FrancophonIA/ELRC3.0 huggingface dataset:
English: The mean (± SD) change in estimated glomerular filtration rate (eGFR) by Cockcroft-Gault method after 144 weeks of treatment was -15.1 ± 16.5 ml/min in the cobicistat-boosted atazanavir plus emtricitabine and tenofovir disoproxil fumarate fixed-dose combination group and -8.0 ± 16.8 ml/min in the ritonavir-boosted atazanavir plus emtricitabine and tenofovir disoproxil fumarate fixed-dose combination group.
Slovenian: Povprečna (± SD) sprememba hitrosti ocenjene glomerularne filtracije (eGFRCG) po Cockcroft-Gaultovi metodi po 144 tednih zdravljenja je bila -15,1 ± 16,5 ml/min za skupino, zdravljeno z atazanavirjem, okrepljenim s kobicistatom, sočasno s fiksno kombinacijo emtricitabina in dizoproksiltenofovirat fumarata, in -8,0 ± 16,8 ml/min za skupino, zdravljeno z atazanavirjem, okrepljenim z ritonavirjem, sočasno s fiksno kombinacijo emtricitabina in dizoproksiltenofovirat fumarata.
English: Data are not available to make recommendations on the use of darunavir/cobicistat or atazanavir/cobicistat with other oral contraceptives than drospirenone/ethinyloestradiol.
Slovenian: Podatki za priporočila o uporabi darunavirja/kobicistata ali atazanavirja/kobicistata z drugimi peroralnimi kontraceptivi kot je drospirenon/etinilestradiol niso na voljo.
English: Etravirine
Slovenian: etravirin
English: See sections 4.2, 4.4, 5.1 and 5.2.
Slovenian: Glejte poglavja 4.2, 4.4, 5.1 in 5.2. 4.2 Odmerjanje in način uporabe
English: In clinical studies, cobicistat was co-administered with atazanavir or darunavir under fed conditions, in accordance with the Summary of Product Characteristics for these agents.
Slovenian: V kliničnih študijah so kobicistat dajali sočasno z atazanavirjem ali darunavirjem po uživanju hrane v skladu s povzetkom glavnih značilnosti zdravila za ti dve učinkovini.
English: Carbamazepine, a potent CYP3A inducer, decreases cobicistat plasma concentrations and that of atazanavir or darunavir, which may result in loss of therapeutic effect and development of resistance.
Slovenian: Karbamazepin, močni induktor CYP3A, zmanjšuje koncentracije kobicistata in atazanavirja ali darunavirja v plazmi, kar lahko povzroči izgubo terapevtskega učinka in razvoj rezistence.
English: > 100,000 copies/ml
Slovenian: Odstotek oseb z virusno obremenitvijo > 100.000 kopij/ml
English: Warfarin
Slovenian: varfarin
English: Contains sunset yellow FCF aluminium lake (E110), see leaflet for further information.
Slovenian: SEZNAM POMOŽNIH SNOVI Vsebuje barvilo sončno rumeno FCF (E110), za dodatne informacije glejte navodilo za uporabo.
English: Cmax (µg/ml)
Slovenian: Cmax (µg/ml) Ctau (µg/ml)
English: Caution is warranted and clinical monitoring is recommended during co-administration.
Slovenian: Med sočasno uporabo je potrebna previdnost, priporoča pa se tudi klinično spremljanje.
English: Concomitant use not recommended
Slovenian: Sočasna uporaba z drugimi zdravili ni priporočljiva
English: All corticosteroids excluding cutaneous products Corticosteroids primarily metabolised by CYP3A (including betamethasone, budesonide, fluticasone, mometasone, prednisone, triamcinolone).
Slovenian: CYP3A (vključno z betametazonom, budezonidom, flutikazonom, mometazonom, prednizonom, triamcinolonom).
English: Virologic success
Slovenian: Virološki neuspeh c
English: Co-administration of cobicistat with medicinal products that inhibit CYP3A may decrease the clearance of cobicistat, resulting in increased cobicistat plasma concentrations (see section 4.5).
Slovenian: Sočasno dajanje kobicistata z zdravili, ki zavirajo CYP3A, lahko zniža očistek kobicistata, kar vodi v zvišane koncentracije kobicistata v plazmi (glejte poglavje 4.5).
English: Musculoskeletal and connective tissue disorders: Uncommon:
Slovenian: Bolezni mišično-skeletnega sistema in vezivnega tkiva: Občasni:
English: ANTIRETROVIRALS
Slovenian: PROTIRETROVIRUSNA ZDRAVILA
English: Concentrations of calcium channel blockers may be increased when co-administered with cobicistat.
Slovenian: Koncentracije zaviralcev kalcijevih kanalčkov se lahko pri sočasni uporabi s kobicistatom zvišajo.
English: (may affect up to 1 in 10 people)
Slovenian: Pogosti neželeni učinki (pojavijo se lahko pri največ 1 od 10 oseb)
English: Co-administration of cobicistat with medicinal products that are strong inducers of CYP3A (such as St. John's wort (Hypericum perforatum), rifampicin, carbamazepine, phenobarbital, phenytoin) may result in decreased plasma concentrations of cobicistat and consequently that of atazanavir or darunavir being boosted, leading to loss of therapeutic effect and possible development of resistance (see section 4.3).
Slovenian: Sočasno dajanje kobicistata in nekaterih zdravil, ki močno inducirajo CYP3A (kot so šentjanževka (Hypericum perforatum)), rifampicin, karbamazepin, fenobarbital, fenitoin) lahko povzroči zmanjšanje koncentracij kobicistata v plazmi in posledično zmanjšanje okrepitve atazanavirja ali darunavirja, kar ima lahko za posledico izgubo terapevtskega učinka in razvoj rezistence (glejte poglavje 4.3).
English: Co-administration of Tybost with medicinal products that are substrates of these transporters can result in increased plasma concentrations of the co-administered medicinal products (see section 4.4).
Slovenian: Sočasna uporaba zdravila Tybost z zdravili, ki so substrati teh prenašalcev, lahko povzroči zvišanje koncentracij sočasno dajanih zdravil v plazmi (glejte poglavje 4.4).
English: Concentrations of voriconazole may increase or decrease when co-administered with cobicistat.
Slovenian: Koncentracije vorikonazola se lahko pri sočasnem dajanju s kobicistatom zvišajo ali znižajo.
English: Each film-coated tablet contains 150 mg cobicistat.
Slovenian: Ena filmsko obložena tableta vsebuje 150 mg kobicistata.
English: Tybost [Outer packaging only]
Slovenian: PODATKI V BRAILLOVI PISAVI Tybost [samo na zunanji ovojnini]
English: Carbamazepine-10,11-epoxide:
Slovenian: karbamazepin-10,11-epoksid: AUC: ↓ 35 %
English: Metabolism and nutrition disorders: Common:
Slovenian: Presnovne in prehranske motnje: Pogosti:
English: The following side effects may occur when taking Tybost with atazanavir.
Slovenian: Pri jemanju zdravila Tybost z atazanavirjem se lahko pojavijo naslednji neželeni učinki.
English: No clinically relevant pharmacokinetic differences due to gender have been identified for cobicistat.
Slovenian: Za kobicistat ni bilo identificirane klinično pomembne farmakokinetične razlike glede na spol.
English: No dose adjustment of cobicistat is required.
Slovenian: Prilagoditev odmerka kobicistata ni potrebna.
English: Co-administration of tenofovir disoproxil with cobicistat is expected to increase tenofovir plasma concentration.
Slovenian: Pričakuje se, da bo sočasna uporaba dizoproksiltenofovirata s kobicistatom zvišala koncentracije tenofovirja v plazmi.
English: AUC: ↑ 525% Cmax: ↑ 384% Cmin: ↑ 394%
Slovenian: 25-O-desacetil-rifabutin: AUC: ↑ 525 % Cmax: ↑ 384 % Cmin: ↑ 394 %
English: Co-administration with cobicistat can increase plasma concentrations of medicinal products that are metabolised by CYP2D6 (see sections 4.3 and 4.4).
Slovenian: Sočasna uporaba s kobicistatom lahko poviša koncentracije zdravil v plazmi, ki jih presnavlja CYP2D6 (glejte poglavji 4.3 in 4.4).
English: C0h (µg/ml)
Slovenian: Cmax (µg/ml) C0h (µg/ml)
English: You must remain under the care of your doctor while taking Tybost.
Slovenian: Pri jemanju zdravila Tybost morate ostati pod zdravniškim nadzorom.
English: Co-administration with cobicistat can increase plasma concentrations of medicinal products that are metabolised by CYP2D6 (see sections 4.3 and 4.5).
Slovenian: Sočasna uporaba s kobicistatom lahko poviša koncentracije zdravil v plazmi, ki jih presnavlja CYP2D6 (glejte poglavji 4.3 in 4.5).
English: AUC: ↑ 43% Cmax: ↑ 40% Cmin: ↑ 51%
Slovenian: karbamazepin: AUC: ↑ 43 % Cmax: ↑ 40 % Cmin: ↑ 51 %
English: Co-administration of neuroleptics with cobicistat may result in increased plasma concentrations of neuroleptics.
Slovenian: Sočasno dajanje nevroleptikov s kobicistatom lahko povzroči zvišanje koncentracij nevroleptikov v plazmi.
English: How to store Tybost
Slovenian: Shranjevanje zdravila Tybost
English: Co-administration of cobicistat in patients receiving medicinal products that are substrates of these transporters may result in increased plasma concentrations of the co-administered medicinal products (see section 4.5).
Slovenian: Sočasna uporaba kobicistata pri bolnikih, ki prejemajo zdravila, ki so substrati teh prenašalcev, lahko povzroči zvišanje koncentracij sočasno dajanih zdravil v plazmi (glejte poglavje 4.5).
English: No clinically relevant pharmacokinetic differences due to ethnicity have been identified for cobicistat.
Slovenian: Za kobicistat ni bilo identificirane klinično pomembne farmakokinetične razlike glede na etnično pripadnost.
English: Co-administration of salmeterol with cobicistat may result in increased plasma concentrations of salmeterol.
Slovenian: Sočasno dajanje s kobicistatom lahko povzroči zvišanje koncentracij salmeterola v plazmi.
English: Co-administration with CYP3Ametabolised corticosteroids is not recommended unless the potential benefit to the patient outweighs the risk, in which case patients should be monitored for systemic corticosteroid effects.
Slovenian: Sočasna uporaba s kortikosteroidi, ki se presnavljajo s pomočjo encimov CYP3A, se ne priporoča, razen kadar možne koristi za bolnika odtehtajo tveganje.
English: Plasma concentrations of, pitavastatin, fluvastatin or pravastatin are expected to increase when co-administered with atazanavir/cobicistat or darunavir/cobicistat.
Slovenian: Pričakuje se, da se bodo plazemske koncentracije pitavastatina, fluvastatina ali pravastatina pri sočasni uporabi z atazanavirjem/kobicistatom ali darunavirjem/kobicistatom zvišale.
English: The steady-state pharmacokinetic parameters of atazanavir were comparable when boosted with cobicistat versus ritonavir (see Table 4).
Slovenian: Parametri farmakokinetike atazanavirja, okrepljenega s kobicistatom, so bili v stanju dinamičnega ravnovesja primerljivi s parametri, pridobljenimi pri okrepitvi z ritonavirjem (glejte preglednico 4).
English: • aching muscles, weakness
Slovenian: • boleče mišice, utrujenost
English: AUC: ↔ Cmax: ↔ Cmin: ↔
Slovenian: kobicistat: AUC: ↔ Cmax: ↔ Cmin: ↔
English: Systemic lidocaine Mexiletine
Slovenian: dizopiramid flekainid sistemski lidokain meksiletin propafenon
English: Atazanavir + ritonavira (n = 26)
Slovenian: atazanavir + ritonavira
English: Co-administration of rifabutin, a potent CYP3A inducer, may significantly decrease cobicistat plasma concentrations.
Slovenian: Sočasno dajanje rifabutina, močnega induktorja CYP3A, lahko pomembno zmanjša koncentracije kobicistata v plazmi.
English: Co-administration of rilpivirine and cobicistat is expected to increase the plasma concentration of rilpivirine.
Slovenian: Pričakuje se, da bo sočasna uporaba rilpivirina in zdravila kobicistata zvišala koncentracije rilpivirina v plazmi.
English: INHALED BETA AGONISTS Salmeterol
Slovenian: INHALIRANI AGONISTI BETA
English: alfuzosin, used to treat an enlarged prostate gland amiodarone, quinidine, used to correct irregular heartbeats dabigatran, used to prevent and treat blood clots carbamazepine, phenobarbital, phenytoin, used to prevent seizures rifampicin, used to prevent and treat tuberculosis and other infections dihydroergotamine, ergometrine, ergotamine, used to treat migraine headache
Slovenian: • če jemljete zdravila, ki vsebujejo kaj od naslednjega: alfuzosin; uporablja se za zdravljenje povečanja prostate amiodaron, kvinidin; uporabljata se za zdravljenje nepravilnega srčnega utripa dabigatran; uporablja se za preprečevanje in zdravljenje krvnih strdkov karbamazepin, fenobarbital, fenitoin; uporabljajo se za preprečevanje epileptičnih napadov rifampicin; uporablja se za preprečevanje in zdravljenje tuberkuloze in drugih okužb dihidroergotamin, ergometrin, ergotamin; uporabljajo se za zdravljenje glavobola zaradi migrene šentjanževka (Hypericum perforatum); rastlinski pripravek, ki se uporablja proti depresiji in tesnobi lovastatin, simvastatin; uporabljata se za nižanje holesterola v krvi pimozid, lurasidon; uporabljata se za zdravljenje nenormalnih misli ali občutkov sildenafil; uporablja se za zdravljenje pljučne arterijske hipertenzije - bolezni pljuč, ki otežuje dihanje peroralno uporabljeni midazolam, triazolam; uporabljata se kot pomoč pri spanju in/ali za lajšanje tesnobe
English: • Talk to your doctor or pharmacist if you have or have had severe liver disease, or if tests have shown problems with your liver.
Slovenian: • Če imate ali ste imeli hudo bolezen jeter ali če testi pokažejo, da imate težave z jetri, se pogovorite z zdravnikom ali farmacevtom.
English: HIV-1 RNA < 50 copies/ml Treatment difference -2.2% (95% CI = -7.4%, 3.0%) -2.1% (95% CI = -8.7%, 4.5%)
Slovenian: -2,2 % (95-odstotni IZ = -7,4 %; 3,0 %)
English: Co-administration of carbamazepine, a potent CYP3A inducer, may significantly decrease cobicistat plasma concentrations.
Slovenian: Sočasno dajanje karbamazepina, močnega induktorja CYP3A, lahko pomembno zmanjša koncentracije kobicistata v plazmi.
English: Co-administration of cobicistat with medicinal products that inhibit CYP3A may result in increased plasma concentration of cobicistat.
Slovenian: Sočasno dajanje kobicistata in nekaterih zdravil, ki zavirajo CYP3A, lahko povzroči zvišanje koncentracij kobicistata v plazmi.
English: AUC: ↑ 822% Cmax: ↑ 1785%
Slovenian: AUC: ↑ 822 % Cmax: ↑ 1785 % Cmin: NI
English: Concentrations of these antiarrhythmic medicinal products may be increased when co-administered with cobicistat.
Slovenian: Koncentracije teh antiaritmičnih zdravil se lahko pri sočasnem dajanju s kobicistatom zvišajo.
English: Estazolam
Slovenian: izpuščaj
English: Data are not available to make recommendations on the use of atazanavir/cobicistat or darunavir/cobicistat with other oral contraceptives.
Slovenian: Za priporočila glede uporabe atazanavirja/kobicistata ali darunavirja/kobicistata z drugimi peroralnimi kontraceptivi ni razpoložljivih podatkov.
English: • amlodipine, digoxin, diltiazem, disopyramide, felodipine, flecainide, lidocaine, metoprolol,
Slovenian: • amlodipin, digoksin, diltiazem, dizopiramid, felodipin, flekainid, lidokain, metoprolol, meksiletin, nikardipin, nifedipin, propafenon, timolol in verapamil; zdravila, ki se uporabljajo za zdravljenje bolezni srca
English: pyrexia, asthenia
Slovenian: pireksija, astenija
English: No dose adjustment of cobicistat is required for patients with renal impairment, including those with severe renal impairment.
Slovenian: Pri bolnikih z ledvično okvaro, vključno s tistimi z hudo ledvično okvaro, prilagoditev odmerka kobicistata ni potrebna.
English: Atazanavir pharmacokinetics parameters
Slovenian: Parametri farmakokinetike atazanavirja atazanavir + kobicistata
English: The pharmacokinetic enhancing effect of cobicistat on darunavir was evaluated in a phase 1 clinical Study GS-US-216-0115 in 31 healthy subjects that were administered darunavir 800 mg in combination with cobicistat 150 mg or ritonavir 100 mg, all once daily, for 10 days.
Slovenian: Učinek farmakokinetične okrepitve, ki ga ima kobicistat na darunavir, so ovrednotili v klinični študiji faze 1 GS-US-216-0115 pri 31 zdravih osebah, ki so 10 dni dobivale darunavir 800 mg v kombinaciji s kobicistatom 150 mg ali ritonavirjem 100 mg, oboje enkrat na dan. Parametri farmakokinetike darunavirja v stanju dinamičnega ravnovesja, okrepljenega s kobicistatom, so bili primerljivi s parametri, pridobljenimi pri okrepitvi z ritonavirjem (glejte preglednico 5).
English: Consult atazanavir Summary of Product Characteristics for dosing recommendations.
Slovenian: Za priporočila o odmerjanju atazanavirja glejte povzetek glavnih značilnosti za atazanavir.
English: myalgia
Slovenian: mialgija
English: Discontinued study drug due to other reasons and last available HIV-1 RNA < 50 copies/mle
Slovenian: Virološki uspeh HIV-1 RNA < 50 kopij/ml
English: Darunavir given with low dose ritonavir may be considered as an alternative.
Slovenian: Kot alternativa lahko pride v poštev dajanje darunavirja z majhnimi odmerki ritonavirja.
English: Gilead Sciences Ireland UC Tel.: + 353 (0) 1 686 1888
Slovenian: Magyarország Gilead Sciences Ireland UC Tel.: + 353 (0) 1 686 1888
English: If drospirenone/ethinyloestradiol is co-administered with atazanavir/cobicistat clinical monitoring is recommended due to the potential for hyperkalemia.
Slovenian: Če se drospirenon/etinilestradiol daje sočasno z atazanavirjem/kobicistatom, se priporoča klinično spremljanje zaradi potencialnega pojava hiperkaliemije.
English: AUC: ↑ 290% Cmax: ↑ 319%
Slovenian: atorvastatin: AUC: ↑ 290 % Cmax: ↑ 319 % Cmin: NI
English: Nevirapine plasma concentrations may be increased when co-administered with cobicistat.
Slovenian: Koncentracije nevirapina v plazmi se lahko pri sočasni uporabi s kobicistatom zvišajo.
English: Caution should be exercised when co-administering cobicistat with pitavastatin.
Slovenian: Pri sočasnem dajanju kobicistata s pitavastatinom je potrebna previdnost.
English: No dose adjustment of cobicistat is required in patients with mild (Child-Pugh Class A) or moderate hepatic impairment (Child-Pugh Class B).
Slovenian: Pri bolnikih z blago (stopnja A po Child-Pughu) ali zmerno (stopnja B po Child-Pughu) jetrno okvaro prilagoditev odmerka kobicistata ni potrebna.
English: Co-administration of cobicistat with medicinal products that are moderate to weak inducers of CYP3A may result in decreased plasma concentration of cobicistat and consequently that of atazanavir or darunavir being boosted, leading to loss of therapeutic effect and possible development of resistance.
Slovenian: Sočasno dajanje kobicistata in nekaterih zdravil, ki zmerno do šibko inducirajo CYP3A, lahko povzroči zmanjšanje koncentracij kobicistata v plazmi in posledično zmanjšanje okrepitve atazanavirja ali darunavirja, kar ima lahko za posledico izgubo terapevtskega učinka in razvoj rezistence.
English: Darunavir 800 mg + cobicistat 150 mg once daily (n = 31)
Slovenian: Parametri farmakokinetike darunavirja darunavir 800 mg + kobicistat 150 mg enkrat na dan (n = 31)
English: Therapeutic monitoring is recommended upon co-administration with Tybost.
Slovenian: Pri sočasni uporabi z zdravilom Tybost se priporoča terapevtsko spremljanje.
English: Alternative corticosteroids which are less dependent on CYP3A metabolism e.g. beclomethasone for intranasal or inhalational use should be considered, particularly for long-term use.
Slovenian: Zlasti pri dolgotrajni uporabi je treba premisliti o uporabi drugih kortikosteroidov, ki so manj odvisni od presnove s pomočjo encimov CYP3A, npr. beklometazona za intranazalno uporabo ali inhaliranje.
English: When co-administering maraviroc and Tybost patients should receive maraviroc 150 mg twice daily.
Slovenian: Pri sočasni uporabi maraviroka in zdravila Tybost morajo bolniki maravirok prejemati v odmerku 150 mg dvakrat na dan. Za več podrobnosti glejte povzetek glavnih značilnosti zdravila za maravirok.
English: No dose adjustment of rilpivirine is required when atazanavir/cobicistat or darunavir/cobicistat are used concomitantly with rilpivirine.
Slovenian: Pri sočasni uporabi atazanavirja/kobicistata ali darunavirja/kobicistata z rilpivirinom odmerka rilpivirina ni treba prilagajati.
English: ANTICONVULSANTS Carbamazepine (200 mg twice daily)/Elvitegravir (150 mg once daily)/Cobicistat (150 mg once daily)
Slovenian: karbamazepin (200 mg dvakrat na dan)/elvitegravir (150 mg enkrat na dan)/kobicistat (150 mg enkrat na dan)
English: ANTICOAGULANTS Dabigatran
Slovenian: ANTIKOAGULANTI
English: Therefore, therapy with cobicistat and darunavir should not be initiated during pregnancy, and women who become pregnant during therapy with cobicistat and darunavir should be switched to an alternative regimen (see sections 4.2 and 4.6).
Slovenian: Zato se zdravljenje s kobicistatom in darunavirjem ne sme uvesti med nosečnostjo; ženske, ki med zdravljenjem s kobicistatom in darunavirjem zanosijo, morajo preiti na drug režim (glejte poglavji 4.2 in 4.6).
English: Therefore, therapy with cobicistat and darunavir should not be initiated during pregnancy, and women who become pregnant during therapy with cobicistat and darunavir should be switched to an alternative regimen (see sections 4.4 and 4.6).
Slovenian: Zato se zdravljenje s kobicistatom in darunavirjem ne sme uvesti med nosečnostjo; ženske, ki med zdravljenjem s kobicistatom in darunavirjem zanosijo, pa morajo preiti na drug režim (glejte poglavji 4.4 in 4.6).
English: CD4+ T-cell count (cells/mm3)b a Plus background regimen of emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg fixed-dose combination b Missing = excluded analysis
Slovenian: 3)b a Plus osnovi režim s fiksno kombinacijo emtricitabina 200 mg in dizoproksiltenofovirata fumarata 300 mg b Manjka = izključena analiza
English: Drospirenone/Ethinyloestradiol (3 mg/0.02 mg single dose)/Atazanavir (300 mg once daily)/Cobicistat (150 mg once daily)
Slovenian: drospirenon/etinilestradi ol (3 mg/0,02 mg enkratni odmerek)/atazanavir (300 mg enkrat dnevno)/kobicistat (150 mg enkrat dnevno)
English: • Talk to your doctor or pharmacist if you have or have had kidney disease, or if tests have shown problems with your kidneys.
Slovenian: • Če imate ali ste imeli bolezen ledvic ali če testi pokažejo, da imate težave z ledvicami, se pogovorite z zdravnikom ali farmacevtom.
English: Alternative or additional contraceptive measures are recommended when oestrogen-based contraceptives are co-administered with darunavir/cobicistat.
Slovenian: Kadar se kontraceptivi, ki temeljijo na estrogenu, dajejo sočasno z darunavirjem/kobicistatom, se priporoča druge ali dodatne kontracepcijske ukrepe.
English: Median baseline plasma HIV-1 RNA (range)
Slovenian: Mediana začetna vrednost HIV-1 RNA (razpon) log10 kopij/ml v plazmi
English: Package leaflet: Information for the patient Tybost 150 mg film-coated tablets cobicistat
Slovenian: IME ZDRAVILA Tybost 150 mg filmsko obložene tablete
English: ORAL CONTRACEPTIVES Drospirenone/Ethinyloestradiol (3 mg/0.02 mg single dose)/ Darunavir (800 mg once daily)/Cobicistat (150 mg once daily)
Slovenian: drospirenon/etinilestradi ol (3 mg/0,02 mg enkratni odmerek)/darunavir (800 mg enkrat dnevno)/kobicistat (150 mg enkrat dnevno)
English: NEUROLEPTICS Perphenazine Risperidone Thioridazine
Slovenian: perfenazin risperidon tioridazin
English: Co-administration of nevirapine and cobicistat is expected to decrease cobicistat plasma concentrations.
Slovenian: Pričakuje se, da bo sočasna uporaba nevirapina in kobicistata zmanjšala koncentracije kobicistata v plazmi.
English: jaundice
Slovenian: zlatenica
English: AUC: ↔ Cmax: ↑ 41% Cmin: ND
Slovenian: AUC: ↔ Cmax: ↑ 41 % Cmin: ni določeno
English: • difficulty sleeping, abnormal dreams, drowsiness, tiredness (fatigue)
Slovenian: • težave s spanjem, nenormalne sanje, dremavost, utrujenost (izčrpanost) Občasni neželeni učinki (pojavijo se lahko pri največ 1 od 100 oseb)
English: If drospirenone/ethinyloestradiol is co-administered with atazanavir/cobicistat or darunavir/cobicistat clinical monitoring is recommended due to the potential for hyperkalemia.
Slovenian: Če se drospirenon/etinilestradiol daje sočasno z atazanavirjem/kobicistatom ali darunavirjem/kobicistatom, se priporoča klinično spremljanje zaradi potencialnega pojava hiperkaliemije.
English: Cobicistat should not be co-administered with colchicine to patients with renal or hepatic impairment.
Slovenian: Bolnikom z ledvično ali jetrno okvaro se kobicistata ne sme dajati sočasno s kolhicinom.
English: If drospirenone/ethinyloestradiol is co-administered with darunavir/cobicistat clinical monitoring is recommended due to the potential for hyperkalemia.
Slovenian: Če se drospirenon/etinilestradiol daje sočasno z darunavirjem/kobicistatom, se priporoča klinično spremljanje zaradi potencialnega pojava hiperkaliemije.
English: Rosuvastatin (10 mg single dose)/Darunavir (800 mg once daily)/Cobicistat (150 mg once daily)
Slovenian: rosuvastatin (10 mg enkratni odmerek)/darunavir (800 mg enkrat dnevno)/kobicistat (150 mg enkrat dnevno)