FrancophonIA/ELRC3.0 huggingface dataset:
English: If you develop or are likely to develop cancers of the blood, you should not use Pelgraz, unless instructed by your doctor.
Croatian: Ukoliko imate ili postoji neposredna opasnost od razvoja oblika raka krvi, ne biste trebali primjenjivati Pelgraz, osim u slučaju da je to savjet Vašeg liječnika.
English: You do not have to remove the air bubble before injecting.
Croatian: Ne morate uklanjati mjehurić zraka prije ubrizgavanja injekcije.
English: The marketing authorisation holder (MAH) shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the marketing authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će dodatne farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom Planu upravljanja rizikom, (RMP), koji se nalazi u Modulu 1.8.2
English: Inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) has been reported rarely in cancer patients and healthy donors.
Croatian: Upala aorte (velike krvne žile koja prenosi krv iz srca u tijelo) rijetko je zabilježena u bolesnika s rakom i zdravih darivatelja.
English: Do not remove the needle cover from the syringe until just before you are ready to inject.
Croatian: Nemojte skidati pokrov s igle sve dok ne budete spremni za primjenu injekcije.
English: The safety and efficacy of pegfilgrastim administration in de novo AML patients aged < 55 years with cytogenetics t(15;17) have not been established.
Croatian: Sigurnost i djelotvornost primjene pegfilgrastima u bolesnika s de novo AML-om mlađih od 55 godina s citogenetskim nalazom t(15;17) nisu utvrđeni.
English: In the absence of growth factor support, this regimen has been reported to result in a mean duration of grade 4 neutropenia of 5 to7 days, and a 30-40% incidence of febrile neutropenia.
Croatian: Bez potpore faktorom rasta primijećeno je da takav režim rezultira srednjim trajanjem neutropenije 4. stupnja od 5 do 7 dana te incidenciju pojave febrilne neutropenije od 30 do 40 %.
English: Find a comfortable, well-lit place and put everything you need where you can reach them (the pre-filled injector and alcohol swab).
Croatian: Pronađite udobno, dobro osvijetljeno mjesto i stavite sve što trebate tako da Vam je pri ruci (napunjeni injektor i jastučić natopljen alkoholom).
English: Ask your doctor or pharmacist for advice before taking any medicine.
Croatian: Obratite se liječniku ili ljekarniku za savjet prije uzimanja bilo kojih lijekova.
English: Limited data indicate that the pharmacokinetics of pegfilgrastim in elderly subjects (> 65 years) is similar to that in adults.
Croatian: Ograničeni podaci ukazuju da je farmakokinetika pegfilgrastima u starijih ispitanika (> 65 godina)
English: The adverse reactions were similar to those in subjects receiving lower doses of pegfilgrastim.
Croatian: Nuspojave su bile slične onima koje se javljaju kod nižih doza pegfilgrastima.
English: Such elevation in WBCs is transient, typically seen 24 to 48 hours after administration and is consistent with the pharmacodynamic effects of this medicinal product.
Croatian: Takav je porast broja leukocita prolazan, tipično se uočava od 24 do 48 sati nakon primjene lijeka i u skladu je s farmakodinamičkim učincima ovog lijeka.
English: Do not dispose of injector in household trash.
Croatian: Nemojte bacati injektor u kućni otpad.
English: The needle cover of the pre-filled syringe contains dry natural rubber (a derivative of latex), which may cause allergic reactions.
Croatian: Pokrov igle napunjene štrcaljke sadrži suhu prirodnu gumu (derivat lateksa), koja može uzrokovati alergijske reakcije.
English: Pelgraz left at room temperature for more than 72 hours should be discarded.
Croatian: Pelgraz ostavljen na sobnoj temperaturi dulje od 72 sata se mora ukloniti.
English: • Stevens-Johnson syndrome, which can appear as reddish target-like or circular patches often with central blisters on the trunk, skin peeling, ulcers of mouth, throat, nose, genitals and eyes and can be preceded by fever and flu-like symptoms.
Croatian: • Stevens Johnsonov sindrom, koji se može pojaviti kao crvenkaste mrlje u obliku mete ili kružne mrlje često sa središnjim mjehurićima na trupu, ljuštenje kože, vrijedovi u ustima, grlu, nosu, na genitalijama i očima, čemu može prethoditi vrućica i simptomi nalik gripi.
English: • have sudden signs of allergy such as rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing these could be signs of a severe allergic reaction.
Croatian: • primijetite iznenadne znakove alergije kao što su osip, svrbež ili koprivnjača na koži, oticanje lica, usana, jezika ili drugih dijelova tijela, nedostatak zraka, piskanje ili otežano disanje, to bi mogli biti znakovi teške alergijske reakcije.
English: In most cases aortitis was diagnosed by CT scan and generally resolved after withdrawal of filgrastim or pegfilgrastim.
Croatian: U većini slučajeva aortitis je dijagnosticiran CT snimkom i obično se povlačio nakon prekida primjene filgrastima ili pegfilgrastima.
English: - The active substance is pegfilgrastim.
Croatian: - Djelatna tvar je pegfilgrastim.
English: • inflammation of the aorta (the large blood vessel which transports blood from the heart to the body), see section 2.
Croatian: • upala aorte (velike krvne žile koja prenosi krv iz srca u tijelo), vidjeti dio 2.
English: Accidental exposure to freezing temperatures for a single period of less than 24 hours does not adversely affect the stability of Pelgraz.
Croatian: Slučajno jednokratno izlaganje temperaturama zamrzavanja u razdoblju kraćem od 24 sata ne utječe nepovoljno na stabilnost Pelgraza.
English: Your doctor has given you Pelgraz to encourage your bone marrow (part of the bone which makes blood cells) to produce more white blood cells that help your body fight infection.
Croatian: Liječnik Vam je propisao lijek Pelgraz za poticanje funkcije koštane srži (dio kosti koji stvara krvne stanice) kako bi stvorila više bijelih krvnih stanica za borbu tijela protiv infekcija.
English: • abnormal blood test results (lactate dehydrogenase, uric acid and alkaline phosphatase).
Croatian: • abnormalni rezultati krvnih pretraga (laktat dehidrogenaza, mokraćna kiselina i alkalna fosfataza).
English: While maintaining pressure on the plunger, remove the syringe from the patient.
Croatian: Zadržavajući pritisak na klipu, izvucite štrcaljku iz kože bolesnika.
English: If you have any problems, please ask your doctor or nurse for help and advice.
Croatian: Ako imate bilo kakvih problema, obratite se liječniku ili medicinskoj sestri za pomoć i savjet.
English: Keep hands away from needle guard after cap is removed.
Croatian: Ruke držite dalje od štitnika za iglu nakon što skinete poklopac.
English: Pelgraz does not contain any preservative.
Croatian: Pelgraz ne sadrži konzervanse.
English: Severe skin reactions (Stevens-Johnson syndrome) have been reported with the use of Pelgraz .
Croatian: Prijavljene su teške kožne reakcije (Stevens Johnsonov sindrom) povezane s primjenom lijeka Pelgraz.
English: Pegfilgrastim did not affect reproductive performance or fertility in male or female rats at cumulative weekly doses approximately 6 to 9 times higher than the recommended human dose (based on body surface area) (see section 5.3).
Croatian: Plodnost Pegfilgastrim nije utjecao na sposobnost reprodukcije ili plodnost mužjaka i ženki štakora nakon što su dobivali tjedne kumulativne doze, otprilike 6 do 9 puta više od doza preporučenih za ljude (procjena temeljem površine tijela) (vidjeti dio 5.3).
English: In clinical trials, pegfilgrastim has been safely administered 14 days before chemotherapy.
Croatian: kliničkim se ispitivanjima pegfilgrastim sigurno primjenjivao 14 dana prije kemoterapije.
English: Your doctor will check your blood and urine regularly as Pelgraz can harm the tiny filters inside your kidneys (glomerulonephritis).
Croatian: Vaš će liječnik redovito provjeravati Vašu krv i mokraću jer Pelgraz može oštetiti sitne filtere unutar
English: The needle cover of the pre-filled syringe contains dry natural rubber (see section 4.4).
Croatian: Pokrov igle napunjene štrcaljke sadrži suhu prirodnu gumu (vidjeti dio 4.4).
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: • prilikom svake izmjene sustava upravljanja rizicima, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik,
English: Uncommon (≥ 1/1,000 to
Croatian: Rijetko (≥ 1/10 000 do
English: The needle safety guard covers the needle after injection to prevent needle stick injury.
Croatian: Sigurnosni štitnik za iglu prekriva iglu nakon injiciranja kako bi se spriječila ozljeda ubodom igle.
English: Do not inject if you drop the pre-filled injector after removing cap.
Croatian: Nemojte ubrizgavati injekciju ako Vam napunjeni injektor ispadne nakon što skinete poklopac
English: There were no adverse effects observed in offspring from pregnant rats given pegfilgrastim subcutaneously, but in rabbits pegfilgrastim has been shown to cause embryo/foetal toxicity (embryo loss) at cumulative doses approximately 4 times the recommended human dose, which were not seen when pregnant rabbits were exposed to the recommended human dose.
Croatian: U potomstvu skotnih štakora kojima je supkutano primijenjen pegfilgrastim nisu primijećene nuspojave, ali se pokazalo da je pegfilgrastim u zečeva uzrokovao embrionalnu/fetalnu toksičnost (gubitak embrija) pri kumulativnim dozama koje su bile oko 4 puta veće od preporučene doze za ljude, no isto se nije pokazalo kod primjene doza koje odgovaraju preporučenoj dozi za ljude.
English: • Lift straight up: The yellow band indicates that the needle guard is locked.
Croatian: • Podignite injektor pod pravim kutom: žuta traka označava da je štitnik za iglu aktiviran i zaključan.
English: The onset of pulmonary signs such as cough, fever, and dyspnoea in association with radiological signs of pulmonary infiltrates, and deterioration in pulmonary function along with increased neutrophil count may be preliminary signs of Adult Respiratory Distress Syndrome (ARDS).
Croatian: Pojava plućnih simptoma, kao što su kašalj, vrućica i dispneja, povezanih s radiološkim znacima plućnih infiltrata i pogoršanjem funkcije pluća uz povišen broj neutrofila mogu biti početni znaci sindroma respiratornog distresa u odraslih (engl. adult respiratory distress syndrome, ARDS).
English: The safety and efficacy of Pelgraz for the mobilisation of blood progenitor cells in patients or healthy donors has not been adequately evaluated.
Croatian: Sigurnost i djelotvornost Pelgraza u mobilizaciji krvotvornih matičnih stanica u bolesnika ili zdravih darivatelja nije odgovarajuće ispitana.
English: The safety and efficacy of Pelgraz in children and adolescents has not yet been established.
Croatian: Sigurnost i djelotvornost Pelgraza u djece i adolescenata nisu još ustanovljene.
English: If you stop using Pelgraz
Croatian: Ako prestanete primijenjivati Pelgraz
English: The most suitable places to inject yourself are:
Croatian: Najprikladnija mjesta za samostalnu primjenu injekcije su: • gornji dio bedara; te
English: The safety and efficacy of Pelgraz in children has not yet been established.
Croatian: Sigurnost i djelotvornost Pelgraza u djece još nije utvrđena.
English: These could be symptoms of condition called “Capillary Leak Syndrome” which causes blood to leak from the small blood vessels into your body.
Croatian: Ovo mogu biti znakovi stanja koje se zove „sindrom povećane propusnosti kapilara" koji uzrokuje izlaženje krvi iz malih krvnih žila unutar tijela.
English: Take the pre-filled syringe out of the refrigerator.
Croatian: Uzmite napunjenu štrcaljku iz hladnjaka.
English: The safety and efficacy of pegfilgrastim have not been investigated in patients with myelodysplastic syndrome, chronic myelogenous leukaemia, and in patients with secondary AML; therefore, it should not be used in such patients.
Croatian: Sigurnost i djelotvornost pegfilgrastima nije ispitivana u bolesnika s mijelodisplastičnim sindromom, kroničnom mijeloičnom leukemijom te u bolesnika sa sekundarnom AML-om, stoga se lijek ne smije primjenjivati u tih bolesnika.
English: • a pre-filled injector of Pelgraz;
Croatian: • napunjeni injektor lijeka Pelgraz;
English: Musculoskeletal pain (myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain)
Croatian: Bol u kostima Mišićno-koštana bol (mijalgija, artralgija, bol u udovima, bol u leđima, mišićno koštana bol, bol u vratu)
English: Take the pre-filled injector out of the refrigerator.
Croatian: Uzmite napunjeni injektor iz hladnjaka.
English: Splenic rupture2
Croatian: Splenomegalija2 Ruptura slezene2
English: In order to improve the traceability of biological medicinal products, the trade name of the administered product should be clearly recorded.
Croatian: Kako bi se poboljšala sljedivost bioloških lijekova, naziv primijenjenog lijeka mora se jasno evidentirati.
English: These could be symptoms of an uncommon (may affect up to 1 in 100 people) condition called “Capillary Leak Syndrome” which causes blood to leak from the small blood vessels into your body and needs urgent medical attention.
Croatian: Ovo mogu biti simptomi manje čestog (može se javiti u do 1 na 100 osoba) stanja koje se naziva „sindrom povećane propusnosti kapilara“, koji uzrokuje izlaženje krvi iz malih krvnih žila unutar tijela i zahtijeva hitnu liječničku pomoć.
English: • have recently had a serious lung infection (pneumonia), fluid in the lungs (pulmonary oedema), inflammation of the lungs (interstitial lung disease) or an abnormal chest x-ray (lung infiltration).
Croatian: • ste nedavno imali ozbiljniju infekciju pluća (upalu pluća), tekućinu u plućima (edem pluća), upalne procese u području pluća (intersticijska bolest pluća) ili neuobičajeni rendgenski nalaz pluća (plućna infiltracija);
English: Injecting the solution with the air bubble is harmless.
Croatian: Ubrizgavanje otopine koja sadrži mjehurić je bezopasno.
English: The incidence of hospitalisations and intravenous antiinfective use associated with a clinical diagnosis of febrile neutropenia was lower in the pegfilgrastim group compared with placebo (1% versus 14%, p < 0.001; and 2% versus 10%, p < 0.001).
Croatian: Incidencija bolničkog liječenja i intravenske primjene antiinfektivnih lijekova, povezanog s kliničkom dijagnozom febrilne neutropenije, bila je niža u skupini liječenoj pegfilgrastimom nego u skupini koja je primala placebo (1 % prema 14 %, p < 0,001 te 2 % prema 10 %, p < 0,001).
English: After injecting the liquid, while keeping the syringe at the same angle and maintaining pressure on the plunger, remove the needle and then let go of your skin.
Croatian: Nakon ubrizgavanja tekućine izvucite iglu držeći štrcaljku pod istim kutom i zadržavajući pritisak na klipu, a zatim pustite nabor kože.
English: Check the expiry date on the pre-filled injector label (EXP).
Croatian: Provjerite rok valjanosti na naljepnici napunjenog injektora (EXP).
English: What should I do before I give myself a subcutaneous injection of Pelgraz?
Croatian: Što morate napraviti prije nego si date potkožnu injekciju lijeka Pelgraz?
English: How do I give my injection?
Croatian: Kako primijeniti injekciju?
English: • Do not lift the injector during injection.
Croatian: • Nemojte odizati uređaj tijekom ubrizgavanja.
English: Pre-filled syringe with needle safety guard b.
Croatian: Napunjena štrcaljka sa sigurnosnim štitnikom za iglu b.
English: The safety and efficacy of Pelgraz have not been evaluated in patients receiving chemotherapy associated with delayed myelosuppression e.g. nitrosoureas.
Croatian: Sigurnost i djelotvornost Pelgraza nisu ispitivani u bolesnika koji primaju kemoterapiju povezanu s odgođenom mijelosupresijom, npr. nitrozoureju.
English: Using the pre filled syringe with a needle safety guard The needle safety guard covers the needle after injection to prevent needle stick injury.
Croatian: Uporaba napunjene štrcaljke sa sigurnosnim štitnikom za iglu Sigurnosni štitnik za iglu prekriva iglu nakon injiciranja kako bi se spriječila ozljeda ubodom igle.
English: • experience a cough, fever and difficulty breathing.
Croatian: • počnete kašljati, imate vrućicu ili otežano disanje.
English: Always keeping your skin pinched, depress the plunger slowly and evenly while grasping the finger flange until the entire dose has been given and the plunger cannot be depressed any further.
Croatian: Uvijek držite nabor kože između prstiju te polako i jednoliko potiskujte klip pritišćući prstima obod štrcaljke dok ne primijenite cijelu dozu i dok se klip ne bude mogao dalje potisnuti.
English: Do not use if expiration date has passed.
Croatian: Ne koristite lijek ako je rok valjanosti istekao.
English: Common (≥ 1/100 to
Croatian: (≥ 1/100 do
English: What Pelgraz is and what it is used for What you need to know before you use Pelgraz How to use Pelgraz
Croatian: Što je Pelgraz i za što se koristi Što morate znati prije nego počnete primjenjivati lijek Pelgraz Kako primjenjivati lijek Pelgraz Moguće nuspojave
English: Pelgraz is used to reduce the duration of neutropenia (low white blood cell count) and the occurrence of febrile neutropenia (low white blood cell count with a fever) which can be caused by the use of cytotoxic chemotherapy (medicines that destroy rapidly growing cells).
Croatian: Pelgraz se primjenjuje za smanjenje trajanja neutropenije (smanjenog broja bijelih krvnih stanica) i pojave febrilne neutropenije (smanjeni broj bijelih krvnih stanica praćen vrućicom), koji se mogu javiti uslijed primjene citotoksične kemoterapije (lijekova koji uništavaju brzorastuće stanice).
English: The youngest age group (0-5 years) had a higher mean exposure to pegfilgrastim (AUC) (± Standard Deviation) (47.9 ± 22.5 mcg·hr/ml) than older children aged 6-11 years and 12-21 years (22.0 ± 13.1 mcg·hr/mL and 29.3 ± 23.2 mcg·hr/mL, respectively) (see section 5.1).
Croatian: Djeca u najmlađoj dobnoj skupini (0 - 5 godina) imala su veću srednju ekspoziciju pegfilgrastimu (AUC) (± standardno odstupanje) (47,9 ± 22,5 μg·hr/ml) u odnosu na stariju djecu u dobi od 6 - 11, odnosno 12 - 21 godine (22,0 ± 13,1 μg·hr/ml te 29,3 ± 23,2 μg·hr/ml) (vidjeti dio 5.1).
English: • are aware of any altered blood cell counts (e.g. increase in white blood cells or anaemia) or decreased blood platelet counts, which reduces the ability of your blood to clot (thrombocytopenia).
Croatian: • imate saznanje o poremećenom broju krvnih stanica (npr. povećanje broja bijelih krvnih stanica ili anemija) ili smanjeni broj krvnih pločica koji može uzrokovati poremećaje u zgrušavanju (trombocitopenija).
English: How do I prepare my Pelgraz injection?
Croatian: Kako pripremiti injekciju lijeka Pelgraz?
English: (acute febrile dermatosis)1,2
Croatian: Sweetov sindrom (akutna febrilna dermatoza)1,2;
English: In view of the possible risk of microbial contamination, Pelgraz syringes are for single use only.
Croatian: Zbog potencijalnog rizika od mikrobiološke kontaminacije, štrcaljke s lijekom Pelgraz namijenjene su isključivo jednokratnoj uporabi.
English: Injection
Croatian: Ubrizgavanje
English: Pelgraz contains sorbitol (E420) and sodium acetate
Croatian: Pelgraz sadrži sorbitol (E420) i natrijev acetat
English: Pelgraz therapy should be initiated and supervised by physicians experienced in oncology and/or haematology.
Croatian: 4.2 Doziranje i način primjene Liječenje lijekom Pelgraz mora započeti i nadzirati liječnik s iskustvom u onkologiji i/ili hematologiji.
English: Over the entire study, the rate of febrile neutropenia was 13% of pegfilgrastim-treated patients compared with 20% of filgrastim-treated patients (difference 7%, 95% CI of -19%, 5%).
Croatian: Tijekom cijelog ispitivanja stopa febrilne neutropenije u bolesnika liječenih pegfilgrastimom iznosila je 13 %, a 20 % u bolesnika liječenih filgrastimom (razlika 7 %, 95 % CI od -19 %, 5 %).
English: The symptoms can include fever, abdominal pain, malaise, back pain and increased inflammatory markers (e.g. C-reactive protein and white blood cell count).
Croatian: Simptomi mogu uključivati vrućicu, bol u trbuhu, malaksalost, bol u leđima i povišene upalne markere (npr. C-reaktivni protein i broj bijelih krvnih stanica).
English: In a placebo-controlled, double blind study in patients with breast cancer the effect of pegfilgrastim on the incidence of febrile neutropenia was evaluated following administration of a chemotherapy regimen associated with a febrile neutropenia rate of 10-20% (docetaxel 100 mg/m2 every 3 weeks for
Croatian: U placebo kontroliranom, dvostruko slijepom ispitivanju provedenom u bolesnica s karcinomom dojke, ispitivan je učinak pegfilgrastima na incidenciju pojave febrilne neutropenije nakon primjene kemoterapijskog režima povezanog s razvojem febrilne neutropenije sa stopom od 10-20 % (docetaksel 100 mg/m2 svaka 3 tjedna tijekom 4 ciklusa).
English: Pre-filled injector containing a pre-filled syringe (type I glass) with a permanently attached stainless steel injection needle.
Croatian: Napunjeni injektor koji sadrži napunjenu štrcaljku (staklo tipa I) s fiksno pričvršćenom iglom za injekciju od nehrđajućeg čelika.
English: Pelgraz has no or negligible effect on the ability to drive or use machines.
Croatian: Pelgraz ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: • have any of the following or combination of the following side effects: - swelling or puffiness, which may be associated with passing water less frequently, difficulty breathing, abdominal swelling and feeling of fullness, and a general feeling of tiredness.
Croatian: • imate jednu od sljedećih ili kombinaciju sljedećih nuspojava: oticanje ili podbuhlost, što može biti povezano s rjeđom učestalošću mokrenja, otežano disanje, oticanje trbuha i osjećaj punoće, te opći osjećaj umora.
English: Using the pre-filled syringe with needle safety guard
Croatian: Uporaba napunjene štrcaljke sa sigurnosnim štitnikom za iglu
English: The needle cap on the pre-filled syringe contains a derivative of latex and may cause severe allergic reactions.
Croatian: Kapica na igli napunjene štrcaljke sadrži derivat lateksa koji može uzrokovati teške alergijske reakcije;
English: Limited clinical data suggest a comparable effect on time to recovery of severe neutropenia for pegfilgrastim to filgrastim in patients with de novo AML (see section 5.1).
Croatian: Akutna mijeloična leukemija (AML) Ograničeni klinički podaci upućuju na usporediv učinak pegfilgrastima i filgrastima na vrijeme potrebno za oporavak od teške neutropenije u bolesnika s de novo AML-om (vidjeti dio 5.1).
English: Concomitant use of Pelgraz with any chemotherapeutic medicinal product has not been evaluated in patients.
Croatian: Istodobna primjena Pelgraza i kemoterapijskog lijeka nije procijenjena u bolesnika.
English: Depress the plunger slowly and evenly until the entire dose has been given and the plunger cannot be depressed any further.
Croatian: Polako i jednoliko potišćite klip sve dok ne primijenite cijelu dozu i dok se klip ne može dalje potisnuti.
English: Aortitis has been reported after filgrastim or pegfilgrastim administration in healthy subjects and in cancer patients.
Croatian: Aortitis Nakon primjene filgrastima ili pegfilgrastima u zdravih ispitanika i bolesnika s rakom prijavljen je aortitis.
English: Similarly to filgrastim, neutrophils produced in response to pegfilgrastim show normal or enhanced function as demonstrated by tests of chemotactic and phagocytic function.
Croatian: Slično kao i kod filgrastima, neutrofili nastali kao odgovor na pegfilgrastim imaju normalnu ili poboljšanu funkciju,