FrancophonIA/ELRC3.0 huggingface dataset:
English: • patients being treated for heart attack with ST-segment elevation, when the doctor thinks that they would benefit from treatment to dissolve blood clots.
Danish: • patienter, der er i behandling for hjerteanfald med ST-segmentøgning, når lægen mener, at de kan have fordel af behandling, der opløser blodpropper.
English: It also presented the results of 3 previous studies involving over 61,000 patients with unstable angina or who had had a heart attack.
Danish: Virksomheden fremlagde desuden resultater af tre tidligere undersøgelser med i alt over 61 000 patienter, der havde ustabil angina eller havde haft et hjerteanfald.
English: Acetylsalicylic acid has been available for over 100 years.
Danish: Acetylsalicylsyre har kunnet fås i over 100 år.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Clopidogrel/Acetylsalicylic acid Zentiva.
Danish: Det forklarer, hvordan Udvalget for Lægemidler til Mennesker (CHMP) vurderede lægemidlet og nåede frem til sin udtalelse til fordel for udstedelse af en markedsføringstilladelse og til sine anbefalinger om, hvordan Clopidogrel/Acetylsalicylsyre Zentiva skal anvendes.
English: Clopidogrel/Acetylsalicylic acid Zentiva must not be used during the last three months of pregnancy.
Danish: Clopidogrel/Acetylsalicylsyre Zentiva må ikke tages i de sidste tre måneder af graviditeten.
English: Clopidogrel has been authorised since 1998 for reducing platelet aggregation, and is often used in combination with acetylsalicylic acid.
Danish: Clopidogrel har været godkendt siden 1998 til nedsættelse af blodpladers sammenklæbning og anvendes ofte sammen med acetylsalicylsyre.
English: The name of the medicine was changed to Clopidogrel/Acetylsalicylic acid Zentiva on 15 January 2016.
Danish: Lægemidlets navn blev ændret til Clopidogrel/Acetylsalicylsyre Zentiva den 15. januar 2016.
English: The Committee therefore decided that Clopidogrel/Acetylsalicylic acid Zentiva's benefits are greater than its risks and recommended that it be given marketing authorisation.
Danish: Udvalget besluttede derfor, at fordelene ved Clopidogrel/Acetylsalicylsyre Zentiva opvejer risiciene, og anbefalede udstedelse af markedsføringstilladelse.
English: This document is a summary of the European Public Assessment Report (EPAR) for Clopidogrel/Acetylsalicylic acid Zentiva.
Danish: Dette dokument er et sammendrag af den europæiske offentlige vurderingsrapport (EPAR) for Clopidogrel/Acetylsalicylsyre Zentiva.
English: For more information about treatment with Clopidogrel/Acetylsalicylic acid Zentiva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Danish: Hvis du ønsker yderligere oplysninger om behandling med Clopidogrel/Acetylsalicylsyre Zentiva, kan du læse indlægssedlen (også en del af denne EPAR) eller kontakte din læge eller dit apotek.
English: The European Commission granted a marketing authorisation valid throughout the EU for DuoCover on 15 March 2010.
Danish: Europa-Kommissionen udstedte en markedsføringstilladelse med gyldighed i hele Den Europæiske Union for Clopidogrel/Acetylsalicylsyre Zentiva den 15. marts 2010.
English: The combination of the two active substances has an additive effect, reducing the risk of blood clots forming more than either medicine alone.
Danish: Virkningen af de to aktive stoffer supplerer hinanden, dvs. risikoen for blodpropper nedsættes mere end med hvert lægemiddel for sig.
English: It must not be used in patients who have a disease that is causing bleeding, such as stomach ulcer or bleeding in the brain, or in patients with mastocytosis (high blood levels of certain white blood cells called mast cells).
Danish: Det må ikke anvendes hos patienter, som har en blødningssygdom som f.eks. mavesår eller blødning i hjernen, eller hos patienter med mastocytose (højt indhold i blodet af særlige hvide blodlegemer, der kaldes mastceller).
English: The most common side effects with Clopidogrel/Acetylsalicylic acid Zentiva (seen in between 1 and 10 patients in 100) are haematoma (a collection of blood under the skin), epistaxis (nosebleeds), gastrointestinal haemorrhage (bleeding in the stomach or gut), diarrhoea, abdominal pain (stomach ache), dyspepsia (heartburn), bruising, and bleeding where the skin is punctured.
Danish: De hyppigste bivirkninger ved Clopidogrel/Acetylsalicylsyre Zentiva (der optræder hos mellem 1 og 10 patienter ud af 100) er blodsamling under huden (hæmatom), næseblod (epistaksis), gastrointestinale blødninger (blødninger i mave eller tarm), diarré, mavesmerter, dyspepsi (halsbrand), blå mærker og blødning på punkturstedet.
English: This stops the platelets becoming ‘sticky', reducing the risk of a blood clot forming.
Danish: Dette forhindrer blodpladerne i at blive "klæbrige" og nedsætter dermed risikoen for blodpropper.
English: This reduces the production of a substance called thromboxane, which normally helps clots to form by attaching platelets together.
Danish: Det reducerer produktionen af et stof, der kaldes tromboxan, som normalt er med til at få blodet til at klumpe sammen ved at få blodpladerne til at klæbe sammen.
English: • patients who have unstable angina (a severe type of chest pain) or who have had a heart attack with no ‘ST-segment elevation' (an abnormal reading on the ECG or electrocardiogram), including those who are having a stent (a short tube) inserted into an artery to prevent it from closing up;
Danish: • patienter, der har svære, ustabile brystsmerter (angina) eller har haft et hjerteanfald uden den unormale forandring i elektrokardiogrammet (»ST-segmentøgning«), herunder patienter, der har fået indsat en kort slange (en stent) i en arterie for at undgå, at den blokeres
English: It must not be used in patients who have severely reduced liver or kidney function, or who have a medical condition that includes a combination of asthma, rhinitis (stuffy and runny nose) and nasal polyps (growths in the lining of the nose).
Danish: Det må ikke anvendes hos patienter, som har alvorligt nedsat lever- eller nyrefunktion, eller som har en sygdom, der omfatter en kombination af astma, rhinitis (tilstoppet og løbende næse) og næsepolypper (gevækster i næsens slimhinde).
English: This means that they help to prevent blood cells called platelets from sticking together and forming clots, thus helping to prevent another heart attack.
Danish: Det betyder, at de forhindrer blodpladerne i at klæbe til hinanden og danne blodpropper og dermed forebygger nye hjerteanfald.
English: Clopidogrel/Acetylsalicylic acid Zentiva is a medicine that contains two active substances, clopidogrel and acetylsalicylic acid (also known as aspirin).
Danish: Clopidogrel/Acetylsalicylsyre Zentiva er et lægemiddel, som indeholder to aktive stoffer, clopidogrel og acetylsalicylsyre (også kendt som aspirin).
English: Acetylsalicylic acid stops the platelets sticking together by blocking an enzyme called prostaglandin cyclo-oxygenase.
Danish: Acetylsalicylsyre forhindrer blodpladerne i at klæbe til hinanden ved at blokere enzymet prostaglandin cyclooxygenase.
English: Clopidogrel/Acetylsalicylic acid Zentiva must not be used in people who are hypersensitive (allergic) to clopidogrel, non steroidal anti-inflammatory drugs (such as acetylsalicylic acid) or any of the other ingredients in Clopidogrel/Acetylsalicylic acid Zentiva.
Danish: Clopidogrel/Acetylsalicylsyre Zentiva må ikke anvendes hos patienter, der er overfølsomme (allergiske) over for clopidogrel, non-steroide antiinflammatoriske stoffer (såsom acetylsalicylsyre) eller andre af indholdsstofferne i Clopidogrel/Acetylsalicylsyre Zentiva.
English: Clopidogrel stops the platelets sticking together by blocking a substance called ADP from attaching to a special receptor on their surface.
Danish: Clopidogrel forhindrer blodpladerne i at klæbe til hinanden ved at forhindre stoffet ADP i at binde sig til en særlig receptor på blodpladernes overflade.
English: Both active substances in Clopidogrel/Acetylsalicylic acid Zentiva, clopidogrel and acetylsalicylic acid, are antiplatelet medicines.
Danish: Begge aktive stoffer i Clopidogrel/Acetylsalicylsyre Zentiva, clopidogrel og acetylsalicylsyre, er antitrombocytlægemidler.
English: The CHMP noted that Clopidogrel/Acetylsalicylic acid Zentiva is comparable to clopidogrel and acetylsalicylic acid tablets taken separately, and concluded that combining both active substances in a single Clopidogrel/Acetylsalicylic acid Zentiva tablet simplifies treatment for patients as they will need to take fewer tablets.
Danish: CHMP bemærkede, at Clopidogrel/Acetylsalicylsyre Zentiva svarer til clopidogrel- og acetylsalicylsyretabletter, der tages separat, og udvalget konkluderede, at en kombination af begge aktive stoffer i én Clopidogrel/Acetylsalicylsyre Zentiva-tablet gør behandlingen enklere for patienterne, eftersom de skal tage færre tabletter.
English: Clopidogrel/Acetylsalicylic acid Zentiva was shown to be comparable to clopidogrel and acetylsalicylic acid taken separately, and can therefore be used in place of the clopidogrel and acetylsalicylic acid tablets that the patients have already been taking.
Danish: Det blev påvist, at Clopidogrel/Acetylsalicylsyre Zentiva kan sammenlignes med clopidogrel og acetylsalicylsyre taget separat, og det kan derfor anvendes i stedet for de clopidogrel- og acetylsalicylsyretabletter, som patienterne tidligere har taget.
English: For the full list of all side effects reported with Clopidogrel/Acetylsalicylic acid Zentiva, see the package leaflet.
Danish: Den fuldstændige liste over indberettede bivirkninger ved Clopidogrel/Acetylsalicylsyre Zentiva fremgår af indlægssedlen.
English: Clopidogrel/Acetylsalicylic acid Zentiva is taken as one tablet once a day in place of the clopidogrel and acetylsalicylic acid tablets that the patient has already been taking separately.
Danish: Der skal tages én Clopidogrel/Acetylsalicylsyre Zentiva-tablet om dagen i stedet for de clopidogrel- og acetylsalicylsyretabletter, som patienten tidligere har taget separat.
English: Because the two active substances have been used together for a number of years, the company presented the results of studies showing that the active substances in Clopidogrel/Acetylsalicylic acid Zentiva are absorbed in the body in the same way when taken in a single tablet as when the two medicines are taken separately.
Danish: Virksomheden fremlagde derfor undersøgelser, der viser, at de aktive stoffer i Clopidogrel/Acetylsalicylsyre Zentiva optages på samme måde i kroppen, når de tages som en enkelt tablet, som når de to lægemidler tages hvert for sig.
English: Results from the 3 studies in patients with unstable angina or who had had a heart attack showed that the combination of clopidogrel and acetylsalicylic acid taken as separate tablets was more effective at preventing events such as heart attacks than acetylsalicylic acid alone.
Danish: Undersøgelserne viste, at kombinationen clopidogrel og acetylsalicylsyre, taget som separate tabletter, var bedre til at forebygge tilfælde som hjerteanfald end acetylsalicylsyre alene.
English: Clopidogrel/Acetylsalicylic acid Zentiva is used to prevent problems caused by blood clots, such as a heart attack, in adults who are already taking both clopidogrel and acetylsalicylic acid as separate tablets.
Danish: Det anvendes til at forebygge problemer forårsaget af blodpropper, såsom hjerteanfald, hos voksne, der i forvejen får både clopidogrel og acetylsalicylsyre (aspirin) som separate tabletter.
English: What is the risk associated with Clopidogrel/Acetylsalicylic acid Zentiva?
Danish: Hvilken risiko er der forbundet med Clopidogrel/Acetylsalicylsyre Zentiva?
English: Other information about Clopidogrel/Acetylsalicylic acid Zentiva:
Danish: Andre oplysninger om Clopidogrel/Acetylsalicylsyre Zentiva
English: Why has Clopidogrel/Acetylsalicylic acid Zentiva been approved?
Danish: Hvorfor blev Clopidogrel/Acetylsalicylsyre Zentiva godkendt?
English: Clopidogrel/Acetylsalicylic acid Zentiva clopidogrel / acetylsalicylic acid
Danish: Clopidogrel/Acetylsalicylsyre Zentiva1
English: How has Clopidogrel/Acetylsalicylic acid Zentiva been studied?
Danish: Hvordan blev Clopidogrel/Acetylsalicylsyre Zentiva undersøgt?
English: What is Clopidogrel/Acetylsalicylic acid Zentiva?
Danish: Hvad er Clopidogrel/Acetylsalicylsyre Zentiva?
English: How is Clopidogrel/Acetylsalicylic acid Zentiva used?
Danish: Hvordan anvendes Clopidogrel/Acetylsalicylsyre Zentiva?
English: What is Clopidogrel/Acetylsalicylic acid Zentiva used for?
Danish: Hvad anvendes Clopidogrel/Acetylsalicylsyre Zentiva til?
English: How does Clopidogrel/Acetylsalicylic acid Zentiva work?
Danish: Hvordan virker Clopidogrel/Acetylsalicylsyre Zentiva?
English: What benefit has Clopidogrel/Acetylsalicylic acid Zentiva shown during the studies?
Danish: Hvilken fordel viser undersøgelserne, at der er ved Clopidogrel/Acetylsalicylsyre Zentiva?
English: This authorisation was based on the authorisation granted to Plavix in 1998 (‘informed consent').
Danish: Denne tilladelse byggede på den tilladelse, som blev udstedt for Plavix i 1998 (‘informeret samtykke').
English: The European Commission granted a marketing authorisation valid throughout the European Union for Clopidogrel Winthrop on 16 July 2008.
Danish: Europa-Kommissionen udstedte en markedsføringstilladelse med gyldighed i hele Den Europæiske Union for Clopidogrel Winthrop den 16. juli 2008.
English: The full EPAR for Clopidogrel Zentiva can be found on the Agency's: website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Danish: Den fuldstændige EPAR for Clopidogrel Zentiva findes på agenturets websted under: website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: The name of the medicine was changed to Clopidogrel Zentiva on 23 August 2011.
Danish: Lægemidlets navn blev ændret til Clopidogrel Zentiva den 23. august 2011.
English: This is a summary of the European public assessment report (EPAR) for Clopidogrel Zentiva.
Danish: Dette dokument er et sammendrag af den europæiske offentlige vurderingsrapport (EPAR) for Clopidogrel Zentiva.
English: This showed that Clopidogrel Zentiva reduces the risk of an event.
Danish: Dette viser, at Clopidogrel Zentiva mindsker risikoen for en hændelse.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Clopidogrel Zentiva.
Danish: Det forklarer, hvordan Udvalget for Lægemidler til Mennesker (CHMP) vurderede lægemidlet og nåede frem til sin udtalelse til fordel for udstedelse af en markedsføringstilladelse og til sine anbefalinger om anvendelsesbetingelserne for Clopidogrel Zentiva.
English: Some of these patients have had a stent inserted (a short tube) placed in an artery to prevent it from closing up.
Danish: Nogle af disse patienter har fået indsat en stent (et kort rør) i en arterie for at forhindre denne i at indsnævre sig.
English: For more information about treatment with Clopidogrel Zentiva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Danish: Hvis du ønsker yderligere oplysninger om behandling med Clopidogrel Zentiva, kan du læse indlægssedlen (også en del af denne EPAR) eller kontakte din læge eller dit apotek.
English: In CAPRIE, there were 939 events in the Clopidogrel Zentiva group, and 1,020 in the aspirin group.
Danish: I CAPRIE-undersøgelsen var der 939 hændelser i Clopidogrel Zentiva-gruppen og 1 020 i aspiringruppen.
English: Clopidogrel Zentiva was more effective than aspirin at preventing new ischaemic events.
Danish: Clopidogrel Zentiva var mere effektivt end aspirin til forebyggelse af nye iskæmiske hændelser.
English: This means that fewer patients will have new ischaemic events if they receive Clopidogrel Zentiva than if they receive aspirin.
Danish: Dette betyder, at færre patienter vil opleve nye iskæmiske hændelser, når de får Clopidogrel Zentiva, end hvis de får aspirin.
English: The CHMP decided that Clopidogrel Zentiva's benefits are greater than its risks and recommended that it be given marketing authorisation.
Danish: CHMP besluttede, at fordelene ved Clopidogrel Zentiva opvejer risiciene, og anbefalede udstedelse af markedsføringstilladelse.
English: In other words, about 10 patients in 1,000 will avoid having a new ischaemic event two years after starting Clopidogrel Zentiva instead of aspirin.
Danish: Det vil sige, at ca. 10 patienter af 1 000 vil undgå en ny iskæmisk hændelse to år efter at de er begyndt at tage Clopidogrel Zentiva i stedet for aspirin.
English: Clopidogrel Zentiva is converted into its active form in the body.
Danish: Clopidogrel Zentiva omdannes til sin aktive form i kroppen.
English: For genetic reasons, some patients may not be able to convert Clopidogrel Zentiva as effectively as others, which could reduce their response to the medicine.
Danish: Visse patienter er af genetiske årsager måske ikke i stand til at omdanne Clopidogrel Zentiva lige så effektivt som andre og reagerer måske ikke lige så godt på lægemidlet.
English: Clopidogrel Zentiva is used to prevent problems caused by blood clots in adults who have:
Danish: Clopidogrel Zentiva anvendes til forebyggelse af problemer forårsaget af blodpropper hos voksne, som
English: The standard dose of Clopidogrel Zentiva is one 75-mg tablet once a day.
Danish: Standarddosis af Clopidogrel Zentiva er en tablet a 75 mg en gang dagligt.
English: This stops the platelets becoming ‘sticky', reducing the risk of a blood clot forming and helping to prevent another heart attack or stroke.
Danish: Dette forhindrer dem i at blive ‘klæbrige' og mindsker således risikoen for, at der dannes blodpropper, og medvirker til at forebygge endnu et hjerte- eller et slagtilfælde.
English: Clopidogrel Zentiva should not be used in people who may be hypersensitive (allergic) to clopidogrel or any of the other ingredients.
Danish: Clopidogrel Zentiva bør ikke anvendes til patienter, som kan være overfølsomme (allergiske) over for Clopidogrel eller andre af indholdsstofferne.
English: Acute coronary syndrome is a group of heart problems that include heart attacks and unstable angina (a severe type of chest pain).
Danish: Akut koronart syndrom er en samlebetegnelse for hjerteproblemer, som omfatter hjerteanfald og ustabil angina (en svær form for brystsmerter).
English: Clopidogrel Zentiva can be started between a few days and 35 days after the attack;
Danish: Behandling med Clopidogrel Zentiva kan indledes få dage efter anfaldet og indtil 35 dage efter
English: The most common side effects with Clopidogrel Zentiva (seen in between 1 and 10 patients in 100) are haematoma (a collection of blood under the skin), epistaxis (nosebleeds), gastrointestinal haemorrhage (bleeding in the stomach or gut), diarrhoea, abdominal pain (stomach ache), dyspepsia (heartburn), bruising and bleeding where the skin is punctured.
Danish: De hyppigste bivirkninger ved Clopidogrel Zentiva (der optræder hos mellem 1 og 10 patienter af 100) er hæmatom (blodsamling under huden), epistaksis (næseblod), gastrointestinale blødninger (blødninger i mave eller tarm), diarré, mavesmerter, dyspepsi (halsbrand), blå mærker og blødning på punkturstedet.
English: Other information about Clopidogrel Zentiva
Danish: Andre oplysninger om Clopidogrel Zentiva
English: Clopidogrel Zentiva is a medicine that contains the active substance clopidogrel.
Danish: Clopidogrel Zentiva er et lægemiddel, der indeholder det aktive stof clopidogrel.
English: For the full list of all side effects reported with Clopidogrel Zentiva, see the Package Leaflet.
Danish: Den fuldstændige liste over alle de indberettede bivirkninger ved Clopidogrel Zentiva fremgår af indlægssedlen.
English: Clopidogrel Zentiva can be started between seven days and six months after the stroke;
Danish: Behandling med Clopidogrel Zentiva kan indledes syv dage efter slagtilfældet og indtil seks måneder efter
English: In ST segment elevation myocardial infarction, fewer patients on Clopidogrel Zentiva had events than patients on placebo (262 against 377 in the CLARITY study, and 2,121 against 2,310 in the COMMIT study).
Danish: Ved myokardieinfarkt med forhøjelse af ST-segmentet havde færre af de Clopidogrel Zentiva-behandlede patienter hændelser end de placebo-behandlede patienter (262 i forhold til 377 i CLARITY-undersøgelsen og 2 121 i forhold til 2 310 i COMMIT-undersøgelsen).
English: Clopidogrel Zentiva has also been compared with placebo in two studies involving patients with ST segment elevation: CLARITY, which involved over 3,000 patients and lasted for up to eight days; and COMMIT, which involved almost 46,000 patients and in which the patients received Clopidogrel Zentiva with or without metoprolol (another medicine used for heart problems or high blood pressure) for up to four weeks.
Danish: Clopidogrel Zentiva blev også sammenlignet med placebo i to undersøgelser, der omfattede patienter med forhøjelse af ST-segmentet: CLARITY, som omfattede over 3 000 patienter, og som varede i op til otte dage, og COMMIT, som omfattede næsten 46 000 patienter, og i løbet af hvilken patienterne fik Clopidogrel Zentiva med eller uden metoprolol (et andet lægemiddel anvendt ved hjerteproblemer eller forhøjet blodtryk) i op til fire uger.
English: In the study in atrial fibrillation patients, Clopidogrel Zentiva taken together with aspirin reduced the risk of new events by 11% compared with placebo taken with aspirin, with the largest reduction (28%) seen for stroke.
Danish: I undersøgelsen af atrieflimren nedsatte Clopidogrel Zentiva taget sammen med aspirin risikoen for nye hændelser med 11 % sammenlignet med placebo taget sammen med aspirin, idet slagtilfælde tegnede sig for den største nedsættelse (28 %).
English: Clopidogrel Zentiva has been compared with aspirin in a study called CAPRIE including around 19,000 patients who had recently had a heart attack or ischaemic stroke, or who had established peripheral arterial disease.
Danish: Clopidogrel Zentiva blev sammenlignet med aspirin i en undersøgelse kaldet CAPRIE, hvori der indgik ca. 19 000 patienter, som inden for den seneste tid havde haft et hjerteanfald eller et iskæmisk slagtilfælde, eller som havde påvist perifer arteriesygdom.
English: In atrial fibrillation, Clopidogrel Zentiva has been compared with placebo (both taken together with aspirin) in one main study involving around 7,500 patients who had at least one risk factor for vascular events and who could not take vitamin K antagonist therapy.
Danish: Clopidogrel Zentiva blev til atrieflimren sammenlignet med placebo (begge taget sammen med aspirin) i en hovedundersøgelse, som omfattede ca. 7 500 patienter, der havde mindst en risikofaktor for vaskulære hændelser, og som ikke kunne tåle vitamin K-antagonistterapi.
English: In acute coronary syndrome, Clopidogrel Zentiva has been compared with placebo (a dummy treatment) in one study involving over 12,000 patients with non-ST segment elevation, 2,172 of whom had a stent inserted during the study (CURE study, lasting up to a year).
Danish: Ved akut koronart syndrom blev Clopidogrel Zentiva sammenlignet med placebo (en virkningsløs behandling) i en undersøgelse, som omfattede godt 12 000 patienter med non-ST-segment elevation, hvoraf 2 172 fik en stent indsat i løbet af undersøgelsen (CURE-undersøgelsen varede i op til et år).
English: Previously known as Clopidogrel Winthrop events such as a heart attack or stroke, cannot take vitamin K antagonists (other medicines that prevent blood clots) and are at low risk of bleeding.
Danish: Det anvendes til patienter, som har mindst en risikofaktor for Tidligere kendt som Clopidogrel Winthrop vaskulære hændelser såsom hjerteanfald eller slagtilfælde, som ikke kan tage vitamin Kantagonister (andre lægemidler, der forebygger blodpropper), og som har en lille blødningsrisiko.
English: The active substance in Clopidogrel Zentiva, clopidogrel, is an inhibitor of platelet aggregation.
Danish: Det aktive stof i Clopidogrel Zentiva , clopidogrel, er en trombocytfunktionshæmmer.