FrancophonIA/ELRC3.0 huggingface dataset:
English: • excessive sleepiness, dizziness, confusion, disorientation, difficulty talking, difficulty walking, muscle stiffness or shaking, weakness, irritability, aggression, anxiety, increase in blood pressure, or convulsions and can lead to unconsciousness.
Danish: • Udpræget søvnighed, svimmelhed, forvirring, desorientering, talebesvær, gangbesvær, muskelstivhed eller rysten, svaghed, irritabilitet, aggression, angst, stigning i blodtryk eller kramper og kan føre til tab af bevidsthed.
English: After repeated IM injections with 150 to 300 mg ZYPADHERA every two weeks, the 10th to 90th percentile of steady-state plasma concentrations of olanzapine were between 4.2 and 73.2 ng/ml.
Danish: Efter gentagne i. m.-injektioner med 150 til 300 mg ZYPADHERA hver anden uge var 10 til 90 percentilen af olanzapins steady state-plasmakoncentration mellem 4,2 og 73,2 ng/ml.
English: Reversible neutropenia, thrombocytopenia, or anaemia developed in a few dogs treated with 8 or 10 mg/kg/day (total olanzapine exposure [AUC] is 12- to 15-fold greater than that of a man given a 12 mg dose).
Danish: Reversibel neutropeni, trombocytopeni eller anæmi udvikledes hos enkelte hunde, som blev behandlet med 8 eller 10 mg/kg/dag (total olanzapin dosis [AUC] var 12-15 gange højere end human dosis på 12 mg).
English: STEP 1: Injecting ZYPADHERA
Danish: TRIN 1: Indsprøjtning af ZYPADHERA
English: An allergic reaction may be recognised as a rash, itching, a swollen face, swollen lips or shortness of breath.
Danish: En allergisk reaktion kan kendes ved udslæt, kløe, hævelse af ansigt og læber eller stakåndethed.
English: Inject the solvent volume into the powder vial.
Danish: Indsprøjt solvensmængden i hætteglasset med pulver.
English: If this happens, contact your doctor or nurse immediately.
Danish: Hvis det sker, skal du straks kontakte din sygeplejerske eller læge.
English: Thromboembolis m (including pulmonary embolism and deep vein thrombosis) (see section 4.4)
Danish: Tromboemboli (inklusive lungeemboli og dyb venetrombose) (se pkt.
English: Other medically significant sequelae of overdose include delirium, convulsion, coma, possible neuroleptic malignant syndrome, respiratory depression, aspiration, hypertension or hypotension, cardiac arrhythmias (< 2% of overdose cases) and cardiopulmonary arrest.
Danish: Andre medicinsk signifikante følgetilstande af overdosering inkluderer delirium, kramper, koma, muligt malignt neuroleptikasyndrom, respirationsbesvær, aspiration, hypertension eller hypotension, hjertearytmi (< 2 % af overdoseringstilfældene) og kardiopulmonært stop.
English: • Vial of solvent for ZYPADHERA
Danish: • Hætteglas med solvens til ZYPADHERA
English: Transient, asymptomatic elevations of hepatic aminotransferases, ALT, AST have been seen commonly, especially in early treatment.
Danish: Forbigående, asymptomatiske forhøjelser af leveraminotransferaser, ALAT og ASAT, er almindeligt forekommende, især initialt i behandlingen.
English: • Patient Information Leaflet
Danish: • Indlægsseddel til patienten
English: Loosen the powder by lightly tapping the vial.
Danish: Løsgør pulveret ved at banke hætteglasset let.
English: 14 Observed for fasting normal levels at baseline (< 1.016 mmol/l) which increased to high (≥ 1.467 mmol/l) and changes in fasting triglycerides from borderline at baseline (≥ 1.016 mmol/l< 1.467 mmol/l) to high (≥ 1.467 mmol/l).
Danish: 14 De observerede normalniveauer ved baseline (< 1,016 mmol/l ved faste) steg til høje niveauer (≥ 1,467 mmol/l), og triglyceridniveauerne ved faste, der lå ved grænsen ved baseline (≥ 1,016 mmol/l - < 1,467 mmol/l), steg til høje (≥ 1,467 mmol/l).
English: Rare cases reported as NMS have also been received in association with oral olanzapine.
Danish: Sjældne tilfælde af mulig NMS er også observeret i forbindelse med oral olanzapin.
English: Visually confirm that the needle is fully engaged into the needle protection sheath.
Danish: Kontroller visuelt, at kanylen er fuldstændig tilkoblet i kanylebeskyttelsesudstyret.
English: • irritability
Danish: • Irritabilitet
English: • One 19-gauge, 38 mm Hypodermic safety needle
Danish: • En 19-gauge, 38 mm Hypodermic sikkerhedskanyle
English: Development or exacerbation of diabetes occasionally associated with ketoacidosis or coma, including some fatal cases (see section 4.4)11
Danish: Udvikling eller forværring af diabetes lejlighedsvist sammen med ketoacidose eller coma, heriblandt dødelige tilfælde (se pkt.
English: If an overdose is suspected, close medical supervision and monitoring should continue until examination indicates that signs and symptoms have resolved (see section 4.4.).
Danish: Hvis der er mistanke om overdosering, bør tæt medicinsk overvågning og monitorering fortsætte, indtil undersøgelser indikerer, at tegn og symptomer er forsvundet (se pkt.
English: Adverse reactions seen with olanzapine The undesirable effects listed below have been observed following administration of olanzapine.
Danish: Bivirkninger set ved olanzapin De bivirkninger, som er nævnt nedenfor, er set efter administration af olanzapin.
English: Most of these patients have developed symptoms of sedation (ranging from mild in severity up to coma) and/or delirium (including confusion, disorientation, agitation, anxiety and other cognitive impairment).
Danish: De fleste af disse patienter udviklede symptomer på sedation (fra mild sedation til koma) og/eller delirium (herunder forvirring, desorientering, ophidselse/uro, angst og anden kognitiv svækkelse).
English: ZYPADHERA is intended for adult patients who are sufficiently stabilised during treatment with oral olanzapine.
Danish: ZYPADHERA er beregnet til voksne patienter, som er tilstrækkeligt stabiliseret med oral olanzapin.
English: Ventricular tachycardia/fibrill ation, sudden death (see section
Danish: Ventrikulær takykardi/ventrike l-flimren, pludselig død (se pkt.
English: This leaflet was last revised in {mmm YYYY}
Danish: Denne indlægsseddel blev senest ændret
English: There was a 3-fold increase in CVAE in patients treated with oral olanzapine compared to patients treated with placebo (1.3% vs. 0.4%, respectively).
Danish: Der var en tre gange så høj forekomst af cerebrovaskulære bivirkninger hos de patienter, som blev behandlet med oral olanzapin, sammenlignet med de patienter, som blev behandlet med placebo (henholdsvis 1,3 % og 0,4 %).
English: The plasma concentrations of olanzapine observed across the dose range of 150mg every 4 weeks to 300mg every 2 weeks illustrate increased systemic olanzapine exposure with increased ZYPADHERA doses.
Danish: Målinger af olanzapins plasmakoncentration i dosisintervallet fra 150 mg hver 4. uge til 300 mg hver 2. uge viser øget systemisk eksponering for olanzapin med øgede ZYPADHERA-doser.
English: The active substance is olanzapine.
Danish: - Aktivt stof: Olanzapin.
English: After each injection you will be observed in your healthcare facility for at least 3 hours for the symptoms listed above.
Danish: Efter hver indsprøjtning vil du blive holdt under observation af din læge eller sygeplejerske i mindst 3 timer for symptomerne nævnt ovenfor.
English: FOR INTRAMUSCULAR USE ONLY.
Danish: KUN TIL INTRAMUSKULÆR ANVENDELSE.
English: • One Hypodermic syringe and safety needle (Hypodermic Device)
Danish: • En Hypodermic sprøjte og sikkerhedskanyle (Hypodermic kit)
English: ZYPADHERA vial strength (mg)
Danish: ZYPADHERA pulver i hætteglas (mg)
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT 210 mg
Danish: INDHOLD ANGIVET SOM VÆGT, VOLUMEN ELLER ANTAL DOSER 210 mg
English: In clinical trials in patients with drug-induced (dopamine agonist) psychosis associated with Parkinson's disease, worsening of Parkinsonian symptomatology and hallucinations were reported very commonly and more frequently than with placebo.
Danish: I kliniske forsøg med patienter med lægemiddelinduceret psykose (dopaminagonist) i forbindelse med Parkinsons sygdom, var hyppigheden af rapporter om forværring af Parkinson symptomatologi og hallucinationer meget almindeligt og oftere end med placebo.
English: Controlled efficacy data in adolescents (ages 13 to 17 years) are limited to short term oral olanzapine studies in schizophrenia (6 weeks) and mania associated with bipolar I disorder (3 weeks), involving less than 200 adolescents.
Danish: Kontrollerede effektdata hos unge (13-17 år) omfatter mindre end 200 unge og er begrænset til kortvarige studier hos patienter med skizofreni (6 uger) og mani i forbindelse med bipolar I-sygdom (3 uger).
English: • confusion
Danish: • Forvirring
English: The effectiveness of ZYPADHERA in the treatment and maintenance treatment of schizophrenia is consistent with the established effectiveness of the oral formulation of olanzapine.
Danish: Virkningen af ZYPADHERA ved behandling og vedligeholdelsesbehandling af skizofreni er i overensstemmelse med den anerkendte virkning af den orale olanzapinformulering.
English: AS THE SHEATH IS PRESSED (Fig. 1), THE NEEDLE IS FIRMLY ENGAGED INTO THE SHEATH (Fig. 2).
Danish: NÅR DER TRYKKES PÅ HYLSTERET (Fig. 1), PRESSES KANYLEN FAST IND I HYLSTERET (Fig. 2).
English: Pneumonia, increased body temperature, lethargy, erythema, visual hallucinations and urinary incontinence were observed commonly.
Danish: Pneumoni, øget legemstemperatur, apati, erytem, synsforstyrrelser og urininkontinens blev observeret almindeligt.
English: The vial is for single use only.
Danish: Hætteglasset er kun til engangsbrug.
English: Haematologic toxicity: Effects on haematology parameters were found in each species, including doserelated reductions in circulating leukocytes in mice and non-specific reductions of circulating leukocytes in rats; however, no evidence of bone marrow cytotoxicity was found.
Danish: Der blev observeret påvirkning af de hæmatologiske parametre i hver dyreart, herunder dosisafhængig reduktion af cirkulerende leukocytter hos mus og ikke-specifik reduktion af cirkulerende leukocytter hos rotter.
English: Other common side effects (may affect up to 1 in 10 people) with ZYPADHERA include sleepiness and injection site pain.
Danish: Andre almindelige bivirkninger (forekommer hos op til 1 ud af 10 patienter) ved ZYPADHERA omfatter søvnighed og smerter på injektionsstedet.
English: Clinical signs and symptoms included symptoms of sedation (ranging from mild in severity up to coma) and/or delirium (including confusion, disorientation, agitation, anxiety and other cognitive impairment).
Danish: De kliniske tegn og symptomer inkluderede symptomer på sedation (fra mild sedation til koma) og/eller delirium (herunder forvirring, desorientering, ophidselse/uro, angst og anden kognitiv svækkelse).
English: In monkeys, single oral doses up to 100 mg/kg resulted in prostration and, at higher doses, semi-consciousness.
Danish: Hos aber medførte orale enkeltdoser på op til 100 mg/kg afkræftelse, og højere doser medførte halvt bevidstløs tilstand.
English: As it exhibits in vitro dopamine antagonism, olanzapine may antagonize the effects of direct and indirect dopamine agonists.
Danish: Da olanzapin udviser in vitro-dopaminantagonisme, kan det hæmme effekten af direkte eller indirekte dopaminagonister.
English: In clinical trials in elderly patients with dementia, olanzapine treatment was associated with a higher incidence of death and cerebrovascular adverse reactions compared to placebo (see also section 4.4).
Danish: I kliniske forsøg med ældre demente patienter blev olanzapinbehandling forbundet med en højere incidens af dødsfald og cerebrovaskulære hændelser sammenlignet med placebo (se pkt.
English: Attach a syringe (if not already attached) to the Luer connection of the device with an easy twisting motion.
Danish: Fastgør med en let vridende bevægelse en sprøjte (hvis ikke allerede fastgjort) til udstyrets Luer-fatning.
English: Following short term treatment (median duration 47 days), weight gain ≥ 7% of baseline body weight was very common (22.2 %), ≥ 15 % was common (4.2 %) and ≥ 25 % was uncommon (0.8 %).
Danish: Efter kortvarig behandling (gennemsnitlig varighed 47 dage) var vægtstigning ≥ 7 % af kropsvægt ved baseline meget almindelig (22,2 %), ≥ 15 % var almindelig (4,2 %) og ≥25 % var ikke almindelig (0,8 %).
English: Maintenance treatment of adult patients with schizophrenia sufficiently stabilised during acute treatment with oral olanzapine.
Danish: Vedligeholdelsesbehandling til voksne patienter med skizofreni, som er tilstrækkelig stabiliseret med oral olanzapin ved akut behandling.
English: Driving and using machines Do not drive or operate machinery for the remainder of the day after each injection.
Danish: Trafik- og arbejdssikkerhed Du må ikke køre eller arbejde med maskiner resten af den dag, du har fået indsprøjtning.
English: Post-injection syndrome
Danish: Beskrivelse af postinjektionssyndrom
English: One carton contains one vial of powder and one vial of solvent, one Hypodermic 3ml syringe with preattached 19-gauge, 38 mm safety needle, one 19-gauge, 38 mm Hypodermic safety needle and two 19gauge, 50 mm Hypodermic safety needles.
Danish: En æske indeholder et hætteglas med pulver og et hætteglas med solvens, en 3 ml Hypodermic sprøjte med fastgjort 19-gauge, 38 mm sikkerhedskanyle, en 19-gauge, 38 mm Hypodermic sikkerhedskanyle og to 19-gauge, 50 mm Hypodermic sikkerhedskanyler.
English: ZYPADHERA is given in doses of 150 mg to 300 mg every 2 weeks or 300 mg to 405 mg every 4 weeks.
Danish: ZYPADHERA gives i doser på 150 mg til 300 mg hver 2. uge eller 300 mg til 405 mg hver 4. uge.
English: The concomitant use of olanzapine with anti-Parkinsonian medicinal products in patients with Parkinson's disease and dementia is not recommended (see section 4.4).
Danish: Samtidig brug af olanzapin med antiparkinson-lægemidler til patienter med Parkinsons sygdom og demente frarådes (se pkt.
English: Fluoxetine (a CYP2D6 inhibitor), single doses of antacid (aluminium, magnesium) or cimetidine have not been found to significantly affect the pharmacokinetics of olanzapine.
Danish: Der er ikke fundet tegn på, at fluoxetin (en CYP2D6-inhibitor), enkeltdoser af antacida (aluminium, magnesium) eller cimetidin påvirker olanzapins farmakokinetik signifikant.
English: If this has happened to you, tell your nurse or doctor.
Danish: Hvis du har oplevet dette, skal du fortælle det til en sygeplejerske eller læge.
English: 3 ml solvent: Type I glass vial.
Danish: 3 ml solvens: Hætteglas af type I-glas.
English: What ZYPADHERA contains
Danish: ZYPADHERA indeholder:
English: Powder and solvent for prolonged release suspension for injection Powder: yellow solid
Danish: Pulver og solvens til depotinjektionsvæske, suspension Pulver: gult tørstof
English: After clinical reassessment dose may be adjusted within the range 150 mg to 300 mg every 2 weeks or 300 to 405 mg every 4 weeks.
Danish: Efter klinisk revurdering kan dosis justeres inden for området 150 mg til 300 mg hver 2. uge eller 300 mg til 450 mg hver 4. uge.
English: Parkinsonism6 Dyskinesia6
Danish: Parkinsonisme6
English: Reconstitute ZYPADHERA powder for prolonged release suspension for injection only with the solvent provided in the pack using standard aseptic techniques for reconstitution of parenteral products.
Danish: Rekonstituer kun ZYPADHERA pulver til depotinjektionsvæske, suspension med det solvens, som er i pakningen under anvendelse af standard aseptisk teknik til rekonstitution af parenterale lægemidler.
English: 13 Following short term treatment (median duration 22 days), weight gain ≥ 7% of baseline body weight (kg) was very common (40.6 %), ≥ 15% of baseline body weight was common (7.1 %) and ≥ 25 % was common (2.5 %).
Danish: 13 Efter kortvarig behandling (gennemsnitlig varighed 22 dage) var vægtstigning ≥ 7 % af legemsvægt (kg) ved baseline meget almindelig (40,6 %), ≥ 15 % af legemsvægt ved baseline var almindelig (7,1 %) og ≥25 % var almindelig (2,5 %).
English: The side effects listed below have been observed when oral olanzapine has been given but may occur following administration of ZYPADHERA.
Danish: De bivirkninger, som er nævnt nedenstående, er blevet set, når olanzapin er givet via munden (oralt), men kan forekomme efter indsprøjtning af ZYPADHERA.
English: Gastrointestinal disorders Mild, transient anticholinergic effects including constipation and dry mouth
Danish: Mave-tarmkanalen Lette forbigående antikolinerge virkninger, herunder forstoppelse og mundtørhed
English: Engage the needle safety device and remove needle from syringe.
Danish: Fastgør sikkerhedskanylens kanylebeskyttelsesudstyr og fjern kanylen fra sprøjten.
English: (Fig. 1 and 2) 8.
Danish: 4.8 og 5.1).
English: Bromobutyl stopper with steel blue colour seal.
Danish: Brombutylprop med stålblå forsegling.
English: In one clinical trial in patients with bipolar mania, valproate combination therapy with olanzapine resulted in an incidence of neutropenia of 4.1%; a potential contributing factor could be high plasma valproate levels.
Danish: I et klinisk forsøg med patienter med bipolar mani resulterede valproat kombinationsterapi med olanzapin i en incidens af neutropeni på 4,1 %.
English: The injection must not be given after the expiry date which is stated on the carton.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på pakningen efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: Investigations Elevated plasma prolactin levels8
Danish: Undersøgelser Forhøjede plasmaprolaktin -niveauer8
English: One carton contains one vial of powder for prolonged release suspension for injection, one vial of 3 ml solvent, one syringe with safety needle, 19 gauge, 38mm, attached and three separate safety needles; one 19 gauge, 38mm needle and two 19 gauge 50mm needles.
Danish: En æske indeholder et hætteglas med pulver til depotinjektionsvæske, suspension, et hætteglas med 3 ml solvens, en sprøjte med fastgjort sikkerhedskanyle, 19-gauge, 38 mm, og tre separate sikkerhedskanyler: én 19-gauge, 38 mm kanyle og to 19 gauge 50 mm kanyler.
English: The frequency terms listed are defined as follows: Very common (≥ 1/10),
Danish: Hyppighederne er defineret som følgende: Meget almindelig (≥1/10), almindelig (≥1/100
English: The solvent excipients are carmellose sodium, mannitol, polysorbate 80, water for injections, hydrochloric acid, sodium hydroxide.
Danish: Solvensens hjælpestoffer er carmellosenatrium, mannitol, polysorbat 80, vand til injektionsvæsker, saltsyre, natriumhydroxid.
English: STEP 2: Determining solvent volume for reconstitution This table provides the amount of solvent required to reconstitute ZYPADHERA powder for prolonged release suspension for injection.
Danish: TRIN 2: Bestemmelse af mængden af solvens til rekonstitution Nedenstående tabel angiver mængden af solvens, som er nødvendigt til at rekonstituere ZYPADHERA pulver til depotinjektionsvæske, suspension.
English: In a Positron Emission Tomography (PET) study in patients treated with ZYPADHERA (300 mg/4 weeks), mean D2 receptor occupancy was 60% or higher at the end of a 6 month period, a level consistent with that found during treatment with oral olanzapine.
Danish: I et forsøg med positron-emissionstomografi (PET) hos patienter, som blev behandlet med ZYPADHERA (300 mg hver 4. uge), var den gennemsnitlige D2-receptorbinding 60 % eller højere ved slutningen af en 6 måneders periode.
English: - Description of post injection syndrome - Recommendation for a 3-hour on-site observation period post injection - Recommendation for informing patients that for the remainder of the day of the injection, they should not drive or operate machinery, should be vigilant for signs and symptoms of a post injection syndrome event, and should be able to obtain assistance if needed - Description of the most common symptoms reported with olanzapine overdose that represent the clinical manifestation in post injection syndrome events - Recommendation for appropriate monitoring until the event resolves if an event should occur
Danish: Anbefaling af en 3-timers observationsperiode på stedet efter injektion Anbefaling af, at patienterne informeres om, at de resten af dagen efter en injektion ikke skal køre motorkøretøj eller betjene maskiner, skal være opmærksomme på tegn og symptomer på et tilfælde af postinjektionssyndrom og skal kunne få hjælp om nødvendigt Beskrivelse af de mest almindelige symptomer rapporteret ved overdosis af olanzapin, som repræsenterer den kliniske manifestation ved tilfælde af postinjektionssyndrom Anbefaling af passende monitorering i tilfælde af at en hændelse skulle opstå, indtil hændelsen er forsvundet
English: Post-injection syndrome reactions have occurred with ZYPADHERA leading to symptoms consistent with olanzapine overdose (see sections 4.2 and 4.4).
Danish: Tilfælde af postinjektionssyndrom er forekommet med ZYPADHERA og har ført til symptomer som ved overdosering med olanzapin (se pkt.
English: ZYPADHERA comes as a powder which your doctor or nurse will make into a suspension that will then be injected into the muscle in your buttock.
Danish: Din læge eller sygeplejerske vil blande det til en suspension, som derpå bliver indsprøjtet i musklen i din endeballe.
English: 15 mg/day
Danish: 15 mg/dag
English: ZYPADHERA is not recommended to be started in patients >75 years (see section 4.4).
Danish: ZYPADHERA frarådes til behandling af patienter >75 år (se pkt.
English: After each injection, patients should be observed in a healthcare facility by appropriately qualified personnel for at least 3 hours for signs and symptoms consistent with olanzapine overdose.
Danish: Efter hver injektion bør patienterne observeres i et sundhedscenter af tilstrækkeligt uddannet personale i mindst 3 timer for tegn og symptomer som ved overdosering med olanzapin.
English: Antipsychotic supplementation is not required at the initiation of ZYPADHERA treatment (see section 4.2).
Danish: Frigivelsen formindskes i løbet af otte til tolv uger Det er ikke nødvendigt med antipsykotisk supplering ved initieringen af behandling med ZYPADHERA (se pkt.4.2).
English: Signs of oral toxicity in rodents were characteristic of potent antipsychotic compounds: hypoactivity, coma, tremors, clonic convulsions, salivation, and depressed weight gain.
Danish: Den observerede orale toksicitet hos gnavere er karakteristisk for potente antipsykotiske lægemiddelstoffer: hypoaktivitet, koma, tremor, kloniske kramper, spytsekretion og hæmmet vægtøgning.
English: What ZYPADHERA is and what it is used for What you need to know before you are given ZYPADHERA How ZYPADHERA is given
Danish: Virkning og anvendelse Det skal du vide før du får ZYPADHERA Sådan bliver du behandlet med ZYPADHERA Bivirkninger
English: • blood clots in the veins (an uncommon side effect that may affect up to 1in 100 people) especially in the legs (symptoms include swelling, pain, and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing.
Danish: • Blodpropper i venerne (en ikke almindelig bivirkning, som forekommer hos op til 1 ud af 100 patienter), særligt i benene (symptomerne omfatter hævelse og smerter i benet samt hudrødmen).
English: Bromobutyl stopper with olive colour seal.
Danish: Brombutylprop med olivengrøn forsegling.
English: Additional signs may include elevated creatine phosphokinase, myoglobinuria
Danish: Yderligere symptomer kan inkludere forhøjet kreatinfosfokinase, myoglobulinuri (rhabdomyolyse) og akut nyresvigt.
English: After reconstitution: 150 mg/ml olanzapine.
Danish: Efter rekonstitution: 150 mg/ml olanzapin.
English: • acute confusion, seizures (epilepsy), coma, a combination of fever, faster breathing, sweating, muscle stiffness, and drowsiness or sleepiness; slower breathing, aspiration, high or low blood pressure, abnormal rhythms of the heart.
Danish: • Akut forvirring, kramper (epileptiske), bevidstløshed, en blanding af feber, hurtigere åndedræt, svedtendens, muskelstivhed og sløvhed eller søvnløshed; langsomt åndedræt, aspiration (som at sluge luft/få noget galt i halsen), højt eller lavt blodtryk, unormal hjerterytme.