FrancophonIA/ELRC3.0 huggingface dataset:
English: This interaction may be due to modification of P-glycoprotein mediated digoxin efflux by ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer.
Slovenian: Interakcija je morda posledica tega, da ritonavir, odmerjan kot protiretrovirusno zdravilo ali farmakokinetični stopnjevalec, spremeni s P-glikoproteinom posredovani iztok digoksina.
English: Adverse reactions of nausea, dizziness, hypotension and syncope have been observed in single dose interaction studies in healthy volunteers (see section 4.5).
Slovenian: V študijah medsebojnega delovanja z enim odmerkom pri zdravih prostovoljcih so zabeležili neželene učinke: navzeo, omotico, hipotenzijo in sinkopo (glejte poglavje 4.5).
English: Thyroid hormone replacement therapy
Slovenian: Nadomestno zdravljenje s ščitničnimi hormoni
English: For specific information regarding the impact of co-administration of acid reducing agents, refer to the Summary of Product Characteristics of the co-administered protease inhibitor.
Slovenian: Za specifične informacije o vplivu sočasne uporabe zdravil, ki zmanjšujejo kislino, glejte povzetek glavnih značilnosti hkrati uporabljanega zaviralca proteaz.
English: Darunavir 800 mg once daily with ritonavir 100 mg once daily in ART-naïve patients.
Slovenian: Darunavir 800 mg enkrat na dan z ritonavirjem 100 mg enkrat na dan pri bolnikih, ki še niso dobivali ART
English: Careful monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with antiretroviral doses of ritonavir (see section 4.4).
Slovenian: Med sočasno uporabo teh zdravil in protiretrovirusnih odmerkov ritonavirja je priporočljivo natančno nadziranje terapevtskih in neželenih učinkov (glejte poglavje 4.4).
English: Ritonavir is considered high in sodium.
Slovenian: Ritonavir ima veliko vsebnost natrija.
English: Thereby, increasing the risk of serious arrhythmias from these agents.
Slovenian: S tem se poveča tveganje za resne aritmije, povzročene s tema zdraviloma.
English: 0.5 single IV dose
Slovenian: 0,5, posamičen i.v.
English: Darunavir must be given with ritonavir to ensure its therapeutic effect.
Slovenian: Za zagotovitev terapevtskega učinka darunavirja je treba darunavir uporabljati skupaj z ritonavirjem.
English: Lopinavir co-formulated with ritonavir (lopinavir/ritonavir) 400 mg/100 mg or 800 mg/200 mg. Saquinavir 1,000 mg twice daily with ritonavir 100 mg twice daily in ART experienced patients.
Slovenian: Amprenavir 600 mg dvakrat na dan z ritonavirjem 100 mg dvakrat na dan Atazanavir 300 mg enkrat na dan z ritonavirjem 100 mg enkrat na dan Fosamprenavir 700 mg dvakrat na dan z ritonavirjem 100 mg dvakrat na dan Lopinavir v kombinaciji z ritonavirjem (lopinavir/ritonavir) 400 mg/100 mg ali 800 mg/200 mg Sakvinavir 1000 mg dvakrat na dan z ritonavirjem 100 mg dvakrat na dan pri bolnikih, ki so bili predhodno zdravljeni z antiretrovirusno terapijo (ART).
English: 500 q12 h ↓ 62% ↓ 59%
Slovenian: 500 na 12 ur ↓ 62 %
English: 500 q12 h ↓ 40% ↓ 32%
Slovenian: 500 na 12 ur ↓ 40 %
English: 20, single dose 200q12h ↑ 124% ↔ The concomitant use of tadalafil for the treatment of erectile dysfunction with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer should be with caution at reduced doses of no more than 10 mg tadalafil every 72 hours with increased monitoring for adverse reactions (see section 4.4).
Slovenian: Med sočasno uporabo tadalafila za zdravljenje erektilne disfunkcije in ritonavirja, odmerjanega kot protiretrovirusno zdravilo ali farmakokinetični stopnjevalec, je potrebna previdnost; odmerek tadalafila je treba zmanjšati in ne sme preseči 10 mg na 72 ur.
English: Ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer
Slovenian: Ritonavir, odmerjan kot protiretrovirusno zdravilo ali farmakokinetični stopnjevalec
English: Myocardial infarction
Slovenian: Bolezni srca občasni miokardni infarkt
English: However, since the renal clearance of ritonavir is negligible, no changes in the total body clearance are expected in patients with renal impairment.
Slovenian: A ker je ledvični očistek ritonavirja zanemarljiv, pri bolnikih z okvaro ledvic ni pričakovati sprememb celotnega telesnega očistka.
English: For further information, refer to the Summary of Product Characteristics for darunavir.
Slovenian: Za dodatne informacije glejte povzetek glavnih značilnosti zdravila za darunavir.
English: Increased plasma concentrations of clozapine and pimozide.
Slovenian: Klozapin, pimozid Zvišana koncentracija klozapina in pimozida v plazmi.
English: Hormonal contraceptive Ethinylestradiol
Slovenian: Hormonski kontraceptivi
English: Concomitant use of vardenafil with ritonavir is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba vardenafila z ritonavirjem je kontraindicirana (glejte poglavje 4.3).
English: Increased plasma concentrations of fusidic acid and ritonavir.
Slovenian: Zvišana koncentracija fusidne kisline in ritonavirja v plazmi
English: Ritonavir doses higher than 100 mg twice daily have not been studied with darunavir.
Slovenian: Odmerki ritonavirja, večji od 100 mg dvakrat na dan skupaj z darunavirjem niso raziskani.
English: Clorazepate, diazepam, estazolam, flurazepam, oral midazolam and triazolam
Slovenian: Klorazepat, diazepam, estazolam, flurazepam, peroralni in parenteralni midazolam in
English: Increased plasma concentrations of clorazepate, diazepam, estazolam, flurazepam, oral midazolam and triazolam.
Slovenian: Zvišana koncentracija klorazepata, diazepama, estazolama, flurazepama, peroralnega midazolama in triazolama v plazmi.
English: Abnormal liver function tests, hepatitis (inflammation of the liver), and rarely jaundice, have been reported in patients taking ritonavir.
Slovenian: Pri bolnikih, ki so jemali ritonavir, so bili opisani nenormalni izvidi testov delovanja jeter, hepatitis (vnetje jeter) in, redko, zlatenica.
English: Pharmacokinetic enhancement by ritonavir is based on ritonavir's activity as a potent inhibitor of CYP3A- mediated metabolism.
Slovenian: Farmakokinetično stopnjevanje z ritonavirjem temelji na tem, da ritonavir močno zavira presnovo s CYP3A.
English: ↑ 2.5 fold ↔
Slovenian: ↑2,5-krat
English: Alpha1-Adrenoreceptor antagonist Alfuzosin
Slovenian: Antagonist adrenergičnih receptorjev α1
English: 200 mg once daily
Slovenian: 200 mg enkrat na dan
English: Hepatic transaminase elevations exceeding five times the upper limit or normal, clinical hepatitis, and jaundice have occurred in patients receiving ritonavir alone or in combination with other antiretrovirals.
Slovenian: Pri bolnikih, ki so prejemali ritonavir sam ali v kombinaciji z drugimi protiretrovirusnimi zdravili, so se pojavljali zvišanje jetrnih transaminaz, ki so presegle petkratno zgornjo normalno mejo, klinični hepatitis in ikterus.
English: β2-agonist (long acting) Salmeterol
Slovenian: Agonisti β2-receptorjev (dolgodelujoči)
English: 400q12h ↓ 82% ↓ 66%
Slovenian: 400 na 12 ur ↓ 82%
English: Ritonavir dosed as an antiretroviral agent is likely to inhibit CYP2D6 and as a result is expected to increase concentrations of haloperidol, risperidone and thioridazine.
Slovenian: Ritonavir, odmerjan kot protiretrovirusno zdravilo, verjetno zavira CYP2D6, zato je treba pričakovati, da zviša koncentracijo haloperidola, risperidona in tioridazina.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent induces glucuronidation and as a result is expected to decrease the plasma concentrations of atovaquone.
Slovenian: Ritonavir, odmerjan kot farmakokinetični stopnjevalec ali kot protiretrovirusno zdravilo, inducira glukuronidacijo, zato je treba pričakovati, da zniža koncentracijo atovakona v plazmi.
English: When used with ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent, the lowest doses of atorvastatin or rosuvastatin should be administered.
Slovenian: Če sta atorvastatin ali rosuvastatin uporabljena hkrati z ritonavirjem kot farmakokinetičnim stopnjevalcem ali protiretrovirusnim zdravilom, je treba uporabiti najmanjše odmerke atorvastatina ali rosuvastatina.
English: Hyperplasia of the retinal pigment epithelium (RPE) and retinal degeneration have been seen in all of the rodent studies conducted with ritonavir, but have not been seen in dogs.
Slovenian: V vseh študijah ritonavirja pri glodalcih so ugotavljali hiperplazijo mrežničnega pigmentnega epitelija in mrežnično degeneracijo; pri psih teh sprememb niso ugotovili.
English: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthroses, in haemophiliac patients type A and B treated with protease inhibitors.
Slovenian: Pri nekaterih bolnikih s hemofilijo tipa A in B so med uporabo zaviralcev proteaz ugotavljali večjo nagnjenost h krvavitvam, vključno s spontanimi kožnimi hematomi in hemartrozami.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent
Slovenian: Ritonavir, odmerjan kot farmakokinetični stopnjevalec ali kot protiretrovirusno zdravilo
English: Increased plasma concentrations of neratinib which may increase the potential for serious and/or life-threatening reactions including hepatotoxicity (see section 4.5).
Slovenian: Zvišana koncentracija neratiniba v plazmi, ki lahko poveča tveganje za resne in/ali življenje ogrožajoče reakcije, vključno s hepatotoksičnostjo (glejte poglavje 4.5).
English: 100, single oral dose
Slovenian: 100, posamičen peroralni odmerek
English: NAME OF THE MEDICINAL PRODUCT Ritonavir Mylan 100 mg film-coated tablets ritonavir
Slovenian: IME ZDRAVILA Ritnovair Mylan 100 mg filmsko obložene tablete ritonavir
English: It is not recommended to co-administer ritonavir with simeprevir.
Slovenian: Sočasna uporaba ritonavirja s simeprevirjem ni priporočljiva.
English: Careful monitoring of therapeutic and adverse effects is recommended when erythromycin or itraconazole is used concomitantly administered with ritonavir.
Slovenian: Med sočasno uporabo eritromicina ali itrakonazola z ritonavirjem je priporočljivo natančno nadziranje terapevtskih in neželenih učinkov.
English: Ritonavir is not recommended in children below 2 years of age due to lack of data on safety and efficacy.
Slovenian: Zaradi pomanjkanja podatkov o varnosti in učinkovitosti ritonavir ni priporočljiv za otroke, mlajše od 2 let.
English: Thereby, increasing the risk of serious haematologic abnormalities, or other serious adverse effects from these agents.
Slovenian: S tem se poveča tveganje za resne hematološke nepravilnosti oz. druge resne neželene učinke teh zdravil.
English: You may also notice irregular uterine bleeding if you are taking this type of hormonal contraceptive with ritonavir.
Slovenian: Če sočasno z ritonavirjem jemljete takšne hormonske kontraceptive, boste morda opazili tudi neredne maternične krvavitve.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING BOTTLE LABEL
Slovenian: PODATKI NA PRIMARNI OVOJNINI OZNAKA NA STEKLENICI 1.
English: Elevated norpethidine concentrations may increase the risk of CNS effects (e.g., seizures), see section 4.3.
Slovenian: Zvišana koncentracija norpetidina lahko poveča tveganje za učinke na osrednjem živčevju (npr. konvulzivne napade), glejte poglavje
English: Increased plasma concentrations of norpethidine, piroxicam and propoxyphene.
Slovenian: Zvišana koncentracija norpetidina, piroksikama in propoksifena v plazmi.
English: 10, single dose 600q12h ↑ 153% ↑ 55% Inhibition of CYP3A and P-gp lead to increased plasma levels and pharmacodynamic effects of rivaroxaban which may lead to an increased bleeding risk.
Slovenian: Zavrtje CYP3A in P-gp poveča koncentracijo rivaroksabana v plazmi in njegove farmakodinamične učinke; to lahko poveča tveganje za krvavitve.
English: Systemic corticosteroid effects including Cushing's syndrome and adrenal suppression (plasma cortisol levels were noted to be decreased 86% in the above study) have been reported in patients receiving ritonavir and inhaled or intranasal fluticasone propionate; similar effects could also occur with other corticosteroids metabolised by CYP3A e.g., budesonide and triamcinolone.
Slovenian: Pri bolnikih, ki so dobivali ritonavir in inhalirani ali intranazalni flutikazonijev propionat, so opisani sistemski učinki kortikosteroidov, vključno s Cushingovim sindromom in adrenalno supresijo (v omenjeni študiji so zabeležili 86 % znižanje koncentracije kortizola v plazmi).
English: Increased plasma concentrations of vardenafil (see sections 4.4. and 4.5).
Slovenian: Zvišana plazemska koncentracija vardenafila (glejte poglavji 4.4 in
English: • if Ritonavir Mylan is used to boost the effects of certain other anti-HIV medicines the typical dose for adults is 1 to 2 tablets once or twice daily.
Slovenian: Priporočeni odmerki zdravila Ritonavir Mylan so: če zdravilo Ritonavir Mylan uporabljate za stopnjevanje učinkov drugih zdravil proti HIV, je odmerek za odrasle praviloma 1 do 2 filmsko obloženi tableti enkrat ali dvakrat na dan. Za podrobna navodila o odmerjanju (vključno z odmerjanjem za otroke) glejte navodila za uporabo drugih zdravil proti HIV, ki jih jemljete v kombinaciji z zdravilom Ritonavir Mylan.
English: 800 q12 h
Slovenian: 800 na 12 ur
English: Iron oxide yellow (E172) Silica, colloidal anhydrous Polysorbate 80
Slovenian: Filmska obloga: hipromeloza titanov dioksid (E171) makrogoli hidroksipropilceluloza smukec rumeni železov oksid (E172) silicijev dioksid, koloidni, brezvodni polisorbat 80
English: What Ritonavir Mylan is and what it is used for Ritonavir Mylan contains the active substance ritonavir.
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Ritonavir Mylan učinkovina je ritonavir.
English: Cmax (μg/ml) Ctrough (μg/ml) 0.08 ± 0.04 0.22
Slovenian: Cmax (μg/ml)
English: ↑ 11 fold
Slovenian: ↑ 11-krat
English: Cardiac and neurologic events have been reported when ritonavir has been co-administered with disopyramide, mexiletine or nefazodone.
Slovenian: Med sočasno uporabo ritonavirja z dizopiramidom, meksiletinom ali nefazodonom so bili opisani kardiološki in nevrološki učinki.
English: 100q12h Darunavir
Slovenian: Darunavir ↑ 14-krat
English: Microsomal triglyceride transfer protein (MTTP) inhibitor
Slovenian: Zdravila za spreminjanje ravni serumskih lipidov Zaviralci reduktaze HMGCoA Zaviralci mikrosomskega transportnega proteina trigliceridov (MTTP)
English: Abemaciclib
Slovenian: Abemaciklib
English: Renal disease
Slovenian: Bolezni ledvic
English: For further information, physicians should refer to the Summary of Product Characteristics for atazanavir.
Slovenian: Za nadaljne informacije glejte povzetek glavnih značilnosti zdravila za atazanavir.
English: HCV protease inhibitor Simeprevir
Slovenian: Zaviralci proteaz virusa hepatitisa C
English: Fosamprenavir must be given with ritonavir to ensure its therapeutic effect.
Slovenian: Za zagotovitev terapevtskega učinka je treba fosamprenavir uporabiti z ritonavirjem.
English: 500 q12 h
Slovenian: 500 na 12 ur
English: ↑ 3-7 fold
Slovenian: ↑ 4.7-krat
English: Caution is warranted during the first several days when alprazolam is co-administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer, before induction of alprazolam metabolism develops.
Slovenian: Kadar je alprazolam uporabljan sočasno z ritonavirjem, odmerjanim kot protiretrovirusno zdravilo ali farmakokinetični stopnjevalec, je prvih nekaj dni potrebna previdnost, preden se razvije indukcija presnove alprazolama.
English: Increased plasma concentrations of sildenafil.
Slovenian: Zvišana koncentracija sildenafila v plazmi.
English: Ritonavir Mylan contains sodium
Slovenian: Zdravilo Ritonavir Mylan vsebuje natrij
English: Due to the large increase in rifabutin AUC, the concomitant use of rifabutin with ritonavir dosed as an antiretroviral agent is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba rifabutina in ritonavirja, odmerjanega kot protiretrovirusno zdravilo, je kontraindicirana zaradi velikega povečanja AUC rifabutina (glejte poglavje 4.3).
English: However, since the renal clearance of ritonavir is negligible, the decrease in the total body clearance is not expected in patients with renal impairment.
Slovenian: A ker je ledvični očistek ritonavirja zanemarljiv, pri bolnikih z okvaro ledvic ni pričakovati zmanjšanja celotnega telesnega očistka.
English: Due to the large therapeutic window of clarithromycin no dose reduction should be necessary in patients with normal renal function.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic odmerka ni treba zmanjševati, ker ima klaritromicin široko terapevtsko okno.
English: When ritonavir is used in combination with another protease inhibitor and buprenorphine, the SPC of the co-administered protease inhibitor should be reviewed for specific dosing information.
Slovenian: Če ritonavir uporabljate v kombinaciji z drugim zaviralcem proteaz in buprenorfinom, morate za specifične informacije o odmerjanju sočasno uporabljenega zaviralca proteaz upoštevati njegov povzetek glavnih značilnosti zdravila (SmPC).
English: When ritonavir is used as a pharmacokinetic enhancer with other PIs, full details on the warnings and precautions relevant to that particular PI should be considered, therefore the Summary of Product Characteristics for the particular PI must be consulted.
Slovenian: Če je ritonavir uporabljen kot farmakokinetični stopnjevalec z drugimi zaviralci proteaz, je treba upoštevati vse podrobnosti opozoril in previdnostnih ukrepov za posamezen zaviralec proteaz; zato natančno preberite povzetek glavnih značilnosti uporabljenega zaviralca proteaz.
English: Ritonavir co-administration is likely to result in increased plasma concentrations of clorazepate, diazepam, estazolam and flurazepam and is therefore contraindicated (see section 4.3).
Slovenian: Sočasna uporaba ritonavirja ponavadi zviša koncentracijo klorazepata, diazepama, estazolama in flurazepama v plazmi in je zato kontraindicirana (glejte poglavje 4.3).
English: Particular caution should be used when prescribing ritonavir in patients taking digoxin since co-administration of ritonavir with digoxin is expected to increase digoxin levels.
Slovenian: Posebna previdnost je potrebna pri predpisovanju ritonavirja bolnikom, ki jemljejo digoksin.
English: Careful monitoring of therapeutic and adverse effects (including respiratory depression) is recommended when fentanyl is concomitantly administered with ritonavir.
Slovenian: Med sočasno uporabo fentanila in ritonavirja je priporočljivo natančno nadziranje terapevtskih in neželenih učinkov (vključno z respiratorno depresijo).
English: Serum concentrations may be increased when co-administered with ritonavir resulting in the potential for increased incidence of adverse reactions.
Slovenian: Sočasna uporaba z ritonavirjem lahko poveča koncentracijo v serumu in posledično tudi pojavljanje neželenih učinkov.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of cyclosporine, tacrolimus or everolimus.
Slovenian: Ritonavir, odmerjan kot farmakokinetični stopnjevalec ali kot protiretrovirusno zdravilo, zavira CYP3A4, zato je treba pričakovati, da zviša koncentracijo ciklosporina, takrolimusa ali everolimusa v plazmi.
English: Cmax recommended when these medicines are concomitantly administered with ritonavir.
Slovenian: Vpliv na Cmax sočasno uporabljenega zdravila farmakokinetičnim stopnjevalcem.
English: For further information, refer to the Summary of Product Characteristics for maraviroc.
Slovenian: Za dodatne informacije glejte povzetek glavnih značilnosti zdravila za maravirok.
English: Due to CYP3A inhibition by ritonavir, concentrations of lurasidone are expected to increase.
Slovenian: Zaradi zavrtja CYP3A z ritonavirjem se pričakuje povečanje koncentracij lurasidona.
English: The co-administration of riociguat with ritonavir is not recommended (see section 4.4 and refer to riociguat SmPC).
Slovenian: Sočasna uporaba riociguata z ritonavirjem ni priporočljiva (glejte poglavje 4.4 in glejte povzetek glavnih značilnosti zdravila za riociguat).
English: ↑ 17-fold ↔ ND
Slovenian: Sakvinavir4 ↑ 17-krat
English: Ritonavir steady-state pharmacokinetic parameters were evaluated in HIV infected children above 2 years of age receiving doses ranging from 250 mg/m2 twice daily to 400 mg/m2 twice daily.
Slovenian: Farmakokinetične parametre ritonavirja v stanju dinamičnega ravnovesja so ocenili pri otrocih, okuženih s HIV, starejših od 2 let, ki so dobivali odmerke od 250 mg/m2 dvakrat na dan do 400 mg/m2 dvakrat na dan. Koncentracije ritonavirja, dosežene po 350 do 400 mg/m2 dvakrat na dan, so bile pri otrocih primerljive tistim pri odraslih po odmerku 600 mg (približno 330 mg/m2) dvakrat na dan.
English: Ritonavir levels may increase on stopping St John's wort.
Slovenian: Koncentracija ritonavirja se lahko po prenehanju jemanja šentjanževke zveča.
English: The concomitant administration with ranolazine is contraindicated (see section 4.3).
Slovenian: Sočasna uporaba z ranolazinom je kontraindicirana (glejte poglavje 4.3).
English: morphine and morphine-like medicines used to treat severe pain (e.g. methadone, fentanyl); sleeping pills (e.g. alprazolam, zolpidem) and also midazolam administered by injection; tranquillisers (e.g. haloperidol, risperidone, thioridazine); colchicine, a treatment for gout.
Slovenian: zdravila za srce (npr. dizopiramid, meksiletin in antagonisti kalcijevih kanalčkov, npr. amlodipin, diltiazem in nifedipin); zdravila z delovanjem na imunski sistem (npr. ciklosporin, takrolimus, everolimus); levotiroksin (za zdravljenje težav s ščitnico); morfin in morfinu podobna zdravila za zdravljenje hudih bolečin (npr. metadon, fentanil); uspavala (npr. alprazolam, zolpidem) in tudi midazolam, ki se daje z injekcijo; pomirjevala (npr. haloperidol, risperidon, tioridazin); kolhicin, zdravilo za zdravljenje protina.
English: Due to reductions in ethinylestradiol concentrations, barrier or other non-hormonal methods of contraception should be considered with concomitant ritonavir use when dosed as an antiretroviral agent or as a pharmacokinetic enhancer.
Slovenian: Med sočasno uporabo ritonavirja, odmerjanega kot protiretrovirusno zdravilo ali farmakokinetični stopnjevalec, je treba zaradi znižanja koncentracije etinilestradiola uporabljati pregradne ali druge nehormonske načine kontracepcije.
English: Divalproex, lamotrigine, phenytoin Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent induces oxidation by CYP2C9 and glucuronidation and as a result is expected to decrease the plasma concentrations of anticonvulsants.
Slovenian: Ritonavir, odmerjan kot farmakokinetični stopnjevalec ali kot protiretrovirusno zdravilo, inducira oksidacijo s CYP2C9 in glukuronidacijo, zato je treba pričakovati, da zniža koncentracijo antiepileptičnih zdravil v plazmi.
English: For further information, physicians should refer to the Summary of Product Characteristics for tipranavir.
Slovenian: Za dodatne informacije glejte povzetek glavnih značilnosti zdravila za tipranavir.
English: Herbal preparations containing St John's wort must not be used in combination with ritonavir.
Slovenian: Zdravil rastlinskega izvora s šentjanževko se zato ne sme uporabljati v kombinaciji z ritonavirjem.
English: • coldness in the hands and feet
Slovenian: - mravljinčenje ali omrtvelost v rokah,
English: In patients who are already taking digoxin when ritonavir is introduced, the digoxin dose should be reduced to one-half of the patients' normal dose and patients need to be followed more closely than usual for several weeks after initiating co-administration of ritonavir and digoxin.
Slovenian: Po začetku sočasne uporabe ritonavirja in digoksina je treba bolnike več tednov kontrolirati pogosteje kot ponavadi.
English: Due to CYP3A inhibition by ritonavir, concentrations of ranolazine are expected to increase.
Slovenian: Zaradi zavrtja CYP3A z ritonavirjem se pričakuje povečanje koncentracij ranolazina.
English: 600 q12 h
Slovenian: 600 na 12 ur