FrancophonIA/ELRC3.0 huggingface dataset:
English: 6.6 Special precautions for disposal and other handling Each vial is for single use only.
Slovenian: 6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom Vsaka viala je namenjena samo za enkratno uporabo.
English: Actual body weight (kg) X standard dose 70 (kg)
Slovenian: dejanska telesna masa (kg) X standardni odmerek 70 (kg)
English: Individual urinary recoveries ranged from 5 to 40%, with an average recovery of 15-20% in several studies.
Slovenian: Individualno pojavljanje v urinu je bilo od 5 do 40%, povprečno pojavljanje v več študijah pa je bilo od 15 do 20%.
English: In studies of 178 paediatric patients ≥3 months of age, the reported adverse reactions were consistent with those reported for adults.
Slovenian: V študijah pri 178 pediatričnih bolnikih, starih ≥ 3 mesece, so se poročani neželeni učinki skladali s tistimi, o katerih so poročali pri odraslih.
English: The risk may vary with the underlying infection, age and general status of the patient so that the contribution of the antibiotic to the increase in INR (international normalised ratio) is difficult to assess.
Slovenian: Tveganje se lahko razlikuje glede na osnovno okužbo, starost in splošno stanje bolnika, tako da je težko oceniti, kolikšen je vpliv antibiotika na povečanje INR (internacionalnega normaliziranega razmerja).
English: Available evidence suggests that cilastatin prevents the nephrotoxicity by preventing entry of imipenem into the tubular cells.
Slovenian: Razpoložljivi dokazi kažejo, da cilastatin prepreči nefrotoksičnost, ker prepreči vstop imipenema v celice tubulov.
English: The medicinal product is supplied in packs of 1 vial, 10 vials and 25 vials.
Slovenian: Zdravilo je opremljeno v pakiranjih z 1 vialo, 10 vialami in 25 vialami.
English: Meningitis TIENAM is not recommended for the therapy of meningitis.
Slovenian: Meningitis Zdravilo TIENAM ni priporočljivo za zdravljenje meningitisa.
English: How to store TIENAM Further information
Slovenian: Shranjevanje zdravila TIENAM Dodatne informacije
English: This medicinal product must not be mixed with other medicinal products except those mentioned under Reconstitution.
Slovenian: Zdravila se ne sme mešati z drugimi zdravili razen s tistimi, ki so omenjena pod Priprava.
English: TIENAM belongs to a group of medicines called carbapenem antibiotics.
Slovenian: Zdravilo TIENAM spada v skupino zdravil, imenovanih karbapenemski antibiotiki.
English: At these doses, plasma levels of imipenem decline to below 1 μg/ml or less in four to six hours.
Slovenian: Pri teh odmerkih se plazemska raven imipenema zmanjša na 1 µg/ml ali manj v štirih do šestih urah.
English: Currently there are inadequate data to recommend use of TIENAM for patients on peritoneal dialysis.
Slovenian: Trenutno ni dovolj podatkov, da bi bilo mogoče priporočiti uporabo zdravila TIENAM pri bolnikih na peritonealni dializi.
English: Like all medicines, TIENAM can cause side effects, although not everybody gets them.
Slovenian: Kot vsa zdravila ima lahko tudi zdravilo TIENAM neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
English: In exceptional circumstances where 0.9% sodium chloride cannot be used for clinical reasons, 5% glucose may be used instead.
Slovenian: V izjemnih primerih, v katerih se zaradi kliničnih razlogov 0,9 % raztopine natrijevega klorida ne more uporabiti, lahko namesto nje uporabite 5 % raztopino glukoze.
English: Rare staining of teeth and/or tongue
Slovenian: Redki obarvanje zob in/ali jezika
English: 1 Proteus and Morganella species are considered poor targets for imipenem.
Slovenian: 1 Vrsti Proteus in Morganella veljata za slaba cilja za imipenem.
English: Paediatric population <1 year of age Clinical data are insufficient to recommend dosing for children less than 1 year of age
Slovenian: Pediatrični bolniki, stari <1 leto Kliničnih podatkov ni dovolj, da bi bilo mogoče priporočiti odmerjanje za otroke, mlajše od 1 leta.
English: • Neisseria gonorrhoeae: There is insufficient evidence that Neisseria gonorrhoeae is a good target for therapy with imipenem.
Slovenian: Neisseria gonorrhoeae: ni dovolj dokazov, da je Neisseria gonorrhoeae primerna za zdravljenje z imipenemom.
English: For infusion times see Method of administration.
Slovenian: Za čas infundiranja glejte Način uporabe.
English: Imipenem and cilastatin are excreted into the mother's milk in small quantities.
Slovenian: Imipenem in cilastatin se v majhni količini izločata v materino mleko.
English: Gram-negative anaerobes: Bacteroides fragilis Bacteroides fragilis group Fusobacterium spp.
Slovenian: Gramnegativni anaerobi: Bacteroides fragilis Bacteroides fragilis skupina Fusobacterium spp.
English: Stenotrophomonas maltophilia (formerly Xanthomonas maltophilia, formerly Pseudomonas maltophilia)
Slovenian: Stenotrophomonas maltophilia (prej Xanthomonas maltophilia, prej Pseudomonas maltophilia)
English: If an allergic reaction to TIENAM occurs, discontinue the therapy immediately.
Slovenian: Če se pojavi alergijska reakcija na zdravilo TIENAM, je treba zdravljenje nemudoma prekiniti.
English: • Infections that you can catch during or after the delivery
Slovenian: • okužbo, ki se lahko pojavi med porodom ali po njem
English: Pack sizes of 1, 10 or 25 vials.
Slovenian: Velikosti pakiranj: 1, 10 ali 25 vial.
English: ** EUCAST non-species related breakpoint is used.
Slovenian: ** Uporabljene so mejne vrednosti po EUCAST, ki niso vezane na vrsto.
English: For storage conditions of the reconstituted medicinal product, see section 6.3.
Slovenian: Za pogoje shranjevanja pripravljenega (rekonstituiranega) zdravila glejte poglavje 6.3.
English: Total daily dose for patients with normal renal function (mg/day)
Slovenian: skupni dnevni odmerek za bolnike z normalnim delovanjem ledvic (mg/dan)
English: Studies in pregnant monkeys have shown reproductive toxicity (see section 5.3).
Slovenian: Študije pri nosečih opicah so pokazale toksične učinke na sposobnost razmnoževanja (glejte poglavje 5.3).
English: These medicinal products should not be used concomitantly unless the potential benefit outweighs the risks.
Slovenian: Teh zdravil se ne sme uporabljati hkrati, razen če možna korist odtehta tveganja.
English: The plasma half-life of cilastatin is approximately one hour.
Slovenian: Plazemski razpolovni čas cilastatina je približno ena ura.
English: Distribution The binding of imipenem to human serum proteins is approximately 20%.
Slovenian: Porazdelitev Vezava imipenema na beljakovine v človeškem serumu je približno 20%.
English: Variations of colour, from colourless to yellow, do not affect the potency of the product.
Slovenian: Spremembe barve od brezbarvne do rumene ne vplivajo na učinkovitost zdravila.
English: Pregnancy There are no adequate and well-controlled studies for the use of imipenem/cilastatin in pregnant women.
Slovenian: Nosečnost Pri nosečnicah ni ustreznih in dobro kontroliranih študij o uporabi imipenema/cilastatina.
English: What TIENAM is and what it is used for Before you use TIENAM How to use TIENAM Possible side effects
Slovenian: Kaj je zdravilo TIENAM in za kaj ga uporabljamo Kaj morate vedeti, preden boste dobili zdravilo TIENAM Kako uporabljati zdravilo TIENAM Možni neželeni učinki
English: The antibacterial spectrum of imipenem/cilastatin should be taken into account especially in lifethreatening conditions before embarking on any empiric treatment.
Slovenian: Protibakterijski spekter imipenema/cilastatina je treba upoštevati predvsem pri smrtno nevarnih stanjih pred uvedbo kakšnega empiričnega zdravljenja.
English: A suggested procedure is to add approximately 10 ml of the appropriate infusion solution to the vial.
Slovenian: Predlagani postopek je, da v vialo dodate približno 10 ml ustrezne raztopine za infundiranje.
English: Activity of dehydropeptidase-I in the kidney returned to normal levels shortly after the elimination of cilastatin from the blood stream.
Slovenian: Aktivnost dehidropeptidaze-I se je v ledvicah normalizirala kmalu po odstranitvi cilastatina iz krvnega obtoka.
English: Very Rare fulminant hepatitis
Slovenian: Zelo redki fulminantni hepatitis
English: Incompatibility
Slovenian: Inkompatibilnost
English: Plasma concentrations
Slovenian: Koncentracija v plazmi
English: • Imipenem may be actively removed from the cell with an efflux pump.
Slovenian: Imipenem se lahko iz celice aktivno odstranjuje z iztočno črpalko.
English: Very rare hyperhidrosis, skin texture changes
Slovenian: Zelo redki hiperhidroza, spremembe teksture kože
English: Paediatric (≥3 months of age)
Slovenian: Pediatrični bolniki ( ≥ 3 mesece starosti)
English: If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically and placed on anticonvulsant therapy if not already instituted.
Slovenian: Če se pojavijo fokalen tremor, mioklonus ali napadi krčev, je bolnike treba nevrološko pregledati in uvesti antikonvulzivno zdravljenje, če ga še ne prejemajo.
English: Renal impairment To determine the reduced dose for adults with impaired renal function:
Slovenian: Okvara ledvic Določitev zmanjšanega odmerka pri odraslih z okvarjenim delovanjem ledvic:
English: The total daily dose (i.e. 2000/2000, 3000/3000 or 4000/4000 mg) that would usually be applicable to patients with normal renal function should be selected.
Slovenian: Izbrati je treba skupni dnevni odmerek (tj. 2.000, 3.000 ali 4.000 mg), ki bi običajno ustrezal bolnikom z normalnim delovanjem ledvic.
English: Germany: ZIENAM
Slovenian: Nemčija: ZIENAM
English: Approximately 70% of the administered antibiotic was recovered intact in the urine within ten hours, and no further urinary excretion of imipenem was detectable.
Slovenian: Približno 70% uporabljenega antibiotika se nespremenjenega izloči v urinu v desetih urah; dodatno izločanje imipenema v urinu ni bilo zaznavno.
English: No specific information is available on treatment of overdose with TIENAM.
Slovenian: O zdravljenju prevelikega odmerjanja zdravila TIENAM ni specifičnih informacij.
English: They are for use only for species not mentioned in the overview of species-related breakpoints or footnotes.
Slovenian: Namenjeni sta samo za uporabo pri vrstah, ki niso omenjene v pregledu mejnih vrednosti, vezanih na vrsto ali opombah.
English: Concomitant use of an appropriate anti-MRSA agent may be indicated when MRSA infections are suspected or proven to be involved in the approved indications.
Slovenian: Sočasna uporaba ustreznega zdravila proti MRSA je lahko indicirana, če so pri odobrenih indikacijah domnevno ali dokazano vpletene okužbe z MRSA.
English: Table 1: Reduced dose in adults with impaired renal function and body weight 70 kg*
Slovenian: Preglednica 1: Zmanjšanje odmerka pri odraslih z okvarjenim delovanjem ledvic in telesno maso 70 kg*
English: Austria: Zienam
Slovenian: Avstrija: Zienam
English: Diluted solutions should be used immediately.
Slovenian: Razredčene raztopine je treba uporabiti takoj.
English: Uncommon psychic disturbances including hallucinations and confusional states
Slovenian: Občasni duševne motnje, vključno s halucinacijami in stanji zmedenosti
English: Simultaneous administration of antibiotics with warfarin may augment its anti-coagulant effects.
Slovenian: Sočasna uporaba antibiotikov in varfarina lahko poveča antikoagulantne učinke varfarina.
English: It is important that you tell your doctor if you are pregnant or are planning to become pregnant before receiving TIENAM.
Slovenian: Pomembno je, da zdravniku poveste, če ste noseči ali nameravate zanositi, preden prejmete zdravilo TIENAM.
English: Very rare pruritus vulvae
Slovenian: Zelo redki pruritus vulvae
English: Special awareness should be made to neurological symptoms or convulsions in children with known risk factors for seizures, or on concomitant treatment with medicinal products lowering the seizures threshold.
Slovenian: Posebno pozornost je treba nameniti nevrološkim simptomom ali napadom krčev pri otrocih z znanimi dejavniki tveganja za napade krčev oz. med sočasnim zdravljenjem z zdravili, ki znižujejo prag za napade krčev.
English: If you forget to use TIENAM
Slovenian: Če ste pozabili uporabiti zdravilo TIENAM
English: The proportionate dose for patients < 70 kg would be calculated using the following formula:
Slovenian: Sorazmerni odmerek za bolnike < 70 kg se izračune po naslednji enačbi:
English: It is devoid of intrinsic antibacterial activity and does not affect the antibacterial activity of imipenem.
Slovenian: Ta snov ne deluje protibakterijsko in ne vpliva na protibakterijsko delovanje imipenema.
English: In patients who develop nausea during the infusion, the rate of infusion may be slowed.
Slovenian: Pri bolnikih, pri katerih se med infundiranjem pojavi navzea, se hitrost infundiranja lahko zmanjša.
English: EUCAST MIC breakpoints for imipenem to separate susceptible (S) pathogens from resistant (R) pathogens are as follows (v 1,1 2010-04-27):
Slovenian: Po EUCAST so mejne vrednosti MIC imipenema za ločevanje občutljivih (O) in rezistentnih (R) patogenov naslednje (v 1.1, 27. 04. 2010):
English: Do not use TIENAM after the expiry date stated on the container.
Slovenian: Zdravila TIENAM ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na vsebniku.
English: These patients should not receive TIENAM unless haemodialysis is instituted within 48 hours.
Slovenian: Ti bolniki ne smejo dobiti zdravila TIENAM, razen če se hemodializa začne v 48 urah.
English: Gram-positive anaerobes:
Slovenian: Grampozitivni anaerobi:
English: The use of imipenem/cilastatin is not suitable for treatment of these types of infections unless the pathogen is already documented and known to be susceptible or there is a very high suspicion that the most likely pathogen(s) would be suitable for treatment.
Slovenian: Uporaba imipenema/cilastatina ni primerna za zdravljenje teh okužb, razen če je patogen že dokumentiran in je zanj znano, da je občutljiv, ali če obstaja zelo utemeljen sum, da je/so najverjetnejši patogen/patogeni primeren/primerni za zdravljenje.
English: The daily dose of TIENAM should be based on the type and severity of infection, the pathogen(s) isolated, the patient's renal function and body weight (see also section 4.4 and 5.1).
Slovenian: Dnevni odmerek zdravila TIENAM mora temeljiti na vrsti in jakosti okužbe, izoliranem patogenu (ali patogenih), bolnikovemu delovanju ledvic in telesni masi (glejte tudi poglavji 4.4 in 5.1).
English: If the use of TIENAM is deemed necessary, the benefit of breast feeding for the child should be weighed against the possible risk for the child.
Slovenian: Če je ocenjeno, da je uporaba zdravila TIENAM nujna, je treba korist dojenja za otroka pretehtati glede na možno tveganja za otroka.
English: A positive direct Coombs' test, prolonged prothrombin time, decreased haemoglobin, increases in serum bilirubin, elevations in serum creatinine, elevations in blood urea nitrogen
Slovenian: Občasni pozitiven neposredni Coombsov test, podaljšan protrombinski čas, znižanje hemoglobina, zvišanje bilirubina v serumu, zvišanje kreatinina v serumu, zvišanje dušika sečnine v krvi
English: TIENAM may be used to treat bacterial infection of the blood which might be associated with a type of infection mentioned above.
Slovenian: Zdravilo TIENAM se lahko uporablja za zdravljenje bakterijskih okužb krvi, ki so lahko povezane z zgoraj omenjenimi vrstami okužb.
English: Repeat with an additional 10 ml of infusion solution to ensure complete transfer of vial contents to the infusion solution.
Slovenian: Ponovite z dodatnimi 10 ml raztopine za infundiranje, da boste zagotovili popoln prenos vsebine viale v raztopino za infundiranje.
English: Distribution The binding of cilastatin to human serum proteins is approximately 40%.
Slovenian: Porazdelitev Vezava cilastatina na beljakovine v človeškem serumu je približno 40%.
English: 5 Non-species related breakpoint have been determined mainly on the basis of PK/PD data and are independent of MIC distributions of specific species.
Slovenian: 5 Mejni vrednosti, ki nista vezani na vrsto, sta bili določeni predvsem na podlagi podatkov o farmakokinetiki/farmakodinamiki in nista odvisni od porazdelitve MIC za posamezno vrsto.
English: Tell your doctor if you are taking medicines called valproic acid or sodium valproate (see Using other medicines below).
Slovenian: Zdravniku povejte, če jemljete zdravila, ki vsebujejo valprojsko kislino ali natrijev valproat (glejte Uporaba drugih zdravil, spodaj).
English: All adverse reactions are listed under system organ class and frequency: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000) and not known (cannot be estimated from the available data).
Slovenian: Zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10), občasni (≥1/1.000 do <1/100), redki (≥1/10.000 do <1/1.000), zelo redki (<1/10.000) in ni znano (ni mogoče oceniti na podlagi podatkov, ki so na voljo).
English: The plasma half-life of imipenem was one hour.
Slovenian: Plazemski razpolovni čas imipenema je ena ura.
English: There are no data available regarding potential effects of imipenem/cilastatin treatment on male or female fertility.
Slovenian: O možnem vplivu zdravljenja z imipenemom/cilastatinom na plodnost pri moških in ženskah ni na voljo nobenih podatkov.
English: • Decreased permeability of the outer membrane of Gram-negative bacteria (due to diminished production of porins)
Slovenian: Manjše permeabilnosti zunanje membrane gramnegativnih bakterij (zaradi zmanjšanega nastajanja porinov).
English: This medicinal product is chemically incompatible with lactate and should not be reconstituted in diluents containing lactate.
Slovenian: Zdravilo je kemično inkompatibilno z laktatom in se ga ne sme pripraviti z vehikli, ki vsebujejo laktat.
English: The selection of imipenem/cilastatin to treat an individual patient should take into account the appropriateness of using a carbapenem antibacterial agent based on factors such as severity of the infection, the prevalence of resistance to other suitable antibacterial agents and the risk of selecting for carbapenem-resistant bacteria.
Slovenian: Pri izbiri imipenema/cilastatina za zdravljenje posameznega bolnika je treba upoštevati ustreznost uporabe karbapenemskega protibakterijskega zdravila na podlagi dejavnikov, kot so jakost okužbe, prevalenca odpornosti na druga primerna protibakterijska zdravila in tveganje, da zdravilo izberemo za bakterije, odporne na karbapenem.
English: The pharmacokinetics of imipenem in patients with hepatic insufficiency have not been established.
Slovenian: Farmakokinetika imipenema pri bolnikih z insuficienco jeter ni raziskana.
English: Staphylococcus coagulase negative (Methicillin-susceptible) Streptococcus agalactiae
Slovenian: Staphylococcus koagulaza-negativen (občutljiv za meticilin) Streptococcus agalactiae
English: 2 The breakpoints for Pseudomonas relate to high dose frequent therapy (1g every 6 hours).
Slovenian: 2 Mejne vrednosti za Pseudomonas so povezane z visokoodmernim pogostim zdravljenjem (1 g na
English: There have been many reports of increases in the anti-coagulant effects of orally administered anticoagulant agents, including warfarin in patients who are concomitantly receiving antibacterial agents.
Slovenian: Poročali so o številnih primerih povečanja antikoagulantnih učinkov peroralnih antikoagulantov, vključno z varfarinom, pri bolnikih, ki so sočasno dobivali protibakterijska zdravila.
English: The proportionate dose for patients <70 kg would be calculated by dividing the patient's actual body weight (in kg) by 70 kg multiplied by the respective dose recommended in Table 1.
Slovenian: Sorazmerni odmerek za bolnike s telesno maso < 70 kg izračunate tako, da bolnikovo dejansko telesno maso (v kg) delite s 70 kg in pomnožite z normalnim odmerkom, priporočenim v preglednici 1.
English: LIST OF EXCIPIENTS Sodium bicarbonate (E500)
Slovenian: SEZNAM POMOŽNIH SNOVI natrijev hidrogenkarbonat (E500)
English: From table 1 the appropriate reduced dose regimen is selected according to the patient's creatinine clearance.
Slovenian: V preglednici 1 izberite ustrezno shemo z zmanjšanim odmerkom glede na bolnikov očistek kreatinina.
English: Rare toxic epidermal necrolysis, angioedema, Stevens-Johnson syndrome, erythema multiforme, exfoliative dermatitis
Slovenian: Redki toksična epidermalna nekroliza, angioedem, Stevens-Johnsonov sindrom, multiformni eritem, eksfoliativni dermatitis
English: The patient should receive TIENAM after haemodialysis and at 12 hour intervals timed from the end of that haemodialysis session.
Slovenian: Bolniki morajo dobiti zdravilo TIENAM po hemodializi in v 12-urnih presledkih od zaključka hemodialize.
English: Use in patients with liver disease: patients with pre-existing liver disorders should have liver function monitored during treatment with imipenem/cilastatin.
Slovenian: Uporaba pri bolnikih z boleznijo jeter: bolnikom z obstoječimi boleznimi jeter je treba med zdravljenjem z imipenemom/cilastatinom kontrolirati delovanje jeter.
English: Tell your doctor about any medical condition you have or have had including: allergies to any medicines including antibiotics (sudden life-threatening allergic reactions require immediate medical treatment) colitis or any other gastrointestinal disease any central nervous system disorders such as localized tremors or epileptic seizures liver, kidney or urinary problems
Slovenian: Zdravniku povejte za vse bolezni, ki jih imate ali ste jih imeli, vključno s/z: alergijami na katerokoli zdravilo, vključno z antibiotiki (nenadne življensko nevarne alergijske reakcije zahtevajo takojšnje zdravljenje), kolitisom ali katerokoli drugo boleznijo prebavil, katerokoli boleznijo osrednjega živčevja, npr. lokaliziranim tremorjem (tresenjem) ali epileptičnimi napadi, težavami z jetri, ledvicami ali sečili.
English: If you have further questions, ask your doctor or pharmacist.
Slovenian: - Če imate dodatna vprašanja, se posvetujte z zdravnikom ali s farmacevtom.
English: These experiences have been reported most commonly in patients with CNS disorders (e.g. brain lesions or history of seizures) and/or compromised renal function in whom accumulation of the administered entities could occur.
Slovenian: O teh izkušnjah so najpogosteje poročali pri bolnikih z motnjami osrednjega živčevja (npr. možganskimi lezijami ali anamnezo konvulzij) in/ali slabšim delovanjem ledvic, pri katerih se lahko pojavi kopičenje uporabljenih snovi.
English: Also, tell your doctor if you are taking valproic acid or sodium valproate (used to treat epilepsy, bipolar disorder, migraine, or schizophrenia) or any blood thinners such as warfarin.
Slovenian: Prav tako zdravniku povejte, če jemljete valprojsko kislino ali natrijev valproat (uporabljata se za zdravljenje epilepsije, bipolarne motnje, migrene ali shizofrenije), ali če jemljete zdravila proti strjevanju krvi, kot je varfarin.
English: This medicinal product must not be mixed with other medicinal products except those mentioned in section 6.6.
Slovenian: Zdravila se ne sme mešati z drugimi zdravili razen s tistimi, ki so navedena v poglavju 6.6. 6.3 Rok uporabnosti
English: Concomitant use of an aminoglycoside may be indicated when Pseudomonas aeruginosa infections are suspected or proven to be involved in the approved indications (see section 4.1).
Slovenian: Sočasna uporaba aminoglikozida je lahko indicirana, če so pri odobrenih indikacijah domnevno ali dokazano vpletene okužbe s Pseudomonas aeruginosa (glejte poglavje 4.1).
English: Species for which acquired resistance may be a problem: Gram-negative aerobes: Acinetobacter baumannii Pseudomonas aeruginosa
Slovenian: Vrste, pri katerih je lahko problem pridobljena odpornost: Gramnegativni aerobi: Acinetobacter baumannii Pseudomonas aeruginosa
English: The mean plasma half-lives of imipenem and cilastatin were 91 ± 7.0 minutes and 69 ± 15 minutes, respectively.
Slovenian: Povprečni plazemski razpolovni čas imipenema je bil 91 ± 7,0 minut in cilastatina 69 ± 15 minut.