FrancophonIA/ELRC3.0 huggingface dataset:
English: No antibodies to antithrombin alfa have been detected up to 90 days following treatment with ATryn.
Estonian: ATryn-ravile järgneva päeva jooksul ei tuvastatud antikehade esinemist alfa-antitrombiini vastu.
English: • dizziness
Estonian: • iiveldus.
English: Loading dose (IU) = [(100 - patient's pre-treatment AT activity level in %) /2.28] x Body Weight in kg
Estonian: Boolusannus (RÜ) = [(100 - patsiendi ravieelne AT aktiivsus %-ides) /2,28] x kehakaal kg-des
English: Nausea
Estonian: Kuumatunne
English: Due date reaction or lack of efficacy.
Estonian: • Ravimi kõrvaltoimed, sh ebaefektiivsus
English: General disorders and administration site conditions
Estonian: Üldised häired ja manustamiskoha reaktsioonid Sage
English: Other medicines and ATryn
Estonian: Eriline ettevaatus on vajalik ravimiga ATryn
English: It is normally given in association with heparin or low molecular weight
Estonian: Seda manustatakse tavaliselt koos hepariini või
English: Thus, concurrent administration of antithrombin with heparin, low molecular weight heparin, or other anticoagulants that potentiate the anticoagulant activity of antithrombin to a patient with increased risk of bleeding must be monitored clinically and biologically.
Estonian: Seetõttu on oluline kliiniliselt ja bioloogiliselt jälgida verejooksu riskiga patsiente, kellele üheaegselt manustatakse antitrombiini ja hepariini, madalmolekulaarset hepariini või teisi antitrombiini antikoagulantset aktiivsust potentseerivaid
English: The reconstituted solution should be used immediately and no longer than 3 hours after reconstitution.
Estonian: Manustamiskõlblikuks muudetud lahus tuleb kasutada kohe ja mitte hiljem kui 3 tundi pärast
English: Gastrointestinal disorders
Estonian: • infusioonikoha sügelus
English: The doctor will treat you, as appropriate, if you have any particular side effects.
Estonian: Kui teil esinevad teatud kõrvaltoimed, ravib arst teid vastavalt nendele.
English: Venipuncture site haemorrhage
Estonian: Veenipunktsiooni koha hemorraagia
English: Contents of the pack and other information
Estonian: A. PAKENDI MÄRGISTUS JA INFOLEHT
English: In studies with ATryn the following side effects were reported: Common side effects (may affect up to 1 in 10 people) are:
Estonian: Sage (võivad esineda kuni 1 patsiendil 10st):
English: Vascular disorders
Estonian: Kõrvaltoimete tabel
English: Common
Estonian: Prantsusmaa
English: Frequent antithrombin activity assessments and dosing adjustments may be necessary when starting treatment and just
Estonian: Ravi alguses ja kohe pärast kirurgilisi operatsioone võib olla vajalik sage antitrombiini aktiivsuse määramine.
English: This initial loading dose is based on body weight and on the pretreatment antithrombin activity level.
Estonian: Boolusannuse arvutamisel arvestatakse patsiendi kehakaalu ja ravieelset antitrombiini aktiivsust.
English: • nausea
Estonian: • kuumatunne
English: The risk of diminution of antithrombin levels by prolonged treatment with a non-fractionated heparin should be
Estonian: Pikaajalise ravi korral fraktsioneerimata hepariiniga tuleb arvestada ka antitrombiini väärtuste vähenemise võimalusega.
English: Feeling hot
Estonian: Viaali etikett
English: If your child:
Estonian: Kui teie laps:
English: • one in the morning
Estonian: • üks hommikul
English: 2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Estonian: 2 KVALITATIIVNE JA KVANTITATIIVNE KOOSTIS
English: 10 DATE OF REVISION OF THE TEXT
Estonian: 10 TEKSTI LÄBIVAATAMISE KUUPÄEV
English: Pregnancy Not relevant.
Estonian: Rasedus Ei ole asjakohane.
English: Before opening: 3 years.
Estonian: Enne avamist: 3 aastat.
English: Date of first authorisation: 23 April 2014 Date of latest renewal:
Estonian: Müügiloa esmase väljastamise kuupäev: 23. aprill 2014 Müügiloa viimase uuendamise kuupäev:
English: These signs may be:
Estonian: Sümptomid võivad olla:
English: Then, your doctor will regularly examine your child during treatment.
Estonian: Seejärel kontrollib teie arst teie last ravi jooksul regulaarselt.
English: 11.4% of patients needed to be re-treated after treatment discontinuation.
Estonian: 11,4% patsientidest vajasid ravi katkestamise järel kordusravi.
English: Continue the treatment at the usual frequency: one dose in the morning and one in the late afternoon.
Estonian: Jätkake ravi tavapärase sagedusega: üks annus hommikul ja üks õhtul.
English: • Purified water
Estonian: • Puhastatud vesi
English: Automatism and conduction disorders are expected because of the suppression of sympathetic compensative mechanisms.
Estonian: Eeldatakse automatismi ja juhtehäireid sümpaatilise kompensatsioonimehhanismide allasurumise tõttu.
English: Therefore the need for treatment should be carefully weighed up.
Estonian: Seega tuleb ravi hoolikalt kaaluda.
English: The frequency of the following side effects is not known (frequency cannot be estimated from the available data)
Estonian: Järgmiste kõrvaltoimete esinemissagedus on teadmata (esinemissagedust ei saa hinnata olemasolevate andmete alusel)
English: • This medicine has been prescribed for your child only.
Estonian: • Ravim on välja kirjutatud üksnes teie lapsele.
English: Appropriate monitoring of the child is required until symptoms disappear.
Estonian: Last tuleb nõuetekohaselt jälgida kuni sümptomite kadumiseni.
English: When treatment was re-initiated, a satisfactory response was observed in a large majority of patients.
Estonian: Ravi taasalustamisel täheldati rahuldavat ravivastust valdaval enamikul patsientidest.
English: Haemangioma can be superficial or deep.
Estonian: Hemangioom võib olla pinnapealne või sügav.
English: Remove the items from the box
Estonian: Võtke esemed karbist välja
English: After first opening: 2 months.
Estonian: Pärast esmast avamist: 2 kuud.
English: Always give this medicine to your child exactly as your doctor or pharmacist has told you.
Estonian: Andke seda ravimit oma lapsele alati täpselt nii, nagu arst või apteeker on teile soovitanud.
English: It is to be initiated in infants aged 5 weeks to 5 months (see section 4.2).
Estonian: Ravi tuleb alustada imikutel vanuses 5 nädalat kuni 5 kuud (vt lõik 4.2).
English: Combinations should consider the 2 following situations (not mutually exclusive):
Estonian: Ravimite koosmanustamisel tuleb silmas pidada kaht järgmist olukorda (ei välista teineteist):
English: The percentage contributions of these routes to total metabolism are 42%, 41% and 17%, respectively, but with considerable variability between individuals.
Estonian: Need teed moodustavad kogu metabolismist vastavalt 42%, 41% ja 17%, kuid on eri inimestel erinevad.
English: • lack of partial agonist activity (or intrinsic sympathomimetic activity).
Estonian: • osalise agonisti aktiivsuse puudumine (või sisemine sümpatomimeetiline aktiivsus).
English: This is because HEMANGIOL can change the way other medicines work, and some medicines can have an effect on the way HEMANGIOL works.
Estonian: Seda sellepärast, et HEMANGIOL võib mõjutada muude ravimite toimet ja mõned ravimid võivad mõjutada HEMANGIOLi toimet.
English: HEMANGIOL might need to be discontinued at least 48h before the anaesthesia.
Estonian: Võib olla on vajalik katkestada ravi HEMANGIOLiga vähemalt 48 h enne anesteesiat.
English: Your doctor will advise you on whether you need to stop breastfeeding or not.
Estonian: Teie arst annab teile teada, kas peaksite imetamise lõpetama.
English: Other medicines and HEMANGIOL
Estonian: Muud ravimid ja HEMANGIOL
English: Do not mix the medicine with a full bottle of milk or juice.
Estonian: Ärge segage ravimit terve pudeli piima või mahla hulka.
English: Both agents may induce hypotension and/or heart failure in patients whose cardiac function is partially controlled because of additive inotropic effects.
Estonian: Mõlemad ained võivad esile kutsuda hüpotensiooni ja/või südamepuudulikkust patsientidel, kelle südame funktsiooni osaliselt kontrollitakse lisaaine inotroopse mõju tõttu.
English: Breast-feeding Breastfeeding mothers: see section 4.4 and section 4.5.
Estonian: Imetamine Imetavad emad: vt lõik 4.4 ja lõik 4.5.
English: • The medicine is to be given during or straight after a feed.
Estonian: • Ravimit tuleb anda söögi ajal või vahetult pärast seda.
English: 6 Contents of the pack and other information What HEMANGIOL contains
Estonian: 6 Pakendi sisu ja muu teave Mida HEMANGIOL sisaldab
English: No special requirements.
Estonian: Erinõuded hävitamiseks puuduvad.
English: Based on a retrospective study, a minority of patients (12%) required a re-initiation of systemic treatment.
Estonian: Retrospektiivse uuringu alusel vajas süsteemse ravi taasalustamist väike hulk patsiente (12%).
English: Close the bottle.
Estonian: Sulgege pudel
English: Do not use any soap or alcohol based product to clean.
Estonian: Ärge kasutage puhastamiseks seepi või alkoholil põhinevat lahust.
English: Warnings and precautions Before your child receives HEMANGIOL, tell your doctor:
Estonian: Hoiatused ja ettevaatusabinõud Enne, kui teie laps saab HEMANGIOLi, teavitage oma arsti:
English: Open the bottle
Estonian: Avage pudel
English: Although some data were equivocal, based on the overall available in vitro and in vivo data, it can be concluded that propranolol is devoid of genotoxic potential.
Estonian: Kuigi osad andmed olid ebamäärased, võib olemasolevate in vitro ja in vivo andmete põhjal järeldada, et propranolool ei ole genotoksilise potentsiaaliga.
English: Use the mixture within 2 hours of preparation.
Estonian: Kasutage segu 2 tunni jooksul alates valmistamisest.
English: Do not use any other measuring device.
Estonian: Ärge kasutage teisi mõõteseadmeid.
English: • Hemangiol is for oral use.
Estonian: • HEMANGIOL on suukaudseks kasutamiseks.
English: • Second- or third-degree atrioventricular blocks
Estonian: • teise või kolmanda astme atrioventrikulaarne blokaad;
English: • If your child has diabetes: in this case, your child's blood sugar level should be measured more frequently.
Estonian: • kui teie lapsel on diabeet: sellisel juhul tuleb teie lapse vere glükoositaset sagedamini mõõta;
English: • one in late afternoon
Estonian: • üks õhtul
English: The educational materials for caregivers treating children with HEMANGIOL should include the following key safety elements:
Estonian: Õppematerjalid lapsi HEMANGIOLiga ravivatele hooldajatele peavad sisaldama järgmisi olulisi ohutuselemente:
English: It is also aimed to instruct caregivers to correctly feed the children during treatment in order to avoid the risk of hypoglycaemia.
Estonian: Selle eesmärk on ka juhendada hooldajaid lapsi ravi ajal õigesti toitma, et vältida hüpoglükeemia teket.
English: Wipe the outside dry.
Estonian: Pühkige süstal väljast kuivaks.
English: • Tell your doctor before giving this medicine.
Estonian: • Andke enne ravimi manustamist oma arstile teada.
English: The educational pack must be available for distribution prior to the launch of the new indication (treatment of proliferating infantile haemangioma) in the Member State.
Estonian: Õppepakk peab olema levitamiseks saadaval enne uue kasutusnäidustuse (prolifereeruva infantiilse hemangioomi ravi) liikmesriigis turule laskmist.
English: These effects rarely led to definitive treatment discontinuation (see section 4.4).
Estonian: Ravi lõplikku katkestamist põhjustasid need toimed harva (vt lõik 4.4).
English: Concomitant treatment with systemic corticosteroids may increase the risk of hypoglycemia (see section 4.5).
Estonian: Samaaegne ravi süsteemsete kortikosteroididega võib hüpoglükeemia ohtu suurendada (vt lõik 4.5).
English: Clinical monitoring of the child condition, and dose readjustment, need to be performed at least monthly.
Estonian: Lapse seisundi kliinilist jälgimist ja annuste reguleerimist tuleb teha vähemalt iga kuu.
English: Concomitant use may reduce the reflex sympathetic response involved when excessive distal vasodilatation.
Estonian: Samaaegne kasutamine võib vähendada reflektoorset sümpaatilist reaktsiooni, mis kaasneb ülemäärase distaalse vasodilatatsiooniga.
English: Locate this number on the oral syringe.
Estonian: Leidke see arv süstla skaalal.
English: In this case, inform the caregiver, and increase monitoring of blood glucose levels, particularly at the start of treatment.
Estonian: Sel juhul andke sellest hooldajale teada ja tõhustage vere glükoositasemete jälgimist, eriti ravi alguses.
English: The volume of distribution of propranolol is approximately 4 L/kg.
Estonian: Propranolooli jaotusruumala on ligikaudu 4 l/kg.
English: Do not lie the child down immediately after the administration.
Estonian: Ärge pange last vahetult pärast manustamist lamama.
English: 9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Estonian: 9 ESMASE MÜÜGILOA VÄLJASTAMISE/MÜÜGILOA UUENDAMISE KUUPÄEV
English: Do not shake the bottle before use.
Estonian: Ärge loksutage pudelit enne kasutamist.
English: In the minority of patients showing a relapse of symptoms after treatment discontinuation, treatment may be re-initiated under the same conditions with a satisfactory response.
Estonian: Väiksel hulgal patsientidel, kellel ilmneb sümptomite taastumine pärast ravi lõpetamist, võib ravi taasalustada samadel tingimustel rahuldava ravivastusega.
English: If you are breastfeeding your child, and if you are taking medicines that must not be used with HEMANGIOL (see ‘‘If you are breastfeeding your child'' and “Other medicines and HEMANGIOL”) do not give this medicine to your child.
Estonian: Kui imetate last ja võtate ravimeid, mida ei tohi koos HEMANGIOLiga kasutada (vt lõike „Kui imetate oma last” ja „Teised ravimid ja HEMANGIOL”), ärge andke seda ravimit oma lapsele.
English: When a patient is scheduled for surgery, beta-blocker therapy should be discontinued at least 48 hours prior to the procedure.
Estonian: Kui patsiendil on planeeritud operatsioon, tuleb ravi beetablokaatoriga lõpetada vähemalt 48 tundi enne protseduuri.
English: If different people are involved, good communication is essential in order to ensure the safety of the child.
Estonian: Kui lapsega tegelevad eri inimesed, on lapse turvalisuse tagamiseks oluline hea suhtlemine.
English: The bottle should not be shaken before use.
Estonian: Pudelit ei tohi enne kasutamist raputada.
English: The mixing should be used within 2 hours.
Estonian: Segu peab kasutama 2 tunni jooksul.
English: In case of severe and/or symptomatic bradycardia or hypotension occurring at any time during treatment, treatment must be discontinued and a specialist advice should be sought.
Estonian: Tõsise ja/või sümptomaatilise bradükardia või hüpotensiooni korral, mis esineb mis tahes ajal ravi vältel, tuleb ravi lõpetada ja küsida nõu spetsialistilt.
English: HEMANGIOL should be administered for a 6-month period.
Estonian: HEMANGIOLi tuleb manustada 6 kuud.
English: • is allergic to propranolol or any of the other ingredients of this medicine (listed in section 6).
Estonian: • on propranolooli või ravimi mis tahes koostisosa (loetletud lõigus 6) suhtes allergiline.
English: It is sometimes called ‘strawberry mark' because the surface of a haemangioma looks a bit like a strawberry.
Estonian: Seda kutsutakse vahel „maasikajäljeks”, sest hemangioomi pind meenutab maasikat.
English: 1 bottle of 120 mL and 1 oral syringe.
Estonian: 1 pudel 120 ml ja 1 suusüstal.
English: An allergic reaction can include a rash, itching or shortness of breath.
Estonian: Allergiline reaktsioon võib hõlmata löövet, sügelust või õhupuudust;
English: • Bronchospasm may develop particularly in patients with asthma.
Estonian: • tekkida võib bronhospasm, eriti astmaga patsientidel;
English: • Cold extremities,
Estonian: • külmad jäsemed;
English: 4 CLINICAL PARTICULARS 4.1 Therapeutic indications
Estonian: 4 KLIINILISED ANDMED 4.1 Näidustused
English: Very limited safety data of propranolol in PHACE syndrome patients are available.
Estonian: Saadaval on väga vähe ohutusalaseid andmeid propranolooli kasutamise kohta PHACE sündroomiga patsientidel.
English: This educational pack is aimed at increasing awareness about the potential risk of hypotension, bradycardia, and bronchospasm, after taking HEMANGIOL, and providing guidance on how to monitor/manage that risk.
Estonian: Selle õppepaki eesmärk on suurendada teadlikkust hüpotensiooni, bradükardia ja bronhospasmi tekke ohu kohta pärast HEMANGIOLi võtmist ja anda juhiseid selle ohu jälgimise/haldamise kohta.
English: PHACE syndrome
Estonian: PHACE sündroom
English: Patients (71.3% female; 37% aged 35-90 days old and 63% aged 91-150 days old) presented a target haemangioma on the head in 70% and majority of the infantile haemangiomas were localized (89%).
Estonian: Patsientidel (71,3% naissoost; 37% vanuses 35-90 päeva ja 63% vanuses 91-150 päeva) oli sihthemangioom peas 70% juhtudel ja enamik infantiilseid hemangioome lokaliseeriti (89%).
English: Other Central Nervous System disorders were principally observed during the early periods of treatment.
Estonian: Teisi kesknärvisüsteemi häireid kirjeldati peamiselt ravi varastel perioodidel.
English: 4 Possible side effects
Estonian: 4 Võimalikud kõrvaltoimed
English: Pharmacotherapeutic group: Beta-Blocking agent, non-selective, ATC code: C07AA05
Estonian: Farmakoterapeutiline rühm: mitteselektiivsede beetablokaatorid, ATC kood: C07AA05
English: A monitoring of electrolyte should be performed in these patients.
Estonian: Neil patsientidel tuleks jälgida elektrolüütide taset.
English: Approximately 90% of circulating propranolol is bound to plasma proteins (albumin and alpha1 acid glycoprotein).
Estonian: Ligikaudu 90% ringlevast propranoloolist on seotud plasmavalkudega (albumiin ja alfa-1-happe glükoproteiin).
English: If you have given to your child more HEMANGIOL than you should, please consult your doctor immediately.
Estonian: Kui andsite oma lapsele rohkem HEMANGIOLi kui ette nähtud, pidage viivitamatult nõu oma arstiga.
English: What HEMANGIOL looks like and contents of the pack
Estonian: Kuidas HEMANGIOL välja näeb ja pakendi sisu
English: The readministration of propranolol may be considered when the child has fully recovered; in case of reoccurrence, treatment should be permanently discontinued.
Estonian: Propranolooli manustamise jätkamist võib kaaluda, kui laps on täielikult tervenenud; haiguse taastekkel tuleb ravi lõplikult katkestada.
English: Check the HEMANGIOL dose in milligrams (mg) as prescribed by your doctor.
Estonian: Kontrollige HEMANGIOLi annust milligrammides (mg) vastavalt arsti väljakirjutusele.
English: Here is how to open it: push down the plastic cap while turning the cap counter-clockwise (to the left).
Estonian: Selle avamine käib nii: suruge plastkork alla ja pöörake korki vastupäeva (vasakule).
English: The administration of beta2 agonists and inhaled corticosteroids is possible.
Estonian: Võimalik on beeta2-agonistide ja inhaleeritavate kortikosteroidide manustamine.
English: In children with diabetes, blood glucose monitoring should be more frequent and followed by the endocrinologist.
Estonian: Diabeediga laste puhul tuleb vere glükoosisisaldust jälgida sagedamini ja seda peab kontrollima endokrinoloog.
English: The regimen 3 mg/kg/day during 6 months (selected at the end of the phase II part of the study) presented 60.4% of success versus 3.6% in the placebo arm (p value < 0.0001).
Estonian: Ravirežiimi 3 mg/kg/ööpäevas 6 kuu jooksul (valiti uuringu II faasi lõpul) oli õnnestumise määr 60,4%, võrreldes 3,6%-ga platseeborühmas (p-väärtus < 0,0001).
English: • Moreover, if you are breastfeeding your child, it is important to tell your doctor, pharmacist or nurse which medicines you are yourself taking, as they may pass into your breast-milk and interfere with the treatment of your child.
Estonian: • Veelgi enam, kui imetate oma last, tuleb oma arstile, apteekrile või meditsiiniõele öelda, mis ravimit te võtate, sest need võivad sattuda rinnapiima ja mõjutada lapse ravi.
English: Instructions for use: • Step 1.
Estonian: Kasutusjuhend • 1. samm.
English: • Urticaria (allergic reaction of the skin), alopecia (loss of hair),
Estonian: • urtikaaria (naha allergiline reaktsioon), alopeetsia (juustekaotus);
English: Age (35-90 days / 91150 days), gender and haemangioma location (head / body) subgroups did not identify differences in response to propranolol.
Estonian: Vanuse (35-90 päeva / 91150 päeva), soo ja hemangioomi asukoha (pea/keha) järgi moodustatud alamrühmades ei tuvastatud erinevusi propranolooli ravivastuses.
English: Do not use this medicine after the expiry date which is stated on the outer carton and bottle label.
Estonian: Ärge kasutage seda ravimit pärast kõlblikkusaega, mis on märgitud välispakendil ja pudeli sildil.
English: Box of 1 bottle.
Estonian: Karbis on 1 pudel.
English: Improvement of haemangioma was observed at 5 weeks of treatment by propranolol in 88% of patients.
Estonian: Hemangioomi paranemist jälgiti 88% patsientidel propranolooliga ravimise 5. nädalal.
English: The treatment of your child has been initiated by a physician who has expertise in the diagnosis, treatment and management of infantile haemangioma.
Estonian: Teie lapse ravi on alustanud arst, kes on ekspert infantiilse hemangioomi diagnoosimise, ravi ja jälgimise alal.
English: 4- Repeat this cleaning process 3 times.
Estonian: 4- Korrake loputamist 3 korda.
English: Biotransformation and elimination:
Estonian: Biotransformatsioon ja eritumine
English: Propranolol is a beta-blocker that is characterised by three pharmacological properties:
Estonian: Propranolool on beetablokaator, mida iseloomustavad kolm farmakoloogilist omadust:
English: • Agitation, nightmares, irritability,
Estonian: • erutus, õudusunenäod, ärritatavus;
English: The medicine should not be put in the full filled bottle.
Estonian: Ravimit ei tohi lisada kogu pudelisisule.
English: • Information on the conditions for which HEMANGIOL should not be given
Estonian: • teave seisundite kohta, mille puhul HEMANGIOLi anda ei tohi;
English: • the absence of cardioselective beta-1 beta-blocking activity,
Estonian: • kardioselektiivse beeta-1 beetablokeeriva toime puudumine;
English: In dietary administration studies in which mice and rats were treated with propranolol hydrochloride for up to 18 months at doses of up to 150 mg/kg/day, there was no evidence of drug-related tumorigenesis.
Estonian: Toitumisest sõltuva manustamisega uuringutes, kus hiiri ja rotte raviti propranoloolvesinikkloriidiga kuni 18 kuud annustes kuni 150 mg/kg ööpäevas, ei leitud tõendeid ravimiga seotud tumorogeneesi kohta.
English: • Low blood pressure below the following limits:
Estonian: • madal vererõhk, mis jääb allapoole järgmisi piire:
English: 6-12 months
Estonian: 6…12 kuud
English: • Tell your doctor, pharmacist or nurse if you are giving, have recently given or might give any other medicines to your child.
Estonian: • Teatage oma arstile, apteekrile või meditsiiniõele, kui te võtate või olete hiljuti võtnud või kavatsete võtta mis tahes muid ravimeid.
English: • HEMANGIOL and the feed must be given by the same person in order to avoid the risk of hypoglycaemia.
Estonian: • HEMANGIOLi ja sööki peab andma sama inimene, et vältida hüpoglükeemia tekkimise ohtu.
English: Treatment success was defined as a complete or nearly complete resolution of the target haemangioma, which was evaluated by blinded centralized independent assessments made on photographs at Week 24, in the absence of premature treatment discontinuation.
Estonian: Ravi õnnestumiseks oli määratletud sihthemangioomi täielik või peaaegu täielik lahenemine, mida hinnati 24. nädalal fotodel pimemenetlusega, tsentraliseeritult ja sõltumatult, kui ravi enneaegselt ei lõpetatud.
English: After the first intake and each dose increase, a clinical monitoring, including blood pressure and heart rate must be performed at least hourly for at least 2 hours.
Estonian: Pärast esmast ravimi manustamist ja iga annuse suurendamist tuleb patsienti kliiniliselt jälgida, sh vererõhku ja südame löögisagedust mõõta vähemalt kord tunnis vähemalt 2 tunni jooksul.
English: • a reduction of both VEGF and bFGF signalling pathways and subsequent angiogenesis /
Estonian: • nii VEGF-i kui bFGF-i signaaliradade ja edasise angiogeneesi/prolifereerumise vähendamine.