FrancophonIA/ELRC3.0 huggingface dataset:
English: There is no experience with doses above 800 mg in clinical studies.
Slovenian: Izkušenj z odmerki, večjimi od 800 mg, iz kliničnih študij ni.
English: Opaque blisters (PVC/PE/PVDC and aluminum).
Slovenian: Neprozorni pretisni omoti (PVC/PE/PVDC in aluminij).
English: If you encounter blistering of the skin it may be a sign for a condition called bullous pemphigoid.
Slovenian: Če opazite mehurje na koži, je to morda znak stanja, ki se imenuje bulozni pemfigoid.
English: • Severe and persistent pain in the abdomen (stomach area) which might reach through to your back with or without nausea and vomiting, as these could be signs of an inflamed pancreas
Slovenian: • hudo in dolgotrajno bolečino v abdomnu (predelu trebuha), ki se lahko širi tudi v hrbet, s sočasno slabostjo in bruhanjem ali brez tega, saj ti znaki lahko kažejo na vnetje trebušne slinavke (pankreatitis).
English: If you take more Ristaben than you should If you take more than the prescribed dosage of this medicine, contact your doctor immediately.
Slovenian: Če ste vzeli večji odmerek zdravila Ristaben, kot bi smeli Če ste vzeli večji odmerek tega zdravila od predpisanega, se takoj posvetujte z zdravnikom.
English: Tell your doctor if you have or have had: - a disease of the pancreas (such as pancreatitis) - gallstones, alcohol dependence or very high levels of triglycerides (a form of fat) in your blood.
Slovenian: Obvestite zdravnika, če imate ali ste kdaj imeli: - bolezen trebušne slinavke (kot je pankreatitis) - žolčne kamne ali zelo visoko vrednost trigliceridov (oblika maščob) v krvi ali če ste ali ste bili odvisni od alkohola.
English: Study
Slovenian: Študija
English: See TECOS Cardiovascular Safety Study below.
Slovenian: Glejte Študija srčno-žilne varnosti TECOS spodaj.
English: If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule.
Slovenian: Če se spomnite šele, ko je že čas, da vzamete naslednji odmerek, pozabljeni odmerek izpustite in nadaljujte z jemanjem zdravila ob predpisanem času.
English: Incidence rate per patientyears* N (%)
Slovenian: Pojavnost na 100 bolnik-let* N (%)
English: Elderly subjects (65 to 80 years) had approximately 19 % higher plasma concentrations of sitagliptin compared to younger subjects.
Slovenian: Pri starejših bolnikih (65 do 80 let) so bile plazemske koncentracije sitagliptina približno za 19 % večje kot pri mlajših osebah.
English: Due to lack of human data, Ristaben should not be used during pregnancy.
Slovenian: Zaradi pomanjkanja podatkov pri ljudeh se zdravila Ristaben med nosečnostjo ne sme jemati.
English: Animal data do not suggest an effect of treatment with sitagliptin on male and female fertility.
Slovenian: Podatki za živali ne kažejo na vpliv zdravljenja s sitagliptinom na plodnost samcev in samic.
English: Sitagliptin is not a substrate for OCT2 or OAT1 or PEPT1/2 transporters.
Slovenian: Sitagliptin ni substrat za prenašalce OCT2 ali OAT1 ali PEPT1/2.
English: Further, GLP-1 does not impair the normal glucagon response to hypoglycaemia.
Slovenian: Poleg tega GLP-1 ne zmanjša normalnega odziva glukagona na hipoglikemijo.
English: Your doctor may reduce the dose of your sulphonylurea or insulin medicine.
Slovenian: Zdravnik vam bo morda zmanjšal odmerek sulfonilsečnine ali insulina.
English: Your doctor has prescribed this medicine to help lower your blood sugar, which is too high because of your type 2 diabetes.
Slovenian: Zdravnik vam je to zdravilo predpisal, da vam bo pomagalo pri zniževanju krvnega sladkorja, ki je previsok zaradi sladkorne bolezni tipa 2.
English: The dose is 100 mg sitagliptin once daily.
Slovenian: Odmerek je 100 mg sitagliptina enkrat na dan.
English: This medicine helps to increase the levels of insulin produced after a meal and decreases the amount of sugar made by the body.
Slovenian: To zdravilo pomaga povečati količino insulina, ki nastane po obroku, in zmanjšuje nastajanje sladkorja v telesu.
English: Because of the high safety margin (19-fold at this no-effect level), these neoplastic changes are not considered relevant for the situation in humans.
Slovenian: Zaradi visoke meje varnosti (19-kratna izpostavljenost brez škodljivega učinka) teh neoplastičnih sprememb nimamo za pomembne za klinično uporabo pri človeku.
English: For all other endpoints, the p-values correspond to a test of differences in hazard rates.
Slovenian: Za vse druge opazovane dogodke ustrezajo vrednosti p testiranjem razlik razmerij ogroženosti.
English: (see section 4.2 and 5.2).
Slovenian: (glejte poglavje 4).
English: Resolution of pancreatitis has been observed after discontinuation of sitagliptin (with or without supportive treatment), but very rare cases of necrotising or haemorrhagic pancreatitis and/or death have been reported.
Slovenian: Opazili so, da je po prenehanju jemanja sitagliptina pankreatitis izginil (z ali brez podpornega zdravljenja), v zelo redkih primerih pa so poročali o nekrotizirajočem ali hemoragičnem pankreatitisu in/ali smrti.
English: Patients should be informed of the characteristic symptom of acute pancreatitis: persistent, severe abdominal pain.
Slovenian: Bolnike je treba seznaniti z značilnim simptomom akutnega pankreatitisa, to je z dolgotrajno hudo bolečino v trebuhu.
English: Packs of 14, 28, 30, 56, 84, 90 or 98 film-coated tablets and 50 x 1 film-coated tablets in perforated unit dose blisters.
Slovenian: Pakiranja po 14, 28, 30, 56, 84, 90 ali 98 filmsko obloženih tablet in 50 x 1 filmsko obložena tableta v perforiranih pretisnih omotih za enkratni odmerek.
English: These reactions include anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome.
Slovenian: Te reakcije vključujejo anafilaksijo, angioedem in eksfoliativna stanja na koži, vključno s Stevens-Johnsonovim sindromom.
English: TECOS Cardiovascular Safety Study
Slovenian: Študija srčno-žilne varnosti TECOS
English: Adverse reactions are listed below (Table 1) by system organ class and frequency.
Slovenian: Neželeni učinki so v nadaljevanju (preglednica 1) razvrščeni po organskih sistemih in pogostnosti.
English: If you forget to take Ristaben
Slovenian: Če ste pozabili vzeti zdravilo Ristaben
English: What Ristaben is and what it is used for What you need to know before you take Ristaben How to take Ristaben
Slovenian: Kaj je zdravilo Ristaben in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Ristaben Kako jemati zdravilo Ristaben Možni neželeni učinki
English: Other medicines and Ristaben
Slovenian: Druga zdravila in zdravilo Ristaben
English: It is not known if this medicine is safe and effective when used in children and adolescents under 18 years of age.
Slovenian: Ni znano, če je uporaba tega zdravila pri otrocih in mladostnikih do 18. leta starosti varna in učinkovita.
English: The difference was mainly due to a higher percentage of patients in the placebo group experiencing 3 or more episodes of hypoglycaemia (9.4 vs. 19.1 %).
Slovenian: Razlika je bila v glavnem zaradi večjega odstotka bolnikov, ki so doživeli 3 ali več epizod hipoglikemije v skupini, ki je prejemala placebo (9,4 proti 19,1 %).
English: Improvement of surrogate markers of beta cell function, including HOMA-β (Homeostasis Model Assessment-β), proinsulin to insulin ratio, and measures of beta cell responsiveness from the frequently-sampled meal tolerance test were observed.
Slovenian: Opazili so izboljšanje surogatnih markerjev funkcije beta celic, vključno s HOMA-β (Homeostasis Model Assessment-β), razmerjem proinsulin/insulin in meritvami funkcije beta celic pri tolerančnem testu s hrano (s pogostim vzorčenjem).
English: If you miss a dose, take it as soon as you remember.
Slovenian: Pozabljeni odmerek vzemite takoj, ko se spomnite.
English: These changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful.
Slovenian: Te spremembe farmakokinetike sitagliptina niso smatrali za klinično pomembne.
English: If you have a serious allergic reaction (frequency not known), including rash, hives, blisters on the skin/peeling skin and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing, stop taking this medicine and call your doctor right away.
Slovenian: V primeru hude alergijske reakcije (pogostnost neznana), ki vključuje izpuščaj, koprivnico, mehurje na koži/luščenje kože in otekanje obraza, ustnic, jezika ter žrela, kar lahko povzroči težave pri dihanju ali požiranju, prenehajte jemati to zdravilo in takoj pokličite zdravnika.
English: Sitagliptin is a potent and highly selective inhibitor of the enzyme DPP-4 and does not inhibit the closely-related enzymes DPP-8 or DPP-9 at therapeutic concentrations.
Slovenian: Sitagliptin je močan in močno selektiven zaviralec encima DPP-4 in v terapevtskih koncentracijah ne zavira zelo sorodnih encimov DPP-8 ali DPP-9.
English: Very common (may affect more than 1 in 10 people): low blood sugar Common: constipation
Slovenian: Zelo pogosti (lahko se pojavijo pri več kot 1 od 10 ljudi): nizek krvni sladkor
English: Serious adverse reactions including pancreatitis and hypersensitivity reactions have been reported.
Slovenian: Poročali so o resnih neželenih učinkih, vključno s pankreatitisom in preobčutljivostnimi reakcijami.
English: Dose-proportionality was not established for Cmax and C24hr (Cmax increased in a greater than dose-proportional manner and C24hr increased in a less than dose-proportional manner).
Slovenian: Za vrednosti Cmax in C24ur niso ugotovili sorazmernega povečanja z odmerkom (vrednost Cmax se je povečevala bolj kot sorazmerno, vrednost C24ur pa se je povečevala manj kot sorazmerno).
English: This study involved 423 patients with chronic renal impairment (estimated glomerular filtration rate < 50 ml/min).
Slovenian: Študija je vključevala 423 bolnikov s kronično ledvično okvaro (ocenjena hitrost glomerulne filtracije < 50 ml/min).
English: Cardiovascular death
Slovenian: Srčno-žilna smrt
English: When considering the use of sitagliptin in combination with another anti-diabetic medicinal product, its conditions for use in patients with renal impairment should be checked.
Slovenian: Pri presoji glede uporabe sitagliptina v kombinaciji z drugim antidiabetikom je treba preveriti pogoje za uporabo tega zdravila pri bolnikih z ledvično okvaro.
English: Sitagliptin is secreted in considerable amounts into the milk of lactating rats (milk/plasma ratio: 4:1).
Slovenian: Pri doječih podganah se je sitagliptin v znatnih količinah izločal v mleko (razmerje mleko/plazma 4:1).
English: Do not use this medicine after the expiry date which is stated on the blister and the carton after 'EXP'.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu in škatli za oznako "EXP".
English: Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin.
Slovenian: Sitagliptin je substrat za humani organski anionski prenašalec-3 (hOAT-3 - human organic anion transporter-3), ki bi lahko bil vključen v izločanje sitagliptina skozi ledvice.
English: Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion.
Slovenian: Izločanje sitagliptina poteka primarno preko ledvične sekrecije in vključuje aktivno tubularno sekrecijo.
English: In vitro data showed that sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4 and CYP1A2.
Slovenian: In vitro pridobljeni podatki kažejo, da sitagliptin ni zaviralec izoencimov CYP CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 ali 2B6 in ni induktor CYP3A4 ter CYP1A2.
English: Combination Therapy Studies
Slovenian: Študije kombiniranega zdravljenja
English: In a two-day study in healthy subjects, sitagliptin alone increased active GLP-1 concentrations, whereas metformin alone increased active and total GLP-1 concentrations to similar extents.
Slovenian: V dvodnevni študiji pri zdravih osebah je sitagliptin sam povečal koncentracijo aktivnega GLP-1, pri čemer je tudi sam metformin v podobnem obsegu povečal koncentracijo aktivnega in celokupnega GLP-1.
English: Hypoglycaemia has been reported in combination with sulphonylurea (4.7 %-13.8 %) and insulin (9.6 %) (see section 4.4).
Slovenian: O hipoglikemiji so poročali pri kombinaciji s sulfonilsečnino (4,7 % - 13,8 %) in z insulinom (9,6 %) (glejte poglavje 4.4).
English: Two studies were conducted to evaluate the efficacy and safety of sitagliptin monotherapy.
Slovenian: Izvedeni sta bili dve študiji, ki sta ovrednotili učinkovitost in varnost sitagliptina kot samostojnega zdravila.
English: These included hypoglycaemia (frequency very common with the combination of sulphonylurea and metformin), influenza (common with insulin (with or without metformin)), nausea and vomiting (common with metformin), flatulence (common with metformin or pioglitazone), constipation (common with the combination of sulphonylurea and metformin), peripheral oedema (common with pioglitazone or the combination of pioglitazone and metformin), somnolence and diarrhoea (uncommon with metformin), and dry mouth (uncommon with insulin (with or without metformin)).
Slovenian: Ti so vključevali hipoglikemijo (pogostnost - zelo pogosta v kombinaciji s sulfonilsečnino in metforminom), gripo (pogostnost - pogosta z insulinom (z ali brez metformina)), navzeo in bruhanje (pogostnost - pogosta z metforminom), flatulenco (pogostnost - pogosta z metforminom ali pioglitazonom), zaprtje (pogostnost - pogosta v kombinaciji s sulfonilsečnino in metforminom), periferni edem (pogostnost - pogosta s pioglitazonom ali v kombinaciji s pioglitazonom in metforminom), zaspanost in diarejo (pogostnost - občasna z metforminom) in suha usta (pogostnostobčasna z insulinom (z ali brez metformina)).
English: The effect of potent CYP3A4 inhibitors in the setting of renal impairment has not been assessed in a clinical study.
Slovenian: Učinkov močnih zaviralcev CYP3A4 pri ledvični okvari v klinični študiji niso ovrednotili.
English: The renal clearance of sitagliptin was not meaningfully altered.
Slovenian: Ledvični očistek sitagliptina se ni pomembno spremenil.
English: In this study, the proinsulin to insulin ratio, a marker of efficiency of insulin synthesis and release, improved with sitagliptin and deteriorated with glipizide treatment.
Slovenian: V tej študiji se je razmerje proinsulin/insulin, ki je označevalec učinkovitosti sinteze in sproščanja insulina, pri zdravljenju s sitagliptinom izboljšalo, pri zdravljenju z glipizidom pa poslabšalo.
English: Hazard Ratio (95% CI)
Slovenian: Razmerje ogroženosti (95 % IZ)
English: The improvement in glycaemic control observed with this medicinal product may be mediated by enhancing the levels of active incretin hormones.
Slovenian: Izboljšanje urejenosti glikemije, ki so ga opazili pri tem zdravilu, je lahko posledica povečanja količine aktivnih inkretinov.
English: No dose adjustment is necessary based on gender, race, or body mass index (BMI).
Slovenian: Na osnovi spola, rase ali indeksa telesne mase (ITM) odmerka ni treba prilagajati.
English: Treatment may be administered without regard to the timing of dialysis.
Slovenian: Zdravilo se lahko zaužije ne glede na čas dialize.
English: Sitagliptin prevents the hydrolysis of incretin hormones by DPP-4, thereby increasing plasma concentrations of the active forms of GLP-1 and GIP.
Slovenian: Sitagliptin preprečuje hidrolizo inkretinov z DPP-4 in tako povečuje plazemske koncentracije aktivnih oblik GLP-1 in GIP.
English: Digoxin: Sitagliptin had a small effect on plasma digoxin concentrations.
Slovenian: Digoksin: Sitagliptin je imel majhen učinek na koncentracijo digoksina v plazmi.
English: When used in combination with metformin and/or a PPAR agonist, the dose of metformin and/or PPAR agonist should be maintained, and Ristaben administered concomitantly.
Slovenian: Pri uporabi v kombinaciji z metforminom in/ali agonistom PPAR je treba odmerek metformina in/ali agonista PPAR ohraniti in zdravilo Ristaben uporabljati sočasno.
English: Taking this medicine in combination with medicines called sulphonylureas or with insulin can cause hypoglycaemia, which may affect your ability to drive and use machines or work without safe foothold.
Slovenian: Jemanje tega zdravila v kombinaciji z zdravili, imenovanimi sulfonilsečnine, ali z insulinom lahko povzroči hipoglikemijo, ki lahko vpliva na sposobnost vožnje in upravljanja strojev ali na delo v nevarnem okolju.
English: It is not known if sitagliptin is dialysable by peritoneal dialysis.
Slovenian: Ni znano, če se sitagliptin odstrani s peritonealno dializo.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Ristaben in one or more subsets of the paediatric population in type 2 diabetes mellitus (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od obveze za predložitev rezultatov študij z zdravilom Ristaben za vse skupine pediatrične populacije za sladkorno bolezen tipa 2 (za podatek o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: C]sitagliptin dose to healthy subjects, approximately 100 % of the administered radioactivity was eliminated in faeces (13 %) or urine (87 %) within one week of dosing.
Slovenian: C]sitagliptina zdravim osebam se je v enem tednu po prejemu odmerka približno 100 % prejete radioaktivnosti izločilo z blatom (13 %) ali urinom (87 %).
English: Overall, sitagliptin improved glycaemic control when used as monotherapy or in combination treatment (see Table 2).
Slovenian: Na splošno je sitagliptin izboljšal urejenost glikemije, če se je uporabljal sam ali v kombinaciji z drugimi zdravili (glejte preglednico 2).
English: In clinical studies, approximately 13.5 % of the dose was removed over a 3- to 4-hour haemodialysis session.
Slovenian: V kliničnih študijah se je med 3- do 4-urno hemodializo odstranilo približno 13,5 % odmerka.
English: In patients with normal renal function, metabolism, including via CYP3A4, plays only a small role in the clearance of sitagliptin.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic ima presnova, vključno s presnovo preko CYP3A4, le majhno vlogo pri očistku sitagliptina.
English: Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should.
Slovenian: Sladkorna bolezen tipa 2 je stanje, pri katerem v telesu ne nastaja dovolj insulina, delovanje nastalega insulina pa ni ustrezno.
English: In another study involving 91 patients with type 2 diabetes and chronic renal impairment (creatinine clearance < 50 ml/min), the safety and tolerability of treatment with sitagliptin at 25 or 50 mg once daily were generally similar to placebo.
Slovenian: V še eni študiji, ki je vključevala 91 bolnikov s sladkorno boleznijo tipa 2 in s kronično ledvično okvaro (kreatininski očistek < 50 ml/min), sta bili varnost in tolerabilnost zdravljenja s sitagliptinom v odmerkih 25 ali 50 mg enkrat na dan na splošno podobni kot pri placebu.
English: It is not known if this medicine passes into breast milk.
Slovenian: Ni znano, če se to zdravilo izloča v materino mleko.
English: Merck Sharp & Dohme Ltd. Shotton Lane, Cramlington Northumberland NE23 3JU United Kingdom
Slovenian: Merck Sharp & Dohme Ltd. Shotton Lane, Cramlington Northumberland NE23 3JU Velika Britanija
English: Sitagliptin is primarily eliminated unchanged in urine, and metabolism is a minor pathway.
Slovenian: Sitagliptin se primarno izloča z urinom v nespremenjeni obliki, presnova pa je manj pomemben način izločanja.
English: Other potential causes for the event should be assessed, and alternative treatment for diabetes initiated.
Slovenian: Oceniti morate tudi ostale možne vzroke za nastali zaplet ter začeti sladkorno bolezen zdraviti z drugimi zdravili.
English: The mean glipizide dose used in the comparator group was 10 mg per day with approximately 40 % of patients requiring a glipizide dose of  5 mg/day throughout the study.
Slovenian: Povprečni odmerek glipizida, ki so ga uporabili v primerjalni skupini, je bil 10 mg na dan, pri čemer je ves čas študije približno 40 % bolnikov potrebovalo odmerek glipizida  5 mg/dan.
English: Because there is a dosage adjustment based upon renal function, assessment of renal function is recommended prior to initiation of Ristaben and periodically thereafter.
Slovenian: Ker prilagoditev odmerka temelji na ledvični funkciji, pred začetkom zdravljenja z zdravilom Ristaben in periodično tekom zdravljenja priporočamo oceno ledvične funkcije.
English: After a median follow up of 3 years, sitagliptin, when added to usual care, did not increase the risk of major adverse cardiovascular events or the risk of hospitalization for heart failure compared to usual care without sitagliptin in patients with type 2 diabetes (Table 3).
Slovenian: Po 3 letih spremljanja (mediana) sitagliptin pri bolnikih s sladkorno boleznijo tipa 2, dodan običajnemu zdravljenju, ni povečal tveganja za pomembne neželene srčno-žilne dogodke ali tveganja za hospitalizacijo zaradi srčnega popuščanja v primerjavi z bolniki, ki so prejemali običajno zdravljenje brez sitagliptina (preglednica 3).
English: In vitro transport studies showed that sitagliptin is a substrate for p-glycoprotein and organic anion transporter-3 (OAT3).
Slovenian: Študije transporta in vitro so pokazale, da je sitagliptin substrat za p-glikoprotein in organski anionski prenašalec-3 (OAT3).
English: C]sitagliptin oral dose, approximately 16 % of the radioactivity was excreted as metabolites of sitagliptin.
Slovenian: C]sitagliptina se je približno 16 % radioaktivnosti izločilo v obliki presnovkov sitagliptina.
English: OAT3 mediated transport of sitagliptin was inhibited in vitro by probenecid, although the risk of clinically meaningful interactions is considered to be low.
Slovenian: In vitro je probenecid zaviral transport sitagliptina, ki ga uravnava OAT3, čeprav se smatra, da je tveganje za klinično pomembne interakcije majhno.
English: If you stop taking Ristaben
Slovenian: Če ste prenehali jemati zdravilo Ristaben
English: For adult patients with type 2 diabetes mellitus, Ristaben is indicated to improve glycaemic control:
Slovenian: Pri odraslih bolnikih s sladkorno boleznijo tipa 2 je zdravilo Ristaben indicirano za izboljšanje urejenosti glikemije:
English: Baseline HbA1c was 8.74 % and baseline insulin dose was 37 IU/day.
Slovenian: Začetna vrednost HbA1c je znašala 8,74 %, začetni odmerek insulina pa je bil 37 i.e./dan.
English: Sitagliptin was modestly removed by haemodialysis (13.5 % over a 3- to 4-hour haemodialysis session starting 4 hours postdose).
Slovenian: Sitagliptin se je zmerno odstranil s hemodializo (13,5 % pri 3- do 4-urni hemodializi, ki se začne 4 ure po odmerku).
English: The clinical relevance of hOAT-3 in sitagliptin transport has not been established.
Slovenian: Klinični pomen hOAT-3 pri transportu sitagliptina ni bil dokazan.
English: Animal studies have shown excretion of sitagliptin in breast milk.
Slovenian: Študije na živalih so pokazale, da se sitagliptin izloča v mleko.
English: Since hepatotoxicity has been shown to correlate with induction of hepatic neoplasia in rats, this increased incidence of hepatic tumours in rats was likely secondary to chronic hepatic toxicity at this high dose.
Slovenian: Ker je bila pri podganah dokazana povezava med hepatotoksičnostjo in indukcijo jetrnih neoplazij, je bila pojavnost jetrnih tumorjev pri podganah najverjetneje povečana zaradi kronične hepatotoksičnosti pri tem velikem odmerku.
English: This medicine can be used alone or in combination with certain other medicines (insulin, metformin, sulphonylureas, or glitazones) that lower blood sugar, which you may already be taking for your diabetes together with a food and exercise plan.
Slovenian: To zdravilo se lahko uporablja samo ali v kombinaciji z določenimi drugimi zdravili za zniževanje krvnega sladkorja (insulinom, metforminom, sulfonilsečninami ali glitazoni), ki jih za zdravljenje sladkorne bolezni morda že jemljete ob sočasni načrtovani prehrani in telesni aktivnosti.