FrancophonIA/ELRC3.0 huggingface dataset:
English: Metformin 1000mg Tablet
Lithuanian: Metformino 1 000 mg Tabletė
English: Stada Arzneimittel Ag
Lithuanian: Stada Arzneimittel Ag Metformin Stada
English: Metformin 850mg Tablet
Lithuanian: Metformino 850 mg Tabletė
English: Ratiopharm Nederland B.V
Lithuanian: Ratiopharm Nederland B.V Metformine Hcl Ratiopharm
English: Ireland Merck Serono Ltd.
Lithuanian: Jungtinė Karalystė Merck Serono Ltd.
English: Metformin Hydrochloride 500mg Units
Lithuanian: Metformino hidrochlorido 500 mg Units
English: Poland Sandoz Gmbh
Lithuanian: Sandoz Gmbh
English: Germany Abz-Pharma Gmbh
Lithuanian: Abz-Pharma Gmbh
English: Metformin Hydrochloride 400mg Capsule, Glibenclamide 2.5mg Capsule
Lithuanian: Metformino hidrochlorido 400 mg Kapsulė, Glibenklamido 2,5 mg Kapsulė
English: Amneal Pharma Europe Limited Metformina Amneal
Lithuanian: Amneal Pharma Europe Limited
English: Finland Aurobindo Pharma (Malta) Limited Metformin Aurobindo
Lithuanian: Aurobindo Pharma Limited Metformin Aurobindo
English: Germany Aaa-Pharma Gmbh
Lithuanian: Aaa-Pharma Gmbh
English: Austria Hexal Pharma Gmbh
Lithuanian: Hexal Pharma Gmbh
English: Metformin Hydrochloride 500ml/5 Ml
Lithuanian: Metformino hidrochlorido 500 ml/5 Ml
English: Pinewood Laboratories Limited Metformin Hydrochloride Pinewood Laboratories
Lithuanian: Metformin Hydrochloride Pinewood Laboratories
English: Germany Biomo Pharma Gmbh
Lithuanian: Biomo Pharma Gmbh
English: Metformin Hydrochloride Generics [uk]
Lithuanian: Jungtinė Karalystė Generics [uk] Limited Metformin Hydrochloride Generics [uk]
English: Sandoz Ltd
Lithuanian: Jungtinė Karalystė Sandoz Ltd
English: Laboratórios Basi - Indústria Farmacêutica, S.A.
Lithuanian: Laboratórios BasiIndústria Farmacêutica, S.
English: United Consilient Health Limited
Lithuanian: Jungtinė Karalystė Consilient Health Limited Glucient Sr
English: Laboratórios Anova - Produtos Farmacêuticos Lda
Lithuanian: Laboratórios AnovaProdutos Farmacêuticos Lda
English: France Ranbaxy Pharmacie Generiques Metformine Ranbaxy
Lithuanian: Ranbaxy Pharmacie Generiques
English: Spain Almus Farmaceutica S.A
Lithuanian: Almus Farmaceutica S.A Metformina Almus
English: Metformin Hydrochloride 170mg/Ml
Lithuanian: Metformino hidrochlorido 170 mg/Ml
English: Germany Aliud Pharma Gmbh
Lithuanian: Aliud Pharma Gmbh
English: Greece Farmasyn S.A.
Lithuanian: Farmasyn S.A.
English: Metformin 500mg Tablet
Lithuanian: Metformino 500 mg Tabletė
English: Metformin Hydrochloride 100mg/ Ml
Lithuanian: Metformino hidrochlorido 100mg/Ml
English: United Tillomed Laboratories Ltd
Lithuanian: Jungtinė Karalystė Tillomed Laboratories Ltd Orabet
English: Germany Heumann Pharma Gmbh & Co. Generica Kg
Lithuanian: Heumann Pharma Gmbh & Co.
English: Focus Pharmaceuticals Limited Metformin Focus Pharmaceuticals
Lithuanian: Metformin Focus Pharmaceuticals
English: Metformin Wockhardt Uk
Lithuanian: Metformin Wockhardt Uk Ltd
English: Metformin Hydrochloride 1000mg Tablet, Linagliptin 2.5mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Linagliptino 2,5 mg Tabletė
English: Germany Axcount Generika Gmbh
Lithuanian: Axcount Generika Gmbh Metformin Axcount
English: Aurobindo Pharma Limited
Lithuanian: Aurobindo Pharma (Malta) Limited
English: Metformin Hydrochloride 850mg Tablet, Linagliptin 2.5mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Linagliptino 2,5 mg Tabletė
English: Metformin Hydrochloride 500mg/5 Ml
Lithuanian: Metformino hidrochlorido 500 mg/5 Ml
English: Metformin Hydrochloride 1g Tablet
Lithuanian: Metformino hidrochlorido 1 g Tabletė Plėvele dengta tabletė
English: Austria 1a Pharma Gmbh
Lithuanian: 1a Pharma Gmbh
English: Denmark Stada Arzneimittel Ag
Lithuanian: Stada Arzneimittel Ag Stadamet
English: Metformin Wockhardt Uk Ltd Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformin Wockhardt Uk Metformino hidrochlorido 850 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet, Sitagliptin 50mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Sitagliptino 50 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet, Empagliflozin 12.5mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Empagliflozino 12,5 mg Tabletė
English: Metformin Wockhardt Uk Ltd Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformin Wockhardt Uk Metformino hidrochlorido 500 mg Tabletė
English: Metformin Hydrochloride 1000mg
Lithuanian: Metformino hidrochlorido 1 000 mg Sachet
English: Metformin Hydrochloride 850mg Tablet, Empagliflozin 12.5mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Empagliflozino 12,5 mg Tabletė
English: Metformin Lindopharm Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformin Lindopharm Metformino hidrochlorido 500 mg Tabletė
English: Metformin Hydrochloride 850mg Tablet, Alogliptin 25mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Alogliptino 25 mg Tabletė
English: Slovakia Actavis Group Ptc Ehf.
Lithuanian: Jungtinė Karalystė Actavis Group Ptc Ehf.
English: Aurobindo Pharma (Malta) Limited Metformin Hydrochloride Aurobindo Pharma (Malta)
Lithuanian: Jungtinė Karalystė Aurobindo Pharma Limited Metformin Hydrochloride Aurobindo Pharma
English: Metformin Lindopharm Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformin Lindopharm Metformino hidrochlorido 850 mg Tabletė
English: Metformin Hydrochloride 850mg
Lithuanian: Metformino hidrochlorido 850 mg Sachet
English: Metformin Hydrochloride 850mg Tablet, Sitagliptin 50mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Sitagliptino 50 mg Tabletė
English: Germany Tad Pharma Gmbh
Lithuanian: Tad Pharma Gmbh
English: Germany Juta Pharma Gmbh
Lithuanian: Juta Pharma Gmbh
English: Germany Denk Pharma Gmbh & Co. Kg Metfo
Lithuanian: Denk Pharma Gmbh & Co.
English: Metformin Hydrochloride 1000mg Tablet, Dapagliflozin 5mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Dapagliflozino 5 mg Tabletė
English: Metformin Relonchem Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformin Relonchem Metformino hidrochlorido 850 mg Tabletė
English: Austria Stada Arzneimittel Gmbh
Lithuanian: Stada Arzneimittel Gmbh Metformin Stada
English: Metformin Hydrochloride 850mg Tablet, Dapagliflozin 5mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Dapagliflozino 5 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet, Glibenclamide 5mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Glibenklamido 5 mg Tabletė
English: Metformin Hydrochloride 850mg Tablet, Alogliptin 12.5mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Alogliptino 12,5 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet, Canagliflozin 50mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Kanagliflozino 50 mg Tabletė
English: Arrow Generics LimitedTransferred To Actavis Group Ptc Ehf
Lithuanian: Jungtinė Karalystė Arrow Generics LimitedTransferred To Actavis
English: Austria Merck Gesellschaft Mbh
Lithuanian: Merck Gesellschaft Mbh Glucophage
English: Metwest Pharmaceuticals Limited Metformin Metwest Pharmaceuticals
Lithuanian: Jungtinė Karalystė Metwest Pharmaceuticals Limited
English: Generics [uk] Limited
Lithuanian: Generics [uk] Limited Metnova
English: Metformin Hydrochloride 850mg Tablet, Empagliflozin 5mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Empagliflozino 5 mg Tabletė
English: Metformin Relonchem Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformin Relonchem Metformino hidrochlorido 500 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet, Empagliflozin 5mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Empagliflozino 5 mg Tabletė
English: Metformin Hcl Ratiopharm Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformin Hcl Ratiopharm Metformino hidrochlorido 500 mg Tabletė
English: Metformin Hydrochloride 400mg Tablet, Glibenclamide 2.5mg Tablet
Lithuanian: Metformino hidrochlorido 400 mg Tabletė, Glibenklamido 2,5 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet, Canagliflozin 150mg Tablet
Lithuanian: Metformino hidrochlorido 1 000 mg Tabletė, Kanagliflozino 150 mg Tabletė
English: Metformin Hydrochloride 850mg Tablet, Canagliflozin 50mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Kanagliflozino 50 mg Tabletė
English: Metformin Hydrochloride 1000mg Tablet Tablet
Lithuanian: Metformin Genericon Metformino hidrochlorido 1 000 mg Tabletė
English: Metformin Hcl Ratiopharm Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformin Hcl Ratiopharm Metformino hidrochlorido 850 mg Tabletė
English: Metformin Hydrochloride 2.5mg Tablet, Glibenclamide 500mg Tablet
Lithuanian: Metformino hidrochlorido 2,5 mg Tabletė, Glibenklamido 500 mg Tabletė
English: Metformin Hydrochloride 500mgg
Lithuanian: Metformino hidrochlorido 500 mg Plėvelė
English: Metformin Hydrochloride 400mg Tablet, Glibenclamide 5mg Tablet
Lithuanian: Metformino hidrochlorido 400 mg Tabletė, Glibenklamido 5 mg Tabletė
English: Metformina Mylan Generics Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformine Hcl Mylan Metformino hidrochlorido 500 mg Tabletė
English: Metformin Hydrochloride 850mg Tablet, Canagliflozin 150mg Tablet
Lithuanian: Metformino hidrochlorido 850 mg Tabletė, Kanagliflozino 150 mg Tabletė
English: Metformin Hydrochloride 500mg Tablet, Glibenclamide 2.5mg Tablet
Lithuanian: Metformino hidrochlorido 500 mg Tabletė, Glibenklamido 2,5 mg Tabletė
English: Metformin Hydrochloride 500mg Tablet, Glibenclamide 5mg Tablet
Lithuanian: Metformino hidrochlorido 500 mg Tabletė, Glibenklamido 5 mg Tabletė
English: Metformin Hcl Ratiopharm Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Lithuanian: Metformin Hcl Ratiopharm Metformino hidrochlorido 1 000 mg Tabletė
English: Estonia Sandoz Gmbh
Lithuanian: Sandoz Pharmaceuticals Gmbh
English: Metformin-Ratiopharm Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformin-Ratiopharm Metformino hidrochlorido 850 mg Tabletė
English: Metformin-Ratiopharm Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformin-Ratiopharm Metformino hidrochlorido 500 mg Tabletė
English: Metformin Crescent Pharma Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformin Eql Pharma Metformino hidrochlorido 500 mg Tabletė
English: Metformin Hydrochloride Tillomed Laboratories
Lithuanian: Jungtinė Karalystė Tillomed Laboratories Ltd Metformin Hydrochloride Tillomed Laboratories
English: Metformin Crescent Pharma Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformina Pensa Pharma Metformino hidrochlorido 850 mg Tabletė
English: Metformina Mylan Generics Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformine Hcl Mylan Metformino hidrochlorido 850 mg Tabletė
English: Metformin Hydrochloride 500mg
Lithuanian: Metformino hidrochlorido 500 mg Sachet
English: United Kingdom
Lithuanian: Nyderlandai
English: Medley Pharma Limited
Lithuanian: Rosemont Pharmaceuticals Limited
English: Estonia Wörwag Pharma Gmbh & Co. Kg Metfogamma
Lithuanian: Dexcel Pharma Gmbh Metformin Atid
English: Metformina Mylan Generics Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Lithuanian: Metformine Hcl Mylan Metformino hidrochlorido 1 000 mg Tabletė
English: Metformin Ratiopharm Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformin Ratiopharm Metformino hidrochlorido 850 mg Tabletė
English: Metformin Ratiopharm Metformin Hydrochloride 500mg Tablet
Lithuanian: Metformine Ratiopharm Metformino hidrochlorido 500 mg Tabletė
English: Denmark Aurobindo Pharma Limited
Lithuanian: Metformin Hydrochloride Aurobindo Pharma (Malta) Limited
English: Metformin Hydrochloride 850mgg
Lithuanian: Metformino hidrochlorido 850 mg Tabletė
English: Metformin 850mg Film
Lithuanian: Metformino 850 mg Plėvelė
English: Germany Sandoz Pharmaceuticals Gmbh Metformin Sandoz
Lithuanian: Arcana Arzneimittel Gmbh Metformin Arcana
English: Metformine Arrow Generiques Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Lithuanian: Metformine Arrow Lab Metformino hidrochlorido 1 000 mg Tabletė
English: Germany Aurobindo Pharma Gmbh
Lithuanian: Aurobindo Pharma Gmbh Metformin Aurobindo
English: France Mylan S.A.S
Lithuanian: Mylan S.A.
English: Metformine Ratiopharm Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformine Ratiopharm Metformino hidrochlorido 850 mg Tabletė
English: Metformin Ratiopharm Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Lithuanian: Metformin Ratiopharm Metformino hidrochlorido 1 000 mg Tabletė
English: Metformin Hcl Plus Pharmacie Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Lithuanian: Metformine Mylan Pharma Metformino hidrochlorido 1 000 mg Tabletė
English: Metformina Ratiopharm Metformin Hydrochloride 850mg Tablet
Lithuanian: Metformina Ratiopharm Metformino hidrochlorido 850 mg Tabletė
English: Wörwag Pharma Gmbh & Co. Kg Metfogamma
Lithuanian: Wörwag Pharma Gmbh & Co.
English: Metformine Ratiopharm Metformin Hydrochloride 1000mg Tablet Film-Coated Tablet
Lithuanian: Metformine Ratiopharm Metformino hidrochlorido 1 000 mg Tabletė
English: Norway Rosemont Pharmaceuticals Limited Metformin Rosemont
Lithuanian: Jungtinė Karalystė Rosemont Pharmaceuticals Limited
English: Some patients were treated for up to five and a half years.
Lithuanian: Kai kurie pacientai buvo gydomi iki penkerių su puse metų.
English: • Gaucher disease;
Lithuanian: • Gošė liga;
English: Other information about Zavesca:
Lithuanian: Kita informacija apie Zavesca:
English: Zavesca is intended for long-term use.
Lithuanian: Zavesca skirtas ilgalaikiam vartojimui.
English: The CHMP decided that Zavesca's benefits are greater than its risks and recommended that it be given marketing authorisation.
Lithuanian: CHMP nusprendė, kad Zavesca nauda yra didesnė už jo keliamą riziką, ir rekomendavo suteikti jo rinkodaros leidimą.
English: There were also small improvements in blood counts: on average, the levels of haemoglobin increased by 0.26 g per decilitre and platelet counts increased by 8.29 million per millilitre.
Lithuanian: Taip pat šiek tiek padidėjo kraujo kūnelių kiekis: pastebėtas vidutinis hemoglobino koncentracijos padidėjimas 0,26 g viename decilitre ir vidutinis trombocitų skaičiaus padidėjimas 8,29 milijonų viename mililitre.
English: The main part of the study lasted for a year, but 13 patients carried on receiving the medicine for a further two years.
Lithuanian: Šis tyrimas truko vienerius metus, tačiau 13 pacientų šiuo vaistu buvo gydomi dar 2 metus.
English: EPAR summary for the public miglustat
Lithuanian: Europos santrauka plačiajai visuomenei miglustatas
English: The company also presented the results of a survey of 66 patients treated with Zavesca.
Lithuanian: Bendrovė taip pat pateikė 66 Zavesca gydytų pacientų apklausos rezultatus.
English: Why has Zavesca been approved?
Lithuanian: Kodėl Zavesca buvo patvirtintas?
English: The full EPAR for Zavesca can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Lithuanian: Išsamų Zavesca EPAR rasite agentūros interneto svetainėje adresu: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
English: What is the risk associated with Zavesca?
Lithuanian: Kokia rizika siejama su Zavesca vartojimu?
English: As the company had supplied the additional information requested, the exceptional circumstances ended on 23 August 2012.
Lithuanian: Bendrovei pateikus reikalaujamą papildomą informaciją, 2012 m.
English: What benefit has Zavesca shown during the studies?
Lithuanian: Kokia Zavesca nauda nustatyta tyrimuose?
English: For more information about treatment with Zavesca, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Lithuanian: Daugiau informacijos apie gydymą Zavesca rasite pakuotės lapelyje (taip pat EPAR dalis) arba teiraukitės savo gydytojo ar vaistininko.
English: What is Zavesca?
Lithuanian: Kas yra Zavesca?
English: The main measure of effectiveness was the change in the speed at which the patients made saccadic horizontal eye movements after a year, but the study also looked at other neurological symptoms such as the patients' ability to swallow and their intellectual function.
Lithuanian: Pagrindinis vaisto veiksmingumo rodiklis buvo per metus pakitęs pacientų horizontalių sakadinių akies judesių greitis, tačiau tyrime taip pat buvo vertinami kiti neurologiniai simptomai, pvz., pacientų gebėjimas ryti ir jų protinė funkcija.
English: The study compared the effects of adding Zavesca to standard care with the effects of standard care alone.
Lithuanian: Tyrime su standartiniu gydymu skiriamo Zavesca poveikis buvo lyginamas su vien standartinio gydymo poveikiu.
English: The summaries of the opinions of the Committee for Orphan Medicinal Products for Zavesca on the Agency's website ema.europa.eu/Find medicine/Human medicines/Rare disease designations:
Lithuanian: Retųjų vaistų komiteto nuomonių apie Zavesca santraukas rasite agentūros interneto svetainėje: ema.europa.eu/Find medicine/Human medicines/Rare disease designations.
English: These include loss of co-ordination, problems with ‘saccadic' (rapid) eye movements that can lead to impaired vision, delayed development, difficulty swallowing, decreased muscle tone, fits and learning difficulties.
Lithuanian: Tokie simptomai taikoordinacijos sutrikimas, sakadiniai (greiti) akių judesiai, dėl kurių gali sutrikti regėjimas, sulėtėjęs vystymasis, rijimo sutrikimai, sumažėjęs raumenų tonusas, priepuoliai ir mokymosi sunkumai.
English: For the full list of all side effects reported with Zavesca, see the package leaflet.
Lithuanian: Išsamų visų šalutinių reiškinių, apie kuriuos pranešta gydant Zavesca, sąrašą galima rasti pakuotės lapelyje.
English: Zavesca is used to treat the neurological symptoms of the disease (symptoms affecting the brain and nerves).
Lithuanian: Zavesca skiriamas neurologiniams ligos simptomams (pasireiškiantiems smegenyse ir nervuose) malšinti.
English: This enzyme is involved in the first step of the production of glycosphingolipids.
Lithuanian: Šis fermentas dalyvauja pirmame glikosfingolipidų gamybos etape.
English: The European Commission granted a marketing authorisation valid throughout the European Union for Zavesca on 20 November 2002.
Lithuanian: suteikė visoje Europos Sąjungoje galiojantį Zavesca rinkodaros leidimą.
English: The study looked at the effect of Zavesca on the size of the liver and spleen, and at blood counts, such as the levels of haemoglobin (a protein found in red blood cells that carries oxygen around the body) and platelets (components that help the blood to clot).
Lithuanian: Tyrime buvo vertinama, ar Zavesca turi įtakos ligos pažeistų organų, pavyzdžiui, kepenų ar blužnies, dydžiui ir kraujo parametrams, pavyzdžiui, hemoglobino (raudonųjų kraujo kūnelių baltymo, kuris perneša deguonį organizme) ir trombocitų (skatinančių kraujo krešėjimą) koncentracijoms.
English: Zavesca must not be used in people who are hypersensitive (allergic) to miglustat or any of the other ingredients.
Lithuanian: Zavesca negalima skirti esant padidėjusiam jautrumui (alergijai) miglustatui arba kitoms pagalbinėms medžiagoms.
English: Treatment with Zavesca should be started and monitored by doctors who are experienced in the management of Gaucher or Niemann-Pick type C disease.
Lithuanian: Gydymą Zavesca turi pradėti ir stebėti gydytojas, turintis Gošė arba C tipo Nimano-Piko ligos gydymo patirties.
English: For Niemann-Pick type C disease, Zavesca was studied in one main study involving 31 patients, 12 of whom were less than 12 years old.
Lithuanian: Zavesca poveikiui C tipo Nimano-Piko liga sergantiems pacientams ištirti atliktas vienas pagrindinis tyrimas, kuriame dalyvavo 31 pacientas, iš kurių 12 buvo jaunesni negu 12 metų amžiaus.
English: The benefits of Zavesca were maintained over three years of continuous treatment.
Lithuanian: Taikant nuolatinį gydymą Zavesca poveikis išsilaikė daugiau kaip trejus metus.
English: The most common side effects with Zavesca (seen in more than 1 patient in 10) are weight loss, decreased appetite, tremor (shaking), diarrhoea, flatulence (gas) and abdominal pain (stomach ache).
Lithuanian: Dažniausi Zavesca šalutiniai reiškiniai (pastebėti daugiau nei 1 iš 10 pacientų) yra svorio mažėjimas, sumažėjęs apetitas, drebulys, viduriavimas, vidurių pūtimas ir pilvo (skrandžio) skausmas.
English: Zavesca was originally authorised under ‘exceptional circumstances' because, as the diseases are rare, limited information was available at the time of approval.
Lithuanian: Iš pradžių Zavesca rinkodaros leidimas suteiktas išimtinėmis sąlygomis, kadangi dėl ligų retumo buvo neįmanoma gauti visos reikiamos informacijos apie šį vaistą.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Zavesca.
Lithuanian: Šis dokumentas yra Zavesca Europos viešo vertinimo protokolo (EPAR) santrauka. Jame paaiškinama, kaip Žmonėms skirtų vaistinių preparatų komitetas (CHMP) įvertinęs vaistą priėmė nuomonę, kuria rekomenduoja suteikti Zavesca rinkodaros leidimą ir pateikia jo vartojimo rekomendacijas.
English: Zavesca is used to treat two inherited diseases that affect the way the body handles fats.
Lithuanian: Zavesca skirtas dviem paveldimoms ligoms, kurios apsunkina riebalų įsisavinimą organizme, gydyti.
English: This is expected to slow down or prevent the development of the symptoms of type 1 Gaucher disease and to reduce the symptoms of Niemann-Pick type C disease.
Lithuanian: Manoma, kad tai sulėtina I tipo Gošė ligos simptomų atsiradimą arba neleidžia jiems atsirasti ir palengvina C tipo Nimano-Piko ligos simptomus.
English: • Niemann-Pick type C disease.
Lithuanian: • C tipo Nimano-Piko liga.
English: Zavesca is used in patients who cannot receive the standard treatment of enzyme replacement therapy (ERT);
Lithuanian: Zavesca skiriamas pacientams, kuriems negalima taikyti standartinės pakaitinės fermentų terapijos;
English: • patients of all ages with Niemann-Pick type C disease, a potentially fatal disease in which glycosphingolipids build up within cells in the brain and elsewhere in the body.
Lithuanian: • pacientams, sergantiems C tipo Nimano-Piko (Niemann-Pick) liga, kuri gali būti mirtina, kadangi glikosfingolipidai kaupiasi smegenų ir kitų organų ląstelėse.
English: By preventing the enzyme from working, miglustat can reduce the production of glycosphingolipids in cells.
Lithuanian: Neleisdamas fermentui veikti miglustatas gali sumažinti ląstelėse pagaminamų glikosfingolipidų kiekį.
English: A lower dose should be used in patients with reduced kidney function.
Lithuanian: Inkstų veiklos sutrikimų turintiems pacientams reikia skirti mažesnę vaisto dozę.
English: The recommended starting dose for type 1 Gaucher disease is one capsule three times a day.
Lithuanian: Rekomenduojama pradinė vaisto dozė I tipo Gošė liga sergantiems pacientams yra po vieną kapsulę tris kartus per parą.
English: Patients with this disease lack an enzyme called glucocerebrosidase, which results in a glycosphingolipid called glucosylceramide building up in different parts of the body, such as the spleen, liver and bones.
Lithuanian: Šia liga sergančių pacientų organizme trūksta fermento gliukocerebrozidazės, dėl to įvairiuose organuose, pvz., blužnyje, kepenyse ir kauluose, pradeda kauptis gliukozilseramidas glikosfingolipidas.
English: It is available as capsules (100 mg).
Lithuanian: Zavesca - tai vaistas, kurio sudėtyje yra veikliosios medžiagos miglustato. Jis tiekiamas kapsulėmis (po 100 mg).
English: The dose should also be reduced temporarily in patients who develop diarrhoea.
Lithuanian: Dozę reikia laikinai sumažinti, jei pacientui pasireiškia viduriavimas.
English: The survey showed that Zavesca led to a stabilisation or a decrease in the rate at which symptoms got worse in about three-quarters of the patients.
Lithuanian: Apklausa parodė, kad maždaug trims ketvirtadaliams pacientų Zavesca sustabdė arba sumažino ligos simptomų sunkėjimą.