FrancophonIA/ELRC3.0 huggingface dataset:
English: Warnings and precautions Test and checks
Croatian: Upozorenja i mjere opreza
English: - Inflammation or ulceration of the mouth
Croatian: - Upala ili nastajanje ranica usne šupljine
English: One of the mechanisms by which hydroxycarbamide acts is the elevation of HbF concentrations in Sickle Cell Disease patients.
Croatian: Jedan od mehanizama djelovanja hidroksikarbamida je povećanje koncentracije HbF u bolesnika s bolešću srpastih stanica.
English: Recently, hydroxycarbamide has shown to be associated with the generation of nitric oxide suggesting that nitric oxide stimulates cyclic guanosine monophosphatase (cGMP) production, which then activates a protein kinase and increases the production of HbF.
Croatian: Nedavno je primijećeno da je hidroksikarbamid povezan s nastankom dušikova oksida, što ukazuje na to da dušikov oksid stimulira stvaranje cikličke gvanozin monofosfataze (cGMP) koja zatim aktivira protein-kinazu i potiče stvaranje HbF.
English: Acute mucocutaneous toxicity has been reported in patients receiving hydroxycarbamide at a dosage several times greater than that recommended.
Croatian: Akutna mukokutana toksičnost zabilježena je u bolesnika koji primaju hidroksikarbamid u dozama nekoliko puta većima od preporučene doze.
English: After 18 months of treatment, there was a significant difference in the number of vaso-occlusive crises between the hydroxycarbamide group and placebo group, mean difference
Croatian: Nakon 18 mjeseci liječenja zabilježena je značajna razlika u broju vazookluzivnih kriza između skupine koja je primala hidroksikarbamid i skupine koja je primala placebo, srednja vrijednost razlike
English: If neutropenia or thrombocytopenia occurs, hydroxycarbamide dosing should be temporarily withheld and full blood cell count with white cell differential should be monitored weekly.
Croatian: Ako se pojavi neutropenija ili trombocitopenija, doziranje hidroksikarbamida treba privremeno prekinuti te jednom tjedno napraviti kompletnu krvnu sliku s diferencijalnom bijelom krvnom slikom.
English: The digital distribution of these vasculitic ulcerations and progressive clinical behaviour of peripheral vasculitic insufficiency leading to digital infarct or gangrene were distinctly different than the typical skin ulcers generally described with Hydroxycarbamide.
Croatian: Distribucija tih vaskulitičnih ulceracija na prstima ruku i nogu te progresivno kliničko ponašanje periferne vaskulitične insuficijencije koje je dovelo do nekroze prstiju ili gangrene bili su izrazito različiti od tipičnih kožnih ulkusa koji su uglavnom opisani pri primjeni hidroksikarbamida.
English: Table 4: Comparison of the Number of Clinical Events before and after Intervention in the Hydroxycarbamide and Placebo Groups
Croatian: Tablica 4.: Usporedba broja kliničkih događaja prije i nakon intervencije u skupini koja je primala hidroksikarbamid i skupini koja je primala placebo Hidroksikarbamid
English: Impaired fertility has been observed in male rats (see section 5.3).
Croatian: Poremećaj plodnosti primijećen je u mužjaka štakora (vidjeti dio 5.3.).
English: Hydroxycarbamide may cause hepatotoxicity and liver function tests should be monitored during treatment.
Croatian: Hidroksikarbamid može uzrokovati hepatotoksičnost te je tijekom liječenja potrebno provoditi pretrage funkcije jetre.
English: Full blood cell count with white cell differential and reticulocyte count should be monitored every 2 weeks for the first 2 months following treatment initiation.
Croatian: Potrebno je napraviti kompletnu krvnu sliku s diferencijalnom bijelom krvnom slikom i brojem retikulocita svaka dva tjedna tijekom prva dva mjeseca nakon početka liječenja.
English: Due to potentially severe clinical outcomes for the cutaneous vasculitic ulcers reported in patients with myeloproliferative disease, hydroxycarbamide should be discontinued if cutaneous vasculitic ulcerations develop.
Croatian: Zbog potencijalno teških kliničkih ishoda kožnih vaskulitičnih ulkusa prijavljenih u bolesnika s mijeloproliferativnim bolestima, liječenje hidroksikarbamidom treba prekinuti ako se razviju kožne vaskulitične ulceracije.
English: HbF interferes with the polymerisation of HbS (sickle haemoglobin) and thus impedes the sickling of red blood cell.
Croatian: HbF interferira s polimerizacijom HbS (hemoglobin S) i na taj način sprečava deformacije eritrocita.
English: The MSH study showed increased haematological toxicity resulting in a dose reduction in the hydroxycarbamide group as compared with placebo, but there were no infections related to neutropenia or bleeding episodes due to thrombocytopenia.
Croatian: MSH ispitivanje pokazalo je povećanu hematološku toksičnost koja je rezultirala smanjenjem doze u skupini koja je primala hidroksikarbamid u odnosu na placebo, ali nije bilo infekcija povezanih s neutropenijom ili epizoda krvarenja zbog trombocitopenije.
English: At concentrations ranging from 10 to 300 µM, hydroxycarbamide does not stimulate the in vitro ATPase activity of recombinant human P glycoprotein (P-gp), indicating that hydroxycarbamide is not a P-gp substrate.
Croatian: In vitro u koncentracijama u rasponu od 10 do 300 μM, hidroksikarbamid ne stimulira aktivnost ATPaze rekombinantnog humanog P-glikoproteina (P-gp), što ukazuje na to da hidroksikarbamid nije supstrat
English: Preclinical toxicity studies have demonstrated the most commonly observed effects include bone marrow depression in rats, dogs and monkeys.
Croatian: Neklinička ispitivanja toksičnosti pokazala su da je najčešće uočen učinak depresija koštane srži u štakora, pasa i majmuna.
English: Take as directed by your doctor using the dosing syringes provided.
Croatian: Uzimajte prema uputi liječnika i upotrijebite priložene štrcaljke za doziranje.
English: Hydroxycarbamide administered to male rats at 60 mg/kg body weight/day (about double the recommended usual maximum dose in humans) produced testicular atrophy, decreased spermatogenesis and significantly reduced their ability to impregnate females.
Croatian: Hidroksikarbamid koji se davao mužjacima štakora u dozi od 60 mg/kg tjelesne težine na dan (oko dvostruko više od preporučene maksimalne doze za ljude) izazvao je atrofiju testisa, smanjenje spermatogeneze i značajno smanjenje njihove sposobnosti da oplode ženke.
English: - to check your blood count before and during treatment with Xromi - to monitor your liver before and during treatment with Xromi - to monitor your kidneys before and during treatment with Xromi
Croatian: - kako bi pratio stanje vaše jetre prije i tijekom liječenja lijekom Xromi - kako bi pratio stanje vaših bubrega prije i tijekom liječenja lijekom Xromi
English: Bone-marrow suppression is the major toxic effect of hydroxycarbamide and is dose related.
Croatian: Supresija koštane srži predstavlja jak toksični učinak hidroksikarbamida koji je povezan s dozom.
English: This medicinal product contains methyl parahydroxybenzoate (E218) which may cause allergic reactions (possibly delayed).
Croatian: Ovaj lijek sadrži metilparahidroksibenzoat (E218) koji može uzrokovati alergijske reakcije (moguće i odgođene reakcije).
English: Multi-centre study of hydroxycarbamide in Sickle Cell Anaemia (MSH) The MSH study was a multicentre, randomised, and double-blind study, which compared hydroxycarbamide with placebo in adults with Sickle Cell Anaemia (HbSS genotype only) with the objective of reducing the frequency of pain crises.
Croatian: Multicentrično ispitivanje hidroksikarbamida kod anemije srpastih stanica (MSH) MSH ispitivanje bilo je multicentrično, randomizirano i dvostruko slijepo ispitivanje u kojem je hidroksikarbamid uspoređen s placebom u odraslih osoba s anemijom srpastih stanica (samo genotip HbSS) s ciljem smanjenja učestalosti bolnih kriza.
English: Sickle Cell disease is an inherited blood disorder that affects the disc shaped red cells of the blood.
Croatian: Bolest srpastih stanica nasljedni je poremećaj krvi koji pogađa crvene krvne stanice u obliku diska.
English: Generally, the patient's antibody response to vaccines may be decreased.
Croatian: Općenito, reakcija protutijela bolesnika na cjepivo može biti umanjena.
English: Subjects assigned to standard treatment (n = 61) continued to receive monthly blood transfusions to maintain 30% HbS or lower, while those assigned to the alternative treatment (n = 60), after having received blood transfusions for a mean duration of 4.5 years (±2.8), started oral hydroxycarbamide at 20 mg/kg/day, which was escalated to each participant's maximum tolerated dose.
Croatian: Ispitanici podvrgnuti standardnom liječenju (n = 61) nastavili su primati mjesečne transfuzije krvi kako bi se HbS održao na razini od 30 % ili nižoj, dok se u ispitanika koji su primali zamjensko liječenje (n = 60) nakon liječenja transfuzijama krvi u prosječnom trajanju od 4,5 godina (± 2,8) započelo s peroralnom primjenom hidroksikarbamida u dozi od 20 mg/kg/dan, koja je za svakog sudionika povećana do najviše podnošljive doze.
English: Hydroxycarbamide was started at low dose (15 mg/kg per day) and increased at 12- weekly intervals by 5 mg/kg per day until mild bone marrow depression was achieved, as judged by either neutropenia or thrombocytopenia.
Croatian: Liječenje je započelo s niskom dozom hidroksikarbamida (15 mg/kg na dan) koja se povećavala u intervalima od 12 tjedana za 5 mg/kg na dan do postizanja blage depresije koštane srži, što se ocjenjivalo na temelju neutropenije ili trombocitopenije.
English: Concurrent use of hydroxycarbamide and other myelosuppressive medicinal products or radiation therapy may increase bone marrow depression, gastro-intestinal disturbances or mucositis.
Croatian: Istodobna primjena hidroksikarbamida i drugih mijelosupresivnih lijekova ili terapije zračenjem može povećati stupanj depresije koštane srži, pogoršati gastrointestinalne poremećaje ili mukozitis.
English: If you get any of the following side effects, talk to your doctor or go to hospital immediately:
Croatian: Ako primijetite bilo koju od sljedećih nuspojava, odmah se obratite liječniku ili otiđite u bolnicu.
English: Do not take Xromi if you are planning to have a baby without first speaking to your doctor for advice.
Croatian: Ako planirate imati dijete, nemojte uzimati Xromi bez savjetovanja sa svojim liječnikom.
English: Patients on hydroxycarbamide wishing to conceive should stop treatment 3 to 6 months before pregnancy if possible.
Croatian: Bolesnici i bolesnice koji uzimaju hidroksikarbamid, a žele začeti dijete, terapiju moraju prekinuti tri do šest mjeseci prije trudnoće ako je to moguće.
English: An erythema caused by radiation therapy may be aggravated by hydroxycarbamide.
Croatian: Eritem izazvan terapijom zračenjem može se pogoršati zbog djelovanja hidroksikarbamida.
English: The study also showed a statistically significant increase in HbF and Hb levels and a decrease in haemolytic markers in the groups treated with hydroxycarbamide.
Croatian: Ispitivanje je također pokazalo statistički značajno povećanje u razinama HbF i Hb te smanjenje markera hemolize u skupini liječenoj hidroksikarbamidom.
English: Blood parameters for renal and hepatic impairment should be closely monitored, and hydroxycarbamide should be discontinued if necessary.
Croatian: Potrebno je pomno praćenje krvnih parametara radi utvrđivanja oštećenja bubrega i jetre, a liječenje hidroksikarbamidom treba prekinuti ako je to potrebno.
English: This syringe should be recommended for doses less than or equal to 3 ml (each graduation of 0.1 ml contains 10 mg of hydroxycarbamide).
Croatian: Ovu štrcaljku treba preporučiti za doze koje su manje ili jednake količini od 3 ml (svaka gradacija od 0,1 ml sadrži 10 mg hidroksikarbamida).
English: In patients with Sickle Cell Disease, neutropenia was reported in isolated cases of hydroxycarbamide overdose (1.43 times and 8.57 times of the maximum recommended dose of 35 mg/kg body weight/ day).
Croatian: U bolesnika s bolešću srpastih stanica neutropenija je zabilježena u izoliranim slučajevima predoziranja hidroksikarbamidom (1,43 puta i 8,57 puta više od maksimalne preporučene doze od
English: There are no data that support specific dose adjustments in patients with hepatic impairment.
Croatian: Nema podataka koji podupiru posebne prilagodbe doza u bolesnika s oštećenjem funkcije jetre.
English: The anaemia commonly observed has mainly been due to an infection with Parvovirus or a splenic sequestration.
Croatian: Često uočena anemija uglavnom je bila posljedica infekcije parvovirusom ili sekvestracije u slezeni.
English: Patients with normal (CrCl> 90 ml/min), mild (CrCl 60-89 ml/min), moderate (CrCl 3059 ml/min), severe (CrCl 15-29 ml/min) renal impairment, and End Stage Renal Disease (CrCL < 15 ml/min) received hydroxycarbamide as a single dose of 15 mg/kg body weight.
Croatian: Bolesnici s normalnom funkcijom bubrega (CrCl > 90 ml/min), blagim (CrCl 60 - 89 ml/min), umjerenim (CrCl 30 - 59 ml/min) ili teškim oštećenjem funkcije bubrega (CrCl 15 - 29 ml/min), te bolesnici u završnom stadiju bolesti bubrega (CrCl < 15 ml/min)
English: Patients must not be treated with hydroxycarbamide and anti-retroviral medicinal products concurrently (see sections 4.3 and 4.4).
Croatian: Bolesnici se ne smiju istodobno liječiti hidroksikarbamidom i antiretrovirusnim lijekovima (vidjeti dijelove 4.3. i 4.4.).
English: The macrocytosis caused by hydroxycarbamide is not vitamin B12 or folic acid dependent.
Croatian: Makrocitoza uzrokovana hidroksikarbamidom ne ovisi o vitaminu B12 ili folnoj kiselini.
English: Fatal hepatic events were reported most often in patients treated with the combination of hydroxycarbamide, didanosine, and stavudine.
Croatian: Hepatički događaji sa smrtnim ishodom najčešće su zabilježeni u bolesnika liječenih kombinacijom hidroksikarbamida, didanozina i stavudina.
English: Hydroxycarbamide is unequivocally genotoxic and although conventional long-term carcinogenicity studies have not been conducted, hydroxycarbamide is presumed to be a transspecies carcinogen which implies a carcinogenic risk to humans.
Croatian: Hidroksikarbamid se nedvojbeno pokazao genotoksičnim i iako nisu provedena konvencionalna dugoročna ispitivanja kancerogenosti, smatra se da je hidroksikarbamid kancerogen za različite vrste,
English: Other known pharmacological effects of hydroxycarbamide which may contribute to its beneficial effects in Sickle Cell Disease include decrease of neutrophils, improved deformability of sickled cells, and altered adhesion of red blood cells to the endothelium.
Croatian: Ostali poznati farmakološki učinci hidroksikarbamida koji mogu pridonijeti njegovim pozitivnim učincima kod bolesti srpastih stanica uključuju smanjenje broja neutrofila, povećanje mogućnosti deformacije srpastih stanica i promjenu adhezije eritrocita na endotel.
English: In an open single-dose study in adult patients with Sickle Cell Disease the influence of renal function on pharmacokinetics of hydroxycarbamide was assessed.
Croatian: U otvorenom ispitivanju jednokratnog doziranja na odraslim bolesnicima s bolešću srpastih stanica ocijenjen je utjecaj funkcije bubrega na farmakokinetiku hidroksikarbamida.
English: Toxicology studies have also demonstrated testicular atrophy with decreased spermatogenesis and sperm count in rats and decreased testis weight and reduced sperm counts in mice as well.
Croatian: Toksikološka ispitivanja također su pokazala atrofiju testisa sa smanjenjem spermatogeneze i broja spermija u štakora te smanjenje težine testisa i broja spermija u miševa, dok je u pasa zabilježen reverzibilan zastoj spermatogeneze.
English: Turn the bottle back the right way up and carefully remove the syringe from the adaptor, holding it by the barrel rather than the plunger.
Croatian: 6. Okrenite bočicu u pravilan uspravni položaj i pažljivo izvucite štrcaljku iz nastavka, držeći štrcaljku za tijelo, a ne za klip.
English: Wipe up spillages immediately.
Croatian: Proliveni lijek odmah obrišite.
English: This syringe should be recommended for doses greater than 3 ml (each graduation of 0.25 ml contains 25 mg of hydroxycarbamide).
Croatian: Ovu štrcaljku treba preporučiti za doze koje su veće od 3 ml (svaka gradacija od 0,25 ml sadrži 25 mg hidroksikarbamida).
English: Xromi is a clear, colourless to pale yellow, oral solution.
Croatian: Xromi je bistra, bezbojna do blijedožuta oralna otopina.
English: In patients receiving long-term therapy with hydroxycarbamide for myeloproliferative disorders, such as polycythemia, secondary leukaemia has been reported.
Croatian: U bolesnika koji primaju dugotrajnu terapiju hidroksikarbamidom radi mijeloproliferativnih poremećaja, kao što je policitemija, prijavljen je razvoj sekundarne leukemije.
English: Teratogenic effects manifested as partially ossified cranial bones, absence of eye sockets, hydrocephaly, bipartite sternebrae, and missing lumbar vertebrae.
Croatian: Uočeni teratogeni učinci uključivali su djelomično okoštavanje kostiju lubanje, odsustvo očnih duplji, hidrocefaliju, dvodijelne sternebre i nepostojeće slabinske kralješke.
English: Bioavailability is complete or nearly complete in cancer patients.
Croatian: U bolesnika s rakom bioraspoloživost je potpuna ili gotovo potpuna.
English: Hydroxycarbamide was administered at an initial dose of 20 mg/kg/day.
Croatian: Hidroksikarbamid je primijenjen u početnoj dozi od 20 mg/kg/dan.
English: Final model-based TCD velocities were 143 cm/s (95% CI 140-146) in children who received standard transfusions and 138 cm/s (95% CI 135-142) in those who received hydroxycarbamide, with a difference of 4.54 cm/s (95% CI 0.10-8.98).
Croatian: Konačne brzine strujanja krvi utvrđene TCD pretragom i utemeljene na modelima bile su 143 cm/s (95 % CI 140 - 146) u djece koja su primila standardne transfuzije i 138 cm/s (95 % CI 135 - 142) u djece koja su primila hidroksikarbamid, s razlikom od 4,54 cm/s (95 % CI 0,10 - 8,98).
English: 3 ml and 12 ml dosing syringes.
Croatian: Štrcaljke za doziranje od 3 ml i 12 ml.
English: After oral administration hydroxycarbamide is readily absorbed from the gastrointestinal tract.
Croatian: Nakon peroralne primjene hidroksikarbamid se brzo apsorbira iz gastrointestinalnog sustava.
English: Xromi contains hydroxycarbamide, a substance which reduces the growth and multiplication of some cells in the bone marrow.
Croatian: Xromi sadrži hidroksikarbamid, tvar koja smanjuje rast i umnožavanje nekih stanica u koštanoj srži.
English: Iron overload improved more in the hydroxycarbamide than the transfusion arm, with a greater average change in serum ferritin (-1805 versus -38 ng/mL; p < 0.0001) and liver iron concentration (average = -1.9 mg/g versus +2.4 mg/g dry weight liver; p = 0.0011).
Croatian: Preopterećenje željezom u većoj se mjeri poboljšalo u skupini koja je primala hidroksikarbamid nego u skupini koja je primala transfuzije, s većom prosječnom promjenom u koncentraciji feritina u serumu (-1805 naspram -38 ng/ml; p < 0,0001) i u koncentraciji željeza u jetri (prosjek = -1,9 mg/g naspram +2,4 mg/g suhe težine u jetri; p = 0,0011).
English: Concomitant anti-retroviral medicinal products for HIV disease (see sections 4.4 and 4.5)
Croatian: Istodobna primjena antiretrovirusnih lijekova za liječenje HIV-a (vidjeti dijelove 4.4. i 4.5.).
English: The MAH shall ensure that in each Member State where Xromi is marketed, all healthcare professionals and patients/carers who are expected to prescribe and use Xromi have access to/are provided with the following educational package to be disseminated through professional bodies:
Croatian: Xromi u prometu svi zdravstveni radnici i bolesnici/njegovatelji od kojih se očekuje propisivanje i uporaba lijeka Xromi imaju pristup/dobiju materijale za obuku u nastavku koje treba distribuirati putem stručnih tijela:
English: Wigston, Leicester LE18 4YL
Croatian: Nova Laboratories Limited Martin House Gloucester Crescent Wigston, Leicester LE18 4YL
English: Xanthan gum (E415) Sucralose (E955)
Croatian: Ksantanska guma (E415) Sukraloza (E955) Aroma jagode
English: PHARMACEUTICAL FORM AND CONTENTS Oral solution.
Croatian: OBLIK I SADRŽAJ Oralna otopina.
English: Hydroxycarbamide has minor influence on the ability to drive and use machines.
Croatian: Hidroksikarbamid malo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Cross-over comparison with placebo (Ferster et al 1996) A randomized cross-over study was conducted in 25 children and young adults (age range: 2 to 22 years) with homozygous sickle cell anaemia and severe clinical manifestations (defined as >3 vasoocclusive crises in the year before study entry and/or with previous history of stroke, acute chest syndrome, recurrent crises without a free interval, or splenic sequestration).
Croatian: Provedeno je randomizirano unakrsno ispitivanje u 25-ero djece i mladih odraslih osoba (u dobi od 2 do 22 godine) s homozigotnom anemijom srpastih stanica i teškim kliničkim manifestacijama (definirane kao > 3 vazookluzivne krize u godini prije ulaska u ispitivanje ili s anamnezom moždanog udara, akutnog sindroma prsnog koša, rekurentnih kriza bez slobodnog intervala, ili sekvestracije u slezeni).
English: Uncommon: may affect up to 1 in 100 people - Any yellowing of the whites of the eyes or skin (jaundice)
Croatian: Manje česte nuspojave: mogu se javiti u do 1 na 100 osoba - Bilo kakvo žutilo bjeloočnica ili kože (žutica)
English: Hydroxycarbamide is unequivocally genotoxic in a wide range of test systems.
Croatian: Hidroksikarbamid se u mnogim sustavima za ispitivanje nedvojbeno pokazao genotoksičnim.
English: The patient's antibody response to vaccines may be decreased.
Croatian: Reakcija protutijela bolesnika na cjepivo može biti umanjena.
English: stavudine, and indinavir (a drop in your white cell count may occur) - live vaccines, e.g. measles, mumps, rubella (MMR), chicken pox
Croatian: stavudin i indinavir (može se javiti pad broja bijelih krvnih stanica) - živa cjepiva, npr. za ospice, zaušnjake, rubeolu, vodene kozice
English: Hydroxycarbamide crosses the placental barrier, demonstrated by dams exposed to hydroxycarbamide during gestation.
Croatian: Hidroksikarbamid prolazi kroz placentu, što je dokazano na ženkama izloženima hidroksikarbamidu tijekom gravidnosti.
English: The full blood cell count with white cell differential, reticulate count, and platelet count should be monitored regularly (see section 4.2).
Croatian: Potrebno je redovito raditi kompletnu krvnu sliku s diferencijalnom bijelom krvnom slikom, brojem retikulocita i brojem trombocita (vidjeti dio 4.2.).
English: The usual starting dose of hydroxycarbamide is 15 mg/kg/day and usual maintenance dose is between 20-25 mg/kg.
Croatian: Uobičajena početna doza hidroksikarbamida je 15 mg/kg/dan, a uobičajena doza održavanja je od 20
English: - if you have a liver disease (additional monitoring may be needed) - if you have a kidney disease (the dose may be adjusted) - if you have leg ulcers - if you have a known lack of vitamin B12 or folate
Croatian: - ako imate bolest bubrega (može biti potrebna prilagodba doze) - ako imate ulkuse nogu
English: Observations in monkeys have also shown lymphoid atrophy and degeneration of the small and large intestine.
Croatian: U promatranjima na majmunima također su zabilježene atrofija limfoidnog tkiva i degenerativne promjene tankog i debelog crijeva.
English: Parents and care givers should avoid hydroxycarbamide contact with skin or mucous membrane.
Croatian: Roditelji i njegovatelji trebaju izbjegavati kontakt hidroksikarbamida s kožom ili sluznicom.
English: Pharmacotherapeutic group: Antineoplastic agents, other antineoplastic agents, ATC code: L01XX05.
Croatian: 5.1 Farmakodinamička svojstva Farmakoterapijska skupina: Antineoplastični lijekovi, ostali antineoplastični lijekovi, ATK oznaka:
English: The other ingredients are xanthan gum, sucralose (E955), strawberry flavour, methyl parahydroxybenzoate (E218), sodium hydroxide, and purified water.
Croatian: Ostali su sastojci ksantanska guma, sukraloza (E955), aroma jagode, metilparahidroksibenzoat
English: Leg ulcers are a common complication of Sickle Cell Disease, but have also been reported in patients treated with hydroxycarbamide.
Croatian: Ulkusi nogu česta su komplikacija kod bolesti srpastih stanica, ali zabilježeni su i u bolesnika liječenih hidroksikarbamidom.