FrancophonIA/ELRC3.0 huggingface dataset:
English: If you think you were infected with HIV, tell your doctor straight away.
Slovenian: - Če menite, da ste okuženi s HIV, o tem nemudoma obvestite zdravnika.
English: Bone toxicity was diagnosed as osteomalacia (monkeys) and reduced BMD (rats and dogs).
Slovenian: Toksičen vpliv na kosti je bil diagnosticiran kot osteomalacija (pri opicah) in kot zmanjšan BMD (podgane in psi).
English: Keep the bottle tightly closed in order to protect from moisture and light.
Slovenian: Plastenko shranjujte tesno zaprto za zagotovitev zaščite pred svetlobo in vlago.
English: Although there are limited clinical data on the use of emtricitabine/tenofovir disoproxil in pregnant women, it is not usually used unless absolutely necessary.
Slovenian: - Čeprav je na voljo nekaj kliničnih podatkov o uporabi emtricitabina/dizoproksiltenofovirata pri nosečnicah, se ga ponavadi ne uporablja, razen če je nujno potrebno.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Zato bolniki z redko dedno intoleranco za galaktozo, odsotnostjo encima laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: - At the request of the European Medicines Agency; - Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: Posodobljen RMP je treba predložiti: - na zahtevo Evropske agencije za zdravila; - ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: osteomalacia (manifested as bone pain and infrequently contributing to fractures)
Slovenian: osteomalacija (ki se kaže kot bolečine v kosteh in redko prispeva k zlomom) miopatija
English: You must get tested to make sure that you do not already have HIV infection.
Slovenian: Testirajte se, da se prepričate, da še niste okuženi s HIV.
English: Look out for any symptoms of infection or other symptoms such as: - muscle weakness - weakness beginning in the hands and feet and moving up towards the trunk of the body - palpitations, tremor or hyperactivity
Slovenian: Bodite pozorni na kakršne koli simptome vnetja ali druge simptome, kot so: - mišična oslabelost - oslabelost, ki se najprej pojavi v dlaneh in stopalih in se nato širi proti trupu - palpitacije, tremor ali hiperaktivnost
English: Years living with study partner Years aware of discordant status
Slovenian: Zakonska zveza s partnerjem v študiji Število let življenja s partnerjem v študiji Število let zavedanja o neskladnosti
English: GS-01-934 Treatment for 144 weeks
Slovenian: GS-01-934 144-tedensko zdravljenje
English: Autoimmune disorders, when the immune system attacks healthy body tissue, may also occur after you start taking medicines to treat HIV infection.
Slovenian: - Avtoimunske bolezni, pri katerih imunski sistem napada zdravo telesno tkivo, se prav tako lahko pojavijo po začetku jemanja zdravil za okužbo s HIV.
English: - Always practice safer sex. Use condoms to reduce contact with semen, vaginal fluids, or blood.
Slovenian: Uporabljajte kondome, da zmanjšate stik s semensko tekočino, vaginalnimi izločki ali krvjo.
English: These infections make it easier for HIV to infect you.
Slovenian: Zaradi teh okužb se lahko lažje okužite s HIV.
English: renal failure (acute and chronic), acute tubular necrosis, nephritis (including acute interstitial nephritis)
Slovenian: ledvična odpoved (akutna in kronična), akutna tubularna nekroza, nefritis (vključno z akutnim intersticijskim nefritisom)
English: Limited data from clinical studies support once daily dosing in HIV-1 uninfected individuals with CrCl 60-80 mL/min.
Slovenian: Omejeno število podatkov iz kliničnih študij podpira odmerjanje enkrat dnevno pri posameznikih, ki niso okuženi s HIV-1, s CrCl 60 -80 ml/min.
English: Excipient(s) with known effect Each film-coated tablet contains 80 mg lactose monohydrate.
Slovenian: Pomožna snov z znanim učinkom: Ena filmsko obložena tableta vsebuje 80 mg laktoze monohidrata.
English: Seven patients had estimated glomerular filtration rate (GFR) values between 70 and 90 mL/min/1.73 m2.
Slovenian: Sedem bolnikov je imelo ocenjene vrednosti hitrosti glomerularne filtracije (GFR, glomerular filtration rate) med 70 in 90 ml/min/1,73 m2.
English: In general, emtricitabine pharmacokinetics in HBV infected subjects were similar to those in healthy subjects and in HIV infected patients.
Slovenian: Na splošno so bile farmakokinetične lastnosti emtricitabina pri osebah, okuženih z virusom HBV, zelo podobne tistim pri zdravih osebah in bolnikih, okuženih z virusom HIV.
English: Renal and bone effects in adults
Slovenian: Učinki na kosti in ledvice pri odraslih
English: The Marketing Authorisation Holder (MAH) shall ensure that all physicians who are expected to prescribe/use Emtricitabine/Tenofovir disoproxil Krka are provided with a physician educational pack containing the Summary of Product Characteristics and an appropriate educational brochure, as detailed below:
Slovenian: Imetnik dovoljenja za promet z zdravilom bo zagotovil, da bodo vsi zdravniki, pri katerih se pričakuje, da bodo predpisovali/uporabljali zdravilo Emtricitabin/dizoproksiltenofovirat Krka, dobili izobraževalni komplet za zdravnike, ki vsebuje Povzetek glavnih značilnosti zdravila in ustrezno izobraževalno gradivo, kot je navedeno spodaj:
English: Both of these active substances are antiretroviral medicines which are used to treat HIV infection.
Slovenian: Obe učinkovini sta protiretrovirusni zdravili, ki se uporabljata za zdravljenje okužbe z virusom HIV.
English: If you are a woman with HIV it is recommended that you do not breast-feed, to avoid passing the virus to the baby in breast milk.
Slovenian: - Če ste ženska, okužena z virusom HIV, je priporočljivo, da ne dojite, da s tem preprečite prenos virusa preko mleka na dojenčka.
English: Emtricitabine/Tenofovir disoproxil Krka should only be used for pre-exposure prophylaxis as part of an overall HIV-1 infection prevention strategy including the use of other HIV-1 prevention measures (e.g. consistent and correct condom use, knowledge of HIV-1 status, regular testing for other sexually transmitted infections).
Slovenian: Zdravilo Emtricitabin/dizoproksiltenofovirat Krka se sme uporabljati samo za zaščito pred izpostavitvijo kot del splošne strategije za preprečevanje okužbe s HIV-1, vključno z uporabo drugih ukrepov za preprečevanje HIV-1 (npr. dosledna in pravilna uporaba kondomov, zavedanje statusa okužbe s HIV-1, redno testiranje za druge spolno prenosljive okužbe).
English: However, tenofovir disoproxil reduced the viability index and weight of pups in a periand postnatal toxicity study at maternally toxic doses.
Slovenian: Vendar pa je dizoproksiltenofovirat zmanjšal indeks življenjskih funkcij in težo mladičkov v peri- in postnatalni študiji toksičnosti pri odmerkih, toksičnih za mater.
English: Therefore the use of Emtricitabine/Tenofovir disoproxil Krka may be considered during pregnancy, if necessary.
Slovenian: Zato se lahko pretehta možnost uporabe zdravila Emtricitabin/dizoproksiltenofovirat Krka med nosečnostjo, če je potrebno.
English: Emtricitabine/tenofovir disoproxil has not been studied in HIV-1 uninfected individuals with creatinine clearance < 60 mL/min and is therefore not recommended for use in this population.
Slovenian: Emtricitabin/dizoproksiltenofovirat ni bil preučevano pri posameznikih, ki niso okuženi s HIV-1, z očistkom kreatinina < 60 ml/min in se zato ne priporoča za uporabo pri tej populaciji.
English: Emtricitabine/tenofovir disoproxil is not always effective in preventing the acquisition of HIV-1.
Slovenian: Emtricitabin/dizoproksiltenofovirat ni vedno učinkovito pri preprečevanju okužbe s HIV-1.
English: The incidences of HIV seroconversion overall and in the subset reporting unprotected receptive anal intercourse are shown in Table 6.
Slovenian: Incidenci serokonverzije HIV na splošno in v podskupini (nezaščiten receptivni analni spolni odnos) sta prikazani v preglednici 6.
English: Reproductive toxicity studies in rats and rabbits showed no effects on mating, fertility, pregnancy or foetal parameters.
Slovenian: Študije o vplivu na sposobnost razmnoževanja na podganah in kuncih niso pokazale učinkov na parjenje, plodnost, nosečnost ali plod.
English: The frequency category was estimated from a statistical calculation based on the total number of patients exposed to emtricitabine in randomised controlled clinical studies (n = 1,563) or tenofovir disoproxil in randomised controlled clinical studies and the expanded access program (n = 7,319).
Slovenian: Kategorija pogostnosti je bila ocenjena s statističnim izračunom na podlagi skupnega števila bolnikov, izpostavljenih emtricatibinu v randomiziranih kontroliranih kliničnih študijah (n = 1 563) ali dizoproksiltenofoviratu v randomiziranih kontroliranih kliničnih študijah in podaljšanem programu dostopanja (n = 7 319).
English: If you have taken Emtricitabine/Tenofovir disoproxil Krka during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Slovenian: Če ste zdravilo Emtricitabin/dizoproksiltenofovirat Krka jemali med nosečnostjo, vas lahko zdravnik naroči na redne preiskave krvi in druge diagnostične preiskave, da bo spremljal razvoj vašega otroka.
English: These findings should be considered for any child exposed in utero to nucleos(t)ide analogues, who present with severe clinical findings of unknown etiology, particularly neurologic findings.
Slovenian: Te ugotovitve je treba upoštevati pri vseh otrokih, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom, pri katerih se pojavijo resne klinične ugotovitve neznanega vzroka, še zlasti nevrološke.
English: If you are taking another antiviral medicine called a protease inhibitor to treat HIV, your doctor may order blood tests to closely monitor your kidney function.
Slovenian: Če za zdravljenje HIV jemljete drugo protivirusno zdravilo, ki se imenuje zaviralec proteaze, bo zdravnik morda naročil krvne preiskave z namenom natančnega spremljanja delovanja vaših ledvic.
English: Relative risk reduction calculated for mITT cohort based on incident (post-baseline) seroconversion.
Slovenian: Relativno zmanjšanje tveganja, izračunano za mITT kohorto na podlagi dogodka serokonverzije (po izhodišču).
English: If you become pregnant, or plan to become pregnant, ask your doctor about the potential benefits and risks of therapy with Emtricitabine/Tenofovir disoproxil Krka to you and your child.
Slovenian: - Če zanosite ali načrtujete zanositev, se posvetujte z zdravnikom o možnih koristih in tveganjih zdravljenja z zdravilom Emtricitabin/dizoproksiltenofovirat Krka za vas in vašega otroka.
English: Emtricitabine/Tenofovir disoproxil Krka should only be used in individuals with creatinine clearance (CrCl) <80 mL/min if the potential benefits are considered to outweigh the potential risks.
Slovenian: Zdravilo Emtricitabin/dizoproksiltenofovirat Krka se sme uporabljati samo pri posameznikih z očistkom kreatinina (CrCl) < 80 ml/min, če se oceni, da morebitne koristi odtehtajo morebitna tveganja.
English: elevated serum aspartate aminotransferase (AST) and/or elevated serum alanine aminotransferase (ALT), hyperbilirubinaemia increased transaminases
Slovenian: zvišana serumska aspartat-aminotransferaza (AST) in/ali zvišana serumska alaninaminotransferaza (ALT), hiperbilirubinemija povišane transaminaze
English: Emtricitabine/Tenofovir disoproxil Krka contains lactose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Zdravilo Emtricitabin/dizoproksiltenofovirat Krka vsebuje laktozo Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred uporabo tega zdravila posvetujte s svojim zdravnikom.
English: If you are a woman who could get pregnant during treatment with Emtricitabine/Tenofovir disoproxil Krka, you must use an effective method of contraception to avoid becoming pregnant.
Slovenian: - Če ste ženska, ki bi lahko med zdravljenjem z zdravilom Emtricitabin/dizoproksiltenofovirat Krka zanosila, morate uporabljati učinkovito kontracepcijsko metodo, da bi s tem preprečili zanositev.
English: Relative risk reduction calculated for mITT based on incident seroconversion, ie, occurring post-baseline through first posttreatment visit (approximately 1 month after last study drug dispensation).
Slovenian: Relativno zmanjšanje tveganja, izračunano za mITT na podlagi dogodka serokonverzije, tj. pojav po izhodišču do prvega obiska po zdravljenju (približno 1 mesec po zadnjem odmerku preiskovanega zdravila).
English: Patients infected with HBV who discontinue Emtricitabine/Tenofovir disoproxil Krka should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment.
Slovenian: Bolniki z okužbo s HBV, ki prekinejo zdravljenje z zdravilom Emtricitabin/dizoproksiltenofovirat Krka, potrebujejo natančno spremljanje z ustreznimi kliničnimi in laboratorijskimi preiskavami še vsaj nekaj mesecev po prenehanju zdravljenja.
English: 28 film-coated tablets: EU/1/16/1151/001 84 film-coated tablets: EU/1/16/1151/003
Slovenian: 28 filmsko obloženih tablet: EU/1/16/1151/001 84 filmsko obloženih tablet EU/1/16/1151/003
English: Administration of emtricitabine/tenofovir disoproxil with food resulted in a delay of approximately three quarters of an hour in reaching maximum tenofovir concentrations and increases in tenofovir AUC and Cmax of approximately 35% and 15%, respectively, when administered with a high fat or light meal, compared to administration in the fasted state.
Slovenian: Jemanje emtricitabina/dizoproksiltenofovirata s hrano je povzročilo približno tričetrturno zakasnitev pri doseganju maksimalne koncentracije tenofovirja ter povečanju AUC tenofovirja za približno 35 % in Cmax za približno 15 % pri jemanju skupaj z obrokom, bogatim z maščobami ali lažjim obrokom, v primerjavi z jemanjem na tešče.
English: Following intravenous administration the volume of distribution of emtricitabine and tenofovir was approximately 1.4 L/kg and 800 mL/kg, respectively.
Slovenian: Po intravenskem odmerku je volumen porazdelitve emtricitabina znašal približno 1,4 l/kg in volumen porazdelitve tenofovirja približno 800 ml/kg.
English: Shelf life after first opening of the bottle: 1 month.
Slovenian: Rok uporabnosti po prvem odprtju plastenke: 1 mesec.
English: Talk to your doctor if you are intolerant to lactose (see Emtricitabine/Tenofovir disoproxil Krka contains lactose later in this section).
Slovenian: - Z zdravnikom se posvetujte, če imate intoleranco za laktozo (glejte Zdravilo Emtricitabin/dizoproksiltenofovirat Krka vsebuje laktozo v nadaljevanju tega poglavja).
English: If you have difficulty swallowing, you can use the tip of a spoon to crush the tablet.
Slovenian: Če imate težave s požiranjem, lahko tableto zdrobite s konico žlice.
English: Interactions between emtricitabine/tenofovir disoproxil or its individual component(s) and other medicinal products are listed in Table 2 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, twice daily as “b.i.d.” and once daily as “q.d.”).
Slovenian: Interakcije med emtricitabinom/dizoproksiltenofoviratom ali njegovo(-imi) posamično(-imi) učinkovino(-ami) in drugimi zdravili so navedene v preglednici 2 spodaj (povečanje je označeno z znakom "↑", zmanjšanje z "↓", brez spremembe z "↔", dvakrat na dan z "dvakrat dnevno" in enkrat na dan pa z "enkrat dnevno").
English: The effects of tenofovir disoproxilassociated changes in BMD on long-term bone health and future fracture risk are currently unknown (see section 5.1).
Slovenian: Učinki sprememb v MKG zaradi dizoproksiltenofovirata na dolgoročno zdravje kosti in tveganje za prihodnje zlome trenutno niso znani (glejte poglavje 5.1).
English: Use is not recommended in HIV-1 uninfected individuals with CrCl < 60 mL/min as it has not been studied in this population (see sections 4.4 and 5.2).
Slovenian: Uporaba se ne priporoča pri posameznikih, ki niso okuženi s HIV-1, s CrCl < 60 ml/min, ker pri tej populaciji študije niso bile opravljene (glejte poglavji 4.4 in 5.2).
English: Relative risk reduction calculated on incident (post-baseline) seroconversion from the double-blind treatment period and through the 8-week follow-up period.
Slovenian: Relativno zmanjšanje tveganja, izračunano na podlagi dogodka serokonverzije (po izhodišču) od dvojno slepega obdobja zdravljenja do 8-tedenskega obdobja spremljanja.
English: Store in the original blister in order to protect from moisture and light.
Slovenian: Shranjujte v originalnem pretisnem omotu za zagotovitev zaščite pred svetlobo in vlago.
English: Interrupting use of Emtricitabine/Tenofovir disoproxil Krka should also be considered in case of progressive decline of renal function when no other cause has been identified.
Slovenian: O prekinitvi uporabe zdravila Emtricitabin/dizoproksiltenofovirat Krka je treba razmisliti tudi v primeru progresivnega upada ledvične funkcije, če ni bil ugotovljen noben drug razlog.
English: When using emtricitabine/tenofovir for pre-exposure prophylaxis individuals should be reassessed at each visit to ascertain whether they remain at high risk of HIV-1 infection.
Slovenian: Pri uporabi zdravila emtricitabine/dizoproksiltenofovirat pri posameznikih za zaščito pred izpostavitvijo je treba ob vsakem obisku ponovno oceniti, ali so še vedno močno izpostavljeni tveganju za okužbo z virusom HIV-1.
English: Talk to your doctor if you are over 65.
Slovenian: - Če ste starejši od 65 let, se posvetujte z zdravnikom.
English: Also, emtricitabine did not inhibit uridine-5'-diphosphoglucuronyl transferase, the enzyme responsible for glucuronidation.
Slovenian: Emtricitabin tudi ni inhibiral uridin-5'difosfoglukuronil-transferaze, encima, ki je odgovoren za glukuronidacijo.
English: Steady-state pharmacokinetics of tenofovir were evaluated in 8 HIV-1 infected adolescent patients (aged 12 to < 18 years) with body weight ≥ 35 kg and in 23 HIV1 infected children aged 2 to < 12 years.
Slovenian: Farmakokinetične lastnosti tenofovirja v stanju dinamičnega ravnovesja so bile ocenjene pri 8 mladostnikih s HIV-1 (starih od 12 do < 18 let) s telesno maso ≥ 35 kg in pri 23 otrocih s HIV-1, starih od 2 do < 12 let.
English: At baseline the randomised groups had similar median plasma HIV-1 RNA (5.02 and 5.00 log10 copies/mL) and CD4 counts (233 and 241 cells/mm
Slovenian: Ob izhodišču so imele randomizirane skupine podobno mediano števila HIV-1 RNA v plazmi (5,02 in 5,00 log10 kopij/ml) in CD4 (233 in 241 celic/mm3).
English: The use of Emtricitabine/Tenofovir disoproxil Krka is not recommended in patients with severe renal impairment (creatinine clearance < 30 mL/min) and in patients who require haemodialysis since appropriate dose reductions cannot be achieved with the combination tablet (see sections 4.2 and 5.2).
Slovenian: Uporaba zdravila Emtricitabin/dizoproksiltenofovirat Krka se ne priporoča pri bolnikih s hudo ledvično okvaro (očistek kreatinina < 30 ml/min) in bolnikih, ki potrebujejo hemodializo, ker ustreznega zmanjšanja odmerka ni mogoče doseči s kombinirano tableto (glejte poglavji 4.2 in 5.2).
English: There have been reports of a high rate of virological failure and of emergence of resistance at an early stage in HIV-1 infected patients when tenofovir disoproxil was combined with lamivudine and abacavir as well as with lamivudine and didanosine as a once daily regimen.
Slovenian: Obstajajo poročila o visoki stopnji virološkega neuspeha in pojavu rezistence v zgodnji fazi, kadar se je dizoproksiltenofovirat kombiniral z lamivudinom in abakavirjem kakor tudi z lamivudinom in didanozinom kot režim zdravljenja enkrat na dan.
English: People who do have HIV must take Emtricitabine/Tenofovir disoproxil Krka in combination with other drugs.
Slovenian: Ljudje, ki imajo HIV, morajo zdravilo Emtricitabin/dizoproksiltenofovirat Krka jemati v kombinaciji z drugimi zdravili.
English: Tests may also show: decreases in phosphate in the blood increased creatine kinase
Slovenian: Preiskave lahko kažejo tudi: - zmanjšanje količine fosfata v krvi - povišanje kreatin-kinaze
English: ** The p-value based on the Cochran-Mantel-Haenszel Test stratified for baseline CD4 cell count TLOVR = Time to Loss of Virologic Response a: Van Elteren Test
Slovenian: ** Vrednost p temelji na Cochran-Mantel-Haenszlovem testu, stratificiranem za število celic CD4 ob izhodišču.
English: → If you notice any of the side effects listed above or if any of the side effects get serious, talk to your doctor or pharmacist.
Slovenian: → Če opazite katerega od zgoraj navedenih neželenih učinkov ali če kateri koli od neželenih učinkov postane resen, se posvetujte z zdravnikom ali farmacevtom.
English: BLISTER (OPA/Alu/PE+DES-Alu FOIL)
Slovenian: PRETISNI OMOT/(OPA/Al/PE+DES - Al folija)
English: Emtricitabine/Tenofovir disoproxil Krka is also used to reduce the risk of getting HIV-1 infection in adults, and adolescents aged 12 years to less than 18 years who weigh at least 35 kg, when taken daily, together with safer sex practices:
Slovenian: - Zdravilo Emtricitabin/dizoproksiltenofovirat Krka se uporablja tudi za zmanjšanje tveganja za okužbo z virusom HIV-1 pri odraslih in mladostnikih, starih od 12 do 18 let, ki tehtajo vsaj 35 kg, kadar se jemlje vsakodnevno, ob hkratnem upoštevanju varnega spolnega vedenja:
English: Severe renal impairment (CrCl < 30 mL/min) and haemodialysis patients
Slovenian: Huda ledvična okvara (CrCl < 30 ml/min) in bolniki na hemodializi
English: Individuals over the age of 65 years are more likely to have decreased renal function, therefore caution should be exercised when administering Emtricitabine/Tenofovir disoproxil Krka to older people.
Slovenian: Obstaja večja verjetnost, da je ledvična funkcija pri posameznikih, starejših od 65 let, zmanjšana, zato je pri dajanju zdravila Emtricitabin/dizoproksiltenofovirat Krka starejšim ljudem potrebna previdnost.
English: Pre-exposure prophylaxis in the paediatric population The efficacy and safety of emtricitabine/tenofovir disoproxil for pre-exposure prophylaxis in adolescents who adhere to daily dosing is expected to be similar to that in adults at the same level of adherence.
Slovenian: Zaščita pred izpostavitvijo pri pediatrični populaciji Pričakuje se, da sta učinkovitost in varnost emtricitabina/dizoproksiltenofovirata za zaščito pred izpostavitvijo pri mladoletnikih, ki upoštevajo dnevno odmerjanje, podobni kot pri odraslih z enako ravnjo adherence.
English: In addition, the clinical response to treatment should be closely monitored in patients receiving Emtricitabine/Tenofovir disoproxil Krka at a prolonged dosing interval.
Slovenian: Poleg tega je treba skrbno spremljati klinični odziv na zdravljenje pri bolnikih, ki prejemajo zdravilo Emtricitabin/dizoproksiltenofovirat Krka s podaljšanim intervalom med odmerki.
English: Signs of osteonecrosis are: joint stiffness joint aches and pains (especially of the hip, knee and shoulder) difficulty with movement → If you notice any of these symptoms tell your doctor.
Slovenian: Znaki osteonekroze so: - okoreli sklepi - bolečine v sklepih (zlasti v kolku, kolenu in rami) - omejena gibljivost → Če opazite katerega od teh simptomov, obvestite zdravnika.
English: Decreases in BMD of spine and changes in bone biomarkers from baseline were significantly greater in the tenofovir disoproxil treatment group at 144 weeks.
Slovenian: Zmanjšanje MKG hrbtenice in spremembe kostnih biomarkerjev od izhodiščne vrednosti so bile po 144 tednih pomembno večje v skupini, ki se je zdravila z dizoproksiltenofoviratom.