FrancophonIA/ELRC3.0 huggingface dataset:
English: • the liquid is coloured or you can see particles floating in it
Danish: • væsken har farve, eller man kan se partikler flyde omkring i den
English: Adult surgery patients in an autologous predonation programme
Danish: Voksne patienter i et autologt prædonationsprogram
English: Included were 228 epoetin alfa-treated CRF subjects in 4 chronic renal failure studies (2 studies in predialysis [N = 131 exposed CRF subjects] and 2 in dialysis [N = 97 exposed CRF subjects]); 1 404 exposed cancer subjects in 16 studies of anaemia due to chemotherapy; 147 exposed subjects in 2 studies for autologous blood donation; 213 exposed subjects in 1 study in the perisurgical period, and 102 exposed subjects in 2 MDS studies.
Danish: Der deltog 228 epoetin alfa-behandlede forsøgspersoner med kronisk nyresvigt i 4 studier af kronisk nyresvigt (2 studier i prædialyse [N=131 eksponerede forsøgspersoner med kronisk nyresvigt] og 2 i dialyse [N=97 eksponerede forsøgspersoner med kronisk nyresvigt]; 1 404 eksponerede forsøgspersoner med cancer i 16 studier af anæmi på grund af kemoterapi; 147 eksponerede forsøgspersoner i 2 studier af autolog bloddonation; 213 eksponerede forsøgspersoner i 1 studie i perioden omkring det kirurgiske indgreb, og 102 eksponerede forsøgspersoner i 2 MDS-studier.
English: The haemoglobin concentration aimed for is between 10 and 12 g/dl (6.2-7.5 mmol/l), except in paediatric patients in whom the haemoglobin concentration should be between 9.5 and 11 g/dl (5.9-6.8 mmol/l).
Danish: Der tilstræbes en hæmoglobinkoncentration på mellem 10 og 12 g/dl (6,2-7,5 mmol/l) undtaget hos pædiatriske patienter, hvis hæmoglobinkoncentration bør ligge mellem 9,5 og 11 g/dl (5,96,8mmol/l).
English: Cytotoxic actions of erythropoietin on bone marrow cells could not be detected.
Danish: Der kunne ikke detekteres cytotoksiske virkninger af erythropoietin på knoglemarvsceller.
English: o Treatment of severe anaemia of renal origin accompanied by clinical symptoms in adult patients with renal insufficiency not yet undergoing dialysis (see section 4.4).
Danish: o Behandling af alvorlig anæmi af renal oprindelse ledsaget af kliniske symptomer hos voksne patienter med renal insufficiens, som endnu ikke er i dialyse (se pkt.
English: An open-label, parallel-group trial in non-iron deficient adult subjects with a pretreatment haemoglobin of ≥ 10 to ≤ 13 g/dl who were scheduled for major orthopaedic hip or knee surgery compared epoetin alfa 300 IU/kg subcutaneously daily for 10 days prior to surgery, on the day of surgery and for four days after surgery to epoetin alfa 600 IU/kg subcutaneously once weekly for 3 weeks prior to surgery and on the day of surgery.
Danish: I et åbent, parallelgruppestudie med voksne forsøgspersoner uden jernmangel og med hæmoglobin på ≥10 til ≤13 g/dl, som skulle gennemgå en planlagt større ortopædisk hofte- eller knæoperation, blev epoetin alfa 300 IE/kg subkutant dagligt i 10 dage før operationen, på operationsdagen og i 4 dage efter operationen sammenlignet med epoetin alfa 600 IE/kg subkutant ugentligt i 3 uger før operationen og på operationsdagen.
English: If no cause is identified, a bone marrow examination should be considered for diagnosis of PRCA.
Danish: Hvis der ikke identificeres nogen årsag, bør en knoglemarvsundersøgelse overvejes.
English: Silapo should be administered either under the skin (subcutaneously) or as an injection either into a vein or a tube that goes into a vein.
Danish: Silapo bør gives enten under huden (subkutant) eller som en injektion i en blodåre (vene) eller i en slange, som føres ind i en blodåre (vene).
English: Screening sEPO <200 mU/ml (N) Haemoglobin (g/l)
Danish: Total (N) sEPO ved screening < 200 mE/ml (N) Hæmoglobin (g/l)
English: Baseline Characteristics for Subjects with sEPO<200 mU/ml at Screening Randomised
Danish: Baselinekarakteristika for patienter med sEPO < 200 mE/ml ved screening Randomiseret
English: A minimum of 4 weeks should elapse between dose increases.
Danish: Der skal gå mindst 4 uger mellem dosisøgninger.
English: Meta-analysis of overall survival data produced a hazard ratio point estimate of 1.08 in favour of controls (95% CI: 0.99, 1.18; 42 trials and 8 167 patients).
Danish: Metaanalyse af data for samlet overlevelse gav et estimat af hazard ratio på 1,08 til fordel for kontrolgruppen (95% konfidensinterval: 0,99, 1,18; 42 undersøgelser og 8 167 patienter).
English: The maximum dosage should not exceed 150 IU/kg 3 times per week, 240 IU/kg (up to a maximum of 20 000 IU) once weekly or 480 IU/kg (up to a maximum of 40 000 IU) once every 2 weeks.
Danish: Den maksimale dosering bør ikke overstige 150 IE/kg 3 gange om ugen, 240 IE/kg (op til maksimalt 20 000 IE) en gang ugentligt eller 480 IE/kg (op til maksimalt 40 000 IE) en gang hver 2. uge.
English: The symptoms are: o unusual tiredness, o feeling dizzy, o breathlessness.
Danish: Symptomerne er; o usædvanlig træthed, o svimmelhed, o åndenød.
English: The recommended dose is 600 IU/kg administered subcutaneously weekly for three weeks (days -21,14 and -7) prior to surgery and on the day of surgery.
Danish: Den anbefalede dosis Silapo er 600 IE/kg, der administreres subkutant 1 gang om ugen i 3 uger (på dag 21, 14 og 7) forud for operationsdagen samt på selve operationsdagen.
English: Extending dose intervals may require an increase in dose.
Danish: Længere dosisintervaller kan kræve dosisøgning.
English: You will also take iron supplements before and during Silapo treatment to increase the effectiveness of Silapo.
Danish: De vil også skulle tage jerntilskud før og under Silapo-behandlingen for at øge virkningen af Silapo.
English: Meta-analysis of overall survival data produced a hazard ratio point estimate of 1.06 in favour of controls (95% CI: 1.00, 1.12; 53 trials and 13 933 patients) and for the cancer patients receiving chemotherapy, the overall survival hazard ratio was 1.04 (95% CI: 0.97, 1.11; 38 trials and 10 441 patients).
Danish: En meta-analyse af data vedrørende den samlede overlevelse frembragte en relativ risiko (hazard ratio) på 1,06 til fordel for kontrolgruppen (95 % CI: 1.00; 1,12; 53 undersøgelser og 13 933 patienter), og for de cancerpatienter, der modtog kemoterapi, var den samlede overlevelses-risikoratio 1,04 (95% CI: 0.97, 1.11; 38 undersøgelser og 10 441 patienter).
English: For patients scheduled for major elective orthopaedic surgery, iron supplementation (elemental iron 200 mg/day orally) should be administered throughout the course of epoetin zeta therapy.
Danish: Til patienter, der skal gennemgå planlagt større elektiv ortopædkirurgi, bør der gives jerntilskud (elementært jern 200 mg/dag oralt) under hele forløbet af epoetin zeta-behandlingen.
English: At a rate of rise in haemoglobin of > 2 g/dl (> 1.25 mmol/l) per month the Silapo dose should be reduced by about 25-50%.
Danish: Ved en hæmoglobinstigningsrate på > 2 g/dl (> 1,25 mmol/l) om måneden skal Silapo-dosis reducees med ca. 25-50 %.
English: In clinical trials, an increased risk of death, serious cardiovascular events or cerebrovascular events including stroke were observed when ESAs were administered to target a haemoglobin of greater than 12 g/dl (7.5 mmol/l).
Danish: I kliniske forsøg blev der observeret en øget risiko for død, alvorlige kardiovaskulære eller cerebrovaskulære hændelser, herunder apopleksi, når ESA'er blev administreret for at opnå en hæmoglobinkoncentration højere end 12 g/dl (7,5 mmol/l).
English: Silapo is used in adults, children and adolescents on haemodialysis to treat symptomatic anaemia (low red blood cell counts) associated with chronic renal failure (kidney disease).
Danish: Silapo anvendes til voksne, børn og unge i hæmodialyse til behandling af symptomatisk blodmangel (et lavt antal røde blodlegemer) forbundet med kronisk nyresygdom.
English: From pretreatment to presurgery, the mean increase in haemoglobin in the 600 IU/kg weekly group (1.44 g/dl) was twice than that observed in the 300 IU/kg daily group (0.73 g/dl).
Danish: Fra før behandlingen til før operationen var middelstigningen i hæmoglobin i gruppen, der fik 600 IE/kg ugentligt (1,44 g/dl), dobbelt så stor som observeret i gruppen, der fik 300 IE/kg dagligt (0,73 g/dl).
English: If an elevated (or rising) serum potassium level is detected then consideration should be given to ceasing erythropoietin administration until hyperkalaemia has been corrected.
Danish: (eller stigende) serum-kaliumniveau, skal det overvejes at ophøre med administrationen af erythropoietin, indtil hyperkalæmien er korrigeret.
English: Raised blood pressure may require treatment with medicines (or adjustment to any medicines you already take for high blood pressure).
Danish: • Blodtryksstigning, som måske kan kræve behandling med medicin (eller justering af medicin, som De allerede tager for for højt blodtryk).
English: Use in adult patients with kidney disease but not receiving dialysis The recommended starting dose is 50 IU/kg.
Danish: Anvendelse til voksne nyrepatienter, der ikke er i dialyse Den anbefalede startdosis er 50 IE/kg.
English: 300 IU/kg 3x/week for 4 weeks
Danish: 300 IE/kg 3 gange ugentligt i 4 uger
English: 25 and 50 IU/kg 2 times per week into 2 equal doses.
Danish: Vedligeholdelsesdosis mellem 25 og 50 IE/kg 2 gange om ugen i 2 lige store injektioner.
English: The safety and efficacy of epoetin zeta in paediatrics have not been established.
Danish: Sikkerhed og virkning af Silapo hos børn er ikke klarlagt.
English: • The blister sealing is broken or the blister is damaged in any way.
Danish: • blisterpakningens forsegling er brudt, eller blisterpakningen på nogen måde er beskadiget
English: If you experience headaches, particularly sudden, stabbing migraine-like headaches or start to feel confused or have fits, tell your doctor or nursing staff immediately.
Danish: Hvis De oplever hovedpine, især i pludselige, migrænelignende jag, eller begynder at føle Dem forvirret eller at få krampeanfald, skal De straks sige det til Deres læge eller til plejepersonalet.
English: In addition, special precaution should be taken in patients with predisposition for development of DVTs.
Danish: Desuden skal der træffes særlige forholdsregler hos patienter med disposition for udvikling af dyb venetrombose (DVT).
English: Treatment of anaemia and reduction of transfusion requirements in adult patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy).
Danish: Behandling af anæmi og reduktion af transfusionsbehov hos voksne patienter i kemoterapi for massive tumorer, malignt lymfom eller multipelt myelom og med risiko ved transfusion vurderet ud fra patientens almentilstand (fx kardiovaskulær tilstand, præeksisterende anæmi ved kemoterapistart).
English: In patients with a poor haemoglobin response to epoetins, alternative explanations for the poor response should be considered (see sections 4.2 and 5.1).
Danish: Hos patienter med dårlig hæmoglobinrespons på epoetiner, bør alternative forklaringer på den dårlige respons overvejes (se pkt.
English: Pure Red Cell Aplasia (PRCA) has been reported very rarely after months to years of subcutaneous treatment with other products containing erythropoietins and may not be ruled out with Silapo.
Danish: Der har i sjældne tilfælde forekommet Pure Red Cell Aplasia (PRCA) efter måneders eller års behandling med andre produkter, som indeholder erythropoietiner, og dette kan heller ikke udelukkes for Silapos vedkommende.
English: All patients being treated with Silapo should receive adequate iron supplementation (e.g. 200 mg oral elemental iron daily) throughout the course of treatment.
Danish: Alle patienter, som behandles med Silapo, bør have et tilstrækkeligt jerntilskud (fx 200 mg usammensat jern oralt dagligt) under hele behandlingen.
English: Adult and paediatric haemodialysis patients, adult peritoneal dialysis patients and adult patients with renal insufficiency not yet undergoing dialysis
Danish: Voksne og pædiatriske hæmodialysepatienter, voksne peritoneal-dialysepatienter og voksne med nyreinsufficiens, der endnu ikke er i dialyse
English: Arthralgia, Bone pain, Myalgia, Pain in extremity
Danish: Artralgi, knoglesmerter, myalgi, smerter i ekstremitet
English: Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients: o Treatment of anaemia associated with chronic renal failure in adult and paediatric patients on haemodialysis and adult patients on peritoneal dialysis (see section 4.4).
Danish: Behandling af symptomatisk anæmi forbundet med kronisk nyreinsuficiens hos voksne og pædiatriske patienter: o Behandling af anæmi associeret med kronisk nyresvigt hos voksne og pædiatriske patienter i hæmodialyse og voksne patienter i peritonealdialyse (se pkt.
English: A rise in haemoglobin of greater than 2 g/dl (1.25 mmol/l) over a four week period should be avoided.
Danish: En stigning i hæmoglobin på mere en 2 g/dl (1,25 mmol/l) over en 4 ugers periode bør undgås.
English: The clinical data available suggest that those patients whose initial haemoglobin is very low (< 6 g/dl or < 3.75 mmol/l) may require higher maintenance doses than those whose initial anaemia is less severe (Hb > 8 g/dl or > 5 mmol/l).
Danish: De tilgængelige kliniske data tyder på, at patienter med meget lavt initialt hæmoglobin (< 6 g/dl eller < 3,75 mmol/l) kan kræve højere vedligeholdelsesdoser end patienter med mindre alvorlig initial anæmi (Hb > 8 g/dl or > 5 mmol/l).
English: Particular attention should be paid to sudden stabbing migraine like headaches as a possible warning signal.
Danish: Der bør udvises særlig opmærksomhed over for pludseligt indsættende stikkende og migrænelignende hovedpine, da dette kan være et muligt forvarselstegn.
English: Special warnings
Danish: Særlige advarsler
English: Attention should be paid to sudden stabbing migraine-like headaches as a possible warning signal.
Danish: Der bør udvises opmærksomhed over for pludseligt indsættende stikkende og migrænelignende hovedpine, da dette kan være et muligt forvarselstegn.
English: • Flu-like symptoms, such as headache, aches and pains in the joints, feeling of weakness, chills, tiredness and dizziness.
Danish: • Influenzalignende symptomer, f.eks hovedpine, smertende og ømme led, mathed, kulderystelser, træthed og svimmelhed.
English: The protective cap is removed from the injection needle and air is expelled from the syringe and needle by holding the syringe vertically and gently pressing the plunger upwards.
Danish: Beskyttelseshætten tages af sprøjtens nål, og luften presses ud af sprøjten og nålen ved at holde sprøjten vertikalt og forsigtigt trykke stemplet opad.
English: In two large, open-label studies, 2 697 cancer patients receiving non-platinum chemotherapy were included, 1 895 with solid tumours (683 breast, 260 lung, 174 gynaecological, 300 gastrointestinal, and 478 other tumour types) and 802 with haematological malignancies.
Danish: I to store åbne undersøgelser deltog 2 697 cancerpatienter i behandling med ikke-platinbaseret kemoterapi, heraf 1 895 med massive tumorer (683 med bryst-, 260 med lunge, 174 med gynækologiske, 300 med gastrointetinale og 487 med andre typer tumorer) og 802 med hæmatologiske maligniteter.
English: • shortened overall survival and increased deaths attributed to disease progression at 4 months in patients with metastatic breast cancer receiving chemotherapy when administered to target a haemoglobin of 12-14 g/dl (7.5 -8.7 mmol/l),
Danish: • kortere samlet overlevelse og flere dødsfald, som tilskrives sygdomsprogression ved 4 måneder hos patienter med metastatisk brystcancer, som får kemoterapi, når stofferne gives for at tilstræbe et hæmoglobinniveau på 12-14 g/dl (7,5-8,7 mmol/l),
English: Your doctor may monitor your blood pressure regularly while you are using Silapo, particularly at the start of therapy.
Danish: Deres læge vil måske kontrollere Deres blodtryk regelmæssigt, mens De tager Silapo, specielt i starten af behandlingen.
English: Adult patients with renal insufficiency not yet undergoing dialysis
Danish: Voksne patienter med nyreinsufficiens, der endnu ikke er i dialyse
English: in adult patients with renal insufficiency not yet on dialysis to treat severe anaemia associated with kidney disease accompanied by clinical symptoms.
Danish: til voksne patienter med nedsat nyrefunktion, som endnu ikke er i dialyse, til behandling af alvorlig blodmangel forbundetmed nyresygdom ledsaget af kliniske symptomer.
English: If you are on a more extended dosing interval (greater than once weekly) of Silapo, you may not maintain adequate haemoglobin levels and you may require an increase in Silapo dose or frequency of administration.
Danish: Hvis der er længere interval mellem doserne (længere end en uge), er det ikke sikkert, at De opretholder et tilstrækkeligt hæmoglobinniveau, og det kan være nødvendigt at øge Silapodosis eller give injektionerne hyppigere.
English: Sodium hydroxide (pH adjuster) Hydrochloric acid (pH adjuster)
Danish: Vand til injektionsvæsker Natriumhydroxid (til justering af pH) Saltsyre (til justering af pH)
English: In the open-label study there was no difference in overall survival between patients treated with recombinant human erythropoietin and controls.
Danish: I det åbne forsøg var der ingen forskel i den samlede overlevelse på patienter behandlet med rekombinant humant erythropoietin og kontrolgruppen.
English: Silapo should be administered either subcutaneously or intravenously.
Danish: Silapo skal gives enten subkutant eller intravenøst.
English: Your doctor may initiate treatment with Silapo if your haemoglobin is 10 g/dl or less.
Danish: Deres læge kan indlede behandling med Silapo, hvis Deres hæmoglobin er 10 g/dl eller mindre.
English: • You may be given iron supplements before and during Silapo treatment to make it more effective.
Danish: • Du kan eventuelt få jerntilskud før og under behandlingen med Silapo, så behandlingen bliver mere effektiv.
English: 150 IU/kg 3x/week or 450 IU/kg once weekly for 4 weeks
Danish: 150 IE/kg 3 gange ugentligt eller 450 IE/kg 1 gang ugentligt i 4 uger
English: Moreover, in patients with a baseline haemoglobin of > 13 g/dl, the possibility that epoetin zeta treatment may be associated with an increased risk of postoperative thrombotic/vascular events cannot be excluded.
Danish: Yderligere kan det for patienter med en koncentration af hæmoglobin på > 13 g/dl fra starten ikke udelukkes, at behandlingen med epoetin zetavil være forbundet med en øget risiko for postoperative trombotiske/vaskulære tilfælde.
English: If you are a patient with chronic renal failure, and particularly if you do not respond properly to Silapo, your doctor will check your dose of Silapo because repeatedly increasing your dose of Silapo if you are not responding to treatment may increase the risk of having a problem of the heart or the blood vessels and could increase risk of myocardial infarction, stroke and death.
Danish: Hvis De har kronisk nyresvigt, og især hvis De ikke reagerer korrekt på Silapo, vil Deres læge kontrollere Deres Silapo-dosis, da De har større risiko for at få problemer med hjertet eller blodkarrene, hvis Deres Silapo-dosis skal øges gentagne gange, fordi De ikke reagerer på behandlingen.
English: The clinical data available suggest that those patients whose initial haemoglobin is very low (< 6.8 g/dl or < 4.25 mmol/l) may require higher maintenance doses than those whose initial haemoglobin is higher > 6.8 g/dl or> 4.25 mmol/l).
Danish: De tilgængelige kliniske data tyder på, at patienter med meget lavt initialt hæmoglobin (< 6,8 g/dl eller < 4,25 mmol/l) kan kræve højere vedligeholdelsesdoser end patienter med initialt hæmoglobin på > 6,8 g/dl eller > 4,25 mmol/l).
English: The starting dose is 450 IU per kilogram bodyweight once a week.
Danish: Startdosis er 450 IE pr. kg. kropsvægt en gang om ugen.
English: Rare: may affect up to 1 in 1 000 people • Symptoms of pure red cell aplasia (PRCA)
Danish: • Symptomer på Pure Red Cell Aplasia (PRCA)
English: Blood pressure should be closely monitored and adequately controlled in all epoetin treatment naïve as well as pre-treated patients before, at initiation of, and during treatment with Silapo.
Danish: Ved starten af og under behandling med Silapo skal blodtrykket nøje overvåges og være under passende kontrol hos alle patienter, der behandles med epoetin, uanset om det er første gang, eller de har været behandlet med stoffet før.
English: • shortened time to tumour progression in patients with advanced head and neck cancer receiving radiation therapy when administered to target a haemoglobin of greater than 14 g/dl (8.7 mmol/l),
Danish: • kortere tid til tumorprogression hos patienter med fremskreden hoved- og halscancer, som får strålebehandling, når stofferne administreres for at tilstræbe et hæmoglobinniveau, som er højere end 14 g/dl (8,7 mmol/l),
English: The rate of increase in haemoglobin should be approximately 1 g/dl (0.62 mmol/l) per month and should not exceed 2 g/dl (1.25 mmol/l) per month to minimise the risk of developing or worsening of hypertension.
Danish: Stigningsraten for hæmoglobin skal være ca. 1 g/dl (0,62 mmol/l) pr. måned, og for at minimere risikoen for øget hypertension bør den ikke overstige 2 g/dl (1,25 mmol/l) for at minimere risikoen for, at patienten udvikler eller oplever en forværring af hypertension.
English: Key baseline characteristics for the <200 mU/ml stratum are shown in the table below.
Danish: De vigtigste baselinekarakteristika for stratummet < 200 mE/ml er anført nedenfor.
English: Silapo should be administered subcutaneously.
Danish: Silapo skal gives subkutant.
English: Remove the protective cap from the injection needle and expel air from the syringe and injection needle by holding the syringe vertically and gently pressing the plunger upwards.
Danish: Tag beskyttelseshætten af sprøjtens nål, og tøm luften ud af sprøjte og nål ved at holde sprøjten lodret og forsigtigt trykke stemplet opad.
English: The initial dose is 150 IU/kg given subcutaneously 3 times per week.
Danish: Initialdosis er 150 IE/kg indgivet subkutant 3 gange om ugen.
English: If haemoglobin level exceeds 12 g/dl (7.5 mmol/l), discontinue therapy until it falls to 12 g/dl (7.5 mmol/l) or lower and then reinstitute Silapo therapy at a dose 25% below the previous dose.
Danish: Hvis hæmoglobinniveauet overstiger 12 g/dl (7,5 mmol/l), ophøres der med terapi, indtil niveauet er faldet til 12 g/dl (7,5 mmol/l)eller derunder, hvorefter Silapo-terapien genoptages med en dosis, som er 25 % under den tidligere dosis.
English: Treatment of symptomatic anaemia in adult and paediatric chronic renal failure patients
Danish: Behandling af symptomatisk anæmi hos voksne og pædiatriske patienter med kronisk nyreinsufficiens
English: Angioneurotic oedema
Danish: Angioneurotisk ødem
English: If you experience headaches, particularly sudden, stabbing migraine-like headaches or feel confused or have fits, tell your doctor immediately.
Danish: Hvis De får hovedpine, især en pludselig dunkende migræneagtig hovedpine, eller føler Dem svimmel eller får krampeanfald, skal De straks fortælle Deres læge om det.
English: Therefore, epoetin zeta should not be used in patients with baseline haemoglobin > 13 g/dl.
Danish: Derfor bør epoetin zetaikke anvendes til patienter med hæmoglobin på > 13g/dl ved baseline.
English: Haemoglobin levels should be measured on a regular basis until a stable level is achieved and periodically thereafter.
Danish: Hæmoglobinniveauerne skal måles jævnligt, indtil niveauet er stabilt, og derefter periodisk.
English: In cases where there is a medical need to shorten the lead time before surgery to less than three weeks, 300 IU/kg should be administered subcutaneously daily for 10 consecutive days prior to surgery, on the day of surgery and for four days immediately thereafter.
Danish: I tilfælde, hvor der er klinisk behov for at indskrænke behandlingstiden før operationen til mindre end tre uger, kan der gives 300 IE/kg Silapo pr. dag i 10 dage før operationen, på selve operationsdagen samt på de 4 første dage umiddelbart efter operationen.