FrancophonIA/ELRC3.0 huggingface dataset:
English: No relevant inhibition by telaprevir of CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1 isozymes was observed in vitro.
Danish: In vitro fandtes ingen relevant hæmning af CYP1A2-, CYP2A6-, CYP2B6-, CYP2C8-, CYP2C9-,
English: HCV RNA > 1,000 IU/ml at week 12 of treatment
Danish: HCV-RNA > 1.000 IE/ml i uge 12 af behandlingen Behandling med INCIVO gennemført
English: Table 1: Guidelines for discontinuation of INCIVO, Peginterferon Alfa, and Ribavirin treatment
Danish: Tabel 1: Vejledning i seponering af behandling med INCIVO, pegyleret interferon-alfa og ribavirin
English: - This medicine has been prescribed for you only.
Danish: - Lægen har ordineret INCIVO til dig personligt.
English: Other includes patients with detectable HCV RNA at their actual end of treatment but who did not have viral breakthrough, and patients with a missing HCV RNA assessment during planned follow-up.
Danish: Andet omfatter patienter med detekterbart HCV RNA på det faktiske tidspunkt for behandlingsafslutning, men som ikke fik et viralt gennembrud, samt patienter med manglende HCV RNA-vurdering under den planlagte opfølgning.
English: Peginterferon alfa-2a/peginterferon alfa-2b and ribavirin were used according to their relevant Summary of Product Characteristics.
Danish: Pegyleret interferon-alfa-2a/pegyleret interferon-alfa-2b og ribavirin blev anvendt som angivet i de
English: At baseline, 3 (8%) patients had bridging fibrosis and 2 (5%) patients had cirrhosis in the T12/PR48 arm.
Danish: I T12/PR48-gruppen havde 3 forsøgspersoner (8%) brofibrose ved baseline, og 2 forsøgspersoner (5%) havde cirrose.
English: In vitro studies Activity of telaprevir against HCV
Danish: Telaprevirs aktivitet mod hepatitis C
English: Treatment with INCIVO must be initiated in combination with peginterferon alfa and ribavirin and administered for 12 weeks with an additional 36 weeks of peginterferon alfa and ribavirin alone for a total treatment duration of 48 weeks.
Danish: Behandling med INCIVO skal indledes i kombination med pegyleret interferon alfa og ribavirin i 12 uger efterfulgt af pegyleret interferon alfa og ribavirin alene i yderligere 36 uger, dvs. en samlet behandlingsvarighed på 48 uger.
English: - INCIVO 750 mg every 8 hours with peginterferon alfa-2b 1.5 g/kg/week and ribavirin
Danish: - INCIVO 750 mg hver 8. time sammen med pegyleret interferon-alfa-2b 1,5 g/kg/uge og
English: Study HPC3006 was an open-label, Phase 3b study in treatment- naïve and treatment-experienced chronic genotype 1 HCV- infected patients who were first time liver transplant recipients and were on a stable regimen of the immunosuppressants tacrolimus or cyclosporine A. No patients had cirrhosis of the liver graft.
Danish: Studie HPC3006 var et åbent fase 3b-studie, der omfattede behandlingsnaive og behandlingserfarne patienter med kronisk HCV-genotype 1-infektion, som var førstegangs-levertransplantatmodtagere i stabil behandling med de immunsupprimerende midler tacrolimus eller ciclosporin.
English: You must read the package leaflets for peginterferon alfa and ribavirin for additional information.
Danish: Læs indlægssedlen for pegyleret interferon-alfa og ribavirin for at få yderligere oplysninger om dette.
English: It is not recommended to co-administer darunavir/ritonavir and telaprevir (see section 4.4).
Danish: Darunavir/ritonavir anbefales ikke anvendt sammen med telaprevir (se pkt.
English: Plasma HCV RNA values were measured using the COBAS
Danish: Plasmakoncentrationen af HCV-RNA
English: Table 17 shows the overall response rates in treatment- naïve and treatment-experienced chronic genotype 1 HCV- infected liver transplant recipients and by subgroup (patients receiving tacrolimus or cyclosporine A).
Danish: Tabel 17 viser de samlede responsrater hos behandlingsnaive og behandlingserfarne levertransplantatmodtagere med kronisk HCV-genotype 1-infektion samt efter undergruppe
English: Co-administration of domperidone with INCIVO should be avoided (see section 4.4).
Danish: Samtidig anvendelse af domperidon og INCIVO bør undgås (se pkt.
English: No adjustment of the buprenorphine dose is required when co-administered with telaprevir.
Danish: Det er ikke nødvendigt at ændre buprenorphindosis ved samtidig anvendelse af telaprevir.
English: On-treatment-virologic failure includes patients who met a protocol-defined virologic stopping rule and/or had viral
Danish: Virologisk svigt i løbet af behandlingen omfatter patienter, som mødte en virologisk stopregel fastlagt i protokollen
English: - INCIVO 1,125 mg every 12 hours with peginterferon alfa-2b 1.5 g/kg/week and ribavirin
Danish: - INCIVO 1.125 mg hver 12. time sammen med pegyleret interferon-alfa-2b 1,5 g/kg/uge og
English: phenytoin*
Danish: etravirin*
English: - INCIVO 1,125 mg every 12 hours with peginterferon alfa-2a 180 g/week and ribavirin
Danish: - INCIVO 1.125 mg hver 12. time sammen med pegyleret interferon-alfa-2a 180 g/uge og
English: versus 750 mg every 8 hours (q8h) were 1.08 (1.02; 1.13) for AUC24,ss, 0.878 (0.827; 0.930) for Ctrough,ss, and 1.18 (1.12;1.24) for Cmax,ss.
Danish: Baseret på en populationsfarmakokinetisk model af eksponeringen for telaprevir ved steady state var ratioerne af middelværdierne (fundet ved mindste kvadraters metode; 90% CI) af 1.125 mg to gange dagligt versus 750 mg hver 8. time 1,08 (1,02; 1,13) for AUC24,ss, 0,878 (0,827; 0,930) for Ctrough,ss, og 1,18
English: Desiccant (one pouch or two
Danish: Der er ilagt tørremiddel (en eller to
English: - low blood platelet count, decrease in lymphocytes (a type of white blood cell), decrease in thyroid gland activity, increase in uric acid in your blood, decrease in potassium in your blood,
Danish: Almindelige bivirkninger (forekommer hos færre end 1 ud af 10 behandlede) - svampeinfektion i munden - lavt antal blodplader, fald i lymfocytter (en type hvide blodlegemer), nedsat aktivitet af skjoldbruskkirtlen, forhøjet urinsyre i blodet, nedsat mængde kalium i blodet, forhøjet bilirubin i blodet
English: INCIVO co-administration with domperidone should be avoided (see section 4.5).
Danish: Samtidig anvendelse af INCIVO og domperidon bør undgås (se pkt.
English: ↑ alfentanil ↑ fentanyl
Danish: ↑ triazolam
English: RNA levels ≥ 800,000 IU/ml; 10.8% had bridging fibrosis; none had cirrhosis; 38.9% had HCV genotype 1a; 58.3% had HCV genotype 1b; 2.8% had HCV genotype 1d; 21.6% had IL28B genotype CC; 54.1% had IL28B genotype CT; 24.3% had IL28B genotype TT; 28.4% (n = 21) were HCV treatment- naïve; 71.6% (n = 53) were treatment-experienced [14.9% (n = 11) were prior relapsers; 40.5% (n = 30) were prior non-responders; 16.2% (n = 12) could not be classified]; median time since liver transplantation was 2.5 years (range: 0.6 to 9.5 years); 67.6% (n = 50) received tacrolimus; 32.4% (n = 24) received cyclosporine A.
Danish: 21,6% havde IL28Bgenotype CC, 54,1% havde IL28B-genotype CT, og 24,3% havde IL28B-genotype TT. 28,4% (n = 21) var HCV-behandlingsnaive, og 71,6% (n = 53) var behandlingserfarne [14,9% (n = 11) var tidligere relapsers, mens 40,5% (n = 30) var tidligere non-responders, og 16,2% (n = 12) kunne ikke klassificeres].
English: to treat fungal infections (antifungals)
Danish: til at behandle psykiske lidelser (antipsykotika)
English: Please check with your doctor and follow
Danish: Gå til kontrol hos din læge, og følg behandlingen i den anbefalede periode.
English: The potential clinical significance of these findings is uncertain.
Danish: Den potentielle kliniske betydning af
English: 73.8% (59/80) of patients in the pooled peginterferon alfa-2a group met the criteria (undetectable HCV RNA (target not detected) at week 4 through week 20) for the shortened 24 week peginterferon/ribavirin treatment duration versus 61.7% (50/81) of patients in the pooled
Danish: 73,8% af patienterne (59 ud af 80) i den poolede pegyleret interferon-alfa-2a-gruppe opfyldte kriterierne (ikke-detekterbart HCV-RNA (HCV-RNA ikke påvist) fra uge 4 t.o.m.
English: Naïve patients treated with either peginterferon alfa-2a/ribavirin (n = 80) or peginterferon alfa-2b/ribavirin (n = 81) in combination with INCIVO, in an open label study, had comparable SVR rates.
Danish: Naive patienter, der fik enten pegyleret interferon-alfa-2a/ribavirin (n = 80) eller pegyleret interferon-alfa
English: Examples are: blood count levels, thyroid (a gland in your neck that controls your metabolism) levels, liver and kidney
Danish: Eksempler på disse blodprøver: blodbillede, skjoldbruskkirtelhormoner (dannes i kirtel i halsen og regulerer stofskiftet), lever- og
English: T12/PR48: INCIVO for 12 weeks followed by placebo for 4 weeks, in combination with peginterferon alfa-2a and
Danish: T12/PR48: INCIVO i 12 uger efterfulgt af placebo i 4 uger i kombination med pegyleret interferon-alfa-2a og ribavirin i
English: ), in case a dose of INCIVO is missed within 6 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of INCIVO with food as soon as possible.
Danish: Patienter, der tager INCIVO to gange dagligt, skal informeres om, at hvis de glemmer at tage en dosis INCIVO, og det opdages inden for 6 timer efter det sædvanlige tidspunkt, skal den foreskrevne dosis INCIVO tages hurtigst muligt sammen med føde.
English: Concurrent administration of salmeterol and telaprevir is not recommended.
Danish: Salmeterol anbefales ikke anvendt sammen med telaprevir.
English: Manufacturer Janssen-Cilag SpA, Via C. Janssen,
Danish: Janssen-Cilag SpA Via M.Buonarroti, 23
English: No relevant inhibition by telaprevir of the organic cation transporter (OCT) OCT2 was observed in vitro.
Danish: In vitro fandtes der ingen relevant telaprevir-relateret hæmning af den organiske kation-transportør
English: Refer to the Summary of Product Characteristics for peginterferon alfa and ribavirin for a list of their contraindications since INCIVO must be used in combination with peginterferon alfa and ribavirin.
Danish: For en oversigt over kontraindikationerne for pegyleret interferon-alfa og ribavirin henvises til produktresuméerne for disse, eftersom INCIVO skal anvendes i kombination med pegyleret
English: - Patients with detectable HCV RNA at either weeks 4 or 12 receive an additional 36 weeks of peginterferon alfa and ribavirin alone for a total treatment duration of 48 weeks.
Danish: - Patienter med detekterbart HCV-RNA i enten uge 4 eller 12 skal behandles i yderligere 36 uger med pegyleret interferon-alfa og ribavirin alene, så den samlede behandlingsvarighed bliver
English: Extent and features of Cutaneous Reactions
Danish: Kutane reaktioner - omfang og symptomer
English: only includes data on patients who had week 4 HCV RNA available
Danish: Tidligere partial responders Tidligere null responders omfatter kun data om patienter med resultater for HCV-RNA i uge 4
English: Pbo/PR48: placebo for 16 weeks in combination with peginterferon alfa-2a and ribavirin for 48 weeks
Danish: Pbo/PR48: Placebo i 16 uger i kombination med pegyleret interferon-alfa-2a og ribavirin i 48 uger.
English: If the missed dose is noticed more than 6 hours after the time INCIVO should be taken, the missed dose should be skipped and the patient should resume the normal dosing schedule.
Danish: Hvis det først opdages mere end 6 timer efter det sædvanlige tidspunkt for indgift af INCIVO, skal den glemte dosis springes over, og det sædvanlige
English: to treat schizophrenia, bipolar disorder and major depressive disorder midazolam (taken by mouth), triazolam (taken to help you sleep and/or relieve anxiety (sedatives/hypnotics)
Danish: til behandling af skizofreni, bipolar (maniodepressiv) sygdom og svære depressive episoder sovemidler og/eller angstdæmmende midler til at behandle epileptiske anfald (antiepileptika)
English: Absorption
Danish: Brugsanvisning
English: Refer also to the Summary of Product Characteristics for peginterferon alfa and ribavirin for severe skin reactions associated with
Danish: Se også produktresuméerne for pegyleret interferon-alfa og ribavirin for alvorlige hudreaktioner i forbindelse
English: INCIVO
Danish: dabigatran
English: SVR rates for patients with or without cirrhosis Patients without cirrhosis 65.5% (38/58)
Danish: SVR-rater for patienter med eller uden cirrose
English: Clinical and laboratory monitoring for hyperbilirubinaemia is recommended (see section 4.4 and 4.8).
Danish: Klinisk kontrol og laboratorieundersøgelser for hyperbilirubinæmi anbefales (se pkt.
English: INCIVO in combination with peginterferon and ribavirin is not recommended in patients with platelets < 90,000/mm
Danish: Anvendelse af INCIVO i kombination med peginterferon og ribavirin anbefales ikke til patienter med
English: metformin to treat diabetes (antidiabetics)
Danish: methadon til afvænning fra opioidmisbrug (narkotikamisbrug)
English: INCIVO treatment completed Permanently discontinue treatment with INCIVO, peginterferon alfa, and ribavirin.
Danish: Seponeres permanent behandling med INCIVO, pegyleret interferon-alfa og ribavirin.
English: tenofovir disoproxil fumarate*
Danish: parenteral anvendelse af midazolam*
English: The 1,088 enrolled patients had a median age of 49 years (range: 18 to 69); 58% of the patients were male; 23% had a body mass index ≥ 30 kg/m2; 9% were Black; 11% were Hispanic or Latino; 77% had baseline HCV RNA levels ≥ 800,000 IU/ml; 15% had bridging fibrosis; 6% had cirrhosis; 59% had HCV genotype 1a; and 40% had HCV genotype 1b.
Danish: 58% af patienterne var mænd, 23% havde et body mass index ≥ 30 kg/m2, 9% var sorte, 11% var af latinamerikansk afstamning, 77% havde HCV-RNA ≥ 800.000 IE/ml ved baseline, 15% havde brofibrose, 6% havde cirrose, 59% havde HCV af genotype 1a og 40% havde HCV af genotype 1b.
English: If you take more INCIVO than you should
Danish: Hvis du holder op med at tage INCIVO
English: INCIVO must be used in combination with peginterferon alfa and ribavirin.
Danish: INCIVO skal anvendes i kombination med pegyleret interferon-alfa og ribavirin.
English: Discontinuation of INCIVO combination treatment is not
Danish: Virkningen på koncentrationer af ubundet telaprevir er
English: Drug interactions need to be carefully taken into account, see sections 4.4 and 4.5.
Danish: 4.5 skal følges nøje.
English: In patients with HCV RNA between 100 IU/ml and 1,000 IU/ml at week 12,
Danish: Hos patienter med HCV-RNA mellem 100 IE/ml og 1.000 IE/ml i uge 12 opnåedes SVR hos 2 ud af 8 patienter (25%).
English: Duration of treatment - Treatment-naïve adults and prior treatment relapsers Treatment with INCIVO must be initiated in combination with peginterferon alfa and ribavirin and administered for 12 weeks (see figure 1).
Danish: Behandlingen med INCIVO skal indledes i kombination med pegyleret interferon-alfa og ribavirin og gives i 12 uger (se figur 1).
English: Refer to the Summary of Product Characteristics for peginterferon alfa and ribavirin which must be
Danish: Se produktresuméerne for pegyleret interferon-alfa og ribavirin, som skal gives sammen med
English: Dose modification of INCIVO is not required when administered to hepatitis C patients with mild hepatic impairment (Child-Pugh A, score 5-6).
Danish: Dosismodifikation af INCIVO er ikke nødvendig, når lægemidlet anvendes til patienter med hepatitis C og let nedsat leverfunktion
English: Duration of treatment - Previously treated adults with prior partial or prior null response Treatment with INCIVO must be initiated in combination with peginterferon alfa and ribavirin and administered for 12 weeks, followed by peginterferon alfa and ribavirin therapy alone (without INCIVO) for a total treatment duration of 48 weeks (see figure 2).
Danish: Behandling med INCIVO skal indledes i kombination med pegyleret interferon-alfa og ribavirin og gives i 12 uger, hvorefter der behandles med pegyleret interferon-alfa og ribavirin alene (uden INCIVO), indtil den samlede behandlingsvarighed er 48 uger (se figur 2).
English: The 540 enrolled patients had a median age of 51 years (range: 19 to 70); 60% of the patients were male; 32% had a body mass index ≥ 30 kg/m2; 14% were Black; 10% were Hispanic or Latino; 82% had baseline HCV RNA levels > 800,000 IU/ml; 16% had bridging fibrosis; 11% had cirrhosis; 72% had HCV genotype 1a; and 27% had HCV genotype 1b.
Danish: 60% af patienterne var mænd, 32% havde et body mass index ≥ 30 kg/m2, 14% var sorte, 10% var af latinamerikansk afstamning, 82% havde HCV-RNA ≥ 800.000 IE/ml ved baseline, 16% havde brofibrose, 11% havde cirrose, 72% havde HCV af genotype 1a og 27% havde HCV af genotype 1b.
English: abacavir
Danish: abacavir zidovudin
English: For information on the use of INCIVO in combination with peginterferon alfa and ribavirin in treatment-naïve and treatment-experienced HCV-1 infected patients who were liver transplant recipients and were on a stable regimen of the immunosuppressants tacrolimus or cyclosporine A, see sections 4.2,
Danish: 4.2, 4.5, Immunsupprimerende midler, 4.8 og 5.1 for oplysninger om brugen af INCIVO i kombination med pegyleret interferon alfa og ribavirin til behandlingsnaive og behandlingserfarne HCV-1-inficerede patienter, som var levertransplantatmodtagere og i stabil behandling med de immunsupprimerende midler tacrolimus eller ciclosporin.
English: clarithromycin, erythromycin, telithromycin, troleandomycin to treat bacterial infections (antibacterials)
Danish: clarithromycin, erythromycin, telithromycin, troleandomycin til at behandle bakterielle infektioner (antibiotika) blodfortyndende midler til at forebygge blodpropper (antikoagulantia) til at behandle humørforandringer (antidepressiva) til at behandle diabetes (sukkersyge) (antidiabetika) til at behandle kvalme og opkastning (antiemetika) til at behandle svampeinfektioner (antimykotika)
English: Table 3: Adverse drug reactions to INCIVO (taken in combination with peginterferon alfa and ribavirin) in HCV-infected patients in clinical trials a and post-marketing Adverse Drug Reactions INCIVO, peginterferon alfa, and ribavirin combination therapy oral candidiasis anaemia thrombocytopenia b, lymphopenia hypothyroidism hyperuricaemia b, hypokalaemia gout dysgeusia, syncope
Danish: Tabel 3: Bivirkninger af INCIVO (taget i kombination med pegyleret interferon-alfa og ribavirin) hos HCV-inficerede patienter i kliniske studier a og efter markedsføring Bivirkninger
English: Caution is warranted, laboratory and clinical monitoring is recommended.
Danish: Forsigtighed tilrådes, og klinisk kontrol med laboratorieundersøgelser anbefales.
English: INCIVO in combination with peginterferon alfa and ribavirin was evaluated in 74 HCV-1 infected, post-liver transplant patients without cirrhosis receiving either tacrolimus or cyclosporine A. At the initiation of INCIVO treatment, doses of co-administered tacrolimus or cyclosporine A need to be markedly reduced, including a prolongation in the dosing interval for tacrolimus, in order to maintain therapeutic plasma concentrations of the immunosuppressant.
Danish: INCIVO i kombination med pegyleret interferon alfa og ribavirin blev evalueret hos 74 HCV-1inficerede levertransplanterede patienter uden cirrose, som fik enten tacrolimus eller ciclosporin.
English: Haemoglobin values of < 8.5 g/dl were observed in 8% of INCIVO combination treatment compared to 2% of patients receiving peginterferon alfa and ribavirin.
Danish: Hæmoglobinværdier < 8,5 g/dl blev observeret hos 8%, der fik INCIVO
English: Elderly
Danish: Anæmi
English: Hispanic Latino
Danish: filiāle Latvijā
English: IMMUNOSUPPRESSANTS
Danish: Levertransplantatmodtagere
English: AUC 0.80 (0.76-0.85) Cmax 0.79 (0.74-0.84) Cmin 0.85 (0.75-0.98) ↑ atazanavir AUC 1.17 (0.97-1.43) Cmax 0.85 (0.73-0.98) Cmin 1.85 (1.40-2.44) inhibition of CYP3A by telaprevir
Danish: AUC 1,17 (0,97-1,43) Cmax 0,85 (0,73-0,98) Cmin 1,85 (1,40-2,44) telaprevis hæmmer CYP3A
English: INCIVO must be taken in combination with peginterferon alfa and ribavirin.
Danish: INCIVO skal tages i kombination med pegyleret interferon-alfa og ribavirin.
English: Because INCIVO must be used in combination with peginterferon alfa and ribavirin, the contraindications and warnings applicable to those medicinal products are applicable to combination
Danish: Særlige krav vedrørende graviditet og kontraception Eftersom INCIVO skal anvendes i kombination med pegyleret interferon-alfa og ribavirin, gælder kontraindikationerne og advarslerne for disse lægemidler også for kombinationsbehandlingen.
English: For additional information, see sections 4.5 and 4.6.
Danish: 4.5 og 4.6.
English: - Anaemia (decrease in your red blood cells) Tell your doctor if you experience tiredness, weakness, shortness of breath, light-headedness, and/or the feeling of the heart racing.
Danish: Fortæl det til lægen, hvis du bliver træt eller svækket eller lider af kortåndethed, svimmelhed og/eller hjertebanken.
English: Among prior relapsers in the T12/PR24 treatment group who had undetectable HCV RNA
Danish: Blandt patienterne med tidligere relapse i T12/PR24-gruppen, som havde ikke-detekterbart HCV-RNA (HCV-RNA ikke påvist) i behandlingsuge 4 og 12, var SVR-raten
English: Prior Relapsers N = 29 % (n/N)
Danish: Tidligere behandlede patienter efter undergruppe Tidligere relapsers N = 29 % (n/N)
English: Refer to section 4.5 for established and other potentially significant drug-drug interactions.
Danish: Vedrørende påviste og andre potentielt signifikante lægemiddelinteraktioner henvises til pkt.
English: Following the end of the INCIVO treatment, please see the ribavirin package leaflet regarding continued contraception
Danish: Efter at du har gennemført INCIVO-behandlingen, kan du læse om det fortsatte behov for prævention i
English: If INCIVO is discontinued for anaemia, patients may continue treatment with peginterferon alfa and ribavirin.
Danish: behandling af anæmi, kan der fortsat behandles med pegyleret interferon-alfa og ribavirin.
English: HORMONAL CONTRACEPTIVES/OESTROGEN ethinylestradiol* norethindrone*
Danish: IMMUNSUPPRIMERENDE MIDLER ciclosporin* tacrolimus* sirolimus
English: See table 1 for Guidelines for Discontinuation of INCIVO, Peginterferon Alfa, and Ribavirin Treatment.
Danish: Se Vejledning i seponering af behandling med INCIVO, pegyleret interferon-alfa og ribavirin i tabel 1.
English: AUC 0.53 (0.47-0.60) Cmax 0.68 (0.60-0.77) Cmin 0.32 (0.25-0.42) ↑ phenytoin
Danish: AUC 0,80 (0,76-0,85) Cmax 0,79 (0,74-0,84) Cmin 0,85 (0,75-0,98) ↑ atazanavir
English: to treat some stomach conditions (gastrointestinal motility agents)
Danish: til at behandle visse mavesygdomme (midler, der påvirker mave-tarm-kanalens funktion)
English: Refer to the Summary of Product Characteristics for peginterferon alfa and ribavirin, including pregnancy testing requirements (see section 4.6).
Danish: Se produktresuméerne for pegyleret interferon-alfa og ribavirin inklusive behov for graviditetsprøver
English: INCIVO must be taken with peginterferon alfa and ribavirin to prevent treatment failure.
Danish: INCIVO skal tages sammen med pegyleret interferon-alfa og ribavirin for at forebygge
English: It is not recommended to co-administer fosamprenavir/ritonavir and telaprevir (see section 4.4).
Danish: Fosamprenavir/ritonavir anbefales ikke anvendt sammen med telaprevir (se pkt.
English: ↓ ethinylestradiol AUC 0.72 (0.69-0.75) Cmax 0.74 (0.68-0.80) Cmin 0.67 (0.63-0.71) ↔ norethindrone AUC 0.89 (0.86-0.93) Cmax 0.85 (0.81-0.89) Cmin 0.94 (0.87-1.00) mechanism unknown
Danish: AUC 0,68 (0,58-0,79) Cmax 0,79 (0,70-0,90) Cmin 0,53 (0,44-0,65) ↔ carbamazepin AUC 1,10 (0,99-1,23) Cmax 1,09 (0,98-1,21) Cmin 1,10 (0,97-1,24) carbamazepin inducerer CYP3A,
English: AUC 1.00 (0.94-1.07) Cmax 1.01 (0.96-1.05) Cmin 1.03 (0.93-1.14) ↑ tenofovir
Danish: ↑ ciclosporin AUC 4,64 (3,90-5,51) Cmax 1,32 (1,08-1,60) ↑ tacrolimus AUC 70,3 (52,9-93,4)** Cmax 9,35 (6,73-13,0)** ↑ sirolimus
English: Also contact your doctor immediately: - if your rash worsens, OR - if you develop other symptoms with a rash such as:
Danish: - hvis du får andre symptomer samtidig med udslættet såsom:
English: )/PR: INCIVO 1,125 mg twice daily for 12 weeks with peginterferon alfa-2a and ribavirin for 24 or 48 weeks; T12(q8h)/PR: INCIVO 750 mg every 8 hours for 12 weeks with peginterferon alfa-2a and ribavirin for 24 or 48 weeks
Danish: )/PR: INCIVO 1.125 mg to gange dagligt i 12 uger med pegyleret interferon-alfa-2a og ribavirin i 24 eller 48 uger.