FrancophonIA/ELRC3.0 huggingface dataset:
English: During in vitro studies, cloned human cardiac potassium channel (hERG), was inhibited by 15% at a concentration (30 μM) of atazanavir corresponding to 30 fold the free drug concentration at cmax in humans.
Lithuanian: 15%, esant tokiai atazanaviro koncentracijai (30 μM), kuri atitinka 30 kartų didesnę vaisto koncentraciją nei Cmax žmonėms.
English: In the majority of patients with at least one functional CYP2C19 allele, a reduction in both voriconazole and atazanavir exposures are expected.
Lithuanian: CYP2C19 alelis, sumažės ekspozicija tiek vorikonazolu, tiek atazanaviru.
English: Hard gelatine capsule, size no. 1.
Lithuanian: Kieta želatinos kapsulė, dydis numeris 1.
English: Atazanavir AUC: ↑250% (↑144%
Lithuanian: Pibrentasviro AUC: ↑64% (↑48% ↑82%)
English: Atazanavir should not be used in combination with medicinal products that are substrates of CYP3A4 and have a narrow therapeutic index.
Lithuanian: Todėl Atazanavir Krka kartu su ritonaviru neturi būti skiriamas kartu su siauro terapinio indekso vaistiniais preparatais, kurie yra CYP3A4 substratai (pvz.
English: Desacetyl-diltiazem AUC ↑165% Desacetyl-diltiazem cmax ↑172% Desacetyl-diltiazem cmin ↑121%
Lithuanian: Desacetil-diltiazemo Cmax ↑172% (↑144% Desacetil-diltiazemo Cmin ↑121% (↑102%
English: Rifampicin is a strong CYP3A4 inducer and has been shown to cause a 72% decrease in atazanavir AUC which can result in virological failure and resistance development.
Lithuanian: Rifampicinas yra stiprus CYP3A4 induktorius; nustatyta, kad jis 72%
English: b Number of patients evaluable.
Lithuanian: e Pacientų, kurių duomenys įvertinti, skaičius.
English: 229 (n=14b)
Lithuanian: 229 (n=14
English: CYP3A inhibition.
Lithuanian: Pgp ir CYP3A.
English: shellac black ferric oxide (E172)
Lithuanian: Juodais geležies oksidas (E172)
English: How to store Atazanavir Krka Contents of the pack and other information
Lithuanian: Atazanavir Krka išvaizda ir kiekis pakuotėje
English: Co-administration of atazanavir with triazolam or orally administered midazolam is contraindicated (see section 4.3), whereas caution should be used with co- administration of atazanavir and parenteral midazolam.
Lithuanian: 4.3 skyrių), o kartu atazanaviro su parenteriniu midazolamu reikia skirti atsargiai.
English: In HIV-infected adult patients (n=33, combined studies) the mean half-life within a dosing interval for atazanavir was 12 hours at steady state following a dose of 300 mg daily with ritonavir 100 mg once daily with a light meal.
Lithuanian: ŽIV infekuotiems pacientams (n= 33, apibendrinti tyrimų duomenys), vartojusiems kartotines atazanaviro 300 mg kartą per parą su ritonaviro 100 mg kartą per parą dozes su maistu,
English: atazanavir AUC ↓ 35% atazanavir cmax ↓ 25% atazanavir cmin ↓ 49%
Lithuanian: Atazanaviro Cmax ↓ 25% Atazanaviro Cmin ↓ 49%
English: The geometric mean (CV%) for atazanavir cmin and AUC were 120 (109) ng/ml and 14874 (91) ng•h/ml, respectively.
Lithuanian: Atazanaviro Cmin geometrinis vidurkis buvo 120 ng/ml (CV - 109 %),
English: Hard gelatine capsule (capsule), size no. 0.
Lithuanian: Kieta želatinos kapsulė (kapsulė), dydis numeris 0.
English: - It is not recommended to use Atazanavir Krka with ritonavir for pregnant patients who are receiving both tenofovir disoproxil and an H2-receptor antagonist.
Lithuanian: - Nėščioms pacientėms, kurios kartu vartoja tenofoviro dizoproksilo ir H2 receptorių blokatoriaus,
English: A large prospective observational study has shown an association between an increased incidence of chronic kidney disease and cumulative exposure to atazanavir/ritonavir-containing regimen in HIV-infected patients with an initially normal eGFR.
Lithuanian: Vaistiniam preparatui patekus į rinką ŽIV infekuotiems pacientams gydytiems atazanaviru, su arba be ritonaviro, buvo stebėta lėtinė inkstų liga. Dideliame prospektyviniame stebėjimo tyrime buvo nustatytas ryšys tarp padažnėjusių lėtinės inkstų ligos atvejų ir kaupiamojo gydymo atazanaviru/ritonaviru poveikio ŽIV sergantiems pacientams su normaliu apskaičiuotu glomerulų filtracijos greičiu (aGFG) tyrimo pradžioje.
English: with atazanavir is contraindicated (see section 4.3)
Lithuanian: Atazanaviro draudžiama skirti kartu su alfuzozinu (žr. 4.3 skyrių).
English: Atazanavir AUC ↔0% (↓9% Atazanavir cmax ↑17% (↑8% Atazanavir cmin ↓42% (↓51%
Lithuanian: Atazanaviro AUC ↔0%(↓9% ↑10%)* Atazanaviro Cmax ↑17%(↑8% ↑27%)* Atazanaviro Cmin ↓42%(↓51% ↓31%)*
English: (atazanavir 300 mg / ritonavir 100 mg once daily)
Lithuanian: (atazanaviro 300 mg/ritonaviro 100
English: Treatment of overdose with Atazanavir Krka should consist of general supportive measures, including monitoring of vital signs and electrocardiogram (ECG), and observations of the patient's clinical status.
Lithuanian: Perdozavus Atazanavir Krka gydymui reikia taikyti bendras palaikomąsias priemones, stebėti paciento gyvybines funkcijas, sekti elektrokardiogramą (EKG) ir paciento klinikinę būklę. Jei reikia, galima pašalinti nerezorbuotą atazanavirą, sukeliant vėmimą ar plaunant skrandį.
English: In case of withdrawal of ritonavir from the initial recommended ritonavir boosted regimen (see section 4.4), unboosted Atazanavir Krka could be maintained in patients with mild hepatic impairment at a dose of 400 mg, and in patients with moderate hepatic impairment with a reduced dose of 300 mg once daily with food (see section 5.2).
Lithuanian: 4.4 skyrių), lengvai sutrikusią kepenų funkciją turintiems pacientams gali būti tęsiamas nesustiprintas gydymas Atazanavir Krka 400 mg doze, o turintiems vidutiniškai sutrikusią kepenų funkciją - sumažinta 300
English: A dose equivalent to famotidine 40 mg twice daily should not be exceeded.
Lithuanian: Famotidino po 40 mg du kartus per parą
English: The M184V substitution in reverse transcriptase, which confers resistance to lamivudine and emtricitabine, was detected in 2 subjects in the unboosted atazanavir and 1 subject in the atazanavir + ritonavir group.
Lithuanian: Atvirkštinės transkriptazės M184V pakeitimas, sukeliantis atsparumą lamivudinui ir emtricitabinui,
English: Elbasvir 50 mg once daily (atazanavir 300 mg/ ritonavir 100 mg once daily)
Lithuanian: Elbasviro 50 mg kartą per parą atazanaviro 300 mg/ritonaviro 100
English: tenofovir disoproxil fumarate in treatment- experienced patients has been demonstrated in clinical study 045 and in treatment naive patients in clinical study 138 (see sections 4.8 and 5.1).
Lithuanian: Atazanaviro / ritonaviro derinio su tenofoviru dizoproksilo fumaratu veiksmingumas gydant anksčiau antiretrovirusiniais preparatais gydytus ligonius buvo akivaizdžiai įrodytas klinikinio tyrimo 045 metu, o derinio skiriant anksčiau negydytiems ligoniamsįrodytas klinikinio tyrimo 138 metu
English: Patients co-infected with hepatitis B and/or hepatitis C virus Among 1,151 patients receiving atazanavir 400 mg once daily, 177 patients were co-infected with chronic hepatitis B or C, and among 655 patients receiving atazanavir 300 mg once daily with ritonavir 100 mg once daily, 97 patients were co-infected with chronic hepatitis B or C. Coinfected patients were more likely to have baseline hepatic transaminase elevations than those without chronic viral hepatitis.
Lithuanian: Iš 1 151 ligonio, gydyto 400 mg atazanaviro kartą per parą, 177 pacientai dar sirgo lėtiniu B ar C hepatitu.
English: Atazanavir AUC ↓87% (↓92%
Lithuanian: Atazanaviro AUC ↓23% (↓32% ↓14%)
English: Metabolic parameters Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section
Lithuanian: Gydymo antiretrovirusiniais vaistiniais preparatais metu gali padidėti kūno masė ir lipidų bei gliukozės koncentracijos kraujyje (žr. 4.4 skyrių).
English: Atazanavir AUC ↓61% (↓65%
Lithuanian: Atazanaviro AUC ↓ 35%
English: Co-administration with medicinal products that are substrates of the CYP3A4 isoform of cytochrome P450 and have narrow therapeutic windows (e.g., quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine, bepridil, triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5), and ergot alkaloids, particularly, ergotamine, dihydroergotamine, ergonovine, methylergonovine) (see section 4.5).
Lithuanian: cisapridas, pimozidas, chinidinas, bepridilis, triazolamas, geriamasis midazolamas (dėl atsargumo priemonių vartojant parenterinio midazolamo žr. 4.5 skyrių) ir skalsių alkaloidai, ypač ergotaminas,
English: Cholelithiasis
Lithuanian: Šelakas
English: Mean urinary excretion of unchanged drug was 7% following 2 weeks of dosing at 800 mg once daily.
Lithuanian: Vartojant 800 mg vieną kartą per parą, su šlapimu dar 2 sekančias savaites pasišalindavo 7%
English: The mechanism of interaction is CYP3A4 inhibition by atazanavir and/or ritonavir.
Lithuanian: Vaistinių preparatų sąveiką lemia atazanaviro ir (arba) ritonaviro sukeliamas CYP3A4 slopinimas.
English: Atazanavir AUC ↓20% (↓35% Atazanavir cmax ↓19% (↓34% Atazanavir cmin ↓ 31 % (↓46 %
Lithuanian: Atazanaviro AUC ↓20% (↓35% ↓3%) Atazanaviro Cmax ↓19% (↓34% ↔0.2%) Atazanaviro Cmin ↓ 31 % (↓46 % ↓13%)
English: - Gallbladder problems uncommonly happen in people taking atazanavir.
Lithuanian: - Atazanaviro vartojantiems žmonėms nedažnai atsiranda tulžies pūslės sutrikimų.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING CONTAINER LABEL
Lithuanian: INFORMACIJA ANT VIDINĖS PAKUOTĖS
English: - interstitial nephritis (kidney inflammation), haematuria (blood in the urine), proteinuria (excess protein in the urine), pollakiuria (increased frequency of urination) - gynaecomastia (breast enlargement in men) - chest pain, malaise (generally feeling unwell), fever - insomnia (difficulty sleeping)
Lithuanian: (padidėjęs baltymo kiekis šlapime), poliakiurija (padažnėjęs šlapinimasis); - ginekomastija (padidėjusios krūtys vyrams); - krūtinės skausmas, negalavimas (prasta bendra savijauta), karščiavimas; - nemiga (negalėjimas užmigti).
English: Atazanavir Krka with ritonavir is not recommended in patients undergoing haemodialysis (see sections 4.4 and 5.2).
Lithuanian: Atazanavir Krka su ritonaviru nerekomenduojama vartoti pacientams, kuriems atliekama hemodializė (žr.
English: Ketoconazole and itraconazole should be used cautiously with atazanavir /ritonavir, high doses of ketoconazole and itraconazole (>200 mg/day) are not recommended.
Lithuanian: Didelių ketokonazolo ir itrakonazolo dozių (> 200 mg per parą) skirti nerekomenduojama.
English: HIV RNA <100,000 copies/ml
Lithuanian: <100 000 kopijų/ml ≥100 000 kopijų/ml
English: Atazanavir Krka 200 mg hard capsules
Lithuanian: Atazanavir Krka 200 mg kietosios kapsulės
English: Atazanavir AUC ↓19% (↓35% Atazanavir cmax ↔2% (↓15% Atazanavir cmin ↓59% (↓73%
Lithuanian: Atazanaviro AUC ↓19% (↓35% ↑2%)* Atazanaviro Cmax ↔2% (↓15% ↑24%)* Atazanaviro Cmin ↓59%(↓73% ↓40%)*
English: Coadministration of diltiazem and atazanavir /ritonavir has not been studied.
Lithuanian: Poveikis atazanaviro ir ritonaviro ekspozicijai nėra ištirtas.
English: Co-administration of atazanvir with glecaprevir/pibrentasvir is contraindicated because of the potential increase in the risk of ALT elevations due to a significant increase in glecaprevir and pibrentasvir plasma concentrations (see section 4.3)
Lithuanian: Atazanaviro negalima vartoti kartu su glekapreviru/pibrentasviru dėl galimos ALT koncentracijos padidėjimo rizikos, kuri susijusi su žymiu padidėjimu glekapreviro ir pibrentasviro koncentracijų kraujo plazmoje (žr.
English: Hard gelatine capsule, size no. 0.
Lithuanian: Kieta želatinos kapsulė, dydis numeris 0.
English: Atazanavir AUC ↓30% (↓43% Atazanavir cmax ↓31% (↓42% Atazanavir cmin ↓31% (↓46%
Lithuanian: Atazanaviro AUC ↓30% (↓43% ↓14%)* Atazanaviro Cmax ↓31% (↓42% ↓17%) * Atazanaviro Cmin ↓31% (↓46% ↓12%)*
English: Atazanavir AUC ↓22% (↓35% Atazanavir cmax ↓16% (↓30% Atazanavir cmin ↓23% (↓43% ↑2%)
Lithuanian: Atazanaviro AUC ↓22% (↓35% ↓6%)* Atazanaviro Cmax ↓16% (↓30% ↔0%)* Atazanaviro Cmin ↓23% (↓43% ↑2%)*
English: Co-administration of atazanvir with voxilaprevircontaining regimens is not recommended.
Lithuanian: Atazanaviro nerekomenduojama vartoti kartu su vaistiniais preparatais, kurių sudėtyje yra voksilapreviro.
English: Atazanavir cmax ↓66% (↓62%
Lithuanian: Atazanaviro Cmax ↓23% (↓33% ↓12%)
English: Atazanavir AUC ↑7% (↓2% Atazanavir cmax ↑2% (↓4% ↑8%) Atazanavir cmin ↑15% (↑2% ↑29%) Elbasvir AUC: ↑376% (↑307% Elbasvir cmax: ↑315% (↑246% Elbasvir cmin: ↑545% (↑451%
Lithuanian: Elbasviro AUC ↑376% (↑307% ↑456%) Elbasvir Cmax ↑315% (↑246% ↑397%) Elbasvir Cmin ↑545% (↑451% ↑654%)
English: , vesiculobullous rash, eczema,
Lithuanian: reti: hepatosplenomegalija, cholecistitasa.
English: Caution should be exercised when verapamil is coadministered with atazanavir.
Lithuanian: Verapamilio kartu su atazanaviru reikia skirti atsargiai.
English: All patients HIV RNA <400 copies/ml, %
Lithuanian: ŽIV RNR <400 kopijų/ml, %a
English: 100 mg a
Lithuanian: 100 mg
English: Atazanavir cmin: ↑713% (↑359%
Lithuanian: Glecapreviro AUC: ↑553% (↑424%
English: Difference estimate [95% CI]
Lithuanian: [95% PI]
English: Hard gelatine capsule, size no. 00.
Lithuanian: Kieta želatinos kapsulė, dydis numeris 00.
English: Concentrations of these antiarrhythmics may be increased when co-administered with atazanavir.
Lithuanian: Skiriant šių vaistinių preparatų kartu su atazanaviru, gali padidėti šių antiaritminių vaistinių preparatų koncentracijos.
English: Didanosine (buffered tablets) 200 mg/stavudine 40 mg, both single dose (atazanavir 400 mg single dose)
Lithuanian: Didanozino (buferinių tablečių pavidalu) 200 mg / stavudino
English: c Lopinavir/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
Lithuanian: c Lopinaviras/RTV su tenofoviro dizoproksilo fumaratu/emtricitabinu (fiksuotos dozės 300 mg/200 mg tabletės kartą per parą).
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each hard capsule contains 200 mg atazanavir (as sulphate).
Lithuanian: VEIKLIOJI (-IOS) MEDŽIAGA (-OS) IR JOS (-Ų) KIEKIS (-IAI) Kiekvienoje kietojoje kapsulėje yra 200 mg atazanaviro (atazanaviro sulfato pavidalu).
English: Atazanavir AUC ↓12% (↓18% Atazanavir cmax ↓13% (↓20% Atazanavir cmin ↓ 20 % (↓28%
Lithuanian: Atazanaviro AUC ↓12% (↓18% ↓5%) Atazanaviro Cmax ↓13% (↓20% ↓4%) Atazanaviro Cmin ↓ 20 % (↓28 % ↓10%)
English: ANTIFUNGALS Ketoconazole 200 mg once daily (atazanavir 400 mg once daily)
Lithuanian: PRIEŠGRYBELINIAI VAISTINIAI PREPARATAI Ketokonazolo 200 mg kartą per parą (atazanaviro 400 mg kartą per parą)
English: aphthous (mouth ulcers and cold sores), dysgeusia (impairment of the sense of taste),
Lithuanian: (burnos gleivinės išopėjimas ir žaizdos), dizgeuzija (skonio jutimo sutrikimas), meteorizmas
English: Co-administration of Atazanavir Krka with proton pump inhibitors is not recommended (see section 4.5).
Lithuanian: Atazanavir Krka nerekomenduojama skirti kartu su protonų siurblio inhibitoriais (žr.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each hard capsule contains 300 mg atazanavir (as sulphate).
Lithuanian: VEIKLIOJI (-IOS) MEDŽIAGA (-OS) IR JOS (-Ų) KIEKIS (-IAI) Kiekvienoje kietojoje kapsulėje yra 300 mg atazanaviro (atazanaviro sulfato pavidalu).
English: Atazanavir cmin ↔12% (↓16%
Lithuanian: Atazanaviro Cmin ↓20% (↓31% ↓8%)
English: As a general rule, it is recommended that HIV infected women not breast-feed their infants in order to avoid transmission of HIV.
Lithuanian: kad ŽIV infekuotos moterys nemaitintų krūtimi kūdikių.
English: HCV Protease Inhibitors Boceprevir 800 mg three times daily (atazanavir 300 mg/ritonavir 100 mg once daily)
Lithuanian: Bocepreviro po 800 mg tris kartus per parą (atazanaviro 300 mg / ritonaviro
English: Posology
Lithuanian: DĖŽUTĖ
English: Co-administration of atazanavir with glecaprevir/pibrentasvir fixed dose combination is contraindicated because of the potential increase in the risk of ALT elevations due to a significant increase in glecaprevir and pibrentasvir plasma concentrations (see section 4.3).
Lithuanian: Atazanaviro negalima vartoti kartu su glekapreviro/pibrentasviro fiksuotų dozių deriniais dėl galimos alanino transaminazės (ALT) koncentracijos padidėjimo rizikos, kuri susijusi su žymiu padidėjimu glekapreviro ir pibrentasviro koncentracijų kraujo plazmoje (žr.
English: No drug interaction study has been performed for the coadministration of atazanavir with benzodiazepines.
Lithuanian: Benzodiazepinų vartojimo kartu su atazanaviru sąveikos tyrimų neatlikta.
English: No dose adjustment is needed for atazanavir.
Lithuanian: atazanaviro dozės koreguoti nereikia.
English: the clarithromycin/atazanavir interaction is CYP3A4 inhibition.
Lithuanian: Klaritromicino sąveiką su atazanaviru lemia CYP3A4 slopinimas.
English: The capsule cap is imprinted with white mark A300.
Lithuanian: Ant kapsulės dangtelio yra juodu rašalu užrašyta A300.
English: An increase in weight and in levels of blood lipids and glucose may occur during antiretroviral therapy.
Lithuanian: Gydymo antiretrovirusiniais vaistiniais preparatais metu gali padidėti kūno masė ir lipidų bei gliukozės koncentracijos kraujyje.
English: Nervous system disorders:
Lithuanian: Nervų sistemos sutrikimai dažni: galvos skausmas;
English: Study 045 is a randomised, multicenter trial comparing atazanavir /ritonavir (300/100 mg once daily) and atazanavir /saquinavir (400/1,200 mg once daily), to lopinavir + ritonavir (400/100 mg fixed dose combination twice daily), each in combination with tenofovir disoproxil (see sections 4.5 and 4.8) and one NRTI, in patients with virologic failure on two or more prior regimens containing at least one PI, NRTI, and NNRTI.
Lithuanian: (po 300 mg/100 mg kartą per parą) vartojimas su atazanaviro / sakvinaviro (po 400 mg/1 200 mg kartą per parą) ir su lopinaviro+ritonaviro (400 mg/100 mg fiksuotos dozės sudėtinio preparato du kartus per parą) vartojimu, kiekvieną iš jų skiriant kartu su tenofoviro dizoproksiliu (žr.
English: For patients not taking tenofovir disoproxil, if atazanavir 300 mg/ritonavir 100 mg and H2-receptor antagonists are co-administered, a dose equivalent to famotidine 20 mg twice daily should not be exceeded.
Lithuanian: Tenofoviro dizoproksilio nevartojantiems pacientams: jei atazanaviro 300 mg / ritonaviro 100 mg reikia skirti kartu su H2
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each hard capsule contains 150 mg atazanavir (as sulphate).
Lithuanian: VEIKLIOJI (-IOS) MEDŽIAGA (-OS) IR JOS (-Ų) KIEKIS (-IAI) Kiekvienoje kietojoje kapsulėje yra 150 mg atazanaviro (atazanaviro sulfato pavidalu).
English: Atazanavir AUC ↑43% (↑30% Atazanavir cmax ↑12% (↑1% Atazanavir cmin ↑23% (↑13% Grazoprevir AUC: ↑958% (↑678% Grazoprevir cmax: ↑524% (↑342% Grazoprevir cmin: ↑1064% (↑696%
Lithuanian: Atazanaviro AUC ↑43% (↑30% ↑57%) Atazanaviro Cmax ↑12% (↑1% ↑24%) Atazanaviro Cmin ↑23% (↑13% ↑134%)
English: Cap: titanium dioxide (E171) yellow ferric oxide (E172) red ferric oxide (E172) gelatine ink:
Lithuanian: Titano dioksidas (E171) Geltonasis geležies oksidas (E172) Raudonasis geležies oksidas (E172) Želatina
English: Co-administration of Atazanavir Krka and medicinal products that induce CYP3A4 is not recommended (see sections 4.3 and 4.5).
Lithuanian: Nerekomenduojama skirti Atazanavir Krka kartu su vaistiniais preparatais, indukuojančiais CYP3A4 (žr.
English: Co-administration of atazanavir and elbasvir/grazoprevir is contraindicated because of a significant increase in grazoprevir plasma concentrations and an associated potential increase in the risk of ALT elevations (see section
Lithuanian: Negalima vartoti atazanaviro kartu su elbasviru/grazopreviru dėl tikėtinos padidėjusios grazopreviro plazmos koncentracijos ir dėl susijusios galimos alanino transaminazės (ALT) koncentracijos padidėjimo rizikos
English: The recommended adult dose of Atazanavir Krka capsules is 300 mg once daily with 100 mg ritonavir once daily and with food, in combination with other anti-HIV medicines.
Lithuanian: Rekomenduojama Atazanavir Krka kapsulių dozė suaugusiesiems yra 300 mg 1 kartą per parą kartu su ritonaviro 100 mg 1 kartą per parą su maistu, derinant su kitais vaistais nuo ŽIV. Jūsų gydytojas gali pakoreguoti Atazanavir Krka dozę, priklausomai nuo kitų kartu vartojamų vaistų nuo
English: Co-administration of salmeterol and Atazanavir Krka is not recommended (see section 4.5).
Lithuanian: Nerekomenduojama skirti Atazanavir Krka kartu su atorvastatinu (žr. 4.5 skyrių).
English: Cap: titanium dioxide (E171), yellow ferric oxide (E172), red ferric oxide (E172), gelatine and ink (shellac, black ferric oxide (E172), potassium hydroxide
Lithuanian: Kapsulės dangtelis: titano dioksidas (E171), geltonasis geležies oksidas (E172), raudonasis geležies oksidas (E172), želatina ir rašalas (šelakas, juodasis geležies oksidas (E172),kalio hidroksidas)
English: Capsule shell of Atazanavir Krka 200 mg hard capsules Body: titanium dioxide (E171), yellow ferric oxide (E172), red ferric oxide (E172) and gelatine Cap: titanium dioxide (E171), yellow ferric oxide (E172), red ferric oxide (E172), gelatine and ink (shellac, black ferric oxide (E172), potassium hydroxide
Lithuanian: Kapsulės korpusas: titano dioksidas (E171), želatina Kapsulės dangtelis: titano dioksidas (E171), geltonasis geležies oksidas (E172), raudonasis geležies oksidas (E172), želatina ir rašalas (šelakas, juodasis geležies oksidas (E172),kalio hidroksidas)
English: In antiretroviral experienced adult patients
Lithuanian: kuriame dalyvavo anksčiau negydyti pacientai.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Atazanavir Krka 150 mg hard capsules Each hard capsule contains 150 mg atazanavir (as sulphate).
Lithuanian: KOKYBINĖ IR KIEKYBINĖ SUDĖTIS Atazanavir Krka 150 mg kietosios kapsulės
English: NAME OF THE MEDICINAL PRODUCT Atazanavir Krka 150 mg hard capsules
Lithuanian: Pakuotės lapelis: informacija pacientui Atazanavir Krka 150 mg kietosios kapsulės
English: Atazanavir, dosed 1 hr after ddI+d4T (fasted) Atazanavir AUC ↔3% (↓36% Atazanavir cmax ↑12% (↓33% Atazanavir cmin ↔3% (↓39%
Lithuanian: Atazanaviro AUC ↔3% (↓36% ↑67%) Atazanaviro Cmax ↑12% (↓33% ↑18%) Atazanaviro Cmin ↔3% (↓39% ↑73%)
English: Cap: titanium dioxide (E171) yellow ferric oxide (E172) red ferric oxide (E172) black ferric oxide (E172) gelatine ink:
Lithuanian: Titano dioksidas (E171) Geltonasis geležies oksidas (E172) Raudonasis geležies oksidas (E172) Juodasis geležies oksidas (E172) Želatina
English: What Atazanavir Krka contains - The active substance is atazanavir.
Lithuanian: - Veiklioji medžiaga yra atazanaviras.
English: 150 mg hard capsules: 60 hard capsules: EU/1/19/1353/001
Lithuanian: 60 kietųjų kapsulių: EU/1/19/1353/001
English: Norethindrone cmax ↑67% (↑42% Norethindrone cmin ↑262%
Lithuanian: iki ↑ 162 %) Noretindrono Cmax ↑ 67 % (nuo ↑ 42 % iki
English: Glecaprevir AUC : ↑553% Glecaprevir cmax : ↑306% (↑215% Glecaprevir cmin : ↑1330% (↑885% Pibrentasvir AUC : ↑64% (↑48% Pibrentasvir cmax : ↑29% (↑15% Pibrentasvir cmin: ↑129% (↑95%
Lithuanian: Glecapreviro Cmax: ↑306% (↑215% Glecapreviro Cmin: ↑1330% (↑885%
English: NAME OF THE MEDICINAL PRODUCT Atazanavir Krka 200 mg hard capsules atazanavir
Lithuanian: Atazanavir Krka 200 mg kietosios kapsulės atazanaviras
English: 100 to <200 cells/mm
Lithuanian: nuo 100 iki <200
English: Although not studied, similar results are expected with other proton pump inhibitors.
Lithuanian: panašų poveikį gali sukelti ir kiti protonų siurblio inhibitoriai.
English: Absorption: in HIV-infected patients (n=33, combined studies), multiple dosing of atazanavir 300 mg once daily with ritonavir 100 mg once daily with food produced a geometric mean (CV%) for atazanavir, cmax of 4466 (42%) ng/ml, with time to cmax of approximately 2.5 hours.
Lithuanian: ŽIV infekuotiems suaugusiems pacientams (n= 33, apibendrinti tyrimų duomenys) vartojant 300 mg atazanaviro kartu su 100 mg ritonaviro kartą per parą su lengvu maistu, vidutinis atazanaviro pusinės eliminacijos periodas tarp dozių buvo 12 val.
English: CD4 Mean Change from Baseline, cells/mm All patients
Lithuanian: Vidutinis CD4 skaičiaus pokytis nuo pradinio, ląstelių/mm