FrancophonIA/ELRC3.0 huggingface dataset:
English: If a medicinal product that affects potassium levels is to be prescribed in combination with valsartan, monitoring of potassium plasma levels is advised.
Croatian: Ako se u kombinaciji s valsartanom propisuje lijek koji utječe na razine kalija, savjetuje se praćenje razina kalija u plazmi.
English: The amlodipine component of Dafiro inhibits the transmembrane entry of calcium ions into cardiac and vascular smooth muscle.
Croatian: Amlodipinska komponenta Dafira inhibira transmembranski ulaz iona kalcija u srčani mišić i glatki mišić krvnih žila.
English: Dual blockade of RAAS through the combined use of ACE inhibitors, ARBs or aliskiren is therefore not recommended (see sections 4.5 and 5.1).
Croatian: Dvostruka blokada RAAS-a kombiniranom primjenom ACE inhibitora, ARB-ova ili aliskirena stoga se ne preporučuje (vidjeti dijelove 4.5 i 5.1).
English: For convenience, patients receiving valsartan and amlodipine from separate tablets/capsules may be switched to Dafiro containing the same component doses.
Croatian: Bolesnici koji primaju valsartan i amlodipin u odvojenim tabletama/kapsulama, mogu se radi jednostavnosti prebaciti na Dafiro koji sadrži iste doze sastojaka.
English: In a long-term, placebo-controlled study (PRAISE-2) of amlodipine in patients with NYHA (New York Heart Association Classification) III and IV heart failure of non-ischaemic aetiology, amlodipine was associated with increased reports of pulmonary oedema despite no significant difference in the incidence of worsening heart failure as compared to placebo.
Croatian: U dugotrajnom, placebo-kontroliranom ispitivanju (PRAISE-2) amlodipina u bolesnika sa zatajivanjem srca ne-ishemijske etiologije III. i IV. stupnja prema NYHA (New York Heart Association Classification), amlodipin je bio povezan s povećanim brojem izvještaja o plućnom edemu, unatoč beznačajnoj razlici u incidenciji pogoršanja zatajivanja srca u usporedbi s placebom.
English: Intrahepatic cholestasis, jaundice
Croatian: Intrahepatična kolestaza, žutica
English: There is no experience of overdose with Dafiro.
Croatian: Nema iskustva s predoziranjem Dafirom.
English: Clinical data are insufficient regarding the potential effect of amlodipine on fertility.
Croatian: Nema dovoljno kliničkih podataka o mogućem učinku amlodipina na plodnost.
English: In patients with severe heart failure whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with ACE inhibitors and angiotensin receptor antagonists has been associated with oliguria and/or progressive azotaemia and (rarely) with acute renal failure and/or death.
Croatian: U bolesnika s teškim zatajivanjem srca čija funkcija bubrega može ovisiti o aktivnosti sustava renin-angiotenzin-aldosteron, liječenje ACE inhibitorima i antagonistima receptora angiotenzina bilo je povezano s oligurijom i/ili progresivnom azotemijom, i (rijetko) s akutnim zatajenjem bubrega i/ili smrću.
English: As with other calcium channel blockers, haemodynamic measurements of cardiac function at rest and during exercise (or pacing) in patients with normal ventricular function treated with amlodipine have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volume.
Croatian: Kao i kod drugih blokatora kalcijevih kanala, hemodinamska mjerenja srčane funkcije u mirovanju i tijekom opterećenja (ili tempiranog hoda) u bolesnika s normalnom funkcijom ventrikula liječenih amlodipinom pokazala su općenito mali porast srčanog indeksa bez značajnog utjecaja na dP/dt ili na krajnji dijastolički tlak lijevog ventrikula ili volumen lijevog ventrikula.
English: ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE inhibitor or an ARB in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both.
Croatian: ALTITUDE (eng. Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) je bilo ispitivanje osmišljeno za testiranje koristi dodavanja aliskirena standardnoj terapiji s ACE inhibitorom ili ARB-ovima u bolesnika sa šećernom bolešću tipa 2 i kroničnom bolešću bubrega, kardiovaskularnom bolešću ili oboje.
English: Peripheral oedema, a recognised side effect of amlodipine, was generally observed at a lower incidence in patients who received the amlodipine/valsartan combination than in those who received amlodipine alone.
Croatian: Periferni edem, kao poznata nuspojava amlodipina, općenito je opažen s nižom incidencijom u bolesnika koji su primali kombinaciju amlodipina/valsartana, nego u onih koji su primali samo amlodipin.
English: When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started.
Croatian: Kada se trudnoća utvrdi, liječenje AIIRA-om treba odmah prekinuti te, ako je prikladno, započeti alternativnu terapiju.
English: Mutagenicity studies revealed no drug related effects at either the gene or chromosome levels.
Croatian: Ispitivanja mutagenosti nisu otkrila nikakve učinke povezane s lijekom bilo na razini gena ili kromosoma.
English: The rate and extent of absorption of Dafiro are equivalent to the bioavailability of valsartan and amlodipine when administered as individual tablets.
Croatian: Brzina i opseg apsorpcije Dafira jednaki su bioraspoloživosti valsartana i amlodipina kada se primjenjuju kao pojedinačne tablete.
English: In one rat study, adverse effects were found on male fertility (see section 5.3).
Croatian: U jednom ispitivanju sa štakorima nađeni su štetni učinci na mušku plodnost (vidjeti dio 5.3).
English: Pack sizes: 56, 98 or 280 film-coated tablets.
Croatian: Veličina pakiranja: 56, 98 ili 280 filmom obloženih tableta.
English: Clinically significant hypotension due to Dafiro overdose calls for active cardiovascular support, including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulating fluid volume and urine output.
Croatian: Klinički značajna hipotenzija zbog predoziranja Dafirom zahtijeva aktivnu kardiovaskularnu potporu, uključujući često praćenje srčane i respiratorne funkcije, podizanje ekstremiteta, uz praćenje volumena cirkulirajuće tekućine i mokrenja.
English: In elderly patients, amlodipine clearance tends to decline, causing increases in the area under the curve (AUC) and elimination half-life.
Croatian: U starijih bolesnika postoji sklonost smanjenju klirensa amlodipina, što uzrokuje povećanja površine ispod krivulje (AUC) i poluvijeka eliminacije.
English: Quincke oedema
Croatian: Quinckeov edem
English: Dafiro should be used with caution to treat hypertension in patients with unilateral or bilateral renal artery stenosis or stenosis to a solitary kidney since blood urea and serum creatinine may increase in such patients.
Croatian: Dafiro se treba primjenjivati s oprezom u liječenju hipertenzije u bolesnika s jednostranom ili obostranom stenozom bubrežne arterije ili stenozom bubrežne arterije kod postojanja samo jednog bubrega budući da se u ovih bolesnika može povisiti urea u krvi i serumski kreatinin.
English: Urticaria and other forms of rash
Croatian: Urtikarija i drugi vrste osipa
English: Confusion.
Croatian: Konfuzija.
English: Valsartan belongs to a group of substances called “angiotensin-II receptor antagonists”.
Croatian: Valsartan pripada skupini tvari koje se nazivaju „antagonisti angiotenzin II receptora“.
English: Concomitant use of amlodipine with strong or moderate CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) may give rise to significant increase in amlodipine exposure.
Croatian: Istodobna primjena amlodipina sa snažnim ili umjerenim inhibitorima CYP3A4 (inhibitori proteaze, azolni antifungalni lijekovi, makrolidi kao eritromicin ili klaritromicin, verapamil ili diltiazem) mogu izazvati značajno povećanje izloženosti amlodipinu.
English: Among secondary endpoints, the incidence of heart failure (component of a composite combined cardiovascular endpoint) was significantly higher in the amlodipine group as compared to the chlorthalidone group (10.2% versus 7.7%, RR 1.38, 95% CI [1.25-1.52] p<0.001).
Croatian: Među sekundarnim ishodima incidencija zatajivanja srca (komponenta kompozita kombiniranog kardiovaskularnog ishoda) bila je značajno viša u skupini na amlodipinu u usporedbi sa skupinom koja je uzimala klortalidon (10,2% naspram 7,7%, OR 1,38, 95% CI [1,25-1,52] p<0,001).
English: This dose is 6 times the maximum recommended human dose on a mg/m basis
Croatian: Ta je doza 6 puta veća od najviše preporučene doze za ljude izražene u mg/m
English: In haemodynamic studies, amlodipine has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and humans, even when co-administered with beta blockers to humans.
Croatian: U hemodinamskim ispitivanjima, amlodipin nije bio povezan s negativnim inotropnim učinkom kada se primjenjivao u rasponu terapijskih doza zdravim životinjama i ljudima, čak i kada se u ljudi primjenjivao istodobno s beta-blokatorima.
English: In patients with an activated renin-angiotensin system (such as volume- and/or salt-depleted patients receiving high doses of diuretics) who are receiving angiotensin receptor blockers, symptomatic hypotension may occur.
Croatian: U bolesnika s aktiviranim renin-angiotenzinskim sustavom (poput bolesnika sa smanjenim volumenom tekućine i/ili sniženom razinom soli na visokim dozama diuretika) koji primaju blokatore angiotenzinskih receptora, može doći do simptomatske hipotenzije.
English: ACE inhibitors and ARBs should not be used concomitantly in patients with diabetic nephropathy.
Croatian: ACE inhibitori i ARB-ovi ne smiju se primjenjivati istodobno u bolesnika s dijabetičkom nefropatijom.
English: In clinical trials where valsartan was compared with an ACE inhibitor, the incidence of dry cough was significantly (p <0.05) lower in patients treated with valsartan than in those treated with an ACE inhibitor (2.6% versus 7.9%, respectively).
Croatian: U kliničkim ispitivanjima u kojima se valsartan uspoređivao s ACE inhibitorom, incidencija suhog kašlja bila je značajno (p <0,05) niža u bolesnika liječenih valsartanom, nego u onih liječenih ACE inhibitorom (2,6% naspram 7,9%).
English: The use of AIIRAs is contraindicated during the second and third trimesters of pregnancy (see sections 4.3 and 4.4).
Croatian: Primjena AIIRA je kontraindicirana tijekom drugog i trećeg tromjesečja trudnoće (vidjeti dijelove 4.3 i 4.4).
English: Adverse reactions previously reported with one of the individual components (amlodipine or valsartan) may be potential adverse reactions with Dafiro as well, even if not observed in clinical trials or during the post-marketing period.
Croatian: Dodatne informacije o pojedinačnim komponentama Nuspojave koje su ranije prijavljene s jednom od pojedinačnih komponenti (amlodipinom ili valsartanom) mogu biti i moguće nuspojave Dafira, iako nisu uočene u kliničkim ispitivanjima ili nakon stavljanja lijeka u promet.
English: In another rat study in which male rats were treated with amlodipine besilate for 30 days at a dose comparable with the human dose based on mg/kg, decreased plasma follicle-stimulating hormone and testosterone were found as well as decreases in sperm density and in the number of mature spermatids and Sertoli cells.
Croatian: U drugom ispitivanju sa štakorima u kojem su mužjaci 30 dana primali amlodipin bezilat u dozi usporedivoj s dozom za ljude izraženoj u mg/kg, nađeni su sniženi folikulostimulirajući hormon i testosteron u plazmi, kao i smanjenja gustoće sperme i smanjeni broj zrelih spermija i Sertolijevih stanica.
English: The primary endpoint was a composite of fatal coronary heart disease or non-fatal myocardial infarction.
Croatian: Primarni ishod bio je kompozit koronarne bolesti srca sa smrtnim ishodom ili infarkta miokarda bez smrtnog ishoda.
English: The patients had at least one additional coronary heart disease risk factor, including: previous myocardial infarction or stroke (>6 months prior to enrollment) or documentation of other atherosclerotic cardiovascular disease (overall 51.5%), type 2 diabetes (36.1%), high density lipoprotein - cholesterol <35 mg/dl or <0.906 mmol/l (11.6%), left ventricular hypertrophy diagnosed by electrocardiogram or echocardiography (20.9%), current cigarette smoking (21.9%).
Croatian: Bolesnici su imali najmanje jedan dodatni faktor rizika za koronarnu bolest srca, uključujući prethodni infarkt miokarda ili moždani udar (>6 mjeseci prije uključivanja u ispitivanje) ili dokumentaciju o drugoj aterosklerotskoj kardiovaskularnoj bolesti (ukupno 51,5%), šećernu bolest tipa 2 (36,1%), lipoprotein visoke gustoćekolesterol <35 mg/dl ili <0,906 mmol/l (11,6%), hipertrofiju lijevog ventrikula dijagnosticiranu elektrokardiogramom ili ehokardiografijom (20,9%), aktivni status pušača (21,9%).
English: In clinical interaction studies, amlodipine did not affect the pharmacokinetics of atorvastatin, digoxin, warfarin or ciclosporin.
Croatian: U kliničkim ispitivanjima interakcija, amlodipin nije utjecao na farmakokinetiku atorvastatina, digoksina, varfarina ili ciklosporina.
English: The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle, causing reductions in peripheral vascular resistance and in blood pressure.
Croatian: Mehanizam antihipertenzivnog djelovanja amlodipina je zbog direktnog relaksirajućeg učinka na glatki mišić krvnih žila, što uzrokuje smanjenje periferne vaskularne rezistencije i krvnog tlaka.
English: Calcium channel blockers, including amlodipine, should be used with caution in patients with congestive heart failure, as they may increase the risk of future cardiovascular events and mortality.
Croatian: Potreban je oprez prilikom primjene blokatora kalcijevih kanala, uključujući amlodipin, u bolesnika s kongestivnim zatajivanjem srca, jer mogu povećati rizik od budućih kardiovaskularnih događaja i smrtnosti.
English: Depression
Croatian: Depresija
English: Dafiro was also studied in an active-controlled study of 130 hypertensive patients with mean sitting diastolic blood pressure ≥110 mmHg and <120 mmHg.
Croatian: Dafiro je također ispitivan u aktivno kontroliranom kliničkom ispitivanju sa 130 hipertenzivnih bolesnika sa srednjom vrijednošću dijastoličkog krvnog tlaka u sjedećem položaju ≥110 mmHg i <120 mmHg.
English: In most patients, after administration of a single oral dose, onset of antihypertensive activity occurs within 2 hours, and the peak drop in blood pressure is achieved within 4-6 hours.
Croatian: U većine bolesnika nastup antihipertenzivne aktivnosti počinje unutar 2 sata nakon primjene jednokratne peroralne doze, a vršni pad krvnog tlaka postiže se unutar 4-6 sati.
English: Do not use any Dafiro pack that is damaged or shows signs of tampering.
Croatian: Ne koristiti Dafiro ako primijetite da je pakiranje oštećeno ili su vidljivi znakovi otvaranja.
English: Insomnia/sleep disorders
Croatian: Nesanica/poremećaji spavanja
English: There was no significant difference in the primary endpoint between amlodipine-based therapy and chlorthalidone-based therapy: risk ratio (RR) 0.98 95% CI (0.90-1.07) p=0.65.
Croatian: Nije bilo značajne razlike u primarnom ishodu između terapije temeljene na amlodipinu i terapije temeljene na klortalidonu: omjer rizika (OR) 0,98 95% CI (0,90-1,07) p=0,65.
English: MedDRA System organ class
Croatian: MedDRA Klasifikacija organskih sustava
English: The combination of amlodipine and valsartan produces dose-related additive reduction in blood pressure across its therapeutic dose range.
Croatian: Kombinacija amlodipina i valsartana dovodi do dodatnog sniženja krvnog tlaka povezanog s dozom unutar terapijskog raspona doze.
English: • Concomitant use of Dafiro with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m2) (see sections 4.5 and 5.1).
Croatian: • Istodobna primjena Dafira s lijekovima koji sadrže aliskiren kontraindicirana je u bolesnika sa šećernom bolešću ili oštećenjem bubrega (GFR <60 ml/min/1,73 m2) (vidjeti dijelove 4.5 i 5.1).
English: - Heart attack, abnormal heart beat.
Croatian: - Srčani udar, nepravilan rad srca.
English: The major symptom of overdose with valsartan is possibly pronounced hypotension with dizziness.
Croatian: Glavni simptom predoziranja valsartanom vjerojatno je izrazita hipotenzija s omaglicom.
English: The no-observed-effect-level for developmental effects was observed at 3- (valsartan) and 4- (amlodipine) fold the clinical exposure (based on AUC).
Croatian: Razina bez uočenih učinaka na razvojne poremećaje opažena je kod 3- (valsartan) i 4- (amlodipin) puta veće izloženosti od kliničke izloženosti (na temelju AUC-a).
English: • Severe hepatic impairment, biliary cirrhosis or cholestasis.
Croatian: • Teško oštećenje jetre, bilijarna ciroza ili kolestaza.
English: Side effects reported with amlodipine or valsartan alone and either not observed with Dafiro or observed with a higher frequency than with Dafiro:
Croatian: Prijavljene nuspojave s amlodipinom ili valsartanom primjenjenima samostalno ili uopće nisu opažene s Dafirom ili su opažene s većom učestalošću nego s Dafirom:
English: Very limited clinical data are available regarding amlodipine administration in patients with hepatic impairment.
Croatian: Dostupni su vrlo ograničeni klinički podaci o primjeni amlodipina u bolesnika s oštećenjem jetre.
English: Dual blockade of the RAAS with ARBs, ACE inhibitors or aliskiren Clinical trial data have shown that dual blockade of the RAAS through the combined use of ACE inhibitors, ARBs or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4 and 5.1).
Croatian: Dvostruka blokada RAAS s ARB-ovima, ACE inhibitorima ili aliskirenom Podaci iz kliničkih ispitivanja pokazali su da je dvostruka blokada RAAS kombiniranom primjenom ACE inhibitora, ARB-ova ili aliskirena povezana s većom učestalošću štetnih događaja kao što su hipotenzija, hiperkalemija i smanjena bubrežna funkcija (uključujući akutno zatajenje bubrega) u usporedbi s primjenom samo jednog lijeka koji djeluje na RAAS (vidjeti dijelove 4.3, 4.4 i 5.1).
English: If you stop taking Dafiro
Croatian: Ako prestanete uzimati Dafiro
English: Inhibitors of the uptake transporter (rifampicin, ciclosporin) or efflux transporter (ritonavir) The results of an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1 and of the hepatic efflux transporter MRP2.
Croatian: Inhibitori prijenosnika pohrane (rifampicin, ciklosporin) ili efluksnog prijenosnika (ritonavir) Rezultati in vitro ispitivanja na ljudskom tkivu jetre pokazuju da je valsartan supstrat jetrenog unosnog prijenosnika OATP1B1 i jetrenog efluksnog prijenosnika MRP2.
English: Interactions common to the combination
Croatian: Interakcije koje su česte kod ove kombinacije
English: - Inflamed pancreas, which may cause severe abdominal and back pain accompanied with feeling of being very unwell.
Croatian: - Upalu gušterače, koja može uzrokovati jake bolove u trbuhu i leđima pri čemu se bolesnik općenito osjeća vrlo loše.
English: Following oral administration of Dafiro, peak plasma concentrations of valsartan and amlodipine are reached in 3 and 6-8 hours, respectively.
Croatian: Nakon peroralne primjene Dafiroa, vršne koncentracije amlodipina i valsartana u plazmi postižu se u 3 odnosno 6-8 sati.
English: If you forget to take Dafiro
Croatian: Ako ste zaboravili uzeti Dafiro
English: Following intravenous administration, plasma clearance of valsartan is about 2 l/h and its renal clearance is 0.62 l/h (about 30% of total clearance).
Croatian: Nakon intravenske primjene, klirens valsartana iz plazme je oko 2 l/h, dok je njegov bubrežni klirens 0,62 l/h (oko 30% ukupnog klirensa).
English: In monotherapy with valsartan, no interactions of clinical significance have been found with the following substances: cimetidine, warfarin, furosemide, digoxin, atenolol, indometacin, hydrochlorothiazide, amlodipine, glibenclamide.
Croatian: Kod monoterapije valsartanom nisu nađene klinički značajne interkacije sa sljedećim lijekovima: cimetidin, varfarin, furosemid, digoksin, atenolol, indometacin, hidroklorotiazid, amlodipin, glibenklamid.
English: Monitoring of potassium levels and creatinine is advised in moderate renal impairment.
Croatian: Savjetuje se praćenje razina kalija i kreatinina kod umjerenog oštećenja bubrega.
English: Novartis Farmacéutica SA Ronda de Santa Maria 158 08210 Barberà del Vallès, Barcelona Spain
Croatian: 08210 Barberà del Vallès, Barcelona Španjolska
English: Patients with high cardiovascular risks - heart failure, type I and poorly controlled type II diabetes and history of myocardial infarction or stroke within one yearwere excluded.
Croatian: Bolesnici s visokim kardiovaskularnim rizicima - zatajivanje srca, tip I i loše kontrolirani tip II šećerne bolesti, kao i s infarktom miokarda ili moždanim udarom unutar godinu dana u anamnezi - bili su isključeni iz ispitivanja.
English: Exposure to AIIRA therapy during the second and third trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see section 5.3).
Croatian: Poznato je da izloženost terapiji AIIRA-ima tijekom drugog i trećeg tromjesečja u ljudi izaziva fetotoksičnost (smanjenu funkciju bubrega, oligohidramnione, retardaciju okoštavanja lubanje) i neonatalnu toksičnost (zatajenje bubrega, hipotenziju, hiperkalijemiju) (vidjeti dio 5.3).
English: If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Croatian: Ako imate dodatnih pitanja u vezi s primjenom ovog lijeka, obratite se svom liječniku ili ljekarniku.
English: If any of the above applies to you, do not take Dafiro and talk to your doctor.
Croatian: Ako se bilo što od navedenog odnosi na Vas, nemojte uzeti Dafiro i obavijestite svog liječnika.
English: There is evidence that the concomitant use of ACE inhibitors, ARBs or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure).
Croatian: Postoje dokazi da istodobna primjena ACE inhibitora, ARB-ova ili aliskirena povećava rizik od hipotenzije, hiperkalemije i smanjene bubrežne funkcije (uključujući akutno zatajenje bubrega).
English: if your doctor has told you that you have a narrowing of the valves in your heart (called “aortic or mitral stenosis”) or that the thickness of your heart muscle is abnormally increased (called “obstructive hypertrophic cardiomyopathy”).
Croatian: Liječnik može također provjeriti funkciju Vaših bubrega. ako Vam je liječnik rekao da imate suženje srčanih zalistaka (zvano „aortalna ili mitralna stenoza“) ili da je debljina vašeg srčanog mišića nenormalno povećana (zvano „opstruktivna hipertrofična kardiomiopatija“).
English: Ten per cent of original amlodipine and 60% of amlodipine metabolites are excreted in urine.
Croatian: Mokraćom se izlučuje deset posto originalnog amlodipina i 60% metabolita amlodipina.
English: Blood creatinine increased
Croatian: Povišen kreatinin u krvi
English: In hypertensive patients with normal renal function, therapeutic doses of amlodipine resulted in a decrease in renal vascular resistance and an increase in glomerular filtration rate and effective renal plasma flow, without change in filtration fraction or proteinuria.
Croatian: U hipertenzivnih bolesnika s normalnom bubrežnom funkcijom, terapijske doze amlodipina rezultiraju smanjenjem bubrežne vaskularne rezistencije i povećanjem brzine glomerularne filtracije te učinkovitim protokom plazme kroz bubreg, bez promjene u filtracijskom udjelu ili proteinurije.
English: Leukopenia
Croatian: Leukopenija