FrancophonIA/ELRC3.0 huggingface dataset:
English: Show them your pack of tablets.
Croatian: Pokažite im pakovanje s tabletama.
English: Hence, it is recommended to reevaluate the efficacy for the individual patient after 8 weeks of treatment.
Croatian: Stoga se preporučuje ponovno procijeniti djelotvornost terapije u pojedinog bolesnika nakon 8 tjedana liječenja.
English: Full treatment effect was observed between 2 and 8 weeks.
Croatian: Potpuni terapijski učinak opaža se između 2. i 8. tjedna.
English: You should swallow your tablet whole with a glass of water.
Croatian: Tabletu trebate progutati cijelu uz čašu vode.
English: Responder rate (treatment response)#
Croatian: Stopa odgovora (odgovor na liječenje)#
English: Your doctor will tell you whether you can take TOVIAZ with other medicines.
Croatian: Liječnik će Vam reći smijete li uzimati TOVIAZ s drugim lijekovima.
English: Do not give this medicine to children and adolescents below 18 years of age because it is yet to be established whether it would work for them and whether it would be safe.
Croatian: Nemojte davati ovaj lijek djeci i adolescentima u dobi manjoj od 18 godina zato što se tek treba ustanoviti je li u njih lijek djelotvoran i siguran.
English: TOVIAZ should be used with caution in patients with:
Croatian: TOVIAZ treba primjenjivati s oprezom u bolesnika sa:
English: Do not throw away any medicines via wastewater or household waste.
Croatian: Nemojte nikakve lijekove bacati u otpadne vode ili kućni otpad.
English: If you forget to take a tablet, take your tablet as soon as you remember, but do not take more than one tablet in one day.
Croatian: Ako zaboravite uzeti tabletu, uzmite je čim se sjetite, ali nemojte uzeti više od jedne tablete na dan.
English: Serious allergic reactions including angioedema occurred rarely.
Croatian: Ozbiljne alergijske reakcije uključujući angioedem rijetko su se javljale.
English: The safety and efficacy of TOVIAZ in children below 18 years of age have not yet been established.
Croatian: Sigurnost i djelotvornost lijeka TOVIAZ u djece u dobi do 18 godina nisu još ustanovljene.
English: A dose reduction to 4 mg may be needed (see section 4.4).
Croatian: Možda bude potrebno sniziti dozu na 4 mg (vidjeti dio 4.4).
English: Female (79%) and male (21%) patients with a mean age of 58 years (range 19-91 years) were included.
Croatian: Ispitivanje je uključilo žene (79%) i muškarce (21%) prosječne dobi od 58 godina (raspon 19-91 godina).
English: Fesoterodine is a competitive, specific muscarinic receptor antagonist.
Croatian: Fesoterodin je kompetitivni, specifični antagonist muskarinskih receptora.
English: Very common (may affect more than 1 in 10 people) You may get a dry mouth.
Croatian: Vrlo česte (mogu se javiti u više od 1 na 10 osoba) Možete imati suha usta.
English: Tablets are to be taken once daily with liquid and swallowed whole.
Croatian: Tablete se uzimaju jedanput na dan s tekućinom i trebaju se progutati cijele.
English: Maximum plasma levels are reached after approximately 5 hours.
Croatian: Najviše razine u plazmi postižu se nakon približno 5 sati.
English: In patients with a combination of these factors, additional exposure increases are expected.
Croatian: U bolesnika s kombinacijom ovih čimbenika očekuje se povećana izloženost.
English: Bioavailability of the active metabolite is 52%.
Croatian: Bioraspoloživost djelatnog metabolita je 52%.
English: What TOVIAZ is and what it is used for
Croatian: Što je TOVIAZ i za što se koristi
English: Number of micturitions per 24 hours#
Croatian: Broj mokrenja u 24 sata#
English: Other medicines and TOVIAZ
Croatian: Drugi lijekovi i TOVIAZ
English: Please inform your doctor if you are taking medicines according to the following list.
Croatian: Obavijestite svog liječnika ako uzimate lijekove na sljedećem popisu.
English: No dose adjustment is recommended in these subpopulations.
Croatian: Ne preporučuje se prilagodba doze u ovih populacijskih skupina.
English: Number of urge incontinence episodes per 24 hours
Croatian: Broj epizoda urgentne inkontinencije u 24 sata
English: Do not chew the tablet.
Croatian: Nemojte žvakati tabletu.
English: Clinical efficacy and safety
Croatian: Klinička sigurnost i djelotvornost
English: Sealed pack Do not use if box has been opened
Croatian: Nemojte koristiti ako je kutija otvorena.
English: • Toxic megacolon.
Croatian: • toksični megakolon.
English: Date of first authorisation: 20 April 2007 Date of latest renewal: 15 March 2012
Croatian: Datum posljednje obnove odobrenja: 15. ožujka 2012.
English: You should not take TOVIAZ if you are pregnant, as the effects of fesoterodine on pregnancy and the unborn baby are not known.
Croatian: Ne smijete uzimati TOVIAZ ako ste trudni jer nisu poznati učinci fesoterodina na trudnoću i nerođeno dijete.
English: Active comparator
Croatian: Aktivni komparator
English: The adverse reactions are reported in this table with the following frequency convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (1/1,000 to <1/100), rare (1/10,000 to <1/1,000).
Croatian: Nuspojave su u ovoj tablici zabilježene prema sljedećoj konvenciji prikaza učestalosti: vrlo često (≥ 1/10), često (≥ 1/100 do < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000).
English: See sections 4.3, 4.4 and 4.5
Croatian: Vidjeti dijelove 4.3, 4.4 i 4.5.
English: If you experience any of these effects, do not drive or use any tools or machines.
Croatian: ako osjetite takve učinke, nemojte upravljati vozilima, koristiti alate niti raditi na strojevima.
English: Furthermore, fesoterodine improved the mean change in the voided volume per micturition, and the mean change in the number of continent days per week (see Table 1 below).
Croatian: Nadalje, fesoterodin je poboljšao prosječnu promjenu volumena izmokrene mokraće po mokrenju i prosječnu promjenu broja kontinentnih dana tjedno (vidjeti niže tablicu 1).
English: Treat symptoms as follows:
Croatian: Simptomi se liječe na sljedeći način:
English: Fesoterodine may not always be suitable for you.
Croatian: Fesoterodin ne mora uvijek biti pogodan lijek za Vas.
English: Likewise, the response rate (% of patients reporting that their condition has been “greatly improved” or “improved” using a 4-point Treatment Benefit Scale) was significantly greater with fesoterodine compared to placebo.
Croatian: Isto tako, postotak odgovora (% bolesnika koji su prijavili da im se stanje „uvelike poboljšalo“ ili „poboljšalo“ na četverostupanjskoj ljestvici za mjerenje koristi od liječenja) bio je značajno veći kod fesoterodina nego kod placeba.
English: Pfizer Europe MA EEIG (as MA Holder logo)
Croatian: Pfizer Europe MA EEIG (kao logo
English: The relation to fesoterodine treatment is unclear.
Croatian: Odnos s liječenjem fesoterodinom nije jasan.
English: The maximum daily dose is 8 mg.
Croatian: Maksimalna dnevna doza je 8 mg.
English: If you take more TOVIAZ than you should
Croatian: Ako uzmete više lijeka TOVIAZ nego što ste trebali
English: Table 1: Mean changes from Baseline to end of treatment for primary and selected secondary endpoints Study 1
Croatian: Tablica 1: Prosječne promjene od početka do završetka liječenja za primarne i odabrane sekundarne ishode
English: This effect is usually mild or moderate.
Croatian: Taj je učinak obično blag do umjeren.
English: TOVIAZ has minor influence on the ability to drive and use machines.
Croatian: TOVIAZ ima manji utjecaj na sposobnost upravljanja vozilima i rada na strojevima.
English: Dose increases
Croatian: Povišenje doze
English: TOVIAZ is not recommended during pregnancy.
Croatian: Ne preporučuje se koristiti TOVIAZ tijekom trudnoće.
English: Therefore, you should brush your teeth regularly twice daily and see a dentist when in doubt.
Croatian: Može dovesti do povećanog rizika od zubnog karijesa pa stoga treba redovito prati zube dvaput na dan i u slučaju sumnje posjetiti zubara.
English: No clinical trials have been conducted to assess the effect of fesoterodine on human fertility.
Croatian: Nisu provedena klinička ispitivanja u kojima bi se procijenio učinak fesoterodina na plodnost u ljudi.
English: Voided volume per micturition (ml)
Croatian: Izmokreni volumen po mokrenju (ml)
English: In non-clinical safety pharmacology, general toxicity, genotoxicity and carcinogenicity studies no clinically relevant effects have been observed, except those related to the pharmacological effect of the active substance.
Croatian: U nekliničkim ispitivanjima sigurnosne farmakologije, opće toksičnosti, genotoksičnosti i kancerogenosti nisu opaženi klinički važni učinci, osim oni povezani s farmakološkim učinkom djelatne tvari.
English: • Myasthenia gravis
Croatian: • miastenija gravis
English: The mean steady-state volume of distribution following intravenous infusion of the active metabolite is 169 l.
Croatian: Prosječni volumen distribucije u stanju dinamičke ravnoteže nakon intravenske infuzije djelatnog metabolita je 169 l.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja galaktoze, nedostatka Lapp laktaze i malapsorpcijom glukozegalaktoze ne smiju uzimati ovaj lijek.
English: Based on how you respond to the medicine, your doctor may prescribe you a higher dose; one 8 mg tablet a day.
Croatian: Ovisno o tome kako ćete odgovoriti na lijek, liječnik Vam može propisati višu dozu: jednu tabletu od 8 mg na dan.
English: What you need to know before you take TOVIAZ
Croatian: Što morate znati prije nego počnete uzimati TOVIAZ
English: TOVIAZ can cause blurred vision, dizziness, and sleepiness.
Croatian: TOVIAZ može izazvati zamagljeni vid, omaglicu i pospanost.
English: To help you remember to take your medicine, you may find it easier to take it at the same time every day.
Croatian: Možda ćete se lakše sjetiti uzeti tabletu ako je uzimate svaki dan u isto vrijeme.
English: The effect of weak CYP3A4 inhibitors (e.g. cimetidine), was not examined; it is not expected to be in excess of the effect of moderate inhibitor.
Croatian: Učinak slabih inhibitora CYP3A4 (npr. cimetidina) nije bio ispitan; ne očekuje se da će imati veći učinak od umjereno jakih inhibitora.
English: Oral contraceptives
Croatian: Oralna kontracepcija
English: The maternal No-Observed-Effect Level (NOEL) and the NOEL for effects on reproduction and early embryonic development were both 15 mg/kg/day.
Croatian: No-ObservedEffect Level) i NOEL za učinke na reprodukciju i rani embrionalni razvoj iznosila je 15 mg/kg na dan.
English: Safety and efficacy have not yet been established in patients with a neurogenic cause for detrusor overactivity.
Croatian: Sigurnost i djelotvornost u bolesnika s neurogenim uzrokom pretjerane aktivnosti detrusora još nisu ustanovljene.
English: Caution should be exercised when prescribing or uptitrating fesoterodine to patients in whom an increased exposure to the active metabolite (see section 5.1) is expected:
Croatian: Potreban je oprez kod propisivanja ili povišenja doze fesoterodina u bolesnika u kojih se očekuje povećana izloženost djelatnom metabolitu (vidjeti dio 5.1):
English: The interaction with CYP2D6 inhibitors was not tested clinically.
Croatian: Interakcija s inhibitorima CYP2D6 nije klinički provjerena.
English: There are no adequate data from the use of fesoterodine in pregnant women.
Croatian: Nema odgovarajućih podataka o primjeni fesoterodina u trudnica.
English: Reproduction studies have shown minor embryotoxicity at doses close to maternally toxic ones (increased number of resorptions, pre-implantation and post-implantation losses).
Croatian: Ispitivanja reproduktivne toksičnosti pokazala su manju embriotoksičnost pri dozama koje su blizu toksičnim dozama za majku (povećan broj resorpcija, predimplantacijski i postimplantacijski gubici).
English: TOVIAZ can be taken with or without food.
Croatian: TOVIAZ se može uzimati s hranom ili bez nje.
English: What TOVIAZ contains
Croatian: Što TOVIAZ sadrži
English: What TOVIAZ looks like and contents of the pack
Croatian: Kako TOVIAZ izgleda i sadržaj pakovanja
English: Pharmacotherapeutic group: Urologicals, Urinary antispasmodics, ATC code: G04BD11.
Croatian: Farmakoterapijska skupina: urologici, urinarni antispazmolitici, ATK oznaka: G04BD11.
English: A clinical study in healthy volunteers has shown that fesoterodine 8 mg once daily has no significant effect on the pharmacokinetics or the anticoagulant activity of a single dose of warfarin.
Croatian: Kliničko ispitivanje u zdravih dobrovoljaca pokazalo je da fesoterodin u dozi od 8 mg jedanput na dan nema značajnog učinka na farmakokinetiku ili antikoagulacijsko djelovanje jednokratne doze varfarina.
English: Overdose with antimuscarinics, including fesoterodine can result in severe anticholinergic effects.
Croatian: Predoziranje antimuskarinskim lijekovima, uključujući fesoterodin, može imati teške antikolinergičke učinke.
English: • Severe hepatic impairment (Child Pugh C)
Croatian: • teško oštećenje funkcije jetre (Child Pugh C)
English: It is rapidly and extensively hydrolysed by non-specific plasma esterases to the 5-hydroxymethyl derivative, its primary active metabolite, which is the main active pharmacological principle of fesoterodine.
Croatian: Brzo ga i opsežno hidroliziraju nespecifične esteraze u plazmi do 5-hidroksimetilnog derivata, njegovog primarnog djelatnog metabolita, koji je glavni farmakološki djelatni oblik fesoterodina.
English: Induction of CYP3A4 may lead to subtherapeutic plasma levels.
Croatian: Indukcija CYP3A4 može izazvati subterapijske razine u plazmi.
English: The clinical relevance of these findings will depend on individual patient risk factors and susceptibilities present (see section 4.4).
Croatian: Klinička važnost ovih nalaza ovisit će o čimbenicima rizika koji su prisutni u pojedinog bolesnika i njegovoj osjetljivosti (vidjeti dio 4.4).
English: Plasma protein binding of the active metabolite is low with approximately 50% bound to albumin and alpha-1-acid glycoprotein.
Croatian: Vezanje djelatnog metabolita za proteine plazme je nisko: približno 50% vezano je za albumin i alfa-1-kiseli glikoprotein.
English: Reproductive toxicity studies with fesoterodine in animals show minor embryotoxicity.
Croatian: Ispitivanja reproduktivne toksičnosti fesoterodina na životinjama pokazala su manju embriotoksičnost.
English: Findings in mice at exposures approximately 5 to 19 times those at the MRHD show an effect on female fertility, however, the clinical implications of these animal findings are not known (see section 5.3).
Croatian: Rezultati dobiveni u miševa pri izloženostima otprilike 5 do 19 puta većim od onih pri MRHD-u pokazuju učinak na plodnost ženki, no kliničke implikacije ovih rezultata dobivenih tijekom ispitivanja na životinjama nisu poznate (vidjeti dio 5.3).
English: Paediatric population Interaction studies have only been performed in adults.
Croatian: Pedijatrijska populacija Ispitivanja interakcija su jedino provedena kod odraslih osoba.
English: Based on AUC, the systemic exposure was 0.6 to 1.5 times higher in mice than in humans at the MRHD, whereas based on peak plasma concentrations, the exposure in mice was 5 to 9 times higher.
Croatian: Na temelju AUC, sustavna izloženost bila je 0,6 do 1,5 puta veća u miševa nego u ljudi pri MRHD, dok je na temelju vršnih koncentracija u plazmi, izloženost u miševa bila 5 do 9 puta veća.
English: None of these metabolites contribute significantly to the antimuscarinic activity of fesoterodine.
Croatian: Niti jedan od tih metabolita ne pridonosi značajno antimuskarinskom djelovanju fesoterodina.
English: Women of child bearing potential should be made aware of the lack of human fertility data, and TOVIAZ should only be given after consideration of individual risks and benefits.
Croatian: Žene reproduktivne dobi trebaju znati da nema podataka o utjecaju na plodnost kod ljudi, a TOVIAZ se smije primijeniti samo nakon razmatranja rizika i koristi u pojedine žene.
English: After single or multiple-dose oral administration of fesoterodine in doses from 4 mg to 28 mg, plasma concentrations of the active metabolite are proportional to the dose.
Croatian: Nakon jednokratne ili višestruke peroralne primjene fesoterodina u dozi od 4 mg do 28 mg, koncentracije u plazmi djelatnog metabolita proporcionalne su dozi.
English: TOVIAZ is available in blister packs of 7, 14, 28, 30, 56, 84, 98 and 100 prolonged-release tablets.
Croatian: TOVIAZ je dostupan u blister pakovanjima od 7, 14, 28, 30, 56, 84, 98 i 100 tableta s produljenim oslobađanjem.
English: (1) Mild GFR = 50-80 ml/min; Moderate GFR = 30-50 ml/min; Severe GFR = <30 ml/min (2) Cautious dose increase.
Croatian: (1) malo smanjenje brzine glomerularne filtracije (GFR) = 50-80 ml/min; umjereno smanjenje GFR = 30-50 ml/min; jako smanjenje GFR = <30 ml/min (2) Oprez kod povišenja doze.
English: Contains lactose and soya lecithin: see the package leaflet for further information.
Croatian: Sadrži laktozu i soju lecitin: vidjeti uputu o lijeku za dodatne informacije.
English: In populations where the dose may be increased to 8 mg once daily, the dose increase should be preceded by an evaluation of the individual response and tolerability.
Croatian: U populacijama kod kojih se doza može povisiti na 8 mg jedanput na dan, prije povišenja doze treba procijeniti odgovor i podnošljivost u pojedinog bolesnika.
English: The majority of adverse reactions occurred during the first month of treatment with the exception of cases classified as urinary retention or post void residual urine greater than 200 ml, which could occur after long term treatment and was more common in male than female subjects.
Croatian: Većina nuspojava nastala je tijekom prvog mjeseca liječenja uz izuzetak slučajeva kategoriziranih kao retencija mokraće ili volumen zaostale mokraće nakon mokrenja veći od 200 ml, koji su mogli nastati nakon dugotrajnog liječenja i bili su češći u muških nego ženskih ispitanika.
English: Fesoterodine may reduce the effect of medicinal products that stimulate the motility of the gastro-intestinal tract, such as metoclopramide.
Croatian: Fesoterodin može smanjiti učinak lijekova koji potiču motilitet gastrointestinalnog trakta, kao što je metoklopramid.
English: The recommended starting dose of TOVIAZ is one 4 mg tablet a day.
Croatian: Preporučena početna doza lijeka TOVIAZ je jedna tableta od 4 mg na dan.
English: TOVIAZ contains an active substance called fesoterodine fumarate, and is a so called antimuscarinic treatment which reduces the activity of an overactive bladder and it is used in adults to treat the symptoms.
Croatian: TOVIAZ sadrži djelatnu tvar koja se zove fesoterodinfumarat i ona je takozvani antimuskarinski lijek koji smanjuje aktivnost pretjerano aktivnog mokraćnog mjehura i primjenjuje se u odraslih za liječenje tih simptoma.
English: If angioedema occurs, fesoterodine should be discontinued and appropriate therapy should be promptly provided.
Croatian: Ako se razvije angioedem, potrebno je prekinuti primjenu fesoterodina i odmah osigurati odgovarajuću terapiju.
English: The safety of fesoterodine was evaluated in placebo-controlled clinical studies in a total of 2859 patients with overactive bladder, of which 780 received placebo.
Croatian: Sigurnost primjene fesoterodina procijenjena je u placebom kontroliranim kliničkim ispitivanjima u ukupno 2859 bolesnika s pretjerano aktivnim mokraćnim mjehurom, od kojih je 780 primalo placebo.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke šećere, obratite se liječniku prije nego što uzmete ovaj lijek.
English: After oral administration, fesoterodine is rapidly and extensively hydrolysed to its active metabolite.
Croatian: Nakon peroralne primjene, fesoterodin brzo se i opsežno hidrolizira do svog djelatnog metabolita.
English: Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine po učestalosti nuspojave su prikazane redoslijedom prema sve manjoj ozbiljnosti.
English: TOVIAZ is indicated in adults for treatment of the symptoms (increased urinary frequency and/or urgency and/or urgency incontinence) that may occur with overactive bladder syndrome.
Croatian: TOVIAZ se primjenjuje kod odraslih osoba za liječenje simptoma (povećana učestalost mokrenja i/ili urgencija i/ili urgentna inkontinencija) koji mogu nastati kod sindroma pretjerano aktivnog mokraćnog mjehura.
English: Based upon individual response, the dose may be increased to 8 mg once daily.
Croatian: Na temelju odgovora pojedinog bolesnika, doza se može povisiti na 8 mg jedanput na dan.
English: TOVIAZ is contraindicated in subjects with severe hepatic impairment (see section 4.3).
Croatian: TOVIAZ je kontraindiciran u osoba s teškim oštećenjem funkcije jetre (vidjeti dio 4.3).
English: The coating: polyvinyl alcohol, titanium dioxide (E171), macrogol (3350), talc, soya lecithin, indigo carmine aluminium lake (E132).
Croatian: Ovojnica tablete: polivinilni alkohol, titanijev dioksid (E171), makrogol (3350), talk, sojin lecitin, boja Indigo carmine aluminium lake (E132).
English: Therapeutic plasma levels are achieved after the first administration of fesoterodine.
Croatian: Terapijske razine u plazmi postižu se nakon prve primjene fesoterodina.
English: In the presence of fesoterodine there are no changes in the plasma concentrations of combined oral contraceptives containing ethinylestradiol and levonorgestrel.
Croatian: Prisutnost fesoterodina ne izaziva promjene koncentracija u plazmi kombiniranih oralnih kontraceptiva koji sadrže etinilestradiol i levonorgestrel.
English: In the event of overdose, ECG monitoring is recommended; standard supportive measures for managing QT prolongation should be adopted.
Croatian: U slučaju predoziranja preporučuje se elektrokardiografsko praćenje; potrebno je primijeniti standardne potporne mjere za liječenje produljenja QT intervala.
English: If you stop taking TOVIAZ
Croatian: Ako prestanete uzimati TOVIAZ
English: In a study of fertility and early embryonic development in mice, fesoterodine had no effect on male reproductive function or fertility at doses up to 45 mg/kg/day.
Croatian: U ispitivanju utjecaja na plodnost i rani embrionalni razvoj u miševa, fesoterodin nije imao učinka na reproduktivnu funkciju ili plodnost mužjaka pri dozama do 45 mg/kg na dan.
English: The terminal half-life of the active metabolite following oral administration is approximately 7 hours and is absorption rate-limited.
Croatian: Terminalni poluvijek djelatnog metabolita nakon peroralne primjene iznosi približno 7 sati i ograničen je brzinom apsorpcije.
English: This especially holds true when taking potent CYP3A4 inhibitors (see sections 4.2, 4.5 and 5.1).
Croatian: To osobito vrijedi za uzimanje jakih inhibitora CYP3A4 (vidjeti dijelove 4.2, 4.5 i 5.1).
English: Fesoterodine does not impair the suppression of ovulation by oral hormonal contraception.
Croatian: Fesoterodin ne smanjuje supresiju ovulacije izazvanu oralnom hormonskom kontracepcijom.
English: Paediatric population The pharmacokinetics of fesoterodine have not been evaluated in paediatric patients.
Croatian: Pedijatrijska populacija Farmakokinetika fesoterodina nije ispitana u pedijatrijskih bolesnika.
English: Post-marketing cases of urinary retention requiring catheterisation have been described, generally within the first week of treatment with fesoterodine.
Croatian: Nakon stavljanja lijeka u promet opisani su slučajevi retencije mokraće kod kojih se morala napraviti kateterizacija, obično tijekom prvog tjedna liječenja fesoterodinom.
English: Do not use this medicine after the expiry date which is stated on the carton and the blister after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza „Rok valjanosti“.
English: Hepatic metabolism and renal excretion contribute significantly to the elimination of the active metabolite.
Croatian: Jetreni metabolizam i izlučivanje bubregom značajno pridonose eliminaciji djelatnog metabolita.