FrancophonIA/ELRC3.0 huggingface dataset:
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Avastin 25 mg/ml concentrate for solution for infusion Bevacizumab
Slovenian: IME ZDRAVILA IN POT(I) UPORABE Avastin 25 mg/ml koncentrat za raztopino za infundiranje bevacizumab i.v.
English: Rate (n) p-value
Slovenian: p-vrednost (eksplorativna)
English: • stomach and intestinal disorder,
Slovenian: bolečine v trebuhu perforacija črevesja,
English: Table 11 Efficacy results for study AVF3694g: - Capecitabinea and Avastin/Placebo (Cap + Avastin/Pl)
Slovenian: Rezultati učinkovitosti preskušanja AVF3694g: kapecitabina in zdravilo
English: (p-value5 <0.0001)
Slovenian: (vrednost p5 < 0,0001)
English: Hazard ratio (95% CI) > 12 months (n=282) Median
Slovenian: 6-12 mesecev (n = 202) mediana razmerje ogroženosti (95-% interval zaupanja) > 12 mesecev (n = 282) mediana razmerje ogroženosti (95-% interval zaupanja)
English: Patients treated for persistent, recurrent, or metastatic cervical cancer with Avastin are at increased risk of fistulae between the vagina and any part of the GI tract (Gastrointestinal-vaginal fistulae).
Slovenian: Bolnice z rakom materničnega vratu, pri katerih je bolezen prisotna tudi po zaključenem primarnem zdravljenju, se je ponovila ali je metastatska, in se zdravijo z zdravilom Avastin, imajo večje tveganje za nastanek fistule med nožnico in katerim koli delom prebavil (fistule med prebavili in nožnico).
English: Severe reactions are defined as adverse events with at least a 2% difference compared to the control arm in clinical studies for NCI-CTCAE Grade 3-5 reactions.
Slovenian: Hudi neželeni učinki so tisti neželeni učinki stopnje 3 do 5 po lestvici NCI-CTCAE, ki so se pojavili z najmanj 2-% razliko v primerjavi s kontrolno skupino v kliničnih preskušanjih.
English: GENERAL CLASSIFICATION FOR SUPPLY Medicinal product subject to medical prescription
Slovenian: Vpliv bevacizumaba na farmakokinetiko drugih zdravil za zdravljenje novotvorb
English: Relative to control arm
Slovenian: a glede na kontrolno skupino
English: Hypersensitivity, infusion reactions a,b,c
Slovenian: reakcije pri infundiranjua,b,c
English: Wound healing (see section 4.4)
Slovenian: Celjenje ran (glejte poglavje 4.4)
English: Pulmonary embolism, Epistaxis, Dyspnoea, Hypoxia
Slovenian: pljučna embolija, hipoksija, disfonijaa pljučna hipertenzijaa, perforacija nosnega pretinaa
English: Patients were randomised to paclitaxel alone (90 mg/m2 IV over 1 hour once weekly for three out of four weeks) or in combination with Avastin (10 mg/kg IV infusion every two weeks).
Slovenian: v 1 uri enkrat tedensko tri od štirih tednov) ali v skupino, ki je prejemala kombinacijo paklitaksela in zdravila Avastin (10 mg/kg z intravensko infuzijo vsaka dva tedna).
English: Progression-Free Survival Median (months)
Slovenian: Preživetje brez napredovanja bolezni mediana (meseci)
English: This was a Phase III randomised, controlled, open-label trial investigating Avastin 5.0 mg/kg every 2 weeks or 7.5 mg/kg every 3 weeks in combination with fluoropyrimidine-based chemotherapy versus fluoropyrimidine-based chemotherapy alone in patients with mCRC who have progressed on a firstline bevacizumab-containing regimen.
Slovenian: ML18147 To je bilo randomizirano, kontrolirano, odprto preskušanje faze III, s katerim so pri bolnikih z metastatskim rakom debelega črevesa in danke, pri katerih je po prvi liniji zdravljenja z bevacizumabom prišlo do napredovanja bolezni, proučevali zdravilo Avastin v odmerku 5,0 mg/kg telesne mase vsaka 2 tedna ali v odmerku 7,5 mg/kg telesne mase vsake 3 tedne v kombinaciji s kemoterapijo, osnovano na fluoropirimidinu, v primerjavi s samostojno kemoterapijo na osnovi fluoropirimidina.
English: Gastrointestinal haemorrhages, including rectal bleeding and melaena have been reported in colorectal cancer patients, and have been assessed as tumour-associated haemorrhages.
Slovenian: Pri bolnikih z rakom debelega črevesa in danke so poročali o krvavitvah v prebavilih, vključno s krvavitvami iz danke in meleno.
English: An increased incidence of hypertension was observed in Avastin-treated patients.
Slovenian: Incidenca hipertenzije je bila večja pri bolnikih, zdravljenih z zdravilom Avastin.
English: Based on a substudy from NSABP C-08 with 295 patients d For additional information refer below within section "Further information on selected serious adverse reactions."
Slovenian: c Na podlagi podštudije NSABP C-08 z 295 bolnicami.
English: Possible risk factors include squamous cell histology, treatment with antirheumatic/anti-inflammatory substances, treatment with anticoagulants, prior radiotherapy, Avastin therapy, previous medical history of atherosclerosis, central tumour location and cavitation of tumours prior to or during therapy.
Slovenian: predhodna radioterapija, zdravljenjem z Avastinom, anamneza ateroskleroze, centralna lokalizacija tumorja in razpad tumorjev med zdravljenjem.
English: Bevacizumab in combination with fluoropyrimidine-based chemotherapy is indicated for treatment of adult patients with metastatic carcinoma of the colon or rectum.
Slovenian: 4.1 Terapevtske indikacije Bevacizumab je v kombinaciji s kemoterapijo na osnovi fluoropirimidina indiciran za zdravljenje odraslih bolnikov z metastatskim rakom debelega črevesa in danke.
English: 2 Investigator assessed PFS analysis with data cut-off date of 30 November 2010.
Slovenian: 1 Analiza podatkov preživetja brez napredovanja bolezni, ocenjenih s strani raziskovalca, zbranih do 30. novembra 2010.
English: • CPB15 arm: Five cycles of Avastin (15 mg/kg q3w started cycle 2) in combination with carboplatin (AUC 6) and paclitaxel (175 mg/m2) for 6 cycles followed by placebo alone, for a total of up to 15 months of therapy
Slovenian: · CPB15 skupina: pet ciklov zdravila Avastin (15 mg/kg telesne mase enkrat na 3 tedne, z začetkom v ciklu 2) v kombinaciji s karboplatinom (AUC 6) in 6 cikli paklitaksela
English: A reduction of circulating VEGF concentration has been demonstrated following intravitreal antiVEGF therapy.
Slovenian: Po intravitrealnem zdravljenju z zaviralci VEGF se koncentracija VEGF v plazmi zmanjša.
English: Hazard ratio (95% CI)
Slovenian: Razmerje ogroženosti (95-% IZ)
English: The results for all secondary endpoints (investigator assessed EFS, and ORR and OS) were consistent in showing no improvement associated with the addition of bevacizumab to the RT/T arm compared with the RT/T arm alone.
Slovenian: (preživetje brez dogodka po oceni raziskovalca, delež celokupnega odziva in celokupno preživetje) so bili skladni in niso pokazali izboljšanja, povezanega z dodatkom bevacizumaba v skupini, zdravljeni z radioterapijo in temozolomidom, v primerjavi s skupino, zdravljeno samo z radioterapijo in temozolomidom.
English: Elderly patients
Slovenian: Število bolnikov
English: The primary efficacy variable of the trial was overall survival.
Slovenian: Primarni cilj preskušanja in merilo za učinkovitost zdravila je bilo celokupno preživetje.
English: Table 1 provides all adverse reactions by frequency that were determined to have a causal relationship with Avastin through:
Slovenian: Za te neželene učinke so določili, da imajo vzročno povezavo z zdravilom Avastin:
English: It should not be administered as an intravenous push or bolus.
Slovenian: Zdravila se ne sme dajati kot hitro infuzijo ali bolus.
English: Randomised patients stage III optimally debulked disease 2,3
Slovenian: Randomizirane bolnice z optimalno citoredukcijo, stadija III
English: The recommended dose of Avastin is 10 mg/kg of body weight given once every 2 weeks as an intravenous infusion.
Slovenian: Priporočeni odmerek zdravila Avastin je 10 mg/kg telesne mase v enkratnem odmerku vsaka 2 tedna, v obliki intravenske infuzije.
English: • The chosen chemotherapy was combined with bevacizumab 10 mg/kg IV every 2 weeks (or bevacizumab 15 mg/kg every 3 weeks if used in combination with topotecan 1.25 mg/m2 on Days 1-5 every 3 weeks).
Slovenian: · skupina s kemoterapijo in bevacizumabom: · izbrano kemoterapijo so kombinirali z bevacizumabom, danim intravensko, v odmerku 10 mg/kg vsake 2 tedna (ali bevacizumabom v odmerku 15 mg/kg vsake 3
English: In one clinical trial evaluating Avastin in combination with 5-fluorouracil/folinic acid, AVF2192g, patients with metastatic colorectal cancer who were not candidates for treatment with irinotecan were included.
Slovenian: Bolniki z metastatskim rakom debelega črevesa in danke, ki niso bili primerni za zdravljenje z irinotekanom, so bili vključeni v klinično preskušanje AVF2192g, ki je ocenjevalo zdravilo Avastin v kombinaciji s 5-fluorouracilom oziroma folinsko kislino.
English: You may be advised to have a dental check-up before you start treatment with Avastin.
Slovenian: Pred začetkom zdravljenja z zdravilom Avastin boste morda morali opraviti pregled zob.
English: In NSABP C-08, a phase III trial of Avastin in adjuvant treatment of patients with colon cancer, the incidence of new cases of ovarian failure, defined as amenorrhoea lasting 3 or more months, FSH level ≥ 30 mIU/mL and a negative serum β-HCG pregnancy test, has been evaluated in 295 premenopausal women.
Slovenian: Za okvaro jajčnikov so upoštevali amenorejo, ki traja 3 mesece ali več, vrednosti FSH ≥ 30 mi.e./ml in negativen test nosečnosti (negativen serumski β-HCG).
English: The majority of patients included in the study were White (96%), the median age was 57 years in both treatment arms, 25% of patients in each treatment arm were 65 years of age or over, and approximately 50% of patients had an ECOG PS of 1; 7% of patients in each treatment arm had an
Slovenian: 25 % bolnic v vsaki skupini je bilo starih 65 let ali več in približno 50 % bolnic je imelo oceno stanja zmogljivosti (PS, performance status) po ECOG (Eastern Cooperative Oncology Group) 1; 7 %
English: A total of 116 patients were randomised to receive bevacizumab 3 mg/kg every 2
Slovenian: Skupno so 116 bolnikov randomizirali v skupino, ki je prejemala 3 mg/kg bevacizumaba na 2 tedna (n = 39), v skupino, ki je prejamala 10 mg/kg bevacizumaba na 2 tedna
English: From a clinical trial in patients with persistent, recurrent, or metastatic cervical cancer (study GOG0240), grade 3-5 venous thromboembolic events have been reported in up to 15.6% of patients treated with Avastin in combination with paclitaxel and cisplatin compared with up to 7.0% of patients treated with paclitaxel and cisplatin.
Slovenian: so o venskih trombemboličnih dogodkih stopnje 3 do 5 poročali pri do 15,6 % bolnic, ki so prejemale zdravilo Avastin v kombinaciji s paklitakselom in cisplatinom, in pri do 7,0 % bolnic, ki so prejemale paklitaksel in cisplatin.
English: METHOD OF ADMINISTRATION For intravenous use after dilution
Slovenian: Za intravensko uporabo po razredčitvi
English: ● if you need to undergo an invasive dental treatment or dental surgery, tell your dentist that you are being treated with Avastin, in particular when you are also receiving or have received an injection of bisphosphonate into your blood.
Slovenian: Preden začnete zdravljenje z zdravilom Avastin ali med zdravljenjem z njim: · svojemu zdravniku in zobozdravniku nemudoma povejte, če imate ali ste imeli bolečine v ustih,
English: Overall response rate Rate (percent) 95% CI p-value
Slovenian: Odgovor na zdravljenje delež (odstotki) 95-% interval zaupanja p-vrednost
English: Vascular disorders Renal thrombotic microangiopathy, which may be clinically manifested as proteinuria (not known) with or without concomitant sunitinib use.
Slovenian: Žilne bolezni renalna trombotična mikroangiopatija, ki se lahko klinično izrazi kot proteinurija (ni znana) pri sočasni uporabi sunitiniba ali brez; za dodatne informacije glede proteinurije glejte poglavje 4.4 in odstavek Proteinurija v poglavju 4.8
English: The efficacy results are presented in Table 15 Table 15 Efficacy results for trial BO17705
Slovenian: Rezultati učinkovitosti preskušanja BO17705 BO17705
English: Recto-vaginal fistulae are the most common fistulae in the GI-vaginal fistula category.
Slovenian: e Rektovaginalne fistule so najpogostejše fistule v skupini fistul med prebavili in nožnico.
English: Gall bladder perforation (not known)
Slovenian: pljučna hipertenzija (ni znana)
English: Treatment with Avastin at 15 mg/kg every 3 weeks in combination with chemotherapy (carboplatin and paclitaxel) for 6 and up to 8 cycles, followed by Avastin until disease progression or unacceptable toxicity resulted, when data were derived from eCRF, in a clinically meaningful and statistically significant improvement in OS compared to treatment with carboplatin and paclitaxel alone.
Slovenian: Izsledki (po zbranih podatkih iz eCRF) so pokazali klinično pomembno in statistično značilno podaljšanje celokupnega preživetja pri skupini, ki je prejemala zdravilo Avastin v odmerku 15 mg/kg vsake 3 tedne v kombinaciji s kemoterapijo (karboplatinom in paklitakselom) od 6 do največ 8 ciklov, ki mu je sledilo zdravilo Avastin do napredovanja bolezni ali nesprejemljive toksičnosti, v primerjavi z dajanjem samo karboplatina in paklitaksela.
English: ● If you get any side effects, talk to your doctor, pharmacist or nurse.
Slovenian: · Če opazite kateri koli neželeni učinek, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
English: Avastin is also used for treatment of adult patients with advanced kidney cancer.
Slovenian: Zdravilo Avastin uporabljamo tudi za zdravljenje odraslih bolnikov z napredovalim rakom ledvičnih celic.
English: Prior radiation is a major risk factor for the development of GI-vaginal fistulae and all patients with GIvaginal fistulae had a history of prior radiation.
Slovenian: Predhodno obsevanje je velik dejavnik tveganja za nastanek fistule med prebavili in nožnico; vse bolnice s fistulo med prebavili in nožnico so bile predhodno obsevane.
English: Pulmonary haemorrhage/ Haemoptysisb,d,
Slovenian: Srčne bolezni kongestivno srčno popuščanjeb,d,
English: Anaemia, Lymphopenia
Slovenian: letargija, vnetje sluznic
English: Cases of Osteonecrosis of the Jaw (ONJ) have been reported in patients treated with Avastin, most of which occurred in patients who had identified risk factors for ONJ, in particular exposure to intravenous bisphosphonates and/or a history of dental disease requiring invasive dental procedures (see also section 4.4)
Slovenian: zlasti izpostavljenost intravenskim difosfonatom in/ali anamneza zobne bolezni, ki je zahtevala invazivne zobozdravstvene posege (glejte tudi poglavje 4.4)
English: Congestive heart failure a,b
Slovenian: Srčne bolezni kongestivno srčno popuščanjea,b,
English: Paclitaxel 175 mg/m2 IV over 3 hours on Day 1 and cisplatin 50 mg/m2 IV on Day 2 (q3w); or Paclitaxel 175 mg/m2 IV over 3 hours on Day 1 and cisplatin 50 mg/m2 IV on Day 1 (q3w)
Slovenian: Skupno 452 bolnic so randomizirali na prejemanje ene od naslednjih shem: · paklitaksel 135 mg/m2 intravensko v 24-urni infuziji 1. dan in cisplatin 50 mg/m2 intravensko 2. dan na 3 tedne, ali paklitaksel 175 mg/m intravensko v 3-urni infuziji 1. dan in cisplatin 50 mg/m intravensko
English: • Paclitaxel 80 mg/m2 as a 1-hour IV infusion on Days 1, 8, 15, and 22 every 4 weeks.
Slovenian: · skupina s samo kemoterapijo: · paklitaksel 80 mg/m2 z 1-urno intravensko infuzijo 1., 8., 15. in 22. dan vsake 4 tedne; · topotekan 4 mg/m2 s 30-minutno intravensko infuzijo 1., 8. in 15. dan vsake 4 tedne; lahko se daje tudi v odmerku 1,25 mg/m2 v 30 minutah od 1. do 5. dne vsake 3 tedne;
English: From a clinical trial in patients with persistent, recurrent, or metastatic cervical cancer (study GOG0240), grade 3-5 bleeding reactions have been reported in up to 8.3% of patients treated with Avastin in combination with paclitaxel and topotecan compared with up to 4.6% of patients treated with paclitaxel and topotecan.
Slovenian: so o krvavitvah stopnje 3 do 5 poročali pri do 8,3 % bolnic, ki so prejemale zdravilo Avastin v kombinaciji s paklitakselom in topotekanom, in pri do 4,6 % bolnic, ki so prejemale paklitaksel in topotekan.
English: These clinically significant adverse reactions were reported in clinical trials but the grade 3-5 reactions did not meet the threshold of at least a 2% difference compared to the control arm. Table 2 also includes clinically significant adverse reactions that were observed only in the postmarketing setting, therefore, the frequency and NCI-CTCAE grade is not known.These clinically significant reactions have therefore been included in Table 2 within the column entitled “Frequency Not Known.”
Slovenian: O teh klinično pomembnih neželenih učinkih so poročali v kliničnih preskušanjih, a neželeni učinki stopenj 3 do 5 niso dosegli meje - najmanj 2-% razlike v primerjavi s kontrolno skupino.
English: 400 mg/m2 IV bolus, 600 mg/m2 IV 22 h
Slovenian: 2 h 5-fluorouracil 400 mg/m2 i.v.
English: If not used immediately, in-use storage times and conditions are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C, unless dilution has taken place in controlled and validated aseptic conditions.
Slovenian: Hranjenje navadno ne sme biti daljše od 24 ur pri temperaturi 2 °C do
English: Renal impairment
Slovenian: Neodprta viala
English: Posterior Reversible Encephalopathy Syndrome (see section 4.4) There have been rare reports of Avastin-treated patients developing signs and symptoms that are consistent with PRES, a rare neurological disorder.
Slovenian: Kongestivno srčno popuščanje (glejte poglavje 4.8) Med kliničnimi preskušanji so poročali o neželenih učinkih, skladnih s kongestivnim srčnim popuščanjem.
English: The main secondary efficacy endpoint was progression-free survival (PFS).Results are presented in Table 22.
Slovenian: Glavni sekundarni opazovani dogodek učinkovitosti je bil preživetje brez napredovanja bolezni (PFS).
English: Number of patients Progression-free survival Median (months) Hazard ratio
Slovenian: Preživetje brez napredovanja bolezni mediana (meseci) razmerje ogroženosti
English: The number of infusions that you receive will depend on how you are responding to treatment; you should continue to receive this medicine until Avastin fails to stop your tumour growing.
Slovenian: Število infuzij, ki jih boste prejeli, je odvisno od vašega odziva na zdravljenje.
English: ● if you have or have had pain in the mouth, teeth and/or jaw, swelling or sores inside the mouth, numbness or a feeling of heaviness in the jaw, or loosening of a tooth tell your doctor and dentist immediately.
Slovenian: zobeh in/ali čeljusti, otekline ali mehurji v ustih, otrplost ali občutek teže v čeljusti, ali če se vam je razmajal zob; · pred invazivnimi posegi v zobozdravstvu in oralni kirurgiji povejte svojemu zobozdravniku, da se zdravite z zdravilom Avastin, še posebej, če prejemate ali ste prejemali injekcije difosfonata v kri.
English: Hypertension a,b
Slovenian: hemoptizaa,b,
English: Paclitaxel (n=243)
Slovenian: paklitaksel (n = 243)
English: The trial met its primary objective of OS improvement.
Slovenian: Preskušanje je doseglo primarni cilj: podaljšanje celokupnega preživetja.
English: including pulmonary embolism (NCI-CTCAE v.3).
Slovenian: O venskih trombemboličnih neželenih učinkih stopnje 3 do 5 (NCI-CTCAE v.3) so poročali pri do
English: Topotecan+ Paclitaxel vs. Cisplatin+ Paclitaxel
Slovenian: Topotekan + paklitaksel proti cisplatin + paklitaksel
English: In addition, a prespecified analysis of the data censoring for CA-125 progression events was conducted, as well as an independent review of PFS as determined by radiological scans.
Slovenian: Opravljen je bil tudi neodvisni pregled preživetja brez napredovanja bolezni, ki je bilo določeno z radiološkimi posnetki.
English: • GOG-0213 evaluated the efficacy and safety of bevacizumab in combination with carboplatin and paclitaxel, followed by bevacizumab as a single agent in patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer.
Slovenian: · Preskušanje GOG-0213 je ocenjevalo učinkovitost in varnost bevacizumaba v kombinaciji s karboplatinom in paklitakselom, ki jim je sledil bevacizumab samostojno, pri bolnicah s ponovitvijo epitelijskega raka jajčnikov, karcinoma jajcevodov ali primarnega peritonealnega karcinoma, občutljivega na platino.
English: • CP arm: Carboplatin (AUC5) and paclitaxel (175 mg/m2 IV) every 3 weeks for 6 and up to 8 cycles.
Slovenian: Skupaj so randomizirali 673 bolnic v enakih deležih v naslednji dve skupini: · skupina CP: karboplatin (AUC5) in paklitaksel (175 mg/m2 intravensko) vsake 3 tedne, od 6 do največ 8 ciklov.
English: Effect of antineoplastic agents on bevacizumab pharmacokinetics No clinically relevant interaction of co-administered chemotherapy on bevacizumab pharmacokinetics was observed based on the results of population pharmacokinetic analyses.
Slovenian: Populacijske farmakokinetične analize so pokazale, da klinično pomembnega medsebojnega delovanja sočasno dane kemoterapije na farmakokinetiko bevacizumaba ni.
English: b
Slovenian: V
English: <2D barcode carrying the unique identifier included.>
Slovenian: EDINSTVENA OZNAKA - DVODIMENZIONALNA ČRTNA KODA Vsebuje dvodimenzionalno črtno kodo z edinstveno oznako.
English: In study BO25041 of Avastin added to postoperative radiation therapy (RT) with concomitant and adjuvant temozolomide in paediatric patients with newly diagnosed supratentorial, infratentorial, cerebellar, or peduncular high-grade glioma, the safety profile was comparable with that observed in other tumour types in adults treated with Avastin.
Slovenian: V študiji BO25041 z zdravilom Avastin, dodanim pooperativni radioterapiji s sočasno in adjuvantno uporabo temozolomida pri pediatričnih bolnikih z novo diagnosticiranim supratentorialnim,
English: In a trial of patients with persistent, recurrent or metastatic cervical cancer, the incidence of GI-vaginal fistulae was 8.3% in Avastin-treated patients and 0.9% in control patients, all of whom had a history of prior pelvic radiation.
Slovenian: Fistule med prebavili in nožnico v študiji GOG-0240 V preskušanju pri bolnicah z rakom materničnega vratu, pri katerih je bila bolezen prisotna tudi po zaključenem primarnem zdravljenju, se je ponovila ali je bila metastatska, je bila incidenca fistul med prebavili in nožnico 8,3 % med prejemnicami zdravila Avastin in 0,9 % pri bolnicah v kontrolni skupini; vse te bolnice so imele v anamnezi obsevanje medeničnega predela.
English: CT (n=144)
Slovenian: kemoterapija (n = 144)
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON
Slovenian: PODATKI NA ZUNANJI OVOJNINI Škatla
English: Thromboembolism (arterial)b,d, Haemorrhageb,d,
Slovenian: Žilne bolezni hipertenzijaa,b arterijska trombembolijaa,b, krvaviteva,b,
English: You must not use this medicine if you are pregnant.
Slovenian: Nosečnost, dojenje in plodnost Če ste noseči, tega zdravila ne smete prejemati.
English: If this happens you should talk to your doctor, pharmacist or nurse immediately.
Slovenian: Če se to zgodi, se takoj posvetujte s svojim zdravnikom,
English: • CP arm: Carboplatin (AUC 6) and paclitaxel (175 mg/m2) for 6 cycles of 3 weeks duration
Slovenian: · skupina CPB: karboplatin (AUC5) in paklitaksel (175 mg/m2 intravensko) ter sočasno zdravilo
English: ● Superiority of the Avastin-containing arms versus the chemotherapy alone arms in the overall comparison was demonstrated in terms of progression-free survival in the ITT population (Table 7).
Slovenian: · V populaciji bolnikov, ki so jo nameravali zdraviti (ITT - intent to treat population), je bilo v celokupni primerjavi glede na preživetje brez napredovanja bolezni dokazano, da so skupine, ki so prejemale zdravilo Avastin, superiorne skupinam, ki so prejemale samo kemoterapijo (preglednica 7).
English: When used for patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer, it will be administered in combination with carboplatin and paclitaxel.
Slovenian: Kadar ga uporabljamo pri bolnicah z epitelijskim rakom jajčnikov, karcinomom jajcevodov ali primarnim rakom potrebušnice,
English: What Avastin looks like and contents of the pack Avastin is a concentrate for solution for infusion.
Slovenian: Izgled zdravila Avastin in vsebina pakiranja