FrancophonIA/ELRC3.0 huggingface dataset:
English: ALT increased; AST increased; gamma glutamyl transferase increased
Danish: ALAT forhøjet, ASAT forhøjet, gamma-glutamyltransferase forhøjet
English: 21 tablets 42 tablets) 90 tablets 180 tablets
Danish: 21 tabletter 42 tabletter 90 tabletter 180 tabletter
English: Esbriet helps to reduce scarring and swelling in the lungs, and helps you breathe better.
Danish: Esbriet hjælper med at mindske ardannelsen og hævelsen i lungerne og hjælper dig med at trække vejret bedre.
English: The capsules contain a white to pale yellow powder.
Danish: Kapslerne indeholder et hvidt til svagt lysegult pulver.
English: The active substance is pirfenidone.
Danish: Aktivt stof: pirfenidon.
English: Pirfenidone attenuates fibroblast proliferation, production of fibrosis-associated proteins and cytokines, and the increased biosynthesis and accumulation of extracellular matrix in response to cytokine growth factors such as, transforming growth factor-beta (TGF-β) and platelet-derived growth factor (PDGF).
Danish: Pirfenidon svækker fibroblastproliferation, produktion af fibroseassocierede proteiner og cytokiner og øget biosyntese og akkumulation af ekstracellulær matrix som er en reaktion på cytokinvækstfaktor som f.eks. transformerende vækstfaktor beta (TGF-β) og trombocytderiveret vækstfaktor (PDGF).
English: Fluvoxamine should be discontinued prior to the initiation of Esbriet therapy and avoided during Esbriet therapy due to the reduced clearance of pirfenidone.
Danish: Fluvoxamin bør seponeres før initiering af Esbriet-behandling og undgås under Esbriet-behandling på grund af den nedsatte clearance af pirfenidon.
English: Administration of Esbriet capsules with food results in a large reduction in Cmax (by 50%) and a smaller effect on AUC, compared to the fasted state.
Danish: Administration af Esbriet kapsler med føde resulterer i en stor reduktion i Cmax (50 %) og en mindre virkning på AUC sammenlignet med fastende tilstand.
English: Population pharmacokinetic analyses from 4 studies in healthy subjects or subjects with renal impairment and one study in patients with IPF showed no clinically relevant effect of age, gender or body size on the pharmacokinetics of pirfenidone.
Danish: Farmakokinetiske populationsanalyser fra fire studier af raske forsøgspersoner eller forsøgspersoner med nedsat nyrefunktion og et studie med patienter med IPF viste ingen klinisk relevant indvirkning af alder, køn eller kropsstørrelse på pirfenidons farmakokinetik.
English: 2-week treatment initiation pack
Danish: 2-ugers pakning til initiering af behandling
English: NAME OF THE MARKETING AUTHORISATION HOLDER Roche Registration GmbH.
Danish: NAVN PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN Roche Registration GmbH.
English: Myalgia; arthralgia
Danish: Myalgi, artralgi
English: Esbriet should be used with caution when ciprofloxacin is used at a dose of 250 mg or 500 mg once or two times a day.
Danish: Esbriet bør anvendes med forsigtighed, når der anvendes en ciprofloxacindosis på 250 eller 500 mg én eller to gange om dagen.
English: If dizziness does not improve or if it worsens in severity, dose adjustment or even discontinuation of Esbriet may be warranted.
Danish: Hvis svimmelheden ikke forbedres, eller hvis den forværres, kan dosisjustering eller endog seponering af Esbriet være påkrævet.
English: Asthenia; non-cardiac chest pain Injury poisoning and procedural complications Common
Danish: Asteni, ikke-kardielle brystsmerter Traumer, forgiftninger og behandlingskomplikationer Almindelig
English: The MAH must ensure that at launch all physicians who are expected to prescribe Esbriet are provided with a physician information pack containing the following:
Danish: Indehaveren af markedsføringstilladelsen skal ved lanceringen sikre, at alle læger, der forventes at ordinere Esbriet, får udleveret en informationspakke til læger med følgende indhold:
English: A Phase 1 interaction study evaluated the effect of cigarette smoking (CYP1A2 inducer) on the pharmacokinetics of pirfenidone.
Danish: Et fase I-interaktionsstudie evaluerede virkningen af rygning (CYP1A2-induktor) på pirfenidons farmakokinetik.
English: The majority of pirfenidone is excreted as the 5-carboxy-pirfenidone metabolite (>95% of that recovered), with less than 1% of pirfenidone excreted unchanged in urine.
Danish: Størstedelen af pirfenidon udskilles som 5-carboxy-pirfenidon-metabolit (>95 % af den genfundne dosis), og mindre end 1 % pirfenidon udskilles uændret i urinen.
English: What Esbriet contains
Danish: Esbriet indeholder:
English: Exposure to 5-carboxy-pirfenidone increases 3.5 fold or more in patients with moderate renal impairment.
Danish: Eksponering for 5-carboxy-pirfenidon øges 3,5 gange eller mere hos patienter med moderat nedsat nyrefunktion.
English: Angioedema/Anaphylaxis
Danish: Angioødem/Anafylaksi
English: The parent substance is predominantly metabolised to 5-carboxy-pirfenidone.
Danish: Moderstoffet metaboliseres hovedsageligt til 5-carboxy-pirfenidon.
English: Hepatic function: In the event of significant elevation of alanine and/or aspartate aminotransferases (ALT/AST) with or without bilirubin elevation, the dose of pirfenidone should be adjusted or treatment discontinued according to the guidelines listed in section 4.4.
Danish: Leverfunktion: I tilfælde af en signifikant forhøjelse af alanin- og/eller aspartat-aminotransferaser (ALAT/ASAT) med eller uden forhøjet bilirubin bør dosis af pirfenidon justeres, eller behandlingen afbrydes i overensstemmelse med retningslinjerne i pkt.
English: 250 ml white HDPE bottle with child-resistant closure containing 270 capsules.
Danish: 250 ml hvid HDPE-beholder med børnesikret låg med 270 kapsler.
English: IPF is a chronic fibrotic and inflammatory pulmonary disease affected by the synthesis and release of pro-inflammatory cytokines including tumour necrosis factor-alpha (TNF-α) and interleukin-1-beta
Danish: IPF er en kronisk fibrotisk og inflammatorisk lungesygdom, som påvirkes af syntese og frigivelse af proinflammatoriske cytokiner, herunder tumornekrosefaktor alfa (TNF-α) og interleukin-1-beta (IL
English: The dose of pirfenidone may be reduced to 3 capsules/day (1 capsule three times a day).
Danish: Dosis af pirfenidon kan sættes ned til tre kapsler/dag (én kapsel tre gange dagligt).
English: When tested under UV exposure pirfenidone was positive in a photoclastogenic assay in Chinese hamster lung cells.
Danish: Når pirfenidon blev testet under UVeksponering, var det positivt i en fotoklastogen analyse på kinesiske hamster-lungeceller.
English: If you stop taking Esbriet
Danish: Hvis du holder op med at tage Esbriet
English: 4-week treatment maintenance pack
Danish: 4-ugers pakning til vedligeholdelse af behandling
English: ● Esbriet may cause dizziness and tiredness.
Danish: · Esbriet kan give svimmelhed og træthed.
English: SPECIAL STORAGE CONDITIONS Do not store above 30°C.
Danish: SÆRLIGE OPBEVARINGSBETINGELSER Må ikke opbevares ved temperaturer over 30 °C
English: Liver function tests (ALT, AST and bilirubin) should be conducted prior to the initiation of treatment with Esbriet, and subsequently at monthly intervals for the first 6 months and then every 3 months thereafter (see section 4.8).
Danish: Der bør udføres leverfunktionstest (ALAT, ASAT og bilirubin) før initiering af behandling med Esbriet og derefter hver måned i de første seks måneder og derefter hver tredje måned (se pkt.
English: A decision must be made whether to discontinue breast-feeding or to discontinue from Esbriet therapy, taking into account the benefit of breast-feeding for the child and the benefit of Esbriet therapy for the mother.
Danish: Det skal besluttes, om amning skal ophøre eller behandling med Esbriet seponeres, idet der tages højde for fordelene ved amning for barnet i forhold til de terapeutiske fordele for moderen.
English: 4 years for blisters.
Danish: 4 år for blister.
English: Date of latest renewal: 08 September 2015
Danish: Dato for første markedsføringstilladelse: 28. februar 2011 Dato for seneste fornyelse: 08. september 2015
English: If clinically appropriate the dose of Esbriet should be reduced or interrupted.
Danish: Hvis det skønnes klinisk påkrævet, bør dosis af Esbriet sættes ned eller afbrydes.
English: Patients with angioedema or severe allergic reactions should be managed according to standard of care.
Danish: Patienter med angioødem eller allergiske reaktioner af svær grad skal behandles efter gældende standarder.
English: ● Patients should be informed that Esbriet is known to be associated with photosensitivity reactions and that preventative measures have to be taken.
Danish: Lysfølsomhed · Patienter skal oplyses om, at Esbriet er forbundet med lysfølsomhedsreaktioner, og at der skal træffes forebyggende foranstaltninger.
English: Clinically relevant pharmacodynamic activity of the metabolite in patients with moderate renal impairment cannot be excluded.
Danish: Klinisk relevant farmakodynamisk aktivitet af metabolitten kan ikke udelukkes hos patienter med moderat nedsat nyrefunktion.
English: ● You should tell your doctor if you suffer from mild to moderate liver problems.
Danish: · Fortæl det til lægen, hvis du lider af milde til moderate leverproblemer.
English: Consumption of grapefruit juice is associated with inhibition of CYP1A2 and should be avoided during treatment with pirfenidone.
Danish: Indtagelse af grapefrugtjuice associeres med hæmning af CYP1A2 og bør undgås under behandling med pirfenidon.
English: Dose adjustments or temporary treatment discontinuation may be necessary in mild to severe cases of photosensitivity reaction or rash (see section 4.2).
Danish: Dosisjusteringer eller midlertidig afbrydelse af behandlingen kan være nødvendig ved milde til svære tilfælde af lysfølsomhedsreaktioner eller udslæt (se pkt.
English: However, since plasma levels of pirfenidone may be increased in some individuals with mild to moderate hepatic impairment, caution should be used with Esbriet treatment in this population.
Danish: Da plasmakoncentrationen af pirfenidon kan være forhøjet hos nogle personer med mildt til moderat nedsat leverfunktion, bør der udvises forsigtighed ved behandling med Esbriet i denne population.
English: The clinical efficacy of Esbriet has been studied in four Phase 3, multicentre, randomised, double-blind, placebo-controlled studies in patients with IPF.
Danish: Den kliniske virkning af Esbriet er undersøgt i fire randomiserede, dobbeltblindede placebokontrollerede fase 3-multicenterstudier med IPF-patienter.
English: Following oral administration of a single dose of 801 mg to healthy older adult volunteers (50-66 years of age) in the fed state, the rate of pirfenidone absorption slowed, while the AUC in the fed state was approximately 80-85% of the AUC observed in the fasted state.
Danish: Efter oral administration af en enkelt dosis på 801 mg til raske frivillige ældre (50-66 år) i ikke-fastende tilstand faldt pirfenidons absorptionshastighed, mens AUC i ikke-fastende tilstand var omkring 80-85 % af det AUC, der blev observeret i fastende tilstand.
English: ● If you experience yellowing of the eyes or skin, or dark urine, potentially accompanied by itching of the skin, which are signs of abnormal liver function tests.
Danish: · Hvis du oplever gulfarvning af øjne eller hud eller mørk urin, eventuelt ledsaget af hudkløe, hvilket er tegn på unormale leverfunktionstests.
English: In subjects with moderate hepatic impairment (i.e. Child-Pugh Class B), pirfenidone exposure was increased by 60%.
Danish: Hos patienter med moderat nedsat leverfunktion (dvs. Child-Pugh Class B) blev pirfenidoneksponeringen øget med 60 %.
English: Co-administration of Esbriet and 750 mg of ciprofloxacin (a moderate inhibitor of CYP1A2) increased the exposure to pirfenidone by 81%.
Danish: Samtidig administration af Esbriet og 750 mg ciprofloxacin (en moderat CYP1A2-hæmmer) øgede eksponeringen for pirfenidon med 81 %.
English: PVC/Aclar (PCTFE) aluminium foil blister Pack sizes
Danish: PVC/Aclar (PCTFE) aluminiumsfolie blisterpakninger Pakningsstørrelser
English: Results showed that there was a mean increase of 60% in pirfenidone exposure after a single dose of 801 mg pirfenidone (3 x 267 mg capsule) in patients with moderate hepatic impairment.
Danish: Resultaterne viste, at der var en gennemsnitlig stigning på 60 % i pirfenidoneksponeringen efter en enkelt dosis på 801 mg pirfenidon (3 x 267 mg kapsel) hos patienter med moderat nedsat leverfunktion.
English: Weight decreased; decreased appetite Psychiatric disorders Common
Danish: Vægttab, nedsat appetit Psykiske forstyrrelser Almindelig
English: Brown S-1-16530 or 03A2 inks containing:
Danish: Brun S-1-16530-eller 03A2-blæk indeholdende: Shellac
English: Always take this medicine exactly as your doctor or pharmacist has told you.
Danish: Tag altid lægemidlet nøjagtigt efter lægens eller apotekspersonalets anvisninger.
English: In vitro and in vivo extrapolations indicate that strong and selective inhibitors of CYP1A2 (e.g. enoxacin) have the potential to increase the exposure to pirfenidone by approximately 2 to 4-fold.
Danish: In vitro- og in vivo-ekstrapolationer tyder på, at potente og selektive CYP1A2-hæmmere (f.eks. enoxacin) har potentiale til at øge eksponeringen for pirfenidon ca. 2 til 4 gange.
English: NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Roche Registration GmbH
Danish: NAVN OG ADRESSE PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN Roche Registration GmbH
English: Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Danish: Fortæl altid lægen eller apotekspersonalet, hvis du bruger anden medicin, har gjort det for nylig eller vil tage anden medicin.
English: Upon initiating treatment, the dose should be titrated to the recommended daily dose of 2403 mg/day over a 14-day period as follows:
Danish: Efter initiering af behandling bør dosis optitreres til den anbefalede daglige dosis på 2403 mg/dag over en 14-dages periode på følgende måde:
English: The primary endpoint in both studies was the change from Baseline to Week 72 in percent predicted Forced Vital Capacity (FVC).
Danish: Det primære effektmål i begge studier var ændringen fra udgangspunktet til uge 72 i procent forventet forceret vitalkapacitet (FVC).
English: A reduced incidence of adverse events (nausea and dizziness) was observed in fed subjects when compared to the fasted group.
Danish: Der blev observeret lavere incidens af bivirkninger (kvalme og svimmelhed) hos ikke-fastende forsøgspersoner sammenlignet med den fastende gruppe.
English: If for any reason you have to stop taking Esbriet for more than 14 consecutive days, your doctor will restart your treatment with 1 capsule 3 times a day, gradually increasing this to 3 capsules 3 times a day.
Danish: Hvis du af en eller anden grund er nødt til at holde op med at tage Esbriet i mere end 14 dage efter hinanden, skal din læge starte behandlingen igen med én kapsel tre gange dagligt og gradvist øge dosen til tre kapsler tre gange dagligt.
English: Bioequivalence was demonstrated in the fasted state when comparing the 801 mg tablet to three 267 mg capsules.
Danish: Der blev demonstreret bioækvivalens i den fastende tilstand, når 801 mg tabletten sammenlignes med tre 267 mg kapsler.
English: Pirfenidone should be used with caution in patients with moderate renal impairment.
Danish: Pirfenidon skal anvendes med forsigtighed hos patienter med moderat nedsat nyrefunktion.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu.
Danish: DATO FOR ÆNDRING AF TEKSTEN Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmeside: http://www.ema.europa.eu.
English: ● History of angioedema with pirfenidone (see section 4.4).
Danish: · Anamnese med angioødem i forbindelse med pirfenidon (se pkt.
English: For treatment interruption of less than 14 consecutive days, the dose can be resumed at the previous recommended daily dose without titration.
Danish: Ved behandlingsafbrydelser på under 14 fortløbende dage kan dosis genoptages ved den tidligere anbefalede daglige dosis uden titrering.
English: Elevations in ALT and AST >3 × upper limit of normal (ULN) have been reported in patients receiving therapy with Esbriet.
Danish: Der er indberetninger om forhøjelser af ALAT og ASAT >3 × den øvre grænse for normalområdet (ULN) hos patienter, som er i behandling med Esbriet.
English: ● Concomitant use of fluvoxamine (see section 4.5).
Danish: · Samtidig brug af fluvoxamin (se pkt.
English: Elderly No dose adjustment is necessary in patients 65 years and older (see section 5.2).
Danish: Ældre Det er ikke nødvendigt at foretage dosisjustering hos patienter på 65 år eller derover (se pkt.
English: Two percent of patients had percent predicted FVC below 50% and 21% of patients had a percent predicted DLCO below 35% at Baseline.
Danish: To procent af patienterne havde procent forventet FVC under 50 %, og 21 % af patienterne havde procent forventet DLCO under 35 % ved udgangspunktet.
English: If you forget to take Esbriet
Danish: Hvis du har glemt at tage Esbriet
English: The pharmacokinetics of pirfenidone and the 5-carboxy-pirfenidone metabolite were compared in subjects with moderate hepatic impairment (Child-Pugh Class B) and in subjects with normal hepatic function.
Danish: Farmakokinetikken for pirfenidon og 5-carboxy-pirfenidon-metabolitten blev sammenlignet hos patienter med moderat nedsat leverfunktion (Child-Pugh Class B) og hos patienter med normal leverfunktion.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Esbriet in all subsets of the paediatric population in IPF (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med Esbriet i alle undergrupper af den pædiatriske population med IPF (se pkt.
English: In the fed state, the 801 mg tablet met bioequivalence criteria based on the AUC measurements compared to the capsules, while the 90% confidence intervals for Cmax (108.26% - 125.60%) slightly exceeded the upper bound of standard bioequivalence limit (90% CI: 80.00% - 125.00%).
Danish: I den ikke-fastende tilstand opfyldte 801 mg tabletten kriterier for bioækvivalens sammenlignet med kapslerne, baseret på AUC målinger, mens 90 % konfidensintervallerne for Cmax (108,26 % - 125,60 %) overskred den øvre grænse af standard bioækvivalens grænsen en smule (90 % konfidensinterval: 80,00 % - 125,00 %).
English: If you are breast-feeding or plan to breast-feed speak to your doctor or pharmacist before taking Esbriet.
Danish: Hvis du ammer eller har planer om at amme, skal du tale med lægen eller apotekspersonalet, før du begynder at tage Esbriet.
English: Dose adjustments and other considerations for safe use Gastrointestinal events: In patients who experience intolerance to therapy due to gastrointestinal undesirable effects, patients should be reminded to take the medicinal product with food.
Danish: Dosisjusteringer og andre overvejelser vedrørende sikker brug Bivirkninger i mave-tarm-kanalen: Patienter, som ikke tåler behandlingen på grund af uønskede hændelser i mave-tarm-kanalen, skal mindes om at indtage lægemidlet sammen med føde.
English: Do not use this medicine after the expiry date which is stated on the bottle label, blister and carton after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på beholderens etiket, blisterkortet og æsken efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: This may become clinically relevant in patients with moderate renal impairment where plasma exposure to 5-carboxy-pirfenidone is increased.
Danish: Dette kan blive klinisk relevant hos patienter med moderat nedsat nyrefunktion, hvor plasmaeksponering for 5-carboxy-pirfenidon er øget.
English: In the event of significant elevation of liver aminotransferases the dose of Esbriet should be adjusted or treatment discontinued according to the guidelines listed below.
Danish: I tilfælde af en signifikant forhøjelse af leveraminotransferaser bør dosis af Esbriet justeres, eller behandlingen afbrydes efter nedenstående retningslinjer.
English: In a total of 555 patients, the median baseline percent predicted FVC and %DLCO were 68% (range: 48-91%) and 42% (range: 27-170%), respectively.
Danish: Hos i alt 555 patienter var medianprocenten i forventet FVG og % DLCO ved udgangspunktet henholdsvis 68 % (48-91 %) og 42 % (27-170 %).
English: ● You should not take other medicines, such as tetracycline antibiotics (such as doxycycline),
Danish: · Du må ikke tage anden medicin som antibiotika af tetracyclintypen (f.eks. doxycyclin), som kan gøre dig mere følsom over for sollys.
English: Cigarette smoking and inducers of CYP1A2
Danish: Rygning og CYP1A2-induktorer
English: Patients who experience severe photosensitivity reaction or rash should be instructed to interrupt the dose and to seek medical advice (see section 4.4).
Danish: Patienter, som oplever en alvorlig lysfølsomhedsreaktion eller udslæt, skal instrueres om, at de skal afbryde dosis og søge læge (se pkt.
English: D CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Danish: BETINGELSER ELLER BEGRÆNSNINGER MED HENSYN TIL SIKKER OG EFFEKTIV ANVENDELSE AF LÆGEMIDLET
English: No dose adjustment is necessary in patients with mild to moderate hepatic impairment (i.e. Child-Pugh Class A and B).
Danish: Dosisjustering er ikke nødvendig hos patienter med mild til moderat nedsat leverfunktion (dvs. ChildPugh Class A eller B).
English: The study (SP3) in Japanese patients compared pirfenidone 1800 mg/day (comparable to 2403 mg/day in the US and European populations of PIPF-004/006 on a weight-normalised basis) with placebo (N=110, N=109, respectively).
Danish: Studiet med japanske patienter (SP3) sammenlignede pirfenidon 1800 mg/dag (sammenligneligt med 2403 mg/dag i amerikanske og europæiske populationer i PIPF-004/006 med vægtnormalisering) med placebo (henholdsvis N=110, N=109).
English: Pharmacotherapeutic group: Immunosuppressants, other immunosuppressants, ATC code: L04AX05 The mechanism of action of pirfenidone has not been fully established.
Danish: Farmakoterapeutisk klassifikation: Immunosuppressive stoffer, andre immunosuppressive stoffer, ATC-kode: L04AX05
English: No adverse effects on fertility were observed in preclinical studies (see section 5.3).
Danish: Der blev ikke observeret nogen bivirkning på fertiliteten i de prækliniske studier (se pkt.
English: If you forget a dose, take it as soon as you remember.
Danish: Hvis du har glemt en dosis, skal du tage den, så snart du husker det. Du må ikke tage en dobbeltdosis som erstatning for den glemte dosis.
English: There are 14 x 2-day blister strips each containing 18 capsules (3 capsules per pocket).
Danish: Der er 14 x 2 dages blisterstrip med hver 18 kapsler (3 kapsler pr. lomme).
English: Patients should be encouraged to discontinue use of strong inducers of CYP1A2 and to stop smoking before and during treatment with pirfenidone.
Danish: Patienterne bør opfordres til at ophøre med at bruge stærke CYP1A2induktorer og til rygestop før og under behandling med pirfenidon.
English: Esbriet should be used with caution in patients with moderate (CrCl 30-50 ml/min) renal impairment.
Danish: Esbriet skal anvendes med forsigtighed hos patienter med moderat (CrCl 30-50 ml/min) nedsat nyrefunktion.
English: Compared to the fasted state, administration of either formulation with food reduced pirfenidone Cmax, with Esbriet tablet reducing the Cmax slightly less (by 40%) than Esbriet capsules (by 50%).
Danish: Sammenlignet med fastende tilstand, reduceres pirfenidon Cmax ved administrering af de to formuleringer med føde, med Esbriet tablet reduceres Cmax en anelse mindre (med 40 %) end med Esbriet kapsler (med 50 %).
English: There are 14 x 18 capsules in PVC/PE/PCTFE aluminium foil perforated blister strips for a total of 252 capsules per pack.
Danish: Der er 14 x 18 kapsler i PVC/PE/PCTFE perforerede aluminiumsblisterstrip, i alt 252 kapsler pr. pakning.