FrancophonIA/ELRC3.0 huggingface dataset:
English: Haematology Patients with baseline neutrophil counts of <1.5 x 10
Croatian: Hematologija Bolesnike s početnim brojem neutrofila <1,5 x 10
English: No significant differences occurred in the exposure to other metabolites (5'-DFCR, 5'-DFUR, and 5-FU).
Croatian: Nije bilo značajnih razlika u izloženosti drugim metabolitima (5'-DFCR, 5'-DFUR i 5-FU).
English: Care should be exercised when capecitabine is co-administered with 2C9 substrates (e.g., phenytoin).
Croatian: Potreban je oprez kada se kapecitabin primjenjuje istodobno sa supstratima 2C9 (npr. fenitoinom).
English: This increase is likely due to a change in renal function.
Croatian: Do tog povećanja vjerojatno dolazi zbog promijenjene funkcije bubrega.
English: When capecitabine and cisplatin are used in combination, the use of vitamin B6 (pyridoxine) is not advised for symptomatic or secondary prophylactic treatment of hand-foot syndrome, because of published reports that it may decrease the efficacy of cisplatin.
Croatian: Kada se kapecitabin i cisplatin primjenjuju u kombinaciji, ne preporučuje se uzimanje vitamina B6 (piridoksin) za simptomatsko liječenje ili sekundarnu profilaksu sindroma šaka-stopalo jer postoje izvješća da se tako može smanjiti djelotvornost cisplatina.
English: Allopurinol: interactions with allopurinol have been observed for 5-FU; with possible decreased efficacy of 5-FU.
Croatian: Interakcije s alopurinolom primijećene su za 5-FU, s mogućom smanjenom djelotvornošću 5-FU.
English: In combination with other medicines the usual dose for adults may be less than 1250 mg/m2 of body surface area, and you may need to take the tablets over a different time period (e.g. every day, with no rest period).
Croatian: U kombinaciji s drugim lijekovima uobičajena doza za odrasle može biti manje od 1250 mg/m tjelesne površine i moguće je da ćete uzimati tablete u različitom vremenskom razdoblju (npr. svaki dan, bez prekida).
English: Body System Very Common
Croatian: Organski sustav Vrlo često
English: During capecitabine monotherapy, no adjustment of the starting dose is needed.
Croatian: U monoterapiji kapecitabinom nije potrebna prilagodba početne doze.
English: In the event of grade 2-4 acute toxicity, treatment must be discontinued immediately.
Croatian: U slučaju akutne toksičnosti 2.-4. stupnja liječenje se mora odmah prekinuti.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP
English: STOP taking Ecansya immediately and contact your doctor if any of these symptoms occur: - Diarrhoea: if you have an increase of 4 or more bowel movements compared to your normal bowel movements each day or any diarrhoea at night.
Croatian: PRESTANITE odmah uzimati lijek Ecansya i obratite se liječniku ako se pojave neki od ovih simptoma: - proljev: ako se pražnjenje crijeva poveća za 4 ili više pražnjenja u usporedbi s normalnim svakodnevnim pražnjenjem crijeva ili ako imate proljev noću.
English: The Ecansya pivotal studies included females of childbearing potential and males only if they agreed to use an acceptable method of birth control to avoid pregnancy for the duration of the study and for a reasonable period thereafter.
Croatian: U pivotalna ispitivanja lijeka Ecansya žene reproduktivne dobi i muškarci uključeni su samo ako su pristali koristiti neku prihvatljivu metodu kontrole začeća kako bi izbjegli trudnoću tijekom trajanja ispitivanja i u razumnom razdoblju nakon toga.
English: All indications:
Croatian: Sve indikacije
English: Ecansya should be permanently discontinued in patients who experience a severe skin reaction during treatment.
Croatian: Primjenu lijeka Ecansya potrebno je trajno obustaviti u bolesnika koji razviju tešku kožnu reakciju tijekom liječenja.
English: The enzymes involved in the catalytic activation are found in tumour tissues but also in normal tissues, albeit usually at lower levels.
Croatian: Enzimi koji sudjeluju u katalitičkoj aktivaciji nalaze se u tumorskim tkivima, ali i u zdravim tkivima, iako obično u nižoj razini.
English: Other side-effects seen in this setting are the following:
Croatian: Ostale nuspojave primijećene u takvim okolnostima su:
English: Treatment with brivudine can be started 24 hours after the last dose of capecitabine.
Croatian: Liječenje brivudinom može se započeti 24 sata nakon posljednje doze kapecitabina.
English: Parameter: Overall Survival PPP
Croatian: Parametar: ukupno preživljenje PPP
English: Following a mean duration of follow-up for the study population of 26.2 months, treatment responses were as shown below:
Croatian: Odgovori na liječenje nakon razdoblja praćenja studijske populacije u srednjem trajanju od 26,2 mjeseca prikazani su ispod:
English: If the calculated creatinine clearance decreases during treatment to a value below 30 ml/min, Ecansya should be discontinued.
Croatian: Ako se izračunati klirens kreatinina smanji tijekom liječenja ispod 30 ml/min liječenje lijekom Ecansya treba prekinuti.
English: In vitro human plasma studies have determined that capecitabine, 5'-DFCR, 5'-DFUR and 5-FU are 54%, 10%, 62% and 10% protein bound, mainly to albumin.
Croatian: In vitro ispitivanja na ljudskoj plazmi pokazuju da su kapecitabin, 5'-DFCR, 5'-DFUR i 5-FU vezani za proteine 54%, 10%, 62% i 10%, i to većinom za albumin.
English: Dehydration should be prevented or corrected at the onset.
Croatian: Dehidraciju treba spriječiti ili korigirati čim se pojavi.
English: Capecitabine dose reduction decreases systemic exposure to 5-FU more than dose-proportionally, due to non-linear pharmacokinetics for the active metabolite.
Croatian: Smanjenje doze kapecitabina smanjuje sistemnu izloženost 5-FU-u više nego proporcionalno dozi, zbog nelinearne farmakokinetike aktivnoga metabolita.
English: ADRs are added according to the highest incidence seen in any of the major combination trials.
Croatian: Nuspojave su razvrstane prema najvišoj incidenciji zabilježenoj u bilo kojem od glavnih ispitivanja kombinacijske terapije.
English: There is evidence that the metabolism of 5-FU in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid, thereby interfering with the synthesis of deoxyribonucleic acid (DNA).
Croatian: Postoje dokazi da u anaboličkom putu metabolizma 5-FU blokira reakciju metilacije deoksiuridilne kiseline u timidilnu kiselinu, interferirajući tako sa sintezom deoksiribonukleinske kiseline (DNK).
English: Interaction with other medicinal products
Croatian: Interakcije s drugim lijekovima
English: In all clinical trials, patients were instructed to administer capecitabine within 30 minutes after a meal.
Croatian: U svim kliničkim ispitivanjima bolesnici su bili upućeni da kapecitabin uzimaju najkasnije 30 minuta nakon jela.
English: The usual dose for adults is 1250 mg/m2 of body surface area taken two times daily (morning and evening).
Croatian: Uobičajena doza za odrasle iznosi 1250 mg/m2 tjelesne površine i uzima se dvaput dnevno (ujutro i navečer).
English: As this medicinal product contains anhydrous lactose as an excipient, patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Croatian: S obzirom da ovaj lijek sadržava kao pomoćnu tvar bezvodnu laktozu, bolesnici s rijetkim nasljednim poremećajem nepodnošenja galaktoze, potpunim nedostatkom laktaze ili malapsorpcijom glukoze i galaktoze ne bi smjeli uzimati ovaj lijek.
English: Not applicable *According to the National Cancer Institute of Canada Clinical Trial Group (NCIC CTG) Common Toxicity Criteria (version 1) or the Common Terminology Criteria for Adverse Events (CTCAE) of the Cancer Therapy Evaluation Program, US National Cancer Institute, version 4.0.
Croatian: *Prema općim kriterijima toksičnosti skupine za klinička ispitivanja Kanadskoga nacionalnog instituta za rak (National Cancer Institute of Canada Clinical Trial Group - NCIC CTG), verzija 1 ili uobičajenom nazivlju kriterija za štetne događaje prema programu evaluacije terapije karcinoma Američkog nacionalnog instituta za rak (Common Terminology Criteria for Adverse Events (CTCAE) of the Cancer Therapy Evaluation Program, US National Cancer Institute), verzija 4.0.
English: These results suggest an interaction, probably due to an inhibition of the cytochrome P450 2C9 isoenzyme system by capecitabine.
Croatian: Ovi rezultati ukazuju na interakciju koja je vjerojatno posljedica inhibicije izoenzimskog sustava citokroma P450 2C9 kapecitabinom.
English: Japanese patients had also about 25% lower Cmax and 34% lower AUC for FBAL than Caucasian patients.
Croatian: Japanci su također imali 25% niži Cmax i 34% niži AUC FBAL-a nego bijelci.
English: The AUC0- values in g•h/ml were 7.75, 7.24, 24.6, 2.03 and 36.3.
Croatian: Vrijednosti AUC0- u g•sat/ml iznosile su 7,75; 7,24; 24,6; 2,03 i 36,3.
English: Toxicity grades* Dose changes within a treatment cycle Dose adjustment for next cycle/dose (% of starting dose)
Croatian: Prilagodba doze u sljedećem ciklusu/dozi (% početne doze)
English: Ecansya has minor or moderate influence on the ability to drive and use machines.
Croatian: Ecansya malo ili umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Since current safety and efficacy data are based upon administration with food, it is recommended that capecitabine be administered with food.
Croatian: Budući da se postojeći podaci o sigurnosti i djelotvornosti lijeka temelje na primjeni lijeka s hranom, preporučuje se da se kapecitabin uzima s hranom.
English: Hypo- or hypercalcaemia has been reported during capecitabine treatment.
Croatian: Hipokalcijemija ili hiperkalcijemija je zabilježena tijekom liječenja kapecitabinom.
English: The patients who are tested negative for the above-mentioned alleles may still have a risk of severe adverse events.
Croatian: U bolesnika s negativnim nalazima testa na navedene alele ipak može biti prisutan rizik od teških štetnih događaja.
English: An effective method of contraception should be used during treatment and for 6 months after the last dose of capecitabine.
Croatian: Potrebno je primjenjivati učinkovitu metodu kontracepcije tijekom liječenja i još 6 mjeseci nakon posljednje doze kapecitabina.
English: For patients 60 years of age or more, a starting dose reduction of capecitabine to 75% (950 mg/m2 twice daily) is recommended.
Croatian: Bolesnicima u dobi od 60 ili više godina preporučuje se smanjenje početne doze kapecitabina na 75% (950 mg/m2 dvaput dnevno).
English: Ecansya tablets should be swallowed whole with water within 30 minutes after a meal.
Croatian: Ecansya tablete moraju se progutati cijele s vodom najkasnije 30 minuta nakon obroka.
English: ( 1/100 to < 1/10), uncommon ( 1/1,000 to < 1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000).
Croatian: Za klasifikaciju nuspojava prema učestalosti koriste se sljedeće oznake: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000) i vrlo rijetko (< 1/10 000).
English: HR (97.5% CI)
Croatian: omjer hazarda (97,5% CI)
English: Patients with low or absent DPD activity, an enzyme involved in fluorouracil degradation, are at increased risk for severe, life-threatening, or fatal adverse reactions caused by fluorouracil.
Croatian: Bolesnici s niskom aktivnošću ili izostankom aktivnosti DPD-a, enzima koji sudjeluje u razgradnji fluorouracila, imaju povećan rizik od teških, po život opasnih ili smrtonosnih nuspojava koje uzrokuje fluorouracil.
English: The time to peak plasma concentrations (Tmax in hours) were 1.50, 2.00, 2.00, 2.00 and 3.34.
Croatian: Vrijeme potrebno za postizanje vršne koncentracije u plazmi (Tmax u satima) iznosilo je 1,50; 2,00; 2,00; 2,00 i 3,34.
English: Toxicity due to capecitabine administration may be managed by symptomatic treatment and/or modification of the dose (treatment interruption or dose reduction).
Croatian: Toksičnost koja se javlja kao posljedica liječenja kapecitabinom moguće je kontrolirati simptomatskim liječenjem i/ili prilagodbom doze (prekid liječenja ili smanjenje doze).
English: The enhanced toxicity may be relevant when switching from 5-FU/LV to a capecitabine regimen.
Croatian: Povećana toksičnost može biti važna pri prelasku s 5-FU/LV na protokole koji sadrže kapecitabin.
English: Dose limiting toxicities
Croatian: Toksičnost koja ograničava dozu
English: It is therefore possible that Ecansya could affect your ability to drive a car or operate machines.
Croatian: Stoga postoji mogućnost da Ecansya utječe na sposobnost upravljanja vozilima i strojevima.
English: Two examples are provided here: A person whose body weight is 64 kg and height is 1.64 m has a body surface area of 1.7 m2 and should take 4 tablets of 500 mg and 1 tablet of 150 mg two times daily.
Croatian: Ovdje su navedena dva primjera: osoba čija tjelesna težina iznosi 64 kg, a visina 1,64 m, ima tjelesnu površinu od 1,7 m2 te mora uzimati 4 tablete od 500 mg i 1 tabletu od 150 mg dvaput dnevno.
English: 12.1 months
Croatian: 12,1 mjesec
English: At the end of treatment, 37% of patients in the XELIRI and 26% of patients in the FOLFIRI arm were without evidence of the disease (p=0.56).
Croatian: Na kraju liječenja 37% bolesnika koji su primali XELIRI i 26% bolesnika koji su primali FOLFIRI nisu imali znakova bolesti (p=0,56).
English: If grade 2 (or higher) dehydration occurs, capecitabine treatment should be immediately interrupted and the dehydration corrected.
Croatian: Ako se razvije dehidracija 2. stupnja (ili višeg), potrebno je odmah prekinuti liječenje kapecitabinom i nadoknaditi tekućinu.
English: Dehydration may cause acute renal failure, especially in patients with pre-existing compromised renal function or when capecitabine is given concomitantly with known nephrotoxic medicinal products.
Croatian: Dehidracija može izazvati akutno zatajenje bubrega, osobito u bolesnika s otprije kompromitiranom bubrežnom funkcijom ili kada se kapecitabin daje istodobno s poznatim nefrotoksičnim lijekovima.
English: It has been reported that the DPYD*2A, c.1679T>G variants lead to a greater reduction in enzymatic activity than the other variants with a higher risk of side effects.
Croatian: Postoje izvješća o tome da varijante DPYD*2A i c.1679T>G uzrokuju veće smanjenje enzimske aktivnosti nego druge varijante, uz veći rizik od nuspojava.
English: See leaflet for further information.
Croatian: Vidjeti uputu o lijeku za dodatne informacije.
English: For those toxicities considered by the treating physician to be unlikely to become serious or life-threatening, e.g. alopecia, altered taste, nail changes, treatment can be continued at the same dose without reduction or interruption.
Croatian: Kod pojave toksičnih reakcija za koje liječnik koji provodi liječenje smatra da vjerojatno neće postati ozbiljne ili opasne po život, primjerice kod alopecije, poremećaja okusa ili promjena na noktima, liječenje se može nastaviti istom dozom bez njenog smanjenja ili prekida liječenja.
English: The effects of DNA and RNA deprivation are most marked on those cells which proliferate more rapidly and which metabolise 5-FU at a more rapid rate.
Croatian: Učinci gubitka DNK i RNK najuočljiviji su na onim stanicama koje se najbrže dijele i koje brže metaboliziraju 5-FU.
English: The XELIRI has been compared with 5-FU + irinotecan (FOLFIRI) in three randomised studies in patients with metastatic colorectal cancer.
Croatian: XELIRI protokol uspoređen je s kombinacijom 5-FU + irinotekan (FOLFIRI protokol) u tri randomizirana ispitivanja u bolesnika s metastatskim kolorektalnim karcinomom.
English: + For each term, the frequency count was based on ADRs of all grades.
Croatian: Za svaki pojam učestalost se temeljila na nuspojavama svih stupnjeva.
English: Careful monitoring and prompt treatment interruption is recommended if the patient develops a grade 2, 3 or 4 adverse event during treatment and subsequent dose adjustment as outlined in table 3 above.
Croatian: Pažljivo praćenje i odgovarajući prekid liječenja preporučuju se u slučaju bolesnika koji razviju nuspojave 2., 3. ili 4. stupnja tijekom liječenja, nakon čega slijedi prilagodba daljnjih doza kako je navedeno u Tablici
English: However, similar to other nucleoside analogues (ie, 5-FU), capecitabine was clastogenic in human lymphocytes (in vitro) and a positive trend occurred in mouse bone marrow micronucleus tests (in vivo).
Croatian: Međutim, kao i ostali analozi nukleozida (5-FU), kapecitabin je imao klastogeni učinak na ljudske limfocite (in vitro), a uočen je pozitivni trend u mikronuklearnim testovima (in vivo) na koštanoj srži miša.
English: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Croatian: Ako Vam je liječnik rekao da ne podnosite neke šećere, savjetujte se s liječnikom prije uzimanja ovog lijeka.
English: Within each frequency grouping, ADRs are presented in order of decreasing seriousness.
Croatian: Unutar svake od tih kategorija nuspojave su navedene u padajućem nizu prema ozbiljnosti.
English: There is insufficient data to recommend a specific dose in patients with partial DPD activity as measured by specific test.
Croatian: Podaci za preporučenu specifičnu dozu kod bolesnika s djelomičnom aktivnošću DPD-a mjerenom specifičnim testovima su nepotpuni.
English: Diabetes mellitus or electrolyte disturbances.
Croatian: Šećerna bolest ili poremećaji elektrolita
English: Posology adjustments during treatment
Croatian: Prilagodba doze tijekom liječenja
English: - first-line treatment of advanced gastric cancer in combination with a platinum based regimen (see section 5.1).
Croatian: - za prvu liniju liječenja uznapredovalog karcinoma želuca u kombinaciji s protokolom temeljenim na platini (vidjeti dio 5.1).
English: See also interaction with coumarin-derivative anticoagulants below, and section 4.4.
Croatian: Vidjeti i interakcije s kumarinskim antikoagulansima u nastavku te dio 4.4.
English: If you have taken brivudine you must wait for at least 4 weeks after stopping brivudine before starting to take capecitabine.
Croatian: Ako ste uzimali brivudin, morate pričekati najmanje 4 tjedna od završetka liječenja brivudinom do početka liječenja kapecitabinom.
English: Capecitabine was not mutagenic in vitro to bacteria (Ames test) or mammalian cells (Chinese hamster V79/HPRT gene mutation assay).
Croatian: Kapecitabin nije bio mutagen in vitro za bakterijske stanice (Amesov test) ili stanice sisavaca (V79/HPRT test genske mutacije na modelu kineskog hrčka).
English: Therefore, brivudine must not be administered concomitantly with capecitabine (see section 4.3 and 4.4).
Croatian: Stoga se brivudin ne smije primjenjivati istodobno s kapecitabinom (vidjeti dijelove 4.3 i 4.4).
English: Rigors, Body temperature increased ** Based on the post-marketing experience, persistent or severe palmar-plantar erythrodysaesthesia syndrome can eventually lead to loss of fingerprints (see section 4.4.)
Croatian: **Na temelju iskustva nakon stavljanja lijeka u promet, perzistirajući ili težak sindrom palmarno-plantarne eritrodizestezije može naposljetku dovesti do gubitka otisaka prstiju (vidjeti dio 4.4).
English: Gender, presence or absence of liver metastasis at baseline, Karnofsky Performance Status, total bilirubin, serum albumin, ASAT and ALAT had no statistically significant effect on the pharmacokinetics of 5'-DFUR, 5-FU and FBAL.
Croatian: Spol, postojanje ili nepostojanje jetrenih metastaza na početku liječenja, opći status po Karnofskom, ukupni bilirubin, serumski albumin, AST i ALT nisu imali statistički značajan učinak na farmakokinetiku 5'-DFUR, 5FU i FBAL.
English: In addition to the above, when Ecansya is used alone, very common side effects, which may affect more than 1 in 10 people are: - abdominal pain - rash, dry or itchy skin - tiredness - loss of appetite (anorexia)
Croatian: Uz prethodno navedene, kada se Ecansya primjenjuje samostalno, vrlo česte nuspojave koje se mogu javiti u više od 1 na 10 osoba su: - bol u trbuhu - osip, suha koža ili svrbež - umor - gubitak apetita (anoreksija)
English: The inclusion of bevacizumab in a combination regimen has no effect on the starting dose of capecitabine.
Croatian: Primjena bevacizumaba u kombinacijskom protokolu ne utječe na početnu dozu kapecitabina.
English: What you need to know before you take Ecansya
Croatian: Što morate znati prije nego počnete uzimati lijek Ecansya
English: If caught early, these side effects usually improve within 2 to 3 days after treatment discontinuation.
Croatian: Ako se zamijete u ranoj fazi, te se nuspojave povlače unutar 2 do 3 dana nakon prestanka liječenja.
English: 150 mg 300 mg 500 mg Dose per administration (mg)
Croatian: 150 mg 300 mg 500 mg Doza po jednoj primjeni (mg)
English: The median follow up at the time of the primary analyses in the intent-to-treat population was 1.5 years; data from analyses following an additional 1 year of follow up are also included in table 7.
Croatian: Medijan praćenja u vrijeme primarnih analiza u populaciji bolesnika predviđenih za liječenje bio je 1,5 godinu; podaci iz analiza nakon još jedne dodatne godine praćenja također su sadržani u Tablici 7.
English: FOLFOX-4 or FOLFOX-4 + Bevacizumab
Croatian: FOLFOX-4 ili FOLFOX-4 i bevacizumab oksaliplatin
English: However this was associated with an increased incidence of gastrointestinal toxicity and neutropenia during first-line treatment with XELIRI (26% and 11% for XELIRI and first line capecitabine respectively).
Croatian: Međutim, ovo je bilo povezano s povećanom incidencijom gastrointestinalne toksičnosti i neutropenije tijekom prvolinijskog liječenja XELIRI protokolom (26% uz XELIRI protokol i 11% kod prvolinijskog liječenja kapecitabinom).
English: Administration with food decreases the rate of capecitabine absorption, but only results in a minor effect on the AUC of 5'-DFUR, and on the AUC of the subsequent metabolite 5-FU.
Croatian: Primjena s hranom smanjuje brzinu apsorpcije kapecitabina, ali ima samo mali učinak na AUC 5'-DFUR, odnosno na AUC metabolita 5-FU.
English: The enzyme involved in the final conversion to 5-FU, thymidine phosphorylase (ThyPase), is found in tumour tissues, but also in normal tissues, albeit usually at lower levels.
Croatian: Enzim uključen u završnu konverziju u 5-FU, timidin fosforilaza (ThyPase), nađen je u tumorskom tkivu, ali i u zdravim tkivima, iako obično u nižoj razini.
English: There is no data on Ecansya and impact on fertility.
Croatian: Nema podataka o utjecaju lijeka Ecansya na plodnost.
English: After oral administration, capecitabine is rapidly and extensively absorbed, followed by extensive conversion to the metabolites, 5'-DFCR and 5'-DFUR.
Croatian: Nakon oralne primjene kapecitabin se brzo i ekstenzivno apsorbira, nakon čega slijedi ekstenzivna konverzija u metabolite 5'-DFCR i 5'-DFUR.
English: Administration with food decreases the rate of capecitabine absorption (see section 5.2).
Croatian: Primjena s hranom smanjuje brzinu apsorpcije kapecitabina (vidjeti dio 5.2).
English: Children and adolescents Ecansya is not indicated in children and adolescents.
Croatian: Ecansya nije namijenjena za primjenu u djece i adolescenata.
English: Patients were randomised to receive either FOLFIRI plus bevacizumab (Arm-A, n=167) or XELIRI plus bevacizumab (Arm-B, n-166).
Croatian: Bolesnici su randomizirani da primaju ili FOLFIRI + bevacizumab (skupina A, n=167) ili XELIRI + bevacizumab (skupina B, n=166).
English: The following covariates were statistically significantly associated with a decreased risk of developing diarrhoea: increasing cumulative capecitabine dose (0.1*kg) and increasing relative dose intensity in the first six weeks.
Croatian: Sljedeći nezavisni čimbenici su bili statistički značajno povezani sa smanjenim rizikom pojave proljeva: povećana kumulativna doza kapecitabina (0,1*kg) i povećanje intenziteta relativne doze u prvih šest tjedana.