzimati Vipdomet ako ste trudni.
English: Alogliptin exists predominantly as the (R)-enantiomer (>99%) and undergoes little or no chiral conversion in vivo to the (S)-enantiomer.
Croatian: In vivo alogliptin postoji predominantno kao (R)-enantiomer (>99%) i malo se ili nimalo ne konvertira u kiralni (S)-enantiomer.
English: This has been shown at therapeutic doses in controlled, medium-term or long-term clinical studies; metformin reduces total cholesterol, LDL cholesterol and triglyceride levels.
Croatian: To je dokazano pri terapijskim dozama u kontroliranim kliničkim ispitivanjima srednjeg i dugog trajanja; metformin smanjuje ukupni kolesterol, LDL kolesterol i razine triglicerida.
English: Alogliptin is a potent and highly selective inhibitor of DPP-4, >10,000-fold more selective for DPP-4 than other related enzymes including DPP-8 and DPP-9.
Croatian: Alogliptin je potentan i visoko selektivan inhibitor DPP-4, s >10 000 puta većom selektivnošću za DPP-4 nego za druge srodne enzime, uključujući DPP-8 i DPP-9.
English: No data are available (see section 4.2 and above).
Croatian: Nema dostupnih podataka (vidjeti dio 4.2 i gore).
English: Factors that may increase the risk of lactic acidosis (see section 4.4) should be reviewed before considering initiation of metformin in patients with GFR<60 mL/min.
Croatian: Čimbenike koji mogu povećati rizik od laktacidoze (vidjeti dio 4.4) potrebno je provjeriti prije nego što se počne razmatrati uvođenje metformina u bolesnika s GFR<60 ml/min.
English: Preclinical data for metformin reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction.
Croatian: Pretklinički podaci o metforminu ne ukazuju na posebnu opasnost za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksikologije ponovljenih doza, genotoksičnosti, karcinogenog potencijala i reproduktivne toksičnosti.
English: Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption and appears generally to be without clinical significance.
Croatian: Dugotrajno liječenje metforminom bilo je povezano sa smanjenom apsorpcijom vitamina B12 za koju se općenito čini da je bez kliničkog značaja.
English: The blood peak is lower than the plasma peak and appears at approximately the same time.
Croatian: Vršna koncentracija u krvi je niža od vršne koncentracije u plazmi i čini se da se postižu istovremeno.
English: Very rare: - Decreased vitamin B12 levels or anaemia; symptoms include tiredness, lethargy, feeling faint,
Croatian: Vrlo rijetke: - Manjak vitamina B12 ili anemija; simptomi uključuju umor, bezvoljnost, osjećaj nesvjestice,
English: In case of dehydration (severe diarrhoea or vomiting, fever, heat, reduced fluid intake) Vipdomet should be temporarily discontinued and contact with a health care professional is recommended.
Croatian: U slučaju dehidracije (teški proljev ili povraćanje, vrućica ili smanjen unos tekućine), potrebno je privremeno prekinuti primjenu Vipdomet i preporučuje se obratiti se zdravstvenom radniku.
English: The efficacy and safety of the recommended doses of alogliptin and metformin in a subgroup of patients with type 2 diabetes mellitus and ≥65 years old were reviewed and found to be consistent with the profile obtained in patients <65 years old.
Croatian: Djelotvornost i sigurnost preporučenih doza alogliptina i metformina u podskupini bolesnika sa šećernom bolešću tipa 2 u dobi od ≥65 godina starosti su procijenjene i nađeno je da odgovaraju profilu dobivenom u bolesnika <65 godina starosti.
English: Vipdomet should not be used during pregnancy.
Croatian: Vipdomet se ne smije primjenjivati tijekom trudnoće.
English: In controlled clinical studies, maximum metformin plasma levels (Cmax) did not exceed 4 microgram/mL even at maximum doses.
Croatian: U kontroliranim kliničkim ispitivanjima najviše razine metformina u plazmi (Cmax) nisu prelazile 4 µg/ml, čak i pri najvišim dozama.
English: Insulin is known to cause hypoglycaemia.
Croatian: Poznato je da inzulin uzrokuje hipoglikemiju.
English: Stop taking Vipdomet for a short time if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal.
Croatian: Prestanite nakratko uzimati Vipdomet ako imate stanje koje može biti povezano s dehidracijom (značajan gubitak tjelesnih tekućina) kao što je jako povraćanje, proljev, vrućica, izloženost toplini ili ako pijete manje tekućine nego obično.
English: The (S)-enantiomer is not detectable at therapeutic doses.
Croatian: (S)-enantiomer nije nađen u terapijskim dozama.
English: In these studies, 696 alogliptin/metformin-treated patients were ≥ 65 years old.
Croatian: U tim je ispitivanjima 696 bolesnika liječenih alogliptinom/metforminom bilo u dobi od ≥65 godina starosti.
English: If you have reduced kidney function, your doctor may prescribe a lower dose, which may need to be given as separate tablets of alogliptin and metformin.
Croatian: Ako imate smanjenu funkciju bubrega liječnik Vam može propisati nižu dozu, koju ćete možda morati uzimati kao zasebne tablete alogliptina i metformina.
English: Microcrystalline cellulose Povidone K30
Croatian: Celuloza, mikrokristalična Povidon K30
English: Minimal to mild simple transitional cell hyperplasia was seen in the urinary bladder of male rats at the lowest dose used (27 times the human exposure) without establishment of a clear NOEL (no observed effect level).
Croatian: Minimalna do blaga jednostavna hiperplazija tranzicijskih stanica viđena je u mokraćnom mjehuru muških štakora, kod najmanje primijenjene doze (27 puta veća u odnosu na izloženost kod ljudi) bez jasno utvrđene razine bez opaženog štetnog učinka (NOEL).
English: Higher doses of alogliptin were not teratogenic but resulted in maternal toxicity, and were associated with delayed and/or lack of ossification of bones and decreased foetal body weights.
Croatian: Više doze alogliptina nisu bile teratogene, ali su izazvale toksičnost u majke te su bile povezane s odgođenim i/ili nedovoljnim okoštavanjem kostiju i smanjenim fetalnim težinama.
English: Patients (≥65 years old) with type 2 diabetes mellitus are considered more susceptible to episodes of hypoglycaemia than patients <65 years old.
Croatian: Bolesnici (≥65 godina starosti) sa šećernom bolešću tipa 2 smatraju se podložnijima epizodama hipoglikemije nego bolesnici <65 godina starosti.
English: Avoid excessive alcohol intake while taking Vipdomet since this may increase the risk of lactic acidosis - see section “Warnings and precautions”.
Croatian: Izbjegavajte prekomjerni unos alkohola dok uzimate lijek Vipdomet jer to može povećati rizik od laktacidoze (vidjeti dio “Upozorenja i mjere opreza”).
English: Vipdomet should be taken twice daily because of the pharmacokinetics of its metformin component.
Croatian: Vipdomet treba uzimati dvaput na dan zbog farmakokinetike metformina kojeg sadrži.
English: A study conducted in seven normal healthy volunteers showed that cimetidine (400 mg twice daily) increased metformin systemic exposure (area under the curve, AUC) by 50% and Cmax by 81%.
Croatian: Ispitivanje provedeno na sedam zdravih dobrovoljaca pokazalo je da je cimetidin (400 mg dvaput na dan) povećao sistemsku izloženost metforminu (površina ispod krivulje, AUC) za 50% i Cmax za 81%.
English: Alogliptin is primarily excreted unchanged in the urine and metabolism by the cytochrome (CYP) P450 enzyme system is negligible (see section 5.2).
Croatian: Alogliptin se prvenstveno izlučuje nepromijenjen u mokraći, a metabolizam putem enzimatskog sustava citokroma (CYP) P450 mu je zanemariv (vidjeti dio 5.2).
English: Renal clearance of metformin is >400 mL/min indicating that metformin is eliminated by glomerular filtration and tubular secretion.
Croatian: Bubrežni klirens metformina je >400 ml/min, što ukazuje da se metformin eliminira glomerularnom filtracijom i tubularnom sekrecijom.
English: Medicinal products with intrinsic hyperglycaemic activity Glucocorticoids (given by systemic and local routes), beta-2-agonists and diuretics (see also section 4.4) have intrinsic hyperglycaemic activity.
Croatian: Lijekovi s intrinzičnom hiperglikemijskom aktivnošću Glukokortikoidi (primijenjeni sistemskim ili lokalnim putem), beta-2-agonisti i diuretici (vidi također dio 4.4) imaju intrinzičku hiperglikemijsku aktivnost.
English: Total exposure (AUC(0-inf)) to alogliptin following administration of a single dose was similar to exposure during one dose interval (AUC(0-24)) after 6 days of once daily dosing.
Croatian: Ukupna izloženost (AUC(0-inf)) alogliptinu nakon primjene jednokratne doze bila je slična izloženosti nakon intervala od 6 dana primjene jedanput na dan (AUC(0-24)).
English: After an oral dose of metformin, the maximum plasma concentration (Cmax) is reached in approximately 2.5 hours (Tmax).
Croatian: Nakon primjene peroralne doze metformina najveća koncentracija u plazmi (Cmax) se postiže nakon približno 2,5 sata (tmax).
English: Very rare (may affect up to 1 in 10,000 people): - Lactic acidosis (a build-up of lactic acid in the blood) is a very serious side effect that may lead to coma.
Croatian: Vrlo rijetke (može se javiti u do 1 na 10 000 osoba): - Laktacidoza (nakupljanje mliječne kiseline u krvi) je vrlo ozbiljna nuspojava koja može izazvati komu.
English: It does not stimulate insulin secretion and, therefore, does not produce hypoglycaemia.
Croatian: Ne potiče lučenje inzulina i stoga ne dovodi do hipoglikemije.
English: Studies in lactating rats indicate that alogliptin is excreted in milk.
Croatian: Ispitivanja u štakorica u laktaciji pokazuju da se alogliptin izlučuje u mlijeko.
English: Administration of Vipdomet with food resulted in no change in total exposure (AUC) to alogliptin or metformin.
Croatian: Primjenom Vipdometa s hranom nije bilo promjene u ukupnoj izloženosti (AUC) alogliptinu ili metforminu.
English: Maximum daily dose is 12.5 mg
Croatian: Maksimalna dnevna doza iznosi 12,5 mg.
English: Evaluation should include serum electrolytes and ketones, blood glucose and, if indicated, blood pH, lactate, pyruvate and metformin levels.
Croatian: Pretrage trebaju uključivati elektrolite u serumu i ketone, glukozu u krvi i, ako je indicirano, pH krvi, te razine laktata, piruvata i metformina.
English: Metformin is contraindicated in patients with GFR<30 mL/min and should be temporarily discontinued in the presence of conditions that alter renal function (see section 4.3).
Croatian: Metformin je kontraindiciran u bolesnika s GFR<30 ml/min i njegovu je primjenu potrebno privremeno prekinuti ako su prisutna stanja koja mijenjaju funkciju bubrega (vidjeti dio 4.3).
English: Taking Vipdomet in combination with medicines called pioglitazone or insulin can cause too low blood sugar levels (hypoglycaemia), which may affect your ability to drive and use machines.
Croatian: Uzimanje Vipdometa u kombinaciji s pioglitazonom ili inzulinom može uzrokovati pretjerano nizak šećer u krvi (hipoglikemija), što može utjecati na sposobnost upravljanja vozilima i strojevima.
English: The study demonstrated that alogliptin did not increase the risk of having a MACE compared to placebo [Hazard Ratio: 0.96; 1-sided 99% Confidence Interval: 0-1.16].
Croatian: Ispitivanje je pokazalo da alogliptin nije povećao rizik za MACE u usporedbi s placebom [omjer hazarda: 0,96; 1-strano 99% Interval pouzdanosti: 0-1,16].
English: Common (may affect up to 1 in 10 people): - Symptoms of low blood sugar (hypoglycaemia) may occur when Vipdomet is taken in combination with insulin or sulphonylureas (e.g. glipizide, tolbutamide, glibenclamide).
Croatian: Česte (mogu se pojaviti kod do 1 od 10 osoba): - Simptomi niskog šećera u krvi (hipoglikemija) mogu se javiti kada se Vipdomet uzima u kombinaciji s inzulinom ili sulfonilurejama (npr. glipizid, tolbutamid, glibenklamid).
English: Interactions with metformin
Croatian: Interakcije s metforminom
English: Vipdomet is indicated in the treatment of adult patients aged 18 years and older with type 2 diabetes mellitus:
Croatian: Vipdomet je indiciran za liječenje odraslih bolesnika u dobi od 18 godina i starijih sa šećernom bolešću tipa 2:
English: If you need to have major surgery you must stop taking Vipdomet during and for some time before and after the procedure.
Croatian: Ako se morate podvrgnuti velikom kirurškom zahvatu, morate prestati uzimati lijek Vipdomet tijekom i još neko vrijeme nakon zahvata.
English: - Severe and persistent pain in the abdomen (stomach area) which might reach through to your back as well as nausea and vomiting, as it could be a sign of an inflamed pancreas (pancreatitis).
Croatian: - Jaka i ustrajna bol u trbuhu (u području želuca) koja može sezati do leđa, kao i mučnina i povraćanje, što može biti znak upale gušterače (pankreatitis).
English: The pharmacokinetics of alogliptin has been shown to be similar in healthy subjects and in patients with type 2 diabetes mellitus.
Croatian: Pokazalo se da je farmakokinetika alogliptina slična kod zdravih ispitanika i bolesnika sa šećernom bolešću tipa 2.
English: There was no change in the time to peak plasma concentration (Tmax) for alogliptin, but there was a delayed Tmax for metformin of 1.5 hours.
Croatian: Nije bilo promjene u vremenu do vršne koncentracije u plazmi (tmax) za alogliptin, ali tmax za metformin bio je odgođen za 1,5 sat.
English: If acidosis of either form occurs, Vipdomet must be stopped immediately and other appropriate corrective measures initiated.
Croatian: Ako se u bilo kojem obliku pojavi acidoza, Vipdomet treba odmah prekinuti i poduzeti odgovarajuće mjere liječenja radi korekcije.
English: Maximum daily dose The maximum recommended daily dose of 25 mg alogliptin should not be exceeded.
Croatian: Maksimalna dnevna doza Maksimalna preporučena dnevna doza od 25 mg alogliptina se ne smije prekoračiti.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Vipdomet in all subsets of the paediatric population in the treatment of type 2 diabetes mellitus (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Vipdomet u jednoj ili više podskupinama pedijatrijske populacije za liječenje šećerne bolesti tipa 2 (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: As Vipdomet contains metformin, any patient with type 2 diabetes mellitus previously well controlled on Vipdomet who develops laboratory abnormalities or clinical illness (especially vague and poorly defined illness) should be evaluated promptly for evidence of ketoacidosis or lactic acidosis.
Croatian: Budući da Vipdomet sadrži metformin, kod svih bolesnika sa šećernom bolešću tipa 2 koji su ranije bili dobro kontrolirani lijekom Vipdomet, a u kojih se razviju abnormalnosti u laboratorijskim nalazima ili klinička bolest (posebice nejasna i loše definirana bolest), treba odmah ispitati dokaze na ketoacidozu ili laktacidozu.
English: What Vipdomet contains - The active substances are alogliptin and metformin hydrochloride.
Croatian: Što Vipdomet sadrži - Djelatne tvari su alogliptin i metforminklorid.
English: DPP-4 is the principal enzyme involved in the rapid degradation of the incretin hormones, glucagon-like peptide-1 (GLP-1) and GIP (glucose-dependent insulinotropic polypeptide), which are released by the intestine and levels are increased in response to a meal.
Croatian: DPP-4 je glavni enzim uključen u brzu razgradnju inkretinskih hormona, glukagonu sličnog peptida-1 (GLP-1) i GIP (inzulinotropnog polipeptida ovisnog o glukozi), koji se izlučuju u crijevu i razine su im povišene kao odgovor na obrok.
English: Maximum daily dose is 3,000 mg Dose reduction may be considered in relation to declining renal function.
Croatian: Maksimalna dnevna doza je 3000 mg Može se razmotriti sniženje doze s obzirom na slabljenje funkcije bubrega.
English: In the alogliptin group, 12.7% (344 subjects) experienced an event within the secondary MACE composite endpoint, compared with 13.4% (359 subjects) in the placebo group [Hazard Ratio = 0.95; 1-sided 99% Confidence Interval: 0-1.14].
Croatian: U skupini na alogliptinu, 12,7% (344 ispitanika) imalo je događaj unutar sekundarnog MACE kompozitnog ishoda, u usporedbi s 13,4% (359 ispitanika) u skupini na placebu [omjer hazarda = 0,95; 1-strano 99% Interval pouzdanosti: 0-1,14].
English: However, dosing of alogliptin should be conservative in patients with advanced age due to the potential for decreased renal function in this population
Croatian: Međutim, u bolesnika uznapredovale dobi doziranje alogliptina treba biti konzervativno zbog moguće smanjene funkcije bubrega u toj populaciji.
English: It should also be taken with meals to reduce the gastrointestinal adverse reactions associated with metformin.
Croatian: Također ga treba uzimati uz obroke kako bi se smanjile gastrointestinalne nuspojave povezane s metforminom.
English: Alogliptin has not been studied in patients with severe hepatic impairment (Child-Pugh score >9).
Croatian: Alogliptin nije ispitan u bolesnika sa teškim oštećenjem jetre (Child-Pugh indeks >9).
English: Special caution should be exercised in situations where renal function may become impaired, for example when initiating antihypertensive or diuretic therapy or when starting treatment with a nonsteroidal anti-inflammatory drug (NSAID).
Croatian: Poseban oprez nužan je u okolnostima kad bi funkcija bubrega mogla postati poremećena, na primjer kad se započinje terapija antihipertenzivima ili diureticima ili kad se započinje liječenje nesteroidnim protuupalnim lijekovima (NSAIL).
English: Alogliptin works to increase the levels of insulin in the body after a meal and decrease the amount of sugar in the body.
Croatian: Alogliptin djeluje tako da podiže razine inzulina u tijelu nakon obroka i smanjuje količinu šećera u krvi.
English: Stop taking Vipdomet and contact a doctor or the nearest hospital immediately if you experience some of the symptoms of lactic acidosis, as this condition may lead to coma.
Croatian: Prestanite uzimati Vipdomet i odmah se obratite liječniku ili otiđite u najbližu bolnicu ako osjetite neke od simptoma laktacidoze, jer to stanje može dovesti do kome.
English: Total and peak exposure to alogliptin increased proportionately across single doses of 6.25 mg up to 100 mg alogliptin (covering the therapeutic dose range).
Croatian: Ukupna i vršna izloženost alogliptinu se proporcionalno povećavala povišenjem jednokratnih doza od 6,25 mg do 100 mg alogliptina (što obuhvaća opseg terapijske doze).
English: Overall, treatment with the recommended total daily dose of 25 mg alogliptin in combination with metformin improved glycaemic control.
Croatian: Sveukupno, liječenje preporučenom ukupnom dnevnom dozom od 25 mg alogliptina u kombinaciji s metforminom poboljšalo je kontrolu glikemije.
English: Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose.
Croatian: Metformin je bigvanid s antihiperglikemijskim učincima koji smanjuje i bazalnu i postprandijalnu glukozu u plazmi.
English: No dose adjustment is necessary (see section 4.2).
Croatian: Nije potrebna prilagodba doze (vidjeti dio 4.2).
English: In a clinical trial of alogliptin as mono-therapy, the incidence of hypoglycaemia was similar to that of placebo, and lower than placebo in another trial as add-on to a sulphonylurea.
Croatian: U kliničkom ispitivanju alogliptina kao monoterapije, incidencija hipoglikemije bila je slična kao za placebo, odnosno niža nego za placebo u drugom ispitivanju alogliptina kao dodatka sulfonilureji.
English: Maximum daily dose is 2,000 mg The starting dose is at most half of the maximum dose.
Croatian: Maksimalna dnevna doza je 2000 mg Početna doza iznosi najviše polovicu maksimalne doze.
English: It is assumed that the pharmacokinetics of metformin absorption is non-linear.
Croatian: Pretpostavlja se da je farmakokinetika metformina nelinearna.
English: However, as the distribution of AUC values for alogliptin in these patients was within the same range as control subjects, no dose adjustment of alogliptin for patients with mild renal impairment is necessary (see section 4.2).
Croatian: Međutim, kako je distribucija AUC vrijednosti za alogliptin u tih bolesnika bila unutar istog raspona kao i u kontrolnih ispitanika, prilagodba doze alogliptina u bolesnika s blagim oštećenjem bubrega nije potrebna (vidjeti dio 4.2).
English: crospovidone Type A, magnesium stearate, hypromellose, talc, titanium dioxide (E171) and yellow iron oxide (E172).
Croatian: magnezijev stearat, hipromeloza, talk, titanijev dioksid (E171) i žuti željezov oksid (E172).
English: Concomitant treatment with alogliptin and metformin did not produce new toxicities and no effects on the toxicokinetics of either compound were observed.
Croatian: Istodobna primjena alogliptina i metformina ne izaziva nove toksičnosti niti su opaženi učinci na toksikokinetiku bilo koje od djelatnih tvari.
English: Lactic acidosis is a serious adverse reaction, which may occur very rarely (<1/10,000), and is attributed to the metformin component of Vipdomet (see section 4.4).
Croatian: Laktacidoza je ozbiljna nuspojava koja se može javiti vrlo rijetko (<1/10 000) i pripisuje se komponenti metformina u Vipdometu (vidjeti dio 4.4).
English: Vipdomet should not be used in patients with type 1 diabetes mellitus.
Croatian: Vipdomet se ne smije primjenjivati u bolesnika sa šećernom bolešću tipa 1.
English: In case of hypoglycaemia, a lower dose of the thiazolidinedione or metformin may be considered.
Croatian: U slučaju hipoglikemije, potrebno je razmotriti nižu dozu tiazolidindiona ili metformina.
English: Vipdomet has no or negligible influence on the ability to drive and use machines.
Croatian: Vipdomet ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Vipdomet is taken when your blood sugar cannot be adequately controlled by diet, exercise and other anti-diabetic medicines such as metformin alone; insulin alone; or metformin and pioglitazone taken together.
Croatian: Vipdomet se uzima kad se Vaš šećer u krvi ne može odgovarajuće kontrolirati dijetom, tjelovježbom i drugim antidijabetičkim lijekovima poput samog metformina, samog inzulina, ili metformina i pioglitazona uzetih zajedno.
English: 10 film-coated tablets 14 film-coated tablets 20 film-coated tablets 28 film-coated tablets 56 film-coated tablets 60 film-coated tablets 98 film-coated tablets 112 film-coated tablets 120 film-coated tablets 180 film-coated tablets 196 film-coated tablets 200 film-coated tablets
Croatian: 10 filmom obloženih tableta 14 filmom obloženih tableta 20 filmom obloženih tableta 28 filmom obloženih tableta 56 filmom obloženih tableta 60 filmom obloženih tableta 98 filmom obloženih tableta 112 filmom obloženih tableta 120 filmom obloženih tableta 180 filmom obloženih tableta 196 filmom obloženih tableta 200 filmom obloženih tableta
English: If you stop taking Vipdomet
Croatian: Ako prestanete uzimati Vipdomet
English: Pack sizes of 10, 14, 20, 28, 56, 60, 98, 112, 120, 180, 196, 200 or multipacks containing 196 (2 packs of 98) film-coated tablets.
Croatian: Veličine pakiranja od 10, 14, 20, 28, 56, 60, 98, 112, 120, 180, 196, 196, 200 ili višestruka pakiranja koja sadrže 196 (2 pakiranja po 98) filmom obloženih tableta.