FrancophonIA/ELRC3.0 huggingface dataset:
English: Other key symptoms include gastrointestinal, respiratory or constitutional symptoms such as lethargy and malaise.
Slovenian: Ostali ključni simptomi vključujejo prebavne, dihalne ali konstitucionalne simptome kot sta letargija in splošno slabo počutje.
English: Abacavir: AUC ↑41% Ethanol: AUC ↔
Slovenian: abakavir: AUC ↑41% etanol: AUC ↔
English: Patients should be advised that Kivexa or any other antiretroviral therapy does not cure HIV infection and that they may still develop opportunistic infections and other complications of HIV infection.
Slovenian: Bolnikom je potrebno pojasniti, da zdravilo Kivexa ali katero koli drugo protiretrovirusno zdravilo okužbe z virusom HIV ne ozdravi in da se tako še vedno lahko pojavijo oportunistične okužbe in drugi zapleti, vezani na okužbo z virusom HIV.
English: Rare: Rises in serum amylase.
Slovenian: Redki: povečane vrednosti serumske amilaze.
English: When concomitant administration with co-trimoxazole is warranted, patients should be monitored clinically.
Slovenian: Če je potrebna sočasna uporaba kotrimoksazola, je treba bolnike klinično kontrolirati.
English: Tell your doctor if you are being treated with any of these.
Slovenian: Povejte svojemu zdravniku, če se zdravite s katerimkoli od teh zdravil.
English: HSRs have been observed with abacavir, some of which have been life-threatening, and in rare cases fatal, when not managed appropriately.
Slovenian: Med uporabo abakavirja so opažali HSR; nekatere od njih so bile življenjsko nevarne in v primeru neustreznega vodenja v redkih primerih smrtne.
English: For many of these adverse reactions it is unclear whether they are related to the active substance, the wide range of other medicinal products used in the management of HIV infection, or whether they are a result of the underlying disease process.
Slovenian: Za mnoge od teh neželenih učinkov ni povsem jasno, če so povezani z zdravilno učinkovino, s katerim izmed številnih drugih zdravil, ki se uporabljajo pri zdravljenju okužbe z virusom HIV, ali so posledica samega osnovnega bolezenskega procesa.
English: Proposed actions: Provision of updated ABC HSR education materials for healthcare professionals to countries where the MAH has marketing authorisation for ABC.
Slovenian: Predlagani ukrepi: Zagotovitev posodobljenih izobraževalnih gradiv o preobčutljivostnih reakcijah na ABC za zdravnike v državah, v katerih ima imetnik dovoljenja za promet dovoljenje za promet z ABC.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Slovenian: Od zdravstvenih delavcev se zahteva, da poročajo o katerem koli domnevnem neželenem učinku zdravila na nacionalni center za poročanje, ki je naveden v .
English: • phenytoin, for treating epilepsy.
Slovenian: • fenitoin za zdravljenje epilepsije;
English: If overdose occurs the patient should be monitored for evidence of toxicity (see section 4.8), and standard supportive treatment applied as necessary.
Slovenian: V primeru zaužitja prevelikega odmerka je potrebno pri bolniku redno preverjati znake toksičnosti (glejte poglavje 4.8) ter po potrebi pričeti s standardnim podpornim zdravljenjem.
English: Tell your doctor if you are taking methadone.
Slovenian: Zdravniku morate povedati, če jemljete metadon.
English: It is recommended that HIV infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.
Slovenian: Zato je priporočljivo, da matere, ki so okužene z virusom HIV, v nobenem primeru ne dojijo dojenčkov in se tako izognejo možnosti za prenos virusa HIV.
English: Symptoms usually include fever, plus some of the following:
Slovenian: Med simptomi so po navadi povišana telesna temperatura in še nekaj od naslednjega:
English: If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered.
Slovenian: Če se pri teh bolnikih opazi poslabšanje bolezni jeter, je potrebno razmisliti o začasni prekinitvi ali trajni ukinitvi zdravljenja.
English: This indicates a low likelihood for interactions with other medicinal products through plasma protein binding displacement.
Slovenian: To kaže na majhno verjetnost interakcij z drugimi zdravili zaradi izpodrivanja vezave na plazemskih proteinih.
English: If you notice any of these symptoms contact a doctor urgently.
Slovenian: Če opazite katerega od teh simptomov, se morate nujno posvetovati z zdravnikom.
English: If you forget to take a dose, take it as soon as you remember.
Slovenian: Če ste pozabili vzeti zdravilo Kivexa Če ste pozabili vzeti odmerek, ga vzemite takoj, ko se spomnite.
English: The inclusion of zidovudine in the regimen has been found to reduce the frequency of L74V and K65R selection in the presence of abacavir (with zidovudine: 0/40, without zidovudine: 15/192, 8%).
Slovenian: Ugotovljeno je bilo, da vključitev zidovudina v režim zmanjša pogostnost selekcij L74V in K65R v prisotnosti abakavirja (z zidovudinom: 0/40, brez zidovudina: 15/192, 8 %).
English: Common: rash (without systemic symptoms) Very rare: erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis
Slovenian: Pogosti: eksantem (brez sistemskih simptomov) Zelo redki: multiformni eritem, Stevens-Johnsonov sindrom in toksična epidermalna nekroliza
English: Swallow the tablets whole, with some water.
Slovenian: je ena tableta na dan. Tablete zaužijte cele z nekaj vode.
English: When you are being treated for HIV, it can be hard to tell whether a symptom is a side effect of Kivexa or other medicines you are taking, or an effect of the HIV disease itself.
Slovenian: Med zdravljenjem okužbe s HIV je težko reči, ali je nek simptom neželen učinek zdravila Kivexa ali drugih zdravil, ki jih jemljete, ali pa je posledica same okužbe s HIV.
English: Since lamivudine is dialysable, continuous haemodialysis could be used in the treatment of overdose, although this has not been studied.
Slovenian: Ker se lamivudin dializira, bi se za odpravljanje posledic zaužitja prevelikega odmerka lahko poslužili kontinuirane hemodialize, vendar pa to ni bilo preučeno.
English: Hypersensitivity reactions can start at any time during treatment with Kivexa, but are more likely during the first 6 weeks of treatment.
Slovenian: Preobčutljivostne reakcije se lahko pojavijo kadarkoli med zdravljenjem z zdravilom Kivexa, a so verjetnejše v prvih 6 tednih zdravljenja.
English: Number of Subjects Number of Virological Failures Number of OnTherapy Genotypes
Slovenian: Število oseb Število virusnih neodzivov Število genotipov med zdravljenjem
English: Potential to slightly decrease abacavir plasma concentrations through UGT induction.
Slovenian: Obstaja možnost za rahlo znižanje plazemske koncetracije abakavirja preko indukcije UGT.
English: • aches and pains (especially in the hip, knee or shoulder)
Slovenian: • bolečine (zlasti v kolku, kolenu ali rami);
English: Symptoms usually appeared within the first six weeks (median time to onset 11 days) of initiation of treatment with abacavir, although these reactions may occur at any time during therapy.
Slovenian: Simptomi se običajno pojavijo v prvih šestih tednih (povprečen čas do pojava je 11 dni) po začetku zdravljenja z abakavirjem, vendar pa se lahko preobčutljivostne reakcije pojavijo kadar koli med zdravljenjem.
English: • HLA-B*5701 status must always be documented prior to initiating therapy.
Slovenian: • HLA-B*5701 status je vedno treba dokumentirati pred začetkom zdravljenja.
English: HLA-B*5701 is the only identified pharmacogenetic marker that is consistently associated with clinical diagnosis of an ABC HSR reaction.
Slovenian: HLA-B*5701 je edini ugotovljeni farmakogenetski označevalec, ki je dosledno povezan s klinično diagnozo preobčutljivostnih reakcij na ABC.
English: Abacavir increases the rate at which methadone is removed from the body.
Slovenian: Abakavir poveča hitrost odstranjevanja metadona iz telesa.
English: Due to similarities, Kivexa should not be administered concomitantly with other cytidine analogues, such as emtricitabine.
Slovenian: Zaradi podobnosti se zdravila Kivexa ne sme uporabljati sočasno z drugimi analogi citidina, npr. emtricitabinom.
English: Abbreviations: ↑ = Increase; ↓ = decrease; ↔ = no significant change; AUC = area under the concentration versus time curve; Cmax = maximum observed concentration; CL/F = apparent oral clearance
Slovenian: Okrajšave: ↑ = povečanje, ↓ = zmanjšanje, ↔ = ni pomembne spremembe, AUC = površina pod krivuljo koncentracije po času, Cmax = največja opažena koncentracija, CL/F = navidezni peroralni očistek Pediatrična populacija
English: Those studied were mainly antiretroviral experienced patients.
Slovenian: Bolniki, ki so bili vključeni v raziskavo, so večinoma že imeli izkušnje z antiretrovirusnimi zdravili.
English: Abacavir HSR has been well characterised through clinical studies and during post marketing follow-up.
Slovenian: HSR na abakavir so dobro opredelili v kliničnih študijah in med obdobjem spremljanja po prihodu zdravila na trg.
English: These hypersensitivity reactions have been seen more frequently in people taking medicines that contain abacavir.
Slovenian: Te preobčutljivostne reakcije so pogosteje opazili pri ljudjeh, ki so jemali zdravila, katera so vsebovala abakavir.
English: Almost all HSR to abacavir include fever and/or rash.
Slovenian: Skoraj vse HSR na abakavir vključujejo povišano telesno temperaturo in/ali izpuščaj.
English: People with advanced HIV infection (AIDS) have weak immune systems, and are more likely to develop serious infections (opportunistic infections).
Slovenian: Bolniki z napredovalo okužbo s HIV (aidsom) imajo oslabel imunski sistem, zato je pri njih večja verjetnost za nastanek hudih okužb (oportunističnih okužb).
English: There are no data available on the safety of abacavir and lamivudine when administered to babies less than three months old.
Slovenian: O varnosti abakavirja in lamivudina, uporabljenih pri dojenčkih, mlajših od treh mesecev, ni podatkov.
English: Kivexa should not be administered to children who weigh less than 25 kg because it is a fixed-dose tablet that cannot be dose reduced.
Slovenian: Zdravilo Kivexa se ne sme dajati otrokom, ki tehtajo manj kot 25 kg, saj gre za tableto s fiksnim odmerkom, ki se ga ne da zmanjševati.
English: Following multiple oral doses of abacavir 300 mg twice a day there is no significant accumulation of abacavir.
Slovenian: Po večkratnem peroralnem dajanju abakavirja v odmerku 300 mg dvakrat dnevno ne prihaja do pomembnega kopičenja abakavirja.
English: Very rare: Cases of peripheral neuropathy (or paraesthesia) have been reported
Slovenian: Zelo redki: poročali so o primerih periferne nevropatije (ali parestezije).
English: If ABC hypersensitivity cannot be ruled out on clinical grounds, ABC should be permanently discontinued and should not be restarted, regardless of the results of HLA-B*5701 screening.
Slovenian: Če preobčutljivosti na ABC na podlagi kliničnih ugotovitev ni mogoče izključiti, je treba ABC trajno prenehati uporabljati in se ga ne sme ponovno uvesti, ne glede na rezultate presejanja za HLA-B*5701.
English: Other signs and symptoms that have been observed as part of abacavir HSR are described in detail in section 4.8 (Description of selected adverse reactions), including respiratory and gastrointestinal symptoms.
Slovenian: Drugi znaki in simptomi, opaženi v okviru HSR na abakavir, so podrobno opisani v poglavju 4.8 (Opis izbranih neželenih učinkov), vključno z dihalnimi in prebavnimi simptomi.
English: Lamivudine was not teratogenic in animal studies but there were indications of an increase in early embryonic deaths in rabbits at relatively low systemic exposures, comparable to those achieved in humans.
Slovenian: V raziskavah na živalih lamivudin ni pokazal teratogenih učinkov, obstajajo pa indikacije za povečano embrionalno smrtnost kuncev, in to že pri relativno nizkih sistemskih izpostavljenostih, ki so primerljive s tistimi doseženimi pri ljudeh.
English: What you need to know before you take Kivexa
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Kivexa
English: Drug susceptibility scores were assigned for each patient's viral genotype utilising the ANRS 2009 HIV-1 genotypic drug resistance algorithm.
Slovenian: Ocene občutljivosti na zdravilo so bile določene za vsak bolnikov virusni genotip z uporabo algoritma ANRS 2009 genotipske odpornosti HIV-1 proti zdravilu.
English: The exception was the preputial gland tumour which occurred at a dose of 110 mg/kg in mice.
Slovenian: Izjema je bil tumor na prepucionalnih žlezah, ki se je pri miših pojavil pri odmerku 110 mg/kg/dan.
English: Four or more NRTIassociated mutations 28
Slovenian: Štiri ali več mutacij, povezanih z NRTI
English: Kivexa should not be taken with any other medicinal products containing lamivudine or medicinal products containing emtricitabine.
Slovenian: Zdravila Kivexa se ne sme jemati skupaj s katerimkoli zdravilom, ki vsebuje lamivudin ali z zdravilom, ki vsebuje emtricitabin.
English: Continued passage in increasing concentrations of drug resulted in selection for double RT mutants 65R/184V and 74V/184V or triple RT mutant 74V/115Y/184V.
Slovenian: Nadaljnji prehodi v naraščajočih koncentracijah zdravila so povzročili selekcijo za dvojna RT-mutanta 65R/184V in 74V/184V ali trojni RT-mutant 74V/115Y/184V.
English: Therapy should be prescribed by a physician experienced in the management of HIV infection.
Slovenian: Zdravljenje mora predpisati zdravnik, ki ima izkušnje z zdravljenjem okužb z virusom HIV.
English: • sensation of weakness in the limbs
Slovenian: • občutek šibkosti v udih;
English: Kivexa can be taken with or without food.
Slovenian: Zdravilo Kivexa se lahko jemlje s hrano ali brez nje.
English: Passage with a zidovudine resistant clinical isolate RTMC also selected for the 184V mutation.
Slovenian: Prehod s kliničnim izolatom RTMC, odpornim proti zidovudinu, je tudi povzročil selekcijo za mutacijo 184V.
English: No pharmacokinetic data are currently available in patients over 65 years of age.
Slovenian: Podatki o farmakokinetičnih lastnostih pri bolnikih, starejših od 65 let, trenutno niso na voljo.
English: Your doctor may advise you to stop taking Kivexa.
Slovenian: Zdravnik vam bo morda svetoval, da nehate jemati zdravilo Kivexa.
English: No clinical data are available in patients with moderate or severe hepatic impairment, therefore the use of Kivexa is not recommended unless judged necessary.
Slovenian: Pri bolnikih z zmerno ali hudo jetrno okvaro ni kliničnih podatkov, zato uporaba zdravila Kivexa ni priporočljiva, razen če je nujno potrebna.
English: Kivexa is not recommended in patients with moderate or severe hepatic impairment (see sections 4.2 and 5.2).
Slovenian: Zdravilo Kivexa se ne priporoča pri bolnikih z zmerno ali hudo jetrno okvaro (glejte poglavji 4.2 in 5.2).
English: • if their immune systems are very weak
Slovenian: • če imajo oslabel imunski sistem;
English: The EU RMP of the abacavir (ABC) containing products (Ziagen, Kivexa and Trizivir) includes the following risk minimisation plan in relation to abacavir hypersensitivitiy reaction (HSR), which is an important identified risk:
Slovenian: EU RMP za zdravila z abakavirjem (ABC) (Ziagen, Kivexa in Trizivir) vključuje naslednji načrt za zmanjšanje tveganj v zvezi s preobčutljivostnimi reakcijami na abakavir, ki so pomembno ugotovljeno tveganje: Skrbi glede varnosti
English: If you have stopped taking Kivexa If you have stopped taking Kivexa for any reason - especially because you think you are having side effects, or because you have other illness: Talk to your doctor before you start taking it again.
Slovenian: Če ste zdravilo Kivexa prenehali jemati zaradi kakršnegakoli razloga - še zlasti če menite, da imate neželene učinke, ali ker imate druge bolezni: se posvetujte s svojim zdravnikom, preden znova začnete jemati zdravilo.
English: Analysis of the data from subjects in the low viral load stratum showed no demonstrable difference between the nucleoside backbones in the proportion of patients free of virological failure at week 96.
Slovenian: Analiza podatkov bolnikov v stratumu z majhnim virusnim bremenom ni pokazala nobenih dokazljivih razlik med nukleozidnima osnovama, kar zadeva delež bolnikov brez neuspeha zdravljenja 96. teden.
English: Rash (usually maculopapular or urticarial)
Slovenian: Koža izpuščaj (običajno makulopapulozen ali urtikarijski)
English: Very rarely cases of erythema multiforme, Stevens-Johnson syndrome or toxic epidermal necrolysis have been reported where abacavir hypersensitivity could not be ruled out.
Slovenian: Poročali so o zelo redkih primerih multiformnega eritema, Stevens-Johnsonovega sindroma ali toksične epidermalne nekrolize, ko preobčutljivosti na abakavir ni bilo mogoče izključiti.
English: Do not stop taking Kivexa unless your doctor advises you to do so.
Slovenian: Ne nehajte jemati zdravila Kivexa, razen če vam to svetuje zdravnik.
English: Typically, such reactions have been observed within the first few weeks or months of initiation of CART.
Slovenian: Take reakcije so navadno opazili v prvih nekaj tednih ali mesecih po uvedbi kombiniranega protiretrovirusnega zdravljenja.
English: Abacavir and its metabolites are excreted into the milk of lactating rats.
Slovenian: Abakavir in njegovi presnovki se izločajo v mleko doječih podgan.
English: Some people taking medicines for HIV infection develop other conditions, which can be serious.
Slovenian: Nekaterim bolnikom, ki jemljejo zdravila za zdravljenje okužbe s HIV se pojavijo druge motnje, ki so lahko resne.
English: Abacavir + lamivudine + PI (or PI/ritonavir)
Slovenian: Abakavir + lamivudin + PI (ali PI/ritonavir)
English: Lamivudine-TP and carbovir-TP (the active triphosphate form of abacavir) are substrates for and competitive inhibitors of HIV reverse transcriptase (RT).
Slovenian: Lamivudin-TP in karbovir-TP (aktivna trifosfatna oblika abakavirja) sta substrata za reverzno transkriptazo (RT) virusa HIV in tudi njena kompetitivna inhibitorja.
English: Your doctor may need to monitor you while you are taking Kivexa.
Slovenian: Zdravnik vas bo morda moral med jemanjem zdravila Kivexa spremljati.
English: The presence of M184V with K65R does give rise to crossresistance between abacavir, tenofovir, didanosine and lamivudine, and M184V with L74V gives rise to cross-resistance between abacavir, didanosine and lamivudine.
Slovenian: Vendar prisotnost M184V s K65R povzroči navzkrižno odpornost med abakavirjem, tenofovirjem, didanozinom in lamivudinom ter prisotnost M184V z L74V povzroči navzkrižno odpornost med abakavirjem, didanozinom in lamivudinom.
English: Importantly, such symptoms may lead to misdiagnosis of HSR as respiratory disease (pneumonia, bronchitis, pharyngitis), or gastroenteritis.
Slovenian: Pomembno je, da lahko takšni simptomi povzročijo napačno prepoznavo HSR kot bolezni dihal (pljučnica, bronhitis, faringitis)
English: Excipient(s) with known effect: sunset yellow FCF (E110) 1.7 mg per tablet For the full list of excipients see section 6.1.
Slovenian: Pomožne snovi z znanim učinkom: sončno rumeno FCF (E110) 1,7 mg na tableto Za celoten seznam pomožnih snovi glejte poglavje 6.1.
English: Therefore patients should remain under close clinical observation by physicians experienced in the treatment of these associated HIV diseases.
Slovenian: Bolniki morajo ostati pod skrbnim kliničnim nadzorom zdravnikov z izkušnjami pri zdravljenju na okužbo z virusom HIV vezanih bolezni.
English: The active ingredients of Kivexa may inhibit cellular DNA replication and abacavir has been shown to be carcinogenic in animal models (see section 5.3).
Slovenian: Učinkovini zdravila Kivexa lahko inhibirata replikacijo celične DNK, in abakavir se je izkazal za mutagenega v študijah na živalskih modelih (glejte poglavje 5.3).
English: Similar reactions have also occurred infrequently after restarting abacavir in patients who had only one of the key symptoms of hypersensitivity (see above) prior to stopping abacavir; and on very rare occasions have also been seen in patients who have restarted therapy with no preceding symptoms of a HSR (i.e., patients previously considered to be abacavir tolerant).
Slovenian: Podobne reakcije so se v redkih primerih pojavile po ponovni uporabi abakavirja pri bolnikih, ki so imeli pred prenehanjem zdravljenja z abakavirjem le enega od ključnih simptomov preobčutljivosti (glejte zgoraj); v zelo redkih primerih so se pojavile celo pri bolnikih, ki so ponovno začeli zdravljenje, ne da bi pred tem imeli kakšne simptome HSR (tj. pri bolnikih, za katere je pred tem veljalo, da prenesejo abakavir).
English: NAME OF THE MARKETING AUTHORISATION HOLDER ViiV Healthcare BV
Slovenian: IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM ViiV Healthcare BV
English: The pharmacokinetics of abacavir in patients with end-stage renal disease is similar to patients with normal renal function.
Slovenian: Pri bolnikih s terminalnim stadijem ledvične bolezni je farmakokinetika abakavirja podobna kot pri bolnikih z normalnim ledvičnim delovanjem.
English: Orange, film-coated, modified capsule shaped tablets, debossed with GS FC2 on one side.
Slovenian: Oranžne filmsko obložene tablete v obliki modificirane kapsule, na eni strani označene z GS FC2.
English: In patients with mild hepatic impairment (Child-Pugh score 5-6) close monitoring is required, including monitoring of abacavir plasma levels if feasible (see sections 4.4 and 5.2).
Slovenian: Pri bolnikih z blago jetrno okvaro (Child-Pugh ocena 5-6) je potreben skrben nadzor, vključno z nadziranjem plazemske vrednosti abakavirja, če je to izvedljivo (glejte poglavji 4.4 in 5.2).
English: You should have been tested for this gene before Kivexa was prescribed for you.
Slovenian: Testiranje za ta gen ste morali opraviti, preden vam je zdravnik predpisal zdravilo Kivexa.
English: The systemic exposure at the no effect level in mice and rats was equivalent to 3 and 7 times the human systemic exposure during therapy.
Slovenian: Sistemska izpostavljenost, ki na miših in podganah ni imela še nobenega karcinogenega učinka, je bila ekvivalentna 3-kratni oziroma 7-kratni sistemski izpostavljenosti med zdravljenjem človeka.
English: Median Change vRNA (log10 c/mL)
Slovenian: Mediana sprememba vRNA (log10 kopij/ml)
English: After 36 weeks on a regimen including twice daily abacavir and lamivudine, 669 eligible subjects were randomised to either continue twice daily dosing or switch to once daily abacavir and lamivudine for at least an additional 96 weeks.
Slovenian: Po 36 tednih režima odmerjanja, ki je vključeval abakavir in lamivudin dvakrat na dan, so 669 primernih preiskovancev randomizirali bodisi na nadaljevanje uporabe dvakrat na dan bodisi na prehod na uporabo abakavirja in lamivudina enkrat na dan za vsaj dodatnih 96 tednov.
English: No pharmacokinetic data are available in patients over 65 years of age.
Slovenian: Za bolnike, starejše od 65 let, podatki o farmakokinetičnih lastnostih niso na voljo.
English: Kivexa is indicated in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infection in adults, adolescents and children weighing at least 25 kg (see sections 4.4 and 5.1).
Slovenian: Zdravilo Kivexa je indicirano pri kombiniranem protiretrovirusnem zdravljenju z virusom humane imunske pomanjkljivosti (HIV) okuženih odraslih, mladostnikov in otrok, ki tehtajo vsaj 25 kg (glejte poglavje 4.4 in 5.1).
English: However, as there were only moderately experienced patients included in this study with an imbalance in baseline viral load between the arms, these results should be interpreted with caution.
Slovenian: Vendar pa, ker so bili v to študijo vključeni le zmerno zdravljeni bolniki in ker izhodiščna obremenitev z virusom med skupinami ni bila enaka, je pri interpretaciji teh rezultatov potrebna previdnost.
English: If you have stopped taking Kivexa
Slovenian: Če ste prenehali jemati zdravilo Kivexa
English: Kivexa is a fixed-dose tablet and should not be prescribed for patients requiring dose adjustments.
Slovenian: Zdravilo Kivexa je v obliki tablet s fiksnim odmerkom in se ga ne sme predpisovati bolnikom, pri katerih je potrebno prilagajanje odmerjanja.