FrancophonIA/ELRC3.0 huggingface dataset:
English: • an increase in protein in the urine, an increase in cholesterol in the blood, and swelling from excess fluid (oedema) (also called ‘nephrotic syndrome')
Croatian: • povišene vrijednosti proteina u mokraći, povišene vrijednosti kolesterola u krvi i oticanje zbog prekomjerne količine tekućine (edem) (poznato i kao ‘nefrotski sindrom')
English: Aflibercept, also known as VEGF TRAP in the scientific literature, is a recombinant fusion protein consisting of VEGF-binding portions from the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of the human IgG1.
Croatian: Aflibercept, u znanstvenoj literaturi poznat i kao VEGF TRAP, je rekombinantni fuzijski protein koji se sastoji od dijelova izvanstaničnih domena humanih VEGF receptora 1 i 2 spojenih za dio
English: Zaltrap may increase blood pressure (see section 4) and your doctor will need to monitor your blood pressure and may adjust your blood pressure medicines or your dose of ZALTRAP.
Croatian: ZALTRAP može povisiti krvni tlak (vidjeti dio 4.) pa će Vam liječnik morati kontrolirati krvni tlak i možda prilagoditi dozu lijekova za regulaciju krvnog tlaka ili dozu lijeka ZALTRAP.
English: It is recommended to monitor blood pressure every two weeks, including before each administration or as clinically indicated during treatment with aflibercept.
Croatian: Preporučuje se kontrolirati krvni tlak svaka dva tjedna, uključujući prije svake primjene aflibercepta ili prema kliničkoj potrebi tijekom liječenja.
English: • feeling tired or weak
Croatian: • osjećaj umora ili slabosti
English: Paediatric population The safety in paediatric patients has not been established.
Croatian: Nije utvrđena sigurnost primjene u pedijatrijskoj populaciji.
English: Contact your doctor and dentist immediately during and after treatment with ZALTRAP if you experience any problems with your mouth or teeth such as loose teeth, pain or swelling, or non-healing of sores or discharge, as these could be signs of osteonecrosis of the jaw.
Croatian: Odmah kontaktirajte Vašeg liječnika i stomatologa ako tijekom i nakon liječenja lijekom ZALTRAP iskusite bilo kakav problem s usnom šupljinom ili zubima, kao što su klimanje zubiju, bol ili oticanje, rane koje ne zacijeljuju ili iscjedak jer to mogu biti znakovi osteonekroze čeljusti.
English: PlGF is also linked to pathological neovascularisation and recruitment of inflammatory cells into tumours.
Croatian: PlGF se također povezuje s patološkom neovaskularizacijom i uključivanjem upalnih stanica u tumore.
English: It is recommended that aflibercept not be initiated for at least 4 weeks following major surgery and not until the surgical wound is fully healed.
Croatian: Preporučuje se ne započinjati liječenje afliberceptom barem 4 tjedna nakon većeg kirurškog zahvata i dok kirurška rana u potpunosti ne zacijeli.
English: ZALTRAP is to be administered only as an intravenous infusion over 1 hour.
Croatian: ZALTRAP se primjenjuje isključivo u obliku intravenske infuzije tijekom razdoblja od 1 sata.
English: Frequencies are based on all grades and defined as: very common (≥ 1/10), common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000); not known (cannot be estimated from the available data).
Croatian: < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000); nepoznato (ne može se procijeniti iz dostupnih podataka).
English: ZALTRAP/FOLFIRI should be discontinued and appropriate medical therapy should be administered.
Croatian: Treba obustaviti primjenu protokola ZALTRAP/FOLFIRI i primijeniti odgovarajuće liječenje.
English: Gender was the most significant covariate for explaining the interindividual variability of free aflibercept clearance and volume with a 15.5 % higher clearance and a 20.6 % higher volume of distribution in males than in females.
Croatian: Spol je bila najznačajnija kovarijanta kojom se mogla objasniti interindividualna varijabilnost kada su u pitanju klirens i volumen slobodnog aflibercepta; naime, u muškaraca je klirens bio 15,5% veći, a volumen distribucije 20,6% veći nego u žena.
English: High molecular weight proteins are not cleared by the renal route, therefore renal elimination of aflibercept is expected to be minimal.
Croatian: Proteini visoke molekularne težine ne uklanjaju se iz tijela bubrezima, pa se očekuje minimalna eliminacija aflibercepta putem bubrega.
English: If you develop such a connection or passageway during treatment, your doctor will stop your treatment with ZALTRAP.
Croatian: Ako Vam se za vrijeme liječenja stvori takva poveznica ili prolaz, liječnik će prekinuti liječenje lijekom ZALTRAP.
English: VTE include deep venous thrombosis and pulmonary embolism.
Croatian: VTE uključuju duboku vensku trombozu i plućnu emboliju.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C unless dilution has taken place in controlled and validated aseptic conditions.
Croatian: Ako se ne primijeni odmah, trajanje i uvjeti čuvanja do primjene lijeka odgovornost su korisnika i ne bi smjeli biti dulji od 24 sata na temperaturi od 2°C do 8°C, osim ako je razrjeđivanje provedeno u kontroliranim i validiranim aseptičkim uvjetima.
English: In sexually mature male cynomolgus monkeys a decrease in sperm motility and an increase in incidence of morphological abnormalities of spermatozoa were observed.
Croatian: U spolno zrelih mužjaka makaki majmuna primijećena je smanjena pokretljivost spermija i povećana incidencija morfoloških anomalija spermatozoida.
English: For minor surgery such as central venous access port placement, biopsy, and tooth extraction, aflibercept may be initiated/restarted once the surgical wound is fully healed.
Croatian: Za manje kirurške zahvate, poput uvođenja centralnog venskog katetera, biopsije i vađenja zuba, aflibercept se može (ponovno) početi primjenjivati nakon što kirurška rana u potpunosti zacijeli.
English: There are very limited data in patients with severe renal impairment; therefore, these patients should be treated with caution.
Croatian: Podaci o primjeni u bolesnika s teškim oštećenjem bubrežne funkcije su vrlo ograničeni; stoga te bolesnike treba liječiti s oprezom.
English: Most aflibercept-related findings were noted from the lowest dose tested corresponding to plasma exposures close to those in patients at the therapeutic dose.
Croatian: Većina nalaza povezanih s afliberceptom primijećena je pri najnižoj ispitivanoj dozi kod koje je izloženost u plazmi slična onoj u bolesnika kod primjene terapijske doze.
English: There are no data available for patients with severe hepatic impairment (total bilirubin > 3 x ULN and any AST).
Croatian: Nema dostupnih podataka o primjeni u bolesnika s teškim oštećenjem jetrene funkcije (ukupni bilirubin > 3 x GGN i bilo koja vrijednost AST-a).
English: If you experience any of these symptoms, talk to your doctor immediatley since your doctor may want to treat your symptoms and stop your treatment with ZALTRAP.
Croatian: Ako primijetite neki od navedenih simptoma, odmah se obratite liječniku jer će možda htjeti liječiti simptome i prekinuti liječenje lijekom
English: If recurrence after irinotecan and 5-FU dose reductions, reduction of ZALTRAP dose to 2 mg/kg could be considered.
Croatian: Ako se ponovno javi nakon smanjenja doze irinotekana i 5-FU, treba razmotriti smanjenje doze lijeka ZALTRAP na 2 mg/kg.
English: The signs of a blood clot may vary depending on where it appears (e.g. lungs, leg, heart or brain) but may include symptoms such as chest pain, coughing, being short of breath or having difficulty breathing.
Croatian: Znakovi krvnog ugruška mogu se razlikovati ovisno o tome gdje se ugrušak pojavi (npr. u plućima, nozi, srcu ili mozgu), ali mogu uključivati simptome poput boli u prsima, kašlja, nedostatka zraka ili otežanog disanja.
English: Administration of aflibercept to mice bearing xenotransplant or allotransplant tumours inhibited the growth of various cancer types.
Croatian: Primjena aflibercepta u miševa s ksenotransplantacijskim i alotransplantacijskim tumorima inhibirala je rast različitih vrsta raka.
English: • Grade 4 venous thromboembolic events (including pulmonary embolism)
Croatian: • venskih tromboembolijskih događaja stupnja 4 (uključujući plućnu emboliju)
English: • you have ever had any allergies - serious allergic reactions can happen during treatment with ZALTRAP (see section 4).
Croatian: • ako ste ikada imali bilo kakvu alergiju - tijekom liječenja lijekom ZALTRAP mogu nastupiti teške alergijske reakcije (vidjeti dio 4.).
English: • difficulty when breathing
Croatian: • otežano disanje
English: ZALTRAP may affect male and female fertility.
Croatian: ZALTRAP može utjecati na plodnost u muškaraca i žena.
English: The medicine must be diluted before it is given.
Croatian: Lijek se mora razrijediti prije primjene.
English: PRACTICAL INFORMATION FOR HEALTHCARE PROFESSIONALS ON PREPARATION AND HANDLING OF ZALTRAP 25 mg / ml CONCENTRATE FOR SOLUTION FOR INFUSION
Croatian: PRAKTIČNE INFORMACIJE ZA ZDRAVSTVENE RADNIKE O PRIPREMI I RUKOVANJU ZALTRAP 25 mg/ml KONCENTRATOM ZA OTOPINU ZA INFUZIJU
English: This population pharmacokinetic analysis revealed no clinically meaningful differences in clearance or systemic exposure (AUC) of free aflibercept in patients with moderate and mild renal impairment at the 4 mg/kg dose of ZALTRAP as compared to the overall population studied.
Croatian: Ta populacijska farmakokinetička analiza nije ukazala na značajne razlike u klirensu niti sustavnoj izloženosti (AUC) slobodnom afliberceptu u bolesnika s umjerenim ili blagim oštećenjem bubrežne funkcije pri dozi lijeka ZALTRAP od 4 mg/kg u usporedbi s cjelokupnom ispitivanom populacijom.
English: The efficacy and safety of ZALTRAP were evaluated in a randomised, double-blind, placebo-controlled study in patients with metastatic colorectal cancer who had previously been treated with an oxaliplatin-based treatment with or without prior bevacizumab.
Croatian: Djelotvornost i sigurnost primjene lijeka ZALTRAP ocijenjene su u randomiziranom, dvostruko slijepom, placebom kontroliranom ispitivanju u bolesnika s metastatskim kolorektalnim karcinomom koji su prethodno bili liječeni terapijom na bazi oksaliplatina, uz prethodnu primjenu bevacizumaba ili bez nje.
English: • you have kidney problems (protein in the urine), since your doctor will monitor your kidney function and may need to adjust your dose of ZALTRAP.
Croatian: • ako imate tegobe s bubrezima (proteine u mokraći); liječnik će kontrolirati funkciju bubrega i možda će trebati prilagoditi dozu lijeka ZALTRAP.
English: In the event of recurrence, despite appropriate anticoagulation, aflibercept treatment should be discontinued.
Croatian: U slučaju ponovne pojave unatoč odgovarajućoj antikoagulantnoj terapiji, liječenje afliberceptom treba prekinuti.
English: • polypropylene
Croatian: • polipropilena
English: Aflibercept should be permanently discontinued if hypertension cannot be adequately managed with appropriate anti-hypertensive therapy or aflibercept dose reduction, or if hypertensive crisis or hypertensive encephalopathy occurs (see section 4.2).
Croatian: Primjenu aflibercepta treba trajno prekinuti ako se hipertenziju ne može adekvatno liječiti antihipertenzivima ili smanjenjem doze aflibercepta te u slučaju hipertenzivne krize ili hipertenzivne encefalopatije (vidjeti dio 4.2).
English: • Nephrotic syndrome or thrombotic microangiopathy (TMA)
Croatian: • nefrotskog sindroma ili trombotičke mikroangiopatije (TMA)
English: Therapeutic use of G-CSF at first occurrence of grade ≥ 3 neutropenia and secondary prophylaxis may be considered in patients who may be at increased risk for neutropenia complications.
Croatian: Može se razmotriti terapijska primjena G-CSF kod prve pojave neutropenije stupnja ≥ 3 i sekundarna profilaksa u bolesnika u kojih postoji povećan rizik od neutropenijskih komplikacija.
English: • Allergic reactions: Common (may affect up to 1 in 10 people) - these may happen within a few minutes after your infusion.
Croatian: • Alergijske reakcije: Često (mogu se javiti u manje od 1 na 10 osoba) - mogu se javiti unutar nekoliko minuta nakon infuzije.
English: Aflibercept should be suspended for at least 4 weeks prior to elective surgery.
Croatian: Primjena aflibercepta mora se privremeno prekinuti najmanje 4 tjedna prije elektivnog kirurškog zahvata.
English: • polyvinyl chloride (PVC) containing bis(2-ethylhexyl) phthalate (DEHP)
Croatian: • polivinilklorida (PVC) koji sadrži bis(2-etilheksil)ftalat (DEHP)
English: EU/1/12/814/001 1 vial (100 mg/4 ml) EU/1/12/814/002 3 vials (100 mg/4 ml) EU/1/12/814/003 1 vial (200 mg/8 ml)
Croatian: EU/1/12/814/002 3 bočice (100 mg/4 ml) EU/1/12/814/003 1 bočica (200 mg/8 ml)
English: 11.1 (8.5 to 13.8)
Croatian: 11,1 (8,5 do 13,8)
English: High-titre antibody responses to aflibercept were not detected in any patients.
Croatian: Odgovor s visokim titrom protutijela na aflibercept nije utvrđen ni u jednoga bolesnika.
English: • Dilute it to the required administration volume with sodium chloride 9 mg / ml (0.9 %) solution or 5 % glucose solution for infusion.
Croatian: • Razrijedite lijek do volumena potrebnog za primjenu otopinom natrijeva klorida od 9 mg/ml (0,9%) ili 5%-tnom otopinom glukoze za infuziju.
English: Talk to your doctor straight away, if you notice any of the side effects above.
Croatian: Odmah obavijestite liječnika ako primijetite neku od gore navedenih nuspojava.
English: There was no observed impact on the pharmacokinetic profile of aflibercept in patients who were positive in the immunogenicity assays.
Croatian: Nije primijećen učinak na farmakokinetički profil aflibercepta u bolesnika s pozitivnim nalazima testa imunogenosti.
English: The incidence of diarrhoea, dizziness, asthenia, weight decrease, and dehydration was increased by ≥5% in elderly compared to younger patients.
Croatian: Incidencija proljeva, omaglice, astenije, smanjenja tjelesne težine i dehidracije bila je ≥ 5% veća u starijih nego u mlađih bolesnika.
English: Your doctor will stop this medicine for at least 4 weeks before planned surgery and until the wound is fully healed.
Croatian: Liječnik će prekinuti primjenu ovoga lijeka najmanje 4 tjedna prije zakazane operacije i dok rana u potpunosti ne zacijeli.
English: Given the similar ADA assay results in patients treated with placebo or ZALTRAP, the actual incidence of immunogenicity with ZALTRAP based on these assays is likely to be overestimated.
Croatian: S obzirom na slične rezultate ADA testa u bolesnika koji primaju placebo ili ZALTRAP, stvarna incidencija imunogenosti kod primjene lijeka ZALTRAP utemeljena na tim testovima vjerojatno je precijenjena.
English: If this should happen to you, your doctor will stop your treatment with ZALTRAP.
Croatian: Ako se to dogodi Vama, liječnik će prekinuti liječenje lijekom ZALTRAP.
English: ZALTRAP is a medicine used to treat advanced cancers of the colon or rectum (parts of the large intestine) in adults.
Croatian: ZALTRAP je lijek koji se koristi za liječenje uznapredovalog raka kolona ili rektuma (dijelova debelog crijeva) u odraslih osoba.
English: Seventeen (17) patients treated with ZALTRAP (1.6 %) and two (2) placebo-treated patients (0.2 %) were also positive in the neutralising antibody assay.
Croatian: Sedamnaest (17) bolesnika liječenih lijekom ZALTRAP (1,6%) i dva (2) bolesnika koja su primala placebo također su imali pozitivan nalaz testa na neutralizirajuća protutijela.
English: Febrile neutropenia or neutropenic sepsis
Croatian: Neutropenijska vrućica ili neutropenijska sepsa
English: Adverse reactions in Table 1 are defined as either any adverse clinical reaction or laboratory abnormality having ≥ 2 % greater incidence (all grades) in the aflibercept treatment group in comparison to the placebo treatment group in the MCRC study including those that do not meet this threshold but were consistent with the anti-VEGF class and were seen in any study with aflibercept.
Croatian: Nuspojave u Tablici 1 definirane su kao bilo koja klinička nuspojava ili laboratorijsko odstupanje za koje je u ispitivanju MKRK-a incidencija (svih stupnjeva) bila ≥ 2% veća u skupini liječenoj afliberceptom u usporedbi s incidencijom u skupini koja je primala placebo, uključujući nuspojave koje nisu dosegle ovu graničnu vrijednost, ali su odgovarale anti-VEGF razredu i primijećene su u bilo kojem ispitivanju aflibercepta.
English: Do not use ZALTRAP: • if you are allergic to aflibercept or any of the other ingredients of this medicine (listed in section
Croatian: • ako ste alergični na aflibercept ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: The concentration of the final ZALTRAP solution for intravenous infusion should be kept within the range of 0.6 mg/ml to 8 mg/ml of aflibercept.
Croatian: Koncentracija konačne ZALTRAP otopine za intravensku infuziju mora se kretati u rasponu od 0,6 mg/ml do 8 mg/ml aflibercepta.
English: This population included; 549 patients with mild renal impairment (CL CR between 50-80 ml/min), 96 patients with moderate renal impairment (CL CR between 30-50 ml/min), and 5 patients with severe renal impairment (CL CR < 30 ml/min).
Croatian: Navedena je populacija uključivala 549 bolesnika s blagim oštećenjem bubrežne funkcije (CLCR između 50-80 ml/min), 96 bolesnika s umjerenim oštećenjem bubrežne funkcije (CLCR između 30-50 ml/min) i 5 bolesnika s teškim oštećenjem bubrežne funkcije (CLCR < 30 ml/min).
English: ZALTRAP contains the active substance aflibercept, a protein that works by blocking the growth of new blood vessels within the tumour.
Croatian: ZALTRAP sadrži djelatnu tvar aflibercept, protein koji djeluje tako da blokira rast novih krvnih žila unutar tumora.
English: ZALTRAP treatment should be continued until disease progression or unacceptable toxicity occurs.
Croatian: Liječenje lijekom ZALTRAP treba nastaviti do progresije bolesti ili do pojave neprihvatljive toksičnosti.
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati ZALTRAP Lijek čuvajte izvan pogleda i dohvata djece.
English: Pack size of 1 vial or 3 vials.
Croatian: Pakiranje od 1 ili 3 bočice.
English: Talk to your doctor before being given this medicine if you are breast-feeding.
Croatian: Obratite se svom liječniku prije nego primite ovaj lijek ako dojite.
English: In the few patients with severe renal impairment, drug exposure was similar to that observed in patients with normal renal function.
Croatian: U malobrojnih bolesnika s teškim oštećenjem bubrežne funkcije izloženost lijeku bila je slična onoj primijećenoj u bolesnika s normalnom bubrežnom funkcijom.
English: Immunogenicity As with all therapeutic proteins, there is a potential for immunogenicity with ZALTRAP.
Croatian: Kao i svi terapijski proteini, ZALTRAP može imati imunogeno djelovanje.
English: What ZALTRAP is and how it works
Croatian: Što je ZALTRAP i za što se koristi Što je ZALTRAP i kako djeluje
English: Demographics were well balanced between the treatment arms (age, race, ECOG performance status, and prior bevacizumab status).
Croatian: Bolesnici su bili ravnomjerno raspoređeni u skupine s obzirom na demografske karakteristike (dob, rasa, ECOG status i status prethodnog liječenja bevacizumabom).
English: • Pain in the mouth, teeth and/or jaw, swelling or non-healing sores in the mouth or jaw, discharge, numbness or a feeling of heaviness in the jaw, or loosening of a tooth: Uncommon (may affect up to 1 in 100 people) - These symptoms could be signs of bone damage in the jaw (osteonecrosis).
Croatian: • Bolovi u usnoj šupljini, zubima i/ili čeljusti, oticanje ili rane koje ne zacjeljuju u usnoj šupljini ili čeljusti, iscjedak, utrnulost ili osjećaj težine u čeljusti, ili klimanje zuba: Manje često (mogu se javiti u manje od 1 na 100 osoba) - Ti simptomi mogu biti znakovi oštećenja kostiju čeljusti (osteonekroza).
English: In full-thickness excisional and incisional skin wound models, aflibercept administration reduced fibrous response, neovascularisation, epidermal hyperplasia/re-epithelialisation, and tensile strength.
Croatian: U modelima ekscizijskih i incizijskih rana pune debljine kože primjena aflibercepta smanjila je fibrozni odgovor, neovaskularizaciju, epidermalnu hiperplaziju/ponovnu epitelizaciju i otpor na istezanje.
English: Patients with NYHA class III or IV congestive heart failure should not be treated with ZALTRAP.
Croatian: Bolesnike s kongestivnim zatajenjem srca NYHA stupnja III ili IV ne smije se liječiti lijekom ZALTRAP.
English: The concentrate is a clear colourless to pale yellow solution.
Croatian: Koncentrat je bistra, bezbojna do blijedo žuta otopina.
English: • you have had any abnormal tube-like connections or passageways inside the body between internal organs and skin or other tissues (also called ‘fistula').
Croatian: • ako imate abnormalne poveznice ili prolaze u obliku cjevčice u tijelu između unutarnjih organa i kože ili drugih tkiva (nazivaju se i ‘fistule').
English: • your number of white blood cells is too low.
Croatian: • ako imate premalen broj bijelih krvnih stanica.
English: Consistent with target-mediated drug disposition, free aflibercept exhibits a faster (non-linear) clearance at doses below 2 mg/kg, likely due to the high affinity binding of aflibercept to endogenous VEGF.
Croatian: U skladu s ciljno posredovanom dispozicijom lijeka, slobodni aflibercept ima brži (nelinearni) klirens pri dozama manjima od 2 mg/kg, što je vjerojatno posljedica visokog afiniteta vezivanja aflibercepta za endogeni VEGF.
English: In these mild and moderate hepatic impairment patients, there was no effect on clearance of aflibercept.
Croatian: U tih bolesnika s blagim ili umjerenim oštećenjem jetrene funkcije nije bilo učinka na klirens aflibercepta.
English: Your doctor will do blood tests regularly to check your white blood cell counts throughout your treatment.
Croatian: Liječnik će tijekom cijelog liječenja redovito kontrolirati krvnu sliku kako bi provjerio broj bijelih krvnih stanica.
English: Other signs include feeling confused, problems with sight, walking, coordination or balance, problems in saying words or slurring of speech.
Croatian: Drugi znakovi uključuju smetenost, tegobe s vidom, hodom, koordinacijom ili ravnotežom, poteškoće u izgovaranju riječi ili nerazgovijetan govor.
English: ZALTRAP Treatment delay and dose modification
Croatian: ZALTRAP - Odgoda liječenja i prilagodba doze
English: While being treated with ZALTRAP, you should maintain good oral hygiene (including regular teeth brushing) and receive routine dental check-ups.
Croatian: Dok se liječite lijekom ZALTRAP, trebate održavati dobru oralnu higijenu (uključujući redovito pranje zubi) i redovito odlaziti na stomatološke preglede.Ako imate zubnu protezu trebate se pobrinuti da je prikladno namještena.
English: Patients with a dipstick of ≥ 2+ for protein or a UPCR > 1 or a protein/creatinine ratio (PCR)> 100 mg/mmol should undergo a 24-hour urine collection.
Croatian: U bolesnika s rezultatima analize pomoću test trakica ≥ 2+ za proteine ili s omjerom proteina i kreatinina u mokraći > 1 ili s omjerom proteina i kreatinina > 100 mg/mmol treba izvršiti 24-satno prikupljanje mokraće.
English: Carcinogenesis and mutagenesis No studies have been conducted to evaluate carcinogenicity or mutagenicity of aflibercept.
Croatian: Nisu provedena ispitivanja kojima bi se ocijenila kancerogenost ili mutagenost aflibercepta.
English: The most commonly observed adverse reactions at these doses were similar to those observed at the therapeutic dose.
Croatian: Najčešće prijavljene nuspojave pri tim dozama slične su nuspojavama primijećenima kod primjene terapijske doze.
English: Aflibercept blocks the activation of VEGF receptors and the proliferation of endothelial cells, thereby inhibiting the growth of new vessels that supply tumours with oxygen and nutrients.
Croatian: Aflibercept blokira aktivaciju VEGF receptora i proliferaciju endotelnih stanica te tako inhibira rast novih krvnih žila koje tumore opskrbljuju kisikom i hranjivim tvarima.