FrancophonIA/ELRC3.0 huggingface dataset:
English: They received an average of 3 previous chemotherapy regimens (range 2-11) and 2.6 previous platinum-containing chemotherapies (range 2-8).
Croatian: U prosjeku su prethodno primile 3 kemoterapijska protokola (raspon: 2-11) i 2,6 kemoterapija koje su sadržavale platinu (raspon: 2-8).
English: • digoxin, diltiazem, furosemide, verapamil, valsartan - used to treat heart conditions or high blood pressure
Croatian: • digoksin, diltiazem, furosemid, verapamil, valsartan - koriste se za liječenje srčanih poremećaja ili visokog krvnog tlaka
English: It is unknown whether olaparib or its metabolites are excreted in human milk.
Croatian: Nije poznato izlučuju li se olaparib ili njegovi metaboliti u ljudskom mlijeku.
English: At the time of the PFS analysis, 1 patient had a confirmed partial response with a duration of response of 9.7 months in the olaparib arm.
Croatian: U trenutku provođenja analize PFS-a jedan je bolesnik iz skupine liječene olaparibom imao potvrđen djelomičan odgovor, čije je trajanje iznosilo 9,7 mjeseci.
English: Number of objective responders: Total number of patients with measurable disease (%)
Croatian: Broj bolesnika s objektivnim odgovorom: ukupan broj bolesnika s mjerljivom bolešću (%)
English: Very common side effects that may show up in blood tests:
Croatian: Vrlo česte nuspojave koje mogu biti vidljive u nalazima krvnih pretraga:
English: New metastatic breast cancer (%) Hormone receptor status (%) HR+
Croatian: Status hormonskog receptora (%) HR+
English: In animal studies, no effect on conception was observed but there are adverse effects on embryofoetal survival (see section 5.3).
Croatian: U istraživanjima na životinjama nisu zabilježeni učinci na začeće, ali primijećeni su štetni učinci na preživljenje embrija/fetusa (vidjeti dio 5.3).
English: Lynparza is used for the treatment of a type of ovarian cancer called “BRCA-mutated ovarian cancer”.
Croatian: Lynparza se koristi za liječenje jedne vrste raka jajnika koji se naziva „rak jajnika s mutacijom BRCA gena“.
English: C-olaparib, ~86% of the dosed radioactivity was recovered within a 7-day collection period, ~44% via the urine and ~42% via the faeces.
Croatian: C-olapariba, ~86% primijenjene radioaktivnosti pronađeno je unutar 7-dnevnog razdoblja prikupljanja uzoraka, pri čemu je ~44% radioaktivnosti pronađeno u mokraći, a ~42% u fecesu.
English: The duration of therapy with olaparib in patients who developed MDS/AML varied from <6 months to >2 years; data with longer durations of exposure are limited.
Croatian: Duljina terapije olaparibom u bolesnika u kojih se razvio MDS/AML varirala je od < 6 mjeseci do > 2 godine; podaci s duljom izloženošću su ograničeni.
English: What you need to know before you take Lynparza
Croatian: Što morate znati prije nego počnete uzimati lijek Lynparza
English: A ring-opened piperazin-3-ol moiety, and two mono-oxygenated metabolites (each ~10%) were the major circulating components, with one of the mono-oxygenated metabolites also being the major metabolite in the excreta (6% and 5% of the urinary and faecal radioactivity, respectively).
Croatian: Piperazin-3-ol otvorena prstena i dva mono-oksigenirana metabolita (svaki ~10%) bili su glavne cirkulirajuće komponente, a jedan od dvaju mono-oksigeniranih metabolita bio je i glavni metabolit pronađen u izlučevinama (6% radioaktivnosti pronađeno je u mokraći, a 5% u fecesu).
English: There are no data on retreatment with Lynparza following subsequent relapse (see section 5.1).
Croatian: Ne postoje podaci o ponovnom liječenju lijekom Lynparza nakon idućeg relapsa (vidjeti dio 5.1).
English: Therefore, it is recommended that patients take Lynparza at least one hour after food, and refrain from eating preferably for up to 2 hours afterwards (see section 4.2).
Croatian: Zbog toga se preporuča da bolesnice uzimaju lijek Lynparza najmanje jedan sat nakon obroka, te ne jedu po mogućnosti do 2 sata nakon toga (vidjeti dio 4.2).
English: Lynparza may influence your ability to drive and use machines.
Croatian: Lynparza može utjecati na Vašu sposobnost upravljanja vozilima i rada sa strojevima.
English: In vitro, olaparib produced little/no inhibition of UGT1A4, UGT1A9, UGT2B7, or CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6 or 2E1 and is not expected to be a clinically significant time dependent inhibitor of any of these CYP enzymes.
Croatian: In vitro je olaparib neznatno inhibirao ili nije inhibirao UGT1A4, UGT1A9, UGT2B7 ni CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6 i 2E1 pa se ne očekuje da bi mogao djelovati kao klinički značajan i o vremenu ovisan inhibitor nekoga od tih CYP enzima.
English: Data demonstrating clinical validation of tumour BRCA1/2 tests in breast cancer are not currently available.
Croatian: Podaci koji dokazuju kliničku validaciju testova tumorskih mutacija gena BRCA1/2 kod raka dojke trenutno nisu dostupni.
English: Studies in animals have shown reproductive toxicity including serious teratogenic effects and effects on embryofoetal survival in the rat at maternal systemic exposures lower than those in humans at therapeutic doses (see section 5.3).
Croatian: Istraživanja na životinjama pokazala su reproduktivnu toksičnost uključujući ozbiljne teratogene učinke i učinke na embriofetalno preživljavanje kod štakora pri razinama sistemske izloženosti ženki manjima od onih koje se postižu kod ljudi nakon primjene terapijskih doza (vidjeti dio 5.3).
English: It cannot be excluded that olaparib may increase the exposure to substrates of BCRP (e.g. methotrexate, rosuvastatin), OATP1B1 (e.g. bosentan, glibenclamide, repaglinide, statins and valsartan), OCT1 (e.g. metformin), OCT2 (e.g. serum creatinine), OAT3 (e.g. furosemide and methotrexate), MATE1 (e.g. metformin) and MATE2K (e.g. metformin).
Croatian: Ne može se isključiti mogućnost da bi olaparib mogao povećati izloženost supstratima BRCP-a (npr. metotreksat, rosuvastatin), OATP1B1 (npr. bosentanu, glibenklamidu, repaglinidu, statinima i valsartanu), OCT1 (npr. metforminu), OCT2 (npr. serumskom kreatininu), OAT3 (npr. furosemidu i metotreksatu), MATE1 (npr. metforminu) i MATE2K (npr. metforminu).
English: No previous treatment with a PARP inhibitor, including olaparib, was permitted.
Croatian: Nije bilo dopušteno prethodno liječenje inhibitorom PARP-a, uključujući olaparib.
English: What Lynparza contains The active substance is olaparib.
Croatian: Što Lynparza sadrži Djelatna tvar je olaparib.
English: Do not switch to Lynparza capsules unless your doctor tells you
Croatian: Ne smijete početi uzimati Lynparza kapsule ako Vam to nije rekao Vaš liječnik.
English: Anaemia was managed with dose interruptions and dose reductions (see section 4.2), and where appropriate with blood transfusions.
Croatian: Zbrinjavanje anemije obuhvaćalo je privremeni prekid doziranja i smanjenje doze (vidjeti dio 4.2), i gdje je bilo potrebno transfuzije krvi.
English: In the event of an overdose, physicians should follow general supportive measures and should treat the patient symptomatically.
Croatian: U slučaju predoziranja, liječnici se trebaju pridržavati općih suportivnih mjera i liječiti bolesnika simptomatski.
English: • The doses of Lynparza tablets and capsules are not the same.
Croatian: • Doze Lynparza tableta i kapsula nisu iste.
English: • you have problems with your kidneys.
Croatian: • ako imate bubrežnih tegoba.
English: Combination of olaparib with vaccines or immunosuppressant agents has not been studied.
Croatian: Kombinacija olapariba s cjepivima ili imunosupresivnim lijekovima nije ispitivana.
English: The efficacy of some hormonal contraceptives may be reduced if co-administered with olaparib (see also sections 4.4 and 4.6).
Croatian: Djelotvornost nekih hormonskih kontraceptiva može biti smanjena pri istodobnoj primjeni s olaparibom (vidjeti i dijelove 4.4 i 4.6).
English: The duration of therapy with olaparib in patients who developed MDS/AML varied from < 6 months to > 2 years.
Croatian: Duljina terapije olaparibom u bolesnica u kojih se razvio MDS/AML varirala je od < 6 mjeseci do > 2 godine.
English: • ergot alkaloids - used to treat migraines and headaches
Croatian: • ergot-alkaloidi - koriste se za liječenje migrena i glavobolja
English: • feeling tired or weak
Croatian: • umor ili slabost
English: Lynparza may only be used in patients with severe renal impairment if the benefit outweighs the potential risk, and the patient should be carefully monitored for renal function and adverse events.
Croatian: Lynparza se smije koristiti u bolesnika s teškim oštećenjem bubrežne funkcije samo ako korist nadmašuje mogući rizik, a tada treba pažljivo nadzirati bubrežnu funkciju bolesnika i mogući nastup štetnih događaja.
English: Exploratory analyses of time to first subsequent therapy or death (TFST) and time to second subsequent therapy or death (TSST- an approximation of PFS2) were also performed.
Croatian: Provedene su i eksploracijske analize vremena do prve sljedeće terapije ili smrti (engl. time to first subsequent therapy or death, TFST) i vremena do druge sljedeće terapije ili smrti (engl. second subsequent therapy or death, TSST - približna vrijednost PFS2).
English: • bosentan - used to treat pulmonary artery hypertension
Croatian: • bosentan - koristi se za liječenje plućne arterijske hipertenzije
English: If you are not sure, talk to your doctor, pharmacist or nurse before taking Lynparza.
Croatian: Ako niste sigurni, razgovarajte sa svojim liječnikom, ljekarnikom ili medicinskom sestrom prije nego uzmete lijek Lynparza.
English: A small number of patients treated with Lynparza reported inflammation of the lungs (pneumonitis).
Croatian: Malen broj bolesnica liječenih lijekom Lynparza prijavilo je upalu pluća (pneumonitis).
English: Seven patients, all stage IV, had no cytoreductive surgery.
Croatian: Sedam bolesnica, koje su sve imale bolest stadija IV, nije podvrgnuto citoredukciji.
English: • rash or itchy rash on swollen, reddened skin (dermatitis)
Croatian: • osip ili osip koji svrbi na natečenoj, crvenoj koži (dermatitis)
English: The study demonstrated a clinically relevant and statistically significant improvement in investigator assessed PFS for olaparib compared to placebo.
Croatian: Ispitivanje je pokazalo klinički važno i statistički značajno poboljšanje PFS-a prema ocjeni ispitivača kod primjene olapariba u odnosu na placebo.
English: On multiple dosing there is no marked accumulation, with steady state exposures achieved within ~3 to 4 days.
Croatian: Nakon primjene višekratnih doza nije primijećena značajna kumulacija, a izloženost u stanju dinamičke ravnoteže postiže se unutar ~3 do 4 dana.
English: A pregnancy test should be performed on all women of childbearing potential prior to treatment and considered regularly throughout treatment.
Croatian: Kod svih žena reproduktivne dobi treba provesti test za trudnoću prije početka liječenja te razmotriti njegovo redovito provođenje tijekom cijelog liječenja.
English: In vitro, CYP3A4/5 were shown to be the enzymes primarily responsible for the metabolism of olaparib (see section 4.5).
Croatian: Pokazalo se da su in vitro CYP3A4/5 glavni enzimi odgovorni za metabolizam olapariba (vidjeti dio 4.5).
English: Patients should have previously been treated with an anthracycline and a taxane in the (neo)adjuvant or metastatic setting unless patients were not suitable for these treatments (see section 5.1).
Croatian: Bolesnici su morali prethodno biti liječeni antraciklinom i taksanom u sklopu (neo)adjuvantne terapije ili terapije za metastatsku bolest, osim ako su bili nepogodni za takvo liječenje (vidjeti dio 5.1).
English: The active substance is olaparib.
Croatian: Djelatna tvar je olaparib.
English: In BRCA-mutated patients (n=136) there was a statistically significant improvement in PFS, TFST and TSST.
Croatian: U bolesnica s mutacijom BRCA gena (n=136) zabilježeno je statistički značajno poboljšanje PFS-a, TFST-a i TSST-a.
English: In the olaparib-treated group, 28.4% of patients remained on treatment for ≥2 years and 14.9% for ≥5 years.
Croatian: U skupini liječenoj olaparibom 28,4% bolesnica nastavilo je liječenje tijekom ≥ 2 godine, dok se njih 14,9% liječilo ≥ 5 godina.
English: * There was no strategy for multiple testing in place for the sub-group analyses.
Croatian: *Nije postojala strategija za višestruko testiranje u analizama podskupina.
English: Studies using human bone marrow cells also showed that direct exposure to olaparib can result in toxicity to bone marrow cells in ex vivo assays.
Croatian: Ispitivanja na stanicama ljudske koštane srži također su pokazala da direktna izloženost olaparibu može uzrokovati toksičnost na stanice koštane srži u ex vivo testovima.
English: Of the 94 patients on the placebo arm who received subsequent therapy, 49 (52%) received a PARP inhibitor.
Croatian: Od 94 bolesnice iz skupine koja je primala placebo, a koje su naknadno primile sljedeću terapiju, njih 49 (52%) primilo je inhibitor PARP-a.
English: There was no strategy for multiple testing in place for the sub-group analyses or for the all patients TFST.
Croatian: Nije postojala strategija za višestruko testiranje za analize podskupina niti za TFST kod svih bolesnica.
English: Myelodysplastic syndrome/Acute myeloid leukaemia The overall incidence of myelodysplastic syndrome/acute myeloid leukaemia (MDS/AML) in patients treated in clinical trials with Lynparza monotherapy, including long-term survival follow-up, was <1.5% and the majority of events had a fatal outcome.
Croatian: Mijelodisplastični sindrom/akutna mijeloična leukemija Ukupna incidencija mijelodisplastičnog sindroma/akutne mijeloične leukemije (MDS/AML) kod bolesnika koji su primali monoterapiju lijekom Lynparza u kliničkim ispitivanjima, uključujući dugoročno praćenje preživljenja, iznosila je < 1,5%, a većina događaja imala je smrtni ishod.
English: Based on its mechanism of action (PARP inhibition), Lynparza could cause foetal harm when administered to a pregnant woman.
Croatian: S obzirom na mehanizam djelovanja (inhibicija poli (ADP-riboza) polimeraze [PARP]), Lynparza može naškoditi plodu ako se primjenjuje kod trudnica.
English: All patients had received first-line platinum-based therapy.
Croatian: Sve su bolesnice prethodno primile prvolinijsku terapiju utemeljenu na platini.
English: • low white blood cell count (lymphopenia) which may decrease your ability to fight infection and may be associated with fever
Croatian: • nizak broj bijelih krvnih stanica (limfopenija), koji može smanjiti sposobnost tijela da se bori protiv infekcije, a može biti praćen vrućicom
English: • Taking the wrong dose or a capsule instead of a tablet could lead to Lynparza not working properly or to more side effects.
Croatian: • Uzimanje pogrešne doze ili kapsule umjesto tablete može dovesti do toga da Lynparza ne djeluje kako bi trebala ili uzrokovati više nuspojava.
English: In solutions of purified proteins, the olaparib fraction bound to albumin was approximately 56%, which was independent of olaparib concentrations.
Croatian: Udio olapariba vezanog za albumin u otopinama pročišćenih proteina iznosio je približno 56% i nije ovisio o koncentracijama olapariba.
English: Enrolment did not require evidence of BRCA1/2 mutation (BRCA mutation status for some patients was determined retrospectively).
Croatian: Za uključivanje nije bio potreban dokaz o mutaciji BRCA1/2 gena (status BRCA mutacije za neke bolesnice određen je retrospektivno).
English: There are no animal studies on the excretion of olaparib in breast milk.
Croatian: Ne postoje ispitivanja na životinjama o izlučivanju olapariba u majčino mlijeko.
English: These findings occurred at exposures below those seen clinically.
Croatian: Ti su nalazi primijećeni kod izloženosti manjih od kliničkih.
English: PARPs are required for the efficient repair of DNA single strand breaks and an important aspect of PARP-induced repair requires that after chromatin modification, PARP auto-modifies itself and dissociates from the DNA to facilitate access for base excision repair (BER) enzymes.
Croatian: PARP je neophodan za učinkovit popravak jednolančanih lomova DNK, a važan aspekt popravka potaknutog djelovanjem PARP-a iziskuje da se nakon modifikacije kromatina PARP samostalno modificira i odvoji od DNK kako bi olakšao pristup enzimima koji popravljaju DNK izrezivanjem oštećene baze (engl. base excision repair, BER).
English: • low white blood cell count (leukopenia or neutropenia) which may decrease your ability to fight infection and may be associated with fever.
Croatian: • nizak broj bijelih krvnih stanica (leukopenija i neutropenija), koji može smanjiti sposobnost tijela da se bori protiv infekcije, a može biti praćen vrućicom
English: Using the same assay, the fraction bound to alpha-1 acid glycoprotein was 29% at 10 µg/mL with a trend of decreased binding at higher concentrations.
Croatian: U istom je testu udio vezan za alfa-1-kiseli glikoprotein pri koncentraciji od 10 μg/ml iznosio 29%, uz trend smanjenog vezivanja pri višim koncentracijama.
English: Patients should start treatment with Lynparza no later than 8 weeks after completion of their final dose of the platinum-containing regimen.
Croatian: Bolesnice bi trebale započeti liječenje lijekom Lynparza najkasnije 8 tjedana nakon završetka posljednje doze u sklopu protokola koji sadrži platinu.
English: Patients who had been treated with bevacizumab were excluded from the study, therefore there are no safety and efficacy data on olaparib patients who had previously received bevacizumab.
Croatian: Budući da u ispitivanju nisu mogle sudjelovati bolesnice koje su prethodno bile liječene bevacizumabom, nema podataka o sigurnosti i djelotvornosti olapariba kod bolesnica koje su prethodno primale bevacizumab.
English: Patients were stratified by response to first-line platinum chemotherapy; complete response (CR) or partial response (PR).
Croatian: Bolesnice su bile stratificirane prema odgovoru na prvu liniju kemoterapije utemeljene na platini: potpun odgovor (engl. complete response, CR) ili djelomičan odgovor (engl. partial response, PR).
English: Tell your doctor, pharmacist or nurse if you are taking or are planning to take any of the following medicines:
Croatian: Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako uzimate ili planirate uzeti neki od sljedećih lijekova:
English: If you forget to take Lynparza, take your next normal dose at its scheduled time.
Croatian: Ako ste zaboravili uzeti lijek Lynparza, uzmite sljedeću uobičajenu dozu prema predviđenom rasporedu.
English: • Taking the wrong dose or a tablet instead of a capsule could lead to Lynparza not working properly or to more side effects.
Croatian: • Uzimanje pogrešne doze ili tablete umjesto kapsule može dovesti do toga da Lynparza ne djeluje kako bi trebala ili uzrokovati više nuspojava.
English: Many had also received other DNA damaging agents and radiotherapy.
Croatian: Mnogi od njih primali su i druge lijekove i radioterapiju koji oštećuju DNK.
English: Ovarian cancer was the primary tumour in >80% of the patients.
Croatian: Karcinom jajnika bio je primarni tumor u > 80% bolesnica.
English: • dabigatran - used to thin the blood
Croatian: • dabigatran - koristi se za razrjeđivanje krvi
English: • The doses of Lynparza capsules and tablets are not the same.
Croatian: • Doze Lynparza kapsula i tableta nisu iste.
English: Induction of CYP1A2, 2B6 and 3A4 has been shown in vitro with CYP2B6 being most likely to be induced to a clinically relevant extent.
Croatian: Indukcija CYP1A2, 2B6 i 3A4 pokazana je in vitro, od čega je najvjerojatnije za indukciju CYP2B6 da je u klinički značajnim razmjerima.
English: PFS (63% maturity)
Croatian: PFS (zrelost podataka: 63%)
English: Median age was 59 years in both arms.
Croatian: Medijan dobi u obje skupine bio je 59 godina.
English: Lynparza has moderate influence on the ability to drive and use machines.
Croatian: Lynparza ima umjeren utjecaj na na sposobnost upravljanja vozilima i rada sa strojevima.
English: Reports of pneumonitis had no consistent clinical pattern and were confounded by a number of pre-disposing factors (cancer and/or metastases in lungs, underlying pulmonary disease, smoking history, and/or previous chemotherapy and radiotherapy).
Croatian: Prijavljeni slučajevi pneumonitisa nisu imali dosljedan klinički uzorak, a njegovu je dijagnozu otežavao niz predisponirajućih faktora (karcinom i/ili metastaze u plućima, podležeća plućna bolest, pušenje u anamnezi i/ili prethodna kemoterapija i radioterapija).
English: • itraconazole, fluconazole - used for fungal infections
Croatian: • itrakonazol, flukonazol - koristi se za liječenje gljivičnih infekcija
English: Do not use this medicine after the expiry date which is stated on the carton and the bottle after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i boci iza oznake „EXP“.
English: By central germline testing, deleterious or suspected deleterious mutations were identified in 95.3% (365/383) and 4.7% (18/383) of patients, respectively.
Croatian: Centralnim su testiranjem na germinativne mutacije kod 95,3% (365/383) bolesnica utvrđene štetne mutacije, a kod njih 4,7% (18/383) suspektne štetne mutacije.
English: In vitro, human plasma protein binding of olaparib was dose-dependent; the fraction bound was approximately 91% at 1 µg/mL, reducing to 82% at 10 µg/mL and to 70% at 40 µg/mL.
Croatian: Vezivanje olapariba za proteine u plazmi ljudi in vitro ovisilo je o dozi; vezani udio iznosio je približno 91% pri koncentraciji od 1 μg/ml, a smanjio se na 82% pri 10 μg/ml te 70% pri 40 μg/ml.
English: The incidence of elevations in mean corpuscular volume from low or normal at baseline to above the ULN was approximately 55%.
Croatian: Incidencija povećanja prosječnog volumena eritrocita od malog ili normalnog na početku ispitivanja do iznad GGN-a iznosila je približno 55%.
English: If the blood parameters remain clinically abnormal after 4 weeks of Lynparza dose interruption, bone marrow analysis and/or blood cytogenetic analysis are recommended.
Croatian: Ako krvni parametri odstupaju od normalnih kliničkih vrijednosti i nakon 4 tjedna privremenog prekida primjene lijeka Lynparza, preporučuje se provesti analizu koštane srži i/ili citogenetsku analizu krvi.
English: No significant interaction was observed with anastrozole or letrozole whereas tamoxifen decreased exposure to olaparib by 27%.
Croatian: Nije zapažena značajna interakcija s anastrozolom ili letrozolom dok je tamoksifen smanjio izloženost olaparibu za 27%.
English: When dosed orally to rats, olaparib induced micronuclei in bone marrow.
Croatian: Nakon peroralne primjene u štakora, olaparib je inducirao stvaranje mikronukleusa u koštanoj srži.
English: This is because Lynparza can affect the way some other medicines work.
Croatian: Naime, Lynparza može utjecati na način djelovanja nekih drugih lijekova.
English: No significant interaction was observed with anastrozole or letrozole, whereas tamoxifen decreased exposure to olaparib by 27%.
Croatian: Nije zapažena značajna interakacija s anastrozolom ili letrozolom, dok je tamoksifen smanjio izloženost olaparibu za 27%.
English: Do not drink grapefruit juice while you are being treated with Lynparza.
Croatian: Lynparza s pićem Nemojte piti sok od grejpa dok se liječite lijekom Lynparza.
English: • It is not known whether Lynparza passes into breast milk.
Croatian: • Nije poznato izlučuje li se Lynparza u majčino mlijeko.
English: Dose interruptions and reductions occurred most frequently in the first 3 months of treatment.
Croatian: Privremeni prekid doziranja i smanjenje doze pojavili su se najčešće u prva tri mjeseca.
English: Common side effects that may show up in blood tests:
Croatian: Česte nuspojave koje mogu biti vidljive u nalazima krvnih pretraga:
English: • telithromycin, clarithromycin, erythromycin - used for bacterial infections
Croatian: • telitromicin, klaritromicin, eritromicin - koriste se za liječenje bakterijskih infekcija
English: Median time to first onset of anaemia was approximately 4 weeks (approximately 7 weeks for CTCAE grade ≥ 3 events).
Croatian: Medijan vremena do prve pojave anemije bio je otprilike 4 tjedna (otprilike 7 tjedana za CTCAE stupanj ≥ 3).