FrancophonIA/ELRC3.0 huggingface dataset:
English: In E. coli, a significant part of the strains show high MIC values (minimum inhibitory concentrations) against the lincomycin-spectinomycin combination and may be clinically resistant, although no breakpoint is defined.
Croatian: U znatnom broju sojeva E. coli utvrđene su visoke vrijednosti MIK-a (minimalnih inhibitornih koncentracija) pri primjeni kombinacije linkomicina i spektinomicina.
English: Pigs, poultry
Croatian: Svinje, pilići
English: Powder to be administered with the feed
Croatian: Prašak koji se primjenjuje s hranom za životinje
English: The use of premixes for medicated feeding stuff or powders to be administered with the feed containing a combination of lincomycin and spectinomycin is currently recommended at relatively low doses and for prolonged periods, which infers use for growth promotion.
Croatian: Primjena premiksa za hranu za životinje s dodatkom lijekova ili praškova za primjenu s hranom za životinje koji sadrže kombinaciju linkomicina i spektinomicina trenutačno se preporučuje u razmjerno malim dozama i tijekom duljih razdoblja, što podrazumijeva primjenu za poticanje rasta.
English: Lincomycin-spectinomycin VMD Pulvis
Croatian: Lincomycinspectinomycin VMD Pulvis
English: Pigs, hens pigeons, ducks, turkeys
Croatian: Svinje, kokoši golubovi, patke, purani
English: In chickens, powders for use in drinking water containing a combination of lincomycin and spectinomycin at a dose of 16.65 mg lincomycin and 33.35 mg spectinomycin/kg bw (50 mg combined actives/kg bw) per day for 7 days is considered effective in cases of CRD caused by M. gallisepticum and E. coli, and associated with a low mortality rate.
Croatian: U pilića se primjena praškova u vodi za piće koji sadrže kombinaciju linkomicina i spektinomicina u dozi od 16,65 mg linkomicina i 33,35 mg spektinomicina/kg tjelesne težine (50 mg kombiniranih djelatnih tvari/kg tjelesne težine) na dan tijekom 7 dana smatra učinkovitom u slučajevima kronične respiratorne bolesti uzrokovane bakterijama M. gallisepticum i E. coli te je povezana s niskom stopom smrtnosti.
English: D-30625 Hannover Germany
Croatian: Kon-Pharma GmbH Senator-Bauer-Str. 34 D-30625 Hannover Germany
English: Zone D'Activites Du Bois De Teillay 35150 Janze France
Croatian: Zone D'Activites Du Bois De Teillay
English: Concerning powders for use in drinking water containing a combination of lincomycin and spectinomycin to be administered orally to pigs at a dose of 3.33 mg lincomycin and 6.67 mg spectinomycin/kg bw (10 mg combined actives/kg bw) per day for 7 days is considered effective in cases of porcine proliferative enteropathy caused by L. intracellularis, and possible associated pathogens among which is E. coli.
Croatian: Primjena praškova u vodi za piće koji sadrže kombinaciju linkomicina i spektinomicina za peroralnu primjenu u svinja u dozi od 3,33 mg linkomicina i 6,67 mg spektinomicina/kg tjelesne težine (10 mg kombiniranih djelatnih tvari/kg tjelesne težine) na dan tijekom 7 dana smatra se učinkovitom u slučajevima svinjske proliferativne enteropatije uzrokovane bakterijom L. intracellularis i mogućim povezanim patogenima, među kojima je E. coli.
English: Ramsgate Road Sandwich, Kent CT13 9NJ
Croatian: CT13 9NJ
English: 200 Avenue de Mayenne Zone Industrielle des Touches 53000 Laval France
Croatian: 200 Avenue de Mayenne
English: In Campylobacter, variable but possibly high resistance rates were shown against lincomycin; however the situation could be more complex because those bacteria are also considered susceptible to spectinomycin, for which few data are available.
Croatian: Međutim, problem bi mogao biti složeniji jer se te bakterije također smatraju osjetljivima na spektinomicin za koji je dostupno malo podataka.
English: Pigs, chickens (broilers)
Croatian: Svinje, pilići (tovni)
English: Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis, it has bacteriostatic activity and is active against Mycoplasma spp.
Croatian: Spektinomicin je aminociklitolni antibiotik koji se dobiva iz bakterije Streptomyces spectabilis.
English: Pigs, poultry (broiler, pullet) and turkey
Croatian: Svinje, perad (tovna, mlade kokoši) i purani
English: 2 under Article 35 of Directive 2001/82/EC for veterinary medicinal products containing tylosin to be administered orally via feed or the drinking water to pigs, the CVMP recommended the indication ‘swine dysentery caused by B. hyodysenteriae' to be deleted from the http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/referrals/Veterinary_medicinal_products_cont aining_tylosin_to_be_administered_orally_via_feed_or_the_drinking_water_to_pigs/vet_referral_000098.jsp&mid=WC0b01 ac05805c5170
Croatian: 2http://www.ema.europa.eu/em a/index.jsp?curl=pages/medicines/veterinary/referrals/Veterinary_medicinal_products_containing_tylosin_to_be_administe red_orally_via_feed_or_the_drinking_water_to_pigs/vet_referral_000098.jsp&mid=WC0b01ac05805c5170
English: Delete, where applicable, any references to any poultry species other than chickens.
Croatian: Potrebno je izbrisati sva upućivanja na sve vrste peradi osim pilića kada je to primjenjivo.
English: Linco-Spectin 44 Premix Lincomycin and Spectinomycin
Croatian: Linco-Spectin 44 Premix Linkomicin i spektinomicin
English: Most available clinical efficacy data relate to administration of the combination as powder for use in drinking water; those from the basis for the harmonised dosing regimen of 3.33 mg lincomycin and 6.67 mg spectinomycin/kg bw/day for 7 days for Linco-Spectin 100, as approved during the Article 34 referral procedure (EMEA/V/A/088).
Croatian: Na osnovi tih podataka utvrđen je usklađeni režim doziranja za VMP Linco-Spectin 100 prema kojem se daje doza od 3,33 mg linkomicina i 6,67 mg spektinomicina/kg tjelesne težine/dan tijekom 7 dana kako je odobreno u okviru postupka upućivanja sukladno članku 34. (EMEA/V/A/088).
English: Floridsdorfer Hauptstrasse 1 1210 Wien Austria
Croatian: Zoetis Österreich GmbH Floridsdorfer Hauptstrasse 1
English: Linko-spectin 44 premix Lincomycin and Spectinomycin
Croatian: Linko-spectin 44 premix Linkomicin i spektinomicin
English: In E. coli the MIC distribution appears to be bimodal, with a significant number of strains showing high MIC values; this could partly correspond to natural (intrinsic) resistance.
Croatian: Čini se da je raspodjela MIK-a za E. coli bimodalna, pri čemu znatan broj sojeva pokazuje visoke vrijednosti MIK-a.
English: When considering lincomycin in vitro susceptibility data against B. hyodysenteriae, even if differences occur between geographical areas, and variability arises from the absence of standardised testing methodology, it appears clearly that the minimum inhibitory concentration (MIC) range is broad and http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/referrals/LincoSpectin_100_and_associated_names/vet_referral_000097.jsp&mid=WC0b01ac05805c5170
Croatian: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/referrals/LincoSpectin_100_and_associated_names/vet_referral_000097.jsp&mid=WC0b01ac05805c5170
English: 16,65 g/100 g
Croatian: 16,65 g/100 g 33,35 g/100 g
English: Piglets, calves, chickens
Croatian: Prasad, telad, pilići
English: Calves, piglets, chickens
Croatian: Telad, prasad, pilići
English: Pigs, chickens, turkeys
Croatian: Svinje, pilići, purani
English: Lincospectin 44 mg/g
Croatian: Lincospectin 44 mg/g Linkomicin i spektinomicin
English: Schellingstrasse 1
Croatian: Ramsgate Road
English: PYANOSID, geriamieji milteliai g/146,36 g g/146,36 g
Croatian: 66,7 g/146,36 g
English: Dublin 1
Croatian: 1210 Wien
English: and against some gram-negative bacteria such as E. coli.
Croatian: Djeluje bakteriostatski i djelotvoran je protiv bakterije Mycoplasma spp i nekih gram-negativnih bakterija kao što je E. coli.
English: End of February
Croatian: Kraj veljače
English: # median (min-max)
Croatian: # medijan (min-maks)
English: However, the clinical relevance of these findings is unknown.
Croatian: Međutim, klinička važnost tih nalaza nije poznata.
English: Macrophages are considered the main target organ.
Croatian: Makrofazi se smatraju glavnim ciljnim organom.
English: PAI-2 is known to be uniquely up-regulated in the placenta.
Croatian: Poznato je da se PAI-2 regulira naviše (up-regulation) samo u placenti.
English: As you will be given this medicine by a doctor or a nurse it is unlikely that a dose will be missed.
Croatian: Budući da će Vam ovaj lijek davati liječnik ili medicinska sestra, nije vjerojatno da će doza biti propuštena.
English: • if you are undergoing surgery
Croatian: • ako ćete se podvrgnuti kirurškom zahvatu
English: Safety information in children are available from the prevention study conducted solely in children.
Croatian: Podaci o sigurnosti u djece dostupni su iz ispitivanja prevencije provedenog samo u djece.
English: • if you are taking medicine that increases the risk of bleeding
Croatian: • ako uzimate lijekove koji povećavaju rizik od krvarenja
English: Contents of the pack and other information.
Croatian: Sadržaj pakiranja i druge informacije
English: Data derived from an independent US registry have shown a beneficial effect of Defitelio in routine clinical practice.
Croatian: Podaci dobiveni iz nezavisnog registra Sjedinjenih Država pokazali su koristan učinak lijeka Defitelio u rutinskoj kliničkoj praksi.
English: This is called an ‘intravenous infusion' or drip.
Croatian: To se naziva intravenska infuzija ili drip.
English: Date of latest renewal: 26 July 2018
Croatian: Datum posljednje obnove odobrenja: 26. srpnja 2018
English: • if you have heavy bleeding and need a blood transfusion
Croatian: • ako imate teško krvarenje i potrebna Vam je transfuzija krvi
English: Updated analysis from CIBMTR to be submitted by end of December 2020.
Croatian: CIBMTR-a treba biti dostavljena do kraja prosinca
English: You must not be given a double dose to make up for a missed dose.
Croatian: Ne smije Vam se primijeniti dvostruka doza kako bi se nadoknadila zaboravljena doza.
English: However, the exact mechanism of action of defibrotide is not fully elucidated.
Croatian: Međutim, točan mehanizam djelovanja defibrotida nije u potpunosti razjašnjen.
English: • severe allergic reaction (you might experience swelling of the hands, face, lips, tongue or throat,
Croatian: • teška alergijska reakcija (možete osjetiti oticanje šaka, lica, usana, jezika ili grla, teškoće pri disanju).
English: Side effects in children (1 month to 18 years old) are expected to be similar in type, severity and frequency and no other special precautions are needed.
Croatian: Očekuje se da će nuspojave u djece (od 1 mjeseca do 18 godina) biti sličnog tipa, težine i učestalosti i nikakve druge posebne mjere opreza nisu potrebne.
English: 22079 Italy
Croatian: 22079 Italija
English: You will receive this treatment four times a day for at least 21 days or until your symptoms resolve.
Croatian: Lijek ćete primati četiri puta na dan tijekom najmanje 21 dana ili dok ne dođe do povlačenja simptoma.
English: • if you have problems with blood circulation because your body cannot maintain a constant blood pressure.
Croatian: • ako imate tegoba s cirkulacijom jer Vaš organizam ne može održavati stabilni krvni tlak.
English: In the treatment studies over 50% of the patients were children.
Croatian: U ispitivanjima liječenja, više od 50% bolesnika bila su djeca.
English: • if you are allergic to defibrotide or any of the other ingredients of this medicine (listed in section 6)
Croatian: • ako ste alergični na defibrotid ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
English: However there was no difference in incidence of serious bleeding or bleeding events with fatal outcome.
Croatian: Međutim, nije bilo razlike u incidenciji ozbiljnog krvarenja ili krvarenja sa smrtnim ishodom.
English: The mechanism of action is multifactorial.
Croatian: Mehanizam djelovanja je višestruk.
English: Due to this maternal toxicity, no conclusion can be drawn regarding the effects of defibrotide on embryo-foetal development.
Croatian: Zbog te maternalne toksičnosti ne može se donijeti zaključak o učincima defibrotida na embriofetalni razvoj.
English: No special precautions are indicated.
Croatian: Nisu indicirane posebne mjere opreza.
English: It will be slowly injected (over a 2-hour period) into one of your veins.
Croatian: Lijek ćete primati polako (u trajanju od 2 sata) u jednu od vena.
English: There is limited efficacy and safety data on doses above this level and consequently it is not recommended to increase the dose above 25 mg/kg/day.
Croatian: O djelotvornosti i sigurnosti doza iznad te granice postoje ograničeni podaci, i stoga se ne preporučuje povećavati dozu iznad 25 mg/kg na dan.
English: Considering the nature of the medicinal product, a risk to the newborns/infants is not expected.
Croatian: S obzirom na karakteristike lijeka, ne očekuje se rizik za novorođenčad/dojenčad.
English: The recommended dose in children from one month to 18 years of age is the same as in adults.
Croatian: Preporučena doza za djecu od 1 mjeseca do 18 godina jednaka je kao u odraslih.
English: What Defitelio is and what it is used for
Croatian: Što je Defitelio i za što se koristi
English: Measure 1
Croatian: Mjera br. 1
English: In patients who have or develop clinically significant acute bleeding requiring blood transfusion, Defitelio is not recommended or should be discontinued.
Croatian: U bolesnika koji imaju ili razviju klinički značajno akutno krvarenje koje zahtijeva transfuziju krvi, Defitelio se ne preporučuje ili ga treba ukinuti.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/13/878/001
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/13/878/001
English: Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000).
Croatian: Učestalosti su definirane kao: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000).
English: − If you have any further questions, ask your doctor.
Croatian: Ako imate dodatnih pitanja, obratite se liječniku.
English: The report will also reflect on the safety data being collected during prophylactic treatment, and any potential safety differences related to the difference in indication (ie treatment vs prophylactic therapy).
Croatian: Izvješće će također odražavati podatke o sigurnosti koji se prikupljaju tijekom profilaktičke terapije, kao i sve potencijalne razlike u sigurnosti s obzirom na razliku u indikaciji (tj. liječenje naspram profilaktičke terapije).
English: 4.5 Interaction with other medicinal products and other forms of interaction Potential interactions with recombinant t-PA
Croatian: 4.5 Interakcije s drugim lijekovima i drugi oblici interakcija Potencijalne interakcije s rekombinantnim t-PA
English: *=Kaplan Meier estimates for time-to-event analysis by Day100
Croatian: *=Kaplan Meierove procjene za analizu vremena do razvoja događaja do dana +100
English: • if you are using other medicines to break down blood clots such as tissue plasminogen activator
Croatian: • ako uzimate druge lijekove za razgradnju krvnih ugrušaka kao što je tkivni aktivator plazminogena.
English: These data are from an open label registry and the subjects were not randomised.
Croatian: To su podaci iz otvorenog registra i ispitanici nisu bili randomizirani.
English: Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity or carcinogenicity.
Croatian: Neklinički podaci ne ukazuju na poseban rizik za ljude na temelju konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti ili kancerogenosti.
English: Measure 2 In order to provide comparative data on efficacy, the MAH will submit
Croatian: Mjera br. 2 U svrhu dostavljanja usporednih podataka o djelotvornosti, nositelj odobrenja će predati
English: Consideration should be given to discontinuation of Defitelio during use of such therapy.
Croatian: Treba razmotriti obustavu primjene lijeka Defitelio za vrijeme takve terapije.
English: If particles are observed and/or the liquid in the vial is not clear, the vial must not be used.
Croatian: Ako se opaze čestice i/ili tekućina u bočici nije bistra, bočica se ne smije upotrijebiti.
English: Table 1: Treatment Study Results: Complete Response and Survival Rate of Severe VOD at Day+100
Croatian: Tablica 1: Rezultati ispitivanja liječenja: potpuni odgovor i stopa preživljenja kod teške veno-okluzivne bolesti na dan+100
English: Median length of therapy in those treated with Defitelio was 22 days.
Croatian: Medijan trajanja liječenja u bolesnika liječenih lijekom Defitelio bio je 22 dana.
English: Summary of the Safety Profile
Croatian: Sažetak profila sigurnosti
English: OTHER 200 mg/2.5 mL Gentium Srl
Croatian: DRUGO 200 mg/2.5 mL Gentium Srl
English: If you are sexually active and you or your partner could become pregnant, you both must use effective contraception during treatment with Defitelio and for 1 week after stopping the treatment.
Croatian: Ako ste spolno aktivni i postoji mogućnost trudnoće, Vaše ili Vaše partnerice, oboje morate upotrebljavati učinkovitu kontracepciju tijekom liječenja lijekom Defitelio i još 1 tjedan nakon prestanka liječenja.
English: This can be caused by medicines that are given prior to a stem cell transplantation.
Croatian: Do toga može doći zbog lijekova koji se uzimaju prije transplantacije matičnih stanica.
English: Pharmacotherapeutic group: other antithrombotic agents; ATC code: B01AX01.
Croatian: Farmakoterapijska skupina: drugi antitrombotski lijekovi; ATK oznaka: B01AX01
English: Historical Control
Croatian: Povijesna kontrolna skupina
English: There is no specific antidote for overdose and treatment should be symptomatic.
Croatian: U slučaju predoziranja nema posebnog antidota i liječenje treba biti simptomatsko.
English: Other medicines and Defitelio
Croatian: Drugi lijekovi i Defitelio
English: Talk to your doctor before using Defitelio:
Croatian: Obratite se svom liječniku prije nego primijenite Defitelio:
English: • coagulopathy (disturbance of blood clotting)
Croatian: • koagulopatija (poremećaj zgrušavanja krvi)
English: Defitelio should always be diluted prior to use.
Croatian: Defitelio se mora uvijek razrijediti prije primjene.
English: Marketing Authorisation Holder and Manufacturer Gentium Srl
Croatian: Nositelj odobrenja za stavljanje lijeka u promet i proizvođač Gentium Srl
English: What you need to know before you take Defitelio
Croatian: Što morate znati prije nego počnete primjenjivati Defitelio
English: It is administered by intravenous infusion, over two hours.
Croatian: Primjenjuje se intravenskom infuzijom tijekom dva sata.
English: Temporary discontinuation of Defitelio is recommended in patients who undergo surgery or invasive procedures at significant risk of major bleeding.
Croatian: Privremena obustava lijeka Defitelio preporučuje se u bolesnika podvrgnutih kirurškom zahvatu ili invazivnim postupcima sa značajnim rizikom od velikog krvarenja.
English: At an interim analysis of the on-going registry, data from 96 patients with severe VOD were available.
Croatian: Prilikom međuanalize aktivnog registra bili su dostupni podaci za 96 bolesnika s teškom veno-okluzivnom bolešću.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would not normally be expected to exceed 24 hours at 2-8°C.
Croatian: Ako se ne upotrijebi odmah, vrijeme čuvanja lijeka u primjeni i uvjeti prije primjene odgovornost su korisnika i ne očekuje se da će u normalnim okolnostima prelaziti 24 sata pri temperaturi od 2 do 8°C.
English: Defitelio is for single use only.
Croatian: Defitelio je samo za jednokratnu upotrebu.
English: In each of the clinical trials performed in the treatment of VOD, over 50% of patients were under the age of 18 years.
Croatian: U svakom od kliničkih ispitivanja provedenih u svrhu liječenja veno-okluzivne bolesti, više od 50% bolesnika bilo je mlađe od 18 godina.
English: Use of medicinal products that increase the risk of haemorrhage within 24 hours of Defitelio administration (within 12 hours in the case of unfractionated heparin) is not recommended.
Croatian: Ne preporučuje se upotreba lijekova koji povećavaju rizik od hemoragije unutar 24 sata od primjene lijeka Defitelio (unutar 12 sati u slučaju nefrakcioniranog heparina).
English: Preparation of Defitelio (use aseptic technique):
Croatian: Priprema lijeka Defitelio (primjena aseptičkog postupka):
English: Additional information is shown in the following Table 2.
Croatian: Dodatni podaci prikazani su u nastavku u tablici 2.
English: The treatment should be administered for a minimum of 21 days and continued until the symptoms and signs of severe VOD resolve.
Croatian: Liječenje treba primjenjivati najmanje 21 dan i nastaviti sve dok se simptomi i znakovi teške venookluzivne bolesti jetre ne povuku.
English: The frequency nature and severity of adverse reactions in children are otherwise the same as in adults.
Croatian: Učestalost, narav i težina nuspojava u djece inače su jednake onima u odraslih.
English: Depending on the type and amount of diluent the colour of the diluted solution may vary from colourless to light yellow.
Croatian: Ovisno o tipu i količini otopine za razrjeđivanje boja razrijeđene otopine može varirati od bezbojne do svijetložute.
English: Almost all renal excretion occurs within the first 4 hours.
Croatian: Gotovo potpuno izlučivanje putem bubrega odvija se u prva 4 sata.
English: In both species, the main findings were accumulation of vacuolated macrophages in liver of dogs and in liver, kidneys and lymph nodes of rats.
Croatian: U obje vrste, glavni nalazi bili su akumulacija vakuoliziranih makrofaga u jetri psa te u jetri, bubrezima i limfnim čvorovima štakora.
English: Therefore, the use of defibrotide with antithrombotic/fibrinolytic medicinal products is not recommended.
Croatian: Stoga se ne preporučuje primjena defibrotida s antitrombotskim/fibrinolitičkim lijekovima.
English: Do not use Defitelio if you are pregnant unless your disease requires treatment with Defitelio.
Croatian: Nemojte primjenjivati Defitelio ako ste trudni osim ako Vaša bolest zahtijeva liječenje lijekom Defitelio.
English: The treatment with Defitelio can be initiated and continuously supervised only by an experienced doctor in a hospital or in a specialised centre for stem cells transplantation.
Croatian: Liječenje primjenom lijeka Defitelio smije započeti i neprekidno ga mora nadzirati samo liječnik s iskustvom, u bolnici ili u specijaliziranom centru za transplantaciju matičnih stanica.
English: The Day+100 all-cause mortality in patients with severe VOD who were not treated with defibrotide was 69%, and 61% in those patients who received defibrotide.
Croatian: Smrtnost zbog svih uzroka na dan+100 u bolesnika s teškom veno-okluzivnom bolešću koji nisu bili liječeni defibrotidom iznosila je 69%, a u bolesnika koji su primali defibrotid 61%.
English: However, if used, in exceptional cases, caution should be exercised by closely monitoring the coagulation parameters (see section 4.4).
Croatian: Međutim, ako se ova kombinacija primijeni u iznimnim okolnostima, potreban je oprez uz pomno praćenje parametara koagulacije (vidjeti dio 4.4).
English: Juvenile toxicity
Croatian: Toksičnost u mladunčadi
English: Potential interactions with antithrombotic fibrinolytic agents Defibrotide has a profibrinolytic effect (see section 5.1) and this may potentially enhance the activity of antithrombotic/fibrinolytic medicinal products.
Croatian: Potencijalne interakcije s antitrombotskim fibrinolitičkim lijekovima Defibrotid ima profibrinolitički učinak (vidjeti dio 5.1) i to potencijalno može povećati aktivnost antitrombotskih/fibrinolitičkih lijekova.
English: It is recommended that the diluted Defitelio solution be administered to patients using an infusion set equipped with a 0.2 μm in-line filter.
Croatian: Preporučuje se da se razrijeđena otopina lijeka Defitelio primijeni bolesnicima s pomoću kompleta za infuziju opremljenog linijskim filtrom od 0,2 μm.