FrancophonIA/ELRC3.0 huggingface dataset:
English: If these medicinal products are to be prescribed with the hydrochlorothiazide-telmisartan combination, monitoring of potassium plasma levels is advised.
Croatian: Ako se moraju propisati ovi lijekovi uz kombinaciju hidroklorotiazid-telmisartan, savjetuje se praćenje vrijednosti kalija u plazmi.
English: • Severe renal impairment (creatinine clearance <30 ml/min).
Croatian: • Teško oštećenje funkcije bubrega (klirens kreatinina <30 ml/min).
English: Based on the experience with the use of other medicinal products that blunt the renin-angiotensin system, concomitant use of the above medicinal products may lead to increases in serum potassium and is, therefore, not recommended (see section
Croatian: Na osnovi iskustva s primjenom drugih lijekova koji oslabljuju sustav renin-angiotenzin, istodobna primjena gore spomenutih lijekova može dovesti do povećanja kalija u serumu, te se stoga ne preporučuje (vidjeti dio 4.4).
English: In addition, there was a significantly higher incidence of hyperkalaemia, renal failure, hypotension and syncope in the combination arm.
Croatian: Nadalje, došlo je do značajno veće incidencije hiperkalemije, zatajenja bubrega, hipotenzije i sinkope u skupini liječenoj kombinacijom.
English: Non-steroidal anti-inflammatory medicinal products NSAIDs (i.e. acetylsalicylic acid at anti-inflammatory dosage regimens, COX-2 inhibitors and nonselective NSAIDs) may reduce the diuretic, natriuretic and antihypertensive effects of thiazide diuretics and the antihypertensive effects of angiotensin II receptor antagonists.
Croatian: NSAIL-i (tj. acetilsalicilatna kiselina u protuupalnim režimima doziranja, COX-2 inhibitori i neselektivni NSAIL-i) mogu reducirati diuretski, natriuretski i antihipertenzivni učinak tiazidskih diuretika te antihipertenzivni učinak antagonista receptora angiotenzina II.
English: Kinzalkomb should be kept in the sealed blister due to the hygroscopic property of the tablets.
Croatian: Kinzalkomb je potrebno čuvati u zatvorenom blisteru zbog higroskopskih svojstava tableta.
English: The use of Kinzalkomb during breast feeding is not recommended.
Croatian: Primjena Kinzalkomba tijekom dojenja se ne preporučuje.
English: The use of Kinzalkomb in children and adolescents up to the age of 18 years is not recommended.
Croatian: Primjena Kinzalkomba kod djece i adolescenata ispod 18 godina starosti se ne preporučuje.
English: Kinzalkomb may be less effective in lowering the blood pressure in black patients.
Croatian: Kinzalkomb može biti manje učinkovit u snižavanju krvnog tlaka kod bolesnika crne rase.
English: You should store your medicine in the original package in order to protect the tablets from moisture.
Croatian: Čuvati u originalnom pakiranju radi zaštite tableta od vlage.
English: In patients whose vascular tone and renal function depend predominantly on the activity of the reninangiotensin-aldosterone system (e.g. patients with severe congestive heart failure or underlying renal disease, including renal artery stenosis), treatment with medicinal products that affect this system has been associated with acute hypotension, hyperazotaemia, oliguria, or rarely acute renal failure (see section 4.8).
Croatian: Kod bolesnika čiji vaskularni tonus i bubrežna funkcija ovise uglavnom o aktivnosti sustava reninangiotenzin-aldosteron (npr. bolesnici s teškim kongestivnim zatajenjem srca ili oni s postojećom bubrežnom bolesti, uključujući stenozu bubrežne arterije), liječenje ostalim lijekovima koji utječu na ovaj sustav povezano je s akutnom hipotenzijom, hiperazotemijom, oligurijom, ili rijetko akutnim zatajenjem bubrega (vidjeti dio 4.8).
English: Due to the hydrochlorothiazide component, markedly low blood pressure and low blood levels of potassium can also happen, which may result in nausea, sleepiness and muscle cramps and/or irregular heartbeat associated with the concomitant use of drugs such as digitalis or certain anti-arrhythmic treatments.
Croatian: Zbog hidroklorotiazida kao komponente, također može doći i do izrazitijeg niskog krvnog tlaka i niskih vrijednosti kalija u krvi, što može rezultirati mučninom, pospanošću i grčevima mišića, i/ili nepravilnim otkucajima srca povezanim s istodobnom primjenom lijekova kao što su digitalis ili određeni antiaritmici.
English: What Kinzalkomb contains
Croatian: Što Kinzalkomb sadrži
English: The observed increased occurrence rate of sepsis associated with the use of telmisartan may be either a chance finding or related to a mechanism not currently known.
Croatian: Primijećena povećana stopa pojavnosti sepse povezana s primjenom telmisartana može biti zbog ili slučajnog otkrića ili nekog mehanizma koji za sada nije poznat.
English: In the "Prevention Regimen For Effectively avoiding Second Strokes" (PRoFESS) trial in patients 50 years and older, who recently experienced stroke, an increased incidence of sepsis was noted for telmisartan compared with placebo, 0.70 % vs. 0.49 % [RR 1.43 (95 % confidence interval 1.002.06)]; the incidence of fatal sepsis cases was increased for patients taking telmisartan (0.33 %) vs. patients taking placebo (0.16 %) [RR 2.07 (95 % confidence interval 1.14 - 3.76)].
Croatian: U ispitivanju „Prevention Regimen For Effectively avoiding Second Strokes” (PRoFESS), provedenom na bolesnicima od 50 i više godina starosti, koji su nedavno imali moždani udar, zabilježena je povećana incidencija sepse uz telmisartan u usporedbi s placebom, 0,70 % u odnosu na 0,49 % [RR 1,43 (95 % interval pouzdanosti 1,00 - 2,06)]; incidencija slučajeva fatalne sepse je povećana za bolesnike koji su uzimali telmisartan (0,33 %) u odnosu na bolesnike na placebu (0,16 %) [RR 2,07 (95 % interval pouzdanosti 1,14 - 3,76)].
English: If you are intolerant to some sugars, consult your doctor before taking Kinzalkomb.
Croatian: Ako ne podnosite neke šećere, posavjetujte se s liječnikom prije početka primjene Kinzalkomba.
English: Thiazides may increase the risk of adverse effects caused by amantadine.
Croatian: Tiazidi mogu povećati rizik od nuspojava koje uzrokuje amantadin.
English: The degree to which hydrochlorothiazide is removed by haemodialysis has not been established.
Croatian: Stupanj do kojeg se hidroklorotiazid uklanja hemodijalizom nije utvrđen.
English: Telmisartan: The pharmacokinetics of orally administered telmisartan are non-linear over doses from 20 - 160 mg with greater than proportional increases of plasma concentrations (Cmax and AUC) with increasing doses.
Croatian: Telmisartan: Farmakokinetika peroralno primijenjenog telmisartana nije linearna u dozama od 20-160 mg s više nego proporcionalnim povećanjem koncetracija u plazmi (Cmax i AUC) pri rastućim dozama.
English: Hepatic function abnormal / liver disorder
Croatian: Abnormalna jetrena funkcija / poremećaj jetre
English: Although hypokalaemia may develop with the use of thiazide diuretics, concurrent therapy with telmisartan may reduce diuretic-induced hypokalaemia.
Croatian: Iako se hipokalemija može razviti s primjenom tiazidskih diuretika, istodobna terapija telmisartanom može reducirati hipokalemiju izazvanu diureticima.
English: Cholestyramine and colestipol resins
Croatian: Kolestiramin i kolestipol smole
English: The elimination half-life is not changed in patients with hepatic impairment.
Croatian: Poluvrijeme eliminacije je nepromijenjeno kod bolesnika s oštećenjem funkcije jetre.
English: In addition, Kinzalkomb should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Croatian: Nadalje, Kinzalkomb se mora primjenjivati se s oprezom kod bolesnika s oštećenom jetrenom funkcijom ili progresivnom bolesti jetre, s obzirom da manje promjene u ravnoteži tekućine i elektrolita mogu precipitirati hepatičku komu.
English: Kinzalkomb may increase the blood pressure lowering effect of other medicines used to treat high blood pressure or of medicines with blood pressure lowering potential (e.g. baclofen, amifostine).
Croatian: Kinzalkomb može pojačati učinak snižavanja krvnog tlaka drugih lijekova koji se primjenjuju u liječenju visokog krvnog tlaka ili lijekova s potencijalom snižavanja krvnog tlaka (npr. baklofenak, amifostin).
English: Based on available data from epidemiological studies, cumulative dose-dependent association between HCTZ and NMSC has been observed.
Croatian: Na temelju dostupnih podataka iz epidemioloških ispitivanja, između HCTZ-a i NMSC-a primijećena je povezanost ovisna o kumulativnoj dozi.
English: Remove your Kinzalkomb tablet from the blister only directly prior to intake.
Croatian: Izvadite Kinzalkomb tabletu iz blistera neposredno prije primjene.
English: Kinzalkomb is a combination of an angiotensin II receptor antagonist, telmisartan, and a thiazide diuretic, hydrochlorothiazide.
Croatian: Kinzalkomb je kombinacija antagonista receptora angiotenzina II, telmisartana i tiazidskog diuretika, hidroklorotiazida.
English: As with other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or obstructive hypertrophic cardiomyopathy.
Croatian: Kao i uz druge vazodilatatore, potreban je poseban oprez kod bolesnika koji pate od aortalne i mitralne stenoze, ili opstruktivne hipertrofične kardiomiopatije.
English: Telmisartan: Following oral administration peak concentrations of telmisartan are reached in 0.5 - 1.5 h after dosing.
Croatian: Telmisartan: nakon peroralne primjene vršne koncentracije telmisartana postižu se 0,5-1,5 h nakon doziranja.
English: Upper respiratory tract infection, urinary tract infection including cystitis
Croatian: Infekcije gornjeg dišnog sustava, infekcije mokraćnog sustava uključujući cistitis
English: Based on modest experience in patients with mild to moderate renal impairment (creatinine clearance of 30 - 60 ml/min, mean about 50 ml/min) no dosage adjustment is necessary in patients with decreased renal function.
Croatian: Na osnovi skromnog iskustva kod bolesnika s blagim do umjerenim oštećenjem funkcije bubrega (klirens kreatinina od 30-60 ml/min, prosjek oko 50 ml/min), nije potrebno prilagođavanje doze kod bolesnika sa smanjenom bubrežnom funkcijom.
English: Telmisartan is not removed from blood by haemodialysis.
Croatian: Telmisartan se ne uklanja iz krvi hemodijalizom.
English: pentamidine, sparfloxacine, terfenadine, vincamine IV.)
Croatian: sparfloksacin, terfenadin, vinkamin i.v.)
English: Precautions to be taken before handling or administering the medicinal product Kinzalkomb should be kept in the sealed blister due to the hygroscopic property of the tablets.
Croatian: Mjere opreza koje je potrebno poduzeti prije rukovanja ili primjene lijeka Kinzalkomb se mora čuvati u zatvorenom blisteru zbog higroskopnih svojstava tableta.
English: Unless continued angiotensin II receptor antagonist therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Croatian: Osim ako se nastavak terapije antagonistom receptora angiotenzina II smatra neophodnim, bolesnice koje planiraju trudnoću moraju prijeći na zamjensko antihipertenzivno liječenje koje ima utemeljen profil sigurnosti za primjenu u trudnoći.
English: There is no experience regarding the administration of Kinzalkomb in patients with recent kidney transplantation.
Croatian: Ne postoji iskustvo glede primjene Kinzalkomba kod bolesnika s nedavno presađenim bubregom.
English: Chest pain Influenza-like illness, pain
Croatian: Bolest slična gripi, bol
English: Suggested measures include induction of emesis and/or gastric lavage.
Croatian: Predložene mjere uključuju indukciju povraćanja i/ili ispiranje želuca.
English: Exacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazide diuretics, including hydrochlorothiazide.
Croatian: Egzercerbacija ili aktiviranje sistemskog lupus eritematozusa zabilježeno je s primjenom tiazidskih diuretika, uključujući hidroklorotiazid.
English: There is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with medicinal products that affect the renin-angiotensin-aldosterone system.
Croatian: Postoji povećani rizik od teške hipotenzije i renalne insuficijencije kada se bolesnici s bilateralnom stenozom bubrežne arterije ili stenozom arterije jedinog funkcionalnog bubrega liječe lijekovima koji utječu na sustav renin-angiotenzin-aldosteron.
English: No clear evidence of a teratogenic effect was observed, however at toxic dose levels of telmisartan an effect on the postnatal development of the offsprings such as lower body weight and delayed eye opening was observed.
Croatian: Međutim, pri toksičnim dozama telmisartana, primijećeni su učinci na postnatalni razvoj legla, kao što su niža tjelesna težina i odgođeno otvaranje očiju.
English: Sepsis* (often called "blood poisoning", is a severe infection with whole-body inflammatory response), rapid swelling of the skin and mucosa (angioedema), blistering and peeling of the top layer of skin (toxic epidermal necrolysis; these side effects are rare (may affect up to 1 in 1,000 people) or of unknown frequency (toxic epidermal necrolysis) but are extremely serious and patients should stop taking the medicine and see their doctor immediately.
Croatian: Sepsa* (često se naziva “trovanje krvi”) je teška infekcija s upalnom reakcijom cijelog tijela, brzo oticanje kože i sluznice (angioedem), stvaranje mjehura i ljuštenje gornjeg sloja kože (toksična epidermalna nekroliza); ove nuspojave su rijetke (mogu se javiti u do 1 na 1000 osoba) ili nepoznate učestalosti (toksična epidermalna nekroliza), ali izuzetno ozbiljne, te bolesnici moraju prekinuti s primjenom lijeka i trenutno se javiti liječniku.
English: In the PRoFESS trial, an increased incidence of sepsis was observed with telmisartan compared with placebo.
Croatian: U ispitivanju PRoFESS, primijećena je povećana incidencija sepse uz telmisartan u usporedbi s placebom.
English: Patients were randomized to one of the three following treatment groups: telmisartan 80 mg (n = 8542), ramipril 10 mg (n = 8576), or the combination of telmisartan 80 mg plus ramipril 10 mg (n = 8502), and followed for a mean observation time of 4.5 years.
Croatian: Bolesnici su randomizirani u jednu od sljedećih triju ispitivanih skupina: telmisartan 80 mg (n = 8542), ramipril 10 mg (n = 8576), ili kombinacija telmisartana 80 mg plus ramipril 10 mg (n = 8502), te su bili praćeni u prosječnom trajanju promatranja od 4,5 godina.
English: Kinzalkomb tablets are for once-daily oral administration and should be taken with liquid, with or without food.
Croatian: Kinzalkomb tablete namijenjene su peroralnoj primjeni jednom dnevno, te se moraju uzimati s tekućinom, s ili bez hrane.
English: Telmisartan selectively binds the AT1 receptor.
Croatian: Telmisartan selektivno veže AT1 receptor.
English: The concomitant use of Kinzalkomb with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1).
Croatian: Istodobna primjena Kinzalkomba s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem funkcije bubrega (GFR < 60 ml/min/1,73 m2) (vidjeti dijelove 4.5 i
English: When clinically appropriate, direct change from monotherapy to the fixed combination may be considered.
Croatian: Kada je to klinički odgovarajuće, može se razmotriti izravni prijelaz s monoterapije na fiksnu kombinaciju.
English: Thiazides should be discontinued before carrying out tests for parathyroid function.
Croatian: Mora se prekinuti terapija tiazidima prije ispitivanja funkcije paratireoidne žlijezde.
English: Telmisartan blocks the effect of angiotensin II so that the blood vessels relax, and your blood pressure is lowered.
Croatian: Telmisartan blokira učinak angiotenzina II tako što opušta krvne žile te je krvni tlak niži.
English: These patients can be expected to have reduced hepatic clearance for telmisartan.
Croatian: Kod takvih bolesnika očekuje se smanjeni jetreni klirens za telmisartan.
English: Thiazide-induced hypokalaemia or hypomagnesaemia favours the onset of digitalis-induced arrhythmia (see section 4.4).
Croatian: Hipokalemija ili hipomagnezemija inducirane tiazidima pogoduju nastupima aritmije uzrokovane digitalisom (vidjeti dio 4.4).
English: Periodic monitoring of renal function is advised (see section 4.4).
Croatian: Preporučuje se periodično praćenje bubrežne funkcije (vidjeti dio 4.4).
English: Kinzalkomb must not be used in patients with severe renal impairment (creatinine clearance <30 ml/min) (see section 4.3).
Croatian: Kinzalkomb ne smije se primjenjivati kod bolesnika s teškim oštećenjem funkcije bubrega (klirens kreatinina <30 ml/min) (vidjeti dio 4.3).
English: Kinzalkomb should not be given to patients with cholestasis, biliary obstructive disorders or severe hepatic insufficiency (see section 4.3) since telmisartan is mostly eliminated with the bile.
Croatian: Kinzalkomb ne smije se davati bolesnicima s kolestazom, bilijarnim opstruktivnim poremećajima ili teškom insuficijencijom jetre (vidjeti dio 4.3), s obzirom da se telmisartan uglavnom eliminira putem žuči.
English: Lupus-like syndrome, photosensitivity reactions, skin vasculitis, toxic epidermal necrolysis, erythema multiforme Musculoskeletal, connective tissue and bone disorders Not known:
Croatian: Sindrom nalik na lupus, reakcije fotoosjetljivosti, vaskulitis kože, toksična epidermalna nekroliza, multiformni eritem Poremećaji mišićno-koštanog sustava i vezivnog tkiva Nepoznato:
English: Most cases of hepatic function abnormal / liver disorder from post-marketing experience with telmisartan occurred in Japanese patients.
Croatian: Većina slučajeva abnormalne jetrene funkcije/poremećaja jetre iz iskustva u razdoblju nakon stavljanja telmisartana u promet pojavila se među japanskom populacijom.
English: Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (including hypokalaemia, hyponatraemia and hypochloraemic alkalosis).
Croatian: Tiazidi, uključujući hidroklorotiazid, mogu uzrokovati neravnotežu tekućine ili elektrolita (uključujući hipokalemiju, hiponatremiju i hipokloremičnu alkalozu).
English: Presumably through blockade of the reninangiotensin-aldosterone system, co-administration of telmisartan tends to reverse the potassium loss associated with these diuretics.
Croatian: Pretpostavlja se da putem blokade sustava renin-angiotenzin-aldosteron, istodobna primjena telmisartana ima tendenciju vraćanja gubitka kalija povezanog s ovim diureticima.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/02/214/011-015
Croatian: BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/02/214/011-015
English: Anticholinergic agents (e.g. atropine, biperiden) may increase the bioavailability of thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate.
Croatian: Antikolinergički lijekovi (npr. atropin, biperiden) mogu povećati bioraspoloživost diuretika tiazidskog tipa putem smanjenja gastrointestinalne pokretljivosti i brzine pražnjenja želuca.
English: Do not take Kinzalkomb
Croatian: Nemojte uzimati Kinzalkomb
English: Kinzalkomb is used to treat high blood pressure (essential hypertension) in adults whose blood pressure is not controlled enough when telmisartan is used alone.
Croatian: Kinzalkomb se primjenjuje u liječenju visokog krvnog tlaka (esencijalna hipertenzija) kod odraslih osoba čiji krvni tlak nije dobro kontroliran uz primjenu samog telmisartana.
English: Hydrochlorothiazide In patients taking hydrochlorothiazide alone the following additional side effects have been reported:
Croatian: Hidroklorotiazid Kod bolesnika koji uzimaju monoterapiju hidroklorotiazida prijavljene su sljedeće dodatne nuspojave.
English: As with any antihypertensive agent, excessive reduction of blood pressure in patients with ischaemic cardiopathy or ischaemic cardiovascular disease could result in a myocardial infarction or stroke.
Croatian: Kao i uz druge antihipertenzivne lijekove, pretjerano sniženje krvnog tlaka kod bolesnika s ishemijskom kardiopatijom ili ishemijskom kardiovaskularnom bolesti može rezultirati infarktom miokarda ili moždanim udarom.
English: • if you have severe liver problems such as cholestasis or biliary obstruction (problems with drainage of the bile from the liver and gall bladder) or any other severe liver disease.
Croatian: • ako imate teške jetrene tegobe kao što je kolestaza ili opstrukcija žuči (poteškoće s istjecanjem žuči iz jetre i žučnog mjehura) ili neku drugu tešku bolest jetre.
English: In some patients with compromised renal function (e.g. dehydrated patients or elderly patients with compromised renal function) the co-administration of angiotensin II receptor antagonists and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Croatian: Kod pojedinih bolesnika s kompromitiranom bubrežnom funkcijom (npr. dehidrirani bolesnici ili starije osobe s kompromitiranom bubrežnom funkcijom) istodobna primjena antagonista receptora angiotenzina II i lijekova koji inhibiraju ciklooksigenazu može rezultirati daljnjim pogoršanjem bubrežne funkcije, uključujući moguće akutno zatajenje bubrega, koje je obično reverzibilno.
English: Do not use this medicine after the expiry date which is stated on the carton after “EXP”.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake “Rok valjanosti”.
English: Cases of interstitial lung disease have been reported from post-marketing experience in temporal association with the intake of telmisartan.
Croatian: Slučajevi intersticijske bolesti pluća prijavljeni su iz iskustva tijekom razdoblja nakon stavljanja lijeka u promet, a u temporalnoj su vezi s unosom telmisartana.
English: Hydrochlorothiazide exhibits linear pharmacokinetics.
Croatian: Hidroklorotiazid pokazuje linearnu farmakokinetiku.
English: In patients with impaired renal function the rate of hydrochlorothiazide elimination is reduced.
Croatian: Kod bolesnika s oštećenom bubrežnom funkcijom brzina eliminacije hidroklorotiazida je smanjena.
English: Hydrochlorothiazide belongs to a group of medicines called thiazide diuretics, which cause your urine output to increase, leading to a lowering of your blood pressure.
Croatian: - Hidroklorotiazid pripada skupini lijekova koji se nazivaju tiazidski diuretici, koji uzrokuju povećano izlučivanje urina, što također snižava krvni tlak.
English: Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy
Croatian: Stenoza aortalnog i mitralnog zaliska, opstruktivna hipertrofična kardiomiopatija
English: This medicinal product contains lactose monohydrate and sorbitol.
Croatian: Ovaj lijek sadrži laktozu hidrat i sorbitol.
English: Should exposure to angiotensin II receptor antagonists have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Croatian: Ako dođe do izloženosti antagonistima receptora angiotenzina II od drugog tromjesečja trudnoće nadalje, preporučuje se ultrazvučni pregled bubrežne funkcije i lubanje.
English: • if you are taking any of the following medicines used to treat high blood pressure: - an ACE-inhibitor (for example enalapril, lisinopril, ramipril), in particular if you have diabetes-related kidney problems.
Croatian: • ako uzimate bilo koji od lijekova navedenih u nastavku, koji se koriste za liječenje visokog krvnog tlaka: - ACE inhibitor (primjerice enalapril, lizinopril, ramipril), osobito ako imate bubrežne tegobe povezane sa šećernom bolešću. - aliskiren.
English: When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started.
Croatian: Kada se trudnoća dijagnosticira, liječenje antagonistima receptora angiotenzina II mora se trenutno prekinuti, te, prema potrebi, početi sa zamjenskom terapijom.