FrancophonIA/ELRC3.0 huggingface dataset:
English: The population included 27.8% women, 58.4% patients ≥ 60 years (26% ≥ 70 years) and 54.5% patients who received fibrinolytics.
Croatian: bolesnika ≥60 godina (26% ≥70 godina) i 54,5% bolesnika koji su primali fibrinolitike.
English: After repeated doses of 75 mg clopidogrel per day in subjects with severe renal disease (creatinine clearance from 5 to 15 ml/min), inhibition of ADP-induced platelet aggregation was lower (25%) than that observed in healthy subjects however, the prolongation of bleeding time was similar to that seen in healthy subjects receiving 75 mg of clopidogrel per day.
Croatian: Nakon ponovljenih doza od 75 mg klopidogrela dnevno, inhibicija ADP-om inducirane agregacije trombocita bila je niža (25%) u ispitanika s teško narušenom funkcijom bubrega (klirens kreatinina od 5 do 15 ml/min), u usporedbi sa zdravim ispitanicima, iako je produljenje vremena krvarenja bilo slično onom zabilježenom u zdravih bolesnika koji su primali 75 mg klopidogrela dnevno.
English: - ST segment elevation acute myocardial infarction: clopidogrel should be given as a single daily dose of 75 mg initiated with a 300 mg loading dose in combination with ASA and with or without thrombolytics.
Croatian: - Akutni infarkt miokarda s elevacijom ST-segmenta: liječenje klopidogrelom provodi se jednom dnevnom dozom od 75 mg, a započinje udarnom dozom od 300 mg u kombinaciji s ASK te sa ili bez trombolitika.
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 2 or section
Croatian: - Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 2 ili dijelu 6.1.
English: • Paediatric population Clopidogrel should not be used in children because of efficacy concerns (see section 5.1).
Croatian: - Pedijatrijska populacija Klopidogrel se ne primjenjuje u djece zbog nedovoljnih podataka o djelotvornosti (vidjeti dio
English: An appropriate dose regimen for this patient population has not been established in clinical outcome trials.
Croatian: U kliničkim studijama nije utvrđen odgovarajući režim doziranja za ovu populaciju bolesnika.
English: Patients should be told that it might take longer than usual to stop bleeding when they take clopidogrel (alone or in combination with ASA), and that they should report any unusual bleeding (site or duration) to their physician.
Croatian: Bolesnicima koji uzimaju klopidogrel (kao monoterapiju ili u kombinaciji s ASK) potrebno je objasniti da će krvarenje možda trajati dulje nego obično i da moraju obavijestiti liječnika o bilo kakvom neočekivanom krvarenju (s obzirom na mjesto i trajanje krvarenja).
English: Intracranial bleeding (some cases were reported with fatal outcome), headache, paraesthesia, dizziness
Croatian: Poremećaji živčanog sustava intrakranijalno krvarenje (prijavljeni su neki slučajevi s fatalnim ishodom) glavobolja, parestezija, omaglica poremećaj okusa, ageuzija
English: If you have experienced severe chest pain (unstable angina or heart attack), your doctor may give you 300 mg of Clopidogrel Krka d.d.
Croatian: Ako ste imali jake bolove u prsištu (nestabilna angina ili srčani udar), liječnik Vam u početku liječenja može jednokratno dati 300 mg Clopidogrela Krka d.d. (4 tablete od po 75 mg).
English: The concomitant administration of clopidogrel with oral anticoagulants is not recommended since it may increase the intensity of bleedings (see section 4.5).
Croatian: Ne preporučuje se istodobna primjena klopidogrela i drugih oralnih antikoagulansa, jer to može pojačati intenzitet krvarenja (vidjeti dio 4.5).
English: No new safety concerns were noted during this long-term follow-up.
Croatian: Nisu primjećeni problemi vezani uz sigurnost primjene lijeka tijekom ove dugotrajne nastavne studije.
English: plus acetylsalicylic acid if you cannot take ‘oral anticoagulants' and you do not have a risk of major bleeding.
Croatian: Liječnik Vam treba propisati Clopidogrel Krka d.d. i acetilsalicilatnu kiselinu ako ne možete uzimati oralne antikoagulanse te nemate rizik od velikog krvarenja.
English: Common side effects (may affect up to 1 in 10 people): Diarrhoea, abdominal pain, indigestion or heartburn.
Croatian: Česte nuspojave (mogu se javiti u manje od 1 na 10 osoba): proljev, bol u trbuhu, probavne tegobe ili žgaravica.
English: Other concomitant therapy: Since clopidogrel is metabolised to its active metabolite partly by CYP2C19, use of medicinal products that inhibit the activity of this enzyme would be expected to result in reduced drug levels of the active metabolite of clopidogrel.
Croatian: Ostala istodobna terapija: s obzirom da se klopidogrel do svog aktivnog metabolita djelomično metabolizira enzimom CYP2C19, očekuje se da će primjena lijekova koji inhibiraju aktivnost ovog enzima rezultirati smanjenim razinama aktivnog metabolita klopidogrela.
English: This was consistent across subgroups of patients defined by baseline characteristics, and type of fibrinolytic or heparin therapy.
Croatian: Sukladni podaci dobiveni su i u podskupinama bolesnika definiranim prema početnim karakteristikama i tipu terapije fibrinoliticima ili heparinom.
English: to help prevent blood clots and reduce the risk of these severe events because: - You have a condition of hardening of arteries (also known as atherosclerosis), and - You have previously experienced a heart attack, stroke or have a condition known as peripheral arterial disease.
Croatian: Clopidogrel Krka d.d. Vam je propisan za sprječavanje stvaranja krvnih ugrušaka i smanjivanje opasnosti od ovih ozbiljnih događaja jer: - imate otvrdnuće arterija (koje se još zove ateroskleroza) te - ste već imali srčani udar, moždani udar ili imate stanje koje se zove bolest perifernih arterija, - ste imali teški oblik boli u prsištu, poznat pod nazivom “nestabilna angina” ili “infarkt miokarda” (srčani udar).
English: Bullous dermatitis (toxic epidermal necrolysis, Stevens Johnson Syndrome, erythema multiforme, acute generalised exanthematous pustulosis (AGEP)), angioedema, drug-induced hypersensitivity syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), rash erythematous or exfoliative, urticaria, eczema, lichen planus
Croatian: bulozni dermatitis (toksična epidermalna nekroliza, Stevens Johnsonov sindrom, erythema multiforme, akutna generalizirana egzantematozna pustuloza (AGEP)), angioedem, sindrom preosjetljivosti izazvan lijekom, osip uzrokovan lijekom s eozinofilijom i sistemskim simptomima (engl.
English: • If you suffer from severe liver disease.
Croatian: - Ako imate bolest bubrega ili jetre.
English: Patients were randomised to clopidogrel 75 mg/day or ASA 325 mg/day, and were followed for 1 to 3 years.
Croatian: Bolesnici su randomizirani u skupine koje su dnevno primale 75 mg klopidogrela ili 325 mg acetilsalicilatne kiseline te su praćeni od 1 do 3 godine.
English: As a precaution concomitant use of strong or moderate CYP2C19 inhibitors should be discouraged (see section 4.5 for a list of CYP2C19 inhibitors, see also section 5.2).
Croatian: Kao mjera opreza, ne preporučuje se istodobna primjena lijekova koji su jaki ili umjereni inhibitori CYP2C19 (za popis inhibitora CYP2C19 vidjeti dio 4.5, također vidjeti dio 5.2).
English: If you forget for more than 12 hours, simply take the next single dose at the usual time.
Croatian: Ukoliko se ne sjetite propuštene doze u roku od 12 sati, uzmite sljedeću dozu u uobičajeno vrijeme.
English: Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.
Croatian: Klopidogrel, također, inhibira agregaciju trombocita induciranu drugim agonistima, pored ADP-a i to blokiranjem pojačavanja aktivacije trombocita oslobođenim ADP-om.
English: Acute liver failure, hepatitis, abnormal liver function test
Croatian: Poremećaji jetre i žuči akutno zatajenje jetre, hepatitis, abnormalni nalazi jetrene funkcije
English: (98.1%) in the de-escalated DAPT group and 318 patients (98.5%) in the unchanged DAPT group.
Croatian: Nakon godine dana provedeno je praćenje 316 bolesnika (98,1%) u skupini sa de-eskaliranim DAPT-om i 318 bolesnika (98,5%) u skupini sa nepromijenjenim DAPT-om.
English: • Within less than 12 hours after regular scheduled time: patients should take the dose immediately and then take the next dose at the regular scheduled time.
Croatian: Propuštena doza: - Ako je prošlo manje od 12 sati nakon uobičajenog termina uzimanja lijeka: bolesnik treba odmah uzeti dozu, a sljedeću dozu treba uzeti prema uobičajenom rasporedu.
English: If you stop taking Clopidogrel Krka d.d.
Croatian: Ako prestanete uzimati Clopidogrel Krka d.d.
English: The number of patients experiencing the primary endpoint [cardiovascular (CV) death, myocardial infarction (MI), or stroke] was 582 (9.3%) in the clopidogrel-treated group and 719 (11.4%) in the placebo-treated group, a 20% relative risk reduction (95% CI of 10%-28%; p=0.00009) for the clopidogrel-treated group (17% relative risk reduction when patients were treated conservatively, 29% when they underwent percutaneous transluminal coronary angioplasty (PTCA) with or without stent and 10% when they underwent coronary artery bypass graft (CABG)).
Croatian: Broj bolesnika koji su doživjeli primarni ishod [kardiovaskularna smrt, infarkt miokarda ili moždani udar] bio je 582 (9,3%) u skupini koja je primala klopidogrel i 719 (11,4%) u skupini koja je primala placebo, uz 20%-tno smanjenje relativnog rizika (95% CI od 10% do 28%; p=0,00009) u skupini koja se liječila klopidogrelom (17% smanjenje relativnoga rizika u bolesnika koji su liječeni konzervativno, 29% u bolesnika podvrgnutih perkutanoj transluminalnoj koronarnoj angioplastici (PTCA) s ili bez ugradnje stenta i 10% za bolesnike kojima je obavljeno aortokoronarno premoštenje (CABG, engl.
English: Patients received clopidogrel (300 mg loading dose, followed by 75 mg/day, n=1752) or placebo (n=1739), both in combination with ASA (150 to 325 mg as a loading dose, followed by 75 to 162 mg/day), a fibrinolytic agent and, when appropriate, heparin.
Croatian: Bolesnici su primali klopidogrel (najprije udarnu dozu od 300 mg, a nakon toga dozu od 75 mg na dan, n=1752) ili placebo (n=1739), oboje u kombinaciji s ASK (150 do 325 mg kao udarna doza nakon čega je slijedila doza od 75 do 162 mg na dan), fibrinolitik i, po potrebi, heparin.
English: In patients who were enrolled in the trial on the sole basis of a recent myocardial infarction, clopidogrel was numerically inferior, but not statistically different from ASA (RRR =
Croatian: U bolesnika koji su u studiju uključeni samo zbog nedavnog infarkta miokarda, klopidogrel je bio brojčano slabiji, ali se statistički nije razlikovao od ASK (RRR = -4,0%; CI: -22,5 do 11,7 [p=0,639]).
English: If you forget to take Clopidogrel Krka d.d.
Croatian: Ako ste zaboravili uzeti Clopidogrel Krka d.d.
English: Patients were randomized to receive either prasugrel 5 or 10 mg/d (Days 0-14) (n=1309), or prasugrel 5 or 10 mg/d (Days 0-7) then de-escalated to clopidogrel 75 mg/d (Days 8-14) (n=1309), in combination with ASA (<100 mg/day).
Croatian: Bolesnici su bili randomizirani tako da primaju prasugrel u dozi od 5 ili 10 mg/dan (dan 0-14) (n=1309) ili prasugrel u dozi od 5 ili 10 mg/dan (dan 0-7) nakon čega su prebačeni na de-eskaliranu terapiju - klopidogrel u dozi od 75 mg/dan (dan 8-14) (n=1309) u kombinaciji s acetilsalicilatnom kiselinom (< 100 mg/dan).
English: Therapeutic experience is limited in patients with moderate hepatic disease who may have bleeding diatheses (see section 4.4).
Croatian: Terapijsko iskustvo u bolesnika s umjereno narušenom funkcijom jetre koji mogu imati hemoragijsku dijatezu je ograničeno (vidjeti dio 4.4).
English: As a precaution, concomitant use of omeprazole or esomeprazole should be discouraged (see section 4.4).
Croatian: Kao mjera opreza, ne preporučuje se istodobna primjena s omeprazolom ili esomeprazolom (vidjeti dio 4.4).
English: Other medicines and Clopidogrel Krka d.d.
Croatian: Drugi lijekovi i Clopidogrel
English: Therefore, concomitant use should be undertaken with caution (see section 4.4).
Croatian: Zbog toga, kod istodobne primjene potreban je oprez (vidjeti dio 4.4).
English: Patients were randomised to clopidogrel (300 mg loading dose followed by 75 mg/day, N=6,259) or placebo (N=6,303), both given in combination with ASA (75-325 mg once daily) and other standard therapies.
Croatian: Bolesnici su randomizirani u skupine koje su primale klopidogrel (udarna doza od 300 mg, a nakon toga 75 mg/dan, N=6259) ili placebo (N=6303), oboje u kombinaciji s ASK (75 do 325 mg jedanput dnevno) i drugom standardnom terapijom.
English: 75 mg film-coated tablets clopidogrel
Croatian: Clopidogrel Krka d.d. 75 mg filmom obložene tablete klopidogrel
English: The number of patients who reached the primary endpoint (time to first occurrence of stroke, MI, non-CNS systemic embolism or vascular death) was 832 (22.1%) in the group treated with clopidogrel + ASA and 924 (24.4%) in the placebo + ASA group (relative risk reduction of 11.1%; 95% CI of 2.4% to 19.1%; p=0.013), primarily due to a large reduction in the incidence of strokes.
Croatian: Broj bolesnika koji su dostigli primarni ishod (vrijeme do prve pojave moždanog udara, infarkta miokarda, ne-CNS sistemske embolije ili smrti od vaskularnog uzroka) bio je 832 (22,1%) u skupini liječenoj klopidogrelom + ASK te 924 (24,4%) u skupini placebo + ASK (relativno smanjenje rizika od 11,1%; 95% CI od 2,4% do 19,1%; p=0,013), primarno zbog velikog smanjenja incidencije moždanih udara.
English: If you become pregnant while taking Clopidogrel Krka d.d., consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant.
Croatian: Ako ste trudni ili sumnjate na trudnoću, obavjestite svog liječnika ili ljekarnika prije nego što uzmete Clopidogrel Krka d.d. Ako zatrudnite za vrijeme uzimanja Clopidogrela Krka d.d., odmah se posavjetujte s liječnikom, jer nije preporučeno uzimati klopidogrel za vrijeme trudnoće.
English: Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks The benefit of the combination of clopidogrel with ASA beyond four weeks has not been studied in this setting (see section 5.1).
Croatian: Kombinirano liječenje treba započeti što je ranije moguće nakon pojave simptoma i nastaviti kroz najmanje 4 tjedna.
English: Clopidogrel Krka d.d.
Croatian: Krka d.d.
English: Consequently, NSAIDs including Cox-2 inhibitors and clopidogrel should be co-administered with caution (see section 4.4).
Croatian: Stoga je potreban oprez pri istodobnoj primjeni NSAIL, uključujući Cox-2 inhibitore, i klopidogrela (vidjeti dio 4.4).
English: Respiratory tract bleeding (haemoptysis, pulmonary haemorrhage), bronchospasm, interstitial pneumonitis, eosinophilic pneumonia
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja epistaksa krvarenje u dišnome sustavu (hemoptiza, plućno krvarenje), bronhospazam, intersticijski pneumonitis, eozinofilna pneumonija
English: If HPR≥46 units, the patients were escalated back to prasugrel 5 or 10 mg/d for 11.5 months; if HPR<46 units, the patients continued on clopidogrel 75 mg/d for 11.5 months.
Croatian: Ako je HPR bio < 46 jedinica bolesnici su nastavili liječenje klopidogrelom u dozi od 75 mg/dan još 11,5 mjeseci.
English: with food and drink Clopidogrel Krka d.d.
Croatian: Clopidogrel Krka d.d. s hranom i pićem Clopidogrel Krka d.d. se može uzimati s obrokom ili bez obroka.
English: Patients were required to have either ECG changes compatible with new ischaemia or elevated cardiac enzymes or troponin I or T to at least twice the upper limit of normal.
Croatian: Uključujući kriteriji su bili promjene u EKG-u povezane s novom ishemijom ili povećane vrijednosti srčanih enzima, ili troponin
English: The active metabolite is formed mostly by CYP2C19 with contributions from several other CYP enzymes, including CYP1A2, CYP2B6 and CYP3A4.The active thiol metabolite which has been isolated in vitro, binds rapidly and irreversibly to platelet receptors, thus inhibiting platelet aggregation.
Croatian: Aktivni metabolit nastaje većinom putem CYP2C19 uz sudjelovanje nekoliko drugih CYP enzima, uključujući CYP1A2, CYP2B6 i CYP3A4.
English: How to take Clopidogrel Krka d.d.
Croatian: Kako uzimati Clopidogrel Krka d.d.
English: The de-escalated patients underwent high platelet reactivity (HPR) testing.
Croatian: Bolesnici na de-eskaliranoj terapiji bili su podvrgnuti ispitivanju visoke reaktivnosti trombocita (engl.
English: Method of administration For oral use.
Croatian: Za peroralnu primjenu.
English: • Renal impairment Therapeutic experience is limited in patients with renal impairment (see section 4.4).
Croatian: - Oštećenje funkcije bubrega Terapijsko iskustvo u bolesnika s narušenom funkcijom bubrega je ograničeno (vidjeti dio 4.4).
English: Patients on aspirin and a more potent P2Y12 blocker and without adverse event at one month were assigned to switch to fixed-dose aspirin plus clopidogrel (de-escalated dual antiplatelet therapy (DAPT)) or continuation of their drug regimen (unchanged DAPT).
Croatian: Bolesnicima koji su primali acetilsalicilatnu kiselinu i potentniji blokator P2Y12 te koji nisu imali štetne događaje prvih mjesec dana dodijeljen je ili prelazak na fiksnu dozu acetilsalicilatne kiseline i klopidogrela (de-eskalirana dvojna antitrombocitna terapija - engl.
English: The number of patients experiencing the co-primary endpoint (CV death, MI, stroke or refractory ischaemia) was 1,035 (16.5%) in the clopidogrel-treated group and 1,187 (18.8%) in the placebo-treated group, a 14% relative risk reduction (95% CI of 6%-21%, p=0.0005) for the clopidogrel-treated group.
Croatian: Broj bolesnika koji je doživio koprimarni ishod (kardiovaskularna smrt, infarkt miokarda, moždani udar ili refraktorna ishemija) bio je 1035 (16,5%) u skupini koja je primala klopidogrel, a 1187 (18,8%) u skupini koja je primala placebo, što znači smanjenje relativnoga rizika od 14% (95% CI: 6% do 21%, p=0,0005) u skupini koja je primala klopidogrel.
English: SSRIs: since SSRIs affect platelet activation and increase the risk of bleeding, the concomitant administration of SSRIs with clopidogrel should be undertaken with caution.
Croatian: Selektivni inhibitori ponovne pohrane serotonina (SSRI): budući da lijekovi iz skupine SSRI utječu na aktivaciju trombocita i povećavaju rizik od krvarenja, potreban je oprez prilikom istodobne primjene SSRI i klopidogrela.
English: - carbamazepine a medicine to treat some forms of epilepsy, - moclobemide, medicine to treat depression, - repaglinide, medicine to treat diabetes, - paclitaxel, medicine to treat cancer, - anti-retroviral medicines (medicines to treat HIV infections).
Croatian: - paklitaksel, lijek za liječenje raka, - antiretrovirusne lijekove (lijekovi za liječenje infekcije HIV-om).
English: The primary outcome, a composite of cardiovascular death, stroke, urgent revascularization, and BARC (Bleeding Academic Research Consortium) bleeding ≥2 at 1 year post ACS, occurred in 43 patients (13.4%) in the de-escalated DAPT group and in 85 patients (26.3%) in the unchanged DAPT group (p<0.01).
Croatian: Bleeding Academic Reasearch Consortium) stupnja krvarenja ≥ 2 u prvoj godini nakon akutnog koronarnog sindroma dogodio se u 43 bolesnika (13,4%) u skupini sa de-eskaliranim DAPT-om i u 85 bolesnika (26,3%) u skupini s nepromijenjenim DAPT-om.
English: 75 mg film-coated tablets
Croatian: Clopidogrel Krka d.d. 75 mg filmom obložene tablete
English: IJ
Croatian: E.
English: This randomized, open-label trial included 2,610 biomarker-positive ACS patients after successful PCI.
Croatian: Ukupno 2 610 bolesnika s akutnim koronarnim sindromom s pozitivnim biomarkerima bilo je uključeno u randomizirano, otvoreno ispitivanje nakon uspješne perkutane koronarne intervencije.
English: The recommended dose, including for patients with a condition called ‘atrial fibrillation' (an irregular heartbeat), is one 75 mg tablet of Clopidogrel Krka d.d.
Croatian: Preporučena doza, uključujući za bolesnike sa stanjem zvanim "fibrilacija atrija" (nepravilni otkucaji srca), je jedna tableta Clopidogrela Krka d.d. od 75 mg dnevno koja se uzima kroz usta, s obrokom ili bez obroka, i u isto vrijeme svaki dan.
English: The ACTIVE-W study demonstrated that anticoagulant treatment with vitamin K antagonists was more effective than with clopidogrel and ASA.
Croatian: Studija ACTIVE-W pokazala je da je antikoagulantna terapija s antagonistima vitamina
English: In the intention to treat analysis, 939 events were observed in the clopidogrel group and 1,020 events with ASA (relative risk reduction (RRR) 8.7%, [95% CI: 0.2 to 16.4]; p = 0.045), which corresponds, for every 1000 patients treated for 2 years, to 10 [CI: 0 to 20] additional patients being prevented from experiencing a new ischaemic event.
Croatian: U analizi ITT (engl. 'intention to treat') zabilježeno je 939 slučajeva u skupini koja je primala klopidogrel, a 1020 u skupini koja je primala ASK (realtivno smanjenje rizika, RRR - engl. relative risk reduction = 8,7% [95% CI: 0,2 do 16,4]; p=0,045) što, odgovara broju od dodatnih 10 bolesnika kojima je spriječen novi ishemijski događaj, na svakih 1000 bolesnika liječenih 2 godine [CI: 0 do 20]. Analiza ukupne smrtnosti, sekundarnog ishoda studije, nije pokazala značajnu razliku između klopidogrela (5,8%) i ASK (6,0%).
English: As a precaution concomitant use of strong or moderate CYP2C19 inhibitors should be discouraged (see sections 4.4 and 5.2).
Croatian: Kao mjera opreza, ne preporučuje se istodobna primjena klopidogrela i lijekova koji su jaki ili umjereni inhibitori CYP2C19 (vidjeti dio 4.4. i 5.2.).
English: Clinical trial data support use up to 12 months, and the maximum benefit was seen at 3 months (see section 5.1).
Croatian: a najveći učinak zabilježen je u trećem mjesecu liječenja (vidjeti dio 5.1).
English: However, patients entered into clinical trials with clopidogrel received a variety of concomitant medicinal products including diuretics, beta blockers, ACEI, calcium antagonists, cholesterol lowering agents, coronary vasodilators, antidiabetic agents
Croatian: Međutim, bolesnici koji su sudjelovali u kliničkim ispitivanjima s klopidogrelom istodobno su primali niz lijekova, među kojima su bili diuretici, beta blokatori, ACE inhibitori, antagonisti kalcija, lijekovi za snižavanje kolesterola, koronarni vazodilatatori, antidijabetici (uključujući inzulin), antiepileptici te antagonisti glikoproteina IIb/IIIa, bez znakova klinički značajnih štetnih interakcija.
English: How to store Clopidogrel Krka d.d.
Croatian: Kako čuvati Clopidogrel Krka d.d.
English: If you experience prolonged bleeding when taking Clopidogrel Krka d.d.
Croatian: Ako pri uzimanju Clopidogrela Krka d.d. imate produljeno krvarenje
English: Contact your doctor or pharmacist before stopping.
Croatian: Prije prekida terapije kontaktirajte svog liječnika ili ljekarnika.
English: Thrombotic thrombocytopenic purpura (TTP) (see section 4.4), aplastic anaemia, pancytopenia, agranulocytosis, severe thrombocytopenia, acquired haemophilia A, granulocytopenia, anaemia
Croatian: Poremećaji krvi i limfnog sustava trombocitopenija, leukopenija, eozinofilija neutropenija, uključujući tešku neutropeniju trombotična trombocitopenična purpura (TTP) (vidjeti dio 4.4), aplastična anemija, pancitopenija, agranulocitoza, teška trombocitopenija, stečena hemofilija A, granulocitopenija, anemija
English: Headache, stomach ulcer, vomiting, nausea, constipation, excessive gas in stomach or intestines, rashes, itching, dizziness, sensation of tingling and numbness.
Croatian: Manje česte nuspojave (mogu se javiti u manje od 1 na 100 osoba): glavobolja, čir želuca, povraćanje, mučnina, zatvor, povećano stvaranje plinova u želucu ili crijevima, osip, svrbež, omaglica, osjećaj trnaca i utrnulosti.
English: ASA treatment group compared to the placebo + ASA group (1.4% versus 0.8%, respectively).
Croatian: U skupini klopidogrel + ASK zabilježen je veći broj intrakranijalnih krvarenja, u odnosu na skupinu placebo + ASK (1,4% naspram 0,8%).
English: Consequently, a direct effect (slight toxicity), or an indirect effect (low palatability) cannot be excluded.
Croatian: Stoga, ne može se isključiti izravni (slaba toksičnost) ili neizravni (loš okus) učinak.