FrancophonIA/ELRC3.0 huggingface dataset:
English: Darunavir boosted with cobicistat is more sensitive to CYP3A induction than ritonavir-boosted darunavir: co-administration of darunavir/cobicistat with medicinal products that are strong inducers of CYP3A (e.g. St John's wort, rifampicin, carbamazepine, phenobarbital, and phenytoin) is contraindicated (see section 4.3).
Croatian: Darunavir pojačan s kobicistatom je osjetljiviji na CYP3A indukciju u odnosu na darunavir pojačan ritonavirom: kontraindicirana je istodobna primjena darunavira/kobicistata s lijekovima snažnim induktorima CYP3A (npr. gospina trava, rifampicin, karbamazepin, fenobarbital i fenitoin) (vidjeti dio 4.3).
English: Ear and labyrinth disorders uncommon vertigo
Croatian: Poremećaji uha i labirinta manje često vertigo
English: Co-administration of darunavir with low dose ritonavir, with active substances that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events.
Croatian: Istodobna primjena darunavira s niskom dozom ritonavira s lijekovima čiji klirens u velikoj mjeri ovisi o CYP3A i čije su povišene koncentracije u plazmi povezane s ozbiljnim i/ili po život opasnim događajima.
English: In the 96 week analysis, the safety profile of darunavir/ritonavir 800/100 mg once daily in treatmentnaïve subjects was similar to that seen with darunavir/ritonavir 600/100 mg twice daily in treatmentexperienced subjects except for nausea which was observed more frequently in treatment-naïve subjects.
Croatian: U 96 tjednoj analizi, sigurnosni profil primjene darunavira/ritonavira od 800/100 mg jedanput na dan u prethodno neliječenih ispitanika bio je sličan profilu primjene darunavira/ritonavira od 600/100 mg dvaput na dan u prethodno liječenih ispitanika, osim mučnine koja je češće opažena u prethodno neliječenih ispitanika.
English: Immune reconstitution inflammatory syndrome
Croatian: Upalni sindrom imunološke rekonstitucije
English: Tenofovir disoproxil 245 mg once daily tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% darunavir AUC ↑ 21% darunavir Cmin ↑ 24% darunavir Cmax ↑ 16% (↑ tenofovir from effect on MDR-1 transport in the renal tubules)
Croatian: Tenofovir dizoproksil 245 mg jedanput na dan tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% darunavir AUC ↑ 21% darunavir Cmin ↑ 24% darunavir Cmax ↑ 16% (↑ tenofovira zbog učinka na transport putem MDR-1 u bubrežnim tubulima)
English: The interaction trial showed a comparable daily systemic exposure for rifabutin between treatment at 300 mg once daily alone and 150 mg once every other day in combination with darunavir/ritonavir (600/100 mg twice daily) with an about 10fold increase in the daily exposure to the active metabolite 25-O-desacetylrifabutin.
Croatian: Ispitivanje interakcije pokazalo je usporedivu dnevnu sistemsku izloženost za rifabutin između liječenja s 300 mg jedanput na dan samostalno i 150 mg jedanput svaki drugi dan u kombinaciji s darunavirom/ritonavirom (600/100 mg dvaput na dan) uz oko 10 puta veću dnevnu izloženost aktivnom metabolitu 25-O-desacetilrifabutinu.
English: During the second trimester of pregnancy, cobicistat Cmax, AUC24h, and Cmin were 50%, 63%, and 83% lower, respectively, as compared with postpartum.
Croatian: Tijekom drugog tromjesečja trudnoće, Cmax, AUC24h, i Cmin kobicistata bile su 50%, 63% odnosno 83% niže u usporedbi s postpartalnim razdobljem.
English: The combination of rifapentine and boosted darunavir is not recommended.
Croatian: Kombinacija rifapentina i pojačanog darunavira se ne preporučuje.
English: Systemic dexamethasone should be used with caution when combined with boosted darunavir.
Croatian: Sistemski deksametazon mora se primijeniti s oprezom kada se kombinira s pojačanim darunavirom.
English: Clinical monitoring is recommended when co-administering darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered.
Croatian: Preporučuje se kliničko praćenje kada se istodobno primjenjuje darunavir s tim sedativima/hipnoticima i u obzir treba uzeti nižu dozu sedativa/hipnotika.
English: Amitriptyline Desipramine Imipramine Nortriptyline Trazodone paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
Croatian: Amitriptilin paroksetin AUC ↓ 39% paroksetin Cmin ↓ 37% paroksetin Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49% sertralin Cmin ↓ 49% sertralin Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
English: The pharmacokinetic enhancing effect of pharmacokinetic enhancer other than ritonavir on darunavir was evaluated in a Phase I study in healthy subjects that were administered darunavir 800 mg with ritonavir at 100 mg or other phrmacokinetic enhancer once daily.
Croatian: Učinak farmakokinetičkog pojačivanja farmakokinetičkog pojačivača osim ritonavira na darunavir bio je procijenjen u ispitivanju faze I u zdravih dobrovoljaca kojima je darunavir od 800 mg bio primijenjen bilo s ritonavirom od 100 mg ili drugim farmakokinetičkim pojačivačem jedanput na dan.
English: Reproductive system and breast disorders uncommon erectile dysfunction, gynaecomastia
Croatian: Poremećaji reproduktivnog sustava i dojki manje često erektilna disfunkcija, ginekomastija
English: Darunavir Krka contains the active substance darunavir.
Croatian: Darunavir Krka sadrži djelatnu tvar darunavir.
English: OTHER LIPID MODIFYING AGENTS Lomitapide
Croatian: DRUGI LIJEKOVI KOJI MODIFICIRAJU LIPIDE Lomitapid
English: When used in combination with darunavir co-administered with low dose ritonavir, dose adjustment of indinavir from 800 mg twice daily to 600 mg twice daily may be warranted in case of intolerance.
Croatian: Kada se darunavir primijeni istodobno s niskom dozom ritonavira u kombinaciji s indinavirom, može biti potrebna prilagodba doze indinavira s 800 mg dvaput na dan na 600 mg dvaput na dan u slučaju nepodnošljivosti.
English: CYP3A inducers that are contraindicated include rifampicin, St John's wort and lopinavir.
Croatian: Kontrainidicirani CYP3A induktori uključuju npr. rifampicin, gospinu travu i lopinavir.
English: Common side effects (may affect up to 1 in 10 people) vomiting, nausea, abdominal pain or distension, dyspepsia, flatulence headache, tiredness, dizziness, drowsiness, numbness, tingling or pain in hands or feet, loss of strength, difficulty falling asleep.
Croatian: Česte nuspojave (mogu se javiti u do 1 na 10 osoba) - povraćanje, mučnina, bol u trbuhu ili nadutost trbuha, probavne tegobe, vjetrovi - glavobolja, umor, omaglica, omamljenost, utrnulost, trnci ili bolovi u rukama ili stopalima, gubitak snage, poteškoće s usnivanjem.
English: Clinical monitoring is recommended when co-administering boosted darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered.
Croatian: Preporučuje se kliničko praćenje kada se istodobno primjenjuje pojačan darunavir s tim sedativima/hipnoticima i u obzir treba uzeti nižu dozu sedativa/hipnotika.
English: Coadministration with boosted darunavir may cause a large increase in the concentration of these medicines.
Croatian: Istodobna primjena s pojačanim darunavirom može izazvati velik porast koncentracije tih lijekova.
English: Medicinal products that affect darunavir exposure (ritonavir as pharmacoenhancer)
Croatian: Lijekovi koji utječu na izloženost darunaviru (uz ritonavir kao farmakokinetički pojačivač)
English: HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir Lopinavir/ritonavir
Croatian: Inhibitori Proteaze (IP) HIV-a - uz istodobnu primjenu niske doze ritonavira Lopinavir/ritonavir
English: Darunavir Krka cannot work properly without ritonavir and food.
Croatian: Darunavir Krka ne može pravilno djelovati bez ritonavira i hrane.
English: However, dizziness has been reported in some patients during treatment with regimens containing darunavir co-administered with cobicistat or low dose ritonavir and should be borne in mind when considering a patient's ability to drive or operate machinery (see section 4.8).
Croatian: Međutim, prijavljena je omaglica u nekih bolesnika tijekom liječenja režimima koji su sadržavali darunavir primijenjen istodobno s kobicistatom ili niskom dozom ritonavira, što se mora imati na umu kada se procjenjuje bolesnikova sposobnost vožnje ili upravljanja strojevima (vidjeti dio 4.8).
English: No interaction studies presented in the table have been performed with darunavir boosted with cobicistat.
Croatian: Ispitivanja interakcija, navedena u tablici niže, nisu bila provedena s darunavirom pojačanim s kobicistatom.
English: Darunavir given with low dose ritonavir may be considered as an alternative.
Croatian: Darunavir koji se daje s niskom dozom ritonavira može se uzeti u obzir kao zamjena.
English: Darunavir Krka600 mg tablets can be used to construct the twice daily 600 mg regimen.
Croatian: Darunavir Krka od 600 mg tablete mogu se primijeniti za dostizanje režima doziranja od 600 mg dvaput na dan.
English: ANTICOAGULANT/PLATELET AGGREGATION INHIBITOR Apixaban
Croatian: ANTIKOAGULANSI/INHIBITOR AGREGACIJE TROMOBOCITA
English: BOX
Croatian: KUTIJA
English: During the third trimester of pregnancy, cobicistat Cmax, AUC24h, and Cmin, were 27%, 49%, and 83% lower, respectively, as compared with postpartum.
Croatian: Tijekom trećeg tromjesečja trudnoće Cmax, AUC24h, i Cmin kobicistata bile su 27%, 49% odnosno 83% niže u usporedbi s postpartalnim razdobljem.
English: Nervous system disorders common headache, peripheral neuropathy, dizziness uncommon lethargy, paraesthesia, hypoaesthesia, dysgeusia, disturbance in attention, memory impairment, somnolence rare syncope, convulsion, ageusia, sleep phase rhythm disturbance
Croatian: Poremećaji živčanog sustava često glavobolja, periferna neuropatija, omaglica manje često letargija, parestezija, hipoestezija, disgeuzija, poremećaj pažnje, oštećenje pamćenja, somnolencija rijetko sinkopa, konvulzija, ageuzija, poremećaj ritma faza spavanja
English: The concomitant use with darunavir and low dose ritonavir may require to lower the dose of alfentanil and requires monitoring for risks of prolonged or delayed respiratory depression.
Croatian: Istodobna primjena s darunavirom i niskom dozom ritonavira može zahtijevati snižavanje doze alfentanila i zahtjeva praćenje rizika na produljenu ili odgođenu respiratornu depresiju.
English: Darunavir Krka is not for use in children younger than 3 years of age or weighing less than 15 kilograms.
Croatian: Darunavir Krka nije namijenjen za primjenu u djece mlađe od 3 godine ili tjelesne težine manje od 15 kilograma.
English: Darunavir Krka cannot work properly without ritonavir.
Croatian: Darunavir Krka ne može pravilno djelovati bez ritonavira.
English: Population pharmacokinetic analysis in HIV infected patients showed that darunavir pharmacokinetics are not considerably different in the age range (18 to 75 years) evaluated in HIV infected patients (n=12, age ≥ 65) (see section 4.4).
Croatian: Analiza populacijskih farmakokinetičkih podataka u HIV-om inficiranih bolesnika (n=12, dob ≥ 65) pokazala je da farmakokinetika darunavira nije bitno različita u rasponu dobi (18 do 75 godina) (vidjeti dio 4.4).
English: Other severe side effectswere diabetes (common) and inflammation of the pancreas (uncommon).
Croatian: Ostale teške nuspojave bile su šećerna bolest (često) i upala gušterače (manje često).
English: Nucleo(s/t)ide reverse transcriptase inhibitors (NRTIs) Didanosine
Croatian: Nukleo(z/t)idni inhibitori reverzne transkriptaze (NRTI) Didanozin
English: Take two 400 milligram tablets at the same time or one 800 miligram tablet, once a day, every day.
Croatian: - Uzimite dvije tablete od 400 miligrama u isto vrijeme ili jednu tabletu od
English: bottle of 30 film-coated tablets) and 90 film-coated tablets (3 bottles of 30 film-coated tablets) in a box.
Croatian: 30 filmom obloženih tableta (1 bočica s 30 filmom obloženih tableta) i 90 filmom obloženih tableta (3 bočice s 30 filmom obloženih tableta) u kutiji.
English: Caution should be exercised when clarithromycin is combined with boosted darunavir.
Croatian: Nužan je oprez kada se klaritromicin kombinira s pojačanim darunavirom.
English: The pharmacokinetic properties of darunavir, co-administered with ritonavir, have been evaluated in healthy adult volunteers and in HIV-1 infected patients.
Croatian: Farmakokinetička svojstva darunavira primijenjenog istodobno s ritonavirom, ispitivana su u zdravih odraslih dobrovoljaca i u bolesnika inficiranih s HIV-1.
English: TITAN is a randomised, controlled, open-label Phase III trial comparing darunavir co-administered with ritonavir (600/100 mg twice daily) versus lopinavir/ritonavir (400/100 mg twice daily) in ARTexperienced, lopinavir naïve HIV-1 infected adult patients.
Croatian: TITAN je randomizirano kontrolirano kliničko ispitivanje otvorenog tipa, faze III pri čemu je uspoređivan darunavir primijenjen istodobno s ritonavirom (600/100 mg dvaput na dan) naspram lopinavira/ritonavira (400/100 mg dvaput na dan) u odraslih bolesnika inficiranih HIV-1 prethodno liječenih ART-om, ali neliječenih lopinavirom.
English: Darunavir co-administered with cobicistat should not be used in combination with another antiretroviral agent that requires pharmacoenhancement by means of co-administration with an inhibitor of CYP3A4 (see section 4.5).
Croatian: Darunavir istodobno primijenjen s kobicistatom ne smije se uzimati u kombinaciji s drugim antiretrovirusnim lijekovima koji zahtijevaju farmakokinetičko pojačanje u smislu istodobne primjene s inhibitorom CYP3A4 (vidjeti dio 4.5).
English: Darunavir Krkamust be taken in combination with a low dose of ritonavir and other anti-HIV medicines.
Croatian: Darunavir Krka se mora uzimati u kombinaciji s niskom dozom ritonavira i drugim lijekovima protiv HIV-a.
English: No adjustment of methadone dosage is required when initiating coadministration with boosted darunavir.
Croatian: Prilagodba doziranja metadona nije potrebna kada se započinje istodobna primjena s pojačanim darunavirom.
English: It is recommended that the international normalised ratio (INR) be monitored when warfarin is combined with boosted darunavir.
Croatian: Preporučuje se praćenje protrombinskog vremena (INR, od engl. international normalised ratio) kada se varfarin primjenjuje u kombinaciji s pojačanim darunavirom.
English: A dose reduction of the co-administered drug may be needed in these cases.
Croatian: U tim slučajevima može biti potrebno smanjiti dozu istodobno primijenjenog lijeka.
English: Ethinylestradiol Norethindrone 35 μg/1 mg once daily drospirenone AUC ↑ 58% drospirenone Cmin ND drospirenone Cmax ↑ 15%
Croatian: 35 μg/1 mg jedanput na dan drospirenon AUC ↑ 58% drospirenon Cmin NO drospirenon Cmax ↑ 15%
English: Concomitant administration of boosted darunavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity.
Croatian: Istodobna primjena pojačanog darunavira i kvetiapina je kontraindicirana jer može povisiti toksičnost povezanu s kvetiapinom.
English: Efavirenz in combination with boosted darunavir once daily may result in sub-optimal darunavir Cmin.
Croatian: Efavirenz u kombinaciji s pojačanim darunavirom jedanput na dan može rezultirati suboptimalnom vrijednošću Cmin darunavira.
English: If there is evidence of new or worsening liver dysfunction (including clinically significant elevation of liver enzymes and/or symptoms such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) in patients using darunavir used in combination with cobicistat or low dose ritonavir, interruption or discontinuation of treatment should be considered promptly.
Croatian: Ako postoje dokazi o novoj ili pogoršanju disfunkcije jetre (uključujući klinički značajno povišenje enzima jetre i/ili simptomi poput umora, anoreksije, mučnine, žutice, tamne mokraće, osjetljivosti jetre, hepatomegalije) u bolesnika koji uzimaju darunavir koji se uzima u kombinaciji s kobicistatom ili niskom dozom ritonavira, mora se odmah razmotriti privremeni ili trajni prekid liječenja.
English: Perphenazine Risperidone Thioridazine
Croatian: Perfenazin Risperidon Tioridazin
English: The pharmacokinetic properties of darunavir, co-administered with cobicistat or ritonavir, have been evaluated in healthy adult volunteers and in HIV-1 infected patients.
Croatian: Farmakokinetička svojstva darunavira primjenjenog istodobno s kobicistatom ili ritonavirom, ispitivana su u zdravih odraslih dobrovoljaca i u bolesnika inficiranih s HIV-1.
English: If parenteral midazolam is co-administered with boosted darunavir it may cause a large increase in the concentration of this benzodiazepine.
Croatian: Ako se parenteralni midazolam istodobno primjenjuje s pojačanim darunavirom to može izazvati velik porast koncentracija ovog benzodiazepina.
English: Take Darunavir Krkawith food.
Croatian: - Lijek Darunavir Krka uzimajte s hranom.
English: A dose decrease may be needed for these drugs when co-administered with boosted darunavir.
Croatian: Može biti potrebno smanjenje doze za te lijekove kada se primjenjuju istodobno s pojačanim darunavirom.
English: Other strengths of Darunavir Krka are available.
Croatian: Dostupne su druge jačine lijeka Darunavir Krka.
English: Although the effect on CYP2C8 has only been studied in vitro, co-administration of darunavir and ritonavir and medicinal products primarily metabolised by CYP2C8 (such as paclitaxel, rosiglitazone, repaglinide) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Croatian: Iako je učinak na CYP2C8 bio ispitivan samo in vitro, istodobna primjena darunavira i ritonavira i drugih lijekova koji se primarno metaboliziraju putem CYP2C8 (poput paklitaksela, rosiglitazona, repaglinida) može rezultirati smanjenom sistemskom izloženosti tim lijekovima, što može smanjiti ili skratiti njihov terapijski učinak.
English: Darunavir should not be used in paediatric patients below 3 years of age or less than 15 kg body weight (see sections 4.4 and 5.3).
Croatian: Darunavir se ne smije primjenjivati u pedijatrijskih bolesnika mlađih od 3 godine ili s manje od 15 kg tjelesne težine (vidjeti dijelove 4.4 i 5.3).
English: Darunavir contains a sulphonamide moiety.
Croatian: Darunavir sadrži sulfonamidnu funkcionalnu skupinu.
English: Boceprevir 800 mg three times daily boceprevir AUC ↓ 32% boceprevir Cmin ↓ 35% boceprevir Cmax ↓ 25% darunavir AUC ↓ 44% darunavir Cmin ↓ 59% darunavir Cmax ↓ 36%
Croatian: Boceprevir 800 mg triput na dan boceprevir AUC ↓ 32% boceprevir Cmin ↓ 35% boceprevir Cmax ↓ 25% darunavir AUC ↓ 44% darunavir Cmin ↓ 59% darunavir Cmax ↓ 36%
English: Darunavir binds primarily to plasma α1-acid glycoprotein.
Croatian: Darunavir se primarno veže na α1-kiseli glikoprotein plazme.
English: Darunavir Krka with cobicistat or ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Croatian: Darunavir Krka s kobicistatom ili ritonavirom nije bio ispitan sa svim IP (inhibitori proteaze) i ne smije se uzimati s drugim IP HIVa.
English: The overall pharmacokinetic enhancement effect by ritonavir was an approximate 14-fold increase in the systemic exposure of darunavir when a single dose of 600 mg darunavir was given orally in combination with ritonavir at 100 mg twice daily (see section 4.4).
Croatian: Ukupni učinak pospješenja farmakokinetike ritonavirom bio je približno 14 puta veća sistemska izloženost darunaviru, kad se jednokratna doza od 600 mg darunavira dala peroralno u kombinaciji sa 100 mg ritonavira dvaput na dan (vidjeti dio 4.4).
English: 375 milligram darunavir + 50 milligram ritonavir twice a day between 30 and 40 kilograms
Croatian: 375 miligrama darunavira + 50 miligrama ritonavira dvaput na dan između 30 i 40 kilograma
English: Darunavir co-administered with low dose ritonavir and etravirine 200 mg twice daily can be used without dose adjustments.
Croatian: Darunavir istodobno primijenjen s niskom dozom ritonavira i etravirinom 200 mg dvaput na dan može se primijeniti bez prilagodbe doze.
English: ART-experienced paediatric patients from the age of 3 to < 6 years The pharmacokinetics, safety, tolerability and efficacy of darunavir/ritonavir twice daily in combination with other antiretroviral agents in 21 ART-experienced HIV-1 infected paediatric patients aged 3 to < 6 years and weighing 10 kg to < 20 kg was evaluated in an open-label, Phase II trial, ARIEL.
Croatian: Pedijatrijski bolesnici prethodno liječeni ART-om u dobi od 3 do < 6 godina Farmakokinetika, sigurnost, podnošljivost i djelotovornost darunavira/ritonavira dvaput na dan u kombinaciji s drugim antiretrovirusnim lijekovima, procijenjene su u otvorenom ispitivanju ARIEL faze II, u 21 pedijatrijskog bolesnika prethodno liječenih ART-om inficiranih s HIV-1, u dobi od 3 do < 6 godina i težine 10 kg do < 20 kg.
English: Efavirenz in combination with darunavirmay result in sub-optimal darunavir Cmin.
Croatian: Efavirenz u kombinaciji s darunavirom može rezultirati suboptimalnom vrijednošću Cmin darunavira.
English: Blood and lymphatic system disorders uncommon thrombocytopenia, neutropenia, anaemia, leukopenia rare increased eosinophil count
Croatian: Poremećaji krvi i limfnog sustava manje često thrombocitopenija, neutropenija, anemija, leukopenija rijetko povišen broj eozinofila
English: Clinical monitoring is recommended when co-administering boosted darunavir with these antidepressants and a dose adjustment of the antidepressant may be needed.
Croatian: Preporučuje se kliničko praćanje kada se ti antidepresivi primjenjuju istodobno s pojačanim darunavirom, a može biti potrebna prilagodba doze antidepresiva.
English: This dose must not exceed the recommended adult dose, which is 600 milligram Darunavir Krka together with 100 milligram of ritonavir two times per day or 800 milligram Darunavir Krka together with 100 milligram ritonavir once a day.
Croatian: Ova doza ne smije prijeći preporučenu dozu za odrasle, koja je 600 miligrama lijeka Darunavir Krka zajedno sa 100 miligrama ritonavira dvaput na dan ili 800 miligrama lijeka Darunavir Krka zajedno sa 100 miligrama ritonavira jedanput na dan.
English: Voriconazole should not be combined with boosted darunavir unless an assessment of the benefit/risk ratio justifies the use of voriconazole.
Croatian: Vorikonazol se ne smije kombinirati s pojačanim darunavirom, osim ako se procijeni da omjer koristi i rizika opravdava primjenu vorikonazola.
English: Darunavir Krka with ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Croatian: Darunavir Krka s ritonavirom nije bio ispitan sa svim IP (inhibitori proteaze) i ne smije se uzimati s drugim IP HIV-a.
English: Concomitant use of darunavir/ritonavir and darunavir/cobicistat with lopinavir/ritonavir, rifampicin and herbal products containing St John's wort, Hypericum perforatum, is contraindicated (see section 4.5).
Croatian: Istodobna primjena darunavira/ritonavira i darunavira/kobicistata s lopinavirom/ritonavirom, rifampicinom i biljnim pripravcima koji sadrže gospinu travu, Hypericum perforatum, je kontraindicirana (vidjeti dio 4.5).
English: Based on theoretical considerations darunavir is expected to increase alfuzosin plasma concentrations.
Croatian: Temeljeno na teorijskim postavkama očekuje se da će darunavir povećati koncentracije alfuzozina u plazmi.
English: Bosentan is expected to decrease plasma concentrations of darunavir and/or its pharmacoenhancer.
Croatian: Za bosentan se očekuje da smanji koncentraciju darunavira i/ili njegovog farmakokinetičkog pojačivača. (CYP3A indukcija)
English: Darunavir and ritonavir are metabolised by CYP3A.
Croatian: Darunavir i ritonavir se metaboliziraju putem enzima CYP3A.