FrancophonIA/ELRC3.0 huggingface dataset:
English: ** The incidence rates of myocardial infarction and other ischaemic heart disease events (0.43% and 1.54%, respectively) are derived from an analysis of 13 double-blind studies involving 2,082 patients with end-of-dose motor fluctuations receiving entacapone.
Croatian: ** Stope incidencije infarkta miokarda i drugih događaja vezanih uz ishemijsku srčanu bolest (0,43%, odnosno, 1,54%) su izvedene iz analize 13 dvostruko slijepih ispitivanja u koja su bila uključena 2082 bolesnika s motoričkim fluktuacijama pri kraju doze, a koji su primali entakapon.
English: - The film-coating contains partly hydrolysed polyvinyl alcohol, talc, macrogol, soya lecithin,
Croatian: - Ovojnica tablete sadrži polivinilni alkohol, djelomično hidroliziran, talk, makrogol, sojin lecitin,
English: Some of the adverse reactions, such as dyskinesia, nausea, and abdominal pain, may be more common with the higher doses (1,400 to 2,000 mg per day) than with the lower doses of entacapone.
Croatian: Neke od nuspojava, kao diskinezija, mučnina i bol u abdomenu, mogu biti češće s višim dozama (1400 do 2000 mg na dan) nego s nižim dozama entakapona.
English: • binge eating (eating large amounts of food in a short time period) or compulsive eating
Croatian: • nekontrolirano prejedanje (jedenje velikih količina hrane u kratkom razdoblju) ili kompulzivno jedenje (jedenje više hrane nego što je normalno i potrebno za utaživanje gladi).
English: Clinical interaction studies with diazepam and nonsteroidal anti-inflammatory medicinal products have not been carried out.
Croatian: Klinička ispitivanja interakcija s diazepamom i nesteroidnim protuupalnim lijekovima nisu provedena.
English: Entacapone is indicated as an adjunct to standard preparations of levodopa/benserazide or levodopa/carbidopa for use in adult patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.
Croatian: Entakapon je indiciran kao dodatak standardnim preparatima levodope/benzerazida ili levodope/karbidope, za primjenu u odraslih bolesnika s Parkinsonovom bolešću i motoričkim fluktuacijama pri kraju doze, koji se ne mogu stabilizirati tim kombinacijama.
English: COMT inhibition in red blood cells closely follows the plasma concentrations of entacapone, thus clearly indicating the reversible nature of COMT inhibition.
Croatian: Inhibicija COMT u eritrocitima vjerno prati koncentracije entakapona u plazmi, što jasno ukazuje na reverzibilnu prirodu inhibicije COMT.
English: • a rare severe muscle disorder (rhabdomyolysis) which causes pain, tenderness and weakness of the muscles and may lead to kidney problems.
Croatian: • rijedak, teški mišićni poremećaj (rabdomioliza) koji uzrokuje bol, osjetljivost i slabost mišića i može dovesti do problema s bubrezima.
English: Baseline Week 8-24 10.7±2.2
Croatian: Tjedan 8-24 10,7±2,2
English: • discolouration of skin, hair, beard and nails.
Croatian: • promjena boje kože, kose, brade i noktiju.
English: Entacapone should be given cautiously to patients who are taking other medicinal products which may cause orthostatic hypotension.
Croatian: Entakapon treba davati s oprezom bolesnicima koji uzimaju druge lijekove, a koji mogu izazvati ortostatsku hipotenziju.
English: In two phase III double-blind studies in a total of 376 patients with Parkinson's disease and end-ofdose motor fluctuations, entacapone or placebo was given with each levodopa/dopa decarboxylase inhibitor dose.
Croatian: U dva dvostruko slijepa ispitivanja faze III s ukupno 376 bolesnika s Parkinsonovom bolešću i motoričkim fluktuacijama pri kraju doze davani su entakapon ili placebo sa svakom dozom inhibitora levodope/dopa dekarboksilaze.
English: • if you experience diarrhoea, monitoring of your weight is recommended in order to avoid potentially excessive weight loss;
Croatian: • ako imate proljev, preporučuje se praćenje Vaše tjelesne težine kako bi se izbjegao moguć prekomjerni gubitak tjelesne težine;
English: • harmless reddish-brown discolouration of urine.
Croatian: • bezopasno crvenkasto-smeđe obojenje mokraće.
English: Uncommon (may affect up to 1 in 100 people): • Heart attack.
Croatian: Manje često (mogu se javiti u manje od 1 na 100 osoba): • srčani udar.
English: - Hypersensitivity to the active substance or to peanut or soya or to any of the excipients listed in section 6.1.
Croatian: - Preosjetljivost na djelatnu tvar ili kikiriki ili soju ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: When considered necessary, withdrawal of entacapone and other dopaminergic treatment should proceed slowly, and if signs and/or symptoms occur despite a slow withdrawal of entacapone, an increase in levodopa dosage may be necessary.
Croatian: Kad se pokaže potrebnim, liječenje entakaponom i drugim dopaminergičkim lijekovima treba ukidati polako, a ako se usprkos polaganog ukidanja entakapona pojave znakovi i/ili simptomi, može biti potrebno povećanje doziranja levodope.
English: It is characterised by stiffness, muscle twitching, shaking, agitation and confusion, coma, high body temperature, increased heart rate, and unstable blood pressure;
Croatian: Karakteriziran je ukočenošću, trzanjem mišića, drhtavicom, uznemirenošću, smetenošću, komom, visokom tjelesnom temperaturom, povećanom brzinom otkucaja srca i nestabilnim krvnim tlakom;
English: Talk to your doctor or pharmacist before taking Entacapone Orion:
Croatian: Obratite se svom liječniku ili ljekarniku prije nego uzmete Entacapone
English: If entacapone treatment is discontinued, it is necessary to adjust the dosing of other antiparkinsonian treatments, especially levodopa, to achieve a sufficient level of control of the parkinsonian symptoms.
Croatian: Ako se liječenje entakaponom prekine, nužno je prilagoditi doziranje ostalih lijekova za Parkinsonovu bolest, posebno levodope, kako bi se postigao zadovoljavajući nadzor nad simptomima Parkinsonove bolesti.
English: Entacapone Orion in association with levodopa may have a major influence on the ability to drive and use machines.
Croatian: Orion udružen s levodopom može imati velik utjecaj na sposobnost upravljanja vozilima i strojevima.
English: Excipient with known effect Each film-coated tablet contains 0.53 mg soya lecithin.
Croatian: Pomoćna tvar s poznatim učinkom Jedna filmom obložena tableta sadržava 0,53 mg sojina lecitina.
English: Entacapone therapy should be administered cautiously to patients with ischaemic heart disease.
Croatian: Terapiju entakaponom treba provoditi uz oprez u bolesnika s ishemijskom bolešću srca.
English: At therapeutic concentrations, entacapone does not displace other extensively bound substances (e.g. warfarin, salicylic acid, phenylbutazone, or diazepam), nor is it displaced to any significant extent by any of these substances at therapeutic or higher concentrations.
Croatian: U terapijskim koncentracijama, entakapon ne istiskuje druge, snažno vezane lijekove (npr. varfarin, salicilnu kiselinu, fenilbutazon ili diazepam), niti ga bilo koji od ovih lijekova može značajnije istisnuti u terapijskim ili višim koncentracijama.
English: Entacapone Orion may make it harder for you to digest iron.
Croatian: Entacapone Orion može otežati probavu željeza.
English: Entacapone decreases the metabolic loss of levodopa to 3-O-methyldopa (3-OMD) by inhibiting the COMT enzyme.
Croatian: Entakapon smanjuje metaboličku pretvorbu levodope u 3-Ometildopu (3-OMD) inhibirajući enzim COMT.
English: Do not use Entacapone Orion during pregnancy or if you are breast-feeding.
Croatian: Orion nemojte koristiti tijekom trudnoće i dojenja.
English: What Entacapone Orion is and what it is used for
Croatian: Orion i za što se koristi
English: The bioavailability of entacapone is about 35% after an oral dose.
Croatian: Bioraspoloživost entakapona nakon oralne doze iznosi oko 35%.
English: In study I, daily ON time (hours) was measured from home diaries and in study II, the proportion of daily ON time.
Croatian: U ispitivanju I, dnevno trajanje „ON“ faze (sati) mjereno je na temelju dnevnika vođenih kod kuće, dok je u ispitivanju II mjeren udio dnevnog trajanja „ON“ faze.
English: • antidepressants including desipramine, maprotiline, venlafaxine, paroxetine;
Croatian: • antidepresivi uključujući: desipramin, maprotilin, venlafaksin, paroksetin;
English: In clinical studies, undesirable dopaminergic effects, e.g. dyskinesia, were more common in patients who received entacapone and dopamine agonists (such as bromocriptine), selegiline or amantadine compared to those who received placebo with this combination.
Croatian: U kliničkim ispitivanjima, neželjeni dopaminergički učinci, npr. diskinezija, bili su češći u bolesnika koji su primali entakapon i agoniste dopamina (kao bromokriptin), selegilin ili amantadin u usporedbi s onima koji su primali placebo s tom kombinacijom.
English: Since the introduction into the market, isolated cases of NMS have been reported, especially following abrupt reduction or discontinuation of entacapone and other concomitant dopaminergic medicinal products.
Croatian: Otkada se nalazi na tržištu, zabilježeni su izolirani slučajevi NMS-a, posebno nakon naglog smanjenja doze ili prekida primjene entakapona i ostalih istovremeno primijenjenih dopaminergičkih lijekova.
English: Patients being treated with entacapone in association with levodopa and presenting with somnolence and/or sudden sleep onset episodes must be instructed to refrain from driving or engaging in activities where impaired alertness may put themselves or others at risk of serious injury or death (e.g. operating machines) until such recurrent episodes have resolved (see also section 4.4).
Croatian: Bolesnike koji se liječe entakaponom u kombinaciji s levodopom te osjećaju pospanost i/ili imaju epizode iznenadnog nastupa sna, treba uputiti da se suzdržavaju od upravljanja vozilima ili od aktivnosti u kojima bi poremećena budnost mogla biti opasna za njih ili druge osobe zbog rizika od teške ozljede ili smrti (npr. rad sa strojevima), sve dok ponavljanje takvih epizoda ne prestane (vidjeti također dio 4.4).
English: NMS, including rhabdomyolysis and hyperthermia, is characterised by motor symptoms (rigidity, myoclonus, tremor), mental status changes (e.g. agitation, confusion, coma), hyperthermia, autonomic dysfunction (tachycardia, labile blood pressure) and elevated serum creatine phosphokinase.
Croatian: Za NMS, uključujući rabdomiolizu i hipertermiju, karakteristični su motorički simptomi (rigidnost, mioklonus, tremor), promjene mentalnog stanja (npr. agitacija, konfuzija, koma), hipertermija, autonomna disfunkcija (tahikardija, varijabilni krvni tlak) i povišena kreatin fosfokinaza u serumu.
English: • if you experience prolonged diarrhoea consult your doctor as it may be a sign of inflammation of the colon;
Croatian: • ako dobijete dugotrajni proljev, savjetujte se sa svojim liječnikom jer to može biti znak upale debelog crijeva;
English: In clinical studies the most common adverse reactions leading to discontinuation of entacapone treatment have been gastrointestinal symptoms (e.g. diarrhoea, 2.5%) and increased dopaminergic adverse reactions of levodopa (e.g. dyskinesias, 1.7%).
Croatian: Najčešće nuspojave u kliničkim ispitivanjima, koje su zahtijevale prekid liječenja entakaponom, bile su probavni simptomi (npr. proljev, 2,5%) i povećane dopaminergičke nuspojave levodope (npr. diskinezije, 1,7%).
English: Entacapone in association with levodopa has been associated with somnolence and episodes of sudden sleep onset in patients with Parkinson's disease and caution should therefore be exercised when driving or operating machines (see also section 4.7).
Croatian: Entakapon udružen s levodopom je povezan sa somnolencijom i epizodama iznenadnog nastupa sna u bolesnika s Parkinsonovom bolešću, pa se preporučuje oprez prilikom upravljanja vozilima i rukovanja strojevima (vidjeti također dio 4.7).
English: Renal insufficiency does not affect the pharmacokinetics of entacapone and there is no need for dose adjustment.
Croatian: Bubrežna insuficijencija ne utječe na farmakokinetiku entakapona, pa nije potrebno posebno prilagođavanje doze.
English: What Entacapone Orion is and what it is used for What you need to know before you take Entacapone Orion How to take Entacapone Orion Possible side effects
Croatian: Orion i za što se koristi Što morate znati prije nego počnete uzimati Entacapone Orion Kako uzimati Entacapone Orion Moguće nuspojave
English: • Inflammation of the colon (colitis), inflammation of the liver (hepatitis) with yellowing of the skin and whites of the eyes;
Croatian: • upala debelog crijeva (kolitis), upala jetre (hepatitis) s požutjelom kožom i bjeloočnicama;
English: Entacapone Orion taken together with levodopa may lower your blood pressure, which may make you feel light-headed or dizzy.
Croatian: Orion uzet zajedno s levodopom može sniziti Vaš krvni tlak, zbog čega možete osjetiti laganu ošamućenost ili omaglicu.
English: For patients who experience progressive anorexia, asthenia and weight decrease within a relatively short period of time, a general medical evaluation including liver function should be considered.
Croatian: U bolesnika s progresivnom anoreksijom, astenijom i smanjenjem tjelesne težine unutar relativno kratkog vremenskog perioda, potrebno je razmisliti o općem liječničkom pregledu, uključujući pretragu jetrene funkcije.
English: • rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa,
Croatian: • rimiterol, izoprenalin, adrenalin, noradrenalin, dopamin, dobutamin, alfa-metildopa apomorfin;
English: • dizziness, tiredness, increased sweating, fall;
Croatian: • omaglica, umor, pojačano znojenje, pad;
English: The metabolism of the medicinal product is slowed in patients with mild to moderate liver insufficiency (Child-Pugh Class A and B), which leads to an increased plasma concentration of entacapone in both the absorption and elimination phases (see section 4.3).
Croatian: U osoba s blagom do umjerenom insuficijencijom jetre (Child-Pugh stadij A i B) usporen je metabolizam lijeka, što dovodi do povišene koncentracije entakapona u plazmi i u fazi apsorpcije kao i u fazi eliminacije (vidjeti dio 4.3).
English: Ischaemic heart disease events other than myocardial infarction (e.g. angina pectoris)
Croatian: Događaji vezani uz ishemijsku srčanu bolest koji ne uključuju infarkt miokarda (npr. angina pektoris)
English: Reduction of levodopa dosage decreases the severity and frequency of these reactions.
Croatian: Sniženje doziranja levodope smanjuje težinu i učestalost tih nuspojava.
English: The most frequent adverse reactions caused by entacapone relate to the increased dopaminergic activity and occur most commonly at the beginning of treatment.
Croatian: Najčešće nuspojave izazvane entakaponom odnose se na povišenu dopaminergičku aktivnost, a najčešće se javljaju na početku liječenja.
English: Your doctor may advise you to slowly discontinue the treatment with Entacapone Orion and other medicines to treat Parkinson's disease.
Croatian: Liječnik Vam može savjetovati polagano prekidanje liječenja Entacapone Orionom i drugim lijekovima za terapiju Parkinsonove bolesti.
English: Entacapone enhances the effects of levodopa.
Croatian: Entakapon pojačava učinak levodope.
English: Therefore, do not take Entacapone Orion and iron supplements at the same time.
Croatian: Orion i preparate željeza u isto vrijeme.
English: Brownish-orange, oval, biconvex film-coated tablet with "COMT" engraved on one side.
Croatian: Smećkasto-narančasta, ovalna, bikonveksna filmom obložena tableta, s utisnutim „COMT“ na jednoj strani.
English: Entacapone Orion has no effect on relieving the symptoms of Parkinson's disease unless taken with levodopa.
Croatian: Orion nema učinak ublažavanja simptoma Parkinsonove bolesti ako nije uzet s levodopom.
English: Bottle label
Croatian: Naljepnica za bočicu
English: A small amount of entacapone, the (E)-isomer, is converted to its (Z)-isomer.
Croatian: Mala količina entakapona, (E)-izomer, pretvara se u njegov (Z)-izomer. (E)-izomer čini 95% AUC vrijednosti entakapona.
English: However, the experience of the clinical use of entacapone with several medicinal products, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine, and medicinal products that are metabolised by COMT (e.g. catechol structured compounds: rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine,alpha-methyldopa, apomorphine, and paroxetine) is still limited.
Croatian: Međutim, još uvijek je ograničeno iskustvo kliničke primjene entakapona s nekoliko lijekova, uključujući MAO-A inhibitore, tricikličke antidepresive, inhibitore ponovne pohrane noradrenalina kao što su dezipramin, maprotilin i venlafaksin te lijekove koji se metaboliziraju putem COMT-a (npr. spojevi s kateholskom strukturom: rimiterol, izoprenalin, adrenalin, noradrenalin, dopamin, dobutamin, alfa-metildopa, apomorfin i paroksetin).
English: One 200 mg tablet is taken with each levodopa/dopa decarboxylase inhibitor dose.
Croatian: Jedna tableta od 200 mg uzima se sa svakom dozom inhibitora levodope/dopa dekarboksilaze.
English: The maximum recommended dose is 10 tablets per day, i.e. 2,000 mg of Entacapone Orion.
Croatian: Najveća preporučena doza je 10 tableta na dan, odnosno 2000 mg Entacapone
English: • heart or artery disease events (e.g. chest pain).
Croatian: • simptomi srčane ili arterijske bolesti (npr. bol u prsištu).
English: In doses of 1,400 to 2,000 mg per day, the following side effects are more common:
Croatian: Orion primijenjen u visokim dozama: U dozama od 1400 do 2000 mg po danu, slijedeće nuspojave su češće:
English: For patients experiencing diarrhoea, a follow-up of weight is recommended in order to avoid potential excessive weight decrease.
Croatian: U bolesnika s proljevom preporučuje se praćenje tjelesne težine, kako bi se izbjegla mogućnost prekomjernog gubitka tjelesne težine.
English: What you need to know before you take Entacapone Orion
Croatian: Što morate znati prije nego počnete uzimati Entacapone Orion
English: As Entacapone Orion tablets will be taken together with other levodopa medicines, please also read the package leaflets of these medicines carefully.
Croatian: Orion tablete uzimaju zajedno s lijekovima na bazi levodope, molimo da pažljivo pročitate upute o lijeku i tih drugih lijekova.
English: Study I: Daily On time (h) Entacapone (n=85) Placebo (n=86)
Croatian: Ispitivanje I: dnevno trajanje „ON“ faze (sati) Entakapon (n=85)
English: • Neuroleptic Malignant Syndrome (NMS) is a rare severe reaction to medicines used to treat disorders of the nervous system.
Croatian: • NMS je rijetka teška reakcija na lijekove koji se koriste za liječenje poremećaja središnjeg živčanog sustava.
English: Other medicines and Entacapone Orion
Croatian: Drugi lijekovi i Entacapone
English: Neuroleptic Malignant Syndrome (NMS) is a serious but rare reaction to certain medicines, and may occur especially when Entacapone Orion and other medicines to treat Parkinson's disease are suddenly stopped or the dose is suddenly reduced.
Croatian: Neuroleptički maligni sindrom (NMS) je ozbiljna ali rijetka reakcija na neke lijekove, i može se javiti naročito kada se naglo prekine uzimanje Entacapone
English: Entacapone Orion tablets contain entacapone and are used together with levodopa to treat Parkinson's disease.
Croatian: Orion tablete sadrže entakapon i primjenjuju se zajedno s levodopom za liječenje Parkinsonove bolesti.
English: The other major class of adverse reactions are gastrointestinal symptoms, including nausea, vomiting, abdominal pain, constipation and diarrhoea.
Croatian: Drugu veću skupinu nuspojava čine probavni simptomi, uključujući mučninu, povraćanje, bol u abdomenu, konstipaciju i proljev.
English: Diarrhoea, abdominal pain, dry mouth, constipation, vomiting
Croatian: Proljev, bol u abdomenu, suha usta, konstipacija, povraćanje
English: What Entacapone Orion looks like and contents of the pack Entacapone Orion 200 mg film-coated tablets are brownish-orange, oval tablets with "COMT" engraved on one side.
Croatian: Orion izgleda i sadržaj pakiranja Entacapone Orion 200 mg filmom obložene tablete su smećkasto-narančaste, ovalne tablete s utisnutim „COMT“ na jednoj strani.
English: Entacapone Orion aids levodopa in relieving the symptoms of Parkinson's disease.
Croatian: Entacapone Orion pomaže levodopi u ublažavanju simptoma Parkinsonove bolesti.
English: • Excessive movements (hyperkinesias), worsening of symptoms of Parkinson´s disease,
Croatian: • pretjerani pokreti (hiperkinezije), pogoršanje simptoma Parkinsonove bolesti, produženo trajanje grčeva mišića (distonija);
English: Patients and carers should be made aware that behavioural symptoms of impulse control disorders including pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists and/or other dopaminergic treatments such as Entacapone Orion in association with levodopa.
Croatian: Bolesnici i osobe koje se brinu o njima trebaju biti svjesni da se simptomi poremećaja ponašanja kontrole impulsa kao što su patološko kockanje, pojačan libido, hiperseksualnost, kompulzivno trošenje ili kupovanje, nekontrolirano prejedanje i kompulzivno jedenje mogu javiti u bolesnika liječenih agonistima dopamina i/ili drugim dopaminergicima poput Entacapone Oriona u kombinaciji s levodopom.
English: [carton only]:
Croatian: [samo na kutiji]
English: entacapone orion 200 mg [carton only]
Croatian: entacapone orion 200 mg [samo na kutiji]
English: • Rashes;
Croatian: • osipi;
English: If you stop taking Entacapone Orion Do not stop taking Entacapone Orion unless your doctor tells you to.
Croatian: Orion nemojte prestati uzimati, osim ako Vam to ne kaže liječnik.
English: Entacapone Orion taken with levodopa may cause drowsiness and may cause you to sometimes suddenly fall asleep.
Croatian: Orion uzet s levodopom može izazvati pospanost i može dovesti do toga da ponekad iznenada utonete u san.
English: • if you are taking a medicine which may cause dizziness or light-headedness (low blood pressure) when rising from a chair or bed;
Croatian: • ako uzimate lijekove koji mogu uzrokovati omaglicu ili laganu ošamućenost (sniženi krvni tlak)
English: When stopping your doctor may need to re-adjust the dosage of your other medicines to treat Parkinson´s disease.
Croatian: Kad prekinete uzimanje, liječnik će možda morati prilagoditi dozu ostalih lijekova za terapiju Parkinsonove bolesti.
English: Cardiac disorders** Common:
Croatian: Srčani poremećaji ** Često:
English: Suddenly stopping Entacapone Orion and other medicines to treat Parkinson´s disease may result in unwanted side effects.
Croatian: Nagli prekid primjene Entacapone Oriona, i drugih lijekova za terapiju Parkinsonove bolesti, može dovesti do nuspojava.
English: See section 4 Possible side effects for the characteristics of NMS;
Croatian: Za karakteristike NMS-a vidjeti dio 4 Moguće nuspojave;
English: Adverse drug reactions*
Croatian: Nuspojave na lijek*
English: Entacapone Orion contains soya lecithin.
Croatian: Orion sadrži sojin lecitin.
English: If you take more Entacapone Orion than you should In the event of an overdose, consult your doctor, pharmacist or the nearest hospital immediately.
Croatian: U slučaju predoziranja, odmah se obratite svom liječniku, ljekarniku ili najbližoj bolnici.
English: The substance is subject to extensive first-pass metabolism.
Croatian: Pri prvom prolasku kroz jetru lijek se snažno metabolizira.
English: What Entacapone Orion contains - The active substance is entacapone.
Croatian: Orion sadrži - Djelatna tvar je entakapon.
English: Impulse control disorders: Pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists and/or other dopaminergic treatments such as Entacapone Orion in association with levodopa (see section 4.4).
Croatian: Poremećaji kontrole impulsa: Patološko kockanje, pojačan libido, hiperseksualnost, kompulzivno trošenje ili kupovanje, nekontrolirano prejedanje i kompulzivno jedenje mogu se javiti u bolesnika liječenih agonistima dopamina i/ili drugim dopaminergicima poput Entacapone