FrancophonIA/ELRC3.0 huggingface dataset:
English: Patients treated with lixisenatide should be advised of the potential risk of dehydration in relation to gastrointestinal adverse reactions and take precautions to avoid fluid depletion.
Croatian: Bolesnike liječene liksisenatidom treba upozoriti na potencijalni rizik od dehidracije povezan s gastrointestinalnim nuspojavama te im savjetovati da poduzmu mjere opreza kako bi izbjegli gubitak tekućine.
English: A clinical study was conducted in insulin-naive patients insufficiently controlled on oral antidiabetic agents.
Croatian: Provedeno je kliničko ispitivanje s bolesnicima prethodno neliječenim inzulinom i koji su nedovoljno dobro kontrolirani oralnim antidijabeticima.
English: In patients newly started on insulin, body weight remained almost unchanged in the lixisenatide group while an increase was shown in the placebo group.
Croatian: U bolesnika koji su po prvi puta započeli liječenje inzulinom tjelesna težina ostala je gotovo nepromijenjena u skupini na liksisenatidu, dok je u skupini na placebu primijećeno povećanje.
English: Do not use this Lyxumia pack.
Croatian: Nemojte upotrijebiti to pakiranje lijeka Lyxumia.
English: In case of air bubbles see the “Questions and answers” section.
Croatian: Ako u brizgalici ima mjehurića zraka, pročitajte dio "Pitanja i odgovori".
English: You must dispose of the needle after each use, in an appropriate sharp's container, following local recommendations.
Croatian: Nakon svake uporabe iglu morate odložiti prema lokalnim preporukama u odgovarajući spremnik za oštre predmete.
English: Repeat Section 3 for your daily injections until your pen is empty.
Croatian: Za svakodnevne injekcije ponavljajte korake iz dijela 3 dok ne ispraznite brizgalicu.
English: Patients with type 2 diabetes with basal insulin combined with 1-3 oral anti-diabetic agents were enrolled in an open-label randomised study for insulin intensification.
Croatian: Bolesnici s dijabetesom tipa 2 koji se liječe bazalnim inzulinom u kombinaciji s 1-3 oralna antidijabetika bili su uključeni u otvoreno randomizirano ispitivanje s ciljem intenziviranja inzulinske terapije.
English: This effect on post-prandial glucose was confirmed in a 4-week study versus liraglutide 1.8 mg once a day in combination with metformin.
Croatian: Učinak na glukozu nakon obroka potvrđen je u 4-tjednom ispitivanju u kojem je liksisenatid uspoređivan s liraglutidom u dozi od 1,8 mg jedanput na dan u kombinaciji s metforminom.
English: • Only inject one dose per day.
Croatian: • Injicirajte samo jednu dozu na dan.
English: Evening (N= 255)
Croatian: navečer (N=255)
English: If you miss a dose of Lyxumia, you can inject it in the hour before your next meal.
Croatian: Ako ste propustili dozu lijeka Lyxumia, možete je injicirati unutar sat vremena prije sljedećeg obroka.
English: The AUC and Cmax of the active metabolite (ramiprilat) were not affected.
Croatian: Nije bilo utjecaja na AUC ni Cmax aktivnog metabolita (ramiprilata).
English: No related effect on spermatogenesis was seen in healthy men.
Croatian: U zdravih muškaraca nije primijećen s tim povezan učinak na spermatogenezu.
English: Use of GLP-1 receptor agonists may be associated with gastrointestinal adverse reactions.
Croatian: Primjena agonista receptora GLP-1 može biti povezana s gastrointestinalnim nuspojavama.
English: CV: cardiovascular, MI: myocardial infarction, HF: hospitalization for heart failure, Revasc: coronary revascularization procedure, HR: hazard ratio, CI: confidence interval.
Croatian: KV: kardiovaskularno, IM: infarkt miokarda, HF: hospitalizacija zbog zatajenja srca, Revasc: postupak koronarne revaskularizacije, OH: omjer hazarda, IP: interval pouzdanosti
English: Fertility Animal studies do not indicate direct harmful effects with respect to fertility.
Croatian: Plodnost Istraživanja na životinjama ne upućuju na izravne štetne učinke na plodnost.
English: This helps prevent contamination and potential needle blockage.
Croatian: Time se sprječava kontaminacija i moguće začepljenje igle.
English: At the end of the study, 43.6% (main meal group) and 42.8% (breakfast group) of patients achieved an HbA1c less than 7%.
Croatian: Na kraju ispitivanja, 43,6% (skupina s primjenom uz glavni obrok) i 42,8% (skupina s primjenom uz doručak) bolesnika postiglo je vrijednost HbA1c manju od 7%.
English: Following subcutaneous administration to patients with type 2 diabetes, the rate of lixisenatide absorption is rapid and not influenced by the dose administered.
Croatian: Nakon supkutane primjene bolesnicima sa šećernom bolešću tipa 2 apsorpcija liksisenatida je brza, a na nju ne utječe visina primijenjene doze.
English: Do not use this medicine after the expiry date which is stated on the pen label and on the carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici brizgalice i kutiji iza oznake „EXP“.
English: Frail patients, including patients at risk for malnutrition, patients with recent cardiovascular events and patients with moderate to severe cognitive impairment were excluded.
Croatian: Slabiji bolesnici, uključujući bolesnike u riziku od malnutricije, bolesnike s nedavnim kardiovaskularnim događajima te bolesnike s umjerenim do ozbiljnim kognitivnim oštećenjem, bili su isključeni iz ispitivanja.
English: This was also confirmed in an 8-week study versus liraglutide, administered before breakfast, in combination with insulin glargine with or without metformin.
Croatian: Ovo je također potvrđeno u 8-tjednom ispitivanju u kojem su se uspoređivali liksisenatid i liraglutid, primijenjeni prije doručka u kombinaciji s inzulinom glarginom, s ili bez metformina.
English: • Do not activate the purple 20 microgram Lyxumia pen until you have finished the green pen.
Croatian: • Nemojte aktivirati ljubičastu Lyxumia brizgalicu od 20 mikrograma dok ne upotrijebite sve doze iz zelene brizgalice.
English: The ELIXA study was a randomized, double-blind, placebo-controlled, multinational study that evaluated cardiovascular (CV) outcomes during treatment with lixisenatide in patients with type 2 diabetes mellitus after a recent Acute Coronary Syndrome.
Croatian: ELIXA ispitivanje bilo je randomizirano, dvostruko slijepo, placebom kontrolirano, multinacionalno ispitivanje koje je procijenilo kardiovaskularne (KV) ishode tijekom liječenja liksisenatidom u bolesnika sa šećernom bolešću tipa 2 koji su nedavno imali akutni koronarni sindrom.
English: The GLP-1 receptor is the target for native GLP-1, an endogenous incretin hormone that potentiates glucose-dependent insulin secretion from the pancreatic beta cells.
Croatian: GLP-1 receptor je ciljno mjesto za prirodni GLP-1, endogeni inkretinski hormon koji pojačava o glukozi ovisno lučenje inzulina iz beta stanica gušterače.
English: Over 2,600 patients have received Lyxumia either alone or in combination with metformin, a sulphonylurea (with or without metformin) or a basal insulin (with or without metformin, or with or without a sulphonylurea) in 8 large placebo- or active-controlled phase III studies.
Croatian: Više od 2600 bolesnika primalo je lijek Lyxumia samostalno ili u kombinaciji s metforminom, sulfonilurejom (sa ili bez metformina) ili bazalnim inzlinom (sa ili bez metformina , ili sa ili bez sulfonilureje) u 8 velikih ispitivanja faze III kontroliranih placebom ili aktivnim kontrolnim lijekom.
English: Pull the needle out of your skin.
Croatian: Izvucite iglu iz kože.
English: During the 12-week run-in period, addition and titration of insulin glargine resulted approximately in an HbA1c decrease of 1%.
Croatian: Tijekom 12-tjednog uvodnog razdoblja dodatak i titriranje inzulina glargina rezultiralo je smanjenjem vrijednosti HbA1c od približno 1%.
English: After multiple dose administration in patients with type 2 diabetes, mean terminal half-life was approximately 3 hours and the mean apparent clearance (CL/F) about 35 L/h.
Croatian: Nakon primjene višekratnih doza u bolesnika sa šećernom bolešću tipa 2 srednja vrijednost terminalnog poluvijeka bila je približno 3 sata, a prividni srednji klirens (CL/F) približno 35 l/h.
English: Following administration of a single dose of an oral contraceptive medicinal product (ethinylestradiol 0.03 mg/levonorgestrel 0.15 mg) 1 hour before or 11 hours after 10 mcg lixisenatide, the Cmax, AUC, t1/2 and tmax of ethinylestradiol and levonorgestrel were unchanged.
Croatian: Nakon primjene jednokratne doze oralnog kontraceptivnog lijeka (etinilestradiol 0,03 mg/levonorgestrel 0,15 mg) 1 sat prije ili 11 sati nakon primjene 10 µg liksisenatida, Cmax, AUC, t1/2 i tmax etinilestradiola i levonorgestrela ostali su nepromijenjeni.
English: There are no clinically relevant differences in the rate of absorption when lixisenatide is administered subcutaneously in the abdomen, thigh, or arm.
Croatian: Nema klinički značajnih razlika u brzini apsorpcije kada se liksisenatid primjenjuje supkutano u abdomen, bedro ili ruku.
English: Lixisenatide has not been studied in patients with severe gastrointestinal disease, including severe gastroparesis and therefore, the use of lixisenatide is not recommended in these patients.
Croatian: Liksisenatid nije ispitivan u bolesnika s teškom gastrointestinalnom bolešću, uključujući tešku gastroparezu, pa se stoga primjena liksisenatida u tih bolesnika ne preporučuje.
English: Lixisenatide should be used with caution in patients receiving oral medicinal products that require rapid gastrointestinal absorption, require careful clinical monitoring or have a narrow therapeutic ratio.
Croatian: Liksisenatid se mora primjenjivati s oprezom u bolesnika koji uzimaju peroralne lijekove koji zahtijevaju brzu gastrointestinalnu apsorpciju, pomno kliničko praćenje ili koji imaju uzak terapijski indeks.
English: Overall, 6068 patients were randomized 1:1 to either placebo or lixisenatide 20 mcg (following a starting dose of 10 mcg during the first 2 weeks).
Croatian: Sveukupno, 6068 bolesnika bilo je randomizirano 1:1 na placebo ili liksisenatid 20 µg (nakon početne doze od 10 µg tijekom prva 2 tjedna).
English: Restoration of first phase insulin secretion and improved second phase insulin secretion in response to an intravenous bolus of glucose were demonstrated in patients with type 2 diabetes (n=20) after a single dose of Lyxumia.
Croatian: Obnova prve faze lučenja inzulina i poboljšana druga faza lučenja inzulina kao odgovor na intravensku bolusnu injekciju glukoze pokazane su u bolesnika sa šećernom bolešću tipa 2 (n=20) nakon jednokratne doze lijeka Lyxumia.
English: Pack sizes of 1, 2 or 6 pre-filled pens.
Croatian: Veličine pakiranja: 1, 2 ili 6 napunjenih brizgalica.
English: When administered once daily, lixisenatide improves glycaemic control through the immediate and sustained effects of lowering both post-prandial and fasting glucose concentrations in patients with type 2 diabetes.
Croatian: Kada se primjenjuje jedanput na dan, liksisenatid poboljšava kontrolu glikemije kroz trenutne i održane učinke snižavanja koncentracija glukoze nakon obroka i natašte u bolesnika sa šećernom bolešću tipa 2.
English: MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS PEN LABEL
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE NALJEPNICA BRIZGALICE
English: 1 pre-filled pen of 3 ml (14 doses) 2 pre-filled pens of 3 ml (2x14 doses) 6 pre-filled pens of 3 ml (6x14 doses)
Croatian: 1 napunjena brizgalica od 3 ml (14 doza) 2 napunjene brizgalice od 3 ml (2x14 doza) 6 napunjenih brizgalica od 3 ml (6x14 doza)
English: Irrespective of the dose and whether lixisenatide was administered as single or multiple doses, the median tmax is 1 to 3.5 hours in patients with type 2 diabetes.
Croatian: Neovisno o dozi i o tome primjenjuje li se liksisenatid u obliku jedne ili više doza, medijan tmax u bolesnika sa šećernom bolešću tipa 2 iznosi 1-3,5 sati.
English: Keep the injection button pressed in and slowly count to 5 in order to expel the last drops.
Croatian: Držite dugme za injiciranje pritisnutim i polako brojite do 5 kako biste izbacili i posljednje kapljice.
English: Pull the needle out of your skin and remove the needle from the pen.
Croatian: Izvucite iglu iz kože i uklonite je s brizgalice.
English: These medicinal products should be taken in a standardised way in relation to lixisenatide.
Croatian: Navedene lijekove treba uzimati na uobičajen način u odnosu na liksisenatid.
English: Inject Lyxumia in the hour before any meal of the day.
Croatian: Injicirajte lijek Lyxumia unutar sat vremena prije bilo kojeg dnevnog obroka.
English: No such increase for tmax was observed when atorvastatin was administered in the evening and lixisenatide in the morning but the AUC and Cmax of atorvastatin were increased by 27% and 66%, respectively.
Croatian: Takvo povećanje vrijednosti tmax nije primijećeno kada je atorvastatin primijenjen navečer, a liksisenatid ujutro, ali se AUC atorvastatina povećao za 27%, a Cmax za 66%.
English: Keep the injection button pressed in and slowly count to 5 to get the full dose.
Croatian: Držite dugme za injiciranje pritisnutim i polako brojite do 5 kako biste injicirali cijelu dozu.
English: Table of activation and disposal
Croatian: Tablica za aktivaciju i zbrinjavanje
English: Important information about some of the ingredients of Lyxumia This medicine contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially “sodium-free”.
Croatian: Važne informacije o nekim sastojcima lijeka Lyxumia Ovaj lijek sadrži manje od 1 mmol natrija (23 mg) po dozi, tj. zanemarive količine natrija.
English: Lixisenatide stimulates insulin secretion when blood glucose is increased but not at normoglycaemia, which limits the risk of hypoglycaemia.
Croatian: Liksisenatid potiče lučenje inzulina kada je povišena koncentracija glukoze u krvi, ali ne i u slučaju normoglikemije, što ograničava rizik od hipoglikemije.
English: Efficacy of Lyxumia was also assessed in two randomised, open-label, active-controlled study (versus exenatide or versus insulin glulisine) and in a meal time study (in total 1,067 patients randomised to lixisenatide).
Croatian: Djelotvornost lijeka Lyxumia također je ocijenjena u dva randomizirana, otvorena, aktivno kontrolirana ispitivanja (naspram eksenatida ili naspram inzulina glulizina) te u jednom ispitivanju za vrijeme jela (ukupno 1067 bolesnika randomiziranih na liksisenatid).
English: Keep it straight as you screw it on.
Croatian: Iglu držite ravno dok je navijate na brizgalicu.
English: These changes are not clinically relevant and therefore, no dose adjustment for atorvastatin is required when co-administered with lixisenatide.
Croatian: Te promjene nisu klinički značajne i stoga nije potrebna prilagodba doze atorvastatina pri istodobnoj primjeni s liksisenatidom.
English: Insulin glulisine QD
Croatian: Inzulin glulizin QD
English: After 12-week of optimal insulin glargine titration with or without metformin, inadequately controlled patients were randomised to add single dose of lixisenatide or a single dose (QD) of insulin glulisine (both before the largest meal) or insulin glulisine administered three times a day (TID) for 26 weeks.
Croatian: Nakon 12 tjedana titracije inzulina glargina do optimalne doze uz metformin ili bez njega, bolesnici s nezadovoljavajućom kontrolom bolesti randomizirani su kako bi im se dodala jedna doza dnevno liksisenatida ili jedna doza dnevno (QD) inzulina glulizina (u oba slučaja prije najvećeg obroka) ili inzulin glulizin primijenjen tri puta na dan (TID) tijekom 26 tjedana.
English: Before first use Store in a refrigerator (2°C-8°C).
Croatian: Prije prve uporabe Čuvati u hladnjaku (2°C-8°C).
English: Table 1: Adverse reactions reported in placebo- and active-controlled phase III studies during the entire treatment period (including the period beyond the main 24-week treatment period in studies with ≥76 weeks of total treatment).
Croatian: Tablica 1: nuspojave prijavljene u ispitivanjima faze III kontroliranim placebom ili aktivnim kontrolnim lijekom tijekom cijelog razdoblja liječenja (uključujući razdoblje nakon osnovnog 24-tjednog liječenja u ispitivanjima u kojima je liječenje ukupno trajalo ≥ 76 tjedana).
English: Lyxumia is indicated for the treatment of adults with type 2 diabetes mellitus to achieve glycaemic control in combination with oral glucose-lowering medicinal products and/or basal insulin when these, together, with diet and exercise, do not provide adequate glycaemic control (see sections 4.4 and 5.1 for available data on the different combinations).
Croatian: Lyxumia je indicirana za liječenje odraslih sa šećernom bolešću tipa 2 za postizanje kontrole glikemije u kombinaciji s oralnim lijekovima za snižavanje razine glukoze u krvi i/ili bazalnim inzulinom kada ti lijekovi u kombinaciji s dijetom i tjelovježbom ne omogućuju odgovarajuću kontrolu glikemije (vidjeti dijelove 4.4 i 5.1 za dostupne podatke o različitim kombinacijama).
English: Of lixisenatide-treated patients with HbA1c measurement, 79.3% had either a negative antibody status or an antibody concentration below the lower limit of quantification and the other 20.7% of patients had a quantified antibody concentration.
Croatian: Od bolesnika liječenih liksisenatidom u kojih je mjerena vrijednost HbA1c, njih 79,3% imalo je ili negativan status protutijela ili koncentraciju protutijela ispod donje granice mjerljivosti, dok je ostalih 20,7% bolesnika imalo mjerljivu koncentraciju protutijela.
English: • Activate the pen on the same day as your first injection
Croatian: • Aktivirajte brizgalicu na dan primjene prve injekcije
English: People aged ≥70 years The efficacy and safety of lixisenatide in people aged ≥70 years with type 2 diabetes was evaluated in a double-blind, placebo-controlled study of 24 weeks duration.
Croatian: Djelotvornost i sigurnost primjene liksisenatida u osoba u dobi od ≥70 godina sa šećernom bolešću tipa 2 procijenjene su u dvostruko slijepom, placebom kontroliranom ispitivanju u trajanju od 24 tjedna.
English: The addition of lixisenatide led to a significantly greater HbA1c decrease of 0.71% in the lixisenatide group compared to 0.40% in the placebo group.
Croatian: Dodatak liksisenatida doveo je do značajno većeg smanjenja vrijednosti HbA1c od 0,71% u skupini na liksisenatidu u usporedbi sa smanjenjem od 0,40% u skupini na placebu.
English: The green 10 micrograms Lyxumia pen is empty when the black plunger has reached ‘0' on the dose scale and the injection button cannot be pulled out fully.
Croatian: Zelena Lyxumia brizgalica od 10 mikrograma prazna je kada crni klip dosegne oznaku ‘0' na skali za doziranje, a dugme za injiciranje se više ne može izvući do kraja.
English: • Replace the pen cap after each use in order to protect from light.
Croatian: • Vratite zatvarač na brizgalicu nakon svake uporabe radi zaštite od svjetlosti.
English: • If you think your Lyxumia pen may be damaged, do not use it. Get a new one.
Croatian: • Ako mislite da bi Lyxumia brizgalica mogla biti oštećena, nemojte je upotrijebiti.
English: Always use a new needle for activation.
Croatian: Za aktivaciju uvijek upotrijebite novu iglu.
English: In subjects with mild (creatinine clearance calculated by the Cockcroft-Gault formula 60-90 ml/min), moderate (creatinine clearance 30-60 ml/min) and severe renal impairment (creatinine clearance 1530 ml/min) AUC was increased by 46%, 51% and 87%, respectively.
Croatian: U ispitanika s blagim (klirens kreatinina 60-90 ml/min izračunat prema Cockcroft-Gaultovoj formuli), umjerenim (klirens kreatinina 30-60 ml/min) i teškim oštećenjem funkcije bubrega (klirens kreatinina 15-30 ml/min) AUC je bio povećan za 46%, 51% i 87%.
English: Efficacy and safety of Lyxumia in patients older than 70 years was addressed in a specifically dedicated placebo-controlled study (176 patients randomised to lixisenatide, including 62 patients ≥75 years of age).
Croatian: Djelotvornost i sigurnost primjene lijeka Lyxuma u bolesnika starijih od 70 godina bila je ispitivana u posebno namijenjenom placebom kontroliranom ispitivanju (176 bolesnika randomiziranih na liksisenatid, uključujući 62 bolesnika u dobi od ≥ 75 godina).
English: Gastro-resistant formulations containing substances sensitive to stomach degradation, should be administered 1 hour before or 4 hours after lixisenatide injection.
Croatian: Želučanootporne formulacije koje sadrže tvari osjetljive na razgradnju u želucu moraju se primijeniti 1 sat prije ili 4 sata nakon injekcije liksisenatida.
English: Do not use Lyxumia - if you are allergic to lixisenatide or any of the other ingredients of this medicine (listed in section 6).
Croatian: Što morate znati prije nego počnete primjenjivati lijek Lyxumia Nemojte primjenjivati lijek Lyxumia: - ako ste alergični na liksisenatid ili neki drugi sastojak ovoga lijeka (naveden u dijelu 6).
English: Uncommon side effect: may affect up to 1 in 100 people • Hives (urticaria)
Croatian: Manje česte nuspojave: mogu se javiti u manje od 1 na 100 osoba • koprivnjača (urtikarija)
English: Sanofi-Aventis Deutschland GmbH Industriepark Höchst - 65926 Frankfurt am Main Germany
Croatian: Sanofi-Aventis Deutschland GmbH Industriepark Höchst - 65926 Frankfurt am Main Njemačka
English: Maintenance dose: a fixed maintenance dose of 20 mcg lixisenatide once daily is started on Day 15.
Croatian: Doza održavanja: fiksna doza održavanja od 20 µg liksisenatida jedanput na dan počinje se primjenjivati 15.-og dana.
English: The HbA1c reduction was significant with once daily administration, whether administered morning or evening.
Croatian: Smanjenje HbA1c bilo je značajno kod primjene lijeka jedanput na dan, neovisno o tome je li se primjenjivao ujutro ili navečer.
English: In the completed Phase III studies, it was observed that approximately 90% of the patients were able to remain on the once daily maintenance dose of 20 mcg Lyxumia at the end of the main 24-week treatment period.
Croatian: U završenim ispitivanjima faze III opaženo je da je na kraju osnovnog 24-tjednog razdoblja liječenja otprilike 90% bolesnika moglo ostati na dozi održavanja lijeka Lyxumia od 20 µg jedanput na dan.
English: Ask your doctor, pharmacist or nurse which needle gauge and length is best for you.
Croatian: Pitajte liječnika, ljekarnika ili medicinsku sestru koja je veličina i duljina igle najbolja za Vas.
English: Type I glass cartridge with a (bromobutyl) rubber plunger, flanged caps (aluminium) with inserted laminated sealing disks (bromobutyl rubber on the inside and polyisoprene on the outside).
Croatian: I s gumenim klipom (brombutil) te zatvaračem s rubnikom (aluminij) i umetnutim laminiranim zaštitnim pločicama (brombutilna guma sa strane okrenute prema unutra i poliizopren s vanjske strane).
English: This helps prevent contamination of Lyxumia or possible needle blockage.
Croatian: Na taj se način sprečava onečišćenje lijeka Lyxumia ili moguće začepljenje igle.
English: When used in combination with a sulphonylurea or a basal insulin, patients should be advised to take precautions to avoid hypoglycaemia while driving and using machines.
Croatian: Kada se primjenjuje u kombinaciji sa sulfonilurejom ili bazalnim inzulinom, bolesnicima treba savjetovati da poduzmu mjere opreza kako bi izbjegli hipoglikemiju tijekom upravljanja vozilima ili rada sa strojevima.
English: There is no therapeutic experience with lixisenatide in patients with type 1 diabetes mellitus and it should not be used in these patients.
Croatian: Nema terapijskog iskustva s liksisenatidom u bolesnika sa šećernom bolešću tipa 1, stoga se lijek ne smije primjenjivati u tih bolesnika.
English: Median treatment duration was 22.4 months in the lixisenatide group and 23.3 months in the placebo group, and the median duration of study follow-up was 25.8 and 25.7 months, respectively.
Croatian: Medijan trajanja liječenja bio je 22,4 mjeseca za skupinu liječenu liksisenatidom i 23,3 mjeseca za placebo skupinu, a medijan trajanja ispitivanja praćenja bio je 25,8 mjeseci za skupinu liječenu s liksisenatidom i 25,7 mjeseci za placebo skupinu.