FrancophonIA/ELRC3.0 huggingface dataset:
English: The final analysis was performed when all patients had reached their 10-year follow-up visit (unless they had a DFS event or were lost to follow up before).
Croatian: Konačna analiza provedena je nakon što su svi bolesnici dosegli 10 godina praćenja (osim ako ranije nisu imali DFS događaj ili su ranije prestali biti praćeni).
English: Patients who have developed severe hypersensitivity reactions should not be re-challenged with docetaxel.
Croatian: Bolesnici u kojih su se razvile teške reakcije preosjetljivosti ne smiju se ponovo liječiti docetakselom.
English: • ventricular arrhythmia or ventricular tachycardia (manifested as irregular and/or rapid heartbeat, severe shortness of breath, dizziness, and/or fainting).
Croatian: • ventrikularna aritmija ili ventrikularna tahikardija (koja se manifestira kao nepravilni i/ili ubrzani otkucaji srca, teški nedostatak zraka, omaglica i/ili nesvjestica).
English: • at the injection site, skin reactions, phlebitis (inflammation of the vein) or swelling
Croatian: • na mjestu injiciranja: kožne reakcije, flebitis (upala vena) ili oticanje
English: The adverse reactions considered to be possibly or probably related to the administration of docetaxel have been obtained in:
Croatian: Nuspojave koje su moguće ili vjerojatno povezane s primjenom docetaksela zabilježene su u:
English: The combined administration of docetaxel, cisplatin and 5-fluorouracil in 12 patients with solid tumours had no influence on the pharmacokinetics of each individual medicinal product.
Croatian: Kombinirana primjena docetaksela, cisplatina i 5-fluorouracila u 12 bolesnika sa solidnim tumorima nije utjecala na pojedinačnu farmakokinetiku tih lijekova.
English: In the case of severe neutropenia (< 500 cells/mm3 for seven days or more) during a course of docetaxel therapy, a reduction in dose for subsequent courses of therapy or the use of appropriate symptomatic measures are recommended (see section 4.2).
Croatian: U slučajevima teške neutropenije ( 500 stanica/mm3 u trajanju od sedam dana ili dulje) za vrijeme liječenja docetakselom preporuča se smanjenje doze u sljedećim ciklusima liječenja ili primjena odgovarajućih simptomatskih mjera (vidjeti dio 4.2).
English: There is no known antidote for docetaxel overdose.
Croatian: Nije poznat antidot za predoziranje docetakselom.
English: In patients treated with the TAC regimen for node positive breast cancer, the risk of CHF has been shown to be higher during the first year after treatment (see sections 4.8 and 5.1).
Croatian: U bolesnika liječenih TAC režimom zbog karcinoma dojke s pozitivnim limfnim čvorovima, pokazalo se da je rizik od kongestivnog srčanog zatajenja veći tijekom prve godine nakon liječenja (vidjeti dio 4.8 i 5.1).
English: If not used immediately, in-use storage times and conditions are the responsibility of the user.
Croatian: Ako se ne upotrijebi odmah, vrijeme i uvjeti čuvanja lijeka u uporabi su odgovornost korisnika.
English: Use the vial immediately after its opening.
Croatian: Upotrijebite bočicu lijeka odmah nakon otvaranja.
English: (49.0-NA)
Croatian: (49,0-NP)
English: Very rare cases of transient visual disturbances (flashes, flashing lights, scotomata) typically occurring during infusion of the medicinal product and in association with hypersensitivity reactions have been reported.
Croatian: Vrlo su rijetko zabilježeni prolazni poremećaji vida (bljeskovi, svjetlucanja, skotomi) koji se tipično pojavljuju tijekom infuzije lijeka udruženi s reakcijama preosjetljivosti.
English: Overall Response Rate (CR+PR) (%) p-value
Croatian: Stopa ukupnog odgovora (CR+PR) (%) p-vrijednost
English: For storage conditions of the diluted medicinal product, see section 6.3.
Croatian: Za uvjete čuvanja razrijeđenog lijeka vidjeti dio 6.3.
English: Survival data, median time to progression and response rates for two arms of the study are illustrated in the following table:
Croatian: Preživljenje, medijan vremena do progresije bolesti i stopa terapijskog odgovora za dva kraka ispitivanja prikazani su u sljedećoj tablici:
English: In the pivotal study the initial docetaxel infusion was started the day following the first dose of trastuzumab.
Croatian: U pivotalnoj kliničkoj studiji inicijalna infuzija docetaksela započela se primjenjivati dan nakon prve doze trastuzumaba.
English: If the vials are stored under refrigeration, allow the required number of boxes of DOCETAXEL KABI concentrate for solution for infusion to stand below 25°C for 5 minutes before use.
Croatian: Ako su bočice pohranjene u hladnjaku, izvadite potreban broj kutija DOCETAXEL KABI koncentrata za otopinu za infuziju iz hladnjaka i ostavite ih na temperaturi ispod 25°C 5 minuta prije primjene.
English: In a pharmacokinetic study with 7 patients, the co-administration of docetaxel with the strong CYP3A4 inhibitor ketoconazole leads to a significant decrease in docetaxel clearance by
Croatian: U farmakokinetičkoj studiji na 7 bolesnika, istovremena primjena docetaksela sa snažnim inhibitorom CYP3A4, ketokonazolom, dovodi do značajnog pada u klirensu decetaksela za
English: NA-not applicable
Croatian: NP- nije primjenjivo
English: • Overall response rate (ORR) was significantly higher in the AT arm versus AC arm, p = 0.009.
Croatian: • Ukupna stopa terapijskog odgovora (ORR) bila je značajno veća u AT skupini u odnosu na AC skupinu, p=0,009.
English: Prednisone or prednisolone 5 mg orally twice daily is administered continuously (see section 5.1).
Croatian: Prednizon ili prednizolon u dozi od 5 mg oralno dva puta dnevno primjenjuje se kontinuirano (vidjeti dio 5.1).
English: Symptoms such as early abdominal pain and tenderness, fever, diarrhoea, with or without neutropenia, may be early manifestations of serious gastrointestinal toxicity and should be evaluated and treated promptly.
Croatian: Simptomi poput rane pojave bolova u abdomenu i osjetljivosti na dodir, vrućice, proljeva s ili bez neutropenije, mogu biti rani znaci teške gastrointestinalne toksičnosti koju treba brzo procijeniti i liječiti.
English: General disorders and administration site conditions The median cumulative dose to treatment discontinuation was more than 1,000 mg/m2 and the median time to fluid retention reversibility was 16.4 weeks (range 0 to 42 weeks).
Croatian: Medijan kumulativne doze do prekida liječenja bio je veći od 1000 mg/m2, a medijan vremena do reverzibilnosti retencije tekućine bilo je 16,4 tjedana (u rasponu od 0 do 42 tjedna).
English: In non clinical studies, docetaxel has genotoxic effects and may alter male fertility (see section 5.3).
Croatian: Neklinička ispitivanja pokazuju da docetaksel ima genotoksične učinke i da može utjecati na plodnost muškaraca (vidjeti dio 5.3).
English: In this study, 87% of patients had disease that was IHC 3+, and 95% of patients entered had disease that was IHC 3+ and/or FISH positive.
Croatian: U ovoj studiji 87% bolesnika imalo je IHC 3+, a 95% uključenih bolesnika imalo je IHC 3+ i/ili FISH pozitivne rezultate.
English: The development of severe peripheral neurotoxicity requires a reduction of dose (see section 4.2).
Croatian: Razvoj teške periferne neurotoksičnosti zahtijeva smanjenje doze (vidjeti dio 4.2).
English: Docetaxel has been shown in vitro to disrupt the microtubular network in cells which is essential for vital mitotic and interphase cellular functions.
Croatian: In vitro ispitivanja pokazuju da docetaksel kida mikrotubularnu mrežu u stanicama koja je neophodna za vitalne mitotičke i interfazne stanične funkcije.
English: • decrease in blood pressure; irregular or rapid heart beat
Croatian: • pad krvnog tlaka, nepravilni ili brzi otkucaiji srca
English: These patients should be closely monitored during initiation of docetaxel therapy.
Croatian: Ti bolesnici se moraju biti pobliže pratiti na početku terapije docetakselom.
English: Patients treated with TPF experienced significantly less deterioration of their Global health score compared to those treated with PF (p = 0.01, using the EORTC QLQ-C30 scale).
Croatian: Bolesnici liječeni s TPF imali su značajno manje pogoršanje ukupnog zdravstvenog stanja prema bolesnicima liječenim s PF (p=0,01, prema EORTC QLQ-C30 ljestvici).
English: The use of docetaxel should be confined to units specialised in the administration of cytotoxic chemotherapy and it should only be administered under the supervision of a physician qualified in the use of anticancer chemotherapy (see section 6.6).
Croatian: Docetaksel se smije primjenjivati samo na odjelima specijaliziranim za primjenu citotoksične kemoterapije i to isključivo pod nadzorom liječnika kvalificiranog za primjenu antitumorske kemoterapije (vidjeti dio 6.6).
English: • Mitoxantrone 12 mg/m2 every 3 weeks for 10 cycles.
Croatian: • Mitoksantron 12 mg/m2 svaka 3 tjedna tijekom 10 ciklusa.
English: Rare occurrences of dehydration have been reported as a consequence of gastrointestinal events including enterocolitis and gastrointestinal perforation.
Croatian: Rijetke pojave dehidracije zabilježene su kao posljedica gastrointestinalnih poremećaja, uključujući enterokolitis i gastrointestinalnu perforaciju.
English: Undesirable effects on the testis observed in rodent toxicity studies suggest that docetaxel may impair male fertility.
Croatian: Neželjeni učinci na testisima, zamijećeni u ispitivanjima toksičnosti na glodavcima, pokazuju da bi docetaksel mogao oštetiti plodnost u muškaraca.
English: Docetaxel is a lipophilic substance but it is not known whether it is excreted in human milk.
Croatian: Docetaksel je lipofilna tvar, ali nije poznato izlučuje li se u majčino mlijeko.
English: Previous chemotherapy should have included an anthracycline or an alkylating agent.
Croatian: Prethodna kemoterapija morala je uključivati antraciklin ili alkilirajući agens.
English: Tell your doctor, hospital pharmacist, or nurse immediately if you have abdominal pain or tenderness, diarrhoea, rectal haemorrhage, blood in stool or fever.
Croatian: Odmah obavijestite svog liječnika, bolničkog ljekarnika ili medicinsku sestru ako imate bol u trbuhu ili osjetljivost na dodir, proljev, krvarenje iz završnog dijela debelog crijeva (rektuma), krv u stolici ili vrućicu.
English: When used in combination, docetaxel does not influence the clearance of doxorubicin and the plasma levels of doxorubicinol (a doxorubicin metabolite).
Croatian: Kad se primjenjuje u kombinaciji, docetaksel ne utječe na klirens doksorubicina i razinu doksorubicinola u plazmi (metabolita doksorubicina).
English: Blood and lymphatic system disorders Rare: bleeding episodes associated with grade 3/4 thrombocytopenia.
Croatian: Poremećaji krvi i limfnog sustava Rijetko: epizode krvarenja povezane s trombocitopenijom stupnja 3/4.
English: Do not use this medicine after the expiry date which is stated on the outer carton and on the label of the vial after Exp.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i naljepnici bočice iza oznake „Exp “.
English: Radiation was delivered with megavoltage equipment using once daily fractionation (2 Gy per day, 5 days per week for 7 weeks, for a total dose of 70-72 Gy).
Croatian: Radioterapija je provedena na megavoltažnim uređajima uz frakcioniranje jednom dnevno (2 Gy dnevno, 5 dana tjedno kroz 7 tjedana, u ukupnoj dozi od 70-72 Gy).
English: Median survival was 442 days (docetaxel + capecitabine) vs. 352 days (docetaxel alone).
Croatian: Medijan preživljenja je bio 442 dana (docetaksel + kapecitabin) u odnosu na 352 dana (samo docetaksel).
English: Treatment difference: 7.1% [95% CI: 0.7; 13.5] *: Corrected for multiple comparisons and adjusted for stratification factors (stage of disease and region of treatment), based on evaluable patient population.
Croatian: Razlika u liječenju: 7,1% [95% CI: 0,7; 13,5] * Korigirano za višestruku usporedbu i prilagođeno faktorima stratifikacije (stadij bolesti i regija liječenja) na osnovu podataka iz populacije bolesnika koji su se mogli procijeniti.
English: Docetaxel is administered as a one-hour infusion every three weeks.
Croatian: Docetaksel se primjenjuje u obliku jednosatne infuzije svaka tri tjedna.
English: Toxic deaths occurred in 1 patient in the AT arm (congestive heart failure) and in 4 patients in the AC arm (1 due to septic shock and 3 due to congestive heart failure).
Croatian: Toksična smrt zabilježena je u 1 bolesnika u AT skupini (kongestivno zatajenje srca) i u 4 bolesnika u AC skupini (1 zbog septičnog šoka i 3 zbog kongestivnog zatajenja srca).
English: • Induction chemotherapy followed by radiotherapy (TAX 323)
Croatian: • Indukcijska kemoterapija praćena radioterapijom (TAX 323)
English: PARTICULARS TO APPEAR ON OUTER PACKAGING OUTER CARTON
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA
English: Mild to moderate neuro-sensory signs are characterised by paraesthesia, dysesthesia or pain including burning.
Croatian: Blagi do umjereni neurosenzorni znaci karakterizirani su parestezijom, disestezijom ili boli uključujući pečenje.
English: Febrile neutropenia and neutropenic infection occurred respectively in 12.1% and 3.4% of patients when patients received prophylactic G-CSF, in 15.6% and 12.9% of patients without prophylactic G-CSF (see section 4.2).
Croatian: Febrilna neutropenija i neutropenijska infekcija javile su se u 12,1% odnosno 3,4% bolesnika koji su profilaktički primali G-CSF i u 15,6% i 12,9% bolesnika koji nisu profilaktički primali G-CSF (vidjeti dio 4.2).
English: (19.3-NA)
Croatian: (19,3-NP)
English: Time to progressive disease was superior in the docetaxel + capecitabine combination arm (p < 0.0001).
Croatian: Vrijeme do progresije bolesti je bilo dulje u skupini koja je primala kombinaciju docetaksel + kapecitabin (p<0,0001).
English: Neutropenia is the most frequent adverse reaction of docetaxel.
Croatian: Neutropenija je najčešća nuspojava docetaksela.
English: OTHER SPECIAL WARNING(S), IF NECESSARY Cytotoxic
Croatian: DRUGO(A) POSEBNO(A) UPOZORENJE(A), AKO JE POTREBNO Citotoksično
English: The pharmacokinetic profile of cisplatin administered shortly after docetaxel infusion is similar to that observed with cisplatin alone.
Croatian: Farmakokinetički profil cisplatina primijenjenog kratko nakon infuzije docetaksela sličan je onom kad se cisplatin daje sam.
English: Neutrophil nadirs occurred at a median of 7 days but this interval may be shorter in heavily pre-treated patients.
Croatian: Najniža razina neutrofila pojavljuje se s medijanom od 7 dana, iako taj interval može biti kraći u bolesnika koji su ranije primali vrlo visoke terapijske doze.
English: Abdominal pain upper; Dry mouth
Croatian: bol u gornjem abdomenu suhoća usta
English: Hypersensitivity reactions have generally occurred within a few minutes following the start of the infusion of docetaxel and were usually mild to moderate.
Croatian: Reakcije preosjetljivosti općenito su se javile unutar nekoliko minuta nakon početka infuzije docetaksela i uglavnom su bile blage do umjerene.
English: Subgroup analyses across age, gender and race consistently favoured the TCF arm compared to the CF arm.
Croatian: Analize podskupina na osnovi dobi, spola i rase bile su u korist TCF skupine prema CF skupini.
English: • infections, decrease in the number of red (anaemia), or white blood cells (which are important in fighting infection) and platelets
Croatian: • infekcije, smanjenje broja crvenih krvnih stanica (anemija) ili bijelih krvnih stanica
English: When combined to docetaxel, the clearance of carboplatin was about 50% higher than values previously reported for carboplatin monotherapy.
Croatian: Kada se primjenjivao zajedno s docetakselom, klirens karboplatina bio je oko 50% veći u odnosu na vrijednosti koje su ranije zabilježene u monoterapiji karboplatinom.
English: In both arms, after the last cycle of chemotherapy, patients with positive oestrogen and/or progesterone receptors received tamoxifen 20 mg daily for up to 5 years.
Croatian: U obje su skupine, nakon zadnjeg ciklusa kemoterapije, bolesnici s pozitivnim estrogenskim i/ili progesteronskim receptorima primali tamoksifen 20 mg dnevno u trajanju od 5 godina.
English: Three docetaxel patients (2%) discontinued the treatment due to fluid retention, whereas 15 doxorubicin patients (9%) discontinued due to cardiac toxicity (three cases of fatal congestive heart failure).
Croatian: Tri bolesnika koji su primali docetaksel (2%) prekinuli su liječenje zbog retencije tekućine, dok je 15 bolesnika koji su primali doksorubicin (9%) prekinulo liječenje zbog kardiotoksičnosti (tri slučaja fatalnog kongestivnog zatajenja srca).
English: The updated analysis was performed when all patients had reached their 10-year (median follow up time of 10 years and 5 months) follow-up visit (unless they had a DFS event or were lost to follow-up previously).
Croatian: Dopunska analiza provedena je nakon što su svi bolesnici dosegli 10 godina (medijan vremena praćenja od 10 godina i 5 mjeseci) praćenja (osim ako ranije nisu imali DFS događaj ili su ranije bili izgubljeni u praćenju).
English: As with other cytotoxic medicinal products, docetaxel may cause foetal harm when administered to pregnant women.
Croatian: Kao i drugi citostatici, docetaksel može oštetiti fetus kada se daje trudnicama.
English: For patients with operable node-negative breast cancer, adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer (see section 5.1).
Croatian: U bolesnika s operabilnim karcinomom dojke i negativnim limfnim čvorovima adjuvantno liječenje treba ograničiti samo na bolesnike koji su prikladni za primanje kemoterapije prema međunarodno utvrđenim kriterijima za primarnu terapiju ranog karcinoma dojke (vidjeti dio 5.1).
English: In combination with cisplatin and 5-fluorouracil
Croatian: Kombinacija s cisplatinom i 5-fluorouracilom
English: Although the possible in vivo interaction of docetaxel with concomitantly administered medicinal product has not been investigated formally, in vitro interactions with tightly protein-bound agents such as erythromycin, diphenhydramine, propranolol, propafenone, phenytoin, salicylate, sulfamethoxazole and sodium valproate did not affect protein binding of docetaxel.
Croatian: Iako mogućnost interakcije docetaksela s istodobnom primjenom drugih lijekova in vivo nije formalno ispitana, in vitro interakcije s tvarima koje se čvrsto vezuju za proteine, poput eritromicina, difenhidramina, propranolola, propafenona, fenitoina, salicilata, sulfametoksazola i natrijevog valproata, nisu utjecale na vezanje docetaksela za proteine.
English: Tell your doctor, hospital pharmacist or nurse if you have heart problems.
Croatian: Obavijestite svog liječnika, bolničkog ljekarnika ili medicinsku sestru ako imate problema sa srcem.
English: What DOCETAXEL KABI looks like and contents of the pack DOCETAXEL KABI concentrate for solution for infusion is a clear, colourless to pale yellow solution.
Croatian: Kako DOCETAXEL KABI izgleda i sadržaj pakiranja DOCETAXEL KABI koncentrat za otopinu za infuziju je bistra, bezbojna do blijedo žuta otopina.
English: Frequencies are defined as: very common (≥ 1/10), common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000); not known (cannot be estimated from available data).
Croatian: Učestalosti su definirane kao: vrlo često (≥1/10). često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000), nepoznato (učestalost se ne može procijeniti iz dostupnih podataka).
English: Docetaxel every 3 weeks
Croatian: Docetaksel svaka 3 tjedna
English: • Time to progression (TTP) was significantly longer in the AT arm versus AC arm, p = 0.0138.
Croatian: • Vrijeme do progresije bolesti (engl. time to progression, TTP) bilo je značajno dulje u AT skupini u odnosu na AC skupinu, p=0,0138.
English: Rare cases of myocardial infarction have been reported.
Croatian: Rijetko su zabilježeni slučajevi infarkta miokarda.
English: Clearance of docetaxel in combination therapy with cisplatin was similar to that observed following monotherapy.
Croatian: Klirens docetaksela u kombiniranoj terapiji s cisplatinom bio je sličan onom nakon monoterapije.
English: G3/4 ALT increased
Croatian: G3/4 povećanje ALT
English: All patients who did not have progressive disease were to receive chemoradiotherapy (CRT) as per protocol (TPF/CRT).
Croatian: Svi bolesnici koji nisu imali progresiju bolesti, liječeni su kemoradioterapijom (CRT) prema protokolu (TPF/CRT).
English: In combination with capecitabine, for patients 60 years of age or more, a starting dose reduction of capecitabine to 75% is recommended (see capecitabine summary of product characteristics).
Croatian: U kombinaciji s kapecitabinom bolesnicima od 60 godina i starijima preporučuje se smanjiti početnu dozu kapecitabina na 75% (vidjeti sažetak opisa svojstava lijeka za kapecitabin).
English: Other medicines and DOCETAXEL KABI
Croatian: Drugi lijekovi i DOCETAXEL KABI
English: In addition, dexamethasone did not affect protein binding of docetaxel.
Croatian: Osim toga, deksametazon nije utjecao na vezanje docetaksela za proteine.
English: METHOD AND ROUTE(S) OF ADMINISTRATION Ready to add to infusion solution.
Croatian: NAČIN I PUT(EVI) PRIMJENE LIJEKA Spremno za dodavanje u infuzijsku otopinu.
English: Interruption of docetaxel therapy is recommended until diagnosis is available.
Croatian: Preporučuje se privremeni prekid terapije docetakselom do postavljanja dijagnoze.
English: For patients who experience complicated neutropenia (prolonged neutropenia, febrile neutropenia or infection), G-CSF and dose reduction should be considered (see section 4.2).
Croatian: Bolesnicima u kojih se pojavila komplicirana neutropenija (produljena neutropenija, febrilna neutropenija ili infekcija) treba razmotriti primjenu G-CSF i smanjenje doze (vidjeti dio 4.2.).
English: Neutropenic complications
Croatian: Neutropenijske komplikacije
English: More grade 3/4 adverse events were observed for docetaxel monotherapy (55.4%) compared to paclitaxel (23.0%).
Croatian: Više nuspojava stupnja 3/4 zabilježeno je u monoterapiji docetakselom (55,4%) u usporedbi s paklitakselom (23,0%).
English: In combination with cisplatin
Croatian: Kombinacija s cisplatinom
English: Scleroderma-like changes usually preceded by peripheral lymphoedema have been reported with docetaxel.
Croatian: Promjene slične sklerodermiji, kojima obično prethodi periferni limfedem, zabilježeni su s docetakselom.
English: Hypersensitivity reactions (frequency not known) have been reported with docetaxel in patients who previously experienced hypersensitivity reactions to paclitaxel.
Croatian: Reakcije preosjetljivosti (učestalost nije poznata) su prijavljene u bolesnika liječenih docetakselom koji su prethodno doživili reakcije preosjetljivosti na paklitaksel.
English: Patients with operable node-positive breast cancer (TAX 316)
Croatian: Bolesnici s operabilnim karcinomom dojke i pozitivnim limfnim čvorovima (TAX 316)
English: The kinetic profile of docetaxel is dose independent and consistent with a three-compartment pharmacokinetic model with half lives for the α, β and γ phases of 4 min, 36 min and 11.1 h, respectively.
Croatian: Kinetički profil docetaksela neovisan je o dozi i u skladu je s farmakokinetičkim modelom tri odjeljka, s poluvijekom za alfa, beta i gama fazu od 4 minute, 36 minuta i 11,1 sati.
English: Tumor response rate (%) 95% CI p-value* †Stratified log-rank test *Threshold for statistical significance = 0.0175 **PSA: Prostate-Specific Antigen
Croatian: Stopa tumorskog odgovora (%) 95% CI p-vrijednost* † Stratificirani log- rank test * prag statističke značajnosti = 0,0175 ** PSA: prostata specifični antigen
English: Women of childbearing potential/ Contraception in males and females Women of childbearing age receiving docetaxel should be advised to avoid becoming pregnant, and to inform the treating physician immediately should this occur.
Croatian: Žene reproduktivne dobi/Kontracepcija u muškaraca i žena Žene reproduktivne dobi koje primaju docetaksel treba savjetovati da izbjegavaju trudnoću te da odmah obavijeste svog liječnika ako zatrudne.