FrancophonIA/ELRC3.0 huggingface dataset:
English: If you have forgotten to take your capsules in the morning, take them as soon as possible on the same day.
Croatian: Ako ste ujutro zaboravili uzeti kapsule, uzmite ih čim prije istog dana.
English: Other interactions leading to clinically detrimental effects
Croatian: Druge interakcije koje dovode do klinički štetnih učinaka
English: After opening the aluminium wrapper: 1 year
Croatian: Nakon otvaranja aluminijskog omota: 1 godina
English: The course of preexisting infections may be aggravated.
Croatian: Tijek postojećih infekcija može se pogoršati.
English: Limited data are available but no recommendation on a posology can be made.
Croatian: Dostupni su ograničeni podaci međutim nije moguće dati preporuku o doziranju.
English: Other medicines and Tacforius
Croatian: Drugi lijekovi i Tacforius
English: If you are pregnant or breast-feeding, think you might be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego uzmete ovaj lijek.
English: What Tacforius is and what it is used for
Croatian: Što je Tacforius i za što se koristi
English: Elderly There is no evidence currently available to indicate that dosing should be adjusted in the elderly.
Croatian: Starije osobe Trenutno nema dostupnih dokaza koji pokazuju da se u starijih osoba mora prilagoditi doza.
English: If you take more Tacforius than you should
Croatian: Ako uzmete više Tacforiusa nego što ste trebali
English: Tacforius is used in adults.
Croatian: Tacforius se primjenjuje u odraslih.
English: Contents of the pack and other information What Tacforius contains
Croatian: Sadržaj pakiranja i druge informacije Što Tacforius sadrži
English: If you have accidentally taken too many capsules, contact your doctor or nearest hospital emergency department immediately.
Croatian: Ako ste slučajno uzeli previše kapsula, odmah se javite liječniku ili otiđite u najbližu službu hitne pomoći.
English: Tacforius is not recommended for use in children below 18 years due to limited data on safety and/or efficacy.
Croatian: Ne preporučuje se primjena Tacforiusa u djece mlađe od 18 godina, zbog ograničenih podataka o sigurnosti i/ili djelotvornosti.
English: Following your organ transplant (liver, kidney), your body's immune system will try to reject the new organ.
Croatian: Nakon presađivanja organa (jetre, bubrega), Vaš imunološki sustav pokušat će odbaciti novi organ.
English: Therefore, you may be more prone to infections while you are taking Tacforius.
Croatian: Zbog toga možete postati osjetljiviji na infekcije dok uzimate Tacforius.
English: - if you are allergic to tacrolimus or any of the other ingredients of this medicine (listed in section 6).
Croatian: - ako ste alergični na takrolimus ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: 98.8%) to plasma proteins, mainly to serum albumin and α - 1-acid glycoprotein.
Croatian: (> 98,8%) za proteine plazme, uglavnom za serumski albumin i α-1-kiseli glikoprotein.
English: What Tacforius looks like and contents of the pack
Croatian: Kako Tacforius izgleda i sadržaj pakiranja
English: Tubing, syringes and other equipment used to prepare a suspension of Tacforius capsule contents must not contain PVC.
Croatian: Cijevi, štrcaljke i ostali pribor koji se koristi u pripremi suspenzije sadržaja kapsule Tacforiusa ne smije sadržavati PVC.
English: Your doctor will usually reduce your Tacforius dose once your condition has stabilised.
Croatian: Liječnik će obično smanjiti dozu Tacforiusa kad Vam se stanje stabilizira.
English: The safety and efficacy of Tacforius in children under 18 years of age have not yet been established.
Croatian: Sigurnost i djelotvornost Tacforiusa u djece mlađe od 18 godina nisu još ustanovljene.
English: You will need to take Tacforius every day as long as you need immunosuppression to prevent rejection of your transplanted organ.
Croatian: Tacforius ćete morati uzimati svakodnevno, sve dok Vam je potrebna imunosupresija, da bi se spriječilo odbacivanje presađenog organa.
English: As detrimental effects on the newborn cannot be excluded, women should not breast-feed whilst receiving Tacforius.
Croatian: Budući da se ne mogu isključiti štetni učinci na novorođenče, žene ne bi smjele dojiti dok uzimaju Tacforius.
English: Administration should commence approximately 12 - 18 hours after the completion of surgery.
Croatian: S primjenom treba započeti oko 12-18 sati nakon završetka operacije.
English: fever, nausea or vomiting - if you have an alteration of the electrical activity of your heart called “QT prolongation”.
Croatian: mučnina ili povraćanje - ako imate promjenu električne aktivnosti srca zvane „produljenje QT-a“.
English: It is not recommended that Tacforius is taken with ciclosporin (another medicine used for the prevention of transplant organ rejection).
Croatian: Ne preporučuje se uzimanje Tacforiusa zajedno s ciklosporinom (drugi lijek koji se koristi za sprječavanje odbacivanja organa nakon presađivanja).
English: Positive EBV-PCR may persist for months and is per se not indicative of lymphoproliferative disease or lymphoma.
Croatian: Pozitivan nalaz PCR-a na EBV može trajati mjesecima i nije sam po sebi indikativan za limfoproliferativnu bolest ili limfom.
English: Not known (frequency cannot be estimated from the available data) - Abnormality of the optic nerve (optic neuropathy)
Croatian: Nepoznato (učestalost se ne može procijeniti iz dostupnih podataka): - poremećaj vidnog živca (optička neuropatija)
English: As gastrointestinal perforation is a medically important event that may lead to a life-threatening or serious condition, adequate treatments should be considered immediately after suspected symptoms or signs occur.
Croatian: S obzirom na to da je gastrointestinalna perforacija medicinski važan događaj koji može dovesti do ozbiljnog stanja ili stanja opasnog po život, trebalo bi provesti adekvatno liječenje odmah nakon sumnje na simptome ili znakove koji se pojave.
English: Your doctor may need to adjust your dose of Tacforius.
Croatian: Liječnik će Vam možda morati prilagoditi dozu Tacforiusa.
English: C/C, n. 4, Poligono Industrial Malpica ES-50016 Zaragoza Spain
Croatian: 4, Poligono Industrial Malpica ES-50016 Zaragoza Španjolska
English: Tacforius reduces your body's defence mechanism (immune system), which will not be as good at fighting infections.
Croatian: Tacforius slabi obrambene mehanizme tijela (imunološki sustav), koji neće biti tako učinkovit u obrani od infekcija kao obično.
English: Tacforius should be administered in the morning.
Croatian: Tacforius je potrebno uzimati ujutro.
English: Certain combinations of tacrolimus with substances known to have nephrotoxic or neurotoxic effects may increase the risk of these effects (see section 4.5).
Croatian: Određene kombinacije takrolimusa i lijekova koje imaju nefrotoksične ili neurotoksične učinke mogu povisiti rizik od takvih učinaka (vidjeti dio 4.5).
English: Ostravská 29, č.p.
Croatian: Ostravská 29, c.p. 305
English: The use of Tacforius is not recommended in children and adolescents under 18 years.
Croatian: Ne preporučuje se primjena Tacforiusa u djece i adolescenata mlađih od 18 godina.
English: Tacforius therapy requires careful monitoring by adequately qualified and equipped personnel.
Croatian: Liječenje Tacforiusom mora biti pod strogim nadzorom odgovarajuće obučenih i opremljenih zdravstvenih radnika.
English: If signs of toxicity such as severe adverse reactions are noted (see section 4.8), the dose of Tacforius may need to be reduced.
Croatian: U slučaju da se primijete znakovi toksičnosti, kao što su teške nuspojave (vidjeti dio 4.8), možda će biti potrebno smanjiti dozu Tacforiusa.
English: From time to time, your doctor may need to do blood, urine, heart, eye tests, to set the right dose of Tacforius.
Croatian: Liječnik će Vam s vremena na vrijeme napraviti pretrage krvi, mokraće, srca i očiju, kako bi odredio pravu dozu Tacforiusa.
English: Significantly more ciclosporin-treated patients (n = 13) required a switch to tacrolimus than tacrolimus-treated patients to ciclosporin (n = 2) (p = 0.02) (Keenan et al., Ann Thoracic Surg 1995;60:580).
Croatian: Značajno više bolesnika liječenih ciklosporinom (n = 13) moralo je zamijeniti terapiju i prebaciti se na takrolimus, nego što se bolesnika liječenih takrolimusom moralo prebaciti na ciklosporin (n = 2) (p = 0,02) (Keenan et al., Ann Thoracic Surg 1995;60:580).
English: In cases of oral intoxication, gastric lavage and/or the use of adsorbents (such as activated charcoal) may be helpful, if used shortly after intake.
Croatian: U slučaju intoksikacije oralnim putem, ispiranje želuca i/ili primjena adsorbensa (poput aktivnog ugljena) mogu biti od pomoći ako se primijene ubrzo nakon uzimanja takrolimusa.
English: No studies on the effects of tacrolimus on the ability to drive and use machines have been performed.
Croatian: Nisu provedena ispitivanja učinaka takrolimusa na sposobnost upravljanja vozilima i rada sa strojevima.
English: Tell your doctor immediately if during treatment you suffer from: - problems with your vision such as blurred vision, changes in colour vision, difficulty in seeing detail or if your field of vision becomes restricted.
Croatian: Odmah obavijestite liječnika ako tijekom liječenja primijetite: - probleme s vidom kao što su zamagljen vid, promjene vida u boji, otežano uočavanje detalja, ili ako Vam vidno polje postane ograničeno.
English: Tacforius is a prolonged-release formulation of tacrolimus resulting in an extended oral absorption profile with an average time to maximum blood concentration (Cmax) of approximately 2 hours (tmax).
Croatian: Tacforius je formulacija takrolimusa s produljenim oslobađanjem što rezultira produljenim apsorpcijskim profilom nakon peroralne primjene uz srednje vrijeme do postizanja maksimalne koncentracije u krvi (Cmax) od otprilike 2 sata (tmax).
English: 0.5 mg, 1 mg, 3 mg Contains lactose.
Croatian: 0,5 mg, 1 mg, 3 mg Sadrži laktozu.
English: fat tissue increased
Croatian: povećanje masnog tkiva
English: Tacforius is used to control your body's immune response, enabling your body to accept the transplanted organ.
Croatian: Tacforius se primjenjuje za obuzdavanje imunološkog odgovora tijela, čime mu se omogućuje da prihvati presađeni organ.
English: The frequency of adverse reactions is defined as follows: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000), not known (cannot be estimated from the available data).
Croatian: manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000), nepoznato
English: Stopping your treatment with Tacforius may increase the risk of rejection of your transplanted organ.
Croatian: Prestanak liječenja Tacforiusom može povisiti rizik od odbacivanja presađenog organa.
English: However, Tacforius prolonged-release capsules are taken once daily, whereas the immediate release capsules are taken twice daily.
Croatian: Međutim, Tacforius kapsule s produljenim oslobađanjem uzimaju se jedanput na dan, dok se kapsule s trenutnim oslobađanjem uzimaju dvaput na dan.
English: Tacforius is routinely administered in conjunction with other immunosuppressive agents in the initial postoperative period.
Croatian: Tacforius se rutinski primjenjuje zajedno s drugim imunosupresivnim lijekovima u ranom poslijeoperacijskom razdoblju.
English: In rats, female reproductive function including birth was impaired at toxic doses and the offspring showed reduced birth weights, viability and growth.
Croatian: U ženki štakora je pri toksičnim dozama bila narušena reproduktivna funkcija, uključujući okot, dok je mladunčad pokazala smanjenu porođajnu težinu, preživljavanje i rast.
English: What you need to know before you take Tacforius 3.
Croatian: Što morate znati prije nego počnete uzimati Tacforius
English: You may also be given Tacforius for an ongoing rejection of your transplanted liver, kidney, heart or other organ when any previous treatment you were taking was unable to control this immune response after your transplantation.
Croatian: Tacforius možete primiti i kad već imate reakciju odbacivanja presatka jetre, bubrega, srca ili nekog drugog organa, kada se terapijom koju ste prethodno uzimali nije mogao obuzdati imunološki odgovor nakon presađivanja.
English: - if you are allergic to sirolimus or to any macrolide-antibiotic (e.g. erythromycin, clarithromycin, josamycin).
Croatian: - ako ste alergični na sirolimus ili neki makrolidni antibiotik (npr. eritromicin, klaritromicin,
English: Tacforius therapy should be initiated after considering ciclosporin blood concentrations and the clinical condition of the patient.
Croatian: Liječenje Tacforiusom treba započeti nakon razmatranja koncentracije ciklosporina u krvi i kliničkog stanja bolesnika.
English: Following the initiation of your treatment with Tacforius, frequent blood tests will be taken by your doctor to define the correct dose.
Croatian: U početku liječenja Tacforiusom, liječnik će Vam često raditi krvne pretrage kako bi odredio ispravnu dozu.
English: Active substances which interfere with mycophenolic acid's enterohepatic cycle have potential to reduce the plasma level and efficacy of mycophenolic acid.
Croatian: Djelatne tvari koje utječu na enterohepatični ciklus mikofenolatne kiseline mogu smanjiti plazmatsku razinu i djelotvornost mikofenolatne kiseline.
English: Prilaz baruna Filipovica 25 10 000 Zagreb Croatia
Croatian: PLIVA Hrvatska d.o.o. Prilaz baruna Filipovica 25 10 000 Zagreb Hrvatska
English: EU/1/17/1244/001 30 capsules EU/1/17/1244/002 30x1 capsules EU/1/17/1244/003 50 capsules EU/1/17/1244/004 50x1 capsules EU/1/17/1244/005 100 capsules EU/1/17/1244/006 100x1 capsules EU/1/17/1244/007 30 capsules EU/1/17/1244/008 30x1 capsules EU/1/17/1244/009 50 capsules EU/1/17/1244/010 50x1 capsules EU/1/17/1244/011 60 capsules EU/1/17/1244/012 60x1 capsules EU/1/17/1244/013 100 capsules EU/1/17/1244/014 100x1 capsules EU/1/17/1244/015 30 capsules EU/1/17/1244/016 30x1 capsules EU/1/17/1244/017 50 capsules EU/1/17/1244/018 50x1 capsules EU/1/17/1244/019 100 capsules EU/1/17/1244/020 100x1 capsules EU/1/17/1244/021 30 capsules EU/1/17/1244/022 30x1 capsules EU/1/17/1244/023 50 capsules EU/1/17/1244/024 50x1 capsules
Croatian: EU/1/17/1244/001 30 kapsula EU/1/17/1244/002 30x1 kapsula EU/1/17/1244/003 50 kapsula EU/1/17/1244/004 50x1 kapsula EU/1/17/1244/005 100 kapsula EU/1/17/1244/006 100x1 kapsula EU/1/17/1244/007 30 kapsula EU/1/17/1244/008 30x1 kapsula EU/1/17/1244/009 50 kapsula EU/1/17/1244/010 50x1 kapsula EU/1/17/1244/011 60 kapsula EU/1/17/1244/012 60x1 kapsula EU/1/17/1244/013 100 kapsula EU/1/17/1244/014 100x1 kapsula EU/1/17/1244/015 30 kapsula EU/1/17/1244/016 30x1 kapsula EU/1/17/1244/017 50 kapsula EU/1/17/1244/018 50x1 kapsula
English: Accordingly, highrisk patients receiving substantial immunosuppression should be monitored, using such procedures as echocardiography or ECG pre- and post-transplant (e.g. initially at 3 months and then at 9 - 12 months).
Croatian: Sukladno tome, visokorizični bolesnici pod jakom imunosupresijom moraju se pratiti pomoću ehokardiografskih i elektrokardiografskih metoda prije i poslije presađivanja organa (npr. prvo nakon 3 mjeseca, a potom nakon 9-12 mjeseci).
English: Avoid grapefruit (also as juice) while on treatment with Tacforius, since it can affect its levels in the blood.
Croatian: Izbjegavajte grejpfrut (i sok od grejpfruta) dok uzimate Tacforius, jer može utjecati na razinu lijeka u krvi.
English: The FKBP12-tacrolimus complex specifically and competitively binds to and inhibits calcineurin, leading to a calcium-dependent inhibition of T-cell signal transduction pathways, thereby preventing transcription of a discrete set of cytokine genes.
Croatian: Kompleks FKBP12 i takrolimusa specifično se i kompetitivno veže za kalcineurin i inhibira ga, što dovodi do inhibicije signalnih puteva T-stanica ovisne o kalciju i sprječava prepisivanje diskretne skupine gena za citokine.
English: This is because Tacforius capsules allow for a prolonged-release (more slow release over a longer period) of tacrolimus.
Croatian: Razlog tome je taj što kapsule Tacforiusa omogućuju produljeno oslobađanje takrolimusa (sporije oslobađanje tijekom duljeg razdoblja).
English: Tacforius doses are usually reduced in the post-transplant period.
Croatian: Doze Tacforiusa u razdoblju nakon presađivanja obično se snižavaju.
English: Overall, the safety profile of oral tacrolimus immediate release capsules in these published studies appeared to be similar to what was reported in the large studies, where tacrolimus immediate release capsules was used as primary treatment in liver, kidney and heart transplantation.
Croatian: Čini se da je općenito profil sigurnosti peroralno primijenjenog takrolimusa u kapsulama s trenutnim oslobađanjem u tim objavljenim ispitivanjima bio sličan onome navedenom u velikim ispitivanjima, u kojima se takrolimus u kapsulama s trenutnim oslobađanjem koristio kao primarna terapija nakon presađivanja jetre, bubrega i srca.
English: If you stop taking Tacforius
Croatian: Ako prestanete uzimati Tacforius
English: Patients treated with tacrolimus have been reported to develop posterior reversible encephalopathy syndrome (PRES).
Croatian: U bolesnika liječenih takrolimusom zabilježen je razvoj sindroma posteriorne reverzibilne encefalopatije (PRES).
English: Animal data have shown that tacrolimus could potentially decrease the clearance and increase the halflife of pentobarbital and antipyrine.
Croatian: Podaci iz ispitivanja na životinjama pokazuju da takrolimus može smanjiti klirens i produljiti poluvijek fenobarbitala i antipirina.
English: It is recommended that the oral daily dose of Tacforius be administered once daily in the morning.
Croatian: Preporučuje se primjena dnevne oralne doze Tacforiusa jedanput na dan, ujutro.
English: A lower incidence of acute rejection episodes for tacrolimus- versus ciclosporin-treated patients (11.5% versus 22.6%) and a lower incidence of chronic rejection, the bronchiolitis obliterans syndrome (2.86% versus 8.57%), was reported within the first year after transplantation.
Croatian: Zabilježena je niža incidencija akutnih epizoda odbacivanja u bolesnika liječenih takrolimusom nasuprot onih liječenih ciklosporinom (11,5% nasuprot 22,6%) i niža incidencija kroničnog odbacivanja, sindroma bronhiolitis obliteransa (2,86% nasuprot 8,57%) tijekom prve godine nakon presađivanja.
English: Each capsule contains 537.25 mg lactose and 0.0154 mg ponceau 4R.
Croatian: Jedna kapsula sadrži 537,25 mg laktoze i 0,0154 mg bojila ponceau 4R.
English: Take Tacforius on an empty stomach or 2 to 3 hours after a meal.
Croatian: Uzmite Tacforius na prazan želudac ili 2
English: The 1 - year patient survival was 83% in the tacrolimus and 71% in the ciclosporin group, the 2 - year survival rates were 76% and 66%, respectively.
Croatian: Jednogodišnje preživljenje bolesnika iznosilo je 83% u skupini na takrolimusu i 71% u skupini na ciklosporinu, dok su dvogodišnje stope preživljenja iznosile 76% za takrolimus i 66% za ciklosporin.
English: If patients taking tacrolimus present with symptoms indicating PRES such as headache, altered mental status, seizures, and visual disturbances, a radiological procedure (e.g. MRI) should be performed.
Croatian: Ako se u bolesnika koji uzimaju takrolimus pojave simptomi koji ukazuju na PRES, kao što su glavobolja, promjena mentalnog stanja, konvulzije i poremećaji vida, potrebno je napraviti radiološki pregled (npr. MR).
English: Ventricular hypertrophy or hypertrophy of the septum, reported as cardiomyopathies, have been observed in patients treated with immediate release tacrolimus on rare occasions and may also occur with prolonged-release tacrolimus.
Croatian: Ventrikularna hipertrofija i hipertrofija septuma, prijavljene kao kardiomiopatije, bile su primijećene u rijetkim prilikama u bolesnika liječenih takrolimusom s trenutnim oslobađanjem, a mogu nastati i s takrolimusom s produljenim oslobađanjem.
English: Peak blood concentrations achieved with these doses were above 150 ng/ml which is more than 6 - fold higher than mean peak concentrations observed with tacrolimus prolonged-release capsules in clinical transplantation.
Croatian: Vršna koncentracija u krvi postignuta s ovim dozama je bila viša od 150 ng/ml što je više nego 6 puta veće od srednjih vršnih koncentracija koje su uočene s takrolimusom u kapsulama s produljenim oslobađanjem u kliničkoj transplantaciji.
English: In case of in utero exposure, monitoring of the newborn for the potential adverse reactions of tacrolimus is recommended (in particular effects on the kidneys).
Croatian: U slučaju izloženosti in utero, preporučuje se praćenje novorođenčeta zbog mogućih nuspojava takrolimusa (osobito utjecaja na bubrege).
English: Absorption In man tacrolimus has been shown to be able to be absorbed throughout the gastrointestinal tract.
Croatian: Apsorpcija Pokazalo se da se takrolimus u ljudi apsorbira kroz cijeli gastrointestinalni trakt.
English: Tacrolimus is a known CYP3A4 inhibitor; thus concomitant use of tacrolimus with medicinal products known to be metabolised by CYP3A4 may affect the metabolism of such medicinal products.
Croatian: Takrolimus je poznati inhibitor CYP3A4 pa istodobna primjena takrolimusa s lijekovima koji se metaboliziraju putem CYP3A4 može utjecati na metabolizam takvih lijekova.
English: Tacforius contains lactose (milk sugar).
Croatian: Tacforius sadrži laktozu (mliječni šećer).
English: Freedom from acute rejection was higher in the tacrolimus group at 6 months (57.7% versus 45.8%) and at 1 year after lung transplantation (50% versus 33.3%).
Croatian: Izostanak akutnog odbacivanja bio je viši u skupini na takrolimusu nakon 6 mjeseci (57,7% nasuprot 45,8%) i jedne godine nakon presađivanja pluća (50%
English: Published clinical experience from a single centre on the use of oral tacrolimus immediate release capsules for primary treatment following intestinal transplantation showed that the actuarial survival rate of 155 patients (65 intestine alone, 75 liver and intestine, and 25 multivisceral) receiving tacrolimus and prednisone was 75% at 1 year, 54% at 5 years, and 42% at 10 years.
Croatian: Objavljena klinička iskustva iz jednog centra s primjenom oralnog takrolimusa u kapsulama s trenutnim oslobađanjem kao primarne terapije nakon presađivanja crijeva pokazala su da je aktuarska stopa preživljenja u 155 bolesnika (65 samo s presatkom crijeva, 75 s presatkom jetre i crijeva te 25 s presatcima više visceralnih organa) koji su primali takrolimus i prednizon bila 75% nakon jedne godine, 54% nakon 5 godina i 42% nakon 10 godina.
English: Clinical efficacy and safety of tacrolimus immediate release capsules bid in primary organ transplantation
Croatian: Klinička djelotvornost i sigurnost primjene takrolimusa u kapsulama s trenutnim oslobađanjem bid u primarnom presađivanju organa
English: All patients reported risk factors for PRCA such as parvovirus B19 infection, underlying disease or concomitant medications associated with PRCA.
Croatian: U svih su bolesnika zabilježeni čimbenici rizika za razvoj PRCA-e kao što je infekcija parvovirusom B19, osnovna bolest ili istodobno uzimanje lijekova koji su povezani s nastankom PRCA-e.
English: Tacforius blood levels can be affected by other medicines you take, and blood levels of other medicines can be affected by taking Tacforius, which may require interruption, an increase or a decrease in Tacforius dose.
Croatian: Razina Tacforiusa u krvi može se promijeniti zbog utjecaja drugih lijekova koje uzimate, kao što se i razine drugih lijekova u krvi mogu promijeniti zbog utjecaja Tacforiusa pa će možda biti potrebno prekinuti, povisiti ili sniziti dozu Tacforiusa.
English: It is possible in some cases to withdraw concomitant immunosuppressive therapy, leading to Tacforius monotherapy.
Croatian: U nekim se slučajevima može obustaviti istodobna imunosupresivna terapija i ostaviti monoterapija Tacforiusom.