FrancophonIA/ELRC3.0 huggingface dataset:
English: Interactions between efavirenz and protease inhibitors, antiretroviral agents other than protease inhibitors and other non-antiretroviral medicinal products are listed in Table 1 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, and once every 8 or 12 hours as “q8h” or “q12h”).
Croatian: Interakcije između efavirenza i inhibitora proteaze, drugih antiretrovirusnih lijekova osim inhibitora proteaze te drugih lijekova koji nisu antiretrovirusni lijekovi popisane su u Tablici 1 (povećanje je označeno kao "↑", smanjenje kao "↓", bez promjene kao "↔", a jedanput svakih 8 ili 12 sati kao "svakih 8h" ili "svakih 12h").
English: Because of the limited information available, a reliable method of barrier contraception must be used in addition to hormonal contraceptives (see section 4.6).
Croatian: Zbog ograničenosti dostupnih podataka, uz hormonske kontraceptive mora se koristiti pouzdana mehanička metoda kontracepcije (vidjeti dio 4.6).
English: Efavirenz has not been evaluated in children below 3 months of age or who weigh less than 3.5 kg.
Croatian: Efavirenz nije ispitivan u djece mlađe od 3 mjeseca niti u djece čija je tjelesna težina manja od 3,5 kg.
English: Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
Croatian: • prilikom svake izmjene sustava za upravljanje rizicima, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik,
English: Plasma trough concentrations of boceprevir were decreased when administered with efavirenz.
Croatian: Najniže koncentracije boceprevira u plazmi bile su smanjene kada se primjenjivao s efavirenzom.
English: SUSTIVA 600 mg film-coated tablets are also supplied in packs containing 30 x 1 or multipacks of 90 (3 packs of 30 x 1) tablets in aluminium/PVC perforated unit dose blisters.
Croatian: SUSTIVA 600 mg filmom obložene tablete su također dostupne u pakovanjima s 30 x 1 ili u višestrukim pakovanjima od 90 (3 pakovanja po 30 x 1) tableta u aluminij/PVC perforiranim blisterima djeljivim na jedinične doze.
English: AUC: ↓ 51% Cmax: ↓ 21% Dihydroartemisinin: AUC: ↓ 46% Cmax: ↓ 38% Lumefantrine:
Croatian: AUC: ↓ 51% Cmax: ↓ 21% dihidroartemisinin: AUC: ↓ 46% Cmax: ↓ 38% lumefantrin:
English: After administration of the efavirenz-food mixture, an additional small amount (approximately 2 teaspoons) of food must be added to the empty mixing container, stirred to disperse any remaining residue of the medicinal product, and administered to the patient.
Croatian: Nakon uzimanja mješavine efavirenza i hrane u posudu treba staviti dodatnu malu količinu hrane (oko 2 čajne žličice), pomiješati kako bi se pokupili eventualni ostaci lijeka u posudi te dati bolesniku.
English: The clinical significance of these changes in clarithromycin plasma levels is not known.
Croatian: Klinički značaj opaženih promjena koncentracije klaritromicina u plazmi nije poznat.
English: See also ritonavir row above.
Croatian: Vidjeti i navode za ritonavir, gore u tablici.
English: itraconazole.
Croatian: itrakonazol:
English: Packs of 30 x 1 or multipacks of 90 (3 packs of 30 x 1) film-coated tablets in aluminium/PVC perforated unit dose blisters.
Croatian: Pakovanje 30 x 1 ili višestruka pakovanja od 90 (3 pakovanja po 30 x 1) filmom obloženih tableta u aluminij/PVC perforiranim blisterima djeljivima na jedinične doze.
English: LIST OF EXCIPIENTS It contains: lactose monohydrate.
Croatian: 3. POPIS POMOĆNIH TVARI Lijek sadrži: laktozu hidrat.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment.
Croatian: U uvjetima imunološke reaktivacije prijavljeni su i autoimuni poremećaji (kao npr.Gravesova bolest i autoimunog hepatitisa); međutim, prijavljeno vrijeme do pojave je različito i ti se događaji mogu javiti više mjeseci nakon uvođenja liječenja.
English: Eye disorders uncommon vision blurred
Croatian: Poremećaji oka manje često zamagljen vid
English: if you have a heart condition, such as changes in the rhythm or rate of the heart beat, a slow heart beat, or severe heart disease.
Croatian: Posavjetujte se sa svojim liječnikom ili ljekarnikom. ako imate tešku bolest jetre ako imate bolest srca, kao što su promjene ritma ili brzine otkucaja srca, usporene otkucaje srca ili tešku bolest srca.
English: Grapefuit juice should be avoided when taking SUSTIVA.
Croatian: Za vrijeme uzimanja lijeka SUSTIVA treba izbjegavati sok od grejpfruta.
English: AUC: ↑ 21% Cmin: ↑ 17% Cmax: ↑ 15% (CYP3A4 inhibition)
Croatian: AUC: ↑ 21% Cmin: ↑ 17% Cmax: ↑ 15% (inhibicija CYP3A4)
English: Medicines used to treat fungal infections (antifungals): voriconazole.
Croatian: lijekove koji se koriste za liječenje gljivičnih infekcija (antimikotike): vorikonazol.
English: As a result, the amounts of SUSTIVA or other medicines in your blood may be affected.
Croatian: Kao rezultat toga mogu se promijeniti koncentracije lijeka SUSTIVA ili drugih lijekova u krvi.
English: In 35 patients receiving efavirenz 600 mg once daily, steady state Cmax was 12.9 ± 3.7 μM (29%) [mean ± S.D. (% C.V.)], steady state Cmin was 5.6 ± 3.2 μM (57%), and AUC was 184 ± 73 μM·h (40%).
Croatian: U 35 bolesnika koji su primali efavirenz u dozi od 600 mg jedanput na dan u stanju dinamičke ravnoteže Cmax je iznosila 12,9 ± 3,7 μM (29%) [srednja vrijednost ± S.D. (% C.V.)], Cmin 5,6 ± 3,2 μM (57%), a AUC 184 ± 73 μM ·h (40%).
English: The pharmacokinetic parameters for efavirenz at steady state in paediatric patients were predicted by a population pharmacokinetic model and are summarized in Table 4 by weight ranges that correspond to the recommended doses.
Croatian: Farmakokinetički parametri za efavirenz u stanju dinamičke ravnoteže u pedijatrijskih bolesnika predviđeni su farmakokinetičkim modelom populacije i prikazani u tablici 4 prema rasponima tjelesne težine koji odgovaraju preporučenim dozama.
English: Concomitant administration of atovaquone/proguanil with efavirenz should be avoided.
Croatian: Istodobnu primjenu atovakona/progvanilklorida s efavirenzom treba izbjegavati
English: Patients with: - a family history of sudden death or of congenital prolongation of the QTc interval on electrocardiograms, or with any other clinical condition known to prolong the QTc interval.
Croatian: - iznenadnu smrt ili kongenitalno produljenje QTc intervala na elektrokardiogramu u obiteljskoj anamnezi, ili bilo koje drugo kliničko stanje za koje je poznato da uzrokuje produljenje QTc intervala.
English: NAME OF THE MEDICINAL PRODUCT SUSTIVA 50 mg hard capsules SUSTIVA 100 mg hard capsules SUSTIVA 200 mg hard capsules
Croatian: NAZIV LIJEKA SUSTIVA 50 mg tvrde kapsule SUSTIVA 100 mg tvrde kapsule SUSTIVA 200 mg tvrde kapsule
English: In particular, severe depression was more common in those with a history of depression.
Croatian: To se posebno odnosi na tešku depresiju koja se češće javljala u bolesnika s depresijom u anamnezi.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral agents have a higher risk for severe and potentially life-threatening liver problems.
Croatian: Bolesnici s kroničnim hepatitisom B ili C koji se liječe kombinacijom antiretrovirusnih lijekova imaju povećan rizik za razvoj teških i potencijalno po život opasnih jetrenih poremećaja.
English: Atazanavir (pm): AUC: ↔*/** (↓10 to ↑26)
Croatian: atazanavir (popodne): AUC: ↔*/** (↓ 10 do
English: In order to improve the tolerability of nervous system adverse reactions, bedtime dosing is recommended (see section 4.8).
Croatian: Radi lakšeg podnošenja nuspojava na živčani sustav, preporučuje se uzimanje lijeka prije spavanja (vidjeti dio 4.8).
English: If efavirenz is to be used in combination with darunavir/ritonavir, the darunavir/ritonavir 600/100 mg twice daily regimen should be used.
Croatian: Ako se efavirenz primjenjuje u kombinaciji s darunavirom/ritonavirom, treba primijeniti dozu darunavira/ritonavira od 600/100 mg dvaput na dan.
English: AUC: ↓ 13% Cmin: ↓ 31% Cmax: ↓ 15% (CYP3A4 induction) Efavirenz:
Croatian: AUC: ↓ 13% Cmin: ↓ 31% Cmax: ↓ 15% (indukcija CYP3A4) efavirenz:
English: AUC : ↓ 31% (↓ 8 to ↓ 47) Cmin : ↓ 40%
Croatian: AUC: ↓ 31% (↓ 8 do ↓ 47) Cmin: ↓ 40%
English: There have also been post-marketing reports of severe depression, death by suicide, delusions, psychosis-like behaviour and catatonia.
Croatian: Nakon stavljanja lijeka u promet također su prijavljeni slučajevi teške depresije, samoubojstava, deluzija, psihotičnog ponašanja i katatonije.
English: When your SUSTIVA supply starts to run low, get more from your doctor or pharmacist.
Croatian: Kad se Vaša zaliha lijeka SUSTIVA približi kraju, nabavite novo pakiranje od svog liječnika ili ljekarnika.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at increased risk for severe and potentially fatal hepatic adverse reactions.
Croatian: Bolesnici s kroničnim hepatitisom B ili C koji se liječe kombiniranom antiretrovirusnom terapijom izloženi su povećanom riziku od razvoja teških i potencijalno smrtonosnih jetrenih nuspojava.
English: The pharmacokinetic parameters for efavirenz at steady state in paediatric patients were predicted by a population pharmacokinetic model and are summarized in Table 5 by weight ranges that correspond to the recommended doses.
Croatian: Farmakokinetički parametri za efavirenz u stanju dinamičke ravnoteže u pedijatrijskih bolesnika predviđeni su farmakokinetičkim modelom populacije i prikazani u tablici 5 prema t rasponima tjelesne težine koji odgovaraju preporučenim dozama.
English: Biliary hyperplasia was observed in cynomolgus monkeys given efavirenz for ≥ 1 year at a dose resulting in mean AUC values approximately 2-fold greater than those in humans given the recommended dose.
Croatian: Bilijarna hiperplazija opažena je u makaki majmuna koji su efavirenz primali ≥1 godine u dozama kojima je postignut približno dvostruko viši prosječni AUC od onog u ljudi koji su primali preporučenu dozu lijeka.
English: < 50 copies/ml (95% C.I.
Croatian: <50 kopija /ml (95% C.I.
English: There have been occasional postmarketing reports of contraceptive failure with etonogestrel in efavirenzexposed patients.
Croatian: Nakon stavljanja lijeka u promet povremeno je prijavljen izostanak kontraceptivnog učinka etonogestrela u bolesnika koji su uzimali efavirenz.
English: The median time on study therapy was 181 weeks; 16% of patients discontinued before Week 48.
Croatian: Medijan vremena provedenog u ispitivanom liječenju bio je 181 tjedan; 16% bolesnika prekinulo je liječenje prije 48. tjedna.
English: The median time on study therapy was 132 weeks; 27% of patients discontinued before Week 48.
Croatian: Medijan vremena provedenog u ispitivanom liječenju bio je 132 tjedna; 27% bolesnika prekinulo je liječenje prije 48. tjedna.
English: During HIV therapy there may be an increase in weight and in levels of blood lipids and glucose.
Croatian: Tijekom terapije HIV-a moguće je povećanje tjelesne težine i povišenje razina lipida i glukoze u krvi.
English: This loss is due to significant decreases in elbasvir and grazoprevir plasma concentrations caused by CYP3A4 induction.
Croatian: Taj gubitak je posljedica značajnih smanjenja koncentracija elbasvira i grazoprevira u plazmi uzrokovanih indukcijom CYP3A4.
English: Patients with a prior history of psychiatric disorders appear to be at greater risk of these serious psychiatric adverse reactions.
Croatian: Čini se da u bolesnika s psihijatrijskim poremećajima u anamnezi postoji povećan rizik od razvoja ozbiljnih psihijatrijskih nuspojava.
English: ‡These adverse reactions were identified through post-marketing surveillance but not reported as drugrelated events for efavirenz-treated patients in 16 clinical trials.
Croatian: Ove nuspojave zabilježene su tijekom praćenja nakon stavljanja lijeka u promet, ali nisu prijavljene kao nuspojave povezane s lijekom u bolesnika liječenih efavirenzom u 16 kliničkih ispitivanja.
English: No clinically significant effect on efavirenz pharmacokinetics.
Croatian: Nema klinički značajnog učinka na farmakokinetiku efavirenza.
English: What SUSTIVA looks like and contents of the pack SUSTIVA 600 mg film-coated tablets are supplied in bottles of 30 tablets.
Croatian: Kako SUSTIVA izgleda i sadržaj pakovanja SUSTIVA 600 mg filmom obložene tablete dostupne su u bočici s 30 tableta.
English: Concomitant administration of velpatasvir/sofosbuvir/ voxilaprevir with efavirenz is not recommended, as it may decrease concentrations of velpatasvir and voxilaprevir.
Croatian: Istodobna primjena velpatasvira/sofosbuvira/voksilaprev ira s efavirenzom se ne preporučuje, jer može smanjiti koncentracije velpatasvira i voksilaprevira.
English: There have also been post-marketing reports of death by suicide, delusions, psychosis-like behaviour and catatonia.
Croatian: Nakon stavljanja lijeka u promet prijavljeni su i slučajevi samoubojstava sa smrtnim ishodom, deluzija, psihotičnog ponašanja i katatonije.
English: maraviroc the combination tablet containing efavirenz, emtricitabine, and tenofovir should not be taken with SUSTIVA unless recommended by your doctor since it contains efavirenz, the active ingredient of SUSTIVA.
Croatian: maravirok kombinirana tableta koja sadrži efavirenz, emtricitabin i tenofovir ne smije se uzimati s lijekom SUSTIVA, osim ako Vam tako nije preporučio Vaš liječnik, zato što taj lijek sadrži efavirenz, djelatnu tvar lijeka SUSTIVA.
English: < 500 copies/ml
Croatian: < 500 kopija/ml
English: If the coadministration of atazanavir with an NNRTI is required, an increase in the dose of both atazanavir and ritonavir to 400 mg and 200 mg, respectively, in combination with efavirenz could be considered with close clinical monitoring.
Croatian: Ako je potrebno primjenjivati atazanavir istodobno s NNRTI-jem, može se razmotriti povišenje doze atazanavira na 400 mg i ritonavira na 200 mg, u kombinaciji s efavirenzom, pod pomnim kliničkim nadzorom.
English: Medicines used to treat infection with the hepatitis C virus: boceprevir, telaprevir, elbasvir/grazoprevir, simeprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, glecaprevir/pibrentasvir.
Croatian: lijekove koji se koriste za liječenje infekcije virusom hepatitisa C: boceprevir, telaprevir, elbasvir, grazoprevir, simeprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voksilaprevir, glekaprevir/pibrentasvir.
English: Do not use this medicine after the expiry date which is stated on the bottle or blister and on the carton after EXP.
Croatian: Ovaj lijek ne smije se upotrijebiti nakon isteka roka valjanosti navedenog na bočici ili blisteru i kutiji iza EXP/„Rok valjanosti“.
English: 25 to < 32.5
Croatian: 25 do < 32,5
English: Plasma levels of efavirenz can be reduced by concomitant use of St. John's wort due to induction of drug metabolising enzymes and/or transport proteins by St. John's wort.
Croatian: Koncentracija efavirenza u plazmi može se smanjiti zbog istodobne primjene gospine trave zato što gospina trava izaziva indukciju enzima koji metaboliziraju lijek i/ili transportnih proteina.
English: 32.5 to < 40
Croatian: 32,5 do < 40
English: Efavirenz must be discontinued in patients developing severe rash associated with blistering, desquamation, mucosal involvement or fever.
Croatian: Liječenje efavirenzom mora se prekinuti u bolesnika u kojih se razvio jak osip s mjehurićima, deskvamacijom, zahvaćanjem sluznice ili vrućicom.
English: If a patient is already taking St. John's wort, stop St. John's wort, check viral levels and if possible efavirenz levels.
Croatian: Ako bolesnik već uzima gospinu travu, mora prestati s njezinom primjenom te provjeriti koncentraciju virusa i po mogućnosti koncentraciju efavirenza.
English: 5 to < 7.5
Croatian: 5 do < 7,5
English: The most notable unwanted effects reported with SUSTIVA in combination with other anti-HIV medicines are skin rash and nervous system symptoms.
Croatian: Najčešće nuspojave povezane s primjenom lijeka SUSTIVA u kombinaciji s drugim lijekovima za liječenje HIV-a su kožni osip i simptomi živčanog sustava.
English: Viral isolates recovered from PBMCs of patients enrolled in efavirenz clinical studies who showed evidence of treatment failure (viral load rebound) were assessed for susceptibility to NNRTIs.
Croatian: Virusni izolati dobiveni iz mononuklearnih stanica periferne krvi bolesnika u kojih je u kliničkim ispitivanjima izostao odgovor na liječenje efavirenzom (povrat virusnog opterećenja) ispitani su na osjetljivost na NNRTI-je.
English: *compared to 200 mg twice daily alone ** compared to 600 mg once daily alone (competitive inhibition of oxidative metabolism)
Croatian: Cmax: ↔** *u usporedbi s 200 mg dvaput na dan bez efavirenza ** u usporedbi s 600 mg jedanput na dan bez vorikonazola (kompetitivna inhibicija oksidativnog metabolizma)
English: The mean baseline CD4 cell count was 341 cells/mm3 and the mean baseline HIV-RNA level was 60,250 copies/ml.
Croatian: Srednja vrijednost početnog broja CD4 stanica iznosila je 341 stanica/mm3, a srednja početna vrijednost HIV-RNK bila je 60 250 kopija/ml.
English: uncommon agitation, amnesia, ataxia, coordination abnormal, convulsions, thinking abnormal,* tremor†
Croatian: manje često agitacija, amnezija, ataksija, poremećaj koordinacije, konvulzije, poremećeno razmišljanje*, tremor†
English: 12 Add another small amount (approximately 2 teaspoons) of the food to the empty mixing container (illustration a).
Croatian: 12 Dodajte malu količinu (otprilike 2 čajne žličice) hrane u praznu posudu za miješanje
English: SUSTIVA is not recommeded for children under the age of 3 months or weighing less than 3.5 kg because it has not been adequately studied in these patients.
Croatian: SUSTIVA se ne preporučuje za djecu mlađu od 3 mjeseca ili djecu tjelesne težine manje od 3,5 kg jer u tih bolesnika nije ispitan na odgovarajući način.
English: Efavirenz should not be used during pregnancy, unless the patient's clinical condition requires such treatment.
Croatian: Pogledajte nastavak teksta i dio 5.3. Efavirenz se ne smije primjenjivati tijekom trudnoće, osim ako kliničko stanje bolesnice ne zahtijeva takvo liječenje.
English: < 400 copies/ml
Croatian: < 400 kopija/ml
English: The bioavailability of a single 600 mg dose of efavirenz hard capsules in uninfected volunteers was increased 22% and 17%, respectively, when given with a meal of high fat or normal composition, relative to the bioavailability of a 600 mg dose given under fasted conditions (see section 4.4).
Croatian: Bioraspoloživost jednokratne doze od 600 mg efavirenz tvrdih kapsula u nezaraženih dobrovoljaca porasla je 22% kada je lijek primjenjen s punomasnim obrokom, a 17% kada je primijenjen s normalnim obrokom u usporedbi s bioraspoloživošću doze od 600 mg primijenjene natašte (vidjeti dio 4.4).
English: Anencephaly and unilateral anophthalmia with secondary enlargement of the tongue were observed in one foetus, microophthalmia was observed in another foetus, and cleft palate was observed in a third foetus.
Croatian: U jednog ploda opažene su anencefalija i unilateralna anoftalmija sa sekundarnim povećanjem jezika, u drugog je zabilježena mikrooftalmija, a u trećega rascjep nepca.
English: if you have a history of convulsions (fits or seizures) or if you are being treated with anticonvulsant therapy such as carbamazepine, phenobarbital and phenytoin.
Croatian: ako ste nekada imali konvulzije (napadaje) ili se liječite antikonvulzivnim lijekovima kao što su karbamazepin, fenobarbital i fenitoin.
English: ANTICOAGULANTS Warfarin/Efavirenz Acenocoumarol/Efavirenz
Croatian: ANTIKOAGULANSI varfarin/efavirenz acenokumarol/efavirenz
English: Reproductive system and breast disorders uncommon gynaecomastia
Croatian: Poremećaji reproduktivnog sustava i dojki manje često ginekomastija
English: Other special populations
Croatian: Ostale posebne populacije bolesnika
English: SUSTIVA is indicated in antiviral combination treatment of human immunodeficiency virus-1 (HIV1) infected adults, adolescents and children 3 months of age and older and weighing at least 3.5 kg.
Croatian: SUSTIVA je indicirana u kombiniranom antivirusnom liječenju odraslih, adolescenata i djece u dobi od 3 mjeseca i starijih te tjelesne težine od najmanje 3,5 kg, zaraženih virusom humane imunodeficijencije tipa 1 (HIV-1).
English: PHARMACEUTICAL FORM Film-coated tablet
Croatian: Filmom obložena tableta
English: SUSTIVA is not recommeded for children under the age of 3 months or weighing less than 3.5 kg because it has not been adequately studied in these patients
Croatian: SUSTIVA se ne preporučuje za djecu mlađu od 3 mjeseca ili djecu tjelesne težine manje od 3,5 kg jer u tih bolesnika nije ispitan na odgovarajući način
English: No dose adjustment is necessary for any of these medicinal products.
Croatian: Nije potrebno prilagođavati dozu ni jednog od ovih lijekova.
English: Concomitant use of St. John's wort is contraindicated (see section 4.3).
Croatian: Istodobna primjena s gospinom travom je kontraindicirana (vidjeti dio 4.3).
English: Administration of activated charcoal may be used to aid removal of unabsorbed efavirenz.
Croatian: Kako bi se olakšalo uklanjanje neapsorbiranog efavirenza može se primijeniti aktivni ugljen.
English: Table 5: Predicted steady-state pharmacokinetics of efavirenz (capsules/capsule sprinkles) in HIV-infected paediatric patients
Croatian: Tablica 5: Predviđena farmakokinetika u stanju dinamičke ravnoteže efavirenza (kapsule/posipanje sadržaja kapsule) u pedijatrijskih bolesnika zaraženih HIV-om
English: The nervous system symptoms tend to occur when treatment is first started, but generally decrease in the first few weeks.
Croatian: Simptomi živčanog sustava obično se pojavljuju na početku liječenja i u pravilu se smanjuju u prvih nekoliko tjedana.
English: MSD Α.Φ.Β.Ε.Ε Τηλ: + 30-210 98 97 300 dpoc_greece@merck.com
Croatian: MSD Α.Φ.Β.Ε.Ε Τηλ: + 30 210 98 97 300 cora.greece.gragcm@merck.com
English: 3.5 to < 5
Croatian: 3,5 do < 5
English: Liver enzymes: elevations of AST and ALT to greater than five times the upper limit of the normal range (ULN) were seen in 3% of 1,008 patients treated with 600 mg of efavirenz (5-8% after longterm treatment in study 006).
Croatian: Jetreni enzimi: povišene vrijednosti AST-a i ALT-a više od pet puta iznad gornje granice normale (GGN) opažene su u 3% od 1008 bolesnika liječenih efavirenzom u dozi od 600 mg (5-8% nakon dugotrajnog liječenja u ispitivanju 006).
English: The potential for cross resistance between efavirenz and PIs is low because of the different enzyme targets involved.
Croatian: Vrlo je mala vjerojatnost za križnu rezistenciju između efavirenza i inhibitora proteaze jer se vežu na različite ciljne enzime.
English: SUSTIVA contains lactose in each 600-mg daily dose.
Croatian: SUSTIVA sadrži laktozu u jednoj dnevnoj dozi od 600 mg.
English: AUC: ↓71% (↓67 to ↓74) Cmax: ↓51% (↓46 to ↓56) Cmin: ↓91% (↓88 to ↓92) Efavirenz:
Croatian: AUC: ↓ 71% (↓ 67 do ↓ 74) Cmax: ↓ 51% (↓ 46 do ↓ 56) Cmin: ↓ 91% (↓ 88 do ↓ 92) efavirenz:
English: cells/mm3 (S.E.M.d)
Croatian: stanica/mm3 (S.E.M.
English: Prophylaxis with appropriate antihistamines prior to initiating therapy with efavirenz in children may be considered.
Croatian: Može se razmotriti profilaksa odgovarajućim antihistaminicima prije početka liječenja djece efavirenzom.
English: GENERAL CLASSIFICATION FOR SUPPLY Medicinal product subject to medical prescription.
Croatian: 14. NAČIN PROPISIVANJA LIJEKA Lijek se izdaje na recept.
English: The median time on study therapy was 118 weeks; 25% of patients discontinued before Week 48.
Croatian: Medijan vremena provedenog u ispitivanom liječenju bio je 118 tjedana; 25% bolesnika prekinulo je liječenje prije 48. tjedna.
English: < 50 copies/ml
Croatian: < 50 kopija/ml