FrancophonIA/ELRC3.0 huggingface dataset:
English: Lomitapide was not mutagenic or genotoxic in a battery of in vitro and in vivo studies.
Croatian: Lomitapid nije bio mutagen ili genotoksičan u bateriji ispitivanja in vitro i in vivo.
English: The European Medicines Agency will review any new information on this medicine every year and this leaflet will be updated as necessary.
Croatian: Europska agencija za lijekove će svake godine procjenjivati sve nove informacije o ovom lijeku te će se ova uputa ažurirati prema potrebi.
English: CARTON AND BOTTLE (5 mg, 10 mg, 20 mg, 30 mg, 40 mg and 60 mg)
Croatian: KUTIJA I BOČICA (5 mg, 10 mg, 20 mg, 30 mg, 40 mg i 60 mg)
English: • The need to avoid grapefruit juice;
Croatian: • Potreba izbjegavanja soka od grejpa.
English: • Compliance with the supplementation regimen should be verified at regular scheduled appointments and the importance emphasised.
Croatian: • Suradljivost sa režimom uzimanja dodataka prehrani treba provjeriti prilikom redovitih planiranih kontrola te naglasiti njihovu važnost.
English: Women who become pregnant should be counselled and referred to an expert in teratology;
Croatian: Ženama koje zatrudne potrebno je savjetovanje i treba ih uputiti liječniku specijaliziranom u teratologiji.
English: Adverse clinical consequences of these reductions were not observed with lomitapide treatment of up to 78 weeks.
Croatian: Štetne kliničke posljedice tih smanjenja nisu opažene uz terapiju lomitapidom do 78. tjedna.
English: Tell your doctor or pharmacist if you are taking any of the following medicines:
Croatian: Obavijestite liječnika ili ljekarnika ako uzimate neki od sljedećih lijekova:
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Lojuxta in one or more subsets of the paediatric population in HoFH (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove je odgodila obvezu podnošenja rezultata ispitivanja lijeka Lojuxta u jednoj ili više podskupina pedijatrijske populacije za indikaciju HoFH (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: In an open-label Phase 3 study, 18 of 23 patients with HoFH developed hepatic steatosis (hepatic fat >5.56%) as measured by nuclear magnetic resonance spectroscopy (MRS) (see section 5.1).
Croatian: U otvorenom ispitivanju faze 3, 18 od 23 bolesnika s HoFH-om razvilo je masnu jetru (mast u jetri > 5,56%) mjereno spektroskopskom metodom nuklearne magnetske rezonancije (MRS) (vidjeti dio 5.1).
English: Patients will be instructed to carry this card and show it to all doctors who treat them.
Croatian: Bolesnici će dobiti uputu da ovu karticu nose sa sobom i da je pokažu svim liječnicima koji ih liječe.
English: • The need to inform their doctor of all other medicines they are taking as special care should be taken if other medicines which can cause liver problems are taken at the same time;
Croatian: • Potreba da bolesnici obavijeste liječnike o svim drugim lijekovima koje uzimaju jer je potrebno posebno voditi računa o lijekovima koji mogu prouzročiti tegobe s jetrom ako se uzimaju istodobno.
English: This means that because of the rarity of this disease it has been impossible to get complete information on this medicine.
Croatian: To znači da zbog male učestalosti ove bolesti nije bilo moguće dobiti potpune informacije o ovom lijeku.
English: • weight loss
Croatian: • gubitak težine
English: Number of evaluable patients 22
Croatian: Broj bolesnika za procjenu 22
English: In a 1 year repeat-dose study in dogs there were no microscopic changes in the liver although serum AST was minimally increased in females.
Croatian: U 1-godišnjem ispitivanju ponovljenih doza u pasa nije bilo mikroskopskih promjena u jetri, iako su vrijednosti AST u serumu bile minimalno povišene u ženki.
English: Lomitapide is not expected to directly influence the efficacy of oestrogen based oral contraceptives; however diarrhoea and/or vomiting may reduce hormone absorption.
Croatian: Ne očekuje se da će lomitapid izravno utjecati na djelotvornost oralnih kontraceptiva na bazi estrogena; međutim, proljev i/ili povraćanje mogu smanjiti apsorpciju hormona.
English: • hair loss (alopecia)
Croatian: • gubitak kose (alopecija)
English: The recommended starting dose is a 5 mg capsule each day.
Croatian: Preporučena početna doza je jedna kapsula od 5 mg svakoga dana.
English: • aminoglutethimide - a medicine used to treat Cushing's syndrome
Croatian: • aminoglutetimid - lijek kojim se liječi Cushingov sindrom
English: • excessive sweating
Croatian: • prekomjerno znojenje
English: Appropriate patient selection
Croatian: Izbor odgovarajućih bolesnika
English: The absolute oral bioavailability of lomitapide is 7%.
Croatian: Apsolutna peroralna bioraspoloživost lomitapida iznosi 7%.
English: After 2 weeks the dose may be increased, based on acceptable safety and tolerability, to 10 mg and then, at a minimum of 4-week intervals, to 20 mg, 40 mg, and to the maximum recommended dose of 60 mg (see section 4.8).
Croatian: Nakon 2 tjedna dozu se može povećati na 10 mg, na temelju prihvatljive neškodljivosti i podnošljivosti, a zatim u intervalima od najmanje 4 tjedna povećati na 20 mg, 40 mg i na maksimalnu preporučljivu dozu od 60 mg (vidjeti dio 4.8).
English: If you take more Lojuxta than you should Contact your doctor or pharmacist immediately.
Croatian: Ako uzmete više lijeka Lojuxta nego što ste trebali Odmah se obratite svome liječniku ili ljekarniku.
English: • Information on the importance of following a low-fat diet (a diet supplying less than 20% of energy from fat);
Croatian: • Informacije o važnosti pridržavanja dijete s niskim udjelom masti (prehrana u kojoj se iz masti crpi manje od 20% energije).
English: Gastrointestinal (GI) effects
Croatian: Gastrointestinalni (GI) učinci
English: Baseline Week 26/LOCF (N=29)
Croatian: 26. tjedan/LOCF (N = 29)
English: The maximum dose administered to human subjects in clinical studies was 200 mg as a single dose; there were no adverse reactions.
Croatian: Maksimalna doza primijenjena u ljudi u kliničkim ispitivanjima bila je jednostruka doza od 200 mg; nije bilo nuspojava.
English: The purpose of the patient alert card is to inform health care professionals of potential drug-drug interactions before any additional medicinal product is prescribed.
Croatian: Svrha ove kartice s upozorenjima za bolesnika jest obavijestiti zdravstvene radnike o potencijalnim interakcijama lijekova prije nego što se bolesniku propiše bilo koji dodatni lijek.
English: • decrease in levels of potassium, carotene, vitamin E, vitamin K in your blood
Croatian: • smanjenje razina kalija, karotena, vitamina E, vitamina K u Vašoj krvi
English: Lojuxta with food, drink and alcohol
Croatian: Lojuxta s hranom, pićem i alkoholom
English: Effects of lomitapide on other medicinal products
Croatian: Učinci lomitapida na druge lijekove
English: • The need to inform their doctor if they have had any liver problems in the past;
Croatian: • Potreba da bolesnici obavijeste liječnike ako su u prošlosti imali tegobe s jetrom.
English: The risk of myopathy with simvastatin is dose related.
Croatian: Rizik od miopatije uz primjenu simvastatina povezan je s dozom.
English: If your tests show some liver problems, your doctor may decide to reduce your dose or stop the treatment.
Croatian: Ako nalazi Vaših pretraga pokažu da imate tegoba s jetrom, liječnik Vam može odlučiti smanjiti dozu ili obustaviti terapiju.
English: • Information about clinical findings (i.e., hepatic enzyme increases and steatosis) in subjects treated with Lojuxta during the developmental phase;
Croatian: • podaci iz kliničkih ispitivanja (tj. povećanje hepatičkih enzima i steatoze) u ispitanika liječenih Lojuxtom tijekom razvojne faze;
English: Inform your doctor of any change in the medicines you are taking.
Croatian: Obavijestite svog liječnika o svakoj promjeni vezanu uz lijekove koje uzimate.
English: In the Phase 3 study, 3 of 4 patients with ALT elevations >5x ULN reported alcohol consumption beyond the limits recommended in the protocol.
Croatian: U ispitivanju faze 3, u 3 od 4 bolesnika s povišenjem vrijednosti ALT > 5 x GGN zabilježena je konzumacija alkohola iznad ograničenja preporučenog protokolom.
English: Absorption is not limited by penetration of the active substance across the intestinal barrier but is predominantly influenced by an extensive first pass effect.
Croatian: Apsorpcija nije ograničena prolazom djelatne tvari kroz intestinalnu barijeru ali je u najvećem djelu pod utjecajem prvog prolaska kroz jetru.
English: In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required.
Croatian: U slučaju predoziranja, bolesnika treba liječiti simptomatski i uvesti potporne mjere po potrebi.
English: What Lojuxta looks like and contents of the pack
Croatian: Kako Lojuxta izgleda i sadržaj pakiranja
English: Patients with rare hereditary problems of galactose intolerance, total-lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja galaktoze, potpunim nedostatkom laktaze ili malapsorpcijom glukoze i galaktoze ne bi smjeli uzimati ovaj lijek.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 31 July 2013
Croatian: Datum prvog odobrenja: 31.srpnja 2013.
English: There is insufficient information to determine if Lojuxta requires dose adjustment in other races.
Croatian: Nema dovoljno podataka da bi se moglo odrediti zahtijeva li Lojuxta prilagodbu doze u pripadnika drugih rasa.
English: Efficacy phase weeks 0-26
Croatian: Faza ispitivanja djelotvornosti od 0. do 26. tjedna
English: Prescribers are encouraged to enrol all patients treated with Lojuxta into a global registry.
Croatian: Liječnike koji propisuju lijek potiče se da sve bolesnike koji se liječe Lojuxtom uključe u globalni registar.
English: Hepatic events related to elevated aminotransferases and progressive liver disease
Croatian: Hepatički događaji povezani s povišenim aminotransferazama i progresivnom bolešću jetre
English: Administration with food may increase exposure to lomitapide.
Croatian: Primjena s hranom može povećati izloženost lomitapidu.
English: • paracetamol - to treat pain
Croatian: • paracetamol - protiv bolova
English: • triglycerides (fat carried in the blood)
Croatian: • triglicerida (masti koje se nalaze u krvi).
English: • if you have bowel problems or cannot absorb food from your bowel.
Croatian: • ako imate tegobe s crijevima ili se hrana ne može apsorbirati iz crijeva
English: The recommended starting dose is 5 mg once daily.
Croatian: Preporučena početna doza iznosi 5 mg jedanput na dan.
English: In this study, 10 patients experienced elevations in AST and/or ALT >3 x ULN (see Table 6).
Croatian: U ovom ispitivanju 10 bolesnika imalo je povišenje AST i/ili ALT > 3 x GGN (vidjeti Tablicu 6).
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Croatian: Ako vam je Vaš liječnik rekao da ne podnosite neke šećere, obratite se svom liječniku prije nego uzmete ovaj lijek.
English: Cmax and AUC were increased following either a high-fat meal (77% and 58%, respectively) or low fat meal (70% and 28%, respectively).
Croatian: Vrijednosti Cmax i AUC povećale su se i nakon obroka s visokim udjelom masti (77% odnosno 58%) i nakon obroka s niskim udjelom masti (70% odnosno 28%).
English: There is limited experience with lomitapide in patients aged 65 years or older.
Croatian: Iskustvo s lomitapidom u bolesnika u dobi od 65 godina ili starijih je ograničeno.
English: The dose should be escalated gradually to minimise the incidence and severity of gastrointestinal adverse reactions and aminotransferase elevations.
Croatian: Dozu treba povećavati postupno kako bi se minimizirale incidencija i težina gastrointestinalnih nuspojava i porast aminotransferaza.
English: • Advice on escalating Lojuxta dose gradually to improve tolerability of the medicine;
Croatian: • savjet o postupnom povećanju doze Lojuxte kako bi se poboljšala podnošljivost lijeka;
English: • To evaluate whether prescribers of lomitapide are following the screening and monitoring recommendations as specified in the product information and the educational materials.
Croatian: • Procijeniti pridržavaju li se liječnici koji propisuju lomitapid preporuka za probir i nadzor kako je to navedeno u informacijama o lijeku i edukacijskim materijalima.
English: You may in some cases experience loss of fluids/dehydration, e.g. in case of vomiting, nausea and diarrhoea.
Croatian: U nekim slučajevima može doći do gubitka tekućine/dehidracije, npr. u slučaju povraćanja, mučnine ili proljeva.
English: Additional contraceptive measures should be used until resolution of symptoms (see section 4.5).
Croatian: Potrebne su dodatne mjere kontracepcije do nestanka simptoma (vidjeti dio 4.5).
English: During the first year, measure liver-related tests (ALT and AST, at a minimum) prior to each increase in dose or monthly, whichever occurs first.
Croatian: Tijekom prve godine potrebno je kontrolirati jetrene nalaze (barem ALT i AST) prije svakog povećanja doze ili jednom mjesečno, što god je prije.
English: • To lower the chance of stomach problems, you must stay on a low-fat diet whilst taking this medicine.
Croatian: • Da biste smanjili vjerojatnost želučanih tegoba morate se pridržavati dijete s malim udjelom masti dok uzimate ovaj lijek.
English: Decreased red blood cell parameters as well as poikilocytosis and/or anisocytosis were observed in dogs.
Croatian: Snižene vrijednosti crvenih krvnih stanica te poikilocitoza i/ili anizocitoza opaženi su u pasa.
English: Difficulty controlling INR contributed to early discontinuation from the Phase 3 study for one of five patients taking concomitant warfarin.
Croatian: Teškoće u kontroli INR-a pridonijele su prijevremenom prekidu sudjelovanja u ispitivanju faze 3 jednog od pet bolesnika koji su istodobno uzimali varfarin.
English: • loss of fluid that may cause headache, dry mouth, dizziness, tiredness or unconsciousness
Croatian: • gubitak tekućine koji može izazvati glavobolju, suha usta, omaglicu, umor ili nesvjesticu
English: Age and gender
Croatian: Dob i spol
English: Grapefruit juice
Croatian: Sok od grejpa
English: • dizziness, headache, migraine
Croatian: • omaglica, glavobolja, migrena
English: The clinical studies supporting the safety and efficacy of lomitapide in HoFH would have been unlikely to detect this adverse outcome given their size and duration.
Croatian: Nije vjerojatno da bi klinička ispitivanja koja podupiru sigurnost i djelotvornost lomitapida u bolesnika s HoFH-om, detektirala taj štetni ishod s obzirom na veličinu njihova uzorka i trajanje.
English: HMG-CoA Reductase Inhibitors (“Statins”): Lomitapide increases plasma concentrations of statins.
Croatian: Inhibitori reduktaze HMG-CoA („statini“): Lomitapid povećava plazmatske koncentracije statina.
English: These changes are secondary to the mechanism of action of lomitapide.
Croatian: Te su promjene posljedica mehanizma djelovanja lomitapida.
English: If aminotransferase levels do not fall below 3x ULN within approximately 4 weeks refer the patient to a hepatologist for further investigation.
Croatian: Ako vrijednosti aminotransferaza ne padnu ispod 3 x GGN unutar približno 4 tjedna, uputite bolesnika hepatologu radi dodatne obrade.
English: The mean dose of lomitapide was 45 mg at Week 26 and 40 mg at Week 78.
Croatian: Srednja doza lomitapida iznosila je 45 mg u 26. tjednu i 40 mg u 78. tjednu.
English: Focal hepatic fibrosis was observed in males and females and hepatic cystic degeneration was observed in males only.
Croatian: Fokalna fibroza jetre opažena je u mužjaka i ženki, a cistična degeneracija jetre samo u mužjaka.
English: Lojuxta has not been investigated in children less than 18 years of age.
Croatian: Lojuxta nije ispitivana u djece mlađe od 18 godina.
English: Contact your doctor immediately if you experience any unexplained muscle aches and pains, tenderness or weakness.
Croatian: Odmah se obratite liječniku ako osjetite bilo kakve neobjašnjive bolove u mišićima, ili slabost mišića.
English: Peak plasma concentrations of lomitapide were reached 4-8 hours following oral dosing.
Croatian: Vršne koncentracije lomitapida u plazmi dosegnute su 4 - 8 sati nakon peroralne primjene.
English: By blocking this protein, the medicine decreases the level of fats and cholesterol (lipids) in the blood.
Croatian: Blokiranjem te bjelančevine lijek snižava razinu masti i kolesterola (lipida) u krvi.
English: What Lojuxta is and what it is used for What you need to know before you take Lojuxta How to take Lojuxta
Croatian: Što je Lojuxta i za što se koristi Što morate znati prije nego počnete uzimati lijek Lojuxta Kako uzimati lijek Lojuxta
English: Work with a dietitian to learn what you can eat while taking Lojuxta.
Croatian: Savjetujte se sa stručnjakom za prehranu kako biste saznali što možete jesti dok uzimate lijek Lojuxta.
English: Other forms of primary hyperlipoproteinemia and secondary causes of hypercholesterolaemia (e.g., nephrotic syndrome, hypothyroidism) must be excluded.
Croatian: Moraju se isključiti drugi oblici primarne hiperlipoproteinemije kao i sekundarni uzroci hiperkolesterolemije (npr. nefrotski sindrom, hipotireoidizam).
English: Patients taking warfarin should undergo regular monitoring of the INR, especially after any changes in the dose of Lojuxta.
Croatian: U bolesnika koji uzimaju varfarin treba redovito kontrolirati INR, osobito nakon bilo kakve promjene doze lijeka Lojuxta.
English: • have had liver problems, including liver problems whilst taking other medicines.
Croatian: • ako ste imali tegoba s jetrom uključujući tegobe s jetrom dok ste uzimali druge lijekove.
English: • Repeat tests weekly and withhold dosing if there are signs of abnormal liver function (increase in bilirubin or INR), if aminotransferase levels rise above 5x ULN, or if aminotransferase levels do not fall below 3x ULN within approximately 4 weeks.
Croatian: • Ponavljati pretrage svaki tjedan i prekinuti terapiju ako postoje znakovi abnormalne funkcije jetre (povećanje bilirubina ili INR-a, ako se vrijednosti aminotransferaza povise 5 x GGN ili ako vrijednosti aminotransferaze ne padnu ispod 3 x GGN unutar približno 4 tjedna.
English: • Before starting treatment you should confirm you are not pregnant and are using effective contraception, as advised by your doctor.
Croatian: • Prije nego što započnete liječenje, morate potvrditi da niste trudni te da primjenjujete učinkovitu kontracepciju kako Vam je savjetovao liječnik.
English: This means that due to the rarity of the disease it has not been possible to obtain complete information on this medicinal product.
Croatian: To znači da s obzirom na malu učestalost bolesti nije bilo moguće doći do potpunih informacija o ovom lijeku.
English: A copy of the patient brochure and patient alert card shall be provided to all patients at the time Lojuxta treatment is initiated.
Croatian: Primjerak brošure za bolesnike i karticu s upozorenjima za bolesnika dobit će svi bolesnici u trenutku kada započnu liječenje Lojuxtom.
English: Lojuxta is used to treat adult patients with very high cholesterol because of a condition that runs in their families (homozygous familial hypercholesterolaemia or HoFH).
Croatian: Lojuxta se primjenjuje za liječenje odraslih bolesnika s vrlo visokom razinom kolesterola zbog stanja koje je nasljedno u njihovim obiteljima (homozigotna obiteljska hiperkolesterolemija ili HoFH).
English: Haemodialysis is unlikely to be beneficial given that lomitapide is highly protein bound.
Croatian: Nije vjerojatno da će hemodijaliza biti korisna jer se lomitapid u visokom postotku veže za proteine.
English: The following other side effects have also occurred:
Croatian: Zabilježene su također sljedeće nuspojave:
English: Entire trial weeks 0-78 N (%)
Croatian: Cjelokupno ispitivanje od 0. do 78. tjedna N (%)
English: • Take this medicine once a day at bedtime with a glass of water at least 2 hours after your evening meal (see section 2 under ‘Lojuxta with food, drink and alcohol').
Croatian: • Uzimajte ovaj lijek jedanput na dan u vrijeme odlaska na spavanje, s čašom vode barem 2 sata poslije večernjeg obroka (pogledajte dio 2 pod ‘Lojuxta s hranom, pićem i alkoholom').
English: PHARMACEUTICAL FORM AND CONTENTS 28 hard capsules
Croatian: OBLIK I SADRŽAJ 28 tvrdih kapsula
English: Hepatic steatosis and risk of progressive liver disease
Croatian: Hepatička steatoza i rizik od progresivne bolesti jetre
English: Lojuxta has not been investigated in patients aged 65 years or older.
Croatian: Lojuxta nije ispitivana u bolesnika u dobi od 65 godina ili starijih.
English: Lomitapide had no effect on reproductive function in female rats at doses up to 1 mg/kg or in male rats at doses up to 5 mg/kg.
Croatian: Lomitapid nije imao učinka na reproduktivnu funkciju ženki štakora pri dozama do 1 mg/kg ili mužjaka pri dozama do 5 mg/kg.
English: Lomitapide does not induce CYPs 1A2, 3A4, or 2B6, and does not inhibit CYPs 1A2, 2B6, 2C9, 2C19, 2D6, or 2E1.
Croatian: Lomitapid ne inducira CYP 1A2, 3A4 ili 2B6 te ne inhibira CYP 1A2, 2B6, 2C9, 2C19, 2D6 ili 2E1.
English: CYP isoforms 2E1, 1A2, 2B6, 2C8, and 2C19 are involved to a lesser extent and isoforms 2D6 and 2C9 are not involved in the metabolism of lomitapide.
Croatian: Izoforme CYP-a 2E1, 1A2, 2B6, 2C8 i 2C19 uključene su u manjem opsegu, a izoforme 2D6 i 2C9 nisu uključene u metabolizam lomitapida.
English: Information that the educational materials for patients included in the prescribers pack can be used for patient counselling.
Croatian: Informacije koje se odnose na bolesnike, a uključene su u materijal za liječnike koji propisuju lijek, mogu se iskoristiti za savjetovanje bolesnika.
English: • low red blood cell count (anaemia)
Croatian: • niski broj crvenih krvnih stanica (anemija)
English: Changes in lipids and lipoproteins through Week 26 and Week 78 of lomitapide treatment are presented in Table 5.
Croatian: Promjene lipida i lipoproteina do 26. tjedna i 78. tjedna u terapiji lomitapidom prikazane su u Tablici 5.
English: Other reactions reported by at least 20% of patients include abdominal pain, abdominal discomfort, abdominal distension, constipation, and flatulence.
Croatian: Druge nuspojave zabilježene u najmanje 20% bolesnika uključuju abdominalnu bol, abdominalnu nelagodu, abdominalnu distenziju, konstipaciju i flatulenciju.
English: Lojuxta may affect the way other medicines work.
Croatian: Lojuxta može utjecati na to kako djeluju drugi lijekovi.
English: • if you are pregnant, trying to get pregnant, or think you may be pregnant (see section 2 under ‘Pregnancy and breast-feeding').
Croatian: • ako ste trudni, pokušavate zatrudnjeti ili mislite da biste mogli biti trudni (pogledajte dio 2 pod ‘Trudnoća i dojenje').
English: • Warning about possible loss of effectiveness of oral contraceptives due to diarrhoea or vomiting and need for additional contraception until 7 days after resolution of symptoms;
Croatian: • Upozorenje o mogućem gubitku učinkovitosti peroralnih kontraceptiva zbog proljeva ili povraćanja, i o potrebi za dodatnom kontracepcijom još 7 dana nakon prestanka simptoma.
English: Data in the pivotal clinical study were analysed with respect to the impact of potential covariates on lomitapide exposure.
Croatian: Podaci pivotalnog kliničkog ispitivanja analizirani su s obzirom na utjecaj potencijalnih kovarijanata na izloženost lomitapidu.
English: It is important to avoid dehydration by drinking enough fluids (see section 4).
Croatian: Važno je izbjeći dehidraciju uzimanjem dovoljne količine tekućine (vidjeti dio 4).
English: Pharmacotherapeutic group: Lipid modifying agents, other lipid modifying agents, ATC code: C10AX12
Croatian: Farmakoterapijska skupina: pripravci koji modificiraju lipide, drugi pripravci koji modificiraju lipide, ATK oznaka: C10AX12
English: Patients taking Lojuxta should avoid consumption of grapefruit juice.
Croatian: Bolesnici koji uzimaju Lojuxtu trebaju izbjegavati konzumaciju soka od grejpa.
English: • vomiting blood
Croatian: • povraćanje krvi