FrancophonIA/ELRC3.0 huggingface dataset:
English: The tablets contain lactose monohydrate and therefore should not be administered to patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malabsorption.
Maltese: Il-pilloli fihom lattosju monohydrate u għalhekk m'għandhomx jingħataw lill-pazjenti bi problemi ereditarji rari ta' intolleranza għall-galaktosju, nuqqas totali ta' lactase jew malassorbiment talglukosju-galaktosju.
English: common common common increased lactic dehydrogenase uncommon decrease in sodium serum concentrations very rare very rare alanine aminotransferase increase10
Maltese: Komuni żieda ta' lactic dehydrogenase mhux komuni tnaqqis fil-konċentrazzjoni tas-sodju fis-serum rari ħafna rari ħafna żieda f'alanine aminotransferase10
English: Elderly Steady state pharmacokinetics are similar in patients age 65 and over and young subjects.
Maltese: Il-farmakokinetika fi stat stabbli ta' pazjenti b'eta' ta' 65 sena jew aktar hija simili għal dik ta'
English: Ear and labyrinth disorders vertigo uncommon
Maltese: Disturbi fil-widnejn u fis-sistema labirintika vertigo mhux komuni
English: Hepatobiliary disorders6 hepatitis very rare very rare impairment of liver function (with cholestasis and jaundice)
Maltese: epatatite rari ħafna rari ħafna indeboliment tal-funzjoni tal-fwied (b'kolestasi u suffejra)
English: Treatment with Tandemact requires regular monitoring of glycaemic control.
Maltese: Kura b'Tandemact tinħtieġ sorveljanza regolari tal-kontroll gliċemiku.
English: Tandemact is contra-indicated during breast-feeding (see section 4.3).
Maltese: Tandemact huwa kontra-indikat waqt it-tqala (ara sezzjoni 4.3).
English: Hydroxypropylcellulose
Maltese: tritoqualine fluconazole
English: The reports of oedema were generally mild to moderate and usually did not require discontinuation of treatment.
Maltese: Ir-rapporti ta' edema ġeneralment kienu ħfief għal moderati u normalment ma kienux jinħtieġu l-waqfien tal-kura.
English: Each tablet contains approximately 214 mg lactose monohydrate (see section 4.4).
Maltese: Kull pillola fiha madwar 214 mg lattosju monohydrate (ara sezzjoni 4.4).
English: Each Tandemact 45 mg/4 mg tablet contains 45 mg pioglitazone (as hydrochloride) and 4 mg glimepiride.
Maltese: Kull pillola Tandemact 45 mg/4 mg fiha 45 mg pioglitazone (bħala hydrochloride) u 4 mg glimepiride.
English: - anabolic steroids (supporting muscle build up) or male sex hormone replacement therapy - fluoxetine, MAO-inhibitors (to treat depression) - angiotensin-converting enzyme (ACE) inhibitors, sympatholytics, disopyramide, pentoxifylline,
Maltese: - fluoxetine, inibituri tal-MAO (biex jittrattaw id-dipressjoni) - inibituri tal- enzima li tikkonverti lil angiotensin (ACE, angiotensin-converting enzyme),
English: To be eligible patients had to have had one or more of the following: myocardial infarction, stroke, percutaneous cardiac intervention or coronary artery bypass graft, acute coronary syndrome, coronary artery disease, or peripheral arterial obstructive disease.
Maltese: Biex ikunu eliġibbli, pazjenti kellu jkollhom wieħed jew aktar minn dawn li ġejjin: infart mijokardijaku, puplesijja, intervent kardijaku perkutanju jew bypass graft tal-arterja koronarja, sindrome koronarju akut, marda ta' l-arterji koronarji, jew marda ostruttiva ta' l-arterji periferali.
English: Renal elimination of the two metabolites was impaired.
Maltese: Eliminazzjoni renali taż-żewġ metaboliti kienet imnaqqsa.
English: 9 In active comparator controlled trials mean weight increase with pioglitazone given as monotherapy was 2 - 3 kg over one year.
Maltese: 9Fi provi attivi kkontrollati ta' paragun, iż-żieda medja fil-piż bi pioglitazone mogħti bħala monoterapija kienet ta' 2 - 3 kg fuq medda ta' sena.
English: Pioglitazone did not cause statistically significant increases in LDL-cholesterol levels compared with placebo, whilst reductions were observed with metformin and gliclazide.
Maltese: Pioglitazone ma wassalx għall-żieda statistikament sinifikanti fil-livell ta' LDL cholesterol meta mqabbel mal-plaċebo, filwaqt li tnaqqis kien osservat b'metformin u gliclazide.
English: 8 Oedema was reported in 6-9% of patients treated with pioglitazone over one year in controlled clinical trials.
Maltese: 8Edema kienet irrappurtata f'6- 9% tal-pazjenti kkurati b'pioglitazone fuq medda ta' sena fi provi kliniċi kkontrollati.
English: Tandemact 45 mg/4 mg tablets
Maltese: Pilloli Tandemact 45 mg/4 mg
English: EU/1/06/366/011 14 tablets EU/1/06/366/012 28 tablets EU/1/06/366/013 30 tablets EU/1/06/366/014 50 tablets EU/1/06/366/015 90 tablets EU/1/06/366/016 98 tablets
Maltese: EU/1/06/366/011 14-il pillola EU/1/06/366/012 28 pillola EU/1/06/366/013 30 pillola EU/1/06/366/014 50 pillola EU/1/06/366/015 90 pillola EU/1/06/366/016 98 pillola
English: The extrapancreatic effects are for example an improvement of the sensitivity of the peripheral tissue for insulin and a decrease of the insulin uptake by the liver.
Maltese: L-effetti extrapankrejatiċi huma per eżempju titjib fis-sensittività tat-tessuti periferali għall-insulina u tnaqqis fit-tneħħija ta' l-insulina mill-fwied.
English: EU/1/06/366/017 14 tablets EU/1/06/366/018 28 tablets EU/1/06/366/019 30 tablets EU/1/06/366/020 50 tablets EU/1/06/366/021 90 tablets EU/1/06/366/022 98 tablets
Maltese: EU/1/06/366/017 14-il pillola EU/1/06/366/018 28 pillola EU/1/06/366/019 30 pillola EU/1/06/366/020 50 pillola EU/1/06/366/021 90 pillola EU/1/06/366/022 98 pillola
English: Symptoms may not be present for up to 24 hours after ingestion.
Maltese: Is-sintomi jistgħu ma jidrhux sa 24 siegħa wara t-teħid.
English: Each Tandemact 30 mg/2 mg tablet contains 30 mg pioglitazone (as hydrochloride) and 2 mg glimepiride.
Maltese: Kull pillola Tandemact 30 mg/2 mg fiha 30 mg pioglitazone (bħala hydrochloride) u 2 mg glimepiride.
English: Maximum serum concentrations (Cmax) are reached approximately 2.5 hours after oral intake (mean 0.3 µg/mL during multiple dosing of 4 mg daily).
Maltese: Konċentrazzjonijiet massimi fis-serum (Cmax) jintlaħqu f'madwar 2.5 sigħat wara t-teħid orali (medja ta' 0.3 µg/mL waqt dożaġġ multiplu ta' 4 mg kuljum).
English: Frequency of adverse reactions Pioglitazone Glimepiride Tandemact
Maltese: - Is-sustanzi attivi huma pioglitazone u glimepiride.
English: Since glimepiride belongs to the chemical class of sulfonylurea medicinal products, caution should be used in patients with G6PD-deficiency and a non-sulfonylurea alternative should be considered.
Maltese: Minħabba li glimepiride jagħmel parti mill-klassi kimika ta'prodotti mediċinali minn sulfonylurea, ġħandha tittieħed kawtela f'pazjenti b'nuqqas ta' G6PD u għandha tiġi kkunsidrata alternattiva li mhix sulfonylurea.
English: Adverse reactions reported in double-blind studies and post marketing experience are listed below as MedDRA preferred term by system organ class and absolute frequency.
Maltese: Reazzjonijiet avversi fi studji double-blind u esperjenzi wara t-tqeghid fis-suq huma mniżżla hawn taħt bit-terminu ppreferut tal-MedDRA skont il-klassi tas-sistemi u tal-organi u l-frekwenza assoluta.
English: The following statements reflect the information available on the individual active substances (pioglitazone and glimepiride).
Maltese: Id-dikjarazzjonijiet li ġejjin jirriflettu l-informazzjoni disponibbli dwar is-sustanzi attivi individwali (pioglitazone u glimepiride).
English: The hypoglycaemia may in general be accompanied by neurological symptoms like restlessness, tremor, visual disturbances, coordination problems, sleepiness, coma and convulsions.
Maltese: L-ipogliċemija tista' ħafna drabi tkun akkompanjata minn sintomi newroloġiċi bħal irrekwitezza, rogħda, disturbi fil-vista, problemi ta' koordinazzjoni, ngħas, koma u konvulżjonijiet.
English: Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu
Maltese: Informazzjoni ddettaljata dwar din il-mediċina tinsab fuq is-sit elettroniku tal-Aġenzija Ewropea għall-Mediċini: http://www.ema.europa.eu.
English: - if you have cysts on your ovaries (polycystic ovary syndrome).
Maltese: - jekk għandek ċesti fl-ovarji (sindromu tal-ovarji poliċistiċi).
English: NAME OF THE MEDICINAL PRODUCT Tandemact 45 mg/4 mg tablets pioglitazone/glimepiride
Maltese: Pilloli Tandemact 45 mg/4 mg pioglitazone/glimepiride
English: Delpharm Novara S.r.l.
Maltese: Sweeteners arifiċjali m'għandhom l-ebda effett.
English: EU/1/06/366/005 14 tablets EU/1/06/366/006 28 tablets EU/1/06/366/007 30 tablets EU/1/06/366/008 50 tablets EU/1/06/366/009 90 tablets EU/1/06/366/010 98 tablets
Maltese: EU/1/06/366/005 14-il pillola EU/1/06/366/006 28 pillola EU/1/06/366/007 30 pillola EU/1/06/366/008 50 pillola EU/1/06/366/009 90 pillola EU/1/06/366/010 98 pillola
English: Pregnancy
Maltese: Antagonisti
English: Tandemact should be discontinued if any deterioration in cardiac state occurs.
Maltese: - Insuffiċjenza kardijaka jew passat ta' insuffiċjenza kardijaka (NYHA stadju I sa
English: Pioglitazone was devoid of genotoxic potential in a comprehensive battery of in vivo and in vitro genotoxicity assays.
Maltese: Pioglitazone ma kellux potenzjal ta' effett tossiku fuq il-ġeni f'sensiela kompluta ta' analiżi ġenotossika in vivo u in vitro.
English: coumarin derivatives such as warfarin (to treat heart or blood problems) - allopurinol, probenecid, sulfinpyrazone (to treat gout) - cyclophosphamide, ifosfamide, trofosfamide (to treat cancer) - fenfluramine (to reduce weight) - tritoqualine (to treat allergies)
Maltese: sympatholytics, disopyramide, pentoxifylline, derivativi tal-coumarin bħal warfarina (biex jittrattaw problemi tal-qalb jew fid-demm) - allopurinol, probenecid, sulfinpyrazone (biex jittrattaw il-gotta) - cyclophosphamide, ifosfamide, trofosfamide (biex jittrattaw il-kanċer) - fenfluramine (biex tnaqqas il-piż) - tritoqualine (biex tittratta l-allerġiji)
English: A clinical trial of pioglitazone vs. gliclazide as monotherapy was extended to two years in order to assess time to treatment failure (defined as appearance of HbA1c ≥ 8.0% after the first six months of therapy).
Maltese: Prova klinika ta' pioglitazone vs. gliclazide bħala monoterapija ġiet estiża għal sentejn sabiex jiġi studjat il-ħin sal-falliment tal-kura (definit bħala d-dehra ta' HbA1c ≥ 8.0% wara l-ewwel sitt xhur ta' terapija).
English: Infections and infestations upper respiratory tract infection common common sinusitis uncommon uncommon
Maltese: Infezzjonijiet u infestazzjonijiet infezzjoni fil-passaġġ respiratorju ta' fuq komuni
English: Suomi/Finland Takeda Oy
Maltese: Suomi/Finland
English: This can lead to a risk of hypoglycaemia (low blood sugar): - gemfibrozil and fibrates (to lower high cholesterol level) - insulin, metformin or other medicines to treat diabetes mellitus - phenylbutazone, azapropazone, oxyphenbutazone, aspirin-like medicines (to treat pain and inflammation) - long acting sulphonamides, tetracyclines, chloramphenicol, fluconazole, miconazole,
Maltese: Dan jista jwassal ghar-riskju ta' ipogliċemija (livell baxx taz-zokkor fid-demm): - gemfibrozil u fibrates (użati biex ibaxxu l-kolesterol) - insulina, metformin jew mediċini ohra biex jittrattaw id-dijabete mellitus - phenylbutazone, azopropazone, oxyphenbutazone, mediċini bħall-aspirina (biex jittrattaw uġigħ jew infjammazzjoni) - sulfonamides li jaġixxu fit-tul, tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin (biex jittrattaw infezzjonijiet batterjali jew fungali) - steroids anaboliċi (għall-appogg fil-build up tal-muskoli) jew terapija ormonali biex tisostitwixxi l-ormoni maskili
English: Tandemact should not be used in patients with severe renal function disorders (creatinine clearance < 30 ml/min, see section 4.3).
Maltese: - Disturbi severi fil-funzjoni renali (tnehħija ta' kreatinina < 30 ml/min) - Tqala - Treddigħ (ara sezzjoni 4.6)
English: How to store Tandemact
Maltese: X'fih Tandemact
English: Neoplasms benign, malignant and unspecified (including cysts and polyps) bladder cancer uncommon uncommon
Maltese: Neoplażmi bennini, malanni u dawk mhux speċifikati (inklużi ċesti u polipi)
English: Very rare (may affect up to 1 in 10,000 people) - liver disease
Maltese: Rari ħafna (jistgħu jaffettwaw sa persuna waħda minn kull 10,000)
English: HOMA analysis shows that pioglitazone improves beta cell function as well as increasing insulin sensitivity.
Maltese: HOMA turi li pioglitazone itejjeb il-funzjoni taċ-ċellola beta kif ukoll iżid is-sensittività għall-insulina.
English: Each Tandemact 30 mg/4 mg tablet contains 30 mg pioglitazone (as hydrochloride) and 4 mg glimepiride.
Maltese: Kull pillola Tandemact 30 mg/4 mg fiha 30 mg pioglitazone (bħala hydrochloride) u 4 mg glimepiride.
English: There have been rare reports of elevated liver enzymes and hepatocellular dysfunction during post-marketing experience with pioglitazone and glimepiride (see section 4.8).
Maltese: Tibdiliet rari fl-ematoloġija kienu osservati b'kura b'glimepiride (ara sezzjoni 4.8).
English: Tandemact 45 mg/4 mg tablets White to off-white, round, flat and debossed ‘4833 G' on one face and ‘45/4' on the other.
Maltese: - Tandemact 45 mg/4 mg huma pilloli bojod għal abjad maħmuġ, tondi, ċatti u mmarkati b'‘4833 G' fuq naħa u b'‘45/4' fuq in-naħa l-oħra.
English: Start the administration of glucose as soon as possible, if necessary by a bolus intravenous injection of 50 ml of a 50% solution, followed by an infusion of a 10% solution with strict monitoring of blood glucose.
Maltese: jekk hemm bżonn b'injezzjoni bolus ġol-vina ta' 50 ml ta' soluzzjoni ta' 50%, segwita minn infużjoni ta' soluzzjoni ta' 10% b'sorveljanza stretta ta' glukosju fid-demm.
English: General disorders and administration site conditions oedema8
Maltese: Disturbi ġenerali u kondizzjonijiet ta' mnejn jingħata edima8
English: NAME OF THE MEDICINAL PRODUCT Tandemact 30 mg/2 mg tablets pioglitazone/glimepiride
Maltese: Pilloli Tandemact 30 mg/2 mg pioglitazone/glimepiride
English: INFORMATION IN BRAILLE Tandemact 45 mg/4 mg
Maltese: Tandemact 45 mg/4 mg
English: Eye disorders visual disturbance4
Maltese: Disturbi fl-għajnejn disturbi viżwali 4
English: Tandemact 30 mg/4 mg tablets
Maltese: Pilloli Tandemact 30 mg/4 mg
English: Tandemact 30 mg/2 mg tablets White to off-white, round, convex and debossed ‘4833 G' on one face and ‘30/2' on the other.
Maltese: - Tandemact 30 mg/2 mg huma pilloli bojod għal abjad maħmuġ, tondi, konvessi u mmarkati b'‘4833 G' fuq naħa u b'‘30/2' fuq in-naħa l-oħra.
English: Interactions with substances metabolised by these enzymes, e.g. oral contraceptives, cyclosporin, calcium channel blockers, and HMGCoA reductase inhibitors are not to be expected.
Maltese: e.ż. kontraċettivi mill-ħalq, cyclosporin, imblokkaturi tal-kanali tal-kalċju, u inibituri ta' HMGCoA
English: Pioglitazone appears to act via activation of specific nuclear receptors (peroxisome proliferator activated receptor gamma) leading to increased insulin sensitivity of liver, fat and skeletal muscle cells in animals.
Maltese: Pioglitazone jidher li jaħdem permezz ta' attivazzjoni ta' riċetturi nuklejari speċifiċi (peroxisome proliferator activated receptor gamma) li twassal għal żieda fis-sensittività għall-insulina tal-fwied, xaħam u ċelloli tal-muskoli skeletrali fl-annimali.
English: Gastrointestinal disorders5 flatulence common vomiting very rare very rare diarrhoea very rare very rare nausea very rare very rare abdominal pain very rare very rare abdominal pressure very rare very rare
Maltese: Komuni rimettar rari ħafna rari ħafna dijarea rari ħafna rari ħafna dardir rari ħafna rari ħafna uġigħ addominali rari ħafna rari ħafna pressjoni addominali rari ħafna rari ħafna sensazzjoni ta' mili fl-istonku rari ħafna rari ħafna
English: In PROactive, a cardiovascular outcome study, 5,238 patients with type 2 diabetes mellitus and pre-existing major macrovascular disease were randomised to pioglitazone or placebo in addition to existing antidiabetic and cardiovascular therapy, for up to 3.5 years.
Maltese: Fi PROactive, studju dwar l-effett kardjovaskulari, 5,238 pazjent b'dijabete mellitus tat-tip 2 u b'marda makrovaskulari maġġuri eżistenti minn qabel kienu randomised għal pioglitazone jew plaċebo flimkien ma' terapija antidijabetika u kardjovaskulari eżistenti, sa 3.5 snin.
English: Distribution The estimated volume of distribution in humans is 0.25 L/kg.
Maltese: Il-volum stmat ta' distribuzzjoni fil-bnedmin huwa ta' 0.25
English: In clinical trials of up to two years duration, pioglitazone reduced total plasma triglycerides and free fatty acids, and increased HDL-cholesterol levels, compared with placebo, metformin or gliclazide.
Maltese: Fi provi kliniċi li damu sa sentejn, pioglitazone naqqas it-triġliċeridi totali fil-plażma u l-fatty acids ħielsa, u żied l-livelli ta' HDL kolesterol, meta mqabbel mal-plaċebo, metformin jew gliclazide.
English: Co-administration of pioglitazone with rifampicin (an inducer of cytochrome P450 2C8) is reported to result in a 54% decrease in AUC of pioglitazone.
Maltese: Ħuwa rrappurtat li l-għotja ta' pioglitazone flimkien ma' rifampicin (induttur taċ-ċitokromju P450 2C8) twassal għal tnaqqis ta' 54% fl-AUC ta' pioglitazone.
English: Do not use this medicine after the expiry date which is stated on the carton and the blister after “EXP”.
Maltese: Tużax din il-mediċina wara d-data ta' meta tiskadi li tidher fuq il-kartuna u fuq il-folja wara “EXP”.
English: Each tablet contains 45 mg of pioglitazone (as hydrochloride) and 4 mg of glimepiride.
Maltese: Kull pillola fiha 45 mg pioglitazone (bħala hydrochloride) u 4 mg glimepiride.
English: NAME OF THE MEDICINAL PRODUCT Tandemact 30 mg/4 mg tablets pioglitazone/glimepiride
Maltese: Pilloli Tandemact 30 mg/4 mg pioglitazone/glimepiride
English: EU/1/06/366/005 EU/1/06/366/006 EU/1/06/366/007 EU/1/06/366/008 EU/1/06/366/009 EU/1/06/366/010 EU/1/06/366/011 EU/1/06/366/012 EU/1/06/366/013 EU/1/06/366/014 EU/1/06/366/015 EU/1/06/366/016 EU/1/06/366/017
Maltese: EU/1/06/366/005 EU/1/06/366/006 EU/1/06/366/007 EU/1/06/366/008 EU/1/06/366/009 EU/1/06/366/010
English: Hypoglycaemic reactions mostly occur immediately due to the sulphonylurea component of Tandemact.
Maltese: Ġeneralment, ossevazzjoni fi sptar hija rakkomandata.
English: INFORMATION IN BRAILLE Tandemact 30 mg/2 mg
Maltese: Tandemact 30 mg/2 mg
English: oestrogens and progestagens, saluretics, thiazide diuretics, thyroid stimulating agents, glucocorticoids, phenothiazine derivatives, chlorpromazine, adrenaline and sympathicomimetics, nicotinic acid (high doses) and nicotinic acid derivatives, laxatives (long-term use), phenytoin, diazoxide, glucagon, barbiturates and rifampicin.
Maltese: aġenti li jistimolaw it-tirojde, glukokortikojdi, derivati minn phenothiazine, chlorpromazine, adrenalina u sympathicomimetics,
English: Rare (may affect up to 1 in 1,000 people) - noticeable changes in blood
Maltese: Rari (jistgħu jaffettwaw sa persuna waħda minn kull 1,000)
English: Tandemact 30 mg/4 mg tablets White to off-white, round, convex and debossed ‘4833 G' on one face and ‘30/4' on the other.
Maltese: - Tandemact 30 mg/4 mg huma pilloli bojod għal abjad maħmuġ, tondi, konvessi u mmarkati b'‘4833 G' fuq naħa u b'‘30/4' fuq in-naħa l-oħra.
English: Investigations weight increased9
Maltese: Investigazzjonijiet żieda fil-piż 9
English: INFORMATION IN BRAILLE Tandemact 30 mg/4 mg
Maltese: Tandemact 30 mg/4 mg
English: No animal studies have been conducted with the combined products of Tandemact.
Maltese: Ma sarux studji fuq l-annimali bil-prodotti kombinati ta' Tandemact.
English: NAME OF THE MARKETING AUTHORISATION HOLDER Takeda (logo)
Maltese: Takeda (logo)
English: Each tablet contains 30 mg of pioglitazone (as hydrochloride) and 2 mg of glimepiride.
Maltese: Kull pillola fiha 30 mg pioglitazone (bħala hydrochloride) u 2 mg glimepiride.
English: The following medicines can increase or decrease the blood sugar lowering effect of Tandemact: - H2 antagonists (to treat stomach ulcers) - beta-blockers, clonidine, guanethidine and reserpine (to treat high blood pressure or heart failure).
Maltese: H2 (biex jittrattaw l-ulceri fl-istonku) - imblokkaturi tar-ricetturi beta, clonidine, guanethidine u reserpine (biex jittrattaw pressjoni gholja fid-demm jew insufficjenza tal-qalb).
English: In controlled clinical trials the incidence of reports of heart failure with pioglitazone treatment was the same as in placebo, metformin and sulphonylurea treatment groups, but was increased when used in combination therapy with insulin.
Maltese: Fi provi kliniċi kkontrollati l-inċidenza ta' rapporti ta' insuffiċjenza tal-qalb b'kura ta' pioglitazone kienet l-istess bħall-gruppi ta' kura bil-plaċebo, metformin u sulphonylurea, iżda kienet miżjuda meta wżata f'terapija kombinata ma' insulina.
English: Metabolism and nutrition disorders hypoglycaemia uncommon appetite increased uncommon
Maltese: Disturbi fil-metabolizmu u n-nutrizzjoni ipoglicemija mhux komuni żieda fl-aptit mhux komuni
English: Glimepiride inhibits the glucose production in the liver by increasing the intracellular concentration of fructose-2,6-bisphosphate, which in turn inhibits the gluconeogenesis.
Maltese: Glimepiride jinibixxi l-produzzjoni ta' glukosju fil-fwied billi jżid il-konċentrazzjoni intraċellolari ta' fructose-2,6-bisphosphate, li wara huwa wholl jinibixxi l-glukoneoġenesi.
English: Musculoskeletal and connective tissue disorders bone fracture7
Maltese: Disturbi muskolu-skeletriċi u tattessuti konnettivi ksur ta' għadam7
English: Treatment of patients with G6PD-deficiency with sulfonylurea agents can lead to haemolytic anaemia.
Maltese: Kura ta' pazjenti b'nuqqas ta' G6PD b'sustanzi minn sulfonylurea tista' twassal għal anemija emolitika.
English: These problems generally get better after you stop taking Tandemact.
Maltese: Generalment, dawn il-problemi jsiru aħjar meta tieqaf tieħu Tandemact.
English: Each tablet contains 30 mg of pioglitazone (as hydrochloride) and 4 mg of glimepiride.
Maltese: Kull pillola fiha 30 mg pioglitazone (bħala hydrochloride) u 4 mg glimepiride.
English: Co-administration of pioglitazone with sulphonylureas does not appear to affect the pharmacokinetics of the sulphonylurea.
Maltese: L-għotja ta' pioglitazone flimkien ma' sulphonylureas ma tidhirx li taffettwa il-farmakokinetika ta' sulphonylurea.
English: The following statements reflect the pharmacokinetic properties of the individual active substances of Tandemact.
Maltese: Id-dikjarazzjonijiet li ġejjin jirriflettu il-proprjetajiet farmakokinetiċi tas-sustanzi attivi individwali f'Tandemact.
English: coughs and colds or used in life-threatening emergencies) - nicotinic acid (to treat high cholesterol level) - long-term use of laxatives (to treat constipation) - phenytoin (to treat fits) - barbiturates (to treat nervousness and sleep problems) - azetazolamide (to treat increased pressure in the eye also called glaucoma) - diazoxide (to treat high blood pressure or low blood sugar) - rifampicin (to treat infections, tuberculosis) - glucagon (to treat severe low blood sugar levels)
Maltese: - chlorpromazine u derivitivi tal-phenothiazine (biex jittrattaw disturbi mentali serji) - adrenalina u simpatomimetiċi (biex izidu t-tahbit tal-qalb, biex jittrattaw l-asthma jew konġestjoni nasali, sogħla u riħ jew emerġenzi tal-periklu għall-ħajja) - nicotinic acid (biex jittrattaw livell għoli tal-kolesterol)
English: common fatigue uncommon
Maltese: Komuni ipoesteżija komuni
English: Broken bones have been reported commonly (may affect up to 1 in 10 people) in female patients taking Tandemact and have also been reported in male patients (frequency cannot be estimated from the available data) taking Tandemact.
Maltese: Reazzjonijiet allerġiċi kienu rrappurtati bi frekwenza mhux magħrufa (ma tistax tittieħed stima tal frekwenza mid-data disponibbli) f'pazjenti li ħadu Tandemact.