FrancophonIA/ELRC3.0 huggingface dataset:
English: In an open-label, comparative, multicenter study comparing voriconazole and itraconazole as primary prophylaxis in adult and adolescent allogeneic HSCT recipients without prior proven or probable IFI, permanent discontinuation of voriconazole due to AEs was reported in 39.3% of subjects versus 39.6% of subjects in the itraconazole arm. Treatment-emergent hepatic AEs resulted in permanent discontinuation of study medication for 50 subjects (21.4%) treated with voriconazole and for 18 subjects (7.1%) treated with itraconazole.
Danish: I et åbent, komparativt multicenterstudie, der sammenlignede voriconazol med itraconazol til primær profylakse hos voksne og unge, der har fået en allogen HSCT, uden forudgående påvist eller sandsynlig invasiv svampeinfektion, blev der rapporteret permanent seponering af voriconazol på grund af bivirkninger hos 39,3% af forsøgspersonerne i forhold til 39,6% af forsøgspersonerne i itraconazol-armen.
English: Immunosuppressants [CYP3A4 substrates] Sirolimus (2 mg single dose)
Danish: Immunosupprimerende midler [CYP3A4-substrater] Sirolimus (2 mg enkeltdosis)
English: Breast-feeding must be stopped on initiation of treatment with Voriconazole Hikma.
Danish: Amning skal ophøre ved initiering af behandling med Voriconazole Hikma.
English: In an independent published study, Oxycodone Cmax ↑ 1.7-fold Oxycodone AUC0-∞ ↑ 3.6-fold
Danish: I et uafhængigt, publiceret studie Oxycodon Cmax ↑ 1,7 gange Oxycodon AUC0-∞ ↑ 3,6 gange
English: If patients develop a rash they should be monitored closely and Voriconazole Hikma discontinued if lesions progress.
Danish: Hvis patienterne udvikler udslæt, bør de monitoreres nøje, og Voriconazole Hikma afbrydes, hvis læsionerne progredierer.
English: The predicted total exposures in children following IV maintenance doses of 4 and 8 mg/kg twice daily were comparable to those in adults following 3 and 4 mg/kg IV twice daily, respectively.
Danish: Den forventede totale eksponering hos børn efter intravenøse vedligeholdelsesdoser på 4 mg/kg og 8 mg/kg 2 gange dagligt var sammenlignelig med den for voksne efter intravenøse doser på hhv. 3 mg/kg og 4 mg/kg 2 gange dagligt.
English: Co-administration of voriconazole and high doses of ritonavir (400 mg and above BID) is contraindicated (see section 4.3).
Danish: Samtidig administration af voriconazol og høj-dosis ritonavir (400 mg og derover BID) er kontraindiceret (se pkt.
English: Squamous cell carcinoma of the skin (SCC) has been reported in relation with long-term VORICONAZOLE HIKMA treatment.
Danish: Planocellulært karcinom i huden (SCC) er blevet rapporeret i forbindelse med langtidbehandling med VORICONAZOLE HIKMA.
English: 9 mg/kg every 12 hours
Danish: 9 mg/kg hver 12. time
English: Rifabutin [potent CYP450 inducer] 300 mg QD
Danish: Rifabutin [potent CYP450-induktor] 300 mg QD
English: Do not take Voriconazole Hikma: - If you are allergic to the active ingredient voriconazole or to sulfobutylether beta cyclodextrin sodium
Danish: Det skal De vide, før De begynder at bruge Voriconazole Hikma Tag ikke Voriconazole Hikma: - Hvis De er allergisk over for det aktive stof voriconazol eller over for sulfobutylether-betacyclodextrinnatrium (anført i punkt 6).
English: While being treated with Voriconazole Hikma:
Danish: Mens De er i behandling med Voriconazole Hikma:
English: If any side effects occur, most are likely to be minor and temporary.
Danish: De fleste bivirkninger er milde og forbigående.
English: Voriconazole should be administered primarily to patients with progressive, possibly life-threatening infections.
Danish: Voriconazol bør fortrinsvis gives til immunkompromitterede patienter med fremadskridende, muligt livstruende infektioner.
English: Voriconazole (N=125)
Danish: Voriconazol (n=125)
English: Electrolyte disturbances such as hypokalaemia, hypomagnesaemia and hypocalcaemia should be monitored and corrected, if necessary, prior to initiation and during voriconazole therapy (see section 4.2).
Danish: Elektrolytforstyrrelser såsom hypokaliæmi, hypomagnesæmi og hypokalcæmi bør monitoreres og om nødvendigt korrigeres, før voriconazolbehandling initieres og under behandlingen (se pkt.
English: Nervous system disorders headache convulsion, syncope, tremor, hypertonia3, paraesthesia, somnolence, dizziness brain oedema, encephalopathy4, extrapyramidal disorder5, neuropathy peripheral, ataxia, hypoaesthesia, dysgeusia hepatic encephalopathy, Guillain-Barre syndrome, nystagmus
Danish: Nervesystemet hovedpine kramper, synkope, tremor, hypertoni3, paræstesi, søvnighed, svimmelhed hjerneødem, encefalopati4, ekstrapyramidal lidelse5, perifer neuropati, ataksi, hypæstesi, dysgeusi hepatisk encefalopati, Guillain-Barrés syndrom, nystagmus
English: Co-administration with sirolimus, since voriconazole is likely to increase plasma concentrations of sirolimus significantly (see section 4.5).
Danish: Samtidig administration af sirolimus, da voriconazol sandsynligvis vil øge plasmakoncentrationerne af sirolimus signifikant (se pkt.
English: and Fusarium spp.
Danish: og Fusarium spp.
English: Gastrointestin al disorders diarrhoea, vomiting, abdominal pain, nausea cheilitis, dyspepsia, constipation, gingivitis peritonitis, pancreatitis, swollen tongue, duodenitis, gastroenteritis, glossitis
Danish: Mave-tarmkanalen diarré, opkastning, abdominalsmerter, kvalme keilit, dyspepsi, obstipation, gingivitis peritonitis, pankreatitis, hævet tunge, duodenitis, gastroenteritis, glossitis
English: In vitro studies showed that voriconazole is metabolised by the hepatic cytochrome P450 isoenzymes, CYP2C19, CYP2C9 and CYP3A4.
Danish: In vitro-studier har vist, at voriconazol metaboliseres via leverens CYP450-isoenzymer CYP2C19, CYP2C9 og CYP3A4.
English: Benzodiazepines (e.g., midazolam, triazolam, alprazolam) [CYP3A4 substrates]
Danish: Benzodiazepiner (f.eks. midazolam, triazolam, alprazolam) [CYP3A4-substrater]
English: • Ciclosporin (used in transplant patients)
Danish: • Ciclosporin (bruges til transplanterede patienter)
English: Itraconazole (N=143)
Danish: Itraconazol (n=143)
English: • Phototoxicity
Danish: Fototoksicitet
English: Cardiac disorders arrhythmia supraventricular, tachycardia, bradycardia ventricular fibrillation, ventricular extrasystoles, ventricular tachycardia, electrocardiogram QT prolonged, supraventricular tachycardia torsades de pointes, atrioventricular block complete, bundle branch block, nodal rhythm
Danish: Hjerte supraventrikulær arytmi, takykardi, bradykardi ventrikulær flimren, ventrikulære ekstrasystoler, ventrikulær takykardi, forlænget QTinterval i ekg, supraventrikulær takykardi torsades de pointes, komplet AV-blok, grenblok, nodal arytmi
English: Respiratory, thoracic and mediastinal disorders respiratory distress9
Danish: Luftveje, thorax og mediastinum åndedrætsbesvær9
English: In vitro studies show that the metabolism of voriconazole may be inhibited by NNRTIs and voriconazole may inhibit the metabolism of NNRTIs.
Danish: Studier in vitro viser, at metaboliseringen af voriconazol kan blive hæmmet af NNRTI, og voriconazol kan hæmme metaboliseringen af NNRTI.
English: Voriconazole N=224
Danish: Voriconazol n=224
English: • Terfenadine (used for allergy)
Danish: • Terfenadin (medicin mod allergi)
English: Stevens-Johnson syndrome, phototoxicity, purpura, urticaria, dermatitis allergic, rash papular, rash macular, eczema toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), angioedema, Actinic keratosis*, pseudoporphyria erythema multiforme, psoriasis, drug eruption cutaneous lupus erythemato sus* ephelides*, lentigo*
Danish: Stevens-Johnsons syndrom, fototoksicitet, purpura, urticaria, allergisk dermatitis, papuløst hududslæt, makuløst hududslæt, eksem toksisk epidermal nekrolyse, lægemiddelreakt ion med eosinofili og systemiske symptomer (DRESS), angioødem, aktinisk keratose*, pseudoporfyri, erythema multiforme, psoriasis, medicinudslæt kutan lupus erythematosus*, efelider*, lentigo*
English: The frequency of phototoxicity reactions is higher in the paediatric population.
Danish: Alvorlige dermatologiske bivirkninger (herunder CSS)Hyppigheden af fototoksiske reaktioner er højere hos den pædiatriske population.
English: Indinavir (800 mg TID) [CYP3A4 inhibitor and substrate]
Danish: Indinavir (800 mg TID) [CYP3A4-hæmmer og -substrat]
English: • candidaemia (another type of fungal infection due to Candida sp.) in non-neutropenic patients (patients without abnormally low white blood cell count),
Danish: • infektion i blodet af Candida-arter (candidæmi) hos patienter, der ikke har et lavt antal hvide blodlegemer
English: parapsilosis and C. tropicalis.
Danish: glabrata sammenlignet med C. albicans, C. parapsilosis og C. tropicalis.
English: In clinical trials, visual impairments (including blurred vision, photophobia, chloropsia, chromatopsia, colour blindness, cyanopsia, eye disorder, halo vision, night blindness, oscillopsia, photopsia, scintillating scotoma, visual acuity reduced, visual brightness, visual field defect, vitreous floaters, and xanthopsia) with voriconazole were very common.
Danish: I kliniske studier med voriconazol er nedsat syn (herunder sløret syn, fotofobi, kloropsi, kromatopsi, farveblindhed, cyanopsi, øjensygdom, aura, natteblindhed, oscillopsi, fotopsi, scintillerende scotom, nedsat synsskarphed, synsklarhed, synsfeltdefekt, øjenflydere og xanthopsi) meget almindeligt.
English: • Inflammation of certain internal organs- pancreas and duodenum, swelling and inflammation of the tongue
Danish: • Betændelse i visse indre organer, bugspytkirtlen og tolvfingertarmen, hævelse og betændelsestilstand i tungen
English: In vitro studies show that voriconazole may inhibit the metabolism of HIV protease inhibitors and the metabolism of voriconazole may also be inhibited by HIV protease
Danish: Studier in vitro viser, at voriconazol kan hæmme metaboliseringen af hivproteasehæmmere, og metaboliseringen af voriconazol kan også blive hæmmet af hivproteasehæmmere.
English: Voriconazole Hikma powder for solution for infusion needs to first be reconstituted with either 19 ml of water for injections or 19 ml of sodium chloride 9 mg/ml (0.9%) solution for injection to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml voriconazole.
Danish: Voriconazole Hikma pulver til infusionsvæske, opløsning, skal første rekonstitueres med enten 19 ml vand til injektionsvæsker eller 19 ml natriumchlorid 9 mg/ml (0,9 %) injektionsvæske, opløsning, så der opnås en mængde, hvoraf der kan trækkes et volumen på 20 ml klart koncentrat indeholdende 10 mg/ml voriconazol.
English: Voriconazole may be coadministered with efavirenz if the voriconazole maintenance dose is increased to 400 mg BID and the efavirenz dose is decreased to 300 mg QD.
Danish: Voriconazol kan administreres sammen med efavirenz, hvis vedligeholdelsesdosis af voriconazol øges til 400 mg BID, og efavirenz-dosis reduceres til 300 mg QD.
English: As you will be given this medicine under close medical supervision, it is unlikely that a dose would be missed.
Danish: Hvis en dosis af Voriconazole Hikma er blevet glemt Da De vil få denne medicin under tæt medicinsk overvågning, er det mindre sandsynligt, at en dosis vil blive glemt.
English: Itraconazole (N=109)
Danish: Itraconazol (n=109)
English: • Squamous cell carcinoma of the skin (SCC)
Danish: Planocellulært karcinom i huden (SCC)
English: Use of standard doses of voriconazole with efavirenz doses of 400 mg QD or higher is contraindicated (see section 4.3).
Danish: Standarddoser af voriconazol sammen med efavirenz-doser på 400 mg QD eller derover er kontraindiceret (se pkt.
English: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including those that are obtained without a prescription.
Danish: Fortæl det altid til lægen eller apoteket, hvis De bruger anden medicin eller har brugt det for nylig.
English: • Ritonavir (used for treating HIV) in doses of 400 mg and more twice daily
Danish: • Ritonavir (medicin mod hiv) i doser på 400 mg og derover 2 gange dagligt
English: Monitoring for voriconazole associated adverse reactions is recommended if voriconazole is used sequentially after fluconazole (see section 4.5).
Danish: Monitorering for voriconazol-relaterede bivirkninger anbefales, hvis voriconazol anvendes sekventielt efter fluconazol (se pkt.
English: The placeboadjusted mean maximum increases in QTc from baseline after 800, 1200 and 1600 mg of voriconazole were 5.1, 4.8, and 8.2 msec, respectively and 7.0 msec for ketoconazole 800 mg. No subject in any group had an increase in QTc of ≥60 msec from baseline.
Danish: De placebo-justerede gennemsnitlige maksimale stigninger i QTc i forhold til baseline efter 800 mg, 1200 mg og 1600 mg voriconazol var henholdsvis 5,1; 4,8 og 8,2 msek.
English: Omeprazole (40 mg QD)* [CYP2C19 inhibitor; CYP2C19 and CYP3A4 substrate]
Danish: Omeprazol (40 mg QD)* [CYP2C19-hæmmer; CYP2C19og CYP3A4-substrat]
English: Voriconazole Hikma contains sodium
Danish: Voriconazole Hikma indeholder natrium
English: Voriconazole (N=248)
Danish: Voriconazol (N=248)
English: The medicines in the following list must not be taken during your Voriconazole Hikma treatment:
Danish: Følgende typer medicin må ikke tages under behandlingen med Voriconazole Hikma:
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu.
Danish: Denne indlægsseddel blev senest revideret MM/ÅÅÅÅ De kan finde yderligere oplysninger om dette lægemiddel på Det Europæiske Lægemiddelagenturs hjemmeside: http://www.ema.europa.eu.
English: • Ritonavir (used for treating HIV) in doses of 100 mg twice daily
Danish: • Ritonavir (medicin mod hiv) i doser på 100 mg 2 gange dagligt.
English: Efavirenz may be co-administered with voriconazole if the maintenance dose of voriconazole is increased to 400 mg every 12 hours and the efavirenz dose is reduced by 50%, i.e. to 300 mg once daily.
Danish: Efavirenz kan administreres sammen med voriconazol, hvis vedligeholdelsesdosis af voriconazol øges til 400 mg hver 12. time, og efavirenz-dosis reduceres med 50 %, dvs. til 300 mg én gang dagligt.
English: When voriconazole is discontinued, ciclosporin levels must be carefully monitored and the dose increased as necessary.
Danish: Når voriconazol seponeres, skal ciclosporinkoncentrationerne monitoreres nøje, og dosis om nødvendigt justeres.
English: Developed proven or probable
Danish: Udviklet påvist eller sandsynlig invasiv svampeinfektion til dag
English: If phototoxic reactions occur multidisciplinary advice should be sought, VORICONAZOLE HIKMA discontinuation and use of alternative antifungal agents should be considered and the patient should be referred to a dermatologist.
Danish: Hvis der opstår fototoksiske reaktioner, bør der søges multidisciplinær rådgivning, og patienten bør henvises til dermatolog.
English: • Health Care Professional (HCP) Checklist for Phototoxicity, SCC and Hepatic toxicity: - Reminds HCPs of the risks of phototoxicity, skin SCC and hepatotoxicity reported with voriconazole use.
Danish: • Tjekliste til læger og sundhedspersonale om fototoksicitet, planocellulært karcinom og hepatisk toksicitet: - Påminde læger og sundhedspersonale om de risici for fototoksicitet, planocellulært hudkarcinom og levertoksicitet, der rapporteres i forbindelse med anvendelse af voriconazol.
English: Long -Acting Opiates [CYP3A4 substrates] Oxycodone (10 mg single dose)
Danish: Langtidsvirkende opiater [CYP3A4-substrater] Oxycodon (10 mg enkeltdosis)
English: Voriconazole is a triazole antifungal agent.
Danish: Voriconazol er et antimykotikum af triazolgruppen.
English: Efavirenz Cmax ↑ 38% Efavirenz AUCτ ↑ 44% Voriconazole Cmax ↓ 61% Voriconazole AUCτ ↓ 77%
Danish: Efavirenz Cmax ↑ 38 % Efavirenz AUCτ ↑ 44 % Voriconazol Cmax ↓ 61 % Voriconazol AUCτ ↓ 77 %
English: In an independent published study, Sirolimus Cmax ↑ 6.6-fold Sirolimus AUC0-∞ ↑ 11-fold
Danish: I et uafhængigt, publiceret studie Sirolimus Cmax ↑ 6,6 gange Sirolimus AUC0-∞ ↑ 11 gange
English: Sulphobutylether beta cyclodextrin sodium (SBECD)
Danish: Sulfobutylether-beta-cyclodextrinnatrium (SBECD).
English: • Tacrolimus (used in transplant patients)
Danish: • Tacrolimus (bruges til transplanterede patienter)
English: Co-administration with high dose ritonavir (400 mg and above twice daily) because ritonavir significantly decreases plasma voriconazole concentrations in healthy subjects at this dose.
Danish: Samtidig administration af højdosis ritonavir (400 mg og derover 2 gange dagligt), da ritonavir ved denne dosis reducerer plasmakoncentrationen af voriconazol signifikant hos raske forsøgspersoner (se pkt.
English: • Flu-like symptoms, irritation and inflammation of the gastrointestinal tract, inflammation of the gastrointestinal tract causing antibiotic associated diarrhoea, inflammation of the lymphatic vessels
Danish: • Influenzalignende symptomer, irritation og betændelse i mave-tarm-kanalen, betændelse i mave-tarm-kanalen, der forårsager diarré i forbindelse med antibiotika, betændelse i lymfekar
English: The powder is reconstituted with either 19 ml of water for injections or 19 ml of sodium chloride 9 mg/ml (0.9%) solution for injection to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml of voriconazole.
Danish: Pulveret skal rekonstitueres med enten 19 ml vand til injektionsvæsker eller 19 ml 9 mg/ml (0,9 %) natriumchlorid-infusionsvæske for at opnå et klart koncentrat, hvorfra der kan trækkes et volumen på 20 ml, der indeholder 10 mg/ml voriconazol.
English: Dose reduction in oxycodone and other long-acting opiates metabolized by CYP3A4 (e.g., hydrocodone) should be considered.
Danish: Dosisreduktion af oxycodon og andre langtidsvirkende opiater, der metaboliseres af CYP3A4 (f.eks. hydrocodon), bør overvejes.
English: Ritonavir Cmax ↓ 25% Ritonavir AUCτ ↓13% Voriconazole Cmax ↓ 24% Voriconazole AUCτ ↓ 39%
Danish: Ritonavir Cmax ↓ 25 % Ritonavir AUCτ ↓13 % Voriconazol Cmax ↓ 24 % Voriconazol AUCτ ↓ 39 %
English: * Primary endpoint of study ** Using a margin of 5%, non inferiority is demonstrated ***Difference in proportions, 95% CI obtained after adjustment for randomization
Danish: * Studiets primære effektmål ** Der påvises non-inferioritet med en margin på 5% ***Forskel i andele, 95% konfidensinterval efter justering for randomisering
English: * Primary endpoint of study ** Using a margin of 5%, non inferiority is demonstrated *** Difference in proportions, 95% CI obtained after adjustment for randomization
Danish: * Studiets primære effektmål ** Der påvises non-inferioritet med en margin på 5% *** Forskel i andele, 95% konfidensinterval efter justering for randomisering
English: The most commonly reported adverse reactions were visual impairment, pyrexia, rash, vomiting, nausea, diarrhoea, headache, peripheral oedema liver function test abnormal, respiratory distress and abdominal pain.
Danish: De hyppigst rapporterede bivirkninger var synsnedsættelse, pyreksi, udslæt, opkastning, kvalme, diarré, hovedpine, perifere ødemer, abnorme leverfunktionsværdier, åndedrætsbesvær og abdominalsmerter.
English: Use of voriconazole in prophylaxis for greater than 180 days (6 months) requires careful assessment of the benefit-risk balance (see sections 4.4 and 5.1).
Danish: Profylaktisk anvendelse af voriconazol i mere end 180 dage (6 måneder) kræver nøje vurdering af benefit/risk-forholdet (se pkt.
English: Efavirenz 300 mg QD, coadministered with voriconazole 400 mg BID)*
Danish: Efavirenz 300 mg QD administreret sammen med voriconazol 400 mg BID)*
English: • Sirolimus (used in transplant patients)
Danish: • Sirolimus (bruges til transplanterede patienter)
English: Dose reduction of vinca alkaloids should be considered.
Danish: vinkaalkaloider bør overvejes.
English: Voriconazole is metabolised by, and inhibits the activity of, cytochrome P450 isoenzymes, CYP2C19, CYP2C9, and CYP3A4.
Danish: Voriconazol metaboliseres af og hæmmer aktiviteten af cytochrom P450-isoenzymerne CYP2C19, CYP2C9 og CYP3A4.
English: • Decreased sensitivity to touch
Danish: • Nedsat berøringsfølelse
English: - If you have any further questions, ask your doctor,pharmacist or nurse.
Danish: Er De i tvivl så spørg lægen eller apoteket.
English: When voriconazole is discontinued, tacrolimus levels must be carefully monitored and the dose increased as necessary.
Danish: Når voriconazole seponeres skal tacrolimuskoncentrationerne monitoreres nøje og dosis om nødvendigt justeres.
English: 3 In clinical studies, response to voriconazole in C. krusei infections was similar to C. albicans, C.
Danish: 3 I kliniske studier svarede responset på voriconazol hos patienter med infektion med C. krusei til responset ved C. albicans, C. parapsilosis og C. tropicalis.
English: 8 See section 4.4.
Danish: 4.4 og 4.5.
English: Voriconazole Hikma is an antifungal medicine.
Danish: Voriconazole Hikma er et middel mod svampeinfektioner.
English: Fluconazole (200 mg QD) [CYP2C9, CYP2C19 and CYP3A4 inhibitor]
Danish: Fluconazol (200 mg QD) (CYP2C9-, CYP2C19- og CYP3A4-hæmmer]
English: Ritonavir Cmax and AUCτ ↔ Voriconazole Cmax ↓ 66% Voriconazole AUCτ ↓ 82%
Danish: Ritonavir Cmax og AUCτ ↔ Voriconazol Cmax ↓ 66 % Voriconazol AUCτ ↓ 82 %
English: Co-administration of voriconazole with everolimus is not recommended because voriconazole is expected to significantly increase everolimus concentrations (see section 4.4).
Danish: Samtidig administration af voriconazol og everolimus anbefales ikke, fordi voriconazol antages at øge koncentrationen af everolimus signifikant (se pkt.
English: Voriconazole Hikma 200 mg powder for solution for infusion is for intravenous use only.
Danish: Voriconazole Hikma 200 mg pulver til infusionsvæske, opløsning er kun beregnet til intravenøs anvendelse.
English: Although not studied, carbamazepine and long-acting barbiturates are likely to significantly decrease plasma voriconazole concentrations.
Danish: Selvom det ikke er undersøgt, er det sandsynligt, at carbamazepin og langtidsvirkende benzodiazepiner kan nedsætte plasmakoncentrationerne af voriconazol signifikant.
English: Oral bioavailability may, however, be limited in paediatric patients with malabsorption and very low body weight for their age.
Danish: Hos pædiatriske patienter med malabsorption og meget lav legemsvægt i forhold til deres alder kan den orale biotilgængelighed imidlertid være begrænset.
English: As the half-life of alfentanil is prolonged in a 4-fold manner when alfentanil is coadministered with voriconazole and in an independent published study, concomitant use of voriconazole with fentanyl resulted in an increase in the mean AUC 0-∞ of fentanyl, frequent monitoring for opiate-associated adverse reactions (including a longer respiratory monitoring period) may be necessary.
Danish: Når alfentanil administreres samtidig med voriconazol, forlænges alfentanils halveringstid 4 gange, og i et uafhængigt, publiceret studie resulterede samtidig behandling med voriconazol og fentanyl i en forhøjelse af gennemsnitligt AUC 0-∞ for fentanyl.
English: There have been reports of skin cancer in patients treated with voriconazole for long periods of time
Danish: Der er set tilfælde af hudkræft hos patienter, der blev behandlet med voriconazol igennem længere tid.
English: 300 mg QD (co-administered with voriconazole 350 mg BID)*
Danish: 300 mg QD (administreret sammen med voriconazol 350 mg BID)*
English: 3 Includes nuchal rigidity and tetany.
Danish: 3 Inkluderer nakkestivhed og tetani.
English: 5% Glucose and 0.45% Sodium Chloride Intravenous Infusion 5% Glucose Intravenous Infusion 5% Glucose in 20 mEq Potassium Chloride Intravenous Infusion 0.45% Sodium Chloride Intravenous Infusion 5% Glucose and 0.9% Sodium Chloride Intravenous Infusion
Danish: 5 % glucose i 20 milliækvivalenter kaliumchlorid-infusionsvæske 0,45 % natriumchlorid-infusionsvæske 5 % glucose og 0,9 % natriumchlorid-infusionsvæske
English: • Methadone (used to treat heroin addiction)
Danish: • Methadon (medicin mod heroinmisbrug)
English: Methadone (CYP3A4 substrate)
Danish: Methadon (CYP3A4-substrat)