FrancophonIA/ELRC3.0 huggingface dataset:
English: Treatment-emergent major protease or APV-associated mutations were observed in virus isolated from 1 patient in APV29005 and 6 patients from APV20003.
Slovenian: Med zdravljenjem nastale pomembne ali z APV- povezane proteazne mutacije so opazili pri virusih, izoliranih od 1 bolnika v APV29005 in od 6 bolnikov v APV20003.
English: Drug-related adverse reactions were more common in APV20003 (57%) where subjects received once daily fosamprenavir / ritonavir when compared to APV29005 (33%) where subjects received twice daily fosamprenavir / ritonavir.
Slovenian: Z zdravili povezani neželeni učinki so bili pogostejši v študiji APV20003 (57 %), v kateri so bolniki prejemali fosamprenavir/ritonavir enkrat na dan, kot v študiji APV29005 (33 %), v kateri so fosamprenavir/ritonavir prejemali dvakrat na dan.
English: The rash generally will resolve spontaneously without the necessity of discontinuing treatment with the fosamprenavir with ritonavir.
Slovenian: Na splošno je prišlo do spontane resolucije eksantema, ne da bi bilo potrebno zdravljenje s fosamprenavirjem v kombinaciji z ritonavirjem opustiti.
English: Telzir must not be administered concurrently with medicinal products with narrow therapeutic windows that are substrates of cytochrome P450 3A4 (CYP3A4), e.g. alfuzosin, amiodarone, astemizole, bepridil, cisapride, dihydroergotamine, ergotamine, pimozide, quetiapine, quinidine, terfenadine, oral midazolam (for caution on parenterally administered midazolam, see section 4.5), oral triazolam, sildenafil used for the treatment of pulmonary arterial hypertension (for use of sildenafil in patients with erectile dysfunction, see sections 4.4 and 4.5).
Slovenian: Zdravilo Telzir se ne sme uporabljati sočasno z zdravili ozke terapevtske širine, ki so substrat za citokrom P450 3A4 (CYP3A4), npr. z alfuzosinom, amiodaronom, astemizolom, bepridilom, s cisapridom, z dihidroergotaminom, ergotaminom, pimozidom, s kvetiapinom, kinidinom, terfenadinom, peroralno obliko midazolama (glede previdnostnih ukrepov ob parenteralni uporabi midazolama glejte poglavje 4.5), peroralno obliko triazolama, sildenafilom, ki se uporablja za zdravljenje pljučne arterijske hipertenzije (za uporabo sildenafila pri bolnikih z erektilno disfunkcijo glejte poglavji 4.4 in 4.5).
English: Protease Inhibitors:
Slovenian: Zaviralci proteaz:
English: FPV/RTV BID - Fosamprenavir with ritonavir twice daily, LPV/RTV BID - Lopinavir / ritonavir twice daily
Slovenian: FPV/RTV 2x/dan - fosamprenavir z ritonavirjem dvakrat na dan, LPV/RTV 2x/dan - lopinavir/ritonavir dvakrat na dan
English: Turn the bottle the right way up and remove the syringe from the adapter.
Slovenian: Plastenko obrnite pokonci in odmerno brizgo odstranite iz plastičnega nastavka.
English: The primary route of metabolism is via the cytochrome P450 3A4 enzyme.
Slovenian: Primarna presnovna pot poteka preko encima citokrom P450 3A4.
English: However, the bioequivalence could not be demonstrated when the oral suspension was given with food.
Slovenian: Vendar, pri dajanju peroralne suspenzije skupaj s hrano, bioekvivalence ni bilo mogoče dokazati.
English: Additionally, both amprenavir, the active metabolite of fosamprenavir, and ritonavir are primarily metabolised in the liver by CYP3A4.
Slovenian: Oba, tako amprenavir, ki je aktivni presnovek fosamprenavirja, kot ritonavir, se primarno presnavljata v jetrih s CYP3A4.
English: Repeat dose studies with fosamprenavir in rats produced effects consistent with hepatic enzyme induction, which predisposes rats to thyroid neoplasms.
Slovenian: Pri študijah s ponavljajočimi se odmerki fosamprenavirja pri podganah so ugotovili učinke, ki so bili v skladu z indukcijo jetrnih encimov, kar pri podganah povzroča nagnjenost k pojavu ščitničnih tumorjev.
English: Telzir dose (TWICE DAILY)
Slovenian: Odmerek zdravila Telzir (DVAKRAT NA DAN)
English: Ritonavir AUC12 ↓ 0.66 Ritonavir Cmax ↓ 0.61 Ritonavir C12 ↔ 0.86
Slovenian: AUC12  0,66 ritonavir: Cmax  0,61 ritonavir: C12 ↔ 0,86
English: • If you have liver disease.
Slovenian: • Če imate bolezen jeter.
English: • Feeling sick or being sick (nausea or vomiting), pain in the stomach, loose stools
Slovenian: • Siljenje na bruhanje (navzea) ali bruhanje, bolečina v trebuhu, neredno odvajanje blata.
English: mechanism of interaction is CYP3A4 inhibition by fosamprenavir/ritonavir.
Slovenian: Mehanizem interakcije je inhibicija CYP3A4 s fosamprenavirjem/ritonavirjem.
English: If you get any symptoms of infection or signs of inflammation while you're taking Telzir: →Tell your doctor immediately.
Slovenian: Če med jemanjem zdravila Telzir opazite katerikoli simptom okužbe ali znak vnetja: →Nemudoma obvestite svojega zdravnika.
English: If this happens to you: →Talk to your doctor immediately.
Slovenian: V tem primeru: →Nemudoma se posvetujte s svojim zdravnikom.
English: Hypromellose Titanium dioxide (E171) Glycerol triacetate Iron oxide red (E172)
Slovenian: Filmska obloga tablete: hipromeloza titanov dioksid (E171) triacetin rdeči železov oksid (E172)
English: Patients on stable dose of paroxetine who start treatment with Telzir and ritonavir should be monitored for antidepressant response.
Slovenian: Pri bolnikih, ki se že zdravijo s stabilnim odmerkom paroksetina in se jim dodatno uvede še zdravljenje z zdravilom Telzir in ritonavirjem, je treba nadzirati antidepresivni odziv.
English: Telzir 700 mg film-coated tablets Fosamprenavir
Slovenian: Telzir 700 mg filmsko obložene tablete fosamprenavir
English: Clinical chemistry abnormalities: clinical chemistry abnormalities (Grade 3 or 4) potentially related to treatment with fosamprenavir with ritonavir and reported in greater than or equal to 1 % of adult patients, included: increased ALT (common), AST (common), serum lipase (common) and triglycerides (common).
Slovenian: Odstopanja kliničnih biokemičnih parametrov: Odstopanja kliničnih biokemičnih parametrov (stopnje 3 ali 4), ki bi lahko bila vezana na zdravljenje s fosamprenavirjem v kombinaciji z ritonavirjem in o katerih so poročali pri 1 % odraslih bolnikov ali več, vključujejo: zvišanje vrednosti ALT (pogosto), AST (pogosto), serumske lipaze (pogosto) in trigliceridov (pogosto).
English: This product also contains preservatives: methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216), see leaflet for further information
Slovenian: To zdravilo vsebuje tudi konzervanse: metilparahidroksibenzoat (E218) in propilparahidroksibenzoat (E216), za dodatne informacije glejte navodilo.
English: Rat pups exposed pre and post-natally to amprenavir and fosamprenavir showed developmental toxicity (see section 5.3).
Slovenian: Podganji mladiči, ki so bili pre- in postnatalno izpostavljeni amprenavirju in fosamprenavirju, so kazali znake razvojnih toksičnih učinkov (glejte poglavje 5.3).
English: Telzir tablet and oral suspension formulations, both given fasted, delivered equivalent plasma amprenavir AUC∞ values and the Telzir oral suspension formulation delivered a 14 % higher plasma amprenavir Cmax as compared to the oral tablet formulation.
Slovenian: Po dajanju zdravila Telzir na tešče, bodisi tablet bodisi peroralne suspenzije, so si vrednosti AUC amprenavirja v plazmi enakovredne, v primerjavi z dajanjem zdravila Telzir v obliki tablet pa je po dajanju peroralne suspenzije Cmax amprenavirja v plazmi za 14 % večja.
English: Discard 28 days after first opening.
Slovenian: 2 leti 28 dni po prvem odprtju zdravilo zavrzite.
English: Amprenavir is primarily metabolised by the liver with less than 1 % excreted unchanged in the urine.
Slovenian: Amprenavir se primarno presnavlja v jetrih, manj kot 1 % se ga v nespremenjeni obliki izloči z urinom.
English: If you have taken more than the prescribed dose of Telzir: →Contact your doctor or pharmacist immediately for advice.
Slovenian: Če ste vzeli prevelik odmerek zdravila Telzir Če ste vzeli odmerek zdravila Telzir, večji od predpisanega: →Nemudoma se posvetujte z zdravnikom ali s farmacevtom.
English: This dose adjustment cannot be made with Telzir tablets.
Slovenian: Odmerka ne smete prilagoditi s zdravilom Telzir tablete.
English: How to take Telzir
Slovenian: Kako jemati zdravilo Telzir
English: Indinavir Saquinavir
Slovenian: indinavir sakvinavir
English: PDE5 inhibitors used for the treatment of erectile dysfunction: The use of Telzir concomitantly with PDE5 inhibitors (e.g. sildenafil, tadalafil, vardenafil) is not recommended (see section 4.5).
Slovenian: Zaviralci PDE5, ki se uporabljajo za zdravljenje erektilne disfunkcije: Zdravila Telzir ni priporočljivo uporabljati sočasno z zaviralci fosfodiesteraze tipa 5 (PDE5) (npr. s sildenafilom,, tadalafilom, z vardenafilom) (glejte poglavje 4.5).
English: Haemophiliac patients: there have been reports of increased spontaneous bleeding in haemophiliac patients receiving antiretroviral protease inhibitors (see section 4.4).
Slovenian: Bolniki s hemofilijo: Opisani so primeri številnejših spontanih krvavitev pri bolnikih s hemofilijo, ki so prejemali protiretrovirusne zaviralce proteaz (glejte poglavje 4.4).
English: Treatment-emergent major or APV-associated protease mutations were observed in virus isolated from 2 patients.
Slovenian: Med zdravljenjem nastale pomembne ali z APVpovezane proteazne mutacije so opazili pri virusih, izoliranih od 2 bolnikov.
English: Shake the bottle for 20 seconds before the first use.
Slovenian: Pred prvo uporabo plastenko stresajte 20 sekund.
English: In the paediatric studies APV20003 and APV29005, 77 PI-experienced patients were treated with fosamprenavir / ritonavir-based regimens and 43 patients met study-defined virologic failure criteria through 48 weeks in APV29005 and up to 108 weeks in APV20003.
Slovenian: V pediatričnih študijah APV20003 in APV29005 je 77 bolnikov, predhodno že zdravljenih z zaviralci proteaz, prejemalo sheme na podlagi kombinacije fosamprenavir/ritonavir; pri 43 bolnikih je prišlo do virusnega neodziva po merilih, opredeljenih v študiji, do 48. tedna v APV29005 in do 108. tedna v APV20003.
English: Flecainide: ↑ expected Propafenone: ↑ expected
Slovenian: flekainide:  pričakovano propafenon:  pričakovano
English: Table 4 AAUCMB at Week 48 by genotypic sensitivity score in OBT and baseline resistance to FPV/RTV
Slovenian: Preglednica 4: 48. teden po rezultatu genotipske občutljivosti (GSS) pri OBT in izhodiščna odpornost proti FPV/RTV
English: Key: 1GSS to OBT: Genotypic Sensitivity Score to Optimised Background.
Slovenian: 1GSS pri OBT: rezultat genotipske občutljivosti (GSS-Genotypic Sensitivity Score) pri optimiziranem osnovnem zdravljenju (OBT- Optimised Background).
English: Concomitant administration of fosamprenavir /ritonavir with lurasidone is contraindicated due to the potential for serious and/or life-threatening reactions related to lurasidone (see section 4.3)
Slovenian: Sočasna uporaba fosamprenavirja/ritonavirj a z lurazidonom je kontraindicirana zaradi možnosti za resne in/ali življenjsko ogrožujoče reakcije, povezane z lurazidonom (glejte poglavje 4.3).
English: The primary route of elimination of amprenavir is via hepatic metabolism with less than 1 % excreted unchanged in the urine and no detectable amprenavir in faeces.
Slovenian: Poglavitna pot izločanja amprenavirja poteka preko presnove v jetrih, pri čemer se ga v nespremenjeni obliki z urinom izloči manj kot 1 %, v blatu pa takšna oblika ni dokazljiva.
English: • doses of atorvastatin greater than 20 mg per day (used to lower cholesterol)
Slovenian: • odmerki atorvastatina, večji od 20 mg na dan (uporabljamo jih za zniževanje vrednosti holesterola)
English: Similarily, administration of fosamprenavir with ritonavir may modify the pharmacokinetics of other active substances that share this metabolic pathway.
Slovenian: Podobno lahko tudi dajanje fosamprenavirja v kombinaciji z ritonavirjem spremeni farmakokinetične lastnosti drugih učinkovin, ki si delijo to presnovno pot.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse reactions.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki se zdravijo s kombiniranim protiretrovirusnim zdravljenjem, obstaja veliko tveganje za pojav hudih in potencialno usodnih neželenih učinkov, povezanih z jetri.
English: • injectable midazolam (used to treat anxiety)
Slovenian: • injiciran midazolam (uporabljamo ga za zdravljenje tesnobe)
English: HDPE bottle with a child resistant polypropylene closure containing 225 millilitres oral suspension.
Slovenian: Plastenke iz polietilena visoke gostote (HDPE) z za otroke varno polipropilensko zaporko, ki vsebujejo 225 ml peroralne suspenzije.
English: The principal route of amprenavir and ritonavir elimination is hepatic metabolism.
Slovenian: Glavna pot izločanja amprenavirja in ritonavirja je jetrna presnova.
English: Children can take the adult dose of ritonavir capsules (100 mg twice daily) if they weigh at least 33 kg and can swallow the capsules whole.
Slovenian: Otroci lahko jemljejo odmerek ritonavir kapsul za odrasle (100 mg dvakrat na dan), če imajo telesno maso vsaj 33 kg in lahko kapsulo pogoltnejo celo.
English: • cyclosporin, rapamycin, tacrolimus (used to suppress the immune system)
Slovenian: • ciklosporin, rapamicin, takrolimus (uporabljamo jih za zaviranje imunskega sistema)
English: ANTIHISTAMINES (HISTAMINE H1 RECEPTOR ANTAGONISTS) Astemizole Terfenadine
Slovenian: ANTIHISTAMINIKI (ANTAGONISTI HISTAMINSKIH RECEPTORJEV H1)
English: Because there may be an increased risk of hepatic transaminase elevations and hormonal levels may be altered with co-administration of fosamprenavir, ritonavir and oral contraceptives, alternative nonhormonal methods of contraception are recommended for women of childbearing potential (see section 4.5).
Slovenian: Pri sočasni uporabi fosamprenavirja, ritonavirja in peroralnih kontraceptivov obstaja večje tveganje za povišanje jetrnih transaminaz in spremembo vrednosti hormonov, zato je pri ženskah v rodni dobi priporočljiva uporaba alternativnih nehormonskih kontracepcijskih metod (glejte poglavje 4.5).
English: No data are available on the co-administration of fosamprenavir and ritonavir with oestrogens and/or progestogens when used as hormonal replacement therapies.
Slovenian: Podatki o sočasni uporabi fosamprenavirja in ritonavirja ter estrogenov in/ali progestogenov v sklopu hormonskega nadomestnega zdravljenja niso na voljo.
English: INHALED/NASAL STEROIDS
Slovenian: INHALACIJSKI NAZALNI KORTIKOSTEROIDI
English: Immune Reactivation Syndrome: in HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Slovenian: Sindrom imunske reaktivacije: Pri s HIV okuženih bolnikih s hudo imunsko pomanjkljivostjo lahko ob uvedbi kombiniranega protiretrovirusnega zdravljenja (CART - "combination antiretroviral therapy") nastane vnetna reakcija na asimptomatične ali rezidualne oportunistične okužbe.
English: The relevance of the uterine endometrial adenocarcinomas for humans is uncertain; however there is no evidence from clinical trials or marketed use to suggest that these findings are of clinical significance.
Slovenian: Pomen adenokarcinomov na maternični sluznici za človeka ni pojasnjen, vendar pa med kliničnimi preskušanji ali med uporabo zdravila po pridobitvi dovoljenja za promet ni bilo znakov, ki bi kazali, da imajo te ugotovitve klinični pomen.
English: Shake the bottle vigorously for 20 seconds before first dose is removed and 5 seconds before each subsequent dose.
Slovenian: Pred odvzemom prvega odmerka iz plastenke, je le to potrebno dobro pretresati 20 sekund, pred nadaljnjimi uporabami pa 5 sekund.
English: A MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE Name and address of the manufacturers responsible for batch release Film-coated tablets
Slovenian: Ime in naslov izdelovalca, odgovornega za sproščanje serije Filmsko obložene tablete
English: Herbal preparations containing St John's wort must not be combined with Telzir (see section 4.3).
Slovenian: Rastlinskih pripravkov, ki vsebujejo šentjanževko, se ne sme kombinirati z zdravilom Telzir (glejte poglavje 4.3).
English: Less than 1 % of the therapeutic dose of amprenavir is excreted unchanged in the urine.
Slovenian: Z urinom se v nespremenjeni obliki izloči manj kot 1 % terapevtskega odmerka amprenavirja.
English: Among the 81 PI-naïve paediatric patients treated with fosamprenavir / ritonavir, 15 patients met protocol-defined virological failure through 48 weeks in APV29005 and up to 108 weeks in APV20003.
Slovenian: Med 81 pediatričnimi bolniki, ki se še niso zdravili z zaviralci proteaz in so bili zdravljeni s kombinacijo fosamprenavir/ritonavir, se je pri 15 pojavil v protokolu opredeljen virusni neodziv do 48. tedna v APV29005 in do 108. tedna v APV20003.
English: Hepatitis C virus (HCV) Direct-Acting Antivirals: When hepatitis C virus direct-acting antiviral (DAA) drugs, which are metabolised by CYP3A4 or are inducers/inhibitors of CYP3A4, are coadministered with fosamprenavir/ritonavir, altered plasma concentrations of medications are expected due to inhibition or induction of CYP3A4 enzyme activity (see section 4.3 and 4.5).
Slovenian: Protivirusna zdravila proti virusu hepatitisa C (HCV) z neposrednim delovanjem: Če so sočasno s fosamprenavirjem/ritonavirjem uporabljena protivirusna zdravila proti virusu hepatitisa C z neposrednim delovanjem (DAA - direct-acting antivirals), ki se presnavljajo s CYP3A4 ali so induktorji/zaviralci CYP3A4, se zaradi zavrtja ali indukcije encimske aktivnosti CYP3A4 pričakuje spremenjena koncentracija zdravil v plazmi (glejte poglavji 4.3 in 4.5).
English: No dosing recommendations can be made for the very young (children < 2 years of age) and Telzir with ritonavir is not recommended for this patient population (see section 4.2).
Slovenian: Za zelo mlade otroke (mlajše od 2 let) priporočil za odmerjanje ni in zdravilo Telzir v kombinaciji z ritonavirjem za to populacijo ni primerno (glejte poglavje 4.2).
English: Telzir tablets may be taken without regard to food intake.
Slovenian: Tablete Telzir se lahko jemljejo ne glede na obroke hrane.
English: In pregnant rats and rabbits there were no major effects on embryo-foetal development.
Slovenian: Pri brejih podganah in kunčjih samicah ni bil opažen pomembnejši vpliv na embriofetalni razvoj, število abortusov pa je bilo večje.
English: Co-administration of Telzir 700 mg twice daily with ritonavir in doses greater than 100 mg twice daily has not been clinically evaluated.
Slovenian: Sočasno dajanje zdravila Telzir v odmerku 700 mg dvakrat dnevno v kombinaciji z ritonavirjem v odmerkih višjih od 100 mg dvakrat dnevno ni bilo klinično ovrednoteno.
English: Telzir is also available as 700 mg film-coated tablets.
Slovenian: Zdravilo Telzir je na voljo tudi v obliki 700 mg filmsko obloženih tablet.
English: Co-administration of Telzir with low dose ritonavir and these medicinal products is expected to substantially increase their concentrations and may result in PDE5 inhibitor-associated adverse events such as hypotension, visual changes and priapism (see section 4.5).
Slovenian: Pričakovati je, da sočasna uporaba zdravila Telzir z majhnimi odmerki ritonavirja in teh zdravil bistveno poveča njihovo koncentracijo in lahko povzroči z zaviralci PDE5 povezane neželene učinke, npr. hipotenzijo, motnje vida in priapizem (glejte poglavje 4.5).
English: Geometric mean change
Slovenian: Povprečna geometrična sprememba
English: Some people taking combination therapy for HIV develop a condition called osteonecrosis.
Slovenian: Pri nekaterih bolnikih se med kombiniranim zdravljenjem okužbe z virusom HIV lahko pojavi stanje, imenovano osteonekroza.
English: - alfuzosin (used to treat a prostate problem) - astemizole or terfenadine (commonly used to treat allergy symptoms - these medicines may be available without prescription) - pimozide (used to treat schizophrenia) - quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder) - lurasidone (used to treat schizophrenia and bipolar disorder) - cisapride (used to relieve indigestion) - ergot derivatives (used to treat headaches) - rifampicin (used to treat tuberculosis) - amiodarone, quinidine, flecainide and propafenone (heart medicines) - bepridil (used to treat high blood pressure) - oral midazolam or oral triazolam (used to treat anxiety) - products containing St John's wort (Hypericum perforatum) - lovastatin, simvastatin (used to lower cholesterol) - sildenafil if used to treat pulmonary arterial hypertension, (a condition affecting the blood vessels to your lungs) - paritaprevir (used to treat hepatitis C virus infection)
Slovenian: • če jemljete katero od navedenih zdravil: - alfuzosin (uporabljamo ga za zdravljenje bolezni prostate) - astemizol ali terfenadin (pogosto ju uporabljamo za zdravljenje simptomov alergije - ti zdravili sta lahko na voljo tudi brez recepta) - pimozid (uporabljamo ga za zdravljenje shizofrenije) - kvetiapin (uporabljamo ga za zdravljenje shizofrenije, bipolarne motnje in velike depresije) - lurazidon (uporabljamo ga za zdravljenje shizofrenije in bipolarne motnje) - cisaprid (uporabljamo ga za lajšanje prebavnih težav) - ergot derivati (uporabljamo jih za zdravljenje glavobolov) - rifampicin (uporabljamo ga za zdravljenje tuberkuloze) - amiodaron, kinidin, flekainid in propafenon (zdravila za zdravljenje bolezni srca) - bepridil (uporabljamo ga za zdravljenje visokega krvnega tlaka) - peroralni midazolam ali peroralni triazolam (uporabljamo ju za zdravljenje tesnobe) - pripravki, ki vsebujejo šentjanževko (Hypericum perforatum) - lovastatin, simvastatin (uporabljamo ju za zniževanje vrednosti holesterola) - sildenafil, če se uporablja za zdravljenje pljučne arterijske hipertenzije, (bolezni, ki prizadene pljučne žile) - paritaprevir (uporabljamo ga za zdravljenje okužbe z virusom hepatitisa C)
English: Administration of the fosamprenavir tablet formulation in the fed state (standardised high fat meal: 967 kcal, 67 grams fat, 33 grams protein, 58 grams carbohydrate) did not alter plasma amprenavir pharmacokinetics (Cmax, tmax or AUC0-∞) compared to the administration of this formulation in the fasted state.
Slovenian: Dajanje fosamprenavirja v obliki tablet po obroku (standardiziran obrok z veliko vsebnostjo maščob: 967 kcal, 67 g maščobe, 33 g beljakovin, 58 g ogljikovih hidratov) v primerjavi z dajanjem tablet na tešče ni spremenilo farmakokinetičnih lastnosti amprenavirja (Cmax, Tmax ali AUC0-).
English: Turn the bottle upside down.
Slovenian: Plastenko obrnite na glavo.
English: By stopping protease from working, Telzir stops HIV multiplying and infecting more CD4 cells.
Slovenian: Zdravilo Telzir prekine delovanje proteaze in s tem ustavi razmnoževanje virusa HIV ter prepreči okužbo dodatnih celic CD4.
English: 1000 - 10,000 copies/ml >10,000 - 100,000 copies/ml >100,000 copies/ml AAUCMB Observed Analysis
Slovenian: 1.000 - 10.000 kopij/ml >10.000 - 100.000 kopij/ml >100,000 kopij/ml
English: Telzir 50 mg/ml oral suspension Fosamprenavir
Slovenian: Telzir 50 mg/ml peroralna suspenzija fosamprenavir
English: Co-administration of the antipsychotic medicinal product lurasidone and fosamprenavir/ritonavir (FPV/RTV) is contraindicated (see section 4.5).
Slovenian: Sočasna uporaba antipsihotika lurazidona in fosamprenavirja/ritonavirja (FPV/RTV) je kontraindicirana (glejte poglavje 4.5).
English: Predicted exposures are based on extrapolation from data observed following administration of fosamprenavir 300 mg twice daily with ritonavir 100 mg once daily in subjects with moderate hepatic impairment.
Slovenian: Predvidene izpostavljenosti temeljijo na ekstrapolaciji iz podatkov, ugotovljenih po uporabi fosamprenavirja 300 mg dvakrat na dan z ritonavirjem 100 mg enkrat na dan pri preiskovancih z zmerno okvaro jeter.
English: Tenofovir disoproxil 245 mg once daily
Slovenian: dizoproksiltenofovirat 245 mg enkrat dnevno
English: Loose stools, nausea, vomiting, abdominal pain
Slovenian: Bolezni prebavil driska zelo pogosti neredna stolica, navzea, bruhanje, abdominalne bolečine pogosti