FrancophonIA/ELRC3.0 huggingface dataset:
English: No dedicated fertility studies have been conducted with mifamurtide (see section 5.3).
Danish: Ingen særlige fertilitetsstudier er blevet udført for mifamurtid (se pkt.
English: If you have worsening symptoms, you should contact your doctor, as these may have been caused by MEPACT.
Danish: Hvis du har forværrede symptomer, bør du kontakte din læge, da disse symptomer muligvis kan have været forårsaget af MEPACT.
English: Administration of mifamurtide was commonly associated with transient neutropenia, usually when used in conjunction with chemotherapy.
Danish: Indgivelse af mifamurtid var ofte forbundet med forbigående neutropeni, som regel ved anvendelse sammen med kemoterapi.
English: Occasional allergic reactions have been associated with mifamurtide treatment, including rash, shortness of breath and grade 4 hypertension (see section 4.8).
Danish: Mifamurtid-behandlingen har undertiden været forbundet med allergiske reaktioner, herunder udslæt, kortåndethed og grad 4-hypertension (se pkt.
English: The recommended dose of MEPACT is 2 mg mifamurtide/m body surface area.
Danish: Den anbefalede dosis af MEPACT er 2 mg mifamurtid/m legemsoverfladeareal.
English: Association of mifamurtide with signs of pronounced inflammatory response, including pericarditis and pleuritis, was uncommon.
Danish: I sjældne tilfælde var der en sammenhæng mellem mifamurtid og tegn på udtalt inflammatorisk respons, herunder pericarditis og pleuritis.
English: Mean half-lives of total and free MTP-PE in mild hepatic impairment were 2.02 hours and 1.99 hours, respectively, and were comparable to those in subjects with normal hepatic function (2.15 hours and 2.26 hours, respectively).
Danish: De gennemsnitlige halveringstider for total og fri MTP-PE ved let leverinsufficiens var henholdsvis 2,02 timer og 1,99 timer og var sammenlignelige med halveringstiderne hos forsøgspersoner med normal leverfunktion (henholdsvis 2,15 timer og 2,26 timer).
English: The patient experienced shaking, chills, fever, nausea, vomiting, uncontrollable coughing, shortness of breath, cyanotic lips, dizziness, weakness, hypotension, tachycardia, hypertension and hypothermia leading to study discontinuation.
Danish: Patienten oplevede rysten, kulderystelser, feber, kvalme, opkastninger, ukontrollerbar hoste, åndenød, cyanotiske læber, svimmelhed, svaghed, hypotension, takykardi, hypertension og hypotermi, hvilket medførte studieophør.
English: Talk to your doctor before using MEPACT: if you have or have had problems with your heart or blood vessels, like blood clots (thrombosis), bleeding (haemorrhage) or inflammation of the veins (vasculitis).
Danish: Advarsler og forsigtighedsregler: Kontakt lægen, før du bruger MEPACT: - hvis du har eller har haft problemer med dit hjerte eller blodkar som f.eks. blodpropper (trombose) eller blødninger eller betændelse i venerne (vaskulitis), skal du overvåges mere nøje, mens du bliver behandlet med MEPACT.
English: Additionally, the geometric mean plasma AUCinf of free (non-liposome associated) MTP-PE in mild and moderate hepatic impairment were 47% higher than the corresponding values in the matched normal hepatic function groups.
Danish: Desuden var den geometriske middelværdi for plasma-AUCinf af fri (ikke-liposom-associeret) MTP-PE ved let og moderat leverinsufficiens 47 % højere end den tilsvarende værdi i den matchede gruppe med normal leverfunktion.
English: Confusional state, Depression, Insomnia, Anxiety
Danish: Forvirring, depression, søvnløshed, ængstelighed
English: What MEPACT contains - The active substance is mifamurtide.
Danish: MEPACT indeholder: - Aktivt stof: mifamurtid.
English: The recommended dose of mifamurtide for all patients is 2 mg/m body surface area.
Danish: Den anbefalede dosis af mifamurtid for alle patienter er 2 mg/m legemsoverfladeareal.
English: 50 mL type I glass vial with a grey butyl rubber stopper, aluminium seal and plastic flip-off cap, containing 4 mg of mifamurtide.
Danish: 50 ml hætteglas af type I med en grå butylgummiprop, aluminiumssegl og aftagelig plastikhætte indeholdende 4 mg mifamurtid.
English: It is unknown whether mifamurtide is excreted in human milk.
Danish: Det vides ikke, hvorvidt mifamurtid udskilles i human modermælk.
English: • Sodium chloride 9 mg/mL (0.9%) solution for injection, 100 mL bag
Danish: • Natriumklorid 9 mg/ml (0,9 %) opløsning til injektion, 100 ml pose
English: In vitro interaction studies showed that liposomal and non-liposomal mifamurtide do not inhibit the metabolic activity of cytochrome P450 in pooled human liver microsomes.
Danish: In-vitro-interaktionsstudier viste, at liposomal og non-liposomal mifamurtid ikke hæmmer den metaboliske aktivitet af cytokrom P450 i poolede humane levermikrosomer.
English: Haemorrhage was observed in animals at very high doses.
Danish: Ved meget høje doser blev der observeret blødninger hos dyr.
English: The lyophilised powder should be allowed to reach a temperature between approximately 20 C-25 °C prior to reconstitution, filtering using the filter provided and dilution.
Danish: Det frysetørrede pulver bør inden opløsning, filtrering og fortynding nå en temperatur på mellem ca. 20 C - 25 °C.
English: It is recommended that the reconstitution of the liposomal suspension should be performed in a laminar flow cabinet utilising sterile gloves using aseptic technique.
Danish: Det anbefales, at den liposomale suspension blandes i et stinkskab/kabine med laminar-flow (LAF) med sterile handsker og under aseptiske forhold.
English: If you have long-lasting or worsening symptoms, you should contact your doctor, as MEPACT treatment may need to be delayed or discontinued.
Danish: Hvis symptomerne varer længe eller forværres, bør du kontakte lægen, da behandlingen med MEPACT i så tilfælde måske skal udsættes eller afbrydes.
English: The no-adverse-effect level for mifamurtide in animals corresponds roughly to the 2 mg/m2 recommend dose for humans.
Danish: Det niveau, hvor der ikke blev observeret bivirkninger af mifamurtid til dyr, svarer nogenlunde til den anbefalede dosis for mennesker på 2 mg/m
English: The filter luer connector cap should not be removed at this time.
Danish: Fjern ikke filter-luerlock-forbindelseshætten på dette tidspunkt.
English: Before using MEPACT, you should discuss with your doctor whether you should take medicine for your asthma when using MEPACT.
Danish: Før behandlingen, bør du spørge din læge, om du skal tage din astmamedicin, mens du behandles med MEPACT.
English: There was no effect of mild (50 mL/min ≤ creatinine clearance [CLcr] ≤ 80 mL/min) or moderate (30 mL/min ≤ CLcr < 50 mL/min) renal insufficiency on the clearance of total MTP-PE, when compared with that observed in healthy adult subjects with normal renal function (CLcr > 80 mL/min).
Danish: Let (50 ml/min ≤ kreatininclearance [CrCL] ≤ 80 ml/min) eller moderat (30 ml/min ≤ CrCL < 50 ml/min) nyreinsufficiens havde ingen effekt på clearance af total-MTP-PE ved sammenligning med raske voksne forsøgspersoner med normal nyrefunktion (CrCL > 80 ml/min).
English: Do not refrigerate or freeze the solution.
Danish: Opløsningen må ikke opbevares i køleskab og må ikke nedfryses.
English: In vivo administration of mifamurtide resulted in the inhibition of tumour growth in mouse and rat models of lung metastasis, skin and liver cancer, and fibrosarcoma.
Danish: In vivo indgivelse af mifamurtid resulterede i hæmmet tumorvækst i modeller af lungemetastase, hud- og leverkræft samt fibrosarcoma hos mus og rotter.
English: The syringe should then be removed from the filter and a new needle placed on the suspension-filled syringe.
Danish: Sprøjten fjernes derefter fra filteret, og en ny kanyle sættes på sprøjten, som er fyldt med suspension.
English: You may experience more severe side effects, including fever, chills, fatigue, nausea, vomiting, headache and high blood pressure or low blood pressure.
Danish: Du kan komme ud for mere alvorlige bivirkninger, herunder feber, kuldegysninger, træthed, kvalme, opkastning, hovedpine og for højt eller for lavt blodtryk.
English: • 1 single use 60 or 100 mL sterile syringe with luer lock
Danish: • 1 steril engangs-luerlock-sprøjte til 60 eller 100 ml
English: Unopened vial of powder
Danish: Uåbnet hætteglas med pulver
English: Once reconstituted in sodium chloride 9 mg/mL (0.9%) solution, store at room temperature (approximately 20ºC - 25ºC) and use within 6 hours.
Danish: Efter opløsning i en natriumkloridopløsning på 9 mg/ml (0,9 %) opbevares blandingen ved stuetemperatur (ca. 20 ºC - 25 ºC) og anvendes inden for 6 timer.
English: Other generalised symptoms that were typically mild to moderate and very common included hypothermia (23%), malaise (13%), pain (15%), asthenia (13%) and chest pain (11%).
Danish: Andre generaliserede symptomer, der typisk var lette til moderate og meget almindelige, omfattede hypotermi (23 %), utilpashed (13 %), smerter (15 %), asteni (13 %) og smerter i brystet (11 %).
English: Rash, Pruritis, Erythema, Alopecia, Dry skin
Danish: Udslæt, pruritus, erythema, alopeci, tør hud
English: Gastrointestinal disorders were frequently associated with mifamurtide administration, including nausea (57%) and vomiting (44%) in about half of patients, constipation (17%), diarrhoea (13%) and abdominal pain (see section 4.4).
Danish: Forstyrrelser i mave-tarmkanalen blev ofte forbundet med indgivelse af mifamurtid, herunder kvalme (57 %) og opkastning (44 %) hos ca. halvdelen af patienterne, forstoppelse (17 %), diarré (13 %) og smerter i maven (se pkt.
English: Powder for concentrate for dispersion for infusion 4 mg mifamurtide
Danish: Pulver til koncentrat til infusionsvæske, dispersion 4 mg mifamurtid
English: The freeze-dried powder has to be reconstituted into a liquid suspension, filtered using the filter provided and further diluted before use.
Danish: Det frysetørrede pulver skal rekonstitueres til en flydende suspension, som filtreres med brug af det medfølgende filter og yderligere fortyndes, før det indgives.
English: Very common side effects (may affect more than 1 in 10 people): - fever, shaking/shivering, weakness, tiredness or general discomfort - nausea and/or vomiting, diarrhoea or constipation - headache or dizziness - rapid beating of the heart - high blood pressure or low blood pressure - no appetite for food - sweating - pain, including general pain, pain in your muscles and/or joints and pain in back, chest,
Danish: Meget almindelige bivirkninger (kan forekomme hos mere end 1 ud af 10 behandlede): - feber, rysten/kulderystelser, svaghed, træthed eller almindeligt ubehag - kvalme og/eller opkastning, diarré eller forstoppelse - hovedpine eller svimmelhed - hurtig puls - højt blodtryk eller lavt blodtryk - ingen appetit - svedafsondring - smerte, herunder generel smerte, smerter i muskler og/eller led og smerte i ryg, bryst, mave,
English: Skin and subcutaneous disorders Hyperhidrosis (11%) was very common in patients receiving mifamurtide in uncontrolled studies.
Danish: Hyperhidrose (11 %) var meget almindelig hos patienter, der fik mifamurtid i ukontrollerede studier.
English: MEPACT is then infused directly into your vein (intravenous) over about 1 hour.
Danish: Du får MEPACT intravenøst (direkte i din vene) i løbet af ca. 1 time.
English: Concurrent use with high-dose non-steroidal-anti-inflammatory drugs (NSAIDs, cyclooxygenase inhibitors) (see section 4.5).
Danish: Samtidig anvendelse af høje doser non-steroide antiinflammatoriske lægemidler (NSAID'er, cyclooxygenase-hæmmere) (se pkt.
English: Anaemia has very commonly been reported when mifamurtide is used in conjunction with chemotherapeutic agents.
Danish: Anæmi indberettes meget ofte, når mifamurtidanvendes sammen med kemoterapi.
English: The volume of reconstituted suspension corresponding to the calculated dose is extracted through the filter provided and further diluted with additional 50 mL sodium chloride 9 mg/mL (0.9%) solution for injection according to the detailed instructions shown below.
Danish: Mængden af opløst suspension, som svarer til den beregnede dosis, udvindes gennem det medfølgende filter og fortyndes yderligere med endnu en 50 ml natriumklorid 9 mg/ml (0,9 %) opløsning til injektion efter de detaljerede instruktioner nedenfor.
English: Therefore, the use of high-dose NSAIDs is contraindicated (see section 4.3).
Danish: Derfor kontraindiceres anvendelsen af højdosis NSAID-præparater (se pkt.
English: Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Danish: Bivirkningerne er inden for hver enkelt frekvensgruppe opstillet efter, hvor alvorlige de er.
English: • MEPACT powder for concentrate for dispersion for infusion (vial)
Danish: • MEPACT pulver til koncentrat til infusionsvæske, dispersion (hætteglas)
English: A higher percentage of objective and subjective hearing loss was observed overall in patients who received MEPACT and chemotherapy (12% and 4%, respectively) in the phase III study (see section 5.1 for a description of the study) compared to those patients that received only chemotherapy (7% and 1%).
Danish: Der blev generelt observeret en højere procentdel af objektivt og subjektivt høretab hos patienter, som fik MEPACT og kemoterapi (henholdsvis 12 % og 4 %) i fase III-studiet (se en beskrivelse af studiet i pkt.
English: For convenience, the following table of concordance is provided:
Danish: For nemheds skyld medfølger denne dosistabel:
English: It is recommended to separate the times of administration of MEPACT and doxorubicin or other medicines if used in the same chemotherapy treatment regimen.
Danish: Det anbefales at give MEPACT, doxorubicin eller andre typer medicin, der anvendes i samme kemoterapibehandling på forskellige tidspunkter.
English: Nausea, vomiting and loss of appetite are very common adverse reactions to mifamurtide (see section 4.8).
Danish: Kvalme, opkastning og appetitløshed er meget almindelige bivirkninger af mifamurtid (se pkt.
English: For intravenous use after reconstitution, filtering using the filter provided and further dilution.
Danish: Til intravenøs brug efter rekonstitution, filtrering gennem det medfølgende filter og yderligere fortynding.
English: Continued monitoring of the kidney and liver function is recommended if mifamurtide is used beyond completion of chemotherapy until all therapy is completed.
Danish: Hvis mifamurtid anvendes, efter kemoterapien er afsluttet, anbefales det at fortsætte monitoreringen af nyre- og leverfunktionen, indtil hele behandlingen er afsluttet.
English: Common side effects (may affect up to 1 in 10 people): - blue colour of tissues such as the skin or gums caused by too little oxygen - perceptible increase in frequency or force of heartbeat - swelling in arms or legs or other swelling - chest discomfort - upset stomach, decreased appetite or weight loss - injection site or catheter site redness, swelling, infection or other local reaction - rash or redness, inflammation of the skin, itching, dry skin, pale or transient red appearance - inflammation of skin, tendons, muscles or similar tissues that support body structure - inflammation of a vein - upper abdominal or chest wall pain; abdominal bloating or pain; indigestion or pain in your liver - other pain, including neck, shoulder, groin, bone or throat pain; pain after an operation - muscle spasms or stiffness - feeling cold - tired feeling, drowsiness or sleepiness - burning, pricking/tingling sensation, diminished sensitivity to sensation or feeling a sensation without stimulus - involuntary shaking movement - dehydration - low concentration of potassium in blood - mucosal inflammation - nose, throat, or sinus congestion or inflammation - infections of the upper respiratory tract (such as a cold) or the urinary tract (such as a bladder infection) - generalised infection - Herpes simplex (virus) infection - productive cough, wheezing or exertional or exacerbated shortness of breath - spitting of blood or nosebleed - fluid in the lung cavity - blood in urine, difficulty or pain in urination or frequent urination - difficulty sleeping, depression, anxiety or confusion - dizziness - ears ringing - blurred vision - hair loss - difficult, painful menstruation - hearing loss - low number of white blood cells with or without fever, low number of platelets
Danish: smerter som efter en operation - muskelkramper eller stivhed - kuldefølelse - træthedfølelse, døsighed eller søvnighed - brænden, prikkende/snurrende følelse, nedsat følesans eller sådanne følelser uden stimulation - ufrivillig rysten - dehydrering - lav kaliumkoncentration i blodet - betændelse i slimhinder - tilstoppet næse, hals eller bihuler eller betændelse - infektioner i de øvre luftveje (som f.eks. en forkølelse) eller urinvejene (som f.eks. en blærebetændelse) - generel infektion - forkølelsessår - hoste med slim, hvæsende vejrtrækning eller besværet vejrtrækning ved anstrengelse - blodigt spyt eller næseblod - væske i lungehulrummet - blod i urinen, vanskelighed eller smerter ved vandladning eller hyppig vandladning - søvnbesvær, depression, ængstelighed eller forvirring - svimmelhed - ringen for øret - sløret syn - hårtab - vanskelig, smertefuld menstruation - høretab - et lavt antal hvide blodlegemer med eller uden feber, lavt antal blodplader
English: See section 2 “MEPACT contains sodium”
Danish: 2 Mepact indeholder natrium”.
English: What MEPACT looks like and contents of the pack MEPACT is a white to off-white homogeneous cake or powder for concentrate for dispersion for infusion.
Danish: Udseende og pakningsstørrelser MEPACT er et hvidt eller off-white ensartet pulver til koncentrat til infusionsvæske, dispersion.
English: The pharmacokinetics of a single 4 mg dose of mifamurtide following a 1 hour intravenous infusion were evaluated in adult volunteers with mild (n = 9) or moderate (n = 8) renal impairment and in age-, sex-, and weight-matched healthy adults with normal renal function (n = 16).
Danish: Mifamurtids farmakokinetik efter en enkelt dosis på 4 mg givet over 1 time som intravenøs infusion blev evalueret hos voksne frivillige forsøgspersoner med let (n = 9) eller moderat (n = 8) nyreinsufficiens og hos raske voksne med normal nyrefunktion, der matchede i alder og vægt (n = 16).
English: It is not known whether MEPACT passes to human milk.
Danish: Man ved ikke, om MEPACT udskilles i modermælk.
English: Sepsis, Cellulitis, Nasopharyngitis, Catheter site infection, Upper respiratory tract infection, Urinary tract infection, Pharyngitis, Herpes simplex infection
Danish: Blodforgiftning, cellulitis, nasofaryngitis, infektion på kateterstedet, infektion i de øvre luftveje, urinvejsinfektion, faryngitis, Herpes simplex-infektion
English: The pharmacokinetics of a single 4 mg dose of mifamurtide following a 1 hour intravenous infusion were evaluated in adult volunteers with mild (Child-Pugh class A; n = 9) or moderate (Child-Pugh class B; n = 8) hepatic impairment and in age, sex-, and weight-matched healthy adults with normal hepatic function (n = 19).
Danish: Mifamurtids farmakokinetik efter en enkelt 4 mg dosis mifamurtid givet over 1 time som intravenøs infusion blev evalueret hos voksne frivillige forsøgspersoner med let (Child-Pugh klasse A; n = 9) eller moderat (Child-Pugh klasse B; n = 8) leverinsufficiens og hos raske voksne med normal leverfunktion, der matchede i alder og vægt (n = 19).
English: If you are breast-feeding, you should discuss with your doctor.
Danish: Hvis du ammer, skal du tale med lægen.
English: The bag injection site should be wiped with an alcohol pad and the suspension in the syringe should be injected into the original bag containing the remaining 50 mL of sodium chloride 9 mg/mL (0.9%) solution for injection (figure 4).
Danish: Rens det sted på posen, hvor kanylen indføres med en spritpude, og sprøjt suspensionen i sprøjten ind i den oprindelige pose, som indeholder de resterende 50 ml af natriumklorid 9 mg/ml (0,9 %) injektionsopløsning (figur 4).
English: Musculoskeletal and connective tissue disorders Low grade pain was very common in patients receiving mifamurtide, including myalgia (31%), back pain (15%), extremity pain (12%) and arthralgia (10%).
Danish: Lette smerter var meget almindelig hos patienter, der fik mifamurtid, herunder myalgi (31 %), rygsmerter (15 %), ekstremitetssmerter (12 %) og artralgi (10 %).
English: Haematuria, Dysuria, Pollakiuria
Danish: Hæmaturi, dysuri, pollakisuri
English: The sodium chloride 9 mg/mL (0.9%) solution for injection is added to the vial by slow, firm depression of the syringe plunger.
Danish: Den 9 mg/ml (0,9 %) injektionsopløsning af natriumklorid føjes til hætteglasset ved at trykke sprøjtens stempel ned med en langsom, fast bevægelse.
English: Additionally, the systemic exposures AUC from zero to infinity (AUCinf of free (non-liposome associated) MTP-PE in mild or moderate renal insufficiency were similar to those observed in healthy adult subjects with normal renal function.
Danish: Desuden svarede den systemiske eksponering AUCinf (arealet under kurven fra nul til uendelig) for fri (ikke-liposom-associeret) MTP-PE hos personer med let eller moderat nyreinsufficiens til eksponeringen hos raske voksne forsøgspersoner med normal nyrefunktion.
English: Paraesthesia, Hypoaesthesia, Tremor, Somnolence, Lethargy
Danish: Paræstesi, hypæstesi, tremor, døsighed, letargi
English: Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2).
Danish: Lægemidlet må kun udleveres efter ordination på en særlig recept udstedt af en begrænset lægegruppe (se bilag I: Produktresumé, pkt.
English: Volume
Danish: Mængde
English: 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine monosodium salt (OOPS)
Danish: 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine mononatriumsalt (OOPS)
English: How to use MEPACT
Danish: Sådan skal du bruge MEPACT
English: The most frequent adverse reactions are chills, pyrexia, fatigue, nausea, tachycardia and headache.
Danish: De hyppigste bivirkninger er kulderystelser, feber, træthed, kvalme, takykardi og hovedpine.
English: The filter should be removed from the blister pack, and the cap removed from the filter spike.
Danish: Fjern filteret fra blisterpakken og låget fra filterspidsen.
English: MEPACT must be reconstituted, filtered using the filter provided and further diluted using aseptic technique, prior to administration.
Danish: MEPACT skal under aseptiske forhold opløses, filtreres gennem det medfølgende filter og fortyndes yderligere før administration.
English: Concurrent use with ciclosporin or other calcineurin inhibitors (see section 4.5).
Danish: Samtidig anvendelse af ciclosporin eller andre calcineurinhæmmere (se pkt.
English: Upper abdominal pain, Dyspepsia, Abdominal distension, Lower abdominal pain
Danish: Smerter i øverste del af maven, dyspepsi, abdominal distension, smerter i nederste del af maven
English: Some very common and common side effects of MEPACT treatment (such as dizziness, vertigo, fatigue and blurred vision) may affect your ability to drive and use machines.
Danish: MEPACT-behandlingen giver i mange tilfælde bivirkninger (som svimmelhed, træthed og sløret syn), som kan påvirke arbejdssikkerheden og evnen til at færdes sikkert i trafikken.
English: Each vial contains 4 mg of mifamurtide.
Danish: Hvert hætteglas indeholder 4 mg mifamurtid.
English: Pleural effusion, Exacerbated dyspnoea, Productive cough, Haemoptysis, Wheezing, Epistaxis, Exertional dyspnoea, Sinus congestion, Nasal congestion, Pharyngolaryngeal pain
Danish: Pleural effusion, forværret dyspnø, produktiv hoste, hæmoptyse, hvæsende vejrtrækning, epistaxis, anstrengelsesdyspnø, tilstoppede bihuler, tilstoppet næse, pharyngolaryngeal smerte
English: Excipients: Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine monosodium salt (OOPS)
Danish: Hjælpestoffer: Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-Dioleoylsn-glycero-3-phospho-L-serine mononatriumsalt (OOPS)
English: The excretion of mifamurtide in milk has not been studied in animals.
Danish: Det er ikke undersøgt, hvorvidt mifamurtid udskilles i modermælken hos dyr.