FrancophonIA/ELRC3.0 huggingface dataset:
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment.
Croatian: Pojava autoimunih poremećaja (poput Gravesove bolesti i autoimunog hepatitisa) također je bila prijavljena prilikom imunološke reaktivacije; međutim, prijavljeno vrijeme do nastanka je jako varijabilno, te ovi događaji mogu nastati puno mjeseci nakon početka liječenja.
English: In HIV infected patients with severe immune deficiency at the time of initiation of CART, an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Croatian: U bolesnika zaraženih HIV-om s teškom imunodeficijencijom u vrijeme započinjanja liječenja CART-om može nastati upalna reakcija na asimptomatske ili rezidualne oportunističke patogene.
English: Cases of reversible aseptic meningitis and rare cases of transient cutaneous reactions (including cutaneous lupus erythematosus - frequency unknown) have been observed with human normal immunoglobulin.
Croatian: Kod primjene ljudskog normalnog imunoglobulina zabilježeni su slučajevi reverzibilnog aseptičkog meningitisa i rijetki slučajevi prolaznih kožnih reakcija (uključujući kožni eritemski lupus - učestalost nepoznata).
English: Special warnings and precautions for use
Croatian: Posebna upozorenja i mjere opreza pri uporabi Sindrom imunološke reaktivacije
English: In HIV infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic
Croatian: U bolesnika zaraženih HIV-om s teškom imunodeficijencijom u vrijeme započinjanja liječenja kombiniranom antiretrovirusnom terapijom (CART) može nastati upalna reakcija na asimptomatske ili rezidualne oportunističke patogene i prouzročiti ozbiljna klinička stanja ili pogoršanje simptoma.
English: Do not use after this date.
Croatian: Nemojte koristiti nakon tog datuma.
English: Q1 first quartile; Q3 third quartile
Croatian: Q1 prva kvartila; Q3 treća kvartila
English: Do not use a double dose to make up for a forgotten dose.
Croatian: •Nemojte primijeniti dvostruku dozu kako biste nadoknadili zaboravljenu dozu.
English: Be sure that the powder is completely dissolved.
Croatian: Uvjerite da se prašak u potpunosti otopio.
English: Do not touch the syringe tip with your hand or any surface.
Croatian: Ne dodirujte vrh štrcaljke rukom ili bilo kakvom drugom površinom.
English: * Based on population PK estimates **AUC calculated for a dose of 50 IU/kg
Croatian: * Temeljeno na procjenama populacijske PK **AUC izračunata za dozu od 50 IU/kg
English: a heart disease or are at risk of heart disease.
Croatian: • imate bolest srca ili rizik za bolesti srca.
English: Also factor VIII is an intrinsic protein and not known to cause any reproductive or carcinogenic effects.
Croatian: Također, faktor VIII je intrinzični protein za koji nije poznato da ima bilo kakve reproduktivne ili kancerogene učinke.
English: Date of first authorisation: 18 February 2016
Croatian: Datum prvog odobrenja: 18.02.2016.
English: Hold an unopened vial and also a syringe in your hands to warm it to a comfortable temperature (do not exceed 37 °C).
Croatian: Neotvorenu bočicu, a također i štrcaljku držite u rukama kako biste ih ugrijali do ugodne temperature (ne više od 37 °C).
English: If not used immediately, in use storage times and conditions prior to use are the responsibility of the user.
Croatian: Ako se ne primijeni odmah, vrijeme čuvanja lijeka u primjeni i uvjeti prije primjene odgovornost su korisnika.
English: It is recommended that every time you use Kovaltry, you note down the name and batch number of the product.
Croatian: Preporučuje se da svaki put kad primjenjujete Kovaltry zapišete naziv i broj serije lijeka.
English: The speed of injection should be based on your comfort, but should not be faster than 2 mL per minute.
Croatian: Brzinu injekcije trebate odrediti na temelju ugodnosti, ali ne bi trebala biti veća od 2 ml po minuti.
English: Treatment with Kovaltry will be started by a doctor who is experienced in the care of patients with haemophilia A. Always use this medicine exactly as described in this leaflet and as your doctor or pharmacist has told you.
Croatian: Liječenje lijekom Kovaltry će započeti liječnik koji ima iskustva u liječenju bolesnika s hemofilijom A. Uvijek primijenite ovaj lijek točno onako kako je opisano u ovoj uputi i kako Vam je rekao Vaš liječnik ili ljekarnik.
English: These may be signs of a rare severe sudden allergic reaction to Kovaltry.
Croatian: To mogu biti znakovi rijetke teške iznenadne alergijske reakcije na Kovaltry.
English: Frequencies have been evaluated according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100).
Croatian: Učestalost je procijenjena prema sljedećoj konvenciji: vrlo često (≥ 1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100).
English: Non-clinical data reveal no special risk for humans based on safety pharmacology, in vitro genotoxicity, and short term repeat-dose toxicity studies.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju sigurnosne farmakologije, in vitro genotoksičnosti i kratkotrajnih ispitivanja toksičnosti ponovljenih doza.
English: FVIII inhibition very common (PUPs)* uncommon (PTPs)*
Croatian: Inhibicija faktora VIII vrlo često (PUPs) * manje često (PTPs) *
English: What Kovaltry is and what it is used for
Croatian: Što je Kovaltry i za što se koristi
English: ABR annualised bleed rate
Croatian: ABR = anualizirana stopa krvarenja
English: If a further dose is needed, use a new syringe with product reconstituted as described above.
Croatian: Ako je potrebna druga doza, upotrijebite novu štrcaljku s lijekom pripremljenim kako je opisano u prethodnom tekstu.
English: Of note, annualised bleeding rate (ABR) is not comparable between different factor concentrates and between different clinical studies.
Croatian: Napomena, anualizirana stopa krvarenja (engl. annualized bleed rate, ABR) nije usporediva između različitih koncentrata faktora i između različitih kliničkih ispitivanja.
English: No animal fertility studies have been conducted with Kovaltry and its effect on human fertility has not been established in controlled clinical trials.
Croatian: Nisu provedena ispitivanja plodnosti s lijekom Kovaltry u životinja i njegov učinak na plodnost u ljudi nije ustanovljen u kontroliranim kliničkim ispitivanjima.
English: If any component of the package is opened or damaged, do not use this component.
Croatian: Ako je bilo koji dio sadržan u pakiranju otvoren ili oštećen, nemojte ga uporabiti.
English: Rarely, inhibitors may develop after the first 50 exposure days but continues throughout life although the risk is uncommon.
Croatian: U rijetkim slučajevima razvoj inhibitora može nastupiti nakon prvih 50 dana izloženosti te se nastavlja tijekom cijelog života, premda je rizik manje čest.
English: Follow the instructions for use given by your doctor and provided at the end of this leaflet.
Croatian: Pridržavajte se uputa za uporabu koje Vam je dao liječnik i koje su navedene na kraju ove upute o lijeku.
English: Repeated PK measurements after 6 to 12 months of prophylaxis treatment with Kovaltry did not indicate any relevant changes in PK characteristics after long-term treatment.
Croatian: Ponovljena PK mjerenja nakon 6 do 12 mjeseci profilaktičkog liječenja lijekom Kovaltry nisu ukazivala na nikakve značajne promjene PK obilježja nakon dugotrajnog liječenja.
English: Kovaltry does not contain von Willebrand factor.
Croatian: Kovaltry ne sadrži von Willebrandov faktor.
English: In general, all patients treated with coagulation factor VIII products should be carefully monitored for the development of inhibitors by appropriate clinical observations and laboratory tests (see section 4.2).
Croatian: Općenito, sve bolesnike liječene lijekovima koji sadrže koagulacijski faktor VIII potrebno je pažljivo pratiti na razvoj inhibitora pomoću odgovarajućih kliničkih pregleda i laboratorijskih testova (vidjeti dio 4.2).
English: What Kovaltry is and what it is used for What you need to know before you use Kovaltry How to use Kovaltry
Croatian: Što je Kovaltry i za što se koristi Što morate znati prije nego počnete primjenjivati Kovaltry Kako primjenjivati Kovaltry
English: What Kovaltry looks like and contents of the pack
Croatian: Kako Kovaltry izgleda i sadržaj pakiranja
English: Set the syringe aside for further use.
Croatian: Štrcaljku odložite sa strane za kasniju uporabu.
English: • whether you have inhibitors and how high their level is
Croatian: • prisutnost inhibitora i njihova razina
English: Ask your pharmacist or physician how to throw away medicines you no longer use.
Croatian: Pitajte svog ljekarnika ili liječnika kako baciti lijekove koje više ne koristite.
English: For 250/500/1000 IU strength
Croatian: Za jačinu 250/500/1000 IU:
English: The specific activity of Kovaltry is approximately 4000 IU/mg protein.
Croatian: Specifična aktivnost lijeka Kovaltry je približno 4000 IU/mg proteina.
English: Determine the point of injection and clean the skin with an alcohol swab.
Croatian: Odredite mjesto ubrizgavanja i očistite kožu jastučićem natopljenim alkoholom.
English: If this happens, please contact your doctor immediately.
Croatian: Ako se to dogodi, odmah se obratite liječniku.
English: The new expiry date must be noted on the outer carton when the medicine is removed from the refrigerator.
Croatian: Novi datum isteka roka valjanosti mora se zabilježiti na vanjskoj kutiji kad se lijek izvadi iz hladnjaka.
English: Kovaltry is prepared without the addition of any human or animal derived protein in the cell culture process, purification or final formulation.
Croatian: Kovaltry je pripremljen bez dodavanja bilo kojeg proteina ljudskog ili životinjskog porijekla tijekom dobivanja u staničnoj kulturi, pročišćavanja ili završne formulacije.
English: Pharmacotherapeutic group: antihemorrhagics: blood coagulation factor VIII, ATC code B02BD02.
Croatian: Farmakoterapijska skupina: antihemoragici: krvni koagulacijski faktor VIII, ATK oznaka: B02BD02
English: Do not increase the dose of Kovaltry to control your bleeding without checking with your doctor.
Croatian: Nemojte povećavati dozu lijeka Kovaltry kako biste kontrolirali krvarenje bez provjere s liječnikom.
English: The powder is dry and white to slightly yellow .
Croatian: Prašak je suh i bijel do žućkast.
English: For 2000/3000 IU strength
Croatian: Za jačinu 2000/3000 IU:
English: Since Kovaltry is a replacement protein of endogenous factor VIII, no adverse effects on fertility are expected.
Croatian: Budući da je Kovaltry protein koji nadomješta endogeni faktor VIII, ne očekuju se štetni učinci na plodnost.
English: Kovaltry is prepared by recombinant technology without addition of any human- or animal derived components in the manufacturing process.
Croatian: Kovaltry se proizvodi rekombinantnom tehnologijom bez dodavanja sastojaka ljudskog ili životinjskog porijekla tijekom procesa proizvodnje.
English: If you stop using Kovaltry Do not stop using Kovaltry without checking with your doctor.
Croatian: Ako prestanete primjenjivati Kovaltry Nemojte prestati uzimati Kovaltry bez provjere s liječnikom.
English: The most serious side effects are allergic reactions or severe allergic reaction.Stop injecting Kovaltry immediately and speak to your doctor at once if such reactions occur.
Croatian: Najozbiljnije nuspojave su alergijske reakcije ili teška alergijska reakcija Ako nastupi takva reakcija, odmah prekinite ubrizgavanje lijeka Kovaltry i što prije se javite liječniku.
English: BW: Body weight *Success rate defined as % of bleeds treated successfully with ≤ 2 infusions
Croatian: TT: tjelesna težina * Stopa uspjeha definirana kao % uspješno izliječenih krvarenja s =/< 2 infuzije
English: Kovaltry can be used in children of all ages.
Croatian: Kovaltry se može primjenjivati u djece bilo koje dobi.
English: A population PK model was developed based on all available factor VIII measurements (from dense PK sampling and all recovery samples) throughout the 3 clinical studies allowing calculation of PK parameters for subjects in the various studies.
Croatian: Populacijski PK model razvijen je na temelju svih dostupnih mjerenja FVIII (iz učestalog uzorkovanja za PK analizu i svih uzoraka u kojihje došlo do prirasta (engl. recovery samples) ) tijekom 3 klinička ispitivanja što je omogućilo izračun PK parametara za ispitanike u različitim ispitivanjima.
English: • one pre-filled syringe with 2.5 mL (for 250 IU, 500 IU and 1000 IU) or 5 mL (for 2000 IU and
Croatian: • jednu napunjenu štrcaljku s 2,5 ml (za 250 IU, 500 IU i 1000 IU) ili 5 ml (za 2000 IU i
English: Two multi-centre, open-label, cross-over, uncontrolled, randomised studies in previously treated adults/adolescents with severe haemophilia A (< 1%) and one multi-centre, open-label, uncontrolled study in previously treated children < 12 years with severe haemophilia A were conducted.
Croatian: Provedena su dva multicentrična otvorena, ukrižena, nekontrolirana, randomizirana ispitivanja u prethodno liječenih odraslih osoba/adolescenata s teškom hemofilijom A (< 1%) i jedno multicentrično, otvoreno nekontrolirano ispitivanje u prethodno liječene djece < 12 godina s teškom hemofilijom A.
English: The risk of developing inhibitors is correlated to the severity of the disease as well as the exposure to factor VIII , this risk being highest within the first 20 exposure days.
Croatian: Rizik od razvijanja inhibitora u korelaciji je s težinom bolesti, kao i s izloženošću faktoru VIII, a najveći je unutar prvih 20 dana izloženosti.
English: To treat a bleed, your doctor will calculate and adjust your dose and how often it should be given, depending on factors such as:
Croatian: Za liječenje krvarenja, liječnik će Vam izračunati i prilagoditi dozu i učestalost primjene lijeka ovisno o čimbenicima kao što su:
English: For long term prophylaxis against bleeding in patients with severe haemophilia A, the usual doses for adolescents (≥ 12 years age) and adult patients are 20 to 40 IU of Kovaltry per kg body weight two to three times per week.
Croatian: Za dugotrajnu profilaksu krvarenja u bolesnika s teškom hemofilijom A uobičajene doze za adolescente (≥ 12 godina starosti) i odrasle bolesnike su 20 do 40 IU lijeka Kovaltry po kilogramu tjelesne težine dva do tri puta tjedno.
English: Each single package of Kovaltry contains:
Croatian: Jedno pojedinačno pakiranje lijeka Kovaltry sadrži:
English: Hold a pad firmly over the injection site on your outstretched arm for about 2 minutes.
Croatian: Na ispruženoj ruci čvrsto držite jastučić na mjestu ubrizgavanja tijekom otprilike 2 minute.
English: The following table can be used to guide dosing in bleeding episodes and surgery:
Croatian: Sljedeća tablica može poslužiti kao vodič za doziranje tijekom u epizodama krvarenja te kirurgiji:
English: Bayer HealthCare LLC 800 Dwight Way Berkeley
Croatian: Bayer HealthCare LLC 800 Dwight Way Berkeley, CA 94710 SAD
English: Kovaltry should be injected intravenously over 2 to 5 minutes depending on the total volume.
Croatian: Kovaltry se injicira intravenski tijekom 2 do 5 minuta, ovisno o ukupnom volumenu.
English: Do not use this medicine after the expiry date which is stated on labels and cartons.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na naljepnicama i kutijama.
English: The FVIII:C of Kovaltry can be measured in plasma with a one-stage coagulation assay as well as with a chromogenic assay using the routine methods of the laboratory.
Croatian: FVIII:C za lijek Kovaltry može se mjeriti u plazmi jednostupanjskim testom koagulacije kao i kromogenim testom primjenom rutinskih metoda u laboratoriju.
English: What you need to know before you use Kovaltry
Croatian: Što morate znati prije nego počnete primjenjivati Kovaltry
English: If you are using Kovaltry to prevent bleeding, your doctor will calculate the dose for you.
Croatian: Ako Kovaltry primjenjujete za prevenciju krvarenja, liječnik će Vam izračunati potrebnu dozu.
English: No cases of overdose have been reported.
Croatian: Nisu zabilježeni simptomi predoziranja.
English: The Pharmacokinetic (PK) profile of Kovaltry was evaluated in PTPs with severe haemophilia A following 50 IU/kg in 21 subjects ≥ 18 years, 5 subjects ≥ 12 years and < 18 years and 19 subjects < 12 years of age.
Croatian: Farmakokinetički (PK) profil lijeka Kovaltry procijenjen je u prethodno liječenih bolesnika s teškom hemofilijom A nakon primjene 50 IU/kg u 21 ispitanika ≥ 18 godina, 5 ispitanika ≥ 12 godina i < 18 godina te 19 ispitanika < 12 godina.
English: If you have been told by your doctor that you have developed factor VIII inhibitors you may need to use a larger dose of Kovaltry to control bleeding.
Croatian: Ako Vas je liječnik obavijestio da su se razvili inhibitori faktora VIII, možda će za kontrolu krvarenja biti potrebna veća doza lijeka Kovaltry.
English: It is unknown whether Kovaltry is excreted in human milk.
Croatian: Nije poznato izlučuje li se Kovaltry u majčino mlijeko.
English: Laboratory tests at suitable intervals help to ensure you always have adequate factor VIII levels.
Croatian: Provođenje laboratorijskih testova u odgovarajućim vremenskim razmacima pridonosi tome da se osigura stalna prisutnost odgovarajuće razine faktora VIII.
English: Kovaltry is not likely to affect the fertility in male or female patients, as the active substance is naturally occurring in the body.
Croatian: Utjecaj lijeka Kovaltry na mušku ili žensku plodnost nije vjerojatan, budući da se djelatna tvar prirodno nalazi u tijelu.
English: Table 1: Guide for dosing in bleeding episodes and surgery Degree of haemorrhage/
Croatian: Tablica 1: Vodič za doziranje u epizodama krvarenja te kirurgiji Stupanj krvarenja / vrsta kirurškog zahvata
English: In an international study involving 41 clinical laboratories, the performance of Kovaltry in FVIII:C assays was evaluated and compared to a marketed full length rFVIII product.
Croatian: U internacionalnom ispitivanju u kojem je sudjelovao 41 klinički laboratorij procijenjena je učinkovitost lijeka Kovaltry pri korištenju FVIII:C testova te je uspoređena s lijekom na tržištu koji sadrži rFVIII pune duljine.
English: For children not previously treated with factor VIII medicines, inhibitor antibodies (see section 2) may form very commonly (more than 1 in 10 patients).
Croatian: Za djecu koja prethodno nisu liječena lijekovima s faktorom VIII, inhibitorna antitijela (pogledajte dio 2) mogu se stvarati vrlo često (više od 1 na 10 bolesnika).
English: You will need alcohol swabs, gauze pads, plasters and tourniquet.
Croatian: Bit će Vam potrebne komprese natopljene alkoholom, jastučići gaze i flasteri.
English: If you forget to use Kovaltry
Croatian: Ako ste zaboravili primijeniti Kovaltry
English: For patients who have received previous treatment with factor VIII (more than 150 days of treatment) inhibitor antibodies (see section 2) may form uncommonly (less than 1 in 100 patients).
Croatian: Za bolesnike koji su primali raniju terapiju s faktorom VIII (više od 150 dana liječenja) inhibitorna antitijela (pogledajte dio 2) mogu se stvarati manje često (manje od 1 na 100 bolesnika).
English: Other medicines and Kovaltry Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: Kovaltry is used to treat and prevent bleeding in adults, adolescents and children of all ages with haemophilia A (hereditary factor VIII deficiency).
Croatian: Kovaltry se koristi za liječenje i prevenciju krvarenja u odraslih, adolescenata i djece bilo koje dobi s hemofilijom A (nasljedni nedostatak faktora VIII).
English: Hold the syringe upright and push the plunger until no air is left in the syringe.
Croatian: Držite štrcaljku uspravno te potiskujte klip dok iz štrcaljke ne izađe sav zrak.
English: bleeding that is not being controlled with your usual dose of Kovaltry.
Croatian: • imate krvarenje koje se ne zaustavlja uobičajenom dozom lijeka Kovaltry.
English: What Kovaltry contains
Croatian: Što Kovaltry sadrži
English: Individual patients may vary in their response to factor VIII, demonstrating different half-lives and recoveries.
Croatian: Pojedini bolesnici mogu različito reagirati na faktor VIII, pokazujući različitu duljinu poluvijeka i oporavak (engl. recovery).
English: If patients experience dizziness or other symptoms affecting their ability to concentrate and react, it is recommended that they do not drive or use machines until the reaction subsides.
Croatian: Ako bolesnici imaju vrtoglavicu ili druge simptome koji utječu na njihovu sposobnost koncentracije i reagiranja, preporuča se da ne upravljaju vozilima niti ne rade sa strojevima dok se reakcija ne povuče.
English: Haemophilic patients with cardiovascular risk factors or diseases may be at the same risk to develop cardiovascular events as non-haemophilic patients when clotting has been normalised by treatment with factor VIII.
Croatian: Bolesnici s hemofilijom i kardiovaskularnim faktorima rizika ili bolestima mogu imati isti rizik od razvoja kardiovaskularnih događaja kao i bolesnici koji nemaju hemofiliju kad se koagulacija krvi normalizira liječenjem s faktorom VIII.
English: During the course of treatment, appropriate determination of factor VIII levels is advised to guide the dose to be administered and the frequency of repeated infusions.
Croatian: Tijekom trajanja liječenja savjetuje se odgovarajuće određivanje razina faktora VIII kako bi se regulirala primijenjena doza i učestalost ponavljajućih infuzija.
English: This medicine may be stored at room temperature (up to 25 °C) for up to 12 months when you keep it in its outer carton.
Croatian: Ovaj se lijek može držati na sobnoj temperaturi (do 25 °C) najviše 12 mjeseci ako ga držite u vanjskoj kutiji.
English: Each vial of Kovaltry contains nominally 250, 500, 1000, 2000 or 3000 IU octocog alfa.
Croatian: Svaka bočica lijeka Kovaltry sadrži nominalno 250, 500, 1000, 2000 ili 3000 IU oktokoga alfa.
English: Development of neutralising antibodies (inhibitors) may occur in patients with haemophilia A treated with factor VIII (FVIII), including with Kovaltry.
Croatian: Do razvoja neutralizirajućih antitijela (inhibitora) može doći u bolesnika s hemofilijom A koji su liječeni faktorom VIII (FVIII), uključujući Kovaltry.
English: Multipack with 30 single packs, each containing:
Croatian: Višestruko pakiranje s 30 pojedinačnih pakiranja, a u svakom je:
English: Do not use Kovaltry if you notice visible particulate matter or turbidity.
Croatian: Kovaltry nemojte koristiti ako zamijetite vidljive čestice ili zamućenje.
English: No symptoms of overdose with recombinant human coagulation factor VIII have been reported.
Croatian: Nisu zabilježeni simptomi predoziranja rekombinantnim ljudskim koagulacijskim faktorom VIII.
English: Do not use the venipuncture set provided for drawing blood because it contains an in-line filter.
Croatian: Nemojte uporabiti priloženi pribor za venepunkciju za uzimanje krvi, zato što sadrži ugrađeni filter.
English: Apply a tourniquet to your arm.
Croatian: Postavite povesku na ruku.
English: Any unused solution must be discarded.
Croatian: Neiskorištena otopina se mora baciti.
English: EXP (End of the 12 month period, if stored up to 25 °C): ................
Croatian: Rok valjanosti (kraj 12-mjesečnog razdoblja ako se lijek čuva na temperaturi do 25 °C): ...........
English: Use only the components (vial adapter, pre filled syringe containing solvent and venipuncture set) provided with each package of this medicine.
Croatian: Koristite samo pribor (nastavak za bočicu, napunjenu štrcaljku s otapalom i pribor za venepunkciju) koji je priložen u svakom pakiranju ovog lijeka.
English: Duration of treatment Usually, Kovaltry treatment for haemophilia is needed life-long.
Croatian: Trajanje liječenja Liječenje hemofilije lijekom Kovaltry obično traje tijekom cijelog života.