FrancophonIA/ELRC3.0 huggingface dataset:
English: In the event of a system failure or a wall-outlet power failure, a backup battery power supply and reserve nitric oxide delivery system should be available.
Croatian: Za slučaj prekida rada sustava ili nestanka električne energije mora biti dostupno rezervno baterijsko napajanje i rezervni sustav za dopremu dušikovog (II) oksida.
English: There are no adequate data from the use of nitric oxide in pregnant women.
Croatian: Ne postoje odgovarajući podaci o primjeni dušikovog (II) oksida u trudnica.
English: Some medicines can affect the ability of blood to carry oxygen.
Croatian: Neki lijekovi mogu utjecati na sposobnost prenošenja kisika putem krvi.
English: Newborn infants, infants and toddlers, children and adolescents, ages 0-17 years The starting dose of inhaled nitric oxide is 10 ppm(part per million) of inhaled gas.
Croatian: Novorođenčad, dojenčad i mala djeca, djeca i adolescenti, u dobi od 0 do 17 godina Početna doza za inhalaciju dušikovog (II) oksida iznosi 10 ppm (dijelova na milijun) udahnutog plina.
English: The clinical significance of the chemical reactivity of nitric oxide in tissue is unknown.
Croatian: Nije poznat klinički značaj kemijske reaktivnosti dušikovog (II) oksida u tkivima.
English: Keep this medicine out of the sight and reach of children
Croatian: Kako čuvati INOmax Ovaj lijek čuvajte izvan pogleda i dohvata djece.
English: Abrupt discontinuation of the administration of inhaled nitric oxide may cause rebound reaction; decrease in oxygenation and increase in central pressure and subsequent decrease in systemic blood pressure.
Croatian: Nagli prekid primjene inhalacije dušikovog (II) oksida može uzrokovati povratnu reakciju; smanjenje oksigenacije i povećanje središnjeg tlaka te posljedično smanjenje sistemskog krvnog tlaka.
English: Infants who cannot be weaned off INOmax by 4 days should undergo careful diagnostic work-up for other diseases.
Croatian: Kod novorođenčadi koja se ne mogu odviknuti od INOmax-a nakon 4 dana liječenja potrebna je dodatna dijagnostička obrada radi isključivanja drugih bolesti.
English: It, therefore, is recommended that prior to the administration of nitric oxide, pulmonary artery catheterisation or echocardiographic examination of central haemodynamics be performed.
Croatian: Stoga se preporučuje da se prije davanja dušikovog (II) oksida učini kateterizacija plućne arterije ili ehokardiografija radi procjene hemodinamike.
English: Your doctor will decide the correct dose of INOmax and will administer INOmax to you or your child's lungs through a system designed for delivering this gas.
Croatian: Vaš liječnik će odrediti točnu dozu INOmax-a i primijeniti ga pomoću sustava namijenjenog dopremi tog plina u Vaša pluća ili pluća Vašeg djeteta.
English: The monitoring of NO2 formation
Croatian: • praćenju stvaranja NO2
English: This gas mixture can improve heart function and increase the flow of blood through the lungs, which may help to increase the amount of oxygen that reaches the blood.
Croatian: Ova smjesa plinova može poboljšati rad srca i povećati protok krvi kroz pluća i tako povećati količinu kisika koja dospijeva u krv.
English: When inhaled, nitric oxide produces selective pulmonary vasodilation.
Croatian: Prilikom inhalacije dušikov (II) oksid uzrokuje selektivnu pulmonalnu vazodilataciju.
English: Inhaled nitric oxide has been shown to selectively reduce pulmonary vascular resistance and reduce the increased pulmonary artery pressure.
Croatian: Pokazalo se da inhalacija dušikovog (II) oksida selektivno smanjuje plućni vaskularni otpor i povećani plućni arterijski tlak.
English: In clinical trials INOmax has been given in addition to other standard treatment regimes in the peri-operative setting, including inotropic and vasoactive medicinal products.
Croatian: U kliničkim ispitivanjima,tijekom perioperativnog razdoblja INOmax je primjenjivan uz druge standardne lijekove uključujući inotropne i vazoaktivne lijekove.
English: Neonates known to be dependent on right-to-left, or significant left-to-right, shunting of blood.
Croatian: Novorođenčad s desno-lijevom shuntom ili značajnim lijevo-desnim shuntom.
English: Animal models have shown that nitric oxide may interact with haemostasis, resulting in an increased bleeding time.
Croatian: Na životinjskim modelima pokazano je da dušikov (II) oksid djeluje na hemostazu, što može produžiti trajanje krvarenja.
English: Substances known to cause increased methaemoglobin levels should thus be used with caution during therapy with inhaled nitric oxide.
Croatian: Tvari za koje je poznato da uzrokuju povećanje razine methemoglobina stoga treba primjenjivati uz oprez tijekom terapije inhalacije dušikovog (II) oksida.
English: The starting dose of inhaled nitric oxide is 20 ppm (part per million) of inhaled gas.
Croatian: Odrasli Početna doza za inhalaciju dušikovog (II) oksida iznosi 20 ppm (dijelova na milijun) udahnutog plina.
English: prof. Michała Życzkowskiego 17
Croatian: ul. prof. Michała Życzkowskiego 1731-864
English: All regulations concerning handling of pressurised gas cylinders must be followed.
Croatian: Moraju se poštovati svi propisi u vezi s rukovanjem spremnikom za plin pod tlakom.
English: Bradycardia (low cardiac frequency) or too low amount of oxygen in the blood (oxygen desaturation/hypoxemia) due to sudden withdrawal of the treatment, Headache, dizziness, dry throat or shortness of breath following accidental ambient air exposure to nitric oxide (e.g. leakage from equipment or cylinder).
Croatian: bradikardija (usporena brzina rada srca) ili premala količina kisika u krvi (desaturacija kisika/hipoksemija) zbog naglog prekida liječenja, glavobolja, omaglica, suhoća grla ili nedostatak zraka zbog slučajnog izlaganja dušikovom (II)
English: A clinically significant interaction with other medicinal products used in the treatment of hypoxic respiratory failure cannot be excluded based on the available data.
Croatian: Na temelju dostupnih podataka ne mogu se isključiti klinički značajne interakcije s drugim lijekovima koji se primjenjuju u liječenju hipoksične respiratorne insuficijencije.
English: If it is > 2.5 %, the INOmax dose should be decreased and the administration of reducing medicinal products such as methylene blue may be considered.
Croatian: Ako je vrijednost methemoglobina > 2,5%, doza INOmax-a mora se smanjiti, a može se razmotriti primjena redukcijskih sredstava poput metilenskog modrila.
English: The efficacy of INOmax has been investigated in term and near-term newborns with hypoxic respiratory failure resulting from a variety of aetiologies.
Croatian: Djelotvornost INOmax-a ispitana je u donošene novorođenčadi i kasne nedonoščadi s hipoksičnom respiratornom insuficijencijom različite etiologije.
English: The educational material should include information on the following key elements: The risk of rebound effect and the precautions to take when discontinuing the treatment The risk of abrupt discontinuation of INOmax therapy in the event of critical failure of the delivery system and how to prevent it
Croatian: Edukacijski materijal trebao bi sadržavati informacije o sljedećim osnovnim elementima: • opasnosti od povratnog učinka i mjerama opreza koje treba poduzeti pri prekidu liječenja
English: Tel. +385 47 609 200 tg.info@hr.linde-gas.com
Croatian: +385 47 609 200 tg.info@hr.linde-gas.com
English: In patients undergoing heart surgery, an increase in pulmonary artery pressure due to pulmonary vasoconstriction is frequently seen.
Croatian: U bolesnika koji su podvrgnuti operaciji srca zabilježeno je učestalo povećanje plućnog arterijskog tlaka zbog pulmonalne vazokonstrikcije.
English: Do not discard used gas cylinders.
Croatian: Nemojte bacati iskorištene spremnike za plin.
English: Neonates with less than a full response at 20 ppm were evaluated for a response to 80 ppm nitric oxide or control gas.
Croatian: Novoređenčad koja nije postigla potpuni terapijski odgovor na dozu od 20 ppm procijenjena je ponovno pri dozi od 80 ppm ili u odnosu na kontrolni plin.
English: During treatment with nitric oxide, the NO2 concentration should be < 0.5 ppm in the nitric oxide dose range < 20 ppm.
Croatian: Tijekom liječenja dušikovim (II) oksidom, koncentracija NO2 mora biti < 0,5 ppm u rasponu doze dušikovog (II) oksida <20 ppm.
English: A large portion of nitric oxide for inhalation is absorbed systemically.
Croatian: Velik dio inhaliranog dušikovog (II) oksida se apsorbira sistemski.
English: This will be monitored by blood samples and if required the INOmax dose will be decreased and the administration of medicines such as vitamin C, methylene blue, or eventually blood transfusion, in order to improve the oxygen carrying capacity, may be considered.
Croatian: Možda će trebati razmotriti primjenu lijekova poput vitamina C, metilenskog modrila ili, u krajnjem slučaju, transfuzija krvi, kako bi se poboljšao kapacitet prenošenja kisika.
English: In addition, nitric oxide has affinity to metalloproteins and may also react with SH-groups in protein forming nitrosyl compounds.
Croatian: Osim toga, dušikov (II) oksid ima afinitet prema metaloproteinima te može reagirati s SH-skupinama u spojevima nitrozila koji stvaraju proteine.
English: INOmax cylinders should be stored secured in order to avoid falling and thus potentially causing harm.
Croatian: Spremnici INOmax-a moraju se čuvati na sigurnom mjestu kako ne bi pali i prouzročili štetu.
English: There is an increased risk of methaemoglobin formation if substances with a known tendency to increase methaemoglobin concentrations are administered concomitantly with nitric oxide (e.g. alkyl nitrates and sulphonamides).
Croatian: Postoji povećana opasnost od stvaranja methemoglobina u slučaju istovremene primjene tvari s poznatom tendencijom povećavanja koncentracija methemoglobina i dušikovog (II) oksida (npr. alkil nitrati i sulfonamidi).
English: INOmax should not be used in preterm baby < 34 weeks of gestational age.
Croatian: INOmax se ne smije primjenjivati kod nedonoščadi rođene prije 34. tjedna trudnoće.
English: Inhaled nitric oxide therapy should be maintained at 5 ppm until there is improvement in the neonate's oxygenation such that the FiO2 (fraction of inspired oxygen) < 0.60.
Croatian: Terapija inhalacije dušikovog (II) oksida mora se održavati na razini od 5 ppm dok ne dođe do poboljšanja oksigenacije novorođenčeta tako da FiO2 (frakcija udahnutog kisika) bude < 0,60.
English: Av. Infante D. Henrique Lotes 21-24 P-1800-217 Lisboa Tel: + 351 218 310 420 linde.portugal@pt.linde-gas.com
Croatian: Henrique Lotes 21-24 P-1800-217 Lisboa Tel: + 351 218 310 420 linde.portugal@pt.linde-gas.com
English: Nitric oxide is delivered to the patient via mechanical ventilation after dilution with an oxygen/air mixture using an approved (CE-marked) nitric oxide delivery system.
Croatian: Dušikov (II) oksid isporučuje se bolesniku pomoću mehaničke ventilacije nakon razrjeđivanja mješavinom kisika/zraka putem odobrenog sustava (s CE oznakom) za dopremu dušikovog (II)
English: In the presence of oxygen, nitric oxide is rapidly oxidised to derivatives which are toxic to the bronchial epithelium and alveolo-capillary membrane.
Croatian: U prisutnosti kisika, dušikov (II) oksid brzo se oksidira u derivate koji su toksični za bronhijalni epitel i alveolokapilarnu membranu.
English: In cases of failure to respond to inhaled nitric oxide, see section 4.4.
Croatian: Ukoliko ne dođe do pozitivnog odgovora na inhaliranje dušikovog (II) oksida vidjeti dio 4.4.
English: Monitoring formation of methaemoglobin (MetHb) Neonates and infants are known to have diminished MetHb reductase activity compared to adults.
Croatian: Praćenje koncentracije methemoglobina (MetHb) Neonatusi i dojenčad imaju smanjenu aktivnosti
English: +47 23177200 healthcare@no.aga.com
Croatian: Tlf. +47 23177200 healthcare@no.aga.com
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Linde Healthcare AB
Croatian: 11. NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Linde Healthcare AB
English: In the CINRGI trial, 186 term- and near-term neonates with hypoxic respiratory failure and without lung hypoplasia were randomised to receive either INOmax (n=97) or nitrogen gas (placebo; n=89) with an initial dose of 20 ppm weaning to 5 ppm in 4 to 24 hours with median duration of exposure of 44 hours.
Croatian: U ispitivanju CINRGI, 186 donošene novorođenčadi i kasne nedonoščadi s hipoksičnom respiratornom insuficijencijom i bez plućne hipoplazije bilo je randomizirano u skupine koje su primile INOmax (n=97) ili plin dušik (placebo; n=89) u početnoj dozi od 20 ppm uz smanjenje na 5 ppm tijekom 4 do 24 sata s medijanom trajanja izlaganja od 44 sata.
English: The gas cylinders should be transported with appropriate material in order to protect them from risks of shocks and falls.
Croatian: Spremnici s plinom moraju se prevoziti koristeći odgovarajuću opremu koja osigurava njihovu zaštitu od udaraca i padova.
English: No interaction studies have been performed.
Croatian: Nisu provedena ispitivanja interakcija lijeka.
English: What is in this leaflet:
Croatian: Pogledajte dio 4. Što se nalazi u ovoj uputi:
English: Pulmonary hypertension associated with heart surgery Prescription of nitric oxide should be supervised by a physician experienced in cardiothoracic anaesthesia & intensive care.
Croatian: Plućna hipertenzija povezana sa srčanim operacijama Propisivanje dušikovog (II) oksida treba nadzirati liječnik s iskustvom u kardiotorakalnoj anesteziji i intenzivnoj skrbi.
English: Methaemoglobin disposition has been investigated as a function of time and nitric oxide exposure concentration in neonates with respiratory failure.
Croatian: Dispozicija methemoglobina ispitana je kao funkcija vremena i koncentracije nakon izlaganja dušikovom (II) oksidu u novorođenčadi s respiratornom insuficijencijom.
English: Inhaled nitric oxide should be used with caution in patients with complex heart defect, where high pressure in the pulmonary artery is of importance for maintaining circulation.
Croatian: Potreban je oprez kod bolesnika s kompleksnim srčanim greškama kod kojih je povišeni tlak u plućnoj arteriji važan za održavanje cirkulacije.
English: Nitrogen dioxide (NO2) is the main substance formed, and may cause airway inflammation and damage.
Croatian: Glavna tvar koja se stvara je dušikov dioksid (NO2), a može uzrokovati upalu i oštećenje dišnih putova.
English: MM/YYYY
Croatian: MM/GGGG
English: Inhaled nitric oxide should also be used with caution in patients with compromised left ventricular function and elevated baseline pulmonary capillary pressure (PCWP) as they may be at an increased risk of developing cardiac failure (e.g. pulmonary oedema).
Croatian: Inhalaciju dušikovog (II) oksida potrebno je primjenjivati s oprezom u bolesnika s poremećenom funkcijom lijevog ventrikula i povećanim plućnim kapilarnim tlakom (PCWP) jer navedena stanja povećavaju opasnost od zatajenja srca (npr. plućnog edema).
English: This will be monitored by blood samples and if required the dose of inhaled nitric oxide must be reduced.
Croatian: To će se pratiti uzimanjem uzoraka krvi i, ako je potrebno, smanjenjem doze INOmax-a.
English: The rebound may be seen early as well as late during therapy.
Croatian: Povratna reakcija može se pojaviti u početnoj, kao i kasnijim fazama terapije.
English: Inhaled nitric oxide may have a mild but influence on the platelets (components that help the blood to clot) of you or your child and any signs of bleeding and or haematoma should be observed.
Croatian: Inhalacija dušikovog (II) oksida može blago utjecati na trombocite (komponente koje pomažu u zgrušavanju krvi) pa je potrebno pratiti sve eventualne znakove krvarenja ili pojavu modrica (hematoma).
English: INOmax contains nitric oxide, a gas used for the treatment of newborn babies with lung failure associated with high blood pressure in the lungs, a condition known as hypoxic respiratory failure.
Croatian: INOmax sadržava dušikov (II) oksid, plin koji se koristi za liječenje novorođenčadi sa zatajenjem pluća povezanim s visokim krvnim tlakom u plućima.
English: The dose of nitric oxide should be reduced if the concentration of nitrogen dioxide exceeds 0.5 ppm.
Croatian: Doza dušikovog (II) oksida mora se smanjiti ako koncentracija NO2 premaši 0,5 ppm.
English: The doctor will examine you or your child closely for all side effects.
Croatian: Liječnik će vas ili vaše dijete pažljivo pregledati kako bi se utvrdile eventualne nuspojave.
English: The gas cylinders should be stored in an airy, clean and locked place, for storage of medicinal gas only.
Croatian: Spremnici s plinom moraju se čuvati na prozračnom, čistom i zaključanom mjestu predviđenom za čuvanje samo medicinskih plinova.
English: In biological tissue, nitric oxide may form peroxynitrite with superoxide (O2-), an unstable compound which may cause tissue damage through further redox reactions.
Croatian: (II) oksid može stvoriti peroksinitrit sa superoksidom (O2-), nestabilan spoj koji može prouzročiti oštećenje tkiva putem daljnjih redoks reakcija.
English: All regulations concerning handling of pressure vessels must be followed.
Croatian: Moraju se poštovati svi propisi u vezi s rukovanjem spremnicima pod tlakom.
English: Operation - Pre-use check list procedure (a series of steps required immediately prior to each patient initiation to ensure that the system is working properly and that the system is purged of NO2) - Setting the device for the correct concentration of nitric oxide to be administered
Croatian: Rukovanje - postupak primjene kontrolnog popisa prije upotrebe (niz postupaka koje je potrebno provesti neposredno prije početka liječenja svakog bolesnika, a kojima se osigurava ispravan rad sustava i pročišćivanje sustava od NO2) - podešavanje ispravne koncentracije dušikovog (II) oksida koji se treba primijeniti - podešavanje gornjih i donjih vrijednosti alarma za NO, NO2 i O2
English: How to use INOmax
Croatian: Kako primjenjivati INOmax
English: It relaxes vascular smooth muscle by binding to the haeme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation.
Croatian: Vezivanjem na hem skupinu citosolne gvanilat ciklaze, aktiviranjem gvanilat ciklaze i povećavanjem međustanične razine cikličkog gvanozin 3',5'-monofosfata dovodi do opuštanja glatkih mišića krvnih žila što posljedično dovodi do vazodilatacije.
English: The primary outcome, of the combined efficacy endpoints of death or BPD at 36 weeks GA, was not significantly different between groups, even with adjustment for gestational age as a covariate (p = 0.40), or with birth weight as a covariate (p = 0.41).
Croatian: Primarni ishod, kombinirani rezultati djelotvornosti s obzirom na broj smrtnih slučajeva ili bronhopulmonalnu bolest (BPD) u gestacijskoj dobi od 36 tjedana, nije se značajno razlikovao u obje skupine, čak i uz prilagođavanje gestacijske dobi (p = 0,40) ili težine pri porodu (p =
English: The pharmacokinetics of nitric oxide has been studied in adults.
Croatian: Farmakokinetička svojstva dušikovog (II) oksida ispitana su na odraslim bolesnicima.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 01/08/2001
Croatian: Datum prvog odobrenja: 01.08.2001.
English: No effect of inhaled nitric oxide has been documented in newborn babies with a malformation where the diaphragm is not fully complete, so called ‘congenital diaphragmatic hernia'.
Croatian: Nisu zabilježeni nikakvi učinci inhalacije dušikovog (II) oksida u novorođenčadi s malformacijom kod koje dijafragma (ošit) nije potpuno razvijena, takozvanom prirođenom dijafragmalnom kilom.
English: For you or your child's safety, the delivery systems intended for administration of INOmax are fitted with devices that constantly measure the amount of nitric oxide, oxygen and nitrogen dioxide (a chemical formed when nitric oxide and oxygen are mixed) being delivered to the lungs.
Croatian: Radi Vaše sigurnosti ili sigurnosti Vašeg djeteta, sustavi za dopremu namijenjeni primjeni INOmax-a opremljeni su uređajima koji stalno mjere količinu dušikovog (II) oksida, kisika i dušikovog dioksida
English: The potential risk of bleeding and haemostasis disorders The potential risks if used in combination with other vasodilators which act on cGMP or cAMP
Croatian: • potencijalnim rizicima u slučaju korištenja s drugim vazodilatatorima koji djeluju na cGMP ili cAMP.
English: Too rapid weaning from inhaled nitric oxide therapy carries the risk of a re-bound increase in pulmonary artery pressure with subsequent circulatory instability.
Croatian: U slučaju prebrzog odvikavanja od dušikovog (II) oksida postoji opasnost od ponovnog povećanja plućnog arterijskog tlaka uz posljedičnu hemodinamsku nestabilnost.
English: When inhaled, this gas mixture can improve the flow of blood through the lungs, which may help to increase the amount of oxygen that reaches your baby's blood.
Croatian: Udisanjem ove smjese plinova može se poboljšati protok krvi kroz pluća i tako povećati količinu kisika koja dospijeva u krv novorođenčeta.
English: Gas cylinders are to be stored in wellventilated rooms or in ventilated sheds where they are protected from rain and direct sunlight.
Croatian: Spremnici s plinom moraju se čuvati u prostorijama s dobrom ventilacijom ili u ventiliranim natkrivenim spremištima, gdje će biti zaštićene od kiše i izravne sunčeve svjetlosti.
English: Care must be taken when INOmax is given at the same time as medicinal products containing prilocaine.
Croatian: Potreban je oprez pri istovremenoj primjeni INOmax-a i lijekova koji sadrže prilokain.
English: INOmax should be used only after respiratory support has been optimised.
Croatian: INOmax treba primjenjivati tek nakon optimizacije konzervativne potpore.
English: Intermittent flow neonatal ventilation may be associated with spikes in nitric oxide concentration.
Croatian: Neonatalna ventilacija s intermitentnim protokom može biti povezana sa skokovima u koncentraciji dušikovog (II) oksida.
English: Inside this place, a separate premise should be dedicated to the storage of nitric oxide gas cylinders.
Croatian: U okviru tog prostora potrebno je odvojiti poseban prostor za čuvanje spremnika s dušikovim oksidom.
English: Correct set-up and connections - Connections to the gas cylinder and to the ventilator patient breathing circuit
Croatian: - priključci na spremnik za plin i na respiracijski krug između bolesnika i respiratora
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING 2 litres gas cylinder
Croatian: PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKIRANJU Spremnik s plinom od 2 litre
English: The table below presents adverse reactions (ADRs) that have been reported with the use of INOmax from either the CINRGI trial of 212 neonates or post marketing experience in neonates (<1 months of age)).
Croatian: U tablici u nastavku navedene su nuspojave (ADR) prijavljene prilikom primjene INOmax-a u probnom ispitivanju CINRGI na 212 novorođenčadi ili u novorođenčadi (u dobi od < 1 mjeseca)
English: - If you have any further questions, ask your doctor - If you get any side effects, talk to your doctor.
Croatian: - Ako imate dodatnih pitanja, obratite se svom liječniku.
English: Elevations in methaemoglobinaemia reduce the oxygen delivery capacity of the circulation.
Croatian: povećanje methemoglobina, čime se smanjuje sposobnost prenošenja kisika.
English: See section 4.2 for information on monitoring for NO2.
Croatian: Za više pojedinosti o praćenju NO2 vidjeti dio 4.2.
English: Persistent Pulmonary Hypertension in the Newborn (PPHN) Prescription of nitric oxide should be supervised by a physician experienced in neonatal intensive care.
Croatian: Perzistentna plućna hipertenzija novorođenčeta (PPHN) Propisivanje dušikovog (II) oksida treba nadzirati liječnik s iskustvom u intenzivnoj skrbi novorođenčadi.
English: Weaning from inhaled nitric oxide should be performed with caution.
Croatian: Odvikavanje od inhalacija dušikovog (II) oksida potrebno je provesti uz oprez.
English: If the submission of a PSUR and the update of a RMP coincide, they can be submitted at the same time
Croatian: Plana (RMP), dokumenti mogu biti podneseni istodobno.