FrancophonIA/ELRC3.0 huggingface dataset:
English: The average absolute bioavailability of adalimumab estimated from three studies following a single 40 mg subcutaneous dose was 64 %.
Croatian: Prosječna apsolutna bioraspoloživost adalimumaba procijenjena nakon primjene jednokratne supkutane doze od 40 mg bila je 64% u tri ispitivanja.
English: Across all indications in clinical trials patients with raised ALT were asymptomatic and in most cases elevations were transient and resolved on continued treatment.
Croatian: U kliničkim ispitivanjima kod svih indikacija, bolesnici s povišenim razinama ALT-a nisu imali simptome i u većini slučajeva povišenje je bilo prolazno i riješilo se nastavkom liječenja.
English: Patients participating in all Phase 2 and Phase 3 psoriasis studies were eligible to enrol into an openlabel extension trial, where adalimumab was given for at least an additional 108 weeks.
Croatian: Bolesnici koji su sudjelovali u svim ispitivanjima faze II i III kod psorijaze ispunili su kriterije za uključivanje u otvoreni produžetak ispitivanja, gdje se adalimumab primjenjivao još najmanje dodatnih 108 tjedana.
English: Similar antibody responses to the standard 23-valent pneumococcal vaccine and the influenza trivalent virus vaccination were observed in a study in 226 adult subjects with rheumatoid arthritis who were treated with adalimumab or placebo.
Croatian: Sličan odgovor protutijela na standardno 23-valentno pneumokokno cjepivo i trovalentno cjepivo protiv gripe zamijećeno je u ispitivanju 226 odraslih ispitanika s reumatoidnim artritisom koji su primali adalimumab ili placebo.
English: Fever, bruising, bleeding or looking pale
Croatian: Vrućica, modrice, krvarenje ili blijed izgled
English: 5 years.
Croatian: 4 godine.
English: • Hefiya should only be used during a pregnancy if needed.
Croatian: • Hefiya se tijekom trudnoće smije primjenjivati samo ako je to neophodno.
English: Should treatment be interrupted, Hefiya may be re-introduced as appropriate.
Croatian: Ako liječenje treba privremeno prekinuti, Hefiya se kasnije po potrebi može ponovno uvesti.
English: Paraesthesias (including hypoaesthesia), migraine, nerve root compression
Croatian: Parestezije (uključujući hipoesteziju), migrena, kompresija korijena živca
English: After two further weeks, continue with a dosage of 40 mg every week or 80 mg every other week, as prescribed by your doctor.
Croatian: Nakon sljedeća dva tjedna liječenje se nastavlja doziranjem od 40 mg svaki tjedan ili 80 mg svaki drugi tjedan, kako je propisao Vaš liječnik.
English: Table 8 ACR responses in RA study V (percent of patients)
Croatian: Tablica 8 ACR odgovori u ispitivanju RA V (postotak bolesnika)
English: In the open-label extension for RA study V, ACR response rates were maintained when followed for up to 10 years.
Croatian: U otvorenom produžetku ispitivanja RA V, stope ACR odgovora održale su se tijekom praćenja u trajanju do 10 godina.
English: • For a more comfortable injection, take your pen out of the refrigerator 15 to 30 minutes before injecting Hefiya to allow it to reach room temperature.
Croatian: • Radi ugodnije injekcije, izvadite brizgalicu iz hladnjaka 15 do 30 minuta prije ubrizgavanja lijeka Hefiya kako bi mogla doseći sobnu temperaturu.
English: These therapies include methotrexate, leflunomide, hydroxychloroquine, sulfasalazine and / or gold salts.
Croatian: Ove terapije uključuju metotreksat, leflunomid, hidroksiklorokin, sulfasalazin i/ili soli zlata.
English: Improvement in health-related quality of life and physical function was maintained during the open- label extension through week 156.
Croatian: Poboljšanje kvalitete života vezane uz zdravlje i fizičke funkcije održalo se tijekom otvorenog produžetka ispitivanja do 156. tjedna.
English: Of the 371 remaining patients, 276 evaluable patients reached 78 weeks of open-label adalimumab treatment.
Croatian: Od preostalog 371 bolesnika, 276 ocjenjivih bolesnika sudjelovalo je u otvorenom liječenju adalimumabom tijekom 78 tjedana.
English: Preclinical data on postnatal toxicity of adalimumab are not available (see section 5.3).
Croatian: Nisu dostupni pretklinički podaci o postnatalnoj toksičnosti adalimumaba (vidjeti dio 5.3).
English: Carriers of HBV who require treatment with Hefiya should be closely monitored for signs and symptoms of active HBV infection throughout therapy and for several months following termination of therapy.
Croatian: Nositelje HBV-a u kojih je nužna primjena lijeka Hefiya mora se pomno pratiti zbog moguće pojave znakova i simptoma aktivne HBV infekcije tijekom cijelog trajanja terapije te nekoliko mjeseci nakon njezina prekida.
English: - Keep this leaflet.
Croatian: Sačuvajte ovu uputu.
English: The pivotal controlled studies involved 6,089 patients receiving adalimumab and 3,801 patients receiving placebo or active comparator during the controlled period.
Croatian: Pivotalna kontrolirana ispitivanja uključivala su 6089 bolesnika liječenih adalimumabom i 3801 bolesnika koji je primao placebo ili neki aktivni usporedni lijek tijekom kontroliranog razdoblja.
English: Adults with psoriasis
Croatian: Odrasli sa psorijazom
English: Skin cancer excluding melanoma (including basal cell carcinoma and squamous cell carcinoma) benign neoplasm
Croatian: Rak kože, isključujući melanom (uključujući bazocelularni karcinom i karcinom skvamoznih stanica), benigne neoplazme
English: • cancer, including cancer that affects the lymph system (lymphoma) and melanoma (a type of skin cancer);
Croatian: • rak, uključujući rak koji zahvaća limfni sustav (limfom) i melanom (vrsta raka kože),
English: Hefiya is used to treat polyarticular juvenile idiopathic arthritis in children and adolescents aged 2 to 17 years and enthesitis-related arthritis in children and adolescents aged 6 to 17 years.
Croatian: Hefiya je namijenjen liječenju poliartikularnog juvenilnog idiopatskog artritisa u djece i adolescenata u dobi od 2 do 17 godina i artritisa povezanog s entezitisom u djece i adolescenata u dobi od 6 do 17 godina.
English: Full instructions for use are given in the package leaflet, section 7, "Instructions for Use".
Croatian: Iscrpne upute za uporabu nalaze se u uputi o lijeku, dio 7 “Upute za uporabu“.
English: 73 % of patients enrolled in Psoriasis Studies I and II had received prior systemic therapy or phototherapy.
Croatian: Psoriasis Study I i II73% uključenih bolesnika prethodno je primalo sistemsku terapiju ili fototerapiju.
English: Do not remove the finger flange before the injection.
Croatian: Ne skidajte hvatište za prste prije injekcije.
English: Crohn's disease in adults and children
Croatian: Crohnova bolest u odraslih i djece
English: If you stop using Hefiya
Croatian: Ako prestanete uzimati lijek Hefiya
English: An embryo-foetal developmental toxicity / perinatal developmental study has been performed in cynomolgus monkeys at 0, 30 and 100 mg / kg (9-17 monkeys / group) and has revealed no evidence of harm to the foetuses due to adalimumab.
Croatian: Ispitivanja embriofetalne i perinatalne razvojne toksičnosti provedena na makaki majmunima s dozama od 0, 30 i 100 mg/kg (9-17 majmuna u skupini) nisu pokazala znakove oštećenja fetusa uslijed primjene adalimumaba.
English: Figure B: items not included in the carton See “4.
Croatian: Slika B: pribor koji se ne nalazi u kutiji Vidjeti “4.
English: Juvenile idiopathic arthritis (JIA)
Croatian: Juvenilni idiopatski artritis (JIA)
English: No clinical exposure data are available on the use of a loading dose in children < 6 years.
Croatian: Nema dostupnih kliničkih podataka o izloženosti kod primjene udarne doze u djece u dobi od < 6 godina.
English: • hearing loss, buzzing;
Croatian: • gubitak sluha, zujanje,
English: Study HS-II (PIONEER II) evaluated 326 patients with 2 treatment periods.
Croatian: Ispitivanje HS-II (PIONEER II) ocjenjivalo je 326 bolesnika tijekom 2 razdoblja liječenja.
English: - Your doctor will also give you a Patient Reminder Card, which contains important safety information that you need to be aware of before you are given Hefiya and during treatment with Hefiya.
Croatian: Liječnik će Vam također dati Karticu s podsjetnikomza bolesnika, koja sadrži važne podatke o sigurnosti s kojima morate biti upoznati prije i za vrijeme liječenja lijekom Hefiya.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING INNER CARTON OF MULTIPACK (WITHOUT BLUE BOX)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU UNUTARNJA KUTIJA VIŠESTRUKOG PAKIRANJA (BEZ PLAVOG OKVIRA)
English: week 52
Croatian: 52. tjedan
English: Patients treated with adalimumab usually experienced improvement in haematological signs of chronic inflammation.
Croatian: Bolesnici liječeni adalimumabom obično pokazuju poboljšanje hematoloških znakova kronične upale.
English: Women of childbearing potential should consider the use of adequate contraception to prevent pregnancy and continue its use for at least five months after the last Hefiya treatment.
Croatian: Žene reproduktivne dobi trebaju razmotriti korištenje odgovarajuće kontracepcije kako bi spriječile trudnoću i trebale bi je nastaviti koristiti još najmanje pet mjeseci nakon posljednje doze lijeka Hefiya.
English: At week 16, a statistically significantly greater proportion of patients who received adalimumab achieved PGA of 'clear' or 'almost clear' for the hands and/or feet compared to patients who received placebo (30.6% versus 4.3 %, respectively [P = 0.014]).
Croatian: U 16. tjednu je statistički značajno veći udio bolesnika koji su primali adalimumab postigao PGA rezultat „bez bolesti“ ili „gotovo bez bolesti“ za šake i/ili stopala u usporedbi s bolesnicima koji su primali placebo (30,6% u odnosu na 4,3% [P = 0,014]).
English: Psychiatric disorders
Croatian: Psihijatrijski poremećaji
English: There were no distinct differences between adalimumab-treated and untreated women for the secondary endpoints spontaneous abortions, minor birth defects, preterm delivery, birth size and serious or opportunistic infections and no stillbirths or malignancies were reported.
Croatian: Nije bilo velikih razlika između žena liječenih adalimumabom i onih koje ga nisu primale s obzirom na sekundarne mjere ishoda - spontane pobačaje, male (minor) urođene mane, prijevremeni porođaj, porođajnu veličinu i ozbiljne ili oportunističke infekcije, a nije prijavljeno nijedno mrtvorođenje ni zloćudna bolest.
English: Figure H: start your injection
Croatian: Slika H: započnite injekciju
English: The target of adalimumab is another protein called tumour necrosis factor (TNFα), which is present at increased levels in the inflammatory diseases listed above.
Croatian: Ciljna tvar za koju se vezuje adalimumab je protein pod nazivom faktor tumorske nekroze (TNFα), čije su razine kod gore navedenih upalnih bolesti povišene.
English: Table 28 response, remission and mucosal healing in study UC-II (percent of patients)
Croatian: Tablica 28 Odgovor, remisija i cijeljenje sluznice u ispitivanju UC-II (postotak bolesnika)
English: Psoriasis Study II (CHAMPION) compared the efficacy and safety of adalimumab versus methotrexate and placebo in 271 patients.
Croatian: U ispitivanju Psoriasis Study II (CHAMPION) uspoređivale su se djelotvornost i sigurnost adalimumaba u odnosu na metotreksat i placebo u 271 bolesnika.
English: Table 12 ped ACR 30 responses in the JIA study stratum
Croatian: Tablica 12 Pedijatrijski odgovori ACR 30 u ispitivanju kod JIA
English: There is limited experience in the initiation of treatment with adalimumab alone.
Croatian: Iskustvo sa započinjanjem liječenja samo adalimumabom je ograničeno.
English: At week 12, a significantly higher proportion of patients in Study HS-II experienced a clinically relevant decrease in HS-related skin pain (see table 21).
Croatian: U 12. je tjednu značajno veći udio bolesnika u ispitivanju HS-II doživio klinički značajno smanjenje kožne boli uzrokovane gnojnim hidradenitisom (vidjeti tablicu 21).
English: • systemic lupus erythematosus (an immune disorder including inflammation of skin, heart, lung,
Croatian: • sistemski eritemski lupus (imunološki poremećaj koji uključuje upalu kože, srca, pluća,
English: Your doctor may recommend temporarily stopping Hefiya.
Croatian: Liječnik može preporučiti privremeni prekid terapije lijekom Hefiya.
English: Failure to respond to treatment for Crohn's disease may indicate the presence of fixed fibrotic stricture that may require surgical treatment.
Croatian: Opstrukcija tankog crijeva Neuspješan odgovor na terapiju za Crohnovu bolest može biti znak fiksne fibrozne strikture koju je možda potrebno kirurški liječiti.
English: With the current knowledge, a possible risk for the development of lymphomas, leukaemia, and other malignancies in patients treated with a TNF-antagonist cannot be excluded.
Croatian: Prema postojećim saznanjima, mogući rizik od razvoja limfoma, leukemija i ostalih zloćudnih bolesti u bolesnika liječenih antagonistima TNF-a ne može se isključiti.
English: • If you have or develop demyelinating disease (a disease that affects the insulating layer around the nerves, such as multiple sclerosis), your doctor will decide if you should receive or continue to receive Hefiya.
Croatian: • Ako bolujete ili obolite od demijelinizirajuće bolesti (bolest koja zahvaća izolirajući sloj oko živaca, poput multiple skleroze), odluku o tome smijete li početi ili nastaviti primati lijek Hefiya donijet će Vaš liječnik.
English: • nerve disorders (such as inflammation of the optic nerve to the eye, and Guillain-Barré syndrome, a condition that may cause muscle weakness, abnormal sensations, tingling in the arms and upper body);
Croatian: • poremećaji živaca (kao što je upala očnog živca i Guillain-Barréov sindrom, bolest koja može uzrokovati slabost mišića, abnormalne osjete, trnce u rukama i gornjem dijelu tijela),
English: TNF-antagonists including adalimumab have been associated in rare instances with new onset or exacerbation of clinical symptoms and / or radiographic evidence of central nervous system demyelinating disease including multiple sclerosis and optic neuritis, and peripheral demyelinating disease, including Guillain-Barré syndrome.
Croatian: U rijetkim su slučajevima antagonisti TNF-a, uključujući adalimumab, bili povezani s pojavom novih ili pogoršanjem postojećih kliničkih simptoma i/ili radiografskih dokaza demijelinizirajuće bolesti središnjeg živčanog sustava, uključujući multiplu sklerozu i optički neuritis, i periferne demijelinizirajuće bolesti, uključujući Guillain-Barréov sindrom.
English: Leucocytosis, thrombocytopaenia
Croatian: Leukocitoza, trombocitopenija
English: Improved physical function continued during the open label extension up to week 136.
Croatian: Poboljšana fizička funkcija održala se i u otvorenom produžetku ispitivanja do 136. tjedna.
English: Investigations*
Croatian: Pretrage*
English: The distribution of patients by age and minimum, median and maximum dose received during the OL LI phase is presented in table 11.
Croatian: Raspored bolesnika prema dobi te minimalnoj i maksimalnoj dozi i medijanu doze tijekom ove faze prikazan je u tablici 11.
English: This evaluation should include a detailed medical assessment of patient history of tuberculosis or possible previous exposure to people with active tuberculosis and previous and/or current immunosuppressive therapy.
Croatian: Te pretrage moraju obuhvaćati detaljnu ocjenu bolesnikove anamneze s obzirom na tuberkulozu ili eventualne ranije izloženosti osobama s aktivnom tuberkulozom te prijašnje i/ili sadašnje liječenje imunosupresivnim lijekovima.
English: • Keep holding your pen firmly against your skin.
Croatian: • Nastavite držati brizgalicu čvrsto pritisnutu na kožu.
English: If you have mild heart failure and you are being treated with Hefiya, your heart failure status must be closely monitored by your doctor.
Croatian: Bolujete li od blagog zatajenja srca, a liječite se lijekom Hefiya, liječnik mora pomno nadzirati status zatajenja srca.
English: Of those patients who had a response at week 8, 47 % were in response, 29 % were in remission, 41 % had mucosal healing, and 20 % were in steroid-free remission for ≥ 90 days at week 52.
Croatian: Od bolesnika koji su imali odgovor u 8. tjednu, 47% ih je postiglo klinički odgovor, 29% ih je bilo u remisiji, a 41% je imalo zacjeljivanje sluznice, dok ih je u 52. tjednu 20% bilo u remisiji bez primjene steroida ≥ 90 dana.
English: Diagnosis and administration of empiric antifungal therapy in these patients should be made in consultation with a physician with expertise in the care of patients with invasive fungal infections.
Croatian: U ovih bolesnika dijagnozu i primjenu empirijske antifungalne terapije potrebno je provesti uz savjetovanje s liječnikom koji ima iskustva u liječenju bolesnika s invazivnim gljivičnim infekcijama.
English: Throughout all 3 studies patients used topical antiseptic wash daily.
Croatian: Tijekom sva 3 ispitivanja bolesnici su svakodnevno koristili topikalnu antiseptičku tekućinu.
English: Available data suggest that the clinical response is usually achieved within 2-8 weeks of treatment.
Croatian: Dostupni podaci upućuju na to da se klinički odgovor obično postiže unutar 2-8 tjedana liječenja.
English: Given orally, immunoglobulin G proteins undergo intestinal proteolysis and have poor bioavailability.
Croatian: Kada se primjenjuju peroralno, imunoglobulin G proteini prolaze proteolizu u crijevima te imaju malu bioraspoloživost.
English: In Study UV I statistically significant differences in favour of adalimumab versus placebo were observed for each component of treatment failure.
Croatian: U ispitivanju UV I primijećene su statistički značajne razlike u korist adalimumaba naspram placeba za svaku komponentu neuspjeha liječenja.
English: • Hold your pen at 90 degrees to the cleaned injection site (see Figure G).
Croatian: • Držite brizgalicu pod kutom od 90 stupnjeva u odnosu na očišćeno mjesto primjene (vidjeti Sliku G).
English: You should continue to inject Hefiya for as long as your doctor has told you.
Croatian: Nastavite injicirati lijek Hefiya onoliko dugo koliko Vam kaže liječnik.
English: • heart problems that can cause shortness of breath or ankle swelling;
Croatian: • problemi sa srcem koji mogu uzrokovati nedostatak zraka ili oticanje zglobova,
English: Do not use the syringe if the expiration date has passed.
Croatian: Ne koristite štrcaljku ako je rok valjanosti istekao.
English: N/A
Croatian: N/P
English: Hidradenitis suppurativa in adults and adolescents
Croatian: Gnojni hidradenitis (Hidradenitis suppurativa) u odraslih i adolescenata
English: • signs and symptoms suggestive of blood disorders such as persistent fever, bruising, bleeding,
Croatian: • znakove i simptome koji upućuju na poremećaje u krvi poput uporne vrućice, stvaranja modrica,
English: If such a dose is required, other adalimumab medicines should be used.
Croatian: Ako je takva doza potrebna, mogu se koristiti drugi lijekovi koji sadrže adalimumab.
English: Study UV I evaluated 217 patients with active uveitis despite treatment with corticosteroids (oral prednisone at a dose of 10 to 60 mg / day).
Croatian: Ispitivanje UV I ocjenjivalo je 217 bolesnika s aktivnim uveitisom unatoč liječenju kortikosteroidima (oralni prednizon u dozi od 10 do 60 mg/dan).
English: 10, 20 and 25 mg
Croatian: 10, 20 i 25 mg
English: Patients may first be given other disease-modifying medicines, such as methotrexate.
Croatian: Moguće je da će bolesnicima prvo biti propisani drugi lijekovi koji mijenjaju tijek bolesti, kao što je metotreksat.
English: Haematologic reactions
Croatian: Hematološke reakcije
English: Reactivation of hepatitis B has occurred in patients receiving a TNF-antagonist including adalimumab, who are chronic carriers of this virus (i.e. surface antigen positive).
Croatian: Reaktivacija hepatitisa B Zabilježena je reaktivacija hepatitisa B u bolesnika koji su uzimali antagoniste TNF-a, uključujući adalimumab, i koji su bili su kronični nositelji tog virusa (tj. pozitivni na površinski antigen), a bilo je i slučajeva sa smrtnim ishodom.
English: Among the 68 patients who flared in the group allocated to treatment withdrawal, 65 completed 12 weeks of rescue therapy with adalimumab, out of which 37 (56.9%) had regained remission (ASDAS < 1.3) after 12 weeks of restarting the open-label treatment.
Croatian: Među 68 bolesnika kod kojih je došlo do egzacerbacije u skupini u kojoj je terapija ukinuta, 65 bolesnika primilo je 12 tjedana spasonosne terapije adalimumabom, od kojih je njih 37 (56,9%) ponovno postiglo remisiju bolesti (ASDAS rezultat < 1,3) 12 tjedana nakon ponovnog započinjanja otvorenog liječenja.
English: • As cases of tuberculosis have been reported in patients treated with adalimumab, your doctor will check you for signs and symptoms of tuberculosis before starting Hefiya.
Croatian: • Budući da su u bolesnika liječenih adalimumabom prijavljeni slučajevi tuberkuloze, prije nego počnete s liječenjem lijekom Hefiya, liječnik će provjeriti imate li znakove i simptome tuberkuloze.
English: Leave it to dry before injecting (see Figure F).
Croatian: Pustite da se osuši prije primjene injekcije (vidjeti Sliku F).
English: adalimumab / M TX n = 268
Croatian: adalimumab / MTX n=268
English: Non-infectious uveitis is an inflammatory disease affecting certain parts of the eye.
Croatian: Nezarazni uveitis je upalna bolest koja zahvaća određene dijelove oka.
English: • mood swings (including depression);
Croatian: • promjene raspoloženja (uključujući depresiju),
English: Hefiya can be given as monotherapy in case of intolerance to methotrexate or when continued treatment with methotrexate is inappropriate (for the efficacy in monotherapy see section 5.1).
Croatian: Hefiya se može davati kao monoterapija u slučajevima nepodnošenja metotreksata ili kada nastavak terapije metotreksatom nije prikladan (za djelotvornost monoterapije vidjeti dio 5.1).
English: You should not take Hefiya with medicines containing the active substances anakinra or abatacept due to increased risk of serious infection.
Croatian: Hefiya se ne smije primjenjivati s lijekovima koji sadrže djelatne tvari anakinru ili abatacept zbog povećanog rizika od ozbiljne infekcije.
English: In a clinical trial with another TNF-antagonist worsening congestive heart failure and increased mortality due to congestive heart failure have been observed.
Croatian: U kliničkom ispitivanju jednog drugog antagonista TNF-a zabilježeno je pogoršanje kongestivnog zatajenja srca i povećana smrtnost zbog kongestivnog zatajenja srca.
English: During the study, most subjects used concomitant MTX, with fewer reporting use of corticosteroids or NSAIDs.
Croatian: Tijekom ispitivanja, većina ispitanika je istodobno uzimala metotreksat, a nekolicina je prijavila primjenu kortikosteroida ili NSAIL-a.
English: Cholecystitis and cholelithiasis, hepatic steatosis, bilirubin increased
Croatian: Manje često Kolecistitis i kolelitijaza, steatoza jetre, povišen bilirubin
English: Plaque psoriasis in adults and children
Croatian: Plak psorijaza u odraslih i djece
English: Metabolism and nutrition disorders
Croatian: Poremećaji metabolizma i prehrane
English: A total of 233 PASI 75 responders at week 16 and week 33 received continuous adalimumab therapy for 52 weeks in Psoriasis Study I, and continued adalimumab in the open-label extension trial.
Croatian: Ukupno su 233 bolesnika s odgovorom PASI 75 u 16. i 33. tjednu primala kontinuiranu terapiju adalimumabom kroz 52 tjedna u ispitivanju Psoriasis Study I te su nastavila s primanjem adalimumaba u otvorenom produžetku ispitivanja.
English: These include rare reports of pancytopenia, aplastic anaemia, central and peripheral demyelinating events and reports of lupus, lupus-related conditions and Stevens-Johnson syndrome.
Croatian: One uključuju rijetke prijave pancitopenije, aplastične anemije, demijelinizirajućih događaja u središnjem i perifernom živčanom sustavu te prijave lupusa, stanja povezanih s lupusom i Stevens-Johnsonova sindroma.
English: • Do not touch the cleaned area before injecting.
Croatian: • Ne dirajte očišćeno područje prije primjene injekcije.
English: Hefiya may have a minor influence on the ability to drive and use machines.
Croatian: Hefiya može imati mali utjecaj na sposobnost upravljanja vozilima i rada sa strojevima.