FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Medicines Agency has deferred the obligation to submit the results of studies with rilpivirine in one or more subsets of the paediatric population in the treatment of Human Immunodeficiency Virus (HIV-1) infection (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja rilpivirina u jednoj ili više podskupina pedijatrijske populacije u liječenju infekcije virusom humane imunodeficijencije tipa 1 (HIV-1) (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: - Tell your doctor if you are taking any medicines that may cause a life-threatening irregular heartbeat (Torsade de Pointes).
Croatian: - Recite svom liječniku ako uzimate bilo koji lijek koji može uzrokovati nepravilne otkucaje srca potencijalno opasne za život (Torsade de Pointes).
English: EDURANT works by reducing the amount of HIV in your body.
Croatian: EDURANT djeluje tako što smanjuje količinu virusa HIV-a u Vašem tijelu.
English: EDURANT must be taken with a meal to obtain optimal absorption.
Croatian: EDURANT se mora uzimati uz obrok da bi se dobila optimalna apsorpcija.
English: Further management should be as clinically indicated or as recommended by the national poisons centre, where available.
Croatian: Daljnje zbrinjavanje treba provoditi sukladno kliničkoj indikaciji ili preporukama nacionalnog centra za kontrolu otrovanja, ako on postoji.
English: In the trials, the presence of the mutations V90I and V189I, at baseline, did not affect response.
Croatian: U ispitivanjima prisutnost mutacija V90I i V189I na početku nije utjecala na odgovor.
English: In these patients, phenotypic cross-resistance to other NNRTIs was noted as follows: etravirine 32/42, efavirenz 30/42, and nevirapine 16/42.
Croatian: U ovih bolesnika, zabilježena je slijedeća fenotipska križna rezistencija na druge NNRTI: etravirin 32/42, efavirenz 30/42 i nevirapin 16/42.
English: H2-receptor antagonists should not be taken in a twice a day regimen.
Croatian: Antagonisti H2-receptora ne smiju se uzimati dva puta dnevno.
English: The 36 subjects had a median age of 14.5 years (range: 12 to 17 years), and were 55.6% female, 88.9% Black and 11.1% Asian.
Croatian: Medijan dobi 36 ispitanika bio je 14,5 godina (raspon: 12 do 17 godina), 55,6% ispitanika bilo je ženskog spola, 88,9% crne rase i 11,1% azijatske rase.
English: common decreased appetite increased triglycerides (fasted)
Croatian: često smanjen apetit povišeni trigliceridi (natašte)
English: Pharmacotherapeutic group: Antiviral for systemic use, non-nucleoside reverse transcriptase inhibitors, ATC code: J05AG05.
Croatian: Farmakoterapijska skupina: antivirusni lijekovi za sustavnu primjenu, nenukleozidni inhibitori reverzne transkriptaze, ATK oznaka: J05AG05.
English: EDURANT should be used with caution in this population (see section 4.2).
Croatian: EDURANT treba primjenjivati s oprezom u ovoj populaciji (vidjeti dio 4.2).
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim poremećajima nepodnošenja galaktoze, nedostatkom Lapp laktaze ili malapsorpcijom glukoze i galaktoze ne bi trebali uzimati ovaj lijek.
English: The most frequent serious treatment-related ADRs were reported in 7 (1.0%) patients receiving rilpivirine.
Croatian: Najčešće ozbiljne nuspojave povezane s liječenjem bile su prijavljene u 7 (1,0%) bolesnika koju su primali rilpivirin.
English: One subject discontinued due to an adverse event at week 48, and no additional subjects discontinued due to adverse events in the week 240 analysis.
Croatian: Jedan ispitanik prekinuo je liječenje u 48. tjednu zbog štetnog događaja, a niti jedan dodatni ispitanik nije prekinuo liječenje zbog štetnog događaja tijekom analize u trajanju od 240 tjedana.
English: 6 cells/l in patients receiving efavirenz.
Croatian: 6 stanica/l u bolesnika koji su primali efavirenz.
English: A bottle with child resistant closure containing 30 film-coated tablets.
Croatian: Boca sa sigurnosnim zatvaračem za djecu sadrži 30 filmom obloženih tableta.
English: The effects of EDURANT or other medicines might be influenced if you take EDURANT together with any of the following medicines.
Croatian: Učinci EDURANTA ili drugih lijekova mogu se promijeniti ako uzimate EDURANT zajedno s nekim od niže navedenih lijekova.
English: HIV treatment does not cure HIV infection!
Croatian: Liječenje HIV-a neće izliječiti HIV infekciju!
English: The ADRs are listed by system organ class (SOC) and frequency.
Croatian: Nuspojave su navedene prema klasifikaciji organskih sustava (SOC) i učestalosti.
English: It can be opened by pushing the screw cap down while turning it anti-clockwise.
Croatian: Može se otvoriti tako da zatvarač s navojem pritisnete prema dolje, dok ga okrećete u smjeru suprotnom od kazaljke na satu.
English: e.g. lost to follow-up, non-compliance, withdrew consent.
Croatian: Npr. izgubljeni iz praćenja, nepridržavanje terapije, povlačenje pristanka.
English: There were no new safety findings compared with the known safety profile of rilpivirine in HIV-1 infected adults (see sections 4.2, 4.4 and 5.2).
Croatian: Nije bilo novih sigurnosnih nalaza u usporedbi s poznatim sigurnosnim profilom rilpivirina u odraslih zaraženih HIVom-1 (vidjeti dijelove 4.2, 4.4 i 5.2).
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Croatian: Liječenje treba započeti liječnik s iskustvom u liječenju HIV-infekcije.
English: There were no patients who discontinued treatment due to ADRs.
Croatian: Nije bilo bolesnika koji su prekinuli liječenje zbog nuspojava.
English: The K103N substitution did not result in reduced susceptibility to rilpivirine by itself, but the combination of K103N and L100I resulted in a 7-fold reduced susceptibility to rilpivirine.
Croatian: Supstitucija K103N sama po sebi nije dovela do gubitka osjetljivosti na rilpivirin, ali je kombinacija K103N i L100I dovela do 7-strukog gubitka osjetljivosti na rilpivirin.
English: Rilpivirine + BR N=686
Croatian: Rilpivirin + BR N = 686
English: Do not stop using EDURANT
Croatian: Nemojte prestati uzimati EDURANT
English: EDURANT contains lactose
Croatian: EDURANT sadrži laktozu
English: The pharmacokinetic data demonstrate that total exposure (AUC) to rilpivirine as a part of an antiretroviral regimen was approximately 30% lower during pregnancy compared with postpartum (6-12 weeks).
Croatian: Farmakokinetički podaci pokazuju da je ukupna izloženost (AUC) rilpivirinu kao dijelu antiretrovirusnog režima bila otprilike 30% niža tijekom trudnoće u usporedbi s postpartalnim razdobljem (6-12 tjedana).
English: Fluconazole Itraconazole Posaconazole Voriconazole
Croatian: Flukonazol Itrakonazol Posakonazol Vorikonazol
English: HMG CO-A REDUCTASE INHIBITORS Atorvastatin*
Croatian: INHIBITORI HMG KO-A REDUKTAZE Atorvastatin*
English: Findings in adolescents (12 to less than 18 years of age) in trial TMC278-C213 were generally in line with these data (for details see section 5.1).
Croatian: Nalazi u adolescenata (u dobi od 12 do manje od 18 godina) u ispitivanju TMC278-C213 su općenito bili u skladu s tim podacima (za detalje vidjeti dio 5.1).
English: The exposure to rilpivirine was approximately 40% lower when EDURANT was taken in a fasted condition as compared to a normal caloric meal (533 kcal) or high-fat high-caloric meal (928 kcal).
Croatian: Izloženost rilpivirinu bila je približno 40% niža kad se EDURANT uzimao natašte nego kad se uzimao uz obrok normalne kalorijske vrijednosti (533 kcal) ili visokokalorični obrok bogat mastima (928 kcal).
English: However, it may not be completely excluded that rilpivirine can increase the exposure to other medicines transported by P-glycoprotein that are more sensitive to intestinal P-gp inhibition, e.g. dabigatran etexilate.
Croatian: Međutim, ne može se potpuno isključiti da rilpivirin može povećati izloženost drugim lijekovima koje transportira P-glikoprotein, a koji su osjetljiviji na intestinalnu P-gp inhibiciju, npr. dabigatran eteksilat.
English: Rilpivirine inhibits P-glycoprotein in vitro (IC50 is 9.2 μM).
Croatian: Rilpivirin inhibira P-glikoprotein in vitro (IC50 je 9,2 μM).
English: It is not recommended to co-administer rilpivirine with other NNRTIs.
Croatian: Ne preporučuje se istovremena primjena rilpivirina s drugim NNRTI-jima.
English: Pharmacokinetics of total rilpivirine (mean ± SD, tmax: median [range])
Croatian: Farmakokinetika ukupnog rilpivirina (srednja vrijednost ± SD, tmax: medijan [raspon])
English: Talk to your doctor or pharmacist if you are not sure.
Croatian: Razgovarajte sa svojim liječnikom ili ljekarnikom ako niste sigurni.
English: This analysis included 690 patients in ECHO and 678 patients in THRIVE who had completed 96 weeks of treatment or discontinued earlier.
Croatian: Ova je analiza uključila 690 bolesnika iz ispitivanja ECHO i 678 bolesnika iz ispitivanja THRIVE koji su završili 96 tjedana liječenja ili su ga prekinuli ranije.
English: In the Phase III studies, lower rilpivirine exposure, similar to that seen during pregnancy, has been associated with an increased risk of virological failure, therefore viral load should be monitored closely (see sections 4.6, 5.1 and 5.2).
Croatian: U ispitivanjima faze III, niže izloženosti riplivirinu, slične onima viđenima tijekom trudnoće, bile su povezane s povećanim rizikom od virološkog neuspjeha, stoga je virusno opterećenje potrebno pažljivo nadzirati (vidjeti dijelove 4.6, 5.1 i 5.2).
English: Response (confirmed < 50 HIV-1 RNA copies/ml)
Croatian: S odgovorom (potvrđeno < 50 HIV-1 RNA kopija/ml)
English: In rats, there were no drug-related neoplasms.
Croatian: U štakora nije bilo novotvorina povezanih s lijekom.
English: Common: - abnormal dreams - rash - stomach pain - depression - tiredness - vomiting - drowsiness - decreased appetite - sleep disorders - stomach discomfort - depressed mood - dry mouth
Croatian: Česte: - abnormalni snovi - osip - bol u želucu - depresija - umor - povraćanje - omamljenost - smanjen apetit - poremećaj spavanja - nelagoda u želucu
English: Exposure to rilpivirine was generally lower in HIV-1 infected patients than in healthy subjects.
Croatian: Izloženost rilpivirinu općenito je bila niža u bolesnika zaraženih virusom HIV-1 nego u zdravih ispitanika.
English: Symptoms of overdose may include headache, nausea, dizziness and/or abnormal dreams.
Croatian: Simptomi predoziranja mogu uključivati glavobolju, mučninu, omaglicu i/ili abnormalne snove.
English: No human data on the effect of rilpivirine on fertility are available.
Croatian: Nema dostupnih podataka o učinku rilpivirina na plodnost u ljudi.
English: The observed hepatocellular findings in mice may be rodent-specific.
Croatian: Opaženi hepatocelularni nalazi u miševa mogu biti specifični za glodavce.
English: The most common ADRs (all grades, greater than or equal to 10%) were headache (19.4%), depression (19.4%), somnolence (13.9%), and nausea (11.1%).
Croatian: Najčešće nuspojave (svih stupnjeva, veće ili jednake 10%) bile su glavobolja (19,4%), depresija (19,4%), somnolencija (13,9%), i mučnina (11,1%).
English: Dosing recommendations for paediatric patients less than 12 years of age cannot be made due to insufficient data (see section 4.2).
Croatian: Ne mogu se dati preporuke za doziranje u pedijatrijskih bolesnika mlađih od 12 godina starosti, jer nema dovoljno podataka (vidjeti dio 4.2).
English: * The interaction between rilpivirine and the medicinal product was evaluated in a clinical study.
Croatian: * Interakcija rilpivirina i ovog lijeka ispitana je u kliničkom ispitivanju.
English: There was no impact of body weight on rilpivirine pharmacokinetics in paediatric subjects in trial TMC278-C213 (33 to 93 kg), similar to what was observed in adults.
Croatian: Nije bilo utjecaja tjelesne težine na farmakokinetiku rilpivirina u pedijatrijskih ispitanika u ispitivanju TMC278-C213 (33 do 93 kg), slično kao što je zabilježeno u odraslih.
English: There is limited information available on the potential for a pharmacodynamic interaction between rilpivirine and medicinal products that prolong the QTc interval of the ECG.
Croatian: Dostupni su ograničeni podaci o mogućnosti farmakodinamičke interakcije rilpivirina i lijekova koji produljuju QTc interval na EKG-u.
English: NARCOTIC ANALGESICS Methadone*
Croatian: OPIJATNI ANALGETICI Metadon*
English: Rilpivirine is excreted in the milk of rats.
Croatian: Rilpivirin se izlučuje u mlijeko štakora.
English: If you forget to take EDURANT
Croatian: Ako ste zaboravili uzeti EDURANT
English: Interactions between rilpivirine and co-administered medicinal products are listed in table 1 (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, not applicable as “NA”, confidence interval as “CI”).
Croatian: Interakcije između rilpivirina i istovremeno primijenjenih lijekova navedene su u tablici 1 (povećanje je prikazano kao “↑”, smanjenje kao “↓”, bez promjene kao “↔”, nije primjenjivo kao “NP”, a interval pouzdanosti kao “CI”).
English: Uncommon: - signs or symptoms of inflammation or infection, for example fever, chills, sweats (immune reactivation syndrome)
Croatian: Manje česte: - znakovi ili simptomi upale ili infekcije, na primjer vrućica, zimica, znojenje (sindrom imunološke reaktivacije).
English: ND 3.8%
Croatian: NO 3,8%
English: Metabolism and nutrition disorders very common increased total cholesterol (fasted) increased LDL cholesterol (fasted)
Croatian: Poremećaji metabolizma i prehrane vrlo često povišen ukupni kolesterol (natašte) povišen LDL kolesterol (natašte)
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections and Pneumocystis jiroveci pneumonia.
Croatian: Relevantni primjeri uključuju citomegalovirusni retinitis, generalizirane i/ili fokalne mikobakterijske infekcije i upalu pluća prouzročenu s Pneumocystis jirovecii.
English: When you stop taking rifabutin, take one tablet of EDURANT once a day.
Croatian: Nakon što prestanete uzimati rifabutin, uzimajte jednu tabletu EDURANTA jedanput dnevno.
English: The pharmacokinetics of rilpivirine in paediatric patients less than 12 years of age are under investigation.
Croatian: Farmakokinetika rilpivirina u pedijatrijskih bolesnika mlađih od 12 godina starosti još se ispituje.
English: ND 18.2%
Croatian: NO 18,2%
English: Predicted difference of response rates (95% CI) for the week 48 analysis: 1.6% (-2.2%; 5.3%) and for the week 96 analysis: -0.4% (-4.6%; 3.8%); both p-value < 0.0001 (non-inferiority at 12% margin) from logistic regression model, including stratification factors and study.
Croatian: Predviđena razlika u stopama odgovora (95% CI) za analizu u 48. tjednu: 1,6% (-2,2%; 5,3%) i za analizu u 96. tjednu: -0,4% (-4,6%; 3,8%); p-vrijednost < 0,0001 (neinferiornost uz marginu od 12%) prema modelu logističke regresije, uključujući stratifikacijske čimbenike i ispitivanje.
English: The decrease in unbound (ie, active) rilpivirine pharmacokinetic parameters during pregnancy compared to postpartum was less pronounced than for total rilpivirine.
Croatian: Smanjenje farmakokinetičkih parametara nevezanog (tj. aktivnog) rilpivirina tijekom trudnoće u usporedbi s postpartalnim razdobljem bilo je manje izraženo nego za ukupni rilpivirin.
English: Rilpivirine does not inhibit the human cellular DNA polymerases α, β and γ.
Croatian: Rilpivirin ne inhibira ljudske stanične DNK polimeraze α, β i γ.
English: Treatment with rilpivirine resulted in an early small increase of mean serum creatinine levels which remained stable over time and is not considered clinically relevant (see section 4.8).
Croatian: Liječenje rilpivirinom rezultiralo je ranim blagim porastom srednje vrijednosti razina kreatinina u serumu koja je ostala stabilna tijekom vremena te se nije smatrala klinički značajnom (vidjeti dio 4.8).
English: Population pharmacokinetic analysis in HIV infected patients showed that rilpivirine pharmacokinetics are not different across the age range (18 to 78 years) evaluated, with only 3 subjects aged 65 years or older.
Croatian: Populacijska farmakokinetička analiza u bolesnika zaraženih HIV-om pokazala je da nema razlika u farmakokinetici rilpivirina u procijenjenoj dobnoj skupini (18 do 78 godina), s time da je samo troje ispitanika bilo u dobi od 65 ili više godina.
English: Rilpivirine in combination with a background regimen was evaluated in a clinical trial of 19 pregnant women during the second and third trimesters, and postpartum.
Croatian: Rilpivirin u kombinaciji s pratećim liječenjem bio je procijenjen u kliničkom ispitivanju s 19 trudnih žena tijekom drugog i trećeg tromjesečja, te postpartalno.
English: In a clinical study, rilpivirine did not significantly affect the pharmacokinetics of digoxin.
Croatian: U kliničkom ispitivanju, rilpivirin nije značajno utjecao na farmakokinetiku digoksina.
English: Some patients may experience tiredness, dizziness or drowsiness during treatment with EDURANT.
Croatian: Neki bolesnici mogu osjetiti umor, omaglicu ili pospanost tijekom liječenja EDURANTOM.
English: Renal elimination of rilpivirine is negligible.
Croatian: Bubrežna eliminacija rilpivirina je zanemariva.
English: Didanosine should be administered on an empty stomach at least two hours before or at least four hours after EDURANT (which must be taken with a meal).
Croatian: Didanozin treba primijeniti na prazan želudac najmanje dva sata prije ili najmanje 4 sata nakon EDURANTA (koji se mora uzeti uz obrok).
English: EDURANT must be taken orally, once daily with a meal (see section 5.2).
Croatian: EDURANT se mora uzimati peroralno, jedanput dnevno, uz obrok (vidjeti dio 5.2).
English: Tenofovir disoproxil fumarate*
Croatian: Tenofovir dizoproksil fumarat*
English: However, it may not be excluded that the pharmacologically active, unbound, rilpivirine exposure is significantly increased in moderate hepatic impairment.
Croatian: Međutim, ne može se isključiti mogućnost da je izloženost farmakološki aktivnom nevezanom rilpivirinu značajno povećana kod umjerenog oštećenja jetre.
English: EDURANT has mainly been studied in patients with normal renal function.
Croatian: EDURANT je ispitivan uglavnom u bolesnika s normalnom funkcijom bubrega.
English: Medicinal products that affect rilpivirine exposure
Croatian: Lijekovi koji utječu na izloženost rilpivirinu
English: Talk to your doctor about an alternative regimen.
Croatian: Razgovarajte s liječnikom o alternativnom načinu uzimanja lijeka.
English: The median baseline plasma HIV-1 RNA was 4.8 log10 copies per ml, and the median baseline CD4+ cell count was 414 × 10
Croatian: Medijan početne vrijednosti HIV-1 RNA u plazmi bio je 4,8 log10 kopija po ml, a medijan početnog broja CD4+ stanica bio je 414 × 10
English: Very common: - headache - nausea - difficulty falling asleep (insomnia) - dizziness - changes in one of your routine liver tests (transaminase) - increase in cholesterol and/or pancreatic amylase in your blood
Croatian: Vrlo česte: - glavobolja - mučnina - poteškoće s uspavljivanjem (nesanica) - omaglica - promjena jednog nalaza na rutinskim jetrenim pretragama (transaminaze) - povišenje kolesterola i/ili amilaze gušterače u krvi.
English: # to emtricitabine/lamivudine % (n/N)
Croatian: # na emtricitabin/lamivudin % (n/N)
English: No dose adjustment is required.
Croatian: Prilagodba doze nije potrebna.
English: Lower exposures of rilpivirine were observed when rilpivirine 25 mg once daily was taken during pregnancy.
Croatian: Niže izloženosti rilpivirinu bile su uočene kada se uzimalo 25 mg rilpivirina jedanput na dan tijekom trudnoće.
English: As with other antiretroviral medicinal products, resistance testing should guide the use of rilpivirine (see section 5.1).
Croatian: Kao i kod drugih antiretrovirusnih lijekova, u primjeni rilpivirina treba se voditi testom rezistencije (vidjeti dio 5.1).
English: The EDURANT tablet must be taken with a meal.
Croatian: Tableta EDURANTA mora se uzeti uz obrok.
English: If you notice within 12 hours of the time you usually take EDURANT, you must take the tablet as soon as possible.
Croatian: Ako to primijetite unutar 12 sati od vremena kad obično uzimate EDURANT, morate što prije uzeti tabletu.
English: These resistance-associated mutations were derived from in vivo data involving treatment-naïve subjects only and therefore cannot be used to predict the activity of rilpivirine in subjects who have virologically failed an antiretroviral-containing regimen.
Croatian: Ove, s rezistencijom povezane mutacije izvedene su iz in vivo podataka samo onih ispitanika koji prethodno nisu bili liječeni, stoga se ne mogu koristiti za predviđanje djelovanja rilpivirina u ispitanika u kojih je liječenje antiretrovirusnim lijekovima bilo virološki neuspješno.
English: 75 ml high density polyethylene (HDPE) bottle with a polypropylene (PP) child resistant closure and induction seal liner.
Croatian: Boca od 75 ml od polietilena visoke gustoće (HDPE) s polipropilenskim (PP) sigurnosnim zatvaračem za djecu i zaštitnom folijom.
English: EU/1/11/736/001
Croatian: BROJ ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/11/736/001
English: EDURANT should be used with caution in this population.
Croatian: U ovoj populaciji EDURANT treba primjenjivati s oprezom.
English: 6 cells/l in patients receiving rilpivirine 25 mg and 160 × 10
Croatian: 6 stanica/l u bolesnika koji su primali rilpivirin od 25 mg i 160 × 10
English: In mice, rilpivirine was positive for hepatocellular neoplasms in both males and females.
Croatian: Kod miševa, rilpivirin je bio pozitivan na hepatocelularne neoplazme i u ženki i mužjaka.
English: (induction of CYP3A due to high rilpivirine dose in the study)
Croatian: (indukcija CYP3A zbog visoke doze rilpivirina u ispitivanju)
English: However, fatigue, dizziness and somnolence have been reported in some patients taking EDURANT and should be considered when assessing a patient's ability to drive or operate machinery.
Croatian: Međutim, u nekih bolesnika koji su uzimali EDURANT zabilježeni su umor, omaglica i somnolencija, što treba uzeti u obzir kad se procjenjuje sposobnost bolesnika da upravlja vozilima i radi sa strojevima.
English: There is limited information regarding the use of EDURANT in patients with mild or moderate hepatic impairment (Child-Pugh score A or B).
Croatian: Dostupni su ograničeni podaci o primjeni EDURANTA u bolesnika s blagim ili umjerenim oštećenjem jetre (Child-Pugh stadij A ili B).
English: ND 0.1%
Croatian: NO 0,1%
English: You must take EDURANT together with other HIV medicines.
Croatian: EDURANT morate uzimati zajedno s drugim lijekovima protiv HIV-a.
English: Do not use this medicine after the expiry date which is stated on the carton and on the bottle after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i boci iza oznake “Rok valjanosti”.
English: In a panel of 67 HIV-1 recombinant laboratory strains with one resistance-associated mutation at RT positions associated with NNRTI resistance, including the most commonly found K103N and Y181C, rilpivirine showed antiviral activity against 64 (96%) of these strains.
Croatian: U panelu od 67 rekombinantnih laboratorijskih sojeva virusa HIV-1 s jednom mutacijom povezanom s rezistencijom na položajima na reverznoj transkriptazi (RT) povezanima s rezistencijom na NNRTI, uključujući najčešće prisutne K103N i Y181C, rilpivirin je pokazao antivirusnu aktivnost na 64 (96%) ovih sojeva.
English: Although rilpivirine demonstrated limited in vitro activity against HIV-2 with EC50 values ranging from 2,510 to 10,830 nM (920 to 3,970 ng/ml), treatment of HIV-2 infection with rilpivirine is not recommended in the absence of clinical data.
Croatian: Premda je rilpivirin pokazao ograničeno in vitro djelovanje na virus HIV-2 uz vrijednosti EC50 u rasponu od 2 510 do 10 830 nM (920 do 3 970 ng/ml), ne preporučuje se liječenje HIV-2 infekcije rilpivirinom obzirom da nema kliničkih podataka.