FrancophonIA/ELRC3.0 huggingface dataset:
English: United Kingdom Ennogen Limited 78 York Street
Danish: Storbritanien Ennogen Limited 78 York Street
English: Str. Aleea Eroilor nr. 28, Vişeu de Sus, Judeţul Maramureş 435700 România
Danish: Str. Aleea Eroilor nr. 28, Vişeu de Sus, Judeţul Maramureş 435700 Romania
English: United Kingdom Actavis UK Limited Whiddon Valley
Danish: Storbritanien Actavis UK Limited Whiddon Valley
English: Slandrova ulica 4
Danish: Ljubljana Slandrova ulica 4
English: United Kingdom Accord Healthcare Ltd Sage House
Danish: Storbritanien Accord Healthcare Ltd Sage House
English: United Kingdom Amdipharm plc Regency House
Danish: Storbritanien Amdipharm plc Regency House
English: United Kingdom Crescent Pharma Limited Units 3 & 4
Danish: Storbritanien Crescent Pharma Limited Units 3 & 4
English: Alexandriei, nr 145 A B07-Bragadiru, jud Ilfov România
Danish: Alexandriei, nr 145 A B07-Bragadiru, jud Ilfov Romania
English: 1526 Ljubljana
Danish: 1526 Ljubljana Slovenia
English: 1000 Ljubljana
Danish: 1000 Ljubljana Slovenia
English: Effervescent granules Oral use
Danish: Effervescent granules Oral anvendelse
English: 82102 Bratislava
Danish: 82102 Bratislava Slovakia
English: United Kingdom Pharmvit Limited 177 Bilton Road, Perivale Middlesex UB6 7HQ United Kingdom
Danish: Storbritanien Pharmvit Limited 177 Bilton Road, Perivale Middlesex UB6 7HQ United Kingdom
English: ARENA GROUP S.A Str. Stefan Mihaileanu, nr.31 sector 2; Bucuresti 024022 România
Danish: ARENA GROUP S.A Str. Stefan Mihaileanu, nr.31 sector 2; Bucuresti 024022 Romania
English: Culliganlaan 1 C 1831 Diegem Belgium
Danish: Culliganlaan 1 C 1831 Diegem
English: Laboratório MedinfarProdutos Farmacêuticos, S.A. l Ribeiro de Pavia, 1 - 1ºVenda Nova 2700-547 Amadora Portugal
Danish: Laboratório MedinfarProdutos Farmacêuticos, S.A. l Ribeiro de Pavia, 1 - 1ºVenda Nova 2700-547 Amadora
English: United Kingdom Generics (United Kingdom) Limited
Danish: Storbritanien Generics (United Kingdom Limited
English: United Kingdom Mercury Pharma International Limited 4045 Kingswood Raod City West Business Park County Dublin
Danish: Storbritanien Mercury Pharma International Limited 4045 Kingswood Raod City West Business Park County Dublin
English: S.C. TERAPIA S.A. Str. Fabricii nr. 124 Cluj - Napoca 400632 România
Danish: S.C. TERAPIA S.A. Str. Fabricii nr. 124 Cluj - Napoca 400632 Romania
English: Wasastrasse 50
Danish: KG Wasastrasse 50
English: Sirton Medicare spa Piazza XX Settembre, 2 22079 Villa GuardiaCOMO
Danish: Sirton Medicare spa Piazza XX Settembre, 2 22079 Villa Guardia - COMO Italy
English: Accord Healthcare B.V. De Waterman 15 A 4891 TL Rijsbergen The Netherlands
Danish: De Waterman 15 A 4891 TL Rijsbergen The Netherlands
English: Oral solution
Danish: Oral opløsning
English: Radlická 3185/1c
Danish: Radlická 3185/1c 150 00 Prague Czech Republic
English: Capsule, soft
Danish: Kapsel, blød
English: Polhampton Lane, Overton Hampshire RG25 3ED
Danish: Quidhampton Business Units Polhampton Lane, Overton Hampshire RG25 3ED
English: PROKINYL L.P. 15 mg, gélule à libération prolongée
Danish: 15 mg, gélule à libération prolongée
English: Oral solution betapharm Arzneimittel GmbH
Danish: Oral opløsning betapharm Arzneimittel GmbH
English: Slovak Republic TEVA Pharmaceuticals Slovakia s.r.o.
Danish: TEVA Pharmaceuticals Slovakia s.r.o.
English: Sanofi-aventis Denmark A/S
Danish: Sanofi-aventis Denmark A/S Slotsmarken 13
English: Czech Republic Teva Pharmaceuticals CR, s.r.o.
Danish: Teva Pharmaceuticals CR, s.r.o.
English: Concentrate for solution for infusion
Danish: Koncentrat til infusion, opløsning
English: United Kingdom Rosemont Pharmaceuticals Limited
Danish: Storbritanien Rosemont Pharmaceuticals Limited
English: United Kingdom Metwest Pharmaceuticals Limited
Danish: Storbritanien Metwest Pharmaceuticals Limited
English: Modified-release capsules, hard
Danish: Kapsler med modificeret udløsning, hård
English: United Kingdom Hameln Pharmaceuticals Limited
Danish: Storbritanien Hameln Pharmaceuticals Limited
English: Modified-release capsule, soft
Danish: Kapsel med modificeret udløsning, blød
English: Oral drops
Danish: Orale dråber
English: Medochemie Limited 1-10 Constantinoupleos Str
Danish: Medochemie Limited 1-10 Constantinoupleos Str 3011 Limassol Cyprus
English: 1 - 1 - Venda Nova 2700-547 Amadora Portugal
Danish: Rua Manuel Ribeiro de Pavia 1 - 1 - Venda Nova 2700-547 Amadora Portugal
English: Limassol Industrial Estate Aharnon Street P.O.
Danish: Limassol Industrial Estate Aharnon Street P.O. Box 51706
English: 01445 Radebeul
Danish: 01445 Radebeul Germany
English: AWD.pharma GmbH&Co.KG Wasastrasse 50 Radebeul
Danish: AWD.pharma GmbH&Co.KG Wasastrasse 50
English: Rectal use
Danish: Rektal anvendelse
English: Metoclopramide Hydrochloride 5mg/5ml Oral Solution
Danish: Metoclopramide Hydrochloride 5mg/5ml Oral opløsning
English: Slovak Republic Sandoz Pharmaceuticals d.d.
Danish: Sandoz Pharmaceuticals d.d.
English: Nasal spray, solution Nasal use
Danish: Næsespray, opløsning Nasal anvendelse
English: Suppository
Danish: Suppositorium
English: Nexus, Gloucester
Danish: Nexus, Gloucester Business Park
English: Oral drops, solution
Danish: Orale dråber, opløsning Oral anvendelse
English: Teva Pharma B.V. Computerweg 10
Danish: Teva Pharma B.V.
English: Metoclopramidemonohydrochlor ide Accord 10 mg Tabletten
Danish: Metoclopramidemonohydrochl oride Accord 10 mg Tabletten
English: Solution for injection Intravenous use
Danish: Intramuskulær anvendelse
English: Elitan Injection, 10mg/2ml, Solution for Injection
Danish: Elitan Injection, 10mg/2ml, Injektionsvæske, opløsning
English: Paspertin 50mg/10ml Ampullen 50mg/10ml
Danish: Paspertin 50mg/10ml Ampullen
English: Boumpoulinas 11, 3rd Floor
Danish: Storbritanien Chelonia Healthcare Limited Boumpoulinas 11, 3rd Floor Nicosia, CY-1060
English: 83607 Holzkirchen Germany
Danish: Industriestrasse 25 83607 Holzkirchen Germany
English: METOCLOPRAMID 10 mg
Danish: METOCLOPRAMID 10 mg 10mg
English: Oral solution ratiopharm GmbH Graf-Arco-Str. 3 D-89079 Ulm Germany
Danish: Oral opløsning ratiopharm GmbH Graf-Arco-Str. 3 D-89079 Ulm Germany
English: Rectal use ratiopharm GmbH Graf-Arco-Str. 3 D-89079 Ulm Germany
Danish: Rektal anvendelse ratiopharm GmbH Graf-Arco-Str. 3 D-89079 Ulm Germany
English: MCP-CT 4mg/1ml Tropfen
Danish: MCP-CT 4mg/1ml Tropfen 5.2mg/ml
English: Prolonged-release capsule ratiopharm GmbH Graf-Arco-Str. 3 D-89079 Ulm Germany
Danish: Depotkapsel ratiopharm GmbH Graf-Arco-Str. 3 D-89079 Ulm Germany
English: METOCLOPRAMID LAROPHARM 10mg
Danish: METOCLOPRAMID LAROPHARM
English: Prolonged-release capsule, hard
Danish: Depotkapsel, hård
English: MCP Heumann 10mg Tabletten 10.53mg
Danish: MCP Heumann 10mg Tabletten
English: Maxolon Paediatric Liquid
Danish: Maxolon Paediatric Liquid 5mg/5ml
English: Sector 3, Bucureşti
Danish: Sector 3, Bucureşti 032266 Romania
English: Long-term exposure (at least 48 weeks)
Danish: Langvarig eksponering (mindst 48 uger)
English: You and your doctor should check your weight regularly.
Danish: Du og din læge bør jævnligt kontrollere din vægt.
English: Try to take your tablets at the same time each day.
Danish: Forsøg at tage tabletterne på samme tidspunkt hver dag.
English: There are no adequate and well-controlled studies in pregnant women.
Danish: Der foreligger ikke tilstrækkelige og velkontrollerede studier af gravide kvinder.
English: Patients should be closely monitored during this period.
Danish: Patienterne bør følges nøje i denne periode.
English: Increased appetite
Danish: Øget appetit
English: Information on long term safety is primarily limited to open-label, uncontrolled data.
Danish: Information om sikkerheden ved langvarig brug er primært begrænset til open-label, ikke kontrollerede data.
English: This will usually pass on its own but if it does not, tell your doctor.
Danish: Det vil sædvanligvis gå over af sig selv, men hvis det ikke gør, så fortæl det til lægen.
English: Growth parameters were decreased at high doses.
Danish: Vækstparametre mindskedes ved høje doser.
English: It is recommended that blood pressure is measured periodically in patients over 65 years.
Danish: Det anbefales at måle blodtrykket periodisk på patienter over 65 år.
English: Tolerance developed to the CNS depression.
Danish: Der udvikledes tolerance over for CNS depressionen.
English: Consequently, newborns should be monitored carefully.
Danish: Derfor bør nyfødte omhyggeligt monitoreres.
English: Close medical supervision and monitoring should continue until the patient recovers.
Danish: Omhyggelig medicinsk kontrol og overvågning bør fortsætte indtil patienten kommer sig.
English: These symptoms can temporally deteriorate or even arise after discontinuation of treatment.
Danish: Disse symptomer kan temporært forværres eller endog opstå efter afslutning af behandling.
English: Some fatal cases have been reported in this particular group of patients.
Danish: Der er set nogle dødsfald i denne gruppe af patienter.
English: Tell your doctor.
Danish: Fortæl det til din læge.
English: A lower starting dose (5 mg) should be considered for such patients.
Danish: En lavere startdosis (5 mg) bør overvejes til sådanne patienter.
English: Speech disorder was also reported commonly.
Danish: Taleforstyrrelser blev ligeledes rapporteret almindeligt.
English: Signs and symptoms
Danish: Tegn og symptomer
English: People with this disease may also feel depressed, anxious or tense.
Danish: Mennesker med denne lidelse kan også føle sig deprimerede, angste eller anspændte.
English: Such factors possibly contribute to the higher average exposure observed in adolescents.
Danish: Sådanne faktorer medvirker muligvis til den højere gennemsnitlige eksponering, som blev set hos unge.
English: In some cases, a prior increase in body weight has been reported which may be a predisposing factor.
Danish: I nogle tilfælde er en forudgående vægtøgning rapporteret, hvilket kan være en disponerende faktor.
English: In a study of Caucasians, Japanese, and Chinese subjects, there were no differences in the pharmacokinetic parameters among the three populations.
Danish: I et studie af kaukasiske, japanske og kinesiske individer fandtes ingen forskel i farmakokinetiske parametre i de tre populationsgrupper.
English: Demographic differences between the adolescents and adults include a lower average body weight and fewer adolescents were smokers.
Danish: Demografiske forskelle mellem unge og voksne omfatter en lavere gennemsnitlig legemsvægt og færre unge var rygere.
English: If you suffer from any of the following illnesses tell your doctor as soon as possible:
Danish: Hvis du lider af en af de følgende sygdomme, skal du fortælle det til din læge hurtigst muligt:
English: Increased total bilirubin
Danish: Forhøjet totalbilirubin
English: • Medicines of this type may cause unusual movements mainly of the face or tongue.
Danish: • Denne type medicin kan forårsage usædvanlige bevægelser af især ansigt eller tunge.
English: The mean increase in olanzapine AUC was 52 % and 108 % respectively.
Danish: Den gennemsnitlige øgning af olanzapin AUC var henholdsvis 52 % og 108 %.
English: Cardiovascular monitoring is necessary to detect possible arrhythmias.
Danish: Det er nødvendigt at overvåge det kardiovaskulære system for at afsløre mulige arytmier.
English: Absolute oral bioavailability relative to intravenous administration has not been determined.
Danish: Fuldstændig peroral biotilgængelighed relativ til intravenøs administration er ikke bestemt.
English: Your doctor may suggest you to reduce the dose gradually before stopping treatment.
Danish: Din læge vil måske foreslå dig, at du nedsætter din dosis gradvist, før du helt stopper.
English: Hyperglycaemia and diabetes
Danish: Hyperglykæmi og diabetes
English: NMS is a potentially life-threatening condition associated with antipsychotic medicinal products.
Danish: NMS er en potentielt livstruende tilstand, som er forbundet med antipsykotika.
English: The major circulating metabolite is the 10-N-glucuronide, which does not pass the blood brain barrier.
Danish: Den overvejende cirkulerende metabolit er 10-N-glucuronid, som ikke passerer blod-hjerne barrieren.
English: The absorption is not affected by food.
Danish: Absorptionen påvirkes ikke af fødeindtagelse.
English: However, olanzapine (5-20 mg) demonstrated a comparable safety profile in female (n=467) as in male patients (n=869).
Danish: Olanzapin (5-20 mg) udviste imidlertid en sammenlignelig sikkerhedsprofil hos kvindelige (n=467) som hos mandlige patienter (n=869).
English: Although no clinical studies designed to compare adolescents to adults have been conducted, data from the adolescent trials were compared to those of the adult trials.
Danish: På trods af, at ingen kliniske studier designet til at sammenligne unge med voksne er blevet udført, er data fra studier med unge blevet sammenlignet med dem fra voksenstudier.
English: Contact your doctor or hospital straight away if you experience any of the above symptoms.
Danish: Kontakt omgående din læge eller dit sygehus, hvis du får nogen af de ovennævnte symptomer.
English: Tardive Dyskinesia
Danish: Tardiv dyskinesi
English: Discontinuation of treatment
Danish: Ophør med behandling
English: However, the marketing authorisation holder shall submit periodic safety update reports for this medicinal product if the product is included in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal.
Danish: Indehaveren af markedsføringstilladelsen skal imidlertid fremsende PSUR'er, såfremt lægemidlet bliver inkluderet på listen over EU-referencedatoer (EURD list), som fastsat i artikel 107c, stk. 7, i direktiv 2001/83/EF og offentliggjort på den europæiske webportal for lægemidler.
English: If this happens do not drive or operate any tools or machines.
Danish: Hvis dette opstår, må du ikke føre bil eller betjene værktøj eller maskiner.
English: Dogs tolerated single oral doses up to 100 mg/kg without mortality.
Danish: Hunde tolererede perorale enkeltdoser på op til 100 mg/kg uden mortalitet.
English: Additional information on special populations
Danish: Yderligere oplysninger om særlige populationer
English: Nevertheless, because human experience is limited, olanzapine should be used in pregnancy only if the potential benefit justifies the potential risk to the foetus.
Danish: Da human erfaring er begrænset, bør olanzapin kun anvendes til gravide, hvis den potentielle gavnlige effekt retfærdiggør den potentielle risiko for fosteret.
English: Olanzapine can be given without regards for meals as absorption is not affected by food.
Danish: Olanzapin kan tages uden hensyntagen til måltider, da absorptionen ikke påvirkes af fødeindtagelse.
English: Decreased libido in males and females
Danish: Nedsat libido hos mænd og kvinder
English: Date of latest renewal: 22 May 2013
Danish: Dato for første markedsføringstilladelse: 7. oktober 2008 Dato for seneste fornyelse: 22. maj 2013
English: • Tell the doctor if you or someone else in your family has a history of blood clots, as medicines like these have been associated with the formation of blood clots.
Danish: Fortæl det til lægen, hvis du eller nogen i din familie tidligere har haft blodpropper, da denne type medicin kan være forbundet med dannelse af blodpropper.
English: For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
Danish: Hvis du ønsker yderligere oplysninger om dette lægemiddel skal du henvende dig til den lokale repræsentant for indehaveren af markedsføringstilladelsen:
English: Only slight to moderate increase in olanzapine clearance has been observed.
Danish: Der er kun observeret en let til moderat øgning af olanzapin clearance.
English: Potential interactions affecting olanzapine
Danish: Interaktioner, der potentielt kan påvirke olanzapin
English: Tell your doctor immediately if you have:
Danish: Fortæl straks lægen, hvis du får:
English: 16 Elevated plasma prolactin levels were reported in 47.4 % of adolescent patients.
Danish: 16 Forhøjet plasma-prolaktin blev rapporteret hos 47,4 % af de unge patienter.
English: As a routine precaution, if you are over 65 years your blood pressure may be monitored by your doctor.
Danish: Som almindelig forholdsregel bør du - hvis du er over 65 år - have målt dit blodtryk hos din læge.
English: The mean increase in olanzapine Cmax following fluvoxamine was 54 % in female nonsmokers and 77 % in male smokers.
Danish: Den gennemsnitlige øgning af olanzapin Cmax efter fluvoxamin var 54 % hos kvindelige ikke-rygere og 77 % hos mandlige rygere.
English: Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during treatment with olanzapine.
Danish: Patienter bør rådes til at informere deres læge, hvis de bliver gravide eller påtænker at blive gravide under behandling med olanzapin.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Danish: Hvis du er gravid eller ammer, har mistanke om, at du er gravid, eller planlægger at blive gravid, skal du spørge din læge eller apotekspersonalet til råds, før du bruger dette lægemiddel.
English: Gerard Laboratories, 35/36 Baldoyle Industrial Estate, Grange Road, Dublin 13, Ireland Generics [UK] Limited, Station Close, Potters Bar, Hertfordshire, EN6 1TL, United Kingdom.
Danish: Gerard Laboratories, 35/36 Baldoyle Industrial Estate, Grange Road, Dublin 13, Irland og Generics [UK] Limited, Station Close, Potters Bar, Hertfordshire, EN6 1TL, Storbritannien
English: The starting dose and dose range need not be routinely altered for non-smokers relative to smokers.
Danish: Det er ikke nødvendigt rutinemæssigt at ændre startdosis og dosisinterval hos ikke-rygere i forhold til rygere.
English: Adolescents (ages 13 to 17 years): The pharmacokinetics of olanzapine are similar between adolescents and adults.
Danish: Unge (alder 13 - 17 år): Farmakokinetikken af olanzapin er den samme hos unge og voksne.
English: The median lethal doses were approximately 210 mg/kg (mice) and 175 mg/kg (rats).
Danish: De mediane letal-doser var ca. 210 mg/kg (mus) og 175 mg/kg (rotter).
English: Olanzapine is well absorbed after oral administration, reaching peak plasma concentrations within 5 to 8 hours.
Danish: Olanzapin absorberes godt efter oral administration og når maksimal plasmakoncentration indenfor 5 til 8 timer.
English: When more than one factor is present which might result in slower metabolism (female gender, geriatric age, non-smoking status), consideration should be given to decreasing the starting dose.
Danish: Når mere end én parameter, som kan føre til nedsat metabolisering, er til stede (kvinder, ældre, ikkerygere), bør det overvejes at reducere startdosis.
English: No studies on the effects on the ability to drive and use machines have been performed.
Danish: Der er ikke foretaget studier af virkninger på evnen til at føre motorkøretøj eller betjene maskiner.
English: Unlike some other antipsychotic agents, olanzapine increases responding in an “anxiolytic” test.
Danish: I modsætning til visse andre antipsykotika øger olanzapin responset ved en "anxiolytisk" test.
English: There is no specific antidote for olanzapine.
Danish: Der er ingen specifik antidot til olanzapin.
English: • Moderate to severe manic episodes, a condition with symptoms of excitement or euphoria.
Danish: • Moderate til svære maniske episoder, en tilstand med symptomer som begejstring og eufori.
English: Olanzapine had no teratogenic effects.
Danish: Olanzapin udviste ingen teratogene virkninger.
English: Decreased bioavailability
Danish: Nedsat biotilgængelighed
English: Activated charcoal reduces the bioavailability of oral olanzapine by 50 % to 60 % and should be taken at least 2 hours before or after olanzapine.
Danish: Aktivt kul reducerer biotilgængeligheden af oral olanzapin med 50 til 60 % og bør tages mindst 2 timer før eller efter olanzapin.
English: In particular, tell your doctor if you are taking:
Danish: Det er især vigtigt at fortælle lægen, hvis du tager:
English: Show the doctor your pack of tablets.
Danish: Vis tabletpakningen til lægen.
English: The efficacy of olanzapine was not established in these trials.
Danish: Effekten af olanzapin blev ikke påvist i disse forsøg.
English: Possible side effects Like all medicines, this medicine can cause side effects, although not everybody gets them.
Danish: Dette lægemiddel kan som al anden medicin give bivirkninger, men ikke alle får bivirkninger.
English: Do not use epinephrine, dopamine, or other sympathomimetic agents with beta agonist activity since beta stimulation may worsen hypotension.
Danish: Brug ikke adrenalin, dopamin eller andre sympatomimetiske midler med betaagonist aktivitet, da beta-stimulation kan forværre hypotension.
English: • if you are allergic (hypersensitive) to olanzapine, peanut or soya or any of the other ingredients of this medicine (listed in section 6).
Danish: • hvis du er allergisk (overfølsom) over for olanzapin, jordnødder, soja eller et af de øvrige indholdsstoffer i dette lægemiddel (angivet i punkt 6).
English: The plasma protein binding of olanzapine was about 93 % over the concentration range of about 7 to about 1000 ng/ml.
Danish: Olanzapins plasmaproteinbinding var ca. 93 % over koncentrationsintervallet fra ca. 7 til ca. 1.000 ng/ml.
English: The higher incidence of death was not associated with olanzapine dose (mean daily dose 4.4 mg) or duration of treatment.
Danish: Den højere forekomst af dødsfald var ikke relateret til olanzapindosis (gennemsnitlig daglig dosis, 4,4 mg) eller behandlingsvarighed.
English: During treatment with olanzapine, adolescents gained significantly more weight compared with adults.
Danish: Under behandling med olanzapin tog de unge signifikant mere på i vægt sammenlignet med voksne.
English: If a patient develops signs and symptoms indicative of NMS, or presents with unexplained high fever without additional clinical manifestations of NMS, all antipsychotic medicines, including olanzapine must be discontinued.
Danish: Hvis en patient får tegn og symptomer, som tyder på NMS, eller får uforklarlig høj feber uden yderligere kliniske manifestationer af NMS, bør alle antipsykotika, inklusive olanzapin, seponeres.
English: Clinically significant weight gain (≥ 7 %) appears to occur more frequently in the adolescent population compared to adults with comparable exposures.
Danish: Klinisk signifikant vægtøgning (≥ 7 %) synes at forekomme hyppigst i den unge population sammenlignet med ældre med sammenlignelig eksponering.
English: Clinically significant weight gain was observed across all baseline Body Mass Index (BMI) categories.
Danish: 1Klinisk signifikant vægtøgning blev observeret på tværs af alle baseline bodymassindex (BMI) kategorier.
English: In cases of moderate hepatic insufficiency (cirrhosis, Child-Pugh Class A or B), the starting dose should be 5 mg and only increased with caution.
Danish: I tilfælde af moderat leverinsufficiens (cirrose, Child-Pugh klasse A eller B) bør startdosis være 5 mg og bør kun øges med forsigtighed.
English: In studies up to 3 months duration in mice and up to 1 year in rats and dogs, the predominant effects were CNS depression, anticholinergic effects, and peripheral haematological disorders.
Danish: I studier af op til 3 måneders varighed af mus og op til 1 års varighed af rotter og hunde var CNS depression, antikolinerge effekter og perifere hæmatologiske forstyrrelser de dominerende effekter.
English: The magnitude of weight gain and the proportion of adolescent patients who had clinically significant weight gain were greater with long-term exposure (at least 24 weeks) than with short-term exposure.
Danish: Størrelsen af vægtøgning og andelen af unge patienter, som havde klinisk signifikant vægtøgning, var større ved langvarig eksponering (mindst 24 uger) end ved kortvarig eksponering.