FrancophonIA/ELRC3.0 huggingface dataset:
English: ART-experienced with no darunavir resistance associated mutations (DRV-RAMs) and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Croatian: - su prethodno liječeni ART-om, koji nemaju mutacije povezane s rezistencijom na darunavir (DRV-RAM) i koji imaju plazmatsku koncentraciju HIV-1 RNK < 100 000 kopija/ml i broj CD4+ stanica ≥ 100 stanica x 10
English: looks like and contents of the pack Film-coated tablets (tablets) are orangish brown, oval, biconvex, engraved with a mark S2 on one side.
Croatian: Kako Darunavir Krka d.d. izgleda i sadržaj pakiranja Filmom obložene tablete (tablete) su narančastosmeđe, ovalne, bikonveksne, s utisnutom oznakom S2 na jednoj strani.
English: Amitriptyline Desipramine Imipramine Nortriptyline paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
Croatian: Sertralin paroksetin AUC ↓ 39% paroksetin Cmin ↓ 37% paroksetin Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49%
English: It is not recommended to coadminister darunavir with low dose ritonavir and simeprevir.
Croatian: Ne preporučuje se istodobna primjena darunavira s niskom dozom ritonavira i simeprevira.
English: rifabutin Cmax darunavir AUC ↑ 53% darunavir Cmin ↑ 68% darunavir Cmax ↑ 39% sum of active moieties of rifabutin (parent drug + 25-O-desacetyl metabolite) The interaction trial showed a comparable daily systemic exposure for rifabutin between treatment at 300 mg once daily alone and 150 mg once every other day in combination with darunavir/ritonavir (600/100 mg twice daily) with an about 10fold increase in the daily exposure to the active metabolite 25-O-desacetylrifabutin.
Croatian: Ispitivanje interakcije pokazalo je usporedivu dnevnu sistemsku izloženost za rifabutin između liječenja s 300 mg jedanput na dan samostalno i 150 mg jedanput svaki drugi dan u kombinaciji s darunavirom/ritonavirom (600/100 mg dvaput na dan) uz oko 10 puta veću dnevnu izloženost aktivnom metabolitu 25-O-desacetilrifabutinu.
English: is 800 milligram (2 tablets containing 400 milligram of Darunavir Krka d.d.
Croatian: Doza može biti: - 800 miligrama lijeka Darunavir Krka d.d. (2 tablete koje sadrže 400 miligrama lijeka Darunavir Krka d.d. ili 1 tableta koja sadrži 800 miligrama lijeka
English: General disorders and administration site conditions common asthenia, fatigue uncommon pyrexia, chest pain, peripheral oedema, malaise, feeling hot, irritability, pain rare chills, abnormal feeling, xerosis
Croatian: Opći poremećaji i reakcije na mjestu primjene često astenija, umor manje često pireksija, bol u prsištu, periferni edem, malaksalost, osjećaj vrućine, iritabilnost, bol rijetko zimica, nenormalno osjećanje, kseroza
English: Take your other HIV medicines used in combination with Darunavir Krka d.d.
Croatian: - Ostale lijekove protiv HIV-a koje primjenjujete istodobno s lijekom Darunavir
English: Amlodipine, diltiazem, disopyramide, carvedilol, felodipine, flecainide, lidocaine, metoprolol, mexiletine, nifedipine, nicardipine, propafenone, timolol, verapamil (for heart disease) as the therapeutic effect or side effects of these medicines may be increased.
Croatian: Obavijestite liječnika ako uzimate: - amlodipin, diltiazem, dizopiramid, karvedilol, felodipin, flekainid, lidokain, metoprolol, meksiletin, nifedipin, nikardipin, propafenon, timolol, verapamil (za bolest srca), jer se terapijski učinak ili nuspojave tih lijekova mogu pojačati - apiksaban, edoksaban, rivaroksaban, varfarin (smanjuje zgrušavanje krvi), jer terapijski učinak ili nuspojave mogu biti izmijenjene; liječnik će Vam možda htjeti provjeriti krvnu sliku - hormonska kontracepcija na bazi estrogena i hormonska nadomjesna terapija, jer im Darunavir Krka d.d. može smanjiti učinkovitost.
English: Darunavir is expected to increase these antipsychotic plasma concentrations.
Croatian: Očekuje se da će darunavir povećati koncentracije tih antipsihotika u plazmi. (CYP3A inhibicija).
English: 800 mg film-coated tablets darunavir
Croatian: Darunavir Krka d.d. 800 mg filmom obložene tablete darunavir
English: Co-administration of darunavir with these anticoagulants may increase concentrations of the anticoagulant, which may lead to an increased bleeding risk.
Croatian: Edoksaban Rivaroksaban darunavira s ovim antikoagulansima može povećati koncentracije antikoagulansa, što može povećati rizik od krvarenja. (CYP3A i/ili P-gp inhibicija)
English: 600 mg film-coated tablets darunavir
Croatian: Darunavir Krka d.d. 600 mg filmom obložene tablete darunavir
English: 375 mg darunavir/50 mg ritonavir twice daily
Croatian: 375 mg darunavir /50 mg ritonavir dvaput na dan
English: Darunavir/ritonavir 800/100 mg once daily N=343
Croatian: darunavir/ ritonavir 800/100 mg jedanput na dan N=343
English: a reaction called DRESS [severe rash, which may be accompanied by fever, fatigue, swelling of the face or lymph glands, increase of eosinophils (type of white blood cells), effects on liver, kidney or lung] heart attack, slow heart beating, palpitations visual disturbance chills, feeling abnormal a feeling of confusion or disorientation, altered mood, restlessness fainting, epileptic fits, changes or loss of taste mouth sores, vomiting blood, inflamation of the lips, dry lips, coated tongue running nose skin lesions, dry skin stiffness of muscles or joints, joint pain with or without inflammation changes in some values of your blood cells or chemistry.
Croatian: umorom, oticanjem lica ili limfnih čvorova, povišenjem eozinofila (vrsta bijelih krvnih stanica), učincima na jetru, bubreg ili pluća] - srčani udar, spori otkucaji srca, osjećaj lupanja srca - poremećaj vida - zimica, nenormalno osjećanje - osjećaj smetenosti ili dezorijentacije, promijenjeno raspoloženje, nemir - nesvjestica, epileptički napadaji, promjene ili gubitak okusa - ranice u ustima, povraćanje krvi, upala usnica, suhe usnice, obložen jezik - curenje nosa
English: 30 film-coated tablets: EU/1/17/1248/001 60 film-coated tablets: EU/1/17/1248/002 90 film-coated tablets: EU/1/17/1248/003 180 film-coated tablets: EU/1/17/1248/004
Croatian: 30 filmom obloženih tableta: EU/1/17/1248/001 60 filmom obloženih tableta: EU/1/17/1248/002 90 filmom obloženih tableta: EU/1/17/1248/003 180 filmom obloženih tableta: EU/1/17/1248/004
English: 30 film-coated tablets: EU/1/17/1248/005 60 film-coated tablets: EU/1/17/1248/006 90 film-coated tablets: EU/1/17/1248/007 180 film-coated tablets: EU/1/17/1248/008
Croatian: 30 filmom obloženih tableta: EU/1/17/1248/005 60 filmom obloženih tableta: EU/1/17/1248/006 90 filmom obloženih tableta: EU/1/17/1248/007 180 filmom obloženih tableta: EU/1/17/1248/008
English: 800 mg darunavir/100 mg ritonavir once daily
Croatian: 800 mg darunavir /100 mg ritonavir jedanput na dan
English: might reduce its effectiveness.
Croatian: To će poboljšati
English: EU/1/17/1248/005 30 film-coated tablets EU/1/17/1248/006 60 film-coated tablets EU/1/17/1248/007 90 film-coated tablets EU/1/17/1248/008 180 film-coated tablets
Croatian: EU/1/17/1248/005 30 filmom obloženih tableta EU/1/17/1248/006 60 filmom obloženih tableta EU/1/17/1248/007 90 filmom obloženih tableta EU/1/17/1248/008 180 filmom obloženih tableta
English: (CYP3A induction)
Croatian: CYP3A.
English: EU/1/17/1248/001 30 film-coated tablets EU/1/17/1248/002 60 film-coated tablets EU/1/17/1248/003 90 film-coated tablets EU/1/17/1248/004 180 film-coated tablets
Croatian: EU/1/17/1248/001 30 filmom obloženih tableta EU/1/17/1248/002 60 filmom obloženih tableta EU/1/17/1248/003 90 filmom obloženih tableta EU/1/17/1248/004 180 filmom obloženih tableta
English: must be taken in combination with a low dose of ritonavir and other anti-HIV medicines.
Croatian: Darunavir Krka d.d. se mora uzimati u kombinaciji s niskom dozom ritonavira i drugim lijekovima protiv HIV-a.
English: 400 mg film-coated tablets darunavir
Croatian: Darunavir Krka d.d. 400 mg filmom obložene tablete darunavir
English: Dose for children 3 years of age and above, weighing more than 40 kilograms who have taken antiretroviral medicines before (your child's doctor will determine this) The dose is either: 800 milligram Darunavir Krka d.d.
Croatian: Doza za djecu u dobi od 3 godine i više, težine najmanje 40 kilograma koja nisu prethodno uzimala antiretrovirusne lijekove (to će odrediti liječnik Vašeg djeteta) - Uobičajena doza lijeka Darunavir Krka d.d. je 800 miligrama (2 tablete koje sadrže 400 miligrama lijeka Darunavir Krka d.d. ili 1 tableta koja sadrži 800 miligrama lijeka Darunavir Krka d.d.) zajedno sa 100 miligrama ritnavira jednaput na dan.
English: administered with boosted darunavir but a careful clinical monitoring for signs of opiate toxicity is recommended.
Croatian: Prilagodba doze buprenorfina možda neće biti potrebna kada se primjenjuje istodobno s pojačanim darunavirom, ali se preporučuje pažljivo kliničko praćenje znakova opijatne toksičnosti.
English: darunavir/ritonavir 600/100 mg twice daily N=298
Croatian: darunavir/ritonavir 600/100 mg dvaput na dan N=298
English: which cannot be administered with these 400 or 800 milligram tablets.
Croatian: Možda ćete trebati drugačiju dozu lijeka Darunavir Krka d.d. koja se ne može primijeniti s ovim tabletama od 400 miligrama ili 800 miligrama.
English: The child must take the appropriate doses of Darunavir Krka d.d.
Croatian: Liječnik će odrediti jesu li za Vaše dijete prikladne tablete lijeka Darunavir Krka d.d.
English: Pregnant or breast-feeding mothers should not take Darunavir Krka d.d.
Croatian: Trudnice ili dojilje ne smiju uzimati Darunavir Krka d.d. osim ako to liječnik posebno ne odredi.
English: CD4+ cell count mean change from baseline a
Croatian: Srednja vrijednost promjene broja CD4+ stanica u odnosu na početni a
English: Response (HIV-1 RNA < 50 copies/ml at week
Croatian: Odgovor (HIV-1 RNK < 50 kopija/ml u 24. tjednu) %, n/N
English: is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) infection.
Croatian: Darunavir Krka d.d. je antiretrovirusni lijek koji se koristi za liječenje infekcije uzrokovane virusom humane imunodeficijencije (HIV).
English: KRKA Farmacéutica, S.L.
Croatian: Ελλάδα QUALIA PHARMA S.A.
English: Some side effects are typical for anti-HIV medicines in the same family as Darunavir Krkad.d..
Croatian: Neke su nuspojave tipične za lijekove protiv HIV-a koji spadaju u istu skupinu kao i Darunavir Krka d.d. To su: - bol u mišićima, osjetljivost na dodir ili slabost.
English: 400 mg and 800 mg tablets can be used to construct the once daily 800 mg regimen.
Croatian: Tablete Darunavir Krka d.d. od 400 mg i 800 mg mogu se uzimati za dostizanje jednokratne doze od 800 mg.
English: Boosted darunavir can be used with these NRTIs without dose adjustment.
Croatian: Pojačan darunavir se može primijeniti s didanozinom bez prilagodbe doze.
English: Because of both the potential for HIV transmission and the potential for adverse reactions in breast-fed infants, mothers should be instructed not to breast-feed under any circumstances if they are receiving Darunavir Krka d.d..
Croatian: Majke koje primaju lijek Darunavir Krka d.d. se mora uputiti da ni pod kojim uvjetima ne doje zbog mogućeg prijenosa virusa HIV-a i zbog mogućih nuspojava u dojene dojenčadi.
English: If you take more Darunavir Krkad.d.than you should Contact your doctor, pharmacist or nurse immediately.
Croatian: Odmah kontaktirajte svog liječnika, ljekarnika ili medicinsku sestru.
English: Dose for children 3 years of age and above, weighing more than 40 kilograms who have not taken antiretroviral medicines before (your child's doctor will determine this) The usual dose of Darunavir Krka d.d.
Croatian: Doza za djecu u dobi od 3 godine i više, težine najmanje 15 kilograma koja prethodno nisu uzimala antiretrovirusne lijekove (to će odrediti liječnik Vašeg djeteta)
English: For clinical trial results in ART-naïve paediatric patients aged 12 to 17 years, refer to the Summary of Product Characteristics for Darunavir Krka d.d.
Croatian: Rezultate kliničkih ispitivanja u pedijatrijskih bolesnika koji nisu liječeni ART-om u dobi od 12 do 17 godina, pogledajte u sažetku opisa svojstava lijeka za lijek Darunavir Krka d.d. 400 mg i 800 mg tablete.
English: Amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine to treat certain heart disorders e.g. abnormal heart beat Lovastatin, simvastatin and lomitapide to lower cholesterol levels Rifampicin to treat some infections such as tuberculosis
Croatian: liječenje gihta ili obiteljske mediteranske vrućice lurasidon, pimozid, kvetiapin ili sertindol liječenje psihijatrijskih stanja ergot alkaloidi kao što su ergotamin, dihidroergotamin, ergometrin i metilergonovin liječenje migrenskih glavobolja amiodaron, bepridil, dronedaron, ivabradin, kinidin i ranolazin liječenje određenih srčanih poremećaja npr. abnormalni otkucaji srca lovastatin, simvastatin i lomitapid snižavanje razina kolesterola rifampicin liječenje nekih infekcija poput tuberkuloze kombinirani lijek lopinavir/ritonavir ovaj lijek protiv HIV-a pripada istoj skupini kao i Darunavir Krka d.d.
English: together with 100 milligram ritonavir once a day.
Croatian: Darunavir Krka d.d.) zajedno sa 100 miligrama ritonavira jedanput na dan.
English: Treatment-naïve darunavir/cobicistat 800/150 mg once daily + OBR N=295
Croatian: Prethodno neliječeni darunavir/kobicistat 800/150 mg jedanput na dan + OBR N=295
English: Artemether/lumefantrine (a combination medicineto treat malaria) Dasatinib, everolimus,irinotecan,nilotinib, vinblastine, vincristine (to treat cancer) Sildenafil, tadalafil, vardenafil (for erectile dysfunction or to treat a heart and lung disorder called pulmonary arterial hypertension)
Croatian: Ako se ne mogu primijeniti alternativni lijekovi, ovi lijekovi se smiju primjenjivati samo nakon medicinske procjene te uz pomni liječnički nadzor zbog nuspojava kortikosteroida. - buprenorfin/nalokson (lijekovi za liječenje ovisnosti o opioidima) - salmeterol (lijek za liječenje astme) - artemeter/lumefantrin (kombinirani lijek za liječenje malarije) - dasatinib, everolimus, irinotekan, nilotinib, vinblastin, vinkristin (za liječenje raka) - sildenafil, tadalafil, vardenafil (za liječenje erektilne disfunkcije ili srčanog i plućnog poremećaja koji se naziva plućna arterijska hipertenzija) - glekaprevir/pibrentasvir, simeprevir (za liječenje infekcije hepatitisom C) - fentanil, oksikodon, tramadol (za liječenje boli) - fesoterodin, solifenacin (liječenje poremećaja mokraćnog sustava).
English: Darunavir/ritonavir 800/100 mg once daily N=294
Croatian: darunavir/ritonavir 800/100 mg jedanput na dan N=294
English: darunavir/ritonavir 600/100 mg twice daily N=296
Croatian: darunavir/ritonavir 600/100 mg dvaput na dan N=296
English: Your doctor should do blood tests before you start Darunavir Krka d.d..
Croatian: Prije započinjanja lijeka Darunavir Krka d.d. liječnik Vam treba napraviti krvne pretrage.
English: Co-administration of boosted darunavir and alfuzosin is contraindicated (see section 4.3).
Croatian: Istodobna primjena pojačanog darunavira s alfuzozinom je kontraindicirana (vidjeti dio 4.3).
English: Treatment-experienced darunavir/cobicistat 800/150 mg once daily + OBR N=18
Croatian: Prethodno liječeni darunavir/kobicistat 800/150 mg jedanput na dan + OBR N=18
English: Pharmacokinetic results of total darunavir after administration of darunavir/ritonavir at 600/100 mg
Croatian: Farmakinetički rezultati ukupnog darunavira nakon primjene darunavira/kobicistata
English: The pharmacokinetics of darunavir in combination with ritonavir taken twice daily in 14 treatmentexperienced paediatric patients, aged 3 to < 6 years and weighing at least 15 kg to < 20 kg, showed that weight-based dosages resulted in darunavir exposure that was comparable to that achieved in adults receiving darunavir/ritonavir 600/100 mg twice daily (see section 4.2).
Croatian: Farmakokinetika darunavira u kombinaciji s ritonavirom uzetih dvaput na dan, u 14 prethodno liječenih pedijatrijskih bolesnika u dobi 3 do < 6 godina s težinom najmanje 15 kg do < 20 kg, pokazala je da doziranje ovisno o tjelesnoj težini rezultira izloženošću darunaviru koja je usporediva s onom u odraslih koji primaju darunavir/ritonavir od 600/100 mg dvaput na dan (vidjeti dio 4.2).
English: Other strengths of Darunavir Krka d.d.
Croatian: Dostupne su druge jačine lijeka Darunavir Krka d.d.
English: Simeprevir simeprevir AUC ↑ 159% simeprevir Cmin ↑ 358% simeprevir Cmax ↑ 79% darunavir AUC ↑ 18% darunavir Cmin ↑ 31% darunavir Cmax ↔
Croatian: Simeprevir simeprevir AUC ↑ 159% simeprevir Cmin ↑ 358% simeprevir Cmax ↑ 79% darunavir AUC ↑ 18% darunavir Cmin ↑ 31% darunavir Cmax ↔ Doza simeprevira u ovom ispitivanju interakcija bila je 50 mg kada se istodobno primjenjivao u kombinaciji s darunavirom/ritonavirom, u usporedbi sa 150 mg u skupini liječenoj samim simeprevirom.
English: 400 mg film-coated tablets Darunavir Krka d.d.
Croatian: Darunavir Krka d.d. 400 mg filmom obložene tablete Darunavir Krka d.d. 800 mg filmom obložene tablete
English: Ergot alkaloids like ergotamine, dihydroergotamine, ergometrine and methylergonovine to treat migraine headaches
Croatian: (vidjeti dio 4.5) - ergot derivate (npr. dihidroergotamin, ergometrin,ergotamin, metilergonovin) - elbasvir/grazoprevir - cisaprid - dapoksetin - domperidon
English: Darunavir/ritonavir 600/100 mg twice daily + OBR N=298
Croatian: Ishodi darunavir/ritonavir 600/100 mg dvaput na dan + OOR N=298
English: Darunavir/ritonavir 600/100 mg twice daily + OBR N=296
Croatian: darunavir/ritonavir 600/100 mg dvaput na dan + OOR N=296
English: Clorazepate Diazepam
Croatian: ANTINEOPLASTICI Dasatinib
English: • For the treatment of HIV-1 infection in antiretroviral treatment (ART)-experienced adult patients, including those that have been highly pre-treated.
Croatian: Darunavir Krka d.d. od 600 mg tablete mogu se primjenjivati da bi se osigurali prikladni režimi doziranja (vidjeti dio 4.2): - Za liječenje HIV-1 infekcije u odraslih bolesnika prethodno liječenih antiretrovirusnom terapijom (ART), uključujući bolesnike koji su prethodno bili liječeni u znatnoj mjeri.
English: contains the active substance darunavir.
Croatian: Darunavir Krka d.d. sadrži djelatnu tvar darunavir.
English: muscle pain, tenderness or weakness.
Croatian: Poremećaji dišnog sustava, prsišta i sredoprsja
English: Boosted darunavir may increase the exposure to grazoprevir.
Croatian: Pojačan darunavir može povećati izloženost grazopreviru. (CYP3A i OATP1B inhibicija)
English: Saquinavir: comparison of saquinavir/ritonavir 1,000/100 mg twice daily vs. saquinavir/darunavir/ritonavir 1,000/400/100 mg twice daily Darunavir: comparison of darunavir/ritonavir 400/100 mg twice daily vs. darunavir/ritonavir 400/100 mg in combination with saquinavir 1,000 mg twice daily.
Croatian: Sakvinavir 1000 mg dvaput dnevno darunavir AUC ↓ 26% darunavir Cmin ↓ 42% darunavir Cmax ↓ 17% sakvinavir AUC ↓ 6% sakvinavir Cmin ↓ 18% sakvinavir Cmax ↓ 6% Sakvinavir: usporedba sakvinavira/ritonavira 1000/100 mg dvaput na dan naspram sakvinavira/darunavira/ritonavira 1000/400/100 mg dvaput na dan Darunavir: usporedba darunavira/ritonavira 400/100 mg dvaput na dan naspram darunavira/ritonavira 400/100 mg u kombinaciji sa sakvinavirom 1000 mg dvaput na dan.
English: You will require a different dose of Darunavir Krka d.d.
Croatian: Ako uzmete više lijeka Darunavir Krka d.d. nego što ste trebali
English: Do not combine Darunavir Krka d.d.
Croatian: Nemojte kombinirati Darunavir Krka d.d. ni s jednim od sljedećih lijekova
English: and darunavir co-administered with low dose ritonavir may increase plasma concentrations of salmeterol.
Croatian: Istodobna primjena salmeterola i darunavira primijenjenog istodobno s niskom dozom ritonavira može povećati koncentracije salmeterola u plazmi.
English: Saquinavir 1,000 mg twice daily darunavir AUC ↓ 26% darunavir Cmin ↓ 42% darunavir Cmax ↓ 17% saquinavir AUC ↓ 6% saquinavir Cmin ↓ 18% saquinavir Cmax ↓ 6%
Croatian: 400/100 mg dvaput na dan lopinavir AUC ↑ 9% lopinavir Cmin ↑ 23% lopinavir Cmax ↓ 2% darunavir AUC ↓ 38%
English: Number of subjects with virologic failure a and phenotype data that show resistance to PIs at endpoint c, n/N
Croatian: Broj ispitanika s virološkim neuspjehom i odgovarajući fenotip na početku/na kraju liječenja koji pokazuju gubitak osjetljivosti na IP na ishodu u usporedbi s onim na početku liječenja, n/N
English: The Summary of Product Characteristics of cobicistat or ritonavir as appropriate, must therefore be consulted prior to initiation of therapy with darunavir.
Croatian: Stoga se, prije početka terapije darunavirom mora pročitati odgovarajući sažetak opisa svojstava lijeka za kobicistat ili ritonavir.
English: ART-experienced paediatric patients (3 to 17 years of age and weighing at least 40 kg) The dose of cobicistat to be used with darunavir in children less than 18 years of age has not been established.
Croatian: Pedijatrijski bolesnici koji su prethodno liječeni ART-om (u dobi od 3 do 17 godina i težine najmanje 40 kg)
English: together with 100 milligram ritonavir twice daily.
Croatian: 600 miligrama darunavira + 100 miligrama ritonavira dvaput na dan
English: 600 mg film-coated tablets
Croatian: Darunavir Krka d.d. 600 mg filmom obložene tablete
English: always together with 100 milligram of ritonavir.
Croatian: - Lijek Darunavir Krka d.d. uvijek uzimajte zajedno sa 100 miligrama ritonavira.
English: ethinylestradiol Cmax  14% with darunavir/cobicistat ethinylestradiol AUC ↓ 44% ethinylestradiol Cmin ↓ 62% ethinylestradiol Cmax ↓ 32% norethindrone AUC ↓ 14% norethindrone Cmin ↓ 30% norethindrone Cmax ↔ with darunavir/ritonavir
Croatian: etinilestradiol Cmax  14% s darunavirom/kobicistatom etinilestradiol AUC ↓ 44%
English: 120 (3x40) capsules
Croatian: 120 (3x40) kapsula
English: Date of latest renewal: 18 July 2014
Croatian: Datum posljednje obnove odobrenja: 18. srpnja 2014
English: - if you have ever had or might now have a hepatitis B infection.
Croatian: • ako ste ikada imali ili trenutno možda imate infekciju hepatitisom B.
English: - which days are your dosing days.
Croatian: • koji dani su Vaši dani za uzimanje lijeka.
English: This is because you must not be treated with Temomedac during pregnancy unless clearly indicated by your doctor.
Croatian: To je zbog toga što se ne smijete liječiti lijekom Temomedac tijekom trudnoće, osim ako ga Vaš liječnik nije izričito propisao.
English: - if you are older than 70 years of age, you might be more prone to infections, bruising or bleeding.
Croatian: • ako ste stariji od 70 godina, možete biti skloniji infekcijama, stvaranju modrica ili krvarenju.
English: Always take Temomedac exactly as your doctor has told you.
Croatian: Uvijek uzmite Temomedac točno onako kako Vam je rekao liječnik.
English: CTC Grade 4b a:
Croatian: CTC stupanj 4b a:
English: What Temomedac is and what it is used for
Croatian: Što je Temomedac i za što se koristi
English: What Temomedac looks like and contents of the pack
Croatian: Kako Temomedac izgleda i sadržaj pakiranja
English: Other medicines and Temomedac
Croatian: Drugi lijekovi i Temomedac
English: If Temomedac comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Croatian: Ako Temomedac dođe u kontakt s kožom ili sluznicom, to područje treba odmah temeljito isprati sapunom i vodom.
English: - if you vomit frequently before or during treatment, ask your doctor about the best time to take Temomedac until the vomiting is under control.
Croatian: Ako često povraćate prije ili za vrijeme liječenja, upitajte svog liječnika u koje je vrijeme najbolje uzimati Temomedac dok povraćanje ne bude pod kontrolom.