FrancophonIA/ELRC3.0 huggingface dataset:
English: The European Commission granted a marketing authorisation valid throughout the European Union for Aerius on 15 January 2001.
Croatian: Europska komisija izdala je odobrenje za stavljanje u promet koje je za lijek Aerius na snazi u Europskoj uniji od 15. siječnja 2001.
English: Other information about Aerius
Croatian: Ostale informacije o lijeku Aerius
English: This is a summary of the European public assessment report (EPAR) for Aerius.
Croatian: Ovo je sažetak europskoga javnog izvješća o ocjeni dokumentacije (EPAR) o lijeku Aerius.
English: In adults and adolescents, the most common side effects are fatigue (tiredness; 1.2%), dry mouth (0.8%) and headache (0.6%).
Croatian: U odraslih osoba i adolescenata, najčešće nuspojave su iscrpljenost (umor; 1,2 %), suha usta (0,8 %) i glavobolja (0,6 %).
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Aerius.
Croatian: Objašnjava kako je Odbor za lijekove za humanu uporabu (CHMP) ocijenio lijek da bi donio svoje mišljenje u korist izdavanja odobrenja za stavljanje lijeka u promet te preporuke o uvjetima za primjenu lijeka Aerius.
English: In all studies, the effectiveness of Aerius was compared with that of placebo (a dummy treatment).
Croatian: U svim ispitivanjima, djelotvornost lijeka Aerius uspoređena je s onom placeba (liječenja bez djelatne tvari).
English: Aerius is a medicine containing the active substance desloratadine.
Croatian: Aerius je lijek koji sadrži djelatnu tvar desloratadin.
English: In the two studies in urticaria, the decrease in symptom score after six weeks of treatment with Aerius was 58 and 67%, compared with 40 and 33% in placebo-treated patients.
Croatian: U dva ispitivanja kod urtikarije, smanjenje u rezultatu simptoma nakon šest tjedana terapije lijekom Aerius bilo je 58 do 67 %, u usporedbi sa 40 i 33 % u bolesnika liječenih placebom.
English: Aerius has been studied in a total of eight studies involving about 4,800 adult and adolescent patients with allergic rhinitis (including four studies in seasonal allergic rhinitis, and two studies in patients who also had asthma).
Croatian: Aerius je ispitivan u ukupno osam ispitivanja koja su obuhvatila 4 800 odraslih osoba i adolescenata s alergijskim rinitisom (uključujući četiri ispitivanja u slučaju sezonskog alergijskog rinitisa i dva ispitivanja u bolesnika koji su također imali astmu).
English: The active substance in Aerius, desloratadine, is an antihistamine.
Croatian: Djelatna tvar lijeka Aerius, desloratadin, je antihistamin.
English: In allergic rhinitis, looking at the results of all studies taken together, two weeks of treatment with 5 mg Aerius led to an average decrease in symptom score of 25 to 32%, compared with a decrease of 12 to 26% in the patients receiving placebo.
Croatian: U slučaju alergijskog rinitisa, promatrajući rezultate svih ispitivanja zajedno, nakon dvotjedna terapije lijekom Aerius od 5 mg došlo je do prosječnog smanjenja simptoma od 25 do 32 %, u usporedbi sa smanjenjem od 12 do 26 % u bolesnika koji su primali placebo.
English: Aerius is used to relieve the symptoms of allergic rhinitis (inflammation of the nasal passages caused by an allergy, for example, hay fever or allergy to dust mites) or urticaria (a skin condition caused by an allergy, with symptoms including itching and hives).
Croatian: Aerius se koristi za ublažavanje simptoma alergijskog rinitisa (upale nosnih putova uzrokovane alergijom, primjerice alergijom na sijeno ili alergijom na prašinske grinje) ili urtikarije (stanje kože uzrokovano alergijom, sa simptomima koji uključuju svrbež i osip).
English: What is the risk associated with Aerius?
Croatian: Koji su rizici povezani s lijekom Aerius?
English: What is Aerius?
Croatian: Što je Aerius?
English: The CHMP decided that Aerius's benefits are greater than its risks for the relief of symptoms associated with allergic rhinitis or urticaria and recommended that it be given marketing authorisation.
Croatian: CHMP je odlučio da koristi lijeka Aerius premašuju s njim povezane rizike za ublažavanje simptoma povezanih s alergijskim rinitisom ili urtikarijom i preporučio je izdavanje odobrenja za stavljanje lijeka u promet.
English: The full EPAR for Aerius can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Croatian: Cjeloviti EPAR za lijek Aerius nalazi se na internetskim stranicama Agencije: ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports Više informacija o terapiji lijekom Aerius pročitajte u uputi o lijeku (također dio EPAR-a) ili se obratite svom liječniku ili ljekarniku.
English: Aerius must not be used in people who are hypersensitive (allergic) to desloratadine, loratadine or any of the other ingredients.
Croatian: Aerius se ne smije primjenjivati u osoba koje su preosjetljive (alergične) na desloratadin ili na bilo koju drugu pomoćnu tvar.
English: The effectiveness of Aerius was measured by looking at the change in the symptoms (nasal discharge, itching, sneezing and congestion) before and after two or four weeks of treatment.
Croatian: Djelotvornost lijeka Aerius mjerena je promatranjem promjena simptoma (iscjedak iz nosa, svrbež, kihanje i zatvor) prije i nakon dva ili četiri tjedna terapije.
English: Why has Aerius been approved?
Croatian: Zašto je Aerius odobren?
English: What is Aerius used for?
Croatian: Za što se Aerius koristi?
English: What benefit has Aerius shown during the studies?
Croatian: Koje su koristi lijeka Aerius utvrđene u ispitivanjima?
English: For the full list of all side effects reported with Aerius, see the package leaflet.
Croatian: Potpuni popis nuspojava zabilježenih pri primjeni lijeka Aerius potražite u uputi o lijeku.
English: How is Aerius used?
Croatian: Kako se Aerius koristi?
English: How does Aerius work?
Croatian: Kako djeluje Aerius?
English: How has Aerius been studied?
Croatian: Kako je Aerius ispitivan?
English: -1- - Synthetic peptide analogue of GnRF conjugated to a carrier protein of min. 300 µg per 2 ml dose
Croatian: -1- - Sintetički analog peptida GnRF-a konjugiranog u difterijski toksoid min.
English: You can take Micardis with or without food.
Croatian: Možete uzimati Micardis sa ili bez hrane.
English: It is important that you take Micardis every day until your doctor tells you otherwise.
Croatian: Važno je uzimati Micardis svaki dan, dok Vam liječnik ne kaže drugačije.
English: If you take more Micardis than you should
Croatian: Ako uzmete više Micardisa nego što ste trebali
English: Date of first authorisation: 16 December 1998 Date of last renewal: 16 December 2008
Croatian: Datum posljednje obnove odobrenja: 16. prosinca 2008.
English: What Micardis is and what it is used for
Croatian: Što je Micardis i za što se koristi
English: Micardis contains sorbitol.
Croatian: Micardis sadrži sorbitol.
English: Your doctor can tell you if you are at high risk for such events.
Croatian: Liječnik će Vam reći spadate li u rizičnu skupinu za takve događaje.
English: Other medicines and Micardis
Croatian: Drugi lijekovi i Micardis
English: If you have the impression that the effect of Micardis is too strong or too weak, talk to your doctor or pharmacist.
Croatian: Ako mislite da je učinak Micardisa prejak ili preslab, razgovarajte sa svojim liječnikom ili ljekarnikom.
English: What Micardis contains
Croatian: Što Micardis sadrži
English: Patients with rare hereditary problems of fructose intolerance should not take Micardis.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja fruktoze ne bi trebali uzimati Micardis.
English: Your doctor will normally advise you to stop taking Micardis before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Micardis.
Croatian: Liječnik će Vam obično savjetovati da prestanete uzimati Micardis prije nego ostanete trudni ili čim saznate da ste trudni te će Vam savjetovati uzimanje drugog lijeka umjesto Micardisa.
English: Talk to your doctor before taking Micardis if you are suffering or have ever suffered from any of the following conditions or illnesses:
Croatian: Obratite se svom liječniku prije nego uzmete Micardis ako imate ili ste ikada imali neko od sljedećih stanja ili bolesti:
English: There are no adequate data from the use of Micardis in pregnant women.
Croatian: Ne postoje odgovarajući podaci o primjeni Micardisa u trudnica.
English: Precautions to be taken before handling or administering the medicinal product.
Croatian: Mjere opreza koje je potrebno poduzeti prije rukovanja ili primjene lijeka.
English: This applies especially to the medicines listed below taken at the same time with Micardis:
Croatian: Ovo se osobito odnosi na lijekove koji su navedeni u nastavku, a uzimaju se istovremeno s Micardisom:
English: In case of surgery or anaesthesia, you should tell your doctor that you are taking Micardis.
Croatian: U slučaju kirurškog zahvata ili anestezije, trebate obavijestiti svog liječnika da uzimate Micardis.
English: Your doctor may need to change the dose of these other medicines or take other precautions.
Croatian: Liječnik će možda trebati promijeniti dozu ovih drugih lijekova ili poduzeti druge mjere opreza.
English: One blister contains 7 or 10 tablets.
Croatian: Jedan blister sadrži 7 tableta.
English: If you forget to take Micardis
Croatian: Ako ste zaboravili uzeti Micardis
English: What Micardis is and what it is used for What you need to know before you take Micardis How to take Micardis
Croatian: Što je Micardis i za što se koristi Što morate znati prije nego počnete uzimati Micardis Kako uzimati Micardis
English: The overall incidence of adverse reactions reported with telmisartan was usually comparable to placebo (41,4% vs 43.9 %) in controlled trials in patients treated for hypertension.
Croatian: Ukupna incidencija nuspojava zabilježenih s telmisartanom bila je uobičajeno usporediva s placebom (41,4 % u odnosu na 43,9 %) u kontroliranim ispitivanjima u bolesnika liječenih zbog hipertenzije.
English: Micardis is used to treat essential hypertension (high blood pressure) in adults.
Croatian: Micardis se primjenjuje u liječenju esencijalne hipertenzije (visoki krvni tlak) u odraslih osoba.
English: Some people feel dizzy or tired when taking Micardis.
Croatian: Neki ljudi osjećaju omaglicu ili umor kada uzimaju Micardis.
English: Talk to your doctor before taking Micardis:
Croatian: Obratite se svom liječniku prije nego uzmete Micardis:
English: Volume and/or sodium depletion should be corrected prior to administration of Micardis.
Croatian: Deplecija volumena i/ili natrija se mora korigirati prije primjene Micardisa.
English: D-55216 Ingelheim am Rhein Germany
Croatian: D-55216 Ingelheim am Rhein
English: Do not take Micardis
Croatian: Nemojte uzimati Micardis
English: Micardis may be less effective in lowering the blood pressure in black patients.
Croatian: Micardis može biti manje učinkovit u snižavanju krvnog tlaka u bolesnika crne rase.
English: You should consult with your doctor if you need to adjust the dose of your other medicine while taking Micardis.
Croatian: Potrebno je posavjetovati se s liječnikom ako trebate prilagodbu doze drugih lijekova koje uzimate istodobno s Micardisom.
English: There is no experience regarding the administration of Micardis in patients with recent kidney transplantation.
Croatian: Ne postoji iskustvo u vezi primjene Micardisa u bolesnika kojima je nedavno transplantiran bubreg.
English: Micardis is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Croatian: Micardis se ne preporučuje dojiljama te Vaš liječnik može odabrati drugo liječenje za Vas ako želite dojiti, osobito ako je Vaše dijete novorođenče ili je prerano rođeno.
English: When driving vehicles or operating machinery it should be taken into account that dizziness or drowsiness may occasionally occur when taking antihypertensive therapy such as Micardis.
Croatian: Prilikom upravljanja vozilima ili strojevima, povremeno može doći do pojave omaglice ili pospanosti, kada se uzima antihipertenzivna terapija poput Micardisa.
English: See also information under the heading “Do not take Micardis”.
Croatian: Vidjeti također informacije pod naslovom “Nemojte uzimati Micardis“
English: At the beginning of the preventive therapy with Micardis 80 mg, blood pressure should be frequently monitored.
Croatian: Na početku preventivnog liječenja s Micardisom od 80 mg, krvni tlak treba redovito pratiti.
English: Such conditions should be corrected before the administration of Micardis.
Croatian: Takva stanja moraju se korigirati prije primjene Micardisa.
English: Micardis belongs to a class of medicines known as angiotensin II receptor antagonists.
Croatian: Micardis pripada skupini lijekova poznatih kao antagonisti receptora angiotenzina II.
English: • Diuretics ('water tablets'), especially if taken in high doses together with Micardis, may lead to excessive loss of body water and low blood pressure (hypotension).
Croatian: • Diuretici ('tablete za mokrenje'), osobito ako se uzimaju visoke doze zajedno s Micardisom, mogu dovesti do prekomjernog gubitka vode u tijelu te niskog krvnog tlaka (hipotenzija).
English: Serious adverse drug reactions include anaphylactic reaction and angioedema which may occur rarely (≥1/10,000 to <1/1,000) , and acute renal failure.
Croatian: Teške nuspojave obuhvaćaju anafilaktičku reakciju i angioedem koji se mogu rijetko pojaviti (≥ 1/10 000 do < 1/1000) i akutno zatajenje bubrega.
English: 14 tablets 28 tablets 56 tablets 98 tablets
Croatian: 14 tableta 28 tableta 56 tableta 98 tableta
English: 10 rue Colonel Charbonneaux 51100 Reims
Croatian: Delpharm Reims S.A.S. 10 rue Colonel Charbonneaux 51100 Reims
English: The effect of Micardis may be reduced when you take NSAIDs (non steroidal anti-inflammatory medicines, e.g. aspirin or ibuprofen) or corticosteroids.
Croatian: Učinak Micardisa se može smanjiti kada uzimate NSAIL (nesteroidne protupalne lijekove, npr. aspirin ili ibuprofen) ili kortikosteroide.
English: Because no information is available regarding the use of Micardis during breast-feeding, Micardis is not recommended and alternative treatments with better established safety profiles during breastfeeding are preferable, especially while nursing a newborn or preterm infant.
Croatian: Budući da ne postoje dostupni podaci o primjeni Micardisa tijekom dojenja, primjena Micardisa se ne preporučuje i prednost se daje drugim lijekovima s bolje utvrđenim sigurnosnim profilima tijekom dojenja, osobito tijekom razdoblja dojenja novorođenčeta ili nedonoščeta.
English: Micardis may increase the blood pressure lowering effect of other medicines used to treat high blood pressure or of medicines with blood pressure lowering potential (e.g. baclofen, amifostine).
Croatian: Micardis može povećati učinak snižavanja krvnog tlaka drugih lijekova koji se primjenjuju u liječenju visokog krvnog tlaka ili lijekova s potencijalnim učincima na snižavanje krvnog tlaka (npr. baklofen, amifostin).
English: The safety and efficacy of Micardis in children and adolescents aged below 18 years have not been established.
Croatian: Sigurnost i djelotvornost Micardisa u djece i adolescenata mlađih od 18 godina nisu ustanovljene.
English: For reduction of cardiovascular events, the usual dose of Micardis is one 80 mg tablet once a day.
Croatian: Za smanjivanje kardiovaskularnih događaja, uobičajena doza Micardisa je jedna tableta od 80 mg, jedanput na dan.
English: Remove your Micardis tablet from the blister only directly prior to intake.
Croatian: Izvadite Micardis tabletu iz blistera neposredno prije unosa.
English: Micardis is also used to reduce cardiovascular events (i.e. heart attack or stroke) in adults who are at risk because they have a reduced or blocked blood supply to the heart or legs, or have had a stroke or have high risk diabetes.
Croatian: Micardis se također primjenjuje za smanjivanje kardiovaskularnih događaja (tj. srčanog udara ili moždanog udara) u rizičnih odraslih osoba koji imaju smanjenu ili prekinutu opskrbu krvlju srca ili nogu, ili su imali moždani udar, ili imaju šećernu bolest s visokim rizikom za oštećenje organa.
English: Micardis is not to be given to patients with cholestasis, biliary obstructive disorders or severe hepatic impairment (see section 4.3) since telmisartan is mostly eliminated with the bile.
Croatian: Micardis se ne smije davati bolesnicima s kolestazom, bilijarnom opstrukcijom ili teškim oštećenjem jetrene funkcije (vidjeti dio 4.3), s obzirom da se telmisartan uglavnom eliminira putem žuči.
English: Children and adolescents The use of Micardis in children and adolescents up to the age of 18 years is not recommended.
Croatian: Djeca i adolescenti Primjena Micardisa u djece i adolescenata do dobi od 18 godina se ne preporučuje.
English: Dual blockade of the renin-angiotensin-aldosterone system (RAAS)
Croatian: Dvostruka blokada renin-angiotenzin-aldosteronskog (RAAS)
English: The concomitant use of Micardis with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1).
Croatian: Istodobna primjena Micardisa s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem bubrega (GFR < 60 ml/min/1,73 m2) (vidjeti dijelove 4.5 i 5.1).
English: Symptomatic hypotension, especially after the first dose of Micardis, may occur in patients who are volume and/or sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea, or vomiting.
Croatian: Simptomatska hipotenzija, osobito nakon prve doze Micardisa, može se pojaviti u bolesnika koji imaju depleciju volumena i/ili natrija zbog snažne terapije diureticima, prehrane s ograničenim unosom soli, proljeva ili povraćanja.
English: Urinary tract infection including cystitis, upper respiratory tract infection including pharyngitis and sinusitis Sepsis including fatal outcome
Croatian: Infekcije mokraćnog sustava uključujući cistitis, infekcije gornjeg dišnog sustava uključujući faringitis i sinusitis Sepsa uključujući smrtni ishod
English: If you are intolerant to some sugars, consult your doctor before taking Micardis.
Croatian: Ako ne podnosite neke šećere, posavjetujte se sa svojim liječnikom prije uzimanja Micardisa.
English: In patients with mild to moderate hepatic impairment, the posology should not exceed 40 mg once daily (see section 4.4).
Croatian: U bolesnika s blagim do umjerenim oštećenjem jetrene funkcije doza ne smije prelaziti 40 mg jedanput na dan (vidjeti dio 4.4).
English: Dual blockade of RAAS through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is therefore not recommended (see sections 4.5 and 5.1).
Croatian: Dvostruka blokada RAAS-a kombiniranom primjenom ACE-inhibitora, blokatora angiotenzin II receptora ili aliskirena stoga se ne preporučuje (vidjeti dijelove 4.5 i 5.1).
English: Treatment of essential hypertension in adults.
Croatian: Hipertenzija Liječenje esencijalne hipertenzije u odraslih osoba.
English: Micardis is available in blister packs containing 14, 28, 56 or 98 tablets.
Croatian: Micardis je dostupan u blister pakiranjima od 14, 28, 56 ili 98 tableta.
English: Fertility In preclinical studies, no effects of Micardis on male and female fertility were observed.
Croatian: U nekliničkim ispitivanjima učinci Micardisa na plodnost muškaraca i žena nisu uočeni.
English: When Micardis is used in patients with impaired renal function, periodic monitoring of potassium and creatinine serum levels is recommended.
Croatian: Kada se Micardis primjenjuje u bolesnika s poremećenom funkcijom bubrega, preporučuje se povremeno pratiti vrijednosti kalija i kreatinina u serumu.
English: • if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Croatian: • Ako imate šećernu bolest ili oštećenu bubrežnu funkciju i liječite se lijekom za snižavanja krvnog tlaka koji sadrži aliskiren.
English: Rottendorf Pharma GmbH Ostenfelder Straße 51 - 61 59320 Ennigerloh Germany
Croatian: Rottendorf Pharma GmbH Ostenfelder Straße 51 - 61 59320 Ennigerloh Njemačka
English: What you need to know before you take Micardis
Croatian: Što morate znati prije nego počnete uzimati Micardis
English: PHARMACEUTICAL FORM AND CONTENTS Multipack comprising 4 packs, each containing 90 x 1 tablets
Croatian: 4. FARMACEUTSKI OBLIK I SADRŽAJ Višestruko pakiranje s 4 pakiranja, od kojih svako sadrži 90 x 1 tabletu.
English: **Cases of progressive scarring of lung tissue have been reported during intake of telmisartan.
Croatian: **Slučajevi progresivnog stvaranja ožiljaka u tkivu pluća (bolest plućnog intersticija) zabilježeni su tijekom uzimanja telmisartana.
English: Micardis blocks the effect of angiotensin II so that the blood vessels relax, and your blood pressure is lowered.
Croatian: Micardis blokira učinak angiotenzina II, tako da se krvne žile šire, a krvni tlak snižava.
English: 14 tablets 28 tablets 56 tablets 98 tablets 28 x 1 tablets 84 tablets 30 x 1 tablets 90 x 1 tablets
Croatian: 14 tableta 28 tableta 56 tableta 98 tableta 28 x 1 tableta 84 tablete 30 x 1 tableta 90 x 1 tableta
English: CLINICAL PARTICULARS 4.1 Therapeutic indications Hypertension
Croatian: 4.1 Terapijske indikacije
English: Micardis should be used only with caution in patients with mild to moderate hepatic impairment.
Croatian: Micardis se treba primjenjivati isključivo s oprezom u bolesnika s blagim do umjerenim oštećenjem jetrene funkcije.
English: Micardis is contraindicated in patients with severe hepatic impairment (see section 4.3).
Croatian: Micardis je kontraindiciran u bolesnika s teškim oštećenjem funkcije jetre (vidjeti dio 4.3).
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Unit dose blister
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP Blister djeljiv na jedinične doze
English: If any of the above applies to you, tell your doctor or pharmacist before taking Micardis.
Croatian: Ako se nešto od prethodno navedenog odnosi na Vas, obavijestite liječnika ili ljekarnika prije početka uzimanja Micardisa.
English: Possible side effects of Micardis
Croatian: Moguće nuspojave Micardisa
English: • If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take Micardis” and “Warning and precautions”).
Croatian: • Ako uzimate ACE-inhibitor ili aliskiren (vidjeti također informacije pod naslovima „Nemojte uzimati Micardis“ i „Upozorenja i mjere opreza“).
English: Бьорингер Ингелхайм РЦВ ГмбХ и Ко.
Croatian: Бьорингер Ингелхайм Фарма РЦВ ГмбХ и Ko.
English: • if you are taking any of the following medicines used to treat high blood pressure: - an ACE-inhibitor (for example enalapril, lisinopril, ramipril), in particular if you have diabetes-related kidney problems.
Croatian: • ako uzimate bilo koji od lijekova navedenih u nastavku, koji se koriste za liječenje visokog krvnog tlaka: - ACE-inhibitor (primjerice enalapril, lizinopril, ramipril), osobito ako imate bubrežne tegobe povezane sa šećernom bolešću. - aliskiren.
English: Micardis is available in blister packs containing 14, 28, 56, 84 or 98 tablets, in unit dose blister packs containing 28 x 1, 30 x 1 or 90 x 1 tablets or in multipacks containing 360 (4 packs of 90 x 1) tablets.
Croatian: Micardis je dostupan u blister pakiranjima od 14, 28, 56, 84 ili 98 tableta i blisterima djeljivim na jedinične doze s 28 x 1, 30 x 1 ili 90 x 1 tableta ili u višestrukom pakiranju koje sadrži 360 (4 pakiranja od 90 x 1) tableta.
English: • type 2 diabetes mellitus with documented target organ damage
Croatian: • dijabetes melitus tip 2 s dokazanim oštećenjem ciljnih organa 4.2 Doziranje i način primjene