FrancophonIA/ELRC3.0 huggingface dataset:
English: Multivariate analyses showed that baseline ALAT or ASAT above DAIDS Grade 1 and co-infection with hepatitis B or C were risk factors for these elevations.
Slovenian: Multivariantne analize so pokazale, da so izhodiščni ALAT ali ASAT nad 1. stopnjo DAIDS in sočasna okužba z virusom hepatitisa B ali C dejavniki tveganja za ta povečanja.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 25 October 2005
Slovenian: DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 25. oktober 2005 Datum zadnjega podaljšanja: 19. junij 2015
English: Dosage reduction and concentration monitoring of desipramine is recommended.
Slovenian: Priporočamo zmanjšanje odmerka in spremljanje koncentracije desipramina.
English: There may be other particles at the bottom of the bottle.
Slovenian: Na dnu so lahko tudi drugi delci.
English: Other medicines and Aptivus
Slovenian: Druga zdravila in zdravilo Aptivus
English: The following clinical data is derived from analyses of 48-week data from ongoing studies (RESIST-1 and RESIST-2) measuring effects on plasma HIV RNA levels and CD4 cell counts.
Slovenian: Navedeni klinični podatki izvirajo iz analiz 48-tedenskih podatkov potekajočih raziskav (RESIST-1 in RESIST-2), v katerih določajo učinke na ravni HIV RNA v plazmi in število celic CD4.
English: Moreover a study with TPV/r and another NNRTI (efavirenz) did not show any clinically relevant interaction (see above).
Slovenian: Še več, raziskava o TPV/r in drugih NNRTI (efavirenzemu) ni odkrila nikakršnih klinično pomembnih interakcij (glejte zgoraj).
English: Tabulated summary of adverse reactions associated with Aptivus based on clinical studies and postmarketing experience:
Slovenian: Preglednica s povzetkom neželenih učinkov, povezanih z zdravilom Aptivus, na podlagi podatkov iz kliničnih študij in izkušenj iz obdobja trženja zdravila:
English: The increase in carbamazepine total PK parameters is not expected to have clinical consequences.
Slovenian: Povečanje karbamazepinovih skupnih farmakokinetičnih parametrov predvidoma nima kliničnih učinkov.
English: There have been reports of increased bleeding, including spontaneous skin haematomas and haemarthrosis in patients with haemophilia type A and B treated with protease inhibitors.
Slovenian: Poročali so o povečanem krvavenju, tudi spontanih hematomih na koži in hemartrozi, ki so se pojavili pri bolnikih s hemofilijo tipa A in B, zdravljenih z zaviralci proteaze.
English: Propafenone Metoprolol (given in heart failure)
Slovenian: Metoprolol (pri srčnem popuščanju)
English: Increased ALAT/ASAT monitoring should be considered in these patients.
Slovenian: Pri teh bolnikih je treba pogosteje spremljati ALAT ali ASAT.
English: Serious side effects associated with Aptivus:
Slovenian: Resni, z zdravilom Aptivus povezani neželeni učinki:
English: To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease, or epilepsy.
Slovenian: Vsebnost alkohola je treba upoštevati pri nosečnicah in doječih ženskah, otrocih in zelo ogroženih skupinah, na primer bolnikih z boleznijo jeter ali epilepsijo.
English: Women using oestrogens may have an increased risk of non serious rash.
Slovenian: Pri ženskah, ki jemljejo estrogene, se lahko poveča tveganje manj resnega izpuščaja.
English: Tipranavir demonstrates antiviral activity in vitro against a broad panel of HIV-1 group M non-clade B isolates (A, C, D, F, G, H, CRF01 AE, CRF02 AG, CRF12 BF).
Slovenian: Za tipranavir je dokazan protivirusni učinek in vitro proti velikemu naboru izolatov virusov HIV-1 iz skupine M, ki niso iz genotipske skupine B (A, C, D, F, G, H, CRF01 AE, CRF02 AG, CRF12 BF).
English: Alpha 1-adrenoreceptor antagonists Alfuzosin
Slovenian: Antagonisti adrenergičnih receptorjev alfa-1 Alfuzosin
English: PHARMACEUTICAL FORM AND CONTENTS 95 ml oral solution (1 bottle) Oral syringe
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 95 ml peroralne raztopine (1 steklenica) Peroralna brizga
English: The combination should be used with caution and a lower dose of trazodone should be considered.
Slovenian: Zato je treba kombinacijo uporabljati previdno in obenem razmisliti o uporabi manjšega odmerka trazodona.
English: Recommendations for maximal doses of omeprazole or esomeprazole are found in the corresponding product information.
Slovenian: Priporočila o največjih odmerkih omeprazola ali esomeprazola so v ustrezni informaciji o zdravilu.
English: However, in some cases the role of Aptivus cannot be excluded.
Slovenian: V nekaterih primerih pa vloge zdravila Aptivus ne moremo izključiti.
English: See also Section 2, under “Oral contraceptives/hormone replacement therapy (HRT)”.
Slovenian: Glejte tudi poglavje 2: ''Peroralni kontraceptivi ali hormonsko nadomestno zdravljenje''.
English: Additional changes included bleeding in rats at high doses (rodents specific).
Slovenian: Druge spremembe so bile krvavitve pri podganah po dajanju velikih odmerkov (specifične za glodavce).
English: Paediatric population The oral solution has been shown to have greater bioavailability than the soft capsule formulation.
Slovenian: Pediatrična populacija Pokazalo se je, da ima peroralna raztopina večjo biološko uporabnost kot mehke kapsule.
English: All patients initially received Aptivus oral solution.
Slovenian: Vsi bolniki so na začetku prejemali peroralno raztopinoAptivus.
English: In the paediatric clinical trial, the frequency of rash (all grades, all causality) through 48 weeks of treatment was higher than in adult patients.
Slovenian: V klinični raziskavi pri otrocih je bila pogostnost izpuščaja (vseh stopenj in iz vseh vzrokov) v 48-tedenskem obdobju zdravljenja večja kot pri odraslih bolnikih.
English: There was no pattern for the bleeding events and no difference between treatment groups in coagulation parameters.
Slovenian: Za epizode krvavitev ni bilo vzorca in med skupinami ni bilo razlik glede na koagulacijske parametre.
English: Check that the oral solution is clear (see below).
Slovenian: Preverite, ali je peroralna raztopina prozorna (glejte spodaj).
English: A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE Name and address of the manufacturer responsible for batch release Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Strasse 173, D-55216 Ingelheim am Rhein, Germany.
Slovenian: A. IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ Ime in naslov izdelovalca, odgovornega za sproščanje serij Boehringer Ingelheim Pharma GmbH & Co.KG, Binger Strasse 173, D-55216 Ingelheim am Rhein, Nemčija
English: According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended
Slovenian: Sedanje smernice dvotirnega zdravljenja z zaviralci proteaze na splošno ne priporočajo.
English: Patients should be instructed to observe closely for crystals.
Slovenian: Bolnike je treba poučiti, naj bodo pozorni na prisotnost kristalov.
English: If your HIV is resistant to some HIV medicines, this means that the medicine will not work so well, or will not work at all.
Slovenian: Če je odporen proti nekaterim zdravilom, ta zdravila ne bodo tako dobro učinkovala ali sploh ne bodo delovala.
English: Mutations at position 82 occur via two pathways: one from preexisting mutation 82A selecting to 82T, the other from wild type 82V selecting to 82L.
Slovenian: Do mutacij na mestu 82 pride po dveh poteh: s prejšnje mutacije 82A, ki se selekcionira v 82T, in z 82V divjega tipa, ki se selekcionira v 82L.
English: Aptivus may lead to a loss of effectiveness of some medicines including: - methadone, meperidine (pethidine), used as morphine substitutes
Slovenian: Zdravilo Aptivus lahko povzroči neučinkovitost nekaterih zdravil, kot sta: metadon, meperidin (petidin), ki ju uporabljajo za nadomeščanje morfina.
English: If affected, you should not drive or operate machinery.
Slovenian: Če se pojavita, ne smete voziti ali upravljati strojev.
English: Due to Aptivus containing small amounts of sorbitol, patients with rare hereditary problems of fructose intolerance should not take this medicine.
Slovenian: Glede na to, da zdravilo Aptivus vsebuje majhno količino sorbitola, ga bolniki, ki imajo redke prirojene težave z netoleranco za fruktozo, ne smejo jemati.
English: There have been reports of muscle pain, tenderness or weakness.
Slovenian: V poročilih navajajo mišično bolečino, občutljivost za dotik ali šibkost.
English: With respect to mutations on codons 33, 82, 84 and 90 approximately 4% had no mutations, 24% had mutations at codons 82 (less than 1% of patients had the mutation V82L) and 90, 18% had mutations at codons 84 and 90 and 53% had at least one key mutation at codon 90.
Slovenian: Glede na mutacije na kodonih 33, 82, 84 in 90, jih približno 4% ni imelo mutacij, 24% jih je imelo mutacije na kodonih 82 (manj kot 1% bolnikov je imelo mutacijo V82L) in 90, 18% jih je imelo mutacije na kodonih 84 in 90 ter53% jih je imelo najmanj eno ključno mutacijo na kodonu 90.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Slovenian: Če vam je vaš zdravnik povedal, da ne prenašate nekaterih sladkorjev, se posvetujte s svojim zdravnikom preden vzamete to zdravilo.
English: You should return the bottle to your child's pharmacist or doctor for a replacement as soon as possible if: - there is more than a thin layer of crystals at the bottom of the bottle, or - you are uncertain about the amount of crystals you see or - any other particles are visible.
Slovenian: Steklenico morate čim prej vrniti otrokovemu farmacevtu ali zdravniku in jo zamenjati za novo, če: je na njenem dnu več kot le tanka plast kristalov ali ste negotovi o vidni količini kristalov ali so vidni kakršnikoli drugi delci.
English: Additional side effects in children and adolescents The most common side effects were generally similar to those described in adults.
Slovenian: Dodatni neželeni učinki pri otrocih in mladostnikih Najpogostejši neželeni učinki so bili večinoma podobni kot pri odraslih.
English: Aptivus should be used in this patient population only if the potential benefit outweighs the potential risk, and with increased clinical and laboratory monitoring.
Slovenian: Pri tej populaciji bolnikov smemo zdravilo Aptivus uporabiti le, če je možna korist zdravljenja večja od možnega tveganja ter ob pogostnejšem kliničnem in laboratorijskem spremljanju.
English: However, if atorvastatin is specifically required for patient management, it should be started with the lowest dose and careful monitoring is necessary.
Slovenian: Če je za zdravljenje treba uporabiti atorvastatin, je treba začeti z najmanjšim odmerkom in je potrebno skrbno spremljanje.
English: Based on data from the cocktail study where caffeine (CYP1A2 substrate) AUC was reduced by 43%, tipranavir with ritonavir is expected to decrease theophylline concentrations.
Slovenian: Na podlagi podatkov iz koktajl raziskave, v kateri se je AUC kofeina (substrat za CYP 1A2) zmanjšala za 43%, sočasna uporaba tipranavirja ob ritonavirju predvidoma zmanjša koncentracijo teofilina.
English: ENF Enfuvirtide; FAS Full Analysis Set; PP Per Protocol; APV/rtv Amprenavir/ritonavir; IDV/rtv Indinavir/ritonavir; LPV/rtv Lopinavir/ritonavir; SQV/rtv Saquinavir/ritonavir
Slovenian: ENF enfuvirtid; FAS popolna analiza (Full Analysis Set); PP po protokolu; APV/rtv amprenavir/ritonavir; IDV/rtv indinavir/ritonavir; LPV/rtv lopinavir/ritonavir; SKV/rtv sakinavir/ritonavir
English: The development of resistance to tipranavir in vitro is slow and complex.
Slovenian: Odpornost proti tipranavirju se in vitro razvija počasi in kompleksno.
English: Baseline CD4+ (cells/mm
Slovenian: Izhodiščno število CD4+ (celic/mm
English: In general, adverse reactions were similar to those seen in adults, with the exception of vomiting, rash and pyrexia which were reported more frequently in children than in adults.
Slovenian: Na splošno so bile neželene reakcije podobne kot pri odraslih, z izjemo bruhanja, izpuščaja in pireksije, o katerih so poročali bolj pogosto pri otrocih kot pri odraslih.
English: 3, respectively, (ranges 1-1893 and 1
Slovenian: (1 do 1893 in 1 do
English: If patients experience fatigue, dizziness, or somnolence they should avoid potentially hazardous tasks such as driving or operating machinery.
Slovenian: Bolniki, pri katerih se pojavijo utrujenost, omotica ali zaspanost, se morajo izogibati dejavnostim, ki so lahko nevarne, na primer vožnji ali upravljanju strojev.
English: Consistent with the recommendation that HIV-infected mothers should not breast-feed their infants under any circumstances to avoid risking postnatal transmission of HIV, mothers should discontinue breast-feeding if they are receiving Aptivus.
Slovenian: Glede na priporočilo, naj s HIV okužene matere v nobenem primeru ne smejo dojiti, da bi se izognile tveganju poporodnega prenosa HIV, morajo prenehati dojiti tudi med zdravljenjem z zdravilomAptivus.
English: You should follow the instructions for these medicines within the supplied Package Leaflets.
Slovenian: Upoštevati morate navodila, priložena tem zdravilom.
English: More frequent concentration monitoring of these medicinal products is recommended until blood levels have been stabilised.
Slovenian: Dokler se krvne ravni ne stabilizirajo, je priporočljivo pogostnejše spremljanje koncentracij teh zdravil.
English: In a pharmacokinetic study of healthy volunteers, boceprevir decreased the exposure of ritonavir, and some ritonavir-boosted protease inhibitors.
Slovenian: V farmakokinetični študiji pri zdravih prostovoljcih je boceprevir zmanjšal izpostavljenost ritonavirju in nekaterim z njim okrepljenih zaviralcev proteaze.
English: Always take this medicine in combination with other antiretroviral medicines.
Slovenian: To zdravilo vedno jemljite v kombinaciji z drugimi protiretrovirusnimi zdravili.
English: It is believed that these symptoms are due to an improvement in the body's immune response, enabling the body to fight infections that may have been present with no obvious symptoms.
Slovenian: Menijo, da so ti simptomi posledica izboljšanja telesnega imunskega odziva, zaradi katerega se organizem brani pred okužbami, katere do tedaj niso povzročale očitnih simptomov.
English: Make sure the oral syringe is tightly inserted.
Slovenian: Preverite, ali je peroralna brizga trdno vstavljena.
English: You should know that you may continue to develop infections and other illnesses associated with HIV disease.
Slovenian: Zavedati se morate, da se pri vas še nadalje lahko razvijajo okužbe in druge bolezni, povezane z boleznijo, ki jo povzroča okužba s HIV.
English: Interactions with other HIV medicines: - etravirine belongs to a class of HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Slovenian: Interakcije z drugimi zdravili proti HIV: - Etravirin spada v skupino zdravil za zdravljenje okužbe s HIV, ki se imenujejo nenukleozidni zaviralci reverzne transkriptaze (NNRTI).
English: There is increased potential for PDE5 inhibitorassociated adverse events (which include visual disturbances, hypotension, prolonged erection, and syncope).
Slovenian: Povečana je možnost neželenih učinkov zaviralca PDE5 (pojav motenj vida, hipotenzije, podaljšane erekcije in sinkope).
English: The most frequently reported moderate or severe adverse reactions in the 48 week analyses are noted below.
Slovenian: Najpogostnejši zmerni ali hudi neželeni učinki v 48-tedenski analizi so navedene spodaj.
English: If your child stops taking Aptivus It has been shown that taking all doses at the appropriate times: - greatly increases the effectiveness of your child's combination antiretroviral medicines - reduces the chances of your child's HIV becoming resistant to his/her antiretroviral medicines.
Slovenian: Če je vaš otrok prenehal jemati zdravilo Aptivus Pokazalo se je, da se ob jemanju vseh odmerkov ob ustreznem času: močno poveča učinkovitost kombinacije protiretrovirusnih zdravil, ki jih jemlje vaš otrok; zmanjša možnost, da bi HIV postal odporen proti otrokovim protiretrovirusnim zdravilom.
English: Dizziness, somnolence, and fatigue have been reported in some patients; therefore, caution should be recommended when driving a car or operating machinery.
Slovenian: Pri nekaterih bolnikih so poročali o omotici, zaspanosti in utrujenosti, zato je treba bolnikom svetovati, naj bodo pri vožnji avtomobila ali upravljanju strojev previdni.
English: rilpivirine: If your child is taking rilpivirine, your child's doctor will monitor your child closely.
Slovenian: Rilpivirin: Če vaš otrok jemlje rilpivirin, bo zdravnik zdravljenje vašega otroka natančno spremljal.
English: At 48-weeks the relative risk decreased to 1.27 (95% CI=0.76, 2.12).
Slovenian: Po 48 tednih se je relativno tveganje zmanjšalo na 1,27 (95-odstotni interval zaupanja = 0,76; 2,12).
English: For patients with renal impairment dose reduction of clarithromycin should be considered (see clarithromycin and ritonavir product information).
Slovenian: Pri bolnikih z ledvično okvaro je treba presoditi o zmanjšanju odmerka klaritromicina (glejte informacijo o zdravilih klaritromicin in ritonavir).
English: Aptivus contains very small amounts of alcohol (see Aptivus capsules contain ethanol).
Slovenian: ZdraviloAptivus vsebuje zelo majhne količine alkohola (glejte ZdraviloAptivuskapsule vsebuje etanol).
English: Discuss with your child's doctor the precautions needed to avoid infecting other people.
Slovenian: Posvetujte se z otrokovim zdravnikom o previdnostnih ukrepih, potrebnih za preprečitev okužbe drugih ljudi.
English: You should know that your child may continue to develop infections and other illnesses associated with HIV disease.
Slovenian: Zavedeti se morate, da se pri vašem otroku še nadalje lahko razvijajo okužbe in druge bolezni, povezane z boleznijo, ki jo povzroča okužba s HIV.
English: If your child forgets to take Aptivus
Slovenian: Če je vaš otrok pozabil vzeti zdravilo Aptivus
English: Bone problems: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Težave s kostmi: Pri nekaterih bolnikih, ki jemljejo kombinirano protiretrovirusno zdravljenje, se lahko pojavi bolezen kosti, imenovana osteonekroza (odmiranje kostnega tkiva zaradi nezadostne prekrvavitve kosti).
English: Tipranavir is a non-peptidic inhibitor of the HIV-1 protease that inhibits viral replication by preventing the maturation of viral particles.
Slovenian: Tipranavir je nepeptidni zaviralec proteaze HIV-1, ki zavira virusno replikacijo, tako da prepreči dozorevanje virusnih delcev.
English: These effects are called interactions, and can lead to serious side effects, or prevent proper control of other conditions you may have.
Slovenian: Te učinke imenujemo interakcije in lahko povzročijo resne neželene učinke ali preprečijo ustrezen nadzor vaših drugih bolezni.
English: Due to this and to the high vitamin E content of the oral solution, the risk of adverse reactions (type, frequency and/or severity) may be higher than with the capsule formulation.
Slovenian: Iz tega razloga in zaradi velike vsebnosti vitamina E v peroralni raztopini je lahko tveganje neželenih reakcij (vrsta, pogostnost ali resnost) večje kot pri zdravilu v obliki kapsul.
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination therapy and should be monitored according to standard practice.
Slovenian: Pri bolnikih z obstoječo jetrno disfunkcijo, tudi kroničnim aktivnim hepatitisom, se med kombiniranim zdravljenjem poveča pogostnost motenj jetrnega delovanja, zato jih moramo spremljati v skladu s standardno prakso.
English: Very common (≥ 1/10), common (≥ 1/100 to 1/10), uncommon (≥1/1,000 to 1/100), rare (≥1/10,000 to 1/1,000)
Slovenian: Razvrščeni so po organskih sistemin in pogostnosti v naslednje skupine: zelo pogosti (≥ 1/10); pogosti (≥ 1/100 do < 1/10); občasni (≥ 1/1.000 do < 1/100); redki (≥ 1/10.000 do < 1/1.000).
English: Administer Aptivus oral solution immediately.
Slovenian: Peroralno raztopino Aptivus takoj uporabite.
English: Total plasma tipranavir concentrations for these samples ranged from 9 to 82 M.
Slovenian: Razpon skupnih koncentracij je bil pri teh vzorcih 9 do 82 μM.
English: The reduction of bupropion plasma levels is likely due to induction of CYP2B6 and UGT activity by RTV
Slovenian: Zmanjšanje ravni bupropiona v plazmi je lahko posledica indukcije CYP 2B6 in aktivnosti UGT z RTV.
English: Ritonavir is a potent inhibitor of CYP3A4 and therefore affect drugs metabolised by this enzyme.
Slovenian: Ritonavir je močan zaviralec CYP 3A4, zato vpliva na zdravila, ki jih ta encim presnavlja.
English: The clinical implications of these findings are not known.
Slovenian: Klinični pomen teh izsledkov ni znan.
English: Combination of all three of these is usually required for reduced susceptibility.
Slovenian: Za pojav zmanjšane občutljivosti je običajno potrebna kombinacija treh od teh mutacij.
English: A small amount of crystals does not affect the strength or safety of your child's medicine.
Slovenian: Če je kristalov malo, ne vplivajo na jakost ali varnost otrokovega zdravila.
English: Your child's doctor, together with you, will decide which other medicines your child should take.
Slovenian: Otrokov zdravnik bo skupaj z vami določil, katera druga zdravila mora vaš otrok jemati.
English: It is recommended to prescribe tadalafil after at least 7 days of Aptivus with ritonavir dosing.
Slovenian: Tadalafil je priporočeno predpisati vsaj 7 dni po odmerku zdravila Aptivus ob ritonavirju.
English: As demonstrated in a doseranging evaluation in 113 HIV-negative healthy male and female volunteers, ritonavir increases AUC012h, Cmax and Cmin and decreases the clearance of tipranavir.
Slovenian: Med določanjem razpona odmerka pri 113 HIV-negativnih zdravih prostovoljcih moškega in ženskega spola se je pokazalo, da ritonavir poveča AUC0-12h, Cmax in Cmin tipranavirja in zmanjša njegov očistek.
English: A pharmacodynamic interaction study in healthy volunteers demonstrated that administration of loperamide and Aptivus, coadministered with low dose ritonavir, does not cause any clinically relevant change in the respiratory response to carbon dioxide.
Slovenian: Raziskava o farmakodinamičnih interakcijah pri zdravih prostovoljcih je pokazala, da dajanje loperamida in zdravila Aptivus ob hkratnih majhnih odmerkih ritonavirja ne povzroči nikakršnih klinično pomembnih sprememb respiratornega odziva na ogljikov dioksid.
English: This will depend on, for example: which other medicines you have already taken for HIV which medicines your HIV is resistant to.
Slovenian: To bo na primer odvisno od tega: - katera druga zdravila proti virusu HIV ste že jemali, - proti katerim zdravilom je HIV pri vas odporen.
English: The decrease in tipranavir concentrations may result in decreased effectiveness.
Slovenian: Zaradi zmanjšanja tipranavirjeve koncentracije se lahko zmanjša učinkovitost.
English: Aptivus should neither be used by children under 2 years of age nor by adolescents 12 years of age or older.
Slovenian: Otrociin mladostniki Zdravila Aptivus nikoli ne smejo uporabljatiotroci mlajši od 2 let niti mladostniki stari 12 let ali več.
English: When coadministered with ritonavir at the recommended dosage (see section 4.2) there is a net inhibition of P450 CYP3A.
Slovenian: Ob hkratnem dajanju z ritonavirjem v priporočenih odmerkih (glejte poglavje 4.2) je neto učinek zaviranje P450 CYP3A.
English: Recombinant viruses showing ≥ 3fold resistance to tipranavir grow at less than 1% of the rate detected for wild type HIV-1 in the same conditions.
Slovenian: Število rekombinantnih virusov, ki so ≥ 3-kratno odporni proti tipranavirju, naraščajo s stopnjo, ki znaša v enakih razmerah manj kot 1% stopnje pri virusu divjega tipa.
English: Tipranavir is a P-gp substrate, a weak P-gp inhibitor and appears to be a potent P-gp inducer as well.
Slovenian: Tipranavir je substrat P-gp, šibak zaviralec P-gp in kaže, da tudi močan induktor P-gp.