FrancophonIA/ELRC3.0 huggingface dataset:
English: Such signs are listed under “Serious side effects” in section 4.
Croatian: Takvi znakovi navedeni su u odlomku ‘Ozbiljne nuspojave' u dijelu 4.
English: A: Prepare A1.
Croatian: A: Pripremite se A1. Prikupite pribor
English: The needle is inside.
Croatian: Unutar njega nalazi se igla.
English: - if you are allergic to dupilumab or any of the other ingredients of this medicine (listed in section 6).
Croatian: - ako ste alergični na dupilumab ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: Most patients with conjunctivitis recovered or were recovering during the treatment period.
Croatian: Većina bolesnika s konjunktivitisom oporavila se ili se oporavljala tijekom razdoblja liječenja.
English: The effects of this medicine in pregnant women are not known; therefore it is preferable to avoid the use of Dupixent in pregnancy unless your doctor advises to use it.
Croatian: Nisu poznati učinci ovog lijeka u trudnica; stoga je poželjno izbjegavati primjenu lijeka Dupixent tijekom trudnoće, osim ako Vam liječnik to ne savjetuje.
English: Other medicines and Dupixent
Croatian: Drugi lijekovi i Dupixent
English: Efficacy and safety in this age group were similar to the overall study population.
Croatian: Djelotvornost i sigurnost u toj dobnoj skupini bile su slične onima u cjelokupnoj ispitivanoj populaciji.
English: ≥ 2 points on a 0-4 IGA scale.
Croatian: postignutim smanjenjem za ≥ 2 boda na IGA ljestvici od 0 do 4 boda.
English: What Dupixent is and what it is used for
Croatian: Što je Dupixent i za što se koristi
English: In addition, Dupixent helps improve your sleep disturbance and overall quality of life.
Croatian: Osim toga, Dupixent pridonosi poboljšanju sna i sveukupne kvalitete života.
English: Regeneron Ireland Unlimited Company (U.C.)
Croatian: Regeneron Ireland Unlimited Company (U.C.) Ballycummin
English: Similar results were observed in VENTURE.
Croatian: Slični su rezultati opaženi i u ispitivanju VENTURE.
English: Dupilumab is intended for long-term treatment.
Croatian: Dupilumab je namijenjen za dugoročno liječenje.
English: Do not recycle the container.
Croatian: Spremnik se ne smije reciklirati.
English: Step 2: Prepare
Croatian: 2. korak: Pripremite se
English: • fainting, dizziness, feeling lightheaded (low blood pressure)
Croatian: • nesvjesticu, omaglicu, ošamućenost (nizak krvni tlak)
English: • The window will start to turn yellow.
Croatian: • Prozorčić će početi poprimati žutu boju.
English: Push the plunger rod down slowly and steadily as far as it will go until the syringe is empty.
Croatian: Polako i ravnomjerno pritišćite potisnik klipa prema dolje koliko god ide, sve dok štrcaljka ne bude prazna.
English: 16-Week Monotherapy Studies (SOLO 1 and SOLO 2)
Croatian: 16-tjedna ispitivanja monoterapije (SOLO 1 i SOLO 2)
English: This usually, but not always, happens in people who also take a steroid medicine which is being stopped or for which the dose is being lowered.
Croatian: To se stanje obično, ali ne i uvijek, javlja u ljudi koji istodobno uzimaju i steroidni lijek čija se primjena u tom trenutku prekida ili čija se doza u tom trenutku smanjuje.
English: Stop using Dupixent and tell your doctor or get medical help immediately if you notice any signs of an allergic reaction.
Croatian: Prestanite primjenjivati Dupixent i odmah potražite liječničku pomoć ako primijetite bilo kakve znakove alergijske reakcije.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of repeated dose toxicity (including safety pharmacology endpoints) and toxicity to reproduction and development.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja toksičnosti ponovljenih doza (uključujući farmakološke mjere ishoda za sigurnost) te reproduktivne i razvojne toksičnosti.
English: Although no differences in safety or efficacy were observed between older and younger adult atopic dermatitis patients, the number of patients aged 65 and over is not sufficient to determine whether they respond differently from younger patients.
Croatian: Iako nisu opažene razlike u sigurnosti ili djelotvornosti između starijih i mlađih odraslih bolesnika s atopijskim dermatitisom, broj bolesnika u dobi od 65 ili više godina nije bio dovoljno velik da bi se utvrdilo odgovaraju li ti bolesnici drugačije od mlađih.
English: If the window does not turn completely yellow, remove the pen and call your healthcare provider.
Croatian: Ako prozorčić nije potpuno požutio, uklonite brizgalicu i nazovite svog zdravstvenog radnika.
English: Life Quality Index (CDLQI) was 13.6.
Croatian: Children dermatology life quality index,CDLQI) bila je 13,6.
English: Less than 0.4 % of patients exhibited high titer ADA responses associated with reduced exposure and efficacy.
Croatian: Manje od 0,4% bolesnika odgovorilo je visokim titrom protutijela na lijek, povezanim sa smanjenom izloženošću i djelotvornošću.
English: The need for continued therapy should be considered at least on an annual basis as determined by physician assessment of the patient's level of asthma control.
Croatian: Potrebu za nastavkom liječenja treba razmotriti najmanje jednom godišnje na temelju liječnikove ocjene bolesnikove razine kontrole astme.
English: What Dupixent looks like and contents of the pack
Croatian: Kako Dupixent izgleda i sadržaj pakiranja
English: The mutagenic potential of dupilumab has not been evaluated; however monoclonal antibodies are not expected to alter DNA or chromosomes.
Croatian: Nije se ocjenjivao mutageni potencijal dupilumaba; međutim, ne očekuje se da će monoklonska protutijela izmijeniti DNK ili kromosome.
English: For information on live vaccines see section 4.4.
Croatian: Za informacije o živim cjepivima vidjeti dio 4.4.
English: Thereafter, resume dosing at the regular scheduled time.
Croatian: Nakon toga treba nastaviti s primjenom prema uobičajenom rasporedu.
English: Industriepark Hoechst 65926 FRANKFURT AM MAIN GERMANY
Croatian: Industriepark Hoechst 65926 FRANKFURT AM MAIN
English: Pinch a fold of skin at the injection site, as shown in the picture.
Croatian: Uhvatite nabor kože na mjestu injiciranja, kako je prikazano na slici.
English: These events usually, but not always, may be associated with the reduction of oral corticosteroid therapy.
Croatian: Ti su događaji obično, ali ne i uvijek, povezani sa smanjenjem doze oralnih kortikosteroida.
English: Dupilumab should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Croatian: Dupilumab se smije primjenjivati tijekom trudnoće samo ako moguća korist od liječenja opravdava mogući rizik za plod.
English: In CHRONOS, efficacy was also evaluated at week 52.
Croatian: U ispitivanju CHRONOS djelotvornost se ocjenjivala i u 52. tjednu.
English: If you develop an allergic reaction, stop using Dupixent and talk to your doctor right away.
Croatian: Ako razvijete alergijsku reakciju, prestanite primjenjivati Dupixent i odmah se obratite svom liječniku.
English: • general ill feeling
Croatian: • opće loše osjećanje
English: Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.
Croatian: Mogu se koristiti topikalni inhibitori kalcineurina, ali njih treba čuvati isključivo za problematična područja, kao što su lice, vrat te intertriginozna i genitalna područja.
English: Parasitic (intestinal parasites) infection
Croatian: Parazitske infekcije (crijevni paraziti)
English: • Check that you have the correct product and dose.
Croatian: • Provjerite imate li točan lijek i točnu dozu.
English: • Check that the entire window has turned to yellow.
Croatian: • Provjerite je li cijeli prozorčić požutio.
English: Steroid reductions should be accomplished gradually (see section 4.4).
Croatian: Dozu steroida treba smanjivati postupno (vidjeti dio 4.4).
English: Patients with known helminth infections were excluded from participation in clinical studies.
Croatian: Bolesnici s poznatim infekcijama helmintima nisu bili uključeni u klinička ispitivanja.
English: The data gathered from this study did not indicate clinically relevant effects of dupilumab on CYP1A2, CYP3A, CYP2C19, CYP2D6, or CYP2C9 activity.
Croatian: Podaci prikupljeni u tom ispitivanju nisu ukazivali na klinički važne učinke dupilumaba na aktivnost CYP1A2, CYP3A, CYP2C19, CYP2D6 ni
English: - if you think you may be allergic, or you are not sure, ask your doctor, pharmacist or nurse for advice before using Dupixent.
Croatian: - ako mislite da biste mogli biti alergični ili niste sigurni, obratite se svom liječniku, ljekarniku ili medicinskoj sestri za savjet prije nego što primijenite Dupixent
English: Talk to your doctor if you have any new or worsening eye problems, including eye pain or changes in vision.
Croatian: Razgovarajte sa svojim liječnikom ako se pojave nove ili pogoršaju postojeće očne tegobe, uključujući bol u oku ili promjene vida.
English: Conjunctivitis and related events
Croatian: Konjunktivitis i povezani događaji
English: Some patients with initial partial response may subsequently improve with continued treatment beyond 16 weeks.
Croatian: Nekim bolesnicima koji na početku ostvare djelomičan odgovor stanje se može naknadno poboljšati nastavkom liječenja i nakon 16 tjedana.
English: EXP Date of removal from the refrigerator: / / /
Croatian: Datum vađenja iz hladnjaka: / / /
English: • cold sores (on lips and skin)
Croatian: • infekcija oka • herpes (na usnama i koži)
English: • swelling of the face, mouth, and tongue
Croatian: • tegobe s disanjem • oticanje lica, usta i jezika
English: • a puncture-resistant container* (See Step D)
Croatian: • neprobojan spremnik* (pogledajte korak D)
English: Endpoints were assessed at weeks 51 or 52.
Croatian: Mjere ishoda ocjenjivale su se u 51. ili 52. tjednu.
English: There are limited amount of data from the use of dupilumab in pregnant women.
Croatian: Postoje ograničeni podaci o primjeni dupilumaba u trudnica.
English: IL-4 and IL-13 are major drivers of human type 2 inflammatory disease, such as atopic dermatitis and asthma.
Croatian: IL-4 i IL-13 glavni su pokretači upalne bolesti tipa 2, kao što su atopijski dermatitis i astma.
English: Do not use this medicine after the expiry date which is stated on the label and carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnici i kutiji iza oznake „EXP”.
English: Do not rub your skin after the injection.
Croatian: Nemojte trljati kožu nakon injekcije.
English: You must look out for signs of these conditions (i.e. breathing problems, swelling of the face, mouth, and tongue, fainting, dizziness, feeling lightheaded (low blood pressure), fever, general ill feeling, swollen lymph nodes, hives, itching, joint pain, skin rash) while you are taking Dupixent.
Croatian: Morate pripaziti na znakove tih stanja (tj. tegobe s disanjem, oticanje lica, usta i jezika, nesvjesticu, omaglicu, ošamućenost [nizak krvni tlak], vrućicu, opće loše osjećanje, otečene limfne čvorove, koprivnjaču, svrbež, bol u zglobovima, kožni osip) dok primjenjujete Dupixent.
English: Press down
Croatian: Pritisnite prema dolje
English: If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.
Croatian: Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego primijenite ovaj lijek.
English: How much Dupixent is given and for how long
Croatian: Koliko se lijeka Dupixent primjenjuje i koliko dugo
English: At Week 12
Croatian: U 12. tjednu
English: Look at the label
Croatian: A2. Pogledajte naljepnicu
English: After removal from the refrigerator, Dupixent must be used within 14 days or discarded.
Croatian: Nakon vađenja iz hladnjaka, Dupixent se mora upotrijebiti unutar 14 dana ili baciti.
English: < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000).
Croatian: (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko
English: - The active substance is dupilumab.
Croatian: - Djelatna tvar je dupilumab.
English: Clinical efficacy and safety in asthma
Croatian: Klinička djelotvornost i sigurnost kod astme
English: If you use more Dupixent than you should
Croatian: Ako primijenite više lijeka Dupixent nego što ste trebali
English: Eye problems (if you have atopic dermatitis)
Croatian: Tegobe s očima (ako imate atopijski dermatitis)
English: Do not dispose of (throw away) pre-filled pens (needle inside), and yellow caps in your household trash.
Croatian: Nemojte odlagati (bacati) brizgalice (u kojima se nalazi igla) i žute zatvarače u kućni otpad.
English: Check with your doctor if you have diarrhea, gas, upset stomach, greasy stools, and dehydration which could be a sign of a parasitic infection.
Croatian: Provjerite sa svojim liječnikom ako imate proljev, vjetrove, želučane tegobe, masne stolice i dehidraciju, jer to bi mogli biti znakovi parazitske infekcije.
English: There is no specific treatment for dupilumab overdose.
Croatian: Ne postoji specifično liječenje za predoziranje dupilumabom.
English: If a systemic hypersensitivity reaction (immediate or delayed) occurs, administration of dupilumab should be discontinued immediately and appropriate therapy initiated.
Croatian: Ako dođe do sistemskih reakcija preosjetljivosti (trenutačnih ili odgođenih), treba odmah prekinuti primjenu dupilumaba i uvesti odgovarajuću terapiju.
English: Live and live attenuated vaccines should not be given concurrently with dupilumab as clinical safety and efficacy has not been established.
Croatian: Živa i živa atenuirana cjepiva ne smiju se primjenjivati istodobno s liječenjem dupilumabom jer nisu ustanovljene klinička sigurnost i djelotvornost.
English: Dupilumab is expected to degrade to small peptides and individual amino acids.
Croatian: Očekuje se da će se dupilumab razgraditi u malene peptide i pojedinačne aminokiseline.
English: Dupixent may be used with eczema medicines that you apply to the skin or it may be used on its own.
Croatian: Dupixent se može koristiti zajedno s lijekovima za ekcem koji se nanose na kožu ili se može primjenjivati samostalno.
English: Week 52 (FAS Week 52)b
Croatian: 52. tjedan (FAS, 52. tjedan)b
English: Adolescents
Croatian: Adolescenti
English: SANOFI WINTHROP INDUSTRIE 1051 Boulevard Industriel, 76580 LE TRAIT, FRANCE
Croatian: SANOFI WINTHROP INDUSTRIE 1051 Boulevard Industriel, 76580 LE TRAIT, Francuska
English: Week 16 (FAS)b
Croatian: 16. tjedan (FAS)b
English: • a puncture-resistant container* (See Step 12)
Croatian: • neprobojan spremnik* (pogledajte 12. korak)
English: The most common adverse reactions were injection site reactions, conjunctivitis, blepharitis, and oral herpes.
Croatian: Najčešće nuspojave bile su reakcije na mjestu injiciranja, konjunktivitis, blefaritis i oralni herpes.
English: SOLO 1 at Week 16
Croatian: SOLO 1 u 16. tjednu
English: Dupilumab elimination is mediated by parallel linear and nonlinear pathways.
Croatian: U eliminaciji dupilumaba posreduju paralelni linearni i nelinearni putovi.
English: Efficacy data from this study suggests that clinical benefit provided at week 16 was sustained through week 52.
Croatian: Podaci o učinkovitosti iz tog ispitivanja ukazuju da je klinička korist ostvarena u 16. tjednu zadržana i do 52. tjedna.
English: At higher concentrations, dupilumab elimination is primarily through a non-saturable proteolytic pathway, while at lower concentrations, the non-linear saturable IL-4R α target-mediated elimination predominates.
Croatian: Pri višim se koncentracijama eliminacija dupilumaba odvija prvenstveno nesaturabilnim, proteolitičkim putem, dok pri nižim koncentracijama prevladava nelinearna, saturabilna eliminacija posredovana ciljnim mjestom IL-4R α.
English: The safety profile observed was similar to that seen in adults.
Croatian: Opažen sigurnosni profil bio je sličan onom primijećenom u odraslih.
English: Do not touch the injection site again or blow on it before the injection.
Croatian: Nemojte ponovno dodirivati mjesto injiciranja niti puhati u njega prije primjene lijeka.
English: Time out of refrigeration should not exceed a maximum of 14 days at temperature below 25 °C.
Croatian: Vrijeme čuvanja izvan hladnjaka ne smije biti dulje od 14 dana na temperaturi ispod 25°C.
English: Dupixent may weaken your resistance to infections caused by parasites.
Croatian: Dupixent može oslabiti otpornost na infekcije koje uzrokuju paraziti.
English: If a dose is missed, administer the dose as soon as possible.
Croatian: Ako bolesnik propusti primiti dozu lijeka, treba je primijeniti što je prije moguće.
English: No reduction or any increase in OCS dose, or dropped out of study
Croatian: Bez smanjenja ili bilo kakvog povećanja doze
English: Oral Corticosteroid Reduction Study (VENTURE)
Croatian: Ispitivanje smanjenja doze oralnih kortikosteroida (VENTURE)
English: Patients continued to receive their existing asthma medicine during the study; however their OCS dose was reduced every 4 weeks during the OCS reduction phase (week 4-20), as long as asthma control was maintained.
Croatian: Bolesnici su tijekom ispitivanja nastavili primjenjivati dotadašnje lijekove za astmu; međutim, doza OKS-a smanjivala im se svaka 4 tjedna tijekom faze smanjivanja doze OKS-a (od 4. do 20. tjedna), pod uvjetom da je kontrola astme bila održana.
English: If you already have a parasitic infection it should be treated before you start treatment with Dupixent.
Croatian: Ako već imate parazitsku infekciju, potrebno ju je liječiti prije nego što započnete liječenje lijekom Dupixent.
English: You and your doctor or nurse should decide if you should inject Dupixent yourself.
Croatian: Vi i Vaš liječnik ili medicinska sestra odlučit ćete o tomu hoćete li Dupixent sebi injicirati sami.
English: • To help prevent accidental needle injury, each pre-filled syringe has a needle shield that is automatically activated to cover the needle after you have given your injection.
Croatian: • Radi sprječavanja nehotičnih ozljeda iglom, svaka napunjena štrcaljka ima zaštitni pokrov igle koji se nakon injekcije automatski aktivira i prekriva iglu.
English: Overall, 92.0% of patients had at least one co-morbid allergic condition; 65.6% had allergic rhinitis, 53.6% had asthma, and 60.8% had food allergies.
Croatian: Sveukupno je 92,0% bolesnika imalo barem jedno komorbiditetno stanje povezano s alergijom, 65,6% je imalo alergijski rinitis, 53,6% je imalo astmu, a 60,8% alergije na hranu.
English: However, there were only 61 patients over 65 years of age included in this analysis.
Croatian: Međutim, u tu je analizu bio uključen svega 61 bolesnik stariji od
English: Body Weight of Patient
Croatian: Tjelesna težina bolesnika
English: These markers were near maximal suppression after 2 weeks of treatment, except for IgE which declined more slowly.
Croatian: Supresija tih bioloških biljega bila je blizu maksimalne vrijednosti nakon 2 tjedna liječenja, osim u slučaju IgE-a, čija je vrijednost opadala nešto sporije.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with dupilumab in one or more subset of the paediatric population in atopic dermatitis and asthma (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka Dupixent u jednoj ili više podskupina pedijatrijske populacije u liječenju atopijskog dermatitisa i astme (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: A total of 305 patients were treated with dupilumab for at least 1 year.
Croatian: Ukupno je 305 bolesnika bilo liječeno dupilumabom tijekom najmanje godinu dana.
English: Remove the syringe from the carton by holding the middle of the syringe body.
Croatian: Izvadite štrcaljku iz kutije držeći je za srednji dio tijela.
English: Initial Dose
Croatian: Početna doza
English: The responder rate was defined as an improvement in score of 0.5 or more (scale range 0-6 for ACQ-5 and 1-7 for AQLQ(S)).
Croatian: Odgovor se definirao kao poboljšanje rezultata za 0,5 ili više bodova (ACQ-5 ima raspon od 0 do 6 bodova, a AQLQ(S) od 1 do 7 bodova).
English: If dupilumab treatment interruption becomes necessary, patients can still be successfully re-treated.
Croatian: Ako prekid liječenja dupilumabom postane nužan, bolesnici se i dalje mogu naknadno uspješno liječiti ponovnim uvođenjem dupilumaba.
English: If the carton needs to be removed permanently from refrigerator, the date of removal may be recorded on the outer carton.
Croatian: Ako se kutija mora trajno izvaditi iz hladnjaka, datum vađenja iz hladnjaka može se zapisati na kutiji.
English: • Ask your healthcare professional to show you the right way to use the syringe before you inject for the first time.
Croatian: • Zamolite zdravstvenog radnika da Vam pokaže kako pravilno koristiti štrcaljku prije nego prvi put primijenite Dupixent.
English: Physicians should be alert to vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/or neuropathy presenting in their patients with eosinophilia.
Croatian: Liječnici trebaju pripaziti na moguću pojavu vaskulitičnog osipa, pogoršanje plućnih simptoma, srčane komplikacije i/ili neuropatiju u bolesnika s eozinofilijom.
English: An evaluation of the available evidence related to IL-4Rα inhibition and animal toxicology data with surrogate antibodies does not suggest an increased carcinogenic potential for dupilumab.
Croatian: Ocjena dostupnih dokaza povezanih s inhibicijom IL-4Rα i podataka iz toksikoloških ispitivanja na životinjama u kojima su se koristila zamjenska protutijela ne ukazuje na povećan kancerogeni potencijal dupilumaba.
English: In addition, there was one patient with serum sickness and one with serum sickness-like reaction (< 0.1 %) associated with high ADA titers (see section 4.4).
Croatian: Osim toga, jedan je bolesnik imao serumsku bolest, a jedan reakciju nalik na serumsku bolest (< 0,1%) povezanu s visokim titrima protutijela na lijek (vidjeti dio 4.4).
English: Pull the needle out of the skin at the same angle it was inserted.
Croatian: Izvadite iglu iz kože pod istim kutom pod kojim ste je uboli.
English: CHRONOS at Week 52
Croatian: CHRONOS u 52. tjednu
English: Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site.
Croatian: Podignite palac da biste otpustili potisnik klipa i pričekajte da zaštitni pokrov prekrije iglu, a zatim uklonite štrcaljku s mjesta injiciranja.
English: An enhanced pre- and post-natal developmental study revealed no adverse effects in maternal animals or their offspring up to 6 months post-partum/post-birth.
Croatian: Prošireno ispitivanje prenatalnog i postnatalnog razvoja nije ukazalo na štetne učinke za majku ili mladunčad tijekom do 6 mjeseci nakon okota.
English: Do not stop using Dupixent without speaking to your doctor first.
Croatian: Nemojte prestati primjenjivati Dupixent bez prethodnog razgovora sa svojim liječnikom.
English: Dupixent can cause serious side effects, including very rare allergic (hypersensitivity) reactions, including anaphylactic reaction; the signs of allergic reaction or anaphylactic reaction may include:
Croatian: Dupixent može uzrokovati ozbiljne nuspojave, uključujući vrlo rijetke alergijske reakcije (reakcije preosjetljivosti) i anafilaktičku reakciju; znakovi alergijske reakcije ili anafilaktičke reakcije mogu uključivati:
English: You and your doctor should decide if you will breast-feed or use Dupixent.
Croatian: Vi i Vaš liječnik trebate odlučiti hoćete li dojiti ili primjenjivati Dupixent.
English: Very Common (may affect more than 1 in 10 people) atopic dermatitis and asthma: • injection site reactions (i.e. redness, swelling, and itching)
Croatian: Vrlo česte (mogu se javiti u više od 1 na 10 osoba) kod atopijskog dermatitisa i astme: • reakcije na mjestu injiciranja (tj. crvenilo, oticanje i svrbež)