FrancophonIA/ELRC3.0 huggingface dataset:
English: The amlodipine component of Dafiro HCT inhibits the transmembrane entry of calcium ions into cardiac and vascular smooth muscle.
Slovenian: Amlodipin v zdravilu Dafiro HCT zavira transmembranski vstop kalcijevih ionov v srčne in žilne gladke mišice.
English: The use of hydrochlorothiazide may also need to be reconsidered in patients who have experienced previous NMSC (see also section 4.8).
Slovenian: Poleg tega bi bilo morda treba ponovo premisliti o uporabi hidroklorotiazida pri bolnikih, ki so že preboleli nemelanomskega kožnega raka (glejte tudi poglavje 4.8).
English: • severe skin reactions including intense skin rash, hives, reddening of the skin over your whole body, severe itching, blistering, peeling and swelling of the skin, inflammation of the mucous membranes (Stevens-Johnson syndrome, toxic epidermal necrolysis) or other allergic reactions
Slovenian: • hude kožne reakcije, vključno s hudim kožnim izpuščajem, koprivnico, pordelostjo kože po celem telesu, močnim srbenjem, pojavljanjem mehurjev, lupljenjem in otekanjem kože, vnetjem sluznic (Stevens-Johnsonov sindrom, toksična epidermalna nekroliza ) in drugimi alergijskimi reakcijami
English: In a variety of preclinical safety studies conducted in several animal species with amlodipine, valsartan, hydrochlorothiazide, valsartan/hydrochlorothiazide, amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide (Dafiro HCT), there was no evidence of systemic or target organ toxicity that would adversely affect the development of Dafiro HCT for clinical use in humans.
Slovenian: V različnih predkliničnih študijah varnosti zdravila, ki so jih izvajali na več živalskih vrstah z amlodipinom, valsartanom in hidroklorotiazidom ter s kombinacijami valsartan/hidroklorotiazid, amlodipin/valsartan in amlodipin/valsartan/hidroklorotiazid (z zdravilom Dafiro HCT), ni bilo znakov za sistemsko toksično delovanje ali toksično delovanje na tarčne organe, ki bi predstavljali razloge proti razvijanju zdravila Dafiro HCT za klinično uporabo pri ljudeh.
English: Esteve Pharmaceuticals, S.A. Tel: +34 93 446 60 00
Slovenian: Laboratorios Dr. Esteve, S.A. Tel: +34 93 446 60 00
English: • loss of pain sensation
Slovenian: • izguba občutka za bolečino
English: What Dafiro HCT is and what it is used for What you need to know before you take Dafiro HCT How to take Dafiro HCT
Slovenian: Kaj je zdravilo Dafiro HCT in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Dafiro HCT Kako jemati zdravilo Dafiro HCT Možni neželeni učinki
English: These include potassium supplements or salt substitutes containing potassium, potassium-sparing medicines and heparin;
Slovenian: Med njimi so kalijevi nadomestki ali soli, ki vsebujejo kalij, zdravila, ki varčujejo s kalijem in heparin;
English: Hypokalaemia may result in muscle spasms and or accentuate arrhythmia associated with the concomitant use of digitalis glycosides or certain anti-arrhythmic medicinal products.
Slovenian: Hipokaliemija lahko povzroči mišične krče in/ali stopnjuje srčne aritmije, ki so povezane s sočasno uporabo digitalisovih glikozidov ali določenih antiaritmičnih zdravil.
English: Clinically significant hypotension due to Dafiro HCT overdose calls for active cardiovascular support, including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulating fluid volume and urine output.
Slovenian: Klinično značilna hipotenzija zaradi prevelikega odmerka zdravila Dafiro HCT zahteva srčnožilno podporo, vključno s pogostim nadziranjem delovanja srca in dihal, dviganjem udov ter kontrolo krožečega volumna tekočine in izločanja urina.
English: In sodium-depleted and/or volume-depleted patients, such as those receiving high doses of diuretics, symptomatic hypotension may occur after initiation of treatment with Dafiro HCT.
Slovenian: Pri bolnikih s primanjkljajem natrija in/ali hipovolemijo, na primer pri bolnikih, ki prejemajo visoke odmerke diuretikov, se lahko po uvedbi zdravljenja z zdravilom Dafiro HCT pojavi simptomatska hipotenzija.
English: Furthermore, concomitant use of Dafiro HCT and NSAIDs may lead to worsening of renal function and an increase in serum potassium.
Slovenian: Poleg tega lahko sočasna uporaba zdravila Dafiro HCT in NSAIDs povzroča poslabšanje delovanja ledvic in zvišanje koncentracije kalija v serumu.
English: • increased need to urinate at night
Slovenian: • pogosto uriniranje ponoči
English: Severe renal impairment (GFR <30 ml/min/1.73 m2), anuria and patients undergoing dialysis.
Slovenian: Huda okvara ledvic (GFR <30 ml/min/1,73 m2), anurija in bolniki na dializi.
English: Based on the existing data with the components, the use of Dafiro HCT is not recommended during first trimester and contraindicated during the second and third trimester of pregnancy (see sections 4.3 and 4.4).
Slovenian: Glede na obstoječe podatke o posameznih sestavinah uporaba zdravila Dafiro HCT ni priporočljiva v prvem trimesečju nosečnosti in je kontraindicirana v drugem in tretjem trimesečju nosečnosti (glejte poglavji 4.3 in 4.4).
English: • swelling of eyelids, face or lips
Slovenian: • otekanje očesnih vek, obraza ali ustnic
English: Dafiro HCT is contraindicated in patients with hypercalcaemia and should only be used after correction of any pre-existing hypercalcaemia.
Slovenian: Zdravilo Dafiro HCT je kontraindicirano pri bolnikih s hiperkalciemijo in ga je mogoče uporabljati šele po korekciji morebitne že prisotne hiperkalciemije.
English: The use of Dafiro HCT during breastfeeding is not recommended.
Slovenian: Uporaba zdravila Dafiro HCT med dojenjem ni priporočena.
English: • inflammation of blood vessels often with skin rash
Slovenian: • vnetje krvnih žil, pogosto s kožnim izpuščajem
English: Statistically greater proportions of patients achieved blood pressure control (<140/90 mmHg) with Dafiro HCT (71%) compared to each of the three dual combination therapies (45-54%) (p<0.0001).
Slovenian: Krvni tlak je uspelo uravnati (<140/90 mmHg) statistično večjemu deležu bolnikov, ki so jemali zdravilo Dafiro HCT (71 %) v primerjavi s tistimi, ki so jemali katero od treh kombinacij s po dvema zdraviloma (45-54 %) (p<0,0001).
English: You can take Dafiro HCT with or without food.
Slovenian: Zdravilo Dafiro HCT lahko vzamete s hrano ali brez nje.
English: Non-steroidal antiinflammatory drugs (NSAIDs), including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors), acetylsalicylic acid (>3 g/day), and nonselective NSAIDs
Slovenian: valsartan in hidroklorotiazid nesteroidna protivnetna zdravila (NSAIDs), vključno s selektivnimi zaviralci ciklooksigenaze-2 (z zaviralci COX-2), acetilsalicilno kislino (>3 g/dan) in neselektivnimi NSAIDs
English: The half-life of amlodipine is prolonged and AUC values are higher in patients with impaired liver function; dose recommendations have not been established.
Slovenian: Pri bolnikih z okvaro jeter je razpolovni čas amlodipina podaljšan, vrednosti AUC pa so višje; priporočila za prilagoditev odmerkov niso bila izoblikovana.
English: Dafiro HCT can be used by people aged 65 years and over at the same dose as for other adults and in the same way as they have already taken the three substances called amlodipine, valsartan and hydrochlorothiazide.
Slovenian: Ljudje, ki so stari 65 let ali več, lahko uporabljajo zdravilo Dafiro HCT v enakih odmerkih kot drugi odrasli in na povsem enak način, kot so prej jemali tri učinkovine amlodipin, valsartan in hidroklorotiazid.
English: The full blood pressure lowering effect was achieved 2 weeks after being on their maximal dose of Dafiro HCT.
Slovenian: Do polnega učinka na zniževanje krvnega tlaka je prišlo po 2 tednih zdravljenja z najvišjimi odmerki zdravila Dafiro HCT.
English: Elderly patients, particularly those taking the maximum dose of Dafiro HCT (10 mg/320 mg/25 mg), should have their blood pressure checked regularly.
Slovenian: Starejšim bolnikom, zlasti tistim, ki uporabljajo najvišji odmerek zdravila Dafiro HCT (10 mg/320 mg/25 mg), je treba redno meriti krvni tlak.
English: Other: dual blockade of the renin-angiotensin-aldosterone system (RAAS)
Slovenian: Drugo: Dvojno zaviranje sistema renin-angiotenzin-aldosteron (RAAS)
English: Obstruction of the outflow tract of the left ventricle (e.g. hypertrophic obstructive cardiomyopathy and high grade aortic stenosis).
Slovenian: Zapora pretoka krvi iz levega prekata (npr. hipertrofična obstruktivna kardiomiopatija in močno izražena aortna stenoza).
English: Non-melanoma skin cancer: based on available data from epidemiological studies, cumulative dose-dependent association between hydrochlorothiazide and NMSC has been observed (see also sections 4.4 and 5.1).
Slovenian: Nemelanomski kožni rak: Na podlagi obstoječih podatkov epidemioloških študij so ugotovili, da obstaja razmerje med kumulativnim odmerkom hidroklorotiazida in nemelanomskim kožnim rakom (glejte tudi poglavji 4.4 in 5.1).
English: • sudden wheeziness, chest pain, shortness of breath or difficulty breathing
Slovenian: • nenadno piskajoče dihanje, bolečine v prsih, kratka sapa ali težave z dihanjem
English: This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active substance amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of Dafiro HCT.
Slovenian: Grenivka in grenivkin sok lahko namreč povzročita zvišanje koncentracije učinkovine amlodipina v krvi, kar lahko pripelje do nepredvidljivega povečanja učinka zdravila Dafiro HCT pri zniževanju krvnega tlaka.
English: If excessive hypotension occurs with Dafiro HCT, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline.
Slovenian: Če se med uporabo zdravila Dafiro HCT pojavi čezmerna hipotenzija, je treba bolnika poleči in mu, če je potrebno, dati intravensko infuzijo fiziološke raztopine.
English: The safety of Dafiro HCT has been evaluated at its maximum dose of 10 mg/320 mg/25 mg in one controlled short-term (8 weeks) clinical study with 2,271 patients, 582 of whom received valsartan in combination with amlodipine and hydrochlorothiazide.
Slovenian: Varnost zdravila Dafiro HCT so ocenjevali pri uporabi njegovega najvišjega odmerka 10 mg/320 mg/25 mg, in sicer v eni kotrolirani kratkotrajni (8-tedenski) klinični študiji z 2.271 bolniki, od katerih jih je 582 prejemalo valsartan v kombinaciji z amlodipinom in s hidroklorotiazidom.
English: High hydrochlorothiazide use (≥50000 mg cumulative) was associated with an adjusted odds ratio (OR) of 1.29 (95% CI: 1.23-1.35) for BCC and 3.98 (95% CI: 3.68-4.31) for SCC.
Slovenian: Veliki odmerki hidroklorotiazida (kumulativno ≥ 50.000 mg) so bili povezani s prilagojenim razmerjem obetov (odds ratio (OR)) 1,29 (95-odstotni IZ: 1,23-1,35) za bazalnocelični karcinom in 3,98 (95-odstotni IZ: 3,68-4,31) za ploščatocelični karcinom.
English: What you need to know before you take Dafiro HCT
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Dafiro HCT
English: Non-melanoma skin cancer (Basal cell carcinoma and Squamous cell carcinoma)
Slovenian: nemelanomski kožni rak (bazalnocelični karcinom in ploščatocelični karcinom)
English: The safety profile of Dafiro HCT presented below is based on clinical studies performed with Dafiro HCT and the known safety profile of the individual components amlodipine, valsartan and hydrochlorothiazide.
Slovenian: Spodaj navedene varnostne lastnosti zdravila Dafiro HCT se nanašajo na podatke iz študij z zdravilom Dafiro HCT in na znane varnostne lastnosti njegovih posameznih sestavin amlodipina, valsartana in hidroklorotiazida.
English: There is evidence that the concomitant use of ACE inhibitors, ARBs or aliskiren increases the risk of hypotension, hyperkalaemia, and decreased renal function (including acute renal failure).
Slovenian: Obstajajo dokazi, da sočasna uporaba zaviralcev ACE, antagonistov angiotenzinskih receptorjev ali aliskirena poveča tveganje za hipotenzijo, hiperkaliemijo in zmanjšano delovanje ledvic (vključno z akutno odpovedjo ledvic).
English: Frequency Dafiro HCT
Slovenian: Pogostnost Dafiro HCT
English: Dual blockage of RAAS through the combined use of ACE inhibitors, ARBs or aliskiren is therefore not recommended (see sections 4.5 and 5.1).
Slovenian: Dvojna blokada sistema RAAS s hkratno uporabo zaviralcev ACE, antagonistov angiotenzinskih receptorjev ali aliskirena zato ni priporočljiva (glejte poglavji 4.5 in 5.1).
English: When switching eligible elderly hypertensive patients (see section 4.1) to Dafiro HCT, the lowest available dose of the amlodipine component should be used.
Slovenian: Pri prehodu ustreznih starejših bolnikov s hipertezijo (glejte poglavje 4.1) na zdravilo Dafiro HCT, je potrebno uporabiti najnižji razpoložljivi odmerek amlodipina.
English: Dafiro HCT combines three antihypertensive compounds with complementary mechanisms to control blood pressure in patients with essential hypertension: amlodipine belongs to the calcium antagonist class and valsartan to the angiotensin II antagonist class of medicines and hydrochlorothiazide belongs to the thiazide diuretics class of medicines.
Slovenian: Zdravilo Dafiro HCT vsebuje tri antihipertenzivne učinkovine s komplementarnimi mehanizmi delovanja za obvladanje krvnega tlaka pri bolnikih z esencialno hipertenzijo: amlodipin spada med zaviralce kalcijevih kanalčkov, valsartan med antagoniste angiotenzina II in hidroklorotiazid v skupino tiazidnih diuretikov.
English: If photosensitivity reaction occurs during treatment with Dafiro HCT, it is recommended to stop the treatment.
Slovenian: Če med zdravljenjem z zdravilom Dafiro HCT pride do fotosenzitivnostne reakcije, je priporočena prekinitev zdravljenja.
English: The side effects reported with Dafiro HCT or one of its three active substances (amlodipine, valsartan and hydrochlorothiazide) are listed below and may occur with the use of Dafiro HCT.
Slovenian: Neželeni učinki, o katerih so poročali pri uporabi zdravila Dafiro HCT ali pri uporabi katere od treh učinkovin (amlodipina, valsartana in hidroklorotiazida), so navedeni spodaj in se lahko pojavijo pri uporabi zdravila Dafiro HCT.
English: Due to the hydrochlorothiazide component, Dafiro HCT is contraindicated for use in patients with anuria (see section 4.3) and in patients with severe renal impairment (glomerular filtration rate (GFR) <30 ml/min/1.73 m2) (see sections 4.3, 4.4 and 5.2).
Slovenian: Zaradi vsebnosti hidroklorotiazida je zdravilo Dafiro HCT kontraindicirano za uporabo pri bolnikih z anurijo (glejte poglavje 4.3) in pri bolnikih s hudo okvaro ledvic (s hitrostjo glomerulne filtracije (GFR) <30 ml/min/1,73 m2) (glejte poglavja 4.3, 4.4 in 5.2).
English: Since renal clearance of lithium is reduced by thiazides, the risk of lithium toxicity may presumably be increased further with Dafiro HCT.
Slovenian: Ker tiazidi zmanjšajo ledvični očistek litija, uporaba zdravila Dafiro HCT lahko predvidoma poveča toksične učinke litija.
English: • medicines that may induce “torsades de pointes” (irregular heart beat), such as antiarrhythmics
Slovenian: • zdravil, ki lahko sprožijo “torsades de pointes” (nepravilen srčni ritem), kot so antiaritmiki (zdravila za zdravljenje težav s srcem) in nekateri antipsihotiki;
English: In the 8-week controlled clinical study, changes in laboratory parameters observed with the combination of Dafiro HCT were minor and consistent with the pharmacological mechanism of action of the monotherapy agents.
Slovenian: V 8-tedenski kontrolirani klinični študiji so bile pri uporabi kombinacije v zdravilu Dafiro HCT spremembe vrednosti laboratorijskih parametrov majhne in v skladu s farmakološkim načinom delovanja posameznih sestavin.
English: The rate and extent of absorption of amlodipine, valsartan and hydrochlorothiazide from Dafiro HCT are the same as when administered as individual dosage forms.
Slovenian: Hitrosti in obsegi absorpcije amlodipina, valsartana in hidroklorotiazida se ne razlikujejo od tistih pri odmerjanju posameznih sestavin.
English: After oral administration of therapeutic doses of amlodipine alone, peak plasma concentrations of amlodipine are reached in 6-12 hours.
Slovenian: Po peroralni uporabi terapevtskih odmerkov samega amlodipina ta doseže največjo koncentracijo v plazmi v 6 do 12 urah.
English: When switching eligible hypertensive patients (see section 4.1) with hepatic impairment to Dafiro HCT, the lowest available dose of the amlodipine component should be used.
Slovenian: Pri prehodu ustreznih bolnikov s hipertezijo (glejte poglavje 4.1) z jetrno okvaro na zdravilo Dafiro HCT, je potrebno uporabiti najnižji razpoložljivi odmerek amlodipina.
English: 56 x 1 film-coated tablet (unit dose) 98 x 1 film-coated tablet (unit dose) 280 x 1 film-coated tablet (unit dose)
Slovenian: 56 x 1 filmsko obložena tableta (za enkratni odmerek) 98 x 1 filmsko obložena tableta (za enkratni odmerek) 280 x 1 filmsko obložena tableta (za enkratni odmerek)
English: Dafiro HCT is used to treat high blood pressure in adult patients whose blood pressure is already controlled while taking amlodipine, valsartan and hydrochlorothiazide and who may benefit from taking one tablet containing all three substances.
Slovenian: Zdravilo Dafiro HCT uporabljamo za zdravljenje visokega krvnega tlaka pri odraslih bolnikih, pri katerih je krvni tlak že urejen, kadar jemljejo amlodipin, valsartan in hidroklorotiazid in bi jim ustrezalo jemanje ene same tablete, ki vsebuje vse tri učinkovine.
English: • low level of blood platelets (sometimes with bleeding or bruising underneath the skin)
Slovenian: • znižano število trombocitov (včasih s krvavitvami ali podplutbami)
English: Therefore, Dafiro HCT is not recommended in this population.
Slovenian: Iz tega razloga uporaba zdravila Dafiro HCT ni priporočena pri tej skupini bolnikov.
English: Name and address of the manufacturer responsible for batch release
Slovenian: Ime in naslov izdelovalca, odgovornega za sproščanje serij Novartis Farmacéutica SA
English: If Dafiro HCT is used during breast-feeding, doses should be kept as low as possible.
Slovenian: Če bolnica uporablja zdravilo Dafiro HCT v času dojenja, naj uporablja čim nižje odmerke.
English: Possible preventive measures such as limited exposure to sunlight and UV rays and, in case of exposure, adequate protection should be advised to the patients in order to minimise the risk of skin cancer.
Slovenian: Možna preventivna ukrepa za zmanjševanje tveganja za nastanek kožnega raka, ki naj se svetujeta bolnikom, sta zmanjšanje izpostavljenosti sončni svetlobi in UV-žarkom ter uporaba ustrezne zaščite v primeru izpostavljenosti.
English: Not known Rare
Slovenian: pogostnost neznana
English: Following oral administration of valsartan alone, peak plasma concentrations of valsartan are reached in 2-4 hours.
Slovenian: Po peroralni uporabi samega valsartana ta doseže največjo koncentracijo v plazmi v 2 do 4 urah.
English: If hypokalaemia develops during hydrochlorothiazide therapy, Dafiro HCT should be discontinued until stable correction of the potassium balance.
Slovenian: Če se hipokaliemija pojavi v času zdravljenja s hidroklorotiazidom, je treba uporabo zdravila Dafiro HCT prekiniti, dokler ni ravnovesje kalija stabilno.
English: • discomfort or enlargement of the breasts in men
Slovenian: • neprijeten občutek v dojkah ali čezmerna rast tkiva v dojkah pri moških
English: In the controlled trial of Dafiro HCT, the counteracting effects of valsartan 320 mg and hydrochlorothiazide 25 mg on serum potassium approximately balanced each other in many patients.
Slovenian: V kontroliranem preskušanju zdravila Dafiro HCT sta bila pri številnih bolnikih nasprotna učinka valsartana 320 mg in hidroklorotiazida 25 mg na koncentracijo kalija v serumu približno v ravnovesju.
English: No formal interaction studies with other medicinal products have been performed with Dafiro HCT.
Slovenian: Formalnih študij medsebojnega delovanja zdravila Dafiro HCT z drugimi zdravili niso izvedli.
English: Heart failure and coronary artery disease/post-myocardial infarction
Slovenian: Srčno popuščanje in koronarna bolezen/obdobje po miokardnem infarktu
English: Sodium- and/or volume-depleted patients
Slovenian: Bolniki s primanjkljajem natrija in/ali volumna telesnih tekočin
English: • yellowing of the skin (jaundice)
Slovenian: • porumenelost kože (zlatenica)
English: 5.2 Pharmacokinetic properties
Slovenian: 5.2 Farmakokinetične lastnosti Linearnost
English: Hydrochlorothiazide is eliminated from plasma with a half-life averaging 6 to 15 hours in the terminal elimination phase.
Slovenian: V terminalni fazi izločanja se hidroklorotiazid iz plazme izloča z razpolovnim časom povprečno 6 do 15 ur.
English: • liver disorders which can occur together with yellow skin and eyes, or dark-coloured urine
Slovenian: • bolezni jeter, ki jih lahko spremljajo rumena koža in oči ali temno obarvan urin (hemolitična anemija)
English: • inflammation of the liver (hepatitis)
Slovenian: • vnetje jeter (hepatitis)
English: Amlodipine is excreted in human milk.
Slovenian: Amlodipin se izloča v materino mleko.
English: The maximum recommended dose of Dafiro HCT is 10 mg/320 mg/25 mg.
Slovenian: Najvišji priporočeni odmerek zdravila Dafiro HCT je 10 mg/320 mg/25 mg.
English: Following oral administration of Dafiro HCT in normal healthy adults, peak plasma concentrations of amlodipine, valsartan and hydrochlorothiazide are reached in 6-8 hours, 3 hours, and 2 hours, respectively.
Slovenian: Po peroralni uporabi zdravila Dafiro HCT pri normalnih zdravih odraslih doseže amlodipin najvišjo koncentracijo v plazmi v 6-8 urah, valsartan v 3 urah, hidroklorotiazid pa v 2 urah.
English: Therefore careful monitoring of serum lithium concentrations is recommended during concomitant use.
Slovenian: Med sočasno uporabo je zato priporočljivo natančno kontrolirati koncentracijo litija v serumu.
English: Other medicines and Dafiro HCT
Slovenian: Druga zdravila in zdravilo Dafiro HCT
English: There are no clinical studies on fertility with Dafiro HCT.
Slovenian: Kliničnih študij glede plodnosti pri uporabi zdravila Dafiro HCT ni.
English: Dafiro HCT tablets contain three substances called amlodipine, valsartan and hydrochlorothiazide.
Slovenian: Tablete Dafiro HCT vsebujejo tri učinkovine: amlodipin, valsartan in hidroklorotiazid.
English: This medicine may make you feel dizzy, drowsy, nauseous or have a headache.
Slovenian: Vpliv na sposobnost upravljanja vozil in strojev Zaradi tega zdravila lahko postanete omotični oziroma zaspani, lahko vam postane slabo ali vas boli glava.
English: If a medicinal product that affects potassium levels is considered necessary in combination with valsartan, frequent monitoring of potassium plasma levels is advised.
Slovenian: Če kaže, da je treba v kombinaciji z valsartanom nujno uporabljati zdravilo, ki vpliva na koncentracijo kalija, je priporočljivo pogosto kontrolirati koncentracijo kalija v plazmi.
English: When Dafiro HCT is used in patients with renal impairment periodic monitoring of serum electrolytes (including potassium), creatinine and uric acid serum levels is recommended.
Slovenian: Pri bolnikih z okvaro ledvic, ki jemljejo zdravilo Dafiro HCT, je priporočljivo periodično kontrolirati koncentracije elektrolitov v serumu (vključno s koncentracijami kalija), kreatinina in sečne kisline.
English: If you get these symptoms, stop taking Dafiro HCT and contact your doctor straight away.
Slovenian: Če opazite navedene simptome, takoj prenehajte jemati zdravilo Dafiro HCT in obvestite svojega zdravnika.
English: • medicines that may reduce the amount of sodium in your blood, such as antidepressants,
Slovenian: • zdravil, ki lahko znižajo količino natrija v krvi, kot so antidepresivi, antipsihotiki in antiepileptiki;
English: Thiazides, including hydrochlorothiazide, may reduce the renal excretion of cytotoxic agents (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Slovenian: Citotoksične učinkovine Tiazidi, vključno s hidroklorotiazidom, lahko zmanjšajo izločanje citotoksičnih učinkovin (npr. ciklofosfamida in metotreksata) preko ledvic in stopnjujejo njihov mielosupresiven učinek.