FrancophonIA/ELRC3.0 huggingface dataset:
English: Severe symptoms require prompt emergency treatment.
Croatian: Ako se pojave teški simptomi, potrebno je hitno liječenje.
English: Younger children in general required higher median doses (6-12 years: 43.9 IU/kg; 2-5 years: 52.6 IU/kg).
Croatian: Za mlađu djecu općenito su bili potrebni veći medijani doze (6-12 godina: 43,9 IU/kg; 2 - 5 godina: 52,6 IU/kg).
English: The amount to be administered and the frequency of administration should always be oriented to the clinical effectiveness in the individual case.
Croatian: Količina koja se primjenjuje i učestalost primjene moraju uvijek biti individualno prilagođeni kliničkoj učinkovitosti u pojedinom slučaju.
English: From a microbiological point of view, the product should be used immediately after reconstitution.
Croatian: S mikrobiološkog stajališta, lijek je potrebno primijeniti odmah nakon rekonstitucije.
English: T1/2 (hr)
Croatian: T1/2 (h)
English: Pharmacotherapeutic group: Antihaemorrhagics: blood coagulation factor VIII, ATC code: B02BD02.
Croatian: Farmakoterapijska skupina: Antihemoragici: faktor zgrušavanja krvi VIII, ATK oznaka: B02BD02.
English: Paediatric population The listed warnings and precautions apply both to adults and children.
Croatian: Pedijatrijska populacija Navedena upozorenja i mjere opreza odnose se na odrasle i djecu.
English: Your doctor will calculate your dose of Vihuma (in international units = IU) depending on your condition and body weight, and on whether it is used for prevention or treatment of bleeding.
Croatian: Vaš liječnik će izračunati potrebnu dozu lijeka Vihuma (u međunarodnim jedinicama = IU) s obzirom na Vaše stanje i tjelesnu težinu i ovisno o tome koristi li se lijek za sprječavanje ili liječenje krvarenja.
English: Toxicology studies showed that local intravenous administration and systemic exposure were well tolerated in laboratory animals (rats and cynomolgus monkeys).
Croatian: Toksikološka ispitivanja pokazala su dobru podnošljivost lokalne intravenske primjene i sistemske izloženosti kod laboratorijskih životinja (štakora i makaki majmuna).
English: The factor VIII/von Willebrand factor complex consists of two molecules (factor VIII and von Willebrand factor) with different physiological functions.
Croatian: Spoj faktor VIII/von Willebrandov faktor sastoji se od dvije molekule (faktor VIII i von Willebrandov faktor) s različitim fiziološkim funkcijama.
English: For storage at room temperature and storage conditions after reconstitution of the medicinal product, see section 6.3.
Croatian: Za čuvanje na sobnoj temperaturi i uvjete čuvanja nakon rekonstitucije lijeka vidjeti u dijelu 6.3.
English: The mean ± SD annualised bleeding rate was 1.2 ± 3.9 and the mean ± SD dose were 52.2 ± 12.2 IU/kg per injection and 99.7 ± 25.6 IU/kg per week.
Croatian: Srednja vrijednost ± SD anualizirane stope krvarenja bila je 1,2 ± 3,9, a srednja vrijednost ± SD doze bila je 52,2 ± 12,2 IU/kg po injekciji i 99,7 ± 25,6 IU/kg tjedno.
English: There is a rare chance that you may experience an anaphylactic reaction (a severe, sudden allergic reaction) to Vihuma.
Croatian: Postoje mali izgledi da ćete doživjeti anafilaktičku reakciju (teška i iznenadna alergijska reakcija) na
English: Vihuma is for intravenous use.
Croatian: Vihuma je namijenjena za intravensku primjenu.
English: Ex vivo evaluations using a commercial assay kit to quantify T cell response to protein therapeutics indicate a low risk of immunogenicity.
Croatian: Procjene ex vivo uporabom komercijalnog kompleta za ispitivanje radi kvantifikacije odgovora Tstanica na proteinske terapeutike ukazuju na nizak rizik od imunogenosti.
English: Without removing the syringe, gently move or swirl the vial in circles a few times to dissolve the powder.
Croatian: Ne uklanjajući štrcaljku nježno pomaknite ili okrenite bočicu u krug nekoliko puta da biste otopili prašak.
English: If this happens you or your child´s medicines may stop working properly and you or your child may experience persistent bleeding.
Croatian: U tom slučaju, Vaš lijek ili lijek Vašeg djeteta može prestati ispravno djelovati, a kod Vas ili Vašeg djeteta može se javiti krvarenje koje ne prestaje.
English: Do not use this medicine after the expiry date which is stated on the label after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici iza oznake „EXP“.
English: You should be aware of the early signs of allergic reactions as they are listed in section 4 “Allergic reactions”.
Croatian: Morate moći prepoznati rane znakove alergijskih reakcija koji su navedeni u dijelu 4 "Alergijske reakcije".
English: Individualised prophylaxis: Individualised PK-based prophylaxis was evaluated in 66 adult PTPs with severe haemophilia A. Following a 1-3 month standard prophylaxis phase (every other day or 3 times weekly dosing), 44 (67%) patients were switched to a dosing regimen based on their PK assessment, and 40 completed the 6 months of prophylaxis according to the assigned dosing and treatment scheme.
Croatian: Individualizirana profilaksa: Individualizirana profilaksa na temelju farmakokinetike bila je ocijenjena u 66 odraslih prethodno liječenih bolesnika s teškom hemofilijom A. Nakon faze standardne profilakse od 1-3 mjeseca (doziranje svaki drugi dan ili 3 puta tjedno), 44 (67%) bolesnika bilo je prebačeno na režim doziranja temeljen na njihovoj farmakokinetičkoj procjeni, a 40 bolesnika je završilo 6-mjesečnu profilaksu sukladno dodijeljenoj shemi doziranja i liječenja.
English: You might need a higher dose of Vihuma or a different product to control bleedings.
Croatian: Možda će Vam trebati veća doza lijeka Vihuma ili drugi lijek za kontrolu krvarenja.
English: Do not increase the total dose of Vihuma to control your bleeding without consulting your doctor.
Croatian: Nemojte povećavati ukupnu dozu lijeka Vihuma da biste kontrolirali krvarenje prije savjetovanja s liječnikom.
English: Detailed information on this medicine is available on the web site of the European Medicines Agency: http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: Minor surgery including tooth extraction
Croatian: Kirurški zahvati Manji kirurški zahvat uključujući vađenje zuba
English: Inhibitory activity, as measured by the modified Bethesda assay, was not detected in this patient.
Croatian: Inhibicijsko djelovanje izmjereno prema modificiranom testu Bethesda nije otkriveno kod ovog bolesnika.
English: No studies were performed on the mutagenic potential of Vihuma.
Croatian: Nisu provedena ispitivanja mutagenog potencijala lijeka Vihuma.
English: Factor VIII is necessary for the blood to form clots and stop bleeding.
Croatian: Faktor VIII je potreban krvi za stvaranje ugrušaka i zaustavljanje krvarenja.
English: These symptoms can be early symptoms of an anaphylactic shock.
Croatian: Ovi simptomi mogu biti rani simptomi anafilaktičkog šoka.
English: Twenty patients used median doses of more than 45 IU/kg.
Croatian: Dvadeset bolesnika koristilo je medijan doze veći od 45 IU/kg.
English: This will be checked by your doctor.
Croatian: Vaš liječnik će provjeriti je li to slučaj.
English: Keep the reconstituted solution at room temperature.
Croatian: Čuvajte rekonstituiranu otopinu na sobnoj temperaturi.
English: However, in some cases, especially in younger patients, more frequent injections or higher doses may be necessary.
Croatian: No u nekim slučajevima, pogotovo kod mlađih bolesnika, mogu biti potrebne češće injekcije ili veće doze.
English: Use the reconstituted solution immediately after reconstitution.
Croatian: Upotrijebite rekonstituiranu otopinu odmah nakon rekonstitucije.
English: In general, minor bleeds required slightly lower, and more severe bleeds required up to three-fold higher median doses.
Croatian: za slabija krvarenja bile su potrebne nešto manje doze, a za obilnija krvarenja bili su potrebni do tri puta veći medijani doze.
English: In patients with haemophilia A (inborn factor VIII deficiency), factor VIII is missing or not working properly.
Croatian: Kod bolesnika s hemofilijom A (urođeni nedostatak faktora VIII), faktor VIII nedostaje ili ne djeluje pravilno.
English: One International Unit (IU) of factor VIII activity is equivalent to the quantity of factor VIII in one ml of normal human plasma.
Croatian: Jedna međunarodna jedinica (IU) aktivnosti faktora VIII jednaka je količini faktora VIII u jednom ml normalne ljudske plazme.
English: Vihuma replaces the missing factor VIII and is used for treatment and prevention of bleeding in patients with haemophilia A and can be used for all age groups.
Croatian: Vihuma zamjenjuje faktor VIII koji nedostaje i koristi se za liječenje i sprječavanje krvarenja kod bolesnika s hemofilijom A i može se primjenjivati kod svih dobnih skupina.
English: Dose based on bodyweight may require adjustment in underweight or overweight patients.
Croatian: Doza temeljena na tjelesnoj težini može zahtijevati prilagodbu u bolesnika s preniskom ili prekomjernom tjelesnom težinom.
English: The risk of developing inhibitors is correlated to the severity of the disease as well as the exposure to factor VIII, this risk being highest within the first 20 exposure days.
Croatian: Rizik od razvijanja inhibitora u korelaciji je s težinom bolesti kao i s izloženošću faktoru VIII, a najveći je unutar prvih 20 dana izloženosti.
English: Haemophilia A is a sex-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII:C and results in profuse bleeding into joints, muscles or internal organs, either spontaneously or as results of accidental or surgical trauma.
Croatian: Hemofilija A je spolno vezani nasljedni poremećaj zgrušavanja krvi koji nastaje zbog smanjene razine faktora VIII:C i rezultira obilnim krvarenjem u zglobove, mišiće ili unutarnje organe, bilo spontano ili kao rezultat slučajne ili kirurške traume.
English: In total 986 bleeding episodes were treated with a median dose of 30.9 IU/kg.
Croatian: Ukupno je liječeno 986 epizoda krvarenja sa medijanom doze od 30,9 IU/kg.
English: If you forget to use Vihuma
Croatian: Ako ste zaboravili primijeniti Vihuma
English: There are no fertility data available.
Croatian: Nema podataka o plodnosti.
English: The amino acid sequence is comparable to the 90 + 80 kDa form of human plasma factor VIII (i.e. B-domain deleted).
Croatian: Slijed aminokiselina je usporediv s oblikom 90 + 80 kDa humanog plazmatskog faktora VIII (tj. s izbrisanom B-domenom).
English: This temperature should be maintained during reconstitution.
Croatian: Održavajte tu temperaturu tijekom rekonstitucije.
English: Required units = body weight (kg) x desired factor VIII rise (%) (IU/dl) x 0.5 (IU/kg per IU/dl)
Croatian: Potrebne jedinice = tjelesna težina (kg) x željeno povećanje faktora VIII (%) (IU/dl) x 0,5 (IU/kg po IU/dl)
English: Common side effects may affect up to 1 in 10 people Hypersensitivity, fever.
Croatian: Česte nuspojave mogu se javiti u do 1 na 10 osoba Preosjetljivost, vrućica.
English: Vihuma contains sodium
Croatian: Vihuma sadrži natrij
English: The powder should only be reconstituted with the supplied solvent (2.5 ml water for injections) using the supplied injection set.
Croatian: Prašak se mora rekonstituirati isključivo s isporučenim otapalom (2,5 ml vode za injekcije) pomoću isporučenog seta za injekcije.
English: A non-neutralizing anti-Factor VIII antibody was detected in one adult patient (see Table 1).
Croatian: Opis odabranih nuspojava Neneutralizirajuća antitijela na faktor VIII su opažena u jednog odraslog bolesnika (vidjeti Tablicu 1).
English: Octapharma AB Lars Forssells gata 23 112 75 Stockholm SWEDEN
Croatian: Octapharma AB Lars Forssells gata 23 112 75 Stockholm Švedska
English: No animal or human derived materials are added during the manufacturing process or to the final medicinal product.
Croatian: Lijeku tijekom postupka proizvodnje i konačnom lijeku nisu dodane tvari životinjskog ili ljudskog podrijetla.
English: If you have the impression that the effect of Vihuma is insufficient, talk to your doctor.
Croatian: Ako smatrate da učinak lijeka Vihuma nije dovoljan, razgovarajte s liječnikom.
English: The calculation of the required dose of factor VIII is based on the empirical finding that 1 International Unit (IU) factor VIII per kg body weight raises the plasma factor VIII activity by approximately 2% of normal activity or 2 IU/dl.
Croatian: Izračun potrebne doze faktora VIII temelji se na empirijskom nalazu da 1 međunarodna jedinica (IU) faktora VIII po kg tjelesne težine povećava aktivnost faktora VIII u plazmi za otprilike 2% normalne aktivnosti ili 2 IU/dl.
English: If symptoms of hypersensitivity occur, patients should be advised to discontinue use of the medicinal product immediately and contact their physician.
Croatian: Ako se pojave simptomi preosjetljivosti, potrebno je savjetovati bolesnike da smjesta moraju prekinuti s primjenom lijeka i obratiti se svom liječniku.
English: For intravenous use after reconstitution.
Croatian: Za intravensku primjenu nakon rekonstitucije.
English: Factor VIII level required (%) (IU/dL)
Croatian: Potrebna razina faktora VIII (%) (IU/dL)
English: In the case of major surgical interventions in particular, precise monitoring of the substitution therapy by means of coagulation analysis (plasma factor VIII activity) is indispensable.
Croatian: Osobito je u slučaju većih kirurških zahvata neophodno precizno praćenje nadomjesne terapije ispitivanjem koagulacije (aktivnosti faktora VIII u plazmi).
English: The posology is the same in adults and children, however, shorter dose intervals or higher doses may be necessary for children.
Croatian: Doziranje je jednako u djece i odraslih, međutim, kod djece mogu biti potrebni kraći intervali doziranja ili veće doze.
English: Repeat infusion every 12 to 24 hours for 3 to 4 days or more until pain and acute disability are resolved.
Croatian: Ponovite infuziju svakih 12 - 24 sati u razdoblju od 3 do 4 dana ili duže dok ne prestanu bolovi i akutna onesposobljenost.
English: Because factor VIII products may have to be given more often in children, a central venous access device (CVAD, an external connector allowing access to the bloodstream through a catheter without injection through the skin) may need to be fitted.
Croatian: Budući da se pripravci s faktorom VIII nekad moraju češće davati djeci, možda će se trebati postaviti centralni venski kateter (vanjski priključak koji omogućuje pristup krvotoku kroz kateter bez injekcije kroz kožu).
English: Very common side effects may affect more than 1 in 10 people Factor VIII inhibitors in previously untreated patients.
Croatian: Vrlo česte nuspojave mogu se javiti u više od 1 na 10 osoba Inhibitori faktora VIII u prethodno neliječenih bolesnika.
English: Weight adjusted subgroups
Croatian: Podskupine po težini
English: Treatment should be under the supervision of a physician experienced in the treatment of haemophilia.
Croatian: Liječenje mora biti pod nadzorom liječnika s iskustvom u liječenju hemofilije.
English: # Frequency is based on studies with all FVIII products which included patients with severe haemophilia A. PTPs = previously-treated patients, PUPs = previously-untreated patients
Croatian: # Učestalost se temelji na ispitivanjima sa svim lijekovima s faktorom VIII koja su uključivala bolesnike s teškom hemofilijom A. PTPs = prethodno liječeni bolesnici (engl. previously-treated patients), PUPs = prethodno neliječeni bolesnici (engl. previously-untreated patients)
English: In patients with high levels of inhibitor, factor VIII therapy may not be effective and other therapeutic options should be considered.
Croatian: bolesnika s visokim razinama inhibitora, terapija faktorom VIII možda neće biti učinkovita te je potrebno razmotriti druge terapijske opcije.
English: Vihuma is produced by recombinant DNA technology in genetically modified human embryonic kidney (HEK) 293F cells.
Croatian: Vihuma se proizvodi tehnologijom rekombinantne DNK u genetski modificiranim stanicama bubrega ljudskog embrija 293F.
English: The median consumption of Vihuma for prophylaxis per month was 521.9 IU/kg.
Croatian: Medijan potrošnje lijeka Vihuma za potrebe profilakse po mjesecu iznosio je 521,9 IU/kg.
English: In patients with existing cardiovascular risk factors, substitution therapy with FVIII may increase the cardiovascular risk.
Croatian: U bolesnika s postojećim kardiovaskularnim faktorima rizika, nadomjesnu terapiju faktorom VIII može povećati kardiovaskularni rizik.
English: (<1/10,000), not known (cannot be estimated from the available data).
Croatian: (≥1/ 000 i <1/100); rijetko (≥1/10 000 i <1/1000); vrlo rijetko (<1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: None of the patients developed inhibitors.
Croatian: Inhibitori se nisu razvili ni u jednog bolesnika.
English: Repeat infusion every 8 to 24 hours until threat is resolved.
Croatian: Ponovite infuziju svakih 8 - 24 sati dok ne dođe do poboljšanja.
English: Allow the solvent syringe (water for injections) and the powder in the closed vial to reach room temperature.
Croatian: Pričekajte da štrcaljka s otapalom (voda za injekcije) i prašak u zatvorenoj bočici dosegnu sobnu temperaturu.
English: The following table can be used to guide dosing in bleeding episodes and surgery.
Croatian: Koristite sljedeću tablicu kao vodič za doziranje u slučajevima krvarenja i tijekom operacije.
English: In preclinical studies, Vihuma was used to safely and effectively restore haemostasis in dogs with haemophilia.
Croatian: U nekliničkim ispitivanjima lijek Vihuma se koristio za siguran i učinkovit povrat hemostaze u pasa s hemofilijom.
English: The powder is a white to offwhite friable powder in a glass vial.
Croatian: Rastresit prašak je bijele do gotovo bijele boje u staklenoj bočici.
English: Frequencies have been evaluated according to the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare
Croatian: Učestalosti su procijenjene na sljedeći način: vrlo često (≥1/10); često (≥1/100 i <1/10); manje često
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the marketing authorisation and any agreed subsequent updates of the RMP.
Croatian: • Plan upravljanja rizikom (RMP) Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: Simoctocog alfa (human coagulation factor VIII (rDNA)) is a purified protein that has 1440 amino acids.
Croatian: Simoktokog alfa (ljudski koagulacijski faktor VIII (rDNK)) je pročišćeni protein koji ima 1440
English: AUC = Area under the curve (FVIII:C), T1/2 = Terminal half-life, IVR = Incremental in vivo recovery, CL = Clearance, SD = Standard deviation
Croatian: AUC = Površina ispod krivulje (FVIII:C), T1/2 = Terminalni poluvijek, IVP = Inkrementalni in vivo povrat, CL = Klirens, SD = standardna devijacija
English: Treatment with Vihuma will be started by a doctor who is experienced in the care of patients with haemophilia A. Always use this medicine exactly as your doctor or nurse has told you.
Croatian: Liječenje lijekom Vihuma započet će liječnik s iskustvom u liječenju bolesnika s hemofilijom A. Uvijek primjenjujte ovaj lijek u skladu s uputama svog liječnika ili medicinske sestre.
English: The immunogenicity of Vihuma was evaluated in clinical trials in 190 previously treated patients with severe haemophilia A (129 adult and 61 paediatric patients).
Croatian: Imunogenost lijeka Vihuma je procijenjena u kliničkim ispitivanjima na 190 prethodno liječenih bolesnika s teškom hemofilijom A (129 odraslih i 61 pedijatrijski bolesnik).
English: Normal weight: BMI 18.5-25 kg/m2, Pre-adipose: BMI 25-30 kg/m2, Adipose: BMI > 30 kg/m2, SD = Standard deviation
Croatian: Normalna težina: ITM 18,5 - 25 kg/m2, Prekomjerna tjelesna težina: ITM 25 - 30 kg/m2, Pretilost: ITM > 30 kg/m2, SD = standardna devijacija
English: This medicine contains less than 1 mmol sodium (23 mg) per vial.
Croatian: Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po bočici.
English: As with any intravenous protein product, allergic type hypersensitivity reactions are possible.
Croatian: Kao i kod svakog lijeka za intravensku primjenu koji sadrži proteine, moguće su alergijske reakcije preosjetljivosti.
English: Activated factor VIII acts as a cofactor for activated factor IX, accelerating the conversion of factor X to activated factor X. Activated factor X converts prothrombin into thrombin.
Croatian: Aktivirani faktor VIII djeluje kao kofaktor aktiviranom faktoru IX te ubrzava pretvorbu faktora X u aktivirani faktor X.
English: Table 1 presented below is according to the MedDRA system organ classification (SOC and Preferred Term Level).
Croatian: Tablica 1 u nastavku usklađena je s Klasifikacijom organskih sustava MedDRA-e (klasifikacije organskih sustava i razine preporučenih pojmova).
English: IVR (%/IU/kg)
Croatian: IVP (%/IU/kg)
English: Treatment of bleeding: The median dose to treat break-through bleeding episodes was 33.0 IU/kg in these patients who were on prophylaxis.
Croatian: Liječenje krvarenja: Medijan doze za liječenje epizoda probojnih krvarenja iznosio je 33,0 IU/kg u bolesnika liječenih profilaksom.
English: Repeat infusion every 8-24 hours until adequate wound healing, then therapy for at least another 7 days to maintain a factor VIII activity of 30% to 60% (IU/dL).
Croatian: Ponovite infuziju svakih 8 - 24 sati do odgovarajućeg cijeljenja rane, a zatim nastavite liječenje najmanje 7 dana radi održavanja aktivnosti faktora VIII od 30% do 60%(IU/dL).
English: The solution should be clear and colourless, practically free from visible particles.
Croatian: Otopina mora biti bistra i bezbojna i gotovo u potpunosti bez vidljivih čestica.
English: Warnings and precautions Talk to your doctor or pharmacist before using Vihuma.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primijenite Vihuma.
English: By replacement therapy the plasma levels of factor VIII are increased, thereby temporarily enabling a correction of the factor VIII deficiency and correction of the bleeding tendencies.
Croatian: Nadomjesnom terapijom povećava se razina faktora VIII u plazmi, a time se omogućuje privremeno ispravljanje nedostatka faktora VIII i liječenje povećane sklonosti krvarenju.
English: A prospective open-label clinical study in PUPs with severe haemophilia A (<1% FVIII:C) is ongoing.
Croatian: U tijeku je prospektivno otvoreno kliničko ispitivanje u prethodno neliječenih bolesnika s teškom hemofilijom A (<1% FVIII:C).
English: The solution is now prepared for immediate use.
Croatian: Otopina je pripremljena i potrebno ju je odmah primijeniti.
English: Other medicines and Vihuma Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako primjenjujete, nedavno ste primijenili ili biste mogli primijeniti bilo koje druge lijekove.
English: Factor VIII activity in plasma is expressed either as a percentage (relative to normal human plasma) or preferably in International Units (relative to an International Standard for factor VIII in plasma).
Croatian: Aktivnost faktora VIII u plazmi izražena je u obliku postotka (u odnosu na normalnu ljudsku plazmu) ili po mogućnosti u međunarodnim jedinicama (prema međunarodnom standardu za faktor VIII u plazmi).
English: Do not use solutions that are cloudy or have deposits.
Croatian: Ne koristite otopine koje su mutne ili imaju talog.
English: Clean the chosen injection site with one of the provided alcohol swabs.
Croatian: Očistite željeno mjesto ubrizgavanja jednim od isporučenih jastučića natopljenih alkoholom.