FrancophonIA/ELRC3.0 huggingface dataset:
English: • furosemide, a medicine belonging to the type known as diuretics, which are used to increase the amount of urine you produce.
Croatian: • furosemid, lijek koji pripada vrsti koja se naziva diureticima, koji se koriste za povećanje količine mokraće koju proizvodite.
English: Neparvis is not recommended for mothers who are breastfeeding.
Croatian: Neparvis se ne preporučuje za majke koje doje.
English: • if you are more than 3 months pregnant (it is also better to avoid this medicine in early pregnancy, see “Pregnancy and breastfeeding”).
Croatian: • ako ste trudni više od 3 mjeseca (također je bolje izbjegavati ovaj lijek u ranoj trudnoći, vidjeti
English: • if you are allergic to sacubitril, valsartan or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični na sakubitril, valsartan ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Neparvis is used to treat a type of long-term heart failure in adults.
Croatian: Neparvis se koristi za liječenje jedne vrste dugotrajnog zatajenja srca u odraslih.
English: Interactions resulting in a contraindication
Croatian: Interakcije koje rezultiraju kontraindikacijom
English: No. at risk Neparvis
Croatian: Br. izloženih riziku Neparvis
English: Because of the potential risk for adverse reactions in breast-fed newborns/infants, it is not recommended during breast-feeding.
Croatian: Zbog potencijalnog rizika od nuspojava u dojene novorođenčadi/dojenčadi, on se ne preporučuje tijekom dojenja.
English: The AT1-receptor was also blocked as evidenced by increased plasma renin activity and plasma renin concentrations.
Croatian: AT1 receptor je također blokiran što je dokazano povećanom aktivnosti renina u plazmi i koncentracijama renina u plazmi.
English: If you think you may be allergic to any component of this medicine, talk to your doctor before taking Neparvis.
Croatian: Ako mislite da biste mogli biti alergični na bilo koji sastojak ovog lijeka, obratite se svom liječniku prije nego uzmete Neparvis.
English: When driving vehicles or operating machines it should be taken into account that occasionally dizziness or fatigue may occur.
Croatian: Kod upravljanja vozilima ili rada sa strojevima treba uzeti u obzir da povremeno može doći do omaglice ili umora.
English: • allergic reaction with rash and itching
Croatian: • alergijska reakcije uz osip i svrbež
English: Patients with NYHA functional classification IV
Croatian: Bolesnici sa stupnjem IV prema NYHA funkcionalnoj klasifikaciji
English: INTERMEDIATE CARTON OF MULTIPACK (WITHOUT BLUE BOX)
Croatian: SREDNJA KUTIJA VIŠESTRUKOG PAKIRANJA (BEZ PLAVOG OKVIRA)
English: Do not take Neparvis with ACE inhibitors.
Croatian: Ne uzimajte Neparvis s ACE inhibitorima.
English: A study in adult rats showed only a minimal transient inhibitory effect on bone mineral density but not on any other parameters relevant for bone growth, suggesting no relevant effect of sacubitril on bone in adult patient populations under normal conditions.
Croatian: Ispitivanje u odraslih štakora pokazalo je samo minimalan prolazan inhibitorni učinak na mineralnu gustoću kostiju, ali ne na bilo koje druge parametre relevantne za rast kostiju, što ukazuje da nema relevantnog učinka sakubitrila na kosti u populacijama odraslih bolesnika pod normalnim uvjetima.
English: Neparvis improved survival with a significant reduction in all-cause mortality of 2.8% (Neparvis, 17%, enalapril, 19.8%).
Croatian: Neparvis je poboljšao preživljenje uz značajno smanjenje smrtnosti od svih uzroka od 2,8% (Neparvis, 17%, enalapril, 19,8%).
English: Time to occurrence of CV death in PARADIGM-HF
Croatian: Vrijeme do pojave KV smrti u PARADIGM-HF-u
English: Full analysis set
Croatian: Potpuni set za analizu
English: No evidence of embryo-foetal toxicity or teratogenicity was observed in rats treated with sacubitril.
Croatian: Nisu uočeni dokazi embriofetalne toksičnosti ili teratogenosti u štakora liječenih sakubitrilom.
English: Caution should be exercised when initiating Neparvis in patients with NYHA functional classification IV due to limited clinical experience in this population.
Croatian: Potreban je oprez kada se započinje terapija Neparvisom u bolesnika sa stupnjem IV prema NYHA funkcionalnoj klasifikaciji zbog ograničenog kliničkog iskustva u toj populaciji.
English: • if you or a member of your family have ever had a reaction called angioedema (swelling of the face, lips, tongue and/or throat, difficulties in breathing) when taking an ACE inhibitor or an angiotensin receptor blocker (ARB) (such as valsartan, telmisartan or irbesartan).
Croatian: • ako ste Vi ili član Vaše obitelji ikada imali reakciju koja se zove angioedem (oticanje lica, usana, jezika i/ili grla, poteškoće s disanjem) kada ste uzimali ACE inhibitor ili blokator angiotenzinskog receptora (ARB) (kao što su valsartan, telmisartan ili irbesartan).
English: If a diuretic is also used, the risk of lithium toxicity may be increased further.
Croatian: Ako se koristi i diuretik, rizik od toksičnosti litija može se dodatno povećati.
English: If the combination proves necessary, careful monitoring of serum lithium levels is recommended.
Croatian: Ako se pokaže da je nužna primjena kombinacije, preporučuje se pažljivo praćenje razina litija u serumu.
English: Caution is therefore recommended when using it in these patients (see section 4.2 and 5.2).
Croatian: Stoga se savjetuje oprez prilikom njegove primjene u tih bolesnika (vidjeti dijelove 4.2 i 5.2).
English: Non-clinical data (including studies with sacubitril and valsartan components and/or Neparvis) reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential and fertility.
Croatian: Neklinički podaci (uključujući ispitivanja s komponentama sakubitrilom i valsartanom i/ili Neparvisom) ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti, kancerogenog potencijala i plodnosti.
English: When initiating therapy or during dose titration with Neparvis, blood pressure should be monitored routinely.
Croatian: Kada se započinje terapija ili tijekom titracije doze Neparvisa, potrebno je rutinski pratiti krvni tlak.
English: If you stop taking Neparvis
Croatian: Ako prestanete uzimati Neparvis
English: OUTER CARTON OF MULTIPACK (INCLUDING BLUE BOX)
Croatian: VANJSKA KUTIJA VIŠESTRUKOG PAKIRANJA (UKLJUČUJUĆI PLAVI OKVIR)
English: Time since randomisation (days)
Croatian: Vrijeme od randomizacije (dani)
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu
English: Sodium and/or volume depletion should be corrected before starting treatment with Neparvis, however, such corrective action must be carefully weighed against the risk of volume overload.
Croatian: Snižena razina natrija i/ili smanjeni volumen tekućine treba korigirati prije početka liječenja Neparvisom, međutim, takve korektivne mjere potrebno je pažljivo odvagnuti u odnosu na rizik od preopterećenja volumenom.
English: When pregnancy is diagnosed, treatment with ARBs should be stopped immediately and, if appropriate, alternative therapy should be started.
Croatian: Kada se trudnoća utvrdi, liječenje ARB-om treba odmah prekinuti te, ako je prikladno, započeti alternativnu terapiju.
English: The average apparent volume of distribution of valsartan and sacubitril were 75 litres to 103 litres, respectively.
Croatian: Prosječni prividni volumen distribucije valsartana i sakubitrila bio je 75 litara odnosno 103 litre.
English: The mean LVEF was 29% and there were 963 (11.4%) patients with a baseline LVEF >35% and ≤40%.
Croatian: Srednja LVEF bila je 29% i bilo je 963 (11,4%) bolesnika s početnom LVEF >35% i ≤40%.
English: • gastritis (stomach pain, nausea)
Croatian: • gastritis (bol u trbuhu, mučnina)
English: Prior to study participation, patients were well treated with standard of care therapy which included ACE inhibitors/ARBs (>99%), beta blockers (94%), mineralocorticoid antagonists (58%) and diuretics (82%).
Croatian: Prije sudjelovanja u ispitivanju bolesnici su bili dobro liječeni standardnom terapijom koja je uključivala ACE inhibitore/ARB-ove (>99%), beta blokatore (94%), mineralokortikoidne antagoniste (58%) i diuretike (82%).
English: Figure 1 Kaplan-Meier curves for the primary composite endpoint and the CV death component
Croatian: Slika 1 Kaplan-Meierove krivulje za primarni kompozitni ishod i komponentu KV smrti
English: The medicinal product is unlikely to be removed by haemodialysis due to high protein binding.
Croatian: Nije vjerojatno da će se lijek ukloniti hemodijalizom zbog visokog stupnja vezanja za proteine.
English: Neparvis may be administered with or without food (see section 5.2).
Croatian: Neparvis se može primjenjivati uz obrok ili bez njega (vidjeti dio 5.2).
English: However, a mild transient interference of sacubitril with the early phase of fracture healing in adults cannot be excluded.
Croatian: Međutim, blaga prolazna interferencija sakubitrila s ranom fazom zacjeljivanja prijeloma u odraslih ne može se isključiti.
English: Unless continued ARB therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Croatian: Ukoliko nastavak terapije ARB-om nije neophodan, bolesnice koje planiraju trudnoću treba prebaciti na alternativna antihipertenzivna liječenja koja imaju utvrđen sigurnosni profil za primjenu u trudnoći.
English: Infants whose mothers have taken ARBs should be closely observed for hypotension (see section 4.3).
Croatian: Dojenčad čije su majke uzimale ARB-ove treba pažljivo pratiti zbog hipotenzije (vidjeti dio 4.3).
English: Stopping your treatment with Neparvis may cause your condition to get worse.
Croatian: Ako prekinete liječenje Neparvisom, stanje bi Vam se moglo pogoršati.
English: Neprilysin is one of multiple enzymes involved in the clearance of amyloid-β (Aβ) from the brain and cerebrospinal fluid (CSF).
Croatian: Neprilizin je jedan od mnogih enzima uključenih u klirens amiloida-β (Aβ) iz mozga i cerebrospinalne tekućine.
English: • sildenafil, a medicine used to treat erectile dysfunction or lung hypertension.
Croatian: • sildenafil, lijek koji se koristi za liječenje erektilne disfunkcije ili plućne hipertenzije.
English: Patients randomised to the Neparvis group received treatment for a median duration of exposure of 24 months; 3,271 patients were treated for more than one year.
Croatian: Bolesnici randomizirani u Neparvis skupinu primali su terapiju uz medijan trajanja izloženosti od 24 mjeseca; 3271 bolesnik bio je liječen više od jedne godine.
English: Interactions between Neparvis and lithium have not been investigated.
Croatian: Interakcije između Neparvisa i litija nisu bile ispitivane.
English: • ACE inhibitors.
Croatian: • ACE inhibitori.
English: Treatment should not be initiated unless SBP is ≥100 mmHg.
Croatian: Liječenje se ne smije započeti dok SKT nije ≥100 mmHg.
English: Dose adjustment of diuretics, concomitant antihypertensives and treatment of other causes of hypotension (e.g. hypovolaemia) should be considered.
Croatian: Potrebno je razmotriti prilagođavanje doze diuretika, istodobno primjenjivanih antihipertenziva i liječenje drugih uzroka hipotenzije (npr. hipovolemije).
English: If you experience severe dizziness and/or fainting, tell your doctor as quickly as possible and lie down.
Croatian: Ako osjetite jaku omaglicu i/ili nesvjesticu, recite to što prije svom liječniku i legnite.
English: ACE inhibitors
Croatian: ACE inhibitori
English: Therefore, caution should be exercised when sildenafil or another PDE5 inhibitor is initiated in patients treated with Neparvis.
Croatian: Stoga je potreban oprez kada se započinje liječenje sildenafilom ili drugim PDE5 inhibitorom u bolesnika liječenih Neparvisom.
English: The use of Neparvis is not recommended during the first trimester of pregnancy and is contraindicated during the second and third trimesters of pregnancy (see section 4.3).
Croatian: Primjena Neparvisa se ne preporučuje tijekom prvog tromjesečja trudnoće te je kontraindiciran tijekom drugog i trećeg tromjesečja trudnoće (vidjeti dio 4.3).
English: Nitrates, e.g. nitroglycerine
Croatian: Nitrati, npr. nitroglicerin
English: Based on the comparison of plasma and CSF exposures, LBQ657 crosses the blood brain barrier to a limited extent (0.28%).
Croatian: Na temelju usporedbe izloženosti plazme i cerebrospinalne tekućine, LBQ657 prelazi krvno-moždanu barijeru u ograničenoj mjeri (0,28%).
English: Overall, 76% of patients achieved and maintained the target dose of Neparvis 200 mg twice daily without any dose interruption or down-titration over 12 weeks.
Croatian: Ukupno je 76% bolesnika postiglo i održalo ciljnu dozu Neparvisa 200 mg dvaput na dan bez ikakvog prekida u doziranju ili postupno sniženje doze tijekom 12 tjedana.
English: Due to discontinuations during the run-in period, the adverse reaction rates as presented in table below may be lower than the adverse reaction rates expected in clinical practice.
Croatian: Zbog isključenja iz ispitivanja tijekom ulaznog razdoblja, stope nuspojava koje su navedene u tablici u nastavku mogu biti niže od stopa nuspojava očekivanih u kliničkoj praksi.
English: The average daily dose of furosemide was unchanged from baseline until the end of the PARADIGM-HF study in patients treated with Neparvis.
Croatian: Prosječna dnevna doza furosemida bila je nepromijenjena u odnosu na početnu do kraja ispitivanja PARADIGM-HF u bolesnika liječenih Neparvisom.
English: These kidney changes represent an expected exaggerated pharmacological effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 blockers; such effects are observed if rats are treated during the first 13 days of life.
Croatian: Te promjene na bubrezima predstavljaju očekivani pretjerani farmakološki učinak inhibitora angiotenzin konvertirajućeg enzima i blokatora angiotenzina II tipa 1; takvi se učinci uočavaju ako se štakori liječe tijekom prvih 13 dana života.
English: Angioedema associated with laryngeal oedema may be fatal.
Croatian: Angioedem povezan s edemom larinksa može biti smrtonosan.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Neparvis in one or more subsets of the paediatric population in the treatment of heart failure (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Neparvis u jednoj ili više podskupina pedijatrijske populacije u liječenju zatajenja srca (vidjeti dio 4.2. za informacije o pedijatrijskoj primjeni).
English: Individual components of the primary composite endpoint CV death**
Croatian: Pojedinačne komponente primarnog kompozitnog ishoda KV smrt**
English: If any of the above applies to you, do not take Neparvis and talk to your doctor.
Croatian: Ako se bilo što od navedenoga odnosi na Vas, nemojte uzeti Neparvis i obratite se svom liječniku.
English: A similar effect on the heart rate may occur when Neparvis is co-administered with sublingual, oral or transdermal nitrates.
Croatian: Sličan učinak na srčanu frekvenciju može se javiti kada se Neparvis istodobno primjenjuje sa sublingualnim, oralnim ili transdermalnim nitratima.
English: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Croatian: Neiskorišteni lijek ili otpadni materijal valja zbrinuti sukladno nacionalnim propisima.
English: Neparvis can be administered with or without food.
Croatian: Neparvis se može primjenjivati uz hranu ili bez nje.
English: If angioedema occurs, Neparvis should be immediately discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred.
Croatian: Ako se pojavi angioedem, primjenu Neparvisa treba odmah prekinuti te pružiti odgovarajuću terapiju i praćenje dok se znakovi i simptomi u potpunosti i trajno ne povuku.
English: Pharmacotherapeutic group: Agents acting on the renin-angiotensin system; angiotensin II antagonists, other combinations, ATC code: C09DX04
Croatian: Farmakoterapijska skupina: tvari koje djeluju na renin-angiotenzinski sustav; antagonisti angiotenzina II, druge kombinacije, ATK oznaka: C09DX04
English: If you forget to take Neparvis
Croatian: Ako ste zaboravili uzeti Neparvis
English: • if you are suffering from dehydration.
Croatian: • ako ste dehidrirani.
English: The components of Neparvis, sacubitril and valsartan, were excreted in the milk of lactating rats (see section 5.3).
Croatian: Sastojci Neparvisa, sakubitril i valsartan, izlučivali su se u mlijeko štakora u laktaciji (vidjeti dio 5.3).
English: There was no drug-drug interaction between Neparvis and intravenously administered nitroglycerin with regard to blood pressure reduction.
Croatian: Nije bilo interakcije između Neparvisa i intravenski primijenjenog nitroglicerina s obzirom na smanjenje krvnog tlaka.
English: Within each frequency grouping, adverse reactions are ranked in order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti, nuspojave su navedene redom od najozbiljnijih prema manje ozbiljnima.
English: • some types of antibiotics (rifamycin group), ciclosporin (used to prevent rejection of transplanted organs) or antivirals such as ritonavir (used to treat HIV/AIDS).
Croatian: • neke vrste antibiotika (skupina rifamicina), ciklosporin (koristi se za sprječavanje odbacivanja presađenih organa) ili antivirusnih lijekova poput ritonavira (koristi se za liječenje
English: There is limited clinical experience in patients with moderate hepatic impairment (Child-Pugh B classification) or with AST/ALT values more than twice the upper limit of the normal range.
Croatian: Postoji ograničeno kliničko iskustvo u bolesnika s umjerenim oštećenjem jetre (Child-Pugh stupanj B) ili s AST/ALT vrijednostima višim od dvostruke vrijednosti gornje granice normalnog raspona.
English: • dizziness when switching from sitting to standing position
Croatian: • omaglica kod promjene položaja iz sjedećeg u stajaći
English: Patients with SBP <100 mmHg were not studied (see section 5.1).
Croatian: Bolesnici sa SKT <100 mmHg nisu bili ispitivani (vidjeti dio 5.1).
English: Where there is involvement of the tongue, glottis or larynx likely to cause airway obstruction, appropriate therapy, e.g. adrenaline solution 1 mg/1 ml (0.3-0.5 ml), and/or measures necessary to ensure a patent airway, should be promptly administered.
Croatian: Ako je uključen jezik, glotis ili larinks, što može uzrokovati opstrukciju dišnih puteva, potrebno je odmah primijeniti odgovarajuću terapiju, npr. otopinu adrenalina 1 mg/1 ml (0,3-0,5 ml) i/ili mjere potrebne da bi se osigurao otvoreni dišni put.
English: Sacubitril
Croatian: Sakubitril
English: Caution is required in patients with renal artery stenosis and monitoring of renal function is recommended.
Croatian: Potreban je oprez u bolesnika sa stenozom bubrežne arterije i preporučuje se praćenje bubrežne funkcije.
English: Talk to your doctor, pharmacist or nurse before taking Neparvis
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete Neparvis
English: Sacubitril is further metabolised to the active metabolite LBQ657.
Croatian: Sakubitril se dalje metabolizira u aktivni metabolit LBQ657.
English: A slight generalised delay in ossification was observed at doses of >50 mg/kg/day.
Croatian: Blago generalizirana odgoda osifikacije bila je uočena u dozama >50 mg/kg/dan.
English: LBQ657 and valsartan exposure are increased in subjects over 65 years of age by 42% and 30%, respectively, compared to younger subjects.
Croatian: Izloženost LBQ657 i valsartanu povećava se u ispitanika starijih od 65 godina za 42%, odnosno 30% u usporedbi s mlađim ispitanicima.
English: There is no experience in patients with end-stage renal disease and use of Neparvis is not recommended.
Croatian: Ne postoji iskustvo u bolesnika sa završnim stadijem bolesti bubrega te se primjena Neparvisa ne preporučuje.
English: Down-titration should be considered in patients who develop a clinically significant decrease in renal function.
Croatian: Postupno sniženje doze treba razmotriti u bolesnika u kojih se razvije klinički značajno smanjenje bubrežne funkcije.
English: The most common symptoms of heart failure are breathlessness, fatigue, tiredness and ankle swelling.
Croatian: Najčešći simptomi zatajenja srca su nedostatak zraka, umor, zamor i oticanje gležnjeva.
English: Neparvis may increase blood urea and serum creatinine levels in patients with bilateral or unilateral renal artery stenosis.
Croatian: Neparvis može povećati razine ureje u krvi i kreatinina u serumu u bolesnika s obostranom ili jednostranom stenozom bubrežne arterije.
English: Should exposure to ARBs have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Croatian: Ako je do izloženosti ARB-ovima došlo od drugog tromjesečja trudnoće nadalje, preporučuje se ultrazvučni pregled funkcije bubrega i lubanje.
English: • if you are taking another type of medicine called an angiotensin converting enzyme (ACE) inhibitor (for example enalapril, lisinopril or ramipril).
Croatian: • ako uzimate drugu vrstu lijeka koji se zove inhibitor angiotenzin konvertirajućeg enzima (ACE) (primjerice enalapril, lizinopril ili ramipril).
English: Increases in CSF Aβ1-40 and 1-42 were not observed in a two-week healthy volunteer study in humans (see section 5.1).
Croatian: Povećanja Aβ1-40 i 1-42 u cerebrospinalnoj tekućini nisu bila uočena u dvotjednom ispitivanju na zdravim dobrovoljcima (vidjeti dio 5.1).
English: Sacubitril, LBQ657 and valsartan are eliminated from plasma with a mean elimination half-life (T½) of approximately 1.43 hours, 11.48 hours, and 9.90 hours, respectively.
Croatian: Sakubitril, LBQ657 i valsartan eliminiraju se iz plazme sa srednjim vremenom polueliminacije (T½) od otprilike 1,43 sata, 11,48 sati, odnosno 9,90 sati.
English: Following oral administration, 52-68% of sacubitril (primarily as LBQ657) and ~13% of valsartan and its metabolites are excreted in urine; 37-48% of sacubitril (primarily as LBQ657) and 86% of valsartan and its metabolites are excreted in faeces.
Croatian: Nakon peroralne primjene, 52-68% sakubitrila (prvenstveno kao LBQ657) i ~13% valsartana i njegovih metabolita izlučuje se mokraćom; 37-48% sakubitrila (prvenstveno kao LBQ657) i 86% valsartana i njegovih metabolita izlučuje se stolicom.
English: The usual recommended target dose is 97 mg/103 mg twice a day (one tablet in the morning and one tablet in the evening).
Croatian: Uobičajena preporučena ciljna doza je 97 mg/103 mg dvaput na dan (jedna tableta ujutro i jedna tableta uvečer).
English: Approximate tablet dimensions 15.1 mm x 6.0 mm.
Croatian: Približne dimenzije tablete 15,1 mm x 6,0 mm.
English: • nitroglycerine, a medicine used to treat angina.
Croatian: • nitroglicerin, lijek koji se koristi za liječenje angine.
English: In juvenile rats treated with sacubitril (postnatal days 7 to 70), there was a reduction in age-related bone mass development and bone elongation.
Croatian: U juvenilnih štakora liječenih sakubitrilom (postnatalni dani od 7. do 70.), došlo je do smanjenja razvoja koštane mase i produljenja kosti povezanih s dobi.
English: No impairment of fertility was demonstrated in studies with it in male and female rats (see section 5.3).
Croatian: Nije dokazano narušavanje plodnosti u ispitivanjima s njim u mužjaka i ženki štakora (vidjeti dio 5.3).
English: Sacubitril, LBQ657 and valsartan are highly bound to plasma proteins (94-97%).
Croatian: Sakubitril, LBQ657 i valsartan se u velikoj mjeri vežu za proteine u plazmi (94-97%).