FrancophonIA/ELRC3.0 huggingface dataset:
English: You or your child should take this medicine on an empty stomach.
Croatian: Vi ili Vaše dijete trebate ovaj lijek uzimati natašte.
English: The most frequent ADRs observed at an incidence ≥1.0% were: Headache (3.9%), Electrocardiogram QTc Prolonged (3.4%), P. falciparum infection (3.0%), Anaemia (2.8%), Eosinophilia (1.7%), Haemoglobin decreased (1.7%), Sinus tachycardia (1.7%), Asthenia (1.6%), Haematocrit [decreased] (1.6%), Pyrexia (1.5%), Red Blood Cell Count decreased (1.4%).
Croatian: Najčešće opažene nuspojave s incidencijom od ≥1,0% bile su: glavobolja (3,9%), produljeni QTc na elektrokardiogramu (3,4%), infekcija P. falciparum (3,0%), anemija (2,8%), eozinofilija (1,7%), sniženi hemoglobin (1,7%), sinusna tahikardija (1,7%), astenija (1,6%), hematokrit [sniženi] (1,6%), pireksija (1,5%), smanjeni broj crvenih krvnih stanica (1,4%).
English: Literature data concerning chronic toxicity of piperaquine in dogs and monkeys indicate some hepatotoxicity and mild reversible depression of total white cell and neutrophil counts.
Croatian: Podaci u literaturi koji se odnose na kroničnu toksičnost piperakina u pasa i majmuna ukazuju na određenu hepatotoksičnost i blago reverzibilno smanjenje ukupnog broja bijelih krvnih stanica i neutrofila.
English: Based on animal data Eurartesim is suspected to harm the unborn child when used during the first three months of pregnancy.
Croatian: Na temelju ispitivanja u životinja, sumnja se da bi primjena Eurartesima tijekom prva tri mjeseca trudnoće mogla naškoditi nerođenom djetetu.
English: 1.5 tablet
Croatian: 1,5 tableta
English: 24 to <36
Croatian: 24 do <36
English: White oblong biconvex film-coated tablet (dimension 11.5x5.5mm / thickness 4.4mm) with a break-line and marked on one side with the letters “S” and “T”.
Croatian: Bijela, duguljasta, bikonveksna filmom obložena tableta (dimenzija 11,5 x 5,5 mm / debljine 4,4 mm) s razdjelnom crtom i označena s jedne strane slovima “S” i “T”.
English: The mean oral clearance for adult patients with malaria was 2.09 l/h/kg, while in paediatric patients was 2.43 l/h/kg.
Croatian: Prosječni oralni klirens u odraslih bolesnika s malarijom bio je 2,09 l/h/kg, dok je u pedijatrijskih bolesnika iznosio 2,43 l/h/kg.
English: A corresponding table for paediatric patients is presented in the specific section below.
Croatian: Odgovarajuća tablica za pedijatrijske bolesnike prikazana je niže u posebnom dijelu.
English: In the hERG test, the IC50 was 0.15 µmol for piperaquine and 7.7 µmol forartenimol.
Croatian: Na hERG testu, IC50 piperakina iznosio je 0,15 µmol, a artenimola 7,7 µmol.
English: Animal studies showed that radiolabelled piperaquine is excreted by the biliary route, while urinary excretion is negligible.
Croatian: Ispitivanja na životinjama pokazala su da se izotopom označeni piperakin izlučuje putem žuči, dok je izlučivanje urinom zanemarivo.
English: No healthy subject dosed in fasting conditions showed a QTcF greater than 480 msec or an increase over baseline greater than 60 msec.
Croatian: Ni u jednog zdravog ispitanika koji je primio dozu natašte nije se pokazao QTcF dulji od 480 ms ili povećanje u odnosu na početnu vrijednost veće od 60 ms.
English: There is potential for neurotoxicity of artemisinin derivatives in man and animals, which is strongly related to the dose, route and formulations of the different artenimol pro-drugs.
Croatian: Derivati artemizinina u čovjeka i životinja mogu biti neurotoksični, što je jako povezano s dozom, putem primjene i formulacijama različitih predlijekova artenimola.
English: Eurartesim has not been evaluated in patients with moderate or severe renal or hepatic insufficiency (see section 4.2).
Croatian: Eurartesim nije procijenjen u bolesnika s umjerenom do teškom insuficijencijom bubrega ili jetre (vidjeti dio 4.2).
English: − Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: Ažurirani RMP treba dostaviti: - na zahtjev Europske agencije za lijekove; - prilikom svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: Contact your doctor immediately if you or your child develops one or more of the following symptoms after treatment with Eurartesim: pale skin, general weakness, headache, shortness of breath and rapid heartbeat; particularly with exercise, confusion, dizziness, or dark-coloured urine.
Croatian: Odmah se obratite liječniku ako nakon liječenja Eurartesimom Vi ili Vaše dijete razvijete jedan ili više od sljedećih simptoma: bljedilo kože, opća slabost, glavobolja, nedostatak zraka i ubrzani otkucaji srca - osobito prilikom tjelesne aktivnosti, smetenost, omaglica ili tamna boja mokraće.
English: You can drive or use machines after taking Eurartesim once you have recovered from your illness.
Croatian: Nakon uzimanja Eurartesima možete upravljati vozilima i rukovati strojevima čim se oporavite od bolesti.
English: - Recent treatment with medicinal products known to prolong the QTc interval that may still be circulating at the time that Eurartesim is commenced (e.g. mefloquine, halofantrine, lumefantrine, chloroquine, quinine and other antimalarial medicinal products) taking into account their elimination half-life.
Croatian: Nedavno liječenje lijekovima za koje se zna da produljuju QTc interval i koji još uvijek mogu biti prisutni u krvotoku u vrijeme kad se započne s Eurartesimom (npr. meflokin, halofantrin, lumefantrin, klorokin, kinin i drugi antimalarici) s obzirom na njihov poluvijek eliminacije.
English: Artenimol causes embryolethality and teratogenicity in rats and rabbits.
Croatian: Artenimol je embriocidan i teratogen u štakora i kunića.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu
English: However, it is reported in the literature that the excretion of unchanged active substance in human urine and faeces is negligible for artemisinin derivatives.
Croatian: Međutim, u literaturi je zabilježeno da je za derivate artemizinina izlučivanje neizmijenjene djelatne tvari u ljudskom urinu i fecesu zanemarivo.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V
Croatian: Od zdravstvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava: navedenog u
English: Studies in human liver microsomes showed that artenimol was metabolised by the UDP-glucuronosyltransferase (UGT1A9 and UGT2B7) to α-artenimol-G with no cytochrome P450-mediated metabolism.
Croatian: Ispitivanja na mikrosomima ljudske jetre pokazala su da se artenimol metabolizira pomoću UDP-glukuronoziltransferaze (UGT1A9 i UGT2B7) u α-artenimol-G bez metabolizma posredovanog citokromom P450.
English: Infections and infestations
Croatian: Infekcije i infestacije infekcija
English: • That Eurartesim is contraindicated in patients with severe malaria according to WHO definition and in patients with a history of clinical conditions that may lead to QTc interval prolongation, and in patients taking drugs that are known to prolong the QTc interval.
Croatian: • Da je Eurartesim kontraindiciran u bolesnika s teškom malarijom prema definiciji SZO-a i u bolesnika koji u anamnezi imaju klinička stanja koja mogu dovesti do produljenja QTc intervala te u bolesnika koji uzimaju lijekove za koje se zna da produljuju QTc interval.
English: Pharmacotherapeutic group: Antiprotozoals, antimalarials, artemisinin and derivatives, combinations, ATC code: P01BF05
Croatian: Farmakoterapijska skupina: antiprotozoici, antimalarici, artemizinin i derivati, kombinacije, ATK oznaka: P01BF05
English: The most important potential cardiac effect was related to cardiac conduction.
Croatian: Najvažniji mogući učinak na srce odnosi se na provođenje impulsa kroz srce.
English: In clinical trials with Eurartesim limited ECGs were obtained during treatment.
Croatian: U kliničkim ispitivanjima Eurartesima učinjeni su EKG-i tijekom liječenja.
English: In vitro drug-drug interaction studies revealed that artenimol is an inhibitor of CYP1A2; therefore, there is the potential for artenimol to increase plasma concentrations of CYP1A2 substrates (see section 4.5).
Croatian: Ispitivanja interakcija lijekova in vitro pokazala su da je artenimol inhibitor CYP1A2; stoga postoji mogućnost da artenimol poveća koncentracije u plazmi CYP1A2 supstrata (vidjeti dio 4.5).
English: • Inhibition of falciparum sarcoplasmic-endoplasmic reticulum calcium ATPase,
Croatian: • inhibiciju kalcij APT-aze sarkoplazmatsko-endoplazmatskog retikuluma P. falciparum
English: The long half-life of piperaquine (about 22 days) should be kept in mind in the event that another antimalarial agent is started due to treatment failure or a new malaria infection (see below and sections 4.3 and 4.5).
Croatian: Potrebno je imati na umu dugi poluvijek piperakina (oko 22 dana) u slučaju da se, zbog neuspješnog liječenja ili nove malarične infekcije, započne drugi antimalarik (vidjeti u nastavku, kao i dijelove 4.3 i 4.5).
English: Eurartesim should not be used during the 1st trimester of pregnancy in situations where other suitable and effective antimalarials are available (see section 4.6).
Croatian: Eurartesim se ne smije primjenjivati tijekom prvoga tromjesečja trudnoće u situacijama kad su dostupni drugi pogodni i učinkoviti antimalarici (vidjeti dio 4.6).
English: Eurartesim is contraindicated in patients already taking other medicinal products that are known to prolong the QTc interval due to the risk of a pharmacodynamic interaction leading to an additive effect on the QTc interval (see sections 4.3 and 4.4).
Croatian: Eurartesim je kontraindiciran u bolesnika koji već uzimaju druge lijekove za koje se zna da produljuju QTc interval zbog rizika od farmakodinamičke interakcije koja dovodi do aditivnog učinka na QTc interval (vidjeti dijelove 4.3 i 4.4).
English: 7 to <13
Croatian: 7 do <13
English: 13 to <24
Croatian: 13 do <24
English: An ECG should be obtained as early as possible during treatment with Eurartesim and ECG monitoring should be applied in patients who may have a higher risk of developing arrhythmia in association with QTc prolongation (see below).
Croatian: EKG je potrebno napraviti što ranije tijekom liječenja Eurartesimom, a praćenje EKG-om potrebno je provoditi u svih bolesnika koji mogu imati povišen rizik od razvoja aritmije povezane s produljenjem QTc intervala (vidjeti u nastavku).
English: PCR-corrected cure rate (m-ITT) Eurartesim AS + MQ A + L
Croatian: Eurartesim AS + MQ A + L
English: Piperaquine pharmacokinetic parameters were found to be similar in healthy volunteers of Asian and Caucasian origin.
Croatian: Otkriveno je da su farmakokinetički parametri piperakina slični u zdravih dobrovoljaca azijskog i bjelačkog porijekla.
English: In human studies, piperaquine was found to be a mild inhibitor of CYP3A4 enzyme while potent inhibitors of CYP3A4 activity caused mild inhibition of piperaquine metabolism (see section 4.5).
Croatian: U ispitivanjima na ljudima, ustanovljeno je da je piperakin blagi inhibitor enzima CYP3A4, a jaki inhibitori aktivnosti CYP3A4 prouzročili su blagu inhibiciju metabolizma piperakina (vidjeti dio 4.5).
English: Due to the lack of multiple dose PK data for piperaquine, administration of any strong CYP3A4-inhibitors should be discouraged after initiation (i.e. the first dose) of Eurartesim (see sections 4.5 and 5.2).
Croatian: Zbog nedostatka farmakokinetičkih podataka o primjeni višestrukih doza piperakina, ne savjetuje se primjena bilo kojeg jakog inhibitora CYP3A4 nakon uvođenja (tj. prve doze) Eurartesima (vidjeti dijelove 4.5 i 5.2).
English: If you are not sure about any of the above, please ask your doctor or pharmacist.
Croatian: Ako niste sigurni u nešto od gore navedenog, obratite se svom liječniku ili ljekarniku.
English: Skin and subcutaneous Tissue disorders
Croatian: Poremećaji kože i potkožnog tkiva pruritis
English: These showed that QTc prolongation occurred more frequently and to a larger extent in association with Eurartesim therapy than with the comparators (see section 5.1 for details of the comparators).
Croatian: Pokazano je da se produljenje QTc intervala javljalo češće i u većoj mjeri s terapijom Eurartesimom nego s usporednom terapijom (vidjeti dio 5.1 za podatke o usporednoj terapiji).
English: Artenimol pharmacokinetic parameters were found to be similar in healthy volunteers of Asian and Caucasian origin.
Croatian: Otkriveno je da su farmakokinetički parametri artenimola slični u zdravih dobrovoljaca azijskog i bjelačkog porijekla.
English: The 160 mg/20 mg tablets have the letters ‘S' and ‘T' on one side and come in blisters containing 3 tablets.
Croatian: Tablete od 160 mg/20 mg imaju slova ‘S' i ‘T' na jednoj strani i isporučuju se u blisterima koji sadrže
English: Magyarország, Malta, Norge, Österreich, Polska, România, Slovenija, Slovenská republika,
Croatian: България, Česká republika, Danmark, Eesti, Hrvatska, Ireland, Ísland, Latvija, Lietuva, Magyarország, Malta, Norge, Österreich, Polska, România, Slovenija, Slovenská republika, Suomi/Finland, Sverige, UK
English: If you or your child stops taking Eurartesim
Croatian: Vi ili Vaše dijete počnete uzimati Eurartesim
English: Moreover, from in vitro and in vivo data in animals, piperaquine and artenimol tend to accumulate in RBC.
Croatian: Nadalje, podaci prikupljeni in vitro i in vivo na životinjama pokazuju da se piperakin i artenimol nakupljaju u eritrocitima.
English: From in vitro data, piperaquine undergoes a low level of metabolism by CYP2C19, and is also an inhibitor of this enzyme.
Croatian: Prema podacima dobivenim in vitro, piperakin se u maloj mjeri metabolizira putem CYP2C19 i također inhibira taj enzim.
English: Piperaquine is a mild inhibitor of CYP3A4.
Croatian: Piperakin je blagi inhibitor CYP3A4.
English: Patients and caregivers should be advised to be vigilant for signs and symptoms of post-treatment haemolysis such as pallor, jaundice, dark-coloured urine, fever, fatigue, shortness of breath, dizziness and confusion.
Croatian: Bolesnicima i njihovim njegovateljima treba savjetovati da pozorno paze na moguću pojavu znakova i simptoma hemolize koja se može razviti poslije terapije, kao što su bljedilo, žutica, tamna boja urina, vrućica, umor, nedostatak zraka, omaglica i konfuzija.
English: A moderate increase of piperaquine plasma concentrations (<2-fold) was observed when co-administered with strong CYP3A4 inhibitors, resulting in a potential exacerbation of the effect on QTc prolongation (see section 4.5).
Croatian: Umjereno povećanje koncentracija piperakina u plazmi (<2 puta) opaženo je kada se primjenjivao istovremeno s jakim inhibitorima CYP3A4, što je rezultiralo mogućim pogoršanjem učinka na produljenje QTc intervala (vidjeti dio 4.5).
English: България, Česká republika, Danmark, Eesti, Hrvatska, Ireland, Ísland, Latvija, Lietuva,
Croatian: България, Česká republika, Danmark, Eesti, Hrvatska, Ireland, Ísland, Latvija, Lietuva, Magyarország, Malta, Norge, Österreich, Polska, România, Slovenija, Slovenská republika, Suomi/Finland, Sverige, UK.
English: These may increase the QTc-prolonging effect of Eurartesim (see section 4.3).
Croatian: To može pojačati učinak Eurartesima na produljenje QTc intervala (vidjeti dio 4.3).
English: Effects on blood pressure and on PR and QRS duration were observed at high piperaquine doses.
Croatian: Kod visokih doza piperakina opaženi su učinci na krvni tlak i trajanje PR i QRS.
English: Malaria is caused by infection with a parasite called Plasmodium, spread by the bite of an infected mosquito.There are different types of Plasmodium parasite.
Croatian: Malariju uzrokuje infekcija parazitom koji se zove Plasmodium, a prenosi se ubodom zaraženog komarca.
English: Piperaquine was found to be an inhibitor of CYP3A4 (also in a time-dependent way) and to a lesser extent of CYP2C19, while it stimulated the activity of CYP2E1.
Croatian: Otkriveno je da piperakin inhibira CYP3A4 (također na način ovisan o vremenu) i u manjem opsegu CYP2C19, dok stimulira aktivnost CYP2E1.
English: Therefore Eurartesim should not be used during the 1st trimester of pregnancy in situations where other suitable and effective anti-malarials are available (see section 4.4).
Croatian: Stoga se Eurartesim ne smije primjenjivati tijekom prvog tromjesječja trudnoće u situacijama kad su dostupni drugi pogodni i učinkoviti antimalarici (vidjeti dio 4.4).
English: Eurartesim has not been evaluated in subjects with moderate or severe renal or hepatic insufficiency.
Croatian: Eurartesim nije procijenjen u ispitanika s umjerenom ili teškom insuficijencijom bubrega ili jetre.
English: In cases of suspected overdose, symptomatic and supportive therapy should be given as appropriate, including ECG monitoring because of the possibility of QTc interval prolongation (see section 4.4).
Croatian: U slučajevima sumnje na predoziranje, potrebno je primijeniti odgovarajuću simptomatsku i potpornu terapiju, uključujući EKG nadzor zbog mogućnosti produljenja QTc intervala (vidjeti dio 4.4).
English: • Disruption of parasite mitochondrial function
Croatian: • poremećaj mitohondrijske funkcije parazita.
English: • Interference with mitochondrial electron transport
Croatian: • ometanje prijenosa elektrona u mitohondrijima
English: The concurrent administration of oral Eurartesim with 7.5 mg oral midazolam, a CYP3A4 probe substrate, led to a modest increase (≤2-fold) in midazolam and its metabolites exposures in healthy adult subjects.
Croatian: Istovremena primjena oralnog Eurartesima sa 7,5 mg oralnog midazolama, probnog supstrata CYP3A4, dovela je u zdravih odraslih ispitanika do malog povećanja izloženosti (≤2 puta) midazolamu i njegovim metabolitima.
English: White oblong biconvex film-coated tablet (dimension 16x8mm / thickness 5.5mm) with a break-line and marked on one side with two “σ” letters.
Croatian: Bijela, duguljasta, bikonveksna filmom obložena tableta (dimenzija 16 x 8 mm / debljine 5,5 mm) s razdjelnom crtom i označena s jedne strane s dva slova “σ”.
English: Sometimes a problem with your red blood cells, called haemolytic anaemia can occur after receiving malaria treatment.
Croatian: Katkad se poslije terapije protiv malarije može pojaviti poremećaj povezan s crvenim krvnim stanicama pod nazivom hemolitička anemija.
English: Pharmacokinetics in special patient populations No specific pharmacokinetic studies have been performed in patients with hepatic or renal insufficiency, or in elderly people.
Croatian: Nisu provedena posebna farmakokinetička ispitivanja u bolesnika s insuficijencijom jetre ili bubrega ili u starijih osoba.
English: No more than two courses of Eurartesim may be given within a 12 month period (see sections 4.4 and
Croatian: U razdoblju od 12 mjeseci ne smije se dati više od dvije kure Eurartesima (vidjeti dijelove 4.4 i 5.3).
English: Frequency of ADRs in adult patients participating in clinical studies with Eurartesim:
Croatian: Učestalost nuspojava u odraslih bolesnika koji su sudjelovali u kliničkim ispitivanjima Eurartesima:
English: diazepam, alprazolam), zaleplon, zolpidem; - medicines used to prevent/treat epileptic seizures: barbiturates (such as phenobarbital),
Croatian: alprazolam), zaleplon, zolpidem; - lijekovi za sprječavanje/liječenje epileptičkih napadaja: barbiturati (kao što je fenobarbital),
English: Piperaquine was not teratogenic in the rat or rabbit.
Croatian: Piperakin nije bio teratogen u štakora i kunića.
English: • Inhibition of haem-digestion pathway in the parasite food vacuole.
Croatian: • inhibicija puta probave hema u prehrambenoj vakuoli parazita.
English: simvastatin); - medicines used to treat hypertension and heart problems (such as diltiazem, nifedipine,
Croatian: simvastatin); - lijekovi za liječenje hipertenzije i srčanih tegoba (kao što su diltiazem, nifedipin, nitrendipin,
English: Piperaquine is also a substrate of CYP3A4.
Croatian: Piperakin je također supstrat za CYP3A4.
English: Frequency of ADRs in paediatric patients participating in clinical studies with Eurartesim:
Croatian: Učestalost nuspojava u pedijatrijskih bolesnika koji su sudjelovali u kliničkim ispitivanjima Eurartesima:
English: Anaemia, headache, heart rhythm disturbances (ECG changes or noticing unusually fast heart beats or palpitations), fever, general weakness.
Croatian: Anemija, glavobolja, poremećaj srčanog ritma (promjene na EKG-u ili zamjećivanje neobično ubrzanog rada srca ili osjećaj lupanja srca), vrućica, opća slabost.
English: Email: antonietta.pazardjiklian@alfasigma.com
Croatian: E-mail: antonietta.pazardjiklian@alfasigma.com
English: • Certain non-sedating antihistamines (e.g. terfenadine, astemizole, mizolastine).
Croatian: • određeni antihistaminici bez sedativnog djelovanja (npr. terfenadin, astemizol, mizolastin)
English: • Cisapride, droperidol, domperidone, bepridil, diphemanil, probucol, levomethadyl, methadone, vinca alkaloids, arsenic trioxide.
Croatian: • cisaprid, droperidol, domperidon, bepridil, difemanil, probukol, levometadil, metadon, vinka alkaloidi, arsenov trioksid.
English: • Neuroleptics (e.g. phenothiazines, sertindole, sultopride, chlorpromazine, haloperidol, mesoridazine, pimozide, or thioridazine), antidepressive medicinal products.
Croatian: • neuroleptici (npr. fenotiazini, sertindol, sultoprid, klorpromazin, haloperidol, mesoridazin, pimozid ili tioridazin), antidepresivi
English: For the medicine to work effectively, you or your child should take the tablets as instructed and should complete the 3 days course of treatment.
Croatian: Ako Vi ili Vaše dijete prestanete uzimati Eurartesim Da bi lijek bio učinkovit, Vi ili Vaše dijete trebate uzimati tablete prema uputama i trebate završiti trodnevnu kuru liječenja.
English: Effect of co-administered medicinal products on Eurartesim Piperaquine is metabolised by CYP3A4 in vitro.
Croatian: Učinak istovremeno primijenjenih lijekova na Eurartesim CYP3A4 metabolizira piperakin in vitro.
English: Film coating: hypromellose, titanium dioxide (E171), macrogol 400.
Croatian: Film-ovojnica: hipromeloza, titanijev dioksid (E171), makrogol 400.
English: If you or your child takes more than the recommended dose, tell your doctor.
Croatian: Ako Vi ili Vaše dijete uzmete više Eurartesim tableta nego što ste trebali Ako Vi ili Vaše dijete uzmete više od preporučene doze, obavijestite svog liječnika.
English: progesterone, estradiol), testosterone; - glucocorticoids (hydrocortisone, dexamethasone);
Croatian: progesteron, estradiol), testosteron; - glukokortikoidi (hidrokortizon, deksametazon); - omeprazol (primjenjuje se za liječenje bolesti povezanih sa stvaranjem želučane kiseline);
English: • The scope and use of the Contraindicated Conditions of Use and Contraindicated Concomitant Medication checklist
Croatian: • Stanja kontraindicirane primjene i popis lijekova čija je istovremena primjena kontraindicirana
English: Consequently, if Eurartesim is more suitable for a pregnant woman than other artemisinin-based combination therapies with a higher range of experience (or sulfadoxine-pyrimethamine), Eurartesim may be used in the 2nd and 3 trimester.
Croatian: Posljedično tomu, ako je Eurartesim za pojedinu trudnicu prikladniji nego druge kombinirane terapije na bazi artemizinina za koje postoji više iskustva (ili sulfadoksin-pirimetamin), Eurartesim se može primjenjivati u drugom i trećem tromjesečju trudnoće.