FrancophonIA/ELRC3.0 huggingface dataset:
English: Important information regarding medicinal product interactions when ritonavir is used as a pharmacokinetic enhancer is also contained in the Summary of Product Characteristics of the co-administered protease inhibitor.
Danish: Vigtig information vedrørende lægemiddelinteraktioner, når ritonavir anvendes som farmakokinetisk forstærker findes også i produktresuméerne for den samtidigt administrerede proteasehæmmer.
English: Since the renal clearance of ritonavir is negligible, the decrease in the total body clearance is not expected in patients with renal impairment (see also section 4.2).
Danish: Eftersom ritonavirs renale clearance er minimal, forventes der ikke noget fald i den totale clearance hos patienter med nedsat nyrefunktion (se også pkt.
English: Ritonavir doses higher than 100 mg twice daily have not been studied with darunavir.
Danish: Der er ikke udført studier med højere doser af ritonavir end 100 mg to gange dagligt sammen med darunavir.
English: Clinical trials confirmed the safety and efficacy of fosamprenavir 700 mg twice daily with ritonavir 100 mg twice daily.
Danish: Kliniske studier har bekræftet sikkerheden og virkningen ved 700 mg fosamprenavir to gange dagligt med 100 mg ritonavir to gange dagligt.
English: For further information, physicians should refer to the Summary of Product Characteristics for tipranavir.
Danish: For yderligere oplysninger henvises læger til produktresuméet for tipranavir.
English: 300 q24 h
Danish: 300 mg hver 24. time
English: In a clinical study investigating the interaction of rifampicin 600 mg once daily and saquinavir 1,000 mg with ritonavir 100 mg twice daily in healthy volunteers, severe hepatocellular toxicity with transaminase elevations up to > 20-fold the upper limit of normal after 1 to 5 days of co-administration was noted.
Danish: I studier blev der set alvorlig hepatocellulær tocixitet med forhøjede amonitransferaser på op til > 20-gange den øvre normale grænse efter 1 til 5 dages samtidig administration.
English: Lopinavir co-formulated with ritonavir (lopinavir/ritonavir) 400 mg/100 mg or 800 mg/200 mg. Saquinavir 1,000 mg twice daily with ritonavir 100 mg twice daily in ART experienced patients.
Danish: Lopinavir formuleret sammen med ritonavir (lopinavir/ritonavir) 400 mg/100 mg eller 800 mg/200 mg.
English: Bedaquiline
Danish: Bedaquilin
English: Monitor for ADRs related to afatinib.
Danish: Der skal monitoreres for afatinib-relaterede bivirkninger.
English: However, since the renal clearance of ritonavir is negligible, the decrease in the total body clearance is not expected in patients with renal impairment.
Danish: Eftersom den renale clearance af ritonavir er minimal, forventes der dog ikke noget fald i kroppens samlede clearance hos patienter med nedsat nyrefunktion.
English: 600 q12 h 2 h later
Danish: 600 mg hver 12. time 2 t senere
English: • diabetes
Danish: Diabetes mellitus
English: Serum concentrations may be increased due to CYP3A inhibition by ritonavir, resulting in increased risk of tumour lysis syndrome at the dose initiation and during the ramp-up phase (see section 4.3 and refer to the venetoclax SmPC).
Danish: Serumkoncentrationen kan øges på grund af ritonavirs hæmning af CYP3A, hvilket kan medføre en øget risiko for tumorlysesyndrom ved dosisinitiering og i titreringsfasen (se pkt.
English: Particular caution should be used when prescribing ritonavir in patients using trazodone.
Danish: Ordination af ritonavir til patienter, der er i behandling med trazodon, bør ske med særlig forsigtighed.
English: Do not take a double dose to make up for a forgotten dose.
Danish: Hvis det er lige før, du skulle have taget den næste dosis, skal du kun tage den. Du må ikke tage en dobbeltdosis som erstatning for den glemte dosis.
English: Herbal preparations containing St John's wort must not be used in combination with ritonavir.
Danish: Naturlægemidler, som indeholder perikon, må derfor ikke anvendes i kombination med ritonavir.
English: Alpha1-Adrenoreceptor antagonist Alfuzosin
Danish: 1-adrenerge antagonister
English: Ritonavir doses higher than 100 mg twice daily have not been studied with fosamprenavir.
Danish: Der er ikke udført studier med højere doser af ritonavir end 100 mg to gange dagligt sammen med fosamprenavir.
English: More frequent electrocardiogram monitoring and monitoring of transaminases is recommended (see section 4.5 and refer to the bedaquiline Summary of Product Characteristics).
Danish: Hyppigere monitorering af elektrokardiogram og monitorering af transaminaser anbefales (se pkt.
English: Thereby, increasing the risk of serious arrhythmias from these agents.
Danish: Derved øges risikoen for alvorlige arytmier forårsaget af disse midler.
English: Ritonavir must not be given to patients with severe hepatic impairment (see section 4.3).
Danish: Ritonavir må ikke gives til patienter med alvorligt nedsat leverfunktion (se pkt.
English: 150 daily
Danish: 150 mg dagligt
English: Fosamprenavir 700 mg twice daily with ritonavir 100 mg twice daily.
Danish: 700 mg fosamprenavir to gange dagligt med 100 mg ritonavir to gange dagligt.
English: Therefore, ritonavir should not be co-administered with orally administered midazolam (see section 4.3), whereas caution should be used with co-administration of ritonavir and parenteral midazolam.
Danish: Ritonavir bør derfor ikke administreres samtidig med oralt administreret midazolam (se pkt.
English: Due to CYP3A inhibition by ritonavir, concentrations of lurasidone are expected to increase.
Danish: På grund af ritonavirs CYP3A-hæmning forventes koncentrationen af lurasidon at stige.
English: STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 100 mg of ritonavir.
Danish: ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver filmovertrukket tablet indeholder 100 mg ritonavir.
English: 200 q12 h, 2 days
Danish: 500 mg hver 12. time, 2 dage
English: When ritonavir is used as a pharmacokinetic enhancer with other protease inhibitors the Summary of Product Characteristics for the particular protease inhibitor must be consulted.
Danish: Når ritonavir anvendes som en farmakokinetisk forstærker af andre proteasehæmmere, skal produktresuméet for den samtidigt indgivne proteasehæmmer konsulteres med hensyn til kontraindikationer.
English: Amprenavir 600 mg twice daily with ritonavir 100 mg twice daily.
Danish: 600 mg amprenavir to gange dagligt med 100 mg ritonavir to gange dagligt.
English: Serum concentrations may be increased due to CYP3A and P-gp inhibition by ritonavir.
Danish: Serumkoncentrationen kan øges på grund af ritonavirs hæmning af CYP3A og P-gp.
English: Careful monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with antiretroviral doses of ritonavir (see section 4.4).
Danish: Nøje overvågning af terapeutiske virkninger og bivirkninger anbefales, når disse lægemidler indgives sammen med antiretrovirale doser af ritonavir (se pkt.
English: 200 qd
Danish: 20 mg
English: 200 q12 h Tipranavir Ritonavir
Danish: Tipranavir ↑ 11 gange ↑ 29 gange Ritonavir
English: Ritonavir medicinal product level decreased Herbal preparation
Danish: Formindsket koncentration af ritonavir Naturlægemidler
English: When ritonavir is used as a pharmacokinetic enhancer with other PIs, full details on the warnings and precautions relevant to that particular PI should be considered, therefore the Summary of Product Characteristics for the particular PI must be consulted.
Danish: Når ritonavir anvendes som en farmakokinetisk forstærker med andre proteasehæmmere, bør de fuldstændige oplysninger vedrørende advarsler og forsigtighedsregler, der gælder for netop den proteasehæmmer, tages i betragtning, og derfor skal produktresuméet for den konkrete proteasehæmmer konsulteres.
English: Due to CYP3A inhibition by ritonavir, concentrations of ranolazine are expected to increase.
Danish: På grund af ritonavirs CYP3A-hæmning forventes koncentrationen af ranolazin at stige.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of cyclosporine, tacrolimus or everolimus.
Danish: Ritonavir doseret som farmakokinetisk forstærker eller som antiretroviralt lægemiddel hæmmer CYP3A4 og forventes som følge heraf at øge plasmakoncentrationerne af ciclosporin, tacrolimus eller everolimus.
English: 500 q12 h
Danish: 500 mg hver 12. time
English: 1,000 q12 h
Danish: 1.000 mg hver 12. time
English: Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Danish: Ætiologien anses dog for at være multifaktoriel (omfattende anvendelse af kortikosteroider, alkoholforbrug, svær immunosuppression, højere Body Mass Index (BMI)).
English: ↑ 14 fold
Danish: Darunavir ↑ 14 gange
English: Pancreatitis
Danish: Pankreatit
English: 200 mg once daily
Danish: 200 mg en gang dagligt
English: Levothyroxine
Danish: Osteonekrose
English: The co-administration of riociguat with ritonavir is not recommended (see section 4.4 and refer to riociguat SmPC).
Danish: Samtidig administration af riociguat og ritonavir anbefales ikke (se pkt.
English: When ritonavir is used as a pharmacokinetic enhancer at the 100 mg and 200 mg level it cannot be assumed that the following warnings and precautions will also apply.
Danish: Det kan ikke forudsættes, at følgende advarsler og forsigtighedsregler også gælder, når ritonavir anvendes som en farmakokinetisk forstærker ved niveauet 100 mg og 200 mg.
English: Careful monitoring of serum levels or therapeutic effects is recommended when these medicines are concomitantly administered with ritonavir.
Danish: Nøje overvågning af serumniveau og terapeutiske virkning anbefales, når disse lægemidler indgives sammen med ritonavir.
English: Arthralgia and back pain Myositis, rhabdomyolysis, myalgia, myopathy/CPK increased
Danish: Meget almindelig Artralgi og rygsmerter Ikke almindelig Myosit, rabdomyolyse, myalgi, myopati/forhøjet kreatinase
English: 100q12h ↓ 39% ↓ 24% Concomitant use of ritonavir dosed as an antiretroviral agent and voriconazole is contraindicated due to reduction in voriconazole concentrations (see section 4.3).
Danish: Samtidig anvendelse af ritonavir doseret som antiretroviralt lægemiddel og voriconazol er kontraindiceret på grund af reducerede voriconazolkoncentration (se pkt.
English: Increased neutrophils
Danish: Ikke almindelig Forhøjet antal neutrofile celler
English: 400 q12 h Saquinavir4 Ritonavir
Danish: Saquinavir4 ↑ 15 gange ↑ 5 gange Ritonavir
English: 50 μg, single dose
Danish: 50 mg, enkeltdosis
English: Please also review the Summary of Product Characteristics for the particular boosted PI.
Danish: Se også produktresuméet for den konkrete boostede proteasehæmmer.
English: How to take Ritonavir Mylan
Danish: Sådan skal du tage Ritonavir Mylan
English: 100 mg twice daily1
Danish: 100 mg to gange dagligt1
English: Careful monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with antiretroviral doses of ritonavir.
Danish: Nøje overvågning af den terapeutiske virkning og bivirkninger anbefales, når disse lægemidler indgives sammen med ritonavir ved antiretrovirale doser.
English: PDE5 inhibitor
Danish: PDE5-hæmmere
English: Increased plasma concentrations of avanafil (see sections 4.4. and 4.5).
Danish: Forhøjede plasmakoncentrationer af avanafil (se pkt.
English: Careful monitoring of therapeutic and adverse effects is recommended when dexamethasone is concomitantly administered with ritonavir.
Danish: Nøje overvågning af den terapeutiske virkning og bivirkninger anbefales, når dexamethason indgives sammen med ritonavir.
English: Ritonavir co-administration is likely to result in increased plasma concentrations of both fusidic acid and ritonavir and is therefore contraindicated (see section 4.3).
Danish: Samtidig administration af ritonavir vil sandsynligvis resultere i øget plasmakoncentration af både fusidinsyre og af ritonavir og er derfor kontraindiceret (se pkt.
English: Ritonavir increases the serum levels of maraviroc as a result of CYP3A inhibition.
Danish: Ritonavir øger serumniveauerne af maraviroc som resultat af CYP3A-hæmning.
English: Desipramine
Danish: Desipramin
English: Ritonavir increases the serum levels of amprenavir (from fosamprenavir) as a result of CYP3A4 inhibition.
Danish: Ritonavir øger serumniveauerne af amprenavir (fra fosamprenavir) som resultat af CYP3A4hæmning.
English: 800 q12 h
Danish: 800 mg hver 12. time
English: Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines, including medicines obtained without a prescription.
Danish: Brug af anden medicin sammen med Ritonavir Mylan Fortæl altid lægen eller apotekspersonalet, hvis du bruger anden medicin eller har gjort det for nylig, herunder lægemidler uden recept.
English: For further information, physicians should refer to the Summary of Product Characteristics for fosamprenavir.
Danish: For yderligere oplysninger henvises læger til produktresuméet for fosamprenavir.
English: Co-administration of atazanavir with ritonavir at doses greater than 100 mg once daily has not been clinically evaluated.
Danish: Der er ikke foretaget en klinisk vurdering af samtidig administration af atazanavir og ritonavir ved højere doser end 100 mg en gang dagligt.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reconstitution; however, the reported time to onset is more variable and can occur many months after initiation of treatment.
Danish: Det er også rapporteret, at autoimmune sygdomme (f.eks. Graves sygdom og autoimmun hepatitis) kan forekomme i tilfælde af immunreaktivering.
English: For further information, physicians should refer to the Summary of Product Characteristics for amprenavir.
Danish: For yderligere oplysninger henvises læger til produktresuméet for amprenavir.
English: What Ritonavir Mylan is and what it is used for What you need to know before you or your child takes Ritonavir Mylan How to take Ritonavir Mylan
Danish: Det skal du vide, før du eller dit barn begynder at tage Ritonavir Mylan Sådan skal du tage Ritonavir Mylan Bivirkninger
English: 100q12h Raltegravir
Danish: Raltegravir 400 mg enkeltdosis
English: Ritonavir co-administration is likely to result in increased plasma concentrations of astemizole and terfenadine and is therefore contraindicated (see section 4.3).
Danish: Samtidig administration af ritonavir vil sandsynligvis resultere i forhøjet plasmakoncentration af astemizol og terfenadin og er derfor kontraindiceret (se pkt.
English: Ritonavir increases the serum levels of darunavir as a result of CYP3A inhibition.
Danish: Ritonavir øger serumniveauerne af darunavir som resultat af CYP3A-hæmning.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of erythromycin and itraconazole.
Danish: Ritonavir doseret som farmakokinetisk forstærker eller antiretroviralt lægemiddel hæmmer CYP3A4 og forventes som følge heraf at øge plasmakoncentrationerne af erythromycin og itraconazol.
English: 4.4 Special warnings and precautions for use Ritonavir is not a cure for HIV-1 infection or AIDS.
Danish: Ritonavir helbreder hverken hiv-1-infektion eller AIDS.
English: For specific information regarding the impact of co-administration of acid reducing agents, refer to the Summary of Product Characteristics of the co-administered protease inhibitor.
Danish: For særlig information vedrørende virkningen af samtidig administration af syrehæmmende midler, se produktresuméet for proteasehæmmeren, som administreres samtidig.
English: More frequent electrocardiogram monitoring and monitoring of transaminases is recommended (see section 4.4 and refer to the bedaquiline Summary of Product Characteristics).
Danish: Hyppigere monitorering af elektrokardiogram og monitorering af aminotransferaser anbefales (se pkt.
English: Clinical pharmacodynamic data
Danish: Farmakodynamisk virkning
English: The co-administration of vorapaxar with ritonavir is not recommended (see section 4.4 and refer to the vorapaxar SmPC).
Danish: Samtidig administration af vorapaxar og ritonavir anbefales ikke (se pkt.
English: Careful monitoring of therapeutic and adverse effects is recommended when loratadine is concomitantly administered with ritonavir.
Danish: Nøje overvågning af terapeutisk virkning og bivirkninger anbefales, når loratadin indgives sammen med ritonavir.
English: Due to the risk of bedaquiline related adverse events, co-administration should be avoided.
Danish: Samtidig administration bør undgås på grund af risikoen for bedaquilin-relaterede bivirkninger.
English: 13 days
Danish: 12. time
English: 200 q12 h/1 h before
Danish: time/1time før
English: 50, oral single dose
Danish: 50 mg, enkeltdosis oral
English: In a healthy volunteer drug interaction study of delamanid 100 mg twice daily and lopinavir/ritonavir 400/100 mg twice daily for 14 days, the
Danish: I et interaktionsstudie med raske forsøgspersoner, der fik 100 mg delamanid to gange dagligt og lopinavir/ritonavir 400/100 mg to gange dagligt i 14 dage, var eksponeringen af delamanid-metabolitten DM-6705 øget med 30 %.
English: The dose of ritonavir may need adjusting.
Danish: Ritonavir-koncentrationen kan øges ved seponering af perikon, og det kan være nødvendigt at justere ritonavirdosis.
English: 400 q12 h
Danish: 400 mg hver 12. time
English: 100q12h Maraviroc
Danish: Maraviroc 100 mg hver 12. time
English: Ritonavir dosed as an antiretroviral agent is likely to inhibit CYP2D6 and as a result is expected to increase concentrations of haloperidol, risperidone and thioridazine.
Danish: Haloperidol, risperidon, thioridazin Det er sandsynligt, at ritonavir doseret som antiretroviralt lægemiddel hæmmer CYP2D6 og forventes som følge heraf at øge plasmakoncentrationerne af haloperidol, risperidon og thioridazin.
English: Ritonavir co-administration is likely to result in increased plasma concentrations of cisapride and is therefore contraindicated (see section 4.3).
Danish: Samtidig administration af ritonavir vil sandsynligvis resultere i forhøjet plasmakoncentration af cisaprid og er derfor kontraindiceret (se pkt.
English: 500q12h ↑ 3.4-fold ↑ 55% Ritonavir inhibits CYP3A-mediated metabolism of ketoconazole.
Danish: Ritonavir hæmmer den CYP3A-medierede metabolisering af ketoconazol.
English: Due to CYP3A inhibition by ritonavir, concentrations of lomitapide are expected to increase.
Danish: Da ritonavir inhiberer CYP3A, forventes koncentrationer af lomitapid at stige.
English: 100 q12 h Indinavir3 Ritonavir
Danish: Indinavir3 ↑ 178 % ND Ritonavir
English: Hormonal contraceptive Ethinylestradiol
Danish: Hormonale kontraceptiva
English: 400 q8 h
Danish: 3 mg/kg hver 8. time
English: Ritonavir dosed as a pharmacokinetic enhancer The interaction profiles of HIV-protease inhibitors, co-administered with low dose ritonavir, are dependent on the specific co-administered protease inhibitor.
Danish: Interaktionsprofilen for hiv-proteasehæmmere ved samtidig administration af lave doser af ritonavir afhænger af den pågældende samtidigt indgivne proteasehæmmer.
English: Ritonavir co-administration is likely to result in increased plasma concentrations of clozapine or pimozide and is therefore contraindicated (see section 4.3).
Danish: Samtidig administration af ritonavir vil sandsynligvis resultere i forhøjede plasmakoncentrationer af clozapin eller pimozid og er derfor kontraindiceret (se pkt.
English: Due to CYP3A inhibition by ritonavir, concentrations of quetiapine are expected to increase.
Danish: På grund af lopinavir/ritonavirs hæmning af CYP3A forventes koncentrationen af quetiapin at stige.
English: Increased plasma concentrations of vardenafil (see sections 4.4. and 4.5).
Danish: Forhøjede plasmakoncentrationer af vardenafil (se pkt.
English: 600 q12 h
Danish: 600 hver 12. time
English: Careful monitoring of therapeutic and adverse effects is recommended when buspirone concomitantly administered with ritonavir.
Danish: Nøje overvågning af den terapeutiske virkning og bivirkninger anbefales, når buspiron indgives sammen med ritonavir.
English: SN NN
Danish: PC SN NN
English: Ritonavir co-administration is likely to result in increased plasma concentrations of alfuzosin and is therefore contraindicated (see section 4.3).
Danish: Samtidig administration af Ritonavir vil sandsynligvis resultere i forhøjet plasmakoncentration af alfuzosin og er derfor kontraindiceret (se pkt.
English: Antimycobacterial
Danish: Antimykotika
English: HDPE bottle with polypropylene screw cap with inbuilt desiccant.
Danish: 6.5 Emballagetype og pakningsstørrelser HDPE-beholder med skruelåg af polypropylen og med indlagt tørremiddel.
English: • serious allergic reaction (anaphylaxis) • high levels of sugar in the blood
Danish: • højt indhold af sukker i blodet
English: Careful monitoring of therapeutic and adverse effects is recommended when carbamazepine is concomitantly administered with ritonavir.
Danish: Nøje overvågning af den terapeutiske virkning og bivirkninger anbefales, når carbamazepin indgives sammen med ritonavir
English: Pharyngitis, oropharyngeal pain, cough
Danish: Meget almindelig Faryngitis, orofaryngeal smerte, hoste
English: Ritonavir increases the serum levels of atazanavir as a result of CYP3A4 inhibition.
Danish: Ritonavir øger serumniveauerne af atazanavir som resultat af CYP3A4-hæmning.
English: For specific dosing information in patients with renal impairment, refer to the Summary of Product Characteristics (SPC) of the co-administered protease inhibitor.
Danish: For konkrete oplysninger om dosering til patienter med nedsat nyrefunktion henvises til produktresuméet for den proteasehæmmer, der gives sammen med ritonavir.
English: ↑ 2 fold
Danish: Se pkt.
English: 200 q12 h/6 h after
Danish: time/6 timer efter
English: Serum concentrations may be increased due to CYP3A4 inhibition by ritonavir.
Danish: Serumkoncentrationer kan øges, da ritonavir inhiberer CYP3A4.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A and as a result is expected to increase the plasma concentrations of dexamethasone.
Danish: Ritonavir doseret som farmakokinetisk forstærker eller som antiretroviralt lægemiddel hæmmer CYP3A og forventes som følge heraf at øge plasmakoncentrationerne af dexamethason.
English: Careful monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with ritonavir.
Danish: Nøje overvågning af den terapeutiske virkning og bivirkninger anbefales, når disse lægemidler indgives sammen med ritonavir.
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of fentanyl.
Danish: Ritonavir doseret som farmakokinetisk forstærker eller som antiretroviralt lægemiddel hæmmer CYP3A4 og forventes som følge heraf at øge plasmakoncentrationerne af fentanyl.
English: Darunavir 600 mg twice daily with ritonavir 100 mg twice daily in antiretroviral treatment.
Danish: Darunavir 600 mg to gange dagligt med ritonavir 100 mg to gange dagligt til patienter, der tidligere har været i antiretroviral behandling (ART-erfarne patienter).
English: 600q12h ↓ 66% ↓ 62% Bupropion is primarily metabolised by CYP2B6.
Danish: Bupropion metaboliseres hovedsagelig af CYP2B6.
English: ↔ ↑ 4 fold
Danish: ↑ 3,4 gange
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of carbamazepine.
Danish: Ritonavir doseret som en farmakokinetisk forstærker eller som antiretroviralt lægemiddel hæmmer CYP3A4 og forventes som følge heraf at øge plasmakoncentrationerne af carbamazepin.
English: Ritonavir increases the serum levels of saquinavir as a result of CYP3A4 inhibition.
Danish: Ritonavir øger serumniveauerne af saquinavir som resultat af CYP3A4- hæmning.