FrancophonIA/ELRC3.0 huggingface dataset:
English: Adverse reactions are presented in the order of decreasing seriousness and their frequency is defined as follows: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to
Danish: Bivirkningerne er præsenteret i rækkefølge efter faldende alvorlighed, og deres frekvens er defineret på følgende måde: meget almindelig (≥1/10); almindelig (≥1/100 til <1/10); ikke almindelig (≥1/1.000 til <1/100); sjælden (≥1/10.000 til <1/1.000) og meget sjælden (<1/10.000).
English: • symptoms such as low urine volume, tiredness, nausea, vomiting, confusion and swelling in the legs, ankles or feet, as this may be a sign of sudden decrease of kidney function
Danish: • symptomer, såsom nedsat urinmængde, træthed, kvalme, opkastning, forvirring og hævelse af benene, anklerne eller fødderne, da disse kan være tegn på pludseligt nedsat nyrefunktion
English: The administration of levetiracetam to patients with renal impairment may require dose adjustment.
Danish: Anvendelse af Levetiracetam Teva til patienter med nedsat nyrefunktion kan kræve dosisjustering.
English: This binding site is the synaptic vesicle protein 2A, believed to be involved in vesicle fusion and neurotransmitter exocytosis.
Danish: Dette bindingssted er det synaptiske vesikelprotein 2A, som formodes at være involveret i vesikelfusion og exocytose af neurotransmittere.
English: For children with renal impairment, levetiracetam dose needs to be adjusted based on the renal function as levetiracetam clearance is related to renal function.
Danish: Hos børn med nedsat nyrefunktion skal levetiracetam dosis justeres i forhold til nyrefunktionen, da levetiracetamclearance er afhængigt af nyrefunktionen.
English: Pre-marketing data from clinical studies conducted in adults indicate that levetiracetam did not influence the serum concentrations of existing antiepileptic medicinal products (phenytoin, carbamazepine, valproic acid, phenobarbital, lamotrigine, gabapentin and primidone) and that these antiepileptic medicinal products did not influence the pharmacokinetics of levetiracetam.
Danish: Data fra kliniske studier før markedsføring med voksne tyder på, at Levetiracetam Teva ikke påvirker serumkoncentrationerne af eksisterende antiepileptika (phenytoin, carbamazepin, valproat, phenobarbital, lamotrigin, gabapentin og primidon), og at disse antiepileptika ikke påvirker levetiracetams farmakokinetik.
English: Levetiracetam is excreted in human breast milk.
Danish: Levetiracetam udskilles i human brystmælk.
English: Complete blood cell counts are advised in patients experiencing important weakness, pyrexia, recurrent infections or coagulation disorders (section 4.8).
Danish: Det anbefales at foretage en komplet blodtælling hos patienter, som oplever betydelig svækkelse, pyreksi, tilbagevendende infektioner eller koagulationsforstyrrelser (se pkt.
English: There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetam.
Danish: Der foreligger enkeltstående indberetninger om nedsat virkning af levetiractam i tilfælde, hvor osmotisk afførende macrogol blev administreret samtidig med oral levetiracetam.
English: TEVA UK Ltd Brampton Road Hampden Park Eastbourne, East Sussex BN22 9AG UK United Kingdom
Danish: TEVA UK Ltd Brampton Road Hampden Park Eastbourne, East Sussex BN22 9AG UK Storbritannien
English: A meta-analysis of randomized placebo-controlled trials of anti-epileptic medicinal products has shown a small increased risk of suicidal thoughts and behaviour.
Danish: En metaanalyse af randomiserede, placebokontrollerede studier med antiepileptika har vist en let øget risiko for selvmordstanker og -adfærd.
English: Depending upon the clinical response and tolerability, the daily dose can be increased up to 1500 mg twice daily.
Danish: Afhængigt af klinisk virkning og tolerabilitet kan den daglige dosis øges til 1.500 mg to gange daglig.
English: Swallow Levetiracetam Teva tablets with a sufficient quantity of liquid (e.g. a glass of water).
Danish: Levetiracetam Teva tabletter synkes med rigelig væske (f.eks. et glas vand).
English: Take the number of tablets following your doctor's instructions.
Danish: Tag det antal tabletter, som lægen har ordineret.
English: • swelling of the face, lips, tongue and throat (Quincke's oedema)
Danish: • hævelse af ansigt, læber, tunge eller svælg (Quinckes ødem)
English: Do not use this medicine after the expiry date stated on the carton box and blister after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på æsken og blisteren efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: If levetiracetam has to be discontinued it is recommended to withdraw it gradually (e.g. in adults and adolescents weighing more than 50 kg: 500 mg decreases twice daily every two to four weeks; in infants older than 6 months, children and adolescents weighting less than 50 kg: dose decrease should not exceed 10 mg/kg twice daily every two weeks; in infants (less than 6 months): dose decrease should not exceed 7 mg/kg twice daily every two weeks).
Danish: Hvis behandlingen med levetiracetam skal afbrydes, anbefales det at seponere gradvist (f.eks. for voksne og unge, som vejer mere end 50 kg: reduktion med 500 mg to gange dagligt hver anden til fjerde uge; for spædbørn over 6 måneder, børn og unge, som vejer under 50 kg: dosis bør ikke reduceres med mere end 10 mg/kg to gange dagligt hver anden uge; for spædbørn (under 6 måneder): dosis bør ikke reduceres med mere end 7 mg/kg to gange dagligt hver anden uge).
English: The dose can be further increased by 250 mg twice daily every two weeks depending upon the clinical response.
Danish: Dosis kan øges med yderligere 250 mg to gange daglig hver anden uge afhængigt af den kliniske virkning.
English: The tablet formulation is not adapted for use in infants and children under the age of 6 years.
Danish: Tabletformuleringen er ikke egnet til brug hos spædbørn og børn under 6 år.
English: Nervous system disorders
Danish: Nervesystemet Døsighed,
English: Weight decreased, weight increase
Danish: Vægttab, vægtstigning
English: The patients were randomized to carbamazepine CR 400 - 1200 mg/day or levetiracetam 1000 - 3000 mg/day, the duration of the treatment was up to 121 weeks depending on the response.
Danish: Patienterne blev randomiseret til carbamazepin CR 400-1.200 mg/dag eller levetiracetam 1.000-3.000 mg/dag, varigheden af behandlingen var op til 121 uger afhængigt af respons.
English: Add-on therapy for infants aged from 1 month to less than 6 months
Danish: Tillægsbehandling til spædbørn i alderen fra 1 måned til under 6 måneder
English: • Levetiracetam Teva is used as a chronic treatment.
Danish: • Levetiracetam Teva anvendes til kronisk behandling.
English: In vitro, levetiracetam and its primary metabolite have been shown not to inhibit the major human liver cytochrome P450 isoforms (CYP3A4, 2A6, 2C9, 2C19, 2D6, 2E1 and 1A2), glucuronyl transferase (UGT1A1 AND UGT1A6) and epoxide hydroxylase activities.
Danish: In vitro studier viste, at levetiracetam og dets primære metabolit ikke hæmmer de vigtigste human lever cytochrom P450 isoformer (CYP3A4, 2A6, 2C9, 2C19, 2D6, 2E1 og 1A2), glucuronyltransferase (UGT1A1 og UGT1A6) og epoxid hydroxylase aktiviteter.
English: You should not drive or use machines until it is established that your ability to perform such activities is not affected.
Danish: Du må ikke køre bil, motorcykel, cykle eller anvende maskiner, før du er helt sikker på, at din evne til at udføre sådanne aktiviteter ikke er påvirket.
English: An oral solution is a formulation more appropriate to infants and children under the age of 6 years and to children and adolescent (from 6 to 17 years) weighing less than 50 kg and when tablets don't allow accurate dosage.
Danish: En oral opløsning er den best egnede lægemiddelformulering til spædbørn og børn under 6 år og til børn og unge (fra 6 til 17 år), som vejer mindre end 50 kg, og hvor tabletter ikke muliggøre nøjagtig dosis.
English: For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
Danish: Hvis du ønsker yderligere oplysninger om Levetiracetam Teva, skal du henvende dig til den lokale repræsentant for indehaveren af markedsføringstilladelsen:
English: Probenecid (500 mg four times daily), a renal tubular secretion blocking agent, has been shown to inhibit the renal clearance of the primary metabolite, but not of levetiracetam.
Danish: Det er påvist, at probenecid (500 mg fire gange daglig), en substans som blokerer den tubulære sekretion i nyrerne, hæmmer renal udskillelse af den primære metabolit men ikke af levetiracetam.
English: 20 film-coated tablets 30 film-coated tablets 50 film-coated tablets 50x1 film-coated tablet 60 film-coated tablets 100 film-coated tablets 120 film-coated tablets 200 film-coated tablets
Danish: 20 filmovertrukne tabletter 30 filmovertrukne tabletter 50 filmovertrukne tabletter 50 x 1 filmovertrukken tablet 60 filmovertrukne tabletter 100 filmovertrukne tabletter 120 filmovertrukne tabletter 200 filmovertrukne tabletter
English: What you need to know before you take Levetiracetam Teva Do not take Levetiracetam Teva
Danish: Det skal du vide, før du begynder at tage Levetiracetam Teva Tag ikke Levetiracetam Teva
English: Production of the primary metabolite, ucb L057, is not supported by liver cytochrome P450 isoforms.
Danish: Dannelse af den primære metabolit, ucb L057 er ikke afhængigt af CYP-isozymer.
English: You should continue Levetiracetam Teva treatment for as long as your doctor has told you.
Danish: Levetiracetam Teva så lang tid, som din læge har fortalt dig.
English: Furthermore, levetiracetam has been shown in in vitro studies to bind to a specific site in rodent brain tissue.
Danish: Endvidere blev det i in vitro-studier påvist, at levetiracetam bindes til et specifikt sted i hjernevæv hos gnavere.
English: This finding suggests that the interaction between levetiracetam and the synaptic vesicle protein 2A seems to contribute to the antiepileptic mechanism of action of the medicinal product.
Danish: Dette fund tyder på, at interaktionen mellem levetiracetam og det synaptiske vesikelprotein 2A bidrager til lægemidlets antiepileptiske virkningsmekanisme.
English: General dose: between 1,000 mg and 3,000 mg each day.
Danish: Den sædvanlige dosis er mellem 1.000 mg og 3.000 mg dagligt.
English: At 3600 mg/kg/day, in only one of the 2 EFD studies, there was a slight decrease in foetal weight associated with a marginal increase in skeletal variations/minor anomalies.
Danish: Kun i ét af de to embryo-føtale udviklingsstudier med 3.600 mg/kg/dag var der et lille fald i fostervægt forbundet med en marginal forøgelse af skeletale ændringer/mindre anomalier.
English: Each Levetiracetam Teva 250, 500, 750, 1,000 mg film-coated tablet contains 250, 500, 750, 1,000 mg levetiracetam.
Danish: En Levetiracetam Teva 250, 500, 750, 1.000 mg filmovertrukken tablet indeholder 250, 500, 750, 1.000 mg levetiracetam.
English: The daily dose must be individualised according to renal function.
Danish: Den daglige dosis skal juseres individuelt i forhold til nyrefunktion.
English: • as an add-on to other antiepileptic medicines to treat: ■ partial onset seizures with or without generalisation in adults, adolescents, children and infants from one month of age ■ myoclonic seizures (short, shock-like jerks of a muscle or group of muscles) in adults and adolescents from 12 years of age with juvenile myoclonic epilepsy ■ primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic generalised epilepsy (the type of epilepsy that is thought to have a genetic cause).
Danish: • som tillægsbehandling til andre antiepileptika til behandling af: - partielle anfald med eller uden generalisering hos voksne, unge, børn og spædbørn, der er over 1 måned gamle - myoklone anfald (korte, chok-lignende ryk i en muskel eller i en gruppe af muskler) hos voksne og unge over 12 år med juvenil myoklon epilepsi - primært generaliserede tonisk-kloniske anfald (større anfald inklusiv bevidstløshed) hos voksne og unge over 12 år med idiopatisk generaliseret epilepsi (den type epilepsi, som menes at være genetisk forårsaget)
English: • flu-like symptoms and a rash on the face followed by an extended rash with a high temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes (Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS])
Danish: • influenzalignende symptomer og udslæt i ansigtet, som efterfølges af udbredt udslæt med feber, forhøjede leverenzymniveauer i blodprøver og et forhøjet antal af en bestemt type hvide blodlegemer (eosinofili) og forstørrede lymfekirtler (lægemiddelreaktion med eosinofili og systemiske reaktioner [DRESS])
English: Levetiracetam Teva contains Sodium
Danish: Levetiracetam Teva indeholder natrium
English: • skin rash, which may form blisters and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) (erythema multiforme), a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (StevensJohnson syndrome), and a more severe form causing skin peeling in more than 30 % of the body surface (toxic epidermal necrolysis).
Danish: • hududslæt, der kan danne blærer, og som ligner små skydeskiver (mørk plet i midten omgivet af et blegere område, med en mørk ring om kanten) (erythema multiforme), et udbredt udslæt med blærer og skællende hud, især omkring munden, næsen, øjnene og kønsdelene (Stevens-Johnson syndrom), og en mere alvorlig form, der medfører afskalning af huden på mere end 30 % af kroppens overflade (toksisk epidermal nekrolyse);
English: In adults, levetiracetam efficacy has been demonstrated in 3 double-blind, placebo-controlled studies at 1000 mg, 2000 mg, or 3000 mg/day, given in 2 divided doses, with a treatment duration of up to 18 weeks.
Danish: Virkningen af levetiracetam hos voksne er blevet demonstreret i 3 dobbeltblinde placebokontrollerede studier med hhv. 1.000 mg, 2.000 mg eller 3.000 mg/dag, fordelt på to doser, med en behandlingsvarighed på op til 18 uger.
English: Contents of the pack and other information What Levetiracetam Teva contains
Danish: Pakningsstørrelser og yderligere oplysninger Levetiracetam Teva indeholder
English: Levetiracetam Teva is indicated as adjunctive therapy
Danish: Levetiracetam Teva er indiceret til tillægsbehandling
English: Levetiracetam and related analogs show a rank order of affinity for binding to the synaptic vesicle protein 2A which correlates with the potency of their anti-seizure protection in the mouse audiogenic model of epilepsy.
Danish: Levetiracetam og beslægtede analoger udviser en rangordnet affinitet for binding til det synaptiske vesikelprotein 2A, som i den audiogene epilepsi-model på mus er korreleret til antikonvulsiv potens.
English: The NOAEL was < 200 mg/kg/day for the dams and 200 mg/kg/day for the foetuses (equal to the MRHD on a mg/m2 basis).
Danish: NOAEL var < 200 mg/kg/dag for hunnerne og 200 mg/kg/dag for fostrene (svarende til MRHD på basis af mg/m2).
English: Bone marrow suppression was identified in some of the cases of pancytopenia.
Danish: Der har været rapporteret om knoglemarvssuppression i nogle af tilfældende med pancytopeni.
English: In this study, levetiracetam dose was 3000 mg/day for adults and adolescents or 60 mg/kg/day for children, given in 2 divided doses.
Danish: I dette forsøg var dosis af levetiracetam 3.000 mg/dag for voksne og unge og 60 mg/kg/dag for børn, fordelt på 2 doser.
English: In human hepatocytes in culture, levetiracetam had little or no effect on CYP1A2, SULT1E1 or UGT1A1.
Danish: Levetiracetam havde lille eller ingen virkning på CYP1A2, SULT1E1 eller UGT1A 1 i kulturer af humane hepatocytter.
English: After an acute overdose, the stomach may be emptied by gastric lavage or by induction of emesis.
Danish: Efter en akut overdosis bør ventriklen tømmes ved hjælp af ventrikelskylning og induktion af opkastning.
English: Levetiracetam efficacy was established in a 24-week double-blind, placebo-controlled study which included adults, adolescents and a limited number of children suffering from idiopathic generalized epilepsy with primary generalized tonic-clonic (PGTC) seizures in different syndromes (juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, or epilepsy with Grand Mal seizures on awakening).
Danish: Virkningen af levetiracetam blev påvist i et 24 ugers dobbeltblindt placebokontrolleret studie, som omfattede voksne og unge samt et begrænset antal børn med idiopatisk generaliseret epilepsi med primært generaliserede tonisk-kloniske anfald (PGTC) i forskellige syndromer (juvenil myoklon epilepsi, juvenil absence epilepsi, børne absence epilepsi eller epilepsi med Grand Mal anfald ved opvågning).
English: • Levetiracetam Teva is not indicated in children and adolescents below 16 years on its own (monotherapy).
Danish: • Levetiracetam Teva, som eneste lægemiddel (monoterapi), er ikke indiceret til børn og unge under 16 år.
English: A peri- and post-natal development study was performed in rats with levetiracetam doses of 70, 350 and 1800 mg/kg/day.
Danish: Der blev udført et peri- og postnatalt udviklingsstudier med levetiracetam-doser på 70, 350 og 1.800 mg/kg/dag i rotter.
English: Creatinine clearance (ml/min/1.73 m2)
Danish: Kreatininclearance (ml/min/1,73 m2)
English: For children 6 years and above, an oral solution should be used for doses under 250 mg, for doses not multiple of 250 mg when dosing recommendation is not achievable by taking multiple tablets and for patients unable to swallow tablets.
Danish: For børn, der er 6 år og ældre, bør en oral opløsning anvendes ved doser under 250 mg, for doser, som ikke er delelig med 250 mg, når anbefalet dosis ikke kan opnås ved at tage flere tabletter og til patienter, som ikke er i stand til at synke tabletter.
English: In addition, the available dose strengths of the tablets are not appropriate for initial treatment in children weighing less than 25 kg, for patients unable to swallow tablets or for the administration of doses below 250 mg.
Danish: Derudover er de tilgængelige tabletstyrker ikke egnede til initialbehandling af børn, der vejer under 25 kg, til patienter, der ikke er i stand til at synke tabletter eller til administration af doser under 250 mg. I ovenstående tilfælde bør en oral opløsning anvendes.
English: • Dose in adults and adolescents (12 to 17 years) weighing 50 kg or more:
Danish: • Dosis til voksne og unge (12 til 17 år), som vejer 50 kg eller mere:
English: - The active substance is levetiracetam.
Danish: • Aktivt stof: levetiracetam.
English: Completed suicide, personality disorder, thinking abnormal, delirium
Danish: Selvmord , personlighedsfo rstyrrelse, abnorm tankegang, delirium
English: Pack sizes of 20, 30, 50, 60, 100, 120 and 200 film-coated tablets and 50 x 1 film-coated tablets in PVC/PVdC - aluminium perforated unit dose blisters.
Danish: Pakningsstørrelser med 20, 30, 50, 60, 100, 120 og 200 filmovertrukne tabletter og 50 x 1 filmovertrukken tablet i pvc/PVdC-aluminium perforeret enkeltdosisblister.
English: Other medicines and Levetiracetam Teva
Danish: Brug af anden medicin sammen med Levetiracetam Teva
English: Levetiracetam Teva 750 mg contains Sunset Yellow
Danish: Levetiracetam Teva 750 mg indeholder sunset yellow
English: Efficacy of levetiracetam as monotherapy was established in a double-blind, parallel group, non-inferiority comparison to carbamazepine controlled release (CR) in 576 patients 16 years of age or older with newly or recently diagnosed epilepsy.
Danish: Virkningen af levetiracetam som monoterapi behandling blev påvist i et dobbeltblindt, ækvivalensstudie med parallelle grupper med carbamazepin depottabletter (CR) hos 576 patienter over 16 år med ny eller nyligt diagnosticeret epilepsi.
English: If you stop taking Levetiracetam Teva
Danish: Hvis du holder op med at tage Levetiracetam Teva
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu
Danish: Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu og på Lægemiddelstyrelsens hjemmeside http://www.laegemiddelstyrelsen.dk.
English: The possible side effects of an overdose of Levetiracetam Teva are sleepiness, agitation, aggression, decrease of alertness, inhibition of breathing and coma.
Danish: Bivirkningerne af en overdosis af Levetiracetam Teva er søvnighed, uro, aggressiv adfærd, nedsat årvågenhed, vejrtrækningsbesvær og koma.
English: Very common: may affect more than 1 in 10 people
Danish: Meget almindelig: kan forekomme hos flere end 1 ud af 10 patienter
English: Suicide attempt, suicidal ideation, psychotic disorder, abnormal behaviour, hallucination, anger, confusional state , panic attack, affect lability/mood swings, agitation
Danish: Selvmordsforsøg, selvmordstanker, psykose, unormal adfærd, hallucinationer, vrede, konfusion, panikanfald, affektlabilitet/humør svingninger, agitation
English: Levetiracetam Teva 750 mg contains the colouring agent sunset yellow (E110) that may cause allergic reactions.
Danish: Levetiracetam Teva 750 mg indeholder farvestoffet sunset yellow (E110), der kan medføre allergiske reaktioner.
English: Levetiracetam Teva are available in pack sizes of 20, 30, 50, 60, 100, 120 and 200 film-coated tablets and 50 x 1 film-coated tablets in PVC/PVdC - aluminium perforated unit dose blisters.
Danish: Levetiracetam Teva fås i pakningsstørrelser med 20, 30, 50, 60, 100, 120 og 200 filmovertrukne tabletter og 50 x 1 filmovertrukken tablet i pvc/PVdC-aluminium perforeret enkeltdosisblister.
English: Levetiracetam Teva 500 mg contains the colouring agent tartrazine (E102) that may cause allergic reactions.
Danish: Levetiracetam Teva 500 mg indeholder farvestoffet tartrazin (E102), der kan medføre allergiske reaktioner.
English: Do not throw away any medicines via wastewater or household waste.
Danish: Af hensyn til miljøet må du ikke smide medicnrester i afløbet, toilettet eller skraldespanden.
English: The maximum dose is 1500 mg twice daily.
Danish: Den maksimale dosis er 1.500 mg to gange daglig.
English: If you forget to take Levetiracetam Teva
Danish: Hvis du har glemt at tage Levetiracetam Teva
English: 10 to 20 mg/kg once daily (3) (5)
Danish: 10 til 20 mg/kg en gang daglig(3) (5)
English: Levetiracetam has been given to you by your doctor to reduce the number of fits.
Danish: Du har fået levetiracetam af din læge for at nedbringe antallet af anfald
English: Four embryo-foetal development studies were performed in rabbits covering doses of 200, 600, 800, 1200 and 1800 mg/kg/day.
Danish: Der blev udført fire embryo-føtale udviklingsstudier med doser på 200, 600, 800, 1.200 og 1.800 mg/kg/dag i kaniner.
English: The NOAEL was ≥ 1800 mg/kg/day for the F0 females, and for the survival, growth and development of the F1 offspring up to weaning (x 6 the MRHD on a mg/m2 basis).
Danish: NOAEL var ≥ 1.800 mg/kg/dag for F0-hunnerne samt for overlevelse, vækst og udvikling af F1-afkom indtil ophør af diegivning (6 x MRHD på basis af mg/m2).
English: In this study, levetiracetam, dose was 3000 mg/day given in 2 divided doses.
Danish: I dette studie var dosis af levetiracetam 3.000 mg/dag fordelt på 2 doser.
English: Two embryo-foetal development (EFD) studies were performed in rats at 400, 1200 and 3600 mg/kg/day.
Danish: Der blev udført to embryo-føtale udviklingsstudier med 400, 1.200 og 3.600 mg/kg/dag i rotter.
English: (1)An oral solution should be used for doses under 250 mg, for doses not multiple of 250 mg when dosing recommendation is not achievable by taking multiple tablets and for patients unable to swallow tablets.
Danish: dialyse (1)En oral opløsning bør anvendes ved doser under 250 mg, for doser, som ikke er delelig med 250 mg, når anbefalet dosis ikke kan opnås ved at tage flere tabletter og til patienter, der ikke er i stand til at synke tabletter.