FrancophonIA/ELRC3.0 huggingface dataset:
English: The pressurised container is inserted in a polypropylene inhaler which incorporates a mouthpiece and a dose counter (60 actuations or 120 actuations per pressurised container) or dose indicator (180 actuations per pressurised container) and is provided with a polypropylene mouthpiece cap.
Croatian: Spremnik pod tlakom umetnut je u polipropilenski inhalator, koji ima nastavak za usta i brojač doza (60 potisaka ili 120 potisaka po spremniku pod tlakom) ili pokazivač doza (180 potisaka po spremniku pod tlakom) i opremljen je polipropilenskim zatvaračem nastavka za usta.
English: For beclometasone dipropionate, this results in a more potent effect than formulations with a non-extrafine particle size distribution (100 micrograms of beclometasone dipropionate extrafine in Riarify are equivalent to 250 micrograms of beclometasone dipropionate in a non-extrafine formulation).
Croatian: Posljedica toga je jači učinak beklometazondipropionata nego u formulacijama s distribucijom čestica čija veličina nije vrlo sitna (100 mikrograma beklometazondipropionata u vrlo sitnim česticama u lijeku Riarify odgovara 250 mikrograma beklometazondipropionata u formulaciji koja se ne raspršuje u vrlo sitne čestice).
English: The second major pathway involves O-demethylation followed by conjugation at the phenolic 2'-hydroxyl group.
Croatian: demetilaciju, nakon koje slijedi konjugacija na mjestu fenolne 2'-hidroksilne skupine.
English: • dry throat
Croatian: • suhoća grla
English: Riarify is a pressurised inhalation, solution.
Croatian: Riarify je stlačeni inhalat, otopina.
English: Fatigue1
Croatian: nazofaringitis1
English: Chemical and physical in-use stability has been demonstrated for 4 months at 25°C.
Croatian: Dokazano je da je lijek u primjeni kemijski i fizikalno stabilan 4 mjeseca na temperaturi od 25°C.
English: Anticholinergic agents like glycopyrronium could suppress lactation.
Croatian: Antikolinergici poput glikopironija mogu potisnuti stvaranje mlijeka.
English: Compared with tiotropium, Riarify also reduced the rate of severe exacerbations (i.e. excluding moderate exacerbations) by 32% (rate: 0.067 versus 0.098 events per patient/year; p = 0.017).
Croatian: U usporedbi s tiotropijem, Riarify je također smanjio stopu teških egzacerbacija (tj. isključujući umjerene egzacerbacije) za 32 % (stopa: 0,067 naspram 0,098 događaja po bolesniku godišnje; p = 0,017).
English: 180 actuations
Croatian: 180 potisaka
English: Compared with tiotropium, Riarify significantly improved IC by 39 mL (p = 0.025) and 60 mL (p = 0.001) after 26 and 52 weeks of treatment respectively.
Croatian: U usporedbi s tiotropijem,Riarify je značajno poboljšao inspiracijski kapacitet za 39 ml (p = 0,025) odnosno 60 ml (p = 0,001) nakon 26 odnosno 52 tjedna liječenja.
English: • fungal infections of the vagina
Croatian: • vaginalne gljivične infekcije
English: No differences were observed when comparing Riarify and the extemporary triple combination made of a fixed combination of beclometasone dipropionate and formoterol plus tiotropium (difference of 3 mL in pre-dose FEV1 after 52 weeks of treatment).
Croatian: Nisu bile opažene razlike kad se Riarify uspoređivao s ex tempore trostrukom fiksnom kombinacijom beklometazondipropionata i formoterola uz tiotropij (razlika od 3 ml u FEV1 prije doziranja nakon
English: In repeat dose inhalation studies with Riarify in rats and dogs of up to 13 weeks duration, the main observed alterations were related to effects on the immune system (probably due to systemic corticosteroid effects of beclometasone dipropionate and its active metabolite beclometasone17-monopropionate) and on the cardiovascular system (probably related to the beta2-adrenergic activity of formoterol and the anti-muscarinic activity of glycopyrronium).
Croatian: 13 tjedana glavne uočene promjene bile su povezane s učincima na imunosni sustav (vjerojatno zbog sistemskih kortikosteroidnih učinaka beklometazondipropionata i njegovog aktivnog metabolita beklometazon 17-monopropionata) i kardiovaskularni sustav (vjerojatno povezanima s beta-2
English: They should stop using the inhaler when the counter or indicator shows 0 as any puffs left in the device may not be enough to release a full actuation.
Croatian: Kada brojač ili pokazivač pokaže 0, trebaju prestati koristiti inhalator jer preostala količina u inhalatoru ne mora biti dovoljna za oslobađanje pune doze u potisku.
English: Pharmacotherapeutic group: Drugs for obstructive airway diseases, adrenergics in combination with anticholinergics incl.
Croatian: Farmakoterapijska skupina: lijekovi za opstruktivne bolesti dišnih putova, adrenergici u kombinaciji s antikolinergicima, uključujući trostruke kombinacije s kortikosteroidima.
English: Potentially serious hypokalaemia may result from beta2-agonist therapy.
Croatian: Terapija beta-2 agonistima može rezultirati potencijalno ozbiljnom hipokalijemijom.
English: Rash1, urticaria1, pruritus, hyperhidrosis1
Croatian: Poremećaji kože i potkožnog tkiva osip1, urtikarija1, pruritus, hiperhidroza1
English: Beclometasone dipropionate is a pro-drug with weak glucocorticoid receptor binding affinity that is hydrolysed via esterase enzymes to an active metabolite beclometasone 17-monopropionate which has a more potent topical anti-inflammatory activity compared with the pro-drug beclometasone dipropionate.
Croatian: Beklometazondipropionat je prolijek s niskim afinitetom vezanja za glukokortikoidne receptore, koji se hidrolizira putem enzima esteraza do djelatnog metabolita beklometazon 17-monopropionata, koji ima jače topikalno protuupalno djelovanje od prolijeka beklometazondipropionata.
English: Formoterol: hypokalaemia, hyperglycaemia, tremor, palpitations, muscle spasms, electrocardiogram QT prolonged, blood pressure increased, blood pressure decreased, atrial fibrillation, tachycardia, tachyarrhythmia, angina pectoris (stable and unstable), ventricular extrasystoles, nodal rhythm.
Croatian: elektrokardiografsko produljenje QT intervala, povišen krvni tlak, snižen krvni tlak, atrijska fibrilacija, tahikardija, tahiaritmija, angina pektoris (stabilna i nestabilna), ventrikularne ekstrasistole, nodalni ritam.
English: C-reactive protein increased1, platelet count increased1, free fatty acids increased1, blood insulin increased1, blood ketone body increased1, cortisol decreased1
Croatian: Pretrage povišen C-reaktivni protein1, povećan broj trombocita1, povišene slobodne masne kiseline1, povišena razina inzulina u krvi1, povišena razina ketonskih tijela u krvi1, snižen kortizol1
English: Compared with a fixed combination of indacaterol and glycopyrronium, Riarify improved average pre-dose FEV1 over the 52-week treatment period by 22 mL (p=0.018).
Croatian: usporedbi s fiksnom kombinacijom indakaterola i glikopironija, Riarify je poboljšao prosječni FEV1 prije doziranja tijekom razdoblja liječenja u trajanju od 52 tjedna za 22 ml (p = 0,018).
English: Beclometasone dipropionate/beclometasone-17-monopropionate was considered responsible for reproductive toxicity effects in rats such as reduction of the conception rate, fertility index, early embryonic development parameters (implantation loss), delay in ossification and increased incidence of visceral variations; while tocolytic and anti-muscarinic effects, attributed to the beta2-adrenergic activity of formoterol and the anti-muscarinic activity of glycopyrronium, affected pregnant rats in the late phase of gestation and/or early phase of lactation, leading to loss of pups.
Croatian: Smatra se da je beklometazondipropionat / beklometazon 17-monopropionat odgovoran za učinke reproduktivne toksičnosti poput smanjenja stope začeća, indeksa plodnosti, parametara ranog embrionalnog razvoja (implantacijski gubitak), kasne osifikacije i povećane incidencije varijacija unutarnjih organa u štakora; dok su se tokolitički i antimuskarinski učinci pripisani beta-2
English: • increased blood flow to some tissues in the body
Croatian: • pojačan protok krvi kroz neka tkiva u tijelu • kašalj i produktivni kašalj
English: • swallowing difficulties
Croatian: • otežano gutanje
English: • medicines for treating - abnormal heart rhythms (quinidine, disopyramide, procainamide), - allergic reactions (antihistamines), - symptoms of depression or mental disorders such as monoamine oxidase inhibitors (for example phenelzine and isocarboxazid), tricyclic antidepressants (for example amitriptyline and imipramine), phenothiazines can cause some changes in the electrocardiogram (ECG, heart trace).
Croatian: - simptoma depresije ili duševnih poremećaja kao što su inhibitori monoaminooksidaze (na primjer, fenelzin i izokarboksazid), triciklički antidepresivi (na primjer, amitriptilin i imipramin) i fenotiazini, koji mogu prouzročiti neke promjene u elektrokardiogramu (EKG-u).
English: Store at 25°C for a maximum of 4 months.
Croatian: Čuvati na temperaturi do 25°C najdulje 4 mjeseca.
English: Patients with severe hepatic impairment
Croatian: Bolesnici s teškim oštećenjem fukcije jetre
English: Compared with a fixed combination of beclometasone dipropionate and formoterol, Riarify significantly improved 2-hour post dose FEV1 by 117 mL after 26 weeks of treatment and by 103 mL after 52 weeks of treatment (p < 0.001).
Croatian: U usporedbi s fiksnom kombinacijom beklometazondipropionata i formoterola, Riarify je značajno poboljšao FEV1 dva sata poslije doziranja za 117 ml nakon 26 tjedana liječenja te za 103 ml nakon 52 tjedna liječenja (p < 0,001).
English: Store at 25°C for a maximum of 2 months.
Croatian: Čuvati na temperaturi do 25°C najdulje 2 mjeseca.
English: Study TRILOGY compared Riarify with a fixed combination of beclometasone dipropionate and formoterol 100/6 micrograms two inhalations twice daily (1,368 randomised patients).
Croatian: U ispitivanju TRILOGY, Riarify se uspoređivao s fiksnom kombinacijom beklometazondipropionata i formoterola 100/6 mikrograma primijenjenom u dva udaha dvaput na dan (1368 randomiziranih bolesnika).
English: Immediately after starting to breathe in, patients should firmly press down on the top of the pressurised container to release one puff.
Croatian: Odmah nakon početka udisaja, bolesnici trebaju čvrsto pritisnuti vrh spremnika pod tlakom prema dolje kako bi raspršili jednu dozu.
English: How to use your inhaler
Croatian: Kako se upotrebljava inhalator
English: The other ingredients are: ethanol anhydrous, hydrochloric acid, propellant: norflurane.
Croatian: Drugi sastojci su: etanol bezvodni, kloridna kiselina, potisni plin: norfluran.
English: Compared with tiotropium, Riarify improved pre-dose FEV1 by 51 mL after 26 weeks of treatment and by 61 mL after 52 weeks of treatment.
Croatian: usporedbi s tiotropijem, Riarify je poboljšao FEV1 prije doziranja za 51 ml nakon 26 tjedana liječenja i za 61 ml nakon 52 tjedna liječenja.
English: The active substances are: beclometasone dipropionate, formoterol fumarate dihydrate and glycopyrronium.
Croatian: Djelatne tvari su: beklometazondipropionat, formoterolfumarat dihidrat i glikopironij.
English: Each time you press the pressurised container, a puff of medicine is released and the dose indicator rotates by a small amount.
Croatian: Svaki put kad pritisnete spremnik pod tlakom, oslobodi se jedna raspršena doza lijeka i brojač pokaže jedan broj manje.
English: Just after starting to breathe in, press down firmly on the top of the pressurised container to release one puff.
Croatian: Neposredno nakon što počnete udisati, čvrsto pritisnite vrh spremnika pod tlakom prema dolje kako bi se oslobodila jedna raspršena doza.
English: A total of 3,346 patients were treated with beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium 87 micrograms/5 micrograms/9 micrograms at the target dose regimen (two inhalations twice daily) in multiple dose studies.
Croatian: U ispitivanjima višestrukih doza, ukupno je 3346 bolesnika bilo liječeno beklometazondipropionatom/formoterolfumarat dihidratom/glikopironijem 87 mikrograma/5 mikrograma/9 mikrograma prema ciljnom režimu doziranja (dva udaha dvaput na dan).
English: Pressurised inhalation, solution.
Croatian: Stlačeni inhalat, otopina.
English: Take care not to drop the inhaler as this may cause the counter to count down.
Croatian: Pazite da Vam inhalator ne ispadne jer to može prouzročiti odbrojavanje na pokazivaču.
English: For in-use storage conditions, see section 6.3.
Croatian: Uvjete čuvanja lijeka u primjeni vidjeti u dijelu 6.3.
English: 1 pressurised container of 120 actuations.
Croatian: 1 spremnik pod tlakom sa 120 potisaka.
English: Both studies were conducted in patients with a clinical diagnosis of COPD with severe to very severe airflow limitation (FEV1 less than 50% predicted), with symptoms assessed as a COPD Assessment Test (CAT) score of 10 or above, and with at least one COPD exacerbation in the previous year.
Croatian: Oba su ispitivanja provedena u bolesnika s kliničkom dijagnozom KOPB-a s teškim do vrlo teškim ograničenjem protoka zraka (FEV1 manji od 50 %
English: Remove the protective cap from the mouthpiece
Croatian: Uklonite zaštitni zatvarač s nastavka za usta
English: Testing your inhaler
Croatian: Isprobavanje inhalatora
English: • glycopyrronium.
Croatian: • glikopironij.
English: The total systemic exposure (as measured by AUC0-t) was slightly reduced for beclometasone 17-monopropionate (by 37%) and formoterol (by 24%), while it was increased for glycopyrronium (by 45%).
Croatian: (za 37 %) i formoterol (za 24 %), dok je za glikopironij bila povećana (za 45 %).
English: Chiesi Hellas AEBE Τηλ: + 30 210 6179763
Croatian: Τηλ: + 30 210 6179763
English: Blood and lymphatic system disorders
Croatian: Poremećaji krvi i limfnog sustava granulocitopenija1
English: Each pack contains one pressurised container either providing 60 puffs, 120 puffs or 180 puffs.
Croatian: Jedno pakiranje sadrži jedan spremnik pod tlakom sa 60, 120 ili 180 raspršenih doza.
English: Glycopyrronium: glaucoma, atrial fibrillation, tachycardia, palpitations, dry mouth, dental caries, dysuria, urinary retention, urinary tract infection.
Croatian: Glikopironijem: glaukom, atrijska fibrilacija, tahikardija, palpitacije, suha usta, zubni karijes, dizurija,
English: No differences were observed when comparing Riarify with the extemporary triple combination made of beclometasone dipropionate and formoterol fixed combination plus tiotropium (moderate/severe exacerbation rate: 0.46 versus 0.45 events per patient/year).
Croatian: Riarify uspoređivao s ex tempore trostrukom fiksnom kombinacijom beklometazondipropionata i formoterola uz tiotropij (stopa umjerenih/teških egzacerbacija: 0,46 naspram 0,45 događaja po bolesniku godišnje).
English: Excipients: anhydrous ethanol, hydrochloric acid; propellant: norflurane.
Croatian: Pomoćne tvari: bezvodni etanol, kloridna kiselina; potisni plin: norfluran.
English: For glycopyrronium, there was no impact in subjects with mild and moderate renal impairment.
Croatian: Nije bilo učinka na glikopironij u ispitanika s blagim i umjerenim oštećenjem bubrega.
English: 60 actuation pressurised container:
Croatian: Spremnik pod tlakom sa 60 potisaka:
English: Visual disturbance may be reported with systemic and topical corticosteroid use.
Croatian: Pri sistemskoj i topikalnoj uporabi kortikosteroida moguća je pojava poremećaja vida.
English: TRISTAR was a 26-week active-controlled open label study comparing Riarify with an extemporary combination made of a fixed combination of fluticasone/vilanterol 92/22 micrograms inhalation powder, one inhalation once daily plus tiotropium 18 micrograms inhalation powder, hard capsule, one inhalation once daily (1,157 randomised patients).
Croatian: TRISTAR je bilo aktivno kontrolirano otvoreno ispitivanje u trajanju od 26 tjedana u kojem se Riarify uspoređivao s ex tempore fiksnom kombinacijom flutikazona/vilanterola od 92/22 mikrograma u obliku praška inhalata, primijenjenom kao jedan udah jedanput na dan, u kombinaciji s tiotropijem od 18 mikrograma u obliku praška inhalata, u tvrdim kapsulama, primijenjenim kao jedan udah jedanput na dan (u 1157 randomiziranih bolesnika).
English: After dispensing, the medicinal product may be stored for a maximum of 4 months at a temperature up to 25°C.
Croatian: Nakon izdavanja, lijek se može čuvati najdulje 4 mjeseca na temperaturi do 25°C.
English: Hold the inhaler upright with the mouthpiece at the bottom and place the mouthpiece between your teeth without biting it. Then place your lips around the mouthpiece, with the tongue flat under it.
Croatian: Držite inhalator uspravno s nastavkom za usta dolje i postavite nastavak za usta između zuba, ali ga nemojte zagristi.
English: TRIBUTE was a 52-week activecontrolled study comparing Riarify with a fixed combination of indacaterol/glycopyrronium 85/43 micrograms inhalation powder, hard capsule, one inhalation once daily (1,532 randomised patients).
Croatian: TRIBUTE je bilo aktivno kontrolirano ispitivanje u trajanju od 52 tjedna u kojem se Riarify uspoređivao s fiksnom kombinacijom indakaterola/glikopironija od 85/43 mikrograma u obliku praška inhalata, u tvrdim kapsulama, primijenjenom kao jedan udah jedanput na dan (u 1532 randomizirana bolesnika).
English: After dispensing, the inhaler may be stored at a temperature up to 25°C for a maximum of 2 months.
Croatian: Nakon izdavanja, inhalator se može čuvati na temperaturi do 25°C najdulje 2 mjeseca.
English: • fungal infections of the chest
Croatian: • gljivične infekcije u prsnom košu
English: After dispensing, the medicinal product may be stored for a maximum of 2 months at a temperature up to 25°C.
Croatian: Nakon izdavanja, lijek se može čuvati najdulje 2 mjeseca na temperaturi do 25°C.
English: • beclometasone dipropionate,
Croatian: • beklometazondipropionat,
English: • palpitations (feeling of abnormal beating of the heart)
Croatian: • palpitacije (osjećaj nenormalnog lupanja srca) • crvenilo lica
English: 1 pressurised container of 60 actuations.
Croatian: 1 spremnik pod tlakom sa 60 potisaka.
English: Compared with a fixed combination of indacaterol and glycopyrronium, Riarify reduced the rate of moderate/severe exacerbations over 52 weeks by 15% (rate: 0.50 versus 0.59 events per patient/year; p = 0.043).
Croatian: U usporedbi s fiksnom kombinacijom indakaterola i glikopironija, Riarify je smanjio stopu umjerenih/teških egzacerbacija tijekom 52 tjedna za 15 % (stopa: 0,50 naspram 0,59 događaja po bolesniku godišnje; p = 0,043).
English: Diarrhoea1, dry mouth, dysphagia1, nausea, dyspepsia1, burning sensation of the lips1, dental caries1, (aphthous) stomatitis
Croatian: Poremećaji probavnog sustava proljev1, suha usta, disfagija1, mučnina, dispepsija1, osjećaj žarenja usana1, zubni karijes1, (aftozni) stomatitis manje često
English: • skin rash, hives, skin itching
Croatian: • kožni osip, koprivnjača, svrbež kože
English: The renal excretion of beclometasone dipropionate and its metabolites is negligible.
Croatian: Izlučivanje beklometazondipropionata i njegovih metabolita putem bubrega je zanemarivo.
English: Beclometasone dipropionate: pneumonia, oral fungal infections, lower respiratory tract infection fungal, dysphonia, throat irritation, hyperglycaemia, psychiatric disorders, cortisol decreased, blurred vision.
Croatian: Među opaženim nuspojavama, sljedeće se tipično povezuju s: Beklometazondipropionatom: pneumonija, oralne gljivične infekcije, gljivična infekcija donjih dišnih puteva, disfonija, nadraženost grla, hiperglikemija, psihijatrijski poremećaji, snižen kortizol, zamućen vid.
English: Pneumonia (in COPD patients), pharyngitis, oral candidiasis, urinary tract infection1, nasopharyngitis1
Croatian: Infekcije i infestacije pneumonija (u bolesnika s KOPB-om), faringitis, oralna kandidijaza, infekcija mokraćnog sustava1,
English: Similar effects were seen when comparing Riarify with the extemporary triple combination.
Croatian: Riarify uspoređivao s ex tempore trostrukom kombinacijom.
English: • increase in the level of some constituents of your blood: glucose, C-reactive protein,
Croatian: • povišenje razine nekih tvari u krvi: glukoze, C-reaktivnog proteina, broja krvnih pločica, inzulina, slobodnih masnih kiselina ili ketona.
English: Ethanol anhydrous Hydrochloric acid Norflurane (propellant)
Croatian: 6.1 Popis pomoćnih tvari etanol bezvodni kloridna kiselina norfluran (potisni plin)
English: Hypersomnia
Croatian: Hiperglikemija
English: 1 pressurised container of 180 actuations.
Croatian: 1 spremnik pod tlakom sa 180 potisaka.
English: • crushing chest pain
Croatian: • promuklost • glavobolja
English: Each delivered dose contains 87 micrograms of beclometasone dipropionate, 5 micrograms of formoterol fumarate dihydrate and 9 micrograms of glycopyrronium.
Croatian: Jedna isporučena doza sadrži 87 mikrograma beklometazondipropionata, 5 mikrograma formoterolfumarat dihidrata i 9 mikrograma glikopironija.
English: If you have or have had any medical problems or any allergies or if you are not sure if you can use Riarify, talk to your doctor or pharmacist before using the inhaler.
Croatian: Ako imate ili ste imali neke zdravstvene tegobe ili alergije ili niste sigurni smijete li primjenjivati
English: For the 180 actuation pressurised container, each time the patient presses the pressurised container a puff of the solution is released and the counter rotates by a small amount; the number of puffs remaining is displayed in intervals of 20.
Croatian: oslobodi se odmjerena doza raspršene otopine i brojač se malo zakrene; broj preostalih odmjerenih doza prikazuje se u intervalima od 20.
English: Compared with tiotropium, Riarify reduced the rate of moderate/severe exacerbations over 52 weeks by 20% (rate: 0.46 versus 0.57 events per patient/year; p = 0.003).
Croatian: U usporedbi s tiotropijem, Riarify je smanjio stopu umjerenih/teških egzacerbacija tijekom 52 tjedna za 20 % (stopa: 0,46 naspram 0,57 događaja po bolesniku godišnje; p = 0,003).
English: Riarify 87/5/9 micrograms pressurised inhalation, solution beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium
Croatian: Riarify 87/5/9 mikrograma stlačeni inhalat, otopina beklometazondipropionat/formoterolfumarat dihidrat/glikopironij
English: Immediate hypersensitivity reactions have been reported after administration of Riarify.
Croatian: Nakon primjene lijeka Riarify zabilježene su rane reakcije preosjetljivosti.
English: The mean elimination half-life of glycopyrronium in healthy volunteers was approximately 6 hours after i.v.
Croatian: Srednja vrijednost poluvijeka eliminacije glikopironija u zdravih dobrovoljaca iznosila je približno 6 sati nakon i.v. injekcije, dok je nakon inhalacije u bolesnika s KOPB-om iznosila 5 do 12 sati u stanju dinamičke ravnoteže.
English: Based on plasma concentrations measured following inhalation of a single 120 micrograms dose by 12 healthy subjects, the mean terminal elimination half-life was determined to be 10 hours.
Croatian: Na temelju koncentracija u plazmi izmjerenih u 12 zdravih ispitanika nakon inhalacije jedne doze od 120 mikrograma, izmjerena srednja vrijednost terminalnog poluvijeka eliminacije iznosi 10 sati. (R,R)- i (S,S)-enantiomeri činili su oko 40 % odnosno 60 % nepromijenjene djelatne tvari izlučene u mokraći.
English: Angioedema1
Croatian: manje često angioedem1
English: Reduction of COPD exacerbations
Croatian: Smanjenje egzacerbacija KOPB-a
English: Compared with a fixed combination of beclometasone dipropionate and formoterol, Riarify reduced the rate of moderate/severe exacerbations over 52 weeks by 23% (rate: 0.41 versus 0.53 events per patient/year; p = 0.005).
Croatian: U usporedbi s fiksnom kombinacijom beklometazondipropionata i formoterola, Riarify je smanjio stopu umjerenih/teških egzacerbacija tijekom 52 tjedna za 23 % (stopa: 0,41 naspram 0,53 događaja po bolesniku godišnje; p = 0,005).
English: Each delivered dose (the dose leaving the mouthpiece) contains 87 micrograms of beclometasone dipropionate, 5 micrograms of formoterol fumarate dihydrate and 9 micrograms of glycopyrronium (as 11 micrograms glycopyrronium bromide).
Croatian: Jedna isporučena doza (doza koja izađe iz nastavka za usta) sadrži 87 mikrograma beklometazondipropionata, 5 mikrograma formoterolfumarat dihidrata i 9 mikrograma glikopironija (u obliku 11 mikrograma glikopironijevog bromida).