FrancophonIA/ELRC3.0 huggingface dataset:
English: Healthcare professionals must educate patients so they understand and acknowledge all the conditions of the Odomzo Pregnancy Prevention Programme.
Slovenian: Zdravstveni delavci morajo bolnike ustrezno poučiti, tako da ti razumejo in sprejmejo pogoje Programa preprečevanja nosečnosti pri uporabi zdravila Odomzo.
English: Laboratory test
Slovenian: Laboratorijska preiskava
English: Unchanged sonidegib in faeces represented 88.7% of the administered dose and was not detectable in urine.
Slovenian: Nespremenjen sonidegib v blatu je predstavljal 88,7 % danega odmerka, v urinu pa ga ni bilo mogoče zaznati.
English: Some medicines (e.g. medicines used to treat high cholesterol) might increase the risk for muscle problems.
Slovenian: Nekatera zdravila (na primer zdravila za zniževanje previsoke ravni holesterola) lahko povečajo tveganje za težave z mišicami.
English: Sonidegib is primarily metabolised by CYP3A4.
Slovenian: Sonidegib se primarno presnavlja s CYP3A4.
English: • at least 7 days before starting treatment - to make sure that you are not already pregnant
Slovenian: • v času najmanj 7 dni pred začetkom zdravljenja - da se prepričate, da niste že noseči, • v času zdravljenja enkrat na mesec.
English: Longer concomitant treatment with inducer is not recommended because sonidegib exposure will be decreased and this may compromise efficacy.
Slovenian: Dolgotrajnejše sočasno zdravljenje z induktorjem ni priporočeno, saj bi zmanjšalo izpostavljenost sonidegibu, to pa bi zmanjšalo njegovo učinkovitost.
English: As part of the Odomzo Pregnancy Prevention Programme, all patients will receive a:
Slovenian: V okviru Programa preprečevanja nosečnosti pri uporabi zdravila Odomzo bodo vsi bolniki prejeli:
English: • She must be able to comply with effective contraceptive measures.
Slovenian: • mora biti sposobna uporabljati učinkovite kontracepcijske metode,
English: Patient-reported outcomes were evaluated as an exploratory endpoint using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and its associated head and neck cancer specific module (H&N35).
Slovenian: Izide po navedbah bolnikov so vrednotili kot raziskovalni cilj opazovanja s pomočjo vprašalnika European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) in z njim povezanega specifičnega modula za raka glave in vratu (H&N35).
English: Effect of age, weight and gender
Slovenian: Vpliv starosti, telesne mase in spola
English: Pregnancy tests should have a minimum sensitivity of 25 mIU/ml as per local availability.
Slovenian: Izbrati je treba lokalno dostopen nosečnosti test z občutljivostjo vsaj 25 mi.e./ml.
English: Effects of sonidegib on other medicinal products
Slovenian: Učinki sonidegiba na druga zdravila
English: The European Medicines Agency has waived the obligation to submit the results of studies with Odomzo in all subsets of the paediatric population in basal cell carcinoma (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij z zdravilom Odomzo za vse podskupine pediatrične populacije z bazalnoceličnim karcinomom (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Each pack contains either 10 or 30 hard capsules.
Slovenian: Eno pakiranje vsebuje bodisi 10 ali 30 trdih kapsul.
English: • abnormal hair growth
Slovenian: • nenormalna rast dlak
English: Based on the available data, sonidegib elimination via the kidney is negligible.
Slovenian: Po podatkih, ki so na voljo, je izločanje sonidegiba skozi ledvice zanemarljivo.
English: If dose reduction is required, then the dose should be reduced to 200 mg every other day.
Slovenian: Če je potrebna sprememba odmerjanja, je treba odmerjanje znižati na 200 mg vsak drugi dan.
English: There are no data on the use of sonidegib in pregnant women.
Slovenian: Podatkov o uporabi sonidegiba pri nosečnicah ni.
English: Very common * Based on worst laboratory value post-treatment regardless of baseline, grading by CTCAE version 4.03
Slovenian: * glede na najslabšo laboratorijsko vrednost po zdravljenju ne glede na izhodiščno vrednost; ocenjevanje izraženosti po kriterijih CTCAE različica 4.03
English: Women of childbearing potential must be able to comply with effective contraceptive measures.
Slovenian: Ženske v rodni dobi morajo biti sposobne uporabljati učinkovite kontracepcijske metode.
English: Grade 2 without renal impairment
Slovenian: 2. stopnja brez okvare ledvic
English: Any capsules that remain unused at the end of treatment should immediately be disposed of by the patient in accordance with local requirements (e.g. by returning the capsules to their pharmacist or physician).
Slovenian: Neuporabljene kapsule, ki ostanejo po koncu zdravljenja, morajo bolniki takoj zavreči v skladu z lokalnimi predpisi (na primer tako, da jih vrnejo farmacevtu ali zdravniku).
English: • Swallow the capsule whole.
Slovenian: • Kapsulo pogoltnite celo.
English: There was reduced fertility at low exposure in female rats.
Slovenian: Pri nizki izpostavljenosti so opažali zmanjšano plodnost pri podganjih samicah.
English: What Odomzo is and what it is used for
Slovenian: Kaj je zdravilo Odomzo in za kaj ga uporabljamo
English: To avoid potential foetal exposure during pregnancy, a male patient must understand that:
Slovenian: Da ne bi povzročil izpostavljenosti ploda zdravilu med nosečnostjo, se mora moški bolnik zavedati, da:
English: Warnings and precautions - Odomzo may cause muscle problems.
Slovenian: Opozorila in previdnostni ukrepi - Zdravilo Odomzo lahko povzroča težave z mišicami.
English: Odomzo must be taken at least two hours after a meal and at least one hour before the following meal to prevent increased risk of adverse events due to higher exposure of sonidegib when taken with a meal (see section 5.2).
Slovenian: Zdravilo Odomzo je treba vzeti najmanj dve uri po obroku in najmanj eno uro pred naslednjim obrokom, s čimer je mogoče preprečiti povečano tveganje za neželene učinke, do katerih bi lahko prišlo zaradi večje izpostavljenosti sonidegibu pri jemanju skupaj z obrokom (glejte poglavje 5.2).
English: The toxicity of sonidegib as observed in studies C2301 and X2104 in adults was in line with the already known treatment related toxicity reported in adult patients with basal cell carcinoma.
Slovenian: Toksičnost sonidegiba, ugotovljena v študijah C2301 in X2104, je bila pri odraslih v skladu s predhodno znano toksičnostjo, povezano z zdravljenjem , ugotovljeno pri odraslih bolnikih z bazalnoceličnim karcinomom.
English: • The need to tell patients to report immediately to the treating healthcare professional if pregnancy is suspected in a female patient, or in a female partner of a male patient
Slovenian: • zahtevo po opozarjanju bolnikov, naj takoj obvestijo svojega lečečega zdravnika, če gre za sum na nosečnost pri bolnici ali pri partnerki moškega bolnika
English: Read the specific instructions given to you by your doctor, particularly on the effects of Odomzo on unborn babies.
Slovenian: Preglejte posebna navodila, ki vam jih je dal vaš zdravnik, zlasti tista, ki zadevajo vpliv zdravila Odomzo na nerojene otroke.
English: • severe itching of the skin, with a red rash or raised bumps.
Slovenian: • hudo srbenje kože z rdečim izpuščajem ali oteklinami.
English: All patients starting therapy with Odomzo must be informed of the risk of muscle-related adverse events, including the possibility of rhabdomyolysis.
Slovenian: Vse bolnike, ki začenjajo zdravljenje z zdravilom Odomzo, je treba obvestiti o tveganju za pojav z mišicami povezanih neželenih dogodkov, ki lahko vključujejo tudi rabdomiolizo.
English: • Methodology to collect information on the use of Odomzo and the compliance with the pregnancy pharmacovigilance programme and its effectiveness
Slovenian: • o metodologiji zbiranja informacij o uporabi zdravila Odomzo in o ravnanju skladno s farmakovigilančnim programom preprečevanja nosečnosti ter učinkovitosti tega programa,
English: It binds to Smoothened (Smo), a G protein-coupled receptor-like molecule that positively regulates the Hh pathway and eventually activates and releases glioma-associated oncogene (GLI) transcription factors which induces the transcription of Hh target genes involved in proliferation, differentiation and survival.
Slovenian: Veže se na protein Smoothened (Smo), ki je receptorju podobna molekula, združena z G-proteinom, njena naloga pa je pozitivna regulacija signalne poti Hh, kar vodi v aktivacijo in sproščanje transkripcijskih dejavnikov z gliomi povezanega onkogena (angl. glioma-associated oncogene, GLI), to pa inducira transkripcijo ciljnih genov signalne poti Hh, ki so vpleteni v proliferacijo, diferenciacijo in preživetje.
English: • high levels of the following enzymes: creatine phosphokinase (muscle function), lipase and/or amylase
Slovenian: • zvišane vrednosti naslednjih encimov: kreatin-kinaza (delovanje mišic), lipaza in/ali amilaza
English: Patients should be closely monitored and dose adjustments should be considered if muscle symptoms develop.
Slovenian: Bolnike je treba skrbno spremljati in v primeru razvoja mišičnih simptomov razmisliti o prilagajanju odmerka.
English: • She must tell her healthcare provider if any of the following occur during treatment and during the 20 months after her final dose: o she becomes pregnant or thinks for any reason that she may be pregnant, o she misses her expected menstrual period, o she stops using contraception unless she commits to not having sexual intercourse (abstinence), o she needs to change contraception.
Slovenian: • mora svojega zdravnika obvestiti, če v času zdravljenja in v 20 mesecih po zadnjem odmerku pride do česarkoli od naslednjega: o če zanosi ali iz kakršnegakoli razloga domneva, da je noseča, o če ji izostane pričakovana menstruacija, o če preneha uporabljati kontracepcijo, razen če se vnaprej odpove spolnim odnosom, o če mora zamenjati kontracepcijo,
English: The safety and efficacy of Odomzo in children and adolescents aged below 18 years with basal cell carcinoma have not been established.
Slovenian: Varnost in učinkovitost zdravila Odomzo pri otrocih in mladostnikih z bazalnoceličnim karcinomom, starih do 18 let, nista bili dokazani.
English: Criteria defining a woman of childbearing potential
Slovenian: Kriteriji, ki opredeljujejo žensko v rodni dobi
English: Odomzo is contraindicated during pregnancy.
Slovenian: Zdravilo Odomzo je med nosečnostjo kontraindicirano.
English: Studies in animals have shown teratogenicity and foetotoxicity (see section 5.3).
Slovenian: Študije na živalih so pokazale teratogeno in fetotoksično delovanje (glejte poglavje 5.3).
English: All the metabolites were deemed 4 to 90 times less potent than sonidegib.
Slovenian: Vsi presnovki so domnevno 4-krat do 90-krat šibkejši od sonidegiba.
English: The bioavailability of sonidegib is increased in the presence of food (see section 5.2).
Slovenian: V prisotnosti hrane se biološka uporabnost sonidegiba poveča (glejte poglavje 5.2).
English: Grade 3 or 4 without renal impairment
Slovenian: 3. ali 4. stopnja brez okvare ledvic
English: Each hard capsule contains 38.6 mg lactose monohydrate.
Slovenian: Ena trda kapsula vsebuje 38,6 mg laktoze monohidrata.
English: The CTCAE is a standardised classification of side effects used in assessing medicinal products for cancer therapy.
Slovenian: Klasifikacija CTCAE je standardizirana klasifikacija neželenih učinkov, s pomočjo katerih ocenjujemo zdravila, ki jih uporabljamo pri zdravljenju raka.
English: Read carefully and follow the instructions of the patient brochure and reminder card given to you by your doctor.
Slovenian: Skrbno preglejte in upoštevajte navodila v gradivu, ki vam ga je dal vaš zdravnik: v knjižici za bolnike in na opozorilni kartici za bolnike.
English: If symptoms persist despite alternate-day dosing, consider discontinuing treatment.
Slovenian: Če simptomi vztrajajo kljub odmerjanju vsak drugi dan, razmislite o ukinitvi zdravila.
English: Concomitant treatment with strong CYP inducers (e.g. rifampicin, carbamazepine or phenytoin) should be avoided, as a risk for decreased plasma concentrations and decreased efficacy of sonidegib cannot be excluded (see also section 4.5).
Slovenian: Sočasnemu zdravljenju z močnimi induktorji CYP (na primer z rifampicinom, karbamazepinom ali fenitoinom) se je treba izogibati, saj ni mogoče izključiti možnosti, da bi to znižalo koncentracijo sonidegiba v plazmi in zmanjšalo njegovo učinkovitost (glejte tudi poglavje 4.5).
English: In patients with basal cell carcinoma, changes occur to genes controlling a part of this process known as the “hedgehog pathway”.
Slovenian: Pri bolnikih z bazalnoceličnim karcinomom pride do spremembe v genih, ki nadzorujejo tisti del tega procesa, ki ga imenujemo “signalna pot hedgehog”.
English: If the patient does become pregnant, misses a menstrual period, or suspects for any reason that she may be pregnant, she must notify her treating physician immediately.
Slovenian: Če ženska zanosi, ji izostane menstruacija ali iz kateregakoli razloga meni, da bi bila lahko noseča, mora takoj obvestiti lečečega zdravnika.
English: A woman of childbearing potential must understand that:
Slovenian: Ženska v rodni dobi se mora zavedati, da:
English: FAS: Full analysis set
Slovenian: FAS: skupina bolnikov za celotno analizo (angl. full analysis set) IZ: interval zaupanja
English: MRI tumour response was evaluated by RECIST 1.1.
Slovenian: posnetkih so ocenjevali po kriterijih RECIST 1.1.
English: The capsules must not be opened due to risk of teratogenicity (see section 5.3).
Slovenian: Kapsul se ne sme odpirati zaradi tveganja za teratogeno delovanje (glejte poglavje 5.3).
English: Dose modification or interruption guidelines should be followed (see section 4.2).
Slovenian: Upoštevati je treba priporočila za znižanje ali prekinitev odmerjanja (glejte poglavje 4.2).
English: • does not have a XY genotype, Turner's syndrome or uterine agenesis,
Slovenian: • nima genotipa XY, Turnerjevega sidroma ali agenezije maternice,
English: • high level of sugar in the blood (known as hyperglycaemia)
Slovenian: • zvišana vrednost sladkorja v krvi (kar imenujemo hiperglikemija),
English: Sonidegib is an orally bioavailable inhibitor of the Hh signalling pathway.
Slovenian: Sonidegib je peroralno biološko uporaben zaviralec signalne poti Hh.
English: • Do not eat for 2 hours before taking Odomzo and for 1 hour afterwards.
Slovenian: • Ne uživajte hrane 2 uri pred jemanjem zdravila Odomzo in 1 uro po tem.
English: to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Slovenian: Pri tem ustrezna kategorija pogostnosti posameznega neželenega učinka temelji na naslednjem dogovoru (CIOMS III): zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: Odomzo must be taken at least two hours after a meal and at least one hour before the following meal.
Slovenian: Zdravilo Odomzo je treba jemati najmanj dve uri po obroku in najmanj eno uro pred naslednjim obrokom.
English: Safety and efficacy data in patients aged 65 years and older do not suggest that a dosage adjustment is required in these patients (see section 5.2).
Slovenian: Podatki o varnosti in učinkovitosti uporabe zdravila pri bolnikih, ki so stari 65 let ali več, ne kažejo, da bi bilo pri teh bolnikih treba odmerjanje zdravila prilagajati (glejte poglavje 5.2).
English: Odomzo should only be prescribed by or under the supervision of a specialist physician experienced in the management of the approved indication.
Slovenian: Zdravljenje z zdravilom Odomzo sme predpisati in nadzorovati samo zdravnik specialist, ki ima izkušnje z zdravljenjem odobrene indikacije.
English: Time to deterioration in the pre-specified PRO scales (corresponding to >10-point worsenings without subsequent improvement) essentially mirrored the estimated PFS.
Slovenian: Čas do poslabšanja ocene na lestvicah izidov po navedbah bolnikov v vnaprej opredeljenem obsegu (ki je poslabšanje ocene za več kot 10 točk brez kasnejšega izboljšanja) se je v bistvu ujemal z ocenjenim časom preživetja brez napredovanja bolezni.
English: • The format and content of the Healthcare professional and patient material
Slovenian: • o obliki in vsebini izobraževalnega gradiva za zdravstvene delavce in za bolnike.
English: The recommended dose is 200 mg sonidegib taken orally once daily at least two hours after a meal and at least one hour before the following meal, at the same time each day.
Slovenian: Priporočeni odmerek je 200 mg sonidegiba peroralno enkrat na dan vsak dan ob istem času, in sicer najmanj dve uri po obroku in najmanj eno uro pred naslednjim obrokom.
English: Do not take Odomzo if you are pregnant, think you may be pregnant, or are planning to become pregnant during your treatment or during the 20 months after your treatment has finished.
Slovenian: Ne jemljite zdravila Odomzo, če ste noseči, menite, da bi lahko bili noseči, ali načrtujete zanositev v času zdravljenja ali v obdobju 20 mesecev po zaključku zdravljenja.
English: Sonidegib and its metabolites are eliminated primarily by the hepatic route with 93.4% of the administered dose recovered in the faeces and 1.95% recovered in urine.
Slovenian: Sonidegib in njegovi presnovki se večinoma izločajo preko jeter, pri čemer so 93,4 % danega odmerka prestregli v blatu, 1,95 % pa v urinu.
English: Odomzo contains lactose (milk sugar).
Slovenian: Zdravilo Odomzo vsebuje laktozo (mlečni sladkor).
English: Odomzo is provided in perforated unit-dose blisters containing 10 x 1 capsule.
Slovenian: Zdravilo Odomzo je pakirano v perforiranih pretisnih omotih z razdelki za enkratni odmerek, ki vsebujejo 10 x 1 kapsulo.
English: Steady-state level of sonidegib in the skin was 6-fold higher than in plasma.
Slovenian: V stanju dinamičnega ravnovesja je bila koncentracija sonidegiba v koži 6-krat višja kot v plazmi.
English: (pancreas function), alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) (liver function)
Slovenian: (delovanje trebušne slinavke), alanin-aminotransferaza (ALT) in/ali aspartat-aminotransferaza (AST)
English: Odomzo capsules contain lactose monohydrate.
Slovenian: Kapsule zdravila Odomzo vsebujejo laktozo monohidrat.
English: Response by digital clinical photograph was evaluated by World Health Organization (WHO) adapted criteria [partial response (PR): ≥50% decrease in the sum of the product of perpendicular diameters (SPD) of a lesion; complete response (CR): disappearance of all lesions; progressive disease: ≥25% increase in the SPD of lesions].
Slovenian: Odziv na digitalnih kliničnih fotografijah so ocenjevali po prilagojenih kriterijih Svetovne zdravstvene organizacije [delni odziv (partial response, PR): ≥50-odstotno zmanjšanje vsote produktov dveh pravokotnih premerov posameznih lezij; popoln odziv (complete response, CR): izginotje vseh lezij; napredovanje bolezni: ≥25-odstotno povečanje vsote produktov dveh pravokotnih premerov posameznih lezij].
English: It is available in pack sizes of 10 and 30 capsules.
Slovenian: Na voljo je v pakiranjih po 10 oziroma 30 kapsul.
English: Sonidegib was shown to be foetotoxic in rabbits, as evidenced by abortion and/or complete resorption of foetuses and teratogenic resulting in severe malformations at very low exposure.
Slovenian: Pokazalo se je, da sonidegib pri kuncih deluje fetotoksično, kar dokazujejo splavi in/ali popolna resorpcija plodov, in teratogeno, kar povzroči hude razvojne nepravilnosti že pri zelo nizki izpostavljenosti.
English: • She must have a negative pregnancy test, conducted by a healthcare professional within 7 days before starting Odomzo treatment.
Slovenian: • mora imeti negativen izvid nosečnostnega testa, ki ji ga izvede zdravstveni delavec v roku 7 dni pred začetkom zdravljenja z zdravilom Odomzo,
English: If you take more Odomzo than you should, or if someone else accidentally takes your medicine, talk to a doctor or go to a hospital straight away.
Slovenian: Če ste vzeli večji odmerek zdravila Odomzo, kot bi smeli Če vzamete več zdravila Odomzo, kot bi smeli, ali če kdo drug pomotoma vzame vaše zdravilo, se takoj posvetujte z zdravnikom ali se odpravite v bolnišnico.
English: Carcinogenicity studies have not been performed with sonidegib, but sonidegib was not genotoxic in studies conducted in vitro and in vivo.
Slovenian: S sonidegibom niso izvedli študij kancerogenosti, vendar sonidegib v študijah, ki so izvajali in vitro in in vivo, ni deloval genotoksično.
English: Prescriptions of Odomzo should be limited to 30 days of treatment, with continuation of treatment requiring a new prescription.
Slovenian: Posamezen recept za zdravilo Odomzo mora biti omejen na 28 dni zdravljenja, za nadaljnje zdravljenje pa je potreben nov recept.
English: It is used when the cancer has spread locally and cannot be treated with surgery or radiation.
Slovenian: Zdravilo uporabljamo, če se je rak razširil na mestu (lokalno) in ga ne moremo zdraviti z operacijo ali obsevanjem.
English: In the phase II pivotal study, muscle spasms, myalgia, myopathy and cases of CK elevations were observed.
Slovenian: V ključni študiji faze II so opažali mišične spazme, mialgijo, miopatijo in primere zvišanja vrednosti kreatinkinaze.
English: Objective response rate, n (%) 95% CI Best overall response, n (%) Complete response
Slovenian: 95-odstotni IZ najboljši dosežen odziv, n (%)
English: Odomzo is not likely to affect your ability to drive or use any tools or machines.
Slovenian: Zdravilo Odomzo po vsej verjetnosti ne vpliva na sposobnost vožnje, uporabe orodja in upravljanja strojev.
English: Odomzo works by blocking this process, stopping cancer cells from growing and making new cells.
Slovenian: Zdravilo Odomzo deluje tako, da blokira ta proces in zavira rast in razmnoževanje rakavih celic.
English: Patients concomitantly using substrates of BCRP transporters should be carefully monitored for adverse drug reactions.
Slovenian: Pri bolnikih, ki sočasno uporabljajo substrate prenašalcev BCRP, je treba skrbno spremljati morebitno pojavljanje neželenih učinkov.
English: What you need to know before you take Odomzo
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Odomzo
English: Patients with neuromuscular disorders (e.g. inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal muscular atrophy) must be closely monitored due to an increased risk of muscle toxicity.
Slovenian: Posebej skrbno je treba spremljati bolnike z živčno-mišičnimi boleznimi (kot so vnetne miopatije, mišična distrofija, amiotrofična lateralna skleroza, spinalna mišična atrofija) zaradi povečanega tveganja za toksično delovanje na mišice.
English: Women of childbearing potential whose periods are irregular or have stopped must follow all the advice on effective contraception.
Slovenian: Tudi tiste ženske v rodni dobi, ki imajo neredne menstruacije ali izgubijo menstruacijo, se morajo držati vseh priporočil glede učinkovite kontracepcije.
English: During Odomzo treatment, you may also have some abnormal blood test results.
Slovenian: V času zdravljenja z zdravilom Odomzo so lahko izvidi nekaterih krvnih preiskav nenormalni.
English: Based on a population pharmacokinetic analysis of 351 patients who received oral doses of Odomzo in the dose range of 100 mg to 3000 mg, the apparent steady-state volume of distribution (Vss/F) was 9170 litres.
Slovenian: Porazdelitev Po podatkih populacijske farmakokinetične analize pri 351 bolnikih, ki so prejemali peroralne odmerke zdravila Odomzo v višini od 100 mg do 3.000 mg, je navidezni volumen porazdelitve v stanju dinamičnega ravnovesja (Vss/F) znašal 9.170 litrov.
English: • muscle cramps, muscle pain, pain in the bones, ligaments and tendons
Slovenian: • mišični krči, bolečine v mišicah, bolečine v kosteh, sklepnih vezeh in kitah