FrancophonIA/ELRC3.0 huggingface dataset:
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred jemanjem tega zdravila posvetujte z zdravnikom.
English: No studies on the effects of Ranexa on the ability to drive and use machines have been performed.
Slovenian: Študij o vplivu zdravila Ranexa na sposobnost vožnje in upravljanja s stroji niso izvedli.
English: Rare: throat tightness.
Slovenian: Redki: stiskanje v grlu.
English: Ranexa exposure increases more than in proportion to dose.
Slovenian: Izpostavljenost zdravilu Ranexa se poveča bolj kot glede na odmerek.
English: If a patient experiences treatment-related adverse events (e.g. dizziness, nausea, or vomiting), downtitration of Ranexa to 500 mg or 375 mg twice daily may be required.
Slovenian: Če se pri bolniku pojavijo neželeni učinki, povezani z zdravljenjem (npr. omotica, navzea ali bruhanje), bo morda treba odmerek zdravila Ranexa titrirati nazaj na 500 mg ali 375 mg dvakrat na dan.
English: Therefore, digoxin levels should be monitored following initiation and termination of Ranexa therapy.
Slovenian: Zato je treba po začetku in koncu zdravljenja z zdravilom Ranexa ravni digoksina nadzorovati.
English: Given the dose-dependent side effects and similar efficacy at 750 and 1000 mg twice daily, a maximum dose of 750 mg twice daily is recommended.
Slovenian: Glede na neželene učinke, odvisne od odmerka, in podobno učinkovitost pri odmerkih 750 in 1000 mg dvakrat na dan se priporoča največji odmerek 750 mg dvakrat na dan.
English: This reduction in cellular calcium overload is expected to improve myocardial relaxation and thereby decrease left ventricular diastolic stiffness.
Slovenian: Pričakovati je, da bo zmanjšanje preobremenitve s kalcijem izboljšalo relaksacijo miokarda in posledično zmanjšalo diastolično otrdelost levega ventrikla.
English: If the CYP2D6 status of the patient has been determined (e.g. by genotyping) or is previously known to be EM, Ranexa can be used with caution in these patients when they have a combination of several of the above risk factors.
Slovenian: Če je status CYP2D6 pri bolniku določen (npr. z določanjem genotipa) ali pa je znano, da gre za BMP, se zdravilo Ranexa pri teh bolnikih lahko uporablja, kadar imajo kombinacijo več zgoraj navedenih dejavnikov tveganja, vendar je potrebna previdnost.
English: METHOD AND ROUTE(S) OF ADMINISTRATION For oral use.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Za peroralno uporabo.
English: Available pharmacodynamic/toxicological data in rats have shown excretion of ranolazine in milk (for details see Section 5.3).
Slovenian: Farmakodinamični/toksikološki podaki, ki so na voljo so pokazali, da se ranolazin izloča v mleko (za podrobnosti glejte poglavje 5.3).
English: Fertility: In animals, reproduction studies indicated no adverse effects on fertility (see section 5.3).
Slovenian: Plodnost: Študije razmnoževanja na živalih niso pokazale neželenih učinkov na plodnost (glejte poglavje 5.3).
English: The terminal half-life at steady state after oral administration of ranolazine is about 7 hours, due to the absorption rate-limited elimination.
Slovenian: Končni razpolovni čas v stanju dinamičnega ravnovesja po peroralnem odmerjanju ranolazina je približno 7 ur zaradi izločanja, omejenega s hitrostjo absorpcije.
English: CHF: CHF NYHA Class III and IV were estimated to have about 1.3-fold higher plasma concentrations.
Slovenian: CHF: Ocenili so, da so pri bolnikih s CHF III. in IV. razreda po razvrstitvi NYHA koncentracije v plazmi približno 1,3-krat večje.
English: Absorption: The mean absolute bioavailability of ranolazine after oral administration of immediaterelease ranolazine tablets ranged from 35−50%, with large inter-individual variability.
Slovenian: Absorpcija: Povprečna absolutna biološka uporabnost ranolazina po peroralni uporabi tablet ranolazina s takojšnjim sproščanjem je bila 35- do 50-odstotna, z velikimi razlikami med posamezniki.
English: Ranexa is supplied in cartons containing 30, 60, or 100 tablets in blister strips or 60 tablets in plastic bottles.
Slovenian: Zdravilo Ranexa je na voljo v škatlah s po 30, 60 ali 100 tabletami v pretisnih omotih ali 60 tabletami v plastenkah.
English: After oral administration of Ranexa, peak plasma concentrations (Cmax) are typically observed between 2 and 6 hours.
Slovenian: Po peroralni uporabi zdravila Ranexa so največje koncentracije v plazmi (Cmax) ponavadi opažene po 2 do 6 urah.
English: Your doctor may lower your dose or stop treatment with Ranexa.
Slovenian: Zdravnik vam bo morda zmanjšal odmerek ali prekinil zdravljenje z zdravilom Ranexa.
English: These medicines may cause an increase in the number of side effects, such as dizziness, nausea, or vomiting, which are possible side effects of Ranexa (see section 4).
Slovenian: Ta zdravila lahko povečajo število neželenih učinkov, kot so omotica, slabost ali bruhanje, ki so mogoči neželeni učinki zdravila Ranexa (glejte poglavje 4).
English: In male and female rats, oral administration of ranolazine that produced exposures (AUC) 3.6-fold or 6.6-fold higher than expected in humans, respectively, had no effect on fertility.
Slovenian: Pri samcih in samicah podgan, kjer je po peroralnem odmerku ranolazina bila izpostavljenost zdravilu (AUC) 3,6 do 6,6 krat večja kot je pričakovana pri ljudeh, ni bilo učinka na plodnost.
English: The above precautions are based on the risk in a CYP2D6 PM patient, and are needed when the CYP2D6 status is unknown.
Slovenian: Zgoraj navedeni previdnosti ukrepi temeljijo na tveganju pri bolnikih, pri katerih je aktivnost encima CYP2D6 slaba, potrebni pa so tudi, kadar status CYP2D6 ni znan.
English: Ranexa should not be used during breast-feeding.
Slovenian: Zdravilo Ranexa se med dojenjem ne sme uporabljati.
English: LIST OF EXCIPIENTS Contains colouring agent E102 and lactose; see package leaflet for further information.
Slovenian: SEZNAM POMOŽNIH SNOVI Vsebuje barvilo E102 in laktozo; za dodatne informacije glejte navodilo za uporabo.
English: QT prolongation: Ranolazine blocks IKr and prolongs the QTc interval in a dose-related manner.
Slovenian: Podaljšanje intervala QT: Ranolazin blokira IKr in podaljša QTc interval v odvisnosti od odmerka.
English: Rare: elevated levels of hepatic enzyme.
Slovenian: Redki: zvišane ravni jetrnih encimov.
English: Effects of ranolazine on other medicinal products
Slovenian: Učinek ranolazina na druga zdravila
English: These doses are equivalent to 0.1 and 0.8 times, respectively, the maximum recommended human dose of 2 grams on a mg/m basis, and represent the maximum tolerated doses in these species.
Slovenian: Ti odmerki so bili enakovredni 0,1-kratnemu oziroma 0,8-kratnemu največjemu priporočenemu odmerku pri človeku, ki je 2 g, izražen v mg/m2; pomenijo pa največje odmerke, ki jih te živalske vrste prenašajo.
English: Embryofetal toxicity studies were conducted in rats and rabbits: no effect were noted in rabbit fetuses when mothers were exposed at levels (AUC) of plasma ranolazine similar to expected human levels.
Slovenian: Študije embriofetalne toksičnosti so bile izvedene na podganah in kuncih: na zarodkih kuncev ni bilo opaženih učinkov po izpostavljenosti (AUC) s plazemskimi vrednostmi ranolazina na brejih kuncih v podobnih ravneh kot je predvidena za človeka.
English: A small proportion of non-Caucasians was included in the controlled clinical studies; therefore, no conclusions can be drawn regarding the effect and safety in non-Caucasians.
Slovenian: V nadzorovanih kliničnih študijah je bil odstotek nebelcev majhen, zato o učinkovitosti in varnosti zdravila pri nebelcih ni mogoče sklepati.
English: CYP3A4 inducers: Rifampicin (600 mg once daily) decreases ranolazine steady-state concentrations by approximately 95%.
Slovenian: Spodbujevalci encima CYP3A4: Rifampicin (600 mg enkrat na dan) zniža koncentracijo ranolazina v stanju dinamičnega ravnovesja za približno 95%.
English: If you accidentally take too many Ranexa tablets or take a higher dose than recommended by your doctor, it is important that you tell your doctor at once.
Slovenian: Če ste vzeli večji odmerek zdravila Ranexa, kot bi smeli Če ste pomotoma vzeli preveč tablet zdravila Ranexa ali če ste vzeli večji odmerek, kot vam je predpisal zdravnik, morate takoj obvestiti zdravnika.
English: Renal impairment: Renal function decreases with age and it is therefore important to check renal function at regular intervals during treatment with ranolazine (see sections 4.2, 4.3, 4.8, and 5.2).
Slovenian: Ledvična okvara: Delovanje ledvic se s starostjo slabša, zato je med zdravljenjem z ranolazinom pomembno v rednih intervalih preverjati ledvično funkcijo (glejte poglavja 4.2, 4.3, 4.8 in 5.2).
English: 1, Avenue de la Gare, L-1611 Luxembourg Luxembourg
Slovenian: 1, Avenue de la Gare, L-1611 Luxembourg Luksemburg
English: Ranolazine, via its action to decrease the late sodium current, is considered to reduce these intracellular ionic imbalances during ischaemia.
Slovenian: Menijo, da ranolazin, zaradi zmanjšanja poznega toka natrija, zmanjša znotrajcelično neravnovesje ionov med ishemijo.
English: What you need to know before you take RANEXA
Slovenian: Kaj morate vedeti, preden boste vzeli zdraVILO RANEXA
English: Metabolism and nutrition disorders Uncommon: anorexia, decreased appetite, dehydration.
Slovenian: Presnovne in prehranske motnje Občasni: anoreksija, zmanjšan apetit, dehidracija.
English: The starting dose for adults is one 375 mg tablet twice a day.
Slovenian: Začetni odmerek za odrasle je ena 375-miligramska tableta dvakrat na dan.
English: In this study, there was a higher reporting rate for congestive heart failure in the ranolazine group (2.2% vs 1.0% in placebo).
Slovenian: V tej študiji je bil večji delež poročanih primerov srčnega popuščanja v ranolazin skupini (2,2% v primerjavi s placebom 1,0%).
English: Effects of other medicinal products on ranolazine
Slovenian: Učinek drugih zdravil na ranolazin
English: The AUC of one pharmacologically active ranolazine metabolite was 5-fold increased in patients with severe renal impairment.
Slovenian: Vrednost AUC enega farmakološko aktivnega presnovka ranolazina se je pri bolnikih s hudo ledvično okvaro povečala za 5-krat.
English: Rare: acute renal failure, urinary retention.
Slovenian: Redki: akutna odpoved ledvic, retencija urina.
English: Rare: impaired hearing.
Slovenian: Redki: poslabšan sluh.
English: Adverse reactions not observed in clinical studies, but seen in animals at levels similar to clinical exposure, were as follows: Ranolazine was associated with convulsions and increased mortality in rats and dogs at plasma concentrations approximately 3-fold higher than at the proposed maximum clinical dose.
Slovenian: Neželene reakcije, ki jih v kliničnih študijah niso opazili, vendar so jih opazili v študijah na živalih pri koncentracijah, ki so bile podobne kliničnim koncentracijam, so bile: ranolazin je bil pri koncentracijah v plazmi, ki so bile približno 3-krat večje od predlaganih največjih kliničnih odmerkov, povezan s konvulzijami in povečano umrljivostjo pri podganah in psih.
English: Clearance of ranolazine is dose-dependent, decreasing with increased dose.
Slovenian: Očistek ranolazina je odvisen od odmerka in se s povečanjem odmerka manjša.
English: Elimination: Ranolazine is eliminated primarily by metabolism.
Slovenian: Izločanje: Ranolazin se izloča predvsem s presnovo.
English: Rare: pancreatitis, erosive duodenitis, oral hypoaesthesia.
Slovenian: Redki: pankreatitis, erozijski duodenitis, oralna hipestezija.
English: No proarrhythmic effects were observed in 3,162 patients treated with Ranexa based on 7-day Holter monitoring in the MERLIN-TIMI 36 study.
Slovenian: V študiji MERLIN-TIMI 36 niso opazili proaritmičnih učinkov pri 3162 bolnikih, ki so prejemali zdravilo Ranexa, na podlagi 7-dnevnega Holterjevega spremljanja.
English: Atorvastatin: Ranexa 1000 mg twice daily increased Cmax and AUC of atorvastatin 80 mg once daily by 1.4- and 1.3 -fold, respectively and changed the Cmax and AUC of atorvastatin metabolites less than 35%.
Slovenian: Atorvastatin: Jemanje zdravila Ranexa 1000 mg dvakrat na dan je povečalo Cmax in AUC atorvastatina 80 mg vzetega enkrat na dan za 1,4- oziroma 1,3- krat ter spremenilo Cmax in AUC metabolitov atorvastatina za manj kot 35%.
English: Improvement of exercise duration was statistically significant compared to placebo for all three doses of ranolazine from 24 seconds at 500 mg twice daily to 46 seconds at 1500 mg twice daily, showing a dose-related response.
Slovenian: V primerjavi s placebom je bilo izboljšanje trajanja telesne vadbe statistično pomembno pri vseh treh odmerkih ranolazina, od 24 sekund pri 500 mg dvakrat na dan do 46 sekund pri 1500 mg dvakrat na dan, kar kaže na odziv, povezan z odmerkom.
English: Not all pack-sizes may be marketed.
Slovenian: Na trgu ni vseh navedenih pakiranj.
English: Each tablet contains 375 mg, 500 mg, or 750 mg ranolazine.
Slovenian: Ena tableta vsebuje 375 mg, 500 mg ali 750 mg ranolazina.
English: Available data suggest that ranolazine is a mild inhibitor of CYP2D6.
Slovenian: Razpoložljivi podatki kažejo, da je ranolazin šibek zaviralec encima CYP2D6.
English: Ranexa is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled or intolerant to first-line antianginal therapies (such as beta-blockers and/or calcium antagonists).
Slovenian: Zdravilo Ranexa je indicirano kot dodatno zdravljenje za simptomatsko zdravljenje odraslih bolnikov s stabilno angino pektoris, pri katerih bolezen ni ustrezno nadzorovana ali ki ne prenašajo prve izbire zdravljenja proti angini (kot so beta-blokatorji in/ali antagonisti kalcija).
English: In subjects with severe renal impairment (creatinine clearance 10-30 ml/min), a 1.3- to 1.8-fold increase in ranolazine exposure was estimated.
Slovenian: Pri osebah s hudo ledvično okvaro (kreatininski očistek 10-30 ml/min) so ocenili, da je povečanje izpostavljenosti ranolazinu 1,3- do 1,8krat večje.
English: Post-natal mortality of pups was not recorded when the exposure of nursing mothers was 1.3 fold higher than in expected humans, whereas at 3-fold higher exposure post-natal mortality was recorded, concomitant with evidence of milk excretion of ranolazine in rats.
Slovenian: Smrtnost po skotitvi mladičev pri izpostavljenosti brejih podgan nad 1,3 kratno vrednostjo zdravila kot je predvidena za človeka, ni bila zabeležena, medtem ko je bila pri 3-krat večji izpostavljenosti, zabeležena smrtnost po skotitvi, sočasno z dokazi izločanja ranolazina v mleku podgan.
English: Your doctor may lower your dose or, if this is not sufficient, stop treatment with Ranexa.
Slovenian: Zdravnik vam bo morda zmanjšal odmerek, ali če to ne bo odpravilo težav, prekinil zdravljenje z zdravilom Ranexa.
English: Tell your doctor or pharmacist before you take Ranexa if you use: - certain medicines to treat a bacterial infection (erythromycin), or a fungal infection (fluconazole), a medicine used to prevent rejection of a transplanted organ (ciclosporin), or if you are taking some heart tablets such as diltiazem or verapamil.
Slovenian: Povejte zdravniku ali farmacevtu, preden boste vzeli zdravilo Ranexa, če uporabljate: - nekatera zdravila za zdravljenje bakterijskih okužb (eritromicin) ali glivičnih okužb (flukonazol), zdravila za preprečevanje zavračanja presajenega organa (ciklosporin) ali če jemljete tablete za srce, kot na primer diltiazem ali verapamil.
English: In vitro studies using human liver microsomes indicate that ranolazine is metabolised primarily by CYP3A4, but also by CYP2D6.
Slovenian: Študije in vitro na mikrosomih človeških jeter so pokazale, da ranolazin presnavlja predvsem encim CYP3A4, vendar tudi encim CYP2D6.
English: The incidence of adverse events was higher in the elderly (see section 4.8).
Slovenian: Pogostnost neželenih učinkov je bila pri starejših bolnikih večja (glejte poglavje 4.8).
English: The influence of dialysis on the pharmacokinetics of ranolazine has not been evaluated.
Slovenian: Učinka dialize na farmakokinetiko ranolazina niso ocenjevali.
English: This is also recommended for other CYP3A4 substrates with a narrow therapeutic range (e.g., ciclosporin, sirolimus, everolimus).
Slovenian: To je priporočljivo tudi za ostale substrate CYP3A4 z ozkim terapevtskim oknom (npr. ciklosporin, sirolimus, everolimus).
English: It is important that you tell your doctor if you get side effects such as dizziness or feeling or being sick.
Slovenian: Pomembno je, da zdravnika obvestite, če se pojavijo neželeni učinki, kot so omotica, siljenje na bruhanje ali bruhanje.
English: Also, transient ischemic attack occurred more frequently in patients treated with ranolazine 1000 mg twice daily compared with placebo (1.0% vs 0.2%, respectively); however, the incidence of stroke was similar between treatment groups (ranolazine 1.7% vs placebo 1.5%).
Slovenian: Tudi prehodni ishemični napadi so se pojavili bolj pogosto pri bolnikih zdravljenih z ranolazinom 1000 mg dvakrat na dan kot s placebom (1,0% oziroma 0,2%); vendar je bila pojavnost možganske kapi podobna med zdravljenima skupinama (ranolazin 1,7% proti placebo 1,5%).
English: Ranolazine may have some antianginal effects by inhibition of the late sodium current in cardiac cells.
Slovenian: Nekateri antianginozni učinki ranolazina so lahko posledica zaviranja poznega toka natrija v srčnih celicah.
English: The results showed that exercise duration was 31 seconds longer in ranolazine patients versus placebo patients (p = 0.002).
Slovenian: Rezultat je pokazal, da je bilo trajanje telesne vadbe pri bolnikih, ki so prejemali ranolazin, 31 sekund daljše kot pri bolnikih, ki so prejemali placebo (p = 0,002).
English: 750 mg tablet: glycerol triacetate, lactose monohydrate, Blue #1/Brilliant Blue FCF Aluminium Lake
Slovenian: 750-miligramska tableta: gliceroltriacetat, laktozo monohidrat, modro aluminijevo barvilo FCF št.1
English: No significant difference occurred in the composite primary endpoint (time to first occurrence of ischaemia-driven revascularisation or ischaemia-driven hospitalisation without revascularisation) in the ranolazine group (26.2%) versus the placebo group (28.3%), hazard ratio 0.95, 95% CI 0.82-1.10 p= 0.48.
Slovenian: Ni bilo pomembno značilnih razlik v primarnem sestavljenem opazovanem dogodku (čas do prvega pojava revaskularizacije zaradi ishemije ali hospitalizacije zaradi ishemije brez revaskularizacije) v skupini, ki je prejemala ranolazin (26,2%) glede na placebo skupino (28,3%), razmerje ogroženosti 0,95, 95% CI 0,82-1,10 p= 0,48.
English: This reduces intracellular sodium accumulation and consequently decreases intracellular calcium overload.
Slovenian: To zmanjša znotrajcelično kopičenje natrija in posledično zmanjša znotrajcelično preobremenitev s kalcijem.
English: Do not chew.
Slovenian: Tablet ne žvečite.
English: Ranolazine is a moderate to potent inhibitor of P-gp and a mild inhibitor of CYP3A4, and may increase plasma concentrations of P-gp or CYP3A4 substrates.
Slovenian: Ranolazin je zmeren do močan zaviralec P-gp in blag zaviralec encima CYP3A4 ter lahko zviša plazemske koncentracije substratov P-gp ali CYP3A4.
English: CYP2D6 inhibitors: Ranolazine is partially metabolised by CYP2D6; therefore, inhibitors of this enzyme may increase plasma concentrations of ranolazine.
Slovenian: Zaviralci encima CYP2D6: Encim CYP2D6 delno presnavlja ranolazin, zato njegovo zaviranje lahko poveča koncentracijo ranolazina v plazmi.
English: Simvastatin: Simvastatin metabolism and clearance are highly dependent on CYP3A4.
Slovenian: Simvastatin: Presnova in očistek simvastatina sta v veliki meri odvisna od encima CYP3A4.
English: Therefore, caution should be observed when treating patients with a history of congenital or a family history of long QT syndrome, in patients with known acquired QT interval prolongation, and in patients treated with drugs affecting the QTc interval (see section 4.5 also).
Slovenian: Pri zdravljenju bolnikov s prirojenim sindromom ali sindromom podaljšanega intervala QT v družinski anamnezi, pri bolnikih z znanim pridobljenim podaljšanjem intervala QT in pri bolnikih, zdravljenih z zdravili, ki vplivajo na dolžino intervala QTc, je zato potrebna previdnost (glejte tudi poglavje 4.5).
English: An increased incidence of adverse events was seen among ranolazine treated patients in the RIVERPCI trial (see section 5.1) where patients with incomplete revascularization post-PCI were given ranolazine up to 1000 mg twice daily or placebo for approximately 70 weeks.
Slovenian: Povečana pojavnost neželenih učinkov je bila opažena med bolniki, ki so se zdravili z ranolazinom v RIVER-PCI študiji (glejte poglavje 5.1), kjer so bolniki z nepopolno revaskularizacijo po PKI prejemali ranolazin do 1000 mg dvakrat na dan ali placebo približno 70 tednov.
English: In healthy young adults, ranolazine accounts for approximately 13% of the radioactivity in plasma following a single oral 500 mg dose of [
Slovenian: Pri zdravih mladih prostovoljcih ranolazin predstavlja približno 13% radioaktivnosti v plazmi po enkratnem 500miligramskem odmerku [14C]-ranolazina.
English: The potential for dose-related adverse events (e.g. nausea, dizziness) may also increase with increased plasma concentrations.
Slovenian: Možnost neželenih učinkov, odvisnih od odmerka (npr. navzeje in omotice), se tudi lahko zveča z zvišanjem koncentracije v plazmi.
English: Adults: The recommended initial dose of Ranexa is 375 mg twice daily.
Slovenian: Odrasli: Priporočeni začetni odmerek zdravila Ranexa je 375 mg dvakrat na dan.
English: Concomitant treatment with ketoconazole 200 mg twice daily increased the AUC of ranolazine by 3.0- to 3.9-fold during ranolazine treatment.
Slovenian: Sočasna uporaba 200 mg ketokonazola dvakrat na dan med zdravljenjem z ranolazinom je povečala vrednost AUC ranolazina za 3,0- do 3,9-krat.
English: This medicine contains less than 1 mmol sodium (23 mg) per prolonged-release tablet, that is to say essentially ‘sodium-free'.
Slovenian: To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na 1 tableto s podaljšanim sproščanjem, kar v bistvu pomeni 'brez natrija'.
English: The corresponding difference at the 1000 mg twice-daily dose was 25%.
Slovenian: Razlika pri odmerku 1000 mg dvakrat na dan je bila 25%.
English: At the dose level 500 mg twice daily, co-administration of a potent inhibitor of CYP2D6 could result in an increase in ranolazine AUC of about 62%.
Slovenian: Pri odmerku 500 mg dvakrat na dan lahko sočasna uporaba močnega zaviralca encima CYP2D6 poveča vrednost AUC ranolazina za približno 62%.
English: However, men and women had similar reductions in frequency of angina attacks and nitroglycerin consumption.
Slovenian: Vendar je bilo zmanjšanje pogostnosti napadov angine in porabe nitroglicerina pri moških in ženskah podobno.
English: Down-titration of Ranexa may be required (see sections 4.2 and 4.4).
Slovenian: Morda bo potrebno zmanjšanje odmerka s titracijo (glejte poglavji 4.2 in 4.4).
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS PVC/PVDC/Aluminium blisters
Slovenian: Pretisni omoti iz PVC/PVDC/aluminija
English: The elimination half-life is about 2−3 hours after intravenous administration.
Slovenian: Po intravenskem odmerjanju je razpolovni čas izločanja približno 2-3 ure.
English: Biotransformation: Ranolazine undergoes rapid and extensive metabolism.
Slovenian: Biološka transformacija: Ranolazin se presnavlja hitro in v veliki meri.
English: (E133) and Yellow #5/Tartrazine Aluminium Lake (E102)
Slovenian: (E133) in rumeno aluminijevo barvilo tartrazin št. 5 (E102)
English: Inhibitors of CYP3A4 increase plasma concentrations of ranolazine.
Slovenian: Zaviralci encima CYP3A4 zvišajo koncentracijo ranolazina v plazmi.
English: What Ranexa looks like and contents of the pack Ranexa prolonged-release tablets are oval shaped tablets.
Slovenian: Izgled zdravila Ranexa in vsebina pakiranja Zdravilo Ranexa tablete s podaljšanim sproščanjem so ovalne tablete.