FrancophonIA/ELRC3.0 huggingface dataset:
English: Each pack contains 20 film-coated tablets (2 blisters of 10 tablets each) or 40 film-coated tablets (4 blisters of 10 tablets each), or 60 film-coated tablets (6 blisters of 10 tablets each).
Slovenian: Vsako pakiranje vsebuje 20 filmsko obloženih tablet (2 pretisna omota po 10 tablet) ali 40 filmsko obloženih tablet (4 pretisne omote po 10 tablet) ali 60 filmsko obloženih tablet (6 pretisnih omotov po 10 tablet).
English: Patients with renal impairment should be monitored closely when being treated with Lonsurf; patients with moderate renal impairment should be more frequently monitored for haematological toxicities.
Slovenian: Bolnike z ledvično okvaro je potrebno med zdravljenjem z zdravilom Lonsurf skrbno spremljati; bolnike z zmerno ledvično okvaro je treba zaradi hematološke toksičnosti bolj pogosto spremljati.
English: It is currently unknown whether Lonsurf may reduce the effectiveness of hormonal contraceptives, and therefore women using hormonal contraceptives should add a barrier contraceptive method.
Slovenian: Trenutno ni znano, ali zdravilo Lonsurf lahko zmanjša učinkovitost hormonskih kontraceptivov, zato morajo ženske, ki uporabljajo hormonsko kontracepcijo, dodatno uporabiti tudi pregradno metodo kontracepcije.
English: Post-marketing experience in patients with unresectable advanced or recurrent colorectal cancer
Slovenian: Izkušnje po začetku trženja zdravila pri bolnikih z neoperabilnim napredovalim ali ponovljenim kolorektalnim rakom
English: Other minor metabolites, 5-carboxyuracil and 5-carboxy-2'-deoxyuridine, were detected, but those levels in plasma and urine were at low or trace levels.
Slovenian: Zaznali so tudi druge manj pomembne presnovke, 5-karboksiuracil in 5-karboksi-2'-deoksiuridin, a so bile njihove vrednosti v plazmi in urinu nizke ali so se pojavljali le v sledovih.
English: • increased number of white blood cells called monocytes
Slovenian: • zvišanje števila belih krvnih celic imenovanih monociti
English: In particular tell your doctor or pharmacist if you are taking medicines used for treatment of HIV, such as zidovudine.
Slovenian: Svojega zdravnika ali farmacevta morate še posebej obvestiti, če jemljete zdravila za zdravljenje okužbe z virusom HIV, kot je zidovudin.
English: • low or high blood pressure
Slovenian: • nizek ali visok krvni tlak
English: There is limited data on Lonsurf in Black/African American patients but there is no biological rationale to expect any difference between this subgroup and the overall population.
Slovenian: O uporabi zdravila Lonsurf pri bolnikih črne rase je na voljo malo podatkov, vendar ni bioloških razlogov, na podlagi katerih bi lahko sklepali, da obstajajo razlike med to podskupino in celotno populacijo.
English: All changes, i.e., leukopenia, anaemia, bone marrow hypoplasia, atrophic changes in the lymphatic and haematopoietic tissues and the gastrointestinal tract, were reversible within 9 weeks of drug withdrawal.
Slovenian: Vse spremembe, to so levkopenija, anemija, hipoplazija kostnega mozga, atrofične spremembe v limfatičnih in hematopoetskih tkivih ter gastrointestinalnem traktu, so bile reverzibilne v 9 tednih po ukinitvi zdravila.
English: If you are pregnant or breast-feeding, or if you think you might be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo.
English: Serum albumin was found to significantly affect trifluridine clearance, with a negative correlation.
Slovenian: Ugotovili so, da serumski albumin značilno vpliva na očistek trifluridina, in sicer z negativno povezanostjo.
English: The efficacy and safety of Lonsurf in metastatic colorectal cancer was compared between a high exposure group (>median) and a low-exposure group (≤median) based on the median AUC value of trifluridine.
Slovenian: Učinkovitost in varnost zdravila Lonsurf pri metastatskem kolorektalnem raku so primerjali med skupino z veliko izpostavljenostjo (> mediana) in skupino z majhno izpostavljenostjo (≤ mediana) na osnovi mediane vrednosti AUC trifluridina.
English: Les Laboratoires Servier 50 rue Carnot 92284 Suresnes Cedex France
Slovenian: Les Laboratoires Servier 50, rue Carnot 92284 Suresnes cedex Francija
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, z odsotnostjo encima laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: • vision troubles as blurred vision, double vision, decreased vision, cataracts
Slovenian: • težave z vidom, kot so zamegljen vid, dvojni vid, zmanjšan vid, katarakta
English: If you or your partner becomes pregnant during this time, you must talk to your doctor or pharmacist straight away.
Slovenian: Če med tem časom vi ali vaša partnerica zanosita, se morate takoj posvetovati z zdravnikom ali farmacevtom.
English: The influence of gastrectomy on PK parameters was not able to be examined in the population PK analysis because there were few patients who had undergone gastrectomy (1% of overall).
Slovenian: Vpliva gastrektomije na farmakokinetične parametre v populacijski farmakokinetični analizi ni bilo mogoče ovrednotiti, ker je bilo le malo bolnikov po gastrektomiji (1 % vseh bolnikov).
English: It is unknown whether Lonsurf may reduce the effectiveness of hormonal contraceptives.
Slovenian: Ni znano, ali lahko zdravilo Lonsurf zmanjša učinkovitost hormonskih kontraceptivov.
English: • Take within 1 hour after your morning and evening meal.
Slovenian: • Zdravilo vzemite največ 1 uro po jutranjem in večernem obroku.
English: Eighteen percent (18%, N = 144) of all randomised patients received regorafenib prior to randomisation.
Slovenian: Osemnajst odstotkov (18 %, N = 144) vseh randomiziranih bolnikov je pred randomizacijo prejemalo regorafenib.
English: The incidences of Grade ≥3 neutropenia were higher in the high trifluridine AUC group (47.8%) compared with the low-trifluridine AUC group (30.4%).
Slovenian: Pojavnost nevtropenije ≥ 3. stopnje je bila večja v skupini z večjim AUC trifluridina (47,8 %) kot v skupini z manjšim AUC trifluridina (30,4 %).
English: Medical management of an overdose should include customary therapeutic and supportive medical intervention aimed at correcting the presenting clinical manifestations and preventing their possible complications.
Slovenian: Obravnava prevelikega odmerjanja naj vključuje običajne terapevtske in podporne medicinske ukrepe za zmanjševanje klinično izraženih učinkov in preprečevanje njihovih zapletov.
English: • Pulmonary embolism (uncommon): blood clots in lungs.
Slovenian: • pljučna embolija (občasni): krvni strdki v pljučih.
English: Lonsurf is for oral use.
Slovenian: Zdravilo Lonsurf je za peroralno uporabo.
English: No long term studies evaluating the carcinogenic potential of trifluridine/tipiracil hydrochloride in animals have been performed.
Slovenian: Dolgoročnih študij karcinogenega potenciala trifluridina/tipiracilijevega klorida pri živalih niso izvedli.
English: No. at Risk: Lonsurf
Slovenian: Št. ogroženih: Lonsurf
English: The majority of recovered radioactivity was eliminated into urine (55% of the dose) within 24 hours, and the excretion into faeces and expired air was less than 3% for both.
Slovenian: Večina zaznane radioaktivnosti se je v 24 urah izločila v urin (55 % odmerka), izločanje z blatom in izdihanim zrakom je znašalo manj kot 3 % skupaj.
English: If you forget to take Lonsurf
Slovenian: Če ste pozabili vzeti zdravilo Lonsurf
English: Toxicology assessment of trifluridine/tipiracil hydrochloride was performed in rats, dogs and monkeys.
Slovenian: Toksikološka ocena trifluridina/tipiracilijevega klorida je bila izvedena na podganah, psih in opicah.
English: The 2 treatment groups were comparable with respect to demographic and baseline disease characteristics.
Slovenian: Obe zdravljeni skupini sta bili glede na demografske značilnosti in izhodiščne značilnosti bolezni primerljivi.
English: Based upon limited data with a considerable variability, no statistically significant differences were observed in the pharmacokinetics in patients with normal hepatic function versus patients with mild or moderate hepatic impairment.
Slovenian: Na osnovi omejenih podatkov z znatno variabilnostjo niso opazili nobenih statistično značilnih razlik v farmakokinetiki med bolniki z normalnim jetrnim delovanjem in bolniki z blago ali zmerno jetrno okvaro.
English: • Neutropenia (very common), febrile neutropenia (common) and septic shock (uncommon).
Slovenian: • nevtropenija (zelo pogosti), febrilna nevtropenija (pogosti) in septični šok (občasni).
English: • When resuming dosing, decrease the dose level by 5 mg/m2/dose from the previous dose level (Table 4).
Slovenian: • Ob ponovni uvedbi odmerka zmanjšajte raven odmerka za 5 mg/m2/odmerek s prejšnje ravni odmerka (Preglednica 4).
English: • blood test results indicating problems with clotting making you bleed more easily
Slovenian: • izvidi krvnih preiskav, ki kažejo na težave pri strjevanju krvi, zaradi česar lažje nastopi krvavitev
English: • problems passing water (urine retention), loss of bladder control (incontinence)
Slovenian: • težave pri odvajanju urina (zadrževanje urina), nesposobnost zadrževanja urina (inkontinenca)
English: Tell your doctor if you notice any of the following side effects.
Slovenian: Obvestite zdravnika, če opazite kateri koli neželeni učinek.
English: This medicine is not indicated for use in children and adolescents below the age of 18 years.
Slovenian: To zdravilo ni namenjeno za uporabo pri otrocih in mladostnikih, mlajših od 18 let, ker morda pri njih ne deluje ali ni varno.
English: In clinical studies Lonsurf was administered within 1 hour after completion of the morning and evening meals (see section 4.2).
Slovenian: V kliničnih študijah so zdravilo Lonsurf jemali najpozneje 1 uro po zaključku jutranjega in večernega obroka (glejte poglavje
English: • feeling of spinning (vertigo)
Slovenian: • vrtoglavica (vertigo)
English: Trifluridine was shown to be genotoxic in a reverse mutation test in bacteria, a chromosomal aberration test in mammal-cultured cells, and a micronucleus test in mice.
Slovenian: Trifluridin je bil genotoksičen v preskusu povratne mutacije pri bakterijah, preskusu kromosomskih aberacij pri kultiviranih sesalskih celicah in preskusu mikronukleusov pri miših.
English: The DCR (complete response or partial response or stable disease) was significantly higher in patients treated with Lonsurf (44% vs 16%, p < 0.0001).
Slovenian: DCR (popoln odziv ali delni odziv ali stabilna bolezen) je bil značilno višji pri bolnikih, zdravljenih z zdravilom Lonsurf (44 % v primerjavi s 16 %, p < 0,0001).
English: All but 1 patient received bevacizumab, and all but 2 patients with KRAS wild type tumours received panitumumab or cetuximab.
Slovenian: Vsi razen 1 bolnika so prejemali bevacizumab in vsi razen 2 bolnikov z divjim tipom gena KRAS so prejemali panitumumab ali cetuksimab.
English: • increased white blood cells
Slovenian: • zvišanje vrednosti belih krvnih celic
English: Lonsurf contains two different active substances: trifluridine and tipiracil.
Slovenian: Zdravilo Lonsurf vsebuje dve različni zdravilni učinkovini: trifluridin in tipiracil.
English: Pharmacotherapeutic group: antineoplastic agents, antimetabolites, ATC code: L01BC59 Mechanism of action
Slovenian: Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe, antimetaboliti, oznaka ATC: L01BC59
English: Recommended dose modifications
Slovenian: Priporočene spremembe odmerkov
English: In the event of haematological and/or non-haematological toxicities patients should follow the dose interruption, resumption and reduction criteria stated in Table 2, Table 3 and Table 4.
Slovenian: V primeru hematološke in/ali nehematološke toksičnosti je treba pri bolnikih slediti kriterijem za prekinitev, ponovno uvedbo ter zmanjšanje odmerka, ki so navedeni v Preglednicah 2, 3 in 4.
English: Dose escalation is not permitted after it has been reduced.
Slovenian: Potem ko je bil odmerek zmanjšan, povečanje ni dovoljeno.
English: • viral infection
Slovenian: • virusne okužbe
English: Angina pectoris Arrhythmia Palpitations
Slovenian: Srčne bolezni angina pektoris aritmija palpitacije
English: • a reduced number of certain types of white blood cells (neutropenia) which are important for protecting the body against bacterial or fungal infections.
Slovenian: • zmanjšano število določenih tipov belih krvnih celic (nevtropenija), ki so pomembni za obrambo telesa pred okužbami z bakterijami in glivami.
English: • shingles (pain and vesicular rash on skin over nerve tracts affected by nerve inflammation from herpes zoster virus)
Slovenian: • pasovec (bolečina in mehurčkast izpuščaj na koži nad živčnimi potmi, prizadetimi zaradi vnetja živcev z virusom herpes zoster)
English: There is limited data in Lonsurf treated patients aged 75 years and above (87 patients (10%) in pooled data of the RECOURSE and TAGS studies, of which 2 patients were 85 years or older).
Slovenian: Podatkov o bolnikih zdravljenih z zdravilom Lonsurf, starih 75 let in več (87 bolnikov (10 %) po skupnih podatkih iz študij RECOURSE in TAGS, od katerih sta bila 2 bolnika stara 85 let ali več), je malo.
English: The dosage is calculated according to body surface area (BSA) (see Table 1).
Slovenian: Odmerjanje se izračuna na osnovi telesne površine (BSA - Body Surface Area) (glejte Preglednico 1).
English: Therefore, when using antiviral medicinal products that are human thymidine kinase substrates, monitor for possible decreased efficacy of the antiviral medicinal product, and consider switching to an alternative antiviral medicinal product that is not a human thymidine kinase substrate, such as lamivudine, didanosine and abacavir (see section 5.1).
Slovenian: Ob uporabi protivirusnih zdravil, ki so substrati humane timidin-kinaze, morate zaradi potencialne manjše učinkovitosti protivirusnega zdravila bolnika spremljati ter razmisliti o zamenjavi z alternativnim protivirusnim zdravilom, ki ni substrat humane timidin-kinaze, kot je lamivudin, didanozin in abakavir (glejte poglavje 5.1).
English: Lonsurf has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo Lonsurf ima blag vpliv na sposobnost vožnje in upravljanja strojev.
English: OS appeared more favourable in the high AUC group compared to the low AUC group (median OS of 9.3 vs. 8.1 months, respectively).
Slovenian: OS je bil bolj ugoden v skupini z večjim AUC kot pri skupini z majhnim AUC (mediana OS 9,3 meseca v primerjavi z 8,1 meseca).
English: The most common adverse drug reactions (≥ 2%) in patients receiving Lonsurf that resulted in treatment discontinuation, dose reduction, dose delay, or dose interruption were neutropenia, anaemia, leukopenia, fatigue, thrombocytopenia, nausea and diarrhoea.
Slovenian: Najbolj pogosti neželeni učinki (≥ 2%) pri bolnikih, zdravljenih z zdravilom Lonsurf, ki so imeli za posledico prenehanje zdravljenja, zmanjšanje odmerka, zakasnitev odmerka zdravila ali prekinitev, so bili nevtropenija, anemija, levkopenija, utrujenost, trombocitopenija, navzea in diareja.
English: • burning sensation, unpleasant, increased or loss of sense of touch and other non-severe neurological troubles
Slovenian: • pekoč občutek, neprijetna občutljivost za dotik, povečanje ali izguba občutljivosti za dotik in druge manj hude nevrološke težave
English: All AUC groups performed better than placebo throughout the follow-up period.
Slovenian: Obe skupini na osnovi AUC sta bili v času spremljanja bolj zmogljivi kot skupina, ki je prejemala placebo.
English: The primary anticipated complication of an overdose is bone marrow suppression.
Slovenian: Glavni pričakovani zaplet prevelikega odmerjanja je supresija kostnega mozga.
English: Contribution of tipiracil hydrochloride
Slovenian: Prispevek tipiracilijevega klorida
English: What you need to know before you take Lonsurf
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Lonsurf
English: Adverse drug reactions are grouped according to their frequencies.
Slovenian: Neželeni učinki zdravila so razvrščeni po pogostnostih.
English: Such medicinal products, if used concomitantly with Lonsurf, may compete with the effector, trifluridine, for activation via thymidine kinases.
Slovenian: Omenjena zdravila lahko ob sočasni uporabi zdravila Lonsurf tekmujejo z efektorjem trifluridinom za aktivacijo prek timidin-kinaze.
English: • Trifluridine stops the growth of cancer cells.
Slovenian: • Trifluridin zavira rast rakavih celic.
English: • Wash your hands after handling this medicine.
Slovenian: • Po rokovanju s tabletami zdravila si umijte roke.
English: • increased liver enzymes
Slovenian: • zvišanje jetrnih encimov
English: • CTCAE* non-haematologic Grade 3 or Grade 4 adverse reaction; except for Grade 3 nausea and/or vomiting controlled by antiemetic therapy or diarrhoea responsive to antidiarrhoeal medicinal products
Slovenian: • Nehematološki neželeni učinek 3. ali 4. stopnje po CTCAE*; razen navzee in/ali bruhanja 3. stopnje, ki ju lahko nadzorujete z antiemetičnim zdravljenjem, ali diareje, ki se odziva na antidiaroike.
English: Your doctor will be looking out for these side effects in your test results.
Slovenian: Vaš zdravnik bo prek vaših izvidov preiskav spremljal te neželene učinke.
English: • increased lactate dehydrogenase level in your blood
Slovenian: • zvišanje vrednosti laktatne dehidrogenaze v krvi
English: There are no data available on the effects of Lonsurf on human fertility.
Slovenian: Podatkov o vplivu zdravila Lonsurf na plodnost pri ljudeh ni na voljo.
English: Talk to your doctor about whether to switch to a different HIV medicine.
Slovenian: Posvetujte se z zdravnikom, ali je potrebna menjava zdravila za zdravljenje okužbe z virusom HIV.
English: The adverse drug reactions observed from the 533 treated patients with metastatic colorectal cancer in the placebo-controlled Phase III (RECOURSE) clinical trial and the 335 treated patients with metastatic gastric cancer in the placebo-controlled Phase III (TAGS) clinical trial, are shown in Table 5.
Slovenian: Neželeni učinki, o katerih so poročali pri 533 zdravljenih bolnikih z metastatskim kolorektalnim rakomv preskušanju III. faze (RECOURSE), nadzorovanem s placebom, in 335 zdravljenih bolnikih z metastatskim rakom želodca v preskušanju III. faze (TAGS), nadzorovanem s placebom, so navedeni v Preglednici 5.
English: Number of deaths, N (%) Median OS (months)a [95% CI]b
Slovenian: Število smrti, N (%) Mediana OS (meseci)a [95-% CI]b
English: The marketing authorisation holder shall submit the first periodic safety update report for this product within 6 months following authorisation.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora prvi PSUR za to zdravilo predložiti v 6 mesecih po pridobitvi dovoljenja za promet.
English: The increases in the corpus luteum count and implanting embryo count observed in female rats at high doses were not considered adverse (see section 4.6).
Slovenian: Povečanje števila rumenih telesc in števila vsajenih embrijev, ki so ga opazili pri podganjih samicah pri velikih odmerkih, ni bilo ocenjeno kot škodljivo (glejte poglavje 4.6).
English: Do not breast-feed if you are taking Lonsurf as it is not known whether Lonsurf passes into the mother's milk.
Slovenian: Med zdravljenjem z zdravilom Lonsurf ne smete dojiti, saj ni znano, ali zdravilo Lonsurf prehaja v materino mleko.
English: Marketing Authorisation Holder Les Laboratoires Servier 50 rue Carnot
Slovenian: Imetnik dovoljenja za promet z zdravilom Les Laboratoires Servier 50, rue Carnot
English: Fatigue, dizziness or malaise may occur during treatment (see section 4.8).
Slovenian: Med zdravljenjem se lahko pojavijo utrujenost, omotica ali splošno slabo počutje (glejte poglavje 4.8).
English: Interruption criteria
Slovenian: Kriterij za prekinitev zdravljenja
English: • The active substances are trifluridine and tipiracil.
Slovenian: • Zdravilni učinkovini sta trifluridin in tipiracil.
English: There is no relevant use of Lonsurf in the paediatric population for the indications of metastatic colorectal cancer and metastatic gastric cancer.
Slovenian: Zdravilo Lonsurf ni namenjeno za uporabo pri pediatrični populaciji za indikaciji metastatskega kolorektalnega raka in metastatskega raka želodca.
English: A maximum of 3 dose reductions are permitted to a minimum dose of 20 mg/m2 twice daily.
Slovenian: Dovoljena so največ 3 zmanjšanja odmerka na najmanjši odmerek 20 mg/m2 dvakrat dnevno.
English: The signs include unusual bruising or bleeding (see section 2).
Slovenian: Znaki vključujejo neobičajne modrice ali krvavitve (glejte poglavje 2);
English: Lonsurf is a type of cancer chemotherapy which belongs to the group of medicines called "cytostatic antimetabolite medicines".
Slovenian: Zdravilo Lonsurf je vrsta kemoterapije za zdravljenje raka, ki spada v skupino zdravil, ki se imenujejo citostatiki (antimetaboliti).
English: It is unknown whether Lonsurf or its metabolites are excreted in human milk.
Slovenian: Ni znano, ali se zdravilo Lonsurf ali njegovi presnovki izločajo v materino mleko.
English: The absorbed trifluridine was metabolised, and excreted into urine as FTY and trifluridine glucuronide isomers.
Slovenian: Absorbirani trifluridin se presnovi in izloči v urin kot FTY in izomere glukuronidov trifluridina.
English: All patients received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.
Slovenian: Vsi bolniki so prej prejemali kemoterapijo na osnovi fluoropirimidina, oksaliplatina in irinotekana.
English: • high blood sugar (hyperglycaemia), increased salt, urea, creatinine and potassium in your blood
Slovenian: • visok krvni sladkor (hiperglikemija), zvišanje vrednosti soli, sečnine, kreatinina in kalija v krvi
English: • abnormal increase or decrease in heart rate
Slovenian: • nenormalno povečanje ali zmanjšanje srčne frekvence
English: Based on the population PK analysis, liver function parameters including alkaline phosphatase (ALP, 36-2322 U/L), aspartate aminotransferase (AST, 11-197 U/L), alanine aminotransferase (ALT, 5-182 U/L) , and total bilirubin (0.17-3.20 mg/dL) were not significant covariates for PK parameters of either trifluridine or tipiracil hydrochloride.
Slovenian: Na podlagi populacijske farmakokinetične analize parametri spremljanja delovanja jeter, vključno z alkalno fosfatazo (AF, 36 - 2322 U/l), aspartat-aminotransferazo (AST, 11 - 197 U/l), alanin-aminotransferazo (ALT, 5 - 182 U/l) in celotnim bilirubinom (0,17 - 3,20 mg/dl), niso bili hkratne spremenljivke farmakokinetičnih parametrov niti trifluridina niti tipiracilijevega klorida.
English: Given that the majority were reported in the context of bone marrow suppression, the patient's condition should be monitored closely, and appropriate measures, such as antimicrobial agents and granulocyte-colony stimulating factor (G-CSF), should be administered as clinically indicated.
Slovenian: O večini so poročali v povezavi s supresijo kostnega mozga, zato morate stanje bolnika pozorno spremljati in uporabiti ustrezne ukrepe, ko so protimikrobna zdravila in granulocitne kolonije stimulirajoči faktor (G-CSF), če je to klinično indicirano.
English: No peri/post-natal developmental toxicity studies have been performed.
Slovenian: Študij toksičnosti na perinatalni in postnatalni razvoj niso izvedli.
English: 50a a At a total daily dose of 50 mg, patients should take 1 x 20 mg/8.19 mg tablet in the morning and 2 x 15 mg/6.14 mg tablets in the evening.
Slovenian: 50a a Pri celotnem dnevnem odmerku 50 mg mora bolnik vzeti eno 20 mg/8,19 mg tableto zjutraj in dve 15 mg/6,14 mg tableti zvečer.