FrancophonIA/ELRC3.0 huggingface dataset:
English: This veterinary medicinal product should only be used in severe cases of periodontal disease.
Slovenian: To zdravilo za uporabo v veterinarski medicini se lahko uporablja le v hudih primerih parodontalne bolezni.
English: Reading RG2 6AD-UK Tel: +44 (0)118 206 3000
Slovenian: RG2 6AD-UK Tel: +44 (0)118 206 3000
English: People with known hypersensitivity to quinolones should avoid any contact with the veterinary medicinal product.
Slovenian: Osebe z znano preobčutljivostjo na kinolone naj se izogibajo stiku z zdravilom.
English: In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Slovenian: Zaradi pomanjkanja raziskav o kompatibilnosti, se to zdravilo za uporabo v veterinarski medicini ne sme mešati z ostalimi zdravili za uporabo v veterinarski medicini.
English: Lactose monohydrate Cellulose, microcrystalline Povidone
Slovenian: Monohidrat laktoze Mikrokristalinična celuloza Povidon
English: No specific antidotes for pradofloxacin (or other fluoroquinolones) are known, therefore, in case of overdose, symptomatic treatment should be given.
Slovenian: Specifični antidoti za pradofloksacin (ali ostale fluorkinolone) niso znani, zato je pri prevelikem odmerjanju zdravljenje simptomatično.
English: Antibacterial Spectrum
Slovenian: Spekter protimikrobnega delovanja
English: Draw out the equivalent dosage into the syringe.
Slovenian: Z brizgo izvlecite ustrezen odmerek.
English: After oral administration of the therapeutic dose to dogs, pradofloxacin is rapidly (Tmax of 2 hours) and almost completely (approximately 100%) absorbed reaching peak concentrations of 1.6 mg/l.
Slovenian: Po peroralnem dajanju terapevtskega odmerka psom, se pradofloksacin absorbira hitro (Tmax 2 uri) in skoraj popolnoma (približno 100%) potem, ko doseže najvišjo koncentracijo 1,6 mg/l.
English: Do not eat, drink or smoke while handling the veterinary medicinal product.
Slovenian: Pri ravnanju z zdravilom ne jejte, pijte ali kadite.
English: Due to the graduation of the syringe the resulting dose range is 5 to 7.5 mg/kg bodyweight according to the following table:
Slovenian: Zaradi gradacije odmerne brizge je odmerjanje med 5 in 7,5 mg/kg telesne mase, v skladu s tabelo:
English: Thus, one syringe should only be used for one animal.
Slovenian: Eno brizgo tako uporabimo za eno žival.
English: Resistance to fluoroquinolones has been reported to arise from five sources, (i) point mutations in the genes encoding for DNA gyrase and/or topoisomerase IV leading to alterations of the respective enzyme, (ii) alterations of drug permeability in Gram-negative bacteria, (iii) efflux mechanisms, (iv)plasmid mediated resistance and (v) gyrase protecting proteins.
Slovenian: Na razvoj odpornosti proti fluorokinolonom vpliva pet vzrokov: (i) točkovna mutacija v genih za kodiranje encima DNK giraze in/ali topoizomerazo IV kar vodi k spremembi ustreznega encima, (ii) spremembe, ki so povezane s prepustnostjo gramnegativnih bakterij za zdravilo, (iii) mehanizem efluksa, (iv) mutacija plazmidnega gena in (v) proteini za zaščito DNK giraze.
English: The combined use of fluoroquinolones with digoxin should also be avoided because of potentially increased oral bioavailability of digoxin.
Slovenian: Prav tako pa se je potrebno izogibati hkratni uporabi fluorokinolonov in digoksina, zaradi morebitnega povečanja oralne bio-razpoložljivosti digoksina.
English: Whenever possible, the veterinary medicinal product should only be used based on susceptibility testing.
Slovenian: Kadar je le mogoče, uporabimo zdravilo za uporabo v veterinarski medicini po predhodnem preverjanju občutljivosti.
English: Fertility: Pradofloxacin has been shown to have no effects on fertility in breeding animals.
Slovenian: Plodnost: Pradofloksacin ne vpliva na plodnost pri vzrejnih živalih.
English: Cross-resistance within the fluoroquinolone class of antimicrobials is common.
Slovenian: Pri protimikrobnih zdravilih iz skupine fluorokinolonov je navzkrižna odpornost običajna.
English: A linear relationship between pradofloxacin serum concentrations and the administered dose is observed in dogs within a tested dose range of 1 to 9 mg/kg body weight.
Slovenian: Opaziti je bilo mogoče linearno razmerje med plazemsko koncentracijo pradofloksacina in odmerkom pri psih, ki so dobivali odmerke v testnem območju od 1 - 9 mg/kg telesne mase.
English: Official and local antimicrobial policies should be taken into account when the product is used.
Slovenian: Upoštevati je potrebno uradno in lokalno usmeritev glede uporabe antimikrobnih zdravil.
English: The medication should be administered for as long as advised by your veterinarian.
Slovenian: Zdravilo dajemo tako dolgo kot je predpisal veterinar.
English: Official and local antimicrobial policies should be taken into account when the veterinary medicinal product is used.
Slovenian: Upoštevati je potrebno uradno in lokalno usmeritev glede uporabe antimikrobnih zdravil za uporabo v veterinarski medicini.
English: In laboratory studies the bioavailability of pradofloxacin was reduced in fed dogs and cats compared to fasted animals.
Slovenian: Pri laboratorijskih raziskavah je biološka razpoložljivost pradofloksacina zmanjšana pri nahranjenih psih in mačkah v primerjavi z živalmi, ki so se postile.
English: Infections of the skin: Superficial pyoderma Deep pyoderma Wound infections Acute infections of the urinary tract Severe infections of the gingiva and periodontal tissues
Slovenian: Okužbe kože: površinska piodermija globoka piodermija okužbe ran Akutne urinarne okužbe Resnejše okužbe dlesni in obzobnega tkiva
English: • as adjunctive treatment to mechanical or surgical periodontal therapy in the treatment of severe infections of the gingiva and periodontal tissues caused by susceptible strains of anaerobic organisms, for example Porphyromonas spp.
Slovenian: • kot dopolnilno zdravljenje pri mehaničnem in operativnem parodontalnemu zdravljenju pri zmernih in resnejših okužbah dlesni in parodontalnega tkiva, ki jih povzročajo občutljivi sevi anaerobnih mikroorganizmov, kot so Porphyromonas spp.
English: In laboratory studies the bioavailability of pradofloxacin was reduced in fed cats compared to fasted animals.
Slovenian: Pri laboratorijskih raziskavah je biološka razpoložljivost pradofloksacina zmanjšana pri nahranjenih mačkah v primerjavi z živalmi, ki so se postile.
English: Pradofloxacin has no effects on the developing cartilage of kittens of 6 weeks of age and older.
Slovenian: Pradofloksacin ne vpliva na rast hrustanca pri mačjih mladičih, starih 6 tednov ali več.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reactions) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated-) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Slovenian: Pogostost neželenih učinkov je določena po naslednjem dogovoru: - zelo pogosti (neželeni učinki se pokažejo pri več kot 1 od 10 zdravljenih živali) - pogosti (pri več kot 1, toda manj kot 10 živali od 100 zdravljenih živali) - občasni (pri več kot 1, toda manj kot 10 živali od 1.000 zdravljenih živali) - redki (pri več kot 1, toda manj kot 10 živali od 10.000 zdravljenih živali) - zelo redki (pri manj kot 1 živali od 10.000 zdravljenih živali, vključno s posameznimi primeri).
English: The combination of fluoroquinolones with theophylline could increase the plasma levels of theophylline by altering its metabolism and thus should be avoided.
Slovenian: V primeru kombinacije fluorokinolonov in teofilina pride do povečanja nivoja teofilina v plazmi zaradi njegovega spremenjenega metabolizma v telesu in se ji je zato potrebno izogibati.
English: Further, fluoroquinolones should not be used in combination with non-steroidal anti-inflammatory drugs (NSAIDs) in animals with a history of seizures because of potential pharmacodynamic interactions in the CNS.
Slovenian: Poleg tega se fluorokinoloni ne smejo uporabljati v kombinaciji z nesteroidnimi protivnetnimi zdravili (NSAID) pri živalih z znano zgodovino epileptičnih napadov, ker lahko povzročajo farmakodinamične interakcije v centralnem živčnem sistemu.
English: For the majority of breeds, pradofloxacin-containing veterinary medicinal products must not be used in dogs of less than 12 months of age and in giant breeds less than 18 months.
Slovenian: Večini pasem zdravila, ki vsebuje pradofloksacin, ne dajemo do starosti 12 mesecev, zelo velikim pasmam pa do 18 mesecev starosti.
English: Shelf life after first opening the container: 3 months.
Slovenian: Rok uporabnosti po prvem odpiranju vsebnika : 3 mesece.
English: DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION Oral use.
Slovenian: ODMERKI ZA POSAMEZNE ŽIVALSKE VRSTE TER POT(I) IN NAČIN UPORABE ZDRAVILA
English: Do not use during lactation since there are no data on pradofloxacin in kittens aged less than 6 weeks.
Slovenian: Uporaba ni priporočljiva v obdobju laktacije, ker ni podatkov o rabi pradofloksacina pri mačjih mladičih, mlajših od 6 tednov.
English: Only those dogs for which periodontal treatment goals cannot be achieved by mechanical treatment alone should be treated with this veterinary medicinal product.
Slovenian: Le psom, pri katerih samo mehanični posegi niso dovolj za zdravljenje parodontalne bolezni, dajemo to zdravilo za uporabo v veterinarski medicini.
English: 4.2 Indications for use, specifying the target species Treatment of:
Slovenian: 4.2 Indikacije za uporabo pri ciljnih živalskih vrstah Zdravljenje:
English: STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS Each tablet contains:
Slovenian: NAVEDBA UČINKOVIN(E) IN DRUGE(IH) SESTAVIN Vsaka tableta vsebuje:
English: Dose of Oral suspension to be given (ml)
Slovenian: Peroralna suspenzija Odmerek (ml)
English: Concurrent administration with metal cations such as those contained in antacids or sucralfate made with magnesium hydroxide or aluminium hydroxide, or multivitamins containing iron or zinc, and dairy products containing calcium, has been reported to decrease the bioavailability of fluoroquinolones.
Slovenian: Biološka razpoložljivost fluorokinolonov se bistveno zmanjša pri sočasnem dajanju kovinskih kationov, ki se nahajajo v antacidih ali sukralfatih, ki vsebujejo magnezijev ali aluminijev hidroksid, ali multivitaminskih pripravkov, ki vsebujejo železo ali cink ter mlečnih izdelkov, ki vsebujejo kalcij.
English: Manufacturer responsible for batch release: KVP Pharma +Veterinär Produkte GmbH Projensdorfer Str. 324
Slovenian: Proizvajalec odgovoren za sproščanje serij: KVP Pharma +Veterinär Produkte GmbH Projensdorfer Str. 324
English: Ask your veterinarian for advice if no improvement of the clinical condition is observed within 3 days after starting the treatment.
Slovenian: Vprašajte svojega veterinarja za nasvet, če se klinično stanje ne izboljša v 3 dneh po začetnem zdravljenju.
English: KVP Pharma + Veterinär Produkte GmbH Projensdorfer Strasse 324
Slovenian: KVP Pharma + Veterinär Produkte GmbH Projensdorfer Str. 324
English: Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Slovenian: Fluorokinolone dajemo za zdravljenje kliničnih stanj, ko se stanje ne izboljša ali pa ne pričakujemo izboljšanja pri uporabi druge skupine antimikrobnih zdravil.
English: Laboratory studies in puppies have shown evidence of arthropathy (damage to the cartilage of joints) after systemic administration of fluoroquinolones.
Slovenian: Pri laboratorijskih raziskavah so pri pasjih mladičih opazili artropatije po sistemskem dajanju fluorokinolonov.
English: To ensure a correct dose, bodyweight should be determined as accurately as possible to avoid under dosing.
Slovenian: Za ustrezen odmerek, določite telesno maso kar se da natačno, da ne bi prišlo do prenizkega odmerjanja.
English: Folding cartons containing aluminium blister packs.
Slovenian: Kartonske zloženke z aluminijastimi pretisnimi omoti.
English: After administration, the syringe should be cleaned with tap water and stored in the carton box together with the veterinary medicinal product.
Slovenian: Po dajanju brizgo speremo pod tekočo vodo in spravimo v škatlo skupaj z zdravilom za uporabo v veterinarski medicini.
English: Folding carton containing 15 ml white high density polyethylene (HDPE) bottle with a polyethylene adapter and a child-resistant closure and a 3 ml polypropylene oral dosing syringe (graduation: 0.1 to 2 ml).
Slovenian: Zloženka s 15 ml- belo polietilensko (HDPE) plastenko s polietilenskim nastavkom in z za otroke varno zaporko ter 3 ml- polipropilensko odmerno brizgo (gradacija 0,1 do 2 ml).
English: Approximately 40% of the administered product is excreted unchanged via the kidneys.
Slovenian: V nepresnovljeni obliki se s sečem izloči približno 40 % odmerjenega zdravila.
English: MIC50
Slovenian: Število MIK50
English: Avoid skin and eye contact with the veterinary medicinal product.
Slovenian: Preprečite stik zdravila za uporabo v veterinarski medicini s kožo in z očmi.
English: The major elimination pathway in cats is glucuronidation.
Slovenian: Glavna pot izločanja je glukoronidacija.
English: Severe infections of the gingiva and periodontal tissues
Slovenian: Resnejše okužbe dlesni in obzobnega tkiva
English: QUANTITY OF THE ACTIVE SUBSTANCE(S) Pradofloxacin 25 mg/ml
Slovenian: KOLIČINA UČINKOVIN(E) Pradofloksacin 25 mg/ml
English: PACKAGE SIZE 30 ml bottle
Slovenian: VELIKOST PAKIRANJA 30 ml plastenka
English: - 7 tablets - 21 tablets - 70 tablets - 140 tablets
Slovenian: - 7 tablet - 21 tablet - 70 tablet -140 tablet
English: The high volume of distribution (Vd) >2 l/kg bodyweight indicates good tissue penetration.
Slovenian: Velik volumen razporeditve (Vd) > 2 l/kg telesne mase kaže, da se pradofloksacin dobro razporedi v tkivu.
English: Acute infections of the upper respiratory tract
Slovenian: Akutne okužbe zgornjih dihalnih poti
English: Long-term daily treatment has no impact on the pharmacokinetic profile, with an accumulation index of 1.1.
Slovenian: Dnevno zdravljenje v daljšem časovnem obdobju ne vpliva na famakokinetični profil (akumulacijski faktor 1,1).
English: Major elimination pathways are glucuronidation as well as renal excretion.
Slovenian: Glavni poti izločanja sta glukoronidacija in izločanje preko ledvic.
English: Magnesium stearate Silica, colloidal anhydrous Artificial beef flavour Croscarmellose sodium
Slovenian: Magnezijev stearat Brezvodni koloidni silikagel Umetni okus govedine Premreženi natrijev karmelozat
English: The high volume of distribution (Vd) >4 l/kg body weight indicates good tissue penetration.
Slovenian: Velik volumen razporeditve (Vd) > 4 l/kg telesne mase kaže, da se pradofloksacin dobro razporedi v tkivu.
English: Bodyweight of Cat (kg)
Slovenian: Telesna masa mačke (kg)
English: Wound infections and abscesses Acute infections of the upper respiratory tract
Slovenian: Okužene rane in abscesi Akutne okužbe zgornjih dihalnih poti
English: After oral administration of the veterinary medicinal product to cats at the recommended therapeutic dose, absorption of pradofloxacin is rapid, reaching peak concentrations of 2.1 mg/l within 1 hour.
Slovenian: Pri mačkah absorpcija veterinarskega zdravila po peroralnem dajanju priporočenega terapevtskega odmerka hitro doseže najvišjo koncentracijo 2,1 mg/l v 1 uri.
English: To facilitate accurate dosing, the 15 ml bottle of Veraflox oral suspension is supplied together with a 3 ml oral dosing syringe (graduation: 0.1 to 2 ml).
Slovenian: Za lažje odmerjanje je plastenki zdravila Veraflox dodana 3 ml- odmerna brizga za peroralno dajanje (gradacija : 0,1 do 2 ml)
English: Due to potential harmful effects, the tablets must be kept out of the sight and reach of children.
Slovenian: Zaradi morebitnih škodljivih učinkov, tablete shranjujte nedosegljivo otrokom.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Pradofloxacin 25 mg/ml Preservative: Sorbic acid (E200)
Slovenian: NAVEDBA UČINKOVIN(E) Pradofloksacin 25 mg/ml Konzervans: sorbinska kislina (E200)
English: Due to the lack of data, pradofloxacin should not be used in kittens aged less than 6 weeks.
Slovenian: Zaradi pomanjkanja podatkov pradofloksacina ne dajemo mačjim mladičem, mlajšim od 6 tednov.
English: Pradofloxacin dose (mg/kg bw)
Slovenian: Pradofloksacin Odmerek (mg/kg t m.)
English: In cats, absorption of orally administered pradofloxacin at the therapeutic dose is rapid reaching peak concentrations of 1.2 mg/l within 0.5 hours.
Slovenian: Pri mačkah absorpcija pradofloksacina po peroralnem dajanju hitro doseže najvišjo koncentracijo 1,2 mg/l v 0,5 ure.
English: EU/2/10/107/005 7 tablets EU/2/10/107/006 21 tablets EU/2/10/107/007 70 tablets EU/2/10/107/008 140 tablets
Slovenian: EU/2/10/107/005 7 tablet EU/2/10/107/006 21 tablet EU/2/10/107/007 70 tablet EU/2/10/107/008 140 tablet
English: MIC range (µg/ml)
Slovenian: MIK razpon (µg/ml)
English: EU/2/10/107/009 7 tablets EU/2/10/107/010 21 tablets EU/2/10/107/011 70 tablets EU/2/10/107/012 140 tablets
Slovenian: EU/2/10/107/009 7 tablet EU/2/10/107/010 21 tablet EU/2/10/107/011 70 tablet EU/2/10/107/012 140 tablet
English: Ask your veterinarian for advice if no improvement of the clinical conditions is observed within 3 days after starting the treatment, although for superficial pyoderma this time should be increased to 7 days, and for deep pyoderma to 14 days.
Slovenian: Vprašajte za nasvet svojega veterinarja, če se stanje ne izboljša v 3 dneh, pri površinski piodermiji v 7 dneh in pri globoki piodermiji v 14 dneh po začetnem zdravljenju.
English: Do not use in cats with central nervous system (CNS) disorders, such as epilepsy, as fluoroquinolones could potentially cause seizures in predisposed animals.
Slovenian: Ne uporabite pri mačkah z motnjami centralnega živčnega sistema npr. epilepsijo, ker lahko fluorokinoloni povzročijo njen napad pri predisponiranih živalih.
English: Folding carton containing 30 ml white high density polyethylene (HDPE) bottle with a polyethylene adapter and a child-resistant closure.
Slovenian: Zloženka s 30 ml- belo polietilensko (HDPE) plastenko s polietilenskim nastavkom in z zaotroke varno zaporko.
English: Do not use in dogs during the period of growth as developing articular cartilage may be affected.
Slovenian: Zdravila ne dajemo psom v obdobju rasti, ker lahko vpliva na rast sklepnega hrustanca.
English: Repeated dosing shows no impact on the pharmacokinetic profile, (accumulation index = 1.2).
Slovenian: Ponovno dajanje ne vpliva na farmakokinetični profil (akumulacijski faktor 1,2).
English: Do not use in dogs with central nervous system (CNS) disorders, such as epilepsy, as fluoroquinolones could possibly cause seizures in predisposed animals.
Slovenian: Ne uporabite pri psih z motnjami centralnega živčnega sistema npr. epilepsijo, ker lahko fluorokinoloni povzročijo njen napad pri predisponiranih živalih.
English: In case of gingivitis and periodontitis, Veraflox should only be used as an adjunct to mechanical or surgical periodontal therapy.
Slovenian: Pri zdravljenju gingivitisa in parodontitisa uporabimo to zdravilo samo za podporno zdravljenje po mehaničnem ali operativnem posegu.
English: Pregnancy, lactation and Fertility: The safety of Veraflox has not been established during pregnancy and lactation in cats and dogs.
Slovenian: Brejost, laktacija in plodnost: Varnost zdravila v obdobju brejosti in laktacije pri psih in mačkah ni bila ugotovljena.
English: EU/2/10/107/001 7 tablets EU/2/10/107/002 21 tablets EU/2/10/107/003 70 tablets EU/2/10/107/004 140 tablets
Slovenian: EU/2/10/107/001 7 tablet EU/2/10/107/002 21 tablet EU/2/10/107/003 70 tablet EU/2/10/107/004 140 tablet
English: Pradofloxacin induced eye malformations at foetal and maternal toxic doses in rats.
Slovenian: Pradofloksacin povzroča očesne okvare pri podganah pri odmerkih, ki imajo fetotoksični učinek ter toksični učinek na mater.
English: Dosages
Slovenian: Odmerki
English: Repeated dosing shows no impact on the pharmacokinetic profile (accumulation index = 1.0).
Slovenian: Ponovno dajanja ne vpliva na farmakokinetični profil (akumulacijski faktor 1,0).
English: Superficial pyoderma Deep pyoderma
Slovenian: površinska piodermija globoka piodermija okužbe ran
English: • wound infections and abscesses caused by susceptible strains of Pasteurella multocida and the
Slovenian: • okuženih ran in abscesov, ki jih povzročajo občutljivi sevi Pasteurelle multocida in skupina
English: PACKAGE LEAFLET: Veraflox 60 mg and 120 mg tablets for dogs
Slovenian: NAVODILO ZA UPORABO Veraflox 60 mg in 120 mg tablete za pse
English: Do not use in cats during pregnancy and lactation (see section “Special Warnings”).
Slovenian: Ne uporabite pri mačkah v obdobju brejosti in laktacije (glej poglavje »Posebna opozorila«).
English: The treatment should be re-considered if no improvement of the clinical conditions is observed within 3 days, or in cases of superficial pyoderma 7 days, and in cases of deep pyoderma 14 days, after starting the treatment.
Slovenian: Če se stanje ne izboljša v 3 dneh, pri površinski piodermiji v 7 dneh in pri globoki piodermiji v 14 dneh, je potrebno o zdravljenju ponovno razmisliti.
English: 7 tablets 21 tablets 70 tablets 140 tablets
Slovenian: 7 tablet 21 tablet 70 tablet 140 tablet
English: Do not use in dogs during pregnancy and lactation (see section “Special Warnings”).
Slovenian: Ne uporabite pri psih v obdobju brejosti in laktacije (glej poglavje »Posebna opozorila«).
English: Reversible association between pradofloxacin and DNA gyrase or DNA topoisomerase IV in the target bacteria results in inhibition of these enzymes and rapid death of the bacterial cell.
Slovenian: Pradofloksacin v bakterijski celici tarčno deluje predvsem na DNK- girazo in topoizomerazo IV, zavira njuno aktivnost in povzroči smrt bakterijske celice.
English: PACKAGE LEAFLET: Veraflox 15 mg tablets for dogs and cats
Slovenian: NAVODILO ZA UPORABO Veraflox 15 mg tablete za pse in mačke
English: Animal Health Drammensveien 288 NO-0283 Oslo Tlf: +47 23130500
Slovenian: Animal Health Drammensveien 147 B NO-0277 Oslo Tlf: +47 24 11 18 00
English: PACKAGE SIZE - 15 ml bottle and a 3ml oral dosing syringe
Slovenian: VELIKOST PAKIRANJA 15 ml plastenka in 3 ml odmerna brizga
English: As for other fluoroquinolones, the renal excretion rate of pradofloxacin may be decreased in dogs with impaired kidney function and, therefore, pradofloxacin should be used with caution in such animals.
Slovenian: Kot pri drugih fluorokinolonih, je lahko pri psih, ki imajo okrnjeno funkcijo ledvic, izločanje pradofloksacina upočasnjeno.
English: Use of the veterinary medicinal product deviating from instructions given in the summary of product characteristics (SPC) may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other fluoroquinolones due to the potential for crossresistance.
Slovenian: Uporaba zdravila za uporabo v veterinarski medicini, ki ni v skladu z navodili, ki so navedeni v Povzetku glavnih značilnosti zdravila, lahko vpliva na povečanje prevalence bakterij, ki so odporne proti fluorokinolonom ter zmanjša učinke zdravljenja z drugimi fluorokinoloni zaradi možne navzkrižne rezistence.
English: Do not use in dogs with persisting articular cartilage lesions, since lesions may worsen during treatment with fluoroquinolones.
Slovenian: Ne uporabite pri psih s trdovratnimi lezijami sklepnega hrustanca, ker se lahko stanje lezij poslabša med zdravljenjem s fluorokinoloni.
English: The primary mode of action of the fluoroquinolones involves interaction with enzymes essential for major DNA functions such as replication, transcription and recombination.
Slovenian: Primarno delovanje flourokinolonov temelji na interakciji z encimi, ki sodelujejo pri podvojevanju, obnovi in prepisu deoksiribonukleinske kisline (DNK) v bakterijski celici.
English: Do not use in dogs during pregnancy and lactation (see section 4.7).
Slovenian: Ne uporabite pri psih v obdobju brejosti in laktacije, glejte poglavje 4.7.