FrancophonIA/ELRC3.0 huggingface dataset:
English: AUC: ↑ 11 % (↑ 5 to ↑ 18) Cmax: ↑ 16 % (↑ 6 to ↑ 26) Cmin: ↑ 13 % (↑ 1 to ↑ 26) (CYP3A4 induction) The increase in efavirenz pharmacokinetic parameters is not considered clinically significant.
Slovenian: AUC: ↑ 11 % (↑ 5 do ↑ 18) Cmax: ↑ 16 % (↑ 6 do ↑ 26) Cmin: ↑ 13 % (↑ 1 do ↑ 26) (indukcija CYP3A4) Povečanje farmakokinetičnih parametrov efavirenza se ne smatra za klinično pomembno.
English: rare delusion
Slovenian: redki privid
English: AUC: ↑ 20 % (↑ 8 to ↑ 34) Cmax: ↑ 21 % (↑ 10 to ↑ 33) The combination was generally well tolerated.
Slovenian: AUC: ↑ 20 % (↑ 8 do ↑ 34) Cmax : ↑ 21 % (↑ 10 do ↑ 33) Kombinacijo so na splošno dobro prenašali.
English: These are listed under Do not take Stocrin, at the start of Section 2.
Slovenian: Ta zdravila so našteta na začetku 2. poglavja pod naslovom Ne jemljite zdravila Stocrin.
English: Carbamazepine may make Stocrin less likely to work.
Slovenian: Karbamazepin lahko zmanjša delovanje zdravila Stocrin.
English: The AUC and Cmax of a single 240 mg dose of efavirenz oral solution in uninfected adult volunteers was increased by 30 % and 43 % respectively, when given with a high-fat meal, relative to fasted conditions.
Slovenian: Pri neokuženih odraslih prostovoljcih sta bili AUC in Cmax 240 mg odmerka peroralne raztopine ob obroku z veliko maščobami povečani za 30 % oziroma 43 % v primerjavi z vrednostma na tešče.
English: AUC: ↑ 7 % (↑ 1 to ↑ 14) Cmax: ↑ 16 % (↑ 2 to ↑ 32) These changes are not considered clinically significant.
Slovenian: AUC: ↑ 7 % (↑ 1 do ↑ 14) Cmax: ↑ 16 % (↑ 2 do ↑ 32) Ti spremembi se ne smatrata za klinično pomembni.
English: STOCRIN 50 mg film-coated tablets Yellow, round, debossed with “113” on one side.
Slovenian: STOCRIN 50 mg filmsko obložene tablete Rumene, okrogle, z oznako "113" na eni strani.
English: If you have taken Stocrin or the combination tablet containing efavirenz, emtricitabine, and tenofovir during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Slovenian: Če zdravilo Stocrin ali kombinirane tablete, ki vsebujejo efavirenz, emtricitabin in tenofovir, jemljete med nosečnostjo, bo zdravnik morda naročil redne krvne preiskave in druge diagnostične teste za spremljanje razvoja otroka.
English: Rapid squirting into the mouth may cause choking.
Slovenian: Prehiter iztis lahko povzroči dušenje.
English: Decreased exposure of etonogestrel may be expected (CYP3A4 induction).
Slovenian: Lahko pričakujemo zmanjšano izpostavitev etonogestrelu (indukcija CYP3A4).
English: Rash was reported in 26 of 57 children (46 %) treated with efavirenz during a 48-week period and was severe in three patients.
Slovenian: O izpuščaju so poročali pri 26 od 57 otrok (46 %), zdravljenih z efavirenzem v obdobju 48 tednov.
English: Elbasvir/grazoprevir
Slovenian: elbasvir/grazoprevir elbasvir:
English: Each carton contains 1 bottle of 30 film-coated tablets.
Slovenian: Ena škatla vsebuje 1 plastenko s 30 filmsko obloženimi tabletami.
English: • The dose for children weighing 40 kg or more is 24 ml once daily.
Slovenian: • Odmerek za otroke, ki tehtajo 40 kg ali več, je 24 ml enkrat na dan.
English: When taken with rifampicin in patients weighing 50 kg or greater, increasing efavirenz daily dose to 800 mg may provide exposure similar to a daily dose of 600 mg, when taken without rifampicin.
Slovenian: Pri bolnikih s telesno maso 50 kg ali več je pri jemanju z rifampicinom pri povečanju dnevnega odmerka efavirenza na 800 mg izpostavitev podobna kot pri dnevnem odmerku 600 mg, če bolnik ne jemlje rifampicina.
English: (500/125 mg twice daily/600 mg once daily)
Slovenian: (500/125 mg dvakrat na dan/600 mg enkrat na dan)
English: Individuals with these conditions may take efavirenz oral solution, which is free from lactose.
Slovenian: Posamezniki s temi stanji lahko jemljejo peroralno raztopino efavirenza, ki ne vsebuje laktoze.
English: Outer carton: STOCRIN 600 mg
Slovenian: Škatla: STOCRIN 600 mg
English: The increased efavirenz concentrations observed following administration of STOCRIN with food may lead to an increase in frequency of adverse reactions (see sections 4.4 and 5.2).
Slovenian: Povišana koncentracija efavirenza, ki so jo opazili po zaužitju zdravila STOCRIN s hrano, lahko vodi do povečane pogostnosti neželenih učinkov (glejte poglavji 4.4 in 5.2).
English: AUC: ↑ 21 % (↑ 10 to ↑ 34) Cmax: ↑ 14 % (↑ 4 to ↑ 26) Cmin: ↑ 25 % (↑ 7 to ↑ 46) (inhibition of CYP-mediated oxidative metabolism) When efavirenz was given with ritonavir 500 mg or 600 mg twice daily, the combination was not well tolerated (for example, dizziness, nausea, paraesthesia and elevated liver enzymes occurred).
Slovenian: Cmax: ↑ 14 % (↑ 4 do ↑ 26) Cmin: ↑ 25 % (↑ 7 do ↑ 46) (zaviranje oksidativne presnove, pri kateri sodelujejo encimi CYP) Kadar so efavirenz dajali skupaj s 500 mg ali 600 mg ritonavirja dvakrat na dan, bolniki te kombinacije niso dobro prenašali (pojavili so se na primer omotica, navzea, parestezija in zvišane vrednosti jetrnih encimov).
English: Cmax: ↑ 11 % (↑ 3 to ↑ 19) (CYP3A4 induction) Rash developed in 46 % of uninfected volunteers receiving efavirenz and clarithromycin.
Slovenian: Cmax: ↑ 11 % (↑ 3 do ↑ 19) (indukcija CYP3A4) Pri 46 % neokuženih prostovoljcih se je med jemanjem efavirenza in klaritromicina pojavil izpuščaj.
English: - if you have a history of convulsions (fits or seizures) or if you are being treated with anticonvulsant therapy such as carbamazepine, phenobarbital and phenytoin.
Slovenian: če ste v preteklosti imeli konvulzije (napade krčev) ali prejemate zdravila proti krčem, kot so karbamazepin, fenobarbital in fenitoin.
English: This mutation was observed in 90 % of patients receiving efavirenz with virological failure.
Slovenian: To mutacijo so opazili pri 90 % bolnikov, ki so prejemali efavirenz, vendar se niso odzvali na zdravljenje.
English: Medicines used to lower blood fats (also called statins):atorvastatin, pravastatin, simvastatin.
Slovenian: Zdravila za znižanje maščob v krvi (imenovana tudi statini):atorvastatin, pravastatin, simvastatin.
English: This loss is due to significant decreases in elbasvir and grazoprevir plasma concentrations caused by CYP3A4 or P-gp induction (refer to the Summary of Product Characteristics for elbasvir/grazoprevir for additional information).
Slovenian: Ta izguba virološkega odziva nastopi zaradi pomembnih znižanj plazemskih koncentracij elbasvirja in grazoprevirja, ki ga povzroči indukcija CYP3A4 ali P-gp (za dodatne informacije glejte Povzetek glavnih značilnosti zdravila za elbasvir/grazoprevir).
English: Liver enzymes: elevations of AST and ALT to greater than five times the upper limit of the normal range (ULN) were seen in 3 % of 1,008 patients treated with 600 mg of efavirenz (5-8 % after longterm treatment in study 006).
Slovenian: Jetrni encimi: povišanje AST in ALT na več kot petkratno zgornjo mejo normalnih vrednosti (ZMN) so opazili pri 3 % od 1.008 bolnikov, zdravljenih s 600 mg efavirenza (5-8 % po dolgotrajnem zdravljenju v študiji 006).
English: • if you are currently taking any of the following medicines (see also “Other medicines and Stocrin”): - astemizole or terfenadine (used to treat allergy symptoms) - bepridil (used to treat heart disease) - cisapride (used to treat heartburn) - ergot alkaloids (for example, ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (used to treat migraine and cluster headaches) - midazolam or triazolam (used to help you sleep) - pimozide, imipramine, amitriptyline or clomipramine (used to treat certain mental conditions) - St. John's wort (Hypericum perforatum) (a herbal remedy used for depression and anxiety) - flecainide, metoprolol (used to treat irregular heart beat) - certain antibiotics (macrolides, fluoroquinolones, imidazole) - triazole antifungal agents - certain antimalarial treatments - methadone (used to treat opiate addiction) - elbasvir/grazoprevir
Slovenian: • če trenutno jemljete katero koli od naslednjih zdravil (glejte tudi "Druga zdravila in zdravilo Stocrin"): - astemizol ali terfenadin (za zdravljenje alergijskih simptomov) - bepridil (za zdravljenje bolezni srca) - cisaprid (za zdravljenje zgage) - ergot alkaloide (kot na primer ergotamin, dihidroergotamin, ergonovin in metilergonovin) (za zdravljenje migrene in klaster glavobolov) - midazolam ali triazolam (uporabljata se za lažje spanje) - pimozid, imipramin, amitriptilin ali klomipramin (za zdravljenje določenih duševnih stanj) - šentjanževko (Hypericum perforatum) (rastlinski pripravek, ki se uporablja pri depresiji in tesnobi) - flekainid, metoprolol (uporabljata se za zdravljenje nerednega srčnega utripa) - določene antibiotike (makrolidi, fluorokinoloni, imidazoli) - triazolske antimikotike - določene antimalarike - metadon (uporablja se za zdravljene odvisnosti od opiatov) - elbasvir/grazoprevir
English: STOCRIN 200 mg film-coated tablets Yellow, round, debossed with “223” on one side.
Slovenian: STOCRIN 200 mg filmsko obložene tablete Rumene, okrogle, z oznako "223" na eni strani.
English: < 400 copies/ml (95 % C.I.
Slovenian: < 400 kopij/ml (95-odstotni IZ
English: The dose of Stocrin oral solution must be measured using the oral syringe supplied in the carton.
Slovenian: Odmerek peroralne raztopine Stocrin morate odmeriti s pomočjo brizge za peroralno dajanje, ki je priložena v škatli.
English: AUC: ↓ 36 % C12: ↓ 21 % Cmax: ↓ 36 % (UGT1A1 induction)
Slovenian: AUC: ↓ 36 % C12: ↓ 21 % Cmax: ↓ 36 % (indukcija UGT1A1)
English: Among co-infected patients in study 006, elevations in AST to greater than five times ULN developed in 13 % of efavirenz treated patients and in 7 % of controls, and elevations in ALT to greater than five times ULN developed in 20 % and 7 % respectively.
Slovenian: Med sočasno okuženimi bolniki v študiji 006 je prišlo do zvišanj AST, večjih od petkratne ZMN, pri 13 % bolnikov, zdravljenih z efavirenzem, in pri 7 % bolnikov v kontrolni skupini, ter do zvišanj ALT, večjih od petkratne ZMN, pri 20 % bolnikov, zdravljenih z efavirenzem, ter pri 7 % bolnikov v kontrolni skupini.
English: atovaquone/proguanil: Stocrin may reduce the amount of atovaquone/proguanil in your blood.
Slovenian: atovakon/progvanil: zdravilo Stocrin lahko zmanjša količino atovakona/progvanila v krvi.
English: (400/100 mg twice daily/600 mg once daily)
Slovenian: (400/100 mg dvakrat na dan/600 mg enkrat na dan)
English: False-positive urine cannabinoid test results have been reported with some screening assays in uninfected and HIV-infected subjects receiving efavirenz.
Slovenian: Z nekaterimi presejalnimi testi so pri neokuženih in z virusom HIV okuženih prostovoljcih, ki so prejemali efavirenz, poročali o lažno pozitivnem rezultatu urinskega kanabinoidnega testa.
English: Excipient with known effect Each film-coated tablet contains 249.6 mg of lactose (as monohydrate).
Slovenian: Pomožna snov z znanim učinkom Ena filmsko obložena tableta vsebuje 249,6 mg laktoze (v obliki monohidrata).
English: If efavirenz is coadministered with voriconazole, the voriconazole maintenance dose must be increased to 400 mg every 12 hours and the efavirenz dose must be reduced by 50 %, i.e., to 300 mg once daily.
Slovenian: Če se efavirenz uporablja sočasno z vorikonazolom, je treba vzdrževalni odmerek vorikonazola povečati na 400 mg na vsakih 12 ur, odmerek efavirenza pa zmanjšati za 50 %, to je na 300 mg enkrat na dan.
English: Sofosbuvir/velpatasvir sofosbuvir/velpatasvir/voxilaprevir
Slovenian: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/voksilaprevir sofosbuvir: Cmax ↑ 38 %
English: AUC : ↓ 13 % Cmin : ↓ 31 % Cmax: ↓ 15% (CYP3A4 induction) Efavirenz:
Slovenian: AUC : ↓ 13 % Cmin : ↓ 31 % Cmax: ↓ 15 % (indukcija CYP3A4) efavirenz:
English: Liver enzymes in hepatitis B or C co-infected patients In the long-term data set from study 006, 137 patients treated with efavirenz-containing regimens (median duration of therapy, 68 weeks) and 84 treated with a control regimen (median duration, 56 weeks) were seropositive at screening for hepatitis B (surface antigen positive) and/or C (hepatitis C antibody positive).
Slovenian: Jetrni encimi pri bolnikih, sočasno okuženih s hepatitisom B ali C Po dolgoročnih podatkih iz študije 006 je bilo ob presejanju seropozitivnih na hepatitis B (pozitivnih na površinski antigen) in/ali C (pozitivnih na protitelo proti hepatitisu C) 137 bolnikov na režimu, ki je vseboval efavirenz (mediana vrednost časa trajanja zdravljenja 68 tednov), in 84 bolnikov na kontrolnem režimu (mediana vrednost časa trajanja 56 tednov).
English: Fosamprenavir/Nelfinavir/Efavirenz Interaction not studied
Slovenian: fosamprenavir/nelfinavir/efavirenz Interakcij niso preučevali.
English: AUC : ↑ 21 % Cmin: ↑ 17 % Cmax: ↑ 15% (CYP3A4 inhibition)
Slovenian: AUC : ↑ 21 % Cmin: ↑ 17 % Cmax: ↑ 15 % (inhibicija CYP3A4)
English: • The other ingredients are: medium chain triglycerides, benzoic acid (E210) and strawberry/mint flavour.
Slovenian: • Pomožne snovi so: srednjeverižni nasičeni trigliceridi, benzojska kislina (E210) ter aroma jagode/mete.
English: Outer carton: STOCRIN 30 mg/ml
Slovenian: Škatla: STOCRIN 30 mg/ml
English: What Stocrin contains
Slovenian: Kaj vsebuje zdravilo Stocrin
English: AUC: ↓ 31 % (↓ 8 to ↓ 47) Cmin: ↓ 40 %
Slovenian: AUC: ↓ 31 % (↓ 8 do ↓ 47) Cmin: ↓ 40 %
English: The bottle of Stocrin oral solution should be used within one month after first opening.
Slovenian: Peroralno raztopino Stocrin porabite v enem mesecu po odprtju plastenke.
English: Cmax: ↓ 44% (↓ 20 to ↓ 61)
Slovenian: Cmax: ↓ 44 % (↓ 20 do ↓ 61)
English: Each ml contains 30 mg of efavirenz.
Slovenian: En ml vsebuje 30 mg efavirenza.
English: Co-administration with elbasvir/grazoprevir due to the expected significant decreases in elbasvir and grazoprevir plasma concentrations (see section 4.5).
Slovenian: Sočasna uporaba z elbasvirjem/grazoprevirjem zaradi pričakovanega pomembnega znižanja plazemskih koncentracij elbasvirja in grazoprevirja (glejte poglavje 4.5).
English: In HIV infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Pri z virusom HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo se lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART) pojavi vnetna reakcija na asimptomatične ali rezidualne oportunistične okužbe.
English: AUC: ↓ 52 % (↓ 33 to ↓ 66) Cmax: ↓ 45 % (↓ 25 to ↓ 59) (CYP3A4 induction) In a study of HIV infected intravenous drug users, co-administration of efavirenz with methadone resulted in decreased plasma levels of methadone and signs of opiate withdrawal.
Slovenian: AUC: ↓ 52 % (↓ 33 do ↓ 66) Cmax: ↓ 45 % (↓ 25 do ↓ 59) (indukcija CYP3A4) V študiji pri uživalcih intravenskih drog, okuženih z virusom HIV, je sočasna uporaba efavirenza in metadona povzročila zmanjšanje ravni metadona v plazmi in znake odtegnitve od opiatov.
English: < 50 copies/ml (95 % C.I.
Slovenian: < 50 kopij/ml (95-odstotni IZ
English: Peak efavirenz plasma concentrations of 1.6 - 9.1 M were attained by 5 hours following single oral doses of 100 mg to 1,600 mg administered to uninfected volunteers.
Slovenian: Maksimalne plazemske koncentracije efavirenza, 1,6 - 9,1 M, so bile pri neokuženih prostovoljcih dosežene 5 ur po dajanju enkratnih peroralnih odmerkov 100 mg do 1.600 mg. Od odmerka odvisna zvišanja Cmax in AUC so opazili pri odmerkih do 1.600 mg.
English: Grapefruit juice should be avoided when taking Stocrin.
Slovenian: Med jemanjem zdravila Stocrin se je potrebno izogibati uživanju soka grenivke.
English: STOCRIN 600 mg film-coated tablets Dark yellow, capsule-shaped, debossed with “225” on one side.
Slovenian: STOCRIN 600 mg filmsko obložene tablete Temno rumene barve, v obliki kapsule, z oznako " 225" na eni strani.
English: AUC: ↓ 83 % (↓ 79 to ↓ 87) Cmax: ↓ 80 % (↓ 77 to ↓ 83) Cmin: ↓ 86 % (↓ 80 to ↓ 90) (induction of metabolism) Efavirenz: no clinically significant interaction.
Slovenian: AUC: ↓ 83 % (↓ 79 do ↓ 87) Cmax: ↓ 80 % (↓ 77 do ↓ 83) Cmin: ↓ 86 % (↓ 80 do ↓ 90) (indukcija presnove) efavirenz: Ni klinično pomembnih interakcij.
English: Individuals with these conditions may take Stocrin oral solution, which is free from lactose.
Slovenian: Posamezniki s temi stanji lahko uporabljajo peroralno raztopino zdravila Stocrin, ki ne vsebuje laktoze.
English: STOCRIN 600 mg film-coated tablets STOCRIN 50 mg film-coated tablets STOCRIN 200 mg film-coated tablets
Slovenian: STOCRIN 600 mg filmsko obložene tablete STOCRIN 50 mg filmsko obložene tablete STOCRIN 200 mg filmsko obložene tablete
English: AUC: ↔* (↓ 9 to ↑ 10) Cmax: ↑ 17 %* (↑ 8 to ↑ 27) Cmin: ↓ 42 %* (↓ 31 to ↓ 51)
Slovenian: AUC: ↔* (↓ 9 do ↑ 10) Cmax: ↑ 17 %* (↑ 8 do ↑ 27) Cmin : ↓ 42 %* (↓ 31 do
English: Co-administration of STOCRIN with sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/voxilaprevir is not recommended (refer to the Summary of Product Characteristics for sofosbuvir/velpatasvir and sofosbuvir/velpatasvir/voxilaprevir for additional information).
Slovenian: Sočasna uporaba zdravila STOCRIN s sofosbuvirjem/velpatasvirjem ali sofosbuvirjem/velpatasvirjem/ voksilaprevirjem ni priporočljiva (za dodatne informacije glejte Povzetek glavnih značilnosti zdravila za sofosbuvir/velpatasvir in sofosbuvir/velpatasvir/voksilaprevir).
English: Approximately 14 - 34 % of a radiolabelled dose of efavirenz was recovered in the urine and less than 1 % of the dose was excreted in urine as unchanged efavirenz.
Slovenian: Približno 14 - 34 % radiooznačenega odmerka efavirenza se je izločilo z urinom.
English:  Efavirenz 50 mg, 200 mg and 600 mg film-coated tablets are available.
Slovenian: *Na voljo so 50 mg, 200 mg in 600 mg filmsko obložene tablete efavirenza.
English: No child had severe symptoms or had to discontinue because of nervous system symptoms.
Slovenian: Hudih simptomov ni imel noben otrok.
English: Excipient with known effect Each film-coated tablet contains 20.8 mg of lactose (as monohydrate).
Slovenian: Pomožna snov z znanim učinkom Ena filmsko obložena tableta vsebuje 20,8 mg laktoze (v obliki monohidrata).
English: Co-administration of glecaprevir/pibrentasvir with efavirenz is not recommended (see section 4.5).
Slovenian: Sočasne uporabe efavirenza in glekaprevira/pibrentasvira ne priporočamo (glejte poglavje 4.5).
English: AUC: ↑ 17 % (↑ 6 to ↑ 29) ** Cmax: ↔** *compared to 200 mg twice daily alone ** compared to 600 mg once daily alone (competitive inhibition of oxidative metabolism)
Slovenian: Cmax: ↔ ** *v primerjavi z 200 mg samim dvakrat na dan **v primerjavi s 600 mg samim enkrat na dan (kompetitivno zaviranje oksidativne presnove)
English: Stocrin may reduce the amount of itraconazole in your blood.
Slovenian: Zdravilo Stocrin lahko zmanjša količino itrakonazola v krvi.
English: Cmax: ↑ 11 % (↑ 6 to ↑ 16) Cmin: ↔ (CYP3A4 induction)
Slovenian: Cmax: ↑ 11 % (↑ 6 do ↑ 16) Cmin: ↔ (indukcija CYP3A4)
English: Responder rates (NC = F Plasma HIV-RNA
Slovenian: Delež bolnikov, ki so se odzvali na zdravljenje (NK = NA plazemska HIV-RNA
English: Cmin: ↓ 12 % (↓ 24 to ↑ 1) (CYP3A4 induction)
Slovenian: Cmin: ↓ 12 % (↓ 24 do ↑ 1) (indukcija CYP3A4)
English: Lopinavir concentrations: similar to lopinavir/ritonavir 400/100 mg twice daily without efavirenz
Slovenian: Koncentracije lopinavirja: podobne kot pri lopinavirju/ritonavirju 400/100 mg dvakrat na dan brez efavirenza
English: Stocrin may reduce the amount of voriconazole in your blood and voriconazole may increase the amount of Stocrin in your blood.
Slovenian: Zdravilo Stocrinlahko zmanjša količino vorikonazola v krvi, vorikonazol pa lahko poveča količino zdravila Stocrin v krvi.
English: Excipient with known effect Each film-coated tablet contains 83.2 mg of lactose (as monohydrate).
Slovenian: Pomožna snov z znanim učinkom Ena filmsko obložena tableta vsebuje 83,2 mg laktoze (v obliki monohidrata).
English: Sertraline(a medicine used to treat depression):your doctor may need to change your dose of sertraline.
Slovenian: Sertralin (zdravilo za zdravljenje depresije):zdravnikvam bo morda spremenil odmerek sertralina.
English: Implant: Etonogestrel/Efavirenz
Slovenian: vsadek: etonogestrel/efavirenz
English: In uninfected volunteers, multiple doses of 200 - 400 mg per day for 10 days resulted in a lower than predicted extent of accumulation
Slovenian: Pri neokuženih prostovoljcih so 10-dnevni večkratni odmerki 200 - 400 mg na dan povzročili manjšo akumulacijo zdravila od pričakovane (22 - 42 % manjšo) in krajši končni razpolovni čas v primerjavi z enkratnim odmerkom
English: AUC: ↓ 4 % (↓ 0 to ↓ 31) Cmax: ↓ 47 % (↓ 9 to ↓ 51) Total active HMG Co-A reductase inhibitors:
Slovenian: AUC: ↓ 4 % (↓ 0 do ↓ 31) Cmax: ↓ 47 % (↓ 9 do ↓ 51) skupni aktivni zaviralci HMG Co-A-reduktaze:
English: Efavirenz must not be administered concurrently with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil, or ergot alkaloids (for example, ergotamine, dihydroergotamine, ergonovine, and methylergonovine) since inhibition of their metabolism may lead to serious, life-threatening events (see section 4.3).
Slovenian: Efavirenza se ne sme jemati hkrati s terfenadinom, astemizolom, cisapridom, midazolamom, triazolamom, pimozidom, bepridilom ali ergot alkaloidi (npr. ergotaminom, dihidroergotaminom, ergonovinom in metilergonovinom), ker zaviranje njihovega metabolizma lahko povzroči resne, življenje ogrožajoče neželene učinke (glejte poglavje 4.3).
English: Fosamprenavir/Saquinavir/Efavirenz Interaction not studied
Slovenian: fosamprenavir/sakvinavir/efavirenz Interakcij niso preučevali.
English: Stevens-Johnson syndrome) - yellow skin or eyes, itching, or pain in the abdomen (stomach) caused by inflammation of the liver - breast enlargement in males - angry behaviour, mood being affected, seeing or hearing things that are not really there
Slovenian: - porumenelost kože ali oči, srbenje ali bolečina v trebuhu (želodcu) zaradi vnetja jeter - povečanje prsi pri moških - jeza, vpliv na razpoloženje, videnje ali slišanje stvari, ki jih v resnici ni (halucinacije), manija
English: Injection: Depo-medroxyprogesterone acetate (DMPA)/Efavirenz (150 mg IM single dose DMPA)
Slovenian: Priporočilo glede sočasne uporabe z efavirenzem injekcija: depomedroksiprogesteronacetat (DMPA)/efavirenz (150 mg i.m.
English: • Separate the syringe from the adapter.
Slovenian: • Odstranite brizgo iz nastavka.
English: If you are taking any of these medicines, your doctor may need to check the level of anticonvulsant medicine in your blood to ensure that it is not affected while taking Stocrin.
Slovenian: Če jemljete katero od naštetih zdravil, vam bo zdravnik morda preveril količino zdravila proti krčem v krvi.
English: The recommended dose of efavirenz in combination with a PI and/or NRTIs for patients between 3 and 17 years of age is described in Table 1.
Slovenian: V kombinaciji z ZP in/ali NRTI-ji so priporočeni odmerki efavirenza za bolnike, stare od 3 do 17 let, navedeni v preglednici 1.
English: Stocrin can reduce or increase the amount of anticonvulsant in your blood.
Slovenian: Zdravilo Stocrin lahko zmanjša ali poveča količino zdravila proti krčem v krvi.
English: When efavirenz is co-administered with voriconazole, the voriconazole maintenance dose must be increased to 400 mg twice daily and the efavirenz dose must be reduced by 50 %, i.e., to 300 mg once daily.
Slovenian: Pri sočasni uporabi efavirenza in vorikonazola je treba vzdrževalni odmerek vorikonazola povečati na 400 mg dvakrat na dan, odmerek efavirenza pa zmanjšati za 50 %, to je na 300 mg enkrat na dan.
English: Artemether/lumefantrine/ Efavirenz (20/120 mg tablet, 6 doses of 4 tablets each over 3 days/600 mg once daily)
Slovenian: Antimalariki artemeter/lumefantrin/ efavirenz (20/120 mg tablete, 6 odmerkov po 4 tablete v 3 dneh /600 mg enkrat na dan)
English: If you are affected your doctor may suggest that you take Stocrin at bedtime.
Slovenian: Če se pojavijo pri vas, vam bo zdravnik morda svetoval, da zdravilo Stocrin jemljete pred spanjem.
English: EFV + IDV + NRTIs IDV + NRTIs
Slovenian: EFV + IDV + NRTI-ji IDV + NRTI-ji a
English: Draw the warm soapy water into the syringe until full and then empty completely.
Slovenian: Brizgo napolnite z milnico in jo izpraznite.