FrancophonIA/ELRC3.0 huggingface dataset:
English: You may need to have blood checks if you take: - potassium supplements - salt substitutes containing potassium - potassium sparing medicines or other diuretics (water tablets) - some laxatives - medicines for the treatment of gout - therapeutic vitamin D supplements - medicines to control heart rhythm - medicines for diabetes (oral agents or insulins) - carbamazepine (a medicine for the treatment of epilepsy).
Slovenian: Morda bodo potrebne krvne preiskave, če jemljete: - pripravke s kalijem; - nadomestke soli, ki vsebujejo kalij; - zdravila, ki varčujejo s kalijem ali druge diuretike (tablete za odvajanje vode); - nekatera odvajala; - zdravila za zdravljenje protina; - nadomestke vitamina D; - zdravila za uravnavanje srčnega ritma; - zdravila za zdravljenje sladkorne bolezni (peroralna zdravila ali inzulin); - karbamazepin (zdravilo za zdravljenje epilepsije).
English: Not known: depression, sleep disturbances Non-melanoma skin cancer: Based on available data from epidemiological studies, cumulative dosedependent association between HCTZ and NMSC has been observed (see also sections 4.4 and
Slovenian: Neznana pogostnost: depresija, motnje spanja Nemelanomski kožni rak: Na podlagi obstoječih podatkov epidemioloških študij so ugotovili, da obstaja razmerje med kumulativnim odmerkom hidroklorotiazida in nemelanomskim kožnim rakom (glejte tudi poglavji 4.4 in 5.1).
English: When Ifirmacombi is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid serum levels is recommended.
Slovenian: Če se zdravilo Ifirmacombi uporablja pri bolnikih z okvarjenim ledvičnim delovanjem, je priporočena redna kontrola serumske koncentracije kalija, kreatinina in sečne kisline.
English: The effects of CYP2C9 inducers such as rifampicin on the pharmacokinetic of irbesartan have not been evaluated.
Slovenian: Vpliva induktorjev CYP2C9, kot je rifampicin, na farmakokinetiko irbesartana niso proučevali.
English: Limited clinical data (7 out of 22 patients) suggest that patients not controlled with the 300 mg/12.5 mg combination may respond when uptitrated to 300 mg/25 mg.
Slovenian: Omejeni klinični podatki (7 od 22 bolnikov) kažejo, da se lahko bolniki, pri katerih krvni tlak ni urejen s kombinacijo 300 mg/12,5 mg, odzovejo na povečanje odmerka na 300 mg/25 mg.
English: When angiotensin II antagonists are administered simultaneously with non-steroidal antiinflammatory drugs (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Slovenian: Pri sočasnem zdravljenju z antagonisti angiotenzina II in nesteroidnimi protivnetnimi zdravili (NSAID) (npr. s selektivnimi zaviralci COX-2, acetilsalicilno kislino /> 3 g/dan/ in neselektivnimi NSAID) se antihipertenzivni učinek lahko zmanjša.
English: Not known: respiratory distress (including pneumonitis and pulmonary oedema)
Slovenian: Neznana pogostnost: respiratorni distres (vključno s pljučnico in pljučnim edemom)
English: Among 898 hypertensive patients who received various doses of irbesartan/hydrochlorothiazide (range: 37.5 mg/6.25 mg to 300 mg/25 mg) in placebo-controlled trials, 29.5% of the patients experienced adverse reactions.
Slovenian: Med 898 bolniki s hipertenzijo, ki so v s placebom nadzorovanih študijah prejemali različne odmerke kombinacije irbesartana in hidroklorotiazida (razpon: od 37,5 mg/6,25 mg do 300 mg/25 mg), je imelo 29,5 % bolnikov neželene učinke.
English: Pressor amines (e.g. noradrenaline): the effect of pressor amines may be decreased, but not sufficiently to preclude their use;
Slovenian: Presorni amini (npr. noradrenalin): Njihova učinkovitost se lahko zmanjša, vendar ne za toliko, da bi bilo treba zdravljenje prekiniti.
English: Sulfonamide drugs or sulfonamide derivative drugs can cause an idiosyncratic reaction, resulting in transient myopia and acute angle-closure glaucoma.
Slovenian: Zdravila, ki vsebujejo sulfonamide ali njihove derivate lahko povzročijo idiosinkratično reakcijo s posledično prehodno kratkovidnostjo in akutnim glavkomom z zaprtim zakotjem.
English: C irbesartan, about 20% of the radioactivity is recovered in the urine, and the remainder in the faeces.
Slovenian: C se s sečem izloči približno 20 % radioaktivne snovi, preostanek pa z blatom.
English: Not known: tinnitus
Slovenian: Neznana pogostnost: tinitus
English: The selective antagonism of the angiotensin-II (AT1) receptors results in increases in plasma renin levels and angiotensin-II levels, and a decrease in plasma aldosterone concentration.
Slovenian: Zaradi selektivnega antagonizma receptorjev angiotenzina II (AT1) se povečata plazemski koncentraciji renina in angiotenzina II in zmanjša plazemska koncentracija aldosterona.
English: Children should not take Ifirmacombi
Slovenian: Otroci ne smejo jemati zdravila Ifirmacombi
English: If calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) must be prescribed, serum calcium levels should be monitored and calcium dosage adjusted accordingly;
Slovenian: Kadar bolnik dobiva pripravke s kalcijem ali zdravila, ki varčujejo s kalcijem (npr. vitamin D), je treba preverjati njegovo serumsko koncentracijo in odmerek kalcija po potrebi prilagoditi.
English: dizziness orthostatic dizziness headache
Slovenian: omotica ortostatska omotica glavobol
English: Electrolyte imbalance:
Slovenian: Elektrolitsko neravnovesje
English: Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Slovenian: Otroke, katerih matere so jemale antagoniste angiotenzina II, je treba pozorno spremljati zaradi možnosti pojava hipotenzije (glejte poglavji 4.3 in 4.4).
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started.
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti, in če je primerno, začeti alternativno zdravljenje.
English: There is no difference in response to Ifirmacombi, regardless of age or gender.
Slovenian: Odziv na zdravljenje z zdravilom Ifirmacombi ni odvisen od starosti ali spola.
English: Therefore, the use of Ifirmacombi is not recommended.
Slovenian: Uporaba zdravila Ifirmacombi pri njih zato ni priporočena.
English: Corticosteroids, ACTH: electrolyte depletion, particularly hypokalaemia, may be increased;
Slovenian: Kortikosteroidi, ACTH: Znižanje elektrolitov, še posebej kalija (hipokaliemija).
English: Based on its pharmacodynamic properties, Ifirmacombi is unlikely to affect the ability to drive and use machines.
Slovenian: Na osnovi farmakodinamičnih lastnosti je malo verjetno, da bi zdravilo Ifirmasta HCT vplivalo na sposobnost vožnje in upravljanja s stroji.
English: ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both.
Slovenian: Študija ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) je preučevala koristi dodatka aliskirena standardnemu zdravljenju z zaviralcem ACE ali antagonistom receptorjev angiotenzina II pri bolnikih s sladkorno boleznijo tipa 2 in kronično boleznijo ledvic, kardiovaskularno boleznijo ali obojim.
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti, in če je primerno, začeti drugo ustrezno zdravljenje (glejte poglavji 4.3 in 4.6).
English: Ifirmacombi is not recommended for use in children and adolescents because the safety and efficacy have not been established.
Slovenian: Varnost in učinkovitost zdravila Ifirmacombi nista bili dokazani, zato uporaba pri otrocih in mladostnikih ni priporočljiva.
English: Ifirmacombi is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Slovenian: Zdravila Ifirmacombi ne smete jemati, če ste noseči dlje kot 3 mesece, saj lahko zdravilo v tem obdobju resno škoduje vašemu otroku (glejte poglavje o nosečnosti).
English: The most likely manifestations of irbesartan overdose are expected to be hypotension and tachycardia; bradycardia might also occur.
Slovenian: Po prevelikem odmerjanju irbesartana se najpogosteje pojavita hipotenzija in tahikardija, lahko tudi bradikardija.
English: Serum potassium levels are not significantly affected by irbesartan alone at the recommended doses in patients without risk of electrolyte imbalance (see sections 4.4 and 4.5).
Slovenian: Priporočeni odmerki irbesartana na serumsko koncentracijo kalija bistveno ne vplivajo pri bolnikih, pri katerih ni nevarnosti za pojav motenj elektrolitskega ravnovesja (glejte poglavji 4.4 in 4.5).
English: Thiazides may reduce the renal excretion of cytotoxic medicinal products (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Slovenian: Tiazidi lahko zmanjšajo izločanje citotoksičnih zdravil (npr. ciklofosfamida, metotreksata) skozi ledvice in povečajo njihovo mielosupresivno delovanje.
English: Tables 2 and 3 below detail the adverse reactions reported with the individual components of Ifirmacombi.
Slovenian: V tabelah 2 in 3 so navedeni neželeni učinki, o katerih so poročali pri uporabi posamezne učinkovine zdravila Ifirmacombi.
English: Increase in dosage of probenecid or sulfinpyrazone may be necessary.
Slovenian: Odmerek probenecida ali sulfinpirazona je treba po potrebi povečati.
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypokalaemia, hyponatraemia, and hypochloremic alkalosis).
Slovenian: Tiazidni diuretiki, vključno s hidroklorotiazidom, lahko porušijo tekočinsko ali elektrolitsko ravnovesje (hipokaliemija, hiponatriemija, hipokloremična alkaloza).
English: Following oral administration of Ifirmacombi, the absolute oral bioavailability is 6080% and 50-80% for irbesartan and hydrochlorothiazide, respectively.
Slovenian: Po peroralnem jemanju zdravila Ifirmacombi je biološka uporabnost irbesartana približno 60- do 80-odstotna, hidroklorotiazida pa 50- do 80-odstotna.
English: Table 3: Adverse reactions reported with the use of hydrochlorothiazide alone Investigations
Slovenian: Tabela 3: Neželeni učinki, o katerih so poročali pri uporabi samega hidroklorotiazida Preiskave
English: Preparations containing lithium should not be taken with Ifirmacombi without close supervision by your doctor.
Slovenian: Zdravila, ki vsebujejo litij, smete z zdravilom Ifirmacombi jemati le pod strogim zdravniškim nadzorom.
English: Uncommon syncope, hypotension, tachycardia, oedema
Slovenian: Občasni: sinkopa, hipotenzija, tahikardija, edem
English: Irbesartan does not inhibit ACE (kininase-II), an enzyme which generates angiotensin-II and also degrades bradykinin into inactive metabolites.
Slovenian: Irbesartan ne zavira ACE (kininaza II), encima, ki tvori angiotenzin II in razgrajuje bradikinin v neaktivne presnovke.
English: Hydrochlorothiazide crosses the placental but not the blood-brain barrier, and is excreted in breast milk.
Slovenian: Hidroklorotiazid prehaja skozi placento, ne pa tudi skozi hematoencefalno bariero, in se izloča v materino mleko.
English: - If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take Ifirmacombi” and “Warnings and precautions”)
Slovenian: Zdravnik vam bo morda moral spremeniti odmerek in/ali upoštevati druge previdnostne ukrepe: - Če jemljete zaviralec ACE ali aliskiren (glejte tudi informacije pod naslovoma "Ne jemljite zdravila Ifirmacombi" in "Opozorila in previdnostni ukrepi").
English: The antihypertensive effect of Ifirmacombi may be increased with the concomitant use of other antihypertensive agents.
Slovenian: Antihipertenzivni učinek zdravila Ifirmacombi se lahko med sočasnim jemanjem drugih antihipertenzivov poveča.
English: Side effects associated with hydrochlorothiazide alone Skin and lip cancer (non-melanoma skin cancer); loss of appetite; stomach irritation; stomach cramps; constipation; jaundice (yellowing of the skin and/or whites of the eyes); inflammation of the pancreas characterised by severe upper stomach pain, often with nausea and vomiting; sleep disorders; depression; blurred vision; lack of white blood cells, which can result in frequent infections, fever; decrease in the number of platelets (a blood cell essential for the clotting of the blood), decreased number of red blood cells (anaemia) characterised by tiredness, headaches, being short of breath when exercising, dizziness and looking pale; kidney disease; lung problems including pneumonia or buildup of fluid in the lungs; increased sensitivity of the skin to the sun; inflammation of blood vessels; a skin disease characterized by the peeling of the skin all over the body; cutaneous lupus erythematosus, which is identified by a rash that may appear on the face, neck, and scalp; allergic reactions; weakness and muscle spasm; altered heart rate; reduced blood pressure after a change in body position; swelling of the salivary glands; high sugar levels in the blood; sugar in the urine; increases in some kinds of blood fat; high uric acid levels in the blood, which may cause gout.
Slovenian: Neželeni učinki, ki so povezani z jemanjem hidroklorotiazida samega Kožni rak in rak ustnice (nemelanomski kožni rak); izguba apetita; draženje želodca; želodčni krči; zaprtost; zlatenica (rumeno obarvanje kože in/ali očesnih beločnic); vnetje trebušne slinavke, za katerega je značilna huda bolečina v zgornjem predelu trebuha, ki jo pogosto spremljata slabost in bruhanje; motnje spanja; depresija; zamegljen vid; zmanjšanje števila belih krvnih celic, kar ima lahko za posledico pogostejše okužbe in zvišano telesno temperaturo; zmanjšanje števila trombocitov (krvnih celic, pomembnih za strjevanje krvi), zmanjšanje števila rdečih krvnih celic (anemija), kar spremljajo značilna utrujenost, glavobol, zasoplost pri telesni dejavnosti, omotica in bledica; ledvična bolezen; pljučna bolezen, vključno s pljučnico in kopičenjem tekočine v pljučih; večja občutljivost kože za sončno svetlobo; vnetje krvnih žil; kožna bolezen, za katero je značilno luščenje kože po celem telesu; kožni eritematozni lupus, ki se kaže z izpuščajem po obrazu, vratu in lasišču; alergijske reakcije; oslabelost in mišični krči; spremembe srčnega utripa; znižanje krvnega tlaka po spremembi telesnega položaja; otekanje žlez slinavk; zvišanje vrednosti sladkorja v krvi; sladkor v urinu; zvišanje vrednosti nekaterih maščob v krvi; zvišanje vrednosti sečne kisline v krvi, kar lahko povzroči protin.
English: Forty-seven percent (47.2%) of patients on the combination achieved trough SeDBP < 90 mmHg compared to 33.2% of patients on irbesartan (p = 0.0005).
Slovenian: SeDBP < 90 mm Hg na koncu odmernega intervala je bil dosežen pri 47,2 % bolnikov, ki so se zdravili s kombinacijo, in 33,2 % bolnikov, ki so se zdravili z irbesartanom (p = 0,0005).
English: The effect of the combination of irbesartan and hydrochlorothiazide on morbidity and mortality has not been studied.
Slovenian: Vpliva kombiniranega zdravljenja z irbesartanom in hidroklorotiazidom na obolevnost in smrtnost niso proučevali.
English: This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially "sodiumfree".
Slovenian: Natrij: To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni "brez natrija".
English: There is no experience regarding the administration of Ifirmacombi in patients with recent kidney transplantation.
Slovenian: Izkušenj z uporabo zdravila Ifirmacombi pri bolnikih po nedavni presaditvi ledvice ni.
English: Diuretic agents such as the hydrochlorothiazide contained in Ifirmacombi may have an effect on other medicines.
Slovenian: Diuretiki, med katere spada tudi hidroklorotiazid, ki ga vsebuje zdravilo Ifirmacombi, lahko vplivajo na delovanje drugih zdravil.
English: However, this effect of hydrochlorothiazide on serum potassium would be expected to be potentiated by other medicinal products associated with potassium loss and hypokalaemia (e.g. other kaliuretic diuretics, laxatives, amphotericin, carbenoxolone, penicillin G sodium).
Slovenian: Kljub temu lahko pričakujemo, da se bo učinek hidroklorotiazida na izgubo kalija povečal pri sočasnem jemanju drugih zdravil, ki so povezana s povečano izgubo kalija in hipokaliemijo (npr. pri uporabi drugih kaliuretičnih diuretikov, odvajal, amfotericina, karbenoksolona, natrijeve soli penicilina G).
English: Not known: jaundice (intrahepatic cholestatic jaundice)
Slovenian: Neznana pogostnost: zlatenica (intrahepatska holestatska zlatenica)
English: Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloremia, hyponatraemia) and dehydration resulting from excessive diuresis.
Slovenian: Po prevelikem odmerjanju hidroklorotiazida se pojavita izguba elektrolitov (hipokaliemija, hipokloremija, hiponatriemija) in dehidracija, ki sta posledici čezmerne diureze.
English: Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnaesemia.
Slovenian: Tiazidi povečajo izločanje magnezija s sečem, zato se lahko pojavi hipomagneziemija.
English: When irbesartan is administered concomitantly with a low dose of hydrochlorothiazide (e.g. 12.5 mg daily), the antihypertensive response in black patients approaches that of non-black patients.
Slovenian: Če se irbesartanu doda majhen odmerek hidroklorotiazida (npr. 12,5 mg na dan), se antihipertenzivni učinek pri temnopoltih bolnikih približa učinku pri netemnopoltih bolnikih.
English: Not known Non-melanoma skin cancer (Basal cell carcinoma and Squamous cell carcinoma)
Slovenian: Neznana pogostnost: nemelanomski kožni rak (bazalnocelični karcinom in ploščatocelični karcinom)
English: In patients whose vascular tone and renal function depend predominantly on the activity of the reninangiotensin-aldosterone system (e.g. patients with severe congestive heart failure or underlying renal disease, including renal artery stenosis), treatment with angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists that affect this system has been associated with acute hypotension, azotaemia, oliguria, or rarely acute renal failure (see section 4.5).
Slovenian: Pri bolnikih, pri katerih sta žilni tonus in ledvično delovanje odvisna predvsem od delovanja reninskoangiotenzinsko-aldosteronskega sistema (npr. pri bolnikih s hudim kongestivnim srčnim popuščanjem ali ledvično boleznijo, vključno s stenozo ledvične arterije), se lahko med zdravljenjem z zaviralci angiotenzinske konvertaze ali antagonisti angiotenzina II, ki vplivajo na ta sistem, pojavijo akutna hipotenzija, azotemija, oligurija in redko akutna ledvična odpoved (glejte poglavje 4.5).
English: Ifirmacombi is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Slovenian: Zdravila Ifirmacombi ne smete jemati, če ste noseči dlje kot 3 mesece, saj lahko zdravilo po tretjem mesecu nosečnosti resno škoduje vašemu otroku.
English: Thiazides may decrease urinary calcium excretion and cause an intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism.
Slovenian: Tiazidi lahko zmanjšajo izločanje kalcija s sečem ter povzročijo občasno in blago povečanje njegove serumske vrednosti v odsotnosti motenj presnove kalcija.
English: Warning signs of fluid or electrolyte imbalance are dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea or vomiting.
Slovenian: Opozorilni znaki porušenega ravnovesja so suha usta, žeja, slabost, letargija, omotičnost, nemirnost, bolečine ali krči v mišicah, mišična utrujenost, hipotenzija, oligurija, tahikardija in prebavne motnje, kot sta navzea in bruhanje.
English: As with ACE inhibitors, concomitant use of angiotensin II antagonists and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Slovenian: Tako kot zdravljenje z zaviralci ACE tudi sočasno jemanje antagonistov angiotenzina II in NSAID lahko poveča tveganje za poslabšanje ledvičnega delovanja, vključno z možno akutno ledvično odpovedjo, in povečanje kalija v plazmi, še posebej pri bolnikih, pri katerih je že ugotovljeno slabše ledvično delovanje.
English: The blood pressure lowering effect of irbesartan in combination with hydrochlorothiazide is apparent after the first dose and substantially present within 1-2 weeks, with the maximal effect occurring by 68 weeks.
Slovenian: Krvni tlak se zniža že po prvem odmerku irbesartana in hidroklorotiazida, izrazito v 1 do 2 tednih, najbolj pa v 6 do 8 tednih.
English: swelling extremity arthralgia, myalgia
Slovenian: otekanje udov artralgija, mialgija
English: Hypotension - Volume-depleted patients:
Slovenian: Hipotenzija - zmanjšan intravaskularni volumen
English: Not known: anaphylactic reactions, toxic epidermal necrolysis, necrotizing angitis (vasculitis, cutaneous vasculitis), cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, photosensitivity reactions, rash, urticaria
Slovenian: Neznana pogostnost: anafilaktične reakcije, toksična epidermalna nekroliza, nekrotizirajoči angiitis (vaskulitis, vnetje kožnih žil ali mezgovnic), reakcije, podobne kožnemu eritematoznemu lupusu, reaktivacija kožnega eritematoznega lupusa, fotosenzitivne reakcije, izpuščaj, urtikarija
English: Cases of photosensitivity reactions have been reported with thiazides diuretics (see section 4.8).
Slovenian: Pri uporabi tiazidnih diuretikov so poročali o fotosenzitivnih reakcijah (glejte poglavje 4.8).
English: Due to the hydrochlorothiazide contained in Ifirmacombi, if you drink alcohol while on treatment with this medicine, you may have an increased feeling of dizziness on standing up, specially when getting up from a sitting position.
Slovenian: Če med zdravljenjem z zdravilom Ifirmacombi pijete alkoholne pijače, lahko hidroklorotiazid, ki ga vsebuje zdravilo Ifirmacombi, povzroči omotico v stoječem položaju, še posebej po vstajanju iz sedečega položaja.
English: At very high doses (≥ 500 mg/kg/day) degenerative changes in the kidneys (such as interstitial nephritis, tubular distention, basophilic tubules, increased plasma concentrations of urea and creatinine) were induced by irbesartan in the rat and the macaque and are considered secondary to the hypotensive effects of the medicinal product which led to decreased renal perfusion.
Slovenian: Zelo veliki odmerki irbesartana (≥ 500 mg/kg/dan) so povzročili degeneracijske spremembe ledvic (npr. intersticijski nefritis, razširjanje tubulov, bazofilne tubule, povečano plazemsko koncentracijo sečnine in kreatinina) pri podganah in opicah, kar je bila verjetno posledica hipotenzivnega učinka zdravila, zaradi katerega se je zmanjšala renalna perfuzija.
English: The effects of the irbesartan/hydrochlorothiazide combination on fertility have not been evaluated in animal studies, as there is no evidence of adverse effect on fertility in animals or humans with either irbesartan or hydrochlorothiazide when administered alone.
Slovenian: Vpliva kombinacije irbesartana in hidroklorotiazida na plodnost v študijah na živalih niso ugotavljali, saj neželenih učinkov bodisi irbesartana bodisi hidroklorotiazida na plodnost pri živalih in ljudeh niso dokazali.