FrancophonIA/ELRC3.0 huggingface dataset:
English: Co-administration with Genvoya may increase dabigatran plasma concentrations with similar effects as seen with other strong P-gp inhibitors.
Danish: Samtidig administration af Genvoya kan føre til øgede plasmakoncentrationer af dabigatran med lignende virkninger som ved andre kraftige hæmmere af P-gp.
English: Dose modifications are not necessary when rosuvastatin is administered in combination with Genvoya.
Danish: Dosismodifikationer er ikke nødvendige ved samtidig administration af rosuvastatin og Genvoya.
English: Steady-state mean Cmax and AUCtau for tenofovir alafenamide were 0.16 ± 0.08 µg/mL and 0.21 ± 0.15 µg•h/mL, respectively.
Danish: Steady-state gennemsnitlige værdier for Cmax og AUCtau for tenofoviralafenamid var hhv. 0,16 ± 0,08 µg/ml og 0,21 ± 0,15 µg•t/ml for tenofovir.
English: Concentrations of warfarin may be affected upon co-administration with Genvoya.
Danish: Koncentrationer af warfarin kan påvirkes ved samtidig administration af Genvoya.
English: The antiviral activity of tenofovir alafenamide against laboratory and clinical isolates of HIV-1 subtype B was assessed in lymphoblastoid cell lines, PBMCs, primary monocyte/macrophage cells and CD4+-T lymphocytes.
Danish: Den antivirale aktivitet af tenofoviralafenamid mod isolater af hiv 1 undertype B fra laboratoriet og klinikken blev vurderet i lymfoblastoide cellelinjer, PBMC'er, primære monocyt-/makrofage celler og CD4+ T-lymfocytter.
English: The mean baseline CD4+ cell count was 545 cells/mm3 (range 205-1473).
Danish: Det gennemsnitlige CD4+ celletal ved baseline var 545 celler/mm3 (interval: 205-1473).
English: These findings should be considered for any child exposed in utero to nucleos(t)ide analogues, who present with severe clinical findings of unknown aetiology, particularly neurologic findings.
Danish: Mitokondriel dysfunktion bør overvejes hos alle børn med svære kliniske symptomer af ukendt ætiologi, især neurologiske symptomer, der har været eksponeret for nukleosid-/nukleotidanaloger in utero.
English: There is insufficient information on the effects of elvitegravir, cobicistat, emtricitabine and tenofovir in newborns/infants.
Danish: Der foreligger utilstrækkelige data for virkningen af elvitegravir, cobicistat, emtricitabin og tenofovir på det ammede barn.
English: Mean exposures of elvitegravir, cobicistat, emtricitabine, tenofovir, and tenofovir alafenamide achieved in children aged 8 to < 12 years (> 25 kg; n = 23) who received Genvoya in study GS-US-292-0106 were higher (20 to 80%) than the mean exposures achieved in adults (Table 6).
Danish: Gennemsnitseksponeringer for elvitegravir, cobicistat, emtricitabin, tenofovir og tenofoviralafenamid, der blev opnået hos børn i alderen 8 til < 12 år (> 25 kg; n = 23), som fik Genvoya i studie GS-US-292-0106, var højere (20 til 80 %) end gennemsnitseksponeringer hos voksne (Tabel 6).
English: At baseline, mean plasma HIV-1 RNA was 4.6 log10 copies/mL, median CD4+ cell count was 456 cells/mm3 (range: 95 to 1,110), and median CD4+% was 23% (range: 7 to 45%).
Danish: Ved baseline var gennemsnitligt hiv 1-rna i plasma 4,6 log10 kopier/ml, median CD4+ celletal var 456 celler/mm3 (interval: 95 til 1.110), og median CD4+ % var 23 % (interval: 7 til 45 %).
English: Emtricitabine displayed antiviral activity in cell culture against HIV-1 clades A, B, C, D, E, F, and G (EC50 values ranged from 0.007 to 0.075 µM) and showed strain specific activity against HIV-2 (EC50 values ranged from 0.007 to 1.5 µM).
Danish: Emtricitabin viste antiviral aktivitet i cellekultur mod hiv 1-kladerne A, B, C, D, E, F og G (EC50-værdier var i intervallet fra 0,007 til 0,075 µM) og viste stammespecifik aktivitet mod hiv 2 (EC50-værdier var i intervallet fra 0,007 til 1,5 µM).
English: If you feel dizzy when taking Genvoya, do not drive or ride a bicycle and do not use any tools or machines.
Danish: Kør ikke motorkøretøj, lad være med at cykle og lad være med at arbejde med værktøj eller maskiner, hvis De bliver svimmel, når De tager Genvoya.
English: Following oral administration of [14C]-elvitegravir/ritonavir, 94.8% of the dose was recovered in faeces, consistent with the hepatobiliary excretion of elvitegravir; 6.7% of the administered dose was recovered in urine.
Danish: Efter oral administration af [14C]-elvitegravir/ritonavir blev 94,8 % af dosis genfundet i fæces i overensstemmelse med den hepatobiliære udskillelse af elvitegravir.
English: The safety of Genvoya in 55 virologically suppressed HIV-1 infected patients with end stage renal disease (eGFRCG < 15 mL/min) on chronic haemodialysis was evaluated through 48 weeks in a single arm, open-label clinical study (GS-US-292-1825).
Danish: Sikkerheden af Genvoya hos 55 virologisk supprimerede hiv 1-inficerede patienter med nyresygdom i slutstadie (eGFRCG < 15 ml/min) i kronisk hæmodialyse blev evalueret til og med 48 uger i et ublindet klinisk studie med én behandlingsarm (GS-US-292-1825).
English: Concentrations of voriconazole may increase or decrease when co-administered with Genvoya.
Danish: Koncentrationer af voriconazol kan øges eller reduceres ved samtidig administration af Genvoya.
English: Genvoya should not be administered concomitantly with medicinal products containing tenofovir alafenamide, tenofovir disoproxil, lamivudine or adefovir dipivoxil used for the treatment of HBV infection (see section 4.5).
Danish: Genvoya bør ikke administreres sammen med lægemidler, som indeholder tenofoviralafenamid, tenofovirdisoproxil, lamivudin eller adefovirdipivoxil, der anvendes til behandling af infektion med HBV (se pkt.
English: Co-administration with Genvoya may result in increased plasma concentrations of sildenafil and tadalafil, which may result in PDE-5 inhibitor-associated adverse reactions.
Danish: Samtidig administration med Genvoya kan føre til øgede plasmakoncentrationer af sildenafil og tadalafil, hvilket kan føre til bivirkninger associeret med PDE-5hæmmeren.
English: There are no pharmacokinetic data on elvitegravir, cobicistat, emtricitabine or tenofovir alafenamide in patients with end stage renal disease (estimated CrCl < 15 mL/min) not on chronic haemodialysis.
Danish: Der foreligger ingen farmakokinetiske data om elvitegravir, cobicistat, emtricitabin eller tenofoviralafenamid hos patienter med nyresygdom i slutstadiet (estimeret CrCl < 15 ml/min), som ikke er i kronisk hæmodialyse.
English: In a clinical study of HIV virologically suppressed patients co-infected with chronic hepatitis B, who received Genvoya for 48 weeks (GS-US-292-1249, n = 72), 2 patients qualified for resistance analysis.
Danish: Hos patienter med samtidig infektion med hiv og HBV I et klinisk studie med hiv-inficerede, virologisk supprimerede patienter med samtidig infektion med kronisk hepatitis B, som fik Genvoya i 48 uger (GS-US-292-1249, n = 72), var 2 patienter kvalificerede til resistensanalyse.
English: colchicine
Danish: - colchicin
English: The mean increase from baseline in CD4+ cell count at Week 48 was 224 cells/mm3.
Danish: Den gennemsnitlige stigning fra baseline i CD4+ celletal ved uge 48 var 224 celler/mm3.
English: After switching to Genvoya, 90% (45/50) of patients remained suppressed (HIV-1 RNA < 50 copies/mL) at Week 48.
Danish: Efter skift til Genvoya forblev 90 % (45/50) af patienterne supprimerede (hiv 1-rna < 50 kopier/ml) ved 48 uger.
English: Genvoya 150 mg/150 mg/200 mg/10 mg film-coated tablets Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
Danish: Genvoya 150 mg/150 mg/200 mg/10 mg filmovertrukne tabletter Elvitegravir/cobicistat/emtricitabin/tenofoviralafenamid
English: The mean baseline CD4+ cell count was 427 cells/mm3 (range 0-1,360) and 13% had a CD4+ cell count < 200 cells/mm3.
Danish: Det gennemsnitlige CD4+ celletal ved baseline var 427 celler/mm3 (interval 0-1.360), og 13 % havde et CD4+ celletal på < 200 celler/mm3.
English: Patients in Cohort 1 had a mean age of 15 years (range 12 to 17), were 44% male, 12% Asian, and 88% Black.
Danish: Patienterne i kohorte 1 havde en gennemsnitsalder på 15 år (interval: 12 til 17 år), 44 % var mænd, 12 % var asiater, og 88 % var sorte.
English: • tenofovir disoproxil
Danish: • tenofovirdisoproxil
English: ANTIARRHYTHMICS Digoxin (0.5 mg single dose)/ Cobicistat (150 mg multiple doses)
Danish: ANTIARYTMIKA Digoxin (0,5 mg enkeltdosis)/ Cobicistat (150 mg flerdosis)
English: Of the HIV-1 isolates from 12 patients with resistance development in the Genvoya group, the mutations that emerged were M184V/I (n = 11) and K65R/N (n = 2) in RT and T66T/A/I/V (n = 2), E92Q (n = 4), Q148Q/R (n = 1) and N155H (n = 2) in integrase.
Danish: Ud af isolater af hiv 1 fra 12 patienter med resistensudvikling i Genvoya-gruppen var de mutationer, der opstod, M184V/I (n = 11) og K65R/N (n = 2) i RT og T66T/A/I/V (n = 2), E92Q (n = 4), Q148Q/R (n = 1) og
English: Co-administration with Genvoya may result in increased plasma concentrations of the DOAC, which may lead to an increased bleeding risk.
Danish: Samtidig administration af Genvoya kan føre til øgede plasmakoncentrationer af DOAK-præparatet, hvilket kan føre til en øget blødningsrisiko.
English: In Study GS-US-292-1825, the efficacy and safety of Genvoya were evaluated in a single-arm, open-label clinical study in which 55 HIV-1 infected adults with end stage renal disease (eGFRCG < 15 mL/min) on chronic haemodialysis for at least 6 months before switching to Genvoya.
Danish: I studie GS-US-292-1825 blev virkning og sikkerhed af Genvoya evalueret i et ublindet klinisk studie med én behandlingsarm, hvor 55 hiv 1-inficerede voksne med nyresygdom i slutstadiet (eGFRCG < 15 ml/min) i kronisk hæmodialyse i mindst 6 måneder, inden de skiftede til Genvoya.
English: Elderly No dose adjustment of Genvoya is required in elderly patients (see sections 5.1 and 5.2).
Danish: Ældre Dosisjustering af Genvoya er ikke nødvendig hos ældre patienter (se pkt.
English: Ex vivo rabbit studies and in vivo dog studies suggest that cobicistat has a low potential for QT prolongation, and may slightly prolong the PR interval and decrease left ventricular function at concentrations at least 11-fold higher than the human exposure at the recommended 150 mg daily dose.
Danish: Ex vivo-studier af kaniner og in vivo-studier af hunde tyder på, at cobicistat har et lavt potentiale for QT-forlængelse, og kan forlænge PR-intervallet let og reducere den venstre ventrikelfunktion ved koncentrationer, der er mindst 11 gange højere end den humane eksponering ved den anbefalede daglige dosis på 150 mg. I et humant klinisk studie af 35 raske personer blev der udført ekkokardiogrammer ved baseline og efter personerne fik 150 mg cobicistat én gang daglig i mindst 15 dage og de indikerede ingen klinisk signifikant ændring i venstre ventrikelfunktion.
English: It is not known whether cobicistat, emtricitabine, or tenofovir alafenamide are inhibitors of other UGT enzymes.
Danish: Det er ukendt, om cobicistat, emtricitabin eller tenofoviralafenamid er hæmmere af andre UGT-enzymer.
English: cisapride (used to relieve certain stomach problems) St. John's wort (Hypericum perforatum, a herbal remedy used for depression and anxiety) or products that contain it lovastatin, simvastatin (used to lower blood cholesterol) pimozide, lurasidone (used to treat abnormal thoughts or feelings) sildenafil (when used to treat pulmonary arterial hypertension - a lung disease that makes breathing difficult) orally administered midazolam, triazolam (used to help you sleep and/or relieve anxiety)
Danish: dihydroergotamin, ergometrin, ergotamin (anvendes til at behandle migræne hovedpine) cisaprid (anvendes til at lindre visse maveproblemer) perikon (Hypericum perforatum, et naturlægemiddel, der anvendes til depression og angst) eller lægemiddel, der indeholder det lovastatin, simvastatin (anvendes til at sænke kolesterol i blodet) pimozid, lurasidon (anvendes til at behandle unormale tanker og følelser) sildenafil (når det anvendes til at behandle pulmonal arteriel hypertension - en lungesygdom, der gør det vanskeligt at trække vejret) oralt administreret midazolam, triazolam (anvendes til at hjælpe dig med at sove og/eller lindre angst)
English: The mean age was 50 years (range 28-67), 92% of patients were male, 69% were White, 18% were Black, and 10% were Asian.
Danish: Gennemsnitsalderen var 50 år (interval: 28-67), 92 % af patienterne var mænd, 69 % var hvide, 18 % var sorte, og 10 % var asiater.
English: Concentrations of these immunosuppressant agents may be increased when administered with cobicistat.
Danish: Koncentrationer af disse immunosupprimerende midler kan øges ved administration af cobicistat.
English: Mean % change of elvitegravir pharmacokinetic parametersa
Danish: Gennemsnitlig % ændring af farmakokinetiske parametre for elvitegravira
English: The EC50 values for tenofovir alafenamide were in the range of 2.0 to 14.7 nM. Tenofovir alafenamide displayed antiviral activity in cell culture against all HIV-1 groups (M, N, and O), including subtypes A, B, C, D, E, F, and G (EC50 values ranged from 0.10 to 12.0 nM) and showed strain specific activity against HIV-2 (EC50 values ranged from 0.91 to 2.63 nM).
Danish: EC50-værdierne for tenofoviralafenamid var i intervallet fra 2,0 til 14,7 nM. Tenofoviralafenamid viste antiviral aktivitet i cellekultur mod alle hiv 1-grupperne (M, N og O), herunder undertype A, B, C, D, E, F og G (EC50-værdier var i intervallet fra 0,10 til 12,0 nM) og viste stammespecifik aktivitet mod hiv 2 (EC50-værdier var i intervallet fra 0,91 til 2,63 nM).
English: Dose modifications are not necessary when administered in combination with Genvoya.
Danish: Dosismodifikationer er ikke nødvendige ved samtidig administration af Genvoya.
English: Baseline regimen (n = 477)
Danish: (n = 477)
English: Co-administration of rifabutin, a potent CYP3A inducer, may significantly decrease cobicistat and elvitegravir plasma concentrations, which may result in loss of therapeutic effect and development of resistance.
Danish: Samtidig administration af rifabutin, en kraftig CYP3Ainducer, kan reducere plasmakoncentrationerne af cobicistat og elvitegravir signifikant, hvilket kan forårsage svigtende terapeutisk virkning og udvikling af resistens.
English: Do not store the split tablet.
Danish: Delte tabletter må ikke gemmes.
English: Three patients had virologic failure at Week 48; there was no virologic resistance detected to Genvoya.
Danish: Tre patienter havde virologisk svigt ved uge 48.
English: HIV-1 isolates with reduced susceptibility to tenofovir alafenamide express a K65R mutation in HIV-1 RT; in addition, a K70E mutation in HIV-1 RT has been transiently observed.
Danish: Isolater af hiv 1 med nedsat følsomhed for tenofoviralafenamid udtrykker en K65R-mutation i hiv 1 RT.
English: At Week 144, 83.1% (197/237 patients) maintained HIV-1 RNA < 50 copies/mL after switching to Genvoya.
Danish: Ved uge 144 havde 83,1 % (197/237 patienter) stadig hiv 1-rna < 50 kopier/ml, efter de var skiftet til Genvoya.
English: At Week 48, 92% of patients (66/72) maintained HIV-1 RNA < 50 copies/mL after switching to Genvoya.
Danish: Ved uge 48 havde 92 % af patienterne (66/72) stadig hiv-1 RNA < 50 kopier/ml efter skift til Genvoya.
English: ORAL CONTRACEPTIVES Drospirenone/Ethinyloestradiol (3 mg/0.02 mg single dose)/ Cobicistat (150 mg once daily)
Danish: ORALE ANTIKONCEPTIVA Drospirenon/ethinylestradiol (3 mg/0,02 mg enkelt dosis)/cobicistat (150 mg én gang dagligt)
English: In Study GS-US-292-1515, the efficacy and safety of Genvoya were evaluated in an open-label study in HIV-1 infected, virologically suppressed adolescents between the ages of 12 and 18 years, weighing ≥ 35 kg (n = 50).
Danish: I studie GS-US-292-1515 blev virkningen og sikkerheden af Genvoya evalueret i et ublindet studie af hiv 1-inficerede, virologisk supprimerede unge i alderen 12 til 18 år, der vejede ≥ 35 kg (n = 50).
English: Polyvinyl alcohol (E1203) Titanium dioxide (E171) Polyethylene glycol (E1521) Talc (E553b)
Danish: Polyethylenglycol (E1521) Talcum (E553b)
English: Some medicinal products should not be co-administered with Genvoya (see sections 4.3 and 4.5).
Danish: Nogle lægemidler må ikke administreres sammen med Genvoya (se pkt.
English: The mean baseline CD4+ cell count was 697 cells/mm3 (range 79-1,951).
Danish: Gennemsnitlig CD4+ celletal ved baseline var 697 celler/mm3 (interval 79-1.951).
English: Concentrations of pitavastatin may be increased when administered with elvitegravir and cobicistat.
Danish: Koncentrationer af pitavastatin kan øges ved administration af elvitegravir og cobicistat.
English: Orally administered midazolam (2.5 mg single dose)/ Tenofovir alafenamide (25 mg once daily)
Danish: Oralt administreret midazolam (2,5 mg enkeltdosis)/Tenofoviralafenamid (25 mg én gang daglig)
English: The use of Genvoya should be accompanied by the use of effective contraception (see sections 4.4 and 4.5).
Danish: Anvendelsen af Genvoya bør ledsages af anvendelse af sikker kontraception (se pkt.
English: Concentrations of clarithromycin and/or cobicistat may be altered with co-administration of Genvoya.
Danish: Koncentrationer af clarithromycin og/eller cobicistat kan ændres ved samtidig administration af Genvoya.
English: Intravenously administered midazolam (1 mg single dose)/ Tenofovir alafenamide (25 mg once daily)
Danish: Intravenøst administreret midazolam (1 mg enkeltdosis)/Tenofoviralafenamid (25 mg én gang daglig)
English: Changes in measures of bone mineral density
Danish: Ændringer i målinger af knoglemineraltæthed
English: Caution is warranted and clinical monitoring is recommended during the co-administration.
Danish: Der rådes til forsigtighed og klinisk overvågning ved samtidig administration.
English: An improved renal safety profile was maintained through Week 96 in patients who switched to Genvoya compared with those who stayed on a tenofovir disoproxil-containing regimen.
Danish: Patienter, som skiftede til Genvoya, opretholdt en forbedret renal sikkerhedsprofil efter 96 ugers behandling sammenlignet med dem, som forblev på et tenofovirdisoproxil-baseret regime.
English: The mean baseline CD4+ cell count was 664 cells/mm3 (range 126-1,813).
Danish: Det gennemsnitlige CD4+ celletal ved baseline var 664 celler/mm3 (interval 126-1.813).
English: HIV-1 isolates with the K65R mutation have low-level reduced susceptibility to abacavir, emtricitabine, tenofovir, and lamivudine.
Danish: Desuden blev der forbigående observeret en K70E-mutation i hiv 1 RT. Isolater af hiv 1 med K65R-mutation har en lav grad af nedsat følsomhed for abacavir, emtricitabin, tenofovir og lamivudin.
English: Buprenorphine/Naloxone (16/4 to 24/6 mg)/ Elvitegravir (150 mg once daily)/ Cobicistat (150 mg once daily)
Danish: Buprenorphin/Naloxon (16/4 til 24/6 mg)/Elvitegravir (150 mg én gang daglig)/Cobicistat (150 mg én gang daglig)
English: Triazolam is primarily metabolised by CYP3A.
Danish: Triazolam metaboliseres primært af CYP3A.
English: Slovenská republika Gilead Sciences Slovakia s.r.o.
Danish: Gilead Sciences Slovakia s.r.o.
English: Midazolam is primarily metabolised by CYP3A.
Danish: Midazolam metaboliseres primært af CYP3A.
English: Concentrations of ketoconazole and/or cobicistat may increase with co-administration of Genvoya.
Danish: Koncentrationer af ketoconazol og/eller cobicistat kan øges ved samtidig administration af Genvoya.
English: The pharmacokinetics of emtricitabine have not been studied in patients with hepatic impairment; however, emtricitabine is not significantly metabolised by liver enzymes, so the impact of liver impairment should be limited.
Danish: Imidlertid metaboliseres emtricitabin ikke signifikant af leverenzymer, så påvirkningen af nedsat leverfunktion bør være begrænset.
English: At Week 48, 81.8% (45/55 patients) maintained HIV-1 RNA < 50 copies/mL after switching to Genvoya.
Danish: Ved uge 48 havde 81,8 % (45/55 patienter) stadig hiv 1-rna < 50 kopier/ml, efter de var skiftet til Genvoya.
English: In Study GS-US-292-0106, the efficacy, safety, and pharmacokinetics of Genvoya were evaluated in an open-label study in HIV-1 infected, treatment-naïve adolescents between the ages of 12 to < 18 years, weighing ≥ 35 kg (n = 50) in Cohort 1, and in virologically suppressed children between the ages of 8 to < 12 years, weighing > 25 kg (n = 23) in Cohort 2.
Danish: I studie GS-US-292-0106 blev virkningen, sikkerheden og farmakokinetikken af Genvoya evalueret i et ublindet studie af hiv 1-inficerede, behandlingsnaive unge i alderen 12 til < 18 år, der vejede ≥ 35 kg (n = 50) i kohorte 1, og hos virologisk supprimerede børn i alderen 8 til < 12 år, der vejede > 25 kg (n = 23) i kohorte 2.
English: Ketoconazole (200 mg twice daily)/ Elvitegravir (150 mg once daily)2
Danish: Ketoconazol (200 mg to gange daglig)/Elvitegravir (150 mg én gang daglig)2
English: At baseline, median CD4+ cell count was 969 cells/mm3 (range: 603 to 1,421), and median CD4+% was 39% (range: 30 to 51%).
Danish: Ved baseline, var median CD4+ celletal 969 celler/mm3 (interval: 603 til 1421), og median C4+ % var 39 % (interval: 30 til 51 %).
English: No dose adjustment of sofosbuvir/velpatasvir/voxilaprevir and Genvoya is warranted upon co-administration.
Danish: Dosisjustering af sofosbuvir/velpatasvir/voxilaprevir og Genvoya er ikke nødvendig ved samtidig administration.
English:  If you are taking any of these medicines, do not take Genvoya and tell your doctor immediately.
Danish:  Hvis De tager nogen af disse lægemidler, må De ikke tage Genvoya.
English: The mean change from baseline in CD4+ cell count and percentage at Week 48 was -90 cells/mm3 and -1.3%, respectively.
Danish: Gennemsnitsændringen fra baseline i CD4+ celletal og procentdel ved 48 uger var henholdsvis -90 celler/mm3 og -1,3 %.
English: Concentrations of telithromycin and/or cobicistat may be altered with co-administration of Genvoya.
Danish: Koncentrationer af telithromycin og/eller cobicistat kan ændres ved samtidig administration af Genvoya.
English: No clinically relevant differences in elvitegravir or cobicistat pharmacokinetics were observed between patients with moderate hepatic impairment and subjects with normal hepatic function.
Danish: Der blev ikke observeret nogen klinisk relevante forskelle i farmakokinetikken for elvitegravir eller cobicistat hos patienter med moderat nedsat leverfunktion og hos personer med normal leverfunktion.
English: At baseline, median CD4+ cell count was 742 cells/mm3 (range: 255 to 1,246) and median CD4+% was 34% (range: 21 to 53%).
Danish: Ved baseline var median CD4+ celletal 742 celler/mm3 (interval: 255 til 1246) og median CD4+ % var 34 % (interval: 21 til 53 %).
English: • tenofovir alafenamide, an antiretroviral medicine known as a nucleotide reverse transcriptase inhibitor (NtRTI)
Danish: • tenofoviralafenamid, et antiretroviralt lægemiddel, der kaldes en nukleotid-revers transkriptase-hæmmer (NtRTI)
English: TAFb TFVb EVGe COBIe FTCe TAFf
Danish: FTCa TAFb TFVb
English: Co-administration of Genvoya and lovastatin and simvastatin is contraindicated (see section 4.3).
Danish: Samtidig administration af Genvoya og lovastatin og simvastatin er kontraindiceret (se pkt.
English: In open-label Study GS-US-292-1249, the efficacy and safety of Genvoya were evaluated in adult patients co-infected with HIV-1 and chronic hepatitis B. Sixty-nine of the 72 patients were on prior tenofovir disoproxil-containing antiretroviral therapy.
Danish: Sikkerheden og virkningen af Genvoya blev evalueret i det ublindede studie GS-US-292-1249 hos voksne patienter med samtidig infektion med hiv-1 og kronisk hepatitis B. 69 ud af de 72 patienter havde tidligere fået tenofovirdisoproxil-baseret antiretroviral behandling.
English: NARCOTIC ANALGESICS Methadone (80-120 mg)/ Elvitegravir (150 mg once daily)/ Cobicistat (150 mg once daily)
Danish: NARKOTISKE ANALGETIKA Methadon (80-120 mg)/Elvitegravir (150 mg én gang daglig)/Cobicistat (150 mg én gang daglig)
English: No dose adjustment of ledipasvir/sofosbuvir and Genvoya is warranted upon co-administration.
Danish: Dosisjustering af ledipasvir/sofosbuvir og Genvoya er ikke nødvendig ved samtidig administration.