FrancophonIA/ELRC3.0 huggingface dataset:
English: If no liquid splashes out, the pen should not be used.
Croatian: Ako iz igle nije izašlo nimalo tekućine, nemojte upotrijebiti brizgalicu.
English: Lightly pinch the skin of the injection area.
Croatian: Laganim stiskom uhvatite nabor kože na mjestu injiciranja.
English: • Follitropin alfa in association with a luteinising hormone (LH) preparation is recommended for the stimulation of follicular development in women with severe LH and FSH deficiency.
Croatian: • Folitropin alfa se u kombinaciji s pripravkom luteinizirajućeg hormona (LH) preporučuje za stimulaciju razvoja folikula u žena s teškim nedostatkom LH-a i FSH-a.
English: Hold the pen at approximately a right angle and insert the needle completely in a steady movement.
Croatian: Brizgalicu držite otprilike pod pravim kutom i sigurnim pokretom ubodite iglu cijelom dužinom.
English: Do not throw away any medicines via your sink, toilet or in your household waste.
Croatian: Nikada nemojte nikakve lijekove bacati u sudoper, zahodsku školjku ili kućni otpad.
English: Comparative clinical trials have shown that on average patients require a lower cumulative dose and shorter treatment duration with follitropin alfa compared with urinary FSH.
Croatian: Usporedna klinička ispitivanja pokazala su da su pacijenticama u prosjeku potrebne manje kumulativne doze i kraće trajanje terapije folitropinom alfa u usporedbi s urinarnim FSH-om.
English: The dose is then adjusted according to the ovarian response.
Croatian: Nakon toga se doza prilagođava ovisno o odgovoru jajnika.
English: Therefore, if signs of ovarian hyperstimulation occur such as serum oestradiol level > 5,500 pg/mL or > 20,200 pmol/L and/or ≥ 40 follicles in total, it is recommended that hCG be withheld and the patient be advised to refrain from coitus or to use barrier contraceptive methods for at least 4 days.
Croatian: Stoga, ako se pojave simptomi hiperstimulacije jajnika, kao što su razina estradiola u serumu > 5 500 pg/ml ili > 20 200 pmol/l i/ili ≥ 40 folikula ukupno, preporučuje se prestanak primjene hCG-a, a pacijentica se treba suzdržavati od spolnog odnosa ili upotrebljavati mehaničke metode kontracepcije najmanje 4 dana.
English: In clinical trials, patients with severe FSH and LH deficiency were defined by an endogenous serum LH level < 1.2 IU/L as measured in a central laboratory.
Croatian: U kliničkim su ispitivanjima pacijentice s teškim nedostatkom FSH-a i LH-a definirane razinom endogenog LH-a u serumu < 1,2 IU/l, kako je izmjereno u središnjem laboratoriju.
English: Alternatively intrauterine insemination (IUI) may be performed.
Croatian: Alternativa je provođenje intrauterine inseminacije (IUI).
English: It is advised to adhere to the recommended starting doses indicated below.
Croatian: Uputno je pridržavati se početnih doza koje su navedene u daljnjem tekstu.
English: For example, after two weeks of GnRH agonist treatment, 150 to 225 IU Bemfola is administered for 7 days.
Croatian: Primjerice, nakon 2 tjedna primjene agonista GnRH-a započinje primjena 150 - 225 IU lijeka Bemfola tijekom 7 dana.
English: • Local reactions at the injection site, such as pain, redness, bruising, swelling and/or irritation
Croatian: • lokalne reakcije na mjestu injiciranja, kao što su bol, crvenilo, modrice, oticanje i/ili nadraženost
English: The steady state volume of distribution and total clearance are 10 L and 0.6 L/h, respectively.
Croatian: Volumen distribucije u stanju dinamičke ravnoteže iznosi 10 l, a ukupni klirens 0,6 l/sat.
English: What Bemfola is
Croatian: Što je Bemfola
English: How to use the Bemfola pre-filled pen 2.
Croatian: Kako koristiti napunjenu brizgalicu s lijekom Bemfola 2.
English: Remove the peel tab from the injection needle.
Croatian: Uklonite zaštitnu foliju s igle za injekciju.
English: Do not push the dosage knob in while attaching the needle.
Croatian: ne pritišćite dugme za doziranje dok spajate iglu.
English: If an excessive response is obtained, treatment should be stopped and hCG withheld (see section 4.4).
Croatian: U slučaju pretjeranog odgovora, potrebno je obustaviti terapiju i ne primijeniti hCG (vidjeti dio 4.4).
English: Before starting treatment, the reason for the couple's infertility must be thoroughly investigated and putative contraindications for pregnancy must be evaluated.
Croatian: Prije početka terapije mora se detaljno istražiti razlog neplodnosti para i moraju se ocijeniti pretpostavljene kontraindikacije za trudnoću.
English: Injecting the dose
Croatian: Injiciranje doze
English: No other clinically significant medicinal product interaction has been reported during follitropin alfa therapy.
Croatian: Ne postoje izvješća ni o jednoj drugoj klinički značajnoj interakciji između lijekova za vrijeme primjene folitropina alfa.
English: Once opened, the medicine should be injected immediately.
Croatian: Lijek se mora injicirati odmah nakon otvaranja.
English: When GnRH antagonist is used, it is administered from the 5th or 6th day of Bemfola treatment and continued until ovulation induction.
Croatian: GnRH-a, on se primjenjuje od 5. ili 6. dana liječenja lijekom Bemfola sve do nastupa ovulacije.
English: • to help develop several follicles (each containing an egg) in women undergoing assisted reproductive technology procedures (procedures that may help you to become pregnant) such as “in vitro fertilisation”, “gamete intra-fallopian transfer” or “zygote intra-fallopian transfer”.
Croatian: • kako bi se pomoglo u razvoju i sazrijevanju nekoliko folikula (svaki folikul sadrži jajnu stanicu) u žena koje se podvrgavaju tehnikama potpomognute oplodnje (postupcima koji Vam mogu pomoći da zatrudnite), kao što su „in vitro umjetna oplodnja“, „prijenos gamete u jajovod“ i „prijenos zigote u jajovod“.
English: There is no relevant use of follitropin alfa in the elderly population.
Croatian: Nema relevantne primjene folitropina alfa u starijoj populaciji.
English: If you are a woman, this medicine increases your risk of developing OHSS.
Croatian: Ako ste žena, ovaj lijek povećava rizik od razvoja sindroma hiperstimulacije jajnika (engl. ovarian hyper-stimulation syndrome, OHSS).
English: Before you start using your pre-filled pen
Croatian: Prije početka korištenja napunjene brizgalice
English: Women with a history of tubal disease are at risk of ectopic pregnancy, regardless of whether the pregnancy is obtained by spontaneous conception or with fertility treatments.
Croatian: Žene koje u anamnezi imaju bolest jajovoda izložene su većem riziku od ektopične trudnoće, bilo da je do trudnoće došlo spontanim začećem ili uz pomoć terapije za neplodnost.
English: When undergoing assisted reproductive technology the risk of having a multiple pregnancy is related to your age, the quality and the number of fertilised eggs or embryos placed inside you.
Croatian: Prilikom podvrgavanja tehnikama potpomognute oplodnje, rizik od višeplodne trudnoće povezan je s Vašom dobi te kvalitetom i brojem implantiranih oplođenih jajnih stanica ili embrija.
English: Hold the pen so that the needle is pointing upright.
Croatian: Primite brizgalicu tako da igla bude usmjerena prema gore.
English: Treatment should recommence in the next cycle at a dose lower than that of the previous cycle.
Croatian: Terapiju treba ponovno započeti u idućem ciklusu manjom dozom u odnosu na prethodni ciklus.
English: • When your eggs are ready, you will be given a single injection of 250 micrograms “recombinant hCG” (r-hCG, an hCG made in a laboratory by a special recombinant DNA technique), or
Croatian: • Kada su Vaše jajne stanice spremne, daje se jedna injekcija od 250 mikrograma „rekombinantnog hCG-a“ (r-hCG, hCG dobiven u laboratoriju posebnom DNK tehnikom) ili
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each mL of the solution contains 600 IU (equivalent to 44 micrograms) of follitropin alfa*.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Jedan ml otopine sadrži 600 IU (što odgovara 44 mikrograma) folitropina alfa*.
English: Do not use Bemfola
Croatian: Nemojte uzimati lijek Bemfola
English: Follitropin alfa is indicated for use in infertility (see section 4.1).
Croatian: Folitropin alfa je indiciran za primjenu kod neplodnosti (vidjeti dio 4.1).
English: Mild to severe hypersensitivity reactions including anaphylactic reactions and shock
Croatian: blage do teške reakcije preosjetljivosti, uključujući anafilaktičke reakcije i šok
English: Thromboembolism may occur very rarely (see section 4.4).
Croatian: Tromboembolija se javlja vrlo rijetko (vidjeti dio 4.4).
English: In ART, aspiration of all follicles prior to ovulation may reduce the occurrence of hyperstimulation.
Croatian: Kod metoda medicinski potpomognute oplodnje, aspiriranje svih folikula prije ovulacije može umanjiti pojavu hiperstimulacije.
English: 5,000 IU to 10,000 IU of hCG, 24 to 48 hours after the last Bemfola injection.
Croatian: 5 000 - 10 000 IU hCG-a 24 - 48 sati nakon posljednje injekcije lijeka Bemfola.
English: The prevalence of ectopic pregnancy after ART was reported to be higher than in the general population.
Croatian: Prevalencija ektopičnih trudnoća nakon potpomognute oplodnje veća je u usporedbi s općom populacijom.
English: Treatment in men Immune system disorders Very rare:
Croatian: Poremećaji imunološkog sustava Vrlo rijetko:
English: In women with anovulation, the objective of therapy with follitropin alfa is to develop a single mature Graafian follicle from which the ovum will be liberated after the administration of hCG.
Croatian: U žena s anovulacijom, cilj terapije folitropinom alfa je razviti jedan zreli Graafov folikul iz kojeg će se nakon primjene hCG-a osloboditi jajna stanica.
English: The pH of the solution is 6.7 - 7.3.
Croatian: Bistra, bezbojna otopina. pH otopine je 6,7 - 7,3.
English: For example, following two weeks of treatment with an agonist, 150-225 IU follitropin alfa are administered for the first 7 days.
Croatian: Primjerice, nakon dva tjedna primjene agonista započinje primjena 150-225 IU folitropina alfa tijekom prvih 7 dana.
English: There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple treatment regimens for infertility treatment.
Croatian: Postoje izvješća o neoplazmama jajnika i drugih dijelova reprodukcijskog sustava, kako benignima tako i malignima, u žena koje su prošle više ciklusa liječenja neplodnosti.
English: Patients undergoing stimulation of follicular growth, whether as treatment for anovulatory infertility or ART procedures, may experience ovarian enlargement or develop hyperstimulation.
Croatian: Pacijentice kod kojih se provodi stimulacija rasta folikula, bilo kao terapija za anovulatornu neplodnost ili zbog procedura vezanih uz metode medicinski potpomognute oplodnje, mogu doživjeti povećanje jajnika ili razviti hiperstimulaciju.
English: • If you use Bemfola with other medicines which help ovulation (such as hCG or clomiphene citrate), this may increase the response of your follicles.
Croatian: • Primjena lijeka Bemfola s drugim lijekovima koji stimuliraju ovulaciju (na primjer, hCG ili klomifencitrat) može povećati folikularni odgovor.
English: 4.7 Effects on ability to drive and use machines Follitropin alfa is expected to have no or negligible influence on the ability to drive and use machines.
Croatian: Očekuje se da folitropin alfa neće utjecati ili da će zanemarivo utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Paediatric population There is no relevant use of follitropin alfa in the paediatric population.
Croatian: Pedijatrijska populacija Nema relevantne primjene folitropina alfa u pedijatrijskoj populaciji.
English: Comparison with historical data suggests that the ovulation rate obtained with follitropin alfa/LH is similar to that obtained with hMG.
Croatian: Usporedbe utemeljene na dosadašnjim podacima ukazuju na to da je stopa ovulacije postignuta kombinacijom folitropina alfa/LH slična onoj postignutoj hMG-om.
English: Treatment should be tailored to the individual patient's response as assessed by measuring follicle size by ultrasound and estrogen response.
Croatian: Terapiju treba prilagoditi individualnom odgovoru pacijentice, koji procjenjujemo mjerenjem veličine folikula ultrazvukom i mjerenjem odgovora estrogena.
English: • The other ingredients are poloxamer 188, sucrose, methionine, disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, phosphoric acid and water for injections.
Croatian: • Drugi sastojci su poloksamer 188, saharoza, metionin, natrijev hidrogenfosfat dihidrat, natrijev dihidrogenfosfat dihidrat, fosfatna kiselina i voda za injekcije.
English: If you had in the past or recently blood clots in the leg or in the lung, or a heart attack or stroke, or if those happened in your family, then you might have a higher risk that these problems occur or become worse with Bemfola treatment.
Croatian: Ako ste nedavno ili u prošlosti imali krvne ugruške u nogama ili plućima, ili srčani ili moždani udar,
English: Pack sizes of 1, 5 and 10 pre-filled pens including one disposable needle and alcohol swab per pen.
Croatian: Veličine pakiranja: 1, 5 i 10 napunjenih brizgalica, uključujući jednu iglu za jednokratnu upotrebu i jastučić od vate natopljen alkoholom po brizgalici.
English: Treatment should be tailored to the individual patient's response as assessed by measuring follicle size by ultrasound and/or estrogen secretion.
Croatian: Terapiju treba prilagoditi individualnom odgovoru pacijentice, koji se procjenjuje mjerenjem veličine folikula ultrazvukom i/ili mjerenjem lučenja estrogena.
English: Impaired fertility has been reported in rats exposed to pharmacological doses of follitropin alfa (≥ 40 IU/kg/day) for extended periods, through reduced fecundity.
Croatian: U štakora koji su bili izloženi farmakološkim dozama folitropina alfa (≥ 40 IU/kg na dan) tijekom duljih razdoblja dokazano je smanjenje plodnosti.
English: 1.5 mL cartridge (type I glass), with a plunger stopper (halobutyl rubber) and an aluminium crimp cap with a rubber inlay, assembled in a pre-filled pen.
Croatian: 1,5 ml uložak (staklo tipa I), s čepom klipa (halobutilna guma) i aluminijskim sigurnosnim zatvaračem iznutra obloženim s gumom, sastavljen u napunjenu brizgalicu.
English: Serious side effects in women
Croatian: Ozbiljne nuspojave u žena
English: If your doctor cannot see a desired response after 4 weeks, that treatment cycle with Bemfola should be stopped.
Croatian: Ako Vaš liječnik ne primijeti željeni odgovor nakon 4 tjedna terapije, taj ciklus liječenja lijekom Bemfola treba prekinuti.
English: • Breast development, acne or weight gain.
Croatian: • razvoj dojki, akne ili povećanje tjelesne težine
English: Solution for injection 1 pre-filled pen 1 injection needle 1 alcohol swab
Croatian: Otopina za injekciju 1 napunjena brizgalica 1 igla za injekciju
English: Hold the pen by its sides and attach the needle by clicking it into place.
Croatian: Držite brizgalicu za bočne strane i spojite iglu tako da je nataknete ravno na brizgalicu.
English: Poloxamer 188, sucrose, methionine, disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, phosphoric acid and water for injections.
Croatian: Poloksamer 188, saharoza, metionin, natrijev hidrogenfosfat dihidrat, natrijev dihidrogenfosfat dihidrat, fosfatna kiselina i voda za injekcije.
English: If you get lower abdominal pain, gain any weight rapidly, feel sick or are vomiting or if you have difficulty in breathing, talk to your doctor straight away who might ask you to stop using this medicine (see section 4).
Croatian: Ako osjetite bol u donjem dijelu trbuha, brzo dobivate na težini, osjećate mučninu ili povraćate, ili otežano dišete, odmah se obratite svom liječniku.
English: If an FSH dose increase is deemed appropriate, dose adaptation should preferably be at 7-14 day intervals and preferably with 37.5-75 IU increments.
Croatian: Ako se utvrdi da treba povećati dozu FSH-a, poželjno je prilagođavati dozu u intervalima od 7 do 14 dana, po mogućnosti u koracima od 37,5 do 75 IU.
English: Do not administered the solution if it contains particles or is not clear.
Croatian: Ne primjenjujte otopinu ako sadrži čestice ili nije bistra.
English: • Follitropin alfa is indicated for the stimulation of spermatogenesis in men who have congenital or acquired hypogonadotrophic hypogonadism with concomitant human Chorionic Gonadotropin (hCG) therapy.
Croatian: U odraslih muškaraca • Folitropin alfa je indiciran za stimulaciju spermatogeneze u muškaraca s kongenitalnim ili stečenim hipogonadotropnim hipogonadizmom uz istodobnu terapiju humanim korionskim gonadotropinom (engl. human Chorionic Gonadotropin, hCG).
English: Given in high doses (≥ 5 IU/kg/day) follitropin alfa caused a decrease in the number of viable foetuses without being teratogenic, and dystocia similar to that observed with urinary menopausal gonadotropin (hMG).
Croatian: Primjena visokih doza (≥ 5 IU/kg na dan) folitropina alfa uzrokuje smanjenje broja vitalnih fetusa bez teratogenog učinka, te distociju sličnu onoj koja se javlja kod urinarnog menopauzalnog gonadotropina (hMG).
English: Setting the dose
Croatian: Određivanje doze
English: with a condition that usually makes normal pregnancy impossible, such as ovarian failure (early menopause), or malformed reproductive organs.
Croatian: - ako postoji stanje zbog kojeg normalna trudnoća nije moguća, kao što su zatajenje rada jajnika (preuranjena menopauza) ili nepravilan oblik spolnih organa • ako ste muškarac:
English: Independent risk factors for developing OHSS include polycystic ovarian syndrome, high absolute or rapidly rising serum oestradiol levels (e.g. > 900 pg/mL or > 3,300 pmol/L in anovulation; > 3,000 pg/mL or > 11,000 pmol/L in ART) and large number of developing ovarian follicles (e.g. > 3 follicles of ≥ 14 mm in diameter in anovulation; ≥ 20 follicles of ≥ 12 mm in diameter in ART).
Croatian: Neovisni faktori rizika za razvoj OHSS-a uključuju sindrom policističnih jajnika, visoku apsolutnu razinu ili brzo rastuću razinu estradiola u serumu (npr. > 900 pg/ml ili > 3 300 pmol/l tijekom anovulacije; > 3 000 pg/ml ili > 11 000 pmol/l tijekom medicinski potpomognute oplodnje) i velik broj folikula jajnika u razvoju (npr. > 3 folikula promjera ≥ 14 mm tijekom anovulacije; ≥ 20 folikula promjera ≥ 12 mm tijekom medicinski potpomognute oplodnje).
English: In clinical trials, an increase of the ovarian sensitivity to follitropin alfa was shown when administered with lutropin alfa.
Croatian: U kliničkim je ispitivanjima dokazana povećana osjetljivost jajnika na folitropin alfa kada se on primjenjivao zajedno s lutropinom alfa.
English: The solution should not be administered if it contains particles or is not clear.
Croatian: Otopina se ne smije primijeniti ako sadrži čestice ili nije bistra.
English: Severe OHSS is uncommon (see section 4.4).
Croatian: Teški OHSS je manje čest (vidjeti dio 4.4).
English: • Bemfola is intended to be given by injection just under the skin (subcutaneously).
Croatian: • Bemfola je namijenjena za potkožnu primjenu injekcijom (supkutano).
English: In clinical trials comparing r-hFSH (follitropin alfa) and urinary FSH in ART (see table 1 below) and in ovulation induction, follitropin alfa was more potent than urinary FSH in terms of a lower total dose and a shorter treatment period needed to trigger follicular maturation.
Croatian: Klinička ispitivanja koja su uspoređivala r-hFSH (folitropin alfa) i urinarni FSH pri medicinski potpomognutoj oplodnji (vidjeti tablicu 1 ispod) i indukciji ovulacije pokazale su da je folitropin alfa učinkovitiji od urinarnog FSH-a u smislu manje ukupne doze i kraćeg vremena terapije potrebnog za poticanje sazrijevanja folikula.
English: Each mL of the solution contains 600 IU equivalent to 44 micrograms.
Croatian: Jedan ml otopine sadrži 600 IU, što odgovara 44 mikrograma.
English: Replace the outer needle cap onto the needle carefully.
Croatian: Pažljivo vratite vanjski zatvarač na iglu.
English: Multiple pregnancy, especially of high order, carries an increased risk of adverse maternal and perinatal outcomes.
Croatian: Višeplodna trudnoća, pogotovo ona s velikim brojem plodova, nosi povećan rizik od neželjenih pojava u vrijeme trudnoće i u perinatalnom razdoblju.
English: Discard used pen and needle immediately after injection.
Croatian: Iskorištene brizgalica i igla moraju se odložiti u otpad odmah nakon injiciranja.
English: Concomitant use of follitropin alfa with other medicinal products used to stimulate ovulation (e.g. hCG, clomiphene citrate) may potentiate the follicular response, whereas concurrent use of a GnRH agonist or antagonist to induce pituitary desensitisation may increase the dose of follitropin alfa needed to elicit an adequate ovarian response.
Croatian: 4.5 Interakcije s drugim lijekovima i drugi oblici interakcija Istodobna primjena folitropina alfa s drugim lijekovima koji se koriste za stimuliranje ovulacije (na primjer hCG, klomifencitrat) može pojačati folikularni odgovor, dok istodobna primjena agonista ili antagonista GnRH-a u cilju smanjenja osjetljivosti hipofize može povećati dozu folitropina alfa potrebnu za postizanje adekvatnog odgovora jajnika.
English: The most commonly reported adverse reactions are headache, ovarian cysts and local injection site reactions (e.g. pain, erythema, haematoma, swelling and/or irritation at the site of injection).
Croatian: Najčešće prijavljivane nuspojave obuhvaćaju glavobolju, ciste na jajnicima i lokalne reakcije na mjestu injiciranja (npr. bol, eritem, hematom, oticanje i/ili iritacija na mjestu injiciranja).
English: • to help release an egg from the ovary (ovulation) in women that cannot ovulate and that did not respond to treatment with a medicine called “clomiphene citrate”.
Croatian: • za poticanje oslobađanja jajne stanice iz jajnika (ovulacije) u žena koje ne ovuliraju i koje nisu odgovorile na terapiju lijekom „klomifencitrat“.
English: The prevalence of congenital malformations after ART may be slightly higher than after spontaneous conceptions.
Croatian: Prevalencija kongenitalnih malformacija nakon primjene metoda medicinski potpomognute oplodnje može biti blago povećana u odnosu na spontana začeća.
English: • fibroid tumours of the uterus incompatible with pregnancy;
Croatian: • fibroidni tumori maternice nespojivi s trudnoćom
English: One needle and one alcohol swab to be used with the pen for administration.
Croatian: Jedna igla i jedan jastučić od vate natopljen alkoholom, za uporabu kod primjene brizgalicom.
English: Reproductive system neoplasms
Croatian: Neoplazme u reprodukcijskom sustavu
English: Treatment should recommence in the next cycle at a dose of FSH lower than that of the previous cycle.
Croatian: Terapiju treba ponovno započeti u idućem ciklusu dozom FSH-a koja je manja u odnosu na prethodni ciklus.
English: Following repeated administration, follitropin alfa accumulates 3-fold achieving a steady state within 3-4 days.
Croatian: Nakon ponovljene primjene, folitropin alfa nakuplja se trostruko, a stanje dinamičke ravnoteže postiže se nakon 3 - 4 dana.
English: Women with anovulation resulting from severe LH and FSH deficiency In LH and FSH deficient women (hypogonadotropic hypogonadism), the objective of follitropin alfa therapy in association with lutropin alfa is to develop a single mature Graafian follicle from which the oocyte will be liberated after the administration of human chorionic gonadotropin (hCG).
Croatian: Kod žena s nedostatkom LH-a i FSH-a (hipogonadotropni hipogonadizam), cilj terapije folitropinom alfa u kombinaciji s lutropinom alfa je razviti jedan zreli Graafov folikul iz kojeg će se osloboditi oocit nakon primjene humanog korionskog gonadotropina (hCG).
English: Within its shelf life, the unopened pen may be stored at or below 25°C for up to 3 months without being refrigerated again and must be discarded if it has not been used after 3 months.
Croatian: Unutar roka valjanosti, neotvorena brizgalica može se čuvati na temperaturi od ili ispod 25 °C do 3 mjeseca bez ponovnog odlaganja u hladnjak i mora se zbrinuti ako se ne iskoristi nakon 3 mjeseca.