FrancophonIA/ELRC3.0 huggingface dataset:
English: Tell your doctor straight away if you get any of these side effects as you may need urgent medical treatment: - Sudden swelling of your lips, face, throat or tongue, a rash, swallowing or breathing problems.
Slovenian: Svojemu zdravniku nemudoma povejte, če se pri vas pri vas pojavi kateri od omenjenih neželenih učinkov, ker boste lahko potrebovali nujno medicinsko zdravljenje: - nenadno otekanje ustnic, obraza, žrela ali jezika, izpuščaj in težave s požiranjem ali dihanjem.
English: Storage of reconstituted solutions
Slovenian: Shranjevanje rekonstituiranih raztopin
English: Doripenem-M-1 had a slow elimination in the patient group and the half-life (and AUC) has not been satisfactorily determined.
Slovenian: Doripenem-M-1 se je slabo izločal v tej skupini bolnikov, razpolovni čas (in AUC) pa ni bil zadovoljivo določen.
English: Pharmacotherapeutic group: Antibacterials for systemic use, carbapenems, ATC code: J01DH04.
Slovenian: Farmakoterapevtska skupina: zdravila za sistemsko zdravljenje bakterijskih infekcij, karbapenemi, oznaka ATC: J01DH04.
English: If the submission of a PSUR and the update of a RMP coincide, they can be submitted at the same
Slovenian: Če predložitev PSUR in posodobitev RMP sovpadata, se ju lahko predloži istočasno.
English: Chemical and physical in-use stability has been demonstrated for the times and solutions shown in the
Slovenian: Kemična in fizikalna stabilnost zdravila med uporabo je bila dokazana za čas in vrste raztopin, ki so navedene v zgornji preglednici.
English: This leaflet was last revised in MM/YYYY
Slovenian: Navodilo je bilo nazadnje revidirano MM/LLLL.
English: The selection of doripenem to treat an individual patient should take into account the appropriateness of using a carbapenem antibacterial agent based on factors such as severity of the infection, the prevalence of resistance to other suitable antibacterial agents and the risk of selecting for carbapenem-resistant bacteria.
Slovenian: Pri izbiri doripenema za zdravljenje pri posameznih bolnikih moramo upoštevati primernost uporabe karbapenemskih protibakterijskih zdravil na podlagi dejavnikov kot so resnost okužbe, prevalenca rezistence na druga primerna protibakterijska zdravila in tveganje pri izbiri karbapenemskih protibakterijskih zdravil.
English: Mean plasma terminal elimination half-life of doripenem in healthy young adults is approximately 1 hour and plasma clearance is approximately 15.9 l/hour.
Slovenian: Srednja končna plazemska razpolovna doba izločanja doripenema pri zdravih mladih odraslih znaša približno 1 uro, njegov plazemski očistek pa je približno 15,9 l/uro.
English: The study was stopped early based on the recommendation of an independent data monitoring committee.
Slovenian: Na osnovi priporočil neodvisne komisije, ki je spremljala podatke, so študijo predčasno zaključili.
English: Animal studies are insufficient with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Slovenian: Študije na živalih ne zadostujejo za oceno vpliva na nosečnost, razvoj zarodka/plodu, porod ali postnatalni razvoj (glejte poglavje 5.3).
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with Doribax should be made taking into account the benefit of breast-feeding to the child and the benefit of Doribax therapy to the woman.
Slovenian: Odločitev o tem, ali naj ženska nadaljuje/preneha z dojenjem oziroma ali naj nadaljuje/prekine zdravljenje z zdravilom Doribax, je treba sprejeti z upoštevanjem koristi dojenja za otroka in koristi zdravljenja z zdravilom Doribax za mater.
English: Based on in vitro studies it is not expected that doripenem will inhibit or induce the activities of CYP450.
Slovenian: Na osnovi in vitro študij ni pričakovati, da bi doripenem zaviral ali induciral delovanje CYP450.
English: Other medicines and Doribax
Slovenian: Druga zdravila in zdravilo Doribax
English: The effect of race on doripenem pharmacokinetics was examined through a population pharmacokinetic analysis.
Slovenian: Vpliv rase na farmakokinetiko doripenema so proučevali z analizo populacijske farmakokinetike.
English: Doribax should not be inhaled as it may cause inflammation of the lung (pneumonitis).
Slovenian: Zdravila Doribax se ne sme vdihovati, ker lahko povzroči vnetje pljuč (pneumonitis).
English: If you are not sure, talk to your doctor, pharmacist or nurse before being given Doribax.
Slovenian: Če niste prepričani, se posvetujte s svojim zdravnikom, s farmacevtom ali z medicinsko sestro, preden prejmete zdravilo Doribax.
English: Doribax is to be reconstituted and then further diluted (see section 6.6) prior to administration by intravenous infusion over a period of 1 or 4 hours.
Slovenian: Zdravilo Doribax je treba rekonstituirati in nato še dodatno razredčiti (glejte poglavje 6.6), preden ga daste bolniku z intravensko infuzijo v času 1 ali 4 ur.
English: A study in rats has shown that doripenem and its metabolite are transferred to milk.
Slovenian: Študija pri podganah je pokazala, da doripenem in njegov presnovek prehajata v materino mleko.
English: The usual treatment duration of doripenem therapy ranges from 5-14 days and should be guided by the severity, site of the infection, infecting pathogen and the patient's clinical response.
Slovenian: Običajno zdravljenje z doripenemom traja od 5-14 dni in je odvisno od resnosti in mesta okužbe, povzročitelja okužbe ter od bolnikovega kliničnega odziva.
English: What Doribax is and what it is used for
Slovenian: Kaj je zdravilo Doribax in za kaj ga uporabljamo
English: Doripenem AUC increased 49% in elderly adults relative to young adults.
Slovenian: Vrednost AUC za doripenem pri starejših odraslih je bila za 49 % višja kot pri mlajših odraslih.
English: * species against which activity has been demonstrated in clinical studies species that show natural intermediate susceptibility species with > 50% acquired resistance in one or more Member State ^ all methicillin-resistant staphylococci should be regarded as resistant to doripenem
Slovenian: vrste, proti katerim je bilo dokazano delovanje v kliničnih študijah vrste, ki so naravno intermediarno občutljive z > 50 % pridobljeno odpornostjo v eni ali več državah članicah ^ vse na meticilin rezistentne stafilokoke je treba obravnavati kot odporne na doripenem
English: Bacteroides fragilis Bacteroides caccae Bacteroides ovatus Bacteroides uniformis Bacteroides thetaiotaomicron Bacteroides vulgatus Bilophila wadsworthia Peptostreptococcus magnus Peptostreptococcus micros Porphyromonas spp.
Slovenian: Bacteroides fragilis* Bacteroides caccae* Bacteroides ovatus Bacteroides uniformis* Bacteroides thetaiotaomicron* Bacteroides vulgatus* Bilophilora wadsworthia Peptostreptococcus magnus Peptostreptococcus micros* Porphyromonas spp.
English: Powder for solution for infusion (powder for infusion)
Slovenian: prašek za raztopino za infundiranje (prašek za infundiranje)
English: In patients with mild renal impairment (i.e. creatinine clearance (CrCl) is > 50 to  80 ml/min), no dose adjustment is necessary.
Slovenian: Pri bolnikih z blago ledvično okvaro (očistek kreatinina (CrCl) je > 50 do ≤ 80 ml/min), prilagoditev odmerka ni potrebna.
English: An interaction with other medicinal products eliminated by renal tubular secretion cannot be excluded.
Slovenian: Interakcij z drugimi zdravili, ki se izločajo s tubulno sekrecijo preko ledvic, ne moremo izključiti.
English: CRRT: continuous renal replacement therapy; CVVH: continuous venovenous haemofiltration; CVVHDF: continuous venovenous haemodiafiltration; MIC: minimum inhibitory concentration
Slovenian: CRRT (continuous renal replacement therapy): kontinuirano nadomestno zdravljenje končne ledvične odpovedi; CVVH (continuous venovenous haemofiltration): kontinuirana veno-venska hemofiltracija; CVVHDF (continuous venovenous haemodiafiltration): kontinuirana veno-venska hemodiafiltracija; MIC (minimum inhibitory concentration): minimalna inhibitorna koncentracija.
English: other than S. pneumoniae
Slovenian: S. pneumoniae
English: As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable.
Slovenian: Po potrebi se posvetujte s specialistom, če je lokalna prevalenca odpornosti takšna, da je uporabnost antibiotika vprašljiva vsaj pri nekaterih vrstah okužb.
English: Pneumonitis with inhalational use
Slovenian: Pneumonitis zaradi uporabe zdravila z inhalacijo
English: Doribax should not be used during pregnancy unless clearly necessary.
Slovenian: Zdravilo Doribax se v času nosečnosti lahko uporablja le, če je nujno potrebno.
English: Doribax is supplied in packs of 10 vials.
Slovenian: Zdravilo Doribax je na voljo v pakiranjih po 10 vial.
English: Your doctor will monitor you for overgrowth and treat you if necessary.
Slovenian: Zdravnik vas bo spremljal, da pri vas ugotovi morebiten razrast mikroorganizmov in vas bo po potrebi ustrezno zdravil.
English: Mean renal clearance is 10.3 l/hour.
Slovenian: Srednji ledvični očistek doripenema znaša 10,3 l/uro.
English: If superinfection occurs, appropriate measures should be taken.
Slovenian: Če pride med zdravljenjem do superinfekcije, uvedite ustrezne ukrepe.
English: Of these, 50% had late-onset VAP (defined as that occurring after five days of mechanical ventilation), 54% had an APACHE (Acute Physiology And Chronic Health Evaluation) II score > 15 and 32% received concomitant aminoglycosides (76% for more than 3 days).
Slovenian: Od tega jih je imelo 50 % pozen pojav pljučnice (opredeljeno kot pojav pljučnice po petih dneh mehanske ventilacije), 54 % jih je imelo oceno APACHE (Acute Physiology And Chronic Health Evaluation) II > 15 in 32 % jih je sočasno prejemalo aminoglikozide (76 % več kot 3 dni).
English: Adverse drug reactions that led to Doribax discontinuation were nausea (0.1%), diarrhoea (0.1%), pruritus (0.1%), vulvomycotic infection (0.1%), hepatic enzyme increased (0.2%) and rash (0.2%).
Slovenian: Neželeni učinki, ki so vodili do ukinitve zdravila Doribax, so bili navzea (0,1 %), driska (0,1 %), pruritus (0,1 %), glivična okužba vulve (0,1 %), zvišanje vrednosti jetrnih encimov (0,2 %) in izpuščaj (0,2 %).
English: The effect of gender on the pharmacokinetics of doripenem was evaluated in healthy male and female subjects.
Slovenian: Vpliv spola na farmakokinetiko doripenema so ocenili pri zdravih moških in ženskah.
English: It is unknown whether doripenem is excreted in human breast milk.
Slovenian: Ni znano, ali se doripenem izloča v materino mleko pri človeku.
English: Doripenem is stable to hydrolysis by most beta-lactamases, including penicillinases and cephalosporinases produced by gram-positive and gram-negative bacteria, with the exception of relatively rare carbapenem hydrolysing beta-lactamases.
Slovenian: Doripenem je odporen na hidrolizo z večino betalaktamaz, vključno s penicilinazami in cefalosporinazami, ki jih izdelujejo gram-pozitivne in gram-negativne bakterije, z izjemo razmeroma redkih betalaktamaz, ki hidrolizirajo karbapeneme.
English: Doribax was discontinued because of adverse drug reactions in 0.1% of patients overall.
Slovenian: Zaradi neželenih učinkov so zdravilo Doribax ukinili pri skupaj 0,1 % bolnikov.
English: The most common adverse reactions were headache (10%), diarrhoea (9%) and nausea (8%).
Slovenian: Najpogostejši neželeni učinki so bili glavobol (10 %), driska (9 %) in navzea (8 %).
English: Your doctor will decide whether you should use Doribax in combination with these other medicines.
Slovenian: Zdravnik se bo odločil ali lahko uporabljate zdravilo Doribax skupaj s temi zdravili.
English: Each dose is given over a period of one or four
Slovenian: Dajanje vsakega odmerka traja eno ali štiri ure.
English: The experience in patients who are severely immunocompromised, receiving immunosuppressive therapy, and patients with severe neutropenia is limited since this population was excluded from
Slovenian: Izkušnje pri bolnikih z zelo oslabljenim imunskim sistemom, bolnikih, ki prejemajo imunosupresivno zdravljenje in bolnikih s hudo nevtropenijo so omejene, ker je bila ta populacija izključena iz preskušanj faze III.
English: * 1 g every 8 hours as a 4-hour infusion may be considered in patients with augmented renal clearance (particularly those with creatinine clearance (CrCl) ≥ 150 ml/min) and/or in infections due to non-fermenting gram-negative pathogens (such as Pseudomonas spp.
Slovenian: * 1 g na 8 ur v obliki 4-urnega infundiranja pri bolnikih z okrepljenim ledvičnim očistkom (predvsem tisti z očistkom kreatinina (CrCl) ≥150 ml/min) in/ali z okužbo z nefermentirajočimi po Gramu negativnimi povzročitelji (kot so Pseudomonas spp.
English: Since patients were administered only four doses of doripenem, a further decrease of valproic acid levels with longer concomitant administration cannot be excluded.
Slovenian: Ker so bolniki prejeli samo štiri odmerke doripenema, ne moremo izključiti dodatnega zmanjšanja koncentracije valprojske kisline pri daljši sočasni uporabi.
English: As with other antimicrobial agents, including carbapenems, doripenem has been shown to select for resistant bacterial strains.
Slovenian: Kot pri drugih antibiotikih, vključno s karbapenemskimi, so pokazali, da doripenem povzroča selekcijo odpornih bakterijskih sevov.
English: The magnitude of this value, coupled with the significant decrease in the elimination of doripenem seen with concomitant probenecid administration, suggests that doripenem undergoes glomerular filtration, tubular secretion and re-absorption.
Slovenian: Velikost te vrednosti ter pomembno zmanjšanje izločanja doripenema, ki so ga opazili pri sočasni uporabi probenecida, kažeta, da se doripenem izloča z glomerulno filtracijo, s tubulno sekrecijo in se tudi reabsorbira.
English: Variations in colour within this range do not affect the potency of the product.
Slovenian: Takšne razlike v barvi zdravila ne vplivajo na njegovo jakost.
English: Caution on the choice of antibiotic agent and dose should be taken when treating patients with late-onset ventilator-associated pneumonia (> 5 days hospitalisation) and in other nosocomial pneumonia cases where pathogens with decreased susceptibility are suspected or confirmed, such as Pseudomonas spp.
Slovenian: Previdnost pri izbiri antibiotika in odmerku se priporoča pri zdravljenju bolnikov s poznim nastopom pljučnice zaradi uporabe respiratorja (> 5 dnevna hospitalizacija) in drugih bolnišničnih pljučnic, kjer se sumi na ali so potrjeni povzročitelji z zmanjšano občutljivostjo, kot npr. Pseudomonas spp.
English: However, no information is available on the use of either of these
Slovenian: Podatkov ni na voljo.
English: The concomitant use of doripenem and valproic acid/sodium valproate is not recommended (see section 4.5).
Slovenian: Sočasna uporaba doripenema in valprojske kisline/natrijevega valproata ni priporočljiva (glejte poglavje 4.5).
English: Probenecid competes with doripenem for renal tubular secretion and reduces the renal clearance of doripenem.
Slovenian: Probenecid tekmuje z doripenemom za ledvično tubulno sekrecijo in tako zmanjša ledvični očistek doripenema.
English: No significant difference in mean doripenem clearance was observed across race groups and therefore, no dose adjustment is recommended for race.
Slovenian: Med posameznimi rasnimi skupinami niso opazili značilnih razlik v srednjem očistku doripenema, zato prilagoditev odmerka zdravila glede na raso ni priporočena.
English: Monte Carlo simulations using pathogen susceptibility results from completed phase III trials and population PK data indicated that the %T>MIC target of 35% was achieved in greater than 90% of patients with nosocomial pneumonia, complicated urinary tract infections and complicated intra-abdominal infections, for all degrees of renal function.
Slovenian: Simulacije Monte Carlo, opravljene na podlagi izvidov občutljivosti posameznih patogenov iz zaključenih preskušanj III. faze in populacijski farmakokinetični podatki kažejo, da je bila tarčna vrednost %T> MIC 35 % dosežena pri več kot 90 % bolnikov z bolnišnično pljučnico, okužbami sečil z zapleti in intraabdominalnimi okužbami z zapleti za vse stopnje delovanja ledvic.
English: What you need to know before you use Doribax
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Doribax
English: Methicillin-resistant staphylococci should always be considered as resistant to doripenem.
Slovenian: Meticilin rezistentne stafilokoke je treba obravnavati kot rezistentne na doripenem.
English: Therefore, no CYP450-related drug interactions are to be expected (see section 5.2).
Slovenian: Zato pri njegovi uporabi ni pričakovati interakcij z drugimi zdravili prek vpliva na CYP450 (glejte poglavje 5.2).
English: For doripenem, limited clinical data on exposed pregnancies are available.
Slovenian: Klinični podatki o nosečnicah, ki so bile izpostavljene doripenemu, so omejeni.
English: The amount of doripenem and doripenem-M-1 removed during a 12-hour CVVH session was approximately 28% and 10% of the dose, respectively; and during a 12-hour CVVHDF session was approximately 21% and 8% of the dose, respectively.
Slovenian: Količina doripenema in doripenema-M-1, odstranjena med 12-urno CVVH je znašala približno 28 % in 10 % odmerka, med 12-urno CVVHDF pa približno 21 % in 8 % odmerka.
English: The rash resolved within 10 days after doripenem administration was discontinued.
Slovenian: Izpuščaj je izginil v 10 dneh po prekinitvi uporabe doripenema.
English: Seizures in clinical trials with doripenem occurred most commonly in those with pre-existing central nervous system (CNS) disorders (e.g. stroke or history of seizures), compromised renal function and at doses greater than 500 mg.
Slovenian: V kliničnih študijah z doripenemom so bili epileptični napadi najpogostejši pri tistih z obstoječimi motnjami v centralnem živčnem sistemu (CŽS) (npr. kap ali epileptični napadi v anamnezi), oslabljenim delovanjem ledvic in pri uporabi odmerkov, večjih od 500 mg.
English: Concomitant use of an aminoglycoside may be indicated when Pseudomonas aeruginosa infections are suspected or proven to be involved in the approved indications (see section 4.1).
Slovenian: Sočasna uporaba aminoglikozidov je indicirana ob sumu ali potrditvi okužbe s Pseudomonas aeruginosa in v okviru odobrenih indikacij (glejte poglavje 4.1).
English: Target attainment (MIC)
Slovenian: Ciljna vrednost (MIC)
English: In patients prescribed 1 g every 8 hours as a 4-hour infusion, the dose should be similarly adjusted (moderate renal impairment: 500 mg every 8 hours; severe renal impairment: 500 mg every 12 hours).
Slovenian: Bolnikom, katerim predpišejo 1 g na 8 ur v obliki 4-urnega infundiranja, je treba podobno prilagoditi odmerek (zmerna lokvara ledvic: 500 mg na 8 ur; huda ledvična okvara: 500 mg na 12 ur).
English: Uncommon side effects (may affect up to 1 in 100 people): - Decrease of blood platelet count which may increase your risk of bruising and bleeding - Decrease of white blood cells which may increase your risk of infections
Slovenian: Občasni neželeni učinki (pojavijo se lahko pri največ 1 od 100 bolnikov): - zmanjšanje števila trombocitov, kar lahko poveča tveganje za nastanek poškodb in krvavitev, - zmanjšanje števila belih krvničk, ki lahko poveča nagnjenost k okužbam, - epileptični napadi
English: Following the administration of a single 500 mg dose of radiolabeled doripenem to healthy young adults, less than 1% of the total radioactivity was recovered in faeces.
Slovenian: Po aplikaciji enkratnega 500 mg odmerka radioaktivno označenega doripenema zdravim mladim odraslim so v blatu našli manj kot 1 % skupne radioaktivnosti.
English: No studies on the effects of Doribax on the ability to drive and use machines have been performed.
Slovenian: Študij o vplivu zdravila Doribax na sposobnost vožnje in upravljanja s stroji niso izvedli.
English: Eleven percent had an APACHE II score of > 10, 9.5% had post-operative infections, 27% had single or multiple intra-abdominal abscesses and 4% had concurrent bacteraemia at baseline.
Slovenian: Na začetku študije je imelo 11 % bolnikov oceno APACHE II > 10, 9,5 % jih je imelo postoperativne okužbe, 27 % bolnikov je imelo enega ali več intraabdominalnih abscesov in 4 % bolnikov so imeli sočasno bakteriemijo.
English: Staphylococcus aureus (methicillin susceptible strains only) Staphylococcus spp.
Slovenian: Staphylococcus aureus (samo za meticilin občutljivi sevi)*^ Staphylococcus spp.
English: Serious acute hypersensitivity (anaphylactic) reactions require immediate
Slovenian: Pri resnih akutnih preobčutljivostnih (anafilaktičnih) reakcijah je potrebno takojšnje urgentno zdravljenje.
English: These dosing recommendations were derived by modeling data from subjects with end stage renal disease receiving continuous renal replacement therapy, and take into consideration the potential increases in non-renal clearance of carbapenems in patients with acute renal insufficiency compared to patients with chronic renal impairment.
Slovenian: Priporočila za odmerjanje so pripravljena z modeliranjem podatkov preiskovancev s končno ledvično odpovedjo na kontinuiranem nadomestnem zdravljenju, z upoštevanjem možnih zvečanj ne-ledvičnega očistka karbapenemov pri bolnikih z akutno ledvično odpovedjo v primerjavi z bolniki s kronično ledvično odpovedjo.
English: Species resistant to other carbapenems do generally express co-resistance to doripenem.
Slovenian: Vrste, ki so rezistentne na druge karbapeneme, večinoma izkazujejo tudi rezistenco na doripenem.
English: Adverse drug reactions identified during clinical trials and post-marketing experience with Doribax are listed below by frequency category.
Slovenian: Neželeni učinki, o katerih so poročali med kliničnimi preskušanji in v obdobju trženja zdravila Doribax so našteti spodaj po kategorijah pogostnosti.
English: Doripenem is a synthetic carbapenem antibacterial agent.
Slovenian: Mehanizem delovanja Doripenem je sintetična karbapenemska protimikrobna učinkovina.
English: Very common side effects (may affect more than 1 in 10 people):
Slovenian: Zelo pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 10 bolnikov): - glavobol
English: Time by which reconstitution, dilution and infusion must be completed for Doribax infusions solutions
Slovenian: Čas, v katerem je treba končati rekonstitucijo, redčenje in infundiranje infuzijskih raztopin zdravila Doribax
English: S  1 mg/l and R > 4 mg/l
Slovenian: S  1 mg/l in R > 4 mg/l
English: Doripenem is primarily eliminated unchanged by the kidneys.
Slovenian: Doripenem se izloča predvsem v nespremenjeni obliki preko ledvic.
English: - Your doctor will decide how much Doribax you need and for how long.
Slovenian: Koliko zdravila Doribax uporabimo - Vaš zdravnik bo presodil, koliko zdravila Doribax potrebujete in koliko časa bo trajalo zdravljenje.
English: Do not use this medicine if any of the above applies to you.
Slovenian: Če se karkoli od zgoraj navedenega nanaša na vas, tega zdravila ne smete uporabljati.
English: In 3,142 adult patients (1,817 of which received Doribax) evaluated for safety in phase II and phase III clinical trials, adverse reactions due to Doribax 500 mg every 8 hours occurred at a rate of 32%.
Slovenian: Pri 3.142 odraslih bolnikih (od tega jih je 1.817 prejemalo zdravilo Doribax), pri katerih so ocenjevali varnost zdravil v kliničnih preskušanjih faze II in III, so se neželeni učinki zdravila Doribax v odmerku 500 mg na 8 ur pojavljali z 32 % pogostnostjo.
English: - If you get bloody diarrhoea before, during or after your treatment with Doribax (Clostridium
Slovenian: - krvava driska pred, med ali po zdravljenju z zdravilom Doribax (kolitis zaradi razrasta bakterije
English: Monte Carlo simulations supported the use of 500 mg 4-hour infusions every 8 hours in subjects with normal renal function for target pathogens with doripenem MICs  4 mg/l.
Slovenian: Simulacije Monte Carlo govorijo v prid uporabi 500 mg odmerka doripenema v 4-urni infuziji na 8 ur pri preiskovancih z normalnim delovanjem ledvic za ciljne patogene z vrednostmi MIC doripenema  4 mg/l.