FrancophonIA/ELRC3.0 huggingface dataset:
English: There are no clinical data available regarding potential effects of doripenem treatment on male or female fertility.
Slovenian: Študije na podganah in zajcih ne kažejo toksičnega vpliva na sposobnost razmnoževanja.
English: Vascular disorders
Slovenian: Pseudomonas aeruginosa*
English: ‡ Defined as event that occurred between 00:00 and 05:59 hours.
Slovenian: ‡ Opredeljeno kot dogodek, ki se je pojavil od 00:00 do 05:59 ure.
English: Efficacy over a 52-week period
Slovenian: Učinkovitost v 52-tedenskem obdobju
English: Patients should be monitored and treated as appropriate.
Slovenian: Bolnike je treba kontrolirati in zdraviti, kot je ustrezno.
English: Insulin optimisation was continued throughout the study.
Slovenian: Optimizacijo insulina so nadaljevali med celotno študijo.
English: Patients with hypovolemia may be more susceptible to these changes.
Slovenian: Bolniki s hipovolemijo so lahko za te spremembe bolj dovzetni.
English: N: all randomised and treated patients
Slovenian: N: vsi randomizirani in zdravljeni bolniki
English: Ketone levels should be measured again after two hours.
Slovenian: Koncentracijo ketonov je treba znova izmeriti po dveh urah.
English: Your doctor will prescribe the dose that is right for you.
Slovenian: Zdravnik vam bo predpisal odmerek, ki je pravi za vas.
English: Zynquista should not be used during the last six months of pregnancy.
Slovenian: Zdravila Zynquista se ne sme uporabljati v zadnjih šestih mesecih nosečnosti.
English: No clinically relevant differences were noted between the two populations.
Slovenian: Klinično pomembnih razlik med tema populacijama niso opazili.
English: These changes were not considered relevant for humans as TSH is not carcinogenic in humans.
Slovenian: Te spremembe ne veljajo za pomembne za človeka, ker TSH pri človeku ni karcinogen.
English: In particular, tell your doctor if you are taking any of the following medicines:
Slovenian: Še zlasti morate zdravniku povedati, če jemljete katero od naslednjih zdravil:
English: • Signs/symptoms of DKA.
Slovenian: • Znaki/simptomi DKA.
English: Information for the patient:
Slovenian: Informacije za bolnika:
English: It should be evaluated if additional safety monitoring is needed when using these substrates.
Slovenian: Oceniti je treba, ali je med uporabo teh substratov potreben dodaten nadzor glede varnosti.
English: o Is willing/able to perform ketone testing as prescribed.
Slovenian: o pripravljen/sposoben izvajati testiranje ketonov, kot je predpisano.
English: * 5.35% more time in range, correspond to 1.3 hours † 11.71% more time in range, correspond to 2.8 hours
Slovenian: * 5,35 % več časa v razponu; to ustreza 1,3 ure † 11,71 % več časa v razponu; to ustreza 2,8 ure
English: Poly(vinyl alcohol) Macrogol
Slovenian: Poli(vinil alkohol) Makrogol
English: This leaflet was last revised in. Other sources of information
Slovenian: Navodilo je bilo nazadnje revidirano dne Drugi viri informacij
English: Your doctor will decide whether to increase your dose to 400 mg once a day.
Slovenian: Zdravnik bo presodil, ali vam je treba odmerek povečati na 400 mg enkrat na dan.
English: In study 1, a total of 793 patients entered the study.
Slovenian: V študijo 1 je vstopilo skupno 793 bolnikov.
English: Talk to your doctor about the best way to control your blood sugar while you are pregnant.
Slovenian: Z zdravnikom se posvetujte, kako najbolje obvladati krvni sladkor med nosečnostjo.
English: A double dose should not be taken on the same day.
Slovenian: Bolnik ne sme vzeti dveh odmerkov na isti dan.
English: Zynquista is not recommended for children and adolescents under 18 years of age, because it has not been studied in these patients.
Slovenian: Zdravila Zynquista ni priporočljivo uporabljati pri otrocih in mladostnikih, mlajših od 18 let, ker pri teh bolnikih zdravilo ni raziskano.
English: • if you are allergic to sotagliflozin or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični na sotagliflozin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: Do not use this medicine after the expiry date which is stated on the carton after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli poleg oznake "EXP".
English: Each study was of 52 weeks duration, with primary and key secondary endpoints at 24 weeks.
Slovenian: Obe študiji sta trajali 52 tednov, primarne in sekundarne končne opazovane dogodke pa so ugotavljali po 24 tednih.
English: This is a rare but serious and potentially life-threatening event that requires urgent surgical intervention and antibiotic treatment.
Slovenian: To je redek, toda resen in potencialno smrtno nevaren pojav, ki zahteva nujno kirurško oskrbo in antibiotično zdravljenje.
English: Information for healthcare professionals:
Slovenian: Informacije za zdravstvene delavce:
English: Elimination/excretion
Slovenian: Odstranjevanje/izločanje
English: Do not use this medicine if you notice that the packaging is damaged or shows signs of tampering.
Slovenian: Ne uporabite tega zdravila, če opazite, da je pakiranje poškodovano, ali kaže znake, da ga je že kdo odpiral.
English: Substrates of these enzymes should be monitored for decreases in efficacy.
Slovenian: Substrate teh encimov je treba nadzirati glede zmanjšanja učinkovitosti.
English: Follow your doctor's instructions on taking these other medicine(s) to achieve the best results for your health.
Slovenian: Upoštevajte zdravnikova navodila za jemanje tega zdravila/teh zdravil, da boste dosegli najboljše izide za svoje zdravje.
English: rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Slovenian: 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), ni znano (ni mogoče oceniti na podlagi podatkov, ki so na voljo).
English: 2-hour postprandial glucose following a standardized mixed meal, mmol/L
Slovenian: Postprandialna glukoza 2 uri po standardiziranem mešanem obroku, mmol/l
English: Component of a multipack, can't be sold separately.
Slovenian: Del pakiranja po več enot, ni za ločeno prodajo.
English: - Patients unable or unwilling to monitor ketones.
Slovenian: - ki niso zmožni ali niso voljni kontrolirati ketone.
English: Fournier´s gangrene has to be treated immediately.
Slovenian: Fournierjeva gangrena nemudoma zahteva zdravljenje.
English: HbA1c (%)
Slovenian: N HbA1c (%)
English: - Prior to initiation of concomitant medicinal products that may reduce renal function and periodically thereafter.
Slovenian: - Pred uvedbo sočasne terapije z zdravili, ki lahko oslabijo ledvično funkcijo in periodično v nadaljevanju.
English: Manufacturer :
Slovenian: Izdelovalec:
English: Table 1: Actions to take in case of elevated ketone levels
Slovenian: Preglednica 1: Ukrepanje v primeru zvišane koncentracije ketonov
English: Adverse reactions listed below are classified according to frequency and system organ class (SOC).
Slovenian: Spodaj našteti neželeni učinki so razvrščeni po pogostnosti in organskem sistemu (SOC - system organ class).
English: Necrotising fasciitis of the perineum (Fournier's gangrene)
Slovenian: Nekrotizirajoči fascitis perineja (Fournierjeva gangrena)
English: The MAH shall ensure that in each Member State where sotagliflozin is marketed, all healthcare professionals and patients/carers who are expected to prescribe, dispense or use the product have access to:
Slovenian: Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da bodo v vseh državah članicah, kjer se sotagliflozin trži, vsi zdravstveni delavci in bolniki/skrbniki, za katere se pričakuje, da bodo predpisovali, izdajali ali uporabljali zdravilo, imeli dostop do:
English: The recommended actions are listed in Table 1.
Slovenian: Priporočeni ukrepi so navedeni v preglednici 1.
English: The safety and efficacy of sotagliflozin in children and adolescents has not yet been established.
Slovenian: Pediatrična populacija Učinkovitost in varnost sotagliflozina pri otrocih in mladostnikih še nista ugotovljeni.
English: - Patients with excessive alcohol consumption or who use illicit drugs.
Slovenian: - ki prekomerno uživajo alkohol ali uporabljajo prepovedane snovi.
English: • Summary of the recommendations for patients, particularly regarding blood ketone measurement and managing sick days.
Slovenian: • Povzetek priporočil za bolnike, zlasti v zvezi z merjenjem ketonov v krvi in vodenjem bolniških odsotnosti.
English: Insulin may increase the risk of hypoglycaemia.
Slovenian: Insulin lahko poveča tveganje za hipoglikemijo.
English: • Contact details of the sotagliflozin ‘prescriber' and ‘Name of patient'.
Slovenian: • Kontaktni podatki „zdravnika, ki je predpisal“ sotagliflozin in „ime bolnika“.
English: N/A 5.35 (0.026)* 11.71 (<0.001)
Slovenian: NP 5,35 (0,026)* 11.71 (<0.001)
English: * Defined as an event consistent with hypoglycaemia where the patient required the assistance of another person to recover, lost consciousness, or experienced a seizure (regardless of whether biochemical documentation of a low glucose value was obtained).
Slovenian: * Opredeljeno kot dogodek, ki se sklada s hipoglikemijo, pri katerem je bolnik za razrešitev potreboval pomoč druge osebe, je izgubil zavest ali je imel konvulzije (ne glede na to, ali je bila nizka vrednost glukoze biokemično dokumentirana).
English: These results indicate that the main route of elimination of drug related material was renal.
Slovenian: Ti rezultati kažejo, da je glavna pot izločanja z zdravilom povezanih snovi preko ledvic.
English: • Guidance to the physician for assessing whether the patient is prepared and engaged to perform self-ketone testing before and during therapy.
Slovenian: • Navodila zdravniku za oceno, ali je bolnik pripravljen in zavzet za izvajanje samotestiranja ketonov pred in med zdravljenjem.
English: Study 1 and study 2
Slovenian: Študija 1 in študija 2
English: • if you might be at risk of dehydration (for example, if you are taking medicines that increase urine production [diuretics] or lower blood pressure or if you are over 65 years old).
Slovenian: • če imate tveganje za dehidracijo (na primer če jemljete tablete za odvajanje vode [diuretike] ali tablete za znižanje krvnega tlaka ali če ste stari več kot 65 let).
English: Your doctor may reduce the dose of insulin.
Slovenian: Zdravnik vam lahko zniža odmerek insulina.
English: Common (may affect more than 1 in 100 people)
Slovenian: Pogosti (pojavijo se lahko pri več kot 1 od 100 oseb)
English: - Patients must be able to perform self-management of the day-to-day aspects of their disease including self-monitoring of glucose and ketones.
Slovenian: - Bolniki morajo biti sposobni samostojnega vodenja svoje bolezni iz dneva v dan, vključno s samomerjenjem glukoze in ketonov.
English: The patient may need to take extra rapid-acting insulin and drink water.
Slovenian: Bolnik bo morda moral zaužiti izredno hitrodelujoči insulin in piti vodo.
English: Insulin injections should be given within 2 hours of an unexplained high blood glucose value and sotagliflozin treatment should be interrupted.
Slovenian: Injekcije insulina je treba dati v obdobju 2-eh ur po nepojasnjeni visoki vrednosti glukoze v krvi, ter takoj prekiniti zdravljenje s sotagliflozinom.
English: • Sotagliflozin is not a substitute for insulin (and does not alter insulin-sensitivity).
Slovenian: • Sotagliflozin ni nadomestilo za insulin (in ne spremeni občutljivosti na insulin).
English: • The tablet should be taken before the first meal of the day
Slovenian: • Tableto morate vzeti pred prvim obrokom tisti dan.
English: - Risk factors for diabetic ketoacidosis (DKA) should be assessed and ketone levels should be evaluated as normal.
Slovenian: - Je treba oceniti dejavnike tveganja za diabetično ketoacidozo (DKA) in preveriti, da je koncentracija ketonov normalna.
English: Multiple doses of 800 mg once daily were administrated in healthy volunteers and these doses were well tolerated.
Slovenian: Pri zdravih prostovoljcih so uporabili večkratne odmerke 800 mg enkrat na dan in preiskovanci so te odmerke dobro prenašali.
English: The 52-week completion rates were 84.2%, 86.6%, and 85.3% respectively.
Slovenian: Ustrezni deleži dokončanja po 52 tednih so bili 84,2 %, 86,6 % in 85,3 %.
English: Most of the events were mild or moderate and no serious case was reported.
Slovenian: Večina učinkov je bila blaga ali zmerna in o resnih primerih niso poročali.
English: Like for all diabetic patients it is important to counsel patients on routine preventative footcare.
Slovenian: Tako kot velja za vse osebe s sladkorno boleznijo, je pomembno, da bolnikom svetujete glede redne preventivne oskrbe stopal.
English: Frequency categories are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100),
Slovenian: Kategorije pogostnosti so opredeljene po naslednjem dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do <
English: • Guide for Health Care Professionals including a prescriber's checklist
Slovenian: • Vodnika za zdravstvene delavce, vključno s kontrolnim seznamom za zdravnike, ki predpisujejo zdravilo
English: However, patients should be alerted to the risk of hypoglycaemia as sotagliflozin is used in combination with insulin.
Slovenian: Vendar pa je bolnike treba opozoriti na tveganje za hipoglikemijo, ker se sotagliflozin uporablja v kombinaciji z insulinom.
English: If you are using an insulin pump, monitor your ketones levels three to four hours after changing pump materials.
Slovenian: Če uporabljate insulinsko črpalko, si koncentracijo ketonov kontrolirajte tri do štiri ure po menjavi materialov črpalke.
English: • rifampicin (an antibiotic used to treat tuberculosis and some other infections).
Slovenian: • rifampicin (antibiotik, ki se uporablja za zdravljenje tuberkuloze in nekaterih drugih okužb).
English: If you have any of these symptoms, or if you are in a situation that could increase your risk for DKA, you must check your ketones, either in the blood or in the urine.
Slovenian: Če imate katerega od teh simptomov, ali ste v okoliščinah, ki bi lahko povečale tveganje za DKA, morate kontrolirati ketone v krvi ali urinu.
English: • passing more urine than usual or needing to pass it more often
Slovenian: • odvajanje več urina kot po navadi, ali potreba po pogostejšem odvajanju urina.
English: Sotagliflozin has no or negligible influence on the ability to drive and use machines.
Slovenian: Sotagliflozin nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: What you need to know before you take Zynquista 3.
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Zynquista 3.
English: Available toxicological data in animals have shown excretion of sotagliflozin into milk.
Slovenian: Razpoložljivi toksikološki podatki pri živalih so pokazali izločanje sotagliflozina v mleko.
English: Sanofi Winthrop Industrie 1, rue de la Vierge Ambarès et Lagrave F - 33565 Carbon Blanc France
Slovenian: Sanofi Winthrop Industrie 1, rue de la Vierge Ambarès et Lagrave F - 33565 Carbon Blanc Francija
English: Please carry this card with you at all times and show it to any healthcare professional (HCP) consulted in order to inform them about your current treatment with ZYNQUISTA.
Slovenian: To kartico imejte vedno pri sebi in jo pokažite vsakemu zdravstvenemu delavcu, s katerim se posvetujete, da bo seznanjen z vašim trenutnim zdravljenjem z zdravilom Zynquista.
English: Together these actions help to lower the increased amount of glucose in the blood that occurs in patients with diabetes.
Slovenian: Skupaj ti mehanizmi delovanja pripomorejo k znižanju zvišane koncentracije glukoze v krvi, ki je prisotna pri osebah s sladkorno boleznijo.
English: The educational materials are aimed at providing guidance on how to manage risk of diabetic ketoacidosis (DKA) in patients with type 1 diabetes.
Slovenian: Izobraževalna gradiva so namenjena zagotavljanju smernic za obvladovanje tveganja diabetične ketoacidoze (DKA) pri bolnikih s sladkorno boleznijo tipa 1.
English: Exposure was approximately 5 times (males) and 11 times (females) the clinical exposure at the Maximum Recommended Human Dose (MRHD) and caused reversible renal tubular dilation.
Slovenian: Izpostavljenosti je bila približno 5-krat (samci) in 11-krat (samice) tolikšna kot je klinična izpostavljenost med uporabo največjega priporočenega odmerka za človeka (MRHD) in je povzročila reverzibilno razširitev ledvičnih tubulov.
English: These symptoms could be a sign of a rare but serious or even life-threatening infection, called necrotizing fasciitis of the perineum or Fournier's gangrene which destroys the tissue under the skin.
Slovenian: Ti simptomi so lahko znak redke, toda resne in celo smrtno nevarne okužbe, ki jo imenujemo nekrotizirajoči fasciitis presredka ali Fournierjeva gangrena in uniči podkožno tkivo.
English: The Patient Alert Card is also provided in the product packaging.
Slovenian: Opozorilna kartica za bolnika je priložena tudi v pakiranju zdravila.
English: Do not drive or use any tools or machines, if you feel dizzy during diabetes treatment.
Slovenian: Ne upravljajte vozil in strojev, če med zdravljenjem sladkorne bolezni občutite omotico.
English: Non-interventional PASS: In order to estimate the incidence of DKA in T1DM sotagliflozin treated patients to assess the effectiveness of the risk minimisation measures implemented in Europe, the MAH should conduct and submit the results from an observational cohort study using existing data sources in European countries where sotagliflozin will be launched for T1DM.
Slovenian: Neintervencijska postavtorizacijska študija o varnosti: Da bi ocenil pojavljanje DKA pri bolnikih, zdravljenih s sotagliflozinom T1DM z namenom ocene učinkovitost ukrepov za zmanjšanje tveganja, ki se izvajajo v Evropi, mora imetnik dovoljenja za promet z zdravilom izvesti in predložiti rezultate opazovalne kohortne študije z uporabo obstoječih podatkovnih virov v evropskih državah, kjer se bo sotagliflozin začel uporabljati za T1DM.
English: What Zynquista is and what it is used for 2.
Slovenian: Kaj je zdravilo Zynquista in za kaj ga uporabljamo 2.
English: This atypical presentation of DKA can delay diagnosis and treatment.
Slovenian: Ta neznačilna klinična slika DKA lahko povzroči zamudo pri diagnozi in zdravljenju.
English: Patients taking sotagliflozin with concomitant digoxin should be monitored appropriately.
Slovenian: Bolnike, ki jemljejo sotagliflozin sočasno z digoksinom, je treba ustrezno kontrolirati.
English: Sanofi Winthrop Industrie 1 rue de la Vierge Ambares et Lagrave 33565 Carbon Blanc Cedex France
Slovenian: Sanofi Winthrop Industrie 1 rue de la Vierge Ambares et Lagrave 33565 Carbon Blanc Cedex Francihja
English: Two cases (2 cases of cystitis) were serious; both occurred in male subjects in the sotagliflozin 400 mg group.
Slovenian: Dva primera (2 primera cistitisa) sta bila resna; oba sta se pojavila med moškimi in v skupini s 400 mg sotagliflozina.
English: In healthy volunteers, mean apparent total body clearance (CL/F) of sotagliflozin ranged from 261 to 374 L/hr.
Slovenian: Pri zdravih prostovoljcih je bil navidezni celotni telesni očistek (CL/F) sotagliflozina od 261 do 374 l/uro.
English: • digoxin or digitoxin (medicines used for heart problems).
Slovenian: • digoksin ali digitoksin (zdravili, ki se uporabljata za težave s srcem).
English: Sotagliflozin should be taken once daily before the first meal of the day.
Slovenian: Sotagliflozin je treba jemati enkrat na dan, pred prvim dnevnim obrokom.
English: Share it with all of your doctors, nurses or pharmacists when you need any treatment.
Slovenian: Pokažite jo zdravnikom, medicinski sestri ali farmacevtu, kadar koli potrebujete kakšno zdravljenje.
English: Main results regarding insulin dose are presented in Table 6.
Slovenian: Glavni rezultati glede odmerka insulina so prikazani v preglednici 6.
English: In order to avoid hypoglycaemia with the first dose of sotagliflozin a 20% reduction in the first mealtime bolus insulin may be considered.
Slovenian: Da bi preprečili hipoglikemijo po prvem odmerku sotagliflozina, je treba razmisliti o 20-odstotnem zmanjšanju prvega odmerka bolusnega insulina ob obroku.
English: The recommended actions are listed in Table 1 (see section 4.2).
Slovenian: Priporočeni ukrepi so navedeni v preglednici 1 (glejte poglavje 4.2).
English: - who are able to monitor ketone levels and are educated in when it is most appropriate to do so.
Slovenian: - ki so usposobljeni kontrolirati koncentracijo ketonov in so dobro poučeni, kdaj je najprimerneje opraviti meritev.
English: It is unknown whether this constitutes a class effect.
Slovenian: Ni znano, ali gre za učinek te skupine zdravil.
English: This atypical presentation of DKA (i.e. normal or slightly elevated blood glucose levels) can delay diagnosis and treatment.
Slovenian: Takšna netipična klinična slika DKA (tj. normalna ali nekoliko zvišana koncentracija glukoze v krvi) lahko povzroči zapoznelo diagnosticiranje in zdravljenje.
English: However, the differences in exposure were not considered clinically meaningful and therefore no dose adjustment is required based on weight.
Slovenian: Vendar te razlike ne veljajo za klinično pomembne, zato prilagoditev odmerka glede na telesno maso ni potrebna.
English: Measurement of blood ketone levels is preferred over urine.
Slovenian: Meritve koncentracije ketonov v krvi imajo prednost pred meritvami v urinu.
English: It is important that you also continue with your diet and exercise plan and insulin treatment as agreed with your doctor, pharmacist or nurse.
Slovenian: Pomembno je, da še naprej upoštevate dieto, vzdržujete telesno dejavnost in nadaljujete zdravljenje z insulinom, kot ste se dogovorili z zdravnikom, farmacevtom ali medicinsko sestro.
English: • ZYNQUISTA increases the risk of DKA.
Slovenian: • Zdravilo Zynquista poveča tveganje za DKA.
English: DKA should be treated as per standard of care.
Slovenian: DKA je treba zdraviti v skladu z običajnim zdravljenjem.
English: • if you had a recent or recurrent history of diabetic ketoacidosis (e.g. 1 episode in the past 3 months or more than 1 episode in the past 6 months)
Slovenian: • če ste diabetično ketoacidozo imeli nedavno ali se vam ponavlja (npr. 1 pojav v preteklih 3 mesecih ali več kot 1 pojav v preteklih 6 mesecih),
English: • Zynquista should be taken once daily by mouth.
Slovenian: • Zdravilo Zynquista je treba zaužiti (peroralno jemanje) enkrat na dan.
English: In study 2, a total of 782 patients entered the study.
Slovenian: V klinično preskušanje 2 je vstopilo skupno 782 bolnikov.
English: This decrease in exposure to sotagliflozin may decrease efficacy.
Slovenian: Zmanjšanje izpostavljenosti sotagliflozinu lahko zmanjša njegovo učinkovitost.
English: Patient name:-------------------------Date ZYNQUISTA first prescribed:--------------------------Center name:--------------------------Treating HCP name:-----------------Treating HCP contact number:---------------------
Slovenian: Ime lečečega zdravnika: -----------------Kontaktna številka lečečega zdravnika: ---------------------
English: For all patients, it is recommended that ketones should be measured with changes to the normal routine, including reduced carbohydrate intake, intercurrent illness, reductions in total daily insulin dosing, physical activity and stress.
Slovenian: Za vse bolnike je merjenje ketonov priporočljivo v primeru sprememb običajne rutine, vključno z zmanjšanjem vnosa ogljikovih hidratov, trenutnim bolezenskim stanjem, zmanjšanjem celotnega dnevnega odmerka insulina, telesno dejavnostjo in stresom.
English: HbA1c < 7.0% at week 24, n (%)
Slovenian: HbA1c < 7,0 % po 24 tednih, n (%)
English: Other medicines and Zynquista
Slovenian: Druga zdravila in zdravilo Zynquista
English: The predominant metabolite detected in urine was M19, representing a mean of 33% of the administered radioactive dose.
Slovenian: Prevladujoči presnovek v urinu je bil M19, ki predstavlja povprečno 33 % uporabljenega radioaktivnega odmerka.