FrancophonIA/ELRC3.0 huggingface dataset:
English: Post-hoc analyses in a subgroup of patients with high cardiovascular risk at baseline (as defined by transient ischemic attack, angina pectoris, heart failure, myocardial infarction, peripheral vascular disease and/or stroke), showed that the incidence of Major Adverse Cardiovascular Events was 1/52 for placebo and 4/53 for Zurampic 200 mg, when used in combination with a xanthine oxidase inhibitor.
Danish: Post-hoc-analyser i en subgruppe af patienter med en høj kardiovaskulær risiko ved baseline (defineret som transitorisk cerebral iskæmi, angina pectoris, hjertesvigt, myokardieinfarkt, perifer vaskulær sygdom og/eller apopleksi) viste, at forekomsten af alvorlige kardiovaskulære bivirkninger (Major Adverse Cardiovascular Events) var 1/52 for placebo og 4/53 for Zurampic 200 mg ved kombination med en xanthinoxidasehæmmer.
English: A higher incidence of serum creatinine elevations and renal-related adverse reactions including serious adverse reactions was observed with Zurampic 400 mg when given alone or in combination with a xanthine oxidase inhibitor, with the highest incidence when Zurampic was given as monotherapy.
Danish: Der er observeret en højere forekomst af stigning i serumkreatitin og renale bivirkninger, herunder alvorlige bivirkninger, med Zurampic 400 mg, når dette blev givet alene eller i kombination med en xanthinoxidasehæmmer, med den højeste forekomst ved Zurampic som monoterapi.
English: Lesinurad should only be used in combination with a xanthine oxidase inhibitor because combination use reduces the amount of uric acid available for excretion and decreases the risk of renal-related events.
Danish: Lesinurad bør kun anvendes i kombination med en xanthinoxidasehæmmer, fordi kombinationen reducerer mængden af urinsyre, der er tilgængelig for udskillelse, og reducerer risikoen for nyrerelaterede bivirkninger.
English: - acetylsalicylic acid - to relieve fever and pain - at doses above 325 mg per day - medicines to treat high blood pressure, e.g. amlodipine - medicines to treat high cholesterol levels, e.g. simvastatin - fluconazole - to treat fungal infections - amiodarone -to treat heart rhythm problems - valproic acid,valpromideor carbamazepine -to treatfits (seizures), mood disorders and prevent migraines - sildenafil - to treat erectile dysfunction - contraceptives-used to preventpregnancy,including oralcontraception (such as ‘the pill'),
Danish: - acetylsalicylsyre - mod feber og smerter - i doser over 325 mg pr. dag - medicin til behandling af forhøjet blodtryk, fx amlodipin - medicin til behandling af forhøjet kolesterol, fx simvastatin - fluconazol - til behandling af svampeinfektioner - amiodaron - til behandling af problemer med hjerterytmen - valproinsyre, valpromid eller carbamazepin - til behandling af kramper, humørforstyrrelser og til at forebygge migræne - sildenafil - til behandling af impotens (erektil dysfunktion) - præventionsmidler - bruges til at forhindre graviditet, herunder orale præventionsmidler (såsom p-piller), injektionsvæsker, plastre og implantater - rifampin - til behandling af tuberkulose - warfarin - til forebyggelse og behandling af blodpropper i ben, lunger, hjerne og hjerte.
English: Although other doses have been studied, the recommended dose of Zurampic is 200 mg once daily in combination with a xanthine oxidase inhibitor.
Danish: Selvom andre doser er undersøgt, er den anbefalede Zurampic-dosis 200 mg én gang dagligt i kombination med en xanthinoxidasehæmmer.
English: Patients continued their allopurinol dose and were randomised 1:1:1 to receive Zurampic 200 mg, Zurampic 400 mg, or placebo once daily.
Danish: Patienterne fortsatte med deres allopurinoldosis og blev randomiseret 1:1:1 til at få Zurampic 200 mg, Zurampic 400 mg eller placebo én gang dagligt.
English: Zurampic tablets must be co-administered at the same time as the morning dose of a xanthine oxidase inhibitor, i.e. allopurinol or febuxostat.
Danish: Zurampic-tabletter skal indtages samtidig med morgendosis af en xanthinoxidasehæmmer, dvs. allopurinol eller febuxostat.
English: Following administration of a single dose of lesinurad at 400 mg in patients with mild (Child-Pugh class A) or moderate (Child-Pugh class B) hepatic impairment, lesinurad Cmax was comparable and lesinurad AUC was 7% and 33% higher, respectively, compared to individuals with normal hepatic function.
Danish: Efter administration af en enkelt dosis lesinurad 400 mg til patienter med let nedsat leverfunktion (Child-Pugh klasse A) eller moderat nedsat leverfunktion (Child-Pugh klasse B) var lesinurad-Cmax sammenlignelig med Cmax, hos personer med normal leverfunktion, og lesinurad-AUC var henholdsvis 7 % og 33 % højere end AUC hos personer med normal leverfunktion.
English: Zurampic as add-on to allopurinol in inadequate responders CLEAR1 and CLEAR2 enrolled patients with gout who were on a stable dose of allopurinol of at least 300 mg (or 200 mg for moderate renal impairment), had serum uric acid levels greater than 6.5 mg/dL and reported at least 2 gout flares in the previous 12 months.
Danish: Zurampic som tillægsbehandling til allopurinol hos patienter med utilstrækkeligt respons CLEAR1 og CLEAR2 inkluderede patienter med urinsyregigt, som fik en stabil dosis allopurinol på mindst 300 mg (eller 200 mg ved moderat nedsat nyrefunktion), havde serumurinsyre over 6,5 mg/dl og rapporterede mindst 2 udbrud af urinsyregigt i de foregående 12 måneder.
English: In patients with moderate renal impairment, the incidence of renalrelated adverse reactions was similar across all treatment groups: Zurampic 200 mg (12.7%), Zurampic 400 mg (16.3%) and placebo (13.3%).
Danish: Hos patienter med moderat nedsat nyrefunktion var forekomsten af nyrerelaterede bivirkninger den samme i alle behandlingsgrupperne: Zurampic 200 mg (12,7 %), Zurampic 400 mg (16,3 %) og placebo (13,3 %).
English: What Zurampic looks like and contents of the pack Zurampic 200 mg: a blue, oval, dimensions 5.7 x 12.9 mm, film-coated tablet, engraved with “LES200” on one side.
Danish: Zurampic 200 mg: en blå, oval filmovertrukket tablet, der måler 5,7 x 12,9 mm, præget med “LES200” på den ene side.
English: Zurampic causes an increase in renal uric acid excretion, which may lead to transient increases in serum creatinine, renal-related adverse reactions and kidney stones.
Danish: Zurampic medfører en øget renal udskillelse af urinsyre, hvilket kan føre til forbigående stigninger i serumkreatinin, nyrerelaterede bivirkninger og nyresten.
English: Zurampic must be taken together with allopurinol or febuxostat, which are medicines called ‘xanthine oxidase inhibitors' and are also used to treat gout by lowering the amount of uric acid in your blood.
Danish: Zurampic skal tages sammen med allopurinol eller febuxostat, som er lægemidler, der kaldes xanthinoxidasehæmmere, og som også nedsætter mængden af urinsyre i blodet.
English: In the subgroup of patients with a baseline sUA ≥5.0 mg/dL, after 3 weeks of febuxostat therapy, a significant difference was achieved at all study visits for Zurampic 200 mg in combination with febuxostat compared with placebo in combination with febuxostat (see Table 3).
Danish: I undergruppen af patienter med baseline-sUA ≥5,0 mg/dl efter 3 ugers behandling med febuxostat var der ved alle studiebesøg opnået en signifikant forskel for Zurampic 200 mg i kombination med febuxostat sammenlignet med placebo i kombination med febuxostat (se Tabel 3).
English: Lesinurad exposure is expected to decrease when it is co-administered with inducers of CYP2C9 (e.g. carbamazepine, a moderate CYP2C9 inducer).
Danish: Lesinurads eksponering forventes at falde, når det administreres samtidig med CYP2C9-induktorer (fx carbamazepin, der er en moderat CYP2C9-induktor).
English: In the pivotal clinical trials, a greater proportion of patients using lipid lowering or antihypertensive medicines that were CYP3A substrates required concomitant medicinal product change when treated with Zurampic 200 mg in combination with a xanthine oxidase inhibitor, compared with patients treated with placebo in combination with a xanthine oxidase inhibitor (35% versus 28%, respectively).
Danish: I de pivotale kliniske studier havde en større andel af patienter, der anvendte lipidsænkende eller antihypertensive lægemidler, der var CYP3A-substrater, brug for ændring af det samtidige lægemiddel, når de blev behandlet med Zurampic 200 mg i kombination med en xanthinoxidasehæmmer, sammenlignet med patienter, der fik placebo i kombination med en xanthinoxidasehæmmer (henholdsvis 35 % versus 28 %).
English: Patients received febuxostat 80 mg once daily for 3 weeks and then were randomised 1:1:1 to once daily doses of Zurampic 200 mg, Zurampic 400 mg, or placebo in combination with febuxostat.
Danish: Patienterne fik febuxostat 80 mg én gang dagligt i 3 uger og blev derefter randomiseret 1:1:1 til Zurampic 200 mg, Zurampic 400 mg eller placebo én gang dagligt i kombination med febuxostat.
English: In vitro, lesinurad is an inhibitor of CYP2C8, but not of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and mEH.
Danish: In vitro hæmmer lesinurad CYP2C8, men ikke CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 og mEH.
English: Zurampic should not be administered with inhibitors of mEH.
Danish: Zurampic bør ikke administreres sammen med mEH-hæmmere.
English: Taking this medicine - take in the morning with food and water - takeZurampic at the same time as yourmorning dose of‘xanthine oxidase inhibitor' medicine allopurinol or febuxostat.
Danish: Sådan tager du denne medicin - tag den om morgenen med mad og vand - tag Zurampic samtidig med din morgendosis af xanthinoxidasehæmmer - allopurinol eller febuxostat.
English: The effect of CYP2C9 genotype on the pharmacokinetics of lesinurad was studied in 8 healthy subjects and 59 patients with gout following daily dosing of lesinurad ranging from 200 mg to 600 mg in the absence or presence of a xanthine oxidase inhibitor.
Danish: Effekten af CYP2C9-genotyper på lesinurads farmakokinetik blev undersøgt hos 8 raske forsøgspersoner og hos 59 patienter med urinsyregigt efter daglig dosering af lesinurad, der varierede fra 200 mg til 600 mg, uden eller med samtidig administration af en xanthinoxidasehæmmer.
English: Effects on serum uric acid and urinary excretion of uric acid In healthy subjects, lesinurad 200 mg lowered sUA levels and increased renal clearance and fractional excretion of uric acid.
Danish: Virkning på serumurinsyre og udskillelse af urinsyre i urinen Hos raske forsøgspersoner reducerede lesinurad 200 mg sUA og øgede renal clearance og fraktionel udskillelse af urinsyre.
English: Patients with a history of kidney stones were permitted entry into the 12-month studies of Zurampic in combination with a xanthine oxidase inhibitor.
Danish: Patienter med nyresten i anamnesen blev også inkluderet i studierne af 12 måneders varighed med Zurampic i kombination med en xanthinoxidasehæmmer.
English: Table 3 Proportion of patients with baseline sUA ≥5.0 mg/dLwho achieve target serum uric acid levels (<5 mg/dL) with Zurampic in combination with febuxostat
Danish: Tabel 3 Andel af patienter med baseline sUA ≥5,0 mg/dl, som når det ønskede målniveau for serumurinsyre (<5 mg/dl) med Zurampic i kombination med febuxostat
English: Lesinurad is not an in vitro inhibitor of P-glycoprotein, BCRP, OATP1B3, MRP2, MRP4, OCT2, MATE1 and MATE2-K.
Danish: Lesinurad hæmmer ikke P-glykoprotein, BCRP, OATP1B3, MRP2, MRP4, OCT2, MATE1 eller MATE2-K in vitro.
English: Mild to moderate induction of CYP3A by lesinurad may reduce plasma exposures of co-administered medicines that are sensitive substrates of CYP3A.
Danish: Lesinurad kan inducere CYP3A i let til moderat grad og reducere plasmaeksponeringen af samtidigt administrerede lægemidler, der er sensitive CYP3A-substrater.
English: In rats, there was no effect on mating or fertility with lesinurad (see section 5.3).
Danish: Hos rotter påvirkede lesinurad ikke parring eller fertilitet (se pkt.
English: Lesinurad is a substrate of OATP1B1, OAT1, OAT3 and OCT1.
Danish: Lesinurad er substrat for OATP1B1, OAT1, OAT3 og OCT1.
English: Zurampic should be used with caution in patients with a CrCL of 30 to less than 45 mL/min (see section 4.4).
Danish: Zurampic bør anvendes med forsigtighed til patienter med CrCL på 30 til < 45 ml/min (se pkt.
English: In clinical trials, Zurampic was administered with food, because the serum uric acid lowering was improved under fed conditions.
Danish: I kliniske studier blev Zurampic administreret ved samtidig fødeindtagelse, fordi nedsættelsen af serumurinsyre blev forbedret efter fødeindtagelse.
English: Summary of the safety profile
Danish: Resumé af bivirkningsprofilen:
English: Severe renal impairment (CrCL less than 30 mL/min), end-stage renal disease, kidney transplant recipients or patients on dialysis (see section 4.2).
Danish: Svært nedsat nyrefunktion (CrCL < 30 ml/min), nyresygdom i slutstadie, nyretransplanterede patienter og patienter i dialyse (se pkt.
English: How to take Zurampic
Danish: Sådan skal du tage Zurampic
English: Gout flare prophylaxis with colchicine or an NSAID is recommended for at least 5 months when starting Zurampic therapy (see section 4.2).
Danish: Forebyggelse af udbrud af urinsyregigt med colchicin eller et NSAID anbefales i mindst 5 måneder, når behandling med Zurampic indledes (se pkt.
English: Female patients of childbearing age should practice additional methods of contraception and not rely on hormonal contraception alone when taking Zurampic (see sections 4.5 and 4.6).
Danish: Kvindelige patienter i den fertile alder bør anvendes ekstra præventionsmetoder og ikke stole på de hormonelle præventionsmidler alene ved samtidig anvendelse af Zurampic (se pkt.
English: Gout flare prophylaxis with colchicine or a nonsteroidal anti-inflammatory drug (NSAID) is recommended for at least 5 months when starting therapy (see section 4.4).
Danish: Profylakse mod udbrud af urinsyregigt med colchicin eller et nonsteroidt antiinflammatorisk lægemiddel (NSAID) anbefales i mindst 5 måneder, efter behandlingen er indledt (se pkt.
English: Zurampic in combination with febuxostat in tophaceous gout CRYSTAL enrolled gout patients with measurable tophi.
Danish: Zurampic i kombination med febuxostat ved toføs urinsyregigt CRYSTAL inkluderede urinsyregigtpatienter med målbare tofi.
English: Since the incidence of severe renal-related adverse events was increased with the monotherapy as compared to the combination therapy with a xanthine oxidase inhibitor, Zurampic should not be used as monotherapy (see sections 4.2 and 5.1).
Danish: Da forekomsten af alvorlige nyrerelaterede bivirkninger var højere med monoterapi i forhold til kombinationsbehandling med en xanthinoxidasehæmmer bør Zurampic ikke anvendes som monoterapi (se pkt.
English: Lesinurad is mainly metabolised by CYP2C9 and mEH, and to a lesser extent by CYP1A1, CYP2C19 and CYP3A.
Danish: Lesinurad metaboliseres primært af CYP2C9 og mEH, og i mindre grad af CYP1A1, CYP2C19 og CYP3A.
English: By lowering the amount of uric acid in the blood, Zurampic stops this accumulation and may prevent further joint damage.
Danish: Zurampic stopper denne ophobning ved at sænke mængden af urinsyre i blodet og kan muligvis forebygge yderligere ledskader.
English: No overall differences in safety of Zurampic were observed in patients with mild or moderate renal impairment (eCrCL of30-89 mL/min) compared to patients with normal renal function (see sections 4.2 and 5.2).
Danish: Der blev ikke set nogen samlet forskel i sikkerheden ved Zurampic hos patienter med let og moderat nedsat nyrefunktion (eCrCL 30-89 ml/min) i sammenligning med patienter med normal nyrefunktion (se pkt.
English: In each of the studies, a greater proportion of patients treated with Zurampic 200 mg in combination with allopurinol compared with placebo in combination with allopurinol achieved a serum uric acid less than 5 mg/dL by Month 6 (CLEAR1: 29% versus 10%; CLEAR2: 35% versus 5%).
Danish: I begge studier opnåede en større andel af patienter, som blev behandlet med Zurampic 200 mg i kombination med allopurinol, serumurinsyre under 5 mg/dl ved Måned 6 sammenlignet med placebo i kombination med allopurinol (CLEAR1: 29 % versus 10 %; CLEAR2: 35 % versus 5 %).
English: The stability of the sustained response was demonstrated with a greater proportion of patients treated with Zurampic 200 mg in combination with allopurinol achieving the target serum uric acid level at each visit for 3 consecutive months (Months 4, 5 and 6) compared to patients treated with placebo in combination with allopurinol (see Table 2).
Danish: Stabiliteten af det vedligeholdte respons blev demonstreret ved, at en større andel af patienter, som fik Zurampic 200 mg i kombination med allopurinol, opnåede målniveauet for serumurinsyre ved hvert besøg 3 måneder i træk (Måned 4, 5 og 6) sammenlignet med patienter, der fik placebo i kombination med allopurinol (se Tabel 2).
English: Effect of CYP2C9 genotype
Danish: CYP2C9-genotype
English: Zurampic should not be used during breast-feeding.
Danish: Zurampic bør ikke anvendes under amning.
English: Gastro-oesophageal reflux disease
Danish: Gastroøsofageal reflukssygdom
English: Zurampic does not need to be discontinued because of a gout flare.
Danish: Det er ikke nødvendigt at seponere Zurampic på grund af et udbrud af urinsyregigt.
English: Among serious renal-related adverse reactions: renal failure, renal failure acute and renal impairment were reported in 1.9%, 1.9% and 0.9% respectively, of patients receiving lesinurad 400 mg monotherapy and in no patients receiving placebo.
Danish: Af alvorlige nyrerelaterede bivirkninger blev der rapporteret nyresvigt, akut nyresvigt og nedsat nyrefunktion hos hhv. 1,9 %, 1,9 % og 0,9 % af de patienter, der fik lesinurad 400 mg monoterapi, og ikke hos nogen af de patienter, der fik placebo.
English: Lesinurad is a mild to moderate inducer of CYP3A (see section 4.5).
Danish: Lesinurad er en svag til moderat CYP3A-induktor (se pkt.
English: Proportion of patients who met serum uric acid target (<6.0 mg/dL) N (%)
Danish: Andel af patienter, som opfyldte målet for serumurinsyre (<6,0 mg/dl) N (%)
English: In vitro, lesinurad is an inhibitor of OATP1B1, OAT1, OAT3, OAT4 and OCT1 at clinically relevant plasma concentrations.
Danish: In vitro hæmmer lesinurad OATP1B1, OAT1, OAT3, OAT4 og OCT1 ved klinisk relevante plasmakoncentrationer.
English: Thiazide diuretics
Danish: Thiaziddiuretika
English: Female patients of childbearing potential should not rely on hormonal contraception alone when taking Zurampic (see sections 4.4 and 4.5).
Danish: Kvindelige patienter i den fertile alder bør ikke stole på hormonel prævention alene, når de tager Zurampic (se pkt.
English: Monitor for decreased efficacy when Zurampic is co-administered with a CYP2C9 inducer.
Danish: Der skal monitoreres for nedsat effekt, når Zurampic administreres sammen med en CYP2C9-induktor.
English: Epoxide hydrolase inhibitors
Danish: Epoxidhydrolasehæmmere
English: Proportion of patients who met serum uric acid Target (<5.0 mg/dL) N(%)
Danish: Andel af patienter, som opfyldte målet for serumurinsyre (<5,0 mg/dl) N (%)
English: Renal-related adverse reactions were reported in patients treated with Zurampic 200 mg (5.7%) and Zurampic 400 mg (11.8%) compared to placebo (4.5%), resulting in discontinuation of treatment in 1.2%, 3.3% and 1%, respectively (see section 4.4).
Danish: Der blev rapporteret nyrerelaterede bivirkninger hos 5,7% af patienterne på Zurampic 200 mg og hos 11,8 % af patienterne på Zurampic 400 mg sammenlignet med 4,5% af placebo-patienterne, hvilket resulterede i behandlingsafbrydelse hos hhv. 1,2 %, 3,3 % og 1 % (se pkt.
English: In both studies, significantly more patients treated with Zurampic 200 mg in combination with allopurinol achieved the target serum uric acid level of less than 6 mg/dL by Month 6 and by Month 12 compared with patients receiving placebo in combination with allopurinol (see Table 2).
Danish: I begge studier var der betydeligt flere patienter, der blev behandlet med Zurampic 200 mg i kombination med allopurinol, som nåede målniveauet for serumurinsyre på under 6 mg/dl ved Måned 6 og ved Måned 12 sammenlignet med patienter, der fik placebo i kombination med allopurinol (se Tabel 2).
English: Zurampic must always be taken together with your morning dose of either allopurinol or febuxostat.
Danish: Du skal altid tage Zurampic sammen med din morgendosis af enten allopurinol eller febuxostat.
English: In the randomised, double-blind, placebo-controlled combination therapy clinical studies, the incidences of patients with adjudicated Major Adverse Cardiovascular Events (CV death, non-fatal myocardial infarction or non-fatal stroke) per 100 patient-years of exposure were: 0.71 (95% CI 0.23, 2.21) for placebo, 0.96 (95% CI 0.36, 2.57) for Zurampic 200 mg, and 1.94 (95% CI 0.97, 3.87) for Zurampic 400 mg, when used in combination with a xanthine oxidase inhibitor.
Danish: I de randomiserede, dobbeltblinde, placebokontrollerede kliniske studier med kombinationsbehandling var forekomsten af patienter med vurderede alvorlige kardiovaskulære bivirkninger (Major Adverse Cardiovascular Events) (kardiovaskulær død, ikke-dødelig myokardieinfarkt eller ikke-dødelig apopleksi) pr. 100 patient-ekponeringsår: 0,71 (95 % KI 0,23-2,21) for placebo, 0,96 (95 % KI 0,362,57) for Zurampic 200 mg og 1,94 (95 % KI 0,97-3,87) for Zurampic 400 mg ved kombination med en xanthinoxidasehæmmer.
English: Renal failure** Renal impairment Nephrolithiasis
Danish: Nedsat nyrefunktion Nefrolitiasis
English: Metabolites are not known to contribute to the uric acid lowering effects of lesinurad.
Danish: Så vidt vides bidrager metabolitterne ikke til lesinurads urinsyresænkende effekt.
English: Consistent serum uric acid lowering was observed in patients who were receiving low dose acetylsalicylic acid in the placebo-controlled clinical studies in combination with allopurinol or febuxostat.
Danish: Der blev observeret konsistent reduktion af serumurinsyre hos patienter, som fik en lav dosis acetylsalicylsyre i kombination med allopurinol eller febuxostat i de placebokontrollerede kliniske studier.
English: No dose adjustment is necessary based on age (see section 5.2); however, elderly patients are more likely to have decreased renal function (see dosing recommendations for renal impairment).
Danish: 5.2), men der er større risiko for, at ældre patienter har nedsat nyrefunktion (se doseringsanbefalinger for nedsat nyrefunktion).
English: Based on these studies, Zurampic is only recommended at a dose of 200 mg once daily in combination with a xanthine oxidase inhibitor (see sections 4.2 and 4.4).
Danish: Baseret på disse studier anbefales det kun at give Zurampic i en dosis på 200 mg én gang dagligt i kombination med en xanthinoxidasehæmmer (se pkt.
English: Lesinurad exposure is increased when it is co-administered with inhibitors of CYP2C9.
Danish: Lesinurad-eksponering øges, når det administreres sammen med CYP2C9-hæmmere.
English: (200 mg) in patients with mild renal impairment (eCrCL 60 to 89 mL/min), 20% and 73% higher (200 mg) and 3% and 50% higher (400 mg) in patients with moderate renal impairment (eCrCL 30 to 59 mL/min), and 13% higher and 113% higher (400 mg) in patients with severe renal impairment (eCrCL <30 mL/min).
Danish: Efter administration af en enkelt dosis lesinurad til personer med nedsat nyrefunktion var henholdsvis lesinurad-Cmax og -AUC 36 % og 30 % højere (200 mg) hos patienter med let nedsat nyrefunktion (eCrCL 60-89 ml/min), 20 % og 73 % højere (200 mg) og 3 % og 50 % højere (400 mg) hos patienter med moderat nedsat nyrefunktion (eCrCL 30-59 ml/min) og 13 % højere og 113 % højere (400 mg) hos patienter med svært nedsat nyrefunktion (eCrCL <30 ml/min), sammenlignet med personer med normal nyrefunktion.
English: Lesinurad, when combined with a xanthine oxidase inhibitor, increases uric acid excretion and decreases uric acid production resulting in greater sUA lowering.
Danish: Når lesinurad kombineres med en xanthinoxidasehæmmer, øges udskillelsen af urinsyre og produktionen af urinsyre nedsættes, hvilket resulterer i større sUA-sænkning.