FrancophonIA/ELRC3.0 huggingface dataset:
English: Outcome for patients without SVR On-treatment virologic failure Relapseb Otherc SVR rates for selected subgroups Patients with cirrhosis Previously treated patients with cirrhosis a 8 patients with genotype 4 HCV infection were enrolled in the study with 8/8 achieving SVR12.
Croatian: U ispitivanje je bilo uključeno 8 bolesnika s infekcijom HCV-om genotipa 4; 8/8 ih je postiglo SVR12. b. Nazivnik za relaps je broj bolesnika s HCV RNK < LLOQ na njihovom posljednjem pregledu za vrijeme trajanja terapije.
English: Ledipasvir ↓ Cmax 0.65 (0.56, 0.76)
Croatian: Ledipasvir ↓ Cmax 0,66 (0,59; 0,75) ↓ AUC 0,66 (0,59; 0,75) ↓ Cmin 0,66 (0,57; 0,76)
English: ↔ Cmin 0.94 (0.77, 1.14) S-methadone ↔ Cmax 0.95 (0.79, 1.13)
Croatian: ↔ Cmax 0,95 (0,79; 1,13) ↔ AUC 0,95 (0,77; 1,17) ↔ Cmin 0,95 (0,74; 1,22)
English: ↔ Cmin 1.04 (0.98, 1.11) Tenofovir ↑ Cmax 1.79 (1.56, 2.04)
Croatian: Tenofovir ↑ Cmax 1,79 (1,56; 2,04) ↑ AUC 1,98 (1,77; 2,23) ↑ Cmin 2,63 (2,32; 2,97)
English: GS-331007 ↔ Cmax 0.97 (0.83, 1.14)
Croatian: GS-331007 ↔ Cmax 0,97 (0,83; 1,14) ↔ AUC 1,00 (0,87; 1,13)
English: Sofosbuvir ↔ Cmax 1.12 (0.88, 1.42)
Croatian: Sofosbuvir ↔ Cmax 1,12 (0,88; 1,42) ↔ AUC 1,00 (0,80; 1,25)
English: Norelgestromin ↔ Cmax 1.02 (0.89, 1.16)
Croatian: Norelgestromin ↔ Cmax 1,02 (0,89; 1,16) ↔ AUC 1,03 (0,90; 1,18) ↔ Cmin 1,09 (0,91; 1,31)
English: GS-331007 ↔ Cmax 1.06 (0.97, 1.14)
Croatian: GS-331007 ↔ Cmax 1,06 (0,97; 1,14) ↔ AUC 1,06 (1,02; 1,11)
English: Tacrolimus ↓ Cmax 0.73 (0.59, 0.90)
Croatian: Sofosbuvir ↓ Cmax 0,63 (0,52; 0,75) ↓ AUC 0,73 (0,65; 0,82)
English: GS-331007 ↔ Cmax 0.97 (0.90, 1.05)
Croatian: GS-331007 ↔ Cmax 0,97 (0,90; 1,05) ↔ AUC 1,24 (1,18; 1,30)
English: ↔ Cmin 1.12 (1.03, 1.21) Tenofovir ↔ Cmax 1.32 (1.25, 1.39)
Croatian: Tenofovir ↔ Cmax 1,32 (1,25; 1,39) ↑ AUC 1,40 (1,31; 1,50) ↑ Cmin 1,91 (1,74; 2,10)
English: ↑ Cmin 1.59 (1.49, 1.70) Ledipasvir ↔ Cmax 1.11 (0.99, 1.24)
Croatian: Tenofovir ↑ Cmax 1,64 (1,54; 1,74) ↑ AUC 1,50 (1,42; 1,59) ↑ Cmin 1,59 (1,49; 1,70)
English: ↔ Cmin 0.97 (0.86, 1.10) Ledipasvir ↑ Cmax 1.45 (1.34, 1.56)
Croatian: Sofosbuvir ↑ Cmax 1,45 (1,10; 1,92) ↑ AUC 1,34 (1,12; 1,59)
English: Sofosbuvir ↓ Cmax 0.64 (0.53, 0.77)
Croatian: Sofosbuvir ↓ Cmax 0,64 (0,53; 0,77) ↓ AUC 0,76 (0,63; 0,91) Cmin (NA)
English: ↔ Cmin 1.07 (0.89, 1.28) Norgestrel ↔ Cmax 1.18 (0.99, 1.41)
Croatian: Norgestrel ↔ Cmax 1,03 (0,87; 1,23) ↔ AUC 0,99 (0,82; 1,20) ↔ Cmin 1,00 (0,81; 1,23)
English: Not interpretable a One patient in the LDV/SOF 8-week treatment arm did not have a confirmed genotype 1 subtype.
Croatian: U jednog bolesnika u terapijskoj skupini liječenoj 8 tjedana LDV/SOF-om nije bila potvrđena podvrsta genotipa 1. b. Rezultati FibroTesta koji nisu nedostajali bili su mapirani na Metavir-rezultate prema sljedećem: 0-0,31 = F0-F1;
English: EXP
Croatian: Ostaloc
English: ↔ Cmin 1.16 (1.08, 1.25) Sofosbuvir ↔ Cmax 1.05 (0.93, 1.20)
Croatian: Sofosbuvir ↔ Cmax 1,08 (0,85; 1,35) ↔ AUC 1,21 (1,09; 1,35)
English: ↔ Cmin 1.12 (1.05, 1.20) Ledipasvir ↔ Cmax 1.10 (1.01, 1.19)
Croatian: Sofosbuvir ↔ Cmax 1,05 (0,93; 1,20) ↔ AUC 1,10 (1,01; 1,21)
English: Ciclosporin ↔ Cmax 1.06 (0.94, 1.18)
Croatian: Ciklosporin ↔ Cmax 1,06 (0,94; 1,18) ↔ AUC 0,98 (0,85; 1,14)
English: ↔ Cmin 0.91 (0.83, 0.99) Emtricitabine ↔ Cmax 1.08 (0.97, 1.21)
Croatian: Emtricitabin ↔ Cmax 1,02 (0,96; 1,08) ↔ AUC 1,04 (1,00; 1,08) ↔ Cmin 1,03 (0,97; 1,10)
English: (Inhibition of CYP3A) Midazolam ↔ Cmax 0.95 (0.87, 1.04)
Croatian: Midazolam ↔ Cmax 0,95 (0,87; 1,04) ↔ AUC 0,89 (0,84; 0,95) (Indukcija CYP3A)
English: ↑ Cmin 2.18 (1.91, 2.50) Sofosbuvir ↔ Cmax 1.01 (0.88, 1.15)
Croatian: Sofosbuvir ↔ Cmax 1,01 (0,88; 1,15) ↔ AUC 1,11 (1,02; 1,21)
English: f Staggered administration (12 hours apart) of atazanavir/ritonavir + emtricitabine/tenofovir disoproxil fumarate or darunavir/ritonavir + emtricitabine/tenofovir disoproxil fumarate and Harvoni provided similar results.
Croatian: + emtricitabin/tenofovirdizoproksilfumarata ili darunavira/ritonavira
English: ↔ Cmin 0.95 (0.81, 1.12) Sofosbuvir ↔ Cmax 0.87 (0.71, 1.08)
Croatian: Sofosbuvir ↔ Cmax 0,96 (0,88; 1,05) ↔ AUC 1,08 (1,02; 1,15)
English: ↔ Cmin 1.08 (0.98, 1.20) Ritonavir ↔ Cmax 1.17 (1.01, 1.35)
Croatian: Ledipasvir ↔ Cmax 1,01 (0,95; 1,07) ↔ AUC 1,08 (1,02; 1,15) ↔ Cmin 1,16 (1,08; 1,25)
English: ↔ Cmin 1.26 (1.17, 1.36) Sofosbuvir ↔ Cmax 1.08 (0.85, 1.35)
Croatian: Sofosbuvir ↔ Cmax 1,00 (0,76; 1,32) ↔ AUC 0,95 (0,82; 1,10)
English: HIV ANTIVIRAL AGENTS: REVERSE TRANSCRIPTASE INHIBITORS Efavirenz/ emtricitabine/ tenofovir disoproxil fumarate (600 mg/ 200 mg/ 300 mg/ once daily)/ ledipasvir (90 mg once daily)c/ sofosbuvir (400 mg once daily)c, d
Croatian: Efavirenz/ emtricitabin/ tenofovirdizoproksilfumarat (600 mg/ 200 mg/ 300 mg/ jedanput na dan)/ ledipasvir (90 mg jedanput na dan)c/ sofosbuvir (400 mg jedanput na dan)c, d
English: ↔ Cmin 1.06 (0.97, 1.15) Rilpivirine ↔ Cmax 0.97 (0.88, 1.07)
Croatian: Emtricitabin ↔ Cmax 1,02 (0,98; 1,06) ↔ AUC 1,05 (1,02; 1,08) ↔ Cmin 1,06 (0,97; 1,15)
English: Copovidone
Croatian: Okskarbazepin
English: ↑ Cmin 1.36 (1.23, 1.49) Cobicistat ↔ Cmax 1.25 (1.18, 1.32)
Croatian: Kobicistat ↔ Cmax 1,25 (1,18; 1,32) ↑ AUC 1,59 (1,49; 1,70) ↑ Cmin 4,25 (3,47; 5,22)
English: GS-331007 ↔ Cmax 1.23 (1.14, 1.34)
Croatian: GS-331007 ↔ Cmax 1,23 (1,14; 1,34) ↔ AUC 0,95 (0,88; 1,03)
English: ↑ Cmin 1.15 (0.90, 1.46) Ledipasvir ↔ Cmax 0.92 (0.85, 1.00)
Croatian: Raltegravir ↓ Cmax 0,82 (0,66; 1,02) ↔ AUC 0,85 (0,70; 1,02) ↑ Cmin 1,15 (0,90; 1,46)
English: Excipients
Croatian: Pravastatin
English: Darunavir ↔ Cmax 0.97 (0.94, 1.01)
Croatian: Darunavir ↔ Cmax 0,97 (0,94; 1,01) ↔ AUC 0,97 (0,94; 1,00) ↔ Cmin 0,86 (0,78; 0,96)
English: Ledipasvir ↑ Cmax 1.98 (1.78, 2.20)
Croatian: Ledipasvir ↑ Cmax 1,98 (1,78; 2,20) ↑ AUC 2,13 (1,89; 2,40) ↑ Cmin 2,36 (2,08; 2,67)
English: ↑ Cmin 1.48 (1.34, 1.63) Emtricitabine ↔ Cmax 1.02 (0.96, 1.08)
Croatian: Emtricitabin ↔ Cmax 0,98 (0,94; 1,02) ↔ AUC 1,00 (0,97; 1,04) ↔ Cmin 1,04 (0,96; 1,12)
English: ↔ Cmin 0.95 (0.74, 1.22) Sofosbuvir ↓ Cmax 0.95 (0.68, 1.33)
Croatian: Sofosbuvir ↔ Cmax 0,87 (0,71; 1,08) ↔ AUC 0,95 (0,82; 1,09)
English: These effects usually do not last longer than 30 minutes.
Croatian: Ovi učinci obično ne traju duže od 30 minuta.
English: • if you are pregnant, think you are pregnant or planning to have a baby.
Croatian: • ako ste trudni, mislite da biste mogli biti trudni ili planirate imate dijete.
English: Rapiscan with food and drink
Croatian: Rapiscan s hranom i pićem
English: They don't usually need any treatment.
Croatian: Obično ne zahtijevaju liječenje.
English: 400 micrograms
Croatian: 400 mikrograma
English: The half-life of this initial phase is approximately 2 to 4 minutes.
Croatian: Poluvijek ove inicijalne faze iznosi oko 2 do 4 minute.
English: Regadenoson should not be used during pregnancy unless clearly necessary.
Croatian: Regadenoson se ne bi smio primjenjivati tijekom trudnoće osim ako to nije izričito potrebno.
English: Harmful effects have been seen in animal studies but it is not known if there is a risk to humans.
Croatian: Primijećeni su štetni učinci u ispitivanjima na životinjama, ali nije poznato postoji li rizik za ljude.
English: NO-0485 Oslo Norway
Croatian: NO-0485 Oslo Norveška
English: Classification agreement Cohen's kappa
Croatian: Klasifikacijsko slaganje Cohen's kappa
English: The doctor, nurse or medical technician will let you know when you can stand up.
Croatian: Liječnik, medicinska sestra ili medicinski tehničar reći će Vam kad smijete ustati.
English: For the measurement of FFR, five independent studies have been conducted.
Croatian: Za mjerenje FFR-a provedeno je pet neovisnih studija.
English: Patients initiated exercise using a standard or modified Bruce protocol.
Croatian: Bolesnici su započeli vježbu primjenom standardnog ili modificiranog Bruce-ovog protokola.
English: Stolker et al. 2015 (n=149) van Nunen et al. 2015 (n=98)
Croatian: Stolker i sur., 2015 (n=149) van Nunen i sur., 2015 (n=98)
English: The data are insufficient to conclude about the risk of interactions at the level of these transporters given that a single concentration was evaluated in most instances.
Croatian: Podaci nisu dovoljni za donošenje zaključka o riziku interakcija na razini tih transportera s obzirom da je u većini slučajeva procijenjena jedna koncentracija.
English: Multiple injections
Croatian: Višestruke injekcije
English: Tell your doctor straight away if you think you are having severe side effects.
Croatian: Odmah recite svom liječniku ako mislite da imate teške nuspojave.
English: Effect of caffeine
Croatian: Učinak kofeina
English: These measures will help to protect the environment .
Croatian: Ove će mjere pomoći u očuvanju okoliša.
English: This is because caffeine can interfere with the effect of Rapiscan.
Croatian: To je zato što kofein može interferirati s učinkom Rapiscana.
English: Particular care should be taken with the following medicines:
Croatian: Posebno treba biti oprezan kod uzimanja sljedećih lijekova:
English: Do not eat food or have drinks containing caffeine (for example, tea, coffee, cocoa, cola or chocolate) for at least 12 hours before you are given Rapiscan.
Croatian: Nemojte jesti hranu ili piti pića koja sadrže kofein (primjerice čaj, kavu, kakao, kolu ili čokoladu) najmanje 12 sati prije nego primite Rapiscan.
English: The median time between scans was 7 days (range of 1-104 days).
Croatian: Medijan vremena između dva snimanja bila je 7 dana (raspon 1-104 dana).
English: Images are then taken of the heart.
Croatian: Potom se slika srce.
English: Children and adolescents Rapiscan should not be used in children and adolescents below the age of 18 years.
Croatian: Rapiscan se ne bi smio koristiti u djece i adolescenata mlađih od 18 godina.
English: If you are given more Rapiscan than you should
Croatian: Ako primite više Rapiscana nego što ste trebali
English: However, given the proposed duration of use, the effects of the drug transporters are unlikely to be clinically relevant.
Croatian: Međutim, s obzirom na preporučeno trajanje primjene, učinci transportera lijeka vjerojatno neće biti klinički relevantni.
English: This leaflet was last revised in MM/YYYY
Croatian: Ova uputa je zadnji puta revidirana u MM/GGGG
English: Sensitivity Specificity
Croatian: Osjetljivost Specifičnost
English: Safety and tolerability testing
Croatian: Testiranje sigurnosti i podnošljivosti
English: Hyperaemia may fluctuate between sub-maximum and maximum until it slowly vanishes.
Croatian: Hiperemija može fluktuirati između submaksimalne i maksimalne dok polako ne nestane.
English: However, the maximum observed plasma concentrations as well as volumes of distribution estimates were similar across the groups.
Croatian: Ipak, zabilježena maksimalna koncentracija u plazmi kao i procjene volumena distribucije bili su slični u svim skupinama.
English: What Rapiscan is and what it is used for
Croatian: Što je Rapiscan i za što se koristi
English: PACKAGE LEAFLET: INFORMATION FOR THE USER
Croatian: Uputa o lijeku: Informacije za korisnika
English: They normally start soon after the Rapiscan injection and are usually over within 30 minutes.
Croatian: Obično se javljaju odmah nakon injekcije Rapiscana i obično prolaze unutar 30 minuta.
English: Other medicines and Rapiscan
Croatian: Drugi lijekovi i Rapiscan
English: Adverse reactions occurred in approximately 80% of patients.
Croatian: Nuspojave su se javljale u oko 80% bolesnika.
English: The dose injected does not depend on your weight.
Croatian: Injicirana doza ne ovisi o Vašoj tjelesnoj težini.
English: Dyspnoea did not correlate with a decrease in FEV1.
Croatian: Dispneja nije korelirala sa smanjenjem FEV1.
English: Adenosine was treated as a gold standard to estimate sensitivity, specificity, and the proportion of accuracy.
Croatian: Adenozin je uzet kao zlatni standard kako bi se procijenila osjetljivost, specifičnost i omjer točnosti.
English: If any of these apply to you, tell your doctor before you are given the injection.
Croatian: Ako se bilo što od navedenog odnosi na Vas, recite to svom liječniku prije nego primite injekciju.
English: The side effects are usually mild.
Croatian: Nuspojave su obično blage.
English: Do not drive or operate machinery until these effects have improved.
Croatian: Nemojte voziti, rukovati alatima niti strojevima dok ovi učinci ne prođu.
English: Your doctor will only give you Rapiscan if it is clearly necessary.
Croatian: Vaš će Vam liječnik dati Rapiscan samo ako je to neophodno.
English: Distribution Regadenoson is moderately bound to human plasma proteins (25-30%).
Croatian: Distribucija Regadenoson se umjereno veže na proteine plazme u ljudi (25-30%).
English: • if you have low blood pressure (hypotension).
Croatian: - ako imate niski krvni tlak (hipotenziju).
English: This belongs to a group of medicines called ‘coronary vasodilators'.
Croatian: Pripada skupini lijekova koji se nazivaju "koronarni vazodilatatori".
English: Bronchoconstriction
Croatian: Bronhokonstrikcija
English: Respiratory effects
Croatian: Respiratorni učinci
English: The terminal phase consists of a decline in plasma concentration with a half-life of approximately 2 hours.
Croatian: Terminalna faza sastoji se od pada koncentracije u plazmi s poluvijekom od oko 2 sata.
English: You should avoid breast-feeding for at least 10 hours after you are given Rapiscan.
Croatian: Morate izbjegavati dojiti barem 10 sati nakon što primite Rapiscan.
English: What you need to know before you are given Rapiscan
Croatian: Što morate znati prije nego primite Rapiscan
English: When administered twice 10 minutes apart in a 24-hour period, full safety data for the second injection of Rapiscan are not available.
Croatian: Kod primjene dva puta u razmaku od 10 minuta tijekom razdoblja od 24 sata, kompletni sigurnosni podaci za drugu injekciju Rapiscana nisu dostupni.
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10) uncommon (≥ 1/1,000 to < 1/100) and rare (≥ 1/10,000 to < 1/1,000).
Croatian: Učestalost je definirana kao vrlo često (≥ 1/10), često (≥ 1/100 do < 1/10), manje često (≥ 1/1000 do < 1/100) i rijetko (≥ 1/10 000 do < 1/1000).
English: AndersonBrecon (UK) Ltd Wye Valley Business Park Hay-on-Wye, Hereford HR3 5PG, United Kingdom
Croatian: AndersonBrecon (UK) Ltd Wye Valley Business Park Hay-on-Wye, Hereford HR3 5PG,
English: It may cause other symptoms (headache or shortness of breath) that could affect your ability to drive or use machinery.
Croatian: Može uzrokovati i druge simptome (glavobolju ili nedostatak zraka) koji mogu utjecati na Vašu sposobnost upravljanja vozilima i strojevima.
English: Rarely, Rapiscan can cause a stroke (also known as a cerebrovascular accident).
Croatian: Rijetko, Rapiscan može uzrokovati moždani udar (što se naziva i cerebrovaskularnim inzultom).
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, single and repeated dose toxicity, genotoxicity, or embryo-fetal development.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti pojedinačnih i ponovljenih doza, genotoksičnosti ili embriofetalnog razvoja.
English: Repeat dosing within 10 minutes - except in patients where the duration of hyperaemia lasted for more than 10 minutes - caused a similar effect on peak and duration of maximum hyperaemia.
Croatian: Ponovljeno doziranje unutar 10 minuta - osim kod bolesnika kod kojih je trajanje hiperemije bilo dulje od 10 minuta - imalo je sličan učinak na vrhunac i trajanje maksimalne hiperemije.
English: • ringing in the ears
Croatian: • zujanje u ušima
English: • if you have a condition that causes fits (seizures), such as epilepsy, or if you have ever had fits.
Croatian: • ako imate stanje koje uzrokuje napadaje (konvulzije), kao što je epilepsija, ili ako ste ikada imali napadaje.
English: Your doctor may then give you an injection of a medicine called aminophylline that reduces these effects.
Croatian: Liječnik Vam tada može dati injekciju lijeka zvanog aminofilin koji će smanjiti ove učinke.
English: During the exercise, a small amount of radiopharmaceutical is injected into the body, often into a vein in the hand.
Croatian: Za vrijeme napora mala količina radiofarmaceutika se ubrizga u tijelo, obično kroz venu na ruci.
English: An intermediate phase follows, with a half-life on average of 30 minutes coinciding with loss of the pharmacodynamic effect.
Croatian: Slijedi intermedijalna faza s poluvijekom koji u prosjeku iznosi 30 minuta, a podudara se s gubitkom farmakodinamičkog učinka.
English: Most increases resolved within 10 to 15 minutes, but in some cases, increases were observed at 45 minutes following administration.
Croatian: Većina povišenja povukla se unutar 10 do 15 minuta, ali u nekim slučajevima povišenja su primijećena 45 minuta nakon primjene.
English: • if you have any heart or blood vessel condition, particularly one that gets worse when your blood pressure decreases.
Croatian: • ako bolujete od bilo kojeg stanja srca ili krvnih žila, posebno onog koje se pogorša kada se snizi krvni tlak.
English: A decision should be made whether to discontinue breastfeeding or to abstain from regadenoson administration taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je odlučiti da li prekinuti dojenje ili suzdržati se od primjene regadenosona uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: The radiopharmaceutical may be injected directly into the same catheter as Rapiscan.
Croatian: Radiofarmaceutik se može ubrizgati izravno kroz istu kanilu kao i Rapiscan.
English: • if you have chest pain that occurs unpredictably (unstable angina) and that has not improved after treatment.
Croatian: - ako imate bol u prsnom košu koja nastaje nepredvidivo (nestabilna angina) i koja se nije poboljšala nakon liječenja.
English: Mean APV increased to greater than twice baseline by 30 seconds and decreased to less than half of the maximal effect within 10 minutes (see section 5.2).
Croatian: Srednji APV porastao je više od dva puta od polaznih vrijednosti za 30 sekundi, i pao na manje od polovice maksimalne dostignute vrijednosti unutar 10 minuta (vidjeti dio 5.2).
English: What Rapiscan looks like and contents of the pack
Croatian: Kako Rapiscan izgleda i sadržaj pakiranja
English: In the measurement of FFR, the time to peak maximum hyperaemia was 30±13 seconds.
Croatian: U mjerenju FFR-a vrijeme do vrhunca maksimalne hiperemije bilo je 30±13 sekundi.
English: • discomfort in the bones and muscles
Croatian: • nelagoda u kostima i mišićima
English: • Severe hypotension.
Croatian: • Izrazita hipotenzija.
English: • difficulty in breathing (bronchospasm)
Croatian: • otežano disanje (bronhospazam)
English: It is not known whether Rapiscan can pass into breast milk and will only be given to you if your doctor thinks it is necessary.
Croatian: Nije poznato izlučuje li se Rapiscan u majčino mlijeko i bit će Vam dan samo ako Vaš liječnik smatra da je potrebno.
English: Pregnancy and breast-feeding Before you are given Rapiscan, tell your doctor:
Croatian: Trudnoća i dojenje Prije nego primite Rapiscan obratite se svom liječniku:
English: fluttering, or beating too hard or fast (palpitations)
Croatian: treperenje srca, prejako ili prebrzo kucanje (palpitacije)
English: Rapiscan may make you feel dizzy.
Croatian: Rapiscan može učiniti da osjećate omaglicu.
English: • if you have asthma or lung disease.
Croatian: • ako bolujete od astme ili bolesti pluća.
English: Like all medicines, Rapiscan can cause side effects, although not everybody gets them.
Croatian: Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave iako se one neće javiti kod svakoga.
English: • if you have a heart rhythm disorder called long QT syndrome.
Croatian: • ako imate poremećaj srčanog ritma zvan sindrom produženog QT intervala.
English: Your heart rate and blood pressure will be monitored.
Croatian: Nadzirat će se Vaš puls i krvni tlak.
English: • anxiety, difficulty sleeping
Croatian: • anksioznost, smetnje spavanja
English: The regadenoson plasma concentration-time profile in healthy volunteers is multi-exponential in nature and best characterised by 3-compartment model.
Croatian: Profil koncentracije regadenosona u plazmi u zdravih dragovoljaca je po prirodi multieksponencijalan i najbolje se opisuje modelom 3 odjeljka.
English: A scan of your heart will be made after enough time has passed to allow the radiopharmaceutical to reach the heart muscle.
Croatian: Snimanje srca učinit će se kad prođe dovoljno vremena koje omogućuje da radiofarmaceutik dospije do srčanog mišića.
English: Fetotoxicity, but not teratogenicity, was noted in embryo-fetal development studies (see section 5.3).
Croatian: Fetotoksičnost, ali ne i teratogenost, primijećena je u ispitivanjima embriofetalnog razvoja (vidjeti dio 5.3).
English: • high blood pressure, paleness, cold extremities
Croatian: • visoki krvni tlak, bljedilo, hladne okrajine
English: Millmount Healthcare Limited, Block 7, City North Business Campus, Stamullen, Co Meath, K32 YD60 Ireland
Croatian: Millmount Healthcare Limited, Block 7, City North Business Campus, Stamullen, Co Meath, K32 YD60 Irska
English: If your doctor thinks that you are having severe side effects, or the effects of Rapiscan are lasting too long, they may give you an injection of a medicine called aminophylline that reduces these effects.
Croatian: Ako Vaš liječnik bude smatrao da imate teške nuspojave, ili da učinci Rapiscana traju predugo, može Vam dati injekciju lijeka zvanog aminofilin koji će smanjiti ove učinke.
English: A relationship between increased severity of disease and the increased incidence of dyspnoea was apparent in patients with asthma, but not in patients with COPD.
Croatian: Odnos između pogoršanja bolesti i porasta incidencije dispneje bila je očita u bolesnika s astmom, ali ne u bolesnika s KOPB.
English: Elevated blood pressure
Croatian: Povišen krvni tlak
English: The risk of significant increases in blood pressure may be higher in patients with uncontrolled hypertension.
Croatian: Rizik od značajnog porasta krvnog tlaka može biti veći u bolesnika s nereguliranom hipertenzijom.
English: Regadenoson does not significantly inhibit the transporters OAT1, OAT3, OCT1, OATP1B1, OATP1B3, MATE1, MATE2-K, BCRP, P-gp, BSEP, ENT 1 or ENT2 at 1 µM.
Croatian: Regadenoson ne inhibira značajno transportere OAT1, OAT3, OCT1, OATP1B1, OATP1B3, MATE1, MATE2-K, BCRP, P-gp, BSEP, ENT 1 ili ENT2 pri 1 µM.
English: Within the dose range of 0.003-0.02 mg/kg (or approximately 0.18-1.2 mg) in healthy subjects, clearance, terminal half-life or volume of distribution do not appear dependent upon the dose.
Croatian: U rasponu doza od 0,003 do 0,02 mg/kg (ili oko 0,18-1,2 mg) u zdravih ispitanika, klirens, terminalni poluvijek ili volumen distribucije čini se da nisu ovisni o dozi.
English: All 1404 patients initially had a baseline MPI scan at rest in accordance with ASNC 2009 guidelines.
Croatian: Kod svih 1404 bolesnika učinjen je početni MPI sken u mirovanju sukladno smjernicama ASNC 2009.
English: The safety and efficacy of regadenoson in children below the age of 18 years have not yet been established.
Croatian: Sigurnost i djelotvornost regadenosona u djece mlađe od 18 godina nisu još ustanovljene.
English: A total of 1,871 of these patients had images considered valid for the primary efficacy evaluation, including 1,294 (69%) men and 577 (31%) women with a median age of 66 years (range 26-93 years of age).
Croatian: Ukupno 1871 od ovih bolesnika imao je slikovne prikaze koji su smatrani važećim za primarnu evaluaciju djelotvornosti, uključujući 1294 (69%) muškaraca i 577 (31%) žena mediane životne dobi od 66 godina (raspon godina 26-93).
English: Rapiscan is injected by a healthcare professional (a doctor, nurse or medical technician) in a medical facility where your heart and blood pressure can be monitored.
Croatian: Rapiscan injiciraju zdravstveni radnici (liječnik, medicinska sestra, medicinski tehničar) u zdravstvenim ustanovama u kojima se može nadzirati rad srca i krvni tlak.