FrancophonIA/ELRC3.0 huggingface dataset:
English: Consideration should be given to possible effects on the central nervous system.
Croatian: Potrebno je razmotriti moguće učinke na središnji živčani sustav.
English: Such information will allow your doctor to decide whether a dose reduction is needed.
Croatian: Na osnovu tih informacija liječnik će odlučiti je li potrebno smanjiti dozu.
English: During the infusion at the hospital the following allergic reactions may occur (may affect more than 1 in 10 people):
Croatian: Tijekom infuzije u bolnici mogu se javiti sljedeće alergijske reakcije (javljaju se u više od 1 na 10 osoba):
English: North Harrow, Middlesex HA1 4HF United Kingdom
Croatian: North Harrow, Middlesex HA1 4HF Ujedinjeno Kraljevstvo
English: Accord (listed in section 6).
Croatian: (naveden u dijelu 6).
English: The amount of alcohol in this medicine may have effects on the central nervous system (the part of the nervous system that includes the brain and spinal cord).
Croatian: Količina alkohola u ovom lijeku može utjecati na središnji živčani sustav (dio živčanog sustava koji uključuje mozak i kralježničnu moždinu).
English: In case of vision problems, in particular blurred vision, you should immediately have your eyes and vision examined.
Croatian: U slučaju problema s vidom, naročito zamagljenog vida, trebate odmah otići na pregled očiju i vida.
English: The safety and efficacy of docetaxel in nasopharyngeal carcinoma in children aged 1 month to less than 18 years have not yet been established.
Croatian: Sigurnost i djelotvornost docetaksela u nazofaringealnom karcinomu u djece starosti od 1 mjeseca do 18 godina nisu još ustanovljene.
English: What Docetaxel Accord is and what it is used for
Croatian: Što je Docetaxel Accord i za što se koristi
English: Your doctor may stop your treatment immediately.
Croatian: Moguće je da će Vaš liječnik odmah prekinuti Vaše liječenje.
English: • decrease of the sodium, potassium, magnesium, and/or calcium in your blood (electrolyte balance disorders).
Croatian: • smanjenje razina natrija, kalija, magnezija i/ili kalcija u krvi (poremećaji ravnoteže elektrolita).
English: You must not become pregnant during treatment with this medicine and must use an effective method of contraception during therapy, because docetaxel may be harmful for the unborn baby.
Croatian: Ne smijete zatrudnjeti tijekom uzimanja ovog lijeka i morate provoditi učinkovite mjere kontracepcije tijekom liječenja, jer docetaksel može biti štetan za nerođeno dijete.
English: • raised liver enzymes (hence the need for regular blood tests)
Croatian: • povišeni jetreni enzimi (potrebne redovite krvne pretrage).
English: Store in the original package in order to protect from light.
Croatian: Čuvati u originalnom pakiranju, radi zaštite od svjetlosti.
English: permanent hair loss has been observed
Croatian: (nepoznata učestalost) zabilježen je trajan gubitak kose
English: The hospital staff will monitor your condition closely during treatment.
Croatian: Vaše stanje pomno će nadzirati medicinsko osoblje za vrijeme liječenja.
English: It is important that you read the entire contents of this guide prior to the preparation of the Docetaxel Accord infusion solution.
Croatian: Važno je pročitati cijeli sadržaj ove upute prije pripreme Docetaxel Accord infuzijske otopine.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Croatian: Od zdravstvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijavljivanja: navedenog u Dodatku V.
English: Docetaxel Accord contains alcohol.
Croatian: Docetaxel Accord sadrži alkohol.
English: If you develop acute or worsening problems with your lungs (fever, shortness of breath or cough), please tell your doctor, hospital pharmacist or nurse immediately.
Croatian: Ako Vam se jave akutni problemi ili Vam se pogoršaju postojeći problemi s plućima (vrućica, nedostatak zraka ili kašalj), molimo odmah obavijestite svog liječnika, bolničkog ljekarnika ili medicinsku sestru.
English: The incidence of serious adverse events was higher in elderly compared to younger patients.
Croatian: Incidencija ozbiljnih nuspojava bila je veća u starijih osoba u odnosu na mlađe osobe.
English: Pharmacotherapeutic group: Antineoplastic agents, plant alkaloids and other natural products, Taxanes, ATC Code: L01CD02
Croatian: Farmakoterapijska skupina: antineoplastici, biljni alkaloidi i drugi biljni pripravci, taksani, ATK oznaka: L01CD02.
English: Prepare the infusion solution as recommended.
Croatian: Pripremite infuzijsku otopinu na način na koji je to preporučeno.
English: If the patient continues to experience these reactions at 60 mg/m2, the treatment should be discontinued.
Croatian: Ako se u bolesnika pri primjeni doze od 60 mg/m2 i dalje javljaju ove reakcije, liječenje treba prekinuti.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 May 2012
Croatian: Datum prvog odobrenja: 22. svibnja 2012
English: Before each treatment with Docetaxel Accord, you will have blood tests to check that you have enough blood cells and sufficient liver function to receive Docetaxel Accord.
Croatian: Prije svake primjene lijeka Docetaxel Accord, obavit ćete krvne pretrage kako bi se provjerilo imate li dovoljno krvnih stanica te odgovarajuću funkciju jetre kako biste mogli primiti Docetaxel Accord.
English: Your doctor may change the dose and frequency of dosing depending on your blood tests, your general condition and your response to Docetaxel Accord.
Croatian: Vaš liječnik može mijenjati dozu i učestalost primjene lijeka ovisno o rezultatima krvnih pretraga, Vašem općem stanju i terapijskom odgovoru na Docetaxel Accord.
English: No studies on the effects on the ability to drive and use machines have been performed.
Croatian: Nisu provedena ispitivanja o utjecaju na sposobnost upravljanja vozilima i rada a strojevima.
English: Docetaxel Accord will be given by infusion into one of your veins (intravenous use).
Croatian: Docetaxel Accord ćete dobiti infuzijom u jednu od vena (intravenska primjena).
English: If new or worsening pulmonary symptoms develop, patients should be closely monitored, promptly investigated, and appropriately treated.
Croatian: Ako se jave novi ili pogoršaju postojeći simptomi plućnih bolesti, potrebno je pozorno pratiti bolesnike, brzo provesti pretrage i primjereno ih liječiti.
English: • weight gain or loss
Croatian: • dobitak ili gubitak na težini.
English: The main test method used to determine HER2 positivity in this pivotal study was immunohistochemistry (IHC).
Croatian: Glavna test metoda za određivanje pozitivnog HER2 u ovoj temeljnoj studiji bila je imunohistokemijska metoda (engl. immunohistochemistry, IHC).
English: • if you are allergic (hypersensitive) to docetaxel or any of the other ingredients of Docetaxel
Croatian: • ako ste alergični (preosjetljivi) na docetaksel ili neki drugi sastojak lijeka Docetaxel Accord
English: Treatment difference: 7.1% [95% CI: 0.7; 13.5] *: Corrected for multiple comparisons and adjusted for stratification factors (stage of disease and region of treatment), based on evaluable patient population.
Croatian: Razlika u liječenju: 7,1% [95% CI: 0,7; 13,5] * Korigirano za višestruku usporedbu i prilagođeno faktorima stratifikacije (stupanj bolesti i regija liječenja) na osnovu podataka iz populacije bolesnika koji su se mogli procijeniti
English: See also section “Docetaxel Accord contains ethanol (alcohol)” below.
Croatian: Također pogledajte dio "Docetaxel Accord sadrži etanol (alkohol)" niže.
English: Docetaxel Accord will be administered to you by a healthcare professional.
Croatian: Docetaxel Accord će Vam davati zdravstveni radnik.
English: Overall response rate (%):
Croatian: Ukupni terapijski odgovor (%):
English: The performance status scale, for head and neck (PSS-HN) subscales designed to measure understandability of speech, ability to eat in public, and normalcy of diet, was significantly in favour of TPF as compared to PF.
Croatian: Ljestvica izvedbenog statusa, odnosno pomoćne ljestvice za glavu i vrat (engl. performance status scale for head and neck, PSS-HN), koja mjeri razumijevanje govora, sposobnost uzimanja jela u javnosti i normalnost ishrane, bile su značajno u korist TPF u odnosu na PF.
English: What Docetaxel Accord is and what it is used for What you need to know before you use Docetaxel Accord How to use Docetaxel Accord Possible side effects
Croatian: Što je Docetaxel Accord i za što se koristi Što morate znati prije nego počnete primjenjivati Docetaxel Accord Kako primjenjivati Docetaxel Accord Moguće nuspojave
English: Other medicines and Docetaxel Accord
Croatian: Drugi lijekovi i Docetaxel Accord
English: Discuss with your doctor if you suffer from alcohol dependency, epilepsy or liver impairment.
Croatian: Razgovarajte sa svojim liječnikom ako ste ovisni o alkoholu, imate epilepsiju ili oštećenje funkcije jetre.
English: Overall response rate (CR+PR) (%) p-value
Croatian: Stopa ukupnog odgovora (CR+PR) (%) p-vrijednost
English: TAC = docetaxel, doxorubicin and cyclophosphamide FAC = 5-fluorouracil, doxorubicin and cyclophospamide CI = confidence interval; ER = oestrogen receptor PR = progesterone receptor a ER/PR-negative or Grade 3 or tumour size >5 cm
Croatian: TAC = docetaksel, doksorubicin i ciklofosfamid FAC = 5-fluorouracil, doksorubicin i ciklofosfamid CI = interval pouzdanosti; ER = estrogenski receptor PR = progesteronski receptor a ER/PR-negativni ili gradus 3 ili veličina tumora >5 cm
English: 2-year estimate (%)
Croatian: dvogodišnje preživljenje (%)
English: OTHER SPECIAL WARNING(S), IF NECESSARY CYTOTOXIC
Croatian: DRUGA POSEBNA UPOZORENJE(A), AKO JE POTREBNO CITOTOKSIČNO
English: For docetaxel/carboplatin combination, neither equivalent nor non-inferior efficacy could be proven compared to the reference treatment combination VCis.
Croatian: Za kombinaciju docetaksel/karboplatin nije se mogla dokazati jednaka ili neinferiorna djelotvornost u usporedbi s referentnom kombinacijom liječenja VCis.
English: How to store Docetaxel Accord Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati Docetaxel Accord Lijek čuvajte izvan pogleda i dohvata djece.
English: Overall, quality of life (QoL) and clinical benefit results consistently indicated improvement in favour of the TCF arm.
Croatian: Općenito, kvaliteta života (engl. quality of life, QoL) i rezultati kliničke koristi dosljedno su pokazali poboljšanje u korist TCF skupine.
English: FAC (n=521)
Croatian: (n=521)
English: You will be asked to take premedication consisting of an oral corticosteroid such as dexamethasone, one day prior to Docetaxel Accord administration and to continue for one or two days after it in order to minimise certain undesirable effects which may occur after the infusion of Docetaxel Accord in particular allergic reactions and fluid retention (swelling of the hands, feet, legs or weight gain).
Croatian: Od Vas će se tražiti da uzmete premedikaciju koja se sastoji od oralnih kortikosteroida, poput deksametazona, dan prije primjene lijeka Docetaxel Accord te još dan ili dva nakon toga, kako bi se smanjile određene nuspojave, koje se mogu pojaviti nakon infuzije lijeka Docetaxel Accord, osobito alergijske reakcije i zadržavanje tekućine u tijelu (oticanje ruku, stopala, nogu ili povećanje tjelesne težine).
English: • interstitial lung disease (inflammation of the lungs causing coughing and difficulty breathing.
Croatian: • intersticijska bolest pluća (upala pluća koje uzrokuje kašalj i otežano disanje.
English: Docetaxel Accord contains ethanol (alcohol)
Croatian: Docetaxel Accord sadrži etanol (alkohol)
English: • injection site reactions at the site of a previous reaction.
Croatian: • reakcije na mjestu primjene injekcije koje se javljaju na mjestu prethodne reakcije
English: Docetaxel is metabolised by CYP3A4 and prednisone is known to induce CYP3A4.
Croatian: Docetaksel se metabolizira s pomoću CYP3A4 dok je poznato da prednizon inducira CYP3A4.
English: Given the fact that docetaxel every week presented a slightly better safety profile than docetaxel every 3 weeks, it is possible that certain patients may benefit from docetaxel every week.
Croatian: Zbog činjenice da je docetaksel primijenjen svaki tjedan pokazao bolji profil sigurnosti primjene u odnosu na docetaksel primijenjen svaka tri tjedna, moguće je da određeni bolesnici mogu imati koristi od primanja docetaksela svaki tjedan.
English: What you need to know before you use Docetaxel Accord
Croatian: Što morate znati prije nego počnete primjenjivati Docetaxel Accord
English: From a microbiological point of view, dilution must take place in controlled and aseptic conditions.
Croatian: S mikrobiološkog stajališta, razrjeđivanje se mora odvijati u kontroliranim i aseptičkim uvjetima.
English: In vitro studies have shown that the metabolism of docetaxel may be modified by the concomitant administration of compounds which induce, inhibit or are metabolised by (and thus may inhibit the enzyme competitively) cytochrome P450-3A such as ciclosporine, ketoconazole, erythromycin.
Croatian: In vitro ispitivanja pokazala su da metabolizam docetaksela može promijeniti istodobna primjena tvari koji induciraju, inhibiraju ili se metaboliziraju (i tako kompetitivno mogu inhibirati enzim) pomoću citokroma P450-3A, kao što su ciklosporin, ketokonazol i eritromicin.
English: Patients with impaired vision should undergo a prompt and complete ophthalmologic examination.
Croatian: Bolesnici s oštećenim vidom trebaju se bez odlaganja podvrći kompletnom oftamološkom pregledu.
English: If not used immediately, in-use storage times and conditions are the responsibility of the user.
Croatian: Ako se ne upotrijebi odmah, vrijeme i uvjeti čuvanja lijeka u primjeni su odgovornost korisnika.
English: Between infusions of docetaxel the following may occur, and the frequency may vary with the combinations of medicines that are received
Croatian: Između infuzija docetaksela mogu se pojaviti sljedeće nuspojave, a učestalost može varirati ovisno o kombinacijama lijekova koje ste primili:
English: In the case of severe neutropenia (< 500 cells/mm3 for seven days or more) during a course of docetaxel therapy, a reduction in dose for subsequent courses of therapy or the use of appropriate symptomatic measures are recommended (see section 4.2).
Croatian: U slučajevima teške neutropenije ( 500 stanica/mm3 u trajanju od sedam dana ili dulje) za vrijeme liječenja docetakselom, preporuča se smanjenje doze u sljedećim ciklusima liječenja ili primjena odgovarajućih simptomatskih mjera (vidjeti dio 4.2).
English: A minority of patients were tested using fluorescence in-situ hybridization (FISH).
Croatian: Manji broj bolesnika testiran je primjenom fluorescencijske in situ hibridizacije (engl. fluorescence in-situ hybridization, FISH).
English: • blurred vision due to swelling of the retina within the eye (cystoid macular oedema)
Croatian: • zamagljen vid uzrokovan oticanjem mrežnice oka (cistoidni edem makule)
English: If the vials are stored under refrigeration, allow the required number of boxes of Docetaxel Accord concentrate for solution for infusion to stand below 25°C for 5 minutes before use.
Croatian: Ako su bočice pohranjene u hladnjaku, izvadite potreban broj kutija Docetaxel Accord koncentrata za otopinu za infuziju iz hladnjaka i ostavite ih prije primjene na temperaturi ispod 25 oC tijekom 5 minuta.
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the label of the vial after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na vanjskom pakiranju i naljepnici bočice iza oznake Rok valjanosti na kutiji i iza oznake EXP na naljepnici
English: If crystals appear, the solution must no longer be used and shall be discarded.
Croatian: Ako se kristali pojave, otopina se više ne smije se koristiti, te ju je potrebno baciti.
English: Each box contains one vial.
Croatian: Jedno pakiranje sadrži jednu bočicu.
English: • Overall response rate (ORR) was significantly higher in the AT arm versus AC arm, p = 0.009.
Croatian: • Stopa ukupnog terapijskog odgovora (engl. overall response rate, ORR) bila je značajno veća u AT skupini naspram AC skupine, p=0,009.
English: What Docetaxel Accord contains - The active substance is docetaxel.
Croatian: Što Docetaxel Accord sadrži - Djelatna tvar je docetaksel.
English: Mean values for total body clearance and steady-state volume of distribution were 21 l/h/m2 and 113 l, respectively.
Croatian: Srednje vrijednosti ukupnog klirensa i volumena distribucije u stanju dinamičke ravnoteže bile su 21 l/h/m2 odnosno 113
English: Infections and infestations Infections (G3/4: 5.7%; including sepsis and pneumonia, fatal in 1.7%)
Croatian: Infekcije i infestacije infekcije (G3/4: 5,7%; uključujući sepsu i pneumoniju, fatalno u 1,7% slučajeva)
English: Interruption of docetaxel therapy is recommended until diagnosis is available.
Croatian: Preporučuje se privremeno prekinuti liječenje docetakselom dok se ne postavi dijagnoza.
English: There was less use of morphinic analgesic (p < 0.01), non-morphinic analgesics (p < 0.01), other disease-related medicinal products (p = 0.06) and radiotherapy (p < 0.01) in patients treated with docetaxel at 75 mg/m2 compared to those with BSC.
Croatian: Manje su se davali morfinski analgetici (p<0,01), nemorfinski analgetici (p<0,01), ostali lijekovi povezani s bolesti (p=0,06) i radioterapija (p<0,01) bolesnicima koji su se liječili docetakselom 75 mg/m2 nego onima iz skupine BSC.
English: • Mitoxantrone 12 mg/m2 every 3 weeks for 10 cycles.
Croatian: • Mitoksantron 12 mg/m2 svaka tri tjedna tijekom 10 ciklusa.
English: For example, a dose of 140 mg docetaxel would require 7 ml docetaxel concentrate for solution.
Croatian: Primjerice, za dozu od 140 mg docetaksela bilo bi potrebno 7 ml docetaksel koncentrata za otopinu.
English: The median TTP was 37.3 weeks (95% CI: 33.4 - 42.1) in AT arm and 31.9 weeks (95% CI: 27.4-36.0) in AC arm.
Croatian: Medijan TTP bio je 37,3 tjedna (95% CI: 33,4-42,1) u AT skupini i 31,9 tjedna (95% CI: 27,4-36,0) u AC skupini.
English: Docetaxel Accord must NOT be administered if you are pregnant unless clearly indicated by your doctor.
Croatian: Docetaxel Accord NE SMIJETE primati ako ste trudni, osim ako to liječnik nije izričito propisao.
English: • ventricular arrhythmia or ventricular tachycardia (manifested as irregular and/or rapid heartbeat,
Croatian: • ventrikularna aritmija ili ventrikularna tahikardija (koja se manifestira kao nepravilni i/ili ubrzani otkucaji srca, teški nedostatak zraka, omaglica i/ili nesvjestica).
English: In this study, 358 patients with inoperable locally advanced SCCHN, and WHO perfomance status 0 or 1, were randomised to one of two treatment arms.
Croatian: U ovoj je studiji 358 bolesnika s inoperabilnim, lokalno uznapredovalim SCCHN, WHO izvedbenog statusa 0 ili 1, bilo randomizirano u jednu od dvije liječene skupine.
English: Inflammation of the lungs can also develop when docetaxel therapy is used with radiotherapy)
Croatian: Upala pluća se također može javiti kad se liječenje docetakselom primjenjuje s radioterapijom)
English: Pack size:
Croatian: Pakiranje:
English: mostly associated with dehydration, vomiting and pneumonia.
Croatian: Prijavljeni su slučajevi hiponatrijemije, većinom povezani s dehidracijom, povraćanjem i pneumonijom.
English: Patients who experience febrile neutropenia and/or neutropenic infection should have their docetaxel dose reduced to 60 mg/m2 in all subsequent cycles (see sections 4.4 and 4.8).
Croatian: Bolesnicima u kojih se pojavi febrilna neutropenija i/ili neutropenijska infekcija, u svim sljedećim ciklusima treba smanjiti dozu docetaksela na 60 mg/m2 (vidjeti dio 4.4 i 4.8).
English: • Aseptically withdraw the required amount of concentrate for solution for infusion with a calibrated syringe fitted with a 21G needle.
Croatian: • Aseptički izvucite potreban volumen koncentrata za otopinu za infuziju koristeći graduiranu štrcaljku s pričvršćenom iglom od 21G.
English: Exploratory subgroup analyses for disease-free survival for patients who meet the 2009 St. Gallen chemotherapy criteria - (ITT population) were performed and presented here below:
Croatian: Provedene su eksploracijske analize preživljenja bez znakova bolesti u podskupini bolesnika koji zadovoljavaju kriterije za kemoterapiju po kriterijima iz St.Gallena, 2009. (populacija s namjerom liječenja [ITT populacija]) - rezultati su prikazani u sljedećoj tablici:
English: Docetaxel was administered as a 1-hour infusion, all other medicinal products were given intravenously on day 1 every three weeks.
Croatian: Docetaksel se primjenjivao u obliku jednosatne infuzije, a svi ostali lijekovi davali su se intravenski na dan 1 svaka tri tjedna.
English: How to use Docetaxel Accord
Croatian: Kako primjenjivati Docetaxel Accord
English: Each vial is for single use and should be used immediately after opening.
Croatian: Svaka bočica namijenjena je za jednokratnu upotrebu i treba se primijeniti odmah nakon otvaranja.
English: Docetaxel Accord has been prescribed by your doctor for the treatment of breast cancer, special forms of lung cancer (non-small cell lung cancer), prostate cancer, gastric cancer or head and neck cancer: - For the treatment of advanced breast cancer, docetaxel could be administered either alone or in combination with doxorubicin, or trastuzumab, or capecitabine.
Croatian: Docetaxel Accord Vam je propisao liječnik za liječenje karcinoma dojke, posebnih oblika karcinoma pluća (karcinom nemalih stanica pluća), karcinoma prostate, karcinoma želuca ili karcinoma glave i vrata: - Za liječenje uznapredovalog karcinoma dojke, docetaksel se primjenjuje sam ili u kombinaciji s doksorubicinom, trastuzumabom ili kapecitabinom.
English: TAC (n=539)
Croatian: (n=539)
English: This is because Docetaxel Accord or the other medicine may not work as well as expected and you may be more likely to get a side effect.
Croatian: Naime, može se dogoditi da u tom slučaju Docetaxel Accord ili neki drugi lijek neće djelovati prema očekivanju te da postoji veća vjerojatnost pojave nuspojava.
English: Eye disorders Very rare cases of transient visual disturbances (flashes, flashing lights, scotomata) typically occurring during infusion of the medicinal product and in association with hypersensitivity reactions have been reported.
Croatian: Vrlo su rijetko zabilježeni prolazni poremećaji vida (bljeskovi, svjetlucanja, skotomi) koji se tipično pojavljuju tijekom infuzije lijeka udruženi s reakcijama preosjetljivosti.
English: The name of this medicine is Docetaxel Accord.
Croatian: Ovaj lijek se zove Docetaxel Accord.
English: In anthracycline-failure patients, docetaxel was compared to the combination of mitomycin C and vinblastine (12 mg/m2 every 6 weeks and 6 mg/m2 every 3 weeks).
Croatian: U bolesnika koji su neuspješno liječeni antraciklinima, docetaksel se uspoređivao s kombinacijom mitomicina C i vinblastina (12 mg/m2 svakih 6 tjedana i 6 mg/m2 svaka tri tjedna).
English: In both arms, after the last cycle of chemotherapy, patients with ER+ and/or PgR+ tumours received tamoxifen 20 mg once a day for up to 5 years.
Croatian: U obje skupine, nakon poslijednjeg ciklusa kemoterapije, bolesnici sa ER+ i/ili PgR+ tumorima, primali su tamoksifen 20 mg jednom dnevno u razdoblju do 5 godina.
English: • As with all parenteral products, infusion solution should be visually inspected prior to use, solutions containing a precipitate should be discarded.
Croatian: • Kao što je slučaj sa svim parenterainim pripravcima, infuzijsku otopinu je potrebno vizualno provjeriti prije primjene, a otopine koje sadrže precipitat ne smiju se koristiti.
English: • From a microbiological point of view, dilution must take place in controlled and aseptic conditions and the infusion solution should be used immediately.
Croatian: • S mikrobiološkog stajališta, razrijeđivanje se mora odvijati u kontroliranim i aseptičkim uvjetima, a infuzijsku otopinu je potrebno upotrijebiti odmah.