FrancophonIA/ELRC3.0 huggingface dataset:
English: If you experience a new attack, your doctor may consider giving you a new dose of Ilaris but not earlier than 12 weeks from the previous dose.
Slovenian: Če pride do novega napada, bo zdravnik razmislil o možnosti, da vam da nov odmerek zdravila Ilaris, vendar ne prej kot 12 tednov po predhodnem odmerku.
English: This is clinically relevant for CYP450 substrates with a narrow therapeutic index where the dose is individually adjusted.
Slovenian: To je klinično pomembno pri substratih CYP450 z ozkim terapevtskim oknom, katerih odmerjanje je treba prilagajati posameznemu bolniku.
English: No differences in safety or efficacy were observed in patients under the age of 2 years compared with patients aged 2 years and above.
Slovenian: Pri tem niso opažali nobenih razlik glede varnosti in učinkovitosti pri bolnikih, ki so bili stari manj kot 2 leti; v primerjavi z bolniki, ki so bili stari 2 leti ali več.
English: If the solution has a distinctly brown discolouration it should not be used.
Slovenian: Če ima raztopina izrazito rjavo barvo, je ne smete uporabiti.
English: Patients > 28 days but < 2 years of age were allowed to enter the study directly into an open-arm of Part II as nonrandomised patients (and were excluded from the primary efficacy analysis).
Slovenian: Bolnike, ki so bili stari > 28 dni, a manj kot 2 leti, so vključili v študijo neposredno v 2. obdobje, in sicer v skupino z odprtim zdravljenjem kot nerandomizirane bolnike (njihovi podatki niso bili vključeni v primarno analizo učinkovitosti).
English: Essential preparation
Slovenian: Obvezna predpriprava
English: There is a limited amount of data from the use of canakinumab in pregnant women.
Slovenian: Obseg podatkov o uporabi kanakinumaba pri nosečnicah je omejen.
English: The efficacy of canakinumab for the treatment of active SJIA was assessed in two pivotal studies (G2305 and G2301).
Slovenian: Učinkovitost kanakinumaba pri zdravljenju aktivnega SJIA so ocenjevali v dveh ključnih študijah (G2305 in G2301).
English: The primary objective was the proportion of patients at day 15 who achieved a minimum 30% improvement in the paediatric American College of Rheumatology (ACR) response criterion adapted to include absence of fever.
Slovenian: Primarni cilj opazovanja v študiji je bil delež bolnikov, pri katerih je 15. dan v študiji prišlo do najmanj 30-odstotnega izboljšanja po pediatričnih kriterijih Ameriškega združenja za revmatologijo (ACRAmerican College of Rheumatology) ki so jih priredili tako, da so vključevali še odsotnost zvišane telesne temperature.
English: Ilaris has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo Ilaris ima blag vpliv na sposobnost vožnje in upravljanja strojev.
English: Gouty arthritis is caused by the formation of urate crystals.
Slovenian: Urični artritis povzroča nastajanje uratnih kristalov.
English: Packs containing 1 vial.
Slovenian: Pakiranja vsebujejo 1 vialo.
English: Turn the vial and syringe upside down and bring to eye level.
Slovenian: Obrnite vialo in brizgo na glavo in ju dvignite do višine svojih oči.
English: Formal studies of the potential effect of canakinumab on human fertility have not been conducted.
Slovenian: Formalnih študij možnega vpliva kanakinumaba na plodnost pri ljudeh niso izvajali.
English: The apparent volume of distribution (V/F) was 4.96 l at body weight of 55 kg.
Slovenian: Navidezni volumen porazdelitve (V/F) je pri telesni masi 55 kg znašal 4,96 l.
English: Gouty arthritis: If you have a gouty arthritis attack, you will be given a single dose of Ilaris.
Slovenian: Urični artritis: Če imate napad uričnega artritisa, boste prejeli en sam odmerek zdravila Ilaris.
English: If you have gouty arthritis, your treatment will be overseen by a doctor with specialist training.
Slovenian: Če imate urični artritis, bo vaše zdravljenje nadzoroval zdravnik specialist, ki bo za to posebej usposobljen.
English: At week 12, the adapted paediatric ACR30, 50, 70, 90 and 100 responses were: 70%, 69%, 61%, 49% and 30%, respectively and 28% of patients had inactive disease (N=178).
Slovenian: Po 12 tednih zdravljenja so odzivi po prirejenih pediatričnih kriterijih odziva ACR30, 50, 70, 90 in 100 znašali: 70 %, 69 %, 61 %, 49 % oziroma 30 %, pri 28 % bolnikov pa je bila bolezen neaktivna (N=178).
English: This product information has been updated to include the results of studies with Ilaris in the paediatric population.
Slovenian: Te informacije o zdravilu so že dopolnjene z rezultati študij zdravila Ilaris pri pediatrični populaciji.
English: The primary objective was to assess the proportion of patients who were free of relapse at week 24, including those patients whose dose was increased.
Slovenian: Primarni cilj študije je bil oceniti delež bolnikov, pri katerih v 24 tednih ni prišlo do ponovitve bolezni, pri čemer so upoštevali tudi tiste bolnike, ki so jim odmerke zvišali.
English: The results of a study in healthy adult subjects demonstrated that a single dose of Ilaris 300 mg did not affect the induction and persistence of antibody responses after vaccination with influenza or glycosylated protein based meningococcus vaccines.
Slovenian: Rezultati študije pri zdravih odraslih so pokazali, da enkratni odmerek 300 mg zdravila Ilaris ni vplival na indukcijo in trajnost protitelesnih odzivov po cepljenju s cepivom proti gripi oziroma s cepivom proti meningokoku, ki vsebuje glikozilirane proteine.
English: Over 85% of patients had comorbidity, including hypertension (60%), diabetes (15%), ischaemic heart disease (12%), and stage ≥ 3 chronic kidney disease (25%).
Slovenian: Več kot 85 % bolnikov je imelo sočasno še katero od drugih bolezni, med drugim hipertenzijo (60 %), sladkorno bolezen (15 %), ishemično bolezen srca (12 %) in kronično ledvično bolezen 3. ali višje stopnje (25 %).
English: If possible, avoid touching the rubber stopper with your fingers.
Slovenian: Če se le da, se s prstom ne dotikajte gumijastega zamaška.
English: Approximately one-third of the patients enrolled (76 [33.8%] in the canakinumab group and 84 [36.7%] in the triamcinolone acetonide group) had documented inability (intolerance, contraindication or lack of response) to use both NSAIDs and colchicine.
Slovenian: Približno ena tretjina vključenih bolnikov (76 [33,8 %] v skupini s kanakinumabom in 84 [36,7 %] v skupini s triamcinolon acetonidom) je imela dokumentirano nezmožnost (neprenašanje, kontraindikacije ali nezadosten učinek) uporabe tako nesteroidnih protivnetnih zdravil kot kolhicina.
English: From a microbiological point of view, the product should be used immediately after first opening.
Slovenian: S stališča mikrobiološke varnosti je treba zdravilo uporabiti takoj po odprtju.
English: All patients who received non-live, standard of care childhood vaccinations (N=7) developed protective antibody levels.
Slovenian: Pri vseh bolnikih, ki so prejeli neživa cepiva po standardnem programu cepljenja v otroški dobi (N=7), se je razvila zaščitna raven protiteles.
English: Pharmacotherapeutic group: Immunosuppressants, interleukin inhibitors, ATC code: L04AC08
Slovenian: Farmakoterapevtska skupina: Zdravila za zaviranje imunske odzivnosti, zaviralci interlevkinov, oznaka ATC: L04AC08
English: * human monoclonal antibody produced in mouse myeloma Sp2/0 cells by recombinant DNA technology
Slovenian: * humano monoklonsko protitelo, pridobljeno iz celic mišjega mieloma Sp2/0 s tehnologijo rekombinantne DNA
English: What Ilaris is and what it is used for
Slovenian: Kaj je zdravilo Ilaris in za kaj ga uporabljamo
English: Patients who do not respond to initial treatment should not be re-treated with canakinumab.
Slovenian: Bolniki, ki se ne odzovejo na začetno zdravljenje, kanakinumaba ne smejo ponovno prejeti.
English: The co-primary endpoints were: (i) gouty arthritis pain intensity (visual analogue scale, VAS) at 72 hours post-dose, and (ii) time to first new gouty arthritis attack.
Slovenian: Enakovredna primarna cilja opazovanja sta bila: (1) intenzivnost bolečine pri uričnem artritisu (ocena na vizualni analogni lestvici - VAS) 72 ur po odmerjanju in (2) čas do prvega novega napada uričnega artritisa.
English: If you received canakinumab while you were pregnant, it is important that you inform the baby's doctor or nurse before any vaccinations are given to your baby.
Slovenian: Če ste v času nosečnosti prejemali kanakinumab, je pomembno, da o tem obvestite otrokovega zdravnika ali medicinsko sestro, preden vaš otrok prejme katerokoli cepivo.
English: 9/l) and leukopenia have been observed with medicinal products that inhibit IL-1, including canakinumab.
Slovenian: 9/l) in levkopenijo so pogosto opažali pri uporabi zdravil, ki zavirajo IL-1, med katere sodi tudi kanakinumab.
English: The distribution volume (Vss) of canakinumab varied according to body weight.
Slovenian: Volumen porazdelitve (Vss) kanakinumaba je odvisen od telesne mase.
English: A total of 324 SJIA patients aged 2 to < 20 years have received Ilaris in interventional clinical trials, including 293 patients aged 2 to < 16 years old, 21 patients aged 16 to < 18 years old and 10 patients aged 18 to < 20 years old.
Slovenian: Skupno je v intervencijskih kliničnih študijah prejemalo zdravilo Ilaris 324 bolnikov s SJIA, ki so bili stari od 2 do <20 let, vključno z 293 bolniki, ki so bili stari od 2 do <16 let, 21 bolniki, ki so bili stari od 16 do <18 let, in 10 bolniki, ki so bili stari od 18 do <20 let.
English: Let the vial stand unopened for 10 minutes to bring the contents to room temperature.
Slovenian: Vialo pustite zaprto stati 10 minut, da se njena vsebina ogreje na sobno temperaturo.
English: If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C - 8°C.
Slovenian: Če zdravila ne uporabi takoj, je uporabnik sam odgovoren za čas in pogoje shranjevanja pred uporabo, ki naj praviloma ne presegajo 24 ur pri 2 °C - 8 °C.
English: In the Phase I/II study, treatment with canakinumab had a rapid onset of action, with disappearance or clinically significant improvement of symptoms within one day after dosing.
Slovenian: V študiji faze I/II je zdravljenje s kanakinumabom začelo hitro delovati, tako da so simptomi izzveneli ali se klinično pomembno izboljšali v enem dnevu po odmerjanju.
English: It is not known whether Ilaris passes into human milk.
Slovenian: Ni znano, ali zdravilo Ilaris pri človeku prehaja v materino mleko.
English: CAPS in adults and children  4 years of age  15 kg
Slovenian: CAPS pri odraslih in otrocih, starih  4 leta in z  15 kg
English: However, the risk of severe hypersensitivity reactions, which is not uncommon for injectable proteins, cannot be excluded (see section 4.3).
Slovenian: Kljub temu pa tveganja za hude preobčutljivostne reakcije ni mogoče izključiti, saj pri proteinih, ki so primerni za injiciranje, te niso redek pojav (glejte poglavje 4.3).
English: The majority of paediatric patients achieved improvement in clinical symptoms and objective markers of inflammation (e.g. SAA and CRP).
Slovenian: Pri večini pediatričnih bolnikov je prišlo do izboljšanja kliničnih simptomov in vrednosti objektivnih označevalcev vnetja (na primer SAA in CRP).
English: Of the total 128 patients who entered Part I taking corticosteroids, 92 attempted corticosteroid tapering.
Slovenian: Izmed skupno 128 bolnikov, ki so ob vstopu v 1. obdobje jemali kortikosteroide, jih je 92 poskušalo postopno ukiniti zdravljenje z njimi.
English: Ilaris is intended for subcutaneous use.
Slovenian: Zdravilo Ilaris je namenjeno podkožni uporabi.
English: If you need another treatment with Ilaris, and got relief from the last dose, you must wait at least 12 weeks before the next dose.
Slovenian: Če ponovno potrebujete zdravljenje z zdravilom Ilaris in vam je predhodni odmerek ustrezno pomagal, morate do naslednjega odmerka počakati najmanj 12 tednov.
English: An increased dose was administered more frequently to patients aged 2 to < 4 years and to patients with NOMID/CINCA symptoms compared with FCAS or MWS.
Slovenian: Odmerke so pogosteje zvišali bolnikom, ki so bili stari od 2 do < 4 leta, in bolnikom s sindromom NOMID/CINCA v primerjavi z bolniki, ki so imeli sindrom FCAS ali MWS.
English: For instructions on reconstitution of the medicinal product before administration, see section 6.6.
Slovenian: Navodila za rekonstrukcijo zdravila pred uporabo so v poglavju 6.6.
English: Now, gently turn the vial upside down and back again ten times, again taking care not to touch the rubber stopper.
Slovenian: Zatem vialo desetkrat nežno obrnite na glavo in spet nazaj in pazite, da se pri tem ne dotaknete gumijastega zamaška.
English: These crystals cause excessive production of IL-1 beta, which in turn can lead to sudden, severe pain, redness, warmth and swelling in a joint (known as a gouty arthritis attack).
Slovenian: Ti kristali povzročajo prekomerno nastajanje snovi IL-1 beta, ta pa lahko povzroči nenadne hude bolečine, rdečino, toploto in otekanje sklepov (kar poznamo kot napad uričnega artritisa).
English: Exposure parameters (such as AUC and Cmax) increased in proportion to dose over the dose range of 0.30 to 10.0 mg/kg given as intravenous infusion or from 150 to 600 mg as subcutaneous injection.
Slovenian: Parametri izpostavljenosti zdravilu (kot sta AUC in Cmax) se zvišujejo sorazmerno z odmerkom v obsegu odmerkov od 0,30 do 10,0 mg/kg pri intravenskem infundiranju oziroma v obsegu odmerkov od 150 do 600 mg pri subkutanem injiciranju zdravila.
English: Your doctor will discuss with you the potential risks of taking Ilaris during pregnancy.
Slovenian: Zdravnik vam bo razložil možna tveganja pri zdravljenju z zdravilom Ilaris med nosečnostjo.
English: The apparent clearance (CL/F) of canakinumab increases with body weight.
Slovenian: Navidezni očistek (CL/F) kanakinumaba se povečuje s telesno maso.
English: Uric acid increases were not observed in clinical trials in non-gouty arthritis populations (see section 5.1).
Slovenian: Zvišanja koncentracije sečne kisline niso opažali v kliničnih preskušanjih pri populacijah brez uričnega artritisa (glejte poglavje 5.1).
English: What you need to know before you use Ilaris
Slovenian: Kaj morate vedeti, preden boste uporabili zdravilo Ilaris
English: The causal relationship of canakinumab to these events cannot be excluded.
Slovenian: Vzročne povezave med temi dogodki in kanakinumabom ne moremo izključiti.
English: Find a clean place in which to prepare and administer the injection.
Slovenian: Poiščite čist prostor, v katerem boste pripravljali in uporabili injekcijo.
English: Serum amyloid A ≤ 10 mg/l
Slovenian: serumski amiloid A ≤ 10 mg/l
English: The doctor or nurse will demonstrate how to administer Ilaris injections.
Slovenian: Zdravnik ali medicinska sestra vam bosta pokazala, kako je treba injicirati zdravilo Ilaris.
English: Physicians should exercise caution when administering canakinumab to patients with infections, a history of recurring infections, or underlying conditions which may predispose them to infections.
Slovenian: Zdravniki morajo biti previdni, kadar dajejo kanakinumab bolnikom z okužbo, z anamnezo ponavljajočih se okužb ali z boleznijo, zaradi katere so bolniki nagnjeni k okužbam.
English: Clinical experience with dosing at intervals of less than 4 weeks or at doses above 600 mg or 8 mg/kg is limited.
Slovenian: Kliničnih izkušenj z odmerjanjem v intervalih, ki so krajši od 4 tednov, in z uporabo odmerkov nad 600 mg oziroma 8 mg/kg je malo.
English: Canakinumab N=43
Slovenian: kanakinumab N=43
English: Secondary endpoints (disease and inflammatory markers)
Slovenian: Sekundarni cilji študije (označevalci bolezni in vnetja)
English: Only patients with confirmed NLRP3 mutation were included in the pivotal study.
Slovenian: V ključno študijo so bili vključeni samo bolniki s potrjeno mutacijo NLRP3.
English: Make sure 1.0 ml of water is in the syringe, then take the needle out of the vial.
Slovenian: Preverite, če je v brizgi res 1,0 ml vode, nato pa izvlecite iglo iz viale.
English: (There may be solution remaining in the vial.)
Slovenian: (V viali lahko ostane določena količina raztopine.)
English: The aim of the study was to assess efficacy, safety, and tolerability of canakinumab (150 mg or 2 mg/kg every 8 weeks) in patients with CAPS.
Slovenian: Namen študije je bil oceniti učinkovitost, varnost in prenašanje kanakinumaba (150 mg oziroma 2 mg/kg vsakih 8 tednov) pri bolnikih s CAPS.
English: The estimated steady state AUCtau was 636.7 ± 260.2 μg*d/ml.
Slovenian: Ocenjena vrednost AUCtau v stanju dinamičnega ravnovesja je 636,7 ± 260,2 μg*d/ml.
English: Laboratory parameters such as high CRP and SAA, high neutrophils and platelet counts normalised rapidly within days of canakinumab injection.
Slovenian: Laboratorijski parametri, kot so visoke koncentracije CRP, SAA, nevtrofilcev in trombocitov, so se hitro normalizirale v nekaj dneh po injekciji kanakinumaba.
English: Your doctor may check whether you have tuberculosis using a specific test. if you have signs of a liver disorder such as yellow skin and eyes, nausea, loss of appetite, darkcoloured urine and light-coloured stools.
Slovenian: Zdravnik lahko s posebnim testom preveri, ali imate tuberkulozo; če imate znake jetrne bolezni, kot so rumena koža in oči, občutek slabosti, izguba apetita, temno obarvan urin in svetlo blato; če morate biti cepljeni.
English: • Familial Mediterranean fever (FMF).
Slovenian: • družinska mediteranska vročica (angl. familial Mediterranean fever, s kratico FMF).
English: Then gently turn the vial upside down and back again ten times.
Slovenian: Zatem vialo desetkrat nežno obrnite na glavo in spet nazaj.
English: Each vial is for single use in a single patient, for a single dose.
Slovenian: Posamezna viala je namenjena za enkratno uporabo pri posameznem bolniku za odmerjanje enega odmerka.
English: No apparent correlation of antibody development to clinical response or adverse events was observed.
Slovenian: Prav tako niso opažali nobene jasne povezave med razvojem protiteles in kliničnim odzivom oziroma neželenimi dogodki.
English: Ilaris is indicated for the treatment of the following autoinflammatory periodic fever syndromes in adults, adolescents and children aged 2 years and older:
Slovenian: Zdravilo Ilaris je indicirano za zdravljenje naslednjih avtoinflamatornih periodičnih vročinskih sindromov pri odraslih, mladostnikih in otrocih, starih 2 leti ali več:
English: Should vaccination with live vaccines be indicated after initiation of canakinumab treatment, the recommendation is to wait for at least 3 months after the last canakinumab injection and before the next one (see section 4.4).
Slovenian: Če je cepljenje z živim cepivom indicirano po začetku zdravljenja s kanakinumabom, je priporočeno s cepljenjem počakati vsaj 3 mesece po zadnji injekciji kanakinumaba in zdravljenje s kanakinumabom nadaljevati šele 3 mesece po cepljenju (glejte poglavje 4.4).
English: Do not inject into scar-tissue as this may mean you do not get all of your medicine.
Slovenian: Zdravila ne injicirajte v brazgotino, ker bi to lahko pomenilo, da ne boste prejeli celotnega odmerka.
English: 3 Based on estimated creatinine clearance, most were transient 4 Most represented transient trace to 1+ positive urinary protein by dipstick 5 See further information below
Slovenian: 3 glede na ocenjen očistek kreatinina, večinoma so bile vrednosti zvišane le prehodno 4 večina izvidov je pomenila prehodno prisotnost beljakovin v urinu v sledeh oziroma do vrednosti 1+ na testnem lističu 5 za več podatkov glejte spodaj
English: Macrophage activation syndrome (MAS) is a known, life-threatening disorder that may develop in patients with rheumatic conditions, in particular Still's disease.
Slovenian: Sindrom aktivacije makrofagov (macrophage activation syndrome - MAS) je znana, življenjsko nevarna motnja, do katere lahko pride pri bolnikih z revmatičnimi boleznimi, zlasti s Stillovo boleznijo.
English: Your doctor will monitor you for potential triggering factors of MAS that include infections and re-activation of the underlying Still's disease (flare).
Slovenian: Zdravnik vas bo spremljal in opazoval morebiten pojav sprožilnih dejavnikov sindroma aktivacije makrofagov, med katerimi so okužbe in ponovna aktivacija osnovne Stillove bolezni (zagon).
English: Fifty-seven (62%) of the 92 patients who attempted to taper were able to successfully taper their corticosteroid dose and 42 (46%) discontinued corticosteroids.
Slovenian: Sedeminpetdeset (62 %) od 92 bolnikov, ki so začeli postopno opuščanje, je uspelo znižati odmerjanje kortikosteroidov, 42 bolnikov (46 %) pa je povsem prekinilo jemanje kortikosteroidov.
English: In the long-term, open-label studies with dose escalation, events of infections (gastroenteritis, respiratory tract infection, upper respiratory tract infection), vomiting and dizziness were more frequently reported in the 600 mg or 8 mg/kg dose group than in other dose groups.
Slovenian: V dolgoročnih odprtih študijah s stopnjevanjem odmerkov so o dogodkih, ki so obsegali okužbe (gastroenteritis, okužbe dihal, okužbe zgornjih dihal), bruhanje in omotičnost, poročali pogosteje v skupinah bolnikov, ki so prejemali odmerke 600 mg oziroma 8 mg/kg, kot v skupinah z drugimi odmerki.
English: Neutropenia (absolute neutrophil count [ANC] < 1.5 x 10
Slovenian: Nevtropenijo (absolutno število nevtrofilcev < 1,5 x 10
English: Ilaris is used in adults to treat the symptoms of frequent gouty arthritis attacks if other treatments have not worked well enough.
Slovenian: Zdravilo Ilaris uporabljamo pri odraslih za zdravljenje simptomov pri pogostih napadih uričnega artritisa, če druga zdravila pri tem niso bila uspešna.
English: Table 1 Tabulated list of adverse reactions
Slovenian: Preglednica 1 Tabelarični pregled neželenih učinkov
English: For chronic or repeated therapies, it is also recommended to assess WBC counts periodically during treatment.
Slovenian: V primeru kroničnega ali večkratnega zdravljenja je priporočeno določati število levkocitov v rednih presledkih med zdravljenjem.
English: MedDRA System Organ Class
Slovenian: Organski sistem po klasifikaciji MedDRA
English: Use of canakinumab with TNF inhibitors is not recommended because this may increase the risk of serious infections.
Slovenian: Uporaba kanakinumaba z zaviralci TNF ni priporočena, saj bi lahko povečala tveganje za resne okužbe.
English: Part II: In the withdrawal period of the pivotal study, the primary endpoint was defined as the proportion of patients with a disease relapse/flare: none (0%) of the patients randomised to canakinumab flared, compared with 81% of the patients randomised to placebo.
Slovenian: 2. obdobje: V obdobju opuščanja zdravila te ključne študije je bil primarni cilj opazovanja opredeljen kot delež bolnikov s ponovitvijo/zagonom bolezni: do ponovnega zagona ni prišlo pri nobenem (0 %) od bolnikov, ki so bili randomizirani na uporabo kanakinumaba, v primerjavi z 81 % bolnikov, ki so bili randomizirani na uporabo placeba.
English: Release the pinched skin and pull the needle straight out.
Slovenian: Sprostite kožno gubo in naravnost izvlecite iglo.
English: In patients with periodic fever syndromes (CAPS, TRAPS, HIDS/MKD and FMF), the body produces too much IL-1 beta.
Slovenian: Pri bolnikih s periodičnimi vročinskimi sindromi (CAPS, TRAPS, HIDS/MKD in FMF) v telesu nastaja preveč IL-1 beta.
English: If you accidentally inject more Ilaris than the recommended dose, it is unlikely to be serious, but you should inform your doctor, pharmacist or nurse as soon as possible.
Slovenian: Če ste uporabili večji odmerek zdravila Ilaris, kot bi smeli Če si nehote injicirate več zdravila Ilaris, kot je priporočeni odmerek, se vam verjetno ne bo zgodilo nič resnega, vendar morate kljub temu čimprej obvestiti zdravnika, farmacevta ali medicinsko sestro.
English: If drops remain on the stopper, tap the side of the vial to remove them.
Slovenian: Če so na zamašku ostale kapljice tekočine, potrkajte po steni viale, da jih odstranite.