FrancophonIA/ELRC3.0 huggingface dataset:
English: Frequency categories are defined as follows: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000) and not known (frequency cannot be estimated from the available data).
Croatian: Kategorije učestalosti definirane su kako slijedi: vrlo često (≥ 1/10), često (≥ 1/100 do < 1/10), manje često (≥ 1/1000 do < 1/100), rijetko (≥ 1/10 000 do < 1/1000) i nepoznato (učestalost se ne može procijeniti iz dostupnih podataka).
English: Your doctor will carefully consider whether to treat you with REZOLSTA.
Croatian: Vaš će liječnik pažljivo procijeniti hoće li Vas liječiti lijekom REZOLSTA.
English: When administered with food, the relative exposure of darunavir is 1.7-fold higher as compared to intake without food.
Croatian: Kada se primjenjuje s hranom, relativna izloženost darunaviru je 1,7-puta veća u usporedbi na unos bez hrane.
English: Always take with food.
Croatian: Uvijek uzmite tabletu s hranom.
English: REZOLSTA has only been used in limited numbers of patients 65 years or older.
Croatian: REZOLSTA je primjenjivana samo kod ograničenog broja bolesnika u dobi od 65 godina ili starijih.
English: Therefore, REZOLSTA tablets should be taken with food.
Croatian: Stoga se tablete lijeka REZOLSTA moraju uzimati s hranom.
English: Some side effects are typical for HIV medicines in the same family as REZOLSTA.
Croatian: Neke su nuspojave tipične za lijekove za HIV koji spadaju u istu skupinu kao i REZOLSTA.
English: Consideration should be given to official guidance on the appropriate treatment of tuberculosis in HIV infected patients.
Croatian: U obzir se trebaju uzeti službene smjernice za prikladno liječenje tuberkuloze u bolesnika zaraženih HIV-om.
English: Inflammation of the pancreas (pancreatitis) has been reported in up to 1 patient in 100.
Croatian: Upala gušterače (pankreatitis) bila je prijavljena u do 1 bolesnika na 100.
English: Studies in animals have demonstrated that cobicistat is excreted in milk.
Croatian: Ispitivanja na životinjama su pokazala da se kobicistat izlučuje u mlijeko.
English: C-cobicistat, 99% of circulating radioactivity in plasma was unchanged cobicistat.
Croatian: C-kobicistata, 99% cirkulirajuće radioaktivnosti u plazmi bio je nepromijenjeni kobicistat.
English: Treatment of overdose with REZOLSTA consists of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient.
Croatian: Liječenje predoziranja lijekom REZOLSTA sastoji se od općih potpornih mjera koje uključuju praćenje vitalnih znakova i promatranje kliničkog statusa bolesnika.
English: When didanosine is co-administered with REZOLSTA, didanosine should be administered on an empty stomach 1 hour before or 2 hours after REZOLSTA (which is administered with food).
Croatian: Kada se didanozin primjenjuje istodobno s lijekom REZOLSTA, didanozin treba primijeniti na prazan želudac 1 sat prije ili 2 sata poslije lijeka REZOLSTA (koji se uzima s hranom).
English: There was no effect on mating or fertility in animals (see section 5.3).
Croatian: Nije bilo učinaka na parenje ili plodnost u životinja (vidjeti dio 5.3).
English: If you belong to this age group, please discuss with your doctor if you can use REZOLSTA.
Croatian: Ako pripadate toj dobnoj skupini, molimo Vas da s liječnikom razmotrite smijete li uzimati lijek REZOLSTA.
English: Second trimester of pregnancy N=7
Croatian: Drugo tromjesečje trudnoće (n=7)
English: Other severe side effects, seen up to 1 patient in 10, were diabetes.
Croatian: Ostale teške nuspojave, zabilježene u do 1 bolesnika na 10, bile su šećerna bolest.
English: REZOLSTA does not require any special storage conditions.
Croatian: REZOLSTA ne zahtijeva posebne uvjete čuvanja.
English: There are no adequate and well controlled trials with darunavir, or cobicistat, in pregnant women.
Croatian: Nisu provedena odgovarajuća i dobro kontrolirana ispitivanja s darunavirom ili kobicistatom u trudnica.
English: However, only limited data were available in patients above the age of 65 years.
Croatian: Međutim, za bolesnike iznad dobi od 65 godina bili su dostupni samo ograničeni podaci.
English: Always use this medicine exactly as your doctor, pharmacist or nurse has told you.
Croatian: Uvijek uzmite ovaj lijek točno onako kako Vam je rekao liječnik, ljekarnik ili medicinska sestra.
English: REZOLSTA might increase the risk of bleeding.
Croatian: REZOLSTA može povećati rizik krvarenja.
English: REZOLSTA is used to treat adults 18 years or older who are infected by HIV (see How to take REZOLSTA).
Croatian: REZOLSTA se koristi za liječenje odraslih u dobi od 18 godina i starijih koji su zaraženi HIV-om (pogledajte dio Kako uzimati lijek REZOLSTA)
English: The European Medicines Agency has deferred the obligation to submit the results of studies with REZOLSTA in all subsets of the paediatric population in the condition of treatment of HIV-1 infection.
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka REZOLSTA u svim podskupinama pedijatrijske populacije za liječenje HIV-1 infekcije.
English: REZOLSTA might increase sugar levels in the blood.
Croatian: REZOLSTA može povisiti razine šećera u krvi.
English: However, unbound darunavir concentrations were approximately 55% (Child-Pugh Class A) and 100% (Child-Pugh Class B) higher, respectively.
Croatian: Međutim, koncentracije nevezanog darunavira bile su približno 55% (Child-Pugh stadij A) i 100% (Child-Pugh stadij B) više.
English: An increase in serum creatinine due to the inhibitory effect of cobicistat generally does not exceed 0.4 mg/dl.
Croatian: Porast kreatinina u serumu radi inhibitornog učinka kobicistata općenito ne prelazi 0,4 mg/dl.
English: The effects of REZOLSTA might be reduced if you take any of the following products.
Croatian: Učinci lijeka REZOLSTA mogu se smanjiti ako uzimate bilo koji od sljedećih lijekova.
English: Please contact your doctor whenever you develop a rash.
Croatian: Molimo obratite se svom liječniku uvijek kada Vam se pojavi osip.
English: H2-RECEPTOR ANTAGONISTS Cimetidine
Croatian: ANTAGONISTI H2-RECEPTORA Cimetidin
English: Pharmacotherapeutic group: Antivirals for systemic use, antivirals for treatment of HIV infection, combinations ATC code: J05AR14
Croatian: Farmakoterapijska skupina: Antivirusni lijekovi za sistemsku primjenu, antivirotici za liječenje infekcije HIV-om, kombinacije ATK oznaka: J05AR14
English: Description of clinical studies of REZOLSTA in adults
Croatian: Opis kliničkih ispitivanja lijeka REZOLSTA u odraslih
English: INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS Medicinal products by therapeutic areas
Croatian: INTERAKCIJE I PREPORUKE DOZA UZ DRUGE LIJEKOVE Lijekovi prema terapijskim područjima
English: Darunavir belongs to a group of HIV medicines called ‘protease inhibitors' which work by reducing the amount of HIV in your body to a very low level.
Croatian: Darunavir pripada skupini lijekova za HIV koji se nazivaju inhibitorima proteaze, a djeluje tako što smanjuje količinu virusa HIV-a u Vašem tijelu na vrlo nisku razinu.
English: Darunavir was rapidly absorbed following oral administration of REZOLSTA in healthy volunteers.
Croatian: Darunavir se apsorbirao brzo nakon peroralne primjene lijeka REZOLSTA u zdravih dobrovoljaca.
English: The substantial reduction in darunavir exposure may result in virological failure and an increased risk of mother to child transmission of HIV infection.
Croatian: Znatno smanjenje izloženosti darunaviru može rezultirati virološkim neuspjehom i povećanim rizikom za prijenos HIV infekcije s majke na dijete.
English: Further dosage reduction of rifabutin has not been studied.
Croatian: Dodatno smanjenje doze rifabutina nije ispitivano.
English: Midazolam (parenteral) Zolpidem
Croatian: Midazolam (parenteralni) Zolpidem
English: All of these serious ADRs occurred in one (0.1%) subject except for rash in 4 (0.6%) subjects.
Croatian: Sve ove ozbiljne nuspojave na lijek pojavile su se kod jednog (0,1%) ispitanika osim osipa kod 4 (0,6%) ispitanika.
English: It is given with cobicistat, which increases the amount of darunavir in your blood.
Croatian: Daje se s kobicistatom koji povećava količinu darunavira u Vašoj krvi.
English: Studies in rats have demonstrated that darunavir is excreted in milk and at high levels (1,000 mg/kg/day) resulted in toxicity.
Croatian: Ispitivanja na štakorima pokazala su da se darunavir izlučuje u mlijeko i u visokim razinama (1000 mg/kg/dan) dovodi do toksičnosti.
English: Maximum plasma concentration of darunavir in the presence of cobicistat is generally achieved within 3 to 4.5 hours.
Croatian: Maksimalna koncentracija darunavira u plazmi uz prisustvo kobicistata općenito se postiže unutar 3 do 4,5 sati.
English: Do not use this medicine after 6 weeks of first opening the bottle.
Croatian: Nemojte koristiti ovaj lijek nakon što prođe 6 tjedana od prvog otvaranja boce.
English: Pharmacokinetics of cobicistat have not been fully evaluated in older people (65 years of age and older).
Croatian: Kobicistat Farmakokinetika kobicistata nije u potpunosti ispitana u starijih osoba (u starosti od 65 i više godina).
English: Dose-related increases in the incidences of hepatocellular adenomas and carcinomas were observed in males and females of both species.
Croatian: S dozom povezana povišenja incidencije hepatocelularnog adenoma i karcinoma bila su opažena kod mužjaka i ženki obje vrste.
English: Make sure that you check the following points and tell your doctor if any of these apply to you.
Croatian: Svakako provjerite sljedeće točke i upozorite liječnika odnosi li se neka od njih na Vas.
English: The decreased susceptibility to darunavir of the emerging viruses in the selection experiment could not be explained by the emergence of these protease mutations.
Croatian: Snižena osjetljivost nastajućih virusa na darunavir u eksperimentu odabira ne može se objasniti nastankom ovih mutacija proteaza.
English: What you need to know before you take REZOLSTA
Croatian: Što morate znati prije nego počnete uzimati lijek REZOLSTA
English: - Oestrogen-based hormonal contraceptives and hormone replacement therapy.
Croatian: - hormonska kontracepcija na bazi estrogena i hormonska nadomjesna terapija.
English: Cobicistat has no detectable antiviral activity against HIV-1 and does not antagonise the antiviral effect of darunavir.
Croatian: Kobicistat nema detektabilnu antivirusnu aktivnost protiv HIVa-1 i ne antagonizira antivirusni učinak darunavira.
English: Other medicines and REZOLSTA Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli bilo koje druge lijekove.
English: In more than half of the reported cases, treatment with HIV PIs was continued or reintroduced if treatment had been discontinued.
Croatian: U više od polovice prijavljenih slučajeva, liječenje inhibitorima proteaze HIV-a je nastavljeno ili je ponovno uvedeno u slučaju prekida liječenja.
English: If you have difficulty swallowing REZOLSTA, tell your doctor.
Croatian: Ako imate poteškoća pri gutanju lijeka REZOLSTA, recite to svom liječniku.
English: If REZOLSTA is missed within 12 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of REZOLSTA with food as soon as possible.
Croatian: Ako je REZOLSTA propuštena unutar 12 sati od uobičajenog vremena uzimanja, bolesnike se mora uputiti da propisanu dozu lijeka REZOLSTA uzmu s hranom što je prije moguće.
English: Concentrations of these medicinal products may be increased when co-administered with REZOLSTA resulting in the potential for increased adverse events usually associated with these medicinal products.
Croatian: Koncentracije tih lijekova mogu se povisiti kada se primjenjuju istodobno s lijekom REZOLSTA potencijalno rezultirajući povećanjem štetnih događaja koji su obično povezani s tim lijekovima.
English: Warnings and precautions Talk to your doctor, pharmacist or nurse before taking REZOLSTA.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete lijek REZOLSTA.
English: Pink oval shaped tablet of 23 mm x 11.5 mm, debossed with “800” on one side and “TG” on the other side.
Croatian: Ružičasta tableta ovalnog oblika od 23 mm x 11,5 mm, s utisnutim “800” na jednoj strani i “TG” na drugoj strani.
English: In the dog, no major toxicity findings or target organs were identified up to exposures equivalent to clinical exposure at the recommended dose.
Croatian: Kod pasa nije nađena veća toksičnost niti su identificirani ciljni organi pri izloženostima jednakim kliničkoj izloženosti pri preporučenoj dozi.
English: REZOLSTA should not be used in combination with the individual components of REZOLSTA (darunavir or cobicistat).
Croatian: REZOLSTA se ne smije uzimati u kombinaciji s individualnim komponentama lijeka REZOLSTA (darunavirom ili kobicistatom).
English: Anti-HIV medicines may make you feel better.
Croatian: Uz liječenje lijekovima protiv HIV-a možete se početi osjećati bolje.
English: Cobicistat is 97 to 98% bound to human plasma proteins and the mean plasma to blood-drug concentration ratio was approximately 2.
Croatian: Kobicistat je 97 do 98% vezan na proteine plazme u ljudi, a srednja vrijednost omjera koncentracije lijeka između plazme i krvi je bila otprilike 2.
English: Due to uncertainties regarding the rate of development of the human blood brain barrier and liver enzymes REZOLSTA should not be used in paediatric patients below 3 years of age.
Croatian: S obzirom na nesigurnost vezanu uz poznavanje brzine razvoja ljudske krvno-moždane barijere i jetrenih enzima, REZOLSTA se ne smije primjenjivati pedijatrijskim bolesnicima mlađima od 3 godine starosti.
English: REZOLSTA should be used with caution in patients with a known sulphonamide allergy.
Croatian: REZOLSTA se mora primjenjivati s oprezom kod bolesnika s poznatom alergijom na sulfonamide.
English: Treatment with REZOLSTA will improve your immune system (your body's natural defences) and reduce the risk of developing illnesses linked to HIV infection, but REZOLSTA is not a cure for HIV infection.
Croatian: Vaš imunološki sustav (prirodni obrambeni mehanizam Vašeg tijela) i smanjiti rizik od razvoja bolesti koje su vezane uz HIV infekciju, ali REZOLSTA neće izliječiti HIV infekciju.
English: Third trimester of pregnancy N=6
Croatian: Treće tromjesečje trudnoće (n=6)
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer to the relevant product information for these medicinal products.
Croatian: U slučaju istodobne antivirusne terapije za hepatitis B ili C, potrebno je slijediti relevantne informacije o lijeku koji postoje za te lijekove.
English: - Clonazepam (to prevent seizures).
Croatian: - klonazepam (za sprječavanje napadaja).
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately so you can be given the necessary treatment.
Croatian: Ako primjetite bilo koji simptom infekcije ili drugi simptom poput mišićne slabosti, slabosti koja počinje u šakama i stopalima te se širi gore prema trupu tijela, lupanja srca, tremora ili hiperaktivnosti, molimo Vas odmah obavijestite liječnika i kako bi Vam pružio potrebno liječenje.
English: The clinical relevance of this increase is unknown, therefore, darunavir/ritonavir should be used with caution.
Croatian: Klinički značaj ovog povišenja nije poznat, stoga se darunavir/ritonavir moraju primjenjivati s oprezom.
English: Therapy should be initiated by a healthcare provider experienced in the management of HIV infection.
Croatian: Terapiju mora započeti liječnik s iskustvom u liječenju HIV infekcije.
English: TMC114FD2HTX3001 (darunavir/cobicistat arm)
Croatian: TMC114FD2HTX3001 (skupina koja je primala darunavir/kobicistat)
English: Ethinylestradiol (0.02 mg once daily)
Croatian: Etinilestradiol (0,02 mg jedanput na dan)
English: Clinical monitoring is recommended, as maintenance therapy may need to be adjusted in some patients.
Croatian: Preporučuje se kliničko praćenje, jer će se za neke bolesnike možda morati prilagoditi terapija održavanja.
English: The median terminal plasma half-life of cobicistat following administration of REZOLSTA is approximately 3-4 hours.
Croatian: Medijan terminalnog poluvijeka kobicistata u plazmi nakon primjene lijeka REZOLSTA iznosi oko 3-4 sata.
English: Population pharmacokinetic analysis showed a slightly higher darunavir exposure (16.8%) in HIV infected females compared to males.
Croatian: Analiza populacijske farmakokinetike pokazala je neznatno višu izloženost darunaviru (16,8%) kod HIV-om inficiranih žena u usporedbi s muškarcima.
English: If you notice within 12 hours, you must take the tablet immediately.
Croatian: Ako primijetite da niste uzeli lijek unutar 12 sati, tabletu morate uzeti odmah.
English: White, high density polyethylene (HDPE) bottle containing 30 tablets, fitted with polypropylene (PP) child resistant closure with induction seal.
Croatian: Bijela boca od polietilena visoke gustoće (HDPE) koja sadrži 30 tableta, opremljena polipropilenskim (PP) zatvaračem sigurnim za djecu sa zalijepljenom zaštitnom folijom.
English: REZOLSTA must not be used with another antiviral medicine that contains a booster or another antiviral that requires boosting.
Croatian: REZOLSTA se ne smije uzimati s drugim antivirusnim lijekom koji sadrži pojačivač ili drugim antivirotikom kojemu je potrebno pojačanje.
English: The type of food does not affect exposure to REZOLSTA.
Croatian: Vrsta hrane ne utječe na izloženost lijeku REZOLSTA.
English: Do not take REZOLSTA - if you are allergic to darunavir, cobicistat or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati lijek REZOLSTA - ako ste alergični na darunavir, kobicistat ili neki drugi sastojak ovog lijeka (naveden u dijelu
English: *study was done with tenofovir disoproxil fumarate
Croatian: *ispitivanje je provođeno s tenofovirdizoproksilfumaratom
English: Do not use this medicine after the expiry date which is stated on the carton and on the bottle after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i boci iza oznake „EXP“.
English: Based on animal studies, no effect on mating or fertility is expected with REZOLSTA.
Croatian: Temeljeno na ispitivanjima na životinjama, ne očekuje se učinak lijeka REZOLSTA na parenje ili plodnost.
English: Following oral administration of REZOLSTA in healthy volunteers, maximum plasma concentrations of cobicistat were observed 2 to 5 hours post-dose.
Croatian: Nakon peroralne primjene lijeka REZOLSTA u zdravih dobrovoljaca, maksimalna koncentracija u plazmi bila je zapažena 2 do 5 sati nakon uzimanja doze.
English: In the Phase III single-arm trial (GS-US-216-130), a decrease in eGFRCG was noted at week 2, which remained stable through week 48.
Croatian: U ispitivanju faze III s jednom skupinom (GS-US-216-130), zabilježen je pad eGFRCG u 2. tjednu, koji je ostao stabilan do 48. tjedna.
English: People taking REZOLSTA may develop a skin rash.
Croatian: U osoba koje uzimaju lijek REZOLSTA može se razviti kožni osip.
English: Data based on analyses at week 96
Croatian: Podaci dobiveni analizama u 96. tjednu
English: Iron oxide black
Croatian: Željezov oksid, crni
English: The below list of examples of drug drug interactions is not comprehensive and therefore the label of each drug that is co-administered with REZOLSTA should be consulted for information related to the route of metabolism, interaction pathways, potential risks, and specific actions to be taken with regards to co-administration.
Croatian: Donja tablica primjera interakcija s drugim lijekovima nije sveobuhvatna, stoga je potrebno proučiti informacije o lijeku za svaki lijek koji se primjenjuje zajedno s lijekom REZOLSTA, kako bi se informirali o metabolizmu lijeka, putovima interakcije, potencijalnim rizicima i specifičnim aktivnostima koje treba poduzeti s obzirom na istodobnu primjenu.
English: Increased AST/ALT monitoring should be considered in patients with underlying chronic hepatitis, cirrhosis, or in patients who have pre-treatment elevations of transaminases, especially during the first several months of REZOLSTA treatment.
Croatian: Mora se razmotriti pojačano praćenje AST/ALT kod bolesnika s podležećim kroničnim hepatitisom, cirozom ili kod bolesnika koji su prije liječenja imali povišene vrijednosti transaminaza, posebno tijekom prvih nekoliko mjeseci liječenja lijekom REZOLSTA.
English: Rare drug reaction with eosinophilia and systemic symptoms*
Croatian: urtikarija rijetko reakcija na lijek s eozinofilijom i sistemskim simptomima*
English: Based on the different elimination pathways of the other NRTIs (i.e. emtricitabine, lamivudine, stavudine and zidovudine) that are primarily renally excreted, and abacavir for which metabolism is not mediated by CYP, no interactions are expected for these medicinal compounds and REZOLSTA.
Croatian: Na temelju različitih puteva eliminacije drugih NRTI-ova, (tj. emtricitabina, lamivudina, stavudina i zidovudina) koji se primarno izlučuju putem bubrega, te abakavira čiji metabolizam nije posredovan CYP-om, ne očekuju se interakcije ovih lijekova i lijeka REZOLSTA.
English: Darunavir, cobicistat, or the combination of both have not been studied in patients receiving dialysis, and therefore no recommendation can be made for these patients (see section 5.2).
Croatian: Darunavir, kobicistat ili kombinacija navedenih nisu bili ispitivani u bolesnika koji su na dijalizi i stoga se ne mogu dati preporuke za te bolesnike (vidjeti dio 5.2).
English: HEPATITIS C VIRUS (HCV) DIRECT-ACTING ANTIVIRALS NS3-4A inhibitors
Croatian: ANTIVIRUSNI LIJEKOVI DIREKTNOG DJELOVANJA NA VIRUS HEPATITISA C (HCV) NS3-4A inhibitori
English: In the table below it is specified when recommendations for REZOLSTA differ from those for darunavir boosted with low dose ritonavir.
Croatian: U tablici ispod specifično je navedeno kada se preporuke za lijek REZOLSTA razlikuju od onih za darunavir pojačan s niskom dozom ritonavira.
English: C-darunavir with ritonavir dose, approximately 79.5% and 13.9% of the administered dose of
Croatian: C-darunavira s ritonavirom, približno 79,5% odnosno 13,9%
English: Interaction not studied with any of the components of REZOLSTA.
Croatian: Nije ispitana interakcija niti s jednom komponentom lijeka REZOLSTA.
English: - Take your other HIV medicines used in combination with REZOLSTA as recommended by your doctor.
Croatian: - Ostale lijekove protiv HIV-a koje primjenjujete u kombinaciji s lijekom REZOLSTA uzimajte prema preporuci Vašeg liječnika.
English: Treatment with REZOLSTA during pregnancy results in low darunavir exposure.
Croatian: Liječenje lijekom REZOLSTA tijekom trudnoće rezultira niskom izloženošću darunaviru.
English: DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) and Stevens-Johnson syndrome has been rarely (< 0.1%) reported, and during post-marketing experience toxic epidermal necrolysis and acute generalised exanthematous pustulosis have been reported.
Croatian: DRESS (osip izazvan lijekom s eozinofilijom i sistemskim simptomima) i Stevens-Johnsonov sindrom bili su rijetko (< 0,1%) prijavljivani, a tijekom postmarketinškog iskustva prijavljene su toksična epidermalna nekroliza i akutna generalizirana egzantematozna pustuloza.
English: These decreases in eGFRCG were reversible after cobicistat was discontinued and did not affect the actual glomerular filtration rate, as determined by the clearance of probe drug iohexol.
Croatian: Ova sniženja eGFRCG bila su reverzibilna nakon prestanka uzimanja kobicistata i nisu utjecala na stvarnu brzinu glomerularne filtracije, što je određeno klirensom probnog lijeka ioheksola.
English: The concomitant use with REZOLSTA may require to lower the dose of alfentanil and requires monitoring for risks of prolonged or delayed respiratory depression.
Croatian: Istodobna primjena s lijekom REZOLSTA može zahtijevati smanjenje doze alfentanila i zahtijeva praćenje rizika produljene ili odgođene respiratorne depresije.