FrancophonIA/ELRC3.0 huggingface dataset:
English: Appropriate laboratory testing should be conducted prior to initiating therapy with Symtuza and patients should be monitored during treatment.
Slovenian: Pred začetkom zdravljenja z zdravilom Symtuza je treba opraviti ustrezne laboratorijske preiskave in spremljati bolnika med zdravljenjem.
English: Any child exposed in utero to nucleoside and nucleotide analogues, even HIV negative children, should have clinical and laboratory follow-up and should be fully investigated for possible mitochondrial dysfunction in case of relevant signs or symptoms.
Slovenian: Vse otroke, ki so bili in utero izpostavljeni nukleozidnim in nukleotidnim analogom (tudi če so otroci HIV-negativni), je treba spremljati tako klinično kot laboratorijsko in jih v primeru prisotnosti ustreznih znakov in simptomov v celoti preiskati glede možne mitohondrijske disfunkcije.
English: Unchanged darunavir accounted for approximately 41.2% and 7.7% of the administered dose in faeces and urine, respectively.
Slovenian: Nespremenjeni darunavir je v blatu predstavljal približno 41,2% danega odmerka, v urinu pa 7,7%.
English: Symtuza might increase the risk of bleeding.
Slovenian: Zdravilo Symtuza lahko poveča tveganje za krvavitve.
English: Overall, 22% had baseline plasma HIV-1 RNA > 100,000 copies/mL.
Slovenian: Skupno je imelo 22% bolnikov izhodiščno vrednost HIV-1 RNA v plazmi > 100.000 kopij/ml.
English: Emtricitabine can be removed by haemodialysis, which removes approximately 30% of the emtricitabine dose over a 3 hour dialysis period starting within 1.5 hours of emtricitabine dosing.
Slovenian: Približno 30% odmerka emtricitabina je možno odstraniti s hemodializo v treh urah, če bolnik začne z dializo v roku 1,5 ure po odmerku emtricitabina.
English: Subjects with PDVF evaluated for resistance, n (%)
Slovenian: Preiskovanc i s PDVF, pri katerih so vrednotili odpornost, n (%)
English: Reproductive toxicity studies in rats and rabbits showed no effects on mating, fertility, pregnancy or fetal parameters.
Slovenian: Študije o vplivu na sposobnost razmnoževanja pri podganah in kuncih niso pokazale učinkov na parjenje, plodnost, nosečnost ali parametre pri plodu.
English: Blood and lymphatic system disorders common anaemia
Slovenian: Bolezni krvi in limfatičnega sistema pogosti anemija
English: The interaction profile of darunavir depends on whether ritonavir or cobicistat is used as a pharmacokinetic enhancer; therefore, there may be different recommendations for the use of darunavir with concomitant medicines.
Slovenian: Profil interakcij darunavirja je odvisen od tega, ali gre za sočasno uporabo ritonavirja oziroma kobicistata kot farmakokinetičnih ojačevalcev, zato so pri sočasni uporabi darunavirja z drugimi zdravili lahko priporočila drugačna.
English: Second trimester of pregnancy N = 7
Slovenian: Drugo trimesečje nosečnosti (n=7)
English: Week 48 D/C + F/TDF
Slovenian: v 48. tednu D/C + F/TDF
English: C]-darunavir trial in healthy volunteers showed that a majority of the radioactivity in plasma after a single 400/100 mg darunavir with ritonavir dose was due to the parent active substance.
Slovenian: C, je pri zdravih prostovoljcih pokazala, da je večina radioaktivnosti, izmerjene v plazmi po enkratnem odmerku 400/100 mg darunavirja z ritonavirjem, izhajala iz matične učinkovine.
English: Co-administration of Symtuza and medicinal products primarily metabolised by CYP3A may result in increased systemic exposure to such medicinal products, which could increase or prolong their therapeutic effect and adverse reactions.
Slovenian: Sočasna uporaba zdravila Symtuza in zdravil, ki se primarno presnavljajo s CYP3A, lahko poveča sistemsko izpostavljenost tem zdravilom, kar lahko okrepi ali podaljša njihovo terapevtsko delovanje in neželene učinke.
English: It is not an inhibitor of CYP3A4 in vivo.
Slovenian: In vivo ni zaviralec CYP3A4.
English: Symtuza is an antiretroviral medicine used to treat infection with human immunodeficiency virus 1 (HIV-1).
Slovenian: Zdravilo Symtuza je protiretrovirusno zdravilo, ki se uporablja za zdravljenje okužbe z virusom humane imunske pomanjkljivosti tipa 1 (virusom HIV-1).
English: Symtuza comes in bottles of 30 tablets (with a silica gel desiccant that must be kept in the bottle to help protect your tablets).
Slovenian: Zdravilo Symtuza je na voljo v plastenkah s 30 tabletami (s sušilnim sredstvom iz silikagela, ki mora ostati v vsebniku za zaščito tablet).
English: The pharmacologically active metabolite, tenofovir diphosphate, has a half-life of 150-180 hours within PBMCs.
Slovenian: Razpolovni čas farmakološko aktivnega presnovka tenofovirijevega difosfata v enojedrnih celicah periferne krvi (PBMC) je 150-180 ur.
English: Interaction trials with the components of Symtuza have only been performed in adults.
Slovenian: Študije medsebojnega delovanja z učinkovinami zdravila Symtuza so bile izvedene samo pri odraslih.
English: Your doctor might want to do some additional tests.
Slovenian: Zdravnik vas bo morda moral napotiti na dodatne preiskave.
English: Cobicistat increases serum creatinine due to inhibition of tubular secretion of creatinine without affecting renal glomerular function as assessed, for instance, by using Cystatin C (Cyst C) as filtration marker.
Slovenian: Kobicistat poveča koncentracije kreatinina v serumu z zaviranjem tubulne sekrecije kreatinina, pri tem pa ne vpliva na ledvično glomerulno funkcijo, kar so ocenili na osnovi na primer cistatina C kot označevalca filtracije.
English: However, tenofovir disoproxil reduced the viability index and weight of pups in a peri-postnatal toxicity study at maternally toxic doses.
Slovenian: Vendar pa je dizoproksiltenofovirat zmanjšal indeks viabilnosti in telesno maso mladičev v perinatalni in postnatalni študiji toksičnosti pri odmerkih, toksičnih za mater.
English: It is important not to stop taking Symtuza without talking to your doctor first.
Slovenian: Pomembno je, da zdravila Symtuza ne prenehate jemati, ne da bi se prej pogovorili z zdravnikom.
English: The Symtuza tablets are available in packs containing one bottle or three bottles per carton.
Slovenian: Tablete zdravila Symtuza so na voljo v pakiranju z eno ali tremi plastenkami v škatli.
English: Cobicistat has no detectable antiviral activity against HIV-1 and does not antagonise the antiviral effect of darunavir, emtricitabine, or tenofovir.
Slovenian: Kobicistat nima zaznavne aktivnosti proti virusu HIV-1 in ne deluje antagonistično na protivirusne učinke darunavirja, emtricitabina ali tenofovirja.
English: Darunavir/ritonavir (N = 12)
Slovenian: Izidi v 48. tednu darunavir/ritonavir (n = 12)
English: Mean systemic emtricitabine exposure was higher in patients with severe renal impairment (eGFRCG < 30 mL/min) (33.7 mcg•h/mL) than in subjects with normal renal function (11.8 mcg•h/mL).
Slovenian: Povprečna sistemska izpostavljenost emtricitabinu je bila večja pri bolnikih s hudo okvaro ledvic (eGFRCG < 30 ml/min) (33,7 µg•h/ml) kot pri osebah z normalnim delovanjem ledvic (11,8 µg•h/ml).
English: The decreased susceptibility to darunavir of the emerging viruses in the selection experiment could not be explained by the emergence of these protease mutations.
Slovenian: Zmanjšane občutljivosti na darunavir pri virusih, ki so se v poskusu selekcioniranja pojavljali na novo, ni mogoče pojasniti s pojavljanjem navedenih mutacij v genu za proteazo.
English: In HIV infected patients treated with CART, immune reactivation syndrome has been reported.
Slovenian: Pri bolnikih, okuženih s HIV, ki so prejemali CART so poročali o vnetnem sindromu imunske obnove.
English: The pharmacokinetics of emtricitabine have not been studied in patients with hepatic impairment; however, emtricitabine is not significantly metabolised by liver enzymes, so the impact of liver impairment should be limited.
Slovenian: Farmakokinetičnih lastnosti emtricitabina pri bolnikih z okvaro jeter niso preučevali, vendar jetrni encimi emtricitabina ne presnavljajo v pomembnem obsegu, zato je vpliv okvare jeter pri tem verjetno omejen.
English: It is recommended that the lowest possible dose of digoxin should initially be given to patients on Symtuza.
Slovenian: Priporočljivo je, da bolniki, ki sočasno prejemajo zdravilo Symtuza, na začetku prejemajo najmanjši možni odmerek digoksina.
English: C]-radioactivity showed a time-dependent profile with tenofovir alafenamide as the most abundant species in the initial few hours and uric acid in the remaining period.
Slovenian: C]-radioaktivnost pokazala od časa odvisen profil, pri čemer je bil v prvih nekaj urah za radioaktivnost najbolj pomemben alafenamidtenofovirat, kasneje pa sečna kislina.
English: ethinylestradiol AUC  30% ethinylestradiol Cmax  14% ethinylestradiol Cmin ND
Slovenian: etinilestradiol AUC  30% etinilestradiol Cmax  14% etinilestradiol Cmin ND
English: For monitoring of blood lipids and glucose reference is made to established HIV treatment guidelines.
Slovenian: Za spremljanje lipidov in glukoze v krvi je treba upoštevati veljavne smernice za zdravljenje okužbe z virusom HIV.
English: • vomiting, pain or swelling of the belly, indigestion, flatulence (wind)
Slovenian: • bruhanje, bolečina ali napetost v trebuhu, dispepsija, vetrovi (flatulenca)
English: Due to uncertainties regarding the rate of development of the human blood brain barrier and liver enzymes Symtuza should not be used in paediatric patients below 3 years of age.
Slovenian: Ker hitrost razvoja hematoencefalne bariere in jetrnih encimov pri ljudeh ni zanesljivo določena, se zdravila Symtuza ne sme uporabljati pri pediatričnih bolnikih mlajših od 3 let.
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Slovenian: Poročali so o primerih osteonekroze, še posebej pri bolnikih s splošno znanimi dejavniki tveganja, napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART).
English: PHOSPHODIESTERASE, TYPE 5 (PDE-5) INHIBITORS For the treatment of erectile dysfunction Sildenafil Tadalafil Vardenafil
Slovenian: ZAVIRALCI FOSFODIESTERAZE TIPA 5 (PDE-5) Za zdravljenje motenj erekcije sildenafil tadalafil vardenafil avanafil
English: Latina Italy
Slovenian: Latina Italija
English: Co-administration of Symtuza and budesonide or fluticasone is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid side effects.
Slovenian: Sočasna uporaba zdravila Symtuza in budezonida ali flutikazona ni priporočljiva, razen če morebitna korist zdravljenja odtehta tveganja uporabe sistemskih kortikosteroidov.
English: Tenofovir alafenamide is transported by P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP).
Slovenian: Alafenamidtenofovirat se prenaša s P-glikoproteinom (P-gp) in proteinom rezistence pri raku dojke (BCRP-Breast Cancer Resistance Protein).
English: p < 0.001 for all 4 lipid parameters when comparing D/C/F/TAF versus D/C + F/TDF at Week 48 No comparator data available beyond Week 48
Slovenian: p < 0,001 za vse 4 lipidne parametre pri primerjavi podatkov med skupinama D/C/F/TAF in D/C + F/TDF v 48. tednu Podatki po 48. tednu za primerjalno skupino niso na voljo.
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to combination antiretroviral therapy (CART).
Slovenian: Kljub temu, da so ocenili, da je vzrokov več (vključno z uporabo kortikosteroidov, uživanjem alkohola, hudo imunosupresijo in večjim indeksom telesne mase), so poročali o primerih osteonekroze, še posebej pri bolnikih z napredovalo okužbo z virusom HIV in/ali dolgotrajno izpostavljenostjo kombiniranemu protiretrovirusnemu zdravljenju (CART-Combination Antiretroviral Therapy).
English: Total cholesterol (mmol/L) LDL cholesterol (mmol/L) HDL cholesterol (mmol/L) Triglycerides (mmol/L)
Slovenian: celokupni holesterol (mmol/l) LDL-holesterol (mmol/l)
English: Concomitant use of Symtuza may increase the risk for development of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression.
Slovenian: Sočasna uporaba zdravila Symtuza lahko poveča tveganje za pojav sistemskih kortikosteroidnih učinkov, vključno s Cushingovim sindromom in supresijo nadledvične žleze.
English: Based on animal studies, no effect on reproduction or fertility is expected with Symtuza.
Slovenian: Na osnovi študij na živalih ni pričakovati, da bi zdravilo Symtuza vplivalo na sposobnost razmnoževanja ali plodnost.
English: If overdose occurs the patient must be monitored for evidence of toxicity (see section 4.8).
Slovenian: V primeru prevelikega odmerjanja, je treba bolnika opazovati glede znakov toksičnosti (glejte poglavje 4.8).
English: There was no effect on mating or fertility in animals (see section 5.3).
Slovenian: Pri živalih te učinkovine niso vplivale na parjenje ali plodnost (glejte poglavje 5.3).
English: 111-1921 x 10
Slovenian: 3 (od 111 do 1921 x 10
English: Symtuza, therefore, must not be combined with medicinal products that are highly dependent on CYP3A for clearance and for which increased systemic exposure is associated with serious and/or life-threatening events (narrow therapeutic index) (see section 4.3 or table below).
Slovenian: Zato se zdravila Symtuza ne sme uporabljati v kombinaciji z zdravili, katerih očistek je močno odvisno od CYP3A, povečana sistemska izpostavljenost tem zdravilom pa je povezana z resnimi in/ali življenjsko nevarnimi dogodki (imajo ozko terapevtsko okno) (glejte poglavje 4.3 ali spodnjo preglednico).
English: Patients were allowed in the study if they had previous failure on any non-darunavir ARV regimen.
Slovenian: Bolnike so lahko vključili v študijo, če je pri njih prej prišlo do neuspeha zdravljenja s katerim od protiretrovirusnih režimov, ki niso vsebovali darunavirja.
English: Darunavir is primarily metabolised and eliminated by the liver.
Slovenian: Darunavir se presnavlja in izloča predvsem skozi jetra.
English: Third trimester of pregnancy N = 6
Slovenian: Tretje trimesečje nosečnosti (n=6)
English: Therapeutic drug monitoring of voriconazole, posaconazole or itraconazole is recommended.
Slovenian: Priporočljivo je spremljanje terapevtskih koncentracij vorikonazola, posakonazola oziroma itrakonazola.
English: Population pharmacokinetic analysis in HIV infected patients showed that darunavir pharmacokinetics are not considerably different in the age range (18 to 75 years) evaluated in HIV infected patients (N = 12, age ≥ 65 years) (see section 4.4).
Slovenian: Populacijska analiza farmakokinetike pri bolnikih okuženih s HIV je pokazala, da farmakokinetika darunavirja ni bistveno drugačna v razponu starosti, ki so ga preučevali pri bolnikih, okuženih s HIV (od 18 do 75 let) (n = 12, starost  65 let) (glejte poglavje 4.4).
English: If Symtuza is co-administered with parenteral midazolam, it should be done in an intensive care unit or similar setting, which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Slovenian: Če je treba zdravilo Symtuza uporabljati sočasno s parenteralno obliko midazolama, ju je treba odmerjati na oddelku intenzivne terapije ali v podobni enoti, kar zagotavlja skrbno spremljanje bolnika in ustrezno zdravljenje v primeru depresije dihanja in/ali dolgotrajne sedacije.
English: The safety and efficacy of Symtuza in patients co-infected with HIV-1 and hepatitis C virus (HCV) have not been established.
Slovenian: Varnost in učinkovitost zdravila Symtuza pri bolnikih, s sočasno okužbo z virusom HIV-1 in z virusom hepatitisa C, nista bili dokazani.
English: • a reaction called DRESS [severe rash, which may be accompanied by fever, fatigue, swelling of the face or lymph glands, increase of eosinophils (type of white blood cells), effects on liver, kidney or lung].
Slovenian: • reakcija, ki jo imenujemo DRESS [hud izpuščaj, ki ga včasih spremljajo zvišana telesna temperatura, utrujenost, otekanje obraza in bezgavk, povečano število eozinofilcev (oblika belih krvnih celic) in učinki na jetra, ledvica ali pljuča].
English: Nucleoside and nucleotide analogues have been demonstrated in vitro and in vivo to cause a variable degree of mitochondrial damage.
Slovenian: Pokazalo se je, da lahko nukleozidni in nukleotidni analogi in vitro in in vivo povzročijo različne stopnje okvare mitohondrijev.
English: The recommended dose for adults and adolescents 12 years of age and older, who weigh at least 40 kg is one tablet each day with food.
Slovenian: Priporočeni odmerek za odrasle in mladostnike, ki so stari 12 let ali več, s telesno maso vsaj 40 kg, je ena tableta vsak dan s hrano.
English: Prior data with ritonavir-boosted darunavir however showed a decrease in these anti-depressant plasma concentrations (unknown mechanism); the latter may be specific to ritonavir.
Slovenian: Predhodni podatki o uporabi darunavirja, okrepljenega z ritonavirjem kažejo, da je prišlo do zmanjšanja plazemskih koncentracij navedenih antidepresivov (mehanizem ni znan), kar je verjetno specifično za ritonavir.
English: It is not known whether the co-administration of tenofovir alafenamide and xanthine oxidase inhibitors (e.g. febuxostat) would increase systemic exposure to tenofovir.
Slovenian: Ni znano, ali sočasna uporaba alafenamidtenofovirata in zaviralcev ksantin oksidaze (npr. febuksostata) lahko poveča sistemsko izpostavljenost tenofovirju.
English: The data from these studies showed that the overall safety profile of components of Symtuza in paediatric patients aged 12 to < 18 years and weighing at least 40 kg was similar to that observed in the adult population (see section 5.1).
Slovenian: Po podatkih teh študij je skupen varnostni profil učinkovin zdravila Symtuza pri pediatričnih bolnikih, ki so stari 12 do < 18 let in s telesno maso najmanj 40 kg, podoben tistemu, ki so ga opažali pri odraslih (glejte poglavje 5.1).
English: Medicinal products that strongly affect P-gp activity and BCRP may lead to changes in tenofovir alafenamide absorption.
Slovenian: Zdravila, ki močno vplivajo na aktivnost P-glikoproteina in BCRP, lahko vplivajo na absorpcijo alafenamidtenofovirata.
English: Co-administration of emtricitabine with medicinal products that are eliminated by active tubular secretion may increase concentrations of emtricitabine, and/or the co-administered medicinal product.
Slovenian: Sočasna uporaba emtricitabina z zdravili, ki se izločajo z aktivno tubulno sekrecijo, lahko poveča koncentracijo emtricitabina in/ali sočasno uporabljenih zdravil.
English: In vitro studies indicate that emtricitabine is not an inhibitor of human CYP enzymes.
Slovenian: Rezultati študij in vitro kažejo, da emtricitabin pri človeku ni zaviralec encimov CYP.
English: Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets
Slovenian: Symtuza 800 mg/150 mg/200 mg/10 mg filmsko obložene tablete
English: your doctor may have to check your blood.
Slovenian: Zdravnik vas bo morda moral napotiti na krvne preiskave.
English: If concomitant use of Symtuza with sildenafil, vardenafil or tadalafil is indicated, sildenafil at a single dose not exceeding 25 mg in 48 hours, vardenafil at a single dose not exceeding 2.5 mg in 72 hours or tadalafil at a single dose not exceeding 10 mg in 72 hours is recommended.
Slovenian: Če je indicirana sočasna uporaba zdravila Symtuza in sildenafila, vardenafila ali tadalafila, je priporočljivo uporabiti sildenafil v enkratnem odmerku največ 25 mg v 48 urah, vardenafil v enkratnem odmerku največ 2,5 mg v 72 urah, tadalafil pa v enkratnem odmerku največ 10 mg v 72 urah.
English: A long term carcinogenicity study of cobicistat in rats revealed tumourigenic potential specific for this species, that is regarded as of no relevance for humans.
Slovenian: Dolgoročne študije kancerogenosti kobicistata na podganah so pokazale kancerogeni potencial, ki je specifičen za navedeno vrsto, za ljudi pa naj ne bi imel pomena.
English: Based on this limited experience, the safety profile of emtricitabine/tenofovir alafenamide in patients with HIV/HBV co-infection appears to be similar to that in patients with HIV-1 monoinfection (see section 4.4).
Slovenian: Na osnovi teh omejenih izkušenj kaže, da je varnostni profil kombinacije emtricitabina in alafenamidtenofovirata pri bolnikih s sočasno okužbo z virusom HIV in virusom hepatitisa B podoben kot pri bolnikih, ki imajo samo okužbo z virusom HIV-1 (glejte poglavje 4.4).
English: C]-darunavir with ritonavir showed that approximately 7.7% of the administered dose of darunavir is excreted in the urine unchanged.
Slovenian: C označenim darunavirjem in ritonavirjem so pokazali, da se približno 7,7% danega odmerka darunavirja izloči z urinom v nespremenjeni obliki.
English: Concentrations of these medicinal products may be increased when co-administered with Symtuza resulting in the potential for increased adverse events usually associated with these medicinal products.
Slovenian: Koncentracije navedenih zdravil se lahko pri sočasnem dajanju z zdravilom Symtuza povečajo, kar lahko poveča možnost za neželene učinke, ki se običajno pojavljajo pri uporabi teh zdravil.
English: The median baseline CD4+ cell count was 628 x 10
Slovenian: Povprečno izhodiščno število celic CD4+ je bilo 628 x 10
English: ANTACIDS Aluminium/magnesium hydroxide
Slovenian: ANTACIDI aluminijev/magnezijev hidroksid kalcijev karbonat
English: Yellow to yellowish-brown capsule shaped tablet of 22 mm x 11 mm, debossed with “8121” on one side and “JG” on the other side.
Slovenian: Rumena do rumenkasto rjava tableta v obliki kapsule velikosti 22 mm x 11 mm, z vtisnjenima oznakama “8121” na eni strani in “JG” na drugi.
English: ALPHA ADRENORECEPTOR ANTAGONISTS Alfusozin
Slovenian: ANTAGONIST ADRENERGIČNIH RECEPTORJEV ALFA alfuzosin
English: If switching from ritonavir as a pharmacoenhancer to this regimen with cobicistat, caution is required during the first two weeks of treatment with Symtuza, particularly if doses of any concomitantly administered medicinal products have been titrated or adjusted during use of ritonavir.
Slovenian: Pri prehodu s farmakokinetičnega ojačevalca ritonavirja na kobicistat je prva dva tedna zdravljenja z zdravilom Symtuza potrebna previdnost, zlasti če so bili odmerki sočasno uporabljenega zdravila med zdravljenjem z ritonavirjem titrirani ali prilagojeni.
English: Some side effects are typical for anti-HIV medicines similar to Symtuza.
Slovenian: Nekateri neželeni učinki so značilni za skupino zdravil proti okužbi z virusom HIV, ki so podobnizdravilu Symtuza.
English: These may include yellowing of your skin or whites of your eyes, dark (tea coloured) urine, pale-coloured stools (bowel movements), nausea, vomiting, loss of appetite, or pain, aching, or pain and discomfort on your right side below your ribs.
Slovenian: Ti lahko vključujejo rumenenje kože ali očesnih beločnic, temno obarvan urin (v barvi čaja), svetlo blato (odvajanje blata), slabost, bruhanje, izgubo apetita ali bolečino oziroma občutljivost na desni strani telesa, pod rebri.
English: The emtricitabine-resistant virus with the M184M/I/V mutation was cross-resistant to lamivudine, but retained sensitivity to abacavir, stavudine, tenofovir, and zidovudine.
Slovenian: Virus z odpornostjo na emtricitabin in mutacijo M184M/I/V je bil navzkrižno odporen na lamivudin, vendar je ohranil občutljivost za abakavir, stavudin, tenofovir in zidovudin.
English: Symtuza reduces HIV-1 in your body and this will improve your immune system (your body's natural defences) and reduce the risk of developing illnesses linked to HIV infection but Symtuza is not a cure for HIV infection.
Slovenian: S tem se vaš imunski sistem (naravna obramba vašega telesa) izboljša in zmanjša se tveganje za razvoj bolezni, povezanih z okužbo s HIV, vendar okužbe z virusom HIV ne odpravi v celoti.
English: - Colchicine (antigout).
Slovenian: - kolhicin (za zdravljenje putike).