FrancophonIA/ELRC3.0 huggingface dataset:
English: The full European Public Assessment Report for Avastin can be found on the Agency's website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Slovenian: Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Avastin je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: The main measures of effectiveness were overall survival (how long the patients lived) and progression-free survival (how long the patients lived without their disease getting worse).
Slovenian: Glavno merilo učinkovitosti je bilo skupno preživetje (koliko časa so bolniki živeli) in preživetje brez napredovanja bolezni (čas, ki so ga bolniki preživeli brez poslabšanja bolezni).
English: Refusal of a change to the marketing authorisation for Avastin (bevacizumab) EMA/577647/2014
Slovenian: Zavrnitev vloge za spremembo dovoljenja za promet z zdravilom Avastin (bevacizumab) EMA/577647/2014
English: Although there was an improvement in progression-free survival, it could not be considered clinically relevant because of limitations in the methods available to measure the size of brain tumours.
Slovenian: Čeprav je prišlo do izboljšanja preživetja brez napredovanja bolezni, tega ni bilo mogoče šteti za klinično pomembno zaradi pomanjkljivosti metod, ki so bile na voljo za merjenje velikosti možganskih tumorjev.
English: The company presented the results from one main study with Avastin involving 921 patients with newly diagnosed glioblastoma.
Slovenian: Družba je predložila rezultate ene glavne študije z zdravilom Avastin, ki je vključevala 921 bolnikov z novo postavljeno diagnozo glioblastoma.
English: There are no consequences on the use of Avastin in its authorised indications.
Slovenian: Zavrnitev nima nobenih posledic za uporabo zdravila Avastin pri odobrenih indikacijah.
English: At the time of the initial recommendation the CHMP noted that the effectiveness of Avastin in combination with radiotherapy and temozolomide had not been sufficiently demonstrated.
Slovenian: V času prvotnega priporočila je odbor CHMP zabeležil, da učinkovitost zdravila Avastin v kombinaciji z radioterapijo in temozolomidom ni bila zadostno dokazana.
English: The change concerned an extension of indication to add treatment of glioblastoma (an aggressive type of brain cancer).
Slovenian: Sprememba se je nanašala na razširitev indikacije, tako da bi se zdravilo uporabljalo tudi za zdravljenje glioblastoma (vrste agresivnega raka na možganih).
English: It is used, in combination with other chemotherapy medicines (medicines to treat cancer), to treat certain types of the following cancers: cancer of the colon or rectum (large intestine); breast cancer; lung cancer; kidney cancer; cancer of the ovary; cancer of the fallopian tube or the peritoneum (the membrane lining the abdomen).
Slovenian: Uporablja se v kombinaciji z drugimi kemoterapevtiki (zdravili za zdravljenje raka) za zdravljenje določenih vrst rakov, in sicer: raka kolona ali rektuma (debelega črevesa), raka dojke, pljučnega raka, raka ledvic, raka jajčnikov, raka jajcevodov ali potrebušnice (trebušne mrene).
English: It is available as a concentrate that is made up into a solution for infusion (drip into a vein).
Slovenian: Na voljo je kot koncentrat za pripravo raztopine za infundiranje (kapalne infuzije v veno).
English: What is Avastin?
Slovenian: Kaj je zdravilo Avastin?
English: On 22 May 2014, the Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion, recommending the refusal of a change to the marketing authorisation for the medicinal product Avastin.
Slovenian: Odbor za zdravila za uporabo v humani medicini (CHMP) je 22. maja 2014 sprejel negativno mnenje in priporočil zavrnitev vloge za spremembo dovoljenja za promet z zdravilom Avastin.
English: After considering the grounds for this request, the CHMP re-examined the initial opinion, and confirmed the refusal of the marketing authorisation on 22 September 2014.
Slovenian: Po preučitvi podlage za to zahtevo je odbor CHMP ponovno pregledal prvotno mnenje in 22. septembra 2014 potrdil zavrnitev vloge za spremembo dovoljenja za promet z zdravilom.
English: During the re-examination, the CHMP looked again at the data from the company and confirmed its opinion that the benefits of Avastin had not been sufficiently demonstrated in newly diagnosed glioblastoma.
Slovenian: Pri ponovnem pregledu je odbor CHMP znova pregledal podatke, ki jih je predložila družba, in potrdil svoje mnenje, da koristi zdravila Avastin niso bile zadostno dokazane pri novo postavljeni diagnozi glioblastoma.
English: Refusal of a change to the marketing authorisation for Avastin (bevacizumab)
Slovenian: Zavrnitev vloge za spremembo dovoljenja za promet z zdravilom Avastin (bevacizumab)
English: The active substance in Avastin, bevacizumab, is a monoclonal antibody (a type of protein), that has been designed to recognise and attach to vascular endothelial growth factor (VEGF), a protein that
Slovenian: Zdravilna učinkovina v zdravilu Avastin, bevacizumab, je monoklonsko protitelo (vrsta beljakovine), ki deluje tako, da prepozna žilni endotelijski rastni faktor (VEGF), tj. beljakovino, ki kroži v krvi in
English: What is happening with Avastin for treatment of other cancers?
Slovenian: Kakšne so posledice za zdravilo Avastin, indicirano za zdravljenje drugih vrst raka?
English: Avastin is a cancer medicine that contains the active substance bevacizumab.
Slovenian: Avastin je zdravilo za zdravljenje raka, ki vsebuje zdravilno učinkovino bevacizumab.
English: By attaching to VEGF, Avastin stops cancer cells from developing their own blood supply and starves them of oxygen and nutrients, helping to slow down the growth of the cancer.
Slovenian: Zdravilo Avastin tako z vezanjem na ta faktor povzroči, da se rakave celice ne morejo oskrbovati s krvjo in dobivajo premalo kisika ter hranil, kar pripomore k upočasnitvi rasti raka.
English: What were the CHMP's main concerns that led to the refusal of the change to the marketing authorisation?
Slovenian: Kateri so bili glavni zadržki, zaradi katerih je odbor CHMP predlagal zavrnitev vloge za spremembo dovoljenja za promet z zdravilom?
English: Avastin was also expected to be used to treat adult patients with newly diagnosed glioblastoma in combination with radiotherapy (treatment with radiation) and temozolomide (another cancer medicine).
Slovenian: Zdravilo Avastin naj bi se prav tako uporabljalo v kombinaciji z radioterapijo (zdravljenjem z obsevanjem) in temozolomidom (drugim zdravilom za zdravljenje raka) za zdravljenje odraslih bolnikov z novo postavljeno diagnozo glioblastoma.
English: What was Avastin expected to be used for?
Slovenian: Za kaj naj bi se zdravilo Avastin uporabljalo?
English: In the study, patients received Avastin or placebo (a dummy treatment) in addition to treatment with radiotherapy and temozolomide.
Slovenian: V študiji so bolniki poleg zdravljenja z radioterapijo in temozolomidom prejemali zdravilo Avastin ali placebo (zdravilo brez zdravilne učinkovine).
English: circulates in the blood and makes blood vessels grow.
Slovenian: povzroča rast krvnih žil, in se veže nanj.
English: How is Avastin expected to work?
Slovenian: Kako naj bi zdravilo Avastin delovalo?
English: The company informed the CHMP that there are no consequences for patients with glioblastoma receiving Avastin in clinical trials: patients will continue to receive Avastin in the on-going and future clinical trials.
Slovenian: Družba je obvestila odbor CHMP, da zavrnitev nima nobenih posledic za bolnike z glioblastomom, ki prejemajo zdravilo Avastin v kliničnih preskušanjih.
English: Therefore, the CHMP maintained its previous recommendation that the change to the marketing authorisation be refused.
Slovenian: Zato je ostal pri svojem prejšnjem priporočilu, da zavrne vlogo za spremembo dovoljenja za promet z zdravilom.
English: Therefore, at that point in time, the CHMP was of the opinion that the benefits of Avastin in the treatment of newly diagnosed glioblastoma did not outweigh its risks.
Slovenian: Posledično je odbor CHMP tedaj menil, da koristi zdravila Avastin pri zdravljenju novo postavljene diagnoze glioblastoma ne odtehtajo z njim povezanih tveganj, zato je priporočil zavrnitev vloge za spremembo dovoljenja za promet z zdravilom.
English: --1 Porcine circovirus type 2 ORF2 subunit antigen ≥4.5 log2 ELISA units* * Antibody titre obtained according to the in vivo potency test in chickens
Slovenian: --1 Cirkovirus prašičev, tip 2, antigenska podenota ORF2: ≥ 4,5 log2 enot ELISA* * Titer protiteles je določen z in vivo preskusom učinkovitosti pri piščancih.
English: MA (EU) number
Slovenian: MA (EU) številka
English: Packaging Content Package size
Slovenian: Velikost pakiranj a
English: Many may feel quite normal.
Slovenian: Veliko se jih lahko po uti povsem normalno.
English: “Recent” here means between 12 hours and 10 days.
Slovenian: "Nedavni" pri tem pomeni pred 12 urami do 10 dnevi.
English: • Medicines should not be disposed of via wastewater or household waste.
Slovenian: • Zdravila ne smete odvre i v odpadne vode ali med gospodinjske odpadke.
English: Take Diovan at about the same time each day.
Slovenian: Zdravilo Diovan vzemite vsak dan ob približno istem asu.
English: The average accumulation factor is about 1.7.
Slovenian: Povpre ni akumulacijski faktor je okrog 1,7.
English: It may harm them, even if their symptoms are the same as yours.
Slovenian: Njim bi lahko celo škodovalo, eprav imajo znake bolezni, podobne vašim.
English: People with high blood pressure often do not notice any signs of this problem.
Slovenian: Ljudje z visokim krvnim tlakom pogosto ne utijo nobenih težav, povezanih s tem.
English: • lithium, a medicine used to treat some types of psychiatric illness.
Slovenian: • litij, zdravilo za zdravljenje nekaterih vrst psihiatri nih bolezni.
English: Member State EU/EEA
Slovenian: EU/EGP
English: Do not stop taking your medicine unless your doctor tells you to.
Slovenian: Ne prenehajte jemati zdravila, razen e vam je tako naro il zdravnik.
English: Kemistvägen 1B P.O.
Slovenian: Kemistvägen 1B P.O. Box 1150
English: It is caused when the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body.
Slovenian: Do tega pride takrat, ko sr na rpalka ne more rpati dovolj krvi, da bi s krvjo oskrbela celotno telo.
English: Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestite svojega zdravnika ali farmacevta, e jemljete ali ste pred kratkim jemali katerokoli zdravilo, tudi e ste ga dobili brez recepta.
English: The half-life of valsartan is 6 hours.
Slovenian: Razpolovni as valsartana je približno 6 ur.
English: • Submit a Risk Management Plan (or its update) for Diovan at National level, taking into account the new paediatric data and the CHMP recommendations.
Slovenian: • predložil na rt za obvladovanje tveganja (ali njegovo posodobitev) za zdravilo Diovan na nacionalni ravni ob upoštevanju novih pediatri nih podatkov in priporo il CHMP.
English: Valsartan shows multiexponential decay kinetics (t½ <1 h and t½ß about 9 h).
Slovenian: Valsartan kaže multieksponentno kinetiko upadanja (t½ <1 ura in t½ß približno 9 ur).
English: Lowering your blood pressure to normal reduces the risk of developing these disorders.
Slovenian: Z znižanjem krvnega tlaka na normalne vrednosti, se zmanjša tveganje za razvoj teh bolezni.
English: The mean treatment duration was two years.
Slovenian: Zdravljenje je trajalo povpre no dve leti.
English: This period coincides with 36 weeks of gestation in humans, which could occasionally extend up to 44 weeks after conception in humans.
Slovenian: To obdobje se ujema s 36 tedni nose nosti pri ljudeh, kar bi v asih lahko podaljšali tudi do 44. tedna po spo etju pri ljudeh.
English: • difficulty in breathing or swallowing
Slovenian: • težave z dihanjem ali s požiranjem
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORMS, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTE OF ADMINISTRATION AND MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
Slovenian: DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH LANICAH
English: Valsartan is highly bound to serum proteins (94-97%), mainly serum albumin.
Slovenian: Valsartan je mo no vezan na beljakovine v serumu (94-97 %), predvsem na albumin v serumu.
English: Like many other medicines used to treat high blood pressure, Diovan may in rare cases cause dizziness and affect the ability to concentrate.
Slovenian: Kot številna druga zdravila za zdravljenje visokega krvnega tlaka lahko zdravilo Diovan v redkih primerih povzro i omoti nost in vpliva na sposobnost koncentracije.
English: Stopping your treatment with Diovan may cause your disease to get worse.
Slovenian: Prenehanje zdravljenja z zdravilom Diovan lahko povzro i poslabšanje vaše bolezni.
English: Valsartan is not known to bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Slovenian: Ni znano, da bi valsartan vezal ali zaviral druge receptorje hormonov ali ionske kanal ke, ki so pomembni za kardiovaskularno regulacijo.
English: When driving vehicles or operating machines it should be taken into account that occasionally dizziness or weariness may occur.
Slovenian: Pri vožnji ali upravljanju s stroji je treba upoštevati, da se lahko ob asno pojavi omoti nost ali ob utek utrujenosti.
English: The protocol of the study will be submitted by the applicant in the second quarter of 2010 for agreement with the CHMP with input from the PDCO.
Slovenian: Protokol študije bo predlagatelj predložil v drugem etrtletju leta 2010 za pridobitev soglasja odbora CHMP ob upoštevanju mnenja Odbora za pediatrijo (PDCO).
English: Overall, the dosedependent antihypertensive effect of valsartan was consistent across all the demographic subgroups.
Slovenian: V celoti je bilo od odmerka odvisno antihipertenzivno delovanje valsartana skladno po vseh demografskih podskupinah.
English: Overdose with Diovan may result in marked hypotension, which could lead to depressed level of consciousness, circulatory collapse and/or shock.
Slovenian: Preveliko odmerjanje zdravila Diovan lahko povzro i izrazito hipotenzijo, ki lahko vodi v motnje zavesti, cirkulacijski kolaps in/ali šok.
English: These side effects may occur with certain frequencies, which are defined as follows: very common: affects more than 1 user in 10 common: affects 1 to 10 users in 100 uncommon: affects 1 to 10 users in 1,000 rare: affects 1 to 10 users in 10,000 very rare: affects less than 1 user in 10,000 not known: frequency cannot be estimated from the available data.
Slovenian: Neželeni u inki se pojavljajo s pogostnostjo, ki je opredeljena spodaj: zelo pogosti: prizadenejo ve kot 1 od 10 uporabnikov pogosti: prizadenejo 1 do 10 od 100 uporabnikov ob asni: prizadenejo 1 do 10 od 1.000 uporabnikov redki: prizadenejo 1 do 10 od 10.000 uporabnikov zelo redki: prizadenejo manj kot 1 od 10.000 uporabnikov neznana: pogostnosti ni mogo e oceniti iz razpoložljivih podatkov
English: Before you drive a vehicle, use tools or operate machines, or carry out other activities that require concentration, make sure you know how Diovan affects you.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Preden za nete voziti, uporabljati orodje, upravljati stroje ali izvajati druge dejavnosti, ki zahtevajo zbranost, morate zagotovo vedeti, kako zdravilo Diovan deluje na vas.
English: Side effects in children and adolescents are similar to those seen in adults.
Slovenian: Pri otrocih in mladostnikih so neželeni u inki podobni kot pri odraslih.
English: • if you are allergic (hypersensitive) to valsartan or any of the other ingredients of Diovan listed at the end of this leaflet.
Slovenian: • e ste alergi ni (preob utljivi) na valsartan ali katerekoli sestavine zdravila Diovan, ki so navedene na koncu tega navodila,
English: • if you suffer from aldosteronism.
Slovenian: • e imate aldosteronizem.
English: Valsartan does not exhibit any partial agonist activity at the AT1 receptor and has much (about 20,000 fold) greater affinity for the AT1 receptor than for the AT2 receptor.
Slovenian: Valsartan nima delnega agonisti nega u inka na receptorje AT1 in ima veliko (približno 20.000-kratno) ve jo afiniteto za receptorje AT1 kot za receptorje AT2.
English: All changes were considered to be caused by the pharmacological action of valsartan which produces prolonged hypotension, particularly in marmosets.
Slovenian: Vse spremembe so pripisali farmakološkemu u inku valsartana, ki povzro a podaljšano hipotenzijo, še zlasti pri marmozetkah.
English: • Do not use Diovan if you notice that the pack is damaged or shows signs of tampering.
Slovenian: • Ne uporabljajte zdravila Diovan, e opazite, da je ovojnina poškodovana ali opazite, da je bila že odprta.
English: If any of these apply to you, tell your doctor before you take Diovan.
Slovenian: e karkoli od naštetega velja za vas, obvestite svojega zdravnika, preden uporabite zdravilo Diovan.
English: The addition of a diuretic such as hydrochlorothiazide will decrease blood pressure even further in these patients.
Slovenian: Dodajanje diuretika, kot je hidroklorotiazid, pri teh bolnikih še bolj zniža krvni tlak.
English: This is a disease in which your adrenal glands make too much of the hormone aldosterone.
Slovenian: To je bolezen, pri kateri vaše nadledvi ne žleze tvorijo preve hormona aldosterona.
English: If you forget to take a dose, take it as soon as you remember.
Slovenian: e ste pozabili vzeti zdravilo Diovan e pozabite vzeti odmerek, ga vzemite takoj, ko se spomnite.
English: It may be necessary to check the amount of potassium in your blood at regular intervals.
Slovenian: Morda bo treba v rednih intervalih preverjati koli ino kalija v vaši krvi,
English: Taking Diovan with food and drink You can take Diovan with or without food.
Slovenian: Jemanje zdravila Diovan skupaj s hrano in pijao Zdravilo Diovan je mogoe jemati s hrano ali brez nje.
English: If hypotension occurs, the patient should be placed in a supine position and blood volume correction should be undertaken.
Slovenian: e pride do hipotenzije, je treba bolnika položiti vznak in ustrezno popraviti volumen krvi.
English: This medicinal product is authorised in the Member States of the EEA under the following names: [To be completed nationally]
Slovenian: Zdravilo je v državah lanicah EGP pridobilo dovoljenje za promet z naslednjimi imeni: [Izpolni država lanica]
English: Angiotensin II is a substance in the body that causes vessels to tighten, thus causing your blood pressure to increase.
Slovenian: Angiotenzin II je snov v telesu, ki povzro i, da se krvne žile stisnejo, kar povzro i zvišanje krvnega tlaka.
English: Adverse reactions are ranked by frequency, the most frequent first, using the following convention: very common ( 1/10); common ( 1/100 to <1/10); uncommon ( 1/1,000 to <1/100); rare ( 1/10,000 to <1/1,000) very rare (<1/10,000), including isolated reports.
Slovenian: V razvrstitvah pogostnosti so neželeni u inki navedeni po pogostnosti, najbolj pogosti najprej, in sicer po naslednjem dogovoru: zelo pogosti ( 1/10); pogosti ( 1/100 do < 1/10); ob asni ( 1/1.000 do < 1/100); redki ( 1/10.000 do < 1/1.000); zelo redki (<1/10.000), vklju no s posami nimi poro ili.
English: 4.8 Undesirable effects
Slovenian: 4.8 Neželeni u inki
English: • muscle pain (myalgia)
Slovenian: • bole ine v mišicah (mialgija)
English: [To be completed nationally]
Slovenian: [Izpolni država lanica]
English: What Diovan looks like and contents of the pack [To be completed nationally]
Slovenian: Izgled zdravila Diovan in vsebina pakiranja [Izpolni država lanica]
English: Swallow Diovan with a glass of water.
Slovenian: Tablete zdravila Diovan vzemite s kozarcem vode
English: If symptomatic hypotension or renal dysfunction occur, consideration should be given to a dose reduction.
Slovenian: e pride do simptomatske hipotenzije ali ledvi ne disfunkcije, je treba razmisliti o zmanjšanju odmerka.
English: It acts selectively on the AT1 receptor subtype, which is responsible for the known actions of angiotensin II.
Slovenian: Deluje selektivno na receptorje podvrste AT1, ki so odgovorni za znane u inke angiotenzina II.
English: The therapeutic measures depend on the time of ingestion and the type and severity of the symptoms; stabilisation of the circulatory condition is of prime importance.
Slovenian: Ukrepi zdravljenja so odvisni od asa zaužitja in vrste ter izraženosti simptomov; pri tem je najbolj pomembno stabilizirati stanje krvnega obtoka.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION
Slovenian: KAKOVOSTNA IN KOLI INSKA SESTAVA
English: Valsartan is not biotransformed to a high extent as only about 20% of dose is recovered as metabolites.
Slovenian: Valsartan se biološko ne transformira v veliki meri, saj je le približno 20 % odmerka mogo e prestre i v obliki metabolitov.
English: Approximately 70% of the dose absorbed is eliminated in the bile, essentially in the unchanged form.
Slovenian: Okrog 70 % absorbiranega odmerka se izlo i z žol em, ve inoma v obliki nespremenjene spojine.
English: Combining valsartan with captopril did not add further benefit over captopril alone.
Slovenian: Kombinacija valsartana s kaptoprilom ni prinesla dodatnih koristi v primerjavi z uporabo le kaptoprila.
English: Elderly No dose adjustment is required in elderly patients.
Slovenian: Starejši bolniki Pri starejših bolnikih ni treba prilagajati odmerka.
English: In drug interaction studies with valsartan, no interactions of clinical significance have been found with valsartan or any of the following substances: cimetidine, warfarin, furosemide, digoxin, atenolol, indometacin, hydrochlorothiazide, amlodipine, glibenclamide.
Slovenian: Pri študijah medsebojnega delovanja zdravil z valsartanom niso opazili klini no pomembnih interakcij z valsartanom ali katero koli od naslednjih u inkovin: cimetidin, varfarin, furosemid, digoksin, atenolol, indometacin, hidroklorotiazid, amlodipin in glibenklamid.
English: • to treat adult patients after a recent heart attack (myocardial infarction).
Slovenian: • Za zdravljenje odraslih bolnikov po nedavnem sr nem infarktu (miokardni infarkt).
English: Do not take a double dose to make up for a forgotten dose.
Slovenian: Ne vzemite dvojnega odmerka, e ste pozabili vzeti prejšnji odmerek.
English: The safety profile seen in controlled-clinical studies in adult patients with post-myocardial infarction and/or heart failure varies from the overall safety profile seen in hypertensive patients.
Slovenian: Varnostni profil iz kontroliranih klini nih študij pri odraslih bolnikih po miokardnem infarktu in/ali s sr nim popuš anjem se razlikuje od splošnega profila varnosti pri hipertenzivnih bolnikih.
English: As expected for a compound where renal clearance accounts for only 30% of total plasma clearance, no correlation was seen between renal function and systemic exposure to valsartan.
Slovenian: V skladu s pri akovanji za spojino, katere ledvi ni o istek predstavlja samo 30 % celotnega o istka plazme, niso našli nikakršne korelacije med delovanjem ledvic in sistemsko izpostavljenostjo valsartanu.
English: Laboratório Normal-Produtos Farmacêuticos, Lda Rua do Centro Empresarial, Edificio 8 Quinta da Beloura
Slovenian: Laboratório Normal-Produtos Farmacêuticos, Lda Rua do Centro Empresarial,
English: • [Storage conditions statements - To be completed nationally]
Slovenian: • [Pogoji shranjevanja - izpolni država lanica]
English: • if you have recently undergone kidney transplantation (received a new kidney).
Slovenian: • e so vam pred kratkim presadili ledvico (dobili ste novo ledvico),
English: The steady-state volume of distribution of valsartan after intravenous administration is about 17 litres, indicating that valsartan does not distribute into tissues extensively.
Slovenian: Volumen porazdelitve valsartana v stanju dinami nega ravnovesja je po intravenskem vnosu okrog 17 litrov, kar kaže, da se valsartan v tkiva ne porazdeli v veliki meri.