FrancophonIA/ELRC3.0 huggingface dataset:
English: Rare, may affect up to 1 in 1,000 people • severe skin rash with or without blisters and fever
Croatian: Rijetko, mogu se pojaviti u do 1 na 1000 osoba • težak osip kože s plikovima i vrućicom ili bez njih
English: Two-week oral toxicity studies were conducted in juvenile rats and rabbits, and a four-week IV toxicity study was conducted in juvenile rats.
Croatian: Ispitivanja oralne toksičnosti u trajanju od dva tjedna provedena su na mladunčadi štakora i kunića, a ispitivanje intravenske toksičnosti u trajanju od četiri tjedna provedeno je na mladunčadi štakora.
English: Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza.
Croatian: Ozbiljne bakterijske infekcije mogu u početku imati simptome slične gripi ili mogu biti prisutne zajedno s gripom ili se pojaviti kao njezina komplikacija.
English: • prolonged time of the heart ventricle activity, measured in the ECG
Croatian: • produljeno vrijeme aktivnosti srčane klijetke, mjereno na EKG-u
English: Seqirus Vaccines Ltd Gaskill Road Speke
Croatian: Seqirus Vaccines Ltd Gaskill Road
English: At enrollment 85 % of the 296 subjects had a composite influenza symptom score <15.
Croatian: Pri uključivanju u ispitivanje 85 % od 296 ispitanika imalo je ukupan rezultat simptoma gripe <15.
English: What Alpivab is and what it is used for
Croatian: Što je Alpivab i za što se koristi
English: Alpivab is a clear, colourless, sterile concentrate for solution for infusion.
Croatian: Alpivab je bistar, bezbojan, sterilan koncentrat za otopinu za infuziju.
English: There are insufficient clinical data available in children and adolescents aged less than 13 years or with body weight less than 50 kg with renal impairment to be able to make any dosing recommendation.
Croatian: Nisu dostupni dostatni klinički podaci za djecu i adolescente mlađe od 13 godina ili s tjelesnom težinom manjom od 50 kg s oštećenjem funkcije bubrega kako bi se mogla dati preporuka za doziranje.
English: Carcinogenicity studies by intravenous injection of peramivir were not performed.
Croatian: Ispitivanja kancerogenosti intravenskom injekcijom peramivira nisu provedena.
English: • Check the seal of each vial.
Croatian: • Provjerite pokrov svake bočice.
English: Children and Adolescents from 2 years Side effects were similar to adults but also included the following: Common, may affect up to 1 in 10 people
Croatian: Nuspojave su bile slične onima u odraslih, no uključivale su i sljedeće: Često, mogu se pojaviti u do 1 na 10 osoba
English: Your doctor will advise on whether you can be given Alpivab during pregnancy, or whether you are to stop breast-feeding for a short period after getting Alpivab.
Croatian: Liječnik će vas savjetovati o tome možete li primiti Alpivab za vrijeme trudnoće ili trebate li kratkoročno prekinuti dojenje nakon primjene lijeka Alpivab.
English: • abnormal behaviour, delirium
Croatian: • neuobičajeno ponašanje, delirij
English: The mean temperature at enrolment was 38.6 °C (axillary).
Croatian: Srednja vrijednost temperature pri uključivanju u ispitivanje iznosila je 38,6 °C (ispod pazuha).
English: SPECIAL STORAGE CONDITIONS Do not refrigerate or freeze.
Croatian: POSEBNE MJERE ČUVANJA Ne odlagati u hladnjak ili zamrzavati.
English: Alpivab is indicated for the treatment of uncomplicated influenza in adults and children from the age of 2 years (see sections 4.4 and 5.1).
Croatian: Alpivab je indiciran za liječenje nekomplicirane gripe u odraslih i djece u dobi od dvije godine i više (vidjeti dijelove 4.4 i 5.1).
English: • low levels of a white blood cell type called neutrophils
Croatian: • niske razine vrste bijelih krvnih stanica pod nazivom neutrofili
English: Available data do not support a conclusion that peramivir is effective in patients with influenza B or in patients with complicated influenza.
Croatian: Dostupni podaci ne idu u prilog zaključku da je peramivir djelotvoran u bolesnika s virusom gripe tipa B ili u bolesnika s kompliciranom gripom.
English: Alpivab is used to treat adults and children aged from 2 years with influenza that is not severe enough to require hospitalisation.
Croatian: Alpivab se primjenjuje za liječenje odraslih i djece u dobi od 2 ili više godina oboljelih od gripe koja nije toliko ozbiljna da bi bilo potrebno bolničko liječenje.
English: Subjects participating in the trial were required to self-assess their influenza symptoms as “none', ‘mild', ‘moderate' or ‘severe' twice daily.
Croatian: Od ispitanika koji su sudjelovali u ispitivanju zahtijevalo se da dvaput dnevno samostalno procijene svoje simptome, i to kao: „nisu prisutni”, „blagi”, „umjereni” ili „teški”.
English: • severe allergic reactions, including severe allergic shock reaction with features such as itchy rash, swelling of the throat and tongue, breathing difficulty, lightheadedness and vomiting
Croatian: • teške alergijske reakcije, uključujući tešku alergijsku reakciju šoka sa značajkama kao što su osip praćen svrbežom, oticanje grla i jezika, otežano disanje, ošamućenost i povraćanje
English: • rash on the injection site
Croatian: • osip na mjestu injiciranja
English: Other side effects occur with the following frequencies:
Croatian: Ostale nuspojave pojavljuju se sa sljedećom učestalošću:
English: The major route of elimination of peramivir is via the kidney.
Croatian: Glavni način eliminacije peramivira je putem bubrega.
English: Marketing Authorisation Holder BioCryst Ireland Limited Atlantic Avenue
Croatian: Nositelj odobrenja za stavljanje lijeka u promet BioCryst Ireland Limited Atlantic Avenue
English: Do not use if the seal opening is broken or missing.
Croatian: Ne upotrebljavajte proizvod ako je pokrov neispravan ili ga nema.
English: The efficacy of peramivir as a single dose treatment for uncomplicated influenza was demonstrated in a single placebo-controlled study conducted in 300 adult patients in Japan during the 2007/2008 influenza season.
Croatian: Djelotvornost peramivira u liječenju nekomplicirane gripe primjenom jednokratne doze dokazana je u jednom placebom kontroliranom ispitivanju provedenom na 300 odraslih bolesnika u Japanu tijekom sezone gripe 2007./2008.
English: Most of the cases occurred in elderly patients with comorbidities and multiple concomitant medicinal products.
Croatian: Većina slučajeva zabilježena je u starijih bolesnika s komorbiditetima i pri istodobnoj primjeni više lijekova.
English: Children aged from 2 years and <50 kg
Croatian: Djeca u dobi od dvije ili više godina i <50 kg
English: Do not mix or co-infuse Alpivab with other medicines administered into a vein.
Croatian: Alpivab ne miješajte niti ga stavljajte u istu infuziju s drugim lijekovima koji se daju u venu.
English: Manufacturer Seqirus Vaccines Limited Gaskill Road, Speke Liverpool
Croatian: Seqirus Vaccines Limited Gaskill Road, Speke Liverpool
English: Talk to your doctor or pharmacist before you are given Alpivab if you have reduced kidney function.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego što primite Alpivab ako imate smanjenu funkciju bubrega.
English: What you need to know before you are given Alpivab
Croatian: Što morate znati prije nego što primite Alpivab
English: Patients with influenza should be closely monitored for signs of abnormal behaviour.
Croatian: Bolesnike oboljele od gripe potrebno je pomno promatrati kako bi se uočili znakovi neuobičajenog ponašanja.
English: Intravenous use after dilution
Croatian: Intravenska primjena nakon razrjeđivanja
English: Time to recovery of normal temperature median (hours) (95 % CI)
Croatian: Medijan vremena potrebnog za ponovno postizanje normalne temperature (sati) (95 % CI)
English: • Adults and adolescents (13 years and older) receive 600 mg (3 Alpivab vials).
Croatian: • Odrasli i adolescenti (13 godina i više) primaju 600 mg (3 bočice Alpivaba).
English: The H275Y substitution is associated with reduced susceptibility to peramivir and oseltamivir.
Croatian: Supstitucija H275Y povezana je sa smanjenom osjetljivosti na peramivir i oseltamivir.
English: The mean AUC0- was increased by 28 %, 302 % and 412 % in subjects with creatinine clearance of 50-79, 30-49 and 10-29 mL/min, respectively.
Croatian: Srednja vrijednost AUC0- povećana je za 28 %, 302 % i 412 % u ispitanika s vrijednosti klirensa kreatinina od 50-79, 30-49 i 10-29 ml/min.
English: The pharmacokinetic parameters following intravenous (IV) administration of peramivir (0.17 to 2 times the recommended dose) showed a linear relationship between dose and exposure parameters (maximum serum concentration [Cmax] and area under the curve [AUC]).
Croatian: Farmakokinetički parametri nakon intravenske (i.v.) primjene peramivira (od 0,17 do 2 puta veće od preporučene doze) pokazali su linearan odnos između parametara doze i izloženosti (najveća koncentracija u serumu [Cmax] i područje ispod krivulje [AUC]).
English: The intent to treat influenza population (ITTI) included 296 subjects with influenza confirmed by polymerase chain reaction (PCR).
Croatian: Populacija koju se namjeravalo liječiti od gripe (engl. intent to treat influenza, ITTI) obuhvaćala je 296 ispitanika s gripom koja je potvrđena lančanom reakcijom polimeraze (PCR).
English: If any hypersensitivity reaction occurs during infusion of peramivir, the infusion must be stopped immediately and appropriate management should be instituted.
Croatian: Ako tijekom infuzije peramivira dođe do reakcije preosjetljivosti, potrebno je odmah prekinuti infuziju i uvesti odgovarajuće mjere.
English: Common, may affect up to 1 in 10 people
Croatian: Često, mogu se pojaviti u do 1 na 10 osoba
English: • The active substance is peramivir.
Croatian: • Djelatna tvar je peramivir.
English: Renal clearance of unchanged peramivir accounts for approximately 90 % of total clearance.
Croatian: Bubrežni klirens nepromijenjenog peramivira iznosi približno 90 % ukupnog klirensa.
English: AUClast (ng•h/mL)
Croatian: (ng•h/ml)
English: There is no evidence for efficacy of peramivir in any illness caused by agents other than influenza viruses.
Croatian: Nema dokaza o djelotvornosti peramivira u bilo kojoj drugoj bolesti prouzročenoj tvarima koje nisu virusi gripe.
English: • Discard any unused diluted solution of peramivir after 24 hours.
Croatian: • Neiskorištenu razrijeđenu otopinu peramivira bacite nakon 24 sata.
English: Time to alleviation of symptoms median (hours) (95 % CI)
Croatian: Medijan vremena potrebnog za ublažavanje simptoma (sati) (95 % CI)
English: Alpivab is given by a healthcare profesional as a single dose within 2 days of the start of influenza symptoms.
Croatian: Alpivab primjenjuje zdravstveni radnik u jednokratnoj dozi unutar dva dana od početka simptoma gripe.
English: 10 to 29
Croatian: 300 mg od 10 do 29
English: Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3).
Croatian: Ispitivanja na životinjama ne upućuju na izravne ili neizravne štetne učinke u pogledu reproduktivne toksičnosti (vidjeti dio 5.3).
English: The dose should be reduced for adults and adolescents (13 years and older) with absolute glomerular filtration rate (GFR) below 50 mL/min as shown in Table 2 (see sections 4.4 and 5.2).
Croatian: Dozu treba smanjiti za odrasle i adolescente (13 godina i više), s apsolutnom brzinom glomerularne filtracije (GFR) manjom od 50 ml/min, kao što je prikazano u tablici 2 (vidjeti dijelove 4.4 i 5.2).
English: Fractions of a vial may be needed for appropriate dose adjustments in children with a bodyweight of less than 50 kg.
Croatian: Frakcije bočice mogu biti potrebne za odgovarajuću prilagodbu doze u djece s tjelesnom težinom manjom od 50 kg.
English: Patients with influenza and already existing diseases should be closely monitored for renal function.
Croatian: U bolesnika oboljelih od gripe i s već postojećim bolestima potrebno je pomno pratiti funkciju bubrega.
English: Subjects were eligible if they had fever greater than 38 °C and a positive rapid antigen test for influenza virus, accompanied by at least two of the following symptoms: cough, nasal symptoms, sore throat, myalgia, chills/sweats, malaise, fatigue or headache.
Croatian: Ispitanici su ispunjavali uvjete ako su imali vrućicu veću od 38 °C i pozitivan brzi test za dokazivanje antigena virusa gripe, uz barem dva sljedeća simptoma: kašalj, nazalne simptome, grlobolju, mialgiju, zimicu/znojenje, malaksalost, umor ili glavobolju.
English: Among 467 adult subjects with uncomplicated influenza who received a single intravenous dose of peramivir 600 mg in clinical trials, the most commonly observed adverse reactions were neutrophil count decreased (3.2 %) and nausea (2.4 %).
Croatian: Od 467 odraslih ispitanika s nekompliciranom gripom koji su primili jednokratnu intravensku dozu od 600 mg peramivira u kliničkim ispitivanjima, najčešće uočene nuspojave bile su smanjenje broja neutrofila (3,2 %) i mučnina (2,4 %).
English: The pharmacokinetics in elderly subjects was similar to non-elderly subjects.
Croatian: Farmakokinetika u starijih ispitanika bila je slična farmakokinetici u ispitanika koji nisu starije dobi.
English: Subjects receiving peramivir experienced a median time to alleviation of their combined influenza symptoms of 79.0 hours and the median time to recovery to normal temperature (less than 37 °C) was approximately 40.0 hours.
Croatian: U ispitanika koji su primali peramivir medijan vremena do ublažavanja kombiniranih simptoma gripe iznosio je 79,0 sati, a medijan vremena do ponovnog postizanja normalne temperature (niže od 37 °C) iznosio je približno 40,0 sati.
English: Peramivir was not teratogenic in embryo-fetal development studies in rats and rabbits and had no effects on mating or fertility in rats up to 600 mg/kg/day, at which exposures were approximately 8-fold of those in humans at the clinically recommended dose.
Croatian: Peramivir se nije pokazao teratogenim u ispitivanjima embrio-fetalnog razvoja provedenima na štakorima i kunićima i nije imao učinak na parenje ili plodnost u štakora u dozi do 600 mg/kg/dan, pri čemu je izloženost bila približno osam puta veća od izloženosti u ljudi pri klinički preporučenoj dozi.
English: Tell your doctor immediately if you experience serious skin or allergic reactions after Alpivab is given.
Croatian: Odmah obavijestite svog liječnika ako primijetite ozbiljne reakcije na koži ili alergijske reakcije nakon primjene lijeka Alpivab.
English: In a clinical trial, no statistically significant clinical benefit could be demonstrated for peramivir over placebo in patients infected with the A/H1N1 virus containing the H275Y mutation.
Croatian: U kliničkom se ispitivanju nije mogla dokazati ni jedna statistički značajna klinička korist peramivira u odnosu na placebo u bolesnika zaraženih virusom gripe tipa A/H1N1 koji sadržava mutaciju H275Y.
English: These events were reported primarily among paediatric patients and often had an abrupt onset and rapid resolution.
Croatian: Ti su događaji zabilježeni ponajprije među pedijatrijskim bolesnicima te je često došlo do njihova naglog nastanka i brzog prestanka.
English: • increased level of urine ketone body
Croatian: • povišena razina ketonskih tijela u mokraći
English: In simulations of a single dose of 600 mg, the predicted AUC in Asians (AUC0-24 88,800 ng•h/mL) was slightly higher as compared to Non-Asians (AUC0-24 77,200 ng•h/mL).
Croatian: U simulacijama jednokratne doze od 600 mg predviđeni AUC u bolesnika Azijaca (AUC0-24 88 800 ng•h/ml) bio je nešto viši u odnosu na bolesnike koji nisu Azijci (AUC0-24 77 200 ng•h/ml).
English: %CV SD = Standard Deviation; CV = Coefficient of Variation
Croatian: Srednja vrijednost (SD) Geometrijska srednja vrijednost % CV SD = standardna devijacija; CV = koeficijent varijacije
English: • acute kidney injury, reduced kidney function
Croatian: • akutno oštećenje bubrega, smanjena funkcija bubrega
English: Do not use this medicine after the expiry date which is stated on the label and carton after EXP.
Croatian: Ovaj se lijek ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici i kutiji.
English: Live attenuated influenza vaccines should not be given until 48 hours after treatment with Alpivab.
Croatian: Živa atenuirana cjepiva protiv gripe ne smiju se davati u razdoblju od 48 sati nakon liječenja lijekom Alpivab.
English: • Visually inspect the peramivir concentrate 10 mg/mL.
Croatian: • Vizualno provjerite koncentrat peramivira od 10 mg/ml.
English: Elderly No dose adjustment is required based on age (see sections 4.4 and 5.2).
Croatian: Nije potrebna prilagodba doze na osnovi dobi (vidjeti dijelove 4.4 i 5.2).
English: The primary endpoint, time to alleviation of symptoms, was defined as the number of hours from initiation of study drug until the start of the 24 hour period in which all seven symptoms of influenza (cough, sore throat, nasal congestion, headache, feverishness, myalgia and fatigue) were either absent or present at a level no greater than mild for at least 21.5 hours.
Croatian: Primarna mjera ishoda, vrijeme potrebno za ublažavanje simptoma, definirana je kao broj sati od početka primjene ispitivanog lijeka do početka 24-satnog razdoblja u kojem je svih sedam simptoma gripe (kašalj, grlobolja, začepljenost nosa, glavobolja, grozničavost, mialgija i umor) izostalo ili bilo prisutno na razini ne većoj od blage najmanje 21,5 sati.
English: Table 2: Peramivir dose for adults and adolescents (from 13 years and 50 kg) based on absolute GFR Absolute Glomerular Filtration Rate (GFR)*
Croatian: Tablica 2: Doza peramivira za odrasle i adolescente (s ≥13 godina i ≥50 kg) na temelju apsolutnog GFR-a Apsolutna brzina glomerularne filtracije (GFR)*
English: Live attenuated influenza vaccines are not recommended to be used until 48 hours following Alpivab administration due to a theoretical risk that peramivir could reduce the immunogenicity of the vaccine.
Croatian: Ne preporučuje se primjena živih atenuiranih cjepiva protiv gripe prije isteka 48 sati nakon davanja lijeka Alpivab zbog teoretskog rizika da bi peramivir mogao smanjiti imunogenost cjepiva.
English: There is no preservative or antibacterial agent in the solution.
Croatian: U otopini nema konzervansa ni antibakterijskih tvari.
English: Pharmacokinetics of peramivir in subjects 2 to 17 years of age (administered 12 mg/kg or 600 mg according to age and body weight) and in healthy adults (administered 600 mg) was similar (Table 5).
Croatian: Farmakokinetika peramivira u ispitanika u dobi od 2 do 17 godina (koji su primili 12 mg/kg ili 600 mg u skladu s dobi i tjelesnom težinom) i u zdravih odraslih ispitanika (koji su primili 600 mg) bila je slična (tablica 5).
English: Resistance
Croatian: Otpornost
English: The pharmacokinetics of peramivir was evaluated in 20 elderly subjects (>65 years of age) following a single 4 mg/kg IV dose of peramivir.
Croatian: Farmakokinetika peramivira ocijenjena je na 20 starijih bolesnika (>65 godina) nakon jednokratne intravenske doze peramivira od 4 mg/kg.
English: No human data on the effect of peramivir on fertility are available.
Croatian: Nisu dostupni podaci o učincima peramivira na plodnost u ljudi.
English: The pharmacokinetics of peramivir has been evaluated in a study in paediatric subjects 2 to 17 years of age with uncomplicated influenza.
Croatian: Farmakokinetika peramivira ocijenjena je u ispitivanju na pedijatrijskim ispitanicima u dobi od 2 do 17 godina oboljelima od nekomplicirane gripe.
English: Pack size of 3 single-use vials.
Croatian: Pakiranje od 3 bočice za jednokratnu uporabu.
English: Available pharmacodynamic/toxicological data in animals have shown excretion of peramivir in milk (see section 5.3).
Croatian: Dostupni farmakodinamički/toksikološki podaci pokazali su da se u životinja peramivir izlučuje u mlijeko (vidjeti dio 5.3).
English: In clinical trials, H275Y was the only resistance-associated treatment-emergent mutation in the neuraminidase gene that occurred in virus obtained from more than one peramivir-treated subject (in 9 of 481[1.9 %] infected with the A/H1N1 influenza virus).
Croatian: U kliničkim je ispitivanjima mutacija H275Y bila jedina mutacija nastala tijekom liječenja povezana s otpornošću u genu neuraminidaze koja se pojavila u virusu dobivenom od više od jednog ispitanika liječenog peramivirom (u 9 od 481 [1,9 %] zaraženih virusom gripe tipa A/H1N1).
English: No clinically relevant alterations to peramivir pharmacokinetics are expected in patients with hepatic impairment based on the route of peramivir elimination.
Croatian: Ne očekuju se klinički bitne promjene u farmakokinetici peramivira u bolesnika s oštećenjem jetre na temelju načina eliminacije peramivira.
English: The pharmacokinetics of peramivir following a 600 mg intramuscular (IM) injection was similar in males and females with AUC0-∞ of 76,600 ng•hr/mL and 101,000 ng•hr/mL, respectively, and Cmax of 27,760 ng/mL and 34,710 ng/mL, respectively.
Croatian: Farmakokinetika peramivira nakon intramuskularne (i.m.) injekcije od 600 mg bila je slična u muškaraca i žena s AUC0-∞ od 76 600 ng•hr/ml i 101 000 ng•hr/ml te Cmax od 27 760 ng/ml i 34 710 ng/ml.
English: Uncommon, may affect up to 1 in 100 people
Croatian: Manje često, mogu se pojaviti u do 1 na 100 osoba
English: • Add the measured volume of peramivir concentrate into the infusion container.
Croatian: • Izmjerenu količinu koncentrata peramivira dodajte u spremnik infuzije.
English: Unknown
Croatian: Rijetko Nepoznato
English: Psychiatric disorders insomnia abnormal behaviour*, delirium*
Croatian: Psihijatrijski poremećaji nesanica neuobičajeno ponašanje*, delirij*
English: The ITTI population included 84 subjects with influenza confirmed by PCR.
Croatian: Populacija ITTI obuhvaćala je 84 ispitanika oboljela od gripe potvrđene lančanom reakcijom polimeraze.
English: Common adverse reactions not reported in adults were injection site rash, pyrexia, tympanic membrane hyperaemia, psychomotor hyperactivity, and pruritus.
Croatian: Česte nuspojave koje nisu zabilježene u odraslih bile su osip na mjestu injiciranja, pireksija, hiperemija timpanske membrane, psihomotorna hiperaktivnost i pruritus.
English: The elderly subjects enrolled were aged 65 to 79 years, with a mean age of 70.1 years, with creatinine clearance (Cockcroft-Gault calculation) CrClcg ranging from 82.8 mL/min to 197.9 mL/min.
Croatian: Stariji ispitanici obuhvaćeni ispitivanjem bili su u dobi od 65 do 79 godina, srednje vrijednosti dobi od 70,1 godina, s vrijednosti klirensa kreatinina (CockcroftGaultova formula) CrClcg u rasponu od 82,8 ml/min do 197,9 ml/min.
English: Symptoms may include skin or throat swelling, difficulty breathing, blistering rash or peeling skin.
Croatian: Simptomi mogu uključivati oticanje kože ili grla, otežano disanje, osip u obliku mjehurića ili ljuštenje kože.
English: There is no experience of acute overdose with peramivir in humans.
Croatian: Nema iskustava akutnog predoziranja peramivirom u ljudi.
English: Following intravenous administration of a single dose of peramivir 600 mg over 30 minutes, Cmax was reached at the end of infusion.
Croatian: Nakon intravenske primjene jednokratne doze 600 mg peramivira tijekom 30 minuta, vrijednost Cmax dosegnuta je na kraju infuzije.
English: This medicine contains 212.4 mg sodium (main component of cooking/table salt) in each dose consisting of 3 vials.
Croatian: Ovaj lijek sadrži 212,4 mg natrija (glavni sastojak kuhinjske soli) u pojedinačnoj dozi koja se sastoji od triju bočica.
English: A randomised, multicentre, double-blind trial conducted in Japan evaluated a single intravenous administration of peramivir 300 mg or 600 mg, or placebo administered over 30 minutes in subjects 20 to 64 years of age with uncomplicated influenza.
Croatian: Randomiziranim, multicentričnim, dvostruko slijepim ispitivanjem provedenim u Japanu ocjenjivala se jednokratna intravenska primjena peramivira od 300 mg ili 600 mg ili placeba, s trajanjem primjene od 30 minuta u ispitanika u dobi od 20 do 64 godine s nekompliciranom gripom.