FrancophonIA/ELRC3.0 huggingface dataset:
English: Infections and infestations
Slovenian: Razvoj zarodka in plodu
English: In Studies ESTEEM 1 and ESTEEM 2, significant improvements (reductions) in nail psoriasis, as measured by the mean percent change in Nail Psoriasis Severity Index (NAPSI) from baseline, were observed in patients receiving apremilast compared to placebo-treated patients at week 16 (p< 0.0001 and p=0.0052, respectively).
Slovenian: izmerjene s povprečno odstotno spremembo indeksa izraženosti psoriaze nohtov (Nail Psoriasis Severity Index (NAPSI)) od izhodišča (p< 0,0001 oziroma p=0,0052).
English: • nausea
Slovenian: • bruhanje,
English: Skin and subcutaneous tissue disorders
Slovenian: Bolezni kože in podkožja občasni izpuščaj urtikarija neznana angioedem
English: Otezla contains lactose
Slovenian: Zdravilo Otezla vsebuje laktozo
English: Diarrhoea* Nausea*
Slovenian: Bolezni prebavil zelo pogosti driska*
English: • diarrhoea
Slovenian: • driska,
English: Dyspepsia
Slovenian: Odmerjanje
English: General disorders and administration site conditions
Slovenian: Splošne težave in spremembe na mestu aplikacije pogosti utrujenost
English: Protect other people
Slovenian: Zaščitite druge ljudi
English: These reactions have often been transitory.
Slovenian: Ti učinki so bili pogosto prehodni.
English: • if they drink alcohol
Slovenian: • ki pijejo alkohol,
English: Then continue your treatment as before.
Slovenian: Nadaljujte z zdravljenjem tako, kot prej.
English: Assessed using a non-inferiority margin of 10%.
Slovenian: Ocenjeno z uporabo meje neinferiornosti 10 %.
English: This helps maintain the number of CD4 cells in your blood.
Slovenian: To pomaga ohranjati število celic CD4 v vaši krvi.
English: → Tell your doctor immediately.
Slovenian: → Takoj obvestite svojega zdravnika.
English: Individual components have been investigated in adolescents (12 to 17 years).
Slovenian: Posamezne komponente so raziskovali pri mladostnikih (starih od 12 do 17 let).
English: → If you think this applies to you, tell your doctor.
Slovenian: → Če menite, da to velja za vas, povejte svojemu zdravniku.
English: The clinical relevance of these findings is unknown.
Slovenian: Klinična pomembnost teh ugotovitev ni znana.
English: Use in adolescents
Slovenian: Uporaba pri mladostnikih
English: This medicine is not for use in children under 12 years of age, because it has not been studied in these patients.
Slovenian: Otroci To zdravilo ni namenjeno otrokom, mlajšim od 12 let, ker njegova uporaba pri teh bolnikih ni bila raziskana.
English: Your doctor will monitor the effectiveness of your treatment.
Slovenian: Zdravnik bo spremljal učinkovitost vašega zdravljenja.
English: • weakness beginning in the hands and feet and moving up towards the trunk of the body.
Slovenian: • oslabelost, ki se začne v rokah in stopalih in se širi navzgor proti trupu
English: If you miss a dose, take it as soon as you remember.
Slovenian: Če ste pozabili na odmerek, ga vzemite, kakor hitro se spomnite.
English: Symptoms may include:
Slovenian: Simptomi lahko vključujejo:
English: You need to be aware of the extra risks:
Slovenian: Zavedati se morate, da je tveganje večje:
English: • if you have moderate or severe liver disease
Slovenian: • če imate zmerno ali hudo bolezen jeter
English: Tell your doctor if you are taking any of the medicines in the following list:
Slovenian: Povejte svojemu zdravniku, če jemljete katero od zdravil z naslednjega seznama:
English: A similar effect was not seen in rats even at very high systemic exposure.
Slovenian: Pri podganah podobnega učinka niso opazili, tudi pri zelo visoki sistemski izpostavljenosti ne.
English: Effect of human serum
Slovenian: Vpliv humanega seruma
English: Gender Male Female Race White African-American/African Heritage/Other Age (years)
Slovenian: Spol moški ženske Rasa belci afroameričani/afriško poreklo/drugo Starost (leta)
English: N = Number of subjects in each treatment group
Slovenian: N = število preiskovancev v vsaki terapevtski skupini.
English: • The recommended dose of Dovato is one tablet once a day.
Slovenian: • Priporočeni odmerek zdravila Dovato je ena tableta enkrat na dan.
English: Do not take Dovato:
Slovenian: Ne jemljite zdravila Dovato:
English: If you are pregnant, think you may be pregnant, or if you are planning to have a baby:
Slovenian: Če ste noseči, mislite, da bi lahko bili noseči ali načrtujete zanositev:
English: Such infections may have been “silent” and not detected by the weak immune system before treatment was started.
Slovenian: Takšne okužbe lahko potekajo »tiho« in jih oslabljeni imunski sistem pred začetkom zdravljenja ne zazna.
English: The absolute bioavailability of oral lamivudine in adults is approximately 80-85%.
Slovenian: Absolutna biološka razpoložljivost lamivudina po peroralnem dajanju pri odraslih znaša približno 80 - 85 %.
English: Like all medicines, this medicine can cause side effects, although not everybody gets them, so it is very important to talk to your doctor about any changes in your health.
Slovenian: Kot vsa zdravila, ima lahko tudi to zdravilo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih, zato je zelo pomembno, da se z zdravnikom pogovorite o vseh spremembah, ki jih opazite glede vašega zdravja.
English: Component of a multipack, can't be sold separately.
Slovenian: Sestavni del pakiranja po več enot, ki se ne prodaja ločeno.
English: CD4 cells are a type of white blood cells that are important in helping your body to fight infection.
Slovenian: Celice CD4 so vrsta belih krvnih celic, ki so v telesu pomembne za boj proti okužbi.
English: Reference should be made to treatment guidelines.
Slovenian: Upoštevati je treba smernice za zdravljenje.
English: Pooled analysis also stratified by study.
Slovenian: Združena analiza je bila stratificirana tudi glede na študijo.
English: Pharmacokinetic parameters are comparable to those reported in adults.
Slovenian: Farmakokinetični parametri so primerljivi s tistimi pri odraslih.
English: If possible, show them the Dovato pack.
Slovenian: Po možnosti jima pokažite ovojnino zdravila Dovato.
English: Do not stop taking Dovato without consulting your doctor, as this may harm you and your unborn child.
Slovenian: Brez posvetovanja z zdravnikom ne prenehajte jemati zdravila Dovato, ker to lahko škoduje vam in vašemu nerojenemu otroku.
English: • abnormal dreams
Slovenian: • nenormalne sanje
English: The table should not be considered exhaustive but is representative of the classes studied.
Slovenian: Preglednice ne gre jemati, kot da je dokončna, je pa reprezentativna za preučevane skupine.
English: Dovato should be used during pregnancy only if the expected benefit justifies the potential risk to the foetus.
Slovenian: Zdravilo Dovato se lahko uporablja v nosečnosti samo, če pričakovana korist upravičuje morebitno tveganje za plod.
English: Frequencies are defined as very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Slovenian: Pogostnosti so opredeljene kot: zelo pogosti (1/10), pogosti (1/100 do <1/10), občasni (1/1.000 do <1/100), redki (1/10.000 do <1/1.000), zelo redki (<1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: Not everyone responds to treatment with Dovato in the same way.
Slovenian: Na zdravljenje z zdravilom Dovato se vsi ne odzivajo enako.
English: Transmission of HIV
Slovenian: Prenašanje virusa HIV
English: Interaction geometric mean change (%)
Slovenian: Geometrijsko povprečje spremembe (%)
English: Double blind therapy will continue up to week 96, followed by open label therapy up to week 148.
Slovenian: Dvojno slepo zdravljenje se bo nadaljevalo do 96. tedna, sledilo bo odprto zdravljenje do 148. tedna.
English: → Don't drive or operate machinery unless you are sure you're not affected.
Slovenian: → Ne vozite ali upravljajte strojev, če niste prepričani, da zdravilo na vas tako ne vpliva.
English: Swallow the tablet with some liquid.
Slovenian: Tableto pogoltnite z nekaj tekočine.
English: If you get any symptoms of infection or if you notice any of the symptoms above:
Slovenian: Če se pri vas pojavijo simptomi okužbe in vnetja ali če opazite katerega od zgoraj naštetih simptomov:
English: Your doctor may decide to adjust your dose or that you need extra check ups.
Slovenian: Zdravnik se lahko odloči, da vam prilagodi odmerek ali da potrebujete dodatne kontrolne preglede.
English: What you need to know before you take Dovato 3.
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Dovato 3.
English: • if you have ever had liver disease, including hepatitis B or C (if you have hepatitis B infection, don't stop Dovato without your doctor's advice, as your hepatitis may come back)
Slovenian: • če ste kdaj imeli bolezen jeter, vključno s hepatitisom B ali C (če imate okužbo s hepatitisom B, ne prenehajte jemati zdravila Dovato brez posveta z vašim zdravnikom, saj se lahko hepatitis ponovi)
English: Dovato does not cure HIV infection; it keeps the amount of virus in your body at a low level.
Slovenian: Zdravilo Dovato ne ozdravi okužbe z virusom HIV, ampak vzdržuje količino virusa v telesu na nizki ravni.
English: You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.
Slovenian: O neželenih učinkih lahko poročate tudi neposredno na nacionalni center za poročanje, ki je naveden v Prilogi V. S tem, ko poročate o neželenih učinkih, lahko prispevate k zagotovitvi več informacij o varnosti tega zdravila
English: → Read the information ‘Allergic reactions' in section 4 of this leaflet.
Slovenian: → Preberite odstavek »Alergijske reakcije« v poglavju 4 tega navodila.
English: Any inflammatory symptoms should be evaluated and treatment instituted when necessary.
Slovenian: Kakršnekoli vnetne simptome je treba oceniti in uvesti zdravljenje, kadar je potrebno.
English: • depression (feelings of deep sadness and unworthiness)
Slovenian: • depresija (občutki globoke žalosti in nevrednosti)
English: • rifampicin, to treat tuberculosis (TB) and other bacterial infections
Slovenian: • rifampicin, za zdravljenje tuberkuloze (TB) in drugih bakterijskih okužb
English: • swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing
Slovenian: • oteklina, včasih obraza ali ust (angioedem), ki povzroča oteženo dihanje
English: • This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodiumfree'.
Slovenian: • To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na tableto, kar v bistvu pomeni “brez natrija”.
English: The symptoms of autoimmune disorders may develop many months after you start taking medicine to treat your HIV infection.
Slovenian: Simptomi avtoimunih bolezni se lahko pojavijo več mesecev po tem, ko ste začeli jemati zdravila za zdravljenje okužbe z virusom HIV.
English: The observed lamivudine half-life of elimination is 18 to 19 hours.
Slovenian: Opazovani eliminacijski razpolovni čas lamivudina znaša od 18 do 19 ur.
English: If you have taken Dovato during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child.
Slovenian: Če ste zdravilo Dovato jemali med nosečnostjo, vas lahko zdravnik naroči na redne preiskave krvi in druge diagnostične preiskave, da bo spremljal razvoj vašega otroka.
English: What Dovato is and what it is used for 2.
Slovenian: Kaj je zdravilo Dovato in za kaj ga uporabljamo 2.
English: If you get any of the following symptoms:
Slovenian: Če se vam pojavi kateri od naslednjih simptomov:
English: Clinically significant interaction unlikely.
Slovenian: Klinično pomembna interakcija ni verjetna.
English: • if they have been taking combination therapy for a long time
Slovenian: • ki jemljejo kombinirano terapijo dalj časa,
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Dovato in one or more subsets of the paediatric population in the treatment of HIV infection.
Slovenian: Evropska agencija za zdravila (EMA) je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Dovato za eno ali več podskupin pediatrične populacije za zdravljenje okužbe s HIV.
English: Women who are HIV-positive must not breast feed because HIV infection can be passed on to the baby in breast milk.
Slovenian: Ženske, ki so HIV-pozitivne, ne smejo dojiti, saj se okužba z virusom HIV lahko z materinim mlekom prenese na otroka.
English: It is recommended that HIV infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.
Slovenian: Priporočljivo je, da ženske, okužene z virusom HIV, v nobenem primeru ne dojijo svojih otrok, da bi se izognile prenosu virusa HIV.
English: Effects on electrocardiogram
Slovenian: Vpliv na elektrokardiogram
English: • if you are allergic (hypersensitive) to dolutegravir or lamivudine or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični (preobčutljivi) na dolutegravir ali lamivudin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: The most frequently reported adverse reactions are headache (3%), diarrhoea (2%), nausea (2%) and insomnia (2%).
Slovenian: Najpogosteje poročani neželeni učinki so bili glavobol (3 %), diareja (2 %), navzea (2 %) in nespečnost (2
English: Signs of osteonecrosis include:
Slovenian: Znaki osteonekroze so:
English: These changes are not clinically significant.
Slovenian: Te spremembe niso klinično pomembne.
English: The safety and efficacy of Dovato in children aged less than 12 years or weighing less than 40 kg have not been established.
Slovenian: Varnost in učinkovitost zdravila Dovato pri otrocih, mlajših od 12 let ali ki tehtajo manj kot 40 kg, nista bili dokazani.
English: Stopping Dovato can affect your health and how future treatment works.
Slovenian: Prenehanje jemanja zdravila Dovato lahko vpliva na vaše zdravje in na to, kako bodo delovala prihodnja zdravljenja.
English: There are limited data available on the use of Dovato in patients aged 65 years and over.
Slovenian: Na voljo so omejeni podatki o uporabi zdravila Dovato pri bolnikih, starih 65 let ali več.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant product information for these medicinal products.
Slovenian: V primeru sočasnega protiretrovirusnega zdravljenja hepatitisa B ali C upoštevajte tudi relevantne informacije o zdravilu za ta zdravila.
English: HIV infection is spread by sexual contact with someone who has the infection or by transfer of infected blood (for example, by sharing injection needles).
Slovenian: Okužba s HIV se prenaša s spolnim stikom z nekom, ki ima okužbo, ali z okuženo krvjo (na primer s souporabo injekcijskih igel).
English: Dovato has no or negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo Dovato nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: The frequency category of rare was estimated based on post-marketing reports.
Slovenian: Kategorija pogostnosti "redki" je ocenjena na podlagi poročil po prihodu zdravila na trg.
English: A similar study was not conducted with lamivudine.
Slovenian: Podobnih študij z lamivudinom niso izvajali.
English: • difficulty sleeping (insomnia)
Slovenian: • težave s spanjem (nespečnost)
English: Established and theoretical interactions with selected antiretrovirals and non-antiretroviral medicinal products are listed in Table 1.
Slovenian: Ugotovljene in hipotetične interakcije z izbranimi protiretrovirusnimi in ne-protiretrovirusnimi zdravili so navedene v Preglednici 1.
English: • if they are also taking anti-inflammatory medicines called corticosteroids
Slovenian: • ki obenem jemljejo protivnetna zdravila, imenovana kortikosteroidi,
English: • palpitations (rapid or irregular heartbeat) or tremor
Slovenian: • palpitacije (hiter ali nepravilen srčni utrip) ali tremor
English: • liver failure (signs may include yellowing of the skin and the whites of the eyes or unusually dark urine)
Slovenian: • odpoved jeter (znaki lahko vključujejo porumenelost kože in beločnic ali nenavadno temen urin)
English: If you forget to take Dovato
Slovenian: Če ste pozabili vzeti zdravilo Dovato
English: ViiV Healthcare BV Huis ter Heideweg 62 3705 LZ Zeist Netherlands
Slovenian: ViiV Healthcare BV Huis ter Heideweg 62 3705 LZ Zeist Nizozemska
English: This is an uncommon reaction (may affect up to 1 in 100 people) in people taking dolutegravir.
Slovenian: To je občasna reakcija (pojavi se lahko pri največ 1 od 100 bolnikov) pri bolnikih, ki jemljejo dolutegravir.
English: For lipids, there is in some cases evidence for a treatment effect, while for weight gain there is no strong evidence relating this to any particular treatment.
Slovenian: Pri lipidih v nekaterih primerih obstajajo dokazi, da gre za učinek zdravljenja, medtem ko za povečanje telesne mase ni trdnih dokazov, ki bi ga povezovali s katerim koli določenim zdravljenjem.
English: • emtricitabine, etravirine, efavirenz, nevirapine or tipranavir/ritonavir, to treat HIV infection
Slovenian: • emtricitabin, etravirin, efavirenz, nevirapin ali tipranavir/ritonavir, za zdravljenje okužb z virusom HIV
English: The changes are not considered to be clinically relevant and do not reflect a change in glomerular filtration rate.
Slovenian: Te spremembe niso klinično pomembne in ne odražajo spremembe v hitrosti glomerulne filtracije.
English: Dovato can also affect how some other medicines work.
Slovenian: Zdravilo Dovato lahko vpliva tudi na delovanje drugih zdravil.
English: A large amount of data on the use of lamivudine in pregnant women (more than 3000 outcomes from first trimester) indicates no malformative toxicity.
Slovenian: Velika količina podatkov o uporabi lamivudina pri nosečnicah (več kot 3000 primerov izpostavljenosti v prvem trimesečju) ne nakazuje malformacijske toksičnosti.
English: arthralgia, muscle disorders (including myalgia)
Slovenian: artralgija, mišične okvare (vključno z mialgijo)
English: These changes are linked to the inhibiting effect of dolutegravir on renal tubular transporters of creatinine.
Slovenian: Te spremembe so povezane z zaviralnim učinkom dolutegravirja na ledvične tubularne kreatininske prenašalce.
English: Antihistamines (histamine H2 receptor antagonists) Ranitidine
Slovenian: Antihistaminiki ( antagonisti histaminskega receptorja H2) ranitidin
English: Dovato can be taken with or without food (see section 5.2).
Slovenian: Zdravilo Dovato se lahko jemlje s hrano ali brez nje (glejte poglavje 5.2).
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART.
Slovenian: Opisani so bili primeri osteonekroze, zlasti pri bolnikih s splošno znanimi dejavniki tveganja, napredovano boleznijo HIV ali dolgotrajno izpostavljenostjo CART.
English: Sorbitol solution (3.2 g, 10.2 g, 13.4 g)/Lamivudine
Slovenian: Sorbitol raztopina sorbitola (3,2 g, 10,2 g, 13,4 g)/lamivudin
English: Symptoms usually include fever, plus some of the following:
Slovenian: Simptomi običajno vključujejo povišano telesno temperaturo in še katerega od naslednjih:
English: • aches and pains in the joints (especially in the hip, knee or shoulder)
Slovenian: • trganje in bolečine v sklepih (posebej v kolku, kolenu ali rami)
English: The effect of prolonged daily treatment with high doses of dolutegravir has been evaluated in repeat oral dose toxicity studies in rats (up to 26 weeks) and in monkeys (up to 38 weeks).
Slovenian: Vpliv dolgotrajnega vsakodnevnega zdravljenja z velikimi odmerki dolutegravirja so ocenili v študijah toksičnosti ponavljajočih se peroralnih odmerkov na podganah (do 26 tednov) in opicah (do 38 tednov).
English: Your doctor may decide to carry out tests to check your liver, kidneys or blood, and may tell you to stop taking Dovato.
Slovenian: Zdravnik se lahko odloči, da pri vas opravi teste za pregled jeter, ledvic ali krvi in vam naroči, da prenehate z jemanjem zdravila Dovato.
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: • na zahtevo Evropske agencije za zdravila; • ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: The frequency of this is unknown (see section 4.4).
Slovenian: Pogostnost primerov ni znana (glejte poglavje 4.4).
English: Very rare side effects that may show up in blood tests are: • a failure of the bone marrow to produce new red blood cells (pure red cell aplasia).
Slovenian: Zelo redki neželeni učinki, ki se lahko pokažejo v preiskavah krvi, so: • nesposobnost kostnega mozga proizvajati nove rdeče krvne celice (čista eritrocitna aplazija celic).
English: If overdose occurs, the patient should be treated supportively with appropriate monitoring, as necessary.
Slovenian: V primeru prevelikega odmerjanja je treba bolnike zdraviti s podporno terapijo in jih po potrebi ustrezno spremljati.
English: In rare cases, as the immune system becomes stronger, it can also attack healthy body tissue (autoimmune disorders).
Slovenian: V redkih primerih, ko se imunski sistem okrepi, lahko ta napade tudi zdrava telesna tkiva (avtoimune bolezni).
English: Nucleoside and nucleotide analogues may impact mitochondrial function to a variable degree, which is most pronounced with stavudine, didanosine and zidovudine.
Slovenian: Nukleozidni in nukleotidni analogi lahko v različnih stopnjah vplivajo na mitohondrijsko funkcijo, kar je najbolj izrazito pri stavudinu, didanozinu in zidovudinu.
English: Lamivudine monotherapy is generally not considered an adequate treatment for hepatitis B, since the risk for hepatitis B resistance development is high.
Slovenian: Monoterapija z lamivudinom na splošno ne velja za zadostno zdravljenje hepatitisa B, ker je tveganje za razvoj odpornosti hepatitisa B visoko.
English: What Dovato is and what it is used for
Slovenian: Kaj je zdravilo Dovato in za kaj ga uporabljamo
English: Fosamprenavir/ritonavir decreases dolutegravir concentrations, but based on limited data, did not result in decreased efficacy in Phase III studies.
Slovenian: Fosamprenavir/ritonavir znižuje koncentracije dolutegravirja, vendar pa glede na omejene podatke v študijah 3. faze ni zmanjšal njegove učinkovitosti.
English: Because gastrointestinal (GI) intolerance is considered to be due to local active substance administration, mg/kg or mg/m2 metrics are appropriate determinates of safety cover for this toxicity.
Slovenian: Gastrointestinalna (GI) intoleranca velja za posledico lokalne uporabe zdravilne učinkovine, zato sta enoti mg/kg ali mg/m ustrezni determinanti varnostnega kritja za ta toksični učinek.
English: Due to the potential risk of neural tube defects with dolutegravir, Dovato should not be used during the first trimester unless there is no alternative.
Slovenian: Zaradi morebitnega tveganja za nastanek okvar nevralne cevi pri dolutegravirju se zdravila Dovato ne sme uporabljati v prvem trimesečju, razen če ni alternative.
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Slovenian: Bolnikom je treba svetovati, naj poiščejo medicinsko pomoč, če se jim pojavijo bolečine v sklepih, togost sklepov ali težave pri gibanju.
English: Medicinal products that induce those enzymes or transporters may decrease dolutegravir plasma concentration and reduce the therapeutic effect of dolutegravir.
Slovenian: Zdravila, ki inducirajo te encime ali prenašalce, lahko znižajo plazemske koncentracije dolutegravirja in zmanjšajo njegov terapevtski učinek.