FrancophonIA/ELRC3.0 huggingface dataset:
English: Aptivus should only be used as part of an active combination antiretroviral regimen in patients with no other therapeutic options.
Slovenian: Zdravilo Aptivus lahko uporabljamo samo v sklopu aktivnega protiretrovirusnega režima zdravljenja pri bolnikih, pri katerih ni drugih možnosti zdravljenja.
English: Children Aptivus soft capsules should not be used by children under 12 years of age.
Slovenian: Otroci Aptivus mehke kapsule ne smejo jemati otroci, ki so mlajši od 12 let.
English: Tipranavir adversely interacts with oral contraceptives.
Slovenian: Tipranavir škodljivo medsebojno deluje s peroralnimi kontraceptivi.
English: The safety and efficacy of Aptivus in children under 2 years of age has not been established.
Slovenian: Varnost in učinkovitost zdravila Aptivus pri otrocih, mlajših od 2 let, nista bili dokazani.
English: The net effect will vary depending on the relative affinity of the co-administered substance for CYP3A and P-gp, and the extent of intestinal first-pass metabolism/efflux.
Slovenian: Neto učinek se spreminja glede na relativno afiniteto sočasne snovi za CYP3A in P-gp ter obseg presnove v črevesu med prvim prehodom/efluksom.
English: Higher doses of carbamazepine (> 200 mg) may result in even larger decreases in tipranavir plasma concentrations (see section 4.4).
Slovenian: Večji odmerki karbamazepina (> 200 mg) lahko še močneje zmanjšajo tipranavirjevo koncentracijo v plazmi (glejte poglavje 4.4).
English: H2-receptor antagonists No interaction study performed
Slovenian: Antagonisti receptorjev H2 Raziskave o interakcijah niso izvajali.
English: Until the bottle is exchanged the patient should continue to take the usual doses of the oral solution.
Slovenian: Do zamenjave steklenice naj bolnik nadaljuje z jemanjem običajnih odmerkov peroralne raztopine.
English: In patients less than 12 years of age, however, the oral solution is the only available option for treatment with tipranavir, as no data are available on the efficacy and safety of Aptivus capsules in children less than 12 years of age.
Slovenian: Toda pri mlajših bolnikih od 12 let je zdravljenje s tipranavirjem možno samo s peroralno raztopino, ker o učinkovitosti in varnosti kapsul Aptivus pri mlajših otrocih od 12 let ni podatkov.
English: Increased monitoring (i.e. prior to initiation of therapy, every two weeks during the first three months of treatment, then monthly until 48 weeks, and then every eight to twelve weeks thereafter) is warranted when Aptivus and low dose ritonavir are administered to patients with elevated ASAT and ALAT levels, mild hepatic impairment, chronic hepatitis B or C, or other underlying liver disease.
Slovenian: Zdravljenje je treba pogosteje spremljati (pred začetkom zdravljenja, vsaka dva tedna prve tri mesece zdravljenja, nato vsak mesec do konca 48. tedna, pozneje pa vsakih osem do dvanajst tednov), kadar dajemo zdravilo Aptivus in majhne odmerke ritonavirja bolnikom s povečanima ASAT in ALAT, blago jetrno okvaro, kroničnim hepatitisom B ali C ali drugo jetrno boleznijo.
English: After Week 8, patients in the comparator arm who met the protocol defined criteria of initial lack of virologic response had the option of discontinuing treatment and switching over to tipranavir with ritonavir in a separate roll-over study.
Slovenian: Po 8 tednih so lahko bolniki v primerjalni skupini, ki so izpolnjevali merila v protokolu o začetnem pomanjkanju virološkega odziva, izbirali med ukinitvijo zdravljenja ali prehodom na tipranavir ob ritonavirju v ločenem preskušanju.
English: Tell your child's doctor or pharmacist if your child is taking, has recently taken or might take any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestite otrokovega zdravnika ali farmacevta, če vaš otrok jemlje ali je pred kratkim jemal ali pa bo morda začel jemati katero koli drugo zdravilo, tudi če ga je dobil brez recepta..
English: Treatment response is presented for the overall population (displayed by enfuvirtide use), and detailed by PI strata for the subgroup of patients with genotypically resistant strains in the Table below.
Slovenian: Odziv na zdravljenje je prikazan za vso populacijo (z uporabo enfuvirtida) in podrobno podan s stratumi za zaviralce proteaze za podskupino bolnikov z genotipsko odpornimi sevi v spodnji razpredelnici.
English: In use storage: 60 days (below 25°C) after first opening of the bottle.
Slovenian: Shranjevanje med uporabo: 60 dni (do 25°C) po prvem odprtju steklenice.
English: Doses of ritonavir lower than 150 mg/m 2 twice daily, should not be used as they might alter the efficacy profile of the combination.
Slovenian: Manjših odmerkov ritonavirja od 150 mg/m 2 dvakrat na dan ne smemo uporabljati, ker lahko vplivajo na učinkovitost kombinacije.
English: Aptivus therapy should not be initiated in patients with pre-treatment ASAT or ALAT greater than 5 times the Upper Limit Normal (ULN) until baseline ASAT/ALAT is stabilised at less than 5X ULN, unless the potential benefit justifies the potential risk.
Slovenian: Zdravljenja z zdravilom Aptivus ne uvajamo pri bolnikih, ki katerih sta ASAT ali ALAT pred zdravljenjem večja od 5-kratne zgornje normalne vrednosti, dokler se izhodiščna ASAT ali ALAT ne stabilizira na manj kot 5-kratni zgornji normalni vrednosti, razen kadar možna korist zdravljenja opravičuje možno tveganje.
English: From clinical samples of healthy volunteers and HIV-1 positive subjects who received tipranavir without ritonavir the mean fraction of tipranavir unbound in plasma was similar in both populations (healthy volunteers 0.015%  0.006%; HIV-positive subjects 0.019%  0.076%).
Slovenian: Pri kliničnih vzorcih, pridobljenih pri zdravih prostovoljcih in HIV-1-pozitivnih osebah, ki so prejele tipranavir brez ritonavirja, je bil srednji delež na beljakovine v plazmi nevezanega tipranavirja pri obeh populacijah podoben (zdravi prostovoljci 0,015% ±0,006%; HIV-pozitivne osebe 0,019% ±0,076%).
English: Initiation of treatment should take into account the combinations of mutations which may negatively impact the virological response to Aptivus, coadministered with low dose ritonavir (see section 5.1).
Slovenian: Pri uvajanju zdravljenja je treba upoštevati kombinacije mutacij, ker lahko negativno vplivajo na virološki odziv na zdravilo Aptivus, ki ga dajemo hkrati z majhnimi odmerki ritonavirja (glejte poglavje 5.1).
English: If your child has liver disease or hepatitis, their doctor will decide if they need additional testing.
Slovenian: Če ima vaš otrok jetrno bolezen ali hepatitis, bo njegov zdravnik presodil o potrebi po dodatnih preiskavah.
English: INFORMATION IN BRAILLE Aptivus 250 mg
Slovenian: PODATKI V BRAILLOVI PISAVI Aptivus 250 mg
English: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Slovenian: Pri nekaterih bolnikih z napredovalo okužbo s HIV (aidsom) in oportunističnimi okužbami se lahko kmalu po začetku zdravljenja okužbe s HIV pojavijo znaki in simptomi vnetja, ki so jih povzročale prejšnje okužbe.
English: Tell your doctor if you experience fainting or a sensation of abnormal heart beats.
Slovenian: Zdravniku povejte, če se pojavita omedlevica ali občutek nenormalnega bitja srca.
English: For example the protease inhibitors amprenavir, atazanavir, lopinavir and saquinavir will be decreased.
Slovenian: Zniža se na primer raven zaviralcev proteaze amprenavirja, atazanavirja, lopinavirja in sakvinavirja.
English: A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 (e.g. beclomethasone).
Slovenian: Presoditi je treba o zmanjšanju odmerka glukokortikosteroida in skrbno spremljati lokalne in sistemske učinke ali obstoječi glukokortikosteroid zamenjati s takšnim, ki ni substrat za CYP 3A4 (na primer beklometazonom).
English: Your doctor will only prescribe you abacavir and zidovudine if you are unable to take other NRTIs.
Slovenian: Zdravnik vam bo predpisal abakavir in zidovudin le, če ne boste mogli jemati drugih NRTI.
English: The co-administration of tipranavir with vitamin E in the form of TPGS (d-alphatocopherol polyethylene glycol 1000 succinate) from 2,322 IU/m² upwards in rats resulted in a significant increase in effects on coagulation parameters, bleeding events and death.
Slovenian: Pri sočasnem dajanju tipranavirja in vitamina E v obliki TPGS (d-alfa-tokoferol polietilenglikol 1000 sukcinat) so se od odmerka 2,322 i.e./m2 pri podganah značilno povečali učinki na parametre strjevanja krvi, primeri krvavitev in pogini.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Čeprav je vzrokov verjetno več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo, višjim indeksom telesne mase), so o primerih osteonekroze poročali zlasti pri bolnikih z napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART-combination antiretroviral therapy) ali obojim.
English: Dosing by means of the measuring device remains accurate even when crystals are observed.
Slovenian: Odmerjanje z odmernikom je natančno, četudi so v steklenici kristali.
English: Since tipranavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of this medicine.
Slovenian: Ker se tipranavir v veliki količini veže na beljakovine, ni verjetno, da bi lahko z dializo odstranili pomembnejšo količino zdravila.
English: Based on similarities in the elimination between pravastatin and rosuvastatin, TPV/r could increase the plasma levels of pravastatin.
Slovenian: Glede na podobnosti pri izločanju pravastatina in rosuvastatina bi lahko TPV/r povečal raven pravastatina v plazmi.
English: This difference in concentrations does not warrant a dose adjustment.
Slovenian: Zaradi razlike v koncentraciji odmerka ni treba prilagajati.
English: What you need to know before your child takes Aptivus
Slovenian: Kaj morate vedeti, preden bo vaš otrok vzel zdravilo Aptivus
English: Your doctor may have to increase or decrease the dose of other medicines which you take together with Aptivus.
Slovenian: Zdravnik bo morda povečal ali zmanjšal odmerke drugih zdravil, ki jih jemljete hkrati z zdravilom Aptivus.
English: It is recommended to start with the lowest dose and careful clinical monitoring is necessary (see section 4.4).
Slovenian: Priporočajo najmanjši začetni odmerek in natančno spremljanje zdravljenja (glejte poglavje 4.4).
English: Gently empty Aptivus oral solution from the syringe into your child's mouth.
Slovenian: Narahlo izlijte peroralno raztopino zdravila Aptivus iz brizge v otrokova usta.
English: Fluticasone propionate Interaction study performed only with ritonavir
Slovenian: Flutikazon propionat Raziskavo o interakcijah so izvedli samo z ritonavirjem.
English: Aptivus, co-administered with low dose ritonavir, when combined with warfarin may be associated with changes in INR (International Normalised Ratio) values, and may affect anticoagulation (thrombogenic effect) or increase the risk of bleeding.
Slovenian: Zdravilo Aptivus ob hkratnih majhnih odmerkih ritonavirja lahko pri kombinirani uporabi z varfarinom spremeni vrednost INR (mednarodno umerjeno razmerje) in vpliva na antikoagulacijo (trombogeni učinek) ali poveča nevarnost krvavitve.
English: - Protease Inhibitors (PIs): Taking Aptivus may cause large decreases in the blood levels of other HIV protease inhibitors.
Slovenian: - Zaviralci proteaze (PI): Med jemanjem zdravila Aptivus se lahko močno znižajo ravni drugih zaviralcev proteaze HIV v krvi.
English: Alternate antimycobacterial agents such as rifabutin should be considered.
Slovenian: Presoditi je treba o uporabi alternativniih protimikobakterijskih zdravil, na primer rifabutinu.
English: Treatment response* at week 48 (pooled studies RESIST-1 and RESIST-2 in treatmentexperienced patients)
Slovenian: Odziv za zdravljenje* po 48 tednih (zbrani podatki iz raziskav RESIST-1 in RESIST-2 pri bolnikih, ki so že prejeli več režimov zdravljenja)
English: Your child must not take products containing St John's wort (a herbal remedy for depression).
Slovenian: Vaš otrok ne sme jemati pripravkov, ki vsebujejo šentjanževko (zdravilo rastlinskega izvora za depresijo).
English: Among all randomised and treated patients, the median change from baseline in CD4+ cell count at the last measurement up to Week 48 was +23 cells/mm
Slovenian: Med vsemi naključno izbranimi in zdravljenimi bolniki je bila srednja sprememba števila celic CD4+ glede na izhodiščno vrednost ob zadnji meritvi do 48. tedna +23 celic/mm
English: At the age of 12 years, children treated with Aptivus should be switched from the oral solution to the capsules.
Slovenian: Pri starosti 12 let je treba otrokom, ki se zdravijo z zdravilomAptivus, peroralno raztopino zamenjati za kapsule.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections and pneumocystis pneumonia.
Slovenian: Pomembnejša tovrstna stanja so retinitis s citomegalovirusom, generalizirane ali fokalne mikobakterijske okužbe in pljučnica s pneumocystisom.
English: Since Aptivus capsules and oral solution are not bioequivalent, results obtained with the oral solution cannot be extrapolated to the capsules (see also section 5.2).
Slovenian: Ker kapsule in peroralna raztopina Aptivus nimata enake biološke uporabnosti, izsledkov o peroralni raztopini ne moremo prenesti na kapsule (glejte tudi poglavje 5.2).
English: The unbound fraction of tipranavir appeared to be independent of total concentration over this concentration range.
Slovenian: Kazalo je, da je nevezani delež tipranavirja v tem območju koncentracij neodvisen od skupne koncentracije.
English: In deciding to initiate treatment with Aptivus, co-administered with low dose ritonavir, careful consideration should be given to the treatment history of the individual patient and the patterns of mutations associated with different agents.
Slovenian: Ko se odločamo o uvajanju zdravljenja z zdravilom Aptivus, ob hkratnih majhnih odmerkih ritonavirja, moramo skrbno pregledati podatke o prejšnjem zdravljenju posameznega bolnika in vzorce mutacij, ki so se pojavile pri različnih učinkovinah.
English: Relationships between baseline phenotypic susceptibility to tipranavir, primary PI mutations, protease mutations at codons 33, 82, 84 and 90, tipranavir resistance-associated mutations, and response to tipranavir with ritonavir therapy were assessed.
Slovenian: Ocenili so povezave med izhodiščno fenotipsko občutljivostjo za tipranavir, primarnimi mutacijami PI, mutacijami proteaze na kodonih 33, 82, 84 in 90, mutacijami, povezanimi z odpornostjo proti tipranavirju, in odzivom na zdravljenje s tipranavirjem ob ritonavirju.
English: The interaction profile of Aptivus, co-administered with low dose ritonavir, is complex and requires special attention in particular in combination with other antiretroviral agents.
Slovenian: Profil medsebojnega delovanja zdravila Aptivus, ob hkratnih majhnih odmerkih ritonavirja, je kompleksen, zato moramo biti posebno pozorni, zlasti pri kombinaciji z drugimi protiretrovirusnimi zdravili.
English: Turn the bottle upside down and gently withdraw the required amount of Aptivus oral solution.
Slovenian: Steklenico obrnite navzdol in narahlo odvzemite potrebno količino peroralne raztopine Aptivus.
English: In the case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
Slovenian: Če bolnik sočasno prejema protivirusna zdravila zaradi hepatitisa B ali C, je treba pregledati tudi Povzetke glavnih značilnosti teh zdravil.
English: HIV-positive, paediatric patients, aged 2 through 18 years, were studied in a randomized, open-label, multicenter study (trial 1182.14).
Slovenian: HIV pozitivne otroke, stare 2 do 18 let, so proučevali v odprti multicentrični raziskavi z naključno izbiro (raziskava 1182.14).
English: Tell your doctor if you receive medicines such as blood-thinning agents, or if you are taking vitamin E. Your doctor may wish to consider certain precautionary measures in such circumstances.
Slovenian: Obvestite svojega zdravnika, če prejemate zdravila, kot so zdravila za redčenje krvi ali jemljete vitamin E. Zdravnik bo v tem primeru presodil ali so potrebni določeni previdnostni ukrepi.
English: Other HMG-CoA reductase inhibitors should be considered such as pravastatin, fluvastatin or rosuvastatin (See also section 4.4 and rosuvastatin and pravastatin recommendations).
Slovenian: Presoditi je treba o drugih zaviralcih HMG CoA reduktaze, na primer pravastatinu, fluvastatinu ali rosuvastatinu (glejte tudi poglavje 4.4 ter priporočila za rosuvastatin in pravastatin).
English: Your child must NOT stop taking Aptivus unless your child's doctor instructs to do so.
Slovenian: Vaš otrok NE sme prenehati jemati zdravila Aptivus, razen, če mu tako naroči otrokov zdravnik.
English: Excipients with known effect: Each soft capsule contains 100.0 mg ethanol, 455.0 mg macrogolglycerol ricinoleate and 12.6 mg sorbitol For the full list of excipients, see section 6.1.
Slovenian: Pomožne snovi z znanim učinkom: ena mehka kapsula vsebuje 100,0 mg etanola, 455,0 mg makrogolglicerol ricinolata in 12,6 mg sorbitola.
English: Therefore, it is recommended that patients switching from Aptivus oral solution to capsules at the age of 12 years are closely monitored for the virologic response of their antiretroviral regimen (see sections 5.1 and 5.2).
Slovenian: Zato je po prehodu z zdravila Aptivus peroralna raztopina na kapsule pri starosti 12 let priporočeno natančno spremljanje virološkega odziva na protiretrovirusni režim (glejte poglavji 5.1 in 5.2).
English: Tipranavir maintains significant antiviral activity (< 4-fold resistance) against the majority of HIV-1 clinical isolates showing post-treatment decreased susceptibility to the currently approved protease inhibitors: amprenavir, atazanavir, indinavir, lopinavir, ritonavir, nelfinavir and saquinavir.
Slovenian: Tipranavir ohrani znatno protivirusno delovanje (< 4-kratno odpornost) proti večini kliničnih izolatov HIV-1, katerih občutljivost za doslej odobrene zaviralce proteaze se po zdravljenju zmanjša, in sicer za amprenavir, atazanavir, indinavir, lopinavir, ritonavir, nelfinavir in sakinavir.
English: C-tipranavir with 200 mg ritonavir, twice daily), unchanged tipranavir was predominant and accounted for 98.4% or greater of the total plasma radioactivity circulating at 3, 8, or 12 hours after dosing.
Slovenian: C-tipranavirja ob 200 mg ritonavirja, dvakrat na dan) je prevladoval nespremenjeni tipranavir, ki je sestavljal 98,4% ali več skupne radioaktivnosti v plazmi 3, 8 ali 12 ur po vnosu.
English: Colchicine is a substrate of CYP3A4 and P-gp (an intestinal efflux transporter).
Slovenian: Kolhicin je substrat za CYP3A4 in P-gp (efluksni prenašalec v črevesu)
English: These have generally occurred in patients with advanced HIV disease taking multiple concomitant medicinal products.
Slovenian: Večinoma so jih zasledili pri bolnikih z napredovalo okužbo s HIV, ki so hkrati jemali več drugih zdravil.
English: In a study comparing 9 patients with mild (Child-Pugh A) hepatic impairment to 9 controls, the single and multiple dose exposure of tipranavir and ritonavir were increased in patients with hepatic impairment but still within the range observed in clinical studies.
Slovenian: V raziskavi, v kateri so primerjali 9 bolnikov z blago (stopnje A po Child-Pughovi razvrstitvi) jetrno okvaro z 9 kontrolnimi bolniki, se je farmakokinetična dispozicija tipranavirja in ritonavirja pri bolnikih z jetrno okvaro povečala, toda ostala znotraj območja, o katerem so poročali v kliničnih študijah.
English: The clinical relevance of this reduction has not been established, but may decrease the efficacy of abacavir.
Slovenian: Klinični pomen tega zmanjšanja ni znan, lahko pa zmanjša abakavirjevo učinkovitost.
English: Inhaled beta agonists Salmeterol
Slovenian: Inhalacijski agonisti adrenergičnih receptorjev beta Salmeterol
English: Tell your child's doctor if your child experiences fainting or a sensation of abnormal heart beats.
Slovenian: Zdravniku vašega otroka povejte, če se pri vašem otroku pojavita omedlevica ali občutek nenormalnega bitja srca.
English: Therefore, routine measurement of coagulation parameters is not currently indicated in the management of patients on Aptivus.
Slovenian: Zato med zdravljenjem z zdravilom Aptivus rutinske meritve koagulacijskih parametrov zaenkrat niso indicirane.
English: emtricitabine: If your child is taking emtricitabine your child's kidney function should be checked before initiation of Aptivus.
Slovenian: - Emtricitabin: Če vaš otrok jemlje emtricitabin, je treba vašemu otroku opraviti preiskavo ledvičnega delovanja, preden bo začel jemati zdravilo Aptivus.
English: It is advisable that the patient writes the date of opening the bottle on the label and/or carton.
Slovenian: Priporočljivo je, da bolnik na nalepko ali škatlo ali obe napiše datum, ko je steklenico odprl.
English: If you notice any of these symptoms please inform your child's doctor.
Slovenian: Če opazite katerega od teh simptomov, morate obvestiti otrokovega zdravnika.
English: If your child has haemophilia type A and B, they may experience increased bleeding.
Slovenian: Če ima vaš otrok hemofilijo tipa A in B, se lahko pri njemu povečajo krvavitve.
English: Tipranavir is a substrate, an inducer and an inhibitor of cytochrome P450 CYP3A.
Slovenian: Tipranavir je substrat, induktor in zaviralec citokroma P450 CYP3A.
English: Carcinogenicity studies of tipranavir in mice and rats revealed tumourigenic potential specific for these species, which are regarded as of no clinical relevance.
Slovenian: Raziskave o kancerogenosti tipranavirja so pri miših in podganah odkrile za obe živalski vrsti specifično tumorogeno delovanje, ki pa velja za klinično nepomembno.
English: Increasing baseline phenotypic fold change to tipranavir in isolates is correlated to decreasing virological response.
Slovenian: Naraščajoča izhodiščna fenotipska stopnja razlike občutljivosti na tipranavir v izolatih je v korelaciji z upadanjem virološkega odziva.
English: The effective mean elimination half-life of tipranavir with ritonavir in healthy volunteers (n = 67) and HIV-infected adult patients (n = 120) was approximately 4.8 and 6.0 hours, respectively, at steady state following a dose of 500 mg/200 mg twice daily with a light meal.
Slovenian: Efektivna srednja razpolovna doba izločanja tipranavirja ob ritonavirju pri zdravih prostovoljcih (n = 67) in s HIV okuženih odraslih (n = 120) je bila približno 4,8 in 6,0 ure, v ravnovesnem stanju po dajanju odmerkov po 500 mg/200 mg dvakrat na dan, 1 dan, z lahkim obrokom hrane.
English: The mean steady-state trough concentration prior to the morning dose was 41.6 ± 24.3 µM for female patients and 35.6 ± 16.7 µM for male patients.
Slovenian: Srednja koncentracija v ravnovesnem stanju ob pojemanju učinka pred jutranjim odmerkom je bila 41,6  24,3 µM pri ženskah in 35,6  16,7 µM pri moških.
English: A small amount of crystals may be observed in the bottle, which does not affect the potency or safety of the product.
Slovenian: Majhna količina kristalov v steklenici ne zmanjša učinkovitosti ali varnosti zdravila.
English: Rash accompanied by joint pain or stiffness, throat tightness, or generalized pruritus has been reported in both men and women receiving Aptivus co-administered with low dose ritonavir.
Slovenian: O izpuščaju, ki sta ga spremljala bolečina ali togost sklepa, stiskanje v grlu ali generaliziran pruritus, so poročali pri moških in ženskah, ki so prejemali zdravilo Aptivus ob hkratnih majhnih odmerkih ritonavirja.