FrancophonIA/ELRC3.0 huggingface dataset:
English: 42 film-coated tablets Component of a multipack, can't be sold separately.
Croatian: 42 filmom obložene tablete Sastavni dio višestrukog pakiranja ne može se prodavati odvojeno.
English: Not known (frequency cannot be estimated from the available data): • Inflammation of the pancreas, inflammation of the liver (hepatitis) and psychotic reactions
Croatian: Nepoznate učestalosti (učestalost se ne može procijeniti iz dostupnih podataka): • upala gušterače, upala jetre (hepatitis) i psihotične reakcije
English: Memantine Merz belongs to a group of medicines known as anti-dementia medicines.
Croatian: Memantine Merz se ubraja u skupinu lijekova poznatih kao lijekovi protiv demencije.
English: The next time the dosing pump head is pushed downwards completely (equivalent to one pump actuation), it dispenses the correct dose (1 pump actuation is equivalent to 0.5 ml oral solution, and contains 5 mg of the active substance memantine hydrochloride; fig. 6).
Croatian: Sljedeći put kad se vrh pumpice za doziranje potpuno pritisne prema dolje (što odgovara jednom potisku pumpice), raspršit će se ispravna doza (1 potisak pumpice odgovara 0,5 ml oralne otopine i sadrži 5 mg djelatne tvari memantinklorida; sl. 6).
English: The solution thus dispensed is discarded.
Croatian: Otopina raspršena na ovaj način se baca.
English: What you need to know before you take Memantine Merz Do not take Memantine Merz
Croatian: ŠTO MORATE ZNATI PRIJE NEGO POČNETE UZIMATI MEMANTINE MERZ Nemojte uzimati Memantine Merz
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER FOR TABLETS
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP BLISTER ZA TABLETE
English: Renal handling also involves tubular reabsorption, probably mediated by cation transport proteins.
Croatian: Prolaz memantina kroz bubreg također uključuje i tubularnu reapsorpciju, vjerojatno posredovanu kationskim transportnim proteinima.
English: To unlock, turn the pump head in the direction of the arrow until it cannot be turned any further (about one eighth of a turn, fig. 4).
Croatian: Da bi se otključao, okrenite vrh pumpice u smjeru strelice, sve do točke u kojoj se ne može okrenuti dalje (za oko jednu osminu okretaja, sl. 4).
English: Dose titration
Croatian: Titriranje doze
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar pojedine skupine učestalosti, nuspojave su poredane od ozbiljnijih prema manje ozbiljnima.
English: Elevated liver function test
Croatian: Često povišene vrijednosti testova jetrene funkcije
English: 50 ml oral solution Component of a multipack, can't be sold separately.
Croatian: 50 ml oralna otopina Sastavni dio višestrukog pakiranja ne može se prodavati odvojeno.
English: Correct use of the dosing pump:
Croatian: Ispravna uporaba pumpice za doziranje:
English: Other medicines and Memantine Merz
Croatian: Drugi lijekovi i Memantine Merz
English: The solution should be taken with a little water.
Croatian: Otopinu treba uzeti s malo vode.
English: In rats, foetal growth reduction was noted at exposure levels, which are identical or slightly higher than at human exposure.
Croatian: Kod štakora je zabilježeno smanjenje rasta fetusa pri izloženosti dozama jednakim ili nešto višim od onih primijenjenih kod ljudi.
English: 7 film-coated tablets.
Croatian: 7 filmom obloženih tableta.
English: In a study using orally administered 14C-memantine, a mean of 84% of the dose was recovered within 20 days, more than 99% being excreted renally.
Croatian: U ispitivanju u kojem je korišten oralno primijenjen 14C-memantin, uklonjeno je prosječno 84% doze unutar 20 dana, a više od 99% izlučeno je putem bubrega.
English: Each pack contains 28 film-coated tablets in 4 PVDC/PE/PVC/Al-blister or PP/Al-blisters with 7 filmcoated tablets of 5 mg, 7 film-coated tablets of 10 mg, 7 film-coated tablets of 15 mg and 7 film-coated tablets of 20 mg.
Croatian: Svako pakiranje sadržava 28 filmom obloženih tableta u 4 PVDC/PE/PVC/Al-blistera ili PP/Al-blistera sa 7 filmom obloženih tableta od 5 mg, 7 filmom obloženih tableta od 10 mg, 7 filmom obloženih tableta od 15 mg i 7 filmom obloženih tableta od 20 mg.
English: Pancreatitis2
Croatian: Nepoznato pankreatitis2
English: Multipack 840 (20 packs of 42) film-coated tablets
Croatian: Višestruko pakiranje od 840 (20 pakiranja po 42) filmom obloženih tableta
English: The dosing pump may only be used with the memantine hydrochloride solution in the bottle provided, not for other substances or containers.
Croatian: Pumpica za doziranje može se koristiti samo za otopinu memantinklorida u predviđenoj boci, ne za druge tvari ili spremnike.
English: This dose is increased in the second week to two pump actuations once daily (1 x 10 mg), and in the third week to three pump actuations (1 x 15 mg) once daily.
Croatian: Ova doza se u drugom tjednu povećava na dva potiska pumpice jednom dnevno (1 x 10 mg), a u trećem tjednu na tri potiska pumpica jednom dnevno (1 x 15 mg).
English: Furthermore, Memantine Merz has minor to moderate influence on the ability to drive and use machines such that outpatients should be warned to take special care.
Croatian: Nadalje, Memantine Merz ima blagi do umjereni utjecaj na sposobnost upravljanja vozilima i rada sa strojevima pa ambulantne bolesnike treba upozoriti da na to obrate posebnu pozornost.
English: In patients with mild or moderate hepatic impaired function (Child-Pugh A and Child-Pugh B) no dose adjustment is needed.
Croatian: Kod bolesnika s blagim ili umjerenim oštećenjem jetrene funkcije (Child-Pugh A i Child-Pugh B) nije potrebna prilagodba doze.
English: In a clinical study in young healthy subjects no relevant effect of memantine on the pharmacokinetics of galantamine was observed.
Croatian: U kliničkom ispitivanju na mladim zdravim ispitanicima nije uočen značajan učinak memantina na farmakokinetiku galantamina.
English: These factors include drastic changes in diet, e.g. from a carnivore to a vegetarian diet, or a massive ingestion of alkalising gastric buffers.
Croatian: Ti čimbenici uključuju drastičnu promjenu načina prehrane, npr. prelazak s mesne na vegetarijansku prehranu ili uzimanje izrazito velike količine alkalizirajućih želučanih pufera.
English: The dosing pump must only be used with the Memantine Merz solution in the bottle provided, not for other substances or containers.
Croatian: Pumpica za doziranje smije se koristiti samo za Memantine Merz otopinu u predviđenoj boci, a ne za druge tvari ili spremnike.
English: Component of a multipack, can't be sold separately.
Croatian: Sastavni dio višestrukog pakiranja ne može se prodavati odvojeno.
English: Only limited experience with overdose is available from clinical studies and post-marketing experience.
Croatian: Iz kliničkih ispitivanja i postmarketinškog iskustva dostupno je samo ograničeno iskustvo u vezi s predoziranjem.
English: What Memantine Merz looks like and contents of the pack
Croatian: Kako Memantine Merz izgleda i sadržaj pakiranja
English: Each tablet contains 5/10/15/20 mg of memantine hydrochloride equivalent to 4.15/8.31/12.46/16.62 mg memantine.
Croatian: Jedna tableta sadržava 5/10/15/20 mg memantinklorida, što odgovara 4,15/8,31/12,46/16,62 mg memantina.
English: Mon → Tue → Wed → Thu → Fri → Sat → Sun
Croatian: Pon → Uto → Sri → Čet → Pet → Sub →Ned
English: At the beginning of treatment you will start by using Memantine Merz 5 mg film-coated tablets once a day.
Croatian: Liječenje ćete započeti korištenjem Memantine Merz filmom obloženih tableta od 5 mg jedanput na dan.
English: Studies in volunteers have demonstrated linear pharmacokinetics in the dose range of 10 to 40 mg. Pharmacokinetic/pharmacodynamic relationship
Croatian: Linearnost Ispitivanja na dobrovoljcima pokazala su linearnu farmakokinetiku u rasponu doza od 10 do 40 mg.
English: When daily doses of 5 to 30 mg were administered, a mean cerebrospinal fluid (CSF)/serum ratio of 0.52 was calculated.
Croatian: Pri primjeni dnevnih doza od 5 do 30 mg izračunata je aritmetička sredina omjera cerebrospinalni likvor (CSL)/serum od 0,52.
English: CARTON AND LABEL FOR 50 ml BOTTLE AS INTERMEDIATE PACK / COMPONENT OF A MULTIPACK (WITHOUT BLUE BOX)
Croatian: KUTIJA I NAJEPNICA ZA BOCU OD 50 ml KAO SREDNJE PAKIRANJE / DIO VIŠESTRUKOG PAKIRANJA (BEZ PLAVOG OKVIRA)
English: For the intended use the dosing pump is only screwed on once when starting the use, and should never be unscrewed.
Croatian: Za namijenjenu uporabu pumpicu za doziranje treba pričvrstiti zavrtanjem samo jednom na početku uporabe te je ne bi više trebalo odvrtati.
English: How to store Memantine Merz Content of the pack and other information
Croatian: Kako čuvati Memantine Merz Sadržaj pakiranja i druge informacije
English: In man, about 80% of the circulating memantine-related material is present as the parent compound.
Croatian: Kod ljudi je oko 80% memantina u cirkulaciji prisutno u nepromijenjenom obliku.
English: In another monotherapy study in mild to moderate Alzheimer's disease a total of 470 patients (MMSE total scores at baseline of 11-23) were randomised.
Croatian: U drugom monoterapijskom ispitivanju blage do umjerene Alzheimerove bolesti randomizirano je ukupno 470 bolesnika (početne vrijednosti ukupnog MMSE od 11-23).
English: OTHER SPECIAL WARNING(S), IF NECESSARY
Croatian: DRUGO (A) POSEBNO (A) UPOZORENJE (A) AKO JE POTREBNO
English: The solution also contains potassium sorbate and sorbitol (E 420).
Croatian: Otopina također sadrži kalijev sorbat i sorbitol (E420).
English: H. Lundbeck AS Tlf: +47 91 300 800
Croatian: Lundbeck AS Tlf: +47 91 300 800
English: Preparing the dosing pump:
Croatian: Priprema pumpice za doziranje:
English: The other ingredients are: potassium sorbate, sorbitol (E 420) and purified water.
Croatian: Drugi sastojci su: kalijev sorbat, sorbitol E420 i pročišćena voda.
English: The bottle with the mounted pump must be kept and transported in an upright position only.
Croatian: Boca s namještenom pumpicom mora se čuvati i prenositi samo u uspravnom položaju.
English: Alkalisation of urine may result from drastic changes in diet, e.g. from a carnivore to a vegetarian diet, or from the massive ingestion of alkalising gastric buffers.
Croatian: Alkalizaciju urina može izazvati drastična promjena načina prehrane, npr. prelazak s mesne na vegetarijansku prehranu ili uzimanje izrazito velike količine alkalizirajućih želučanih pufera.
English: Memantine Merz should be administered orally once a day.
Croatian: Memantine Merz treba primjenjivati na usta jedanput na dan.
English: The dosing pump head can then be released and is ready for the next pump actuation.
Croatian: Nakon toga pumpicu za doziranje možete otpustiti te je spremna za sljedeći potisak.
English: In the overdose cases below 140 mg or unknown dose the patients revealed symptoms from central nervous system (confusion, drowsiness, somnolence, vertigo, agitation, aggression, hallucination and gait disturbance) and/or gastrointestinal origin (vomiting and diarrhoea).
Croatian: U slučajevima predoziranja s dozom manjom od 140 mg ili nepoznatom dozom, bolesnici su opisivali simptome središnjeg živčanog sustava (konfuziju, omamljenost, somnolenciju, vrtoglavicu, agitaciju, agresiju, halucinacije i poremećaj hoda) i/ili gastrointestinalne simptome (povraćanje i proljev).
English: three pump actuations week 4 and beyond four pump actuations
Croatian: 4. tjedan i nadalje četiri potiska pumpice
English: Memantine Merz oral solution is presented as a clear, colourless to light yellowish solution.
Croatian: Memantine Merz oralna otopina je bistra, bezbojna do svijetlo žućkasta otopina.
English: If you suffer from renal impairment (kidney problems), your doctor should closely monitor your kidney function and if necessary adapt the memantine doses accordingly.
Croatian: Ako imate oštećenje bubrežne funkcije (probleme s bubrezima), liječnik treba pažljivo funkciju Vaših bubrega i ovisno o njoj prilagoditi dozu memantina, ako je to potrebno.
English: The most frequently occurring adverse reactions with a higher incidence in the Memantine Merz group than in the placebo group were dizziness (6.3% vs 5.6%, respectively), headache (5.2% vs 3.9%), constipation (4.6% vs 2.6%), somnolence (3.4% vs 2.2%) and hypertension (4.1% vs 2.8%).
Croatian: Nuspojave koje su se najčešće pojavljivale s većom incidencijom u skupini bolesnika liječenih Memantine Merz nego u skupini koja je uzimala placebo bile su omaglica (6,3% naspram 5,6%), glavobolja (5,2% naspram 3,9%), konstipacija (4,6% naspram 2,6%), somnolencija (3,4% naspram 2,2%) i hipertenzija (4,1% naspram 2,8%).
English: If you forget to take Memantine Merz
Croatian: Ako ste zaboravili uzeti Memantine Merz
English: From the fourth week the recommended dose is four pump actuations once daily (1 x 20 mg).
Croatian: Od četvrtog tjedna, preporučena doza je četiri potiska pumpice jednom dnevno (1 x 20 mg).
English: EU/1/12/799/025 28 film-coated tablets EU/1/12/799/026 28 film-coated tablets
Croatian: EU/1/12/799/025 28 filmom obloženih tableta EU/1/12/799/026 28 filmom obloženih tableta
English: Each pack of 28 film-coated tablets for a 4 week treatment schedule contains: 7 x Memantine Merz 5 mg
Croatian: Svako pakiranje s 28 filmom obloženih tableta za plan liječenja za 4 tjedna sadrži: 7 x Memantine Merz 5 mg
English: These compounds act at the same receptor system as memantine, and therefore adverse reactions (mainly central nervous system (CNS)-related) may be more frequent or more pronounced (see also section 4.5).
Croatian: Ovi spojevi djeluju na isti sustav receptora kao i memantin pa bi nuspojave (uglavnom povezane sa središnjim živčanim sustavom (SŽS)) mogle biti učestalije ili izraženije (vidjeti također dio 4.5).
English: Oy H. Lundbeck Ab Puh/Tel: +358 2 276 5000
Croatian: Lundbeck Ab Puh/Tel: +358 2 276 5000
English: Cardiac failure
Croatian: Srčani poremećaji
English: The use of memantine in pregnant women is not recommended.
Croatian: Trudnicama se ne preporučuje upotreba memantina.
English: Therefore, the pump must be prepared (primed) by pushing the dosing pump head down completely five times in succession (fig. 5).
Croatian: Stoga se pumpica mora pripremiti potpunim pritiskom vrha pumpice za doziranje prema dolje, pet puta zaredom (sl. 5).
English: H. Lundbeck AB Tel: +46 4225 4300
Croatian: Lundbeck AB Tel: +46 4225 4300
English: Memantine hydrochloride
Croatian: memantinklorid
English: The bottle should be placed on a flat, horizontal surface, for example a table top, and only use it in a vertical position.. A glass with a little water or a spoon should be hold below the nozzle and the dosing pump head has to be pushed down in a firm but calm and steady manner (not too slowly) right down to the stop (fig. 7, fig. 8).
Croatian: Ispod mlaznice treba staviti čašu s malo vode ili žlicu, a vrh pumpice za doziranje treba pritisnuti prema dolje, snažno, ali smireno i mirno (ne presporo) sve do kraja (sl. 7, sl. 8).
English: Clinical studies
Croatian: KLINIČKI PODACI
English: Phospholipidosis in pulmonary macrophages due to accumulation of memantine in lysosomes was observed in rodents.
Croatian: Kod glodavaca je primijećena fosfolipidoza u plućnim makrofazima zbog nakupljanja memantina u lizosomima.
English: From the fourth week on, the usual dose is 2 tablets once a day (1x 20 mg).
Croatian: Od četvrtog tjedna nadalje uobičajena doza je 2 tablete jedanput na dan (1 x 20 mg).
English: Excipients: The oral solution contains sorbitol.
Croatian: Pomoćne tvari: oralna otopina sadržava sorbitol.
English: Immune systeme disorders
Croatian: Poremećaji imunološkog sustava
English: What Memantine Merz is and what it is used for How does Memantine Merz work
Croatian: ŠTO JE MEMANTINE MERZ I ZA ŠTO SE KORISTI Kako djeluje Memantine Merz
English: SYSTEM ORGAN CLASS
Croatian: KLASIFIKACIJA ORGANSKIH SUSTAVA
English: Hold the dosing pump onto the neck of the bottle and screw it clockwise until it fits firmly (fig. 3).
Croatian: Držite pumpicu za doziranje na vratu boce i zavrćite ju u smjeru kazaljke na satu dok nije pričvršćena (sl. 3).
English: Then the dosing pump needs to be hold onto the neck of the bottle and screwed clockwise until it is firmly attached (fig 3).
Croatian: Zatim pumpicu za doziranje treba držati na vratu boce i zavrtati u smjeru kazaljke na satu dok nije pričvršćena (sl. 3).
English: What Memantine Merz is and what it is used for What you need to know before you take Memantine Merz How to take Memantine Merz Possible side effects
Croatian: Što je Memantine Merz i za što se koristi Što morate znati prije nego počnete uzimati Memantine Merz Kako uzimati Memantine Merz
English: Memantine is a voltage-dependent, moderate-affinity uncompetitive NMDA-receptor antagonist.
Croatian: Memantin je nekompetitivni antagonist NMDA-receptora, umjerenog afiniteta i ovisan o voltaži.
English: Multipack 840 (20 packs of 42) film-coated tablets Multipack 980 (10 packs of 98) film-coated tablets Multipack 1000 (20 packs of 50) film-coated tablets
Croatian: Višestruko pakiranje od 840 (20 pakiranja po 42) filmom obloženih tableta Višestruko pakiranje od 980 (10 pakiranja po 98) filmom obloženih tablet Višestruko pakiranje od 1000 (20 pakiranja po 50) filmom obloženih tableta
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING INNER CARTON FOR BLISTER PACK; front and backside
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU UNUTARNJA KUTIJA ZA BLISTER; prednja i stražnja srana
English: One treatment initiation pack contains 28 tablets in 4 blisters with 7 tablets of Memantine Merz 5 mg, 7 tablets of Memantine Merz 10 mg, 7 tablets of Memantine Merz 15 mg and 7 tablets of Memantine Merz 20 mg.
Croatian: Jedno pakovanje za početak liječenja sadržava 28 tableta u 4 blistera sa 7 Memantine Merz tableta od 5 mg, 7 Memantine Merz tableta od 10 mg, 7 Memantine Merz tableta od 15 mg i 7 Memantine Merz tableta od 20 mg.
English: Common (may affect up to 1 in 10 users):
Croatian: Često (mogu se javiti u do 1 na 10 osoba):
English: Memantine Merz belongs to a group of medicines called NMDA-receptor antagonists.
Croatian: Memantine Merz spada u skupinu lijekova poznatih kao antagonisti NMDA
English: This is increased to one tablet once a day (1x 10 mg) in the second week and to 1 and a half tablet once a day in the third week.
Croatian: Ova doza se povećava na jednu tabletu jedanput na dan (1 x 10 mg) u drugom tjednu te na jednu i pol tabletu jednom dnevno u trećem tjednu.
English: Film-coated tablet.
Croatian: Filmom obložena tablete.
English: A pivotal monotherapy study of memantine in the treatment of mild to moderate Alzheimer's disease (MMSE total scores at baseline of 10 to 22) included 403 patients.
Croatian: U pivotalno ispitivanje monoterapije memantinom u liječenju blage do umjerene Alzheimerove bolesti (početne vrijednosti ukupnog MMSE od 10 do 22) bila su uključena 403 bolesnika.
English: Measure the dose onto a spoon or into a glass of water, using the pump.
Croatian: Pomoću pumpice izmjerite dozu u žlicu ili u čašu vode.
English: The active substance is memantine hydrochloride.
Croatian: Djelatna tvar je memantinklorid.
English: These events have been reported in patients treated with Memantine Merz.
Croatian: Ovi su događaji prijavljivani kod bolesnika liječenih Memantine Merzom.
English: Daily doses of 20 mg lead to steady-state plasma concentrations of memantine ranging from 70 to 150 ng/ml (0.5 - 1 µmol) with large interindividual variations.
Croatian: Dnevne doze od 20 mg dovode do plazmatskih koncentracija memantina u stanju dinamičke ravnoteže u rasponu od 70 do 150 ng/ml (0,5-1 µmol) s velikim interindividualnim razlikama.
English: The solution may only be dispensed in the unlocked position.
Croatian: Otopina se može raspršiti samo u otključanom položaju.
English: Pack sizes of 14, 28, 30, 42, 50, 56, 98, 100, 112, and multipacks containing 840 (20 x 42), 980 (10 x 98) or 1000 (20 x 50) tablets are presented.
Croatian: Postoje veličine pakiranja od 14, 28, 30, 42, 50, 56, 98, 100, 112, višestruko pakiranje od 840 (20 x 42), 980 (10 x 98) ili 1000 (20 x 50) tableta.
English: No cytochrome P 450 catalysed metabolism has been detected in vitro.
Croatian: In vitro nije otkriven metabolizam kataliziran citokromom P 450.
English: Memantine Merz should be administered once a day and should be taken at the same time every day.
Croatian: Merz se mora primjenjivati jednom dnevno i potrebno ju je uzimati svaki dan u isto vrijeme.
English: The dosing pump is only screwed on once when starting the use, and should never be unscrewed.
Croatian: Pumpicu za doziranje treba pričvrstiti zavrtanjem jednom na početku uporabe te je više ne bi trebalo odvrtati.
English: The other ingredients for Memantine Merz 5/10/15 and 20 mg film-coated tablets are microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate, all in the tablet core; and hypromellose, macrogol 400, titanium dioxide (E 171) and additional for Memantine Merz 10 mg film-coated tablets is iron oxide yellow (E172) and for Memantine Merz 15 mg and Memantine Merz 20 mg film-coated tablets are iron oxide yellow and red (E 172), all in the tablet coating.
Croatian: Drugi sastojci Memantine Merz 5/ 10/ 15 i 20 mg filmom obloženih tableta su mikrokristalična celuloza, umrežena karmelozanatrij, koloidni bezvodni silicijev dioksid i magnezijev stearat sve u jezgri tablete; te hipromeloza, makrogol 400, titanijev dioksid (E171) i dodatno za Memantine Merz 10 mg filmom obložene tablete žuti željezov oksid (E172), a za Memantine Merz 15 mg i Memantine Merz 20 mg filmom obložene tablete žuti i crveni željezov oksid (E172), sve u ovojnici tablete.
English: No data on the use of memantine in patients with severe hepatic impairment are available.
Croatian: Nisu dostupni podaci o primjeni memantina kod bolesnika s teškim oštećenjem jetrene funkcije.
English: EU/1/12/799/018 840 film-coated tablets (20 packs of 42) EU/1/12/799/024 840 film-coated tablets (20 packs of 42)
Croatian: EU/1/12/799/018 840 filmom obloženih tableta (20 pakiranja po 42) EU/1/12/799/024 840 filmom obloženih tableta (20 pakiranja po 42)
English: 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 42 film-coated tablets 50 film-coated tablets 56 film-coated tablets 98 film-coated tablets 100 film-coated tablets 112 film-coated tablets
Croatian: 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 42 filmom obložene tablete 50 filmom obloženih tableta 56 filmom obloženih tableta 98 filmom obloženih tableta 100 filmom obloženih tableta 112 filmom obloženih tableta
English: Memantine Merz is used for the treatment of patients with moderate to severe Alzheimer's disease.
Croatian: Merz se koristi za liječenje bolesnika s umjerenom do teškom Alzheimerovom bolešću.
English: The following Adverse Reactions listed in the Table below have been accumulated in clinical studies with Memantine Merz and since its introduction in the market.
Croatian: U sljedećoj tablici prikazane su nuspojave prikupljene tijekom kliničkih ispitivanja s Memantine Merzom i nakon stavljanja lijeka u promet.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR 28 TABLETS - TREATMENT INITIATION PACK - 4 WEEK TREATMENT SCHEDULE
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA ZA 28 TABLETA - PAKIRANJE ZA POČETAK
English: For memantine, no clinical data on exposed pregnancies are available.
Croatian: Nema kliničkih podataka o izloženosti memantinu u trudnoći.
English: When patients were identified with concurrent worsening in all three domains, results showed a statistically significant effect of memantine in preventing worsening, as twice as many placebo-treated patients as memantine-treated patients showed worsening in all three domains (21% vs. 11%, p<0.0001).
Croatian: U skupini bolesnika liječenih placebom bilo je dvostruko više pogoršanja u sva tri područja nego u skupini bolesnika liječenih memantinom (21% naspram 11%, p<0,0001).