FrancophonIA/ELRC3.0 huggingface dataset:
English: Severe and unpredictable interactions with MAOIs, involving the potentiation of opiate effects or the potentiation of serotoninergic effects, have been reported.
Slovenian: Poročani so bili primeri hudih in nepredvidljivih interakcij z zaviralci MAO, vključno s povečanimi opioidnimi ali serotoninergičnimi učinki.
English: DUROGESIC is for transdermal use.
Slovenian: Zdravilo DUROGESIC je za transdermalno uporabo.
English: Moreover, because fentanyl passes through the placenta, the use of DUROGESIC during childbirth might result in respiratory depression in the newborn infant.
Slovenian: Ker fentanil prehaja skozi placento, bi uporaba zdravila DUROGESIC med porodom lahko povzročila depresijo dihanja pri novorojencu.
English: This delay is due to the gradual increase in serum fentanyl concentration in the 24 hours following initial patch application.
Slovenian: Razlog je v postopnem večanju koncentracije fentanila v prvih 24-ih urah po prvi aplikaciji obliža.
English: Some patients may experience significant respiratory depression with DUROGESIC; patients must be observed for these effects.
Slovenian: Pri nekaterih bolnikih se med uporabo zdravila DUROGESIC lahko pojavi resna depresija dihanja, zato je treba bolnike skrbno spremljati.
English: Severe respiratory depression.
Slovenian: Huda depresija dihanja.
English: • Some antibiotics used to treat infection (such as erythromycin or clarithromycin).
Slovenian: • Nekatere antibiotike za zdravljenje okužb (kot sta eritromicin ali klaritromicin).
English: DUROGESIC and associated names (see Annex I) 12 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 25 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 50 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 75 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 100 micrograms/hour transdermal patch
Slovenian: DUROGESIC in povezana imena (glejte Prilogo I ) 12 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 25 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 50 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 75 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 100 mikrogramov/h transdermalni obliž
English: DUROGESIC should not be used during childbirth as the medication can affect the breathing of the newborn child.
Slovenian: Zdravila DUROGESIC ne smete uporabljati med porodom, saj lahko vpliva na dihanje novorojenčka.
English: {Name and address} <{tel}> <{fax}> <{e-mail}> <This medicinal product is authorised in the Member States of the EEA under the following names:> <{Name of the Member State}> <{Name of the medicinal product}> <{Name of the Member State}> <{Name of the medicinal product}> [See Annex I - To be completed nationally]
Slovenian: To zdravilo je odobreno v državah članicah EGP pod naslednjimi imeni:
English: If discontinuation of DUROGESIC is necessary, replacement with other opioids should be gradual, starting at a low dose and increasing slowly.
Slovenian: Če je potrebno zdravljenje z zdravilom DUROGESIC prekiniti, mora biti nadomeščanje z drugimi opioidi postopno; začnemo z majhnimi odmerki, ki jih postopno povečujemo.
English: The safety of DUROGESIC was evaluated in 3 open-label studies in 289 paediatric subjects with chronic pain, aged 2 to 17 years, inclusive.
Slovenian: Varnost zdravila DUROGESIC so ocenili v 3 odprtih študijah pri 289 pediatričnih preiskovancih s kroničnimi bolečinami, starih od 2 do 17 let.
English: Following DUROGESIC application, the skin under the system absorbs fentanyl, and a depot of fentanyl concentrates in the upper skin layers.
Slovenian: Po namestitvi zdravila DUROGESIC koža pod njim absorbira fentanil in depo fentanila je koncentriran v zgornjih plasteh kože.
English: Central nervous system depressants may increase the respiratory depression (see section 4.5).
Slovenian: Zdravila z delovanjem na osrednje živčevje lahko poslabšajo depresijo dihanja (glejte poglavje 4.5).
English: • The following table shows you when to change your patch:
Slovenian: • Spodnja preglednica vam prikazuje na kateri dan v tednu morate obliž zamenjati:
English: Adjustment of the individual fentanyl dose must be based on the patient's response and level of tolerance.
Slovenian: Prilagajanje odmerka fentanila pri vsakem posameznem bolniku mora temljiti na njegovem odzivu in stopnji tolerance.
English: In young children, the upper back is the preferred location to minimize the potential of the child removing the patch.
Slovenian: Pri majhnih otrocih se priporoča aplikacija na zgornji del hrbta, da kar se da zmanjšamo možnost, da si otrok sam odstrani obliž.
English: The major metabolite, norfentanyl, and other metabolites are inactive.
Slovenian: Glavni presnovek norfentanil in ostali presnovki niso aktivni.
English: What DUROGESIC is and what it is used for What you need to know before you use DUROGESIC How to use DUROGESIC
Slovenian: Kaj je zdravilo DUROGESIC in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo DUROGESIC Kako uporabljati zdravilo DUROGESIC
English: 0.23b diamorphine oral parenteral
Slovenian: 0,23b diamorfin peroralna parenteralna
English: cyproheptadine, diphenhydramine, or hydroxyzine).
Slovenian: ciproheptadin, difenhidramin ali hidroksizin).
English: Fentanyl
Slovenian: fentanil
English: There was no indication of teratogenic effects in studies in two species (rats and rabbits).
Slovenian: V študijah na dveh živalskih vrstah (podgane in kunci) ni bilo nobenih znakov teratogenih učinkov.
English: If paralytic ileus is present or suspected, treatment with DUROGESIC should be stopped.
Slovenian: Če je prisoten paralitični ileus ali sum nanj, je potrebno zdravljenje z zdravilom DUROGESIC prekiniti.
English: Monoamine Oxidase Inhibitors (MAOI)
Slovenian: Zaviralci monoaminooksidaze (zaviralci MAO)
English: Use of DUROGESIC during childbirth is not recommended because it should not be used in the management of acute or postoperative pain (see section 4.3).
Slovenian: Uporaba zdravila DUROGESIC med porodom ni priporočljiva, ker se fentanil ne sme uporabljati za lajšanje akutnih ali pooperativnih bolečin (glejte poglavje 4.3).
English: The potential for serious or life-threatening hypoventilation exists regardless of the dose of DUROGESIC transdermal system administered.
Slovenian: Obstaja možnost pojava resne ali življenjsko nevarne hipoventilacije, neodvisno od odmerka zdravila DUROGESIC.
English: Eczema, Dermatitis allergic, Skin disorder,
Slovenian: eritem ekcem, alergijski dermatitis, bolezni kože, dermatitis, kontaktni dermatitis
English: The patch should be used only on the skin of the person for whom it has been prescribed.
Slovenian: Prenos obliža na drugo osebo Obliž je namenjen samo uporabi na koži bolnika, kateremu je zdravilo predpisal zdravnik.
English: The dose should be titrated individually on the basis of average daily use of supplemental analgesics, until a balance between analgesic efficacy and tolerability is attained.
Slovenian: Odmerek je treba prilagajati individualno in upoštevati povprečni dnevni odmerek dodatnega analgetičnega zdravljenja, dokler ne dosežemo ravnovesja med analgetično učinkovitostjo in prenašanjem zdravila.
English: Of these 110 subjects, 23 (20.9%) had previously been receiving <30 mg of oral morphine equivalents per day, 66 (60.0%) had been receiving 30 to 44 mg of oral morphine equivalents per day, and 12 (10.9%) had been receiving at least 45 mg of oral morphine equivalents per day (data not available for 9 [8.2%] subjects).
Slovenian: Od teh 110 bolnikov jih je 23 (20,9 %) predhodno prejemalo odmerek opioida, ki ustreza < 30 mg peroralnega morfina na dan, 66 (60 %) jih je prejemalo odmerek opioida, ki ustreza 30 do 40 mg peroralnega morfina na dan in 12 (10,9 %) jih je prejemalo odmerek opioida, ki ustreza najmanj 45 mg peroralnega morfina na dan (za 9 [8,2 %] preiskovancev pa ni dostopnih podatkov).
English: Central Nervous System conditions including increased intracranial pressure DUROGESIC should be used with caution in patients who may be particularly susceptible to the intracranial effects of CO2 retention such as those with evidence of increased intracranial pressure, impaired consciousness, or coma.
Slovenian: Zdravilo DUROGESIC je treba uporabljati previdno pri bolnikih, ki so lahko posebej dovzetni za intrakranialne učinke zadrževanja CO2, npr. pri bolnikih z zvišanim intrakranialnim tlakom, motnjami zavesti ali komo.
English: Pharmacokinetic/Pharmacodynamic Relationships
Slovenian: Farmakokinetično/farmakodinamično razmerje
English: Your doctor will be able to tell you how long you can expect to use the patches
Slovenian: kako dolgo lahko pričakujete, da boste uporabljali obliže.
English: Initial evaluation of the maximum analgesic effect of DUROGESIC cannot be made before the patch is worn for 24 hours.
Slovenian: Maksimalnega analgetičnega učinka zdravila DUROGESIC ne moremo ovrednotiti, dokler bolnik ne nosi obliža 24 ur.
English: To prevent overdose it is recommended that opioid-naïve patients receive low doses of immediate-release opioids (eg, morphine, hydromorphone, oxycodone, tramadol, and codeine) that are to be titrated until an analgesic dosage equivalent to DUROGESIC with a release rate of 12 mcg/h or 25 mcg/h is attained.
Slovenian: Da bi preprečili preveliko odmerjanje, je pri bolnikih, ki še niso prejemali opioidov, priporočljivo titrirati odmerek z majhnimi odmerki opioidov s takojšnjim sproščanjem (npr. morfin, hidromorfon, oksikodon, tramadol in kodein), dokler ne dosežemo ekvianalgetičnega odmerka za zdravilo DUROGESIC s stopnjo sproščanja 12 mikrogramov/h ali 25 mikrogramov/h.
English: Opioids increase the tone and decrease the propulsive contractions of the smooth muscle of the gastrointestinal tract.
Slovenian: Opioidi povečajo tonus in zmanjšajo propulzivna krčenja gladkega mišičja v prebavilih.
English: Hypoaesthesia, Convulsion (including clonic convulsions and grand mal convulsion), Amnesia, Depressed level of consciousness, Loss of consciousness
Slovenian: (vključno z kloničnimi in konvulzijami grand mal), amnezija, zmanjšana stopnja zavesti, izguba zavesti
English: In general, the discontinuation of opioid analgesia should be gradual in order to prevent withdrawal symptoms (see section 4.8).
Slovenian: Splošno velja, da mora biti za preprečitev pojava odtegnitvenih simptomov ukinitev opioidne analgezije postopna (glejte poglavje 4.8).
English: Previous analgesic therapy should therefore be gradually phased out after the initial dose application until analgesic efficacy with DUROGESIC is attained.
Slovenian: Predhodno analgetično terapijo zato ukinjamo postopno, v času od prve uporabe obliža do doseženega analgetičnega učinka z zdravilom DUROGESIC.
English: • Heart beat feels fast or uneven (palpitations, tachycardia)
Slovenian: • hiter ali nenormalen srčni utrip (palpitacije, tahikardija)
English: The simulations suggest that the steady-state AUC of patients with Child-Pugh Grade B liver disease (Child-Pugh Score = 8) would be approximately 1.36 times larger compared with that of patients with normal liver function (Grade A; Child-Pugh Score = 5.5).
Slovenian: Simulacije kažejo, da bi bila AUC bolnikov z okvaro jeter Child-Pugh razreda B (stopnja Child-Pugh = 8) v stanju dinamičnega ravnovesja približno 1,36-krat večja v primerjavi z bolniki z normalnim delovanjem jeter (razred A,
English: It is recommended that DUROGESIC be used in patients who have demonstrated opioid tolerance.
Slovenian: Priporočljivo je, da zdravilo DUROGESIC uporabljajo bolniki, ki so že razvili toleranco na opioide.
English: • It may take some time for your first patch to have its maximum effect.
Slovenian: • Da začne vaš prvi obliž v celoti delovati, lahko traja nekaj časa.
English: The effects of the inducer decline gradually and may result in increased fentanyl plasma concentrations, which could increase or prolong both the therapeutic and adverse effects, and may cause serious respiratory depression.
Slovenian: Učinki induktorja postopoma upadajo in lahko povzročijo zvečanje plazemskih koncentracij fentanila, to pa lahko poveča ali podaljša terapevtski učinek in neželene učinke ter povzroči hudo depresijo dihanja.
English: DUROGESIC may interact with these medicines and you may experience changes to mental status such as feeling agitated, seeing, feeling, hearing, or smelling things that are not there (hallucinations) and other effects such as changing blood pressure, fast heart beat, high body temperature, overactive reflexes, lack of coordination, muscle stiffness, nausea, vomitting and diarrhoea.
Slovenian: Zaradi možnega mesdebojnega delovanja zdravila DUROGESIC in temi zdravili lahko pri vas pride do sprememb duševnega stanja, kot so vznemirjenost, videnje, čutenje, slišanje ali vohanje stvari, ki jih ni (halucinacije) in drugih učinkov, kot so sprememba krvnega tlaka, hiter srčni utrip, visoka telesna temperatura, pretirane refleksne reakcije, pomanjkanje koordinacije, okorelost mišic, slabost, bruhanje in driska.
English: Data in subjects with cirrhosis and simulated data in subjects with different grades of impaired liver function treated with transdermal fentanyl suggest that fentanyl concentrations may be increased, and fentanyl clearance may be decreased compared to subjects with normal liver function.
Slovenian: Podatki o bolnikih s cirozo in simulirani podatki pri preiskovancih z različnimi stopnjami okvare jeter, zdravljenih s transdermalnim fentanilom, kažejo, da so lahko koncentracije fentanila zvečane, očistek fentanila pa zmanjšan v primerjavi s preiskovanci z normalnim delovanjem jeter.
English: The appropriate initiating dose of DUROGESIC should be based on the patient's current opioid use.
Slovenian: Primeren začetni odmerek zdravila DUROGESIC mora biti določen na podlagi trenutne uporabe opioidov pri bolniku.
English: Caution is advised when DUROGESIC is co-administered with medicinal products that affect the serotonergic neurotransmitter systems.
Slovenian: Pri predpisovanju zdravila DUROGESIC sočasno z zdravili, ki vplivajo na serotoninergični nevrotransmiterski sistem, je potrebna previdnost.
English: • Unusual feeling in the skin, such as tingling or crawling feelings (paraesthesia)
Slovenian: • nenavaden občutek na koži kot je mravljinčenje ali zbadanje (parestezija)
English: Respiratory depression may persist beyond the removal of the DUROGESIC patch.
Slovenian: Depresija dihanja lahko traja še po odstranitvi transdermalnega obliža DUROGESIC.
English: • Do not use soap or any other cleansers, creams, moisturisers, oils or talc before applying the patch
Slovenian: • Pred namestitvijo obliža ne uporabljajte mil ali drugih čistilnih sredstev, krem, losijonov, olj ali smukca.
English: DUROGESIC should be applied to non-irritated and non-irradiated skin on a flat surface of the torso or upper arms.
Slovenian: Transdermalni obliž DUROGESIC je treba prilepiti na nerazdraženo in neobsevano kožo, na ravno površino zgornjega dela trupa ali nadlakti.
English: Fentanyl is an opioid analgesic, interacting predominantly with the µ opioid receptor.
Slovenian: Mehanizem delovanja Fentanil je opioidni analgetik, ki se veže predvsem na µ-opioidne receptorje.
English: How to store DUROGESIC Contents of the pack and other information
Slovenian: Shranjevanje zdravila DUROGESIC Vsebina pakiranja in dodatne informacije
English: Stopping suddenly may make you feel unwell
Slovenian: Če jih boste nenadoma prenehali uporabljati, se boste morda počutili slabo.
English: The safety profile in children and adolescents treated with DUROGESIC was similar to that observed in adults.
Slovenian: Varnostni profil neželenih učinkov je bil pri otrocih in mladostnikih, ki so prejemali zdravilo DUROGESIC, podoben kot pri odraslih.
English: • Medicines used to treat HIV infection (such as ritonavir).
Slovenian: • Zdravila za zdravljenje okužbe z virusom HIV (kot je ritonavir).
English: If you switch from a different painkiller to DUROGESIC or if you suddenly stop using DUROGESIC, you may notice withdrawal effects such as sickness, feeling sick, diarrhoea, anxiety or shivering.
Slovenian: Če boste prešli z drugega protibolečinskega zdravila na zdravilo DUROGESIC ali če nenadoma prenehate uporabljati zdravilo DUROGESIC, boste morda opazili odtegnitvene učinke zdravila, kot so slabost, bruhanje, driska, občutek tesnobe in drgetanje.
English: Make sure it sticks well, especially the edges
Slovenian: Prepričajte se, da se je obliž dobro prilepil na kožo, zlasti na robovih.
English: • Itching, skin rash or redness of the skin
Slovenian: • srbenje, kožni izpuščaj ali pordela koža
English: The concomitant use of CYP3A4 inhibitors and DUROGESIC is not recommended, unless the patient is closely monitored (see section 4.4).
Slovenian: Sočasna uporaba zaviralcev CYP3A4 in zdravila DUROGESIC ni priporočljiva, razen če je bolnik pod skrbnim nadzorom (glejte poglavje 4.4).
English: • If you forget, change your patch as soon as you remember and make note of the day and time.
Slovenian: Če ste pozabili zamenjati obliž • Če ste pozabili zamenjati obliž, ga zamenjajte takoj, ko se spomnite in si zabeležite dan in čas.
English: The dosage may subsequently be titrated upwards or downwards, if required, in increments of either 12 or 25 mcg/h to achieve the lowest appropriate dosage of DUROGESIC depending on response and supplementary analgesic requirements.
Slovenian: ZMANJŠAMO, ČE JE POTREBNO, V ODMERKIH PO 12 ALI 25 MIKROGRAMOV/H, DOKLER NE DOSEŽEMO NAJMANJŠEGA PRIMERNEGA ODMERKA ZDRAVILA DUROGESIC, ODVISNO OD BOLNIKOVEGA ODZIVA IN DODATNIH POTREB PO ANALGETIKU.
English: If the site of DUROGESIC application requires cleansing prior to application of the patch, this should be done with clear water.
Slovenian: Če je treba kožo pred uporabo zdravila DUROGESIC očistiti, to naredimo s čisto vodo.
English: • Your upper body or arm
Slovenian: • zgornji del telesa ali rame
English: DUROGESIC should be administered to only those opioid-tolerant paediatric patients (ages 2 to 16 years) who are already receiving at least 30 mg oral morphine equivalents per day.
Slovenian: Zdravilo DUROGESIC se sme uporabiti samo pri pediatričnih bolnikih (starih od 2 do 16 let), ki dobro prenašajo opioide in že prejemajo odmerek opioida, ki ustreza vsaj 30 mg peroralnega morfina/dan.
English: High inter-subject variability in plasma concentrations has been observed.
Slovenian: Opažali so velike razlike v plazemskih koncentracijah med posamezniki.
English: DUROGESIC should be used with caution in patients with brain tumours.
Slovenian: Zdravilo DUROGESIC je treba previdno uporabljati tudi pri bolnikih z možganskimi tumorji.
English: DUROGESIC should not be used during pregnancy unless you have discussed this with your doctor.
Slovenian: Zdravila DUROGESIC ne smete uporabljati med nosečnostjo, razen če ste se o tem pogovorili z zdravnikom.
English: Therefore, the concomitant use of DUROGESIC and CYP3A4 inhibitors is not recommended unless the benefits outweigh the increased risk of adverse effects.
Slovenian: Sočasna uporaba zdravila DUROGESIC in zaviralcev CYP3A4 ni priporočljiva, razen kadar koristi odtehtajo zvečano tveganje za pojav neželenih učinkov.
English: Dose titration and maintenance therapy The DUROGESIC patch should be replaced every 72 hours.
Slovenian: Titracija odmerka in vzdrževalno zdravljenje Transdermalni obliž DUROGESIC je treba zamenjati vsakih 72 ur.
English: The potential for serious or life-threatening hypoventilation exists even if the lowest dose of DUROGESIC is used in initiating therapy in opioid-naïve patients, especially in elderly or patients with hepatic or renal impairment.
Slovenian: Verjetnost za pojav resne ali življenjsko nevarne hipoventilacije obstaja celo pri pri uvajanju zdravila DUROGESIC v najmanjšem odmerku bolnikom, ki še niso jemali opioidov, še posebej starejšim bolnikom in bolnikom z okvaro jeter ali ledvic.
English: To remove the patch from the protective sachet, locate the pre-cut notch (indicated by an arrow on the patch label) along the edge of the seal.
Slovenian: Za odpiranje vrečice poiščemo zarezo na robu blazinice (označena je s puščico).
English: 1a parenteral buprenorphine sublingual parenteral codeine oral parenteral
Slovenian: 1a parenteralna buprenorfin sublingvalna parenteralna kodein peroralna parenteralna
English: • Let your doctor know this has happened and leave the patch on for another 3 days (72 hours) or as directed by your doctor, before changing the new patch as usual
Slovenian: • Obvestite svojega zdravnika in obliž ponovno zamenjajte po 3 dneh (72 urah) ali kot vam je naročil vaš zdravnik.
English: A patch accidently sticking to another person (particularly a child) can cause the medicine in the patch to go through the skin of the other person and cause serious side effects such as breathing difficulties, with slow or shallow breathing which may be fatal.
Slovenian: Če se obliž prilepi na drugo osebo (predvsem na otroka), lahko pride do nenamernega vnosa zdravila in do neželenih učinkov, kot so težave z dihanjem (počasno ali plitvo dihanje), ki lahko povzročijo smrt.
English: You may need to be closely monitored if you are taking some of the types of medicines listed below or if you stop taking some of the types of medicines listed below, as this may affect the strength of DUROGESIC you need.
Slovenian: Če jemljete katero od spodaj naštetih zdravil ali ste katero od njih prenehali jemati, vas bodo morda morali skrbno spremljati, ker lahko vplivajo na jakost zdravila DUROGESIC, ki jo potrebujete.
English: A patient who is treated with DUROGESIC should wait at least 1 week after removal of the last patch before initiating treatment with a CYP3A4 inhibitor.
Slovenian: DUROGESIC, mora po odstranitvi zadnjega obliža počakati vsaj 1 teden, preden lahko začne zdravljenje z zaviralcem CYP3A4.
English: Serotonergic medicinal products
Slovenian: Serotoninergična zdravila
English: Further open the sachet along both sides, folding the sachet open like a book.
Slovenian: Vrečico odpremo kot knjigo po obeh straneh zavarjenega roba.
English: In two paediatric studies, the required fentanyl transdermal patch dose was calculated conservatively: 30 mg to 44 mg oral morphine per day or its equivalent opioid dose was replaced by one DUROGESIC 12 mcg/h patch.
Slovenian: V dveh pediatričnih študijah je bil ustrezen odmerek transdermalnih obližev s fentanilom preračunan previdno: 30 do 44 mg peroralnega morfina na dan ali enakovreden odmerek opioida so zamenjali z enim transdermalnim obližem DUROGESIC 12,5 mikrogramov/h.
English: • Feeling of body temperature change
Slovenian: • spremembe telesne telesne temperature
English: 15b methadone oral parenteral
Slovenian: 15b metadon peroralna parenteralna
English: To calculate the appropriate starting dose of DUROGESIC, follow the steps below.
Slovenian: Pri izračunu primernega odmerka zdravila DUROGESIC upoštevajte naslednje korake: 1.
English: Oral doses are those recommended when changing from a parenteral to an oral route.
Slovenian: Peroralni odmerki so tisti priporočeni, pri zamenjavi parenteralnega s peroralnim načinom zdravljenja.
English: Very rarely these breathing problems can be life-threatening or even fatal, especially in people who have not used strong opioid painkillers (like DUROGESIC or morphine) before.
Slovenian: Zelo redko so lahko te težave z dihanjem življenjsko nevarne ali celo smrtne, še posebej pri bolnikih, ki še niso uporabljali močnih opioidnih protibolečinskih zdravil (kot je zdravilo
English: If serotonin syndrome is suspected, treatment with DUROGESIC should be discontinued.
Slovenian: Če obstaja sum za serotoninski sindrom, je potrebno zdravljenje z zdravilom DUROGESIC prekiniti.
English: Hair at the application site (a non-hairy area is preferable) should be clipped (not shaved) prior to application.
Slovenian: Pred aplikacijo obliža je treba dlake na mestu aplikacije (po možnosti je treba izbrati del kože, kjer ni dlak) porezati (ne obriti).
English: Extra caution should be used in patients with chronic constipation.
Slovenian: Posebna pozornost je potrebna pri bolnikih s kroničnim zaprtjem.
English: • Muscle tremors or spasms
Slovenian: • tresenje ali mišični krči