FrancophonIA/ELRC3.0 huggingface dataset:
English: These results indicate that raltegravir is not an inducer or inhibitor of CYP3A4, and raltegravir is thus not anticipated to affect the pharmacokinetics of medicinal products which are CYP3A4 substrates.
Croatian: Ovi rezultati ukazuju da raltegravir nije ni induktor ni inhibitor CYP3A4 i stoga se ne očekuje da utječe na farmakokinetiku lijekova koji su supstrati CYP3A4.
English: Patients received either the 400 mg tablet formulation (6 to 18 years of age) or the chewable tablet formulation (2 to less than 12 years of age).
Croatian: Bolesnici su primali lijek ili u obliku tablete od 400 mg (u dobi od 6 do 18 godina) ili u obliku tablete za žvakanje (u dobi od 2 do manje od 12 godina).
English: However, the effect of raltegravir on darunavir plasma concentrations does not appear to be clinically meaningful.
Croatian: Međutim, učinak raltegravira na plazmatske koncentracije darunavira ne doima se klinički značajnim.
English: Lactic acidosis has a high mortality and may be associated with pancreatitis, liver failure, or renal
Croatian: Laktacidoza ima visoku smrtnost, a može biti udružena s pankreatitisom, zatajenjem jetre ili
English: This may mean that the HIV virus will develop resistance to DUTREBIS and become harder to treat.
Croatian: To može značiti da je virus HIV-a postao otporan na DUTREBIS i postaje ga teže liječiti.
English: Therapy should be initiated by a physician experienced in the management of HIV infection.
Croatian: Terapiju mora započeti liječnik s iskustvom u liječenju HIV infekcije.
English: Based on modelling and simulation using raltegravir pharmacokinetic data in adults, the pharmacokinetics of raltegravir in DUTREBIS in children was projected to result in exposures that have been previously shown to be safe and efficacious in adults.
Croatian: Na temelju modeliranja i simulacije farmakokinetičkih podataka raltegravira u odraslih, projicirana farmakokinetika raltegravira, kao komponente lijeka DUTREBIS, u djece rezultira razinama izloženosti za koje je prethodno dokazano da su sigurne i djelotvorne u odraslih.
English: As the in vitro mutagenic activity of lamivudine could not be confirmed in in vivo tests, it is concluded that lamivudine should not represent a genotoxic hazard to patients undergoing
Croatian: Budući da se mutagena aktivnost lamivudina in vitro nije mogla potvrditi testovima in vivo, zaključeno je da lamivudin ne bi trebao predstavljati genotoksični rizik za bolesnika koji se liječi.
English: In vitro studies indicate that raltegravir is not a substrate of cytochrome P450 (CYP) enzymes, does not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP3A, does not induce CYP3A4 and does not inhibit P-glycoprotein-mediated transport.
Croatian: Istraživanja in vitro ukazuju da raltegravir nije supstrat enzima citokroma P450 (CYP), ne inhibira CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 ni CYP3A, ne inducira CYP3A4 niti inhibira transport posredovan P-glikoproteinom.
English: With twice-daily dosing of raltegravir, pharmacokinetic steady state is achieved rapidly, within approximately the first 2 days of dosing.
Croatian: Primjenom raltegravira dvaput na dan farmakokinetičko stanje dinamičke ravnoteže postiže se brzo, priblližno unutar prva 2 dana primjene.
English: Lamivudine is also available as an oral solution for children over three months of age and who weigh less than 14 kg or for patients who are unable to swallow tablets.
Croatian: Lamivudin je dostupan i u obliku oralne otopine za djecu stariju od 3 mjeseca i tjelesne težine manje od 14 kg ili za bolesnike koji ne mogu progutati tablete.
English: In interaction studies, raltegravir did not have a clinically meaningful effect on the pharmacokinetics of etravirine, maraviroc, tenofovir, hormonal contraceptives, methadone, midazolam, or boceprevir.
Croatian: U ispitivanjima interakcija raltegravir nije imao klinički značajan učinak na farmakokinetiku etravirina, maraviroka, tenofovira, hormonskih kontraceptiva, metadona, midazolama ili boceprevira.
English: The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when the main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim.
Croatian: Treba uzeti u obzir mogućnost interakcija s drugim istodobno primijenjenim lijekovima, osobito ako je njihov glavni put eliminacije aktivna bubrežna sekrecija uz pomoć sustava organskih kationskih prijenosnika, npr. trimetoprimom.
English: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this
Croatian: Bolesnici s rijetkim nasljednim poremećajima nepodnošenja galaktoze, nedostatkom Lapp laktaze ili glukoza-galaktoza malapsorpcijom ne smiju
English: • allergic rash (including red spots or blotches sometimes with blistering and swelling of
Croatian: • alergijski osip (uključujući crvene točkice ili mrlje, ponekad praćene mjehurićima na koži
English: Lactic acidosis is caused by a build-up of lactic acid in the body.
Croatian: Laktacidozu uzrokuje nakupljanje mliječne kiseline u tijelu.
English: The active moiety, intracellular lamivudine triphosphate, has a prolonged terminal half-life in the cell (16 to 19 hours) compared to the plasma lamivudine half-life (5 to 7 hours).
Croatian: Aktivni oblik, unutarstanični lamivudin trifosfat, ima produljeni poluvijek u stanici (16 do 19 sati) u usporedbi s poluvijekom lamivudina u plazmi (5 do 7 sati).
English: • medicines containing lamivudine - used to treat HIV or hepatitis B.
Croatian: • lijekove koji sadrže lamivudin - koriste se za liječenje HIV-a ili hepatitisa B.
English: • When your supply of DUTREBIS starts to run low, get more from your doctor or pharmacy.
Croatian: • Kada se Vaša zaliha lijeka DUTREBIS približi kraju, nabavite novu količinu od svog liječnika ili ljekarnika.
English: • feeling anxious; feeling of confusion; depressed mood; mood changes; panic attack
Croatian: • osjećaj tjeskobe; osjećaj smetenosti; depresivno raspoloženje; promjene raspoloženja;
English: Some patients taking combination treatment for HIV may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Croatian: U nekih bolesnika koji uzimaju kombiniranu terapiju za HIV može se razviti bolest kostiju koja se zove osteonekroza (propadanje koštanog tkiva zbog prestanka opskrbe kosti krvlju).
English: Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) which has activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Croatian: Lamivudin je nukleozidni inhibitor reverzne transkriptaze (NRTI) koji djeluje protiv virusa humane imunodeficijencije (HIV) i virusa hepatitisa B (HBV).
English: Your doctor has prescribed DUTREBIS to help control your HIV infection.
Croatian: Liječnik Vam je propisao DUTREBIS kako bi Vam pomogao držati HIV infekciju pod kontrolom.
English: IMPAACT P1066 is a Phase I/II open label multicentre study to evaluate the pharmacokinetic profile, safety, tolerability, and efficacy of raltegravir in HIV infected children.
Croatian: IMPAACT P1066 je otvoreno multicentrično ispitivanje faze I/II u kojem se ispituje farmakokinetički profil, sigurnost, podnošljivost i djelotvornost raltegravira u djece inficirane HIV-om.
English: • increased levels of lactic acid in the blood, which on rare occasions can lead to lactic acidosis; increased levels of sugar and fats (triglycerides and cholesterol) in the blood; resistance to insulin (so if you are diabetic, you may have to change your insulin dose to control your blood sugar).
Croatian: • povišene razine mliječne kiseline u krvi, što u rijetkim slučajevima može dovesti do laktacidoze; povišene razine šećera i masnoća (triglicerida i kolesterola) u krvi; rezistencija (otpornost) na inzulin (tako da ćete, ako imate šećernu bolest, možda morati promijeniti dozu inzulina kojom kontrolirate razinu šećera u krvi).
English: DUTREBIS film-coated tablets contain lactose If you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor
Croatian: DUTREBIS filmom obložene tablete sadrže laktozu Ako Vam je liječnik rekao da ne podnosite neke šećere, savjetujte se s liječnikom prije uzimanja ovog
English: The M184V RT mutant shows a <4-fold decrease in susceptibility to didanosine; the clinical significance of these findings is unknown.
Croatian: Reverzna transkriptaza s mutacijom M184V pokazuje < četverostrukog smanjenja osjetljivosti na didanozin; kliničko značenje tog nalaza nije poznato.
English: Safety and efficacy of lamivudine have not been established in the presence of decompensated liver disease.
Croatian: Nisu utvrđene sigurnost i djelotvornost lamivudina u prisutnosti dekompenzirane bolesti jetre.
English: Limited data show that lamivudine penetrates the central nervous system and reaches the cerebrospinal fluid (CSF).
Croatian: Ograničeni podaci pokazuju da lamivudin prolazi u središnji živčani sustav i ulazi u cerebrospinalnu tekućinu.
English: Do not stop taking DUTREBIS without your doctor's advice.
Croatian: Nemojte prestati uzimati DUTREBIS ako se o tome prethodno niste posavjetovali sa svojim liječnikom.
English: Overall, the results of the clinical pharmacology studies with DUTREBIS demonstrate similar drug exposures compared to the individual components of lamivudine and raltegravir, including similar variability in raltegravir C12hr and Cmax.
Croatian: Općenito, rezultati kliničkih farmakoloških ispitivanja lijeka DUTREBIS ukazuju na sličnu izloženost lijeku kao i pri primjeni njegovih pojedinačnih komponenti lamivudina i raltegravira, uključujući sličnu varijabilnost C12h i Cmax raltegravira.
English: If you notice within 6 hours, you must take the tablet immediately.
Croatian: Ako je od propuštanja doze prošlo manje od 6 sati, tabletu morate uzeti odmah.
English: Zidovudine and stavudine maintain their antiretroviral activities against lamivudine-resistant HIV-1.
Croatian: Zidovudin i stavudin održavaju antiretrovirusnu aktivnost protiv HIV-1 rezistentnih na lamivudin.
English: 48 Weeks
Croatian: 48 tjedana
English: Lamivudine metabolism does not involve CYP3A, making interactions with medicinal products metabolised by this system (e.g. PIs) unlikely.
Croatian: Metabolizam lamivudina ne uključuje CYP3A, što znači da nisu vjerojatne interakcije s lijekovima koji se metaboliziraju putem tog sustava (npr. inhibitori proteaze).
English: At the highest dose levels, 400 mg/kg/day in females and 250 mg/kg/day in males, systemic exposure was similar to that at the clinical dose of 400 mg twice daily.
Croatian: Pri najvišoj dozi od 400 mg/kg/dan kod ženki i 250 mg/kg/dan kod mužjaka, sustavna izloženost bila je slična onoj koja se postiže pri kliničkoj dozi od 400 mg dvaput na dan.
English: Abacavir maintains its antiretroviral activities against lamivudine resistant HIV-1 harbouring only the M184V mutation.
Croatian: Abakavir održava antiretrovirusnu aktivnost protiv HIV-1 rezistentnih na lamivudin koji nose samo mutaciju M184V.
English: Dose selection was based upon achieving similar raltegravir plasma exposure and trough concentration as seen in adults, and acceptable short term safety.
Croatian: Odabir doze temeljio se na postizanju slične izloženosti raltegraviru u plazmi i najniže koncentracije lijeka kao u odraslih te na prihvatljivoj kratkoročnoj sigurnosti.
English: Clinical end-point data indicate that lamivudine in combination with zidovudine, results in a significant reduction in the risk of disease progression and mortality.
Croatian: Podaci o kliničkim ishodima ukazuju da lamivudin u kombinaciji sa zidovudinom značajno smanjuje rizik od progresije bolesti i smrtnosti.
English: In the event of an overdose, it is reasonable to employ the standard supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy if required.
Croatian: U slučaju predoziranja uputno je primijeniti uobičajene suportivne mjere, npr. uklanjanje neapsorbiranog lijeka iz gastrointestinalnog trakta, praćenje bolesnikova kliničkog stanja (uključujući i EKG) te po potrebi uvođenje suportivne terapije.
English: As a general rule, when deciding to use anti-retroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account in order to characterise the safety for the foetus.
Croatian: Općenito je pravilo, kada se odlučuje o primjeni antiretrovirusnih lijekova za liječenje HIV infekcije u trudnica te, posljedično, za smanjenje rizika od vertikalnog prijenosa HIV-a na novorođenče, da se moraju uzeti u obzir podaci iz istraživanja na životinjama, kao i kliničko iskustvo primjene u trudnica kako bi se mogla odrediti sigurnost za fetus.
English: Lipid disorders should be managed as clinically appropriate (see section 4.8).
Croatian: Poremećaje lipida treba liječiti sukladno kliničkoj potrebi (vidjeti dio 4.8).
English: In two studies of HIV-1 infected patients who received raltegravir 400 mg twice daily, raltegravir was readily detected in the cerebrospinal fluid.
Croatian: U dva ispitivanja u bolesnika inficiranih virusom HIV-1 koji su primali raltegravir u dozi od 400 mg, dvaput na dan, raltegravir je detektiran u cerebrospinalnoj tekućini.
English: Patients receiving lamivudine or any other ART may continue to develop opportunistic infections and other complications of HIV infection, and therefore should remain under close clinical observation by physicians experienced in the treatment of patients with associated HIV diseases.
Croatian: U bolesnika koji primaju lamivudin ili bilo koji drugi ART i dalje se mogu javljati oportunističke infekcije i druge komplikacije povezane s HIV infekcijom te takvi bolesnici stoga moraju ostati pod pomnim kliničkim nadzorom liječnika s iskustvom u liječenju bolesti povezanih s HIV-om.
English: As a general rule, it is recommended that mothers infected by HIV do not breast-feed their babies in order to avoid transmission of HIV.
Croatian: Općenito se ne preporučuje da majke inficirane HIV-om doje svoju djecu kako bi se izbjegao prijenos HIV-a.
English: In vitro lamivudine inhibits the intracellular phosphorylation of cladribine leading to a potential risk of cladribine loss of efficacy in case of combination in the clinical setting.
Croatian: In vitro lamivudin inhibira unutarstaničnu fosforilaciju kladribina, što dovodi do potencijalnog rizika od gubitka djelotvornosti kladribina u slučaju kombinirane primjene u kliničkim uvjetima.
English: Raltegravir is also available in a chewable tablet formulation for children weighing at least 11 kg and in granules for oral suspension formulation for infants and toddlers from 4 weeks of age and weighing at least 3 kg to less than 20 kg.
Croatian: Raltegravir je dostupan i u obliku tableta za žvakanje za djecu tjelesne težine najmanje 11 kg te u obliku granula za oralnu suspenziju za dojenčad i malu djecu od navršena 4 tjedna života i tjelesne težine od najmanje 3 kg do manje od 20 kg.
English: The mean systemic clearance of lamivudine is approximately 0.32 l/h/kg, with predominantly renal clearance (> 70 %) via the organic cationic transport system.
Croatian: Srednja vrijednost sistemskog klirensa lamivudina je približno 0,32 l/h/kg, pretežno bubrežnim klirensom (> 70%) putem sustava organskih
English: Lamivudine has no effect on the pharmacokinetics of trimethoprim or sulfamethoxazole.
Croatian: Lamivudin ne utječe na farmakokinetiku trimetoprima ni sulfametoksazola.
English: • blood test showing failure of the bone marrow to produce new red blood cells (pure red cell aplasia)
Croatian: • nalazi krvnih pretraga koji ukazuju na zatajenje koštane srži u stvaranju novih crvenih krvnih stanica (aplazija crvenih krvnih stanica).
English: Consideration should be given to the measurement of fasting serum lipids and blood glucose.
Croatian: Treba razmotriti mjerenje lipida u serumu i glukoze u krvi natašte.
English: ≤ 100,000 copies/ml CD4-count ≤ 50 cells/mm > 50 and
Croatian: ≤ 100 000 kopija/ml Broj CD4 stanica ≤ 50 stanica/mm > 50 i
English: Safety profiles in the subgroup of patients in Phase III studies taking proton pump inhibitors or H2 antagonists were comparable with those who were not taking these antacids.
Croatian: Sigurnosni profili u podskupini bolesnika koji su u ispitivanjima faze III uzimali inhibitore protonske pumpe ili antagoniste H2 receptora bili su usporedivi s onima u bolesnika koji nisu uzimali navedene antacide.
English: If you take more DUTREBIS than you should Do not take more tablets than the doctor recommends.
Croatian: Nemojte uzeti više tableta nego što je preporučio liječnik.
English: Patients had prior exposure to a median of 12 anti-retrovirals for a median of 10 years.
Croatian: Bolesnici su prethodno liječeni s 12 antiretrovirusnih lijekova (medijan) u trajanju od 10 godina (medijan).
English: DUTREBIS is used in combination with other medicines to treat adults, adolescents, and children 6 years of age and older and weighing at least 30 kg who are infected by HIV.
Croatian: DUTREBIS se koristi u kombinaciji s drugim lijekovima za liječenje HIV infekcije u odraslih, adolescenata i djece u dobi od 6 godina i starijih i tjelesne težine najmanje 30 kg.
English: In clinical studies, lamivudine in combination with zidovudine has been shown to reduce HIV-1 viral load and increase CD4 cell count.
Croatian: U kliničkim ispitivanjima lamivudin je u kombinaciji sa zidovudinom smanjio virusno opterećenje HIV-1 i povećao broj CD4 stanica.
English: DUTREBIS should not be taken with any other medicinal products containing lamivudine, raltegravir or medicinal products containing emtricitabine.
Croatian: DUTREBIS se ne smije uzimati niti s jednim drugim lijekom koji sadrži lamivudin ili raltegravir niti s lijekovima koji sadrže emtricitabin.
English: Interaction (mechanism, if known)
Croatian: Lijekovi po terapijskim područjima Interakcija (mehanizam, ako je poznat)
English: HIV-RNA > 100,000 copies/ml
Croatian: HIV-RNK > 100 000 kopija/ml
English: In a single-cycle infection assay, raltegravir inhibited infection of 23 HIV isolates representing 5 non-B subtypes and 5 circulating recombinant forms with IC50 values ranging from 5 to 12 nM.
Croatian: Prilikom testiranja jednog ciklusa infekcije raltegravir je inhibirao infekciju 23 izolata HIV-a koji su predstavljali 5 podtipova virusa koji nisu skupine B i 5 cirkulirajućih rekombinantnih oblika, s vrijednostima IC50 u rasponu od 5 do 12 nM.
English: The impact of other strong inducers of drug metabolizing enzymes, such as phenytoin and phenobarbital, on UGT1A1 is unknown.
Croatian: Nije poznat utjecaj drugih snažnih induktora enzima metabolizma lijekova, poput fenitoina i fenobarbitala, na UGT1A1.
English: The apparent terminal half-life of raltegravir is approximately 9 hours, with a shorter α-phase half-life (~1 hour) accounting for much of the AUC.
Croatian: Prividan poluvijek raltegravira je oko 9 sati, s kraćim poluvijekom alfa faze (~1 sat) koja sačinjava veći dio AUC-a.
English: In the first study (n=18), the median cerebrospinal fluid concentration was 5.8 % (range 1 to 53.5 %) of the corresponding plasma concentration.
Croatian: U prvom ispitivanju (n=18) medijan koncentracije u cerebrospinalnoj tekućini iznosio je 5,8% (raspon od 1 do 53,5%) odgovarajuće koncentracije u plazmi.
English: However, raltegravir is secreted in the milk of lactating rats.
Croatian: Međutim, raltegravir se izlučuje u mlijeko štakorica u laktaciji.
English: Additional side effects in children and adolescents • hyperactivity
Croatian: Dodatne nuspojave u djece i adolescenata
English: Rifampicin may decrease your levels of raltegravir (one of the medicines in DUTREBIS).
Croatian: Rifampicin može sniziti koncentraciju raltegravira (jedan od lijekova koje DUTREBIS sadrži).
English: Possible interaction between lamivudine and cladribine due to inhibition of intracellular phosphorylation of cladribine by lamivudine.
Croatian: Moguća je interakcija između lamivudina i kladribina zbog inhibicije unutarstanične fosforilacije kladribina lamivudinom.
English: Dosing in children less than 6 years of age and those weighting less than 30 kg requires weight based dose adjustments for the individual components of DUTREBIS.
Croatian: Doziranje u djece mlađe od 6 godina i one tjelesne težine manje od 30 kg zahtijeva prilagođavanje doze pojedinačnih komponenti lijeka DUTREBIS na temelju tjelesne težine.
English: The comparative bioavailability of DUTREBIS (150 mg lamivudine/300 mg raltegravir) fixed-dose combination tablet was assessed relative to individual components administered concomitantly (150 mg of lamivudine and 400 mg of raltegravir) in 108 healthy subjects.
Croatian: Usporedna bioraspoloživost DUTREBIS tablete s fiksnom kombinacijom doza (150 mg lamivudina/300 mg raltegravira) ocijenjena je u odnosu na pojedinačne komponente primijenjene istodobno (150 mg lamivudina i 400 mg raltegravira) u 108 zdravih ispitanika.
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited binding to the major plasma protein albumin (< 16 % - 36 % to serum albumin in in vitro studies).
Croatian: U terapijskom rasponu doza, lamivudin ima linearnu farmakokinetiku i slabo se veže za albumin, glavni protein u plazmi (<16 % - 36% za serumski albumin u ispitivanjima in vitro).
English: Raltegravir400 mg twice daily + OBT (N = 462)
Croatian: Raltegravir 400 mg dvaput na dan + OBT (N=462)
English: Studies using isoform-selective chemical inhibitors and cDNA-expressed UDP-glucuronosyltransferases (UGT) show that UGT1A1 is the main enzyme responsible for the formation of raltegravir-glucuronide.
Croatian: Ispitivanja sa selektivnim kemijskim inhibitorima izoformi i UDP-glukuronoziltransferazama (UGT) koje eksprimira cDNK pokazala su da je UGT1A1 glavni enzim odgovoran za stvaranje raltegravir-glukuronida.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system
Croatian: Od zdravstvenih djelatnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava navedenog u Dodatku V.
English: • interferons taken with or without ribavirin - used to treat hepatitis.
Croatian: • interferone s ribavirinom ili bez njega - koriste se za liječenje hepatitisa.
English: Tell your doctor, pharmacist or nurse immediately if you notice any symptoms of infection or other symptoms such as:
Croatian: Odmah obavijestite svog liječnika, ljekarnika ili medicinsku sestru ako primijetite bilo koji simptom infekcije ili druge simptome poput:
English: DUTREBIS should not be co-administered with rifampicin due to reduced plasma concentrations of raltegravir (see section 4.5); the impact on the efficacy of raltegravir is unknown.
Croatian: DUTREBIS se ne smije primjenjivati s rifampicinom jer dolazi do sniženja koncentracija raltegravira u plazmi (vidjeti dio 4.5); utjecaj na djelotvornost raltegravira nije poznat.
English: Given that raltegravir is metabolised primarily via UGT1A1, caution should also be used when co-administering DUTREBIS with other strong inducers of UGT1A1.
Croatian: Budući da se raltegravir metabolizira primarno putem UGT1A1, oprez je potreban i kada se DUTREBIS primjenjuje istodobno s drugim snažnim induktorima UGT1A1.
English: Lamivudine has been widely used as a component of antiretroviral combination therapy with other antiretroviral agents of the same class (NRTIs) or different classes (PIs, non-nucleoside reverse transcriptase inhibitors, integrase inhibitors).
Croatian: Lamivudin se široko primjenjuje kao dio kombinirane antiretrovirusne terapije zajedno s drugim antiretrovirusnim lijekovima iste skupine (NRTI) ili drugih skupina (IP, nenukleozidni inhibitori reverzne transkriptaze, inhibitori integraze).