FrancophonIA/ELRC3.0 huggingface dataset:
English: Cayston was compared with placebo (a dummy treatment) in two main studies involving a total of 375 patients with cystic fibrosis who had long-term lung infection due to P.aeruginosa, most of whom were adults.
Danish: Cayston blev sammenlignet med placebo (en virkningsløs behandling) i to hovedundersøgelser af i alt 375 patienter med cystisk fibrose, som havde langvarig lungebetændelse forårsaget af P.aeruginosa, og hvoraf de fleste var voksne.
English: What is Cayston?
Danish: Hvad er Cayston?
English: Cayston is used to suppress long-term lung infection caused by P. aeruginosa bacteria in adults and children aged six years or older with cystic fibrosis.
Danish: Cayston anvendes til supprimering af langvarig lungeinfektion forårsaget af P. aeruginosa-bakterier hos voksne og børn over seks år med cystisk fibrose.
English: In cystic fibrosis these secretions become thick, blocking the airways and the flow of digestive juices.
Danish: Ved cystisk fibrose bliver disse væsker seje, så de blokerer for luftvejene og passagen af fordøjelsesvæsker.
English: Cayston was more effective than placebo at suppressing lung infection caused by P. aeruginosa bacteria in patients with cystic fibrosis.
Danish: Cayston var mere effektivt end placebo til supprimering af lungeinfektion forårsaget af P. aeruginosabakterier hos patienter med cystisk fibrose.
English: Cystic fibrosis is an inherited disease that affects the cells that secret mucus in the lungs and the cells that secret digestive juices from the glands in the gut and pancreas.
Danish: Cystisk fibrose er en arvelig sygdom, der angriber lungernes slimproducerende celler og de kirtelceller i tarmen og bugspytkirtlen, der udskiller fordøjelsesvæsker.
English: How has Cayston been studied?
Danish: Hvordan blev Cayston undersøgt?
English: What is Cayston used for?
Danish: Hvad anvendes Cayston til?
English: What benefit has Cayston shown during the studies?
Danish: Hvilken fordel viser undersøgelserne, at der er ved Cayston?
English: How is Cayston used?
Danish: Hvordan anvendes Cayston?
English: A bronchodilator (a medicine that widens the airways in the lungs) should be used before each dose of Cayston.
Danish: Før hver dosis af Cayston bør der gives en bronkodilator (medicin, der udvider luftvejene i lungerne).
English: How does Cayston work?
Danish: Hvordan virker Cayston?
English: The main measure of effectiveness was based on improvements in patients' forced expiratory volumes (FEV1, the maximum volume of air a person can breathe out in one second).
Danish: Virkningen blev hovedsagelig bedømt på bedringen i patienternes forcerede ekspirationsvolumen (FEV1, dvs. den maksimale luftmængde, som en person kan udånde på et sekund) I en yderligere undersøgelse sammenlignedes fire ugers behandling med henholdsvis Cayston og placebo hos patienter med mild lungesygdom forårsaget af cystisk fibrose.
English: Date of first authorisation: 4 January 2007 Date of latest renewal: 21 November 2011
Danish: Dato for første tilladelse: 4. januar 2007 Dato for seneste fornyelse: 21. november 2011
English: As well as your treatment with ADROVANCE, your doctor may suggest you make changes to your lifestyle to help your condition, such as:
Danish: Såvel som behandling med ADROVANCE kan din læge foreslå, at du foretager nogle ændringer i din livsstil, som kan hjælpe dig i din tilstand, for eksempel:
English: Frequencies are defined as: very common (≥1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000)
Danish: Frekvenserne er defineret således: Meget almindelig (≥ 1/10), almindelig ( 1/100 til < 1/10), ikke almindelig ( 1/1.000 til < 1/100), sjælden ( 1/10.000 til < 1/1.000), meget sjælden (< 1/10.000).
English: Therefore, caution should be used when these medicines are taken at the same time as ADROVANCE.
Danish: Derfor skal der udvises forsigtighed, når disse lægemidler tages samtidigt med ADROVANCE.
English: Supplemental vitamin D reduces these risks and their consequences.
Danish: Dvitamintilskud reducerer disse risici og deres konsekvenser.
English: Pharmacotherapeutic group: Drugs for treatment of bone diseases, Bisphosphonates, combinations, ATC code: M05BB03
Danish: Farmakoterapeutisk klassifikation: Lægemidler til behandling af knoglesygdomme, bisphosphonater, kombinationer, ATC-kode: M05BB03
English: Since it is not known how long you should take ADROVANCE, you should discuss the need to stay on this medicine with your doctor periodically to determine if ADROVANCE is still right for you.
Danish: Da det er ukendt, hvor lang tid du skal tage ADROVANCE, skal du med jævne mellemrum diskutere behovet for at fortsætte med dette lægemiddel med din læge for at afgøre, om ADROVANCE stadig er rigtigt for dig.
English: Talk to your doctor or pharmacist before taking ADROVANCE if:
Danish: Kontakt lægen eller apotekspersonalet, før du tager ADROVANCE, hvis:
English: ADROVANCE is effective only if taken when your stomach is empty.
Danish: ADROVANCE er kun effektivt, hvis det tages på tom mave.
English: It is important that you take ADROVANCE for as long as your doctor prescribes the medicine.
Danish: Det er vigtigt, at du tager ADROVANCE, så længe din læge foreskriver medicinen.
English: - Inability to stand or sit upright for at least 30 minutes.
Danish: Manglende evne til at stå eller sidde oprejst i mindst 30 minutter.
English: It contains important information reminding you how to take ADROVANCE properly.
Danish: Det indeholder vigtig information, som vil minde dig om, hvordan du tager ADROVANCE korrekt.
English: Children and adolescents ADROVANCE should not be given to children and adolescents less than 18 years of age.
Danish: Børn og unge ADROVANCE bør ikke gives til børn og unge under 18 år.
English: In case of overdose with ADROVANCE, milk or antacids should be given to bind alendronate.
Danish: I tilfælde af overdosering med ADROVANCE bør der indtages mælk eller antacida for at binde alendronat.
English: Remember, take ADROVANCE once each week on that same day for as long as your doctor prescribes it.
Danish: Husk at tage ADROVANCE én gang om ugen på den samme ugedag, så længe din læge foreskriver det.
English: The need for continued treatment should be re-evaluated periodically based on the benefits and potential risks of ADROVANCE on an individual patient basis, particularly after 5 or more years of use.
Danish: Behovet for fortsat behandling skal revurderes regelmæssigt, baseret på fordele og mulige risici af ADROVANCE for den enkelte patient, især efter anvendelse i 5 år eller mere.
English: If you take more ADROVANCE than you should If you take too many tablets by mistake, drink a full glass of milk and contact your doctor immediately.
Danish: Hvis du ved en fejltagelse kommer til at tage for mange tabletter, skal du drikke et helt glas mælk og straks kontakte din læge.
English: ADROVANCE is only intended for use in postmenopausal women and therefore it should not be used during pregnancy or in breast-feeding women.
Danish: ADROVANCE er kun beregnet til anvendelse hos postmenopausale kvinder, og bør derfor ikke anvendes under graviditet eller af ammende kvinder.
English: • you have, or have recently had, any swallowing or digestive problems,
Danish: • Du har eller for nyligt har haft synkebesvær eller har fordøjelsesproblemer,
English: It is important to maintain good oral hygiene when being treated with ADROVANCE.
Danish: Det er vigtigt at opretholde en god mundhygiejne, når du er i behandling med ADROVANCE.
English: What is ADROVANCE used for?
Danish: Hvad anvendes ADROVANCE til?
English: These side effects may worsen if patients continue to take ADROVANCE after developing these symptoms.
Danish: Disse bivirkninger kan forværres, hvis patienten fortsætter med at tage ADROVANCE efter at have udviklet sådanne symptomer.
English: ADROVANCE should not be used during pregnancy.
Danish: ADROVANCE må ikke anvendes under graviditet.
English: ADROVANCE studies
Danish: ADROVANCE undersøgelser
English: What is ADROVANCE?
Danish: Hvad er ADROVANCE?
English: Contact your doctor if you experience pain, weakness or discomfort in your thigh, hip or groin as this may be an early indication of a possible fracture of the thigh bone,
Danish: Kontakt lægen, hvis du får smerter, svaghed eller ubehag i låret, hoften eller lysken, idet det kan være tidlige tegn på et muligt brud på lårbensknoglen.
English: In patients with these conditions, serum calcium and symptoms of hypocalcaemia should be monitored during therapy with ADROVANCE.
Danish: Hos patienter med disse lidelser bør serumcalcium og symptomer på hypokalcæmi monitoreres under behandling med ADROVANCE.
English: The safety and efficacy of ADROVANCE in children less than 18 years of age have not been established.
Danish: ADROVANCEs sikkerhed og virkning hos børn under 18 år er ikke klarlagt.
English: ADROVANCE has no or negligible direct influence on the ability to drive and use machines.
Danish: ADROVANCE påvirker ikke eller kun i ubetydelig grad evnen til at føre motorkøretøj og betjene maskiner.
English: It is very important to follow instructions 2), 3), 4) and 5) to help the ADROVANCE tablet reach your stomach quickly and help reduce the chance of irritating your gullet (oesophagus - the tube that connects your mouth with your stomach).
Danish: Det er meget vigtigt, at du følger instruktionerne 2-5 for at ADROVANCE-tabletten hurtigt kan komme ned i maven og for at nedsætte risikoen for irritation af spiserøret (øsofagus - det rør der forbinder din mund med maven).
English: Hypocalcaemia must be corrected before initiating therapy with ADROVANCE (see section 4.3).
Danish: Hypokalcæmi skal korrigeres før behandling med ADROVANCE indledes (se pkt.
English: • Patients should not lie down for at least 30 minutes after taking ADROVANCE and until after the first food of the day.
Danish: • Patienten må ikke ligge ned de første 30 minutter efter indtagelse af ADROVANCE og før dagens første måltid er indtaget.
English: When you get out of bed on the day you have chosen, and before taking your first food, drink or other medicines, swallow (do not crush or chew the tablet or allow it to dissolve in your mouth) one ADROVANCE tablet with a full glass of water (not mineral water).
Danish: Når du står op på den valgte ugedag, og før du indtager dagens første måltid, drikkevarer eller anden medicin, skal du sluge én ADROVANCE tablet (du må ikke knuse eller tygge tabletten eller opløse den i munden) med et helt glas postevand (ikke mineralvand).
English: The content of vitamin D in ADROVANCE is not suitable for correction of vitamin D deficiency.
Danish: Indholdet af D-vitamin i ADROVANCE er ikke velegnet til opretning af D-vitaminmangel.
English: Due to the nature of the disease process in osteoporosis, ADROVANCE is intended for long-term use.
Danish: På grund af sygdomsprocessen ved osteoporose er ADROVANCE beregnet til langtidsbehandling.
English: Concentrations of alendronate in plasma following therapeutic oral doses are too low for analytical detection (< 5 ng/ml).
Danish: Koncentrationen af alendronat i plasma efter terapeutiske, orale doser er under analysegrænsen (< 5ng/ml).
English: Irritation, inflammation or ulceration of the gullet (oesophagus - the tube that connects your mouth with your stomach) often with symptoms of chest pain, heartburn, or difficulty or pain upon swallowing may occur, especially if patients do not drink a full glass of water and/or if they lie down less than 30 minutes after taking ADROVANCE.
Danish: Irritation, betændelse eller sårdannelse i spiserøret (øsofagus - det rør der forbinder din mund med maven), ofte med symptomer såsom brystsmerter, halsbrand, synkebesvær eller synkesmerter opstår især, hvis patienten ikke drikker et helt glas vand, og/eller hvis man lægger sig ned inden 30 minutter, efter man har taget ADROVANCE.
English: ADROVANCE is indicated for the treatment of postmenopausal osteoporosis in women at risk of vitamin D insufficiency.
Danish: ADROVANCE er indiceret til behandling af postmenopausal osteoporose hos kvinder med risiko for D-vitaminmangel.
English: Your doctor has prescribed ADROVANCE to treat your osteoporosis and because you are at risk of vitamin D insufficiency.
Danish: Din læge har ordineret ADROVANCE til at behandle din knogleskørhed, og fordi du er i risiko for Dvitaminmangel.
English: • ADROVANCE should only be swallowed after getting up for the day with a full glass of water (not less than 200 ml).
Danish: • ADROVANCE skal tages, efter patienten er stået op, og det skal tages sammen med et helt glas postevand (mindst 200 ml).
English: An Instruction Card is included in the carton for ADROVANCE.
Danish: Der er vedlagt et instruktionskort i ADROVANCE pakningen.
English: - Abnormalities of the oesophagus and other factors which delay oesophageal emptying such as stricture or achalasia.
Danish: Øsofagusabnormaliteter og andre faktorer, som forsinker øsofagustømning, såsom striktur eller akalasi.
English: You may be advised to have a dental check-up before starting treatment with ADROVANCE.
Danish: Du kan blive rådet til et tandlægebesøg, før du begynder behandling med ADROVANCE.
English: 5) If you develop difficulty or pain upon swallowing, chest pain, or new or worsening heartburn, stop taking ADROVANCE and contact your doctor.
Danish: Hvis du udvikler synkebesvær, synkesmerter, brystsmerter eller ny/forværret halsbrand, skal du stoppe med at tage ADROVANCE og kontakte din læge.
English: ADROVANCE must be taken with water only (not mineral water) at least 30 minutes before the first food, beverage, or medicinal product (including antacids, calcium supplements and vitamins) of the day.
Danish: ADROVANCE skal tages sammen med almindeligt postevand (ikke mineralvand) mindst 30 minutter før indtagelse af dagens første måltid, drikkevarer eller lægemidler (inklusive antacida, calciumtilskud og vitaminer).
English: The mean half-life of vitamin D3 in the serum following an oral dose of ADROVANCE (70 mg/2,800 IU) is approximately 24 hours.
Danish: Gennemsnitlig halveringstid for D3-vitamin i serum efter oral dosis ADROVANCE (70 mg/2.800 IE) er ca. 24 timer.
English: Physicians should therefore be alert to any signs or symptoms signalling a possible oesophageal reaction and patients should be instructed to discontinue alendronate and seek medical attention if they develop symptoms of oesophageal irritation such as dysphagia, pain on swallowing or retrosternal pain or new or worsening heartburn (see section 4.8).
Danish: Lægen skal derfor være opmærksom på alle tegn og symptomer, der kan indikere mulige øsofageale reaktioner, og patienterne skal instrueres om at seponere behandlingen med alendronat og søge læge, hvis de udvikler symptomer på øsofageal irritation, såsom dysfagi, synkesmerter, retrosternale smerter eller ny/forværret halsbrand (se pkt.
English: Take one ADROVANCE tablet once a week.
Danish: Tag én ADROVANCE tablet én gang ugentligt.
English: Because there is a potential for worsening of the underlying disease, caution should be used when alendronate is given to patients with active upper gastrointestinal problems, such as dysphagia, oesophageal disease, gastritis, duodenitis, ulcers, or with a recent history (within the previous year) of major gastrointestinal disease such as peptic ulcer, or active gastrointestinal bleeding, or surgery of the upper gastrointestinal tract other than pyloroplasty (see section 4.3).
Danish: På grund af risiko for forværring af den tilgrundliggende sygdom, skal der udvises forsigtighed, når alendronat gives til patienter med aktive, øvre gastrointestinale problemer, såsom dysfagi, øsofagussygdom, gastritis, duodenitis, ulcera eller alvorlig gastrointestinal sygdom, såsom peptisk ulcus (inden for det seneste år), aktiv gastrointestinal blødning, eller til patienter, der har fået foretaget kirurgiske indgreb i øvre gastrointestinalkanal ud over pyloroplastik (se pkt.
English: Do not take ADROVANCE
Danish: Tag ikke ADROVANCE
English: ADROVANCE is a tablet containing the two active substances, alendronic acid (commonly called alendronate) and colecalciferol known as vitamin D3.
Danish: ADROVANCE er en tablet, der indeholder to aktive stoffer, alendronsyre (kaldes normalt alendronat) og cholecalciferol, kendt som D3-vitamin.
English: Olestra, mineral oils, orlistat, and bile acid sequestrants (e.g. cholestyramine, colestipol) may impair the absorption of vitamin D.
Danish: Olestra, mineralske olier, orlistat og galdesyremidler (colestyramin, colestipol) kan svække optagelsen af D-vitamin.
English: ADROVANCE contains lactose and sucrose.
Danish: ADROVANCE indeholder lactose og saccharose.
English: Every week, take one ADROVANCE tablet on your chosen day.
Danish: Tag én ADROVANCE tablet hver uge på den valgte ugedag.
English: How to take ADROVANCE tablets
Danish: Sådan skal du tage ADROVANCE tabletterne
English: 4) Do not take ADROVANCE at bedtime or before getting up for the day.
Danish: Tag ikke ADROVANCE ved sengetid, eller før du står op.
English: Patients should be instructed that if they miss a dose of ADROVANCE they should take one tablet on the morning after they remember.
Danish: Patienterne bør informeres om, at hvis de glemmer at tage en ADROVANCE tablet, skal de tage den morgenen efter, de er kommet i tanke herom.
English: 6) After swallowing your ADROVANCE tablet, wait at least 30 minutes before taking your first food, drink, or other medicine of the day, including antacids, calcium supplements and vitamins.
Danish: Når du har slugt ADROVANCE tabletten, skal du vente mindst 30 minutter, før du indtager dagens første måltid, drikke eller anden medicin, også syreneutraliserende midler, kalktilskud og vitaminer.
English: Always take ADROVANCE exactly as your doctor or pharmacist has told you.
Danish: Tag altid ADROVANCE nøjagtigt efter lægens eller apotekspersonalets anvisning.
English: If you stop taking ADROVANCE
Danish: Hvis du holder op med at tage ADROVANCE
English: If you miss a dose, take only one ADROVANCE tablet on the morning after you remember.
Danish: Hvis du glemmer en tablet, skal du blot tage en ADROVANCE tablet om morgenen efter, du er kommet i tanke om det.
English: Common alopecia
Danish: Alopeci
English: There have been side effects (for example blurred vision, dizziness and severe bone, muscle or joint pain) reported with ADROVANCE that may affect your ability to drive or operate machinery (see section 4).
Danish: Der er set bivirkninger med ADROVANCE (f.eks. sløret syn, svimmelhed og alvorlige knogle-, muskel- eller ledsmerter), som kan påvirke evnen til at køre bil eller betjene maskiner (se punkt 4).
English: If you forget to take ADROVANCE
Danish: Hvis du har glemt at tage ADROVANCE
English: What you need to know before you take ADROVANCE
Danish: Det skal du vide, før du begynder at tage ADROVANCE
English: The bioavailability of the 5,600 IU vitamin D3 in ADROVANCE is similar to 5,600 IU vitamin D3 administered alone.
Danish: Biotilgængeligheden for 5.600 IE D3-vitamin i ADROVANCE er lig med 5.600 IE D3-vitamin, administreret alene.
English: It is likely that calcium supplements, antacids, and some oral medicines will interfere with the absorption of ADROVANCE if taken at the same time.
Danish: Det er sandsynligt, at kalktilskud, syreneutraliserende midler og nogle andre former for medicin, der tages gennem munden, vil påvirke kroppens optagelse af ADROVANCE, hvis det tages samtidigt.
English: Patients received the lower strength (70 mg/2,800 IU) of ADROVANCE (n=350) or FOSAMAX (alendronate) 70 mg (n=332) once a week; additional vitamin D supplements were prohibited.
Danish: Patienterne fik den lavere styrke (70 mg/2.800 IE) af ADROVANCE (n=350) eller FOSAMAX (alendronat) 70 mg (n=332) en gang ugentligt; yderligere D-vitamin tilskud var ikke tilladt.
English: What ADROVANCE contains
Danish: ADROVANCE indeholder:
English: • Patients should only swallow ADROVANCE whole.
Danish: • Patienten skal sluge ADROVANCE tabletten hel.
English: - Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Danish: Overfølsomhed over for de aktive stoffer eller over for et eller flere af hjælpestofferne anført i pkt.
English: It is likely that food and beverages (including mineral water) will make ADROVANCE less effective if taken at the same time.
Danish: Brug af ADROVANCE sammen med mad og drikke Det er sandsynligt, at mad og drikke (også mineralvand) vil nedsætte virkningen af ADROVANCE, hvis det indtages på samme tid.
English: The bioavailability of the 2,800 IU vitamin D3 in ADROVANCE is similar to 2,800 IU vitamin D3 administered alone.
Danish: Biotilgængeligheden for 2.800 IE D3-vitamin i ADROVANCE er lig med 2.800 IE D3-vitamin, administreret alene.
English: No dose adjustment is necessary for patients with a creatinine clearance greater than 35 ml/min.
Danish: Dosisjustering er ikke nødvendig hos patienter med kreatinin-clearance > 35 ml/min.
English: A. MANUACTURER(S) RESPONSIBLE FOR BATCH RELEASE
Danish: A. FREMSTLLER(E) ANSVARLIG(E) FOR BATCHFRIGIVELSE
English: - Hypocalcaemia.
Danish: Hypokalcæmi.
English: Patients in the Vitamin D3 2,800 group received ADROVANCE (70 mg/2,800 IU) (n=299) and patients in the Vitamin D3 5,600 group received ADROVANCE (70 mg/2,800 IU) plus an additional 2,800 IU vitamin D3 (n=309) once a week; additional vitamin D supplements were allowed.
Danish: Patienter i D3-vitamin 2.800 gruppen fik ADROVANCE (70 mg/2.800 IE) (n=299), og patienter i D3-vitamin 5.600 gruppen fik ADROVANCE (70 mg/2.800 IE) plus yderligere 2.800 IE D3-vitamin (n=309) en gang ugentligt; yderligere Dvitamintilskud var tilladt.
English: The effect of the lower dose of ADROVANCE (alendronate 70 mg/vitamin D3 2,800 IU) on vitamin D status was demonstrated in a 15-week, multinational study that enrolled 682 osteoporotic postmenopausal women (serum 25-hydroxyvitamin D at baseline: mean, 56 nmol/l [22.3 ng/ml]; range, 22.5-225 nmol/l [9-90 ng/ml]).
Danish: Effekten af den lave dosis af ADROVANCE (alendronat 70 mg/D3-vitamin 2.800 IE) på D-vitamin status blev påvist i en 15 ugers multinational undersøgelse, der inkluderede 682 postmenopausale kvinder med osteoporose (serum 25-hydroxyvitamin D ved baseline: Gennemsnit, 56 nmol/l [22,3 ng/ml]; variationsbredde, 22,5-225 nmol/l [9-90 ng/ml]).
English: The alendronate component in the ADROVANCE (70 mg/2,800 IU) combination tablet and the ADROVANCE (70 mg/5,600 IU) combination tablet is bioequivalent to the alendronate 70 mg tablet.
Danish: Alendronatkomponenten i ADROVANCE (70 mg/2.800 IE) kombinationstabletten og ADROVANCE (70 mg/5.600 IE) kombinationstabletten er bioækvivalent med alendronat i 70 mg tabletten.
English: The effect of the lower dose of ADROVANCE (alendronate 70 mg/vitamin D3 2,800 IU) plus an additional 2,800 IU Vitamin D3 for a total of 5,600 IU (the amount of vitamin D3 in the higher dose of ADROVANCE) once weekly was demonstrated in a 24-week, extension study that enrolled 619 osteoporotic post-menopausal women.
Danish: Effekten af den lave dosis af ADROVANCE (alendronat 70 mg/D3-vitamin 2.800 IE) plus yderligere 2.800 IE D3-vitamin til i alt 5.600 IE (mængden af D3-vitamin i den høje dosis af ADROVANCE) en gang ugentligt blev påvist i en 24 ugers ekstensionsundersøgelse, der inkluderede 619 postmenopausale kvinder med osteoporose.
English: ADROVANCE 70 mg/2,800 IU tablets EU/1/06/364/001 - 2 tablets
Danish: ADROVANCE 70 mg/2.800 IE tabletter EU/1/06/364/001 - 2 tabletter
English: In this study, mean 25-hydroxyvitamin D levels in patients with vitamin D insufficiency at baseline (25-hydroxyvitamin D, 22.5 to 37.5 nmol/l [9 to < 15 ng/ml]) increased from 30 nmol/l (12.1 ng/ml) to 40 nmol/l (15.9 ng/ml) at week 15 in the ADROVANCE (70 mg/2,800 IU) group (n=75) and decreased from 30 nmol/l (12.0 ng/ml) at baseline to 26 nmol/l (10.4 ng/ml) at week 15 in the alendronate-only group (n=70).
Danish: I denne undersøgelse øgedes de gennemsnitlige 25-hydroxyvitamin D niveauer hos patienter med D-vitaminmangel ved baseline (25-hydroxyvitamin D, 22,5 til 37,5 nmol/l [9 til < 15 ng/ml]) fra 30 nmol/l (12,1 ng/ml) til 40 nmol/l (15,9 ng/ml) ved uge 15 i ADROVANCE (70 mg/2.800 IE)-gruppen (n=75) og faldt fra 30 nmol/l (12,0 ng/ml) ved baseline til 26 nmol/l