FrancophonIA/ELRC3.0 huggingface dataset:
English: The incidence of clinically significant bleeding was similar to that observed when thrombolytic agents and heparin are co-administered with ASA (see section 4.8).
Danish: Hyppigheden af klinisk signifikant blødning var den samme som den, der ses, når trombolytiske midler og heparin indgives samtidig med ASA (se pkt.
English: - Tablet core: microcrystalline cellulose, colloidal anhydrous silica, crospovidone (type A), macrogol 6000, hydrogenated castor oil - Film-coating: hydroxypropylcellulose (E463), titanium dioxide (E171), red iron oxide (E172), talc and propylene glycol.
Danish: De øvrige indholdsstoffer er: - Tabletkernen: mikrokrystallinsk cellulose, vandfri kolloid silica, crospovidon (type A), macrogol 6000, hydrogeneret ricinusolie, - Filmovertrækket: hydroxypropylcellulose (E463), titandioxid (E171), rødt jernoxid (E172), talcum og propylenglycol.
English: Retroperitoneal haemorrhage
Danish: Retroperitoneal blødning
English: • Adults patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or established peripheral arterial
Danish: • Voksne patienter med myokardieinfarkt (fra få dage, men ikke over 35 dage), iskæmisk apopleksi (fra 7 dage, men ikke over 6 måneder) eller påviste perifere kredsløbsforstyrrelser.
English: As with other antiplatelet agents, clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions and in patients receiving treatment with ASA, heparin, glycoprotein IIb/IIIa inhibitors or non-steroidal anti-inflammatory drugs (NSAIDs) including Cox-2 inhibitors.
Danish: Ligesom andre antitrombolytika skal clopidogrel anvendes med forsigtighed til patienter med risiko for tiltagende blødninger pga. traumer, kirurgi eller andre patologiske tilstande samt til patienter, der samtidigt behandles med ASA, heparin, glycoprotein IIb/IIIa-hæmmere eller non-steroide antiinflammatoriske lægemidler (NSAID'er) inklusive cox-2-hæmmere.
English: The prevalence of CYP2C19 alleles that result in intermediate and poor CYP2C19 metabolism differs according to race/ethnicity (see Pharmacogenetics).
Danish: Hyppigheden af CYP2C19-alleler, der resulterer i moderat eller ringe CYP2C19-metabolisme, varierer afhængigt af race/etnisk tilhørsforhold (se farmakogenetik).
English: Serum sickness, anaphylactoid reactions
Danish: Serumsygdom, anafylaktiske reaktioner
English: In CHARISMA and one cohort study (Simon), an increased event rate was observed only in poor metabolisers when compared to extensive metabolisers.
Danish: I CHARISMA og et ken kohortestudie (Simon), sås kun en øget hyppighed af hændelser hos personer med poor metabolisme, i sammenligning med personer med extensive metabolisme.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Qualimed, 117 allee des Parcs, 69 800 Saint Priest, France
Danish: NAVN OG ADRESSE PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN Qualimed, 117 allee des Parcs, 69 800 Saint Priest, Frankrig
English: Tests are available to determine a patient's CYP2C19 genotype.
Danish: Der er tests tilgængelige til at bestemme en patients CYP2C19- genotype.
English: Patients should be told that it might take longer than usual to stop bleeding when they take clopidogrel (alone or in combination with ASA), and that they should report any unusual bleeding (site or
Danish: Patienter i behandling med clopidogrel (alene eller i kombination med ASA) bør informeres om, at det kan tage længere tid end normalt at standse blødninger, samt at de bør kontakte deres læge ved enhver usædvanlig blødning (sted eller varighed).
English: Since clopidogrel is metabolised to its active metabolite partly by CYP2C19, use of medicinal products that inhibit the activity of this enzyme would be expected to result in reduced drug levels of the active metabolite of clopidogrel.
Danish: Da clopidogrel til dels metaboliseres til dets aktive metabolit af CYP2C19, kan anvendelse af medicin, der hæmmer aktiviteten af dette enzym, forventes at resultere i nedsat niveau af clopidogrels aktive metabolit.
English: If you think any of these apply to you, or if you are in any doubt at all, consult your doctor before taking Clopidogrel Qualimed.
Danish: Hvis De mener, at ovenstående gælder for Dem, eller hvis De overhovedet er i tvivl, så rådfør Dem med deres læge, inden De tager Clopidogrel Qualimed.
English: The CLARINET and the PICOLO trials were conducted using a constituted solution of clopidogrel.
Danish: CLARINET- og PICOLO-studierne blev udført ved brug af en opløsning af clopidogrel.
English: Bleeding may occur as bleeding in the stomach or bowels, bruising, haematoma (unusual bleeding or bruising under the skin), nose bleed, blood in the urine.
Danish: Blødning kan forekomme i form af blødninger fra mave eller tarm, blå mærker, usædvanlig blødning eller blodudtrædning under huden (hæmatom), næseblod, blod i urinen.
English: Less pronounced reductions of metabolite exposure has been observed with pantoprazole or
Danish: Der er observeret mindre udtalte reduktioner af eksponeringen for den aktive metabolit med pantoprazol og lansoprazol.
English: WHAT CLOPIDOGREL QUALIMED IS AND WHAT IT IS USED FOR Clopidogrel Qualimed belongs to a group of medicines called antiplatelet medicinal products.
Danish: VIRKNING OG ANVENDELSE Clopidogrel Qualimed tilhører en gruppe medicin, der kaldes blodfortyndende medicin.
English: However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 2 ‘Take special care with Clopidogrel
Danish: Hvis De er bekymret over Deres blødning, skal De omgående kontakte Deres læge (se afsnit 2 ”Vær ekstra forsigtig med at tage Clopidogrel Qualimed”).
English: Boxes of 30x1 and 50x1 film-coated tablets in perforated unit dose blisters are available.
Danish: Æsker med 30x1 og 50x1 filmovertrukne tabletter i perforerede enkeltdosisblisterpakninger.
English: Therefore clopidogrel should be used with caution in these patients (see section 4.2).
Danish: Derfor skal clopidogrel anvendes med forsigtighed til disse patienter (se pkt.
English: The pharmacokinetics of digoxin or theophylline were not modified by the co-administration of clopidogrel.
Danish: Hverken digoxins eller theofyllins farmakokinetik blev ændret ved samtidig administration af clopidogrel.
English: In CURE, CLARITY and one of the cohort studies (Trenk), no increased event rate was observed
Danish: I CURE, CLARITY og et af kohortestudier (Trenk) blev der ikke observeret nogen øget forekomst af hændelser, baseret på metabolismestatus.
English: Always take Clopidogrel Qualimed exactly as your doctor has told you.
Danish: Tag altid Clopidogrel Qualimed nøjagtigt efter lægens anvisning.
English: Each film-coated tablet contains 13 mg hydrogenated castor oil.
Danish: Hver filmovertrukken tablet indeholder 13 mg hydrogeneret ricinusolie.
English: - swelling in the mouth or skin disorders such as rashes and itching, blisters of the skin.
Danish: - hævelser i munden eller hudproblemer såsom udslæt og kløe, blærer på huden.
English: Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation.
Danish: Clopidogrel skal metaboliseres af CYP450-enzymer for at danne den aktive metabolit, der hæmmer trombocytaggregationen.
English: The Cmax of the active metabolite is twice as high following a single 300-mg clopidogrel loading dose as it is after four days of 75-mg maintenance dose.
Danish: Cmax for den aktive metabolit er dobbelt så høj efter en enkelt 300 mg clopidogrel initial stabiliseringmætningsdosis på 300 mg clopidogrel, som den er efter fire dage med 75 mg vedligeholdelsesdosis.
English: These occurred at doses representing at least 25 times the exposure seen in humans receiving the clinical dose of 75 mg/day and were a consequence of an effect on hepatic metabolising enzymes.
Danish: De optrådte ved doser, der var mindst 25 gange højere end de kliniske doser på 75 mg/dag til mennesker, og var en konsekvens af virkningen på levermetaboliseringsenzymerne.
English: However, patients entered into clinical trials with clopidogrel received a variety of concomitant medicinal products including diuretics, beta blockers, ACEI, calcium antagonists, cholesterol lowering agents, coronary vasodilators, antidiabetic agents (including insulin), antiepileptic agents, and GPIIb/IIIa antagonists without evidence of clinically significant adverse interactions.
Danish: Imidlertid fik de patienter, som indgik i kliniske studier med clopidogrel, en lang række lægemidler samtidigt, såsom diuretika, beta-blokkere, ACE-hæmmere, calcium-antagonister, kolesterolsænkende midler, dilatatorer med effekt på koronarkarrene, antidiabetika (inklusive insulin), antiepileptika samt GPIIb/IIIa-hæmmere, uden at der blev påvist klinisk signifikante uønskede interaktioner.
English: Absorption is at least 50%, based on urinary
Danish: Absorptionen er mindst 50% baseret på urinudskillelse af clopidogrels metabolitter.
English: Acetylsalicylic acid (ASA): ASA did not modify the clopidogrel-mediated inhibition of ADP-induced platelet aggregation, but clopidogrel potentiated the effect of ASA on collagen-induced platelet aggregation.
Danish: Acetylsalicylsyre (ASA): ASA ændrede ikke på, at clopidogrel hæmmer den trombocytaggregation som ADP inducerer, men clopidogrel forstærkede virkningen af ASA på trombocytaggregationen, som kollagen inducerer.
English: Qualimed, 117 allee des Parcs, 69 800 Saint Priest, France
Danish: INDEHAVER AF MARKEDSFØRINGSTILLADELSEN Qualimed, 117 allee des Parcs, 69 800 Saint Priest, Frankrig
English: A pharmacodynamic interaction between clopidogrel and heparin is possible, leading to increased risk of bleeding.
Danish: Der er mulighed for en farmakodynamisk interaktion mellem clopidogrel og heparin, som kan medføre øget blødningsrisiko.
English: In a subgroup analysis by qualifying condition (myocardial infarction, ischaemic stroke, and PAD) the benefit appeared to be strongest (achieving statistical significance at p = 0.003) in patients enrolled due to PAD (especially those who also had a history of myocardial infarction) (RRR = 23.7%; CI: 8.9 to 36.2) and weaker (not significantly different from ASA) in stroke patients (RRR = 7.3%; CI: -5.7 to 18.7 [p=0.258]).
Danish: I en delgruppeanalyse af inklusionsgrupperne (myokardieinfarkt, iskæmisk slagtilfælde og PAD) syntes udbyttet at være størst (dvs. den opnåede statisk signifikans ved p=0,003) hos patienter, som indgik på grund af PAD (især de patienter, som tidligere også havde haft et myokardieinfarkt) (RRR = 23,7%, CI: 8,9 til 36,2) og mindst (afveg ikke signifikant fra ASA) hos patienter med slagtilfælde (RRR = 7,3%, CI: -5,7 til 18,7 [p=0,258]).
English: A pharmacodynamic interaction between clopidogrel and acetylsalicylic acid is possible, leading to increased risk of bleeding.
Danish: Der er mulighed for en farmakodynamisk interaktion mellem clopidogrel og acetylsalicylsyre, som kan medføre øget blødningsrisiko.
English: Clopidogrel active metabolite pharmacokinetics and antiplatelet effects, as measured by ex vivo platelet aggregation assays, differ according to CYP2C19 genotype.
Danish: Farmakokinetikken og den antitrombotiske effekt af den aktive metabolit, målt ved ex vivo trombocytaggregationsundersøgelser, adskiller sig alt efter CYP2C19 genotype.
English: Animal studies have shown excretion of clopidogrel in breast milk.
Danish: Dyreforsøg har vist, at clopidogrel udskilles i modermælken.
English: Following an oral dose of 14C-labelled clopidogrel in man, approximately 50% was excreted in the urine and approximately 46% in the faeces in the 120-hour interval after dosing.
Danish: Elimination Efter en oral dosis af 14C-mærket clopidogrel hos mennesker blev ca. 50% udskilt i urinen og ca. 46%
English: The pharmacokinetics of the active metabolite of clopidogrel is not known in these special
Danish: Farmakokinetikken af clopidogrels aktive metabolit er ikke kendt i nedenstående særlige patientgrupper.
English: Acute liver failure, hepatitis, abnormal liver function test
Danish: Akut leversvigt, hepatitis, unormal leverfunktionstest
English: Glycoprotein IIb/IIIa inhibitors: clopidogrel should be used with caution in patients receive concomitant glycoprotein IIb/IIIa inhibitors (see section 4.4).
Danish: Glycoprotein IIb/IIIa-hæmmere: Clopidogrel skal anvendes med forsigtighed til patienter, hvor patienten samtidigt behandles med glycoprotein IIb/IIIa-hæmmere (se pkt.
English: Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Danish: Syrepumpehæmmere (PPI) .80 mg omeprazol en gang daglig administreret enten samtidig med clopidogrel eller med 12 timers mellemrum nedsatte eksponeringen for den aktive metabolit med 45 % (ved initial mætningsdosis) og 40 % (vedligeholdelsesdosis).
English: EFFECTIVE USE OF THE MEDICINAL PRODUCT
Danish: Brug af anden medicin
English: INFORMATION IN BRAILLE Clopidogrel Qualimed 75 mg
Danish: INFORMATION I BRAILLE-SKRIFT Clopidogrel Qualimed 75 mg
English: No antidote to the pharmacological activity of clopidogrel has been found.
Danish: Der er ikke fundet en aktiv farmakologisk antidot til clopidogrel.
English: Platelets are very small structures in the blood, which clump together during blood clotting.
Danish: Blodplader er meget små bestanddele i blodet, mindre end de røde og hvide blodlegemer, og de klumper sig sammen, når blodet størkner.
English: NSAIDs: in a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and naproxen increased occult gastrointestinal blood loss.
Danish: Nonsteroide antiinflammatoriske stoffer (NSAID'er): I et klinisk studie foretaget med raske forsøgspersoner øgede den samtidige administration af clopidogrel og naproxen okkult gastrointestinalt blodtab.
English: Mylan AB Tlf: + 46 8-555 227 50 (Sverige)
Danish: Tlf: + 46 8-555 227 50 (Sverige)
English: You have been prescribed Clopidogrel Qualimed to help prevent blood clots and reduce the risk of - You have a condition of hardening of arteries (also known as atherosclerosis), and - You have previously experienced a heart attack, stroke or have a condition known as peripheral
Danish: De har fået ordineret Clopidogrel Qualimed til forebyggelse af blodpropper og nedsættelse af risikoen for disse alvorlige hændelser, fordi: - De lider af åreforkalkning (også kaldet aterosklerose) - og - De tidligere har haft et hjerteanfald, apopleksi eller kredsløbsforstyrrelser i arme eller ben.
English: While you are taking Clopidogrel Qualimed:
Danish: Mens De tager Clopidogrel Qualimed:
English: However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 4
Danish: Hvis De er bekymret over Deres blødning, skal De omgående kontakte Deres læge (se afsnit 4 ”Bivirkninger”).
English: Perforated unit dose blister of OPA/Al/PVC-Al containing 30x1 and 50x1 film-coated tablets in the box.
Danish: Perforerede dosisblistere af OPA/PVC aluminium eller aluminium i kartonæsker indeholdende 30x1 og 50x1 filmovertrukne tabletter.
English: The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Danish: Clopidogrels aktive metabolit hæmmer selektivt bindingen af adenosindiphosphat (ADP) til dets trombocytreceptor P2Y12 og den efterfølgende ADP-medierede aktivering af GBIIb-IIIa-komplekset, hvorved trombocytaggregationen hæmmes.
English: - fluconazole, voriconazole, ciprofloxacin, or chloramphenicol, medicines to treat bacterial and
Danish: − fluconazol, voriconazol, ciprofloxacin eller chloramphfenicol, der anvendes til behandling af bakterie- og svampeinfektioner,
English: Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of
Danish: Den trombocytaggregation, der induceres af andre agonister end ADP, hæmmes også ved blokering af den forstærkning af trombocytaktiveringen, der udløses af frigivet ADP.
English: Musculo-skeletal bleeding (haemarthrosis), arthritis, arthralgia, myalgia
Danish: Muskuloskeletal blødning (blodudtrædning i led), artritis, artralgi, myalgi
English: - a recent serious injury - a recent surgery (including dental) - a planned surgery (including dental) in the next seven days
Danish: - en blødningsforstyrrelse, der giver Dem tendens til indre blødning (blødning i et af kroppens væv, organer eller led) - en nylig alvorlig skade - en nylig operation (herunder tandoperation) - en planlagt operation (herunder tandoperation) inden for de næste 7 dage
English: Clopidogrel Qualimed is unlikely to affect your ability to drive or to use machines.
Danish: Trafik- og arbejdssikkerhed Det er usandsynligt, at Clopidogrel Qualimed påvirker Deres evne til at køre eller betjene maskiner.
English: In CAPRIE, in patients treated with either clopidogrel or ASA, the overall incidence of any bleeding was 9.3%.
Danish: I CAPRIE var den generelle forekomst af blødninger 9,3 % hos patienter behandlet med enten clopidogrel eller ASA.
English: - If you have any further questions, ask your doctor or pharmacist.
Danish: Er De i tvivl, så spørg lægen eller på apoteket.
English: Other concomitant therapy:
Danish: Anden samtidig behandling:
English: Rash, pruritus, skin bleeding (purpura)
Danish: Udslæt, kløe, hudblødning (purpura)
English: France Qualimed
Danish: Qualimed
English: Oral anticoagulants: the concomitant administration of clopidogrel with oral anticoagulants is not recommended since it may increase the intensity of bleedings (see section 4.4).
Danish: Orale antikoagulantia: Samtidig administration af clopidogrel og orale antikoagulantia kan ikke anbefales, da det kan øge blødningstendensen (se pkt.
English: Pharmacogenetics: In patients who are poor CYP2C19 metabolisers, clopidogrel at recommended doses forms less of the active metabolite of clopidogrel and has a smaller effect on platelet function.
Danish: Farmakogenetik: Hos patienter med nedsat CYP2C19-metabolisme omdannes en mindre del af den anbefalede dosis af clopidogrel til den aktive metabolit og har derfor en mindre effekt på trombocytfunktionen (se pkt.
English: Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation.
Danish: Clopidogrel er et prodrug, hvor en af metabolitterne hæmmer trombocyaggregationen.
English: The dose of 0.2 mg/kg achieved the mean percent inhibition of 49.3% (5 µM ADP-induced platelet aggregation) which was comparable to that of adults taking
Danish: En dosis på 0,2 mg/kg opnåede en gennemsnitlig procentvis hæmning på 49,3% (5 µM ADP-induceret trombocytaggregation), hvilket er sammenligneligt med voksne, der tager Plavix 75 mg/dag.
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 75 mg of clopidogrel (as hydrochloride).
Danish: KVALITATIV OG KVANTITATIV SAMMENSÆTNING Hver filmovertrukken tablet indeholder 75 mg clopidogrel (som hydrochlorid).
English: At very high doses, a poor gastric tolerability (gastritis, gastric erosions and/or vomiting) of clopidogrel was also reported in rat and baboon.
Danish: Ved meget høje doser clopidogrel blev der hos rotter og bavianer observeret dårlig gastrisk tolerans (gastritis, gastriske erosioner og/eller opkastning).
English: Clopidogrel should not be used in children because of efficacy concerns (see section 5.1).
Danish: • Pædiatrisk population Clopidogrels bør ikke bruges til børn på grund af usikkerhed om virkningen (se pkt.
English: Therefore, concomitant use should be undertaken with caution (see section 4.4).
Danish: Der rådes derfor til forsigtighed ved samtidig brug (se pkt.
English: The concomitant administration of clopidogrel with oral anticoagulants is not recommended since it may increase the intensity of bleedings (see section 4.5).
Danish: Samtidig administration af clopidogrel og orale antikoagulantia kan ikke anbefales, da det kan øge blødningstendensen (se pkt.
English: • Renal impairment Therapeutic experience is limited in patients with renal impairment (see section 4.4).
Danish: • Nedsat nyrefunktion Der er kun begrænset erfaring med behandling af patienter med nedsat nyrefunktion (se pkt.
English: Each film-coated tablet contains 75 mg of clopidogrel (as hydrochloride).
Danish: Hver filmovertrukken tablet indeholder 75 mg clopidogrel (som hydrochlorid).
English: • not known (frequency cannot be estimated from the available data)
Danish: Meget sjælden (påvirker færre end 1 ud af 10.000 patienter) Ikke kendt (hyppigheden kan ikke fastlægges ud fra de tilgængelige data)
English: For further information please refer to section 5.1.
Danish: For yderligere information se pkt.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER (Boxes of 7, 14, 28, 30, 30x1, 50, 50x1, 56, 84, 90 and 100)
Danish: BLISTERKORT (ÆSKER MED 7, 14, 28, 30, 30x1, 50, 50x1, 56, 84, 90 og 100)
English: Uncommon side effects: Headache, stomach ulcer, vomiting, nausea, constipation, excessive gas in stomach or intestines, rashes, itching, dizziness, sensation of tingling and numbness.
Danish: Ikke almindelige bivirkninger: Hovedpine, mavesår, opkastninger, kvalme, forstoppelse, luft i maven eller tarmene, udslæt, kløe, svimmelhed, prikkende fornemmelse og følelsesløshed.
English: Co-administration of heparin had no effect on the inhibition of platelet aggregation induced by clopidogrel.
Danish: Samtidig administration af heparin havde ingen virkning på den hæmning af trombocytaggregationen, som clopidogrel inducerer.
English: Experience is limited in patients with moderate hepatic disease who may have bleeding diatheses.
Danish: Der er begrænset erfaring med clopidogrel til patienter med moderat leversygdom, som kan have blødningstendens.
English: Clopidogrel Qualimed is taken to prevent blood clots (thrombi) forming in hardened blood vessels (arteries), a process known as atherothrombosis, which can lead to atherothrombotic events (such as
Danish: Clopidogrel Qualimed tages for at forebygge dannelse af blodpropper (tromber) i blodårer (arterier), som er blevet stive ved en proces kaldet aterotrombose, hvilket kan føre til f.eks. apopleksi, hjerteanfald og død (aterotrombotiske hændelser).
English: Fertility Clopidogrel was not shown to alter fertility in animal studies.
Danish: Fertilitet I dyreforsøg blev det ikke vist, at Clopidogrel ændrerde fertiliteten.
English: At steady state, the average inhibition level observed with a dose of 75 mg per day was between 40% and
Danish: Ved steady state var den gennemsnitlige hæmningsgrad, der blev iagttaget med en dosis på
English: Mylan AB Tel: + 46 8-555 227 50
Danish: Tel: + 46 8-555 227 50
English: Detailed information is available on the European Medicines Agency website:
Danish: Yderligere information om dette lægemiddel er tilgængelig på Det europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu/.
English: BATCH RELEASE
Danish: BATCHNUMMER Batch:
English: Within each system organ class, adverse reactions are presented in order of decreasing seriousness.
Danish: Indenfor hver gruppe af bivirkninger med samme frekvens er bivirkningerne opstillet efter, hvor alvorlige de er.
English: From literature, limited data in Asian populations are available to assess the clinical implication of genotyping of this CYP on clinical outcome events.
Danish: I litteraturen er der kun få tilgængelige data, der tillader en vurdering af det kliniske udbytte af CYP2C19-genotypning i asiatiske befolkningsgrupper.
English: Due to the irreversible binding, platelets exposed are affected for the remainder of their lifespan (approximately 7-10 days) and recovery of normal platelet function occurs at a rate consistent with platelet turnover.
Danish: Clopidogrel binder sig irreversibelt til trombocytternes ADP-receptor, hvorfor trombocytaggregationen hæmmes i resten af trombocytternes levetid (ca. 7-10 dage), og normal trombocytfunktion generhverves med den hastighed, hvormed trombocytterne omsættes.