FrancophonIA/ELRC3.0 huggingface dataset:
English: In clinical trials of HBV infected patients, the most frequently occurring adverse reaction to tenofovir disoproxil was nausea (5.4%).
Croatian: U kliničkim ispitivanjima s bolesnicima zaraženima HBV-om, najčešće zabilježena nuspojava na tenofovirdizoproksil bila je mučnina (5,4%).
English: • That Viread may cause a reduction in BMD and the effects of Viread associated changes in BMD on long term bone health and future fracture risk are currently unknown in paediatric patients
Croatian: • Da Viread može prouzročiti smanjenje BMD-a i da učinci Vireada povezani s promjenama u BMD-u na dugotrajno zdravlje kostiju i budući rizik od prijeloma u pedijatrijskih bolesnika trenutno nisu poznati.
English: Look out for signs of inflammation or infection soon after your child starts taking Viread.
Croatian: Obratite pozornost na znakove upale ili infekcije ubrzo nakon što Vaše dijete započne uzimati Viread.
English: Your child can also pass on HIV or HBV to others, so it is important to take precautions to avoid infecting other people.
Croatian: Vaše dijete isto tako može prenijeti HIV ili HBV na druge, pa je zbog toga važno poduzeti mjere opreza kako bi se izbjeglo inficiranje drugih osoba.
English: • For ½ scoop: • Fill the dosing scoop up to the “½ line” on the side (see Figure C).
Croatian: • Za ½ mjerne žličice: • Napunite mjernu žličicu do oznake “½” s vanjske strane (pogledajte sliku C).
English: Although these doses are not expected to exactly reproduce the pharmacokinetic profile of tenofovir in patients with normal renal function receiving tenofovir disoproxil 245 mg film-coated tablets, they are considered to represent the best balance of benefit and risk for patients with renal impairment.
Croatian: Iako se ne očekuje da će te doze točno reproducirati farmakokinetički profil tenofovira u bolesnika s normalnom funkcijom bubrega koji primaju tenofovirdizoproksil 245 mg filmom obloženih tableta, one predstavljaju nabolju ravnotežu koristi i rizika za bolesnike s oštećenjem bubrega.
English: • increased creatinine in your child's blood
Croatian: • povišenu razinu kreatinina u krvi Vašeg djeteta
English: Viread may affect your child's kidneys during treatment.
Croatian: Viread može utjecati na bubrege Vašeg djeteta tijekom liječenja.
English: • breakdown of muscle, muscle pain or weakness
Croatian: • oštećenje mišića, bol ili slabost u mišićima
English: There were no clinically significant pharmacokinetic interactions when tenofovir disoproxil was co-administered with emtricitabine, lamivudine, indinavir, efavirenz, nelfinavir, saquinavir (ritonavir boosted), methadone, ribavirin, rifampicin, tacrolimus, or the hormonal contraceptive norgestimate/ethinyl oestradiol.
Croatian: Nema klinički značajnih farmakokinetičkih interakcija kada se tenofovirdizoproksil primjenjuje istovremeno s emtricitabinom, lamivudinom, indinavirom, efavirenzom, nelfinavirom, sakvinavirom (pojačanim ritonavirom), metadonom, ribavirinom, rifampicinom, takrolimusom ili hormonskim kontraceptivom norgestimatom/etinil estradiolom.
English: These pharmacokinetic modelling data have not been confirmed in clinical studies.
Croatian: Ti modeli podataka o farmakokinetici nisu potvrđeni u kliničkim ispitivanjima.
English: • non-steroidal anti-inflammatory drugs (NSAIDs, to relieve bone or muscle pains).
Croatian: • nesteroidne antiinflamatorne (protuupalne) lijekove (NSAIL, za ublažavanje boli u kostima ili mišićima)
English: Flares after treatment discontinuation: Acute exacerbation of hepatitis has also been reported in patients who have discontinued hepatitis B therapy.
Croatian: Reaktivacija bolesti nakon prekida liječenja: Akutna egzacerbacija hepatitisa također je zabilježena u bolesnika koji su prekinuli terapiju hepatitisa B.
English: Moreover, at concentrations substantially higher (approximately 300-fold) than those observed in vivo, tenofovir did not inhibit in vitro drug metabolism mediated by any of the major human CYP450 isoforms involved in drug biotransformation (CYP3A4, CYP2D6, CYP2C9,
Croatian: Štoviše, u koncentracijama koje su znatno više (približno 300 puta) od onih koje su zapažene in vivo tenofovir nije inhibirao in vitro metabolizam lijekova koji se odvija posredstvom bilo kojeg od glavnih humanih izooblika CYP450 uključenih u biotransformaciju lijekova (CYP3A4, CYP2D6,
English: Pharmacokinetic studies have not been performed in children under 2 years.
Croatian: Farmakokinetička ispitivanja nisu provedena u djece mlađe od 2 godine.
English: Use with certain hepatitis C virus antiviral agents
Croatian: Primjena s određenim antivirusnim lijekovima protiv virusa hepatitisa C
English: Refer to Table 1.
Croatian: Vidjeti tablicu 1.
English: • That patients should have their baseline renal function assessed prior to initiating Viread therapy
Croatian: • Da bolesnicima treba odrediti osnovnu funkciju bubrega prije početka terapije Vireadom
English: • If your child becomes pregnant, ask your child's doctor about the potential benefits and risks of the antiretroviral therapy to your child and your child's baby.
Croatian: • Ako Vaše dijete zatrudni obratite se liječniku Vašeg djeteta koji će vam objasniti koje su moguće koristi i rizici od antiretrovirusne terapije za Vaše dijete i dijete Vašeg djeteta.
English: • You must mix the granules with soft food which does not require chewing, for example yoghurt,
Croatian: • Granule morate promiješati s mekanom hranom koju nije potrebno žvakati, na primjer,
English: • If you are allergic to tenofovir, tenofovir disoproxil or any of the other ingredients of this medicine listed in section 6.
Croatian: • ako ste alergični na tenofovir, tenofovirdizoproksil ili neki drugi sastojak ovog lijeka naveden u dijelu 6.
English: Viread has not been studied in patients over 65 years of age.
Croatian: Viread nije ispitan u bolesnika starijih od 65 godina.
English: Viread granules contain mannitol which may have a mild laxative effect.
Croatian: Viread granule sadrže manitol, koji može imati blagi laksativni učinak.
English: Of the 94 patients with cirrhosis at baseline (Ishak fibrosis score: 5 - 6), 26% (24) experienced no change in Ishak fibrosis score and 72% (68) experienced regression of cirrhosis by week 240 with a reduction in Ishak fibrosis score of at least 2 points.
Croatian: Od 94 bolesnika s cirozom na početku (5-6 bodova na Ishakovoj ljestvici fibroze), 26% (24) nije imalo nikakve promjene u rezultatu na Ishakovoj ljestvici fibroze, a 72% (68) je imalo regresiju ciroze do 240. tjedna i snižen rezultat na Ishakovoj ljestvici fibroze za najmanje 2 boda.
English: • If your child is allergic to tenofovir, tenofovir disoproxil or any of the other ingredients of this medicine listed in section 6.
Croatian: • ako je Vaše dijete alergično na tenofovir, tenofovirdizoproksil ili neki drugi sastojak ovog lijeka naveden u dijelu 6.
English: Please refer to the Summaries of Product Characteristics for Viread 33 mg/g granules and Viread 123 mg, 163 mg and 204 mg film-coated tablets.
Croatian: Molimo pročitajte sažetke opisa svojstava lijeka za Viread 33 mg/g granule i Viread 123 mg, 163 mg i 204 mg filmom obložene tablete.
English: ALT elevations had a median time to onset of 8 weeks, resolved with continued treatment, and, in a majority of cases, were associated with a ≥ 2 log10 copies/ml reduction in viral load that preceded or coincided with the ALT elevation.
Croatian: Medijan vremena do pojave povišene razine ALT-a iznosio je 8 tjedana, a povukla se s nastavkom liječenja i u većini slučajeva bila povezana sa smanjenjem virusnog opterećenja za ≥ 2 log10 kopija/ml koje je prethodilo ili se podudaralo s povišenjem razine ALT-a.
English: If you are older than this and are prescribed Viread, your doctor will monitor you carefully.
Croatian: Imate li više od 65 godina, a propisali su Vam Viread, liječnik će Vas pažljivo nadzirati.
English: Viread does not reduce the risk of passing on HBV to others through sexual contact or blood contamination.
Croatian: Viread ne smanjuje rizik od prijenosa HBV-a na druge osobe spolnim putem ili putem krvi.
English: Discuss with your child's doctor the precautions needed to avoid infecting other people.
Croatian: Razgovarajte s liječnikom Vašeg djeteta o mjerama opreza koje treba poduzeti da se druge osobe ne bi zarazile.
English: • It is very important to tell your child's doctor if your child is taking other medicines that may damage their kidneys.
Croatian: • Vrlo je važno da liječnika Vašeg djeteta obavijestite ako Vaše dijete uzima druge lijekove koji mu mogu oštetiti bubrege.
English: Viread is not usually taken with other medicines that can damage your child's kidneys (see Other medicines and Viread).
Croatian: Viread se obično ne uzima s drugim lijekovima koji mogu oštetiti bubrege Vašeg djeteta (pogledajte Drugi lijekovi i Viread).
English: • children aged 6 to less than 12 years
Croatian: • djece u dobi od 6 do manje od 12 godina
English: Tell your child's doctor or pharmacist if they are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite liječnika Vašeg djeteta ili ljekarnika ako Vaše dijete uzima ili je nedavno uzelo ili bi moglo uzeti bilo koje druge lijekove.
English: If Viread is used with nephrotoxic medicinal products, renal function should be closely monitored according to the recommended schedule
Croatian: Ako se Viread primjenjuje s nefrotoksičnim lijekovima, bubrežnu funkciju treba pažljivo nadzirati prema preporučenom rasporedu.
English: Please refer to the Summaries of Product Characteristics for these medicinal products.
Croatian: Molimo vidjeti sažetke opisa svojstava lijeka za te lijekove.
English: In addition to the opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also occur after your child starts taking medicines for the treatment of their HIV infection.
Croatian: Pored oportunističkih infekcija, autoimuni poremećaji (stanje koje se javlja kada imunološki sustav napada zdravo tkivo Vašeg organizma) mogu se također dogoditi kada Vaše dijete počne uzimati lijekove za liječenje infekcije HIV-om.
English: As a general rule, it is recommended that HIV infected women do not breast-feed their infants in order to avoid transmission of HIV to the infant.
Croatian: Kao opće pravilo, preporučuje se da žene inficirane HIV-om ne doje svoju dojenčad, kako bi se izbjegao prijenos virusa HIV-a na dojenče.
English: In patients with moderate or severe renal impairment (creatinine clearance < 50 ml/min) the daily dose must be adjusted and renal function should be closely monitored (see sections 4.2 and 5.2).
Croatian: U bolesnika s umjerenim ili teškim oštećenjem funkcije bubrega (klirens kreatinina < 50 ml/min) dnevna doza mora se prilagoditi, a funkcija bubrega detaljno pratiti (vidjeti dijelove 4.2 i 5.2).
English: • Your child must not breast-feed, to avoid passing the virus to the baby in breast milk.
Croatian: • Vaše dijete ne smije dojiti kako bi se izbjegla mogućnost da virus u majčinom mlijeku prijeđe na dojenče.
English: • Use the flat edge of clean knife to make the granules even with the top of the scoop (see Figure B).
Croatian: • Pomoću ravnog ruba čistog noža poravnajte granule s gornjim rubom mjerne žličice (pogledajte sliku B).
English:  If this applies to your child, tell their doctor immediately and don't give Viread.
Croatian: Ako se ovo odnosi na Vaše dijete, odmah o tome obavijestite liječnika Vašeg djeteta i nemojte mu dati Viread.
English: If your child feels dizzy while taking Viread, they must not drive or ride a bicycle and must not use any tools or machines.
Croatian: Ako Vaše dijete tijekom uzimanja Vireada ima omaglicu, ne smije upravljati vozilom, voziti se na biciklu niti raditi s alatima ili na strojevima.
English: Your child must always take this medicine exactly as their doctor or pharmacist has told you.
Croatian: Vaše dijete mora uvijek uzimati ovaj lijek točno onako kako Vam je rekao njegov liječnik ili ljekarnik.
English: Cmax (μg/ml) AUCtau (μg·h/ml)
Croatian: Cmax (μg/ml)
English: It is important not to miss a dose of Viread.
Croatian: Važno je da ne propustite uzeti dozu Vireada.
English: If you feel dizzy while taking Viread, do not drive or ride a bicycle and do not use any tools or machines.
Croatian: Ako tijekom uzimanja Vireada imate omaglicu, nemojte upravljati vozilom, voziti se na biciklu niti raditi s alatima ili na strojevima.
English: • breakdown of muscle, muscle pain or weakness Tests may also show:
Croatian: • oštećenje mišića, bol ili slabost u mišićima Pretrage mogu također pokazati:
English: • adults
Croatian: Odrasli
English: Refer to section 2 “Viread granules contain mannitol”.
Croatian: Pogledajte dio 2 „Viread granule sadrže manitol”.
English: (11 subjects)
Croatian: (11 bolesnika)
English: [Outer packaging only]
Croatian: [Samo na vanjskom pakiranju]
English: 0.38 ± 0.13 μg/ml and 3.39 ± 1.22 μg·h/ml, respectively.
Croatian: (±SD) Cmax iznosi 0,38 ± 0,13 μg/ml, a AUCtau 3,39 ± 1,22 μg·h/ml.
English: • Talk to your doctor before you stop taking Viread for any reason, particularly if you are experiencing any side effects or you have another illness.
Croatian: • Razgovarajte s liječnikom prije nego što iz bilo kojeg razloga prestanete uzimati Viread, osobito ako osjetite neke nuspojave ili dobijete neku drugu bolest.
English: If a patient misses a dose of Viread by more than 12 hours and it is almost time for their next dose, the patient should not take the missed dose and simply resume the usual dosing schedule.
Croatian: Ako bolesnik propusti uzeti dozu Vireada a prošlo je više od 12 sati i već je blizu vrijeme za uzimanje sljedeće doze, bolesnik ne treba uzeti propuštenu dozu nego jednostavno nastaviti uzimati lijek prema svom uobičajenom rasporedu.
English: Complete response (%)
Croatian: Potpuni odgovor (%)a
English: If this is unavoidable, your doctor will monitor your kidney function once a week.
Croatian: Ako se to ne može izbjeći, liječnik će jednom tjedno pratiti funkciju
English: Look out for signs of inflammation or infection soon after you start taking Viread.
Croatian: Obratite pozornost na znakove upale ili infekcije ubrzo nakon što započnete uzimati Viread.
English: Read all of this leaflet carefully before your child starts taking this medicine because it contains important information for you.
Croatian: Pažljivo pročitajte cijelu uputu prije nego što Vaše dijete počne uzimati ovaj lijek jer sadrži
English: Doses of 132 mg, 65 mg and 33 mg tenofovir disoproxil granules once daily are recommended in adult patients with calculated creatinine clearance (CrCl) of 30 to 49 ml/min, 20 to 29 ml/min or 10 to 19 ml/min, respectively.
Croatian: Doze od 132 mg, 65 mg i 33 mg granula tenofovirdizoproksila jedanput na dan preporučuju se u odraslih bolesnika s izračunatim klirensom kreatinina (CrCl) od 30 do 49 ml/min, 20 do 29 ml/min, odnosno 10 do 19 ml/min.
English: 2 This adverse reaction was identified through post-marketing surveillance but not observed in randomised controlled clinical trials or the tenofovir disoproxil expanded access program.
Croatian: Ova nuspojava prepoznata je tijekom praćenja lijeka nakon stavljanja u promet, ali nije opažena u randomiziranim kliničkim kontroliranim ispitivanjima tenofovirdizoproksila ili programu proširenog pristupa terapiji.
English: If you notice any of these symptoms tell your child's doctor.
Croatian: Ako opazite bilo koji od tih simptoma, obavijestite liječnika Vašeg djeteta.
English: Don't stop taking Viread without your doctor's advice.
Croatian: Nemojte prestati uzimati Viread bez liječničke preporuke.
English: • If it is more than 12 hours since your child should have taken it, forget about the missed dose.
Croatian: • Ako je proteklo više od 12 sati od vremena kada ju je Vaše dijete trebalo uzeti, zaboravite na dozu koju je propustilo.
English: Do not take Viread
Croatian: Nemojte uzimati Viread
English: Haemodialysis patients: 16.5 mg (0.5 scoop) tenofovir disoproxil 33 mg/g granules may be administered following completion of each 4-hour haemodialysis session.
Croatian: Bolesnici na hemodijalizi: 16,5 mg (0,5 mjerne žličice) tenofovirdizoproksila 33 mg/g granula, može se primijeniti nakon završetka svakog postupka hemodijalize od 4 sata.
English: Tenofovir diphosphate inhibits HIV-1 reverse transcriptase and the HBV polymerase by direct binding competition with the natural deoxyribonucleotide substrate and, after incorporation into DNA, by DNA chain termination.
Croatian: Tenofovirdifosfat inhibira reverznu transkriptazu virusa HIV-1 i polimerazu virusa HBV izravno se natječući za vezno mjesto s prirodnim deoksiribonukleotidnim supstratom i, nakon ugradnje u DNK, završetkom DNK lanca.
English: Tolerability failure (permanent discontinuation of study drug due to a treatment emergent AE) n (%)a
Croatian: Neuspjeh podnošljivosti (trajni prekid ispitivanja lijeka zbog nuspojave) n (%)a
English: All adverse reactions are presented in Table 3.
Croatian: Sve su nuspojave prikazane u tablici 3.
English: Viruses containing the rtA181T mutation remained susceptible to tenofovir with EC50 values 1.5-fold that of wild-type virus.
Croatian: Virusi koji sadrže mutaciju rtA181T ostali su osjetljivi na tenofovir s vrijednostima EC50 1,5 puta višim od onih divljeg tipa virusa.
English: How to take Viread
Croatian: Kako uzimati Viread
English: Viread can cause dizziness.
Croatian: Viread može uzrokovati omaglicu.
English: Cmin: N/A Velpatasvir:
Croatian: Cmin: NP Velpatasvir:
English: Do not change the dose unless your child's doctor tells you to.
Croatian: Nemojte mijenjati dozu, osim ako Vam liječnik Vašeg djeteta ne kaže da to učinite.
English: Your child must not stop taking Viread without their doctor's advice.
Croatian: Vaše dijete ne smije prestati uzimati Viread bez liječničke preporuke.
English: Your child may require blood tests for several months after stopping treatment.
Croatian: Možda će Vaše dijete morati nekoliko mjeseci nakon prestanka liječenja raditi krvne pretrage.
English: applesauce or baby food.
Croatian: jogurtom, pireom od jabuka ili dječjom hranom).
English: Dose and formulation
Croatian: Doza i oblik
English: What you need to know before you take Viread
Croatian: Što morate znati prije nego počnete uzimati Viread
English: If your child forgets to take Viread
Croatian: Ako je Vaše dijete zaboravilo uzeti Viread
English: 90 (3 bottles of 30) tablets.
Croatian: 90 (3 boce od 30) filmom obloženih tableta. 90 (3 boce od 30) tableta.
English: Serum ALT and HBV DNA levels should be followed regularly after treatment discontinuation to detect any late virological relapse.
Croatian: HBV DNK moraju se redovito nadzirati nakon prestanka liječenja, kako bi se uočio svaki kasni virološki relaps.
English: p-value = 0.0008).
Croatian: (p < 0,0001).
English: In patients with compensated liver disease, these increases in serum ALT are generally not accompanied by an increase in serum bilirubin concentrations or hepatic decompensation.
Croatian: bolesnika s kompenziranom bolešću jetre ovi porasti razine serumskog ALT-a obično nisu popraćeni porastom serumske koncentracije bilirubina ili dekompenzacijom jetre.
English: Interrupting treatment with Viread should also be considered in case of progressive decline of renal function when no other cause has been identified.
Croatian: Prekid liječenja Vireadom također treba razmotriti u slučaju progresivnog slabljenja funkcije bubrega ako se nije utvrdio niti jedan drugi uzrok
English: If your child has hepatitis B infection, your child's doctor will carefully consider the best treatment for them.
Croatian: Ako je Vaše dijete zaraženo hepatitisom B, liječnik Vašeg djeteta pažljivo će razmisliti o najboljem liječenju za Vaše dijete.
English: PC: {number} SN: {number} NN: {number} [Outer packaging only]
Croatian: NN: {broj} [Samo na vanjskom pakiranju]
English: a The population used for analysis of histology included only patients with available liver biopsy data (Missing = Excluded)
Croatian: a Populacija koja se koristila za histološku analizu uključila je samo bolesnike s dostupnim podacima za biopsiju jetre (podaci nedostaju = isključeni) do 240. tjedna.
English: Co-administration and risk of renal toxicity The same recommendations apply as in adults (see above).
Croatian: Vrijede iste preporuke kao i za odrasle (vidjeti gore).
English: Viread granules should be mixed in a container with soft food not requiring chewing, for example yoghurt, applesauce or baby food.
Croatian: Viread granule potrebno je promiješati u posudi s mekanom hranom koju nije potrebno žvakati, na primjer, jogurtom, pireom od jabuka ili dječjom hranom.
English: Viread is not usually taken with other medicines that can damage your kidneys (see Other medicines and Viread).
Croatian: Viread se obično ne uzima s drugim lijekovima koji Vam mogu oštetiti bubrege (pogledajte Drugi lijekovi i Viread).
English: • Other medicines containing didanosine (for HIV infection): Taking Viread with other antiviral medicines that contain didanosine can raise the levels of didanosine in the blood and may reduce CD4 cell counts.
Croatian: • Drugi lijekovi koji sadrže didanozin (za infekciju virusom HIV-a): Uzimanje Vireada s drugim antivirusnim lijekovima koji sadrže didanozin može povećati razinu didanozina u krvi i smanjiti broj CD4 stanica.
English: This dosing recommendation balances the need to limit drug accumulation while attempting to maintain sufficient tenofovir concentrations over the dosing interval similar to trough concentrations observed in patients with normal renal function receiving tenofovir disoproxil 245 mg film-coated tablets.
Croatian: Ta preporuka doziranja uravnotežuje potrebu za ograničavanje akumulacije lijeka, održavajući dostatne koncentracije tenofovira u intervalu između doza slične najnižim koncentracijama zapaženih u bolesnika s normalnom funkcijom bubrega koji primaju tenofovirdizoproksil 245 mg filmom obloženih tableta.
English: Deutschland Gilead Sciences GmbH Tel: + 49 (0) 89 899890-0
Croatian: Gilead Sciences GmbH Tel: + 49 (0) 89 899890-0
English: Overall, the data derived from this study are too limited to draw any definitive conclusions on the comparison of emtricitabine plus tenofovir disoproxil versus tenofovir disoproxil, (see Table 8 below).
Croatian: Ukupno gledano, podaci dobiveni iz ovog ispitivanja previše su ograničeni da bi se iz njih mogao izvući konačni zaključak o usporedbi emtricitabina u kombinaciji s tenofovirdizoproksilom nasuprot tenofovirdizoproksila (vidjeti tablicu 8 niže).
English: If you notice that your child has any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your child's doctor immediately to seek necessary treatment.
Croatian: Ako kod Vašeg djeteta uočite bilo koje simptome infekcije ili druge simptome poput slabosti mišića, slabosti koja počinje u šakama i stopalima i pomiče se nagore prema trupu tijela, osjećaja lupanja srca, nevoljnog drhtanja ili hiperaktivnosti, obavijestite liječnika svog djeteta odmah kako biste potražili liječničku pomoć.
English: Tenofovir diphosphate has an intracellular half-life of 10 hours in activated and 50 hours in resting peripheral blood mononuclear cells (PBMCs).
Croatian: Tenofovirdifosfat ima unutarstanični poluživot od 10 sati u aktiviranim mononuklearnim stanicama periferne krvi (MSPK) i 50 sati u mirujućim MSPK.
English: • Talk to your child's doctor or pharmacist if your child has had kidney disease or if tests have shown problems with their kidneys.
Croatian: • Obavijestite liječnika Vašeg djeteta ili ljekarnika ako je Vaše dijete imalo bolest bubrega ili ako su testovi ukazivali na probleme s bubrezima.
English: Findings in the rat and monkey studies indicated that there was a substancerelated decrease in intestinal absorption of phosphate with potential secondary reduction in BMD.
Croatian: Nalazi dobiveni ispitivanjima na štakorima i majmunima pokazali su da postoji smanjenje intestinalne apsorpcije fosfata, koje je bilo povezano s djelatnom tvari, uz potencijalno sekundarno smanjenje mineralne gustoće kostiju.