FrancophonIA/ELRC3.0 huggingface dataset:
English: However, maternal exposure levels were considerably lower than those maximally reported in clinical setting (10-500 times lower than human AUC, 3-50 times lower than the human Cmax).
Slovenian: Vendar pa so bile ravni izpostavljenosti matere znatno nižje od najvišjih, poročanih v kliničnem okolju (10-500krat nižje kot AUC pri človeku, 3-50-krat nižje kot Cmax pri človeku).
English: MediWound Ltd. 42 Hayarkon St. 81227 Yavne Israel
Slovenian: MediWound Ltd. 42 Hayarkon St. 81227 Yavne Izrael
English: In vitro and animal data suggest that bromelain can also promote fibrinolysis.
Slovenian: Podatki pri živalih in vitro kažejo, da lahko bromelain spodbuja fibrinolizo.
English: This includes proper wound cover for the exposed tissue.
Slovenian: To vključuje pravilno prekrivanje ran pri izpostavljenem tkivu.
English: A second and subsequent application is not recommended.
Slovenian: Drugi in nadaljnji nanosi se ne priporočajo.
English: These medicines include, for example, sleep medications, so-called tranquilizers, some pain medications and antidepressants.
Slovenian: Ta zdravila lahko na primer vključujejo zdravila za spanje, tako imenovana pomirjevala, nekatera zdravila proti bolečinam in antidepresive.
English: Patients should be monitored for increased toxicity.
Slovenian: Bolnike je treba opazovati zaradi povečane toksičnosti.
English: In 4 patients, having received a dose of 5, 9, 12 and 17 g, respectively, there were indications of markedly higher systemic absorption.
Slovenian: Pri 4 bolnikih, ki so prejeli odmerke 5, 9, 12 oz. 17 g, so opazili znake značilno višje sistemske absorpcije.
English: Pyrexia/hyperthermia*
Slovenian: pireksija/hipertermija*
English: Bromelain may enhance the hypotensive effect of ACE inhibitors, causing larger decreases in blood pressure than expected.
Slovenian: Bromelain lahko okrepi hipotenzivni učinek zaviralcev ACE, kar povzroči večji padec krvnega tlaka, kot je pričakovano.
English: Very common side effects (may affect more than 1 in 10 people) - Fever
Slovenian: Zelo pogosti neželeni učinki (prizadenejo lahko več kot 1 od 10 bolnikov) - povišana telesna temperatura
English: Sensitisation may have occurred due to inhalation of bromelain powder.
Slovenian: Sensibilizacija se je lahko pojavila zaradi vdihavanja praška bromelaina.
English: If you are not sure whether you are taking any of the medicines mentioned above, ask your doctor before NexoBrid is used.
Slovenian: Če niste prepričani, ali uporabljate katerega od zgoraj navedenih zdravil, se pred uporabo zdravila NexoBrid posvetujte s svojim zdravnikom.
English: • NexoBrid should not be applied to more than 15% (one eighth) of the total body surface.
Slovenian: • Zdravila NexoBrid se ne sme nanesti na več kot 15 % (ena osmina) celotne površine telesa naenkrat.
English: Bromelain may enhance the actions of fluorouracil and vincristine.
Slovenian: Bromelain lahko okrepi delovanje fluorouracila in vinkristina.
English: ** Informed Consent Form
Slovenian: ** Obrazec prostovoljnega soglasja
English: NexoBrid (2 g/100 cm 2, corresponding to 0.02 g/cm 2) was used as described in section 4.2.
Slovenian: Zdravilo NexoBrid (2 g/100 cm 2, kar ustreza 0,02 g/cm 2) so uporabili, kot je opisano v poglavju 4.2.
English: Remaining antibacterial medicinal products may interfere with the activity of NexoBrid by decreasing its efficacy.
Slovenian: Preostala antibakterijska zdravila lahko vplivajo na aktivnost zdravila NexoBrid in zmanjšajo njegovo učinkovitost.
English: The safety and efficacy of NexoBrid in children and adolescents younger than 18 years have not yet been established.
Slovenian: Varnost in učinkovitost zdravila NexoBrid pri otrocih in mladostnikih, mlajših od 18 let, še nista bili dokazani.
English: Hypersensitivity reactions, skin exposure
Slovenian: Preobčutljivostna reakcija, izpostavljenost kože
English: An asterisk (*) indicates that additional information on the respective adverse reaction is provided below the list of adverse reactions.
Slovenian: Zvezdica (*) pomeni, da so za seznamom neželenih učinkov za ta neželeni učinek spodaj navedeni dodatni podatki.
English: These results for Cmax and AUClast indicate that systemic absorption may depend both on the applied NexoBrid dose (proportional to the covered wound area) and other, patient-specific factors.
Slovenian: Ti rezultati za Cmax in AUClast kažejo, da je morda sistemska absorpcija odvisna od uporabljenega odmerka zdravila NexoBrid (sorazmerno s prekrito opeklinsko rano) in od drugih dejavnikov, specifičnih za bolnika.
English: There are reports of occupational exposure to bromelain leading to sensitisation.
Slovenian: Obstajajo poročila o poklicni izpostavljenosti bromelainu, ki je povzročila senzibilizacijo.
English: • OBLIGATION TO CONDUCT POST-AUTHORISATION MEASURES The MAH shall complete, within the stated timeframe, the following measures:
Slovenian: • OBVEZNOSTI IZVEDBE UKREPOV PO PRIDOBITVI DOVOLJENJA ZA PROMET Imetnik dovoljenja za promet z zdravilom mora v določenem časovnem okviru izvesti naslednje ukrepe:
English: Efficacy data generated in this study from a subgroup analysis for children and adolescents are summarised below.
Slovenian: Podatki o učinkovitosti iz te študije, nastali z analizo podskupin za otroke in mladostnike, so povzeti spodaj.
English: The PSUR cycle for the medicinal product should follow the standard requirements until otherwise agreed by the CHMP.
Slovenian: PSUR Cikel PSUR za zdravilo mora slediti standardnim zahtevam, dokler CHMP ne odloči drugače.
English: The Marketing Authorisation Holder (MAH) should ensure that, at launch, all Healthcare Professionals in specialist burn centres who are expected to use and/or prescribe NexoBrid receive a specific training and are provided with an Educational pack.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da bodo ob prihodu zdravila na trg vsi zdravstveni delavci v specializiranih centrih za opekline, za katere se pričakuje, da bodo uporabljali in/ali predpisovali zdravilo NexoBrid, deležni ustreznega izobraževanja in prejeli izobraževalni paket.
English: NexoBrid must be used with caution in such patients.
Slovenian: Zdravilo NexoBrid morate pri takih bolnikih uporabiti previdno.
English: Do not use NexoBrid after the expiry date which is stated on the label of the vial, bottle, and box after “EXP”.
Slovenian: Zdravila NexoBrid ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki viale, steklenice in škatle poleg oznake "EXP".
English: Pyrexia/hyperthermia
Slovenian: Pireksija/hipertermija
English: In case of skin exposure, NexoBrid should be rinsed off with water to reduce the likelihood of skin sensitisation (see section 6.6).
Slovenian: V primeru izpostavljenosti kože je treba zdravilo NexoBrid izprati z vodo, da se zmanjša možnost senzibilizacije kože (glejte poglavje 6.6).
English: Your doctor will be cautious and watch for signs of reduced blood coagulation or bleeding when prescribing other medicines that affect blood coagulation, because NexoBrid may reduce blood coagulation.
Slovenian: Vaš zdravnik bo previden in bo opazoval znake zmanjšanega strjevanja krvi ali krvavitev, ko predpisuje druga zdravila, ki vplivajo na strjevanje krvi, saj lahko zdravilo NexoBrid zmanjša strjevanje krvi.
English: NexoBrid must not be used: - if you are allergic to bromelain - if you are allergic to pineapples - if you are allergic to papain - if you are allergic to any of the other ingredients of the powder or gel (listed in section 6).
Slovenian: Zdravila NexoBrid ne smete uporabljati: - če ste alergični na bromelain - če ste alergični na ananas - če ste alergični na papain - če ste alergični na katero koli sestavino praška ali gela (navedeno v poglavju 6).
English: • The fact that NexoBrid may cause an allergic reaction, an increased tendency to bleed and severe local irritation and that patients should be monitored for signs or symptoms of these
Slovenian: • Dejstvo, da lahko zdravilo Nexobrid povzroči alergijsko reakcijo, večjo nagnjenost h krvavitvam in hudo lokalno draženje, in da je treba bolnike spremljati za pojav takih znakov in simptomov
English: • The wound assessment and the warning against any repeat treatment
Slovenian: • Ocena rane in opozorilo pred ponovnim zdravljenjem
English: The major constituent is stem bromelain.
Slovenian: Glavna sestavina je bromelain.
English: Caution and monitoring is therefore needed when prescribing concomitant medicinal products that affect coagulation.
Slovenian: Zato sta pri sočasni uporabi zdravil, ki vplivajo na koagulacijo, potrebna previdnost in spremljanje.
English: • Healthcare Professional information pack
Slovenian: • Izobraževalni paket za zdravstvene delavce
English: Prior to launch in each Member State, the Marketing Authorisation Holder MAH shall agree the content and format of the educational programme with the national competent authority.
Slovenian: Pred prihodom zdravila na trg v vsaki državi članici se mora imetnik dovoljenja za promet z zdravilom z nacionalnim pristojnim organom dogovoriti o vsebini in obliki izobraževalnega programa.
English: The most commonly reported adverse reactions of the use of NexoBrid are local pain and transient pyrexia/hyperthermia.
Slovenian: Neželeni učinki, o katerih so najpogosteje poročali pri uporabi zdravila NexoBrid, so lokalna bolečina in prehodna pireksija/hipertermija.
English: In embryo-foetal development studies in rats and rabbits, intravenously administered NexoBrid revealed no evidence of indirect and direct toxicity to the developing embryo/foetus.
Slovenian: V razvojnih študijah embria-zarodka pri podganah in kuncih intravensko dajanje zdravila NexoBrid ni pokazalo nobenih znakov posredne ali neposredne toksičnosti za razvoj embria ali zarodka.
English: Coagulopathy
Slovenian: Koagulopatija
English: The European Medicines Agency has deferred the obligation to submit the results of studies with NexoBrid in one or more subsets of the paediatric population in the treatment of burns of external body surface (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila obvezo za predložitev rezultatov študij z zdravilom NexoBrid za eno ali več podskupin pediatrične populacije za zdravljenje opeklin zunanje površine telesa (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: NexoBrid showed no genotoxic activity when investigated in the standard set of in vitro and in vivo studies.
Slovenian: Zdravilo NexoBrid ni pokazalo genotoksične aktivnosti pri raziskavah v standardnem nizu študij in vitro in in vivo.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V
Slovenian: Od zdravstvenih delavcev se zahteva, da poročajo o katerem koli domnevnem neželenem učinku zdravila na nacionalni center za poročanje, ki je naveden v Prilogi V
English: This is to make it less likely that you develop an allergic reaction to NexoBrid.
Slovenian: To je potrebno, da se zmanjša verjetnost razvoja alergijske reakcije na zdravilo NexoBrid.
English: - If you have any further questions, ask your doctor.
Slovenian: - Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom.
English: Efficacy data generated in this study for all age groups combined as well as from a subgroup analysis for children and adolescents are summarised below.
Slovenian: Podatki o učinkovitosti za to študijo za vse starostne skupine skupaj in za analize podskupin za otroke in mladostnike so povzeti spodaj.
English: The MAH should undertake a controlled distribution of NexoBrid to ensure that the product is not available for use at a centre until at least one surgeon at the centre has received formal training in the use of NexoBrid.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora za zdravilo NexoBrid izvajati sistem nadzorovane distribucije, da zagotovi, da zdravilo v centru ne bo na voljo, dokler vsaj en kirurg iz tega centra ne opravi formalnega izobraževanja o uporabi zdravila NexoBrid.
English: • The limitation of the total area than can be treated to 15% TBSA
Slovenian: • Omejitev skupne površine, ki jo je dovoljeno zdraviti, je 15 % CPT
English: In several cases adequate healing did not occur and autografting was required at a later date, leading to significant delays in wound closure which is associated with increased risk of wound-related complications.
Slovenian: V številnih primerih ni prišlo do ustrezne zacelitve, zato je bilo kasneje predel treba prekriti z avtotransplantatom, kar je znatno upočasnilo zapiranje rane, ki je povezano z večjim tveganjem za zaplete, povezane z rano.
English: After treatment with NexoBrid your doctor may check your blood coagulation levels.
Slovenian: Po zdravljenju z zdravilom NexoBrid lahko vaš zdravnik preveri, kako se vaša kri strjuje.
English: The MAH shall conducts a study on enzymatic debridement in burns patients (children and adults): A comparison to standard of care (protocol MW2010-0302), based on a CHMP approved protocol.
Slovenian: Imetnik dovoljenja za promet z zdravilom bo opravil študijo encimskega čiščenja ran pri bolnikih z opeklinami (otroci in odrasli): Primerjava s standardno nego (protokol MW2010-03-02), na podlagi protokola, ki ga je odobril CHMP.
English: Pharmacotherapeutic group: Preparations for treatment of wounds and ulcers, proteolytic enzymes; ATC code: D03BA03
Slovenian: Farmakoterapevtska skupina: pripravki za zdravljenje ran in razjed, proteolitični encimi; oznaka ATC: D03BA03
English: NexoBrid powder (vial)
Slovenian: NexoBrid prašek (viala)
English: The comparisons in mixed wounds should be interpreted with caution since they are based on groups that are not fully randomized and the mixed wounds treated by NexoBrid were overall larger and had a larger full thickness area.
Slovenian: Primerjavo mešanih ran je treba razlagati previdno, saj temeljijo na skupinah, ki niso povsem randomizirane; mešane rane, zdravljene z zdravilom NexoBrid pa so bile na splošno večje in so imele večje prizadete subdermalne predele.
English: • The need for pain management
Slovenian: • Potreba po protibolečinskemu zdravljenju
English: The potential of NexoBrid (a protein product) to cause sensitisation should be taken into account when re-exposing patients to bromelain-containing products at a later point in time.
Slovenian: Potencial zdravila NexoBrid (beljakovinski izdelek), da povzroči senzibilizacijo, je treba upoštevati pri ponovni kasnejši izpostavitvi bolnikov izdelkom, ki vsebujejo bromelain.
English: This should be taken into account when dosing such products.
Slovenian: To je treba upoštevati pri odmerjanju teh zdravil.
English: If there is a risk of eye contact, the patient's eyes should be protected with fatty ophthalmic ointment.
Slovenian: Če obstaja tveganje za stik z očmi, morate bolnikove oči zaščititi z mastnim oftalmičnim mazilom.
English: The age range in the group treated with NexoBrid was 4.4 to 55.7 years.
Slovenian: Razpon starosti v skupini, zdravljeni z zdravilom NexoBrid, je bil 4,4 do 55,7 let.
English: Bromelain may increase drowsiness caused by some medicinal products (e.g., benzodiazepines, barbiturates, narcotics and antidepressants).
Slovenian: Bromelain lahko poveča zaspanost, ki jo povzročijo nekatera zdravila (npr. benzodiazepini, barbiturati, narkotiki in antidepresivi).
English: NexoBrid serum concentrations were determined using a modified sandwich electrochemiluminescence (ECL) immunoassay.
Slovenian: Koncentracije zdravila NexoBrid v serumu so določali z modificiranim elektrokemiluminescentnim (ECL) sendvič-imunotestom.
English: The MAH shall perform the pharmacovigilance activities detailed in the Pharmacovigilance Plan, as agreed in the Risk Management Plan presented in Module 1.8.2. of the Marketing Authorisation and any subsequent updates of the RMP agreed by the Committee for Medicinal Products for Human Use (CHMP).
Slovenian: Imetnik dovoljenja za promet z zdravilom bo izvedel farmakovigilančne aktivnosti, podrobno opisane v načrtu farmakovigilance, sprejetem v RMP, predloženem v modulu 1.8.2 dovoljenja za promet z zdravilom, in vseh nadaljnjih posodobitvah RMP v soglasju z Odborom za zdravila za uporabo v humani medicini (CHMP).
English: Hypersensitivity to the active substance, to pineapples or papain (see also section 4.4), or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na zdravilno učinkovino, ananas ali papain (glejte tudi poglavje 4.4), ali katero koli pomožno snov, navedeno v poglavju 6.1.
English: NexoBrid, when absorbed, is an inhibitor of cytochrome P 450 2C8 (CYP2C8) and P450 2C9 (CYP2C9).
Slovenian: Ko se zdravilo NexoBrid absorbira, je zaviralec citokroma P 450 2C8 (CYP2C8) in P 450 2C9 (CYP2C9).
English: • The risk of allergic reaction and of cross reactivity and the contraindication in patients allergic to pineapple and papain or to previous application of the product
Slovenian: • Tveganje za pojav alergijskih reakcij in navzkrižnih reakcij ter kontraindikacije pri bolnikih, alergičnih na ananas in papain ali na predhodni nanos zdravila
English: During the clinical development of NexoBrid, there was no indication of an increased bleeding tendency or bleeding at the site of debridement.
Slovenian: Med kliničnim razvojem zdravila NexoBrid ni bilo znakov povečane nagnjenosti h krvavitvam ali krvavitve na mestu čiščenja.
English: Powder and gel to be mixed before application.
Slovenian: Prašek in gel je treba pred uporabo premešati.
English: What you need to know before NexoBrid is used
Slovenian: Kaj morate vedeti, preden se uporabi zdravilo NexoBrid
English: A Cmax of 40µg/ml may be possible in humans administered NexoBrid under licensed conditions, when it is considered that PK has only been evaluated in patients with largely superficial burns, receiving half the maximum dose.
Slovenian: Cmax 40 µg/ml je lahko mogoč pri osebah, ki prejmejo zdravilo NexoBrid v okviru pogojev odobrene uporabe, pri čemer se upošteva, da je bila farmakokinetika ocenjena le pri bolnikih z velikimi površinskimi opeklinami, ki so prejeli polovični največji odmerek.
English: What NexoBrid is and what it is used for
Slovenian: Kaj je zdravilo NexoBrid in za kaj ga uporabljamo
English: According to a literature report, in plasma, approximately 50% of bromelain binds to the human plasma antiproteinases α2-macroglobulin and α1-antichymotrypsin.
Slovenian: V literaturi poročajo, da se v plazmi približno 50 % bromelaina veže na antiproteazi α2-makroglobulin in α1-antihimotripsin v plazmi pri človeku.
English: During clinical development, a total of 362 patients were treated with the concentrate of proteolytic enzymes enriched in bromelain.
Slovenian: Med kliničnim razvojem so skupaj 362 bolnikov zdravili s koncentratom proteolitičnih encimov, obogatenih z bromelainom.
English: This is because NexoBrid can be absorbed from the burn wound into the blood stream.
Slovenian: To je zato, ker se lahko zdravilo NexoBrid absorbira iz opeklin v krvni obtok.
English: PHARMACEUTICAL FORM AND CONTENT
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA
English: The MAH must ensure that the system of pharmacovigilance presented in Module 1.8.1. of the Marketing Authorisation is in place and functioning before and whilst the medicinal product is on the market.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da je sistem farmakovigilance, predložen v modulu 1.8.1 dovoljenja za promet z zdravilom, vzpostavljen in deluje, preden da zdravilo v promet in ves čas trženja zdravila.
English: The extent of systemic absorption from a burn wound, Cmax, Tmax, AUC, and t½ of bromelain from NexoBrid have been investigated in 16 burn patients with partial-thickness (mid- and deep-dermal) thermal burns.
Slovenian: Obseg sistemske absorpcije iz opeklinske rane, Cmax, Tmax, AUC in t½ bromelaina iz zdravila NexoBrid so raziskali pri 16 bolnikih z dermalnimi (srednjimi in globokimi) opeklinskimi ranami.
English: 48 wounds
Slovenian: 48 ran
English: • The dressing must remain in place for 4 hours.
Slovenian: • Obloga mora ostati na rani 4 ure.
English: 60 wounds
Slovenian: 60 ran
English: Therefore, wounds with areas of full-thickness and deep burn should be autografted as soon as possible after NexoBrid debridement (see section 5.1 for study results).
Slovenian: Zato je treba subdermalne in globoke opekline po čiščenju z zdravilom NexoBrid prekriti z avtotransplantatom takoj, ko je možno (za rezultate študije glejte poglavje 5.1).
English: Concentrate of proteolytic enzymes enriched in bromelain is systemically absorbed from burn wound areas (see section 5.2).
Slovenian: Koncentrat proteolitičnih encimov, obogaten z bromelainom, se sistemsko absorbira iz območja opeklinske rane (glejte poglavje 5.2).
English: Terminal half-life (determined using data from 16 to 48 hours post-dose for 12 patients) was 11.7 ± 3.5 hours (mean ± SD), with a range from 8.5 to 19.9 hours.
Slovenian: Končni razpolovni čas (ugotovljen s podatki iz 16 do 48 ur po odmerku za 12 bolnikov) je bil 11,7 ± 3,5 ure (povprečje ± SD), z razponom od 8,5 do 19,9 ure.
English: D-48155 Münster Germany
Slovenian: D-48155 Münster Nemčija
English: General Infections
Slovenian: Splošne okužbe
English: <Not applicable.>
Slovenian: <Navedba smiselno ni potrebna.>
English: Standard of care consisted of primary surgical excision and/or nonsurgical debridement using topical medicinal products to induce maceration and autolysis of eschar according to each study site's standard practice.
Slovenian: Standardna nega je bila primarna kirurška ekscizija in/ali nekirurško čiščenje s topikalnimi zdravili za induciranje maceracije in avtolize eshar v skladu s standardno prakso vsake lokacije študije.
English: Repeated intravenous injections of doses up to 12 mg/kg every third day in the mini-pig were well tolerated for the first three injections but severe clinical signs of toxicity (e.g. haemorrhages in several organs) were observed following the remaining three injections.
Slovenian: Ponavljajoče se intravensko injiciranje odmerkov do 12 mg/kg vsak tretji dan so mini-prašički dobro prenašali prve tri injekcije, nato pa so pri ostalih treh injekcijah opazili hude klinične znake toksičnosti (npr. krvavitev številnih organov).
English: • The wound must then be covered with a sterile occlusive film dressing that adheres to the sterile adhesive barrier material applied as per the instruction above (see Preparation of patient and wound area).
Slovenian: • Rano morate nato prekriti s sterilno okluzivno filmsko oblogo, ki se zalepi na sterilni adhezivni pregradni material, nanesen v skladu z navodili zgoraj (glejte Priprava bolnika in predela rane).
English: The effect on the timing of eschar removal was evaluated in patients with successful eschar removal (with at least 90% eschar removal in all wounds of a patient combined), by determining the time from injury as well as from informed consent to successful removal.
Slovenian: Učinek na čas odstranitve eshar so ocenili pri bolnikih z uspešno odstranitvijo eshar (z vsaj 90odstotno odstranitvijo eshar v vseh ranah bolnika skupaj), z določitvijo časa od poškodbe in od zavestnega soglasja za uspešno odstranitev.
English: Serious allergic reactions including anaphylaxis
Slovenian: resne alergijske reakcije, vključno z anafilakso
English: NexoBrid gel preparation (mixing powder with gel)
Slovenian: Priprava zdravila NexoBrid gel (mešanje praška z gelom)
English: The proteolytic enzymes are a mixture of enzymes from the stem of Ananas comosus (pineapple plant).
Slovenian: Proteolitični encimi so mešanica encimov iz stebla rastline Ananas comosus (rastlina ananasa).
English: Immune system disorders Not known:
Slovenian: lokalna bolečina* Bolezni imunskega sistema Neznana:
English: What NexoBrid is and what it is used for What you need to know before NexoBrid is used How NexoBrid is used
Slovenian: Kaj je zdravilo NexoBrid in za kaj ga uporabljamo Kaj morate vedeti, preden se uporabi zdravilo NexoBrid Kako se uporablja zdravilo NexoBrid Možni neželeni učinki
English: This usually requires mixing the powder and the gel for 1 to 2 minutes.
Slovenian: Običajno je treba prašek in gel mešati 1 do 2 minuti.