FrancophonIA/ELRC3.0 huggingface dataset:
English: Overall, the three dose levels of valsartan (low, medium and high) significantly reduced systolic blood pressure by 8, 10, 12 mmHg from the baseline, respectively.
Lithuanian: Apskritai visos trys valsartano doz s (maža, vidutin ir didel ) reikšmingai sumažino sistolin kraujosp d nuo pradinio rodmens (atitinkamai 8 mm Hg, 10 mm Hg ir 12 mm Hg).
English: • if you have severe kidney disease or if you are undergoing dialysis.
Lithuanian: • jeigu sergate sunkia inkst liga arba jeigu Jums atliekama dializ ;
English: o the usual dose is 40 mg of valsartan (corresponding to 13 ml of the solution).
Lithuanian: o prasta doz yra 40 mg valsartano (atitinka 13 ml tirpalo).
English: Screw the cap back on the bottle.
Lithuanian: Užsukite dangtel ant buteliuko.
English: CLINICAL PARTICULARS
Lithuanian: KLINIKIN INFORMACIJA
English: Before you drive a vehicle, use tools or operate machines, or carry out other activities that require concentration, make sure you know how Diovan affects you.
Lithuanian: Prieš vairavim , darb su prietaisais, mechanizm valdym ar kitok d mesio sukaupimo reikalaujant darb reikia pasitikrinti, koki reakcij sukelia Diovan.
English: In the second study, higher doses of valsartan were associated with greater BP reductions, but the dose response trend did not achieve statistical significance and the treatment difference compared to placebo was not significant.
Lithuanian: Antrojo tyrimo metu didesn s valsartano doz s buvo susijusios su didesniu kraujosp džio sumaž jimu, ta iau doz s ir reakcijos priklausomyb nebuvo statistiškai reikšminga, o gydomojo valsartano poveikio, palyginti su placebo, skirtumas buvo nereikšmingas.
English: • if you are allergic (hypersensitive) to valsartan or any of the other ingredients of Diovan listed at the end of this leaflet.
Lithuanian: • jeigu yra alergija (padid j s jautrumas) valsartanui arba bet kuriai pagalbinei Diovan medžiagai (jos išvardytos šio pakuot s lapelio pabaigoje);
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started.
Lithuanian: Nusta ius n štum , gydym AIIRA reikia nedelsiant nutraukti ir, jei reikia, prad ti alternatyv gydym .
English: The protocol of the study will be submitted by the applicant in the second quarter of 2010 for agreement with the CHMP with input from the PDCO.
Lithuanian: antr j ketvirt pareišk jas pateiks tyrimo protokol , kuris bus derinamas su CHMP, dalyvaujant Pediatrijos komitetui (PDCO).
English: PHARMACEUTICAL FORM Clear, colourless to pale yellow solution.
Lithuanian: FARMACIN FORMA Skaidrus, bespalvis ar šviesiais gelsvas tirpalas.
English: Valsartan is primarily eliminated by biliary excretion in faeces (about 83% of dose) and renally in urine (about 13% of dose), mainly as unchanged drug.
Lithuanian: valsartanas pirmiausia išsiskiria biliarin s ekskrecijos b du su išmatomis (apie 83 % doz s) ir per inkstus su šlapimu (apie 13 % doz s), daugiausiai nepakitusio preparato pavidalu.
English: Whilst there is no controlled epidemiological data on the risk with AIIRAs, similar risks may exist for this class of drugs.
Lithuanian: Nepaisant to, kad kontroliuojam j epidemiologini duomen apie AIIRA vartojim n ra, šios vaist grup s rizika gali b ti panaši.
English: 6.6 Special precautions for disposal
Lithuanian: 6.6 Special s reikalavimai atliekoms tvarkyti
English: • that consists of a clear plastic tube with a plunger inside.
Lithuanian: • J sudaro skaidraus plastiko vamzdelis su viduje esan iu st mokliu.
English: Consequently, a clinical relevance in children <1 year of age cannot be excluded, while preclinical data do not indicate a safety concern for children older than 1 year.
Lithuanian: Vadinasi, klinikins tokio poveikio reikšm s < 1 met vaikams paneigti negalima, ta iau ikiklinikiniai duomenys saugumo problem , galin i atsirasti vyresniems kaip 1 met vaikams, nerodo.
English: Not known
Lithuanian: Nežinoma
English: If any of these apply to you, tell your doctor before you take Diovan.
Lithuanian: Jei bent vienas iš ši teigini tinka Jums, prieš vartodami Diovan, apie tai praneškite gydytojui.
English: These measures will help to protect the environment.
Lithuanian: Šios priemon s pad s apsaugoti aplink .
English: Diovan is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Lithuanian: Diovan nerekomenduojama vartoti motinoms, kurios maitina kr timi, jei norite maitinti kr timi, J s gydytojas gali parinkti kit gydym , ypa tada, kai vaikas yra k tik gim s arba gim anks iau laiko.
English: o In the pharmacovigilance plan: Targeted checklists for follow up of adverse events listed above as potential risks in the paediatric population A study primarily aimed at establishing the long-term safety in CKD and non-CKD paediatric patients.
Lithuanian: o Farmakologinio budrumo plane: tiksliniai kontroliniai s rašai pirmiau išvardytiems galimiems pavojams vaik populiacijai steb ti; tyrimas, kuriuo vis pirma siekiama nustatyti ilgalaik preparato saugum l tine inkst liga sergantiems ir ja nesergantiems vaikams.
English: Instructions for using the oral syringe and the dosing cup
Lithuanian: Instrukcijos kaip naudoti geriam j švirkšt ir dozavimo taurel
English: Within each frequency grouping, adverse reactions are ranked in order of decreasing seriousness.
Lithuanian: Kiekvienoje dažnio grup je nepageidaujamos reakcijos pateikiamos maž jan io sunkumo tvarka.
English: The dose should be titrated based on blood pressure response and tolerability.
Lithuanian: Doz reikia titruoti atsižvelgiant kraujosp džio pokyt ir vaisto toleravim .
English: Do not stop taking your medicine unless your doctor tells you to.
Lithuanian: Nenutraukite vaisto vartojimo, jei tai padaryti nepatar gydytojas.
English: • The solution is supplied in a pack containing one 180 ml amber glass bottle with a childresistant screw cap and a yellow tamper evident ring.
Lithuanian: • Tirpalas tiekiamas pakuot je, kurioje yra 180 ml t rio gintaro spalvos stiklo buteliukas su vaik neatidaromu užsukamu dangteliu ir pažeidim rodan iu geltonu žiedu.
English: • If you have any further questions, ask your doctor or pharmacist.
Lithuanian: • Jeigu kilt daugiau klausim , kreipkit s gydytoj arba vaistinink .
English: The increased plasma levels of Ang II following AT1 receptor blockade with valsartan may stimulate the unblocked AT2 receptor, which appears to counterbalance the effect of the AT1 receptor.
Lithuanian: valsartanu užblokavus AT1 receptorius, kraujo plazmoje gali padaug ti angiotenzino II, kuris gali stimuliuoti neužblokuotus AT2 receptorius, taip sukeliamas priešingas poveikis nei pasireiškiantis, stimuliuojant AT1 receptorius.
English: An oral dosing syringe:
Lithuanian: Geriamasis dozavimo švirkštas:
English: Valsartan dose
Lithuanian: PAKUOT S LAPELIS
English: The amount of sucrose in the Diovan solution may be harmful to your teeth.
Lithuanian: Diovan tirpalo sud tyje esantis sacharoz s kiekis gali kenkti dantims.
English: Subsequently, frequent blood pressure monitoring should be performed taking into account potential under-dosing and dose should be titrated further based on blood pressure response and tolerability.
Lithuanian: Paskui reikia dažnai steb ti kraujosp d , atsižvelgiant galim nepakankamos doz s vartojim , o v liau doz reikia titruoti atsižvelgiant kraujosp džio pokyt ir vaisto toleravim .
English: POSSIBLE SIDE EFFECTS Like all medicines, Diovan can cause side effects, although not everybody gets them.
Lithuanian: Diovan, kaip ir kiti vaistai, gali sukelti šalutin poveik , nors jis pasireiškia ne visiems žmon ms.
English: Methyl parahydroxybenzoate (E218) Potassium sorbate
Lithuanian: Metilo parahidroksibenzoatas (E218) Kalio sorbatas
English: Valsartan is highly bound to serum proteins (94-97%), mainly serum albumin.
Lithuanian: Didelis kiekis, 9497 % valsartano jungiasi prie kraujo serumo baltym , daugiausiai albumin .
English: 180 ml amber type III glass bottle with a white child resistant polypropylene cap, including a polyethylene sealing disk and a yellow tamper evident ring, in addition the pack includes one dispensing kit containing one 5 ml oral dosing polypropylene syringe, one press in bottle adapter and one 30 ml polypropylene dosing cup.
Lithuanian: 180 ml t rio gintaro spalvos III tipo stiklo buteliukas su vaik neatidaromu polipropileno dangteliu, skaitant polietilenin sandarinimo disk ir pažeidim rodant gelton žied ; taip pat pakuot je yra vienas preparato ruošimo rinkinys, kur sudaro vienas 5 ml t rio polipropileno geriamasis dozavimo švirkštas, vienas buteliuk statomas adapteris ir viena 30 ml t rio polipropileno dozavimo taurel .
English: At 30 weeks, the percentage change in UAE was significantly reduced by 36% from baseline with valsartan 160 mg (95%CI: 22 to 47%), and by 44% with valsartan 320 mg (95%CI: 31 to 54%).
Lithuanian: Per 30 savai i procentinis AIŠ pokytis, lyginant su pradiniu, skiriant 160 mg valsartano, reikšmingai sumaž jo 36% (95 % PI: nuo 22 iki 47 %) ir 44 %, skiriant 320 mg valsartano (95% PI: nuo 31 iki 54%).
English: Following oral administration of valsartan alone, peak plasma concentrations of valsartan are reached in 2-4 hours with tablets and 1-2 hours with solution formulation.
Lithuanian: Išg rus vien tiktai valsartano, didžiausia vaisto koncentracija plazmoje pasiekiama per 2-4 valandas, jei vartojama table i , ir per 1-2 valandas, jei vartojama tirpalo.
English: Novartis Farma S.p.A. Largo Umberto Boccioni 1
Lithuanian: Largo Umberto Boccioni 1
English: For example, side effects such as dizziness, and decreased kidney function, were seen less frequently in adult patients treated with high blood pressure than in adult patients treated for heart failure or after a recent heart attack.
Lithuanian: Pavyzdžiui, tokios reakcijos kaip svaigimas, inkst funkcijos susilpn jimas buvo stebimos re iau tiems suaugusiesiems pacientams, kurie buvo gydomi d l aukšto kraujosp džio, nei tiems suaugusiesiems ligoniams, kurie buvo gydomi d l širdies nepakankamumo ar po neseniai vykusio širdies priepuolio.
English: Blood and lymphatic system disorders Not known
Lithuanian: Kraujo ir limfin s sistemos sutrikimai Nežinoma
English: • you must tell your doctor if you think you are (or might become) pregnant.
Lithuanian: • Pasakykite gydytojui, jei manote, kad pastojote (arba galb t pastojote).
English: The ADRs reported from clinical studies, post-marketing experience and laboratory findings are listed below according to system organ class.
Lithuanian: Klinikini tyrim metu, po vaisto patekimo rink ir atlikus laboratorinius tyrimus steb t NR s rašas pateikiamas toliau, pagal organ sistem klases.
English: In patients who continued to receive the medium and high doses of valsartan, systolic blood pressure at trough was -4 and -7 mm Hg lower than patients who received the placebo treatment.
Lithuanian: Ligoniams, kurie toliau vartojo vidutin ar didel valsartano doz , mažiausias sistolinis kraujosp dis buvo atitinkamai 4 mm Hg ir 7 mm Hg mažesnis nei placebo vartojusiems pacientams.
English: Novartis Farmacéutica, S.A. Gran Via de les Corts Catalanes,
Lithuanian: Gran Via de les Corts Catalanes,
English: • 1 ml oral solution contains 3 mg of valsartan.
Lithuanian: • 1 ml geriamojo tirpalo yra 3 mg valsartano.
English: 4.6 Fertility, pregnancy and lactation
Lithuanian: 4.6 Vaisingumas, n štumo ir žindymo laikotarpis
English: • if you are more than 3 months pregnant (it is also better to avoid Diovan in early pregnancy see pregnancy section).
Lithuanian: • jeigu esate n š ia daugiau kaip tris m nesius (taip pat geriau nevartoti Diovan ankstyvuoju n štumo laikotarpiu) arba kr timi maitinate k dik - žr.
English: PHARMACEUTICAL PARTICULARS
Lithuanian: FARMACIN INFORMACIJA
English: Clinical experience in children less than 6 years of age Two clinical studies were conducted in patients aged 1 to 6 years with 90 and 75 patients, respectively.
Lithuanian: Klinikin jaunesni kaip 6 met vaik gydymo patirtis Buvo atlikti du klinikiniai tyrimai su 1-6 met vaikais (viename dalyvavo 90 pacient , kitame 75 ligoniai).
English: In clinical trials where valsartan was compared with an ACE inhibitor, the incidence of dry cough was significantly (p<0.05) less in patients treated with valsartan than in those treated with an ACE inhibitor (2.6% versus 7.9% respectively).
Lithuanian: Klinikini tyrim metu valsartano poveikis buvo lyginamas su AKF inhibitori sukeliamu poveikiu, valsartanu gydomiems pacientams sausas kosulys pasireišk daug re iau (p < 0,05), negu gydomiems AKF inhibitoriais (atitinkamai 2,6 % ir 7,9 %).
English: In controlled clinical studies in adult patients with hypertension, the overall incidence of adverse reactions (ADRs) was comparable with placebo and is consistent with the pharmacology of valsartan.
Lithuanian: Su hipertenzija sergan iais suaugusiaisiais pacientais atlikt kontroliuojam j klinikini tyrim metu bendras nepageidaujam reakcij (NR) dažnis, lyginant su placebo grupe, buvo panašus ir atitiko valsartano farmakologines savybes.
English: The effect of the treatment can be influenced if Diovan is taken together with certain other medicines.
Lithuanian: Diovan vartojant kartu su tam tikrais kitais vaistais, tai gali tur ti takos gydymo efektui.
English: Diovan oral solution contains poloxamer (188) which may cause softened stools.
Lithuanian: Diovan geriamojo tirpalo sud tyje yra poloksamero (188), kuris gali minkštinti išmatas.
English: The Diovan Reduction of Proteinuria (DROP) study further examined the efficacy of valsartan in reducing UAE in 391 hypertensive patients (BP=150/88 mmHg) with type 2 diabetes, albuminuria (mean=102 µg/min; 20-700 µg/min) and preserved renal function (mean serum creatinine = 80 µmol/l).
Lithuanian: Diovan proteinurijos sumaž jimo tyrimo metu (Diovan Reduction of Proteinuria, DROP) buvo toliau tiriamas valsartano efektyvumas, mažinant AIŠ 391 hipertenzija sergantiems pacientams (AKS=150/88 mmHg), kurie papildomai sirgo 2 tipo diabetu, jiems pasireišk albuminurija (vidurkis=102 µg/min; 20-700 µg/min) ir buvo išsaugota inkst funkcija (vidutin kreatinino koncentracija serume = 80 µmol/l).
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION [To be completed nationally]
Lithuanian: RINKODAROS TEIS S SUTEIKIMO / ATNAUJINIMO DATA [Pildyti savo šalies kalba]
English: • other medicines that lower blood pressure, especially water tablets (diuretics).
Lithuanian: • kiti kraujosp d mažinantys vaistai, ypa šlapim varantys vaistai (diuretikai);
English: PHARMACEUTICAL FORM AND CONTENTS
Lithuanian: FARMACIN FORMA IR KIEKIS PAKUOT JE
English: The final study report should be submitted by the last quarter of 2010.
Lithuanian: Galutin tyrimo ataskaita bus parengta iki 2010 m.
English: Always take Diovan exactly as your doctor has told you in order to get the best results and reduce the risk of side effects.
Lithuanian: Diovan visada vartokite tiksliai, kaip nurod gydytojas, kad gydymo rezultatai b t geriausi ir sumaž t šalutinio poveikio rizika. Jeigu abejojate, kreipkit s gydytoj arba vaistinink .
English: Sit upright.
Lithuanian: Atsis skite tiesiai.
English: In hypertensive patients with type 2 diabetes and microalbuminuria, valsartan has been shown to reduce the urinary excretion of albumin.
Lithuanian: Hipertenzija ir 2 tipo diabetu sergantiems pacientams, kuriems pasireiškia mikroalbuminurija, vartojant valsartan sumaž ja albumino išsiskyrimas su šlapimu.
English: Renal failure and impairment, Elevation of serum creatinine General disorders and administration site conditions Uncommon
Lithuanian: Inkst nepakankamumas ir funkcijos sutrikimas, serumo kreatinino rodiklio padid jimas Bendrieji sutrikimai ir vartojimo vietos pažeidimai Nedažni
English: • Once opened, the bottle can be stored for up to 3 months at temperatures below 30°C.
Lithuanian: • Atidarius buteliuk , j galima laikyti iki 3 m nesi žemesn je kaip 30 °C temperat roje.
English: • increase of level of potassium in the blood (which can trigger muscle spasms and abnormal heart rhythm in severe cases)
Lithuanian: • kalio koncentracijos kraujyje padid jimas (tai sunkiais atvejais gali sukelti raumen spazmus ir sutrikdyti širdies ritm );
English: • Rinse the cup with clean water.
Lithuanian: • Išskalaukite taurel švariu vandeniu.
English: In most patients, after administration of a single oral dose, onset of antihypertensive activity occurs within 2 hours, and the peak reduction of blood pressure is achieved within 4-6 hours.
Lithuanian: Daugumai pacient vienkartin s doz s sukeliamas antihipertenzinis poveikis pasireiškia per 2 val., stipriausias kraujosp džio sumaž jimas pasiekiamas po 4-6 val.
English: In rats, maternally toxic doses (600 mg/kg/day) during the last days of gestation and lactation led to lower survival, lower weight gain and delayed development (pinna detachment and ear-canal opening) in the offspring (see section 4.6).
Lithuanian: Skiriant toksines dozes vaikingoms žiurk ms ( 600 mg/kg per par ) paskutin mis n štumo dienomis ir laktacijos metu, jaunikli išgyvenimas buvo mažesnis, jie priaugo mažiau svorio, j vystymasis buvo l tesnis (ausies kaušelio atsiskyrimas ir ausies kanalo atsidarymas) (žr.
English: • severely decreased kidney function (signs of acute renal failure)
Lithuanian: • labai susilpn jusi inkst funkcija ( maus inkst nepakankamumo požymiai);
English: Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however, a small increase in risk cannot be excluded.
Lithuanian: Teratogeniškumo, kuris pasireiškia d l AKF inhibitori poveikio pirmojo n štumo trimestro metu, galutini epidemiologini rodym negauta; ta iau negalima atmesti nedidelio rizikos padid jimo galimyb s.
English: Furthermore, concomitant use of angiotensin II antagonists and NSAIDs may lead to an increased risk of worsening of renal function and an increase in serum potassium.
Lithuanian: Be to, kartu vartojant angiotenzino II antagonistus ir NVNU, gali padid ti inkst funkcijos pablog jimo ir kalio koncentracijos padid jimo kraujo serume rizika.
English: For children who are unable to swallow tablets, the use of the Diovan oral solution up to 80 mg valsartan (corresponding to 27 ml) is recommended.
Lithuanian: Negalintiems nuryti table i vaikams rekomenduojama vartoti Diovan geriamojo tirpalo iki 80 mg valsartano doz s (atitinka 27 ml tirpalo).
English: 1 bottle containing 160 ml oral solution.
Lithuanian: 1 buteliukas, kuriame yra 160 ml geriamojo tirpalo.
English: High blood pressure increases the risk of heart attacks.
Lithuanian: Padid j s kraujosp dis didina miokardo infarkto rizik .
English: In some cases your doctor may ask you to take up to 80 mg of valsartan (corresponding to 27 ml of the solution).
Lithuanian: Kai kuriais atvejais J s gydytojas gali nurodyti Jums vartoti iki 80 mg valsartano (atitinka 27 ml tirpalo).
English: Therefore, if switching from Diovan tablets to Diovan oral solution is considered essential on clinical grounds, the valsartan dose should be adjusted as described in the table below and blood pressure should be carefully monitored.
Lithuanian: Tod l tais atvejais, kai laikoma, jog kliniškai b tina keisti gydym Diovan tablet mis Diovan geriam j tirpal , valsartano doz reikia koreguoti, kaip nurodyta toliau pateikiamoje lentel je, o kraujosp d reikia atidžiai steb ti.
English: Sodium and/or volume depletion should be corrected before starting treatment with Diovan, for example by reducing the diuretic dose.
Lithuanian: Prieš pradedant gydyti preparatu Diovan, reikia atstatyti normal natrio ir (arba) skys i kiek organizme, pvz., sumažinti diuretik doz .
English: Decrease in haemoglobin, Decrease in haematocrit, Neutropenia, Thrombocytopenia
Lithuanian: Hemoglobino rodiklio sumaž jimas, hematokrito rodiklio sumaž jimas, neutropenija, trombocitopenija
English: Patients were randomized to one of 3 doses of valsartan (160, 320 and 640 mg/od) and treated for 30 weeks.
Lithuanian: Pacientai atsitiktini im i b du buvo atrinkti grupes, kuriose buvo skiriama viena iš trij valsartano dozi (160, 320 ir 640 mg, skiriant vien kart per par ) ir gydoma 30 savai i .
English: As expected for a compound where renal clearance accounts for only 30% of total plasma clearance, no correlation was seen between renal function and systemic exposure to valsartan.
Lithuanian: Kaip ir tik tasi, vartojant valsartano, junginio, kurio klirensas inkstuose sudaro tik 30% bendro klirenso kraujo plazmoje, koreliacijos tarp sistemin s ekspozicijos ir inkst funkcijos nepasteb ta.
English: The frequency of some side effects may vary depending on your condition.
Lithuanian: Kai kuri šalutini reakcij dažnis gali b ti skirtingas, priklausomai nuo J s b kl s.
English: Patients were re-randomized to either continue receiving the same dose of valsartan or were switched to placebo.
Lithuanian: V liau pacientai iš naujo buvo suskirstyti atsitiktines imtis ir toliau vartojo toki pa i valsartano doz arba placebo.
English: Taking Diovan with food and drink You can take Diovan with or without food.
Lithuanian: Diovan vartojimas su maistu ir g rimais Diovan galima vartoti su maistu arba be jo.
English: • weakness
Lithuanian: • silpnumas.
English: Holding the open bottle upright on a table, push the bottle adapter firmly into the neck of the bottle as far as it will go.
Lithuanian: Laikykite atidaryt buteliuk vertikaliai ant stalo ir stipriai spauskite buteliuko adapter buteliuko kaklel kiek galima giliau.
English: Check that the plunger is pushed fully into the oral syringe.
Lithuanian: Patikrinkite, kad st moklis b t visiškai stumtas geriamojo švirkšto cilindr .
English: Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other agents that may increase potassium levels (heparin, etc.) is not recommended.
Lithuanian: Nerekomenduojama tuo pa iu metu vartoti kalio preparat , kal sulaikan i diuretik , druskos pakaital , kuri sud tyje yra kalio, arba kitoki preparat , kurie didina kalio kiek organizme (heparino ir kt.).
English: 5.2 Pharmacokinetic properties
Lithuanian: 5.2 Farmakokinetin s savyb s
English: • then, push the plunger all the way back in so that it is empty again.
Lithuanian: • tuomet stumkite st mokl atgal iki galo, kad geriamasis švirkštas v l ištušt t .
English: The antihypertensive effect of valsartan have been evaluated in four randomized, double-blind clinical studies in 561 paediatric patients from 6 to 18 years of age and 165 paediatric patients 1 to 6 years of age.
Lithuanian: Antihipertenzinis valsartano poveikis tirtas keturi klinikini atsitiktini im i dvigubai koduot tyrim , kuriuose dalyvavo 561 vaikas ir paauglys 6-18 met amžiaus bei 165 vaikai 1-6 met amžiaus.
English: Abrupt withdrawal of Diovan has not been associated with rebound hypertension or other adverse clinical events.
Lithuanian: Diovan vartojim nutraukus staiga, atoveiksmio hipertenzijos ar kitoki nepageidaujam reiškini neatsiranda.
English: 5.1 Pharmacodynamic properties
Lithuanian: 5.1 Farmakodinamin s savyb s
English: The MARVAL (Micro Albuminuria Reduction with Valsartan) study assessed the reduction in urinary albumin excretion (UAE) with valsartan (80-160 mg/od) versus amlodipine (5-10 mg/od), in 332 type 2 diabetic patients (mean age: 58 years; 265 men) with microalbuminuria (valsartan: 58 µg/min; amlodipine: 55.4 µg/min), normal or high blood pressure and with preserved renal function (blood creatinine <120 µmol/l).
Lithuanian: Micro Albuminuria Reduction with valsartan, „mikroalbuminurijos sumažinimo skiriant valsartan “) tyrimo metu buvo vertinamas albumino išsiskyrimas su šlapimu (AIŠ), skiriant valsartan (80-160 mg vien kart per par ) arba amlodipin (5-10 mg vien kart per par ) 332 antrojo tipo diabetu sergantiems pacientams (amžiaus vidurkis 58 metai; 265 vyrai), kuriems pasireišk mikroalbuminurija (valsartanas58 µg/min; amlodipinas - 55,4 µg/min), buvo normalus arba aukštas kraujosp dis ir išsaugota inkst funkcija (kreatininas kraujyje <120 µmol/l).