FrancophonIA/ELRC3.0 huggingface dataset:
English: If you are going to have an operation, tell your doctor or dentist that you are taking Atacand Plus.
Slovenian: Če imate predvideno kakšno operacijo oz. poseg, morate zdravniku ali zobozdravniku povedati, da jemljete zdravilo Atacand Plus.
English: After administration of a single dose of Atacand Plus, onset of the antihypertensive effect generally occurs within 2 hours.
Slovenian: Po uporabi enkratnega odmerka zdravila Atacand Plus se antihipertenzivni učinek praviloma začne v 2 urah.
English: Amantadine (for the treatment of Parkinson's disease or for serious infections caused by viruses).
Slovenian: • Amantadin (za zdravljenje Parkinsonove bolezni ali resnih virusnih okužb).
English: you are more than 3 months pregnant (it is also better to avoid Atacand Plus in early pregnancy - see pregnancy section).
Slovenian: - če ste noseči več kot 3 mesece (zdravilu Atacand Plus se je bolje izogniti tudi v zgodnji nosečnosti - glejte poglavje o nosečnosti).
English: An increased amount of cholesterol, sugar or uric acid in your blood.
Slovenian: Zvišanje holesterola, sladkorja ali sečne kisline v krvi.
English: Atacand Plus and associated names (see Annex I) 8 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 16 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 32 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 32 mg/25 mg tablets
Slovenian: Atacand Plus in z njim povezana imena (glejte Dodatek I) 8 mg/12,5 mg tablete Atacand Plus in z njim povezana imena (glejte Dodatek I) 16 mg/12,5 mg tablete Atacand Plus in z njim povezana imena (glejte Dodatek I) 32 mg/12,5 mg tablete Atacand Plus in z njim povezana imena (glejte Dodatek I) 32 mg/25 mg tablete
English: Hydrochlorothiazide inhibits the active reabsorption of sodium, mainly in the distal kidney tubules, and promotes the excretion of sodium, chloride and water.
Slovenian: Hidroklorotiazid zavira aktivno reabsorpcijo natrija, predvsem v distalnih ledvičnih tubulih, in spodbuja izločanje natrija, klorida in vode.
English: Candesartan cilexetil/hydrochlorothiazide is similarly effective in patients irrespective of age and gender.
Slovenian: Kombinacija cileksetilkandesartanat/hidroklorotiazid je pri bolnikih podobno učinkovita ne glede na starost in spol.
English: In double-blind, randomised studies, the incidence of adverse events, especially cough, was lower during treatment with Atacand Plus than during treatment with combinations of ACE inhibitors and hydrochlorothiazide.
Slovenian: V dvojno slepih, randomiziranih študijah je bila incidenca neželenih učinkov, zlasti kašlja, manjša med zdravljenjem z zdravilom Atacand Plus kot med zdravljenjem s kombinacijami zaviralcev ACE in hidroklorotiazida.
English: There were no qualitative new toxic findings with the combination compared to that observed for each component.
Slovenian: Med uporabo kombinacije ni bilo kvalitativno novih izsledkov glede toksičnosti v primerjavi z uporabo vsake posamezne sestavine.
English: Therefore the use of Atacand Plus is not recommended in this population.
Slovenian: Zato uporaba zdravila Atacand Plus v tej populaciji ni priporočljiva.
English: Jaundice (yellowing of the skin or the whites of your eyes).
Slovenian: • Zlatenica (porumenelost kože ali očesnih beločnic).
English: Potassium supplements or salt substitutes containing potassium (medicines that increase the amount of potassium in your blood).
Slovenian: • Dodatke kalija ali nadomestke soli, ki vsebujejo kalij (zdravila, ki povečujejo količino kalija v krvi).
English: As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic heart disease or atherosclerotic cerebrovascular disease could result in a myocardial infarction or stroke.
Slovenian: Kot velja za vsa antihipertenzivna zdravila, lahko čezmerno znižanje krvnega tlaka pri bolnikih z ishemično boleznijo srca ali aterosklerotično cerebrovaskularno boleznijo izzove miokardni infarkt ali možgansko kap.
English: Concomitant treatment with baclofen, amifostin, tricyclic antidepressants or neuroleptics may lead to enhancement of the antihypertensive effect and may induce hypotension.
Slovenian: Sočasno zdravljenje z baklofenom, amifostinom, tricikličnimi antidepresivi ali nevroleptiki lahko poveča antihipertenzivni učinek in izzove hipotenzijo.
English: How to store Atacand Plus Further information
Slovenian: Shranjevanje zdravila Atacand Plus Dodatne informacije
English: Hydrochlorothiazide is rapidly absorbed from the gastrointestinal tract with an absolute bioavailability of approximately 70%.
Slovenian: Hidroklorotiazid se hitro absorbira iz prebavil in njegova absolutna biološka uporabnost je približno 70 %.
English: 6.6 Special precautions for disposal and other handling No special requirements
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom Ni posebnih zahtev.
English: In two studies, both including patients with mild to moderate hepatic impairment, there was an increase in the mean AUC of candesartan of approximately 20% in one study and 80% in the other study (see section 4.2).
Slovenian: V dveh študijah, ki sta obe zajeli bolnike z blago do zmerno okvaro jeter, so v eni študiji ugotovili povečanje povprečne AUC kandesartana za približno 20 % in v drugi za približno 80 % (glejte poglavje 4.2).
English: • Candesartan cilexetil belongs to a group of medicines called angiotensin II receptor antagonists.
Slovenian: • Cileksetilkandesartanat spada v skupino zdravil, imenovanih antagonisti receptorjev angiotenzina II.
English: Very rarely, hypotension may be severe such that it may warrant the use of intravenous fluids and/or vasopressors.
Slovenian: Zelo redko je lahko hipotenzija tako huda, da mora bolnik dobiti intravensko tekočino in/ali vazopresorska zdravila.
English: Marked hypercalcaemia may be a sign of hidden hyperparathyroidism.
Slovenian: Izrazita hiperkalciemija je lahko znak prikritega hiperparatiroidizma.
English: The renal excretion of potassium and magnesium increases dose-dependently, while calcium is reabsorbed to a greater extent.
Slovenian: Ledvično izločanje kalija in magnezija se povečuje od odmerka odvisno, kalcij pa se reabsorbira v večji meri.
English: Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Slovenian: Če nadaljnje zdravljenje z ARAII ni nujno, je treba bolnice, ki načrtujejo nosečnost, prevesti na druga antihipertenzivna zdravila, ki imajo ugotovljen boljši varnostni profil med nosečnostjo.
English: When driving vehicles or operating machines, it should be taken into account that occasionally dizziness or weariness may occur during treatment with Atacand Plus.
Slovenian: Pri vožnji in upravljanju s stroji je treba upoštevati, da se lahko med zdravljenjem z zdravilom Atacand Plus občasno pojavi omotica ali utrujenost.
English: Other medicines that may lead to enhancement of the antihypertensive effect such as baclofen (a medicine for relief of spasticity), amifostin (used in cancer treatment) and some antipsychotic medicines.
Slovenian: • Druga zdravila, ki lahko povečajo antihipertenzivni učinek, npr. baklofen (zdravilo za ublažitev spastičnosti), amifostin (uporablja se za zdravljenje raka) ali nekatere antipsihotike.
English: Monitoring of potassium should be undertaken as appropriate (see section 4.4).
Slovenian: Koncentracijo kalija je treba kontrolirati, kot je primerno (glejte poglavje 4.4).
English: Atacand Plus is contraindicated in patients with severe hepatic impairment and/or cholestasis (see section 4.3).
Slovenian: Zdravilo Atacand Plus je kontraindicirano pri bolnikih s hudo okvaro jeter in/ali s holestazo (glejte poglavje 4.3).
English: you have severe liver disease or biliary obstruction (a problem with the drainage of bile from the gall bladder).
Slovenian: - če imate hudo bolezen jeter ali biliarno obstrukcijo (to je motnja odtekanja žolča iz žolčnika).
English: The plasma protein binding of hydrochlorothiazide is approximately 60%.
Slovenian: Vezava hidroklorotiazida na beljakovine v plazmi je približno 60 %.
English: The effects of candesartan cilexetil 8-16 mg (mean dose 12 mg) once daily on cardiovascular morbidity and mortality were evaluated in a randomised clinical trial with 4,937 elderly patients (aged 70-89 years, 21% aged 80 or above) with mild to moderate hypertension followed for a mean of 3.7 years (Study on COgnition and Prognosis in the Elderly).
Slovenian: Učinke odmerkov od 8 do 16 mg cileksetilkandesartanata (povprečni odmerek 12 mg) enkrat na dan na kardiovaskularno obolevnost in umrljivost so ocenili v randomiziranem kliničnem preskušanju 4.937 starejših bolnikov (starih od 70 do 89 let, 21 % starih 80 let ali več) z blago do zmerno hipertenzijo; bolnike so spremljali povprečno 3.7 leta (študija SCOPE; Study on COgnition and Prognosis in the Elderly).
English: Candesartan and hydrochlorothiazide have additive antihypertensive effects.
Slovenian: Kandesartan in hidroklorotiazid imata aditivne antihipertenzivne učinke.
English: swelling of the face, lips, tongue and/or throat, which may cause difficulties in swallowing.
Slovenian: • oteklost obraza, ustnic, jezika in/ali žrela, ki lahko povzroči težave pri požiranju.
English: Hydrochlorothiazide may cause the arterial response to pressor amines (e.g. adrenaline) to decrease but not enough to exclude a pressor effect.
Slovenian: Hidroklorotiazid lahko zmanjša arterijski odziv na presorske amine (npr. adrenalin), vendar ne v tolikšni meri, da bi odpravil presorski učinek.
English: When AIIRAs are administered simultaneously with non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Slovenian: Če so ARAII uporabljeni sočasno z nesteroidnimi protivnetnimi zdravili (NSAID) (tj. selektivnimi zaviralci COX-2, acetilsalicilno kislino (> 3 g/dan) ali neselektivnimi nesteroidnimi protivnetnimi zdravili), se lahko antihipertenzivni učinek zmanjša.
English: you have severe kidney problems.
Slovenian: - če imate hude težave z ledvicami.
English: Marketing Authorisation Holder and Manufacturer [See Annex I - To be completed nationally] {Name and address of the manufacturer} {tel} {fax} {e-mail}
Slovenian: Imetnik dovoljenja za promet in izdelovalec [Glejte Dodatek I - izpolni država članica] {Ime in naslov izdelovalca} {tel.} {faks} {e-pošta}
English: Data from in vitro and in vivo genotoxicity testing indicate that candesartan and hydrochlorothiazide are unlikely to exert any mutagenic or clastogenic activity under conditions of clinical use.
Slovenian: Podatki testiranja genotoksičnosti in vitro in in vivo kažejo, da ni verjetno, da bi kandesartan in hidroklorotiazid v pogojih klinične uporabe delovala mutageno ali klastogeno.
English: Periodic monitoring of serum potassium is recommended when Atacand Plus is administered with such medicinal products, and with the following medicinal products that could induce torsades de pointes:
Slovenian: Redne kontrole kalija v serumu so priporočljive, če je zdravilo Atacand Plus uporabljeno s takšnimi zdravil ter z naslednjimi zdravili, ki lahko izzovejo torsades de pointes:
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING CARTON FOR BLISTER / CARTON FOR BOTTLE / LABEL FOR BOTTLE
Slovenian: PODATKI NA ZUNANJI OVOJNINI NA PRIMARNI OVOJNINI ŠKATLA ZA PRETISNI OMOT / ŠKATLA ZA STEKLENIČKO / NALEPKA ZA STEKLENIČKO
English: Thiazides in high doses causing intense diuresis can inhibit the milk production.
Slovenian: Tiazidi v visokih odmerkih povzročajo intenzivno diurezo in lahko zavrejo nastajanje mleka.
English: The relative bioavailability of a tablet formulation of candesartan cilexetil compared with the same oral solution is approximately 34% with very little variability.
Slovenian: Relativna biološka uporabnost tablet cileksetilkandesartanata je v primerjavi z isto peroralno raztopino približno 34 % in kaže zelo majhno variabilnost.
English: The following measures are, however, suggested in case of overdose.
Slovenian: A v primeru prevelikega odmerjanja je predlagano ukrepanje naslednje.
English: Hypersensitivity to the active substances or to any of the excipients or to sulfonamide derived active substances.
Slovenian: Preobčutljivost za zdravilni učinkovini, katerokoli pomožno snov ali katerokoli sulfonamidno zdravilno učinkovino.
English: Hydrochlorothiazide is not metabolised and is excreted almost entirely as unchanged drug by glomerular filtration and active tubular secretion.
Slovenian: Hidroklorotiazid se ne presnovi in se izloči skoraj izključno kot nespremenjeno zdravilo z glomerularno filtracijo in aktivno tubularno sekrecijo.
English: Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Slovenian: Preobčutljivostne reakcije na hidroklorotiazid se lahko pojavijo tako pri bolnikih z anamnezo alergije ali bronhialne astme kot pri bolnikih brez takšne anamneze, vendar so pri bolnikih s takšno anamnezo verjetnejše.
English: If this is severe then you may notice weakness, lack of energy, or muscle cramps.
Slovenian: Če je to znižanje hudo, lahko občutite šibkost, pomanjkanje energije ali mišične krče.
English: If you stop taking Atacand Plus, your blood pressure may increase again.
Slovenian: Če ste prenehali jemati zdravilo Atacand Plus Če prenehate jemati zdravilo Atacand Plus, se vam krvni tlak lahko spet zviša.
English: you have ever had a disease called systemic lupus erythaematosus (SLE) you have low blood pressure you have ever had a stroke.
Slovenian: - če ste kdaj imeli bolezen, imenovano sistemski eritematozni lupus - če imate nizek krvni tlak.
English: [See Annex I - To be completed nationally] candesartan cilexetil/hydrochlorothiazide
Slovenian: [Glejte Dodatek I - izpolni država članica] cileksetilkandesartanat/hidroklorotiazid
English: The table below presents adverse reactions with hydrochlorothiazide monotherapy usually with doses of 25 mg or higher.
Slovenian: Spodnja preglednica navaja neželene učinke monoterapije s hidroklorotiazidom, po navadi z odmerkih 25 mg ali več.
English: If you take more Atacand Plus than you should If you take more Atacand Plus than prescribed by your doctor, contact a doctor or pharmacist immediately for advice.
Slovenian: Če ste vzeli večji odmerek zdravila Atacand Plus, kot bi smeli Če ste vzeli več zdravila Atacand Plus, kot vam ga je predpisal zdravnik, se nemudoma posvetujte z zdravnikom ali s farmacevtom.
English: If you are not sure if any of these apply to you, talk to your doctor or pharmacist before taking Atacand Plus.
Slovenian: Če niste prepričani, ali kaj od tega velja za vas, se posvetujte z zdravnikom ali s farmacevtom, preden vzamete zdravilo Atacand Plus.
English: In elderly subjects (over 65 years), Cmax and AUC of candesartan are increased by approximately 50% and 80%, respectively in comparison to young subjects.
Slovenian: Pri starejših osebah (nad 65 let) se Cmax v primerjavi z mladimi osebami poveča za približno 50 %, AUC pa za približno 80 %.
English: Summary of product characteristics
Slovenian: POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA
English: In controlled clinical trials comparing candesartan cilexetil with ACE inhibitors, the incidence of cough was lower in patients receiving candesartan cilexetil.
Slovenian: V kontroliranih kliničnih preskušanjih, ki so primerjala kandesartan z zaviralci ACE, je bila incidenca kašlja manjša pri bolnikih, ki so prejemali cileksetilkandesartanat.
English: The risk for hypokalaemia may be increased in patients with cirrhosis of the liver, in patients experiencing brisk diuresis, in patients with an inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or adrenocorticotropic hormone (ACTH).
Slovenian: Tveganje hipokaliemije se lahko poveča pri bolnikih s cirozo jeter, bolnikih, ki se jim pojavi hitra diureza, bolnikih, ki ne uživajo dovolj elektrolitov, in tistih, ki sočasno dobivajo kortikosteroide ali adrenokortikotropni hormon (ACTH).
English: In hypertensive patients, Atacand Plus results in a dose-dependent and long-lasting reduction in arterial blood pressure without reflex increase in heart rate.
Slovenian: Pri hipertenzivnih bolnikih zdravilo Atacand Plus od odmerka odvisno in dolgotrajno zniža arterijski krvni tlak brez refleksnega povečanja srčne frekvence.
English: This effect of hydrochlorothiazide seems to be less evident when combined with candesartan cilexetil.
Slovenian: Kaže, da je ta učinek hidroklorotiazida manj opazen med kombinirano uporabo s cileksetilkandesartanatom.
English: Thiazides may reduce the renal excretion of cytotoxic medicinal products (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Slovenian: Tiazidi lahko zmanjšajo ledvično izločanje citotoksičnih zdravil (npr. ciklofosfamida, metotreksata) in povečajo njihove mielosupresivne učinke.
English: Breathing difficulties (including lung inflammation and fluid in the lungs).
Slovenian: • Težko dihanje (vključno z vnetjem pljuč in tekočino v pljučih).
English: Currently there are no data on the use of candesartan cilexetil/hydrochlorothiazide in patients with renal disease/nephropathy, reduced left ventricular function/congestive heart failure and post myocardial infarction.
Slovenian: Trenutno ni podatkov o uporabi cileksetilkandesartanata/hidroklorotiazida pri bolnikih z boleznijo ledvic/nefropatijo, zmanjšanim delovanjem levega prekata/srčnim popuščanjem ali po miokardnem infarktu.
English: Anticholinergic agents such as atropine and biperiden.
Slovenian: • Antiholinergična zdravila, kakršni sta npr. atropin in biperiden.
English: Cases of photosensitivity reactions have been reported during use of thiazide diuretics (see section 4.8).
Slovenian: Med uporabo tiazidnih diuretikov so poročali o fotosenzibilnostnih reakcijah (glejte poglavje 4.8).
English: Treatment with a thiazide diuretic may impair glucose tolerance.
Slovenian: Zdravljenje s tiazidnim diuretikom lahko poslabša toleranco za glukozo.
English: Thiazides should be discontinued before carrying out tests for parathyroid function.
Slovenian: Tiazide je treba nehati uporabljati pred preiskavami delovanja obščitnic.
English: Use of candesartan and hydrochlorothiazide with lithium is not recommended.
Slovenian: Uporaba kandesartana in hidroklorotiazida skupaj z litijem ni priporočljiva.
English: cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperiodol)
Slovenian: ciamemazin, sulpirid, sultoprid, amisulprid, tiaprid, pimozid, haloperidol, droperidol).
English: Candesartan caused a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit).
Slovenian: Kandesartan je povzročil zmanjšanje eritrocitnih parametrov (eritrociti, hemoglobin, hematokrit).
English: Concomitant treatment with cyclosporine may increase the risk of hyperuricaemia and gout-type complications.
Slovenian: Sočasno zdravljenje s ciklosporinom lahko poveča tveganje hiperurikemije in zapletov protinske vrste.
English: Candesartan can not be removed by haemodialysis.
Slovenian: Kandesartana ni mogoče odstraniti s hemodializo.
English: Anticholinergic agents (e.g. atropine, biperiden) may increase the bioavailability of thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate.
Slovenian: Antiholinergiki (npr. atropin, biperiden) lahko povečajo biološko uporabnost tiazidnih diuretikov, ker zmanjšajo gastrointestinalno motiliteto in hitrost praznjenja želodca.
English: Treatment with candesartan cilexetil may cause hyperkalaemia, especially in the presence of heart failure and/or renal impairment.
Slovenian: Zdravljenje s cileksetilkandesartanatom lahko povzroči hiperkaliemijo, zlasti če ima bolnik srčno popuščanje in/ali okvaro ledvic.
English: Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Slovenian: Pri bolnikih z okvarjenim delovanjem jeter ali progresivno boleznijo jeter je treba tiazide uporabljati previdno, kajti že majhne spremembe ravnovesja tekočine in elektrolitov lahko sprožijo jetrno komo.
English: If this happens to you, contact your doctor immediately.
Slovenian: Če se to zgodi, se morate nemudoma posvetovati z zdravnikom.
English: These work together to lower your blood pressure.
Slovenian: Ti skupaj pomagata znižati krvni tlak.
English: • Treatment of essential hypertension in adult patients whose blood pressure is not optimally controlled with candesartan cilexetil or hydrochlorothiazide monotherapy.
Slovenian: • zdravljenje esencialne hipertenzije pri odraslih bolnikih, ki krvnega tlaka nimajo optimalno urejenega z monoterapijo s cileksetilkandesartanatom ali hidroklorotiazidom.
English: A severe rash, that develops quickly, with blistering or peeling of the skin and possibly blistering in the mouth.
Slovenian: • Hud izpuščaj, ki nastane hitro in ga spremlja nastajanje mehurjev ali lupljenje kože in lahko tudi nastajanje mehurjev v ustih.
English: The use of AIIRAs is not recommended during the first trimester of pregnancy (see section 4.4).
Slovenian: ARAII ni priporočljivo uporabljati v prvem trimesečju nosečnosti (glejte poglavje 4.4).
English: Compounds which have been investigated in clinical pharmacokinetic studies include warfarin, digoxin, oral contraceptives (i.e. ethinylestradiol/levonorgestrel), glibenclamide and nifedipine.
Slovenian: Med učinkovinami, ki so jih raziskali v kliničnih farmakokinetičnih študijah, so varfarin, digoksin, peroralni kontraceptivi (tj. etinilestradiol/levonorgestrel), glibenklamid in nifedipin.
English: Difficulty in sleeping, depression, being restless.
Slovenian: • Težave s spanjem, depresija, nemir.
English: Addition of hydrochlorothiazide potentiates the nephrotoxicity of candesartan.
Slovenian: Dodatek hidroklorotiazida poveča nefrotoksičnost kandesartana.
English: Hydrochlorothiazide decreases plasma volume and extracellular fluid and reduces cardiac output and blood pressure.
Slovenian: Hidroklorotiazid zmanjša volumen plazme in zunajcelične tekočine ter minutni volumen srca in krvni tlak.
English: In patients with intravascular volume and/or sodium depletion symptomatic hypotension may occur, as described for other agents acting on the renin-angiotensin-aldosterone system.
Slovenian: Bolnikom s pomanjkanjem intravaskularnega volumna in/ali pomanjkanjem natrija se lahko pojavi simptomatska hipotenzija, tako kot je opisano pri drugih zdravilih, ki delujejo na sistem reninangiotenzin-aldosteron.
English: Atacand Plus can be taken with or without food.
Slovenian: • Zdravilo Atacand Plus lahko vzamete s hrano ali brez nje.
English: What Atacand Plus looks like and contents of the pack [To be completed nationally]
Slovenian: Izgled zdravila Atacand Plus in vsebina pakiranja [Izpolni država članica]
English: If this is not sufficient, plasma volume should be increased by infusion of isotonic saline solution.
Slovenian: Če to ne zadošča, je treba povečati volumen plazme z infuzijo, npr. z infuzijo fiziološke raztopine.
English: There is no clinically significant interaction between hydrochlorothiazide and food.
Slovenian: Med hidroklorotiazidom in hrano ni klinično pomembnih interakcij.
English: Medicinal products that affect the renin-angiotensin-aldosterone system, including angiotensin II receptor antagonists (AIIRAs), may increase blood urea and serum creatinine in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.
Slovenian: Zdravila, ki vplivajo na sistem renin-angiotenzin-aldosteron, vključno z antagonisti receptorjev angiotenzina II (ARAII), lahko pri bolnikih z bilateralno stenozo ledvične arterije ali stenozo arterije ene same ledvice povečajo koncentracijo sečnine v krvi in kreatinina v serumu.