FrancophonIA/ELRC3.0 huggingface dataset:
English: DO NOT MIX OR CO-INFUSE CASPOFUNGIN ACCORD WITH ANY OTHER MEDICINES, as there are no data available on the compatibility of Caspofungin Accord with other intravenous substances, additives, or medicinal products.
Croatian: NEMOJTE MIJEŠATI NI DAVATI Caspofungin Accord U INFUZIJI ISTODOBNO S DRUGIM LIJEKOVIMA jer nema podataka o kompatibilnosti lijeka Caspofungin Accord s ostalim intravenskim pripravcima, aditivima ili lijekovima.
English: • rash, itching, feeling warm, swelling of your face, lips or throat or difficulty breathing - you may be having a histamine reaction to the medicine.
Croatian: • osip, svrbež, osjećaj topline, oticanje lica, usana ili grla uz otežano disanje - možda imate histaminsku reakciju na lijek.
English: What Caspofungin Accord is and what it is used for What you need to know before you are given Caspofungin Accord How to use Caspofungin Accord
Croatian: Što je Caspofungin Accord i za što se koristi Što morate znati prije nego počnete primati Caspofungin Accord Kako primjenjivati Caspofungin Accord Moguće nuspojave
English: • Treatment of invasive candidiasis in adult or paediatric patients.
Croatian: • Liječenje invazivne kandidijaze u odraslih ili pedijatrijskih bolesnika.
English: The most common drug-related clinical adverse experiences reported in paediatric patients treated with caspofungin were pyrexia (11.7%), rash (4.7%) and headache (2.9%).
Croatian: Najčešći štetni događaji povezani s primjenom kaspofungina zabilježeni u pedijatrijskih bolesnika bili su pireksija (11,7%), osip (4,7%) i glavobolja (2,9%).
English: Elderly: A modest increase in AUC (28 %) and C24h (32 %) was observed in elderly male subjects compared with young male subjects.
Croatian: Stariji bolesnici: u starijih muškaraca uočen je umjereni porast AUC-a (28%) i C24h (32%) u usporedbi s mlađim muškarcima.
English: • Treatment of invasive aspergillosis in adult or paediatric patients who are refractory to or intolerant of amphotericin B, lipid formulations of amphotericin B and/or itraconazole.
Croatian: • Liječenje invazivne aspergiloze u odraslih ili pedijatrijskih bolesnika u kojih je izostao odgovor na liječenje ili ne podnose amfotericin B, lipidne pripravke amfotericina B i/ili itrakonazol.
English: Standard preparation (reconstituted Caspofungin Accord added to 250 mL) final concentration
Croatian: Standardna priprema (rekonstituirani Caspofungin Accord dodan u 250 ml otopine) završna koncentracija
English: Other medicines and Caspofungin Accord
Croatian: Drugi lijekovi i Caspofungin Accord
English: Women receiving caspofungin should not breast-feed.
Croatian: Žene koje primaju kaspofungin ne smiju dojiti.
English: These AUC increases are probably due to reduced uptake of caspofungin by the liver.
Croatian: To je povećanje AUC-a vjerojatno posljedica smanjenog ulaska kaspofungina u jetru.
English: Therapy should be continued until up to 72 hours after resolution of neutropaenia (ANC≥500).
Croatian: Liječenje se mora nastaviti do 72 sata nakon prestanka neutropenije (apsolutni broj neutrofila ≥500).
English: SPECIAL STORAGE CONDITIONS Store in a refrigerator.
Croatian: ROK VALJANOSTI Rok valjanosti POSEBNE MJERE ČUVANJA Čuvati u hladnjaku.
English: Patients had to be either refractory to (disease progression or failure to improve with other antifungal therapies given for at least 7 days) (84 % of the enrolled patients) or intolerant of (16 % of enrolled patients) other standard antifungal therapies.
Croatian: Bolesnici su imali infekciju otpornu na liječenje (napredovanje bolesti ili izostanak poboljšanja pri liječenju drugim antimikoticima koje su prethodno primali 7 dana) (84% uključenih bolesnika) ili nisu podnosili druge standardne antimikotike (16% uključenih bolesnika).
English: Both 70 mg and 50 mg vials are available.
Croatian: Dostupne su bočice od 70 mg i 50 mg.
English: PREPARATION OF THE SOLUTION FOR INFUSION IN ADULTS
Croatian: PRIPREMA OTOPINE ZA INFUZIJU ZA ODRASLE
English: Patients in the caspofungin group experienced breakthrough infections due to the following uncommon yeasts and moulds: Trichosporon species (1), Fusarium species (1), Mucor species (1), and Rhizopus species (1).
Croatian: Bolesnici u skupini koja je primala kaspofungin imali su novonastale infekcije prouzročene sljedećim manje čestim kvascima i plijesnima: rod Trichosporon (1), rod Fusarium (1), rod Mucor (1) i rod Rhizopus (1).
English: • Decreased haemoglobin (decreased oxygen carrying substance in the blood), decreased white blood cells
Croatian: • Smanjena razina hemoglobina (smanjena količina tvari koja prenosi kisik u krvi), smanjeni broj bijelih krvnih stanica
English: Caspofungin is extensively bound to albumin.
Croatian: Kaspofungin se opsežno veže za albumin.
English: This is because Caspofungin Accord can affect the way some other medicines work.
Croatian: Caspofungin Accord može utjecati na djelovanje drugih lijekova.
English: • Chills, fever
Croatian: • Zimica, vrućica
English: Rifampicin caused a 60 % increase in AUC and 170 % increase in trough concentration of caspofungin on the first day of co-administration when both medicinal products were initiated together in healthy adult volunteers.
Croatian: Rifampicin je povećao AUC kaspofungina za 60% i povisio najnižu koncentraciju kaspofungina za 170% od prvog dana istodobne primjene ta dva lijeka u zdravih odraslih ispitanika.
English: Hypersensitivity reactions (anaphylaxis and possibly histamine-mediated adverse reactions) have been reported (see section 4.4).
Croatian: Prijavljene su reakcije preosjetljivosti (anafilaksija i nuspojave koje bi mogle biti posredovane histaminom) (vidjeti dio 4.4).
English: Caspofungin acetate inhibits the synthesis of beta (1,3)-D-glucan, an essential component of the cell wall of many filamentous fungi and yeast.
Croatian: Kaspofungin acetat inhibira sintezu beta (1,3)-D-glukana, esencijalne sastavnice stanične stijenke mnogih filamentoznih gljivica i kvasaca.
English: Diluted patient infusion solution: should be used immediately.
Croatian: Razrijeđena otopina za infuziju: mora se odmah primijeniti.
English: Reduced volume infusion (reconstituted Caspofungin Accord added to 100 mL) final concentration
Croatian: Smanjeni volumen infuzije (rekonstituirani Caspofungin Accord dodan u 100 ml otopine) završna koncentracija
English: What Caspofungin Accord looks like and contents of the pack Caspofungin Accord powder for concentrate for solution for infusion is a white to off-white powder.
Croatian: Kako Caspofungin Accord izgleda i sadržaj pakiranja Caspofungin Accord prašak za koncentrat za otopinu za infuziju je bijeli do bjelkasti prašak.
English: A favourable response required both symptom resolution and microbiological clearance of the Candida infection.
Croatian: Povoljan terapijski odgovor sastojao se od povlačenja simptoma i mikrobiološki utvrđenog nestanka infekcije Candidom.
English: Caspofungin undergoes spontaneous degradation to an open ring compound.
Croatian: Kaspofungin se spontano razgrađuje do spoja s otvorenim prstenom.
English: This medicinal product contains sucrose.
Croatian: Ovaj lijek sadrži saharozu.
English: The caspofungin plasma concentrations in these adolescents were reduced relative to adults receiving 70 mg daily, the dose most often administered to adolescents.
Croatian: Koncentracije kaspofungina u plazmi u tih adolescenata bile su manje od onih u odraslih bolesnika koji su primali 70 mg na dan, dozu koja je najčešće primjenjivana u adolescenata.
English: The overall success rates in the MITT analysis results, adjusted by risk strata, were as follows: 46.6 % (26/56) for caspofungin and 32.2 % (8/25) for liposomal amphotericin B.
Croatian: Stope ukupnog uspjeha na temelju rezultata MITT analize, prilagođene prema rizičnim skupinama, bile su sljedeće: 46,6% (26/56) za kaspofungin i 32,2% (8/25) za liposomalni amfotericin B.
English: Caspofungin is not dialysable.
Croatian: Kaspofungin se ne može ukloniti dijalizom.
English: • Loss of appetite, increase in amount of body fluid, imbalance of salt in the body, high sugar level in the blood, low calcium level in the blood, increase calcium level in the blood, low magnesium level in the blood, increase in acid level in the blood
Croatian: • Gubitak teka, povećana količina vode u organizmu, disbalans soli u organizmu, povišeni šećer u krvi, niske razine kalcija u krvi, povišene razine kalcija u krvi, niske razine magnezija u krvi, povišene razine kiseline u krvi
English: Unopened vials: store in a refrigerator 2°C - 8°C).
Croatian: Neotvorene bočice: čuvati u hladnjaku (2°C - 8°C).
English: • Changes in some laboratory blood tests (including increased values of some liver tests)
Croatian: • Promjene nekih laboratorijskih krvnih testova (uključujući povišene vrijednosti nekih jetrenih proba)
English: After reconstitution and dilution, the solution should be administered by slow intravenous infusion over approximately 1 hour.
Croatian: Nakon rekonstitucije i razrjeđivanja otopinu treba primijeniti kao sporu intravensku infuziju u trajanju od približno sat vremena.
English: It is unknown whether caspofungin is excreted in human milk.
Croatian: Nije poznato izlučuje li se kaspofungin u majčino mlijeko.
English: Cardiac disorders tachycardia
Croatian: Srčani poremećaji tahikardija
English: If the 50-mg/m2 daily dose is well tolerated but does not provide an adequate clinical response, the daily dose can be increased to 70 mg/m2 daily (not to exceed an actual daily dose of 70 mg).
Croatian: Ako se dnevna doza od 50 mg/m2 dobro podnosi, ali ne izaziva odgovarajući klinički odgovor, dnevna se doza može povisiti na 70 mg/m2 jedanput na dan (ne smije biti viša od 70 mg na dan).
English: Standardised techniques for susceptibility testing have been established for yeasts by EUCAST.
Croatian: EUCAST je uspostavio standardizirane metode testiranja osjetljivosti za kvasce.
English: In adult patients with moderate liver impairment or in higher weight patients, a dosage adjustment may be necessary (see below).
Croatian: U odraslih bolesnika s umjerenim oštećenjem funkcije jetre i u bolesnika s povećanom tjelesnom težinom može biti potrebno prilagoditi dozu (vidjeti dalje).
English: In the studies involving patients with documented Candida infections, the majority of the patients with invasive Candida infections had serious underlying medical conditions (e.g., haematologic or other malignancy, recent major surgery, HIV) requiring multiple concomitant medications.
Croatian: U ispitivanjima koja su uključivala bolesnike s potvrđenom infekcijom Candidom većina bolesnika s invazivnim infekcijama Candidom imala je ozbiljnu osnovnu bolest (npr. hematološku ili drugu zloćudnu bolest, nedavni veliki operativni zahvat, HIV) zbog čega su morali istodobno primati više lijekova.
English: EUCAST breakpoints have not yet been established for caspofungin, due to significant inter-laboratory variation in MIC ranges for caspofungin.
Croatian: EUCAST granične vrijednosti za kaspofungin još uvijek nisu ustanovljene zbog značajnih varijacija u rasponima MIK vrijednosti za kaspofungin među laboratorijima.
English: • Sensation of fast or irregular heart beats, rapid heart beat, irregular heart beat, abnormal heart rhythm, heart failure
Croatian: • Osjećaj ubrzanih ili nepravilnih otkucaja srca, ubrzani otkucaji srca, nepravilni otkucaji srca, poremećen srčani ritam, zatajenje srca
English: • dexamethasone (a steroid)
Croatian: • deksametazon (steroidni lijek)
English: In some adult and paediatric patients with serious underlying conditions who were receiving multiple concomitant medications with caspofungin, cases of clinically significant hepatic dysfunction, hepatitis and hepatic failure have been reported; a causal relationship to caspofungin has not been established.
Croatian: U nekih odraslih i pedijatrijskih bolesnika s ozbiljnim podležećim stanjima, koji su istodobno s kaspofunginom primali više lijekova, zabilježeni su slučajevi klinički značajnog poremećaja funkcije jetre, hepatitisa i zatajenja jetre; uzročna veza s kaspofunginom nije ustanovljena.
English: Candida species (Candida albicans [N = 1,032], Candida dubliniensis [N = 100], Candida glabrata [N = 151], Candida guilliermondii [N = 67], Candida kefyr [N = 62], Candida krusei [N = 147], Candida lipolytica [N = 20], Candida lusitaniae [N = 80], Candida parapsilosis [N = 215], Candida rugosa [N = 1], and Candida tropicalis [N = 258]), including isolates with multiple resistance transport mutations and those with acquired or intrinsic resistance to fluconazole, amphotericin B, and 5-flucytosine.
Croatian: Candida (Candida albicans [N = 1032], Candida dubliniensis [N = 100], Candida glabrata [N = 151], Candida guilliermondii [N = 67], Candida kefyr [N = 62], Candida krusei [N = 147], Candida lipolytica [N = 20], Candida lusitaniae [N = 80], Candida parapsilosis [N = 215], Candida rugosa
English: Blood and lymphatic system disorders eosinophil count increased
Croatian: Poremećaji krvi i limfnog sustava povećani broj eozinofila
English: This infection is caused by fungal (yeast) cells called Candida.
Croatian: Tu infekciju uzrokuje gljivica (kvasac) pod nazivom Candida.
English: Phlebitis was a commonly reported local injection-site adverse reaction in all patient populations.
Croatian: Flebitis na mjestu primjene bio je često prijavljena nuspojava u svim populacijama bolesnika.
English: Caspofungin is not a substrate for P-glycoprotein and is a poor substrate for cytochrome P450 enzymes.
Croatian: Kaspofungin nije supstrat P-glikoproteina i slab je supstrat enzima citokroma P450.
English: Tell your doctor, nurse or pharmacist if you are taking any of the following medicines:
Croatian: Obavijestite svog liječnika, medicinsku sestru ili ljekarnika ako uzimate neki od navedenih lijekova:
English: Inadvertent administration of up to 400 mg of caspofungin in one day has been reported.
Croatian: Zabilježena je nenamjerna primjena doze do 400 mg kaspofungina u istom danu.
English: Data from 5 clinical studies completed in 171 paediatric patients suggest that the overall incidence of clinical adverse experiences (26.3%; 95% CI -19.9, 33.6) is not worse than reported for adults treated with caspofungin (43.1%; 95% CI -40.0, 46.2).
Croatian: Podaci iz 5 kliničkih ispitivanja sa 171 pedijatrijskim bolesnikom pokazuju da ukupna incidencija klinički štetnih događaja (26,3%; 95% CI -19,9, 33,6) nije lošija nego što je zabilježeno u odraslih bolesnika liječenih kaspofunginom (43,1%; 95% CI -40,0 , 46,2).
English: However, variability was seen in both C1 hr (Day 4 geometric mean 11.73 µg/mL, range 2.63 to 22.05 µg/mL) and C24 hr (Day 4 geometric mean 3.55 µg/mL, range 0.13 to 7.17 µg/mL).
Croatian: Međutim, primijećena je varijabilnost kako C1 h (4. dana geometrijska srednja vrijednost bila je 11,73 µg/ml, raspon od 2,63 do 22,05 µg/ml), tako i u C24 h (4. dana geometrijska srednja vrijednost bila je 3,55 g/ml, raspon od 0,13 do 7,17 µg/ml).
English: Patients in the non-comparative Aspergillus study often had serious predisposing medical conditions (e.g., bone marrow or peripheral stem cell transplants, haematologic malignancy, solid tumours or organ transplants) requiring multiple concomitant medications.
Croatian: Bolesnici u nekomparativnom ispitivanju Aspergillusa često su imali ozbiljno predisponirajuće stanje (npr. transplantaciju koštane srži ili matičnih stanica iz periferne krvi, zloćudnu hematološku bolest, solidni tumor ili presađeni organ) zbog čega su morali primati više različitih lijekova.
English: The second study was a prospective, open-label, non-comparative study estimating the safety and efficacy of caspofungin in paediatric patients (ages 6 months to 17 years) with invasive candidiasis, esophageal candidiasis, and invasive aspergillosis (as salvage therapy).
Croatian: Drugo ispitivanje bilo je prospektivno, otvoreno, nekomparativno ispitivanje djelotvornosti i sigurnosti primjene kaspofungina u pedijatrijskih bolesnika (u dobi od 6 mjeseci do 17 godina) s invazivnom kandidijazom, kandidijazom jednjaka i invazivnom aspergilozom (kao zadnja moguća spasonosna terapija).
English: If you are not sure, talk to your doctor, nurse or pharmacist before you are given your medicine.
Croatian: Ako niste sigurni, obratite se svom liječniku, medicinskoj sestri ili ljekarniku prije nego primite ovaj lijek.
English: Duration of treatment of invasive candidiasis should be based upon the patient's clinical and microbiological response.
Croatian: Trajanje liječenja invazivne kandidijaze mora se temeljiti na kliničkom i mikrobiološkom odgovoru bolesnika.
English: Mix gently until a clear solution is obtained.
Croatian: Nježno miješajte sve dok otopina ne postane potpuno bistra.
English: Other local reactions included erythema, pain/tenderness, itching, discharge, and a burning sensation.
Croatian: Druge lokalne reakcije uključivale su eritem, bol/osjetljivost, svrbež, iscjedak i osjećaj pečenja.
English: In patients who were treated empirically or who had invasive candidiasis, a similar modest effect of age was seen in older patients relative to younger patients.
Croatian: U bolesnika s invazivnom kandidijazom sličan je umjereni učinak uočen u starijih bolesnika u odnosu na mlađe.
English: Repeated dose toxicity studies in rats and monkeys using doses up to 7-8 mg/kg given intravenously showed injection site reactions in rats and monkeys, signs of histamine release in rats, and evidence of adverse effects directed at the liver in monkeys.
Croatian: Ispitivanja toksičnosti ponovljene doze, primijenjene u venu do 7-8 mg/kg kod štakora i majmuna, pokazala su da reakcije na mjestu primjene nastaju u obje vrste, dok su znakovi oslobađanja histamina bili primijećeni kod štakora, a štetni učinci na jetru dokazani kod majmuna.
English: An overall favourable response required meeting each of 5 criteria: (1) successful treatment of any baseline fungal infection (caspofungin 51.9 % [14/27], liposomal amphotericin B 25.9 % [7/27]), (2) no breakthrough fungal infections during administration of study drug or within 7 days after completion of treatment (caspofungin 94.8 % [527/556], liposomal amphotericin B 95.5 % [515/539]), (3) survival for 7 days after completion of study therapy (caspofungin 92.6 % [515/556], liposomal amphotericin B 89.2 % [481/539]), (4) no discontinuation from the study drug because of drug-related toxicity or lack of efficacy (caspofungin 89.7 % [499/556], liposomal amphotericin B 85.5 % [461/539]), and (5) resolution of fever during the period of neutropaenia (caspofungin 41.2 % [229/556], liposomal amphotericin B 41.4 % [223/539]).
Croatian: Ukupni povoljni odgovor sastojao se od zadovoljavanja svakog od sljedećih 5 kriterija: (1) uspješno izlječenje bilo koje gljivične infekcije prisutne na početku liječenja (kaspofungin 51,9% [14/27], liposomalni amfotericin B 25,9% [7/27]), (2) izostanak novonastale gljivične infekcije tijekom primjene ispitivanog lijeka ili u roku od 7 dana nakon završetka liječenja (kaspofungin 94,8% [527/556], liposomalni amfotericin B 95,5% [515/539]), (3) preživljenje 7 dana nakon završetka ispitivane terapije (kaspofungin 92,6% [515/556], liposomalni amfotericin B 89,2% [481/539]), (4) bez prekida primjene ispitivanog lijeka zbog nedjelotvornosti ili toksičnosti lijeka (kaspofungin 89,7% [499/556], liposomalni amfotericin B 85,5% [461/539]) i (5) izostanak vrućice tijekom razdoblja neutropenije (kaspofungin 41,2% [229/556], liposomalni amfotericin B 41,4% [223/539]).
English: The daily maintenance dose should not exceed 70 mg regardless of the patient's calculated dose.
Croatian: Dnevna doza održavanja ne smije biti veća od 70 mg bez obzira na veličinu izračunate doze za bolesnika.
English: Also reported in patients with invasive aspergillosis were pulmonary oedema, adult respiratory distress syndrome (ARDS), and radiographic infiltrates.
Croatian: U bolesnika s invazivnom aspergilozom bili su prijavljeni i plućni edem, respiratorni stres sindrom u odraslih i radiološki vidljivi infiltrati.
English: Moderate (creatinine clearance 31 to 49 mL/min), advanced (creatinine clearance 5 to 30 mL/min), and end-stage (creatinine clearance <10 mL/min and dialysis dependent) renal impairment moderately increased caspofungin plasma concentrations after single-dose administration (range: 30 to 49 % for AUC).
Croatian: Umjerena (klirens kreatinina 31 do 49 ml/min), uznapredovala (klirens kreatinina 5 do 30 ml/min) i terminalna faza (klirens kreatinina <10 ml/min i ovisni o dijalizi) oštećenja funkcije bubrega umjereno su povisile koncentraciju kaspofungina u plazmi nakon primjene pojedinačne doze (raspon: 30-49% za AUC).
English: In limited clinical experience, resistance to caspofungin in patients with invasive aspergillosis has been observed.
Croatian: Ograničena klinička iskustva upućuju na pojavu rezistencije na kaspofungin u bolesnika s invazivnom aspergilozom.
English: In the empirical therapy study patients had received chemotherapy for malignancy or had undergone hematopoietic stem-cell transplantation (including 39 allogeneic transplantations).
Croatian: U ispitivanju empirijskog liječenja sudjelovali su bolesnici koji su primili kemoterapiju zbog maligne bolesti ili su im bile presađene krvotvorne matične stanice (uključujući 39 alogenih transplantacija).
English: Race: Patient pharmacokinetic data indicated that no clinically significant differences in the pharmacokinetics of caspofungin were seen among Caucasians, Blacks, Hispanics, and Mestizos.
Croatian: Rasa: farmakokinetički podaci pokazuju da nema klinički značajnih razlika u farmakokinetici kaspofungina između bijelaca, crnaca, latinoamerikanaca i pripadnika miješanih rasa.
English: Equilibrate the refrigerated vial of Caspofungin Accord to room temperature.
Croatian: Ostavite ohlađenu bočicu lijeka Caspofungin Accord da postigne sobnu temperaturu.
English: However, caspofungin has been shown to interact with other medicinal products in pharmacological and clinical studies (see below).
Croatian: Međutim, u farmakološkim i kliničkim ispitivanjima pokazalo se da kaspofungin ulazi u interakcije s drugim lijekovima (vidjeti u daljnjem tekstu).
English: In a multiple-dose study, a dose reduction of the daily dose to 35 mg in adult patients with moderate hepatic impairment has been shown to provide an AUC similar to that obtained in adult subjects with normal hepatic function receiving the standard regimen (see section 4.2).
Croatian: U ispitivanju višekratnih doza pokazalo se da smanjenje dnevne doze na 35 mg u odraslih bolesnika s umjerenim oštećenjem funkcije jetre osigurava AUC sličnu onoj kakva se dobije u odraslih ispitanika s normalnom funkcijom jetre koji primaju standardni režim (vidjeti dio 4.2).
English: Patients who develop abnormal liver function tests during caspofungin therapy should be monitored for evidence of worsening hepatic function and the risk/benefit of continuing caspofungin therapy should be re-evaluated.
Croatian: Bolesnike u kojih se tijekom liječenja kaspofunginom jave poremećaji u ispitivanjima funkcije jetre potrebno je pomno nadzirati kako bi se uočili znakovi pogoršanja funkcije jetre, te je potrebno ponovno ocijeniti rizik/korist nastavka liječenja kaspofunginom.
English: What you need to know before you are given Caspofungin Accord).
Croatian: Što morate znati prije nego počnete primati Caspofungin Accord ).
English: Hepatobiliary disorders elevated liver enzyme levels (AST, ALT)
Croatian: Poremećaji jetre i žuči povišene razine jetrenih enzima (AST, ALT)
English: As this was a primary therapy study, patients who were refractory to prior antifungal agents were also excluded.
Croatian: Kako je ovo bilo ispitivanje primarne terapije bili su isključeni i bolesnici s infekcijom otpornom na liječenje koja nije reagirala na prijašnju terapiju antimikoticima.
English: This infusion solution must be used within 24 hours if stored at or below 25°C or within 48 hours if stored refrigerated at 2 to 8°C.
Croatian: Ova se infuzijska otopina mora primijeniti u roku od 24 sata ako se čuva pri temperaturi 25°C ili nižoj ili u roku od 48 sati ako se čuva u hladnjaku pri temperaturi od 2°C do 8°C.
English: • Disorientation, feeling nervous, being unable to sleep
Croatian: • Dezorijentiranost, osjećaj nervoze, nesanica