FrancophonIA/ELRC3.0 huggingface dataset:
English: The patients whose sera tested positive for binding antibodies were further evaluated for neutralising antibodies and none of the patients tested positive for neutralising antibodies.
Croatian: U bolesnika pozitivnih na vezna protutijela u serumu dodatno se provjeravala prisutnost neutralizirajućih protutijela i nitko od bolesnika nije bio pozitivan na njih.
English: • One Repatha pre-filled syringe in its tray.
Croatian: • Jednu Repatha napunjenu štrcaljku u njezinom podlošku.
English: Press down firmly
Croatian: Čvrsto pritisnite prema dolje
English: Following a single 420 mg Repatha intravenous dose, the mean (SD) steady-state volume of distribution was estimated to be 3.3 (0.5) L, suggesting evolocumab has limited tissue distribution.
Croatian: Nakon primjene jednokratne intravenske doze lijeka Repatha od 420 mg, srednja vrijednost (SD) volumena distribucije u stanju dinamičke ravnoteže procjenjuje se na 3,3 (0,5) l, ukazujući na ograničenu distribuciju evolokumaba u tkivima.
English: • You may feel a needle pinch.
Croatian: • Možete osjetiti ubod igle.
English: It is not known whether Repatha is found in breast milk.
Croatian: Nije poznato izlučuje li se Repatha u majčino mlijeko.
English: Up to 99% of patients treated with either dose of Repatha achieved an LDL-C of < 2.6 mmol/L and up to 95% achieved an LDL-C < 1.8 mmol/L at the mean of weeks 10 and 12.
Croatian: Do 99% bolesnika liječenih bilo kojom dozom lijeka Repatha postiglo je vrijednost LDL-C-a od <2,6 mmol/L, a do 95% njih postiglo je vrijednost LDL-C-a < 1,8 mmol/L pri srednjoj vrijednosti u 10. i 12. tjednu.
English: • Slowly and gently push the plunger rod up to get the air out of the pre-filled syringe.
Croatian: • polako i lagano potisnite klip prema gore kako bi se uklonio zrak iz napunjene štrcaljke.
English: It is important to keep the skin pinched while injecting.
Croatian: Važno je držati nabor kože za vrijeme injiciranja.
English: Part of the automated mini-doser and cartridge may be broken even if you cannot see the break.
Croatian: Dio automatiziranog mini-dozatora i uloška može biti oštećen iako možda ne vidite oštećenje.
English: Avoid injecting into areas with wrinkles, skin folds, scars, stretch marks, moles and excessive hair.
Croatian: Izbjegavajte injiciranje u područja s borama, naborima kože, ožiljcima, strijama, madežima ili pretjeranom dlakavošću.
English: (HMD) (combined rosuvastatin, simvastatin, & atorvastatin groups)
Croatian: (HMD) (skupine koje su primale kombinaciju s rosuvastatinom, simvastatinom i atorvastatinom)
English: A Remove the automated mini-doser and cartridge carton from the refrigerator.
Croatian: Izvadite kutiju automatiziranog mini-dozatora i uloška iz hladnjaka.
English: • Keep the automated mini-doser and cartridge in the original carton in order to protect from light or physical damage.
Croatian: • Držite automatizirani mini-dozator i uložak u originalnoj kutiji kako bi bili zaštićeni od svjetlosti i mehaničkih oštećenja.
English: The administration device is designed for use only with the provided 3.5 mL pre-filled cartridge assembly.
Croatian: Uređaj za primjenu namijenjen je uporabi samo s priloženim napunjenim uloškom od 3,5 ml.
English: Clean the injection site with an alcohol wipe.
Croatian: Očistite područje injiciranja alkoholnom maramicom.
English: DO NOT: Pick up or pull the pre-filled syringe by the plunger rod or grey needle cap.
Croatian: NEMOJTE: primati ili potezati napunjenu štrcaljku za klip ili sivi zatvarač igle.
English: • an adult with a high cholesterol level in your blood (primary hypercholesterolaemia [heterozygous familial and non-familial] or mixed dyslipidaemia).
Croatian: • ste odrasla osoba s visokom razinom kolesterola u krvi (primarna hiperkolesterolemija [heterozigotna obiteljska i stečena] ili miješana dislipidemija).
English: Adhesive paper
Croatian: Prianjajući papir
English: Population pharmacokinetic analysis indicated no appreciable differences in evolocumab serum concentrations in hypercholesterolaemic patients (nonfamilial hypercholesterolaemia or familial hypercholesterolaemia) taking concomitant statins.
Croatian: Populacijska farmakokinetička analiza nije pokazala nikakve mjerljive razlike u serumskim koncentracijama evolokumaba u bolesnika s hiperkolesterolemijom (stečenom ili obiteljskom) koji istovremeno uzimaju statine.
English: There is limited experience with Repatha in patients with severe renal impairment (see section 4.4).
Croatian: Postoje ograničeni podaci za lijek Repatha u bolesnika s teškim oštećenjem bubrega (vidjeti dio 4.4).
English: • Do not try to reposition the loaded automated mini-doser after it has been placed onto your skin.
Croatian: • Nemojte pokušavati premjestiti napunjeni automatizirani mini-dozator nakon što ste ga učvrstili na kožu.
English: An approximate two to three-fold accumulation was observed in trough serum concentrations (Cmin (SD) 7.21 (6.6)) following 140 mg doses every 2 weeks or following 420 mg doses administered monthly (Cmin (SD) 11.2 (10.8)), and serum trough concentrations approached steady-state by 12 weeks of dosing.
Croatian: Uočena je približno dvostruka do trostruka akumulacija u najnižim koncentracijama lijeka u serumu (Cmin (SD) 7,21 (6,6)) nakon doza od 140 mg svaka 2 tjedna ili nakon doza od 420 mg primijenjenih mjesečno (Cmin (SD) 11,2 (10,8)), a te su se najniže koncentracije lijeka u serumu približile stanju dinamičke ravnoteže do 12. tjedna doziranja.
English: Multipack: 6 (3 packs of 2) single use SureClick pre-filled pens.
Croatian: Višestruko pakiranje: 6 (3 pakiranja sa po 2) SureClick napunjenih brizgalica za jednokratnu primjenu.
English: Step 4: Finish A Immediately place the used syringe in a sharps disposal container.
Croatian: Korak 4: Završni korak A Odmah odložite iskorištenu štrcaljku u spremnik za odlaganje oštrog otpada.
English: Following a single 420 mg intravenous dose, the mean (SD) systemic clearance was estimated to be 12 (2) mL/hr.
Croatian: Nakon primjene jednokratne intravenske doze od 420 mg, srednja vrijednost (SD) sistemskog klirensa procijenjena je na 12 (2) ml/h.
English: Use a new Repatha pre-filled syringe.
Croatian: Primijenite novu Repatha napunjenu štrcaljku.
English: OLE Week 216
Croatian: OLE 216.tjedan
English: Animal studies did not show any effects on fertility endpoints at area under the concentration time curve (AUC) exposure levels much higher than in patients receiving evolocumab at 420 mg once monthly (see section 5.3).
Croatian: Ispitivanja na životinjama nisu pokazala nikakve učinke na ishode plodnosti pri razinama izloženosti (temeljem površine ispod krivulje koncentracija vrijeme, AUC) koje su bile mnogo više nego u bolesnika koji su primali evolokumab u dozi od 420 mg jedanput mjesečno (vidjeti dio 5.3).
English: • The status light changes to solid green.
Croatian: • Se svjetlost na lampici promijeni u stalnu zelenu.
English: • The name Repatha appears on the pre-filled syringe label.
Croatian: • da se ime Repatha nalazi na naljepnici na napunjenoj štrcaljki.
English: Part of the syringe may be broken even if you cannot see the break.
Croatian: Dio štrcaljke može biti oštećen iako možda ne vidite oštećenje.
English: D Choose your automated mini-doser placement.
Croatian: D Odaberite gdje ćete postaviti automatizirani mini-dozator.
English: Treatment effects were maintained as demonstrated by reduction in LDL-C from week 12 to week 104 in the open-label extension.
Croatian: Učinci liječenja su bili održani, kao što je pokazano smanjenjem LDL-C-a od 12. do 104. tjedna u otvorenom produžetku ispitivanja.
English: • Do not freeze or use the Repatha pre-filled pen if it has been frozen.
Croatian: • Nemojte zamrzavati ili koristiti Repatha napunjenu brizgalicu koja je bila zamrznuta.
English: Before you use the automated mini-doser and cartridge for use with Repatha, read this important information:
Croatian: Prije primjene automatiziranog mini-dozatora i uloška za primjenu s lijekom Repatha, pročitajte ove važne informacije:
English: The safety and effectiveness of Repatha in paediatric patients with primary hypercholesterolaemia and mixed dyslipidaemia has not been established.
Croatian: Sigurnost i učinkovitost lijeka Repatha u pedijatrijskih bolesnika s primarnom hiperkolesterolemijom i miješanom dislipidemijom nisu ustanovljene.
English: • Put the used automated mini-doser in sharps disposal container right away after use.
Croatian: • Bacite iskorišteni automatizirani mini-dozator u spremnik za odlaganje oštrog otpada odmah nakon primjene.
English: Important: Always keep the sharps disposal container out of the sight and reach of children.
Croatian: Važno: Uvijek čuvajte spremnik za odlaganje oštrog otpada izvan pogleda i dohvata djece.
English: Injection sites should be rotated and injections should not be given into areas where the skin is tender, bruised, red, or hard.
Croatian: Mjesta primjene treba izmijenjivati, a injekcije se ne smiju primjenjivati na područjima gdje je koža osjetljiva, s modricama, crvena, ili tvrda.
English: An approximately 20% increase in the clearance of evolocumab was observed in patients co-administered statins.
Croatian: Povećanje klirensa evolokumaba za oko 20% uočeno je u bolesnika koji su istovremeno primjenjivali statine.
English: Window Medicine
Croatian: Prozorčić Lijek
English: Use the Repatha pre-filled syringe if it has been dropped onto a hard surface.
Croatian: koristiti Repatha napunjenu štrcaljku ako je pala na čvrstu površinu.
English: There is limited experience with Repatha in paediatric patients.
Croatian: Iskustvo s primjenom lijeka Repatha u pedijatrijskih bolesnika je ograničeno.
English: • Make sure you see a green, flashing status light.
Croatian: • Provjerite da lampica treperi zelenom svjetlošću.
English: What Repatha is used for
Croatian: Za što se Repatha koristi
English: Step 3: Inject A Hold the PINCH.
Croatian: Korak 3: Injiciranje A Držite NABOR kože.
English: Repatha is for subcutaneous injection into the abdomen, thigh or upper arm region.
Croatian: Repatha se primjenjuje supkutanom injekcijom u područje abdomena, bedra ili nadlaktice.
English: The absolute bioavailability after SC dosing was determined to be 72% from pharmacokinetic models.
Croatian: Farmakokinetičkim modelima određeno je da apsolutna bioraspoloživost nakon s.c. doziranja iznosi 72%.
English: No difference in safety was observed between adolescent and adult patients with homozygous familial hypercholesterolaemia.
Croatian: Nije opažena razlika u sigurnosti primjene između adolescenata i odraslih bolesnika s homozigotnom obiteljskom hiperkolesterolemijom.
English: Body weight was a significant covariate in population PK analysis impacting evolocumab trough concentrations, however there was no impact on LDL-C reduction.
Croatian: Tjelesna težina je bila značajna kovarijanta u populacijskoj farmakokinetičkoj analizi, s utjecajem na najniže koncentracije evolokumaba, međutim bez utjecaja na smanjenje LDL-C-a.
English: In TAUSSIG, long-term use of Repatha demonstrated a sustained treatment effect as evidenced by reduction of LDL-C of approximately 20% to 30% in patients with homozygous familial hypercholesterolaemia not on apheresis and approximately 10% to 30% in patients with homozygous familial hypercholesterolaemia on apheresis (table 7).
Croatian: U ispitivanju TAUSSIG, dugoročna primjena lijeka Repatha pokazala je održani učinak liječenja, kao što je dokazano smanjenjem vrijednosti LDL-C-a od oko 20% do 30% u bolesnika s homozigotnom obiteljskom hiperkolesterolemijom koji nisu bili na aferezi, te oko 10% do 30% u bolesnika s homozigotnom obiteljskom hiperkolesterolemijom na aferezi (Tablica 7).
English: Sterilised using ethylene oxide
Croatian: Sterilizirano primjenom etilenoksida
English: • New pre-filled pen.
Croatian: • Novu napunjenu brizgalicu.
English: • Do not try to warm the cartridge by using a heat source such as hot water or a microwave.
Croatian: • Nemojte pokušavati ugrijati uložak korištenjem izvora topline kao što su vruća voda ili mikrovalna pećnica.
English: Do not try to warm the pre-filled pen by using a heat source such as hot water or microwave.
Croatian: Nemojte pokušavati ugrijati napunjenu brizgalicu korištenjem izvora topline kao što su vruća voda ili mikrovalna pećnica.
English: No overall differences in safety or efficacy were observed between adolescent and adult patients with homozygous familial hypercholesterolaemia.
Croatian: Nema ukupne razlike u sigurnosti ili djelotvornosti uočene između adolescenata i odraslih bolesnika s homozigotnom obiteljskom hiperkolesterolemijom.
English: • Joint pain (arthralgia)
Croatian: • Bol u zglobovima (artralgija)
English: • for adults with established atherosclerotic cardiovascular disease (a history of heart attack, stroke or blood vessel problems) the dose is either 140 mg every two weeks or 420 mg once monthly.
Croatian: • za liječenje odraslih s ustanovljenom aterosklerotskom kardiovaskularnom bolesti (srčani udar, moždani udar ili problemi s krvnim žilama u povijesti bolesti), doza iznosi ili 140 mg svaka dva tjedna ili 420 mg jedanput mjesečno.
English: No adverse effects were observed in animal studies at exposures up to 300-fold higher than those in patients treated with Repatha at 420 mg once monthly.
Croatian: Nisu zamijećene nikakve nuspojave u ispitivanjima na životinjama pri izloženosti do 300 puta većoj od one u bolesnika liječenih lijekom Repatha u dozi od 420 mg jedanput mjesečno.
English: • The automated mini-doser and cartridge must be kept in the refrigerator (2ºC - 8ºC).
Croatian: • Automatizirani mini-dozator i uložak moraju se čuvati u hladnjaku (2ºC - 8ºC).
English: Evolocumab was not carcinogenic in hamsters at exposures much higher than patients receiving evolocumab at 420 mg once monthly.
Croatian: Evolokumab nije bio kancerogen u hrčaka pri mnogo većoj izloženosti u odnosu na bolesnike koji su primali evolokumab u dozi od 420 mg jedanput mjesečno.
English: If your doctor prescribes a dose of 420 mg you must use three pre-filled syringes because each pre-filled syringe only contains 140 mg of medicine.
Croatian: Ako Vam je liječnik propisao dozu od 420 mg, trebate primijeniti tri napunjene štrcaljke jer pojedinačna štrcaljka sadrži samo 140 mg lijeka.
English: • If removed from the refrigerator, the automated mini-doser and cartridge can be kept at room temperature (20ºC - 25ºC) in the original carton and must be used within 1 month.
Croatian: • Ako se izvade iz hladnjaka, automatizirani mini-dozator i uložak mogu se čuvati na sobnoj temperaturi (20°C - 25°C) u originalnoj kutiji i moraju se upotrijebiti unutar 1 mjeseca.
English: Wait at least 30 minutes for the pre-filled syringe in the carton to naturally reach room temperature before injecting.
Croatian: Pričekajte barem 30 minuta kako bi napunjena štrcaljka u kutiji dosegnula sobnu temperaturu prirodnim putem prije injiciranja.
English: Keep dry
Croatian: Držati na suhom
English: the medicine is discoloured or contains large lumps, flakes or coloured particles.
Croatian: lijek je promijenio boju, ili sadrži velike grudice, pahuljaste ili obojane čestice.
English: Repatha is a solution which is clear to opalescent, colourless to yellowish, and practically free from particles.
Croatian: Repatha je bistra do opalescentna, bezbojna do žućkasta otopina i praktički bez čestica.
English: • Do not use the automated mini-doser and cartridge if either have been dropped onto a hard surface.
Croatian: • Nemojte koristiti automatizirani mini-dozator i uložak ako je bilo koji od njih pao na čvrstu površinu.
English: • Adult supervision is recommended for 12 and 13 year olds while using the automated mini-doser and cartridge.
Croatian: • Preporučuje se da 12- i 13-godišnjake prilikom korištenja automatiziranog mini-dozatora nadzire odrasla osoba.
English: The safety and efficacy of Repatha in children aged less than 12 years has not been established in the indication for homozygous familial hypercholesterolaemia.
Croatian: Sigurnost i djelotvornost lijeka Repatha u djece mlađe od 12 godina nisu još ustanovljene u indikaciji za homozigotnu obiteljsku hiperkolesterolemiju.
English: Key: Q2W = once every 2 weeks, QM = once monthly, HMD = Primary hypercholesterolaemia and mixed dyslipidaemia; HeFH = Heterozygous familial hypercholesterolaemia; a p value < 0.05 when compared with placebo.
Croatian: Legenda: Q2W = jedanput svaka 2 tjedna, QM = jedanput mjesečno, HMD = Primarna hiperkolesterolemija i miješana dislipidemija; HeFH = Heterozigotna obiteljska hiperkolesterolemija; a p vrijednost < 0,05 pri usporedbi s placebom.
English: You should keep on this cholesterol lowering diet while taking Repatha.
Croatian: Trebate nastaviti s tom dijetom za snižavanje kolesterola za vrijeme primjene lijeka Repatha.
English: Homozygous familial hypercholesterolaemia in adults and adolescents aged 12 years and over The initial recommended dose is 420 mg once monthly.
Croatian: Homozigotna obiteljska hiperkolesterolemija u odraslih i adolescenata u dobi od 12 i više godina Preporučena početna doza je 420 mg jedanput mjesečno.
English: TC/ HDL-C Ratio
Croatian: TC/ HDL-C omjer
English: The most frequent injection site reactions were injection site bruising, erythema, haemorrhage, injection site pain, and swelling.
Croatian: Najčešće reakcije na mjestu primjene su modrice na mjestu primjene, eritem, krvarenje, bol i oticanje na mjestu primjene.
English: A 3.5 mL solution in a single use cartridge made from cyclic olefin polymer with elastomer septum and piston as product-contact materials, and a resin cap.
Croatian: 3,5 ml otopine u ulošku za jednokratnu primjenu, načinjenom od polimera cikličkog olefina s elastomernom pregradom i klipom kao materijalima u dodiru s lijekom, te čepom od smole.
English: Atherosclerotic regression was observed in 64.3% (95% CI 59.6, 68.7) and 47.3% (95% CI 42.6, 52.0) of patients who received Repatha or placebo respectively when measured by PAV.
Croatian: Regresija aterosklerotske bolesti opažena je u 64,3% (95% CI 59,6, 68,7) i 47,3% (95% CI 42,6, 52,0) bolesnika koji su primali lijek Repatha odnosno placebo pri mjerenju PAV-a.
English: TC/ HDLC ratio
Croatian: TC/ HDLC omjer
English: Administration of single subcutaneous dose of 140 mg resulted in a Cmax mean (SD) of 13.0 (10.4) μg/mL and AUClast mean (SD) of 96.5 (78.7) day•μg/mL.
Croatian: Primjena jednokratne supkutane doze od 140 mg rezultirala je srednjom vrijednosti Cmax (SD) od 13,0 (10,4) µg/ml i srednjom vrijednosti AUClast (SD) od 96,5 (78,7) dan•μg/ml.
English: In cynomolgus monkeys at exposures much higher than patients receiving 420 mg evolocumab once monthly, no effects on embryo-foetal or postnatal development (up to 6 months of age) were observed.
Croatian: U makaki majmuna pri mnogo većoj izloženosti u odnosu na bolesnike koji su primali evolokumab u dozi od 420 mg jedanput mjesečno, nisu uočeni učinci na embrio-fetalni ili postnatalni razvoj (do 6 mjeseci starosti).
English: When measured by TAV, atherosclerotic regression was observed in 61.5% (95% CI 56.7, 66.0) and 48.9% (95% CI 44.2, 53.7) of patients who received Repatha or placebo respectively.
Croatian: Pri mjerenju TAV-a, regresija aterosklerotske bolesti opažena je u 61,5% (95% CI 56,7, 66,0) i 48,9% (95% CI 44,2, 53,7) bolesnika koji su primali lijek Repatha odnosno placebo.
English: • Belly, except for a 2-inch (5 centimetre) area around your belly button
Croatian: • Trbuh, osim u području od 5 centimetara oko pupka
English: Severe FH (non-HoFH) (N = 194) Key: OLE = open-label extension, N (n) = Number of evaluable patients (N) and patients with observed LDL values at specific scheduled visit (n) in the severe familial hypercholesterolaemia (non-HoFH) final analysis set.
Croatian: Teška obiteljska hiperkolesterolemija (bez homozigotne obiteljske hiperkolesterolemije) (N = 194) Legenda: OLE = otvoreni produžetak ispitivanja, N (n) = broj procjenjivih bolesnika (N) i bolesnika s uočenim LDL vrijednostima mjerenim pri specifičnim zakazanim posjetima (n) u setu konačne analize za tešku obiteljsku hiperkolesterolemiju (bez homozigotne obiteljske hiperkolesterolemije).
English: OLE Week 48
Croatian: OLE 48. tjedan
English: OLE Week 192
Croatian: OLE 192. tjedan
English: ApoB/ ApoA1 ratio
Croatian: ApoB/ ApoA1 omjer
English: Administration of single subcutaneous dose 420 mg resulted in a Cmax mean (SD) of 46.0 (17.2) μg/mL and AUClast mean (SD) of 842 (333) day•μg/mL.
Croatian: Primjena jednokratne supkutane doze od 420 mg rezultirala je srednjom vrijednosti Cmax (SD) od 46,0 (17,2) µg/ml i srednjom vrijednosti AUClast (SD) od 842 (333) dan•μg/ml.
English: Repatha should be used with caution in patients with severe hepatic impairment.
Croatian: Lijek Repatha treba primjenjivati s oprezom u bolesnika s teškim oštećenjem jetre.
English: If your doctor prescribes a dose of 420 mg you must use three pre-filled pens because each pre-filled pen only contains 140 mg of medicine.
Croatian: Ako Vam je liječnik propisao dozu od 420 mg, trebate primijeniti tri napunjene brizgalice jer pojedinačna brizgalica sadrži samo 140 mg lijeka.
English: Back view
Croatian: Stražnja strana
English: • The used automated mini-doser will beep when removed from your skin.
Croatian: • Iskorišteni automatizirani mini-dozator će proizvesti zvučni signal kada ga uklonite s kože.
English: Refer to Instructions for Use
Croatian: 15. UPUTE ZA UPORABU
English: Long-term efficacy in primary hypercholesterolaemia and mixed dyslipidaemia
Croatian: Dugoročna djelotvornost kod primarne hiperkolesterolemije i miješane dislipidemije
English: There are limited data available on the use of Repatha in the paediatric population.
Croatian: Dostupni podaci o primjeni lijeka Repatha u pedijatrijskoj populaciji su ograničeni.
English: It is unknown whether evolocumab is excreted in human milk.
Croatian: Nije poznato izlučuje li se evolokumab u majčino mlijeko.
English: DO NOT use the pre-filled syringe if: any part of the pre-filled syringe appears cracked or broken.
Croatian: NEMOJTE koristiti napunjenu štrcaljku ako: bilo koji dio napunjene štrcaljke izgleda napuknuto ili oštećeno.
English: Each pack contains one single use cartridge co-packed with a single use automated mini-doser.
Croatian: Svako pakiranje sadrži jedan uložak za jednokratnu primjenu i automatizirani mini-dozator za jednokratnu primjenu.
English: Leave the automated mini-doser and cartridge in the clear tray until you are ready to inject.
Croatian: Ostavite automatizirani mini-dozator i uložak u prozirnom podlošku sve dok niste spremni za injiciranje.
English: In hamsters and cynomolgus monkeys at exposures much higher than patients receiving 420 mg evolocumab once monthly, no effect on male or female fertility was observed.
Croatian: U hrčaka i makaki majmuna, pri mnogo većoj izloženosti u odnosu na bolesnike koji su primali evolokumab u dozi od 420 mg jedanput mjesečno, nije uočen učinak na mušku ili žensku plodnost.
English: • Flu (high temperature, sore throat, runny nose, cough and chills)
Croatian: • Gripa (visoka temperatura, grlobolja, curenje iz nosa, kašalj i zimica)
English: Repatha 420 mg once monthly, as an adjunct to other lipid-lowering therapies (e.g., statins, bile-acid sequestrants), significantly reduced LDL-C and ApoB at week 12 compared with placebo (p < 0.001) (table 6).
Croatian: Repatha u dozi od 420 mg jedanput mjesečno, kao dodatak drugim terapijama za snižavanje lipida (npr. statini, sekvestranti žučne kiseline), je značajno smanjila vrijednosti LDL-C-a i ApoB-a u 12. tjednu u usporedbi s placebom (p < 0,001) (Tablica 6).
English: OLE Week 12
Croatian: OLE 12. tjedan
English: • Do not touch the start button until you have placed the loaded automated mini-doser on your skin.
Croatian: • Nemojte dodirivati dugme za injiciranje sve dok niste postavili napunjeni automatizirani mini-dozator na kožu.
English: Keep the stretch (belly area method only).
Croatian: Držite kožu rastegnutom (samo za područje trbuha).
English: Altitude range is -300 metres to 3,500 metres (-984 feet to 11,483 feet).
Croatian: Raspon nadmorske visine je od -300 metara do 3500 metara.