FrancophonIA/ELRC3.0 huggingface dataset:
English: • epidemiological studies\non-interventional or observational studies,
Slovenian: · v epidemioloških študijah/neinterventnih ali opazovalnih študijah ali · s presojo poročil posameznih primerov.
English: Ask your doctor, pharmacist or nurse for advice before taking any medicine.
Slovenian: Posvetujte se z zdravnikom, farmacevtom ali medicinsko sestro, preden vzamete katero koli zdravilo.
English: Patients with untreated CNS metastases were routinely excluded from clinical trials with Avastin, based on imaging procedures or signs and symptoms.
Slovenian: Bolniki z nezdravljenimi zasevki v osrednjem živčevju so bili rutinsko izključeni iz kliničnih preskušanj z zdravilom Avastin, glede na postopke slikanj ali znake in simptome.
English: Depending on the dose prescribed for you, some or all of the contents of the Avastin vial will be diluted with sodium chloride solution before use.
Slovenian: Odvisno od odmerka, ki vam ga je predpisal zdravnik, je treba del ali vso vsebino viale zdravila Avastin pred uporabo razredčiti z raztopino natrijevega klorida.
English: In an exploratory analysis, the extent of Avastin benefit on overall survival was less pronounced in the subgroup of patients who did not have adenocarcinoma histology.
Slovenian: V eksplorativni analizi so ugotovili, da je bila korist zdravila Avastin glede celokupnega preživetja manj izražena v podskupini bolnikov, ki ni imela adenokarcinoma.
English: Hypertensive encephalopathy (very rare) (see also section 4.4 and Hypertension in section 4.8)
Slovenian: Bolezni živčevja hipertenzivna encefalopatija (zelo redko) (glejte tudi poglavje 4.4 in odstavek Hipertenzija v poglavju 4.8)
English: Statistical analyses were performed independently for 1) patients who received capecitabine in combination with Avastin or placebo; 2) patients who received taxane-based or anthracycline-based chemotherapy in combination with Avastin or placebo.
Slovenian: Statistične analize so neodvisno izvedli za 1) bolnike, ki so prejemali kapecitabin v kombinaciji z zdravilom Avastin ali placebom; 2) bolnike, ki so prejemali kemoterapijo na osnovi taksanov ali antraciklinov v kombinaciji z zdravilom Avastin ali placebom.
English: SPECIAL STORAGE CONDITIONS Store in a refrigerator (2°C - 8°C).
Slovenian: 6.4 Posebna navodila za shranjevanje Shranjujte v hladilniku (2 °C - 8 °C).
English: There was no exclusion criterion for prior anti-angiogenic therapy.
Slovenian: Predhodna antiangiogena terapija ni bila izključitveni kriterij.
English: Hypertension was generally adequately controlled with oral anti-hypertensives such as angiotensin-converting enzyme inhibitors, diuretics and calcium-channel blockers.
Slovenian: Hipertenzija je bila v večini primerov ustrezno uravnana s peroralnimi antihipertenzivi, kot so zaviralci angiotenzinske konvertaze, diuretiki in blokatorji kalcijevih kanalčkov.
English: Fatal outcome was reported in approximately a third of serious cases of gastrointestinal perforations, which represents between 0.2%-1% of all Avastin treated patients.
Slovenian: Smrtni izidi so bili zabeleženi v približno tretjini resnih primerov perforacij prebavil; to pomeni od 0,2 do 1 % vseh bolnikov, zdravljenih z zdravilom Avastin.
English: 60.0 years in the CP arm and 59.0 years in the CPB arm.
Slovenian: Mediana starost je bila 60,0 let v skupini CP in 59,0 let v skupini CPB.
English: The value for clearance is, on average, equal to 0.188 and 0.220 L/day for female and male patients, respectively.
Slovenian: Povprečna vrednost za očistek je bila pri bolnicah 0,188 l/dan, pri bolnikih pa 0,220 l/dan.
English: The corresponding frequencies in the control group receiving chemotherapy alone were 1.1% vs. 0.8%, respectively.
Slovenian: Ustrezajoče pogostnosti v kontrolni skupini, ki je prejemala samo kemoterapijo so bile 1,1 % v primerjavi z 0,8 %.
English: There have also been less common reactions of minor mucocutaneous haemorrhage in other locations, such as gingival bleeding or vaginal bleeding.
Slovenian: Manj pogosto je prihajalo tudi do manjših krvavitev iz kože in sluznic na drugih mestih, kot na primer krvavitev iz dlesni ali vaginalnih krvavitev.
English: Palmar-plantar erythrodysaesthesia syndrome
Slovenian: sindrom palmarnoplantarne eritrodisestezije
English: *Bevacizumab is a recombinant humanised monoclonal antibody produced by DNA technology in Chinese Hamster Ovary cells.
Slovenian: *Bevacizumab je rekombinantno humanizirano monoklonsko protitelo, pridobljeno s tehnologijo rekombinantne DNA iz celic ovarija kitajskega hrčka.
English: Tables 1 and 2 list adverse reactions associated with the use of Avastin in combination with different chemotherapy regimens in multiple indications.
Slovenian: V preglednicah 1 in 2 so našteti neželeni učinki, ki so povezani z uporabo zdravila Avastin v kombinaciji z različnimi shemami kemoterapije pri več indikacijah.
English: Tell your doctor if you are using platinum- or taxane-based therapies for lung or metastatic breast cancer.
Slovenian: Obvestite svojega zdravnika, če za zdravljenje pljučnega raka ali metastatskega raka dojk prejemate zdravila, ki vsebujejo platino ali taksane.
English: Furthermore, 65% of patients had received adjuvant chemotherapy including 19% prior taxanes and 49% prior anthracyclines.
Slovenian: Adjuvantno kemoterapijo je prejelo 65 % bolnikov, od tega 19 % taksane in 49 % antracikline.
English: Overall approximately 34% of patients were FIGO Stage III optimally debulked with gross residual disease, 40% Stage III sub-optimally debulked, and 26% were Stage IV patients.
Slovenian: Celokupno je približno 34 % bolnic imelo po FIGO klasifikaciji bolezen stadija III, z opravljeno optimalno citoredukcijo, s preostankom bolezni; 40 % jih je imelo bolezen stadija III, z opravljeno suboptimalno citoredukcijo in 26 % je imelo bolezen stadija IV.
English: Therapy should not be initiated for at least 28 days following major surgery or until the surgical wound is fully healed.
Slovenian: Zdravljenja ne smemo začeti, če je od večje operacije minilo manj kot 28 dni ali dokler se kirurška rana popolnoma ne zaceli.
English: If you are considering having children you should discuss this with your doctor before your treatment starts.
Slovenian: V primeru, da razmišljate o zanositvi, se posvetujte s svojim zdravnikom, preden začnete z zdravljenjem.
English: The primary endpoint was PFS based on investigator's assessment of disease progression based on radiological scans or CA 125 levels, or symptomatic deterioration per protocol.
Slovenian: Primarni cilj študije je bil preživetje brez napredovanja bolezni, ki temelji na oceni raziskovalca o napredovanju bolezni glede na radiološki posnetek ali določitvi vrednosti CA 125 oziroma na simptomatsko poslabšanje glede na protokol.
English: Secondary PFS analyses, based on ‘on-treatment'-based response assessments, confirmed the significantly superior clinical benefit for patients treated with Avastin (analyses shown in Table 7), consistent with the statistically significant benefit observed in the pooled analysis.
Slovenian: Sekundarne analize preživetja brez napredovanja bolezni, ki so temeljile na ocenah odgovora ob zdravljenju (¢on-treatment¢), so potrdile signifikantno superiorno klinično korist za bolnike, ki so jih zdravili z zdravilom Avastin (analiza prikazana v preglednici 7), kar je v skladu s statistično signifikantno koristjo, ki so jo opazili v združenih analizah podatkov.
English: Investigator assessment
Slovenian: Ocena raziskovalca
English: For further information please refer to Table 3 'Adverse reactions reported in post-marketing setting.'
Slovenian: a Za nadaljnje informacije, prosimo, glejte preglednico 3 »Neželeni učinki, o katerih so poročali po prihodu zdravila na trg«.
English: In both studies, bevacizumb exposure trended lower as body weight decreased.
Slovenian: V obeh študijah se je izpostavljenost bevacizumabu z manjšanjem telesne mase zmanjševala.
English: Bevacizumab binds to vascular endothelial growth factor (VEGF), the key driver of vasculogenesis and angiogenesis, and thereby inhibits the binding of VEGF to its receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2), on the surface of endothelial cells.
Slovenian: Mehanizem delovanja Bevacizumab se veže na vaskularni endotelijski rastni faktor (VEGF - vascular endothelial growth factor), ki je ključni dejavnik vaskulogeneze in angiogeneze, in s tem zavira vezavo VEGF na njegova receptorja Flt-1 (VEGFR-1) in KDR (VEGFR-2) na površini endotelijskih celic.
English: Most patients were FIGO Stage IIIC or Stage IV.
Slovenian: Večina bolnic je imela stadij IIIC ali IV po klasifikaciji FIGO.
English: Statistically significant improvements in progression-free survival and objective response rate were also observed (see Table 8).
Slovenian: Opazili so tudi statistično značilna izboljšanja v preživetju brez napredovanja bolezni in objektivnem odgovoru na zdravljenje (glejte preglednico 8).
English: Reactions (frequency*)
Slovenian: Neželeni učinki (pogostnost*)
English: Day 1, prior to XELOX, q 3 weeks
Slovenian: 1. dan, pred XELOX, vsake 3 tedne
English: No incompatibilities between Avastin and polyvinyl chloride or polyolefine bags or infusion sets have been observed.
Slovenian: Med zdravilom Avastin in polivinil kloridom ali poliolefinskimi vrečkami ali infuzijskimi seti ni bilo inkompatibilnosti.
English: The overall safety profile of Avastin is based on data from over 5,700 patients with various malignancies, predominantly treated with Avastin in combination with chemotherapy in clinical trials.
Slovenian: Celotni varnostni profil zdravila Avastin temelji na podatkih več kot 5700 bolnikov z različnimi malignimi boleznimi, ki so se v kliničnih preskušanjih večinoma zdravili z zdravilom Avastin v kombinaciji s kemoterapijo.
English: The addition of Avastin to FOLFOX-4 resulted in a statistically significant prolongation of survival.
Slovenian: Dodatek zdravila Avastin k zdravljenju po shemi FOLFOX-4 je statistično značilno podaljšal preživetje.
English: • feeling of numbness or tingling in hands or feet,
Slovenian: · občutek otrplosti ali zbadanja v dlaneh ali nogah,
English: The majority of the patients in each treatment arm (74% and 71%) had poorly differentiated (Grade 3) primary tumours at baseline.
Slovenian: Večina bolnic v vsaki skupini (74 % in 71 %) je imela pred začetkom zdravljenja slabo diferenciran (stopnje 3) primarni tumor.
English: After discontinuation of bevacizumab treatment, ovarian function recovered in the majority of patients.
Slovenian: Po prekinitvi zdravljenja z bevacizumabom se je delovanje jajčnikov izboljšalo pri večini bolnic.
English: It is recommended that the treatment with Avastin in addition to erlotinib is continued until disease progression.
Slovenian: Priporočamo, da se zdravljenje z zdravilom Avastin kot dodatek erlotinibu nadaljuje do napredovanja bolezni.
English: It is therefore not authorised to be used in this way.
Slovenian: Niso ga pripravili za injiciranje v oko, zato njegova uporaba na ta način ni odobrena.
English: Very common (affects more than 1 user in 10) side effects, which were not severe, include:
Slovenian: Zelo pogosti (pojavijo se pri več kot 1 od 10 bolnikov) neželeni učinki, ki pa niso bili hudi, vključujejo:
English: During the trial, of the patients who received trial treatment, 32.2% (136/422) of patients received 7-12 administrations of Avastin and 21.1% (89/422) of patients received 13 or more administrations of Avastin.
Slovenian: Med preskušanjem je od bolnikov, ki so prejemali zdravilo v preskušanju, 32,2 % bolnikov (136/422) prejelo 7 do 12 odmerkov zdravila Avastin, 21,1 % (89/422) bolnikov pa je prejelo 13 ali več odmerkov zdravila Avastin.
English: The patient characteristics were similar across the trial arms.
Slovenian: V vseh preiskovanih skupinah so bile karakteristike bolnikov podobne.
English: Table 22 Efficacy results1,2 from study GOG-0213 Primary Endpoint
Slovenian: Preglednica 22 Rezultati učinkovitosti1,2 iz študije GOG-0213 Primarni opazovani dogodek
English: The concentrate is a clear, colourless to pale brown liquid in a glass vial with a rubber stopper.
Slovenian: Koncentrat je bistra, brezbarvna do rahlo rjava tekočina v stekleni viali z gumijastim zamaškom.
English: Singapore
Slovenian: Singapur
English: 1, the drug could be delivered as a 1-hour infusion.
Slovenian: Po prvem ciklusu se lahko zdravilo daje kot 1-urna infuzija.
English: In order to improve the traceability of biological medicinal products, the trade name and the batch number of the administered product should be clearly recorded (or stated) in the patient file.
Slovenian: 4.4 Posebna opozorila in previdnostni ukrepi Za izboljšanje sledljivosti bioloških zdravil je treba lastniško ime in številko serije uporabljenega zdravila jasno zabeležiti (navesti) v bolnikovo kartoteko.
English: For the posology and method of administration of erlotinib, please refer to the full erlotinib prescribing information.
Slovenian: Za odmerjanje in način uporabe erlotiniba, prosimo, glejte celotni povzetek glavnih značilnosti erlotiniba.
English: An exploratory multivariate Cox regression model using backward selection indicated that the following baseline prognostic factors were strongly associated with survival independent of treatment: gender, white blood cell count, platelets, body weight loss in the 6 months prior to trial entry, number of metastatic sites, sum of longest diameter of target lesions, Motzer score.
Slovenian: S pomočjo eksplorativnega multivariantnega Coxovega regresijskega modela s selekcijo nazaj so ugotovili, da so naslednji izhodiščni napovedni dejavniki močno povezani s preživetjem, neodvisno od zdravljenja: spol, število belih krvnih celic, trombocitov, izguba telesne mase 6 mesecev pred vstopom v preskušanje, število metastatskih mest, vsota najdaljših premerov tarčnih lezij, rezultat po Motzerju.
English: ● Avastin may increase the risk of developing serious infections of the skin or deeper layers under the skin, especially if you had holes in the gut wall or problems with wound healing.
Slovenian: · zdravilo Avastin lahko poveča tveganje za nastanek resnih okužb kože ali globljih plasti pod kožo, še posebej, če se vam je stena črevesja preluknjala ali ste imeli težave pri celjenju ran.
English: ● It is possible that Avastin can increase the risk of bleeding in your lungs, including coughing or spitting blood.
Slovenian: · možno je, da lahko zdravilo Avastin poveča tveganje za krvavitve v pljučih, vključno s kašljanjem in izpljuvanjem krvi.
English: The necessary amount of bevacizumab should be withdrawn and diluted to the required administration volume with sodium chloride 9 mg/ml (0.9%) solution for injection.
Slovenian: Potrebno količino bevacizumaba je potrebno odvzeti in jo razredčiti do ustreznega volumna za aplikacijo z 9 mg/ml (0,9-%) raztopino natrijevega klorida za injiciranje.
English: An increased incidence of post-operative bleeding or wound healing complication occurring within 60 days of major surgery was observed if the patient was being treated with Avastin at the time of surgery.
Slovenian: Povečano incidenco za pooperativno krvavitev ali zaplet pri celjenju ran, ki se pojavi v 60 dneh po večji operaciji, so opazili v primerih, ko se je bolnik v času operacije zdravil z zdravilom Avastin.
English: Of the 722 patients in the trial, the majority of patients had HER2-negative disease (90%), with a small number of patients with unknown (8%) or confirmed HER2-positive status (2%), who had previously been treated with or were considered unsuitable for trastuzumab therapy.
Slovenian: Od 722 bolnikov v preskušanju je večina bolnikov imela HER-2 negativno bolezen (90 %), manjše število bolnikov pa je imelo neznan (8 %) ali potrjen HER-2 pozitivni status (2 %).
English: The occurrence of those events varied in type and severity, ranging from free air seen on the plain abdominal X-ray, which resolved without treatment, to intestinal perforation with abdominal abscess and fatal outcome.
Slovenian: Pojavljanje teh neželenih dogodkov se je razlikovalo po vrsti in resnosti: od prostega zraka, vidnega na nativnem rentgenogramu, ki je spontano izvenel, do perforacije črevesja z abdominalnimi abscesi in smrtnim izidom.
English: ● if you have problems with wound healing following surgery,
Slovenian: · če imate težave s celjenjem ran po operaciji, · če boste operirani,
English: Follow-up analysis was performed with a data cut-off date of 07 March 2014; all p-values are displayed for descriptive purpose only
Slovenian: 2 Analizo po spremljanju so opravili s podatki, zajetimi do 7. marca 2014; vse vrednosti p so napisane samo za deskriptivne namene.
English: You must not breast-feed your baby during treatment with Avastin and for at least 6 months after the last dose of Avastin, as this medicine may interfere with the growth and development of your baby.
Slovenian: Med zdravljenjem z zdravilom Avastin in še najmanj 6 mesecev po njegovem zadnjem odmerku otroka ne smete dojiti, ker lahko to zdravilo vpliva na rast in razvoj vašega otroka.
English: Pain in the mouth, teeth and/or jaw, swelling or sores inside the mouth, numbness or a feeling of heaviness in the jaw, or loosening of a tooth.
Slovenian: Bolečina v ustih, zobeh in/ali čeljusti, otekline ali mehurji v ustih, otrplost ali občutek teže v čeljusti ali razmajanost zoba.
English: In most clinical trials of Avastin, patients with pre-existing CHF of NYHA (New York Heart Association) II-IV were excluded, therefore, no information is available on the risk of CHF in this population.
Slovenian: V večino kliničnih preskušanj z zdravilom Avastin bolniki, ki so imeli kongestivno srčno popuščanje pred pričetkom zdravljenja (NYHA - New York Heart Association II-IV), niso bili vključeni, zato informacije o tveganju za kongestivno srčno popuščanje pri tej populaciji niso na voljo.
English: Avastin in combination with interferon alfa-2a for the first-line treatment of advanced and/ or metastatic renal cell cancer (BO17705)
Slovenian: Zdravilo Avastin v kombinaciji z interferonom alfa 2-a v prvi liniji zdravljenja napredovalega in/ali metastatskega raka ledvičnih celic (BO17705)
English: a Interferon alfa-2a 9 MIU 3x/week b
Slovenian: a interferon alfa-2a 9 mio 3x/teden b bevacizumab 10 mg/kg vsake 2 tedna
English: 0.65 (p < 0.0001) 95% CI (0.56; 0.76)
Slovenian: 0,65 (p < 0,0001) 95-% interval zaupanja (0,56; 0,76)
English: Progression-free survival (PFS)
Slovenian: Preživetje brez napredovanja bolezni (PFS)
English: Keep the vial in the outer carton
Slovenian: Vialo shranjujte v zunanji ovojnini
English: In adults, the results showed no significant difference in the pharmacokinetics of bevacizumab in relation to age.
Slovenian: Rezultati so pokazali, da pri odraslih ni značilnih razlik v farmakokinetiki bevacuzimaba glede na starost.
English: Description of selected serious adverse reactions
Slovenian: Opis določenih resnih neželenih učinkov
English: The pharmacokinetics of bevacizumab was well characterized by the paediatric population PK model for 70 patients in Study BO20924 ((1.4 to 17.6 years; 11.6 to 77.5 kg) and 59 patients in Study BO25041 (1 to 17 years; 11.2 to 82.3 kg).
Slovenian: Farmakokinetika bevacizumaba je bila dobro opredeljena z uporabo farmakokinetičnega modela pediatrične populacije za 70 bolnikov iz študije BO20294 (1,4 do 17,6 let; 11,6 do 77,5 kg) in za 59 bolnikov iz študije BO25041 (1 do 17 let; 11,2 do 82,3 kg).
English: 0.838 [CI: 0.693, 1.014]
Slovenian: 0,838 [IZ: 0,693; 1,014]
English: Other medicines and Avastin
Slovenian: Druga zdravila in zdravilo Avastin
English: No AEs leading to death occurred in either treatment arm; all deaths were attributed to disease progression.
Slovenian: V nobeni od zdravljenih skupin ni bilo neželenih učinkov, ki bi bili smrtni; vsi smrtni primeri so bili zaradi napredovanja bolezni.
English: assessment)**
Slovenian: Ocena IRF**
English: For additional information refer below within section "Further information on selected serious adverse reactions"
Slovenian: d Za nadaljnje informacije glejte spodnje podpoglavje »Dodatne informacije o določenih resnih neželenih učinkih«.
English: The efficacy results of Avastin in combination with IFL-chemotherapy are displayed in Table 4.
Slovenian: Rezultate učinkovitosti zdravila Avastin v kombinaciji z IFL-kemoterapijo prikazuje preglednica 4.
English: In patients who experienced wound healing complications during therapy, treatment should be withheld until the wound is fully healed.
Slovenian: Pri bolnikih, pri katerih je med zdravljenjem prišlo do zapleta pri celjenju ran, dajanje začasno prekinemo, dokler se rana popolnoma ne zaceli.
English: Efficacy Results for Study ML18147 (ITT population)
Slovenian: Rezultati učinkovitosti za študijo ML18147 (populacija bolnikov, ki so jo nameravali zdraviti)
English: Grade 3 proteinuria was reported in up to 10.9% of treated patients.
Slovenian: O proteinuriji stopnje 3 so poročali pri največ 10,9 % zdravljenih bolnikov.
English: In terms of safety, there was a higher overall incidence of Grade 3-5 AEs in study E3200 relative to study ML18147.
Slovenian: Kar se tiče varnosti, je bila v študiji E3200 celokupno večja incidenca neželenih dogodkov stopnje 3-5 glede na študijo ML18147.
English: The findings ranged from asymptomatic declines in left ventricular ejection fraction to symptomatic CHF, requiring treatment or hospitalisation.
Slovenian: Ti učinki so segali od asimptomatskega zmanjšanja iztisnega deleža levega prekata do simptomatskega kongestivnega srčnega popuščanja, za katerega je bilo potrebno zdravljenje ali hospitalizacija.
English: An adverse effect on female fertility can however be expected as repeat dose toxicity studies in animals have shown inhibition of the maturation of ovarian follicles and a decrease/absence of corpora lutea and associated decrease in ovarian and uterus weight as well as a decrease in the number of menstrual cycles.
Slovenian: Pričakovan pa je škodljiv učinek na plodnost žensk, saj so študije toksičnosti pri večkratnih odmerkih na živalih pokazale zaviranje zorenja ovarijskih foliklov in zmanjšanje/odsotnost rumenega telesca ter s tem povezano zmanjšanje mase jajčnika in maternice ter zmanjšanje števila menstrualnih ciklov.
English: Follow-up analysis was performed with a data cut-off date of 07 March 2014 8 p-value displayed for descriptive purpose only
Slovenian: Analizo po spremljanju so opravili s podatki, zajetimi do 7. marca 2014. 8 Vrednost p je napisana samo za deskriptivne namene.
English: Toxicity and adverse reactions included arterial hypertension and fatigue as well as CNS ischaemia with acute neurological deficit.
Slovenian: Toksičnosti in neželeni učinki so vključevali arterijsko hipertenzijo in utrujenost ter ishemijo centralnega živčnega sistema z akutnim nevrološkim pomanjkanjem.
English: Avastin infusions should not be administered or mixed with glucose solutions.
Slovenian: Infuzije zdravila Avastin se ne sme dajati ali mešati skupaj z raztopinami glukoze.
English: An interim analysis showed there was a significant prolongation of the time to progression of disease in the 10 mg/kg group as compared with the placebo group (hazard ratio, 2.55; p < 0.001).
Slovenian: Vmesna analiza je pokazala, da je čas do napredovanja bolezni pomembno podaljšan v skupini, ki je prejemala 10 mg/kg, v primerjavi s skupino, ki je prejemala placebo (razmerje ogroženosti 2,55; p < 0,001).
English: Avastin is also used for the treatment of adult patients with advanced non-small cell lung cancer when cancer cells have specific mutations of a protein called epidermal growth factor receptor (EGFR).
Slovenian: Zdravilo Avastin uporabljamo tudi za zdravljenje odraslih bolnikov z napredovalim nedrobnoceličnim rakom pljuč, ko imajo rakave celice določene mutacije beljakovine, ki se imenuje receptor epidermalnega rastnega faktorja (EGFR).
English: FOLFOX-4 or XELOX + placebo (n=701)
Slovenian: FOLFOX-4 ali XELOX + placebo (n = 701)
English: Statistically significant improvements in progression-free survival were also observed.
Slovenian: Statistično značilno izboljšanje so opazili tudi pri preživetju brez napredovanja bolezni.