FrancophonIA/ELRC3.0 huggingface dataset:
English: Analyses of observational data suggest an increased risk of acute NAION in men with erectile dysfunction following exposure to PDE5 inhibitors such as vardenafil, tadalafil and sildenafil (see section 4.8).
Danish: Analyser af observationsdata tyder på, at der er en øget risiko for akut NAION hos mænd med erektil dysfunktion efter eksponering for PDE5-hæmmere, såsom vardenafil, tadalafil og sildenafil (se pkt.
English: Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure in patients taking vardenafil.
Danish: Gradvis stigning i doseringen af alfa-blokker kan være associeret med yderligere reduktion af blodtryk hos patienter, der får vardenafil.
English: Medicinal products for the treatment of erectile dysfunction should be used with caution in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie's disease), or in patients who have conditions which may predispose them to priapism (such as sickle cell anaemia, multiple myeloma or leukaemia).
Danish: Lægemidler til behandling af erektil dysfunktion bør anvendes med forsigtighed hos patienter med anatomisk deformitet af penis (som f.eks. vinkling, kavernøs fibrose eller Peyronie's sygdom) eller hos patienter med lidelser, som kan prædisponere til priapisme (som f.eks. seglcellanæmi, multipelt myelom eller leukæmi).
English: Medicinal products for the treatment of erectile dysfunction should generally not be used in men for whom sexual activity is inadvisable (e.g. patients with severe cardiovascular disorders such as unstable angina or severe cardiac failure [New York Heart Association III or IV]).
Danish: Generelt bør lægemidler til behandling af erektil dysfunktion ikke anvendes af mænd som frarådes seksuel aktivitet (f.eks. patienter med alvorlige kardiovaskulære lidelser som ustabil angina pectoris eller alvorligt hjertesvigt [New York Heart Association III eller IV]).
English: How to take Levitra
Danish: Sådan skal De tage Levitra
English: There is no relevant indication for use of Levitra orodispersible tablets in children and adolescents.
Danish: Der er ingen relevante indikationer for brug af Levitra smeltetabletter til børn og unge.
English: The relative bioavailability of glibenclamide (3.5 mg) was not affected when co-administered with vardenafil (20 mg).
Danish: Den relative biotilgængelighed af glibenclamid (3,5 mg) blev ikke påvirket af samtidig indgift af vardenafil (20 mg).
English: (≥1/100 to
Danish: (≥1/100 til,
English: Vardenafil is rapidly absorbed after administration of Levitra 10 mg orodispersible tablets without water.
Danish: Vardenafil absorberes hurtigt efter indgift af Levitra 10 mg smeltetabletter uden vand.
English: Take special care with Levitra
Danish: Vær ekstra forsigtig med at tage Levitra
English: In patients with mild to moderate hepatic impairment (Child-Pugh A and B), the clearance of vardenafil was reduced in proportion to the degree of hepatic impairment.
Danish: Hos patienter med let til moderat nedsat leverfunktion (Child-Pugh A og B) reduceredes vardenafil clearance proportionelt med graden af den nedsatte leverfunktion.
English: This in turn results in smooth muscle relaxation, allowing increased inflow of blood into the penis.
Danish: Dette bevirker en afslapning af den glatte muskulatur og tillader blodet at strømme til penis.
English: Levitra orodispersible tablets must be taken without liquid and immediately upon release from the blister.
Danish: Levitra smeltetabletter skal indtages uden væske straks efter, at den er taget ud af blisterpakningen.
English: - If you have a severe heart or liver problem.
Danish: - Hvis De har et alvorligt hjerte- eller leverproblem.
English: The onset of activity may be delayed if taken with a high fat meal (see section 5.2).
Danish: Indsætning af effekt kan forsinkes, hvis tabletterne tages sammen med et fedtrigt måltid (se pkt.5.2).
English: After oral dosing of vardenafil AUC and Cmax increase almost dose proportionally over the recommended dose range (5 - 20 mg).
Danish: Efter oral indgift af vardenafil øgedes AUC og Cmax næsten proportionalt med dosis over det anbefalede dosisområde (5 - 20 mg).
English: This leaflet was last revised in {month YYYY}.
Danish: Denne indlægsseddel blev senest ændret {måned ÅÅÅÅ}
English: - If you are taking medicines containing nitrates, such as glycerol trinitrate for angina, or nitric oxide donors, such as amyl nitrite.
Danish: - Hvis De tager medicin, som indeholder nitrater, som nitroglycerin for angina, eller nitrogenoxid-donorer som amylnitrit.
English: Levitra is not indicated for individuals below 18 years of age.
Danish: Levitra er ikke indiceret til personer under 18 år.
English: Visual defects and cases of non-arteritic ischemic optic neuropathy (NAION) have been reported in connection with the intake of Levitra and other PDE5 inhibitors.
Danish: Der er rapporteret synsdefekter og tilfælde af non-arteritis anterior iskæmisk opticusneuropati (NAION) i forbindelse med indtagelse af Levitra og andre PDE5-hæmmere.
English: In volunteers with severe renal impairment (creatinine clearance <30 ml/min) the mean AUC was increased by 21% and the mean Cmax decreased by 23%, compared to volunteers with no renal impairment.
Danish: Hos frivillige forsøgspersoner med alvorlig nyreinsufficiens (kreatininclearance <30 ml/min) øgedes den gennemsnitlige AUC med 21% og den gennemsnitlige Cmax faldt med 23% sammenlignet med frivillige forsøgspersoner uden nedsat nyrefunktion.
English: See section 2 “Levitra 10 mg orodispersible tablets contain Aspartame and Sorbitol”.
Danish: Se punkt 2 ”Levitra 10 mg smeltetabletter indeholder aspartam og sorbitol”:
English: Please tell your doctor or pharmacist if you are using, have recently used or might use any other medicines, including medicines obtained without a prescription.
Danish: Fortæl altid lægen eller på apoteket, hvis De bruger anden medicin eller har gjort det for nylig.
English: In a penile plesthysmography (RigiScan) study, vardenafil 20 mg produced erections considered sufficient for penetration (60% rigidity by RigiScan) in some men as early as 15 minutes after dosing.
Danish: I en penis-pletysmografiundersøgelse (RigiScan) bevirkede vardenafil 20 mg en erektion vurderet tilstrækkelig til gennemførelse af samleje (60% stivhed i RigiScan), hos nogle mænd allerede 15 minutter efter indtagelse.
English: When vardenafil film-coated tablets are taken with a high fat meal (containing 57% fat), the rate of absorption is reduced, with an increase in the median tmax of 1 hour and a mean reduction in Cmax of 20%.
Danish: Ved indgift af vardenafil filmovertrukne tabletter sammen med et fedtrigt måltid (indeholdende 57% fedt) reduceres absorptionshastigheden med en øgning af median Tmax på en time og en gennemsnitlig sænkning af Cmax på 20%.
English: Effects of vardenafil on other medicinal products
Danish: Virkninger af vardenafil på andre præparater
English: No effect on blood pressure was observed when nitroglycerin was taken 24 hours after administration of a single dose of vardenafil 20 mg film-coated tablets.
Danish: Der sås ingen effekt på blodtrykket når nitroglycerin blev indtaget 24 timer efter administration af en enkelt dosis vardenafil 20 mg filmovertrukne tabletter.
English: Mean vardenafil AUC was increased by 21 to 29% (middle aged and elderly ED patients) or 44% (young healthy subjects) with 10 mg orodispersible tablets compared to film-coated tablets as a result of local oral absorption of a small amount of drug in the oral cavity.
Danish: Middelværdien for AUC steg med 21-29% (midaldrende og ældre EDpatienter) eller 44% (unge raske forsøgspersoner) ved 10 mg smeltetabletter sammenlignet med filmovertrukne tabletter på grund af absorption af en lille mængde lægemiddel lokalt i mundhulen.
English: Vardenafil 10 mg orodispersible tablets must be taken without liquid.
Danish: Vardenafil 10 mg smeltetabletter skal tages uden væske.
English: Levitra is not for use by women.
Danish: Levitra er ikke beregnet til brug hos kvinder.
English: Increase in intraocular pressure Lacrimation increased
Danish: Øget intraokulært tryk Øget tåreflåd
English: The following patient groups were represented: elderly (22%), patients with hypertension (35%), diabetes mellitus (29%), ischaemic heart disease and other cardiovascular diseases (7%), chronic pulmonary disease (5%), hyperlipidaemia (22%), depression (5%), radical prostatectomy (9%).
Danish: De følgende patientgrupper var repræsenteret: Ældre (22%), patienter med hypertension (35%), diabetes mellitus (29%), iskæmisk hjertesygdom og andre kardiovaskulære sygdomme (7%), kronisk lungesygdom (5%), hyperlipidæmi (22%), depression (5%), radikal prostatektomi (9%).
English: Vardenafil potently enhances the effect of endogenous nitric oxide in the corpus cavernosum by inhibiting PDE5.
Danish: Vardenafil øger kraftigt effekten af endogen nitrogenoxid i corpus cavernosum ved at hæmme PDE5.
English: It may be harmful for people with phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up because the body cannot remove it properly.
Danish: Det kan være skadeligt for personer med phenylketonuri (PKU, Føllings sygdom), en sjælden genetisk lidelse, hvor phenylalanin ophobes, fordi kroppen ikke kan fjerne det ordenligt.
English: - You can take Levitra orodispersible tablets with or without food but do not take this medicine with any liquid.
Danish: - De kan tage Levitra smeltetabletter uafhængigt af måltider - men tag ikke medicinen sammen med væske.
English: 1 x 1 orodispersible tablet in alu/alu perforated unit dose blister, 2 x 1 orodispersible tablets in alu/alu perforated unit dose blisters, 4 x 1 orodispersible tablets in alu/alu perforated unit dose blisters, 8 x 1 orodispersible tablets in alu/alu perforated unit dose blisters.
Danish: 1 x 1 smeltetablet i alu/alu perforeret enkeltdosisblister, 2 x 1 smeltetabletter i alu/alu perforeret enkeltdosisblister, 4 x 1 smeltetabletter i alu/alu perforeret enkeltdosisblister, 8 x 1 smeltetabletter i alu/alu perforeret enkeltdosisblister.
English: In those patients who are stable on alpha-blocker therapy, vardenafil should be initiated at the lowest recommended starting dose of 5 mg. Levitra may be administered at any time with tamsulosin or alfuzosin.
Danish: Hos de patienter, der er i stabil alfa-blokker-behandling, bør vardenafil initieres med den laveste anbefalede startdosis på 5 mg. Levitra kan administreres på et hvilket som helst tidspunkt med tamsulosin eller alfuzosin.
English: Based on efficacy and tolerability the dose may be increased to 20 mg or decreased to 5 mg.
Danish: På basis af effekt og tolerance kan dosis øges til 20 mg eller nedsættes til 5 mg.
English: The number of patients who returned to a normal IIEF domain score (>26) were 53% on vardenafil compared to 9% on placebo.
Danish: Antallet af patienter, som vendte tilbage til en normal erektil funktionsdomæne-score (>26), var 53% for vardenafil sammenlignet med 9% for placebo.
English: PP/Aluminium foil blisters in cartons of 2, 4, 8, 12 and 20 tablets.
Danish: PP/aluminiumsfolie-blisters i pakninger med 2, 4, 8.
English: The vardenafil results showed an increase in QTc (Fridericia) of 8 msec (90% CI: 6-9) and 10 msec (90% CI: 8-11) at 10 and 80 mg doses compared to placebo and an increase in QTci of 4 msec (90% CI: 3-6) and 6 msec (90% CI: 4-7) at 10 and 80 mg doses compared to placebo, at one hour post-dose.
Danish: Resultaterne for vardenafil viste en øgning i QTc (Fridericia) på 8 msek (90% CI: 6-9) og 10 msek (90% CI: 8-11) ved doser på 10 og 80 mg sammenlignet med placebo, og en øgning i QTci på 4 msek (90% CI: 3-6) og 6 msek (90% CI: 4-7) ved doser på 10 og 80 mg sammenlignet med placebo en time efter dosering.
English: - Place the entire orodispersible tablet in the mouth, on the tongue, where it will dissolve in seconds, then swallow with saliva.
Danish: - Placér hele smeltetabletten på tungen, hvor den bliver opløst på få sekunder.
English: Although specific interaction studies have not been conducted, the concomitant use of other potent CYP3A4 inhibitors (such as itraconazole) can be expected to produce vardenafil plasma levels comparable to those produced by ketoconazole.
Danish: Skønt der ikke er foretaget specifikke interaktionsundersøgelser, kan samtidig anvendelse af andre potente CYP3A4-inhibitorer (som itraconazol) forventes at medføre vardenafil plasmaniveauer sammenlignelige med dem frembragt af ketoconazol.
English: The recommended dose is 10 mg taken as needed approximately 25 to 60 minutes before sexual activity.
Danish: Den anbefalede dosis er 10 mg, som tages efter behov 25 til 60 minutter før seksuel aktivitet.
English: Therefore, inhibitors of these isoenzymes reduce vardenafil clearance.
Danish: Derfor reducerer hæmmere af disse isoenzymer vardenafilclearance.
English: When nitric oxide is released in response to sexual stimulation, inhibition of PDE5 by vardenafil results in increased corpus cavernosum levels of cGMP.
Danish: Når nitrogenoxid frigives som respons på seksuel stimulation, fører vardenafils hæmning af PDE5 til øgede cGMP-niveauer i corpus cavernosum.
English: A single dose, double blind, crossover, randomised trial in 59 healthy males compared the effects on the QT interval of vardenafil (10 mg and 80 mg), sildenafil (50 mg and 400 mg) and placebo.
Danish: Et enkeltdosis, dobbelt-blindt, cross-over, randomiseret studie med 59 raske mænd sammenlignede effekten på QT-intervallet mellem vardenafil (10 mg og 80 mg), sildenafil (50 mg og 400 mg) og placebo.
English: A starting dose of 5 mg should be considered in patients with mild and moderate hepatic impairment (Child-Pugh A-B).
Danish: En startdosis på 5 mg bør overvejes hos patienter med let og moderat nedsat leverfunktion (ChildPugh A-B).
English: At tmax, only the mean change in QTcF for vardenafil 80 mg was out of the study established limit (mean 10 msec, 90% CI: 8-11).
Danish: Ved tmax var kun ændringen i middelværdi for QTcF for 80 mg vardenafil udenfor den i studiet fastsatte grænse (middelværdi 10 msek, 90% CI: 811).
English: There is no safety information available on the administration of vardenafil to patients with bleeding disorders or active peptic ulceration.
Danish: Der findes ingen oplysninger om sikkerhed ved indgift af vardenafil hos patienter med blødningsforstyrrelser eller aktivt peptisk mavesår.
English: When vardenafil was administered in higher doses and more frequently than the recommended dose regimen (40 mg film-coated tablets twice daily) cases of severe back pain have been reported.
Danish: Ved indgift af vardenafil i højere doser og hyppigere end anbefalet (40 mg filmovertrukne tabletter 2 gange dagligt) blev der rapporteret stærke rygsmerter.
English: Levitra is not intended for use by children or adolescents under 18.
Danish: Levitra er ikke beregnet til børn og unge under 18 år.
English: 51368 Leverkusen Germany
Danish: 51368 Leverkusen
English: No clinical trials in CNS diseases (except spinal cord injury), patients with severe renal or hepatic impairment, pelvic surgery (except nerve-sparing prostatectomy) or trauma or radiotherapy and hypoactive sexual desire or penile anatomic deformities have been performed.
Danish: Der er ikke foretaget kliniske studier med patienter med CNSsygdomme (undtagen rygmarvsskader), stærkt nedsat nyre- eller leverfunktion, bækken kirurgi (med undtagelse af nervebesparende prostatektomi) eller trauma eller strålebehandling og hypoaktiv seksuel lyst eller anatomiske penisdeformationer.
English: In the predefined subgroups 57% (elderly patients), 56% (patients with history of diabetes mellitus), 59% (patients with history of dyslipidemia) and 60% (patients with history of hypertension) of all reported attempts with vardenafil 10 mg orodispersible tablets were successful in terms of maintenance of erection.
Danish: I de prædefinerede undergrupper var 57% (ældre patienter), 56% (patienter med diabetes mellitus i anamnesen), 59% (patienter med dyslipidæmi i anamnesen) og 60% (patienter med hypertension i anamnesen) af alle registrerede studier med vardenafil 10 mg smeltetabletter succesfulde med hensyn til vedligeholdelse af erektion.
English: White round tablets.
Danish: Hvid, rund tablet.
English: In a separate post-marketing study of 44 healthy volunteers, single doses of 10 mg vardenafil or 50 mg sildenafil were co-administered concomitantly with 400 mg gatifloxacin, a drug with comparable QT effect.
Danish: I et separate studie efter markedsføringen på 44 raske frivillige blev enkeltdoser på 10 mg vardenafil eller 50 mg sildenafil givet samtidig med 400 mg gatifloxacin, som er et lægemiddel med sammenlignelig QT-effekt.
English: If you experience sudden decrease or loss of vision, stop taking Levitra and contact your doctor immediately.
Danish: Hvis De oplever pludselige nedsættelser af synet eller tab af synet, skal De stoppe med at tage Levitra og straks søge læge.
English: Bioequivalence studies have shown that vardenafil 10 mg orodispersible tablet is not bioequivalent to vardenafil 10 mg film-coated tablets.
Danish: Bioækvivalensundersøgelser har vist, at vardenafil 10 mg smeltetablet ikke er bioækvivalent med vardenafil 10 mg filmovertrukne tabletter.
English: Vardenafil pharmacokinetics has not been studied in patients requiring dialysis (see section 4.3).
Danish: Farmakokinetikken af vardenafil er ikke undersøgt hos patienter med behov for dialyse (Se pkt.
English: When used in combination with the CYP3A4 inhibitors such as erythromycin or clarithromycin, the dose of vardenafil should not exceed 5 mg (see section 4.5).
Danish: Ved anvendelse i kombination med CYP3A4-inhibitorer som f.eks. erythromycin eller clarithromycin bør dosis af vardenafil ikke overskride 5 mg (se pkt.
English: The pharmacokinetics of vardenafil (20 mg) was not affected by co-administration with the H2-antagonist ranitidine (150 mg twice daily), digoxin, warfarin, glibenclamide, alcohol (mean maximum blood alcohol level of 73 mg/dl) or single doses of antacid (magnesium hydroxide/aluminium hydroxide).
Danish: Farmakokinetikken af vardenafil (20 mg) blev ikke påvirket af samtidig indgift af H2-antagonisten ranitidin (150 mg 2 gange dagligt), digoxin, warfarin, glibenclamid, alkohol (gennemsnitligt maksimalt niveau på 73 mg/dl alkohol i blodet), eller enkeltdoser af antacida (magnesiumhydroxid/aluminiumhydroxid).
English: Serious cardiovascular events including sudden death, tachycardia, myocardial infarction, ventricular tachy-arrythmia, angina pectoris, and cerebrovascular disorders (including transient ischaemic attack and cerebral haemorrhage), have been reported in temporal association with vardenafil.
Danish: Alvorlige kardiovaskulære hændelser såsom pludselig død, takykardi, myokardieinfarkt, ventrikulær takyarrytmi, angina pectoris og cerebrovaskulære lidelser (inklusive forbigående iskæmisk tilfælde og cerebral blødning) har været rapporteret i tidsmæssig relation til vardenafil.
English: The response rates for the ability to obtain and maintain an erection were 76% and 59% on vardenafil compared to 41% and 22% on placebo for patients who completed three months treatment which were clinically and statistically significant (p<0.001).
Danish: Responsraterne for evnen til at opnå og vedligeholde en erektion var 76% og 59% for vardenafil sammenlignet med 41% og 22% for placebo for patienter som gennemførte tre måneders behandling, hvilket var klinisk og statistisk signifikant (p<0,001).
English: In pooled data from the major efficacy trials, the proportion of patients experiencing successful penetration on vardenafil were as follows: psychogenic erectile dysfunction (77-87%), mixed erectile dysfunction (69-83%), organic erectile dysfunction (64-75%), elderly (52-75%), ischaemic heart disease (70-73%), hyperlipidaemia (62-73%), chronic pulmonary disease (74-78%), depression (59-69%), and patients concomitantly treated with antihypertensives (62-73%).
Danish: I poolede data fra de større effektivitetsstudier var andelen af patienter, som opnåede succesfuld penetration vha. vardenafil: Psykogen erektil dysfunktion (77-87%), kombineret erektil dysfunktion, (69-83%), organisk erektil dysfunktion ( 64-75%), ældre (52-75%), iskæmisk hjertesygdom (70-73%) hyperlipædemi (62-73%), kronisk lungesygdom (74-78%), depression (59-69%) og patienter som samtidigt blev behandlet med antihypertensiva (62-73%).
English: The co-administration of PDE5 inhibitors, including vardenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension (see section
Danish: Samtidig administration af PDE5-hæmmere, herunder vardenafil, med guanylatcyklase-stimulatorer som f.eks. riociguat, er kontraindiceret, da det kan føre til symptomatisk hypotension (se pkt.
English: Hypromellose Titanium dioxide (E171) Ferric oxide yellow (E172) Ferric oxide red (E172)
Danish: Hypromellose Titandioxid (E171) Gul jernoxid (E172) Rød jernoxid (E172)
English: Adverse reactions are listed according to the MedDRA frequency convention: very common (≥1/10),
Danish: Tabel over bivirkninger Bivirkningerne er opført med frekvenser i henhold til MedDRA-konventionen: Meget almindelig
English: (≥1/10,000 to
Danish: (≥1/10.000 til,
English: Levitra 10 mg orodispersible tablets contain Aspartame and Sorbitol.
Danish: Levitra 10 mg smeltetabletter indeholder aspartam og sorbitol:
English: - If you are taking ritonavir or indinavir, medicines used to treat human immunodeficiency virus (HIV) infections.
Danish: - Hvis De tager ritonavir eller indinavir, medicin mod human immundefekt virusinfektion (hiv).
English: As this may be relevant for all patients exposed to vardenafil the patient should be advised that in the case of sudden visual defect, he should stop taking Levitra and consult immediately a physician (see section 4.3).
Danish: Da dette kan være relevant for alle patienter, som eksponeres for vardenafil, skal patienten informeres om, at han skal stoppe med at tage Levitra og omgående konsultere en læge, hvis der pludseligt opstår synsdefekt (se pkt.
English: A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered.
Danish: Før farmakologisk behandling påbegyndes bør der optages anamnese og foretages fysisk undersøgelse for at diagnosticere erektil dysfunktion og undersøge potentielle underliggende årsager.
English: Penile haemorrhage, haematospermia and haematuria have been reported in clinical trials and spontaneous post-marketing data with the use of all PDE5 inhibitors, including vardenafil.
Danish: Blødning fra penis, hæmospermi og hæmaturi er blevet rapporteret i kliniske studier og spontane data efter markedsføring ved behandling med alle PDE5-hæmmere, herunder vardenafil.
English: Based on tolerability and efficacy, the dose may be increased to Levitra 10 mg and 20 mg film-coated tablets, or Levitra 10 mg orodispersible tablets.
Danish: Vurderet ud fra tolerance og effekt kan dosis øges til Levitra 10 mg og 20 mg filmovertrukne tabletter eller Levitra 10 mg smeltetabletter.
English: In patients with severe renal impairment (creatinine clearance <30 ml/min), a starting dose of 5 mg should be considered.
Danish: Hos patienter med stærk nedsat nyrefunktion (kreatininclearance < 30 ml/min) bør en startdosis på 5 mg overvejes.
English: When vardenafil (20 mg film-coated tablets) and alcohol (mean maximum blood alcohol level of 73 mg/dl) were taken together, vardenafil did not potentiate the effects of alcohol on blood pressure and heart rate and the pharmacokinetics of vardenafil were not altered.
Danish: Ved samtidig indgift af vardenafil (20 mg filmovertrukne tabletter) og alkohol (gennemsnitligt maksimalt niveau på 73 mg/dl alkohol i blodet) forstærkede vardenafil ikke effekten af alkohol på blodtryk og hjertefrekvens, og vardenafils farmakokinetik forblev uændret.
English: Patients treated with alpha-blockers should not use Levitra 10 mg orodispersible tablets as a starting dose.
Danish: Patienter, der bliver behandlet med alfa-blokker, bør ikke anvende Levitra 10 mg smeltetabletter som startdosis.
English: - Ketoconazole or itraconazole, anti-fungal medicines.
Danish: - Ketoconazol eller itraconazol, anti-svampemidler.