FrancophonIA/ELRC3.0 huggingface dataset:
English: MVASI should be discontinued in patients with life-threatening (grade 4) thromboembolic reactions, including pulmonary embolism (NCI-CTCAE v.3).
Croatian: Primjenu lijeka MVASI treba prekinuti u bolesnika s tromboembolijskim reakcijama opasnima po život (stupanj 4), uključujući plućnu emboliju (NCI-CTCAE v.3).
English: Cases of ONJ have been reported in cancer patients treated with bevacizumab, the majority of whom had received prior or concomitant treatment with intravenous bisphosphonates, for which ONJ is an identified risk.
Croatian: Prijavljeni su slučajevi osteonekroze čeljusti u bolesnika s malignom bolešću liječenih bevacizumabom, od kojih je većina prethodno ili istodobno primala intravenske bisfosfonate, kod čije primjene osteonekroza čeljusti predstavlja poznat rizik.
English: The study did not meet its primary endpoint of demonstrating a significant improvement of event free survival (EFS) (Central Radiology Review Committee (CRRC)-assessed) when bevacizumab was added to the RT/T arm compared with RT/T alone (HR = 1.44; 95% CI: 0.90, 2.30).
Croatian: Ispitivanje nije postiglo primarnu mjeru ishoda, tj. nije pokazalo značajno poboljšanje preživljenja bez događaja (prema ocjeni središnjeg povjerenstva za radiološku ocjenu) u skupini koja je uz RT/T primala i bevacizumab u odnosu na onu koja je primala samo RT/T (HR = 1,44; 95% CI: 0,90; 2,30).
English: The primary endpoint of this trial was progression-free survival (PFS), based on trial investigators' assessment of disease progression.
Croatian: Primarna mjera ishoda ovog ispitivanja bilo je preživljenje bez progresije bolesti, na temelju ispitivačeve procjene progresije bolesti.
English: In clinical trials across all indications the overall incidence of NCI-CTCAE v.3 grade 3-5 bleeding reactions ranged from 0.4% to 6.9% in bevacizumab-treated patients, compared with up to 4.5% of patients in the chemotherapy control group.
Croatian: U kliničkim ispitivanjima u svim indikacijama ukupna incidencija reakcija krvarenja stupnja 3-5 prema NCI-CTCAE iznosila je od 0,4% do 6,9% u bolesnika liječenih bevacizumabom u odnosu na najviše 4,5% u bolesnika u kontrolnoj skupini liječenoj kemoterapijom.
English: You could also experience redness or flushing of the skin or a rash, chills and shivering, feeling sick (nausea) or being sick (vomiting).
Croatian: Također se mogu javiti crvenilo ili navale crvenila na koži ili osip kože, zimica i drhtanje, mučnina ili povraćanje.
English: Study JO25567 was a randomised, open-label, multi-centre phase II study conducted in Japan to evaluate the efficacy and safety of bevacizumab used in addition to erlotinib in patients with nonsquamous NSCLC with EGFR activating mutations (exon 19 deletion or exon 21 L858R mutation) who had not received prior systemic therapy for stage IIIB/IV or recurrent disease.
Croatian: Ispitivanje JO25567 bilo je randomizirano, otvoreno, multicentrično ispitivanje faze II, provedeno u Japanu s ciljem utvrđivanja djelotvornosti i sigurnosti lijeka bevacizumab kao dodatka erlotinibu u bolesnika oboljelih od neskvamoznog NSCLC-a s aktivirajućim mutacijama EGFR-a (delecija eksona 19 ili mutacija L858R u eksonu 21) koji prethodno nisu primali sistemsku terapiju za bolest stadija IIIB/IV ili recidivirajuću bolest.
English: Exploratory PFS and OS analyses by chemotherapy cohort
Croatian: Tablica 23. Eksploracijske analize PFS-a i OS-a prema kemoterapijskoj kohorti KT
English: Across all clinical trials, mucocutaneous haemorrhage has been seen in up to 50% of bevacizumabtreated patients.
Croatian: U svim je kliničkim ispitivanjima krvarenje u kožu i sluznice zabilježeno u do 50% bolesnika liječenih bevacizumabom.
English: In randomised clinical trials, age > 65 years was associated with an increased risk of developing arterial thromboembolic reactions, including cerebrovascular accidents (CVAs), transient ischaemic attacks (TIAs) and myocardial infarctions (MIs).
Croatian: U randomiziranim kliničkim ispitivanjima pokazalo se da bolesnici stariji od 65 godina imaju povećan rizik za razvoj arterijskih tromboembolijskih reakcija, uključujući cerebrovaskularne incidente (CVI), tranzitorne ishemijske atake (TIA) te infarkte miokarda (IM).
English: (p-value5 = 0.0132)
Croatian: (p-vrijednost5 = 0,0132)
English: • presence of protein in your urine accompanied by swelling of your body,
Croatian: • u slučaju pojave proteina u mokraći i oticanja tijela,
English: MVASI should be discontinued permanently in patients who experience grade 3 or 4 bleeding during bevacizumab therapy (NCI-CTCAE v.3) (see section 4.8).
Croatian: MVASI valja trajno obustaviti u bolesnika u kojih tijekom liječenja ovim lijekom nastupi krvarenje stupnja 3 ili 4 (NCI-CTCAE v.3) (vidjeti dio 4.8).
English: Of the 452 patients randomised at baseline, the majority of patients were white (80.0% in the chemo alone group and 75.3% in the chemo + bevacizumab group), had squamous cell carcinoma (67.1% in the chemo alone group and 69.6% in the chemo + bevacizumab group), had persistent/recurrent disease (83.6% in the chemo alone group and 82.8% in the chemo + bevacizumab group), had 1-2 metastatic sites (72.0% in the chemo alone group and 76.2% in the chemo + bevacizumab group), had lymph node involvement (50.2% in the chemo alone group and 56.4% in the chemo + bevacizumab group), and had a platinum free interval ≥ 6 months (72.5% in the chemo alone group and 64.4% in the chemo + bevacizumab group).
Croatian: Od 452 bolesnice randomizirane na početku ispitivanja većina su bile bjelkinje (80,0% u skupini koja je primala samo kemoterapiju i 75,3% u skupini koja je primala kemoterapiju+bevacizumab) te su većinom imale planocelularni karcinom (67,1% u skupini koja je primala samo kemoterapiju i 69,6% u skupini koja je primala kemoterapiju+bevacizumab), perzistentnu/recidivirajuću bolest (83,6% u skupini koja je primala samo kemoterapiju i 82,8% u skupini koja je primala kemoterapiju+bevacizumab), 1 do 2 metastatska sijela (72,0% u skupini koja je primala samo kemoterapiju i 76,2% u skupini koja je primala kemoterapiju+bevacizumab), zahvaćene limfne čvorove (50,2% u skupini koja je primala samo kemoterapiju i 56,4% u skupini koja je primala kemoterapiju+bevacizumab) i interval bez liječenja platinom ≥ 6 mjeseci (72,5% u skupini koja je primala samo kemoterapiju i 64,4% u skupini koja je primala kemoterapiju+bevacizumab).
English: Progression-free survival and objective response rate were inferior in the bevacizumab monotherapy arm compared to the FOLFOX-4 arm.
Croatian: Preživljenje bez progresije bolesti i stopa objektivnog odgovora bili su lošiji u skupini koja je primala bevacizumab u monoterapiji nego u skupini liječenoj protokolom FOLFOX-4.
English: This was a phase II randomised, double-blind, active-controlled clinical trial evaluating the efficacy and safety of bevacizumab in combination with 5-FU/FA as first-line treatment for metastatic colorectal cancer in patients who were not optimal candidates for first-line irinotecan treatment.
Croatian: Riječ je o randomiziranom, dvostruko slijepom, aktivno kontroliranom kliničkom ispitivanju faze II, u kojemu se određivala djelotvornost i sigurnost primjene bevacizumaba u kombinaciji s protokolom 5-FU/FA kao prve linije liječenja metastatskog kolorektalnog karcinoma u bolesnika koji nisu bili optimalni kandidati za primjenu irinotekana u prvoj liniji liječenja.
English: The median age was 46.0 years (range: 20-83) in the chemo alone group and 48.0 years (range: 22-85) in the chemo + bevacizumab group; with 9.3% of patients in the chemo alone group and 7.5% of patients in the chemo + bevacizumab group over the age of 65 years.
Croatian: Medijan dobi bio je 46,0 godina (raspon: 20-83) u skupini koja je primala samo kemoterapiju, a 48,0 godina (raspon: 22-85) u skupini koja je primala kemoterapiju+bevacizumab; 9,3% bolesnica u skupini koja je primala samo kemoterapiju i 7,5% bolesnica u skupini koja je primala kemoterapiju+bevacizumab bilo je starije od 65 godina.
English: Cases of osteonecrosis of the jaw (ONJ) have been reported in patients treated with bevacizumab, most of which occurred in patients who had identified risk factors for ONJ, in particular exposure to intravenous bisphosphonates and/or a history of dental disease requiring invasive dental procedures (see also section 4.4) Cases of non-mandibular osteonecrosis have been observed in bevacizumab-treated paediatric patients (see section 4.8, Paediatric population)
Croatian: Prijavljeni su slučajevi osteonekroze čeljusti u bolesnika liječenih bevacizumabom, većinom u bolesnika koji su imali poznate čimbenike rizika za osteonekrozu čeljusti, osobito izloženost intravenskim bisfosfonatima i/ili bolest zuba koja je zahtijevala invazivne stomatološke zahvate u anamnezi (vidjeti i dio 4.4)
English: MVASI, in combination with erlotinib, is indicated for first-line treatment of adult patients with unresectable advanced, metastatic or recurrent non-squamous non-small cell lung cancer with Epidermal Growth Factor Receptor (EGFR) activating mutations (see section 5.1).
Croatian: MVASI je u kombinaciji s erlotinibom indiciran za prvu liniju liječenja odraslih bolesnika s neresektabilnim uznapredovalim, metastatskim ili recidivirajućim neskvamoznim karcinomom pluća nemalih stanica s aktivirajućim mutacijama receptora epidermalnog faktora rasta (engl. epidermal growth factor receptor, EGFR) (vidjeti dio 5.1).
English: There have been rare reports of bevacizumab-treated patients developing signs and symptoms that are consistent with PRES, a rare neurologic disorder, which can present with the following signs and symptoms among others: seizures, headache, altered mental status, visual disturbance, or cortical blindness, with or without associated hypertension.
Croatian: Posterior Reversible Encephalopathy Syndrome, PRES), rijetkog neurološkog poremećaja koji se, između ostalih, manifestira sljedećim znakovima i simptomima: konvulzijama, glavoboljom, promjenom psihičkog stanja, poremećajem vida ili kortikalnim sljepilom, sa ili bez povišenog krvnog tlaka.
English: Relative to the control arm.
Croatian: a u odnosu na kontrolnu skupinu.
English: (p-value = 0.3113)
Croatian: (p - vrijednost = 0,3113)
English: A total of 116 patients were randomised to receive bevacizumab 3 mg/kg every 2 weeks (n = 39), 10 mg/kg every 2 weeks; (n = 37), or placebo (n = 40).
Croatian: Jedna je skupina primala bevacizumab u dozi od 3 mg/kg svaka 2 tjedna (n = 39), druga u dozi od 10 mg/kg svaka 2 tjedna (n = 37), a treća je skupina primala placebo (n = 40).
English: A GOG PS of 2 at baseline was reported in 0.9% of patients in the CP arm and in 1.2% of patients in the CPB arm.
Croatian: GOG funkcionalni status 2 na početku ispitivanja zabilježen je u 0,9% bolesnica u skupini CP te u 1,2% bolesnica u skupini CPB.
English: • stomach and intestinal disorder,
Croatian: • poremećaj želuca i crijeva,
English: Pre-specified PFS analyses were conducted, all with a cut-off date of 29 September 2009.
Croatian: Provedene su unaprijed određene analize preživljenja bez progresije bolesti; u svima je završni datum prikupljanja podataka bio 29. rujna 2009.
English: Median PFS (months) Hazard ratio (95% CI)4 Randomised patients with stage III suboptimally debulked disease3 CP (n = 154)
Croatian: Medijan PFS (mjeseci) Omjer hazarda (95% CI)4 Randomizirane bolesnice sa stadijem III bolesti uz suboptimalno smanjenu tumorsku masu3 CP (n = 154)
English: In study BO20924 of bevacizumab with current standard of care in metastatic rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma, the safety profile of bevacizumab-treated children was comparable with that observed in adults treated with bevacizumab.
Croatian: U ispitivanju BO20924, u kojem se ispitivao bevacizumab s trenutnom standardnom terapijom u liječenju metastatskog rabdomiosarkoma i sarkoma mekog tkiva koji nije rabdomiosarkom, sigurnosni profil lijeka u djece liječene bevacizumabom bio je usporediv s onim primijećenim u odraslih osoba liječenih bevacizumabom.
English: Eight hundred and thirteen patients were randomised to receive IFL + placebo (Arm 1) or IFL + bevacizumab (5 mg/kg every 2 weeks, Arm 2).
Croatian: Randomizirano je 813 bolesnika, u skupinu koja je primala IFL + placebo (skupina 1) ili u skupinu koja je primala IFL + bevacizumab (5 mg/kg svaka 2 tjedna, skupina 2).
English: Efficacy results from study GOG-0218
Croatian: Rezultati djelotvornosti za ispitivanje GOG-0218
English: MVASI will be administered in combination with chemotherapy treatment containing a fluoropyrimidine medicine.
Croatian: MVASI će se davati u kombinaciji s kemoterapijom koja sadrži lijek na bazi fluoropirimidina.
English: The trial contained two parts: an initial unblinded 2-arm part (Part I) in which patients were randomised to two different treatment groups (XELOX and FOLFOX-4) and a subsequent 2 x 2 factorial 4-arm part (Part II) in which patients were randomised to four treatment groups (XELOX + placebo, FOLFOX-4 + placebo, XELOX + bevacizumab, FOLFOX-4 + bevacizumab).
Croatian: U sljedećem dijelu (dio II) sastavljenom od 4 skupine prema faktorijalnom nacrtu 2 x 2 bolesnici su randomizirani u četiri terapijske skupine (XELOX + placebo, FOLFOX-4 + placebo, XELOX + bevacizumab, FOLFOX-4 + bevacizumab).
English: MVASI is for intravenous use.
Croatian: MVASI se primjenjuje intravenski.
English: Fluoropyrimidine/irinotecan or Fluoropyrimidine/oxaliplatin based chemotherapy + bevacizumaba
Croatian: kemoterapija na bazi fluoropirimidina/irinotekana ili fluoropirimidina/oksaliplatina kemoterapija na bazi fluoropirimidina/irinotekana ili fluoropirimidina/oksaliplatina + bevacizumaba
English: Addition of bevacizumab to RT/T did not demonstrate clinical benefit in study BO25041 in 60 evaluable children patients with newly diagnosed supratentorial or infratentorial cerebellar or peduncular high-grade glioma (HGG) (see section 4.2 for information on paediatric use).
Croatian: U ispitivanju BO25041, dodavanje bevacizumaba kombinaciji RT/T nije pokazalo kliničku korist u 60 ocjenjive djece s novodijagnosticiranim supratentorijalnim ili infratentorijalnim cerebelarnim ili pedunkularnim gliomom visokog stupnja (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: MVASI therapy should be discontinued in patients who develop necrotising fasciitis, and appropriate treatment should be promptly initiated.
Croatian: U bolesnika u kojih se razvije nekrotizirajući fasciitis terapiju lijekom MVASI treba prekinuti i odmah započeti s odgovarajućim liječenjem.
English: Cisplatin/Gemcitabine + bevacizumab 7.5 mg/kg q 3 weeks
Croatian: Cisplatin/Gemcitabin + bevacizumab 7,5 mg/kg svaka 3 tjedna
English: Gastrointestinal disorders Gastrointestinal ulcer (not known) Hepatobiliary disorders
Croatian: Ulkus u gastrointestinalnom traktu (nepoznato)
English: Other reactions with a higher frequency seen in patients over 65 were grade 3-4 leucopenia and thrombocytopenia (NCI-CTCAE v.3); and all grade neutropenia, diarrhoea, nausea, headache and fatigue as compared to those aged ≤ 65 years when treated with bevacizumab (see sections 4.4 and 4.8 under Thromboembolism).
Croatian: Ostale nuspojave liječenja bevacizumabom zabilježene češće u bolesnika starijih od 65 godina u usporedbi s bolesnicima u dobi od ≤ 65 godina bile su leukopenija i trombocitopenija stupnja 3-4 (NCI-CTCAE v.3) te neutropenija, proljev, mučnina, glavobolja i umor bilo kojeg stupnja (vidjeti dijelove 4.4 i 4.8, pod Tromboembolija).
English: Severe reactions are defined as adverse events with at least a 2% difference compared to the control arm in clinical studies for NCI-CTCAE grade 3-5 reactions.
Croatian: Teške nuspojave su definirane kao štetni događaji stupnja 3-5 prema NCI-CTCAE s razlikom od barem 2% u odnosu na kontrolnu skupinu u kliničkim ispitivanjima.
English: Overall survival results from study GOG-0240 by trial treatment Treatment comparison Other factor
Croatian: Rezultati ukupnog preživljenja za ispitivanje GOG-0240 prema ispitivanom liječenju
English: Compared to patients treated with chemotherapy (paclitaxel, topotecan or PLD) alone in the recurrent platinum-resistant setting, patients who received bevacizumab at a dose of 10 mg/kg every 2 weeks (or 15 mg/kg every 3 weeks if used in combination with 1.25 mg/m2 topotecan on days 1-5 every 3 weeks) in combination with chemotherapy and continued to receive bevacizumab until disease progression or unacceptable toxicity, had a statistically significant improvement in PFS.
Croatian: U usporedbi s bolesnicama koje su zbog recidiva bolesti rezistentnih na platinu liječene samo kemoterapijom (paklitaksel, topotekan ili PLD), bolesnice koje su primale bevacizumab u dozi od 10 mg/kg svaka 2 tjedna (ili 15 mg/kg svaka 3 tjedna ako se radilo o kombinaciji s topotekanom u dozi od 1,25 mg/m2 od 1. do 5. dana svaka 3 tjedna) u kombinaciji s kemoterapijom i nastavile primati bevacizumab do progresije bolesti ili do pojave neprihvatljive toksičnosti imale su statistički značajno poboljšano preživljenje bez progresije bolesti.
English: • runny nose,
Croatian: • curenje iz nosa,
English: Chemotherapy + bevacizumab (n = 227)
Croatian: Kemoterapija + bevacizumab (n = 227)
English: Topotecan + Paclitaxel
Croatian: topotekan + paklitaksel
English: • Superiority of the bevacizumab-containing arms versus the chemotherapy alone arms in the overall comparison was demonstrated in terms of progression-free survival in the ITT population (Table 7).
Croatian: • Superiornost protokola koji su obuhvaćali bevacizumab u odnosu na samu kemoterapiju u cjelovitoj je usporedbi dokazana s obzirom na preživljenje bez progresije bolesti u populaciji bolesnika u kojoj je planirano liječenje (ITT populaciji) (Tablica 7).
English: MVASI is a concentrate for solution for infusion.
Croatian: MVASI je koncentrat za otopinu za infuziju.
English: Congestive heart failurea,b, Supraventricular tachycardia
Croatian: Srčani poremećaji kongestivno zatajenje srcaa,b, supraventrikularna tahikardija
English: Caution should be exercised when treating patients with clinically significant cardiovascular disease such as pre-existing coronary artery disease, or congestive heart failure with bevacizumab.
Croatian: Potreban je oprez kad se bevacizumab primjenjuje u bolesnika s klinički značajnom bolešću srca i krvnih žila, poput postojeće bolesti koronarnih arterija ili kongestivnog zatajenja srca.
English: (16.2 vs. 12.0 months; p = 0.1342)
Croatian: (16,2 naspram 12,0 mjeseci; p = 0,1342)
English: The results of this trial are presented in table 10.
Croatian: Rezultati ovog ispitivanja prikazani su u Tablici 10.
English: MVASI is also used for the treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Croatian: MVASI se koristi i za liječenje odraslih bolesnica s uznapredovalim epitelnim rakom jajnika, rakom jajovoda ili primarnim peritonealnim rakom.
English: • hole in the gall bladder (symptoms and signs may include abdominal pain, fever, and nausea/vomiting),
Croatian: • napuknuće žučnog mjehura (simptomi i znakovi mogu uključivati bol u trbuhu, vrućicu te mučninu i povraćanje),
English: Aneurysms and artery dissections (see section 4.8)
Croatian: Aneurizme i disekcije arterije (vidjeti dio 4.8)
English: Dose reduction of IFN alfa-2a did not appear to affect the efficacy of the combination of bevacizumab and IFN alfa-2a based on PFS event free rates over time, as shown by a subgroup analysis.
Croatian: Analiza podskupina pokazala je da smanjenje doze IFN alfa-2a nije utjecalo na djelotvornost kombinacije lijeka bevacizumab i IFN alfa-2a, sudeći po udjelima preživljenja bez progresije bolesti u promatranom vremenu.
English: This study was designed as an open-label, randomised, two-arm phase III evaluation of bevacizumab plus chemotherapy (CT + BV) versus chemotherapy alone (CT).
Croatian: Ispitivanje je osmišljeno kao otvoreno, randomizirano ispitivanje faze III u dvije skupine, u kojem se ocjenjivala primjena bevacizumaba i kemoterapije (KT+BV) naspram primjene samo kemoterapije (KT).
English: Trial E2100 was an open-label, randomised, active-controlled, multicentre clinical trial evaluating bevacizumab in combination with paclitaxel for locally recurrent or metastatic breast cancer in patients who had not previously received chemotherapy for locally recurrent and metastatic disease.
Croatian: Ispitivanje E2100 bilo je otvoreno, randomizirano, aktivno kontrolirano multicentrično kliničko ispitivanje u kojemu se ispitivala primjena bevacizumaba u kombinaciji s paklitakselom u liječenju lokalno recidivirajućeg ili metastatskog karcinoma dojke u bolesnika koji prethodno nisu primali kemoterapiju za lokalno recidivirajuću ili metastatsku bolest.
English: No bevacizumab
Croatian: bez bevacizumaba
English: Each vial contains 100 mg bevacizumab in 4 mL of solution or 400 mg bevacizumab in 16 mL of solution.
Croatian: Jedna bočica sadrži 100 mg bevacizumaba u 4 ml otopine ili 400 mg bevacizumaba u 16 ml otopine.
English: • a blood clot in your arteries,
Croatian: • u slučaju krvnog ugruška u arterijama,
English: In a randomised phase II study (BO25041) a total of 121 patients aged ≥ 3 years to < 18 years with newly diagnosed supratentorial or infratentorial cerebellar or peduncular high-grade glioma (HGG) were treated with post-operative radiation therapy (RT) and adjuvant temozolomide (T) with and without bevacizumab: 10 mg/kg every 2 weeks IV.
Croatian: U randomiziranom ispitivanju faze II (BO25041) ukupno je 121 bolesnik u dobi od ≥ 3 godine do < 18 godina s novodijagnosticiranim supratentorijalnim ili infratentorijalnim cerebelarnim ili pedunkularnim gliomom visokog stupnja bio liječen poslijeoperacijskom radioterapijom (RT) i adjuvantnim temozolomidom (T) u kombinaciji s bevacizumabom i bez njega: 10 mg/kg svaka 2 tjedna intravenski.
English: Increased rates of severe neutropenia, febrile neutropenia, or infection with or without severe neutropenia (including some fatalities) have been observed mainly in patients treated with platinumor taxane-based therapies in the treatment of NSCLC and mBC.
Croatian: Povećane stope teške neutropenije, febrilne neutropenije te infekcije praćene teškom neutropenijom ili bez nje (s nekoliko smrtnih ishoda) opažene su većinom u bolesnika koji su primali kemoterapiju na bazi platinskog spoja ili taksana u liječenju karcinoma pluća nemalih stanica i metastatskog karcinoma dojke.
English: When used for patients with breast cancer, it will be administered with a chemotherapy medicinal product called paclitaxel.
Croatian: Kada se koristi za bolesnike s rakom dojke, primjenjuje se uz kemoterapiju lijekovima paklitakselom.
English: Median OS (months) Hazard ratio (95% CI) (eCRF)a
Croatian: Medijan OS (mjeseci) Omjer hazarda (95% CI) (eCRF)a
English: Patients treated with bevacizumab have an increased risk of haemorrhage, especially tumourassociated haemorrhage.
Croatian: Bolesnici liječeni bevacizumabom izloženi su povećanom riziku od krvarenja, a osobito krvarenja povezanog s tumorom.
English: Adverse reactions reported in post-marketing setting
Croatian: Tablica 3. Nuspojave prijavljene nakon stavljanja lijeka u promet
English: Objective response rate1
Croatian: Stopa objektivnog odgovora1
English: The study compared the effect of adding bevacizumab to carboplatin and gemcitabine chemotherapy and continuing bevacizumab as a single agent to progression, to carboplatin and gemcitabine alone.
Croatian: U ovom se ispitivanju uspoređivao učinak na progresiju kod dodavanja bevacizumaba kemoterapiji karboplatinom i gemcitabinom i zatim nastavka primjene samo bevacizumaba u odnosu na terapiju samo karboplatinom i gemcitabinom.
English: This phase III clinical trial compared rituximab/cyclophosphamide/doxorubicin/ vincristine/prednisone (R-CHOP) plus bevacizumab to R-CHOP without bevacizumab.
Croatian: U tom je kliničkom ispitivanju faze III uspoređeno liječenje kombinacijom rituksimab/ciklofosfamid/doksorubicin/vinkristin/prednizon (R-CHOP) uz bevacizumab s protokolom R-CHOP bez bevacizumaba.