FrancophonIA/ELRC3.0 huggingface dataset:
English: The liver has no significant role in the clearance of ibandronic acid, which is not metabolised but is cleared by renal excretion and by uptake into bone.
Slovenian: Jetra niso pomembna za očistek ibandronske kisline, ker se ne presnavlja, ampak izloča z renalno ekskrecijo in vstopanjem v kostno tkivo.
English: White to off white film-coated tablets, of oblong shape marked “BNVA” on one side, and “150” on the other side.
Slovenian: Filmsko obložene tablete so bele do sivo bele barve, podolgovate oblike z oznako “BNVA” na eni strani in “150” na drugi strani.
English: All patients must receive adequate supplemental calcium and vitamin D.
Slovenian: Vsi bolniki morajo prejemati ustrezne dodatke kalcija in vitamina D.
English: Other things that can increase the risk of fractures include: - not enough calcium and vitamin D in the diet - smoking, or drinking too much alcohol - not enough walking or other weight-bearing exercise - a family history of osteoporosis
Slovenian: Drugi dejavniki, ki lahko povečajo tveganje za zlome, so: - premajhen vnos kalcija in vitamina D s hrano, - kajenje ali čezmerno pitje alkohola, - pomanjkanje hoje ali drugih telesnih aktivnosti, - družinska obremenjenost z osteoporozo.
English: Some people need to be especially careful while they're taking Bondenza.
Slovenian: Nekateri ljudje morajo biti pri jemanju zdravila Bondenza še posebno previdni.
English: Bioavailability is reduced by about 90 % when ibandronic acid is administered with a standard breakfast in comparison with bioavailability seen in fasted subjects.
Slovenian: Pri sočasnem jemanju ibandronske kisline s standardnim zajtrkom se biološka uporabnost zmanjša za okoli 90 % v primerjavi z biološko uporabnostjo, ki so jo opazili pri bolnikih po postu.
English: PEEL-OFF STICKERS FOR YOUR PERSONAL CALENDAR Monthly tablet
Slovenian: NALEPKE ZA VAŠ OSEBNI KOLEDAR Mesečna tableta Mesečna tableta Mesečna tableta Bondenza
English: Bondenza 3 mg intravenous injection, administered every 3 months, was shown to be at least as effective as oral ibandronic acid 2.5 mg daily in a 2-year, randomised, double-blind, multicentre, noninferiority study (BM16550) of postmenopausal women (1386 women aged 55 - 80) with osteoporosis (lumbar spine BMD T-score below -2.5 SD at baseline).
Slovenian: Zdravilo Bondenza v obliki 3-mg intravenske injekcije, ki se daje vsake 3 mesece, se je izkazalo za najmanj enako učinkovito kakor ibandronska kislina 2,5 mg enkrat na dan peroralno v dveletni randomizirani, dvojno slepi, multicentrični, neinferiorni študiji (BM 16550) pri ženskah z osteoporozo v postmenopavzi (1.386 žensk, starih 55 do 80 let z izhodiščno T-vrednostjo MKG ledvene hrbtenice pod -2,5 SD).
English: 1 pre-filled syringe + 1 injection needle 4 pre-filled syringes + 4 injection needles
Slovenian: 1 napolnjena injekcijska brizga + 1 injekcijska igla 4 napolnjene injekcijske brizge + 4 injekcijske igle
English: - not enough calcium and vitamin D in the diet - smoking cigarettes, or drinking too much alcohol - not enough walking or other weight-bearing exercise - a family history of osteoporosis
Slovenian: - premajhen vnos kalcija in vitamina D s hrano, - kajenje cigaret ali čezmerno pitje alkohola, - pomanjkanje hoje ali drugih telesnih aktivnosti, - družinska obremenjenost z osteoporozo.
English: Ibandronic acid leads to progressive net gains in bone mass and a decreased incidence of fractures through the reduction of elevated bone turnover towards premenopausal levels in postmenopausal women.
Slovenian: Ibandronska kislina povzroči progresivno čisto povečanje kostne mase in zmanjša incidenco zlomov, tako da pri ženskah v postmenopavzi zmanjša povečano razmerje med razgradnjo in tvorbo kosti in ga približa razmerju pred menopavzo.
English: After one year (primary analysis) the median relative change from baseline was -76 % for Bondenza 150 mg once monthly and -67 % for ibandronic acid 2.5 mg daily.
Slovenian: Po enem letu (primarna analiza) je bila mediana relativne spremembe od izhodiščne vrednosti -76 % za zdravilo Bondenza 150 mg enkrat na mesec in -67 % za ibandronsko kislino 2,5 mg enkrat na dan.
English: Osteonecrosis of jaw*†
Slovenian: osteonekroza čeljustnic*†
English: - If you have certain problems with your gullet/food pipe (oesophagus) such as narrowing or difficulty swallowing.
Slovenian: - Če imate določene težave s požiralnikom, kot je zožitev ali težave s požiranjem.
English: How to receive Bondenza
Slovenian: Kako prejemati zdravilo Bondenza
English: There are no data on the effects of ibandronic acid from humans.
Slovenian: O vplivu ibandronske kisline pri ljudeh ni podatkov.
English: Bondenza 150 mg film-coated tablets Ibandronic acid
Slovenian: Bondenza 150 mg filmsko obložene tablete ibandronska kislina
English: Based on the results of study BM 16549, Bondenza 150 mg once monthly is expected to be at least as effective in preventing fractures as ibandronic acid 2.5 mg daily.
Slovenian: Glede na rezultate študije BM 16549 pričakujemo, da je zdravilo Bondenza 150 mg enkrat na mesec najmanj enako učinkovito v preprečevanju zlomov kakor ibandronska kislina 2,5 mg enkrat na dan.
English: Planning when to take Bondenza with peel-off stickers for your personal calendar What Bondenza is and what it is used for What you need to know before you take Bondenza How to take Bondenza
Slovenian: Kaj vsebuje navodilo Načrtovanje jemanja zdravila Bondenza z nalepkami za vaš osebni koledar Kaj je zdravilo Bondenza in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Bondenza Kako jemati zdravilo Bondenza Možni neželeni učinki 5 Shranjevanje zdravila Bondenza Vsebina pakiranja in dodatne informacije
English: Bondenza is available in packs of 1 pre-filled syringe and 1 injection needle or 4 pre-filled syringes and 4 injection needles.
Slovenian: Bondenza je na voljo v pakiranju po 1 napolnjeno injekcijsko brizgo in 1 injekcijsko iglo ali po 4 napolnjene injekcijske brizge in 4 injekcijske igle.
English: ibandronic acid 2.5 mg administered daily, showed a statistically significant and medically relevant reduction in the incidence of new vertebral fractures.
Slovenian: Dajanje 2,5 mg ibandronske kisline na dan je povzročilo statistično značilno in klinično pomembno zmanjšanje incidence novih zlomov vretenc.
English: If the next scheduled dose is within 7 days, patients should wait until their next dose and then continue taking one tablet once a month as originally scheduled.
Slovenian: Če je do naslednjega načrtovanega odmerka manj kot 7 dni, naj bolnik počaka do tega odmerka in nadaljuje jemanje ene tablete enkrat na mesec po prvotnem načrtu.
English: Table 2: Mean relative change from baseline of lumbar spine, total hip, femoral neck and trochanter BMD after one year (primary analysis) and two years of treatment (Per-Protocol Population) in study BM 16549.
Slovenian: Preglednica 2: Povprečna relativna sprememba od izhodiščne vrednosti MKG ledvene hrbtenice, kolka, femoralnega vratu in trohantra po enem letu (primarna analiza) in dveh letih zdravljenja (populacija po protokolu) v študiji BM 16549.
English: The absorption of ibandronic acid in the upper gastrointestinal tract is rapid after oral administration and plasma concentrations increase in a dose-proportional manner up to 50 mg oral intake, with greater than dose-proportional increases seen above this dose.
Slovenian: Po peroralnem jemanju je absorpcija ibandronske kisline v zgornjem delu gastrontestinalnega trakta hitra, plazemske koncentracije naraščajo do peroralnega vnosa 50 mg v odvisnosti od odmerka, pri večjih vnosih pa so opazili večje poraste plazemskih koncentracij od sorazmernih z odmerkom.
English: Due to the limited clinical experience, Bondenza is not recommended in patients with severe renal impairment (see section 4.2 and section 4.4) .
Slovenian: Zaradi omejenih kliničnih izkušenj jemanje zdravila Bondenza pri bolnikih s hudo okvaro ledvic ni priporočljivo (glejte poglavje 4.2 in poglavje 4.4).
English: Bondenza 3 mg injection every 3 months (N=365)
Slovenian: Bondenza 3 mg v obliki injekcije vsake 3 mesece (n = 365)
English: If you are breast-feeding, you will need to stop breast-feeding in order to receive Bondenza.
Slovenian: Če dojite, boste morali z dojenjem prenehati, da bi lahko prejemali zdravilo Bondenza.
English: The study enrolled women aged 55 to 80 years, who were at least 5 years postmenopausal, who had a BMD at lumbar spine of 2 to 5 SD below the premenopausal mean (T-score) in at least one vertebra [L1-L4], and who had one to four prevalent vertebral fractures.
Slovenian: Študija je vključevala ženske, stare od 55 do 80 let, ki so bile vsaj 5 let v postmenopavzi in ki so imele MKG ledvene hrbtenice 2 do 5 SD pod povprečno vrednostjo pred menopavzo (T-vrednost) pri vsaj enem vretencu (L1-L4) ter so imele enega do štiri predhodnih zlomov vretenc.
English: Existing hypocalcaemia must be corrected before starting Bondenza injection therapy.
Slovenian: Obstoječo hipokalcemijo je treba popraviti pred začetkom zdravljenja z zdravilom Bondenza v obliki injekcije.
English: Trochanter BMD
Slovenian: MKG trohantra
English: Appropriate medical support and monitoring measures should be readily available when Bondenza intravenous injection is administered.
Slovenian: Pri dajanju intravenske injekcije zdravila Bondenza mora biti na voljo ustrezna medicinska podpora in nadzor.
English: Bondenza 3 mg solution for injection in pre-filled syringes is a solution for intravenous injection by a health care professional.
Slovenian: Bondenza 3 mg raztopina za injiciranje v napolnjeni injekcijski brizgi je raztopina za intravensko injiciranje, ki jo daje zdravstveno osebje.
English: Physicians should be alert to any signs or symptoms signalling a possible oesophageal reaction and patients should be instructed to discontinue Bondenza and seek medical attention if they develop dysphagia, odynophagia, retrosternal pain or new or worsening heartburn.
Slovenian: Zdravniki morajo biti pozorni na znake ali simptome, ki opozarjajo na možno reakcijo v požiralniku, bolnikom pa je treba naročiti, da naj v primeru če se pri njih pojavijo disfagija, odinofagija,
English: However, since this increase is within the normal variability of the bioavailability of ibandronic acid, no dose adjustment is considered necessary when Bondenza is administered with H2antagonists or other active substances which increase gastric pH.
Slovenian: Ker je to zvečanje v mejah normalne variabilnosti biološke uporabnosti ibandronske kisline, pri sočasnem jemanju zdravila Bondenza z antagonisti histaminskih receptorjev H2 ali drugimi zdravili, ki zvečajo pH želodca, prilagajanje odmerkov ni potrebno.
English: EU/1/03/266/004
Slovenian: EU/1/03/266/003 EU/1/03/266/004
English: Bondenza 3 mg injection every 3 months (N=334)
Slovenian: Bondenza 3 mg v obliki injekcije vsake 3 mesece (n = 334)
English: Incidence of new morphometric vertebral fractures Relative risk reduction of clinical vertebral fracture Incidence of clinical vertebral fracture
Slovenian: Incidenca novih zlomov vretenc (določeno morfometrično) Zmanjšanje relativnega tveganja za klinične zlome vretenc Incidenca kliničnih zlomov vretenc
English: Of over 1500 patients enrolled in study BM 16549 comparing monthly with daily dosing regimens of ibandronic acid, 14 % and 18 % of patients used histamine (H2) blockers or proton pump inhibitors after one and two years, respectively.
Slovenian: Antagonisti histaminskih receptorjev H2 in zaviralci protonske črpalke Od več kot 1.500 bolnikov, vključenih v študijo BM 16549, ki je primerjala mesečno jemanje ibandronske kisline z dnevnim, je po enem letu 14 % bolnikov uporabljalo antagoniste histaminskih receptorjev H2 ali zaviralce protonske črpalke, po dveh letih pa 18 % bolnikov.
English: Bondenza 3 mg solution for injection ibandronic acid
Slovenian: Bondenza 3 mg raztopina za injiciranje ibandronska kislina
English: If a dose of Bondenza is missed
Slovenian: Če ste pozabili odmerek zdravila Bondenza
English: What Bondenza contains
Slovenian: Kaj vsebuje navodilo
English: Where Bondenza is administered via an existing intravenous infusion line, the intravenous infusate should be restricted to either isotonic saline or 50 mg/ml (5 %) glucose solution.
Slovenian: Kjer zdravilo Bondenza dajemo skozi obstoječi intravenski infuzijski kanal, je intravenski infuzat lahko le izotonična raztopina natrijevega klorida ali 50 mg/ml (5-%) raztopina glukoze.
English: Bondenza 3 mg injection every 3 months
Slovenian: Bondenza 3 mg v obliki injekcije, dane vsake 3 mesece
English: The overall proportion of patients who experienced an adverse reaction was 26.0 % and 28.6 % for Bondenza 3 mg injection every 3 months after one year and two years, respectively.
Slovenian: Celoten delež bolnikov, ki so imeli neželeni učinek, je bil 26,0 % za zdravilo Bondenza 3 mg v obliki injekcije, dane vsake 3 mesece, po enem letu in 28,6 % po dveh letih.
English: Bondenza is essentially sodium free.
Slovenian: Zdravilo Bondenza je praktično brez natrija.
English: If you're breast feeding, you may need to stop in order to take Bondenza.
Slovenian: Če dojite, boste morda morali z dojenjem prenehati, da bi lahko jemali zdravilo Bondenza.
English: In humans, the efficacy of both daily and intermittent administration with a dose-free interval of 9 - 10 weeks of ibandronic acid was confirmed in a clinical trial (MF 4411), in which ibandronic acid demonstrated anti-fracture efficacy.
Slovenian: Pri ljudeh je bila učinkovitost tako dnevnega kot intermitentnega dajanja ibandronske kisline z 9- do 10-tedenskim premorom brez odmerka potrjena v kliničnem preskušanju (MF 4411), v katerem je ibandronska kislina dokazala učinkovitost proti zlomom.
English: Furthermore, Bondenza 150 mg once monthly was proven superior to ibandronic acid 2.5 mg daily for increases in lumbar spine BMD in a prospectively planned analysis at one year, p=0.002, and at two years, p<0.001.
Slovenian: Zdravilo Bondenza 150 mg enkrat na mesec se je izkazalo za boljše kakor ibandronska kislina 2,5 mg enkrat na dan v povišanju MKG ledvene hrbtenice v prospektivno načrtovani analizi po enem letu, p = 0,002, in dveh letih, p < 0,001.
English: Calcium supplements, antacids and some oral medicinal products containing multivalent cations Calcium supplements, antacids and some oral medicinal products containing multivalent cations (such as aluminium, magnesium, iron) are likely to interfere with the absorption of Bondenza.
Slovenian: Dodatki kalcija, antacidi in nekatera peroralna zdravila, ki vsebujejo večvalentne katione Dodatki kalcija, antacidi in nekatera peroralna zdravila, ki vsebujejo večvalentne katione (kot so aluminij, magnezij, železo), lahko vplivajo na absorpcijo zdravila Bondenza, zato bolniki najmanj 6 ur pred zaužitjem zdravila Bondenza ter še 1 uro po ne smejo jemati drugih peroralnih zdravil.
English: Do not use this medicine after the expiry date which is stated on the carton and on the syringe after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli poleg oznake Uporabno do in na brizgi poleg oznake EXP. Datum izteka roka uporabnosti se nanaša na zadnji dan navedenega meseca.
English: Bondenza 150 mg once monthly was shown to be at least as effective as ibandronic acid 2.5 mg daily at increasing BMD in a two year, double-blind, multicentre study (BM 16549) of postmenopausal women with osteoporosis (lumbar spine BMD T score below -2.5 SD at baseline).
Slovenian: Zdravilo Bondenza 150 mg enkrat na mesec se je v povišanju MKG izkazalo za najmanj enako učinkovito kakor ibandronska kislina 2,5 mg enkrat na dan v dveletni dvojno slepi, multicentrični študiji (BM 16549) pri ženskah z osteoporozo v postmenopavzi (izhodiščna T-vrednost MKG ledvene hrbtenice pod -2,5 SD).
English: Bondenza 3 mg solution for injection in pre-filled syringe like other bisphosphonates administered intravenously, may cause a transient decrease in serum calcium values.
Slovenian: Bondenza 3 mg raztopina za injiciranje v napolnjeni injekcijski brizgi lahko kot drugi intravensko dajani difosfonati povzroči prehodno zmanjšanje koncentracije kalcija v serumu.
English: EU/1/03/266/006
Slovenian: EU/1/03/266/005 EU/1/03/266/006
English: Subjects with severe renal failure (CLcr less than 30 ml/min) receiving daily oral administration of 10 mg ibandronic acid for 21 days, had 2-3 fold higher plasma concentrations than subjects with normal renal function and total clearance of ibandronic acid was 44 ml/min.
Slovenian: Bolniki s hudo motnjo ledvičnega delovanja (CLcr manjši kot 30 ml/min), ki so prejemali peroralno 10 mg ibandronske kisline na dan 21 dni, so imeli 2- do 3-krat višje plazemske koncentracije kot osebe z normalno ledvično funkcijo.
English: In a two-year study in postmenopausal women with osteoporosis (BM 16549) the overall safety of Bondenza 150 mg once monthly and ibandronic acid 2.5 mg daily was similar.
Slovenian: V dveletni študiji pri ženskah z osteoporozo v postmenopavzi (BM 16549) je bila celokupna varnost zdravila Bondenza 150 mg enkrat na mesec in ibandronske kisline 2,5 mg enkrat na dan podobna.
English: PHARMACEUTICAL FORM AND CONTENTS Film-coated tablets
Slovenian: FARMACEVTSKA OBLIKA filmsko obložena tableta
English: Acetylsalicylic acid and NSAIDs In a two-year study in postmenopausal women with osteoporosis (BM 16549), the incidence of upper gastrointestinal events in patients concomitantly taking acetylsalicylic acid or NSAIDs was similar in patients taking ibandronic acid 2.5 mg daily or 150 mg once monthly after one and two years.
Slovenian: Acetilsalicilna kislina in nesteroidna protivnetna zdravila V dveletni študiji pri ženskah z osteoporozo v postmenopavzi (BM 16549), ki so sočasno jemale acetilsalicilno kislino ali nesteroidna protivnetna zdravila, je bila incidenca neželenih učinkov v zgornjem delu prebavil podobna pri tistih, ki so jemale ibandronsko kislino 2,5 mg vsak dan ali 150 mg enkrat na mesec eno ali dve leti.
English: Also contains sodium chloride, glacial acetic acid, sodium acetate trihydrate, water for injections.
Slovenian: Zdravilo vsebuje tudi natrijev klorid, koncentrirano ocetno kislino (ledocet), natrijev acetat trihidrat in vodo za injekcije.
English: Talk to your doctor before taking Bondenza: - If you have any disturbances of mineral metabolism (such as vitamin D deficiency).
Slovenian: Pred začetkom jemanja zdravila Bondenza se posvetujte s svojim zdravnikom: - če imate kakršnekoli motnje presnove mineralov (kot je pomanjkanje vitamina D), - če vaše ledvice ne delujejo normalno, - če imate težave s požiranjem ali prebavo.
English: Daily treatment with 2.5 mg resulted in progressive increases in BMD at vertebral and nonvertebral sites of the skeleton.
Slovenian: Zdravljenje z 2,5 mg na dan je povzročilo progresivno zvečanje MKG vretenc in nevretenčnih delov skeleta.
English: This includes: - eating a balanced diet rich in calcium and vitamin D - walking or other weight-bearing exercise - not smoking and not drinking too much alcohol
Slovenian: To vključuje - uravnoteženo prehrano, bogato s kalcijem in vitaminom D, - hojo ali druge telesne aktivnosti z vplivom na telesno maso, - opustitev kajenja in zmerno pitje alkohola.
English: NAME OF THE MEDICINAL PRODUCT Bondenza 3 mg solution for injection
Slovenian: IME ZDRAVILA Bondenza 3 mg raztopina za injiciranje
English: Due to limited clinical experience, Bondenza is not recommended for patients with a creatinine clearance below 30 ml/min (see section 5.2).
Slovenian: Zaradi malo kliničnih izkušenj zdravila Bondenza ne priporočamo bolnikom, ki imajo kreatininski očistek manjši kot 30 ml/min (glejte poglavje 5.2).
English: Bondenza may reverse bone loss by stopping more loss of bone and increasing bone mass in most women who take it, even though they won't be able to see or feel a difference.
Slovenian: S tem kostno maso poveča pri večini bolnic, ki ga jemljejo, čeprav same ne bodo videle ali čutile razlike.
English: However, based on a knowledge of this class of compounds, oral overdose may result in upper gastrointestinal adverse reactions (such as upset stomach, dyspepsia, oesophagitis, gastritis, or ulcer) or hypocalcaemia.
Slovenian: Glede na podatke o tej skupini zdravil lahko preveliko peroralno odmerjanje povzroči neželene učinke v zgornjem delu prebavil (kot so razdražen želodec, dispepsija, ezofagitis, gastritis ali razjeda) ali hipokalcemijo.
English: Due to limited clinical experience, Bondenza injection is not recommended for patients with a serum creatinine above 200 μmol/l (2.3 mg/dl) or with a creatinine clearance below 30 ml/min (see section 4.2 and section 5.2).
Slovenian: Zaradi omejenih kliničnih izkušenj zdravila Bondenza v obliki injekcije ne priporočamo bolnikom, ki imajo serumski kreatinin nad 200 µmol/l (2,3 mg/dl) ali kreatininski očistek, manjši kot 30 ml/min (glejte poglavje 4.2 in poglavje 5.2).
English: Cellulose, microcrystalline Crospovidone Stearic acid
Slovenian: Jedro tablete laktoza monohidrat povidon mikrokristalna celuloza krospovidon stearinska kislina brezvoden koloidni silicijev dioksid
English: What Bondenza contains - The active substance is ibandronic acid.
Slovenian: Kaj vsebuje zdravilo Bondenza - Zdravilna učinkovina je ibandronska kislina.
English: Bondenza 3 mg solution for injection in pre-filled syringes is a clear colourless solution.
Slovenian: Bondenza 3 mg raztopina za injiciranje v napolnjeni injekcijski brizgi je bistra, brezbarvna raztopina.
English: Bondenza injection is not recommended for use in patients who have a serum creatinine above 200 μmol/l (2.3 mg/dl) or who have a creatinine clearance (measured or estimated) below 30 ml/min, because of limited clinical data available from studies including such patients (see section 4.4 and section 5.2).
Slovenian: Uporaba zdravila Bondenza v obliki injekcije pri bolnikih s serumskim kreatininom nad 200 µmol/l (2,3 mg/dl) ali s kreatininskim očistkom (izmerjenim ali ocenjenim) pod 30 ml/min zaradi malo kliničnih podatkov iz študij, ki so vključevale take bolnike, ni priporočljiva (glejte poglavji 4.4 in 5.2).
English: Therefore, patients should fast overnight (at least 6 hours) before taking Bondenza and continue fasting for 1 hour following intake of Bondenza (see section 4.2).
Slovenian: Zato morajo bolniki jemati zdravilo Bondenza zjutraj na prazen želodec (vsaj 6 ur brez obroka), po zaužitju zdravila Bondenza pa morajo biti še 1 uro tešči (glejte poglavje
English: • new pain, weakness or discomfort in your thigh, hip or groin.
Slovenian: • na novo nastala bolečina, šibkost ali neugodje v stegnih, kolku ali dimljah.
English: • Place all used needles and syringes into a sharps container (puncture-proof disposable container).
Slovenian: • uporabljenje igle in injekcijske brizge odvrzite v zabojnik za ostre predmete;
English: The treatment effect of ibandronic acid was further assessed in an analysis of the subpopulation of patients who at baseline had a lumbar spine BMD T-score below -2.5.
Slovenian: Učinek zdravljenja z ibandronsko kislino so nadalje proučevali v analizi podskupine bolnikov, katerih T-vrednost MKG ledvene hrbtenice je bila na začetku zdravljenja pod -2,5.
English: - Patients should not lie down for 1 hour after taking Bondenza.
Slovenian: - Po zaužitju zdravila Bondenza bolniki 1 uro ne smejo leči.
English: - Take your Bondenza tablet after you first get up for the day, and before you have anything to eat or drink (on an empty stomach) - Swallow your tablet with a full glass of water (at least 180 ml).
Slovenian: - Vzemite tableto zdravila Bondenza ko zjutraj vstanete in preden karkoli pojeste ali popijete (na prazen želodec).
English: • heartburn, discomfort in swallowing, stomach or tummy pain (may be due to an inflammation of the stomach), indigestion, nausea, having diarrhoea (loose bowels)
Slovenian: • zgaga, neugodje pri požiranju, bolečina v želodcu ali trebuhu (lahko zaradi vnetja želodca),