FrancophonIA/ELRC3.0 huggingface dataset:
English: With Caelyx, the encapsulation of doxorubicin hydrochloride in pegylated liposomes results in these effects having a differing strength, as follows.
Danish: Med Caelyx resulterer indkapslingen af doxorubicin i pegylerede liposomer i,at disse virkninger har en anden styrke, som angivet nedenfor.
English: The most frequently reported (medicine-related treatment-emergent) adverse events in combination therapy (Caelyx + bortezomib) were nausea (40%), diarrhoea (35%), neutropaenia (33%), thrombocytopaenia (29%), vomiting (28%), fatigue (27%), and constipation (22%).
Danish: De hyppigst rapporterede bivirkninger (lægemiddelrelaterede behandlingsudløste) i kombinationsbehandling (Caelyx + bortezomib) var kvalme (40 %), diarre (35 %), neutropeni (33 %), trombocytopeni (29 %), opkastning (28 %), træthed (27 %) og forstoppelse (22 %).
English: This leaflet was last approved on
Danish: Denne indlægsseddel blev senest ændret
English: If tolerated, the infusion was completed over the next hour for a total infusion time of 90 minutes.
Danish: Hvis dette blev tålt, blev infusionen afsluttet i løbet af den næste time med en total infusionstid på 90 minutter.
English: Stomatitis was reported more frequently in the combination therapy group (16%) than in the monotherapy group (3%), and most cases were grade 2 or less in severity.
Danish: Stomatitis blev rapporteret hyppigere i gruppen, der fik kombinationsbehandling (16 %) end i monoterapi-gruppen (3 %), og de fleste tilfælde var grad 2 eller mindre i sværhedsgrad.
English: A phase III randomised study of Caelyx versus doxorubicin in patients with metastatic breast cancer was completed in 509 patients.
Danish: Et randomiseret fase III-forsøg af Caelyx mod doxorubucin til patienter med metastaserende brystcancer blev gennemført med 509 patienter.
English: Acute overdosing with doxorubicin hydrochloride worsens the toxic effects of mucositis, leukopaenia and thrombocytopaenia.
Danish: Akut overdosering med doxorubicinhydrochlorid forværrer de toksiske virkninger af mucositis, leukopeni og trombocytopeni.
English: In contrast, the pharmacokinetic profile of Caelyx indicates that Caelyx is confined mostly to the vascular fluid volume and that the clearance of doxorubicin from the blood is dependent upon the liposomal carrier.
Danish: I modsætning hertil indicerer den farmakokinetiske profil for Caelyx, at Caelyx fortrinsvis er begrænset til blodbanen, og at eliminationen af doxorubicin fra blodet er afhængig af liposomet som transportør.
English: Endomyocardial biopsies on nine of ten AIDS-KS patients receiving cumulative doses of Caelyx greater than 460 mg/m2 indicate no evidence of anthracycline-induced cardiomyopathy.
Danish: Endomyokardie-biopsier på ni ud af ti AIDS-KS patienter, som fik kumulative doser af Caelyx på mere end 460 mg/m2, viste ingen tegn på antracyklin-induceret kardiomyopati.
English: PPE*, alopecia, rash PPE*
Danish: PPE*, alopeci, udslæt
English: 512 patients with ovarian cancer (a subset of 876 solid tumour patients) were treated with Caelyx at a dose of 50 mg/m2 in clinical trials.
Danish: 512 patienter med ovariecancer (en gruppe på 876 solide tumorpatienter) blev behandlet med Caelyx med en dosis på 50 mg/m2 i kliniske undersøgelser.
English: Adverse drug reactions identified during the post-marketing experience with Caelyx Neoplasms benign, malignant and unspecified (incl cysts and polyps) very rare secondary oral neoplasms
Danish: Bivirkninger påvist efter markedføringen af Caelyx Benigne, maligne og uspecificerede neoplasmer (inklusive cyster og polypper) meget sjældne sekundære orale neoplasmer
English: The plasma pharmacokinetics of Caelyx were evaluated in 23 patients with KS who received single doses of 20 mg/m2 administered by a 30-minute infusion.
Danish: De farmakokinetiske forhold i plasma for Caelyx blev undersøgt hos 23 patienter med KS, der modtog engangsdoser på 20 mg/m2, indgivet som en 30 minutters infusion.
English: The pegylated liposomes also have a low permeability lipid matrix and internal aqueous buffer system that combine to keep doxorubicin hydrochloride encapsulated during liposome residence time in circulation.
Danish: De pegylerede liposomer har også en lav-permeabel lipidmatrix og et internt vandigt buffersystem, der sammen holder doxorubicinhydrochlorid indkapslet under liposomets tilstedeværelse i blodbanen.
English: Women of child-bearing potential must be advised to avoid pregnancy while they or their male partner are receiving Caelyx and in the six months following discontinuation of Caelyx therapy (see section
Danish: Fertile kvinder skal rådes til at undgå graviditet, mens de eller deres mandlige partner behandles med Caelyx samt i de første seks måneder efter seponering af Caelyx-behandling (se pkt.
English: Caelyx is used to treat cancer of the breast in patients at risk for heart problems.
Danish: Caelyx anvendes til at behandle cancer i brystet hos patienter med risiko for hjerteproblemer.
English: All Severities n=318
Danish: Alle sværhedsgrader n=318
English: There was a significant improvement in the primary endpoint of time to progression (TTP) for patients treated with combination therapy of Caelyx plus bortezomib compared to patients treated with bortezomib monotherapy as indicated by a risk reduction (RR) of 35% (95% CI: 21-47%), p < 0.0001, based on 407 TTP events.
Danish: Der var en signifikant forbedring i det primære endepunkt, tid til progression (TTP), for patienter, der blev behandlet med kombinationsbehandling med Caelyx og bortezomib, sammenlignet med patienter, der blev behandlet med bortezomib-monoterapi, indikeret ved en risikoreduktion (RR) på 35 % (95 % CI: 21-47 %), p <0,0001, baseret på 407 TTP tilfælde.
English: Caelyx must be handled and disposed of in a manner consistent with that of other anticancer medicinal products in accordance with local requirements.
Danish: Caelyx skal håndteres og bortskaffes i henhold til retningslinjerne for håndtering af andre lægemidler mod kræft i overensstemmelse med lokale krav.
English: A similar low incidence of myelosuppression was seen in patients with metastatic breast cancer receiving Caelyx in a first-line clinical trial.
Danish: En lignende lav forekomst af myelosuppression sås hos patienter med metastaserende brystcancer, som fik Caelyx i en klinisk undersøgelse med dette som førstevalgspræparat.
English: The active ingredient of Caelyx is doxorubicin hydrochloride, a cytotoxic anthracycline antibiotic obtained from Streptomyces peucetius var. caesius.
Danish: Det aktive indholdsstof i Caelyx er doxorubicinhydrochlorid, et cytotoksisk antracyklin-antibiotikum, der er udvundet af Streptomyces peucetius var. caesius.
English: Doxorubicin becomes available after the liposomes are extravasated and enter the tissue compartment.
Danish: Doxorubicin bliver tilgængeligt, efter at liposomerne har forladt karbanen og er trængt ind i vævsområderne.
English: Do not use this medicine if you notice that it shows evidence of precipitation or any other particulate matter.
Danish: Brug ikke lægemidlet, hvis du bemærker tegn på bundfældning eller anden partikeldannelse.
English: Solid tumour patients: in a larger cohort of 929 patients with solid tumours (including breast cancer and ovarian cancer) predominantly treated at a dose of 50 mg/m2 every 4 weeks, the safety profile and incidence of adverse effects are comparable to those of the patients treated in the pivotal breast cancer and ovarian cancer trials.
Danish: Solide tumorpatienter: i en større gruppe på 929 patienter med solide tumorer (inklusive brystcancer og ovariecancer) overvejende behandlet med en dosis på 50 mg/m2 hver 4. uge, er sikkerhedsprofilen og forekomsten af bivirkninger sammenlignelig med hvad der sås for patienter behandlet i de pivotale brystcancer og ovariecancer undersøgelser.
English: AIDS-related KS patients
Danish: AIDS-relateret KS-patienter
English: Haematological toxicity (ANC or platelets) - Management of patients with breast or ovarian cancer
Danish: Hæmatologisk toksicitet (neutrofile granulocytter (ANC) eller blodplader)behandling af patienter med bryst- eller ovariecancer
English: Caelyx contains less than 1 mmol sodium (23 mg) per dose, that is to say ‘essentially sodium-free'.
Danish: Caelyx indeholder mindre end 1 mmol (23 mg) natrium pr. dosis, dvs. det er i det væsentlige natriumfrit.
English: A phase III comparative study of Caelyx versus topotecan in patients with epithelial ovarian cancer following the failure of first-line, platinum-based chemotherapy was completed in 474 patients.
Danish: Et fase III-studie, der sammenlignede Caelyx mod topotecan hos patienter med epitelial ovariecancer efter svigt af førstehånds, platinbaseret kemoterapi, blev fuldført hos 474 patienter.
English: From a clinical study in patients with AIDS-KS comparing Caelyx against another treatment (bleomycin/vincristine), there may be a higher chance of some infections with Caelyx.
Danish: Ud fra en klinisk undersøgelse af patienter med AIDS-KS, hvor Caelyx er sammenlignet med en anden behandling (bleomycin/vincristin), kan der være en højere risiko for visse infektioner med Caelyx.
English: Guidelines for Caelyx dose modification
Danish: Retningslinjer for dosisjustering af Caelyx
English: 3) and extensive mucocutaneous or visceral disease.
Danish: 3) og udbredt hud-/slimhinde- eller indvoldssygdom.
English: In patients with solid tumours, including a subset of patients with breast and ovarian cancers, treated at a dose of 50 mg/m2/cycle with lifetime cumulative anthracycline doses up to 1,532 mg/m2, the incidence of clinically significant cardiac dysfunction was low.
Danish: Hos patienter med solide tumorer, omfattende en undergruppe af patienter med bryst- og ovariecancer, behandlet med en dosis på 50 mg/m2/cyklus med livstidskumulative antracyklindoser på op til 1.532 mg/m2, var hyppigheden af klinisk signifikante kardielle funktionsfejl lav.
English: In contrast, 10 of 48 doxorubicin subjects who had cardiac toxicity by LVEF criteria also developed signs and symptoms of CHF.
Danish: I modsætning hertil udviklede 10 af 48 doxorubicin patienter, som havde kardiel toksicitet ifølge LVEF kriterierne, også tegn og symptomer på hjerteinsufficiens.
English: PPE is characterised by painful, macular reddening skin eruptions.
Danish: PPE er karakteriseret ved smertefuldt, plettet rødmende hududslæt.
English: However, in clinical studies to date, dizziness and somnolence were associated infrequently (< 5%) with the administration of Caelyx.
Danish: Der er imidlertid i kliniske undersøgelser indtil dato i sjældne tilfælde (< 5 %) set svimmelhed og døsighed ved behandling med Caelyx.
English: Cardiac toxicity also may occur at cumulative anthracycline doses lower than 450 mg/m2 in patients with prior mediastinal irradiation or in those receiving concurrent cyclophosphamide therapy.
Danish: Kardiotoksicitet kan også forekomme ved kumulative antracyklindoser mindre end 450 mg/m2 hos patienter med forudgående mediastinal strålebehandling eller hos patienter i samtidig cyclophosphamidbehandling.
English: Subcutaneous tolerance studies indicate that Caelyx, as against standard doxorubicin hydrochloride, causes slighter local irritation or damage to the tissue after a possible extravasation.
Danish: Undersøgelser vedrørende subkutan tolerance tyder på, at Caelyx sammenlignet med standard doxorubicinhydrochlorid forårsager mindre lokal irritation eller skade på vævet i tilfælde af ekstravasation.
English: Very common side effects (may affect more than 1 in 10 people) - redness, swelling and sores on the palms of your hands and feet.
Danish: Meget almindelige bivirkninger (kan berøre flere end 1 ud af 10 personer) - rødmen, hævelse og sår i håndfladerne og under fødderne.
English: The table for haematological toxicity (Table 3) provides the schedule followed for dose modification in clinical trials in the treatment of patients with breast or ovarian cancer only.
Danish: Tabellen for hæmatologisk toksicitet (tabel 3) angiver fremgangsmåden, som blev fulgt for dosisjustering i kliniske undersøgelser af behandling af patienter udelukkende med bryst- eller ovariecancer.
English: Skin and subcutaneous tissue disorders common alopecia, rash uncommon palmar-plantar erythrodysesthesia (PPE) General disorders and administration site conditions common asthenia, fever, infusion-associated acute reactions
Danish: Hud og subkutane væv almindelige alopeci, udslæt ikke almindelige palmoplantar erytrodysæstesi (PPE) Almene symptomer og reaktioner på administrationsstedet almindelig asteni, feber, infusionsrelaterede akutte reaktioner
English: The following common adverse events were reported more often with doxorubicin than with Caelyx: nausea (53% vs. 37%; grade 3/4 5% vs. 3%), vomiting (31% vs. 19%; grade 3/4 4% vs. less than 1%), any alopecia (66% vs. 20%), pronounced alopecia (54% vs.7%), and neutropaenia (10% vs. 4%; grade 3/4 8% vs.
Danish: De følgende almindelige bivirkninger blev rapporteret oftere med doxorubicin end med Caelyx: kvalme (53 % mod 37 %; grad 3/4 5 % mod 3 %), opkastning (31 % mod 19 %; grad 3/4 4 % mod mindre end 1 %), enhver alopeci (66 % mod 20 %), udtalt alopeci (54 % mod 7 %) og neutropeni (10 % mod 4 %; grad 3/4 8 % mod 2 %).
English: If tolerated, the infusion may then be completed over the next hour for a total infusion time of 90 minutes.
Danish: Hvis dette tåles, kan infusionen afsluttes i løbet af den næste time med en total infusionstid på 90 minutter.
English: Stomatitis/mucositis and nausea were also commonly reported in breast/ovarian cancer patient populations, whereas the AIDS-KS Program (20 mg/m2 every 2 weeks), myelosuppression (mostly leukopaenia) was the most common side effect (see AIDS-KS).
Danish: Stomatitis/mucositis og kvalme blev ligeledes hyppigt rapporteret i bryst/ovariecancer patientpopulationer, hvorimod myelosuppression (oftest leukopeni) var den mest almindelige bivirkning i AIDS-KS-programmet (20 mg/m2 hver 2. uge) (se pkt.
English: Caelyx is also used to treat cancer of the ovary.
Danish: Caelyx anvendes også til at behandle cancer i æggestokkene.
English: Type I glass vials, each with a siliconised grey bromobutyl stopper, and an aluminium seal, with a deliverable volume of 10 ml (20 mg) or 25 ml (50 mg).
Danish: Type 1 hætteglas med en silikoneret, grå bromobutylprop og et aluminiumsforsegling, med et anvendeligt volumen på 10 ml (20 mg) eller 25 ml (50 mg).
English: PPE*, rash
Danish: PPE*, udslæt
English: Leukopaenia is the most frequent undesirable effect experienced with Caelyx in this population; neutropaenia, anaemia and thrombocytopaenia have been observed.
Danish: Leukopeni er den hyppigst forekommende bivirkning af Caelyx i denne patientgruppe; neutropeni, anæmi og trombocytopeni er blevet observeret.
English: Opportunistic infections are observed in KS patients after administration with Caelyx, and are frequently observed in patients with HIV-induced immunodeficiency.
Danish: Opportunistiske infektioner er iagttaget hos KS-patienter efter indgivelse af Caelyx og er hyppigt forekommende hos patienter med HIV-induceret immuninsufficiens.
English: Caelyx is supplied as a single pack or packs of ten vials.
Danish: Caelyx leveres som en enkeltpakning eller pakninger med 10 hætteglas.
English: Animal studies indicate that administration of doxorubicin hydrochloride as a liposomal formulation reduces the potential for extravasation injury.
Danish: Dyreforsøg tyder på, at indgift af doxorubicinhydrochlorid i form af liposomer reducerer risikoen for ekstravasationsskader.
English: Breast cancer Grades 3/4 n=254
Danish: Brystcancer Grad 3/4 n=254
English: If tolerated without reaction, the infusion rate was doubled for the next 15 minutes.
Danish: Hvis dette blev tålt uden reaktion, blev infusionshastigheden fordoblet i de følgende 15 minutter.
English: Of the 418 patients treated with Caelyx 50 mg/m2/cycle, and having a baseline measurement of left ventricular ejection fraction (LVEF) and at least one follow-up measurement assessed by MUGA scan, 88 patients had a cumulative anthracycline dose of > 400 mg/m2, an exposure level associated with an increased risk of cardiovascular toxicity with conventional doxorubicin.
Danish: Af de 418 patienter behandlet med Caelyx 50 mg/m2/cyklus, hvor baseline-målinger af LVEF og mindst én opfølgende måling blev vurderet med MUGA-scanning, havde 88 patienter en kumulativ antracyklindosis på > 400 mg/m2, et eksponeringsniveau forbundet med en forøget kardiovaskulær toksicitet med konventionel doxorubicin.
English: The plasma pharmacokinetics of Caelyx in humans differ significantly from those reported in the literature for standard doxorubicin hydrochloride preparations.
Danish: De farmakokinetiske forhold i plasma for Caelyx hos mennesker adskiller sig væsentligt fra de farmakokinetiske forhold, der i litteraturen er rapporteret for standard doxorubicinhydrochloridpræparationer.
English: Although the biological mechanism of lichenoid keratosis after doxorubicin is not known, the PRAC considers that “lichenoid keratosis” should be included as a new adverse drug reaction in section 4.8 of the SmPC based on the review of the cases.
Danish: Selvom den biologiske mekanisme bag lichenoid keratose efter doxorubicin ikke er kendt, vurderer PRAC, at "lichenoid keratose" bør inkluderes som en ny bivirkning under pkt.
English: Breast cancer program
Danish: Brystcancer-program
English: The pharmacokinetic parameters of Caelyx (primarily representing pegylated liposomal doxorubicin hydrochloride and low levels of unencapsulated doxorubicin hydrochloride) observed after the 20 mg/m2 doses are presented in
Danish: De farmakokinetiske parametre for Caelyx (primært udgørende pegyleret liposomal doxorubicinhydrochlorid og lave niveauer af uindkapslet doxorubicinhydrochlorid), målt efter doserne på 20 mg/m2 er angivet i tabel 10.
English: The median OS was 30.8 months (95% CI; 25.2-36.5 months) for the bortezomib monotherapy patients and 33.0 months (95% CI; 28.9-37.1 months) for the Caelyx plus bortezomib combination therapy patients.
Danish: Median-OS var 30,8 måneder (95 % CI: 25,2-36,5 måneder) for patienter i monoterapi med bortezomib, og 33,0 måneder (95 % CI: 28,9-37,1 måneder) for patienter i kombinationsbehandling med Caelyx plus bortezomib.
English: Psychiatric disorders uncommon confusion
Danish: Psykiske forstyrrelser ikke almindelig konfusion
English: None of the 10 Caelyx subjects who had cardiac toxicity by LVEF criteria developed signs and symptoms of CHF.
Danish: Ingen af de 10 Caelyx patienter, som havde kardiel toksicitet ifølge LVEF kriterierne, udviklede tegn og symptomer på hjerteinsufficiens.
English: To minimise the risk of infusion reactions, the initial dose is administered at a rate no greater than 1 mg/minute.
Danish: For at minimere risikoen for infusionsreaktioner indgives den første dosis med en hastighed, som ikke overstiger 1 mg/minut.
English: To minimise the risk of infusion reactions, the initial dose should be administered at a rate no greater than 1 mg/minute (see section
Danish: For at minimere risikoen for infusionsreaktioner bør den første dosis indgives med en hastighed, der ikke overstiger 1 mg/minut (se pkt.
English: Hypersensitivity to the active substance, peanut or soya, or to any of the excipients listed in section
Danish: Overfølsomhed over for det aktive stof, jordnødder eller soja eller over for et eller flere af hjælpestofferne anført i pkt.
English: Asthenia, fatigue, pyrexia
Danish: Asteni, træthed, pyreksi
English: Moreover, in a controlled clinical trial of Caelyx vs. topotecan, the incidence of treatment related sepsis was substantially less in the Caelyx-treated ovarian cancer patients as compared to the topotecan treatment group.
Danish: Ydermere, i en kontrolleret klinisk undersøgelse af Caelyx sammenlignet med topotecan var hyppigheden af behandlingsrelateret sepsis betydelig mindre i Caelyx-behandlede ovariecancerpatienter i forhold til topotecan behandlingsgruppen.
English: Partially used vials should be discarded.
Danish: Delvis brugte hætteglas skal bortkastes.
English: Pigmentation abnormal, erythema
Danish: Unormal pigmentering, erytem
English: Rare side effects (may affect up to 1 in 1,000 people) - blue colour to the skin and mucosa caused by low oxygen in the blood; - patches of skin thickening.
Danish: Sjældne bivirkninger (kan berøre op til 1 ud af 1.000 personer) - blåfarvning af hud og slimhinder forårsaget af lavt iltindhold i blodet - områder med fortykkelse af huden.
English: The cardiac safety profile for the dosing schedule recommended for both breast and ovarian cancer (50 mg/m 2) is similar to the 20 mg/m 2 profile in patients with AIDS-KS (see section 4.8).
Danish: Den kardielle sikkerhedsprofil ved den anbefalede dosering til både bryst- og ovariecancer (50 mg/m svarer til 20 mg/m2 profilen for patienter med AIDS-KS (se pkt.
English: In patients with multiple myeloma receiving Caelyx plus bortezomib, infusion-associated reactions have been reported at a rate of 3%.
Danish: Hos patienter med myelomatose, der fik Caelyx og bortezomib, har der været rapporteret infusionsassocierede reaktioner på 3 %.
English: Caelyx is a long-circulating pegylated liposomal formulation of doxorubicin hydrochloride.
Danish: Caelyx er en langtidscirkulerende pegyleret liposomal formulering af doxorubicinhydrochlorid.
English: The treatments were similar in the sub-group of patients with platinum-refractory disease: HR of 1.069 (95% CI: 0.823; 1.387), p=0.618.
Danish: Behandlingerne var sammenlignelige i undergruppen af patienter med platinrefraktær sygdom: HR på 1,069 (95 % CI: 0,823; 1,387), p=0,618.
English: Ventricular arrhythmia
Danish: Ventrikulær arytmi
English: Palmar-Plantar erythrodysesthesia Week after prior Caelyx dose
Danish: Palmoplantar erytrodysæstesi Uge efter forudgående Caelyx-dosis
English: More specific methods for the evaluation and monitoring of cardiac functions as compared to ECG are a measurement of left ventricular ejection fraction by echocardiography or preferably by Multigated
Danish: Mere specifikke metoder til evaluering og monitorering af hjertefunktion end EKG er måling af venstre ventrikels ejektionsfraktion ved ekkokardiografi eller endnu bedre ved flervejs-angiografi (MUGA).
English: For the sub-group of patients with platinum-sensitive disease the difference was greater: HR of 1.432 (95% CI: 1.066; 1.923), p=0.017.
Danish: For undergruppen af patienter med platinsensitiv sygdom var forskellen større: HR på 1,432 (95 % CI: 1,066; 1,923), p=0,017.
English: Caelyx concentrate for solution for infusion: vials which provide 10 ml (20 mg) or 25 ml (50 mg).
Danish: Caelyx koncentrat til infusionsvæske, opløsning: hætteglas indeholdende 10 ml (20 mg) eller 25 ml (50 mg).
English: Caution must be exercised when giving any other cytotoxic agents, especially myelotoxic agents, at the same time.
Danish: Forsigtighed skal udvises ved samtidig indgift af ethvert andet cytotoksisk stof og i særdeleshed ved stoffer med toksisk virkning på knoglemarven.
English: Neuropathy peripheral, neuropathy, paraesthesia, polyneuropathy, dizziness, dysgeusia
Danish: Perifer neuropati, neuropati, parestesi, polyneuropati, svimmelhed, dysgeusi
English: The recommended dose of Caelyx for AIDS-KS patients is 20 mg/m2 every two-to-three weeks.
Danish: Den anbefalede Caelyx-dosis til AIDS-KS patienter er 20 mg/m2 hver anden til tredje uge.
English: Ovarian cancer n=512
Danish: Ovariecancer n=512
English: Uncommon side effects (may affect up to 1 in 100 people) - confusion; - inflammation of the veins and formation of blood clots in the veins which could lead to blockage of blood flow to your lungs causing difficulty breathing, chest pain and palpitations; - abnormal heart rhythm, heart beat feels fast or uneven (palpitations), heart failure, which makes you short of breath and may lead to swollen legs, cardiac arrest.
Danish: Ikke almindelige bivirkninger (kan berøre op til 1 ud af 100 personer) - forvirring - betændelse i venerne og dannelse af blodpropper i venerne, hvilket kan føre til blokering af blodtilførslen til lungerne og give vejrtrækningsbesvær, brystsmerter og hjertebanken - unormal hjerterytme, hurtige og uregelmæssige hjerteslag (hjertebanken), hjertesvigt, som kan føre til stakåndethed og give hævede ben, hjertestop.