FrancophonIA/ELRC3.0 huggingface dataset:
English: Your first treatment will be given to you in a hospital.
Slovenian: Zdravljenje se bo začelo v bolnišnici.
English: Injection:
Slovenian: Injekcija:
English: Bleeding risk was defined as: • Very high risk - presence of active bleeding at the time of dialysis initiation
Slovenian: Tveganje za krvavitev je bilo opredeljeno kot: • Zelo veliko tveganje - prisotnost aktivne krvavitve v času začetka dialize
English: • increase in sugar (glucose) in the blood
Slovenian: • zvišanje sladkorja (glukoze) v krvi.
English: Reconstitution and dilution should be carried out immediately prior to use (see section 4.2, section 6.3 and Section 6.6).
Slovenian: Pripravo in razredčenje je treba opraviti tik pred uporabo (glejte poglavja 4.2, 6.3 in 6.6).
English: Improvements were apparent in some patients at the end of the first week of therapy.
Slovenian: Izboljšanja so bila pri nekaterih bolnikih opazna že ob koncu prvega tedna zdravljenja.
English: However, 9 of 27 epoprostenol dialyses were unsuccessful following multiple attempts.
Slovenian: Toda 9 od 27 dializ z epoprostenolom ni bilo uspešnih niti po več poskusih.
English: This is because your doctor needs to monitor you and find the best dose for you.
Slovenian: Zdravnik vas mora namreč kontrolirati in vam določiti najprimernejši odmerek.
English: Tell your doctor or nurse immediately, as these may be signs of infection of the blood or low blood pressure or serious bleeding:
Slovenian: Svojemu zdravniku ali medicinski sestri morate nemudoma povedati za naslednje težave, kajti te težave so lahko znaki okužbe krvi, nizkega krvnega tlaka ali resne krvavitve:
English: • if you are allergic to Flolan or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični na zdravilo Flolan ali katero koli sestavino tega zdravila (navedeno v poglavju 6),
English: Given the absence of alternative medicines, epoprostenol can be used in those women who choose to continue their pregnancy, despite the known risk of pulmonary arterial hypertension during pregnancy.
Slovenian: Glede na to, da alternativnih zdravil ni, se epoprostenol lahko uporablja pri tistih ženskah, ki želijo nosečnost nadaljevati kljub znanim tveganjem pljučne arterijske hipertenzije med nosečnostjo.
English: Extreme caution is advised in patients with coronary artery disease.
Slovenian: Skrajna previdnost je potrebna pri bolnikih z boleznijo koronarnih arterij.
English: Your doctor or nurse will show you how to clean your ‘line' and the area around it.
Slovenian: Zdravnik ali medicinska sestra vam bosta pokazala, kako očistiti kateter in predel okrog njega.
English: Your doctor will decide how much Flolan is right for you.
Slovenian: Zdravnik bo odločil, kolikšna količina zdravila Flolan je primerna za vas.
English: Frequencies are defined as follows: very common ≥1/10 (≥10%); common ≥1/100 and <1/10 (≥1% and <10%); uncommon ≥1/1000 and <1/100 (≥0.1% and <1%); rare ≥1/10,000 and <1/1000 ( ≥0.01% and <0.1%); very rare <1/10,000 (< 0.01%) and not known (cannot be estimated from the available data).
Slovenian: Opredelitev pogostnosti je: zelo pogosti ≥1/10 (≥10 %), pogosti ≥1/100 in < 1/10 (≥1 % in < 10 %), občasni ≥ 1/1000 in <1/100 ( ≥ 0,1 % in < 1 %), redki ≥ 1/10.000 in < 1/1000 ( ≥0,01 % in < 0,1 %), zelo redki < 1/10.000 (< 0,01 %) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: It is also a potent vasodilator.
Slovenian: Je tudi močan vazodilatator.
English: 4.6 Fertility, pregnancy,and lactation
Slovenian: 4.6 Plodnost, nosečnost in dojenje
English: Local infection*
Slovenian: Redki lokalna okužba*
English: It is important that the medicine does not leak out of the vein into the surrounding tissue.
Slovenian: Pomembno je, da zdravilo ne pronica iz vene v okoliško tkivo.
English: • if you have any problems with bleeding.
Slovenian: • če imate kakšne težave s strjevanjem krvi (krvavitvami).
English: These haemodynamic improvements appeared to persist when epoprostenol was administered for at least 36 months in an open, nonrandomized study.
Slovenian: Ta hemodinamska izboljšanja so se ohranila, ko je bil epoprostenol vsaj 36 mesecev uporabljan v odprti, nerandomizirani študiji.
English: Following the administration of radiolabelled epoprostenol to humans, at least 16 metabolites were found, 10 of which were structurally identified.
Slovenian: Po uporabi radioaktivno označenega epoprostenola pri človeku so ugotovili vsaj 16 presnovkov; 10 od teh je strukturno opredeljenih.
English: INFORMATION FOR HEALTHCARE PROFESSIONALS
Slovenian: INFORMACIJE ZA ZDRAVSTVENO OSEBJE
English: The infusion should be stopped at the end of dialysis.
Slovenian: Infundiranje je treba končati ob koncu dialize.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine as your symptoms could worsen during pregnancy.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte s svojim zdravnikom, preden vzamete to zdravilo, kajti simptomi se vam lahko med nosečnostjo poslabšajo.
English: Most epoprostenol dialyses (67%) that required replacement of artificial kidney were completed subsequently with epoprostenol without clotting.
Slovenian: Večino dializ z epoprostenolom (67 %), ki so zahtevale zamenjavo umetne ledvice, so nato dokončali z epoprostenolom brez strjevanja.
English: • if you start to develop a build-up of fluid in your lungs causing breathlessness after starting this treatment.
Slovenian: • če se vam začne v pljučih kopičiti tekočina; to povzroči težko dihanje po začetku tega zdravljenja.
English: Using Flolan at home (only for treatment of Pulmonary Arterial Hypertension) If you are treating yourself at home, your doctor or nurse will show you how to prepare and use Flolan.
Slovenian: Uporaba zdravila Flolan doma (samo za zdravljenje pljučne arterijske hipertenzije) Če se zdravite sami doma, vam bosta zdravnik ali medicinska sestra pokazala, kako pripraviti in uporabiti zdravilo Flolan.
English: • for a maximum of 8 hours if it was made previously and has been stored at 2-8oC.
Slovenian: • največ 8 ur, če je bila pripravljena že prej in je bila shranjena pri temperaturi od 2 do 8 oC.
English: Those patients who continued to bleed were evaluated for changes in bleeding severity.
Slovenian: Bolnike, ki so krvaveli še naprej, so ocenili glede sprememb v resnosti krvavitev.
English: Tachycardia2, bradycardia3,
Slovenian: Srčne bolezni Pogosti tahikardija2, bradikardija3
English: • infection of the blood (septicaemia)
Slovenian: • okužba krvi (septikemija),
English: This should be carried out according to the instructions given for renal dialysis.
Slovenian: Opraviti jo je treba v skladu z navodili, navedenimi za ledvično dializo.
English: The cardiovascular effects during infusion disappear within 30 min of the end of administration.
Slovenian: Kardiovaskularni učinki, ki se pojavijo med infundiranjem, izginejo v 30 minutah po koncu dajanja zdravila.
English: Long-term continuous infusion:
Slovenian: Dolgotrajno stalno infundiranje:
English: This may be followed by blistering and shedding of the skin.
Slovenian: Sledi lahko nastanek mehurjev in lupljenje kože.
English: Reconstitution and dilution of Flolan must be carried out under aseptic conditions, immediately prior to clinical use.
Slovenian: Pripravo in razredčenje zdravila Flolan je treba opraviti v aseptičnih pogojih, tik pred klinično uporabo.
English: If you think any of these apply to you, don't take Flolan until you have checked with your doctor.
Slovenian: Če menite, da kaj od tega velja za vas, ne jemljite zdravila Flolan, dokler se ne posvetujete s svojim zdravnikom.
English: The powder is white or off-white and the solution is clear and colourless.
Slovenian: Prašek je bele ali skoraj bele barve, raztopina pa je bistra in brezbarvna.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Slovenian: Obvestite svojega zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo; to velja tudi za zdravila, ki ste jih dobili brez recepta.
English: When Flolan is used alone, measurements such as activated whole blood clotting time may not be reliable.
Slovenian: Če je zdravilo Flolan uporabljeno samo, so meritve, kakršna je aktivirani čas strjevanja polne krvi, lahko nezanesljive.
English: Epoprostenol potentiates the anticoagulant activity of heparin by approximately 50%, possibly reducing the release of heparin neutralising factor.
Slovenian: Epoprostenol poveča antikoagulantno delovanje heparina za približno 50 % in morda zmanjša sproščanje faktorja, ki nevtralizira heparin.
English: Improvements were apparent as early as the first week of therapy.
Slovenian: Izboljšanja so bila opazna že po prvem tednu zdravljenja.
English: Dosage adjustments:
Slovenian: Prilagoditve odmerjanja:
English: The infusion rate may be calculated from the following formula:
Slovenian: Hitrost infundiranja je mogoče izračunati po naslednji formuli:
English: If you have any of the liquid left over, it must be thrown away.
Slovenian: Če kaj te tekočine ostane, jo morate zavreči.
English: Pharmacotherapeutic group: Antithrombotic Agents; Platelet aggregation inhibitors excl. heparin, ATC code: B01AC09
Slovenian: Farmakoterapevtska skupina: antitrombotiki, zaviralci agregacije trombocitov brez heparina, oznaka ATC: B01AC09
English: Short-term (acute) dose ranging:
Slovenian: Kratkotrajno (akutno) ugotavljanje odmerka:
English: The symptoms of low blood pressure include dizziness and fainting.
Slovenian: Med simptomi nizkega krvnega tlaka sta omotica in omedlevica.
English: Flow rates in mL/h b. Diluted: A commonly used dilution is:
Slovenian: Hitrost pretoka v ml/h b. Razredčeno: Pogosto uporabljeno razredčenje je:
English: If you forget to take Flolan Do not take a double dose to make up for a forgotten dose.
Slovenian: Če ste pozabili vzeti zdravilo Flolan Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
English: The effects of epoprostenol on mean pulmonary artery pressure (PAPm) in patients with PPH were variable and minor.
Slovenian: Učinki epoprostenola na srednji pljučni arterijski tlak (PAPm - mean pulmonary artery pressure) pri bolnikih s PPH so bili spremenljivi in majhni.
English: The liquid does not contain a preservative.
Slovenian: Ta tekočina ne vsebuje konzervansa.
English: What Flolan is and what it is used for
Slovenian: Kaj je zdravilo Flolan in za kaj ga uporabljamo
English: Sodium Chloride
Slovenian: Natrijev klorid
English: Before you are given Flolan your doctor needs to know:
Slovenian: Preden dobite zdravilo Flolan, morate zdravniku povedati:
English: There is a limited amount of data from the use of epoprostenol in pregnant women.
Slovenian: Podatkov o uporabi epoprostenola pri nosečnicah je malo.
English: Animal studies did not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3).
Slovenian: Študije na živalih niso pokazale neposrednih ali posrednih škodljivih učinkov glede reproduktivne toksičnosti (glejte poglavje 5.3).
English: Talk to your doctor or pharmacist or nurse about any other side effects, including those not listed in this leaflet.
Slovenian: S svojim zdravnikom, farmacevtom ali medicinsko sestro se posvetujte tudi o vseh drugih neželenih učinkih, vključno s tistimi, ki niso omenjeni v tem navodilu.
English: • High risk - having had within 3 days prior to dialysis an active bleed that stopped at the pre-dialysis phase; or having incurred surgical or traumatic wounds within 3 days prior to dialysis
Slovenian: • Veliko tveganje - aktivna krvavitev v 3 dneh pred dializo, ki se je ustavila v preddializni fazi, ali kirurške ali travmatske rane v 3 dneh pred dializo
English: Elevated serum glucose levels have been reported (see section 4.8).
Slovenian: Opisano je bilo zvišanje koncentracije glukoze v serumu (glejte poglavje 4.8).
English: Powder for solution for infusion: Mannitol
Slovenian: Prašek za raztopino za infundiranje: Manitol
English: The cold pouch must be regularly changed throughout the day, to maintain the temperature of the solution.
Slovenian: Hladno vrečko je treba čez dan redno menjavati, da se temperatura raztopine ohrani.
English: The recommended dose for renal dialysis should be exceeded only with careful monitoring of patient blood pressure.
Slovenian: Priporočeni odmerek za ledvično dializo je dovoljeno preseči le ob natančnem kontroliranju bolnikovega krvnega tlaka.
English: Abrupt withdrawal or interruption of infusion must be avoided, except in life-threatening situations.
Slovenian: Izogibati se moramo nenadnemu prenehanju ali prekinitvi infundiranja , razen v življenjsko nevarnih okoliščinah.
English: The main feature of overdose is likely to be hypotension.
Slovenian: Verjetno je, da je glavna značilnost prevelikega odmerjanja hipotenzija.
English: There are no data on the effects of epoprostenol on fertility in humans.
Slovenian: Podatkov o vplivu epoprostenola na plodnost pri človeku ni.
English: Due to the chemical instability, high potency and short half-life of epoprostenol, no precise and accurate assay has been identified as appropriate for quantifying epoprostenol in biological fluids.
Slovenian: Zaradi kemične nestabilnosti, velike učinkovitosti in kratkega razpolovnega časa epoprostenola, natančen preizkus za kvantificiranje epoprostenola v bioloških tekočinah ni znan.
English: Adverse events are listed below by system organ class and frequency.
Slovenian: Neželeni učinki so navedeni spodaj po organskih sistemih in pogostnosti.
English: If you have problems with the infusion pump or injection line that stops, or prevents treatment with Flolan, contact your doctor, nurse or hospital immediately.
Slovenian: Če imate z infuzijsko črpalko ali injekcijskim katetrom težave, ki prekinejo ali preprečijo zdravljenje z zdravilom Flolan, se nemudoma obrnite na svojega zdravnika, medicinsko sestro ali bolnišnico.
English: Any cold pouch used must be capable of maintaining the temperature of the reconstituted solution.
Slovenian: Vsaka uporabljena hladna vrečka mora biti zmožna vzdrževati temperaturo pripravljene raztopine.
English: At the end of the treatment period, 4 of 56 (7%) patients receiving epoprostenol died, whereas 5 of 55 (9%) patients receiving conventional therapy alone died.
Slovenian: Na koncu obdobja zdravljenja so umrli 4 od 56 (7 %) prejemnikov epoprostenola in 5 od 55 (9 %) prejemnikov konvencionalnega zdravljenja samega.
English: Patients who did not have clear evidence of bleeding just prior to their first study dialysis, but who bled within 3 days prior were classified as high risk of haemorrhage.
Slovenian: Bolniki, ki niso imeli jasnih znakov krvavitve tik pred prvo študijsko dializo, a so krvaveli v 3 dneh prej, so bili uvrščeni med bolnike z velikim tveganjem za krvavitev.
English: Powder and Solvent for solution for infusion: 3 years.
Slovenian: Prašek in vehikel za raztopino za infundiranje: 3 leta.
English: Other medicines and Flolan
Slovenian: Druga zdravila in zdravilo Flolan
English: It is not known whether the ingredients of Flolan can pass into breast-milk.
Slovenian: Ni znano, ali lahko sestavine zdravila Flolan prehajajo v materino mleko.
English: Particular care should be taken in the preparation of the infusion and in calculating the rate of infusion.
Slovenian: Posebno skrb je treba nameniti pripravi infuzije in izračunu hitrosti infundiranja.
English: Solvent for parenteral use:
Slovenian: Vehikel za parenteralno uporabo:
English: Increases in exercise capacity were accompanied by statistically significant improvements in dyspnoea, as measured by the Borg Dyspnea Index.
Slovenian: Povečanje obremenitvene zmogljivosti je spremljalo statistično značilno izboljšanje dispneje, merjene z Borgovim indeksom dispneje.
English: Hypotension may be profound in overdose and may result in loss of consciousness (see section 4.9).
Slovenian: Hipotenzija je lahko v primeru prevelikega odmerjanja huda in lahko povzroči izgubo zavesti (glejte poglavje 4.9)
English: The symptoms of this are:
Slovenian: Simptomi so:
English: In general, the need for increases in dose from the initial long-term dose should be expected over time.
Slovenian: Pričakovati bi morali, da je treba začetni dolgotrajni odmerek sčasoma povečati.
English: If you are not using a ‘cold pouch', the solution can be stored in the pump:
Slovenian: Če ne uporabljate "hladne vrečke", imate raztopino lahko shranjeno v črpalki:
English: Unlike many other prostaglandins, epoprostenol is not metabolised during passage through the pulmonary circulation.
Slovenian: V nasprotju s številnimi drugimi prostaglandini se epoprostenol ne presnovi med prehodom skozi pljučni obtok.
English: Flolan is indicated for:
Slovenian: Zdravilo Flolan je indicirano pri:
English: If the treatment is stopped too quickly you may get serious side effects, including dizziness, feeling weak and breathing difficulties.
Slovenian: Če se zdravljenje konča prehitro, se vam lahko pojavijo resni neželeni učinki, med drugim omotica, šibkost in težave z dihanjem.
English: At the end of the treatment period in the 12 weeks study, survival was improved in NYHA functional Class III and Class IV patients.
Slovenian: Na koncu obdobja zdravljenja v 12-tedenski študiji se je preživetje bolnikov v III. in IV. funkcijskem razredu po NYHA izboljšalo.
English: Flolan can also affect how some other medicines work if taken at the same time.
Slovenian: Tudi zdravilo Flolan lahko vpliva na delovanje nekaterih zdravil, če je uporabljeno hkrati z njimi.
English: Pulmonary Arterial Hypertension
Slovenian: Pljučna arterijska hipertenzija
English: Primary measurements of efficacy included intradialytic removal of BUN and creatinine, intradialytic removal of fluid (ultrafiltration), and clotting within the extracorporeal circuit.
Slovenian: Med primarnimi meritvami učinkovitosti so bile intradializno odstranjevanje sečnine in kreatinina, intradializno odstranjevanje tekočine (ultrafiltracija) ter strjevanje v zunajtelesnem obtoku.
English: • medicines to treat inflammation or pain (also called ‘NSAIDs')
Slovenian: • zdravila za zdravljenje vnetij ali bolečin (imenujemo jih tudi nesteroidna protivnetna zdravila ali
English: • with congestive heart failure arising from severe left ventricular dysfunction.
Slovenian: • s kongestivnim srčnim popuščanjem, ki je posledica hude disfunkcije levega prekata,
English: If overdose occurs reduce the dose or discontinue the infusion and initiate appropriate supportive measures as necessary; for example plasma volume expansion and/or adjustment to pump flow.
Slovenian: V primeru prevelikega odmerjanja je treba zmanjšati odmerek ali prekiniti infundiranje in uporabiti ustrezne podporne ukrepe, kot je potrebno, npr. nadomeščanje volumna plazme in/ali prilagoditev pretoka črpalke.
English: Only this concentrated solution is suitable for further dilution prior to use.
Slovenian: Le ta koncentrirana raztopina je primerna za nadaljnje razredčenje pred uporabo.
English: • feeling anxious, feeling nervous
Slovenian: • občutek tesnobe, občutek živčnosti,
English: Flolan is not a conventional anticoagulant.
Slovenian: Zdravilo Flolan ni običajno antikoagulantno zdravilo.
English: Eight of 40 (20%) patients receiving conventional therapy alone died, whereas none of the 41 patients receiving epoprostenol died (p=0.003).
Slovenian: Umrlo je 8 od 40 (20 %) bolnikov, ki so prejemali samo konvencionalno zdravljenje, med 41 bolniki, ki so prejemali epoprostenol, pa ni umrl nobeden (p = 0,003).
English: Reproductive studies in animals have shown no effects on fertility (see section 5.3).
Slovenian: Študije o sposobnosti razmnoževanja pri živalih niso pokazale vpliva na plodnost (glejte poglavje 5.3).
English: The dose will be increased, until your symptoms are relieved, and any side effects are manageable.
Slovenian: Odmerek vam bo povečeval, dokler vam zdravilo ne bo olajšalo simptomov in dokler bodo neželeni učinki obvladljivi.
English: Each patient was randomly assigned to a sequence of heparin or epoprostenol dialyses and received up to 6 dialyses per entry in one study and up to 3 dialyses per entry in another study.
Slovenian: Vsakega bolnika so naključno razvrstili na zaporedje dializ s heparinom ali epoprostenolom in so bili deležni do 6 dializ na vstop v eni študiji in do 3 dializ na vstop v drugi študiji.
English: Flolan can cause your heart to beat faster or slower.
Slovenian: Zdravilo Flolan lahko povzroči, da začne srce biti hitreje ali počasneje.
English: For a full list of excipents, see section 6.1
Slovenian: Za celoten seznam pomožnih snovi glejte poglavje 6.1.
English: • bleeding at various sites and bruising more easily than normal, for example from the nose or gums
Slovenian: • krvavitev na različnih mestih ali večja nagnjenost k podplutbam kot ponavadi, npr. krvavitev iz nosu ali dlesni,
English: If you stop taking Flolan
Slovenian: Če ste prenehali jemati zdravilo Flolan
English: As reported with other prostaglandin analogues, Flolan may reduce the thrombolytic efficacy of tissue plasminogen activator (t-PA) by increasing hepatic clearance of t-PA.
Slovenian: Tako, kot je opisano pri drugih prostaglandinskih analogih, lahko tudi zdravilo Flolan zmanjša trombolitično učinkovitost tkivnega aktivatorja plazminogena (t-PA), in sicer s povečanjem jetrnega očistka t-PA.
English: At normal physiological pH and temperature, epoprostenol breaks down spontaneously to 6-oxoprostaglandin F1 alpha, although there is some enzymatic degradation to other products.
Slovenian: Pri normalnem fiziološkem pH in pri normalni temperaturi se epoprostenol spontano razgradi v 6-oksoprostaglandin F1 alfa, nekaj pa je tudi encimske razgradnje v druge snovi.
English: No long-term animal studies have been conducted to determine the carcinogenic potential of epoprostenol.
Slovenian: Dolgoročne študije za oceno kancerogenosti epoprostenola na živalih niso bile izvedene.
English: If excessive hypotension occurs during administration of Flolan, the dose should be reduced or the infusion discontinued.
Slovenian: Če se med dajanjem zdravila Flolan pojavi čezmerna hipotenzija, je treba odmerek zmanjšati ali infundiranje prekiniti.
English: Minor clotting (sufficient to require intervention, but not permanently suspending dialysis or requiring changing of the artificial kidney) was reported more frequently during epoprostenol than during heparin dialyses.
Slovenian: Manj pomembno strjevanje (tolikšno, da je zahtevalo ukrepanje, ne pa trajne prekinitve dialize ali potrebe po menjavi umetne ledvice) je bilo med dializami z epoprostenolom pogostejše kot med dializami s heparinom.
English: Changes in the long-term infusion rate should be based on persistence, recurrence or worsening of the patient's symptoms of pulmonary arterial hypertension or the occurrence of adverse reaction due to excessive doses of Flolan.
Slovenian: Spremembe v dolgotrajni hitrosti infundiranja morajo temeljiti na trajanju, ponovitvi ali poslabšanju bolnikovih simptomov pljučne arterijske hipertenzije ali pojavu neželenih učinkov zaradi čezmernih odmerkov zdravila Flolan.
English: A short-term dose-ranging procedure administered via either a peripheral or central venous line is required to determine the long-term infusion rate.
Slovenian: Postopek kratkotrajnega ugotavljanja odmerka po periferni ali centralni venski liniji je potreben za določitev hitrosti dolgotrajnega infundiranja.
English: The effects of Flolan on heart rate may be masked by concomitant use of drugs which affect cardiovascular reflexes.
Slovenian: Vplive zdravila Flolan na srčno frekvenco lahko prikrije sočasna uporaba zdravil, ki vplivajo na kardiovaskularne reflekse.
English: During renal dialysis with Flolan it should be ensured that the cardiac output increases more than minimally so that delivery of oxygen to peripheral tissue is not diminished.
Slovenian: Med ledvično dializo z uporabo zdravila Flolan je treba poskrbeti, da se minutni volumen srca poveča več kot le minimalno, tako da se oskrba perifernih tkiv s kisikom ne zmanjša.