FrancophonIA/ELRC3.0 huggingface dataset:
English: ART-experienced paediatric patients (3 to 17 years of age and weighing at least 15 kg) Darunavir twice daily taken with ritonavir taken with food is usually recommended.
Slovenian: Pediatrični bolniki (stari 3 do 17 let in s telesno maso najmanj 15 kg), ki že imajo izkušnje z ART Običajno priporočeno odmerjanje je darunavir dvakrat na dan, skupaj z ritonavirjem, s hrano.
English: With baseline CD4+ cell count <
Slovenian: št. celic CD4+ <
English: Refer to section 4.4 if creatinine clearance is used for dose adjustment of emtricitabine or lamivudine.
Slovenian: Če očistek kreatinina uporabljate za prilagajanje odmerka emtricitabina ali lamivudina, glejte poglavje 4.4.
English: Darunavir co-administered with low dose ritonavir can be expected to increase the plasma concentrations of calcium channel blockers.
Slovenian: Pričakovati je, da darunavir skupaj z majhnim odmerkom ritonavirja zviša plazemske koncentracije zaviralcev kalcijevih kanalčkov.
English: Increased CPK, myalgia, myositis and rarely, rhabdomyolysis have been reported with the use of protease inhibitors, particularly in combination with NRTIs.
Slovenian: Pri uporabi zaviralcev proteaz, še posebej pri kombiniranju z NRTI, so poročali o zvišanih vrednostih CPK, mialgiji, miozitisu in redko rabdomiolizi.
English: Take Darunavir Krkawith food.
Slovenian: - Zdravilo Darunavir Krka jemljite s hrano.
English: Carbamazepine 200 mg twice daily carbamazepine AUC ↑ 45% carbamazepine Cmin ↑ 54% carbamazepine Cmax ↑ 43% darunavir AUC ↔ darunavir Cmin ↓ 15% darunavir Cmax ↔
Slovenian: karbamazepin 200 mg dvakrat na dan karbamazepin AUC ↑ 45 % karbamazepin Cmin ↑ 54 % karbamazepin Cmax ↑ 43 % darunavir AUC ↔ darunavir Cmin ↓ 15 % darunavir Cmax ↔
English: Take Darunavir Krka always together with 100 milligram of ritonavir.
Slovenian: - Zdravilo Darunavir Krka vzemite vedno skupaj s 100mg ritonavirja.
English: (CYP450 induction)
Slovenian: (induciranje CYP450)
English: (CYP3A induction)
Slovenian: (induciranje CYP3A)
English: Concomitant use of salmeterol and boosted darunavir is not recommended.
Slovenian: Sočasna uporaba salmeterola in okrepljenega darunavirja ni priporočljiva.
English: Rifapentine and rifampicin are strong CYP3A inducers and have been shown to cause profound decreases in concentrations of other protease inhibitors, which can result in virological failure and resistance development (CYP450 enzyme induction).
Slovenian: Dokazano je bilo, da povzročata precejšnje zmanjšanje koncentracij drugih zaviralcev proteaz, kar tega lahko vodi v virološko neuspešnost in razvoj odpornosti (indukcija CYP450).
English: If efavirenz is to be used in combination with darunavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used (see section 4.5).
Slovenian: Če je treba kombinirati efavirenz in zdravilo darunavir, je treba uporabljati režim darunavir/ritonavir 600/100 mg dvakrat na dan (glejte poglavje 4.5).
English: Darunavir must always be given orally with cobicistat or low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products (see section 5.2).
Slovenian: Darunavir se mora vedno uporabljati peroralno, s kobicistatom ali z majhnim odmerkom ritonavirja kot farmakokinetičnim ojačevalcem in v kombinaciji z drugimi protiretrovirusnimi zdravili (glejte poglavje 5.2).
English: Darunavir Krka 400 mg and 800 mg tablets can be used to construct the once daily 800 mg regimen.
Slovenian: Darunavir Krka 400 mg in 800 mg tablete lahko uporabljate za režim odmerjanja 800 mg enkrat na dan.
English: For patients with renal impairment the Summary of Product Characteristics for clarithromycin should be consulted for the recommended dose.
Slovenian: Za priporočila za odmerjanje klaritromicina pri bolnikih z okvaro ledvic glejte Povzetek glavnih značilnosti zdravila za klaritromicin.
English: Nervous system disorders common headache, peripheral neuropathy, dizziness uncommon lethargy, paraesthesia, hypoaesthesia, dysgeusia, disturbance in attention, memory impairment, somnolence rare syncope, convulsion, ageusia, sleep phase rhythm disturbance
Slovenian: Bolezni živčevja pogosti glavobol, periferna nevropatija, omotica občasni letargija, parestezija, hipestezija, disgevzija, motnje pozornosti, poslabšanje spomina, zaspanost redki sinkopa, konvulzije, agevzija, motnje spalnega ritma
English: Reproductive system and breast disorders uncommon gynaecomastia*
Slovenian: Motnje reprodukcije in dojk občasni ginekomastija*
English: Concomitant administration of boosted darunavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity.
Slovenian: Sočasna uporaba okrepljenega darunavirja in kvetiapina je kontraindicirana, ker lahko zveča s kvetiapinom povezano toksičnost.
English: Warfarin concentrations may be affected when co-administered with darunavir with low dose ritonavir.
Slovenian: Koncentracije varfarina so lahko spremenjene ob sočasni uporabi darunavirja z majhnim odmerkom ritonavirja.
English: Carbamazepine, clonazepam(to prevent seizures or to treat certain types of nerve pain) Colchicine (to treat gout or familial Mediterranean fever) Bosentan (to treat high blood pressure in the pulmonary circulation) Buspirone, clorazepate, diazepam, estazolam, flurazepam, midazolam when used as injection, zoldipem (sedative agents)
Slovenian: (za zdravljenje depresije in tesnobe) - maravirok(za zdravljenje okužbe z virusomHIV) - metadon(za zdravljenje odvisnosti od opioidov) - karbamazepin, klonazepam(za preprečevanje epileptičnih napadov ali za zdravljenje določenih vrst nevrološke bolečine) - kolhicin (za zdravljenje protina ali družinske mediteranske mrzlice) - bosentan(za zdravljenje visokega krvnega tlaka v pljučnem krvnem obtoku) - buspiron, klorazepat, diazepam, estazolam, flurazepam, midazolam, kadar se ne uporablja v obliki injekcije, zoldipem (pomirjevala) - perfenazin, risperidon, tioridazin(za zdravljenjepsihiatričnih stanj)
English: Co-administration of darunavir/ritonavir with medicinal products primarily metabolised by CYP3A and/or CYP2D6 or transported by P-gp may result in increased systemic exposure to such medicinal products, which could increase or prolong their therapeutic effect and adverse reactions.
Slovenian: Sočasna uporaba učinkovin darunavir/ritonavir z zdravili, ki se presnavljajo predvsem s CYP3A in/ali CYP2D6 ali jih prenaša P-gp, lahko povzroči zvečano sistemsko izpostavljenost takšnim zdravilom, kar bi lahko zvečalo ali podaljšalo njihov terapevtski učinek in neželene učinke.
English: Based on theoretical considerations boosted darunavir may increase plasma concentrations of these analgesics.
Slovenian: Po teoretični presoji lahko sočasna uporaba okrepljenega zdravila darunavir zviša plazemske koncentracije navedenih analgetikov.
English: Dabigatran Ticagrelor
Slovenian: dabigatran tikagrelor
English: ART-naïve paediatric patients (3 to 17 years of age and weighing at least 15 kg) The weight-based dose of darunavir and ritonavir in paediatric patients is provided in the table below.
Slovenian: Pediatrični bolniki, ki še nimajo izkušenj z ART (stari 3 do 17 let in s telesno maso najmanj 15 kg) Odmerek darunavirja in ritonavirja glede na telesno maso pri pediatričnih bolnikih je naveden v spodnji preglednici.
English: Following intravenous administration, the volume of distribution of darunavir alone was 88.1 ± 59.0 l (Mean ± SD) and increased to 131 ± 49.9 l (Mean ± SD) in the presence of 100 mg twice-daily ritonavir.
Slovenian: Po intravenskem dajanju je bil volumen porazdelitve samega darunavirja 88,1 ± 59,0 l (povprečna vrednost ± SD).
English: (CYP3A, CYP2D6 and/or P-gp inhibition)
Slovenian: (zaviranje CYP3A, CYP2D6 in/ali P-gp)
English: Lopinavir/ritonavir 533/133.3 mg twice daily lopinavir AUC ↑ 9% lopinavir Cmin ↑ 23% lopinavir Cmax ↓ 2% darunavir AUC ↓ 38% darunavir Cmin ↓ 51% darunavir Cmax ↓ 21% lopinavir AUC ↔ lopinavir Cmin ↑ 13% lopinavir Cmax ↑ 11% darunavir AUC ↓ 41% darunavir Cmin ↓ 55% darunavir Cmax ↓ 21% based upon non dose normalised values
Slovenian: 400/100 mg dvakrat na dan lopinavir/ritonavir 533/133.3 mg dvakrat na dan lopinavir AUC ↑ 9 % lopinavir Cmin ↑ 23 % lopinavir Cmax ↓ 2 % darunavir AUC ↓ 38 % darunavir Cmin ↓ 51 % darunavir Cmax ↓ 21 % lopinavir AUC ↔ lopinavir Cmin ↑ 13 % lopinavir Cmax ↑ 11 % darunavir AUC ↓ 41 % darunavir Cmin ↓ 55 % darunavir Cmax ↓ 21 %
English: 600 mg once daily efavirenz Cmin ↑ 17% efavirenz Cmax ↑ 15% darunavir AUC ↓ 13% darunavir Cmin ↓ 31% darunavir Cmax ↓ 15% (↑ efavirenz from CYP3A inhibition) (↓ darunavir from CYP3A induction)
Slovenian: 600 mg enkrat na dan efavirenz AUC ↑ 21 % efavirenz Cmin ↑ 17 % efavirenz Cmax ↑ 15 % darunavir AUC ↓ 13 % darunavir Cmin ↓ 31 % darunavir Cmax ↓ 15 % (↑ efavirenza zaradi zaviranja CYP3A) (↓ darunavirja zaradi indukcije CYP3A)
English: The overall pharmacokinetic enhancement effect by ritonavir was an approximate 14-fold increase in the systemic exposure of darunavir when a single dose of 600 mg darunavir was given orally in combination with ritonavir at 100 mg twice daily (see section 4.4).
Slovenian: Skupni učinek farmakokinetične okrepitve z ritonavirjem je bil približno 14-kratno zvečanje sistemske izpostavljenosti darunavirju pri peroralni uporabi enkratnega odmerka 600 mg darunavirja v kombinaciji z ritonavirjem v odmerku 100 mg dvakrat na dan (glejte poglavje 4.4).
English: Darunavir co-administered with cobicistat lowers the creatinine clearance.
Slovenian: Darunavir v kombinaciji s kobicistatom zmanjša očistek kreatinina.
English: Vascular disorders uncommon hypertension, flushing
Slovenian: Žilne bolezni občasni hipertenzija, rdečica
English: Saquinavir 1,000 mg twice daily darunavir AUC ↓ 26% darunavir Cmin ↓ 42% darunavir Cmax ↓ 17% saquinavir AUC ↓ 6% saquinavir Cmin ↓ 18% saquinavir Cmax ↓ 6% Saquinavir: comparison of saquinavir/ritonavir 1,000/100 mg twice
Slovenian: sakvinavir 1.000 mg dvakrat na dan darunavir AUC ↓ 26 % darunavir Cmin ↓ 42 % darunavir Cmax ↓ 17 % sakvinavir AUC ↓ 6 % sakvinavir Cmin ↓ 18 % sakvinavir Cmax ↓ 6 % sakvinavir: primerjava jemanja učinkovin sakvinavir/ritonavir 1.000/100mgdvakrat na dan s kombinacijo
English: For clinical trial results in ART-naïve paediatric patients aged 12 to 17 years, refer to the Summary of Product Characteristics for Darunavir Krka 400 mg and 800 mg tablets.
Slovenian: Za rezultate kliničnih preskušanj pri bolnikih, ki nimajo izkušenj z ART, starih 12 do 17 let, glejte Povzetek glavnih značilnosti zdravila Darunavir Krka 400 mg in 800 mg tablete.
English: The use of darunavir co-administered with low dose ritonavir and these anticoagulants is not recommended.
Slovenian: Sočasna uporaba darunavirja skupaj z majhnim odmerkom ritonavirja in navedenih antikoagulantov ni priporočljiva.
English: Amitriptyline Desipramine Imipramine Nortriptyline Trazodone paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
Slovenian: ANTIDEPRESIVI paroksetin 20 mg enkrat na dan sertralin 50 mg enkrat na dan amitriptilin dezipramin imipramin nortriptilin trazodon paroksetin AUC ↓ 39 % paroksetin Cmin ↓ 37 % paroksetin Cmax ↓ 36 % darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49 % sertralin Cmin ↓ 49 % sertralin Cmax ↓ 44 % darunavir AUC ↔ darunavir Cmin ↓ 6 % darunavir Cmax ↔
English: Therefore the same once daily dosage may be used in treatment-experienced adolescents aged 12 to < 18 years and weighing at least 40 kg without darunavir resistance associated mutations (DRV-RAMs)* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Slovenian: Zato se lahko enako enkrat dnevno odmerjanje uporabi pri mladostnikih, starih 12 do < 18 let in s telesno maso najmanj 40 kg, z izkušnjami z zdravljenjem, ki nimajo mutacij, povezanih z odpornostjo proti darunavirju (DRVRAM)*, in imajo plazemsko koncentracijo HIV-1 RNK < 100.000 kopij/ml in število celic CD4+ ≥ 100 celic x 10
English: EU/1/17/1249/009 30 film-coated tablets EU/1/17/1249/010 90 film-coated tablets
Slovenian: EU/1/17/1249/009 30 filmsko obloženih tablet EU/1/17/1249/010 90 filmsko obloženih tablet
English: Medicinal products that may be affected by darunavir boosted with cobicistat
Slovenian: Zdravila, na katera lahko vpliva darunavir, okrepljenim s kobicistatom
English: Darunavir/ritonavir 800/100 mg once daily in ART-experienced patients should not be used in patients with one or more darunavir resistance associated mutations (DRV-RAMs) or HIV-1 RNA ≥ 100,000 copies/ml or CD4+ cell count < 100 cells x 10
Slovenian: Režima darunavir/ritonavir 800/100 mg enkrat na dan pri bolnikih, ki imajo izkušnje z ART, ne smemo uporabljati pri bolnikih z eno ali več mutacijami, povezanimi z odpornostjo proti darunavirju (DRV-RAM), ali s koncentracijo HIV-1 RNK ≥ 100.000 kopij/ml ali s številom celic CD4+ < 100 celic x 10
English: Indinavir 800 mg twice daily indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ darunavir AUC ↑ 24% darunavir Cmin ↑ 44% darunavir Cmax ↑ 11% Indinavir: comparison of indinavir/ritonavir 800/100 mg twice daily
Slovenian: indinavir 800 mg dvakrat na dan indinavir AUC ↑ 23 % indinavir Cmin ↑ 125 % indinavir Cmax ↔ darunavir AUC ↑ 24 % darunavir Cmin ↑ 44 % darunavir Cmax ↑ 11 % indinavir: primerjava jemanja učinkovin indinavir/ritonavir 800/100 mg dvakrat na dan s kombinacijo indinavir/darunavir/ritonavir
English: Cobicistat and ritonavir inhibit CYP3A, thereby increasing the plasma concentrations of darunavir considerably.
Slovenian: Kobicistat in ritonavir zavirata CYP3A in tako močno zvišata plazemske koncentracije darunavirja.
English: These active substances include e.g.: alfuzosin amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine astemizole, terfenadine colchicine when used in patients with renal and/or hepatic impairment (see section 4.5) ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine) elbasvir/grazoprevir cisapride dapoxetine domperidone naloxegol lurasidone, pimozide, quetiapine, sertindole (see section 4.5) triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5) sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5).
Slovenian: - alfuzosin - amjodaron, bepridil, dronedaron, ivabradin, kinidin, ranolazin - astemizol, terfenadin - kolhicin, kadar se uporablja pri bolnikih z okvaro ledvic/jeter (glejte poglavje 4.5) - alkaloidi ergot (npr. dihidroergotamin, ergonovin, ergotamin in metilergonovin) - elbasvir/grazoprevir - cisaprid dapoksetin domperidon naloksegol - lurazidon, pimozid, kvetiapin, sertindol (glejte poglavje 4.5) - triazolam, midazolam s peroralnim odmerjanjem (za opozorila pri peroralnem odmerjanju midazolama glejte poglavje 4.5) - sildenafil - kadar se uporablja za zdravljenje pljučne arterijske hipertenzije, avanafil - simvastatin, lovastatin in lomitapid (glejte poglavje 4.5) - dabigatran, tikagrelor (glejte poglavje 4.5)
English: One dose is between 15 and 30 kilograms
Slovenian: 15 do 30 kg
English: For patients with renal or hepatic impairment colchicine with boosted darunavir is contraindicated (see sections 4.3 and 4.4).
Slovenian: Pri bolnikih z ledvično ali jetrno okvaro je kombinacija kolhicina in okrepljenega darunavirja kontraindicirana (glejte poglavji 4.3 in 4.4).
English: Dose for children 3 years of age and above, weighing more than 40 kilograms who have not taken antiretroviral medicines before (your child's doctor will determine this) The usual dose of Darunavir Krka is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka or 1 tablet containing 800 milligram of Darunavir Krka) together with 100 milligram ritonavir once daily.
Slovenian: Odmerek za otroke, stare 3 leta ali več in s telesno maso najmanj 40 kg, ki so že prejemali protiretrovirusna zdravila (to bo določil otrokov zdravnik) Odmerek je lahko: - 800mg zdravila Darunavir Krka (dve tableti zdravila Darunavir Krka po 400 mg ali ena tableta zdravila Darunavir Krka po 800 mg) skupaj s 100 mg ritonavirja enkrat na dan. ALI - 600 mg zdravila Darunavir Krka (ena tableta zdravila Darunavir Krka po 600 mg) skupaj s 100 mg ritonavirja dvakrat na dan.
English: No post weaning functions were affected with darunavir alone or in combination with ritonavir.
Slovenian: Ni bilo vpliva na funkcije po odstavitvi od dojenja ne pri dajanju samega darunavirja ne pri dajanju darunavirja v kombinaciji z ritonavirjem.
English: The effects on co-administered medicinal products may thus be underestimated and clinical monitoring o safety may be indicated.
Slovenian: Zato so lahko učinki sočasne uporabe zdravil podcenjeni in je zaradi varnosti potrebno spremljanje.
English: The recommended dose regimen is 600 mg twice daily taken with ritonavir 100 mg twice daily taken with food.
Slovenian: Priporočljivo je odmerjanje 600 mg darunavirja dvakrat na dan, skupaj s 100 mg ritonavirja dvakrat na dan, s hrano.
English: Darunavir Krka must be taken in combination with a low dose of ritonavir and other anti-HIV medicines.
Slovenian: Zdravilo Darunavir Krka je treba jemati skupaj z majhnim odmerkom ritonavirja in z drugimi zdravili proti okužbi s HIV.
English: Darunavir must always be given orally with low dose ritonavir as a pharmacokinetic enhancer and in combination with other antiretroviral medicinal products (see section 5.2).
Slovenian: Darunavir se mora vedno uporabljati peroralno z majhnim odmerkom farmakokinetičnega ojačevalca ritonavirja, in v kombinaciji z drugimi protiretrovirusnimi zdravili (glejte poglavje 5.2).
English: 30 film-coated tablets: EU/1/17/1249/009 90 film-coated tablets: EU/1/17/1249/010
Slovenian: 30 filmsko obloženih tablet: EU/1/17/1249/009 90 filmsko obloženih tablet: EU/1/17/1249/010
English: For patients with renal or hepatic impairment colchicine with darunavir co-administered with low dose ritonavir is contraindicated (see sections 4.3 and 4.4).
Slovenian: Pri bolnikih z ledvično ali jetrno okvaro je kombinacija kolhicina in darunavirja skupaj z majhnim odmerkom ritonavirja kontraindicirana (glejte poglavje 4.3 in 4.4).
English: No dose adjustment for darunavir /ritonavir is recommended.
Slovenian: Prilagajanje odmerkov zdravil darunavir/ritonavir ni priporočljivo.
English: If parenteral midazolam is co-administered with boosted darunavir it may cause a large increase in the concentration of this benzodiazepine.
Slovenian: Sočasna uporaba parenteralnega midazolama in okrepljenega darunavirja lahko povzroči veliko zvišanje koncentracije tega benzodiazepina.
English: If there is evidence of new or worsening liver dysfunction (including clinically significant elevation of liver enzymes and/or symptoms such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) in patients using darunavir used in combination with cobicistat or low dose ritonavir, interruption or discontinuation of treatment should be considered promptly.
Slovenian: Če pri bolnikih, ki se zdravijo z darunavirjem v kombinaciji s kobicistatom ali z majhnim odmerkom ritonavirja, opazite znake o novih ali o poslabšanju obstoječih motenj v delovanju jeter (vključno s klinično pomembnim zvišanjem koncentracije jetrnih encimov in/ali simptomi kot so utrujenost, anoreksija, navzea, zlatenica, temen urin, boleča jetra, hepatomegalija), je nemudoma treba razmisliti o prekinitvi ali ukinitvi zdravljenja.
English: The effects of high fluticasone systemic exposure on ritonavir plasma levels are
Slovenian: Učinek visoke sistemske izpostavljenosti flutikazonu na plazemske koncentracije ritonavirja ni znan.
English: Gastrointestinal disorders very common diarrhoea common vomiting, nausea, abdominal pain, increased blood amylase, dyspepsia, abdominal distension, flatulence uncommon pancreatitis, gastritis, gastrooesophageal reflux disease, aphthous stomatitis, retching, dry mouth, abdominal discomfort, constipation, increased lipase, eructation, oral dysaesthesia rare stomatitis, haematemesis, cheilitis, dry lip, coated tongue
Slovenian: Bolezni prebavil zelo pogosti driska pogosti bruhanje, navzea, bolečina v trebuhu, povišanje amilaze v krvi, dispepsija, napihnjen trebuh, flatulenca občasni pankreatitis, gastritis, gastroezofagealna refluksna bolezen, aftozni stomatitis, siljenje na bruhanje, suha usta, napetost v trebuhu, zaprtje, povišane lipaze, spahovanje, disestezija v ustih redki stomatitis, hematemeza, heilitis, suhe ustnice, obložen jezik
English: 100 milligram ritonavir oral solution: 80 milligram per milliliter
Slovenian: 100 mg peroralna raztopina ritonavirja: 80 mg/ml
English: ANTICONVULSANTS Phenobarbital Phenytoin
Slovenian: ANTIEPILEPTIKI fenobarbital fenitoin
English: Etravirine 100 mg twice daily etravirine AUC ↓ 37% etravirine Cmin ↓ 49% etravirine Cmax ↓ 32% darunavir AUC ↑ 15% darunavir Cmin ↔ darunavir Cmax ↔
Slovenian: etravirin 100 mg dvakrat na dan etravirin AUC ↓ 37 % etravirin Cmin ↓ 49 % etravirin Cmax ↓ 32 % darunavir AUC ↑ 15 % darunavir Cmin ↔ darunavir Cmax ↔
English: Concomitant use of everolimus and boosted darunavir is not recommended.
Slovenian: Sočasna uporaba everolimusa in okrepljenega darunavirja ni priporočljiva.
English: Efavirenz in combination with boosted darunavir once daily may result in sub-optimal darunavir Cmin.
Slovenian: Pri uporabi kombinacije efavirenz in okrepljenega zdravila darunavir enkrat na dan se Cmin darunavirja lahko zniža pod optimalno vrednost.
English: ANTIGOUT MEDICINES Colchicine
Slovenian: ZDRAVILA ZA ZDRAVLJENJE PROTINA kolhicin
English: In women receiving darunavir/ritonavir 600/100 mg twice daily during the second trimester of pregnancy, mean intra-individual values for total darunavir Cmax, AUC12h and Cmin were 28%, 26% and 26% lower, respectively, as compared with postpartum; during the third trimester of pregnancy, total darunavir Cmax, AUC12h and Cmin values were 18%, 16% lower and 2% higher, respectively, as compared with postpartum.
Slovenian: Pri ženskah, ki so med drugim trimesečjem nosečnosti prejemale zdravili darunavir/ritonavir v odmerkih 600/100 mg dvakrat na dan, so bile med posameznicami povprečne vrednosti celokupnega darunavirja Cmax, AUC12h in Cmin za 28 %, 26 % oziroma 26 % manjše kot v obdobju po porodu.
English: Human experience of acute overdose with darunavir co-administered with cobicistat or low dose ritonavir is limited.
Slovenian: Izkušnje z akutnim prevelikim odmerjanjem darunavirja skupaj s kobicistatom ali z majhnim odmerkom ritonavirja pri ljudeh so omejene.
English: Third Trimester of pregnancy (n=15)
Slovenian: Tretje trimesečje nosečnosti (n = 15)
English: Lopinavir/ritonavir 400/100 mg twice daily + OBR N=297
Slovenian: lopinavir/ritonavir 400/100 mg dvakrat na dan +OBR n = 297
English: Darunavir Krka with ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Slovenian: Zdravilo Darunavir Krka z ritonavirjem ni bilo preskušano v kombinaciji z vsemi zaviralci proteaz in se ne sme uporabljati skupaj z drugimi zaviralci proteaz HIV.
English: Co-administration of darunavir and ritonavir and other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (e.g. indinavir, azole antifungals like clotrimazole).
Slovenian: Sočasna uporaba darunavirja in ritonavirja z zdravili, ki zavirajo encim CYP3A, lahko zmanjša očistek darunavirja in ritonavirja in posledično zviša plazemske koncentracije darunavirja in ritonavirja (npr. indinavir, protiglivični azoli, kot je klotrimazol).
English: ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindrone AUC ↓ 14% norethindrone Cmin ↓ 30% norethindrone Cmax ↔ with darunavir/ritonavir
Slovenian: s kombinacijo darunavir/kobicistat etinilestradiol AUC ↓ 44 % etinilestradiol Cmin ↓ 62 % etinilestradiol Cmax ↓ 32 % noretindron AUC ↓ 14 % noretindron Cmin ↓ 30 % noretindron Cmax ↔
English: Nicardipine Nifedipine Verapamil blockers.
Slovenian: ZAVIRALCI KALCIJEVIH KANALČKOV amlodipin diltiazem felodipin nikardipin nifedipin verapamil