FrancophonIA/ELRC3.0 huggingface dataset:
English: Excretion is primarily biliary, with only 6% of an oral dose excreted in the urine, and with less than 1% in the unchanged form (see sections 4.2 and 4.4).
Danish: Udskillelsen er hovedsageligt biliær, hvor kun 6 % af den orale dosis udskilles med urinen og mindre end 1 % udskilles uomdannet urinen (se pkt.
English: • if you have high levels of potassium in your blood.
Danish: • hvis du har højt kaliumniveau i blodet
English: If you are not sure, talk to your doctor or pharmacist before taking Sandimmum.
Danish: Hvis du er i tvivl, skal du tale med din læge eller apotekspersonalet, inden du tager Sandimmun.
English: Neoplasms benign, malignant and unspecified (including cysts and polyps) Patients receiving immunosuppressive therapies, including ciclosporin and ciclosporin containing regimens, are at increased risk of developing lymphomas or lymphoproliferative disorders and other malignancies, particularly of the skin.
Danish: cyster og polypper) Patienter, der modtager immunsuppressiv behandling, inklusive ciclosporinholdige regimer, har øget risiko for at udvikle lymfomer eller lymfoproliferative sygdomme og andre maligniteter, specielt i huden.
English: OTHER SPECIAL WARNING(S), IF NECESSARY [To be completed nationally]
Danish: EVENTUELLE ANDRE SÆRLIGE ADVARSLER [Udfyldes nationalt]
English: • Nausea (feeling sick), vomiting, abdominal pain, constipation, diarrhoea.
Danish: • Kvalme, opkastning, mavesmerter, forstoppelse, diaré.
English: To achieve initial remission, or to counteract inflammatory ocular attacks, systemic corticosteroid treatment with daily doses of 0.2 to 0.6 mg/kg prednisone or an equivalent may be added if Sandimmun alone does not control the situation sufficiently.
Danish: Der kan suppleres med systemisk kortikosteroid i en dosis på 0,2-0,6 mg prednison /kg/dag eller ækvivalent behandling, hvis Sandimmun ikke er tilstrækkeligt til at fremkalde initialremission eller til at modvirke inflammatoriske episoder i øjet.
English: Ethanol: 25 mg/capsule.
Danish: Ethanol: 25 mg/kapsel.
English: Renal toxicity should be monitored when initiating ciclosporin use together with active substances that increase ciclosporin levels or with substances that exhibit nephrotoxic synergy (see section 4.5).
Danish: Der skal monitoreres for nefrotoksicitet, når behandling med ciclosporin startes, når der samtidig administreres lægemidler, der øger ciclosporinniveauet, eller stoffer, der udviser nefrotoksisk synergi (se pkt.
English: • Digoxin (used to treat heart problems), medicines which lower cholesterol (HMG-CoA reductase inhibitors also called statins), prednisolone, etoposide (used to treat cancer), repaglinide (an anti-diabetic medicine), immunosuppressives (everolimus, sirolimus), ambrisentan and specific anti-cancer medicines called anthracyclines (such as doxorubicin).
Danish: • Digoxin (bruge til behandling af hjertelidelser), kolesterolsænkende medicin (HMG-CoAreduktasehæmmere, som også kaldes statiner), prednisolon, etoposid (bruges til behandling af kræft), repaglinid (til behandling af sukkersyge), medicin, der undertrykker immunforsvaret (everolimus, sirolimus), ambrisentan og bestemte lægemidler mod kræft, som kaldes antracykliner (fx doxorubicin).
English: A frequent and potentially serious complication, an increase in serum creatinine and urea, may occur during Sandimmun therapy.
Danish: I behandlingen med Sandimmun kan stigning i serumkreatinin og urea forekomme som en hyppig og potentielt alvorlig komplikation.
English: Hepatic function abnormal (see section 4.4)
Danish: Almindelig Unormal leverfunktion (se pkt.
English: Caution should be observed while co-administering ciclosporin with such drugs or concomitant use should be avoided (see section 4.5).
Danish: Der bør udvises forsigtighed ved samtidig administration, eller samtidig administration af sådanne lægemidler bør undgås (se pkt.
English: All inducers of CYP3A4 and/or P-glycoprotein are expected to decrease ciclosporin levels.
Danish: Lægemidler, som nedsætter ciclosporinkoncentrationen Alle inducere af CYP3A4 og/eller P-glykoprotein forventes at nedsætte ciclosporinkoncentrationen.
English: Sandimmun should not be given to children for a non-transplant disease, except for treatment of nephrotic syndrome.
Danish: Sandimmun må kun gives til børn i forbindelse med en transplantation eller til behandling af nefrotisk syndrom.
English: • Keep this medicine out of the sight and reach of children.
Danish: • Opbevar dette lægemiddel utilgængeligt for børn.
English: How long to take Sandimmun
Danish: Hvor længe skal du have Sandimmun
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each ampoule contains 50 mg/mL ciclosporin
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver ampul indeholder 50 mg/ml ciclosporin.
English: NAME OF THE MEDICINAL PRODUCT Sandimmun and associated names (see Annex I) 100 mg/ml oral solution [See Annex I - To be completed nationally]
Danish: Sandimmun og relaterede navne (se Bilag I) 100 mg/ml oral opløsning [Se bilag I - Udfyldes nationalt]
English: LIST OF EXCIPIENTS Also contains: Ethanol anhydrous, macrogolglycerol ricinoleate/polyethoxylated castor oil
Danish: LISTE OVER HJÆLPESTOFFER Indeholder også: Vandfri ethanol, polyoxyleret ricinusolie
English: Each ampoule of 5 ml contains 250 mg of ciclosporin.
Danish: Hver ampul på 5 ml indeholder 250 mg ciclosporin.
English: Oral administration
Danish: Administration
English: What you need to know before you take Sandimmun
Danish: Det skal du vide, før du begynder at tage Sandimmun
English: - For more than 1 ml of medicine, use the 4 ml syringe.
Danish: - Til mere end 1 ml skal 4 ml-sprøjten anvendes.
English: What Sandimmun contains
Danish: Sandimmun indeholder:
English: Use of Sandimmun in children for non-transplantation indications other than nephrotic syndrome cannot be recommended (see section 4.4).
Danish: Anvendelse af Sandimmun hos børn til andre indikationer end transplantation syndrom kan ikke anbefales, bortset fra til nefrotisk (se pkt.
English: • The other ingredients are ethanol anhydrous, maize oil interesterified, maize oil refined.
Danish: • De øvrige indholdsstoffer er vandfri ethanol, interesterificeret majsolie, refineret majsolie.
English: Each ampoule of 1 ml contains 50 mg of ciclosporin.
Danish: Hver ampul på 1 ml indeholder 50 mg ciclosporin.
English: Caution is also required when ciclosporin is co-administered with potassium-sparing drugs (e.g. potassiumsparing diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists) or potassium-containing medicinal products as well as in patients on a potassium rich diet. Control of potassium levels in these situations is advisable.
Danish: Der bør også udvises forsigtighed, når ciclosporin indgives sammen med kaliumbesparende lægemidler (f.eks. kaliumbesparende diuretika, ACE-hæmmere, angiotensin II-receptorantagonister) eller lægemidler, som indeholder kalium, samt hos patienter, hvis kost indeholder meget kalium.
English: The concentrate for solution for infusion contains 50 mg/ml.
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING Koncentrat til infusionsvæske indeholder 50 mg/ml.
English: If you are not sure, talk to your doctor before taking Sandimmun.
Danish: Hvis du er i tvivl, skal du tale med lægen, inden du tager Sandimmun.
English: • The other ingredients are: o Capsule content: ethanol anhydrous, maize oil interesterified, maize oil refined.
Danish: • Øvrige indholdsstoffer: o Kapselindhold: vandfri ethanol, interesterificeret majsolie, refineret majsolie.
English: All inhibitors of CYP3A4 and/or P-glycoprotein may lead to increased levels of cyclosporine.
Danish: Lægemidler, som øger ciclosporinkoncentrationen Alle hæmmere af CYP3A4 og/eller P-glykoprotein kan føre til øget ciclosporinkoncentration.
English: Non-transplantation indications
Danish: Andre indikationer end transplantation
English: Regular monitoring of blood pressure is required during Sandimmun therapy.
Danish: Under behandlingen med Sandimmun skal blodtrykket måles regelmæssigt.
English: For inducing remission, the recommended initial dose is 2.5 mg/kg/day orally given in 2 divided doses.
Danish: Til fremkaldelse af remission er den anbefalede orale intialdosis 2,5 mg/kg/dag fordelt på 2 doser.
English: • The other ingredients are: ethanol anhydrous, macrogolglycerol ricinolate/polyethoxynolated castor oil.
Danish: • Øvrige indholdsstoffer: vandfri ethanol, polyoxyleret ricinusolie.
English: Care should be taken when using ciclosporin together with other active substances that exhibit nephrotoxic synergy such as: aminoglycosides (including gentamycin, tobramycin), amphotericin B, ciprofloxacin, vancomycin, trimethoprim (+ sulfamethoxazole); fibric acid derivatives (e.g. bezafibrate, fenofibrate); NSAIDs (including diclofenac, naproxen, sulindac); melphalan histamine H2-receptor antagonists (e.g. cimetidine, ranitidine); methotrexate (see section 4.4).
Danish: Der skal udvises forsigtighed, når ciclosporin anvendes sammen med andre lægemidler, som udviser nefrotoksisk synergi, f.eks.: aminoglycosider (herunder gentamycin, tobramycin), amphotericin B, ciprofloxacin, vancomycin, trimethoprim (+ sulfamethoxazol); fibrater (f.eks. bezafibrat, fenofibrat); NSAIDer (inklusive diclofenac, naproxen, sulindac); melphalan; histamin H2-receptorantagonister (f.eks. cimetidin, ranitidin); methotrexat (se pkt.
English: Co-administration of drugs that are substrates of CYP3A4, P-gp and OATP with ciclosporin may increase plasma levels of co-medications that are substrates of this enzyme and/or transporter.
Danish: Samtidig administration af lægemidler, der er substrater for Cyp3A4, P-gp og OATP, og ciclosporin kan øge plasmakoncentrationen af samtidig administrerede lægemidler, som er substrater af dette enzym og/eller transporter.
English: • Kidney problems.
Danish: • Nyreproblemer.
English: Ethanol: 50 mg/capsule.
Danish: Ethanol: 50 mg/kapsel.
English: Macrogolglycerol ricinoleate/polyethoxylated castor oil
Danish: Ethanol, vandfri Polyoxyleret ricinusolie
English: Medicines which may increase the level of ciclosporin in your blood include: antibiotics (such as erythromycin or azythromycin), anti-fungals (voriconazole, itraconazole), medicines used for heart problems or high blood pressure (diltiazem, nicardipine, verapamil, amiodarone), metoclopramide (used to stop sickness), oral contraceptives, danazol (used to treat menstrual problems), medicines used to treat gout (allopurinol), cholic acid and derivatives (used to treat gallstones), protease inhibitors used to treat HIV, imatinib (used to treat leukaemia or tumours), colchicine, telaprevir (used to treat hepatitis C).
Danish: Medicin, som kan øge mængde af ciclosporin i blodet, bl.a.: antibiotika (fx erythromycin og azithromycin), medicin mod svamp (voriconazol, itraconazol), medicin mod hjerteproblemer eller forhøjet blodtryk (diltiazem, nicardipin, verapamil, amiodaron), metoclopramid (medicin mod kvalme og opkastninger), svangerskabsforebyggende piller, danazol (medicin mod menstruationsproblemer), medicin mod urinsyregigt (allopurinol), cholsyre og -derivater (medicin mod galdesten), proteasehæmmere, der bruges til at behandle HIV, imatinib (medicin mod leukæmi eller svulster), colchicin, telaprevir (medicin mod hepatitis C).
English: Dose reduction may be necessary in patients with severe liver impairment to maintain blood levels within the recommended target range (see sections 4.4 and 5.2) and it is recommended that ciclosporin blood levels are monitored until stable levels are reached.
Danish: 4.4 og 5.2), og det anbefales, at blodkoncentrationen af ciclosporin monitoreres, indtil et stabilt niveau er nået.
English: • Tiredness.
Danish: • Udslæt.
English: Ethanol: 100 mg/capsule.
Danish: Ethanol: 100 mg/kapsel.
English: • Excessive growth of body and facial hair.
Danish: • Kraftig hårvækst på kroppen og i ansigtet.
English: Table 1: Adverse drug reactions from clinical trials Blood and lymphatic system disorders Common
Danish: Tabel 1: Lægemiddelbivirkninger fra kliniske studier
English: Sandimmun contains castor oil Sandimmun contains castor oil, which may cause stomach discomfort and diarrhoea.
Danish: Sandimmun indeholder polyoxyleret ricinusolie Sandimmun indeholder polyoxyleret ricinusolie, som kan give ubehag i maven eller diaré.
English: Hypomagnesaemia
Danish: Hypomagnesiæmi
English: Convulsions, paraesthesia
Danish: Menstruationsforstyrrelser, gynækomasti
English: Pain in your muscles, muscle spasm.
Danish: • Muskelsmerter, muskelkramper.
English: These include: anti-bacterial medicines (gentamycin, tobramycin, ciprofloxacin), anti-fungal medicines which contain amphotericin B, medicines used for urinary tract infections which contain trimethoprim, medicines for cancer which contain melphalan, medicines used to lower the amount of acid in your stomach (acid secretion inhibitors of the H2-receptor antagonist type), tacrolimus, pain killers (non-steroid antiinflammatory medicines such as diclofenac), fibric acid medicines (used to lower the amount of fat in the blood).
Danish: • Medicin, som kan påvirke nyrerne, bl.a.: antibakteriel medicin (gentamycin, tobramycin, ciprofloxacin), medicin mod svamp, som indeholder amphotericin B, medicin mod urinvejsinfektioner, som indeholder trimethoprim, medicin mod kræft, som indeholder melphalan, medicin, som sænker mængden af mavesyre (syresekretionshæmmende medicin af typen H2-receptorantagonister), tacrolimus, smertestillende medicin (NSAID, som fx diclofenac), fibrater (medicin, der bruges til at sænke mængden af fedt i blodet).
English: • Do not store your capsules in a hot place (maximum temperature 30°C).
Danish: • Kapslerne må ikke opbevares ved temperaturer over 30°C.
English: Vascular disorders Very common
Danish: Nyrer og urinveje Meget almindelig
English: This contains 5 mg of ciclosporin.
Danish: Det svarer til 5 mg ciclosporin.
English: For volume less than 1 ml or equal to 1 ml, use the 1-ml syringe.
Danish: Til doser på 1 ml eller mindre skal 1 ml-sprøjten anvendes.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Danish: Brug af anden medicin sammen med Sandimmun Fortæl altid lægen eller på apoteket, hvis du tager anden medicin eller har gjort det for nylig.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each ml contains 100 mg ciclosporin
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver ml indeholder 100 mg ciclosporin.
English: Polyethoxylated castor oil and anaphylactoid reactions Sandimmun concentrate for solution for infusion contains polyethoxylated castor oil, which has been reported to cause anaphylactoid reactions following intravenous administration.
Danish: Polyoxyleret ricinusolie og anafylaktoide reaktioner Sandimmun koncentrat til infusionsvæske indeholder polyoxyleret ricinusolie.
English: For volume greater than 1 ml, use the 4-ml syringe.
Danish: Til doser på mere end 1 ml skal 4 ml-sprøjten anvendes.
English: Discontinuation of Sandimmun may also become necessary if hypertension developing during treatment cannot be controlled by appropriate therapy.
Danish: Seponering af Sandimmun kan være nødvendig, hvis der opstår hypertension under behandlingen, og den ikke kan kontrolleres med passende behandling.
English: Each capsule contains 100 mg ciclosporin.
Danish: Hver kapsel indeholder 100 mg ciclosporin.
English: Except for the treatment of nephrotic syndrome, there is no adequate experience available with Sandimmun.
Danish: Pædiatrisk brug ved andre indikationer end transplantation Med undtagelse af behandling af nefrotisk syndrom, er der utilstrækkelig erfaring med Sandimmun.
English: This contains 10 mg of ciclosporin.
Danish: Det svarer til 10 mg ciclosporin.
English: Capsule contents Ethanol anhydrous Maize oil interesterified Maize oil refined
Danish: Kapselindhold Ethanol, vandfri Majsolie, interesterificeret Majsolie, rafineret
English: Hepatotoxicity and liver injury including cholestasis, jaundice, hepatitis and liver failure with some fatal outcome (see section 4.4) Skin and subcutaneous tissue disorders Very common
Danish: 4.4) Ikke kendt* Hepatotoksicitet og leverskade, inklusive kolestase, gulsot, hepatitis og leversvigt undertiden med fatal udgang (se pkt.
English: • The total dose each day is usually between 3 to 5 mg per kilogram of your weight.
Danish: • Den samlede daglige dosis er typisk mellem 3 til 5 mg pr. kilogram kropsvægt.
English: • High level of sugar in your blood.
Danish: • Højt blodsukker.
English: The total dose each day is usually between 5 mg and 7 mg per kilogram body weight.
Danish: Den totale daglige dosis er sædvanligvis mellem 5 mg og 7 mg pr. kilogram kropsvægt.
English: Sandimmun can also be combined with low-dose weekly methotrexate in patients who have insufficient response to methotrexate alone, by using 2.5 mg/kg Sandimmun in 2 divided doses per day initially, with the option to increase the dose as tolerability permits.
Danish: Sandimmun kan også kombineres med en ugentlig lav dosis methotrexat hos patienter, som ikke reagerer tilstrækkeligt på methotrexat alene.
English: Each capsule contains 25 mg ciclosporin.
Danish: Hver kapsel indeholder 25 mg ciclosporin.
English: The syringe should not be rinsed, but wiped on the outside with a dry tissue to remove remaining drops of the solution (see section 6.6).
Danish: Hvis sprøjten skal rengøres, må den ikke skylles, men aftørres udvendigt med en tør klud (se pkt.
English: Ethanol anhydrous
Danish: Ethanol, vandfri
English: In addition the corresponding frequency category for each adverse drug reaction is based on the following convention (CIOMS III): very common (≥1/10); common (≥1/100,
Danish: Inden for hver enkelt frekvensgruppe er bivirkningerne opstillet efter, hvor alvorlige de er. Frekvenskategorien for hver bivirkning er baseret på følgende konvention (CIOMS
English: Very rare side effects: These side effects may affect between 1 and 10 in every 100,000 people.
Danish: Meget sjældne bivirkninger: Disse bivirkninger kan forekomme hos mellem 1 og 10 ud af 100.000 personer.
English: • if you have liver problems.
Danish: • hvis du har leverproblemer
English: • if you have any liver problems.
Danish: • hvis du har nogen leverproblemer.
English: If any of the above applies to you (or you are not sure), talk to your doctor or pharmacist before taking Sandimmun.
Danish: Hvis noget af det ovenstående gælder for dig (eller hvis du er i tvivl), skal du tale med lægen eller apotekspersonalet, før du tager Sandimmun.
English: How much Sandimmun to take
Danish: Så meget Sandimmun skal du tage
English: Medicines which may decrease the level of ciclosporin in your blood include: barbiturates (used to help you to sleep), some anti-convulsant medicines (such as carbamazepine or phenytoine), octreotide (used to treat acromegaly or neuroendorcrine tumours in the gut), anti-bacterial medicines used to treat tuberculosis, orlistat (used to help weight loss), herbal medicines containing St. John's wort, ticlopidine (used after a stroke), certain medicines which lower blood pressure (bosentan), and terbinafine (an anti-fungal medicine used to treat infections of the toes and nails).
Danish: Medicin, som kan sænke mængden af ciclosporin i blodet, bl.a.: barbiturater (sovemedicin), visse typer medicin mod epilepsi (fx carbamazepin og phenytoin), octreotid (medicin med akromegali eller neuroendokrine svulster i maven), antibakteriel medicin, som bruges til behandling af tuberkulose, orlistat (bruges til at fremme vægttab), naturlægemidler, som indeholder perikon, ticlopidin (bruges efter slagtilfælde), visse typer blodtrykssænkende medicin (bosentan) samt terbinafin (medicin mod svamp på tæer og negle).
English: If any of the above applies to you (or you are not sure), tell your doctor before taking Sandimmun.
Danish: Hvis noget af det ovenstående gælder for dig (eller hvis du er i tvivl), skal du fortælle det til din læge, inden du tager Sandimmun.
English: Ciclosporin is also an inhibitor of CYP3A4, the multidrug efflux transporter P-glycoprotein and organic anion transporter proteins (OATP) and may increase plasma levels of co-medications that are substrates of this enzyme and/or transporters.
Danish: Ciclosporin hæmmer også CYP3A4, multilægemiddel-effluks-transporteren P-glykoprotein og organisk aniontransporter-proteiner (OATP) og kan øge plasmaniveauet af samtidigt administrerede lægemidler, der er substrater for dette enzym og/eller transporter.
English: About 37% increase in AUC Cmax was observed when Sandimmun was administered with high-fat meal.
Danish: Når Sandimmun blev administreret sammen med et fedtholdigt måltid, faldt AUC Cmax med omkring 37%.
English: Other adverse drug reactions from post-marketing experience There have been solicited and spontaneous reports of hepatotoxicity and liver injury including cholestasis, jaundice hepatitis and liver failure in patients treated with ciclosporin.
Danish: Der har været velunderbyggede og spontant rapporterede tilfælde af hepatotoksicitet og leverskade, inklusive kolestase, gulsot, hepatitis og leversvigt hos patienter behandlet med ciclosporin.
English: The daily doses of Sandimmun should be given in two divided doses equally distributed throughout the day.
Danish: Den daglige dosis Sandimmun skal fordeles på to doser, der gives med ca. 12 timers interval.
English: If you take more Sandimmun than you should
Danish: Hvis du har taget for meget Sandimmun
English: Each capsule contains 50 mg ciclosporin.
Danish: Hver kapsel indeholder 50 mg ciclosporin.
English: • if you have gout.
Danish: • hvis du ammer.
English: What Sandimmun is used for and how Sandimmun works
Danish: Sådan anvendes og virker Sandimmun
English: - with products containing Hypericum perforatum (St John´s Wort).
Danish: - sammen med naturlægemidler, der indeholder Hypericum perforatum (perikon).
English: Discontinuation of Sandimmun is recommended if hypertension developing during treatment cannot be controlled with appropriate therapy.
Danish: Sandimmun skal seponeres, hvis hypertension, der opstår under behandlingen ikke kan kontrolleres med passende behandling.
English: In psoriatic patients on ciclosporin, as in those on conventional immunosuppressive therapy, development of malignancies (in particular of the skin) has been reported.
Danish: Der er rapporteret udvikling af maligniteter (især i huden) hos psoriasispatienter i behandling med ciclosporin såvel som hos psoriasispatienter i behandling med konventionelle immunsuppressiva.
English: Special excipients: Polyoxyl 40 hydrogenated castor oil Sandimmun contains polyoxyl 40 hydrogenated castor oil, which may cause stomach upsets and diarrhoea.
Danish: Særlige hjælpestoffer: Polyoxyleret, hydrogeneret ricinusolie Sandimmun indeholder polyoxyleret, hydrogeneret ricinusolie, som kan medføre svære allergiske reaktioner ved parenteral indgift.
English: Common side effects: These side effects may affect between 1 and 10 in every 100 people.
Danish: Almindelige bivirkninger: Disse bivirkninger kan forekomme hos mellem 1 og 10 ud af 100 personer.
English: No impairment in fertility was demonstrated in studies in male and female rats.
Danish: I studier er der ikke demonstreret nedsat fertilitet hos han- og hunrotter.
English: Detailed information on this medicinal product is available on the website of {name of MS/Agency}.
Danish: Yderligere oplysninger om dette lægemiddel findes på Sundhedsstyrelsens hjemmeside www.laegemiddelstyrelsen.dk.
English: with products containing Hypericum perforatum (St John´s Wort).
Danish: sammen med naturlægemidler, der indeholder Hypericum perforatum (perikon).
English: Migraine
Danish: mavesår
English: Ciclosporin is an inhibitor of CYP3A4, the multidrug efflux transporter P-glycoprotein and organic anion transporter proteins (OATP) and may increase plasma levels of co-medications that are substrates of this enzyme and/or transporter.
Danish: Ciclosporin hæmmer CYP3A4, multilægemiddel-effluks-transporteren P-glykoprotein og organisk aniontransporter-proteiner (OATP) og kan ved samtidig administration øge plasmakoncentrationen af lægemidler, som er substrater for dette enzym og/eller transporter.
English: Excessive growth of body and facial hair.
Danish: • Kraftig hårvækst på kropen og i ansigtet.