FrancophonIA/ELRC3.0 huggingface dataset:
English: Reconstituted and diluted solutions containing visible particles or that are cloudy in appearance should be discarded.
Slovenian: Rekonstituirane in razredčene raztopine, ki vsebujejo vidne delce ali so na videz motne, je treba zavreči.
English: Carcinogenicity studies with eravacycline have not been conducted.
Slovenian: Študij karcinogenosti z eravaciklinom niso izvedli.
English: This medicinal product may pose a risk to the environment (See section 5.3).
Slovenian: To zdravilo lahko predstavlja tveganje za okolje (glejte poglavje 5.3).
English: Xerava must not be mixed with other medicinal products.
Slovenian: Zdravila Xerava ne smemo mešati z drugimi zdravili.
English: The potential influence of severe obesity on eravacycline exposure has not been studied.
Slovenian: Morebitnega vpliva hude debelosti na izpostavljenost eravaciklinu niso proučevali.
English: Long-term use of other similar antibiotic medicines by breast-feeding mothers can stain the child's teeth permanently.
Slovenian: Če doječe matere dolgo časa uporabljajo druga podobna antibiotična zdravila, lahko to trajno obarva otrokove zobe.
English: Pharmacotherapeutic group: Antibacterials for systemic use, tetracyclines, ATC code: J01AA13.
Slovenian: Farmakoterapevtska skupina: sistemski antibiotiki, tetraciklini, oznaka ATC: J01AA13.
English: What Xerava is and what it is used for 2.
Slovenian: Kaj je zdravilo Xerava in za kaj ga uporabljamo 2.
English: a Mean (range) represented b AUC of Day 1 = AUC 0-12 after the first dose and AUC for Day 10 = steady state AUC0- 12
Slovenian: b AUC 1. dne = AUC 0-12 po prvem odmerku in AUC za 10. dan = AUC0-12 v stanju dinamičnega ravnovesja
English: Other medicines and Xerava
Slovenian: Druga zdravila in zdravilo Xerava
English: Each vial is for single use only.
Slovenian: Ena viala je samo za enkratno uporabo.
English: The Cmax and AUC of eravacycline in healthy adults increase approximately in proportion to an increase in dose.
Slovenian: Vrednosti Cmax in AUC eravaciklina pri zdravih odraslih se povečujeta približno sorazmerno s povečevanjem odmerka.
English: MIC Breakpoints (µg/mL) Susceptible (S ≤)
Slovenian: Mejne koncentracije MIC (µg/ml) Občutljiv (S ≤)
English: Your doctor will monitor you closely for any new infections or stop treatment with Xerava and give you another treatment if necessary.
Slovenian: Zdravnik bo skrbno spremljal, ali so se pri vas pojavile kakršne koli nove okužbe, ali pa bo po potrebi prekinil zdravljenje z zdravilom Xerava in vam predpisal novo zdravljenje.
English: The calculated volume of the reconstituted solution should be added to the infusion bag to a target concentration of 0.3 mg/mL, within a range of 0.2 to 0.6 mg/mL.
Slovenian: Izračunano količino rekonstituirane raztopine je treba dodati v infuzijsko vrečo do ciljne koncentracije 0,3 mg/ml, v razponu od 0,2 do 0,6 mg/ml.
English: A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with Xerava should be made, taking into account the benefit of breast-feeding for the child, and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba med nadaljevanjem/prekinitvijo dojenja in nadaljevanjem/prekinitvijo zdravljenja z zdravilom Xerava, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
English: • Abnormal blood test results for liver
Slovenian: • nenormalni rezultati krvnih jetrnih testov.
English: Xerava is not recommended for use during pregnancy as it can:
Slovenian: Zdravila Xerava med nosečnostjo ni priporočljivo uporabljati, saj lahko:
English: Prolonged use may result in the overgrowth of non-susceptible micro-organisms, including fungi.
Slovenian: Podaljšana uporaba lahko povzroči pretirano rast neobčutljivih organizmov, vključno z glivami.
English: In clinical trials, treatment-related diarrhoea occurred in 0.7% of patients; all cases were mild in severity.
Slovenian: V kliničnih preskušanjih se je pri 0,7 % bolnikov pojavila z zdravljenjem povezana driska; vsi primeri so bili blagi.
English: Total Dose (mg)
Slovenian: Celotni odmerek (mg)
English: In case of hypersensitivity reactions, treatment with eravacycline must be discontinued immediately and appropriate emergency measures must be initiated.
Slovenian: Če pride do preobčutljivostnih reakcij, je treba zdravljenje z eravaciklinom takoj prekiniti in uvesti ustrezne nujne ukrepe.
English: Medicines that induce CYP3A4 are expected to increase the rate and extent of metabolism of eravacycline.
Slovenian: Po pričakovanjih naj bi zdravila, ki inducirajo CYP3A4, povečevala hitrost in obseg presnavljanja eravaciklina.
English: There are limited data on the use of eravacycline in pregnant women.
Slovenian: Podatki o uporabi eravaciklina pri nosečnicah so omejeni.
English: Recommended infusion bag size
Slovenian: Priporočena velikost infuzijske vreče
English: It is, therefore, unlikely that you will miss a dose.
Slovenian: Zato je malo verjetno, da odmerka ne bi prejeli.
English: The exact dose needs to be calculated based on the specific patient weight.
Slovenian: Natančen odmerek je treba izračunati na podlagi telesne mase posameznega bolnika.
English: Once the powder has been made into a solution and diluted ready for use, it should be given to you immediately.
Slovenian: Ko se iz praška pripravi raztopina in je ta razredčena tako, da je pripravljena za uporabo, morate raztopino prejeti takoj.
English: Xerava must not be used in children below 8 years of age because it can cause permanent effects on their teeth such as discolouration.
Slovenian: Zdravila Xerava se ne sme uporabljati pri otrocih, mlajših od osem let, ker lahko trajno vpliva na njihove zobe, npr. jih obarva.
English: The mean (%CV) volume of distribution at steady-state in healthy normal volunteers following 1 mg/kg every 12h is approximately 321 L (6.35), which is greater than total body water.
Slovenian: Srednja vrednost (% KV) volumna porazdelitve v stanju dinamičnega ravnovesja pri zdravih običajnih prostovoljcih po odmerku 1 mg/kg vsakih 12 ur znaša približno 321 l (6,35), kar je več od skupne količine vode v telesu.
English: Minimum inhibitory concentration (MIC) breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) for eravacycline are:
Slovenian: Mejne koncentracije minimalne inhibicijske koncentracije (MIC) za eravaciklin, kot jih je določil Evropski odbor za preverjanje protimikrobne občutljivosti (EUCAST), so:
English: See example calculations in Table 3.
Slovenian: Glejte primere izračunov v preglednici 3.
English: Animal studies indicate that eravacycline crosses the placenta and is found in foetal plasma.
Slovenian: Študije na živalih kažejo, da eravaciklin prehaja prek posteljice in ga je mogoče najti v plazmi ploda.
English: Xerava is available in packs containing 1 vial or multipacks comprising 12 cartons, each containing 1 vial.
Slovenian: Zdravilo Xerava je na voljo v pakiranjih, ki vsebujejo 1 vialo, ali skupnih pakiranjih z 12 škatlami, od katerih vsaka vsebuje 1 vialo.
English: Xerava should not be used during pregnancy unless the clinical condition of the woman requires treatment with eravacycline.
Slovenian: Zdravila Xerava se ne sme uporabljati med nosečnostjo, razen če je zdravljenje z eravaciklinom potrebno zaradi kliničnega stanja ženske.
English: Total volume to be diluted (mL)
Slovenian: Celotna količina, ki bo razredčena (ml)
English: How you will be given Xerava 4.
Slovenian: Kako vam bodo dajali zdravilo Xerava 4.
English: CYP3A4 inducers exert their effect in a time-dependent manner, and may take at least 2 weeks to reach maximal effect after introduction.
Slovenian: Učinek induktorjev CYP3A4 je časovno odvisen in po uvedbi lahko traja vsaj dva tedna, da je dosežen največji učinek.
English: What you need to know before you are given Xerava 3.
Slovenian: Kaj morate vedeti, preden boste prejeli zdravilo Xerava 3.
English: Adverse reactions are classified according to MedDRA system organ classification and frequency.
Slovenian: Neželeni učinki so razvrščeni v skladu s klasifikacijo po organskih sistemih in pogostnostjo po MedDRA.
English: Hypersensitivity to the active substance, or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost za učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1.
English: The adverse reactions identified with eravacycline are presented in Table 1.
Slovenian: Neželeni učinki, ki so jih ugotovili pri eravaciklinu, so predstavljeni v preglednici 1.
English: Contents of the pack and other information What Xerava contains
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Xerava
English: Table 2 Mean (%CV) plasma pharmacokinetic parameters of eravacycline after single and multiple intravenous and in healthy adults
Slovenian: Preglednica 2 Srednje vrednosti (% KV) plazemskih farmakokinetičnih parametrov eravaciklina po enkratni in večkratni intravenski infuziji pri zdravih odraslih
English: uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000).
Slovenian: Razredi pogostnosti so izpeljani v skladu z naslednjimi dogovori: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000) in zelo redki (< 1/10.000).
English: The mean pharmacokinetic parameters of eravacycline after single and multiple intravenous infusions (60 minutes) of 1 mg/ kg administered to healthy adults every 12 hours are presented in Table 2.
Slovenian: Srednje vrednosti farmakokinetičnih parametrov eravaciklina po enkratnih in večkratnih intravenskih infuzijah (60 minut) 1 mg/kg, ki so bile dane zdravim odraslim vsakih 12 ur, so predstavljene v preglednici 2.
English: Environmental risk assessment studies have shown that Xerava may pose a risk for the aquatic compartment.
Slovenian: V študijah za oceno tveganja za okolje so dokazali, da zdravilo Xerava lahko predstavlja tveganje za vodni ekosistem.
English: Xerava is indicated for the treatment of complicated intra-abdominal infections (cIAI) in adults (see sections 4.4 and 5.1).
Slovenian: Zdravilo Xerava je indicirano za zdravljenje zapletenih intraabdominalnih okužb (complicated intraabdominal infections - cIAI) pri odraslih (glejte poglavji 4.4 in 5.1).
English: Do not take any medicine to treat your diarrhoea without first checking with your doctor.
Slovenian: Ne jemljite nobenih zdravil za zdravljenje driske, ne da bi se najprej posvetovali z zdravnikom.
English: The C-7 and C-9 substitutions in eravacycline are not present in any naturally occurring or semisynthetic tetracyclines and the substitution pattern imparts microbiological activities including retention of in vitro potency against Gram-positive and Gram-negative strains expressing tetracycline-specific resistance mechanism(s) (i.e., efflux mediated by tet(A), tet(B), and tet(K); ribosomal protection as encoded by tet(M) and tet(Q)).
Slovenian: Substituciji C-7 in C-9 pri eravaciklinu nista prisotni pri nobenih naravnih ali polsintetičnih tetraciklinih, vzorec substitucije pa posreduje mikrobiološke dejavnosti, vključno z ohranjanjem učinka in vitro proti po Gramu pozitivnim in Po Gramu negativnim sevom, ki izražajo mehanizme odpornosti, specifične za tetraciklin (tj. iztok, ki ga posredujejo tet[A], tet[B] in tet[K]; ribosomalna zaščita, kot jo kodirata tet[M] in tet[Q]).
English: Infusion site reactions can be mitigated by reducing the eravacycline infusion concentration or the infusion rate.
Slovenian: Reakcije na mestu infuzije je mogoče ublažiti z zmanjševanjem koncentracije ali hitrosti infuzije eravaciklina.
English: Additional measures to reduce the occurrence and severity of infusion site reactions include decreasing the eravacycline infusion rate and/or concentration.
Slovenian: Dodatni ukrepi za zmanjšanje pojavnosti in resnosti reakcij na mestu infuzije vključujejo zmanjšanje hitrosti in/ali koncentracije infuzije eravaciklina.
English: Keep the vial in the inner carton in order to protect from light.
Slovenian: Vialo shranjujte v notranji škatli za zagotovitev zaščite pred svetlobo.
English: Concomitant use of strong CYP3A4 inducers
Slovenian: Sočasna uporaba močnih induktorjev CYP3A4
English: Eravacycline (and metabolites) is excreted in the milk of lactating rats.
Slovenian: Eravaciklin (in presnovki) se izloča v mleko podgan v obdobju laktacije.
English: The powder for concentrate for solution for infusion (powder for concentrate) will be reconstituted in the vial with 5 mL of water for injections.
Slovenian: Prašek za koncentrat za raztopino za infundiranje (prašek za koncentrat) se rekonstituira v viali s 5 ml vode za injekcije.
English: Other tetracycline antibiotics
Slovenian: Drugi tetraciklinski antibiotiki
English: Therefore, such patients should be monitored for adverse reactions (see Section 4.8), particularly if these patients are obese and/or are also being treated with strong CYP3A inhibitors where the exposure may be further increased (see sections 4.5 and 5.2).
Slovenian: Zato je treba pri takšnih bolnikih spremljati neželene učinke (glejte poglavje 4.8), še posebej, če so ti bolniki debeli in/ali zdravljeni tudi z močnimi zaviralci CYP3A, saj je lahko v tem primeru izpostavljenost dodatno povečana (glejte poglavji 4.5 in 5.2).
English: Do not take any medicine to treat your diarrhoea without first checking with your doctor (see also section 4).
Slovenian: Ne jemljite nobenih zdravil za zdravljenje driske, ne da bi se najprej posvetovali z zdravnikom (glejte poglavje 4).
English: In clinical trials in cIAI, there were no immunocompromised patients, and the majority of patients (80%) had APACHE II scores <10 at baseline; 5.4% of the patients had concurrent bacteraemia at baseline; 34% of the patients had complicated appendicitis.
Slovenian: V kliničnih preskušanjih pri kompliciranih intraabdominalnih okužbah ni bilo imunsko ogroženih bolnikov, pri večini bolnikov (80 %) pa so ocene na lestvici APACHE II ob izhodišču znašale < 10; pri 5,4 % bolnikov je bila v izhodišču prisotna sočasna bakteriemija, pri 34 % bolnikih pa je bil prisoten kompliciran apendicitis.
English: Other bacterial resistance mechanisms that could potentially affect eravacycline are associated with upregulated, non-specific intrinsic multidrug-resistant (MDR) efflux.
Slovenian: Drugi mehanizmi odpornosti bakterij, ki bi lahko morda vplivali na eravaciklin, so povezani z višjo ravnjo nespecifičnega intrinzičnega efluksa, odpornega proti več zdravilom (MDR).
English: Gently invert the bag to mix the solution.
Slovenian: Nežno obračajte vrečo, da zmešate raztopino.
English: The observations included degeneration of the seminiferous tubules, oligospermia, and cellular debris in the epididymides, spermatid retention in the seminiferous tubules, increase of spermatid head retention in Sertoli cells, and vacuolation of Sertoli cells and decreased sperm counts.
Slovenian: Med ugotovitvami so bili degeneracija semenskih cevk, oligospermija in celični drobir v obmodkih, zadrževanje spermatid v semenskih cevkah, povečanje zadrževanja glav spermatid v Sertolijevih celicah ter vakuolacija Sertolijevih celic in zmanjšano število spermijev.
English: Long term use of other tetracyclines during breast-feeding may result in significant absorption by the breast-fed infant and is not recommended because of the risk of dental discolouration and delay in ossification processes of the breast-fed infant.
Slovenian: Zaradi dolgotrajne uporabe drugih tetraciklinov med dojenjem lahko pri dojenem otroku pride do pomembne absorpcije, zato taka uporaba zaradi tveganja obarvanja zob in zakasnitve zakostenevanja pri dojenem otroku, ni priporočljiva.
English: The mechanism of action of eravacycline involves the disruption of bacterial protein synthesis by binding to the 30S ribosomal subunit thus preventing the incorporation of amino acid residues into elongating peptide chains.
Slovenian: Mehanizem delovanja eravaciklina vključuje prekinitev sinteze bakterijskih beljakovin, tako da se eravaciklin veže na ribosomalno podenoto 30S in s tem prepreči vgradnjo aminokislinskih ostankov v podaljšujoče se peptidne verige.
English: Important: Please refer to the Summary of Product Characteristics (SmPC) before prescribing.
Slovenian: Pomembno: Pred predpisovanjem preberite povzetek glavnih značilnosti zdravila.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with Xerava in one or more subsets of the paediatric population in cIAI (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Xerava za eno ali več podskupin pediatrične populacije pri zdravljenju kompliciranih intraabdominalnih okužb (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: Tell your doctor or nurse if you notice any of the following at the site of infusion during or after your treatment: redness of the skin, rash, inflammation, or pain or tenderness.
Slovenian: Obvestite zdravnika ali medicinsko sestro, če na mestu infuzije med zdravljenjem ali po njem opazite kar koli od naslednjega: pordečitev kože, izpuščaj, vnetje, bolečina ali občutljivost.
English: The area under the plasma concentration-time curve (AUC) divided by the minimum inhibitory concentration (MIC) of eravacycline has been shown to be the best predictor of efficacy in vitro, utilising human steady state exposures in a chemostat and confirmed in vivo in animal models of infection.
Slovenian: Območje pod časovno krivuljo plazemske koncentracije (AUC), deljeno z minimalno inhibicijsko koncentracijo (MIC) eravaciklina, je dokazano najboljši kazalnik učinkovitosti in vitro, pri čemer so uporabljene izpostavljenosti v stanju dinamičnega ravnovesja pri človeku v kemostatu, učinkovitost pa je bila potrjena in vivo na živalskih modelih okužbe.
English: Eravacycline is administered via intravenous infusion, using an infusion time of approximately 1 hour to minimise the risk of infusion-site reactions.
Slovenian: Eravaciklin se daje v obliki intravenske infuzije, ki traja približno eno uro, da je tveganje reakcij na mestu infuzije čim manjše.
English: Eravacycline is excreted in both urine and faeces.
Slovenian: Eravaciklin se izloča v urinu in blatu.
English: From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbial contamination, the product should be used immediately.
Slovenian: Z mikrobiološkega stališča je treba zdravilo porabiti takoj, razen če je način odpiranja/rekonstitucije/redčenja tak, da je tveganje mikrobne kontaminacije preprečeno.
English: In studies administering up to 3 mg/kg eravacycline to healthy volunteers it has been observed that doses higher than the recommended dose lead to a higher rate of nausea and vomiting.
Slovenian: V študijah, v katerih so zdravim prostovoljcem dajali do 3 mg/kg eravaciklina, so ugotovili, da se pri odmerkih, višjih od priporočenih, pogosteje pojavita navzea in bruhanje.
English: PK parameters arithmetic mean (%CV)
Slovenian: Farmakokinetični parametri aritmetična sredina (%KV)
English: It is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to treatment with eravacycline (see section 4.8).
Slovenian: To diagnozo je pomembno upoštevati pri bolnikih, pri katerih se med zdravljenjem z eravaciklinom ali po njem pojavi driska (glejte poglavje 4.8).
English: Symptoms to look out for include rash, swelling of the face, feeling lightheaded or faint, tightness of the chest, breathing difficulties, fast heartbeat, or losing consciousness (see also section 4).
Slovenian: Simptomi, na katere morate biti pozorni, so izpuščaj, otekanje obraza, omotica ali omedlevica, stiskanje v prsih, težave z dihanjem, hiter srčni utrip ali izguba zavesti (glejte tudi poglavje 4).
English: Reconstituted Xerava should be a clear, pale yellow to orange solution.
Slovenian: Rekonstituirano zdravilo Xerava mora biti bistra raztopina svetlo rumene do oranžne barve.
English: If you are given more Xerava than you should
Slovenian: Če ste prejeli večji odmerek zdravila Xerava, kot bi smeli
English: Xerava will be given to you in hospital by a doctor or nurse.
Slovenian: Zdravilo Xerava vam bo v bolnišnici dal zdravnik ali medicinska sestra.
English: Xerava is administered only by intravenous infusion over approximately 1 hour (see section 4.4).
Slovenian: Zdravilo Xerava se daje samo z intravensko infuzijo, ki traja približno eno uro (glejte poglavje 4.4).
English: Table 1 Tabulated list of adverse reactions to eravacycline in clinical trials
Slovenian: Preglednica 1 Preglednica z neželenimi učinki eravaciklina v kliničnih preskušanjih
English: Pack sizes: 1 vial and multipacks containing 12 (12 packs of 1) vials.
Slovenian: Velikosti pakiranja: 1 viala in skupna pakiranja, ki vsebujejo 12 vial (12 pakiranj s po 1 vialo).
English: TP-6208 and TP-498 are not considered to be pharmacologically active.
Slovenian: Velja, da TP-6208 in TP-498 nista farmakološko dejavna.
English: The dose should be calculated based on the patient's weight; 1 mg/kg body weight.
Slovenian: Odmerek je treba izračunati glede na telesno maso bolnika (1 mg/kg telesne mase).
English: • Inflammation and pain caused by blood clots at the injection site (thrombophlebitis)
Slovenian: • vnetje in bolečina, ki jo povzročajo krvni strdki na mestu vboda (tromboflebitis);
English: See example calculations in Table 1.
Slovenian: Glejte primere izračunov v preglednici 1.
English: • Inflammation of the pancreas which causes severe pain in the abdomen or back (pancreatitis)
Slovenian: • vnetje trebušne slinavke, ki povzroča hude bolečine v trebuhu ali hrbtu (pankreatitis);
English: Doses more than 2- or 4-fold higher than the clinical exposure (based on AUC) were associated with maternal toxicity (clinical observations and reduced body weight gain and food consumption), and reduced foetal body weights and delays in skeletal ossification in both species and abortion in the rabbit.
Slovenian: Odmerki, ki so bili za več kot dva- ali štirikrat večji od klinične izpostavljenosti (na podlagi AUC), so bili povezani s toksičnostjo pri materi (klinične ugotovitve ter zmanjšana telesna masa in uživanje hrane), z zmanjšanimi telesnimi masami plodov in zakasnitvami okostenitve skeleta pri obeh vrstah ter splavi pri kuncih.
English: Eravacycline is also not affected by aminoglycoside inactivating or modifying enzymes.
Slovenian: Na eravaciklin prav tako ne vplivajo encimi, ki deaktivirajo ali spreminjajo aminoglikozide.
English: Xerava is an antibiotic medicine that contains the active substance eravacycline.
Slovenian: Zdravilo Xerava je zdravilo z antibiotičnim delovanjem in vsebuje učinkovino eravaciklin.
English: In such circumstances, the discontinuation of eravacycline and the use of supportive measures together with the administration of specific treatment for Clostridium difficile should be considered.
Slovenian: V takih primerih je treba razmisliti o prekinitvi zdravljenja z eravaciklinom in uporabi podpornih ukrepov, skupaj z uporabo specifičnega zdravljenja za bakterijo
English: If pancreatitis is suspected, eravacycline should be discontinued.
Slovenian: Če obstaja sum na pankreatitis, je treba dajanje eravaciklina prekiniti.
English: Severe pain in the abdomen and back with fever may be signs of inflammation of the pancreas.
Slovenian: Huda bolečina v trebuhu in hrbtu s povišano telesno temperaturo je lahko znak vnetja trebušne slinavke.
English: Within the range of eravacycline multiple intravenous doses studied clinically, the pharmacokinetic parameters AUC and Cmax demonstrate linearity, but with increasing doses the increase in both AUC and Cmax are slightly less than dose-proportional.
Slovenian: V okviru klinično proučenih več intravenskih odmerkov eravaciklina se pri farmakokinetičnih parametrih AUC in Cmax kaže linearnost, s povečevanjem odmerkov pa je povečanje AUC in Cmax nekoliko manjše od sorazmernega z odmerkom.
English: If you miss a dose of Xerava
Slovenian: Če niste prejeli odmerka zdravila Xerava
English: Xerava will be given to you by a doctor or nurse.
Slovenian: Zdravilo Xerava vam bo dal zdravnik ali medicinska sestra.