FrancophonIA/ELRC3.0 huggingface dataset:
English: Bupropion 150 mg BID Bupropion Cmax ↓ 51% Bupropion AUC ↓ 56%
Danish: Bupropion 150 mg x 2 Bupropion Cmax ↓ 51% Bupropion AUC ↓ 56%
English: In a pharmacokinetic study performed in healthy volunteers, concomitant use of low dose ritonavir (200 mg twice daily) with a single dose of trazodone led to an increased plasma concentration of trazodone (AUC increased by 2.4 fold).
Danish: Et farmakokinetisk studie med raske frivillige, hvor en enkelt dosis trazodon blev plus lavdosis ritonavir (200 mg 2 gange dagligt), viste øget plasmakoncentration af trazodon (AUC steg 2,4 gange).
English: Inhibition of CYP 3A4 by atazanavir/ritonavir and induction by tipranavir/r.
Danish: CYP3A4 hæmmes af atazanavir/ritonavir og induceres af tipranavir/r.
English: If unavoidable, upward dose adjustments for either omeprazole or esomeprazole may be considered based on clinical response to therapy.
Danish: Hvis samtidig administration ikke kan undgås, kan det overvejes at øge dosis af enten omeprazol eller esomeprazol baseret på det kliniske respons af behandlingen.
English: Tell your child's doctor if your child receives medicines such as blood-thinning agents, or if your child is taking vitamin E. Your child's doctor may wish to consider certain precautionary measures in such circumstances.
Danish: Fortæl lægen, hvis dit barn tager medicin, der fortynder blodet eller hvis dit barn tager vitamin E. Lægen vil i sådanne tilfælde overveje en alternativ medicinering.
English: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Danish: Hos nogle patienter med fremskreden hiv-infektion (aids), der tidligere har haft hiv-relaterede infektioner (opportunistiske infektioner), kan der kort tid efter, at anti-hiv-behandlingen er begyndt, forekomme tegn og symptomer på betændelsesreaktioner (inflammation) fra tidligere infektioner.
English: Your child must take Aptivus together with ritonavir.
Danish: Dit barn skal tage Aptivus sammen med ritonavir.
English: Respiratory, thoracic and mediastinal disorders uncommon dyspnoea
Danish: Luftveje, thorax og mediastinum Ikke almindelig dyspnø
English: HMG CoA reductase inhibitors Atorvastatin 10 mg QD Atorvastatin Cmax ↑ 8.6 fold Atorvastatin AUC ↑ 9.4 fold Atorvastatin Cmin ↑ 5.2 fold
Danish: HMG-CoA-reduktasehæmmere Atorvastatin 10 mg x 1 Atorvastatin Cmax ↑ 8,6 gange Atorvastatin AUC ↑ 9,4 gange Atorvastatin Cmin ↑ 5,2 gange
English: Aptivus is available as soft capsules for adults and adolescents from 12 years of age (please refer to the respective SmPC for further details).
Danish: Aptivus kan fås som bløde kapsler til voksne og unge fra 12 år (jf. produktresumé for Aptivus kapsler).
English: Itraconazole Ketoconazole No interaction study performed
Danish: Itraconazol Ketoconazol Der er ikke udført interaktionsstudier
English: The effect of tipranavir with low dose of ritonavir on the QTcF interval was measured in a study in which 81 healthy subjects received the following treatments twice daily for 2.5 days: tipranavir/ritonavir (500/200 mg), tipranavir/ritonavir at a supra-therapeutic dose (750/200 mg), and placebo/ritonavir (-/200 mg).
Danish: I et klinisk studie blev indvirkningen af tipranavir plus lavdosis ritonavir på QTcF-intervallet målt hos 81 raske personer, der blev behandlet 2 gange daglig i 2½ dag med følgende doser: Tipranavir/ritonavir (500/200 mg), tipranavir/ritonavir i supraterapeutisk dosis (750/200 mg) og placebo/ritonavir (-/200 mg).
English: When co-administered, tipranavir and cobicistat exposures are markedly lower compared to that of tipranavir when boosted with low dose ritonavir.
Danish: Ved samtidig administration er tipranavir- og cobicistateksponeringerne markant lavere, end når tipranavir er forstærket med lavdosis ritonavir.
English: The superiority of tipranavir co-administered with low dose ritonavir over the comparator protease inhibitor/ritonavir arm was observed for all efficacy parameters at week 48.
Danish: Overlegenheden ved tipranavir indplus lavdosis ritonavir i forhold til komparatorproteasehæmmer/ritonavir-gruppen sås efter 48 uger for alle effektparametre.
English: Mean decrease in viral load from baseline to week 48, according to tipranavir baseline mutation score and enfuvirtide use in RESIST patients
Danish: Gennemsnitligt fald i virusmængde fra baseline til uge 48 i henhold til tipranavir baselinemutationsscore og anvendelse af enfuvirtid til RESIST-patienter
English: It has to be noted that the switch from the oral solution to the capsule formulation of Aptivus could be associated with decreased exposure.
Danish: Behandlingsskift fra Aptivus oral opløsning til kapsler kan være forbundet med en reduceret eksponering.
English: It belongs to a group of medicines called protease inhibitors and is used in the treatment of Human Immunodeficiency Virus (HIV) infection.
Danish: Det er en proteasehæmmer, der bruges til behandling af hiv (human immunedefektvirus)-infektion.
English: The in vivo net effect of tipranavir with ritonavir on CYP 1A2, CYP 2C9 and CYP 2C19, indicates, through a preliminary study, an inducing potential of tipranavir with ritonavir on CYP1A2 and, to a lesser extent, on CYP2C9 and P-gp after several days of treatment.
Danish: Et præliminært studium tyder på, at nettovirkningen in vivo af tipranavir med ritonavir på CYP1A2, CYP2C9 og CYP2C19, består i, at tipranavir med ritonavir efter flere dages behandling kan inducere CYP1A2 og i mindre grad CYP2C9 og P-gp.
English: Aptivus oral solution should be taken with food.
Danish: Aptivus oral opløsning skal tages sammen med mad.
English: Rash gamma GT increased ALAT increased
Danish: Forhøjet gamma GT Forhøjet ALAT Anæmi
English: Aptivus co-administered with low dose ritonavir, has been associated with reports of significant liver toxicity.
Danish: Aptivus plus lavdosis ritonavir er blevet forbundet med rapporter om signifikant levertoksicitet.
English: Macrogolglycerol ricinoleate Ethanol
Danish: Polyoxyleret ricinusolie Ethanol
English: Therefore, patients should be monitored for opiate withdrawal syndrome.
Danish: Patienterne bør derfor monitoreres for opiatlignende abstinenssymptomer.
English: Always give your child this medicine exactly as the doctor has advised.
Danish: Dit barn skal altid tage lægemidlet nøjagtigt efter lægens anvisning.
English: Tell your doctor if you receive medicines such as blood-thinning agents, or if you are taking vitamin E. Your doctor may wish to consider certain precautionary measures in such circumstances.
Danish: Fortæl det altid til lægen, hvis du tager medicin, derfortynder blodet eller hvis du tager vitamin E. Din læge vil i sådanne tilfælde overveje en alternativ medicinering.
English: Whilst the changes in clarithromycin parameters are not considered clinically relevant, the reduction in the 14-OH metabolite AUC should be considered for the treatment of infections caused by Haemophilus influenzae in which the 14-OH metabolite is most
Danish: Selvom ændringerne i clarithromycin-parametre ikke anses for klinisk relevante, bør reduktionen af AUC for 14-OHmetabolitten tages med i overvejelserne ved behandling af infektioner forårsaget af
English: - If your child gets any side effects, talk to your child's doctor or pharmacist.
Danish: Hvis dit barn oplever bivirkninger, bør du tale med barnets læge eller apoteket.
English: Phenobarbital Phenytoin No interaction study performed
Danish: Phenobarbital Phenytoin Der er ikke udført interaktionsstudier.
English: Tipranavir Cmax ↓ 25% Tipranavir AUC ↓ 27% Mechanism unknown
Danish: Tipranavir Cmax ↓ 25% Tipranavir AUC ↓ 27% Ukendt virkningsmekanisme
English: Oral contraceptives / Oestrogens Ethinyl oestradiol 0.035 mg / Norethindrone 1.0 mg QD (TPV/r 750/200 mg BID)
Danish: Oral antikonception/ Østroger Ethinylestradiol 0,035 mg / Norethisteron 1,0 mg x 1 (TPV/r 750/200 mg x 2)
English: Aptivus oral solution is available for children between 2 and 12 years of age (please refer to the respective SmPC for further details).
Danish: Aptivus oral opløsning er tilgængelig for børn i alderen mellem 2 og 12 år (jf. det respektive produktresumé).
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each soft capsule contains 250 mg tipranavir.
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING En blød kapsel indeholder 250 mg tipranavir.
English: - The other ingredients are macrogolglycerol ricinoleate, ethanol (alcohol), mono/diglycerides of caprylic/capric acid, propylene glycol, purified water, trometamol and propyl gallate.
Danish: - Øvrige indholdsstoffer: Polyoxyleret ricinusolie, ethanol (alkohol), mono-/diglycerider af caprylsyre/caprinsyre, propylenglykol, renset vand, trometamol og propylgallat.
English: Inhibition of CYP 2C9 with firstdose tipranavir /r, then induction of CYP 2C9 with steady-state tipranavir/r
Danish: Initialt ses en hæmning af CYP2C9 med første-dosis af tipranavir/r, herefter induktion af CYP2C9 med steady-state tipranavir/r
English: Didanosine Cmax ↓ 24% Didanosine AUC ↔
Danish: Didanosin Cmax ↓ 24% Didanosin AUC ↔
English: Since the renal clearance of tipranavir is negligible, increased plasma concentrations are not expected in patients with renal impairment.
Danish: Da den renale clearance af tipranavir er minimal, forventes plasmakoncentrationerne ikke at stige hos patienter med nedsat nyrefunktion.
English: Primary PI mutations
Danish: - Primære proteasehæmmermutationer
English: If there is more than a thin layer of crystals at the bottom of the bottle or uncertainty about the amount of crystals observed, the bottle should be returned for a replacement as soon as possible.
Danish: Hvis krystalmængden er mere udtalt, eller der er uklarhed om hvorvidt mængden af krystaller i flaskebunden har betydning, skal flasken udskiftes med en anden.
English: Co-administration of Aptivus and low dose ritonavir with agents primarily metabolised by CYP3A may result in changed plasma concentrations of tipranavir or the other agents, which could alter their therapeutic and undesirable effects (see list and details of considered agents, below).
Danish: Samtidig administration af Aptivus og lavdosis ritonavir med midler, der primært metaboliseres af CYP3A, kan resultere i ændrede plasmakoncentrationer af tipranavir eller de andre midler, som kan få ændret deres terapeutiske virkning og uønsket hændelser (se nedenstående liste med detaljer over berørte midler).
English: The clinical relevance of this reduction has not been established, but may decrease the efficacy of zidovudine.
Danish: Den kliniske relevans af reduktionen er ikke fastlagt, men muligvis mindskes effekten af zidovudin.
English: Aptivus, co-administered with low dose ritonavir, is indicated for combination antiretroviral treatment of HIV-1 infection in highly pre-treated adults and adolescents 12 years of age or older with virus resistant to multiple protease inhibitors.
Danish: Aptivus plus lavdosis ritonavir er indiceret som antiretroviral kombinationsbehandling af hiv-1 infektion til tidligere behandlede voksne og unge fra 12 års alderen, der er smittede med virus, som er resistent over for flere proteasehæmmere.
English: C-tipranavir to subjects (n = 8) that received 500 mg tipranavir with 200 mg ritonavir; twice daily dosed to steady-state demonstrated that most radioactivity (median 82.3%) was excreted in faeces, while only a median of 4.4% of the radioactive dose administered was recovered in urine.
Danish: C-tipranavir til patienter (n=8), som fik 500 mg tipranavir med 200 mg ritonavir; to gange daglig, viste ved steady state, at størstedelen af radioaktiviteten (middel 82,3%) blev udskilt i fæces, hvorimod kun gennemsnitlig 4,4% blev genfundet i urinen.
English: Reverse genetic experiments showed that the presence of 6 mutations in the protease (I13V, V32I, L33F, K45I, V82L, I84V) was required to confer > 10-fold resistance to tipranavir while the full 10-mutation genotype conferred 69-fold resistance to tipranavir.
Danish: Reverse genetiske studier viste, at det var nødvendigt med tilstedeværelsen af 6 mutationer i proteasen (I13V, V32I, L33F, K45I, V82L, I84V) for at øge resistensen over for tipranavir >10 gange, mens 10mutationsgenotypen øgede resistensen over for tipranavir 69 gange.
English: It is unknown whether the combination of tipranavir with ritonavir might cause a larger increase in fluticasone exposure.
Danish: Det er uvist, om kombinationen af tipranavir med ritonavir kan forårsage en øget påvirkning af fluticason.
English: If you have haemophilia type A and B, you may experience increased bleeding.
Danish: Hos patienter med blødersygdom type A eller B, kan der være en øget risiko for blødning.
English: Aptivus 100 mg/ml oral solution tipranavir
Danish: Aptivus 100 mg/ml oral opløsning tipranavir
English: Clinical data on fertility are not available for tipranavir.
Danish: Der findes ingen kliniske data for tipranavirs indvirkning på fertilitet.
English: Increasing baseline phenotypic fold change to tipranavir in isolates is correlated to decreasing virological response.
Danish: Hvis der i isolater ses en stigning i baseline fænotypiske ændringer pga. tipranavir, er det tegn på nedsat virologisk respons.
English: Check with your child's doctor or pharmacist if you are not sure.
Danish: Spørg dit barns læge eller apotekspersonalet, hvis der er noget du er i tvivl om.
English: Caution should be exercised when administering Aptivus to patients with liver enzyme abnormalities or with a history of hepatitis.
Danish: Der skal udvises forsigtighed, når der gives Aptivus til patienter med abnorme leverenzymer eller tidligere hepatitis.
English: Patients treated with Aptivus and reaching the age of 12 years should be switched to the capsule formulation (see sections 4.4 and 5.1).
Danish: Patienter i behandling med Aptivus, som bliver 12 år bør skiftes over på kapselformuleringen (se pkt.
English: What Aptivus looks like and contents of the pack Aptivus soft capsules are pink coloured, oblong soft gelatin capsules with a black print imprint of ‘TPV 250'.
Danish: Aptivus bløde kapsler er lyserøde, aflange bløde gelatinekapsler med et sort påtrykt mærke TPV 250.
English: However, it is unknown whether the combination of tipranavir with
Danish: Det er uvist, om kombinationen af tipranavir med ritonavir kan
English: Aptivus therapy should not be initiated in patients with pre-treatment ASAT or ALAT greater than 5 times the Upper Limit Normal (ULN) until baseline ASAT/ALAT is stabilised at less than 5X ULN, unless the potential benefit justifies the potential risk.
Danish: Der bør ventes til ASAT/ALAT ved baseline er stabiliseret til mindre end 5 gange ULN, medmindre den potentielle fordel opvejer den potentielle risiko.
English: The interaction profile of tipranavir, co-administered with low dose ritonavir, is complex.
Danish: Interaktionsprofilen for tipranavir plus lavdosis ritonavir er kompleks.
English: Aptivus, co-administered with low dose ritonavir, should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other medical conditions, or who are receiving medicinal products known to increase the risk of bleeding such as antiplatelet agents and anticoagulants or who are taking supplemental vitamin E. Patients taking Aptivus oral solution should be advised not to take any supplemental vitamin E.
Danish: Aptivus plus lavdosis ritonavir bør gives med forsigtighed til patienter, med risiko for øget blødning efter trauma, operation eller andre medicinske tilstande, eller indtager lægemidler, som er kendt for at øge blødningstendensen såsom antitrombotisk og antikoagulant behandling eller som tager supplerende vitamin E. Patienter, som er i behandling med Aptivus oral opløsning bør adviseres om ikke at tage vitamin E tilskud.
English: The safety and efficacy of Aptivus capsules in children aged 2 to 12 years has not been established.
Danish: Aptivus kapslers sikkerhed og virkning hos børn i alderen fra 2 til 12 år er ikke klarlagt.
English: 25-O-desacetylrifabutin Cmax ↑ 3.2 fold
Danish: 25-O-desacetylrifabutin Cmax ↑ 3,2 gang
English: R-methadone Cmax ↓ 46% R-methadone AUC ↓ 48%
Danish: R-metadon Cmax ↓ 46% R-metadon AUC ↓ 48%
English: First-dose tipranavir/r Digoxin Cmax ↑ 93% Digoxin AUC ↑ 91%
Danish: Første dosis tipranavir/r: Digoxin Cmax ↑ 93% Digoxin AUC ↑ 91%
English: Tipranavir phenotypic resistance
Danish: - Tipranavir fænotypisk resistens
English: Tipranavir, co-administered with low dose ritonavir, increases the plasma concentrations of atorvastatin (see section 4.5).
Danish: Tipranavir plus lavdosis ritonavir øger plasmakoncentrationen af atorvastatin (se pkt.
English: If you take other medicines at the same time as Aptivus and ritonavir, this can strengthen or weaken the effect of the medicines.
Danish: Dette er meget vigtigt, idet indtagelse af visse typer medicin sammen med Aptivus og ritonavir kan forstærke eller svække effekten af medicinen.
English: Plasma concentrations of tipranavir can be reduced by concomitant use of the herbal preparation St John's wort (Hypericum perforatum).
Danish: Plasmakoncentrationerne for tipranavir kan blive nedsat ved samtidig brug af naturlægemidlet perikon (Hypericum perforatum).
English: As a result of CYP3A4 inhibition and CYP2C19 induction by tipranavir/r, lansoprazole and pantoprazole plasma concentrations are difficult to predict.
Danish: Da tipranavir/r hæmmer CYP3A4 og inducerer CYP2C19, kan det være vanskeligt at forudse plasmakoncentrationerne for lansoprazol og pantoprazol.
English: Concomitant use of rilpivirine with some ritonavir-boosted protease inhibitors has demonstrated an increase in the plasma concentrations of rilpivirine.
Danish: rilpivirin og nogle ritonavirforstærkede proteasehæmmere har medført en stigning i rilpivirinplasmakoncentrationen.
English: If your child takes aluminium- and magnesium-based antacid (used to treat dyspepsia/ gastrooesophageal reflux), the time interval between Aptivus and antacid should be at least two hours.
Danish: Hvis dit barn tager et aluminium- eller magnesiumholdigt syreneutraliserende middel (anvendes til behandling af for meget mavesyre/sure opstød), skal tidsintervallet mellem indtagelse af Aptivus og det syreneutraliserende middel være mindst to timer.
English: Midazolam 5 mg QD (po)
Danish: Midazolam 5 mg x 1 (p.o.)
English: Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu/
Danish: DATO FOR ÆNDRING AF TEKSTEN Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu og på Lægemiddelstyrelsens hjemmeside http://www.laegemiddelstyrelsen.dk.
English: low dose ritonavir (this helps Aptivus to reach a high enough level in your child's blood) other HIV medicines.
Danish: - Lavdosis ritonavir (kombinationen er nødvendig, for at sikre optimal virkning af Aptivus i dit barns blod) - Anden medicin mod hiv.
English: Open the bottle by pressing down on the cap and turning in an anti-clockwise direction.
Danish: Flasken åbnes ved at presse låget ned og dreje mod uret.
English: Co-administration of Aptivus/ritonavir with sildenafil, when used to treat pulmonary arterial hypertension, is contraindicated.
Danish: Samtidig administration af Aptivus/ritonavir og sildenafil til behandling af pulmonal arteriel hypertension er kontraindiceret.
English: This score has been determined from the selected RESIST patient population having specific mutation inclusion criteria and therefore extrapolation to a wider population mandates caution.
Danish: Denne score er fastlagt på basis af den udvalgte RESIST-patientpopulation, der har specifikke mutationsinklusionskriterier.
English: In an open-label, dose-finding study of tipranavir plus ritonavir (Trial 1182.14), 62 children aged 2 to 12 years received Aptivus oral solution.
Danish: I studie 1182.14, et åbent dosisbestemmelsesstudie med tipranavir og ritonavir, fik 62 børn på 2 til 12 år tipranavir oral opløsning.
English: Co-administration of protease inhibitors with rifampicin substantially decreases protease inhibitor concentrations.
Danish: Samtidig behandling af proteasehæmmere med rifampicin medfører et væsentligt fald i koncentrationen af proteasehæmmere.
English: The capsule shell contains gelatin, red iron oxide, propylene glycol, purified water, ‘sorbitol special-glycerin blend' (d-sorbitol, 1,4 sorbitan, mannitol and glycerin) and titanium dioxide.
Danish: Selve kapslen består af gelatine, rød jernoxid (E172), propylenglykol, renset vand, ”sorbitol-specialglycerinblanding” (d-sorbitol, 1,4-sorbitan, mannitol og glycerin) og titandioxid (E 171).
English: Recommendations for maximal doses of omeprazole or esomeprazole are found in the corresponding product information.
Danish: Der henvises til produktinformationerne for omeprazol eller esomeprazol vedrørende maksimale dosisanbefalinger.
English: Patients had baseline HIV-1 isolates with a median of 16 HIV-1 protease gene mutations, including a median of 3 primary protease gene mutations D30N, L33F/I, V46I/L, G48V, I50V, V82A/F/T/L, I84V, and L90M.
Danish: Patienterne havde baseline hiv-1-isolater med en median på 16 hiv-1-proteasegenmutationer, herunder en median af 3 primære proteasegenmutationer D30N, L33F/L, V461/L, G48V, I50V, V82A/F/T/L, I84V og L90M.
English: Key efficacy results at 48 weeks for patients 12 - 18 years of age who took capsule Endpoint
Danish: De vigtigste resultater ved uge 48 for patienter fra 12 - 18 år, som blev behandlet med kapsler
English: Therefore, tipranavir with ritonavir should not be used in treatment-naïve patients (see section 4.2).
Danish: Derfor bør tipranavir med ritonavir ikke anvendes til behandlingsnaive patienter (se. pkt.
English: The black printing ink contains propylene glycol, black iron oxide, polyvinyl acetate phthalate, macrogol and ammonium hydroxide.
Danish: Det sorte blæk indeholder propylenglykol, sort jernoxid (E172), polyvinylacetatphthalat, makrogol og ammoniumhydroxid.
English: Aptivus, co-administered with low dose ritonavir, should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other medical conditions, or who are receiving medicinal products known to increase the risk of bleeding such as antiplatelet agents and anticoagulants or who are taking supplemental vitamin E. Based on the limits of exposure available from observation in clinical trials, it is recommended not to co-administer to patients more than 1,200 IU vitamin E per day.
Danish: Aptivus plus lavdosis ritonavir bør gives med forsigtighed til patienter, med risiko for øget blødning efter trauma, operation eller andre medicinske tilstande, eller indtager lægemidler, som er kendt for at øge blødningstendensen såsom antitrombotisk og antikoagulant behandling eller som tager supplerende vitamin E. Baseret på et begrænset patientmateriale fra kliniske studier anbefales det højst at administrere 1.200 IU vitamin E per dag til patienter.
English: If your child suffers increased bleeding you should see your child's doctor immediately.
Danish: Hvis dit barn får en øget blødningstendens, skal du kontakte lægen straks.
English: Your doctor will only prescribe you abacavir and zidovudine if you are unable to take other NRTIs.
Danish: Du vil kun få ordineret abacavir og zidovudin, hvis du ikke kan tåle andre NRTI-midler.
English: 25-O-desacetylrifabutin Cmin ↑ 7.8 fold
Danish: 25-O-desacetylrifabutin Cmin ↑ 7,8 gang
English: C-tipranavir with 200 mg ritonavir, twice daily), unchanged tipranavir was predominant and accounted for 98.4% or greater of the total plasma radioactivity circulating at 3, 8, or 12 hours after dosing.
Danish: C-tipranavir med 200 mg ritonavir; to gange daglig), udgjorde uomdannet tipranavir 98,4% eller mere af den totale cirkulerende plasmaradioaktivitet, 3, 8 eller 12 timer efter dosering.
English: Until the bottle is exchanged the patient should continue to take the usual doses of the oral solution.
Danish: Patienten skal fortsætte med at tage den sædvanlige dosis af den orale opløsning, indtil flasken er udskiftet.