FrancophonIA/ELRC3.0 huggingface dataset:
English: Some patients have experienced the following side effects during clinical studies while taking sitagliptin alone (one of the medicines in Efficib) or during post-approval use of Efficib or sitagliptin alone or with other diabetes medicines:
Croatian: Neki bolesnici koji su u kliničkim ispitivanjima uzimali samo sitagliptin (jednu od djelatnih tvari lijeka Efficib), kao i bolesnici koji su koristili Efficib ili sitagliptin, nakon njihova stavljanja u promet, same ili s drugim lijekovima za šećernu bolest, imali su sljedeće nuspojave: Često: nizak šećer u krvi, glavobolja, infekcija gornjih dišnih puteva, začepljen nos ili curenje iz nosa i grlobolja, osteoartritis, bolovi u rukama ili nogama Manje često: omaglica, zatvor, svrbež
English: In case of long term treatment (more than 6 months):
Croatian: U slučaju dugotrajnog liječenja (dulje od 6 mjeseci):
English: • Allergic reactions which can, rarely, be serious
Croatian: • alergijske reakcije koje u rijetkim slučajevima mogu biti ozbiljne
English: All symptoms resolved completely within a few hours.
Croatian: Svi su se simptomi za nekoliko sati u potpunosti povukli.
English: Response rates varied between 43 and 80% depending on the studies and the criteria to define a response.
Croatian: Stopa odgovora bila je između 43 i 80%, ovisno o studiji i kriterijima kojima se definira odgovor.
English: Careful monitoring.
Croatian: Pažljivo praćenje.
English: • Intolerance to alcohol
Croatian: • intolerancija na alkohol
English: Not recommended unless necessary.
Croatian: Ne preporučuje se osim ako je neophodno.
English: Effects on human reproduction cannot be excluded.
Croatian: Ne može se isključiti utjecaj na humanu reprodukciju.
English: Escape phenomenon
Croatian: Fenomen bijega
English: • Loss of appetite or increased appetite
Croatian: • gubitak apetita ili povećan apetit
English: Currently available data are described in sections 4.8, 5.1 and 5.2 but no recommendation on a posology can be made.
Croatian: Trenutno dostupni podaci opisani su u dijelovima 4.8, 5.1 i 5.2, no ne mogu se dati preporuke za doziranje.
English: If you forget to take one dose, take this dose as soon as you remember.
Croatian: Ako zaboravite uzeti jednu dozu, uzmite je čim se sjetite.
English: Cmax and AUC increase more than proportionally with dose.
Croatian: Cmax i AUC povećavaju se više od proporcionalnog povećanja s dozom.
English: • Change in laboratory markers
Croatian: • promjena laboratorijskih markera
English: There are no data suggesting a need for a specific dose adjustment in this population.
Croatian: Nema podataka koji bi ukazivali na potrebu posebne prilagodbe doze u ovoj populaciji.
English: Then go on with regular schedule as prescribed.
Croatian: Zatim lijek nastavite uzimati prema uobičajenom rasporedu kako je propisano.
English: About 200 patients were treated for more than 6 months and some of them were treated for several years.
Croatian: Oko 200 bolesnika liječeno je dulje od 6 mjeseci, a neki su liječeni i nekoliko godina.
English: Plasma elimination is biphasic with a half-life of 2 hours during the first 10 hours and 8 hours thereafter.
Croatian: Eliminacija iz plazme je bifazična s poluvijekom od 2 sata tijekom prvih 10 sati i 8 sati nakon toga.
English: Associated with a decrease in corresponding values for the active metabolite
Croatian: Povezan sa smanjenjem odgovarajućih vrijednosti za aktivni metabolit
English: About 13% of the dose is excreted in the urine, of which 2 to 4% is unchanged medicinal product.
Croatian: Oko 13 % doze izlučuje se urinom, od čega 2 do 4 % kao nepromijenjen lijek.
English: This medicine is not recommended for children under 12 years due to the lack of data in these patients.
Croatian: Ovaj lijek ne preporučuje se za djecu mlađu od 12 godina zbog nedostatnih podataka o primjeni lijeka u ovih bolesnika.
English: Tell your doctor or phamacist if you are taking, have recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
English: Frequency of hepatotoxicity could be higher in adolescents than in adults.
Croatian: Učestalost hepatotoksičnosti mogla bi biti viša u adolescenata nego u odraslih.
English: Do not take this medicinal product during pregnancy.
Croatian: Ovaj lijek se ne smije uzimati u trudnoći.
English: Dose reduction of indinavir to 600 mg every 8 hours should be considered.
Croatian: Treba razmotriti smanjenje doze indinavira na 600 mg svakih 8 sati.
English: In a retrospective study conducted in several French centres, 200 patients with Cushing's disease were followed between 1995 and 2012.
Croatian: U retrospektivnoj studiji provedenoj u nekoliko francuskih centara od 1995. do 2012. godine praćeno je 200 bolesnika s Cushingovom bolesti.
English: • Distortion of the sense of taste
Croatian: • poremećen osjećaj okusa
English: Women must be provided with comprehensive information on pregnancy prevention.
Croatian: Ženama moraju biti pružene sveobuhvatne informacije o sprječavanju začeća.
English: Centre Spécialités Pharmaceutiques 76-78 avenue du Midi 63800 Courron d‘Auvergne France
Croatian: Centre Spécialités Pharmaceutiques 76-78 avenue du Midi 63800 Courron d‘Auvergne Francuska ili
English: This can result in an increase and/or prolongation of their effects, including adverse reactions.
Croatian: Posljedica toga može biti povećanje i/ili produljenje njihova učinka, uključujući nuspojave.
English: In vitro, the plasma protein binding is about 99% mainly to the albumin fraction.
Croatian: In vitro, vezanje na proteine u plazmi iznosi približno 99 %, uglavnom na albuminsku frakciju.
English: If you think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Croatian: Ako mislite da ste trudni ili planirate zatrudnjeti, obratite se svom liječniku za savjet prije nego što uzmete ovaj lijek.
English: An ECG should be performed:
Croatian: EKG treba obaviti:
English: The maximal dose that was used for treatment of Cushing's syndrome is 1,600 mg/day.
Croatian: Maksimalna doza korištena za liječenje Cushingovog sindroma iznosi 1600 mg/dan.
English: Frequency groupings are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known:
Croatian: Skupine učestalosti definirane su prema sljedećoj konvenciji: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Use in Cushing's disease
Croatian: Uporaba kod Cushingove bolesti
English: Hepatotoxicity does not appear to be dose dependent.
Croatian: Čini se da hepatotoksičnost ne ovisi o dozi.
English: Alcohol intolerance, anorexia, increased appetite
Croatian: Intolerancija na alkohol, anoreksija, pojačan apetit
English: Treatment of juvenile rats for 30 day beginning at 21 days of age delayed the puberty onset.
Croatian: Liječenje mladih štakora tijekom 30 dana od 21. dana života uzrokovalo je odgodu pojave puberteta.
English: Bone fragility and broken legs were reported in rats but were not observed in other species.
Croatian: Slučajevi lomljivih kosti i prijeloma nogu prijavljeni su u štakora, no nisu primijećeni u drugih vrsta.
English: The safety and efficacy of Ketoconazole HRA in children aged less than 12 years have not been established.
Croatian: Sigurnost i djelotvornost Ketoconazolea HRA u djece mlađe od 12 godina nisu ustanovljene.
English: However no modifications of ECG were recorded in dogs at daily doses up to 40 mg/kg administered for 12 months.
Croatian: Međutim, nisu zabilježene promjene na EKG-a u pasa pri dnevnim dozama do 40 mg/kg primjenjivanim tijekom 12 mjeseci.
English: HRA Pharma Rare Diseases 200 avenue de Paris 92320 CHATILLON France
Croatian: HRA Pharma Rare Diseases 200 avenue de Paris 92320 CHATILLON Francuska
English: Ketoconazole was stopped, but she deteriorated rapidly and died.
Croatian: Ketokonazol je ukinut, no njezino se stanje rapidno pogoršavalo te je umrla.
English: Aripiprazole dose should be reduced to approximatively one-half of its prescribed dose.
Croatian: Dozu aripiprazola treba smanjiti na približno upola manju od propisane.
English: The requirements for submission of PSURsfor this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Croatian: Zahtjevi za podnošenje PSUR-eva za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim sljedećim ažuriranim verzijama objavljenima na europskom internetskom portalu za lijekove.
English: Careful monitoring as it may cause an earlier onset and/or an increased severity of side-effects.
Croatian: Pažljivo praćenje jer mogu uzrokovati raniju pojavu i/ili veću težinu nuspojava.
English: • Aversion to light
Croatian: • odbojnost prema svjetlu
English: Speak with your doctor if you have a history of liver disease.
Croatian: Obavijestite liječnika ako imate bolest jetre u povijesti bolesti.
English: Alfentanil, fentanyl
Croatian: Alfentanil, fentanil
English: Use in ectopic Adrenocorticotropic Hormone (ACTH) syndrome
Croatian: Uporaba kod ektopičnog sindroma adrenokortikotropnog hormona (ACTH)
English: Side effects with frequency not known (frequency cannot be estimated from the available data):
Croatian: Nuspojave čija je učestalost nepoznata (učestalost se ne može procijeniti iz dostupnih podataka):
English: Careful monitoring of digoxin levels is recommended.
Croatian: Preporučuje se pažljivo praćenje razina digoksina.
English: Table 2: Incidence of adverse reactions and marked laboratory abnormalities reported in the literature in adults and adolescents patients
Croatian: Tablica 2: Incidencija nuspojava i značajnih laboratorijskih abnormalnosti objavljenih u literaturi u odraslih i adolescentnih bolesnika
English: Nevirapine: plasma levels: ↑1.15-1.28fold compared to historical controls
Croatian: Nevirapin: plazmatske razine: ↑ 1,151,28 puta u usporedbi s povijesnim kontrolama
English: Serious hepatic toxicity caused by ketoconazole treatment is rare (1/15000).
Croatian: Ozbiljna oštećenja jetre uzrokovana ketokonazolom su rijetka (1/15 000).
English: In approximately 10 to 15 % of ketoconazole treated patients, an "escape phenomenon" is observed and reinforces the need for a long-term clinical and biochemical follow-up of these patients.
Croatian: U približno 10 % do 15 % bolesnika liječenih ketokonazolom uočen je „fenomen bijega” koji zahtijeva dugotrajno kliničko i biokemijsko praćenje tih bolesnika.
English: Increases in liver enzymes (≤ 5N and > 5N) were observed in ~13.5 % and ~2.5% of patients respectively occurring mostly within the first 6 months of treatment.
Croatian: Povišene vrijednosti jetrenih enzima (≤ 5N i > 5N) uočene su u ~13,5 % odnosno ~2,5 % bolesnika, najčešće unutar prvih 6 mjeseci liječenja.
English: Insomnia, nervousness
Croatian: Nesanica, nervoza
English: Maraviroc dose should be decreased to 150 mg twice daily.
Croatian: Dozu maraviroka treba smanjiti na 150 mg dvaput na dan.
English: Studies in animals have shown effects on male and female reproductive parameters (see section 5.3).
Croatian: Ispitivanja na životinjama pokazala su učinke na muške i ženske reproduktivne parametre (vidjeti dio 5.3).
English: If these occur, treatment should be stopped immediately and liver function tests should be performed.
Croatian: Ako se ovi simptomi pojave, treba odmah prekinuti liječenje i provesti pretrage funkcije jetre.
English: Beta Blockers Nadolol
Croatian: Beta-blokatori Nadolol
English: In the event of accidental overdose, treatment consists of supportive measures.
Croatian: U slučaju nenamjernog predoziranja liječenje se sastoji od potpornih mjera.
English: Careful monitoring INR (international normalised ratio) monitoring recommended.
Croatian: Preporučuje se praćenje INR-a (međunarodnog normaliziranog omjera).
English: Careful monitoring of adverse reactions (respiratory depression, sedation) is recommended.
Croatian: Preporučuje se pažljivo praćenje nuspojava (respiratorne depresije, sedacije).
English: Block and replace regimen
Croatian: Režim liječenja blokadom i nadomještanjem
English: Data on the use of ketoconazole in patients older than 65 years are limited, but there is no evidence to suggest that specific dose adjustment is required in these patients (see section 5.2).
Croatian: Podaci o primjeni ketokonazola u bolesnika starijih od 65 godina su ograničeni, ali nema dokaza koji bi ukazivali na to da je kod tih bolesnika potrebno posebno prilagođavanje doze (vidjeti dio 5.2).
English: - Prior to the start of ketoconazole - Within one week after the beginning of the treatment - As clinically indicated thereafter.
Croatian: - prije početka primjene ketokonazola - unutar tjedan dana nakon početka liječenja - nakon toga prema kliničkoj indikaciji.
English: • Erectile dysfunction
Croatian: • erektilna disfunkcija
English: At the last visit, 78 patients (49.3%) were controlled, 37 patients (23.4%) had partial control with at least 50% decrease of UFC (without normalisation), and 43 patients (27.2%) had unchanged UFC levels.
Croatian: Na posljednjem posjetu u 78 je bolesnika (49,3 %) postignuta kontrola bolesti, u 37 bolesnika (23,4 %) djelomična kontrola sa smanjenjem UFC-a za najmanje 50 % (bez normalizacije), a u 43 bolesnika (27,2 %) razine UFC-a bile su nepromijenjene.
English: Transient decrease of testosterone concentrations
Croatian: Prolazno smanjenje koncentracija testosterona
English: At doses > 400 mg/day, half-lives of 3 to 10 hours have been reported.
Croatian: Pri dozama > 400 mg/dan prijavljen je poluvijek od 3 do 10 sati.
English: Ketoconazole is not carcinogenic.
Croatian: Ketokonazol nije karcinogen.
English: No studies were performed with albumin bound nanoparticules.
Croatian: Nisu provedena ispitivanja s nanočesticama vezanim na albumin.
English: However, the genotoxic potential was not properly determined for the proposed dosing regimen in the treatment of endogenous Cushing's syndrome.
Croatian: Međutim, genotoksični potencijal nije u potpunosti utvrđen za predviđeni režim doziranja u liječenju endogenog Cushingovog sindroma.
English: The major identified metabolic pathways are oxidation and degradation of the imidazole and piperazine rings, oxidative O-dealkylation and aromatic hydroxylation.
Croatian: Glavni identificirani metabolički putevi su oksidacija i degradacija imidazolnih i piperazinskih prstenova, oksidativna O-dealkilacija i aromatska hidroksilacija.
English: Table 1 Interactions and recommendations for co-administration.
Croatian: Tablica 1:Interakcije i preporuke za istovremenu primjenu
English: Potential interaction with medicinal products
Croatian: Potencijalne interakcije s drugim lijekovima
English: Data of inhibition indicate that risk of interaction with BCRP substrates cannot be excluded at the systemic level with very high doses of ketoconazole.
Croatian: Podaci o inhibiciji ukazuju na to da se rizik od interakcije sa supstratima BCRP-a ne može isključiti na sistemskoj razini pri vrlo visokim dozama ketokonazola.
English: If such a phenomenon occurs, a further dose increase may be required to maintain cortisol levels within the normal range.
Croatian: Ako se ovaj fenomen pojavi, možda će biti potrebno dodatno povećati dozu radi održavanja normalnih razina kortizola.
English: Initiation and follow up of the treatment must be supervised by specialists in endocrinology.
Croatian: Liječenje moraju započeti i pratiti liječnici specijalisti endokrinologije.
English: Fatal cases have been reported particularly when treatment is continued despite liver enzyme elevation.
Croatian: Smrtni ishodi prijavljeni su u slučajevima kada je liječenje nastavljeno usprkos povišenim vrijednostima jetrenih enzima.
English: Indinavir (600mg TID): AUC= 0.8-fold
Croatian: Indinavir (600 mg triput na dan): AUC= 0,8 puta
English: • Sensation of tingling or pricking
Croatian: • osjećaj trnaca ili bockanja
English: Specific dosing regimen
Croatian: Posebni režim doziranja
English: Monitoring of QT-prolongation if used concomitantly.
Croatian: Praćenje produljenja QT intervala ako se uzima istovremeno.
English: Ask your doctor or pharmacist for more information if you are taking Ketoconazole HRA with other medicines.
Croatian: Upitajte liječnika ili ljekarnika za više informacija ako Ketoconazole HRA uzimate s drugim lijekovima.
English: Not recommended as it may increase ibrutinib-related toxicity.
Croatian: Ne preporučuje se jer može povećati toksičnost povezanu s ibrutinibom.
English: Close surveillance will be necessary: blood pressure and fluid and electrolyte balance should be monitored for a few days.
Croatian: Bolesnika treba pomno pratiti: nekoliko dana treba pratiti krvni tlak te ravnotežu tekućine i elektrolita.
English: The doses used in adolescents above 12 years old were similar to the doses used in adults' patients with endogenous Cushing's syndrome.
Croatian: Doze u adolescenata starijih od 12 godina bile su slične dozama korištenim u odraslih bolesnika s endogenim Cushingovim sindromom.
English: Patients with congenital lactase deficiency, galactosaemia or glucose-galactose intolerance must not be given this medicine unless strictly necessary.
Croatian: Bolesnici s urođenim nedostatkom laktaze, galaktosemijom ili intolerancijom na glukozu-galaktozu ne bi smjeli uzimati ovaj lijek osim ako je strogo neophodno.
English: There is no evidence to suggest that there is an interaction between ketoconazole and other steroidogenesis inhibitors (i.e. metyrapone).
Croatian: Nema dokaza koji bi ukazivali na interakcije između ketokonazola i drugih inhibitora steroidogeneze (primjerice metirapona).
English: Monitoring of the QTc interval
Croatian: Praćenje QTc intervala
English: At the last follow-up, clinical signs were improved in 74/134 patients (55.2%), hypertension in 36/90 patients (40), hypokalaemia in 10/26 patients (38.4%), and diabetes mellitus in 23/39 patients (59%).
Croatian: Na zadnjem kontrolnom posjetu klinički znakovi poboljšali su se u 74/134 bolesnika (55,2 %), hipertenzija u 36/90 bolesnika (40), hipokalijemija u 10/26 bolesnika (38,4 %), a dijabetes melitus u 23/39 bolesnika (59 %).
English: Ketoconazole is extensively metabolised to a large number of inactive metabolites.
Croatian: Ketokonazol se u velikoj mjeri metabolizira u velik broj inaktivnih metabolita.
English: Ketoconazole has been used both as sole medical therapy and in combination with other medicinal products, mainly with metyrapone, in patients with more severe disease or in those not completely responding to a single active substance or in those requiring a dose reduction of at least one of the medicinal products to improve tolerance.
Croatian: Ketokonazol se upotrebljava i kao samostalan lijek i u kombinaciji s drugim lijekovima, prvenstveno metiraponom, u bolesnika s težom bolesti, ili onih koji nemaju potpuni odgovor na samo jednu djelatnu tvar ili u bolesnika kod kojih je potrebno smanjiti dozu najmanje jednog lijeka radi poboljšanja podnošljivosti.
English: Not recommended due to an increased bleeding risk.
Croatian: Ne preporučuje se zbog povećanog rizika od krvarenja.
English: Activated charcoal may be given if considered appropriate.
Croatian: Ako se smatra prikladnim, može se dati i aktivni ugljen.
English: The adverse reactions listed below in table 2 are classified according to System Organ Class.
Croatian: Nuspojave navedene u nastavku u Tablici 2 kategorizirane su prema klasifikaciji organskih sustava.
English: Heart disease Ketoconazole HRA can change how your heart beats - this can be serious.
Croatian: Ketoconazole HRA može promijeniti otkucaje Vašeg srca - to može biti ozbiljno.
English: The major route of excretion is through the bile into the intestinal tract.
Croatian: Glavni put eliminacije putem žuči vodi u intestinalni trakt.
English: Vardenafil is contraindicated in men older than 75 years old (see section
Croatian: Vardenafil je kontraindiciran u muškaraca starijih od 75 godina (vidjeti dio 4.3).
English: Use with hepatotoxic medicinal products
Croatian: Uporaba s hepatotoksičnim lijekovima
English: The half-life of ketoconazole increases with dose and duration of treatment.
Croatian: Poluvijek ketokonazola povećava se s dozom i trajanjem liječenja.
English: Do not take Ketoconazole HRA if any of the above applies to you.
Croatian: Nemojte uzimati Ketoconazole HRA ako se nešto od navedenog odnosi na Vas.
English: Inhibition of these different transporters at clinically relevant concentrations of ketoconazole cannot be excluded.
Croatian: Inhibicija tih različitih prijenosnika pri klinički značajnim koncentracijama ketokonazola ne može se isključiti.
English: Although hepatotoxicity is usually observed at treatment initiation and within the first six months of treatment, monitoring of liver enzymes should be done under medical criteria.
Croatian: Iako se hepatotoksičnost obično očituje na početku liječenja i unutar prvih šest mjeseci liječenja, jetrene enzime valja pratiti u skladu s medicinskim kriterijima.
English: Use of ketoconazole with potent enzyme inducers is not recommended.
Croatian: Primjena ketokonazola sa snažnim induktorima enzima se ne preporučuje.
English: However in patients with adrenal cortical carcinoma, improvement of hypercortisolism on ketoconazole was limited in some cases.
Croatian: Međutim, u bolesnika s adrenokortikalnim karcinomom poboljšanje hiperkortikolizma tijekom liječenja ketokonazolom bilo je u nekim slučajevima ograničeno.
English: • Transient decrease of testosterone, a male hormone (androgen) made by the body,
Croatian: • prolazno smanjenje razina testosterona, muškog hormona (androgena) koji proizvodi tijelo, uglavnom u testisima
English: The dose will be adapted to your condition with the aim to restore normal cortisol levels.
Croatian: Prilagodit će dozu Vašem stanju kako bi se ponovno uspostavile normalne razine kortizola.
English: Liver enzyme levels returned to normal within 2-12 weeks after a dose decrease or withdrawal of ketoconazole.
Croatian: Razine jetrenih enzima normalizirale su se unutar 2-12 tjedana nakon smanjenja doze ili nakon prestanka primjene ketokonazola.
English: Doses of 80 and 160 mg/kg inhibited ovulation in immature rats.
Croatian: Doze od 80 i 160 mg/kg inhibirale su ovulaciju u nezrelih štakora.
English: Potential ↑in AUC of risperidone:
Croatian: Potencijalno ↑ AUC risperidona:
English: Lipid Lowering Drugs Lovastatin, simvastatin, atorvastatin*
Croatian: Lovastatin, simvastatin, atorvastatin*
English: Treatment with ketoconazole in paediatric patients allowed normalisation of urinary free cortisol levels and clinical improvement, including recovering of growth rate and gonadal function, normalisation of blood pressure, Cushing's syndrome features and weight loss in most of the cases.
Croatian: Liječenje ketokonazolom u pedijatrijskih je bolesnika dovelo do normalizacije slobodnog kortizola u urinu i kliničkog poboljšanja uključujući oporavak brzine rasta i funkcije spolnih žlijezda, normalizaciju krvnog tlaka, poboljšanje karakteristika Cushingovog sindroma i gubitak težine u većini slučajeva.
English: Pharmacotherapeutic group: Antimycotics for systemic use, imidazole derivatives, ATC code: J02AB02
Croatian: Farmakoterapijska skupina: antimikotici za sistemsku primjenu, derivati imidazola, ATK oznaka: J02AB02
English: Due to the risk of serious hepatic toxicity, close follow-up of patients is required (see section 4.2).
Croatian: Zbog rizika od ozbiljne hepatičke toksičnosti potrebno je pomno pratiti stanje bolesnika (vidjeti dio 4.2).
English: It is used to treat endogenous Cushing's syndrome (when the body produces an excess of cortisol) in adults and adolescents above the age of 12 years.
Croatian: Koristi se za liječenje endogenog Cushingovog sindroma (kada tijelo proizvodi previše kortizola) u odraslih i adolescenata starijih od 12 godina.