FrancophonIA/ELRC3.0 huggingface dataset:
English: How much to take
Slovenian: Koliko zdavila je potrebno vzeti
English: • Swallow the tablet whole with a half glass of water.
Slovenian: • Tableto pogoltnite celo, s pol kozarca vode.
English: ATC code: A10BX11.
Slovenian: Oznaka ATC: A10BX11.
English: However, if it is nearly time for the next dose, skip the missed dose.
Slovenian: Če pa je že skoraj čas za naslednji odmerek, izpustite pozabljeni odmerek.
English: It is best to take your tablet before the first meal of the day.
Slovenian: Najbolje je če tableto vzamete pred prvim dnevnim obrokom.
English: Your doctor will decide whether to increase your dose to 300 mg.
Slovenian: Zdravnik se bo odločil, ali bo odmerek povečal na 300 mg.
English: These reductions were sustained over the treatment period and near maximal after the first day of treatment.
Slovenian: Navedena znižanja so se ohranila v celotnem obdobju zdravljenja in so dosegala skoraj največji obseg po prvem dnevu zdravljenja.
English: In general, elevations were transient and did not require specific treatment.
Slovenian: Zvišanja so bila večinoma prehodna, specifično zdravljenje ni bilo potrebno.
English: In particular, tell your doctor if you are taking any of the following medicines:
Slovenian: Zdravnika obvestite zlasti, če jemljete katero od naslednjih zdravil:
English: • You can take your tablet with or without food.
Slovenian: • Zdravilo lahko vzamete s hrano ali brez nje.
English: • Your doctor will prescribe the strength that is right for you.
Slovenian: • Zdravnik vam bo predpisal odmerek, ki je za vas primeren.
English: 16% of patients were Hispanic.
Slovenian: Šestnajst odstotkov (16%) bolnikov je bilo Špancev.
English: The doctor may decide to temporarily or permanently stop the treatment with Invokana.
Slovenian: Zdravnik vam lahko začasno ali trajno ukine zdravljenje z zdravilom Invokana.
English: • Do not take a double dose (two doses on the same day) to make up for a forgotten dose.
Slovenian: • Ne vzemite dvojnega odmerka (dveh odmerkov na isti dan), če ste pozabili vzeti prejšnji odmerek.
English: Active-controlled studies
Slovenian: Aktivno nadzorovane študije
English: • Risk Management Plan (RMP)
Slovenian: ZDRAVILA • Načrt za obvladovanje tveganja (RMP)
English: Hörgatúni 2
Slovenian: Hörgatún 2
English: Lactose intolerance
Slovenian: Laktozna intoleranca
English: Do not stop taking this medicine without talking to your doctor first.
Slovenian: Ne prenehajte jemati tega zdravila, ne da bi se prej posvetovali s svojim zdravnikom.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 15 November 2013
Slovenian: Datum prve pridobitve dovoljenja za promet: 15. 11. 2013
English: Frequency categories are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Slovenian: Kategorije pogostnosti so opredeljene po naslednjem dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: 6.6 Special precautions for disposal No special requirements.
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje Ni posebnih zahtev.
English: In both cases, treatment with canagliflozin may be restarted once the patient's condition has stabilised.
Slovenian: V obeh primerih se lahko zdravljenje s kanagliflozinom ponovno uvede, ko je stanje bolnikov stabilizirano.
English: Approximately 58% of patients were male.
Slovenian: Približno 58% bolnikov je bilo moškega spola.
English: Both UGT1A9 and UGT2B4 are subject to genetic polymorphism.
Slovenian: UGT1A9 in UGT2B4 sta podvržena genetskemu polimorfizmu.
English: Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should.
Slovenian: Sladkorna bolezen tipa 2 je bolezen, pri kateri vaše telo ne tvori dovolj insulina oziroma insulin, ki ga tvori vaše telo, ne deluje tako dobro, kot bi moral.
English: More information is given below in “Other medicines and Invokana”.
Slovenian: Več podatkov lahko najdete spodaj pod naslovom “Druga zdravila in zdravilo Invokanaˮ.
English: • severe allergic reaction (may include swelling of the face, lips, mouth, tongue, or throat that may lead to difficulty breathing or swallowing).
Slovenian: • hude alergijske reakcije (lahko vključujejo otekanje obraza, ustnic, ust, jezika, grla, zaradi česar je lahko oteženo dihanje ali požiranje).
English: Tablets should be swallowed whole.
Slovenian: Tablete je treba pogoltniti cele.
English: These differences are not considered to be clinically meaningful.
Slovenian: Navedene razlike ne veljajo za klinično pomembne.
English: Elderly (≥ 65 years old)
Slovenian: Starostniki (≥ 65 let)
English: This was accompanied by a sustained reduction in serum uric acid concentration of approximately 20%.
Slovenian: To je spremljalo vztrajno znižanje koncentracije sečne kisline v serumu za približno 20%.
English: Possible signs of losing too much fluid from your body are listed at the top of section 4 “Possible side effects”.
Slovenian: Znaki morebitnega prevelikega izločanja vode iz telesa so našteti na začetku poglavja 4 “Možni neželeni učinki”.
English: The safety and efficacy of canagliflozin in children under 18 years of age have not yet been established.
Slovenian: Varnost in učinkovitost kanagliflozina pri otrocih, mlajših od 18 let, še nista bili dokazani.
English: Invokana should be taken orally once a day, preferably before the first meal of the day.
Slovenian: Zdravilo Invokana je treba jemati peroralno enkrat na dan, najbolje pred prvim dnevnim obrokom.
English: Talk to your doctor about whether to stop taking this medicine or to stop breast-feeding.
Slovenian: Z zdravnikom se pogovorite o prenehanju jemanja tega zdravila ali o prenehanju dojenja.
English: Canagliflozin is extensively bound to proteins in plasma (99%), mainly to albumin.
Slovenian: Kanagliflozin se v veliki meri veže na beljakovine v plazmi (v 99%), večinoma na albumine.
English: If interrupted, consideration should be given to more frequent glucose monitoring.
Slovenian: V primeru prekinitve zdravljenja je treba razmisliti o bolj pogostem spremljanju glikemije.
English: • if you have severe liver problems
Slovenian: • če imate hude težave z jetri
English: 58% of patients had a body mass index (BMI) ≥ 30 kg/m2.
Slovenian: 58% bolnikov je imelo indeks telesne mase (ITM) ≥ 30 kg/m2.
English: • loss of too much fluid from your body (dehydration).
Slovenian: • prevelika izguba telesnih tekočin (dehidracija).
English: SGLT2 inhibitors should be used with caution in these patients.
Slovenian: Pri teh bolnikih je treba uporabljati zaviralce SGLT2 previdno.
English: Other medicines and Invokana
Slovenian: Druga zdravila in zdravilo Invokana
English: ** See section 4.4.
Slovenian: ** glejte poglavje 4.4.
English: Invokana should not be used for the treatment of diabetic ketoacidosis as it is not effective in this setting.
Slovenian: Zdravila Invokana ne smete uporabljati za zdravljenje diabetične ketoacidoze, saj pri tem ni učinkovito.
English: • The starting dose of Invokana is one 100 mg tablet each day.
Slovenian: • Začetni odmerek zdravila Invokana je ena 100 mg tableta na dan.
English: Your doctor will tell you how to treat low blood sugar levels and what to do if you have any of the signs above.
Slovenian: Zdravnik vam bo povedal, kako ravnati v primeru znižane koncentracije sladkorja v krvi in kaj morate storiti, če se pojavijo našteti znaki.
English: The mean absolute oral bioavailability of canagliflozin is approximately 65%.
Slovenian: Povprečna absolutna peroralna biološka uporabnost kanagliflozina je približno 65%.
English: Subsequently, the marketing authorisation holder shall submit periodic safety update reports for this product in accordance with the requirements set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal.
Slovenian: Zatem jih mora predložiti v skladu z zahtevami, določenimi v seznamu referenčnih datumov Unije (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES in objavljenem na evropskem spletnem portalu o zdravilih.
English: Children and adolescents Invokana is not recommended for children and adolescents under 18 years.
Slovenian: Pri otrocih in mladostnikih, ki so stari manj kot 18 let, uporaba zdravila Invokana ni priporočena.
English: Patients taking digoxin or other cardiac glycosides (e.g., digitoxin) should be monitored appropriately.
Slovenian: Bolnike, ki jemljejo digoksin ali druge kardiotonične glikozide (na primer digitoksin), je treba ustrezno spremljati.
English: If a dose is missed, it should be taken as soon as the patient remembers; however, a double dose should not be taken on the same day.
Slovenian: Če bolnik izpusti odmerek, naj ga vzame takoj, ko se spomni, vendar na isti dan ne sme vzeti dveh odmerkov zdravila.
English: • changes in urination (including urinating more frequently or in larger amounts, urgent need to urinate, need to urinate at night)
Slovenian: • spremembe pri uriniranju (vključno s pogostejšim odvajanjem urina ali z odvajanjem večjih količin urina, z občutkom nuje po uriniranju in s potrebo po uriniranju ponoči)
English: Urine laboratory assessments
Slovenian: Laboratorijske preiskave urina
English: • feeling thirsty
Slovenian: • občutek žeje
English: Diabetic ketoacidosis**
Slovenian: redki diabetična ketoacidoza**
English: • if you are on medicines to lower your blood pressure (anti-hypertensives) or have ever had low blood pressure (hypotension).
Slovenian: • če jemljete zdravila za zniževanje krvnega tlaka (antihipertenzive) in ste že kdaj imeli znižan krvni tlak (hipotenzijo).
English: The effect of being homozygote (UGT1A9*3/*3, frequency < 0.1%) is probably more marked, but has not been investigated.
Slovenian: (UGT1A9*3/*3, pogostnost < 0,1%), vendar tega niso preiskovali.
English: The hazard ratios for the 100 mg and 300 mg doses were similar.
Slovenian: Razmerji ogroženosti za odmerek 100 mg in 300 mg sta bili podobni.
English: The pharmacokinetics of canagliflozin are essentially similar in healthy subjects and patients with type 2 diabetes.
Slovenian: Farmakokinetika kanagliflozina je v bistvu enaka pri zdravih osebah in pri bolnikih s sladkorno boleznijo tipa 2.
English: Monotherapy (26 weeks)
Slovenian: Monoterapija (26 tednov)
English: • if you have ever had serious heart disease or if you have had a stroke
Slovenian: • če ste že imeli katero od resnih bolezni srca ali ste preživeli možgansko kap
English: This is because this medicine can affect the way some other medicines work.
Slovenian: To zdravilo lahko namreč vpliva na delovanje nekaterih drugih zdravil, pa tudi nekatera druga zdravila lahko vplivajo na delovanje tega zdravila.
English: When this happens, sugar (glucose) builds up in the blood.
Slovenian: Če pride do tega, se raven sladkorja (glukoze) v krvi zviša.
English: Each tablet contains 117.78 mg lactose.
Slovenian: Ena tableta vsebuje 117,78 mg laktoze.
English: Invokana has not been studied in patients with type 1 diabetes and is therefore not recommended for use in these patients.
Slovenian: Zdravila Invokana niso proučevali pri bolnikih s sladkorno boleznijo tipa 1, zato uporaba pri teh bolnikih ni priporočena.
English: There was no notable change in heart rate.
Slovenian: Pri tem ni prišlo do opazne spremembe srčne frekvence.
English: Each tablet contains 39.2 mg lactose.
Slovenian: Ena tableta vsebuje 39,2 mg laktoze.
English: Two hundred eleven (211) patients from the clinical study in older patients participated in a body composition substudy using DXA body composition analysis.
Slovenian: Dvestoenajst (211) bolnikov iz klinične študije s starejšimi bolniki je sodelovalo v podskupini, v kateri so bolnikom analizirali sestavo telesa z metodo DEXA.
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking or continuing to take this medicine.
Slovenian: Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali s farmacevtom, preden vzamete to zdravilo ali preden nadaljujete z jemanjem tega zdravila.
English: The marketing authorisation holder shall submit the first periodic safety update report for this product within 6 months following authorisation.
Slovenian: • Redno posodobljena poročila o varnosti zdravila (PSUR) Imetnik dovoljenja za promet z zdravilom mora prvo redno posodobljeno poročilo o varnosti zdravila za to zdravilo predložiti v 6 mesecih po pridobitvi dovoljenja za promet.
English: The 100 mg tablet also contains iron oxide yellow (E172).
Slovenian: 100 mg tablete vsebujejo tudi rumeni železov oksid (E172).
English: The racial distribution was 72% White, 16% Asian, 4% Black, and 8% other groups.
Slovenian: Pripadnost različnim rasam je bila naslednja: 72% bolnikov je bilo bele rase, 16% azijske rase, 4% črne rase, 8% je bilo pripadnikov drugih etničnih skupin.
English: Older patients
Slovenian: Starejši bolniki
English: Invokana should not be used during pregnancy.
Slovenian: Zdravila Invokana se ne sme jemati med nosečnostjo.
English: No clinically relevant effect on CYP3A4 was observed in vivo (see section 4.5).
Slovenian: In vivo niso opazili klinično pomembnega učinka na CYP3A4 (glejte poglavje 4.5).
English: A study in juvenile rats administered canagliflozin from day 1 through day 90 postnatal did not show increased sensitivity compared to effects observed in adults rats.
Slovenian: Študija pri podganjih mladičih, ki so jim dajali kanagliflozin od 1. do 90. dne po skotitvi, ni pokazala povečane občutljivosti v primerjavi z učinki, ki so jih opazili pri odraslih podganah.
English: In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute clinical measures if required.
Slovenian: V primeru prevelikega odmerjanja je smiselno začeti z običajnimi podpornimi ukrepi, kot so odstranjevanje nabsorbiranega zdravila iz prebavil, klinično spremljanje bolnika in uvedba kliničnih ukrepov, če so potrebni.
English: There are no data from the use of canagliflozin in pregnant women.
Slovenian: Ni podatkov o uporabi kanagliflozina pri nosečnicah.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with canagliflozin in one or more subsets of the paediatric population in type 2 diabetes (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij s kanagliflozinom za eno ali več podskupin pediatrične populacije pri sladkorni bolezni tipa 2 (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: It is unknown whether canagliflozin and/or its metabolites are excreted in human milk.
Slovenian: Ni znano ali se kanagliflozin in/ali njegovi presnovki izločajo v materino mleko.
English: Most reports of vulvovaginal candidiasis occurred during the first four months of treatment with canagliflozin.
Slovenian: Do večine poročil o vulvovaginalni kandidozi je prišlo v prvih štiri mesecih zdravljenja s kanagliflozinom.
English: It is not known if DKA is more likely to occur with higher doses of canagliflozin.
Slovenian: Ni znano, ali je DKA verjetnejša pri večjih odmerkih kanagliflozina.
English: • digoxin or digitoxin (medicines used for certain heart problems).
Slovenian: • digoksin ali digitoksin (zdravili, ki ju uporabljamo pri določenih boleznih srca).
English: * Related to volume depletion; see section 4.4.
Slovenian: * v povezavi s hipovolemijo; glejte poglavje 4.4.
English: 10 x 1 film-coated tablets 30 x 1 film-coated tablets 90 x 1 film-coated tablets 100 x 1 film-coated tablets
Slovenian: 10 x 1 filmsko obložena tableta 30 x 1 filmsko obložena tableta 90 x 1 filmsko obložena tableta 100 x 1 filmsko obložena tableta
English: This may occur regardless of blood glucose level.
Slovenian: To se lahko pojavi ne glede na koncetracije glukoze v krvi.
English: These increases in canagliflozin exposure are not expected to be clinically relevant.
Slovenian: Ni pričakovano, da bi bila ta povečanja izpostavljenosti kanagliflozinu klinično pomembna.
English: Less than 1% of the dose was excreted as unchanged canagliflozin in urine.
Slovenian: V urinu se je izločil manj kot 1% odmerka nespremenjenega kanagliflozina.
English: The risk of developing diabetic ketoacidosis may be increased with prolonged fasting, excessive alcohol consumption, dehydration, sudden reductions in insulin dose, or a higher need of insulin due to major surgery or serious illness.
Slovenian: Tveganje za razvoj diabetične ketoacidoze je lahko povečano v primeru dolgotrajnega stradanja, prekomernega uživanja alkohola, dehidracije, nenadnega zmanjšanja odmerka insulina ali povečane potrebe po insulinu zaradi večjega kirurškega posega ali resne bolezni.
English: • If your doctor has prescribed canagliflozin along with any bile acid sequestrant such as cholestyramine (medicines for lowering cholesterol) you should take canagliflozin at least 1 hour before or 4 hours to 6 hours after the bile acid sequestrant.
Slovenian: • Če vam je zdravnik predpisal kanagliflozin skupaj z adsorbentom žolčnih kislin, kot je holestiramin (zdravilo za zniževanje holesterola v krvi), morate vzeti kanagliflozin vsaj 1 uro prej ali 4 do 6 ur po tem, ko ste vzeli adsorbent žolčnih kislin.
English: The majority of genital mycotic infections were treated with topical antifungal treatments, either prescribed by a healthcare professional or self-treated while continuing therapy with Invokana.
Slovenian: Genitalne glivične okužbe so večinoma zdravili z lokalnimi antimikotiki, ki jih je bodisi predpisal zdravnik ali pa so se bolniki z njimi zdravili sami, zdravljenje z zdravilom Invokana pa so pri tem nadaljevali.
English: • rifampicin (an antibiotic used to treat tuberculosis)
Slovenian: • rifampicin (antibiotik, ki ga uporabljamo pri zdravljenju tuberkuloze)
English: In rare instances, phimosis was reported and sometimes circumcision was performed.
Slovenian: V redkih primerih so poročali o fimozi in v nekaj primerih so izvedli cirkumcizijo.
English: Patients had an overall mean age of 59.6 years (range 21 years to 96 years), with 3,082 patients ≥ 65 years of age and 510 patients ≥ 75 years of age.
Slovenian: Povprečna starost vseh bolnikov je bila 59,6 let (od 21 do 96 let), pri čemer je bilo 3.082 bolnikov starih najmanj 65 let, 510 bolnikov pa najmanj 75 let.
English: Treatment should be interrupted in patients who are hospitalised for major surgical procedures or acute serious medical illnesses.
Slovenian: Pri bolnikih, ki so hospitalizirani zaradi večjih kirurških posegov ali resnih akutnih bolezni, je treba zdravljenje prekiniti.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: • kidney failure (mainly as a consequence of loss of too much fluid from your body).
Slovenian: • ledvična odpoved (kot posledica prevelike izgube tekočine iz telesa)
English: Balanitis or balanoposthitis occurred primarily in uncircumcised male patients.
Slovenian: Do balanitisa oziroma balanopostitisa je prihajalo predvsem pri moških bolnikih, ki niso bili obrezani.
English: In in vitro studies, canagliflozin neither inhibited cytochrome P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, or CYP2E1, CYP2B6, CYP2C8, CYP2C9, nor induced CYP1A2, CYP2C19, CYP2B6, CYP3A4 at higher than therapeutic concentrations.
Slovenian: V in vitro študijah kanagliflozin pri odmerkih, višjih od terapevtskih, ni niti zaviral izoencimov citokroma P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, ali CYP2E1, CYP2B6, CYP2C8, CYP2C9, niti induciral CYP1A2, CYP2C19, CYP2B6, CYP3A4.
English: Male and female patients with a history of genital mycotic infections were more likely to develop an infection.
Slovenian: Pri bolnikih moškega in ženskega spola, ki so imeli genitalno glivično okužbo v anamnezi, je bila verjetnost za razvoj okužbe večja.
English: INFORMATION IN BRAILLE invokana 100 mg invokana 300 mg
Slovenian: PODATKI V BRAILLOVI PISAVI invokana 100 mg invokana 300 mg
English: Patients should be advised to report symptoms of volume depletion.
Slovenian: Bolnikom je treba naročiti, naj zdravniku povedo za simptome hipovolemije.
English: If you take more of this medicine than you should, talk to a doctor straight away.
Slovenian: Če ste vzeli večji odmerek zdravila Invokana, kot bi smeli Če vzamete več zdravila, kot bi smeli, takoj obvestite zdravnika.
English: This happens more often in elderly people (aged 75 and over), people with kidney problems, and people taking water tablets (diuretics).
Slovenian: Pogosteje se pojavi pri starejših ljudeh (starih 75 let ali več), pri ljudeh z boleznijo ledvic in pri ljudeh, ki jemljejo zdravila za odvajanje vode (diuretike).
English: These symptoms could be a sign of “diabetic ketoacidosis” - a problem you can get with diabetes because of increased levels of “ketone bodies” in your urine or blood, seen in tests.
Slovenian: Ti simptomi so lahko znaki “diabetične ketoacidoze” - motnje, ki se lahko pojavi pri sladkorni bolezni zaradi povečane koncentracije “ketonskih teles” v urinu in krvi, kar pokažejo laboratorijske preiskave.
English: The Leydig cell tumours are associated with an increase in luteinizing hormone (LH), which is a known mechanism of Leydig cell tumour formation in rats.
Slovenian: Tumorji Leydigovih celic so povezani zvišanjem koncentracije luteinizirajočega hormona (LH), kar je že znan mehanizem tvorbe tumorja Leydigovih celic pri podganah.
English: Experience in New York Heart Association (NYHA) class III is limited, and there is no experience in clinical studies with canagliflozin in NYHA class IV.
Slovenian: Pri bolnikih razreda III po Newyorškem združenju za srce (NYHA - New York Heart Association) je izkušenj malo, pri bolnikih razreda NYHA IV v okviru kliničnih študij ni nobenih izkušenj z uporabo kanagliflozina.
English: Invokana is indicated in adults aged 18 years and older with type 2 diabetes mellitus to improve glycaemic control as:
Slovenian: Zdravilo Invokana je indicirano pri odraslih, starih 18 let ali več, ki imajo sladkorno bolezen tipa 2, za izboljšanje urejenosti glikemije kot:
English: Monitoring of renal function is recommended as follows: - Prior to initiation of canagliflozin and at least annually, thereafter (see sections 4.2, 4.8, 5.1, and
Slovenian: Priporočeno je spremljanje delovanja ledvic, in sicer: - pred uvedbo kanagliflozina, nato pa najmanj enkrat na leto (glejte poglavja 4.2, 4.8, 5.1 in 5.2)
English: Inhibition of BCRP by canagliflozin cannot be excluded at an intestinal level and increased exposure may therefore occur for medicinal products transported by BCRP, e.g. certain statins like rosuvastatin and some anti-cancer medicinal products.
Slovenian: Zaviranja BCRP v črevesju s kanagliflozinom ni mogoče izključiti, zato lahko pride do povečane izpostavljenosti zdravilom, ki jih prenaša BCRP (npr. nekateri statini, kot je rosuvastatin in nekatere učinkovine za zdravljenje rakavih bolezni).
English: Available pharmacodynamic/toxicological data in animals have shown excretion of canagliflozin/metabolites in milk, as well as pharmacologically mediated effects in breast-feeding offspring and juvenile rats exposed to canagliflozin (see section 5.3).
Slovenian: Razpoložljivi farmakološki/toksikološki podatki pri živalih kažejo, da se kanagliflozin oz. njegovi presnovki izločajo v mleko, kot tudi farmakološke učinke na dojene mladiče in mlade podgane, ki so bile izpostavljene kanagliflozinu (glejte poglavje 5.3).