FrancophonIA/ELRC3.0 huggingface dataset:
English: The final analysis was performed when all patients had reached their 10-year follow-up visit (unless they had a DFS event or were lost to follow up before).
Slovenian: Končna analiza je bila opravljena, ko so vse bolnice prišle na pregled po 10-letnem spremljanju (razen če se jim je prej pojavil dogodek DFS ali so se prej izgubile spremljanju).
English: Docetaxel has been shown in vitro to disrupt the microtubular network in cells which is essential for vital mitotic and interphase cellular functions.
Slovenian: In vitro docetaksel dokazano zmoti celično mikrotubulno mrežje, nujno za mitotično in interfazno celično delovanje.
English: • swelling caused by faulty lymphatic drainage
Slovenian: • otekanje zaradi nepravilne limfatične drenaže,
English: Docetaxel achieves high intracellular concentrations with a long cell residence time.
Slovenian: Docetaksel doseže visoko znotrajcelično koncentracijo in ima dolg čas zadrževanja v celicah.
English: If a dose greater than 190 mg of docetaxel is required, use a larger volume of the infusion vehicle so that a concentration of 0.74 mg/ml docetaxel is not exceeded.
Slovenian: Če je potrebni odmerek večji od 190 mg docetaksela, uporabite več infuzijskega vehikla, tako da končna koncentracija v raztopini za infundiranje ne preseže 0,74 mg docetaksela/ml.
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the label of the vial after Exp.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na zunanji ovojnini in na nalepki na viali poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
English: Patients with 4+ nodes
Slovenian: Bolnice s 4+ bezgavkami
English: If you have any further questions on the use of this medicine, ask your doctor, or hospital pharmacist.
Slovenian: Če imate glede uporabe tega zdravila še kakšna vprašanja, vprašajte zdravnika ali bolnišničnega farmacevta.
English: Very rare cases of hepatitis, sometimes fatal primarily in patients with pre-existing liver disorders, have been reported.
Slovenian: Opisani so zelo redki primeri hepatitisa, včasih s smrtnim izidom, pri bolnikih z že prej obstoječo boleznijo jeter.
English: In addition, physical and chemical in-use stability of the infusion solution prepared as recommended has been demonstrated in non-PVC bags up to 48 hours when stored between 2 to 8°C.
Slovenian: Poleg tega sta fizikalna in kemijska stabilnost med uporabo dokazani za 48 ur pri temperaturi od 2 °C do 8 °C, če je bila raztopina pripravljena v vrečki, ki ne vsebuje PVC in tako kot je priporočeno.
English: Disseminated intravascular coagulation (DIC), often in association with sepsis or multi-organ failure, has been reported.
Slovenian: Poročali so o diseminirani intravaskularni koagulaciji (DIK), pogosto v povezavi s sepso ali multiorgansko odpovedjo.
English: 1-year Survival (%)
Slovenian: 1-letno preživetje (%)
English: The infusion bag solution should be used within 6 hours below 25°C including the one hour infusion to the patient.
Slovenian: Raztopino za infundiranje v infuzijski vreči je treba uporabiti v 6 urah na temperaturi do 25 °C, to vključuje tudi 1 uro infundiranja bolniku.
English: Surgical resection was allowed following chemotherapy, before or after radiotherapy.
Slovenian: Kirurška resekcija je bila dovoljena po kemoterapiji, pred radioterapijo ali po njej.
English: Patients who experience febrile neutropenia and/or neutropenic infection should have their docetaxel dose reduced to 60 mg/m² in all subsequent cycles (see sections 4.4 and 4.8).
Slovenian: Bolnicam, ki se jim pojavi febrilna nevtropenija in/ali nevtropenična okužba, je treba odmerek docetaksela v vseh nadaljnjih ciklih zmanjšati na 60 mg/m2 (glejte poglavji 4.4 in 4.8).
English: Febrile neutropenia and neutropenic infection occurred in 17.2% and 13.5% of patients respectively, regardless of G-CSF use.
Slovenian: Febrilna nevtropenija se je pojavila pri 17,2 % bolnikov, nevtropenična okužba pa pri 13,5 % bolnikov, ne glede na uporabo G-CSF.
English: Primary prophylactic G-CSF was made mandatory in TAC arm after 230 patients were randomised .
Slovenian: Primarna profilaktična uporaba G-CSF je postala v kraku TAC obvezna po randomizaciji 230 bolnic.
English: When combined to docetaxel, the clearance of carboplatin was about 50% higher than values previously reported for carboplatin monotherapy.
Slovenian: V kombinaciji z docetakselom je bil očistek karboplatina približno 50 % večji od vrednosti, opisanih med monoterapijo s karboplatinom.
English: Patients in both treatment arms were to receive 7 weeks of CRT following induction chemotherapy with a minimum interval of 3 weeks and no later than 8 weeks after start of the last cycle (day 22 to day 56 of last cycle).
Slovenian: Bolniki v obeh terapevtskih krakih so po indukcijski kemoterapiji dobili 7 tednov kemoradioterapije; najkrajši presledek je bil 3 tedne in ne več kot 8 tednov po začetku zadnjega cikla (22. do 56. dan zadnjega cikla).
English: It should be used within 6 hours (including the one hour infusion intravenous administration).
Slovenian: Porabiti jo je potrebno v 6 urah (to vključuje tudi 1 uro intravenskega infundiranja bolniku).
English: In case of combination with CYP3A4 inhibitors, the occurrence of docetaxel adverse reactions may increase, as a result of reduced metabolism.
Slovenian: V primeru kombinirane uporabe z zaviralci CYP3A4 se zaradi zmanjšane presnove lahko poveča pojavljanje neželenih učinkov docetaksela.
English: These results are consistent with the pharmacological activity of docetaxel.
Slovenian: Ti izsledki se skladajo s farmakološkim delovanjem docetaksela.
English: The combined administration of docetaxel, cisplatin and 5-fluorouracil in 12 patients with solid tumours had no influence on the pharmacokinetics of each individual medicinal product.
Slovenian: Kombinacija docetaksela, cisplatina in 5-fluorouracila pri 12 bolnikih s čvrstimi tumorji ni vplivala na farmakokinetiko vsakega posameznega zdravila.
English: If you develop acute or worsening problems with your lungs (fever, shortness of breath or cough), please tell your doctor, hospital pharmacist or nurse immediately.
Slovenian: Če se pojavijo akutne težave s pljuči ali pride do poslabšanja simptomov (povišana telesna temperatura, težko dihanje/kratka sapa ali kašelj), takoj obvestite svojega zdravnika, bolnišničnega farmacevta ali medicinsko sestro.
English: The adverse reactions considered to be possibly or probably related to the administration of docetaxel have been obtained in:
Slovenian: Podatki o neželenih učinkih, ki so morda ali verjetno povezani z uporabo docetaksela, so bili zbrani pri:
English: Without primary G-CSF prophylaxis (n = 111) n (%)
Slovenian: Brez primarne profilakse z G-CSF (n = 111) n (%)
English: • decrease in blood pressure; irregular or rapid heart beat
Slovenian: • znižanje krvnega tlaka, nereden ali hiter srčni utrip,
English: Patients treated with TPF experienced significantly less deterioration of their Global health score compared to those treated with PF (p = 0.01, using the EORTC QLQ-C30 scale).
Slovenian: Pri bolnikih, zdravljenih s TPF, se je lestvica globalnega zdravja signifikantno manj poslabšala kot pri tistih, ki so bili zdravljeni s PF (p = 0,01, uporabljena je bila lestvica EORTC QLQ-C30).
English: • For any subsequent appearances of toxicities, or any Grade 4 toxicities, discontinue the docetaxel dose.
Slovenian: • V primeru vsakega ponovnega pojava toksičnih učinkov ali pojava toksičnih učinkov 4.stopnje, odmerek docetaksela prekinite.
English: Hazard Ratio: 1.032 [95% CI: 0.876; 1.216]
Slovenian: razmerje tveganj: 1,032 [95 % IZ: 0,876, 1,216]
English: (49.0-NA)
Slovenian: (49,0-NP)
English: Undesirable effects on the testis observed in rodent toxicity studies suggest that docetaxel may impair male fertility.
Slovenian: Neželeni učinki na moda, opisani v študijah toksičnosti na glodalcih, nakazujejo, da lahko docetaksel prizadene moško plodnost.
English: Patients who have previously experienced a hypersensitivity reaction to paclitaxel may be at risk to develop hypersensitivity reaction to docetaxel, including more severe hypersensitivity reaction.
Slovenian: Pri bolnikih, ki so kdaj imeli preobčutljivostno reakcijo na paklitaksel, lahko obstaja tveganje za pojav preobčutljivostne reakcije na docetaksel, vključno s hujšo preobčutljivostno reakcijo.
English: 2 year Survival (%)
Slovenian: 2-letno preživetje (%)
English: One hundred eighty six patients were randomised to receive docetaxel (100 mg/m2) with or without trastuzumab; 60% of patients received prior anthracycline-based adjuvant chemotherapy.
Slovenian: Stošestinosemdeset (186) bolnic je bilo randomiziranih na prejemanje docetaksela (100 mg/m2) s trastuzumabom ali brez njega; 60 % bolnic je prej dobilo adjuvantno kemoterapijo na osnovi antraciklinov.
English: You may experience side effects of this medicine that may impair your ability to drive, use tools or operate machines (see section 4 Possible side effects).
Slovenian: To zdravilo vam lahko povzroči neželene učinke, ki lahko poslabšajo sposobnost upravljanja vozil, uporabe orodij ali upravljanja strojev (glejte poglavje 4 Možni neželeni učinki).
English: Reversibility data are available among 35.3% of patients who developed neurotoxicity following docetaxel treatment at 100 mg/m² as single agent.
Slovenian: Podatki o reverzibilnosti so na voljo za 35,3 % bolnikov, pri katerih so se po zdravljenju z docetakselom kot monoterapijo v odmerku 100 mg/m2 pojavili nevrotoksični učinki.
English: DFS data were not statistically significant but were still associated with a positive trend in favour of TAC.
Slovenian: Podatki o preživetju brez bolezni niso bili statistično značilni, a so kljub temu kazali pozitiven trend v korist TAC.
English: • interstitial lung disease (inflammation of the lungs causing coughing and difficulty breathing.
Slovenian: • intersticijska bolezen pljuč (vnetje pljuč, ki povzroča kašljanje in težave z dihanjem.
English: Grade 3
Slovenian: 3. stopnja
English: In combination with cisplatin and 5-fluorouracil
Slovenian: V kombinaciji s cisplatinom in 5-fluorouracilom
English: The pharmacokinetic profile of cisplatin administered shortly after docetaxel infusion is similar to that observed with cisplatin alone.
Slovenian: Farmakokinetični profil cisplatina, uporabljenega kmalu po infuziji docetaksela, je podoben kot po uporabi samega cisplatina.
English: The overall objective response rates in the all-randomised population (investigator assessment) were 41.6% (docetaxel + capecitabine) vs. 29.7% (docetaxel alone); p = 0.0058.
Slovenian: Celotna objektivna deleža odziva v vsej randomizirani populaciji (ocena raziskovalca) sta bila 41,6 % (docetaksel + kapecitabin) in 29,7 % (samo docetaksel), p = 0,0058.
English: The effect of prednisone on the pharmacokinetics of docetaxel administered with standard dexamethasone premedication has been studied in 42 patients.
Slovenian: Učinek prednizona na farmakokinetiko docetaksela, ki so ga aplicirali s standardno premedikacijo z deksametazonom so študirali pri 42 bolnikih.
English: For combination with capecitabine, the most frequent treatment-related undesirable effects (≥ 5%) reported in a phase III study in breast cancer patients failing anthracycline treatment are presented (see capecitabine summary of product characteristics).
Slovenian: Pri kombinaciji s kapecitabinom so predstavljeni najpogostejši z zdravljenjem povezani neželeni učinki (≥ 5 %), o katerih so poročali v študiji III faze pri bolnicah z rakom dojke z neuspelim zdravljenjem z antraciklini (glejte povzetek glavnih značilnosti kapecitabina).
English: Lion Court, Farnham Road, Bordon Hampshire, GU35 0NF United Kingdom
Slovenian: Lion Court, Farnham Road, Bordon Hampshire, GU35 0NF Velika Britanija
English: Combination therapy
Slovenian: Kombinirana terapija
English: The amount of alcohol in this medicinal product and the side effects of the product may impair the ability to drive or use machines (see sections 4.4 and 4.8).
Slovenian: Količina alkohola v tem zdravilu in neželeni učinki zdravila lahko poslabšajo sposobnost vožnje in upravljanja strojev (glejte poglavji 4.4 in 4.8).
English: What DOCETAXEL KABI is and what it is used for
Slovenian: Kaj je zdravilo DOCETAKSEL KABI in za kaj ga uporabljamo
English: In cases of overdose, exacerbation of adverse events may be expected.
Slovenian: Pri prevelikih odmerkih je mogoče pričakovati eksacerbacijo neželenih učinkov.
English: Neutropenic complications in patients receiving TAC with or without primary G-CSF prophylaxis (GEICAM 9805)
Slovenian: Nevtropenični zapleti pri bolnicah, ki so prejemale TAC z ali brez primarne profilakse z G-CSF (GEICAM 9805)
English: • fever: if this happens you must tell your doctor immediately
Slovenian: • povišana telesna temperatura: če se vam to zgodi, morate nemudoma povedati zdravniku,
English: There is no relevant use of DOCETAXEL KABI in the paediatric population in the indications breast cancer, non-small cell lung cancer, prostate cancer, gastric carcinoma and head and neck cancer, not including type II and III less differentiated nasopharyngeal carcinoma.
Slovenian: Zdravilo DOCETAKSEL KABI ni primerno za uporabo pri pediatrični populaciji za indikacije rak dojke, nedrobnocelični pljučni rak, rak prostate, karcinom želodca in rak glave in vratu, ne vključujoč manj diferenciiran nazofaringealni karcinom tipa II oz. III.
English: Docetaxel plus trastuzumab1 n = 92
Slovenian: parameter docetaksel in trastuzumab1 n = 92
English: This regimen was administered every three weeks for 4 cycles in case at least a minor response (≥ 25% reduction in bidimensionally measured tumour size) was observed after 2 cycles.
Slovenian: To shemo so uporabljali 4 cikle vsake 3 tedne, če so po 2 ciklih opazili vsaj majhen odziv (≥ 25 % zmanjšanje dvodimenzionalno merjene velikosti tumorja).
English: Disease-free survival (DFS) was the primary efficacy endpoint and Overall survival (OS) was the secondary efficacy endpoint.
Slovenian: Preživetje brez bolezni (DFS) je bilo primarni, celokupno preživetje (OS) pa sekundarni opazovani dogodek učinkovitosti.
English: In vivo, docetaxel is schedule independent and has a broad spectrum of experimental anti-tumour activity against advanced murine and human grafted tumours.
Slovenian: In vivo docetaksel ni odvisen od sheme in ima širok spekter eksperimentalnega protitumorskega delovanja proti napredovalim mišjim in humanim transplantiranim tumorjem.
English: Blood and lymphatic system disorders Rare: bleeding episodes associated with grade 3/4 thrombocytopenia.
Slovenian: Bolezni krvi in limfatičnega sistema: Redki: krvavitve povezane s trombocitopenijo stopnje 3/4.
English: Head and neck cancer
Slovenian: Rak glave in vratu
English: • Induction chemotherapy followed by radiotherapy (TAX 323)
Slovenian: • Indukcijska kemoterapija in nato radioterapija (TAX 323)
English: DOCETAXEL KABI has been prescribed by your doctor for the treatment of breast cancer, special forms of lung cancer (non-small cell lung cancer), prostate cancer, gastric cancer or head and neck cancer: - For the treatment of advanced breast cancer, DOCETAXEL KABI could be administered either alone or in combination with doxorubicin, or trastuzumab, or capecitabine.
Slovenian: Zdravnik vam je zdravilo DOCETAKSEL KABI predpisal za zdravljenje raka dojke, posebne vrste pljučnega raka (nedrobnocelični pljučni rak), raka prostate, raka želodca ali raka glave in vratu: - Za zdravljenje napredovalega raka dojke se lahko zdravilo DOCETAKSEL KABI uporablja sam ali v kombinaciji z doksorubicinom ali trastuzumabom ali kapecitabinom.
English: The use of docetaxel should be confined to units specialised in the administration of cytotoxic chemotherapy and it should only be administered under the supervision of a physician qualified in the use of anticancer chemotherapy (see section 6.6).
Slovenian: Docetaksel se sme uporabljati le v enotah, specializiranih za citotoksično kemoterapijo in samo pod nadzorom zdravnika, izkušenega na področju onkološke kemoterapije (glejte poglavje 6.6).
English: The updated analysis was performed when all patients had reached their 10-year (median follow up time of 10 years and 5 months) follow-up visit (unless they had a DFS event or were lost to follow-up previously).
Slovenian: Posodobljena analiza je bila opravljena, ko so vse bolnice prišle na pregled po 10-letnem (mediani čas spremljanja: 10 let in 5 mesecev) spremljanju (razen če se jim je prej pojavil dogodek DFS ali so se predhodno izgubile spremljanju).
English: The incidence of the following adverse events (all grades): lethargy, stomatitis, neutropenic infection occurred at rates ≥ 10% higher in patients who were 65 years of age or older compared to younger patients.
Slovenian: Incidenca naslednjih neželenih učinkov (vse stopnje)letargije, stomatitisa in nevtropenične okužbe - je bila pri bolnikih, starih 65 let ali več, ≥ 10 % večja kot pri mlajših bolnikih.
English: For patients who experience complicated neutropenia (prolonged neutropenia, febrile neutropenia or infection), G-CSF and dose reduction should be considered (see section 4.2).
Slovenian: Pri bolnicah, ki doživijo komplicirano nevtropenijo (podaljšano nevtropenijo, febrilno nevtropenijo ali okužbo) je potrebno razmisliti o G-CSF in zmanjšanju odmerka (glejte poglavje 4.2).
English: In the case of severe neutropenia (< 500 cells/mm3 for seven days or more) during a course of docetaxel therapy, a reduction in dose for subsequent courses of therapy or the use of appropriate symptomatic measures are recommended (see section 4.2).
Slovenian: Če se med zdravljenjem z docetakselom pojavi huda nevtropenija (< 500 celic/mm3 sedem dni ali več), je med naslednjimi cikli priporočljivo zmanjšati odmerek ali uporabiti ustrezne simptomatske ukrepe (glejte poglavje 4.2).
English: • pneumonia (infection of the lungs)
Slovenian: • pljučnica (okužba pljuč),
English: The recommended dose of docetaxel is 75 mg/m2.
Slovenian: Priporočeno odmerjanje docetaksela je 75 mg/m2.
English: Docetaxel did not influence the binding of digitoxin.
Slovenian: Docetaksel ni vplival na vezavo digitoksina.
English: The primary anticipated complications of overdose would consist of bone marrow suppression, peripheral neurotoxicity and mucositis.
Slovenian: Glavni pričakovani zapleti prevelikega odmerjanja so supresija kostnega mozga, periferni nevrotoksični učinki in mukozitis.
English: Second primary malignancies (including acute myeloid leukemia, myelodysplastic syndrome and non-Hodgkin lymphoma) may occur several months or years after docetaxel-containing therapy.
Slovenian: Drugi primarni malignomi (vključno z akutno mieloično levkemijo, mielodisplastičnim sindromom in ne-Hodgkinovim limfomom) se lahko pojavijo več mesecev ali let po zdravljenju, ki vključuje docetaksel.
English: Median duration of response to chemotherapy ± radiotherapy (months) (95% CI)
Slovenian: Mediano trajanje odziva na kemoterapijo ± radioterapijo (meseci) (95 % IZ)
English: Farnham Road, Bordon Hampshire, GU35 0NF United Kingdom
Slovenian: Farnham Road, Bordon Hampshire, GU35 0NF Velika Britanija
English: In combination with trastuzumab the recommended dose of docetaxel is 100 mg/m2 every three weeks, with trastuzumab administered weekly.
Slovenian: V kombinaciji s trastuzumabom je priporočeni odmerek docetaksela 100 mg/m2 vsake tri tedne, s tedensko aplikacijo trastuzumaba.
English: Following chemotherapy, patients should receive radiotherapy.
Slovenian: Po kemoterapiji morajo bolniki prejeti radioterapijo.
English: Locoregional therapy with radiation was delivered either with a conventional fraction (1.8 Gy - 2.0 Gy once a day, 5 days per week for a total dose of 66 to 70 Gy), or accelerated/hyperfractionated regimens of radiation therapy (twice a day, with a minimum interfraction interval of 6 hours, 5 days per week).
Slovenian: Lokoregionalno terapijo z obsevanjem so aplicirali bodisi s konvecionalno frakcijo (1,8 Gy - 2,0 Gy enkrat na dan, 5 dni na teden v celotnem odmerku 66 do 70 Gy), ali s pospešenimi/ hiperfrakcioniranimi shemami obsevalnega zdravljenja (dvakrat na dan, z minimalnim intervalom med frakcijama 6 ur, 5 dni na teden).
English: Fluid retention is cumulative in incidence and severity (see section 4.4).
Slovenian: Zastajanje tekočine je kumulativno po incidenci in izrazitosti (glejte poglavje 4.4).
English: At the end of chemotherapy, with a minimal interval of 4 weeks and a maximal interval of 7 weeks, patients whose disease did not progress received radiotherapy (RT) according to institutional guidelines for 7 weeks (PF/RT).
Slovenian: Na koncu kemoterapije, z minimalnim intervalom 4 tednov in maksimalnim intervalom 7 tednov, so bolniki, katerih bolezen ni napredovala, 7 tednov prejemali radioterapijo (RT) v skladu s smernicami ustanove (PF/RT).
English: Rare cases of myocardial infarction have been reported.
Slovenian: Poročali so o redkih primerih miokardnega infarkta.
English: All patients who did not have progressive disease were to receive chemoradiotherapy (CRT) as per protocol (TPF/CRT).
Slovenian: Vsi bolniki, ki niso imeli napredujoče bolezni, so dobili kemotradioterapijo (KRT) po protokolu (TPF/KRT).
English: Overall response rate (%):
Slovenian: celotni delež odziva (%)
English: Three docetaxel patients (2%) discontinued the treatment due to fluid retention, whereas 15 doxorubicin patients (9%) discontinued due to cardiac toxicity (three cases of fatal congestive heart failure).
Slovenian: Tri bolnice (2 %), ki so prejemale docetaksel, so zdravljenje prekinile zaradi zastajanja tekočine, 15 prejemnic (9 %) doksorubicina pa ga je prekinilo zaradi kardiotoksičnih učinkov (trije primeri usodnega kongestivnega srčnega popuščanja).
English: Very common: Haematological toxicity was increased in patients receiving trastuzumab and docetaxel, compared with docetaxel alone (32% grade 3/4 neutropenia versus 22%, using NCI-CTC criteria).
Slovenian: Zelo pogosti: Hematoloških toksičnih učinkov je bilo več pri bolnikih, ki so dobivali trastuzumab in docetaksel kot pri tistih, ki so dobivali samo docetaksel (32 % nevtropenije stopnje 3/4 v primerjavi z 22 % po merilih NCI-CTC).
English: All patients who did not have progressive disease were to receive CRT as per protocol (PF/CRT).
Slovenian: Vsi bolniki, ki niso imeli napredujoče bolezni, so dobili KRT po protokolu (PF/KRT).
English: During these two phase III studies, the safety profile of docetaxel was consistent with the safety profile observed in phase II studies (see section 4.8).
Slovenian: Med študijama III. faze se je varnostni profil docetaksela skladal z varnostnim profilom, ugotovljenim v študijah II.
English: To be taken into account in pregnant or breast-feeding women, in children and high-risk groups such as patients with liver disease, or epilepsy.
Slovenian: Vsebnost etanola je treba upoštevati tudi pri nosečnicah, doječih ženskah, otrocih in skupinah z velikim tveganjem, npr. pri bolnikih z boleznijo jeter ali epilepsijo.
English: Additional cautions for use in adjuvant treatment of breast cancer
Slovenian: Dodatna opozorila pri uporabi adjuvantne terapije raka dojke
English: Severe nail disorders are characterised by hypo- or hyperpigmentation and sometimes pain and onycholysis.
Slovenian: Za hudo prizadetost nohtov so značilni hipo- ali hiperpigmentacija in včasih bolečine in oniholiza.
English: Radiation was delivered with megavoltage equipment using once daily fractionation (2 Gy per day, 5 days per week for 7 weeks, for a total dose of 70-72 Gy).
Slovenian: Bolnike so obsevali z megavoltažno opremo s frakcioniranjem enkrat na dan (2 Gy na dan, 5 dni na teden 7 tednov, tako da je bil celotni odmerek 70-72 Gy).
English: Therefore, men being treated with docetaxel are advised not to father a child during and up to 6 months after treatment and to seek advice on conservation of sperm prior to treatment.
Slovenian: Zato je priporočljivo, da moški, ki se zdravijo z docetakselom, ne zaplodijo otroka med zdravljenjem in v obdobju šestih mesecev po koncu zdravljenja ter da pred začetkom zdravljenja poiščejo nasvet glede ohranitve sperme.