FrancophonIA/ELRC3.0 huggingface dataset:
English: 2 rue du Colonel Lilly 67640 Fegersheim France
Croatian: 2 rue du Colonel Lilly 67640 Fegersheim Francuska
English: Efficacy and safety were measured from the time of randomisation after completion of first line (induction) therapy.
Croatian: Djelotvornost i sigurnost mjereni su od randomizacije nakon završetka prve linije liječenja (uvodnog liječenja).
English: a Statistically significant for noninferiority, with the entire confidence interval for HR well below the 1.17645 noninferiority margin (p <0.001).
Croatian: a Statistički značajan za neinferiornost, a cijeli interval pouzdanosti za HR nalazi se znatno ispod granice neinferiornosti od 1,17645 (p < 0,001).
English: Taking into account the PRAC Assessment Report on the PSUR(s) for pemetrexed, the scientific conclusions of the CHMP are as follows:
Croatian: Uzimajući u obzir PRAC-ovo izvješće o ocjeni periodičkog(ih) izvješća o neškodljivosti lijeka (PSUR) za pemetreksed, znanstveni zaključci CHMP-a su sljedeći:
English: In Vitro studies indicate that pemetrexed is actively secreted by OAT3 (organic anion transporter.
Croatian: Ispitivanja in vitro pokazuju da se pemetreksed aktivno izlučuje putem OAT3 (organskog anionskog transportera).
English: When using ALIMTA in combination with cisplatin:
Croatian: Kad se ALIMTA primjenjuje u kombinaciji s cisplatinom:
English: Pemetrexed should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus (see section 4.4).
Croatian: Pemetreksed se ne smije primjenjivati u trudnoći, osim ako je to doista nužno i tek nakon što se pažljivo razmotre potrebe majke i mogući rizik za plod (vidjeti dio 4.4).
English: If you are unsure, ask your doctor or pharmacist if any of your medicines are NSAIDs.
Croatian: Ako niste sigurni, pitajte svog liječnika ili ljekarnika je li koji od Vaših lijekova
English: Response (n: qualified for response) Response rate (%) (95 % CI) Stable disease (%)
Croatian: Odgovor (n: broj bolesnika u kojih se mogao ocijeniti odgovor) stopa odgovora (%) (95% CI) stabilna bolest (%)
English: Taste change
Croatian: Promjena okusa
English: Pre-treatment with dexamethasone (or equivalent) can reduce the incidence and severity of skin reactions (see section 4.2).
Croatian: Prethodnim davanjem deksametazona (ili ekvivalentnog lijeka) mogu se smanjiti incidencija i težina kožnih reakcija (vidjeti dio 4.2).
English: Particular attention should be paid to these patients and caution exercised with use of other radiosensitising agents.
Croatian: Treba obratiti posebnu pozornost na te bolesnike i uz oprez primjenjivati druge lijekove koji povećavaju osjetljivost na zračenje.
English: The total bilirubin should be ≤ 1.5 times upper limit of normal.
Croatian: Vrijednost ukupnog bilirubina mora biti ≤ 1,5 puta iznad gornje granice normalnih vrijednosti.
English: There are no data from the use of pemetrexed in pregnant women but pemetrexed, like other anti-metabolites, is suspected to cause serious birth defects when administered during pregnancy.
Croatian: Nema podataka o primjeni pemetrekseda u trudnica, no sumnja se da pemetreksed, kao i ostali antimetaboliti, uzrokuje teške prirođene mane ako se primjenjuje tijekom trudnoće.
English: You will always receive ALIMTA by infusion into one of your veins.
Croatian: Lijek ALIMTA uvijek ćete primiti infuzijom u jednu od vena.
English: The European Medicines Agency has waived the obligation to submit the results of studies with ALIMTA in all subsets of the paediatric population in the granted indications (see Section 4.2).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka ALIMTA u svim podskupinama pedijatrijske populacije za odobrene indikacije (vidjeti dio 4.2).
English: You will also receive an injection of vitamin B12 (1000 micrograms) in the week before administration of ALIMTA and then approximately every 9 weeks (corresponding to 3 courses of ALIMTA treatment).
Croatian: Također ćete dobiti injekciju vitamina B12 (1000 mikrograma) u tjednu prije primjene lijeka ALIMTA i zatim otprilike svakih 9 tjedana (što odgovara 3 ciklusa liječenja lijekom ALIMTA).
English: You must contact your doctor immediately if you notice any of the following: Fever or infection (common): if you have a temperature of 38ºC or greater, sweating or other signs of infection(since you might have less white blood cells than normal which is very common).
Croatian: Morate se odmah javiti svom liječniku ako primijetite bilo što od sljedećeg: vrućicu ili infekciju (često): ako Vam je tjelesna temperatura 38°C ili viša, ako se znojite ili imate neke druge znakove infekcije (jer broj bijelih krvnih stanica može biti niži od normalnog,
English: Alkaline phosphatase (AP), aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT) should be ≤ 3 times upper limit of normal.
Croatian: Vrijednosti alkalne fosfataze (ALP), aspartat aminotransferaze (AST ili SGOT) i alanin aminotransferaze (ALT ili SGPT) moraju biti ≤ 3 puta iznad gornje granice normalnih vrijednosti.
English: What ALIMTA contains
Croatian: Što ALIMTA sadrži
English: Efficacy of ALIMTA vs docetaxel in NSCLC - ITT population ALIMTA
Croatian: Djelotvornost lijeka ALIMTA u odnosu na docetaksel kod NSCLC - ITT populacija ALIMTA
English: Log Rank p-value*
Croatian: Log-rang p-vrijednost*
English: Common Pain Edema Renal Disorders Common Renal disorders**** Abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; CTCAE = Common Terminology Criteria for Adverse Event; NCI = National Cancer Institute; SGOT = serum glutamic oxaloacectic aminotransferase; SGPT = serum glutamic pyruvic aminotransferase.
Croatian: Kratice: ALT = alanin aminotransferaza; AST = aspartat aminotransferaza; CTCAE = Zajednička terminologija za nuspojave; NCI = Nacionalni institut za rak; SGOT = serumska glutamat-oksaloctena aminotransferaza; SGPT = serumska glutamat piruvična aminotransferaza.
English: Kaplan Meier plots of overall survival by histology
Croatian: Kaplan Meierove krivulje ukupnog preživljenja prema histološkom tipu tumora
English: If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive ALIMTA.
Croatian: Ako trenutno imate ili ste prethodno imali problema s bubrezima, obratite se svom liječniku ili bolničkom ljekarniku jer možda nećete smjeti primati lijek ALIMTA.
English: You must take at least 5 doses during the seven days before the first dose of ALIMTA.
Croatian: Morate uzeti barem 5 doza tijekom 7 dana prije prve doze lijeka ALIMTA.
English: Pemetrexed N = 265
Croatian: Pemetreksed N = 265
English: Alimta can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Croatian: ALIMTA Vam se može propisati ako imate rak pluća u uznapredovaloj fazi i ako je Vaša bolest reagirala na liječenje ili ostala uglavnom nepromijenjena nakon početne kemoterapije.
English: Fisher's exact p-value*
Croatian: Fisherova egzaktna p-vrijednost
English: Therefore, patients should receive adequate antiemetic treatment and appropriate hydration prior to and/or after receiving treatment.
Croatian: Iz tog razloga bolesnici moraju primiti odgovarajući antiemetik i prikladnu hidrataciju prije i/ili nakon primjene terapije.
English: 75 % of previous dose (both ALIMTA and cisplatin)
Croatian: 75% prethodne doze (i lijeka ALIMTA i cisplatina)
English: Prior chemotherapy did not include ALIMTA.
Croatian: Prethodna kemoterapija nije uključivala lijek ALIMTA.
English: Dose of ALIMTA (mg/m2)
Croatian: Doza lijeka ALIMTA (mg/m2)
English: On the basis of the scientific conclusions for pemetrexed the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing pemetrexed is unchanged subject to the proposed changes to the product information
Croatian: Na temelju znanstvenih zaključaka za pemetreksed, CHMP smatra da je omjer koristi i rizika lijeka(ova) koji sadrži(e) pemetreksed nepromijenjen, uz predložene izmjene informacija o lijeku.
English: The independent review of patient scans confirmed the findings of the investigator assessment of PFS.
Croatian: Neovisna procjena snimaka bolesnika potvrdila je zaključke ispitivača pri procjeni PFS
English: As a result, concomitant use of live attenuated vaccines is not recommended (see section 4.3 and 4.5).
Croatian: Stoga se ne preporučuje istodobna primjena živih atenuiranih cjepiva (vidjeti dijelove 4.3 i 4.5).
English: First line doublet therapy containing ALIMTA was not included.
Croatian: Nije bila uključena prva linija dvojne terapije koja je sadržavala lijek ALIMTA.
English: Concomitant use not recommended: Live attenuated vaccines (except yellow fever, for which concomitant use is contraindicated): risk of systemic, possibly fatal, disease.
Croatian: Ne preporučuje se istodobna primjena živih atenuiranih cjepiva (osim cjepiva protiv žute groznice, čija je istodobna primjena kontraindicirana), zbog rizika od sustavne bolesti koja može biti smrtonosna.
English: Before each infusion you will have samples of your blood taken to evaluate if you have sufficient kidney and liver function and to check that you have enough blood cells to receive ALIMTA.
Croatian: Prije svake infuzije uzet će Vam se uzorak krvi kako bi se provjerilo jesu li Vam bubrežna ili jetrena funkcija dovoljno dobre i imate li dovoljno krvnih stanica da biste primili lijek ALIMTA.
English: Patients with renal impairment (Standard Cockcroft and Gault formula or Glomerular Filtration Rate measured Tc99m-DPTA serum clearance method)
Croatian: Bolesnici s oštećenjem bubrega (serumski klirens izračunat standardnom Cockcroftovom i Gaultovom formulom ili metodom mjerenja brzine glomerularne filtracije Tc99m-DPTA)
English: Frequency estimate: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1000 to <1/100), Rare (≥1/10,000 to <1/1000), Very rare (<1/10,000) and not known (cannot be estimated from available data).
Croatian: rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: A significant increase in the incidence of possibly study-drug-related Grade 3/4 neutropenia was observed with longer exposure to pemetrexed (≤6 cycles: 3.3%, > 6cycles: 6.4%: p=0.046).
Croatian: Zabilježeno je značajno povećanje incidencije neutropenije stupnja 3/4, koja je mogla biti povezana s lijekom, pri duljoj izloženosti pemetreksedu (≤ 6 ciklusa: 3,3%, > 6 ciklusa: 6,4%; p = 0,046).
English: Concomitant use contraindicated: Yellow fever vaccine: risk of fatal generalised vaccinale disease (see section 4.3).
Croatian: Kontraindicirana je istodobna primjena cjepiva protiv žute groznice zbog rizika od smrtonosne generalizirane vakcinalne bolesti (vidjeti dio 4.3).
English: Pemetrexed is primarily eliminated in the urine, with 70 % to 90 % of the administered dose being recovered unchanged in urine within the first 24 hours following administration.
Croatian: Lijek se prvenstveno eliminira mokraćom, pri čemu se 70% do 90% primijenjene doze nađe u mokraći u nepromijenjenu obliku tijekom prva 24 sata nakon primjene.
English: Patients must also receive an intramuscular injection of vitamin B12 (1000 micrograms) in the week preceding the first dose of pemetrexed and once every three cycles thereafter.
Croatian: Bolesnici moraju također primiti i intramuskularnu injekciju vitamina B12 (1000 mikrograma) u tjednu prije prve doze pemetrekseda te nakon toga jedanput svaka tri ciklusa.
English: Upset stomach
Croatian: Bol u trbuhu
English: Dose for cisplatin (mg/m2)
Croatian: Doza cisplatina (mg/m2)
English: The use of ALIMTA should be avoided during pregnancy.
Croatian: Primjena lijeka ALIMTA mora se izbjegavati tijekom trudnoće.
English: Contact your doctor if you get a severe rash, or itching, or blistering (Stevens-Johnson Syndrome or Toxic epidermal necrolysis).
Croatian: Obratite se liječniku ako dobijete težak osip, svrbež ili mjehuriće na koži (StevensJohnsonov sindrom ili toksična epidermalna nekroliza).
English: It is a white to either light yellow or green-yellow lyophilised powder.
Croatian: To je bijeli do svijetložuti ili zeleno žuti liofilizirani prašak.
English: Conjunctivitis (inflamed eye)
Croatian: Konjunktivitis (upala oka)
English: Thus, drainage of third space fluid collection prior to pemetrexed treatment should be considered, but may not be necessary.
Croatian: Stoga prije početka liječenja pemetreksedom treba razmotriti drenažu tekućine iz transcelularnog prostora, no ona možda neće biti nužna.
English: Hair loss
Croatian: Gubitak kose
English: Reconstituted and Infusion Solutions: The product should be used immediately.
Croatian: Pripremljena otopina i otopina za infuziju: Lijek se mora odmah upotrijebiti.
English: If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with ALIMTA.
Croatian: Ako ste nedavno cijepljeni, obavijestite o tome svog liječnika jer to može izazvati štetne učinke uz primjenu lijeka ALIMTA.
English: White to either light yellow or green-yellow lyophilised powder.
Croatian: Bijeli do svijetložuti ili zeleno-žuti liofilizirani prašak.
English: Prior to each chemotherapy administration blood chemistry tests should be collected to evaluate renal and hepatic function.
Croatian: Prije svake kemoterapije moraju se provesti laboratorijske krvne pretrage kako bi se ocijenila funkcija bubrega i jetre.
English: Overall response rate** (95 % CI)
Croatian: Stopa ukupnog odgovora** (95% CI)
English: No statistically significant differences in any other individual Grade 3/4/5 adverse reactions were seen with longer exposure.
Croatian: Nisu uočene statistički značajne razlike između skupina za bilo koju drugu pojedinačnu nuspojavu stupnjeva 3/4/5
English: The analysis of the impact of NSCLC histology on overall survival demonstrated clinically relevant differences in survival according to histology, see table below.
Croatian: Analiza utjecaja histologije NSCLC-a na ukupno preživljenje pokazala je klinički značajnu razliku u preživljenju s obzirom na histološki tip tumora, vidjeti tablicu ispod.
English: 75 % of previous dose
Croatian: 75% prethodne doze
English: Pain, redness, swelling or sores in your mouth Nausea
Croatian: Bol, crvenilo, oteklina ili ranice u ustima
English: Do not use ALIMTA - if you are allergic (hypersensitive) to pemetrexed or any of the other ingredients of of this medicine (listed in section 6).
Croatian: - ako ste alergični (preosjetljivi) na pemetreksed ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: There have been a few reported cases of pemetrexed extravasation, which were not assessed as serious by the investigator.
Croatian: Prijavljeno je nekoliko slučajeva ekstravazacije pemetrekseda koje ispitivači nisu ocijenili ozbiljnima.
English: rue du Colonel Lilly F-67640 Fegersheim France
Croatian: Lilly France S.A.S. rue du Colonel Lilly F-67640 Fegersheim Francuska
English: You must continue taking the folic acid for 21 days after the last dose of ALIMTA.
Croatian: Morate nastaviti uzimati folatnu kiselinu još najmanje 21 dan nakon posljednje doze lijeka ALIMTA.
English: Superiority p-value
Croatian: p-vrijednost za superiornost
English: 100 % of previous dose
Croatian: 100% prethodne doze
English: Calculate the dose and the number of ALIMTA vials needed.
Croatian: Izračunajte dozu i potreban broj bočica lijeka ALIMTA.
English: ALIMTA should be administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Croatian: ALIMTA se mora primjenjivati u obliku intravenske infuzije u trajanju od 10 minuta prvog dana svakog 21-dnevnog ciklusa.
English: If you have an accumulation of fluid around your lungs, your doctor may decide to remove the fluid before giving you ALIMTA.
Croatian: Ako Vam se oko pluća nakupila tekućina, liječnik može odlučiti ukloniti tu tekućinu prije primjene lijeka ALIMTA.
English: Therefore, the use of pemetrexed in patients with creatinine clearance of < 45 ml/min is not recommended (see section 4.2).
Croatian: Stoga se primjena pemetrekseda u bolesnika s klirensom kreatinina < 45 ml/min ne preporučuje (vidjeti dio 4.2).
English: This is further supported with data from a clinical study.
Croatian: Gore navedeno dodatno potkrjepljuju podaci iz kliničkog ispitivanja.
English: Blood clots in the lung blood vessels (pulmonary embolism)
Croatian: Krvni ugrušci u krvnim žilama u plućima (plućna embolija)
English: The resulting solution is clear and ranges in colour from colourless to yellow or green-yellow without adversely affecting product quality.
Croatian: Dobivena otopina je bistra i u rasponu boja od bezbojne do žute ili zeleno-žute što ne utječe nepovoljno na kvalitetu lijeka. pH
English: Increased skin pigmentation
Croatian: Suzenje očiju Pojačana pigmentacija kože
English: The pharmacokinetic properties of pemetrexed following single-agent administration have been evaluated in 426 cancer patients with a variety of solid tumours at doses ranging from 0.2 to 838 mg/m2 infused over a 10-minute period.
Croatian: 5.2 Farmakokinetička svojstva Farmakokinetička svojstva pemetrekseda nakon primjene u monoterapiji ispitana su u 426 onkoloških bolesnika s različitim solidnim tumorima, pri dozama od 0,2 do 838 mg/m2 primijenjenima u infuziji tijekom 10 minuta.
English: INFORMATION ON BRAILLE
Croatian: 16. PODACI NA BRAILLEOVOM PISMU
English: Owing to the possibility of pemetrexed treatment causing irreversible infertility, men are advised to seek counselling on sperm storage before starting treatment.
Croatian: Budući da liječenje pemetreksedom može uzrokovati trajnu neplodnost, muškarcima se preporučuje da prije početka liječenja potraže savjet o pohrani sperme.
English: A total of 169 patients (47.1%) completed ≥ 6 cycles maintenance treatment with ALIMTA, representing at least 10 total cycles of ALIMTA.
Croatian: Ukupno je 169 (47,1%) bolesnika završilo ≥ 6 ciklusa terapije održavanja lijekom ALIMTA, što znači da su primili najmanje 10 ciklusa lijeka ALIMTA.
English: Therefore, caution should be made when administering higher doses of NSAIDs or acetylsalicylic acid, concurrently with pemetrexed to patients with normal function (creatinine clearance > 80 ml/min).
Croatian: Stoga je nužan oprez pri istodobnoj primjeni pemetrekseda i viših doza NSAIL-a ili acetilsalicilatne kiseline u bolesnika s normalnom bubrežnom funkcijom (klirens kreatinina ≥ 80 ml/min).
English: The other ingredients are mannitol, hydrochloric acid and sodium hydroxide
Croatian: Drugi sastojci su manitol, kloridna kiselina i natrijev hidroksid.
English: If you are concerned about any side effects, talk to your doctor.
Croatian: Ako ste zabrinuti zbog bilo koje nuspojave, obratite se liječniku.
English: Alkaline phosphatase, AST and ALT ≤ 5 times upper limit of normal is acceptable if liver has tumour involvement.
Croatian: Prihvatljive su vrijednosti alkalne fosfataze, AST-a i ALT-a od ≤ 5 puta iznad gornje granice normale ako je jetra zahvaćena tumorom.
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1000 micrograms) that you must take once a day while you are taking ALIMTA.
Croatian: Vitaminska nadoknada: liječnik će Vam propisati folatnu kiselinu (vitamin) koja se uzima kroz usta ili multivitaminski pripravak koji sadrži folatnu kiselinu (350 do 1000 mikrograma), koji morate uzimati jedanput na dan za vrijeme liječenja lijekom ALIMTA.
English: Fully supplemented patients patients
Croatian: Bolesnici s potpunim bolesnici nadomjeskom
English: There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore the use of pemetrexed is not recommended (see section 4.4).
Croatian: Nema dovoljno podataka o primjeni pemetrekseda u bolesnika s klirensom kreatinina manjim od 45 ml/min; stoga se u tih bolesnika ne preporučuje primjena pemetrekseda (vidjeti dio 4.4).
English: Preparation and administration precautions: As with other potentially toxic anticancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions.
Croatian: Mjere opreza pri pripremanju i primjeni: Kao i kod svih potencijalno toksičnih protutumorskih lijekova, treba biti oprezan pri rukovanju i pripremi otopine pemetrekseda za infuziju.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 20 September 2004
Croatian: Datum prvog odobrenja: 20. rujna 2004.
English: Of the randomised patients, 44.9% had a complete/partial response and 51.9% had a response of stable disease to ALIMTA plus cisplatin induction.
Croatian: Od svih randomiziranih bolesnika njih je 44,9% imalo kompletan/djelomičan odgovor na uvodno liječenje lijekom ALIMTA u kombinaciji s cisplatinom, a 51,9% njih odgovor u obliku stabilne bolesti.
English: If you have had or are going to have radiation therapy, please tell your doctor, as there may be an early or late radiation reaction with ALIMTA.
Croatian: Ako ste primali ili ćete primati terapiju zračenjem, obavijestite o tome svog liječnika jer se uz primjenu lijeka ALIMTA mogu pojaviti rane ili kasne reakcije na zračenje.
English: Patients must take oral folic acid or a multivitamin containing folic acid (350 to 1000 micrograms) on a daily basis.
Croatian: Bolesnici moraju svakodnevno peroralno uzimati folatnu kiselinu ili multivitaminski pripravak koji sadrži folatnu kiselinu (350 do 1000 mikrograma).
English: Gemcitabine/ cisplatin (N = 830)
Croatian: Gemcitabin/ Cisplatin (N = 830)
English: Breast-feeding (see section 4.6).
Croatian: Dojenje (vidjeti dio 4.6)
English: Patients received a median of 4 cycles of maintenance treatment with ALIMTA and 4 cycles of placebo.
Croatian: Bolesnici su primili medijan od 4 ciklusa terapije održavanja lijekom ALIMTA i 4 ciklusa placeba.
English: Less toxicity and reduction in Grade 3/4 haematologic and non-haematologic toxicities such as neutropenia, febrile neutropenia and infection with Grade 3/4 neutropenia were reported when pre-treatment with folic acid and vitamin B12 was administered.
Croatian: Manja toksičnost te smanjenje hematološke i nehematološke toksičnosti stupnja 3/4, poput neutropenije, febrilne neutropenije i infekcija praćenih neutropenijom stupnja 3/4 prijavljene su kada je primijenjeno prethodno liječenje folatnom kiselinom i vitaminom B12.
English: The incidence of adverse reactions was evaluated for patients who received ≤ 6 cycles of pemetrexed maintenance (N=519), and compared to patients who received > 6 cycles of pemetrexed (N=281).
Croatian: Incidencija nuspojava ocijenjena je u bolesnika koji su primili ≤ 6 ciklusa pemetrekseda kao terapije održavanja (N=519) te je uspoređena s bolesnicima koji su primili > 6 ciklusa pemetrekseda (N=281).
English: Common (may affect up to 1 in 10 people) Allergic reaction: skin rash / burning or prickling sensation Infection including sepsis
Croatian: Česte (mogu se javiti u do 1 na 10 osoba) Alergijska reakcija: kožni osip / osjećaj pečenja ili bockanja
English: An insufficient number of patients has been studied with creatinine clearance of below 45 ml/min.
Croatian: Nije ispitan dovoljan broj bolesnika s klirensom kreatinina manjim od 45 ml/min.
English: Very common (may affect more than 1 in 10 people) Low white blood cells
Croatian: Vrlo česte (mogu se javiti u više od 1 na 10 osoba) Nizak broj bijelih krvnih stanica Niska razina hemoglobina (anemija)
English: ALIMTA (pemetrexed) is a multi-targeted anti-cancer antifolate agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication.
Croatian: ALIMTA (pemetreksed) je protutumorski lijek s višestrukim antifolatnim djelovanjem koji djeluje tako da prekida ključne metaboličke procese ovisne o folatima neophodne za umnažanje stanica.
English: For instructions on reconstitution and dilution of ALIMTA before administration, see section 6.6.
Croatian: Za upute o rekonstituciji i razrjeđivanju lijeka ALIMTA prije primjene vidjeti dio 6.6.
English: Fast heart rate
Croatian: Ubrzano kucanje srca