FrancophonIA/ELRC3.0 huggingface dataset:
English: In females, at the high dose, there was a reduction in the weight of gravid uterus (0 to 16%) probably due to a reduction of the number of ovarian corporea lutea and implantations.
Slovenian: Pri samicah so ob velikem odmerku ugotovili zmanjšanje teže gravidne maternice (od 0 do 16 %), verjetno zaradi zmanjšanja števila rumenih telesc v jajčnikih in ugnezdenj..
English: (Telzir 1400 mg single dose)
Slovenian: (Telzir 1400 mg enkratni odmerek)
English: • If you have any further questions, ask your doctor or pharmacist.
Slovenian: • Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom ali s farmacevtom.
English: Ritonavir dose (TWICE DAILY)
Slovenian: Odmerek ritonavirja (DVAKRAT NA DAN)
English: Nucleoside / Nucleotide reverse transcriptase inhibitors:
Slovenian: Nukleozidni in nukleotidni zaviralci reverzne transkriptaze:
English: → Keep in touch with your doctor, and don't stop taking Telzir without your doctor's advice.
Slovenian: → Bodite v stiku s svojim zdravnikom in brez zdravnikovega nasveta zdravila Telzir ne nehajte jemati.
English: If Telzir/ritonavir is coadministered with parenteral midazolam, it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Slovenian: Če je zdravilo Telzir z ritonavirjem ali brez dano sočasno s parenteralno apliciranim midazolamom, naj se to zgodi na oddelku za intenzivno nego ali podobnem oddelku, ki omogoča skrbno klinično spremljanje bolnika in ustrezno ukrepanje v primeru respiratorne depresije in/ali podaljšane sedacije.
English: Frequency categories for the reactions below have been based on clinical trials and postmarketing data.
Slovenian: Kategorije pogostnosti v nadaljevanju navedenih neželenih učinkov temeljijo na podatkih, pridobljenih v kliničnih preskušanjih in ob spremljanju zdravila po pridobitvi dovoljenja za promet.
English: (Induction and/or inhibition of CYP2C9 by RTV)
Slovenian: (indukcija in/ali inhibicija CYP2C9 z RTV)
English: The apparent volume of distribution of amprenavir following administration of Telzir is approximately 430 l (6 l/kg assuming a 70 kg body weight), suggesting a large volume of distribution, with penetration of amprenavir freely into tissues beyond the systemic circulation.
Slovenian: Navidezni volumen porazdelitve amprenavirja po dajanju zdravila Telzir znaša približno 430 litrov (6 l/kg pri telesni masi 70 kg), kar nakazuje na obsežen volumen porazdelitve in zmožnost prostega prehajanja amprenavirja v tkiva izven sistemskega obtoka.
English: You may get a skin rash.
Slovenian: Pojavi se lahko kožni izpuščaj.
English: Antiviral activity according to genotypic/phenotypic resistance
Slovenian: Protivirusna aktivnost glede na genotipsko/fenotipsko rezistenco
English: Potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Slovenian: Možnost za resne in/ali življenjsko ogrožujoče reakcije, kot npr. srčne aritmije.
English: Due to CYP3A inhibition by Telzir, concentrations of quetiapine are expected to increase.
Slovenian: Zdravilo Telzir zavira CYP3A, zato je treba pričakovati zvišanje koncentracije kvetiapina.
English: Co-administration of paritaprevir and fosamprenavir/ritonavir (FPV/RTV) is contraindicated due to the expected increase of paritaprevir exposure and the lack of clinical data assessing the magnitude of this increase (see section 4.5).
Slovenian: Sočasna uporaba paritaprevirja in fosamprenavirja/ritonavirja (FPV/RTV) je kontraindicirana zaradi pričakovanega povečanja izpostavljenosti paritaprevirju in pomanjkanja kliničnih podatkov o oceni velikosti tega povečanja (glejte poglavje 4.5).
English: Fosamprenavir is converted in man to amprenavir.
Slovenian: Pri človeku fosamprenavir preide v amprenavir.
English: • If you have diabetes.
Slovenian: • Če imate sladkorno bolezen.
English: The incidence of endometrial findings was slightly increased over concurrent controls, but within background range for female rats.
Slovenian: Pojavnost sprememb na maternični sluznici je bila nekoliko večja kot pri sočasnih kontrolah, vendar pa znotraj osnovnih meja za samice podgan.
English: • Increases in enzymes produced by the liver called transaminases, increases of an enzyme produced by the pancreas called lipase.
Slovenian: • Zvišana aktivnost jetrnih encimov, imenovanih transaminaze, zvišana aktivnost encima trebušne slinavke, imenovanega lipaza.
English: Genotypic resistance testing
Slovenian: Genotipsko testiranje rezistence
English: Use with caution (see section 4.4).
Slovenian: Uporabljati s previdnostjo (glejte poglavje 4.4).
English: →Talk to your doctor or pharmacist.
Slovenian: zdravnika ali farmacevta.
English: No drug interaction studies.
Slovenian: Ni študij interakcij zdravil.
English: Important information about ingredients of Telzir oral suspension Telzir oral suspension contains propyl and methyl parahydroxybenzoate.
Slovenian: Pomembne informacije o nekaterih sestavinah Telzir peroralne suspenzije Zdravilo Telzir peroralna suspenzija vsebuje propilparahidroksibenzoat in metilparahidroksibenzoat.
English: No clinically significant interaction is observed.
Slovenian: Klinično signifikantne interakcije niso opažene.
English: It may result in an increase in PDE5 inhibitor associated adverse reactions, including hypotension, visual changes and priapism (refer to PDE5 inhibitor prescribing information).
Slovenian: Lahko povzroči povečanje z inhibitorji PDE5 povezanih stranskih učinkov, vključno s hipotenzijo, vidnimi spremembami in priapismom (glejte informacije za predpisovanje inhibitorjev PDE5).
English: Telzir tablet is administered orally.
Slovenian: Tablete Telzir se uporablja peroralno.
English: No dose recommendations can be given.
Slovenian: Priporočil o odmerku zdravil ne moremo dati.
English: Don't take a double dose to make up for a missed dose.
Slovenian: Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: (Increase in gastric pH)
Slovenian: (povečanje želodčnega pH)
English: Lopinavir / ritonavir 533 mg/133 mg twice daily
Slovenian: lopinavir/ritonavir 533 mg/133 mg dvakrat dnevno
English: ITT (Ext) Population TLOVR analysis
Slovenian: ITT (razširjena) populacija TLOVR analiza
English: • atorvastatin up to 20 mg per day (used to lower cholesterol)
Slovenian: • atorvastatin, v odmerkih do 20 mg na dan (uporabljamo ga za zniževanje vrednosti holesterola)
English: No FPV/RTV drug interaction studies.
Slovenian: Ni FPV/RTV študij interakcij zdravil.
English: As a precaution, patients should be monitored for withdrawal syndrome.
Slovenian: Bolnike pa je kljub temu treba nadzirati glede pojava odtegnitvenega sindroma.
English: As shown in the above table, there were only 16 patients harbouring baseline virus with resistance to FPV/RTV according to the ANRS score.
Slovenian: Kot prikazuje zgornja preglednica, je imelo izhodiščno samo 16 bolnikov, po rezultatu ANRS virus odporen proti FPV/RTV.
English: ViiV Healthcare Trading Services UK Limited 12 Riverwalk,
Slovenian: ViiV Healthcare Trading Services UK Limited
English: Taking Telzir and ritonavir while taking the contraceptive pill may harm your liver and may stop the contraceptive from working properly.
Slovenian: Jemanje zdravila Telzir in ritonavirja skupaj s kontracepcijskimi tabletami lahko škoduje jetrom, učinkovitost kontracepcije pa se lahko zmanjša.
English: Co-administration of fosamprenavir/ritonavir with other antineoplastics metabolised by CYP3A (for example dasatinib, nilotinib, ibrutinib, vinblastine and everolimus) may increase concentrations of these medicinal products, potentially increasing the risk of adverse events usually associated with these agents.
Slovenian: Sočasna uporaba fosamprenavirja/ritonavirja z drugimi antineoplastičnimi učinkovinami, ki se presnavljajo z encimom CYP3A (npr. dasatinib, nilotinib, ibrutinib, vinblastin in everolimus) lahko poveča koncentracije teh zdravil, kar potencialno poveča tveganje za neželene učinke, ki so ponavadi povezani s temi zdravili.
English: After multiple dose oral administration of equivalent fosamprenavir and amprenavir doses, comparable amprenavir AUC values were observed; however, Cmax values were approximately 30 % lower and Cmin values were approximately 28 % higher with fosamprenavir.
Slovenian: Po večkratnem peroralnem dajanju enakovrednih odmerkov fosamprenavirja in amprenavirja so bile opažene primerljive AUC vrednosti amprenavirja, vendar pa so bile po dajanju fosamprenavirja Cmax vrednosti manjše za približno 30 %, Cmin vrednosti pa večje za približno 28 %.
English: One resistance mutation was observed in each of 3 isolates: K20K/R, I54I/L and I93I/L respectively
Slovenian: Pri vsakem od 3 izolatov so poročali o eni rezistenčni mutaciji: K20K/R, I54I/L ali I93I/L.
English: These medicines are not recommended with Telzir/ritonavir:
Slovenian: Zdravila, ki jih ni priporočljivo uporabljati skupaj s kombinacijo Telzir/ritonavir:
English: Autoimmune disorders (such as Graves' disease) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Slovenian: Opisan je bil tudi pojav avtoimunskih bolezni (npr. pojav Gravesove bolezni in avtoimunskega hepatitisa), toda opisani čas do začetka je bolj spremenljiv in ti dogodki se lahko pojavijo veliko mesecev po uvedbi zdravljenja (glejte poglavje 4.4).
English: • If you have haemophilia.
Slovenian: • Če imate hemofilijo.
English: It may cause serious adverse reactions (see section 4.4).
Slovenian: Lahko povzroči resne stranske učinke (glejte poglavje 4.4).
English: It can be treated with antihistamines.
Slovenian: Kožni izpuščaj se lahko zdravi z antihistaminiki.
English: Tablet or Oral suspension 700 mg (1 tablet or 14 ml suspension)
Slovenian: 700 mg (1 tableta ali 14 ml suspenzije)
English: Don't stop Telzir without advice Take Telzir for as long as your doctor recommends.
Slovenian: Zdravila Telzir ne smete prenehati jemati brez zdravnikovega nasveta Zdravilo Telzir jemljite tako dolgo kot vam to svetuje zdravnik.
English: In paediatric patients, the oral suspension should be taken with food in order to aid palatability and assist compliance (see section 5.2).
Slovenian: Pediatrični bolniki morajo peroralno suspenzijo vzeti s hrano za izboljšanje okusa in boljšo sodelovanje (glejte poglavje 5.2).
English: When fosamprenavir and ritonavir are co-administered, the ritonavir metabolic drug interaction profile may predominate because ritonavir is a more potent CYP3A4 inhibitor.
Slovenian: Če se fosamprenavir in ritonavir dajeta sočasno, lahko prevlada presnovni interakcijski profil ritonavirja, saj je ritonavir močnejši zaviralec CYP3A4.
English: Overall, even with these dose adjustments for adults with hepatic impairment, some patients may have higher or lower than anticipated amprenavir and/or ritonavir plasma concentrations as compared to patients with normal hepatic function, due to increased inter-patient variability (see section 5.2), therefore close monitoring of safety and virologic response is warranted.
Slovenian: Gledano v celoti, so zaradi večje variabilnosti med bolniki, kljub takšni prilagoditvi odmerka za odrasle z jetrno okvaro, pri nekaterih bolnikih lahko dosežene višje ali nižje plazemske koncentracije amprenavirja in/ali ritonavirja od pričakovanih, v primerjavi z bolniki, ki imajo normalno jetrno funkcijo (glejte poglavje 5.2), zato je treba te bolnike skrbno nadzirati glede varnosti in virološkega odziva.
English: In children and adolescents the fosamprenavir oral suspension should be taken with food.
Slovenian: Otroci in mladostniki naj peroralno suspenzijo fosamprenavirja jemljejo s hrano.
English: Telzir helps to control your condition, but it is not a cure for HIV infection.
Slovenian: Zdravilo Telzir pomaga nadzirati bolezen, vendar pa okužbe z virusom HIV ne more ozdraviti.
English: Don't take other medicines for the infection without your doctor's advice.
Slovenian: Brez zdravnikovega nasveta ne jemljite drugih zdravil za zdravljenje okužb.
English: Didanosine chewable tablet No drug interaction studies.
Slovenian: didanozin žvečljive tablete Ni študij interakcij zdravil.
English: Children and adolescent patients above the age of six
Slovenian: Otroci in mladostniki, starejši od 6 let
English: Not recommended.
Slovenian: Ni priporočljivo.
English: Capsule or Solution
Slovenian: Kapsula ali raztopina
English: • carbamazepine, phenobarbital, phenytoin (used to treat epilepsy)
Slovenian: • karbamazepin, fenobarbital, fenitoin (uporabljamo jih za zdravljenje epilepsije)
English: (Telzir 1400 mg twice daily)
Slovenian: (Telzir 1400 mg dvakrat dnevno)
English: Concomitant use of Telzir with ritonavir and fluticasone or other glucocorticoids that are metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression (see section
Slovenian: Sočasne uporabe zdravila Telzir v kombinaciji z ritonavirjem in flutikazonom ali drugimi glukokortikoidi, ki se presnavljajo s CYP3A4, ne priporočamo, razen v primerih, ko možne koristi zdravljenja prevladajo nad tveganjem za pojav sistemskih kortikosteroidnih učinkov, vključno s Cushingovim sindromom in z zaviralnim vplivom na nadledvično žlezo (glejte poglavje 4.5).
English: In the Time to loss of virological response (TLOVR) analysis for the ITT(E) population, the proportion of patients achieving <400 copies/ml was 73 % (315 / 434) in the fosamprenavir with ritonavir group compared to 71 % (317 / 444) of patients receiving lopinavir / ritonavir, with a 95 % confidence interval of the difference of [-4,84%; 7;05%].
Slovenian: Analize časa do izgube virološkega odziva (TLOVR - »Time to loss of virological response«) pri vseh vključenih/izpostavljenih bolnikih (ITT(E) - »intent to treat«) kažejo, da je bila v skupini, ki je prejemala fosamprenavir skupaj z ritonavirjem, vrednost < 400 kopij/ml dosežena pri 73 % bolnikov (315/434), v skupini, ki je prejemala kombinacijo lopinavir/ritonavir, pa pri 71 % bolnikov (317/444); 95 % interval zaupanja [-4,84 %; 7,05 %].
English: The pack also includes a polyethylene syringe-adapter and a 10 ml oral dosing syringe comprised of a polypropylene barrel (with ml graduations) and a polyethylene plunger.
Slovenian: V škatli je priložen tudi polietilenski nastavek za brizgo in 10 ml odmerna brizga, ki je sestavljena iz polipropilenske cevi (z ml lestvico) in polietilenskega bata.
English: (Read the package leaflet of Telzir oral suspension for guidance on whether to take it with or without food.)
Slovenian: (Za navodila za uporabo Telzir peroralne suspenzije skupaj s hrano ali brez nje glejte navodila za uporabo Telzir peroralne suspenzije.)
English: In rabbits, systemic exposure at the high dose level was only 0.3 times human exposure at the maximum clinical dose and thus the developmental toxicity of fosamprenavir has not been fully determined.
Slovenian: Sistemska izpostavljenost kuncev po največjem odmerku je bila enaka le 0,3-kratni izpostavljenosti pri človeku po največjem kliničnem odmerku in tako škodljiv vpliv fosamprenavirja na razvoj ni bil podrobno preučen.
English: • halofantrine (used to treat malaria)
Slovenian: • halofantrin (uporabljamo ga za zdravljenje malarije)
English: APV geometric mean (95% CI) and Ctau values were 1.31 (0.97, 1.77), 1.34 (0.95, 1.89), and 2.03 (1.46, 2.83) µg/mL for the second trimester, third trimester, and postpartum, respectively and within the range of values in non-pregnant patients on the same FPV/RTV containing regimens.
Slovenian: Geometrična sredina (95 % IZ) in vrednost Ctau APV sta bili v drugem trimesečju 1,31 µg/ml (0,97; 1,77), v tretjem trimesečju 1,34 µg/ml (0,95; 1,89) in po porodu 2,03 µg/ml (1,46; 2,83) ter znotraj razpona vrednosti, ugotovljenega pri nenosečih ženskah, ki so prejemale enak režim s FPV/RTV.
English: The most frequently (> 5% of adult subjects treated) reported adverse reactions with fosamprenavir/ritonavir combination were gastrointestinal reactions (nausea, diarrhoea, abdominal pain and vomiting) and headache.
Slovenian: Najpogostejši neželeni učinki (zabeleženi pri > 5 % zdravljenih odraslih) pri kombiniranem zdravljenju s fosmaprenavirjem/ritonavirjem so bili učinki na prebavila (navzea, driska, bolečine v trebuhu in bruhanje) in glavobol.
English: What Telzir looks like and contents of the pack
Slovenian: Izgled zdravila Telzir in vsebina pakiranja
English: Adults with liver disease
Slovenian: Odrasli z boleznijo jeter
English: If you are pregnant, think you may be pregnant, or are planning to have a baby: →Ask your doctor or pharmacist for advice before taking this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseče ali načrtujete zanositev: →Posvetujte se s svojim zdravnikom ali s farmacevtom o tveganjih in koristih zdravljenja z zdravilom Telzir.
English: HDPE bottles with a child resistant polypropylene closure containing 60 tablets.
Slovenian: Plastenke iz polietilena visoke gostote (HDPE) z za otroke varno polipropilensko zaporko, ki vsebujejo 60 tablet.
English: No dose adjustment is considered necessary in patients with renal impairment (see section 5.2).
Slovenian: Smatra se, da pri bolnikih z okvaro ledvic odmerka ni potrebno prilagoditi (glejte poglavje 5.2).
English: Adverse reaction
Slovenian: Neželene reakcije
English: The use of Telzir concomitantly with halofantrine or lidocaine (systemic) is not recommended.
Slovenian: Zdravila Telzir ni priporočljivo uporabljati sočasno s halofantrinom ali z lidokainom (sistemskim).
English: The conversion of fosamprenavir to amprenavir appears to primarily occur in the gut epithelium.
Slovenian: Do pretvorbe fosamprenavirja v amprenavir dozdevno pride predvsem v epiteliju črevesja.
English: If you notice any muscle problems: →Tell your doctor.
Slovenian: Če se pojavijo kakršnekoli težave z mišicami: →Obvestite svojega zdravnika.
English: After oral administration, fosamprenavir is rapidly and almost completely hydrolysed to amprenavir and inorganic phosphate prior to reaching the systemic circulation.
Slovenian: Po peroralnem vnosu se fosamprenavir, še preden doseže sistemski obtok, hitro in skoraj popolnoma hidrolizira v amprenavir in anorganski fosfat.
English: Children and adolescents should take the Telzir oral suspension with food.
Slovenian: Otroci in mladostniki morajo zdravilo Telzir peroralna suspenzija jemati skupaj s hrano.
English: Frequent therapeutic concentration monitoring of immunosuppressant levels is recommended until levels have stabilised (see section
Slovenian: Priporočljivo je, da se terapevtske koncentracije zdravil za zaviranje imunske odzivnosti do njihove stabilizacije pogosto nadzirajo (glejte poglavje
English: It is therefore important that you carefully read the package leaflet provided with these medicines.
Slovenian: Pomembno je, da natančno preberete vsa zdravilom priložena navodila za uporabo.
English: ITT (Ext) Observed analysis
Slovenian: ITT (razširjena) opazovana analiza
English: In protease inhibitor (PI) experienced patients, the choice of Telzir should be based on individual viral resistance testing and treatment history (see section 5.1).
Slovenian: Pri bolnikih, ki so predhodno že bili zdravljeni z zaviralcem proteaz (PI), mora izbira zdravila Telzir temeljiti na individualnem testiranju virusne rezistence in podatkih predhodnega zdravljenja bolnikov (glejte poglavje 5.1).
English: Alternative non-hormonal methods of contraception are recommended for women of childbearing potential (see section 4.4).
Slovenian: Pri ženskah v rodni dobi je priporočljiva uporaba alternativnih nehormonskih kontracepcijskih metod (glejte poglavje 4.4).
English: • lopinavir/ritonavir combination (used to treat HIV infection)
Slovenian: • kombinacija lopinavir/ritonavir (uporabljamo jo za zdravljenje okužbe z virusom HIV)
English: Genotypic Sensitivity Score in OBT
Slovenian: Rezultat genotipske občutljivosti pri OBT
English: In animal studies at systemic plasma exposures (AUC) to amprenavir lower than therapeutic exposure in patients treated with Telzir, some developmental toxicity was observed (see section 5.3).
Slovenian: Pri študijah na živalih so pri sistemski plazemski izpostavljenosti amprenavirju, ki je bila manjša od terapevtske izpostavljenosti pri bolnikih, ki se zdravijo z zdravilom Telzir, opazili določene razvojne toksične učinke (glejte poglavje 5.3).
English: Concomitant use of Telzir with simvastatin or lovastatin is contraindicated because of increased plasma concentrations of lovastatin and simvastatin which can increase the risk of myopathy, including rhabdomyolysis (see section 4.5).
Slovenian: Sočasna uporaba zdravila Telzir in simvastatina ali lovastatina je kontraindicirana zaradi višjih plazemskih koncentracij lovastatina in simvastatina, ki lahko povečajo tveganje za miopatijo, vključno z rabdomiolizo (glejte poglavje 4.5).
English: You must take Telzir oral suspension.
Slovenian: Uporabiti morate zdravilo Telzir peroralna suspenzija.
English: Ketoconazole: Cmax ↑ 25% Ketoconazole: AUC ↑ 2.69fold.
Slovenian: ketokonazol: Cmax  25% ketokonazol: AUC  2.69-krat.
English: MARKETING AUTHORISATION NUMBER EU/1/04/282/002
Slovenian: ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/04/282/002
English: In rats, there was no major effect on fertillty or reproductive performance with fosamprenavir (see section 5.3).
Slovenian: Uporaba fosamprenavirja pri podganah ni imela večjega vpliva na plodnost ali sposobnost razmnoževanja (glejte poglavje 5.3).
English: Any unused medicinal product should be disposed of in accordance with local requirements.
Slovenian: Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
English: In reproductive toxicity studies with fosamprenavir in rats, male fertility was not affected.
Slovenian: Študije vplivov fosamprenavirja na sposobnost razmnoževanja podgan so pokazale, da plodnost samcev ni bila prizadeta.
English: Telzir must only be given with low dose ritonavir as a pharmacokinetic enhancer of amprenavir and in combination with other antiretroviral medicinal products.
Slovenian: Zdravilo Telzir se sme dajati le skupaj z nizkim odmerkom ritonavirja, ki stopnjuje farmakokinetične lastnosti amprenavirja, in v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: Telzir is to be taken in combination with low doses of ritonavir and other antiretroviral medicines.
Slovenian: Zdravilo Telzir morate jemati v kombinaciji z nizkimi odmerki ritonavirja in z drugimi protiretrovirusnimi zdravili.
English: Autoimmune disorders (such as Graves' disease) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and can occur many months after initiation of treatment.
Slovenian: V okviru imunske reaktivacije je bil opisan tudi pojav avtoimunskih bolezni (npr. pojav Gravesove bolezni in avtoimunskega hepatitisa), toda opisani čas do začetka je bolj spremenljiv in se lahko pojavi veliko mesecev po uvedbi zdravljenja.
English: Telzir with low doses of ritonavir is used in combination with other anti-retroviral medicines (‘combination therapy') to treat adults, adolescents and children aged over 6 years infected with HIV.
Slovenian: Zdravilo Telzir z nizkimi odmerki ritonavirja uporabljamo v kombinaciji z drugimi protiretrovirusnimi zdravili (‘kombinirano zdravljenje') za zdravljenje okužbe z virusom HIV pri odraslih, mladostnikih in otrocih, starejših od 6 let.
English: Careful monitoring of the therapeutic and adverse reactions of tricyclic antidepressants is recommended (see section
Slovenian: V primeru zdravljenja s tricikličnimi antidepresivi je priporočljivo, da se terapevtske in neželene reakcije tricikličnih antidepresivov skrbno nadzirajo (glejte poglavje
English: If a patient is already taking St John's wort, check amprenavir, ritonavir and HIV RNA and stop St John's wort.
Slovenian: Če bolnik že jemlje pripravke, ki vsebujejo šentjanževko, je potrebno preveriti vrednosti amprenavirja, ritonavirja in HIV RNA ter prenehati jemati pripravke, ki vsebujejo šentjanževko.