FrancophonIA/ELRC3.0 huggingface dataset:
English: Topamax belongs to a group of medicines called “antiepileptic medicines.” It is used:
Danish: Topimax tilhører en gruppe medicin, der kaldes antiepileptika.
English: The results from the ANCOVA models indicate that age did not have an impact on treatment effect (pvalue>=0.20) for all three seizure types (POS, PGTS, or LGS).
Danish: Resultaterne fra ANCOVA-modellerne viser, at alderen ikke havde indflydelse på behandlingens virkning (p-værdi>=0,20) for alle tre anfaldstyper (partielle anfald, primært generaliserede toniskkloniske anfald og Lennox-Gastauts syndrom).
English: • with other medicines to treat seizures in adults and children over age 2
Danish: • sammen med anden medicin til behandling af epilepsi (kramper) hos voksne og børn over 2 år
English: The second column (concomitant drug concentration) describes what happens to the concentration of the concomitant drug listed in the first column when topiramate is added.
Danish: Den anden kolonne (koncentration af samtidigt administreret lægemidler) beskriver, hvordan koncentrationen af lægemidlet opført i den første kolonne påvirkes, når topiramat er givet i tillæg.
English: The evidence to support paediatric use in PGTC Seizures has been provided from Studies YTC and YTC-E.
Danish: Evidensen til støtte for pædiatrisk brug ved primært generaliserede tonisk-kloniske anfald stammer fra YTC og YTC-E-undersøgelserne.
English: • Eye problems including dry eyes, light sensitivity, involuntary twitching, tearing and decreased vision
Danish: • Øjenproblemer f.eks. tørre øjne, lysfølsomhed, ufrivillige trækninger, tåreflåd og nedsat syn
English: Dose and titration rate in children should be guided by clinical outcome.
Danish: Dosis og titreringshastighed i børn bør justeres ud fra den kliniske effekt.
English: The third column (topiramate concentration) describes how the coadministration of a drug listed in the first column modifies the concentration of topiramate.
Danish: Den tredje kolonne (topiramatkoncentration) beskriver, hvordan samtidig indgift af lægemidlet i den første kolonne påvirker koncentrationen af topiramat.
English: In a single-dose study, serum digoxin area under plasma concentration curve (AUC) decreased 12% due to concomitant administration of Topamax.
Danish: I et enkeltdosisforsøg faldt arealet under plasmakoncentrationskurven (AUC) med 12% ved samtidig administration af topiramat.
English: • Excessive skin sensitivity
Danish: • Ekstrem hudfølsomhed
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Carton for alu/alu blister
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Karton til alu/alu blister
English: • Disturbances in sexual function (erectile dysfunction, loss of libido)
Danish: • Seksuelle forstyrrelser (rejsningsproblemer, tab af lyst til sex)
English: • Drowsiness or sleepiness
Danish: • Døsighed eller søvnighed
English: Janssen-Cilag International NV - BE Turnhoutseweg 30, B-2340 Beerse, Belgium
Danish: Janssen-Cilag International NV - BE Turnhoutseweg 30, B-2340 Beerse, Belgien
English: Titration should begin at 25 mg (or less, based on a range of 1 to 3 mg/kg/day) nightly for the first week.
Danish: Titreringen bør begynde med 25 mg/døgn eller derunder (1-3 mg/kg/døgn) til natten i den første uge.
English: Topiramate
Danish: Topiramat
English: The clinical significance of the effect of metformin on topiramate pharmacokinetics is unclear.
Danish: Den kliniske betydning af metformins effekt på topiramats farmakokinetik er uklar.
English: • Each Topamax hard capsule contains 15, 25, 50 mg of topiramate.
Danish: • Hver Topimax hård kapsel indeholder 15, 25, 50 mg topiramat.
English: Vertigo, tinnitus, ear pain
Danish: Vertigo, tinnitus, ørepine
English: • Each Topamax film-coated tablet contains 25, 50, 100, 200 mg of topiramate.
Danish: • Hver Topimax filmovertrukne tablet indeholder 25, 50, 100, 200 mg topiramat.
English: There have been no clinical studies evaluating this potential interaction.
Danish: Denne potentielle interaktion er ikke blevet evalueret i kliniske studier.
English: 6.4 Special precautions for storage [To be completed nationally]
Danish: 6.4 Særlige opbevaringsforhold [udfyldes nationalt]
English: Dizziness, tiredness, and vision problems may occur during treatment with Topamax.
Danish: Svimmelhed, træthed og synsforstyrrelser kan forekomme under behandling med Topimax.
English: The supplemental dose should be administered in divided doses at the beginning and completion of the haemodialysis procedure.
Danish: Den supplerende dosis bør fordeles på doser, der gives henholdsvis, når dialysen påbegyndes, og når den afsluttes.
English: Some patients may experience a benefit at a total daily dose of 50 mg/day.
Danish: Nogle patienter kan have gavnlig effekt med 50 mg/døgn.
English: • Topamax tablets are to be swallowed whole.
Danish: • Tabletterne skal synkes hele.
English: Effects of Topamax on other antiepileptic medicinal products
Danish: Effekt af Topimax på andre antiepileptika
English: Topiramate is effectively removed from plasma by haemodialysis.
Danish: Topiramat kan fjernes effektivt fra plasma ved hæmodialyse.
English: St John's Wort (Hypericum perforatum).
Danish: Perikon (Hypericum perforatum)
English: Calculus ureteric, renal tubular acidosis*
Danish: Ureterolithiasi s, renal tubulær acidose*
English: • Loss of sensitivity to touch in the mouth
Danish: • Tab af berøringsfølelsen i munden
English: In patients with impaired renal function (CLCR ≤ 60 mL/min) topiramate should be administered with caution as the plasma and renal clearance of topiramate are decreased.
Danish: Hos patienter med nedsat nyrefunktion (kreatininclearance ≤ 60 ml/min) bør topiramat administreres med forsigtighed, da plasma- og renal clearance af topiramat er nedsat.
English: Roderveldlaan 1 B-2600 Berchem, Belgium
Danish: Roderveldlaan 1 B-2600 Berchem, Belgien
English: Topiramate is not a potent inducer of drug metabolizing enzymes, can be administered without regard to meals, and routine monitoring of plasma topiramate concentrations is not necessary.
Danish: Det kan administreres uafhængigt af måltider, og rutinemæssig monitorering af plasmakoncentrationer er ikke nødvendig.
English: This effect was not blocked by flumazenil, a benzodiazepine antagonist, nor did topiramate increase the duration of the channel open time, differentiating topiramate from barbiturates that modulate GABAA receptors.
Danish: Topiramat forøgede heller ikke længden af kanalens åbningstid, hvilket adskiller topiramat fra de barbiturater, som modulerer GABAA-receptorerne.
English: Czech Republic Janssen-Cilag s.r.o - CZ Karla Engliše 3201/6
Danish: Janssen-Cilag s.r.o - CZ Karla Engliše 3201/6 150 00 Praha 5
English: ↔ 17% increase in Cmax for 4OH propranolol (TPM 50 mg q12h)
Danish: ↔ 17% øget Cmax af 4-OHpropranolol (TPM (topiramat) 50 mg hver 12. time)
English: The pharmacokinetics of topiramate in children, as in adults receiving add-on therapy, are linear, with clearance independent of dose and steady-state plasma concentrations increasing in proportion to dose.
Danish: Som hos voksne i adjuverende behandling er farmakokinetikken af topiramat hos børn lineær med clearance uafhængig af dosis og med et proportionalt forhold mellem dosis og steady-state plasmakoncentration.
English: The safety of topiramate was evaluated from a clinical trial database consisting of 4,111 patients (3,182 on topiramate and 929 on placebo) who participated in 20 double-blind trials and 2,847 patients who participated in 34 open-label trials, respectively, for topiramate as adjunctive treatment of primary generalized tonic-clonic seizures, partial onset seizures, seizures associated with Lennox-Gastaut syndrome, monotherapy for newly or recently diagnosed epilepsy or migraine prophylaxis.
Danish: Sikkerheden af topiramat er evalueret ud fra en klinisk forsøgsdatabase, bestående af 4.111 patienter (3.182 på topiramat og 929 på placebo), som har deltaget i 20 dobbelt-blindede forsøg, henholdsvis 2.847 patienter, der har deltaget i 34 ikke-blindede forsøg.
English: The clinical significance of these findings is not known.
Danish: Den kliniske betydning af disse resultater er ukendt.
English: Deafness, deafness unilateral, deafness neurosensory, ear discomfort, hearing impaired
Danish: Døvhed, ensidet døvhed, neurosensorisk døvhed, ubehag i øret, nedsat hørelse
English: Mothers who breastfeed while taking Topamax must tell the doctor as soon as possible if the baby experiences anything unusual.
Danish: Hvis du ammer under behandling med Topimax, skal du straks fortælle lægen, hvis dit barn opfører sig unormalt.
English: The results of covariate analyses in the studies TOPMAT-EPMN-104, TOPMAT-EPMN-105 and TOPMAT-EPMN-106 indicate that the efficacy of topiramate monotherapy did not differ as a function of age.
Danish: Resultaterne af kovariatanalyser i TOPMAT-EPMN-104-, TOPMAT-EPMN-105- og TOPMAT-EPMN-106-undersøgelserne viser, at virkningen af topiramat som monoterapi ikke var forskellig alt efter alder. Der er ingen data til støtte for en påstand om virkning som monoterapi hos patienter, der er under 6 år gamle.
English: United Kingdom Janssen-Cilag Limited - GB Saunderton
Danish: Storbritannien Janssen-Cilag Limited - GB Saunderton
English: Nephrolithiasis, pollakiuria, dysuria
Danish: Nefrolithiasis, pollakisuri, dysuri,
English: Dyspnoea exertional, Paranasal sinus hypersecretion, dysphonia
Danish: Anstrengelsesdys pnø, paranasal sinushypersekretion, dysfoni,
English: Alopecia, rash, pruritus
Danish: Alopeci, udslæt, pruritus
English: The precise mechanism by which topiramate exerts its antiseizure and migraine prophylaxis effects are unknown.
Danish: Den præcise mekanisme for, hvordan topiramat virker krampestillende og profylaktisk ved migræne, er ukendt.
English: Apraxia, circadian rhythm sleep disorder, hyperaesthesia, hyposmia, anosmia, essential tremor, akinesia, unresponsive to stimuli formication
Danish: Apraxi, søvnforstyrrelser i forhold til cirkadisk rytme, hyperæstesi, hyposmi, anosmi, essential tremor, akinesi, manglende respons på stimuli
English: Plasma clearance of topiramate is decreased in patients with moderate to severe hepatic impairment.
Danish: Plasmaclearance af topiramat er nedsat hos patienter med moderat til svær leverinsufficiens.
English: In healthy volunteers, there was an observed reduction (18% for AUC) in systemic exposure for lithium during concomitant administration with topiramate 200 mg/day.
Danish: Hos raske forsøgspersoner er der observeret en reduktion (18%) i AUC for lithium ved samtidig administration af 200 mg topiramat daglig.
English: 4.1 - Therapeutic Indications
Danish: 4.1 - Terapeutiske indikationer
English: The usual daily dose is 200-400 mg in two divided doses.”
Danish: Den sædvanlige daglige dosis er 200-400 mg fordelt på to separate doser.”
English: A contraindication for the use of topiramate for the indication of migraine prophylaxis in pregnancy and in women of childbearing potential if not using effective methods of contraception has been included in the SPC in sections 4.3 and 4.6.
Danish: En kontraindikation for brugen af topiramat til indikationen migræneprofylakse hos gravide og fertile kvinder, hvis ikke der anvendes effektive kontraceptionsmetoder, er medtaget i punkt 4.3 og punkt 4.6 i produktresuméet.
English: • have a history of blood and body fluid abnormality (metabolic acidosis)
Danish: • tidligere har haft unormale værdier for blodprøver og andre legemsvæsker (metabolisk acidose).
English: A drug-drug interaction study conducted in patients with type 2 diabetes evaluated the steady-state pharmacokinetics of glyburide (5 mg/day) alone and concomitantly with topiramate (150 mg/day).
Danish: I et interaktionsstudie med patienter med type-2 diabetes blev steady-state farmakokinetikken for glibenclamid (5 mg daglig) alene og sammen med topiramat (150 mg daglig) evalueret.
English: Acute myopia and secondary angle closure glaucoma
Danish: Akut myopi og sekundært snævervinklet glaukom:
English: The recommended initial target dose range for topiramate monotherapy in children over 6 years of age is 100 mg/day depending on clinical response, (this is about 2.0mg/kg/day in children 6-16 years).
Danish: Den anbefalede initiale måldosis ved monoterapi hos børn er 100 mg/døgn afhængigt af klinisk effekt, (det svarer til omkring 2,0 mg/kg/døgn for børn i alderen 6-16 år).
English: In rabbits, dosage-related maternal toxicity was noted down to 10 mg/kg/day with embryo/fetal toxicity (increased lethality) down to 35 mg/kg/day, and teratogenic effects (rib and vertebral malformations) at 120 mg/kg/day.
Danish: Hos kaniner blev dosisrelateret modertoksicitet observeret ved doser ned til 10 mg/kg/døgn, embryo/føtal toksicitet (øget dødelighed) ved doser ned til 35 mg/kg/døgn og teratogen effekt (misdannelser på ribben og rygsøjle) ved 120 mg/kg/døgn.
English: In acute topiramate overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis.
Danish: Ved akut overdosering med topiramat hvis topiramat er indtaget for nylig skal der øjeblikkeligt foretages ventrikeltømning eller fremprovokering af opkastning,.
English: UAB Johnson & Johnson - LT Geležinio Vilko g. 18A LT-08104 Vilnius Lithuania
Danish: UAB Johnson & Johnson - LT Geležinio Vilko g. 18A LT-08104 Vilnius Litauen
English: Janssen-Cilag SpA - IT Via Michelangelo Buonarroti n. 23 Cologno Monzese, 20093, Milano, Italy
Danish: Janssen-Cilag SpA - IT Via Michelangelo Buonarroti n. 23 Cologno Monzese, 20093, Milano, Italien
English: If the child is unable to tolerate the titration regimen, smaller increments or longer intervals between dose increments can be used.
Danish: Såfremt barnet ikke tåler titreringsregimet, kan en mindre dosisforøgelse eller længere intervaller mellem dosisøgning anvendes.
English: 4.3 - Contraindications
Danish: 4.3 - Kontraindikationer
English: In rats, dosage-related maternal and embryo/fetal toxicity (reduced fetal weights and/or skeletal ossification) were observed down to 20 mg/kg/day with teratogenic effects (limb and digit defects) at 400 mg/kg/day and above.
Danish: Hos rotter blev dosisrelateret moder- og embryo/føtal toksicitet (reduceret føtalvægt og/eller skeletal ossifikation) observeret ved doser ned til 20 mg/kg/døgn og teratogen effekt (misdannelser på lemmer og fingre/tæer) ved 400 mg/kg/døgn og derover.
English: A drug-drug interaction study conducted in healthy volunteers evaluated the steady-state pharmacokinetics of metformin and topiramate in plasma when metformin was given alone and when metformin and topiramate were given simultaneously.
Danish: Hos raske forsøgspersoner blev steady-state farmakokinetikken af metformin og topiramat i plasma evalueret, når metformin var givet alene, og når metformin og topiramat var givet samtidig.
English: Hypotension, orthostatic hypotension flushing, hot flush,
Danish: Hypotension, ortostatisk hypotension, rødmen, varmefølelse
English: Anhidrosis, hypoaesthesia facial, urticaria, erythema, pruritus generalised, rash macular, skin discolouration, dermatitis allergic, swelling face
Danish: Anhidrose, facial hypæstesi, urticaria, erytem, generaliseret pruritus, makulært udslæt, misfarvning af huden, allergisk dermatitis, hævelse i ansigtet
English: A pharmacokinetic interaction study of patients with epilepsy indicated the addition of topiramate to lamotrigine had no effect on steady state plasma concentration of lamotrigine at topiramate doses of 100 to 400 mg/day.
Danish: Et farmakokinetisk interaktionsforsøg med epilepsipatienter indikerede, at tillæg af topiramat i doser på 100-400 mg/døgn til lamotrigin ikke havde nogen effekt på steady-state plasmakoncentrationen af lamotrigin.
English: Janssen-Cilag Pharma GmbHPfarrgasse 75 A-1232 Wien, Austria
Danish: Janssen-Cilag Pharma GmbHPfarrgasse 75 A-1232 Wien, Østrig
English: 9% and17% increase in AUC (40 and 80 mg propranolol q12h respectively)
Danish: 9% og 16% øgning i Cmax, 9% og 17% øgning i AUC (40 og 80 mg propranolol hver 12. time respektivt)
English: • Involuntary movement of the eyes
Danish: • Ufrivillige øjenbevægelser
English: • have kidney problems, especially kidney stones, or are getting kidney dialysis
Danish: • har en nyresygdom, specielt nyresten, eller hvis du er i dialyse.
English: • Low potassium levels in the blood
Danish: • Nedsat kaliumindhold i blodet
English: Table 1: Topiramate Adverse Drug Reactions
Danish: Tabel 1: Topiramatbivirkninger
English: Adjunctive Therapy for Primary Generalized Tonic-Clonic (PGTC) Seizures in Adults and Children Two studies YTC and YTC-E, explored the efficacy of topiramate as adjunctive therapy in primary generalised tonic-clonic (PGTC) seizures patients.
Danish: Tillægsbehandling ved primært generaliserede tonisk-kloniske anfald hos børn og voksne I to undersøgelser, YTC og YTC-E, undersøgte man virkningen af topiramat som tillægsbehandling hos patienter med generaliserede tonisk-kloniske anfald.
English: Amitriptyline
Danish: Amitriptylin
English: When administered concomitantly with topiramate at escalating doses of 100, 250 and 400 mg/day there was a reduction in risperidone (administered at doses ranging from 1 to 6 mg/day) systemic exposure (16% and 33% for steady-state AUC at the 250 and 400 mg/day doses, respectively).
Danish: Når risperidon (i doser på 1-6 mg/døgn) blev givet samtidigt med topiramat i stigende doser på 100, 250 og 400 mg/døgn, sås en reduktion i den systemiske eksponering af risperidon (16% og 33% for steady-state AUC ved henholdsvis 250 og 400 mg/døgn).
English: Janssen-Cilag Pharma GmbH Pfarrgasse 75 A-1232 Wien, Austria
Danish: Janssen-Cilag Pharma GmbH Pfarrgasse 75 A-1232 Wien, Østrig
English: 4.6 - Pregnancy and Lactation
Danish: 4.6 - Graviditet og amning
English: • Topamax hard capsules may be swallowed whole or may be opened and sprinkled on a teaspoon of soft food of any type.
Danish: • Topimax hårde kapsler kan synkes hele eller kan åbnes forsigtigt og indholdet strøs ud på en teskefuld blød føde.
English: In patients with moderate to severe hepatic impairment topiramate should be administered with caution as the clearance of topiramate is decreased.
Danish: Hos patienter med moderat til alvorligt nedsat leverfunktion bør topiramat administreres med forsigtighed, da clearance af topiramat er nedsat.
English: The maximum recommended daily dose is 500 mg/day in 2 divided doses.
Danish: Den maksimalt anbefalede daglige dosis er 500 mg fordelt på 2 doser.
English: Hyperthermia, thirst, influenza like illness*, sluggishness, peripheral coldness, feeling drunk, feeling jittery
Danish: Hypertermi, tørst, influenzalignende symptomer*, ugidelighed, perifer kuldefornemmelse, følelse af at være beruset, følelse af at være anspændt
English: Therefore the harmonised indication for topiramate adjunctive therapy in partial onset seizures with or without secondary generalization or primary generalized tonic-clonic seizures in adults and in the paediatric population was supported by the CHMP:
Danish: Derfor støttede CHMP den harmoniserede indikation for tillægsbehandling med topiramat ved partielle anfald med eller uden sekundær generalisering eller primært generaliserede tonisk-kloniske anfald hos voksne og hos den pædiatriske population:
English: Pregnancy registry data suggest that there may be an association between the use of Topamax during pregnancy and congenital malformations (e.g., craniofacial defects, such as cleft lip/palate, hypospadias, and anomalies involving various body systems).
Danish: Data fra graviditetsregistre antyder, at der kan være en sammenhæng mellem brugen af Topimax under graviditeten og medfødte misdannelser (f.eks. i ansigt og kranie som f.eks. læbe- og ganespalte,
English: 6.5 Nature and contents of container [To be completed nationally] 6.6 Special precautions for disposal No special requirements.
Danish: 6.6 Regler for destruktion Ingen særlige forholdsregler.
English: Visual acuity reduced, scotoma, myopia*, abnormal sensation in eye*, dry eye, photophobia, blepharospasm, lacrimation increased, photopsia, mydriasis, presbyopia
Danish: Reduceret visuelt skarpsyn, skotom, myopi*, unormal følelse i øjet*, øjentørhed, fotofobi, blefarospasme, tåreflåd, fotopsi, mydriasis, presbyopi
English: • Swelling of the face.
Danish: • Hævelser af ansigtet
English: Arthralgia, muscle spasms, myalgia, muscle twitching, muscular weakness, musculoskeletal chest pain
Danish: Artralgi, muskelkramper, myalgi, musklertræknin ger, muskelsvaghed, muskuloskeletale brystsmerter
English: • have eye problems, especially glaucoma
Danish: • har en øjensygdom, specielt grøn stær (glaukom)
English: J.C. Healthcare srl - IT Via Michelangelo Buonarroti n. 23 Cologno Monzese, 20093, Milano, Italy
Danish: Healthcare srl - IT Via Michelangelo Buonarroti n. 23 Cologno Monzese, 20093, Milano, Italien
English: • Irregular heartbeat or slowness of the heart beat
Danish: • Uregelmæssig eller langsom hjerterytme (puls)
English: • Visual disturbance, blurred vision, double vision
Danish: • Synsforstyrrelser, sløret syn, dobbbeltsyn
English: Slovak Republic Johnson & Johnson, s.r.o - SK Plynárenská 7/B
Danish: Johnson & Johnson, s.r.o - SK Plynárenská 7/B 824 78 Bratislava Slovakiet
English: • Be sure to swallow the entire spoonful of the sprinkle/food mixture immediately.
Danish: • Sørg for at synke hele skefulden med mad og medicin med det samme.
English: Blindness unilateral, blindness transient, glaucoma, accommodation disorder, altered visual depth perception, scintillating scotoma, eyelid oedema*, night blindness, amblyopia
Danish: Ensidet blindhed, forbigående blindhed, glaukom, akkomodation sforstyrrelser, ændret opfattelse af synsdybde, flimreskotom, øjenlågsødem natteblindhed, amblyopi
English: Hyperchloremic, non-anion gap, metabolic acidosis (i.e. decreased serum bicarbonate below the normal reference range in the absence of respiratory alkalosis) is associated with topiramate treatment.
Danish: Hyperkloræmisk, non-anion gap metabolisk acidose (serum-hydrogencarbonat under det normale referenceinterval i fravær af respiratorisk acidose) er associeret med topiramat behandling og skyldes topiramats hæmmende virkning på renal kulsyreanhydrase.
English: • Decrease or loss of sweating
Danish: • Nedsat eller mistet evne til at svede
English: Two metabolites, which retained most of the structure of topiramate, were tested and found to have little or no anticonvulsant activity.
Danish: To metabolitter, som overvejende har bibeholdt topiramats struktur, blev testet.
English: Angle closure glaucoma*, Maculopathy* , eye movement disorder*
Danish: Snævervinklet glaukom*, maculopati*, forstyrrelser i øjebevæ-gelserne*
English: Topamax, when used concomitantly with other agents predisposing to nephrolithiasis, may increase the risk of nephrolithiasis.
Danish: Når Topimax administreres samtidigt med andre lægemidler, der disponerer for nefrolithiasis, øges risikoen for nefrolithiasis.
English: Dose and titration should be guided by clinical response.
Danish: Dosis og titrering bør justeres efter det kliniske respons.
English: Especially, tell your doctor or pharmacist if you are taking:
Danish: Tal med din læge eller med apoteket, hvis du tager
English: In nonclinical studies of fertility, despite maternal and paternal toxicity as low as 8 mg/kg/day, no effects on fertility were observed, in male or female rats with doses up to 100 mg/kg/day.
Danish: På trods af toksicitet på doser helt ned til 8 mg/kg/døgn hos moder- og faderdyr viste nonkliniske undersøgelser ingen effekt på fertiliteten hos han- eller hunrotter med doser op til 100 mg/kg/døgn.
English: Titration should begin at 25 mg nightly for 1 week.
Danish: Titrering bør initieres med 25 mg til natten i en uge.
English: The recommended total daily dose of Topamax (topiramate) as adjunctive therapy is approximately 5 to 9 mg/kg/day in two divided doses.
Danish: Den anbefalede daglige topiramatdosis ved adjuverende behandling er ca. 5-9 mg/kg/døgn fordelt på 2 doser.