FrancophonIA/ELRC3.0 huggingface dataset:
English: An existing intravenous line should be flushed with sodium chloride 9 mg/mL (0.9%) solution for injection or 50 mg/mL (5%) dextrose solution.
Croatian: Postojeću intravensku liniju treba ispirati 0,9%-tnom (9 mg/mL) otopinom natrijevog klorida za injekciju ili 5%-tnom (50 mg/mL) otopinom glukoze.
English: Daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantrone, topotecan concentrations may increase.
Croatian: Koncentracije daunorubicina, doksorubicina, imatiniba, irinotekana, lapatiniba, mitoksantrona i topotekana se mogu povećati.
English: adjustment if required.
Croatian: OD LIJEKA, AKO JE POTREBNO
English: Cyclophosphamide concentrations may decrease.
Croatian: Koncentracije ciklofosfamida mogu se smanjiti.
English: Based on these findings, intravenous and oral dosing can be used interchangeably.
Croatian: Na temelju ovih rezultata, moguć je prelazak s intravenskog na oralno doziranje, i obrnuto.
English: Isavuconazole is extensively distributed, with a mean steady state volume of distribution (Vss) of approximately 450 L. Isavuconazole is highly bound (> 99%) to human plasma proteins, predominantly to albumin.
Croatian: Izavukonazol se u velikoj mjeri veže (> 99%) na proteine ljudske plazme, prije svega na albumin.
English: Cyclophosphamide: careful monitoring for any occurrence of lack of efficacy, and dose increase if required..
Croatian: Ciklofosfamid: pažljivo praćenje radi mogućeg izostanka djelotvornosti i po potrebi povećanje doze.
English: The use of the CYP2B6 substrate efavirenz with CRESEMBA is contraindicated because efavirenz is a moderate inducer of CYP3A4/5 (see section 4.3).
Croatian: Primjena supstrata CYP2B6 efavirenza s lijekom CRESEMBA je kontraindicirana, jer je efavirenz umjereni induktor CYP3A4/5 (vidjeti dio
English: Isavuconazole : AUCtau : ↓ 90% Cmax : ↓ 75%
Croatian: Izavukonazol: AUCtau: ↓ 90% Cmax: ↓ 75%
English: - Printing ink: shellac, propylene glycol, potassium hydroxide, black iron oxide (E172).
Croatian: - Tinta za označavanje: šelak, propilenglikol, kalijev hidroksid, željezov oksid crni (E172).
English: (CYP2B6 induction)
Croatian: (indukcija CYP2B6)
English: One vial of the powder for concentrate for solution for infusion should be reconstituted by addition of 5 mL water for injections to the vial.
Croatian: Jednu bočicu praška za koncentrat za otopinu za infuziju potrebno je rekonstituirati dodavanjem 5 mL vode za injekcije u bočicu.
English: EUCAST MIC breakpoints are defined for the following species (susceptible S; resistant R):
Croatian: Prema EUCAST-u (European Committee on Antimicrobial Susceptibility Testing) granične vrijednosti minimalnih inhibitornih koncentracija (MIK) utvrđene su za sljedeće vrste (S - osjetljiva; Rrezistentna):
English: Breast-feeding should be discontinued during treatment with CRESEMBA.
Croatian: Tijekom terapije lijekom CRESEMBA dojenje treba prekinuti.
English: Short-acting opiates (alfentanyl, fentanyl) (CYP3A4/5 substrate)
Croatian: Opijati s kratkotrajnim djelovanjem (alfentanil, fentanil) (supstrat za CYP3A4/5)
English: CRESEMBA is also available as hard capsules containing 100 mg isavuconazole, equivalent to 186 mg isavuconazonium sulfate.
Croatian: CRESEMBA je dostupna i u obliku tvrdih kapsula koje sadrže 100 mg izavukonazola, što odgovara količini od 186 mg izavukonazonijevog sulfata.
English: CYP3A4/5 substrates including immunosuppressants
Croatian: Supstrati CYP3A4/5 uključujući imunosupresive
English: Other protease inhibitors (e.g., amprenavir, nelfinavir) (CYP3A4/5 strong or moderate inhibitors and substrates)
Croatian: Drugi inhibitori proteaze (npr. amprenavir, nelfinavir) (jaki ili umjereni inhibitori i supstrati za CYP3A4/5)
English: Other NNRTI (e.g., delavirdine, and nevirapine) (CYP3A4/5 and 2B6 inducers and substrates)
Croatian: Drugi NNRTI (npr. delavirdin i nevirapin) (Induktori i supstrati za CYP3A4/5 i 2B6)
English: One vial of the powder for concentrate for solution for infusion should be reconstituted by addition of 5 mL water for injection to the vial.
Croatian: Jednu bočicu praška za koncentrat za otopinu za infuziju potrebno je rekonstituirati dodavanjem 5 mL vode za injekciju u bočicu.
English: Benzodiazepines Midazolam (CYP3A4/5 substrate)
Croatian: Benzodiazepini Midazolam (supstrat za CYP3A4/5)
English: The concomitant administration of CRESEMBA and ketoconazole is contraindicated.
Croatian: Istodobna primjena lijeka CRESEMBA i ketokonazola je kontraindicirana.
English: The recommended loading dose is one vial after reconstitution and dilution (equivalent to 200 mg of isavuconazole) every 8 hours for the first 48 hours (6 administrations in total).
Croatian: Preporučena udarna doza je jedna bočica nakon rekonstitucije i razrjeđivanja (što odgovara količini od 200 mg izavukonazola) svakih 8 sati u prvih 48 sati (ukupno 6 primjena).
English: Co-administration of medicinal products which are inducers of CYP3A4 and/or CYP3A5 may decrease the plasma concentrations of isavuconazole.
Croatian: Istodobna primjena lijekova koji su induktori CYP3A4 i/ili CYP3A5 može sniziti koncentracije izavukonazola u plazmi.
English: Talk to your doctor, pharmacist or nurse before using Cresemba: - if you have had an allergic reaction to other ‘azole' anti-fungal treatments in the past, such as ketoconazole, fluconazole, itraconazole, voriconazole or posaconazole, - if you are suffering from severe liver disease.
Croatian: Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego primite lijek Cresemba: - ako ste ranije imali alergijsku reakciju na druge “azolne” lijekove protiv gljivica poput ketokonazola, flukonazola, itrakonazola, vorikonazola ili posakonazola, - ako bolujete od teške bolesti jetre.
English: Co-administered medicinal product by therapeutic area
Croatian: Istodobno primijenjeni lijekovi prema terapijskom području
English: Antiarrhythmics Digoxin (P-gp substrate)
Croatian: Antiaritmici Digoksin (Supstrat za P-gp)
English: Smoking cessation aids Bupropion (CYP2B6 substrate)
Croatian: Lijekovi kao pomoć za prestanak pušenja Bupropion (supstrat za CYP2B6)
English: (P-gp inhibition).
Croatian: (Inhibicija P-gp).
English: CRESEMBA 100 mg hard capsules
Croatian: CRESEMBA 100 mg tvrde kapsule
English: Co-administration of medicinal products which are inhibitors of CYP3A4 and/or CYP3A5 may increase the plasma concentrations of isavuconazole.
Croatian: Istodobna primjena lijekova koji su inhibitori CYP3A4 i/ili CYP3A5 može povećati koncentracije izavukonazola u plazmi.
English: Intravenous administration of
Croatian: Intravenska primjena
English: Isavuconazole: AUCtau: ↑ 8% Cmax: ↑ 5%
Croatian: Izavukonazol: AUCtau: ↑ 8% Cmax: ↑ 5%
English: Efavirenz concentrations may decrease.
Croatian: Koncentracije efavirenza mogu se smanjiti.
English: Blister for 100 mg hard capsules
Croatian: Blister za tvrde kapsule od 100 mg
English: Ethinyl oestradiol AUCinf: ↑ 8% Cmax: ↑ 14%
Croatian: Etinilestradiol AUCinf: ↑ 8% Cmax: ↑ 14% Noretindron
English: Isavuconazole: AUCtau: ↑ 422% Cmax: ↑ 9%
Croatian: Izavukonazol: AUCtau: ↑ 422% Cmax: ↑ 9%
English: Isavuconazole is a moderate inhibitor of CYP3A4/5; co-administration of CRESEMBA with medicinal products which are substrates of CYP3A4/5 may result in increased plasma concentrations of these medicinal products.
Croatian: Izavukonazol je umjereni inhibitor CYP3A4/5; istodobna primjena lijeka CRESEMBA s lijekovima koji su supstrati za CYP3A4/5 može rezultirati povećanim koncentracijama tih lijekova u plazmi.
English: Each capsule contains 186.3 mg isavuconazonium sulfate, corresponding to 100 mg isavuconazole.
Croatian: Jedna kapsula sadrži 186,3 mg izavukonazonijevog sulfata što odgovara količini od 100 mg izavukonazola.
English: Efavirenz (CYP3A4/5 moderate inducer and CYP2B6 substrate)
Croatian: Efavirenz (umjereni induktor za CYP3A4/5 i supstrat za CYP2B6)
English: What Cresemba looks like and contents of the pack Cresemba 200 mg is presented in a single use glass vial as a powder for concentrate for solution for infusion.
Croatian: Cresemba 200 mg dostavlja se u staklenoj bočici za jednokratnu uporabu, kao prašak za koncentrat za otopinu za infuziju.
English: Isavuconazole is a mild inhibitor of P-glycoprotein (P-gp); co-administration with CRESEMBA may result in increased plasma concentrations of P-gp substrates.
Croatian: Izavukonazol je slab inhibitor P-glikoproteina (P-gp); istodobna primjena s lijekom CRESEMBA može rezultirati povećanim koncentracijama supstrata za P-gp u plazmi.
English: Indinavir: careful monitoring for any occurrence of lack of antiviral efficacy, and dose increase if required.
Croatian: Indinavir: pažljivo praćenje radi mogućeg izostanka djelotvornosti i po potrebi povećanje doze.
English: Antitussives Dextromethorphan (CYP2D6 substrate)
Croatian: Dekstrometorfan (supstrat za CYP2D6)
English: Carbamazepine, phenobarbital and phenytoin (strong CYP3A4/5 inducers)
Croatian: Karbamazepin, fenobarbital i fenitoin (snažni induktori CYP3A4/5)
English: No dose adjustment of CRESEMBA is necessary when co-administered with strong CYP3A4/5 inhibitors, however caution is advised as adverse drug reactions may increase (see section 4.4).
Croatian: Nije potrebna prilagodba doze lijeka CRESEMBA kada se primjenjuje istodobno sa snažnim inhibitorima CYP3A4/5, međutim preporučuje se oprez, jer se nuspojave na lijek mogu pojačati (vidjeti dio 4.4).
English: Co-administration of CRESEMBA with potent CYP3A4/5 inducers such as rifampicin, rifabutin, carbamazepine, long-acting barbiturates (e.g., phenobarbital), phenytoin and St. John's wort, or with moderate CYP3A4/5 inducers such as efavirenz, nafcillin and etravirine, is contraindicated, since these medicinal products can significantly decrease plasma concentrations of isavuconazole (see section 4.3).
Croatian: Istodobna primjena lijeka CRESEMBA sa snažnim induktorima CYP3A4/5 poput rifampicina, rifabutina, karbamazepina, barbiturata s dugotrajnim djelovanjem (npr. fenobarbital), fenitoina i gospine trave ili s umjerenim induktorima CYP3A4/5, poput efavirenza, nafcilina i etravirina je kontraindicirana jer ti lijekovi mogu značajno smanjiti koncentracije izavukonazola u plazmi (vidjeti dio 4.3).
English: (BCRP inhibition)
Croatian: (Inhibicija BCRP-a)
English: No dose adjustment of CRESEMBA is necessary when coadministered with strong CYP3A4/5 inhibitors, however caution is advised as adverse drug reactions may increase (see section 4.5).
Croatian: Nije potrebno prilagođavati dozu lijeka CRESEMBA kada se primjenjuje istodobno sa snažnim inhibitorima CYP3A4/5, međutim preporučuje se oprez, jer se nuspojave na lijek mogu povećati (vidjeti dio 4.5).
English: Omeprazole:
Croatian: Omeprazol:
English: Cyclophosphamide (CYP2B6 substrate)
Croatian: Ciklofosfamid (supstrat za CYP2B6)
English: Isavuconazole: AUCtau: ↑ 96% Cmax: ↑ 74%
Croatian: Izavukonazol: AUCtau: ↑ 96% Cmax: ↑ 74%
English: If you think you have been given too much Cresemba, talk to your doctor or nurse straight away.
Croatian: Ako primite više lijeka Cresemba nego što ste trebali Ako mislite da ste primili previše lijeka Cresemba, odmah razgovarajte s liječnikom ili medicinskom sestrom.
English: CYP2B6 substrates
Croatian: Supstrati CYP2B6
English: What you need to know before you take Cresemba 3.
Croatian: Što morate znati prije nego počnete primati lijek Cresemba 3.
English: How to take Cresemba
Croatian: Kako uzimati lijek Cresemba
English: Further information regarding the storage conditions after reconstitution and dilution of the medicinal product is provided in section 6.3.
Croatian: Dodatne informacije o uvjetima čuvanja lijeka nakon rekonstitucije i razrjeđivanja navedene su u dijelu 6.3.
English: Co-administration with strong CYP3A4/5 inducers such as rifampicin, rifabutin, carbamazepine, longacting barbiturates (e.g. phenobarbital), phenytoin and St. John's wort or with moderate CYP3A4/5 inducers such as efavirenz, nafcillin and etravirine (see section 4.5).
Croatian: Istodobna primjena sa snažnim induktorima CYP3A4/5 poput rifampicina, rifabutina, karbamazepina, barbiturata s dugotrajnim djelovanjem (npr. fenobarbital), fenitoina i gospine trave ili s umjerenim induktorima CYP3A4/5 poput efavirenza, nafcilina i etravirina (vidjeti dio 4.5).
English: Cmax (ng/mL) Mean
Croatian: Cmax (ng/mL) Srednja vrijednost SD
English: hair loss, - back pain, - swelling of the extremities, - feeling weak, very tired, or sleepy or generally out of sorts (malaise).
Croatian: (dermatitis), gubitak kose, - bol u leđima, - oticanje udova, - osjećaj slabosti, jakog umora i pospanosti te opća slabost (malaksalost).
English: Printing ink shellac propylene glycol potassium hydroxide black iron oxide (E172)
Croatian: Tinta za označavanje šelak propilenglikol kalijev hidroksid željezov oksid, crni (E172)
English: Stop taking Cresemba and tell your doctor straight away if you notice any of the following side effects: - rash, swelling of your lips, mouth, tongue or throat with difficulty breathing - these may be signs of an allergic reaction (hypersensitivity).
Croatian: Prekinite uzimanje lijeka Cresemba i odmah se obratite liječniku ako primijetite neku od sljedećih nuspojava: - osip, oticanje usana, usta, jezika ili grla uz otežano disanje - to mogu biti znakovi alergijske reakcije (preosjetljivosti).
English: Esomeprazole (CYP2C19 substrate and gastric pH )
Croatian: Esomeprazol (supstrat za CYP2C19 i želučani pH ↑)
English: CRESEMBA 100 mg hard capsules Isavuconazole
Croatian: CRESEMBA 100 mg tvrde kapsule izavukonazol
English: Stop using Cresemba and tell your doctor straight away if you notice any of the following side effects: - rash, swelling of your lips, mouth, tongue or throat with difficulty breathing - these may be signs of an allergic reaction (hypersensitivity).
Croatian: Prekinite primjenu lijeka Cresemba i odmah se obratite liječniku ako primijetite neku od sljedećih nuspojava: - osip, oticanje usana, usta, jezika ili grla uz otežano disanje - to mogu biti znakovi alergijske reakcije (preosjetljivosti).
English: (CYP3A4 induction).
Croatian: (Indukcija CYP3A4).
English: Protease inhibitors: careful monitoring for any occurrence of drug toxicity and /or lack of antiviral efficacy, and dose adjustment if required.
Croatian: Inhibitori proteaze: pažljivo praćenje radi mogućeg razvoja toksičnosti lijeka i/ili izostanka antivirusne djelotvornosti te po potrebi prilagođavanje doze.
English: If you forget to take Cresemba
Croatian: Ako ste zaboravili uzeti lijek Cresemba
English: Storage conditions after reconstitution and dilution are provided in section 6.3.
Croatian: Uvjeti čuvanja lijeka nakon rekonstitucije i razrjeđivanja navedeni su u dijelu 6.3.
English: Each hard capsule contains 100 mg isavuconazole (as 186.3 mg isavuconazonium sulfate)
Croatian: Jedna tvrda kapsula sadrži 100 mg izavukonazola (u obliku 186,3 mg izavukonazonijevog sulfata)
English: Isavuconazole can be considered a moderate inhibitor of CYP3A4/5, and systemic exposure to medicinal products metabolised by CYP3A4 may be increased when co-administered with CRESEMBA.
Croatian: Izavukonazol se može smatrati umjerenim inhibitorom CYP3A4/5, a sistemska izloženost lijekovima koji se metaboliziraju putem CYP3A4 može se povećati kada se istodobno primjenjuju s lijekom CRESEMBA.
English: You may have more side effects such as: - headache, feeling dizzy, restless or sleepy, - tingling, reduced sense of touch or sensation in the mouth, - problems being aware of things, hot flushes, anxiety, joint pain, - changes in the way things taste, dry mouth, diarrhoea, vomiting, - feeling your heart beat, faster heart rate, being more sensitive to light.
Croatian: Možete primijetiti više nuspojava kao što su: - glavobolja, omaglica, nemir ili pospanost, - trnci, smanjenje osjeta dodira ili osjeta u ustima, - problemi s poimanjem stvari, navale vrućine, tjeskoba, bolovi u zglobovima, - promjena osjeta okusa hrane, suhoća usta, proljev, povraćanje, - osjećaj lupanja srca, ubrzan pols, povećana osjetljivost na svjetlost.
English: (CYP3A4/5 or BCRP inhibition)
Croatian: (Inhibicija CYP3A4/5 i BCRP)
English: NNRTIs: careful monitoring for any occurrence of drug toxicity and/or lack of anti-viral efficacy, and dose adjustment if required.
Croatian: NNRTI-ovi: pažljivo praćenje radi mogućeg razvoja toksičnosti lijeka i/ili izostanka antivirusne djelotvornosti te po potrebi prilagođavanje doze.
English: Anticonvulsants
Croatian: Antikonvulzivi
English: Medicinal products that inhibit CYP3A4/5
Croatian: Lijekovi koji inhibiraju CYP3A4/5
English: If you stop using Cresemba
Croatian: Ako prestanete primjenjivati lijek Cresemba
English: General disorders and administration site conditions Common Chest pain^; Fatigue; Injection site reaction^ Uncommon Oedema peripheral;^ Malaise; Asthenia
Croatian: Opći poremećaji i reakcije na mjestu primjene često bol u prsima^; umor; reakcija na mjestu injekcije^ manje često periferni edem^; malaksalost; astenija
English: Omeprazole (CYP2C19 substrate and gastric pH )
Croatian: Omeprazol (supstrat za CYP2C19 i želučani pH ↑)
English: Look out for side effects
Croatian: Pazite na nuspojave
English: - cyclophosphamide, used for cancer, - digoxin, used to treat heart failure or an uneven heart beat, - colchicine, used for gout attack, - dabigatran etexilate, used to stop blood clots after hip or knee replacement surgery, - clarithromycin, used for bacterial infections, - saquinavir, amprenavir, nelfinavir, indinavir, delavirdine, nevirapine, lopinavir/ritonavir combination, used for HIV, - alfentanil, fentanyl, used against strong pain, - vincristine, vinblastine, used for cancer, - mycophenolate mofetil (MMF), used in transplant patients, - midazolam, used for severe insomnia and stress, - bupropion, used for depression, - metformin, used for diabetes, - daunorubicin, doxorubicin, imatinib, irinotecan, lapatinib, mitoxantrone, topotecan, used for different sorts of cancer.
Croatian: “imunosupresivi”, - ciklofosfamid, za liječenje raka, - digoksin, za liječenje zatajenja srca ili neujednačenih otkucaja srca, - kolhicin, za napadaje gihta, - dabigatraneteksilat, za sprječavanje stvaranja krvnih ugrušaka nakon kirurškog zahvata zamjene kuka ili koljena, - klaritromicin za liječenje bakterijskih infekcija. - sakvinavir, amprenavir, nelfinavir, indinavir, delavirdin, nevirapin, kombinacija lopinavir/ritonavir, za liječenje HIV-a, - alfentanil, fentanil, protiv jakih bolova, - vinkristin, vinblastin, za liječenje raka, - mofetilmikofenolat (MMF), za bolesnike kojima je obavljena transplantacija, - midazolam, za liječenje teških oblika nesanice i stresa, - bupropion, za liječenje depresije. - metformin, za liječenje dijabetesa, - daunorubicin, doksorubicin, imatinib, irinotekan, lapatinib, mitoksantron i topotekan za liječenje različitih vrsta raka.
English: Skin problems Tell your doctor straight away if you get severe blistering of the skin, mouth, eyes or genitals.
Croatian: Odmah se obratite liječniku ako na koži, u ustima, očima ili na spolnim organima primijetite jako stvaranje mjehura.
English: The concomitant administration of CRESEMBA and rifabutin is contraindicated.
Croatian: Istodobna primjena lijeka CRESEMBA i rifabutina je kontraindicirana.
English: The concomitant administration of CRESEMBA and etravirine is contraindicated.
Croatian: Istodobna primjena lijeka CRESEMBA i etravirina je kontraindicirana.
English: Each capsule contains 100 mg isavuconazole (as 186.3 mg isavuconazonium sulfate).
Croatian: Jedna kapsula sadrži 100 mg izavukonazola (u obliku 186,3 mg izavukonazonijevog sulfata).
English: Nafcillin (moderate CY3A4/5 inducer)
Croatian: Nafcilin (umjereni induktor CY3A4/5)
English: Rifabutin (strong CYP3A4/5 inducer)
Croatian: Rifabutin (snažan induktor CYP3A4/5)
English: Recommendation concerning co-administration
Croatian: Preporuka o istodobnoj primjeni
English: The concomitant administration of CRESEMBA and rifampicin is contraindicated.
Croatian: Istodobna primjena lijeka CRESEMBA i rifampicina je kontraindicirana.
English: Medicinal products that induce CYP3A4/5
Croatian: Lijekovi koji induciraju CYP3A4/5
English: hair loss, - back pain, - feeling weak, very tired, or sleepy or generally out of sorts (malaise).
Croatian: (dermatitis), gubitak kose, - bol u leđima, - osjećaj slabosti, jakog umora i pospanosti te opća slabost (malaksalost).
English: Ketoconazole (strong CYP3A4/5 inhibitor)
Croatian: Ketokonazol (snažan inhibitor CYP3A4/5)
English: What you need to know before you take Cresemba
Croatian: Što morate znati prije nego počnete uzimati lijek Cresemba
English: Clarithromycin (strong CYP3A4/5 inhibitor)
Croatian: Klaritromicin (snažan inhibitor CYP3A4/5)
English: Saquinavir: careful monitoring for any occurrence of drug toxicity and /or lack of anti-viral efficacy, and dose adjustment if required
Croatian: Sakvinavir: pažljivo praćenje radi mogućeg razvoja toksičnosti lijeka i/ili izostanka antivirusne djelotvornosti te po potrebi prilagođavanje doze
English: (P-gp inhibition)
Croatian: (Inhibicija P-gp)
English: Severe hepatic impairment
Croatian: Teške nuspojave na koži
English: For storage conditions after reconstitution and dilution of the medicinal product, see section 6.3.
Croatian: Za detalje o uvjetima čuvanja lijeka nakon rekonstitucije i razrjeđivanja vidjeti dio 6.3.
English: Repaglinide: no dose adjustment required.
Croatian: Repaglinid: nije potrebna prilagodba doze.
English: SD
Croatian: D.
English: Pfizer ΕΛΛΑΣ A.E. Τηλ: +30 210 67 85 800
Croatian: Τηλ: +30 210 67 85 800
English: Co-administration with mild CYP3A4/5 inducers such as aprepitant, prednisone and pioglitazone, may result in mild to moderate decreases of isavuconazole plasma levels; co-administration with mild CYP3A4/5 inducers should be avoided unless the potential benefit is considered to outweigh the risk (see section 4.4).
Croatian: Istodobna primjena sa slabim induktorima CYP3A4/5 poput aprepitanta, prednizona i pioglitazona, može rezultirati blagim do umjerenim smanjenjem razina izavukonazola u plazmi, stoga istodobnu primjenu sa slabim induktorima CYP3A4/5 treba izbjegavati osim ako bi potencijalna korist nadmašila rizike (vidjeti dio 4.4).
English: Methadone: no dose adjustment required.
Croatian: Metadon: prilagodba doze nije potrebna.
English: Caffeine: no dose adjustment required.
Croatian: Kofein: nije potrebna prilagodba doze.
English: Cresemba 200 mg powder for concentrate for solution for infusion Isavuconazole
Croatian: CRESEMBA 200 mg prašak za koncentrat za otopinu za infuziju izavukonazol
English: In particular, do not take this medicine and tell your doctor or pharmacist if you are taking any of the following medicines: - ketoconazole, used for fungal infections, - high doses of ritonavir (400 mg every 12 hours), used for HIV, - rifampicin, rifabutin, used for tuberculosis, - carbamazepine, used for epilepsy, - barbiturate medicines like phenobarbital, used for epilepsy and sleep disorders, - phenytoin, used for epilepsy, - St John's wort, a herbal medicine used for depression.
Croatian: Naročito, nemojte uzimati ovaj lijek i obavijestite svog liječnika ili ljekarnika ako uzimate neki od sljedećih lijekova: - ketokonazol, za liječenje gljivičnih infekcija, - visoke doze ritonavira (400 mg svakih 12 sati), za liječenje HIV-a, - rifampicin, rifabutin za liječenje tuberkuloze, - karbamazepin za liječenje epilepsije, - barbiturate poput fenobarbitala za liječenje epilepsije i poremećaja spavanja, - fenitoin za liječenje epilepsije, - gospinu travu, biljni lijek za depresiju.
English: Cardiovascular
Croatian: Kardiovaskularne reakcije
English: Each vial contains 200 mg isavuconazole (as 372.6 mg isavuconazonium sulfate)
Croatian: Jedna bočica sadrži 200 mg izavukonazola (u obliku 372,6 mg izavukonazonijevog sulfata)
English: Dilution and administration
Croatian: Razrjeđivanje i primjena
English: AUC (h•ng/mL) Mean
Croatian: AUC (h•ng/mL) Srednja vrijednost SD
English: Each vial contains 200 mg isavuconazole (as 372.6 mg isavuconazonium sulfate).
Croatian: Jedna bočica sadrži 200 mg izavukonazola (u obliku 372,6 mg izavukonazonijevog sulfata).
English: CRESEMBA 200 mg powder for concentrate for solution for infusion
Croatian: CRESEMBA 200 mg prašak za koncentrat za otopinu za infuziju
English: Saquinavir (strong CYP3A4 inhibitor)
Croatian: Sakvinavir (snažan inhibitor CYP3A4)