FrancophonIA/ELRC3.0 huggingface dataset:
English: You must avoid becoming pregnant or fathering a child. Women must use 2 methods of effective contraception during treatment and for at least 7 months after the last dose of treatment.
Croatian: Žene moraju koristiti 2 metode učinkovite kontracepcije tijekom terapije te najmanje 7 mjeseci nakon zadnje doze terapije.
English: NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION MYLOTARG 5 mg powder for concentrate gemtuzumab ozogamicin
Croatian: MYLOTARG 5 mg prašak za koncentrat gemtuzumab ozogamicin
English: Reporting of side effects
Croatian: Klasifikacija organskih sustava Učestalost
English: • Signs of an infusion reaction, such as a rash, shortness of breath, difficulty breathing, a tight chest,
Croatian: • znakovi reakcije na infuziju kao što je osip, nedostatak zraka, otežano disanje, stezanje u prsnom košu, zimica ili vrućica, bol u leđima tijekom ili nakon infuzije lijeka MYLOTARG
English: • Bleeding
Croatian: • krvarenje
English: f. Pancytopenia includes the following reported PTs: Pancytopenia and Bone marrow failure.
Croatian: Pancitopenija uključuje sljedeće zabilježene preporučene pojmove: pancitopenija i zatajenje funkcije koštane srži.
English: Hepatic impairment
Croatian: Venookluzivna bolest jetre
English: Hazard ratio [95% CI] c p-valued
Croatian: Omjer hazarda [95 % CI]
English: Number of deaths, n (%) Median OS in months [95% CI]a Hazard ratio [95% CI]c p-valued
Croatian: Broj smrtnih slučajeva, n (%) Medijan ukupnog preživljenja u mjesecima [95 % CI]
English: d: Within 30 days from the last dose of MYLOTARG.
Croatian: d: U roku od 30 dana od zadnje doze lijeka MYLOTARG. e: Gdje je analiziran, medijan povrata (definiran kao 20 x 10
English: n. Dyspnoea includes the following reported PTs: Dyspnoea and Dyspnoea exertional.
Croatian: Dispneja uključuje sljedeće zabilježene preporučene pojmove: dispneja i dispneja pri naporu.
English: Hepatic function abnormalt
Croatian: Oštećenje funkcije bubrega
English: • Inspect the reconstituted solution for particulates and discolouration.
Croatian: • Pregledajte rekonstituiranu otopinu kako bi se utvrdilo da ne sadrži strane čestice i nije promijenila boju.
English: Do not take a double dose to make up for a forgotten tablet.
Croatian: Ne uzimajte dvostruku dozu kako biste nadoknadili zaboravljenu tabletu.
English: The optimal duration of treatment has not been formally established.
Croatian: Optimalno trajanje liječenja još nije formalno utvrđeno.
English: • if you have had an allergy or reaction to any medicine used to treat your disease.
Croatian: .• Ako ste imali alergiju ili reakciju na bilo koji lijek koji ste koristili za liječenje Vaše bolesti.
English: None of these analyses were adequately sized to detect differences in outcome in poor metabolisers.
Croatian: Niti jedna od ovih analiza nije bila odgovarajuće veličine kako bi se otkrile moguće razlike u ishodu u slabih metabolizatora.
English: Their frequency is defined using the following conventions: common ( 1/100 to <1/10); uncommon ( 1/1,000 to < 1/100); rare (1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).
Croatian: Njihova je učestalost definirana na sljedeći način: česte (≥1/100, <1/10); manje česte (≥1/1000, <1/100); rijetke (≥1/10 000, <1/1000); vrlo rijetke (<1/10 000, nepoznato (ne može se procijeniti iz dostupnih podataka)).
English: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Croatian: Neiskorišteni lijek ili otpadni materijal valja zbrinuti u skladu s lokalnim propisima.
English: The ACTIVE-A study included patients who could not receive VKA therapy because they were unable or unwilling to receive the treatment.
Croatian: Studija ACTIVE-A uključivala je bolesnike koji nisu mogli primati VKA terapiju zbog toga što nisu bili podobni ili nisu željeli primati terapiju.
English: You should take Clopidogrel Teva Pharma for as long as your doctor continues to prescribe it.
Croatian: Klopidogrel Teva Pharma trebate uzimati sve dok Vam ga liječnik propisuje.
English: • If you are allergic to clopidogrel or any of the other ingredients of this medicine (listed in section 6).
Croatian: • ako ste alergični (preosjetljivi) na klopidogrel ili na neki drugi sastojak ovog lijeka (naveden u dijelu 6)
English: The MAH must ensure that the system of pharmacovigilance, presented in Module 1.8.1 of the Marketing Authorisation, is in place and functioning before and whilst the product is on the market.
Croatian: Nositelj odobrenja mora osigurati da je farmakovigilancijski sustav, prikazan u Modulu 1.8.1. nositelja odobrenja, ustrojen i funkcionalan prije i za vrijeme dok je lijek na tržištu.
English: How to store Clopidogrel Teva Pharma Contents of the pack and other information
Croatian: Kako čuvati Klopidogrel Teva Pharma Sadržaj pakiranja i druge informacije
English: If you take more Clopidogrel Teva Pharma than you should Contact your doctor or the nearest hospital emergency department because of the increased risk of bleeding.
Croatian: Ako uzmete više tableta Klopidogrel Teva Pharma nego što ste trebali: Odmah se morate javiti liječniku ili u najbliži odjel hitne medicinske pomoći zbog povećanog rizika od krvarenja.
English: Some other medicines may influence the use of Clopidogrel Teva Pharma or vice versa.
Croatian: Neki lijekovi mogu utjecati na djelovanje lijeka Klopidogrel Teva Pharma i obratno.
English: Patients who had developed a previous monitored allergic reaction and/or haematological reaction to one thienopyridine may have an increased risk of developing the same or another reaction to another thienopyridine.
Croatian: Bolesnici koji su prethodno razvili alergijsku reakciju i/ili hematološku reakciju na jedan od tienopiridina mogu imati povišeni rizik od razvoja iste ili druge reakcije na drugi tienopiridin.
English: What Clopidogrel Teva Pharma is and what it is used for
Croatian: Što je Klopidogrel Teva Pharma i za što se koristi
English: Clopidogrel has been evaluated for safety in more than 44,000 patients, who have participated in clinical studies, including over 12,000 patients treated for 1 year or more.
Croatian: Sigurnost primjene klopidogrela ispitana je na više od 44 000 bolesnika koji su sudjelovali u kliničkim ispitivanjima, uključujući više od 12 000 bolesnika koji su lijek primali godinu ili više dana.
English: Do not use this medicine after the expiry date which is stated on the carton and on the blister, after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru nakon oznake "EXP".
English: Other medicinal products: A number of other clinical studies have been conducted with clopidogrel and other concomitant medicinal products to investigate the potential for pharmacodynamic and pharmacokinetic interactions.
Croatian: Ostali lijekovi: Provedene su određene kliničke studije s klopidogrelom i nekim drugim istodobno primjenjivanim lijekovima kako bi se ispitala mogućnost farmakodinamičkih i farmakokinetičkih interakcija.
English: Clopidogrel Teva Pharma contains clopidogrel and belongs to a group of medicines called antiplatelet medicinal products.
Croatian: Klopidogrel Teva Pharma sadrži klopidogrel i pripada skupini lijekova koji se nazivaju antitrombocitni lijekovi.
English: Detailed information is available on the European Medicines Agency website: http://www.ema.europa.eu.
Croatian: Detaljnije informacije o ovom lijeku dostupne su na web stranici Europske agencije za lijekove: http://www.ema.europa.eu/
English: You should have been told that ‘oral anticoagulants' are more effective than acetylsalicylic acid or the combined use of Clopidogrel Teva Pharma and acetylsalicylic acid for this condition.
Croatian: Trebalo Vam je biti rečeno da su za ovo stanje 'oralni antikoagulansi' učinkovitiji od acetilsalicilatne kiseline ili kombinirane primjene lijeka Klopidogrel Teva Pharma i acetilsalicilatne kiseline.
English: KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Germany Pharmachemie B.V., Swensweg 5, 2031 GA Haarlem, The Netherlands
Croatian: KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenija TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Njemačka Pharmachemie B.V., Swensweg 5, 2031 GA Haarlem, Nizozemska
English: What Clopidogrel Teva Pharma is and what it is used for What you need to know before you take Clopidogrel Teva Pharma How to take Clopidogrel Teva Pharma Possible side effects
Croatian: Što je Klopidogrel Teva Pharma i za što se koristi Što morate znati prije nego što počnete uzmati Klopidogrel Teva Pharma Kako uzimati Klopidogrel Teva Pharma Moguće nuspojave
English: For any information about this medicinal product, please contact the local representative of the Marketing Authorisation Holder
Croatian: Za sve informacije o ovom lijeku obratite se lokalnom predstavniku nositelja odobrenja za stavljanje u promet gotovog lijeka:
English: Your doctor should have prescribed Clopidogrel Teva Pharma plus acetylsalicylic acid if you cannot take ‘oral anticoagulants' and you do not have a risk of major bleeding
Croatian: Liječnik Vam treba propisati Klopidogrel Teva Pharma i acetilsalicilatnu kiselinu ako ne možete uzimati oralne antikoagulanse te nemate rizik od velikog krvarenja.
English: The ACTIVE-W and ACTIVE-A studies, separate trials in the ACTIVE program, included patients with atrial fibrillation (AF) who had at least one risk factor for vascular events.
Croatian: Studije ACTIVE-W i ACTIVE-A, zasebna ispitivanja u programu ACTIVE, uključivale su bolesnike s fibrilacijom atrija (FA) koji su imali najmanje jedan faktor rizika za krvožilne događaje.
English: Based on enrollment criteria, physicians enrolled patients in ACTIVE-W if they were candidates for vitamin K antagonist (VKA) therapy (such as warfarin).
Croatian: Na osnovi uključujućih kriterija liječnici su bolesnike uključili u studiju ACTIVE-W ako su bili kandidati za terapiju antagonistima vitamina K (kao što je varfarin).
English: For the 28x1 tablets pack size, you can check the day on which you last took the tablet by referring to the calendar printed on the blister.
Croatian: Na pakiranju od 28x1 tableta možete pomoću kalendara otisnutog na blisteru provjeriti dan kada ste zadnji put uzeli tabletu Klopidogrel Teva Pharma.
English: If you forget to take a dose of Clopidogrel Teva Pharma, but remember within 12 hours of your usual time, take your tablet straightaway and then take your next tablet at the usual time.
Croatian: Ako zaboravite uzeti jednu dozu lijeka Klopidogrel Teva Pharma, ali se toga sjetite u roku od 12 sati, odmah uzmite tabletu, a sljedeću tabletu uzmite u uobičajeno vrijeme.
English: This was associated with a reduction of the mean inhibition of platelet aggregation by 15% and 11%, respectively.
Croatian: To je bilo povezano sa smanjenjem prosječne vrijednosti inhibicije agregacije trombocita od 15%, odnosno 11%.
English: There have been a number of retrospective analyses, however, to evaluate this effect in patients treated with clopidogrel for whom there are genotyping results: CURE (n=2721), CHARISMA (n=2428), CLARITY-TIMI 28 (n=227), TRITON-TIMI 38 (n=1477), and ACTIVE-A (n=601), as well as a number of published cohort studies.
Croatian: Međutim, postoji veći broj retrospektivnih analiza za procjenu ovog učinka u bolesnika liječenih klopidogrelom, a za koje postoje rezultati genotipizacije: CURE (n=2721), CHARISMA (n=2428), CLARITY-TIMI 28 (n=227), TRITON-TIMI 38 (n=1477) te ACTIVE-A (n=601), kao i određeni broj objavljenih kohortnih kliničkih studija.
English: Other medicines and Clopidogrel Teva Pharma Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines, including medicines obtained without a prescription.
Croatian: Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzimali neke druge lijekove, uključujući i one koje ste nabavili bez recepta.
English: Clopidogrel and the main circulating (inactive) metabolite bind reversibly in vitro to human plasma proteins (98 % and 94 % respectively).
Croatian: Klopidogrel i glavni cirkulirajući (neaktivni) metabolit reverzibilno se in vitro vežu za proteine u ljudskoj plazmi (98%, odnosno 94%).
English: What you need to know before you take Clopidogrel Teva Pharma
Croatian: Što morate znati prije nego počnete uzimati Klopidogrel Teva Pharma
English: If you become pregnant while taking Clopidogrel Teva Pharma, consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant.
Croatian: Ako zatrudnite za vrijeme uzimanja lijeka Klopidogrel Teva Pharma, odmah se posavjetujte s liječnikom jer nije preporučeno uzimati klopidogrel za vrijeme trudnoće.
English: Pharmacotherapeutic group: Antithrombotic agents, platelet aggregation inhibitors excl. heparin, ATC Code: B01AC-04.
Croatian: Farmakoterapijska skupina: inhibitori agregacije trombocita izuzev heparina, ATK oznaka: B01AC04.
English: Then, the recommended dose is one 75 mg tablet of Clopidogrel Teva Pharma per day as described above.
Croatian: Nakon toga, preporučena doza Klopidogrela Teva Pharma je jedna tableta od 75 mg dnevno, kao što je opisano iznad.
English: Other alleles associated with absent or reduced metabolism are less frequent and include CYP2C19*4, *5, *6, *7, and *8.
Croatian: Ostali aleli povezani s odsutnim ili smanjenim metabolizmom uključuju CYP2C19*4, *5, *6, *7 i *8, ali oni su manje zastupljeni.
English: If you have experienced severe chest pain (unstable angina or heart attack), you may be prescribed Clopidogrel Teva Pharma in combination with acetylsalicylic acid, a substance present in many medicines used to relieve pain and lower fever.
Croatian: Ako ste imali jaku bol u prsištu (nestabilna angina ili srčani udar), liječnik Vam može propisati Klopidogrel Teva Pharma u kombinaciji s acetilsalicilatnom kiselinom, tvari prisutnom u mnogim lijekovima za ublažavanje boli i snižavanje temperature.
English: SPECIAL PRECAUTIONS FOR DISPOSAL OF UNUSED MEDICINAL PRODUCTS OR WASTE MATERIALS DERIVED FROM SUCH MEDICINAL PRODUCTS, IF APPROPRIATE
Croatian: POSEBNE MJERE ZA UKLANJANJEZBRINJAVANJE NEISKORIŠTENOG LIJEKA ILI OTPADNIH MATERIJALA KOJI POTJEČU
English: The recommended dose, including for patients with a condition called ‘atrial fibrillation' (an irregular heartbeat), is one 75 mg tablet of Clopidogrel Teva Pharma per day to be taken orally with or without food, and at the same time each day.
Croatian: Preporučena doza, uključujući za bolesnike sa stanjem zvanim "fibrilacija atrija" (nepravilni otkucaji srca), je jedna tableta lijeka Klopidogrel Teva Pharma od 75 mg dnevno koja se uzima kroz usta, s obrokom ili bez obroka, i u isto vrijeme svaki dan.
English: The use of clopidogrel in CURE was associated with a decrease in the need of thrombolytic therapy (RRR = 43.3%; CI: 24.3%, 57.5%) and GPIIb/IIIa inhibitors (RRR = 18.2%; CI: 6.5%, 28.3%).
Croatian: Primjena klopidogrela u studiji CURE bila je povezana sa smanjenjem potrebe za trombolitičkom terapijom (RRR=43,3%; CI: 24,3%, 57,5%) i inhibitorima GPIIb/IIIa (RRR=18,2%; CI: 6,5%, 28,3%).
English: Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD) interaction in terms of major cardiovascular events have been reported from both observational and clinical studies.
Croatian: Podaci prijavljeni i iz opservacijskih i iz kliničkih studija o kliničkim implikacijama ove farmakokinetičke (PK)/farmakodinamičke (PD) interakcije u smislu značajnih kardiovaskularnih događaja nisu konzistentni.
English: In a relative bioavailability study in adults, the constituted solution of clopidogrel showed a similar extent and slightly higher rate of absorption of the main circulating (inactive) metabolite compared to the authorised tablet.
Croatian: U relativnoj studiji bioraspoloživosti lijeka u odraslih, konstituirana otopina klopidogrela pokazala je sličan raspon i neznatno veću brzinu apsorpcije glavnog cirkulirajućeg (inaktivnog) metabolita u usporedbi s tabletom.
English: EU/1/09/561/001 7 film-coated tablets EU/1/09/561/002 14 film-coated tablets EU/1/09/561/003 28 film-coated tablets EU/1/09/561/004 30 film-coated tablets EU/1/09/561/005 50 film-coated tablets EU/1/09/561/006 56 film-coated tablets EU/1/09/561/007 84 film-coated tablets EU/1/09/561/008 90 film-coated tablets EU/1/09/561/009 100 film-coated tablets EU/1/09/561/010 28x1 film-coated tablets EU/1/09/561/011 50x1 film-coated tablets
Croatian: EU/1/09/561/001 7 filmom obloženih tableta EU/1/09/561/002 14 filmom obloženih tableta EU/1/09/561/003 28 filmom obloženih tableta EU/1/09/561/004 30 filmom obloženih tableta EU/1/09/561/005 50 filmom obloženih tableta EU/1/09/561/006 56 filmom obloženih tableta EU/1/09/561/007 84 filmom obloženih tableta EU/1/09/561/008 90 filmom obloženih tableta EU/1/09/561/009 100 filmom obloženih tableta EU/1/09/561/010 28x1 filmom obloženih tableta EU/1/09/561/011 50x1 filmom obloženih tableta
English: Seventy-three percent (73%) of patients enrolled into the ACTIVE-A study were unable to take VKA due to physician assessment, inability to comply with INR (international normalised ratio) monitoring, predisposition to falling or head trauma, or specific risk of bleeding; for 26% of the patients, the physician's decision was based on the patient's unwillingness to take VKA.
Croatian: 73% bolesnika uključenih u studiju ACTIVE-A nisu bili sposobni uzimati terapiju VKA prema procjeni liječnika, zbog nemogućnosti praćenja INR (International Normalised Ratio), zbog sklonosti padanju ili traumatskim ozljedama glave ili zbog specifičnog rizika od krvarenja; za 26% bolesnika odluka liječnika bila je temeljena na nevoljnosti bolesnika za uzimanje terapije VKA.
English: The safety and efficacy of clopidogrel have been evaluated in 5 double-blind studies involving over 88,000 patients: the CAPRIE study, a comparison of clopidogrel to ASA, and the CURE, CLARITY, COMMIT and ACTIVE-A studies comparing clopidogrel to placebo, both medicinal products given in combination with ASA and other standard therapy.
Croatian: Sigurnost primjene i djelotvornost klopidogrela procijenjena je u 5 dvostrukoslijepih studija koje su uključivale više od 88 000 bolesnika: studija CAPRIE, u kojoj su uspoređivani klopidogrel i ASK, te studije CURE, CLARITY, COMMIT i ACTIVE-A u kojima je uspoređivano djelovanje klopidogrela u odnosu na placebo, a obje su terapije davane u kombinaciji s ASK i drugom standardnom terapijom.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER (28x1 film-coated tablets)
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP (BLISTER 28x1 filmom obloženih tableta)
English: Each film-coated tablet contains 13 mg of hydrogenated castor oil.
Croatian: Jedna filmom obložena tableta sadrži 13 mg hidrogeniranog ricinusovog ulja.
English: Less pronounced reductions of metabolite exposure has been observed with pantoprazole or lansoprazole.
Croatian: Manje izraženo smanjenje izloženosti aktivnom metabolitu klopidogrela opaženo je kod primjene pantoprazola i lanzoprazola.
English: If you have experienced severe chest pain (unstable angina or heart attack), your doctor may give you 300 mg of Clopidogrel Teva Pharma (4 tablets of 75 mg) once at the start of treatment.
Croatian: Ako ste imali jake bolove u prsištu (nestabilna angina ili srčani udar), liječnik Vam u početku liječenja može jednokratno dati 300 mg Klopidogrela Teva Pharma (4 tablete od po 75 mg).
English: • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Croatian: • Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari navedenih u dijelu 2 ili dijelu 6.1.
English: Driving and using machines Clopidogrel Teva Pharma is unlikely to affect your ability to drive or to use machines.
Croatian: Upravljanje vozilima i strojevima Klopidogrel Teva Pharma ne bi trebao utjecati na Vašu sposobnost upravljanja vozilima ili strojevima.
English: 7 film-coated tablets 14 film-coated tablets 28 film-coated tablets 30 film-coated tablets 50 film-coated tablets 56 film-coated tablets 84 film-coated tablets 90 film-coated tablets 100 film-coated tablets 28x1 film-coated tablets 50x1 film-coated tablets
Croatian: 7 filmom obloženih tableta 14 filmom obloženih tableta 28 filmom obloženih tableta 30 filmom obloženih tableta 50 filmom obloženih tableta 56 filmom obloženih tableta 84 filmom obložene tablete 90 filmom obloženih tableta 100 filmom obloženih tableta 28x1 filmom obloženih tableta 50x1 filmom obloženih tableta
English: - fluconazole or voriconazole, medicines to treat fungal infections, - efavirenz, a medicine to treat HIV (human immunodeficiency virus) infections, - carbamazepine, a medicine to treat some forms of epilepsy, - moclobemide, medicine to treat depression, - repaglinide, medicine to treat diabetes, - paclitaxel, medicine to treat cancer.
Croatian: - flukonazol ili vorikonazol, odnosno lijekove koji se primjenjuju za liječenje gljivičnih infekcija, - efavirenz, lijek koji se primjenjuje za liječenje HIV (virus humane imunodeficijencije) infekcija, - karbamazepin, lijek koji se primjenjuje za liječenje nekih oblika epilepsije, - moklobemid, lijek za liječenje depresije, - repaglinid, lijek za liječenje dijabetesa, - paklitaksel, lijek za liječenje raka.
English: However, concomitant administration of 500 mg of ASA twice a day for one day did not significantly increase the prolongation of bleeding time induced by clopidogrel intake.
Croatian: Međutim istodobna primjena 500 mg ASK dva puta na dan tijekom jednog dana nije značajno produljila vrijeme krvarenja, već produljeno uzimanjem klopidogrela.
English: Patients randomized in the ACTIVE program were those presenting with documented AF, i.e., either permanent AF or at least 2 episodes of intermittent AF in the past 6 months, and had at least one of the following risk factors: age 75 years or age 55 to 74 years and either diabetes mellitus requiring drug therapy, or documented previous MI or documented coronary artery disease; treated for systemic hypertension; prior stroke, transient ischaemic attack (TIA), or non-CNS systemic embolus; left ventricular dysfunction with left ventricular ejection fraction <45%; or documented peripheral vascular disease.
Croatian: Bolesnici randomizirani u programu ACTIVE imali su dokumentiranu fibrilaciju atrija (FA), tj. ili permanentnu FA ili najmanje 2 epizode intermitentne FA u zadnjih 6 mjeseci te su imali najmanje jedan od sljedećih faktora rizika: dob ≥75 godina ili 55 do 74 godine te ili dijabetes koji zahtijeva terapiju lijekovima ili dokumentirani prethodni infarkt miokarda ili dokumentiranu bolest koronarnih arterija; ako su primali terpiju za sistemsku hipertenziju; prethodni moždani udar, prolazni ishemijski napadaj (TIA) ili ne-CNS sistemska embolija; disfunkcija lijevog ventrikula s ejekcijskom frakcijom lijevog ventrikula <45% ili dokumentirana periferna vaskularna bolest.
English: For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.
Croatian: - Ako je prošlo više od 12 sati: bolesnik treba sljedeću dozu uzeti prema uobičajenom rasporedu i ne smije uzeti dvostruku dozu.
English: Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Croatian: Omeprazol primjenjen u dozi od 80 mg na dan, istodobno s klopidogrelom ili s razmakom od 12 sati od primjene dvaju lijekova, smanjio je koncentraciju aktivnog metabolita klopidogrela za 45% (udarna doza) i 40% (doza održavanja).