FrancophonIA/ELRC3.0 huggingface dataset:
English: Therefore antiplatelet therapies should not be discontinued (see sections above, 4.5 and 5.1.
Slovenian: Zato se antiagregacijskega zdravljenja ne sme ukiniti (glejte zgoraj in poglavji 4.5 in 5.1).
English: Etoricoxib may slightly increase your risk of heart attack and stroke and this is why it should not be used in those who have already had heart problems or stroke
Slovenian: Etorikoksib lahko rahlo poveča tveganje za pojav srčnega napada in možganske kapi, zato ga bolniki, ki so že imeli težave s srcem ali doživeli možgansko kap, ne smejo uporabljati.
English: <ARCOXIA> is administered orally and may be taken with or without food.
Slovenian: Zdravilo <ARCOXIA> je za peroralno uporabo in se lahko jemlje s hrano ali brez nje.
English: In addition to class warnings and contraindications, introduced for all COX-2 selective inhibitors, a contraindication in patients with hypertension whose blood pressure is not adequately controlled was included specifically for etoricoxib because of evidence of higher rates of cardiorenal events than other COX-2 inhibitor products.
Slovenian: Poleg skupinskih opozoril in kontraindikacij, uvedenih za vse selektivne zaviralce COX-2, se je pri bolnikih s povečanim krvnim tlakom, ki ni ustrezno nadzorovan, za etorikoksib zaradi dokazov o višjih stopnjah kardiorenalnih dogodkov v primerjavi z drugimi zdravili s selektivnimi zaviralci COX2 dodala posebna kontraindikacija.
English: Patients with significant risk factors for cardiovascular events (e.g. hypertension, hyperlipidaemia, diabetes mellitus, smoking) should only be treated with etoricoxib after careful consideration (see section 5.1).
Slovenian: Bolnike s pomembnimi dejavniki tveganja za srčno-žilne dogodke (npr. visok krvni tlak, hiperlipidemija, sladkorna bolezen, kajenje) lahko z etorikoksibom zdravimo le po skrbnem premisleku (glejte poglavje 5.1).
English: Aluminum/aluminium blisters (unit doses) in packs of 50 or 100 tablets.
Slovenian: Aluminij/aluminij pretisni omoti (enoodmerni) v škatlah po 50 ali 100 tablet.
English: Cardiorenal Events:
Slovenian: Kardiorenalni dogodki:
English: In clinical studies, administration of single doses of etoricoxib up to 500 mg and multiple doses up to 150 mg/day for 21 days did not result in significant toxicity.
Slovenian: V kliničnih študijah enkratni odmerki etorikoksiba do 500 mg in večkratni odmerki do 150 mg dnevno 21 dni niso imeli pomembnih toksičnih učinkov.
English: In preclinical studies, etoricoxib has been demonstrated not to be genotoxic.
Slovenian: V predkliničnih študijah se je pokazalo, da etorikoksib ni genotoksičen.
English: If you do take too many <ARCOXIA> tablets, you should seek medical attention immediately.
Slovenian: Če ste pomotoma vzeli prevelik odmerek zdravila <ARCOXIA>, nemudoma poiščite zdravniško pomoč.
English: While knowledge about effects of multiple sulfotransferases is presently limited and the clinical consequences for many drugs are still being examined, it may be prudent to exercise care when administering etoricoxib concurrently with other drugs primarily metabolised by human sulfotransferases (e.g., oral salbutamol and minoxidil).
Slovenian: Ker je poznavanje učinkov različnih sulfotransferaz še omejeno in ker klinične posledice velikega števila zdravil še preučujejo, je umestna previdnost pri sočasni uporabi etorikoksiba in drugih zdravil, ki jih primarno presnavljajo človeške sulfotransferaze (npr. peroralni salbutamol in minoksidil).
English: Cardiovascular safety results:
Slovenian: Rezultati o kardiovaskularni varnosti:
English: • if you are allergic to non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin and COX-2 inhibitors (see Possible Side Effects, section 4)
Slovenian: • če ste alergični na nesteroidne antirevmatike (NSAIR-e), vključno z acetilsalicilno kislino in z zaviralci COX-2 (glejte poglavje 4 Možni neželeni učinki).
English: Etoricoxib is excreted in the milk of lactating rats at concentrations approximately two-fold those in plasma.
Slovenian: Etorikoksib se izloča v mleko doječih podgan v koncentracijah, ki so približno dvakrat večje od koncentracij v plazmi.
English: COX-2 has been identified in tissue around gastric ulcers in man but its relevance to ulcer healing has not been established.
Slovenian: COX-2 so odkrili v tkivu okoli želodčnih razjed pri človeku, vendar pa njenega pomena za celjenje razjed še niso dokazali.
English: Do not take <ARCOXIA>:
Slovenian: Ne uporabljajte zdravila <ARCOXIA>:
English: Both referral procedures pertained to the safety of the COX-2 inhibitor products, including etoricoxib, with a particular focus on gastrointestinal (GI) and cardiovascular (CV) safety.
Slovenian: Oba napotitvena postopka sta se nanašala na varnost zdravil z zaviralci COX-2, vključno z etorikoksibom, s posebnim poudarkom na gastrointestinalni in kardiovaskularni varnosti.
English: Use of gastroprotective agents and low dose aspirin were permitted in the studies.
Slovenian: V študijah je bila dovoljena uporaba gastroprotektivnih zdravil in majhnega odmerka acetilsalicilne kisline.
English: <ARCOXIA> tablets contain lactose.
Slovenian: Tablete zdravila <ARCOXIA> vsebujejo laktozo.
English: <ARCOXIA> works equally well in older and younger adult patients.
Slovenian: Pri starejših odraslih bolnikih je zdravilo<ARCOXIA> enako učinkovito kot pri mlajših odraslih bolnikih.
English: The effect of the recommended chronic doses of etoricoxib (30, 60, and 90 mg) has not been studied.
Slovenian: Učinka priporočenih odmerkov etorikoksiba za dolgotrajno zdravljenje (60 in 90 mg) niso preučevali.
English: Therefore, hypertension should be controlled before treatment with etoricoxib (see section 4.3) and special attention should be paid to blood pressure monitoring during treatment with etoricoxib.
Slovenian: Zato mora biti visok krvni tlak kontroliran že pred zdravljenjem z etorikoksibom (glejte poglavje 4.3) in med zdravljenjem z etorikoksibom je treba posebno pozornost nameniti kontroli krvnega tlaka.
English: No dosage adjustment is necessary for elderly patients.
Slovenian: Pri starejših bolnikih odmerkov ni treba prilagoditi.
English: Total number of patients randomised, n= 17412 on etoricoxib and 17289 on diclofenac.
Slovenian: Skupno število randomiziranih bolnikov: n = 17.412 za etorikoksib in 17.289 za diklofenak.
English: The CHMP concluded on 26 June 2008 that the data confirm the known relatively adverse renovascular safety profile of etoricoxib (hypertension, oedema and congestive heart failure), but similar CV thrombotic risk as diclofenac and some degree of upper GI safety advantage over naproxen and diclofenac (though no particular lower GI safety advantage).
Slovenian: CHMP je dne 26. junija 2008 zaključil, da podatki potrjujejo znan, sorazmerno škodljiv renovaskularni varnostni profil etorikoksiba (povišan krvni tlak, edemi in kongestivna odpoved srca) ter podobno kardiovaskularno trombotično ogroženost kot pri uporabi učinkovine diklofenak in nekoliko večjo zgornjo varnost glede ogroženosti zgornjih prebavil v primerjavi z učinkovinama naproksen in diklofenak (vendar nobene manjše ogroženosti za spodnja prebavila).
English: These increases in estrogenic concentration should be taken into consideration when selecting post-menopausal hormone therapy for use with etoricoxib because the increase in oestrogen exposure might increase the risk of adverse events associated with HRT.
Slovenian: Ta povečanja koncentracije estrogena je treba upoštevati pri izboru pomenopavzalnega hormonskega zdravljenja pri bolnicah, ki jemljejo etorikoksib, saj se pri večji izpostavljenosti estrogenu poveča tveganje za pojav neželenih učinkov, povezanih s hormonskim nadomestnim zdravljenjem.
English: In some patients with compromised renal function (e.g. dehydrated patients or elderly patients with compromised renal function) the co-administration of an ACE inhibitor or Angiotensin II antagonist and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Slovenian: Pri nekaterih bolnikih z zmanjšano ledvično funkcijo (npr. dehidriranih bolnikih ali starejših bolnikih z zmanjšano ledvično funkcijo) se lahko pri sočasni uporabi zaviralca ACE ali antagonista angiotenzina II in učinkovin, ki zavirajo ciklooksigenazo, ledvična funkcija dodatno poslabša, vključno z možno akutno odpovedjo ledvic, ki pa je običajno reverzibilna.
English: Therefore, patients receiving oral anticoagulants should be closely monitored for their prothrombin time INR, particularly in the first few days when therapy with etoricoxib is initiated or the dose of etoricoxib is changed (see section 4.4).
Slovenian: Zato je treba pri bolnikih, ki prejemajo peroralne antikoagulante, skrbno spremljati protrombinski čas, izražen z INR, še posebej prvih nekaj dni po začetku zdravljenja ali po spremembi odmerka etorikoksiba (glejte poglavje 4.4).
English: The CHMP assessed efficacy data submitted for AS and safety data collected regarding AS, and also in the rheumatoid arthritis population for which the same dose is approved for treatment.
Slovenian: Odbor CHMP je ocenil predložene podatke o učinkovitosti pri zdravljenju ankilozirajočega spondilitisa ter podatke o varnosti v zvezi z ankilozirajočim spondilitisom in pri populaciji z revmatoidnim artritisom, pri kateri je za zdravljenje določen enak odmerek.
English: If you become pregnant, stop taking the tablets and consult your doctor.
Slovenian: Če zanosite, tablete prenehajte jemati in se posvetujte z zdravnikom.
English: During the assessment of the procedure, concerns were raised over the long-term safety of etoricoxib 90mg in patients with AS.
Slovenian: Med postopkom vrednotenja so se pojavila vprašanja v zvezi z varnostjo dolgotrajne uporabe etorikoksiba 90 mg pri bolnikih z ankilozirajočim spondilitisom.
English: Clinical trials suggest that the selective COX-2 inhibitor class of drugs may be associated with a risk of thrombotic events (especially myocardial infarction (MI) and stroke), relative to placebo and some NSAIDs.
Slovenian: Klinične študije kažejo, da je razred zdravil selektivnih zaviralcev COX-2 lahko povezan s tveganjem za trombotične dogodke (posebno za miokardni infarkt (MI) in možgansko kap) glede na placebo in nekatere NSAR-e.
English: Cyclosporin and tacrolimus: Although this interaction has not been studied with etoricoxib, coadministration of cyclosporin or tacrolimus with any NSAID may increase the nephrotoxic effect of cyclosporin or tacrolimus.
Slovenian: Ciklosporin in takrolimus: Te interakcije z etorikoksibom niso preučevali, vendar pa se pri sočasni uporabi ciklosporina ali takrolimusa in kateregakoli NSAR-a lahko poveča nefrotoksični učinek ciklosporina ali takrolimusa.
English: The clinical benefit of etoricoxib was observed as early as the second day of therapy after initiation of treatment and was maintained throughout the 52-week treatment period.
Slovenian: Klinično korist etorikoksiba so opazili že drugi dan po začetku zdravljenja, vzdrževala pa se je celih 52 tednov zdravljenja.
English: These led to updates of the product information to include class warnings on the risk of CV thrombotic, GI and severe skin reactions with COX-2 selective inhibitors.
Slovenian: To je pripeljalo do posodobitve informacij o zdravilu, ki so sedaj vsebovale skupinska opozorila o tveganju za trombotične reakcije srca in ožilja ter hude reakcije prebavil in kože zaradi selektivnih zaviralcev COX-2.
English: Osteoarthritis
Slovenian: Osteoartroza
English: Uncommon: proteinuria.
Slovenian: Občasne: proteinurija
English: • if your doctor has diagnosed heart problems including heart failure (moderate or severe types), angina (chest pain) or if you have had a heart attack, bypass surgery, peripheral arterial disease (poor circulation in legs or feet due to narrow or blocked arteries), or any kind of stroke (including ministroke, transient ischaemic attack or TIA).
Slovenian: • če je zdravnik pri vas ugotovil bolezni srca, vključno s srčnim popuščanjem (zmerno ali hudo obliko), angino pektoris (bolečina v prsnem košu), ali če ste kdaj imeli srčni napad, obvodno operacijo koronark ("bypass"), bolezen perifernih arterij (slaba prekrvavitev v nogah ali stopalih zaradi zožanih ali zamašenih arterij) ali možgansko kap (vključno z malo možgansko kapjo ali tranzitorno ishemično atako (TIA)).
English: Pregnancy and breast-feeding <ARCOXIA> tablets must not be taken during pregnancy.
Slovenian: Tablet zdravila <ARCOXIA> med nosečnostjo ne smete jemati.
English: If a woman becomes pregnant during treatment, etoricoxib must be discontinued.
Slovenian: Če ženska med zdravljenjem zanosi, je treba etorikoksib ukiniti.
English: • methotrexate (a drug used for suppressing the immune system, and often used in rheumatoid arthritis)
Slovenian: • metotreksat (zdravilo za zaviranje imunskega sistema, ki se pogosto uporablja pri zdravljenju revmatoidnega artritisa),
English: Tablet coating: carnauba wax, lactose monohydrate, hypromellose, titanium dioxide (E171), triacetin.
Slovenian: Obloga tablete: karnauba vosek, laktoza monohidrat, hipromeloza, titanov dioksid (E171), triacetin.
English: • ciclosporin or tacrolimus (drugs used for suppressing the immune system)
Slovenian: • ciklosporin ali takrolimus (zdravili za zaviranje imunskega sistema),
English: • minoxidil (a drug used to treat high blood pressure)
Slovenian: • minoksidil (zdravilo za zdravljenje visokega krvnega tlaka),
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze zdravila ne smejo jemati.
English: No clinical data on exposed pregnancies are available for etoricoxib.
Slovenian: Klinični podatki o izpostavljenosti etorikoksibu med nosečnostjo niso na voljo.
English: In clinical trials, etoricoxib was evaluated for safety in 7152 individuals, including 4614 patients with OA, RA, chronic low back pain or ankylosing spondylitis (approximately 600 patients with OA or RA were treated for one year or longer).
Slovenian: V kliničnih preskušanjih so varnost etorikoksiba ovrednotili pri 7.152 posameznikih, vključno s 4.614 bolniki z OA, RA, kronično bolečino v križu ali ankilozirajočim spondilitisom (približno 600 bolnikov z OA ali RA se je zdravilo eno leto ali več).
English: Dosing with food (a high-fat meal) had no effect on the extent of absorption of etoricoxib after administration of a 120-mg dose.
Slovenian: Jemanje s hrano (obrok z veliko maščobami) ni vplivalo na obseg absorpcije etorikoksiba po zaužitju 120 mg odmerka.
English: • lithium (a medicine used to treat some types of depression)
Slovenian: • litij (zdravilo za zdravljenje nekaterih oblik depresije),
English: <ARCOXIA> can mask or hide a fever, which is a sign of infection.
Slovenian: Zdravilo <ARCOXIA> lahko prikrije zvišano telesno temperaturo, ki je znak okužbe
English: • You have diabetes, high cholesterol, or are a smoker.
Slovenian: • imate sladkorno bolezen, povišan holesterol ali kadite.
English: Marketing Authorisation Holder and Manufacturer [See Annex 1-To be filled in nationally] {Name and address} {tel} {fax} {e-mail}
Slovenian: Imetnik dovoljenja za promet z zdravilom in izdelovalec: [Glejte Dodatek I - Izpolni država članica] {Ime in naslov} {tel.} {fax} {e-mail}
English: The following serious undesirable effects have been reported in association with the use of NSAIDs and cannot be ruled out for etoricoxib: nephrotoxicity including interstitial nephritis and nephrotic syndrome; hepatotoxicity including hepatic failure, jaundice and pancreatitis.
Slovenian: V povezavi z uporabo NSAR-ov so poročali o naslednjih resnih neželenih učinkih, ki jih pri etorikoksibu ne moremo izključiti: nefrotoksičnosti, vključno z intersticijskim nefritisom in nefrotskim sindromom, hepatotoksičnosti, vključno z odpovedjo jeter in zlatenico ter pankreatitisu.
English: Based on the review of the available data, the CHMP considers that the benefits of etoricoxib outweigh the risks in the treatment of ankylosing spondylitis.
Slovenian: Na podlagi pregleda dostopnih podatkov je CHMP menil, da so koristi etorikoksiba pri zdravljenju ankilozirajočega spondilitisa večje od z njim povezanih tveganj.
English: * Based on analyses of long-term placebo and active controlled clinical trials, selective COX-2 inhibitors have been associated with an increased risk of serious thrombotic arterial events, including myocardial infarction and stroke.
Slovenian: * Glede na rezultate dolgoročnih, s placebom in z drugim zdravilom nadzorovanih kliničnih preskušanj so bili nekateri selektivni zaviralci COX-2 povezani s povečanim tveganjem za pojav resnih arterijskih trombotičnih dogodkov, vključno z miokardnim infarktom in možgansko kapjo.
English: Data from clinical studies showed clinically meaningful treatment effect for the 90mg etoricoxib once daily dose for AS indications; however, some data are available to indicate that lower doses might also show effect.
Slovenian: Podatki iz kliničnih študij so kazali klinično pomembne učinke zdravljenja z 90-miligramskim odmerkom etorikoksiba enkrat dnevno pri indikacijah ankilozirajočega spondilitisa, na voljo pa so tudi podatki, ki kažejo, da so lahko tudi manjši odmerki učinkoviti.
English: Etoricoxib, as with other medicinal products inhibiting prostaglandin synthesis, may cause uterine inertia and premature closure of the ductus arteriosus during the last trimester.
Slovenian: Etorikoksib lahko tako kot druga zdravila, ki zavirajo sintezo prostaglandinov, v primeru uporabe med zadnjim trimesečjem nosečnosti povzroči inercijo maternice in prezgodnje zaprtje arterioznega duktusa.
English: • salbutamol tablets or oral solution (a medicine for asthma)
Slovenian: • salbutamol v obliki tablet ali peroralne raztopine (zdravilo za zdravljenje astme),
English: Some selective COX2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy.
Slovenian: Nekateri selektivni zaviralci COX-2 so bili povezani s povečanim tveganjem za neželene učinke na koži pri bolnikih, ki so v preteklosti imeli alergijo na katerokoli zdravilo.
English: Steady state concentrations of etoricoxib are reached within seven days of once daily administration of 120 mg, with an accumulation ratio of approximately 2, corresponding to a half-life of approximately 22 hours.
Slovenian: Koncentracije etorikoksiba v stanju dinamičnega ravnovesja se dosežejo v sedmih dneh pri odmerjanju 120 mg enkrat na dan. Akumulacijsko razmerje je približno 2, kar ustreza razpolovnemu času približno 22 ur.
English: 30 mg Aluminum/aluminium blisters in packs containing 7 and 28 tablets.
Slovenian: 30 mg Aluminij/aluminij pretisni omoti v škatlah po 7 ali 28 tablet.
English: If you forget to take <ARCOXIA>
Slovenian: Če ste pozabili vzeti zdravilo <ARCOXIA>
English: If you think any of these are relevant to you, do not take the tablets until you have consulted your doctor.
Slovenian: Če menite, da karkoli od navedenega velja za vas, tablet ne jemljite , ne da bi se prej posvetovali z zdravnikom.
English: In rats and rabbits, there was a dose dependent increase in post implantation loss at exposures greater than or equal to 1.5 times the human exposure (see sections 4.3 and 4.6).
Slovenian: Pri podganah in kuncih so pri izpostavljenosti, ki je bila enaka ali večja od 1,5-kratne izpostavljenosti človeka, ugotovili od odmerka odvisno povečanje izgub zarodkov po ugnezdenju (glejte poglavji 4.3 in 4.6).
English: • if you have serious liver disease
Slovenian: • če imate hudo bolezen ledvic.
English: Gout is a disease of sudden, recurring attacks of very painful inflammation and redness in the joints.
Slovenian: Protin je bolezen, za katero so značilni nenadni, ponavljajoči se napadi zelo bolečega vnetja sklepov in rdečina sklepov.
English: Rheumatoid arthritis is a long term inflammatory disease of the joints.
Slovenian: Revmatoidni artritis je dolgotrajna vnetna bolezen sklepov.
English: If you are currently taking low-dose aspirin to prevent heart attacks or stroke, you should not stop taking aspirin until you talk to your doctor
Slovenian: Če trenutno jemljete majhne odmerke acetilsalicilne kisline za preprečevanje srčne ali možganske kapi, s tem ne prekinite, ne da bi se prej posvetovali s svojim zdravnikom.
English: 30 mg: lactose 1.4 mg 60 mg: lactose 2.8 mg 90 mg: lactose 4.2 mg 120 mg: lactose 5.6 mg
Slovenian: 30 mg: 1,4 mg laktoze 60 mg: 2,8 mg laktoze 90 mg: 4,2 mg laktoze 120 mg: 5,6 mg laktoze
English: If you develop any of these signs you should stop <ARCOXIA> and talk to your doctor immediately:
Slovenian: Če se pri vas pojavi kateri od spodnjih znakov, prenehajte jemati zdravilo <ARCOXIA> in se takoj posvetujte z zdravnikom:
English: What <ARCOXIA> looks like and contents of the pack
Slovenian: Izgled zdravila <ARCOXIA> in vsebina pakiranja
English: (95% CI)
Slovenian: delež† (95 % IZ)
English: The principal metabolite is the 6'-carboxylic acid derivative of etoricoxib formed by further oxidation of the 6'-hydroxymethyl derivative.
Slovenian: Glavni presnovek je 6'-karboksilni derivat etorikoksiba, ki nastane z nadaljnjo oksidacijo 6'-hidroksimetilnega presnovka.
English: COX-2 selective inhibitors are not a substitute for acetylsalicylic acid for prophylaxis of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect.
Slovenian: Selektivni zaviralci COX-2 pri preprečevanju srčno-žilnih tromboemboličnih bolezni ne morejo nadomestiti acetilsalicilne kisline, ker nimajo antiagregacijskega učinka.
English: No dosage adjustment is necessary for patients with creatinine clearance ≥30 ml/min (see section 5.2).
Slovenian: Pri bolnikih s kreatininskim očistkom ≥ 30 ml/min odmerka ni treba prilagajati (glejte poglavje 5.2).
English: • severe or continual stomach pain or your stools become black
Slovenian: • močne ali vztrajne bolečine v trebuhu ali črno blato,
English: It is not known if <ARCOXIA> is excreted in human milk.
Slovenian: Ni znano, če se zdravilo <ARCOXIA> izloča v materino mleko.
English: - In view of the available data, the CHMP considered that the benefit/risk balance for Arcoxia (etoricoxib) 90mg dose in AS indication is positive; however, revisions to the contraindications and warnings sections have been added to the summary of product characteristics and package leaflet in relation to cardiorenal safety.
Slovenian: - Glede na razpoložljive podatke je Odbor za zdravila za uporabo v humani medicini menil, da je razmerje med koristmi in tveganjem za zdravilo Arcoxia (etorikoksib) 90 mg pri zdravljenju ankilozirajočega spondilitisa pozitivno; kljub temu pa so bile v povzetku glavnih značilnostih zdravila in navodilu za uporabo dodane revizije poglavja o kontraindikacijah in opozorilih v zvezi z varnostjo srca in ledvic;
English: As the cardiovascular risks of etoricoxib may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Slovenian: Ker se tveganje za srčno-žilna obolenja pri večjih odmerkih etorikoksiba in daljši izpostavljenosti zdravilu lahko poveča, mora biti zdravljenje čim krajše, dnevni odmerek pa najmanjši, ki je še učinkovit.
English: In vitro studies indicate that CYP2D6, CYP2C9, CYP1A2 and CYP2C19 also can catalyse the main metabolic pathway, but their quantitative roles have not been studied in vivo.
Slovenian: In vitro študije nakazujejo, da lahko tudi CYP2D6, CYP2C9, CYP1A2 in CYP2C19 katalizirajo glavno presnovno pot, vendar njihove kvantitativne vloge niso preučevali in vivo.
English: For information regarding a dose related response for etoricoxib see section 5.1.
Slovenian: Za informacije o odzivu glede na odmerek etorikoksiba glejte poglavje 5.1.
English: Confirmed Peripheral Vascular Events Per-protocol
Slovenian: Potrjeni periferni žilni dogodki