FrancophonIA/ELRC3.0 huggingface dataset:
English: Do not stop taking Darunavir Krkawithout talking to your doctor first Anti-HIVmedicinesmaymake you feel better.
Danish: Du må ikke stoppe med at tage Darunavir Krka uden først at tale med din læge Lægemidler til behandling af hiv-behandling kan få dig til at føle dig bedre.
English: silica, colloidal anhydrous; silicifiedmicrocrystallinecellulose (cellulose,microcrystalline;,
Danish: Silicificeret mikrokrystallinsk cellulose (Mikrokrystallinsk cellulose; Silica, kolloid vandfri)
English: Studies have been performed at lower than recommended doses of darunavir or with a different dosing regimen (see section 4.2 Posology).
Danish: Der er gennemført studier med doser af darunavir, der var lavere end den anbefalede dosis, eller med et andet doseringsregime (se pkt.
English: Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of these compounds and consequently that of darunavir, leading to loss of therapeutic effect and possible development of resistance (see sections 4.3 and 4.4).
Danish: Lægemidler, som inducerer CYP3A-aktivitet, må forventes at øge clearance af darunavir og ritonavir, hvilket ville forårsage reducerede plasmakoncentrationer af disse stoffer og dermed af darunavir, med efterfølgende tab af terapeutisk effekt og mulig resistensudvikling (se pkt.
English: ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17%
Danish: ANTIBIOTIKA Clarithromycin 500 mg to gange daglig clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17%
English: Skin and subcutaneous tissue disorders very common rash (including macular, maculopapular, papular, erythematous, pruritic rash, generalised rash, and allergic dermatitis)
Danish: Hud og subkutane væv meget almindelig udslæt (herunder makulært, makulopapulært, papulært, erytematøst, pruritisk udslæt, generaliseret udslæt og allergisk dermatitis)
English: 300 mg once daily atazanavir AUC ↔ atazanavir Cmin ↑ 52% atazanavir Cmax ↓ 11% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
Danish: 300 mg en gang daglig atazanavir AUC ↔ atazanavir Cmin ↑ 52% atazanavir Cmax ↓ 11% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
English: It is recommended that the international normalised ratio (INR) be monitored when warfarin is combined with darunavir coadministered with low dose ritonavir.
Danish: Det anbefales at monitorere INR (International normaliseret ratio), når warfarin kombineres med darunavir administreret sammen med lavdosis ritonavir.
English: When administration of atorvastatin and darunavir co-administered with low dose ritonavir is desired, it is recommended to start with an atorvastatin dose of 10 mg once daily.
Danish: Hvis der er behov for administration af atorvastatin og darunavir administreret sammen med lavdosis ritonavir, anbefales det at starte med en atorvastatindosis på 10 mg en gang daglig.
English: People taking Darunavir Krka may develop a skin rash.
Danish: Personer, der tager Darunavir Krka, kan udvikle hududslæt.
English: Concomitant administration of darunavir with low dose ritonavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity.
Danish: Samtidig administration af darunavir med lavdosis ritonavir og quetiapin er kontraindiceret, da quetiapin-relateret toksicitet derved kan øges.
English: A safe and effective dose of sildenafil for the treatment of pulmonary arterial hypertension co-administered with boosted darunavir has not been established.
Danish: En sikker og effektiv dosis af sildenafil til behandling af pulmonal arteriel hypertension administreret sammen med boostet darunavir er ikke fastlagt.
English: In deciding to initiate treatment with darunavir in such ART-experienced patients, genotypic testing should guide the use of darunavir (see sections 4.2, 4.3, 4.4 and 5.1).
Danish: I forbindelse med beslutningen om at påbegynde behandling med darunavir hos sådanne ART-erfarne patienter bør brugen af darunavir vejledes af genotypebestemmelse (se pkt.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with boosted darunavir is not recommended.
Danish: Co-administration af tadalafil til behandling af pulmonal arteriel hypertension og boostet darunavir anbefales ikke.
English: Methadone individual dose ranging from 55 mg to 150 mg once daily
Danish: NARKOTISKE ANALGETIKA / BEHANDLING AF OPIOIDAFHÆNGIGHED Metadon individuel dosering fra 55 mg-150 mg en gang daglig
English: If there is evidence of new or worsening liver dysfunction (including clinically significant elevation of liver enzymes and/or symptoms such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) in patients using darunavir/ritonavir, interruption or discontinuation of treatment should be considered promptly.
Danish: Ved nye tilfælde eller forværring af leverdysfunktion (med klinisk signifikant forhøjelse af leverenzymer og/eller symptomer såsom træthed, anoreksi, kvalme, gulsot, mørkfarvning af urin, ømhed over leveren, hepatomegali) hos patienter, der anvender darunavir/ritonavir, bør det overvejes omgående at seponere behandlingen eller indstille den midlertidigt.
English: Imputations according to the TLOVR algorithm.
Danish: I henhold til TLOVR-algoritmen
English: Dose for adults who have taken antiretroviral medicines before (your doctor will determine this) The dose is either: 600 milligram Darunavir Krka (1 tablet containing 600 milligram of Darunavir Krka) together with 100 milligram ritonavir twice daily.
Danish: Dosis til voksne, som tidligere har fået hiv-medicin (din læge vil afgøre dette) Dosis er enten: - 600 mg Darunavir Krka (1 tablet a 600 mg Darunavir Krka) sammen med 100 mg ritonavir to gange dagligt to gange dagligt.
English: Nervous system disorders common headache, peripheral neuropathy, dizziness uncommon lethargy, paraesthesia, hypoaesthesia, dysgeusia, disturbance in attention, memory impairment, somnolence rare syncope, convulsion, ageusia, sleep phase rhythm disturbance
Danish: Nervesystemet almindelig hovedpine, perifer neuropati, svimmelhed ikke almindelig letargi, paræstesi, hypæstesi, dysgeusi, opmærksomhedsforstyrrelser, hukommelsestab, somnolens sjælden synkope, krampe, ageusi, forstyrrelser i søvnfaserytmen
English: The recommended dose of emtricitabine/tenofovir alafenamide is 200/10 mg once daily when used with boosted darunavir.
Danish: Den anbefalede dosis emtricitabin/tenofoviralafenamid er 200/10 mg x 1, når det anvendes med boostet darunavir.
English: If there is evidence of new or worsening liver dysfunction (including clinically significant elevation of liver enzymes and/or symptoms such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) in patients using darunavir used in combination with cobicistat or low dose ritonavir, interruption or discontinuation of treatment should be considered promptly.
Danish: Ved nye tilfælde eller forværring af leverdysfunktion (med klinisk signifikant forhøjelse af leverenzymer og/eller symptomer såsom træthed, anoreksi, kvalme, gulsot, mørkfarvning af urin, ømhed over leveren, hepatomegali) hos patienter, der anvender darunavir i kombination med cobicistat eller lavdosis ritonavir, bør det omgående overveat seponere behandlingen eller indstille den midlertidigt.
English: If concomitant use of darunavir coadministered with low dose ritonavir with sildenafil, vardenafil or tadalafil is indicated, sildenafil at a single dose not exceeding 25 mg in 48 hours, vardenafil at a single dose not exceeding 2.5 mg in 72 hours or tadalafil at a single dose not exceeding 10 mg in 72 hours is recommended.
Danish: Hvis samtidig brug af sildenafil, vardenafil eller tadalafil og darunavir administreret sammen med lavdosis ritonavir er indiceret, anbefales det at give en enkeltdosis sildenafil på højst 25 mg i løbet af 48 timer, en enkeltdosis vardenafil på højst 2,5 mg i løbet af 72 timer eller en enkeltdosis tadalafil på højst 10 mg i løbet af 72 timer.
English: ART-experienced paediatric patients (3 to 17 years of age and weighing at least 15 kg) Darunavir twice daily taken with ritonavir taken with food is usually recommended.
Danish: ART-erfarne pædiatriske patienter (3 til 17 år og legemsvægt på mindst 15 kg) Det anbefales sædvanligvis at tage darunavir to gange dagligt med ritonavir i forbindelse med et måltid.
English: HIV Protease inhibitors (PIs) - without additional co-administration of low dose ritonavir Atazanavir
Danish: HIV-proteasehæmmere (PI) - uden yderligere co-administration af lavdosis ritonavir Atazanavir
English: The pharmacokinetic properties of darunavir, co-administered with cobicistat or ritonavir, have been evaluated in healthy adult volunteers and in HIV-1 infected patients.
Danish: De farmakokinetiske egenskaber af darunavir, co-administreret med cobicistat eller ritonavir, er blevet vurderet hos raske, voksne, frivillige forsøgspersoner og hos hiv-Iinficerede patienter.
English: This dose must not exceed the recommended adult dose, which is 600 milligram Darunavir Krka together with 100 milligram of ritonavir two times per day or 800 milligram Darunavir Krka together with 100 milligram ritonavir once a day.
Danish: Dosis må ikke overstige den anbefalede dosis til voksne, som er 600 mg Darunavir Krka sammen med 100 mg ritonavir to gang dagligt eller 800 mg Darunavir Krka sammen med 100 mg ritonavir en gang dagligt.
English: What Darunavir Krka contains - The active substance is darunavir.
Danish: Darunavir Krka indeholder - Aktivt stof: darunavir.
English: See the Summary of Product Characteristics for Darunavir Krka 600 mg tablets.
Danish: Se produktresuméet for Darunavir Krka 600 mg tabletter.
English: It is not recommended to co-administer boosted darunavir with glecaprevir/pibrentasvir.
Danish: Det frarådes at co-administrere boostet darunavir og glecaprevir/pibrentasvir.
English: Concomitant use of darunavir coadministered wirth low dose ritonavir and these antidepressants may increase concentrations of the antidepressant.
Danish: Samtidig brug af darunavir coadministreret med lavdosis ritonavir og disse antidepressiva kan øge koncentrationerne af antidepressivummet.
English: Co-administration of boosted darunavir and amiodarone, bepridil, dronedarone, ivabradine, quinidine, or ranolazine is contraindicated (see section 4.3).
Danish: Co-administration af boostet darunavir og amiodaron, bepridil, dronedaron, ivabradin, kinidin eller ranolazin er kontraindiceret (se pkt.
English: Darunavir co-administered with cobicistat lowers the creatinine clearance.
Danish: Darunavir co-administreret med cobicistat reducerer kreatininclearance.
English: Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with darunavir and low dose ritonavir is not recommended.
Danish: Co-administration af tadalafil til behandling af pulmonal arteriel hypertension, darunavir og lavdosis ritonavir anbefales ikke.
English: Lopinavir/ritonavir 400/100 mg twice daily
Danish: Lopinavir/ritonavir 400/100 mg to gange daglig
English: Clinical monitoring is recommended when co-administering boosted darunavir with these antidepressants and a dose adjustment of the antidepressant may be needed.
Danish: Klinisk monitorering anbefales ved co-administration af boostet darunavir med disse antidepressiva, og det kan være nødvendigt at justere dosis af antidepressivummet.
English: Hepatobiliary disorders common increased alanine aminotransferase uncommon hepatitis, cytolytic hepatitis, hepatic steatosis, hepatomegaly, increased transaminase, increased aspartate aminotransferase, increased blood bilirubin, increased blood alkaline phosphatase, increased gamma-glutamyltransferase
Danish: Lever og galdeveje almindelig forhøjet alanin-aminotranferase ikke almindelig hepatitis, cytolytisk hepatitis, hepatisk steatose, hepatomegali, forhøjet aminotransferase, forhøjet aspartat-aminotranferase, forhøjet bilirubin i blodet, forhøjet alkalisk phosphatase i blodet, forhøjet gamma-glutamyltransferase
English: Warfarin concentrations may be affected when co-administered with boosted darunavir.
Danish: Warfarinkoncentrationer kan blive påvirket ved samtidig administration af boostet darunavir.
English: The child must take Darunavir Krka always together with ritonavir.
Danish: Anvisninger for børn - Barnet skal altid tage Darunavir Krka sammen med ritonavir.
English: Darunavir Krka with ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Danish: Darunavir Krka med ritonavir er ikke blevet testet med alle proteasehæmmere og må ikke bruges med andre hiv-proteasehæmmere.
English: BOX
Danish: ÆSKE
English: Exposure to these immunosuppressants will be increased when co-administered with darunavir coadministered with low dose ritonavir.
Danish: Eksponeringen for disse immunsuppressiva vil øges ved samtidig administration af darunavir co-administreret med lavdosis ritonavir.
English: Darunavir Krka, co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection (see section 4.2).
Danish: Darunavir Krka, administreret sammen med lavdosis ritonavir, er i kombination med andre antiretrovirale lægemidler indiceret til behandling af patienter med human immundefektvirus (hiv-1)-infektion (se pkt.
English: The interaction profile of darunavir depends on whether ritonavir is used as pharmacokinetic enhancer.
Danish: Interaktionsprofilen for darunavir er afhængig af, om ritonavir benyttes som farmakokinetisk forstærker.
English: Darunavir is primarily metabolised by CYP3A.
Danish: Darunavir metaboliseres især via CYP3A.
English: Medicinal products that affect darunavir exposure (cobicistat as pharmacoenhancer)
Danish: Lægemidler, som påvirker darunavireksponering (cobicistat som farmakoforstærker)
English: It is not recommended to coadminister boosted darunavir and boceprevir.
Danish: Det anbefales ikke at coadministrere boostet darunavir og boceprevir.
English: No adjustment of methadone dosage is required when initiating coadministration with darunavir /ritonavir.
Danish: Det er ikke nødvendigt at justere metadondosis, når der påbegyndes behandling med darunavir/ritonavir.
English: Tenofovir disoproxil 245 mg once daily tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% darunavir AUC ↑ 21% darunavir Cmin ↑ 24% darunavir Cmax ↑ 16% (↑ tenofovir from effect on MDR-1 transport in the renal tubules)
Danish: Tenofovirdisoproxil 245 mg en gang daglig tenofovir AUC ↑ 22% tenofovir Cmin ↑ 37% tenofovir Cmax ↑ 24% darunavir AUC ↑ 21% darunavir Cmin ↑ 24% darunavir Cmax ↑ 16% (↑ tenofovir fra effekten på MDR-1 transport i de renale tubuli)
English: After therapy has been initiated, the dose or dosage form must not be changed or therapy must not be stopped without instruction of the doctor.
Danish: Efter behandlingen er påbegyndt, må du ikke ændre dosis eller lægemiddelform eller afbryde behandlingen uden først at tale med lægen.
English: Caution should be exercised when clarithromycin is combined with boosted darunavir.
Danish: Der skal udvises forsigtighed, når clarithromycin kombineres med boostet darunavir.
English: Warfarin concentrations may be affected when co-administered with darunavir with low dose ritonavir.
Danish: Warfarinkoncentrationer kan blive påvirket ved samtidig administration af darunavir med lavdosis ritonavir.
English: Amitriptyline Desipramine Imipramine Nortriptyline Trazodone paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
Danish: Sertralin 50 mg en gang daglig paroxetin AUC ↓ 39% paroxetin Cmin ↓ 37% paroxetin Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49% sertralin Cmin ↓ 49% sertralin Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
English: In the 96 week analysis, the safety profile of darunavir/ritonavir 800/100 mg once daily in treatmentnaïve subjects was similar to that seen with darunavir/ritonavir 600/100 mg twice daily in treatmentexperienced subjects except for nausea which was observed more frequently in treatment-naïve subjects.
Danish: I 96-ugers-analysen svarede sikkerhedsprofilen for darunavir/ritonavir 800/100 mg en gang daglig hos behandlingsnaive patienter til profilen for darunavir/ritonavir 600/100 mg to gange daglig hos behandllingserfarne patienter med undtagelse af kvalme, der sås hyppigere hos behandlingsnaive patienter.
English: In the virologic failures of the ARTEMIS trial no cross-resistance with other PIs was observed.
Danish: Der blev ikke observeret nogen krydsresistens med andre PI i de virologiske svigt fra ARTEMIS-studiet.
English: Caution is warranted and therapeutic concentration monitoring, if available, is recommended for these antiarrhythmics when coadministered with boosted darunavir.
Danish: Der skal udvises forsigtighed, og om muligt anbefales monitorering af terapeutisk koncentration for disse antiarytmika ved coadministration med boostet darunavir.
English: Clinical monitoring for central nervous system toxicity associated with increased exposure to efavirenz may be indicated when darunavir coadministered with low dose ritonavir is given in combination with efavirenz.
Danish: Klinisk monitorering for centralnervesystemstoksicitet i forbindelse med øget eksponering for efavirenz kan være indiceret, når darunavir administreres sammen med lavdosis ritonavir gives i kombination med efavirenz.
English: Darunavir/ritonavir should be used during pregnancy only if the potential benefit justifies the potential risk.
Danish: Darunavir/ritonavir bør kun anvendes under graviditet, hvis den mulige fordel opvejer den mulige risiko.
English: Reproductive system and breast disorders uncommon gynaecomastia*
Danish: Det reproduktive system og mammae ikke almindelig gynækomasti*
English: Co-administration of darunavir coadministered with cobicistat and rifabutin is not recommended.
Danish: Co-administration af darunavir co-administreret med cobicistat og rifabutin frarådes.
English: ART-experienced paediatric patients (3 to 17 years of age and weighing at least 40 kg)
Danish: ART-erfarne pædiatriske patienter i alderen 6 til <18 år og legemsvægt på mindst 20 kg
English: Systemic dexamethasone should be used with caution when combined with darunavir co-administered with low dose ritonavir.
Danish: Systemisk dexamethason skal bruges med forsigtighed ved kombination med darunavir administreret sammen med lavdosis ritonavir.
English: ANTICONVULSANTS Phenobarbital Phenytoin
Danish: ANTIEPILEPTIKA Phenobarbital Phenytoin
English: Plasma concentrations of these medicinal products may be increased when co-administered with boosted darunavir, resulting in reduced serum cortisol concentrations.
Danish: Plasmakoncentrationen af disse lægemidler kan øges ved samtidig administration af boostet darunavir, hvilket medfører nedsat serumcortisol.
English: Darunavir Krkamust be taken in combination with a low dose of ritonavir and other anti-HIV medicines.
Danish: Darunavir Krka skal tages i kombination med en lav dosis ritonavir og anden hivmedicin.
English: Rilpivirine 150 mg once daily rilpivirine AUC ↑ 130% rilpivirine Cmin ↑ 178% rilpivirine Cmax ↑ 79% darunavir AUC ↔ darunavir Cmin ↓ 11% darunavir Cmax ↔
Danish: Rilpivirin 150 mg en gang daglig rilpivirin AUC ↑ 130% rilpivirin Cmin ↑ 178% rilpivirin Cmax ↑ 79% darunavir AUC ↔ darunavir Cmin ↓ 11% darunavir Cmax ↔
English: If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Danish: Er du i tvivl, så spørg lægen apotekspersonalet eller sygeplejersken.
English: If parenteral midazolam is co-administered with darunavir co-administered with low dose ritonavir it may cause a large increase in the concentration of this benzodiazepine.
Danish: Co-administration af parenteral midazolam med darunavir coadministreret med lavdosis ritonavir kan give en kraftig forøgelse af koncentrationen af dette benzodiazepin.
English: Take Darunavir Krka always together with 100 milligram of ritonavir.
Danish: - Tag altid Darunavir Krka sammen med 100 mg ritonavir.
English: Saquinavir 1,000 mg twice daily darunavir AUC ↓ 26% darunavir Cmin ↓ 42% darunavir Cmax ↓ 17% saquinavir AUC ↓ 6% saquinavir Cmin ↓ 18% saquinavir Cmax ↓ 6%
Danish: Saquinavir 1.000 mg to gange daglig darunavir AUC ↓ 26% darunavir Cmin ↓ 42% darunavir Cmax ↓ 17% saquinavir AUC ↓ 6% saquinavir Cmin ↓ 18% saquinavir Cmax ↓ 6%
English: The dose is either:
Danish: Disse omfatter:
English: Plasma concentrations of these medicinal products may be increased when co-administered with darunavir with low dose ritonavir, resulting in reduced serum cortisol concentrations.
Danish: Plasmakoncentrationen af disse lægemidler kan øges ved samtidig administration af darunavir med lavdoisis ritonavir, hvilket medfører nedsat serumcortisol.
English: Darunavir Krka is available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a boxes.
Danish: Darunavir Krka er tilgængelig i beholdere indeholdende 30 filmovertrukne tabletter (1 beholder med 30 filmovertrukne tabletter), 60 filmovertrukne tabletter (2 beholdere med 30 filmovertrukne tabletter), 90 filmovertrukne tabletter (3 beholdere med 30 filmovertrukne tabletter) og 180 filmovertrukne tabletter (6 beholdere med 30 filmovertrukne tabletter) i en æske.
English: Darunavir co-administered with low dose ritonavir can be expected to increase the plasma concentrations of calcium channel blockers.
Danish: Darunavir coadministereret med lavdosis ritonavir kan forventes at øge plasmakoncentrationen af calciumantagonisterne.
English: Concomitant use of darunavir with low dose ritonavir and corticosteroids that are metabolised by CYP3A (e.g. fluticasone propionate or other inhaled or nasal corticosteroids) may increase the risk of development of systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression.
Danish: Samtidig brug af darunavir med lavdoisis ritonavir og kortikosteroider, der metaboliseres via CYP3A (f.eks. fluticasonpropionat eller andre inhalerede eller nasale kortikosteroider) kan øge risikoen for systemiske kortikosteroidbivirkninger, herunder Cushings syndrom og binyresuppression.
English: See the Summary of Product Characteristics for Darunavir Krka 600 mg tablets (see section 4.5).
Danish: Se Produktresuméet for Darunavir Krka 600 mg tabletter (se pkt.
English: For dosage recommendations in ART-naïve patients see the Summary of Product Characteristics for Darunavir Krka 400 mg and 800 mg tablets.
Danish: Se doseringsanbefalingerne til ART-naive patienter se produktresuméet for Darunavir Krka 400 mg og 800 mg tabletter.
English: Although the effect on CYP2C8 has only been studied in vitro, co-administration of darunavir and ritonavir and medicinal products primarily metabolised by CYP2C8 (such as paclitaxel, rosiglitazone, repaglinide) may result in decreased systemic exposure to such medicinal products, which could decrease or shorten their therapeutic effect.
Danish: Selvom effekten på CYP2C8 kun er blevet undersøgt in vitro, kan co-administration af darunavir og ritonavir og lægemidler, som primært metaboliseres af CYP2C8 (såsom paclitaxel, rosiglitazon, repaglinid), resultere i nedsat systemisk eksponering af disse lægemidler, hvilken kan nedsætte eller forkorte deres terapeutiske effekt.
English: Darunavir must always be given orally with low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products.
Danish: Darunavir skal altid gives oralt med lavdosis ritonavir som en farmakokinetisk forstærker og i kombination med andre antiretrovirale lægemidler.
English: Postpartum (6-12 weeks) (n=6)
Danish: Postpartum (6-12 uger) (n = 6)