FrancophonIA/ELRC3.0 huggingface dataset:
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from chenodeoxycholic acid therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman
Slovenian: Odločiti se je treba bodisi za prenehanje dojenja ali za prekinitev/prenehanje zdravljenja s henodeoksiholno kislino, pri čemer se upošteva korist dojenja za otroka in korist zdravljenja za žensko.
English: In addition to sulfation, bile acid can also be detoxified through glucronidation.
Slovenian: Poleg sulfatiranja lahko žolčno kislino detoksificiramo tudi preko glucronidationa.
English: Women of childbearing potential should use an effective method of contraception.
Slovenian: Ženske v rodni dobi morajo uporabljati učinkovito metodo kontracepcije.
English: Rankin and EDSS scores remained stable in 61.5% and 50% of patients respectively, however there was an overall worsening of the mean score from baseline.
Slovenian: Rezultati Rankin in EDSS pri 61,5 % in 50 % bolnikih so ostali stabilni, vendar se je pojavilo splošno poslabšanje povprečne ocene od izhodišča.
English: The presented safety information for hepatic adverse reactions is derived from paediatric patients.
Slovenian: Predstavljeni varnostni podatki pri neželenih učinkih na jetra izhajajo iz pediatričnih bolnikov.
English: The safety and efficacy of Chenodeoxycholic acid Leadiant has not been studied in babies less than one month of age.
Slovenian: Dojenčki Varnost in učinkovitost henodeoksiholne kisline ni bila raziskana pri dojenčkih, mlajših od enega meseca starosti.
English: Size 0 capsule, 21.7 mm in length with a yellow body and orange cap, containing a white, compressed powder.
Slovenian: Kapsula velikosti 0, 21,7 mm v dolžino z rumenim telesom in oranžnim pokrovom, ki vsebuje bel, stisnjen prah.
English: In case of persistent lack of therapeutic response to chenodeoxycholic acid monotherapy, other treatment options should be considered.
Slovenian: V primeru vztrajnega pomanjkanja terapevtskega odziva na monoterapijo s henodeoksiholno kislino je treba razmisliti o drugih načinih zdravljenja.
English: Patients with CTX and high cholestanol have been shown to have adverse outcomes during pregnancy.
Slovenian: Pri bolnicah s CTX in visokim holestanolom so se pojavili negativni rezultati med nosečnostjo.
English: Study resultsPSUR and annual reassessments
Slovenian: Rezultati študijePSUR in ponovne letneocene
English: Diarrhoea improved or disappeared in 64.3% of the patients who had this symptom present at baseline.
Slovenian: Driska se je izboljšala ali izginila pri 64,3 % bolnikih s tem simptomom ob izhodišču.
English: Treatment must be initiated and monitored by physicians experienced in the management of CTX or inborn errors of primary bile acid synthesis.
Slovenian: Zdravljenje mora uvesti in nadzorovati zdravnik, ki ima izkušnje z obvladovanjem CTX ali prirojenih napak sinteze primarnih žolčnih kislin.
English: Maternal effects in the rhesus monkeys, but not baboons, included diarrhoea, emesis, weight loss and reduction in food consumption.
Slovenian: Učinki na mater pri rezus opicah, vendar ne pri pavijanih, so vključevali drisko, bruhanje, zmanjšanje telesne mase in zmanjšanje zaužite hrane.
English: The suspension is formed quite easily and is ready when there are no visible lumps or powder left.
Slovenian: Suspenzija se razmeroma lahko pripravi in je nared, ko v prahu ni več vidnih grudic.
English: Your doctor will advise you if for any reason you have to stop treatment with Chenodeoxycholic acid Leadiant.
Slovenian: Zdravnik vam bo svetoval, če morate iz kakršnega koli razloga prekiniti zdravljenje s henodeoksiholno kislino.
English: The daily dose can be subsequently increased in 250 mg increments to a maximum of 1000 mg/ day if the serum cholestanol and/or urine bile alcohols remain elevated.
Slovenian: Dnevni odmerek se lahko kasneje poveča v korakih po 250 mg na največ 1000 mg/dan, če vrednosti seruma holestanola in/ali žolčnih alkoholov v urinu ostanejo povišane.
English: Take your next dose when you would normally take it. Do not take a double dose to make up for a forgotten dose.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: The potential for harm from overdose is considered extremely low, as accumulation of chenodeoxycholic acid is unlikely due to an efficient endogenous mechanism of elimination and excretion.
Slovenian: Potencial za škodo zaradi prevelikega odmerka se šteje kot izjemno nizek, saj kopičenje henodeoksiholne kisline ni verjetno zaradi učinkovitega endogenega mehanizma izločanja.
English: Adverse reactions are ranked according to system organ class, using the following convention: very common (≥ 1/10), common (≥ 1/100 to <1/10), uncommon (≥ 1/1,000 to <1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Slovenian: pogosti (≥ 1/100 to <1/10), občasni (≥ 1/1.000 to <1/100), redki (≥ 1/10.000 do < 1/1000), zelo redki
English: Oral contraceptives are not recommended.
Slovenian: Peroralni kontraceptivi niso priporočljivi.
English: The starting dosage in adults is 750 mg/day, in three divided doses provided that it is sufficient to normalise serum cholestanol and/or urine bile alcohols.
Slovenian: Začetni odmerek za odrasle je 750 mg/dan, v treh deljenih odmerkih pod pogojem, da to zadostuje za normalizacijo seruma holestanola in/ali žolčnih alkoholov v urinu.
English: • medicines to treat heartburn (antacids) containing aluminium hydroxide and/or smectite
Slovenian: • zdravila za zdravljenje zgage (antacidi), ki vsebuje aluminijev hidroksid in/ali smektit
English: The capsules consist of a yellow body and an orange cap containing a white compressed powder.
Slovenian: Kapsule so sestavljene iz rumenega telesa in oranžne kapice, ki vsebuje stisnjen bel prašek.
English: For the other medicines in this list, take them either 2 hours before or 2 hours after taking Chenodeoxycholic acid Leadiant.
Slovenian: Za druga zdravila iz tega seznama velja, da jih vzemite 2 uri pred ali 2 uri po zaužitju zdravila Henodeoksiholna kislina Leadiant.
English: Women should use an effective contraceptive method whilst taking Chenodeoxycholic acid Leadiant.
Slovenian: Ženske morajo uporabljati učinkovito kontracepcijsko metodo, medtem ko jemljejo henodeoksiholno kislino.
English: The doctor should provide information on the dose to be received according to the weight of the child.
Slovenian: Zdravnik mora zagotoviti informacije o prejetem odmerku, glede na telesno maso otroka.
English: In patients with CTX, no interaction studies with chenodeoxycholic acid and concomitantly administered medicinal products have been performed.
Slovenian: Pri bolnikih z CTX niso izvedli nobenih študij medsebojnega delovanja s henodeoksiholno kislino in sočasno uporabljenimi zdravili.
English: It is recommended that this suspension is prepared by the pharmacy and instructions given to the parent on how to administer the suspension.
Slovenian: Priporočljivo je, da suspenzijo pripravi farmacevt, ki staršem posreduje navodila o odmerjanju suspenzije.
English: Chenodeoxycholic acid has no or negligible influence on the ability to drive and use machines.
Slovenian: Henodeoksiholna kislino nima ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: The starting dose in children is 5 mg/kg/day in three divided doses.
Slovenian: Začetni odmerek pri otrocih je 5 mg/kg/dan v treh deljenih odmerkih.
English: In the pivotal study CDCA-STUK-15-001 treatment of CTX patients with chenodeoxycholic acid 7501000 mg/day in adults or 5-15 mg/kg/day in infants and children was associated with statistically significant decreases in mean serum levels of cholestanol from baseline to post-baseline in the overall population and in the two subgroups of patients aged < 21 years or ≥ 21 years at first treatment.
Slovenian: V ključni študiji CDCA-STUK-15-001 je zdravljenje bolnikov s CTX z henodeoksiholno kislino z odmerkom 750-1000 mg/dan pri odraslih ali 5-15 mg/kg/dan pri dojenčkih in otrocih povezana s statistično pomembnim znižanjem povprečnega seruma holestanola od izhodišča do post-izhodišča v celotni populaciji in v dveh podskupinah bolnikov, starih <21 let ali ≥21 let na prvem zdravljenju.
English: Vitamin D and PTH levels decreased from baseline to both post-treatment visits and mean pyruvate levels decrease from baseline to the first post-treatment visit.
Slovenian: Ravni vitamina D in koncentracije PTH so se zmanjšale od izhodišča pri obeh naknadnih obiskih po zdravljenju in povprečne ravni piruvata so se znižale od izhodišča pri prvem obisku po zdravljenju.
English: Chenodeoxycholic acid Leadiant should be used under medical supervision.
Slovenian: Zdravilo Henodeoksiholinska kislina Leadiant je treba uporabljati pod zdravniškim nadzorom.
English: Chenodeoxycholic acid is not recommended during pregnancy and in women of childbearing potential not using contraception.
Slovenian: Uporaba henodeoksiholne kisline ni priporočena med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo kontracepcije.
English: None of the patients had treatment-related adverse events and chenodeoxycholic acid exhibited a satisfactory safety profile in relation to routine safety laboratory parameters (haematology and clinical chemistry).
Slovenian: Nobeden od bolnikov ni imel neželenih učinkov povezanih z zdravljenjem in henodeoksiholna kislina je imela zadovoljiv varnostni profil v povezavi z rutinskimi varnostnimi laboratorijskimi parametri
English: In contrast, Lithocholic acid sulfate conjugation in humans prevents the overt hepatotoxicity, as seen in animal toxicity species after repeat dosing.
Slovenian: V nasprotju s tem konjugacija sulfata litoholne kisline pri ljudeh preprečuje očitno hepatotoksičnost, kot je razvidno iz vrste toksičnosti na živalih po zdravljenju.
English: The starting dose will be calculated at 5 mg per kg per day.
Slovenian: Začetni odmerek se izračuna po 5 mg na kg na dan.
English: This instance of hepatic adverse reactions in an infant presented with multiple confounders, such as concomitant parechovirus infection, co-administration of medicinal products known to affect liver function (acyclovir and phenobarbital) and presence of hyperbilirubinemia at birth.
Slovenian: Ta primer neželenih učinkov na jetra pri dojenčku je bil prisoten s številnimi motečimi dejavniki, kot so sočasna okužba s parehovirusom, sočasna uporaba zdravil, ki vplivajo na delovanje jeter (aciklovir in fenobarbital) in prisotnost hiperbilirubinemije ob rojstvu.
English: Whereas 7-keto-lithocholic acid can be formed partially in the colon and also in the liver to chenodeoxycholic acid and ursodeoxycholic acid (3α-, 7ß-di-hydroxycholanic acid), lithocholic acid is absorbed to a small extent only and is thus largely lost with faeces.
Slovenian: Medtem ko se 7-keto litoholna kislina lahko v debelem črevesu in tudi v jetrih delno tvori v henodeoksiholno kislino in ursodeoksiholno kislino (3α-, 7β-di-hidroksiholanska kislina), se litoholna kislina absorbira le v majhni meri in se zato v veliki meri izgubi z blatom.
English: Ciclosporin and sirolimus
Slovenian: Ciklosporin in sirolimus
English: After reabsorption in the intestine, the bile acid is nearly completely conjugated to the amino acids glycine and taurine and then excreted again in the bile.
Slovenian: Po reabsorpciji v črevesju se žolčna kislina skoraj popolnoma združi v aminokislini glicin in tavrin in se nato ponovno izloči v žolč.
English: The mean levels of 7α-hydroxy-4-cholesten-3one significantly decreased from baseline to post-baseline Visits 1 and 2.
Slovenian: Povprečne ravni 7α-hidroksi-4holesten-3-on so se bistveno znižale od izhodiščne vrednosti, po začetku študije pri naknadnem prvem in drugem obisku.
English: Oral contraceptives may affect the way in which Chenodeoxycholic acid Leadiant works making it less effective.
Slovenian: Peroralni kontraceptivi lahko vplivajo na način delovanja zdravila Henodeoksiholna kislina Leadiant, zaradi česar je manj učinkovito.
English: Adverse reactions in patients (both adults and children) receiving Chenodeoxycholic acid are generally mild to moderate in severity; the main reactions observed are given in the table below.
Slovenian: Povzetek varnostnega profila Neželeni učinki pri bolnikih (tako odrasli in otroci), ki so prejemali henodeoksiholno kislino so na splošno blagi do zmerni; glavni opaženi učinki so navedeni v spodnji preglednici.
English: For infants and children who cannot swallow capsules, the capsules may be carefully opened and the content added to sodium bicarbonate solution 8.4%, see section 6.6.
Slovenian: Za dojenčke in otroke, ki ne morejo pogoltniti kapsul, lahko kapsule previdno odpremo in vsebino dodamo raztopini natrijevega bikarbonata 8,4%, glejte poglavje 6.6.
English: The infant's liver function normalised upon temporarily stopping treatment with Chenodeoxycholic acid.
Slovenian: Delovanje jeter dojenčka se je normalizirajo po začasni prekinitvi zdravljenja z henodeoksiholno kislino.
English: Deconjugation results in the free bile acid, oxidation in the 7-keto-lithocholic acid and lithocholic acid (3α-hydroxycholanic acid) is formed by elimination of the 7-hydroxy group.
Slovenian: Dekonjugacija vodi v prosto žolčno kislino, oksidacija v 7-keto-litoholno kislino in litoholna kislina (3α-hidroksiholanska kislina) se tvori z odcepitvijo 7-hidroksilne skupine.
English: Patients with a rare condition known as cerebrotendinous xanthomatosis (CTX) cannot produce chenodeoxycholic acid and this causes a buildup of fatty deposits in various areas of the body.
Slovenian: Bolniki z redko motnjo, znano kot cerebrotendinoznaksantomatoza (CTX) ne morejo proizvesti henodeoksiholne kisline, kar povzroča kopičenje maščobnih oblog na različnih delih telesa.
English: If it is necessary to take a medicinal product containing one of these active substances it should be taken either 2 hours before or after taking chenodeoxycholic acid.
Slovenian: Če morate vzeti zdravilo, ki vsebuje eno izmed teh učinkovin, jih je treba jemati bodisi 2 uri pred ali po jemanju henodeoksiholne kisline.
English: 100 hard capsules
Slovenian: 100 trdih kapsul
English: Chenodeoxycholic acid is an endogenous bile acid used for replacement therapy and it is anticipated to have no effects on fertility at therapeutic doses.
Slovenian: Henodeoksiholna kislina je endogena žolčna kislina, ki se uporablja za nadomestno zdravljenje in je pričakovati, da ne vpliva na plodnost pri terapevtskih odmerkih.
English: Rodent and primate toxicity species lack efficient-sulfating capacity for conjugation of lithocholic acid, and therefore have shown hepatotoxicity.
Slovenian: Toksičnost za glodalce in primate ima premalo sulfatne zmogljivosti za konjugacijo litoholne kisline, zato se je pojavila hepatotoksičnost.
English: Capsule contents: maize starch, magnesium stearate, silica colloidal anhydrous, water,
Slovenian: Vsebina kapsule: koruzni škrob, magnezijev stearat, koloidni brezvodni silicijev dioksid, , voda,
English: Ciclosporin has been shown to reduce the synthesis of chenodeoxycholic acid by inhibition of CYP27A1 and increasing the activity of HMG CoA reductase.
Slovenian: Za ciklosporin je dokazano, da zmanjša sintezo henodeoksiholne kisline z inhibicijo CYP27A1 in poveča aktivnost HMG CoA reduktaze.
English: In rhesus monkey and baboon studies it was demonstrated that chenodeoxycholic acid dose to pregnant animals (at 5-120 mg/kg/day for rhesus monkey; at 18-38 mg/kg/day for baboons) produced liver pathology in the developing foetus.
Slovenian: Študije z rezus opicami in pavijani so pokazale, da je odmerek henodeoksiholne kisline pri brejih živalih (pri odmerku 5-120 mg/kg/dan pri rezus opicah; pri odmerku 18-38 mg/kg/dan pri pavijanih) povzročil patologijo jeter pri razvijajočem zarodku.
English: Reduced production of cholesterol: reduces serum cholestanol (action on HMG CoA reductase).
Slovenian: Manjša produkcija holesterola: zmanjša serum holestanol (učinek na HMG CoA reduktazo).
English: A pharmacy label should be placed on the bottle and include the patient's name, dosing instructions, use by date, name of medicinal product and any other required information to be in compliance with local pharmacy regulations.
Slovenian: datum uporabe, ime zdravila, in vse druge potrebne informacije v skladu z lokalnimi predpisi v lekarni.
English: Chenodeoxycholic acid is indicated for the treatment of inborn errors of primary bile acid synthesis due to sterol 27 hydroxylase deficiency (presenting as cerebrotendinous xanthomatosis (CTX)) in infants, children and adolescents aged 1 month to 18 years and adults.
Slovenian: Henodeoksiholna kislina je indicirana za zdravljenje prirojenih napak sinteze primarnih žolčnih kislin zaradi pomanjkanja sterol 27-hidroksilaze (se kaže kot cerebrotendinozna ksantomatoza (CTX)) pri dojenčkih, otrocih in mladostnikih, starih od 1 meseca do 18 let in odraslih.
English: The lowest dose of chenodeoxycholic acid that effectively reduces the serum cholestanol and/or urine bile alcohols levels to within the normal range should be chosen.
Slovenian: Treba je izbrati najnižji odmerek henodeoksiholne kisline, ki učinkovito zmanjšuje ravni seruma holestanol in/ali ravni žolčnih alkoholov v urinu v mejah normale.
English: Reduced production of atypical bile alcohols and bile acids: through restoration of feedback inhibition of primary bile acid synthesis (action on CYP7A1)
Slovenian: Manjša produkcija atipičnih žolčnih alkoholov in žolčnih kislin: z obnavljanjem povratne inhibicije primarne sinteze žolčne kisline (učinek na CYP7A1).
English: If your doctor considers it necessary for you to take ciclosporin, sirolimus or phenobarbital they will closely monitor the results of blood and urine tests and adjust the dose of Chenodeoxycholic acid Leadiant if necessary.
Slovenian: Če zdravnik meni, da morate jemati ciklosporin, sirolimus ali fenobarbital, bo pozorno spremljal rezultate preiskav krvi in urina ter prilagodil odmerek henodeoksiholne kisline, če je potrebno.
English: In CTX, deficiency of chenodeoxycholic acid causes a lack of feedback of cholesterol 7 alpha hydroxylase (CYP7A1) and HMG CoA reductase, causing increased production of atypical bile acids, bile alcohols and cholestanol that lead to the pathological consequences of the condition.
Slovenian: Pri CTX, pomanjkanje henodeoksiholne kisline povzroča premajhno odzivnost holesterola 7-alfa hidroksilaze (CYP7A1) in HMG Co A reduktaze, kar povzroča povečano produkcijo netipičnih žolčnih kislin, žolčnih alkoholov in holestanola, ki vodijo do patoloških posledic.
English: Oral contraceptives therefore may worsen the underlying deficiency and counteract the effectiveness of chenodeoxycholic acid in CTX.
Slovenian: Peroralni kontraceptivi lahko zato poslabšajo prisotno pomanjkljivost in preprečijo učinkovitost henodeoksiholne kisline pri bolnikih s CTX.
English: MedDRA System Organ Class Preferred term
Slovenian: MedDRA podatkovna baza glede na organske sisteme prednostni izraz pogostost
English: Urinary bile level alcohol levels decreased.
Slovenian: Količina žolčnega alkohola v urinu se je znižala.
English: Increases in bone mineral density (Z-score) were observed at lumbar spine at both post-treatment visits and at total hip at post-treatment at post-treatment Visit 2.
Slovenian: (Z-score) ledvene hrbtenice so opazili pri obeh obiskih po zdravljenju in v celotnem kolku po zdravljenju na drugem obisku.
English: Dose calculation (Children 1-12yr, adolescents 12-18yr and adults) chenodeoxycholic acid 10 mg/mL suspension
Slovenian: Izračun odmerka (otroci 1-12 let, najstniki 12-18 let in odrasli) suspenzije henodeoksiholne kisline 10 mg/ml za bolnika
English: Two intrauterine deaths in a mother with CTX have been reported in the literature.
Slovenian: Literatura navaja dve intrauterini smrti pri materah s CTX.
English: The pharmacy should provide oral dose syringes of appropriate volume and grading for administering the suspension.
Slovenian: Lekarna vam mora zagotoviti brizge za peroralni odmerek z ustrezno prostornino in lestvico za odmerjanje suspenzije.
English: This being an approval under exceptional circumstances and pursuant to Article 14(8) of Regulation (EC) No 726/2004, the MAH shall conduct, within the stated timeframe, the following measures:
Slovenian: 726/2004, mora imetnik dovoljenja za promet v določenem časovnem okviru izvesti naslednje ukrepe:
English: Exogenous chenodeoxycholic acid is used as replacement therapy to restore the feedback inhibition lost due to the deficiency/absence of endogenous chenodeoxycholic acid.
Slovenian: Eksogena henodeoksiholna kislina se uporablja za nadomestno zdravljenje za obnavljanje povratne inhibicije, do katere je prišlo zaradi pomanjkanja/odsotnosti endogenske henodeoksiholne kisline.
English: The maximum dose for children is 15 mg per kg per day.
Slovenian: Največji odmerek za otroke je 15 mg na kg na dan.
English: Colestipol and antacid medicinal products
Slovenian: Holestipol in antacidi
English: During the initiation of therapy and dose adjustment, serum cholestanol levels and/or urine bile alcohols should be monitored every 3 months till metabolic control and then annually.
Slovenian: V začetku zdravljenja in po prilagoditvi odmerka je treba na vsake 3 mesece spremljati vrednosti seruma holestanola in/ali urina žolčnih alkoholov do presnovne urejenosti in nato vsako leto.
English: The dose range in children is 5-15 mg/kg per day.
Slovenian: Razpon odmerka pri otrocih je 5-15 mg/kg na dan.
English: Concomitant administration of chenodeoxycholic acid with phenobarbital increases HMG CoA reductase and thus counteracts one of the pharmacodynamics effects of chenodeoxycholic acid in CTX.
Slovenian: Sočasna uporaba henodeoksiholne kisline s fenobarbitalom povečuje HMG CoA reduktazo in s tem preprečuje enega od farmakodinamičnih učinkov henodeoksiholne kisline pri bolnikih s CTX.
English: No data are available for patients with hepatic impairment.
Slovenian: Ni podatkov za bolnike z okvaro ledvic.
English: Chenodeoxycholic acid capsules can be taken without regards to food.
Slovenian: Kapsule henodeoksiholne kisline se lahko jemljejo ne glede na hrano.
English: In CTX, a defect in the CYP27A1 gene results in a deficient mitochondrial sterol 27-hydroxylase enzyme.
Slovenian: CTX napaka v genu CYP27A1 povzroča pomanjkanje mitohondrijskega encima sterol 27hidroksilaze.
English: In the intestine Chenodeoxycholic acid and its glycine or taurine conjugate are decomposed by bacteria.
Slovenian: V črevesu se henodeoksiholna kislina in vezana glicin ali tavrin razgradita z bakterijami.
English: The primary pharmacodynamic effects of chenodeoxycholic acid are: 1.
Slovenian: Primarni farmakodinamični učinki henodeoksiholne kisline so:
English: The following medicines may affect the levels of Chenodeoxycholic acid Leadiant:
Slovenian: Naslednja zdravila lahko vplivajo na raven henodeoksiholne kisline:
English: Reduced production of cholestanol: reduces serum cholestanol (action on HMG CoA reductase and CYP7A1).
Slovenian: Manjša produkcija holestanola: zmanjša serum holestanol (učinek na HMG CoA reduktazo in CYP7A1).
English: After treatment with chenodeoxycholic acid, the endogenous synthesis of the primary bile acids, cholic acid and chenodeoxycholic acid, is inhibited.
Slovenian: Po zdravljenju z henodeoksiholno kislino se pojavi inhibicija endogenske sinteze primarnih žolčnih kislin, holne kisline in henodeoksiholne kisline.
English: Chenodeoxycholic acid is an endogenous bile acid in humans, which is tightly regulated by its secretion into bile via exporter pumps and detoxification by sulfation.
Slovenian: Henodeoksiholna kislina je endogena žolčna kislina pri ljudeh, ki se tesno regulira z izločanjem v žolč preko črpalk in razstrupljanja s sulfatiranjem.
English: In two-non interventional studies with chenodeoxycholic acid, a total of 14 paediatric patients with CTX were treated with Chenodeoxycholic acid: 1 infant (0 to < 2 years), 6 children (2 to < 12 years) and 7 adolescents (12 to < 18 years).
Slovenian: CTX zdravljenih s henodeoksiholno kislino: 1 otrok (0 do <2 leti), 6 otrok (2 do <12 let) in 7