FrancophonIA/ELRC3.0 huggingface dataset:
English: Fusidic acid used to treat long-term infections of the bones and joints may be taken under doctor's supervision (see Other medicines and Kaletra section);
Croatian: Sildenafil koji se koristi za liječenje erektilne disfunkcije može se koristiti samo pod liječničkim nadzorom (pogledajte dio Drugi lijekovi i Kaletra); • pripravke koji sadrže gospinu travu (Hypericum perforatum).
English: Oral contraceptives Ethinyl Oestradiol
Croatian: Oralni kontraceptivi Etinilestradiol
English: • steroids (e.g. budesonide, dexamethasone, fluticasone propionate, ethinyl oestradiol,
Croatian: • steroidi (npr. budezonid, deksametazon, flutikazonpropionat, etinilestradiol, triamcinolon).
English: Apalutamide
Croatian: Apalutamid
English: Nucleoside/Nucleotide reverse transcriptase inhibitors (NRTIs) Stavudine, Lamivudine Lopinavir: ↔
Croatian: Nukleozidni/nukleotidni inhibitori reverzne transkriptaze (NRTI; engl. nucleoside/nucleotide reverse transcriptase inhibitor)
English: Study M98-863 was a randomised, double-blind trial of 653 antiretroviral treatment naïve patients investigating Kaletra (400/100 mg twice daily) compared to nelfinavir (750 mg three times daily) plus stavudine and lamivudine.
Croatian: Studija M98-863 bilo je randomizirano, dvostruko slijepo ispitivanje lijeka Kaletra (400/100 mg dvaput na dan) u usporedbi s nelfinavirom (750 mg triput na dan) plus stavudin i lamivudin u 653 bolesnika bez prethodne antiretrovirusne terapije.
English: It is important that Kaletra tablets are swallowed whole and not chewed, broken or crushed.
Croatian: Važno je da Kaletra tablete progutate cijele, nemojte ih žvakati, lomiti ili drobiti.
English: • If the ‘ml' mark on the black ‘O' ring is less than the prescribed dose, draw up more solution to the prescribed dose.
Croatian: • Ako je broj „ml“ u ravnini s crnim „O“ prstenom manji od propisane doze, uvucite još otopine kako biste dobili propisanu dozu.
English: Caution should be exercised in administering ceritinib with Kaletra.
Croatian: Potreban je oprez kada se ceritinib primjenjuje zajedno s lijekom Kaletra.
English: Kaletra tablets are administered orally and must be swallowed whole and not chewed, broken or crushed.
Croatian: Kaletra tablete se primjenjuju peroralno i moraju se progutati cijele, ne smiju se žvakati, lomiti ili drobiti.
English: Each tablet of Kaletra contains 100 mg of lopinavir and 25 mg of ritonavir
Croatian: Svaka tableta lijeka Kaletra sadrži 100 mg lopinavira i 25 mg ritonavira
English: Uncommon Creatinine clearance decreased, nephritis, haematuria
Croatian: Manje često Smanjenje klirensa kreatinina, nefritis, hematurija
English: Kaletra is also supplied as 100 mg/25 mg film-coated tablets.
Croatian: Kaletra je također dostupna u obliku 100 mg/25 mg filmom obloženih tableta.
English: Due to CYP3A and P-gp inhibition by lopinavir/ritonavir.
Croatian: Zbog inhibicije CYP3A i Pgp-a lopinavirom/ritonavirom.
English: Concomitant administration of Kaletra with colchicine in patients with renal and/or hepatic impairment is contraindicated due to a potential increase of colchicine-related serious and/or life-threatening reactions such as neuromuscular toxicity (including rhabdomyolysis) (see sections 4.3 and 4.4).
Croatian: Istodobna primjena lijeka Kaletra i kolhicina je kontraindicirana kod bolesnika s oštećenjem funkcije bubrega i/ili jetre jer može doći do povećanja ozbiljnih i/ili po život opasnih reakcija povezanih s kolhicinom poput neuromuskularne toksičnosti (uključujući rabdomiolizu) (vidjeti dijelove 4.3 i 4.4).
English: Body weight (kg) Twice daily oral solution dose (dose in mg/kg)
Croatian: Doziranje oralne otopine dvaput na dan (doza u mg)
English: Large decreases in lopinavir concentrations may be observed due to CYP3A induction by rifampicin.
Croatian: Moguće su jako smanjene koncentracije lopinavira zbog indukcijskog učinka rifampicina na CYP3A.
English: The concomitant administration of Kaletra and ranolazine is contraindicated (see section 4.3).
Croatian: Istodobna primjena lijeka Kaletra i ranolazina je kontraindicirana (vidjeti dio 4.3).
English: Concomitant administration of Kaletra and cisapride is contraindicated as it may increase the risk of serious arrhythmias from this agent (see section 4.3).
Croatian: Istodobna primjena lijeka Kaletra i cisaprida je kontraindicirana jer može povećati rizik od ozbiljnih aritmija uzrokovanih tim lijekom (vidjeti dio 4.3).
English: It belongs to a group of medicines called protease inhibitors.
Croatian: Kaletra je antiretrovirusni lijek i spada u skupinu lijekova koje nazivamo inhibitorima proteaze.
English: Median baseline CD4 cell count was 220 cells/mm3 (range13 to 1030 cells/mm3).
Croatian: Na početku je ispitivanja medijan broja CD4 stanica iznosio 220 stanica/mm³ (raspon 13 do 1030 stanica/mm³).
English: Concentrations may be increased due to CYP3A4 inhibition by lopinavir/ritonavir.
Croatian: Koncentracije mogu biti povećane zbog inhibicije CYP3A4 lopinavirom/ritonavirom.
English: Concentrations may be affected when co-administered with lopinavir/ritonavir due to CYP2C9 induction.
Croatian: Pri istodobnoj primjeni s lopinavirom/ritonavirom moguć je utjecaj na koncentracije varfarina zbog indukcije CYP2C9.
English: Kaletra contains lopinavir and ritonavir, both of which are inhibitors of the P450 isoform CYP3A in vitro.
Croatian: Kaletra sadrži lopinavir i ritonavir, koji su oba inhibitori P450 izoforme CYP3A in vitro.
English: • Nausea, vomiting, abdominal pain as large increases in the amount of triglycerides (fats in the blood) have been considered a risk factor for pancreatitis (inflammation of the pancreas) and these symptoms may suggest this condition.
Croatian: • Mučninu, povraćanje, bol u trbuhu jer to može upućivati na pankreatitis (upalu gušterače) za koji povećana koncentracija triglicerida (masnoće u krvi) predstavlja rizičan faktor.
English: Kaletra 200 mg/50 mg film-coated tablets lopinavir/ritonavir
Croatian: Kaletra 200 mg/50 mg filmom obložene tablete lopinavir/ritonavir
English: LIST OF EXCIPIENTS
Croatian: Opis izabranih nuspojava
English: Increased risk of side-effects (respiratory depression, sedation) due to higher plasma concentrations because of CYP3A4 inhibition by lopinavir/ritonavir.
Croatian: (depresija disanja, sedacija) uslijed viših koncentracija u plazmi, nastalih zbog inhibicije CYP3A4 lopinavirom/ritonavirom.
English: Life-threatening and fatal drug interactions have been reported in patients treated with colchicine and strong inhibitors of CYP3A like ritonavir.
Croatian: U bolesnika liječenih kolhicinom i snažnim inhibitorima CYP3A poput ritonavira zabilježene su po život opasne i fatalne interakcije lijekova.
English: Thereby, increasing the risk of serious haematologic abnormalities, or other serious adverse effects from this agent (see section 4.5).
Croatian: Time je povišen rizik od ozbiljnih hematoloških poremećaja i ostalih ozbiljnih nuspojava uzrokovanih ovom tvari (vidjeti dio 4.5).
English: Contents of the pack and other information
Croatian: Kako čuvati lijek Kaletra Sadržaj pakiranja i druge informacije
English: One-hundred thirteen nelfinavir-treated patients and 74 lopinavir/ritonavir-treated patients had an HIV RNA above 400 copies/ml while on treatment from Week 24 through Week 96.
Croatian: RNK iznad 400 kopija/ml tijekom liječenja od 24 do 96 tjedna.
English: Copovidone, sorbitan laurate, colloidal anhydrous silica, sodium stearyl fumarate.
Croatian: Kopovidon, sorbitanlaurat, bezvodni, koloidni silicijev dioksid, natrijev stearilfumarat.
English: HIV RNA < 400 copies/ml* Median change from baseline in CD4+ T-cell count (cells/mm3)
Croatian: HIV RNK < 400 kopija/ml* Medijan promjene od početnog broja CD4+ T-stanica (stanica/mm3)
English: • antifungals (e.g. ketoconazole, itraconazole, voriconazole);
Croatian: • lijekovi za liječenje gljivičnih infekcija (npr. ketokonazol, itrakonazol, vorikonazol);
English: • If the ‘ml' mark on the black ‘O' ring is more than the prescribed dose, push the plunger to the prescribed dose.
Croatian: • Ako je broj „ml“ u ravnini s crnim „O“ prstenom veći od propisane doze, potiskujte klip dok se prsten ne poravna s oznakom za propisanu dozu.
English: Adult patients who have previously taken other antiviral medicines can take Kaletra tablets once daily as an 800 mg/200 mg dose if their doctor decides it is appropriate.
Croatian: Odrasli bolesnici koji su prethodno uzimali druge antivirusne lijekove mogu uzimati Kaletra tablete jednom dnevno u dozi od 800 mg/200
English: (increase is indicated as “↑”, decrease as “↓”, no change as “↔”,once daily as “QD”, twice daily as
Croatian: U tablici su navedene interakcije između lijeka Kaletra i istodobno primijenjenih lijekova (povišenje je označeno strelicom „↑“, sniženje strelicom „↓“, bez promjene strelicom „↔“, doziranje jedanput na dan oznakom „QD“, dvaput na dan oznakom „BID“, a triput na dan oznakom „TID“).
English: The pharmacokinetics of Kaletra 300/75 mg/m2 twice daily with nevirapine and 230/57.5 mg/ m2 twice daily alone have been studied in 53 paediatric patients ranging in age from 6 months to 12 years.
Croatian: Farmakokinetika lijeka Kaletra u dozi od 300/75 mg/m² dvaput na dan u kombinaciji s nevirapinom te u dozi od 230/57,5 mg/m² dvaput na dan bez drugih lijekova ispitivala se u ukupno 53 pedijatrijska bolesnika u dobi od 6 mjeseci do 12 godina.
English: Package leaflet: Information for the user Kaletra 100 mg/25 mg film-coated tablets lopinavir/ritonavir
Croatian: Uputa o lijeku: Informacije za korisnika Kaletra 100 mg/25 mg filmom obložene tablete lopinavir/ritonavir
English: Kaletra contains potassium as acesulfame potassium, which may be harmful to people on a low potassium diet. High potassium in the blood can cause stomach upset and diarrhoea.
Croatian: Kaletra sadrži kalij u obliku acesulfamkalija, koji može biti štetan bolesnike s ograničenjem unosa kalija.
English: Package leaflet: Information for the user Kaletra 200 mg/50 mg film-coated tablets lopinavir/ritonavir
Croatian: Uputa o lijeku: Informacije za korisnika Kaletra 200 mg/50 mg filmom obložene tablete lopinavir/ritonavir
English: Safety, efficacy and pharmacokinetic profiles of the two dose regimens were assessed after 3 weeks of therapy in each patient.
Croatian: tjedna liječenja procijenjeni sigurnost, djelotvornost i farmakokinetički profil dvaju režima primjene.
English: − If you notice you miss a dose within 12 hours of your normal dosing time, take your missed dose as soon as possible, and then continue with your normal dose at the regular time as prescribed by your doctor.
Croatian: Ako uzimate lijek Kaletra jedanput na dan ̵ Ako unutar 12 sati od vremena kada ste trebali uzeti lijek primijetite da ste propustili uzeti jednu dozu, što prije uzmite propuštenu dozu, a potom nastavite uzimati lijek prema uobičajenom rasporedu kako Vam je propisao Vaš liječnik.
English: Glecaprevir/pibrentasvir Serum concentrations may be increased due to P-glycoprotein, BCRP and OATP1B inhibition by lopinavir/ritonavir.
Croatian: Glekaprevir/pibrentasvir Serumske koncentracije mogu biti povećane zbog inhibicijskog učinka lopinavira/ritonavira na P-glikoprotein, BCRP i OATP1B (polipeptid za prijenos organskih aniona (engl. organic anion transporting polypeptide)).
English: This may cause nausea, vomiting, colic, severe purgation at high doses.
Croatian: Uzeto u visokim dozama može izazvati mučninu, povraćanje, kolike (grčevi u trbuhu) i jak proljev.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING 100 mg/ 25 mg tablets - Carton of 1 bottle
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU 100 mg/ 25 mg tablete - Kutija s 1 bocom
English: Dihydroergotamine, ergonovine, ergotamine, methylergonovine
Croatian: Dihidroergotamin, ergonovin, ergotamin, metilergonovin
English: Open the child-proof cap by pushing down on it with your palm and twisting it counter clockwise, or in the direction of the arrow on the top of the cap. Talk to your pharmacist if you have difficulty opening the bottle.
Croatian: Otvorite zatvarač siguran za djecu tako da ga pritisnete dlanom i zavrnete obrnuto od kazaljke na satu ili u smjeru strelice na vrhu zatvarača.
English: Mean baseline CD4+ T-cell count was 259 cells/mm3 (range: 2 to 949 cells/ mm3) and mean baseline plasma HIV-1 RNA was 4.9 log10 copies/ml (range: 2.6 to 6.8 log10 copies/ml).
Croatian: Srednja početna vrijednost broja CD4+ T stanica je bila 259 stanica/mm3 (raspon 2 do 949 stanica/mm3) i srednja početna vrijednost HIV-1 RNK u plazmi je bila 4,9 log10 kopija/ml (raspon: 2,6 do 6,8 log10 kopija/ml).
English: Antiarrhythmics
Croatian: Antiaritmici
English: Increased plasma concentrations of fusidic acid.
Croatian: Povišena koncentracija fusidatne kiseline u plazmi.
English: AUC: ↔ Cmax: ↔ C12: ↓ 30% Lopinavir: ↔
Croatian: AUC: ↔ Cmax: ↔ C12: ↓ 30%
English: The concomitant administration with quetiapine is contraindicated (see section 4.5).
Croatian: Istodobna primjena s kvetiapinom je kontraindicirana (vidjeti dio 4.5).
English: Furthermore, polyoxol 40 hydrogenated castor oil and potassium present in Kaletra oral solution may cause only at high inadvertent doses gastrointestinal upset.
Croatian: također prisutni u Kaletra oralnoj otopini, mogu samo pri velikim, nehotice uzetim dozama izazvati gastrointestinalne smetnje.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING 200 mg/50 mg tablets - Carton of 1 bottle
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU 200 mg/50 mg tablete - kutija s 1 bocom
English: Ergot alkaloids Dihydroergotamine, ergonovine, ergotamine, methylergonovine
Croatian: Ergot alkaloidi Dihidroergotamin, ergonovin, ergotamin, metilergonovin
English: GI motility agent Cisapride
Croatian: Lijekovi koji utječu na gastrointestinalni motilitet Cisaprid
English: Mean baseline CD4+ T-cell count was 216 cells/mm3 (range: 20 to 775 cells/mm3) and mean baseline plasma HIV-1 RNA was 5.0 log10 copies/ml (range: 1.7 to 7.0 log10 copies/ml).
Croatian: Srednja početna vrijednost broja stanica CD4+ bila je 216 stanica/mm³ (raspon od 20 do 775 stanica/mm³), a srednja početna vrijednost HIV-1 RNK u plazmi bila je 5,0 log10 kopija/ml (raspon od 1,7 do 7,0 log10 kopija/ml).
English: Increased plasma concentrations of ranolazine which may increase the potential for serious and/or lifethreatening reactions (see section 4.5).
Croatian: Povišena koncentracija ranolazina u plazmi, što može povećati mogućnost nastupa ozbiljnih i/ili po život opasnih reakcija (vidjeti dio 4.5).
English: Medicinal products within class
Croatian: Skupina lijekova Lijek unutar skupine
English: • If the ‘ml' mark on the collar is more than the prescribed dose, push the plunger to the prescribed dose.
Croatian: • Ako je broj „ml“ u ravnini obruča veći od propisane doze, potiskujte klip dok se obruč ne poravna s oznakom za propisanu dozu.
English: Kaletra 200 mg/50 mg film-coated tablets:
Croatian: Kaletra 200 mg/50 mg filmom obložene tablete:
English: Increased plasma concentrations of lurasidone which may increase the potential for serious and/or lifethreatening reactions (see section 4.5).
Croatian: Povišena koncentracija lurasidona u plazmi, što može povećati mogućnost nastupa ozbiljnih i/ili po život opasnih reakcija (vidjeti dio 4.5).
English: Mean increase from baseline in CD4+ T-cell count (cells/mm3)
Croatian: Srednja vrijednost porasta od početne vrijednosti u broju CD4+ T-stanica (stanica/mm3)
English: • Kaletra is not a cure for HIV infection or AIDS.
Croatian: • Kaletra neće izliječiti HIV infekciju ni sindrom stečene imunodeficijencije (AIDS; engl.
English: The following table contains dosing guidelines for Kaletra 100/25 mg tablets based on BSA when used in combination with efavirenz or nevirapine in children.
Croatian: Sljedeća tablica sadrži smjernice za doziranje Kaletra tableta, korištenih u djece u kombinaciji s efavirenzom ili nevirapinom, temeljeno na površini tijela.
English: Cases of pancreatitis have been reported in patients receiving Kaletra, including those who developed hypertriglyceridaemia.
Croatian: U bolesnika liječenih lijekom Kaletra, uključujući i one koji su oboljeli od hipertrigliceridemije, zabilježena je pojava pankreatitisa.
English: Refer to the afatinib SmPC for
Croatian: Vidjeti sažetak opisa svojstava lijeka za afatinib za
English: HIV RNA < 400 copies/ml Mean increase from baseline in CD4+ T-cell count (cells/mm3)
Croatian: HIV RNK < 400 kopija/ml Srednja vrijednost porasta od početne vrijednosti u broju CD4+ T-stanica (stanica/mm3)
English: Cmax: ↑ 5-fold
Croatian: Cmax: ↑ 5 puta
English: Cmax: ↑ 6-fold
Croatian: Cmax: ↑ 6 puta
English: • non-nucleoside reverse transcriptase inhibitors (NNRTIs) (e.g. efavirenz, nevirapine);
Croatian: Nenukleozidni inhibitori reverzne transkriptaze (NNRTI; engl. non-nucleoside reverse transcriptase inhibitor)
English: All patients were non-nucleoside reverse transcriptase inhibitor naïve.
Croatian: Nijedan bolesnik nije prethodno primao nenukleozidne inhibitore reverzne transkriptaze.
English: The adult dose of Kaletra tablets (400/100 mg twice daily) may be used in children 40 kg or greater or with a Body Surface Area (BSA)* greater than 1.4 m2. For children weighing less than 40 kg or with a BSA between 0.5 and 1.4 m2 and able to swallow tablets, refer to the dosing guideline tables below.
Croatian: Doza Kaletra tableta za odrasle (400/100 mg dvaput na dan) može se koristiti kod djece s 40 kg ili više ili s površinom tijela (PT)* većom od 1,4 m2.
English: Median baseline CD4 cell count was 349 cells/mm3 (range 72 to 807 cells/mm3) and median baseline plasma HIV-1 RNA was 4.0 log10 copies/ml (range 2.9 to 5.8 log10 copies/ml).
Croatian: Na početku je ispitivanja medijan broja CD4 stanica u plazmi iznosio 349 stanica/mm³ (raspon 72 do 807 stanica/mm³), a medijan HIV-1 RNK u plazmi 4,0 log10 kopija/ml (raspon od 2,9 do 5,8 log10 kopija/ml).
English: Patients with prior antiretroviral therapy
Croatian: Bolesnici koji su već ranije primali antiretrovirusnu terapiju
English: Read the package leaflet before use.
Croatian: Pažljivo pročitajte cijelu uputu prije nego
English: Patients were randomised to either 230 mg lopinavir/57.5 mg ritonavir per m2 or 300 mg lopinavir/75 mg ritonavir per m2. Naïve patients also received nucleoside reverse transcriptase inhibitors.
Croatian: Bolesnici su randomizirani u dvije skupine, od kojih je jedna primala 230 mg lopinavira/57,5 mg ritonavira po m², a druga 300 mg lopinavira/75 mg ritonavira po m².
English: Consequently, concomitant administration of Kaletra and these glucocorticoids is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4).
Croatian: osim ako očekivana korist od liječenja ne nadmašuje rizik od sistemskih učinaka kortikosteroida (vidjeti dio 4.4).
English: At entry, median (range) HIV-1 RNA was 6.0 (4.7-7.2) log10 copies/ml and median (range) CD4+T-cell percentage was
Croatian: Medijan (raspon) vrijednosti HIV-1 RNK pri uključivanju u ispitivanje iznosio je 6,0 (4,7-7,2) log10 kopija/ml, dok je medijan (raspon) postotka CD4+ T-stanica iznosio 41 (16-59).
English: A more pronounced effect on bedaquiline plasma exposures may be observed during prolonged co-administration with lopinavir/ritonavir.
Croatian: Cmax: ↔ Mogući je izraženiji učinak na izloženost bedakilinu u plazmi tijekom produljene istodobne primjene s lopinavirom/ritonavirom.
English: Kaletra is also supplied as 200 mg/50 mg film-coated tablets.
Croatian: Kaletra je također dostupna u obliku 200 mg/50 mg filmom obloženih tableta.
English: Film-coated tablet Yellow debossed with [Abbott logo] and “KA”.
Croatian: Filmom obložena tableta Žuta, s utisnutim [logotipom Abbotta] i oznakom “KA”.
English: The use of avanafil with Kaletra is contraindicated (see section 4.3).
Croatian: Primjena avanafila s lijekom Kaletra je kontraindicirana (vidjeti dio 4.3).
English: Kaletra 100 mg/25 mg film-coated tablets
Croatian: Kaletra 100 mg/25 mg filmom obložene tablete
English: Markedly increased plasma concentrations due to CYP3A inhibition by lopinavir/ritonavir.
Croatian: Značajno povećane koncentracije u plazmi zbog inhibicijskog učinka lopinavira/ritonavira na CYP3A.
English: Kaletra must not be administered once daily in combination with amprenavir.
Croatian: U kombinaciji s amprenavirom Kaletra se ne smije davati jednom dnevno.
English: Please refer to the Kaletra 100 mg/25 mg film-coated tablets Summary of Product Characteristics.
Croatian: Molimo pogledajte sažetak opisa svojstava lijeka za Kaletra 100 mg/25 mg filmom obložene tablete.
English: Due to CYP3A4 inhibition by lopinavir/ritonavir.
Croatian: Zbog inhibicije CYP3A4 lopinavirom/ritonavirom.
English: It is important to note that cases of pancreatitis have been reported in patients receiving Kaletra, including those who developed hypertriglyceridaemia.
Croatian: Važno je napomenuti da je u bolesnika koji su uzimali lijek Kaletra bilo i prijava pankreatitisa,
English: Each film-coated tablet contains 100 mg of lopinavir co-formulated with 25 mg of ritonavir as a pharmacokinetic enhancer.
Croatian: Svaka filmom obložena tableta sadrži 100 mg lopinavira u kombinaciji s 25 mg ritonavira kao farmakokinetičkog pojačivača.
English: Kaletra film-coated tablets are pale yellow debossed with [Abbott logo] and “KC”.
Croatian: Kaletra filmom obložene tablete su svijetlo žute boje s utisnutim [logotipom Abbotta] i oznakom “KC”.
English: Due to CYP3A inhibition by lopinavir/ritonavir, concentrations of alfuzosin are expected to increase.
Croatian: Zbog inhibicije CYP3A lopinavirom/ritonavirom, očekuje se povećanje koncentracije alfuzosina.
English: Each film-coated tablet contains 200 mg of lopinavir co-formulated with 50 mg of ritonavir as a pharmacokinetic enhancer.
Croatian: Svaka filmom obložena tableta sadrži 200 mg lopinavira u kombinaciji s 50 mg ritonavira kao farmakokinetičkog pojačivača.
English: Thereby, increasing the risk of serious arrhythmias from this agent (see section 4.5).
Croatian: Time je povišen rizik od ozbiljnih aritmija uzrokovanih ovom tvari (vidjeti dio 4.5).
English: Co-administration of abemaciclib and Kaletra should be avoided.
Croatian: Potrebno je izbjegavati istodobnu primjenu abemacikliba i lijeka Kaletra.
English: • anticancer medicines (e.g. abemaciclib, afatinib, apalutamide, ceritinib, encorafenib, ibrutinib, venetoclax, most tyrosine kinases inhibitors such as dasatinib and nilotinib, also vincristine and vinblastine);
Croatian: ibrutinib, venetoklaks, većina inhibitora tirozin kinaze kao što su dasatinib i nilotinib, ali i vinkristin i vinblastin);
English: Increased plasma concentrations of colchicine.
Croatian: Povišena koncentracija kolhicina u plazmi.
English: Kaletra tablets must be swallowed whole and not chewed, broken or crushed.
Croatian: Kaletra tablete moraju se progutati cijele, ne smiju se žvakati, lomiti ili drobiti.
English: Refer to the Summary of Product Characteristics for Kaletra oral solution for dosing instructions.
Croatian: Provjerite sažetak opisa svojstava lijeka Kaletra oralne otopine za upute o doziranju oralne otopine.
English: Mean baseline CD4+ T-cell count was 254 cells/mm3 (range: 4 to 952 cells/mm3) and mean baseline plasma HIV-1 RNA was 4.3 log10 copies/ml (range: 1.7 to 6.6 log10 copies/ml).
Croatian: Srednja početna vrijednost CD4+ T-stanica je bila 254 stanica/mm³ (raspon: 4 do 952 stanica/mm³) i srednja početna vrijednost HIV-1 RNK u plazmi bila je 4,3 log10 kopija/ml (raspon: 1,7 do 6,6 log10 kopija/ml).
English: Kaletra (80 mg + 20 mg) / ml oral solution
Croatian: Kaletra (80 mg + 20 mg) / ml oralna otopina
English: Hepatic Insufficiency
Croatian: Insuficijencija jetre
English: Antidepressants and Anxiolytics Trazodone single dose
Croatian: Antidepresivi i anksiolitici Trazodon u jednokratnoj dozi (Ritonavir, 200 mg BID)
English: Clinical monitoring of antiviral efficacy is recommended when these medicines are concomitantly administered with Kaletra.
Croatian: Kada se ti lijekovi daju istodobno s lijekom Kaletra preporučuje se kliničko praćenje protuvirusne djelotvornosti.
English: Furthermore, rare increases in PR interval have been reported during Kaletra therapy (see section 4.4).
Croatian: PR-intervala pri uzimanju lijeka Kaletra (vidjeti dio 4.4).