FrancophonIA/ELRC3.0 huggingface dataset:
English: Aclasta may also cause other side effects Very common (may affect more than 1 in 10 people) Fever
Croatian: Aclasta može uzrokovati i druge nuspojave Vrlo česte (mogu se javiti u više od 1 na 10 osoba) Vrućica
English: The total body clearance is 5.04 ± 2.5 l/h, independent of dose, and unaffected by gender, age, race or body weight.
Croatian: Ukupan tjelesni klirens je 5,04 ± 2,5 l/h, neovisno o dozi te na njega ne utječe spol, dob, rasa ili tjelesna težina.
English: For information on the infusion of Aclasta, see section 6.6.
Croatian: Za informacije o infuziji Aclaste, vidjeti dio 6.6.
English: Follow carefully all instructions given to you by your doctor or nurse.
Croatian: Pažljivo slijedite upute koje Vam je dao liječnik ili medicinska sestra.
English: Aclasta significantly decreased the incidence of one or more new vertebral fractures over three years and as early as the one year timepoint (see Table 2).
Croatian: Aclasta je značajno smanjila incidenciju jednog ili više novih vertebralnih prijeloma tijekom tri godine i najranije već tijekom jedne godine (vidi Tablicu 2).
English: If you are considering stopping Aclasta treatment, please go to your next appointment and discuss this with your doctor.
Croatian: Ako razmišljate o prekidu liječenja Aclastom, molimo otiđite na sljedeći pregled i raspravite odluku s liječnikom.
English: Osteoporosis could also occur in men and women because of the long term use of steroids, which can affect the strength of bones.
Croatian: Osteoporoza se također može pojaviti u muškaraca i žena zbog dugotrajnog korištenja steroida koji mogu utjecati na čvrstoću kosti.
English: The optimal duration of bisphosphonate treatment for osteoporosis has not been established.
Croatian: Optimalno trajanje liječenja osteoporoze bisfosfonatima nije utvrđeno.
English: ONJ can also occur after stopping treatment.
Croatian: ONJ se također može javiti nakon prestanka liječenja.
English: • in post-menopausal women
Croatian: • kod žena u postmenopauzi
English: The early disposition phases (α and β, with t½ values above) presumably represent rapid uptake into bone and excretion via the kidneys.
Croatian: Rane faze dispozicije (α i β, s t½ vrijednostima navedenim gore) vjerojatno predstavljaju brzu pohranu u kost i izlučivanje putem bubrega.
English: After 6 months, Aclasta showed 96% (169/176) and 89% (156/176) response and serum alkaline phosphatase (SAP) normalisation rates compared to 74% (127/171) and 58% (99/171) for risedronate (all p<0.001).
Croatian: Nakon 6 mjeseci, Aclasta je pokazala 96% (169/176) i 89% (156/176) odgovor i stope normalizacije razina alkalne fosfataze u serumu (SAP) u usporedbi s 74% (127/171) i 58% (99/171) za risedronat (za sve p<0,001).
English: Single and multiple 5 and 15-minute infusions of 2, 4, 8 and 16 mg zoledronic acid in 64 patients yielded the following pharmacokinetic data, which were found to be dose independent.
Croatian: Jednokratnim i višekratnim 5 i 15-minutnim infuzijama 2, 4, 8 i 16 mg zoledronatne kiseline u 64 bolesnika dobiveni su sljedeći farmakokinetički podaci, za koje se utvrdilo da ne ovise o dozi.
English: Your doctor can recommend a mild pain reliever such as ibuprofen or paracetamol to reduce these side effects.
Croatian: Liječnik će Vam preporučiti blagi lijek protiv bolova, poput ibuprofena ili paracetamola, kako bi se smanjile ove nuspojave.
English: Five of the 6 patients had SAP within the normal range at month 6 (Last Observation Carried Forward, LOCF).
Croatian: Pet od 6 bolesnika imalo je SAP unutar normalnog raspona u 6. mjesecu (prijenos posljednjih opaženih vrijednosti, eng.
English: The mean time of ending the Extended Observation Period due to the need for Paget's re-treatment from the initial dose was longer for zoledronic acid (7.7 years) than for risedronate (5.1 years).
Croatian: Srednje vrijeme završetka produljenog perioda praćenja zbog potrebe za ponovnim liječenjem Pagetove bolesti od početne doze bilo je dulje za zoledronatnu kiselinu (7,7 godina) nego za risedronat (5,1 godina).
English: Make sure you drink enough fluids (at least one or two glasses) before and after the treatment with Aclasta, as directed by your doctor.
Croatian: Pazite da popijete dovoljno tekućine (najmanje jednu ili dvije čaše) prije i nakon liječenja Aclastom, prema uputama liječnika.
English: The most frequent finding in the repeat-dose studies consisted of increased primary spongiosa in the metaphyses of long bones in growing animals at nearly all doses, a finding that reflected the compound's pharmacological antiresorptive activity.
Croatian: Najčešći nalaz u ispitivanjima s ponovljenim dozama sastojao se od povećanog primarnog spongioznog tkiva u metafizama dugih kostiju kod životinja u razvoju pri gotovo svim dozama, nalaz koji je odražavao farmakološko antiresorpcijsko djelovanje lijeka.
English: The inter- and intra-subject variation for plasma clearance of zoledronic acid was shown to be 36% and 34%, respectively.
Croatian: Pokazalo se da inter- i intra-individualno variranje u klirensu zoledronatne kiseline iz plazme iznosi 36%, odnosno 34%.
English: • in adult men at increased risk of fracture.
Croatian: • kod odraslih muškaraca s povećanim rizikom za prijelome.
English: Aclasta should not be used in children and adolescents below 18 years of age.
Croatian: Aclasta se ne smije primjenjivati u djece i adolescenata mlađih od 18 godina.
English: CARTON (WITH BLUE BOX) FOR UNIT PACK
Croatian: KUTIJA (S PLAVIM OKVIROM) ZA JEDINIČNO PAKIRANJE
English: The recommended dose is a single intravenous infusion of 5 mg Aclasta.
Croatian: Preporučena doza je jednokratna intravenska infuzija Aclaste u dozi od 5 mg.
English: Pharmacotherapeutic group: Drugs for treatment of bone diseases, bisphosphonates, ATC code: M05BA08
Croatian: Farmakoterapijska skupina: Lijekovi za liječenje bolesti kostiju, bisfosfonati, ATK oznaka: M05BA08 Mehanizam djelovanja
English: These transverse or short oblique fractures can occur anywhere along the femur from just below the lesser trochanter to just above the supracondylar flare.
Croatian: Ti poprečni ili kratki kosi prijelomi mogu nastati bilo gdje uzduž bedrene kosti od neposredno ispod malog trohantera do neposredno iznad suprakondilarnog dijela.
English: CARTON FOR INTERMEDIATE PACK (WITHOUT BLUE BOX)
Croatian: KUTIJA ZA SREDNJE PAKIRANJE (BEZ PLAVOG OKVIRA)
English: Clinical vertebral fracture (2)
Croatian: Klinički vertebralni prijelom (2)
English: Patients should be informed about symptoms of hypocalcaemia and receive adequate clinical monitoring during the period of risk.
Croatian: Bolesnike treba obavijestiti o simptomima hipokalcijemije te ih tijekom razdoblja rizika treba odgovarajuće klinički pratiti.
English: In both women and men, Aclasta strengthens the bone and therefore makes it less likely to break.
Croatian: I u žena i u muškaraca, Aclasta jača kost i na taj način smanjuje vjerojatnost prijeloma.
English: Other products containing zoledronic acid as an active substance are available for oncology indications.
Croatian: Drugi lijekovi koji sadrže zoledronatnu kiselinu kao djelatnu tvar dostupni su za onkološke indikacije.
English: Zoledronic acid was not mutagenic in the mutagenicity tests performed and carcinogenicity testing did not provide any evidence of carcinogenic potential.
Croatian: Zoledronatna kiselina se u provedenim ispitivanjima mutagenosti nije pokazala mutagenom, dok ispitivanje karcinogenosti nije dalo nikakav dokaz karcinogenog potencijala.
English: All cause mortality was 10% (101 patients) in the Aclasta-treated group compared to 13% (141 patients) in the placebo group.
Croatian: Smrtnost zbog svih uzroka bila je 10% (101 bolesnik) u skupini liječenih Aclastom u usporedbi s 13% (141 bolesnik) u placebo skupini.
English: Adverse reactions, such as dizziness, may affect the ability to drive or use machines.
Croatian: Nuspojave, kao što je omaglica, mogu utjecati na mogućnost upravljanja vozilima i rada sa strojevima.
English: - Concomitant therapies: corticosteroids, chemotherapy, angiogenesis inhibitors, radiotherapy to head and neck.
Croatian: - Istodobnu terapiju: kortikosteroide, kemoterapiju, inhibitore angiogeneze, radioterapiju glave i vrata.
English: You may eat normally on the day you are treated with Aclasta.
Croatian: Na dan kad ćete primiti Aclastu možete normalno jesti.
English: Tetracycline label was detectable in all but one of 82 biopsies obtained from patients on Aclasta.
Croatian: Tetraciklinsko obilježavanje nađeno je kod svih osim jedne od 82 biopsije koje su uzete od bolesnica na Aclasti.
English: - Patients with hypocalcaemia (see section 4.4).
Croatian: - Bolesnici s hipokalcijemijom (vidjeti dio 4.4).
English: Increasing the infusion time from 5 to 15 minutes caused a 30% decrease in zoledronic acid concentration at the end of the infusion, but had no effect on the area under the plasma concentration versus time curve.
Croatian: Produljenje vremena infuzije s 5 na 15 minuta uzrokovalo je 30%-tno smanjenje koncentracije zoledronatne kiseline na kraju infuzije, no nije imalo učinka na područje ispod krivulje ovisnosti koncentracije u plazmi naspram vremena.
English: Other disturbances of mineral metabolism must also be effectively treated (e.g. diminished parathyroid reserve, intestinal calcium malabsorption).
Croatian: Ostali poremećaji metabolizma minerala se također moraju učinkovito liječiti (npr. smanjenje zalihe paratireoidnih žlijezda, intestinalna malapsorpcija kalcija).
English: Bone biopsy results showed bone of normal quality with no evidence of impaired bone remodelling and no evidence of mineralisation defects.
Croatian: Rezultati biopsije kosti pokazali su kost normalne kakvoće bez dokaza oštećenog remodeliranja kosti, kao i bez dokaza defekata mineralizacije.
English: The efficacy of one infusion of 5 mg zoledronic acid versus daily doses of 30 mg risedronate for 2 months was demonstrated in two 6-month comparative trials.
Croatian: Djelotvornost jedne infuzije od 5 mg zoledronatne kiseline naspram dnevnih doza od 30 mg risedronata kroz 2 mjeseca bila je pokazana u dva 6-mjesečna usporedna ispitivanja.
English: If you are under dental treatment or are due to undergo dental surgery (e.g. tooth extractions), inform your doctor about your dental treatment and tell your dentist that you are being treated with Aclasta.
Croatian: Ako ste uslijed liječenja kod zubara ili ako idete na kirurški zahvat zuba (npr. vađenje zuba), obavijestite svog liječnika o Vašem liječenju kod zubara i obavijestite svog zubara da se liječite Aclastom.
English: Table 2 Summary of vertebral fracture efficacy at 12, 24 and 36 months
Croatian: Tablica 2 Sažetak učinkovitosti s obzirom na vertebralne prijelome u 12., 24. i 36. mjesecu Ishod
English: - if you have hypocalcaemia (this means that the levels of calcium in your blood are too low).
Croatian: (naveden u dijelu 6.). - ako imate hipokalcijemiju (to znači da su razine kalcija u Vašoj krvi preniske).
English: - Aclasta 5 mg solution for infusion is ready for use.
Croatian: - Aclasta 5 mg otopina za infuziju je spremna za uporabu.
English: It is important for your doctor to know all the medicines you are taking, especially if you are taking any medicines known to be harmful to your kidneys (e.g. aminoglycosides) or diuretics (“waterpills”) that may cause dehydration.
Croatian: Važno je da Vaš liječnik zna za sve lijekove koje uzimate, naročito ako uzimate lijekove za koje je poznato da štetno djeluju na Vaše bubrege (npr. aminoglikozidi) ili ako uzimate diuretike („tablete za mokrenje“) koji mogu uzrokovati dehidraciju.
English: Decreased circulating levels of sex hormones, mainly oestrogens converted from androgens, also play a role in the more gradual bone loss observed in men.
Croatian: Sniženje razine spolnih hormona u cirkulaciji, prvenstveno estrogena koji su nastali od androgena, također ima ulogu u postupnijem gubitku kosti opaženom u muškaraca.
English: The most commonly reported adverse reactions after infusion of zoledronic acid were arthralgia (28%), pyrexia (22%), vomiting (22%), headache (22%), nausea (17%), myalgia (17%), pain (17%), diarrhoea (11%) and hypocalcaemia (11%).
Croatian: Najčešće prijavljene nuspojave nakon infuzije zoledronatne kiseline bile su artralgija (28%), pireksija (22%), povraćanje (22%), glavobolja (22%), mučnina (17%), mijalgija (17%), bol (17%), proljev (11%) i hipokalcemija (11%).
English: Osteoporosis is a disease that involves the thinning and weakening of the bones and is common in women after the menopause, but can also occur in men.
Croatian: Osteoporoza je bolest koja uključuje stanjivanje i slabljenje kostiju, a često se javlja kod žena nakon menopauze, ali se također može pojaviti u muškaraca.
English: The selective action of bisphosphonates on bone is based on their high affinity for mineralised bone.
Croatian: Selektivno djelovanje bisfosfonata na kost temelji se na njihovom visokom afinitetu prema mineraliziranoj kosti.
English: Aclasta demonstrated a consistent effect over 3 years, resulting in a 41% reduction in the risk of hip fractures (95% CI, 17% to 58%).
Croatian: Aclasta je pokazala održani učinak tijekom 3 godine što je rezultiralo 41%-tnim smanjenjem rizika za prijelome kuka (95% CI, 17% do 58%).
English: Re-treatment of Paget's disease: After initial treatment with Aclasta in Paget's disease, an extended remission period is observed in responding patients.
Croatian: Ponovno liječenje Pagetove bolesti: Nakon početnog liječenja Aclastom u slučaju Pagetove bolesti, zapažen je produljen period remisije u bolesnika koji su odgovorili na liječenje.
English: In a large clinical trial in 7,736 patients, osteonecrosis of the jaw has been reported in one patient treated with Aclasta and one patient treated with placebo.
Croatian: U velikom kliničkom ispitivanju s 7736 bolesnika, osteonekroza čeljusti prijavljena je u jednog bolesnika liječenog Aclastom i u jednog bolesnika koji je primao placebo.
English: For the treatment of Paget's disease, Aclasta should be prescribed only by physicians with experience in the treatment of Paget's disease of the bone.
Croatian: Za liječenje Pagetove bolesti, Aclastu smiju propisivati samo liječnici koji imaju iskustva u liječenju Pagetove bolesti kosti.
English: Concomitant osteoporosis therapy included: calcitonin, raloxifene, tamoxifen, hormone replacement therapy, tibolone; but excluded other bisphosphonates.
Croatian: Istodobna terapija osteoporoze uključivala je: kalcitonin, raloksifen, tamoksifen, hormonsku nadomjesnu terapiju, tibolon; međutim, isključeni su ostali bisfosfonati.
English: The incidence of post-dose symptoms occurring within the first three days after administration of Aclasta can be reduced with the administration of paracetamol or ibuprofen shortly following Aclasta administration.
Croatian: Incidencija simptoma nakon doze koji se javljaju u roku od prva tri dana nakon primjene Aclaste može se smanjiti primjenom paracetamola ili ibuprofena ubrzo nakon primjene Aclaste.
English: Tell your doctor and dentist immediately if you experience such symptoms while being treated with Aclasta or after stopping treatment.
Croatian: Odmah se obratite svom liječniku i zubaru ako primijetite takve simptome za vrijeme liječenja Aclastom ili nakon prestanka liječenja.
English: • Transient increase in serum creatinine may be greater in patients with underlying impaired renal function.
Croatian: • Prolazni porast kreatinina u serumu može biti veći u bolesnika s podležećim oštećenjem funkcije bubrega.
English: Your doctor may advise you to take calcium and vitamin D supplements (e.g. tablets) for at least the first ten days after being given Aclasta.
Croatian: Liječnik Vam može savjetovati da uzimate nadomjestke kalcija i vitamina D (na primjer tablete) najmanje tijekom prvih deset dana nakon primjene Aclaste.
English: The incidence of these reactions decreased markedly with subsequent annual doses of Aclasta.
Croatian: Incidencija tih reakcija značajno se smanjila sa sljedećim godišnjim dozama Aclaste.
English: Due to the rapid onset of effect of zoledronic acid on bone turnover, transient hypocalcaemia, sometimes symptomatic, may develop and is usually maximal within the first 10 days after infusion of Aclasta (see section 4.8).
Croatian: Zbog brzog nastupa učinka zoledronatne kiseline na pregradnju kosti, može se razviti prolazna hipokalcijemija, koja je katkada simptomatska, a obično je najjača unutar prvih 10 dana nakon infuzije Aclaste (vidjeti dio 4.8).
English: - Hypersensitivity to the active substance, to any bisphosphonates or to any of the excipients listed in section 6.1.
Croatian: - Preosjetljivost na djelatnu tvar, na bilo koje bisfosfonate ili neku od pomoćnih tvari navedenih u dijelu 6.1.
English: It is supplied in packs containing one bottle as unit pack, or in multipacks comprising five packs, each containing one bottle.
Croatian: Dostupna je u pakiranjima koja sadrže jednu bočicu kao jedinično pakiranje, ili u višestrukim pakiranjima koja se sastoje od pet pakiranja, od kojih svako sadrži jednu bočicu.
English: Patients being treated with Aclasta should not be treated with such products or any other bisphosphonate concomitantly, since the combined effects of these agents are unknown.
Croatian: Bolesnici koji se liječe Aclastom ne smiju istodobno uzimati takve lijekove ili bilo koji drugi bisfosfonat, budući da kombinirani učinci tih tvari nisu poznati.
English: Longer-term repeat administration at cumulative exposures sufficiently exceeding the maximum intended human exposure produced toxicological effects in other organs, including the gastrointestinal tract and liver, and at the site of intravenous administration.
Croatian: Dugotrajna ponovljena primjena pri kumulativnim izloženostima koje su dovoljno prekoračivale najveću planiranu izloženost u ljudi, izazvala je toksikološke učinke na drugim organima, uključujući gastrointestinalni trakt i jetru, kao i na mjestu intravenske primjene.
English: - Keep this medicine out of the sight and reach of children.
Croatian: Ovaj lijek čuvajte izvan pogleda i dohvata djece.
English: The majority of the side effects, such as fever and chills, pain in the muscles or joints, and headache, occur within the first three days following the dose of Aclasta.
Croatian: Većina nuspojava, poput vrućice i zimice, bolova u mišićima ili zglobovima te glavobolje, javlja se unutar prva tri dana nakon primjene doze Aclaste.
English: 100 ml solution in a transparent plastic (cycloolefinic polymer) bottle closed with a fluoro-polymer coated bromobutyl rubber stopper and an aluminium/polypropylene cap with a flip component.
Croatian: 100 ml otopine u prozirnoj plastičnoj (cikloolefinski polimer) bočici zatvorenoj čepom od bromobutilne gume obložene fluoropolimerom te aluminij/polipropilenskom kapicom s preklopnim dijelom.
English: Your doctor may ask you to undergo a dental examination before you start treatment with Aclasta.
Croatian: Vaš liječnik može predložiti da obavite pregled kod zubara prije nego počnete liječenje Aclastom.
English: Aclasta is also used in patients who have recently broken their hip in a minor trauma such as a fall and therefore are at risk of subsequent bone breaks.
Croatian: Aclasta se također koristi u bolesnika koji su nedavno slomili svoj kuk pri maloj traumi kao što je pad pa imaju stoga povećan rizik za sljedeće lomove kosti.
English: Not known** Hypersensitivity reactions including rare cases of bronchospasm, urticaria and angioedema, and very rare cases of anaphylactic reaction/shock
Croatian: Nepoznato** Reakcije preosjetljivosti uključujući rijetke slučajeve bronhospazma, urtikarije i angioedema, i vrlo rijetke slučajeve anafilaktičke reakcije/šoka
English: No statistically significant differences in total body bone mineral content were observed between patients treated with zoledronic acid versus placebo at 6 or 12 months.
Croatian: Nisu zapažene statistički značajne razlike u ukupnom mineralnom sadržaju kostiju u tijelu između bolesnika liječenih zoledronatnom kiselinom i placeba u 6. ili 12. mjesecu.
English: Aclasta must not be mixed or given intravenously with any other medicinal products.
Croatian: Aclasta se ne smije miješati niti primijeniti intravenski s bilo kojim drugim lijekovima.
English: 1 bottle of 100 ml Component of a multipack.
Croatian: 1 bočica od 100 ml Sastavni dio višestrukog pakiranja.
English: Aclasta is supplied in packs containing one bottle as unit pack, or in multipacks comprising five packs, each containing one bottle.
Croatian: Aclasta se isporučuje u pakiranjima koja sadrže jednu bočicu kao jedinično pakiranje ili u višestrukim pakiranjima koja se sastoje od pet pakiranja, od kojih svako sadrži jednu bočicu.
English: The study was not powered to show a reduction in clinical fractures in men; the incidence of clinical fractures was 7.5% in men treated with Aclasta versus 8.7% for placebo.
Croatian: Ispitivanje nije bilo pokrenuto da pokaže smanjenje kliničkih prijeloma u muškaraca; incidencija kliničkih prijeloma bila je 7,5% u muškaraca liječenih Aclastom naspram 8,7% za placebo.
English: Dystocia was observed at the lowest dose (0.01 mg/kg body weight) tested in rats.
Croatian: Distocija je zapažena uz najnižu dozu (0,01 mg/kg tjelesne težine) koja je ispitivana u štakora.
English: Re-treatment consists of an additional intravenous infusion of 5 mg Aclasta after an interval of one year or longer from initial treatment in patients who have relapsed.
Croatian: Ponovno liječenje sastoji se od dodatne intravenske infuzije Aclaste u dozi od 5 mg nakon intervala od jedne godine ili dulje od početnog liječenja u bolesnika kod kojih je došlo do relapsa.
English: In patients with Paget's disease, symptoms due to low blood calcium, such as muscle spasms, or numbness, or a tingling sensation especially in the area around the mouth have been reported.
Croatian: Kod bolesnika s Pagetovom bolešću, zabilježeni su simptomi zbog niske razine kalcija u krvi, kao što su grčevi mišića, ili utrnutost, ili osjećaj trnaca osobito u području oko usta.
English: Very common Pyrexia Common
Croatian: Vrlo često Pireksija Često
English: The percentage of patients who experienced adverse reactions was lower in a smaller study (19.5%, 10.4%, 10.7% after the first, second and third infusion, respectively), where prophylaxis against adverse reactions was used.
Croatian: Postotak bolesnika koji su imali nuspojave bio je niži u manjem ispitivanju (19,5%, 10,4%, 10,7% nakon prve, druge, odnosno treće infuzije) kad je bila korištena profilaksa protiv nuspojava.
English: Intravenously administered zoledronic acid is eliminated by a triphasic process: rapid biphasic disappearance from the systemic circulation, with half-lives of t½ 0.24 and t½ 1.87 hours, followed by a long elimination phase with a terminal elimination half-life of t½ 146 hours.
Croatian: Intravenski primijenjena zoledronatna kiselina eliminira se trifaznim procesom: brzi bifazni nestanak iz sistemske cirkulacije, uz poluvijekove t½α od 0,24 i t½β od 1,87 sati, nakon čega slijedi dugačka faza eliminacije s terminalnim poluvijekom eliminacije t½γ od 146 sati.
English: There was no progressive reduction of bone turnover markers with repeated annual dosing.
Croatian: Nije opaženo progresivno smanjenje markera koštane pregradnje s ponovljenim godišnjim doziranjem.
English: Microcomputed tomography (μCT) analysis demonstrated increased trabecular bone volume and preservation of trabecular bone architecture in patients treated with Aclasta compared to placebo.
Croatian: Analiza mikrokompjuteriziranom tomografijom (μCT) pokazala je povećani volumen trabekularne kosti i očuvanje trabekularne arhitekture kosti u bolesnica liječenih Aclastom, u usporedbi s placebom.
English: Studies in animals with zoledronic acid have shown reproductive toxicological effects including malformations (see section 5.3).
Croatian: Ispitivanja na životinjama sa zoledronatnom kiselinom pokazala su reproduktivne toksikološke učinke, uključujući malformacije (vidjeti dio 5.3).
English: • in adult men at increased risk of fracture, including those with a recent low-trauma hip fracture.
Croatian: • kod odraslih muškaraca s povećanim rizikom za prijelome, uključujući one koji su nedavno imali prijelom kuka nakon manje traume.