FrancophonIA/ELRC3.0 huggingface dataset:
English: You can drink water but no other drinks (see 3.
Slovenian: Lahko pijete vodo, drugih pijač pa ne (glejte 3.
English: Choose the date that best fits your routine.
Slovenian: Izberite dan, ki najbolje ustreza vaši rutini.
English: - If you can't stand or sit upright for at least one hour (60 minutes) at a time.
Slovenian: - Če ne morete stati ali pokončno sedeti vsaj eno uro (60 minut) skupaj.
English: You may be having an allergic reaction to the medicine
Slovenian: Morda imate alergično reakcijo na to zdravilo.
English: - Choose one day of the month that will be easy to remember.
Slovenian: - Izberite si dan v mesecu, ki si ga boste lahko zapomnili.
English: This information is intended for healthcare professionals only:
Slovenian: Naslednje informacije so namenjene samo zdravstvenemu osebju:
English: • Needles and syringes should never be reused.
Slovenian: • igle in injekcijske brizge se nikoli ne smejo uporabiti ponovno;
English: Instead, consult your calendar and find out when your next scheduled dose is:
Slovenian: Namesto tega poglejte v vaš koledar, kdaj je naslednji načrtovani odmerek:
English: • feeling tired and exhausted
Slovenian: • občutek utrujenosti in izčrpanosti.
English: Malta (See United Kingdom)
Slovenian: Malta (glejte Velika Britanija)
English: • Dispose of the full container according to local requirements or as instructed by your healthcare provider.
Slovenian: • poln zabojnik odstranite v skladu z lokalnimi predpisi ali kot vam je naročil zdravstveni delavec.
English: Use the peel-off stickers below to mark the dates on your calendar.
Slovenian: Uporabite spodnje nalepke, da si označite te datume na svojem koledarju.
English: A healthy lifestyle will also help you to get the most benefit from your treatment.
Slovenian: Zdrav način življenja vam bo prav tako pomagal, da bo vaše zdravljenje čimbolj uspešno.
English: There are few data available on patients of African origin.
Slovenian: Na voljo je zelo malo podatkov za bolnike afriškega porekla.
English: Please consult your doctor.
Slovenian: posvetujte se z zdravnikom.
English: Never take two Bondenza tablets within the same week.
Slovenian: Nikoli ne vzemite dveh tablet zdravila Bondenza v istem tednu.
English: Once you've eaten, it's OK to lie down if you wish, and to take any other medication you need.
Slovenian: Ko ste se najedli, se lahko uležete, če želite, in vzamete druga zdravila, ki jih potrebujete.
English: - After you've waited for an hour, you can have your first food and drink of the day.
Slovenian: - Potem, ko ste počakali eno uro, lahko zaužijete svoj prvi dnevni obrok.
English: • serious, potentially life-threatening allergic reaction
Slovenian: • resna, možno življenjsko ogrožujoča alergična reakcija.
English: The marketing authorisation holder shall submit PSURs for this product in accordance with the requirements set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal.
Slovenian: Imetnik dovoljenja za promet bo oddajal PSUR za to zdravilo v skladu z zahtevami, opisanimi v seznamu referenčnih datumov Unije (EURD seznamu), opredeljenem v členu 107c(7) Direktive 2001/83/ES in objavljenem na spletni strani Evropske agencije za zdravila.
English: - If you have heart problems and the doctor recommended to limit your daily fluid intake
Slovenian: - Če imate težave s srcem in vam je zdravnik omejil dnevni vnos tekočine.
English: INFORMATION IN BRAILLE [Justification for not including Braille accepted]
Slovenian: PODATKI V BRAILLOVI PISAVI [Sprejeta je utemeljitev, da Braillova pisava ni potrebna.]
English: Taking your monthly tablet
Slovenian: Mesečno jemanje vaše tablete
English: Month 1 __/__/__ 3 film-coated tablets Month 2 __/__/__ 3 film-coated tablets Month 3 __/__/__ 3 film-coated tablets Note down the date you take your tablet
Slovenian: 1. mesec __/__/__ 3 filmsko obložene tablete 2. mesec __/__/__ 3 filmsko obložene tablete 3. mesec __/__/__ 3 filmsko obložene tablete Zapišite si datum, ko boste vzeli tableto
English: Choose one day of the month that will be easy to remember: - either the same date (such as the 1st of each month) - or the same day (such as the first Sunday of each month).
Slovenian: Izberite en dan v mesecu, ki si ga boste najlaže zapomnili: - ali isti datum (npr. 1. v mesecu), - ali isti dan (npr. prvo nedeljo v mesecu).
English: If you develop these symptoms, stop taking Bondenza and tell your doctor straight away (see section 3).
Slovenian: Če se pri vas pojavijo ti simptomi, prenehajte jemati zdravilo Bondenza in takoj obvestite svojega zdravnika (glejte poglavje 3).
English: - Take your Bondenza tablet at least 6 hours after you last had anything to eat or drink except water.
Slovenian: - Vzemite tableto zdravila Bondenza vsaj 6 ur po tem, ko ste zadnjič karkoli pojedli ali pili karkoli razen vode.
English: The need for continued treatment should be re-evaluated periodically based on the benefits and potential risks of Bondenza on an individual patient basis, particularly after 5 or more years of use.
Slovenian: Potrebo po nadaljevanju zdravljenja z zdravilom Bondenza je treba periodično ponovno oceniti glede na koristi in tveganja za posameznega bolnika, še posebno po 5 letih ali več uporabe.
English: Do not take your tablet at bedtime or before you get up for the day.
Slovenian: Tablet ne jemljite zvečer ali preden zjutraj vstanete.
English: You should arrange an appointment to get the next injection as soon as possible.
Slovenian: Dogovoriti se morate za termin za naslednjo injekcijo takoj, ko je mogoče.
English: Bondenza is less effective if it's taken with food.
Slovenian: Zdravilo Bondenza je manj učinkovito, če ga jemljete skupaj s hrano.
English: • pain or injury at the injection site
Slovenian: • bolečina ali poškodba na mestu injiciranja,
English: Frequency categories are defined using the following convention: very common (>1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000) ,very rare (<1/10,000), not known (cannot be estimated from the available data).
Slovenian: Neželeni učinki so navedeni po organskih sistemih in pogostnosti po MedDRA. Glede na pogostnost so neželeni učinki opredeljeni kot zelo pogosti (≥1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), z neznano pogostnostjo (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti).
English: If you forget to take your tablet on the morning of your chosen day, do not take a tablet later in the day.
Slovenian: Če ste pozabili vzeti tableto na jutro izbranega dne, ne vzemite tablete pozneje v istem dnevu.
English: With no further dosing, there is a loss of suppression of biochemical markers of bone resorption.
Slovenian: Brez nadaljnjega odmerjanja pride do izgube supresije biokemičnih označevalcev resorpcije kosti.
English: Bondenza can treat osteoporosis only for as long as you keep receiving the treatment, even though you will not be able to see or feel a difference.
Slovenian: Zdravilo Bondenza lahko zdravi osteoporozo le, dokler nadaljujete z uporabo zdravila, čeprav ne boste videli ali čutili razlike.
English: A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE Name and address of the manufacturer responsible for batch release Film-coated tablet:
Slovenian: A. IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ Ime in naslov izdelovalca, odgovornega za sproščanje serij Filmsko obložene tablete:
English: What Bondenza is and what it is used for
Slovenian: Kaj je zdravilo Bondenza in za kaj ga uporabljamo
English: The most frequently reported adverse reactions were arthralgia and influenza-like symptoms.
Slovenian: Najpogosteje poročani neželeni učinki so bili artralgija in simptomi, podobni gripi.
English: You can choose either the same date (such as the 1st of each month) or the same day (such as the first Sunday of each month) to take your Bondenza tablet.
Slovenian: Lahko izberete ali isti datum (npr. 1. v mesecu) ali isti dan (npr. prvo nedeljo v mesecu) za jemanje tablet zdravila Bondenza.
English: Clinically meaningful reductions in serum CTX levels were observed at all time points measured, i.e. months 3, 6, 12 and 24.
Slovenian: Klinično pomembno zmanjšanje serumskih vrednosti CTX so opazili ob merjenju v vseh časovnih obdobjih, to je po 3, 6, 12 in 24 mesecih.
English: If you've taken more than one tablet by mistake, drink a full glass of milk and talk to your doctor straight away.
Slovenian: Če ste vzeli večji odmerek zdravila Bondenza, kot bi smeli Če ste po pomoti vzeli več kot eno tableto, popijte poln kozarec mleka in se takoj posvetujte s svojim zdravnikom.
English: Maximum observed plasma concentrations were reached within 0.5 to 2 hours (median 1 hour) in the fasted state and absolute bioavailability was about 0.6 %.
Slovenian: Najvišje plazemske koncentracije so bile med postom dosežene v času od 0,5 ure do 2 ur (mediana časa 1 ura), absolutna biološka uporabnost je bila okoli 0,6-%.
English: In a multivariate analysis, age was not found to be an independent factor of any of the pharmacokinetic parameters studied.
Slovenian: Multivariantna analiza je pokazala, da starost za vse preizkušane farmakokinetične parametre ni neodvisen dejavnik.
English: Bondenza belongs to a group of medicines called bisphosphonates.
Slovenian: Bondenza spada v skupino zdravil, ki jih imenujemo difosfonati.
English: - Tablets should be swallowed whole with a glass of water (180 to 240 ml) while the patient is sitting or standing in an upright position.
Slovenian: - Tablete je treba pogoltniti cele, s kozarcem vode (180 do 240 ml), bolnik mora pri tem stati ali pokončno sedeti.
English: Do not take your tablet with l water with a high concentration of calcium, fruit juice or any other drinks.
Slovenian: Tablete ne vzemite z vodo z visoko vsebnostjo kalcija, sadnim sokom ali katerokoli drugo pijačo.
English: In table 1 an overview of adverse reactions is presented.
Slovenian: V preglednici 1 je pregled neželenih učinkov.
English: It's important to keep taking Bondenza every month.
Slovenian: Pomembno je, da nadaljujete mesečno jemanje Bonvive.
English: Treatment of osteoporosis in postmenopausal women at increased risk of fracture (see section 5.1).
Slovenian: Zdravljenje osteoporoze pri postmenopavznih ženskah s povečanim tveganjem za zlome (glejte poglavje 5.1).
English: The safety profile of Bondenza is derived from controlled clinical trials and post-marketing experience .
Slovenian: Varnostni profil zdravila Bondenza izhaja iz kontroliranih kliničnih preskušanj in izkušenj po prihodu zdravila na trg.
English: Bondenza can treat osteoporosis only as long as you keep taking it.
Slovenian: Zdravilo Bondenza lahko zdravi osteoporozo le, dokler ga jemljete.
English: CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT 3 mg/3 ml
Slovenian: VSEBINA, IZRAŽENA Z MASO, PROSTORNINO ALI ŠTEVILOM ENOT 3 mg/3 ml
English: The MAH must ensure that the system of pharmacovigilance, presented in Module 1.8.1. of the Marketing Authorisation, is in place and functioning before and whilst the medicinal product is on the market.
Slovenian: Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da je sistem farmakovigilance predložen v modulu 1.8.1 dovoljenja za promet z zdravilom, vzpostavljen in deluje, preden da zdravilo v promet in ves čas trženja zdravila.
English: INFORMATION IN BRAILLE Bondenza 150 mg
Slovenian: PODATKI V BRAILLOVI PISAVI Bondenza 150 mg
English: Other medicines and Bondenza
Slovenian: Druga zdravila in zdravilo Bondenza
English: Bondenza was not studied in the paediatric population, therefore no efficacy or safety data are available for this patient population
Slovenian: Zdravila Bondenza pri pediatričnih bolnikih niso proučevali, zato za to skupino bolnikov ni na voljo podatkov o učinkovitosti in varnosti.
English: Following the third and fourth dose, the median maximum inhibition 6 days post dose was 74 % with reduction to a median inhibition of 56 % seen 28 days following the fourth dose.
Slovenian: Po tretjem in četrtem odmerku je bila mediana maksimalne inhibicije 6 dni po odmerku 74 % z zmanjšanjem na mediano inhibicije 56 % po 28 dneh po četrtem odmerku.
English: Once you've taken your tablet, put a tick in the box on the sticker.
Slovenian: Ko vzamete tableto, nalepko obkljukajte.
English: Date of latest renewal: 20.02.2009
Slovenian: Datum prve odobritve: 23.02.2004 Datum zadnjega podaljšanja: 20.02.2009
English: The tablet should preferably be taken on the same date each month.
Slovenian: Tableto je priporočeno vzeti na isti datum v mesecu.
English: If there is a concern regarding potentially high levels of calcium in the tap water (hard water), it is advised to use bottled water with a low mineral content.
Slovenian: Če obstaja skrb, da je v vodi iz pipe visok delež kalcija (trda voda), je priporočljivo uporabljati ustekleničeno vodo z nizko vsebnostjo mineralov.
English: Some patients need to be especially careful when using Bondenza.
Slovenian: Nekateri bolniki morajo biti pri prejemanju zdravila Bondenza še posebno previdni.
English: To get the most benefit from the treatment it is important to continue receiving the injections every 3 months for as long as your doctor prescribes it for you.
Slovenian: Za najboljši izkoristek zdravljenja je pomembno, da nadaljujete s prejemanjem zdravila Bondenza vsake 3 mesece, dokler vam je zdravljenje predpisal zdravnik.
English: • CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND
Slovenian: • POGOJI IN OMEJITVE V ZVEZI Z VARNO IN UČINKOVITO UPORABO ZDRAVILA
English: In case a dose is missed, patients should be instructed to take one Bondenza 150 mg tablet the morning after the tablet is remembered, unless the time to the next scheduled dose is within 7 days.
Slovenian: Če bolnik odmerek izpusti, mu je treba svetovati, naj vzame eno 150-mg tableto zdravila Bondenza naslednje jutro potem, ko se spomni, razen če je do naslednjega načrtovanega odmerka manj kot 7 dni.
English: - Supplements containing calcium, magnesium, iron or aluminium, as they could possibly influence the effects of Bondenza.
Slovenian: - Dodatke, ki vsebujejo kalcij, magnezij, železo ali aluminij, ker imajo lahko vpliv na delovanje zdravila Bondenza.
English: In some cases, these events did not resolve until the ibandronic acid was discontinued.
Slovenian: V nekaterih primerih ti dogodki niso prenehali dokler niso difosfonate ukinili.
English: Do not inject Bondenza yourself.
Slovenian: Zdravila Bondenza si ne injicirajte sami.
English: If you forget to take Bondenza
Slovenian: Če ste pozabili vzeti zdravilo Bondenza
English: Children and adolescents Do not give Bondenza to children or adolescents below 18 years.
Slovenian: Otroci in mladostniki Zdravila Bondenza ne dajajte otrokom in mladostnikom, mlajšim od 18 let.
English: Bisphosphonates (like Bondenza) may also do so.
Slovenian: Difosfonati (kot zdravilo Bondenza) imajo lahko enak učinek.
English: Do not take Bondenza if you're pregnant or breast feeding.
Slovenian: Ne jemljite zdravila Bondenza, če ste noseči ali dojite.
English: Do not suck, chew or crush tablets Read the package leaflet before use Once monthly tablet Oral use
Slovenian: Tablet ne sesajte, žvečite ali drobite Pred uporabo preberite priloženo navodilo mesečna tableta peroralna uporaba
English: Children and adolescents Bondenza must not be used in children or adolescents below 18 years.
Slovenian: Otroci in mladostniki Zdravila Bondenza se ne sme uporabljati pri otrocih ali mladostnikih, mlajših od 18 let.
English: It's important to keep taking Bondenza every month, as long as your doctor prescribes it for you.
Slovenian: Pomembno je, da vzamete zdravilo Bondenza vsak mesec, dokler vam ga je predpisal zdravnik.
English: What you need to know before you receive Bondenza
Slovenian: Kaj morate vedeti, preden boste prejeli zdravilo Bondenza
English: After swallowing your monthly Bondenza tablet, wait for 1 hour before taking any other medication, including indigestion tablets, calcium supplements, or vitamins.
Slovenian: Vsak mesec, ko pogoltnete tableto zdravila Bondenza, počakajte 1 uro preden zaužijete katerokoli drugo zdravilo, vključno z zdravili proti slabi prebavi, kalcijevimi dodatki ali vitamini.
English: • itching, swelling of your face, lips, tongue and throat, with difficulty breathing.
Slovenian: • srbenje, otekanje obraza, ustnic, jezika in žrela s težkim dihanjem,
English: Bondenza intravenous injection decreased levels of serum C-telopeptide of the alpha chain of Type I collagen (CTX) within 3 - 7 days of starting treatment and decreased levels of osteocalcin within 3 months.
Slovenian: Intravenske injekcije zdravila Bondenza so zmanjšale vrednosti serumskih C-telopeptidov alfa verige kolagena tipa I (CTX) v 3 do 7 dneh po začetku zdravljenja in vrednosti osteokalcina v 3 mesecih.
English: - Swallow your tablet whole - do not chew it, crush it or let it dissolve in your mouth.
Slovenian: - Tableto pogoltnite celo - ne žvečite in ne prelamljajte tablete ter ne pustite, da se raztopi v ustih.
English: Bondenza should not be used during pregnancy.
Slovenian: Zdravila Bondenza se med nosečnostjo ne sme uporabljati.
English: - Hypersensitivity to ibandronic acid or to any of the excipients listed in section 6.1 - Hypocalcaemia - Abnormalities of the oesophagus which delay oesophageal emptying such as stricture or achalasia - Inability to stand or sit upright for at least 60 minutes
Slovenian: - Preobčutljivost na ibandronsko kislino ali katero koli pomožno snov, navedeno v poglavju 6.1 - Hipokalcemija - Nenormalnosti požiralnika, ki podaljšajo praznjenje požiralnika, kot npr. striktura ali ahalazija - Nesposobnost stati ali pokončno sedeti vsaj 60 minut
English: Patients should then return to taking their dose once a month on their originally scheduled date.
Slovenian: Bolnik naj nadaljuje jemanje odmerka enkrat na mesec na prvotno izbrani dan.
English: Hypocalcaemia
Slovenian: Hipokalcemija
English: Please see the Summary of Product Characteristics for more information.
Slovenian: INFORMACIJE ZA ZDRAVSTVENO OSEBJE Prosimo, glejte Povzetek glavnih značilnosti zdravila za več informacij.
English: In healthy male volunteers and postmenopausal women, intravenous administration of ranitidine caused an increase in ibandronic acid bioavailability of about 20 %, probably as a result of reduced gastric acidity.
Slovenian: Pri zdravih moških prostovoljcih in ženskah v postmenopavzi je intravensko apliciran ranitidin zvečal biološko uporabnost ibandronske kisline za približno 20 %, kar je verjetno posledica zmanjšane kislosti želodca.
English: LIST OF EXCIPIENTS The tablets also contain lactose.
Slovenian: SEZNAM POMOŽNIH SNOVI Tablete vsebujejo tudi laktozo.
English: Marketing Authorisation Holder Roche Registration Limited 6 Falcon Way
Slovenian: Imetnik dovoljenja za promet z zdravilom Roche Registration Limited 6 Falcon Way
English: - Patients should not chew or suck the tablet, because of a potential for oropharyngeal ulceration.
Slovenian: - Bolniki tablet ne smejo žvečiti ali sesati, ker lahko pride do ulceracije žrela.
English: Patients should pay particular attention to and be able to comply with the dosing instructions (see section 4.2).
Slovenian: Bolniki morajo skrbno prebrati navodila za uporabo in jim biti sposobni slediti (glejte poglavje 4.2).
English: Irritation, inflammation or ulceration of the gullet/food pipe (oesophagus) often with symptoms of severe pain in the chest, severe pain after swallowing food and/or drink, severe nausea, or vomiting may occur, especially if you do not drink a full glass of water and/or if you lie down within an hour of taking Bondenza.
Slovenian: Lahko pride do draženja, vnetja ali razjede požiralnika, pogosto s simptomi, kot so huda bolečina v prsih, huda bolečina pri požiranju hrane in/ali pitju pijače, huda slabost ali bruhanje, še posebej, če ne popijete polnega kozarca vode in/ali če se uležete prej kot v eni uri po zaužitju zdravila Bondenza.
English: - Acetylsalicylic acid and other non-steroidal anti-inflammatory medicines (NSAIDs) (including ibuprofen, diclofenac sodium and naproxen) may irritate the stomach and intestine.
Slovenian: - Acetilsalicilno kislino in druga nesteroidna protivnetna zdravila (NSAID, ki vključujejo ibuprofen, natrijev diklofenak in naproksen) lahko dražijo želodec in črevesje.
English: On the basis of the pharmacodynamic and pharmacokinetic profile and reported adverse reactions, it is expected that Bondenza has no or negligible influence on the ability to drive and use machines.
Slovenian: Glede na farmakodinamske in farmakokinetične lastnosti ter poročane neželene učinke pričakujemo, da zdravilo Bondenza nima ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
English: The difference between the apparent total and renal clearances is considered to reflect the uptake by bone.
Slovenian: Razlika med navideznim celokupnim in ledvičnim očistkom kaže na prevzem v kostno tkivo.
English: - Hypersensitivity to ibandronic acid or to any of the excipients listed in section 6.1 - Hypocalcaemia
Slovenian: - Preobčutljivost na ibandronsko kislino ali katero koli pomožno snov, navedeno v poglavju 6.1 - Hipokalcemija
English: The strong effect on vertebral fractures was furthermore reflected by a statistically significant reduction of height loss compared to placebo (p<0.0001).
Slovenian: Močan vpliv na zlome vretenc se je kazal tudi s statistično značilno manjšo izgubo telesne višine v primerjavi s placebom (p < 0,0001).
English: These symptoms are typically in association with the first dose, generally of short duration, mild or moderate in intensity, and usually resolve during continuing treatment, without requiring remedial measures (please see paragraph “Influenza like illness”).
Slovenian: Ti simptomi so značilno povezani s prvim odmerkom, ponavadi so kratkotrajni, blagi do zmerno močni in ponavadi izginejo z nadaljevanjem zdravljenja brez posegov v samo zdravljenje (prosimo, glejte odstavek »Bolezen, podobna gripi«).
English: The risk of severe oesophageal adverse experiences appears to be greater in patients who do not comply with the dosing instruction and/or who continue to take oral bisphosphonates after developing symptoms suggestive of oesophageal irritation.
Slovenian: Tveganje za resne neželene učinke v požiralniku je večje pri bolnikih, ki se ne držijo navodil za uporabo in/ali ki peroralne difosfonate po pojavu simptomov draženja požiralnika jemljejo še naprej.
English: Care must be taken not to administer Bondenza injection via intra-arterial or paravenous administration as this could lead to tissue damage.
Slovenian: Potrebna je previdnost, da injekcije zdravila Bondenza ne damo intraarterijsko ali paravensko, ker lahko poškodujemo tkivo.
English: NAME OF THE MARKETING AUTHORISATION HOLDER Roche Registration Ltd.
Slovenian: IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM Roche Registration Ltd.
English: Renal clearance (about 60 mL/min in healthy postmenopausal females) accounts for 50-60 % of total clearance and is related to creatinine clearance.
Slovenian: Ledvični očistek (okoli 60 ml/min pri zdravih ženskah v postmenopavzi) znaša okoli 50 do 60 % celotnega očistka in je povezan s kreatininskim očistkom.
English: Paediatric population (see section 4.2 and section 5.1) There are no data on the use of Bondenza in these age groups.
Slovenian: Pediatrični bolniki (glejte poglavji 4.2 in 5.1) O uporabi zdravila Bondenza pri tej skupini bolnikov ni podatkov.
English: In humans, the apparent terminal volume of distribution is at least 90 l and the amount of dose reaching the bone is estimated to be 40-50 % of the circulating dose.
Slovenian: Pri ljudeh znaša navidezni končni volumen porazdelitve najmanj 90 l, količina odmerka, ki doseže kosti, je ocenjena na 40 do 50 % odmerka, ki je v krvnem obtoku.