FrancophonIA/ELRC3.0 huggingface dataset:
English: When diluted in glucose 50 mg/mL (5 %) solution for infusion, Ratiograstim is compatible with glass and a variety of plastics including PVC, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Slovenian: Če je razredčeno v raztopine glukoze 50 mg/ml (5 %) za infundiranje, je zdravilo Ratiograstim kompatibilno s steklom in vrsto plastičnih snovi, med katerimi so PVC, poliolefin (kopolimer polipropilena in polietilena) in polipropilen.
English: Sweets syndrome (acute febrile neutrophilic dermatosis)
Slovenian: Sweetov sindrom (akutna febrilna nevtrofilna dermatoza)
English: Ratiograstim is a solution for injection/infusion in a pre-filled syringe with or without safety device.
Slovenian: Zdravilo Ratiograstim je raztopina za injiciranje/infundiranje v napolnjeni injekcijski brizgi z varnostnim pripomočkom ali brez njega.
English: The safety and efficacy of filgrastim have not been assessed in normal donors < 16 years or > 60 years.
Slovenian: Varnosti in učinkovitosti uporabe filgrastima še niso ovrednotili pri zdravih darovalcih, mlajših od 16 let ali starejših od 60 let.
English: Other medicines and Ratiograstim
Slovenian: Druga zdravila in zdravilo Ratiograstim
English: • Inflammation of aorta (the large blood vessel which transports blood from the heart to the body), see section 2
Slovenian: • vnetje aorte (velike žile, ki prenaša kri od srca po telesu), glejte poglavje 2.
English: STATEMENT OF ACTIVE SUBSTANCE(S)
Slovenian: NAVEDBA ENE ALI VEČ ZDRAVILNIH UČINKOVIN (S)
English: There were no relevant differences between Ratiograstim and the reference product with regard to duration of severe neutropenia and incidence of febrile neutropenia.
Slovenian: Med zdravilom Ratiograstim in referenčnim zdravilom ni bilo očitne razlike v zvezi s trajanjem hude nevtropenije in nastanka febrilne nevtropenije.
English: White blood cell counts of 100 x 109/L or greater have been observed in less than 5 % of cancer patients receiving filgrastim at doses above 0.3 MIU/kg/day (3 μg/kg/day).
Slovenian: Levkocitoza Število belih krvničk 100 x 109/l ali več so ugotovili pri manj kot 5 % bolnikov z rakom, ki so prejemali filgrastim v odmerkih, večjih od 0,3 M i.e./kg/dan (3 μg/kg/dan).
English: The onset of pulmonary signs such as cough, fever and dyspnoea in association with radiological signs of pulmonary infiltrates and deterioration in pulmonary function may be preliminary signs of acute respiratory distress syndrome (ARDS).
Slovenian: Pojav pljučnih znakov, kot so kašelj, zvišana telesna temperatura in dispneja v povezavi z radiološkimi znaki pljučnih infiltratov in poslabšanjem pljučne funkcije, so lahko preliminarni znaki sindroma akutne dihalne stiske (ARDS - Acute Pulmonary Distress Syndrome).
English: • plum-coloured, raised, painful sores on the limbs and sometimes the face and neck with a fever (Sweets syndrome)
Slovenian: • boleče izbočene razjede slivnate barve na okončinah in včasih na obrazu in vratu, skupaj z vročino (Sweetov sindrom)
English: Thereafter, it is recommended that the ANC is measured at least twice weekly for the first two weeks and subsequently once per week or once every other week during maintenance therapy.
Slovenian: Priporočljivo je, da se v prvih 2 do 3 dneh zdravljenja s filgrastmom vsak dan meri vrednost ANC, pozneje pa je priporočljivo, da se ANC meri najmanj dvakrat na teden v prvih dveh tednih, potem pa enkrat na teden ali enkrat vsak drugi teden v času vzdrževalnega zdravljenja.
English: The long-term safety of filgrastim administration above 2.4 MIU (24 μg)/kg/day in patients with SCN has not been established.
Slovenian: Dolgoročna varnost odmerjanja filgrastima v odmerkih, večjih od 2,4 milijona i.e. (24 μg)/kg/dan, bolnikom s hudo kronično nevtropenijo, ni bila ugotovljena.
English: Contents of the pack and other information What Ratiograstim contains
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Ratiograstim
English: Ratiograstim is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 x 109/L) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate.
Slovenian: Zdravilo Ratiograstim se uporablja za zdravljenje dolgotrajne nevtropenije (ANC manjše ali enako 1,0 x 109/l ) pri bolnikih z napredovalo okužbo HIV, z namenom zmanjšanja tveganja bakterijskih okužb, ko druge oblike zdravljenja nevtropenije niso primerne.
English: Splenomegaly and Splenic rupture
Slovenian: Splenomegalija in ruptura vranice
English: If you forget to use Ratiograstim
Slovenian: Če ste pozabili uporabiti zdravilo Ratiograstim
English: Reversal of neutropenia or maintaining normal neutrophil counts: Filgrastim should be given by subcutaneous injection.
Slovenian: Odpravljanje nevtropenije ali ohranjanje normalnega števila nevtrofilcev: Filgrastim je treba dajati v obliki subkutane injekcije.
English: The no observed adverse effect level for embryo-foetal toxicity in this study was 10 µg/kg/day, which corresponded to a systemic exposure of approximately 3-5 times the exposures observed in patients treated with the clinical dose.
Slovenian: Raven brez opaženih neželenih učinkov v zvezi s toksičnostjo za zarodek/plod v tej študiji je bila 10 μg/kg/dan, kar je ustrezalo približno 3-5-krat večji sistemski izpostavljenosti kot jo opazimo pri bolnikih, ki so zdravljeni s kliničnimi odmerki.
English: Reduce to 0.5 MIU (5 µg)/kg/day
Slovenian: Zmanjšajte na 0,5 milijona i.e. (5 µg)/kg/dan
English: To give yourself a subcutaneous injection you will need: - a pre-filled syringe of Ratiograstim; - alcohol wipes or similar; - a puncture-proof container (plastic container provided by the hospital or pharmacy) so you can dispose of used syringes safely.
Slovenian: Za subkutano samoinjiciranje boste potrebovali: - napolnjeno injekcijsko brizgo z zdravilom Ratiograstim, - alkoholne krpice ali podobno, - vsebnik, odporen na vbode (plastičen vsebnik, ki ga dobite v bolnišnici ali lekarni), tako da boste lahko varno odlagali uporabljene brizge.
English: In view of the sensitivity of rapidly dividing myeloid cells to myelosuppressive cytotoxic chemotherapy, the use of filgrastim is not recommended in the period from 24 hours before to 24 hours after chemotherapy.
Slovenian: Zaradi občutljivosti hitro se delečih mieloidnih celic na mielosupresivno citotoksično kemoterapijo, 24 ur pred in 24 ur po kemoterapiji uporaba filgrastima ni priporočljiva.
English: What you need to know before you use Ratiograstim Do not use Ratiograstim
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Ratiograstim Ne uporabljajte zdravila Ratiograstim
English: • increase in white blood cells (leukocytosis)
Slovenian: • povečanje števila belih krvnih celic (levkocitoza)
English: Leukapheresis should be performed during the period when the ANC rises from < 0.5 x 109/L to > 5.0 x 109/L.
Slovenian: Levkafereze je potrebno izvesti v primeru, ko se absolutno število nevtrofilcev poveča iz < 0,5 x 109/l na > 5,0 x 109/l.
English: To give yourself a subcutaneous injection you will need: - a pre-filled syringe of Ratiograstim; - alcohol wipes or similar.
Slovenian: Za subkutano samoinjiciranje boste potrebovali: - napolnjeno injekcijsko brizgo z zdravilom Ratiograstim, - alkoholne krpice ali podobno,
English: If you use more Ratiograstim than you should, contact your doctor or pharmacist as soon as possible.
Slovenian: Če ste uporabili večji odmerek zdravila Ratiograstim, kot bi smeli, se čimprej posvetujte z zdravnikom ali farmacevtom.
English: Filgrastim should be administered daily by subcutaneous injection until the neutrophil count has reached and can be maintained at more than 1.5 x 109/L.
Slovenian: Filgrastim je potrebno odmerjati dnevno v obliki subkutanih injekcij, dokler število nevtrofilcev ne doseže in ostane večje od 1,5 x 109/l.
English: • high uric acid levels in the blood, which may cause gout (hyperuricaemia) (blood uric acid increased)
Slovenian: • povečane ravni sečne kisline v krvi, kar lahko povzroči putiko (hiperurikemija) (zvečanje vrednosti sečne kisline v krvi)
English: Ratiograstim is indicated for the mobilisation of peripheral blood progenitor cells (PBPC).
Slovenian: Zdravilo Ratiograstim se uporablja za izplavljanje krvotvornih matičnih celic v periferno kri (peripheral blood progenitor cells - PBPC).
English: Therefore, in patients with reduced precursors, neutrophil response may be diminished (such as those treated with extensive radiotherapy or chemotherapy, or those with bone marrow infiltration by tumour).
Slovenian: Zaradi tega lahko pri bolnikih z zmanjšanim številom prekurzorjev pride tudi do manjšega odziva nevtrofilcev (kot npr. pri bolnikih, ki prejemajo obsežno radioterapijo ali kemoterapijo, ali pri tistih, pri katerih je prišlo do tumorske infiltracije kostnega mozga).
English: Check the appearance of Ratiograstim.
Slovenian: Preverite videz raztopine Ratiograstima.
English: What Ratiograstim is and what it is used for What you need to know before you use Ratiograstim How to use Ratiograstim
Slovenian: Kaj je zdravilo Ratiograstim in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Ratiograstim Kako uporabljati zdravilo Ratiograstim
English: experience puffiness in your face or ankles, blood in your urine or brown-coloured urine or you notice you urinate less than usual (glomerulonephritis).
Slovenian: - opazite zabuhlost obraza ali gležnjev, kri v urinu ali rjavo obarvan urin, ali če opazite, da urinirate manj kot običajno (glomerulonefritis).
English: Use of filgrastim in patients with HIV infection maintains normal neutrophil counts to allow scheduled dosing of antiviral and/or other myelosuppressive medication.
Slovenian: Uporaba filgrastima pri bolnikih z okužbo HIV pomaga ohranjati število nevtrofilcev ter tako omogoča predvideno odmerjanje antivirusnih in/ali drugih mielosupresivnih zdravil.
English: During intermittent dosing with 30 MIU (300 μg)/day of filgrastim, there can be wide fluctuations in the patient's ANC over time.
Slovenian: Med intermitentnim odmerjanjem filgrastima po 30 M i.e. (300 µg)/dan so včasih opazna velika nihanja pri bolnikovih vrednostih ANC skozi čas.
English: A common side effect of Ratiograstim use is pain in your muscles or bones (musculoskeletal pain), which could be relieved by taking standard pain relief medicines (analgesics).
Slovenian: Pogost neželeni učinek uporabe zdravila Ratiograstim so bolečine v mišicah in kosteh (mišičnoskeletne bolečine), ki jih je mogoče lajšati s standardnimi protibolečinskimi zdravili (analgetiki).
English: Uncommon to < 1/100)
Slovenian: Pogosti (> 1/100 do
English: When the response has been obtained, the minimal effective dose to maintain this level should be established.
Slovenian: Ko je ta meja dosežena, je treba določi minimalen učinkovit odmerek, ki vzdržuje število nevtrofilcev na tej ravni.
English: Your doctor will tell you how long you will need to take Ratiograstim.
Slovenian: Zdravnik vam bo povedal, koliko časa morate jemati zdravilo Ratiograstim.
English: There have been reports of GvHD and fatalities in patients receiving G-CSF after allogeneic bone marrow transplantation (see section 4.4 and 5.1).
Slovenian: Obstajajo poročila o GvHD in o smrtnih primerih pri bolnikih, ki so prejemali G-CSF po alogenski presaditvi kostnega mozga (glejte poglavji 4.4 in 5.1).
English: Special precautions in recipients of allogeneic PBPCs mobilised with filgrastim
Slovenian: Posebni previdnostni ukrepi pri prejemnikih alogenskih PBPC, ki so bile izplavljene z uporabo filgrastima
English: Subcutaneous use and intravenous use.
Slovenian: subkutana in intravenska uporaba Samo za enkratno uporabo.
English: The safety and efficacy of filgrastim administration in patients with myelodysplastic syndrome or chronic myelogenous leukaemia have not been established.
Slovenian: Varnost in učinkovitost uporabe filgrastima pri bolnikih z mielodisplastičnim sindromom ali s kronično mieloično levkemijo še nista bili ugotovljeni.
English: Filgrastim acts primarily on neutrophil precursors to exert its effect in elevating neutrophil counts.
Slovenian: Filgrastim deluje v glavnem na prekurzorje za nevtrofilcev, kar vpliva na povišanje števila nevtrofilcev.
English: Filgrastim was studied in repeated dose toxicity studies up to 1 year in duration which revealed changes attributable to the expected pharmacological actions including increases in leukocytes, myeloid hyperplasia in bone marrow, extramedullary granulopoiesis and splenic enlargement.
Slovenian: Filgrastim so preučevali v konvencionalnih študijah toksičnosti pri ponavljajočih odmerkih, ki so trajale do 1 leta in pri katerih so razkrili spremembe, ki jih je bilo mogoče pripisati pričakovanim farmakološkim učinkom vključno z zvišanjem števila levkocitov, mieloidno hiperplazijo v kostnem mozgu, ekstramedularno granulocitopoezo in povečanjem vranice.
English: In cancer patients, the pharmacokinetic profile of Ratiograstim and the reference product was comparable after single and repeated subcutaneous administration.
Slovenian: Pri bolnikih z rakom sta bila farmakokinetična profila zdravila Ratiograstim in referenčnega zdravila primerljiva po enkratnem in ponavljajočem odmerku, ki so ga bolniki prejeli po subkutani poti.
English: Use of filgrastim, either alone or after chemotherapy, mobilises haematopoietic progenitor cells into peripheral blood.
Slovenian: Uporaba filgrastima, bodisi samostojno bodisi po kemoterapiji, spodbuja izplavljanje krvotvornih matičnih celic v periferni krvi.
English: Do not administer filgrastim to patients with a history of hypersensitivity to filgrastim or pegfilgrastim
Slovenian: Ne dajajte filgrastima bolnikom, ki imajo v anamnezi preobčutljivost na filgrastim ali pegfilgrastim.
English: Ratiograstim does not contain any preservative.
Slovenian: Zdravilo Ratiograstim ne vsebuje konzervansov.
English: Patients who have undergone very extensive prior myelosuppressive therapy may not show sufficient mobilisation of PBPC to achieve the recommended minimum yield (≥ 2.0 x 106 CD34+ cells/kg) or acceleration of platelet recovery to the same degree.
Slovenian: Pri bolnikih, ki so imeli zelo obsežno predhodno mielosupresivno zdravljenje, morda ne bo prišlo do zadostnega izplavljanja krvotvornih matičnih celic v periferno kri, da bi dosegli najmanjši priporočeni delež celic (≥ 2,0 milijona CD34+ celic/kg) oziroma pospešili povečevanje števila trombocitov v enaki meri.
English: In view of the possible risk of microbial contamination, Ratiograstim syringes are for single use only.
Slovenian: Ker obstaja tveganje mikrobne kontaminacije so z zdravilom Ratiograstim napolnjene brizge namenjene izključno enkratni uporabi.
English: You will normally receive your first dose of Ratiogratsim at least 24 hours after your chemotherapy and at least 24 hours after receiving your bone marrow transplant.
Slovenian: Običajno boste prvi odmerek zdravila Ratiograstim prejeli vsaj 24 ur po kemoterapiji in vsaj 24 ur po presaditvi kostnega mozga.
English: In a small number of patients (< 10 %), doses up to 1.0 MIU (10 μg)/kg/day were required to achieve reversal of neutropenia.
Slovenian: Pri manjšem številu bolnikov (manj od 10 %) so bili za ustavitev napredovanja nevtropenije potrebni odmerki do 1,0 milijon i.e. (10 μg)/kg/dan.
English: If leukocyte counts exceed 50 x 109/L after the expected nadir, filgrastim should be discontinued immediately.
Slovenian: Če po doseženem pričakovanem najnižjem številu levkocitov le-to potem preseže 50 x 109/l, je treba takoj prenehati z dajanjem filgrastima.
English: How is Ratiograstim given and much should I take?
Slovenian: Kako se daje zdravilo Ratiograstim in koliko ga moram vzeti?
English: Ratiograstim should not be diluted with sodium chloride solution.
Slovenian: Zdravila Ratiograstim ne smemo mešati z raztopino natrijevega klorida.
English: Some cytotoxic agents exhibit particular toxicities to the haematopoietic progenitor pool and may adversely affect progenitor mobilisation.
Slovenian: Nekatera citotoksična zdravila so še posebno toksična za krvotvorne matične celice in lahko negativno vplivajo na njihovo izplavljanje.
English: If you become pregnant during Ratiograstim treatment, please inform your doctor..
Slovenian: Če med zdravljenjem z zdravilom Ratiograstim zanosite, o tem obvestite svojega zdravnika.
English: Increased haematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient abnormal bone scans This should be considered when interpreting bone-imaging results.
Slovenian: Povečana hematopoetska aktivnost kostnega mozga kot odziv na zdravljenje z rastnim faktorjem je bila povezana s prehodno nenormalnimi izvidi slikanja kosti.
English: Congenital neutropenia
Slovenian: Odmerjanje Kongenitalna nevtropenija
English: The results of flow cytometric analysis of CD34+ cell numbers vary depending on the precise methodology used and recommendations of numbers based on studies in other laboratories need to be interpreted with caution.
Slovenian: s pretočno citometrijo se med seboj razlikujejo glede na dejansko uporabljeno metodologijo, zato je treba priporočila o številu celic, ki temeljijo na študijah v drugih laboratorijih, interpretirati previdno.
English: Ratiograstim is used to treat children who are receiving chemotherapy or who suffer from severe low white blood cell count (neutropenia).
Slovenian: Zdravilo Ratiograstim uporabljamo za zdravljenje otrok, ki prejemajo kemoterapijo ali ki imajo močno zmanjšano število belih krvničk (nevtropenija).
English: Accidental exposure to freezing temperatures does not adversely affect the stability of Ratiograstim.
Slovenian: Če je zdravilo Ratiograstim pomotoma izpostavljeno temperaturam pod lediščem, to ne škoduje njegovi stabilnosti.
English: Normal donors are given a dose of a 10 μg/kg/day, administered subcutaneously for 4 to 5 consecutive days.
Slovenian: Zdravi darovalci prejmejo odmerek 10 μg/kg/dan, ki se jim odmerja po subkutani poti 4 ali 5 dni zapored.
English: - if you have a combination of any of the following symptoms: - fever, or shivering, or feeling very cold, high heart rate, confusion or disorientation, shortness of breath, extreme pain or discomfort and clammy or sweaty skin.
Slovenian: - če se vam pojavi kombinacija katerihkoli izmed naslednjih neželenih učinkov: vročina ali drhtenje ali hudo mrazenje, hiter srčni utrip, zmedenost ali dezorientiranost, kratka sapa, izjemna bolečina ali nelagodje ter lepljiva ali znojna koža.
English: The effects of filgrastim on neutropenia due to bone marrow-infiltrating infection or malignancy have not been well established.
Slovenian: Učinki filgrastima na nevtropenijo, ki je posledica infiltracije kostnega mozga z okužbo ali malignim obolenjem, še niso dobro raziskani.
English: The stem cells will then go back into the bone marrow and produce blood cells.
Slovenian: Matične celice se vrnejo v kostni mozeg in tvorijo krvničke;
English: If required, Ratiograstim may be diluted in glucose 50 mg/mL (5 %) solution for infusion.
Slovenian: Če je potrebno, lahko zdravilo Ratiograstim razredčite v raztopini glukoze 50 mg/ml (5 %) za infundiranje.
English: As a result of the potential to receive higher doses or a greater number of these medicinal products with filgrastim therapy, the patient may be at higher risk of developing thrombocytopenia and anaemia.
Slovenian: Ker obstaja možnost, da bo bolnik ob zdravljenju s filgrastimom prejemal večje odmerke ali večje število teh zdravil, je lahko bolnik izpostavljen večjemu tveganju za nastanek trombocitopenije in anemije.
English: The recommended starting dose of filgrastim is 0.1 MIU (1 μg)/kg/day with titration up to a maximum of 0.4 MIU (4 μg)/kg/day until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 109/L).
Slovenian: Priporočeni začetni odmerek filgrastima je 0,1 milijona i.e. (1 μg)/kg/dan s povečanjem koncentracije na največ 0,4 x 106 i.e. (4 μg)/kg/dan, dokler število nevtrofilcev ne doseže in ne vzdržuje na običajni ravni (absolutno število nevtrofilcev večje od 2,0 x 109/l).
English: What Ratiograstim looks like and contents of the pack
Slovenian: Izgled zdravila Ratiograstim in vsebina pakiranja
English: These could be symptoms of condition called “capillary leak syndrome”, which causes blood to leak from the small blood vessels into your body and needs urgent medical attention.
Slovenian: To so lahko simptomi motnje, imenovane "sindrom kapilarne prepustnosti", ki povzroči puščanje krvi iz drobnih krvnih žilic v telesu, ki zahteva nujno zdravniško pomoč.
English: Leukocytosis (WBC > 50 x 109/l) was observed in 41% of normal donors and transient thrombocytopenia (platelets < 100 x 109/l) following filgrastim and leukapheresis was observed in 35% of donors (see section 4.4).
Slovenian: Levkocitozo (število belih krvničk > 50 x 109/l) so opazili pri 41 % zdravih darovalcev, prehodno trombocitopenijo (število trombocitov < 100 x 109/l) po prejemu filgrastima in levkaferezi pa pri 35 % darovalcev (glejte poglavje 4.4).
English: In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 x 109/L, and a history of severe or recurrent infections, long term administration of Ratiograstim is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.
Slovenian: Bolnikom, otrokom ali odraslim s hujšo obliko kongenitalne, ciklične ali idiopatične nevtropenije z absolutnim številom nevtrofilcev (ANC) ≤ 0,5 x 109/l in s hujšimi ali ponavljajočimi se okužbami, se dolgotrajno jemanje zdravila Ratiograstim predpiše zato, da se poveča število nevtrofilcev in zmanjša pogostost nastanka in trajanja z okužbami povezanih pojavov.
English: Mobilisation of PBPC does not provide a direct clinical benefit to normal donors and should only be considered for the purposes of allogeneic stem cell transplantation.
Slovenian: Izplavljanje krvotvornih matičnih celic v periferno kri nima neposrednih kliničnih koristi za zdrave darovalce, zato naj bi se uporabljalo samo pri alogenski presaditvi matičnih celic.
English: Ratiograstim containing r-metHuG-CSF (filgrastim) causes marked increases in peripheral blood neutrophil counts within 24 hours, with minor increases in monocytes.
Slovenian: Zdravilo Ratiograstim, ki vsebuje rekombinantni človeški G-CSF (filgrastim) v 24-ih urah povzroči izrazito zvišanje števila nevtrofilcev v periferni krvi, medtem ko je zvišanje monocitov manjše.
English: The recommended dose of filgrastim for PBPC mobilisation after myelosuppressive chemotherapy is 0.5 MIU (5 μg)/kg/day from the first day after completion of chemotherapy until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range.
Slovenian: Priporočen odmerek filgrastima za izplavljanje matičnih celic iz periferne krvi po mielosupresivni kemoterapiji je 0,5 x milijonov i.e. (5 μg)/kg/dan od prvega dne po koncu kemoterapije, pa dokler pričakovani padec števila nevtrofilcev ne preide na višji nivo in se število nevtrofilcev ne povrne na običajno raven.
English: - to increase the number of white blood cells if you suffer from severe chronic neutropenia to help prevent infections.
Slovenian: - za povečevanje števila belih krvničk, če imate hudo kronično nevtropenijo, kot pomoč pri preprečevanju okužb;
English: Preliminary evidence from a small number of patients treated concomitantly with filgrastim and 5-Fluorouracil indicates that the severity of neutropenia may be exacerbated.
Slovenian: Predhodni podatki, pridobljeni na podlagi opazovanj manjšega števila bolnikov, kažejo, da sočasna uporaba filgrastima in 5-fluorouracila okrepi nevtropenijo.