FrancophonIA/ELRC3.0 huggingface dataset:
English: Novantrone is used in the treatment of: advanced stage (metastatic form) of breast cancer; a form of lymph node cancer (non-Hodgkin's lymphoma); a cancer of the blood in which the bone marrow (the spongy tissue inside the large bones) makes too many white blood cells (acute myeloid leukaemia); a cancer of the white blood cells (chronic myeloid leukaemia) at a stage where it is difficult to control the number of white blood cells (blast crisis).
Croatian: - raka krvi u kojem koštana srž (spužvasto tkivo unutar dugih kostiju) stvara previše bijelih krvnih stanica (akutna mijeloična leukemija); - raka bijelih krvnih stanica (kronične mijeloične leukemije) u stadiju kada se teško kontrolira broj bijelih krvnih stanica (blastična kriza).
English: The recommended initial dosage of mitoxantrone used as a single agent is 14 mg/m2 of body surface area,
Croatian: Preporučeno početno doziranje mitoksantrona primijenjenog u monoterapiji iznosi 14 mg/m2 površine tijela,
English: - Slowed heart beat.
Croatian: - Usporeni otkucaji srca.
English: In metastatic breast cancer, combinations of Novantrone with other cytotoxic agents including cyclophosphamide and 5-fluorouracil or methotrexate and mitomycin C have been shown to be effective.
Croatian: U metastatskom raku dojke pokazale su se učinkovitima kombinacije Novantrona s drugim citotoksičnim lijekovima uključujući ciklofosfamid i 5-fluorouracil ili metotreksat i mitomicin C.
English: Cases of tumour lysis syndrome were reported with the use of mitoxantrone.
Croatian: Slučajevi sindroma lize tumora prijavljeni su pri primjeni mitoksantrona.
English: When pregnant rabbits were treated during organogenesis, an increased incidence of premature delivery was observed at doses > 0.01 times the recommended human dose on an mg/m2 basis.
Croatian: Kada se lijek primijenio na skotnim kunićima tijekom organogeneze, opažena je povećana incidencija prijevremenih okota pri dozama >0,01 puta preporučena doza u ljudi na temelju mg/m2.
English: A complete blood count, including platelets, should be obtained prior to administration of the initial dose of mitoxantrone, 10 days following the administration and prior to each subsequent infusion and in the event that signs and symptoms of infection develop.
Croatian: potrebno je napraviti prije primjene početne doze mitoksantrona, 10 dana nakon primjene i prije svake naknadne infuzije te u slučaju pojave znakova i simptoma infekcije.
English: You must not breast-feed while using mitoxantrone and for up to one month after the last administration.
Croatian: Ne smijete dojiti tijekom primjene mitoksantrona i do jednog mjeseca nakon posljednje primjene.
English: There is no relevant use of mitoxantrone in the paediatric population.
Croatian: Nema relevantne primjene mitoksantrona u pedijatrijskoj populaciji.
English: Mitoxantrone must not be given subcutaneously, intramuscularly, or intra-arterially.
Croatian: Mitoksantron se ne smije davati supkutano, intramuskularno ili intraarterijski.
English: - Swelling (oedema).
Croatian: - Oticanje (edem).
English: - Headache.
Croatian: - Glavobolja.
English: Congestive heart failure Myocardial infarction (including fatal events)
Croatian: Infarkt miokarda (uključujući smrtne ishode)
English: Mitoxantrone has been given as part of combination therapy.
Croatian: Kombinirana terapija Mitoksantron se davao kao dio kombinirane terapije.
English: Anxiety Confusion Paraesthesia Lethargy
Croatian: Anksioznost Konfuzija Parestezija Letargija
English: Advanced castrate-resistant prostate cancer
Croatian: Uznapredovali rak prostate rezistentan na kastraciju
English: Multiple Sclerosis
Croatian: Multipla skleroza
English: A single course of mitoxantrone 6 mg/m2 intravenous (IV) bolus, etoposide 80 mg/m2 intravenous for a period of 1 hour, and cytarabine (Ara-C) 1 g/m2 intravenous for a period of 6 hours daily for 6 days
Croatian: Jednokratni ciklus mitoksantrona 6 mg/m2 intravenski (i.v.) kao bolus, etopozida 80 mg/m2 intravenski tijekom razdoblja od 1 sata i citarabina (Ara-C) 1 mg/m2 intravenski tijekom razdoblja od 6 sati dnevno tijekom 6 dana (MEC) pokazao je antileukemijsku aktivnost kao terapija spasa u refraktornoj AML.
English: Non-metastatic breast cancer
Croatian: Nemetastatski rak dojke
English: Nausea Vomiting
Croatian: Mučnina Povraćanje
English: Mitoxantrone clearance may be reduced by hepatic impairment.
Croatian: Klirens mitoksantrona može biti smanjen zbog oštećenja jetre.
English: Topoisomerase II inhibitors, including mitoxantrone, when used concomitantly with other antineoplastic agents and/or radiotherapy, have been associated with the development of Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndrome (MDS) (see section 4.8).
Croatian: Inhibitori topoizomeraze II, uključujući mitoksantron, povezani su s razvojem akutne mijeloične leukemije (AML) ili mijelodisplastičnog sindroma (MDS) kada se koriste istodobno s drugim antineoplastičnim lijekovima i/ili radioterapijom (vidjeti dio 4.8).
English: How to use Novantrone
Croatian: Kako primjenjivati Novantrone
English: Reproductive system and breast disorders Very common
Croatian: Poremećaji reproduktivnog sustava i dojki Vrlo često
English: - Rash.
Croatian: - Osip.
English: Therefore men under therapy must be advised not to father a child and to use contraceptive measures during and at least 6 months after therapy.
Croatian: Stoga je muškarcima koji primaju terapiju potrebno savjetovati da ne začnu dijete i da koriste kontracepcijske mjere tijekom i najmanje 6 mjeseci nakon terapije.
English: Cardiomyopathy
Croatian: Kardiotoksičnost
English: - Low number of red blood cells which can cause a feeling of tiredness and shortness of breath
Croatian: Nizak broj crvenih krvnih stanica koji može uzrokovati osjećaj umora i nedostatka zraka (anemija).
English: Severe local tissue damage may occur if Novantrone leaks in surrounding tissue (extravasation) during administration.
Croatian: Teška lokalna oštećenja tkiva mogu se pojaviti ako Novantrone istječe u okolno tkivo
English: Sinus bradycardia Electrocardiogram abnormal Left ventricular ejection fraction decreased
Croatian: Sinusna bradikardija Abnormalan elektrokardiogram Smanjena istisna frakcija lijeve klijetke
English: Acute myeloid leukaemia, myelodysplastic syndrome, acute leukaemia
Croatian: Akutna mijeloična leukemija, mijelodisplastični sindrom,
English: Men must not father a child and should use contraceptive measures during and at least 6 months after therapy.
Croatian: Muškarci ne smiju začeti dijete i moraju primijeniti kontracepcijske mjere tijekom i najmanje 6 mjeseci nakon terapije.
English: (myelodysplastic syndrome).
Croatian: (mijelodisplastični sindrom (MDS)).
English: Anxiety Confusion Headache Paraesthesia
Croatian: Anksioznost Konfuzija Glavobolja Parestezija
English: Secondary acute myeloid leukaemia and myelodysplastic syndrome Topoisomerase II inhibitors, including mitoxantrone, when used as monotherapy or especially concomitantly with other antineoplastic agents and/or radiotherapy, have been associated with the development of Acute Myeloid Leukaemia or Myelodysplastic Syndrome.
Croatian: Sekundarna akutna mijeloična leukemija i mijelodisplastični sindrom Inhibitori topoizomeraze II, uključujući mitoksantron, povezani su s razvojem akutne mijeloične leukemije ili mijelodisplastičnog sindroma kada se koriste kao monoterapija ili naročito kada se koriste istodobno s drugim antineoplastičnim lijekovima i/ili radioterapijom.
English: Some side effects could be serious If any of the following happen, tell the doctor immediately: - If your skin becomes pale and you feel weak or experience sudden shortness of breath, this can be sign of a reduction in red blood cells.
Croatian: - ako Vaša koža postane blijeda i osjećate se slabim ili iskusite iznenadni nedostatak zraka, to može biti znak smanjenog broja crvenih krvnih stanica;
English: - Cancer of the white blood cells (acute myeloid leukemia (AML)).
Croatian: - Rak bijelih krvnih stanica (akutna mijeloična leukemija (AML)).
English: Thrombocytopenia Granulocytopenia
Croatian: Trombocitopenija Granulocitopenija
English: A bluish disolouration of the whites of your eyes, skin and nails may also occur.
Croatian: Može se također pojaviti promjena boje bjeloočnica, kože i noktiju u plavkastu.
English: In combination regimens mitoxantrone, in starting doses ranging from 7 to 8 to 10 to 12 mg/m2, dependent on the combination and frequency used, has shown effectiveness.
Croatian: U kombiniranim režimima terapije mitoksantron je pokazao učinkovitost u početnim dozama u rasponu od 7 do 8 do 10 do 12 mg/m2, ovisno o primijenjenoj kombinaciji i učestalosti.
English: - Liver abnormalities.
Croatian: - Abnormalnosti jetre.
English: Fatigue Pyrexia
Croatian: Astenija Umor Pireksija
English: Summary of product characteristics, labelling and package leaflet
Croatian: Sažetak opisa svojstava lijeka, označivanje i uputa o lijeku
English: Medicines that suppress the bone marrow's production of blood cells and platelets (myelosuppressive agents).
Croatian: - lijekovi koji potiskuju proizvodnju krvnih stanica i pločica u koštanoj srži (mijelosupresivne tvari)
English: - Abnormal results of blood tests to check liver and kidney functions (raised aspartate aminotransferase levels, elevated creatinine and urea nitrogen concentration in the blood).
Croatian: - Abnormalni rezultati krvnih pretraga za provjeru jetrenih i bubrežnih funkcija (povećane razine enzima aminotransferaze, povišena koncentracija kreatinina i ureje u krvi).
English: Myelosuppression is a dose-limiting undesirable effect of mitoxantrone.
Croatian: Mijelosupresija je dozom ograničena nuspojava mitoksantrona.
English: • cancer of white blood cells (acute myeloid leukaemia, AML)
Croatian: • rak bijelih krvnih stanica (akutnu mijeloičnu leukemiju, AML)
English: Immune system disorders Uncommon
Croatian: Poremećaji imunološkog sustava
English: Treatment of blast crisis in (chronic) myeloid leukaemia Used alone for recurrence
Croatian: Liječenje blastične krize u (kroničnoj) mijeloičnoj leukemiji
English: - Anxiety.
Croatian: - Tjeskoba.
English: - Infections of the upper airways.
Croatian: - Infekcije gornjih dišnih putova.
English: Women of childbearing potential must be advised to avoid becoming pregnant; should have a negative pregnancy test prior to each dose and use effective contraception during therapy and for at least 4 months after cessation of therapy.
Croatian: Ženama u reproduktivnoj dobi mora se savjetovati da izbjegavaju trudnoću; one trebaju imati negativan test na trudnoću prije svake doze i koristiti učinkovitu kontracepciju tijekom terapije i najmanje 4 mjeseca nakon prestanka terapije.
English: - Abnormal results of blood tests to check liver and kidney functions (elevated creatinine and urea nitrogen concentration in the blood).
Croatian: - Abnormalni rezultati krvnih pretraga za provjeru jetrenih i bubrežnih funkcija (povišena koncentracija kreatinina i ureje u krvi).
English: - Low number of special white blood cells (granulocytes).
Croatian: - Nizak broj posebnih bijelih krvnih stanica (granulocita).
English: If mitoxantrone is administered repeatedly dosing adjustments should be guided by extent and duration of bone marrow suppression.
Croatian: Ako se mitoksantron primjenjuje u više navrata, potrebno je prilagoditi doziranje prema opsegu i trajanju supresije koštane srži.
English: - Tingling sensation.
Croatian: - Osjećaj trnaca.
English: - Low number of special white blood cells (neutrophils).
Croatian: - Nizak broj posebnih bijelih krvnih stanica (neutrofila).
English: o Pain.
Croatian: o Bol.
English: Mitoxantrone
Croatian: mitoksantron
English: - Taste disturbances.
Croatian: - Poremećaji okusa.
English: • a bone marrow disorder that causes abnormally shaped blood cells and leads to leukaemia (myelodysplastic syndrome)
Croatian: • poremećaj koštane srži koji uzrokuje nastanak abnormalno oblikovanih krvnih stanica i dovodi do leukemije (mijelodisplastičnog sindroma)
English: • if you have a low count of a specific type of white blood cells (neutrophils) (less than
Croatian: • ako imate mali broj specifične vrste bijelih krvnih stanica (neutrofila) (manje od 1500 stanica/mm3);
English: Multiple sclerosis population
Croatian: Populacija s multiplom sklerozom
English: Urinary tract infection Upper respiratory tract infection Sepsis
Croatian: Infekcija gornjeg dišnog sustava Sepsa
English: - Mucosal inflammation.
Croatian: - Mukozna upala.
English: basis).
Croatian: MUGA).
English: Women of child-bearing potential should have a negative pregnancy test prior to each dose and must practise effective contraception for at least 4 months after stopping the treatment with Novantrone.
Croatian: Žene u reproduktivnoj dobi trebaju imati negativan test na trudnoću prije svake doze i moraju primjenjivati učinkovitu kontracepciju tijekom najmanje 4 mjeseca nakon prekida liječenja Novantronom.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER [See Annex I - To be completed nationally] {Name and Address} {tel} {fax} {e-mail}
Croatian: Nositelj odobrenja za stavljanje lijeka u promet i proizvođač [Vidjeti Prilog I - ispunjava država članica]
English: - Insufficient production of blood cells in the bone marrow (bone marrow failure).
Croatian: - Nedostatna proizvodnja krvnih stanica u koštanoj srži (zatajenje koštane srži).
English: Novantrone should be administered under the supervision of a doctor experienced in the use of cancer medicines that are toxic to your cells (cytotoxic chemotherapy agents).
Croatian: Upozorenja i mjere opreza Novantrone je potrebno primjenjivati pod nadzorom liječnika s iskustvom u primjeni lijekova protiv raka koji su toksični za Vaše stanice (citotoksični kemoterapeutici).
English: - Low number of special white blood cells (granulocytes and leukocytes).
Croatian: Nizak broj posebnih bijelih krvnih stanica (granulocita i leukocita).
English: As a guide, when mitoxantrone is used in combination chemotherapy with another myelosuppressive agent, the initial dose of mitoxantrone should be reduced by 2 to 4 mg/m2 below the doses recommended for single agent usage; subsequent dosing, as outlined in the table above, depends on the degree and duration of myelosuppression.
Croatian: potrebno je smanjiti početnu dozu mitoksantrona za 2 do 4 mg/m2 ispod doza preporučenih za jednokratnu primjenu lijeka; naknadno doziranje, kao što je navedeno u prethodnoj tablici, ovisi o stupnju i trajanju imunosupresije.
English: Novantrone will be given to you under the supervision of a doctor experienced in the use of cytotoxic chemotherapeutic agents for the treatment of multiple sclerosis.
Croatian: Novantrone će Vam se dati pod nadzorom liječnika s iskustvom u primjeni citotoksičnih kemoterapeutika za liječenje multiple skleroze.
English: Signs and symptoms of infection and differential blood count with WHO grade 1: following dose 9 mg/m² Signs and symptoms of infection and differential blood count with WHO grade 2: following dose 6 mg/m²
Croatian: Diferencijalna krvna slika 7 dana prije infuzije mitoksantrona Znakovi i simptomi infekcije i diferencijalna krvna slika sa stupnjem 1 prema SZO: nakon doze 9 mg/m² Znakovi i simptomi infekcije i diferencijalna krvna slika sa stupnjem 2 prema SZO: nakon doze 6 mg/m² Znakovi i simptomi infekcije i diferencijalna krvna slika sa stupnjem 3 do 4 prema SZO: prekid terapije
English: Haematological support and antimicrobial therapy may be required during prolonged periods of severe myelosuppression.
Croatian: Tijekom produljenih razdoblja teške mijelosupresije mogu biti potrebne hematološka podrška i antimikrobna terapija.
English: Abdominal pain Gastrointestinal haemorrhage Mucosal inflammation Pancreatitis
Croatian: Bol u abdomenu Hemoragija probavnog sustava Mukozna upala
English: Electrocardiogram abnormal Left ventricular ejection fraction decreased
Croatian: Abnormalan elektrokardiogram Smanjena istisna frakcija lijeve klijetke
English: Women of childbearing potential should have a negative pregnancy test prior to each dose, and use effective contraception during therapy and for at least 4 months after cessation of therapy.
Croatian: Žene u reproduktivnoj dobi trebaju imati negativan test na trudnoću prije svake doze i koristiti učinkovitu kontracepciju tijekom terapije i najmanje 4 mjeseca nakon prestanka terapije.
English: Novantrone should be given by slow and freely flowing infusion into the vein.
Croatian: Novantrone je potrebno davati u venu sporom infuzijom uz slobodan protok.
English: Consolidation therapy, which was used in two large randomised multicentre trials, consists of mitoxantrone 12 mg/m2 given by intravenous infusion daily on Days 1 and 2, and cytarabine, 100 mg/m2
Croatian: Konsolidacijska terapija, koja se primijenila u dva velika randomizirana multicentrična ispitivanja, sastoji se od mitoksantrona 12 mg/m2 danog kao intravenska infuzija dnevno 1. i 2. dana, te citarabina 100 mg/m2 danog tijekom 5 dana kao kontinuirana 24-satna infuzija 1. do 5. dana.
English: if you have liver problems; if you have kidney problems; if you have used Novantrone before; if your heart is not working well; if you had prior radiotherapy of the chest; if you already use other medicines that affect your heart; if you had previous therapies with anthracyclines or anthracenediones, such as daunorubicin or doxorubicin; if your bone marrow is not working well (is depressed) or if you are in generally poor health; if you have an infection.
Croatian: - ako imate probleme s jetrom; - ako imate probleme s bubrezima; - ako ste ranije primijenili Novantrone; - ako Vaše srce ne radi dobro; - ako ste ranije primali terapiju prsišta zračenjem;
English: Inhibitors of the BCRP transporter (e.g. eltrombopag, gefitinib) could result in an increased bioavailability.
Croatian: (npr. eltrombopag, gefitinib) mogu rezultirati povećanom bioraspoloživošću.
English: - Abdominal pain.
Croatian: - Bol u abdomenu.
English: The safety of mitoxantrone in patients with renal impairment is not established.
Croatian: Sigurnost mitoksantrona u bolesnika s oštećenjem bubrega nije ustanovljena.
English: The recommended dosage in relapse is 10 to 12 mg/m2 body surface area given as a single intravenous dose daily over 5 consecutive days (total of 50 to 60 mg/m2).
Croatian: Preporučeno doziranje u relapsu iznosi 10 do 12 mg/m2 tjelesne površine, koje se daje kao jednokratna intravenska doza dnevno tijekom 5 uzastopnih dana (ukupno 50 do 60 mg/m2).
English: The treatment with mitoxantrone should be administered under the supervision of a physician experienced in the use of cytotoxic chemotherapeutic agents for the treatment of multiple sclerosis.
Croatian: Liječenje mitoksantronom potrebno je primijeniti pod nadzorom liječnika koji ima iskustvo u primjeni citotoksičnih kemoterapeutika za liječenje multiple skleroze.
English: There have been reports of local/regional neuropathy, some irreversible, following intra-arterial injection.
Croatian: neki od njih ireverzibilni, nakon intraarterijske injekcije.
English: For this reason, patients should be monitored for evidence of cardiac toxicity and questioned about symptoms of heart failure prior to the initiation of and during treatment.
Croatian: Iz tog je razloga prije započinjanja i tijekom trajanja liječenja u bolesnika potrebno pratiti pojavu dokaza kardiotoksičnosti te ih pitati o simptomima zatajenja srca.
English: Acute myeloid leukemia (AML) and Myelodysplastic syndrome A group of anticancer medicines (topoisomerase II inhibitors), including Novantrone, may cause the following diseases when used alone but especially in combination with other chemotherapy and/or radiotherapy:
Croatian: Skupina lijekova protiv raka (inhibitora topoizomeraze II), uključujući Novantrone može uzrokovati sljedeće bolesti kada se primjenjuju samostalno, ali naročito u kombinaciji s drugim kemoterapijama i/ili terapijom zračenjem:
English: In clinical trials cancer patients who received cumulative doses of 140 mg/m either alone or in combination with other chemotherapeutic agents had a cumulative 2.6% probability of clinical congestive heart failure.
Croatian: U kliničkim ispitivanjima bolesnici oboljeli od raka koji su primili kumulativne doze od 140 mg/m2 ili u monoterapiji ili u kombinaciji s drugim kemoterapeuticima imali su kumulativnu vjerojatnost od 2,6% za kliničko kongestivno zatajenje srca.
English: 4.7 Effects on ability to drive and use machines Mitoxantrone has minor influence on the ability to drive and use machines.
Croatian: 4.7 Utjecaj na sposobnost upravljanja vozilima i rada sa strojevima
English: Leukopenia Granulocytopenia White blood cell count abnormal
Croatian: Granulocitopenija Abnormalan broj bijelih krvnih stanica
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Novantrone and associated names (see Annex I) 2 mg/ml concentrate for solution for infusion [See Annex I - To be completed nationally]
Croatian: NAZIV LIJEKA I PUT(EVI) PRIMJENE LIJEKA Novantrone i pridružena imena (vidjeti Prilog I.) 2 mg/ml koncentrat za otopinu za infuziju
English: Do not use Novantrone: if you are allergic to mitoxantrone or any of the other ingredients of this medicine (see section 6); if you are allergic to sulphite; if you have a form of asthma (bronchial asthma) with sulphite allergy; if you are breast-feeding (see section “pregnancy and breast-feeding”).
Croatian: - ako ste alergični na mitoksantron ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.); - ako ste alergični na sulfit;
English: This infection should be treated before taking Novantrone; if you plan a vaccination or immunisation during treatment.
Croatian: Ovu infekciju je potrebno liječiti prije uzimanja Novantrona;
English: Cancer patients who received cumulative doses of 140 mg/m2 either alone or in combination with other chemotherapeutic agents had a cumulative 2.6% probability of clinical congestive heart failure.
Croatian: Bolesnici oboljeli od raka koji su primili kumulativne doze od 140 mg/m2 bilo u monoterapiji ili u kombinaciji s drugim kemoterapeuticima imali su kumulativnu vjerojatnost od 2,6% za kliničko kongestivno zatajenje srca.
English: - Severe itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing), or if you feel you like you are going to faint, these may be signs of severe allergic reaction.
Croatian: - bol u prsištu, nedostatak zraka, promjene u otkucajima srca (brzo ili sporo), zadržavanje tekućine (oticanje) u gležnjevima ili nogama (mogući znakovi ili simptomi srčanih problema); - teški osip koji svrbi (koprivnjača), oticanje ruku, stopala, gležnjeva, lica, usnica, usta ili grla (što može uzrokovati teškoće s gutanjem ili disanjem) ili ako osjećate kao da ćete se onesvijestiti, to mogu biti znakovi teške alergijske reakcije;
English: Pharmacotherapeutic group: Antineoplastic agents, Anthracyclines and related substances ATC-Code: L01DB07
Croatian: ATK oznaka: L01DB07 Mehanizam djelovanja
English: Severe injury with permanent sequelae can result from intrathecal administration.
Croatian: Intratekalna primjena može rezultirati teškom ozljedom s trajnom posljedicom.
English: - Shortness of breath.
Croatian: - Nedostatak zraka.
English: The safety of mitoxantrone in patients with hepatic insufficiency is not established.
Croatian: Oštećenje jetre Sigurnost mitoksantrona u bolesnika s insuficijencijom jetre nije ustanovljena.
English: [To be completed nationally] SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children.
Croatian: POSEBNO UPOZORENJE O ČUVANJU LIJEKA IZVAN POGLEDA
English: In patients receiving oral anticoagulant therapy, the prothrombin time ratio or INR should be closely monitored with the addition and withdrawal of treatment with mitoxantrone and should be reassessed more frequently during concurrent therapy.
Croatian: U bolesnika koji primaju oralnu antikoagulacijsku terapiju potrebno je strogo pratiti omjer protrombinskog vremena ili međunarodni normalizirani omjer (eng.
English: o a bone marrow disorder that causes abnormally shaped blood cells and leads to leukaemia
Croatian: - Abnormalnost koštane srži koja uzrokuje stvaranje abnormalnih krvnih stanica što dovodi do leukemije