FrancophonIA/ELRC3.0 huggingface dataset:
English: Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product
Croatian: Lijek se izdaje na ograničeni recept (vidjeti Prilog I.: Sažetak opisa svojstava lijeka, dio 4.2).
English: D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE
Croatian: UVJETI ILI OGRANIČENJA VEZANI UZ SIGURNU I
English: Name and address of the manufacturer(s) of the biological active substance(s) Therapure Biopharma Inc.
Croatian: Naziv(i) i adresa(e) proizvođača biološke(ih) djelatne(ih) tvari
English: The vials should be used immediately and no longer than 3 hours after reconstitution.
Croatian: Bočice treba upotrijebiti odmah i najviše 3 sata nakon rekonstitucije.
English: Prior to launch in any EU Member State, the MAH will set up an immunosurveillance programme and provide antibody testing for anti-ATryn antibodies to physicians.
Croatian: Do datuma imunološkog praćenja i liječnicima omogućiti provedbu pretraga na antitijela za antitijela na lijek ATryn.
English: c)
Croatian: NN:
English: 6.6 Special precautions for disposal and other handling
Croatian: 6.4 Posebne mjere pri čuvanju lijeka
English: One vial contains nominally 1750 IU* antithrombin alfa**.
Croatian: KVALITATIVNI I KVANTITATIVNI SASTAV Jedna bočica nominalno sadrži 1750 IU* antitrombina alfa**.
English: Post procedural haemorrhage Wound secretion
Croatian: Tabelarni prikaz nuspojava
English: Your treatment will be initiated under the supervision of a physician experienced in the care of patients with Your health care provider will prepare a solution of antithrombin alfa to be administered to you through your vein.
Croatian: Vaše liječenje će započeti pod nadzorom liječnika s iskustvom u liječenju bolesnika s urođenim nedostatkom antitrombina.
English: Common
Croatian: Francuska
English: Package leaflet: Information for the user ATryn 1750 IU powder for solution for infusion antithrombin alfa (rDNA) This medicine is subject to additional monitoring.
Croatian: ATryn 1750 IU prašak za otopinu za infuziju antitrombin alfa (rDNK)
English: What ATryn looks like and contents of the pack
Croatian: Što ATryn sadrži
English: • dizziness
Croatian: • Doziranje
English: Detailed information on this product is available on the website of the European Medicines Agency
Croatian: Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu.
English: Adverse reactions
Croatian: Reakcije preosjetljivosti
English: Due date reaction or lack of efficacy.
Croatian: • Nuspojave lijeka uključujući izostanak djelotvornosti
English: MedDRA SOC
Croatian: ZA de Courtaboeuf
English: Marketing Authorisation Holder and Manufacturer
Croatian: NOSITELJ ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET
English: Gastrointestinal disorders
Croatian: • Primjena antikoagulansa
English: associated with cough and fever),
Croatian: NAVOĐENJE DJELATNE(IH) TVARI
English: These signs may be:
Croatian: Ti znakovi mogu biti:
English: 4- Repeat this cleaning process 3 times.
Croatian: 4- Ponovite taj postupak čišćenja 3 puta.
English: 2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Croatian: 2 KVALITATIVNI I KVANTITATIVNI SASTAV
English: • one in late afternoon
Croatian: • jednom u kasno poslijepodne
English: Be careful, do not push the plunger in during this step.
Croatian: Budite pažljivi kako pri ovom koraku ne biste pritisnuli klip štrcaljke.
English: Your doctor will advise you on whether you need to stop breastfeeding or not.
Croatian: Vaš liječnik će Vas savjetovati o tome trebate li prekinuti dojenje ili ne.
English: Never change the dose you are giving to your child yourself.
Croatian: Nikada sami ne mijenjajte dozu koju dajete svom djetetu.
English: Combinations should consider the 2 following situations (not mutually exclusive):
Croatian: U sljedeće dvije situacije moraju se uzeti u obzir kombinacije (nisu međusobno isključive):
English: • This medicine has been prescribed for your child only.
Croatian: • Ovaj je lijek propisan samo za Vaše dijete.
English: Please check with your doctor if you are not sure.
Croatian: Molimo provjerite sa svojim liječnikom ako niste sigurni.
English: AV block
Croatian: AV blok
English: This leaflet was last revised in. Other sources of information
Croatian: Ova uputa je zadnji puta revidirana u Ostali izvori informacija
English: • The need to monitor and to contact the healthcare professionals if the following signs and symptoms occur after treatment:
Croatian: • Potrebu da se nadzire i obavijesti zdravstvene radnike ako se pojave sljedeći znakovi i simptomi nakon liječenja:
English: • one in the morning
Croatian: • jednom ujutro
English: Appropriate monitoring of the child is required until symptoms disappear.
Croatian: Potrebno je odgovarajuće pratiti stanje djeteta sve dok simptomi ne nestanu.
English: Due to the clinical trial database size rare and very rare categories are not represented.
Croatian: Zbog veličine baze podataka kliničkih ispitivanja, rijetke i vrlo rijetke kategorije nisu prikazane.
English: Specialised advice should be sought.
Croatian: Mora se zatražiti savjet specijalista.
English: Close the bottle.
Croatian: Zatvorite bocu
English: • Heart failure not controlled by treatment
Croatian: • Zatajenje srca koje nije kontrolirano liječenjem
English: After first opening: 2 months.
Croatian: Nakon prvog otvaranja: 2 mjeseca.
English: Haemangioma can be superficial or deep.
Croatian: Hemangiom može biti površinski ili duboki.
English: 9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Croatian: 9 DATUM PRVOG ODOBRENJA/DATUM OBNOVE ODOBRENJA
English: Discontinuation of treatment does not require a progressive decrease in the dose.
Croatian: Prekid liječenja ne zahtijeva progresivno smanjivanje doze.
English: • The medicine is to be given during or straight after a feed.
Croatian: • Lijek se treba dati tijekom ili odmah nakon hranjenja.
English: Always give this medicine to your child exactly as your doctor or pharmacist has told you.
Croatian: Uvijek dajte ovaj lijek svom djetetu točno onako kako su Vam rekli Vaš liječnik ili ljekarnik.
English: It is sometimes called ‘strawberry mark' because the surface of a haemangioma looks a bit like a strawberry.
Croatian: On se ponekad naziva „znak jagode“ jer površina hemangioma pomalo izgleda poput jagode.
English: Pull the plunger of the syringe up to the number of mg you need.
Croatian: Povlačite klip štrcaljke sve do broja mg koji Vam je potreban.
English: The percentage contributions of these routes to total metabolism are 42%, 41% and 17%, respectively, but with considerable variability between individuals.
Croatian: Postotni doprinosi tim putevima do ukupnog metabolizma su 42%, 41% i 17%, ali sa znatnom varijabilnošću između pojedinih doprinosa.
English: Therefore the need for treatment should be carefully weighed up.
Croatian: Stoga je potrebu za liječenjem potrebno pažljivo odvagnuti.
English: Other Central Nervous System disorders were principally observed during the early periods of treatment.
Croatian: Ostali poremećaji središnjeg živčanog sustava uglavnom su uočeni tijekom ranih perioda liječenja.
English: • Second- or third-degree atrioventricular blocks
Croatian: • Atrioventrikularni blokovi drugog ili trećeg stupnja
English: It is to be initiated in infants aged 5 weeks to 5 months (see section 4.2).
Croatian: Primjenu treba započeti kod dojenčadi u dobi od 5 tjedana do 5 mjeseci (vidjeti dio 4.2).
English: Based on a retrospective study, a minority of patients (12%) required a re-initiation of systemic treatment.
Croatian: Na temelju retrospektivnog ispitivanja, kod manjine bolesnika (12%) bilo je potrebno ponoviti sistemsko liječenje.
English: Do not mix the medicine with a full bottle of milk or juice.
Croatian: Ne miješajte lijek s punom bočicom mlijeka ili soka.
English: Automatism and conduction disorders are expected because of the suppression of sympathetic compensative mechanisms.
Croatian: Automatizam i poremećaji provodljivosti očekivani su zbog supresije simpatičkih kompenzacijskih mehanizama.
English: Continue the treatment at the usual frequency: one dose in the morning and one in the late afternoon.
Croatian: Nastavite s liječenjem prema uobičajenoj učestalosti: jedna doza ujutro i jedna doza kasno poslijepodne.
English: The advice of a cardiologist should be sought.
Croatian: Mora se zatražiti savjet kardiologa.
English: Like all medicines, this medicine can cause side effects, although not everybody gets them.
Croatian: Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave iako se one neće pojaviti kod svakoga.
English: Please refer to section 2 of this leaflet.
Croatian: Molimo pogledajte dio 2. ove upute.
English: Use the mixture within 2 hours of preparation.
Croatian: Potrošite mješavinu unutar 2 sata od pripreme.
English: The volume of distribution of propranolol is approximately 4 L/kg.
Croatian: Volumen distribucije propranolola iznosi približno 4 l/kg.
English: Interactions requiring precautions for use
Croatian: Interakcije koje zahtijevaju mjere opreza pri uporabi
English: The educational pack must be available for distribution prior to the launch of the new indication (treatment of proliferating infantile haemangioma) in the Member State.
Croatian: Edukacijski paket mora biti dostupan za distribuciju prije puštanja u promet nove indikacije (liječenje proliferirajućeg infantilnog hemangioma) u državi članici.
English: • Very low levels of white blood cells that fight infection
Croatian: • Vrlo niske razine bijelih krvnih stanica koje se bore protiv infekcije,
English: • the absence of cardioselective beta-1 beta-blocking activity,
Croatian: • nedostatak kardioselektivne aktivnosti beta-1 beta-blokatora,
English: This is because HEMANGIOL can change the way other medicines work, and some medicines can have an effect on the way HEMANGIOL works.
Croatian: Učinite to zato jer HEMANGIOL može promijeniti način na koji drugi lijekovi djeluju, a neki lijekovi mogu utjecati na način na koji djeluje HEMANGIOL.
English: • Tell your doctor, pharmacist or nurse if you are giving, have recently given or might give any other medicines to your child.
Croatian: • Obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako dajete, nedavno ste dali ili biste mogli svom djetetu davati bilo koje druge lijekove.
English: Do not use any soap or alcohol based product to clean.
Croatian: Za čišćenje nemojte koristiti nikakav sapun ili proizvod na bazi alkohola.
English: HEMANGIOL might need to be discontinued at least 48h before the anaesthesia.
Croatian: HEMANGIOL će možda trebati prestati uzimati najmanje 48 sati prije anestezije.
English: If your child should undergo a general anaesthesia
Croatian: Ako Vaše dijete mora biti podvrgnuto općoj anesteziji
English: Date of first authorisation: 23 April 2014 Date of latest renewal:
Croatian: Datum prvog odobrenja: 23. travnja 2014.
English: The name of your medicine is HEMANGIOL.
Croatian: Naziv Vašeg lijeka je HEMANGIOL.
English: 4 CLINICAL PARTICULARS 4.1 Therapeutic indications
Croatian: 4 KLINIČKI PODACI 4.1 Terapijske indikacije
English: Absorption and distribution:
Croatian: Apsorpcija i distribucija:
English: After the titration phase, the dose will be readjusted by the physician according to the changes in the child's weight.
Croatian: Nakon faze titracije, liječnik će ponovno podesiti dozu u skladu s promjenama težine djeteta.
English: Their frequency is defined using the following conventions: very common (≥ 1/10), common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000); not known (cannot be estimated from the available data).
Croatian: Njihova učestalost definirana je prema sljedećim kategorijama: vrlo često (≥ 1/10), često (≥ 1/100 i <1/10), manje često (≥ 1/1000 i <1/100), rijetko (≥ 1/10000 i <1/1000); vrlo rijetko (<1/10 000),
English: HEMANGIOL should be administered for a 6-month period.
Croatian: HEMANGIOL se treba primjenjivati tijekom 6 mjeseci.
English: • Step 5: Remove the dose
Croatian: • Korak 5. Izvucite dozu
English: This is why your child will be kept under close clinical and heart rate monitoring for 2 hours after the first dose or after a dose increase.
Croatian: Zbog toga će Vaše dijete biti pod strogim kliničkim nadzorom i praćenjem otkucaja srca tijekom 2 sata nakon primjene prve doze ili nakon povećanja doze.
English: 6-12 months
Croatian: 6-12 mjeseci
English: Both agents may induce hypotension and/or heart failure in patients whose cardiac function is partially controlled because of additive inotropic effects.
Croatian: Oba agensa mogu uzrokovati hipotenziju i/ili zatajenje srca kod bolesnika čija se srčana funkcija djelomično kontrolira zbog aditivnih inotropnih učinaka.
English: EXP After first opening, the medicine should be used within 2 months.
Croatian: EXP Nakon prvog otvaranja, lijek se mora upotrijebiti unutar 2 mjeseca.
English: • If your child has ever had an allergic reaction whatever its origin (e.g. medicine or alimentary substance etc.).
Croatian: • Ako je Vaše dijete ikada imalo alergijsku reakciju, bez obzira na njezin uzrok (lijek, tvar iz hrane itd.).
English: What HEMANGIOL is and what it is used for 2.
Croatian: Što je HEMANGIOL i za što se koristi 2.
English: • Agitation, nightmares, irritability,
Croatian: • Uznemirenost, noćne more, razdražljivost,
English: Clinical monitoring of the child condition, and dose readjustment, need to be performed at least monthly.
Croatian: Kliničko praćenje stanja djeteta i ponovno prilagođavanje doze mora se provoditi najmanje mjesečno.
English: The MAH must agree the content and format of the educational material, together with a communication plan, with the national competent authority prior to distribution of the educational pack.
Croatian: Nositelj odobrenja za stavljanje lijeka u promet mora dogovoriti sadržaj i oblik edukacijskih materijala, zajedno s komunikacijskim planom, s nadležnim nacionalnim tijelom prije distribucije edukacijskog paketa.
English: 6 Contents of the pack and other information What HEMANGIOL contains
Croatian: Sadržaj pakiranja i druge informacije Što HEMANGIOL sadrži
English: Administration of protein-rich foods increases the bioavailability of propranolol by about 50% with no change in time to peak concentration.
Croatian: Primjena hrane bogate proteinima povećava raspoloživost propranolola za oko 50%, bez promjene vremena postizanja vršne koncentracije.
English: Support and treatment:
Croatian: Potpora i liječenje:
English: The educational materials for caregivers treating children with HEMANGIOL should include the following key safety elements:
Croatian: Edukacijski materijali za pružatelje skrbi koji liječe djecu HEMANGIOL-om moraju uključivati sljedeće ključne sigurnosne elemente:
English: Biotransformation and elimination:
Croatian: Biotransformacija i izlučivanje:
English: In the absence of clinical efficacy and safety data, HEMANGIOL should not be used in infants aged below 5 weeks.
Croatian: U nedostatku podataka o kliničkoj djelotvornosti i sigurnosti, HEMANGIOL se ne smije koristiti kod dojenčadi mlađe od 5 tjedana.
English: Less than 1% of a dose is excreted as unchanged drug in the urine.
Croatian: Manje od 1% doze izlučuje se kao nepromijenjeni lijek u mokraći.
English: To avoid risks of hypoglycaemia, your child must be fed regularly during treatment.
Croatian: Kako biste izbjegli rizik od hipoglikemije, Vaše dijete mora redovito jesti tijekom liječenja.
English: CARTON BOX / BOTTLES NAME OF THE MEDICINAL PRODUCT
Croatian: KARTONSKA KUTIJA / BOCE NAZIV LIJEKA
English: If different people are involved, good communication is essential in order to ensure the safety of the child.
Croatian: Ako su u davanje uključene različite osobe, bitna je dobra komunikacija kako bi se osigurala sigurnost djeteta.
English: When a patient is scheduled for surgery, beta-blocker therapy should be discontinued at least 48 hours prior to the procedure.
Croatian: Kada bolesnik dobije termin za operaciju, terapija beta-blokatorom mora se prekinuti najmanje 48 sati prije zahvata.
English: In this case, the need of stopping breast-feeding should be discussed.
Croatian: U tom slučaju mora se razmotriti potreba za prestankom dojenja.
English: This combination must only be administered under close clinical and ECG monitoring, particularly at the start of the treatment.
Croatian: Ova kombinacija smije se primjenjivati jedino pod strogim kliničkim i EKG praćenjem, osobito na početku liječenja.
English: 11.4% of patients needed to be re-treated after treatment discontinuation.
Croatian: U 11,4% bolesnika nakon prekida liječenja bilo je potrebno ponoviti liječenje.
English: Skip the missed dose, and do not give a double dose to make up for a forgotten dose.
Croatian: Preskočite zaboravljenu dozu i nemojte mu davati dvostruku dozu kako biste nadoknadili zaboravljenu dozu.
English: Store the bottle and the syringe together in the carton until next use in a safe place where your child can't see or reach it.
Croatian: Čuvajte bocu i štrcaljku zajedno u kutiji do iduće uporabe na sigurnom mjestu, izvan pogleda i dohvata Vašeg djeteta.
English: Bradycardia is defined below the following limits:
Croatian: Bradikardija se definira za vrijednosti ispod sljedećih granica:
English: Concomitant use can increase the risk of bradycardia.
Croatian: Istodobna primjena može povećati rizik od bradikardije.
English: In the minority of patients showing a relapse of symptoms after treatment discontinuation, treatment may be re-initiated under the same conditions with a satisfactory response.
Croatian: Kod manjeg broja bolesnika kod kojih se vrate simptomi nakon prekida liječenja, liječenje se može ponovno započeti pod istim uvjetima uz zadovoljavajući odgovor.
English: The frequency of the following side effects is not known (frequency cannot be estimated from the available data)
Croatian: Učestalost sljedećih nuspojava nije poznata (učestalost se ne može procijeniti iz dostupnih podataka)
English: Do not put the syringe through a sterilizer or dishwasher.
Croatian: Ne stavljajte štrcaljku u sterilizator ili stroj za pranje posuđa.
English: The bottle should not be shaken before use.
Croatian: Bocu ne treba tresti prije uporabe.
English: Propranolol belongs to a group of medicines known as beta-blockers.
Croatian: Propranolol pripada skupini lijekova poznatih kao beta-blokatori.
English: The regimen 3 mg/kg/day during 6 months (selected at the end of the phase II part of the study) presented 60.4% of success versus 3.6% in the placebo arm (p value < 0.0001).
Croatian: Režim od 3 mg/kg/dan tijekom 6 mjeseci (odabran na kraju ispitivanja faze II) pokazao je uspješnost od 60,4% u odnosu na uspješnost od 3,6% u placebo skupini (p-vrijednost <0,0001).
English: This medicine will not be recommended in case of liver or kidneys impairment.
Croatian: Ovaj lijek se ne preporučuje u slučaju oštećenja jetre ili bubrega.
English: If you see air bubbles in the syringe, hold the syringe upright, push the plunger upwards just far enough to completely push out any large air bubbles and then readjust to the dose prescribed by your doctor.
Croatian: Ako u štrcaljki vidite mjehuriće zraka, držite štrcaljku uspravno, potisnite klip prema gore samo toliko koliko je potrebno da velike mjehuriće zraka u potpunosti istisnete, a zatim ponovno povucite do doze koju je propisao Vaš liječnik.
English: Although some data were equivocal, based on the overall available in vitro and in vivo data, it can be concluded that propranolol is devoid of genotoxic potential.
Croatian: Iako su neki podaci bili dvosmisleni, temeljem svih dostupnih in vitro i in vivo podataka, može se zaključiti da propranolol nema genotoksični potencijal.
English: The pharmacokinetic evaluation was performed at steady-state, after 1 or 3 months of treatment.
Croatian: Farmakokinetička procjena je provedena u stanju dinamičke ravnoteže, nakon 1 ili 3 mjeseca liječenja.
English: Age (35-90 days / 91150 days), gender and haemangioma location (head / body) subgroups did not identify differences in response to propranolol.
Croatian: (35 do 90 dana / 91 do 150 dana), spola i lokacije hemangioma (glava/tijelo) nisu pokazale razlike u odgovoru na propranolol.
English: Now you can slowly squirt HEMANGIOL from the syringe directly into your baby's mouth.
Croatian: Sada možete polako štrcati HEMANGIOL iz štrcaljke izravno u djetetova usta.
English: Agitation Nightmares Irritability
Croatian: Noćne more Razdražljivost
English: However, in the study conducted in juvenile animals treated all over the development period corresponding to infancy, childhood and adolescence, no effect on male and female fertilities was observed (See section 4.6).
Croatian: Međutim, u studiji provedenoj kod mladih životinja liječenih tijekom čitavog razdoblja koje odgovara djetinjstvu, dječjoj dobi i adolescenciji, nije bilo zabilježenih učinaka na mušku i žensku plodnost (vidjeti dio 4.6).
English: 0-3 months
Croatian: 0-3 mjeseci
English: • is allergic to propranolol or any of the other ingredients of this medicine (listed in section 6).
Croatian: • je Vaše dijete alergično na propranolol ili bilo koji drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: Approximately 90% of circulating propranolol is bound to plasma proteins (albumin and alpha1 acid glycoprotein).
Croatian: Oko 90% cirkulirajućeg propranolola veže se za proteine plazme (albumin i alfa-1 kiseli glikoprotein).
English: Concomitant use may reduce the reflex sympathetic response involved when excessive distal vasodilatation.
Croatian: Istodobna primjena može smanjiti refleksnu simpatičku reakciju koja se javlja kod prekomjerne distalne vazodilatacije.
English: Beta-blockers will result in an attenuation of reflex tachycardia and an increased risk of hypotension.
Croatian: Beta-blokatori će dovesti do slabljenja refleksne tahikardije i povećanog rizika od hipotenzije.
English: This medicine is used to treat a disease called haemangioma.
Croatian: Ovaj lijek se koristi za liječenje bolesti nazvane hemangiom.
English: Prior to initiating propranolol therapy, screening for risks associated with propranolol use must be performed.
Croatian: Prije početka terapije s propranololom, mora se obaviti probir za rizike povezane s uporabom propranolola.
English: The recommended starting dose is 1 mg/kg/day which is divided into two separate doses of 0.5 mg/kg.
Croatian: Preporučena početna doza je 1 mg/kg/dan koja je podijeljena u dvije odvojene doze od 0,5 mg/kg.
English: The potential effects of propranolol on the development of juvenile rats were evaluated following daily oral administration from post-natal Day 4 (PND 4) to PND 21 at dose-levels of 0, 10, 20 or 40 mg/kg/day.
Croatian: Potencijalni učinci propranolola na razvoj mladih štakora procijenjeni su nakon dnevne peroralne primjene od post-natalnog 4. dana (PND 4) do PND 21 u razinama doze od 0, 10, 20 ili 40 mg/kg/dan.
English: The mixing should be used within 2 hours.
Croatian: Mješavina se mora potrošiti unutar 2 sata.
English: In this case, inform the caregiver, and increase monitoring of blood glucose levels, particularly at the start of treatment.
Croatian: U tom slučaju, obavijestite o tome pružatelja skrbi, te povećajte praćenje razine glukoze u krvi, osobito na početku liječenja.
English: Check the HEMANGIOL dose in milligrams (mg) as prescribed by your doctor.
Croatian: Provjerite koju je dozu u miligramima (mg) HEMANGIOL-a propisao liječnik.
English: The 4-hydroxy-propranolol metabolite was quantified, its plasma exposure accounting for less than 7% of the parent drug exposure.
Croatian: Metabolit 4-hidroksi-propranolola je bio kvantificiran, njegova izloženost u plazmi čini manje od 7% izloženosti matičnog lijeka.
English: Pharmacotherapeutic group: Beta-Blocking agent, non-selective, ATC code: C07AA05
Croatian: Farmakoterapijska skupina: beta-blokator, neselektivan, ATK oznaka: C07AA05 Mehanizam djelovanja
English: However, it undergoes an extensive first-pass metabolism by the liver and on average only about 25% of propranolol reaches the systemic circulation.
Croatian: Međutim, tijekom prvog prolaska kroz jetru opsežno se metabolizira i u prosjeku samo oko 25% propranolola dospije u sistemski krvotok.
English: Concommitant use not recommended
Croatian: Istodobna primjena se ne preporučuje