FrancophonIA/ELRC3.0 huggingface dataset:
English: Animal reproduction studies have not been conducted with factor VIII, therefore no data are available on fertility.
Slovenian: Študij o vplivu faktorja VIII na sposobnost razmnoževanja pri živalih niso izvedli, zato podatkov glede plodnosti ni na voljo.
English: Patients should be advised to consult with their healthcare provider prior to travel.
Slovenian: Svetovati jim je treba, naj se pred potovanjem posvetujejo s svojim zdravstvenim delavcem.
English: In patients with existing cardiovascular risk factors, substitution therapy with factor VIII may increase the cardiovascular risk.
Slovenian: Pri bolnikih z obstoječimi srčno-žilnimi dejavniki tveganja lahko nadomestno zdravljenje z zdravilom s faktorjem VIII poveča srčno-žilno tveganje.
English: Discuss your intravenous infusion procedure with your doctor or other healthcare professional.
Slovenian: O postopku intravenskega infundiranja se pogovorite s svojim zdravnikom ali drugim zdravstvenim delavcem.
English: The data in the table below relates to PUP and PTP data from ReFacto AF studies in patients <12 years.
Slovenian: Podatki v spodnji preglednici se nanašajo na podatke o PUP in PTP iz študij zdravila ReFacto AF pri bolnikih, starih < 12 let.
English: The risk of developing inhibitors is correlated to the severity of the disease as well as the exposure to factor VIII, this risk being highest within the first 50 exposure days but continues throughout life although the risk is uncommon.
Slovenian: Tveganje za nastanek zaviralcev je odvisno od resnosti bolezni in izpostavljenosti faktorju VIII - največje je v prvih 50 dneh izpostavljenosti, vendar je prisotno vse življenje, čeprav je tveganje občasno.
English: Because of the rare occurrence of haemophilia A in women, experience regarding the use of factor VIII during pregnancy and breast-feeding is not available.
Slovenian: Ker je hemofilija A zelo redka pri ženskah, ni izkušenj o uporabi faktorja VIII med nosečnostjo in dojenjem.
English: - if your bleeding does not stop as expected and contact your doctor or seek immediate emergency care.
Slovenian: - če se krvavitev ne ustavi, tako kot ste pričakovali, obvestite svojega zdravnika ali poiščite nujno medicinsko pomoč.
English: This dose and duration will depend upon your individual needs for replacement factor VIII therapy.
Slovenian: Odmerek in trajanje zdravljenja sta odvisna od vaših potreb po nadomestnem zdravljenju s faktorjem VIII.
English: If any of these signs occur, stop the infusion immediately and contact a doctor or seek immediate emergency care.
Slovenian: Če se pojavi katerikoli od teh znakov, nemudoma prekinite infuzijo in obvestite zdravnika ali poiščite nujno medicinsko pomoč.
English: In a study of ReFacto, twenty of 113 (18%) previously treated patients (PTPs) had an increase in anti-CHO antibody titre, without any apparent clinical effect.
Slovenian: V študiji zdravila ReFacto je 20 od 113 (18 %) predhodno zdravljenih bolnikov (PTP - Previously Treated Patients) imelo zvišan titer protiteles anti-CHO brez vidnih kliničnih posledic.
English: No investigations on carcinogenic potential or toxicity to reproduction have been conducted.
Slovenian: Raziskav kancerogenega potenciala in vpliva na sposobnost razmnoževanja niso opravili.
English: - the formation of inhibitors (antibodies) is a known complication that can occur during treatment with all factor VIII medicines.
Slovenian: - nastanek zaviralcev (protiteles) je znan zaplet, ki se lahko pojavi med zdravljenjem z vsemi zdravili s faktorjem VIII.
English: PUPs <6 years
Slovenian: PUP < 6 let
English: Several began with OD infusions but switched to prophylaxis treatment during their participation, and some had only sporadic prophylaxis infusions.
Slovenian: Številni so začeli z infuzijami po potrebi, vendar so v času sodelovanja prešli na profilaktično zdravljenje, nekateri pa so prejemali le občasne profilaktične infuzije.
English: If your or your child's bleeding is not being controlled with ReFacto AF, tell your doctor immediately.
Slovenian: Če krvavitev pri vas ali vašem otroku z zdravilom ReFacto AF ni obvladana, morate to nemudoma povedati zdravniku;
English: At the end of this room temperature storage period, the product must not be put back in the refrigerator, but must be used or discarded.
Slovenian: Po koncu tega obdobja hranjenja pri sobni temperaturi zdravila ne smete spraviti nazaj v hladilnik, ampak ga morate porabiti ali zavreči.
English: Always wash your hands before performing the following procedures.
Slovenian: Pred izvajanjem spodaj navedenih postopkov si vedno umijte roke.
English: The frequencies are based on all causality treatment emergent adverse events in pooled clinical trials with 765 subjects.
Slovenian: Pogostnosti temeljijo na neželenih učinkih iz vseh vzrokov, ki so se pojavili med zdravljenjem v združenih kliničnih preskušanjih s 765 preskušanci.
English: Wipe the top of the vial with the alcohol swab provided, or use another antiseptic solution and allow to dry.
Slovenian: Obrišite vrh viale s priloženim alkoholnim zložencem (ali uporabite kakšno drugo antiseptično raztopino) in pustite, da se posuši.
English: Pharmacotherapeutic group: antihaemorrhagics, blood coagulation factor VIII; ATC code: B02BD02.
Slovenian: Farmakoterapevtska skupina: krvni koagulacijski faktorji, koagulacijski faktor VIII; oznaka ATC: B02BD02.
English: Moroctocog alfa is a glycoprotein with 1438 amino acids with a sequence that is comparable to the 90 + 80 kDa form of factor VIII (i.e. B-domain deleted) and similar post-translational modifications to those of the plasma-derived molecule.
Slovenian: Moroktokog alfa je glikoprotein s 1.438 aminokislinami z zaporedjem, ki je primerljivo obliki 90 + 80 kDa faktorja VIII (brez domene B), in s podobnimi post-translacijskimi spremembami kot v molekuli, ki izvira iz plazme.
English: Allergic reactions If severe, sudden allergic reactions (anaphylactic) occur, the infusion must be stopped immediately.
Slovenian: Če se pojavijo hude, nenadne alergijske (anafilaktične) reakcije, je treba infundiranje nemudoma prekiniti.
English: ReFacto AF is used for the treatment and prevention of bleeding (prophylaxis) in adults and children of all ages (including newborns) with haemophilia A.
Slovenian: Zdravilo ReFacto AF se uporablja za zdravljenje in preprečevanje krvavitev (profilakso) pri odraslih in otrocih vseh starosti (vključno z novorojenčki) s hemofilijo A.
English: What ReFacto AF is and what it is used for What you need to know before you use ReFacto AF How to use ReFacto AF
Slovenian: Kaj je zdravilo ReFacto AF in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo ReFacto AF Kako uporabljati zdravilo ReFacto AF Možni neželeni učinki
English: Activated factor VIII acts as a cofactor for activated factor IX, accelerating the conversion of factor X to activated factor X. Activated factor X converts prothrombin into thrombin.
Slovenian: Aktivirani faktor VIII je kofaktor pri aktivaciji faktorja IX, ki katalizira pretvorbo faktorja X v aktivirani faktor X. Slednji pretvori protrombin v trombin.
English: PTPs 6 to <12 years
Slovenian: PTP 6 do < 12 let
English: The clinical relevance of inhibitor development will depend on the titre of the inhibitor, with low titre posing less of a risk of insufficient clinical response than high titre inhibitors.
Slovenian: Klinični pomen nastanka zaviralcev je odvisen od titra zaviralca, pri čemer nizek titer pomeni manjše tveganje za nezadosten klinični odziv kot zaviralci z visokim titrom.
English: By replacement therapy, the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of the bleeding tendencies.
Slovenian: Z nadomestnim zdravljenjem se ravni faktorja VIII v plazmi povečajo in tako omogočijo začasno korekcijo pomanjkanja faktorja VIII in odpravijo nagnjenost k krvavitvam.
English: Known allergic reaction to hamster protein.
Slovenian: Znana alergijska reakcija na beljakovine hrčka.
English: Dose adjustment for patients with renal or hepatic impairment has not been studied in clinical trials.
Slovenian: Prilagajanje odmerkov bolnikom z okvaro ledvic ali jeter v kliničnih preskušanjih ni bilo raziskano.
English: PTPs <6 years
Slovenian: PTP < 6 let
English: Antibody test positive; Anti-factor VIII antibody test positive
Slovenian: Preiskave pozitiven test na protitelesa; pozitiven test na protitelesa proti faktorju VIII
English: Typically, one-stage clotting assay results are 20-50% lower than the chromogenic substrate assay results.
Slovenian: Rezultati enostopenjskega koagulacijskega preskusa so značilno 20-50 % manjši od rezultatov preskusa s kromogenim substratom.
English: b Patients aged 6 to <12 years only.
Slovenian: Samo bolniki, stari 6 do < 12 let.
English: The cap may need to be replaced (if not administering reconstituted ReFacto AF immediately), so set it aside by placing it on its top.
Slovenian: Včasih je treba pokrovček ponovno namestiti (če pripravljenega zdravila ReFacto AF ne uporabite takoj), zato ga odložite tako, da ga postavite z vrhnjo stranjo navzdol.
English: As part of the pivotal trial with ReFacto in PUPs, ITI data from 25 patients were reviewed (15 with high titres, 10 with low titres).
Slovenian: V sklopu ključnega preskušanja zdravila ReFacto pri PUP so ocenili podatke o ITI pri 25 bolnikih (15 z visokimi titri, 10 z nizkimi titri).
English: Out of 6 patients who developed low titre inhibitors but did not receive ITI, 5 had similar titre decreases.
Slovenian: Pri 5 od 6 bolnikov, ki so se jim razvili zaviralci z nizkim titrom in niso prejeli ITI, je prišlo do podobnega znižanja titrov.
English: What you need to know before you use ReFacto AF
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo ReFacto AF
English: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products, including other infusion solutions.
Slovenian: Zaradi pomanjkanja študij kompatibilnosti zdravila ne smemo mešati z drugimi zdravili, niti z drugimi raztopinami za infundiranje.
English: The dose and duration of the substitution therapy depend on the severity of the factor VIII deficiency, on the location and extent of bleeding, and on the patient's clinical condition.
Slovenian: Odmerki in trajanje zdravljenja so odvisni od stopnje pomanjkanja faktorja VIII, od mesta in obsega krvavitve in od bolnikovega kliničnega stanja.
English: In the case of the following haemorrhagic events, the factor VIII activity should not fall below the given plasma levels (in % of normal or in IU/dl) in the corresponding period.
Slovenian: V primeru naslednjih krvavitev aktivnost faktorja VIII ne sme pasti pod določene ravni (v % od normale ali v i.e./dl) v ustreznem času.
English: b Subjects in the PUP study were not required to follow a regular continuous prophylaxis treatment; however, with the exception of one subject (with only on demand (OD) treatment) the majority of subjects took regular prophylaxis infusions.
Slovenian: Preskušancem v študiji pri PUP ni bilo treba slediti rednemu, neprekinjenemu profilaktičnemu zdravljenju, vendar je z izjemo enega bolnika (ki se je zdravil samo po potrebi) večina bolnikov redno prejemala profilaktične infuzije.
English: Reports of lack of effect
Slovenian: Poročila o neučinkovitosti
English: Except in cases where inhibitors were detected, the mean recovery was stable over time (6 visits during a 2-year period) and individual values ranged from 0 (in presence of inhibitor) to 2.7 IU/dl per IU/kg.
Slovenian: Razen v primerih, kjer so zaznali zaviralce, je bilo povprečno zvečanje aktivnosti stabilno (6 obiskov v obdobju dveh let), posamezne vrednosti pa so bile v razponu od 0 (v prisotnosti zaviralcev) do 2,7 i.e./dl na i.e./kg.
English: Intravenous use, single use administration only.
Slovenian: za intravensko uporabo, samo za enkratno uporabo
English: Due to the difference in methods used to assign product potency of XYNTHA and ReFacto AF, 1 IU of the XYNTHA product (one-stage assay calibrated) is approximately equivalent to 1.38 IU of the ReFacto AF product (chromogenic assay calibrated).
Slovenian: Zaradi razlike v metodah, uporabljenih za določitev aktivnosti zdravil XYNTHA in ReFacto AF, ena i.e. zdravila XYNTHA (enostopenjski kalibrirani preskus) približno ustreza 1,38 i.e. zdravila ReFacto AF (kromogeni kalibrirani preskus).
English: After cleaning, do not touch the rubber stopper with your hand or allow it to touch any surface.
Slovenian: Ko gumijasti zamašek očistite, se ga ne smete več dotakniti z rokami; pazite tudi, da se ne dotakne ničesar drugega.
English: Consult with your health care provider before you travel.
Slovenian: Pred potovanjem se posvetujte s svojim zdravstvenim delavcem.
English: Required units (IU) = body weight (kg) x desired factor VIII rise (% or IU/dl) x 0.5 (IU/kg per IU/dl), where 0.5 IU/kg per IU/dl represents the reciprocal of the recovery generally observed following infusions of factor VIII.
Slovenian: Potrebno št. enot (i.e.) = telesna masa (kg) x želeno zvečanje aktivnosti faktorja VIII (% ali i.e./dl) x 0,5 (i.e./kg na i.e./dl), pri čemer 0,5 i.e./kg na i.e./dl pomeni recipročno vrednost zvečanja aktivnosti, ki ga na splošno opažamo po infuzijah faktorja VIII.
English: If this happens, your or your child's medicines may stop working properly and you or your child may experience persistent bleeding.
Slovenian: Če pride do tega, zdravilo pri vas ali vašem otroku ne bo več učinkovito in se lahko pojavi krvavitev, ki se ne ustavi.
English: Пфайзер Люксембург САРЛ, Клон България
Slovenian: Пфайзер Люксембург САРЛ, Клон България Тел.
English: Anaphylaxis is a severe allergic reaction that can cause difficulty in swallowing and/or breathing, red or swollen face and/or hands.
Slovenian: Anafilaksija je huda alergijska reakcija, ki lahko povzroča oteženo požiranje in/ali dihanje, pordečitev ali otekline obraza in/ali dlani.
English: One IU of factor VIII activity is equivalent to the quantity of factor VIII in one mL of normal human plasma.
Slovenian: Ena i.e. aktivnosti faktorja VIII ustreza količini faktorja VIII v enem ml normalne človeške plazme.
English: It is strongly recommended that every time ReFacto AF is administered to a patient, the name on the carton and batch number of the product are recorded in order to maintain a link between the patient and the batch number of the medicinal product.
Slovenian: Zelo priporočljivo je, da vsakič, ko bolnik prejme zdravilo ReFacto AF, zabeležite ime na škatli in številko serije zdravila, da ohranite povezavo med bolnikom in številko serije zdravila.
English: For the purposes of these instructions, this device will be referred to as a pre-filled syringe.
Slovenian: V teh navodilih je ta pripomoček poimenovan 'napolnjena injekcijska brizga'.
English: Another moroctocog alfa product approved for use outside Europe has a different manufacturing potency assigned that has been calibrated to the WHO International Standard using a one-stage clotting assay; this product is identified by the tradename XYNTHA.
Slovenian: Drugo zdravilo z moroktokogom alfa, odobreno za uporabo zunaj Evrope, ima drugačno proizvodno aktivnost, ki je bila kalibrirana na mednarodni standard SZO z enostopenjskim koagulacijskim preskusom; to zdravilo ima lastniško ime XYNTHA.
English: • inhibitor development for patients who have never been previously treated with factor VIII
Slovenian: • nastanek zaviralcev pri bolnikih, ki se niso nikoli prej zdravili z zdravili s faktorjem VIII
English: Haemophilia A is a sex-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII:C and results in profuse bleeding into joints, muscles or internal organs, either spontaneously or as a result of accidental or surgical trauma.
Slovenian: Hemofilija A je na spol vezana dedna bolezen strjevanja krvi, ki nastane zaradi zmanjšanja ravni faktorja VIII:C in se kaže v obliki krvavitev v sklepe, mišice ali notranje organe, bodisi spontane ali kot posledica poškodb ali operacij.
English: Factor VIII activity in plasma is expressed either as a percentage (relative to normal human plasma) or in IU (relative to an International Standard for factor VIII in plasma).
Slovenian: Aktivnost faktorja VIII v plazmi je izražena kot odstotek (glede na normalno človeško plazmo) ali v i.e. (glede na mednarodne standarde za faktor VIII v plazmi).
English: For long-term prophylaxis against bleeding in patients with severe haemophilia A, the usual doses are 20 to 40 IU of factor VIII per kg body weight at intervals of 2 to 3 days.
Slovenian: Za dolgotrajno profilaktično zdravljenje krvavitev pri bolnikih s hudo hemofilijo A so običajno potrebni odmerki 20 do 40 i.e. faktorja VIII na kg telesne mase vsaka 2 do 3 dni.
English: Dose based on bodyweight may require adjustment in underweight or overweight patients.
Slovenian: Odmerke, ki temeljijo na telesni masi, je pri bolnikih s premajhno ali preveliko telesno maso morda treba prilagoditi.
English: For reconstitution instructions prior to administration, see section 6.6.
Slovenian: Za navodila glede rekonstitucije zdravila pred dajanjem glejte poglavje 6.6.
English: Note: Please dispose of all unused solution, the empty pre-filled syringe, and the used medical supplies in an appropriate container for throwing away medical waste, as these materials may hurt others if not disposed of properly.
Slovenian: Opomba: Vso neuporabljeno raztopino, prazno napolnjeno injekcijsko brizgo in uporabljene medicinske pripomočke odložite v ustrezno posodo za odlaganje medicinskih odpadkov, saj lahko ti predmeti poškodujejo druge, če jih ne boste zavrgli na pravilen način.
English: • numbness, sleepiness, altered taste
Slovenian: • otrplost, zaspanost, spremenjeno okušanje
English: Treatment with ReFacto AF should be started by a doctor who is experienced in the care of patients with haemophilia A. Your doctor will decide the dose of ReFacto AF you will receive.
Slovenian: Zdravljenje z zdravilom ReFacto AF mora začeti zdravnik z izkušnjami pri skrbi za bolnike s hemofilijo A. Odmerek zdravila ReFacto AF vam bo določil zdravnik.
English: In case of shock, standard medical treatment for shock should be implemented.
Slovenian: V primeru šoka je treba upoštevati veljavne smernice za zdravljenje šoka.
English: Check with your doctor or pharmacist.
Slovenian: Posvetujte se z zdravnikom ali farmacevtom.
English: If you are not going to use the ReFacto AF solution immediately, you should store the syringe in an upright position, with the protective blue vented cap on the pre-filled syringe until you are ready to infuse.
Slovenian: Če raztopine zdravila ReFacto AF ne boste uporabili takoj, morate brizgo shraniti v pokončnem položaju, pri čemer mora biti na brizgi nameščena modra zaščitna zaporka z odprtinami, dokler ne boste pripravljeni za infundiranje zdravila.
English: Other medicines and ReFacto AF
Slovenian: Druga zdravila in zdravilo ReFacto AF
English: The calculation of the required dose of factor VIII is based upon the empirical finding that 1 IU of factor VIII per kg body weight raises the plasma factor VIII activity by 2 IU/dl.
Slovenian: Izračun potrebnega odmerka faktorja VIII temelji na empiričnih izkušnjah, da 1 i.e. faktorja VIII na kg telesne mase poveča aktivnost faktorja VIII v plazmi za 2 i.e./dl.
English: If you use more ReFacto AF than you should
Slovenian: Če ste uporabili večji odmerek zdravila ReFacto AF, kot bi smeli
English: Only the provided infusion set is to be used, because treatment failure can occur as a consequence of human-coagulation factor VIII adsorption to the internal surfaces of some infusion equipment.
Slovenian: Uporabljati smete le priloženi infuzijski sistem, ker je zaradi adsorpcije humanega koagulacijskega faktorja VIII na notranje površine nekaterih vrst infuzijske opreme možen neuspeh zdravljenja.
English: No interactions of recombinant coagulation factor VIII products with other medicinal products have been reported.
Slovenian: O medsebojnem delovanju zdravil z rekombinantnim koagulacijskim faktorjem VIII z drugimi zdravili niso poročali.
English: These patients (n=59; median age 10 ± 8.3 months) had a mean recovery at Week 0 of 1.5 ± 0.6 IU/dl per IU/kg (range 0.2 to 2.8 IU/dl per IU/kg) which was lower than that obtained in PTPs treated with ReFacto at Week 0 with a mean recovery of 2.4 ± 0.4 IU/dl per IU/kg (range 1.1 to 3.8 IU/dl per IU/kg).
Slovenian: Pri teh bolnikih (n = 59; mediana starost 10 ± 8,3 meseca) je bilo povprečno zvečanje aktivnosti v tednu 0 1,5  0,6 i.e./dl na i.e./kg (z razponom od 0,2 do 2,8 i.e./dl na i.e./kg); bilo je manjše kot tisto, ki so ga ugotovili pri PTP, zdravljenih z zdravilom ReFacto v tednu 0 s povprečnim zvečanjem aktivnosti 2,4 ± 0,4 i.e./dl na i.e./kg (razpon 1,1 do 3,8 i.e./dl na i.e./kg).
English: 5 How to store ReFacto AF Contents of the pack and other information
Slovenian: Shranjevanje zdravila ReFacto AF Vsebina pakiranja in dodatne informacije
English: Your doctor may change your recommended infusion rate to make the infusion more comfortable.
Slovenian: Zdravnik vam bo morda spremenil priporočeno hitrost infuzije, da se boste med infuzijo bolje počutili.
English: c Subjects in the PTP study reported their FVIII treatment modality (prophylaxis or on demand) at baseline and were not required to maintain this modality as a condition of study participation.
Slovenian: Preskušanci v študiji pri PTP so o načinu svojega zdravljenja s faktorjem VIII (profilaktično ali po potrebi) poročali ob izhodišču, vendar se jim tega načina ni bilo treba držati kot pogoj za sodelovanje v študiji.
English: Life-threatening haemorrhages
Slovenian: Življenjsko ogrožajoče krvavitve
English: • low blood pressure, pain and redness of veins associated with a blood clot, flushing
Slovenian: • nizek krvni tlak, bolečina in pordelost ven, ki sta povezani s krvnim strdkom, vročinski oblivi
English: Avoid touching the open end of the syringe or the protective blue vented cap.
Slovenian: Ne dotikajte se odprtega konca brizge ali zaščitne modre zaporke z odprtinami.
English: Pharmacokinetic parameter estimates for ReFacto in previously treated patients with haemophilia A
Slovenian: Ocene farmakokinetičnih parametrov za zdravilo ReFacto pri predhodno zdravljenih bolnikih s hemofilijo A
English: The reconstituted solution may be stored at room temperature for up to 3 hours.
Slovenian: Pripravljeno raztopino je mogoče shranjevati pri sobni temperaturi do 3 ure.
English: Safety of ReFacto AF was evaluated in studies that included both previously treated adults and previously treated children and adolescents (n=18, aged 12-16 years in a study and n=49, aged 7-16 years in a supporting study), with a tendency for higher frequencies of adverse reactions in children aged 7-16 years as compared to adults.
Slovenian: Varnost zdravila ReFacto AF so ovrednotili v študijah, ki so vključevale tako predhodno zdravljene odrasle kot predhodno zdravljene otroke in mladostnike (n = 18, stare 12-16 let v študiji in n = 49, stare 7-16 let v podporni študiji), pri čemer so bili otroci, stari 7-16 let, v primerjavi z odraslimi nagnjeni k večji pogostnosti neželenih učinkov.
English: Remove the contents of the ReFacto AF pre-filled syringe kit and place on a clean surface, making sure you have all the supplies you will need.
Slovenian: Vsebino kompleta zdravila ReFacto AF z napolnjeno injekcijsko brizgo vzemite iz ovojnine in jo položite na čisto površino, pri čemer se prepričajte, da imate vse pripomočke, ki jih boste potrebovali.
English: Some of the signs of allergic reactions are difficulty in breathing, shortness of breath, swelling, hives, itching, tightness of the chest, wheezing, and low blood pressure.
Slovenian: Nekateri znaki alergijskih reakcij so oteženo dihanje, kratka sapa, otekanje, koprivnica, srbenje, stiskanje v prsnem košu, piskajoče dihanje in znižan krvni tlak.
English: Reconstituted ReFacto AF must not be administered in the same tubing or container with other medicinal products.
Slovenian: Pripravljenega zdravila ReFacto AF se ne sme dajati po isti cevki ali ga v istem vsebniku mešati z drugimi zdravili.