FrancophonIA/ELRC3.0 huggingface dataset:
English: Common: Bradycardia**; atrial flutter** Uncommon: Sinus arrest; ventricular tachycardia; palpitations; bundle branch block left; ventricular extrasystoles; AV block first degree; AV block complete; bundle branch block right; sinus bradycardia; ECG QRS complex prolonged; cardiogenic shock
Croatian: Manje često: sinusni arest; ventrikularna tahikardija; palpitacije; blok lijeve grane; ventrikularne ekstrasistole; AV-blok prvog stupnja;
English: Patients with renal impairment: No dose adjustment necessary (see section 5.2).
Croatian: Nije potrebno prilagođavati dozu (vidjeti dio 5.2).
English: BRINAVESS 20 mg/ml concentrate for solution for infusion
Croatian: BRINAVESS 20 mg/ml koncentrat za otopinu za infuziju
English: How to use BRINAVESS
Croatian: Kako čuvati BRINAVESS
English: Read carefully the Summary of Product Characteristics and the Health Care Professional Information Card prior to the administration of BRINAVESS
Croatian: Prije primjene lijeka BRINAVESS pažljivo pročitajte Sažetak opisa svojstava lijeka i Karticu s informacijama za zdravstvene radnike
English: Patients with a history of CHF showed a higher incidence of ventricular arrhythmia in the first two hours post dose (6.4% for vernakalant compared to 1.6% in placebo).
Croatian: Bolesnici s anamnezom kongestivnog zatajenja srca imali su veću incidenciju ventrikularne aritmije u prva 2 sata nakon primjene lijeka (6,4% za vernakalant u odnosu na 1,6% za placebo).
English: • Patients with severe aortic stenosis, patients with systolic blood pressure < 100 mm Hg, and patients with heart failure class NYHA III and NYHA IV. - Alert HCP about BRINAVESS special warnings and precautions in patients with, clinically meaningful valvular stenosis, hypertrophic obstructive cardiomyopathy, restrictive cardiomyopathy, or constrictive pericarditis, previously documented LVEF ≤ 35 %, advanced hepatic impairment.
Croatian: - Upozorenje zdravstvenim radnicima o posebnim upozorenjima i mjerama opreza u bolesnika s klinički značajnom stenozom srčanog zaliska, hipertrofičnom opstruktivnom kardiomiopatijom, restriktivnom kardiomiopatijom ili konstriktivnim perikarditisom, prethodno dokumentiranom ejekcijskom frakcijom lijevog ventrikula (LVEF) ≤ 35%, uznapredovalim oštećenjem funkcije jetre.
English: Risk of atrial flutter may be increased in patients receiving class I AADs (see above).
Croatian: I mogu imati povećan rizik za undulaciju atrija (vidjeti u gornjem tekstu).
English: If you think that you may have been given too much BRINAVESS, tell your doctor straight away.
Croatian: Ako primite više lijeka BRINAVESS nego što ste trebali Ako mislite da ste možda primili previsoku dozu lijeka BRINAVESS, o tome odmah obavijestite liječnika.
English: Patients should be frequently monitored for the duration of the infusion and for at least 15 minutes after the completion of the infusion for signs and symptoms of a sudden decrease in blood pressure or heart rate.
Croatian: Bolesnike se mora učestalo nadzirati za vrijeme trajanja infuzije i još najmanje 15 minuta nakon njezina završetka kako bi se uočili eventualni znakovi i simptomi iznenadnog pada krvnog tlaka ili srčane frekvencije.
English: If conversion to sinus rhythm does not occur within 15 minutes after the end of the initial infusion, a second 10-minute infusion of 226 mg (56.5 ml of 4 mg/ml solution) may be administered.
Croatian: Ako unutar 15 minuta od završetka početne infuzije ne nastupi konverzija u sinusni ritam, može se primijeniti druga infuzija u dozi od 226 mg (56,5 ml otopine koncentracije 4 mg/ml) tijekom 10 minuta.
English: Uncommon: Dyspnoea; throat irritation; oropharyngeal pain; nasal congestion; suffocation feeling; choking sensation; rhinorrhoea Gastrointestinal disorders Common: Nausea; paraesthesia oral; vomiting Uncommon: Dry mouth; diarrhoea; hypoaesthesia oral; defecation urgency
Croatian: Manje često: dispneja; iritacija grla; orofaringealna bol; kongestija nosa; osjećaj gušenja; osjet gušenja; rinoreja
English: Fertility Vernakalant was not shown to alter fertility in animal studies.
Croatian: Istraživanja na životinjama nisu pokazala da vernakalant utječe na plodnost.
English: BRINAVESS contains the active substance vernakalant hydrochloride.
Croatian: Što je BRINAVESS i za što se koristi BRINAVESS sadrži djelatnu tvar vernakalantklorid.
English: Has the patient received an intravenous rhythm control antiarrhythmic drug (class I and/or class III) within 4 hours of the time when BRINAVESS will be infused?
Croatian: Je li bolesnik primio intravenski antiaritmik (skupine I i/ili III) za kontrolu srčanog ritma unutar 4 sata prije predviđene infuzije lijeka BRINAVESS?
English: Patients with CHF showed a higher overall incidence of hypotensive events, during the first 2 hours after dose in patients treated with vernakalant compared to patients receiving placebo (13.4 % versus 4.7 %, respectively).
Croatian: Kod bolesnika s kongestivnim zatajenjem srca je ukupna incidencija hipotenzivnih epizoda u prva 2 sata nakon primjene lijeka bila veća u bolesnika liječenih vernakalantom (13,4 %) nego u bolesnika koji su primali placebo (4,7 %).
English: These effects, seen within 24 hours of being given BRINAVESS, should pass quickly, however, if they do not you should consult your doctor.
Croatian: Ovi bi učinci, opaženi unutar 24 sata od primjene lijeka BRINAVESS, trebali ubrzo nestati.
English: • Use of intravenous rhythm control antiarrhythmics (class I and class III) within 4 hours prior to, as well as in the first 4 hours after, BRINAVESS administration.
Croatian: • Intravenska primjena antiaritmika za kontrolu srčanog ritma (skupine I i III) unutar 4 sata prije kao i u prva 4 sata nakon primjene lijeka BRINAVESS.
English: BRINAVESS 20 mg/ml concentrate for solution for infusion vernakalant hydrochloride
Croatian: BRINAVESS 20 mg/ml koncentrat za otopinu za infuziju vernakalantklorid
English: In adults it is used if you have a fast, irregular heart beat called atrial fibrillation which has started recently, less than or equivalent to 7 days, for non-surgery patients and less than or equivalent to 3 days for post-cardiac surgery patients.
Croatian: koja se u bolesnika koji nisu operirani pojavila nedavno, prije 7 dana ili manje, a u bolesnika nakon operacije srca prije 3 dana ili manje.
English: • numbness or tingling that occurs in the mucosa or tissues of the oral cavity
Croatian: • utrnulost ili trnci u sluznici ili tkivima usne šupljine
English: However, acute intravenous administration of vernakalant is not expected to markedly impact the PK of chronically administered 2D6 substrates, as a consequence of vernakalant's short half-life and the ensuing transient nature of 2D6 inhibition.
Croatian: Međutim, zbog kratkog poluvijeka vernakalanta te time uvjetovane prolazne inhibicije 2D6, ne očekuje se da će akutna intravenska primjena vernakalanta značajno utjecati na farmakokinetiku dugotrajno primjenjivanih supstrata enzima 2D6.
English: Prior to administration the prescriber is asked to determine eligibility of the patient through use of the supplied checklist.
Croatian: Liječnik koji propisuje lijek mora prije primjene uz pomoć kontrolnog upitnika utvrditi je li bolesnik podoban za liječenje.
English: Each ml of concentrate contains 20 mg vernakalant hydrochloride equivalent to 18.1 mg vernakalant.
Croatian: Jedan ml koncentrata sadrži 20 mg vernakalantklorida, što odgovara 18,1 mg vernakalanta.
English: Each 25 ml vial contains 500 mg of vernakalant hydrochloride equivalent to 452.5 mg of vernakalant.
Croatian: Jedna bočica od 25 ml sadrži 500 mg vernakalantklorida, što odgovara 452,5 mg vernakalanta.
English: BRINAVESS must be diluted before it is used.
Croatian: BRINAVESS se prije primjene mora razrijediti.
English: • coughing, sore nose
Croatian: • curenje iz nosa, grlobolja
English: Common: Infusion site pain; feeling hot; infusion site paraesthesia Uncommon: Fatigue; infusion site irritation; infusion site hypersensitivity; infusion site pruritus; malaise
Croatian: Manje često: umor; iritacija na mjestu primjene infuzije; preosjetljivost na mjestu primjene infuzije; pruritus na mjestu primjene infuzije; malaksalost
English: • BRINAVESS should be used with caution in patients on oral AADs (class I and III), due to limited experience.
Croatian: • Zbog ograničenog iskustva BRINAVESS treba primjenjivati uz oprez u bolesnika koji uzimaju oralne antiaritmike (skupine I i III).
English: If the patient was in atrial fibrillation or atrial flutter at the end of the 15-minute observation period, a second 10-minute infusion of 2.0 mg/kg BRINAVESS (or matching placebo) was administered.
Croatian: Ako je bolesnik imao fibrilaciju atrija ili undulaciju atrija na kraju 15-minutnog razdoblja promatranja, primijenjena je druga 10-minutna infuzija lijeka
English: However, blockade of cationic currents, including hERG channels and cardiac voltage-dependent sodium channels, which are present in the ventricles has been documented.
Croatian: Međutim, zabilježena je i blokada protoka kationa prisutnih u ventrikulima,
English: • stuffy nose
Croatian: • suha usta
English: Valvular heart disease
Croatian: • bolest srčanih zalistaka
English: Vernakalant should be used with caution in patients on oral AADs (class I and III), due to limited experience.
Croatian: Zbog ograničenog iskustva vernakalant treba primjenjivati uz oprez u bolesnika koji uzimaju oralne antiaritmike (skupine I i III).
English: One patient who received 3 mg/kg of vernakalant over 5 minutes (instead of the recommended 10 minutes) developed haemodynamically stable wide complex tachycardia which resolved without sequelae.
Croatian: Jedan bolesnik koji je primio dozu od 3 mg/kg vernakalanta tijekom 5 minuta (umjesto preporučenih
English: Each vial contains 500 mg vernakalant hydrochloride equivalent to 452.5 mg vernakalant.
Croatian: Jedna bočica sadrži 500 mg vernakalantklorida, što odgovara 452,5 mg vernakalanta.
English: • feeling hot
Croatian: • osjećaj gušenja
English: Sodium hydroxide (E524) (for pH-adjustment)
Croatian: FARMACEUTSKI PODACI 6.1 Popis pomoćnih tvari citratna kiselina (E330) natrijev klorid voda za injekcije natrijev hidroksid (E524) (za podešavanje pH)
English: Do not use BRINAVESS if you take certain other intravenous medicines (antiarrhythmics Class I and III) used to normalize an abnormal heart rhythm, 4 hours before BRINAVESS is to be used.
Croatian: Nemojte primjenjivati BRINAVESS ako 4 sata prije nego što trebate primiti BRINAVESS primite neke druge lijekove u venu (antiaritmike skupine I ili III) za normalizaciju poremećenog srčanog ritma.
English: • taste disturbances
Croatian: • poremećaj osjeta okusa • kihanje
English: This will be a slightly lower dose of 2 mg/kg, with a maximum calculated dose based upon 113 kg. Total doses of greater than 5 mg/kg should not be administered within 24 hours.
Croatian: To će biti nešto niža doza od 2 mg/kg, a najviša dopuštena doza izračunata je na temelju bolesnika tjelesne težine 113 kg.
English: 25 mL:1 vial 500 mg/25 ml
Croatian: 1 bočica 500 mg/25 ml
English: -For non-surgery patients: atrial fibrillation ≤ 7 days duration -For post-cardiac surgery patients: atrial fibrillation ≤ 3 days duration
Croatian: Brza konverzija nedavno nastale fibrilacije atrija u sinusni ritam u odraslih bolesnika: - u bolesnika koji nisu operirani: fibrilacija atrija koja traje ≤ 7 dana
English: Create a solution with a concentration of 4 mg/ml following the dilution guidelines below: Patients ≤ 100 kg: 25 ml of BRINAVESS 20 mg/ml is added to 100 ml of diluent.
Croatian: Bolesnici ≤ 100 kg: 25 ml lijeka BRINAVESS 20 mg/ml dodaje se u 100 ml otopine za razrjeđivanje.
English: • Use of intravenous rhythm control antiarrhythmics (class I and class III) within 4 hours prior to,
Croatian: • Intravenska primjena antiaritmika za kontrolu srčanog ritma (skupine I i III) unutar 4 sata prije kao i u prva 4 sata nakon primjene vernakalanta.
English: Risk of atrial flutter may be increased in patients receiving class I AADs.
Croatian: I mogu imati povećan rizik za undulaciju atrija.
English: Table 1: Adverse reactions with BRINAVESS *
Croatian: Tablica 1: Nuspojave lijeka BRINAVESS * Poremećaji živčanog sustava
English: If you get any side effects, talk to your doctor.
Croatian: Ako ne nestanu, obratite se svom liječniku.
English: Efficacy in patients with sustained atrial fibrillation, (ACT I and ACT III) Primary efficacy endpoint was the proportion of subjects with short duration atrial fibrillation (3 hours to 7 days) who had a treatment-induced conversion of atrial fibrillation to sinus rhythm for a minimum duration of one minute within 90 minutes of first exposure to study drug.
Croatian: (3 sata do 7 dana) u kojih se terapijom u roku od 90 minuta od prve izloženosti ispitivanom lijeku postigla konverzija fibrilacije atrija u sinusni ritam u trajanju od najmanje jedne minute.
English: Name and address of the manufacturer responsible for batch release
Croatian: PROIZVOĐAČ ODGOVORAN ZA PUŠTANJE SERIJE LIJEKA U PROMET Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet Geodis Logistics Netherlands B.V.
English: • liver problems
Croatian: • tegobe s jetrom
English: Common: Hypotension Uncommon: Flushing; hot flush; pallor
Croatian: Često: hipotenzija Manje često: crvenilo praćeno osjećajem vrućine; navale vrućine;
English: Use of AADs (antiarrhythmic drugs) prior to or after vernakalant Vernakalant cannot be recommended in patients previously administered intravenous AADs (class I and III) 4-24 hours prior to vernakalant, due to lack of data.
Croatian: Vernakalant se zbog nedostatka podataka ne može preporučiti za bolesnike koji su 4 do 24 sata prije primjene vernakalanta intravenski primili antiaritmike (skupine I i III).
English: Please refer to the Summary of Product Characteristics and the educational material for additional information prior to the use of BRINAVESS
Croatian: Sljedeće informacije namijenjene su samo zdravstvenim radnicima: Za dodatne informacije prije primjene lijeka BRINAVESS pročitajte Sažetak opisa svojstava lijeka i materijal za edukaciju.
English: Each vial contains 200 mg vernakalant hydrochloride equivalent to 181 mg vernakalant.
Croatian: Jedna bočica sadrži 200 mg vernakalantklorida, što odgovara 181 mg vernakalanta.
English: Each 10 ml vial contains 200 mg of vernakalant hydrochloride equivalent to 181 mg of vernakalant.
Croatian: Jedna bočica od 10 ml sadrži 200 mg vernakalantklorida, što odgovara 181 mg vernakalanta.
English: 200 mg/10 ml
Croatian: 200 mg/10 ml 25 ml:
English: Each vial of 500 mg of vernakalant hydrochloride is equivalent to 452.5 mg of vernakalant.
Croatian: Jedna bočica od 500 mg vernakalantklorida odgovara 452,5 mg vernakalanta.
English: In patients with uncorrected hypokalaemia (serum potassium of less than 3.5 mmol/l), potassium levels should be corrected prior to use of vernakalant.
Croatian: U bolesnika s nekorigiranom hipokalijemijom (koncentracija kalija u serumu niža od
English: Each vial of 200 mg vernakalant hydrochloride is equivalent to 181 mg vernakalant.
Croatian: Jedna bočica od 200 mg vernakalantklorida odgovara 181 mg vernakalanta.
English: An infusion pump is the preferred delivery device.
Croatian: Lijek po mogućnosti treba primijeniti infuzijskom pumpom.
English: Step 1: BRINAVESS vials should be visually inspected for particulate matter and discolouration before administration.
Croatian: 1.korak: Prije primjene vizualno provjerite sadrži li bočica lijeka BRINAVESS vidljive čestice i je li došlo do promjene boje sadržaja.
English: How to store BRINAVESS
Croatian: Moguće nuspojave Kako čuvati BRINAVESS
English: Direct-current cardioversion may be considered for patients who do not respond to therapy.
Croatian: U bolesnika koji ne odgovaraju na terapiju može se razmotriti kardioverzija istosmjernom strujom (DC kardioverzija).
English: The following information is intended for healthcare professionals only:
Croatian: Materijal za edukaciju zdravstvenih radnika
English: • sneezing
Croatian: SN:
English: Correvio Tel.: +41 848 00 79 70
Croatian: Correvio Тел.: +41 848 00 79 70
English: Common: Cough; nasal discomfort
Croatian: Često: kašalj; nelagoda u nosu
English: Fibrillation
Croatian: Plodnost
English: • nausea and vomiting
Croatian: • mučnina i povraćanje • osjećaj vrućine
English: ANNEX II A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
Croatian: OSTALI UVJETI I ZAHTJEVI ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET • Periodička izvješća o neškodljivosti lijeka (PSUR-evi)
English: Post-cardiac surgery patients: No dose adjustment necessary.
Croatian: Bolesnici nakon kirurškog zahvata na srcu:
English: Co. Kerry,
Croatian: Kerry,
English: In addition, aggressive behaviour was observed.
Croatian: Osim toga, uočeno je i agresivno ponašanje.
English: Number of tablets per day
Croatian: Broj tableta na dan
English: Keep the bottle tightly closed in order to protect from moisture.
Croatian: Držati bocu čvrsto zatvorenu radi zaštite od vlage.
English: EXP {month/year} Once opened, use by….
Croatian: EXP {mjesec/godina} Jednom otvoren, primijeniti do...
English: If no improvement is noted within 4 weeks, case management should be re-evaluated.
Croatian: Ako se u roku od 4 tjedna ne primijeti poboljšanje, potrebno je ponovno procijeniti slučaj.
English: To minimize the risk of adverse reactions, the recommended dose should not be exceeded.
Croatian: Kako bi se smanjio rizik od neželjenih reakcija, preporučena se doza ne smije prekoračiti.
English: Lot {number}
Croatian: Lot > {broj}
English: Therefore, fluoxetine should be used with caution with other veterinary medicinal products.
Croatian: Zato fluoksetin treba oprezno koristiti s drugim veterinarsko-medicinskim proizvodima.
English: One bottle per carton.
Croatian: Jedna boca po kutiji.
English: Discard any tablets remaining 30 days after opening.
Croatian: Bacite sve tablete koje preostanu 30 dana nakon otvaranja.
English: Interaction with other medicinal products and other forms of interaction:
Croatian: Interakcije s drugim medicinskim proizvodima i drugi oblici interakcije:
English: Do not store above 30 °C.
Croatian: Ne čuvati iznad 30°C.
English: Fluoxetine does not act as a sedative.
Croatian: Fluoksetin ne djeluje kao sedativ.
English: This product should only be used in conjunction with a behaviour modification programme recommended by your veterinary surgeon.
Croatian: Ovaj proizvod treba koristiti samo u kombinaciji s programom za promjenu ponašanja po preporuci vašeg veterinara.
English: Reconcile tablets may be given with or without food.
Croatian: Reconcile ablete mogu se davati s hranom ili bez nje.
English: Please inform your veterinary surgeon if your dog is receiving, or has had, any other medicines, even those not prescribed, as the product should not be given at the same time as many other medicines.
Croatian: Obavijestite svog veterinara ako vaš pas prima, ili je primio, bilo koji drugi veterinarsko-medicinski proizvod, čak i ako nije propisan, jer se proizvod ne smije davati istovremeno s brojnim drugim proizvodima.
English: No effect on the reproductive capacity in male and female rats was noted.
Croatian: Nije primijećen učinak na reproduktivni kapacitet ni kod ženskih ni kod muških štakora.
English: At the end of treatment it is not necessary to taper or reduce doses because of the long half-life of this veterinary medicinal product.
Croatian: Na kraju liječenja nije potrebno mijenjati ili smanjivati doze zbog dugog poluraspada ovog veterinarsko-medicinskog proizvoda.
English: If you notice any side effects, even those not already listed in this package leaflet or you think that the medicine has not worked, please inform your veterinary surgeon.
Croatian: Ako zamijetite bilo koje nuspojave, uključujući one koje nisu navedene u ovoj uputi ili mislite da lijek nije bio djelotvoran, molimo da se javite veterinaru.
English: Laboratory studies in rats and rabbits have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effect.
Croatian: Laboratorijskim pokusima na štakorima i zečevima nije dokazan nikakav teratogeni, fetotoksični niti maternotoksični učinak.
English: Clinical improvement with the product is expected within 1 or 2 weeks.
Croatian: Kliničko poboljšanje uz proizvod očekuju se u roku od 1 do 2 tjedna.
English: Clinical improvement with the product is expected within 1 to 2 weeks.
Croatian: Kliničko poboljšanje uz proizvod očekuje se unutar 1 do 2 tjedna.
English: If no improvement is noted within 4 weeks, consult your veterinary surgeon who will need to re-evaluate the dog's treatment.
Croatian: Ako nema poboljšanja unutar 4 tjedna, obratite se svom veterinaru koji će ponovno procijeniti liječenje psa.
English: Do not use this veterinary medicinal product after the expiry date which is stated on the bottle.
Croatian: Ne koristiti ovaj veterinarsko-medicinski proizvod poslije isteka roka valjanosti naznačenog na boci.
English: Fluoxetine is largely metabolised by the liver.
Croatian: Fluoksetin se uglavnom metabolizira u jetri.
English: The tablets are flavoured and most dogs will consume the tablet when offered by the owner.
Croatian: Tablete imaju okus i većina će pasa uzeti tabletu koju im ponudi vlasnik.
English: Clinical studies have shown that a beneficial response has been demonstrated for up to 8 weeks treatment with fluoxetine.
Croatian: Klinička ispitivanja su pokazala kako poželjna reakcija postoji kod liječenja fluoksetinom u trajanju do 8 tjedana.
English: The safety of the veterinary medicinal product has not been established during pregnancy and lactation, thus the use is not recommended during pregnancy and lactation.
Croatian: Neškodljivost veterinarsko-medicinskog proizvoda nije utvrđena za vrijeme graviditeta i laktacije, pa se u tom razdoblju ne preporuča njegova primjena.
English: Medicines should not be disposed of via wastewater or household waste.
Croatian: Proizvodi se ne smiju odlagati u otpadne vode ili u kućni otpad.
English: Adverse reactions as described above, including seizures, are more common after overdose.
Croatian: Neželjene pojave kakve su gore opisane, uključujući napadaje, češće su nakon predoziranja.
English: Accumulation of fluoxetine and norfluoxetine occurred following multiple doses until reaching a steady-state within approximately 10 days.
Croatian: Akumuliranje fluoksetina i norfluoksetina dogodilo se nakon primjene više doza do postizanja stabilnog stanja unutar otprilike 10 dana.
English: Elimination studies in dogs have shown that 29.8% and 44% of the dose were excreted in urine and faeces, respectively by 14 days following dosing.
Croatian: Eliminacijska ispitivanja na psima pokazala su kako se 29,8 % do 44 % doze izlučilo u mokraći i stolici unutar 14 dana od doziranja.
English: Fluoxetine lacks any significant affinity for neurotransmitter receptors, including the muscarinic cholinergic receptor, adrenergic receptors, or histaminergic H1 receptors, and does not have direct effects on the heart.
Croatian: Fluoksetin nema značajnije djelovanje na receptore za neuroprijenos, uključujući muskarinski kolinergijski receptor, adrenergijske receptore ili histaminske H1 receptore i nema izravan učinak na srce.
English: A 6-week washout interval should be observed following discontinuation of therapy with the product prior to the administration of any veterinary medicinal product that may adversely interact with fluoxetine or its metabolite, norfluoxetine.
Croatian: Potrebno je nadzirati razdoblje od 6 tjedana nakon prestanka terapije proizvodom prije primjene bilo kakvog veterinarsko-medicinskog proizvoda koji može na neželjen način reagirati s fluoksetinom ili njegovim metabolitom nurfluoksetinom.
English: Fluoxetine is largely metabolised by the P-450 enzyme system, although the precise isoform in dogs is unknown.
Croatian: Fluoksetin je pod jakim metaboličkim utjecajem sustava enzima P-450, iako je precizna izoforma u pasa nepoznata.