FrancophonIA/ELRC3.0 huggingface dataset:
English: ≥2-step worsening n (%)
Croatian: Pogoršanje za ≥2 koraka n (%)
English: Your baby's doctor will advise you and decide how long your baby should be treated with Lucentis.
Croatian: Djetetov liječnik će Vas savjetovati i odlučiti koliko dugo
English: - Prior to use, the unopened vial may be kept at room temperature (25°C) for up to 24 hours.
Croatian: - Prije upotrebe, neotvorena bočica može se držati na sobnoj temperaturi (25°C) do 24 sata.
English: For preparation and intravitreal injection the following medical devices for single use are needed: - a 5 µm filter needle (18G x 1½″, 1.2 mm x 40 mm, provided) - a 1 ml sterile syringe (including a 0.05 ml mark, not included within this pack) and an injection needle (30G x ½″, not included within this pack), for adult patients - a low volume high accuracy sterile syringe, provided together with an injection needle
Croatian: Za pripremu i intravitrealnu injekciju potrebni su sljedeći medicinski proizvodi za jednokratnu uporabu: - igla s filterom promjera pora od 5 µm (18G x 1½″, 1,2 mm x 40 mm, priložena) - sterilna štrcaljka od 1 ml (sadrži 0,05 ml oznaku, nije uključena u ovo pakiranje) i igla za injekciju (30G x ½″, nije uključena u ovo pakiranje), za odrasle bolesnike - precizna sterilna štrcaljka malog volumena koja se isporučuje s iglom za injekciju (30G x ½″) u kompletu VISISURE (nije uključen u ovo pakiranje), za prijevremeno rođenu dojenčad
English: Mean change in visual acuity at Month 6
Croatian: Srednja promjena oštrine vida nakon 6 mjeseci liječenja a
English: Preterm infants
Croatian: ROĐENA DOJENČAD
English: The injection needle should be inserted 3.5-4.0 mm posterior to the limbus into the vitreous cavity, avoiding the horizontal meridian and aiming towards the centre of the globe.
Croatian: Iglu za injekciju treba uvesti 3,5-4,0 mm posteriorno od limbusa u vitrealnu šupljinu,u smjeru središta očne jabučice, pri čemu treba izbjegavati horizontalni meridijan.
English: TE ranibizumab 0.5 mg + laser n=117
Croatian: LIP ranibizumab 0,5 mg + laser n=117
English: The clinical safety and efficacy of Lucentis in patients with PDR have been assessed in Protocol S which evaluated the treatment with ranibizumab 0.5 mg intravitreal injections compared with panretinal photocoagulation (PRP).
Croatian: S koji je ocjenjivao liječenje intravitrealnim injekcijama ranibizumaba 0,5 mg u usporedbi s panretinalnom fotokoagulacijom (PRP).
English: • The treatment of visual impairment due to macular oedema secondary to retinal vein occlusion
Croatian: • Liječenje poremećaja vida uzrokovanog makularnim edemom nastalim kao posljedica okluzije retinalne vene (okluzije njezina ogranka ili okluzije centralne retinalne vene (RVO))
English: For preterm infants the recommended dose for Lucentis is 0.2 mg given as a single intravitreal injection.
Croatian: Preporučena doza Lucentisa za prijevremeno rođenu dojenčad iznosi 0,2 mg u obliku jednokratne intravitrealne injekcije.
English: Prior to use, the unopened vial may be kept at room temperature (25°C) for up to 24 hours.
Croatian: Prije primjene, neotvorena bočica može se držati na sobnoj temperaturi (25°C) do 24 sata.
English: Mean average change in BCVA from Month 1 to Month 12
Croatian: Srednja prosječna promjena BCVA od 1. mjeseca do 12. mjeseca a
English: ≥2-step improvement n (%)
Croatian: Poboljšanje za ≥2 koraka n (%)
English: Gain of ≥15 letters in visual acuity at Month 12 (%) Proportion (%) receiving laser rescue over 12 months
Croatian: Povećanje vidne oštrine za ≥15 slova nakon 12 mjeseci
English: - Keep the pre-filled syringe in its unopened tray in the carton in order to protect from light.
Croatian: - Napunjenu štrcaljku držite u zatvorenoj kaseti u kutiji radi zaštite od svjetlosti.
English: Sham/Lucentis 0.5 mg (n=132)
Croatian: Placebo postupak/ Lucentis 0,5 mg (n=132)
English: Single-use vial for intravitreal use only.
Croatian: Bočica za jednokratnu uporabu isključivo za intravitrealnu primjenu.
English: After 6 months, patients in the sham-control arms switched to 0.5 mg ranibizumab.
Croatian: Nakon 6 mjeseci, bolesnike prvotno uvrštene u skupinu s prividno davanim injekcijama prebacilo se na liječenje ranibizumabom u dozi od 0,5 mg.
English: Sham/Lucentis 0.5 mg (n=130)
Croatian: Placebo postupak/Lucentis 0,5 mg (n=130)
English: After injection, do not recap the needle or detach it from the syringe.
Croatian: Nakon primjene injekcije nemojte ponovno stavljati poklopac na iglu ili je odvajati od štrcaljke.
English: The vial is for single use only.
Croatian: Bočica je samo za jednokratnu uporabu.
English: Loss of <15 letters in visual acuity (%)
Croatian: Smanjenje vidne oštrine za <15 slova a
English: Vial-only pack
Croatian: Pakiranje samo s bočicom
English: - If your baby gets any side effects, talk to your baby's doctor.
Croatian: - Ako primijetite bilo koju nuspojavu kod Vašeg djeteta, potrebno je obavijestiti djetetovog liječnika.
English: When initiating ranibizumab therapy, caution should be used in patients with these risk factors for retinal pigment epithelial tears.
Croatian: U bolesnika u kojih postoje spomenuti čimbenici rizika za nastanak razderotine pigmentnog epitela mrežnice, terapiju ranibizumabom je potrebno započeti oprezno.
English: For preparation and intravitreal injection the following medical devices for single use are needed: - a 5 µm filter needle (18G) - a 1 ml sterile syringe (including a 0.05 ml mark) and an injection needle (30G x ½″), for adult patients - a low volume high accuracy sterile syringe, provided together with an injection needle
Croatian: Za pripremu i intravitrealnu injekciju potrebni su sljedeći medicinski proizvodi za jednokratnu uporabu: - igla s filterom promjera pora od 5 µm (18G) - sterilna štrcaljka od 1 ml (sadrži 0,05 ml oznaku) i igla za injekciju (30G x ½″), za odrasle bolesnike - precizna sterilna štrcaljka malog volumena koja se isporučuje s iglom za injekciju (30G x ½″) u kompletu VISISURE, za prijevremeno rođenu dojenčad Ovi medicinski proizvodi nisu uključeni u ovo pakiranje.
English: - Prior to use, the sealed tray may be kept at room temperature (25°C) for up to 24 hours.
Croatian: Prije primjene, kaseta s lijekom može se držati na sobnoj temperaturi (25°C) do 24 sata.
English: Outcome measure
Croatian: Srednja promjena
English: Gain of ≥15 letters in visual acuity (%)
Croatian: Povećanje vidne oštrine za ≥15 slova nakon 6 mjeseci a
English: There are four situations that require special attention:
Croatian: Četiri situacije zahtijevaju posebnu pozornost:
English: Based on normal approximation.
Croatian: Temeljeno na normalnoj aproksimaciji.
English: Follow your doctor's instruction carefully.
Croatian: Pridržavajte se pažljivo uputa liječnika.
English: Alternatives should be considered, particularly for long-term use.
Croatian: Potrebno je razmotriti alternative, osobito za dugotrajnu primjenu.
English: Observed difference (95% CI)
Croatian: Opažena razlika (95% CI)
English: Most ADRs were Grade 1 or 2.
Croatian: Većina nuspojava bila je stupnja 1 ili 2.
English: The clinical implications of this finding are currently unknown.
Croatian: Kliničke implikacije ovog nalaza trenutno nisu poznate.
English: Talk to your doctor first.
Croatian: Prije toga razgovarajte sa svojim liječnikom.
English: Where possible, alternatives such as azithromycin should be considered.
Croatian: Kad je to moguće, treba razmotriti alternativu kao što je azitromicin.
English: Week 240 N=32
Croatian: Tjedan 240 N=32
English: What EDURANT is and what it is used for
Croatian: Što je EDURANT i za što se koristi
English: The median duration of exposure for patients was 63.5 weeks.
Croatian: Medijan trajanja izloženosti za bolesnike bio je 63,5 tjedana.
English: Doing so could increase the risk of the virus developing resistance.
Croatian: To bi moglo povećati rizik od razvoja otpornosti virusa.
English: No new ADRs were identified compared to those seen in adults.
Croatian: Nisu zabilježene nove nuspojave u usporedbi s onim viđenim u odraslih.
English: Outcome in the week 96 analysis
Croatian: Ishod analize u 96. tjednu
English: It is part of a treatment reducing the amount of virus in the blood.
Croatian: Uzima se u sklopu liječenja koje smanjuje količinu virusa u krvi.
English: Edurant should be used during pregnancy only if the potential benefit justifies the potential risk.
Croatian: Edurant se smije uzimati tijekom trudnoće samo ako potencijalna korist opravdava potencijalni rizik.
English: Typically, such reactions have been observed within the first weeks or months of initiation of CART.
Croatian: Tipično se takve reakcije primijete unutar prvih tjedana ili mjeseci liječenja CART-om.
English: Tell your doctor about your situation
Croatian: Obavijestite liječnika o svom stanju
English: Postpartum (6-12 Weeks) (n=11)
Croatian: Postpartalno (6-12 tjedana) (n=11)
English: Other medicines and EDURANT
Croatian: Drugi lijekovi i EDURANT
English: Resistance was defined as the emergence of any resistance-associated mutation at failure.
Croatian: Rezistencija je bila definirana kao pojava bilo kakve mutacije povezane s rezistencijom kod neuspjeha.
English: Even if you feel better, do not stop taking EDURANT or your other HIV medicines.
Croatian: Čak i ako se osjećate bolje, nemojte prestati uzimati EDURANT ili druge lijekove protiv HIV-a.
English: All other drug-drug interactions shown are predicted.
Croatian: Sve druge prikazane interakcije su predviđene.
English: No mother to child transmission occurred in all 10 infants born to the mothers who completed the trial and for whom the HIV status was available.
Croatian: Nije se pojavio niti jedan prijenos s majke na dijete kod svih 10 novorođenčadi koju su rodile majke koje su završile ispitivanje i čiji je HIV status bio dostupan.
English: Virologic failure and development of resistance
Croatian: Virološki neuspjeh i razvoj rezistencije
English: - Tell your doctor if you have or have had problems with your liver, including hepatitis B and/or C, and/or problems with your kidneys.
Croatian: - Obavijestite liječnika ako imate ili ste imali probleme s jetrom, uključujući hepatitis B i/ili C, i/ili probleme s bubrezima.
English: Your doctor will discuss with you which combination of medicines is best for you.
Croatian: Liječnik će razgovarati s Vama o kombinaciji lijekova koja je najbolja za Vas.
English: When EDURANT was taken with only a protein-rich nutritional drink, exposures were 50% lower than when taken with a meal.
Croatian: Kada se EDURANT uzimao samo s hranjivim proteinskim napitkom, izloženost je bila 50% niža nego kad se uzimao s obrokom.
English: EDURANT has only been used in a limited number of patients of 65 years or older.
Croatian: EDURANT je bio ispitivan samo u ograničenog broja bolesnika u dobi od 65 godina ili starijih.
English: As a precautionary measure, it is preferable to avoid the use of EDURANT during pregnancy.
Croatian: Kao mjera opreza, preporučuje se izbjegavati primjenu EDURANTA tijekom trudnoće.
English: Then take the next dose as usual.
Croatian: Sljedeću dozu uzmite u uobičajeno vrijeme.
English: Your doctor will advise on which HIV medicines can be combined with EDURANT and together you will decide which combination fits your needs best.
Croatian: Liječnik će Vam savjetovati koji se lijekovi protiv HIV-a mogu kombinirati s EDURANTOM i zajedno ćete odlučiti koja kombinacija najviše odgovara Vašim potrebama.
English: EDURANT has no or negligible influence on the ability to drive and use machines.
Croatian: EDURANT ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Do not stop using EDURANT without talking to your doctor first.
Croatian: Nemojte prestati uzimati EDURANT a da prethodno o tome niste razgovarali sa svojim liječnikom.
English: Date of first authorisation: 28 November 2011 Date of latest renewal: 22 July 2016
Croatian: Datum posljednje obnove odobrenja: 22. srpnja 2016.
English: Paediatric population (12 to less than 18 years of age)
Croatian: Pedijatrijska populacija (u dobi od 12 do manje od 18 godina)
English: Each carton contains one bottle of 30 tablets.
Croatian: Jedna kutija sadrži jednu bocu s 30 tableta.
English: What EDURANT is and what it is used for What you need to know before you take EDURANT How to take EDURANT
Croatian: Što je EDURANT i za što se koristi Što morate znati prije nego počnete uzimati EDURANT Kako uzimati EDURANT
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10) and uncommon (≥ 1/1,000 to < 1/100).
Croatian: Učestalost je definirana kao vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10) i manje često (≥ 1/1000 i < 1/100).
English: Important information about some of the ingredients of EDURANT EDURANT contains lactose.
Croatian: Važne informacije o nekim sastojcima lijeka EDURANT EDURANT sadrži laktozu.
English: Interaction table Interaction studies have only been performed in adults.
Croatian: Tablica interakcija Ispitivanja interakcija provedena su samo u odraslih.
English: It is believed that these symptoms are due to an improvement in the body's immune response, enabling the body to fight infections that may have been present with no obvious symptoms.
Croatian: Vjeruje se da ti simptomi nastaju zbog poboljšanog imunološkog odgovora organizma, što tijelu omogućuje da se bori protiv infekcija koje su mogle biti prisutne i bez vidljivih simptoma.
English: Rilpivirine is primarily metabolised and eliminated by the liver.
Croatian: Rilpivirin se primarno metabolizira i eliminira putem jetre.
English: The terminal elimination half-life of rilpivirine is approximately 45 hours.
Croatian: Terminalno poluvrijeme eliminacije rilpivirina iznosi približno 45 sati.
English: HIV infected mothers must not breastfeed, as there is a possibility of infecting the baby with HIV via breast milk.
Croatian: Majke zaražene HIV-om ne smiju dojiti, jer postoji mogućnost da se dijete zarazi HIV-om putem majčinog mlijeka.
English: EDURANT is not for use in children less than 12 years of age, because it has not been sufficiently studied in these patients.
Croatian: EDURANT nije namijenjen za djecu mlađu od 12 godina, zato što nije dovoljno ispitan u tih bolesnika.
English: Recombinant clinical isolates
Croatian: Rekombinantni klinički izolati
English: Rilpivirine was well tolerated during pregnancy and postpartum.
Croatian: Rilpivirin se dobro podnosio tijekom trudnoće i postpartalno.
English: 60-100 mg once daily, individualised dose
Croatian: 60-100 mg jedanput dnevno, individualizirana doza
English: The E138K substitution emerged most frequently during rilpivirine treatment, commonly in combination with the M184I substitution.
Croatian: Do supstitucije E138K došlo je najčešće tijekom liječenja rilpivirinom, obično u kombinaciji s M184I supstitucijom.
English: MACROLIDE ANTIBIOTICS Clarithromycin
Croatian: MAKROLIDNI ANTIBIOTICI Klaritromicin
English: - Tell your doctor immediately if you notice any symptoms of infections (for example, fever, chills, sweats).
Croatian: - Odmah obavijestite svog liječnika ako primijetite bilo kakve simptome infekcije (na primjer vrućicu, zimicu, znojenje).
English: It is recommended that the film-coated tablet be swallowed whole with water and not be chewed or crushed.
Croatian: Filmom obloženu tabletu preporučuje se progutati cijelu s vodom, bez žvakanja ili drobljenja.
English: Cimetidine Nizatidine Ranitidine
Croatian: Cimetidin Nizatidin Ranitidin
English: If you take didanosine (a medicine to treat HIV infection), no dose adjustment is required.
Croatian: Ako uzimate didanozin (lijek za liječenje HIV infekcije), nije potrebna prilagodba doze.
English: In dogs, cholestasis-like effects were noted.
Croatian: U pasa su zabilježeni učinci slični kolestazi.
English: The trials were identical in design, with the exception of the background regimen (BR).
Croatian: Ispitivanja su imala identičan dizajn, uz izuzetak pratećeg liječenja (BR engl. background regimen).
English: A meal is important to get the right levels of active substance in your body.
Croatian: Obrok je važan zato da bi se dobile potrebne koncentracije djelatne tvari u Vašem tijelu.
English: The most common mutations were the same in the week 48 and week 96 analyses.
Croatian: Najčešće mutacije bile su iste kod analiza u 48. i 96. tjednu.
English: Instructions for proper use in adults and adolescents (12 to less than 18 years of age) The recommended dose of EDURANT is one tablet once a day.
Croatian: Upute za pravilnu primjenu u odraslih i adolescenata (u dobi od 12 do manje od 18 godina) Preporučena doza EDURANTA je jedna tableta jedanput dnevno.
English: N=number of subjects per treatment group; ND=not determined.
Croatian: N = broj ispitanika u terapijskoj skupini; NO = nije određeno.
English: Make sure that you check the following points and tell your doctor if any of these apply to you.
Croatian: Svakako provjerite sljedeće napomene i obavijestite liječnika ako se bilo koja odnosi na Vas.
English: This analysis included 36 patients who had completed at least 48 weeks of treatment or discontinued earlier.
Croatian: Ova analiza uključivala je 36 bolesnika koji su završili najmanje 48 tjedana liječenja ili su ranije prekinuli liječenje.
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Croatian: Ako primijetite bilo koji simptom infekcije ili druge simptome poput mišićne slabosti, slabosti koja počinje u šakama i stopalima te se širi gore prema trupu tijela, lupanja srca, tremora ili hiperaktivnosti, molimo Vas odmah obavijestite liječnika kako biste zatražili potrebno liječenje.
English: Treatment of overdose with rilpivirine consists of general supportive measures including monitoring of vital signs and ECG (QT interval) as well as observation of the clinical status of the patient.
Croatian: Liječenje predoziranja rilpivirinom sastoji se od općih potpornih mjera koje uključuju nadzor vitalnih znakova i EKG-a (QT interval), kao i praćenje kliničkog stanja bolesnika.
English: Alternatively, switching to another ART regimen could be considered.
Croatian: Alternativno se može uzeti u obzir prijelaz na drugi antiretrovirusni režim.
English: Some medicines may affect the levels of EDURANT in the blood when they are taken at the same time as EDURANT.
Croatian: Neki lijekovi mogu utjecati na razinu EDURANTA u krvi kad se uzimaju istovremeno s EDURANTOM.
English: What you need to know before you take EDURANT
Croatian: Što morate znati prije nego počnete uzimati EDURANT
English: Your doctor may evaluate how severe your liver or kidney disease is before deciding if you can take EDURANT.
Croatian: Liječnik može procijeniti težinu bolesti jetre ili bubrega prije nego što odluči možete li uzimati EDURANT.
English: Do not take EDURANT if you are allergic to rilpivirine or any of the other ingredients of this medicine (listed in section 6).
Croatian: Nemojte uzimati EDURANT ako ste alergični na rilpivirin ili neki drugi sastojak ovog lijeka (naveden u dijelu 6).
English: Established and theoretical interactions with selected antiretrovirals and non-antiretroviral medicinal products are listed in table 1.
Croatian: Potvrđene i teorijske interakcije s odabranim antiretrovirusnim i neantiretrovirusnim lijekovima navedene su u tablici 1.
English: Pregnant women should discuss the use of EDURANT with their doctor.
Croatian: Trudnice trebaju razgovarati o primjeni lijeka EDURANT sa svojim liječnikom.
English: CCR5 Antagonists Maraviroc
Croatian: Antagonisti receptora CCR5 Maravirok
English: After oral administration, the maximum plasma concentration of rilpivirine is generally achieved within 4-5 hours.
Croatian: Nakon peroralne primjene, maksimalne koncentracije rilpivirina u plazmi najčešće su dostignute u roku od 4 do 5 sati.
English: The virologic response was generally preserved throughout the study: of the 12 subjects that completed the study, 10 subjects were suppressed at the end of the study; in the other 2 subjects an increase in viral load was observed only postpartum, for at least 1 subject due to suspected suboptimal adherence.
Croatian: Virološki odgovor općenito je bio očuvan tijekom ispitivanja: od 12 ispitanica koje su završile ispitivanje, u 10 ispitanica postojala je supresija na kraju ispitivanja; u preostale 2 ispitanice porast virusnog opterećenja bio je uočen samo postpartalno, za najmanje 1 ispitanicu radi suspektne suboptimalne adherencije.
English: The absolute bioavailability of EDURANT is unknown.
Croatian: Nije poznata apsolutna biološka raspoloživost EDURANTA.
English: The distribution of rilpivirine into compartments other than plasma (e.g., cerebrospinal fluid, genital tract secretions) has not been evaluated in humans.
Croatian: Distribucija rilpivirina u druge odjeljke osim plazme (npr. cerebrospinalni likvor, sekrete genitalnog trakta) nije se procjenjivala u ljudi.
English: Alternatively, switching to another ART regimen could be considered (see sections 4.4, 4.6, 5.1 and 5.2).
Croatian: Alternativno se može uzeti u obzir prijelaz na drugi antiretrovirusni režim (vidjeti dijelove 4.4, 4.6, 5.1 i 5.2).
English: There is no specific antidote for overdose with EDURANT.
Croatian: Ne postoji specifični antidot za predoziranje EDURANTOM.
English: No grade 3-4 laboratory abnormalities for AST/ALT or grade 3-4 ADRs of transaminase increased were reported.
Croatian: Nije bilo prijavljenih odstupanja u laboratorijskim nalazima za AST/ALT stupnja 3-4 niti nuspojava povišenja transaminaza stupnja 3-4.
English: N=number of subjects per treatment group.
Croatian: N=broj ispitanika po liječenoj skupini.
English: Rilpivirine is approximately 99.7% bound to plasma proteins in vitro, primarily to albumin.
Croatian: Približno se 99,7% rilpivirina veže za proteine plazme in vitro, prvenstveno za albumin.
English: A nutritional drink (e.g. protein-rich) alone does not replace a meal.
Croatian: Hranjivi napitak (npr. proteinski napitak) ukoliko se uzima sam, ne može zamijeniti obrok.
English: However, clinical monitoring is recommended as methadone maintenance therapy may need to be adjusted in some patients.
Croatian: Međutim, preporučuje se kliničko praćenje, jer u nekih bolesnika može biti potrebno prilagoditi terapiju održavanja metadonom.
English: Other Antiviral Agents Ribavirin
Croatian: Ostali antivirotici Ribavirin
English: Warnings and precautions Talk to your doctor or pharmacist before taking EDURANT.
Croatian: Upozorenja i mjere opreza Obratite se svom liječniku ili ljekarniku prije nego uzmete EDURANT.
English: EDURANT contains rilpivirine that is used for the treatment of Human Immunodeficiency Virus (HIV) infection.
Croatian: EDURANT sadrži rilpivirin koji se koristi za liječenje infekcije virusom humane imunodeficijencije (HIV).
English: Studies in animals have shown no evidence of relevant embryonic or foetal toxicity or an effect on reproductive function.
Croatian: Ispitivanjima na životinjama nije dokazana važna embrionalna ili fetalna toksičnost ni utjecaj na reproduktivnu funkciju.
English: Tell your doctor if you take: - rifabutin (a medicine to treat some bacterial infections).
Croatian: Obavijestite svog liječnika ako uzimate: - rifabutin (lijek za liječenje nekih bakterijskih infekcija).
English: Do not drive or operate machinery if you feel tired, dizzy or drowsy while taking EDURANT.
Croatian: Nemojte upravljati vozilima niti raditi sa strojevima ako osjećate umor, omaglicu ili pospanost dok uzimate EDURANT.
English: Only adolescents deemed likely to have good adherence to antiretroviral therapy should be treated with rilpivirine, as suboptimal adherence can lead to development of resistance and the loss of future treatment options.
Croatian: Samo adolescenati za koje je procijenjeno da se vjerojatno dobro pridržavaju režima antiretrovirusnog liječenja smiju biti liječeni rilpivirinom, budući da suboptimalno pridržavanje može dovesti do razvoja rezistencije i gubitka budućih mogućnosti liječenja.