FrancophonIA/ELRC3.0 huggingface dataset:
English: During the one year of treatment with Ribavirin in combination with interferon alfa-2b, some children and adolescents did not grow or gain weight as much as expected.
Croatian: Tijekom godine dana liječenja lijekom Ribavirin Mylan u kombinaciji s interferonom alfa-2b, neka djeca i adolescenti nisu narasli niti dobili na težini koliko se očekivalo.
English: Interferon alfa-2b (pegylated and non-pegylated) therapy may be initiated if TSH levels can be maintained in the normal range by medication.
Croatian: Terapija interferonom alfa-2b (pegiliranim ili nepegiliranim) može se započeti ako se razina TSH-a lijekovima može održavati u rasponu normalnih vrijednosti.
English: Due to substantial increases in ribavirin plasma concentrations in patients with moderate and severe renal impairment, Ribavirin Mylan dose adjustments are recommended in adult patients with creatinine clearance < 50 mL/minute.
Croatian: Zbog značajnih povećanja u koncentracijama ribavirina u plazmi u bolesnika s umjerenim i ozbiljnim oštećenjem bubrega, prilagodbe doze lijeka Ribavirin Mylan preporučuju se u odraslih bolesnika s klirensom kreatinina < 50 ml/min.
English: If week 12 HCV-RNA is positive and decreased ≥ 2 log10 from baseline, then retest HCV-RNA at week 24 and if positive, patients to stop therapy.
Croatian: Ako je u 12. tjednu HCV-RNK pozitivna i smanjena za ≥ 2 log10 od početne vrijednosti, HCV-RNK se ponovno određuje u 24. tjednu i ako je pozitivna, bolesniku se prekida liječenje.
English: Talk to your doctor or pharmacist before taking Ribavirin Mylan.
Croatian: Obratite se svom liječniku prije nego uzmete Ribavirin Mylan.
English: Table 2 provides guidelines for dose modifications and discontinuation based on the patient's haemoglobin concentration, cardiac status and indirect bilirubin concentration.
Croatian: U Tablici 2 navedene su smjernice za izmjenu doze i prekid doziranja na temelju koncentracije hemoglobina, srčanog statusa i koncentracije indirektnog bilirubina u bolesnika.
English: Previously untreated patients:
Croatian: Bolesnici koji prethodno nisu liječeni:
English: The combination of Ribavirin Mylan and other medicines is used to treat adult patients who have chronic hepatitis C (HCV).
Croatian: Kombinacija lijeka Ribavirin Mylan i drugih lijekova primjenjuje se za liječenje odraslih bolesnika koji imaju kronični hepatitis C (HCV).
English: The Kaplan-Meier estimate for continued sustained response over 5 years is 98 % [95 % CI: 95 %, 100 %] for paediatric patients treated with interferon alfa-2b and ribavirin.
Croatian: Kaplan-Meierova procjena održivosti trajnog odgovora tijekom 5 godina iznosi 98 % [95 % CI: 95 %, 100 %] za pedijatrijske bolesnike liječene interferonom alfa-2b i ribavirinom.
English: Table 3 provides guidelines for discontinuation based on the patient's indirect bilirubin concentration.
Croatian: Tablici 3 navedene su smjernice za prekid doziranja na temelju koncentracija indirektnog bilirubina u bolesnika.
English: The following side effects have been reported with the combination of this medicine and an alpha interferon product in adults:
Croatian: Sljedeće su nuspojave prijavljene kod primjene kombinacije ovog lijeka i alfa interferona u odraslih:
English: Patients who are treated with interferon alfa-2b and ribavirin after previous relapse from interferon therapy or who are treated for a shorter period are likely to have an improved safety profile than that described below.
Croatian: U bolesnika koji se liječe interferonom alfa-2b i ribavirinom zbog relapsa nakon prethodne terapije interferonom te u onih koji su liječeni u kraćem periodu veća je vjerojatnost da će imati bolji sigurnosni profil nego što je opisano u nastavku.
English: Adult: ≥ 12g/dL (females); ≥ 13g/dL (males) Children and adolescents: ≥ 11g/dL (females); ≥ 12g/dL (males)
Croatian: Odrasli: ≥ 12 g/dl (žene); ≥ 13 g/dl (muškarci)
English: White opaque body imprinted "riba/200" in green and a white opaque cap imprinted "riba/200" in green.
Croatian: Bijelo neprozirno tijelo kapsule sa zelenim natpisom „riba/200” i bijela neprozirna kapica sa zelenim natpisom „riba/200”.
English: Pancytopenia: Ribavirin Mylan can cause a decrease in your platelet and red and white blood cell count when used in combination with peginterferon.
Croatian: Pancitopenija: Ribavirin Mylan može prouzročiti smanjenje broja trombocita te crvenih i bijelih krvnih zrnaca kad se primjenjuje u kombinaciji s peginterferonom.
English: Therefore, there is a minimal potential for P450 enzyme-based interactions.
Croatian: Stoga je potencijal razvoja interakcija vezanih uz enzim citokrom P450 minimalan.
English: Blisters: Cardboard box containing 56 or 168 hard capsules in PVC/Aclar - Aluminium foil blisters
Croatian: Blisteri: Kartonska kutija s 56 ili 168 tvrdih kapsula u blisterima od PVC/Aclar-aluminijske folije,
English: The 6 month treatment duration in this trial was better tolerated than one year of treatment in the pivotal combination trial; for discontinuation 5 % vs. 14 %, for dose modification 18 % vs. 49 %.
Croatian: Šestomjesečno liječenje u ovom ispitivanju podnosilo se bolje nego jednogodišnje liječenje u pivotalnom ispitivanju kombinirane terapije; prekid liječenja zabilježen je u 5 % u odnosu na 14 % bolesnika, a prilagodba doze u 18 % u odnosu na 49 % bolesnika.
English: The sustained response at the end of follow-up was significantly increased by the addition of ribavirin capsules to interferon alfa-2b (41% vs 16%, p < 0.001).
Croatian: Trajni odgovor na kraju perioda praćenja značajno se povećao dodavanjem kapsula lijeka Ribavirin Mylan interferonu alfa-2b (41 % u odnosu na 16 %, p < 0,001).
English: Injury, poisoning and procedural complications Common:
Croatian: pozitivna antitiroidna protutijela Ozljede, trovanja i proceduralne komplikacije često:
English: Ribavirin Mylan therapy must not be initiated until a report of a negative pregnancy test has been obtained immediately prior to initiation of therapy.
Croatian: Liječenje lijekom Ribavirin Mylan ne smije se započeti dok se ne dobije negativan rezultat testa na trudnoću neposredno prije početka terapije.
English: Within the organ system classes, adverse reactions are listed under headings of frequency using the following categories: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000); not known.
Croatian: Nuspojave su razvrstane prema organskim sustavima i kategorijama učestalosti definiranima na sljedeći način: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000), nepoznato.
English: Haemoglobin concentrations should be monitored closely during treatment and corrective action taken as necessary (see section 4.2).
Croatian: Tijekom liječenja treba pažljivo nadgledati koncentracije hemoglobina te poduzeti korektivna djelovanja prema potrebi (vidjeti dio 4.2).
English: p Value a
Croatian: p vrijednost a
English: There were some cases of more severe neutropenia in patients treated with ribavirin capsules in combination with peginterferon alfa-2b (WHO grade 3: 39 of 186 [21%]; and WHO grade 4: 13 of 186 [7%]); WHO grade 3 leukopenia was also reported in 7% of this treatment group.
Croatian: Bilo je slučajeva teže neutropenije u bolesnika liječenih kapsulama ribavirina u kombinaciji s peginterferonom alfa-2b (stupanj 3 SZO: 39 od 186 [21 %] bolesnika; i stupanj 4 SZO: 13 od 186 bolesnika [7 %]); leukopenija stupnja 3 SZO također je zabilježena u 7% bolesnika u ovoj terapijskoj skupini.
English: Ribavirin does not inhibit cytochrome P450 enzymes.
Croatian: Ribavirin Mylan ne inhibira enzime citokroma P450.
English: The haemolytic anaemia associated with ribavirin therapy may result in deterioration of cardiac function and/or worsening of pre-existing cardiac disease.
Croatian: Hemolitička anemija povezana s terapijom ribavirinom može rezultirati pogoršanjem srčane funkcije i/ili pogoršanjem već postojeće bolesti srca.
English: - chest pain or persistent cough; changes in the way your heart beats, fainting, - confusion, feeling depressed; suicidal thoughts or aggressive behaviour, attempt suicide,
Croatian: - bol u prsima ili uporan kašalj; promjene načina otkucaja srca, nesvjestica, - smetenost, depresivnost; razmišljanje o samoubojstvu ili agresivno ponašanje, pokušaj,
English: Patients whose dose of Ribavirin Mylan is reduced to 600 mg daily receive one 200 mg capsule in the morning and two 200 mg capsules in the evening.
Croatian: Bolesnici kojima je doza lijeka Ribavirin Mylan smanjena na dnevnu dozu od 600 mg uzimaju jednu kapsulu od 200 mg ujutro i dvije kapsule od 200 mg navečer.
English: * For patients receiving a 1,000 mg (< 75 kg) or 1,200 mg (> 75 kg) dose, ribavirin dose should be reduced to 600 mg/day (administered as one 200 mg capsule in the morning and two 200 mg capsules in the evening).
Croatian: * Za bolesnike koji primaju dozu od 1 000 mg (< 75 kg) ili 1 200 mg (> 75 kg), dozu ribavirina treba smanjiti na 600 mg/dan (primijenjeno kao jedna kapsula od 200 mg ujutro i dvije kapsule od 200 mg uvečer).
English: Genotype 1/4 59.7 (129/216)
Croatian: Genotip 1/4 59,7 (129/216) 51,2 (66/129)
English: Decrease in mean height percentile at year 1 of long-term follow-up was most prominent in prepubertal age children.
Croatian: Srednja vrijednost smanjenja na percentilnoj krivulji rasta nakon godinu dana dugotrajnog praćenja bila je najizraženija u djece pretpubertetske dobi.
English: Overall, approximately 36% (821/2,286) of patients had undetectable plasma HCV-RNA levels at week 12 of therapy measured using a research-based test (limit of detection 125 IU/ml).
Croatian: Sveukupno je razina HCV-RNK u plazmi bila nemjerljiva u oko 36 % (821/2286) bolesnika u 12. tjednu liječenja, mjereno pomoću testa utemeljenog na istraživanju (granica detekcije 125 IU/ml).
English: Not Known:
Croatian: nepoznato:
English: Tabulated list of adverse reactions for adults
Croatian: Tablični popis nuspojava za odrasle
English: Thirty two percent (30/94) of subjects demonstrated > 15 percentile decrease in height-for-age percentile 5 years after completion of therapy (see sections 4.8 and 5.1).
Croatian: Trideset i dva posto ispitanika (30/94) pokazalo je smanjenje od > 15 percentila na percentilnoj krivulji rasta za određenu dob 5 godina nakon završetka terapije (vidjeti dijelove 4.8 i 5.1)
English: No data are available regarding dose modification for paediatric patients with renal impairment (see sections 4.2 and 5.2).
Croatian: Nisu dostupni podaci u pogledu izmjene doze za pedijatrijske bolesnike s oštećenom funkcijom bubrega (vidjeti dio 4.2 i 5.2).
English: Not known side effects (frequency cannot be estimated from the available data): thoughts about threatening the life of others, mania (excessive or unreasonable enthusiasm), pericarditis (inflammation of the lining of the heart), pericardial effusion [a fluid collection that develops between the pericardium (the lining of the heart) and the heart itself, change in colour of the tongue.
Croatian: Nepoznate nuspojave (učestalost se ne može procijeniti iz dostupnih podataka): misli o ugrožavanju života drugih, manija (pretjerano ili bezrazložno ushićenje), perikarditis (upala srčane ovojnice), perikardijalni izljev (nakupljanje tekućine između srčane ovojnice i samog srca), promjena boje jezika.
English: Each Ribavirin Mylan hard capsule contains a small amount of lactose.
Croatian: Svaka Ribavirin Mylan kapsula sadrži malu količinu laktoze.
English: Table 4 provides guidelines for dose modification for patients with renal dysfunction.
Croatian: U tablici 4 navedene su smjernice za izmjenu doze za bolesnike s disfunkcijom bubrega.
English: In those patients that received >10.6 mg/kg ribavirin (800 mg dose in typical 75 kg patient), regardless of genotype or viral load, response rates were significantly higher than in those patients that received ≤ 10.6 mg/kg Ribavirin (Table 7), while response rates in patients that received > 13.2 mg/kg ribavirin were even higher.
Croatian: U bolesnika koji su primali > 10,6 mg/kg ribavirina (doza od 800 mg u bolesnika tjelesne težine 75 kg), bez obzira na genotip ili virusno opterećenje, stope odgovora su bile značajno više nego u onih koji su primali ≤ 10,6 mg/kg ribavirina (Tablica 7), dok je stopa odgovora u bolesnika koji su primali > 13,2 mg/kg ribavirina bila još i viša.
English: Forty-one percent of subjects (97/235) had nondetectable plasma HCV-RNA levels at week 4 and week 24 of therapy.
Croatian: Od ukupnog broja bolesnika njih 41 % (97/235) je imalo nemjerljive razine HCV-RNK u plazmi u 4. i 24. tjednu terapije.
English: • Genotypes Non-1: The decision to extend therapy to one year in patients with negative HCVRNA after six months of treatment should be based on other prognostic factors (e.g., age > 40 years, male gender, bridging fibrosis).
Croatian: • Ostali genotipovi koji nisu genotip 1: Odluku o produljenju liječenja na godinu dana u bolesnika s negativnim nalazom HCV-RNK nakon šest mjeseci liječenja se mora donijeti na temelju drugih prognostičkih faktora (npr. dob > 40 godina, muški spol, premoštavajuća fibroza).
English: Extreme care must be taken to avoid pregnancy in partners of male patients taking Ribavirin Mylan (see sections 4.3, 4.4 and 5.3).
Croatian: Mora se strogo paziti da se izbjegne trudnoća u žena čiji partneri uzimaju Ribavirin Mylan (vidjeti dijelove 4.3, 4.4 i 5.3).
English: Unit Dose Blisters:
Croatian: Blisteri djeljivi na jedinične doze:
English: GSP Proizvodi d.o.o Tel: +386 1 236 31 85
Croatian: GSP Proizvodi d.o.o Tél: +386 1 236 31 85
English: Previously treatment failure patients
Croatian: Prethodno neuspješno liječeni bolesnici
English: Co-administration of Ribavirin Mylan and didanosine is not recommended.
Croatian: Ne preporučuje se istodobna primjena lijeka Ribavirin Mylan i didanozina.
English: Ribavirin, by having an inhibitory effect on inosine monophosphate dehydrogenase, may interfere with azathioprine metabolism possibly leading to an accumulation of 6-methylthioinosine monophosphate (6-MTIMP), which has been associated with myelotoxicity in patients treated with azathioprine.
Croatian: Ribavirin Mylan svojim inhibicijskim učinkom na inozin monofosfat dehidrogenazu može interferirati s metabolizmom azatioprina, što može dovesti do nakupljanja 6-metiltioinozin monofosfata (6-MTIMP), što se u bolesnika liječenih azatioprinom povezuje s mijelotoksičnošću.
English: Table 12 Rates of Response to retreatment in prior treatment failures
Croatian: Tablica 12 Stope odgovora na ponovljeno liječenje nakon neuspjeha prethodnog liječenja
English: In clinical trials of 118 children and adolescents 3 to 16 years of age treated with combination therapy of interferon alfa-2b and ribavirin, 6% discontinued therapy due to adverse reactions.
Croatian: U kliničkim ispitivanjima sa 118 djece i adolescenata u dobi od 3 do 16 godina koji su liječeni kombiniranom terapijom interferona alfa-2b i ribavirina, 6 % bolesnika prekinulo je terapiju zbog nuspojava.
English: c: Patients with genotype 3 low viral load (< 600,000 IU/ml) were to receive 24 weeks of treatment while those with genotype 3 and high viral load (≥ 600,000 IU/ml) were to receive 48 weeks of treatment.
Croatian: c: Bolesnici s genotipom 3 i malim virusnim opterećenjem (<600 000 IU/ml) liječeni su 24 tjedna, a bolesnici s genotipom 3 i velikim virusnim opterećenjem (≥600 000 IU/ml) liječeni su 48 tjedana.
English: The Ribavirin Mylan hard capsule is available in different pack sizes:
Croatian: Tvrda kapsula lijeka Ribavirin Mylan dostupna je u više različitih pakovanja:
English: Other medicines and Ribavirin Mylan
Croatian: Drugi lijekovi i Ribavirin Mylan
English: Prior to initiation of interferon alfa-2b therapy, TSH levels must be evaluated and any thyroid abnormality detected at that time must be treated with conventional therapy.
Croatian: Prije početka liječenja interferonom alfa-2b mora se odrediti razina TSH-a, a svaki poremećaj funkcije štitnjače koji se tada otkrije mora se liječiti standardnom terapijom.
English: Caucasian patients had a higher sustained virologic response rate compared to the African Americans.
Croatian: U bolesnika bijele rase stopa trajnog virološkog odgovora bila je viša nego u afroameričkih bolesnika.
English: Haemolysis: Ribavirin Mylan can cause a break down in red blood cells causing anaemia which may impair your heart function or worsen symptoms of heart disease.
Croatian: Hemoliza: Ribavirin Mylan može prouzročiti raspad crvenih krvnih zrnaca što dovodi do anemije koja može oštetiti funkciju srca ili pogoršati simptome bolesti srca.
English: BGP Products SRLTel: +40 372 579 000
Croatian: BGP Products SRL Tel: +40 372 579 000
English: The use of ribavirin in combination with peginterferon alfa-2b had no observable negative impact on the control of HIV viraemia during therapy or follow-up.
Croatian: Primjena ribavirina u kombinaciji s peginterferonom alfa-2b nije imala zabilježenih negativnih učinaka na kontrolu HIV viremije tijekom terapije ili perioda praćenja
English: Within the organ system classes, adverse reactions are listed under headings of frequency using the following categories: very common (≥ 1/10); common (≥ 1/100 to < 1/10), and uncommon (≥ 1/1,000 to <1/100).
Croatian: Nuspojave su razvrstane prema organskim sustavima i kategorijama učestalosti definiranima na sljedeći način: često (≥ 1/10), često (≥ 1/100 i < 1/10) i manje često (≥ 1/1000 i < 1/100).
English: Because of co-administration with interferon alfa-2b: - Autoimmune hepatitis; or history of autoimmune disease.
Croatian: Zbog primjene u kombinaciji s interferonom alfa-2b: - autoimuni hepatitis ili autoimuna bolest u anamnezi.
English: - anti-Human Immunodeficiency Virus (HIV) medicines - [nucleoside reverse transcriptase inhibitor (NRTI), and/or combined anti-retroviral therapy (cART)]:
Croatian: Nucleoside Reverse Transcriptase Inhibitor, NRTI) i/ili kombinirana antiretrovirusna terapija (engl. combined Antiretroviral Therapy (cART)]:
English: Adding treatment with an alpha interferon alone or in combination with ribavirin may increase the risk in this patient subset.
Croatian: Uvođenje liječenja samo alfa interferonom ili u kombinaciji s ribavirinom može povećati rizik u ovoj podskupini bolesnika.
English: Among children and adolescents, treated with Ribavirin in combination with interferon alfa2b, suicidal ideation or attempts were reported more frequently compared to adult patients (2.4% versus 1%) during treatment and during the 6-month follow-up after treatment.
Croatian: U djece i adolescenata liječenih lijekom Ribavirin Mylan u kombinaciji s interferonom alfa-2b suicidalne misli ili pokušaji samoubojstva prijavljeni su češće nego u odraslih bolesnika (2,4 % u odnosu na 1 %), i to tijekom liječenja i tijekom šestomjesečnog praćenja nakon završetka liječenja.
English: This myelotoxicity was reversible within 4 to 6 weeks upon withdrawal of HCV antiviral therapy and concomitant azathioprine and did not recur upon reintroduction of either treatment alone (see section
Croatian: Ova je mijelotoksičnost bila reverzibilna unutar 4 do 6 tjedana nakon ukidanja istodobne primjene antivirusne terapije protiv HCV-a i azatioprina i nije se ponovila nakon ponovnog uvođenja bilo kojeg od tih liječenja zasebno (vidjeti dio 4.5).
English: Ribavirin Mylan must be used in combination with interferon alfa-2b (3 million international units [MIU] three times a week).
Croatian: Ribavirin Mylan se mora uzimati u kombinaciji s interferonom alfa-2b (3 milijuna internacionalnih jedinica [MIU] triput tjedno).
English: Table 3 Management of Adverse Reactions Laboratory Values
Croatian: Tablica 3 Rješavanje nuspojava Laboratorijske vrijednosti
English: As in adult patients, children and adolescents experienced other psychiatric adverse reactions (e.g., depression, emotional lability, and somnolence).
Croatian: Kao i u odraslih bolesnika, u djece i adolescenata opisane su i druge psihijatrijske nuspojave (npr. depresija, emocionalna labilnost i somnolencija).
English: In case of serious adverse reaction potentially related to medicinal products used in combination with Ribavirin Mylan, refer to the corresponding SmPC of these medicinal products as some combination regimens do not adhere to the ribavirin dose modification and/or discontinuation guidelines as described in Table 2.
Croatian: U slučaju ozbiljnih nuspojava koje su potencijalno povezane s lijekom koji se primjenjuje istodobno s lijekom Ribavirin Mylan, pogledajte Sažetak opisa svojstava lijeka tih lijekova jer se u nekim režimima kombinacije lijekova ne primjenjuju smjernice za izmjenu doze ribavirina i/ili za prekid doziranja koje su opisane u Tablici 2.
English: Most of the changes in laboratory values in the ribavirin /peginterferon alfa-2b clinical trial were mild or moderate.
Croatian: Promjene u laboratorijskim vrijednostima u kliničkom ispitivanju lijeka ribavirina/peginterferona alfa-2b bile su većinom blage ili umjerene.
English: Table 2 Management of Adverse Reactions Laboratory Values
Croatian: Tablica 2 Rješavanje nuspojava Laboratorijske vrijednosti
English: Pancytopenia and bone marrow suppression have been reported in the literature to occur within 3 to 7 weeks after the administration of a peginterferon and ribavirin concomitantly with azathioprine.
Croatian: U literaturi je prijavljena pojava pancitopenije i supresije koštane srži unutar 3 do 7 tjedana nakon početka primjene peginterferona i ribavirina istodobno s azatioprinom.
English: 84 hard capsules 112 hard capsules 140 hard capsules 168 hard capsules
Croatian: 84 tvrdih kapsula 112 tvrdih kapsula 140 tvrdih kapsula 168 tvrdih kapsula
English: HCV-RNA should be measured periodically during treatment (see section 4.2).
Croatian: Povremeno se tijekom liječenja mora mjeriti razina HCV-RNK (vidjeti dio 4.2).
English: Combination therapy with ribavirin and interferon alfa-2b resulted in a sustained virological response that was ten-fold higher than that with interferon alfa-2b alone (49% vs 5 %, p < 0.0001).
Croatian: Kombinirana terapija ribavirinom i interferonom alfa-2b povećala je trajan virološki odgovor koji je bio 10 puta viši nego kod liječenja samo interferonom alfa-2b (49 % u odnosu na 5 %, p < 0,0001).
English: Adult patients with moderate renal impairment (creatinine clearance of 30-50 mL/minute) should be administered alternating daily doses of 200 mg and 400 mg.
Croatian: Odrasli bolesnici s umjerenim oštećenjem bubrega (klirens kreatinina 30 - 50 ml/min) trebaju primijeniti naizmjenične dnevne doze od 200 mg i 400 mg.
English: The pharmacokinetics of ribavirin is altered in patients with renal dysfunction due to reduction of apparent creatinine clearance in these patients (see section 5.2).
Croatian: Farmakokinetika ribavirina promijenjena je u bolesnika s oštećenom funkcijom bubrega zbog smanjenog klirensa kreatinina u tih bolesnika (vidjeti dio 5.2).
English: Single-dose pharmacokinetics of ribavirin in patients with mild, moderate or severe hepatic dysfunction (Child-Pugh Classification A, B or C) is similar to those of normal controls.
Croatian: Farmakokinetika jedne doze ribavirina u bolesnika s blagim, umjerenim ili teškim oštećenjem funkcije jetre (Child-Pugh stadij A, B ili C) bila je slična onoj u ispitanika s normalnom jetrenom funkcijom.