FrancophonIA/ELRC3.0 huggingface dataset:
English: A median of 1 dose of tocilizumab (range, 1-4 doses) was administered.
Croatian: Primijenjen je medijan od 1 doze tocilizumaba (raspon: 1 - 4 doze).
English: Age, gender and ethnicity: Population pharmacokinetic analyses in RA patients, showed that age, gender and ethnic origin did not affect the pharmacokinetics of tocilizumab.
Croatian: Dob, spol i etničko porijeklo: Ispitivanja populacijske farmakokinetike kod bolesnika s RA pokazala su da dob, spol i etničko porijeklo ne utječu na farmakokinetiku tocilizumaba.
English: Patients transitioning from intravenous to subcutaneous formulation should administer their first subcutaneous dose instead of the next scheduled intravenous dose under the supervision of a qualified healthcare professional.
Croatian: Bolesnici koji prelaze s intravenske na supkutanu formulaciju lijeka moraju prvu supkutanu dozu, koju primjenjuju umjesto sljedeće planirane intravenske doze, primijeniti pod nadzorom kvalificiranog zdravstvenog radnika.
English: The comparator group was weekly MTX (dose titrated from 7.5 mg to a maximum of 20 mg weekly over an eight week period).
Croatian: Skupinu za usporedbu činili su bolesnici koji su tjedno primali MTX (doza titrirana u rasponu od 7,5 mg do maksimalno 20 mg tjedno tijekom razdoblja od osam tjedana).
English: MANUFACTURER(S) OF THE BIOLOGICAL ACTIVE SUBSTANCE(S) AND MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Croatian: PROIZVOĐAČ(I) BIOLOŠKE(IH) DJELATNE(IH) TVARI I PROIZVOĐAČ(I) ODGOVORAN(ODGOVORNI) ZA PUŠTANJE SERIJE LIJEKA U PROMET
English: RoActemra monotherapy should not be used for the treatment of acute relapses as efficacy in this setting has not been established.
Croatian: RoActemra se ne smije primjenjivati u monoterapiji za liječenje akutnih relapsa jer nije utvrđena djelotvornost u tim uvjetima.
English: Restart with weekly or every other week injection, as clinically appropriate.
Croatian: Ponovno započeti liječenje primjenom injekcija jedanput tjedno ili jedanput svaka dva tjedna, prema kliničkoj potrebi.
English: RoActemra is used to improve the symptoms of sJIA.
Croatian: RoActemra se koristi za ublažavanje simptoma sJIA.
English: RoActemra can affect the way some medicines work, and the dose of these may require adjustment.
Croatian: RoActemra može utjecati na djelovanje nekih lijekova, možda će trebati prilagoditi njihovu dozu.
English: There are no adequate data from the use of tocilizumab in pregnant women.
Croatian: Nema odgovarajućih podataka o primjeni tocilizumaba kod trudnica.
English: Patients with severe or life-threatening CRS frequently have cytopenias or elevated ALT or AST due to the underlying malignancy, preceding lymphodepleting chemotherapy or the CRS.
Croatian: Bolesnici s teškim ili po život opasnim CRS-om često imaju citopenije ili povišene vrijednosti ALT-a odnosno AST-a zbog podležeće zloćudne bolesti, prethodne kemoterapije koja uzrokuje depleciju limfocita ili CRS-a.
English: Patients should inform their doctor immediately if they experience signs and symptoms of liver toxicity including tiredness, abdominal pain and jaundice.
Croatian: Bolesnici moraju odmah obavijestiti svog liječnika ako primijete znakove i simptome toksičnih učinaka na jetru, uključujući umor, bol u abdomenu i žuticu.
English: ACR20 Week 24 Weighted difference (95% CI) ACR50 Week 24 Weighted difference (95% CI) ACR70 Week 24 Weighted difference (95% CI)
Croatian: ACR20 nakon 24 tjedna Ponderirana razlika (95% CI) ACR50 nakon 24 tjedna Ponderirana razlika (95% CI) ACR70 nakon 24 tjedna Ponderirana razlika (95% CI)
English: • Place the pre-filled pen on a clean, flat surface and let the pre-filled pen warm up for 45 minutes to allow it to reach room temperature.
Croatian: · Položite napunjenu brizgalicu na čistu i ravnu površinu i pričekajte 45 minuta da se ugrije na sobnu temperaturu.
English: 79639 Grenzach-Wyhlen Germany
Croatian: 79639 Grenzach-Wyhlen
English: Patients with latent TB should be treated with standard anti-mycobacterial therapy before initiating RoActemra.
Croatian: Bolesnike s latentnom tuberkulozom treba liječiti standardnim antituberkuloticima (antimikobakterijskim lijekovima) prije nego što se započne s primjenom lijeka RoActemra.
English: followed by a 104-week open-label extension (Part 2).
Croatian: (1. dio), nakon kojega je uslijedio 104-tjedni otvoreni produžetak (2. dio).
English: Following subcutaneous dosing in GCA patients, the absorption t½ was around 4 days.
Croatian: Nakon supkutane primjene u bolesnika s GCA, poluvrijeme apsorpcije iznosilo je približno 4 dana.
English: • Monitoring of the patient for injection/infusion reactions
Croatian: · podatke o nadzoru bolesnika radi uočavanja reakcija na injekciju/infuziju
English: Study IV evaluated 1,220 patients who had an inadequate response to their existing rheumatologic therapy, including one or more DMARDs.
Croatian: U ispitivanju IV ocijenjeno je 1220 bolesnika s neprimjerenim odgovorom na postojeću reumatološku terapiju, uključujući jedan ili više DMARD-a.
English: • warfarin or phenprocoumon, used as a blood thinning agents
Croatian: · varfarin ili fenprokumon, za razrjeđivanje krvi
English: In the SC Study 5.8% [3/52] developed positive neutralizing anti-tocilizumab antibodies without developing a serious or clinically significant hypersensitivity reaction.
Croatian: U ispitivanju supkutane primjene kod 5,8% [3/52] bolesnika razvila su se neutralizirajuća protutijela na tocilizumab koja nisu bila praćena ozbiljnom ili klinički značajnom reakcijom preosjetljivosti.
English: The dose should be calculated based on the patient's body weight at each administration.
Croatian: Dozu je potrebno izračunati na temelju tjelesne težine bolesnika prije svake primjene.
English: Switching from 8 mg/kg intravenous once every 4 weeks to 162 mg subcutaneous once every week, will alter exposure in the patient.
Croatian: Prelazak s intravenske doze od 8 mg/kg jedanput svaka 4 tjedna na supkutanu dozu od 162 mg jedanput tjedno promijenit će izloženost bolesnika lijeku.
English: Keep the RoActemra syringe and all medicines out of the sight and reach of children.
Croatian: RoActemra štrcaljku i sve druge lijekove čuvajte izvan pogleda i dohvata djece.
English: Do not inject RoACTEMRA if the liquid is cloudy, discolored, or has lumps or particles in it because it may not be safe to use.
Croatian: Nemojte injicirati lijek RoACTEMRA ako je tekućina mutna, ako je promijenila boju ili ako sadrži grudice ili čestice, jer možda nije sigurna za uporabu.
English: The expression of hepatic CYP450 enzymes is suppressed by cytokines, such as IL-6, that stimulate chronic inflammation.
Croatian: Ekspresiju jetrenih enzima CYP450 smanjuju citokini poput IL-6, koji su medijatori kronične upale.
English: At steady-state following a dose of 8 mg/kg every 4 weeks, the effective t1/2 decreased with decreasing concentrations within a dosing interval from 18 days to 6 days.
Croatian: U stanju dinamičke ravnoteže nakon doze od 8 mg/kg svaka 4 tjedna, vrijednost efektivnog t1/2 opadala je sa smanjenjem koncentracije unutar intervala doziranja od 18 do 6 dana.
English: RoActemra is supplied in a vial (type I glass) with a stopper (butyl rubber) containing 4 mL, 10 mL or 20 mL concentrate.
Croatian: RoActemra je dostupna u bočici (staklo tipa I) s čepom (butilna guma) koja sadrži koncentrat u količini od 4 ml, 10 ml ili 20 ml.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity and toxicity to reproduction and development.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti te reproduktivne i razvojne toksičnosti.
English: • theophylline, used to treat asthma
Croatian: · teofilin, za liječenje astme
English: The primary endpoint was the proportion of patients with at least 30% improvement in the JIA ACR core set (JIA ACR30 response) at week 12 and absence of fever (no temperature recording ≥ 37.5°C in the preceding 7 days).
Croatian: Primarna mjera ishoda bila je odrediti udio bolesnika s najmanje 30-postotnim poboljšanjem stanja prema kriteriju JIA ACR (odgovor JIA ACR30) nakon 12 tjedana i bez pojave vrućice (bez zabilježene temperature ≥ 37,5 °C u prethodnih sedam dana).
English: TCZ SC 162 mg every week + DMARD N=558
Croatian: TCZ s.c. 162 mg jedanput tjedno + DMARD N=558
English: What do I need to know to use my RoActemra pre-filled syringe safely?
Croatian: Što moram znati za sigurnu uporabu RoActemra napunjene štrcaljke?
English: Study III evaluated 623 patients who had an inadequate clinical response to MTX.
Croatian: Ispitivanje III uključilo je 623 bolesnika s neprimjerenim kliničkim odgovorom na MTX.
English: What RoActemra looks like and contents of the pack RoActemra is a concentrate for solution for infusion.
Croatian: Kako RoActemra izgleda i sadržaj pakiranja RoActemra je koncentrat za otopinu za infuziju.
English: The efficacy of tocilizumab was assessed in a three-part study WA19977 including an open-label extension in children with active pJIA.
Croatian: Klinička djelotvornost Djelotvornost tocilizumaba ispitana je u trodijelnom ispitivanju WA19977, uključujući i otvoreni produžetak ispitivanja, kod djece s aktivnim pJIA. Dio
English: If the needle cap is removed for more than 5 minutes, it may be more difficult to perform an injection as the medicine can dry out and block the needle.
Croatian: Ako je od skidanja zatvarača igle prošlo više od 5 minuta, moguće je da će injiciranje biti teže jer se lijek može osušiti i začepiti iglu.
English: The most commonly reported ADRs (occurring in ≥ 5% of patients treated with tocilizumab monotherapy or in combination with DMARDs) were upper respiratory tract infections, nasopharyngitis, headache, hypertension and increased ALT.
Croatian: Najčešće prijavljene nuspojave (pojavljuju se u ≥ 5% bolesnika liječenih tocilizumabom u monoterapiji ili u kombinaciji s DMARD-ovima) bile su infekcije gornjeg dišnog sustava, nazofaringitis, glavobolja, hipertenzija i povišene vrijednosti ALT-a.
English: However, if you are worried, talk to your doctor.
Croatian: Međutim, ako ste zabrinuti, obratite se svom liječniku,
English: Approximately one-third of the patients in the GCA study had moderate renal impairment at baseline (estimated creatinine clearance of 30-59 mL/min).
Croatian: Približno jedna trećina bolesnika u ispitivanju primjene kod GCA imala je umjereno oštećenje bubrežne funkcije na početku liječenja (procijenjeni klirens kreatinina: 30 - 59 ml/min).
English: • Use your other hand to gently pinch the area of skin you cleaned, to prepare a firm injection site (See Figure G).
Croatian: · Drugom rukom nježno uhvatite očišćeni dio kože, kako biste pripremili čvrsto mjesto za injiciranje (vidjeti Sliku G).
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije detaljno objašnjene u dogovorenom Planu upravljanja rizikom (RMP), koji se nalazi u Modulu 1.8.2
English: At one year in the open label extension phase the overall rate of serious infections remained stable at 11.3 per 100 patient years.
Croatian: Jednu godinu nakon početka otvorene faze produžetka ispitivanja, ukupna se stopa ozbiljnih infekcija zadržala na stabilnoj razini od 11,3 na 100 bolesnik-godina.
English: Patient advice regarding early recognition and treatment to limit risk of a serious infection
Croatian: Savjeti za bolesnike o ranom prepoznavanju i liječenju radi ograničavanja rizika od ozbiljne infekcije Pripazite na prve znakove infekcije, poput:
English: No correlation between antibody development and clinical response or adverse events was observed
Croatian: Nije opažena korelacija između razvoja protutijela i kliničkog odgovora ili štetnih događaja.
English: • Place the syringe on a clean flat surface and allow the syringe to come to room temperature (18°C - 28°C) for about 25-30 minutes to warm up.
Croatian: · Štrcaljku položite na čistu ravnu površinu i pričekajte približno 25-30 minuta da se ugrije na sobnu temperaturu (18°C - 28°C).
English: Patients included in the trial had a total disease duration of at least 6 months and active disease but were not experiencing an acute flare requiring corticosteroid doses of more than 0.5 mg/kg prednisone equivalent.
Croatian: Ispitivanje je obuhvatilo bolesnike s aktivnom bolešću, kod kojih je ona ukupno trajala barem 6 mjeseci, ali koji nisu imali akutizacije (acute flare) koje su zahtijevale terapiju kortikosteroidima u dozi većoj 0,5 mg/kg ekvivalenta prednizona.
English: Patients should be advised to immediately seek medical help if they experience signs and symptoms of hepatic injury.
Croatian: Bolesnike je potrebno uputiti da odmah potraže liječničku pomoć ako se pojave znakovi i simptomi oštećenja jetre.
English: Parents and carers will get training on how to inject RoActemra for patients who cannot inject themselves, such as children.
Croatian: Obuku o tome kako injicirati lijek RoActemra proći će i roditelji i njegovatelji bolesnika koji ne mogu samostalno injicirati lijek, kao što su djeca.
English: These ISRs occurred in a 44% of patients ≥30 kg compared to 14.8% of patients below 30 kg.
Croatian: Te su se reakcije javile kod 44% bolesnika tjelesne težine ≥ 30 kg u usporedbi s 14,8% bolesnika tjelesne težine manje od 30 kg.
English: The developed model had the same structure as the population PK model developed earlier based on data from RA patients (see Table 8).
Croatian: Razvijeni model imao je istu strukturu kao i populacijski farmakokinetički model razvijen ranije na temelju podataka prikupljenih u bolesnika s RA (vidjeti Tablicu 8).
English: Study WA28119 was a randomized, multi-center, double-blind placebo-controlled Phase III superiority study conducted to assess the efficacy and safety of RoActemra in patients with GCA.
Croatian: Klinička djelotvornost Ispitivanje WA28119 bilo je randomizirano, multicentrično, dvostruko slijepo, placebom kontrolirano ispitivanje superiornosti faze III provedeno radi ocjene djelotvornosti i sigurnosti lijeka RoActemra u bolesnika s GCA.
English: • Always keep the puncture-resistant container out of the sight and reach of children.
Croatian: · Neprobojan spremnik uvijek čuvajte izvan pogleda i dosega djece.
English: The developed model had the same structure as the population PK model developed earlier based on data from RA patients (see Table 10).
Croatian: Razvijeni model imao je istu strukturu kao i populacijski farmakokinetički model razvijen ranije na temelju podataka prikupljenih u bolesnika s RA (vidjeti Tablicu 10).
English: The needle shield will then move out and lock into place covering the needle (See Figure L).
Croatian: Tada će izaći zaštitni pokrov igle, koji će prekriti iglu i zaključati se (vidjeti Sliku L).
English: RoActemra subcutaneous formulation is not intended for intravenous administration.
Croatian: Supkutana formulacija lijeka RoActemra nije namijenjena za intravensku primjenu.
English: One patient in the 10 mg/kg < 30kg group developed positive anti-tocilizumab antibodies without developing a hypersensitivity reaction and subsequently withdrew from the study.
Croatian: Kod jednog bolesnika u skupini tjelesne težine < 30 kg koji je primao dozu od 10 mg/kg razvila su se pozitivna protutijela na tocilizumab, ali se pritom nije pojavila reakcija preosjetljivosti; bolesnik se nakon toga povukao iz ispitivanja.
English: It is important to choose the correct angle to ensure the medication is delivered under the skin (into fatty tissue), otherwise the injection could be painful and the medication may not work.
Croatian: Važno je iglu ubosti pod odgovarajućim kutom kako bi se osigurala primjena lijeka pod kožu (u masno tkivo) jer bi u suprotnom injekcija mogla biti bolna, a lijek nedjelotvoran.
English: • The outer area of the upper arms may also be used only if the injection is being given by a caregiver.
Croatian: · Lijek se može injicirati i u vanjski dio nadlaktice, ali samo ako injekciju daje skrbnik.
English: The incidence of anti-tocilizumab antibody formation might be underestimated because of interference of tocilizumab with the assay and higher drug concentration observed in children compared to adults.
Croatian: Incidencija stvaranja protutijela na tocilizumab možda je podcijenjena zbog utjecaja tocilizumaba na nalaze pretrage te veće zabilježene koncentracije lijeka u djece u odnosu na odrasle.
English: Continued durable responses were seen for over 3 years in the ongoing open label extension studies I-V.
Croatian: Dugotrajni odgovori održani su tijekom više od 3 godine u otvorenim produžecima ispitivanja I-V, koji još traju.
English: At week 12, the proportion of tocilizumab treated patients showing a minimally clinically important improvement in the Childhood Health Assessment Questionnaire - Disability Index (defined as an individual total score decrease of ≥ 0.13) was significantly higher than in placebo treated patients, 77% versus 19% (p<0.0001).
Croatian: Udio bolesnika liječenih tocilizumabom koji su nakon 12 tjedana pokazivali minimalno klinički značajno poboljšanje prema Upitniku za procjenu zdravlja djece - indeksu onesposobljenosti (definirano kao pojedinačno smanjenje ukupne ocjene ≥ 0,13) bio je značajno veći od udjela bolesnika koji su primali placebo, odnosno 77% naspram 19% (p<0,0001).
English: To mix the solution, gently invert the infusion bag to avoid foaming.
Croatian: Da bi se otopina promiješala, infuzijsku vrećicu treba nježno okrenuti kako bi se izbjeglo stvaranje pjene.
English: Once removed from the refrigerator, RoActemra must be administered within 8 hours and should not be kept above 30°C.
Croatian: Kada se izvadi iz hladnjaka, RoActemra se mora primijeniti unutar 8 sati i ne smije se čuvati na temperaturi iznad 30°C.
English: Of the 4009 patients in this population, 3577 received treatment for at least 6 months, 3296 for at least one year, 2806 received treatment for at least 2 years and 1222 for 3 years.
Croatian: Od 4009 bolesnika u toj populaciji, njih 3577 bilo je liječeno najmanje 6 mjeseci, 3296 najmanje jednu godinu, 2806 najmanje 2 godine, a njih 1222 tri godine.
English: No (N = 55)
Croatian: Ne (N = 55)
English: Since RoActemra is given by a doctor or nurse, it is unlikely that you will miss a dose.
Croatian: Budući da lijek RoActemra primjenjuju liječnik ili medicinska sestra, mala je vjerojatnost da ćete propustiti dozu.
English: However, doses below 1025 mg of this medicine contain less than 23 mg sodium, so they are virtually sodium free.
Croatian: Međutim, doze manje od 1025 mg ovog lijeka sadrže manje od 23 mg natrija, tj. zanemarive količine natrija.
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with RoActemra should be made taking into account the benefit of breast-feeding to the child and the benefit of RoActemra therapy to the woman.
Croatian: Odluku o nastavku ili prekidu dojenja odnosno nastavku ili prekidu liječenja lijekom RoActemra treba donijeti uzimajući u obzir korist dojenja za dijete i korist liječenja lijekom RoActemra za ženu.
English: You should not stop using RoActemra without discussing with your doctor first.
Croatian: Ne smijete prekinuti liječenje lijekom RoActemra bez prethodnog dogovora s liječnikom.
English: Reported serious infections, some with fatal outcome, included pneumonia, cellulitis, herpes zoster, gastroenteritis, diverticulitis, sepsis, bacterial arthritis.
Croatian: Prijavljene ozbiljne infekcije, od kojih su neke imale smrtni ishod, uključivale su pneumoniju, celulitis, herpes zoster, gastroenteritis, divertikulitis, sepsu i bakterijski artritis.
English: 2 See section 4.4
Croatian: 1 Vidjeti dio 4.3 2 Vidjeti dio 4.4
English: Additionally, proliferative lesions were not observed in a 6-month chronic toxicity study in cynomolgus monkeys or in IL-6 deficient mice.
Croatian: Također, proliferativne lezije nisu opažene ni u šestomjesečnom ispitivanju kronične toksičnosti u cinomolgus majmuna i miševa s deficijencijom IL-6.
English: • Wash your hands with soap and water.
Croatian: 3. korak: Operite ruke · Operite ruke sapunom i vodom.
English: • Pinching the skin is important to make sure that you inject under the skin (into fatty tissue) but not any deeper (into muscle).
Croatian: · Hvatanje nabora kože važno je kako biste bili sigurni da ste lijek injicirali pod kožu (u masno tkivo), ali ne dublje (u mišić).
English: Of the 46 patients (1.6%) who developed anti-tocilizumab antibodies, 6 had an associated medically significant hypersensitivity reaction, of which 5 led to permanent discontinuation of treatment.
Croatian: Od 46 bolesnika (1,6%) u kojih su se razvila protutijela na tocilizumab, 6 ih je imalo s time povezanu medicinski značajnu reakciju preosjetljivosti, zbog čega je u njih 5 liječenje moralo biti trajno prekinuto.
English: What RoActemra is and what it is used for What you need to know before you use RoActemra How to use RoActemra
Croatian: Što je RoActemra i za što se koristi Što morate znati prije nego počnete primati lijek RoActemra Kako primjenjivati lijek RoActemra
English: RoActemra contains sodium
Croatian: RoActemra sadrži natrij
English: • 1 Puncture-resistant container or sharps container for safe disposal of pre-filled pen cap and used pre-filled pen (see Step 4 “Dispose of the pre-filled pen”)
Croatian: · 1 neprobojan spremnik ili spremnik za oštre predmete, za sigurno odlaganje zatvarača napunjene brizgalice i upotrijebljene brizgalice (vidjeti 4. korak ‘Zbrinite napunjenu brizgalicu')
English: In a separate analysis of the patients who received escape prednisone to treat GCA flare during the first 52 weeks, the cumulative prednisone dose varied greatly.
Croatian: U zasebnoj analizi bolesnika koji su tijekom prva 52 tjedna primali dodatne doze prednizona za liječenje epizode razbuktavanja GCA, kumulativna doza prednizona uvelike je varirala.
English: If a child has a history of macrophage activation syndrome (activation and uncontrolled proliferation of specific blood cells), tell your doctor.
Croatian: Ako je dijete u prošlosti imalo sindrom aktivacije makrofaga (aktivaciju i nekontrolirano povećanje broja određenih krvnih stanica), obavijestite o tome liječnika.
English: In this statistical analysis, patients who flared (and escaped to TCZ) during Part II or who withdrew, were classified as non-responders.
Croatian: U toj su statističkoj analizi bolesnici koji su u II. dijelu doživjeli pogoršanje upale (i prešli na liječenje tocilizumabom) ili oni koji su se povukli iz ispitivanja, svrstani u kategoriju bolesnika bez odgovora.
English: Very rare side effects: These may affect up to 1 in every 10,000 patients
Croatian: Vrlo rijetke nuspojave Mogu se javiti u do 1 na 10 000 bolesnika
English: RoActemra can be used alone or in combination with MTX.
Croatian: RoActemra se može primjenjivati samostalno ili u kombinaciji s MTX-om.
English: The usual dose of RoActemra is 8 mg for every kg of body weight if you weigh 30 kg or more.
Croatian: Uobičajena doza lijeka RoActemra iznosi 8 mg po svakom kilogramu tjelesne težine ako je tjelesna težina 30 kg ili više.
English: In the tocilizumab all exposure population, 11 patients (5.9%) experienced infusion reactions during the infusion and 38 patients (20.2%) experienced an event within 24 hours of an infusion.
Croatian: U cjelokupnoj populaciji izloženoj tocilizumabu, kod 11 su se bolesnika (5,9%) reakcije na infuziju javile tijekom infuzije, a kod njih 38 (20,2%) unutar
English: IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T- and B-cells, monocytes and fibroblasts.
Croatian: IL-6 je pleiotropni proupalni citokin koji proizvode razne vrste stanica, uključujući T i B stanice, monocite i fibroblaste.
English: • Put your used RoACTEMRA pre-filled pen and green cap in a sharps disposal container right away after use (See Figure M).
Croatian: · Odložite upotrijebljenu RoACTEMRA napunjenu brizgalicu i zeleni zatvarač u spremnik za oštre predmete odmah nakon primjene (vidjeti Sliku M).