FrancophonIA/ELRC3.0 huggingface dataset:
English: After removal, do not put the needle cap back onto the pen, as it may accidentally start the injection.
Croatian: Nakon što skinete zatvarač igle, nemojte ga vraćati na brizgalicu kako ne biste slučajno započeli injiciranje.
English: Make sure the security seals are not broken
Croatian: Uvjerite se da sigurnosne naljepnice nisu potrgane
English: Nucala may be self-administered by the patient or administered by a caregiver if their healthcare professional determines that it is appropriate, and the patient or caregiver are trained in injection techniques.
Croatian: Bolesnik može samostalno injicirati lijek Nucala ili mu ga može dati njegovatelj ako liječnik to ocijeni prikladnim i ako bolesnik ili njegovatelj prođu obuku o tehnici injiciranja.
English: Failure to follow these instructions may affect proper function of the pre-filled syringe.
Croatian: Nepridržavanje ovih uputa može utjecati na ispravno funkcioniranje napunjene brizgalice.
English: Each vial of Nucala should be used for a single patient, and any remainder of the vial should be discarded.
Croatian: Jedna bočica lijeka Nucala smije se upotrijebiti samo za jednog bolesnika, a sav preostali lijek u bočici mora se baciti.
English: These reactions generally occur within hours of administration, but in some instances have a delayed onset (i.e., typically within several days).
Croatian: Te se reakcije u načelu javljaju unutar nekoliko sati od primjene lijeka, no u nekim su slučajevima nastupile kasnije (obično nakon nekoliko dana).
English: • Keep refrigerated before use.
Croatian: • Čuvati u hladnjaku prije primjene.
English: • Remove the needle cap from the syringe by firmly pulling it straight off, extending your hand away from the needle end (as shown).
Croatian: • Skinite zatvarač igle tako da ga snažno povučete ravno sa štrcaljke pružajući ruku dalje od vrha igle (kao što je prikazano na slici).
English: Patients continued to receive their existing asthma medicine during the study with the exception of their OCS dose which was reduced every 4 weeks during the OCS reduction phase (Weeks 4-20), as long as asthma control was maintained.
Croatian: Bolesnici su tijekom ispitivanja nastavili primati svoje dotadašnje lijekove za astmu, osim što im se doza OKS-a smanjivala svaka 4 tjedna tijekom faze smanjenja primjene OKS-a (4. - 20. tjedan) sve dok je bila održana kontrola astme.
English: Nucala contains the active substance mepolizumab, a monoclonal antibody, a type of protein designed to recognise a specific target substance in the body.
Croatian: Nucala sadrži djelatnu tvar mepolizumab, monoklonsko protutijelo, što je jedna vrsta proteina oblikovana tako da prepozna specifičnu ciljnu tvar u tijelu.
English: • urinary tract infection (blood in urine, painful and frequent urination, fever, pain in lower back)
Croatian: • infekcija mokraćnih putova (krv u mokraći, bolno i često mokrenje, vrućica, bol u donjem dijelu leđa)
English: • fainting, dizziness, feeling lightheaded (due to a drop in blood pressure)
Croatian: • nesvjesticu, omaglicu, ošamućenost (zbog pada krvnog tlaka)
English: This medicine is not intended for use in children below 6 years of age.
Croatian: Ovaj lijek nije namijenjen za primjenu u djece mlađe od 6 godina.
English: The pre-filled pen or pre-filled syringe must be administered within 8 hours once the pack is opened.
Croatian: Lijek u napunjenoj brizgalici ili napunjenoj štrcaljki mora se primijeniti unutar 8 sati nakon otvaranja pakiranja.
English: Since mepolizumab is degraded by widely distributed proteolytic enzymes, not restricted to hepatic tissue, changes in hepatic function are unlikely to have any effect on the elimination of mepolizumab.
Croatian: Budući da se mepolizumab razgrađuje djelovanjem proteolitičkih enzima koji su rasprostranjeni po cijelom tijelu, a ne samo u tkivu jetre, nije vjerojatno da bi promjene u jetrenoj funkciji utjecale na eliminaciju mepolizumaba.
English: Before administration, the solution should be inspected visually.
Croatian: Prije primjene otopinu je potrebno vizualno pregledati.
English: • Once complete, release the pinched skin.
Croatian: • Nakon što dovršite injiciranje, otpustite nabor kože.
English: Mepolizumab pharmacokinetics in adolescent subjects with severe refractory eosinophilic asthma included in the phase 3 studies were consistent with adults (see section 4.2).
Croatian: Farmakokinetika mepolizumaba u adolescentnih ispitanika s teškom refraktornom eozinofilnom astmom uključenih u ispitivanja faze 3 bila je u skladu s onom u odraslih (vidjeti dio 4.2).
English: Allergic and injection site reactions
Croatian: Alergijske reakcije i reakcije na mjestu primjene injekcije
English: • Place the pen straight onto your injection site with the yellow needle guard flat against the surface of your skin, as shown.
Croatian: • Namjestite brizgalicu ravno na mjesto injiciranja tako da je žuti štitnik igle položen ravno na površinu kože, kao što je prikazano na slici.
English: Nucala is given by injection just under the skin (subcutaneous injection).
Croatian: Nucala se primjenjuje injekcijom tik pod kožu (supkutana injekcija).
English: Following subcutaneous administration to healthy subjects or patients with asthma, mepolizumab was absorbed slowly with a median time to reach maximum plasma concentration (Tmax) ranging from 4 to 8 days.
Croatian: Nakon supkutane primjene u zdravih ispitanika ili bolesnika s astmom, mepolizumab se apsorbirao sporo, a medijan vremena do postizanja maksimalne koncentracije u plazmi (Tmax) kretao se u rasponu od 4 do 8 dana.
English: • Do not use the syringe if it appears damaged.
Croatian: • Nemojte upotrijebiti štrcaljku ako izgleda oštećeno.
English: Mepolizumab is a humanised monoclonal antibody (IgG1, kappa), which targets human interleukin-5 (IL-5) with high affinity and specificity.
Croatian: Mepolizumab je humanizirano monoklonsko protutijelo (IgG1 kapa), koje s visokim afinitetom i specifičnošću ciljano djeluje na humani interleukin-5 (IL-5).
English: Following a single subcutaneous administration in the abdomen, thigh or arm of healthy subjects, mepolizumab absolute bioavailability was 64%, 71% and 75%, respectively.
Croatian: Nakon supkutane primjene jedne doze u abdomen, bedro ili nadlakticu zdravih ispitanika, apsolutna bioraspoloživost mepolizumaba iznosila je 64%, 71% odnosno 75%.
English: Oral corticosteroid reduction study MEA115575 (SIRIUS)
Croatian: Ispitivanje smanjenja primjene oralnih kortikosteroida MEA115575 (SIRIUS)
English: Nucala contains sodium
Croatian: Nucala sadrži natrij
English: The possible side effects of Nucala are unlikely to affect your ability to drive or use machines.
Croatian: Nije vjerojatno da bi moguće nuspojave lijeka Nucala mogle utjecati na Vašu sposobnost upravljanja vozilima ili rada sa strojevima.
English: Table 1: Frequency of clinically significant exacerbations at week 52 in the intent to treat population
Croatian: Tablica 1: Učestalost klinički značajnih egzacerbacija u 52. tjednu u populaciji koju se namjeravalo liječiti
English: Mepolizumab, the active substance in Nucala, blocks a protein called interleukin-5.
Croatian: Mepolizumab, djelatna tvar u lijeku Nucala, blokira protein pod nazivom interleukin-5.
English: Automatic needle guard
Croatian: Automatski štitnik igle
English: Mepolizumab 100 mg (subcutaneous) N= 194
Croatian: Mepolizumab 100 mg (supkutano) N= 194
English: ≥500 cells/µL
Croatian: ≥500 stanica/µl n
English: MEA115575 evaluated the effect of mepolizumab 100 mg administered subcutaneously on reducing the requirement for maintenance oral corticosteroids (OCS) while maintaining asthma control in subjects with severe refractory eosinophilic asthma.
Croatian: U ispitivanju MEA115575 ocjenjivao se učinak mepolizumaba u dozi od 100 mg primijenjenoj supkutano na smanjenje potrebe za oralnim kortikosteroidima (OKS) u terapiji održavanja uz istodobno održanu kontrolu astme u ispitanika s teškom refraktornom eozinofilnom astmom.
English: Do not use the syringe if the security seal on the carton is broken.
Croatian: Nemojte upotrijebiti štrcaljku ako je sigurnosna naljepnica na kutiji potrgana.
English: For instructions on the reconstitution of the medicinal product before administration, see section 6.6.
Croatian: Za uputu o rekonstituciji lijeka prije primjene vidjeti dio 6.6.
English: A total of 896 adults and 19 adolescent subjects with severe refractory eosinophilic asthma received either a subcutaneous or an intravenous dose of mepolizumab during three placebo-controlled clinical studies of 24 to 52 weeks duration.
Croatian: Ukupno je 896 odraslih ispitanika i 19 adolescenata s teškom refraktornom eozinofilnom astmom primilo supkutanu ili intravensku dozu mepolizumaba tijekom tri placebom kontrolirana klinička ispitivanja u trajanju od 24 do 52 tjedna.
English: Check the security seals are not broken.
Croatian: Uvjerite se da sigurnosne naljepnice nisu potrgane.
English: Mepolizumab is a humanised monoclonal antibody produced in Chinese hamster ovary cells by recombinant DNA technology.
Croatian: Mepolizumab je humanizirano monoklonsko protutijelo, proizvedeno na stanicama jajnika kineskog hrčka tehnologijom rekombinantne DNK.
English: Secondary endpoints Frequency of exacerbations requiring hospitalisations/emergency room visits
Croatian: Učestalost egzacerbacija koje su zahtijevale hospitalizaciju/posjete hitnoj službi
English: The trade name (Nucala) and batch number of the administered product should be clearly recorded in the patient file.
Croatian: Naziv (Nucala) i broj serije primijenjenog lijeka potrebno je jasno evidentirati u zdravstvenom kartonu bolesnika.
English: Nucala is for subcutaneous injection only and should be administered by a healthcare professional.
Croatian: Nucala se primjenjuje isključivo supkutanom injekcijom i mora je primijeniti zdravstveni radnik.
English: Do not warm the syringe in a microwave, hot water, or direct sunlight.
Croatian: Nemojte zagrijavati brizgalicu u mikrovalnoj pećnici, vrućoj vodi ili na izravnoj sunčevoj svjetlosti.
English: ITT Population Mepolizumab 100 mg (subcutaneous) N= 69
Croatian: ITT populacija Mepolizumab 100 mg (supkutano) N= 69
English: Nucala is given to you by a doctor, nurse or healthcare professional, as an injection just under the skin (subcutaneously).
Croatian: Lijek Nucala dat će Vam liječnik, medicinska sestra ili zdravstveni radnik u obliku injekcije tik pod kožu (supkutano).
English: Do not lift the pen from your skin at this stage, as that may mean you don't get your full dose of medicine.
Croatian: Nemojte još podizati brizgalicu s kože jer inače možda nećete primiti cijelu dozu lijeka.
English: If a dose of Nucala is missed
Croatian: Ako propustite dozu lijeka Nucala
English: Intravenous and subcutaneous administration to monkeys was associated with reductions in peripheral and lung eosinophil counts, with no toxicological findings.
Croatian: Intravenska i supkutana primjena u majmuna bila je povezana sa smanjenjem broja eozinofila u perifernoj krvi i plućima, bez toksikoloških nalaza.
English: Exacerbation rate/year Percent reduction
Croatian: Stopa egzacerbacija/godina Postotak smanjenja
English: MEA115588 was a randomised, double-blind, placebo-controlled, parallel-group, multi-centre study which evaluated the efficacy and safety of mepolizumab as add-on therapy in 576 patients with severe refractory eosinophilic asthma defined as peripheral blood eosinophils greater than or equal to 150 cells/μL at initiation of treatment or greater than or equal to 300 cells/μL within the past 12 months.
Croatian: MEA115588 je bilo randomizirano, dvostruko slijepo, placebom kontrolirano, multicentrično ispitivanje s paralelnim skupinama, u kojem su se ispitivale djelotvornost i sigurnost mepolizumaba kao dodatne terapije u 576 bolesnika s teškom refraktornom eozinofilnom astmom, definiranom kao vrijednost eozinofila u perifernoj krvi od 150 stanica/μl ili više na početku liječenja ili 300 stanica/μl ili više unutar posljednjih 12 mjeseci.
English: • Look in the inspection window to check that the liquid is clear (free from cloudiness or particles)
Croatian: • Pogledajte kroz prozorčić za provjeru kako biste se uvjerili da je otopina bistra (nije zamućena i ne sadrži čestice) i bezbojna do blijedožuta ili blijedosmeđa.
English: Do not touch the plunger at this stage, as you can accidentally push liquid out and will not receive your full dose.
Croatian: Nemojte još dodirivati klip kako ne biste slučajno istisnuli tekućinu, jer u tom slučaju nećete primiti cijelu dozu.
English: Each vial contains 100 mg mepolizumab (100 mg/ml after reconstitution)
Croatian: Jedna bočica sadrži 100 mg mepolizumaba (100 mg/ml nakon rekonstitucije)
English: Following reconstitution, Nucala should be visually inspected for particulate matter and clarity prior to use.
Croatian: Nakon rekonstitucije, lijek Nucala treba prije primjene vizualno pregledati kako bi se utvrdilo sadrži li čestice i je li bistar.
English: • Place the syringe on a clean, flat surface, at room temperature, away from direct sunlight and out of the reach of children.
Croatian: • Stavite brizgalicu na čistu, ravnu površinu, na sobnu temperaturu, podalje od izravne sunčeve svjetlosti i izvan dohvata djece.
English: Investigation of a 40 mg subcutaneous dosing regimen administered every 4 weeks in children 6 to 11 years old over a 15-70 kg broad weight range by PK modelling and simulation predicts that the exposure of this dosing regimen would remain on average within 38% of adults at 100 mg.
Croatian: Ispitivanje režima liječenja supkutanom dozom od 40 mg primijenjenom svaka 4 tjedna u djece u dobi od 6 do 11 godina i tjelesne težine u širokom rasponu od 15 do 70 kg, provedeno farmakokinetičkim modeliranjem i simulacijom, predviđa da bi se izloženost lijeku kod tog režima doziranja u prosjeku zadržala unutar 38% izloženosti zabilježene u odraslih kod primjene doze od 100 mg.
English: • injection-site reaction (pain, redness, swelling, itching, and burning sensation of the skin near where the injection was given)
Croatian: • reakcije na mjestu injiciranja (bol, crvenilo, oticanje, svrbež i osjećaj žarenja kože u blizini mjesta primjene injekcije)
English: St. George's Respiratory Questionnaire (SGRQ) at week 32
Croatian: George's' (SGRQ) u 32. tjednu
English: The efficacy of mepolizumab in the treatment of a targeted group of patients with severe refractory eosinophilic asthma was evaluated in 3 randomised, double-blind, parallel-group clinical studies of between 24-52 weeks duration, in patients aged 12 years and older.
Croatian: Djelotvornost mepolizumaba u liječenju ciljne skupine bolesnika s teškom refraktornom eozinofilnom astmom ocijenjena je u 3 randomizirana, dvostruko slijepa klinička ispitivanja s paralelnim skupinama, u trajanju od 24 do 52 tjedna, s bolesnicima u dobi od 12 i više godina.
English: Do not remove the needle cap during this step.
Croatian: Nemojte skidati zatvarač igle u ovom koraku.
English: There is no specific treatment for an overdose with mepolizumab.
Croatian: Nema posebne terapije za predoziranje mepolizumabom.
English: The posology of Nucala in children and adolescents aged between 6 to 17 years old with severe refractory eosinophilic asthma has been determined by limited efficacy, pharmacokinetic and pharmacodynamic studies and supported by modelling and simulation data (see sections 5.1 and 5.2).
Croatian: Doziranje lijeka Nucala u djece i adolescenata s teškom refraktornom eozinofilnom astmom u dobi od 6 do 17 godina utvrđeno je na temelju ograničenih ispitivanja djelotvornosti, farmakokinetike i farmakodinamike, a podupiru ga podaci dobiveni modeliranjem i simuliranjem (vidjeti dijelove 5.1 i
English: Do not use the syringe if left out of the carton for more than 8 hours.
Croatian: Nemojte upotrijebiti brizgalicu ako je bila izvan kutije dulje od 8 sati.
English: Don't suddenly stop taking your preventer medicines for your asthma once you have started Nucala.
Croatian: Ne smijete naglo prestati uzimati lijekove koje koristite za sprječavanje napadaja astme nakon što započnete liječenje lijekom Nucala.
English: The pre-filled syringe should be used only once and then discarded.
Croatian: Napunjena štrcaljka smije se upotrijebiti samo jednom i zatim je treba baciti.
English: Just prior to administration, remove 1 mL of reconstituted Nucala.
Croatian: Neposredno prije primjene izvucite 1 ml rekonstituiranog lijeka Nucala.
English: What Nucala looks like and contents of the pack
Croatian: Kako Nucala izgleda i sadržaj pakiranja
English: In patients with asthma the absolute bioavailability of mepolizumab administered subcutaneously in the arm ranged from 74-80%.
Croatian: U bolesnika s astmom, apsolutna bioraspoloživost mepolizumaba primijenjenog supkutano u nadlakticu kretala se između 74% i 80%.
English: Table 3: Combined analysis of the rate of clinically significant exacerbations by baseline blood eosinophil count in patients with severe refractory eosinophilic asthma
Croatian: Tablica 3: Kombinirana analiza stope klinički značajnih egzacerbacija prema početnoj vrijednosti eozinofila u krvi bolesnika s teškom refraktornom eozinofilnom astmom
English: Exacerbation reduction MEA115588 (MENSA) study
Croatian: Ispitivanje smanjenja egzacerbacija MEA115588 (MENSA)
English: Stopping treatment with Nucala
Croatian: Prestanak liječenja lijekom Nucala
English: In a combined analysis of these studies, a 40% reduction in clinically significant exacerbations was observed in adolescents following mepolizumab treatment compared to placebo (rate ratio 0.60; 95% CI: 0.17, 2.10).
Croatian: U analizi objedinjenih podataka iz tih ispitivanja opaženo je smanjenje stope klinički značajnih egzacerbacija za 40% u adolescenata koji su primali mepolizumab u odnosu na one koji su primali placebo (omjer stopa: 0,60; 95% CI: 0,17; 2,10).
English: Alternatively, swirling at 1000 rpm for no longer than 5 minutes is acceptable.
Croatian: Druga prihvatljiva mogućnost je vrtnja pri brzini od 1000 rpm tijekom najviše 5 minuta.
English: Complete your injection
Croatian: Dovršite injiciranje
English: After use, the automatic needle guard is activated and pulls up (retracts) the needle.
Croatian: Nakon uporabe aktivira se automatski štitnik igle koji uvlači iglu u štrcaljku.
English: Just prior to administration, remove 0.4mL of reconstituted Nucala.
Croatian: Neposredno prije primjene izvucite 0,4 ml rekonstituiranog lijeka Nucala.
English: There are no data regarding the excretion of mepolizumab in human milk.
Croatian: Nema podataka o izlučivanju mepolizumaba u majčino mlijeko u ljudi.
English: Acute and delayed systemic reactions, including hypersensitivity reactions (e.g. anaphylaxis, urticaria, angioedema, rash, bronchospasm, hypotension), have occurred following administration of Nucala.
Croatian: Nakon primjene lijeka Nucala nastupile su akutne i odgođene sistemske reakcije, uključujući reakcije preosjetljivosti (npr. anafilaksija, urtikarija, angioedem, osip, bronhospazam, hipotenzija).
English: As mepolizumab is a monoclonal antibody, no genotoxicity or carcinogenicity studies have been conducted.
Croatian: Budući da je mepolizumab monoklonsko protutijelo, nisu provedena ispitivanja genotoksičnosti ni kancerogenog potencijala.
English: Table 3 shows the results of a combined analysis of the two exacerbation studies (MEA112997 and MEA115588) by baseline blood eosinophil count.
Croatian: U Tablici 3 prikazani su rezultati kombinirane analize dvaju ispitivanja egzacerbacija (MEA112997 i MEA115588) prema početnoj vrijednosti eozinofila u krvi.
English: Hypersensitivity and administration-related reactions
Croatian: Reakcije preosjetljivosti i reakcije na primjenu lijeka
English: 300 to <500 cells/µL
Croatian: 300 do <500 stanica/µl n
English: Clear, colourless 10 mL type I glass vial, with bromobutyl rubber stopper and a grey aluminium overseal with a plastic flip-cap containing 100 mg powder for solution for injection.
Croatian: Prozirna, bezbojna, staklena bočica (staklo tipa I), volumena 10 ml, s brombutilnim gumenim čepom i sivim aluminijskim zaštitnim zatvaračem s plastičnom kapicom, koja sadrži 100 mg praška za otopinu za injekciju.
English: Mepolizumab is a humanized IgG1 monoclonal antibody degraded by proteolytic enzymes which are widely distributed in the body and not restricted to hepatic tissue.
Croatian: Mepolizumab je humanizirano IgG1 monoklonsko protutijelo koje se razgrađuje djelovanjem proteolitičkih enzima koji su rasprostranjeni po cijelom tijelu, a ne samo u tkivu jetre.
English: If your asthma symptoms get worse while receiving injections of Nucala:
Croatian: Ako Vam se simptomi astme pogoršaju dok primate injekcije lijeka Nucala:
English: Do not shake the reconstituted solution during the procedure as this could lead to product foaming or precipitation.
Croatian: Pritom nemojte tresti rekonstituiranu otopinu jer to može uzrokovati pjenjenje ili precipitaciju.
English: Security seals
Croatian: Sigurnosne naljepnice
English: In 2 placebo-controlled studies the incidence of local injection site reactions with mepolizumab 100 mg subcutaneous and placebo was 8% and 3%, respectively.
Croatian: U 2 placebom kontrolirana ispitivanja, incidencija lokalnih reakcija na mjestu injiciranja iznosila je 8% uz mepolizumab u supkutanoj dozi od 100 mg i 3% uz placebo.
English: • pharyngitis (sore throat)
Croatian: • faringitis (upala grla)
English: GlaxoSmithKline Manufacturing S.P.A. Strada Provinciale Asolana No. 90, Torrile, 43056, Parma, Italy
Croatian: GlaxoSmithKline Manufacturing S.P.A., Strada Provinciale Asolana No. 90, Torrile, 43056, Parma Italija ili
English: Slowly push down
Croatian: Polagano potiskujte
English: Keep the skin pinched throughout your injection.
Croatian: Držite nabor kože sve do završetka injekcije.
English: Start your injection
Croatian: Započnite injiciranje
English: • Check the expiry date on the label of the syringe.
Croatian: • Provjerite rok valjanosti na naljepnici brizgalice.
English: The pack should be discarded if not administered within 8 hours.
Croatian: Lijek treba baciti ako se ne primijeni unutar 8 sati.
English: Clean your injection site
Croatian: Očistite mjesto za injiciranje
English: Do not inject if the solution looks cloudy or discoloured, or has particles.
Croatian: Nemojte injicirati lijek ako otopina izgleda mutno, ako je promijenila boju ili ako sadrži čestice.
English: EU/1/15/1043/003 1 pre-filled pen EU/1/15/1043/004 3 (3 x 1) pre-filled pens (multipack)
Croatian: EU/1/15/1043/003 1 napunjena brizgalica EU/1/15/1043/004 3 (3 x 1) napunjene brizgalice (višestruko pakiranje) EU/1/15/1043/005 1 napunjena štrcaljka EU/1/15/1043/006 3 (3 x 1) napunjene štrcaljke (višestruko pakiranje)
English: Paediatric pharmacokinetics were broadly consistent with adults and adolescents after accounting for bodyweight and bioavailability.
Croatian: Farmakokinetika u pedijatrijskih bolesnika uvelike je odgovarala onoj u odraslih i adolescenata kada su se u obzir uzele tjelesna težina i bioraspoloživost.
English: The reduction rate with mepolizumab was greater in patients with higher blood eosinophil counts.
Croatian: Stopa smanjenja uz mepolizumab bila je veća u bolesnika s većim početnim brojem eozinofila u krvi.
English: 150 to <300 cells/µL
Croatian: 150 do <300 stanica/µl n
English: Children
Croatian: DJECE
English: If you are not sure what to do, ask your doctor, pharmacist or nurse.
Croatian: Ako niste sigurni što učiniti, obratite se svom liječniku, ljekarniku ili medicinskoj sestri.
English: Following a single intravenous administration to patients with asthma, the mean systemic clearance (CL) ranged from 1.9 to 3.3 mL/day/kg, with a mean terminal half-life of approximately 20 days.
Croatian: Nakon intravenske primjene jedne doze u bolesnika s astmom, srednja vrijednost sistemskog klirensa (CL) kretala se u rasponu od 1,9 do 3,3 ml/kg na dan, a srednja vrijednost terminalnog poluvijeka iznosila je približno 20 dana.
English: Following a single intravenous administration to patients with asthma, mepolizumab distributes into a mean volume of distribution of 55 to 85 mL/kg.
Croatian: Nakon intravenske primjene jedne doze u bolesnika s astmom, mepolizumab se raspodjeljuje uz srednju vrijednost volumena distribucije od 55 do 85 ml/kg.