FrancophonIA/ELRC3.0 huggingface dataset:
English: Malformations have been observed in foetuses from efavirenz-treated monkeys (see section 5.3).
Slovenian: Malformacije ploda so opažali tudi pri opicah, ki so jim dajali efavirenz (glejte poglavje 5.3).
English: Metabolism and nutrition disorders common hypertriglyceridaemia*
Slovenian: Presnovne in prehranske motnje pogosti hipertrigliceridemija*
English: Taking these medicines with SUSTIVA could create the potential for serious and/or life-threatening sideeffects or stop SUSTIVA from working properly.
Slovenian: Jemanje teh zdravil skupaj z zdravilom SUSTIVA bi lahko povzročilo resne in/ali življenjsko nevarne neželene učinke ali preprečilo pravilno delovanje zdravila SUSTIVA .
English: The pharmacokinetic parameters for efavirenz at steady state in paediatric patients were predicted by a population pharmacokinetic model and are summarized in Table 4 by weight ranges that correspond to the recommended doses.
Slovenian: Farmakokinetični parametri efavirenza v stanju dinamičnega ravnovesja pri pediatričnih bolnikih so bili predvideni s populacijskim modelom farmakokinetike in so povzeti v preglednici 4, razvrščeni po telesni masi, ki ustreza priporočenim odmerkom.
English: Sertraline (a medicine used to treat depression): your doctor may need to change your dose of sertraline.
Slovenian: Sertralin (zdravilo za zdravljenje depresije): zdravnik vam bo morda spremenil odmerek sertralina.
English: Efavirenz is an in vivo inducer of CYP3A4, CYP2B6 and UGT1A1.
Slovenian: Efavirenz je induktor CYP3A4, CYP2B6 in UGT1A1 in vivo.
English: SUSTIVA is not recommeded for children under the age of 3 months or weighing less than 3.5 kg because it has not been adequately studied in these patients.
Slovenian: Uporaba zdravila SUSTIVA ni priporočljiva pri otrocih, mlajših od 3 mesecev ali lažjih od 3,5 kg, saj pri teh bolnikih ni bila ustrezno raziskana.
English: Rash was reported more frequently in children (59 of 182 (32%) treated with efavirenz) and was more often of higher grade than in adults (severe rash was reported in 6 of 182 (3.3%) of children).
Slovenian: Pri otrocih so pogosteje poročali o izpuščaju (59 od 182 (32 %) otrok, zdravljenih z efavirenzem), ki je bil tudi pogosteje hujši kot pri odraslih (o hudi obliki izpuščaja so poročali pri 6 od 182 (3,3 %) otrok).
English: Your doctor may consider changing your dose or giving you an alternative antibiotic.
Slovenian: Zdravnik vam bo po potrebi lahko spremenil odmerek ali vam predpisal drug antibiotik.
English: Concomitant administration of velpatasvir/sofosbuvir/ voxilaprevir with efavirenz is not recommended, as it may decrease concentrations of velpatasvir and voxilaprevir.
Slovenian: Sočasna uporaba efavirenza in velpatasvira/sofosbuvira/ voksilaprevira ni priporočljiva, saj lahko zmanjša koncentracijo velpatasvira in voksilaprevira.
English: CD4+ percentage was 13%.
Slovenian: in mediana odstotka CD4+ je bila 30 %.
English: Patients with a prior history of psychiatric disorders appear to be at greater risk of these serious psychiatric adverse reactions.
Slovenian: Bolniki, ki so že v preteklosti imeli psihiatrične motnje, so bolj nagnjeni k resnim psihiatričnim neželenim učinkom.
English: The nervous system symptoms tend to occur when treatment is first started, but generally decrease in the first few weeks.
Slovenian: Simptomi, povezani z živčnim sistemom, se najraje pojavijo, ko z zdravljenjem pričnemo prvič, vendar se običajno v prvih nekaj tednih zmanjšajo.
English: SUSTIVA may make hormonal contraceptives less likely to work.
Slovenian: Zdravilo SUSTIVA lahko zmanjša delovanje hormonskih kontraceptivov.
English: These drugs include: - antiarrhythmics of classes IA and III, - neuroleptics, antidepressive agents, - certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones,
Slovenian: Med taka zdravila sodijo: - antiaritmiki razreda IA in III, - nevroleptiki, antidepresivi, - določeni antibiotiki, vključno z učinkovinami iz naslednjih razredov: makrolidi, fluorokinoloni,
English: If efavirenz is coadministered with rifampicin to patients weighing 50 kg or more, an increase in the dose of efavirenz to 800 mg/day may be considered (see section 4.5).
Slovenian: Če se efavirenz uporablja sočasno z rifampicinom pri bolnikih s telesno maso 50 kg ali več, lahko po potrebi povečate odmerek efavirenza na 800 mg/dan (glejte poglavje 4.5).
English: Concomitant use of posaconazole and efavirenz should be avoided unless the benefit to the patient outweighs the risk.
Slovenian: Sočasni uporabi posakonazola in efavirenza se je treba izogibati, razen če korist za bolnika pretehta tveganje.
English: SUSTIVA may reduce the amount of voriconazole in your blood and voriconazole may increase the amount of SUSTIVA in your blood.
Slovenian: Zdravilo SUSTIVA lahko zmanjša količino vorikonazola v krvi, vorikonazol pa lahko poveča količino zdravila SUSTIVA v krvi.
English: Dose adjustments of calcium channel blockers should be guided by clinical response (refer to the Summary of Product Characteristics for the calcium channel blocker).
Slovenian: Odmerke zaviralcev kalcijevih kanalčkov je treba prilagoditi glede na klinični odziv (glejte Povzetek glavnih značilnosti zdravila za zaviralec kalcijevih kanalčkov).
English: If you had a rash while taking another NNRTI, you may be at a higher risk of getting a rash with SUSTIVA.
Slovenian: Če ste imeli izpuščaj med jemanjem drugega NNRTI-ja, je pri vas večja možnost pojava izpuščaja zaradi zdravila SUSTIVA.
English: If a patient is already taking St. John's wort, stop St. John's wort, check viral levels and if possible efavirenz levels.
Slovenian: Če bolnik že jemlje šentjanževko, naj preneha, preveri naj se koncentracija virusa in, če je možno, koncentracija efavirenza.
English: 7.5 to < 15
Slovenian: 7,5 do < 15
English: In HIV infected patients at steady state, mean Cmax, mean Cmin, and mean AUC were linear with 200 mg, 400 mg, and 600 mg daily doses.
Slovenian: Pri bolnikih, okuženih s HIV, so bile povprečna Cmax, povprečna Cmin in povprečna AUC v stanju dinamičnega ravnovesja linearno odvisne od dnevnega 200 mg, 400 mg in 600 mg odmerka.
English: b EFV, efavirenz; ZDV, zidovudine; 3TC, lamivudine; IDV, indinavir; NRTI, nucleoside reverse transcriptase inhibitor; NFV, nelfinavir.
Slovenian: EFV, efavirenz; ZDV, zidovudin; 3TC, lamivudin; IDV, indinavir; NRTI, zaviralec nukleozidne reverzne transkriptaze; NFV, nelfinavir.
English: *compared to 200 mg twice daily alone ** compared to 600 mg once daily alone (competitive inhibition of oxidative metabolism)
Slovenian: Cmax: ↔ ** *v primerjavi z 200 mg samim dvakrat na dan **v primerjavi s 600 mg samim enkrat na dan (kompetitivno zaviranje oksidativne presnove)
English: Taking these medicines with SUSTIVA could create the potential for serious and/or life-threatening side-effects or stop SUSTIVA from working properly.
Slovenian: Jemanje teh zdravil skupaj z zdravilom SUSTIVA bi lahko povzročilo resne in/ali življenjsko nevarne neželene učinke ali preprečilo pravilno delovanje zdravila SUSTIVA.
English: The mean Cmax of efavirenz in subjects with CYP2B6 *6/*6 genotype following the administration of 600 mg daily dose for 14 days was 2.25-fold the mean Cmax observed in subjects with CYP2B6 *1/*1 genotype.
Slovenian: Povprečna Cmax efavirenza pri osebah z genotipom CYP2B6 *6/*6 je bila po 14-dnevni uporabi 600 mg na dan 2,25-krat tolikšna kot povprečna Cmax pri osebah z genotipom CYP2B6 *1/*1.
English: EFV +
Slovenian: EFV + IDV
English: The potential for cross resistance between efavirenz and PIs is low because of the different enzyme targets involved.
Slovenian: Možnost navzkrižne rezistence med efavirenzem in zaviralci proteaze je majhna, ker pri tem sodelujejo različni tarčni encimi.
English: Bottle: 30 film-coated tablets
Slovenian: Plastenka: 30 filmsko obloženih tablet
English: In order to improve the tolerability of nervous system adverse reactions, bedtime dosing is recommended (see section 4.8).
Slovenian: Da bi bolniki bolje prenašali neželene učinke na živčni sistem, priporočamo odmerjanje zvečer pred spanjem (glejte poglavje 4.8).
English: SUSTIVA may interact with other medicines, including herbal preparations such as Ginkgo biloba extracts.
Slovenian: Med zdravilom SUSTIVA in drugimi zdravili, vključno s pripravki rastlinskega izvora, kot so izvlečki ginka (Ginkgo biloba), lahko pride do medsebojnega vpliva.
English: Information regarding post-marketing surveillance
Slovenian: Informacije pridobljene v času trženja zdravila
English: When taken with rifampicin in patients weighing 50 kg or greater, increasing efavirenz daily dose to 800 mg may provide exposure similar to a daily dose of 600 mg when taken without rifampicin.
Slovenian: Pri bolnikih s telesno maso 50 kg ali več je pri jemanju z rifampicinom pri povečanju dnevnega odmerka efavirenza na 800 mg izpostavitev podobna kot pri dnevnem odmerku 600 mg, če bolnik ne jemlje rifampicina.
English: Decreased exposure of the immunosuppressant may be expected (CYP3A4 induction).
Slovenian: Lahko pričakujemo zmanjšano izpostavitev imunosupresivom (indukcija CYP3A4).
English: Each carton contains 1 bottle of 30 filmcoated tablets.
Slovenian: Ena škatla vsebuje 1 plastenko s 30 filmsko obloženimi tabletami.
English: These are listed under Do not take SUSTIVA, at the start of Section 2.
Slovenian: Ta zdravila so našteta na začetku 2. poglavja pod naslovom Ne jemljite zdravila SUSTIVA.
English: Pharmacotherapeutic group: Antivirals for systemic use, non-nucleoside reverse transcriptase inhibitors.
Slovenian: Farmakoterapevtska skupina: Zdravila za sistemsko zdravljenje virusnih infekcij, nenukleozidni zaviralci reverzne transkriptaze.
English: Cmax: ↔ 11% (CYP3A induction - effect on boceprevir) *0-8 hours
Slovenian: AUC: ↔ 20 % Cmax: ↔ 11 % (indukcija CYP3A - vpliv na boceprevir) *0-8 ur
English: If you are affected your doctor may suggest that you take SUSTIVA at bedtime and on an empty stomach.
Slovenian: Če se pojavijo pri vas, vam bo zdravnik morda svetoval, da zdravilo SUSTIVA jemljete pred spanjem in na tešče.
English: The effect of efavirenz on the QTc interval was evaluated in an open-label, positive and placebo controlled, fixed single sequence 3-period, 3-treatment crossover QT study in 58 healthy subjects enriched for CYP2B6 polymorphisms.
Slovenian: Vpliv efavirenza na interval QTc so ovrednotili v odprti, pozitivni, s placebom nadzorovani študiji QT pri 58 zdravih preiskovancih, obogatenih za polimorfizme CYP2B6; študija je bila navzkrižna, s fiksnim enojnim zaporedjem ter 3 obdobji in 3 zdravljenji.
English: When efavirenz is coadministered with an anticonvulsant that is a substrate of CYP450 isoenzymes, periodic monitoring of anticonvulsant levels should be conducted.
Slovenian: Ob sočasni uporabi efavirenza in antikonvulziva, ki je substrat izoencimov CYP450, je treba periodično nadzorovati koncentracije antikonvulzivov.
English: if you have a history of convulsions (fits or seizures) or if you are being treated with anticonvulsant therapy such as carbamazepine, phenobarbital and phenytoin.
Slovenian: če ste v preteklosti imeli konvulzije (napade krčev) ali prejemate zdravila proti krčem, kot so karbamazepin, fenobarbital in fenitoin.
English: PHARMACEUTICAL FORM AND CONTENTS 30 hard capsules
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 30 trdih kapsul
English: SUSTIVA contains lactose in each 600-mg daily dose.
Slovenian: Zdravilo SUSTIVA vsebuje laktozo v vsakem 600-mg dnevnem odmerku.
English: Packs of 30 x 1 or multipacks of 90 (3 packs of 30 x 1) film-coated tablets in aluminium/PVC perforated unit dose blisters.
Slovenian: Zavoj po 30 x 1 ali multi pakiranje po 90 (3 zavoji po 30 x 1) filmsko obloženih tablet v aluminijevih/PVC perforiranih pretisnih omotih za enkratni odmerek.
English: NC = F, noncompleter = failure.
Slovenian: NK = NA, ni končal = napaka analize b
English: Other medicines used for HIV infection: protease inhibitors: darunavir, indinavir, lopinavir/ritonavir, ritonavir, ritonavir boosted atazanavir, saquinavir or fosamprenavir/saquinavir.
Slovenian: Druga zdravila, ki se uporabljajo pri okužbi s HIV: zaviralce proteaze: darunavir, indinavir, lopinavir/ritonavir, ritonavir, z ritonavirjem okrepljen atazanavir, sakvinavir ali fosamprenavir/sakvinavir.
English: After administration of the efavirenz-food mixture, an additional small amount (approximately 2 teaspoons) of food must be added to the empty mixing container, stirred to disperse any remaining residue of the medicinal product, and administered to the patient.
Slovenian: Po zaužitju mešanice hrane in efavirenza je treba dati v prazno posodo, v kateri ste pripravljali mešanico, še manjšo količino hrane (približno 2 čajni žlički) ter pomešati, da se zajame še morebitne ostanke zdravila na posodi, ter dati bolniku, naj hrano zaužije.
English: PHARMACEUTICAL FORM AND CONTENTS 90 hard capsules: bottle
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 90 trdih kapsul: plastenka
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral agents have a higher risk for severe and potentially life-threatening liver problems.
Slovenian: Pri bolnikih s kroničnim hepatitisom B ali C, ki se zdravijo s kombinacijo protiretrovirusnih učinkovin, obstaja večje tveganje za hude in življenjsko nevarne težave z jetri.
English: This mutation was observed in 90% of patients receiving efavirenz with virological failure.
Slovenian: To mutacijo so opazili pri 90 % bolnikov, ki so prejemali efavirenz, vendar se niso odzvali na zdravljenje.
English: Concomitant administration of atovaquone/proguanil with efavirenz should be avoided.
Slovenian: Sočasni uporabi atovakona/progvanila in efavirenza se je treba izogibati.
English: Among co-infected patients, 3% of those treated with efavirenz and 2% in the control arm discontinued because of liver disorders (see section 4.4).
Slovenian: Med sočasno okuženimi bolniki je 3 % tistih, ki so jemali efavirenz, in 2 % bolnikov iz kontrolnega kraka prekinilo zdravljenje zaradi bolezni jeter (glejte poglavje 4.4).
English: Forty-three patients 3 months to 21 years of age (median 9.6 years) were dosed with SUSTIVA.
Slovenian: Z zdravilom SUSTIVA se je zdravilo triinštirideset bolnikov, starih od 3 mesecev do 21 let (mediana 9,6 leta).
English: Severe skin reactions such as Stevens-Johnson syndrome and erythema multiforme; psychiatric adverse reactions including severe depression, death by suicide, and psychosis like behaviour; and seizures have been reported in patients treated with efavirenz.
Slovenian: Pri bolnikih, zdravljenih z efavirenzem, so poročali o hudih kožnih reakcijah, kot sta Stevens-Johnsonov sindrom in multiformni eritem, o psihiatričnih neželenih učinkih, vključno s hudo depresijo, smrtjo zaradi samomora in vedenjem, podobnem psihozi, ter o krčih.
English: 5 to < 7.5
Slovenian: 5 do < 7,5
English: The capsules must be opened carefully so that the contents do not spill or escape into the air.
Slovenian: Kapsule morate odpreti previdno ter se tako izogniti raztresenju ali razpršitvi vsebine kapsule po zraku.
English: Liver enzymes in hepatitis B or C co-infected patients: in the long-term data set from study 006, 137 patients treated with efavirenz-containing regimens (median duration of therapy, 68 weeks) and 84 treated with a control regimen (median duration, 56 weeks) were seropositive at screening for hepatitis B (surface antigen positive) and/or C (hepatitis C antibody positive).
Slovenian: Jetrni encimi pri bolnikih, sočasno okuženih s hepatitisom B ali C: po dolgoročnih podatkih iz študije 006 je bilo ob presejanju seropozitivnih na hepatitis B (pozitivnih na površinski antigen) in/ali C (pozitivnih na protitelo proti hepatitisu C) 137 bolnikov na režimu, ki je vseboval efavirenz (mediana vrednost časa trajanja zdravljenja 68 tednov), in 84 bolnikov na kontrolnem režimu (mediana vrednost časa trajanja 56 tednov).
English: Each carton contains 1 bottle of 90 hard capsules.
Slovenian: Ena škatla vsebuje 1 plastenko z 90 trdimi kapsulami.
English: For patients at least 3 months old and weighing at least 3.5 kg who cannot swallow capsules, the capsule contents can be administered with a small amount (1-2 teaspoons) of food using the capsule sprinkle method of administration.
Slovenian: Za bolnike, stare najmanj 3 mesece, ki tehtajo najmanj 3,5 kg in ne morejo pogoltniti kapsul, se lahko vsebina kapsule zmeša z majhno količino hrane (1-2 čajni žlički).
English: Atazanavir (pm): AUC: ↔*/** (↓10 to ↑26)
Slovenian: atazanavir (popoldne): AUC: ↔*/** (↓ 10 do
English: One hundred two patients 3 months to 16 years of age (median 5.7 years) were treated with SUSTIVA.
Slovenian: Z zdravilom SUSTIVA sta se zdravila sto dva bolnika, stara od 3 mesecev do 16 let (mediana 5,7 leta).
English: Interactions between efavirenz and protease inhibitors, antiretroviral agents other than protease inhibitors and other non-antiretroviral medicinal products are listed in Table 1 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, and once every 8 or 12 hours as “q8h” or “q12h”).
Slovenian: Interakcije med efavirenzem in zaviralci proteaze, protiretrovirusnimi učinkovinami, ki niso zaviralci proteaze, in drugimi neprotiretrovirusnimi zdravili so navedene v preglednici 1 spodaj (povečanje je označeno z znakom "↑", zmanjšanje z "↓", brez spremembe z "↔", ter enkrat na 8 ur oz. 12 ur z oznako "q8h" oz. "q12h").
English: Interactions between efavirenz and protease inhibitors, antiretroviral agents other than protease inhibitors and other non-antiretroviral medicinal products are listed in Table 2 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, and once every 8 or 12 hours as “q8h” or “q12h”).
Slovenian: Interakcije med efavirenzem in zaviralci proteaze, protiretrovirusnimi učinkovinami, ki niso zaviralci proteaze, in drugimi neprotiretrovirusnimi zdravili so navedene v preglednici 3 spodaj (povečanje je označeno z znakom "↑", zmanjšanje z "↓", brez spremembe z "↔", ter enkrat na 8 ur oz. 12 ur z oznako "q8h" oz. "q12h").
English: AUC: ↑ 21% Cmin: ↑ 17% Cmax: ↑ 15% (CYP3A4 inhibition)
Slovenian: AUC : ↑ 21 % Cmin: ↑ 17 % Cmax: ↑ 15 % (inhibicija CYP3A4)
English: No additional food should be consumed for up to 2 hours after administration of efavirenz.
Slovenian: Do 2 uri po zaužitju efavirenza se ne sme uživati dodatne hrane.
English: AUC: ↓ 51% Cmax: ↓ 21% Dihydroartemisinin: AUC: ↓ 46% Cmax: ↓ 38% Lumefantrine:
Slovenian: AUC: ↓ 51 % Cmax: ↓ 21 % dihidroartemizinin: AUC: ↓ 46 % Cmax: ↓ 38 % lumefantrin:
English: The AUC and Cmax of a single 600 mg dose of efavirenz film-coated tablets in uninfected volunteers was increased by 28% (90% CI: 22-33%) and 79% (90% CI: 58-102%), respectively, when given with a high fat meal, relative to when given under fasted conditions (see section 4.4).
Slovenian: Pri neokuženih prostovoljcih sta bili AUC in Cmax po enkratnem odmerku 600 mg filmsko obložene tablete efavirenza ob obroku z veliko maščobami povečani za 28 % (90-odstotni IZ: 22-33 %) oziroma 79 % (90-odstotni IZ: 58 - 102 %) v primerjavi z vrednostma na tešče (glejte poglavje 4.4).
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 50 mg hard capsules SUSTIVA 100 mg hard capsules SUSTIVA 200 mg hard capsules
Slovenian: IME ZDRAVILA SUSTIVA 50 mg trde kapsule SUSTIVA 100 mg trde kapsule SUSTIVA 200 mg trde kapsule
English: Outer carton PC:
Slovenian: Škatla PC:
English: This loss is due to significant decreases in elbasvir and grazoprevir plasma concentrations caused by CYP3A4 induction.
Slovenian: Do te izgube pride zaradi pomembnega zmanjšanja koncentracije elbasvira in grazoprevira v plazmi, ki ga povzroči indukcija CYP3A4.
English: Efavirenz levels may increase on stopping St. John's wort and the dose of efavirenz may need adjusting.
Slovenian: Koncentracija efavirenza se lahko po prenehanju jemanja šentjanževke poveča, zato je morda potrebno prilagoditi odmerek efavirenza.
English: Methadone (a medicine used to treat opiate addiction): your doctor may recommend an alternative treatment.
Slovenian: Metadon (zdravilo za zdravljenje odvisnosti od opiatov): zdravnik vam bo morda svetoval drugo zdravljenje.
English: AUC: ↓ 13% Cmin: ↓ 31% Cmax: ↓ 15% (CYP3A4 induction) Efavirenz:
Slovenian: AUC : ↓ 13 % Cmin : ↓ 31 % Cmax: ↓ 15 % (indukcija CYP3A4) efavirenz:
English: In a taste preference study in adults, SUSTIVA mixed with grape jelly received the best rating.
Slovenian: V študiji okusnosti, opravljeni z odraslimi, je najvišje ocene prejela mešanica zdravila SUSTIVA z grozdnim želejem.
English: < 50 copies/ml (95% C.I.
Slovenian: < 50 kopij/ml (95-odstotni IZ b)
English: Medicines used to treat fungal infections (antifungals): voriconazole.
Slovenian: Zdravila za zdravljenje glivnih okužb (antimikotiki): vorikonazol.
English: SUSTIVA may reduce the amount of itraconazole in your blood.
Slovenian: Zdravilo SUSTIVA lahko zmanjša količino itrakonazola v krvi.
English: These side effects may start in the first 1 or 2 days of treatment and usually go away after the first 2 to 4 weeks.
Slovenian: Ti neželeni učinki se lahko pojavijo 1. ali 2. dan zdravljenja in običajno prenehajo po prvih 2 do 4 tednih.
English: Concomitant administration of simeprevir with efavirenz resulted in significantly decreased plasma concentrations of simeprevir due to CYP3A induction by efavirenz, which may result in loss of therapeutic effect of simeprevir.
Slovenian: Sočasna uporaba simeprevirja z efavirenzem je pomembno zmanjšala plazemske koncentracije simeprevirja zaradi indukcije CYP3A z efavirenzem, kar lahko vodi do izgube terapevtskega učinka simeprevirja.
English: No clinically significant effect on efavirenz pharmacokinetics.
Slovenian: Ni klinično pomembnega učinka na farmakokinetiko efavirenza.
English: The median time on study therapy was 132 weeks; 27% of patients discontinued before Week 48.
Slovenian: Mediana časa zdravljenja v študiji je bila 132 tednov; 27 % bolnikov je zdravljenje prekinilo pred 48. tednom.
English: imidazole and triazole antifungal agents, - certain non-sedating antihistamines (terfenadine, astemizole), - cisapride, - flecainide, - certain antimalarials, - methadone.
Slovenian: imidazoli in triazolski antimikotiki, - določeni nesedativni antihistaminiki (terfenadin, astemizol), - cisaprid, - flekainid, - določeni antimalariki, - metadon.
English: Compounds or herbal preparations (for example Ginkgo biloba extracts and St. John's wort) which induce these enzymes may give rise to decreased plasma concentrations of efavirenz.
Slovenian: Snovi ali pripravki rastlinskega izvora (npr. izvlečki ginka in šentjanževke), ki inducirajo ta encima, lahko pripomorejo k zmanjšanju plazemske koncentracije efavirenza.
English: AUC : ↓ 31% (↓ 8 to ↓ 47) Cmin : ↓ 40%
Slovenian: AUC: ↓ 31 % (↓ 8 do ↓ 47) Cmin: ↓ 40 %
English: < 400 copies/ml (95% C.I.
Slovenian: < 400 kopij/ml (95-odstotni IZb)
English: What SUSTIVA contains
Slovenian: Kaj vsebuje zdravilo SUSTIVA
English: Efavirenz must not be administered concurrently with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil, or ergot alkaloids (for example, ergotamine, dihydroergotamine,
Slovenian: Efavirenza se ne sme jemati hkrati s terfenadinom, astemizolom, cisapridom, midazolamom, triazolamom, pimozidom, bepridilom ali ergot alkaloidi (npr. ergotaminom, dihidroergotaminom,
English: Efavirenz is contraindicated with concomitant use of drugs (they may cause prolonged QTc interval and Torsade de Pointes) such as: antiarrhythmics of classes IA and III, neuroleptics and antidepressant agents, certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones, imidazole, and triazole antifungal agents, certain non-sedating antihistaminics (terfenadine, astemizole), cisapride, flecainide, certain antimalarials and methadone (see section 4.3).
Slovenian: Efavirenz je kontraindiciran pri sočasni uporabi zdravil (povzročijo lahko podaljšanje intervala QTc in torsade de pointes) kot so: antiaritmiki razreda IA in III, nevroleptiki in antidepresivi, določeni antibiotiki, vključno z nekaterimi učinkovinami iz naslednjih razredov: makrolidi, fluorokinoloni, imidazoli in triazolski antimikotiki, določeni nesedativni antihistaminiki (terfenadin, astemizol), cisaprid, flekainid, določeni antimalariki in metadon (glejte poglavje 4.3).