FrancophonIA/ELRC3.0 huggingface dataset:
English: Vaccines work by ‘teaching' the immune system (the body's natural defences) how to defend itself against a disease.
Croatian: Cjepiva djeluju „učeći” imunosni sustav (prirodnu obranu tijela) kako da se obrani protiv bolesti.
English: The resulting ‘emulsion' is then injected.
Croatian: Zatim se dobivena „emulzija” ubrizgava.
English: Vaccination should be postponed in subjects with severe fever or an acute (short-lived) infection.
Croatian: Cijepljenje treba odgoditi kod osoba s visokom vrućicom ili akutnom (kratkotrajnom) infekcijom.
English: The CHMP noted that a single dose was able to trigger immunity to a satisfactory level in adults (including the elderly), adolescents and children from 10 years of age.
Croatian: CHMP je zaključio da jedna doza može potaknuti zadovoljavajući imunosni odgovor u odraslih osoba (uključujući i starije osobe), adolescenata i djece u dobi iznad 10 godina.
English: The solvent contains an ‘adjuvant' (a compound containing oil) to enhance the immune response.
Croatian: Emulzija sadrži „adjuvans” (spoj koji sadrži ulje) da bi se pojačala imunosna reakcija.
English: Six main studies have been carried out that looked at the ability of a two-dose schedule of the vaccine to trigger an immune response in the following groups (the numbers given are for those who received Pandemrix in the studies):
Croatian: Provedeno je šest glavnih ispitivanja koja su istražila može li raspored s dvije doze cjepiva aktivirati imunosnu reakciju u sljedećim skupinama (navedeni brojevi odnose se na osobe koje su primile lijek Pandemrix tijekom ispitivanja):
English: Pandemrix is given as one dose, injected into the muscle of the shoulder or thigh.
Croatian: Pandemrix se primjenjuje kao jedna doza, ubrizgana u mišić ramena ili bedra.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Pandemrix on 20 May 2008.
Croatian: Europska komisija izdala je odobrenje za stavljanje u promet koje je za lijek Pandemrix na snazi u Europskoj uniji od 20. svibnja 2008.
English: What measures are being taken to ensure the safe and effective use of Pandemrix?
Croatian: Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Pandemrix?
English: • healthy children (210 aged between three and 17 years, and 50 aged between six and 35 months, in three studies).
Croatian: • zdrava djeca (210 u dobi između tri i 17 godina, te 50 u dobi između šest i 35 mjeseci, u tri ispitivanja).
English: • healthy elderly subjects over the age of 60 years (120 subjects in one study);
Croatian: • zdrave starije osobe u dobi iznad 60 godina (120 osoba u jednom ispitivanju);
English: Following rare cases of narcolepsy (a rare sleep disorder that causes a person to fall asleep suddenly and unexpectedly) among people given the vaccine, it was concluded that Pandemrix should only be used if the recommended seasonal influenza vaccine is not available and if immunisation against H1N1 is still needed.
Croatian: Nakon rijetkih slučajeva narkolepsije (rijetkog poremećaja uslijed kojeg osoba iznenada i neočekivano zaspi) među ljudima koji su primili cjepivo, zaključeno je da se Pandemrix treba koristiti samo ako preporučeno cjepivo protiv sezonske influence nije dostupno, a imunizacija protiv H1N1 je još uvijek potrebna.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Pandemrix.
Croatian: Objašnjava kako je Odbor za lijekove za humanu uporabu (CHMP) ocijenio lijek da bi donio svoje mišljenje u korist izdavanja odobrenja za stavljanje lijeka u promet i svoje preporuke za uporabu lijeka Pandemrix.
English: This document is a summary of the European Public Assessment Report (EPAR) for Pandemrix.
Croatian: Ovo je sažetak europskoga javnog izvješća o ocjeni dokumentacije (EPAR) o lijeku Pandemrix.
English: When a person is given the vaccine, the immune system recognises the virus as ‘foreign' and makes antibodies against it.
Croatian: Kada osoba primi cjepivo, imunosni sustav prepoznaje virus kao „strano tijelo” i proizvodi protutijela na virus.
English: It should only be used if the recommended annual seasonal trivalent/quadrivalent influenza vaccine is not available and if immunisation against (H1N1)v is considered necessary.
Croatian: Smije se primijeniti samo u slučajevima kada preporučena godišnja sezonska trovalentna/četverovalentna cjepiva protiv influence nisu dostupna te ako se imunizacija protiv (H1N1)v smatra nužnom.
English: Pandemrix must not be given to people who have had an anaphylactic reaction (severe allergic reaction) to any of the components of the vaccine, or to any of the substances found at trace (very low) levels in the vaccine, such as egg or chicken protein, ovalbumin (a protein in egg white), formaldehyde, gentamicin sulphate (an antibiotic) and sodium deoxycholate.
Croatian: Pandemrix se ne smije primjenjivati u osoba koje su imale anafilaktičku reakciju (tešku alergijsku reakciju) na bilo koju komponentu cjepiva ili na bilo koju tvar prisutnu u tragovima (u vrlo malim količinama) u cjepivu, kao što su protein iz jaja ili piletine, ovalbumin (protein bjelanjka), formaldehid, gentamicin sulfat (antibiotik) i natrij deoksikolat.
English: Pandemrix is given according to official recommendations.
Croatian: Pandemrix se primjenjuje sukladno službenim preporukama.
English: Pandemrix influenza vaccine (H1N1)v (split virion, inactivated, adjuvanted)
Croatian: Pandemrix cjepivo protiv influence (H1N1)v (fragmentirani virion, inaktivirano, adjuvantirano)
English: • healthy adults aged between 18 and 60 years (180 subjects in two studies);
Croatian: • zdrave odrasle osobe u dobi od 18 do 60 godina (180 osoba u dva ispitivanja);
English: Other information about Pandemrix
Croatian: Ostale informacije o lijeku Pandemrix
English: Before use, the vaccine is made up by mixing together a suspension that contains the virus particles with a solvent.
Croatian: Prije uporabe, cjepivo se priprema miješanjem suspenzije koja sadrži čestice virusa s otapalom.
English: In all of the studies, the vaccine was shown to bring about protective levels of antibodies to a satisfactory level, in line with the criteria laid down by the CHMP.
Croatian: U svim ispitivanjima, utvrđeno je da cjepivo proizvodi zaštitne razine protutijela u zadovoljavajućoj koncentraciji, u skladu s kriterijima koje je utvrdio CHMP.
English: The vaccine can only be obtained with a prescription.
Croatian: Ovo se cjepivo izdaje samo na liječnički recept.
English: A risk management plan has been developed to ensure that Pandemrix is used as safely as possible.
Croatian: Pripremljen je plan upravljanja rizikom kako bi se osigurala što sigurnija primjena lijeka Pandemrix.
English: The most common side effects with Pandemrix in adults (seen with more than 1 in 10 doses of the vaccine) are headache, arthralgia (joint pain), myalgia (muscle pain), swelling and pain at the site of the injection, shivering, increased sweating and fatigue (tiredness).
Croatian: Najčešće nuspojave pri primjeni lijeka Pandemrix uočene u odraslih osoba (uočene kod više od 1 na 10 doza cjepiva) su glavobolja, artralgija (bolni zglobovi), mijalgija (mišićna bol), oticanje i bolna mjesta injekcije, drhtavica, pojačano znojenje iscrpljenost (umor).
English: In children aged between six months and nine years, 0.25 ml doses were as effective as 0.5 ml doses.
Croatian: U djece u dobi između šest mjeseci i devet godina, doze od 0,25 ml bile su jednako djelotvorne kao i doze od 0,5 ml.
English: Pandemrix is a vaccine that is given by injection.
Croatian: Pandemrix je cjepivo koje se primjenjuje injekcijom.
English: Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Pandemrix, including the appropriate precautions to be followed by healthcare professionals and patients.
Croatian: Na temelju tog plana, u sažetku opisa svojstava lijeka kao i u uputi za lijek Pandemrix nalaze se sigurnosne informacije, uključujući odgovarajuće mjere opreza kojih se zdravstveni djelatnici i bolesnici trebaju pridržavati.
English: The CHMP decided that Pandemrix's benefits are greater than its risks and recommended that it be given marketing authorisation.
Croatian: CHMP je odlučio da koristi od lijeka Pandemrix nadmašuju s njim povezane rizike te je preporučio izdavanje odobrenja za stavljanje lijeka u promet.
English: From 10 years of age the dose is 0.5 ml; younger children aged from six months to nine years receive 0.25 ml per dose.
Croatian: U djece starije od 10 godina doza iznosi 0,5 ml; mlađa djeca u dobi od šest mjeseci do devet godina trebaju primiti 0,25 ml po dozi.
English: Pandemrix was originally developed as a pandemic vaccine, and was used during the influenza A (H1N1) pandemic declared in June 2009.
Croatian: Pandemrix je prvobitno razvijen kao pandemijsko cjepivo, a korišten je tijekom pandemije influence A (H1N1) objavljene u lipnju 2009.
English: The studies in children also allowed the effectiveness of Pandemrix as a 0.5 ml dose to be compared with that of a 0.25 ml dose.
Croatian: Ispitivanja provedena u djece omogućila su usporedbu djelotvornosti lijeka Pandemrix u dozi od 0,5 ml i u dozi od 0,25 ml.
English: Pandemrix is a vaccine.
Croatian: Pandemrix je cjepivo.
English: Pandemrix contains a flu strain called A/California/7/2009 (H1N1)v-like strain (X-179A).
Croatian: Pandemrix sadrži soj gripe naziva soj virusa poput A/California/7/2009 (H1N1)v (X-179A).
English: What is the risk associated with Pandemrix?
Croatian: Koji su rizici povezani s lijekom Pandemrix?
English: Why has Pandemrix been approved?
Croatian: Zašto je Pandemrix odobren?
English: The full EPAR for Pandemrix can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Croatian: Cjeloviti EPAR za lijek Pandemrix nalazi se na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports Više informacija o terapiji lijekom Pandemrix pročitajte u uputi o lijeku (također dio EPAR-a) ili se obratite svom liječniku ili ljekarniku.
English: What is Pandemrix?
Croatian: Što je Pandemrix?
English: Pandemrix is a vaccine to protect against flu caused by the A (H1N1)v 2009 virus.
Croatian: Pandemrix je cjepivo za zaštitu od gripe uzrokovane virusom A (H1N1)v 2009.
English: Pandemrix contains small amounts of haemagglutinins (proteins from the surface) of a virus called A(H1N1)v 2009.
Croatian: Pandemrix sadrži male količine hemaglutinina (proteina s površine) virusa naziva A(H1N1)v 2009.
English: What benefit has Pandemrix shown during the studies?
Croatian: Koje su koristi lijeka Pandemrix dokazane u ispitivanjima?
English: For the full list of all side effects reported with Pandemrix, see the package leaflet.
Croatian: Potpuni popis nuspojava zabilježenih pri primjeni lijeka Pandemrix potražite u uputi o lijeku.
English: What is Pandemrix used for?
Croatian: Za što se Pandemrix koristi?
English: How is Pandemrix used?
Croatian: Kako se Pandemrix koristi?
English: How does Pandemrix work?
Croatian: Kako djeluje Pandemrix?
English: How has Pandemrix been studied?
Croatian: Kako je Pandemrix ispitivan?
English: Poliovirus (Inactivated)3 Type 1 (Mahoney)
Croatian: Virus poliomijelitisa (inaktiviran)3 Tip 1 (Mahoney)
English: 50 (5 x 10) pre-filled syringes (multipack)
Croatian: 50 (5 x 10) napunjenih štrcaljki (višestruko pakiranje)
English: MA (EU) number (Invented) name
Croatian: Broj EU odobrenja (Zaštićeno ime)
English: --1 One dose1 (0.5 ml) contains: Diphtheria Toxoid
Croatian: --1 Jedna doza1 (0,5 ml) sadrži: Toksoid difterije
English: Content (concentration)
Croatian: Unutarnji spremnik Količina (koncentracija)
English: Intramuscular use vial (glass)
Croatian: Veličina pakovanja bočica (staklo)
English: Volume: {Z} mL
Croatian: Volumen: {Z} ml
English: Activity: {Y} MBq in {Z}mL ToC: {DD/MM/YYYY} {hh:mm}{Time Zone} Vial No.
Croatian: Aktivnost: {Y} MBq u{Z}ml ToC: {DD/MM/GGGG} {ss:mm}{Vremenska zona}
English: If you are pregnant
Croatian: Ako ste trudni
English: It might be helpful to estimate the effective dose that was applied.
Croatian: Moglo bi biti korisno procijeniti kolika je efektivna doza primijenjena.
English: However, in the case of an overdose, you will receive the appropriate treatment.
Croatian: Međutim, u slučaju predoziranja primit ćete odgovarajuće liječenje.
English: The physician training course should contain the following key elements:
Croatian: Obuka liječnika mora obuhvatiti sljedeće ključne elemente:
English: The volume of the injection should not be less than 1 mL and not exceed 10 mL.
Croatian: Volumen injekcije ne smije biti manji od 1 ml niti veći od 10 ml.
English: Radioactive material
Croatian: Radioaktivan materijal
English: If the quantitation result is inconsistent with the initial visual interpretation:
Croatian: Ako se rezultat kvantifikacije ne podudara s prvobitnom vizualnom interpretacijom:
English: 10010 Colleretto Giacosa (TO) Italy
Croatian: 10010 Colleretto Giacosa (TO) Italija
English: Amyvid will only be used in specially controlled areas.
Croatian: Amyvid se primjenjuje samo u posebno kontroliranim prostorima.
English: No studies have been conducted in pregnant women.
Croatian: Nisu provedena ispitivanja u trudnica.
English: One injection is usually sufficient to carry out the scan that your doctor needs.
Croatian: Jedna injekcija obično je dovoljna za oslikavanje koje je liječniku potrebno.
English: It will be the smallest quantity necessary to get the desired information.
Croatian: Bit će to najniža količina lijeka potrebna za dobivanje željenih informacija.
English: Cases should be histopathologically confirmed, if possible.
Croatian: Slučajevi bi, ako je to moguće, trebali biti histopatološki potvrđeni.
English: The basis for making a visual positive or negative determination should be reviewed: a.
Croatian: Treba ponovno razmotriti temelj za pozitivan ili negativan nalaz vizualne interpretacije: a.
English: Their results closely paralleled the results obtained in the pivotal trial.
Croatian: Njihovi rezultati bili su vrlo slični rezultatima dobivenima u pivotalnom ispitivanju.
English: Their receipt, storage, use, transfer and disposal are subject to the regulations and/or appropriate licences of the competent official organisation.
Croatian: Njihovo preuzimanje, čuvanje, primjena, prijenos i zbrinjavanje podložni su propisima i/ili odgovarajućim dozvolama koje izdaje nadležna službena organizacija.
English: 08950 Espluges de Llobregat, Barcelona Spain
Croatian: 08950 Espluges de Llobregat, Barcelona Španjolska
English: Organ/tissue
Croatian: Organ/tkivo
English: Date of latest renewal: 21 September 2017
Croatian: Datum posljednje obnove odobrenja: 21. rujan 2017.
English: The radioactive half-life of 18F is 110 minutes.
Croatian: Radioaktivni poluvijek 18F iznosi 110 minuta.
English: This dose is approximately 500 times the maximum human dose, and showed no evidence of mutagenicity.
Croatian: Navedena doza je približno 500 puta veća od najveće doze u ljudi, a nije pokazala mutagenost.
English: The cognitive status of the subjects could not be reliably measured.
Croatian: Kognitivni status ispitanika nije se mogao pouzdano izmjeriti.
English: Possible structural anomalies that could influence quantitation of the cerebellar region should be considered.
Croatian: Treba razmotriti moguće strukturne anomalije koje bi mogle utjecati na kvantifikaciju regije malog mozga.
English: Animal toxicology and safety pharmacology
Croatian: Toksikologija i sigurnosna farmakologija u životinja
English: Other medicines and Amyvid
Croatian: Drugi lijekovi i Amyvid
English: Children and adolescents Amyvid is not intended for use in children and adolescents.
Croatian: Djeca i adolescenti Amyvid nije namijenjen za primjenu u djece i adolescenata.
English: Megabecquerel (MBq) is the unit used to express radioactivity.
Croatian: Megabecquerel (MBq) je jedinica kojom se izražava radioaktivnost.
English: The design of this study does not allow estimating the risk of MCI progression to clinical AD.
Croatian: Dizajn navedenog ispitivanja ne omogućuje procjenu rizika progresije MCI-ja prema kliničkom AB-u.
English: See also section 1.
Croatian: Vidjeti i dio 1.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your nuclear medicine doctor for advice before you are given this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se liječniku specijalistu nuklearne medicine za savjet prije nego primite ovaj lijek.
English: Only essential investigations should therefore be carried out during pregnancy, when the likely benefit far exceeds the risk incurred by the mother and foetus.
Croatian: Stoga tijekom trudnoće treba provoditi samo neophodne pretrage, kada je vjerojatna korist mnogo veća od rizika za majku i plod.
English: A final interpretation of the scan should be made based on the final visual read after conducting resolution steps 1-3 above.
Croatian: Konačnu interpretaciju snimka treba temeljiti na završnoj vizualnoj interpretaciji nakon provedbe koraka od 1 do 3.
English: What Amyvid is and what it is used for
Croatian: Što je Amyvid i za što se koristi
English: The highest level of uptake is in regions mainly composed of white matter (pons and centrum semiovale).
Croatian: Najveće nakupljanje primijećeno je u regijama koje uglavnom sačinjava bijela tvar (pons i centrum semiovale).
English: The nuclear medicine doctor will inform you if you need to take any special precautions after receiving this medicine.
Croatian: Liječnik specijalist nuklearne medicine reći će Vam morate li poduzeti posebne mjere opreza nakon što primite ovaj lijek.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: • uoči svake izmjene sustava za upravljanje rizikom, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je izmjena rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili minimizacije rizika).
English: Amyvid should be used in conjunction with a clinical evaluation.
Croatian: Amyvid treba primjenjivati u kombinaciji s kliničkom procjenom.
English: Reconstruction should include attenuation correction with resulting transaxial pixel sizes between 2.0 and 3.0 mm.
Croatian: Rekonstrukcija mora uključivati korekciju zbog atenuacije tako da konačna transaksijalna veličina piksela bude između 2,0 i 3,0 mm.
English: Training should include a sufficient number of clearly positive and negative cases as well as intermediate level cases.
Croatian: Obuka mora obuhvatiti dovoljan broj slučajeva s jasnim pozitivnim i jasnim negativnim nalazima, kao i slučajeve s dvojbenim nalazima.
English: While they may in reality occur at lower frequencies than indicated below, the size of the source database did not allow for the assignment of frequency categories lower than the category “uncommon” (≥1/1,000 to <1/100).
Croatian: Iako se u stvarnosti mogu javiti rjeđe nego što je ovdje navedeno, veličina polazišne baze podataka nije omogućila svrstavanje nuspojava u kategoriju učestalosti manju od “manje često” (≥1/1000 i < 1/100).
English: Navarra 3-5 Pol. Ind. La Cuesta, Sector 3 50100 La Almunia de Doña Godina Zaragoza
Croatian: Ind. La Cuesta, Sector 3 50100 La Almunia de Doňa Godina Zaragoza
English: Amyvid contains ethanol and sodium
Croatian: Amyvid sadrži etanol i natrij
English: The nuclear medicine doctor supervising the procedure will decide on the quantity of Amyvid to be used in your case.
Croatian: Liječnik specijalist nuklearne medicine koji će nadzirati postupak odredit će količinu lijeka Amyvid primjerenu u Vašem slučaju.
English: Via Piero Maroncelli 40
Croatian: S.r.l. Via Piero Maroncelli40
English: Tell your nuclear medicine doctor if you are taking, have recently taken or might take any other medicines since they may interfere with the interpretation of the images obtained from the brain scan.
Croatian: Obavijestite liječnika specijalista nuklearne medicine ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove jer oni mogu utjecati na interpretaciju snimaka dobivenih oslikavanjem mozga.
English: This may be harmful to those suffering from alcoholism.
Croatian: Lijek stoga može biti štetan za alkoholičare.
English: Prior to launch in each Member State the Marketing Authorisation Holder (MAH) shall agree the final educational programme with the National Competent Authority.
Croatian: Prije stavljanja lijeka na tržište u svakoj državi članici nositelj odobrenja će s nadležnim nacionalnim tijelom dogovoriti konačan edukacijski program.
English: Only polypropylene/HDPE syringes should be used.
Croatian: Smiju se koristiti samo polipropilenske/HDPE štrcaljke.
English: Paediatric population For information on the use in the paediatric population, see sections 4.2 or 5.1.
Croatian: Pedijatrijska populacija Za podatke o primjeni u pedijatrijskoj populaciji vidjeti dijelove 4.2 i 5.1.
English: Dose absorbed per activity administered (µGy/MBq) Average
Croatian: Apsorbirana doza po primijenjenoj aktivnosti (µGy/MBq) Prosjek
English: Specificity
Croatian: Specifičnost
English: The following information is intended for the specialist only.
Croatian: Sljedeće informacije namijenjene su samo liječniku specijalistu.
English: Amyvid, along with other brain function tests, may help your doctor find the reason for your memory problems.
Croatian: Amyvid, zajedno s drugim testovima moždane funkcije, može pomoći Vašem liječniku da otkrije zašto imate tegoba s pamćenjem.
English: Fertility No studies on fertility have been performed.
Croatian: Plodnost Nisu provedena ispitivanja plodnosti.
English: Amyvid must not be used - if you are allergic to florbetapir (18F) or any of the other ingredients of this medicine (listed in section 6).
Croatian: Amyvid se ne smije primijeniti - ako ste alergični na florbetapir (18F) ili neki drugi sastojak ovoga lijeka (naveden u dijelu 6.).
English: Your doctor and the nuclear medicine doctor have considered that the benefit of this procedure with the radiopharmaceutical outweighs the risk of being exposed to radiation.
Croatian: Vaš liječnik i specijalist nuklearne medicine zaključili su da prednosti ove pretrage u kojoj se primjenjuje radiofarmaceutik nadmašuju rizik od izlaganja zračenju.
English: In all 59 subjects, a blinded PET reading by 5 nuclear medicine physicians resulted in a majority read sensitivity of 92% (95% CI: 78-98%) and specificity of 100% (95% CI: 80-100%).
Croatian: U svih je 59 ispitanika slijepo očitanje PET nalaza koje je provelo 5 liječnika specijalista nuklearne medicine većinom pokazalo osjetljivost interpretacije od 92% (95% CI: 78-98%) i specifičnost od 100% (95% CI: 80-100%).
English: Exposure to ionising radiation is linked with cancer induction and a potential for development of hereditary defects.
Croatian: Izlaganje ionizirajućem zračenju povezano je s nastankom raka i mogućim razvojem nasljednih oštećenja.
English: Inter-rater agreement using Fleiss' kappa values ranged from 0.75 to 0.85.
Croatian: Slaganje među ocjeniteljima primjenom Fleiss kappa vrijednosti kretalo se u rasponu od 0,75 do 0,85.
English: Each vial is enclosed in a shielded container of appropriate thickness to minimise external radiation exposure.
Croatian: Svaka bočica se nalazi u posebnom zaštitnom spremniku odgovarajuće debljine kako bi se vanjsko zračenje svelo na minimum.
English: In this assay, florbetapir did not increase the number of micronucleated polychromatic erythrocytes at the highest achievable dose level, 372 µg/kg/day, when given twice daily for 3 consecutive days.
Croatian: U tom testu florbetapir nije povećao broj mikronukleusnih polikromatskih eritrocita pri najvećoj mogućoj dozi, 372 µg/kg na dan, kada je primjenjivan dvaput na dan tijekom 3 uzastopna dana.