FrancophonIA/ELRC3.0 huggingface dataset:
English: Table 7 Treatment regimens in study NO16966 (mCRC)
Croatian: Tablica 7 Protokoli liječenja u ispitivanju NO16966 (mCRC)
English: Do not give Capecitabine Accord to children and adolescent.
Croatian: Kapecitabin Accord nemojte davati djeci i adolescentima.
English: Finally, β-ureido-propionase cleaves FUPA to α-fluoro-β-alanine (FBAL) which is cleared in the urine.
Croatian: Na kraju, β-ureido-propionaza cijepa FUPA do α-fluoro-βalanina (FBAL) koji se izlučuje urinom.
English: • sleeplessness (insomnia), depression
Croatian: • nesanica (insomnija), depresij
English: In animal studies effects on fertility were observed (see section 5.3)
Croatian: U studijama na životinjama utjecaj na plodnost je zabilježen (vidjeti dio 5.3)
English: - The active substance is capecitabine.
Croatian: - Djelatna tvar je kapecitabin.
English: • specific changes in the electrocardiogram (QT prolongation)
Croatian: • specifične promjene u elektrokardiogramu (produljenje QT intervala)
English: Your doctor may instruct you to restart treatment at a lower dose.
Croatian: Liječnik će vam možda savjetovati da ponovno počnete liječenje manjom dozom.
English: • if you previously have had severe reactions to fluoropyrimidine therapy (a group of anticancer medicines such as fluorouracil),
Croatian: • ako ste ranije imali teške reakcije na terapiju fluoropirimidinima (skupinu antikancerogenih lijekova kao što je fluorouracil)
English: Also contains lactose, see the package leaflet for further information.
Croatian: Također sadrži laktozu, vidjeti Uputu o lijeku za dodatne informacije.
English: Previous therapy should have included an anthracycline.
Croatian: Ranija terapija trebala je uključivati antraciklin.
English: Other than warfarin, no formal interaction studies between capecitabine and other CYP2C9 substrates have been conducted.
Croatian: Osim s varfarinom, nikakve formalne studije interakcije između kapecitabina i drugih CYP2C9
English: • jaundice (yellowing of skin and eyes)
Croatian: • žutica (žutilo kože i očiju)
English: North Harrow, Middx HA1 4HF
Croatian: North Harrow, Middx HA1 4HF Ujedinjeno Kraljevstvo
English: Progression-free Survival after 6 months
Croatian: Preživljenje bez progresije bolesti nakon 6 mjeseci ITT
English: Furthermore, Capecitabine Accord is used to prevent new occurrence of colon cancer after complete removal of the tumour by surgery.
Croatian: Nadalje, Kapecitabin Accord se koristi kako bi se spriječila pojava novog karcinoma debelog crijeva nakon što je tumor u potpunosti kirurški uklonjen.
English: Contact your doctor immediately if you are concerned about any of the side effects or if you notice any additional side effects not listed in the leaflet (see section 4 Possible side effects.
Croatian: Odmah se javite svim liječniku ako ste zabrinuti zbog neke od nuspojava ili ako primijetite dodatne nuspojave koje nisu navedene u ovoj uputi o lijeku (pogledajte dio 4 Moguće nuspojave).
English: The capecitabine pivotal studies included females of childbearing potential and males only if they agreed to use an acceptable method of birth control to avoid pregnancy for the duration of the study and for a reasonable period thereafter.
Croatian: Pivotalne studije kapecitabina uključivale su žene reproduktivne dobi i muškarce samo ako su se složili da koriste prihvatljivu metodu kontracepcije kako bi izbjegli trudnoću za vrijeme trajanja studije i razuman period poslije.
English: • hiccups, change in voice
Croatian: • štucanje, promjene glasa
English: • Chest pain: if you experience pain localised to the centre of the chest, especially if it occurs during exercise.
Croatian: • bol u prsima: ako osjetite bol u sredini prsnog koša, osobito ako se pojavi tijekom vježbanja.
English: • It is important that you take all your medicine as prescribed by your doctor.
Croatian: • Važno je da lijek uzimate na način koji Vam je propisao liječnik.
English: • have severe skin reaction
Croatian: • imate tešku kožnu reakciju.
English: You should take Capecitabine Accord no later than 30 minutes after meals.
Croatian: Kapecitabin Accord uzmite najkasnije 30 minuta nakon jela.
English: Capecitabine Accord is not indicated in children and adolescent.
Croatian: Kapecitabin Accord nije indiciran u djece i adolescenata.
English: What you need to know before you take Capecitabine Accord Do not take Capecitabine Accord
Croatian: Što morate znati prije nego počnete uzimati Kapecitabin Accord Nemojte uzimati Kapecitabin Accord
English: The following headings are used to rank the ADRs by frequency: very common (≥ 1/10), common (≥ 1/100 to < 1/10) uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000) and very rare (< 1/10,000).
Croatian: (≥ 1/100 do < 1/10) , manje često (≥ 1/1000 do < 1/100), rijetko (≥ 1/10 000 do < 1/1000) i vrlo rijetko (< 1/10 000).
English: Capecitabine Accord is indicated for the treatment of:
Croatian: Kapecitabin Accord je indiciran za liječenje:
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, pyrimidine analogues, ATC code: L01BC06
Croatian: Farmakoterapijska skupina: antineoplastici, antimetaboliti, analozi pirimidina, ATK oznaka: L01BC06
English: • Medicines used to treat folic acid deficiency.
Croatian: • lijekove za liječenje nedostatka folatne kiseline.
English: Food interaction
Croatian: Interakcije s hranom:
English: Capecitabine Accord belongs to the group of medicines called "cytostatic medicines", which stop the growth of cancer cells.
Croatian: Kapecitabin Accord pripada skupini lijekova pod nazivom "citostatici", koji zaustavljaju rast stanica raka.
English: Cytochrome P-450 2C9 substrates
Croatian: Supstrati citokroma P-450 2C9
English: Other medicines and Capecitabine Accord
Croatian: Drugi lijekovi i Kapecitabin Accord
English: • have imbalances of ions in your blood (electrolyte imbalances, seen in test)
Croatian: • imate neravnotežu iona u krvi (neravnoteža elektrolita vidljiva u nalazima)
English: Accord Healthcare Limited, Sage house, 319 Pinner Road, Harrow HA1 4HF, United Kingdom
Croatian: Accord Healthcare Limited, Sage house, 319 Pinner Road, North Harrow,
English: For terms marked with a “+”, the frequency count was based on grade 3-4 ADRs.
Croatian: Za pojmove označene s „+“učestalost se temeljila na nuspojavama 3.-4. stupnja.
English: • certain types of arrhythmias (including ventricular fibrillation, torsade de pointes, and bradycardia)
Croatian: • određene vrste aritmija (uključujući ventrikularnu fibrilaciju, torsade de pointes i bradikardiju)
English: Care should be exercised when capecitabine is co-administered with 2C9 substrates (e.g., phenytoin).
Croatian: Kapecitabin se treba pažljivo davati kada se primjenjuje zajedno s 2C9 supstratima (npr. fenitoinom).
English: Capecitabine Accord tablets are usually taken for 14 days followed by a 7 day rest period (when no tablets are taken).
Croatian: Kapecitabin Accord se preporučuje uzimati 14 dana, nakon čega slijedi 7 dana pauze (bez uzimanja tableta).
English: PRIMARY ANALYSIS XELOX/ XELOX+P/ XELOX+BV (EPP*: N=967; ITT**: N=1017)
Croatian: PRIMARNA ANALIZA XELOX/ XELOX+P/ XELOX+BV (EPP*: N=967; ITT**: N=1017)
English: Careful monitoring of patients ≥60 years of age is advisable.
Croatian: Savjetuje se pažljivo praćenje bolesnika u dobi od ≥60 godina.
English: The dose of Capecitabine Accord is based on your body surface area.
Croatian: Doza Kapecitabina Accord ovisi o Vašoj tjelesnoj površini, a izračunava se na temelju
English: See also interaction with coumarin-derivative anticoagulants below, and section 4.4.
Croatian: Vidjeti dolje interakcije s kumarinskim antikoagulansima i dio 4.4.
English: These results suggest an interaction, probably due to an inhibition of the cytochrome P450 2C9 isoenzyme system by capecitabine.
Croatian: Ovi rezultati upućuju na interakciju koja je vjerojatno posljedica inhibicije izoenzimskog sustava citokroma P450 2C9 kapecitabinom.
English: • problems with liver function (seen in blood tests) and increased blood bilirubin (excreted by the liver)
Croatian: • problemi s funkcijom jetre (na rezultatima nalaza krvi) i povišen bilirubin u krvi (koji se izlučuje iz jetre)
English: Your doctor will prescribe a dose and treatment regimen that is right for you.
Croatian: Liječnik će Vam propisati dozu i način primjene koji je najučinkovitiji za Vas.
English: cisplatin, irinotecan)
Croatian: bevacizumab, cisplatin, irinotekan).
English: Parameter: Overall Survival
Croatian: Parametar: ukupno preživljenje
English: • pain or altered/abnormal sensation in the mouth, pain in the jaw
Croatian: • bol ili izmijenjen/abnormalan osjećaj u ustima, bol u čeljusti
English: Capecitabine dose reduction decreases systemic exposure to 5-FU more than dose-proportionally, due to non-linear pharmacokinetics for the active metabolite.
Croatian: Smanjenje doze kapecitabina smanjuje sistemnu izloženost 5-FU-u više nego proporcionalno dozi zbog nelinearne farmakokinetike aktivnoga metabolita.
English: The usual dose for adults is 1250 mg/m2 of body surface area taken two times daily (morning and evening).
Croatian: Uobičajena doza za odrasle iznosi 1250 mg/m2 tjelesne površine koja se uzima dvaput dnevno (ujutro i navečer).
English: • lumps under the skin (lipoma)
Croatian: • kvržice ispod kože (lipom)
English: Caution must be exercised in patients with diabetes mellitus or electrolyte disturbances, as these may be aggravated during capecitabine treatment.
Croatian: Pozornost se mora obratiti na bolesnike sa šećernom bolešću ili poremećajem elektrolita koji se mogu pogoršati tijekom liječenja kapecitabinom.
English: How to store Capecitabine Accord Contents of the pack and other information
Croatian: Kako čuvati Kapecitabin Accord Sadržaj pakiranja i dodatne informacije
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da bi mogli biti trudni ili planirate imati dijete, obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek.Kapecitabin Accord ne smijete uzimati ako ste trudni ili mislite da ste trudni.
English: • difficulty in urination, blood or protein in the urine
Croatian: • poteškoće pri mokrenju, krv ili proteini u mokraći
English: The European Medicines Agency has waived the obligation to submit the results of studies with the reference medicinal product containing capecitabine in all subsets of the paediatric population in adenocarcinoma of the colon and rectum, gastric adenocarcinoma and breast carcinoma (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je izuzela obvezu podnošenja rezultata ispitivanja za referentni lijek koji sadrži kapecitabin u svim podskupinama pedijatrijske populacije u indikacijama adenokarcinoma kolona i rektuma, adenokarcinoma želuca i karcinoma dojke (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: • DPD Deficiency: if you have a known DPD deficiency, you are at an increased risk of acute early-onset of toxicity and severe, life-threatening, or fatal adverse reactions caused by Capecitabine Accord (e.g. stomatitis, mucosal inflammation, diarrhoea, neutropenia, and neurotoxicity).
Croatian: • Nedostatak DPD-a: Ako imate nedostatak DPD-a, imate povećan rizik od akutnog ranog nastupa toksičnosti i teških, po život opasnih ili smrtonosnih nuspojava koje uzrokuje Kapecitabin Accord (npr. stomatitis, upala sluznica, proljev, neutropenija i neurotoksičnost).
English: • decreases in the number of white blood cells or red blood cells (seen in tests)
Croatian: • smanjenje broja bijelih krvnih stanica ili crvenih krvnih stanica (uočeno u nalazima)
English: Dehydration may cause acute renal failure, especially in patients with pre-existing compromised renal function or when capecitabine is given concomitantly with known nephrotoxic drugs.
Croatian: Dehidracija može izazvati akutno zatajenje bubrega, osobito u bolesnika s otprije kompromitiranom bubrežnom funkcijom ili kada se kapecitabin daje istodobno s poznatim nefrotoksičnim lijekovima.
English: • cannot keep your food or water in your body because of severe nausea and vomiting
Croatian: • imate šećernu bolest • možete zadržati hranu ili vodu u vašem tijelu usljed jake mučnine ili povraćanja
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Croatian: Ako vam je liječnik rekao da ne podnosite neke vrste šećera, obratite mu se prije uzimanja ovog lijeka.
English: In a interaction study with single-dose warfarin administration, there was a significant increase in the mean AUC (+57%) of S-warfarin.
Croatian: Tijekom ispitivanja interakcije s jednokratnom dozom varfarina uočeno je znatno povećanje površine ispod krivulje (AUC) (+57%) S-varfarina.
English: Sage House
Croatian: SageHouse
English: • have or had heart problems (for example an irregular heart beat) or pains to the chest, jaw and back, brought on by physical effort and due to problems with the blood flow to the heart
Croatian: • imate ili ste imali srčane probleme (na primjer nepravilan rad srca) ili bolove u prsima, čeljusti i leđima, koji se javljaju uslijed fizičkog napora, a zbog problema s protokom krvi do srca
English: Interrupt until resolved to grade 0-1 75%
Croatian: • Stupanj 3 -1. pojavljivanje Prekinuti dok se ne svede na stupanj 0-1 75% -2. pojavljivanje
English: Method of administration Capecitabine Accord tablets should be swallowed with water within 30 minutes after a meal.
Croatian: Kapecitabin Accord filmom obložene tablete moraju se progutati s vodom unutar 30 minuta nakon obroka.
English: • if you have severely low levels of white cells or platelets in the blood (leucopenia, neutropenia or thrombocytopenia)
Croatian: • ako imate izrazito nisku razinu bijelih krvnih stanica ili trombocita u krvi (leukopenija, neutropenija ili trombocitopenija)
English: Elderly: Based on the population pharmacokinetic analysis, which included patients with a wide range of ages (27 to 86 years) and included 234 (46%) patients greater or equal to 65, age has no influence on the pharmacokinetics of 5'-DFUR and 5-FU.
Croatian: Starije osobe: na temelju rezultata populacijske farmakokinetske analize, koja je uključivala bolesnike širokoga dobnog raspona (od 27 do 86 godina) te 234 (46%) bolesnika od 65 godina ili starijih, ustanovljeno je da dob nema utjecaja na farmakokinetiku 5'-DFUR i 5-FU.
English: At the beginning of a treatment cycle, if a treatment delay is indicated for either capecitabine or the other medicinal product(s), then administration of all therapy should be delayed until the requirements for restarting all medicinal products are met.
Croatian: Ako je na početku ciklusa liječenja indicirana odgoda liječenja bilo kapecitabinom, bilo drugim lijekom (lijekovima), primjena svih lijekova mora se odgoditi dok ne budu zadovoljeni uvjeti za početak liječenja svim lijekovima.
English: Careful monitoring and prompt treatment interruption is recommended if the patient develops a grade 2, 3 or 4 adverse event during treatment and subsequent dose adjustment as outlined in Table 3 above.
Croatian: Pažljivo praćenje i odgovarajući prekid liječenja preporučuju se u slučaju bolesnika koji razviju nuspojave 2., 3. ili 4. stupnja tijekom liječenja, nakon čega slijedi prilagodba daljnjih doza kako je navedeno u Tablici
English: Discontinue treatment permanently
Croatian: -3. pojavljivanje Liječenje trajno obustaviti
English: Capecitabine Accord contains lactose
Croatian: Kapecitabin Accord sadrži laktozu
English: • infections of the lungs or respiratory tract system (e.g. pneumonia or bronchitis)
Croatian: • infekcije pluća ili dišnih puteva (npr. upala pluća ili bronhitis)
English: Two examples are provided here: A person whose body weight is 64 kg and height is 1.64 m has a body surface area of 1.7 m2 and should take 4 tablets of 500 mg and 1 tablet of 150 mg two times daily.
Croatian: Ovdje su navedena dva primjera: osoba čija tjelesna težina iznosi 64 kg, a visina 1,64 m ima tjelesnu površinu od 1,7 m2 te mora uzimati 4 tablete od 500 mg i 1 tabletu od 150 mg dvaput dnevno.
English: If unscheduled laboratory assessments during a treatment cycle show that the neutrophil count drops below 1.0 x 109/L or that the platelet count drops below 75 x 109/L, treatment with capecitabine should be interrupted.
Croatian: Ako neplanirane laboratorijske pretrage tijekom ciklusa liječenja pokažu pad broja neutrofila ispod 1,0 x 109/l ili pad broja trombocita ispod 75 x 109/l potrebno je prekinuti liječenje kapecitabinom.
English: If these side effects continue, contact your doctor immediately.
Croatian: Ako se nuspojave ne povuku, odmah se obratite svom liječniku.
English: • blood-thinning medicines (coumarin, warfarin),
Croatian: • lijekove protiv zgrušavanja krvi (kumarin, varfarin),
English: What Capecitabine Accord looks like and contents of the pack
Croatian: Kako Kapecitabin Accord izgleda i sadržaj pakiranja
English: A two-year mouse carcinogenicity study produced no evidence of carcinogenicity by capecitabine.
Croatian: Dvogodišnjim ispitivanjem karcinogenosti na miševima nije dokazana karcinogenost kapecitabina.
English: A person whose body weight is 80 kg and height is 1.80 m has a body surface area of 2.00 m2 and should take 5 tablets of 500 mg two times daily.
Croatian: Osoba čija tjelesna težina iznosi 80 kg, a visina 1,80 m ima tjelesnu površinu od 2,00 m2 mora uzimati 5 tableta od 500 mg dvaput dnevno.
English: Doses of capecitabine omitted for toxicity are not replaced.
Croatian: su izostavljene zbog toksičnosti ne smiju se nadoknađivati.
English: Table 10 Key efficacy results for the non-inferiority analysis of Study NO16967
Croatian: Tablica 10 Ključni rezultati djelotvornosti iz analize neinferiornosti u ispitivanju NO 16967
English: Aluminium/aluminium or PVC/PVdC/Aluminium blister containing 30, 60 or 120 film-coated tablets.
Croatian: Aluminij/aluminij ili PVC/PVdC/aluminij blister koji sadrži 30, 60 ili 120 filmom obloženih tableta.
English: • severe skin reaction such as skin rash, ulceration and blistering which may involve ulcers of the mouth, nose, genitalia, hands, feet and eyes (red and swollen eyes).
Croatian: • teške kožne reakcije poput osipa kože, vrijedova i mjehurića koji mogu obuhvaćati vrijedove u ustima, nosu, spolnim organima, šakama, stopalima i očima (crvene i otečene oči).
English: Capecitabine can induce severe skin reactions such as Stevens-Johnson syndrome and Toxic Epidermal Necrolysis.
Croatian: Teške kožne reakcije Kapecitabin Accord može potaknuti razvoj teških kožnih reakcija poput Stevens-Johnosonova sindroma i toksične epidermalne nekrolize.
English: Recommended posology (see section 5.1)
Croatian: Preporučeno doziranje (vidjeti dio 5.1)
English: It is therefore possible that Capecitabine Accord could affect your ability to drive a car or operate machines.
Croatian: Stoga postoji mogućnost utjecaja Kapecitabina Accord na sposobnost upravljanja vozilima i strojevima.
English: • blood infection, urinary tract infection, infection of the skin, infections in the nose and throat, fungal infections (including those of the mouth), influenza, gastroenteritis, tooth abscess,
Croatian: • infekcije krvi, infekcije mokraćnog sustava, infekcija kože, infekcije u nosu i grlu, gljivične infekcije (uključujući i u ustima), gripa, gastroenteritis, apsces zuba
English: Caution must be exercised in patients with central or peripheral nervous system disease, e.g. brain metastasis or neuropathy (see section 4.8).
Croatian: Pozornost se mora obratiti na bolesnike s bolešću središnjeg ili perifernog živčanog sustava, primjerice s metastazama u mozgu ili neuropatijom (vidjeti dio 4.8).
English: ITT *PPP=per-protocol population; **ITT=intent-to-treat population.
Croatian: ITT *PPP = populacija po protokolu; **ITT = populacija bolesnika predviđenih za liječenje.
English: Your doctor may instruct you to decrease the dose and/or temporarily discontinue treatment with Capecitabine Accord.
Croatian: Liječnik vam može savjetovati da smanjite dozu i/ili privremeno prestanete uzimati
English: Capecitabine should be permanently discontinued in patients who experience a severe skin reaction during treatment.
Croatian: Primjenu lijeka Kapecitabin Accord potrebno je trajno obustaviti u bolesnika koji razviju tešku kožnu reakciju tijekom liječenja.
English: These dose adjustment recommendations for renal impairment apply both to monotherapy and combination use (see also section “Elderly” below).
Croatian: Preporuke o prilagodbi doziranja u slučaju oštećenja bubrežne funkcije odnose se i na monoterapiju i na kombiniranu primjenu (vidjeti također ispod dio „Starije osobe“).
English: Table 8 Key efficacy results for the non-inferiority analysis of Study NO16966
Croatian: Tablica 8 Ključni rezultati djelotvornosti iz analize o neinferiornosti u ispitivanju NO 16966
English: Table 3 Capecitabine dose reduction schedule (3-weekly cycle or continuous treatment).
Croatian: Tablica 4 Raspored smanjivanja doze kapecitabina (ciklusi od 3 tjedna ili kontinuirano liječenje)
English: • cold sores or other herpes infections
Croatian: • herpes na usnici ili druge infekcije herpesom
English: • pain in the joints or in the limbs (extremities), chest or back
Croatian: • bolovi u zglobovima ili udovima (ekstremitetima), bolovi u prsima ili leđima
English: • inflammation leading to dysfunction or obstruction in bile secretion (cholestatic hepatitis)
Croatian: • upale koje dovode do disfunkcije ili zapreke u izlučivanju žuči (kolestatski hepatitis)
English: In patients with unrecognised DPD deficiency treated with capecitabine, as well as in those patients who test negative for specific DPYD variations ,life-threatening toxicities manifesting as acute overdose may occur (see section 4.9).
Croatian: U bolesnika s neprepoznatom deficijencijom DPD-a liječenih kapecitabinom, kao i u onih s negativnim nalazima testova na specifične varijacije gena DPYD, može doći do po život opasne toksičnosti koja se manifestira kao akutno predoziranje (vidjeti dio 4.9).
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any subsequent updates of the RMP.
Croatian: • Plan upravljanja rizikom (RMP)Nositelj odobrenja obavljat će dodatne farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom, a koji je opisan u Modulu 1.8.2 Odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim nadopunama Plana.
English: • gout medicines (allopurinol),
Croatian: • lijekove za giht (alopurinol),
English: • decrease in blood sodium, magnesium or calcium, increase in blood sugar
Croatian: • smanjenje natrija, magnezija ili kalcija u krvi, povišenje šećera u krvi
English: Contusion + For each term, the frequency count was based on ADRs of all grades.
Croatian: + za svaki pojam učestalost se temeljila na nuspojavama na lijek svih stupnjeva.
English: You might get the following side effects if you take a lot more capecitabine than you should, feeling or being sick, diarrhoea, inflammation or ulceration of the gut or mouth, pain or bleeding from the intestine or stomach, or bone marrow depression (reduction in certain kinds of blood cells).
Croatian: Možda ćete imati sljedeće nuspojave ako uzmete puno više kapecitabina nego što ste trebali, mučninu i povraćanje, proljev, upalu ili ulceraciju u probavnom sustavu ili ustima, bol ili krvarenje iz crijeva ili želuca, ili smanjenje koštane srži (smanjenje određene vrste krvnih stanica).
English: Ethnic factors: Following oral administration of 825 mg/m2 capecitabine twice daily for 14 days, Japanese patients (n=18) had about 36% lower Cmax and 24% lower AUC for capecitabine than Caucasian patients (n=22).
Croatian: Faktori etničke pripadnosti: nakon peroralne primjene 825 mg/m2 kapecitabina dvaput dnevno tijekom 14 dana, Japanci (n=18) su imali 36% niži Cmax i 24% niži AUC kapecitabina nego bijelci (n=22).
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Croatian: Ako imate dodatnih pitanja kako uzimati ovaj lijek, obratite se svom liječniku ili ljekarniku.