FrancophonIA/ELRC3.0 huggingface dataset:
English: The relative treatment effect of pemetrexed was internally consistent across subgroups (including disease stage, induction response, ECOG PS, smoking status, gender, histology and age) and similar to that observed in the unadjusted OS and PFS analyses.
Croatian: Relativan učinak liječenja pemetreksedom bio je konzistentan u svim podskupinama (uključujući podskupine prema stadiju bolesti, odgovoru na uvodno liječenje, ECOG izvedbeni status, pušački status, spol, histologiju i dob) te podjednak onome opaženom u nekorigiranim analizama OS-a i PFS-a.
English: Efficacy of pemetrexed vs docetaxel in NSCLC - ITT population Pemetrexed
Croatian: Djelotvornost primjene pemetrekseda naspram docetaksela kod NSCLC - ITT populacije Pemetreksed
English: If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with Pemetrexed Fresenius Kabi.
Croatian: Ako ste nedavno cijepljeni, obavijestite o tome svog liječnika jer to može izazvati štetne učinke uz primjenu lijeka Pemetrexed Fresenius Kabi.
English: If you have an accumulation of fluid around your lungs, your doctor may decide to remove the fluid before giving you Pemetrexed Fresenius Kabi.
Croatian: Ako Vam se oko pluća nakupila tekućina, liječnik može odlučiti ukloniti tu tekućinu prije primjene lijeka Pemetrexed Fresenius Kabi.
English: Therefore patients should be cautioned against driving or operating machines if this event occurs.
Croatian: Stoga se bolesnike mora upozoriti da u tom slučaju ne upravljaju vozilima niti rukuju strojevima.
English: Children and adolescents There is no relevant use of Pemetrexed Fresenius Kabi in the paediatric population
Croatian: Djeca i adolescenti Pemetrexed Fresenius Kabi nema relevantne primjene u pedijatrijskoj populaciji.
English: Hypernatraemia - increased sodium in blood Inflammation of the skin, mainly of the lower limb with swelling, pain and redness
Croatian: Hipernatremija - povećana razina natrija u krvi Upala kože koja se uglavnom javlja na donjim udovima, a praćena je oticanjem, boli i crvenilom
English: As with other potentially toxic anticancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions.
Croatian: Kao i kod svih potencijalno toksičnih lijekova za liječenje raka, treba biti oprezan pri rukovanju i pripremi otopine pemetrekseda za infuziju.
English: Dose for cisplatin (mg/m
Croatian: Doza cisplatina (mg/m2)
English: Excipients: Mannitol, hydrochloric acid concentrated, trometamol
Croatian: Pomoćne tvari: manitol, koncentrirana kloridna kiselina, trometamol
English: Very common( may affect more than 1 in 10 people) Low white blood cells
Croatian: Vrlo česte: (mogu se javiti u više od 1 na 10 osoba) Nizak broj bijelih krvnih stanica Niska razina hemoglobina (anemija) Nizak broj krvnih pločica
English: Limited clinical data from a separate randomized, Phase 3, controlled trial, suggest that efficacy data (overall survival, progression free survival) for pemetrexed are similar between patients previously pre treated with docetaxel (n = 41) and patients who did not receive previous docetaxel treatment (n = 540).
Croatian: Ograničeni klinički podaci iz zasebnog randomiziranog kontroliranog ispitivanja faze 3 ukazuju na to da su podaci o djelotvornosti (ukupno preživljenje, preživljenje bez progresije bolesti) za pemetreksed slični u bolesnika prethodno liječenih docetakselom (n = 41) i bolesnika koji prethodno nisu primali docetaksel (n = 540).
English: How to store Pemetrexed Fresenius Kabi Contents of the pack and other information
Croatian: Kako čuvati lijek Pemetrexed Fresenius Kabi Sadržaj pakiranja i druge informacije
English: For precautions to be taken before handling or administering Pemetrexed Fresenius Kabi, see section 6.6.
Croatian: Za mjere opreza koje treba poduzeti prije rukovanja lijekom ili primjene lijeka Pemetrexed Fresenius Kabi, vidjeti dio 6.6.
English: Pemetrexed Fresenius Kabi should be administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Croatian: Pemetrexed Fresenius Kabi se mora primjenjivati u obliku intravenske infuzije u trajanju od 10 minuta prvog dana svakog 21-dnevnog ciklusa.
English: Germany
Croatian: Njemačka ili
English: The PFS and OS results in patients with squamous cell histology suggested no advantage for pemetrexed over placebo.
Croatian: Rezultati PFS-a i ukupnog preživljenja u bolesnika s histologijom pločastih stanica nisu pokazali prednost pemetrekseda nad placebom.
English: Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1000 micrograms) that you must take once a day while you are taking Pemetrexed Fresenius Kabi.
Croatian: Vitaminska nadoknada: liječnik će Vam propisati folatnu kiselinu (vitamin) koja se uzima kroz usta ili multivitaminski pripravak koji sadrži folatnu kiselinu (350 do 1000 mikrograma), koji morate uzimati jedanput na dan za vrijeme liječenja lijekom Pemetrexed Fresenius Kabi.
English: *Refer to National Cancer Institute CTC version 2 for each grade of toxicity except the term “creatinine clearance decreased” ** which is derived from the term “renal/genitourinary other”.
Croatian: * Za sve stupnjeve toksičnosti vidjeti Zajedničke kriterije toksičnosti (CTC) Nacionalnog Instituta za rak verziju 2, osim za izraz „smanjen klirens kreatinina“ ** Izveden iz izraza „ostali bubrežni/genitourinarni poremećaji“.
English: When prepared as directed, reconstituted and infusion solutions of Pemetrexed Fresenius Kabi contain no antimicrobial preservatives.
Croatian: Kada se pripremaju prema uputama, rekonstituirana otopina i otopina za infuziju lijeka Pemetrexed Fresenius Kabi ne sadrže antimikrobne konzervanse.
English: Use aseptic techniques during the reconstitution and further dilution of pemetrexed for intravenous infusion administration.
Croatian: Koristiti aseptičku tehniku prilikom rekonstitucije i daljnjeg razrjeđivanja pemetrekseda za primjenu u intravenskoj infuziji.
English: Abbreviation: CI = confidence interval * p-value refers to comparison between arms.
Croatian: Kratice: CI = interval pouzdanosti * p-vrijednost se odnosi na usporedbu između dviju skupina bolesnika.
English: Abbreviations: CI = confidence interval; HR = hazard ratio; ITT = intent to treat; n = total population size.
Croatian: Kratice: CI = interval pouzdanosti; HR = omjer hazarda; ITT = populacija predviđena za liječenje ; n = ukupna veličina populacije.
English: Pemetrexed can suppress bone marrow function as manifested by neutropenia, thrombocytopenia and anaemia (or pancytopenia) (see section 4.8).
Croatian: Pemetreksed može suprimirati funkciju koštane srži, što se manifestira neutropenijom, trombocitopenijom i anemijom (ili pancitopenijom) (vidjeti dio 4.8).
English: Concomitant administration of nephrotoxic medicinal product (e.g. aminoglycoside, loop diuretics, platinum compounds, cyclosporin) could potentially result in delayed clearance of pemetrexed.
Croatian: Istodobna primjena s nefrotoksičnim lijekovima (npr. aminoglikozidom, diureticima Henleove petlje, spojevima platine, ciklosporinom) može rezultirati odgođenim klirensom pemetrekseda.
English: Clinically relevant Grade 3 and Grade 4 laboratory toxicities were similar between integrated Phase 2 results from three single agent pemetrexed studies (n = 164) and the Phase 3 single agent pemetrexed study described above, with the exception of neutropenia (12.8 % versus 5.3 %, respectively) and alanine aminotransferase elevation (15.2 % versus 1.9 %, respectively).
Croatian: Klinički značajni oblici toksičnosti stupnja 3 i 4 utvrđeni laboratorijskim pretragama bili su podjednaki u objedinjenim rezultatima triju ispitivanja faze 2 pemetrekseda u monoterapiji (n = 164) i rezultatima gore opisanog kliničkog ispitivanja faze 3 pemetrekseda u monoterapiji, s iznimkom neutropenije (12,8% naspram 5,3%) i povišenih vrijednosti alanin aminotransferaze (15,2% naspram 1,9%).
English: In patients with normal renal function (creatinine clearance > 80 ml/min), high doses of non-steroidal anti-inflammatory medicinal product (NSAIDs, such as ibuprofen > 1600 mg/day) and acetylsalicylic acid at higher dose (> 1.3 g daily) may decrease pemetrexed elimination and, consequently, increase the occurrence of pemetrexed adverse events.
Croatian: U bolesnika s normalnom funkcijom bubrega (klirens kreatinina ≥ 80 ml/min) visoke doze nesteroidnih protuupalnih lijekova (NSAIL, poput ibuprofena > 1600 mg na dan) i više doze acetilsalicilatne kiseline (≥ 1,3 g na dan) mogu smanjiti eliminaciju pemetrekseda i, posljedično povećati pojavu štetnih događaja izazvanih pemetreksedom.
English: Contact your doctor if you get a severe rash, or itching, or blistering (Stevens-Johnson
Croatian: Obratite se liječniku ako dobijete težak osip, svrbež ili mjehuriće na koži (Stevens- Johnsonov sindrom ili toksična epidermalna nekroliza).
English: Patients with renal impairment (Standard Cockcroft and Gault formula or Glomerular Filtration Rate measured Tc99m-DPTA serum clearance method)
Croatian: Bolesnici s oštećenjem bubrega (Serumski klirens izračunat standardnom Cockcroftovom i Gaultovom formulom ili metodom mjerenja brzine glomerularne filtracije Tc99m-DPTA)
English: It is not known whether pemetrexed is excreted in human milk and adverse reactions on the suckling child cannot be excluded.
Croatian: Nije poznato izlučuje li se pemetreksed u majčino mlijeko pa se ne mogu isključiti nuspojave na dojenče.
English: Rare cases of radiation recall have been reported in patients who have received radiotherapy previously (see section 4.4).
Croatian: Slučajevi odzivne radijacijske upalne reakcije prijavljeni su rijetko u bolesnika koji su prethodno liječeni radioterapijom (vidjeti dio 4.4).
English: What Pemetrexed Fresenius Kabi is and what it is used for What you need to know before you use Pemetrexed Fresenius Kabi How to use Pemetrexed Fresenius Kabi Possible side effects
Croatian: Što je Pemetrexed Fresenius Kabi i za što se koristi Što morate znati prije nego počnete primjenjivati lijek Pemetrexed Fresenius Kabi
English: If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), Pemetrexed Fresenius Kabi should be withheld until resolution to less than or equal to the patient's pre-therapy value.
Croatian: Razvije li se u bolesnika nehematološka toksičnost stupnja ≥ 3 (osim neurotoksičnosti), primjena lijeka Pemetrexed Fresenius Kabi mora se prekinuti dok se vrijednosti ne vrate na razinu prije liječenja ili nižu.
English: These differences were likely due to differences in the patient population, since the Phase 2 studies included both chemonaive and heavily pre-treated breast cancer patients with pre-existing liver metastases and/or abnormal baseline liver function tests.
Croatian: Te su razlike vjerojatno posljedica razlika između populacija bolesnika, s obzirom da su u ispitivanja faze 2 bile uključene i bolesnice s rakom dojke koje prethodno nisu primale kemoterapiju i one koje su prethodno primale više linija terapije i imale metastaze u jetri i/ili abnormalne vrijednosti jetrenih enzima na početku ispitivanja.
English: ▪ If you experience bleeding from the gums, nose or mouth or any bleeding that would not stop, reddish or pinkish urine, unexpected bruising (since you might have less platelets than normal which is very common).
Croatian: ▪ ako imate krvarenje iz desni, nosa ili usta ili bilo kakvo krvarenje koje ne prestaje, crvenkastu ili ružičastu boju mokraće, neočekivane modrice (jer broj krvnih pločica može biti niži od normalnog, što je vrlo česta pojava).
English: Abbreviations: CI = confidence interval; ITT = intent-to-treat; N = total population size.
Croatian: Kratice: CI = interval pouzdanosti; ITT = populacija predviđena za liječenje; n = ukupna veličina populacije.
English: Do not use Pemetrexed Fresenius Kabi if you are allergic to pemetrexed or any of the other ingredients of this medicine (listed in section 6).
Croatian: Što morate znati prije nego počnete primjenjivati lijek Pemetrexed Fresenius Kabi Nemojte koristiti lijek Pemetrexed Fresenius Kabi - ako ste alergični na pemetreksed ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: 75 % of previous dose 75 % of previous dose
Croatian: 75% prethodne doze
English: You must contact your doctor immediately if you notice any of the following: ▪ Fever or infection (common): if you have a temperature of 38ºC or greater, sweating or other signs of infection (since you might have less white blood cells than normal which is very common).
Croatian: ▪ vrućicu ili infekciju (često): ako Vam je tjelesna temperatura 38°C ili viša, ako se znojite ili imate neke druge znakove infekcije (jer broj bijelih krvnih stanica može biti niži od normalnog, što je vrlo česta pojava).
English: There were no clinically relevant differences observed for the safety profile of pemetrexed within the histology subgroups.
Croatian: Nije bilo klinički značajnih razlika u sigurnosnom profilu pemetrekseda unutar histoloških podskupina.
English: MARKETING AUTHORISATION NUMBER EU/1/16/1115/002
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE GOTOVOG LIJEKA U PROMET EU/1/16/1115/002
English: Before the start of any cycle of chemotherapy, patients are required to have the following: absolute neutrophil count (ANC) should be ≥ 1500 cells/mm and platelets should be
Croatian: Prije početka svakog ciklusa kemoterapije bolesnici moraju imati sljedeće vrijednosti laboratorijskih parametara: apsolutni broj neutrofila (ABN) mora biti ≥ 1500 stanica/mm3, a broj trombocita mora biti ≥ 100 000 stanica/mm3.
English: Pemetrexed is a multi-targeted anti-cancer antifolate agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication.
Croatian: Pemetreksed je lijek za liječenje raka s višestrukim antifolatnim djelovanjem koji djeluje tako da prekida ključne metaboličke procese ovisne o folatima neophodne za umnažanje stanica.
English: Pemetrexed Fresenius Kabi in combination with cisplatin The recommended dose of Pemetrexed Fresenius Kabi is 500 mg/m of body surface area (BSA) administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Croatian: Pemetrexed Fresenius Kabi u kombinaciji s cisplatinom Preporučena doza lijeka Pemetrexed Fresenius Kabi je 500 mg/m2 tjelesne površine, a primjenjuje se u obliku intravenske infuzije tijekom 10 minuta, prvog dana svakog 21-dnevnog ciklusa.
English: The most commonly reported undesirable effects related to pemetrexed, whether used as monotherapy or in combination, are bone marrow suppression manifested as anaemia, neutropenia, leukopenia, thrombocytopenia; and gastrointestinal toxicities, manifested as anorexia, nausea, vomiting, diarrhoea, constipation, pharyngitis, mucositis, and stomatitis.
Croatian: Najčešće prijavljene nuspojave povezane s primjenom pemetrekseda, kako u monoterapiji tako i u kombinaciji s drugim lijekovima, su supresija koštane srži, koja se očituje kao anemija, neutropenija, leukopenija ili trombocitopenija; i gastrointestinalna toksičnost, koja se manifestira kao anoreksija, mučnina, povraćanje, proljev, konstipacija, faringitis, mukozitis i stomatitis.
English: Intravenous use after reconstitution and dilution.
Croatian: Za primjenu u venu nakon rekonstitucije i razrjeđivanja.
English: Fully supplemented patients
Croatian: Bolesnici s potpunim bolesnici nadomjeskom
English: Patients should be monitored for myelosuppression during therapy and pemetrexed should not be given to patients until absolute neutrophil count (ANC) returns to ≥ 1500 cells/mm and platelet count returns to ≥ 100,000 cells/mm
Croatian: U bolesnika se tijekom liječenja moraju pratiti pokazatelji mijelosupresije i pemetreksed se ne smije davati sve dok apsolutni broj neutrofila (ABN) ne bude ≥ 1500 stanica/mm3, a broj trombocita  100 000 stanica/mm3.
English: Infectious and non-infectious disorders of the dermis, the hypodermis and/or the subcutaneous tissue have been reported with an unknown frequency (e.g. acute bacterial dermo-hypodermitis,
Croatian: Prijavljeni su infektivni i neinfektivni poremećaji dermisa, hipodermisa i/ili supkutanog tkiva, čija je učestalost nepoznata (npr. akutna bakterijska upala dermisa i hipodermisa, pseudocelulitis i dermatitis).
English: After reconstitution, the solution contains 25 mg/ml of pemetrexed.
Croatian: Nakon rekonstitucije, otopina sadrži 25 mg/ml pemetrekseda.
English: There is no relevant use of Pemetrexed Fresenius Kabi in the paediatric population in malignant pleural mesothelioma and non-small cell lung cancer.
Croatian: Nije opravdana primjena lijeka Pemetrexed Fresenius Kabi u pedijatrijskoj populaciji u indikaciji malignog pleuralnog mezotelioma i raka pluća nemalih stanica.
English: Hydrochloric acid concentrated (E507) (pH adjustment) Trometamol (pH adjustment)
Croatian: 6.1 Popis pomoćnih tvari manitol (E421) kloridna kiselina, koncentrirana (E507) (za podešavanje pH vrijednosti) trometamol (za podešavanje pH vrijednosti) 6.2 Inkompatibilnosti
English: Calculate the dose and the number of Pemetrexed Fresenius Kabi vials needed.
Croatian: Izračunajte dozu i potreban broj bočica lijeka Pemetrexed Fresenius Kabi.
English: Patients treated with pemetrexed and cisplatin required fewer transfusions (16.4% versus 28.9%, p<0.001), red blood cell transfusions (16.1% versus 27.3%, p<0.001) and platelet transfusions (1.8% versus 4.5%, p=0.002).
Croatian: Bolesnici liječeni pemetreksedom i cisplatinom trebali su manje transfuzija (16,4% naspram 28,9%, p < 0,001), transfuzija eritrocita (16,1% naspram 27,3%, p < 0,001) i transfuzija trombocita (1,8% naspram 4,5%, p = 0,002).
English: There is not a specific antidote for extravasation of pemetrexed.
Croatian: U slučaju ekstravazacije pemetrekseda nema specifičnog antidota.
English: However patients with hepatic impairment such as bilirubin > 1.5 times the upper limit of normal and/or aminotransferase > 3.0 times the upper limit of normal (hepatic metastases absent) or > 5.0 times the upper limit of normal (hepatic metastases present) have not been specifically studied.
Croatian: Međutim, nisu posebno ispitivani bolesnici s oštećenjem jetre u kojih je vrijednost bilirubina bila > 1,5 puta iznad gornje granice normale i/ili vrijednost aminotransferaze > 3,0 puta iznad gornje granice normale (bez metastaza u jetri) odnosno > 5,0 puta iznad gornje granice normale (uz metastaze u jetri).
English: Progression free survival (PFS) and overall response rate were similar between treatment arms: median PFS was 4.8 months for pemetrexed plus cisplatin versus 5.1 months for gemcitabine plus cisplatin (adjusted hazard ratio 1.04; 95% CI = 0.94-1.15), and overall response rate was 30.6% (95% CI = 27.3-33.9) for pemetrexed plus cisplatin versus 28.2% (95% CI = 25.0-31.4) for gemcitabine plus cisplatin.
Croatian: Preživljenje bez progresije bolesti (PFS) i stopa ukupnog odgovora bili su podjednaki između liječenih skupina: medijan PFS-a iznosio je 4,8 mjeseci za pemetreksed i cisplatin naspram 5,1 mjeseci za gemcitabin i cisplatin (prilagođen omjer hazarda 1,04; 95% CI = 0,94-1,15), a stopa ukupnog odgovora bila je 30,6% (95% CI = 27,3-33,9) za pemetreksed i cisplatin naspram 28,2% (95% CI = 25,0-31,4) za gemcitabin i cisplatin.
English: Pemetrexed Fresenius Kabi must only be administered under the supervision of a physician qualified in the use of anti-cancer chemotherapy.
Croatian: Pemetrexed Fresenius Kabi se mora primjenjivati samo pod nadzorom liječnika koji je kvalificiran za primjenu kemoterapije raka.
English: A phase 2 study of pemetrexed in 31 solid tumour patients with stable third space fluid demonstrated no difference in pemetrexed dose normalized plasma concentrations or clearance compared to patients without third space fluid collections.
Croatian: U ispitivanju pemetrekseda faze 2 u 31 bolesnika sa solidnim tumorom i stabilnom tekućinom u transcelularnom prostoru nije uočena razlika u koncentracijama pemetrekseda u plazmi normaliziranima za dozu, kao ni u klirensu pemetrekseda, u usporedbi s bolesnicima koji nisu imali nakupljanje tekućine u transcelularnom prostoru.
English: Pemetrexed Fresenius Kabi can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Croatian: Vam se može propisati ako imate rak pluća u uznapredovalom stadiju i ako je Vaša bolest reagirala na liječenje ili ostala uglavnom nepromijenjena nakon početne kemoterapije.
English: Breast-feeding must be discontinued during pemetrexed therapy (see section 4.3).
Croatian: Za vrijeme terapije pemetreksedom dojenje se mora prekinuti (vidjeti dio 4.3).
English: ▪ If you experience tiredness, feeling faint, becoming easily breathless or if you look pale (since you might have less haemoglobin than normal which is very common).
Croatian: ▪ ako osjetite umor, nesvjesticu, nedostatak zraka ili ste blijedi (jer razina hemoglobina može biti niža od normalne, što je vrlo česta pojava).
English: Pemetrexed Fresenius Kabi is also given in combination with cisplatin for the initial treatment of patients with advanced stage of lung cancer.
Croatian: Pemetrexed Fresenius Kabi se također primjenjuje u kombinaciji s cisplatinom za početno liječenje bolesnika s uznapredovalim stadijem raka pluća.
English: The use of calcium folinate / folinic acid in the management of pemetrexed overdose should be considered.
Croatian: U liječenju predoziranja pemetreksedom potrebno je razmotriti primjenu kalcijeva folinata/folinatne kiseline.
English: Uncommon cases of acute renal failure have been reported with pemetrexed alone or in association with other chemotherapeutic agents (see section 4.4).
Croatian: Slučajevi akutnog zatajenja bubrega prijavljeni su manje često kod primjene pemetrekseda u monoterapiji ili u kombinaciji s drugim kemoterapeuticima (vidjeti dio 4.4).
English: If you have had or are going to have radiation therapy, please tell your doctor, as there may be an early or late radiation reaction with Pemetrexed Fresenius Kabi.
Croatian: Ako ste primali ili ćete primati terapiju zračenjem, obavijestite o tome svog liječnika jer se uz primjenu lijeka Pemetrexed Fresenius Kabi mogu pojaviti rane ili kasne reakcije na zračenje.
English: Pemetrexed Fresenius Kabi is given in combination with cisplatin, another anti-cancer medicine, as treatment for malignant pleural mesothelioma, a form of cancer that affects the lining of the lung, to patients who have not received prior chemotherapy.
Croatian: Pemetrexed Fresenius Kabi se primjenjuje u kombinaciji s cisplatinom, još jednim lijekom za liječenje raka, za liječenje zloćudnog pleuralnog mezotelioma, oblika raka koji zahvaća plućne ovojnice, u bolesnika koji prethodno nisu primali kemoterapiju.
English: In the absence of data regarding potential interaction with NSAIDs having longer half-lives such as piroxicam or rofecoxib, the concomitant administration with pemetrexed in patients with mild to moderate renal insufficiency should be interrupted for at least 5 days prior to, on the day of, and at least 2 days following pemetrexed administration (see section 4.4).
Croatian: U nedostatku podataka o mogućim interakcijama s NSAIL s duljim poluvijekom, poput piroksikama ili rofekoksiba, u bolesnika s blagim do umjerenim zatajenjem bubrega, njihova se istodobna primjena mora prekinuti najmanje 5 dana prije, na sam dan i najmanje 2 dana nakon primjene pemetrekseda (vidjeti dio 4.4).
English: Nadir platelets < 50,000 /mm regardless of nadir ANC
Croatian: Najniži broj trombocita < 50 000 /mm3 bez obzira na najniži ABN
English: Pemetrexed Fresenius Kabi is also a treatment for patients with advanced stage of lung cancer whose disease has progressed after other initial chemotherapy has been used.
Croatian: Pemetrexed Fresenius Kabi se također primjenjuje za liječenje bolesnika s uznapredovalim stadijem raka pluća u kojih je bolest napredovala nakon primjene neke druge početne kemoterapije.
English: It is a white to off-white lyophilised powder or solid.
Croatian: To je liofilizirani prašak ili krutina bijele do bjelkaste boje.