FrancophonIA/ELRC3.0 huggingface dataset:
English: Atorvastatin/Emtricitabine
Croatian: atorvastatin/emtricitabin
English: Dihydroartemisinin (active metabolite):
Croatian: dihidroartemisinin (aktivni metabolit): AUC: ↓ 46%
English: Antifungals
Croatian: ANTIKONVULZIVI
English: Carbamazepine/Emtricitabine
Croatian: karbamazepin/emtricitabin
English: Difference between Atripla and original treatment regimen (95%CI)
Croatian: Razlika između Atriple i prvotnog režima liječenja (95% interval pouzdanosti[CI]) bolesnici s HIV-1 RNA < 50 kopija/ml
English: AUC: ↓ 38% (↓ 28 to ↓ 47) Cmax: ↓ 32% (↓ 15 to ↓ 46) Cmin: ↓ 45% (↓ 31 to ↓ 56)
Croatian: AUC: ↓ 38% (↓ 28 do ↓ 47) Cmax: ↓ 32% (↓ 15 do ↓ 46) Cmin: ↓ 45% (↓ 31 do ↓ 56)
English: Co-administration of simeprevir with Atripla is not recommended.
Croatian: Ne preporučuje se istodobna primjena simeprevira s Atriplom.
English: simeprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir.
Croatian: sofosbuvir/velpatasvir/voksilaprev ir
English: Maraviroc/Emtricitabine
Croatian: maravirok/emtricitabin
English: Co-administration of efavirenz with atazanavir/ritonavir is not recommended.
Croatian: Ne preporučuje se istodobna primjena atazanavira/ritonavira s
English: The following side effects are common (these may affect up to 1 in 10 patients)
Croatian: Sljedeće nuspojave su česte (mogu se pojaviti u do 1 na 10 bolesnika)
English: • blurred vision
Croatian: • zamućen vid
English: • tiredness
Croatian: • trnci
English: Atripla and raltegravir can be co-administered without dose adjustment.
Croatian: Atripla i raltegravir mogu se primjenjivati istodobno bez prilagodbe doze.
English: Simvastatin/Tenofovir disoproxil
Croatian: simvastatin/tenofovirdizoproksil
English: Patients with moderate or severe renal impairment require a dose adjustment of emtricitabine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.2 and 5.2).
Croatian: U bolesnika s umjerenim ili teškim oštećenjem funkcije bubrega nužno je prilagođavanje doziranja emtricitabina i tenofovirdizoproksila, što se ne može postići kombiniranom tabletom (vidjeti dio 4.2 i 5.2).
English: Rifabutin/Tenofovir disoproxil
Croatian: rifabutin/tenofovirdizoproksil
English: */100 mg b.i.d./600 mg q.d.)
Croatian: (300 mg b.i.d.*/100 mg b.i.d./600 mg q.d.)
English: Atazanavir/ritonavir/Efavirenz (400 mg q.d./200 mg q.d./600 mg q.d., all administered with food)
Croatian: atazanavir/ritonavir/efavirenz (400 mg q.d./200 mg q.d./600 mg q.d., svi se primjenjuju s hranom)
English: Patients with moderate or severe renal impairment require dose interval adjustment of emtricitabine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.4 and 5.2).
Croatian: U bolesnika s umjerenim ili teškim oštećenjem funkcije bubrega nužno je prilagođavanje intervala doziranja emtricitabina i tenofovirdizoproksila što se ne može postići kombiniranom tabletom (vidjeti dio 4.4 i 5.2).
English: EXP
Croatian: osip
English: Administration to patients with: - a family history of sudden death or of congenital prolongation of the QTc interval on electrocardiograms, or with any other clinical condition known to prolong the QTc interval.
Croatian: Primjena u bolesnika koji imaju: - u obiteljskoj anamnezi iznenadnu smrt ili kongenitalno produljenje QTc intervala na elektrokardiogramu ili neko drugo kliničko stanje za koje je poznato da produljuje QTc interval - anamnezu simptomatskih srčanih aritmija ili klinički značajne bradikardije ili kongestivnog srčanog zatajenja popraćenog smanjenom ejekcijskom frakcijom lijeve klijetke - teške poremećaje ravnoteže elektrolita, npr. hipokalijemiju ili hipomagnezijemiju.
English: Lopinavir/ritonavir/Tenofovir disoproxil (400 mg b.i.d./100 mg b.i.d./245 mg q.d.)
Croatian: lopinavir/ritonavir/ tenofovirdizoproksil mg b.i.d./100 mg b.i.d./245 mg q.d.)
English: AUC: ↑ 22% Cmin: ↑ 37%
Croatian: AUC: ↑ 22%
English: Bristol-Myers Squibb Gyógyszerkereskedelmi Kft. Tel: + 371 67 50 21 85
Croatian: Bristol-Myers Squibb spol. s r.o. Tel: + 386 1 236 47 00
English: AUC: ↓ 58% (↓ 39 to ↓ 68) Cmax: ↓ 51% (↓ 32 to ↓ 58)
Croatian: simvastatin u obliku kiseline: AUC: ↓ 58% (↓ 39 do ↓ 68) Cmax: ↓ 51% (↓ 32 do ↓ 58)
English: AUC: ↓ 83% (↓ 79 to ↓ 87) Cmax: ↓ 80% (↓ 77 to ↓ 83) Cmin: ↓ 86% (↓ 80 to ↓ 90)
Croatian: levonorgestrel (aktivni metabolit): AUC: ↓ 83% (↓ 79 do ↓ 87) Cmax: ↓ 80% (↓ 77 do ↓ 83) Cmin: ↓ 86% (↓ 80 do ↓ 90) (indukcija metabolizma)
English: Buprenorphine/naloxone/Emtricitabine Interaction not studied.
Croatian: lijekovi klase NNRTI / efavirenz Interakcija nije ispitana.
English: Valproic acid/Efavirenz (250 mg b.i.d./600 mg q.d.)
Croatian: valproična kiselina / efavirenz (250 mg b.i.d./600 mg q.d.)
English: Antimycobacterials Rifabutin/Efavirenz (300 mg q.d./600 mg q.d.)
Croatian: Antimikobakterici rifabutin/efavirenz (300 mg q.d./600 mg q.d.)
English: AUC: ↔*/** (↓ 10% to ↑ 26%) Cmax: ↔*/** (↓ 5% to ↑ 26%) Cmin: ↑ 12%*/** (↓ 16 to ↑ 49)
Croatian: AUC: ↔*/** (↓ 10% do ↑ 26%) Cmax: ↔*/** (↓ 5% do ↑ 26%) Cmin: ↑ 12%*/** (↓ 16 do ↑ 49) (indukcija CYP3A4). * U usporedbi s atazanavirom 300 mg/ritonavirom 100 mg q.d. koji se uzima navečer, bez efavirenza.
English: (CYP3A4 or P-gp induction - effect on elbasvir)
Croatian: Cmax: ↓ 45% (indukcija CYP3A4 ili P-gp-a - učinak na elbasvir)
English: Each Atripla film-coated tablet contains 600 mg of efavirenz, 200 mg of emtricitabine and 245 mg of tenofovir disoproxil (as fumarate).
Croatian: Jedna filmom obložena tableta Atriple sadržava 600 mg efavirenza, 200 mg emtricitabina i 245 mg tenofovirdizoproksila (u obliku tenofovirdizoproksilfumarata).
English: Each film-coated tablet contains 600 mg of efavirenz, 200 mg of emtricitabine and 245 mg of tenofovir disoproxil (as fumarate).
Croatian: Jedna filmom obložena tableta sadržava 600 mg efavirenza, 200 mg emtricitabina i 245 mg tenofovirdizoproksila (u obliku tenofovirdizoproksilfumarata).
English: AUC: ↑ 34% (↑ 18 to ↑ 53) Cmax: ↑ 49% (↑ 32 to ↑ 69)
Croatian: klaritromicin 14-hidroksimetabolit: AUC: ↑ 34% (↑ 18 do ↑ 53) Cmax: ↑ 49% (↑ 32 do ↑ 69)
English: Clarithromycin/Efavirenz (500 mg b.i.d./400 mg q.d.)
Croatian: Antibiotici klaritromicin/efavirenz (500 mg b.i.d./400 mg q.d.)
English: Rifampicin/Tenofovir disoproxil (600 mg q.d./245 mg q.d.)
Croatian: rifamicipin/tenofovirdizoproksil (600 mg q.d./245 mg q.d.)
English: Prior PI-based regimen (N=34)
Croatian: Prethodni režim temeljen na inhibitorima proteaze (N=34)
English: Atripla [outer packaging only]
Croatian: 16. PODACI NA BRAILLEOVOM PISMU Atripla [samo vanjsko pakiranje]
English: AUC: ↔ Cmax: ↔ Cmin: ↔
Croatian: paroksetin: AUC: ↔ Cmax: ↔ Cmin: ↔
English: Pravastatin/Emtricitabine
Croatian: pravastatin/emtricitabin
English: 2 This adverse reaction may occur as a consequence of proximal renal tubulopathy.
Croatian: Ova nuspojava može nastati kao posljedica proksimalne bubrežne tubulopatije.
English: Fosamprenavir/ritonavir/Tenofovir disoproxil
Croatian: fosamprenavir/ritonavir/ tenofovirdizoproksil
English: Atazanavir/ritonavir/Efavirenz (400 mg q.d./100 mg q.d./600 mg q.d., all administered with food)
Croatian: atazanavir/ritonavir/efavirenz (400 mg q.d./100 mg q.d./600 mg q.d., svi se primjenjuju s hranom)
English: - Diltiazem or similar medicines (called calcium channel blockers): When you start taking
Croatian: - Diltiazem i slični lijekovi (poznati pod nazivom blokatori kalcijevih kanala): Kada započnete s uzimanjem Atriple, liječnik će Vam možda morati prilagoditi dozu blokatora kalcijevih kanala.
English: Atripla and fluoxetine can be co-administered without dose adjustment.
Croatian: Atripla i fluoksetin mogu se primjenjivati istodobno bez prilagođavanja doze.
English: Patients with moderate or severe renal impairment require dose interval adjustment of emtricitabine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.2 and 4.4).
Croatian: U bolesnika s umjerenim odnosno teškim oštećenjem funkcije bubrega nužno je prilagođavanje intervala doziranja emtricitabina i tenofovirdizoproksila, što se ne može postići kombiniranom tabletom (vidjeti dio 4.2 i 4,4).
English: AUC: ↔ Cmax: ↔
Croatian: emtricitabin: AUC: ↔ Cmax: ↔
English: Due to the similarity between lamivudine and emtricitabine, a component of Atripla, Atripla should not be administered concomitantly with lamivudine (see section 4.4).
Croatian: komponente Atriple, Atripla se ne bi trebala davati istodobno s lamivudinom (vidjeti dio 4.4).
English: • breast enlargement in males
Croatian: • povećanje dojki u muškaraca
English: AUC: ↑ 21% (↑ 10 to ↑ 34) Cmax: ↑ 14% (↑ 4 to ↑ 26) Cmin: ↑ 25% (↑ 7 to ↑ 46)
Croatian: AUC: ↑ 21% (↑ 10 do ↑ 34) Cmax: ↑ 14% (↑ 4 do ↑ 26) Cmin: ↑ 25% (↑ 7 do ↑ 46) (inhibicija oksidativnog metabolizma u kojem sudjeluju enzimi CYP)
English: Your doctor may then conduct blood tests at regular intervals in order to check how well your liver is working (see section 3, If you stop taking Atripla).
Croatian: Vaša jetra radi (pogledajte dio 3, Ako prestanete uzimati Atriplu).
English: Paroxetine/Efavirenz (20 mg q.d./600 mg q.d.)
Croatian: paroksetin/efavirenz (20 mg q.d./600 mg q.d.)
English: Atripla and valproic acid can be co-administered without dose adjustment.
Croatian: Atripla i valproična kiselina mogu se primjenjivati istodobno bez prilagođavanja doze.
English: Atripla and paroxetine can be co-administered without dose adjustment.
Croatian: Atripla i paroksetin mogu se primjenjivati istodobno bez prilagođavanja doze.
English: Dosage adjustments of simvastatin may be required when co-administered with Atripla (refer to the Summary of Product Characteristics for simvastatin).
Croatian: Možda će biti potrebno prilagođavanje doze simvastatina kada se primjenjuje istodobno s Atriplom (pogledajte sažetak opisa svojstava lijeka za simvastatin).
English: Cmax: ↑ 11% (↑ 6 to ↑ 16) Cmin: ↔
Croatian: Cmax: ↑ 11% (↑ 6 do ↑ 16) Cmin: ↔ (indukcija CYP3A4)
English: - The active substances are efavirenz, emtricitabine and tenofovir disoproxil.
Croatian: - Djelatne tvari su efavirenz, emtricitabin i tenofovirdizoproksil.
English: Atovaquone and proguanil hydrochloride/Tenofovir disoproxil
Croatian: atovakvon i progvanil hidroklorid/tenofovirdizoproksil
English: The pharmacokinetics of efavirenz have not been studied in patients with renal impairment.
Croatian: Farmakokinetika efavirenza nije ispitana u bolesnika s oštećenjem funkcije bubrega.
English: Paroxetine/Emtricitabine
Croatian: paroksetin/emtricitabin
English: Voriconazole/Emtricitabine
Croatian: vorikonazol/emtracitibin
English: Cmax: ↑ 15% (CYP3A4 inhibition)
Croatian: AUC: ↑ 21% Cmin: ↑ 17% Cmax: ↑ 15% (inhibicija CYP3A4)
English: Itraconazole/Efavirenz (200 mg b.i.d./600 mg q.d.)
Croatian: Antimikotici itrakonazol/efavirenz (200 mg b.i.d./600 mg q.d.)
English: Atripla (see earlier in section 2, Do not take Atripla).
Croatian: Ako imate tešku bolest jetre, nemojte uzimati Atriplu (pogledajte iznad u poglavlju 2, Nemojte uzimati Atriplu).
English: AUC: ↓ 71% (↓ 67 to ↓ 74) Cmax: ↓ 51% (↓ 46 to ↓ 56) Cmin: ↓ 91% (↓ 88 to ↓ 92)
Croatian: Cmax: ↓ 51% (↓ 46 do ↓ 56) Cmin: ↓ 91% (↓ 88 do ↓ 92)
English: Dosage adjustments of atorvastatin may be required when co-administered with Atripla (refer to the Summary of Product Characteristics for atorvastatin).
Croatian: Možda će biti potrebno podešavanje doze atorvastatina kada se primjenjuje istodobno s Atriplom (pogledajte sažetak opisa svojstava lijeka za atorvastatin).
English: AUC: ↓ 71%
Croatian: norbuprenorfin: AUC: ↓ 71%
English: Didanosine/Tenofovir disoproxil
Croatian: didanozin/tenofovirdizoproksil
English: AUC: ↓ 13% Cmin: ↓ 31% Cmax: ↓ 15%
Croatian: AUC: ↓ 13% Cmin: ↓ 31% Cmax: ↓ 15% (indukcija CYP3A4)
English: Itraconazole/Tenofovir disoproxil
Croatian: itrakonazol/tenofovirdizoproksil
English: Fluoxetine/Emtricitabine
Croatian: fluoksetin/emtricitabin
English: Lopinavir/ritonavir/Emtricitabine
Croatian: fosamprenavir/ritonavir/emtricitab in
English: AUC: ↓ 36% C12h: ↓ 21% Cmax: ↓ 36%
Croatian: AUC: ↓ 36% C12h: ↓ 21% Cmax: ↓ 36% (indukcija UGT1A1)
English: Atripla
Croatian: OPIOIDI
English: Your doctor may need to consider giving you a different antifungal.
Croatian: Liječnik će možda morati razmotriti uvođenje drugog antimikotika.
English: Alternative treatment regimens should be considered for patients with osteoporosis that are at a high risk for fractures.
Croatian: U bolesnika s osteoporozom i visokim rizikom od prijeloma potrebno je razmotriti druge režime liječenja.
English: Bristol-Myers Squibb Gyógyszerkereskedelmi Kft. Tel: + 40 (0) 21 272 16 00
Croatian: Česká republika Bristol-Myers Squibb spol. s r.o. Tel: + 420 221 016 111
English: DMPA/Tenofovir disoproxil
Croatian: DMPA/tenofovirdizoproksil
English: s r.o.
Croatian: V108I
English: AUC: ↓ 39% (↓ 21 to ↓ 53) Cmax: ↓ 37% (↓ 20 to ↓ 51) Cmin: ↓ 44% (↓ 27 to ↓ 58)
Croatian: AUC: ↓ 39% (↓ 21 do ↓ 53) Cmax: ↓ 37% (↓ 20 do ↓ 51) Cmin: ↓ 44% (↓ 27 do ↓ 58) (smanjenje koncentracija itrakozanola: indukcija CYP3A4)
English: General disorders and administration site conditions: Very common asthenia
Croatian: Opći poremećaji i reakcije na mjestu primjene: Vrlo često astenija
English: Saquinavir/ritonavir/Tenofovir disoproxil There were no clinically significant pharmacokinetic interactions when tenofovir disoproxil was co-administered with ritonavir boosted saquinavir.
Croatian: Nije bilo klinički značajnih farmakokinetičkih interakcija kada je tenofovirdizoproksil primjenjivan istodobno sa sakvinavirom ojačanim ritonavirom. sakvinavir/ritonavir/emtricitabin Interakcija nije ispitana.
English: AUC: ↓ 60% (↓ 52 to ↓ 68) Cmax: ↓ 62% (↓ 55 to ↓ 78)
Croatian: AUC: ↓ 60% (↓ 52 do ↓ 68) Cmax: ↓ 62% (↓ 55 do ↓ 78) (indukcija CYP3A4)
English: The pharmacokinetics of Atripla have not been studied in patients with hepatic impairment.
Croatian: Farmakokinetika Atriple nije ispitana u bolesnika s oštećenjem funkcije jetre.
English: Cmax: ↓ 28% (↓ 7 to ↓ 44) Cmin: ↓ 37% (↓ 17 to ↓ 52)
Croatian: AUC: ↓ 37% (↓ 17 do ↓ 52) Cmax: ↓ 28% (↓ 7 do ↓ 44) Cmin: ↓ 37% (↓ 17 do ↓ 52)
English: AUC: ↓ 52% (↓ 33 to ↓ 66) Cmax: ↓ 45% (↓ 25 to ↓ 59)
Croatian: AUC: ↓ 52% (↓ 33 do ↓ 66) Cmax: ↓ 45% (↓ 25 do ↓ 59) (indukcija CYP3A4)
English: AUC: ↓ 26% (↓ 15 to ↓ 36) Cmax: ↓ 20% (↓ 11 to ↓ 28) Cmin: ↓ 32% (↓ 15 to ↓ 46)
Croatian: AUC: ↓ 26% (↓ 15 do ↓ 36) Cmax: ↓ 20% (↓ 11 do ↓ 28) Cmin: ↓ 32% (↓ 15 do ↓ 46) (indukcija CYP3A4 i CYP2B6)
English: DMPA/Emtricitabine
Croatian: DMPA/emtricitabin
English: Sertraline/Tenofovir disoproxil
Croatian: sertralin/tenofovirdizoproksil
English: Your doctor may conduct blood tests in order to check how well your liver is working or may switch you to another medicine.
Croatian: Vaša jetra radi ili Vam može propisati drugi lijek.
English: Physicians should refer to current HIV treatment guidelines for the optimal management of HIV infection in patients co-infected with HBV.
Croatian: U cilju optimalnog liječenja infekcije HIV-om u bolesnika koji su istodobno zaraženi virusom HBV-a, liječnici se trebaju pridržavati trenutno važećih smjernica za liječenje HIV-a.
English: Atripla and rosuvastatin can be co-administered without dose adjustment.
Croatian: Atripla i rosuvastatin mogu se primjenjivati istodobno bez prilagodbe doze.
English: Lopinavir/ritonavir tablets/Efavirenz (400/100 mg b.i.d./600 mg q.d.)
Croatian: lopinavir/ritonavir meke kapsule ili oralna otopina/ efavirenz tablete lopinavira/ritonavira / efavirenz (400/100 mg b.i.d./600 mg q.d.)
English: Carbamazepine/Tenofovir disoproxil
Croatian: karbamazepin/tenofovirdizoproksi l
English: AUC: ↓ 64% (↓ 62 to ↓ 67) Cmax: ↓ 46% (↓ 39 to ↓ 52) Cmin: ↓ 82% (↓ 79 to ↓ 85)
Croatian: norelgestromin (aktivni metabolit): AUC: ↓ 64% (↓ 62 do ↓ 67) Cmax: ↓ 46% (↓ 39 do ↓ 52) Cmin: ↓ 82% (↓ 79 do ↓ 85)
English: Paroxetine/Tenofovir disoproxil
Croatian: paroksetin/tenofovirdizoproksil
English: Ritonavir/Tenofovir disoproxil
Croatian: ritonavir/tenofovirdizoproksil
English: */100 mg b.i.d./245 mg q.d.)
Croatian: (600 mg/200 mg/245 mg q.d.)
English: Mechanism of action and pharmacodynamic effects Efavirenz is an NNRTI of HIV-1.
Croatian: Efavirenz je nenukleozidni inhibitor reverzne transkriptaze (NNRTI) virusa HIV-1.
English: Atazanavir/ritonavir/Tenofovir disoproxil (300 mg q.d./100 mg q.d./245 mg q.d.)
Croatian: Antivirusni lijekovi protiv HIV-a Inhibitori proteaze atazanavir/ritonavir/ tenofovirdizoproksil (300 mg q.d./100 mg q.d./245 mg q.d.)
English: Diltiazem/Tenofovir disoproxil
Croatian: diltiazem/tenofovirdizoproksil
English: Dosage adjustments of pravastatin may be required when co-administered with Atripla (refer to the Summary of Product Characteristics for pravastatin).
Croatian: Možda će biti potrebno podešavanje doze pravastatina kada se primjenjuje istodobno s Atriplom (pogledajte sažetak opisa svojstava lijeka za pravastatin).
English: The following side effects may be signs of lactic acidosis: - deep rapid breathing - drowsiness - feeling sick (nausea), being sick (vomiting) and stomach pain.
Croatian: duboko, brzo disanje omamljenost mučnina, povraćanje i bol u želucu.
English: ANTICONVULSANTS Carbamazepine/Efavirenz (400 mg q.d./600 mg q.d.)
Croatian: karbamazepin/efavirenz (400 mg q.d./600 mg q.d.)
English: AUC: ↓ 83% Cmax: ↓ 87%
Croatian: Cmax: ↓ 87%
English: Dosage adjustment of lopinavir/ritonavir is necessary when given with efavirenz.
Croatian: Kada se primjenjuje zajedno s efavirenzom, nužno je podešavanje doze lopinavira/ritonavira.
English: Fluoxetine/Tenofovir disoproxil
Croatian: fluoksetin/tenofovirdizoproksil
English: AUC: ↓ 21% Cmax: ↔
Croatian: lumefantrin: AUC: ↓ 21% Cmax: ↔
English: Symptoms including, but not limited to, dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming are frequently reported undesirable effects in patients receiving efavirenz 600 mg daily in clinical studies.
Croatian: U bolesnika koji su tijekom kliničkih ispitivanja primali 600 mg efavirenza dnevno često su uočene nuspojave koje između ostalog uključuju omaglicu, nesanicu, somnolenciju, smanjenu koncentraciju i abnormalne snove.
English: However, dizziness has been reported during treatment with efavirenz, emtricitabine and tenofovir disoproxil.
Croatian: No tijekom liječenja efavirenzom, emtricitabinom i tenofovirdizoproksilom zabilježeni su slučajevi omaglice.
English: AUC: ↔ Cmin: ↔
Croatian: Cmax: ↔ Cmin: ↔
English: Bristol-Myers Squibb Gyógyszerkereskedelmi Kft. Tel: + 370 5 2790 762
Croatian: Slovenská republika Bristol-Myers Squibb spol. s r.o. Tel: + 421 2 59298411
English: Sofosbuvir/Velpatasvir/Voxilaprevir (400 mg/100 mg/100 mg q.d.)
Croatian: sofosbuvir/velpatasvir (400 mg/100 mg q.d.) + efavirenz/emtricitabin/ tenofovirdizoproksil (600 mg/200 mg/245 mg q.d.)
English: Cmax: ↓ 64% (↓ 57 to ↓ 69) Cmin: ↓ 62% (↓ 44 to ↓ 75)
Croatian: AUC: ↓ 75% (↓ 59 do ↓ 84) Cmax: ↓ 64% (↓ 57 do ↓ 69) Cmin: ↓ 62% (↓ 44 do ↓ 75)
English: Bupropion/Tenofovir disoproxil
Croatian: Bupropion/tenofovirdizoproksil
English: N-monodesmethyl diltiazem: AUC: ↓ 37% (↓ 17 to ↓ 52)
Croatian: simeprevir: AUC: ↓ 71% (↓ 67 do ↓ 74)
English: Gilead Sciences Netherlands B.V. Tel: + 31 (0) 20 718 36 98
Croatian: Tel: + 31 (0) 20 718 36 98
English: AUC: ↓ 50% Cmax: ↓ 45%
Croatian: AUC: ↓ 50% Cmax: ↓ 45% (indukcija UDP-G)
English: Co-administration of lopinavir/ritonavir and Atripla is not recommended.
Croatian: Ne preporučuje se istodobna primjena lopinavira/ritonavira s
English: PHARMACEUTICAL FORM AND CONTENTS
Croatian: Drugi lijekovi i Atripla
English: Atorvastatin/Tenofovir disoproxil
Croatian: pravastatin/tenofovirdizoproksil
English: Your doctor may consider giving you the components of Atripla separately if you are having problems or need your dose adjusted.
Croatian: Ako ste imali problema ili je potrebno prilagođavanje Vaše doze, liječnik će možda razmotriti zasebno davanje komponenti Atriple.
English: simvastatin.
Croatian: Atriplom.
English: Ledipasvir/Sofosbuvir (90 mg/400 mg q.d.)
Croatian: ledipasvir/sofosbuvir (90 mg/400 mg q.d.) + efavirenz/emtricitabin/ tenofovirdizoproksil
English: Dose adjustment of buprenorphine may not be necessary when co-administered with Atripla.
Croatian: Kada se buprenorfin primjenjuje istodobno s Atriplom, prilagođavanje doze buprenorfina možda neće biti potrebno.
English: Emtricitabine
Croatian: OBLIK
English: Keep the tablet bottle with you so that you can easily describe what you have taken.
Croatian: Ponesite bocu s tabletama sa sobom tako da možete lako opisati što ste uzeli.
English: Do not give this medicine to children under 12 years of age.
Croatian: Nemojte davati ovaj lijek djeci u dobi ispod 12 godina.
English: The recommended dose is one tablet once a day.
Croatian: Preporučena doza je jedna tableta jedanput na dan.
English: It also contains lactose.
Croatian: Također sadrži laktozu.
English: The clinical significance of this substitution is currently unknown.
Croatian: Klinička značajnost ove supstitucije trenutačno nije poznata.
English: Ask your doctor for effective contraceptive method suitable for you.
Croatian: Upitajte liječnika koja je učinkovita metoda kontracepcije pogodna za Vas.
English: • If you are currently taking any of the following medicines:
Croatian: • ako trenutno uzimate neki od sljedećih lijekova:
English: Summary of the safety profile in adults
Croatian: Sažetak sigurnosnog profila u odraslih
English: • The other ingredients are
Croatian: • Drugi sastojci su
English: The effects of higher doses are not known.
Croatian: Učinci viših doza nisu poznati.
English: < 12 g/dL despite 4 weeks at reduced dose
Croatian: < 12 g/dl unatoč 4 tjedna na sniženoj dozi
English: The most common variant was Y93H.
Croatian: Najčešća varijanta bila je Y93H.
English: • other liver problems apart from hepatitis C, for instance
Croatian: • druge tegobe s jetrom osim hepatitisa C, na primjer:
English: • you have diabetes.
Croatian: • imate šećernu bolest.
English: > or = 75
Croatian: > ili = 75
English: SVR12 was achieved in 18/18 patients.
Croatian: SVR12 je postignut u 18/18 bolesnika.
English: Ledipasvir is > 99.8% bound to human plasma proteins.
Croatian: Ledipasvir je > 99,8 % vezan za proteine ljudske plazme.
English: The tablet is 19 mm long and 10 mm wide.
Croatian: Tableta je dugačka 19 mm i široka 10 mm.
English:  If this applies to you, do not take Harvoni and tell your doctor immediately.
Croatian: Ako se ovo odnosi na Vas, nemojte uzimati Harvoni i odmah obavijestite svog liječnika.
English: Effects of food
Croatian: Utjecaj hrane
English: Do not chew, crush or split the tablet as it has a very bitter taste.
Croatian: Nemojte žvakati, drobiti niti lomiti tabletu, jer je vrlo gorkog okusa.
English: AUC, Cmax, Cmina, b
Croatian: Cmax, Cmina,b
English: • Your doctor can decide if you should take Harvoni and for how long;
Croatian: • Vaš liječnik može odlučiti trebate li uzimati Harvoni i koliko dugo;
English: Patients should be instructed not to take a double dose.
Croatian: Bolesnicima treba savjetovati da ne uzimaju dvostruku dozu.
English: Ribavirin was discontinued in 15% of the patients.
Croatian: Primjena ribavirina bila je obustavljena u 15 % bolesnika.
English: 1.6-fold↑
Croatian: 1,6 puta↑
English: What Harvoni is and what it is used for
Croatian: Što je Harvoni i za što se koristi
English: The majority of patients (84%) had been infected through vertical transmission.
Croatian: Većina bolesnika (84 %) bila je zaražena vertikalnim prijenosom bolesti.
English: Ribavirin can be very damaging to an unborn baby.
Croatian: Ribavirin može izazvati teška oštećenja kod nerođenog djeteta.
English: Race: Black/ African
Croatian: Rasa: Crnci/ Afroamerikanci
English: e These are drugs within class where similar interactions could be predicted.
Croatian: Ovo su lijekovi iz iste klase za koje se mogu predvidjeti slične interakcije.
English: Treatment duration was fixed in each study.
Croatian: Trajanje liječenja bilo je fiksno u svakom ispitivanju.
English: Stable replicons
Croatian: Stabilni replikoni
English: Treatment and duration
Croatian: Liječenje i trajanje
English: These medicines can decrease the amount of ledipasvir in your blood.
Croatian: Ovi lijekovi mogu smanjiti količinu ledipasvira u Vašoj krvi.
English: The active metabolite is not observed.
Croatian: Aktivni metabolit nije opažen.
English: Like all medicines, this medicine may cause side effects.
Croatian: Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave.