FrancophonIA/ELRC3.0 huggingface dataset:
English: One patient out of 1468 patients who received Plegridy in clinical studies experienced an injection site necrosis which resolved with standard medical treatment.
Croatian: Jedan bolesnik od 1468 bolesnika koji su primali Plegridy u kliničkim ispitivanjima razvio je nekrozu na mjestu injiciranja što je uklonjeno standardnim liječenjem.
English: A treatment effect was observed as early as 6 months, with Plegridy 125 micrograms every 2 weeks demonstrating a 61% reduction (p<0.0001) in new or newly enlarging T2 lesions as compared with placebo.
Croatian: Učinak liječenja uočen je već nakon 6 mjeseci, pri čemu je primjena 125 mikrograma Plegridyja svaka dva tjedna pokazala smanjenje od 61% (p<0,0001) novih ili novo povećanih T2 lezija u usporedbi s placebom.
English: Preparing for your injection Step 1: Remove your pen from the fridge.
Croatian: Priprema za injekciju 1. korak: Izvadite brizgalicu iz hladnjaka a.
English: If you forget to use Plegridy
Croatian: Ako ste zaboravili primijeniti Plegridy
English: Treatment should be initiated under supervision of a physician experienced in the treatment of multiple sclerosis.
Croatian: 4.2 Doziranje i način primjene Liječenje treba započeti pod nadzorom liječnika koji ima iskustva u liječenju multiple skleroze.
English: Table 1: Titration schedule at initiation Dose
Croatian: Raspored titracije kod započinjanja
English: Proportion with 24-week confirmed disability progression*
Croatian: Udio s potvrđenom progresijom onesposobljenosti u 24. tjednu* HR
English: An open-label study in patients switching from interferon beta therapy to Plegridy evaluated the onset and duration of prophylactically treated flu-like symptoms.
Croatian: U otvorenom ispitivanju provedenom u bolesnika koji su prebačeni s terapije interferonom beta na Plegridy procijenjeni su početak i trajanje profilaktički liječenih simptoma nalik gripi.
English: • Let the injection site dry before injecting the dose.
Croatian: • Pustite da se mjesto za injekciju osuši prije ubrizavanja doze.
English: The incidence of potentially clinically significant decreases in RBC counts (<3.3 x 1012/L) was similar in Plegridy-treated patients compared to placebo-treated patients.
Croatian: Incidencija potencijalno klinički značajnog smanjenja broja crvenih krvnih stanica (<3,3 x 1012/l) bila je slična u bolesnika liječenih Plegridyjem u usporedbi s bolesnicima koji su dobivali placebo.
English: Patients should be advised to rotate sites for subcutaneous injections.
Croatian: Bolesnike treba savjetovati da mijenjaju mjesta davanja supkutanih injekcija.
English: Pharmacotherapeutic group: Antineoplastic and immunomodulating agents, immunostimulants, interferons, ATC code: L03AB13
Croatian: Farmakoterapijska skupina: Antineoplastici i imunomodulatori, imunostimulansi, interferoni,
English: Laboratory findings suggestive of TMA include decreased platelet counts, increased serum lactate dehydrogenase (LDH) due to haemolysis and schistocytes (erythrocyte fragmentation) on a blood film.
Croatian: Laboratorijski nalazi koji upućuju na TMA, uključuju smanjen broj trombocita, povećanu razinu laktat dehidrogenaze (LDH) u serumu zbog hemolize i shistocite (fragmentirani eritrociti) u krvnom razmazu.
English: Plegridy should be administered with caution to patients with previous depressive disorders (see section 4.3).
Croatian: Plegridy treba primjenjivati s oprezom kod bolesnika s prethodnim depresivnim poremećajima (vidjeti dio 4.3).
English: Depression occurs with increased frequency in the multiple sclerosis population and in association with interferon use.
Croatian: U populaciji s multiplom sklerozom depresija se javlja s povećanom učestalosti i povezana je s primjenom interferona.
English: - If you are unsure of the number of days you have kept a syringe out of the fridge, throw the syringe away.
Croatian: Ako niste sigurni koliko je dugo štrcaljka bila izvan hladnjaka, tada bacite tu štrcaljku.
English: A pre-filled syringe of Plegridy is contained within a single-use, disposable, spring-powered pen injector called Plegridy Pen.
Croatian: Napunjena štrcaljka Plegridyja nalazi se unutar brizgalice za jednokratnu uporabu s oprugom, nazvane Plegridy Pen.
English: The usual sites for subcutaneous injections include abdomen, arm, and thigh.
Croatian: Uobičajena mjesta davanja supkutanih injekcija su trbuh, nadlaktice i bedra.
English: Cessation of therapy with Plegridy should be considered (see section 4.8).
Croatian: Treba razmotriti odluku o prekidu liječenja Plegridyjem (vidjeti dio 4.8).
English: Following subcutaneous administration of peginterferon beta-1a in multiple sclerosis patients, the peak concentration was reached between 1 to 1.5 days post-dose.
Croatian: Nakon supkutane primjene peginterferona beta-1a u bolesnika s multiplom sklerozom, vršna koncentracija postignuta je između 1 do 1,5 dana nakon primjene doze.
English: Orange
Croatian: Narančasta
English: Table 2: Study design
Croatian: Tablica 2. Ustroj ispitivanja
English: Caution should be exercised when Plegridy is administered in combination with medicinal products that have a narrow therapeutic index and are largely dependent on the hepatic cytochrome P450 system for clearance, e.g. some classes of antiepileptics and antidepressants.
Croatian: Plegridy treba davati s osobitom pozornošću u kombinaciji s lijekovima koji imaju uzak terapijski indeks i čiji je klirens vrlo ovisan o sustavu jetrenog P450 citokroma, primjerice s nekim skupinama antiepileptika i antidepresiva.
English: Plegridy is to be injected under the skin (subcutaneous injection).
Croatian: Plegridy se ubrizgava pod kožu (potkožna injekcija).
English: Increased concentrations of neopterin were observed in both healthy subjects and multiple sclerosis patients treated with Plegridy, with a sustained and prolonged elevation over 10 days compared to 5 days observed for non-pegylated interferon beta-1a.
Croatian: Povećane koncentracije neopterina zabilježene su i u zdravih ispitanika i u bolesnika s multiplom sklerozom liječenih Plegridyjem, s održanim i produljenim povišenjem tijekom 10 dana u odnosu na 5 dana za nepegilirani interferon beta-1a.
English: A definitive mechanism of action of peginterferon beta-1a in multiple sclerosis (MS) is not known.
Croatian: Mehanizam djelovanja Točan mehanizam djelovanja peginterferona beta-1a u multiploj sklerozi (MS) nije poznat.
English: In multiple sclerosis patients, the t1/2 (mean±SE) of peginterferon beta-1a was 78 ± 15 hours at steady state.
Croatian: U bolesnika s multiplom sklerozom, t1/2 (srednja vrijednost ± SE) peginterferona beta-1a bio je 78 ± 15 sati u stanju dinamičke ravnoteže.
English: Early clinical features include thrombocytopenia, new onset hypertension, fever, central nervous system symptoms (e.g. confusion, paresis) and impaired renal function.
Croatian: Rane kliničke značajke uključuju trombocitopeniju, novonastalu hipertenziju, vrućicu, simptome središnjeg živčanog sustava (npr. konfuzija, pareza) i oštećenje bubrežne funkcije.
English: Upon repeated dosing with peginterferon beta-1a of sexually mature female monkeys, effects on menstrual cycle length and progesterone levels were observed.
Croatian: Nakon ponovljenog doziranja peginterferona beta-1a spolno zrelim ženkama majmuna, zabilježeni su učinci na duljinu trajanja menstrualnog ciklusa i razine progesterona.
English: What Plegridy is and what it is used for
Croatian: Što je Plegridy i za što se koristi
English: Day 0 (63 micrograms)
Croatian: 0. dan (63 mikrograma)
English: After that you will be provided with a maintenance pack containing grey syringes with Plegridy 125 micrograms (for day 28 and then every two weeks).
Croatian: Nakon toga ćete dobiti pakiranje za održavanje liječenja koje sadrži sive štrcaljke s Plegridyjem od 125 mikrograma (za 28. dan te nakon toga svaka dva tjedna).
English: Do not use external heat sources, such as hot water, to warm your pen.
Croatian: Nemojte koristiti vanjske izvore topline poput vruće vode kako biste zagrijali brizgalicu.
English: Influenza like illness
Croatian: Simptomi nalik gripi
English: See below for simple ways to manage these flu-like symptoms if you get them.
Croatian: Ako dobijete te simptome pogledajte dolje opis jednostavnih načina za kontroliranje tih simptoma nalik gripi.
English: Repeated dose toxicology studies were limited to 5 weeks as exposure was greatly diminished from 3 weeks onwards, due to the formation of anti-drug antibodies by rhesus monkeys to human interferon beta-1a.
Croatian: Ispitivanja toksičnosti ponovljenih doza bila su ograničena na 5 tjedana, jer je izloženost bila znatno smanjena od 3. tjedna nadalje zbog stvaranja protutijela protiv lijeka na ljudski interferon beta-1a u rezus majmuna.
English: The most commonly reported adverse reaction leading to discontinuation in patients treated with Plegridy 125 micrograms subcutaneously every 2 weeks was influenza-like illness (<1%).
Croatian: Najčešće prijavljena nuspojava koja je dovela do prekida liječenja u bolesnika liječenih Plegridyjem u dozi od 125 mikrograma supkutanom injekcijom svaka 2 tjedna, bila je bolest nalik gripi (<1%).
English: Solution for injection Multipack: 6 (3 packs of 2) pre-filled pens of 125 micrograms.
Croatian: Otopina za injekciju Višestruko pakiranje: 6 (3 pakiranja od 2) napunjenih brizgalica od 125 mikrograma.
English: The liquid in the medicinal product window must be clear and colourless.
Croatian: Tekućina u prozorčiću za prikaz lijeka mora biti bistra i bezbojna.
English: (may affect more than 1 in 10 people) - Flu-like symptoms.
Croatian: Vrlo česte nuspojave (mogu se pojaviti u više od 1 na 10 osoba) - simptomi nalik gripi.
English: Direct comparative data for Plegridy versus non-pegylated interferon beta or data on efficacy of Plegridy after switching from a non-pegylated interferon beta are not available.
Croatian: Nisu dostupni izravni usporedni podaci za Plegridy naspram nepegiliranog interferona beta ili podaci o djelotvornosti Plegridyja nakon prebacivanja s nepegiliranog interferona beta.
English: • If some areas are too difficult for you to reach, ask a carer who has been trained to help you.
Croatian: • Ako Vam je teško dosegnuti neka područja, zamolite uvježbanog njegovatelja da Vam pomogne.
English: - Do not use this medicine if you notice any of the following: - If the syringe is broken.
Croatian: Nemojte primijeniti ovaj lijek ako primijetite bilo što od sljedećeg:
English: Step 9: Dispose of used Plegridy pen
Croatian: 9. korak: Odlaganje upotrijebljene štrcaljke Plegridyja
English: Step 8: Remove the pre-filled syringe from your injection site
Croatian: 8. korak: Izvucite štrcaljku s mjesta injekcije
English: - Throw away any syringe that is kept out of the fridge for more than 30 days.
Croatian: - Bacite štrcaljku koja je bila izvan hladnjaka više od 30 dana.
English: Do not inject directly into your belly button.
Croatian: Nemojte ubrizgati lijek izravno u pupak.
English: Do not use Plegridy pre-filled syringe past the expiry date.
Croatian: Nemojte koristiti napunjenu štrcaljku Plegridyja nakon datuma isteka roka valjanosti.
English: Elevations in hepatic enzymes have been observed with the use of Plegridy.
Croatian: Uočena su povišenja jetrenih enzima tijekom liječenja Plegridyjem.
English: What Plegridy is
Croatian: Što je Plegridy
English: Do not share the pen with anyone else to avoid giving an infection to them or getting an infection from them.
Croatian: Nemojte ni s kim dijeliti svoju brizgalicu kako ne biste prenijeli ili dobili neku infekciju.
English: The table summarizes ADRs (incidence above placebo and with a reasonable possibility of causality) from 512 patients treated with Plegridy 125 micrograms subcutaneously every 2 weeks and 500 patients who received placebo for up to 48 weeks and post-marketing data.
Croatian: Tablica sažeto prikazuje nuspojave (incidencija veća od placeba i opravdana mogućnost uzročne povezanosti) kod 512 bolesnika liječenih Plegridyjem od 125 mikrograma supkutano svaka 2 tjedna, i 500 bolesnika koji su primali placebo do 48 tjedana, te iz podataka nakon stavljanja lijeka u promet.
English: Plegridy contains sodium
Croatian: Plegridy sadrži natrij
English: If you get some or all of these symptoms: Increased bruising or bleeding Extreme weakness
Croatian: Ako Vam se pojave neki ili svi sljedeći simptomi: - povećano stvaranje modrica ili povećano krvarenje
English: (frequency cannot be estimated from the available data) - Pulmonary arterial hypertension: A disease of severe narrowing of the blood vessels in the lungs resulting in high blood pressure in the blood vessels that carry blood from the heart to the lungs.
Croatian: Nepoznata učestalost (nepoznata učestalost - učestalost se ne može procijeniti na temelju dostupnih podataka) - plućna arterijska hipertenzija: bolest jakog suženja krvnih žila u plućima što rezultira visokim krvnim tlakom u krvnim žilama koje prenose krv iz srca u pluća.
English: One patient treated with Plegridy in clinical trials experienced an injection site necrosis.
Croatian: Jedan bolesnik liječen Plegridyjem u kliničkom ispitivanju razvio je nekrozu na mjestu injiciranja.
English: Take paracetamol or ibuprofen half an hour before your Plegridy injection and continue to take paracetamol or ibuprofen for the duration of your flu-like symptoms.
Croatian: Nastavite uzimati paracetamol ili ibuprofen sve dok Vam traju simptomi nalik gripi.
English: Decreased peripheral blood counts in all cell lines, including rare pancytopenia and severe thrombocytopenia, have been reported in patients receiving interferon beta.
Croatian: Smanjenje broja perifernih krvnih stanica u svim linijama stanica, uključujući i rijetku pancitopeniju i tešku trombocitopeniju, zabilježeno je u bolesnika koji su primali interferon beta.
English: Before use - Parts of Plegridy Pen (Figure A)
Croatian: Prije upotrebe - dijelovi brizgalice Plegridy (Slika A)
English: - Epilepsy or other seizure disorders, not controlled by medicine - Heart problems, which can cause symptoms such as chest pain (angina), particularly after any activity; swollen ankles, shortness of breath (congestive heart failure); or an irregular heartbeat (arrhythmia).
Croatian: Time se smanjuje rizik od reakcija na mjestu davanja injekcije. - epilepsiju ili ostale poremećaje s napadajima, koji nisu kontrolirani lijekovima - tegobe sa srcem, koje mogu uzrokovati simptome poput boli u prsištu (angina), posebno nakon neke aktivnosti; oticanje gležnjeva, nedostatak zraka (kongestivno zatajenje srca); ili nepravilan srčani ritam (aritmiju) - tegobe sa štitnjačom - nizak broj bijelih krvnih stanica ili trombocita, koji mogu uzrokovati povećani rizik od infekcije ili krvarenja
English: Laboratory abnormalities
Croatian: Abnormalnosti u laboratorijskim nalazima
English: For more information see section 5.1.
Croatian: Za više informacija vidjeti dio 5.1. Za cjeloviti popis pomoćnih tvari vidjeti dio 6.1.
English: • 1 Plegridy Pen (see Figure A)
Croatian: • 1 brizgalica Plegridy (pogledajte sliku A)
English: Step 3: Check your Plegridy pen (see Figure C)
Croatian: 3. korak: Provjerite brizgalicu Plegridy (pogledajte sliku C)
English: 83% treatment-naïve patients
Croatian: 83% bolesnika koji prethodno nisu bili liječeni
English: Elevated serum hepatic transaminase levels, hepatitis, autoimmune hepatitis and rare cases of severe hepatic failure have been reported with interferon beta medicinal products.
Croatian: Povišene razine jetrenih transaminaza, hepatitis, autoimuni hepatitis i rijetki slučajevi teškog zatajenja jetre zabilježeni su s lijekovima koji sadrže interferon beta.
English: - If any of these effects trouble you, contact a doctor.
Croatian: Ako primijetite bilo koju od ovih nuspojava, obratite se liječniku.
English: Patients should be monitored for signs of hepatic injury (see section 4.8).
Croatian: Kod bolesnika treba pratiti pojavu znakova oštećenja jetre (vidjeti dio 4.8).
English: Choose the correct pen from a pack.
Croatian: Odaberite ispravnu brizgalicu iz pakiranja
English: No data are available from clinical efficacy/safety studies directly comparing pegylated with non-pegylated interferon beta-1a, or from patients switching between non-pegylated and pegylated interferon.
Croatian: Nema podataka iz ispitivanja za kliničku djelotvornost i sigurnost koja bi izravno uspoređivala pegilirani s nepegiliranim interferonom beta-1a, ili kod bolesnika koji su prebacivani s nepegiliranog na pegilirani interferon.
English: The incidence of cardiovascular events was similar between Plegridy (125 micrograms every 2 weeks) and placebo treatment groups (7% in each group).
Croatian: Incidencija kardiovaskularnih događaja bila je slična između skupine koja je primala Plegridy (125 mikrograma svaka 2 tjedna) i skupine koja je primala placebo (7% u svakoj skupini).
English: Patients should be monitored for signs of hepatic injury and caution exercised when interferons are used concomitantly with other medicinal products associated with hepatic injury (see sections 4.8 and 5.2).
Croatian: Bolesnike treba pratiti na simptome oštećenja jetre, a naročito je potreban oprez ako uzimaju interferone zajedno s drugim lijekovima koji su povezani s oštećenjem jetre (vidjeti dijelove 4.8 i 5.2).
English: • The liquid is coloured, cloudy or contains floating particles.
Croatian: • ako je tekućina obojena, zamućena ili sadrži plutajuće čestice.
English: The other ingredients are: Sodium acetate trihydrate, acetic acid glacial, arginine hydrochloride, polysorbate 20 and water for injections (see Section 2 “Plegridy contains sodium”).
Croatian: Drugi sastojci su: natrijev acetat trihidrat, acetatna kiselina ledena, argininklorid, polisorbat 20 i voda za injekcije (pogledajte dio 2 „Plegridy sadrži natrij“).
English: 1512 patients were randomised to and dosed with 125 micrograms Plegridy injected subcutaneously every 2 (n=512) or 4 (n=500) weeks versus placebo (n=500).
Croatian: Randomizirano je 1512 bolesnika koji su primali dozu od 125 mikrograma Plegridyja injiciranog supkutano svaka 2 (n=512) ili 4 (n=500) tjedna u usporedbi s placebom (n=500).
English: Let the pen warm to room temperature for at least 30 minutes.
Croatian: Ostavite brizgalicu najmanje 30 minuta na sobnoj temperaturi da se zagrije.
English: Mean white blood cell counts remained within normal limits in patients treated with Plegridy.
Croatian: Srednja vrijednost broja leukocita ostala je u granicama normale u bolesnika liječenih Plegridyjem.
English: Plegridy also significantly reduced the risk of relapse by 39% (p=0.0003), the risk of sustained disability progression confirmed at 12 weeks by 38% (p=0.0383) and at 24 weeks (post-hoc analysis) by 54% (p=0.0069), the number of new or newly enlarging T2 lesions by 67% (p<0.0001), the number of Gd-enhancing lesions by 86% (p<0.0001) and the number of new T1 hypointense lesions compared to placebo by 53% (p<0.0001).
Croatian: Plegridy je također značajno smanjio rizik od relapsa za 39% (p=0,0003), rizik od kontinuirane progresije onesposobljenosti potvrđen nakon 12 tjedana za 38% (p=0,0383) i nakon 24 tjedna (post hoc analiza) za 54% (p=0,0069), broj novih ili novo povećanih T2 lezija za 67% (p<0,0001), broj
English: Plegridy can be stored at room temperature (up to 25°C) for up to 30 days as long as it is stored away from light.
Croatian: Plegridy se može čuvati na sobnoj temperaturi (do 25°C) do 30 dana ako se čuva zaštićen od svjetlosti.
English: A single-dose study in healthy subjects and subjects with various degrees of renal impairment (mild, moderate, and severe renal impairment as well as subjects with end state renal disease) showed a fractional increase in AUC (13-62%) and Cmax (42-71%) in subjects with mild (estimated glomerular filtration rate 50 to ≤80 mL/min/1.73m2), moderate (estimated glomerular filtration rate 30 to <50 mL/min/1.73m2), and severe (estimated glomerular filtration rate <30 mL/min/1.73m2) renal impairment, compared to subjects with normal renal function (estimated glomerular filtration rate >80 mL/min/1.73m2).
Croatian: (blago, umjereno i teško oštećenje funkcije bubrega, kao i ispitanici s terminalnim stanjem bubrežne bolesti) pokazali su frakcijsko povećanje AUC-a (13-62%) i Cmax (42-71%) u ispitanika s blagim oštećenjem bubrega (procijenjena stopa glomerularne filtracije 50 do ≤80 ml/min/1,73 m2), umjerenim oštećenjem bubrega (procijenjena stopa glomerularne filtracije 30 do <50 ml/min/1,73 m2) i teškim oštećenjem bubrega (procijenjena stopa glomerularne filtracije <30 ml/min/1,73 m2), u odnosu na ispitanike s normalnom bubrežnom funkcijom (procijenjena stopa glomerularne filtracije
English: - If you are unsure of the number of days you have kept a pen out of the fridge, throw the pen away.
Croatian: Ako niste sigurni koliko je dugo brizgalica bila izvan hladnjaka, tada bacite tu brizgalicu.
English: One injection of Plegridy 125 micrograms every 14 days (every two weeks).
Croatian: Jedna injekcija Plegridyja od 125 mikrograma svakih 14 dana (svaka 2 tjedna).
English: Hepatic transaminase abnormalities
Croatian: Abnormalnosti jetrenih transaminaza
English: Do not touch or blow this area again before giving the injection.
Croatian: Nemojte ponovno dotaknuti to mjesto prije davanja injekcije.
English: Therefore if clinical features of TMA are observed, further testing of blood platelet levels, serum LDH, blood films and renal function is recommended.
Croatian: Stoga, ako su opažena klinička obilježja TMA, peporučuje se daljnje testiranje razine trombocita u krvi, LDH u serumu, krvnih razmaza i bubrežne funkcije.
English: This medicinal product contains less than 1 mmol (23 mg) sodium, that is to say it is essentially “sodium-free”.
Croatian: Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija, tj. zanemarive količine natrija.
English: Plegridy is a clear and colourless solution for injection in a glass pre-filled syringe with an attached needle.
Croatian: Plegridy je bistra i bezbojna otopina za injekciju u staklenoj napunjenoj brizgalici s pričvršćenom iglom.
English: (may affect up to 1 in 100 people) - Hives - Changes in your blood which might cause unexplained bruising or bleeding.
Croatian: Manje česte nuspojave (mogu se pojaviti u manje od 1 na 100 osoba) - koprivnjača - promjene u krvi koji bi mogle izazvati neobjašnjive modrice ili krvarenje
English: This medicine contains less than 1 mmol sodium (23 mg), that is to say it is essentially “sodium-free”.
Croatian: Ovaj lijek sadrži manje od 1 mmol natrija (23 mg), tj. zanemarive količine natrija.
English: Plegridy 125 micrograms every 4 weeks
Croatian: Plegridy 125 mikrograma svaka 4 tjedna
English: You must only inject Plegridy once every 2 weeks.
Croatian: Smijete primijeniti samo jednu injekciju Plegridyja svaka 2 tjedna.
English: The dose indicates the quantity of the interferon beta-1a moiety of peginterferon beta-1a without consideration of the PEG moiety attached.
Croatian: Doza označava količinu interferona beta-1a u peginterferonu beta-1a, bez uzimanja u obzir vezane PEG skupine.
English: - Throw away any pen that is kept out of the fridge for more than 30 days.
Croatian: - Bacite brizgalicu koja je bila izvan hladnjaka više od 30 dana.
English: Do not use your syringe if it has been dropped or is visibly damaged.
Croatian: Nemojte upotrijebiti štrcaljku ako Vam je ispala ili ima vidljiva oštećenja.
English: Do not share your Plegridy pre-filled syringe with anyone else to avoid giving an infection to them or getting an infection from them.
Croatian: Nemojte ni s kim dijeliti svoju napunjenu štrcaljku Plegridyja kako ne biste prenijeli ili dobili neku infekciju.
English: Solution for injection 2 pre-filled syringes 6 pre-filled syringes
Croatian: Otopina za injekciju 2 napunjene štrcaljke 6 napunjenih štrcaljki
English: - Plegridy can be kept outside a fridge at room temperature (up to 25°C) for up to 30 days but it must be kept away from light.
Croatian: - Plegridy se može čuvati izvan hladnjaka na sobnoj temperaturi (do 25°C) do 30 dana, ali se mora čuvati zaštićen od svjetlosti.