FrancophonIA/ELRC3.0 huggingface dataset:
English: Although these adverse reactions are believed to be related to the ergoline structure of these compounds, whether other, nonergot derived dopamine agonists can cause them is unknown.
Croatian: Iako se te nuspojave povezuju s ergolinskom strukturom tih sastojaka, nije poznato mogu li ih uzrokovati i agonisti dopamina koji nisu dobiveni iz ergota.
English: In a placebo-controlled, 7-week trial polysomnographic parameters were investigated.
Croatian: U placebom kontroliranom 7- tjednom ispitivanju bili su proučavani polisomnografski parametri.
English: Skin problems caused by the patch
Croatian: Promjene na koži uzrokovane flasterom
English: Leganto is for transdermal use.
Croatian: Leganto je za transdermalnu primjenu.
English: After 6 months of maintenance treatment in patients with moderate to severe RLS, the baseline IRLS score improved from 30.7 to 20.7 for placebo and from 30.2 to 13.8 for rotigotine.
Croatian: Nakon terapije održavanja u trajanju od 6 mjeseci u bolesnika s umjerenim do teškim oblikom sindroma nemirnih nogu, početne IRLS vrijednosti su se poboljšale s 30,7 na 20,7 za placebo i s 30,2 na 13,8 za rotigotin.
English: The Leganto treatment initiation pack contains 4 different packages (one for each strength) with 7 patches in each package.
Croatian: Leganto pakiranje za započinjanje liječenja sadrži 4 različita pakiranja (jedno od svake jačine), s po 7 flastera u svakom pakiranju.
English: After a single dose of rotigotine, binding to melanin-containing tissues (i.e., eyes) in the pigmented rat and monkey was evident, but was slowly cleared over the 14-day observation period.
Croatian: Nakon jedne doze rotigotina, u pigmentiranog štakora i majmuna je bilo evidentno njegovo vezanje za tkiva koja sadržavaju melanim (tj. oči), ali se nakon perioda promatranja od 14 dana postupno smanjilo.
English: Dosing in patients with advanced stage Parkinson's disease with fluctuations:
Croatian: Doziranje u bolesnika u uznapredovaloj fazi Parkinsonove bolesti s fluktuacijama:
English: Two pivotal trials (SP512 Part I and SP513 Part I) investigating the effectiveness of rotigotine in the treatment of the signs and symptoms of idiopathic Parkinson's disease were conducted in patients who were not receiving concomitant dopamine agonist therapy and were either L-dopa naïve or previous L-dopa treatment was ≤ 6 months.
Croatian: Dva pivotalna ispitivanja (SP512 I dio i SP513 I dio) učinkovitosti rotigotina u liječenju znakova i simptoma idiopatske Parkinsonove bolesti provedena su u bolesnika koji nisu uzimali prateću terapiju agonistima dopamina i nisu nikad uzimali L-dopu ili je prethodno liječenje L-dopom trajalo ≤6 mjeseci.
English: • increased sex drive
Croatian: • pojačan spolni nagon
English: After use the patch still contains active substance.
Croatian: Flaster nakon primjene još uvijek sadrži djelatnu tvar.
English: urges to move around, sleep disturbance and feeling tired or sleepy during the day.
Croatian: neodoljivom potrebom za kretanjem, poremećajem spavanja te umorom ili pospanošću tijekom dana.
English: If you are not sure about this, talk to your doctor or pharmacist first.
Croatian: Ako niste sigurni, najprije razgovarajte sa svojim liječnikom ili ljekarnikom.
English: Neuroleptics given as antiemetic should not be given to patients taking dopamine agonists (see also section 4.5).
Croatian: Bolesnicima koji uzimaju agoniste dopamina, ne smiju se davati neuroleptici za sprečavanje povraćanja (vidjeti također dio 4.5).
English: • Do not stick the patch on broken or damaged skin - or on skin that is red or irritated.
Croatian: • Nemojte lijepiti flaster na ozlijeđenu, oštećenu, crvenu ili nadraženu kožu.
English: Because of possible additive effects, caution should be advised when patients are taking sedating medicinal products or other CNS (central nervous system) depressants (e.g. benzodiazepines, antipsychotics, antidepressants) or alcohol in combination with rotigotine.
Croatian: Potreban je oprez u bolesnika koji uzimaju sedative ili druge depresore središnjeg živčanog sustava (npr. benzodiazepine, antipsihotike, antidepresive) ili alkohol u kombinaciji s rotigotinom zbog mogućih aditivnih učinaka.
English: • Parkinson's disease - Leganto can be used on its own or with another medicine called levodopa.
Croatian: - Leganto se može koristiti kao jedini lijek ili u kombinaciji s još jednim lijekom koji se zove levodopa.
English: Treatment initiation pack
Croatian: Pakiranje za početak terapije
English: At the beginning of therapy dopaminergic adverse reactions such as nausea and vomiting may occur.
Croatian: Na početku terapije mogu se javiti dopaminergičke nuspojave poput mučnine i povraćanja.
English: • If you need to stick the patch to a hairy area of skin, you must shave the area at least 3 days before sticking the patch there.
Croatian: • Ako morate nalijepiti flaster na kožu prekrivenu dlakama, morate obrijati to područje najmanje
English: • visual disturbances such as seeing colours or lights
Croatian: • poremećaji vida, primjerice percepcije boja i svjetla
English: Each pack of 28 transdermal patches for a 4 week treatment schedule contains: 7 transdermal patches of Leganto 2 mg/24 h
Croatian: Jedno pakiranje od 28 transdermalnih flastera za raspored liječenja tijekom 4 tjedna sadrži: 7 transdermalnih flastera Leganta 2 mg/24 h
English: • Release liner: Transparent fluoropolymer coated polyester film.
Croatian: • Zaštitni sloj: poliesterski film obložen prozirnim fluoropolimerom.
English: 116 patients were switched from previous oral therapy to receive up to 8 mg/24 h of rotigotine, among these were 47 who had been treated with ropinirole up to 9 mg/day, 47 who had been treated with pramipexole up to 2 mg/day and 22 who had been treated with cabergoline up to 3 mg/day.
Croatian: U 116 bolesnika zamijenjena je prethodna oralna terapija s davanjem do 8 mg/24 h rotigotina, a među njima je bilo 47 njih koji su liječeni ropinirolom do 9 mg/dan, njih 47 koji su liječeni pramipeksolom do 2 mg/dan i njih 22 koji su liječeni kabergolinom do 3 mg/dan.
English: It is thin and has three layers.
Croatian: Flaster je tanak i sastoji se od tri sloja.
English: Very common Common Uncommon Rare
Croatian: Manje često Rijetko Nepoznato
English: • generalised rash
Croatian: • generalizirani osip
English: Using higher doses of Leganto than your doctor has prescribed may cause side effects such as feeling sick (nausea) or vomiting, low blood pressure, seeing or hearing things that are not real (hallucinations), feeling confused, very sleepy, having involuntary movements and convulsions.
Croatian: Ako ste slučajno nalijepili više Leganto flastera nego što Vam je liječnik propisao, mogu se javiti sljedeće nuspojave: mučnina ili povraćanje, nizak krvni tlak, halucinacije (vidite ili čujete stvari koje nisu stvarne), smetenost, jaka pospanost, nekontrolirani pokreti i konvulzije.
English: • metoclopramide - used to treat nausea (feeling sick) and vomiting.
Croatian: • metoklopramid - koristi se za liječenje mučnine i povraćanja.
English: Where to stick the patch Put the sticky side of the patch onto clean, dry, healthy skin on the following areas as shown in grey on the pictures opposite:
Croatian: Gdje trebate nalijepiti flaster Postavite ljepljivu stranu flastera na čistu, suhu i zdravu kožu na sljedeća područja, označena sivom bojom na slici:
English: You may find it helpful to tell a member of your family or carer that you are using this medicine and ask them to read this leaflet.
Croatian: Možda bi bilo dobro da kažete članu svoje obitelji ili njegovatelju da uzimate ovaj lijek i zamolite ih da pročitaju ovu uputu.
English: The difference was 5.28 points and statistically significant (p<0.0001).
Croatian: Razlika je bila 5,28 bodova, što je bilo i statistički značajno (p < 0,0001).
English: This makes sure the patch is touching the skin and the edges stick down well.
Croatian: Tako će se flaster dobro priljubiti uz kožu, a rubovi dobro zalijepiti.
English: External heat (excessive sunlight, heating pads and other sources of heat such as sauna, hot bath) should not be applied to the area of the patch.
Croatian: Vanjsko zagrijavanje (prekomjerna sunčeva svetlost, primjena lokalnih grijača i drugih izvora topline kao sauna ili vruća kupka) ne smije se primjenjivati u području flastera.
English: • dropped head syndrome
Croatian: • sindrom spuštene glave
English: Steady-state concentrations are reached after one to two days of patch application and are maintained at a stable level by once daily application in which the patch is worn for 24 hours.
Croatian: Koncentracije stanja dinamičke ravnoteže postižu se nakon jedan do dva dana primjene flastera i održavaju se na stabilnim vrijednostima svakodnevnom primjenom jednog flastera koji bolesnik nosi 24 sata.
English: Treatment differences for the coprimary variables were statistically significant (p=0.0002 and p<0.0001).
Croatian: Razlike u liječenju za primarne varijable bile su statistički značajne (p=0,0002, odnosno p<0,0001).
English: • For doses higher than 8 mg/24 h (doses prescribed by your doctor above the available strengths), multiple patches must be applied to achieve the final dose.
Croatian: • Za doze veće od 8 mg/24 h (doze koje je propisao Vaš liječnik a koje su iznad dostupnih jačina), trebate primijeniti više flastera kako biste postigli konačnu dozu.
English: Peel off sachet in a plastic box: One side is composed of an ethylene copolymer (innermost layer), an aluminium foil, low density polyethylene film and paper; the other side is composed of polyethylene (innermost layer), aluminium, ethylene copolymer and paper.
Croatian: Zaštitna vrećica u plastičnoj kutiji: s jedne je strane napravljena od etilenskog kopolimera (unutarnji sloj), aluminijske folije, polietilenskog filma niske gustoće i papira; s druge strane od polietilena (unutarnji sloj), aluminija, etilenskog kopolimera i papira.
English: Abnormal thinking and behaviour have been reported and can consist of a variety of manifestations including paranoid ideation, delusions, hallucinations, confusion, psychotic-like behaviour, disorientation, aggressive behaviour, agitation, and delirium.
Croatian: Zabilježeni su abnormalno razmišljanje i ponašanje i mogu se manifestirati paranoidnim idejama, deluzijama, halucinacijama, konfuzijom, ponašanjem sličnom psihotičnom, dezorijentacijom, agresivnim ponašanjem, agitacijom i delirijem.
English: If you still get problems with your skin because of the patch, please see ‘Skin problems caused by the patch' in section 4 for more information.
Croatian: Ako se unatoč svemu pojave promjene na koži uzrokovane flasterom, pogledajte odlomak 'Promjene na koži uzrokovane flasterom' u dijelu 4. za više informacija.
English: • swelling of legs and feet
Croatian: • otjecanje nogu i stopala
English: Restless Legs Syndrome
Croatian: Restless Legs Syndrome, RLS).
English: Peel off sachet in a cardboard carton: One side is composed of an ethylene copolymer (innermost layer), an aluminium foil, low density polyethylene film and paper; the other side is composed of polyethylene (innermost layer), aluminium, ethylene copolymer and paper.
Croatian: Zaštitna vrećica u kartonskoj kutiji: s jedne je strane napravljena od etilenskog kopolimera (unutarnji sloj), aluminijske folije, polietilenskog filma niske gustoće i papira; s druge strane od polietilena (unutarnji sloj), aluminija, etilenskog kopolimera i papira.
English: For doses higher than 8 mg/24 h (doses prescribed by your doctor above the available strengths), multiple patches must be applied to achieve the final dose.
Croatian: Za doze veće od 8 mg/24 h (doze koje je propisao Vaš liječnik a koje su iznad dostupnih jačina), morate primijeniti više flastera kako biste postigli konačnu dozu.
English: A dose reduction might be needed in case of worsening of the hepatic impairment.
Croatian: U slučaju pogoršanja oštećenja jetre može biti potrebno smanjenje doze.
English: Self adhesive matrix layer
Croatian: Samoljepljivi matriksni sloj
English: Augmentation may occur in Restless Legs Syndrome patients.
Croatian: Može se pojaviti augmentacija u bolesnika sa sindromom nemirnih nogu.
English: Co-administration of domperidone with rotigotine had no effect on the pharmacokinetics of rotigotine.
Croatian: Istodobna primjena domperidona s rotigotinom ne utječe na farmakokinetiku rotigotina.
English: Skin adhesion was measured on 2 consecutive days of 24 hours patch application.
Croatian: Prianjanje flastera na kožu mjereno je dva uzastopna dana s primjenom svakog flastera u trajanju od 24 sata.
English: Fold back the other half of the patch and remove the other side of the release liner.
Croatian: Odignite drugu stranu flastera i s nje odstranite zaštitni sloj.
English: The sticky side of the patch is covered by a transparent release liner.
Croatian: Na ljepljivoj strani flastera nalazi se prozirni zaštitni sloj.
English: The majority of application site reactions were mild or moderate in intensity, limited to the application areas and resulted in discontinuation of Leganto in 7.2% of subjects.
Croatian: Većina reakcija na mjestu primjene bila je blagog ili umjerenog intenziteta, ograničena na područja primjene, a 7,2% ispitanika zbog njih je prekinulo primjenu Leganta.
English: In the double blind study SP650DB, 113 patients received rotigotine up to a maximum dose of 8 mg/24 h, 109 patients received rotigotine up to a maximum dose of 12 mg/24 h and 119 patients received placebo.
Croatian: U dvostruko-slijepom ispitivanju SP650DB, 113 bolesnika primalo je rotigotin do najveće doze od 8 mg/24 h, 109 bolesnika primalo je rotigotin do najveće doze od 12 mg/24 h i 119 bolesnika primalo je placebo.
English: Co-administration of L-dopa and carbidopa with rotigotine had no effect on the pharmacokinetics of rotigotine, and rotigotine had no effect on the pharmacokinetics of L-dopa and carbidopa.
Croatian: Istodobna primjena levodope i karbidope s rotigotinom ne utječe na farmakokinetiku rotigotina, kao što ni rotigotin ne utječe na farmakokinetiku levodope i karbidope.
English: Transdermal patch rotigotine
Croatian: Transdermalni flaster rotigotin
English: • weight loss, weight increase
Croatian: • smanjenje tjelesne težine, povećanje tjelesne težine
English: The precise mechanism of action of rotigotine as a treatment of RLS is unknown.
Croatian: Točan mehanizam djelovanja rotigotina u liječenju sindroma nemirnih nogu nije poznat.
English: In a subsequent open-label study (SP824), a multicenter, multinational study, the tolerability of overnight switching from ropinirole, pramipexole or cabergoline to rotigotine transdermal patch and its effect on symptoms in subjects with idiopathic Parkinson's disease have been studied.
Croatian: U kasnijem otvorenom ispitivanju (SP824), multicentričnom, multinacionalnom ispitivanju ispitivana je podnošljivost zamjene ropinirola, pramipeksola ili kabergolina s transdermalnim flasterom rotigotina preko noći i njegov učinak na simptome u ispitanika s idiopatskom Parkinsonovom bolesti.
English: In the ropinirole group, patients were titrated to their optimal dose up to a maximum of 24 mg/day over 13 weeks.
Croatian: U ropinirol-skupini bolesnici su titrirani do optimalne doze od najviše 24 mg/dan kroz 13 tjedana.
English: The differences were statistically significant (p<0.001 and p=0.003, respectively).
Croatian: Razlike su bile statistički značajne (p<0,001, odnosno p=0,003).
English: Patients not taking levodopa - early stage of Parkinson's disease
Croatian: Bolesnici koji ne uzimaju levodopu - rana faza Parkinsonove bolesti
English: Other ingredients: Poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidoneK90, E171, E223, E304, E307, fluoropolymer, polyester, silicone, aluminium, pigments (yellow95, red166, red144, black7)
Croatian: Ostali sastojci: poli(dimetilsiloksan, trimetilsililsilikat)-kopolimerizat, povidon K90, E171, E223, E304, E307, fluoropolimer, poliester, silikon, aluminij, boje (žuta boja 95, crvena boja 166, crvena boja 144, crna boja 7)
English: Ophthalmologic monitoring
Croatian: Oftalmološki pregledi
English: Observed in patients with Restless Legs Syndrome
Croatian: Primjećeno u bolesnika sa sindromom nemirnih nogu
English: Tabulated list of adverse reactions
Croatian: Tabeliran popis nuspojava
English: • Poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidoneK90, sodium metabisulphite (E223), ascorbyl palmitate (E304) and DL-α-tocopherol (E307).
Croatian: • poli(dimetilsiloksan, trimetilsililsilikat)-kopolimerizat, povidon K90, natrijev metabisulfit (E223), askorbilpalmitat (E304) i DL--tokoferol (E307).
English: This effect was not confirmed in vivo in the Mouse Micronucleus Test in the rat Unscheduled DNA Synthesis (UDS) test.
Croatian: Takav učinak nije potvrđen in vivo u testu mikronukleusa miševa u UDS testu štakora (UDS - Unscheduled DNA Synthesis).
English: • redness, increased sweating
Croatian: • crvenilo, pojačano znojenje
English: Peel apart the foil.
Croatian: Odlijepite foliju.
English: For example, a daily dose of 14 mg may be reached by applying one patch of 6 mg/24 h and one patch of 8 mg/24 h and likewise, a daily dose of 16 mg can be reached by applying two patches of 8 mg/24 h.
Croatian: Primjerice, dnevnu dozu od 14 mg moguće je postići primjenom jednog flastera od 6 mg/24 h i jednog flastera od 8 mg/24 h i također, dnevnu dozu od 16 mg moguće je postići primjenom dva flastera od 8 mg/24 h.
English: • Press the patch down firmly with the palm of your hand.
Croatian: • Flaster čvrsto pritisnite dlanom.
English: The incidence of some dopaminergic adverse reactions, such as hallucinations, dyskinesia, and peripheral oedema generally is higher when given in combination with L-dopa in Parkinson's patients.
Croatian: Incidencija nekih dopaminergičkih nuspojava, kao što su halucinacije, diskinezija i periferni edemi, općenito je veća kod istovremene primjene s levodopom u bolesnika s Parkinsonovom bolešću.
English: If you are not sure about this, talk to your doctor, pharmacist or nurse first.
Croatian: Ako niste sigurni, najprije razgovarajte sa svojim liječnikom, ljekarnikom ili medicinskom sestrom.
English: • high blood pressure
Croatian: • povišen krvni tlak
English: Hypersensitivity, which may include angioedema, tongue oedema and lip oedema
Croatian: Poremećaji imunološkog sustava preosjetljivost, koja može uključivati angioedem, edem jezika i edem usnice
English: The following table covers adverse drug reactions from the pooled studies mentioned above in patients with Parkinson's disease and from post-marketing experience.
Croatian: Sljedeća tablica prikazuje nuspojave zabilježene u udruženim, prethodno spomenutim ispitivanjima u bolesnika s Parkinsonovom bolešću kao i nuspojave koje su se pojavile nakon stavljanja lijeka u promet.
English: • Do not use alcohol or other dissolving liquids - such as nail polish remover.
Croatian: • Nemojte koristiti alkohol ili druga otapala, kao što je odstranjivač laka za nokte, jer mogu nadražiti kožu.
English: Dialysis would not be expected to be beneficial as rotigotine is not eliminated by dialysis.
Croatian: Budući da se rotigotin ne eliminira dijalizom, ne očekuje se korist od dijalize.
English: Clinical studies in Parkinson's disease
Croatian: Klinička ispitivanja kod Parkinsonove bolesti
English: Atrial fibrillation Supraventricular tachycardia
Croatian: Srčani poremećaji palpitacije fibrilacija atrija supraventrikular na tahikardija
English: Because the patch is administered transdermally, no effect of food and gastrointestinal conditions is expected.
Croatian: Budući da se flaster primjenjuje transdermalno, ne očekuje se utjecaj hrane i stanja probavnog sustava na njegovu farmakokinetiku.
English: These symptoms are either reduced or their duration is shortened with Leganto treatment.
Croatian: Liječenje Legantom ublažava ove simptome ili skraćuje njihovo trajanje.
English: - If you have any further questions, ask your doctor or pharmacist.
Croatian: • Ako imate dodatnih pitanja, obratite se svom liječniku ili ljekarniku.
English: For doses higher than 8 mg/24 h multiple patches may be used to achieve the final dose e.g. 10 mg/24 h may be reached by combination of a 6 mg/24 h and a 4 mg/24 h patch.
Croatian: Za doze veće od 8 mg/24 h moguće je koristiti više flastera kako bi se postigla konačna doza, npr. 10 mg/24 h može se postići kombinacijom flastera s dozom 6 mg/24 h i 4 mg/24 h.
English: What Leganto is used for
Croatian: Za što se Leganto koristi
English: Rotigotine plasma concentrations increase dose-proportionally over a dose range of 1 mg/24 h to 24 mg/24 h.
Croatian: Koncentracije rotigotina u plazmi povećavaju se proporcionalno dozi u rasponu doza od 1 mg/24 h do 24 mg/24 h.
English: • generalised itching, skin irritation
Croatian: • generalizirani svrbež, nadraženost kože
English: CGI-I responder rates (much improved, very much improved) were 43.0% and 67.5% for placebo and rotigotine respectively (difference 24.5% CI 95%: 14.2%; 34.8%, p<0.0001).
Croatian: Stope bolesnika s odgovorom prema CGI-1 (dosta poboljšan, jako poboljšan) bile su 43,0% za placebo i 67,5% za rotigotin (razlika 24,5% CI95%: 14,2%; 34,8%, p<0,0001).
English: How to use the Leganto patches
Croatian: Kako koristiti Leganto flastere
English: If your doctor says you should stop Leganto, the daily dose of Leganto should be lowered gradually:
Croatian: Ako Vam liječnik kaže da trebate prestati koristiti Leganto, dnevnu dozu Leganta treba postupno smanjivati:
English: Multipack: 84 (3 packs of 28) transdermal patches
Croatian: OBLIK I SADRŽAJ Višestruko pakiranje: 84 (3 pakiranja od 28) transdermalna flastera
English: Transparent fluoropolymer coated polyester film.
Croatian: Poliesterski film obložen prozirnim fluoropolimerom.
English: • low blood pressure when standing up, high blood pressure
Croatian: • pad krvnog tlaka pri ustajanju, povišen krvni tlak
English: BOX OF 7 [28] [30] PATCHES
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA SA 7 [28] [30] FLASTERA
English: If a generalised skin reaction (e.g. allergic rash, including erythematous, macular, papular rash or pruritus) associated with the use of Leganto is observed, Leganto should be discontinued.
Croatian: Ako se javi generalizirana kožna reakcija (npr. alergijski osip uključujući eritematozni, makularni, papularni osip ili svrbež) zbog primjene Leganta, liječenje Neoprom treba prekinuti.
English: • Avoid sunlight and solarium exposure on areas of skin showing any kind of skin reaction caused by the patch.
Croatian: • Izbjegavajte izlaganje dijelova kože zahvaćenih bilo kakvom kožnom reakcijom uzrokovanom flasterom sunčevoj svjetlosti ili lampama u solariju.
English: Retinal degeneration was observed by transmission microscopy at a dose equivalent to 2.8 times the maximum recommended human dose on a mg/m² basis in a 3-month study in albino rats.
Croatian: U ispitivanju u trajanju od 3 mjeseca nakon primjene doze koja je bila 2,8 puta veća od najveće preporučene za ljude izražene u mg/m2, u albino štakora transmisijskim mikroskopom uočena je degeneracija retine.
English: The treatment initiation pack contains 28 transdermal patches in 4 cartons with 7 patches of 2 mg, 4 mg, 6 mg, and 8 mg each, individually sealed in sachets.
Croatian: Pakiranje za početak terapije sadrži 28 transdermalnih flastera u 4 kutije, svaka sa 7 flastera od 2 mg, 4 mg, 6 mg i 8 mg, zasebno pakiranih u vrećice.
English: • skin reactions under the patch such as redness and itching
Croatian: • kožna reakcija ispod flastera, kao što su crvenilo i svrbež
English: Poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, Povidone K90, sodium metabisulphite (E223), ascorbyl palmitate (E304) and
Croatian: Poli(dimetilsiloksan, trimetilsililsilikat)-kopolimerizat, povidon K90, natrijev metabisulfit (E223), askorbilpalmitat (E304) i
English: One treatment initiation pack contains 28 transdermal patches in 4 cartons with 7 patches of 2 mg, 4 mg, 6 mg, and 8 mg each, which are individually sealed in sachets.
Croatian: Jedno pakiranje za početak liječenja sadrži 28 transdermalnih flastera u 4 kutije, svaka sa 7 flastera od po 2 mg, 4 mg, 6 mg i 8 mg, zasebno pakiranih u vrećice.
English: • being aggressive
Croatian: • agresivnost