FrancophonIA/ELRC3.0 huggingface dataset:
English: • Once added as recommended into the infusion bag, the docetaxel infusion solution, if stored below 25°C, is stable for 6 hours.
Danish: • Efter den anbefalede tilsætning til infusionsposen er docetaxelinfusionsopløsningen stabil i 6 timer, hvis den opbevares under 25°C.
English: The median number of cycles administered per patient was 6 (with a range of 1-16) for the TCF arm compared to 4 (with a range of 1-12) for the CF arm. Time to progression (TTP) was the primary endpoint.
Danish: Medianantallet af cyklusser indgivet pr. patient var 6 (et interval på 1-16) for TCFarmen sammenlignet med 4 (et interval på 1-12) for CF-armen.
English: Without affecting the primary endpoint, overall response rate (32% vs 25%, p = 0.10), docetaxel prolonged median time to progression (24.6 weeks vs 15.6 weeks; p < 0.01) and median survival (15.3 months vs 12.7 months; p = 0.03).
Danish: Uden at påvirke det primære endepunkt, total responsrate (32% mod 25%, p = 0,10), forlængede docetaxel mediantiden til progression (24,6 uger mod 15,6 uger, p < 0,01) og medianoverlevelse (15,3 måneder mod 12,7 måneder, p = 0,03).
English: • Docetaxel 75 mg/m² every 3 weeks for 10 cycles.
Danish: • Docetaxel 75 mg/m² hver 3. uge i 10 cyklusser.
English: Once added to the infusion bag
Danish: Efter tilsætning til infusionpose
English: The combined administration of docetaxel, cisplatin and 5-fluorouracil in 12 patients with solid tumours had no influence on the pharmacokinetics of each individual medicinal product.
Danish: Den kombinerede administration af docetaxel, cisplatin og 5-floururacil hos 12 patienter med massive tumorer påvirkede ikke farmakokinetikken for hvert enkelt lægemiddel.
English: Previous chemotherapy should have included an anthracycline or an alkylating agent.
Danish: I tidligere kemoterapi skal antracyklin eller et alkylerende stof have været anvendt.
English: Infusion site reactions were generally mild and consisted of hyper pigmentation, inflammation, redness or dryness of the skin, phlebitis or extravasation and swelling of the vein.
Danish: Reaktionerne ved infusionsstedet var almindeligvis milde og bestod af hyperpigmentering, inflammation, rødmen eller tørhed i huden, flebititis eller blodudtrækninger og hævelse af venen.
English: Inject the required volume of concentrate for solution into a 250 ml infusion bag or bottle containing either 5% glucose solution or sodium chloride 9 mg/ml (0.9%) solution for infusion.
Danish: Injicer den nødvendige mængde koncentrat til infusionsvæske i en 250 ml infusionspose eller -flaske indeholdende enten 5% glukoseinfusionsvæske eller 9 mg/ml (0,9%) natriumkloridinfusionsvæske.
English: An open-label, multicenter, randomized phase III study was conducted to compare docetaxel monotherapy and paclitaxel in the treatment of advanced breast cancer in patients whose previous therapy should have included an anthracycline.
Danish: Et open-label, multicenter, randomiseret fase III-studie blev udført med henblik på at sammenligne docetaxel som monoterapi og paclitaxel til behandling af fremskreden brystcancer hos patienter, hvis tidligere behandling skulle have omfattet et antracyklin.
English: Two randomised phase III comparative studies, involving a total of 326 alkylating or 392 anthracycline failure metastatic breast cancer patients, have been performed with docetaxel at the recommended dose and regimen of 100 mg/m² every 3 weeks.
Danish: To randomiserede, fase III, komparative studier med hhv. 326 patienter og 392 patienter med metastatisk brystcancer, der tidligere uden effekt havde fået behandling med hhv. alkylerende stoffer eller antracykliner, blev udført med docetaxel ved det anbefalede dosisregime på 100 mg/m² hver 3. uge.
English: Both regimens were administered on day 1 every 3 weeks.
Danish: Begge regimer blev indgivet på første dagen hver tredje uge.
English: Median overall survival was also significantly longer in favour of the TPF arm compared to the PF arm (median OS: 18.6 vs. 14.5 months respectively) with a 28% risk reduction of mortality, p = 0.0128.
Danish: Total medianoverlevelse var også signifikant længere til fordel for TPF-armen (median for total overlevelse: 18,6 mod 14,5 måneder) med en 28% reduktion i risikoen for mortalitet, p = 0,0128.
English: One large randomized phase III study, involving 429 previously untreated patients with metastatic disease, has been performed with doxorubicin (50 mg/m²) in combination with docetaxel (75 mg/m²) (AT arm) versus doxorubicin (60 mg/m²) in combination with cyclophosphamide (600 mg/m²) (AC arm).
Danish: Et stort randomiseret fase III-studie med 429 tidligere ubehandlede patienter med metastatisk sygdom blev udført med doxorubicin (50 mg/m²) i kombination med docetaxel (75 mg/m²) (AT-arm) sammenlignet med doxorubicin (60 mg/m²) i kombination med cyclophosphamid (600 mg/m²) (ACarm).
English: Patients with severe fluid retention such as pleural effusion, pericardial effusion and ascites should be monitored closely.
Danish: Patienter med svær væskeretention i form af pleuralekssudat og perikardieekssudat samt ascites skal observeres nøje.
English: During the infusion at the hospital the following allergic reactions (may affect more than 1 in 10 people) may occur:
Danish: Følgende allergiske reaktioner (kan forekomme hos flere end 1 ud af 10 patienter) kan optræde under infusionen på hospitalet:
English: There was an increased incidence of SAEs (40% vs. 31%) and Grade 4 AEs (34% vs. 23%) in the trastuzumab combination arm compared to docetaxel monotherapy.
Danish: Der var en forøget forekomst af meget alvorlige bivirkninger (40% mod 31%) og grad 4 alvorlige bivirkninger (34% mod 23%) i kombinationsarmen trastuzumab sammenlignet med docetaxel enkeltbehandling.
English: Adjuvant therapy for breast cancer
Danish: Adjuverende behandling til brystcancer
English: Diarrhoea grade 3
Danish: Toksicitet Diarré grad 3
English: In the docetaxel, doxorubicin and cyclophosphamide (TAC) treated patients, the risk of delayed myelodysplasia or myeloid leukaemia requires haematological follow-up.
Danish: For patienter, behandlet med docetaxel, doxorubicin og cyclophosphamid (TAC), kræver risikoen for forsinket myelodysplasi eller myeloid leukæmi hæmatologisk opfølgning.
English: In anthracycline-failure patients, docetaxel was compared to the combination of mitomycin C and vinblastine (12 mg/m² every 6 weeks and 6 mg/m² every 3 weeks).
Danish: Hos patienter, som tidligere havde fået antracyklin uden effekt, blev docetaxel sammenlignet med kombinationen af Mitomycin C og Vinblastin (12 mg/m² hver 6. uge og 6 mg/m² hver 3. uge).
English: LIST OF EXCIPIENTS Excipients: polysorbate 80, ethanol anhydrous and citric acid.
Danish: Hjælpestoffer: polysorbat 80, ethanol, vandfri og citronsyre.
English: • For patients developing the first appearance of a Grade 2 toxicity, which persists at the time of the next docetaxel/capecitabine treatment, delay treatment until resolved to Grade 0-1, and resume at 100% of the original dose.
Danish: • Hos patienter, der første gang udvikler grad 2-toksicitet, der vedvarer til tidspunktet for den næste docetaxel/capecitabin-behandling skal behandlingen udsættes, til der er grad 0-1-toksicitet.
English: There are limited available data in patients > 70 years of age on docetaxel use in combination with doxorubicin and cyclophosphamide.
Danish: Der er begrænsede tilgængelige data vedrørende anvendelse af docetaxel i kombination med doxorubicin og cyclophosphamid til patienter over 70 år.
English: - For the treatment of lung cancer, docetaxel could be administered either alone or in combination with cisplatin.
Danish: - Ved behandling af lungekræft kan docetaxel enten indgives alene eller i kombination med cisplatin.
English: Data from a multicenter open label randomized study support the use of docetaxel for the adjuvant treatment of patients with operable node-positive breast cancer and KPS ≥ 80%, between 18 and 70 years of age.
Danish: Data fra et multicenter open-label randomiseret studie støtter anvendelsen af docetaxel til adjuverende behandling af patienter med operabel lymfeknude-positiv brystcancer og KPS ≥ 80% i alderen 18 til 70 år.
English: In first-line treatment, docetaxel 75 mg/m² is given in combination therapy with doxorubicin (50 mg/m²).
Danish: Som førstebehandling indgives 75 mg/m² doxetaxel i kombinationsbehandling med doxorubicin (50 mg/m²).
English: Docetaxel should be administered when the neutrophil count is ≥ 1,500 cells/mm3.
Danish: Docetaxel kan gives, når neutrofiltallet er ≥ 1.500 celler/mm3.
English: Data from one multicenter, randomised, controlled phase III clinical study support the use of docetaxel in combination with capecitabine for treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy, including an anthracycline.
Danish: Data fra et multicenter, randomiseret, kontrolleret fase-III klinisk studie understøtter brugen af docetaxel i kombination med capecitabin til behandling af patienter med lokalt fremskreden eller metastatisk brystcancer efter manglende effekt af cytotoksisk kemoterapi, herunder et antracyklin.
English: • weight gain or loss.
Danish: • vægtforøgelse eller vægttab
English: Asthenia persisted into the follow-up period (median follow-up time of 10 years and 5 months) and was observed to be ongoing in 12 patients (2.3 %) in TAC arm and 4 patients (0.8 %) in FAC arm.
Danish: Asteni persisterede ind i followup-perioden (median followup-tid var 10 år og 5 måneder) og blev fortsat observeret hos 12 patienter (2,3%) i TAC-armen og hos 4 patienter (0,8%) i FAC-armen.
English: A total of 449 patients were randomized to receive either docetaxel monotherapy 100 mg/m² as a 1 hour infusion or paclitaxel 175 mg/m² as a 3 hour infusion.
Danish: I alt 449 patienter blev randomiseret til enten monoterapi med 100 mg/m² docetaxel som en infusion over 1 time eller 175 mg/m² paclitaxel som en infusion over 3 timer.
English: In combination with capecitabine, for patients 60 years of age or more, a starting dose reduction of capecitabine to 75% is recommended (see capecitabine summary of product characteristics).
Danish: I kombination med capecitabin anbefales det at reducere startdosis af capecitabin til 75% hos patienter på 60 år eller ældre (Se: Produktresumé for capecitabin).
English: Both regimens were administered every 3 weeks.
Danish: Begge regimer blev indgivet hver 3. uge.
English: In case of Grade 4 thrombocytopenia the docetaxel dose should be reduced from 75 to 60 mg/m².
Danish: I tilfælde af grad 4-trombocytopeni bør dosis af docetaxel reduceres fra 75 mg/m² til 60 mg/m².
English: If not used immediately, in-use storage times and conditions are the responsibility of the user.
Danish: Hvis det ikke anvendes straks, er opbevaringstider og -forhold brugerens ansvar.
English: Mean values for total body clearance and steady-state volume of distribution were 21 l/h/m² and 113 l, respectively.
Danish: Gennemsnitsværdierne for den samlede kropsclearance og steady-state-distributionsvolumen var henholdsvis 21 l/h/m² og 113 l. Variationen fra person til person i den samlede kropsclearance var ca. 50%.
English: Adjuvant radiation therapy was prescribed according to guidelines in place at participating institutions and was given to 69% of patients who received TAC and 72% of patients who received FAC.
Danish: Adjuverende stråleterapi blev ordineret i henhold til gældende retningslinjer hos de deltagende institutioner og blev givet til 69% af patienterne i TAC-armen og 72% af patienterne i FAC-armen.
English: All except one patient in each arm were diagnosed with CHF more than 30 days after the treatment period.
Danish: Alle patienter undtagen en patient i hver arm blev diagnosticeret med CHF mere end 30 dage efter behandlingsperioden.To patienter i TAC-armen og 4 patienter i FAC-armen døde af hjertesvigt.
English: Both regimens were administered once every 3 weeks for 6 cycles.
Danish: Begge regimer blev administreret en gang hver 3. uge i 6 cyklusser.
English: 95% CI p-value
Danish: 95% CI p-værdi
English: • Aseptically withdraw the required amount of concentrate for solution for infusion with a calibrated syringe.
Danish: • Udtag den ønskede mængde af Docetaxel, koncentrat til infusionsvæske, opløsning aseptisk med en kalibreret sprøjte.
English: The concentrate is pale yellow to brownish-yellow.
Danish: Koncentratet er lysgul til brunlig gul.
English: In addition, physical and chemical in-use stability of the infusion solution prepared as recommended has been demonstrated in non-PVC bags up to 48 hours when stored between 2°C to 8°C.
Danish: Endvidere er den fysiske og kemiske stabilitet af infusionsvæsken tilberedt som anbefalet i PVC-frie infusionsposer påvist at være op til 48 timer ved opbevaring mellem 2°C og 8°C.
English: The pharmacokinetics of docetaxel have been evaluated in cancer patients after administration of 20-115 mg/m² in phase I studies.
Danish: Fase I-studier har undersøgt docetaxels farmakokinetik hos cancerpatienter efter indgift af 20-115 mg/m².
English: In chemotherapy naïve patients treated for non-small cell lung cancer, the recommended dose regimen is docetaxel 75 mg/m² immediately followed by cisplatin 75 mg/m² over 30-60 minutes.
Danish: For patienter, der ikke tidligere er behandlet med kemoterapi, der behandles for ikke-småcellet lungecancer, er den anbefalede dosis af docetaxel 75 mg/m², straks efterfulgt af cisplatin 75 mg/m² givet over 30-60 minutter.
English: When used in combination, docetaxel does not influence the clearance of doxorubicin and the plasma levels of doxorubicinol (a doxorubicin metabolite).
Danish: Docetaxel influerer ikke på clearance af doxorubicins eller plasmaniveauet af doxorubicinol (en doxorubicinmetabolit), når det anvendes i kombinations.
English: A multicenter, open-label, randomized study was conducted to evaluate the safety and efficacy of docetaxel for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who had not received prior chemotherapy for metastatic disease.
Danish: Et multicenter, open-label, randomiseret studie blev udført for at evaluere sikkerheden og virkningen af docetaxel i behandlingen af patienter med metastatisk gastrisk adenokarcinom, herunder adenokarcinom i den gastroøsofageale overgang, som ikke tidligere havde fået kemoterapi for en metastatisk sygdom.
English: Infection associated with G4 neutropenia (G3/4: 4.6%)
Danish: Infektion associeret med G4-neutropeni (G3/4: 4,6%)
English: - For the treatment of prostate cancer, docetaxel is administered in combination with prednisone or prednisolone.
Danish: - Ved behandling af prostatakræft indgives docetaxel i kombination med prednison eller prednisolon.
English: In Docetaxel Mylan, the concentration of docetaxel is 20 mg/ml.
Danish: Koncentrationen af docetaxel i Docetaxel Mylan er 20 mg/ml.
English: • Induction chemotherapy followed by radiotherapy (TAX323) The safety and efficacy of docetaxel in the induction treatment of patients with squamous cell carcinoma of the head and neck (SCCHN) was evaluated in a phase III, multicenter, open-label, randomized study (TAX323).
Danish: • Induktionskemoterapi efterfulgt af strålebehandling (TAX 323) Sikkerheden og effektiviteten af docetaxel ved induktionsbehandling af patienter med pladecellekarcinom i hoved og hals (SCCHN) blev evalueret i et fase III, multicenter, open-label, randomiseret studie (TAX 323).
English: Physical and chemical in-use stability of the infusion solution prepared as recommended has been demonstrated in non-PVC bags up to 48 hours when stored between 2°C to 8°C.
Danish: Den fysiske og kemiske stabilitet af infusionsvæsken tilberedt som anbefalet i PVC-frie infusionsposer er påvist at være op til 48 timer ved opbevaring mellem 2°C og 8°C.
English: First episode: reduce 5-FU dose by 20%.
Danish: Første episode: Reducer 5-FU-dosis med 20%.
English: Docetaxel Mylan concentrate for solution for infusion is a pale yellow to brownish-yellow solution.
Danish: Docetaxel Mylan koncentrat til infusionsvæske, opløsning er lysgul til brunlig gul.
English: The median TTP was 37.3 weeks (95% CI: 33.4-42.1) in AT arm and 31.9 weeks (95% CI: 27.4-36.0) in AC arm.
Danish: Median TTP var 37,3 uger (95% CI: 33,4-42,1) i AT-armen og 31,9 uger (95% CI: 27,4-36,0) i AC-armen.
English: Docetaxel Mylan in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer.
Danish: Docetaxel Mylan i kombination med prednison eller prednisolon er indiceret til behandling af patienter med hormonrefraktær metastatisk prostatacancer.
English: 5 vials of 10 ml
Danish: 5 hætteglas á 10 ml
English: • From a microbiological point of view, dilution must take place in controlled and aseptic conditions and the infusion solution should be used immediately.
Danish: • Fra et mikrobiologisk synspunkt skal fortynding foretages under kontrollerede og aseptiske forhold og lægemidlet bør anvendes umiddelbart herefter.
English: A total of 445 patients with KPS > 70 were treated with either docetaxel (T) (75 mg/m² on day 1) in combination with cisplatin (C) (75 mg/m² on day 1) and 5-fluorouracil (F) (750 mg/m² per day for 5 days) or cisplatin (100 mg/m² on day 1) and 5-fluorouracil (1000 mg/m² per day for 5 days).
Danish: I alt 445 patienter med KPS > 70 blev behandlet med enten docetaxel (T) (75 mg/m² på førstedagen) i kombination med cisplatin (C) (75 mg/m² på førstedagen) og 5-fluoruracil (F) (750 mg/m² pr. dag i 5 dage) eller cisplatin (100 mg/m² på førstedagen) og 5-fluoruracil (1.000 mg/m² pr. dag i 5 dage).
English: In GEICAM 9805 study, 3 patients (0.6 %) in TAC arm and 3 patients (0.6 %) in FAC arm developed congestive heart failure during the follow-up period.
Danish: I studiet GEICAM9805 udviklede 3 patienter (0,6%) i TAC-armen og 3 patienter (0,6%) i FAC-armen kongestivt hjertesvigt i followup-perioden.
English: General disorders and administration site conditions Radiation recall phenomena have rarely been reported.
Danish: Almene symptomer og reaktioner på administrationsstedet Der er i sjældne tilfælde rapporteret recallfænomener i forbindelse med strålebehandling.
English: 5 vials of 1 ml
Danish: 5 hætteglas á 1 ml
English: In patients treated with docetaxel in combination with cisplatin and 5-fluorouracil (TCF), febrile neutropenia and neutropenic infection occurred at lower rates when patients received prophylactic G-CSF.
Danish: Hos de patienter, der blev behandlet med docetaxel i kombination med cisplatin og 5-fluoruracil (TCF), opstod der febril neutropeni og neutropenisk infektion i mindre grad, når patienterne fik profylaktisk G¬CSF.
English: Median survival (months)
Danish: Medianoverlevelse (mdr.)
English: Infection (G3/4: 3.6%) Neutropenic infection
Danish: Infektion (G3/4: 3,6%) Neutropenisk infektion
English: The ORR was 59.3% (95% CI: 52.8-65.9) in AT arm versus 46.5% (95% CI: 39.8-53.2) in AC arm.
Danish: Den totale responsrate var 59,3% (95% CI: 52,8-65,9) i AT-armen og 46,5% (95% CI: 39,8-53,2) i AC-armen.
English: This regimen is administered every 3 weeks for 4 cycles.
Danish: Dette regime administreres hver 3. uge i 4 cyklusser.
English: More grade 3/4 adverse events were observed for docetaxel monotherapy (55.4%) compared to paclitaxel (23.0%).
Danish: Der blev observeret flere grad 3/4-bivirkninger ved monoterapi med docetaxel (55,4%) end paclitaxel
English: PSA** response rate (%) 95% CI p-value*
Danish: PSA** responsrate (%) 95% CI p-value*
English: In this study, 255 patients were randomised to treatment with docetaxel (75 mg/m² as a 1 hour intravenous infusion every 3 weeks) and capecitabine (1250 mg/m² twice daily for 2 weeks followed by 1-week rest period).
Danish: I dette studie blev 255 patienter randomiseret til behandling med docetaxel (75 mg/m² som intravenøs infusion over 1 time hver 3. uge) og capecitabin (1.250 mg/m² 2 gange dagligt i 2 uger efterfulgt af 1 uges pause).
English: Once added as recommended into the non-PVC infusion bag, the docetaxel infusion solution, if stored below 25°C, is stable for 6 hours.
Danish: Efter den anbefalede tilsætning til infusionsposen er docetaxelinfusionsopløsningen stabil i 6 timer, hvis den opbevares under 25°C.
English: Patients should not be retreated with subsequent cycles of docetaxel until neutrophils recover to a level > 1,500 cells/mm and platelets recover to a level > 100,000 cells/mm 3.
Danish: Patienter bør ikke genbehandles med efterfølgende cyklusser af docetaxel indtil neutrofil-antallet gendannes til et niveau > 1.500 celler/mm3 og blodplader gendannes til et niveau
English: Docetaxel in combination with doxorubicin and cyclophosphamide: adjuvant therapy
Danish: Docetaxel i kombination med doxorubicin og cyclophosphamid: adjuverende behandling
English: 5 vials of 4 ml
Danish: 5 hætteglas á 4 ml
English: Vascular disorders Venous thromboembolic events have rarely been reported.
Danish: Vaskulære sygdomme Der er rapporteret sjældne tilfælde af venøse tromboemboliske hændelser.
English: Cases of lacrimation with or without conjunctivitis, as cases of lacrimal duct obstruction resulting in excessive tearing have been rarely reported.
Danish: Der er rapporteret sjældne tilfælde af tåreproduktion med eller uden konjunktivitis, samt tilfælde af tilstoppede tårekanaler, som medfører overdreven epiphora.
English: Efficacy of docetaxel in the induction treatment of patients with inoperable locally advanced SCCHN (Intent-to-Treat Analysis)
Danish: Effekten af docetaxel i induktionsbehandlingen af patienter med inoperabel, lokalt fremskredent SCCHN (intent-to-treat-analyse)
English: Each ml of concentrate for solution for infusion contains 395 mg of ethanol anhydrous.
Danish: Hver ml koncentrat til infusionsvæske, opløsning indeholder 395 mg vandfri ethanol.
English: Efficacy of docetaxel in the induction treatment of patients with locally advanced SCCHN (Intent-toTreat Analysis)
Danish: Effekten af docetaxel i induktionsbehandlingen af patienter med lokalt fremskredent SCCHN (intentto-treat-analyse)
English: Docetaxel Mylan in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.
Danish: Docetaxel Mylan i kombination med cisplatin og 5-fluoruracil er indiceret til indledende behandling af patienter med lokalt, fremskreden pladecellekarcinom i hoved og hals.
English: • tiredness; or flu-like symptoms
Danish: • træthed eller influenzalignende symptomer
English: In GEICAM 9805 study, amenorrhoea persisted into the follow-up period (median follow-up time of 10 years and 5 months) and was observed to be ongoing in 18 patients (3.4 %) in TAC arm and 5 patients (1.0 %) in FAC arm.
Danish: I studiet GEICAM9805 persisterede amenorré ind i followup-perioden (median followup-tid var 10 år og 5 måneder) og blev fortsat observeret hos 18 patienter (3,4%) i TAC-armen og hos 5 patienter (1,0%) i FAC-armen.
English: Primary G-CSF prophylaxis should be considered in patients who receive adjuvant therapy with TAC for breast cancer to mitigate the risk of complicated neutropenia (febrile neutropenia, prolonged neutropenia or neutropenic infection).
Danish: Primær G¬CSF-profylakse bør overvejes til patienter, som får adjuverende behandling med TAC for brystcancer for at nedsætte risikoen for kompliceret neutropeni (febril neutropeni, prolongeret neutropeni eller neutropenisk infektion).
English: In patients treated with docetaxel in combination with doxorubicin and cyclophosphamide (TAC), febrile neutropenia and/or neutropenic infection occurred at lower rates when patients received primary G-CSF prophylaxis.
Danish: Hos patienter, der blev behandlet med docetaxel i kombination med doxorubicin og cyclophosphamid (TAC), opstod febril neutropeni og/eller neutropenisk infektion sjældnere, når patienterne fik primær G¬CSF-profylakse.
English: For cisplatin and 5-fluorouracil dose adjustments, see the corresponding summary of product characteristics.
Danish: For cisplatin- og 5-fluoruracil-dosisjusteringer: Se tilsvarende produktresuméer.