FrancophonIA/ELRC3.0 huggingface dataset:
English: In addition, the MAH should ensure that all users of the spray application of this product are provided with labels for the pressure regulator that inform about the correct pressure and distance in open surgery, a warning card that informs about the correct pressure and distance for the spray application for open surgery and a yellow tag, to be placed on the device air hose, which provides instructions for use.
Slovenian: Zagotoviti mora tudi, da bodo vsi uporabniki tega zdravila v pršilu prejeli oznake za regulator tlaka, ki opozarjajo na pravilen tlak in razdaljo pri odprti kirurški tehniki, opozorilno kartico, ki opozarja na pravilen tlak in razdaljo pršenja pri odprti kirurški tehniki, in rumen kartonček za namestitev na zračno cev pripomočka, ki bo vseboval navodilo za uporabo.
English: • The Committee considered all the cases of air embolism associated with the use of Quixil by spray application that have been reported and concluded that the risk minimisation measures previously implemented were insufficient to mitigate the identified risk of air embolism associated with the use of the Quixil spray application;
Slovenian: • Odbor je proučil vse primere zračne embolije, povezane z napršitvijo zdravila Quixil, o katerih so poročali, in sklenil, da predhodno sprejeti ukrepi za zmanjšanje tveganja ne zadoščajo za odpravo ugotovljenega tveganja za zračno embolijo, povezano z napršitvijo zdravila Quixil.
English: Regarding the clinical use of the product, the CHMP was of the opinion, based on the last case of air embolism that was reported during an endoscopy procedure, where the surgeon has limited visibility of the tissue surface that the use of Quixil by spray application should only be considered if it is possible to accurately judge the spraying distance.
Slovenian: Glede klinične uporabe zdravila je bil odbor CHMP na podlagi zadnjega primera zračne embolije, o katerem so poročali med postopkom endoskopije, pri katerem je bila kirurgova vidljivost površine tkiva omejena, mnenja, da je pršenje zdravila Quixil primerno le v okoliščinah, kadar je mogoče razdaljo pršenja natančno oceniti.
English: Quixil is indicated as supportive treatment in surgery where standard surgical techniques are insufficient, for improvement of haemostasis.
Slovenian: Zdravilo Quixil je indicirano kot podporno zdravljenje v kirurgiji za izboljšanje hemostaze, kadar standardne kirurške tehnike ne zadoščajo.
English: The CHMP reviewed all cases of gas embolism reported with the use of sprayable fibrin sealants.
Slovenian: Odbor je pregledal vse primere plinske embolije, o katerih so poročali ob uporabi fibrinskih tesnilnih sredstev v pršilu.
English: With regard to the efficacy of sprayable fibrin sealants, the CHMP assessed the available information, including data submitted by the MAH.
Slovenian: Odbor CHMP je glede učinkovitosti fibrinskih tesnilnih sredstev v pršilu ocenil razpoložljive informacije, vključno s podatki, ki jih je predložil imetnik dovoljenja za promet z zdravilom.
English: Having considered all the available data, including the MAH responses provided in writing and during oral explanations and the conclusions of the Ad-hoc Expert meeting, the CHMP agreed that the benefitrisk balance of Quixil as supportive treatment in surgery where standard surgical techniques are insufficient, for improvement of haemostasis, remains positive under normal conditions of use, subject to the changes to the product information, (see Annex III), together with the agreed risk minimisation measures (see Annex IV) and the agreed Direct Healthcare Professionals Communication.
Slovenian: Po preučitvi vseh razpoložljivih podatkov, vključno z odgovori imetnika dovoljenja za promet z zdravilom v pisni obliki in v obliki ustnega pojasnila ter zaključki srečanja začasne strokovne skupine je CHMP sklenil, da ostaja razmerje med koristmi in tveganji zdravila Quixil kot podpornega zdravljenja v kirurgiji za izboljšanje hemostaze, kadar standardne kirurške tehnike niso zadostne, ostaja pozitivno v normalnih pogojih uporabe, v skladu s spremembami informacij o zdravilu (glejte Prilogo III), skupaj z odobrenimi ukrepi za zmanjšanje tveganja (glejte Prilogo IV) in z dogovorjenim neposrednim obvestilom za zdravstvene delavce.
English: Moreover, the CHMP concluded that there was insufficient evidence to substantiate a higher risk of air embolus for Quixil (relative to Evicel) because of the different pressure range required for Quixil.
Slovenian: Sklenil je tudi, da dokazi ne zadoščajo za utemeljitev višjega tveganja za zračno embolijo z zdravilom Quixil (v primerjavi z zdravilom Evicel) zaradi drugačnega območja tlaka, ki je potreben za uporabo zdravila Quixil.
English: In conclusion, having considered the available data, the MAH's responses and taking into account the ad-hoc advisory group recommendations, the CHMP identified and agreed upon a number of risk minimisation measures to be implemented by the MAH to reduce the risk of air/gas embolism associated with sprayable fibrin sealants.
Slovenian: V zaključku je odbor CHMP po preučitvi vseh razpoložljivih podatkov, odgovorov imetnika dovoljenja za promet z zdravilom in ob upoštevanju priporočil začasne svetovalne skupine ugotovil ter odobril številne ukrepe za zmanjšanje tveganja, ki jih bo uvedel imetnik dovoljenja za promet z zdravilom za zmanjšanje tveganja za zračno/plinsko embolijo, povezano s fibrinskimi tesnilnimi sredstvi v pršilu.
English: In one of the Quixil cases, the air embolism was caused by using pressurised air to dry the wound area, with a fatal outcome, although no product was administered.
Slovenian: V enem od primerov z zdravilom Quixil je prišlo do zračne embolije s smrtnim izidom zaradi uporabe zraka pod tlakom, ki so ga uporabili za sušenje območja z rano, zdravila pa sploh niso uporabili.
English: The MAH also provided responses to a request from the CHMP to discuss the merits and feasibility of any risk minimisation measures which could be introduced in order to improve the benefit/risk of the Quixil spray application.
Slovenian: Imetnik dovoljenja za promet z zdravilom je na zahtevo odbora CHMP predložil tudi odgovore za razpravo o utemeljenosti in izvedljivosti ukrepov za zmanjšanje tveganja, ki bi jih lahko uvedli za izboljšanje razmerja med koristmi in tveganji napršitve zdravila Quixil.
English: The analysis of the case reports showed that symptomatic air/gas embolism had occurred only when the instructions for use were not followed; in each of the other cases there was a failure to follow at least one of the current guidelines on administration of spray application of Quixil using pressurised gas: 1.
Slovenian: Analiza poročil o primerih je pokazala, da je do simptomatske zračne/plinske embolije prišlo samo, kadar se niso upoštevala navodila za uporabo; v vseh drugih primerih je šlo za neupoštevanje vsaj ene od veljavnih smernic o nanosu pršila zdravila Quixil z uporabo plina pod tlakom: 1. neustrezna razdalja od površine tkiva, 2. previsok tlak, 3. uporaba na odprtih žilah ali v zelo ožiljenih telesnih votlinah, kot je npr. kostni mozeg.
English: The CHMP noted that the difference in composition between Quixil and Evicel results in a higher viscosity for Quixil, which in turn has the consequence that more force is required to deliver spray application of Quixil.
Slovenian: Odbor CHMP je opozoril, da je zaradi razlike v sestavi med zdraviloma Quixil in Evicel zdravilo Quixil bolj viskozno, zaradi česar je za njegovo napršitev potrebna večja sila.
English: The CHMP noted that despite the different recommended pressure regulator settings fibrin sealant spray systems may have similar gas velocity.
Slovenian: Opozoril je tudi, da je lahko hitrost plina v sistemih fibrinskih tesnilnih sredstev v pršilu kljub priporočenim različnim nastavitvam regulatorja tlaka podobno.
English: If spraying is required, a pressure regulator has to be used with pressurized CO2 or compressed air. From 2008 until May 2012, four cases of life-threatening air embolism were reported for the spray application of Quixil (of which one had a fatal outcome but without any product being administered).
Slovenian: Od leta 2008 do maja 2012 so poročali o štirih primerih življenjsko nevarne zračne embolije ob napršitvi zdravila Quixil (od katerih je ena imela smrtni izid, pri čemer zdravilo sploh ni bilo uporabljeno).
English: • The Committee, as a consequence, concluded that the benefit-risk balance of Quixil as supportive treatment in surgery where standard surgical techniques are insufficient, for improvement of haemostasis, is positive under normal conditions of use, subject to the agreed risk minimisation measures, including changes to the product information.
Slovenian: • Odbor je posledično sklenil, da je razmerje med koristmi in tveganji zdravila Quixil kot podpornega zdravljenja v kirurgiji za izboljšanje hemostaze, kadar standardne kirurške tehnike niso zadostne, pozitivno v normalnih pogojih uporabe, v skladu z odobrenimi ukrepi za zmanjšanje tveganja, vključno s spremembami informacij o zdravilu, je odbor CHMP priporočil spremembo pogojev dovoljenj za promet z zdravilom, navedenimi v Prilogi I, v skladu s spremembami povzetka glavnih značilnosti zdravila in navodila za uporabo, določenih v Prilogi III, in pod pogoji, določenimi v Prilogi IV.
English: • It is important to follow the advice given in section 3 How to take Tredaptive.
Slovenian: • Pomembno je, da upoštevate navodila v poglavju 3 Kako jemati zdravilo Tredaptive.
English: Tredaptive with food, drink and alcohol
Slovenian: Zdravilo Tredaptive skupaj s hrano, pijačo in alkoholom
English: Your doctor will decide if Tredaptive is right for you.
Slovenian: Zdravnik bo odločil, ali je zdravilo Tredaptive primerno za vas.
English: Daily doses greater than 2000 mg/40 mg have not been studied and therefore are not recommended.
Slovenian: Dnevni odmerki, večji od 2.000 mg/40 mg, niso raziskani in zato niso priporočljivi.
English: Efficacy and safety of Tredaptive in combination with simvastatin > 40 mg were not included in this study.
Slovenian: Učinkovitosti in varnosti zdravila Tredaptive v kombinaciji s simvastatinom > 40 mg v tej študiji niso preučevali.
English: Other medicines and Tredaptive
Slovenian: Druga zdravila in zdravilo Tredaptive
English: MARKETING AUTHORISATION NUMBER(S) EU/1/08/459/012
Slovenian: ŠTEVILKA(E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/08/459/012
English: • medicines used to lower blood pressure.
Slovenian: • zdravila za zniževanje krvnega tlaka.
English: Safety and effectiveness of Tredaptive in paediatric patients under the age of 18 years have not been established.
Slovenian: Varnost in učinkovitost zdravila Tredaptive pri pediatričnih bolnikih, mlajših od 18 let, nista bili dokazani.
English: Therefore, Tredaptive should not be used during pregnancy unless clearly necessary.
Slovenian: Zato se zdravila Tredaptive ne sme uporabljati pri nosečnicah, razen če to ni nujno.
English: INFORMATION IN BRAILLE Tredaptive
Slovenian: PODATKI V BRAILLOVI PISAVI Tredaptive
English: • Take Tredaptive with food.
Slovenian: • Vzemite ga s hrano.
English: Weeks on Treatment
Slovenian: Tedni zdravljenja
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy should be made taking into account the benefit of breast-feeding to the child and the benefit of Tredaptive to the woman.
Slovenian: Odločiti se je treba med nadaljevanjem/prenehanjem dojenja in nadaljevanjem/prenehanjem zdravljenja, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja z zdravilom Tredaptive za mater.
English: Side effects of Tredaptive are:
Slovenian: Neželeni učinki zdravila Tredaptive so:
English: It is not known if Tredaptive will harm your unborn baby.
Slovenian: Ni znano, ali zdravilo Tredaptive škoduje nerojenemu otroku.
English: Therefore, Tredaptive should not be used in children and adolescents under 18 years of age.
Slovenian: Zato se zdravila Tredaptive ne sme uporabljati pri otrocih in mladostnikih, mlajših od 18 let.
English: In particular, tell your doctor or pharmacist if you are taking any of the following:
Slovenian: Še zlasti morate svojemu zdravniku ali farmacevtu povedati, če jemljete katero od naslednjih zdravil:
English: Tredaptive is used in addition to diet
Slovenian: Zdravilo Tredaptive se uporablja poleg diete za:
English: If you forget to take Tredaptive
Slovenian: Če ste pozabili vzeti zdravilo Tredaptive
English: Patients with hepatic or renal insufficiency
Slovenian: Bolniki z jetrno ali ledvično insuficienco
English: The frequencies of adverse reactions are ranked according to the following: Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to < 1/100), Rare (≥ 1/10,000 to < 1/1,000), Very rare (< 1/10,000), Not known (cannot be estimated from the available data).
Slovenian: Neželeni učinki so po pogostnosti razvrščeni takole: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000),
English: What Tredaptive is and what it is used for What you need to know before you take Tredaptive How to take Tredaptive
Slovenian: Kaj je zdravilo Tredaptive in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Tredaptive Kako jemati zdravilo Tredaptive
English: If you get dizzy, you should avoid driving or operating machines after taking Tredaptive.
Slovenian: Če postanete omotični, se med jemanjem zdravila Tredaptive izogibajte vožnji ali upravljanju strojev.
English: Tredaptive is used in addition to diet and exercise in adult patients with primary hypercholesterolaemia or mixed dyslipidaemia:
Slovenian: Zdravilo Tredaptive se uporablja poleg diete in telesne vadbe pri odraslih bolnikih s primarno hiperholesterolemijo ali z mešano dislipidemijo:
English: Tredaptive should be used with caution in patients who consume substantial quantities of alcohol and/or have a past history of liver disease.
Slovenian: Zdravilo Tredaptive morate previdno uporabljati pri bolnikih, ki uživajo velike količine alkohola in/ali imajo anamnezo bolezni jeter.
English: In a pool of four active- or placebo-controlled clinical trials (N=4,747, n=2,548 taking Tredaptive), flushing was reported in 12.3 % of patients taking Tredaptive.
Slovenian: V štirih z učinkovino ali s placebom kontroliranih kliničnih preskušanjih (N=4.747, n = 2.548 jih je jemalo zdravilo Tredaptive) so o zardevanju poročali pri 12,3 % bolnikov,
English: • Take Tredaptive once a day, in the evening or at bedtime.
Slovenian: • Zdravilo Tredaptive vzemite enkrat na dan, zvečer ali pred spanjem.
English: The effect on lipids was similar whether Tredaptive was given as monotherapy or was added to ongoing statin therapy with or without ezetimibe.
Slovenian: Učinek na lipide je bil podoben, naj je bilo zdravilo Tredaptive uporabljeno v monoterapiji ali dodano že vpeljanemu statinskemu zdravljenju, z ezetimibom ali brez njega.
English: Clinically important elevations of CK (≥ 10 X ULN) were seen in 0.3 % of the patients treated with Tredaptive with or without a statin (see section 4.4).
Slovenian: Klinično pomembno zvišanje CK (≥ 10 x ZNM) so opazili pri 0,3 % bolnikov, ki so dobivali zdravilo Tredaptive s statinom ali brez njega (glejte poglavje 4.4).
English: ▲ Tredaptive  nicotinic acid (laropiprant withdrawn at Week 21)
Slovenian: ▲ Tredaptive  nikotinska kislina (ukinitev laropipranta v 21. tednu)
English: If you stop taking Tredaptive Do not stop taking Tredaptive without talking to your doctor.
Slovenian: Ne nehajte jemati zdravila Tredaptive, ne da bi se posvetovali s svojim zdravnikom.
English: Flushing is the most common adverse reaction of Tredaptive.
Slovenian: Zardevanje je najpogostejši neželeni učinek zdravila Tredaptive.
English: Marked and persistent increases of serum transaminases have been reported infrequently (see section 4.4).
Slovenian: Redko so poročali o izrazitem in stalnem porastu serumskih transaminaz (glejte poglavje 4.4).
English: In an interim analysis of an ongoing clinical outcome study, an independent safety monitoring committee identified a higher than expected incidence of myopathy in Chinese patients taking Tredaptive and simvastatin 40 mg.
Slovenian: V vmesni analizi trenutno potekajoče preživetvene študije je neodvisen odbor za spremljanje varnosti odkril višjo pojavnost miopatije pri kitajskih bolnikih, ki so jemali zdravilo Tredaptive in simvastatin
English: Tredaptive is not recommended in pregnancy unless clearly necessary.
Slovenian: Nosečnost in dojenje Zdravila Tredaptive v nosečnosti ne priporočamo, razen če je nujno potrebno.
English: However, if you do not take Tredaptive for 7 or more days in a row, talk to your doctor before restarting Tredaptive.
Slovenian: Če pa se zgodi, da zdravila Tredaptive niste vzeli 7 ali več dni zapored, se pred ponovnim začetkom jemanja posvetujte z zdravnikom.
English: Tredaptive contains a sugar called lactose.
Slovenian: Tredaptive vsebuje sladkor, imenovan laktoza.
English: Like other nicotinic acid medicinal products, Tredaptive is contraindicated in patients with significant or unexplained hepatic dysfunction.
Slovenian: Tako kot druga zdravila z nikotinsko kislino je tudi zdravilo Tredaptive kontraindicirano pri bolnikih s pomembno ali nepojasnjeno motnjo delovanja jeter.
English: Tredaptive has not been studied in children and adolescents who are under 18 years of age.
Slovenian: Zdravilo Tredaptive ni raziskano pri otrocih in mladostnikih, mlajših od 18 let.
English: Should an increase in alanine aminotransferase (ALT) or aspartate aminotransferase (AST) of ≥ 3 X ULN persist, reduction of dose or withdrawal of Tredaptive is recommended.
Slovenian: Če zvišanje vrednosti alanin aminotransferaze (ALT) ali aspartat aminotransferaze (AST) na ≥ 3 x ZMN (zgornja meja normalne vrednosti) vztraja, je priporočljivo zmanjšati odmerek zdravila Tredaptive ali pa zdravilo Tredaptive prenehati uporabljati.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Tredaptive in paediatric patients from 7-18 years old in heterozygous familial hypercholesterolaemia (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila obvezo za predložitev rezultatov študij z zdravilom Tredaptive pri pediatričnih bolnikih s heterozigotno družinsko hiperholesterolemijo, starih od 7-18 let (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Tredaptive contains nicotinic acid, which at therapeutic doses is a lipid-modifying agent, and laropiprant, a potent, selective antagonist of the prostaglandin D2 (PGD2) receptor subtype 1 (DP1).
Slovenian: Zdravilo Tredaptive vsebuje nikotinsko kislino, ki v terapevtskih odmerkih vpliva na lipide, in laropiprant, močan, selektiven antagonist receptorja prostaglandina D2 (PGD2) podvrste 1 (DP1).
English: Each modified-release tablet contains 128.4 mg of lactose monohydrate.
Slovenian: Ena tableta s prirejenim sproščanjem vsebuje 128,4 mg laktoze monohidrata.
English: If Tredaptive is missed for less than 7 consecutive days, patients can resume therapy at the last administered dose.
Slovenian: Če bolnik zdravila Tredaptive ne vzame manj kot 7 dni zapored, ga lahko znova začne jemati v nazadnje uporabljanem odmerku.
English: Nicotinic acid causes a relative shift in the distribution of LDL subclasses from small, dense (most atherogenic) LDL particles to larger LDL particles.
Slovenian: Nikotinska kislina povzroči relativen premik porazdelitve podskupin LDL od majhnih, gostih (najbolj aterogenih) delcev LDL proti večjim delcem LDL.
English: Supplements containing nicotinic acid: Vitamins or other nutritional supplements containing (≥ 50 mg/day) of nicotinic acid (or nicotinamide) have not been studied with Tredaptive.
Slovenian: Dodatki, ki vsebujejo nikotinsko kislino: Uporaba vitaminov in drugih prehranskih dopolnil, ki vsebujejo (≥ 50 mg/dan) nikotinsko kislino (ali nikotinamid) hkrati z zdravilom Tredaptive ni raziskana.
English: Also tell your doctor if you are taking simvastatin (a statin) or a medicine containing simvastatin and are Chinese.
Slovenian: Zdravniku povejte tudi, če jemljete simvastatin (statin) ali zdravilo, ki vsebuje simvastatin, in ste
English: Tredaptive is indicated for the treatment of dyslipidaemia, particularly in adult patients with combined mixed dyslipidaemia (characterised by elevated levels of LDL-cholesterol and triglycerides and low HDL-cholesterol) and in adult patients with primary hypercholesterolaemia (heterozygous familial and non-familial).
Slovenian: Zdravilo Tredaptive je indicirano za zdravljenje dislipidemije, zlasti pri odraslih bolnikih s kombinirano mešano dislipidemijo (za katero so značilni zvišani LDL holesterol in trigliceridi in nizek HDL holesterol), in pri odraslih bolnikih s primarno hiperholesterolemijo (heterozigotno družinsko in nedružinsko).
English: • Taking aspirin before you take Tredaptive does not reduce your flushing more than taking Tredaptive alone.
Slovenian: • Jemanje acetilsalicilne kisline pred zaužitjem zdravila Tredaptive ne bo bolj zmanjšalo zardevanja, kot če vzamete samo zdravilo Tredaptive.
English: The tablets should be taken whole, with food, in the evening or at bedtime.
Slovenian: Tablete Tredaptive mora bolnik vzeti cele, s hrano, zvečer ali pred spanjem.
English: It is not known if Tredaptive will pass into your breast milk.
Slovenian: Ni znano, ali zdravilo Tredaptive prehaja v materino mleko.
English: Warnings and precautions Tell your doctor about all of your medical conditions.
Slovenian: Zdravniku morate povedati za vse svoje zdravstvene težave.
English: The Coronary Drug Project, a five year study completed in 1975, showed that nicotinic acid had a statistically significant benefit in decreasing nonfatal, recurrent myocardial infarctions (MI) in men 30 to 64 years old with a history of MI.
Slovenian: Drug Project, ki se je končala leta 1975, je pokazala, da nikotinska kislina statistično značilno pripomore k zmanjšanju števila neusodnih ponovnih miokardnih infarktov (MI) pri moških od 30. do 64. leta starosti z anamnezo MI.
English: Other abnormal laboratory values reported were elevations in LDH, fasting glucose, uric acid, total bilirubin, and amylase, and reductions in phosphorus and platelet counts (see section 4.4).
Slovenian: Druge nenormalne laboratorijske vrednosti, o katerih so poročali, so bile zvišanje LDH, glukoze na tešče, sečne kisline, celotnega bilirubina in amilaze ter znižanje fosforja in števila trombocitov (glejte poglavje 4.4).
English: • After 4 weeks, your doctor may raise your dose to two tablets a day.
Slovenian: Po 4 tednih vam zdravnik lahko odmerek poveča na dve tableti zdravila Tredaptive na dan.
English: Additional explanations that do not invoke plasma FFA reduction as the central driver of lipid profile modification include nicotinic acid-mediated inhibition of de novo lipogenesis or esterification of fatty acids into TG in the liver.
Slovenian: Dodatne razlage, ki ne zajemajo znižanja PMK v palzmi kot glavnega gonila sprememb sestave lipidov, vključujejo z nikotinsko kislino posredovano zavrtje de novo lipogeneze ali esterifikacijo maščobnih kislin v trigliceride v jetrih.
English: The glycine conjugation pathway is not saturated across the clinically relevant dose range, based on the dose-proportional increase in the plasma concentrations of NUA from 1,000 mg to 2,000 mg.
Slovenian: Pot konjugacije z glicinom pa se v celotnem razponu klinično pomembnih odmerkov ne nasiti, če presojamo na podlagi odmerku sorazmernega porasta koncentracije nikotinurične kisline v plazmi od odmerka 1.000 mg do 2.000 mg.
English: • Your doctor should do a blood test before you start taking Tredaptive to check how well your liver is working.
Slovenian: • Pred začetkom uporabe zdravila Tredaptive vas mora zdravnik poslati na preiskavo krvi, da bo preveril delovanje vaših jeter.
English: Do not take Tredaptive if any of the above apply to you.
Slovenian: Ne vzemite zdravila Tredaptive, če kaj od naštetega velja za vas.