FrancophonIA/ELRC3.0 huggingface dataset:
English: For doses of exactly 100 mg amounts (100, 200, 300, 400, 500, or 600 mg) pour the entire content of each sachet over soft food (apple sauce or vanilla pudding) or mix with a small amount of liquid (water, chocolate milk, or infant formula) and consume entire serving.
Maltese: Għal dożi eżatti ta' ammonti ta' 100 mg (100, 200, 300, 400, 500, jew 600 mg) ferra il-kontenut kollu ta' kull qartas fuq ikel artab (zalza tat-tuffieħ jew pudina vanilla ) jew ħallat ma' ammont żgħir ta' likwidu (ilma, ħalib taċ-ċikkulata , jew formula għat-trabi ) u kkonsma l-porzjon kollu.
English: Clorazepate, diazepam, estazolam, flurazepam, oral and parenteral midazolam
Maltese: Clorazepate, diazepam, estazolam, flurazepam, midazolam mittieħed mill-ħalq u parenterali
English: HMG Co-A Reductase Inhibitors
Maltese: Impedituri HMG Co-A Reductase
English: (See section 4 Possible side effects)
Maltese: (ara sezzjoni 4.3).
English: Thyroid hormone replacement therapy
Maltese: Terapija ta' sostituzzjoni ta' ormon tattirojde
English: ↑ 20to39% ND
Maltese: Nelfinavir ↑ 20sa39% MD
English: ↑ 4.7-fold
Maltese: ↑ bi 4.7 drabi
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); not known (cannot be estimated from the available data).
Maltese: F'kull klassifikazzjoni ta' frekwenza, l-effetti mhux mixtieqa huma preżentati f'ordni li tibda mill-iktar effetti serji u tispiċċa fl-inqas effetti serji: komuni ħafna (≥ 1/10); komuni (≥ 1/100 sa < 1/10); mhux komuni (≥ 1/1000 sa < 1/100); rari (≥ 1/10,000 sa < 1/1,000); mhux magħrufa (ma jistgħux jiġu kkalkolati mill-informazzjoni eżistenti).
English: No subject experienced an increase in QTcF of ≥ 60 msec from baseline or a QTcF interval exceeding the potentially clinically relevant threshold of 500 msec.
Maltese: L-ebda suġġett ma ġarrab żieda fil-QTcF li hi  60 msec mil-linja bażi jew intervall QTcF li jeċċedi l-limitu li hu potenzjalment klinikament rilevanti ta' 500 msec.
English: If treatment with an HMGCoA reductase inhibitor is indicated, pravastatin or fluvastatin is recommended (see section 4.5).
Maltese: Jekk ikun indikat trattament b'impeditur HMG-CoA reductase, pravastatin jew fluvastatin huma rrakkomandati (ara sezzjoni 4.5).
English: Step 4.
Maltese: Stadju 4.
English: 600 q12h 2 h later
Maltese: 600 q12h 2 h wara
English: Common Anorexia, , flatulence, mouth ulcer, gastrointestinal haemorrhage, gastroesophageal reflux disease, pancreatitis
Maltese: Anoressija, gass fl-istonku, ulċera fil-ħalq, emorraġija gastrointestinali, mard tar-rifluss gastroesofagali, pankreatite
English: In an open label trial completed in 1998 in HIV infected, clinically stable children there was a significant difference (p = 0.03) in the detectable RNA levels in favour of a triple regimen (ritonavir, zidovudine and lamivudine) following 48 weeks treatment.
Maltese: Fi prova open label kompleta fl-1998 fuq tfal klinikament stabbli infettati bl-HIV, kien hemm, wara trattament ta' 48 ġimgħa, differenza sinifikanti (p = 0.03) fil-livelli traċċabbli ta' RNA favur dożaġġ triplu (ritonavir, zidovudine u lamivudine).
English: Twice Daily Dose 300 mg/m2
Maltese: Doża darbtejn kuljum 300 mg/m
English: • Draw up 9.4 ml of liquid using the provided oral dosing syringe, remove the bubbles, and transfer the liquid to the mixing cup.
Maltese: • Iġbed 9.4 mL ta' likwidu bl-użu ta' siringa pprovduta għall-dożaġġ orali, neħħi il-bżieżaq, u ttrasferixxi l-likwidu għall-tazza tat-taħlit.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000): not known (cannot be estimated from the available data).
Maltese: F'kull klassifikazzjoni ta' frekwenza, l-effetti mhux mixtieqa huma preżentati f'ordni li tibda mill-iktar effetti serji u tispiċċa fl-inqas effetti serji: komuni ħafna (≥ 1/10); komuni (≥ 1/100 sa < 1/10); mhux komuni (≥ 1/1000 sa < 1/100); rari (≥ 1/10,000 sa < 1/1,000): mhux magħrufa (ma jistgħux jiġu estimati minn informazzjoni li għandna).
English: For patients with renal impairment, a clarithromycin dose reduction should be considered: for patients with creatinine clearance of 30 to 60 ml/min the dose should be reduced by 50%, for patients with creatinine clearance less than 30 ml/min the dose should be reduced by 75%.
Maltese: Għal pazjenti li jbatu minn indeboliment renali għandu jiġi kkunsidrat tnaqqis fid-doża ta' clarithromycin: għal pazjenti li għandhom tneħħija tal-krejatina ta' minn 30 sa 60 ml/min id-doża għandha tiġi mnaqqsa b'50%, għal pazjenti li għandhom tneħħija tal-krejatina ta' inqas minn 30 ml/min id-doża għandha tiġi mnaqqsa b' 75%.
English: 50 µg, single dose 500 q12h
Maltese: 50 µg doża waħda 500 q12h
English: 50, oral single dose
Maltese: 50 doża waħda orali
English: - Hormonal contraceptives containing ethinyl oestradiol as Norvir may reduce the effectiveness of these medicines.
Maltese: - Kontraċettivi li fihom l-ormoni li fihom ethinyl oestradiol għax Norvir jista' jnaqqas leffettività ta' dawn il-mediċini.
English: 100, single oral dose 500 q12h ↑ 145% ↑ 22% The AUC and Cmax of the 2-hydroxy metabolite were decreased 15 and 67%, respectively.
Maltese: L-AUC u Cmax tal-metabolat 2-hydroxy ġew imnaqqsa b' 15 u 67%,
English: The isopropylthiazole oxidation metabolite (M-2) is the major metabolite and has antiviral activity similar to that of parent compound.
Maltese: Ilmetabolit ta' ossidifikazzjoni ta' isopropylthiazole (M-2) huwa l-metabolit prinċipali u għandhu attivita antiretrovirali simili għal dik tal-mediċina prinċipali (parent compound).
English: Norvir is a protease inhibitor used to control HIV infection.
Maltese: Norvir huwa impeditur protejaż użat biex jikkontrolla linfezzjoni tal-HIV.
English: Norvir 100 mg powder for oral suspension ritonavir
Maltese: Norvir 100 mg trab għal suspensjoni orali Ritonavir
English: Ritonavir is principally metabolised and eliminated by the liver.
Maltese: Ritonavir huwa prinċipalment metabolizzat u eliminat permezz tal-fwied.
English: Norvir should be started at 250 mg/m² and increased at 2 to 3 day intervals by 50 mg/m² twice daily (please refer to the Norvir 100 mg powder for oral suspension Summary of Product Characteristics).
Maltese: Norvir għandu jibda jittieħed b'doża ta' 250 mg/m² u jiżdied kull jumejn jew tlieta b'50 mg/m² darbtejn kuljum (jekk jogħġbok irreferi għas-Sommarju talKaratteristiċi tal-Prodott tas-soluzzjoni orali Norvir ta'100 mg trab għal suspensjoni orali).
English: Abnormal liver function tests, hepatitis (inflammation of the liver), and rarely jaundice, have been reported in patients taking Norvir.
Maltese: Testijiet abnormali tal-funzjoni tal-fwied, epatite (infjammazzjoni tal-fwied) u rarament is-suffejra, ġew rapportati f'pazjenti li jieħdu Norvir.
English: Due to the risk of QTc prolongation associated with DM-6705, if co-administration of delamanid with ritonavir is considered necessary, very frequent ECG monitoring throughout the full delamanid treatment period is recommended (see section 4.4 and refer to the delamanid Summary of Product Characteristics).
Maltese: Minħabba r-riskju ta' titwil tal-QTc assoċjati ma' DM 6705, jekk l-ko-amministrazzjoni ta' delamanid ma' ritonavir hija kkunsidrata neċessarja, huwa rrakkomandat monitoraġġ frekwenti ħafna ta' ECG matul il-perjodu kollu tat-trattament ta' delamanid (ara sezzjoni 4.4 u rreferi għas-Sommarju tal-Karatteristiċi tal-Prodott ta' delamanid).
English: Each tablet contains 100 mg ritonavir.
Maltese: Kull pillola fiha 100 mg ritonavir.
English: Norvir 100 mg powder for oral suspension
Maltese: Norvir 100 mg trab għal suspensjoni orali
English: 100, single dose 500 q12h
Maltese: 100,doża waħda 500 q12h
English: b. Each 0.2 ml is shown as a smaller line between the numbers.
Maltese: b. Kull 0.2 mL jintwera bħala linja iżgħar bejn in-numri.
English: ↑ 2.5 fold
Maltese: ↑bi 2.5 drabi
English: To calculate the volume to be administered (in ml) for intermediate body surface areas not included in the above table, the body surface area should be multiplied by a factor of: 25 for a dose of 250 mg/m²; 30 for 300 mg/m²; and 35 for 350 mg/m².
Maltese: Biex wieħed jikkalkula l-volum li għandu jingħata (f'ml), l-erja tas-superfiċje tal-ġisem għandha tiġi mmultiplikata b'fattur ta': 25 għal doża ta' 250 mg/m ²; 30 għal doża ta' 300 mg/m ²; u 35 għal doża ta'
English: Uncommon Diabetes mellitus Rare
Maltese: Mhux komuni Dijabete mellitus Rari
English: Tablet:
Maltese: Il-pillola:
English: Three pack sizes are available for Norvir tablets:
Maltese: Hawn tlett qisien ta' pakketti tal-pilloli Norvir li jistgħu jiġu akkwistati:
English: Based on cross-study comparison to 400 mg atazanavir once daily alone.
Maltese: 1.Ibbażat fuq studju komparattiv li jinqeleb ma' 400 mg atazanavir darba kuljum waħdu.
English: 50, single dose 200 q12h ↑ 2.4-fold An increase in the incidence in trazodone-related adverse reactions was noted when co-administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer.
Maltese: 50, doża waħda 200 q12h ↑ bi 2.4 drabi Meta trazodone ittieħed ma' ritonavir dożat bħala aġent antiretrovirali jew biex iżid l-effett farmakokinetiku, ġiet osservata żieda fl-inċidenza tarreazzjonijiet avversi relatati ma' trazodone.
English: Medicinal Product Interactions - Ritonavir with Protease Inhibitors
Maltese: Interazzjonijiet tal-prodott mediċinali - Ritonavir ma' Impedituri Protejaż
English: Sulfamethoxazole was co-administered with trimethoprim.
Maltese:  Sulfamethoxazole ingħata ma' trimethoprim.
English: In a clinical study investigating the interaction of rifampicin 600 mg once daily and saquinavir 1000 mg with ritonavir 100 mg twice daily in healthy volunteers, severe hepatocellular toxicity with transaminase elevations up to > 20-fold the upper limit of normal after 1 to 5 days of co-administration was noted.
Maltese: Fi studju kliniku li sar fuq voluntiera f'saħħithom fejn kienet qiegħda tiġi investigata l-interazzjoni ta' 600 mg rifampicin darba kuljum u 1000 mg saquinavir flimkien ma' 100 mg ritonavir darbtejn kuljum, wara li kienu għaddew minn ġurnata sa 5 ġranet ta' għoti tal-mediċini flimkien, ġiet innotata tossiċità epatoċellulari severa b'żidied fit-transaminase sa > 20-darba mill-ogħla limitu normali.
English: Twice Daily Dose 250 mg/m2
Maltese: Doża darbtejn kuljum 250 mg/m
English: Recommended doses of Norvir are:
Maltese: Id-dożi rrakkomandati ta' Norvir huma:
English: However, the AUC of the M-2 metabolite was approximately 3% of the AUC of parent compound.
Maltese: Iżda l-AUC talmetabolit M-2 kien bejn wieħed u ieħor 3% tal-AUC tal-mediċina prinċipali.
English: Effects on the Electrocardiogram
Maltese: Effetti fuq l-Elettrokardjogramm
English: Adult Use
Maltese: -Adulti
English: AbbVie Ltd Tel: +44 (0)1628 561090
Maltese: Tel: +44 (0)1628 561090
English: ↑ 49-fold
Maltese: ↑ b'49 darba
English: For details on preparation and administration of the Norvir powder for oral suspension, see section 6.6.
Maltese: Għaddettalji dwar il-preparazzjoni u l-metodu ta' kif għandu jingħata Norvir trab għal suspensjoni orali, irreferi għas-sezzjoni 6.6.
English: The mean changes from baseline in PR interval ranged from 11.0 to 24.0 msec in the 12 hour interval post dose.
Maltese: Fl-intervall ta' 12 -il siegħa wara li ngħatat id-doża, it-tibdil medju mil-linja bażi fl-intervall PR varja minn 11.0 sa 24.0 msec.
English: Serum concentrations may be increased due to P-glycoprotein, BCRP and OATP1B inhibition by ritonavir.
Maltese: Konċentrazzjonijiet fis-serum jistgħu jiżdiedu minħabba inibizzjoni ta' Pglycoprotein, BCRP u OATP1B minn ritonavir.
English: 3 mg/kg q8h 500 q12h ↓ 43% An increased dose of theophyline may be required when coadministered with ritonavir, due to induction of CYP1A2.
Maltese: 3 mg/kg q8h 500 q12h ↓ 43% Minħabba l-induzzjoni ta' CYP1A2, jista' jkun hemm bżonn ta' doża akbar ta' theophylline meta dan jittieħed flimkien ma' ritronavir.
English: ↑ 17-fold ND
Maltese: ↑ bi 17 -il darba
English: Medicinal
Maltese: KLINIKU
English: Administration with a high fat meal (917 kcal, 60% calories from fat) was associated with a mean decrease of 32 and 49% in ritonavir AUCinf and Cmax respectively, relative to fasting conditions.
Maltese: Għoti flimkien ma' ikla b'ħafna xaħam (917 kcal, 60% mix-xaħam) kien assoċjat ma' tnaqqis medju ta' 32 u 49% fl-AUCinf u Cmax rispettivament ta' ritonavir, relattiv għall-kundizzjonijiet ta' sawm.
English: In a study completed in 1996 recruiting less advanced HIV-1 infected patients (CD4 200-500 cells/µl) without previous antiretroviral therapy, ritonavir in combination with zidovudine or alone reduced viral load in plasma and increased CD4 count.
Maltese: Fi studju komplet fl-1996 li fih ħadu sehem pazjenti infettati bl-HIV pero fi stadju inqas avanzat talmarda (CD4 200-500 ċellula/l) u li ma kinux ingħataw terapija antiretrovirali qabel, ritonavir flimkien ma' zidovudine jew waħdu naqqas it-tagħbija virali fil-plażma u żid l-għadd ta' CD4.
English: • Pour the entire contents of 1 sachet (100 mg) into the mixing cup.
Maltese: • Ferra l-kontenut kollu ta' qartas wieħed (100 mg) fit-tazza għat-taħlit.
English: Sedatives/hynoptics
Maltese: Mediċina Sedattiva/ Ipnotika
English: The effects of ritonavir (alone or combined with other antiretroviral agents) on biological markers of disease activity such as CD4 cell count and viral RNA were evaluated in several studies involving HIV-1 infected patients.
Maltese: L-effetti ta' ritonavir (waħdu jew flimkien ma' aġenti antiretrovirali oħra) fuq werrejja bijoloġiċi talattività tal-mard, bħal għadd ta' ċelluli CD4 u RNA virali, ġew evalwati f'diversi studji li kienu jinvolvu pazjenti infettati bl-HIV-1.
English: Elevated norpethidine concentrations may increase the risk of CNS effects (e.g., seizures), see section 4.3.
Maltese: Konċentrazzjoni għolja ta' norpethidine jistgħu jżidu r-riskju tal-effetti tas-CNS (e.ż. attakki tal- epilessija), ara sezzjoni 4.3.
English: Norvir tablets are supplied in white high density polyethylene (HDPE) bottles closed with polypropylene caps.
Maltese: Il-pilloli Norvir huma fornuti fi fliexken bojod high density polyethylene (HDPE), magħluqa b'għotjin polyethylene.
English: Administering with liquid The entire contents of each sachet should be suspended in 9.4 ml of liquid (water, chocolate milk, or infant formula) giving a final concentration of 10 mg per ml.
Maltese: Il-kontenut kollu ta' kull qartas għandu jiġi sospiż f'9.4 mL ta' likwidu (ilma, ħalib taċċikkulata jew formula tat-trabi) li jagħti konċentrazzjoni finali ta' 10 mg kull ml.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING NORVIR FILM-COATED TABLETS - Multipack containing 90 (3 bottles of 30) film-coated tablets with blue box
Maltese: U KONTENUT Pakkett ta' aktar minn flixkun wieħed: 90 pillola miksija b'rita (3 fliexken ta' 30)
English: 438 mg (43.8 ml) twice daily
Maltese: 438 mg (43.8 ml) darbtejn kuljum
English: Ritonavir steady-state pharmacokinetic parameters were evaluated in HIV infected children above 2 years of age receiving doses ranging from 250 mg/m² twice daily to 400 mg/m² twice daily.
Maltese: Il-parametri farmakokinetiċi fissi ta' ritonavir ġew evalwati fi tfal infettati bl-HIV ta'eta ta' iżjed minn sentejn, li kienu qegħdin jirċievu dożi li jvarjaw minn 250 mg/m darbtejn kuljum għal 400 mg/m darbtejn kuljum.
English: In a study completed in 2000, 76 HIV-1 infected children aged 6 months to 12 years who were protease inhibitor naive and naive to lamivudine and/or stavudine received ritonavir 350 or 450 mg/m2 every 12 hours co-administered with lamivudine and stavudine.
Maltese: Fi studju komplet fl-2000, 76 tifel u tifla ta' eta ta' bejn 6 ġimgħat u 12 il-xagħar, li kienu infettati b'HIV-1 u li kienu naive għal inibituri protejaż u naive għal lamivudine u/jew stavudine, irċevew ritonavir 350 or 450 mg/m2 kull 12 il-siegħa mogħtija ma lamivudine u stavudine.
English: Ritonavir has a high affinity for several cytochrome P450 (CYP) isoforms and may inhibit oxidation with the following ranked order: CYP3A4 > CYP2D6.
Maltese: Ritonavir għandu affinita għolja għal diversi isoformi ta'ċitokromi P450 (CYP) u jista' jimpedixxi lossidazzjoni skond din l-ordni li ġejja:
English: In a study completed in 2003, 50 HIV-1 infected, protease inhibitor and lamivudine naïve children age 4 weeks to 2 years received ritonavir 350 or 450 mg/m2 every 12 hours co-administered with zidovudine 160 mg/m2 every 8 hours and lamivudine 4 mg/kg every 12 hours.
Maltese: Fi studju komplet fl-2003, 50 tifel u tifla ta' eta ta' bejn 4 ġimgħat u sentejn, li kienu infettati b'HIV-1 u qatt ma kienu esponew ruħom għal impedituri protejaż u lamivudine, kienu qegħdin jirċievu 350 jew 450 mg/m ritonavir kull 12 -il siegħa flimkien ma' 160 mg/m zidovudine kull 8 siegħat u 4 mg/kg lamivudine kull 12 -il siegħa.
English: • if Norvir is used to boost the effects of certain other anti-HIV medicines the typical dose for adults is 1 to 2 tablets once or twice daily.
Maltese: • jekk Norvir huwa użat biex iżid l-effetti ta' ċerti mediċini oħra għal kontra l-HIV, id-doża tipika għall-adulti hi minn 1 sa 2 pilloli darba jew darbtejn kuljum.
English: HCV Protease Inhibitor
Maltese: Impeditur tal-protejaż ta' HCV
English: Ritonavir co-administration is likely to result in increased plasma concentrations of amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, and quinidine and is therefore contraindicated (see section 4.3).
Maltese: It-teħid ta' ritonavir flimkien ma' amiodarone, bepridil, encainide, flecanide, propafenone u quinidine x'aktarx li jwassal għal żieda filkonċentrazzjoni fil-plażma ta' amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone u quinidine, u għalhekk huwa kontroindikat (ara sezzjoni 4.3).
English: In intent to treat analyses, 50% and 57% of patients in the 350 and 450 mg/m2 dose groups, respectively, achieved reduction in plasma HIV-1 RNA to ≤ 400 copies/ml at Week 48.
Maltese: Bl-intenzjoni li jiġu ttrattati analisi, 50% u 57% tal-pazjenti fil-gruppi dożati 350 and 450 mg/m rispettivament,
English: 526 mg (52.6 ml) twice daily
Maltese: 526 mg (52.6 ml) darbtejn kuljum
English: Dasatinib, nilotinib, vincristine, vinblastine Serum concentrations may be increased when co-administered with ritonavir resulting in the potential for increased incidence of adverse events.
Maltese: Dasatinib, nilotinib, vincristine, vinblastine Il-konċentrazzjonijiet tal-mediċina fis-serum jistgħu jiżdiedu meta dawn laġenti jittieħdu flimkien ma' ritonavir, b'konsegwenza li jkun hemm potenzjal ta' żieda fl-inċidenza ta' reazzjonijiet avversi.
English: Ritonavir steady-state pharmacokinetic parameters were evaluated in HIV infected children less than 2 years of age receiving doses ranging from 350 to 450 mg/m² twice daily.
Maltese: Il-parametri farmakokinetiċi fi stat fiss ta' ritonavir ġew evalwati fi tfal ta'eta ta' inqas minn sentejn infettati bl-HIV, li kienu qegħdin jirċievu dożi li jvarjaw minn 350 sa 450 mg/m² darbtejn kuljum.
English: Immunosupressants
Maltese: Mediċini Immuno-Suppressanti
English: ↓ 25% ND
Maltese: Ritonavir ↓ 40%
English: It is therefore important that you remain under the supervision of your doctor while taking Norvir.
Maltese: Hemm ċerti mediċini li inti assolutament ma tistax tieħu ma' Norvir.
English: Pancreatitis has been observed in patients receiving ritonavir therapy, including those who developed hypertriglyceridaemia.
Maltese: Il-pankreatite ġiet innutata f'pazjenti li kienu qegħdin jirċievu t-terapija b'Norvir, inkluż dawk li żviluppaw l-ipertrigliċeridemija.
English: Twice Daily Dose 350 mg/m2
Maltese: Doża darbtejn kuljum 350 mg/m
English: Ritonavir 100 mg twice daily with saquinavir 1000 mg twice daily provides saquinavir systemic exposure over 24 hours similar to or greater than those achieved with saquinavir 1200 mg three times daily without ritonavir.
Maltese: Saquinavir għandu jingħata biss flimkien ma' ritonavir. 100 mg ritonavir darbtejn kuljum flimkien ma' 1000 mg saquinavir darbtejn kuljum jipprovdu esponiment sistemiku fuq 24 siegħa li huwa simili jew ikbar minn dak li jirrizulta b'1200 mg saquinavir tliet darbiet kuljum, mingħajr ritonavir.
English: The concomitant use of tadalafil for the treatment of erectile dysfunction with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer should be with caution at reduced doses of no more than 10 mg tadalafil every 72 hours with increased monitoring for adverse reactions (see section 4.4).
Maltese: L-użu flimkien ta' tadalafil ma' ritonavir għat-trattament tal-problema talerezzjoni tal-pene dożat bħala aġent antiretrovirali jew biex iżid l-effett farmakokinetiku għandu jsir b'attenzjoni u b'dożi mnaqqsa ta' mhux aktar minn 10 mg tadalafil kull 72 siegħa, u għandu jkun hemm aktar osservazzjoni għal reazzjonijiet avversi (ara sezzjoni 4.4).
English: Life-threatening and fatal drug interactions have been reported in patients treated with colchicine and ritonavir (CYP3A4 and P-gp inhibition) in patients with renal and/or hepatic impairment (see sections 4.3 and 4.4).
Maltese: Ġew irrappurtati interazzjonijiet ma' prodotti mediċinali oħra, li jistgħu jipperikolaw il-ħajja u oħrajn fatali, f'pazjenti ttrattati b'colchicine u ritonavir (inibizzjoni ta' CYP3A u P-gp) f'pazjenti b'indeboliment renali u / jew epatiku (ara sezzjonijiet 4.3 u 4.4).
English: White, oval, debossed with [Abbott logo] and “NK”.
Maltese: Bajda, ovali, bil-[lowgo ta' Abbott] u “NK” imnaqqxa fiha..
English: Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3 - 4 fold increase in midazolam plasma levels.
Maltese: Informazzjoni li ħarġet mill-użu ta' midazolam perenterali flimkien ma' impedituri protejażi oħra tissuġġerixxi żieda fil-livelli fil-plażma ta' midazolam li tista' tkun possibilment 3-4 darbiet aktar.
English: Lovastatin, simvastatin Increased plasma concentrations of lovastatin and simvastatin; thereby, increasing the risk of myopathy including rhabdomyolysis (see section
Maltese: Lovastatin, simvastatin Żieda fil-konċentrazzjoni fil-plażma ta' lovastatin u simvastatin; għalhekk, dan iżid ir-riskju ta' mijopatija, li jinkludi rabdomijoli (ara sezzjoni
English: − antidepressants (e.g. amitriptyline, desipramine, fluoxetine, imipramine, nefazodone,
Maltese: (amprenavir, atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, saquinavir, tipranavir),
English: ↑ 13-fold
Maltese: Mard tal-Fwied
English: − Bosentan, riociguat (used for pulmonary arterial hypertension) as Norvir may increase the blood levels of this medicine.
Maltese: - Bosentan, riociguat (użat għal-pressjoni għolja fl-arterji pulmonari) għax Norvir jista' jżid illivelli ta' din il-mediċina fid-demm.
English: 750, single
Maltese: 750, doża waħda
English: Co-administration of bosentan and ritonavir may increase steady state bosentan maximum concentr ations (Cmax) and area under the curve (AUC).
Maltese: Amministrazzjoni ta' bosentan flimkien ma' ritonavir jista' jżid ilkonċentrazzjonijiet massimi (Cmax)ta' bosentan fl-istat fiss u l-erja ta' taħt il-kurva (AUC).
English: The concomitant administration with quetiapine is contraindicated (see section 4.5).
Maltese: Lamministrazzjoni flimkien ma' quetiapine huwa kontraindikat (ara sezzjoni 4.5).
English: Clinical trials confirmed the safety and efficacy of fosamprenavir 700 mg twice daily with ritonavir 100 mg twice daily.
Maltese: Provi kliniċi kkonfermaw is-sigurta u l-effikaċja ta' 700 mg fosamprenavir darbtejn kuljum ma' 100 mg ritonavir darbtejn kuljum.
English: Medicinal product interactions - Ritonavir with antiretroviral agents other than protease inhibitors
Maltese: Interazzjonijiet tal-prodotti mediċinali - Ritonavir ma' aġenti antiretrovirali minbarra impedituri protejaż
English: − antiviral medicine used to treat chronic hepatitis C virus (HCV) infection in adults (e.g.
Maltese: - mediċina ta' kontra t-tuberkolosi (bedaquiline u delamanid); - mediċina antivirali użata biex tittratta infezzjoni kronika mill-virus tal-epatite Ċ (HCV) f'adulti