FrancophonIA/ELRC3.0 huggingface dataset:
English: Live E. coli: 5.2 x 106 - 9.1 x 108 CFU/dose
Danish: Levende E. coli: 5,2 x 106 - 9,1 x 108 CFU/dosis
English: STATEMENT OF ACTIVE SUBSTANCES Active substance:
Danish: ANGIVELSE AF AKTIVE STOFFER
English: Pour the reconstituted vaccine into a clean container and add chlorine-free water to further dilute the vaccine in order to obtain an even distribution when sprayed onto the birds.
Danish: Hæld den rekonstituerede vaccine i en ren beholder og tilsæt chlorfrit vand for yderligere fortynding af vaccinen, for at opnå en jævn fordeling, når vaccinen sprayes på fuglene.
English: As a general rule, apply reconstituted vaccine to chlorine-free and fresh water at the rate of 1,000 doses of the vaccine to 1 litre of water per day of age for 1,000 chickens, e.g. 10 litres would be needed for 1,000 10-day old chickens.
Danish: Som hovedregel tilsættes rekonstitueret vaccine til frisk vand uden chlor i forholdet 1.000 doser vaccine til 1 liter vand i forhold til fuglenes alder i dage, dvs. til 1.000 kyllinger, der er 10 dage gamle, skal der eksempelvis bruges 10 liter vand.
English: Chickens and turkeys
Danish: DYREARTER Kyllinger og kalkuner
English: Turkeys: 3 weeks after second vaccination for the reduction of lesions and mortality.
Danish: Kalkuner: 3 uger efter administration af anden vaccination til reduktion af læsioner og mortalitet.
English: Do not vaccinate animals undergoing antibacterial or immunosuppressive treatment.
Danish: Dyr i antibakteriel eller immunosuppressiv behandling må ikke vaccineres.
English: No disinfectants or other substances impairing the performance of the live vaccine should be used in the sprayer.
Danish: Der må ikke anvendes desinfektionsmidler eller andre stoffer i forstøvningsudstyret, der kan nedsætte virkningen af den levende vaccine.
English: BATCH NUMBER
Danish: BATCHNUMMER Lot {nummer}
English: Half-fill the vial with chlorine-free water at room temperature.
Danish: Fyld hætteglasset halvt op med chlorfrit vand ved stuetemperatur.
English: Chickens (broilers, future layers/breeders) and turkeys.
Danish: Kyllinger (slagtekyllinger, kommende æglæggere/avlsdyr) og kalkuner.
English: The vaccine strain can be detected in tissues (liver, heart) until 6 days (chickens) or in tissues (thoracic air sacs) 4 days (turkeys) post vaccination.
Danish: Virusstammen kan påvises i væv (lever, hjerte) 6 dage (kylling) eller i væv (luftsække) 4 dage (kalkun) efter vaccination.
English: Care should be taken to empty the vial and its top completely by rinsing them in water.
Danish: Sørg for at tømme hætteglasset og hætten helt ved at skylle dem med vand.
English: 1 x 2,500 doses, 10 x 2,500 doses 1 x 5,000 doses, 10 x 5,000 doses 1 x 10,000 doses, 10 x 10,000 doses 1 x 20,000 doses, 10 x 20,000 doses
Danish: 1 x 2.500 doser, 10 x 2.500 doser 1 x 5.000 doser, 10 x 5.000 doser 1 x 10.000 doser, 10 x 10.000 doser 1 x 20.000 doser, 10 x 20.000 doser
English: 1/10 x 2,500, 5,000, 10,000, 20,000 doses
Danish: 1/10 x 2.500, 5.000, 10.000, 20.000 doser
English: 5.2 x 106 - 9.1 x 108 CFU/ds
Danish: 5,2 x 106 - 9,1 x 108 CFU*
English: Type I borosilicate glass vial of 10 ml for 2,500 and 5,000 dose-presentations and 50 ml for 10,000 and 20,000 dose-presentations with a bromobutyl rubber stopper sealed with aluminium crimp caps.
Danish: Type I borosilicat hætteglas med 10 ml til 2.500 og 5.000 dosis-pakninger og 50 ml til 10.000 og 20.000 dosis-pakninger med brombutylgummiprop, forseglet med krympehætte af aluminium.
English: Chickens: 2 weeks after vaccination for the reduction of lesions.
Danish: Kyllinger: 2 uger efter administration til reduktion af læsioner.
English: Chickens: One dose of vaccine from 1 day of age by coarse spray administration or one dose of vaccine from 5 days of age by drinking water administration.
Danish: Kyllinger: Én dosis af vaccinen fra dag 1 ved administration af grov spray eller én dosis af vaccinen fra dag 5 ved administration via drikkevand.
English: Avoid exposure of the vaccine suspension to sunlight.
Danish: Vaccinesuspensionen skal beskyttes mod sollys.
English: EU/2/12/140/001-008
Danish: MARKEDSFØRINGSTILLADELSENS NUMMER (NUMRE) EU/2/12/140/001-008
English: Turkeys: One dose of vaccine from 1 day of age followed by second dose of vaccine 3 weeks later by coarse spray administration.
Danish: Kalkuner: Én dosis af vaccinen fra dag 1 efterfulgt af anden dosis efter 3 uger ved administration af grov spray.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the vial.
Danish: Brug ikke dette veterinærlægemiddel efter den udløbsdato, der står på hætteglas efter EXP. Opbevaringstid efter rekonstituering ifølge anvisning: 2 timer.
English: 2,500 doses 5,000 doses 10,000 doses 20,000 doses
Danish: 2.500 doser 5.000 doser 10.000 doser 20.000 doser
English: QUALITATIVE AND QUANTITATIVE COMPOSITION
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING Én dosis indeholder:
English: THE WORDS “FOR ANIMAL TREATMENT ONLY”
Danish: TEKSTEN ”TIL DYR” Til dyr.
English: Chickens (broilers, future layers/breeders) and turkeys
Danish: DYREARTER Kyllinger: (slagtekyllinger, kommende æglæggere/avlsdyr) og kalkuner.
English: Immunosuppressed people should not be present during administration of the vaccine.
Danish: Personer med et svækket immunforsvar må ikke håndtere denne vaccine.
English: Coarse spray administration for chickens and turkeys or in drinking water use for chickens.
Danish: Administration via grov spray til kyllinger og kalkuner eller ved brug i drikkevand til kyllinger.
English: Poulvac E. coli lyophilisate for suspension for spray vaccination or for use in drinking water
Danish: Poulvac E. coli lyofilisat til suspension til sprayvaccination eller til brug i drikkevand
English: STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENT(S)
Danish: ANGIVELSE AF DE(T) AKTIVE STOF(FER) OG ANDRE INDHOLDSSTOFFER Én dosis indeholder:
English: Lyophilisate for suspension for spray vaccination or for use in drinking water
Danish: Lyofilisat til suspension til sprayvaccination eller til brug i drikkevand
English: Lyophilisate for suspension for spray vaccination or for use in drinking water.
Danish: Lyofilisat til suspension til sprayvaccination eller til brug i drikkevand.
English: Allow water to be consumed so that levels of drinkers are minimal before vaccine is applied.
Danish: Sørg for, at der er så lidt vand som muligt i vandautomaterne, før der tilsættes vaccine.
English: THE WORDS “KEEP OUT OF THE SIGHT AND REACH OF CHILDREN”
Danish: TEKSTEN “OPBEVARES UTILGÆNGELIGT FOR BØRN” Opbevares utilgængeligt for børn.
English: Poulvac E. coli lyophilisate for suspension for spray vaccination for chickens and turkeys or for use in drinking water for chickens
Danish: Poulvac E. coli lyofilisat til suspension til sprayvaccination til kyllinger og kalkuner eller til brug i drikkevand til kyllinger
English: PACKAGE LEAFLET Poulvac E. coli lyophilisate for suspension for spray vaccination for chickens and turkeys or for use in drinking water for chickens
Danish: INDLÆGSSEDDEL: Poulvac E. coli lyofilisat til suspension sprayvaccination til kyllinger og kalkuner eller til brug i drikkevand til kyllinger
English: Live aroA gene deleted Escherichia coli, type O78,
Danish: Levende Escherichia coli hvor aroA-genet er fjernet,
English: 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Danish: 4.10 Overdosering (symptomer, nødforanstaltninger, modgift), om nødvendigt Der er ikke observeret nogen bivirkninger efter administration af en 10-foldig overdosis af vaccinen.
English: Spray vaccination or for use in drinking water.
Danish: INDGIVELSESVEJ(E) Sprayvaccination eller til brug i drikkevand.
English: If you notice any serious effects or other effects not mentioned in this package leaflet, please inform your veterinary surgeon.
Danish: Dette gælder også bivirkninger, der ikke allerede er anført i denne indlægsseddel eller hvis du mener, at dette lægemiddel ikke har virket efter anbefalingerne.
English: TARGET SPECIES
Danish: Æglæggende fugle:
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Cardboard box of one vial of 2,500 or 5,000 or 10,000 or 20,000 doses Cardboard box of ten vials of 2,500 or 5,000 or 10,000 or 20,000 doses
Danish: Æske med ét hætteglas som indeholder 2.500, 5.000, 10.000 eller 20.000 doser Æske med 10 hætteglas som indeholder 2.500, 5.000, 10.000 eller 20.000 doser
English: ADVERSE REACTIONS
Danish: BIVIRKNINGER
English: Live aroA gene deleted Escherichia coli, type O78, strain EC34195
Danish: Levende Escherichia coli hvor aroA-genet er fjernet, type O78, 5,2 x 106 - 9,1 x 108 CFU/dosis
English: Cardboard box of ten vials of 2,500, 5,000, 10,000 or 20,000 doses.
Danish: Æske med én hætteglas med 2.500, 5.000, 10.000 eller 20.000 doser Æske med 10 hætteglas med 2.500, 5.000, 10.000 eller 20.000 doser
English: 5.2 x 106 - 9.1 x 108 CFU* * Colony forming units when grown on tryptic soy agar plates.
Danish: type O78, stamme EC34195 *Kolonidannende enheder, efter vækst på trypticase-soja-agarplader Alle hjælpestoffer er anført under pkt.
English: EU/1/16/1104/001
Danish: EU/1/16/1104/001 Palonosetron Accord mikrogram
English: Intravenous use vial (glass) 5 ml
Danish: Hætteglas (glas) 5 ml
English: MA (EU) number
Danish: MF (EU)-nummer (Særnavn) navn
English: Content (concentration)
Danish: Styrke Lægemiddelform Administration Emballage Indhold (koncentration)
English: EU/1/19/1367/001 Zynteglo cells/mL
Danish: EU/1/19/1367/001 Zynteglo celler/ml
English: 1 bag (or more)
Danish: 1 pose (eller mere)
English: 20 ml
Danish: Pose (FEP) 20 ml
English: Dispersion for infusion
Danish: Infusionsvæske, dispersion
English: The following indication should be deleted:
Danish: Følgende indikation skal slettes:
English: One capsule daily.
Danish: En kapsel dagligt.
English: The usual dose is one capsule a day.
Danish: Den sædvanlige dosis er en kapsel dagligt.
English: The product information may be subsequently updated by the Member State competent authorities, in liaison with the Reference Member State, as appropriate, in accordance with the procedures laid down in Chapter 4 of Title III of Directive 2001/83/EC.
Danish: Produktinformationen kan efterfølgende opdateres af medlemsstaternes kompetente myndigheder, eventuelt i samarbejde med referencemedlemsstaten, i henhold til procedurerne i afsnit III, kapitel 4, i direktiv 2001/83/EF.
English: Post Myocardial Infarction
Danish: Efter myokardieinfarkt
English: Annex III Amendments to relevant sections of the Product Information
Danish: Bilag III Ændringer til relevante punkter af produktinformationen
English: B. Package Leaflet: Information for the patient
Danish: B. Indlægsseddel: Information til patienten
English: Section 1
Danish: Punkt 1
English: Section 3
Danish: Punkt 3
English: Section 4.1: Therapeutic indications
Danish: Punkt 4.1: Terapeutiske indikationer
English: These amendments to the relevant sections of the Product Information are the outcome of the referral procedure.
Danish: Disse ændringer af de relevante punkter i produktinformationen er en følge af henvisningsproceduren.
English: Existing relevant information on use after a heart attack should be deleted.
Danish: De eksisterende relevante oplysninger om brug efter et hjerteanfald skal slettes.
English: Adjuvant treatment in secondary prevention after myocardial infarction, in addition to other standard therapy (e.g. statins, anti-platelet medicinal products, beta-blockers, ACE inhibitors).
Danish: Adjuverende behandling ved sekundær forebyggelse efter myokardieinfarkt i tillæg til andre standardbehandlinger (f.eks. statiner, trombocythæmmende lægemidler, betablokkere og ACEhæmmere).
English: The heading and information on dose after a heart attack should be deleted: Dose after a heart attack
Danish: Overskriften og oplysningerne om dosering efter et hjerteanfald skal slettes: Dosis efter hjerteanfald
English: Existing relevant text in section 5.1 of the SmPC in relation to “secondary prevention after myocardial infarction” indication should be deleted.
Danish: Den eksisterende relevante tekst under punkt 5.1 i produktresuméet vedrørende "sekundær forebyggelse efter myokardieinfarkt" skal slettes.
English: For omega-3 containing medicinal products, the existing product information shall be amended (deletion of the text as appropriate) as provided below:
Danish: For lægemidler, der indeholder omega-3, skal den eksisterende produktinformation ændres (ved sletning af tekst) som følger:
English: For omega-3 containing medicinal products, the existing package leaflet shall be amended (deletion of the text as appropriate) as provided below:
Danish: For lægemidler, der indeholder omega-3, skal den nuværende indlægsseddel ændres (ved sletning af tekst) som følger:
English: Section 4.2: Posology and method of administration Information related to “secondary prevention after myocardial infarction” indication should be deleted: Post Myocardial Infarction
Danish: Oplysninger vedrørende indikationen "sekundær forebyggelse efter myokardieinfarkt" skal slettes: Efter myokardieinfarkt
English: The absolute bioavailability was 74%.
Danish: Den absolutte biotilgængelighed var 74 %.
English: The tablets should not be divided.
Danish: Tabletterne bør ikke deles.
English: Date of first authorisation: 20/05/2019
Danish: Dato for første markedsføringstilladelse: 20/05/2019
English: ATC vet code: QP53BE01.
Danish: ATCvet-kode: QP53BE01.
English: The periodic safety update report (PSUR) submissions shall be synchronised and submitted at the same frequency as for the reference product.
Danish: Indsendelser af de periodiske, opdaterede sikkerhedsindberetninger (PSUR) skal synkroniseres og ske med samme frekvens som for referenceproduktet.
English: Severe cases may require prolonged monthly treatments.
Danish: I alvorlige tilfælde kan det være nødvendigt at forlænge de månedlige behandlinger.
English: Wash hands after handling the product.
Danish: Vask hænder efter brug.
English: Afoxolaner MERIAL kills fleas within 8 hours and ticks within 48h.
Danish: Afoxolaner MERIAL dræber lopper inden for 8 timer og flåter inden for 48 timer.
English: Return the blister with the remaining chewable tablets into the carton.
Danish: Læg blisteret med resten af tabletterne tilbage i æsken.
English: Most reported adverse reactions were self-limiting and of short duration.
Danish: De fleste rapporterede bivirkninger var forbigående og kortvarige.
English: One treatment kills ticks for up to one month.
Danish: En behandling dræber flåter i op til en måned.
English: Method of administration:
Danish: Administrationsmåde:
English: Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency (http://www.ema.europa.eu).
Danish: Yderligere information om dette veterinærlægemiddel er tilgængelig på Det Europæiske Lægemiddelagenturs hjemmeside (http://www.ema.europa.eu)
English: The veterinary medicinal product is individually packaged in thermoformed laminated PVC blisters with paper-backed aluminium (Aclar/PVC/Alu).
Danish: Veterinærlægemidlet er pakket enkeltvis i termoformede, laminerede PVC blisterpakninger med papirbelagt aluminium (Aclar/PVC/Alu).
English: For dogs above 50 kg bodyweight, use an appropriate combination of chewable tablets of different/same strengths.
Danish: Til hunde som vejer over 50 kg anvendes en passende kombination af tyggetabletter af forskellig/samme styrke.
English: Further monthly administration of the product may be required based on clinical assessment and skin scrapings.
Danish: Det kan være nødvendigt at give yderligere månedlige behandlinger baseret på klinisk vurdering og hudskrab.
English: Bodyweight of dog (kg)
Danish: Hundens vægt (kg)
English: EU/2/19/240/001 EU/2/19/240/002 EU/2/19/240/003 EU/2/19/240/004 EU/2/19/240/005 EU/2/19/240/006 EU/2/19/240/007 EU/2/19/240/008 EU/2/19/240/009 EU/2/19/240/010 EU/2/19/240/011 EU/2/19/240/012 EU/2/19/240/013 EU/2/19/240/014
Danish: EU/2/19/240/001 EU/2/19/240/002 EU/2/19/240/003 EU/2/19/240/004 EU/2/19/240/005 EU/2/19/240/006 EU/2/19/240/007 EU/2/19/240/008 EU/2/19/240/009 EU/2/19/240/010 EU/2/19/240/011
English: This results in uncontrolled activity of the central nervous system and death of insects or acarines.
Danish: Dette resulterer i en ukontrolleret aktivitet i centralnervesystemet med deraf følgende drab af insekter eller mider.
English: 4 Chemin du Calquet 31000 Toulouse FRANCE
Danish: 4 Chemin du Calquet 31000 Toulouse Frankrig
English: Pharmacotherapeutic group: Ectoparasiticides for systemic use.
Danish: Farmakoterapeutisk gruppe: Ektoparasitære midler til systemisk brug.
English: No evidence of enterohepatic recycling has been observed.
Danish: Ingen tegn på enterohepatisk recirkulation er observeret.
English: After oral administration in dogs, afoxolaner was shown to have high systemic absorption following administration.
Danish: Efter oral administration til hund har afoxolaner vist at have høj systemisk absorption.
English: If the dog does not accept the tablets directly they may be administered with food.
Danish: Hvis hunden ikke accepterer tabletterne som de er, kan de gives sammen med foder.
English: As demodicosis is a multi-factorial disease, where possible, it is advisable to also treat any underlying disease appropriately.
Danish: Da demodecose er en multifaktuel sygdom, anbefales det at behandle underliggende sygdom på passende måde, hvor det er muligt.
English: In-vitro experiments demonstrated that P-glycoprotein efflux does not occur, confirming that afoxolaner is not a substrate for the P-glycoprotein transporters.
Danish: In-vitro-forsøg viste, at udstrømning af P-glykoprotein ikke finder sted, hvilket bekræfter at afoxolaner ikke er et substrat for P-glykoproteintransportører.
English: Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Danish: Afoxolaner er et insekticid og acaricid hørende til isoxazolinfamilien.
English: The product should be administered at a dose of 2.7-7 mg/kg bodyweight in accordance with the following table:
Danish: Præparatet skal gives i en dosis på 2,7-7 mg/kg kropsvægt i henhold til følgende tabel:
English: Use only according to the benefit-risk assessment by the responsible veterinarian.
Danish: Anvendes udelukkende efter den ansvarlige dyrlæges vurdering af benefit-risk-forholdet.
English: Strength and number of chewable tablets to be administered
Danish: Styrke og antal af tyggetabletter der skal gives
English: Monthly administration of the product until two negative skin scrapings are obtained one month apart.
Danish: Administrer præparatet en gang pr. måned, indtil der er opnået to negative hudskrab med en måneds mellemrum.
English: In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 2 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian.
Danish: Da der ikke foreligger data, skal behandling af hvalpe yngre end 8 uger og /eller hunde, som vejer under 2 kg, baseres på den ansvarlige dyrlæges vurdering af fordele og ulemper.
English: The safety of the veterinary medicinal product has not been established during pregnancy and lactation or in breeding dogs.
Danish: Veterinærlægemidlets sikkerhed er ikke fastslået under drægtighed og diegivning eller hos avlshunde.
English: Monthly intervals throughout the flea and/or tick seasons, based on local epidemiological situations.
Danish: En gang pr. måned i loppe- og/eller flåtsæsonen, baseret på den lokale epidemiologiske status.
English: No adverse reactions were observed in healthy Beagle puppies over 8 weeks of age when treated with 5 times the maximum dose repeated 6 times at intervals of 2-4 weeks.
Danish: Der blev ikke observeret bivirkninger hos raske beaglehvalpe, over 8 uger gamle, som blev behandlet med 5 gange den maksimale dosis 6 gentagne gange med 2-4 ugers mellemrum.
English: The mean maximum concentration (Cmax) was 1,655 ± 332 ng/ml in plasma at 2-4 hours (Tmax) after a 2.5 mg/kg afoxolaner dose.
Danish: Middel maksimal plasmakoncentration (Cmax) var 1,655 ± 332 ng/ml 2-4 timer (Tmax) efter administration af en dosis på 2,5 mg/kg afoxolaner.
English: The tablets are chewable and palatable to most dogs.
Danish: Tabletterne kan tygges og er velsmagende for de fleste hunde.
English: Afoxolaner distributes into tissues with a volume of distribution of 2.6 ± 0.6 l/kg and a systemic clearance value of 5.0 ± 1.2 ml/hr/kg.
Danish: Afoxolaner fordeles til væv med et fordelingsvolumen på 2,6 ± 0,6 l/kg og en systemisk clearance på 5,0 ± 1,2 ml/time/kg.
English: Each chewable tablet contains:
Danish: En tyggetablet indeholder:
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGE Carton
Danish: OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Æske
English: Laboratory studies in rats and rabbits have not produced any evidence of teratogenic effects, or any adverse effect on the reproductive capacity of males and females.
Danish: Laboratorieundersøgelser af rotter og kaniner har ikke afsløret teratogene virkninger eller nogen bivirkninger på reproduktionsevnen hos hanner og hunner.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the carton after EXP.
Danish: Brug ikke dette veterinærlægemiddel efter den udløbsdato, der står på den ydre emballage efter EXP. Udløbsdatoen refererer til den sidste dag i den pågældende måned.
English: common (more than 1 but less than 10 animals in 100 animals treated) uncommon (more than 1 but less than 10 animals in 1,000 animals treated) rare (more than 1 but less than 10 animals in 10,000 animals treated) very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Danish: Hyppigheden af bivirkninger er defineret som: - Meget almindelig (flere end 1 ud af 10 behandlede dyr, der viser bivirkninger i løbet af en behandling) - Almindelige (flere end 1, men færre end 10 dyr ud af 100 behandlede dyr) - Ualmindelige (flere end 1, men færre end 10 dyr ud af 1.000 behandlede dyr) - Sjældne (flere end 1, men færre end 10 dyr ud af 10.000 behandlede dyr) - Meget sjælden (færre end 1 dyr ud af 10.000 behandlede dyr, herunder isolerede rapporter).
English: Afoxolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes.
Danish: Afoxolaner virker ved at påvirke de ligand-styrede chloridkanaler, især de der styres af neurotransmitteren gamma-aminosmørsyre (GABA), hvorved de blokerer den præ- og postsynaptiske overførsel af chlorioner over cellemembraner.
English: Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance.
Danish: Lopper og flåter skal bide sig fast på værtsdyret og starte indtag af føde for at blive eksponeret for det aktive stof.
English: Afoxolaner MERIAL tablets are chewable and palatable to most dogs.
Danish: Afoxolaner MERIAL tabletter kan tygges og er velsmagende for de fleste hunde.
English: Parasites need to start feeding on the host to become exposed to afoxolaner; therefore the risk of the transmission of parasite borne diseases cannot be excluded.
Danish: Parasitter skal have startet indtag af føde fra værtsdyret for at blive eksponeret for afoxolaner; derfor kan risikoen for overførsel af parasitbårne lidelser ikke udelukkes.
English: The terminal plasma half-life is approximately 2 weeks in most dogs; however, half-life of afoxolaner can differ between dogs (e.g. in one study, t½ in Collies at 25 mg/kg bodyweight was up to 47.7 days) with no effect on safety.
Danish: Halveringstiden for afoxolaner kan imidlertid variere mellem hunde (f.eks. var t½ i ét studie op til 47,7 dage hos collier ved 25 mg/kg kropsvægt) uden at sikkerheden påvirkes.
English: The selective toxicity of afoxolaner between insect/acarines and mammals may be inferred by the differential sensitivity of the insect/acarines' GABA receptors versus mammalian receptors.
Danish: Afoxolaners selektive toksicitet over for insekter/mider i forhold til pattedyr kan skyldes forskel i GABA-receptorernes følsomhed hos insekter og mider i forhold til pattedyrs receptorer.