FrancophonIA/ELRC3.0 huggingface dataset:
English: It is currently unknown whether venetoclax may reduce the effectiveness of hormonal contraceptives, and therefore women using hormonal contraceptives should add a barrier method.
Croatian: Trenutno nije poznato može li venetoklaks smanjiti učinkovitost hormonskih kontraceptiva, pa žene koje koriste hormonske kontraceptive trebaju dodatno koristiti i mehaničku kontracepciju.
English: Dose-titration schedule
Croatian: Raspored titracije doze
English: Your doctor may need to stop certain medicines when you first start taking Venclyxto and during the first five weeks when your dose is gradually increased to the full standard dose.
Croatian: Liječnik će možda morati prekinuti primjenu određenih lijekova kada tek počnete uzimati Venclyxto i tijekom prvih pet tjedana njegove primjene, tijekom kojih se doza postupno povećava do pune standardne doze.
English: Dose at interruption (mg)
Croatian: Doza u trenutku privremenog prekida (mg)
English: This will help to remove cancer cell breakdown products from your blood through your urine.
Croatian: To će pomoći da se razgradni produkti stanica raka uklone iz krvi kroz mokraću.
English: Unstratified hazard ratio is displayed on the X-axis with logarithmic scale.
Croatian: Nestratificiran omjer hazarda prikazan je na X-osi, logaritamskom ljestvicom.
English: Tell your doctor immediately if you have signs of an infection while taking this medicine.
Croatian: Odmah obavijestite svog liječnika ako primijetite znakove infekcije dok uzimate ovaj lijek.
English: - Tell your doctor immediately if you become pregnant while you are taking this medicine.
Croatian: - Odmah recite svom liječniku ako zatrudnite dok uzimate ovaj lijek.
English: A larger dose reduction may occur at the discretion of the physician.
Croatian: Smanjenja doze mogu biti i veća, prema odluci liječnika.
English: Of the 130 patients, 92 patients completed the 6-month post treatment follow-up visit.
Croatian: Od tih 130 bolesnika, njih 92 dovršila su posjet radi praćenja 6 mjeseci nakon liječenja.
English: Date of first authorisation: 5 December 2016 Date of latest renewal: 6 September 2018
Croatian: Datum posljednje obnove odobrenja: 6. rujna 2018.
English: MRD negativity was defined as a result below 0.0001 (<1 CLL cell per 104 leukocytes in the sample).
Croatian: Negativan nalaz na MRD definirao se kao rezultat manji od 0,0001 (< 1 stanice KLL-a na 104 leukocita u uzorku).
English: If you are using hormonal contraceptive pills or devices, you must also use a barrier method of contraception (such as condoms) as the effect of hormonal contraceptive pills or devices may be affected by Venclyxto.
Croatian: Ako koristite hormonske kontracepcijske pilule ili pomagala, morate koristiti i mehaničku metodu kontracepcije (poput prezervativa) jer Venclyxto može utjecati na učinak hormonskih kontracepcijskih pilula ili pomagala.
English: It is important that you tell your doctor, pharmacist, or nurse about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Croatian: Važno je da obavijestite svog liječnika, ljekarnika ili medicinsku sestru o svim lijekovima koje uzimate, uključujući lijekove na recept i bez recepta, vitamine i biljne dodatke prehrani.
English: Tell your doctor if you take any of the following medicines as Venclyxto may affect how they work:
Croatian: Obavijestite svog liječnika ako uzimate bilo koji od sljedećih lijekova, jer Venclyxto može utjecati na način njihova djelovanja:
English: Blood chemistries should be reassessed prior to each subsequent dose increase during the titration phase.
Croatian: Biokemijske parametre krvi treba ponovno odrediti prije svakog sljedećeg povećanja doze tijekom faze titracije.
English: The same monitoring schedule should be followed at the start of the 50 mg dose and then for patients who continue to be at risk, at subsequent dose increases.
Croatian: Istog se rasporeda praćenja treba pridržavati i na početku primjene doze od 50 mg, a zatim kod bolesnika koji su i dalje pod rizikom, pri svakom sljedećem povećanju doze.
English: Contents of the pack and other information What Venclyxto contains
Croatian: Sadržaj pakiranja i druge informacije Što Venclyxto sadrži
English: Take your dose at the same time each day with a meal and water.
Croatian: Uzmite dozu lijeka u isto vrijeme svaki dan, uz obrok i s vodom.
English: Median DOR was not reached with median follow up of approximately 23.8 months.
Croatian: Medijan trajanja odgovora nije dosegnut nakon medijana praćenja od približno 23,8 mjeseci.
English: - you are allergic to the active substance venetoclax or any of the other ingredients of this medicine (listed in section 6).
Croatian: - ako ste alergični na djelatnu tvar venetoklaks ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: If you vomit after taking Venclyxto, do not take an extra dose that day.
Croatian: Ako povratite nakon uzimanja lijeka Venclyxto, nemojte uzeti dodatnu dozu taj dan.
English: aThe modified dose should be continued for 1 week before increasing the dose.
Croatian: aLiječenje prilagođenom dozom treba nastaviti tijekom tjedan dana prije nego što se doza poveća.
English: Venetoclax shows minimal accumulation with accumulation ratio of 1.30-1.44.
Croatian: Venetoklaks pokazuje minimalnu kumulaciju, uz omjer kumulacije od 1,30 do 1,44.
English: All events of TLS occurred during the venetoclax dose-titration phase and resolved within two days.
Croatian: Svi događaji TLS-a javili su se tijekom faze titracije doze venetoklaksa i povukli su se unutar dva dana.
English: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor, pharmacist, or nurse for advice before taking this medicine.
Croatian: Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku, ljekarniku ili medicinskoj sestri za savjet prije nego uzmete ovaj lijek.
English: • you are due to have a vaccine.
Croatian: • ako trebate primiti cjepivo
English: Venetoclax is not recommended during pregnancy and in women of childbearing potential not using highly effective contraception.
Croatian: Primjena venetoklaksa ne preporučuje se tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste visoko učinkovitu kontracepciju.
English: IRC assessed
Croatian: Ocjena IRC-a
English: Venclyxto may be given to you in combination with rituximab or alone.
Croatian: Venclyxto možete primati u kombinaciji s rituksimabom ili samostalno.
English: • Take the tablets with a meal at around the same time each day
Croatian: • Uzmite tablete uz obrok približno u isto vrijeme svaki dan.
English: • upper respiratory tract infection - signs include runny nose, sore throat or cough
Croatian: • infekcija gornjih dišnih putova - znakovi uključuju curenje iz nosa, grlobolju ili kašalj
English: Efficacy results for PFS at the time of pre-specified primary analysis (data cut-off date 8 May 2017) are shown in Table 4.
Croatian: Rezultati za djelotvornost s obzirom na PFS u trenutku provedbe unaprijed specificirane primarne analize (završni datum prikupljanja podataka: 8. svibnja 2017.) prikazani su u Tablici 4.
English: Electrolyte abnormalities should be corrected promptly.
Croatian: Odstupanja u vrijednostima elektrolita potrebno je odmah korigirati.
English: Venclyxto is used to treat patients with chronic lymphocytic leukaemia (CLL) when the disease has come back or has not responded to other treatment.
Croatian: Venclyxto se koristi za liječenje bolesnika s kroničnom limfocitnom leukemijom (KLL) kada se bolest vratila ili kada nije odgovorila na neko drugo liječenje.
English: • you have liver problems as this may increase your risk for side effects.
Croatian: • ako imate jetrenih tegoba, jer to može povećati rizik od nuspojava.
English: Before starting treatment, counselling on sperm storage may be considered in some male patients.
Croatian: Prije započinjanja liječenja, u nekih bolesnika muškog spola može se razmotriti savjetovanje o pohrani sperme.
English: Unchanged venetoclax accounted for 20.8% of the administered radioactive dose excreted in faeces.
Croatian: Nepromijenjen venetoklaks činio je 20,8% primijenjene radioaktivne doze koja se izlučila kroz feces.
English: Tell your doctor, pharmacist or nurse immediately if you get any of the symptoms of TLS listed in section 4.
Croatian: Odmah obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako primijetite bilo koji od simptoma TLS-a navedenih u dijelu 4.
English: Venetoclax also caused single cell necrosis in various tissues, including the gallbladder and exocrine pancreas, with no evidence of disruption of tissue integrity or organ dysfunction; these findings were minimal to mild in magnitude.
Croatian: Venetoklaks je uzrokovao i nekrozu pojedinačnih stanica u različitim tkivima, uključujući žučni mjehur i egzokrino tkivo gušterače, bez dokaza narušavanja cjelovitosti tkiva ili disfunkcije organa; ti su nalazi bili minimalne do blage težine.
English: Venetoclax should be taken for 24 months from Cycle 1 Day 1 of rituximab (see section 5.1).
Croatian: Venetoklaks je potrebno uzimati tijekom 24 mjeseca od 1. dana 1. ciklusa primjene rituksimaba (vidjeti dio 5.1).
English: Venclyxto has no or negligible influence on the ability to drive and use machines.
Croatian: Venclyxto ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: bIncludes 51 additional patients from the safety expansion cohort.
Croatian: bUključuje 51 dodatnog bolesnika iz proširene kohorte za ispitivanje sigurnosti.
English: Venclyxto works by blocking a protein in the body called “BCL-2”.
Croatian: Venclyxto djeluje tako da blokira protein u tijelu koji se zove 'BCL-2'.
English: If you take more Venclyxto than you should
Croatian: Ako uzmete više lijeka Venclyxto nego što ste trebali
English: Do not eat grapefruit products, Seville oranges (bitter oranges), or starfruit (carambola) while you are taking Venclyxto - this includes eating them, drinking the juice or taking a supplement that might contain them.
Croatian: Nemojte konzumirati proizvode od grejpa, gorke naranče (seviljske naranče) ni zvjezdasto voće (karambolu) dok uzimate Venclyxto - dakle, ne smijete jesti to voće, piti sok koji ga sadrži niti uzimati dodatke prehrani u kojima se ono nalazi.
English: Complete blood counts should be monitored throughout the treatment period.
Croatian: Tijekom cijelog razdoblja liječenja treba kontrolirati kompletnu krvnu sliku.
English: The instructions for “Prevention of tumour lysis syndrome” should be followed (see section 4.2).
Croatian: Treba slijediti upute za „Prevenciju sindroma lize tumora“ (vidjeti dio 4.2).
English: Patients should be assessed for risk and should receive appropriate prophylaxis for TLS, including hydration and anti-hyperuricaemics.
Croatian: Potrebno je procijeniti rizik u bolesnika i primijeniti odgovarajuću profilaksu za TLS, uključujući hidraciju i lijekove za hiperuricemiju.
English: Dosing should be interrupted if needed (see section 4.2).
Croatian: Ako je potrebno, doziranje treba privremeno prekinuti (vidjeti dio 4.2).
English: - Do not get pregnant while you are taking this medicine.
Croatian: Ne smijete zatrudnjeti dok uzimate ovaj lijek.
English: The population estimate for apparent volume of distribution (Vdss/F) of venetoclax ranged from 256-321 L in patients.
Croatian: Procjena prividnog volumena distribucije (Vdss/F) venetoklaksa u populaciji bolesnika kretala se od 256 do 321 l.
English: No dose adjustment is needed during short-term use of azithromycin when administered concomitantly with venetoclax.
Croatian: Nije potrebna prilagodba doze tijekom kratkoročne primjene azitromicina kada se primjenjuje istodobno s venetoklaksom.
English: Drinking plenty of water, at least 1.5 to 2 litres per day, helps to remove cancer cell breakdown products from your body through urine, and may decrease your risk of getting TLS (see section 3).
Croatian: Pijenje velike količine vode, najmanje 1,5 do 2 litre na dan, pomaže ukloniti razgradne produkte stanica raka iz tijela kroz mokraću te može smanjiti rizik od razvoja TLS-a (pogledajte dio 3.).
English: Patients should be monitored more closely for signs of toxicities and the dose may need to be further adjusted.
Croatian: Bolesnike treba pažljivije nadzirati zbog mogućih znakova toksičnosti, a možda će biti potrebno dodatno prilagoditi dozu.
English: There are no adequate and well-controlled data from the use of venetoclax in pregnant women.
Croatian: Nema odgovarajućih i dobro kontroliranih podataka o primjeni venetoklaksa u trudnica.
English: Co-administration of CYP3A4 inducers may lead to decreased venetoclax exposure and consequently a risk for lack of efficacy.
Croatian: Istodobna primjena induktora CYP3A4 može smanjiti izloženost venetoklaksu, što za posljedicu ima rizik od nedostatne djelotvornosti.
English: Both B- and T-cells were affected, but the most significant decreases occurred with B-cells.
Croatian: Primijećeni su učinci i na B-stanice i na T-stanice, ali najznačajnija smanjenja zabilježena su kod B-stanica.
English: Kaplan-Meier curves of investigator-assessed PFS from the updated efficacy analysis are shown in Figure 1.
Croatian: Kaplan-Meierove krivulje PFS-a prema ocjeni ispitivača iz analize ažuriranih podataka o djelotvornosti prikazane su na Slici 1.
English: If you take more Venclyxto than you should, talk to your doctor, pharmacist, or nurse or go to hospital immediately.
Croatian: Ako uzmete više lijeka Venclyxto nego što ste trebali, obratite se svom liječniku, ljekarniku ili medicinskoj sestri ili odmah otiđite u bolnicu.
English: You may also include non-alcoholic and non-caffeinated drinks in this amount, but exclude grapefruit, Seville orange, or starfruit (carambola) juices.
Croatian: U tu količinu možete uključiti i bezalkoholne i beskofeinske napitke, ali nemojte piti sokove od grejpa, gorkih naranči ili zvjezdastog voća (karambole).
English: Based on embryo-foetal toxicity studies in animals (see section 5.3), venetoclax may harm the foetus when administered to pregnant women.
Croatian: Prema ispitivanjima embriofetalne toksičnosti na životinjama (vidjeti dio 5.3), venetoklaks može naškoditi plodu kada se primjenjuje u trudnica.
English: Based on population pharmacokinetic analyses, age, sex, and weight do not have an effect on venetoclax clearance.
Croatian: Prema populacijskoj farmakokinetičkoj analizi, dob, spol i tjelesna težina ne utječu na klirens venetoklaksa.
English: The recommended dose of venetoclax in combination with rituximab is 400 mg once daily (see section 5.1 for details of the combination regimen).
Croatian: Preporučena doza venetoklaksa u kombinaciji s rituksimabom je 400 mg jedanput na dan (vidjeti dio 5.1 za informacije o režimu kombiniranog liječenja).
English: TTR, months, median (range)
Croatian: TTR, mjeseci, medijan (raspon)
English: The risk for TLS is in the first 5 weeks of treatment with Venclyxto.
Croatian: Rizik od TLS-a postoji tijekom prvih 5 tjedana liječenja lijekom Venclyxto.
English: Venetoclax had no effect on QTc interval and there was no relationship between venetoclax exposure and change in QTc interval.
Croatian: QTc interval i nije bilo povezanosti između izloženosti venetoklaksu i promjena QTc intervala.
English: Film-coated tablet Multipack: 112 (4 x 28) film-coated tablets
Croatian: Filmom obložena tableta Višestruko pakiranje: 112 (4 x 28) filmom obloženih tableta
English: If a statin (OATP substrate) is used concomitantly with venetoclax, close monitoring of statin-related toxicity is recommended.
Croatian: Ako se statin (supstrat prijenosnika OATP) primjenjuje istodobno s venetoklaksom, preporučuje se pažljivo praćenje toksičnosti izazvane statinom.
English: • a medicine used to prevent organ rejection known as sirolimus
Croatian: • lijek koji se koristi za sprječavanje odbacivanja organa, a zove se sirolimus
English: The next prescribed dose should be taken at the usual time the following day.
Croatian: Sljedeću propisanu dozu treba uzeti sljedeći dan u uobičajeno vrijeme.
English: If you are not sure about this, talk to your doctor, pharmacist or nurse before taking Venclyxto.
Croatian: Ako niste sigurni, razgovarajte sa svojim liječnikom, ljekarnikom ili medicinskom sestrom prije nego uzmete Venclyxto.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Venclyxto in all subsets of the paediatric population in CLL (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Venclyxto u svim podskupinama pedijatrijske populacije za liječenje KLL-a (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: Also inhibitors of P-gp or BCRP may increase venetoclax exposure (see section 4.5).
Croatian: Također, inhibitori P-gp-a ili BCRP-a mogu povećati izloženost venetoklaksu (vidjeti dio 4.5).
English: Toxicities observed in animal studies with venetoclax included dose -dependent reductions in lymphocytes and red blood cell mass.
Croatian: Toksičnosti primijećene u ispitivanjima venetoklaksa na životinjama uključivale su o dozi ovisna smanjenja broja limfocita i mase crvenih krvnih stanica.
English: Intravenous fluids should be administered as indicated based on overall risk of TLS or for those who cannot maintain an adequate level of oral hydration.
Croatian: Intravenske tekućine treba primjenjivati u skladu s indikacijom na temelju ukupnog rizika od TLS-a, kao i u bolesnika koji ne mogu održavati odgovarajuću razinu hidracije peroralnim putem.
English: The safety analysis included patients from one phase 3 study (MURANO), two phase 2 studies (M13-982 and M14-032), and one phase 1 study (M12-175).
Croatian: Analiza sigurnosti obuhvatila je bolesnike iz jednog ispitivanja faze 3 (MURANO), dvaju ispitivanja faze 2 (M13-982 i M14-032) i jednog ispitivanja faze 1 (M12-175).
English: If resolved within 24 to 48 hours of last dose, treatment with venetoclax can be resumed at the same dose.
Croatian: Ako se stanje normalizira unutar 24 do 48 sati nakon posljednje doze, liječenje venetoklaksom može se nastaviti istom dozom.
English: Bendamustine + rituximab N = 195
Croatian: Bendamustin + rituksimab N = 195
English: For events of clinical TLS or blood chemistry changes requiring more than 48 hours to resolve, treatment should be resumed at a reduced dose (see Table 2).
Croatian: U slučaju kliničkog TLS-a ili promjena biokemijskih parametara krvi za čiju je normalizaciju potrebno više od 48 sati, liječenje treba nastaviti smanjenom dozom (vidjeti Tablicu 2).
English: What Venclyxto looks like and contents of the pack
Croatian: Kako Venclyxto izgleda i sadržaj pakiranja
English: Based on findings in animals, Venclyxto may cause male infertility (low or no sperm count).
Croatian: Prema rezultatima ispitivanja na životinjama, moguće je da Venclyxto uzrokuje neplodnost u muškaraca (malen broj ili izostanak spermija).
English: Live vaccines should not be administered during treatment and thereafter until B-cell recovery.
Croatian: Živa cjepiva ne smiju se primjenjivati tijekom liječenja, a ni nakon njega do normalizacije broja B-stanica.
English: • higher level of creatinine
Croatian: • povišene vrijednosti kreatinina
English: Of these, 91 patients had received prior ibrutinib therapy (Arm A) and 36 had received prior idelalisib therapy (Arm B).
Croatian: Među njima je 91 bolesnik prethodno primao terapiju ibrutinibom (skupina A), dok je 36 bolesnika prethodno primalo terapiju idelalisibom (skupina B).
English: Patients received venetoclax via a recommended dose-titration schedule.
Croatian: Bolesnici su primali venetoklaks prema preporučenom rasporedu titracije doze.
English: • low number of white blood cells with fever (febrile neutropenia)
Croatian: • infekcija mokraćnih putova • nizak broj bijelih krvnih stanica praćen vrućicom (febrilna neutropenija)
English: 17p deletion and/or TP53 mutation status ORR, % (95% CI)
Croatian: Status delecije 17p i/ili mutacije gena TP53 ORR, % (95% CI)
English: An additional 51 patients were enrolled in a safety expansion cohort.
Croatian: Dodatno je uključen još 51 bolesnik u proširenu kohortu za ispitivanje sigurnosti.
English: Total (N=127)
Croatian: Ukupno (N=127)
English: Other medicines and Venclyxto
Croatian: Drugi lijekovi i Venclyxto
English: Hospitalisation
Croatian: Hospitalizacija
English: The rates of grade ≥3 laboratory abnormalities relevant to TLS were hyperkalaemia 1%, hyperphosphataemia 1%, and hyperuricaemia 1%.
Croatian: Stopa odstupanja laboratorijskih vrijednosti ≥ 3. stupnja relevantnih za TLS iznosila je 1% za hiperkalijemiju, 1% za hiperfosfatemiju i 1% za hiperuricemiju.
English: Arm B (idelalisib failures) (N=36)
Croatian: Skupina B (bolesnici bez odgovora na idelalisib) (N=36)
English: Once the toxicity has resolved to grade 1 or baseline level (recovery), therapy with venetoclax may be restarted at the same dose.
Croatian: Nakon što se toksičnost ublaži na 1. stupanj ili početnu težinu (oporavak) terapija venetoklaksom može se ponovno započeti istom dozom.
English: The effect of multiple doses of venetoclax up to 1200 mg once daily on the QTc interval was evaluated in an open-label, single-arm study in 176 patients.
Croatian: Učinak višestrukih doza venetoklaksa do 1200 mg jedanput na dan na QTc interval ocjenjivao se u otvorenom ispitivanju s jednom skupinom, provedenom u 176 bolesnika.
English: Take the next dose at the usual time the next day.
Croatian: Uzmite sljedeću dozu sutradan u uobičajeno vrijeme.
English: Women of childbearing potential must use a highly effective method of contraception while taking venetoclax (see section 4.6).
Croatian: Žene reproduktivne dobi moraju koristiti visoko učinkovitu metodu kontracepcije dok uzimaju venetoklaks (vidjeti dio 4.6).
English: All patients had CrCl ≥50 ml/min.
Croatian: CrCl ≥ 50 ml/min.
English: The film-coated tablets are supplied in cartons containing either 7 (in blisters of 1 tablet) or 14 tablets (in blisters of 2 tablets); or a multipack containing 112 tablets (4 x 28 tablets (in blisters of 4 tablets)).
Croatian: Filmom obložene tablete dolaze u kutijama koje sadrže 7 (u blisterima s 1 tabletom) ili 14 tableta (u blisterima s 2 tablete); ili u višestrukom pakiranju koje sadrži 112 tableta (4 x 28 tableta (u blisterima s 4 tablete)).
English: The safety and efficacy of immunisation with live attenuated vaccines during or following venetoclax therapy have not been studied.
Croatian: Sigurnost i djelotvornost cijepljenja živim atenuiranim cjepivima tijekom ili nakon terapije venetoklaksom nisu ispitivane.
English: One patient (ibrutinib failure) achieved complete remission with incomplete marrow recovery.
Croatian: Jedan je bolesnik (koji nije odgovorio na liječenje ibrutinibom) postigao potpunu remisiju uz nepotpun oporavak koštane srži.
English: Both effects were reversible after cessation of dosing with venetoclax, with recovery of lymphocytes occurring 18 weeks post treatment.
Croatian: Oba su učinka bila reverzibilna nakon prestanka primjene venetoklaksa, a broj limfocita vratio se na normalnu vrijednost 18 tjedana nakon liječenja.
English: A dose reduction of at least 50% throughout treatment is recommended for patients with severe hepatic impairment (see section 5.2).
Croatian: Smanjenje doze od najmanje 50% tijekom cijelog trajanja liječenja preporučuje se u bolesnika s teškim oštećenjem jetrene funkcije (vidjeti dio 5.2).
English: • a medicine used to treat heart problems known as digoxin
Croatian: • lijek koji se koristi za liječenje srčanih tegoba, a zove se digoksin
English: Venetoclax + rituximab N = 194
Croatian: Venetoklaks + rituksimab N = 194
English: o When you are receiving Venclyxto therapy alone, you will stay on the 400 mg daily dose, which is the standard dose, for as long as necessary.
Croatian: Ako se budete liječili samo lijekom Venclyxto, nastavit ćete primati dozu od 400 mg na dan, koja je standardna doza, koliko god bude potrebno.
English: All six patients completed the dose titration and reached the recommended daily dose of 400 mg of venetoclax.
Croatian: Svih šest bolesnika dovršilo je titraciju doze i doseglo preporučenu dnevnu dozu od 400 mg venetoklaksa.