FrancophonIA/ELRC3.0 huggingface dataset:
English: Pharmacotherapeutic group: antivirals for systemic use, protease inhibitors ATC code: J05AE03
Maltese: Kategorija farmakoterapewtika: antiretrovirali għall-użu sistematiku, impedituri protejaż Kodiċi ATC:
English: Tablet dose
Maltese: Doża tal-pillola
English: QTcF interval was evaluated in a randomised, placebo and active (moxifloxacin 400 mg once daily) controlled crossover study in 45 healthy adults, with 10 measurements over 12 hours on Day 3.
Maltese: L-intervall QTcF ġie evalwat fi studju tat-tip crossover li sar b'ordni addoċċ li kien ikkontrollat millplaċebo u attiv (moxifloxacin 400 mg darba kuljum) li sar fuq 45 adult f'saħħtu, fejn f'Ġurnata 3, ġie mkejjel 10 darbiet fi 12-il siegħa.
English: Co-administered Medicinal Products
Maltese: TAL-PRODOTT MEDIĊINALI
English: Norvir 100 mg film-coated tablets ritonavir
Maltese: Norvir 100 mg pilloli miksija b'rita ritonavir
English: Package leaflet: Information for the user Norvir 100 mg powder for oral suspension ritonavir
Maltese: Informazzjoni għall-utent Norvir 100 mg trab għal suspensjoni orali ritonavir
English: A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 (e.g., beclomethasone).
Maltese: Għandu jiġi kkunsidrat tnaqqis fid-doża tal-glucocorticoid u ssir osservazzjoni millqrib tal-effetti lokali u sistematiċi, jew jingħata glucocorticoid ieħor minflok, li m'huwiex sustanza li fuqa taħdem is-CYP3A4 (e.ż., beclomethasone).
English: ↓ 40% ND Ritonavir increases the serum levels of tipranavir as a result of CYP3A inhibition.
Maltese: Ritonavir ↓ 40% MD Bħala riżultat ta' impediment minn CYP3A, ritonavir iżid il-livelli tas-serum ta' tipranavir.
English: Co-administration of tipranavir with 200 mg of ritonavir has been associated with reports of clinical hepatitis and hepatic decompensation including some fatalities.
Maltese: Meta tipranavir huwa mogħti ma' 200 mg ta' ritonavir, ġie assoċjat ma' rapporti ta' epatite klinika u dikompensazzjoni epatika, inkluż xi fatalitajiet.
English: If Norvir is co-administered with parenteral midazolam, it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Maltese: Jekk Norvir jingħata flimkien ma' midazolam parenterali, dan għandu jseħħ f'post għal kura intensiva (ICU) jew post simili fejn ikunu jsiru osservazzjoni klinikali mill-qrib u treġija medika adegwata f'każ li jkun hemm deppressjoni respiratorja u/jew sedazzjoni twila aktar milli sippost.
English: A higher frequency of adverse reactions (e.g., dizziness, nausea, paraesthesia) and laboratory abnormalities (elevated liver enzymes) have been observed when efavirenz is co-administered with ritonavir dosed as an antiretroviral agent.
Maltese: Frekwenza ogħla ta' reazzjonijiet avversi (e.ż., sturdament, nawseja, parasteżija) u abnormalitajiet firriżultati tal-laboratorju (enzimi tal-fwied għoljin) ġew innotati meta efavirenz jingħata ma' ritonavir f'doża bħala aġent antiretrovali.
English: Ritonavir pharmacokinetic parameters were not statistically significantly associated with body weight or lean body mass. Ritonavir plasma exposures in patients 50 - 70 years of age when dosed 100 mg in combination with lopinavir or at higher doses in the absence of other protease inhibitors is similar to that observed in younger adults.
Maltese: L-esponimenti fil-plażma b'ritonavir f'pazjenti ta' bejn 50 - 70 sena meta dożati b'100 mg jew dożi akbar flimkien ma' lopinavir, huma simili għall-esponimenti osservati f'adulti iżgħar meta ma jkunx hemm impedituri ta' protejaż oħra.
English: • if your doctor prescribes a full dose, adults may be started on a dose of 3 tablets in the morning and 3 tablets 12 hours later, gradually increasing over a period of up to 14 days to the full dose of 6 tablets twice daily (totaling 1,200mg per day).
Maltese: • jekk it-tabib tiegħek jagħtik doża sħiħa, l-adulti jistgħu jibdew fuq doża ta' 3 pilloli filgħodu u 3 pilloli 12 -il siegħa wara, u bil-mod il-mod iżidu, fuq perijodu ta' żmien sa 14 -il ġurnata, għal doża sħiħa ta' 6 pilloli darbtejn kuljum (li jammontaw għal total ta' 1,200 mg kuljum).
English: 500 q12h ↑ 3.4-fold
Maltese: 600 q12h ↑ 49 darba
English: Concomitant use of ritonavir (500 mg twice daily) dosed as an antiretroviral agent and rifabutin due to an increase of rifabutin serum concentrations and risk of adverse reactions including uveitis (see section 4.4).
Maltese: L-użu ta' ritonavir (500 mg darbtejn kuljum) mogħti f'doża bħala aġent antiretrovirali flimkien ma' rifabutin minħabba żieda fil-konċentrazzjoni fis-serum ta' rifabutin u riskju ta' effetti avversi , li jinkludu l-inflammazzjoni tal-uvea (ara sezzjoni 4.4).
English: Although rifampicin may induce metabolism of ritonavir, limited data indicate that when high doses of ritonavir (600 mg twice daily) is co-administered with rifampicin, the additional inducing effect of rifampicin (next to that of ritonavir itself) is small and may have no clinical relevant effect on ritonavir levels in high-dose ritonavir therapy.
Maltese: Għalkemm rifampicin jista' jġiegħel il-metaboliżmu ta' ritonavir, informazzjoni limitata tindika, li meta dożi għolja ta' ritonavir (600 mg darbtejn kuljum) jingħataw flimkien ma' rifampicin, l-effett addizzjonali li jġiegħel rifampicin (meta mqabbel ma' dak ta' ritonavir innifsu) huwa żgħir u jista' jkun li ma jħallix effett li huwa klinikament sinifikanti fuq illivelli ta' ritonavir f'każ ta' terapija fejn jingħataw dożi għoljin ta' ritonavir.
English: ↑ 178% ND
Maltese: ↑ 178% MD Ritonavir ↑ 72% MD
English: Pharmaco-therapeutic group: antiviral for systemic use, protease inhibitors ATC code: J05AE03
Maltese: Kategorija farmakoterapewtika: antiretrovirali għall-użu sistematiku, impedituri tal-proteaż Kodiċi ATC:
English: 30 film-coated tablets 60 film-coated tablets
Maltese: GĦAMLA FARMAĊEWTIKA U KONTENUT 30 pillola miksija b'rita
English: 200 q12h, 2 days
Maltese: 200 q12h, 2 (jumejn)
English: The maximum mean (95% upper confidence bound) difference in QTcF from placebo was 5.5 (7.6) for 400 mg twice daily ritonavir.
Maltese: Id-differenza medja massima (95% upper confidence bound) filQTcF mill-plaċebo kienet ta' 5.5 ( 7.6) fejn ingħatat doża ta' 400 mg ritonavir darbtejn kuljum. Lesponiment ta' ritonavir f'Ġurnata 3 kien ta' bejn wieħed u ieħor 1.5 drabi aktar għoli minn dak osservat meta ngħatat doża ta' 600 mg darbtejn kuljum.
English: - Norvir is not a cure for HIV infection or AIDS.
Maltese: - Norvir m'huwiex trattament għall-infezzjoni tal-HIV jew l-AIDS.
English: Lopinavir co-formulated with ritonavir (lopinavir/ritonavir) 400 mg/100 mg or 800 mg/200 mg. Saquinavir 1000 mg twice daily with ritonavir 100 mg twice daily in ART experienced patients.
Maltese: 600 mg ampremavir darbtejn kuljum flimkien ma' 100 mg ritonavir darbtejn kuljum 300 mg atazanavir darba kuljum flimkien ma' 100 mg ritonavir darba kuljum 700 mg fosamprenavir darbtejn kuljum flimkien ma' 100mg ritonavir darbtejn kuljum lopinavir imħallta ma' 100 mg ritonavir f'taħlita waħda (lopinavir/ritonavir) 400 mg/100 mg jew 800 mg/200mg.
English: Do not use Norvir powder for oral suspension after the expiry date on the sachet and carton.
Maltese: Tużax Norvir trab għal suspensjoni orali wara d-data ta' skadenza li tidher fuq il-qartas u l-kartuna.
English: Medicinal product interactions - Ritonavir with antiretroviral agents other than protease inhibitors Coadministered
Maltese: Interazzjonijiet tal-Prodotti Mediċinali - Ritonavir ma' Aġenti Antiretrovirali minbarra Impedituri
English: 500 mg in the morning and 500 mg in the evening
Maltese: 500 mg filgħodu u 500 mg filgħaxija
English: - Steroids (e.g. dexamethasone, fluticasone propionate, prednisolone, triamcinolone) as Norvir may raise the blood levels of these medicines which may lead to Cushing's syndrome (development of a rounded face) and reduce production of the hormone cortisol.
Maltese: - Sterojdi (eż. dexamethasone, fluticasone propionate, prednisolone, triamcinolone) għax Norvir jista' jżid il-livelli fid-demm ta' dawn il-mediċini li jista' jwassal għas-sindromu Cushing (Cushing's syndrome) (żvilupp ta' wiċċ tond) u jnaqqas il-produzzjoni tal-ormon cortisol.
English: The co-administration of riociguat with Norvir is not recommended (see section 4.4 and refer to riociguat SmPC).
Maltese: L-għoti flimkien ta' riociguat ma' Norvir m'huwiex irrakkomandat (ara sezzjoni 4.4 u irreferi għal SMPC ta' riociguat).
English: For further information, refer to the Summary of Product Characteristics for maraviroc.
Maltese: Għal aktar informazzjoni, irreferi għas-Sommarju tal-Karatteristiċi tal-Prodott ta' maraviroc.
English: Mix the powder and liquid a.Tightly screw on the lid and keep shaking the mixing cup hard for at least 90 seconds until all the lumps have gone.
Maltese: Ħallat it-trab u likwidu a.Issika l-għatu sew u kompli ħawwad it-tazza tattaħlit għal mill-inqas 90 sekonda sakemm iċ-ċapep ikunu telqu kollha.
English: (If required)
Maltese: (platelets)
English: ↑ 7.2-fold
Maltese: ↑bi 7.2 drabi
English: • wind (flatulence)
Maltese: • għatx (deidratazzjoni)
English: 52.6 ml (526 mg) *When mixed with 9.4 ml of liquid the concentration of the suspension is 10 mg/ml.
Maltese: * Meta mħallat ma' 9.4 ml ta' likwidu l-konċentrazzjoni tas-suspensjoni hi 10 mg/mL.
English: Zidovudine 200 q8h
Maltese: 200 q8h
English: fosamprenavir, indinavir, nelfinavir, saquinavir, tipranavir) non-nucleoside reverse transcriptase inhibitors( NNRTI) (delavirdine, efavirenz, nevirapine), and others (didanosine, maraviroc,
Maltese: li m'humiex nucleòside (NNRTI) (delavirdine, efavirenz, nevirapine), and others (didanosine,
English: Saquinavir4 ↑ 17-fold ND
Maltese: Darunavir ↑ b'14 -il darba
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of erythromycin and itraconazole.
Maltese: Ritonavir dożat biex iżid l-effett farmakokinetiku jew bħala aġent antiretrovirali jimpedixxi s-CYP3A4, u għalhekk huwa mistenni li jżid ilkonċentrazzjoni fil-plażma ta' erythromycin u itraconazole.
English: ↑ 15-fold ↑ 5-fold
Maltese: 55, doża waħda
English: Norvir powder for oral suspension should be stored below 30°C.
Maltese: Norvir trab għal suspensjoni orali għandhu jinħażen f'temperatura taħt 30C.
English: Do not use Norvir after the expiry date on the label.
Maltese: Tużax Norvir wara d-data ta' skadenza li tidher fuq it-tabella.
English: Ritonavir is likely to change the uterine bleeding profile and reduce the effectiveness of estradiol-containing contraceptives (see section 4.4).
Maltese: X'aktarx li ritonavir ibiddel il-profil ta' telf ta' demm mill-ġuf u jnaqqas l-effettivita ta' kontraċettivi li jkun fihom estradiol (ara sezzjoni 4.4).
English: Concomitant use of avanafil or vardenafil with ritonavir is contraindicated (see section 4.3).
Maltese: L-użu ta' avanafil jew vardenafil flimkien ma' ritonavir huwa kontro-indikat (ara sezzjoni 4.3).
English: Animal studies do not indicate harmful effects of ritonavir on fertility (see section 5.3).
Maltese: Studji fl-annimali ma jindikawx effetti ta' ħsara ta' ritonavir fuq il-fertilità (ara sezzjoni 5.3).
English: Indinavir3
Maltese: ANNESS III
English: Initiate treatment with saquinavir 500 mg twice daily with ritonavir 100 mg twice daily for the first 7 days, then saquinavir 1000 mg twice daily with ritonavir 100 mg twice daily in ARTnaïve patients.
Maltese: 1000 mg saquinavir darbtejn kuljum ma' 100 mg ritonavir darbtejn kuljum f'pazjenti li diġa ħadu ART. Ibda it-trattament b'500 mg saquinavir darbtejn kuljum flimkien ma' 100mg ritonavir darbtejn kuljum fl-ewwel sebat ijiem, imbagħad 1000 mg saquinavir darbtejn kuljum flimkien ma' 100 mg ritonavir darbtejn kuljum f'pazjenti li ma ħadux trattament bl-ART qabel. 500 mg tipranavir darbtejn kuljum flimkien ma' 200 mg ritonavir darbtejn kuljum.
English: Clinical trials confirmed the safety and efficacy of 300 mg atazanavir once daily with ritonavir 100 mg once daily in treatment experienced patients.
Maltese: Provi kliniċi kkonfermaw is-sigurta u l-effikaċja ta' 300 mg atazanavir darba kuljum ma' 100 mg ritonavir darba kuljum fuq pazjenti li għandhom esperjenza tat-trattament.
English: 400 mg in the morning and 300 mg in the evening
Maltese: 400 mg filgħodu u 300 mg filgħaxija
English: Immune Reconstitution Inflammatory Syndrome
Maltese: Sindromu ta' rikostruzzjoni infjammatorja tal-imunita
English: The HMG-CoA reductase inhibitors simvastatin and lovastatin are highly dependent on CYP3A for metabolism, thus concomitant use of ritonavir with simvastatin or lovastatin is not recommended due to an increased risk of myopathy including rhabdomyolysis.
Maltese: Il-metaboliżmu ta' pravastatin u fluvastatin ma jiddependix minn CYP3A, u interazzjonijiet ma ritonavir m'humiex mistennija.
English: Clinical trials confirmed the safety and efficacy of 600 mg amprenavir twice daily with ritonavir 100 mg twice daily.
Maltese: Provi kliniċi kkonfermaw is-sigurta u l-effikaċja ta' 600 mg amprenavir darbtejn kuljum flimkien ma' 100 mg ritonavir darbtejn kuljum.
English: PHARMACOLOGICAL PROPERTIES 5.1 Pharmacodynamic properties
Maltese: .1 Proprjetajiet farmakodinamiku
English: 176 mg (17.6 ml) twice daily
Maltese: 176 mg (17.6 ml) darbtejn kuljum200 mg filgħodu u 200 mg filgħaxija
English: The prescribed dose of Norvir powder for oral suspension can be administered via a feeding tube after being mixed with water as detailed in section 6.6.
Maltese: Id-doża preskritta ta' Norvir trab għal-suspensjoni orali tista' tingħata permezz ta' tubu talalimentazzjoni wara li jitħallat mal-ilma kif inhu spjegat fis-sezzjoni 6.6.
English: Individual SmPCs should be consulted.
Maltese: Għandhom jiġu konsultati l-SmPCs individwali.
English: 0.5 single IV dose 300 q12h, 3 days
Maltese: 0.125 doża waħda 200, 4 dożi
English: Animal studies as well as in vitro experiments with human hepatic microsomes indicated that ritonavir primarily underwent oxidative metabolism.
Maltese: Studji fuq lannimali, kif ukoll esperimenti in vitro b'mikrosomi epatiċi tal-bniedem urew li primarjament ritonavir għadda minn metaboliżmu ossidattiv.
English: Across dose groups, ritonavir oral clearance (CL/F/m2) was approximately 1.5 to 1.7 times faster in paediatric patients above 2 years of age than in adult subjects.
Maltese: Bejn il-gruppi ta'doża differenti it tneħħija ta' ritonavir mill-ħalq (cl/F/m2) kienet ta' bejn wieħed u ieħor minn 1.5 sa 1.7 drabi aktar mgħaġġla f'pazjenti pedjatriċi li kellhom iżjed minn sentejn, milli minn suġġetti adulti.
English: (See section 4.
Maltese: (ara sezzjoni 4.2).
English: Based on parallel group comparison.
Maltese: Ibbażat fuq paragun ta' gruppi paralleli.
English: Because of the potential for (1) HIV transmission (in HIV-negative infants), (2) developing viral resistance (in HIV-postive infants) and (3) serious adverse reactions in a breastfed infant, HIV infected women should not breast feed their infants under any circumstances if they are receiving Norvir.
Maltese: Minħabba l-potenzjal għal (1) trażmissjoni ta' HIV (fi trabi b'HIV negattiv), (2) jiżviluppaw reżistenza virali (fi trabi b'HIV pożittiv) u (3) reazzjonijiet avversi serji fi trabi mreddgħa, nisa infettati bl-HIV m'għandhomx ireddgħu it-trabi tagħhom taħt kwalunkwe ċirkostanza jekk qed jirċievu Norvir.
English: In cases of co-administration of ritonavir (100 mg twice daily) and indinavir (800 mg twice daily) caution is warranted as the risk of nephrolithiasis may be increased.
Maltese: F'każi tat-teħid flimkien ta' ritonavir (100 mg darbtejn kuljum) u indinavir (800 mg darbtejn kuljum) għandha tiġi eżerċitata attenzjoni minħabba li r-riskju ta' ġebla fil-kliewi jista' jiżdied.
English: Induction of CYP1A2 and CYP2C9 lead to decreased levels of Rwarfarin while little pharmacokinetic effect is noted on S- warfarin when co-administered with ritonavir.
Maltese: Fil-waqt li l-effett farmakokinetiku innotat fuq S-warfarin meta dan ittieħed ma' ritonavir huwa żgħir, l-induzzjoni ta' CYP1A2 u CYP2C9 wassal għal tnaqqis fil-livelli ta' R-warfarin.
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer to the relevant product information for these medicinal products.
Maltese: F'kaz ta' terapija konkomitanti antiretrovirali għall-epatite B jew C, jekk jogħġbok irreferi għall-informazzjoni dwar il-prodott relatat ma' dawn il-prodotti mediċinali.
English: Saquinavir4 ↑ 15-fold ↑ 5-fold Ritonavir
Maltese: fis-saqajn jew madwar ix-xofftejn u l-ħalq
English: 500 mg in the morning and 400 mg in the evening
Maltese: 500 mg filgħodu u 400 mg filgħaxija
English: Concomitant administration of glecaprevir/pibrentasvir and Norvir is not recommended due to an increased risk of ALT elevations associated with increased glecaprevir exposure.
Maltese: L-użu fl-istess ħin ta' glecaprevir/pibrentasvir ma' Norvir mhux irrakkomandat minħabba riskju akbar ta' żidiet fil-livelli ta' ALT assoċjati ma' żieda fl-esponiment għal glecaprevir.
English: Across dose groups, ritonavir oral clearance (CL/F/m2)
Maltese: Ctrough (g/ml) AUC12 or 24 (g•h/ml) t½ (h)
English: 262.5 mg (26.4 ml) twice daily
Maltese: 262.5 mg (26.4 ml) darbtejn kuljum
English: Each sachet of powder for oral suspension contains 100 mg of ritonavir.
Maltese: Kull qartas ta' trab għal suspensjoni orali fih 100 mg ta' ritonavir .
English: Ritonavir concentrations obtained after 350 to 400 mg/m² twice daily in paediatric patients were comparable to those obtained in adults receiving 600 mg (approximately 330 mg/m²) twice daily.
Maltese: Il-konċentrazzjoni ta' ritonavir li ntlaħqet f'pazjenti pedjatriċi wara doża ta' bejn 350 u 400 mg/m darbtejn kuljum kienet komparabbli ma' dik li ntlaħqet mill-adulti li kienu qegħdin jirċievu 600 mg (bejn wieħed u ieħor 330 mg/m ²) darbtejn kuljum.
English: Cl/F (L/h) 1 Values expressed as geometric means.
Maltese: Cl/F (L/h)
English: Weight and metabolic parameters:
Maltese: Parametri tal-metaboliċi
English: Based on cross-study comparison to 1200 mg amprenavir twice daily alone.
Maltese: Ibbażat fuq studju komparattiv li jinqeleb ma' 1200 mg amprenavir darbtejn kuljum waħdu 2.
English: Body surface area can be calculated with the following equation: BSA (m2) = √(Height (cm) X Weight (kg) /
Maltese: L-erja tas-superfiċje tal-ġisem tista' tiġi kkalkulata bl-ekwazzjoni segwenti BSA (m²) = √(Tul (cm) X Piż (kg) / 3600)
English: ↑ 11 fold ↑ 29 fold
Maltese: ↑ b'29 darba
English: 3 mg/kg q8h 500 q12h ↓ 43% An increased dose of theophylline may be required when co-administered with ritonavir, due to induction of CYP1A2.
Maltese: 200 kuljum 500 q12h ↑ bi 3.4 drabi Ritonavir jimpedixxi l-metaboliżmu medjat b' CYP3A ta' ketoconazole.
English: Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infected patients (adults and children of 2 years of age and older).
Maltese: Ritonavir huwa indikat li jittieħed flimkien ma' aġenti oħra antiretrovirali għat-trattament ta' pazjenti infettati bl-HIV-1 (adulti u tfal ta' sentejn jew aktar fl-eta`).
English: Step 3.
Maltese: ↑ bi 3-7
English: Tear open sachet (see Figure 3).
Maltese: Qatta u iftaħ l-qartas (ara Figura 3).
English: Patients who exhibit these signs or symptoms should be evaluated and Norvir therapy should be discontinued if a diagnosis of pancreatitis is made (see section 4.8).
Maltese: Pazjenti li juru dawn is-sinjali jew sintomi għandhom ikunu evalwati, u t-trattament b'Norvir għandu jitwaqqaf f'każ li jkun hemm dijanjosi ta' pankreatite (ara sezzjoni 4.8).
English: Apalutamide is a moderate to strong CYP3A4 inducer and this may lead to a decreased exposure of ritonavir and potential loss of virologic response.
Maltese: Apalutamide huwa induttur moderat sa qawwi ta' CYP3A4 u dan jista' jwassal għal tnaqqis fl-esponiment għal ritonavir u telf potenzjali ta' rispons viroloġiku.
English: Ritonavir Dosing Regimen
Maltese: Disturbi fis-sistema immunitarja tal-ġisem
English: ↑ 2.5-fold
Maltese: ↑b'2.5 drabi
English: Rationale Concomitant medicinal product levels increased or decreased α1-Adrenoreceptor Antagonist
Maltese: Żieda jew tnaqqis fil-livelli tal-prodotti mediċinali li jingħataw b'mod konkomitanti Mediċini li jimblukkaw ir-riċettur 1-Adrenoreceptor
English: Repeated dose toxicity studies in animals identified major target organs as the liver, retina, thyroid gland and kidney.
Maltese: Studji ripetuti dwar tossiċita fil-bhejjem identifikaw bħala l-organi prinċipali li jistgħu jiġu milquta bħala l-fwied, ir-retina, l-glandola tat-tirojde u l-kilwa.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING NORVIR FILM-COATED TABLETS - CARTON WITH BLUE BOX
Maltese: TAGĦRIF LI GĦANDU JIDHER FUQ IL-PAKKETT TA' BARRA NORVIR PILLOLI MIKSIJA B'RITA - KARTUNA BIL-KAXXA BLU
English: ↑ 14 fold
Maltese: TAGĦRIF
English: Patients with advanced HIV disease may be at risk of elevated triglycerides and pancreatitis (see section 4.4).
Maltese: Pazjenti li jbatu mill-marda tal-HIV fi stadju avanzat jistgħu jkunu qegħdin jissugraw trigliċeridi elevati u pankreatite (ara sezzjoni 4.4).
English: Common Insomnia, anxiety, confusion, disturbance in attention, syncope, seizure
Maltese: Nuqqas ta' rqad, ansjeta, konfużjoni, nuqqas t'attenzjoni, sinkope, attakk tal-epilessija
English: Concomitant use of ritonavir dosed as an antiretroviral agent and voriconazole is contraindicated due to reduction in voriconazole concentrations (see section 4.3).
Maltese: L-użu ta' ritonavir dożat bħala aġent antiretrovirali flimkien ma' voriconazole huwa kontro-indikat minħabba tnaqqis fil-konċentrazzjoni ta' voriconazole (ara sezzjoni 4.3).
English: Package leaflet: Information for the user Norvir 100 mg film-coated tablets ritonavir
Maltese: Informazzjoni għall-utent Norvir 100 mg pilloli miksija b'rita ritonavir
English: Antimycobacterial
Maltese: Mediċini Anti-bijotiċi
English: Powder for oral suspension dose
Maltese: Trab għal doża ta' sospensjoni orali
English: ↑ 2.4-fold
Maltese: Amprenavir ↑ bi 2.4 drabi
English: Norvir is used in combination with other anti-HIV medicines (antiretrovirals) to control your HIV infection.
Maltese: Norvir huwa wżat flimkien ma' mediċini oħra għal kontra l-HIV (antiretrovirali) biex jikkontrollalalek l-infezzjoni tal-HIV.
English: Packaged with a mixing cup and two 10 ml calibrated oral dosing syringes.
Maltese: Ippakjati ma' tazza tat-taħlit u żewġ siringi ta' 10 ml għall-dożaġġ orali li huma kalibrati.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of calcium channel antagonists.
Maltese: Ritonavir dożat biex iżid l-effett farmakokinetiku jew bħala aġent antiretrovirali jimpedixxi s- CYP3A4, u għalhekk huwa mistenni li jżid ilkonċentrazzjoni fil-plażma tal-mediċini li jimblukkaw ir-riċetturi tal-kanali tal-kalċju.
English: ↑ 4-fold ↑ 38-fold
Maltese: ↑ bi 38 darba
English: Based on interaction studies with the ritonavir boosted protease inhibitors (lopinavir/ritonavir, atazanavir), concurrent administration of omeprazole or ranitidine does not significantly modify ritonavir efficacy as a pharmacokinetic enhancer despite a slight change of exposure (about 6 - 18%).
Maltese: Skond studji li saru fuq l-interazzjoni mal-impedituri protejaż li huma msaħħa b'ritonavir (lopinavir/ritonavir, atazanavir), l-għoti flimkien ta' omeprazole jew ranitidine, minkejja li jkun hemm bidla żgħira flesponiment (madwar 6 - 18%), ma jbiddilx l-effikaċja ta' ritonavir b'mod sinifikanti.
English: − If Norvir is taken in combination with other antiretroviral medicines, it is important that you also carefully read the leaflets that are provided with these other medicines.
Maltese: - Jekk Norvir jittieħed flimkien ma' mediċini antiretrovirali oħra, huwa importanti li inti taqra b'attenzjoni wkoll il-Fuljett ta' Tagħrif li jkunu pprovduti ma' dawn il-mediċini l-oħra.