FrancophonIA/ELRC3.0 huggingface dataset:
English: In clinical studies and the post-marketing setting pulmonary adverse effects including interstitial lung disease, pulmonary oedema, and lung infiltration have been reported in some cases with an outcome of respiratory failure or acute respiratory distress syndrome (ARDS), which may be fatal (see section
Danish: Der er i kliniske studier og efter markedsføringen rapporteret om pulmonale bivirkninger, herunder interstitiel lungesygdom, lungeødem og lungeinfiltrationer.
English: The mechanism of vasculitis in patients receiving filgrastim is unknown.
Danish: Der er rapporteret om kutan vaskulitis hos patienter, der er behandlet med filgrastim, Den underliggende mekanisme i forbindelse med kutan vaskulitis hos patienter, der er behandlet med filgrastim er ukendt.
English: Solution for injection/infusion (injection/infusion).
Danish: Injektions-/infusionsvæske, opløsning.
English: • coughing up blood (haemoptysis)
Danish: • Ophostning af blod (hæmoptyse)
English: Nivestim 48 MU/0.5 ml injection/infusion filgrastim
Danish: Nivestim 48 ME/0,5 ml injektion/infusion filgrastim s.c./i.v.
English: Nivestim 12 MU/0.2 ml solution for injection/infusion Nivestim 30 MU/0.5 ml solution for injection/infusion Nivestim 48 MU/0.5 ml solution for injection/infusion filgrastim
Danish: Nivestim 12 ME/0,2 ml injektions-/infusionsvæske, opløsning Nivestim 30 ME/0,5 ml injektions-/infusionsvæske, opløsning Nivestim 48 ME/0,5 ml injektions-/infusionsvæske, opløsning filgrastim
English: Nivestim 12 MU/0.2 ml injection/infusion filgrastim
Danish: Nivestim 12 ME/0,2 ml injektion/infusion filgrastim s.c./i.v.
English: White blood cell counts of 100 x 10
Danish: Der er påvist leukocyttal på 100 x 10
English: If your nurse or doctor recommends it, clean the area of skin with an antiseptic wipe.
Danish: Du skal rense stedet med en antiseptisk spritserviet, hvis lægen eller sygeplejersken har anbefalet det,
English: In patients undergoing a stem cell or bone marrow transplant, Graft versus host disease (GvHD) may occur - this is a reaction of the donor cells against the patient receiving the transplant; signs and symptoms include rash on the palms of your hands or soles of your feet and ulcer and sores in your mouth, gut, liver, skin, or your eyes, lungs, vagina and joints.
Danish: Tegn og symptomer omfatter udslæt i håndfladerne eller under fødderne og sår i munden, tarmene, leveren, huden eller i øjne, lunger, skede og led.
English: • pain
Danish: • Smerter
English: In view of limited safety and efficacy data in patients with secondary AML, filgrastim should be administered with caution.
Danish: Filgrastim bør gives med forsigtighed til patienter med sekundær AML, da der foreligger begrænsede data om sikkerhed og effekt hos disse patienter.
English: Each pre-filled syringe contains 12 million units (MU) (120 micrograms [µg]) of filgrastim in 0.2 ml (0.6 mg/ml).
Danish: Hver fyldt sprøjte indeholder 12 mio enheder (ME) (120 mikrogram [µg]) filgrastim i 0,2 ml (0,6 mg/ml).
English: The use of filgrastim-mobilised PBPCs has been shown to reduce the depth and duration of thrombocytopenia following myelosuppressive or myeloablative chemotherapy.
Danish: Det har vist sig, at sværhedsgraden og varigheden af trombocytopeni efter myelosuppressiv eller myeloablativ kemoterapi nedsættes ved brug af PBPC, som er mobiliseret af filgrastim.
English: In view of the sensitivity of rapidly dividing myeloid cells to myelosuppressive cytotoxic chemotherapy, the use of filgrastim is not recommended in the period from 24 hours before to 24 hours after chemotherapy.
Danish: Filgrastim bør ikke anvendes i perioden 24 timer før til 24 timer efter kemoterapi på grund af de hurtigt delende myeloide cellers følsomhed over for myelosuppressiv cytotoksisk kemoterapi.
English: Rash maculopapular
Danish: Maculo-papuløst udslæt
English: Each pre-filled syringe contains 30 million units (MU) (300 micrograms [µg]) of filgrastim in 0.5 ml (0.6 mg/ml).
Danish: Hver fyldt sprøjte indeholder 30 mio enheder (ME) (300 mikrogram [µg]) filgrastim i 0,5 ml (0,6 mg/ml).
English: Each pre-filled syringe contains 12 million units (MU) (120 g) of filgrastim in 0.2 ml (0.6 mg/ml)
Danish: Hver fyldt sprøjte indeholder 12 mio enheder (ME) (120 µg) filgrastim i 0,2 ml (0,6 mg/ml)
English: 35% of donors (see section 4.4).
Danish: 9/l) hos 35 % af donorerne.
English: Each pre-filled syringe contains 30 million units (MU) (300 g) of filgrastim in 0.5 ml (0.6 mg/ml)
Danish: Hver fyldt sprøjte indeholder 30 mio enheder (ME) (300 µg) filgrastim i 0,5 ml (0,6 mg/ml)
English: Common side effects (may affect up to 1 in 10 people):
Danish: Almindelige bivirkninger (kan forekomme hos op til 1 ud af 10 personer)
English: Uncommon side effects (may affect up to 1 in 100 people):
Danish: Ualmindelige bivirkninger (kan forekomme hos mellem 1 og 100):
English: • cough
Danish: • Hoste
English: Nivestim 30 MU/0.5 ml injection/infusion filgrastim
Danish: Nivestim 30 ME/0,5 ml injektion/infusion filgrastim s.c./i.v.
English: • vomiting
Danish: • Opkastning
English: 9/L) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate.
Danish: Filgrastim er indiceret til behandling af persisterende neutropeni (ANC mindre end eller lig med 1,0 x 109/l) hos patienter med fremskreden HIV-infektion for at nedsætte risikoen for bakterielle infektioner, hvis der ikke er andre egnede behandlinger.
English: TRM
Danish: Kvalme
English: Transient thrombocytopenia (platelets < 100 x 10
Danish: (trombocyttal < 100 x 10
English: Nivestim 30 MU/0.5 ml solution for injection/infusion, Nivestim 48 MU/0.5 ml solution for injection/infusion
Danish: Nivestim 30 ME/0,5 ml injektions-/infusionsvæske, opløsning, Nivestim 48 ME/ 0,5 ml injektions/infusionsvæske, opløsning
English: - If you have any further questions, ask your doctor, nurse or pharmacist.
Danish: Er du i tvivl, så spørg lægen, sundhedspersonalet eller apotekspersonalet.
English: OUTER CARTON
Danish: YDRE PAKNING
English: Musculoskeletal pain c
Danish: Muskelspasmer Osteoporose
English: Because of the potential of receiving higher doses of chemotherapy (e.g. full doses on the prescribed schedule) the patient may be at greater risk of thrombocytopenia and anaemia.
Danish: Patienterne kan have større risiko for at udvikle trombocytopeni og anæmi på grund af muligheden for at få højere kemoterapidoser (f.eks. de højeste doser i det foreskrevne doseringsskema).
English: Among these, two cases of platelets < 50 x 10
Danish: Blandt disse blev der rapporteret om to tilfælde af trombocyttal
English: Further dose adjustment may be necessary, as determined by the patient's ANC, to maintain the neutrophil count at > 2.0 x 10
Danish: 9/l kan det blive nødvendigt med flere dosisjusteringer, afhængig af patienternes ANC.
English: • bumpy skin rash (rash maculo-papular)
Danish: • Ujævnt hududslæt (maculo-papuløst udslæt)
English: Oedema peripheral e
Danish: Utilpashed Perifert ødem
English: Haemoptysis Dyspnoea Cough a
Danish: Hæmoptyse Dyspnø Hoste
English: Pulmonary haemorrhage Interstitial lung disease a
Danish: Acute Respiratory Distress Syndrome Respirationssvigt Lungeødem Pulmonal hæmoragi Interstitiel lungesygdom Lungeinfiltration Hypoksi
English: Nivestim 12 MU/0.2 ml solution for injection/infusion
Danish: Nivestim 12 ME/0,2 ml injektions-/infusionsvæske, opløsning
English: Erythema
Danish: Udslæt Erytem
English: Equipment required for administration
Danish: Nødvendigt udstyr til indsprøjtningen
English: > 1.0 x 10 9/L for 3 consecutive days
Danish: 9/l i 3 konsekutive dage
English: • oral pain
Danish: • Muskelspasmer
English: 9/L were reported and attributed to the leukapheresis procedure.
Danish: 9/l før leukaferesen.
English: Graft versus Host Disease b
Danish: Overfølsomhed Lægemiddeloverfølsomhed Graft versus værtsygdom
English: • chest pain
Danish: • Brystsmerter
English: Bioavailability was shown to be high.
Danish: Biotilgængeligheden blev påvist at være høj.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 19/09/2013
Danish: DATO FOR FØRSTE TILLADELSE/FORNYELSE AF TILLADELSEN Dato for første markedsføringstilladelse: 19/09/2013
English: Each tablet contains:
Danish: Hver tablet indeholder:
English: There is no antidote available.
Danish: Der findes ingen modgift.
English: Accurate dosing is not possible in dogs weighing less than 3.9 kg.
Danish: Nøjagtig dosering er ikke muligt hos hunde, som vejer under 3,9 kg.
English: All dogs within the household should be treated.
Danish: Alle hunde i husstanden skal behandles.
English: Then start a new monthly dosing schedule from that day.
Danish: Start derefter en ny månedlig doseringsplan fra den dag.
English: Do not use in dogs under 14 weeks of age.
Danish: Bør ikke anvendes til hunde yngre end 14 uger.
English: Children must not come into contact with the veterinary medicinal product.
Danish: Børn må ikke komme i kontakt med veterinærlægemidlet.
English: UNITED KINGDOM
Danish: STORBRITANNIEN
English: Do not use this veterinary medicinal product after the expiry date which is stated on the blister after EXP.
Danish: Brug ikke dette veterinærlægemiddel efter den udløbsdato, der står på blisterpakken efter EXP.
English: The recommended dosage regimen must be followed but not exceeded.
Danish: Det anbefalede doseringsregimen bør følges, men ikke overstiges.
English: ATCvet code: QP54AB51 (milbemycin combinations).
Danish: ATCvet-kode: QP54AB51 (milbemycin-kombinationer).
English: Unlike spinosad, the consistent ratio of the individual factors is not maintained in pharmacokinetic studies.
Danish: I modsætning til for spinosad vedholdes det konsekvente forhold mellem de enkelte faktorer ikke i farmakokinetiske undersøgelser.
English: If you notice any serious effects or other effects not mentioned in this package leaflet, please, inform your veterinary surgeon.
Danish: Hvis De bemærker alvorlige bivirkninger eller andre bivirkninger, som ikke er omtalt i denne indlægsseddel, bedes De kontakte Deres dyrlæge.
English: Trough concentrations of spinosad doubled monthly up to month 5.
Danish: Trugkoncentrationer af spinosad blev fordoblet hver måned op til 5. måned.
English: Plasma protein binding is high (>96%).
Danish: Plasmaproteinbinding er høj (> 96%).
English: Plasma protein binding is high (>98%).
Danish: Plasmaproteinbinding er høj (> 98%).
English: The consistency of this figure in pharmacokinetic and other studies indicates comparability in the absorption, metabolism and elimination of the two major spinosyns.
Danish: Konsekvensen af dette tal i farmakokinetiske og andre studier angiver sammenlignelighed i absorption, metabolisme og eliminering af de to vigtigste spinosyner.
English: A single treatment is effective for the treatment of gastrointestinal nematodes.
Danish: En enkelt behandling er effektiv til behandling af gastrointestinale nematoder.
English: The blister packs are formed from aluminium laminates, heat sealed with a PVC based coating (the product contact surface is PVC).
Danish: Blisterpakkerne er dannet af aluminiumslaminater, varmeforseglet med en PVC-baseret belægning (produktets kontaktflade er PVC).
English: Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species in order to limit the possibility of a future selection for resistance.
Danish: Brugen af dette produkt skal derfor ske ud fra en vurdering af det enkelte tilfælde og på grundlag af lokale epidemiske oplysninger om den aktuelle følsomhed for den dyreart, som er målet, for at begrænse muligheden for selektionen af resistens i fremtiden.
English: Therefore, concomitant treatment with other P-gp substrates could lead to enhanced toxicity.
Danish: Samtidig behandling med andre P-gp-substrater kan derfor medføre øget toksicitet.
English: Carton containing 1 blister pack.
Danish: Kartonen indeholder 1 blisterpakke.
English: Seek veterinary advice regarding information on the optimal time to start treatment with this veterinary medicinal product.
Danish: Spørg dyrlægen om råd angående det optimale tidspunkt for start af behandling med veterinærlægemidlet.
English: These effects are caused primarily by activation of nicotinic acetylcholine receptors (nAChRs).
Danish: Disse virkninger er hovedsagligt forårsaget af aktivering af nikotin-kolinerge receptorer (nAChR'er).
English: THE WORDS “FOR ANIMAL TREATMENT ONLY” AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, if applicable
Danish: TEKSTEN ”KUN TIL DYR” SAMT BETINGELSER ELLER BEGRÆNSNINGER FOR UDLEVERING OG BRUG, OM NØDVENDIGT
English: Approximately 90% of spinosad is comprised of spinosyns A and D. Of that 90%, the ratio of spinosyn A to A+D is 0.85 when calculated as spinosyn A/spinosyn A+D.
Danish: Cirka 90% af spinosad består af spinosyner A og D. Af de 90%, er forholdet af spinosyn A til A+D 0,85 når beregnet som spinosyn A/spinosyn A+D.
English: WITHDRAWAL PERIOD Not applicable.
Danish: 10. TILBAGEHOLDELSESTID Ikke relevant.
English: In the majority of cases, vomiting was transient and mild and did not require symptomatic treatment.
Danish: I de fleste tilfælde var opkastningen forbigående og mild og krævede ikke symptomatisk behandling.
English: The veterinary medicinal product should be administered with food or immediately after feeding.
Danish: Veterinærlægemidlet skal indgives med foder eller umiddelbart efter fodring.
English: The duration of efficacy may be reduced if the dose is administered on an empty stomach.
Danish: Effektens varighed kan reduceres, hvis dosen indgives på tom mave.
English: The veterinary medicinal product must be administered 1 month before the expected appearance of mosquitoes.
Danish: Veterinærlægemidlet skal indgives inden for 1 måned inden den forventede forekomst af myg.
English: Further information for the prescribing veterinarian:
Danish: Yderligere oplysninger til den ordinerende dyrlæge:
English: Spinosad starts killing fleas 30 minutes after administration; 100% of fleas are dead/moribund within 4 hours post-treatment.
Danish: Spinosad begynder at dræbe lopper 30 minutter efter indgift; 100% af lopper er døde/døende inden for 4 timer efter behandling.
English: Body weight (kg) of dog
Danish: Hundens legemsvægt (kg)
English: At this time, the systemic exposure (AUC) in juveniles was comparable to adults.
Danish: På det tidspunkt var den systemiske eksponering (AUC) hos unge hunde svarende til som hos voksne.
English: Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency (http://www.ema.europa.eu/).
Danish: Yderligere information om dette lægemiddel er tilgængelig på Det Europæiske Lægemiddelagenturs hjemmeside (http://www.ema.europa.eu/).
English: This combination product (Trifexis) must, however, not be given for more than 6 consecutive months in any one year.
Danish: Dette kombinationsprodukt (Trifexis) bør dog ikke indgives i mere end 6 på hinanden følgende måneder i et givent år.
English: A commonly observed adverse reaction is vomiting, which occurs in the first 48 hours after dosing.
Danish: En almindeligt set bivirkning er opkastning, der sædvanligvis forekommer i de første 48 timer efter dosering.
English: Prior to treatment with Trifexis the advice in section 12 should be considered.
Danish: Inden behandling med Trifexis skal oplysningerne i afsnit 12 overvejes.
English: This leads to hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of the parasite.
Danish: Dette fører til hyperpolarisering af den neuromuskulære membran, hvilket medfører paralyse og død af parasitten.
English: Cats in the household should be treated with a veterinary medicinal product authorised for use in that species.
Danish: Katte i samme husstand skal behandles med et veterinærlægemiddel, der er godkendt til brug i den dyreart.
English: Parasite resistance to any particular class of anthelmintic may develop following the frequent, repeated use of an anthelmintic of that class.
Danish: Parasitten kan udvikle resistens mod en bestemt klasse ormemiddel efter hyppig, gentagen brug af et ormemiddel i den klasse.
English: The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Danish: Veterinærlægemidlet kan anvendes som del af en behandlingsstrategi til at kontrollere loppeallergidermatitis (FAD).
English: After treatment of the nematode infection, further flea prevention should be continued with a monovalent product.
Danish: Efter behandling af nematodeinfektionen bør yderligere loppeforebyggelse fortsættes med et enkeltstofpræparat.
English: Cartons containing a blister pack with 1, 3 or 6 chewable tablets.
Danish: Kartoner indeholdende en blisterpakke med 1, 3 eller 6 tyggetabletter.
English: In a separate study with three consecutive monthly administrations, no increases in Cmax, AUC, or elimination half-lives were noted when comparing values from the third and first months.
Danish: I et separat studie med indgift en gang om måneden i tre på hinanden følgende måneder blev der ikke set nogen stigninger i Cmax, AUC eller elimineringshalveringstider, når værdier fra den tredje og første måned blev sammenlignet.
English: It is active against mites, larval and adult stages of nematodes as well as larvae of Dirofilaria immitis.
Danish: Det er virksomt mod mider, larve- og voksenstadier af nematoder såvel som mod larver af Dirofilaria immitis.
English: Pharmacotherapeutic group: Antiparasitic products, insecticides and repellents - endectocides.
Danish: Farmakoterapeutisk gruppe: Antiparasitære midler, insekticider og repellenter - endektocider.
English: After spinosad administration, the incidence of vomiting on the day of, or the day after dosing has been observed to increase as a function of the dose.
Danish: Efter indgift af spinosad er der observeret en stigning i forekomsten af opkastning på samme dag eller dagen efter dosering som en funktion af dosis.
English: The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment) - common (more than 1 but less than 10 animals in 100 animals) - uncommon (more than 1 but less than 10 animals in 1,000 animals) - rare (more than 1 but less than 10 animals in 10,000 animals) - very rare (less than 1 animal in 10,000 animals, including isolated reports).
Danish: Hyppigheden af bivirkninger er defineret som: - Meget almindelig (mere end 1 ud af 10 dyr, der viser bivirkninger i løbet af en behandling) - Almindelige (mere end 1, men mindre end 10 dyr i 100 dyr) - Ualmindelige (mere end 1, men mindre end 10 dyr i 1.000 dyr) - Sjældne (mere end 1, men mindre end 10 dyr ud af 10.000 dyr) - Meget sjælden (mindre end 1 dyr ud af 10.000 dyr, herunder isolerede rapporter).
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Outer carton
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Ydre karton
English: The use of the veterinary medicinal product in such dogs is therefore not recommended.
Danish: Anvendelsen af veterinærlægemidlet til sådanne hunde frarådes derfor.
English: Milbemycin oxime is a systemic macrocyclic lactone containing two major factors, A3 and A4 (ratio of A3:A4 is 20:80).
Danish: Milbemycinoxim er et systemisk makrocyklisk lakton, der indeholder to hovedfaktorer A3 og A4 (forholdet A3:A4 er 20:80).
English: In case of a massive flea infestation, and at the beginning of the control measures, these areas should be treated with a suitable insecticide and then vacuumed regularly.
Danish: I tilfælde af en svær infestation samt ved starten af behandlingen skal disse områder derfor behandles med et egnet insekticid, og de bør støvsuges regelmæssigt.
English: When Trifexis is used to replace another heartworm preventive product, the first dose of Trifexis must be given within a month of the last dose of the former medication.
Danish: Når Trifexis erstatter et andet produkt til forebyggelse af hjerteorm, skal den første dosis af Trifexis indgives inden for en måned efter den sidste dosis af den tidligere medicin.
English: Milbemycin oxime is isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus.
Danish: Milbemycinoxim er isoleret fra fermenteringen af Streptomyces hygroscopicus var. aureolacrimosus.
English: Dogs travelling to a heartworm region should start medication within a month after arrival there.
Danish: Hunde, som skal rejse til et område med hjerteorm, skal begynde behandling med medicinen inden for en måned efter ankomst der.
English: The excretion of milbemycin oxime in lactating dogs (bitches) has not been tested and the safety for suckling puppies has not been established.
Danish: Udskillelsen af milbemycinoxim hos diegivende hunde (tæver) er ikke blevet testet, og sikkerheden hos diende hunde er ikke blevet fastlagt.
English: Vomiting is most likely caused by a local effect on the small intestine.
Danish: Opkastning skyldes sandsynligvis en lokal virkning på tyndtarmen.
English: Postmarketing reports for spinosad indicate that in very rare cases, blindness, impaired vision and other eye disorders were observed.
Danish: Rapporter for spinosad efter markedsføringen angiver, at der i meget sjældne tilfælde blev set blindhed, svækket syn og andre øjensygdomme.
English: The product can be administered as part of a seasonal prevention strategy when fleas and mosquitoes or snails/slugs are present.
Danish: Produktet kan gives som en del af et program til sæsonmæssig forebyggelse, når lopper og myg eller snegle er til stede.
English: If vomiting occurs within an hour of administration and the tablet is visible, re-dose with another full dose.
Danish: Hvis der forekommer opkastning inden for en time efter indgift, og tabletten kan ses, skal hunden gives en ny fuld dosis.
English: A slight increase in plasma liver enzymes and haemoglobin distribution width (HDW) was observed during the study but no clinically relevant signs was attributed to these changes.
Danish: En lille stigning i leverenzymer i blodet og hæmoglobindistributionsbredde (HDW) blev observeret i løbet af forsøget, men disse ændringer blev ikke tillagt nogen klinisk relevans.
English: Use with caution in dogs with pre-existing epilepsy.
Danish: Vær forsigtig ved anvendelse til hunde med præeksisterende epilepsi.
English: The veterinary medicinal product should be administered in accordance with the following table to ensure a dose of 45 to 70 mg spinosad and 0.75 to 1.18 mg milbemycin oxime/kg bodyweight.
Danish: Veterinærlægemidlet skal indgives i overensstemmelse med følgende tabel for at garantere en dosis på 45 - 70 mg/kg spinosad og 0,75 - 1,18 mg milbemycinoxim/kg legemsvægt.
English: Spinosad therefore has a different mode of action to other flea control or insect control products.
Danish: Spinosad har således en anden virkningsmekanisme end andre produkter til bekæmpelse af lopper eller insekter.
English: DATE ON WHICH THE PACKAGE LEAFLET WAS LAST APPROVED Detailed information on this product is available on the website of the European Medicines Agency (http://www.ema.europa.eu/).
Danish: DATO FOR SENESTE GODKENDELSE AF INDLÆGSSEDLEN Yderligere information om dette lægemiddel er tilgængelig på Det Europæiske Lægemiddelagenturs hjemmeside (http://www.ema.europa.eu/).
English: The following list shows the code and the number of dimples marked on each strength of tablet:
Danish: Følgende liste angiver koden og antallet af fordybninger indpræget på hver tabletstyrke:
English: If the dog does not accept the tablet(s) directly in its mouth then the tablet(s) may be mixed with food.
Danish: Hvis hunden ikke vil tage tabletten (tabletterne) direkte i munden, kan de(n) gives i foderet.
English: All adverse events were transient and did not require treatment.
Danish: Alle bivirkninger var forbigående og krævede ikke behandling.
English: Excretion is primarily via faeces, and also to a lesser extent in the urine.
Danish: Udskillelse sker hovedsagligt gennem galde og afføring og i mindre udstrækning i urinen.