FrancophonIA/ELRC3.0 huggingface dataset:
English: It is very important that you also read the leaflets for the other medicines that you will be taking with ZEPATIER.
Croatian: Vrlo je važno da pročitate i upute o lijeku za druge lijekove koje ćete uzimati s lijekom ZEPATIER.
English: • decide if you should take ZEPATIER and for how long
Croatian: • odlučiti trebate li uzimati ZEPATIER i koliko dugo
English: Hepatitis C is a virus that infects the liver.
Croatian: Virus hepatitisa C je virus koji napada jetru.
English: The recommended dose is one tablet once a day with or without food.
Croatian: Preporučena doza je jedna tableta jedanput na dan, s hranom ili bez nje.
English: ALT (IU/L) 5.1-10.0 × ULN
Croatian: ALT (IU/l) 5,1-10,0 × GGN
English: • you have certain moderate or severe liver problems
Croatian: • ako imate određene umjerene ili teške jetrene tegobe
English: See list under “Do not take ZEPATIER if you are taking any of the following medicines.”
Croatian: Pogledajte popis u dijelu "Nemojte uzimati ZEPATIER ako uzimate neki od sljedećih lijekova."
English: This includes herbal medicines and medicines obtained without a prescription.
Croatian: To uključuje biljne lijekove i druge lijekove koje ste nabavili bez recepta.
English: ZEPATIER is sometimes taken with another medicine, ribavirin.
Croatian: ZEPATIER se ponekad uzima zajedno s drugim lijekom, ribavirinom.
English: The film-coated tablets should be swallowed whole and may be taken with or without food (see section 5.2).
Croatian: Filmom obložene tablete treba progutati cijele, a mogu se uzeti s hranom ili bez nje (vidjeti dio 5.2).
English: Frequencies are defined as follows: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000) or very rare (< 1/10,000).
Croatian: Učestalost pojavljivanja definirana je kao: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000) ili vrlo rijetko (<1/10 000).
English: The active substances in the medicine work together by blocking two different proteins that the hepatitis C virus needs to grow and reproduce.
Croatian: Djelatne tvari u lijeku djeluju zajedno tako što blokiraju dva različita proteina koja su virusu hepatitisa C potrebna za rast i umnožavanje.
English: Table 2 provides a listing of assessed or potential medicinal product interactions.
Croatian: Tablica 2 prikazuje popis utvrđenih ili potencijalnih interakcija između lijekova.
English: If you are pregnant, think you might be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Croatian: Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku za savjet prije nego uzmete ovaj lijek.
English: If you do miss a dose, work out how long it is since you should have taken ZEPATIER:
Croatian: Ako ipak propustite dozu, izračunajte koliko je vremena prošlo otkad ste trebali uzeti ZEPATIER:
English: Mean ratio (90 % confidence interval) for AUC, Cmax, C12 or C24 (likely mechanism of interaction)
Croatian: Omjer srednjih vrijednosti (90% interval pouzdanosti, CI) za AUC, Cmax, C12 ili C24 (vjerojatan mehanizam interakcije)
English: Aluminium or magnesium hydroxide; calcium carbonate
Croatian: Aluminijev ili magnezijev hidroksid; kalcijev karbonat
English: • rosuvastatin, atorvastatin, fluvastatin, simvastatin, or lovastatin, for lowering blood cholesterol
Croatian: • rosuvastatin, atorvastatin, fluvastatin, simvastatin ili lovastatin, za snižavanje razine kolesterola u krvi
English: The long-term clinical impact of the emergence or persistence of virus containing ZEPATIER resistance-associated substitutions is unknown.
Croatian: Dugoročan klinički utjecaj pojave ili postojanosti virusa koji sadrži supstitucije povezane s rezistencijom na ZEPATIER nije poznat.
English: Your doctor may have to change your medicines or change the dose of your medicines.
Croatian: Vaš će liječnik možda morati promijeniti lijekove koje uzimate ili prilagoditi njihovu dozu.
English: What ZEPATIER is and what it is used for
Croatian: Što je ZEPATIER i za što se koristi
English: Swallow the tablet whole with or without food.
Croatian: Tabletu progutajte cijelu, s hranom ili bez nje.
English: • you are allergic to elbasvir, grazoprevir or any of the other ingredients of this medicine (listed in section 6)
Croatian: • ako ste alergični na elbasvir, grazoprevir ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: If you take more ZEPATIER than you should, talk to a doctor straight away.
Croatian: Ako uzmete više lijeka ZEPATIER nego što ste trebali, odmah se obratite liječniku.
English: What ZEPATIER is and what it is used for What you need to know before you take ZEPATIER How to take ZEPATIER
Croatian: Što je ZEPATIER i za što se koristi Što morate znati prije nego počnete uzimati ZEPATIER Kako uzimati ZEPATIER
English: • decide what other medicines you should take with ZEPATIER and for how long
Croatian: • odlučiti koje druge lijekove trebate uzimati s lijekom ZEPATIER i koliko dugo
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from ZEPATIER therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Croatian: Mora se donijeti odluka o tome hoće li se prekinuti dojenje ili prekinuti/privremeno odgoditi liječenje lijekom ZEPATIER uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
English: If you take more ZEPATIER than you should
Croatian: Ako uzmete više lijeka ZEPATIER nego što ste trebali
English: The effects of ZEPATIER in pregnancy are not known.
Croatian: Učinci lijeka ZEPATIER na trudnoću nisu poznati.
English: GT4 (treatmentexperienced)
Croatian: GT4 (prethodno liječeni)
English: In order to evaluate the recurrence of hepatocellular carcinoma associated with Zepatier the MAH shall conduct and submit the results of a prospective safety study using data deriving from a cohort of a well-defined group of patients, based on an agreed protocol.
Croatian: Kako bi se procijenilo ponovno pojavljivanje hepatocelularnog karcinoma povezanog s primjenom lijeka Zepatier, nositelj odobrenja mora provesti i dostaviti rezultate prospektivnog ispitivanja sigurnosti, koristeći podatake koji proizlaze iz kohorte dobro definirane skupine bolesnika, na temelju dogovorenog protokola.
English: In clinical studies, the most commonly reported adverse reactions (greater than 10%) were fatigue and headache.
Croatian: U kliničkim su ispitivanjima najčešće prijavljivane nuspojave (više od 10%) bile umor i glavobolja.
English: Do not take ZEPATIER if:
Croatian: Nemojte uzimati ZEPATIER:
English: Population pharmacokinetics estimates of exposure of elbasvir and grazoprevir were comparable between Whites and Black/African Americans.
Croatian: Populacijske farmakokinetičke procjene izloženosti elbasviru i grazopreviru bile su usporedive između bijelaca i crnaca/Afroamerikanaca.
English: ZEPATIER (administered alone or in combination with ribavirin) is not likely to have an effect on the ability to drive and use machines.
Croatian: Nije vjerojatno da će ZEPATIER (primijenjen samostalno ili u kombinaciji s ribavirinom) imati učinak na sposobnost upravljanja vozilima i rada sa strojevima.
English: Patients should be instructed that if vomiting occurs within 4 hours of dosing, an additional tablet can be taken up to 8 hours before the next dose.
Croatian: Bolesnike treba uputiti da ako se povraćanje javi unutar 4 sata od primjene doze mogu uzeti dodatnu tabletu do 8 sati prije sljedeće doze.
English: BLISTER GLUED WITHIN THE INNER WALLET
Croatian: BLISTER ZALIJEPLJEN UNUTAR UNUTARNJEG KARTONSKOG OVITKA
English: Includes 1 subject with cirrhosis status of “unknown” in C-SCAPE.
Croatian: Uključuje 1 ispitanika sa statusom ciroze "nepoznato" u ispitivanju C-SCAPE.
English: • check if your treatment has worked and you are free of hepatitis C
Croatian: • provjeriti je li liječenje djelotvorno i jeste li se izliječili od hepatitisa C
English: Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
Croatian: Čuvajte popis svih lijekova koje uzimate i pokažite ga svom liječniku ili ljekarniku kad dobijete novi lijek.
English: Each carton contains a total of 28 tablets.
Croatian: Jedna kutija sadrži ukupno 28 tableta.
English: What you need to know before you take ZEPATIER
Croatian: Što morate znati prije nego počnete uzimati ZEPATIER
English: For elbasvir, the absolute bioavailability is estimated to be 32%.
Croatian: Procijenjena apsolutna bioraspoloživost elbasvira je 32%.
English: • have ever taken any medicine for hepatitis C
Croatian: • ako ste ikada uzimali bilo koji lijek za liječenje hepatitisa C
English: ZEPATIER with ribavirin
Croatian: ZEPATIER s ribavirinom
English: ZEPATIER + RBV, 16 Weeks
Croatian: ZEPATIER + RBV, 16 tjedana
English: Your doctor will test your blood before, during and after your treatment with ZEPATIER.
Croatian: Liječnik će napraviti krvne pretrage prije, tijekom i nakon liječenja lijekom ZEPATIER.
English: • trouble sleeping (insomnia)
Croatian: • tegobe sa spavanjem (nesanica)
English: • feeling weak or lack of energy (asthenia)
Croatian: • slabost ili nedostatak energije (astenija)
English: This means you and your partner must take special precautions in sexual activity if there is any chance you or your partner could become pregnant.
Croatian: To znači da Vi ili Vaš(a) partner(ica) morate poduzeti posebne mjere opreza pri spolnom odnosu ako postoji ikakva mogućnost za trudnoću.
English: In these healthy volunteer studies, adverse reactions were similar in frequency and severity to those reported in the placebo groups.
Croatian: U tim ispitivanjima na zdravim dobrovoljcima učestalost i težina nuspojava bile su slične onima prijavljenima u skupinama koje su primale placebo.
English: The efficacy of ZEPATIER has not been demonstrated in HCV genotypes 2, 3, 5 and 6.
Croatian: Djelotvornost lijeka ZEPATIER nije dokazana u bolesnika s HCV-om genotipa 2, 3, 5 i 6.
English: There are no adequate and well-controlled studies with ZEPATIER in pregnant women.
Croatian: Nisu provedena odgovarajuća i dobro kontrolirana ispitivanja lijeka ZEPATIER u trudnica.
English: Other medicines and ZEPATIER
Croatian: Drugi lijekovi i ZEPATIER
English: Because reproduction animal studies are not always predictive of human response, ZEPATIER should be used only if the potential benefit justifies the potential risk to the fetus.
Croatian: Budući da se iz ispitivanja reprodukcije na životinjama ne može uvijek predvidjeti odgovor u ljudi, ZEPATIER se tijekom trudnoće smije primjenjivati samo ako moguća korist za majku opravdava mogući rizik za plod.
English: These late ALT elevations were typically asymptomatic.
Croatian: Ta kasna povišenja vrijednosti ALT-a obično su bila asimptomatska.
English: When ZEPATIER is used in combination with ribavirin, women of childbearing potential or their male partners must use an effective form of contraception during treatment and for a period of time after the treatment has concluded.
Croatian: Kada se ZEPATIER primjenjuje u kombinaciji s ribavirinom, žene reproduktivne dobi ili njihovi partneri muškog spola moraju koristiti učinkovit oblik kontracepcije tijekom liječenja i još neko vrijeme nakon završetka liječenja.
English: • have any liver problems other than hepatitis C
Croatian: • ako imate i bilo koje druge jetrene tegobe osim hepatitisa C
English: Psychiatric disorders: Common insomnia, anxiety, depression
Croatian: Psihijatrijski poremećaji: često nesanica, tjeskoba, depresija
English: Uncommon: may affect up to 1 in 100 people • abnormalities in laboratory tests of liver function
Croatian: Manje česte: mogu se javiti u do 1 na 100 osoba • odstupanja u nalazima laboratorijskih pretraga funkcije jetre
English: Elbasvir pharmacokinetics are similar in healthy subjects and HCV-infected subjects.
Croatian: Farmakokinetika elbasvira slična je u zdravih ispitanika i onih zaraženih HCV-om.
English: These late ALT elevations generally occurred at or after treatment week 8.
Croatian: Ta kasna povišenja ALT-a obično su nastupila u 8. tjednu liječenja ili nakon njega.
English: If vomiting occurs more than 4 hours after dosing, no further dose is needed.
Croatian: Ako se povraćanje javi više od 4 sata od primjene doze, nije potrebna dodatna doza.
English: • tacrolimus to prevent organ transplant rejection
Croatian: • takrolimus, za sprječavanje odbacivanja presađenog organa
English: Do not use the medicine after the expiry date which is stated on the carton and blister packaging after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blister pakiranju iza oznake "EXP".
English: What ZEPATIER contains
Croatian: Što ZEPATIER sadrži
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicinal product.
Croatian: Bolesnici s rijetkim nasljednim poremećajima nepodnošenja galaktoze, nedostatkom Lapp laktaze ili malapsorpcijom glukoze i galaktoze ne smiju uzimati ovaj lijek.
English: Pharmacotherapeutic group: Antivirals for systemic use, Direct acting antivirals, Antivirals for treatment of HCV infections, ATC code: J05AP54.
Croatian: Farmakoterapijska skupina: Antivirotici za sistemsku primjenu, Antivirotici koji djeluju direktno, Antivirotici za liječenje HCV infekcija, ATK oznaka: J05AP54.
English: • have diabetes.
Croatian: • imate šećernu bolest.
English: ZEPATIER is not recommended in patients infected with these genotypes.
Croatian: Ne preporučuje se primjena lijeka ZEPATIER u bolesnika zaraženih tim genotipovima.
English: An up “↑” or down “↓” arrow represents a change in exposure that requires monitoring or a dose adjustment of that medication, or the co-administration is not recommended or contraindicated.
Croatian: Strelica usmjerena prema gore ("↑") ili dolje ("↓") predstavlja promjenu izloženosti koja zahtijeva praćenje ili prilagodbu doze tog lijeka ili znači da se istodobna primjena ne preporučuje ili je kontraindicirana.
English: If you forget to take ZEPATIER
Croatian: Ako ste zaboravili uzeti ZEPATIER
English: Median EC50 (range) nM
Croatian: Medijan EC50 (raspon) nM
English: For patients receiving 16 weeks of therapy, additional hepatic laboratory testing should be performed at treatment week 12.
Croatian: U bolesnika koji primaju terapiju tijekom 16 tjedana potrebno je provesti i dodatne laboratorijske pretrage funkcije jetre u 12. tjednu liječenja.
English: ZEPATIER is not recommended for use in children and adolescents under 18 years of age because the safety and efficacy have not been established in this population.
Croatian: Primjena lijeka ZEPATIER ne preporučuje se u djece i adolescenata mlađih od 18 godina jer sigurnost i djelotvornost u toj populaciji nisu ustanovljene.
English: In case of overdose, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions and appropriate symptomatic treatment instituted.
Croatian: U slučaju predoziranja preporučuje se nadzirati bolesnika zbog moguće pojave znakova ili simptoma nuspojava te uvesti odgovarajuće simptomatsko liječenje.
English: Table 8: Studies conducted with ZEPATIER
Croatian: Tablica 8: Ispitivanja provedena s lijekom ZEPATIER
English: Includes four subjects infected with genotype 1 subtypes other than 1a or 1b.
Croatian: Uključuje četiri ispitanika s infekcijom virusom genotipa 1 podtipa koji nije 1a ili 1b.
English: Table 2: Interactions and dose recommendations with other medicinal products
Croatian: Tablica 2: Interakcije i preporuke za doziranje kod primjene s drugim lijekovima
English: The European Medicines Agency has deferred the obligation to submit the results of studies with ZEPATIER in one or more subsets of the paediatric populations in the treatment of chronic hepatitis C (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja lijeka ZEPATIER u jednoj ili više podskupina pedijatrijske populacije za liječenje kroničnog hepatitisa C (vidjeti dio 4.2 za informacije o primjeni u pedijatrijskoj populaciji).
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, and toxicity to reproduction and development with grazoprevir or elbasvir.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti te reproduktivne i razvojne toksičnosti grazoprevira ili elbasvira.
English: Q2 2023
Croatian: drugo tromjesječje 2023. godine
English: These differences in elbasvir and grazoprevir exposure are not clinically relevant; therefore, elbasvir/grazoprevir may be taken without regard to food.
Croatian: Te razlike u izloženosti elbasviru i grazopreviru nisu klinički značajne; stoga se elbasvir/grazoprevir može uzimati neovisno o hrani.
English: There are some medicines you must not take with ZEPATIER.
Croatian: Neki lijekovi se ne smiju uzimati s lijekom ZEPATIER.
English: What ZEPATIER is used for ZEPATIER is used to treat long-term hepatitis C infection in adults aged 18 years and older.
Croatian: ZEPATIER se koristi za liječenje dugotrajne infekcije virusom hepatitisa C u odraslih osoba u dobi od 18 godina i starijih.
English: • Discontinuation of ZEPATIER should be considered if ALT levels are confirmed to be greater than 10 times the ULN.
Croatian: • Treba razmotriti prekid liječenja lijekom ZEPATIER ako se potvrdi da su vrijednosti ALT-a više od 10 puta iznad GGN-a.
English: • If it has been less than 16 hours since you should have taken your dose, take the missed dose as soon as possible.
Croatian: • Ako je prošlo manje od 16 sati otkad ste trebali uzeti dozu, uzmite propuštenu dozu što je prije moguće.
English: Nervous system disorders: Very common headache
Croatian: Poremećaji živčanog sustava: vrlo često glavobolja često omaglica
English: The pharmacokinetics of elbasvir/grazoprevir in paediatric patients less than 18 years of age have not been established (see section 4.2).
Croatian: Farmakokinetika elbasvira/grazoprevira nije ustanovljena u pedijatrijskih bolesnika mlađih od 18 godina (vidjeti dio 4.2).
English: Elbasvir has minimal intestinal P-gp inhibition in humans, and does not result in clinically relevant increases in concentrations of digoxin (a P-gp substrate), with an 11% increase in plasma AUC.
Croatian: Elbasvir uzrokuje minimalnu inhibiciju P-gp-a u crijevima ljudi i ne uzrokuje klinički značajno povišenje koncentracije digoksina (supstrata P-gp-a), ali povećava AUC u plazmi za 11%.
English: Human experience of overdose with ZEPATIER is limited.
Croatian: Iskustvo s predoziranjem lijekom ZEPATIER u ljudi je ograničeno.
English: Less than 0.5 % of grazoprevir was recovered in dialysate over a 4-hour dialysis session.
Croatian: Manje od 0,5% grazoprevira pronađeno je u dijalizatu tijekom 4-satne dijalize.
English: Higher rates of late ALT elevations occurred in females (2 % [11/652]), Asians (2 % [4/165]), and subjects aged ≥ 65 years (2 % [3/187]) (see sections 4.8 and 5.2).
Croatian: Više stope kasnih povišenja vrijednosti ALT-a zabilježene su u žena (2% [11/652], Azijata (2% [4/165] i ispitanika u dobi od ≥65 godina (2% [3/187]) (vidjeti dijelove 4.8 i 5.2).
English: • You or your partner must use an effective method of contraception during treatment with ZEPATIER with ribavirin and for some time afterwards.
Croatian: • Vi ili Vaš(a) partner(ica) morate koristiti učinkovitu metodu kontracepcije tijekom liječenja lijekom ZEPATIER s ribavirinom i još neko vrijeme po završetku liječenja.
English: Recommended regimens and treatment durations are provided in Table 1 below (see sections 4.4 and 5.1):
Croatian: Preporučeni režimi i trajanje liječenja prikazani su u Tablici 1 u nastavku (vidjeti dijelove 4.4 i 5.1):
English: If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking ZEPATIER.
Croatian: Ako se bilo što od navedenoga odnosi na Vas (ili niste sigurni), razgovarajte sa svojim liječnikom ili ljekarnikom prije nego uzmete ZEPATIER.
English: The rate of late ALT elevations during treatment is directly related to the plasma exposure to grazoprevir.
Croatian: Stopa kasnih povišenja vrijednosti ALT-a tijekom liječenja izravno je povezana s izloženošću grazopreviru u plazmi.
English: Elbasvir and grazoprevir are partially eliminated by oxidative metabolism, primarily by CYP3A.
Croatian: Elbasvir i grazoprevir djelomično se eliminiraju oksidacijskim metabolizmom, prvenstveno putem CYP3A.
English: Based on in vitro data, clinically significant interactions with ZEPATIER as an inhibitor of other CYP enzymes, UGT1A1, esterases (CES1, CES2, and CatA), OAT1, OAT3, and OCT2 are not expected.
Croatian: Prema podacima in vitro, ne očekuju se klinički značajne interakcije s lijekom ZEPATIER kao inhibitorom drugih CYP enzima, UGT1A1, esteraza (CES1, CES2 i CatA), OAT1, OAT3 i OCT2.
English: Do not stop taking ZEPATIER
Croatian: Nemojte prestati uzimati ZEPATIER
English: In case a dose of ZEPATIER is missed and it is within 16 hours of the time ZEPATIER is usually taken, the patient should be instructed to take ZEPATIER as soon as possible and then take the next dose of ZEPATIER at the usual time.
Croatian: Ako bolesnik propusti uzeti dozu lijeka ZEPATIER unutar 16 sati od vremena kada obično uzima ZEPATIER, treba mu savjetovati da uzme ZEPATIER što je prije moguće i zatim uzme sljedeću dozu lijeka ZEPATIER u uobičajeno vrijeme.
English: • unusual hair loss or thinning
Croatian: • neubičajeno opadanje ili stanjivanje kose
English: ZEPATIER contains 3.04 mmol (or 69.85 mg) sodium per dose.
Croatian: ZEPATIER sadrži 3,04 mmol (ili 69,85 mg) natrija po dozi.
English: What ZEPATIER is ZEPATIER is an antiviral medicine that contains the active substances elbasvir and grazoprevir.
Croatian: Što je ZEPATIER ZEPATIER je antivirusni lijek koji sadrži djelatne tvari elbasvir i grazoprevir.
English: Talk to your doctor or pharmacist before taking ZEPATIER if you have ever taken any medicines for hepatitis C or if you have any other medical condition.
Croatian: Prije nego uzmete ZEPATIER, porazgovarajte sa svojim liječnikom ili ljekarnikom ako ste ikada uzimali lijekove za liječenje hepatitisa C ili ako imate i neku drugu bolest.
English: Available pharmacokinetic data in animals has shown excretion of elbasvir and grazoprevir in milk.
Croatian: Dostupni farmakokinetički podaci u životinja pokazuju da se elbasvir i grazoprevir izlučuju u mlijeko.
English: Interactions between ZEPATIER and other medicinal products
Croatian: Interakcije između lijeka ZEPATIER i drugih lijekova
English: If ZEPATIER is co-administered with ribavirin, the information for ribavirin with regard to contraception, pregnancy testing, pregnancy, breast-feeding, and fertility also applies to this combination regimen (refer to the Summary of Product Characteristics for the co-administered medicinal product for additional information).
Croatian: Ako se ZEPATIER primjenjuje istodobno s ribavirinom, informacije koje se odnose na kontracepciju, testiranje na trudnoću, trudnoću, dojenje i plodnost kod primjene ribavirina vrijede i za ovaj kombinirani režim liječenja (za dodatne informacije pročitajte sažetak opisa svojstava lijeka koji se istodobno primjenjuje).
English: ZEPATIER combines two direct-acting antiviral agents with distinct mechanisms of action and nonoverlapping resistance profiles to target HCV at multiple steps in the viral lifecycle.
Croatian: ZEPATIER je kombinacija dva direktno djelujuća antivirotika s različitim mehanizmima djelovanja i profilima rezistencije koji se međusobno ne preklapaju, što omogućuje ciljano djelovanje na HCV u više različitih stadija životnog ciklusa virusa.
English: • feeling nervous (anxiety)
Croatian: • nervoza (tjeskoba)