FrancophonIA/ELRC3.0 huggingface dataset:
English: Four mood stabilizer subgroups were assessed in the randomised phase: aripiprazole + lithium; aripiprazole + valproate; placebo + lithium; placebo + valproate.
Croatian: Četiri podskupine stabilizatora raspoloženja su se procjenjivale u randomiziranoj fazi: aripiprazol + litij, aripiprazol + valproat, placebo + litij, placebo + valproat.
English: It is used to treat adults and adolescents aged 15 years and older who suffer from a disease characterised by symptoms such as hearing, seeing or sensing things which are not there, suspiciousness, mistaken beliefs, incoherent speech and behaviour and emotional flatness.
Croatian: Koristi se za liječenje odraslih i adolescenata u dobi od 15 ili više godina koji boluju od bolesti karakterizirane simptomima kao što su to da bolesnik čuje, vidi ili osjeća stvari kojih nema, sumnjičavost, pogrešno vjerovanje, nepovezan govor i ponašanje te emocionalna tupost.
English: • Certain antibiotics used to treat tuberculosis (rifabutin, rifampicin)
Croatian: • određene antibiotike koji se primjenjuju za liječenje tuberkuloze (rifabutin, rifampicin).
English: However, the estimation of the HR for the younger (13 - 14 years) group was not precise, reflecting the smaller number of subjects in that group (aripiprazole, n = 29; placebo, n = 12), and the confidence interval for this estimation (ranging from 0.151 to 1.628) did not allow conclusions to be drawn on the presence of a treatment effect.
Croatian: Međutim, procjena HR-a u mlađoj (u dobi od 13 do 14 godina) skupini nije bila precizna zbog manjeg broja ispitanika u toj skupini (aripiprazol, n = 29; placebo, n = 12), a interval pouzdanosti ove procjene (u rasponu od 0,151 do 1,628) nije dopustio donošenje zaključka o prisutnosti terapijskog učinka.
English: Less than 1% of unchanged aripiprazole was excreted in the urine and approximately 18% was recovered unchanged in the faeces.
Croatian: Manje od 1 % neizmijenjenog aripiprazola izluči se mokraćom, a oko 18 % se otkrije u neizmijenjenom obliku u stolici.
English: • inability to resist the impulse, drive or temptation to perform an action that could be harmful to you or others, which may include:
Croatian: • nemogućnost odupiranja nagonu, porivu ili iskušenju za vršenje radnji koje bi mogle naškoditi
English: Taking Aripiprazole Zentiva with some medicines may mean the doctor will need to change your dose of Aripiprazole Zentiva or the other medicines.
Croatian: Uzimanje lijeka Aripiprazole Zentiva s nekim lijekovima može značiti da će Vam liječnik morati promijeniti dozu lijeka Aripiprazole
English: Aripiprazole Zentiva contains the active substance aripiprazole and belong to a group of medicines called antipsychotics.
Croatian: Zentiva sadrži djelatnu tvar aripiprazol i pripada skupini lijekova koji se zovu antipsihotici.
English: If you are an elderly patient suffering from dementia (loss of memory and other mental abilities), you or your carer/relative should tell your doctor if you have ever had a stroke or “mini” stroke.
Croatian: Ako ste starija osoba i bolujete od demencije (gubitka pamćenja i drugih mentalnih sposobnosti), Vi ili Vaš skrbnik/član obitelji morate obavijestiti liječnika ako ste preboljeli moždani udar ili „mali“ moždani udar.
English: Aripiprazole Zentiva is indicated for the treatment of schizophrenia in adults and in adolescents aged 15 years and older.
Croatian: Zentiva je indiciran za liječenje shizofrenije u odraslih i adolescenata u dobi od 15 i više godina.
English: Aripiprazole Zentiva is not recommended for use in patients with schizophrenia below 15 years of age due to insufficient data on safety and efficacy (see sections 4.8 and 5.1).
Croatian: Zentiva se ne preporučuje za primjenu u bolesnika sa shizofrenijom mlađih od 15 godina, zbog nedostatnih podataka o sigurnosti i djelotvornosti (vidjeti dijelove 4.8 i 5.1).
English: In adults it also prevents this condition from returning in patients who have responded to the treatment with Aripiprazole Zentiva.
Croatian: Također sprječava povratak takvog stanja u odraslih bolesnika koji su prethodno imali odgovor na liječenje lijekom Aripiprazole Zentiva.
English: The overall completion rate was significantly higher for patients on aripiprazole (43%) than for haloperidol (30%).
Croatian: Ukupna stopa dovršetka ispitivanja bila je značajno viša u skupini bolesnika koji su uzimali aripiprazol (43 %) nego u onih na haloperidolu (30 %).
English: Hyperglycaemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotics, including aripiprazole.
Croatian: Hiperglikemija, koja je u nekim slučajevima bila izrazita i povezana s ketoacidozom, hiperosmolarnom komom ili smrću, bila je prijavljena u bolesnika liječenih atipičnim antipsihoticima, uključujući aripiprazol.
English: In clinical trials with aripiprazole, there were no significant differences in the incidence rates of hyperglycaemia-related adverse reactions (including diabetes) or in abnormal glycaemia laboratory values compared to placebo.
Croatian: U kliničkim ispitivanjima aripiprazola nije bilo značajnih razlika u stopama incidencije nuspojava povezanih s hiperglikemijom (uključujući šećernu bolest) ni u abnormalnim laboratorijskim vrijednostima glikemije u odnosu na placebo.
English: If you notice you are gaining weight, develop unusual movements, experience somnolence that interferes with normal daily activities, any difficulty in swallowing or allergic symptoms, please tell your doctor.
Croatian: Ako primijetite povećanje tjelesne težine, pojavu neuobičajenih pokreta, izrazitu pospanost koja Vas ometa u obavljanju normalnih svakodnevnih aktivnosti, poteškoće s gutanjem ili alergijske simptome, obavijestite o tome svog liječnika.
English: Sudden unexplained death Torsades de pointes QT prolongation Ventricular arrhythmias Cardiac arrest Bradycardia
Croatian: Srčani poremećaji tahikardija iznenadna neobjašnjiva smrt torsades de pointes produljenje QT intervala ventrikularne aritmije srčani arest bradikardija
English: Other medicines and Aripiprazole Zentiva
Croatian: Drugi lijekovi i Aripiprazole Zentiva
English: Pack size: 14, 28, 49, 56, or 98 tablets
Croatian: Veličina pakiranja: 14, 28, 49, 56 ili 98 tableta
English: • Rapid heartbeat, agitation/aggressiveness, problems with speech.
Croatian: • ubrzane otkucaje srca, uznemirenost/agresivnost, otežan govor,
English: In repeat-dose studies in juvenile rats and dogs, the toxicity profile of aripiprazole was comparable to that observed in adult animals, and there was no evidence of neurotoxicity or adverse reactions on development.
Croatian: U ispitivanjima ponovljenih doza u mladih štakora i pasa, profil toksičnosti aripiprazola bio je usporediv s onim u odraslih životinja i nije bilo dokaza neurotoksičnosti ni nuspojava vezanih uz razvoj.
English: Actual scores in rating scales used as secondary endpoints, including PANSS and the Montgomery-Asberg Depression Rating Scale showed a significant improvement over haloperidol.
Croatian: Stvarni rezultati na ocjenskim ljestvicama, uključujući PANSS i Montgomery-Asbergovu ocjensku skalu depresije, koji su se koristili kao sekundarne mjere ishoda, pokazali su značajno poboljšanje u odnosu na haloperidol.
English: In contrast the 95% confidence interval for the HR in the older subgroup (aripiprazole, n = 69; placebo, n = 36) was 0.242 to 0.879 and hence a treatment effect could be concluded in the older patients.
Croatian: Nasuprot tome, 95 %-tni interval pouzdanosti za HR u starijoj podskupini (aripiprazol, n = 69; placebo, n = 36) iznosio je 0,242 do 0,879 pa se stoga moglo zaključiti da je u starijih bolesnika bio prisutan terapijski učinak.
English: The active substance is aripiprazole.
Croatian: Djelatna tvar je aripiprazol.
English: At therapeutic concentrations, aripiprazole and dehydro-aripiprazole are greater than 99% bound to serum proteins, binding primarily to albumin.
Croatian: Pri terapijskim koncentracijama, više od 99 % aripiprazola i dehidro-aripiprazola vezano je za serumske proteine, prvenstveno za albumin.
English: Name and address of the manufacturer responsible for batch release Zentiva SA
Croatian: Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet Zentiva SA
English: • Certain medicines to treat HIV infection (such as efavirenz, nevirapine, an protease inhibitors e.g. indinavir, ritonavir)
Croatian: • određene lijekove za liječenje HIV-infekcije (kao što su efavirenz, nevirapin, inhibitori proteaze, npr. indinavir, ritonavir)
English: Elderly patients with dementia-related psychosis
Croatian: Stariji bolesnici sa psihozom povezanom s demencijom Povećan mortalitet
English: Potential for aripiprazole to affect other medicinal products In clinical studies, 10 - 30 mg/day doses of aripiprazole had no significant effect on the metabolism of substrates of CYP2D6 (dextromethorphan/3-methoxymorphinan ratio), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP3A4 (dextromethorphan).
Croatian: Potencijal aripiprazola da utječe na druge lijekove U kliničkim ispitivanjima, doze aripiprazola od 10 do 30 mg/dan nisu imale značajnog učinka na metabolizam supstrata CYP2D6 (omjer dekstrometorfan/3-metoksimorfinan), CYP2C9 (varfarin), CYP2C19 (omeprazol) ni CYP3A4 (dekstrometorfan).
English: • Triptans (such as sumatriptan and zolmitripitan) used for treating migraine
Croatian: • triptani (kao što su sumatriptan i zolmitriptan) koji se primjenjuju za liječenje migrene.
English: The most commonly reported adverse reactions in placebo-controlled trials were akathisia and nausea each occurring in more than 3% of patients treated with oral aripiprazole.
Croatian: Najčešće prijavljene nuspojave u placebom kontroliranim ispitivanjima bile su akatizija i mučnina, od kojih se svaka javlja u više od 3 % bolesnika liječenih oralnim aripiprazolom.
English: The most common treatment-emergent adverse events among patients receiving 30 mg were extrapyramidal disorder (28.3%), somnolence (27.3%), headache (23.2%), and nausea (14.1%).
Croatian: Nuspojave koje su se najčešće javljale tijekom liječenja u bolesnika koji su primali dozu od 30 mg bili su ekstrapiramidni poremećaj (28,3 %), somnolencija (27,3 %), glavobolja (23,2 %) i mučnina (14,1 %).
English: Tell your doctor immediately if you suffer from muscle stiffness or inflexibility with high fever, sweating, altered mental status, or very rapid or irregular heart beat.
Croatian: Odmah obavijestite svog liječnika ako bolujete od ukočenosti ili nesavitljivosti mišića s visokom vrućicom, znojenjem, promijenjenim mentalnim statusom ili jako ubrzanim ili nepravilnim otkucajima srca.
English: Do not use this medicine after the expiry date which is stated on the blister and the carton after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na blisteru i kutiji iza „Rok valjanosti“.
English: In a haloperidol-controlled trial, the proportion of responder patients maintaining response to medicinal product at 52-weeks was similar in both groups (aripiprazole 77% and haloperidol 73%).
Croatian: U haloperidolom kontroliranom ispitivanju, udio bolesnika u kojih se održao terapijski odgovor na lijek do 52. tjedna ispitivanja bio je sličan u obje skupine (aripiprazol 77 % i haloperidol 73 %).
English: Extrapyramidal symptoms were mainly reported during the stabilisation phase in 17% of patients, with tremor accounting for 6.5%.
Croatian: Ekstrapiramidni simptomi uglavnom su prijavljeni tijekom faze stabilizacije u 17 % bolesnika, pri čemu se u 6,5% bolesnika pojavio i tremor.
English: Blood pressure-lowering medicines: Aripiprazole Zentiva may increase the effect of medicines used to lower the blood pressure.
Croatian: Zentiva može pojačati učinak lijekova koji se koriste za snižavanje krvnog tlaka.
English: Treatment should be initiated at 2 mg (using an appropriate aripiprazole containing medicinal product) for 2 days, titrated to 5 mg for 2 additional days to reach the recommended daily dose of 10 mg.
Croatian: Liječenje treba započeti dozom od 2 mg (koristeći odgovarajući lijek koji sadrži aripiprazol) tijekom prva 2 dana, a potom titrirati do 5 mg tijekom sljedeća 2 dana kako bi se postigla preporučena dnevna doza od 10 mg.
English: Aripiprazole has minor to moderate influence on the ability to drive and use machines due to potential nervous system and visual effects, such as sedation, somnolence, syncope, vision blurred, diplopia (see section 4.8).
Croatian: Aripiprazol malo do umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima zbog mogućih učinaka na živčani i vidni sustav, kao što su sedacija, somnolencija, sinkopa, zamagljen vid, diplopija (vidjeti dio 4.8).
English: • Muscle stiffness, and drowsiness or sleepiness, slower breathing, choking, high or low blood pressure, abnormal rhythms of the heart.
Croatian: • ukočenosti mišića i omamljenosti ili pospanosti, usporeno disanje, gušenje, visok ili nizak krvni tlak, abnormalni srčani ritam.
English: Kaplan-Meier relapse rates at week 16 were 35% for aripiprazole and 52% for placebo; the hazard ratio for relapse within 16 weeks (aripiprazole/placebo) was 0.57 (non-statistically significant difference).
Croatian: Kaplan-Meierova stopa relapsa u 16. tjednu za bolesnike na aripiprazolu iznosila je 35 % dok je za one na placebu bila 52%; omjer hazarda relapsa u tih 16 tjedana (aripiprazol/placebo) bio je 0,57 (nije statistički značajna razlika).
English: • combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness and sudden changes in blood pressure and heart rate, fainting (neuroleptic malignant syndrome),
Croatian: • kombinacija vrućice, ukočenosti mišića, ubrzanog disanja, znojenja, smanjene svijesti i iznenadnih promjena krvnog tlaka i brzine otkucaja srca, nesvjestica (neuroleptički maligni sindrom),
English: All ADRs are listed by system organ class and frequency; very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data).
Croatian: Sve nuspojave navedene su prema klasifikaciji organskih sustava i učestalosti; vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (<1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
English: In three placebo-controlled trials (n = 938; mean age: 82.4 years; range: 56 - 99 years) of aripiprazole in elderly patients with psychosis associated with Alzheimer's disease, patients treated with aripiprazole were at increased risk of death compared to placebo.
Croatian: U tri placebom kontrolirana ispitivanja aripiprazola u starijih bolesnika (n = 938; srednja dob: 82,4 godine; raspon: 56-99 godina) s psihozom koja je bila povezana s Alzheimerovom bolešću, bolesnici liječeni aripiprazolom imali su povišen rizik od smrti u odnosu na bolesnike koji su primali placebo.
English: In a post-hoc analysis, the improvement over placebo was more pronounced in the patients with associated comorbidity of ADHD compared to the group without ADHD, where there was no difference from placebo.
Croatian: U post-hoc analizi je poboljšanje u odnosu na placebo bilo izraženije u bolesnika s ADHD-om kao povezanom popratnom bolešću nego u skupini koja nije imala ADHD i u kojoj nije primijećena razlika u odnosu na placebo.
English: The rate of death in aripiprazoletreated patients was 3.5% compared to 1.7% in the placebo group.
Croatian: Stopa smrti u bolesnika liječenih aripiprazolom bila je 3,5 % u usporedbi s 1,7 % u onih koji su primali placebo.
English: Manufacturer S.C. Zentiva S.A.
Croatian: S.C. Zentiva S.A.
English: Concomitant administration of aripiprazole and other inducers of CYP3A4 (such as rifampicin, rifabutin, phenytoin, phenobarbital, primidone, efavirenz, nevirapine and St. John's Wort) may be expected to have similar effects and similar dose increases should therefore be applied.
Croatian: Slični učinci mogu se očekivati i kod istodobne primjene aripiprazola i drugih induktora CYP3A4 (kao što su rifampicin, rifabutin, fenitoin, fenobarbital, primidon, efavirenz, nevirapin i gospina trava), pa se stoga moraju provesti slična povećanja doza.
English: The following symptoms may occur in newborn babies, of mothers that have used Aripiprazole Zentiva in the last trimester (last three months of their pregnancy): shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding.
Croatian: Sljedeći simptomi se mogu javiti u novorođenčadi majki koje su uzimale Aripiprazole Zentiva u posljednjem tromjesečju (posljednja tri mjeseca trudnoće): tresavica, ukočenost i/ili slabost mišića, pospanost, uznemirenost, tegobe s disanjem i poteškoće s hranjenjem.
English: Elevations of CPK (Creatine Phosphokinase), generally transient and asymptomatic, were observed in 3.5% of aripiprazole treated patients as compared to 2.0% of patients who received placebo.
Croatian: Povišenja vrijednosti CPK (kreatin fosfokinaze), općenito prolazne i asimptomatske naravi, bila su primijećena u 3,5 % bolesnika liječenih aripiprazolom u usporedbi s 2,0 % bolesnika koji su primili placebo.
English: Aripiprazole doses ranging from 0.5 to 30 mg administered once a day to healthy subjects for 2 weeks produced a dose-dependent reduction in the binding of 11C-raclopride, a D2/D3 receptor ligand,
Croatian: Doze aripiprazola u rasponu od 0,5 do 30 mg primijenjene jedanput dnevno u zdravih ispitanika tijekom 2 tjedna proizvele su o dozi ovisno smanjenje vezivanja 11C-rakloprida, liganda
English: Adjunctive aripiprazole demonstrated superiority over placebo on the secondary outcome measure, CGI-BP Severity of Illness score (mania).
Croatian: Adjuvantna terapija aripiprazolom pokazala se superiornom u odnosu na placebo u sekundarnoj mjeri ishoda, rezultatu na CGI-BP ljestvici težine bolesti (manija).
English: When appropriate, subsequent dose increases should be administered in 5 mg increments without exceeding the maximum daily dose of 30 mg (see section
Croatian: Po potrebi, doza se može dalje povećavati u koracima od po 5 mg, s time da se ne smije prekoračiti maksimalna dnevna doza od 30 mg (vidjeti dio 5.1).
English: According to the metabolic pathway of aripiprazole no dosage adjustment is required for smokers (see section 4.5).
Croatian: Pušenje S obzirom na metabolički put aripiprazola, nije potrebna prilagodba doze u pušača (vidjeti dio 4.5).
English: Pack size: 14, 28 or 49 orodispersible tablets
Croatian: Veličina pakiranja: 14, 28 ili 49 raspadljivih tableta za usta
English: In a pooled analysis on lipid parameters from placebo controlled clinical trials in adults, aripiprazole has not been shown to induce clinically relevant alterations in levels of total cholesterol, triglycerides, HDL and LDL.
Croatian: U objedinjenoj analizi lipidnih parametara prikupljenih u placebom kontroliranim ispitivanjima u odraslih bolesnika, nije se pokazalo da aripiprazol izaziva klinički značajne promjene razine ukupnog kolesterola, triglicerida, HDL-a i LDL-a.
English: The following adverse reactions had a possible dose response relationship; extrapyramidal disorder (incidences were 10 mg, 9.1%, 30 mg, 28.8%, placebo, 1.7%,); and akathisia (incidences were 10 mg, 12.1%, 30 mg, 20.3%, placebo, 1.7%).
Croatian: Sljedeće nuspojave mogle bi biti povezane s odgovorom na dozu: ekstrapiramidni poremećaj (incidencija je bila 9,1 % za dozu od 10 mg, 28,8 % za dozu od 30 mg i 1,7 % za placebo) i akatizija (incidencija je bila 12,1 % za dozu od 10 mg, 20,3 % za dozu od 30 mg i 1,7 % za placebo).
English: • life-threatening irregular heart beat,
Croatian: • za život opasni nepravilni otkucaji srca,
English: Aripiprazole Zentiva is used to treat adults and adolescents aged 13 years and older who suffer from a condition with symptoms such as feeling “high”, having excessive amounts of energy, needing much less sleep than usual, talking very quickly with racing ideas and sometimes severe irritability.
Croatian: Zentiva se koristi za liječenje odraslih osoba te adolescenata u dobi od 13 godina i starijih koji boluju od stanja čiji su simptomi “povišeno” raspoloženje, pretjerana količina energije, potreba za manjom količinom sna nego obično, vrlo brz govor i ubrzan tijek misli te ponekad teška razdražljivost.
English: Based on in vitro studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalysed by CYP3A4.
Croatian: Na temelju ispitivanja in vitro, zna se da su enzimi CYP3A4 i CYP2D6 odgovorni za dehidrogenaciju i hidroksilaciju aripiprazola, dok N-dealkilaciju katalizira enzim CYP3A4.
English: • Acute confusion, seizures (epilepsy), coma, a combination of fever, faster breathing, sweating,
Croatian: • akutnu smetenost, napadaje (epilepsiju), komu, kombinaciju vrućice, ubrzanog disanja,
English: Weight gain is commonly seen in schizophrenic and bipolar mania patients due to co-morbidities, use of antipsychotics known to cause weight gain, poorly managed life-style, and might lead to severe complications.
Croatian: Povećanje tjelesne težine uobičajeno je u bolesnika sa shizofrenijom i bipolarnom manijom zbog popratnih bolesti, uporabe antipsihotika koji uzrokuju debljanje i nezdravog načina života, a može dovesti do teških komplikacija.
English: • reports of abnormal liver tests values;
Croatian: • abnormalne vrijednosti jetrenih pretraga;
English: PHARMACEUTICAL FORM AND CONTENTS Orodispersible tablet
Croatian: OBLIK I SADRŽAJ Raspadljiva tableta za usta
English: Aripiprazole exhibited high binding affinity in vitro for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors and moderate affinity for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha-1 adrenergic and histamine H1 receptors.
Croatian: Aripiprazol je in vitro pokazao visok afinitet vezanja za dopaminske D2 i D3, serotoninske 5-HT1A i 5-HT2A receptore i umjeren afinitet za dopaminske D4, serotoninske 5-HT2C i 5-HT7, alfa-1 adrenergičke i histaminske H1 receptore.
English: Aripiprazole showed an improvement on TTS-YGTSS change from baseline to week 8 of 13.35 for the low dose group (5 mg or 10 mg) and 16.94 for the high dose group (10 mg or 20 mg) as compared with an improvement of 7.09 in the placebo group.
Croatian: Aripiprazol je pokazao poboljšanje na ljestvici TTS-YGTSS od početne vrijednosti do one u 8. tjednu od 13,35 bodova u skupini koja je primala nisku dozu (5 mg ili 10 mg) i 16,94 boda u skupini koja je primala visoku dozu (10 mg ili 20 mg) u usporedbi s poboljšanjem od 7,09 bodova u skupini koja je primala placebo.
English: Aripiprazole Zentiva tablets contain lactose.
Croatian: Aripiprazole Zentiva tablete sadrže laktozu.
English: • a fall in blood pressure on standing up which causes dizziness, light-headedness or fainting,
Croatian: • pad krvnog tlaka pri ustajanju koji uzrokuje vrtoglavicu, ošamućenost ili nesvjesticu,
English: Schizophrenia - in a long term 52-week controlled trial, aripiprazole-treated patients had an overalllower incidence (25.8%) of EPS including Parkinsonism, akathisia, dystonia and dyskinesia compared with those treated with haloperidol (57.3%).
Croatian: Shizofrenija - u dugotrajnom kontroliranom ispitivanju u trajanju od 52 tjedna, bolesnici liječeni aripiprazolom imali su nižu ukupnu incidenciju (25,8 %) EPS-a, uključujući parkinsonizam, akatiziju, distoniju i diskineziju, u usporedbi s onima liječenima haloperidolom (57,3 %).
English: In a 60- to 89-week, randomised, double-blind, placebo-controlled trial in adolescent subjects (n = 146; ages 13 - 17 years) with schizophrenia, there was a statistically significant difference in the rate of relapse of psychotic symptoms between the aripiprazole (19.39%) and placebo (37.50%) groups.
Croatian: U randomiziranom, dvostruko slijepom, placebom kontroliranom ispitivanju u trajanju od 60 do 89 tjedana u adolescentnih ispitanika (n = 146; u dobi od 13 do 17 godina) sa shizofrenijom postojala je statistički značajna razlika u stopi relapsa psihotičnih simptoma između skupine koja je primala aripiprazol (19,39 %) i skupine koja je primala placebo (37,50 %).