FrancophonIA/ELRC3.0 huggingface dataset:
English: Venlafaxine did not affect the pharmacokinetics of imipramine and 2-OH-imipramine.
Maltese: Venlafaxine ma affettwax il-farmakokinetika ta' imipramine u 2-OH-imipramine.
English: SPC Section 4.8 - Undesirable effects
Maltese: Sezzjoni 4.8 tal-SPC - Effetti mhux mixtieqa
English: FURTHER INFORMATION What Efexor contains The active substance is venlafaxine.
Maltese: Is-sustanza attiva hi venlafaxine.
English: SPC Section 4.2 - Posology and Method of Administration The MAH was asked to harmonize the following posology texts in the SPC: - limitations of treatment duration of the maximum daily dose of 375mg to 4 weeks; - differences in maximum recommended daily dose.
Maltese: Sezzjoni 4.2 tal-SPC - Pożoloġija u metodu ta' kif għandu jingħata Il-MAH intalab jarmonizza t-testi li ġejjin dwar il-pożoloġija fl-SPC: - limitazzjonijiet tat-tul tat-trattament tad-doża massima ta' kuljum ta' 375mg għal 4 ġimgħat; - differenzi fid-doża massima rakkomandata ta' kuljum.
English: • Haloperidol or risperidone (to treat psychiatric conditions)
Maltese: • Haloperidol jew risperidone (għall-kura ta' kundizzjonijiet psikjatriċi)
English: The potential risk for humans is unknown.
Maltese: Irriskju potenzjali għall-bnedmin mhuwiex magħruf.
English: In dialysis patients, venlafaxine elimination half-life was prolonged by about 180% and clearance reduced by about 57% compared to normal subjects, while ODV elimination half-life was prolonged by about 142% and clearance reduced by about 56%.
Maltese: F'pazjenti li kienu fuq id-dijalisi, il-half-life ta' l-eliminazzjoni ta' venlafaxine twalet b'madwar 180% u t-tneħħija tnaqqset b'madwar 57% meta mqabbla ma' persuni normali, filwaqt li l-half-life ta' leliminazzjoni ta' ODV twalet b'madwar 142% u tneħħija tnaqqset b'madwar 56%.
English: The MAH was asked to harmonize Section 4.3, for which the following differences between SPCs needed to be evaluated - Monoamine oxidase inhibitors (MAOIs); - Cardiovascular safety - Uncontrolled hypertension.
Maltese: Il-MAH intalab jarmonizza s-Sezzjoni 4.3, li għal liema kellhom jiġu evalwati d-differenzi bejn lSPCs - Inibituri tal-Monoamine oxidase (MAOIs); - Sigurtà kardjovaskulari; - Pressjoni għolja mhux ikkontrollata.
English: In general, the adverse reaction profile of venlafaxine (in placebo-controlled clinical trials) in children and adolescents (ages 6 to 17) was similar to that seen for adults.
Maltese: B'mod ġenerali, il-profil tar-reazzjonijiet avversi ta' venlafaxine (fi provi kliniċi kkontrollati bilplaċebo) fit-tfal u fl-adolexxenti (età minn 6 sa 17) kien simili għal dak li kien osservat fl-adulti.
English: In clinical trials, adverse events seen on treatment discontinuation (tapering and post-tapering) occurred in approximately 35% of patients treated with venlafaxine and 17% of patients taking placebo.
Maltese: Fil-provi kliniċi, l-avvenimenti avversi li kienu osservati meta twaqqfet il-kura (mat-twaqqif gradwali u wara t-twaqqif gradwali) seħħew f'madwar 35% talpazjenti kkurati b'venlafaxine u fi 17% tal-pazjenti li kienu qed jieħdu l-plaċebo.
English: John Wyeth & Brothers Ltd, New Lane,
Maltese: Il-Finlandja John Wyeth & Brothers Ltd, New Lane,
English: Affects 1 to 10 users in 1,000
Maltese: Jaffettwaw minn 1 sa 10 utenti f'kull 1,000
English: You should avoid alcohol while you are taking Tradename.
Maltese: Għandek tevita l-alkoħol meta tkun qed tieħu Efexor.
English: Major Depressive Episodes: the CHMP considered that the maximum dose of 375mg/day Efexor is safe and effective in a long term perspective and recommended that it is approved without duration limitations in the harmonised SPC.
Maltese: Episodji Dipressivi Maġġuri: is-CHMP qies li d-doża massima ta' 375mg kuljum ta' Efexor hija sigura u effikaċi minn perspettiva fit-tul u rrakkomanda li din tkun approvata mingħajr limitazzjonjiet fir-rigward tat-tul ta' żmien fl-SPC armonizzat.
English: There are limited data in patients with severe hepatic impairment.
Maltese: Hemm dejta limitata f'pazjenti b'indeboliment epatiku sever.
English: Common: abnormal dreams; decreased libido; dizziness; increased muscle tonus; insomnia; nervousness; pins and needles; sedation; tremor; confusion; feeling separated (or detached) from yourself and reality
Maltese: Komuni: ħolm anormali; tnaqqis fil-libido; sturdament; żieda fit-tonus tal-muskoli; nuqqas ta' rqad; nervożità; sensazzjoni ta' tingiż; sedazzjoni; tregħid; konfużjoni; tħossok separat (jew maqtugħ) minnek innifsek u mir-realtà
English: Efexor is an antidepressant that belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors (SNRIs).
Maltese: Efexor hu anti-dipressant li jappartjeni għal grupp ta' mediċini msejħa inibituri ta' l-assorbiment millġdid ta' serotonin u norepinephrine (SNRIs).
English: The concomitant use of venlafaxine with serotonin precursors (such as tryptophan supplements) is not recommended (see section 4.4).
Maltese: venlafaxine ma' prekursuri ta' serotonin (bħal supplimenti ta' tryptophan) mhuwiex rakkomandat (ara sezzjoni 4.4).
English: • Medicines to treat depression, for instance SNRI, SSRIs, tricyclics, or medicines containing lithium
Maltese: • Mediċini biex jikkuraw id-dipressjoni, per eżempju SNRI, SSRIs, triċikliċi, jew mediċini li fihom il-lithium
English: Pharmacological activity at these receptors may be related to various side effects seen with other antidepressant medicinal products, such as anticholinergic, sedative and cardiovascular side effects.
Maltese: L-attività farmakoloġika f'dawn ir-riċetturi tista' tkun marbuta ma' diversi effetti sekondarji li kienu osservati ma' prodotti mediċinali anti-dipressanti oħrajn, bħal effetti sekondarji antikolinerġiċi, sedattivi u kardjovaskulari.
English: A meta-analysis of placebocontrolled clinical trials of antidepressant drugs in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Maltese: Meta-analiżi ta' provi kliniċi kkontrollati bil-plaċebo ta' mediċini kontra d-dipressjoni f'pazjenti adulti b'disturbi psikjatriċi, uriet żieda fir-riskju ta' mġiba suwiċidali bl-anti-dipressanti meta mqabbla mal-plaċebo f'pazjenti ta' inqas minn 25 sena.
English: • Triptans (used for migraine)
Maltese: • Triptans (jintużaw għall-emigranja)
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Maltese: Pazjenti bi problemi ereditarji rari ta' intolleranza għal galactose, ta' defiċjenza tal-lactase ta' Lapp jew ta' assorbiment ħażin ta' glucose-galactose, m'għandhomx jieħdu din il-mediċina.
English: Affects 1 to 10 users in 10,000
Maltese: Jaffettwaw minn 1 sa 10 utenti f'kull 10,000
English: Not known: a high temperature with rigid muscles, confusion or agitation, and sweating, or if you experience jerky muscle movements which you can't control, these may be symptoms of serious conditions known as neuroleptic malignant syndrome; euphoric feelings, drowsiness, sustained rapid eye movement, clumsiness, restlessness, feeling of being drunk, sweating or rigid muscles, which are symptoms of serotonergic syndrome; disorientation and confusion often accompanied by hallucination (delirium); stiffness, spasms and involuntary movements of the muscles; thoughts of harming or killing yourself
Maltese: Mhux Komuni: nuqqas ta' sensazzjoni jew emozzjoni; alluċinazzjonijiet; moviment involontarju tal-muskoli; aġitazzjoni; indeboliment fil-koordinazzjoni u fil-bilanċ Rari: sensazzjoni ta' nuqqas ta' kwiet f'ġismek jew nuqqas ta' ħila li toqgħod bilqiegħda jew bilwieqfa mingħajr ma titħarrek; aċċessjonijiet; tħossok eċċitat/a jew ewforiku/a żżejjed Mhux magħrufa: temperatura għolja flimkien ma' muskoli iebsin, konfużjoni jew aġitazzjoni, u għaraq, jew jekk ikollok movimenti għal għarrieda tal-muskoli li ma tistax tikkontrolla; dawn jistgħu jkunu sintomi ta' kundizzjonijiet serji magħrufa bħala sindrome malinn newroleptiku; sensazzjonijiet ewforiċi, ngħas, moviment mgħaġġel u sostnut ta' l-għajnejn, guffaġni, nuqqas ta' kwiet f'ġismek, tħossok qisek fis-sakra, għaraq jew muskoli iebsin, li huma sintomi ta' sindrome serotonerġiku; diżorjentament u konfużjoni ta' spiss akkompanjati minn alluċinazzjoni (delirju); ebusija, spażmi u movimenti involontarji tal-muskoli; ħsibijiet li tagħmel ħsara jew li toqtol lilek innifsek
English: PACKAGE LEFLET
Maltese: Kura rakkomandata
English: Mean ± SD plasma half-lives of venlafaxine and ODV are 5±2 hours and 11±2 hours, respectively.
Maltese: Il-medja ± SD tal-half-lives tal-plażma ta' venlafaxine u ODV huma ta' 5±2 sigħat u ta' 11±2 sigħat, rispettivament.
English: Serotonin syndrome may occur with the concomitant use of venlafaxine and lithium (see Serotonin syndrome).
Maltese: Is-sindrome ta' serotonin tista' jseħħ bl-użu fl-istess ħin ta' venlafaxine u lithium (ara Is-sindrome ta' serotonin).
English: • If you are a young adult.
Maltese: • Jekk inti adult żagħżugħ.
English: Plasma concentrations of venlafaxine are higher in CYP2D6 poor metabolisers than extensive metabolisers.
Maltese: Il-konċentrazzjonijiet fil-plażma ta' venlafaxine huma ogħla f'metabolizzaturi batuti ta' CYP2D6 milli f'metabolizzaturi estensivi.
English: Affects 1 to 10 users in 100
Maltese: Jaffettwaw minn 1 sa 10 utenti f'kull 100
English: John Wyeth & Brother Ltd trading as Wyeth Laboratories, Huntercombe Lane South, Taplow, Maidenhead, Berkshire SL6 0PH
Maltese: John Wyeth & Brother Ltd. li tagħmel il-kummerċ bħala Wyeth Laboratories, Huntercombe Lane South, Taplow,
English: • Medicines containing moclobemide, a reversible MAOI (used to treat depression)
Maltese: • Mediċini li fihom moclobemide, MAOI riversibbli (jintuża biex jikkura d-dipressjoni)
English: In vitro and in vivo studies indicate that venlafaxine is biotransformed to its major active metabolite, ODV, by CYP2D6.
Maltese: Studji in vitro u in vivo jindikaw li venlafaxine jiġi bijotrasformat għal metabolit attiv maġġuri tiegħu, ODV, minn CYP2D6.
English: SPC Section 4.1 - Therapeutic Indications
Maltese: Sezzjoni 4.1 tal-SPC - Indikazzjonijiet Terapewtiċi
English: Published retrospective studies report that venlafaxine overdosage may be associated with an increased risk of fatal outcomes compared to that observed with SSRI antidepressant products, but lower than that for tricyclic antidepressants.
Maltese: Studji retrospettivi ppubblikati jirrappurtaw li doża eċċessiva ta' venlafaxine tista' tkun marbuta ma' żieda fir-riskju ta' riżultati fatali meta mqabbla ma' dik osservata fi prodotti anti-dipressanti SSRI, iżda hi iktar baxxa minn dik għal anti-dipressanti triċikliċi.
English: Some patients may experience symptoms such as tiredness, dizziness, light-headedness, headache, sleeplessness, nightmares, dry mouth, loss of appetite, nausea, diarrhoea, nervousness, agitation, confusion, ringing in the ears, tingling or rarely, electric shock sensations, weakness, sweating, seizures or flu-like symptoms.
Maltese: Xi pazjenti jista' jkollhom sintomi bħal għeja, sturdament, mejt, uġigħ ta' ras, nuqqas ta' rqad, ħmar il-lejl, ħalq xott, telf ta' aptit, nawseja, dijarea, nervożità, aġitazzjoni, konfużjoni, tisfir fil-widnejn, tnemnim jew, rarament, sensazzjonijiet ta' xokk elettriku, dgħjufija, għaraq, aċċessjonijiet jew sintomi bħal ta' l-influwenza.
English: In a second longer-term study, the efficacy of venlafaxine in prevention of recurrent depressive episodes for a 12-month period was established in a placebo-controlled double-blind clinical trial in adult outpatients with recurrent major depressive episodes who had responded to venlafaxine treatment (100 to 200 mg/day, on a b.i.d.
Maltese: Fit-tieni studju li kien itwal, l-effikaċja ta' venlafaxine fil-prevenzjoni ta' episodji dipressivi rikorrenti għal perjodu ta' 12-il xahar, kienet stabbilita fi prova klinika ikkontrollata bil-plaċebo u double-blind f'pazjenti adulti outpatients li kellhom episodji dipressivi maġġuri rikorrenti, u li kienu rrispondew għall-kura b'venlafaxine (100 sa 200 mg/kuljum, fuq skeda b.i.d.) fl-aħħar episodju tad-dipressjoni.
English: Withdrawal symptoms seen on discontinuation of venlafaxine: based on a proposed text for the SPC for Selective Serotonin Reuptake Inhibitors (SSRIs) / Selective Norepinephrine Reuptake Inhibitors (SNRIs) (Sections 4.2, 4.4, and 4.8) reviewed by the Pharmacovigilance Working Party, it was agreed to incorporate this text into the harmonised SPC.
Maltese: Sintomi ta' rtirar li dehru mat-twaqqif ta' venlafaxine: skont test propost għall-SPC għall-Inibituri Selettivi tal-Assorbiment mill-Ġdid tas-Serotonin (SSRIs) u l-Inibituri Selettivi tal-Assorbiment millĠdid tan-Norepinephrine (SNRIs) (Sezzjonijiet 4.2, 4.4, u 4.8) analizzati mill-Grupp ta' Ħidma talFarmakoviġilanza, kien hemm qbil li jiġi inkorporat dan it-test fl-SPC armonizzata.
English: SPC Section 4.4 - Special Warnings and Precautions for Use The MAH was asked to harmonize Section 4.4, for which the following differences between SPCs needed to be evaluated: - the mentioning of reports of aggression in relation to starting and discontinuing treatment; - treatment of children and adolescents under the age of 18, which was recommended by the CHMP in 2005 to be included in Section 4.4 of the SPC (Commission Decision of 19-VIII-2005); With regards to the aggression reports, it was agreed to introduce a wording to indicate that aggression may occur in patients receiving venlafaxine, under initiation, dose changes and discontinuation of treatment.
Maltese: Sezzjoni 4.4 tal-SPC - Twissijiet Speċjali u Prekawzjonijiet għall-Użu Il-MAH intalab jarmonizza s-Sezzjoni 4.4, li għaliha kellhom jiġu evalwati d-differenzi li ġejjin bejn lSPCs: - li jissemmew rapporti ta' aggressjoni b'rabta mal-bidu u t-twaqqif tat-trattament; - it-trattament ta' tfal u adolexxenti taħt it-18-il sena, li ġie rrakkomandat mis-CHMP fl-2005 li għandu jiġi inkluż fis-Sezzjoni 4.4 tal-SPC (Deċiżjoni tal-Kummissjoni tad-19-VIII-2005);
English: Preclinical studies have shown that venlafaxine and its major metabolite, O-desmethylvenlafaxine (ODV), are inhibitors of serotonin and noradrenaline reuptake.
Maltese: Studji ta' qabel lużu kliniku wrew li venlafaxine u l-metabolit maġġuri tiegħu, O-desmethylvenlafaxine (ODV), huma inibituri ta' l-assorbiment mill-ġdid ta' serotonin u noradrenaline.
English: • If you have a history of aggressive behaviour.
Maltese: • Jekk għandek storja medika ta' imġiba aggressiva.
English: Yawning
Maltese: Nawseja
English: Postural hypotension, Syncope, Tachycardia
Maltese: Pressjoni baxxa li tiddependi millqagħda, Sinkope, Takikardija
English: Venlafaxine undergoes extensive hepatic metabolism.
Maltese: Venlafaxine jgħaddi minn metaboliżmu epatiku estensiv.
English: This may increase the risk of caries.
Maltese: Hemm riskju ta' effett fuq it-tarbija.
English: Very common: dry mouth; headache
Maltese: Mhux Komuni: tgħażżiż tas-snien; dijarea
English: A minority of CHMP members were of the opinion that this indication should be deleted from section 4.1, and a statement should be included in section 4.2, to indicate that longer-term treatment may also be appropriate for prevention of recurrence of major depressive episodes.
Maltese: Minoranza ta' membri tas-CHMP kienu tal-fehma li din l-indikazzjoni m'għandhiex titħassar mis-sezzjoni 4.1, u għandha tkun inkluża stqarrija fis-sezzjoni 4.2, biex tindika li t-trattament fit-tul jista' jkun xieraq ukoll għallprevenzjoni tar-rikorrenza ta' episodji dipressivi maġġuri.
English: Havant, Hants PO9 2NG
Maltese: PO9 2NG
English: • Digestive disorders
Maltese: • Disturbi diġestivi
English: Concomitant administration of venlafaxine and metoprolol to healthy volunteers in a pharmacokinetic interaction study for both medicinal products resulted in an increase of plasma concentrations of metoprolol by approximately 30-40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol.
Maltese: L-għoti fl-istess ħin ta' venlafaxine u metoprolol lil voluntiera b'saħħithom fi studju dwar linterazzjoni farmakokinetika għaż-żewġ prodotti mediċinali rriżulta f'żieda tal-konċentrazzjonijiet filplażma ta' metoprolol b'madwar 30-40% mingħajr l-ebda tibdil fil-konċentrazzjonijiet fil-plażma talmetabolit attiv tiegħu, α-hydroxymetoprolol.
English: 4.5 Interaction with other medicinal products and other forms of interaction Monoamine Oxidase Inhibitors (MAOI)
Maltese: Inibituri ta' Monoamine Oxidase (MAOI)
English: In patients with mild and moderate hepatic impairment, in general a 50% dose reduction should be considered.
Maltese: F'pazjenti b'indeboliment epatiku minn ħafif sa moderat, b'mod ġenerali għandu jiġi kkunsidrat tnaqqis ta' 50% fid-doża.
English: In the harmonized text of Section 4.4 it is indicated that non-selective MAOIs should not be given concomitantly, and that reversible, selective MAOIs such as moclobemide are not recommended in combination with venlafaxine, due to the risk of serotonin syndrome.
Maltese: Fit-test armonizzat tas-Sezzjoni 4.4 hemm indikat li l-MAOIs mhux selettivi m'għandhomx jingħataw fl-istess ħin, u l-użu ta' MAOIs selettivi riversibbli bħal moclobemide f'kombinazzjoni ma' venlafaxine mhuwiex rakkomandat, minħabba r-riskju tas-sindromu tas-serotonin.
English: Following review, chills, confusion, depersonalisation, headache, menstrual disorders, palpitations and pollakiuria were included in this table.
Maltese: Wara reviżjoni ġew miżjuda kesħiet, konfużjoni, depersonalizzazzjoni, uġiegħ ta' ras, disturbi fil-menstruwazzjoni, palpitazzjonijiet u pollakurja ġew inklużi f'din it-tabella.
English: Efexor and associated names (see Annex I) 25 mg tablets Efexor and associated names (see Annex I) 37.5 mg tablets Efexor and associated names (see Annex I) 50 mg tablets Efexor and associated names (see Annex I) 75 mg tablets
Maltese: Efexor u ismijiet assoċjati miegħu (ara Anness I) pilloli ta' 25 mg Efexor u ismijiet assoċjati miegħu, (ara Anness I) pilloli ta' 37.5 mg Efexor u ismijiet assoċjati miegħu, (ara Anness I) pilloli ta' 50 mg Efexor u ismijiet assoċjati miegħu, (ara Anness I) pilloli ta' 75 mg
English: • Medicines containing tramadol (a pain-killer)
Maltese: • Mediċini li fihom tramadol (itaffi l-uġigħ)
English: • This medicine has been prescribed for you.
Maltese: • Jekk għandek storja medika ta' aċċessjonijiet.
English: However, the CHMP considered that only non-selective, irreversible MAOIs should be contraindicated and that a strong warning in Section 4.4 and Section 4.5 of the SPC should be sufficient for the reversible MAOIs.
Maltese: Madankollu, is-CHMP qies li l-MAOIs irriversibbli mhux selettivi biss kellhom ikunu kontraindikati u li twissija qawwija fis-Sezzjoni 4.4 u s-Sezzjoni 4.5 tal-SPC għandhom ikunu suffiċjenti għall-MAOIs riversibbli.
English: Do not take Efexor
Maltese: Tiħux Efexor
English: Therefore, caution is advised if a patient's therapy includes a CYP3A4 inhibitor and venlafaxine concomitantly.
Maltese: Għalhekk, l-attenzjoni hi rakkomandata jekk it-terapija tal-pazjent tkun tinkludi inibitur ta' CYP3A4 u venlafaxine fl-istess ħin.
English: Venlafaxine has virtually no affinity for rat brain muscarinic, cholinergic, H1-histaminergic or α1-adrenergic receptors in vitro.
Maltese: Venlafaxine m'għandu kważi l-ebda affinità għar-riċetturi muskariniċi, kolinerġiċi, H1-istaminerġiċi jew α1-adrenerġici fil-moħħ tal-firien in vitro.
English: In one longer-term study, adult outpatients who had responded during an 8-week open trial on venlafaxine prolonged-release (75, 150, or 225 mg) were randomised to continuation of their same venlafaxine prolonged-release dose or to placebo, for up to 26 weeks of observation for relapse.
Maltese: Fi studju li dam għal żmien itwal, pazjenti adulti outpatients li kienu rrispondew matul prova miftuħa li damet 8 ġimgħat fuq venlafaxine li jintreħa bil-mod (75, 150, jew 225 mg) kienu randomised biex ikomplu fuq l-istess doża ta' venlafaxine li jintreħa bil-mod jew fuq il-plaċebo, sa 26 ġimgħa ta' osservazzjoni għal rikaduta.
English: Although no change in dosage is necessary for patients with glomerular filtration rate (GFR) between 30-70 ml/minute, caution is advised.
Maltese: Għalkemm l-ebda bidla fid-dożaġġ mhi meħtieġa għal pazjenti b'rata tal-filtrazzjoni glomerulari (GFR) bejn 30-70 ml/minuta, l-attenzjoni hi rakkomandata.
English: Narrow-angle glaucoma
Maltese: It-twaqqif tal-kura
English: • Nerve problems, such as dizziness, pins and needles, movement disorder, seizures or fits
Maltese: • Problemi fin-nervaturi: bħal sturdament, sensazzjoni ta' tingiż, disturb tal-moviment,
English: Cardiac disease and risk of arrhythmia
Maltese: Mard kardijaku u riskju ta' arritmija
English: In vitro and in vivo studies indicate that venlafaxine is a weak inhibitor of CYP2D6.
Maltese: Studji in vitro u in vivo jindikaw li venlafaxine hu inibitur dgħajjef ta' CYP2D6.
English: Medicinal products that inhibit serotonin uptake may lead to reduced platelet function.
Maltese: Prodotti mediċinali li jinibixxu l-assorbiment ta' serotonin jistgħu jwasslu għal tnaqqis fil-funzjoni talplejtlits.
English: Recommended treatment
Maltese: TAL-PRODOTT MEDIĊINALI
English: Common: yawning
Maltese: Isem (ivvintat)
English: Anorgasmia, Erectile dysfunction (impotence), Urination impaired (mostly hesitancy), Menstrual disorders associated with increased bleeding or increased irregular bleeding (e.g., menorrhagia, metrorrhagia), Pollakiuria
Maltese: Ejakulazzjoni/orgaż mu anormali (irġiel), Anorgażmija, Disfunzjoni erettili (impotenza), Indeboliment meta tagħmel l-awrina (laktar dewmien biex tibda tagħmel lawrina), Disturbi talmestrwazzjoni assoċjati ma' żieda fil-ħruġ tad-demm jew żieda fil-ħruġ ta' demm irregolari (eż., mestrwazzjoni esaġerata, tnixxija anormali tad-demm mill-ġuf), pollakijurja
English: Not known: slight changes in blood levels of liver enzymes; decrease in blood sodium levels; itchiness, yellow skin or eyes, dark urine, or flu-like symptoms, which are symptoms of inflammation of the liver (hepatitis); confusion, excessive water intake (known as SIADH); abnormal breast milk production
Maltese: Mhux magħrufa: tibdil żgħir fil-livelli ta' enzimi tal-fwied fid-demm; tnaqqis fil-livelli tassodium fid-demm; ħakk, sfura fil-ġilda jew fl-għajnejn, awrina skura, jew sintomi bħal dawk ta' l-influwenza, li huma sintomi ta' infjammazzjoni tal-fwied (epatite); konfużjoni, teħid eċċessiv ta' ilma (magħruf bħala SIADH); produzzjoni anormali ta' ħalib tas-sider
English: Venlafaxine has been shown not to increase the impairment of mental and motor skills caused by ethanol.
Maltese: Intwera li venlafaxine ma jżidx l-indeboliment tal-ħiliet mentali u tal-moviment ikkawżati millethanol.
English: Abnormal ejaculation/orgasm (males),
Maltese: Mhux Komuni: orgażmu anormali (nisa)
English: Venlafaxine must be discontinued for at least 7 days before starting treatment with an irreversible MAOI (see sections 4.4 and 4.5).
Maltese: Venlafaxine għandu jitwaqqaf għal mill-inqas 7 ijiem qabel ma tinbeda l-kura b'MAOI irriversibbli (ara sezzjonijiet 4.4 u 4.5).
English: • Muscle disorders Not known: unexplained muscle pain, tenderness or weakness (rhabdomyolysis)
Maltese: • Disturbi fil-muskoli Mhux magħrufa: uġigħ mhux spjegabbli fil-muskoli, sensittività jew dgħjufija (rabdomijolosi)
English: Imipramine did not affect the pharmacokinetics of venlafaxine and O-desmethylvenlafaxine.
Maltese: Imipramine ma affettwax il-farmakokinetika ta' venlafaxine u ta' O-desmethylvenlafaxine.
English: Do not stop taking Efexor without talking to your doctor (see the section “If you stop taking Efexor”).
Maltese: Tiqafx tieħu Efexor mingħajr ma tkellem lit-tabib tiegħek (ara s-sezzjoni “Jekk tieqaf tieħu Efexor”).
English: Venlafaxine and its active metabolite reduce β-adrenergic responsiveness after both acute (single dose) and chronic administration.
Maltese: Venlafaxine u l-metabolit attiv tiegħu jnaqqsu r-rispons β-adrenerġiku, wara kemm l-għoti akut (doża waħda) kif ukoll kroniku.