FrancophonIA/ELRC3.0 huggingface dataset:
English: If you forget to take one dose, take this dose as soon as you remember.
Slovenian: Če ste pozabili vzeti en odmerek, ga vzemite takoj, ko se spomnite.
English: This can result in an increase and/or prolongation of their effects, including adverse reactions.
Slovenian: To lahko poveča in/ali podaljša njihove učinke, vključno z neželenimi učinki.
English: Do not change the prescribed dose yourself.
Slovenian: Predpisanega odmerka ne spreminjajte sami.
English: About 13% of the dose is excreted in the urine, of which 2 to 4% is unchanged medicinal product.
Slovenian: Približno 13 % odmerka se izloči z urinom, od tega je od 2 do 4 % nespremenjenega zdravila.
English: Cmax and AUC increase more than proportionally with dose.
Slovenian: Vrednosti Cmax in AUC se več kot sorazmerno povečata z odmerkom.
English: Close surveillance will be necessary: blood pressure and fluid and electrolyte balance should be monitored for a few days.
Slovenian: Potrebno bo pozorno spremljanje: nekaj dni je treba spremljati krvni tlak ter ravnovesje tekočine in elektrolitov.
English: • Change in laboratory markers
Slovenian: • spremembe laboratorijskih označevalcev,
English: The requirements for submission of PSURsfor this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Slovenian: Zahteve glede predložitve PSUR za to zdravilo so določene v seznamu referenčnih datumov EU (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES, in vseh kasnejših posodobitvah, objavljenih na evropskem spletnem portalu o zdravilih.
English: Careful monitoring of digoxin levels is recommended.
Slovenian: Priporočljivo je skrbno spremljanje ravni digoksina.
English: Aripiprazole dose should be reduced to approximatively one-half of its prescribed dose.
Slovenian: Odmerek aripiprazola je treba zmanjšati na približno polovico predpisanega odmerka.
English: Fatal cases have been reported particularly when treatment is continued despite liver enzyme elevation.
Slovenian: O smrtnih primerih so poročali predvsem, kadar se je zdravljenje nadaljevalo kljub povišanju ravni jetrnih encimov.
English: Treatment of juvenile rats for 30 day beginning at 21 days of age delayed the puberty onset.
Slovenian: Dajanje zdravila juvenilnim podganam, ki je trajalo 30 dni in se je začelo pri 21 dneh starosti, je upočasnilo nastop pubertete.
English: Frequency of hepatotoxicity could be higher in adolescents than in adults.
Slovenian: Pri mladostnikih je lahko pogostnost hepatotoksičnosti večja kot pri odraslih.
English: Serious hepatic toxicity caused by ketoconazole treatment is rare (1/15000).
Slovenian: Resna jetrna toksičnost, ki jo povzroča zdravljenje s ketokonazolom, je redka (1/15.000).
English: Tell your doctor or phamacist if you are taking, have recently taken or might take any other medicines.
Slovenian: Obvestite svojega zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
English: In approximately 10 to 15 % of ketoconazole treated patients, an "escape phenomenon" is observed and reinforces the need for a long-term clinical and biochemical follow-up of these patients.
Slovenian: Pri približno 10 do 15 % bolnikov, zdravljenih s ketokonazolom, so opazili »pojav uhajanja«, kar nadalje podpira potrebo po dolgotrajnem kliničnem in biokemijskem spremljanju teh bolnikov.
English: This medicine is not recommended for children under 12 years due to the lack of data in these patients.
Slovenian: Otroci in mladostniki To zdravilo ni priporočljivo pri otrocih mlajših od 12 let, zaradi nezadostnih podatkov pri teh bolnikih.
English: Monitoring of the QTc interval
Slovenian: Spremljanje intervala QTc
English: Adrenal insufficiency is common and can be a serious side effect.
Slovenian: Adrenalna insuficienca je pogosta in je lahko resen neželeni učinek.
English: Associated with a decrease in corresponding values for the active metabolite
Slovenian: Povezano z zmanjšanjem ustrezajočih vrednosti za aktivni presnovek.
English: Use in Cushing's disease
Slovenian: Uporaba pri Cushingovi bolezni
English: There are no data suggesting a need for a specific dose adjustment in this population.
Slovenian: Podatkov, ki bi kazali na potrebo po posebnem prilagajanju odmerka v tej populaciji, ni.
English: Frequency groupings are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known:
Slovenian: Pogostnost je opredeljena na naslednji način: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10,000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: The adverse reactions listed below in table 2 are classified according to System Organ Class.
Slovenian: Spodaj navedeni neželeni učinki v preglednici 2 so razvrščeni glede na organske sisteme.
English: The maximal dose that was used for treatment of Cushing's syndrome is 1,600 mg/day.
Slovenian: Največji odmerek, ki se je uporabil za zdravljenje Cushingovega sindroma, je bil 1600 mg/dan.
English: Hepatotoxicity does not appear to be dose dependent.
Slovenian: Hepatotoksičnost kot kaže ni odvisna od odmerka.
English: The dose will be adapted to your condition with the aim to restore normal cortisol levels.
Slovenian: Odmerek bo prilagodil vašemu stanju, pri čemer bo cilj ponovna vzpostavitev normalnih ravni kortizola.
English: Bone fragility and broken legs were reported in rats but were not observed in other species.
Slovenian: Pri podganah so poročali o krhkih kosteh in zlomljenih okončinah, vendar tega niso opazili pri drugih živalskih vrstah.
English: Careful monitoring as it may cause an earlier onset and/or an increased severity of side-effects.
Slovenian: Skrbno spremljanje, saj lahko povzroči zgodnji pojav in/ali povečano resnost neželenih učinkov.
English: Centre Spécialités Pharmaceutiques 76-78 avenue du Midi 63800 Courron d‘Auvergne France
Slovenian: Centre Spécialités Pharmaceutiques 76-78 avenue du Midi 63800 Courron d‘Auvergne
English: In vitro, the plasma protein binding is about 99% mainly to the albumin fraction.
Slovenian: Vezava na beljakovine v plazmi in vitro je približno 99-odstotna, predvsem na albuminsko frakcijo.
English: Initiation and follow up of the treatment must be supervised by specialists in endocrinology.
Slovenian: Uvedbo in spremljanje zdravljenja mora nadzorovati specialist endokrinolog.
English: - Prior to the start of ketoconazole - Within one week after the beginning of the treatment - As clinically indicated thereafter.
Slovenian: - pred začetkom uporabe ketokonazola; - v roku enega tedna po začetku zdravljenja; - potem pa kot je klinično indicirano.
English: Plasma elimination is biphasic with a half-life of 2 hours during the first 10 hours and 8 hours thereafter.
Slovenian: Izločanje iz plazme je dvofazno, pri čemer je razpolovni čas v prvih 10 urah 2 uri, potem pa 8 ur.
English: Polfarmex S.A. ul.
Slovenian: Polfarmex S.A.
English: Data on the use of ketoconazole in patients older than 65 years are limited, but there is no evidence to suggest that specific dose adjustment is required in these patients (see section 5.2).
Slovenian: Podatki o uporabi ketokonazola pri bolnikih, starejših od 65 let, so omejeni, vendar ni dokazov, da bi bilo treba pri teh bolnikih odmerek prilagajati (glejte poglavje 5.2).
English: If such a phenomenon occurs, a further dose increase may be required to maintain cortisol levels within the normal range.
Slovenian: Če pride do tega pojava, bo morda potrebno dodatno povečanje odmerka, da se bodo ravni kortizola vzdrževale znotraj normalnih vrednosti.
English: Ketoconazole was stopped, but she deteriorated rapidly and died.
Slovenian: Uporabo ketokonazola so prekinili, vendar se je njeno stanje hitro slabšalo in je umrla.
English: Table 2: Incidence of adverse reactions and marked laboratory abnormalities reported in the literature in adults and adolescents patients
Slovenian: Preglednica 2: Incidenca neželenih učinkov in pomembnih laboratorijskih abnormalnosti, o katerih so pri odraslih in mladostnikih poročali v literaturi
English: Alfentanil, fentanyl
Slovenian: Alfentanil, fentanil
English: The efficacy and safety of ketoconazole in the treatment of Cushing's syndrome from all causes have been described through several published retrospective studies, chart reviews and case reports.
Slovenian: Učinkovitost in varnost ketokonazola pri zdravljenju Cushingovega sindroma zaradi vseh vzrokov so opisali v več objavljenih retrospektivnih študijah, pregledih zdravniških kartotek in poročilih o primerih.
English: The safety and efficacy of Ketoconazole HRA in children aged less than 12 years have not been established.
Slovenian: Varnost in učinkovitost zdravila Ketokonazol HRA pri otrocih, mlajših od 12 let, nista bili dokazani.
English: Studies in animals have shown effects on male and female reproductive parameters (see section 5.3).
Slovenian: Študije na živalih so pokazale učinke na moške in ženske parametre razmnoževanja (glejte poglavje 5.3).
English: Interactions between ketoconazole and other medicinal products are listed in the table below (increase is indicated as “↑”, decrease as “↓”, an no change as “↔”).
Slovenian: Interakcije med ketokonazolom in drugimi zdravili so navedene v spodnji preglednici (povečanje je označeno kot »↑«, zmanjšanje kot »↓«, odsotnost spremembe pa kot »↔«).
English: Liver enzyme levels returned to normal within 2-12 weeks after a dose decrease or withdrawal of ketoconazole.
Slovenian: Ravni jetrnih encimov so se vrnile na normalne v 2 do 12 tednih po zmanjšanju odmerka ali prekinitvi zdravljenja s ketokonazolom.
English: Block and replace regimen
Slovenian: Režim zaviranja in nadomeščanja
English: Inhibition of these different transporters at clinically relevant concentrations of ketoconazole cannot be excluded.
Slovenian: Zaviranje teh različnih prenašalcev v klinično pomembnih koncentracijah ketokonazola ni mogoče izključiti.
English: Improvement of clinical symptoms was noted in most patients after initiation of treatment.
Slovenian: Po uvedbi zdravljenja so izboljšanje kliničnih simptomov opazili pri večini bolnikov.
English: Do not take Ketoconazole HRA if any of the above applies to you.
Slovenian: Ne jemljite zdravila Ketokonazol HRA, če kar koli od zgoraj navedenega velja za vas.
English: Activated charcoal may be given if considered appropriate.
Slovenian: Uporabi se lahko medicinsko oglje, če je primerno.
English: Although hepatotoxicity is usually observed at treatment initiation and within the first six months of treatment, monitoring of liver enzymes should be done under medical criteria.
Slovenian: Čeprav so hepatotoksičnost navadno opazili na začetku zdravljenja in v prvih šestih mesecih zdravljenja, je treba spremljanje jetrnih encimov opravljati skladno z zdravstvenimi merili.
English: Clinical improvement in hypokalaemia, metabolic alkalosis, diabetes mellitus, and hypertension occurred even in the absence of complete hormonal response.
Slovenian: Do kliničnega izboljšanja hipokaliemije, metabolične alkaloze, sladkorne bolezni in hipertenzije je prišlo tudi ob odsotnosti popolnega hormonskega odziva.
English: The major route of excretion is through the bile into the intestinal tract.
Slovenian: Glavna pot izločanja je skozi žolč v črevesje.
English: However, the genotoxic potential was not properly determined for the proposed dosing regimen in the treatment of endogenous Cushing's syndrome.
Slovenian: Vendar genotoksičnega potenciala za predlagan režim odmerjanja pri zdravljenju endogenega Cushingovega sindroma niso ustrezno določili.
English: Sunitinib Dasatinib Lapatinib Nilotinib Erlotinib Dabrafenib Cabozantinib
Slovenian: Dasatinib Lapatinib Nilotinib Erlotinib Dabrafenib Kabozantinib
English: At doses > 400 mg/day, half-lives of 3 to 10 hours have been reported.
Slovenian: Pri odmerkih > 400 mg/dan so poročali o razpolovnem času od 3 do 10 ur.
English: Based on limited data, pharmacokinetics parameters (AUC, Cmax and half-life) of ketoconazole for doses of 5 to 10 mg/kg/days, corresponding approximately to daily doses of 200-800 mg, are similar in paediatric and adult population.
Slovenian: Na podlagi omejenih podatkov so farmakokinetični parametri (AUC, Cmax in razpolovni čas) ketokonazola za odmerke od 5 do 10 mg/kg/dan, kar ustreza približnim dnevnim odmerkom 200-800 mg, podobni pri pediatrični in odrasli populaciji.
English: Potential interaction with medicinal products
Slovenian: Morebitno medsebojno delovanje z zdravili
English: Treatment should be initiated and supervised by physicians experienced in endocrinology or internal medicine and having the appropriate facilities for monitoring of biochemical responses since the dose must be adjusted to meet the patient's therapeutic need, based on the normalisation of cortisol levels.
Slovenian: Zdravljenje morajo uvesti in nadzorovati zdravniki z izkušnjami z endokrinologijo ali interno medicino, ki imajo na voljo ustrezno opremo za spremljanje biokemičnih odzivov, saj je treba odmerek prilagoditi glede na bolnikovo terapevtsko potrebo, ki temelji na normalizaciji ravni kortizola.
English: After ketoconazole withdrawal, liver enzymes returned to normal levels within 3 weeks (section 5.1).
Slovenian: Po prekinitvi ketokonazola so se ravni jetrnih encimov v 3 tednih vrnile na normalne (poglavje 5.1).
English: Use in ectopic Adrenocorticotropic Hormone (ACTH) syndrome
Slovenian: Uporaba pri sindromu ektopične sekrecije adrenokortikotropnega hormona (ACTH)
English: Use of ketoconazole with potent enzyme inducers is not recommended.
Slovenian: Uporaba ketokonazola z močnimi induktorji encimov ni priporočljiva.
English: Ketoconazole has been used both as sole medical therapy and in combination with other medicinal products, mainly with metyrapone, in patients with more severe disease or in those not completely responding to a single active substance or in those requiring a dose reduction of at least one of the medicinal products to improve tolerance.
Slovenian: Ketokonazol se je uporabil kot monoterapija in v kombinaciji z drugimi zdravili, večinoma metiraponom, pri bolnikih s hujšo boleznijo ali bolnikih, ki se niso popolnoma odzivali na eno učinkovino ali ki so potrebovali zmanjšanje odmerka vsaj enega od zdravil zaradi izboljšanja tolerance.
English: Józefów 9, 99-300 Kutno Poland
Slovenian: Józefów 9, 99-300 Kutno
English: Dose reduction of indinavir to 600 mg every 8 hours should be considered.
Slovenian: Skrbno spremljanje.Razmisliti je treba o zmanjšanju odmerka indinavirja na 600 mg vsakih 8 ur.
English: Indinavir (600mg TID): AUC= 0.8-fold
Slovenian: Indinavir (600 mg trikrat na dan): AUC=0,8-krat
English: In the event of accidental overdose, treatment consists of supportive measures.
Slovenian: Zdravljenje nenamernega prevelikega odmerjanja vključuje podporne ukrepe.
English: The safety of ketoconazole has been evaluated based on published literature and use of ketoconazole as an antifungal treatment.
Slovenian: Varnost ketokonazola so ocenili na podlagi objavljene literature in uporabe ketokonazola kot antimikotika.
English: In vitro data indicate that ketoconazole is a potent inhibitor of OATP1B1, OATP1B3, OAT3, OCT1 and OCT2 and to a lesser extent of OAT1 and BSEP.
Slovenian: In vitro podatki kažejo, da je ketokonazol močan zaviralec prenašalcev OATP1B1, OATP1B3, OAT3, OCT1 in OCT2, v manjši meri pa zavira tudi OAT1 in BSEP.
English: Increases in liver enzymes (≤ 5N and > 5N) were observed in ~13.5 % and ~2.5% of patients respectively occurring mostly within the first 6 months of treatment.
Slovenian: Povišanje ravni jetrnih encimov (≤ 5N in > 5N), ki se je večinoma pojavilo v prvih 6 mesecih zdravljenja, so opazili pri ~13,5 % oziroma ~2,5 % bolnikov.
English: The degrees of interaction mentioned below are not absolute values and may be dependent on the ketoconazole dose given, i.e. many results are reported following a ketoconazole dose of 200 mg and a stronger interaction may be expected at a higher dose and/or shorter dosing interval.
Slovenian: Stopnje spodaj navedenih interakcij niso absolutne vrednosti in so lahko odvisne od odmerka ketokonazola, tj. o mnogih rezultatih so poročali po odmerku ketokonazola 200 mg, zato se lahko pri večjem odmerku in/ali krajšem presledku odmerjanja pričakuje močnejša interakcija.
English: HRA Pharma Rare Diseases 200 avenue de Paris 92320 CHATILLON France
Slovenian: 200 avenue de Paris 92320 CHATILLON
English: Considering the rapid absorption of ketoconazole, intake of BCRP substrates should be postponed for 2 hours after ketoconazole intake.
Slovenian: Glede na hitro absorpcijo ketokonazola je treba uporabo substratov BCRP prestaviti na 2 uri po zaužitju ketokonazola.
English: Doses of 80 and 160 mg/kg inhibited ovulation in immature rats.
Slovenian: Odmerka 80 in 160 mg/kg sta zavirala ovulacijo pri neodraslih podganah.
English: Each tablet contains 19 mg of lactose (as monohydrate).
Slovenian: Ena tableta vsebuje 19 mg laktoze (v obliki monohidrata).
English: If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before taking this medicinal product.
Slovenian: Če vam je zdravnik povedal, da nekaterih sladkorjev ne prenašate, se pred jemanjem tega zdravila posvetujte z zdravnikom.
English: Apart from adrenal blocking effect, ketoconazole may also have direct effects on corticotropic tumour cells in patients with Cushing's disease.
Slovenian: Poleg zaviralnega učinka na nadledvične žleze ima lahko ketokonazol neposredne učinke tudi na kortikotropne tumorske celice pri bolnikih s Cushingovo boleznijo.
English: Ketoconazole is widely distributed into tissues; however, only a negligible proportion of ketoconazole reaches the cerebral-spinal fluid.
Slovenian: Ketokonazol se obsežno porazdeli v tkiva, vendar samo zanemarljiv delež ketokonazola doseže cerebrospinalno tekočino.
English: AUC: ↑ 3.0 to 3.9-fold
Slovenian: AUC:↑ 3,0 do 3,9-krat
English: Patients with congenital lactase deficiency, galactosaemia or glucose-galactose intolerance must not be given this medicine unless strictly necessary.
Slovenian: Bolniki z zmanjšano aktivnostjo laktaze, galaktozemijo ali intoleranco za glukozo/galaktozo, ne smejo prejeti tega zdravila, razen če to ni povsem nujno.
English: Monitoring for an effect on the QTc interval is advisable.
Slovenian: Priporočljivo je spremljanje učinka na interval QTc.
English: At treatment initiation, 24-hour urinary free cortisol should be controlled every few days/weeks.
Slovenian: Na začetku zdravljenja je treba vsakih nekaj dni/tednov preverjati 24-urno raven prostega kortizola v urinu.
English: There is no evidence to suggest that there is an interaction between ketoconazole and other steroidogenesis inhibitors (i.e. metyrapone).
Slovenian: Ni dokazov o medsebojnem delovanju ketokonazola in drugih zaviralcev steroidogeneze (tj. metirapona).
English: Use in ACTH-independent Cushing's syndrome
Slovenian: Uporaba pri od ACTH neodvisnem Cushingovem sindromu
English: The recommended initial dose is usually 600 mg per day taken orally (3 tablets per day in 3 divided times).
Slovenian: Priporočeni začetni odmerek je običajno 600 mg na dan peroralno (3 tablete na dan v 3 ločenih delih dneva).
English: At clinically relevant concentrations inhibition of CYP2B6, 2C9/C8, 2C19 and 2D6 by ketoconazole cannot be excluded.
Slovenian: Zaviranja CYP2B6, 2C9/C8, 2C19 in 2D6 zaradi ketokonazola pri klinično pomembnih koncentracijah ni mogoče izključiti.
English: Pharmacotherapeutic group: Antimycotics for systemic use, imidazole derivatives, ATC code: J02AB02
Slovenian: Farmakoterapevtska skupina: antimikotiki za sistemsko zdravljenje, derivati imidazola, oznaka ATC: J02AB02.
English: Not recommended due to an increased bleeding risk.
Slovenian: Ni priporočljivo zaradi povečanega tveganja krvavitve.
English: EU/1/14/965/001
Slovenian: ŠTEVILKA (E) DOVOLJENJA (DOVOLJENJ) ZA PROMET EU/1/14/965/001
English: • Aversion to light
Slovenian: • odpor do svetlobe,
English: Jozefow 9 99-300 Kutno Poland
Slovenian: Jozefow 9 99-300 Kutno
English: Table 1 Interactions and recommendations for co-administration.
Slovenian: Preglednica 1: Medsebojno delovanje in priporočila za sočasno uporabo
English: PVC/Alu blister of 10 tablets Pack sizes containing 60 tablets (6 blisters of 10 tablets).
Slovenian: 6.5 Vrsta ovojnine in vsebina Pretisni omot iz PVC/aluminija z 10 tabletami Pakiranje vsebuje 60 tablet (6 pretisnih omotov s po 10 tabletami).
English: The toxicological profile of ketoconazole has been established from long term studies in rats and dogs.
Slovenian: Toksikološki profil ketokonazola so ugotovili na podlagi dolgotrajnih študij na podganah in psih.
English: The doses used in adolescents above 12 years old were similar to the doses used in adults' patients with endogenous Cushing's syndrome.
Slovenian: Odmerki, ki so jih uporabili pri mladostnikih, starejših od 12 let, so bili podobni kot pri odraslih z endogenim Cushingovim sindromom.
English: It is used to treat endogenous Cushing's syndrome (when the body produces an excess of cortisol) in adults and adolescents above the age of 12 years.
Slovenian: Uporablja se za zdravljenje endogenega Cushingovega sindroma (ko telo proizvaja preveč kortizola) pri odraslih in mladostnikih, starejših od 12 let.
English: Ketoconazole has a high potential for clinically important medicinal products interactions.
Slovenian: Ketokonazol ima velik potencial za klinično pomembne interakcije med zdravili.
English: Due to the risk of serious hepatic toxicity, close follow-up of patients is required (see section 4.2).
Slovenian: Zaradi tveganja resne jetrne toksičnosti je potrebno pozorno spremljanje bolnikov (glejte poglavje 4.2).
English: However in patients with adrenal cortical carcinoma, improvement of hypercortisolism on ketoconazole was limited in some cases.
Slovenian: Pri bolnikih z adrenokortikalnim karcinomom, zdravljenih s ketokonazolom, pa je bilo izboljšanje hiperkortizolizma v nekaterih primerih omejeno.
English: No formal evaluation of the effect of age on the pharmacokinetics of ketoconazole has been performed.
Slovenian: Opravili niso nobene uradne ocene učinka starosti na farmakokinetiko ketokonazola.
English: Lipid Lowering Drugs Lovastatin, simvastatin, atorvastatin*
Slovenian: Lovastatin, simvastatin, atorvastatin*
English: Adrenal insufficiency may be detected by periodic clinical assessment and monitoring of plasma/serum or salivary cortisol levels.
Slovenian: Adrenalno insuficienco je mogoče ugotoviti z rednimi kliničnimi ocenami in spremljanjem ravni kortizola v plazmi/serumu ali slini.
English: In case of co-administration of an medicinal product known to increase QTc interval (see section 4.5), ECG monitoring is recommended.
Slovenian: Če se sočasno uporablja zdravilo, za katerega je znano, da podaljša interval QTc (glejte poglavje 4.5), je priporočeno spremljanje EKG.
English: Other statins that are not CYP3A4 substrates (pravastatin and fluvastatin) can be co-administered with ketoconazole.
Slovenian: Drugi statini, ki niso substrati CYP3A4 (pravastatin in fluvastatin), se lahko uporabljajo sočasno s ketokonazolom.
English: Use with hepatotoxic medicinal products
Slovenian: Uporaba hepatotoksičnih zdravil
English: - Ketoconazole can inhibit the transport of medicinal products by P-gp, which may result in an increased plasma concentration of these medicinal products.
Slovenian: - Ketokonazol lahko zavira transport zdravil prek P-gp, kar lahko poveča koncentracijo teh zdravil v plazmi.
English: Urinary free cortisol (UFC) levels were normalised in about 50% of patients on ketoconazole.
Slovenian: Ravni prostega kortizola v urinu so se normalizirale pri približno 50 % bolnikov, zdravljenih s ketokonazolom.
English: Escape phenomenon
Slovenian: Pojav uhajanja