FrancophonIA/ELRC3.0 huggingface dataset:
English: Diarrhoea can be potentially life-threatening if accompanied by dehydration, renal insufficiency, neutropenia and/or electrolyte imbalances and fatal cases have been reported.
Croatian: Proljev može biti opasan po život ako je praćen dehidracijom, bubrežnom insuficijencijom, neutropenijom i/ili disbalansom elektrolita, a prijavljeni su i fatalni slučajevi.
English: Lapatinib has in terms of objective responses demonstrated modest activity in the treatment of established CNS metastases.
Croatian: Lapatinib je, što se tiče objektivnih odgovora, pokazao skromnu aktivnost u liječenju utvrđenih metastaza u CNS-u.
English: • Take Tyverb either at least one hour before or at least one hour after food.
Croatian: • Uzmite Tyverb ili najmanje jedan sat prije ili najmanje jedan sat nakon obroka.
English: • If you are pregnant or planning to become pregnant, tell your doctor.
Croatian: • Ako ste trudni ili planirate zatrudnjeti, obavijestite svog liječnika.
English: There was an increased incidence of cardiac toxicity, but these events were comparable in nature and severity to those reported from the lapatinib clinical programme (see section 4.4cardiac toxicity).
Croatian: Incidencija kardiološke toksičnosti je bila povišena, no ti su događaji po prirodi i težini bili usporedivi s događajima prijavljenima u kliničkom programu lapatiniba (vidjeti dio 4.4.kardiološka toksičnost).
English: Other medicines and Tyverb
Croatian: Drugi lijekovi i Tyverb
English: The effect on human fertility is unknown.
Croatian: Učinak na plodnost u ljudi nije poznat.
English: Cardiac toxicity
Croatian: Kardiološka toksičnost
English: • pains in muscles or joints
Croatian: • bolove u mišićima ili zglobovima
English: Lapatinib has not been evaluated in patients with symptomatic cardiac failure.
Croatian: Lapatinib nije procjenjivan u bolesnika sa simptomatskim zatajenjem srca.
English: Liver function (transaminases, bilirubin and alkaline phosphatase) should be monitored before the initiation of treatment and monthly thereafter, or as clinically indicated.
Croatian: Potrebno je procijeniti funkciju jetre (vrijednosti transaminaza, bilirubina i alkalne fosfataze) prije samog početka liječenja te je pratiti nakon toga, jednom mjesečno, ili kako je klinički indicirano.
English: The half-life of lapatinib measured after single doses increases with increasing dose.
Croatian: Poluvijek lapatiniba, mjeren nakon jednokratnih doza, povećavao se s povećanjem doze.
English: OUTER CARTON (14 DAY PACK, PART OF 28 DAY MULTIPACK without blue box)
Croatian: VANJSKA KUTIJA (PAKIRANJE ZA 14 DANA, DIO VIŠESTRUKOG PAKIRANJA ZA 28 DANA bez plavog okvira)
English: • severe skin reaction that might include: rash, red skin, blistering of the lips, eyes or mouth, skin peeling, fever or any combination of these
Croatian: • teške kožne reakcije koje mogu uključivati: osip, crvenilo kože, mjehuriće na usnama, očima ili u ustima, ljuštenje kože, vrućicu i bilo koju kombinaciju navedenih reakcija
English: The most common adverse reactions (>25%) during therapy with lapatinib were gastrointestinal events (such as diarrhoea, nausea, and vomiting) and rash.
Croatian: Najčešće nuspojave (> 25%) tijekom liječenja lapatinibom bile su gastrointestinalne nuspojave (primjerice proljev, mučnina i povraćanje) i osip.
English: Lapatinib plus trastuzumab (N=148)
Croatian: Lapatinib i trastuzumab (N = 148)
English: If a skin reaction occurs a full body examination should be performed at every visit until one month after resolution.
Croatian: Ukoliko se kožna reakcija pojavi potrebno je vršiti pregled kože prilikom svake posjete sve do jedan mjesec nakon povlačenja kožnih promjena.
English: Tyverb should be taken either at least one hour before, or at least one hour after food.
Croatian: Tyverb je potrebno uzeti najmanje jedan sat prije ili najmanje jedan sat nakon obroka.
English: Pharmacotherapeutic group: Antineoplastic agents, other antineoplastic agents, protein kinase inhibitors, ATC code: L01XE07
Croatian: Farmakoterapijska skupina: antineoplastični lijekovi, ostali neoplastični lijekovi, inhibitori protein kinaze, ATK oznaka: L01XE07
English: Tyverb is indicated for the treatment of adult patients with breast cancer, whose tumours overexpress HER2 (ErbB2);
Croatian: Tyverb je indiciran u liječenju odraslih bolesnika s karcinomom dojke čiji tumori pokazuju prekomjernu ekspresiju HER2 (ErbB2);
English: The ΔΔQTcF exceeded the 5 ms threshold and the upper bound 90% CIs exceeded the 10 ms threshold at multiple time points.
Croatian: ΔΔQTcF je premašio prag od 5 ms i gornja granica 90% CI je premašila prag od 10 ms u višekratnim vremenskim točkama.
English: If you do experience symptoms associated with this side effect, these are likely to include an irregular heartbeat and shortness of breath.
Croatian: Ukoliko se simptomi povezani s ovom nuspojavom pojave, vrlo vjerojatno će uključivati nepravilan srčani ritam i nedostatak zraka.
English: The bioavailability of lapatinib is increased up to about 4 times by food, depending on e.g. the fat content in the meal.
Croatian: Uz hranu se bioraspoloživost lapatiniba povećava do oko 4 puta, ovisno npr. o sadržaju masnoća u obroku.
English: When lapatinib is taken in combination with strong CYP3A4 inhibitors the QTc interval can be expected to be prolonged by 16.1 ms (12.6-20.3 ms) as demonstrated in a model-based prediction (see section 4.4).
Croatian: Kada se lapatinib uzima u kombinaciji sa snažnim inhibitorima CYP3A4, može se očekivati produljenje QTc intervala za 16.1 ms (12,6-20,3 ms) kao što je pokazano na predviđanju temeljenom na modelu (vidjeti dio 4.4).
English: The full prescribing information of the co-administered medicinal product should be consulted for relevant details of their posology including any dose reductions, contraindications and safety information.
Croatian: Za lijekove koji se istodobno uzimaju potrebno je pogledati njihove cjelokupne informacije o propisivanju za sve važne detalje o njihovom doziranju, uključujući smanjenje doze, kontraindikacije i informacije o sigurnosti.
English: Peak plasma concentrations (Cmax) of lapatinib are achieved approximately 4 hours after administration.
Croatian: Maksimalne koncentracije u plazmi (Cmax) lapatiniba postižu se oko 4 sata nakon unosa.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Tyverb in all subsets of the paediatric population in the treatment of breast carcinoma (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Tyverb u svim podskupinama pedijatrijske populacije u liječenju karcinoma dojke (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: • If you become pregnant during treatment with Tyverb, tell your doctor.
Croatian: • Ako zatrudnite tijekom liječenja lijekom Tyverb, obavijestite svog liječnika.
English: In the prevention of CNS metastases in the metastatic and early breast cancer settings the observed activity was limited.
Croatian: U prevenciji metastaza u CNS-u u liječenju metastatskog i ranog stadija karcinoma dojke, uočena aktivnost bila je ograničena.
English: Inhibitors (ketoconazole, itraconazole, quinidine, verapamil, cyclosporine, and erythromycin) and inducers (rifampicin and St John's Wort) of these proteins may alter the exposure and/or distribution of lapatinib (see section 5.2).
Croatian: Inhibitori (ketokonazol, itrakonazol, kinidin, verapamil, ciklosporin, i eritromicin) i induktori (rifampicin i gospina trava) ovih proteina mogu promijeniti izloženost i/ili distribuciju lapatiniba (vidjeti dio 5.2).
English: Concomitant administration of Tyverb with capecitabine, letrozole or trastuzumab did not meaningfully alter the pharmacokinetics of these medicinal products (or the metabolites of capecitabine) or lapatinib.
Croatian: Istodobna primjena lijeka Tyverb s kapecitabinom, letrozolom ili trastuzumabom nije značajno promijenila farmakokinetiku ovih lijekova (ili metabolite kapecitabina) ili lapatiniba.
English: Less than 2% of the administered oral dose (as lapatinib and metabolites) excreted in urine.
Croatian: Manje od 2% unesene oralne doze (lapatiniba i metabolita) izlučuje se putem urina.
English: Diarrhoea responds well to proactive management (see section 4.4).
Croatian: Proljev dobro reagira na proaktivno zbrinjavanje (vidjeti dio 4.4).
English: The effect of lapatinib on the QT-interval was evaluated in a single-blind, placebo-controlled, single sequence (placebo and active treatment) crossover study in patients with advanced solid tumours (EGF114271) (n=58).
Croatian: Učinak lapatiniba na QT interval je procijenjen u jednostruko slijepom, placebom kontroliranom, ukriženom ispitivanju s jednom sekvencom (placebo i aktivno liječenje) u bolesnika s uznapredovalim solidnim tumorima (EGF114271) (n=58).
English: Systemic exposure (AUC) to lapatinib after a single oral 100 mg dose increased approximately 56% and 85% in patients with moderate and severe hepatic impairment, respectively.
Croatian: Sistemska izloženost (AUC) lapatinibu nakon jednokratne oralne doze od 100 mg se povećala za oko 56% i 85% u ispitanika s umjerenim odnosno teškim oštećenjem funkcije jetre.
English: Tyverb has no influence on the ability to drive and use machines.
Croatian: Tyverb ne utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Pre-treatment with a proton pump inhibitor (esomeprazole) decreased lapatinib exposure by an average of 27% (range: 6% to 49%).
Croatian: Prethodna primjena inhibitora protonske pumpe (esomeprazola) snizila je izloženost lapatinibu za prosječno 27% (raspon od 6% do 49%).
English: The patients in the registration study were not previously treated with trastuzumab or an aromatase inhibitor (see sections 4.4. and 5.1).
Croatian: Bolesnice u registracijskom ispitivanju nisu bile prethodno liječene trastuzumabom ili inhibitorom aromataze (vidjeti dio 4.4 i 5.1).
English: Your doctor will advise you about the dose of your other anti-cancer medicine, and how to take it.
Croatian: Liječnik će Vas savjetovati o dozi drugih antitumorskih lijekova koje trebate uzimati kao i o načinu njihova uzimanja.
English: The cardiac events observed in this study were comparable in nature and severity to those previously seen with lapatinib.
Croatian: Kardiološki događaji zabilježeni u ovom ispitivanju po prirodi i težini se mogu usporediti s prethodno zabilježenim događajima s lapatinibom.
English: An additional increase in peak exposure of lapatinib can be expected when lapatinib is taken repeatedly with food (see sections 4.2 and 5.2) or concomitantly with strong CYP3A4 inhibitors.
Croatian: Dodatno povećanje u vršnoj izloženosti lapatinibu može se očekivati kada se lapatinib opetovano uzima s hranom (vidjeti dijelove 4.2 i 5.2) ili istodobno sa snažnim inhibitorima CYP3A4.
English: During the 4-day treatment period, three doses of matching placebo were administered 12 hours apart in the morning and evening on Day 1 and in the morning on Day 2.
Croatian: Tijekom četverodnevnog perioda liječenja, tri doze koje odgovaraju placebu su bile primijenjene u razmaku od 12 sati ujutro i navečer 1. dana, te ujutro 2. dan.
English: In the phase III clinical study of Tyverb in combination with letrozole, of the total number of hormone receptor positive metastatic breast cancer patients (Intent to treat population N= 642), 44 % were ≥ 65 years of age.
Croatian: U fazi III kliničkog ispitivanja kombinacije lijeka Tyverb i letrozola, od ukupnog broja bolesnika s metastatskim rakom dojke pozitivnim na hormonske receptore (populacija planirana za liječenje n= 642), 44% njih je bilo dobi ≥ 65 godina.
English: Of all patients randomised to treatment, 219 patients had tumours overexpressing the HER2 receptor, and this was the pre-specified primary population for the analysis of efficacy.
Croatian: Od svih randomiziranih bolesnica za liječenje, 219 bolesnica je imalo tumore s prekomjernom ekspresijom HER2 receptora i to je bila prethodno definirana primarna skupina ispitanika za analizu djelotvornosti.
English: The effect of Tyverb during pregnancy is not known.
Croatian: Učinak lijeka Tyverb na trudnoću nije poznat.
English: If you suffer from diarrhoea while taking Tyverb:
Croatian: Ukoliko imate proljev dok uzimate Tyverb:
English: Hyperbilirubinaemia, hepatotoxicity (see section 4.4).
Croatian: Hiperbilirubinemija, hepatotoksičnost (vidjeti dio 4.4).
English: Asymptomatic and symptomatic cases of overdose have been reported in patients being treated with Tyverb.
Croatian: Prijavljeni su asimptomatski i simptomatski slučajevi predoziranja u bolesnika koji su liječeni lijekom Tyverb.
English: To minimise variability in the individual patient, administration of Tyverb should be standardised in relation to food intake, for example always to be taken one hour before a meal (see sections 4.5 and 5.2 for information on absorption).
Croatian: U svrhu smanjenja varijabilnosti u pojedinog bolesnika primjenu lijeka Tyverb potrebno je standardizirati u odnosu na unos hrane, na primjer, uvijek ga uzimati jedan sat prije obroka (vidjeti dijelove 4.5 i 5.2 za informacije o apsorpciji).
English: HER2 (ErbB2) overexpressing tumours are defined by IHC3+, or IHC2+ with gene amplification or gene amplification alone.
Croatian: Tumori koji pokazuju prekomjernu ekspresiju HER2 (ErbB2) definirani su rezultatom IHC3+, ili IHC2+ uz amplifikaciju gena, ili samom amplifikacijom gena.
English: Measurements, including electrocardiograms (ECGs) and pharmacokinetic samples, were taken at baseline and at the same time points on Day 2 and Day 4.
Croatian: Mjerenja, uključujući elektrokardiograme (EKG) i farmakokinetičke uzorke, su provedena na početku i u istim vremenskim točkama 2. i 4. dana.
English: • if you have diarrhoea (see section 4).
Croatian: • ako imate proljev (pogledajte dio 4.).
English: Tyverb is also available in multipacks containing 140 tablets that comprise 2 packs, each containing 70 tablets.
Croatian: Tyverb je također dostupan u višestrukim pakiranjima koja sadrže 140 tableta, a sastoje se od 2 pakiranja, svako sa 70 tableta.
English: Patients who had objective disease progression after receiving at least 4 weeks of treatment with lapatinib monotherapy were eligible to crossover to combination therapy.
Croatian: Bolesnici kojima je bolest objektivno progredirala nakon najmanje 4 tjedna liječenja monoterapijom lapatinibom mogli su prijeći na kombiniranu terapiju.
English: Lapatinib has been associated with reports of pulmonary toxicity including interstitial lung disease and pneumonitis (see section 4.8).
Croatian: Lapatinib je povezan s prijavama plućne toksičnosti, uključujući intersticijsku bolest pluća i pneumonitis (vidjeti dio 4.8).
English: In patients who took up to 5000 mg of lapatinib, symptoms observed include known lapatinib associated events (see section 4.8) and in some cases sore scalp and/or mucosal inflammation.
Croatian: U bolesnika koji su uzeli do 5000 mg lapatiniba primijećeni su simptomi koji uključuju s lapatinibom povezane događaje (vidjeti dio 4.8) i, u nekim slučajevima, osjetljivo vlasište i/ili upale sluznice.
English: Lapatinib is predominantly eliminated through metabolism by CYP3A4/5.
Croatian: Lapatinib se uglavnom eliminira putem metabolizma pomoću CYP3A4/5.
English: If erythema multiforme or life-threatening reactions such as Stevens-Johnson syndrome, or toxic epidermal necrolysis (e.g. progressive skin rash often with blisters or mucosal lesions) are suspected, discontinue treatment with Tyverb.
Croatian: Ako se posumnja na pojavu eritema multiforme ili na reakcije opasne po život poput Stevens-Johnsonovog sindroma ili toksičnu epidermalnu nekrolizu (npr. progresivni kožni osip često s mjehurićima ili lezijama sluznica), potrebno je prekinuti liječenje lijekom Tyverb.
English: However, the occurrence of docetaxel-induced neutropenia was increased.
Croatian: Ipak, porasla je pojavnost docetakselom inducirane neutropenije.
English: Final OS analysis (post-hoc analysis, 07 August 2013) Median follow-up (yrs) Deaths (%) Hazard ratio (95% CI), p-value Median values from Kaplan-Meier analysis; HR and p-values from Cox regression models adjusting for important prognostic factors.
Croatian: Završna analiza OS-a (post-hoc analiza, 07. kolovoza 2013.) Medijan praćenja (godine) Smrtni ishodi (%) Omjer hazarda (95% CI), pvrijednost Vrijednosti medijana iz Kaplan-Meier-ove analize; Omjer hazarda i p-vrijednosti iz Cox regresijskog modela prilagođeni za važne prognostičke čimbenike. a.
English: A randomised Phase III study (EGF111438) (N=540) compared the effect of the two regimens on the incidence of CNS as site of first relapse in women with HER2 overexpressing metastatic breast cancer.
Croatian: Randomizirano ispitivanje faze III (EGF111438) (N=450) uspoređivalo je učinak dva režima na incidenciju metastaza u CNS-u kao mjestu prvog relapsa u žena s metastatskim karcinomom dojke s prekomjernom HER2 ekspresijom.
English: Tell your doctor or pharmacist if you notice any side effects not listed in this leaflet.
Croatian: Odmah obavijestite svog liječnika ili ljekarnika ako primijetite nuspojave koje nisu navedene u ovoj uputi.
English: You should not use Tyverb if you are pregnant unless your doctor specifically recommends it.
Croatian: Tyverb se ne smije uzimati u trudoći, osim ako to Vaš liječnik izričito ne preporuči.
English: Lapatinib alone (N=148 )
Croatian: Samo lapatinib (N = 148)
English: Adverse reactions should be carefully monitored if Tyverb is co-administered with irinotecan, and a reduction in the dose of irinotecan should be considered.
Croatian: Nuspojave je potrebno pažljivo nadzirati ukoliko se Tyverb primjenjuje istodobno s irinotekanom te je potrebno razmišljati i o mogućem smanjenju doze irinotekana.
English: The independent assessment of the data also demonstrated that Tyverb when given in combination with capecitabine significantly increased time to progression (Hazard Ratio 0.57 [95 % CI 0.43, 0.77] p=0.0001) compared to capecitabine alone.
Croatian: Neovisna ocjena podataka također je pokazala da je Tyverb u kombinaciji s kapecitabinom značajno produžio vrijeme do progresije (omjer hazarda 0,57 [95% CI 0,43; 0,77] p=0,0001) u usporedbi s monoterapijom kapecitabinom.
English: In the HER2-overexpressing population, only 2 patients were enrolled who had received prior trastuzumab, 2 patients had received prior aromatase inhibitor therapy, and approximately half had received tamoxifen.
Croatian: U populaciji s prekomjernom ekspresijom HER2 uključene su samo 2 bolesnice koje su prethodno primale trastuzumab, 2 bolesnice prethodno liječene inhibitorima aromataze, a približno polovica bolesnica primala je tamoksifen.
English: Diarrhoea generally occurs early during Tyverb treatment, with almost half of those patients with diarrhoea first experiencing it within 6 days.
Croatian: Proljev se u pravilu pojavljuje rano tijekom liječenja lijekom Tyverb, a u gotovo polovice tih bolesnika se proljev prvi put javi unutar prvih 6 dana.
English: • diarrhoea (which may make you dehydrated and lead to more severe complications) Tell your doctor immediately at the first sign of diarrhoea (loose stool), as it is important that this is treated right away.
Croatian: • proljev (koji može dovesti do dehidracije i težih komplikacija) Obavijestite svog liječnika bez odlaganja kod prvih znakova proljeva (rijetke stolice) jer je važno da se odmah počne liječiti.
English: Symptoms may include skin rash, blisters and skin peeling.
Croatian: Simptomi mogu uključivati kožni osip, mjehuriće i ljuštenje kože.
English: Lapatinib is not significantly renally excreted and is highly bound to plasma proteins, therefore haemodialysis would not be expected to be an effective method to enhance the elimination of lapatinib.
Croatian: Lapatinib se ne izlučuje putem bubrega u značajnoj mjeri i uvelike se veže za proteine plazme te se stoga hemodijaliza ne smatra učinkovitom metodom za pojačanje eliminacije lapatiniba.
English: BLISTERS
Croatian: Blisteri
English: 8.2 wks (7.4, 9.3)
Croatian: 8,2 tjedana (7,4; 9,3)
English: Lapatinib is highly bound (greater than 99%) to albumin and alpha-1 acid glycoprotein.
Croatian: Lapatinib se u visokoj mjeri (više od 99%) veže za albumin i alfa-1 kiseli glikoprotein.
English: • nail disorders - such as a tender infection and swelling of the cuticles Tell your doctor if you get any of these symptoms.
Croatian: • Poremećaji noktiju - kao što su blage infekcije ili oticanje zanoktica Obavijestite svog liječnika ako Vam se pojavi bilo koji od ovih simptoma.
English: Data are available on the efficacy and safety of Tyverb in combination with capecitabine relative to trastuzumab in combination with capecitabine.
Croatian: Dostupni su podaci o djelotvornosti i sigurnosti Tyverba u kombinaciji s kapecitabinom u odnosu na trastuzumab u kombinaciji s kapecitabinom.
English: Hypersensitivity reactions including anaphylaxis (see section 4.3) Metabolism and nutrition disorders Very common Anorexia
Croatian: Reakcije preosjetljivosti uključujući anafilaksiju (vidjeti dio 4.3) Poremećaji metabolizma i prehrane Vrlo često
English: The risk of lapatinib-induced hepatotoxicity was associated with carriage of the HLA alleles DQA1*02:01 and DRB1*07:01 (see section 4.4).
Croatian: Rizik od hepatotoksičnosti izazvane lapatinibom bio je povezan s nositeljstvom HLA alela DQA1*02:01 i DRB1*07:01 (vidjeti dio 4.4.).
English: In studies across the clinical development programme for lapatinib, cardiac events including LVEF decreases were reported in approximately 1% of patients.
Croatian: U ispitivanjima koja su se provodila tijekom cijelog programa kliničkog razvoja lapatiniba, kardiološki događaji uključujući smanjenje LVEF prijavljeni su u oko 1% bolesnika.
English: Ask your doctor or pharmacist for advice before taking Tyverb if you are unsure.
Croatian: Posavjetujte se s Vašim liječnikom ili ljekarnikom prije početka uzimanja Tyverba ako u nešto niste sigurni.
English: In rats, growth retardation was observed in pups which were exposed to lapatinib via breast milk.
Croatian: Kod štakora je primijećeno zaostajanje u rastu kod mladunčadi koja je bila izložena lapatinibu putem majčinog mlijeka.
English: Co-administration of Tyverb with irinotecan (when administered as part of the FOLFIRI regimen) resulted in an approximate 40% increase in the AUC of SN-38, the active metabolite of irinotecan.
Croatian: Istodobna primjena lijeka Tyverb i irinotekana (kada se primjenjuje kao dio FOLFIRI protokola) uzrokovala je približno 40%-tno povećanje AUC za SN-38 koji je aktivni metabolit irinotekana.
English: Progression-free survival (PFS) was the primary endpoint of the study with response rate and overall survival (OS) as secondary endpoints.
Croatian: Preživljenje bez progresije (PFS) bio je primarni ishod ispitivanja, a sekundarni ishodi bili su stopa odgovora i ukupno preživljenje (OS).
English: On the combination arm, there were 4 (2%) progressions in the central nervous system as compared with the 13 (6%) progressions on the capecitabine alone arm.
Croatian: U kombiniranom liječenju bilo je 4 (2%) progresije u središnjem živčanom sustavu u usporedbi s 13 (6%) progresija u monoterapiji kapecitabinom.
English: The relevance of these findings for humans is uncertain.
Croatian: Značenje ovih nalaza za ljude nije poznato.
English: In a single case of a patient who took 9000 mg of Tyverb, sinus tachycardia (with otherwise normal ECG) was also observed.
Croatian: U jednom je slučaju u bolesnika koji je uzeo 9000 mg lijeka Tyverb zabilježena sinusna tahikardija (uz inače normalan EKG nalaz).
English: • treatment-induced lung inflammation, which may cause shortness of breath or cough Tell your doctor immediately if you get either of these symptoms.
Croatian: • upala pluća potaknuta primjenom lijeka, što može dovesti do nedostatka zraka ili kašlja Odmah obavijestite svog liječnika ako dobijete neki od ovih simptoma.