FrancophonIA/ELRC3.0 huggingface dataset:
English: Due to the missing or defective iduronate-2-sulfatase enzyme in patients with Hunter syndrome, glycosaminoglycans progressively accumulate in the cells, leading to cellular engorgement, organomegaly, tissue destruction, and organ system dysfunction.
Slovenian: Zaradi popolnega ali delnega pomanjkanja encima iduronat-2-sulfataze pri bolnikih s Hunterjevim sindromom se glikozaminoglikani progresivno kopičijo v celicah, kar povzroča povečanje celic, organomegalijo, razkroj tkiv in okvaro delovanja organskih sistemov.
English: For instructions for use, see section 6.6.
Slovenian: Za navodila za uporabo glejte poglavje 6.6.
English: Special care should be taken when administering an infusion in patients with severe underlying airway disease.
Slovenian: Posebno je treba biti pozoren pri infundiranju pri bolnikih, ki imajo hudo bolezen dihalnih poti.
English: Please consult your doctor for additional information.
Slovenian: Dodatne informacije lahko dobite pri zdravniku.
English: Of these 6 (40%) had normalised LVM by the end of the study.
Slovenian: Pri šestih bolnikih med njimi (40 %) se je do konca študije vrednost LVM povrnila na normalno vrednost.
English: If you suffer from Hunter syndrome, a carbohydrate called glycosaminoglycan which is normally broken down by your body, is not broken down and slowly accumulates in various organs in your body.
Slovenian: Če imate Hunterjev sindrom, se ogljikov hidrat, imenovan glikozaminoglikan, ki se sicer razgrajuje v telesu, ne razgrajuje in se počasi kopiči v različnih celicah v telesu.
English: This treatment should be supervised by a physician or other healthcare professional experienced in the management of patients with MPS II disease or other inherited metabolic disorders.
Slovenian: Zdravljenje mora nadzorovati zdravnik ali drug zdravstveni delavec z izkušnjami pri obravnavanju bolnikov z MPS II ali drugimi dednimi presnovnimi boleznimi.
English: The decreases in mean liver volume were seen regardless of age, disease severity, IgG antibody status or neutralising antibody status.
Slovenian: Zmanjšanje srednje prostornine jeter se je pojavilo ne glede na starost, resnost bolezni, stanje protiteles IgG ali stanje nevtralizirajočih protiteles.
English: Severe or potentially life-threatening hypersensitivity is a contraindication to rechallenge, if hypersensitivity is not controllable (see section 4.3).
Slovenian: Huda ali potencialno smrtno nevarna preobčutljivost je kontraindikacija za ponovno zdravljenje, če preobčutljivosti ni mogoče nadzorovati (glejte poglavje 4.3).
English: • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Slovenian: Posodobljen RMP je treba predložiti: ▪ na zahtevo Evropske agencije za zdravila; ▪ ob vsakršni spremembi sistema za obvladovanje tveganj, zlasti kadar je tovrstna sprememba posledica prejema novih informacij, ki lahko privedejo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
English: • Pain in the joints
Slovenian: • bolečina v sklepih
English: Mannose-6-phosphate (M6P) residues on the oligosaccharide chains allow specific binding of the enzyme to the M6P receptors on the cell surface, leading to cellular internalization of the enzyme, targeting to intracellular lysosomes and subsequent catabolism of accumulated GAG.
Slovenian: Manoza-6-fosfatne (M6P) molekule na oligosaharidnih verigah omogočajo specifično vezavo encima na receptorje za M6P na celični površini, zaradi česar lahko encim preide v celico, kjer prispe do lizosomov in omogoči katabolizem nakopičenih GAG.
English: There is no experience with overdoses of this medicine.
Slovenian: Izkušenj s prevelikim odmerjanjem tega zdravila ni.
English: Elaprase is supplied in pack sizes of 1, 4 and 10 vials per carton.
Slovenian: Zdravilo Elaprase je na voljo v velikostih pakiranja po 1, 4 in 10 vial na škatlo.
English: No clinical data exist demonstrating a benefit on the neurological manifestations of the disorder.
Slovenian: Kliničnih podatkov o pozitivnem vplivu na nevrološke znake bolezni ni.
English: Do not use Elaprase
Slovenian: Ne uporabljajte zdravila Elaprase
English: Home infusions should be performed under the surveillance of a physician or other healthcare professional.
Slovenian: Infundiranje na domu mora nadzorovati zdravnik ali drug zdravstveni delavec.
English: The patients in the weekly treatment group experienced a clinically significant 15% mean improvement in FEV1 at the end of the study.
Slovenian: Pri bolnikih, ki so zdravljenje prejemali enkrat tedensko, je bilo klinično pomembno izboljšanje srednje vrednosti FEV1 na koncu študije 15-odstotno.
English: • Abdominal pain, nausea, vomiting, frequent and/or loose stools
Slovenian: • bolečine v trebuhu, slabost, bruhanje, pogosto in/ali redko blato
English: Across 4 clinical studies (TKT008, TKT018, TKT024 and TKT024EXT), 53/107 patients (50%) developed anti-idursulfase IgG antibodies at some point.
Slovenian: V štirih študijah (TKT008, TKT018, TKT024 in TKT024EXT) so se pri 53/107 bolnikov (50 %) razvila protitelesa IgG proti idursulfazi.
English: Degradation of idursulfase is achieved by generally well understood protein hydrolysis mechanisms to produce small peptides and amino acids, consequently renal and liver function impairment is not expected to affect the pharmacokinetics of idursulfase.
Slovenian: Po razkroju idursulfaze, ki poteka po splošno dobro znanih mehanizmih hidrolize beljakovin, nastanejo majhni peptidi in aminokisline, zato se ne pričakuje, da bi okvara delovanja ledvic ali jeter vplivala na farmakokinetiko idursulfaze.
English: Analyses of genotypes of patients in study HGT-ELA-038
Slovenian: Analize genotipov bolnikov v študiji HGT-ELA-038
English: Urine GAG levels were normalized below the upper limit of normal (defined as 126.6 µg GAG/mg creatinine) in 50% of the patients receiving weekly treatment.
Slovenian: Ravni GAG v urinu so se pri 50 % bolnikov, ki so prejemali tedensko zdravljenje, normalizirale pod zgornjo mejo normalne vrednosti (opredeljene kot 126,6 µg GAG/mg kreatinina).
English: The most common were infusion-related reactions, 202 of which were reported in 22 out of 32 patients following administration of a total of 1580 infusions.
Slovenian: Med njimi so o 202 učinkih poročali pri 22 od 32 bolnikov, po infundiranju skupno 1580 infuzij.
English: In a 52-week, randomized, double-blind, placebo-controlled clinical study, 96 patients between the ages of 5 and 31 years received Elaprase 0.5 mg/kg every week (n=32) or 0.5 mg/kg every other week (n=32), or placebo (n=32).
Slovenian: V 52-tedenski, randomizirani, dvojno slepi, s placebom nadzorovani klinični študiji je 96 bolnikov, starih od 5 do 31 let, prejemalo zdravilo Elaprase, in sicer 0,5 mg/kg vsak teden (n = 32), 0,5 mg/kg vsak drugi teden (n = 32) ali placebo (n = 32).
English: Study TKT024
Slovenian: Študija TKT024
English: * idursulfase is produced by recombinant DNA technology in a continuous human cell line.
Slovenian: * Idursulfaza se izdeluje v neprekinjeni humani celični liniji s tehnologijo rekombinantne DNA.
English: It is supplied in a glass vial as a clear to slightly opalescent, colourless solution.
Slovenian: Na voljo je v stekleni viali v obliki prozorne do rahlo opalescentne brezbarvne raztopine.
English: Iduronate-2-sulfatase functions to catabolize the glycosaminoglycans (GAG) dermatan sulfate and heparan sulfate by cleavage of oligosaccharide-linked sulfate moieties.
Slovenian: Iduronat-2-sulfataza katabolizira glikozaminoglikanove (GAG) dermatansulfate in heparanove sulfate s cepljenjem oligosaharidno-povezanih sulfatnih delov.
English: In a post-hoc analysis of immunogenicity in studies TKT024 and TKT024EXT (see section 4.8), patients were shown to have either the mis-sense mutation or the frameshift / nonsense mutation.
Slovenian: V post hoc analizi imunogenosti na podlagi študij TKT024 in TKT024EXT (glejte poglavje 4.8) so pokazali, da imajo bolniki drugačnosmiselno mutacijo ali mutacijo s premikom bralnega okvirja/nesmiselno mutacijo.
English: • Flushing (redness)
Slovenian: • zardevanje (rdečica)
English: If you are treated with Elaprase you may experience side effects during or following an infusion (see section 4 Possible side effects).
Slovenian: Če se zdravite z zdravilom Elaprase, boste morda med infundiranjem ali po njem imeli neželene učinke (glejte poglavje 4 Možni neželeni učinki).
English: 52 weeks of treatment 0.5 mg/kg weekly Marginally weighted (OM) mean (SE)
Slovenian: 52 tednov zdravljenja 0,5 mg/kg/teden Marginalno opazovana meja (OM) srednja vrednost (SN)
English: Patients who have experienced anaphylactoid/anaphylactic reactions should be treated with caution when readministering idursulfase, appropriately trained personnel and equipment for emergency resuscitation (including epinephrine) should be available during infusions.
Slovenian: Pri bolnikih, ki so že imeli anafilaktoidne/anafilaktične reakcije, je pri ponovni uporabi idursulfaze potrebna previdnost; med infuzijo morata biti na voljo ustrezno usposobljeno osebje in oprema za nujno oživljanje (vključno z adrenalinom).
English: This was an open-label, multicenter, single-arm study of idursulfase infusions in male Hunter syndrome patients between the age of 16 months and 7.5 years.
Slovenian: To je bila odprta, multicentrična študija z enim krakom, v kateri so ocenjevali infuzijo idursulfaze pri bolnikih moškega spola s Hunterjevim sindromom, starih od 16 mesecev do 7,5 leta.
English: Do not use this medicine if you notice that there is discolouration or presence of foreign particles.
Slovenian: Ne uporabljajte tega zdravila, če opazite, da je raztopina spremenila barvo ali so v njej delci.
English: It is recommended to deliver the total volume of infusion using a 0.2 µm in line filter.
Slovenian: Priporoča se aplikacija skupnega volumna infuzije skozi 0,2 µm linijski filter.
English: Statistically significant increases from treatment baseline in absolute FVC volume were seen at most visits for all treatment groups combined and for each of the prior TKT024 treatment groups.
Slovenian: Statistično pomembna povečanja od izhodiščnih vrednosti absolutne prostornine FVK pri zdravljenju so opazili pri večini obiskov v vseh skupinah, vključno s tistimi, ki so se predhodno zdravile v študiji TKT024.
English: Related reactions in the placebo group were similar in nature and severity to those in the treated group.
Slovenian: V skupini, ki je prejemala placebo, sta bili narava in pogostnost učinkov podobni kot v skupini, ki je prejemala zdravilo.
English: One patient was unclassified / unclassifiable.
Slovenian: Enega bolnika ni bilo mogoče razvrstiti v nobeno skupino.
English: Patients with complete deletion/large rearrangement genotype have a higher probability of developing infusion related adverse events (see section 4.4).
Slovenian: Pri bolnikih z genotipom s popolno delecijo/obsežno preureditvijo je večja verjetnost za pojav neželenih učinkov, povezanih z infuzijo (glejte poglavje 4.4).
English: Very common side effects (may affect more than 1 in 10 people) are:
Slovenian: Zelo pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 10 bolnikov) so:
English: A higher volume of distribution at steady state (Vss) was observed in the lowest weight groups.
Slovenian: V skupinah z najmanjšo telesno maso so opazili večji volumen porazdelitve v stanju dinamičnega ravnovesja (Vss).
English: Store in a refrigerator Do not freeze
Slovenian: Shranjujte v hladilniku.
English: Each vial of Elaprase is intended for single use only and contains 6 mg of idursulfase in 3 ml of solution.
Slovenian: Vsaka viala zdravila Elaprase je namenjena le enkratni uporabi in vsebuje 6 mg idursulfaze v 3 ml raztopine.
English: Elaprase should not be infused with other medicinal products in the infusion tubing.
Slovenian: Zdravilo Elaprase se ne sme infundirati z drugimi zdravili skozi isto cevko.
English: Idursulfase is a purified form of the lysosomal enzyme iduronate-2-sulfatase, produced in a human cell line providing a human glycosylation profile, which is analogous to the naturally occurring enzyme.
Slovenian: Idursulfaza je prečiščena oblika lizosomskega encima iduronat-2-sulfataze, izdelanega v humani celični liniji, ki omogoča humani profil glikozilacije, ki je analogen naravnemu encimu.
English: There is no experience with overdoses of Elaprase.
Slovenian: Izkušenj s prevelikim odmerjanjem zdravila Elaprase ni.
English: SPECIFIC OBLIGATION TO COMPLETE POSTAUTHORISATION MEASURES FOR THE MARKETING AUTHORISATION UNDER EXCEPTIONAL CIRCUMSTANCES
Slovenian: SPECIFIČNE ZAHTEVE ZA IZPOLNITEV UKREPOV PO PRIDOBITVI DOVOLJENJA ZA PROMET Z ZDRAVILOM V IZJEMNIH OKOLIŠČINAH
English: Mean cardiac LVMI remained stable over 36 months of idursulfase treatment within each TKT024 treatment group.
Slovenian: Srednji indeks leve ventrikularne mase (LVMI) je ostal stabilen v 36 mesecih zdravljenja z idursulfazo v vseh skupinah TKT024, ki so jih zdravili.
English: Elaprase contains an active substance called idursulfase which works by acting as a replacement for the enzyme that is at a low level, thereby breaking down this carbohydrate in affected cells.
Slovenian: Zdravilo Elaprase vsebuje učinkovino, imenovano idursulfaza, ki nadomesti encim, ki ga primanjkuje, in razgrajuje ta ogljikov hidrat v prizadetih celicah.
English: Patients with the complete deletion/large rearrangement genotype Paediatric patients with the complete deletion/large rearrangement genotype have a high probability of developing antibodies, including neutralizing antibodies, in response to exposure to idursulfase.
Slovenian: Bolniki z genotipom s popolno delecijo/obsežno preureditvijo Pri pediatričnih bolnikih z genotipom s popolno delecijo/obsežno preureditvijo je velika verjetnost, da bodo kot odziv na izpostavljenost idursulfazi razvili protitelesa, vključno z nevtralizirajočimi protitelesi.
English: Hunter syndrome is an X-linked disease caused by insufficient levels of the lysosomal enzyme iduronate-2-sulfatase.
Slovenian: Hunterjev sindrom je bolezen, povezana s kromosomom X, ki jo povzročajo nezadostne količine lizosomskega encima iduronat-2-sulfataze.
English: What Elaprase looks like and contents of the pack
Slovenian: Izgled zdravila Elaprase in vsebina pakiranja
English: At their final visit 21/31 patients in the TKT024 Weekly group, 24/32 in the TKT024 EOW group and 18/31 patients in the TKT024 placebo group had final normalised urine GAG levels that were below the upper limit of normal.
Slovenian: Pri zadnjem obisku je imelo 21/31 bolnikov v skupini TKT024 enkrat na teden, 24/32 bolnikov v skupini TKT024 vsak drugi teden in 18/31 bolnikov v skupini TKT024 s placebom končne normalizirane ravni GAG v urinu, ki so bile pod zgornjo mejo.
English: These events did not recur with subsequent infusions using a slower infusion rate and administration of pre-infusion medicinal products, usually low-dose steroids, antihistamine, and beta-agonist nebulisation.
Slovenian: Do teh dogodkov ni prišlo pri poznejših infundiranjih, pri katerih so zmanjšali hitrost infundiranja in uporabili predinfuzijska zdravila, ponavadi majhne odmerke steroidov, antihistaminike in nebulizator z beta-agonisti.
English: There have been post-marketing reports of anaphylactoid/anaphylactic reactions (see section 4.4).
Slovenian: Na voljo so poročila iz obdobja trženja o anafilaktoidnih/anafilaktičnih reakcijah (glejte poglavje 4.4).
English: Among patients who were originally randomised to weekly idursulfase in TKT024, mean maximum improvement in distance walked during six minutes occurred at Month 20 and mean percent predicted FVC peaked at Month 16.
Slovenian: Pri bolnikih, ki so bili v študiji TKT024 naključno razporejeni v izvirno skupino z idursulfazo enkrat na teden, se je srednje največje izboljšanje v razdalji, prehojeni v šestih minutah, pojavilo v 20. mesecu, srednji odstotek predvidene FVK pa je bil največji v 16. mesecu.
English: Fertility No effects on male fertility were seen in reproductive studies in male rats.
Slovenian: Plodnost V študijah vpliva na sposobnost razmnoževanja pri samcih podgan niso opazili vpliva na plodnost.
English: At most time points tested, patients who were from the original TKT024 weekly treatment group improved their walking distance to a greater extent that patients in the other 2 treatment groups.
Slovenian: Pri večini testiranih točk se je pri bolnikih, ki so bili v izvirni skupini TKT024, ki se je zdravila enkrat na teden, prehojena razdalja bolj podaljšala kot pri bolnikih v drugih dveh skupinah.
English: During the 53-week study, 67.9% (19 of 28) of patients had at least one blood sample that tested positive for anti-idursulfase antibodies, and 57.1% (16 of 28) tested positive for antibodies on at least three consecutive study visits.
Slovenian: V 53-tedenski študiji je imelo 67,9 % (19 od 28) bolnikov vsaj en vzorec krvi s pozitivnim rezultatom testa protiteles proti idursulfazi in 57,1 % (16 od 28) bolnikov pozitivne teste protiteles ob vsaj treh zaporednih študijskih obiskih.
English: Among all patients, statistically significant mean increases from treatment baseline (TKT024 baseline for TKT024 idursulfase patients and Week 53 baseline for TKT024 placebo patients) were seen in the distance walked 6MWT at the majority of time points tested, with significant mean and percent increases ranging from 13.7m to 41.5m (maximum at Month 20) and from 6.4% to 13.3% (maximum at Month 24) respectively.
Slovenian: Pri vseh bolnikih se je statistično pomembno srednje povečanje od izhodiščne vrednosti pri zdravljenju (izhodiščna vrednost TKT024 za bolnike z idursulfazo TKT024 in izhodiščna vrednost v 53. tednu za bolnike s placebom TKT024) v razdalji, prehojeni v šestih minutah, pokazalo pri večini testiranih točk, pri čemer so bila srednja in odstotna povečanja od 13,7 m do 41,5 m (največ v 20. mesecu) oziroma od 6,4 % do 13,3 % (največ v 24. mesecu).
English: Chemical and physical in-use stability has been demonstrated for 8 hours at 25°C.
Slovenian: Raztopina ostane kemično in fizično stabilna osem ur, če jo hranimo pri temperaturi do 25 °C.
English: Of the 25 patients with abnormally large livers at baseline in the weekly treatment group, 80% (20 patients) had reductions in liver volume to within the normal range by the end of the study.
Slovenian: Med 25 bolniki z nenormalno povečanimi jetri na začetku študije se je v skupini, ki je prejemala tedensko zdravljenje, pri 80 % (20 bolnikih) prostornina jeter do konca študije zmanjšala do obsega normalne prostornine.
English: The other ingredients are Polysorbate 20, sodium chloride, dibasic sodium phosphate, heptahydrate, monobasic sodium phosphate, monohydrate and water for injections.
Slovenian: Druge sestavine zdravila so polisorbat 20, natrijev klorid, natrijev dihidrogenfosfat heptahidrat, natrijev hidrogenfosfat monohidrat in voda za injekcije.
English: In the placebo treatment group 128 infusion-related reactions were reported in 21 out of 32 patients following administration of a total of 1612 infusions.
Slovenian: V skupini, ki je prejemala placebo, so pri 21 od 32 bolnikov poročali o 128 učinkih, povezanih z infundiranjem, po infundiranju skupno 1612 infuzij.
English: Idursulfase is secreted as a 525 amino acid glycoprotein and contains 8 N-linked glycosylation sites that are occupied by complex, hybrid, and high-mannose type oligosaccharide chains.
Slovenian: Idursulfaza se izloča kot glikoprotein, sestavljen iz 525 aminokislin in vsebuje osem z N povezanih mest glikozilacije, na katerih so kompleksne hibridne oligosaharidne verige z veliko manoze.
English: There are no data or limited amount of data from the use of idursulfase in pregnant women.
Slovenian: Podatkov o uporabi idursulfaze pri nosečnicah ni oziroma so omejeni.
English: Patients treated with idursulfase may develop infusion-related reactions (see section 4.8).
Slovenian: Pri bolnikih, ki prejemajo idursulfazo, se lahko pojavijo učinki, povezani z infundiranjem (glejte poglavje 4.8).
English: If an anaphylactoid/anaphylactic reaction occurs the infusion should be immediately suspended and appropriate treatment and observation initiated.
Slovenian: Če pride do anafilaktoidne/anafilaktične reakcije, je treba infundiranje takoj ustaviti in bolnika začeti ustrezno zdraviti ter opazovati.
English: Idursulfase is taken up by selective receptor-mediated mechanisms involving binding to mannose 6phosphate receptors.
Slovenian: Prevzem idursulfaze poteka prek mehanizmov, ki jih uravnavajo selektivni receptorji, pri katerih se zdravilo veže na receptorje za manozo-6-fosfat.
English: % Change in liver volume
Slovenian: % spremembe prostornine jeter
English: The complete deletion/ large rearrangement genotype was most commonly associated with development of high titre of antibodies and neutralising antibodies to idursulfase and was most likely to display a muted response to the medicinal product.
Slovenian: Genotip s popolno delecijo/obsežno preureditvijo je bil najpogosteje povezan z razvojem visokega titra protiteles in nevtralizirajočih protiteles proti idursulfazi in v tej skupini je bil zmanjšan odziv na zdravilo najverjetnejši.
English: Instructions for use, handling and disposal
Slovenian: Navodila za pripravo in ravnanje z zdravilom in odlaganje
English: No formal medicinal product interaction studies have been conducted with idursulfase.
Slovenian: Formalnih študij medsebojnega delovanja idursulfaze z drugimi zdravili niso izvedli.
English: • Rapid heartbeat, irregular heartbeat, bluish skin
Slovenian: • hiter srčni utrip, nereden srčni utrip, modrikasta koža
English: Animal studies have shown excretion of idursulfase in breast milk.
Slovenian: Študije na živalih so pokazale, da se idursulfaza izloča v mleko.
English: In the post-hoc immunogenicity analysis of data from TKT024/024EXT studies, 51% (32/63) patients treated with 0.5mg/kg weekly idursulfase had at least 1 blood sample that tested positive for antiidursulfase antibodies, and 37 % (23/63) tested positive for antibodies on at least 3 consecutive study visits.
Slovenian: V post hoc analizi imunogenosti na podlagi podatkov iz študij TKT024/024EXT je imelo 51 % (32/63) bolnikov, zdravljenih z 0,5 mg/kg idursulfaze na teden, vsaj 1 krvni vzorec, ki je bil pozitiven za protitelesa proti idursulfazi, 37 % (23/63) pa je bilo pozitivnih za protitelesa pri vsaj 3 zaporednih obiskih v študiji.
English: The mean and percent changes from treatment baseline were greatest in the group of patients from the TKT024 study who had received the weekly dosing, across all time points.
Slovenian: Srednje in odstotne spremembe od izhodiščnih vrednosti pri zdravljenju so bile na vseh časovnih točkah največje v skupini bolnikov iz študije TKT024, ki so odmerek prejemali enkrat na teden.
English: If you have missed an Elaprase infusion, please contact your doctor.
Slovenian: Če ste izpustili infuzijo zdravila Elaprase, se obrnite na zdravnika.
English: Patients who developed a high titre of antibodies displayed less response to idursulfase as assessed by urine output of glycosaminoglycans and by liver and spleen size.
Slovenian: Bolniki, ki so razvili visok titer protiteles, so pokazali slabši odziv na idursulfazo, kar so ocenili po izločanju glikozaminoglikanov z urinom ter po velikosti jeter in vranice.
English: Infusion-related reactions were treated or ameliorated by slowing the infusion rate, interrupting the infusion, or by administration of medicinal products, such as antihistamines, antipyretics, low-dose corticosteroids (prednisone and methylprednisolone), or beta-agonist nebulisation.
Slovenian: Učinke, povezane z infundiranjem, so zdravili ali ublažili z zmanjšanjem hitrosti infundiranja, prekinjanjem infundiranja, z uporabo zdravil, kot so antihistaminiki, antipiretiki, majhni odmerki kortikosteroidov (prednizon in metilprednizolon) ali uporabo nebulizatorja z beta-agonisti.