FrancophonIA/ELRC3.0 huggingface dataset:
English: Austria, Belgium/Luxembourg, Bulgaria, Cyprus, Germany, Denmark, Estonia, Greece, Finland, France, Hungary, Ireland, Italy, Lithuania, Latvia, Malta, Netherlands, Poland, Portugal, Romania, Slovenia, Spain, Sweden, United Kingdom, Iceland, Norway
Slovenian: COZAAR 2,5 mg/ml prašek in vehikel za peroralno suspenzijo v Avstriji, v Belgiji/Luksemburgu, v Bolgariji, na Cipru, na Danskem, v Estoniji, na Finskem, v Franciji, v Grčiji, na Irskem, na Islandiji, v Italiji, v Latviji, v Litvi, na Madžarskem, na Malti, v Nemčiji, na Nizozemskem, na Norveškem, na Poljskem, na Portugalskem, v Romuniji, v Sloveniji, v Španiji, na Švedskem, v Veliki Britaniji.
English: Your doctor will decide on the appropriate dose of COZAAR, depending on your condition and whether you are taking other medicines.
Slovenian: Zdravnik vam bo predpisal ustrezen odmerek zdravila COZAAR glede na vaše stanje in glede na to, ali jemljete še katera druga zdravila.
English: H-1123 Budapest, Hungary
Slovenian: H-1123 Budimpešta, Madžarska
English: For patients who can swallow tablets, this dosage form is also available.
Slovenian: Za bolnike, ki lahko pogoltnejo tablete, je na voljo tudi taka farmacevtska oblika.
English: Losartan may be administered with or without food.
Slovenian: Losartan se lahko zaužije s hrano ali brez nje.
English: Measures are depending on the time of medicinal product intake and kind and severity of symptoms.
Slovenian: Ukrepi so odvisni od časa zaužitja ter vrste in jakosti simptomov.
English: Taking other medicines: Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or herbal medicines and natural products.
Slovenian: Jemanje drugih zdravil Obvestite svojega zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katerokoli drugo zdravilo, vključno s tistimi, ki ste jih dobili brez recepta ali zdravili rastlinskega izvora in naravnimi izdelki.
English: 75114 Paris Cedex 08, France
Slovenian: 75114 Paris Cedex 08, Francija
English: Side effects in children are similar to those seen in adults.
Slovenian: Neželeni učinki pri otrocih so podobni tistim, ki so jih opazili pri odraslih.
English: 1407 Sofia, Bulgaria
Slovenian: 1407 Sofija, Bolgarija
English: • reduced number of thrombocytes,
Slovenian: • zmanjšano število trombocitov
English: 00-867 Warsaw, Poland
Slovenian: 00-867 Varšava, Poljska
English: The patients should have a left ventricular ejection fraction ≤ 40 % and should be stabilised under the treatment of the chronic heart failure.
Slovenian: Bolniki morajo imeti iztisno frakcijo levega prekata ≤ 40 % in morajo biti stabilni ob zdravljenju kroničnega srčnega popuščanja.
English: • inflammation of blood vessels (vasculitis including Henoch-Schönlein purpura),
Slovenian: • vnetje krvnih žil (vaskulitis, vključno s Henoch-Schönlein purpuro)
English: • if you are breast-feeding (see also "Pregnancy and breast-feeding").
Slovenian: • če dojite (glejte tudi "Nosečnost in dojenje").
English: Very rare cases have also been reported with angiotensin II receptor antagonists.
Slovenian: O zelo redkih primerih so poročali tudi pri antagonistih angiotenzina II.
English: Therefore, concomitant use is not recommended (see section 4.5).
Slovenian: Zato sočasne uporabe ne priporočamo (glejte poglavje 4.5).
English: The frequency of adverse events listed below is defined using the following convention: very common (≥ 1/10); common (≥ 1/100, to < 1/10); uncommon (≥ 1/1,000, to < 1/100); rare (≥ /10,000, to < 1/1,000); very rare (< 1/10,000), not known (cannot be estimated from the available data).
Slovenian: Pogostnost spodaj naštetih neželenih učinkov je označena v skladu z naslednjim dogovorom: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), pogostnost neznana (iz razpoložljivih podatkov se je ne da določiti).
English: You should not take losartan in the first 12 weeks of pregnancy, and you must not take it at all after the 13th week as its use during pregnancy may possibly be harmful to the baby.
Slovenian: Losartana naj se v prvih 12 tednih nosečnosti ne bi jemalo, od 13. tedna dalje pa je njegova uporaba celo prepovedana, ker lahko škoduje otroku.
English: Use in children and adolescents COZAAR has been studied in children.
Slovenian: Uporaba pri otrocih in mladostnikih Zdravilo COZAAR so preizkušali pri otrocih.
English: In controlled clinical trials, clinically important changes in standard laboratory parameters were rarely associated with administration of Losartan tablets.
Slovenian: V kontroliranih kliničnih preskušanjih so bile klinično pomembne spremembe standardnih laboratorijskih parametrov redko povezane z uporabo tablet z losartanom.
English: Infants whose mothers have taken losartan should be closely observed for hypotension.
Slovenian: Otroke, katerih matere so prejemale losartan, je treba pozorno spremljati zaradi možnosti pojava hipotenzije.
English: Do not take a double dose to make up for a forgottendose.
Slovenian: Ne vzemite dvojnega odmerka, da bi nadomestili pozabljenega.
English: The observation of the ELITE Study, that, compared with captopril, Losartan reduced the mortality risk, was not confirmed in the subsequent ELITE II Study, which is described in the following.
Slovenian: Opažanje iz študije ELITE, da je losartan v primerjavi s kaptoprilom zmanjšal tveganje za smrt, v naslednji študiji ELITE II, ki je opisana v nadaljevanju, ni bilo potrjeno.
English: Other warnings and precautions:
Slovenian: Druga opozorila in previdnostni ukrepi
English: For reconstitution see section 6.6.
Slovenian: Za navodila za pripravo glejte poglavje 6.6.
English: Whilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor Inhibitors (AIIRAs), similar risks may exist for this class of medicinal products.
Slovenian: Čeprav ni na voljo kontroliranih epidemioloških podatkov glede tveganja pri uporabi antagonistov angiotenzina II (AIIRA-jev), lahko podobno tveganje obstaja tudi za to skupino zdravil.
English: Dosage should be adjusted according to blood pressure response.
Slovenian: Odmerek je treba prilagoditi glede na odziv krvnega tlaka.
English: MSD Hungary Ltd 50, Alkotas str.
Slovenian: Madžarska MSD Hungary Ltd 50, Alkotas str.
English: Important information about some of the ingredients of COZAAR COZAAR contains lactose monohydrate and sorbitol.
Slovenian: Pomembne informacije o nekaterih sestavinah zdravila COZAAR Zdravilo COZAAR vsebuje laktozo monohidrat in sorbitol.
English: Patients with a history of angiooedema (swelling of the face, lips, throat, and/ or tongue) should be closely monitored (see section 4.8).
Slovenian: Bolnike, ki so kdaj imeli angioedem (otekanje obraza, ustnic, žrela in/ali jezika), je treba pozorno spremljati (glejte poglavje 4.8).
English: The pharmacokinetic parameters for the metabolite differed to a greater extent between the age groups.
Slovenian: Farmakokinetični parametri presnovka so se med različnimi starostnimi skupinami bolj razlikovali.
English: However, when driving vehicles or operating machines it must be borne in mind that dizziness or drowsiness may occasionally occur when taking antihypertensive therapy, in particular during initiation of treatment or when the dose is increased.
Slovenian: Vendar pa je pri vožnji ali upravljanju s stroji treba upoštevati, da se pri antihipertenzivnem zdravljenju občasno lahko pojavi omotica ali dremavost, še posebej na začetku zdravljenja ali pri povečanju odmerka.
English: Although consideration should be given to initiating therapy with 25 mg in patients over 75 years of age, dosage adjustment is not usually necessary for the elderly.
Slovenian: Za bolnike, starejše od 75 let, je treba razmisliti o začetku zdravljenja s 25 mg odmerkom, vendar pa prilagoditev odmerjanja pri starejših običajno ni potrebna.
English: Hyperkalaemia (serum potassium >5.5 mmol/l) occurred in 1.5 % of patients in hypertension clinical trials.
Slovenian: Hiperkaliemija (vrednost serumskega kalija > 5,5 mmol/l) se je pojavila pri 1,5 % bolnikov iz kliničnih preskušanj hipertenzije.
English: The results showed roughly similar pharmacokinetic parameters of losartan following oral administration in infants and toddlers, preschool children, school-age children and adolescents.
Slovenian: Rezultati so pokazali, da so farmakokinetični parametri losartana po peroralni aplikaciji pri dojenčkih in malčkih, predšolskih otrocih, šoloobveznih otrocih in mladostnikih približno podobni.
English: The lowest doses studied, 2.5 mg and 5 mg, corresponding to an average daily dose of 0.07 mg/ kg, did not appear to offer consistent antihypertensive efficacy.
Slovenian: Najmanjša preizkušana odmerka, 2,5 mg in 5 mg, ki ustrezata povprečnima dnevnima odmerkoma 0,07 mg/kg, nista imela dosledne antihipertenzivne učinkovitosti.
English: Both Losartan and its principal active metabolite have a far greater affinity for the AT1-receptor than for the AT2-receptor.
Slovenian: Oba, losartan in njegov osnovni aktivni presnovek, imata precej večjo afiniteto za AT1 receptor kot za AT2 receptor.
English: The systemic bioavailability of losartan tablets is approximately 33 %.
Slovenian: Sistemska biološka uporabnost losartana je približno 33 %.
English: Turn the whole thing to an upright position.
Slovenian: Vse skupaj spet obrnite v pokončen položaj.
English: Elevations of ALT occurred rarely and usually resolved upon discontinuation of therapy.
Slovenian: Povišanja vrednosti ALT so bila redka in so se običajno popravila po prekinitvi zdravljenja.
English: SPECIAL STORAGE CONDITIONS Store in the original container.
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte v originalni ovojnini.
English: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.- Viale Shakespeare 47, 00144 Rome, Italy
Slovenian: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.- Viale Shakespeare 47, 00144 Rim, Italija
English: Other antihypertensive agents may increase the hypotensive action of losartan.
Slovenian: Drugi antihipertenzivi lahko povečajo hipotenzivni učinek losartana.
English: ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM(S), STRENGTH(S), ROUTE(S) OF ADMINISTRATION OF THE MEDICINAL PRODUCT(S), MARKETING AUTHORISATION HOLDER(S) IN THE MEMBER STATES
Slovenian: DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, PREDLAGATELJEV, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
English: Angioedema.
Slovenian: Angioedem.
English: Following an oral dose/intravenous administration of 14C-labeled losartan in man, about 35 % / 43 % of radioactivity is recovered in the urine and 58 %/ 50 % in the faeces.
Slovenian: Po peroralnem/intravenskem odmerku s 14C označenega losartana pri človeku najdemo približno 35 % / 43 % radioaktivnosti v urinu, 58 % / 50 % pa v blatu.
English: Like all medicines, COZAAR can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo COZAAR neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: To be prepared by medical or healthcare professionals only.
Slovenian: Zdravilo lahko pripravi samo zdravstveno osebje.
English: COZAAR is unlikely to affect your ability to drive or use machines.
Slovenian: Zelo malo verjetno je, da bi zdravilo COZAAR vplivalo na sposobnost vožnje in upravljanja s stroji.
English: There are limited data on the efficacy and safety of losartan in children and adolescents aged 6-16 years old for the treatment of hypertension (see section 5.1).
Slovenian: Podatkov o učinkovitosti in varnosti losartana za zdravljenje hipertenzije pri otrocih in mladostnikih, starih 6 do 16 let, je malo (glejte poglavje 5.1).
English: Measurements of blood pressure 24 hours post-dose relative to 5 - 6 hours post-dose demonstrated blood pressure reduction over 24 hours; the natural diurnal rhythm was retained.
Slovenian: Meritve krvnega tlaka 24 ur po odmerku so v primerjavi z meritvami 5 - 6 ur po odmerku pokazale 24-urno znižanje krvnega tlaka; ohranjen je bil naravni vsakodnevni ritem.
English: The European Medicines Agency has deferred the obligation to submit the results of studies with <Cozaar and associated names - See Annex I - To be completed nationally> in one or more subsets of the paediatric population in Hypertension, Proteinuria.
Slovenian: Evropska agencija za zdravila je odložila obvezo po predaji rezultatov študije hipertenzije in proteinurije z zdravilom <COZAAR in povezana imena - glejte Dodatek I - izpolni država članica> v eni ali več podskupin pediatrične populacije.
English: • Hypersensitivity to the active substance or to any of the excipients (see section 4.4 and 6.1).
Slovenian: • Preobčutljivost za zdravilno učinkovino ali katerokoli pomožno snov (glejte poglavji 4.4 in 6.1).
English: Carefully add the complete contents of the sachet into the PET container bottle containing the solvent, tapping the side of the sachet and inverting as necessary.
Slovenian: Previdno dodajte celotno vsebino vrečke v PET plastenko, ki vsebuje vehikel, tako da potrkavate po eni strani vrečke in jo po potrebi obračate.
English: Limited pharmacokinetic data are available in hypertensive children above one month of age (see section 5.2).
Slovenian: Farmakokinetičnih podatkov pri otrocih s hipertenzijo, starih več kot en mesec, je malo na voljo (glejte poglavje 5.2).
English: Patients with rare hereditary problems of fructose intolerance should not take this medicine.
Slovenian: Bolniki z redko dedno intoleranco za fruktozo tega zdravila ne smejo jemati.
English: Administration of the oral suspension
Slovenian: Uporaba peroralne suspenzije
English: COZAAR also contains methylhydroxybenzoate and propylhydroxybenzoate, which may cause allergic reactions (possibly delayed).
Slovenian: COZAAR vsebuje tudi metilhidroksibenzoat in propilhidroksibenzoat, ki lahko povzročata alergijske reakcije (lahko zapoznele).
English: • In a controlled clinical trial in 177 hypertensive pediatric patients 6 to 16 years of age
Slovenian: • V kontroliranem kliničnem preskušanju pri 177 hipertenzivnih pediatričnih bolnikih, starih 6 do 16 let
English: Blood pressure may also be lowered by one of the following drugs/ class of drugs: tricyclic antidepressants, antipsychotics, baclofene, amifostine.
Slovenian: Krvni tlak vam lahko zniža tudi katero od naslednjih zdravil/skupin zdravil: triciklični antidepresivi, antipsihotiki, baklofen, amifostin.
English: In the treatment of heart failure, losartan is usually combined with a diuretic (medicine that increases the amount of water that you pass out through your kidneys) and/or digitalis (medicine that helps to make the heart stronger and more efficient) and/or a beta-blocker.
Slovenian: Pri zdravljenju srčnega popuščanje se losartan običajno kombinira z diuretikom (zdravilo, ki poveča količino vode, ki se izloči skozi ledvice) in/ali digitalisom (zdravilo, ki pripomore, da je srce močnejše in učinkovitejše) in/ali beta zaviralcem.
English: Renal function should be regularly monitored during treatment with losartan as it may deteriorate.
Slovenian: Med zdravljenjem z losartanom je treba redno kontrolirati delovanje ledvic, ker se lahko poslabša.
English: COZAAR powder and solvent for oral suspension is packaged in a kit containing:
Slovenian: COZAAR prašek in vehikel za peroralno suspenzijo je pakiran tako, da vsebuje:
English: What COZAAR is and what it is used for Before you take COZAAR How to take COZAAR Possible side effects How to store COZAAR Further information
Slovenian: Kaj je zdravilo COZAAR in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo COZAAR Kako jemati zdravilo COZAAR Možni neželeni učinki
English: PHARMACEUTICAL FORM AND CONTENTS 473 ml solvent
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA 473 ml vehikla
English: It is normal to have a small amount of residual powder adhering to the interior surfaces of the sachet.
Slovenian: Normalno je, da nekaj praška ostane na notranjih površinah vrečke.
English: • 2nd and 3rd trimester of pregnancy (see section 4.6).
Slovenian: • Drugo in tretje trimesečje nosečnosti (glejte poglavje 4.6).
English: Compared to patients with normal renal function, the AUC for Losartan is about 2times higher in haemodialysis dialysis patients.
Slovenian: V primerjavi z bolniki z normalno ledvično funkcijo je pri bolnikih na hemodializi AUC losartana približno 2-krat večja.
English: Data in the pediatric population are limited.
Slovenian: Podatkov za pediatrične bolnike je malo.
English: These results were confirmed during period II of the study where patients were randomized to continue losartan or placebo, after three weeks of treatment.
Slovenian: Ti rezultati so bili potrjeni po treh tednih v drugem obdobju študije, v kateri so bolnike randomizirali tako, da so nadaljevali zdravljenje z losartanom ali pa prejemali placebo.
English: This pack contains:
Slovenian: Pakiranje vsebuje:
English: • Lactation (see section 4.6).
Slovenian: • Dojenje (glejte poglavje 4.6).
English: In these clinical trials, the most common adverse event was dizziness.
Slovenian: V teh kliničnih preskušanjih je bil najpogostejši neželeni učinek omotica.
English: When pregnancy is diagnosed, treatment with losartan should be stopped immediately and, if appropriate, alternative therapy should be started.
Slovenian: Ob potrjeni nosečnosti je treba zdravljenje z losartanom takoj prekiniti in, če je primerno, začeti alternativno zdravljenje.
English: Do not use COZAAR after the expiry date which is stated on the carton after EXP.
Slovenian: Zdravila COZAAR ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli poleg oznake "Uporabno do".
English: What COZAAR looks like and contents of the pack
Slovenian: Izgled zdravila COZAAR in vsebina pakiranja
English: 12.5 mg and 50 mg (initiation pack)
Slovenian: 12.5 mg and 50 mg (začetno pakiranje)
English: • if you suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of the hormone aldosterone by the adrenal gland, caused by an abnormality within the gland).
Slovenian: • če imate primarni hiperaldosteronizem (sindrom povezan s povečanim izločanjem hormona aldosterona iz nadledvične žleze zaradi okvare znotraj železe).
English: If you forget to take COZAAR
Slovenian: Če ste pozabili vzeti zdravilo COZAAR
English: • Reduction in the risk of stroke in adult hypertensive patients with left-ventricular hypertrophy documented by ECG (see section 5.1 LIFE study, Race).
Slovenian: • Zmanjšanje tveganja za možgansko kap pri odraslih hipertenzivnih bolnikih s hipertrofijo levega prekata, potrjeno z EKG-jem (glejte poglavje 5.1 Študija LIFE, Rasa).
English: Adult Patients with Heart Failure
Slovenian: Odrasli bolniki s srčnim popuščanjem
English: [See Annex I - To be completed nationally] {Name and address} <{tel}> <{fax}> <{e-mail}>
Slovenian: [Glejte Dodatek I - Izpolni država članica] {Ime in naslov} <{tel}> <{fax}> <{e-naslov}>
English: An increased mortality was observed in ELITE II in the small subgroup (22 % of all HF patients) taking beta-blockers at baseline.
Slovenian: Povečano smrtnost so opazili v majhni podskupini bolnikov iz študije ELITE II (22 % vseh bolnikov s srčnim popuščanjem), ki so na začetku jemali beta zaviralce.
English: When losartan is administered orally, about 4 % of the dose is excreted unchanged in the urine, and about 6 % of the dose is excreted in the urine as active metabolite.
Slovenian: Po peroralnem odmerku losartana se približno 4 % zaužitega odmerka izloči v urin nespremenjenega, približno 6 % zaužitega odmerka pa v obliki aktivnega presnovka.
English: Remove the syringe and take the medicine.
Slovenian: Odstranite brizgo in vzemite zdravilo.
English: • Treatment of chronic heart failure (in patients ≥ 60 years), when treatment with Angiotensinconverting enzyme (ACE) inhibitors is not considered suitable due to incompatibility, especially cough, or contraindication.
Slovenian: • Zdravljenje kroničnega srčnega popuščanja (pri bolnikih ≥ 60 let) kadar zdravljenje z zaviralci angiotenzinske konvertaze (ACE) ni primerno zaradi inkompatibilnosti, posebno kašlja, ali kontraindikacije.
English: Do not take:
Slovenian: Ne jemljite zdravila:
English: A medical or healthcare professional/pharmacist mixes each sachet with 200 ml of solvent to create a suspension.
Slovenian: Zdravstveno osebje/farmacevt zmeša eno vrečko praška z 200 ml vehikla, da nastane suspenzija.
English: In patients with heart failure, with or without renal impairment, there is - as with other medicinal products acting on the renin-angiotensin system - a risk of severe arterial hypotension, and (often acute) renal impairment.
Slovenian: Pri bolnikih s srčnim popuščanjem z okvaro ledvic ali brez obstaja, tako kot pri drugih zdravilih, ki delujejo na sistem renin-angiotenzin, tveganje za hudo arterijsko hipotenzijo in (pogosto akutno) ledvično okvaro.
English: In a clinical trial it was found that fluconazole (inhibitor of CYP2C9) decreases the exposure to the active metabolite by approximately 50 %.
Slovenian: V kliničnem preskušanju so ugotovili, da flukonazol (zaviralec CYP2C9) zmanjšuje izpostavljenost aktivnemu presnovku za približno 50 %.
English: Kit: Do not store above 25°C.
Slovenian: Škatla z zdravilom in opremo: Ne shranjujte pri temperaturi nad 25 ºC.
English: Take particular care if you are taking the following medicines while under treatment with COZAAR:
Slovenian: Še posebej pozorni bodite, če med zdravljenjem z zdravilom COZAAR jemljete katero od naslednjih zdravil:
English: Concomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.
Slovenian: Sočasna uporaba antagonistov angiotenzina II ali diuretikov in NSAID-ov lahko poveča tveganje za poslabšanje ledvične funkcije, vključno z možno akutno ledvično odpovedjo, ter poveča količino kalija v serumu, še posebej pri bolnikih z že obstoječim slabim delovanjem ledvic.
English: Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system.
Slovenian: Bolniki s primarnim hiperladosteronizmom se na zdravljenje z antihipertenzivi, ki zavirajo sistem renin-angiotenzin, večinoma ne odzovejo.
English: For the following individual and combined components of the primary endpoint, the results showed a significant risk reduction in the group treated with Losartan: 25.3 % risk reduction for doubling of the serum creatinine (p = 0.006); 28.6 % risk reduction for end-stage renal failure (p = 0.002); 19.9 % risk reduction for end-stage renal failure or death (p = 0.009); 21.0 % risk reduction for doubling of serum creatinine or end-stage renal failure (p = 0.01).
Slovenian: V skupini, ki se je zdravila z losartanom, se je pomembno zmanjšalo tveganje za naslednje posamezne komponente primarnega opazovanega dogodka in njihove kombinacije: 25,3 % zmanjšanje tveganja za podvojitev kreatinina v serumu (p = 0,006); 28,6 % zmanjšanje tveganja za končno ledvično odpoved (p = 0,002), 19,9 % zmanjšanje tveganja za končno ledvično odpoved ali smrt (p = 0,009), 21,0 % zmanjšanje tveganja za podvojitev kreatinina v serumu ali končno ledvično odpoved (p = 0,01).
English: • Treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus with proteinuria ≥ 0.5 g/day as part of an antihypertensive treatment.
Slovenian: • Zdravljenje bolezni ledvic pri odraslih bolnikih s hipertenzijo in sladkorno boleznijo tipa 2 s proteinurijo ≥ 0,5 g/dan kot del antihipertenzivnega zdravljenja.
English: Co-administration of lithium and losartan should be undertaken with caution.
Slovenian: Pri sočasni uporabi litija in losartana je potrebna previdnost.
English: • very rapid and irregular heartbeat (atrial fibrillation) brain attack (stroke),
Slovenian: • zelo hitro in neredno bitje srca (atrijska fibrilacija), možganska kap
English: Both losartan and its active metabolite are ≥99 % bound to plasma proteins, primarily albumin.
Slovenian: Tako losartan kot njegov aktivni presnovek sta v ≥ 99 % vezana na plazemske proteine, predvsem na albumin.