FrancophonIA/ELRC3.0 huggingface dataset:
English: • strengthened warnings on sun exposure should be included in the product information, as well as advice to stop using topical ketoprofen if any skin reactions develop, including when using ketoprofen together with octocrylene;
Slovenian: • v informacije o zdravilu je treba vključiti več opozoril o izpostavljanju soncu ter napotek o prenehanju uporabe topičnega ketoprofena v primeru pojava neželenih kožnih reakcij, vključno pri sočasni uporabi topičnega ketoprofena in oktokrilena;
English: • Doctors should tell their patients how to use topical ketoprofen-containing medicines appropriately.
Slovenian: • zdravniki morajo svojim bolnikom dati ustrezna navodila o uporabi topičnih zdravil, ki vsebujejo ketoprofen;
English: The Committee also noted that, although alternative topical NSAIDs are available in the EU, ketoprofen is the only topical NSAID authorised for the treatment of acute lowback pain.
Slovenian: Odbor je tudi ugotovil, da je ketoprofen edino topično nesteroidno protivnetno zdravilo, odobreno za zdravljenje akutne bolečine v križu, kljub razpoložljivosti alternativnih topičnih nesteroidnih protivnetnih zdravil v EU.
English: • Patients should discontinue treatment immediately if they develop any skin reaction after application of these medicines, and seek their doctor's advice.
Slovenian: • če se po uporabi opisanih zdravil pojavi kakršna koli kožna reakcija, morajo bolniki nemudoma prekiniti zdravljenje in se posvetovati z zdravnikom;
English: They should also wash their hands carefully after each application of ketoprofen.
Slovenian: Po vsakem nanosu ketoprofena si morajo temeljito umiti roke;
English: The European Commission issued a decision on 13 September 2011.
Slovenian: Evropska komisija je odločbo izdala dne 13. septembra 2011.
English: • Patients who have any questions should speak to their doctor.
Slovenian: • Bolniki, ki imajo kakršna koli vprašanja, naj se posvetujejo s svojim zdravnikom.
English: Medicines containing dexrazoxane are authorised for the prevention of cardiotoxic effects in Austria, Czech Republic, Germany, Denmark, Finland, France, Greece, Hungary, Ireland, Italy, Lithuania, Luxembourg, Netherlands, Norway, Poland, Portugal, Romania, Slovakia Spain and the United Kingdom under the following invented names: Cardioxane, Cyrdanax, Dexrazoxane Cyathus, Enaxozar and Procard.
Slovenian: Zdravila, ki vsebujejo deksrazoksan, so odobrena za preprečevanje kardiotoksičnih učinkov v Avstriji, Češki republiki, Nemčiji, na Danskem, Finskem, v Franciji, Grčiji, na Madžarskem, Irskem, v Italiji, Litvi, Luksemburgu, na Nizozemskem, Norveškem, Poljskem, Portugalskem, v Romuniji, na Slovaškem, v Španiji in Združenem kraljestvu pod naslednjimi lastniškimi imeni: Cardioxane, Cyrdanax, Dexrazoxane Cyathus, Enaxozar in Procard.
English: EMA/CHMP/485343/2011 rev.1 EMEA/H/A-31/1275
Slovenian: EMA/773275/2011 rev. 1 EMEA/H/A-31/1275
English: What are the recommendations for patients and prescribers?
Slovenian: Kakšna so priporočila za zdravnike, ki predpisujejo zdravila, in bolnike?
English: The Committee also reviewed all available data on the safety and effectiveness of dexrazoxane, including published studies and data submitted by the companies that market the medicines.
Slovenian: Odbor je pregledal tudi vse razpoložljive podatke o varnosti in učinkovitosti deksrazoksana, vključno z objavljenimi študijami in podatki, ki so jih predložile družbe, ki tržijo zdravila.
English: The European Medicines Agency has completed a review of the safety and effectiveness of dexrazoxane.
Slovenian: Evropska agencija za zdravila je zaključila pregled varnosti in učinkovitosti deksrazoksana.
English: There was also an increased risk of severe myelosuppression (a condition in which the bone marrow cannot make enough blood cells) and severe infection.
Slovenian: Prisotno je bilo tudi povečano tveganje hude mielosupresije (stanja, pri katerem kostni mozeg ne uspe proizvesti zadostnega števila krvnih celic) in hudih okužb.
English: • Information on recommended dosing and additional information on the risks associated with dexrazoxane can be found in the updated prescribing information.
Slovenian: • Informacije o priporočenem odmerjanju in dodatne informacije o tveganjih, povezanih z deksrazoksanom, so na voljo v posodobljenih podatkih o predpisovanju zdravila.
English: The UK medicines regulatory agency also shared these concerns and asked the CHMP to carry out a full assessment of the benefit-risk balance of dexrazoxane and to issue an opinion on
Slovenian: Tudi regulativna agencija za zdravila v Združenem kraljestvu je izrazila te pomisleke in pozvala CHMP, naj izvede celovito oceno razmerja med koristmi in tveganji za
English: whether the marketing authorisations for products containing dexrazoxane should be maintained, varied, suspended or withdrawn across the European Union.
Slovenian: deksrazoksan ter izda mnenje o tem, ali se dovoljenja za promet z zdravili, ki vsebujejo deksrazoksan, v Evropski uniji ohranijo, spremenijo, začasno umaknejo ali umaknejo.
English: The Committee also noted that in one study in breast cancer patients, dexrazoxane was associated with worsened response to cancer therapy while other studies showed an increased risk of dying in the first few months of treatment with dexrazoxane at a dose ratio of 20: 1 (20 parts dexrazoxane for 1 part of doxorubicin).
Slovenian: Odbor je ugotovil tudi, da je deksrazoksan v eni študiji z bolnicami z rakom dojk poslabšal odziv na zdravljenje proti raku, medtem ko so druge študije pokazale povečano tveganje umrljivosti v prvih nekaj mesecih zdravljenja z deksrazoksanom v razmerju odmerka 20:1 (20 delov deksrazoksana proti 1 delu doksorubicina).
English: • Dexrazoxane should only be used in adult patients who have already received a minimum cumulative anthracycline dose of 300 mg/m2 of doxorubicin, or 540 mg/m2 of epirubicin.
Slovenian: • Deksrazoksan se lahko uporablja samo pri odraslih bolnicah, ki so že prejele minimalni kumulativni antraciklinski odmerek 300 mg/m2 doksorubicina ali 540 mg/m2 epirubicina.
English: The way in which dexrazoxane protects the heart is not entirely clear, but may be linked to the way the medicine attaches to charged iron particles that are involved in the processes that make anthracyclines toxic to the heart muscle.
Slovenian: Ni povsem jasno, kako deksrazoksan varuje srce, vendar je to verjetno povezano z načinom vezave zdravila na železove ione, ki sodelujejo v postopkih, zaradi katerih so antraciklini toksični za srčno mišico.
English: The Agency's Committee for Medicinal Products for Human Use (CHMP) has concluded that dexrazoxane should not be used in children and adolescents.
Slovenian: Odbor za zdravila za uporabo v humani medicini (CHMP) pri Agenciji je zaključil, da se deksrazoksan ne sme uporabljati pri otrocih in mladostnikih.
English: In addition to the restriction in the medicine's use, the CHMP has recommended a reduced dose ratio of 10:1 with doxorubicin (the dose ratio remains 10:1 for epirubicin) in adults and has included in the SmPCs more information on what is currently known about the risks of dexrazoxane-containing medicine.
Slovenian: Poleg omejitve uporabe zdravila je CHMP priporočil zmanjšano razmerje odmerka 10:1 z doksorubicinom (razmerje med epirubicinom in doksorubicinom 10:1) pri odraslih ter v povzetek glavnih značilnosti zdravila vključil več informacij o tveganjih pri zdravilih, ki vsebujejo deksrazoksan.
English: The CHMP concluded that the benefits of dexrazoxanecontaining medicines do not outweigh its risk in children and adolescents, and the medicine should not be used in these age-groups.
Slovenian: CHMP je zaključil, da koristi zdravil, ki vsebujejo deksrazoksan, ne odtehtajo z njim povezanih tveganj pri otrocih in mladostnikih, zato se zdravilo v tej starostni skupini ne sme uporabljati.
English: What is dexrazoxane?
Slovenian: Kaj je deksrazoksan?
English: The Committee noted that there was evidence of serious harm in children receiving dexrazoxane.
Slovenian: Odbor je opozoril, da obstajajo dokazi hudih škodljivih vplivov pri otrocih, ki prejemajo deksrazoksan.
English: • When deciding whether to use dexrazoxane prescribers should consider the short- and long-term risks associated with this product (e.g. myelosuppression and the potential for AML), alongside possible benefits in relation to protection of the heart.
Slovenian: • Pri odločanju glede uporabe deksrazoksana morajo zdravniki, ki predpisujejo zdravilo, ob možnih koristih za zaščito srca preučiti tudi kratkoročna in dolgoročna tveganja, povezana z zdravilom (npr. mielosupresija in možnost za akutno mieloidno levkemijo).
English: The Committee has also made recommendations for changes to the summaries of product characteristics (SmPCs) for dexrazoxanecontaining medicines.
Slovenian: Odbor je tudi podal priporočila za spremembe povzetkov glavnih značilnosti zdravil, ki vsebujejo deksrazoksan.
English: Why was dexrazoxane reviewed?
Slovenian: Zakaj je bil deksrazoksan pregledan?
English: Dexrazoxane is used in patients with cancer to prevent long-tem toxic effects on the heart caused by treatment with the anticancer medicines doxorubicin and epirubicin.
Slovenian: Deksrazoksan se uporablja pri bolnikih z rakom za preprečevanje dolgoročnih toksičnih učinkov na srce, ki nastanejo zaradi zdravljenja z zdraviloma proti raku doksorubicinom in epirubicinom.
English: The French medicines regulatory agency raised concerns that dexrazoxane could be linked to an increased risk of two cancers: acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS).
Slovenian: Francoska regulativna agencija za zdravila je izrazila pomisleke, da utegne deksrazoksan vplivati na povečano tveganje dveh vrst raka: akutna mieloidna levkemija in mielodisplastični sindrom.
English: The use of dexrazoxane should be restricted to adult patients with advanced or metastatic breast cancer who have already received a certain amount of doxorubicin and epirubicin.
Slovenian: Uporabo deksrazoksana je treba omejiti na odrasle bolnice z napredovalim ali metastatičnim rakom dojk, ki so že prejele ustrezno količino doksorubicina in epirubicina.
English: • Dexrazoxane should only be used in adult patients with advanced or metastatic breast cancer.
Slovenian: • Deksrazoksan se lahko uporablja samo pri odraslih bolnicah z napredovalim ali metastatskim rakom dojk.
English: These concerns were based on studies in the United States reporting cases of AML and MDS in children with Hodgkin's disease as well as cases of AML reported in breast cancer patients receiving dexrazoxane.
Slovenian: Ti pomisleki so temeljili na študijah primerov akutne mieloidne levkemije in mielodisplastičnega sindroma v ZDA pri otrocih s Hodgkinovo boleznijo in primerov akutne mieloidne levkemije pri bolnicah z rakom dojk, ki so prejemale deksrazoksan.
English: The use of dexrazoxane should be contraindicated in children and adolescents.
Slovenian: Uporaba deksrazoksana pri otrocih in mladostnikih mora biti kontraindicirana.
English: Studies showed a three-fold increase in the risk of new cancers such as AML and MDS.
Slovenian: Iz študij je bilo razvidno trikratno povečanje tveganja novih vrst raka, kot sta akutna mieloidna levkemija in mielodisplastični sindrom.
English: The benefits of dexrazoxane do not outweigh its risks in children and adolescents.
Slovenian: Koristi deksrazoksana pri otrocih in mladostnikih ne odtehtajo z njim povezanih tveganj.
English: The CHMP reviewed reports on AML and MDS in patients receiving dexrazoxane.
Slovenian: CHMP je pregledal poročila o primerih akutne mieloidne levkemije in mielodisplastičnega sindroma pri bolnikih, ki prejemajo deksrazoksan.
English: • Seek urgent medical assistance.
Slovenian: • poiščite nujno zdravniško pomoč.
English: You may become sleepy and could lose consciousness.
Slovenian: Lahko postanete zaspani in izgubite zavest.
English: In addition there has been extensive post-marketing experience with zonisamide in Japan since 1989 and in the USA since 2000.
Slovenian: Poleg tega obstajajo obširne postmarketinške izkušnje z zonisamidom na Japonskem od leta 1989 in v ZDA od leta 2000.
English: IF ANY OF THE FOLLOWING OCCUR, THE CHILD NEEDS URGENT MEDICAL ATTENTION:
Slovenian: ČE SE ZGODI KAR KOLI OD NASLEDNJEGA, OTROK POTREBUJE NUJNO ZDRAVNIŠKO POMOČ:
English: In children, this combination is not recommended
Slovenian: Pri otrocih se ta kombinacija ne priporoča.
English: † MedDRA version 13.1
Slovenian: † Različica MedDRA 13.1
English: Effect of food
Slovenian: Učinki hrane
English: The frequencies are arranged according to the following scheme:
Slovenian: Pogostost je opredeljena po sledeči shemi:
English: Do not give this medicine to children below the age of 6 years because it is not known for this age group whether the potential benefits are greater than the risks.
Slovenian: Tega zdravila ne dajajte otrokom, mlajšim od 6 let, saj za to starostno skupino ni znano, ali so morebitne koristi večje od tveganj.
English: • live in a place or are on holiday in a place where the weather is warm.
Slovenian: • če živite ali dopustujete v kraju, kjer je vreme toplo.
English: • Zonegran can be taken once or twice daily, as instructed by your doctor.
Slovenian: • Zdravilo Zonegran lahko jemljete enkrat ali dvakrat na dan, kot vam je naročil zdravnik.
English: General supportive care is indicated, including frequent monitoring of vital signs and close observation.
Slovenian: Indicirana je splošna podporna terapija, vključno s pogostim spremljanjem vitalnih znakov, in skrbno opazovanje.
English: They occur during the first month of treatment and usually decrease with continued treatment.
Slovenian: Pojavljajo se med prvim mesecem zdravljenja in se navadno ublažijo, ko se zdravljenje nadaljuje.
English: Return the pack to your pharmacist.
Slovenian: Odnesite škatlico nazaj v lekarno.
English: Paediatric population).
Slovenian: Pediatrična populacija).
English: Tell your doctor as this may need to be monitored.
Slovenian: O tem obvestite svojega zdravnika, ker bo mogoče to treba spremljati.
English: The mechanism of this risk is not known and the available data do not exclude the possibility of an increased risk for Zonegran.
Slovenian: Mehanizem tveganja ni znan, vendar razpoložljivi podatki ne izključujejo možnosti povečanega tveganja pri zdravilu Zonegran.
English: • Some people respond to lower doses.
Slovenian: • Nekateri ljudje se odzivajo že na manjše odmerke.
English: Example: A child who weighs 25 kg should take 25 mg once a day for the first week, and then increase the daily dose by 25 mg at the start of each week until a daily dose between 150 to 200 mg is reached.
Slovenian: Primer: Otrok, ki tehta 25 kg, naj vzame 25 mg enkrat na dan prvi teden, nato pa zveča dnevni odmerek za 25 mg na začetku vsakega tedna, dokler ni dosežen dnevni odmerek med 150 do 200 mg.
English: Do not use this medicine if you notice any damage to the capsules, blister or carton or any visible signs of deterioration in the medicine.
Slovenian: Ne uporabljajte tega zdravila, če opazite kakršno koli poškodbo kapsul, pretisnega omota ali škatlice ali kakšne vidne znake kvarjenja zdravila.
English: Symptoms may occur within hours to weeks of initiating therapy.
Slovenian: Simptomi se lahko pojavijo v nekaj urah do nekaj dneh po začetku zdravljenja.
English: None of these risk factors can reliably predict stone formation during zonisamide treatment.
Slovenian: Nobeden od teh dejavnikov tveganja ne more zanesljivo napovedati nastanka kamnov med zdravljenjem z zonisamidom.
English: Your doctor may decide that you should stop using Zonegran.
Slovenian: Mogoče bo zdravnik odločil, da morate prenehati jemati zdravilo Zonegran.
English: • Do not chew the capsules.
Slovenian: • Kapsul ne žvečite.
English: Use in children (aged 6 to 11 years) and adolescents (aged 12 to 17 years) weighing at least 20 kg:
Slovenian: Uporaba pri otrocih (starih 6 do 11 let) in mladostnikih (starih 12 do 17 let) s telesno maso vsaj 20 kg:
English: An updated RMP should be submitted: o At the request of the European Medicines Agency; o Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: Posodobljen RMP je treba predložiti: o na zahtevo Evropske agencije za zdravila; o ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: Zonegran may be taken with or without food (see section 5.2).
Slovenian: Zdravilo Zonegran se lahko jemlje s hrano ali brez nje (glejte poglavje 5.2).
English: Contact your doctor immediately if you:
Slovenian: Nemudoma se obrnite na svojega zdravnika, če:
English: In these cases it is therefore recommended that the Zonegran total dose should be rounded up or down to the nearest available dose that can be achieved with commercially available capsule strengths of Zonegran (25 mg, 50 mg and 100 mg).
Slovenian: Zato v teh primerih priporočajo, naj se celotni odmerek zdravila Zonegran zaokroži navzgor ali navzdol do najbližjega razpoložljivega odmerka, ki ga je možno doseči z jakostmi kapsul zdravila Zonegran, ki so komercialno na voljo (25 mg, 50 mg in 100 mg).
English: Zonisamide exposure increases with time until steady state is achieved by approximately 8 weeks.
Slovenian: Izpostavljenost zonisamidu s časom narašča, dokler ni po približno 8 tednih doseženo stanje dinamičnega ravnovesja.
English: Hatfield, Hertfordshire, AL10 9SN United Kingdom
Slovenian: Hatfield, Hertfordshire, AL10 9SN Velika Britanija
English: • are pregnant or could become pregnant (see section ‘pregnancy, breast-feeding and fertility' for further information).
Slovenian: • če ste noseči ali lahko zanosite (za več informacij glejte poglavje "Nosečnost, dojenje in plodnost").
English: The recommended adult dose
Slovenian: Priporočeni odmerek za odrasle
English: Do not reduce your dose or stop your medicine unless your doctor tells you to.
Slovenian: Ne zmanjšujte odmerka in ne prenehajte z zdravljenjem, razen če vam tako svetuje zdravnik.
English: • Sponge your child's skin with cool (not cold) water
Slovenian: • otrokovo kožo hladite s hladno (ne mrzlo) vodo,
English: What Zonegran is and what it is used for
Slovenian: Kaj je zdravilo Zonegran in za kaj ga uporabljamo
English: The metabolites, which could not be detected in plasma, are devoid of anticonvulsant activity.
Slovenian: Presnovki, ki jih ni možno zaslediti v plazmi, nimajo antikonvulzivne aktivnosti.
English: • Increased acid level in the blood and kidney stones: Reduce these risks by ensuring that your child drinks enough water and is not taking any other medicine which could cause kidney stones (see Other medicines).
Slovenian: • Zvišana raven kisline v krvi in ledvični kamni: Ta tveganja zmanjšajte tako, da zagotovite, da otrok pije dovolj vode in da ne jemlje drugih zdravil, ki bi lahko povzročila ledvične kamne (glejte Druga zdravila).
English: Eisai Manufacturing Ltd, European Knowledge Centre, Mosquito Way, Hatfield, Herts AL10 9SN, United Kingdom.
Slovenian: Eisai Manufacturing Ltd, European Knowledge Centre, Mosquito Way, Hatfield, Herts AL10 9SN, Velika Britanija.
English: Therefore patients should be monitored for signs of suicidal ideation and behaviours and appropriate treatment should be considered.
Slovenian: Zato je treba bolnike spremljati glede znakov samomorilnega razmišljanja in vedenja ter razmisliti o ustreznem zdravljenju.
English: A pooled analysis of safety data on 95 elderly subjects has shown a relatively higher reporting frequency of oedema peripheral and pruritus compared to the adult population.
Slovenian: Analiza združenih podatkov o varnosti pri 95 starejših osebah je pokazala relativno veliko pogostnost perifernega edema in pruritusa v primerjavi z odraslo populacijo.
English: The apparent volume of distribution is about 1.1 - 1.7 l/kg in adults indicating that zonisamide is extensively distributed to tissues.
Slovenian: Navidezni volumen porazdelitve pri odraslih je med 1,1 - 1,7 l/kg, kar kaže na to, da se zonisamid obsežno porazdeljuje v tkiva.
English: Zonegran with food and drink Zonegran can be taken with or without food.
Slovenian: Zdravilo Zonegran skupaj s hrano in pijačo Zdravilo Zonegran se lahko jemlje skupaj s hrano in pijačo ali brez njih.
English: • anger, aggression, thoughts of suicide, suicide attempt.
Slovenian: • bes, agresivnost, misli na samomor, poskus samomora;
English: Posology - Adults
Slovenian: Odmerjanje - odrasli
English: If you are younger than 6 years old, Zonegran is not recommended for you.
Slovenian: Če ste mlajši od 6 let, zdravilo Zonegran za vas ni priporočljivo;
English: The most common adverse reactions in controlled adjunctive-therapy studies were somnolence, dizziness and anorexia.
Slovenian: Najpogostejše neželene reakcije v kontroliranih študijah adjuvantnega zdravljenja so bile somnolenca, omotica in anoreksija.
English: Generally, zonisamideinduced metabolic acidosis occurs early in treatment although cases can occur at any time during treatment.
Slovenian: Ponavadi se metabolna acidoza, ki jo sproži zonisamid, pojavi zgodaj v poteku zdravljenja, primeri pa se lahko pojavijo kadarkoli med zdravljenjem.
English: Fluctuation in serum or plasma concentrations over a dosing interval is low (< 30 %).
Slovenian: Fluktuacije serumske ali plazemske koncentracije v intervalu odmerjanja so majhne (< 30 %).
English: Your doctor will monitor your child's blood bicarbonate levels and kidneys (see also section 4).
Slovenian: Vaš zdravnik bo spremljal ravni bikarbonata v krvi in ledvice vašega otroka (glejte tudi poglavje 4).
English: Zonegran capsules are packaged in blister packs supplied in boxes containing:
Slovenian: Zonegran kapsule so pakirane v pretisnih omotih v škatlah, ki vsebujejo:
English: • severe rashes or skin peeling (at the same time you may feel unwell or develop a fever).
Slovenian: • hudi izpuščaji ali luščenje kože (hkrati se lahko slabo počutite ali dobite vročino);
English: At this higher dose level, juvenile rats showed a decrease in growth, learning, and developmental parameters.
Slovenian: Pri teh višjih ravneh odmerkov se je pri podganjih mladičih pokazala upočasnitev parametrov rasti, učenja in razvoja.
English: Note: a. To ensure a therapeutic dose is maintained the weight of a child should be monitored and the dose reviewed as weight changes occur up to a weight of 55kg.
Slovenian: Opomba: a. Za zagotovitev vzdrževanja terapevtskega odmerka je treba nadzirati telesno maso otroka in ob spremembah telesne mase do 55 kg prilagoditi odmerek.
English: The incidence of markedly abnormally low serum bicarbonate (a decrease to less than 17 mEq/l and by more than 5 mEq/l) was 3.8%.
Slovenian: Incidenca znatno nenormalno znižanega serumskega bikarbonata (znižanje na manj kot 17 mEq/l in za več kot 5 mEq/l) je bila 3,8 %.
English: However, given that some patients may experience drowsiness or difficulty with concentration, particularly early in treatment or after a dose increase, patients must be advised to exercise caution during activities requiring a high degree of alertness, e.g., driving or operating machines.
Slovenian: Ker pa nekateri bolniki lahko občutijo zaspanost ali težave s koncentracijo, predvsem v začetku zdravljenja ali po povečanju odmerka, je treba bolnike opozoriti, da morajo biti previdni med aktivnostmi, ki zahtevajo visoko stopnjo zbranosti, npr. vožnja ali upravljanje strojev.
English: • It you take Zonegran twice a day, take half the daily dose in the morning and half in the evening.
Slovenian: • Če jemljete zdravilo Zonegran dvakrat na dan, vzemito polovico dnevnega odmerka zjutraj,
English: • Zonegran capsules must be swallowed whole with water.
Slovenian: • Kapsule zdravila Zonegran morate pogoltniti cele z nekaj vode.