FrancophonIA/ELRC3.0 huggingface dataset:
English: Interaction with saquinavir/ritonavir not evaluated.
Danish: - Interaktion med saquinavir/ritonavir er ikke undersøgt.
English: - Indinavir 800 mg tid (saquinavir 600-1200 mg single dose)
Danish: - Indinavir 800 mg 3 gange daglig (saquinavir 6001.200 mg enkeltdosis)
English: NAME OF THE MEDICINAL PRODUCT Invirase 500 mg film-coated tablets Saquinavir
Danish: LÆGEMIDLETS NAVN Invirase 500 mg filmovertrukne tabletter Saquinavir
English: Saquinavir AUC ↑ 13% (90% CI: 27↓ - 74↑) Saquinavir Cmax ↑ 9% (90% CI: 27↓ - 61↑ ) Nelfinavir AUC ↓ 6% (90% CI: 28↓ - 22↑) Nelfinavir Cmax ↓ 5% (90% CI: 23↓ - 16↑)
Danish: (90 % konfidensinterval: 27↓ -74↑) Saquinavir Cmax ↑ 9 % (90 % konfidensinterval: 27↓ -61↑) Nelfinavir AUC ↓ 6 % (90 % konfidensinterval: 28↓ -22↑) Nelfinavir Cmax ↓ 5 % (90 % konfidensinterval: 23↓ -16↑)
English: • an allergy to saquinavir, ritonavir or any of the other ingredients (see “Invirase contains lactose”
Danish: • hvis du er allergisk over for saquinavir, ritonavir eller et af de øvrige indholdsstoffer i Invirase
English: In the MaxCmin2 study, the safety and efficacy of saquinavir soft capsules/ritonavir 1000/100 mg twice daily plus 2 NRTIs/NNRTIs was compared with lopinavir/ritonavir 400/100 mg twice daily plus 2 NRTIs/NNRTIs in 324 (both protease inhibitor treatment naïve and experienced) subjects.
Danish: I MaxCmin2-studiet blev sikkerhed og effekt af saquinavir bløde kapsler/ritonavir 1.000/100 mg 2 gange daglig plus 2 NRTIs/NNRTIs sammenlignet med lopinavir/ritonavir 400/100 mg 2 gange daglig plus 2 NRTIs/NNRTIs hos 324 patienter (både naive og tidligere proteasehæmmerebehandlede).
English: It is not recommended to coadminister Invirase/ritonavir with cobicistat containing products (see section 4.4).
Danish: Invirase/ritonavir sammen med produkter indeholdende cobicistat (se pkt.
English: This is due to induction of drug metabolising enzymes and/or transport proteins by St. John's wort.
Danish: Dette skyldes at perikon virker inducerende på lægemiddelmetaboliserende enzymer og/eller kan påvirke transportproteiner.
English: Efavirenz 600 mg qd (saquinavir/ritonavir 1600/200 mg qd, or saquinavir/ritonavir 1000/100 mg bid, or saquinavir/ritonavir 1200/100 mg qd)
Danish: Efavirenz 600 mg 1 gang daglig (saquinavir/ritonavir 1.600/200 mg 1 gang daglig eller saquinavir/ritonavir 1.000/100 mg 2 gange daglig eller saquinavir/ritonavir 1.200/100 mg 1 gang daglig)
English: Rifabutin 150 mg q3d (saquinavir/ritonavir 1000/100 mg bid) in healthy volunteers
Danish: Rifabutin 150 mg hver 3. dag (saquinavir/ritonavir 1.000/100 mg 2 gange daglig) hos raske frivillige
English: • medicines used to lower blood cholesterol - such as statins
Danish: • kolesterolsænkende lægemidler - såsom statiner
English: Fluticasone propionate 50 mcg qid, intranasal (ritonavir 100 mg bid)
Danish: Fluticasonpropionat 50 µg 4 gange daglig, intranasal (ritonavir 100 mg 2 gange daglig)
English: The effect of treatment initiation with a dosing regimen of Invirase/ritonavir 500 /100 mg twice daily in combination with 2 NRTIs for the first 7 days of treatment followed by Invirase/ritonavir 1000 / 100 mg twice daily in combination with 2 NRTIs in the subsequent 7 days on QTc interval, PK, and viral load was evaluated in an open-label 2-week observational study in 23 HIV-1 infected, treatmentnaïve patients initiating Invirase/ritonavir therapy.
Danish: Effekten på QTc-interval, farmakokinetik og viral belastning af behandlingsinitiering med et dosisregime med Invirase/ritonavir 500 mg/100 mg 2 gange daglig i kombination med 2 NRTI'er i de første 7 dage af behandlingen efterfulgt af Invirase/ritonavir 1.000 mg/100 mg 2 gange daglig i kombination med 2 NRTI'er i de efterfølgende 7 dage blev evalueret i et ublindet 2 ugers observationsstudie hos 23 hiv-1-inficerede, behandlingsnaive patienter, der skulle påbegynde Invirase/ritonavir-behandling.
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Danish: Du skal straks informere din læge for at få den nødvendige behandling, hvis du bemærker symptomer på infektion eller andre symptomer, såsom muskelsvaghed, svaghed begyndende i hænder og fødder, og som bevæger sig op igennem kroppen, hjertebanken, rysten eller hyperaktivitet
English: Clarithromycin is a CYP3A4 substrate and is associated with QT prolongation.
Danish: - Clarithromycin er et CYP3A4-substrat og er associeret med QT-forlængelse.
English: Erythromycin is a CYP3A4 substrate and is associated with QT prolongation.
Danish: - Erythromycin er et CYP3A4-substrat og er associeret med QT-forlængelse.
English: However, dizziness, fatigue and visual impairment have been reported during treatment with Invirase.
Danish: Der er dog rapporteret om svimmelhed, træthed og synsnedsættelse efter anvendelse af Invirase.
English: Do not take Invirase if you are taking any of the following medicines:
Danish: Tag ikke Invirase, hvis du tager eller får nogen af følgende lægemidler: Lægemidler som kan ændre din hjerterytme, såsom:
English: Concomitant use of tacrolimus and saquinavir/ritonavir is expected to increase plasma levels of tacrolimus.
Danish: Samtidig brug af tacrolimus og saquinavir/ritonavir forventes at øge plasmakoncentrationen af tacrolimus.
English: Sildenafil Cmax ↑ 140 % Sildenafil AUC ↑ 210 %
Danish: Sildenafil AUC ↑ 210 %
English: Clarithromycin 500 mg bid (unboosted saquinavir 1200 mg tid)
Danish: - Clarithromycin 500 mg 2 gange daglig (ikke-boostet saquinavir 1.200 mg 3 gange daglig)
English: Therefore, the co-administration of boosted saquinavir and tipranavir, co-administered with low dose ritonavir, is not recommended.
Danish: Derfor anbefales det ikke at anvende en kombination af saquinavir og tipranavir begge boostet med lavdosis ritonavir.
English: • ergot alkaloids - for migraine attacks
Danish: • sekalealkaloider - anvendes til behandling af migræneanfald
English: Erythromycin 250 mg qid (unboosted saquinavir 1200 mg tid)
Danish: - Erythromycin 250 mg 4 gange daglig (ikke-boostet saquinavir 1.200 mg
English: • concurrent therapy with any of the following drugs, which may interact and result in potentially life-threatening undesirable effects (see sections 4.4, 4.5 and 4.8): - drugs that prolong the QT and/or PR interval (see sections 4.4 and 4.5) - midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5), triazolam (potential for prolonged or increased sedation, respiratory depression) - simvastatin, lovastatin (increased risk of myopathy including rhabdomyolysis) - ergot alkaloids (e.g. ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (potential for acute ergot toxicity) - rifampicin (risk of severe hepatocellular toxicity) (see sections 4.4, 4.5, and 4.8) - quetiapine (risk of coma, see section 4.5).
Danish: 4.5 om forsigtighed ved parenteralt administreret midazolam), triazolam (risiko for forlænget eller øget sedation, respirationsdepression) - simvastatin, lovastatin (øget risiko for myopati herunder rabdomyolyse) - sekale alkaloider (f.eks. ergotamin, dihydroergotamin, ergonovin og methylergonovin) (risiko for akut sekale-toksicitet) - rifampicin (risiko for alvorlig hepatocellulær toksicitet) (se pkt.
English: Concomitant use of alfuzosin and saquinavir/ritonavir is expected to increase plasma levels of alfuzosin.
Danish: Samtidig brug af alfuzosin og saquinavir/ritonavir forventes at øge plasmakoncentrationen af alfuzosin.
English: Oral contraceptives Ethinyl estradiol (saquinavir/ritonavir)
Danish: Orale kontraceptiva Ethinylestradiol (saquinavir/ritonavir)
English: Thioridazine Ziprasidone (saquinavir/ritonavir)
Danish: Thioridazin Ziprasidon (saquinavir/ritonavir)
English: Monitoring of saquinavir plasma concentration is recommended (see section 4.4).
Danish: Monitorering af saquinavir plasmakoncentrationen anbefales (se pkt.
English: Anticoagulant Warfarin (saquinavir/ritonavir)
Danish: Antikoagulantia Warfarin (saquinavir/ritonavir)
English: Table 9: Mean (CV%) PK Parameters following administration of the Modified Invirase/ritonavir Regimen in Treatment Naïve HIV-1 infected Patients initiating treatment with Invirase/ritonavir Parameter Day 3 500/100 mg (n=22)
Danish: Tabel 9: Middel (CV%) farmakokinetiske parametre efter administration af det modificerede Invirase/ritonavir-regime i behandlingsnaive hiv-1-inficerede patienter, der indledte behandling med Invirase/ritonavir.
English: Fluconazole/miconazole (saquinavir/ritonavir)
Danish: Fluconazol/miconazol (saquinavir/ritonavir)
English: Narcotic analgesics Methadone 60-120 mg qd (saquinavir/ritonavir 1000/100 mg bid)
Danish: Narkotiske analgetika Methadon 60-120 mg 1 gang daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Antihistamines Terfenadine Astemizole (saquinavir/ritonavir)
Danish: Antihistaminer Terfenadin Astemizol (saquinavir/ritonavir)
English: - For treatment-naïve patients initiating treatment with Invirase/ritonavir 500/100 mg two times daily for the first 7 days of treatment followed by Invirase 1000 mg two times daily with ritonavir 100 mg two times daily after 7 days and with a baseline QT interval < 450 msec, an on-treatment ECG is suggested after approximately 10 days of therapy.
Danish: - For behandlingsnaive patienter med et baseline-QT-interval < 450 ms, der påbegynder behandling med Invirase/ritonavir 500 mg/100 mg 2 gange daglig i de første 7 dage, efterfulgt af Invirase/ritonavir 1.000 mg/100 mg 2 gange daglig, anbefales det at tage et opfølgende ekg efter ca. 10 dages behandling.
English: Concomitant use of salmeterol and saquinavir/ritonavir is expected to increase plasma levels of salmeterol.
Danish: Samtidig brug af salmeterol og saquinavir/ritonavir forventes at øge plasmakoncentrationen af salmeterol.
English: Mean Maximal
Danish: Gennemsnit af maksimal
English: Liver disease: The safety and efficacy of saquinavir/ritonavir has not been established in patients with significant underlying liver disorders, therefore saquinavir/ritonavir should be used cautiously in this patient population.
Danish: Leversygdom: Sikkerheden og effekten af saquinavir/ritonavir er ikke blevet undersøgt hos patienter med betydende, underliggende leversygdom.
English: HIV fusion inhibitor Enfuvirtide (saquinavir/ritonavir 1000/100 mg bid)
Danish: Hiv-fusionshæmmer Enfuvirtid (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Alopecia, dry skin, eczema, lipoatrophy, pruritus, rash
Danish: Alopeci, tør hud, eksem, lipoatrofi, kløe, udslæt
English: Renal impairment: Renal clearance is only a minor elimination pathway, the principal route of metabolism and excretion for saquinavir being via the liver.
Danish: Nedsat nyrefunktion: Renal clearance er kun en mindre udskillelsesvej.
English: Invirase/ritonavir 1000/100 mg BID
Danish: Invirase/ritonavir 1.000/100 mg 2 gange daglig
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Danish: Laktoseintolerans: Invirase 500 mg filmovertrukne tabletter indeholder lactose og bør ikke anvendes til patienter med arvelig galactoseintolerans, en særlig form af arvelig lactasemangel (Lapp Lactase deficiency) eller glucose/galactosemalabsorption.
English: In HIV-infected patients, Invirase or saquinavir soft capsules in combination with ritonavir at doses of 1000/100 mg twice daily provide a systemic exposure of saquinavir over a 24 hour period similar to or greater than that achieved with saquinavir soft capsules 1200 mg three times daily (see section 5.2).
Danish: Ritonavir ↔ Hos hiv-inficerede patienter forårsagede Invirase eller saquinavir bløde kapsler i kombination med ritonavir i doser på 1.000/100 mg 2 gange daglig en systemisk belastning af saquinavir i en periode på 24 timer svarende til eller større end hvad der opnås med saquinavir bløde kapsler 1.200 mg 3 gange daglig (se pkt.
English: Streptogramin antibiotics (saquinavir/ritonavir)
Danish: - Streptograminantibiotika (saquinavir/ritonavir)
English: In this study, 5 patients were <2 years and 13 between 2 to <6 years and received 50 mg/kg saquinavir bid (not to exceed 1000 mg bid) boosted with ritonavir at 3 mg/kg for patients with body weight ranging from 5 to <15 kg or 2.5 mg/kg for patients with body weight ranging from 15 to 40 kg (not to exceed 100 mg bid).
Danish: De fik 50 mg/kg saquinavir to gange daglig (højst 1.000 mg to gange daglig) boostet med ritonavir 3 mg/kg for patienter med legemsvægt i intervallet 5 kg til < 15 kg og 2,5 mg/kg for patienter med legemsvægt i intervallet 15 kg til 40 kg (højst 100 mg to gange daglig).
English: Invirase (hard capsule) 600 mg tid saquinavir soft capsule 1200 mg tid Invirase (tablet) 1000 mg bid plus ritonavir 100 mg bid* (fasting condition) Invirase (tablet) 1000 mg bid plus ritonavir 100 mg bid* (high fat meal)
Danish: Invirase (tabletter) 1.000 mg 2 gange daglig plus ritonavir 100 mg to gange daglig* (fastende) Invirase (tabletter) 1.000 mg 2 gange daglig plus ritonavir 100 mg 2 gange daglig* (måltid med højt fedtindhold)
English: Day 3 mg (n=22)
Danish: Dag 3 mg (n=22)
English: Because of a potential increase of colchicine-related toxicity (neuromuscular events including rhabdomyolysis), its concomitant use with saquinavir/ritonavir is not recommended, especially in the case of renal or hepatic impairment (see section 4.4).
Danish: Det anbefales ikke at anvende colchicin samtidig med saquinavir/ritonavir på grund af mulig colchicinrelateret toksicitet (neuromuskulære bivirkninger, herunder rabdomyolyse), især ikke ved nedsat nyre- eller leverfunktion (se pkt.
English: Effect of food: In a cross-over study in 22 HIV-infected patients treated with Invirase/ritonavir 1000 mg/100 mg twice daily and receiving three consecutive doses under fasting conditions or after a high-fat, high-calorie meal (46 g fat, 1,091 Kcal), the AUC0-12, Cmax and Ctrough values of saquinavir under fasting conditions were about 70 per cent lower than with a high-fat meal.
Danish: Patienterne fik tre konsekutive doser under fastende betingelser eller efter et fedt- og kalorierigt måltid (46 g fedt, 1.091 kcal), hvor AUC0-12, Cmax og Ctrough værdier af saquinavir under fastende betingelser var omkring 70 % lavere end efter et måltid med højt fedtindhold.
English: Invirase/ritonavir 1500/100 mg BID
Danish: Invirase/ritonavir 1.500/100 mg 2 gange daglig
English: quinine, vincamine.
Danish: mizolastin, quinin, vincamin
English: Inform your doctor if you are pregnant or planning to become pregnant.
Danish: Hvis du er gravid eller ammer, har mistanke om, at du er gravid, eller planlægger at blive gravid, skal du spørge din læge eller apotekspersonalet til råds, før du tager Invirase.
English: HIV CCR5 antagonist Maraviroc 100 mg bid (saquinavir/ritonavir 1000/100 mg bid)
Danish: Hiv-CCR5-antagonist Maraviroc 100 mg 2 gange daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Tablet coat:
Danish: Tabletfilm:
English: bid = twice daily tid = three times daily * results are geometric mean (min - max) † derived from tid or bid dosing schedule
Danish: * resultaterne er geometriske gennemsnit (min - max) † afledt fra 2 eller 3 gange daglig dosering
English: Others
Danish: Ingen
English: For the full list of excipients, see section 6.1.
Danish: 4.4, for information om de enkelte lægemidler, se tabel 1).
English: 1000/100 mg bid)
Danish: 1.000/100 mg 2 gange daglig)
English: However, so far the available data are insufficient and do not identify specific risks for the unborn child. Saquinavir should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus (see section 5.3).
Danish: Saquinavir bør kun gives til gravide hvis den potentielle fordel retfærdiggør den potentielle risiko for fosteret (se pkt.
English: Tenofovir disoproxil fumarate 300 mg qd (saquinavir/ritonavir 1000/100 mg bid)
Danish: Tenofovirdisoproxil fumarat 300 mg 1 gang daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Conversely, other drugs that induce CYP3A4 may also reduce saquinavir plasma concentrations.
Danish: Omvendt kan andre lægemidler, der inducerer CYP3A4, reducere plasma koncentrationen af saquinavir og monitorering af plasmaniveauer af saquinavir kan være indiceret.
English: How to take Invirase
Danish: Sådan skal du tage Invirase
English: The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing this disease.
Danish: Til de mange risikofaktorer for udvikling af denne sygdom hører blandt andre: Hvor længe den samtidige behandling med flere antiretrovirale lægemidler varer, anvendelse af kortikosteroider, alkoholforbrug, alvorligt nedsat immunforsvar samt (over-)vægt (højere Body Mass Index (BMI)).
English: HIV protease inhibitors (PIs) Atazanavir 300 mg qd (saquinavir/ritonavir 1600/100 mg qd)
Danish: Hiv-proteasehæmmere (PI´er) Atazanavir 300 mg 1 gang daglig (saquinavir/ritonavir 1.600/100 mg 1 gang daglig)
English: Standard dose
Danish: Den sædvanlige dosis er
English: Concentration of ethinyl estradiol may be decreased when coadministered with Invirase/ritonavir.
Danish: Koncentrationen af ethinylestradiol kan falde når det administreres sammen med Invirase/ritonavir.
English: Concentrations of triazolam may be increased when co-administered with Invirase/ritonavir.
Danish: Koncentrationer af triazolam kan være øget ved co-administration med Invirase/ritonavir.
English: Switching directly from a rilpivirine containing regimen to Invirase/ritonavir is contraindicated as is concomitant use due to the potential for life threatening cardiac arrhythmia (see sections 4.3 and 4.4).
Danish: Direkte skift fra en rilpivirin-holdig behandling til Invirase/ritonavir, ligesom samtidig behandling med disser stoffer er kontraindiceret på grund af risikoen for livstruende hjertearytmi (se pkt.
English: - Nelfinavir 1250 mg bid (saquinavir/ritonavir 1000/100 mg bid)
Danish: - Nelfinavir 1.250 mg 2 gange daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Antifungals Ketoconazole 200 mg qd (saquinavir/ritonavir 1000/100 mg bid)
Danish: Antimykotika Ketoconazol 200 mg 1 gang daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: If you take more Invirase than you should
Danish: Hvis du har taget for meget Invirase
English: Patients with haemophilia: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthroses, in haemophiliac patients type A and B treated with protease inhibitors.
Danish: Patienter med hæmofili: Hos patienter med hæmofili A og B har der været flere meddelelser om spontan eller øget blødningstendens med spontane hudblødninger og ledblødninger under behandling med proteasehæmmere.
English: When bosentan is administered concomitantly with saquinavir/ritonavir, the patient's tolerability of bosentan should be monitored.
Danish: Patientens tolerance over for bosentan bør overvåges, hvis bosentan anvendes samtidig med saquinavir/ritonavir.
English: Abnormal heart rhythms (arrhythmias):
Danish: Uregelmæssige hjerterytmer (arytmier)
English: Maprotiline
Danish: Maprotilin
English: Cisapride (saquinavir/ritonavir)
Danish: Cisaprid (saquinavir/ritonavir)
English: Osteonecrosis: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Danish: Ætiologien anses dog for at være multifaktoriel (omfattende anvendelse af kortikosteroider, alkoholforbrug, svær immunosuppression, højere Body Mass Index (BMI)).
English: Monitoring for saquinavir toxicity recommended (see section 4.4).
Danish: Det anbefales at monitorere for saquinavir-toksicitet (se pkt.
English: Histamine H2-receptor antagonist - Ranitidine
Danish: Histamin H2-receptorantagonist - Ranitidin (saquinavir/ritonavir) - Ranitidin (ikke-boostet saquinavir)
English: Concentrations of these medicinal products increase several fold when co-administered with Invirase/ritonavir.
Danish: Koncentrationer af disse lægemidler øges mange gange ved co-administration med Invirase/ritonavir.
English: Whereas acute or chronic overdose of saquinavir alone did not result in major complications, in combination with other protease inhibitors, overdose symptoms and signs such as general weakness, fatigue, diarrhoea, nausea, vomiting, hair loss, dry mouth, hyponatraemia, weight loss and orthostatic hypotension have been observed.
Danish: Derimod er der observeret overdoseringssymptomer og tegn som generel svaghed, træthed, diarré, kvalme, opkastning, hårtab, mundtørhed, hyponatriæmi, vægttab og ortostatisk hypotension efter administration af saquinavir sammen med andre proteasehæmmere.
English: Didanosine 400 mg single dose (saquinavir/ritonavir 1600/100 mg qd)
Danish: 400 mg enkeltdosis (saquinavir/ritonavir 1.600/100 mg 1 gang daglig)
English: • some medicines that treat diseases related to the acid in the stomach - such as omeprazole or other proton pump inhibitors
Danish: • visse lægemidler, der anvendes til behandling af sygdomme, som skyldes for meget mavesyre såsom omeprazol eller andre syrepumpehæmmere
English: Itraconazole (saquinavir/ritonavir)
Danish: - Itraconazol (saquinavir/ritonavir)
English: Due to CYP3A inhibition by saquinavir/ritonavir, concentrations of lurasidone are expected to increase.
Danish: Koncentrationerne af lurasidon forventes at stige på grund af saquinavir/ritonavirs hæmning af CYP3A
English: - Nevirapine (saquinavir/ritonavir)
Danish: - Nevirapin (saquinavir/ritonavir)
English: Contraindicated in combination with saquinavir/ritonavir due to potentially life threatening cardiac arrhythmia (see section 4.3).
Danish: Kontraindiceret i kombination med saquinavir/ritonavir på grund af den livstruende hjertearytmi (se pkt.
English: Ritonavir 100 mg bid (saquinavir 1000 mg bid)
Danish: Ritonavir 100 mg 2 gange daglig (saquinavir 1.000 mg 2 gange daglig)
English: Fosamprenavir 700 mg bid (saquinavir/ritonavir 1000/100 mg bid)
Danish: Fosamprenavir 700 mg 2 gange daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Day 7 mg (n=21)
Danish: Dag 7 mg (n=21)
English: Concentrations of these medicinal products may be increased when coadministered with Invirase/ritonavir.
Danish: Koncentrationer af disse lægemidler kan være øget ved co-administration med Invirase/ritonavir.
English: Antimycobacterials Rifampicin 600 mg qd (saquinavir/ritonavir 1000/100 mg bid)
Danish: Antimykobakterielle midler Rifampicin 600 mg 1 gang daglig (saquinavir/ritonavir 1.000/100 mg 2 gange daglig)
English: Mizolastine (saquinavir/ritonavir)
Danish: Mizolastin (saquinavir/ritonavir)
English: Pimozide (saquinavir/ritonavir)
Danish: Pimozid (saquinavir/ritonavir)
English: Concentrations of pimozide may be increased when co-administered with Invirase/ritonavir.
Danish: Koncentrationer af pimozid kan blive øget ved co-administration med Invirase/ritonavir.
English: What Invirase looks like and contents of the pack
Danish: Udseende og pakningsstørrelser
English: Based on the finding of dose-dependent prolongations of QT and PR intervals in healthy volunteers receiving Invirase/ritonavir (see sections 4.3, 4.4 and 5.1), additive effects on QT and PR interval prolongation may occur.
Danish: Baseret på forekomsten af dosisafhængig forlængelse af QT- og PR-intervallet hos raske frivillige, som får Invirase/ritonavir (se pkt.
English: Due to CYP3A inhibition by saquinavir/ritonavir, concentrations of quetiapine are expected to increase.
Danish: Koncentrationerne af quetiapin forventes at stige på grund af saquinavir/ritonavirs hæmning af CYP3A
English: Concentrations of vardenafil may be increased when co-administered with Invirase/ritonavir.
Danish: Koncentrationer af vardenafil kan være øget ved co-administration med Invirase/ritonavir.
English: - Nefazodone (saquinavir/ritonavir)
Danish: - Nefazodon (saquinavir/ritonavir)