FrancophonIA/ELRC3.0 huggingface dataset:
English: Variations in colour within this range do not affect the potency of the product.
Croatian: Varijacije u boji unutar tog raspona ne utječu na jačinu lijeka.
English: If you are told that you have an abnormal blood test (called Coombs test) tell your doctor that you are having or have recently had Zerbaxa.
Croatian: Ako Vam je rečeno da imate poremećen nalaz krvne pretrage (koja se naziva Coombsov test) obavijestite svog liječnika da primate ili ste nedavno primili lijek Zerbaxa.
English: AmpC enzymes (produced by Enterobacterales)
Croatian: AmpC enzime (koje proizvode Enterobacterales)
English: Environmental Risk Assessment (ERA)
Croatian: Procjena rizika za okoliš (ERA)
English: Minimum inhibitory concentration breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) are as follows:
Croatian: Granične vrijednosti minimalne inhibitorne koncentracije koje je ustanovilo Europsko povjerenstvo za ispitivanje osjetljivosti na antimikrobne lijekove (EUCAST) su sljedeće:
English: Treatment with Zerbaxa sometimes causes production of antibodies that react with your red blood cells.
Croatian: Liječenje lijekom Zerbaxa ponekad uzrokuje stvaranje protutijela koja reagiraju s Vašim crvenim krvnim stanicama.
English: Your doctor or other healthcare professional will give you this medicine into one of your veins through an infusion (a drip) lasting one hour.
Croatian: Ovaj će Vam lijek dati liječnik ili drugi zdravstveni radnik u jednu od vena putem infuzije (dripa) u trajanju od jednog sata.
English: If you are pregnant or breast-feeding, or think you may be pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite ili mislite da biste mogli biti trudni, obratite se svom liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek.
English: *To be used in combination with metronidazole when anaerobic pathogens are suspected.
Croatian: *Primjenjuje se u kombinaciji s metronidazolom kad se sumnja na anaerobne patogene.
English: Other medicines and Zerbaxa
Croatian: Drugi lijekovi i Zerbaxa
English: 8-14 days
Croatian: 8-14 dana
English: Zerbaxa is a medicine used to treat a range of bacterial infections.
Croatian: Zerbaxa je lijek koji se primjenjuje za liječenje niza bakterijskih infekcija.
English: Type of infection
Croatian: Vrsta infekcije
English: **To be used in combination with an antibacterial agent active against Gram-positive pathogens when these are known or suspected to be contributing to the infectious process.
Croatian: **Primjenjuje se u kombinaciji s antibakterijskim lijekom koji djeluje na Gram-pozitivne patogene kada je poznato ili kada se sumnja da pridonose infektivnom procesu.
English: Store in a refrigerator (2°C - 8°C).
Croatian: Čuvati u hladnjaku (2°C-8°C).
English: The infusion time is 1 hour for all doses of Zerbaxa.
Croatian: Trajanje infuzije iznosi 1 sat za sve doze lijeka Zerbaxa.
English: However, active substances that inhibit OAT1 or OAT3 (e.g., probenecid) may increase tazobactam plasma concentrations.
Croatian: Međutim, djelatne tvari koje inhibiraju OAT1 ili OAT3 (npr. probenecid) mogu povisiti koncentracije tazobaktama u plazmi.
English: Modification of PBPs
Croatian: modifikaciju PBP-ova.
English: From a microbiological point of view, the medicinal product should be used immediately upon reconstitution.
Croatian: S mikrobiološkog stajališta, lijek se mora primijeniti odmah nakon rekonstitucije.
English: Your doctor will advise if you should receive Zerbaxa during pregnancy.
Croatian: Liječnik će Vam savjetovati smijete li primati lijek Zerbaxa tijekom trudnoće.
English: Tell your doctor straight away if you get these symptoms as you may need urgent medical treatment: - Sudden swelling of your lips, face, throat or tongue; a severe rash; and, swallowing or breathing problems.
Croatian: Odmah obavijestite svog liječnika ukoliko dobijete sljedeće simptome jer ćete možda trebati hitnu liječničku pomoć: - naglo oticanje usana, lica, grla ili jezika; jaki osip; tegobe s gutanjem ili disanjem.
English: Your doctor may need to reduce the dose of Zerbaxa or decide how often Zerbaxa is given to you.
Croatian: Liječnik će Vam možda trebati sniziti dozu ili odlučiti koliko ćete često primati lijek Zerbaxa.
English: Animal studies with tazobactam have shown reproductive toxicity (see section 5.3) without evidence of teratogenic effects.
Croatian: Ispitivanja tazobaktama na životinjama pokazala su reproduktivnu toksičnost (vidjeti dio 5.3) bez dokaza teratogenih učinaka.
English: 4-14 days
Croatian: 4-14 dana
English: Precautions to be taken before handling or administering the product See section 6.2 for incompatibilities.
Croatian: Mjere opreza koje treba poduzeti prije rukovanja ili primjene lijeka Vidjeti dio 6.2 za inkompatibilnosti.
English: The preparation for each dose is shown below.
Croatian: Priprema svake doze prikazana je u nastavku.
English: If you think you have not been given a dose of Zerbaxa, tell your doctor or other healthcare professional immediately.
Croatian: Ako mislite da niste dobili dozu lijeka Zerbaxa, odmah o tome obavijestite liječnika ili drugog zdravstvenog radnika.
English: In this situation, you should not take medicines that stop or slow bowel movement
Croatian: U tom slučaju ne smijete uzimati lijekove koji zaustavljaju ili usporavaju rad crijeva.
English: What you need to know before you take Zerbaxa
Croatian: Što morate znati prije nego počnete primati lijek Zerbaxa
English: Tazobactam does not inhibit all Class A enzymes.
Croatian: Tazobaktam ne inhibira sve enzime klase A.
English: Frequency categories are derived according to the following conventions: common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100) (see Table 3).
Croatian: Kategorije učestalosti određene su prema sljedećoj konvenciji: često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100) (vidjeti tablicu 3).
English: In addition tazobactam does not inhibit the following types of beta-lactamase:
Croatian: Nadalje, tazobaktam ne inhibira sljedeće vrste beta-laktamaza:
English: Each vial is for single use only.
Croatian: Jedna bočica je samo za jednokratnu uporabu.
English: Preparation of doses
Croatian: Priprema doza
English: These types of infection may range in severity from mild to life-threatening.
Croatian: Ove vrste infekcija mogu biti različite težine, u rasponu od blagih do životno opasnih.
English: Approximately 66% of ceftolozane, 56% of tazobactam, and 51% of the M1 metabolite of tazobactam were removed by dialysis.
Croatian: Približno je 66% ceftolozana, 56% tazobaktama i 51% metabolita tazobaktama M1 bilo uklonjeno dijalizom.
English: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions are possible (see sections 4.3 and 4.8).
Croatian: Moguće su ozbiljne reakcije preosjetljivosti, ponekad i sa smrtnim ishodom (anafilaksija) (vidjeti dijelove 4.3 i 4.8).
English: In such circumstances, the discontinuation of therapy with ceftolozane/tazobactam and the use of supportive measures together with the administration of specific treatment for Clostridioides difficile should be considered.
Croatian: U takvim okolnostima potrebno je razmotriti prekid terapije ceftolozanom/tazobaktamom i primjenu potpornih mjera zajedno sa specifičnim liječenjem za Clostridioides difficile.
English: It contains two active substances: - ceftolozane, an antibiotic that belongs to the group of “cephalosporins” and which can kill certain bacteria that can cause infection; - tazobactam, which blocks the action of certain enzymes called beta-lactamases.
Croatian: Sadrži dvije djelatne tvari: - ceftolozan, antibiotik koji pripada skupini "cefalosporina" i koji može uništiti određene bakterije koje mogu uzrokovati infekciju; - tazobaktam, koji blokira djelovanje određenih enzima koji se zovu beta-laktamaze.
English: Pharmacokinetic/pharmacodynamic relationships
Croatian: Farmakokinetički/farmakodinamički odnosi
English: More than 80% of tazobactam was excreted as the parent compound with the remaining amount excreted as the tazobactam M1 metabolite.
Croatian: Više od 80% tazobaktama izlučilo se kao izvorni spoj, dok se preostala količina izlučila kao metabolit tazobaktama M1.
English: There is no experience with overdose of Zerbaxa.
Croatian: Nema iskustva s predoziranjem lijekom Zerbaxa.
English: Zerbaxa is for intravenous infusion.
Croatian: Zerbaxa se primjenjuje intravenskom infuzijom.
English: Talk to your doctor or pharmacist before taking Zerbaxa if you know you are, or have previously been allergic to cephalosporins, penicillins or other antibiotics.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primite lijek Zerbaxa ako znate da ste alergični ili ste bili alergični na cefalosporine, peniciline ili druge antibiotike.
English: 1, infusion site reactions
Croatian: 1, reakcije na mjestu primjene infuzije
English: It is an inhibitor of many molecular Class A beta-lactamases, including CTX-M, SHV, and TEM enzymes.
Croatian: On je inhibitor mnogih beta-laktamaza molekularne klase A, uključujući enzime CTX-M, SHV i TEM.
English: This medicine contains 230 mg sodium (main component of cooking/table salt) in each vial.
Croatian: Ovaj lijek sadrži 230 mg natrija (glavnog sastojka kuhinjske soli) u svakoj bočici.
English: Frequency Infusion time
Croatian: Trajanje infuzije
English: Environmental risk assessment studies have shown that one of the active ingredients, ceftolozane, may pose a risk to surface water organisms (see section 6.6).
Croatian: Ispitivanja procjene rizika za okoliš pokazala su da jedna od djelatnih tvari, ceftolozan, može predstavljati rizik za organizme površinskih voda (vidjeti dio 6.6).
English: These may be signs of a severe allergic reaction (anaphylaxis) and may be lifethreatening - Diarrhoea that becomes severe or does not go away or stool that contains blood or mucus during or after treatment with Zerbaxa.
Croatian: Ovo mogu biti znakovi teške alergijske reakcije (anafilaksije) i mogu biti opasne po život - proljev koji se razvije u teški ili koji ne prestaje, ili stolica koja sadrži krv ili sluz tijekom ili nakon liječenja lijekom Zerbaxa.
English: Direct antiglobulin test (Coombs test) seroconversion and potential risk of haemolytic anaemia
Croatian: Serokonverzija dokazana direktnim antiglobulinskim testom (Coombsov test) i mogući rizik od hemolitičke anemije
English: In the clinically evaluable (CE) patients, the clinical cure rates for ceftolozane/tazobactam were 95.9% in 293 patients aged less than 65 years and 87.8% in 82 patients aged 65 years or more.
Croatian: Među klinički ocjenjivim bolesnicima, stopa kliničkog izlječenja uz ceftolozan/tazobaktam iznosila je 95,9% u 293 bolesnika mlađih od 65 godina te 87,8% u 82 bolesnika u dobi od 65 ili više godina.
English: Production of beta-lactamases that can hydrolyse ceftolozane and which are not inhibited by tazobactam (see below)
Croatian: proizvodnju beta-laktamaza koje mogu hidrolizirati ceftolozan i koje ne inhibira tazobaktam (vidjeti u nastavku)
English: One of these 60 patients had bacteraemia at baseline.
Croatian: Jedan od tih 60 bolesnika je na početku ispitivanja imao bakterijemiju.
English: Mechanisms of bacterial resistance to ceftolozane/tazobactam include: i.
Croatian: Mehanizmi bakterijske rezistencije na ceftolozan/tazobaktam uključuju: i.
English: No dose adjustment is recommended based on gender.
Croatian: Ne preporučuje se prilagodba doze na temelju spola.
English: Pack size of 10 vials.
Croatian: Veličina pakiranja od 10 bočica.
English: The dose of medicine given to you depends on whether or not you have kidney problems.
Croatian: Doza lijeka koju će Vam dati ovisi o tome imate li tegobe s bubrezima.
English: Ceftolozane belongs to the cephalosporin class of antimicrobials.
Croatian: Ceftolozan pripada cefalosporinskoj klasi antibiotika.
English: To maintain similar systemic exposures to those with normal renal function, dosage adjustment is required (see section 4.2).
Croatian: Da bi se održale sistemske izloženosti slične izloženostima u onih s normalnom funkcijom bubrega, potrebna je prilagodba doze (vidjeti dio 4.2).
English: Tazobactam crosses the placenta.
Croatian: Tazobaktam prolazi kroz placentu.
English: It is not known if ceftolozane crosses the placenta.
Croatian: Nije poznato prolazi li ceftolozan kroz placentu.
English: If a severe allergic reaction occurs during treatment with ceftolozane/tazobactam, the medicinal product should be discontinued and appropriate measures taken.
Croatian: Ako tijekom liječenja ceftolozanom/tazobaktamom nastupi teška alergijska reakcija, potrebno je prekinuti primjenu lijeka i poduzeti odgovarajuće mjere.
English: The time above a threshold concentration has been determined to be the parameter that best predicts the efficacy of tazobactam in in vitro and in vivo non-clinical models.
Croatian: Utvrđeno je da je vrijeme iznad granične koncentracije parametar koji najbolje predviđa djelotvornost tazobaktama u nekliničkim modelima in vitro i in vivo.
English: The binding of ceftolozane and tazobactam to human plasma proteins is low (approximately 16% to 21% and 30%, respectively).
Croatian: Vezanje ceftolozana i tazobaktama za proteine ljudske plazme je nisko (približno 16% do 21% za ceftolozan, odnosno 30% za tazobaktam).
English: Common (≥ 1/100 to < 1/10)
Croatian: Često (≥1/100 i <1/10)
English: Zerbaxa may have a minor influence on the ability to drive and use machines.
Croatian: Zerbaxa može malo utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Zerbaxa therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Croatian: Potrebno je odlučiti da li prekinuti s dojenjem ili prekinuti liječenje/suzdržati se od liječenja lijekom Zerbaxa uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: If you stop taking Zerbaxa
Croatian: Ako prestanete primati lijek Zerbaxa
English: What Zerbaxa is and what it is used for What you need to know before you take Zerbaxa How to take Zerbaxa
Croatian: Što je Zerbaxa i za što se koristi Što morate znati prije nego počnete primati lijek Zerbaxa Kako primjenjivati lijek Zerbaxa Moguće nuspojave
English: See section 6.6 for instructions on reconstitution and dilution of the medicinal product before administration.
Croatian: Vidjeti dio 6.6 za upute o rekonstituciji i razrjeđivanju lijeka prije primjene.
English: Elderly (≥ 65 years of age) No dose adjustment is necessary for the elderly based on age alone (see section 5.2).
Croatian: Starije osobe (u dobi od ≥65 godina) U starijih osoba nije potrebno prilagođavati dozu samo na temelju dobi (vidjeti dio 5.2).
English: In the event of overdose, Zerbaxa should be discontinued and general supportive treatment given.
Croatian: U slučaju predoziranja, primjenu lijeka Zerbaxa treba prekinuti i uvesti opće potporno liječenje.
English: The use of ceftolozane/tazobactam may promote the overgrowth of non-susceptible micro-organisms.
Croatian: Primjena ceftolozana/tazobaktama može potaknuti pretjeran rast neosjetljivih mikroorganizama.
English: Gram-positive bacteria Streptococcus anginosus Streptococcus constellatus Streptococcus salivarius
Croatian: Gram-pozitivne bakterije Streptococcus anginosus Streptococcus constellatus Streptococcus salivarius
English: In subjects with end stage renal disease on haemodialysis, approximately two-thirds of the administered ceftolozane/tazobactam dose is removed by haemodialysis.
Croatian: U ispitanika sa završnim stadijem bolesti bubrega koji su na hemodijalizi, približno dvije trećine primijenjene doze ceftolozana/tazobaktama bude uklonjeno hemodijalizom.
English: In patients with moderate or severe renal impairment, and in patients with end stage renal disease on haemodialysis, the dose should be adjusted as listed in Table 2 (see sections 5.1 and 6.6).
Croatian: U bolesnika s umjerenim ili teškim oštećenjem funkcije bubrega i u bolesnika sa završnim stadijem bolesti bubrega koji su na hemodijalizi, dozu treba prilagoditi kako je navedeno u tablici 2 (vidjeti dijelove 5.1 i 6.6).
English: The Cmax and AUC of ceftolozane/tazobactam increase in proportion to dose.
Croatian: Cmax i AUC ceftolozana/tazobaktama povećavaju se proporcionalno dozi.
English: One of the active ingredients, ceftolozane, may have harmful effects if it reaches the aquatic environment.
Croatian: Jedna od djelatnih tvari, ceftolozan, može imati štetne učinke ako dospije u vodeni okoliš.
English: The resultant concentration is approximately 132 mg/mL (88 mg/mL of ceftolozane and 44 mg/mL of tazobactam) per vial.
Croatian: Dobivena koncentracija je približno 132 mg/ml (88 mg/ml ceftolozana i 44 mg/ml tazobaktama) po bočici.
English: No dose adjustment is recommended based on race.
Croatian: Ne preporučuje se prilagodba doze na temelju rase.
English: In a randomised active-controlled trial 18.2% (126/693) of microbiologically evaluable (ME) patients had complicated lower urinary tract infection, including 60/126 patients who were treated with ceftolozane/tazobactam.
Croatian: U randomiziranom ispitivanju kontroliranom aktivnim lijekom, 18,2% (126/693) mikrobiološki ocjenjivih bolesnika imalo je kompliciranu infekciju donjeg dijela mokraćnog sustava, uključujući 60/126 bolesnika liječenih ceftolozanom/tazobaktamom.
English: Pharmacotherapeutic group: Antibacterials for systemic use, other cephalosporins and penems, ATC code: J01DI54.
Croatian: Farmakoterapijska skupina: Pripravci za liječenje bakterijskih infekcija za sustavnu primjenu, ostali cefalosporini i penemi, ATK oznaka: J01DI54.
English: In a trial in patients with complicated intra-abdominal infections, the most common diagnosis was appendiceal perforation or peri-appendiceal abscess (420/970 [43.3%] patients), of which 137/420 (32.6%) had diffuse peritonitis at baseline.
Croatian: U ispitivanju provedenom u bolesnika s kompliciranim intraabdominalnim infekcijama, najčešća je dijagnoza bila perforacija apendiksa ili periapendikularni apsces (420/970 [43,3%] bolesnika); 137 od tih 420 bolesnika (32,6%) imalo je difuzni peritonitis na početku ispitivanja.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user, unless reconstitution/dilution has taken place in controlled and validated aseptic conditions and would normally not be longer than 24 hours at 2 to 8°C.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja i uvjeti čuvanja prije primjene odgovornost su korisnika, osim ako su rekonstitucija/razrjeđivanje provedeni u kontroliranim i validiranim aseptičkim uvjetima i normalno se lijek ne bi trebao čuvati dulje od 24 sata na temperaturi od 2 do 8°C.
English: Studies with ceftolozane in mice and rats have not shown evidence of reproductive toxicity or teratogenicity.
Croatian: U ispitivanjima ceftolozana u miševa i štakora nije bilo dokaza reproduktivne toksičnosti ili teratogenosti.
English: Ceftolozane exerts bactericidal activity through binding to important penicillin-binding proteins (PBPs), resulting in inhibition of bacterial cell-wall synthesis and subsequent cell death.
Croatian: Ceftolozan ostvaruje svoje baktericidno djelovanje vezanjem za važne proteine koji vežu penicilin (engl. penicillin-binding proteins, PBP), što rezultira inhibicijom sinteze bakterijske stanične stijenke i posljedičnom smrću stanice.
English: The mean terminal elimination half-life of ceftolozane and tazobactam in healthy adults with normal renal function is approximately 3 hours and 1 hour, respectively.
Croatian: Srednja vrijednost terminalnog poluvijeka eliminacije ceftolozana u zdravih odraslih osoba s normalnom funkcijom bubrega iznosi približno 3 sata, a tazobaktama 1 sat.
English: Some medicines may interact with ceftolozane and tazobactam.
Croatian: Neki lijekovi mogu ući u interakciju s ceftolozanom i tazobaktamom.
English: Infection due to C. difficile bacteria, C. difficile test positive (from stool test), Coombs test positive (a blood test that looks for antibodies that may fight against your red blood cells)
Croatian: Infekcija uzrokovana bakterijom C. difficile, pozitivan test na bakteriju C. difficile (u stolici), pozitivan Coombsov test (krvna pretraga kojom se traže protutijela koja napadaju crvene krvne stanice)
English: 1, venous thrombosis
Croatian: 1, venska tromboza
English: Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of ceftolozane/tazobactam.
Croatian: Stoga je važno uzeti u obzir ovu dijagnozu u bolesnika s dijarejom tijekom ili nakon primjene ceftolozana/tazobaktama.
English: Unopened vials: Store in a refrigerator (2°C - 8°C).
Croatian: Neotvorene bočice: Čuvati u hladnjaku (2°C-8°C).
English: There are no data on the use of ceftolozane/tazobactam in pregnant women.
Croatian: Nema podataka o primjeni ceftolozana/tazobaktama u trudnica.
English: In vitro, tazobactam inhibited human OAT1 and OAT3 transporters with IC50 values of 118 and 147 mcg/mL, respectively.
Croatian: In vitro, tazobaktam je inhibirao humane transportere OAT1 i OAT3 uz IC50 vrijednosti od 118 µg/ml za OAT1,odnosno 147 µg/ml za OAT3.
English: Talk to your doctor or pharmacist if you develop diarrhoea while taking Zerbaxa.
Croatian: Obratite se svom liječniku ili ljekarniku ako dobijete proljev tijekom primanja lijeka Zerbaxa.
English: If you are breast-feeding, your doctor will advise you on whether you should stop breast-feeding or stop or avoid Zerbaxa therapy, taking into account the benefit of breast-feeding for the child and the benefit of therapy for you.
Croatian: Ako dojite, liječnik će Vam savjetovati trebate li prekinuti dojenje ili prestati s terapijom ili izbjegavati terapiju lijekom Zerbaxa, uzimajući u obzir korist dojenja za dijete i korist liječenja za Vas.
English: Tazobactam is a beta-lactam structurally related to penicillins.
Croatian: Tazobaktam je beta-laktam strukturno sličan penicilinima.
English: In patients with mild renal impairment (estimated creatinine clearance [CrCL] > 50 mL/min), no dose adjustment is necessary, see section 5.2.
Croatian: U bolesnika s blagim oštećenjem funkcije bubrega (procijenjeni klirens kreatinina [CrCl] >50 ml/min) nije potrebno prilagođavati dozu, vidjeti dio 5.2.
English: Effects in non-clinical studies were observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use.
Croatian: U nekliničkim ispitivanjima zapaženi su učinci samo pri izloženostima dozama koje su znatno veće od maksimalno dozvoljenih u ljudi, što ukazuje na njihov mali značaj za kliničku primjenu.
English: Co-administration of ceftolozane/tazobactam with OAT1 and OAT3 substrate furosemide in a clinical study did not significantly increase furosemide plasma exposures (geometric mean ratios of 0.83 and 0.87 for Cmax and AUC, respectively).
Croatian: Istovremena primjena ceftolozana/tazobaktama s furosemidom, supstratom OAT1 i OAT3, u kliničkom ispitivanju nije značajno povećala izloženost furosemidu u plazmi (omjeri geometrijskih srednjih vrijednosti iznosili su 0,83 za Cmax i 0,87 za AUC).
English: Zerbaxa can be removed by haemodialysis.
Croatian: Zerbaxa se može ukloniti hemodijalizom.
English: Patients with renal impairment at baseline should be monitored frequently for any changes in renal function during treatment and the dose of ceftolozane/tazobactam should be adjusted as necessary.
Croatian: Bolesnike u kojih se na početku liječenja utvrdi oštećenje funkcije bubrega potrebno je često nadzirati zbog bilo kojih promjena u funkciji bubrega tijekom liječenja, a dozu ceftolozana/tazobaktama treba prilagoditi prema potrebi.
English: Efficacy has been demonstrated in clinical studies against the pathogens listed under each indication that were susceptible to Zerbaxa in vitro:
Croatian: U kliničkim je ispitivanjima dokazana djelotvornost protiv patogena navedenih za svaku indikaciju posebno, koji su bili osjetljivi na lijek Zerbaxa in vitro: