FrancophonIA/ELRC3.0 huggingface dataset:
English: If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive Pemetrexed Fresenius Kabi.
Slovenian: Če imate ali ste imeli težave z ledvicami, se pogovorite z zdravnikom ali bolnišničnim farmacevtom, ker morda ne boste mogli prejeti zdravila Pemetreksed Fresenius Kabi.
English: Extravasation should be managed by local standard practice as with other nonvesicants.
Slovenian: Ob ekstravazaciji ukrepajte skladno z lokalno ustaljeno prakso kot pri drugih učinkovinah, ki niso mehurjevci.
English: *** Integrated adverse reactions table combines the results of the JMEN pemetrexed maintenance (N=663) and PARAMOUNT continuation pemetrexed maintenance (N=539) studies.
Slovenian: ***Skupna preglednica neželenih učinkov združuje rezultate študij vzdrževalnega zdravljenja samo s pemetreksedom JMEN (N = 663) in nadaljevalnega zdravljenja s pemetreksedom (PARAMOUNT: N = 539).
English: These differences were likely due to differences in the patient population, since the Phase 2 studies included both chemonaive and heavily pre-treated breast cancer patients with pre-existing liver metastases and/or abnormal baseline liver function tests.
Slovenian: Te razlike so bile verjetno posledica različnih populacij bolnikov, saj so v študijah faze 2 sodelovali bolniki, ki še niso prejemali kemoterapije, in tudi bolnice z rakom dojke, ki so v preteklosti prejemale kemoterapijo, s predhodno obstoječimi metastazami v jetrih in/ali nenormalnimi izhodiščnimi vrednostmi testov jetrnega delovanja.
English: Concomitant administration of substances that are also tubularly secreted (e.g. probenecid, penicillin) could potentially result in delayed clearance of pemetrexed.
Slovenian: Sočasno dajanje snovi, ki se tudi izločajo s tubulno sekrecijo (npr. probenecid, penicilin), lahko potencialno povzroči zakasnjeni očistek pemetrekseda.
English: Response (n: qualified for response) ▪ Response rate (%) (95% CI) ▪ Stable disease (%)
Slovenian: • RT (95 % IZ) Odziv (n: ustrezen za odziv) Stopnja odzivnosti (%) (95 % IZ) Stabilna bolezen (%)
English: For instructions on reconstitution and dilution of Pemetrexed Fresenius Kabi before administration, see section 6.6.
Slovenian: Za navodila glede rekonstitucije in redčenja zdravila Pemetreksed Fresenius Kabi pred dajanjem, glejte poglavje 6.6.
English: Patients receiving pemetrexed should be monitored before each dose with a complete blood count, including a differential white cell count (WCC) and platelet count.
Slovenian: Bolnikom, ki prejemajo pemetreksed, se mora pred vsakim odmerkom odvzeti kri za popolno krvno sliko, vključno z diferencialno belo krvno sliko (WCC - white cell count) in številom trombocitov.
English: ▪ If you experience sudden breathlessness, intense chest pain or cough with bloody sputum (uncommon) (may indicate a blood clot in the blood vessels of the lungs)
Slovenian: • Če doživite nenadno težko dihanje, močno bolečino v prsih ali kašelj s krvavim izmečkom (občasno) (lahko kaže na krvni strdek v krvnih žilah v pljučih).
English: The other ingredients are mannitol, hydrochloric acid concentrated and trometamol.
Slovenian: Druge sestavine zdravila so manitol, koncentrirana klorovodikova kislina in trometamol.
English: Therefore, caution should be made when administering higher doses of NSAIDs or acetylsalicylic acid, concurrently with pemetrexed to patients with normal function (creatinine clearance > 80 ml/min).
Slovenian: Zato je pri dajanju visokih odmerkov NSAIDs ali acetilsalicilne kisline sočasno s pemetreksedom bolnikom z normalnim delovanjem ledvic (očistek kreatinina ≥ 80 ml/min) potrebna previdnost.
English: These criteria meet the National Cancer Institute Common Toxicity Criteria (CTC v2.0; NCI 1998) definition of ≥CTC Grade 2 bleeding.
Slovenian: Ta merila ustrezajo Merilom pogostih toksičnosti Nacionalnega inštituta za rakava obolenja (National Cancer Institute Common Toxicity Criteria, CTC v2.0; NCI 1998), definiciji za ≥ CTC stopnjo krvavitve 2.
English: Cisplatin is also given by infusion into one of your veins, and is given approximately 30 minutes after the infusion of Pemetrexed Fresenius Kabi has finished.
Slovenian: Cisplatin tudi dajemo v obliki infuzije v veno, približno 30 minut po zaključku infuzije zdravila Pemetreksed Fresenius Kabi.
English: ▪ If you have pain, redness, swelling or sores in your mouth (very common).
Slovenian: • Če imate bolečino, rdečino, oteklino ali razjede v ustni votlini (zelo pogosto).
English: Abbreviation: CI = confidence interval * p-value refers to comparison between arms.
Slovenian: Okrajšava: IZ = interval zaupanja * p-vrednost se nanaša na primerjavo med vejama zdravljenja.
English: Any unused medicinal product or waste material must be disposed of in accordance with local requirements.
Slovenian: Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi zahtevami.
English: What Pemetrexed Fresenius Kabi is and what it is used for What you need to know before you use Pemetrexed Fresenius Kabi How to use Pemetrexed Fresenius Kabi Possible side effects
Slovenian: Kaj je zdravilo Pemetreksed Fresenius Kabi in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Pemetreksed Fresenius Kabi Kako uporabljati zdravilo Pemetreksed Fresenius Kabi Možni neželeni učinki
English: Other undesirable effects include renal toxicities, increased aminotransferases, alopecia, fatigue, dehydration, rash, infection/sepsis and neuropathy.
Slovenian: Drugi neželeni učinki vključujejo toksičnost za ledvice, povišane vrednosti aminotransferaze, alopecijo, utrujenost, dehidracijo, izpuščaj, okužbo/sepso in nevropatijo.
English: If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), Pemetrexed Fresenius Kabi should be withheld until resolution to less than or equal to the patient's pre-therapy value.
Slovenian: Če se pri bolnikih razvijejo nehematološke toksičnosti ≥ stopnje 3 (z izjemo nevrološke toksičnosti), se dajanje zdravila Pemetreksed Fresenius Kabi prekine, dokler se vrednosti ne povrnejo na manjše ali enake, kot jih je imel bolnik pred zdravljenjem.
English: When using Pemetrexed Fresenius Kabi in combination with cisplatin:
Slovenian: Kadar uporabljamo zdravilo Pemetreksed Fresenius Kabi v kombinaciji s cisplatinom:
English: If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with Pemetrexed Fresenius Kabi.
Slovenian: Če ste bili nedavno cepljeni, prosimo, povejte to zdravniku, saj lahko to ob jemanju zdravila Pemetreksed Fresenius Kabi povzroči škodljive učinke.
English: Contraceptive measures or abstinence are recommended.
Slovenian: Priporočajo se ukrepi proti zanositvi ali vzdržnost.
English: A phase 2 study of pemetrexed in 31 solid tumour patients with stable third space fluid demonstrated no difference in pemetrexed dose normalized plasma concentrations or clearance compared to patients without third space fluid collections.
Slovenian: V študiji s pemetreksedom so v fazi 2 pri 31 bolnikih s solidnim tumorjem in stabilno tekočino tretjega prostora pokazali, da ni razlike med normalno koncentracijo v plazmi ali očistkom, doseženo glede na odmerek pemetrekseda, v primerjavi z bolniki brez zaloge tekočine tretjega prostora.
English: Corticosteriods: your doctor will prescribe you steroid tablets (equivalent to 4 milligram of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after Pemetrexed Fresenius Kabi treatment.
Slovenian: Kortikosteroidi: zdravnik vam bo predpisal tablete steroidov (ustrezno 4 miligramom deksametazona dvakrat dnevno), ki jih boste morali jemati dan pred zdravljenjem z zdravilom Pemetreksed Fresenius Kabi, na dan zdravljenja in na dan po zdravljenju z zdravilom Pemetreksed Fresenius Kabi.
English: Children and adolescents There is no relevant use of Pemetrexed Fresenius Kabi in the paediatric population
Slovenian: Otroci in mladostniki Zdravilo Pemetreksed Fresenius Kabi ni primerno za uporabo pri pediatrični populaciji.
English: Alkaline phosphatase (AP), aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT) should be ≤ 3 times upper limit of normal.
Slovenian: Alkalna fosfataza (AFalkaline phosphatase), aspartatna aminotransferaza (AST - aspartate aminotransferase ali SGOTserum glutamic oxaloacetic transaminase) in alaninska aminotransferaza (ALT - alanine aminotransferase ali SGPT - serum glutamic pyruvic transaminase) morajo biti ≤ 3-kratnik zgornje meje normalnih vrednosti.
English: Treatment with Pemetrexed Fresenius Kabi should be discontinued if a patient experiences any haematologic or non-haematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed.
Slovenian: Zdravljenje z zdravilom Pemetreksed Fresenius Kabi se prekine, če bolnik izkusi kakršno koli hematološko ali nehematološko toksičnost stopnje 3 ali 4 po 2 znižanjih odmerka ali nemudoma, če se opazi nevrološko toksičnost stopnje 3 ali 4.
English: Concomitant use contraindicated Yellow fever vaccine: risk of fatal generalised vaccinale disease (see section 4.3).
Slovenian: Kontraindicirana sočasna uporaba Cepivo proti rumeni mrzlici: tveganje za smrtno generalizirano bolezen po cepljenju (glejte poglavje
English: Clinically relevant Grade 3 and Grade 4 laboratory toxicities were similar between integrated Phase 2 results from three single agent pemetrexed studies (n = 164) and the Phase 3 single agent pemetrexed study described above, with the exception of neutropenia (12.8 % versus 5.3 %, respectively) and alanine aminotransferase elevation (15.2 % versus 1.9 %, respectively).
Slovenian: Klinično pomembne laboratorijske toksičnosti stopenj 3 in 4 so bile podobne pri integriranih rezultatih faze 2 treh študij pemetrekseda kot edine učinkovine (n = 164) in faze 3 študije pemetrekseda kot edine učinkovine, opisane zgoraj, z izjemo nevtropenije (12,8 % oziroma 5,3 %) in povišane vrednosti alaninske aminotransferaze (15,2 % oziroma 1,9 %).
English: Kaplan Meier plots of overall survival by histology
Slovenian: Kaplan Meier-jeva grafa skupnega preživetja glede na histologijo Adenokarcinom
English: 50 % of previous dose (both pemetrexed and cisplatin)
Slovenian: 50 % predhodnega odmerka (obeh pemetrekseda in cisplatina)
English: Pemetrexed Fresenius Kabi in combination with cisplatin The recommended dose of Pemetrexed Fresenius Kabi is 500 mg/m of body surface area (BSA) administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Slovenian: Zdravilo Pemetreksed Fresenius Kabi v kombinaciji s cisplatinom Priporočeni odmerek zdravila Pemetreksed Fresenius Kabi je 500 mg/m telesne površine (BSA - body surface area), dan kot intravenska infuzija v 10 minutah prvi dan vsakega 21-dnevnega cikla.
English: Pemetrexed solutions are for single use only.
Slovenian: Raztopine pemetrekseda so namenjene samo za enkratno uporabo.
English: 75 % of previous dose (both pemetrexed and cisplatin)
Slovenian: 75 % predhodnega odmerka (obeh pemetrekseda in cisplatina)
English: Rare cases of bullous conditions have been reported including Stevens-Johnson syndrome and Toxic epidermal necrolysis which in some cases were fatal.
Slovenian: Poročali so o redkih primerih buloznih stanj, kot sta Stevens-Johnsonov sindrom in toksična epidermalna nekroliza, ki sta bila v nekaterih primerih usodna.
English: ▪ If you experience bleeding from the gums, nose or mouth or any bleeding that would not stop, reddish or pinkish urine, unexpected bruising (since you might have less platelets than normal which is very common).
Slovenian: • Če vam krvavijo dlesni, krvavite iz nosu ali ustne votline, ali se pojavi kakršna koli krvavitev, ki se noče ustaviti, rdečkasto ali rožnato obarvan urin, nepričakovane podplutbe (ker imate lahko manj trombocitov, kot je normalno, kar je zelo pogosto).
English: National Cancer Institute Common Toxicity Criteria (CTC v2.0; NCI 1998)
Slovenian: Merila pogostih toksičnosti Nacionalnega inštituta za rakava obolenja (CTC v2.0; NCI 1998).
English: What Pemetrexed Fresenius Kabi is and what it is used for
Slovenian: Kaj je zdravilo Pemetreksed Fresenius Kabi in za kaj ga uporabljamo
English: How to store Pemetrexed Fresenius Kabi Contents of the pack and other information
Slovenian: Shranjevanje zdravila Pemetreksed Fresenius Kabi Vsebina pakiranja in dodatne informacije
English: Concomitant administration of nephrotoxic medicinal product (e.g. aminoglycoside, loop diuretics, platinum compounds, cyclosporin) could potentially result in delayed clearance of pemetrexed.
Slovenian: Sočasno dajanje nefrotoksičnih zdravil (npr. aminoglikozidov, diuretikov zanke, spojin platine, ciklosporina) lahko potencialno povzroči zakasnjeni očistek pemetrekseda.
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1000 micrograms) that you must take once a day while you are taking Pemetrexed Fresenius Kabi.
Slovenian: Dopolnjevanje vitaminov: zdravnik vam bo predpisal peroralno folno kislino (vitamin) ali multivitaminski pripravek, ki jo vsebuje (350 do 1000 mikrogramov), ki ga boste morali med prejemanjem zdravila Pemetreksed Fresenius Kabi jemati enkrat dnevno.
English: Limited clinical data from a separate randomized, Phase 3, controlled trial, suggest that efficacy data (overall survival, progression free survival) for pemetrexed are similar between patients previously pre treated with docetaxel (n = 41) and patients who did not receive previous docetaxel treatment (n = 540).
Slovenian: Omejeni klinični podatki iz ločeno randomiziranih, kontroliranih preskušanj faze 3, nakazujejo, da so podatki o učinkovitosti (skupno preživetje, preživetje brez napredovanja) za pemetreksed podobni med bolniki, ki so bili predhodno zdravljeni z docetakselom (n = 41) in bolniki, ki niso prejeli predhodnega zdravljenja z docetakselom (n = 540).
English: Germany
Slovenian: Nemčija ali
English: Prior to each chemotherapy administration blood chemistry tests should be collected to evaluate renal and hepatic function.
Slovenian: Pred vsakim dajanjem kemoterapije se opravi tudi teste biokemije seruma za vrednotenje ledvičnega in jetrnega delovanja.
English: Men are advised not to father a child during and up to 6 months following treatment with Pemetrexed Fresenius Kabi and should therefore use effective contraception during treatment with Pemetrexed Fresenius Kabi and for up to 6 months afterwards.
Slovenian: Moškim odsvetujemo, da bi v času zdravljenja z zdravilom Pemetreksed Fresenius Kabi ter do 6 mesecev po zdravljenju s tem zdravilom spočeli otroka, zato naj v času zdravljenja z zdravilom Pemetreksed Fresenius Kabi ter do 6 mesecev po zdravljenju s tem zdravilom uporabljajo učinkovito kontracepcijo.
English: Serious renal events, including acute renal failure, have been reported with pemetrexed alone or in association with other chemotherapeutic agents.
Slovenian: Poročali so o resnih ledvičnih dogodkih, vključno z akutno ledvično odpovedjo, s pemetreksedom samim ali v povezavi z drugimi kemoterapevtiki.
English: Before the start of any cycle of chemotherapy, patients are required to have the following: absolute neutrophil count (ANC) should be ≥ 1500 cells/mm and platelets should be
Slovenian: Pred začetkom katerega koli cikla kemoterapije morajo bolniki izpolnjevati naslednja merila: absolutno število nevtrofilcev (ANC - absolute neutrophil count) mora biti ≥ 1500 celic/mm ter število trombocitov ≥ 100.000 celic/mm
English: This medicine should not been used if there are any signs of particles.
Slovenian: Ne uporabljajte tega zdravila, če opazite trdne delce.
English: ** Refer to NCI CTCAE Criteria (Version 3.0; NCI 2003) for each grade of toxicity.
Slovenian: **Glejte CTC Nacionalnega inštituta za rakava obolenja (verzija 3.0; NCI 2003), za vsako stopnjo toksičnosti.
English: Any Grade 3 or 4 toxicities except mucositis
Slovenian: Katere koli toksičnosti stopnje 3 ali 4, razen vnetja sluznice
English: Pemetrexed Fresenius Kabi can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Slovenian: Zdravnik vam lahko predpiše zdravilo Pemetreksed Fresenius Kabi, če imate pljučni rak v napredovalem stadiju in če se vaša bolezen odziva na zdravljenje oz. če po začetni kemoterapiji ostaja večinoma nespremenjena.
English: Radiation pneumonitis (scarring of the air sacs of the lung associated with radiation therapy) may occur in patients who are also treated with radiation either before, during or after their Pemetrexed Fresenius Kabi therapy.
Slovenian: Radiacijska pljučnica (brazgotinjenje pljučnih mešičkov, povezano z obsevanjem) se lahko pojavi pri bolnikih, ki so zdravljeni tudi z obsevanjem pred, med ali po zdravljenju z zdravilom Pemetreksed Fresenius Kabi.
English: Efficacy of pemetrexed vs docetaxel in NSCLC - ITT population Pemetrexed
Slovenian: Učinkovitost pemetrekseda v primerjavi z docetakselom pri NSCLC - populacija NZ
English: For precautions to be taken before handling or administering Pemetrexed Fresenius Kabi, see section 6.6.
Slovenian: Za previdnostne ukrepe potrebne pred ravnanjem z zdravilom ali dajanjem zdravila Pemetreksed Fresenius Kabi glejte poglavje 6.6.
English: If you are concerned about any side effects, talk to your doctor.
Slovenian: Če ste zaradi katerega koli neželenega učinka (neželenih učinkov) zaskrbljeni, se pogovorite z zdravnikom.
English: The use of Pemetrexed Fresenius Kabi should be avoided during pregnancy.
Slovenian: Uporabi zdravila Pemetreksed Fresenius Kabi med nosečnostjo se izogibamo.
English: Docetaxel N = 276
Slovenian: docetaksel N = 276
English: Further dilution by a healthcare provider is required prior to administration.
Slovenian: Pred dajanjem mora zdravstveni delavec raztopino še nadalje redčiti.
English: ▪ If you experience tiredness, feeling faint, becoming easily breathless or if you look pale (since you might have less haemoglobin than normal which is very common).
Slovenian: • Če ste utrujeni, omotični, se hitro zadihate, ste bledi (ker imate morda manj hemoglobina, kot je normalno, kar je zelo pogosto).
English: You will also receive an injection of vitamin B12 (1000 micrograms) in the week before administration of Pemetrexed Fresenius Kabi and then approximately every 9 weeks (corresponding to 3 courses of Pemetrexed Fresenius Kabi treatment).
Slovenian: V tednu pred dajanjem zdravila Pemetreksed Fresenius Kabi boste prejeli tudi injekcijo vitamina B12 (1000 mikrogramov), nato pa še približno na vsakih 9 tednov (ustrezno 3 ciklom zdravljenja z zdravilom Pemetreksed Fresenius Kabi).
English: All patients were diagnosed with locally advanced or metastatic non-small cell lung cancer and received prior chemotherapy.
Slovenian: Vsi bolniki so imeli postavljeno diagnozo lokalno napredovalega ali metastatskega nedrobnoceličnega pljučnega raka ter so v preteklosti prejemali kemoterapijo.
English: Infectious and non-infectious disorders of the dermis, the hypodermis and/or the subcutaneous tissue have been reported with an unknown frequency (e.g. acute bacterial dermo-hypodermitis,
Slovenian: Poročali so o infektivnih in neinfektivnih boleznih dermisa, hipodermisa in/ali podkožja z neznano pogostnostjo (npr. akutni bakterijski dermohipodermitis, psevdocelulitis, dermatitis).
English: Dose reductions for subsequent cycles are based on nadir ANC, platelet count and maximum non-haematologic toxicity seen from the previous cycle (see section 4.2).
Slovenian: Odmerki se v naslednjih ciklih nižajo na podlagi najnižjega ANC, števila trombocitov ter največje nehematološke toksičnosti iz prejšnjega cikla (glejte poglavje 4.2).
English: During post marketing surveillance, the following adverse reactions have been reported in patients treated with pemetrexed:
Slovenian: V nadzoru po prihodu zdravila na trg so pri bolnikih, ki so jih zdravili s pemetreksedom, poročali o naslednjih neželenih učinkih:
English: Hydrochloric acid concentrated (E507) (pH adjustment) Trometamol (pH adjustment)
Slovenian: 6.1 Seznam pomožnih snovi manitol (E421) koncentrirana klorovodikova kislina (E507) (za uravnavanje pH) trometamol (za uravnavanje pH)
English: Nadir platelets < 50,000 /mm regardless of nadir ANC
Slovenian: Najnižje število trombocitov < 50.000 /mm ne glede na najnižji ANC
English: Dose of pemetrexed (mg/m
Slovenian: Odmerek pemetrekseda (mg/m
English: Pemetrexed Fresenius Kabi must only be administered under the supervision of a physician qualified in the use of anti-cancer chemotherapy.
Slovenian: Zdravilo Pemetreksed Fresenius Kabi se sme dajati le pod nadzorom zdravnika, usposobljenega za uporabo kemoterapije za zdravljenje raka.
English: Patients should be monitored for myelosuppression during therapy and pemetrexed should not be given to patients until absolute neutrophil count (ANC) returns to ≥ 1500 cells/mm and platelet count returns to ≥ 100,000 cells/mm
Slovenian: Pri bolnikih moramo biti med zdravljenjem pozorni na morebiten pojav mielosupresije, pemetrekseda pa bolnikom ne smemo dajati, dokler se absolutno število nevtrofilcev (ANC) ne povrne na ≥ 1500 celic/mm ter število trombocitov na ≥ 100.000 celic/mm
English: ▪ Allergic reaction: if you develop skin rash (very common) / burning or prickling sensation (common), or fever (common).
Slovenian: • Alergijska reakcija: če se pojavi izpuščaj (zelo pogosto)/pekoč ali zbadajoč občutek (pogosto),
English: Rarely seen events include Stevens-Johnson syndrome and Toxic epidermal necrolysis.
Slovenian: Redkeje opažena dogodka sta Stevens-Johnsonov sindrom in toksična epidermalna nekroliza.
English: What you need to know before you use Pemetrexed Fresenius Kabi
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Pemetreksed Fresenius Kabi
English: SGOT (AST) elevation
Slovenian: Povišanje SGOT (AST)
English: Pemetrexed is a multi-targeted anti-cancer antifolate agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication.
Slovenian: Pemetreksed je večtarčna protirakava antifolatna učinkovina, ki deluje s porušenjem ključnih presnovnih procesov, odvisnih od folata, ki so nujni za podvajanje celic.
English: In patients with normal renal function (creatinine clearance > 80 ml/min), high doses of non-steroidal anti-inflammatory medicinal product (NSAIDs, such as ibuprofen > 1600 mg/day) and acetylsalicylic acid at higher dose (> 1.3 g daily) may decrease pemetrexed elimination and, consequently, increase the occurrence of pemetrexed adverse events.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic (očistek kreatinina ≥ 80 ml/min) lahko visoki odmerki nesteroidnih protivnetnih zdravil (NSAIDs, kot je ibuprofen > 1600 mg/dan) in acetilsalicilna kislina v visokih odmerkih (≥ 1,3 g dnevno) zmanjšajo eliminacijo pemetrekseda in tako lahko povečajo pojavnost neželenih učinkov pemetrekseda.
English: CTC
Slovenian: Stopnja CTC
English: Pemetrexed Fresenius Kabi 100 mg:
Slovenian: Pemetreksed Fresenius Kabi 100 mg:
English: You will always receive Pemetrexed Fresenius Kabi by infusion into one of your veins.
Slovenian: Zdravilo Pemetreksed Fresenius Kabi boste vedno prejeli v obliki infuzije v veno.
English: All patients were diagnosed with Stage IIIB or IV NSCLC and had received prior platinum-based chemotherapy.
Slovenian: Vsi bolniki so imeli diagnozo nedrobnoceličnega pljučnega raka IIIB ali IV stopnje in so predhodno prejemali kemoterapijo na osnovi platine.
English: There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore the use of pemetrexed is not recommended (see section 4.4).
Slovenian: O uporabi pemetrekseda pri bolnikih z očistkom kreatinina, nižjim od 45 ml/min, ni zadostnih podatkov; zato se uporabe pemetrekseda pri teh bolnikih ne priporoča (glejte poglavje 4.4).
English: Excipients: Mannitol, hydrochloric acid concentrated, trometamol
Slovenian: Pomožne snovi: manitol, koncentrirana klorovodikova kislina, trometamol.