FrancophonIA/ELRC3.0 huggingface dataset:
English: ) row of the blister can be disregarded.
Slovenian: vrste pretisnega omota se lahko izpusti.
English: • if you need an operation or if you are off your feet for a long time (see in section 2 ‘Blood clots).
Slovenian: • če potrebujete kirurški poseg ali če dolgo časa niste na nogah (glejte v poglavju 2 "Krvni strdki");
English: 4.1 Therapeutic indications
Slovenian: 4.1 Terapevtske indikacije peroralna kontracepcija
English: Follow the direction of the arrows on the blister, so use the white active tablets first and then the yellow placebo tablets.
Slovenian: Upoštevajte smer, ki jo kažejo puščice na pretisnem omotu, kar pomeni, da boste najprej jemali bele aktivne tablete in potem še rumene placebo tablete.
English: Symptoms of pulmonary embolism (PE) can include: - sudden onset of unexplained shortness of breath or rapid breathing; - sudden coughing which may be associated with haemoptysis; - sharp chest pain; - severe light headedness or dizziness; - rapid or irregular heartbeat.
Slovenian: Med simptomi pljučne embolije (PE) so lahko: - nenaden pojav nepojasnjene kratke sape ali hitrega dihanja, - nenaden kašelj, ki je lahko povezan s hemoptizo, - ostra bolečina v prsih, - huda vrtoglavica ali omotica, - hitro ali neredno bitje srca.
English: Oral exogenous estradiol is extensively metabolized.
Slovenian: Peroralno uporabljen eksogeni estradiol se obsežno presnovi.
English: The excess risk gradually disappears during the course of the 10 years after cessation of COC use.
Slovenian: V času 10 let po prenehanju uporabe COC to dodatno tveganje postopoma izginja.
English: • increased appetite; fluid retention (oedema)
Slovenian: • povečan tek, zadrževanje tekočine v telesu (edem)
English: Provided that the woman has taken her tablets correctly in the 7 days preceding the first missed tablet, there is no need to use extra contraceptive precautions.
Slovenian: Če je ženska pravilno jemala tablete 7 dni preden je izpustila prvo tableto, dodatni kontracepcijski ukrepi niso potrebni.
English: Each white active film-coated tablet contains 57.71 mg of lactose monohydrate.
Slovenian: Ena bela filmsko obložena tableta z zdravilno učinkovino vsebuje 57,71 mg laktoze monohidrata.
English: Other medical conditions associated with VTE Cancer, systemic lupus erythematosus, haemolytic uraemic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) and sickle cell disease
Slovenian: Rak, sistemski eritematozni lupus, hemolitičnouremični sindrom, kronična vnetna bolezen črevesja (Crohnova bolezen ali ulcerozni kolitis) in bolezen srpastih celic
English: Zoely 2.5 mg/1.5 mg film-coated tablets
Slovenian: Zoely 2,5 mg/1,5 mg filmsko obložene tablete
English: In rare cases, benign (noncancerous) liver tumours, and in even fewer cases malignant (cancerous) liver tumours have been reported in pill users.
Slovenian: V redkih primerih so pri uporabnicah kontracepcijskih tablet poročali o benignih (nerakavih) jetrnih tumorjih, v še redkejših primerih pa o malignih (rakavih) jetrnih tumorjih.
English: Seek urgent medical attention if you notice any of the following signs or symptoms.
Slovenian: Če opazite katerega koli od naslednjih znakov ali simptomov, poiščite nujno medicinsko pomoč.
English: Zoely comes in blisters of 28 film-coated tablets (24 white active film-coated tablets and 4 yellow placebo film-coated tablets) packed in a ply carton.
Slovenian: Zdravilo Zoely je na voljo v pretisnih omotih po 28 filmsko obloženih tablet (24 belih aktivnih filmsko obloženih tablet in 4 rumene placebo filmsko obložene tablete), pakiranih v kartonske škatle.
English: Usually it will start 2-3 days after the last white active tablet and may not have finished before the next blister is started.
Slovenian: Običajno se menstruacija začne 2 do 3 dni po zaužitju zadnje bele aktivne tablete in bo lahko še trajala, ko boste začeli jemati tablete iz naslednjega pretisnega omota.
English: Cervical cancer is caused by an infection with the human papilloma virus (HPV).
Slovenian: Okužba s humanim papiloma virusom (HPV) povzroča raka materničnega vratu.
English: • increased sweating; hair loss; itching; dry skin; oily skin
Slovenian: • povečano potenje, izpadanje las, srbenje, suha koža, mastna koža
English: • if you have sickle cell anaemia (an inherited disease of the red blood cells);
Slovenian: • če imate anemijo srpastih celic (dedno bolezen rdečih krvničk);
English: The following advice only refers to missed white active tablets:
Slovenian: Spodnji nasveti se nanašajo le na pozabljene bele tablete z zdravilno učinkovino:
English: The metabolism of exogenous and endogenous estradiol is similar.
Slovenian: Presnova eksogenega in endogenega estradiola je podobna.
English: If you had sexual intercourse in the week before missing the tablets, there is a possibility of becoming or being pregnant.
Slovenian: Če ste imeli spolni odnos v tednu, preden ste pozabili vzeti tablete, obstaja možnost, da boste zanosili ali da ste noseči, zato se morate nemudoma posvetovati z zdravnikom.
English: 4.6 % of the women did not have a withdrawal bleeding in the first three cycles of use and the occurrences of absence of withdrawal bleeding in the later cycles of use were high in this subgroup, ranging from 76 % to 87 % of women.
Slovenian: Pojavnost odsotnosti odtegnitvene krvavitve v poznejših ciklusih uporabe je bila v tej podskupini velika in je znašala od 76 % do 87 % žensk.
English: The next tablet should then be taken at the usual time.
Slovenian: Naslednjo tableto mora nato vzeti ob običajnem času.
English: Skin and subcutaneous tissue disorders acne hyperhydrosis, alopecia, pruritus, dry skin, seborrhea chloasma, hypertrichosis
Slovenian: Bolezni kože in podkožja akne hiperhidroza, alopecija, pruritus, suha koža, seboreja kloazma, hipertrihoza
English: Option 1)
Slovenian: 1. možnost:
English: Due to metabolism and enterohepatic circulation, a large circulating pool of oestrogen sulfates and glucuronides is present.
Slovenian: Zaradi presnove in enterohepatičnega obtoka kroži po telesu velika količina estrogen sulfatov in glukuronidov.
English: Take the last missed white active tablet as soon as you remember (even if this means taking two tablets at the same time) and take the next tablets at the usual time.
Slovenian: Vzemite zadnjo pozabljeno belo aktivno tableto, kakor hitro se spomnite (tudi če to pomeni, da boste vzeli dve tableti ob istem času), naslednje tablete pa jemljite ob običajnem času.
English: • if you are 24 or more hours late in taking any tablet, the reliability of the pill may be reduced.
Slovenian: • Če z jemanjem katere koli tablete zamujate 24 ur ali več, je zanesljivost kontracepcijskih tablet lahko zmanjšana.
English: • Presence or risk of venous thromboembolism (VTE) o Venous thromboembolism - current VTE (on anticoagulants) or history of (e.g. deep venous thrombosis [DVT] or pulmonary embolism [PE]).
Slovenian: • Prisotna venska trombembolija (VTE) ali tveganje zanjo o Venska trombembolija - obstoječa VTE (zdravljena z antikoagulanti) ali VTE v anamnezi (npr. globoka venska tromboza [DVT - deep venous thrombosis] ali pljučna embolija [PE - pulmonary embolism]).
English: • if you have unusual, heavy vaginal bleeding;
Slovenian: • če imate nenavadne, močne krvavitve iz nožnice;
English: • Presence or history of liver tumours (benign or malignant).
Slovenian: • Jetrni tumorji ali jetrni tumorji v anamnezi (benigni ali maligni).
English: When changing from an injectable, Zoely should be started on the day when the next injection would have been due.
Slovenian: Pri prehodu z injekcij naj začne ženska jemati zdravilo Zoely na dan, ko bi bila na vrsti naslednja injekcija.
English: With all combined pills, for the first few months, you can have some irregular vaginal bleeding (spotting or breakthrough bleeding) between your periods.
Slovenian: Pri vseh kombiniranih kontracepcijskih tabletah imate lahko v prvih nekaj mesecih neredne krvavitve iz nožnice (krvave madeže ali vmesne krvavitve) med posameznimi menstruacijami.
English: Nomegestrol acetate has a strong affinity for the human progesterone receptor and has an anti-gonadotropic activity, a progesterone receptor-mediated anti-oestrogenic activity, a moderate anti-androgenic activity, and is devoid of any oestrogenic, androgenic, glucocorticoid or mineralocorticoid activity.
Slovenian: Kaže proti-gonadotropno delovanje, s progesteronskim receptorjem posredovano proti-estrogeno delovanje, zmerno protiandrogeno delovanje, nima pa nikakršnega estrogenskega, androgenega, glukokortikoidnega ali mineralokortikoidnega delovanja.
English: • if you have haemolytic uraemic syndrome (HUS - a disorder of blood clotting causing failure of the kidneys);
Slovenian: • če imate hemolitično uremični sindrom (motnjo strjevanja krvi, ki povzroča ledvično odpoved);
English: By adjusting your intake schedule this higher risk can be prevented.
Slovenian: To povečano tveganje lahko preprečite s prilagoditvijo sheme jemanja zdravila.
English: Option 2)
Slovenian: 2. možnost:
English: Blood clots blocking other blood vessels
Slovenian: Krvni strdki, ki zamašijo druge žile
English: Take the tablet as soon as you remember and take the next tablets at the usual time.
Slovenian: Vzemite tableto, kakor hitro se spomnite, naslednje tablete pa jemljite ob običajnem času.
English: You can start Zoely between 21 and 28 days after having a baby.
Slovenian: Z jemanjem zdravila Zoely lahko začnete med 21. in 28. dnem po porodu.
English: Day 18-24 of white active tablet intake (see picture and schedule) There is a particularly high risk of becoming pregnant if you miss white active tablets close to the yellow placebo tablet interval.
Slovenian: 18. do 24. dan jemanja belih aktivnih tablet (glejte sliko in shemo) Če pozabite vzeti bele aktivne tablete blizu časa jemanja rumenih placebo tablet, je možnost zanositve še posebej velika.
English: Non-interventional post-authorisation safety study (PASS): A prospective observational study to assess in particular the risk of Venous thromboembolic events (VTE) and ATE in nomegestrol/estradiol users compared with the VTE risk in users of combined oral contraceptives containing levonorgestrel.
Slovenian: Prospektivna opazovalna študija za oceno tveganja za nastanek venskih tromboemboličnih dogodkov (VTE) in ATE pri uporabnicah nomegestrola/estradiola v primerjavi s tveganjem za nastanek VTE pri uporabnicah peroralnih kontraceptivov, ki vsebujejo levonorgestrel.
English: If you have taken several tablets at a time, you may have nausea, vomiting or vaginal bleeding.
Slovenian: Če vzamete več tablet naenkrat, lahko občutite slabost (navzeo), bruhate ali imate nožnično krvavitev.
English: If you have severe diarrhoea, please tell your doctor.
Slovenian: Če imate hudo drisko, se, prosimo, posvetujte z zdravnikom.
English: While using the next blister you may have some spotting (drops or flecks of blood) or breakthrough bleeding on white active tablet-taking days.
Slovenian: Med jemanjem naslednjega pretisnega omota boste lahko imeli nekaj krvavih madežev (kapljic ali lis krvi) oziroma boste imeli vmesne krvavitve med jemanjem belih aktivnih tablet.
English: o Cerebrovascular disease - current stroke, history of stroke or prodromal condition (e.g. transient ischaemic attack, TIA).
Slovenian: o Cerebrovaskularna bolezen - obstoječa možganska kap, možganska kap v anamnezi ali prodromalna stanja (npr. tranzitorna ishemična ataka, TIA).
English: 1 will develop a VTE in one year.
Slovenian: • Ocenjujejo, da se VTE v enem letu pojavi pri približno 6
English: • Presence or risk of arterial thromboembolism (ATE) o Arterial thromboembolism - current arterial thromboembolism, history of arterial thromboembolism (e.g. myocardial infarction) or prodromal condition (e.g. angina pectoris).
Slovenian: • Prisotna arterijska trombembolija (ATE) ali tveganje zanjo o Arterijska trombembolija - obstoječa arterijska trombembolija, arterijska trombembolija v anamnezi (npr. miokardni infarkt) ali prodromalna stanja (npr. angina pektoris).
English: Maximum plasma concentrations of nomegestrol acetate of about 12 ng/mL are reached 1.5 h after dosing.
Slovenian: Največja plazemska koncentracija nomegestrolacetata približno 12 ng/ml je dosežena 1,5 h po njegovem zaužitju.
English: In addition, a barrier method such as a condom should be used until she has completed 7 days of uninterrupted white tablettaking.
Slovenian: Poleg tega naj uporablja tudi pregradno metodo kontracepcije, na primer kondom, dokler ne zaključi 7-dnevnega obdobja neprekinjenega jemanja belih tablet.
English: Effect of hepatic impairment
Slovenian: Vpliv jetrne okvare
English: The overall risk of a blood clot in the leg or lung (DVT or PE) with Zoely is small.
Slovenian: Na splošno je tveganje za nastanek krvnega strdka v nogi ali pljučih (globoka venska tromboza ali pljučna embolija) pri zdravilu Zoely majhno.
English: When you wish your period to begin during the second blister, stop taking the white active tablets and start taking the yellow placebo tablets.
Slovenian: Ko želite dobiti menstruacijo med jemanjem drugega pretisnega omota, prenehajte z jemanjem belih aktivnih tablet in začnite jemati rumene placebo tablete.
English: Warnings
Slovenian: Opomba
English: • if a close relative has or has ever had breast cancer;
Slovenian: • če ima vaša bližnja sorodnica (oziroma je imela kdaj v preteklosti) raka dojk;
English: Zoely is contraindicated if a woman has multiple risk factors that put her at high risk of venous thrombosis (see section 4.3).
Slovenian: Zdravilo Zoely je kontraindicirano, če ima ženska več dejavnikov tveganja, zaradi katerih je njeno tveganje za vensko trombozo veliko (glejte poglavje 4.3).
English: Symptoms of a myocardial infarction (MI) can include: - pain, discomfort, pressure, heaviness, sensation of squeezing or fullness in the chest, arm, or below the breastbone; - discomfort radiating to the back, jaw, throat, arm, stomach; - feeling of being full, having indigestion or choking; - sweating, nausea, vomiting or dizziness; - extreme weakness, anxiety, or shortness of breath; - rapid or irregular heartbeats.
Slovenian: Med simptomi miokardnega infarkta (MI) so lahko: - bolečina, nelagodje, tiščanje, teža, občutek stiskanja ali polnosti v prsih, roki ali za prsnico, - nelagodje, ki se širi v hrbet, čeljust, žrelo, roko ali proti želodcu, - občutek polnosti, prebavne motnje ali dušenje, - znojenje, navzea, bruhanje ali omotica, - skrajna šibkost, tesnoba ali kratka sapa, - hitro ali neredno bitje srca.
English: When changing from another combined hormonal contraceptive (combined pill, vaginal ring, or transdermal patch)
Slovenian: Prehod z drugega kombiniranega hormonskega kontraceptiva (kombiniranih kontracepcijskih tabletk, vaginalnega obročka ali transdermalnega obliža)
English: The risk of developing a blood clot increases the more conditions you have.
Slovenian: Tveganje za nastanek krvnega strdka je toliko večje, kolikor več takih stanj imate.
English: If possible take it within 24 hours of when you normally take your pill.
Slovenian: Če je le mogoče, jo vzemite v 24 urah po tem, kot je običajno.
English: To delay a period the woman should continue with another blister pack of Zoely without taking the yellow placebo tablets from her current pack.
Slovenian: Če želi ženska odložiti menstruacijo, naj nadaljuje z jemanjem tablet iz drugega pretisnega omota zdravila Zoely ne da bi jemala rumene placebo tablete iz trenutnega pretisnega omota.
English: • All 24 white film-coated tablets are active tablets that contain a small amount of two different female hormones.
Slovenian: • Vseh 24 belih filmsko obloženih tablet predstavlja aktivne tablete, ki vsebujejo majhno količino dveh različnih ženskih hormonov, to je nomegestrolacetata (progestogena) in estradiola (estrogena).
English: If this is not the case, you should follow the first of these two options and use a barrier method such as a condom as an extra precaution until you have taken your tablets correctly for 7 days in a row.
Slovenian: Če tega niste storili, sledite prvi izmed dveh možnosti in uporabljajte pregradno metodo, na primer kondom, za dodatno zaščito, dokler ne boste tablet jemali pravilno 7 dni zaporedoma.
English: No clinically relevant effect of food was observed on the bioavailability of nomegestrol acetate.
Slovenian: Opazili niso nobenega klinično pomembnega vpliva hrane na biološko uporabnost nomegestrolacetata.
English: The yellow tablets are placebo tablets which do not contain active substances.
Slovenian: Rumene tablete so placebo tablete, ki ne vsebujejo zdravilnih učinkovin.
English: • Presence or history of severe hepatic disease as long as liver function values have not returned to normal.
Slovenian: • Obstoječa huda bolezen jeter ali huda bolezen jeter v anamnezi, pri kateri se izvidi delovanja jeter niso povrnili na normalne vrednosti.
English: Musculoskeletal and connective tissue disorders sensation of heaviness
Slovenian: Bolezni mišičnoskeletnega sistema in vezivnega tkiva občutek teže
English: o heart attack o stroke o mini-stroke or temporary stroke-like symptoms known as a transient ischaemic attack
Slovenian: o srčni infarkt o možganska kap o "mala možganska kap" ali prehodni, možganski kapi podobni simptomi, znani kot prehodni ishemični napad (TIA - tranzitorna ishemična ataka).
English: • if you have diabetes;
Slovenian: • če imate sladkorno bolezen;
English: If you start later than day 28, you should also use a barrier method of contraception during the first 7 days of Zoely use.
Slovenian: Če začnete z jemanjem po 28. dnevu, morate prvih 7 dni jemanja zdravila Zoely uporabljati še pregradno metodo kontracepcije.
English: The user should take the last missed white tablet as soon as she remembers, even if this means taking two tablets at the same time.
Slovenian: Zadnjo pozabljeno belo tableto naj ženska vzame takoj, ko se spomni, tudi če to pomeni, da bo vzela dve tableti hkrati.
English: Zoely contains lactose
Slovenian: Zdravilo Zoely vsebuje laktozo
English: Table: Risk factors for VTE Risk factor
Slovenian: Preglednica: Dejavniki tveganja za VTE Dejavnik tveganja
English: Vascular disorders hot flush venous thromboembolism
Slovenian: Žilne bolezni navali vročine venska trombembolija
English: These substances are represented mostly with anticonvulsants (e.g. carbamazepine, topiramate, phenytoin, phenobarbital, primidone, oxcarbazepine, felbamate); anti-infective drugs (e.g. rifampicin, rifabutin, griseofulvin); St. John's wort; bosentan and HIV or Hepatitis C virus (HCV) protease inhibitors (e.g. ritonavir, boceprevir, telaprevir) and non-nucleoside reverse transcriptase inhibitors (e.g. efavirenz).
Slovenian: Med te učinkovine sodijo predvsem antikonvulzivi (npr. karbamazepin, topiramat, fenitoin, fenobarbital, primidon, okskarbazepin, felbamat), antiinfektivi (npr. rifampicin, rifabutin, griseofulvin), šentjanževka, bosentan in zaviralci proteaz HIV ali virusa hepatitisa C (HCV) (npr. ritonavir, boceprevir, telaprevir) ter nenukleozidni zaviralci reverzne transkriptaze (npr. efavirenz).
English: • If a blood clot forms in a vein in the leg or foot it can cause a deep vein thrombosis (DVT).
Slovenian: • Če krvni strdek nastane v veni noge ali stopala, lahko povzroči globoko vensko trombozo.
English: • diabetes mellitus with vascular symptoms
Slovenian: • sladkorna bolezen s simptomi na ožilju,
English: There have been no reports of serious harmful effects from taking too many Zoely tablets at one time.
Slovenian: Če ste vzeli večji odmerek zdravila Zoely, kot bi smeli Ni nobenih poročil o resnih škodljivih učinkih zaradi zaužitja prevelikega števila tablet zdravila Zoely naenkrat.
English: • sweating, nausea, vomiting or dizziness;
Slovenian: • znojenje, siljenje na bruhanje (navzea), bruhanje ali omotica;
English: Heart attack
Slovenian: Srčni infarkt
English: Table: Risk factors for ATE Risk factor
Slovenian: Preglednica: Dejavniki tveganja za ATE Dejavnik tveganja
English: If any of the above conditions change while you are using Zoely, for example, you start smoking, a close family member experiences a thrombosis for no known reason or you gain a lot of weight, tell your doctor.
Slovenian: Zdravniku morate povedati, če se kaj od naštetega med vašo uporabo zdravila Zoely spremeni, na primer če začnete kaditi, če se kakšnemu bližnjemu sorodniku pojavi tromboza brez znanega razloga, ali če se močno zredite.
English: • Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum.
Slovenian: • Občasno se lahko pojavi kloazma, še posebej pri ženskah, ki imajo v anamnezi nosečnostno kloazmo.
English: Risk of venous thromboembolism (VTE)
Slovenian: Tveganje za vensko trombembolijo (VTE)
English: Eye disorders contact lens intolerance/dry eye
Slovenian: Očesne bolezni neprenašanje kontaktnih leč oz. suho oko
English: Throw away the yellow placebo tablet(s) you missed and continue taking the next tablets at the usual time.
Slovenian: Rumene placebo tablete, ki ste jih pozabili vzeti, vrzite stran in nadaljujte z jemanjem naslednjih tablet ob običajnem času.
English: • The herbal product St. John's wort may also stop Zoely from working properly.
Slovenian: • Tudi pripravki rastlinskega izvora, ki vsebujejo šentjanževko, lahko ovirajo pravilno delovanje zdravila Zoely.
English: However, if you have missed more than 1 tablet, use a barrier method such as a condom as an extra precaution until you have taken your tablets correctly for 7 days in a row.
Slovenian: Če pa ste izpustili več kot 1 tableto, uporabljajte pregradno metodo, na primer kondom, za dodatno zaščito, dokler ne boste tablet jemali pravilno 7 dni zaporedoma.
English: Nomegestrol acetate
Slovenian: Nomegestrolacetat
English: • Known or suspected sex steroid-influenced malignancies (e.g., of the genital organs or the breasts).
Slovenian: • Znane maligne bolezni ali sum nanje (npr. genitalnih organov ali dojk), zaradi vpliva steroidnih spolnih hormonov.
English: In all of these cases, the woman should be advised to additionally use a barrier method until she has completed 7 days of uninterrupted white active tablet-taking.
Slovenian: V vseh teh primerih ženski svetujte, da dodatno uporablja pregradno metodo kontracepcije, dokler ne zaključi 7-dnevnega obdobja neprekinjenega jemanja belih tablet z zdravilno učinkovino.
English: If you wish to use the pill while breast-feeding, please seek the advice of your doctor.
Slovenian: Če ga želite jemati tudi med dojenjem, se morate posvetovati z zdravnikom.
English: But if you are having intercourse, make sure you also use a barrier method of contraception for the first 7 days that you are taking Zoely.
Slovenian: Če pa imate spolne odnose, morate prvih 7 dni jemanja zdravila Zoely uporabljati tudi pregradno metodo kontracepcije.
English: • It is estimated that out of 10,000 women who use a levonorgestrel-containing CHC about 6
Slovenian: 1 od 10.000 žensk, ki uporabljajo CHC,
English: Reproductive system and breast disorders abnormal withdrawal bleeding metrorrhagia, menorrhagia, breast pain, pelvic pain hypomenorrhoea, breast swelling, galactorrhoea, uterine spasm, premenstrual syndrome, breast mass, dyspareunia, vulvovaginal dryness vaginal odour, vulvovaginal discomfort
Slovenian: Motnje reprodukcije in dojk nenormalne odtegnitvene krvavitve metroragija, menoragija, bolečine v dojkah, bolečine v medenici hipomenoreja, otekanje dojk, galaktoreja, krč maternice, predmenstrualni sindrom, bulica v dojkah, disparevnija, suhost vulve in nožnice izrazit vonj iz nožnice, neprijeten občutek v vulvi in nožnici
English: • During clinical trials with the Hepatitis C virus (HCV) combination drug regimen ombitasvir/paritaprevir/ritonavir with and without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN) were significantly more frequent in women using ethinylestradiol-containing medications such as CHCs.
Slovenian: • V kliničnih preskušanjih s kombinacijo učinkovin za zdravljenje okužbe z virusom hepatitisa C (HCV) ombitasvir/paritaprevir/ritonavir z dasabuvirjem ali brez je bilo zvišanje vrednosti ALT več kot 5-krat nad zgornjo mejo normalne vrednosti bistveno pogostejše pri ženskah, ki so jemale zdravila z etinilestradiolom, kot so na primer CHC.