FrancophonIA/ELRC3.0 huggingface dataset:
English: In psoriasis, treatment with Otezla results in a reduction in psoriatic skin plaques and other signs and symptoms of the disease.
Danish: Ved psoriasis kan behandlingen med Otezla føre til en reduktion i psoriatiske hudpletter samt andre tegn og symptomer for sygdommen.
English: Patients previously treated with DMARDs or biologics who received apremilast achieved a greater ACR 20 response at week 16 than patients receiving placebo.
Danish: Patienter, der tidligere blev behandlet med DMARDs eller biologiske midler, og som fik apremilast, opnåede et større ACR 20respons efter uge 16 end patienterne, der fik placebo.
English: Very common side effects (may affect more than 1 in 10 people)
Danish: Meget almindelig bivirkninger (kan forekomme hos flere end 1 ud af 10 personer)
English: If you forget to take Otezla
Danish: Hvis du har glemt at tage Otezla
English: In both studies, patients were randomised 2:1 to apremilast 30 mg twice daily or placebo for 16 weeks (placebo-controlled phase) and from weeks 16-32, all patients received apremilast 30 mg twice daily (maintenance phase).
Danish: I begge studierne blev patienterne randomiseret i forholdet 2:1 til apremilast 30 mg 2 gange dagligt eller placebo i 16 uger (placebokontrolleret fase) og fra uge 16-32 fik alle patienter apremilast 30 mg to gange dagligt (vedligeholdelsesfase).
English: 10 mg (pink)
Danish: 10 mg (lyserød)
English: Co-administration of apremilast with multiple doses of rifampicin resulted in a decrease in apremilast area-under-the-concentration time curve (AUC) and maximum serum concentration (Cmax) by approximately 72% and 43%, respectively.
Danish: Administration af apremilast sammen med flere doser af rifampicin førte til en reduktion i arealet under kurven (AUC, koncentration vs. tid), og den maksimale serumkoncentration (Cmax) med hhv. ca. 72 % og 43 %.
English: In addition, apremilast demonstrated a treatment benefit across multiple manifestations of psoriasis including pruritus, nail disease, scalp involvement and quality of life measures.
Danish: Desuden viste apremilast en behandlingsfordel for flere manifestationer af psoriasis, herunder pruritus, neglesygdom, involvering af hårbunden og livskvalitetsmålinger.
English: PDE4 inhibition elevates intracellular cAMP levels, which in turn down-regulates the inflammatory response by modulating the expression of TNF-α, IL-23, IL-17 and other inflammatory cytokines.
Danish: PDE4-hæmning forhøjer intracellulære cAMP-niveauer, hvilket til gengæld nedregulerer det inflammatoriske respons ved at modulere ekspressionen af TNF-α, IL-23, IL-17 og andre inflammatoriske cytokiner.
English: • The active substance is apremilast.
Danish: • Aktivt stof: apremilast.
English: Percent Change in PASI from baseline, mean (%) ± SDa
Danish: Procent ændring i PASI fra baseline, gennemsnit (%) ± SDa
English: If you experience severe diarrhoea, nausea, or vomiting, you should talk to your doctor.
Danish: Hvis du oplever alvorlig diarré, kvalme eller opkastning, skal du kontakte lægen.
English: Patients received apremilast in combination with one or more of the following: methotrexate (MTX, ≤ 25 mg/week, 54.5%), sulfasalazine (SSZ, ≤ 2 g/day, 9.0%), and leflunomide (LEF; ≤ 20 mg/day, 7.4%).
Danish: Patienter fik apremilast i kombination med en eller flere af de følgende: methotrexat (MTX, ≤ 25 mg/ug, 54,5 %), sulfasalazin (SSZ, ≤ 2 g/dag, 9,0 %) og leflunomid (LEF, ≤ 20 mg/dag, 7,4 %).
English: Apremilast 30 mg twice daily
Danish: Apremilast 30 mg to gange dagligt
English: In the PsA or PSOR clinical studies, the safety profile observed in patients with mild renal impairment was comparable to patients with normal renal function.
Danish: I de kliniske studier af PsA eller PSOR var den observerede sikkerhedsprofil hos patienter med let nedsat nyrefunktion sammenlignelig med sikkerhedsprofilen hos patienter med normal nyrefunktion.
English: Physical signs of maternal toxicity associated with delivering pups were also observed in one mouse at each of 80 and 300 mg/kg/day.
Danish: Fysiske tegn på maternal toksicitet forbundet med at føde ungerne blev også observeret hos en mus ved både 80 og 300 mg/kg/dag.
English: Apremilast, an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4), works intracellularly to modulate a network of pro-inflammatory and anti-inflammatory mediators.
Danish: Apremilast, et lille molekyle, der tages oralt, hæmmer phosphodiesterase 4 (PDE4), virker intracellulært ved at modulere et netværk af proinflammatoriske og antiinflammatoriske mediatorer.
English: Otezla has also been shown to improve the quality of life in patients with psoriasis or psoriatic arthritis.
Danish: Otezla har også vist sig at forbedre livskvaliteten for patienter med psoriasis og psoriasis artritis.
English: In clinical studies, apremilast has been administered concomitantly with topical therapy (including corticosteroids, coal tar shampoo and salicylic acid scalp preparations) and UVB phototherapy.
Danish: I kliniske studier er apremilast blevet administreret sammen med topikal behandling (herunder kortikosteroider, tjæreshampoo og præparater til hårbunden med salicylsyre) samt UVB lysbehandling.
English: Of these patients, 12% achieved a PASI-75 response at week 52 with apremilast plus topical and/or phototherapy treatment.
Danish: Ud af disse patienter opnåede 12 % et PASI-75-respons efter uge 52 med apremilast plus topikal behandling og/eller lysbehandling.
English: There was no pharmacokinetic interaction between apremilast and methotrexate in psoriatic arthritis patients.
Danish: Der var ingen farmakokinetiske interaktioner mellem apremilast og methotrexat hos patienter med psoriasis artritis.
English: A total of 1,493 patients were randomised and treated with either placebo, apremilast 20 mg or apremilast 30 mg given orally twice daily.
Danish: I alt 1.493 patienter blev randomiseret og behandlet enten med placebo, apremilast 20 mg eller apremilast 30 mg administreret oralt, to gange dagligt.
English: Lactose content
Danish: Lactoseindhold
English: Apremilast was detected in milk of lactating mice (see section 5.3).
Danish: Apremilast blev detekteret i mælken hos diegivende mus (se pkt.
English: Response to apremilast was rapid, with significantly greater improvements in the signs and symptoms of psoriasis, including PASI, skin discomfort/pain and pruritus, compared to placebo by week 2.
Danish: Respons på apremilast var hurtigt, med signifikant større forbedringer i tegn og symptomer på psoriasis, herunder PASI, hudbesvær/smerter og pruritus, sammenlignet med placebo efter uge 2.
English: There was no pharmacokinetic interaction between apremilast and oral contraceptives containing ethinyl estradiol and norgestimate.
Danish: Der var ingen farmakokinetiske interaktioner mellem apremilast og oral kontraception, der indeholdt ethinyløstradiol og norgestimat.
English: • bleeding in the bowel or in the stomach
Danish: • blødning i tarmen eller maven
English: At weeks 16 and 24 improvements in parameters of peripheral activity characteristic of psoriatic arthritis (e.g. number of swollen joints, number of painful/tender joints, dactylitis and enthesitis) and in the skin manifestations of psoriasis were seen in the apremilast-treated patients.
Danish: Efter uge 16 og 24 blev der observeret forbedringer i parametre for perifer aktivitet karakteristisk for psoriasis artritis (f.eks. antallet af hævede led, antallet af smertefulde/ømme led, daktylitis og entesitis) og i hudmanifestationerne for psoriasis hos de apremilast-behandlede patienter.
English: Apremilast dose should be reduced to 30 mg once daily in patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2 or CLcr < 30 mL/min).
Danish: Apremilast-dosis skal reduceres til 30 mg én gang dagligt hos patienter med svært nedsat nyrefunktion (eGFR under 30 ml/min/1.73 m2 eller kreatininclearance < 30 ml/min).
English: NAME OF THE MARKETING AUTHORISATION HOLDER Celgene
Danish: NAVN PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN Celgene
English: The use of low potency topical corticosteroids on the face, axillae, and groin, coal tar shampoo and/or salicylic acid scalp preparations was permitted throughout the studies.
Danish: Anvendelsen af svage topikale kortikosteroider på ansigt, i armhuler og i lysken samt/eller salicylsyrepræparater til hårbunden var tilladt i løbet af alle studierne.
English: The safety of apremilast was not evaluated in PsA or PSOR patients with moderate or severe renal impairment in the clinical studies.
Danish: Sikkerheden af apremilast blev ikke evalueret hos patienter med PsA eller PSOR med moderat eller svært nedsat nyrefunktion i kliniske studier.
English: In vitro, apremilast is not an inhibitor or inducer of cytochrome P450 enzymes.
Danish: Apremilast er ikke en hæmmer eller inducer for cytokrom P450-enzymer in vitro.
English: INFORMATION IN BRAILLE Otezla 10 mg
Danish: INFORMATION I BRAILLESKRIFT Otezla 10 mg
English: The median time to loss of PASI-75 response among the patients re-randomised to placebo was 5.1 weeks.
Danish: Den mediane tid til tab af PASI-75-respons blandt patienterne, der igen blev randomiseret til placebo, var 5,1 uger.
English: If patients develop severe diarrhoea, nausea, or vomiting, discontinuation of treatment with apremilast may be necessary.
Danish: Hvis patienter udvikler svær diarré, kvalme eller opkastning, kan det være nødvendigt at seponere behandlingen med apremilast.
English: Patients and caregivers should be instructed to notify the prescriber of any changes in behaviour or mood and of any suicidal ideation.
Danish: Patienter og omsorgspersoner skal instrueres om at underrette den ordinerende læge om eventuelle ændringer i adfærd eller humør og om eventuelle selvmordstanker.
English: Among patients who remained on the apremilast treatment to which they were randomised at study start, DAS28(CRP) score and PsARC response were maintained through week 52.
Danish: Blandt patienter, der forblev på den apremilast-behandling de blev randomiseret til ved studiestart, blev DAS28(CRP)-score og PsARC-respons opretholdt til og med uge 52.
English: • The three-month standard pack contains 168 x 30 mg film-coated tablets.
Danish: • Standardpakningen for tre måneder indeholder 168 x 30 mg filmovertrukne tabletter.
English: The most commonly reported adverse reactions with apremilast are gastrointestinal (GI) disorders including diarrhoea (15.7%) and nausea (13.9%).
Danish: De mest almindeligt rapporterede bivirkninger med apremilast er mave-tarm-sygdomme, herunder diarré (15,7 %) og kvalme (13,9 %).
English: In addition, in Study ESTEEM 1, significant improvement in the Work Limitations Questionnaire (WLQ-25) Index was achieved in patients receiving apremilast compared to placebo.
Danish: Desuden blev der i studiet ESTEEM 1 opnået signifikante forbedringer i spørgeskemaet om arbejdsbegrænsninger (work limitations questionnaire, WLQ-25) Index hos patienter, der fik apremilast, sammenlignet med placebo.
English: Proportion of patients with ACR responses in studies PALACE 1, PALACE 2 and PALACE 3 and pooled studies at week 16
Danish: Andelen af patienter med ACR-respons i studie PALACE 1, PALACE 2 og PALACE 3 og samlede studier efter uge 16
English: Apremilast exposure is decreased when administered concomitantly with strong inducers of CYP3A4 (e.g. rifampicin) and may result in reduced clinical response.
Danish: Apremilast-eksponeringen er nedsat, når det administreres sammen med kraftige CYP3A4-inducere (f.eks. rifampicin), og kan føre til et reduceret klinisk respons.
English: Reductions in maternal body weight and weight gain, and one death associated with difficulty in delivering pups were observed at 300 mg/kg/day.
Danish: Reduktioner i maternal legemsvægt og vægtøgning, og et dødsfald forbundet med besvær med at føde ungerne blev observeret ved 300 mg/kg/dag.
English: MARKETING AUTHORISATION NUMBER(S) Otezla 10 mg, 20 mg, 30 mg film-coated tablets (initiation pack) EU/1/14/981/001
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) Otezla 10 mg, 20 mg, 30 mg filmovertrukne tabletter (pakning med den indledende behandling) EU/1/14/981/001
English: Otezla 10 mg, 20 mg, 30 mg film-coated tablets (initiation pack) PVC/ aluminium foil blisters containing 27 film-coated tablets (4 x10 mg, 4x 20 mg, 19 x 30 mg).
Danish: Otezla 10 mg, 20 mg, 30 mg filmovertrukne tabletter (pakning med den indledende behandling) Blistre af PVC/aluminiumsfolie indeholdende 27 filmovertrukne tabletter (4 x 10 mg, 4 x 20 mg, 19 x 30 mg).
English: Apremilast can be coadministered with a potent CYP3A4 inhibitor such as ketoconazole.
Danish: Apremilast kan administreres sammen med en kraftig CYP3A4-hæmmer som ketoconazol.
English: Film-coated tablet Treatment initiation pack
Danish: Filmovertrukket tablet Pakning med indledende behandling
English: After randomised withdrawal from therapy at week 32, approximately 70% of patients in Study ESTEEM 1, and 65.6% of patients in Study ESTEEM 2, regained PASI-75 (ESTEEM 1) or PASI-50 (ESTEEM 2) responses after re-initiation of apremilast treatment.
Danish: Efter randomiseret seponering af behandlingen efter uge 32 genetablerede ca. 70 % af patienter i studiet ESTEEM 1, og 65,6 % af patienterne i studiet ESTEEM 2 PASI-75 (ESTEEM 1)- eller PASI-50 (ESTEEM 2)-respons efter genindledning af apremilastbehandlingen.
English: Change in DLQI from baseline, mean± SDa
Danish: Ændring i DLQI fra baseline, gennemsnit± SDa
English: Change in SF-36 MCS h, mean± SD
Danish: (mm), gennemsnit± SD Ændring i DLQIg, gennemsnit± SD Ændring i SF-36 MCS h, gennemsnit± SD
English: INFORMATION IN BRAILLE Otezla 30 mg
Danish: INFORMATION I BRAILLESKRIFT Otezla 30 mg
English: Summary of adverse reactions in psoriatic arthritis (PsA) and/or psoriasis (PSOR)
Danish: Sammenfatning af bivirkninger i psoriasis artritis (PsA) og/eller psoriasis (PSOR) Systemorganklasse Hyppighed Bivirkning
English: All developmental effects were observed during the first week of the postnatal period; no apremilast-related effects were seen during the remaining pre- and post-weaning periods, including sexual maturation, behavioural, mating, fertility and uterine parameters.
Danish: Der blev ikke observeret nogen apremilastrelaterede virkninger i løbet af den resterende periode før og efter afvænning, herunder på kønsmodning, adfærd, parring, fertilitet og livmoderparametre.
English: Treatment with apremilast resulted in significant improvements in the signs and symptoms of PsA, as assessed by the ACR 20 response criteria compared to placebo at weeks 16.
Danish: Behandlingen med apremilast førte til signifikante forbedringer i tegn og symptomer på PsA ved vurdering efter responskriterierne fra ACR 20, sammenlignet med placebo efter uge 16.
English: Among patients who remained on the apremilast treatment to which they were randomised at study start, these improvements were maintained through week 52.
Danish: Blandt patienter, der forblev på den apremilast-behandling de blev randomiseret til ved studiestart, blev disse forbedringer opretholdt til og med uge 52.
English: In a pre- and postnatal study, apremilast was administered orally to pregnant female mice at dosages of 10, 80 and 300 mg/kg/day from gestation day (GD) 6 to Day 20 of lactation.
Danish: I et præ- og postnatalt studie blev apremilast administreret oralt til drægtige hunmus ved doseringer på 10, 80 og 300 mg/kg/dag fra gestationsdag (GD) 6 til dag 20 af diegivningen.
English: Increased numbers of early resorptions and reduced numbers of ossified tarsals were observed at 20, 40, and 80 mg/kg/day.
Danish: Et øget antal tidlige resorptioner og et nedsat antal ossificerede fodrodsknogler blev observeret ved 20, 40 og 80 mg/kg/dag.
English: At week 24, all remaining placebo-treated patients were switched to either apremilast 20 or 30 mg twice daily.
Danish: Efter uge 24 blev alle resterende patienter i placebobehandling skiftet til enten apremilast 20 eller 30 mg to gange dagligt.
English: Consistent with apremilast being a substrate of CYP3A4, apremilast exposure is decreased when administered concomitantly with rifampicin, a strong inducer of CYP3A4.
Danish: I overensstemmelse med, at apremilast er et substrat for CYP3A4, er eksponeringen af apremilast nedsat, når det administreres samtidigt med rifampicin, en kraftig CYP3A4-inducer.
English: • The one-month standard pack contains 56 x 30 mg film-coated tablets.
Danish: • Standardpakningen for en måned indeholder 56 x 30 mg filmovertrukne tabletter.
English: During the Randomised Treatment Withdrawal Phase (weeks 32-52), patients originally randomised to apremilast who achieved at least a 75% reduction in their PASI score (PASI-75) (ESTEEM 1) or a 50% reduction in their PASI score (PASI-50) (ESTEEM 2) were re-randomised at week 32 to either placebo or apremilast 30 mg twice daily.
Danish: I løbet af den randomiserede behandlingsafbrydelsesfase (uge 32-52) blev patienter, der oprindeligt blev randomiseret til apremilast, som opnåede en mindst 75 % reduktion i deres PASI-score (PASI-75) (ESTEEM 1) eller en 50 % reduktion i deres PASI-score (PASI-50) (ESTEEM 2) igen randomiseret efter uge 32 til enten placebo eller apremilast 30 mg to gange dagligt.
English: Treatment with apremilast resulted in significant improvement in moderate to severe plaque psoriasis as demonstrated by the proportion of patients with PASI-75 response at week 16, compared to placebo.
Danish: Behandling med apremilast førte til signifikante forbedringer i moderat til svær plaque psoriasis, vist ved andelen af patienter med PASI-75-respons efter uge 16, sammenlignet med placebo.
English: The dose of apremilast should be reduced to 30 mg once daily in patients with severe renal impairment (creatinine clearance of less than 30 mL per minute estimated by the Cockcroft-Gault equation).
Danish: Dosis af apremilast bør reduceres til 30 mg én gang dagligt hos patienter med svært nedsat nyrefunktion (kreatininclearance under 30 ml pr. minut, estimeret via Cockcroft-Gault-ligningen).
English: • St John's Wort - a herbal medicine for mild anxiety and depression.
Danish: • prikbladet perikon - et naturlægemiddel mod let angst og depression.
English: Body weight loss
Danish: Tab af legemsvægt
English: Otezla has not been studied in children and adolescents, therefore it is not recommended for use in children and adolescents aged 17 years and under.
Danish: Derfor bør det ikke anvendes til børn og unge i alderen 17 år og derunder.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Otezla 10 mg film-coated tablets
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING Otezla 10 mg filmovertrukne tabletter
English: Patients and caregivers should be instructed to notify the prescriber of any suicidal ideation (see section 4.4).
Danish: Patienter og omsorgspersoner skal instrueres om at underrette den ordinerende læge om eventuelle selvmordstanker (se pkt.
English: The safety and efficacy of apremilast were evaluated in 3 multi-centre, randomised, double-blind, placebocontrolled studies (Studies PALACE 1, PALACE 2, and PALACE 3) of similar design in adult patients with active PsA (≥ 3 swollen joints and ≥ 3 tender joints) despite prior treatment with small molecule or biologic DMARDs.
Danish: Apremilasts sikkerhed og virkning blev evalueret i 3 randomiserede, dobbeltblindede, placebokontrollerede multicenterstudier (studie PALACE 1, PALACE 2 og PALACE 3) med sammenligneligt design hos voksne patienter med aktiv PsA (≥ 3 hævede led og ≥ 3 ømme led), trods tidligere behandling med et lille molekyle eller biologiske DMARDs.
English: Patients who did not achieve the designated PASI response by week 32, or who were initially randomised to placebo, remained on apremilast until week 52.
Danish: Patienterne, som ikke opnåede det tildelte PASIrespons efter uge 32, eller som indledningsvist blev randomiseret til placebo, blev i behandling med apremilast indtil uge 52.
English: 20 mg (brown)
Danish: 20 mg (brun)
English: The results support that no dose adjustment is needed in patients with mild and moderate renal impairment.
Danish: Resultaterne støtter, at dosisjustering ikke er nødvendig hos patienter med let til moderat nedsat nyrefunktion.
English: The proportion of patients with ACR 20/50/70 (responses in studies PALACE 1, PALACE 2 and PALACE 3, and the pooled data for studies PALACE 1, PALACE 2 and PALACE 3) for apremilast 30 mg twice daily at week 16 are shown in Table 3.
Danish: Andelen af patienter med ACR 20/50/70 (respons i studie PALACE 1, PALACE 2 og PALACE 3, og de samlede data fra studie PALACE 1, PALACE 2 og PALACE 3) for apremilast 30 mg to gange dagligt efter uge 16 vises i tabel 3.
English: Do not take Otezla:
Danish: Tag ikke Otezla:
English: Patients who were re-randomised to placebo and who lost PASI-75 response (ESTEEM 1) or lost 50% of the PASI improvement at week 32 compared to baseline (ESTEEM 2) were retreated with apremilast 30 mg twice daily.
Danish: Patienter, som igen blev randomiseret til placebo, og som mistede PASI-75-responset (ESTEEM 1) eller mistede 50 % af PASI-forbedringen efter uge 32 sammenlignet med baseline (ESTEEM 2), blev genbehandlet med apremilast 30 mg to gange dagligt.
English: Increased peri- and postnatal pup deaths and reduced pup body weights during the first week of lactation were observed at ≥ 80 mg/kg/day (≥ 4.0-fold clinical exposure).
Danish: En øget forekomst af peri- og postnatalt dødsfald af ungerne og nedsat legemsvægt af ungerne i løbet af den først diegivningsuge blev observeret ved ≥ 80 mg/kg/dag (≥ 4,0 gange klinisk eksponering).
English: The improvements were generally maintained in subjects who were re-randomised to apremilast at week 32 through week 52 (Table 5).
Danish: Forbedringerne blev generelt opretholdt hos personer, der igen blev randomiseret til apremilast fra uge 32 til og med uge 52 (tabel 5).
English: Driving and using machines Otezla has no effect on the ability to drive and use machines.
Danish: Trafik- og arbejdssikkerhed Otezla påvirker ikke evnen til at føre motorkøretøj og betjene maskiner.
English: Placebo patients who were considered non-responders were rerandomised 1:1 in a blinded fashion to either apremilast 20 mg twice daily or 30 mg twice daily.
Danish: Placebopatienterne, som blev anset for ikke at respondere, blev randomiseret igen i forholdet 1:1 med blinding til enten apremilast 20 mg to gange dagligt eller 30 mg to gange dagligt.
English: Among patients who were initially randomised to apremilast 30 mg twice daily treatment, the change from baseline in the HAQ-DI score at week 52 was -0.333 in the apremilast 30 mg twice daily group in a pooled analysis of the open label phase of studies PALACE 1, PALACE 2 and PALACE 3.
Danish: Blandt de patienter, der indledningsvist blev randomiseret til behandling med apremilast 30 mg to gange dagligt, var ændringen fra baseline i HAQ-DI-score efter uge 52 -0,333 i gruppen med apremilast 30 mg i de samlede analyser af open label-faserne i studierne PALACE 1, PALACE 2 og PALACE 3.
English: Apremilast is contraindicated during pregnancy (see section 4.3).
Danish: Apremilast bør ikke anvendes under graviditeten (se pkt.
English: • hives (urticaria)
Danish: • nældefeber (urticaria)
English: Apremilast-treated patients demonstrated statistically significant improvement in physical function, as assessed by the disability index of the health assessment questionnaire (HAQ-DI) change from baseline, compared to placebo at weeks 16 in PALACE 1, PALACE 2 and PALACE 3 and in the pooled studies Improvement in HAQ-DI scores was maintained at week 24.
Danish: Apremilast-behandlede patienter viste statistisk signifikant forbedring i fysisk funktion, vurderet ved handicapindekset for spørgeskemaet til vurdering af helbredet (health assessment questionnaire, HAQDI) ændring fra baseline, sammenlignet med placebo efter uge 16 i PALACE 1, PALACE 2 og PALACE 3 og i de samlede studier.
English: DMARDs N=497
Danish: N = 497
English: Psoriatic arthritis
Danish: Psoriasis artritis
English: Among 497 patients initially randomised to apremilast 30 mg twice daily, 375 (75%) patients were still on this treatment on week 52.
Danish: Blandt 497 patienter, der indledningsvist blev randomiseret til apremilast 30 mg to gange dagligt, var 375 (75 %) af patienterne stadig i denne behandling efter uge 52.