FrancophonIA/ELRC3.0 huggingface dataset:
English: You must not use YERVOY if you are pregnant unless your doctor specifically recommends it.
Croatian: Ne smijete primati YERVOY ako ste trudni, osim ako to liječnik nije izričito preporučio.
English: Age (2-87 years) had no clinically important effect on the CL of ipilimumab.
Croatian: Dob (2-87 godina) nije imala klinički značajnog učinka na klirens ipilimumaba.
English: if you have recently been prescribed Zelboraf (vemurafenib, another medicine for the treatment of skin cancer).
Croatian: ako Vam je nedavno propisan Zelboraf (vemurafenib, još jedan lijek za liječenje raka kože).
English: Adults and adolescents 12 years of age and older
Croatian: Odrasli i adolescenti u dobi od 12 i više godina
English: - inflammation of the nerves that can lead to paralysis.
Croatian: - upala živaca koja može dovesti do paralize.
English: These may be signs of inflammation of the lungs (pneumonitis or interstitial lung disease).
Croatian: To mogu biti znakovi upale pluća (pneumonitisa ili intersticijske bolesti pluća).
English: The majority had received all 4 doses during induction.
Croatian: Većina je primila sve 4 doze tijekom uvodne terapije.
English: Median age was 15 years.
Croatian: Medijan starosti je bio 15 godina.
English: A total of 77 patients had a history of previously treated brain metastases.
Croatian: Ukupno 77 bolesnika imalo je prethodno liječene moždane metastaze.
English: Patients should receive the entire induction regimen (4 doses) as tolerated, regardless of the appearance of new lesions or growth of existing lesions.
Croatian: Bolesnici trebaju primiti cijeli uvodni režim (4 doze) ukoliko ga podnose, bez obzira na pojavu novih lezija ili rast postojećih.
English: In clinical trials, patients received up to 20 mg/kg without apparent toxic effects.
Croatian: U kliničkim su ispitivanjima bolesnici primili do 20 mg/kg bez vidljivih toksičnih učinaka.
English: Very rare (may affect up to 1 in 10,000 people) Serious, potential life-threatening allergic reaction
Croatian: Vrlo rijetko (mogu se javiti u do 1 na 10 000 osoba) Ozbiljne, potencijalno po život opasne alergijske reakcije
English: Additional information about these potentially inflammatory adverse reactions is provided in “Description of selected adverse reactions” and section 4.4.
Croatian: Dodatne informacije o ovim potencijalno upalnim nuspojavama nalaze se u dijelu “Opis odabranih nuspojava” i dijelu 4.4.
English: Please note that these signs and symptoms are sometimes delayed, and may develop weeks or months after your last dose.
Croatian: Obratite pozornost na to da se ovi znakovi i simptomi ponekad mogu pojaviti kasno, čak tjednima ili mjesecima nakon zadnje doze koju ste primili.
English: Animal reproduction studies have shown reproductive toxicity (see section 5.3).
Croatian: Ispitivanja reproduktivne funkcije na životinjama pokazala su reproduktivnu toksičnost (vidjeti dio 5.3).
English: Additional efficacy results are presented in Table 13.
Croatian: Dodatni podaci o djelotvornosti prikazani su u Tablici 13.
English: Table 3C:
Croatian: Tablica 3C:
English: Your doctor may give you other medicines in order to prevent more severe complications and reduce your symptoms, withhold the next dose of YERVOY, or stop your treatment with YERVOY altogether.
Croatian: Liječnik Vam može dati druge lijekove kako bi spriječio teže komplikacije i ublažio Vaše simptome, odgoditi primjenu sljedeće doze lijeka YERVOY ili potpuno obustaviti liječenje lijekom YERVOY.
English: There are no data on the use of ipilimumab in pregnant women.
Croatian: Ne postoje podaci o primjeni ipilimumaba u trudnica.
English: Long-term hormone replacement therapy may be necessary.
Croatian: Može biti potrebna i dugotrajna hormonska nadomjesna terapija.
English: Overall, no apparent association was observed between antibody development and adverse reactions.
Croatian: Općenito, nije primijećena nikakva vidljiva povezanost između razvoja protutijela i nuspojava.
English: Treatment must be initiated and supervised by specialist physicians experienced in the treatment of cancer.
Croatian: Liječenje mora započeti i nadzirati liječnik specijalist s iskustvom u liječenju karcinoma.
English: Bristol-Myers Squibb Company 6000 Thompson Road East Syracuse, New York 13057 United States
Croatian: Bristol-Myers Squibb Company 6000 Thompson Road East Syracuse, New York 13057 Sjedinjene Američke Države
English: At the recommended dose of 3 mg/kg median OS was similar in the subgroup of females ≥ 50 years of age compared to the overall population: (11.40 vs 11.53 months).
Croatian: U preporučenoj dozi od 3 mg/kg medijan OS bio je sličan u podskupini žena ≥ 50 godina u usporedbi s ukupnom populacijom: (11,40 naspram 11,53 mjeseci).
English: You may notice the appearance of new lesions or growth of existing lesions on your skin, which can be expected when you are being treated with YERVOY.
Croatian: Možda ćete primijetiti pojavu novih lezija ili rast postojećih na koži, što se može očekivati dok se liječite lijekom YERVOY.
English: No. at Risk mg/kg 965 429 127 73 41 29 28 12 8 4 0
Croatian: Broj s rizikom mg/kg 965 429 127 73 41 29 28 12 8 4 0
English: Skin:
Croatian: Koža:
English: Neutralising antibodies against ipilimumab ranged from 0 to 0.3%.
Croatian: Neutralizirajuća protutijela na ipilimumab kretala su se u rasponu od 0 do 0,3%.
English: As the subgroups analysis includes only small numbers of patients, no definitive conclusions can be drawn from these data.
Croatian: Kako analiza podskupina uključuje samo mali broj bolesnika, iz ovih se podataka ne mogu izvući konačni zaključci.
English: Significant systemic exposure of the infant is not expected and no effects on the breast-fed newborn/infant are anticipated.
Croatian: Ne očekuje se značajna sistemska izloženost dojenčeta, niti se predviđaju ikakvi učinci na dojeno novorođenče/dojenče.
English: Limited, but no long-term, safety data is available on the use of ipilimumab in adolescents 12 years of age and older.
Croatian: Dostupni su ograničeni, ali ne i dugoročni sigurnosni podaci primjene ipilimumaba u adolescenata u dobi od 12 i više godina.
English: Reported also in studies outside the pooled dataset.
Croatian: Prijavljeno i u ispitivanjima izvan objedinjene skupine podataka.
English: The most common clinical presentation includes headache and fatigue.
Croatian: Najčešća klinička slika uključuje glavobolju i umor.
English: No differences in the spectrum of irARs reported in adults and the paediatric population were evident.
Croatian: Razlike u spektru prijavljenih irAR-ova u odraslih i pedijatrijskoj populaciji nisu bile zamjetne.
English: Tell your doctor immediately if you get any of these side effects.
Croatian: Odmah obavijestite liječnika ako dobijete neku od ovih nuspojava.
English: What YERVOY is and what it is used for
Croatian: Što je YERVOY i za što se koristi
English: The effects of YERVOY in pregnant women are not known, but it is possible that the active substance, ipilimumab, could harm an unborn baby.
Croatian: Učinci lijeka YERVOY u trudnica nisu poznati, ali postoji mogućnost da bi djelatna tvar, ipilimumab, mogla naštetiti nerođenom djetetu.
English: Moderate diarrhoea or colitis that either is not controlled with medical management or that persists (5-7 days) or recurs
Croatian: Umjereni proljev ili kolitis koji se ne kontrolira lijekovima ili koji traje (5-7 dana) ili se ponavlja
English: SN: <NN:>
Croatian: <NN:>
English: More than one vial may be necessary to obtain the required dose.
Croatian: Može biti potrebno više od jedne bočice da se dobije potrebna doza.
English: Evaluation of laboratory results to assess endocrine function may be performed before corticosteroid therapy is initiated.
Croatian: Laboratorijske pretrage za procjenu endokrine funkcije mogu se napraviti prije početka kortikosteroidne terapije.
English: Because of potential adverse reactions such as fatigue (see section 4.8), patients should be advised to use caution when driving or operating machinery until they are certain that ipilimumab does not adversely affect them.
Croatian: Zbog mogućih nuspojava kao što je umor (vidjeti dio 4.8), bolesnicima treba savjetovati oprez pri vožnji ili upravljanju strojevima dok ne budu sigurni da ipilimumab na njih ne djeluje štetno.
English: Combination phase, every 3 weeks for 4 dosing cycles
Croatian: Faza kombinirane terapije, svaka 3 tjedna za 4 ciklusa doziranja
English: Additional treatment with ipilimumab (re-treatment) was offered to those who developed PD after initial clinical response (PR or CR) or after SD (per the modified WHO criteria) > 3 months from the first tumour assessment.
Croatian: Dodatno liječenje ipilimumabom (ponovno liječenje) ponuđeno je onima koji su razvili PD nakon početnog kliničkog odgovora (PR ili CR) ili nakon SD (prema prilagođenim kriterijima SZO) > 3 mjeseca od prve procjene tumora.
English: Early diagnosis and appropriate management are essential to minimise life-threatening complications.
Croatian: Potrebno je rano postaviti dijagnozu i uvesti odgovarajuće liječenje kako bi se minimalizirale životno opasne komplikacije.
English: The maximum tolerated dose of ipilimumab has not been determined.
Croatian: Maksimalna podnošljiva doza ipilimumaba nije utvrđena.
English: CTLA-4 blockade can also reduce T-regulatory cell function, which may contribute to an anti-tumour immune response.
Croatian: Blokada CTLA-4 može također smanjiti funkciju regulacijskih T-stanica što može pridonijeti antitumorskom imunološkom odgovoru.
English: However, because of the potential for adverse reactions in nursing infants, a decision must be made whether to discontinue breast-feeding or to discontinue from YERVOY therapy taking into account the benefit of breast-feeding for the child and the benefit of YERVOY therapy for the woman.
Croatian: Međutim, zbog mogućnosti nuspojava u dojenčadi, potrebno je odlučiti da li prekinuti dojenje ili prekinuti liječenje lijekom YERVOY, uzimajući u obzir korist dojenja za dijete i korist liječenja lijekom YERVOY za ženu.
English: Overall Survival (Months)
Croatian: Ukupno preživljenje (mjeseci)
English: Age ≥ 12 to 21 years
Croatian: Dob ≥12 do 21 godine
English: Table 3A
Croatian: Tablica 3A
English: The adverse reaction mostly responded well to treatment with corticosteroids.
Croatian: Nuspojave uglavnom dobro odgovaraju na liječenje kortikosteroidima.
English: Overall survival (OS) was also evaluated.
Croatian: Također se ocijenjivalo ukupno preživljenje (engl. overall survival OS).
English: Patients should be monitored continuously (at least up to 5 months after the last dose) as an adverse reaction with ipilimumab in combination with nivolumab may occur at any time during or after discontinuation of therapy.
Croatian: Bolesnike je potrebno kontinuirano nadzirati (najmanje 5 mjeseci nakon posljednje doze) jer kod primjene ipilimumaba u kombinaciji s nivolumabom nuspojava može nastupiti u bilo kojem trenutku tijekom ili nakon prekida terapije.
English: In some cases, addition of other immunosuppressive therapy may be considered (see section 4.4).
Croatian: U nekim se slučajevima može razmotriti dodavanje druge imunosupresivne terapije (vidjeti dio 4.4).
English: The median age was 57 years.
Croatian: Medijan dobi iznosio je 57 godina.
English: Skin: Moderate to severe (Grade 3)b skin rash or (Grade 2)
Croatian: Koža: Umjereni do teški (3. stupanj)b kožni osip ili (2. stupanj)
English: For patients with a history of autoimmune disease, see also section 4.4.
Croatian: Za bolesnike s autoimunom bolešću u anamnezi, vidjeti također dio 4.4.
English: Pharmacotherapeutic group: Antineoplastic agents, monoclonal antibodies, ATC code: L01XC11.
Croatian: Farmakoterapijska skupina: Antineoplastici, monoklonska protutijela, ATK oznaka: L01XC11.
English: Do not take any other medicines during your treatment without talking to your doctor first.
Croatian: Nemojte uzimati bilo koje druge lijekove za vrijeme liječenja a da se prethodno o tome niste posavjetovali sa svojim liječnikom.
English: A decrease in the weight of the thyroid and testes was seen in one study without accompanying histopathologic findings; the clinical relevance of this finding is unknown.
Croatian: Smanjenje težine štitne žlijezde i testisa vidjelo se u jednom ispitivanju bez popratnih patohistoloških nalaza; klinička važnost tog nalaza nije poznata.
English: The frequency is based on the program-wide exposure.
Croatian: Učestalost se temelji na izloženosti u širini programa ispitivanja.
English: Patients with cardiac or cardio-pulmonary symptoms should be assessed for potential myocarditis.
Croatian: Bolesnike sa srčanim ili srčano-plućnim simptomima treba ocijeniti zbog mogućeg miokarditisa.
English: The final concentration should range from 1 to 4 mg/ml.
Croatian: Konačna koncentracija treba biti između 1 i 4 mg/ml.
English: If there are signs of adrenal insufficiency but the patient is not in adrenal crisis, further investigations should be considered including laboratory and imaging assessment.
Croatian: Ukoliko postoje znakovi insuficijencije nadbubrežne žlijezde, ali bolesnik nije u adrenalnoj krizi, potrebno je razmotriti daljnje pretrage uključujući laboratorijske pretrage i metode oslikavanja.
English: These medicines may increase the likelihood of bleeding in the stomach or intestine, which is a sideeffect of YERVOY.
Croatian: Ti lijekovi mogu povećati vjerojatnost krvarenja u želudac ili crijeva, što su nuspojave lijeka YERVOY.
English: Clinical trials excluded patients with ECOG performance status > 1 and mucosal melanoma.
Croatian: Klinička ispitivanja isključila su bolesnike s ECOG izvedbenim statusom > 1 i melanomom sluznice.
English: If you stop using YERVOY
Croatian: Ako prestanete primati YERVOY
English: Within each frequency grouping, adverse reactions are presented in the order of decreasing seriousness.
Croatian: Unutar svake skupine po učestalosti, nuspojave su navedene u padajućem nizu prema ozbiljnosti.
English: Frequencies are defined as: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000), not known (cannot be estimated from available post-marketing data).
Croatian: Učestalost je definirana kao: vrlo često (≥ 1/10); često (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10000 i < 1/1000); vrlo rijetko (< 1/10 000); nepoznato (ne može se procijeniti iz dostupnih podataka nakon stavljanja lijeka u promet).
English: This can affect your ability to drive, cycle or to use machines.
Croatian: To može utjecati na Vašu sposobnost upravljanja vozilima, biciklom te rada na strojevima.
English: However, for women above 50 years of age, the data supporting an OS benefit of ipilimumab treatment were limited.
Croatian: Međutim, kod žena u dobi iznad 50 godina, podaci koji su pokazivali poboljšan OS zbog liječenja lijekom ipilimumab bili su ograničeni.
English: Ipilimumab should be avoided in patients with severe active autoimmune disease where further immune activation is potentially imminently life threatening.
Croatian: Ipilimumab treba izbjegavati u bolesnika s teškom aktivnom autoimunom bolešću kad postoji mogućnost da daljnja imunološka aktivacija neposredno ugrozi život.
English: It is available in packs containing either 1 glass vial of 10 ml or 1 glass vial of 40 ml.
Croatian: Dostupan je u pakiranjima s 1 staklenom bočicom od 10 ml ili 1 staklenom bočicom od 40 ml.
English: Based on early data, the combination of YERVOY (ipilimumab) and vemurafenib is not recommended due to increased toxicity to the liver.
Croatian: Na temelju ranijih podataka, kombinacija lijeka YERVOY (ipilimumab) i vemurafeniba, ne preporučuje se zbog povećane toksičnosti za jetru.
English: To dilute the YERVOY concentrate, you can use either:
Croatian: Za razrjeđenje koncentrata lijeka YERVOY, možete upotrijebiti:
English: Ipilimumab has been administered to approximately 10,000 patients in a clinical program evaluating its use with various doses and tumour types.
Croatian: Ipilimumab se primjenjivao u približno 10 000 bolesnika u kliničkom programu kojim se procjenjivala njegova primjena u različitim veličinama doza i vrstama tumora.
English: Advanced Melanoma and NonMelanoma Solid Tumors
Croatian: Uznapredovali melanom i nemelanomski solidni tumori
English: Two (25.0%) of 8 patients treated with 5 mg/kg and 1 (11.1%) of 9 patients treated with 10 mg/kg reported Grade 3-4 events.
Croatian: Dvoje (25,0 %) od 8 bolesnika liječenih s 5 mg/kg i 1 (11,1%) od 9 bolesnika liječenih s 10 mg/kg prijavili su događaje stupnja 3-4.
English: Uncommon mental status changes, depression, decreased libido Nervous system disorders
Croatian: Manje često promjena mentalnog statusa, depresija, smanjeni libido Poremećaji živčanog sustava
English: 14 months
Croatian: 14 mjeseci
English: Do not stop treatment with YERVOY unless you have discussed this with your doctor.
Croatian: Nemojte prekinuti liječenje lijekom YERVOY ako niste o tome prethodno razgovarali sa svojim liječnikom.
English: BORR was similar in the 10 mg/kg and 3 mg/kg groups.
Croatian: BORR je bio sličan u skupinama 10 mg/kg i 3 mg/kg.
English: Based on the simulation in adults and paediatrics, comparable exposure is achieved in adults and paediatrics at the recommended dose of 3 mg/kg every 3 weeks.
Croatian: Na temelju simulacije u odraslih i pedijatrijskih bolesnika usporediva izloženost postignuta je u odraslih i u pedijatrijskih bolesnika pri preporučenoj dozi od 3 mg/kg svaka 3 tjedna.
English: It is recommended to continue treatment with YERVOY in combination with nivolumab for clinically stable patients with initial evidence of disease progression until disease progression is confirmed.
Croatian: Preporučuje se nastaviti liječenje lijekom YERVOY u kombinaciji s nivolumabom u klinički stabilnih bolesnika s početnim znakovima progresije bolesti dok se progresija bolesti ne potvrdi.
English: YERVOY in combination with nivolumab may cause changes in the results of tests carried out by your doctor.
Croatian: YERVOY u kombinaciji s nivolumabom može uzrokovati promjene u nalazima pretraga koje provodi Vaš liječnik.
English: See section 4.4 for detailed management guidelines.
Croatian: Vidjeti dio 4.4 za detaljne smjernice za liječenje nuspojava.
English: In such patients, LFTs must be monitored until normalization.
Croatian: U takvih se bolesnika razine LFT moraju nadzirati do povratka na normalne vrijednosti.
English: Two patients treated with ipilimumab 10 mg/kg experienced a partial response, one of which was a durable response for more than 1 year.
Croatian: Dva bolesnika liječena ipilimumabom u dozi od 10 mg/kg doživjela su djelomični odgovor, jedan od kojih je imao odgovor u trajanju duljem od 1 godine.
English: Incidence rates per 100 person-years of exposure were 9.3 vs. 0; serious cardiac events were reported by 4.9% patients in the nivolumab group vs. 0 in the investigator´s choice group.
Croatian: Stopa incidencije na 100 bolesnik godina izloženosti iznosila je 9,3 naspram 0; ozbiljne srčane događaje prijavilo je 4,9% bolesnika u skupini liječenoj nivolumabom naspram 0 bolesnika u skupini koja je primala lijek po izboru ispitivača
English: Symptomatic treatment (e.g. loperamide, fluid replacement) and close monitoring are advised.
Croatian: Savjetuju se simptomatsko liječenje (npr. loperamid, nadoknada tekućine) i strogi nadzor.
English: If you become pregnant while using YERVOY tell your doctor.
Croatian: Ako zatrudnite za vrijeme primanja lijeka YERVOY, obavijestite o tome svog liječnika.
English: Immune-mediated adverse reactions were observed infrequently (~3%) and included colitis (which resulted in a single fatality), dermatitis, and infusion reaction (possibly due to acute cytokine release resulting from a rapid injection rate).
Croatian: Imunološki posredovane nuspojave nisu bile često primijećene (~3%), a uključivale su kolitis (koji je u jednom slučaju imao smrtni ishod), dermatitis i infuzijsku reakciju (moguće zbog akutnog oslobađanja citokina kao posljedice velike brzine injekcije).
English: The development or maintenance of clinical activity following ipilimumab treatment was similar with or without the use of systemic corticosteroids.
Croatian: Razvoj ili održavanje kliničke aktivnosti nakon liječenja ipilimumabom bili su slični bez obzira na primjenu sistemskih kortikosteroida.
English: Secretion of IgGs in human milk is generally limited and IgGs have a low oral bioavailability.
Croatian: Izlučivanje IgG protutijela u majčino mlijeko u ljudi općenito je ograničeno i IgG protutijela imaju nisku oralnu bioraspoloživost.
English: Treatment should be continued in the presence of hormone replacement therapya as long as no symptoms are present
Croatian: Liječenje treba nastaviti uz hormonsku nadomjesnu terapiju, pod uvjetom da nema nikakvih simptoma.
English: Most patients were male (58%) and white (92%).
Croatian: Većina bolesnika je bilo muškog spola (58%) i bijele rase (92%).
English: Permanent discontinuation of treatment or withholding of doses
Croatian: Trajni prekid liječenja ili odgađanje primjene doza
English: YERVOY is for intravenous use.
Croatian: Yervoy je namijenjen za intravensku primjenu.
English: Ipilimumab is a fully human anti-CTLA-4 monoclonal antibody (IgG1κ) produced in Chinese hamster ovary cells by recombinant DNA technology.
Croatian: Ipilimumab je potpuno ljudsko anti-CTLA-4 monoklonsko protutijelo (IgG1κ) proizvedeno u stanicama jajnika kineskog hrčka pomoću tehnologije rekombinantne DNK.
English: Assessment of tumour response to ipilimumab was conducted at approximately Week 12, after completion of induction therapy.
Croatian: Procjena tumorskog odgovora na ipilimumab provedena je približno u 12. tjednu, nakon završetka uvodne terapije.
English: In study CA184178, no new or unexpected irARs were observed, and the observed irARs were similar in frequency, intensity and organ site to what has been reported in adult studies.
Croatian: U ispitivanju CA184178 nisu zabilježeni novih ili neočekivani irAR-ovi, a oni zabilježeni irAR-ovi su po učestalosti, intenzitetu i organskom sustavu bili slični onim prijavljenim u ispitivanjima u odraslih.
English: Upon repeated dosing of ipilimumab administered every 3 weeks, CL was found to be time-invariant, and minimal systemic accumulation was observed as evident by an accumulation index 1.5 fold or less.
Croatian: Nakon ponovljene primjene ipilimumaba svaka 3 tjedna utvrđeno je da se klirens ne mijenja s vremenom te je opažena minimalna sistemska akumulacija, na što ukazuje indeks akumulacije od 1,5 puta ili manje.
English: if you have any history of inflammation of the lungs
Croatian: ako u povijesti bolesti imate upalu pluća
English: Hazard ratioa 99.8% CI p-valueb, c
Croatian: 99,8% CI p-vrijednostb, c
English: Patients with severe (Grade 3 or 4) endocrinopathy controlled with hormone replacement therapy may remain on therapy.
Croatian: Bolesnici s teškom (3. ili 4. stupnja) endokrinopatijom koja se kontrolira hormonskom nadomjesnom terapijom mogu ostati na terapiji.
English: All Deaths, n (%)
Croatian: Sve smrti, n (%)
English: No clinically relevant pharmacokinetic drug-drug interaction was observed between ipilimumab and paclitaxel/carboplatin, dacarbazine or its metabolite, 5-aminoimidazole-4-carboxamide (AIC).
Croatian: Nisu primijećene klinički značajne farmakokinetičke interakcije između ipilimumaba i paklitaksela/karboplatina, dakarbazina ili njegova metabolita, 5-aminoimidazol-4-karboksamida (AIC).
English: The use of anticoagulants is known to increase the risk of gastrointestinal haemorrhage.
Croatian: Poznato je da primjena antikoagulansa povećava rizik od gastrointestinalnog krvarenja.
English: An updated OS analysis was performed when all patients had a minimum follow-up of 24 months (see figure 7).
Croatian: Analiza ažuriranih podataka o OS-u provedena je kada su svi bolesnici bili praćeni najmanje 24 mjeseca (vidjeti Sliku 7).
English: Thus, the effect of ipilimumab on male and female fertility is unknown.
Croatian: Stoga nije poznat učinak ipilimumaba na plodnost u muškaraca i žena.
English: If you miss a dose of YERVOY
Croatian: Ako propustite dozu lijeka YERVOY