FrancophonIA/ELRC3.0 huggingface dataset:
English: If eye exposure occurs, the eye should be flushed with plenty of water for 15 minutes.
Croatian: Ukoliko oko bude izloženo, oko treba ispirati obilnom količinom vode 15 minuta.
English: The administration of sevoflurane must be individualised based on the dog's or cat's response.
Croatian: Primjena sevoflurana mora biti individualizirana na temelju odgovora pojedinog psa ili mačke.
English: The colour indicator of most CO2 absorbents does not necessarily change as a result of desiccation.
Croatian: Boja indikatora većine apsorbera CO2 ne mijenja se nužno kao rezultat sušenja.
English: There are limited data to support the safety of sevoflurane in animals less than 12 weeks of age.
Croatian: Podaci koji pokazuju neškodljivost sevoflurana u životinja mlađih od 12 tjedana su ograničeni.
English: Direct exposure to eyes may result in mild irritation.
Croatian: Izravno izlaganje očima može rezultirati blagom nadraženošću.
English: Seek medical attention if irritation persists.
Croatian: Potrebno je potražiti liječničku pomoć ukoliko nadraženost potraje.
English: Since the reaction of carbon dioxide with absorbents is exothermic, this temperature increase will be determined by the quantities of CO2 absorbed, which in turn will depend on fresh gas flow in the anaesthetic circle system, metabolic status of the dog and ventilation.
Croatian: Budući da je reakcija ugljikovog dioksida s apsorberima egzotermička, to povećanje temperature bit će određeno količinom apsorbiranog CO2, što će pak ovisiti o protoku svježeg plina kroz anestetički kružni sustav, metaboličkom statusu psa i ventilaciji.
English: Sevoflurane is compatible with phenothiazines and alpha-2-agonists commonly used in veterinary practice.
Croatian: Sevofluran je kompatibilan s fenotiazinima i alfa-2-agonistima, koji se često koriste u veterinarskoj praksi.
English: SevoFlo should be administered via a vaporiser specifically calibrated for use with sevoflurane so that the concentration delivered can be accurately controlled.
Croatian: SevoFlo treba primijeniti putem isparivača posebno kalibriranog za uporabu sa sevofluranom, tako da se dostavljena koncentracija može točno kontrolirati.
English: Rare cases of excessive heat production, smoke and/or fire in the anaesthetic machine have been reported during the use of a desiccated CO2 absorbent and sevoflurane.
Croatian: Zabilježeni su rijetki slučajevi pretjerane proizvodnje topline, dima i/ili vatre u anesteziološkim strojevima tijekom uporabe osušenog apsorbera CO2 i sevoflurana.
English: TARGET SPECIES Dogs and cats.
Croatian: CILJNE VRSTE ŽIVOTINJA Psi i mačke
English: Limited clinical experience in administering sevoflurane to animals with renal, hepatic and cardiovascular insufficiency suggests that sevoflurane may be safely used in these conditions.
Croatian: Ograničeno kliničko iskustvo u primjeni sevoflurana u životinja s bubrežnom, jetrenom i kardiovaskularnom insuficijencijom ukazuje na to da se sevofluran može sigurno koristiti u tim stanjima.
English: The nephrotoxic potential of certain NSAIDs, when used in the perioperative period, may be exacerbated by hypotensive episodes during sevoflurane anaesthesia.
Croatian: Mogućnost nefrotoksičnih učinaka nekih nesteroidnih protuupalnih lijekova, kad se koriste u perioperacijskom razdoblju, može biti povećana hipotenzivnim epizodama tijekom anestezije sevofluranom.
English: Anaesthetic induction is correspondingly rapid and the depth of anaesthesia changes rapidly with changes in anaesthetic concentration.
Croatian: Uvođenje u anesteziju jednako je brzo i dubina anestezije brzo se mijenja s promjenama koncentracije anestetika.
English: Fluoride ion concentrations are influenced by the duration of anaesthesia and the concentration of sevoflurane.
Croatian: Koncentracije iona fluorida pod utjecajem su trajanja anestezije i koncentracije sevoflurana.
English: Serum fluoride fell quickly after anaesthesia ended and had returned to baseline by 24 hours post-anaesthesia.
Croatian: Serumski fluorid brzo se snizio nakon prestanka anestezije i vratio na početnu vrijednost u roku od 24 sata nakon anestezije.
English: In cats sevoflurane has been shown to exert some neuromuscular blocking effect, but this is only apparent at high doses.
Croatian: Kod mačaka je pokazano da sevofluran ima neki neuromuskularni blokirajući učinak, ali to je vidljivo samo pri visokim dozama.
English: Sevoflurane administration is compatible with the intravenous barbiturates and propofol and in cats alfaxalone and ketamine.
Croatian: Sevofluran je kompatibilan s intravenskim barbituratima i propofolom a u mačaka alfaksalonom i ketaminom.
English: In cats, transient increases in AST and ALT may occur with sevoflurane, however, hepatic enzymes tend to remain within the normal range.
Croatian: Kod mačaka može se pojaviti prolazno povećanje AST i ALT kod primjene sevoflurana, međutim, enzimi jetre obično ostaju unutar normalnog raspona.
English: The administration of general anaesthesia must be individualised based on the dog's or cat's response.
Croatian: Primjena opće anestezije mora biti individualizirana na temelju odgovora pojedinog psa ili mačke.
English: Therefore, it should only be used in these animals according to a benefit-risk assessment by the responsible veterinary surgeon.
Croatian: Stoga njegova primjena na tim životinjama treba biti u skladu s procjenom odnosa koristi/rizika od strane odgovornog veterinara.
English: • Avoid using masking procedures for prolonged induction and maintenance of general anaesthesia.
Croatian: • Izbjegavajte uporabu postupaka s maskom za dugotrajnije uvođenje u anesteziju i održavanje opće anestezije.
English: Interaction with other veterinary medicinal products and other forms of interaction
Croatian: Interakcije s drugim veterinarsko-medicinskim proizvodima i drugi oblici interakcija Intravenski anestetici:
English: During sevoflurane induction, there is a rapid increase in alveolar concentration towards the inspired concentration, with the ratio of inspired to end-tidal concentration of sevoflurane reaching a value of 1 within 10 minutes.
Croatian: Tijekom uvođenja u anesteziju sevofluranom, alveolarna koncentracija brzo se povećava prema udahnutoj koncentraciji, s time da omjer udahnute koncentracije sevoflurana i koncentracije na kraju izdisaja postiže vrijednost 1 u roku od 10 minuta.
English: In humans sevoflurane increases both the intensity and duration of neuromuscular blockade induced by nondepolarising muscle relaxants.
Croatian: U ljudi uporaba sevoflurana povećava intenzitet i trajanje neuromuskularne blokade inducirane nedepolarizirajućim mišićnim relaksansima.
English: The use of sevoflurane with nondepolarising muscle relaxants has not been evaluated in dogs.
Croatian: Uporaba sevoflurana i nedepolarizirajućih mišićnih relaksansa nije se procjenjivala u pasa.
English: In cases of severe cardiopulmonary depression, discontinue sevoflurane administration, ensure the existence of a patent airway and initiate assisted or controlled ventilation with pure oxygen.
Croatian: U slučajevima teške kardiopulmonalne depresije, primjenu sevoflurana treba prekinuti, osigurati prohodnost dišnih puteva i započeti s asistiranom ili kontroliranom ventilacijom čistim kisikom.
English: In dogs exposed to 4% sevoflurane for 3 hours, mean peak maximum serum fluoride concentrations of 20.0 ± 4.8 µmol/l have been observed after 3 hours of anaesthesia.
Croatian: U pasa izloženih koncentraciji sevoflurana od 4% tijekom 3 sata, prosječne vršne koncentracije fluorida primijećene u serumu iznosile su 20.0 ± 4.8 µmol/l nakon 3 sata anestezije.
English: Studies in dogs and cats show that anticholinergic premedication is compatible with sevoflurane anaesthesia in dogs and cats.
Croatian: Ispitivanja u pasa i mačaka pokazala su da je premedikacija antikolinergicima kompatibilna sa anestezijom sevofluranom u pasa i mačaka.
English: Nevertheless, renal oxygen consumption, and hence renal function, are preserved at mean arterial pressures above 60 mmHg in dogs and cats.
Croatian: Ipak, potrošnja kisika u bubregu, a time i funkcija bubrega, očuvani su pri prosječnom arterijskom tlaku većem od 60 mmHg u pasa i mačaka.
English: An unusual decrease in the expected depth of anaesthesia compared to the vaporiser setting may indicate excessive heating of the CO2 absorbent canister.
Croatian: Neobično smanjenje očekivane dubine anestezije u odnosu na postavke isparivača može ukazivati na pretjerano zagrijavanje kanistra s CO2 apsorberom.
English: It may be reversed by administration of anticholinergics.
Croatian: To se može poništiti davanjem antikolinergika.
English: In dogs, transient elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), bilirubin and white blood cell counts may occur with sevoflurane, as with the use of other halogenated anaesthetic agents.
Croatian: U pasa, prilikom primjene sevoflurana može se pojaviti prolazno povećanje aspartat aminotransferaze (AST), alanin aminotransferaze (ALT), laktat dehidrogenaze (LDH), bilirubina i broja bijelih krvnih zrnaca , kao i kod uporabe drugih halogeniranih anestetika.
English: Surgical levels of anaesthesia in the healthy dog may be maintained with inhaled concentrations of 3.3 to 3.6% in the presence of premedication.
Croatian: Kirurška razina anestezije u zdravih pasa može se održati uz udisanje koncentracije od 3,3 do 3,6% nakon premedikacije.
English: If eye exposure occurs, wash with plenty of water for 15 minutes.
Croatian: U slučaju da oko bude izloženo, treba ga ispirati obilnom količinom vode 15 minuta.
English: In the cat surgical anaesthesia is maintained with sevoflurane concentrations of 3.7-4.5%.
Croatian: U kirurškoj anesteziji mačaka održava se koncentracija sevoflurana od 3,7 - 4,5%.
English: A minimal amount of sevoflurane is required to be dissolved in the blood before the alveolar partial pressure is in equilibrium with the arterial partial pressure because of the low solubility of sevoflurane in blood (blood/gas partition coefficient at 30°C is 0.63 to 0.69).
Croatian: Potrebno je da samo minimalna količina sevoflurana bude otopljena u krvi prije nego što se postigne ravnoteža između alveolarnog parcijalnog tlaka i arterijskog parcijalnog tlaka, zato što je sevofluran slabo topljiv u krvi (koeficijent raspodjele krv/plin pri temperaturi od 30 °C iznosi
English: Although Compound A is a dose-dependent nephrotoxin in rats, the mechanism of this renal toxicity is unknown.
Croatian: Premda je Spoj A nefrotoksičan ovisno o dozi u štakora, mehanizam ove bubrežne toksičnosti nije poznat.
English: Due to sevoflurane's low solubility in blood, increasing the concentration may result in rapid haemodynamic changes (dose-dependent decreases in blood pressure) compared to other volatile anaesthetics.
Croatian: Zbog niske topljivosti sevoflurana u krvi, povećanje njegove koncentracije može izazvati brze hemodinamske promjene (sniženje arterijskog tlaka ovisno o dozi) u usporedbi s drugim hlapljivim anesteticima.
English: Longduration, low-flow sevoflurane anaesthesia should be avoided due to the risks of Compound A accumulation.
Croatian: Dugotrajnu anesteziju niskim protokom sevoflurana treba izbjegavati zbog rizika od nakupljanja Spoja A.
English: In dogs with head injuries or other conditions placing them at risk from increased ICP, it is recommended that hypocapnia be induced by means of controlled hyperventilation as a means of preventing changes in ICP.
Croatian: U pasa i mačaka s ozljedama glave ili drugim stanjima kod kojih postoji rizik od povećanja intrakranijalnog tlaka preporučuje se izazivanje hipokapnije pomoću kontrolirane hiperventilacije kao načina sprječavanja promjene intrakranijalnog tlaka.
English: Sevoflurane may cause a small increase in intracranial pressure (ICP) under conditions of normocapnia in dogs.
Croatian: Sevofluran može izazvati malo povećanje intrakranijalnog tlaka u uvjetima normokapnije u pasa.
English: Due to sevoflurane's low solubility in blood, these haemodynamic changes may occur more rapidly than with other volatile anaesthetics.
Croatian: Zbog slabe topljivosti sevoflurana u krvi, ove hemodinamske promjene mogu nastati brže nego uz druge hlapljive anestetike.
English: Excessive decreases in blood pressure or respiratory depression may be corrected by decreasing or discontinuing the inspired concentration of sevoflurane.
Croatian: Pretjerano smanjenje arterijskog tlaka ili respiratorna depresija mogu se ispraviti smanjenjem ili prekidom udisanja koncentracije sevoflurana.
English: In common with all volatile agents, sevoflurane may cause hypotension in hypovolaemic animals such as those requiring surgery to repair traumatic injury, and lower doses should be administered in combination with appropriate analgesics.
Croatian: Isto kao i druge hlapljiva tvari, sevofluran može uzrokovati hipotenziju kod hipovolemičnih životinja kao što su one koje zahtijevaju operaciju zbog traumatskih ozljeda, a niže doze treba davati u kombinaciji s odgovarajućim analgeticima.
English: The necessity for and choice of premedication is left to the discretion of the veterinarian.
Croatian: Potreba za premedikacijom i izbor lijekova za premedikaciju prepušteni su slobodnoj odluci veterinara.
English: Administer by inhalation using a vaporiser calibrated for sevoflurane.
Croatian: Primijeniti udisanjem pomoću isparivača kalibriranog za sevofluran.
English: In order to maintain renal blood flow, prolonged episodes of hypotension (mean arterial pressure below 60 mmHg) should be avoided in dogs and cats during sevoflurane anaesthesia.
Croatian: Da bi se održao protok krvi kroz bubreg, treba izbjegavati produljene epizode hipotenzije (prosječni arterijski tlak manji od 60 mmHg) u pasa i mačaka tijekom anestezije sevofluranom.
English: Sevoflurane has a variable effect on heart rate, which tends to increase from baseline at low MAC and fall back with increasing MAC. Sevoflurane causes systemic vasodilation and produces dosedependent decreases in mean arterial pressure, total peripheral resistance, cardiac output and possibly the strength of myocardial contraction and speed of myocardial relaxation.
Croatian: Sevofluran izaziva sistemsku vazodilataciju i ovisno o dozi izaziva smanjenje prosječnog arterijskog tlaka, ukupne periferne rezistencije, srčanog minutnog volumena i moguće jačine kontrakcije miokarda i brzine relaksacije miokarda.
English: SevoFlo is presented in a cardboard box containing a 250 ml polyethylene naphthalate (PEN) bottle with a Quik-Fil closure.
Croatian: SevoFlo je pakiran u boci od polietilen naftalata (PEN) od 250 ml sa Quik-Fil zatvaračem, u kartonskoj kutiji.
English: As a result, renal blood flow falls in a linear fashion with increasing hypotension in sevoflurane anaesthetised dogs and cats.
Croatian: Rezultat toga je da protok krvi kroz bubrega opada na linearan način s povećanjem hipotenzije u pasa i mačaka anesteziranih sevofluranom.
English: Special precautions to be taken by the person administering the veterinary medicinal product to animals
Croatian: Posebne mjere predostrožnost koje mora poduzeti osoba koja primjenjuje veterinarsko- medicinski proizvod na životinjama
English: In order to minimise this reaction in rebreathing anaesthetic circuits, SevoFlo should not be passed through soda lime or barium hydroxide that has been allowed to dry out.
Croatian: Da bi se smanjila ova reakcija u ciklusu ponovnog udisanja anestetika, SevoFlo se ne smije propuštati kroz smjesu kalcijevog, natrijevog i kalijevog hidroksida ili barijev hidroksida koji su se osušili.
English: If malignant hyperthermia develops, the anaesthetic supply should be interrupted immediately and 100% oxygen administered using fresh anaesthetic hoses and a rebreathing bag.
Croatian: Ako se razvije maligna hipertermija, odmah se mora prekinuti dostava anestetika i primijeniti 100%-tni kisik kroz nove anestetičke cijevi i balon za povratno disanje.
English: For mask induction using sevoflurane, inspired concentrations of 5 to 7% sevoflurane with oxygen are employed to induce surgical anaesthesia in the healthy dog, and 6 to 8% sevoflurane with oxygen in the cat.
Croatian: Za uvođenje u anesteziju pomoću maske, udahnute koncentracije sevoflurana od 5 - 7% s kisikom koji se koriste da bi se inducirala kirurška anestezija u zdravih pasa i 6 - 8% sevoflurana s kisikom u mačaka.
English: Excessive decreases in blood pressure or respiratory depression may be related to the depth of anaesthesia and may be corrected by decreasing the inspired concentration of sevoflurane.
Croatian: Pretjerano sniženje arterijskog tlaka ili respiratorna depresija mogu biti povezane s dubinom anestezije i mogu se ispraviti smanjenjem koncentracije sevoflurana koji se udiše.
English: For operator warnings - read the package leaflet before use.
Croatian: Upozorenje za operatera - pročitati uputu o VMP prije primjene.
English: These concentrations can be expected to produce surgical anaesthesia within 3 to 14 minutes in dogs and within 2 to 3 minutes in cats.
Croatian: Očekuje se da će takve koncentracije izazvati kiruršku anesteziju u roku od 3 do 14 minuta u pasa te unutar 2 do 3 minute u mačaka.
English: STATEMENT OF ACTIVE SUBSTANCES 100% sevoflurane
Croatian: 100% sevofluran
English: Maintenance of anaesthesia:
Croatian: Održavanje anestezije:
English: Symptoms of human overexposure (inhalation) to sevoflurane vapours include respiratory depression, hypotension, bradycardia, shivering, nausea and headache.
Croatian: Simptomi pretjeranog izlaganja (udisanja) ljudi parama sevoflurana uključuju respiratornu depresiju, hipotenziju, bradikardiju, tremor, mučninu i glavobolju.
English: Reaction with barium hydroxide results in a greater production of Compound A than does the reaction with soda lime.
Croatian: Reakcija s barijevim hidroksidom rezultira većom proizvodnjom Spoja A
English: Limited data are available on the effects of the highly potent alpha-2agonists (medetomidine, romifidine and dexmedetomidine) as premedication.
Croatian: Dostupni su ograničeni podaci o učincima visoko potentnih alfa-2-agonista (medetomidina,romifidina i deksmedetomidina) u premedikaciji, koji se stoga moraju koristiti s oprezom.
English: However, there is limited clinical experience of the use of sevoflurane, after propofol induction, in bitches and queens undergoing caesarean section, without any ill effects being detected in either the bitch or queen or the puppies or kittens.
Croatian: Međutim, postoji ograničeno kliničko iskustvo uporabe sevoflurana nakon uvođenja u anesteziju propofolom kod kuja i mački u kojih će se raditi carski rez, bez ikakvih primjetnih štetnih učinaka na kuji i mački te štencima ili mačićima.
English: Anticholinergics:
Croatian: Antikolinergici:
English: Parent compound (the dominant fraction) is eliminated via the lungs.
Croatian: Ishodni spoj (najveća frakcija) eliminira se putem pluća.
English: Do not use in animals with known hypersensitivity to sevoflurane or other halogenated anaesthetic agents.
Croatian: Ne primjenjivati na životinjama s poznatom preosjetljivošću na sevofluran ili druge halogenirane anestetike.
English: The exothermic reaction that occurs between inhalation agents (including sevoflurane) and CO2 absorbents is increased when the CO2 absorbent becomes desiccated, such as after an extended period of dry gas flow through the CO2 absorbent canisters.
Croatian: Egzotermička reakcija koja nastaje između inhalacijskih sredstava (uključujući sevofluran) i apsorbera CO2 povećana je kad apsorber CO2 postane suh, kao što bude nakon produljenog razdoblja protoka suhog plina kroz kanistre apsorbera CO2.
English: The concentration of sevoflurane necessary to maintain anaesthesia is less than that required for induction.
Croatian: Koncentracija sevoflurana neophodna da bi se održala anestezija manja je od one koja je potrebna za uvođenje u anesteziju.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGE BOTTLE
Croatian: PODACI NA UNUTARNJEM PAKOVANJU BOČICA
English: Halogenated volatile anaesthetics can react with dry carbon dioxide (CO2) absorbents to produce carbon monoxide (CO) that may result in elevated levels of carboxyhaemoglobin in some dogs.
Croatian: Halogenirani hlapljivi anestetici mogu reagirati sa suhim apsorberima ugljičnog dioksida (CO2) pri čemu se stvara ugljični monoksid (CO), što može rezultirati povišenim razinama karboksihemoglobina u nekih pasa.
English: Sevoflurane may be used for maintenance anaesthesia following mask induction using sevoflurane or following induction with injectable agents.
Croatian: Sevofluran se može koristiti za održavanje anestezije nakon uvođenja u anesteziju pomoću sevoflurana kroz masku ili pomoću lijekova koji se ubrizgavaju.
English: The safety of the veterinary medicinal product has not been established during pregnancy or lactation.
Croatian: Neškodljivost primjene ovog veterinarsko - medicinskog proizvoda nije utvrđena tijekom graviditeta ili laktacije.
English: Dose-dependent respiratory depression is commonly observed while using sevoflurane, therefore respiration should be closely monitored during sevoflurane anaesthesia and the inspired concentration of sevoflurane adjusted accordingly.
Croatian: Tijekom primjene sevoflurana, često je opažena respiratorna depresija ovisna o dozi, pa se tijekom anestezije sevofluranom disanje mora strogo nadzirati, a udahnuta koncentracija sevoflurana prilagoditi sukladno tome.
English: The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
Croatian: Neškodljivost primjene ovog veterinarsko - medicinskog proizvoda nije utvrđena tijekom graviditeta i laktacije.
English: Bradycardia can be reversed by the administration of anticholinergics.
Croatian: Bradikardija se pokazala reverzibilnom nakon primjene antikolinergika.
English: In dogs, the concurrent administration of thiopental, however, may slightly increase sensitivity to adrenaline-induced cardiac arrhythmias.
Croatian: U pasa, istodobna primjena tiopentala, međutim, može blago povećati osjetljivost na srčane aritmije izazvane adrenalinom.
English: Advice to doctors: Maintain a patent airway and give symptomatic and supportive treatment.
Croatian: Održavati prohodnost dišnih puteva i dati simptomatsko i potporno liječenje.
English: Anaesthetic regimens that include opioid, alpha-2-agonist, benzodiazepine or phenothiazine premedication will allow the use of lower sevoflurane maintenance concentrations.
Croatian: alfa-2-agonistima, benzodiazepinima ili fenotiazinima omogućit će uporabu nižih koncentracija sevoflurana za održavanje anestezije.
English: INDICATION(S) For the induction and maintenance of anaesthesia.
Croatian: INDIKACIJA(E) Za uvođenje u anesteziju i održavanje anestezije.
English: Do not use in animals with a known or suspected genetic susceptibility to malignant hyperthermia.
Croatian: Ne primjenjivati na životinjama za koje se zna ili sumnja da su genetski osjetljivi na malignu hipertermiju.
English: The use of injectable induction agents without premedication has little effect on the concentrations of sevoflurane required for maintenance.
Croatian: Uporaba lijekova koji se ubrizgavaju za uvođenje u anesteziju bez premedikacije gotovo nema učinka na koncentracije sevoflurana potrebne za održavanje anestezije.
English: For the induction and maintenance of anaesthesia.
Croatian: Za uvođenje u anesteziju i održavanje anestezije.
English: The exothermic reaction that occurs between sevoflurane and CO2 absorbents is increased when the CO2 absorbent becomes desiccated (dried out), such as after an extended period of dry gas flow through the CO2 absorbent canisters.
Croatian: Egzotermička reakcija koja nastaje između sevoflurana i apsorbera CO2 povećana je kad se apsorber CO2 osuši, kao što bude nakon produljenog razdoblja protoka suhog plina kroz kanistre apsorbera CO2.
English: Adjustment is, therefore, left to the discretion of the veterinarian.
Croatian: Stoga je odluka određivanja prepuštena veterinarima.
English: Sevoflurane produces unconsciousness by its action on the central nervous system.
Croatian: Sevofluran djeluje na središnji živčani sustav tako da izaziva nesvijest.