FrancophonIA/ELRC3.0 huggingface dataset:
English: Tredaptive (2000 mg/40 mg) co-administered with simvastatin when compared with simvastatin alone or Tredaptive (2000 mg/40 mg) alone for 12 weeks, significantly lowered LDL-C (-47.9 %, -37.0 %, -17.0 % respectively), TG (-33.3 %, -14.7 %, -21.6 % respectively), apo B (-41.0 %, -28.8 %, -17.1 % respectively), and TC (-29.6 %, -24.9 %, -9.1 % respectively), as well as LDL-C:HDL-C (-57.1 %, -39.8 %, -31.2 % respectively), non-HDL-C (-45.8 %, -33.4 %, -18.1 % respectively), and TC:HDL-C (-43.0 %, -28.0 %, -24.9 % respectively), and significantly increased HDL-C (27.5 %, 6.0 %, 23.4 % respectively).
Danish: Sammenlignet med simvastatin alene eller Tredaptive (2.000 mg/40 mg) alene i 12 uger sænkede Tredaptive (2.000 mg/40 mg) sammen med simvastatin LDL-C (henholdsvis -47,9 %, -37,0 %, -17,0 %), TG (henholdsvis -33,3 %, -14,7 %,21,6 %), apo B (henholdsvis -41,0 %, -28,8 %, -17,1 %) og TC (henholdsvis -29,6 %, -24,9 %, 9,1 %) samt LDL-C:HDL-C (henholdsvis -57,1 %, -39,8 %, -31,2 %), non-HDL-C (henholdsvis -45,8 %,33,4 %, -18,1 %) og TC:HDL-C (henholdsvis -43,0 %, -28,0 %, -24,9 %) signifikant og øgede HDL-C signifikant (henholdsvis 27,5 %, 6,0 %, 23,4 %).
English: As with other nicotinic acid medicinal products, elevations in fasting glucose (a median increase of approximately 4 mg/dL), and uric acid (mean change from baseline of +14.7 %), and reductions in platelet counts (a mean change from baseline of -14.0 %) were reported in controlled clinical studies with Tredaptive (2,000 mg/40 mg) (see section 4.4).
Danish: Som med andre nicotinsyrepræparater er der i kontrollerede kliniske undersøgelser med Tredaptive (2.000 mg/40 mg) rapporteret om stigninger i fasteglucose (en gennemsnitlig stigning på ca. 4 mg/dl), urinsyre (gennemsnitlig ændring i forhold til baseline på +14,7 %) samt fald i antal blodplader (en gennemsnitlilg ændring i forhold til baseline på -14,0 %) (se pkt.
English: Tredaptive is used in addition to diet and exercise in adult patients with primary hypercholesterolaemia or mixed dyslipidaemia:
Danish: Tredaptive bruges som tillæg til diæt og motion hos voksne patienter med primær hyperkolesterolæmi eller blandet dyslipidæmi (dvs. ændringer i blodets indhold af fedtstoffer):
English: Luxembourg/Luxemburg MSD Belgium BVBA/SPRL Tél/Tel: 0800 38 693 (+32 (0)27766211) dpoc_belux@merck.com
Danish: Luxembourg/Luxemburg MSD Belgium BVBA/SPRL Tél: 0800 38 693 (+32 (0)27766211) dpoc_belux@merck.com
English: Hepatic insufficiency Tredaptive: Use in patients with hepatic insufficiency has not been studied.
Danish: Leverinsufficiens Tredaptive: Anvendelse til patienter med leverinsufficiens er ikke undersøgt.
English: Therefore, patients switching from immediate-release nicotinic acid to Tredaptive should be initiated at the 1,000 mg/20 mg dose.
Danish: Patienter, der skifter fra nicotinsyre med umiddelbar udløsning til Tredaptive, bør derfor starte med 1.000 mg/20 mg.
English: In an interim analysis of an ongoing clinical outcome study, an independent safety monitoring committee identified a higher than expected incidence of myopathy in Chinese patients taking Tredaptive and simvastatin 40 mg.
Danish: I en interimanalyse af en igangværende outcome-undersøgelse identificerede en uafhængig sikkerhedsmonitoreringskomité en højere incidens af myopati end forventet hos kinesiske patienter, der tog Tredaptive og simvastatin 40 mg. Der bør derfor udvises forsigtighed, når kinesiske patienter behandles med Tredaptive sammen med simvastatin eller ezetimibe/simvastatin (især ved simvastatindoser på 40 mg eller derover).
English: After 4 weeks, your doctor may raise your dose of
Danish: Efter 4 uger vil lægen måske hæve dosis til to tabletter om dagen.
English: Tredaptive contains lactose.
Danish: Tredaptive indeholder lactose.
English: • To lower your chance of flushing, avoid drinking alcohol or hot drinks or eating spicy foods near the time you take your dose of Tredaptive.
Danish: • For at mindske risikoen for rødmen bør De undgå at drikke alkohol eller varme drikke og at spise krydret mad tæt på det tidspunkt, hvor De tager Tredaptive.
English: How Tredaptive Works
Danish: Sådan virker Tredaptive
English: Aluminium/Aluminium blister with push-through lidding in pack sizes of 14, 28, 56, 168 modified-release tablets and 32 x 1 modified-release tablets in perforated unit dose blister.
Danish: Aluminium/aluminium blister med push-through folie i pakningsstørrelser à 14, 28, 56, 168 tabletter med modificeret udløsning og 32 x 1 tabletter med modificeret udløsning i perforeret enkeltdosisblister.
English: Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
Danish: Brug af anden medicin sammen med Tredaptive Fortæl altid lægen eller på apoteket, hvis De bruger anden medicin eller har gjort det for nylig.
English: As with other nicotinic acid medicinal products, Tredaptive (2,000 mg/40 mg) was associated with small increases in uric acid levels (see section 4.8).
Danish: Som med andre nicotinsyrepræparater er Tredaptive (2.000 mg/40 mg) blevet forbundet med små stigninger i urinsyrekoncentrationen (se pkt.
English: Use of Tredaptive in patients with hepatic or renal insufficiency has not been studied.
Danish: Anvendelse af Tredaptive er ikke undersøgt hos patienter med lever- eller nyreinsufficiens.
English: How to take Tredaptive
Danish: Sådan skal De tage Tredaptive
English: Tredaptive 1,000 mg/20 mg modified-release tablets nicotinic acid/laropiprant
Danish: Tredaptive 1.000 mg/20 mg tabletter med modificeret udløsning nicotinsyre/laropiprant
English: Those patients switching from 2,000 mg or more of prolonged-release nicotinic acid can initiate Tredaptive at the 2,000 mg/40 mg dose.
Danish: Patienter, som skifter fra 2.000 mg eller mere af et nicotinsyredepotpræparat, kan starte behandling med Tredaptive med en dosis på 2.000 mg/40 mg.
English: In a multicentre, double-blind, 12-week factorial study, Tredaptive 1,000 mg/20 mg co-administered with simvastatin, when compared with simvastatin alone or Tredaptive 1,000 mg/20 mg alone, for 4 weeks, significantly lowered LDL-C (-44.2 %, -37.4 %, -8.2 % respectively), TG (-25.8 %, -15.7 %, -18.7 % respectively), TC (-27.9 %, -25.8 %, -4.9 % respectively) and significantly increased HDL-C (19.2 %, 4.2 %, 12.5 % respectively).
Danish: I en multicenter, dobbeltblindet 12-ugers faktoriel undersøgelse reducerede Tredaptive 1.000 mg/20 mg og simvastatin signifikant LDL-C (henholdsvis -44,2 %, -37,4 % og -8,2 %), TG (henholdsvis -25,8 %, -15,7 % og -18,7 %), TC (henholdsvis -27,9 %, -25,8 % og -4,9 %), når det blev sammenlignet med simvastatin alene eller Tredaptive 1.000 mg/20 alene i 4 uger.
English: What Tredaptive contains
Danish: Tredaptive indeholder:
English: As with other nicotinic acid medicinal products, Tredaptive (2,000 mg/40 mg) was associated with small reductions in platelet count (see section 4.8).
Danish: Som med andre nicotinsyrepræparater er Tredaptive (2.000 mg/40 mg) blevet forbundet med små reduktioner i antallet af blodplader (se pkt.
English: For patients switching from immediate-release nicotinic acid to Tredaptive, therapy should be initiated at the 1,000 mg/20 mg dose and advanced to the 2,000 mg/40 mg maintenance dose after four weeks.
Danish: Patienter, der skifter fra nicotinsyre med umiddelbar udløsning til Tredaptive, bør starte behandling med 1.000 mg/20 mg og overgå til en vedligeholdelsesdosis på 2.000 mg/40 mg efter fire uger.
English: In a multicentre, double-blind, 24-week placebo-controlled study, patients taking Tredaptive (2,000 mg/40 mg) with or without a statin, when compared to placebo, had significantly decreased LDL-C (-18.9 % vs. -0.5 %), TG (-21.7 % vs. 3.6 %), LDL-C:HDL-C (-28.9 % vs. 2.3 %), non-HDL-C (-19.0 % vs. 0.8 %), apo B (-16.4 % vs. 2.5 %), TC (-9.2 % vs. -0.6 %), Lp(a) (-17.6 % vs. 1.1 %), and TC:HDL-C (-21.2 % vs. 1.9 %) and also had significantly increased HDL-C (18.8 % vs. -1.2 %), and apo A-I (11.2 % vs. 4.3 %) as measured by percent change from baseline.
Danish: I en multicenter, dobbeltblindet, 24-ugers placebokontrolleret undersøgelse havde de patienter, der tager Tredaptive (2.000 mg/40 mg) med eller uden statin, i sammenligning med placebo, signifikant nedsat LDL-C (-18,9 % versus -0,5 %), TG (-21,7 % versus 3,6 %), LDL-C:HDL-C (-28,9 % versus 2,3 %), non-HDL-C (-19,0 % versus 0,8 %) apo-B (-16,4 % versus 2,5 %), TC (-9,2 % versus -0,6 %),
English: Safety and effectiveness of Tredaptive in paediatric patients under the age of 18 years have not been established.
Danish: Tredaptive bør ikke anvendes til pædiatriske patienter under 18 år p.g.a. manglende dokumentation for sikkerhed og virkning.
English: What Tredaptive is and what it is used for What you need to know before you take Tredaptive How to take Tredaptive
Danish: Det skal De vide, før De begynder at tage Tredaptive Sådan skal De tage Tredaptive Bivirkninger
English: NAME OF THE MEDICINAL PRODUCT Tredaptive 1,000 mg/20 mg modified-release tablets Nicotinic acid/laropiprant
Danish: Tredaptive 1.000 mg/20 mg tabletter med modificeret udløsning Nicotinsyre/laropiprant
English: Merck Sharp & Dohme Cyprus Limited Tel: +8007 4433 (+356 99917558) malta_info@merck.com
Danish: Tel: 8007 4433 (+356 99917558) malta_info@merck.com
English: If you take more Tredaptive than you should
Danish: Hvis De har taget for meget Tredaptive
English: flushing, headache, pruritus (itching), nausea, dizziness, vomiting, diarrhoea, abdominal pain/discomfort, and back pain.
Danish: • I forbindelse med overdosis har man set følgende bivirkninger: Rødmen, hovedpine, kløe, kvalme, svimmelhed, opkastning, diarré, mavesmerter/mavegener samt smerter i ryggen.
English: EU/1/08/459/014 32 x 1 modified-release tablets
Danish: EU/1/08/459/009 14 tabletter med modificeret udløsning EU/1/08/459/010 28 tabletter med modificeret udløsning EU/1/08/459/011 56 tabletter med modificeret udløsning EU/1/08/459/013 168 tabletter med modificeret udløsning EU/1/08/459/014 32 x 1 tabletter med modificeret udløsning
English: Merck Sharp & Dohme Ltd.
Danish: Merck Sharp & Dohme Cyprus Limited
English: These signs resolved without treatment.
Danish: Disse tegn forsvandt uden behandling.
English: See also point 4.4.
Danish: Se afsnit 4.4.
English: The actuator can be re-used.
Danish: Aktivatoren kan genbruges.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 10/07/2007
Danish: DATO FOR FØRSTE TILLADELSE/FORNYELSE AF TILLADELSEN Dato for første tilladelse: 10/07/2007
English: Special warnings:
Danish: Særlige advarsler:
English: The metabolism of deslorelin is rapid.
Danish: Deslorelins metabolisme er hurtig.
English: BATCH NUMBER Batch {number}
Danish: BATCHNUMMER Batch{nummer}
English: The treated hobs may remain infertile up to four years.
Danish: Behandlede hanner kan forblive infertile i op til fire år.
English: Date of latest renewal: 17/05/2017
Danish: Dato for fornyelse: 17/05/2017
English: Ferrets: There is no information available in ferrets concerning overdose.
Danish: Ildere: Der er ikke tilgængelig information for ildere vedrørende overdosering.
English: Avoid injection of the implant into fat, as release of the active substance might be impaired in areas of low vascularisation.
Danish: Undgå injektion af implantatet i fedt, da frigivelse af den aktive substans kan blive forringet i områder med lav vaskularisering.
English: Hydrogenated palm oil Lecithin
Danish: Hydreret palmeolie Lecithin
English: The substance can be directly measured in the plasma up to approximately 2.5 months post implantation.
Danish: Stoffet kan måles direkte i plasma op til ca. 2,5 måneder efter implantation.
English: Another GnRH analogue has been shown to be foetotoxic in laboratory animals.
Danish: Det er blevet påvist, at en anden GnRH-analog er føtotoksisk hos laboratoriedyr.
English: Not all parameters of sexual activity have been tested specifically (seborrhoea, urine marking and aggressiveness).
Danish: Ikke alle parametre for seksuel aktivitet er testet specifikt (seborré, urinmærkning og aggressivitet).
English: Levels of testosterone remain below 0.1 ng/ml for at least 16 months.
Danish: Testosteronniveau forbliver under 0,1 ng/ml i mindst 16 måneder.
English: Lift the loose skin between the shoulder blades.
Danish: Løft det løse skind mellem skulderbladene.
English: Do not use after the expiry date which is stated on the carton.
Danish: Må ikke anvendes efter den udløbsdato, som er angivet på æsken efter EXP.
English: 2 implants preloaded in implanters + 1 actuator 5 implants preloaded in implanters + 1 actuator
Danish: 2 implantater på forhånd fyldt i implantatorer + 1 aktivator 5 implantater på forhånd fyldt i implantatorer + 1 aktivator
English: Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Danish: Yderligere information om dette lægemiddel er tilgængelig på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu
English: However, should it be necessary to end treatment, implants may be surgically removed by a veterinarian.
Danish: Skulle det imidlertid blive nødvendigt at afslutte behandlingen, kan en dyrlæge fjerne implantaterne kirurgisk.
English: This suppression results in the failure of treated animals to synthesise and/or release follicle stimulating hormone (FSH) and luteinising hormone (LH), the hormones responsible for the maintenance of fertility.
Danish: Denne suppression resulterer i en manglende evne hos de behandlede dyr til at syntetisere og/eller frigive follikelstimulerende hormon (FSH) og luteiniserende hormon (LH); hormonerne, der er ansvarlige for vedligeholdelsen af drægtighed.
English: Tissue glue is recommended to close the site of administration if required.
Danish: Vævslim anbefales til at lukke administrationsstedet om nødvendigt.
English: White to pale yellow cylindrical implant.
Danish: Hvidt til bleggult cylindrisk implantat.
English: If lack of treatment efficacy is suspected, then the dog's implant (e.g. presence) should be checked.
Danish: Ved mistanke om manglende behandlingseffekt, skal hundens implantat kontrolleres (f.eks. tilstedeværelse).
English: Implants may be located using ultrasound.
Danish: Implantater kan lokaliseres ved hjælp af ultralyd.
English: A short transient increase in plasma testosterone may be seen immediately after implantation.
Danish: En kort forbigående forøgelse af plasmatestosteron kan ses umiddelbart efter implantationen.
English: Pregnant women should not administer the veterinary medicinal product.
Danish: Gravide kvinder bør ikke indgive veterinærlægemidlet.
English: If the hair is long, a small area may be clipped, if required.
Danish: Hvis håret er langt, kan et lille område om nødvendigt klippes.
English: If the hair is long, a small area should be clipped, if required.
Danish: Hvis håret er langt, skal et lille område om nødvendigt klippes.
English: Specific studies to evaluate the effect of deslorelin when administered during pregnancy have not been conducted.
Danish: Der er ikke gennemført specifikke forsøg med henblik på at vurdere virkningen af deslorelin, når det indgives under graviditet.
English: Each pre-loaded implanter is packaged in a sealed foil pouch, which is subsequently sterilised.
Danish: Hver fyldt implantator er pakket i en forseglet foliepose, som derefter bliver steriliseret.
English: It may be possible to palpate the implant in situ.
Danish: Man kan muligvis føle implantatet in situ.
English: The GnRH agonist, deslorelin, acts by suppressing the function of the pituitary-gonadal axis when applied in a low, continuous dose.
Danish: GnRH-agonisten, deslorelin, virker ved at supprimere funktionen af hypofyse-gonade-aksen, når den anvendes i en lav kontinuerlig dosering.
English: Data demonstrate that treatment with the veterinary medicinal product will reduce the libido of the dog.
Danish: Der er data, der viser, at behandling med veterinærlægemidlet reducerer hundens libido.
English: Examine the syringe and needle to ascertain that the implant has not remained within the syringe or needle, and that the spacer is visible.
Danish: Undersøg sprøjten og kanylen for at sikre, at implantatet ikke er blevet tilbage i sprøjten eller kanylen, og at afstandsstykket er synligt.
English: PHARMACEUTICAL PARTICULARS 6.1 List of excipients Hydrogenated palm oil Lecithin
Danish: FARMACEUTISKE OPLYSNINGER 6.1 Fortegnelse over hjælpestoffer Hydreret palmeolie
English: In very rare cases (< 0.01 %) the temporary infertility may last more than 18 months.
Danish: I meget sjældne tilfælde (< 0.01 %) kan den midlertidige infertilitet vare i mere end 18 måneder.
English: Treatment in ferrets should be initiated at the beginning of the breeding season.
Danish: Behandling af ildere bør indledes i starten af avlssæsonen.
English: Press the skin at the insertion site as the needle is withdrawn, and maintain pressure for 30 seconds.
Danish: Tryk på huden på indføringsstedet, medens kanylen trækkes tilbage og oprethold trykket i 30 sekunder.
English: In very rare cases, a transient behavioural change has been reported with the development of aggression (see section 4.4).
Danish: I meget sjældne tilfælde har der været rapporteret om forbigående adfærdsændring med udvikling af aggression (se afsnit 4.4).
English: In both of these circumstances a replacement implant should be administered.
Danish: I begge tilfælde bør et erstatningsimplantat indgives.
English: Deslorelin (as deslorelin acetate)
Danish: Deslorelin (som deslorelinacetat)
English: Remove Luer Lock cap from the implanter.
Danish: Fjern luer-lock-hætten fra implantatoren.
English: Infertility is achieved from 8 weeks up to at least 12 months after initial treatment.
Danish: Infertilitet opnås fra 8 uger op til mindst 12 måneder efter første behandling.
English: Infertility is achieved from 6 weeks up to at least 6 months after initial treatment.
Danish: Infertilitet opnås fra 6 uger op til mindst 6 måneder efter første behandling.
English: In very rare cases the temporary infertility may last more than 18 months.
Danish: I meget sjældne tilfælde kan den midlertidige infertilitet vare i mere end 18 måneder.
English: Only testosterone levels (i.e. an established surrogate marker of fertility) could definitely confirm a lack of efficacy of the treatment.
Danish: Kun testosteronniveauer (dvs. en anerkendt surrogatmarkør for fertilitet) kan med sikkerhed verificere manglende forventet effekt.
English: PHARMACEUTICAL FORM Implant
Danish: LÆGEMIDDELFORM Implantat
English: The biocompatible implant does not require removal.
Danish: Det er ikke nødvendigt at fjerne det biokompatible implantat.
English: DATE ON WHICH THE PACKAGE LEAFLET WAS LAST APPROVED Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Danish: DATO FOR SENESTE GODKENDELSE AF INDLÆGSSEDLEN Yderligere information om dette veterinærlægemiddel er tilgængelig på Det Europæiske Lægemiddelagenturs hjemmeside (http://www.ema.europa.eu)
English: In 2 out of 30 dogs in the clinical trial infertility was not achieved until approximately 12 weeks after initial treatment, but in most cases these animals were not capable of successfully siring offspring.
Danish: Hos 2 ud af 30 hunde i den kliniske undersøgelse, blev infertilitet først opnået 12 uger efter første behandling, men i de fleste tilfælde var disse hunde ikke i stand til at avle afkom.
English: In very rare cases, a testicle may be able to ascend the inguinal ring.
Danish: I meget sjældne tilfælde kan en testikel vandre op i annulus inguinalis.
English: The veterinary medicinal product should therefore be used prudently in hobs intended for future reproduction.
Danish: Veterinærlægemidlet bør derfor anvendes med forsigtighed til hanner, som senere skal bruges til avl.
English: Surgical or medical castration might have unexpected consequences (i.e. improvement or worsening) on aggressive behaviour.
Danish: Kirurgisk eller kemisk kastration kan have uforudsigelig indflydelse (dvs. forbedring eller forværring) på aggressiv adfærd.
English: 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary Ferrets: There is no information available in ferrets.
Danish: 4.10 Overdosering (symptomer, nødforanstaltninger, modgift), om nødvendigt Ildere: Der er ikke tilgængelig information for ildere.
English: Disinfection of the implantation site should be undertaken prior to implantation to avoid introduction of infection.
Danish: Inden implantationen skal implantationsstedet desinficeres for at undgå infektion.
English: The reversibility of effects and ability of treated hobs to produce offspring subsequently has not been investigated.
Danish: Reversibilitet af effekten og behandlede hanners evne til efterfølgende at producere afkom er ikke undersøgt.
English: In very rare cases, a transient behavioural change has been reported with development of aggression (see “Special warnings”).
Danish: I meget sjældne tilfælde har der været rapporteret om forbigående adfærdsændring med udvikling af aggression (se ”Særlige advarsler”).
English: The ability of dogs to sire offspring following their return to normal plasma testosterone levels, after the administration of the veterinary medicinal product, has not been investigated.
Danish: Hundes evne til at avle afkom efter at være vendt tilbage til normale plasmatestosteronniveauer efter indgift af veterinærlægemidlet er ikke blevet undersøgt.
English: One out of 75 dogs treated with the veterinary medicinal product during clinical trials mated and tied with a bitch on heat within six months of implantation, but this did not result in pregnancy.
Danish: En ud af 75 hunde, der blev behandlet med præparatet i kliniske forsøg parrede sig og bandt sig til en tæve i løbetid inden for 6 måneder efter implantation, men dette resulterede ikke i drægtighed.
English: It is therefore recommended that ferrets should be allowed to reach puberty before treatment with the veterinary medicinal product is initiated.
Danish: Det anbefales derfor, at man skal lade ildere nå puberteten, før de behandles med veterinærlægemidlet.
English: It is recommended that the product should be administered under general anaesthesia in ferrets.
Danish: Det anbefales at veterinærlægemidlet administreres til ildere under generel anæstesi.
English: In ferrets: Transient moderate swelling, pruritus and erythema at the implant site were commonly observed during clinical studies.
Danish: Hos ildere: Forbigående moderat hævelse, pruritus og erythem på implantationsstedet var almindeligt forekommende under de kliniske undersøgelser.
English: Infertility (suppression of spermatogenesis, reduced testis size, levels of testosterone below 0.1 ng/ml, and suppression of musky odor) is achieved between 5 weeks and 14 weeks after initial treatment under laboratory conditions.
Danish: Infertilitet (suppression af spermatogenese, reduceret testikelstørrelse, testosteronniveau under 0,1 ng/ml og suppression af moskusagtig lugt) opnås mellem 5 uger og 14 uger efter første behandling i laboratorieomgivelser.
English: Dogs and ferrets:
Danish: Hunde og ildere:
English: Should a treated dog mate with a bitch between 6 weeks and 6 months after treatment, appropriate measures should be taken to rule out the risk of pregnancy.
Danish: Hvis en behandlet hund parrer sig med en tæve mellem 6 uger og 6 måneder efter behandling, bør der tages passende forholdsregler for at udelukke risikoen for drægtighed.
English: Select the implant site by locating the area of the back midway between the shoulder blades.
Danish: Vælg implantationsstedet ved at lokalisere området på ryggen midt mellem skulderbladene.
English: Measurement of plasma concentrations of testosterone has demonstrated the persistent pharmacological effect of the continuing presence of deslorelin in the circulation for at least six months following administration of the veterinary medicinal product.
Danish: Målinger af plasmatestosteronkoncentrationer har påvist den vedvarende farmakologiske virkning af den kontinuerlige tilstedeværelse af deslorelin i kredsløbet i mindst seks måneder efter indgift af præparatet.