FrancophonIA/ELRC3.0 huggingface dataset:
English: Efavirenz must not be administered with elbasvir/grazoprevir due to the expected significant decreases in elbasvir and grazoprevir plasma concentrations caused by induction of drug metabolising enzymes and/or transport proteins and which are expected to result in the loss of virologic response of elbasvir/grazoprevir (see section 4.5).
Danish: Efavirenz må ikke administreres sammen med elbasvir/grazoprevir på grund af de forventede signifikante fald i plasmakoncentrationen af elbasvir og grazoprevir som følge af induktion af lægemiddelmetaboliserende enzymer og/eller transportproteiner og som forventes at medføre tab af virologisk respons på elbasvir/grazoprevir (se pkt.
English: Grapefruit juice should be avoided when taking Stocrin.
Danish: Undlad at drikke grapefrugtjuice, når du tager Stocrin.
English: Rash was reported more frequently in children (in a clinical study including 57 children who received efavirenz during a 48-week period, rash was reported in 46 %) and was more often of higher grade than in adults (severe rash was reported in 5.3 % of children).
Danish: Der rapporteredes oftere om udslæt hos børn (i en klinisk undersøgelse, der omfattede 57 børn, som fik efavirenz i en periode på 48 uger, blev der rapporteret om udslæt hos 46%) og var oftere mere omfattende end hos voksne (alvorligt udslæt blev rapporteret hos 5,3% af børnene).
English: Contact your doctor or pharmacist for advice.
Danish: Spørg din læge eller apotekspersonalet om råd.
English: Among co-infected patients in study 006, elevations in AST to greater than five times ULN developed in 13 % of efavirenz treated patients and in 7 % of controls, and elevations in ALT to greater than five times ULN developed in 20 % and 7 % respectively.
Danish: Blandt co-inficerede patienter i undersøgelse 006 steg ASAT mere end fem gange ULN hos 13% af de patienter, der fik efavirenz, og hos 7% af patienterne i kontrolgruppen, og ALAT steg mere end fem gange ULN hos henholdsvis 20% og 7%.
English: The dose of nelfinavir was 750 mg given three times a day.
Danish: Nelfinavirdosis var 750 mg 3 gange daglig.
English: The recommended dose of efavirenz in combination with a PI and/or NRTIs for patients between 3 and 17 years of age is described in Table 1.
Danish: Den anbefalede dosis af efavirenz i kombination med en PI'er og/eller NRTI'ere til patienter i alderen 3-17 år er anført i tabel 1.
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Danish: kronisk aktiv hepatitis har øget frekvens af leverfunktionsabnormaliteter under antiretroviral kombinationsbehandling og bør monitoreres i henhold til gældende praksis.
English: maraviroc the combination tablet containing efavirenz, emtricitabine and tenofovir should not be taken with Stocrin unless recommended by your doctor since it contains efavirenz, the active ingredient of Stocrin.
Danish: maraviroc kombinationstabletten, der indeholder efavirenz, emtricitabin og tenofovir må ikke tages sammen med Stocrin, medmindre din læge anbefaler det, da den indeholder efavirenz, der er det aktive stof i Stocrin.
English: If efavirenz and telaprevir are coadministered, telaprevir 1,125 mg every 8 hours should be used.
Danish: Hvis efavirenz og telaprevir administreres samtidigt, skal der gives telaprevir 1,125 mg hver 8. time.
English: IMMUNOSUPPRESSANTS Immunosuppressants metabolized by CYP3A4 (e.g., cyclosporine, tacrolimus, sirolimus)/Efavirenz
Danish: IMMUNOSUPPRESIVA Immunsuppressiva metaboliseres via CYP3A4 (fx ciclosporin, tacrolimus, sirolimus)/efavirenz
English: Immunosuppressants such as cyclosporine, sirolimus, or tacrolimus (medicines used to prevent organ transplant rejection): when you start or stop taking Stocrin, your doctor will closely monitor your plasma levels of the immunosuppressant and may need to adjust its dose.
Danish: • Immunsuppressive lægemidler såsom ciclosporin, sirolimus eller tacrolimus (medicin til at forhindre afstødelse af organer efter transplantation): når du starter eller stopper med at tage Stocrin vil lægen kontrollere indholdet af det immunsuppressive lægemiddel i blodet, og det kan være nødvendigt at justere dosis.
English: AUC: ↑ 17 % (↑ 6 to ↑ 29) ** Cmax: ↔** *compared to 200 mg twice daily alone ** compared to 600 mg once daily alone (competitive inhibition of oxidative metabolism)
Danish: AUC: ↑ 17 % (↑ 6 til ↑ 29)** Cmax: ↔** *sammenlignet med 200 mg alene to gange dagligt **sammenlignet med 600 mg alene én gang dagligt (kompetitiv hæmning af oxidativ metabolisme)
English: Talk to you doctor before taking Stocrin
Danish: Kontakt lægen, før du tager Stocrin.
English: When efavirenz is co-administered with an anticonvulsant that is a substrate of CYP450 isoenzymes, periodic monitoring of anticonvulsant levels should be conducted.
Danish: Når efavirenz administreres sammen med et antikonvulsivum, som er et substrat for CYPisoenzymer, bør regelmæssig monitorering af antikonvulsivakoncentrationen foretages.
English: Carcinogenicity studies showed an increased incidence of hepatic and pulmonary tumours in female mice, but not in male mice.
Danish: Karcinogenecitetsundersøgelser har vist øget incidens af hepatiske og pulmonære tumorer hos hunmus, men ikke hos hanmus.
English: Film coating: Hypromellose (E464), Titanium dioxide (E171), Macrogol 400, Yellow iron oxide (E172), Carnauba wax
Danish: Filmovertræk: Hypromellose (E464), titandioxid (E171), macrogol 400, gul jernoxid (E172), carnaubavoks
English: Medicines used to lower blood fats (also called statins):atorvastatin, pravastatin, simvastatin.
Danish: • Medicin til at mindske fedt i blodet (også kaldet statiner): atorvastatin, pravastatin, simvastatin.
English: • The film coating contains: hypromellose (E464), titanium dioxide (E171), macrogol 400, yellow iron oxide (E172), and carnauba wax.
Danish: • Filmovertrækket indeholder: Hypromellose (E464), titandioxid (E171), macrogol 400, gul jernoxid (E172) og carnaubavoks.
English: Decreased exposure of etonogestrel may be expected (CYP3A4 induction).
Danish: Der kan forventes nedsat eksponering for etonogestrel (CYP3A4-induktion).
English: Viral isolates recovered from PBMCs of patients enrolled in efavirenz clinical studies who showed evidence of treatment failure (viral load rebound) were assessed for susceptibility to NNRTIs.
Danish: Virale isolater, der er indhentet fra PBMCer fra patienter, der var inkluderet i kliniske efavirenzundersøgelser, som viste tegn på behandlingssvigt (reboundfænomen af virus i blodet) blev vurderet med henblik på følsomhed over for NNRTI'ere.
English: Co-administration of STOCRIN with sofosbuvir/velpatasvir or sofosbuvir/velpatasvir/voxilaprevir is not recommended (refer to the Summary of Product Characteristics for sofosbuvir/velpatasvir and sofosbuvir/velpatasvir/voxilaprevir for additional information).
Danish: Samtidig administration af STOCRIN og sofosbuvir/velpatasvir eller sofosbuvir/velpatasvir/ voxilaprevir frarådes (se produktresuméerne for sofosbuvir/velpatasvir og sofosbuvir/velpatasvir/ voxilaprevir for yderligere oplysninger).
English: In 17 paediatric patients receiving an investigational oral solution similar to the commercial formulation adjusted on the basis of body size to be equivalent to an adult 600 mg capsule dose, the steady-state Cmax was 11.8 M, steady state Cmin was 5.2 M, and AUC was 188 M·h.
Danish: Hos 17 pædiatriske patienter, som fik en test oral opløsning svarende til den formulering, der markedsføres og justeret på basis af legemsstørrelse til at svare til en 600 mg kapsel dosis til voksne, var steady-state Cmax 11,8 M, steady-state Cmin var 5,2 M og AUC var 188 Mt.
English: Paediatric population: ACTG 382 is an ongoing uncontrolled study of 57 NRTI-experienced paediatric patients (3 - 16 years) which characterises the pharmacokinetics, antiviral activity and safety of efavirenz in combination with nelfinavir (20 - 30 mg/kg given three times a day) and one or more NRTIs.
Danish: Pædiatrisk population: ACTG 382 er en igangværende ukontrolleret undersøgelse af 57 NRTIbehandlede, pædiatriske patienter (3 - 16 år), som beskriver farmakokinetik, antiviral aktivitet og sikkerhed af efavirenz i kombination med nelfinavir (20 - 30 mg/kg indgivet 3 gange om dagen) og et eller flere NRTI'ere.
English: • The other ingredients of the tablet core are: croscarmellose sodium, microcrystalline cellulose,
Danish: • Øvrige indholdsstoffer i tabletkernen: Croscarmellosenatrium, mikrokrystallinsk cellulose,
English: Each ml contains 30 mg of efavirenz.
Danish: Hver ml indeholder 30 mg efavirenz.
English: Diltiazem or similar medicines (called calcium channel blockers which are medicines typically used for high blood pressure or heart problems): when you start taking Stocrin, your doctor may need to adjust your dose of the calcium channel blocker.
Danish: • Diltiazem eller lignende medicin (kaldet calciumantagonister, som er lægemidler, der typisk anvendes til behandling af højt blodtryk eller hjerteproblemer): når du starter med at tage Stocrin, kan lægen være nødt til at justere dosis af en calciumantagonist.
English: AUC: ↑ 20 % (↑ 8 to ↑ 34) Cmax: ↑ 21 % (↑ 10 to ↑ 33) The combination was generally well tolerated.
Danish: AUC: ↑ 20 % (↑ 8 til ↑ 34) Cmax: ↑ 21 % (↑ 10 til ↑ 33) Kombinationen var generelt veltolereret.
English: Reported rates of recurrent rash following a switch from nevirapine to efavirenz therapy, primarily based on retrospective cohort data from published literature, range from 13 to 18 %, comparable to the rate observed in patients treated with efavirenz in clinical studies.
Danish: Hyppigheden af tilbagevendende udslæt efter skift fra behandling med nevirapin til efavirenz, varierer fra 13 til 18% (primært baseret på retrospektive kohortedata fra publiceret litteratur), hvilket svarer til hyppigheden hos patienter, der er blevet behandlet med efavirenz i kliniske undersøgelser (se pkt.
English: STOCRIN 50 mg film-coated tablets Yellow, round, debossed with “113” on one side.
Danish: STOCRIN 50 mg filmovertrukne tabletter Gule, runde, præget med “113” på den ene side.
English: The recommended dose of efavirenz oral solution in combination with a PI and/or NRTIs for patients between 3 and 17 years of age is described in Table 1.
Danish: Den anbefalede dosis af efavirenz oral opløsning i kombination med en PI'er og/eller NRTI'ere til patienter i alderen 3-17 år er anført i tabel 1.
English: AUC: ↑ 7 % (↑ 1 to ↑ 14) Cmax: ↑ 16 % (↑ 2 to ↑ 32) These changes are not considered clinically significant.
Danish: AUC: ↑ 7% (↑ 1 til ↑ 14) Cmax: ↑ 16% (↑ 2 til ↑ 32) Disse forandringer anses ikke for at være klinisk signifikante.
English: Among co-infected patients, 3 % of those treated with efavirenz and 2 % in the control arm discontinued because of liver disorders (see section 4.4).
Danish: Blandt de co-inficerede patienter stoppede 3% i efavirenz-gruppen og 2% i kontrolgruppen på grund af leversygdom (se pkt.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral agents have a higher risk for severe and potentially life-threatening liver problems.
Danish: Patienter med kronisk hepatitis B eller C (leverbetændelse), som er i kombinationsbehandling med antiretrovirale lægemidler, har en højere risiko for alvorlige og muligvis livstruende leverproblemer.
English: 13 to < 15 15 to < 20 20 to < 25 25 to < 32.5 32.5 to < 40  Stocrin 50 mg, 200 mg and 600 mg film-coated tablets are available.
Danish: 13 til  15 15 til  20 20 til  25 25 til  32,5 32,5 til  40 * Stocrin kan fås som 50 mg, 200 mg og 600 mg filmovertrukne tabletter.
English: Outer carton: STOCRIN 30 mg/ml
Danish: Ydre pakning: STOCRIN 30 mg/ml
English: Herbal preparations containing St. John's wort (Hypericum perforatum) due to the risk of decreased plasma concentrations and reduced clinical effects of efavirenz (see section 4.5).
Danish: Naturlægemidler, som indeholder prikbladet perikum (Hypericum perforatum), på grund af risiko for reduktion i plasmakoncentrationer samt reduceret klinisk effekt af efavirenz (se pkt.
English: • With the bottle upright, fit the tip of the syringe into the bottle adapter.
Danish: • Med flasken på højkant placeres spidsen af sprøjten i flaskeadapteren.
English: Compounds or herbal preparations (for example Ginkgo biloba extracts and St. John's wort) which induce these enzymes may give rise to decreased plasma concentrations of efavirenz.
Danish: Lægemiddelstoffer eller naturlægemidler (fx Ginkgo biloba og perikon), der inducerer disse enzymer, kan medføre nedsat plasmakoncentration af efavirenz.
English: When using efavirenz with low-dose ritonavir, the possibility of an increase in the incidence of efavirenz-associated adverse events should be considered, due to possible pharmacodynamic interaction.
Danish: Når efavirenz gives sammen med ritonavir i lav dosis, bør muligheden for stigning i incidensen af efavirenzassocierede bivirkninger overvejes på grund af eventuel farmakodynamisk interaktion.
English: In 49 paediatric patients receiving the equivalent of a 600 mg dose of efavirenz (dose adjusted from calculated body size based on weight), steady state Cmax was 14.1 M, steady state Cmin was 5.6 M, and AUC was 216 M·h.
Danish: Hos 49 pædiatriske patienter, der fik en dosis ækvivalent med 600 mg efavirenz (dosis justeret ud fra beregnet legemsstørrelse på basis af vægt) var steady-state Cmax 14,1 M, steady-state Cmin 5,6 M og AUC 216 Mt.
English: Other medicines and Stocrin
Danish: Brug af anden medicin sammen med Stocrin
English: Evidence exists indicating that efavirenz may have altered pharmacokinetics in very young children.
Danish: Det tyder på, at efavirenz' farmakokinetik kan være anderledes hos meget små børn.
English: The adapter should now fit closely to the neck so that the cap can be replaced without removing it.
Danish: Adapteren bør nu sidde helt til inde i flaskens hals, således at låget kan sættes på flasken igen, uden at adapteren først må fjernes.
English: In these studies, efavirenz did not impair mating or fertility of male or female rats (doses up to 100 mg/kg/bid), and did not affect sperm or offspring of treated male rats (doses up to 200 mg/bid).
Danish: I disse undersøgelser hæmmede efavirenz ikke parring eller fertilitet hos han- eller hunrotter (doser op til 100 mg/kg/to gange dagligt), og påvirkede ikke de behandlede hanrotters sperma eller afkom (doser op til 200 mg/to gange dagligt).
English:  Efavirenz 50 mg, 200 mg and 600 mg film-coated tablets are available.
Danish: *Efavirenz findes som 50 mg, 200 mg og 600 mg filmovertrukne tabletter.
English: Methadone(a medicine used to treat opiate addiction):your doctor may recommend an alternative treatment.
Danish: • Methadon (medicin til behandling af opioidmisbrug): lægen vil måske tilråde en anden behandling.
English: Medicines used to treat convulsions/seizures (anticonvulsants): carbamazepine, phenytoin, phenobarbital.
Danish: • Medicin til behandling af krampeanfald: carbamazepin, phenytoin, phenobarbital.
English: AUC: ↓ 51% Cmax: ↓ 21% Dihydroartemisinin: AUC: ↓ 46% Cmax: ↓ 38% Lumefantrine:
Danish: AUC: ↓ 51 % Cmax: ↓ 21 % Dihydroartemisinin: AUC: ↓ 46 % Cmax: ↓ 38 % Lumefantrin:
English: Severe rash occurred in less than 1 % of patients treated with efavirenz, and 1.7 % discontinued therapy because of rash.
Danish: Svært udslæt optrådte hos færre end 1% af de efavirenzbehandlede patienter, og 1,7% ophørte med behandlingen på grund af udslæt.
English: Sertraline(a medicine used to treat depression):your doctor may need to change your dose of sertraline.
Danish: • Sertralin (medicin til behandling af depression): lægen vil måske være nødt til at ændre din sertralindosis.
English: • The dose for adults is 24 ml once daily.
Danish: • Dosis til voksne er 24 ml 1 gang dagligt.
English: AUC: ↑ 11 % (↑ 5 to ↑ 18) Cmax: ↑ 16 % (↑ 6 to ↑ 26) Cmin: ↑ 13 % (↑ 1 to ↑ 26) (CYP3A4 induction) The increase in efavirenz pharmacokinetic parameters is not considered clinically significant.
Danish: AUC: ↑ 11% (↑ 5 til ↑ 18) Cmax: ↑ 16% (↑ 6 til ↑ 26) Cmin: ↑ 13% (↑ 1 til ↑ 26) (CYP3A4-induktion) Stigningen i efavirenz' farmakokinetiske parametre anses ikke for at være klinisk signifikant.
English: In uninfected volunteers, multiple doses of 200 - 400 mg per day for 10 days resulted in a lower than predicted extent of accumulation
Danish: Hos ikke-inficerede frivillige resulterede multiple doser på 200 - 400 mg per dag i 10 dage i en lavere grad af akkumulation (2242% lavere) end forudset samt kortere halveringstid sammenlignet med enkeltdosisadministration (se nedenfor).
English: General disorders and administration site conditions common fatigue
Danish: Almene symptomer og reaktioner på administrationsstedet Almindelig
English: • The dose for adults is 600 mg once daily.
Danish: • Dosis til voksne er 600 mg 1 gang dagligt.
English: Liver enzymes: elevations of AST and ALT to greater than five times the upper limit of the normal range (ULN) were seen in 3 % of 1,008 patients treated with 600 mg of efavirenz (5-8 % after longterm treatment in study 006).
Danish: Leverenzymer: Der sås forhøjelser af ASAT og ALAT til mere end 5 gange den øvre grænse for normalområdet (ULN) hos 3% af 1.008 patienter, der blev behandlet med 600 mg efavirenz (5-8% efter langtidsbehandling i Undersøgelse 006).
English: • if you are currently taking any of the following medicines (see also “Other medicines and Stocrin”): - astemizole or terfenadine (used to treat allergy symptoms)
Danish: • hvis du samtidigt tager et eller flere af følgende lægemidler (se også ”Brug af anden medicin sammen med Stocrin”):
English: • The other ingredients are: medium chain triglycerides, benzoic acid (E210) and strawberry/mint flavour.
Danish: • Øvrige indholdsstoffer: Middellængde triglycerider, benzoesyre (E210) og jordbær/mintsmag.
English: Cmax: ↑ 11 % (↑ 3 to ↑ 19) (CYP3A4 induction) Rash developed in 46 % of uninfected volunteers receiving efavirenz and clarithromycin.
Danish: Cmax: ↑ 11 % (↑ 3 til ↑ 19) (CYP3A4-induktion) Udslæt forekom hos 46% af de ikke-inficerede frivillige, der fik efavirenz og clarithromycin.
English: If you notice any of these symptoms please inform your doctor.
Danish: Hvis du bemærker et eller flere af disse symptomer, skal du fortælle det til din læge.
English: Efavirenz oral solution (30 mg/ml)
Danish: Efavirenz oral opløsning (30 mg/ml)
English: STOCRIN 200 mg film-coated tablets Yellow, round, debossed with “223” on one side.
Danish: STOCRIN 200 mg filmovertrukne tabletter Gule, runde, præget med “223” på den ene side.
English: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Danish: Overfølsomhed over for det aktive indholdsstof eller et af hjælpestofferne anført i pkt.
English: Stocrin contains lactose in each 600-mg daily dose.
Danish: Stocrin indeholder lactose i hver 600 mg dosis.
English: (500/125 mg twice daily/600 mg once daily)
Danish: (500/125 mg to gange dagligt/600 mg én gang dagligt)
English: 180 ml oral solution Oral syringe with a pushin bottleneck adapter.
Danish: 180 ml oral opløsning Oral sprøjte med adapter til at sætte i flaskens hals.
English: sodium laurilsulfate, hydroxypropylcellulose, lactose monohydrate and magnesium stearate.
Danish: natriumlaurilsulfat, hydroxypropylcellulose, lactosemonohydrat og magnesiumstearat.
English: Do not use this medicine after the expiry date which is stated on the bottle and on the carton after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på flasken og på pakningen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: HDPE bottles with a child-resistant polypropylene closure containing 180 ml of oral solution.
Danish: HDPE-flasker med børnesikret polypropylenlåg indeholdende180 ml oral opløsning.
English: Medicines used to treat infection with the hepatitis C virus: boceprevir, telaprevir, simeprevir, sofosbuvir/velpatasvir, glecaprevir/pibrentasvir and sofosbuvir/velpatasvir/voxilaprevir.
Danish: • Medicin til behandling af infektion med hepatitis C-virus: boceprevir, telaprevir, simeprevir, sofosbuvir/velpatasvir, glecaprevir/pibrentasvir og sofosbuvir/velpatasvir/voxilaprevir.
English: • The dose for children weighing 40 kg or more is 600 mg once daily.
Danish: • Dosis til børn, der vejer 40 kg eller mere, er 600 mg 1 gang dagligt.
English: Artemether/lumefantrine/ Efavirenz (20/120 mg tablet, 6 doses of 4 tablets each over 3 days/600 mg once daily)
Danish: Artemether/lumefantrin/efavirenz (20/120 mg tablet, 6 doser af 4 tabletter over 3 dage/600 mg en gang dagligt)
English: Pregnancies have occurred in women taking Stocrin while using a contraceptive implant, although it has not been established that the Stocrin therapy caused the contraceptive to fail.
Danish: Graviditet kan forekomme hos kvinder, der tager Stocrin, mens de bruger et kontraceptivt implantat, selvom det ikke er fastslået, at behandling med Stocrin har bevirket, at det kontraceptive middel ikke virkede.
English: • The dose for children weighing 40 kg or more is 24 ml once daily.
Danish: • Dosis til børn, der vejer 40 kg eller mere, er 24 ml 1 gang dagligt.
English: EFV +
Danish: EFV + IDV
English: The pharmacokinetics of efavirenz have not been studied in patients with renal insufficiency; however, less than 1 % of an efavirenz dose is excreted unchanged in the urine, so the impact of renal impairment on efavirenz elimination should be minimal (see section 4.2).
Danish: Efavirenz' farmakokinetik er ikke undersøgt hos patienter med nyreinsufficiens; mindre end 1% af en efavirenzdosis udskilles imidlertid uomdannet i urinen, så indvirkningen af nyreinsufficiens på eliminationen af efavirenz bør være minimal (se pkt.
English: The long-term safety profile of efavirenz-containing regimens was evaluated in a controlled trial (006) in which patients received efavirenz + zidovudine + lamivudine (n = 412, median duration 180 weeks), efavirenz + indinavir (n = 415, median duration 102 weeks), or indinavir + zidovudine + lamivudine (n = 401, median duration 76 weeks).
Danish: Langtidssikkerhedsprofilen for regimer, der indeholder efavirenz blev evalueret i en kontrolleret undersøgelse (006), hvor patienter behandledes med enten efavirenz + zidovudin + lamivudin (n = 412, medianvarighed 180 uger), eller efavirenz + indinavir (n = 415, medianvarighed 102 uger) eller indinavir + zidovudin + lamivudin (n = 401, medianvarighed 76 uger).
English: The choice of new antiretroviral agent(s) to be used in combination with efavirenz should take into consideration the potential for viral cross-resistance (see section 5.1).
Danish: Ved valg af nyt antiretroviralt lægemiddel til anvendelse i kombination med efavirenz skal den potentielle, virale krydsresistens tages i betragtning (Se pkt.
English: Stocrin may reduce the amount of itraconazole in your blood.
Danish: Stocrin kan nedsætte mængden af itraconazol i blodet.
English: AUC: ↑ 34 % (↑ 18 to ↑ 53) Cmax: ↑ 49 % (↑ 32 to ↑ 69) Efavirenz:
Danish: AUC: ↑ 34 % (↑ 18 til ↑ 53) Cmax: ↑ 49 % (↑ 32 til ↑ 69) Efavirenz:
English: This loss is due to significant decreases in elbasvir and grazoprevir plasma concentrations caused by CYP3A4 or P-gp induction (refer to the Summary of Product Characteristics for elbasvir/grazoprevir for additional information).
Danish: Dette tab skyldes signifikante fald i plasmakoncentrationen af elbasvir og grazoprevir som følge af CYP3A4- eller P-gp-induktion (se produktresuméet for elbasvir/grazoprevir for yderligere oplysninger).
English: When prescribing medicinal products concomitantly with efavirenz, physicians should refer to the corresponding Summary of Product Characteristics.
Danish: Ved ordinering af medicin til brug sammen med efavirenz bør lægen rådføre sig med det pågældende produktresumé.
English: Women of childbearing potential should undergo pregnancy testing before initiation of efavirenz (see section 5.3).
Danish: Kvinder i den fertile alder skal have foretaget graviditetstest, før behandling med efavirenz initieres (se pkt.
English: What Stocrin contains
Danish: Stocrin indeholder:
English: Stocrin may reduce the amount of posaconazole in your blood.
Danish: Stocrin kan nedsætte mængden af posaconazol i blodet.