FrancophonIA/ELRC3.0 huggingface dataset:
English: The addition of bazedoxifene, acting as an oestrogen receptor antagonist in the uterus, greatly reduces the oestrogen-induced risk of endometrial hyperplasia in non-hysterectomised women.
Danish: Tilføjelsen af bazedoxifen, der fungerer som østrogenreceptor-antagonist i livmoderen, reducerer betydeligt den østrogen-inducerede risiko for endometriehyperplasi hos kvinder, der ikke har fået foretaget hysterektomi, betydeligt.
English: - A 2 to 4-fold increase in the risk of gallbladder disease requiring surgery in postmenopausal women receiving oestrogens has been reported (see section 4.8).
Danish: - Der er rapporteret en stigning på 2-4 gange i risikoen for galdeblæresygdom, der kræver operation hos postmenopausale kvinder, der fik østrogener (se pkt.
English: Little or no cytochrome P450-mediated metabolism is evident.
Danish: Der er påvist ringe eller ingen cytochrom P450-medieret metabolisme.
English: The observation of benign, ovarian granulosa-cell tumours in female mice and rats administered bazedoxifene is a class effect of SERMs related to its pharmacology in rodents when treated during their reproductive lives, when their ovaries are functional and responsive to hormonal stimulation.
Danish: De observerede benigne granulosacelletumorer i ovarierne hos hunmus og rotter, der fik bazedoxifen, er en klasseeffekt for selektive østrogenreceptormodulatorer, der er relateret til farmakologien hos gnavere ved behandling i den reproduktive del af deres liv, når deres ovarier fungerer og responderer på hormonel stimulering.
English: • Feeling nervous
Danish: • Følelse af nervøsitet
English: Female rats were administered daily dosages of 0.3 to 30 mg/kg (0.15 to 14.6 times the human dose based on body surface area, mg /m2 [20 mg/kg dosage in humans is 12.3 mg/m2]) prior to and during mating with untreated males.
Danish: Hunrotter fik daglige doser på 0,3-30 mg/kg (0,15-14,6 gange den humane eksponering baseret på overfladeareal, mg/m2 [en dosis på 20 mg/kg hos mennesker er 12,3 mg/m2]) før og under parring med ubehandlede hanrotter.
English: In studies conducted in rabbits, bazedoxifene alone has shown reproductive toxicity (see section 5.3).
Danish: I forsøg med kaniner, har bazedoxifen alene vist reproduktiv toksicitet (se pkt.
English: Additional cases per 1,000 ET users over 5 years (95%CI)
Danish: Yderligere tilfælde pr. 1.000 ET-brugere over 5 år (95 % CI)
English: The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce uridine diphosphate glucuronosyltransferases (UGTs), such as rifampicin, phenobarbital, carbamazepine, and phenytoin, potentially leading to decreased systemic concentrations of bazedoxifene.
Danish: Metabolismen af bazedoxifen kan forøges ved samtidig indtagelse af stoffer, som er kendt for at påvirke uridin-diphosphat-glukuronosyltransferaser (UGT-enzymer), såsom rifampicin, phenobarbital, carbamazepin og phenytoin, og kan muligvis føre til nedsatte systemiske koncentrationer af bazedoxifen.
English: Microcrystalline cellulose Powdered cellulose
Danish: Mikrokrystallinsk cellulose Cellulosepulver
English: What DUAVIVE contains
Danish: Duavive indeholder:
English: Studies in rats with bazedoxifene have shown adverse effects on fertility (see section 5.3).
Danish: Forsøg med bazedoxifen på rotter har vist bivirkninger vedrørende fertiliteten (se pkt.
English: Frequency of occurrence of adverse reactions
Danish: Hyppighed af bivirkningers forekomst
English: There is some evidence of increased risk of probable dementia in women who start using continuous oestrogen-only therapy after the age of 65.
Danish: Der er nogen evidens for en øget risiko for mulig demens hos kvinder, som påbegynder kontinuerlig behandling med østrogen alene efter 65 års-alderen.
English: UPVC/ Monochlorotrifluorethylene blister packs containing 28 modified-release tablets.
Danish: UPVC/monochlorotrifluorethylen-blisterpakninger med 28 tabletter med modificeret udløsning.
English: BZA was not genotoxic or mutagenic in a battery of tests, including in vitro bacterial reverse mutation assay, in vitro mammalian cell forward mutation assay at the thymidine kinase (TK/-) locus in L5178Y mouse lymphoma cells, in vitro chromosome aberration assay in Chinese hamster ovary (CHO) cells, and in vivo mouse micronucleus assay.
Danish: Bazedoxifen var ikke genotoksisk eller mutagent i en række test, herunder bakteriel omvendt mutationsanalyse in vitro, fremadrettet mutationsanalyse in vitro med celler fra pattedyr på thymidinkinase (TK±) locus i L5178Y-lymfomceller fra mus, kromosom-aberrationsanalyse in vitro på ovarieceller fra kinesisk hamster (CHO), og mikronukleusanalyse in vivo på mus.
English: CE are soluble in water and are well-absorbed from the gastrointestinal tract after release from the medicinal product formulation.
Danish: Konjugerede østrogener er vandopløselige og absorberes godt fra mavetarmkanalen efter frigivelse fra lægemiddelformuleringen.
English: Bazedoxifene undergoes little or no cytochrome P450 (CYP)-mediated metabolism.
Danish: Bazedoxifen undergår kun ringe eller ingen cytochrom P450 (CYP-medieret) metabolisme.
English: CE/BZA may be taken at any time of day, without regard to meals (see section 5.2).
Danish: Konjugerede østrogener/bazedoxifen kan tages på et hvilket som helst tidspunkt af dagen, uden hensyn til måltider (se pkt.
English: The overall evidence suggests a possible increased risk of breast cancer in women taking oestrogen-only therapy that is dependent on the duration of therapy.
Danish: Den generelle evidens tyder på en mulig øget risiko for brystcancer hos kvinder, der er i behandling med østrogen alene, og at denne risiko er afhængig af behandlingsvarigheden.
English: • A worsening of asthma
Danish: • Forværring af astma
English: • changes in the nipple
Danish: • forandringer i brystvorten
English: For women in their 50s who are taking HRT, there will be 11 cases in 1,000 users, over 5 years (i.e., 3 extra cases).
Danish: For kvinder i 50'erne, som tager HRT, vil der være 11 tilfælde blandt 1.000 brugere over en periode på 5 år (det vil sige 3 yderligere tilfælde).
English: In case of doubt, talk to your doctor before you take this medicine.
Danish: Hvis du er i tvivl, skal du tale med lægen, før du tager dette lægemiddel.
English: Ovarian cancer is rare-much rarer than breast cancer.
Danish: Ovariecancer forekommer langt sjældnere end brystcancer.
English: CE/BZA is only for use in postmenopausal women, and is contraindicated in women who are or may become pregnant (see section 4.3).
Danish: Konjugerede østrogener/bazedoxifen er kun til brug hos postmenopausale kvinder og er kontraindiceret hos kvinder, der er eller kan blive gravide (se pkt.
English: For women with a history of cholestatic jaundice associated with past oestrogen use or with pregnancy, caution should be exercised, and in the case of recurrence, CE/BZA should be discontinued.
Danish: Der bør udvises forsigtighed hos kvinder med cholestatisk gulsot i anamnesen i forbindelse med tidligere brug af østrogen eller i forbindelse med graviditet, og i tilfælde af recidiv, bør konjugerede østrogener/bazedoxifen seponeres.
English: Systemic exposure (AUC) of bazedoxifene in these groups was 2.6 and 6.6 times that observed in postmenopausal women administered 20 mg/day for 14 days.
Danish: Den systemiske eksponering (AUC) for bazedoxifen hos disse grupper var 2,6 og 6,6 gange større end eksponeringen hos postmenopausale kvinder, der fik 20 mg/dag i 14 dage.
English: Patients with rare hereditary problems of galactose intolerance, total lactase deficiency, fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicinal product.
Danish: Dette lægemiddel bør ikke anvendes til patienter med hereditær galactoseintolerans, total lactasemangel, fructoseintolerans, glucose/galactosemalabsorption eller sucrase-isomaltasemangel.
English: • migraine-like headaches which happen for the first time
Danish: • migrænelignende hovedpineanfald eller anfald af stærk hovedpine, som du oplever for første gang
English: After a single dose of CE/BZA, bazedoxifene and baseline-adjusted total estrone were absorbed with a tmax of approximately 2 hours and 8.5 hours, respectively.
Danish: Efter én enkelt dosis konjugerede østrogener/bazedoxifen blev bazedoxifen og baselinekorrigeret total estron absorberet med et tmax på henholdsvis ca. 2 timer og 8,5 timer.
English: Oral oestrogen-only*
Danish: Oral østrogen alene*
English: The metabolism of oestrogens may be increased by concomitant use of substances known to induce drug-metabolising enzymes, such as anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine) and anti-infectives (e.g., rifampicin, rifabutin, nevirapine, efavirenz).
Danish: Metabolismen af østrogener kan forøges ved samtidig indtagelse af stoffer, som er kendt for at inducere lægemiddel-metaboliserende enzymer såsom antiepileptika (f. eks. phenobarbital, phenytoin og carbamazepin), og antimikrobielle lægemidler (f. eks. rifampicin, rifabutin, nevirapin og efavirenz).
English: This medicine is for use only by postmenopausal women.
Danish: Dette lægemiddel må kun anvendes til kvinder i overgangsalderen (menopausen).
English: Not known
Danish: Ikke almindelig Ikke kendt
English: EXP After opening the blister pouch, use within 60 days.
Danish: EXP Anvendes inden for 60 dage efter åbning af blisterposen.
English: Systemic exposure (AUC) to bazedoxifene in these groups was 35 and 69 times that in postmenopausal women administered 20 mg/day for 14 days.
Danish: Den systemiske eksponering (AUC) for bazedoxifen i disse grupper var 35 og 69 gange eksponeringen hos postmenopausale kvinder, der fik 20 mg/dag i 14 dage.
English: A reduction in bazedoxifene exposure may be associated with an increased risk of endometrial hyperplasia (see section 4.4).
Danish: En reduktion af bazedoxifen-eksponeringen kan være associeret med en øget risiko for endometrie-hyperplasi (se pkt.
English: • dimpling of the skin
Danish: • fordybninger i huden
English: • A severe allergic reaction - symptoms may include sudden wheezing and chest pain or tightness, swelling of the eyelids, face, lips, mouth, tongue or throat, difficulty breathing, collapse
Danish: • En alvorlig allergisk reaktion - symptomerne kan omfatte pludselig hiven efter vejret og smerter eller sammentrækning i brystet, hævelse af øjenlåg, ansigt, læber, mund, tunge eller hals, åndenød, kollaps
English: Detectable amounts of oestrogens have been identified in the milk of mothers receiving CE. Oestrogen administration to breast-feeding mothers has been shown to decrease the quantity and quality of the milk.
Danish: Det er påvist, at administration af østrogen til ammende mødre har nedsat mængden og kvaliteten af mælken.
English: Bazedoxifene Baseline-adjusted total estrone
Danish: Bazedoxifen Baselinekorrigeret total estron
English: For women aged 50 to 54 years taking 5 years of HRT, this results in about 1 extra case per 2,000 users.
Danish: For kvinder i alderen 50-54 år, der har taget HRT i 5 år, svarer det til ca. 1 yderligere tilfælde pr. 2.000 brugere.
English: In clinical trials of up to 2 years duration in postmenopausal women with CE/BZA, cases of VTE have been reported (see section 4.8).
Danish: I kliniske studier af op til 2 års varighed hos postmenopausale kvinder med konjugerede østrogener/bazedoxifen er der rapporteret om tilfælde af VTE (se pkt.
English: Bazedoxifene active coating
Danish: Bazedoxifen aktivt overtræk
English: This may be accompanied by bone pain and abdominal pain.
Danish: Dette kan være ledsaget af knoglesmerter og mavesmerter.
English: Hypersensitivity Angioedema; anaphylactic/ana phylactoid reactions; urticaria
Danish: Overfølsomhed Angioødem, anafylaktiske/ anafylaktoide reaktioner, urticaria
English: Oestrogens may be poorly metabolised in women with impaired liver function.
Danish: Metabolisering af østrogener kan være reduceret hos kvinder med nedsat leverfunktion.
English: Food had little or no effect on the exposure of CE.
Danish: Mad havde ringe eller ingen virkning på eksponeringen af konjugerede østrogener.
English: BZA is extensively metabolised in women.
Danish: Bazedoxifen metaboliseres i udtalt grad hos kvinder.
English: • smoking
Danish: • rygning
English: • Changes in your interest in sex (increased or decreased libido)
Danish: • Ændringer i sexlysten (øget eller nedsat libido)
English: When single doses of CE 0.625 mg/BZA 20 mg were administered with a high-fat meal, bazedoxifene Cmax was unaffected, but Area Under Curve (AUC) increased by approximately 25%.
Danish: Ved administration af enkeltdoser af konjugerede østrogener 0,625 mg/bazedoxifen 20 mg sammen med et fedtholdigt måltid var bazedoxifen Cmax upåvirket, mens arealet under kurven (AUC) steg med ca. 25 %.
English: Venous thromboembolism (VTE)
Danish: Venøs tromboemboli (VTE)
English: What you need to know before you take DUAVIVE
Danish: Det skal du vide, før du begynder at tage Duavive
English: Women taking CE/BZA should not be taking progestins, additional oestrogens or selective oestrogen receptor modulators (SERMs).
Danish: Kvinder, der tager konjugerede østrogener/bazedoxifen, bør ikke tage syntetiske gestagener, yderligere østrogener eller selektive østrogenreceptormodulatorer.
English: There is no evidence from randomised controlled trials of protection against myocardial infarction in women with or without existing CAD who received oestrogen-only therapy.
Danish: Randomiserede, kontrollerede studier har ikke kunnet påvise beskyttelse mod myokardieinfarkt hos kvinder med eller uden eksisterende koronar arteriesygdom, der fik behandling med østrogen alene.
English: Symptoms of overdose of oestrogen-containing medicinal products in adults and children may include nausea, vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue; withdrawal bleeding may occur in females.
Danish: Symptomer på overdosering med østrogenholdige lægemidler kan hos voksne og børn omfatte kvalme, opkastning, brystømhed, svimmelhed, abdominalsmerter og sløvhed/træthed.
English: In a 1 year study, CE 0.45 mg/BZA 20 mg showed a significant difference from baseline in lumbar spine BMD (+1.52%) at month 12 compared to placebo.
Danish: I et 1 års studie viste konjugerede østrogener 0,45 mg/bazedoxefin 20 mg en signifikant forskel fra baseline for BMD af columna lumbalis (+1,52 %) ved 12. måned sammenlignet med placebo.
English: Effects on bone mineral density (BMD)
Danish: Indvirkninger på knoglemineraltæthed (BMD)
English: Hypromellose 2910 (6 mPa•s) (E464) Titanium dioxide (E171) Macrogol (400)
Danish: Hypromellose 2910 (6 mPa•s) (E464) Titaniumdioxid (E171) Macrogol (400)
English: If you have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency).
Danish: - Hvis du har en blodstørkningsforstyrrelse (f. eks. protein C-, protein S- eller antitrombinmangel).
English: Hirsutism; rash; pruritus; chloasma
Danish: Hirsutisme, udslæt, pruritus; chloasma
English: Pink, oval-shaped, modified-release tablet of 12 mm printed on one side with “0.45/20”.
Danish: Lyserød, oval tablet på 12 mm med modificeret udløsning præget med "0,45/20" på den ene side.
English: In 6-month carcinogenicity studies in transgenic mice, there was an increased incidence of benign, ovarian granulosa-cell tumours in female mice given 150 or 500 mg/kg/day.
Danish: I 6-måneders karcinogenicitetsforsøg med transgene mus var der en øget incidens af benigne granulosacelletumorer i ovarierne hos hunmus, der fik 150 eller 500 mg/kg/dag.
English: The DUAVIVE 0.45 mg/20 mg modified-release tablet is a pink, oval-shaped, tablet marked on one side with “0.45/20”.
Danish: Duavive 0,45 mg/20 mg-tabletten med modificeret udløsning er en lyserød, oval tablet med "0,45/20" markeret på den ene side.
English: Oestrogens are known to increase the risk of VTE (see section 4.4).
Danish: Østrogener er kendt for at øge risikoen for VTE (se pkt.
English: WHI Studies combined - Additional risk of ischaemic stroke* over 5 years use Age range (years) Incidence per 1,000 women in placebo arm over 5 years
Danish: WHI-studier samlet set - yderligere risiko for iskæmisk apopleksi* ved mere end 5 års anvendelse Aldersgruppe (år) Incidens pr. 1.000 kvinder i placebo-arm over 5 år
English: As oestrogens promote the growth of the endometrium, unopposed oestrogens increase the risk of endometrial hyperplasia and cancer.
Danish: Da østrogener fremmer væksten af endometriet, kan østrogener alene øge risikoen for endometriehyperplasi og -cancer.
English: • Changes in breast tissue
Danish: • Forandringer i brystvævet
English: Other medicines and DUAVIVE
Danish: Brug af anden medicin sammen med Duavive
English: Black Iron oxide (E172) Propylene glycol (E1520) Hypromellose 2910 (6 mPa•s)
Danish: Sort jernoxid (E172) Propylenglycol (E1520) Hypromellose 2910 (6 mPa•s)
English: DUAVIVE contains lactose, sucrose, maltitol liquid, glucose and sorbitol
Danish: Duavive indeholder lactose, saccharose, flydende maltitol, glucose og sorbitol
English: Uncommon: may affect 1 in 100 people • Gall bladder disease (e.g. gallstones, inflammation of the gall bladder (cholecystitis))
Danish: Ikke almindelige: kan forekomme hos op til 1 ud af 100 personer • Galdeblæresygdom (f. eks. galdesten, betændelse i galdeblæren (cholecystitis))
English: In a 12-week study, CE 0.45 mg/BZA 20 mg significantly reduced the number and severity of hot flushes compared to placebo at weeks 4 and 12.
Danish: I et 12ugers studie reducerede konjugerede østrogener 0,45 mg/bazedoxifen 20 mg signifikant både antallet og sværhedsgraden af hedeture i forhold til placebo ved uge 4 og 12.
English: After a single dose of CE/BZA, baseline-adjusted total estrone (representing CE) is eliminated with a half-life of approximately 17 hours.
Danish: Efter én enkelt dosis konjugerede østrogener /bazedoxifen blev baselinekorrigeret total estron (repræsenterende konjugerede østrogener) elimineret med en halveringstid på ca. 17 timer.
English: Migraine; headache; dizziness; nervousness
Danish: Migræne, hovedpine, svimmelhed, nervøsitet
English: In a 2-year carcinogenicity study in rats, an increased incidence of benign, ovarian granulosa-cell tumours was observed in female rats at dietary concentrations of 0.03% and 0.1%.
Danish: I et 2-årigt karcinogenicitetsforsøg med rotter blev der observeret en øget incidens af benigne granulosacelletumorer i ovarierne hos hunrotter ved koncentrationer i kosten på 0,03 % og 0,1 %.
English: - kidney problems - pre-existing high level of fat in your blood (triglycerides) - liver problems - asthma - seizures (epilepsy) - migraine - systemic lupus erythematosus (SLE - a rare disease of the immune system that affects many organs of the body) - fluid retention
Danish: Hvis du har noget af følgende, bør din læge overvåge dig: - nyreproblemer - et allerede eksisterende højt fedtindhold i blodet (triglycerider) - leverproblemer - astma - epileptiske anfald - migræne - systemisk lupus erythematosus (SLE - en sjælden sygdom i immunsystemet, som påvirker mange af kroppens organer) - væskeophobning.
English: Venous thromboembolic events (including, pulmonary embolism, retinal vein thrombosis, deep vein thrombosis and thrombophlebitis)
Danish: Venøse tromboemboliske hændelser (herunder lungeemboli, retinal venetrombose, dyb venetrombose og tromboflebitis).
English: - Acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal.
Danish: - Akut eller tidligere leversygdom, så længe leverfunktions-værdierne ikke er normaliseret.
English: WHI studies oestrogen only arm - additional risk of VTE over 5 years' use Age range (years) Incidence per 1,000 women in placebo arm over 5 years
Danish: WHI-studier østrogen alene-arm - yderligere risiko for VTE ved mere end 5 års anvendelse Aldersgruppe (år) Incidens pr. 1.000 kvinder i placebo-arm over 5 år
English: Microcrystalline cellulose Hydroxypropylcellulose Hypromellose 2910 (6 mPa•s) (E464) Hypromellose 2910 (15 mPa•s) (E464) Macrogol (400)
Danish: Mikrokrystallinsk cellulose Hydroxypropylcellulose Hypromellose 2910 (6 mPa•s) (E464) Hypromellose 2910 (15 mPa•s) (E464) Macrogol (400)
English: Any increased risk to users of oestrogen-only therapy is substantially lower than that seen in users of oestrogen-progestagen combinations.
Danish: En eventuel øget risiko ved behandling med østrogen alene, er væsentligt lavere end ved behandling med østrogen-gestagen-kombinationer.
English: If you are allergic to conjugated estrogens, bazedoxifene or any of the other ingredients of this medicine (listed in section 6).
Danish: Tag ikke Duavive - Hvis du er allergisk over for konjugerede østrogener, bazedoxifen eller et af de øvrige indholdsstoffer i Duavive (angivet i punkt 6).
English: • Swelling of the eyes, nose, lips, mouth, tongue or throat, difficulty in breathing, severe dizziness or fainting, skin rash (symptoms of angioedema)
Danish: • Hævelse af øjne, næse, læber, mund, tunge eller hals, åndenød, alvorlig svimmelhed eller besvimelse, hududslæt (symptomer på angioødem)
English: Oestrogen dose proportionality was assessed in two studies of CE. Dose-proportional increases in both AUC and Cmax were observed across the dose range from 0.3 mg to 0.625 mg of CE for total (conjugated plus unconjugated) equilin, total estrone adjusted for baseline, and unconjugated estrone adjusted for baseline.
Danish: Dosis-proportionale stigninger i både AUC og Cmax blev observeret i hele dosisintervallet fra 0,3-0,625 mg konjugerede østrogener for total (konjugeret plus ukonjugeret) equilin, total estron korrigeret ved baseline og ukonjugeret estron korrigeret ved baseline.
English: • a large increase in your blood pressure (symptoms may be headache, tiredness, dizziness)
Danish: • En stor stigning i blodtrykket (symptomer kan være hovedpine, træthed, svimmelhed)
English: Conjugated oestrogens
Danish: Konjugerede østrogener
English: • A worsening of epilepsy (seizures)
Danish: • Forværring af epilepsi (krampeanfald)
English: Enlargement of hepatic haemangiomas
Danish: Forstørrelse af hepatiske hæmangiomer
English: There is no experience in treating women with a premature menopause (due to ovarian failure or surgery) with DUAVIVE.
Danish: Der er ingen erfaring med behandling med Duavive til kvinder, der har tidlig overgangsalder (på grund af svigtende æggestokke eller operation).
English: Hypromellose 2910 (3 mPa•s) (E464) Sucrose monopalmitate Ascorbic acid
Danish: Hypromellose 2910 (3 mPa•s) (E464) Sucrosemonopalmitat Ascorbinsyre
English: • Symptoms of pancreatitis which may include severe upper abdominal pain which may spread to your back, accompanied by abdominal swelling, fever, nausea and vomiting
Danish: • Symptomer på betændelse i bugspytkirtlen (pankreatitis), som kan omfatte alvorlige smerter i den øvre del af maven, der kan brede sig til ryggen, ledsaget af oppustetmave, feber, kvalme og opkastning
English: The Women's Health Initiative (WHI) trial found no increase in the risk of breast cancer in hysterectomised women using oestrogen-only therapy.
Danish: Women's Health Initiative studiet (WHI studiet) fandt ingen stigning i risikoen for brystcancer hos hysterektomerede kvinder, der var behandlet med østrogen alene.
English: (see sections 4.6 and 5.3).
Danish: 4.6 og 5.3).
English: If pregnancy occurs during treatment with CE/BZA, it should be withdrawn immediately.
Danish: Hvis der opstår graviditet under behandling med konjugerede østrogener/bazedoxifen, skal behandlingen straks seponeres.
English: Breast cancer risk
Danish: Risiko for brystcancer
English: • Thrush (vaginal yeast infection)
Danish: • Trøske (vaginal svampeinfektion)
English: The recommended dose is 0.45 mg conjugated oestrogens (CE) and 20 mg bazedoxifene (BZA) taken as a single oral tablet, once daily.
Danish: Den anbefalede dosis er 0,45 mg konjugerede østrogener og 20 mg bazedoxifen taget som en enkelt oral tablet, én gang dagligt.