FrancophonIA/ELRC3.0 huggingface dataset:
English: If you take more <Invented name> than you should If you have accidentally taken too much <Invented name> see your doctor or contact your nearest hospital emergency department immediately.
Slovenian: Če ste vzeli večji odmerek zdravila <(Lastniško) ime zdravila>, kot bi smeli Če ste po nesreči vzeli preveč zdravila <(Lastniško) ime zdravila>, takoj pojdite k svojemu zdravniku ali v nujno ambulanto najbližje bolnišnice.
English: Small numbers of children were included in various trials; however, there also exists one randomised controlled (vs. cyclosporine micro-emulsion and in combination with corticosteroids and azthioprine) 6-months paediatric study.
Slovenian: Različna preskušanja so zajela manjše število otrok, vendar pa obstaja tudi ena randomizirana, kontrolirana (v primerjavi z mikroemulzijo ciklosporina ter v kombinaciji s kortikosteroidi in aztioprinom) šestmesečna pediatrična študija.
English: In adult and paediatric liver transplant patients, it averaged 11.7 hours and 12.4 hours, respectively, compared with 15.6 hours in adult kidney transplant recipients.
Slovenian: Pri odraslih oz. pediatričnih bolnikih s presajenimi jetri je povprečno 11,7 ure oz. 12,4 ure, pri odraslih prejemnikih presajene ledvice pa 15,6 ure.
English: Decreases in AUC (2 to 12%) and Cmax (15 to 38%), and an increase in tmax (38 to 80%) in whole blood were evident.
Slovenian: Opazni sta bili zmanjšanji AUC (od 2 do 12 %) in Cmax (od 15 do 38 %) ter zvečanje tmax (od 38 do 80 %) v polni krvi.
English: The interim analysis of a recent multicentre study discussed 110 patients who underwent 1:1 randomisation to either tacrolimus or ciclosporin.
Slovenian: Vmesna analiza novejše multicentrične študije obravnava 110 bolnikov, ki so bili v razmerju 1:1 randomizirani na takrolimus ali ciklosporin.
English: In cases of oral intoxication, gastric lavage and/or the use of adsorbents (such as activated charcoal) may be helpful, if used shortly after intake.
Slovenian: Pri peroralni intoksikaciji lahko pomaga izpiranje želodca in/ali uporaba adsorbensov (npr. aktivnega oglja), če je uporabljeno kmalu po zaužitju.
English: Human data demonstrate that tacrolimus is excreted into breast milk.
Slovenian: Podatki pri ljudeh kažejo, da se takrolimus izloča v materinem mleku.
English: In plasma, tacrolimus is highly bound (> 98.8%) to plasma proteins, mainly to serum albumin and α-1-acid glycoprotein.
Slovenian: V plazmi je takrolimus v veliki meri (> 98,8 %) vezano na plazemske beljakovine, predvsem na serumski albumin in α-1-kisli glikoprotein.
English: If clinically relevant changes are seen, adjustments of the immunosuppressive regimen should be considered.
Slovenian: Če se pojavijo klinično pomembne spremembe, je treba razmisliti o prilagoditvi imunosupresivne sheme.
English: inability to urinate, painful menstruation and abnormal menstrual bleeding very rare:
Slovenian: nezmožnost za uriniranje, boleče menstruacije in nenormalne menstruacijske krvavitve zelo redki:
English: - If you have liver problems or have had a disease which may have affected your liver, please tell your doctor as this may affect the dose of <Invented name> that you receive.
Slovenian: - Če imate težave z jetri ali ste kdaj imeli kakšno bolezen, ki bi lahko vplivala na jetra, morate to povedati zdravniku, ker lahko vpliva na vaš odmerek zdravila <(Lastniško) ime zdravila>.
English: You may also be given <Invented name> for an ongoing rejection of your transplanted liver, kidney, heart or other organ or if any previous treatment you were taking was unable to control this immune response after your transplantation.
Slovenian: <(Lastniško) ime zdravila> lahko dobite tudi zaradi dogajajoče se zavrnitve presajenih jeter, srca ali drugega organa, če zdravila, ki ste jih jemali pred tem, niso obvladala imunskega odziva po presaditvi.
English: Acute rejection episodes per 100 patient-days were numerically fewer in the tacrolimus (0.85 episodes) than in the ciclosporin group (1.09 episodes).
Slovenian: Številčno je bilo akutnih zavrnitvenih epizod na 100 bolnik-dni v skupini s takrolimusom manj (0,85 epizode) kot v skupini s ciklosporinom (1,09 epizode).
English: Significantly more ciclosporin-treated patients (n = 13) required a switch to tacrolimus than tacrolimus-treated patients to ciclosporin (n = 2) (p = 0.02) (Keenan et al., Ann Thoracic Surg 1995;60:580).
Slovenian: S ciklosporina na takrolimus je moralo preiti statistično značilno več bolnikov (n = 13) kot s takrolimusa na ciklosporin (n = 2) (p = 0,02) (Keenan et al., Ann Thoracic Surg 1995;60:580).
English: The capsules should be swallowed with fluid (preferably water).
Slovenian: Pogoltniti jih mora s tekočino (najbolje z vodo).
English: Bile flow does not influence the absorption of <Invented name>.
Slovenian: Tok žolča ne vpliva na absorpcijo <(Lastniško) ime zdravila>.
English: For conversion to <Invented name>, treatment should begin with the initial oral dose recommended for primary immunosuppression.
Slovenian: Za prehod na <(Lastniško) ime zdravila> je treba zdravljenje začeti z začetnim peroralnim odmerkom, priporočenim za primarno imunosupresijo.
English: The first dose of oral therapy should be 0.30 mg/kg/day starting 8 to 12 hours after discontinuing intravenous therapy.
Slovenian: Prvi odmerek peroralne terapije mora biti 0,30 mg/kg/dan in mora biti uporabljen od 8 do 12 ur po prekinitvi intravenskega zdravljenja.
English: • Efficacy issues
Slovenian: • Vidiki učinkovitosti
English: In general, dosing may commence orally; if necessary, by administering the capsule contents suspended in water, via nasogastric tubing.
Slovenian: Na splošno se lahko odmerjanje začne peroralno; če je potrebno, je mogoče v vodi suspendirano vsebino kapsule aplicirati po nazogastrični sondi.
English: dermatitis, burning sensation in the sunlight rare:
Slovenian: dermatitis, pekoč občutek na sončni svetlobi redki:
English: In particular, tacrolimus inhibits the formation of cytotoxic lymphocytes, which are mainly responsible for graft rejection.
Slovenian: Takrolimus še posebej zavira nastajanje citotoksičnih limfocitov, ki so predvsem odgovorni za zavrnitev presadkov.
English: <Invented name> belongs to a group of medicines called immunosuppressants.
Slovenian: <(Lastniško) ime zdravila> spada v skupino zdravil, ki jih imenujemo imunosupresivi.
English: increased muscle stiffness very rare:
Slovenian: povečana togost mišic zelo redki:
English: In the early years the initial oral dose of tacrolimus was 0.3 mg/kg/day.
Slovenian: V zgodnjih letih je bil začetni peroralni odmerek takrolimusa 0,3 mg/kg/dan.
English: General considerations
Slovenian: Splošne opombe
English: In the systemic circulation, tacrolimus binds strongly to erythrocytes resulting in an approximate 20:1 distribution ratio of whole blood/plasma concentrations.
Slovenian: V sistemskem obtoku se takrolimus močno veže na eritrocite, zato je porazdelitveno razmerje med koncentracijo v polni krvi in plazmi približno 20:1.
English: Do not use <Invented name> after the expiry date which is stated on the carton after {abbreviation used for expiry date [To be completed nationally]}.
Slovenian: Zdravila <(Lastniško) ime zdravila> ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli poleg oznake {oznaka, ki se uporablja za datum izteka roka uporabnosti [Izpolni država članica]}.
English: Tacrolimus is extensively bound to plasma proteins.
Slovenian: Takrolimus se izdatno veže na beljakovine v plazmi.
English: <Invented name> should be used for intravenous infusion only after it is diluted.
Slovenian: <(Lastniško) ime zdravila> se sme uporabiti za intravensko infundiranje šele po razredčenju.
English: the CHMP has recommended the amendment of the Marketing Authorisations for which the Summary of Product Characteristics, Labelling and Package Leaflet are set out in Annex III of the CHMP Opinion for Prograf and associated names (see Annex I).
Slovenian: je CHMP priporočil dopolnitev dovoljenj za promet z zdravilom, za katera so Povzetek glavnih značilnosti zdravila, Označevanje in Navodilo za uporabo podani v Dodatku III Mnenja CHMP za zdravilo Prograf in z njim povezana imena (glejte Dodatek I).
English: Experience with overdosage is limited.
Slovenian: Izkušenj s prevelikim odmerjanjem je malo.
English: In stable liver transplant patients, the oral bioavailability of <Invented name> was reduced when it was administered after a meal of moderate fat (34% of calories) content.
Slovenian: Pri stabilnih bolnikih s presajenimi jetri se je biološka uporabnost peroralno uporabljenega <(Lastniško) ime zdravila> zmanjšala, če je bil zaužit po obroku z zmerno vsebnostjo maščob (34 % kalorij).
English: Dosage recommendations are provided for rejection therapy, concerning “other allografts”.
Slovenian: Podana so priporočila za odmerjanje pri zdravljenju zavrnitve, ki zadevajo »druge alotransplantate«.
English: A multicentre study included 205 patients undergoing simultaneous pancreas-kidney transplantation who were randomised to tacrolimus (n=103) or to ciclosporin (n=102).
Slovenian: Multicentrična študija je zajela 205 bolnikov, pri katerih je bila hkrati narejena presaditev pankreasa in ledvice; bolnike so randomizirali na takrolimus (n = 103) ali na ciklosporin (n = 102).
English: Capsules should generally be administered on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal, to achieve maximal absorption (see section 5.2).
Slovenian: Da bi dosegli največjo absorpcijo, je kapsule praviloma treba vzeti na prazen želodec ali vsaj 1 uro pred jedjo oz. 2 do 3 ure po jedi (glejte poglavje 5.2).
English: No specific antidote to <Invented name> therapy is available.
Slovenian: Specifičnega antidota za <(Lastniško) ime zdravila> ni.
English: Capsules should be taken immediately following removal from the blister.
Slovenian: Bolnik mora kapsule zaužiti takoj, ko jih vzame iz pretisnega omota.
English: Obliterative bronchiolitis developed in 21.7% of patients in the tacrolimus group compared with 38.0% of patients in the ciclosporin group (p = 0.025).
Slovenian: Obliteracijski bronhiolitis se je pojavil pri 21,7 % bolnikov v skupini s takrolimusom in pri 38,0 % bolnikov v skupini s ciklosporinom (p = 0,025).
English: Do not swallow the desiccant contained in the foil wrapper.
Slovenian: Pazite, da ne zaužijete sušila, ki je v folijskem ovitku.
English: Since levels of tacrolimus in blood may significantly change during diarrhoea episodes, extra monitoring of tacrolimus concentrations is recommended during episodes of diarrhoea.
Slovenian: Ker se lahko koncentracija takrolimusa v krvi med obdobji driske močno spremeni, je med takšnimi obdobji priporočljivo dodatno nadziranje koncentracije takrolimusa.
English: Therefore, in this patient group, EBV-VCA serology should be ascertained before starting treatment with <Invented name>.
Slovenian: Pri takšnih bolnikih je zato treba pred začetkom zdravljenja s <(Lastniško) ime zdravila> opraviti serologijo glede EBV-VCA.
English: The <Invented name> dose may vary depending upon the immunosuppressive regimen chosen.
Slovenian: Odmerek <(Lastniško) ime zdravila> se lahko razlikuje glede na izbrano imunosupresivno shemo.
English: The steady-state volume of distribution based on plasma concentrations is approximately 1300 l (healthy subjects).
Slovenian: Volumen porazdelitve v stanju dinamičnega ravnovesja je glede na koncentracijo v plazmi približno 1.300 litrov (zdravi preiskovanci).
English: The rate and extent of absorption of tacrolimus is greatest under fasted conditions.
Slovenian: Hitrost in stopnja absorpcije takrolimusa sta največji na tešče.
English: problems with blood flow in the liver very rare:
Slovenian: težave s pretokom krvi v jetrih zelo redki:
English: Increased clearance rates contribute to the shorter half-life observed in transplant recipients.
Slovenian: Hitrejši očistek pripomore h krajšemu razpolovnemu času, opaženem pri prejemnikih presadkov.
English: <Invented name> dosing should primarily be based on clinical assessments of rejection and tolerability in each patient individually aided by blood level monitoring (see below for recommended target whole blood trough concentrations).
Slovenian: Odmerjanje <(Lastniško) ime zdravila> mora temeljiti predvsem na klinični oceni zavrnitve in prenašanja pri vsakem bolniku posebej; v dodatno pomoč je spremljanje koncentracije v krvi (za priporočene ciljne najnižje koncentracije v polni krvi glejte v nadaljevanju).
English: Another randomised study included 66 patients on tacrolimus versus 67 patients on ciclosporin.
Slovenian: Druga randomizirana študija je primerjala 66 bolnikov na takrolimusu s 67 bolniki na ciklosporinu.
English: These effects are more frequently observed if <Invented name> is taken in conjunction with alcohol use.
Slovenian: Ti učinki so pogostejši, če je <(Lastniško) ime zdravila> uporabljen hkrati z alkoholom.
English: The risk of anaphylaxis may be reduced by slow infusion of reconstituted <Invented name> 5 mg/ml Concentrate for Solution for Infusion or by the prior administration of an antihistamine.
Slovenian: Tveganje za anafilaksijo je mogoče zmanjšati s počasnim infundiranjem rekonstituiranega <Lastniško ime> 5 mg/1 ml koncentrata za raztopino za infundiranje ali s predhodno uporabo antihistaminika.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Intravenous use.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Intravenska uporaba.
English: As <Invented name> is a medicinal product with low clearance, adjustments to the dosage regimen may take several days before changes in blood levels are apparent.
Slovenian: <(Lastniško) ime zdravila> je zdravilo z majhnim očistkom, zato lahko po prilagoditvi odmerne sheme mine več dni, preden se koncentracija v krvi spremeni.
English: Enhanced nephrotoxicity has been observed following the administration of amphotericin B and ibuprofen in conjunction with tacrolimus.
Slovenian: Večjo nefrotoksičnost so opažali po uporabi amfotericina B in ibuprofena s takrolimusom.
English: <Invented name> therapy should be initiated after considering ciclosporin blood concentrations and the clinical condition of the patient.
Slovenian: Zdravljenje s <(Lastniško) ime zdravila> je treba začeti upoštevaje koncentracijo ciklosporina v krvi in bolnikovo klinično stanje.
English: Pancreas survival at 1 year was significantly superior with tacrolimus: 91.3% versus 74.5% with ciclosporin (p < 0.0005), whereas renal graft survival was similar in both groups.
Slovenian: Preživetje pankreasa je bilo po 1 letu značilno boljše s takrolimusom: 91,3 % v primerjavi s 74,5 % pri ciklosporinu (p < 0,0005); preživetje ledvičnega presadka je bilo v obeh skupinah podobno.
English: In man, the disposition of tacrolimus after intravenous infusion may be described as biphasic.
Slovenian: Dispozicijo takrolimusa po intravenski infuziji pri človeku je mogoče opisati kot dvofazno.
English: Tacrolimus has established itself as an alternative to cyclosporine in cardiac transplant immunosuppression.
Slovenian: Takrolimus se je uveljavil kot alternativa za ciklosporin pri imunosupresivni terapiji po presaditvi srca.
English: Based on its high molecular weight, poor aqueous solubility, and extensive erythrocyte and plasma protein binding, it is anticipated that tacrolimus will not be dialysable.
Slovenian: Glede na veliko molekulsko maso, slabo vodotopnost in izdatno vezavo na eritrocite in beljakovine v plazmi je mogoče pričakovati, da se takrolimus ne bo dializiral.
English: Maintenance doses of corticosteroids have been shown to reduce tacrolimus blood levels.
Slovenian: Dokazano je, da vzdrževalni odmerki kortikosteroidov zmanjšajo koncentracijo takrolimusa v krvi.
English: During the initial post-transplant period, monitoring of the following parameters should be undertaken on a routine basis: blood pressure, ECG, neurological and visual status, fasting blood glucose levels, electrolytes (particularly potassium), liver and renal function tests, haematology parameters, coagulation values, and plasma protein determinations.
Slovenian: V začetnem obdobju po presaditvi je treba rutinsko nadzirati naslednje parametre: krvni tlak, EKG, nevrološko stanje in stanje vida, koncentracijo glukoze na tešče, elektrolite (zlasti kalij), teste delovanja jeter in ledvic, hematološke parametre, koagulacijske vrednosti in koncentracijo beljakovin v plazmi.
English: Caution should be exercised in patients with diagnosed or suspected Congenital Long QT Syndrome.
Slovenian: Previdnost je potrebna pri bolnikih, ki imajo ugotovljen prirojeni sindrom dolgega QT, ali pa obstaja sum, da imajo ta sindrom.
English: Patients switched to <Invented name> therapy should not receive antilymphocyte treatment concomitantly.
Slovenian: Bolniki, ki preidejo na zdravljenje s <(Lastniško) ime zdravila>, sočasno ne smejo dobivati antilimfocitnega zdravljenja.
English: Concomitant use of these substances may require decreased tacrolimus doses in nearly all patients.
Slovenian: Sočasna uporaba teh učinkovin pri skoraj vseh bolnikih zahteva zmanjšanje odmerka takrolimusa.
English: EXPIRY DATE EXP: {MM/YYYY} BATCH NUMBER Batch: {number} CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT [To be completed nationally]
Slovenian: DATUM IZTEKA ROKA UPORABNOSTI ZDRAVILA EXP: {MM/LLLL} ŠTEVILKA SERIJE Serija: {številka} VSEBINA, IZRAŽENA Z MASO, PROSTORNINO ALI ŠTEVILOM ENOT [Izpolni država članica]
English: In rats and rabbits, tacrolimus caused embryofoetal toxicity at doses which demonstrated maternal toxicity (see section 5.3).
Slovenian: Pri podganah in kuncih je takrolimus povzročil embriofetalne toksične učinke v odmerkih, ki so imeli toksične učinke pri samicah-materah (glejte poglavje 5.3).
English: In particular, you should tell your doctor if you are taking or have recently taken medicines with active substances like: - antifungal medicines and antibiotics, particularly so-called macrolide antibiotics, used to treat infections e.g. ketoconazole, fluconazole, itraconazole, voriconazole, clotrimazole,
Slovenian: Še zlasti morate zdravniku povedati, če jemljete ali ste v zadnjem času jemali zdravila, ki vsebujejo zdravilne učinkovine, kot so: - protiglivična zdravila in antibiotiki, zlasti t. i. makrolidni antibiotiki, ki se uporabljajo za zdravljenje okužb, npr. ketokonazol, flukonazol, itrakonazol, vorikonazol, klotrimazol,
English: Clinically the following substances have been shown to decrease tacrolimus blood levels: Strong interactions have been observed with rifampicin, phenytoin or St. John's Wort (Hypericum perforatum) which may require increased tacrolimus doses in almost all patients.
Slovenian: Klinično je ugotovljeno, da koncentracijo takrolimusa v krvi zmanjšujejo naslednje snovi: Močne interakcije so opažali z rifampicinom, fenitoinom ali šentjanževko (Hypericum perforatum), ki zahtevajo večje odmerke takrolimusa pri skoraj vseh bolnikih.
English: After oral administration (0.30 mg/kg/day) to liver transplant patients, steady-state concentrations of <Invented name> were achieved within 3 days in the majority of patients.
Slovenian: Po peroralni uporabi (0,30 mg/kg/dan) pri bolnikih s presajenimi jetri je večina bolnikov dosegla koncentracijo v stanju dinamičnega ravnovesja <(Lastniško) ime zdravila> v 3 dneh.
English: Embryofoetal toxicity was observed in rats and rabbits and was limited to doses that caused significant toxicity in maternal animals.
Slovenian: Embriofetalne toksične učinke so opažali pri podganah in kuncih; omejeni so bili na odmerke, ki so povzročili izrazite toksične učinke pri samicah-materah.
English: Oral administration appears to be associated with a lower incidence of adverse drug reactions compared with intravenous use.
Slovenian: Kaže, da peroralno uporabo spremlja manjša incidenca neželenih reakcij kot intravensko.
English: A strong correlation exists between AUC and whole blood trough levels at steady-state.
Slovenian: Obstaja močna korelacija med AUC in najmanjšo koncentracijo v polni krvi v ravnotežnem stanju.
English: Published clinical experience from a single centre on the use of tacrolimus for primary treatment following intestinal transplantation showed that the actuarial survival rate of 155 patients (65 intestine alone, 75 liver and intestine, and 25 multivisceral) receiving tacrolimus and prednisone was 75% at 1 year, 54% at 5 years, and 42% at 10 years.
Slovenian: Objavljene klinične izkušnje enega samega centra o uporabi takrolimusa pri primarnem zdravljenju po presaditvi črevesa kažejo, da je bilo aktuarsko preživetje 155 bolnikov (65 samo črevo, 75 jetra in črevo, 25 multivisceralno), ki so dobivali takrolimus in prednizon, po 1 letu 75 %, po 5 letih 54 % in po 10 letih 42 %.
English: These dose recommendations for lung, pancreas and intestinal transplantation are based on limited prospective clinical trial data.
Slovenian: Ta priporočila za odmerjanje pri presaditvah pljuč, pankreasa in črevesa temeljijo na omejenih podatkih iz prospektivnih kliničnih preskušanj.
English: erythromycin, clarithromycin, josamycin, and rifampicin - HIV protease inhibitors e.g ritonavir - the anti-ulcer substance omeprazole - hormone treatments with ethinylestradiol (e.g the oral contraceptive pill) or danazol - medicines for high blood pressure or heart problems such as nifedipine, nicardipine, diltiazem and verapamil medicines known as “statins” used to treat elevated cholesterol and triglycerides - the anti-epileptic medicines phenytoin or phenobarbital - the corticosteroids prednisolone and methylprednisolone - the anti-depressant nefazodone - St. John's Wort (hypericum perforatum)
Slovenian: eritromicin, klaritromicin, josamicin in rifampicin - zaviralci proteaz HIV, npr. ritonavir - protiulkusna učinkovina omeprazol - hormonska zdravljenja z etinilestradiolom (npr. kontracepcijske tablete) ali danazol - zdravila za visok krvni tlak ali težave s srcem, npr. nifedipin, nikardipin, diltiazem in verapamil - zdravila, ki jih imenujemo "statini" in se uporabljajo za zdravljenje zvišanega holesterola in trigliceridov - antiepileptično zdravilo fenitoin ali fenobarbital - kortikosteroida prednizolon in metilprednizolon - antidepresiv nefazodon - šentjanževka (Hypericum perforatum)
English: WHAT <INVENTED NAME> IS AND WHAT IT IS USED FOR
Slovenian: KAJ JE ZDRAVILO <(LASTNIŠKO) IME ZDRAVILA> IN ZA KAJ GA UPORABLJAMO
English: Blood trough levels of tacrolimus should also be monitored following dose adjustment, changes in the immunosuppressive regimen, or following co-administration of substances which may alter tacrolimus whole blood concentrations (see section 4.5).
Slovenian: Najmanjšo koncentracijo takrolimusa v krvi je treba nadzirati tudi po prilagoditvi odmerka, spremembah imunosupresijske sheme in po sočasni uporabi snovi, ki lahko spremenijo koncentracijo takrolimusa v polni krvi (glejte poglavje 4.5).
English: Several amendments to the SPC were introduced, in particular pertaining clinical indications (4.1) and the section on posology and method of administration (4.2).
Slovenian: V Povzetek glavnih značilnosti zdravila je bilo vključenih več dopolnitev, zlasti tistih, ki zadevajo klinične indikacije (4.1) ter poglavje o odmerjanju in načinu uporabe (4.2).
English: Concomitant use of medicinal products or herbal remedies known to inhibit or induce CYP3A4 may affect the metabolism of tacrolimus and thereby increase or decrease tacrolimus blood levels.
Slovenian: Sočasna uporaba zdravil ali zeliščnih pripravkov, ki zavirajo ali inducirajo CYP3A4, lahko vpliva na presnovo takrolimusa in poveča ali zmanjša njegovo koncentracijo v krvi.
English: In healthy subjects, the average total body clearance (TBC) estimated from whole blood concentrations was 2.25 l/h.
Slovenian: Pri zdravih preiskovancih je iz koncentracije v polni krvi ocenjeni povprečni celotni telesni očistek (CTO) 2,25 l/uro.
English: Do not take a double dose to make up for forgotten individual doses.
Slovenian: Če ste pozabili vzeti zdravilo <(Lastniško) ime zdravila> Ne vzemite dvojnega odmerka, da bi nadomestili pozabljene odmerke.
English: echocardiogram abnormal
Slovenian: ehokardiografske nepravilnosti
English: thrombotic thrombocytopenic purpura, hypoprothrombinaemia Immune system disorders
Slovenian: trombotična trombocitopenična purpura, hipoprotrombinemija Bolezni imunskega sistema