FrancophonIA/ELRC3.0 huggingface dataset:
English: In a Canadian study, of the 12 assessable patients (out of 15), 10 showed a reduction in urinary free cortisol levels, but only five had complete resolution on ketoconazole doses 400 to 1200 mg/day.
Slovenian: V kanadski študiji so od 12 za oceno primernih bolnikov (od 15) pri 10 bolnikih zaznali znižanje ravni prostega kortizola v urinu, vendar je samo pri petih prišlo do popolne normalizacije z uporabo odmerkov ketokonazola od 400 do 1200 mg/dan.
English: Patients treated with a block-and-replace regimen should be taught to adjust their glucocorticoid replacement therapy dose under conditions of stress (see section 4.2).
Slovenian: Bolnike, ki se zdravijo z režimom zaviranja in nadomeščanja, je treba naučiti, kako prilagajati odmerek nadomestnega zdravljenja z glukokortikoidi, kadar so pod stresom (glejte poglavje 4.2).
English: Ketoconazole is contraindicated during pregnancy and it should not be used in women of childbearing potential not using an effective method of contraception (see section 4.3).
Slovenian: Ketokonazol je kontraindiciran med nosečnostjo in se ne sme uporabljati pri ženskah v rodni dobi, ki ne uporabljajo učinkovite kontracepcijske metode (glejte poglavje 4.3).
English: Co-administration of ketoconazole and other medicinal products known to have potentially hepatotoxic effect (eg paracetamol) is not recommended since the combination may lead to increased risk of liver damage.
Slovenian: Sočasna uporaba ketokonazola in drugih zdravil, za katere je znano, da imajo morebitni hepatotoksični učinek (npr. paracetamol), ni priporočljiva, saj lahko ta kombinacija povzroči povečano tveganje jetrne poškodbe.
English: Although data are limited, the pharmacokinetics of ketoconazole are not significantly different in patients with renal failure compared to healthy subjects, and no specific dose adjustment is recommended in this population.
Slovenian: Čeprav so podatki omejeni, se farmakokinetika ketokonazola znatno ne razlikuje med bolniki z ledvično odpovedjo in zdravimi preizkušanci, zato se pri tej populaciji ne priporoča posebno prilagajanje odmerka.
English: Warfarin and other coumarin-like drugs
Slovenian: Varfarin in druga kumarinu podobna zdravila
English: More than 800 patients have been treated with ketoconazole with variable treatment duration and modalities.
Slovenian: S ketokonazolom so zdravili več kot 800 bolnikov, pri čemer sta bila trajanje in način zdravljenja različna.
English: Cushing's syndrome is caused by overproduction of a hormone called cortisol which is produced by the adrenal glands.
Slovenian: Cushingov sindrom povzroča čezmerna tvorba hormona, imenovanega kortizol, ki ga proizvaja nadledvična žleza.
English: Electrophysiological studies have shown that ketoconazole inhibits the rapidly activating component of the cardiac delayed rectifier potassium current, prolongs the action potential duration, and may prolong the QT interval.
Slovenian: Elektrofiziološke študije so pokazale, da ketokonazol zavira hitro aktivacijsko komponento srčnega zapoznelega toka usmerjevalnih kalijevih kanalčkov, podaljša potencial delovanja in lahko podaljša interval QT.
English: Treatment with ketoconazole in paediatric patients allowed normalisation of urinary free cortisol levels and clinical improvement, including recovering of growth rate and gonadal function, normalisation of blood pressure, Cushing's syndrome features and weight loss in most of the cases.
Slovenian: Zdravljenje pediatričnih bolnikov s ketokonazolom je pri večini omogočilo normalizacijo ravni prostega kortizola v urinu in klinično izboljšanje, vključno z izboljšanjem hitrosti rasti in delovanja spolnih žlez, normalizacijo krvnega tlaka, izboljšanjem značilnosti Cushingovega sindroma in izgubo telesne mase.
English: Ketoconazole daily dose should be periodically adjusted on an individual basis with the aim to normalise urinary free cortisol and/or plasma cortisol levels.
Slovenian: Dnevni odmerek ketokonazola je treba redno prilagajati glede na posameznega bolnika, pri čemer mora biti cilj normalizacija ravni prostega kortizola v urinu in/ali kortizola v plazmi.
English: • Intolerance to alcohol
Slovenian: • neprenašanje alkohola,
English: Some combinations may lead to an increased risk of ventricular tachyarrhythmias, including occurrences of torsade de pointes, a potentially fatal arrhythmia (see Table 1 Interactions and recommendations for co-administration, section 4.5).
Slovenian: Nekatere kombinacije lahko povzročijo povečano tveganje ventrikularnih aritmij, vključno s torsade de pointes, morebitno smrtno aritmijo (glejte preglednico 1, Medsebojno delovanje in priporočila za sočasno uporabo, poglavje 4.5).
English: (Relative to Indinavir 800 mg TID alone)
Slovenian: (glede na samostojen indinavir 800 mg trikrat na dan)
English: • Erectile dysfunction
Slovenian: • erektilna disfunkcija,
English: Repeated doses of 200 mg ketoconazole daily resulted in a 17-fold increase in dronedarone exposure
Slovenian: Večkratni odmerki 200 mg ketokonazola na dan so povzročili 17-kratno povečanje izpostavljenosti dronedaronu.
English: At the last visit, 78 patients (49.3%) were controlled, 37 patients (23.4%) had partial control with at least 50% decrease of UFC (without normalisation), and 43 patients (27.2%) had unchanged UFC levels.
Slovenian: 78 bolnikih (49,3 %) nadzorovana, pri 37 (23,4 %) delno nadzorovana z vsaj 50-odstotnim znižanjem ravni prostega kortizola v urinu (brez normalizacije), 43 bolnikov (27,2 %) pa je imelo nespremenjene ravni prostega kortizola v urinu.
English: Data from 17 patients with adrenal tumours and from 2 patients with primary nodular adrenocortical hyperplasia (NAH) treated with ketoconazole are available in the literature along with 17 individual case reports of patients with benign or malignant tumours or NAH and 2 paediatric cases of McCune Albright syndrome.
Slovenian: V literaturi so na voljo podatki o 17 bolnikih z adrenalnimi tumorji in 2 bolnikih s primarno nodularno adrenokortikalno hiperplazijo (NAH), zdravljenih s ketokonazolom, ter 17 poročilih o posameznih primerih bolnikov z benignimi ali malignimi tumorji ali NAH in 2 pediatričnih primerih McCune-Albrightovega sindroma.
English: If you interrupt your treatment with Ketoconazole HRA your cortisol level may increase again and your symptoms may come back.
Slovenian: Če prekinete zdravljenje z zdravilom Ketokonazol HRA, se lahko ravni kortizola znova povišajo in ponovno se lahko pojavijo simptomi.
English: Ketoconazole was not genotoxic in vitro and in vivo.
Slovenian: Ketokonazol in vitro in in vivo ni bil genotoksičen.
English: Use with pasireotide
Slovenian: Uporaba s pasireotidom
English: • Photosensitivity (increase in the reaction to sunlight: redness, itching rash)
Slovenian: • fotosenzitivnost (povečana reakcija na sončno svetlobo: rdečica, srbenje,
English: Ketoconazole did not produce any change in rosuvastatin pharmacokinetics, therefore, co-administration of ketoconazole and rosuvastatin is unlikely to increase the risk of toxicity of rosuvastatin.
Slovenian: Ketokonazol ni spremenil farmakokinetike rosuvastatina, zato ni verjetno, da bo sočasna uporaba ketokonazola in rosuvastatina povečala tveganje toksičnosti rosuvastatina.
English: Vardenafil is contraindicated in men older than 75 years old (see section
Slovenian: Vardenafil je kontraindiciran pri moških, starejših od 75 let (glejte poglavje 4.3).
English: Doses of 25 mg/kg and higher in male rats and dogs produced sperm abnormalities and decreased fertility in rats.
Slovenian: Odmerki 25 mg/kg in večji so povzročili abnormalnosti sperme pri podganjih in pasjih samcih in zmanjšano plodnost pri podganah.
English: Data from 91 patients with the ectopic ACTH syndrome treated with ketoconazole were reviewed, along with 18 individual case reports.
Slovenian: Pregledali so podatke 91 bolnikov s sindromom ektopične sekrecije ACTH, zdravljenih s ketokonazolom, in 18 poročil o posameznih primerih.
English: Not recommended due to a potential increase in colchicine-related toxicity.
Slovenian: Ni priporočljivo zaradi morebitnega povečanja s kolhicinom povezane toksičnosti.
English: In the literature, among 24 paediatric patients treated with ketoconazole, two developed severe hepatoxicity.
Slovenian: V literaturi se je pri dveh od 24 pediatričnih bolnikov, zdravljenih s ketokonazolom, razvila huda hepatotoksičnost.
English: Ketoconazole should not be administered when liver enzymes are greater than 2 times the upper limit of normal or in association with other hepatotoxic medicinal products.
Slovenian: Ketokonazol se ne sme uporabiti, če so ravni jetrnih encimov višje od dvakratne zgornje meje normalnih vrednosti ali v kombinaciji z drugimi hepatotoksičnimi zdravili.
English: When urinary free/serum/ plasma cortisol levels are normalised or close to target and the effective dose of ketoconazole is established, monitoring can be undertaken every 3 to 6 months (see section 4.2 for dose adjustment in case of adrenal insufficiency).
Slovenian: Ko se ravni prostega kortizola v urinu/kortizola v serumu/plazmi normalizirajo ali se približajo ciljni vrednosti in se vzpostavi učinkoviti odmerek ketokonazola, se lahko spremljanje opravlja vsake 3 do 6 mesecev (za prilagajanje odmerka v primeru adrenalne insuficience glejte poglavje 4.2).
English: Antivirals products Saquinavir (saquinavir/ritonavir 1000/100 mg bid)
Slovenian: Sakvinavir (sakvinavir/ritonavir 1000/100 mg dvakrat na dan)
English: • Distortion of the sense of taste
Slovenian: • motnja okusa,
English: Enzyme-inducing medicinal products such as rifampicin, rifabutin, carbamazepine, isoniazid, nevirapine, mitotane and phenytoin may significantly reduce the bioavailability of ketoconazole.
Slovenian: Zdravila, ki inducirajo encime, kot so rifampicin, rifabutin, karbamazepin, isoniazid, nevirapin, mitotan in fenitoin, lahko pomembno zmanjšajo biološko uporabnost ketokonazola.
English: Patients should be advised against alcohol consumption while on treatment (see section 4.5).
Slovenian: Bolnikom je treba svetovati, naj med zdravljenjem ne uživajo alkohola (glejte poglavje 4.5).
English: Vincristine, vinblastine (vinca alkaloids)
Slovenian: Vinkristin, vinblastin (alkaloidi rožnatega zimzelena)
English: - certain medicines for lowering blood cholesterol: simvastatin, atorvastatin, lovastatin
Slovenian: - nekatera zdravila za zniževanje ravni holesterola v krvi: simvastatin, atorvastatin, lovastatin,
English: Concomitant therapy with medicinal products that are contraindicated during treatment with ketoconazole and resulting in potentially life-threatening adverse reactions :
Slovenian: Sočasno zdravljenje z zdravili, ki so kontraindicirana med zdravljenjem s ketokonazolom, in lahko povzročijo morebitno smrtno nevarne neželene učinke:
English: Liver problems can rarely happen (may affect up to 1 in 1,000 people).
Slovenian: Redko se lahko pojavijo težave z jetri (pojavijo se lahko pri največ 1 od 1.000 bolnikov).
English: - certain medicines used for the treatment of the paludism: quinidine, halofantrine - certain medicines used for severe mental health disorders and severe depression: pimozide,
Slovenian: - nekatera zdravila, ki se uporabljajo za zdravljenje malarije: kinidin, halofantrin, - nekatera zdravila, ki se uporabljajo pri hudih duševnih motnjah in hudi depresiji: pimozid,
English: The half-life of ketoconazole increases with dose and duration of treatment.
Slovenian: Razpolovni čas ketokonazola se veča z odmerkom in trajanjem zdravljenja.
English: • Skin reactions (urticaria)
Slovenian: • kožne reakcije (koprivnica),
English: Your doctor will test your blood before you start the treatment and regularly during the treatment to detect any possible abnormalities and also to measure the levels of cortisol.
Slovenian: Pred začetkom zdravljenja in redno med zdravljenjem bo zdravnik opravil krvne preiskave, s katerimi bo odkril kakršne koli morebitne abnormalnosti in izmeril ravni kortizola.
English: Ketoconazole is not carcinogenic.
Slovenian: Ketokonazol ni kancerogen.
English: What you need to know before you take Ketoconazole HRA 3.
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Ketokonazol HRA 3.
English: Telithromycin Clarithromycin
Slovenian: Telitromicin Klaritromicin
English: Mizolastine Halofantrine
Slovenian: Mizolastin Halofantrin
English: Saquinavir: AUC: ↔
Slovenian: Sakvinavir: AUC:↔
English: Maraviroc dose should be decreased to 150 mg twice daily.
Slovenian: Skrbno spremljanje.Odmerek maraviroka je treba zmanjšati na 150 mg dvakrat na dan.
English: The following list is not an inclusive list of interactions between ketoconazole and other medicinal products
Slovenian: Spodnji seznam morda ne vsebuje vseh interakcij med ketokonazolom in drugimi zdravili.
English: Other dihydropyridines Verapamil
Slovenian: Drugi dihidropiridini Verapamil
English: - Ketoconazole inhibits BCRP (Breast Cancer Resistance Protein) in in vitro studies.
Slovenian: - Ketokonazol je v študijah in vitro zaviral BCRP (protein odpornosti proti raku dojke; Breast Cancer Resistance Protein).
English: Medicinal products affecting the absorption of ketoconazole
Slovenian: Zdravila, ki vplivajo na absorpcijo ketokonazola
English: Ketoconazole is extensively metabolised to a large number of inactive metabolites.
Slovenian: Ketokonazol se obsežno presnavlja v veliko število neaktivnih presnovkov.
English: AUC: ↓0.28-fold
Slovenian: AUC: ↓ 0,28-krat
English: • Myalgia (muscle pain)
Slovenian: • mialgija (bolečina v mišicah),
English: In the case of signs suggestive of an adrenal insufficiency, in addition to the general measures to eliminate the medicinal product and reduce its absorption, a 100 mg dose of hydrocortisone should be administered at once, together with saline and glucose infusions.
Slovenian: Če znaki kažejo na adrenalno insuficienco, je treba poleg splošnih ukrepov za izločanje zdravila in zmanjšanje absorpcije takoj uporabiti tudi 100-miligramski odmerek hidrokortizona skupaj z infundiranjem fiziološke raztopine ter glukoze.
English: The most serious adverse reaction is hepatotoxicity, primarily as acute hepatocellular toxicity, but may also result in cholestatic injury or a mixed pattern of toxicity.
Slovenian: Najresnejši neželeni učinek je hepatotoksičnost, predvsem akutna hepatocelularna toksičnost, vendar se lahko kaže tudi s holestatsko poškodbo ali toksičnostjo mešanega vzorca.
English: Ketoconazole at doses of 40 mg/kg/day and higher produces evidence of embryotoxicity and teratogenicity in rats and rabbits.
Slovenian: Pri odmerkih ketokonazola 40 mg/kg/dan in večjih so ugotovili dokaze o embriotoksičnosti in teratogenosti pri podganah in kuncih.
English: Ketoconazole inhibits primarily the activity of 17α-hydroxylase, but it also inhibits 11-hydroxylation steps, and at higher doses the cholesterol side-chain cleavage enzyme.
Slovenian: Ketokonazol primarno zavira dejavnost 17α-hidroksilaze pa tudi korake 11-hidroksilacije, pri večjih odmerkih pa zavira holesterol monooksigenazo.
English: Ketoconazole has also been used with other therapies including surgery and pituitary radiation.
Slovenian: Ketokonazol se je uporabil tudi skupaj z drugimi oblikami zdravljenja, vključno s kirurškim posegom in obsevanjem hipofize.
English: However no modifications of ECG were recorded in dogs at daily doses up to 40 mg/kg administered for 12 months.
Slovenian: Vendar pri psih, ki so prejemali dnevne odmerke do 40 mg/dan 12 mesecev, niso zabeležili nobenih sprememb EKG.
English: Ketoconazole HRA is available in packs containing 60 tablets.
Slovenian: Zdravilo Ketokonazol HRA je na voljo v pakiranju, ki vsebuje 60 tablet.
English: Due to the known hepatotoxicity of ketoconazole, the treatment must not be initiated in patients with liver enzymes levels above 2 times the upper limit of normal (see section 4.3).
Slovenian: Zaradi znane hepatotoksičnosti ketokonazola se zdravljenje ne sme uvesti pri bolnikih z ravnmi jetrnih encimov, ki so višje od dvakratne zgornje meje normalnih vrednosti (glejte poglavje 4.3).
English: * Rosuvastatin is not a CYP 3A4 substrate.
Slovenian: * Rosuvastatin ni substrat CYP 3A4.
English: Potential ↑in AUC of risperidone:
Slovenian: Morebitno ↑ vrednosti AUC risperidona.
English: Specific dosing regimen
Slovenian: Poseben režim odmerjanja
English: - Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP.
Slovenian: - Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Immunosuppressants Everolimus Sirolimus (rapamycin)
Slovenian: Everolimus Sirolimus (rapamicin)
English: - A dose increase of 200 mg/day every 7 to 28 days may be considered if urinary free cortisol and/or plasma cortisol levels are above the normal range, as long as the dose is tolerated by the patient;
Slovenian: - Odmerek lahko vsakih 7 do 28 dni povečate za 200 mg/dan, če so ravni prostega kortizola v urinu in/ali kortizola v plazmi nad normalnimi vrednostmi in bolnik odmerek prenaša.
English: Observed teratogenic effects were mainly skeletal anomalies, including cleft palate, brachydactylia, ectrodactylia and syndactylia.
Slovenian: Opaženi teratogeni učinki so bile večinoma skeletne anomalije, vključno s palatoshizo, brahidaktilijo, ektrodaktilijo in sindaktilijo.
English: There is no known antidote to ketoconazole.
Slovenian: Za ketokonazol ni znanega antidota.
English: Acid-neutralising medicines (e.g. aluminium hydroxide) should not be administered for at least 2 hours after the intake of ketoconazole.
Slovenian: Zdravila za nevtralizacijo kisline (npr. aluminijev hidroksid) se ne smejo uporabiti vsaj 2 uri po zaužitju ketokonazola.
English: Potent inhibitors of CYP3A4 (e.g. antivirals such as ritonavir, ritonavir-boosted darunavir and ritonavirboosted fosamprenavir) may increase the bioavailability of ketoconazole, these medicinal products should be used with caution when co-administered with ketoconazole and patients should be monitored closely for signs and symptoms of adrenal insuficiency.
Slovenian: Močni zaviralci CYP3A4 (npr. protivirusna zdravila, kot so ritonavir, z ritonavirjem okrepljeni darunavir in z ritonavirjem okrepljeni fosamprenavir) lahko povečajo biološko uporabnost ketokonazola, zato je treba ta zdravila uporabljati previdno, kadar se dajejo sočasno s ketokonazolom, pri bolnikih pa je treba skrbno spremljati znake ter simptome adrenalne insuficience.
English: CYP3A4-metabolised and/or P-gp substrates known to prolong the QT interval may be contraindicated or not recommended depending on the observed or expected effect with ketoconazole (i.e. resulting in augmentation of the plasma concentration, AUC, Cmax of the drugs) and the known therapeutic margins of the drugs.
Slovenian: Zdravila, ki se presnavljajo prek CYP3A4, in/ali substrati P-gp, za katere je znano, da podaljšajo interval QT, so lahko kontraindicirani ali odsvetovani, kar je odvisno od opaženega ali pričakovanega učinka s ketokonazolom (tj. povzročijo povečanje koncentracije v plazmi, AUC, Cmaks pri zdravilih) ter znanih terapevtskih mej pri zdravilih.
English: No studies were performed with albumin bound nanoparticules.
Slovenian: nanodelci, ki se vežejo na albumin, niso izvedli nobenih študij.
English: Lurasidone:
Slovenian: Lurasidon:
English: Cmax: ↑ have been observed
Slovenian: Cmax:opazili so ↑.
English: Ketoconazole HRA may temporarily lower the amount of hormones produced by your adrenal gland (cortisol) to below the normal range, but your doctor will correct this using appropriate hormone medicines or by adjusting the dose of Ketoconazole HRA.
Slovenian: Zdravilo Ketokonazol HRA lahko začasno zmanjša količino hormonov, ki jih proizvaja nadledvična žleza (kortizola), pod normalno mejo, vendar bo zdravnik to odpravil z uporabo ustreznih hormonskih zdravil ali prilagoditvijo odmerka zdravila Ketokonazol HRA.
English: In addition, they should receive an emergency card and be equipped with an emergency glucocorticoid set.
Slovenian: Poleg tega morajo prejeti kartico za nujne primere in komplet z glukokortikoidom za nujne primere.
English: In vitro studies have shown that CYP3A4 is the major enzyme involved in the metabolism of ketoconazole.
Slovenian: Študije in vitro so pokazale, da je CYP3A4 glavni encim, vključen v presnovo ketokonazola.
English: Mean peak plasma concentrations of approximately 3.5 μg/ml are reached within 1 to 2 hours, following oral administration of a single 200 mg dose taken with a meal.
Slovenian: Povprečna največja koncentracija v plazmi, ki je približno 3,5 μg/ml, je bila dosežena v 1 do 2 urah po peroralnem zaužitju enkratnega 200-miligramskega odmerka skupaj z obrokom.
English: Do not drive or operate machines if you experience these symptoms.
Slovenian: Če se pri vas pojavijo ti simptomi, ne vozite in ne upravljajte strojev.
English: Cmax: ↓0.56-fold
Slovenian: Cmax: ↓ 0,56-krat
English: Data from 535 patients with Cushing's disease treated with ketoconazole, along with 13 individual case reports are available in the literature.
Slovenian: V literaturi so na voljo podatki za 535 bolnikov s Cushingovo boleznijo, zdravljenih s ketokonazolom, in 13 poročil o posameznih primerih.
English: Data of inhibition indicate that risk of interaction with BCRP substrates cannot be excluded at the systemic level with very high doses of ketoconazole.
Slovenian: Podatki o zaviranju kažejo, da na sistemski ravni pri zelo velikih koncentracijah ketokonazola tveganja za medsebojno delovanje s substrati BCRP ni mogoče izključiti.
English: Ketoconazole is also a potent inhibitor of P-gp: inhibition of P-gp by ketoconazole can increase patients' exposure to medicinal products which are P-gp substrates (see section 4.5).
Slovenian: Ketokonazol je prav tako močan zaviralec P-gp: zaviranje P-gp, ki ga povzroča ketokonazol, lahko poveča bolnikovo izpostavljenost zdravilom, ki so substrati P-gp (glejte poglavje 4.5).
English: In addition, you should receive an emergency card and should be equipped with an emergency glucocorticoid set.
Slovenian: Poleg tega morate prejeti kartico za nujne primere in komplet z glukokortikoidom za nujne primere.
English: Ketoconazole HRA is indicated for the treatment of endogenous Cushing's syndrome in adults and adolescents above the age of 12 years.
Slovenian: Zdravilo Ketokonazol HRA je indicirano za zdravljenje endogenega Cushingovega sindroma pri odraslih in mladostnikih, starejših od 12 let.
English: In reproduction studies, ketoconazole impaired fertility in males and females.
Slovenian: V študijah razmnoževanja je ketokonazol poslabšal plodnost pri samcih in samicah.
English: Adrenal insufficiency may occur in patients on ketoconazole without corticosteroid substitution (block-only regimen) or if there is an insufficient glucocorticoid replacement therapy (for the patients treated with a blockand-replace regimen).
Slovenian: Adrenalna insuficienca se lahko pojavi pri bolnikih, ki prejemajo ketokonazol brez nadomeščanja kortikosteroidov (režim samo z zaviranjem) ali pri katerih je nadomestno zdravljenje z glukokortikoidi nezadostno (režim z zaviranjem in nadomeščanjem).
English: Not recommended as it may increase ibrutinib-related toxicity.
Slovenian: Ni priporočljivo zaradi povečanja toksičnosti, povezane z ibrutinibom.
English: Medicines that can interact with Ketoconazole HRA include: - pasireotide, another drug used to treat a subset of the Cushing's syndrome because it can lead to severe side effects in patients suffering from cardiac disorders - medicines taken by mouth that prevent blood clots from forming: rivaroxaban, apixaban, edoxaban,
Slovenian: Zdravila, ki lahko medsebojno delujejo z zdravilom Ketokonazol HRA, vključujejo: - pasireotid, drugo zdravilo, ki se uporablja za zdravljenje podvrste Cushingovega sindroma, saj lahko povzroči hude neželene učinke pri bolnikih s srčnimi motnjami; - zdravila, ki se zaužijejo skozi usta in preprečujejo nastajanje krvnih strdkov: rivaroksaban, apiksaban,
English: About 75% of patients achieved a decrease of more than 50% of UFC levels on ketoconazole, compared to pre-treatment levels
Slovenian: Pri približno 75 % bolnikih je bilo znižanje ravni prostega kortizola v urinu več kot 50-odstotno v primerjavi z ravnmi pred zdravljenjem.