FrancophonIA/ELRC3.0 huggingface dataset:
English: Similar effects occurred in patients receiving placebo.
Slovenian: Podobni učinki so se pojavili pri bolnikih, ki so prejemali placebo.
English: Mulpleo received a marketing authorisation valid throughout the EU on 18 February 2019.
Slovenian: Za zdravilo Mulpleo je bilo 18. februarja 2019 izdano dovoljenje za promet, veljavno po vsej EU.
English: What measures are being taken to ensure the safe and effective use of Mulpleo?
Slovenian: Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Mulpleo?
English: The European Medicines Agency decided that Mulpleo's benefits are greater than its risks and it can be authorised for use in the EU.
Slovenian: Evropska agencija za zdravila je zaključila, da so koristi zdravila Mulpleo večje od z njim povezanih tveganj in da se lahko odobri za uporabo v EU.
English: Other information about Mulpleo
Slovenian: Druge informacije o zdravilu Mulpleo
English: Treatment with Mulpleo should start at least 8 days before the procedure and the recommended dose is 1 tablet daily for 7 days.
Slovenian: Zdravljenje z zdravilom Mulpleo je treba začeti najmanj osem dni pred posegom, priporočeni odmerek pa je ena tableta na dan, sedem dni.
English: What benefits of Mulpleo have been shown in studies?
Slovenian: Kakšne koristi zdravila Mulpleo so se pokazale v študijah?
English: 1 Previously known as Lusutrombopag Shionogi.
Slovenian: 1 Prej znano pod imenom Lusutrombopag Shionogi.
English: As for all medicines, data on the use of Mulpleo are continuously monitored.
Slovenian: Tako kot za vsako zdravilo se tudi podatki o uporabi zdravila Mulpleo stalno spremljajo.
English: What is Mulpleo and what is it used for?
Slovenian: Kaj je zdravilo Mulpleo in za kaj se uporablja?
English: Why is Mulpleo authorised in the EU?
Slovenian: Zakaj je bilo zdravilo Mulpleo odobreno v EU?
English: Mulpleo is available as 3 mg tablets.
Slovenian: Zdravilo Mulpleo je na voljo v obliki 3-miligramskih tablet.
English: An overview of Mulpleo and why it is authorised in the EU
Slovenian: Pregled zdravila Mulpleo in zakaj je odobreno v EU
English: What are the risks associated with Mulpleo?
Slovenian: Kakšna tveganja so povezana z zdravilom Mulpleo?
English: Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Mulpleo have been included in the summary of product characteristics and the package leaflet.
Slovenian: Priporočila in previdnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Mulpleo upoštevati zdravstveni delavci in bolniki, so vključeni v povzetek glavnih značilnosti zdravila in navodilo za uporabo.
English: Side effects reported with Mulpleo are carefully evaluated and any necessary action taken to protect patients.
Slovenian: Neželeni učinki, o katerih so poročali pri zdravilu Mulpleo, se skrbno ovrednotijo in po potrebi se sprejmejo ukrepi za zaščito bolnikov.
English: Unwanted effects that occurred in studies are thought to result from patients' medical condition and the nature of the invasive procedure for which Mulpleo was used.
Slovenian: Neželeni učinki, ki so se pojavili v študijah, naj bi bili posledica zdravstvenega stanja bolnikov in narave invazivnega posega, pri katerem je bilo zdravilo Mulpleo uporabljeno.
English: Mulpleo is a medicine used to prevent excessive bleeding in adults with thrombocytopenia due to longstanding liver disease.
Slovenian: Mulpleo je zdravilo, ki se uporablja za preprečevanje čezmerne krvavitve pri odraslih s trombocitopenijo zaradi dolgotrajne bolezni jeter.
English: For more information about using Mulpleo, see the package leaflet or contact your doctor or pharmacist.
Slovenian: Za več informacij glede uporabe zdravila Mulpleo glejte navodilo za uporabo ali se posvetujte z zdravnikom ali farmacevtom.
English: The second study involving 215 adults found that 65% of patients who took Mulpleo did not require platelet transfusion before their procedure, compared with 29% of patients who received placebo.
Slovenian: V drugi študiji, v katero je bilo vključenih 215 odraslih, so ugotovili, da 65 % bolnikov, ki so jemali zdravilo Mulpleo, pred posegom ni potrebovalo transfuzije trombocitov, v primerjavi z 29 % bolnikov, ki so prejemali placebo.
English: Unwanted effects that occurred in studies involving patients taking Mulpleo were headache, nausea (feeling sick), portal vein thrombosis (a blockage in the blood vessel that carries blood from the intestines to the liver) and rash.
Slovenian: Neželeni učinki, ki so se pojavili v študijah, v katere so bili vključeni bolniki, ki so prejemali zdravilo Mulpleo, so bili glavobol, navzeja (siljenje na bruhanje), tromboza portalne vene (zapora krvne žile, ki prenaša kri iz črevesja v jetra) in izpuščaj.
English: The active substance in Mulpleo, lusutrombopag, attaches to the same receptors as thrombopoietin, helping to increase the platelet count.
Slovenian: Učinkovina v zdravilu Mulpleo, lusutrombopag, se veže na iste receptorje kot trombopoetin in pomaga povečati število trombocitov.
English: Mulpleo1 (lusutrombopag)
Slovenian: (lusutrombopag)
English: Studies have found that Mulpleo increases platelet count, thereby lowering the risk of excessive bleeding during or after an invasive procedure and reducing the need for transfusing platelets.
Slovenian: V študijah se je izkazalo, da zdravilo Mulpleo poveča število trombocitov, s čimer zmanjša tveganje za čezmerno krvavitev med invazivnim posegom ali po njem ter potrebo po transfuziji trombocitov.
English: The first study, involving 96 adults, found that 79% of patients who took Mulpleo did not require a transfusion of platelets before their procedure, compared with 13% of patients who received placebo (a dummy treatment).
Slovenian: V prvi študiji, v katero je bilo vključenih 96 odraslih, so ugotovili, da 79 % bolnikov, ki so jemali zdravilo Mulpleo, pred posegom ni potrebovalo transfuzije trombocitov, v primerjavi s 13 % bolnikov, ki so prejemali placebo (zdravilo brez učinkovine).
English: In two main studies involving adults with low levels of platelets due to long-standing liver disease, Mulpleo increased platelet count before an invasive procedure and reduced the need for transfusions.
Slovenian: V dveh glavnih študijah, v kateri so bili vključeni odrasli z majhnim številom trombocitov zaradi dolgotrajne bolezni jeter, je zdravilo Mulpleo povečalo število trombocitov pred invazivnim posegom in zmanjšalo potrebo po transfuzijah.
English: Mulpleo contains the active substance lusutrombopag.
Slovenian: Zdravilo Mulpleo vsebuje učinkovino lusutrombopag.
English: How is Mulpleo used?
Slovenian: Kako se zdravilo Mulpleo uporablja?
English: For more information on the side effects and restrictions of Mulpleo, see the package leaflet.
Slovenian: Za več informacij o neželenih učinkih in omejitvah pri uporabi zdravila Mulpleo glejte navodilo za uporabo.
English: How does Mulpleo work?
Slovenian: Kako zdravilo Mulpleo deluje?
English: This generally takes 30 minutes.
Slovenian: To na splošno traja 30 minut.
English: You do not need to do anything about it.
Slovenian: Glede tega vam ni treba narediti ničesar.
English: Date of first authorisation: 8 January 2018
Slovenian: Datum prve odobritve: 8. januar 2018
English: Individual day and night time scores were similar.
Slovenian: Posamezne ocene podnevi in ponoči so bile podobne.
English: Long-term safety
Slovenian: Dolgoročna varnost
English: • through clothing
Slovenian: • skozi oblačila.
English: Important!
Slovenian: Pomembno!
English: Let it air dry.
Slovenian: Pustite, da se na zraku posuši.
English: Gender, Race
Slovenian: Spol, rasa
English: Not known (the frequency cannot be determined from the available data):
Slovenian: Neznana pogostnost (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti):
English: This creates a firmer surface.
Slovenian: Tako boste ustvarili bolj čvrsto površino.
English: Elderly patients (≥65 years old)
Slovenian: Starejši bolniki (stari ≥ 65 let)
English: Such reactions may happen within hours or days after the injection.
Slovenian: Takšne reakcije se lahko pojavijo v nekaj urah ali dneh potem, ko ste dobili injekcijo.
English: Total duration of treatment: 104 - 112 weeks
Slovenian: Celotno trajanje zdravljenja: 104-112 tednov.
English: It is important that you talk to your doctor about how to recognise early symptoms of serious allergic reactions and how to manage these reactions if they occur.
Slovenian: Pomembno je, da se z zdravnikom pogovorite o tem, kako prepoznati zgodnje simptome resnih alergijskih reakcij in kako te reakcije obvladati, če se pojavijo.
English: Wash your hands well with soap and water.
Slovenian: Roke si dobro umijte z milom in vodo.
English: Children and adolescents The safety and benefits of this medicine are not known in children below the age of 18.
Slovenian: Otroci in mladostniki Varnost in koristi tega zdravila niso znane pri otrocih, mlajših od 18 let.
English: • if you have a parasitic infection or if you live in an area where parasitic infections are common or you are travelling to such a region.
Slovenian: • če imate kakšno okužbo s paraziti, če živite na območju, kjer so parazitske okužbe pogoste, ali potujete na takšno območje.
English: It may contain small white particles.
Slovenian: Vsebuje lahko majhne bele delce.
English: Results shown based on last available data for each variable.
Slovenian: Prikazani so rezultati na podlagi zadnjega razpoložljivega podatka za vsako posamezno spremenljivko.
English: There may be new information.
Slovenian: Vključene so namreč lahko kakšne nove informacije.
English: These reactions may occur within hours of administration, but in some instances have a delayed onset (i.e. days).
Slovenian: Te reakcije se lahko pojavijo v nekaj urah po uporabi, a v nekaterih primerih se pojavijo pozno (tj. v nekaj dneh).
English: No dedicated animal studies have been conducted.
Slovenian: Namenskih študij na živalih niso izvedli.
English: n= number of patients with data at timepoint.
Slovenian: n=število bolnikov, ki so na časovni točki imeli podatke.
English: Number of patients (n) varies slightly due to the number of patients for whom data were available for each variable.
Slovenian: Število bolnikov (n) se rahlo razlikuje zaradi števila bolnikov, za katere so bili podatki na voljo za vsako posamezno spremenljivko.
English: The green needle guard is now exposed.
Slovenian: Zeleni ščitnik igle je zdaj izpostavljen.
English: This should be done gradually, under the direct supervision of your doctor.
Slovenian: To je treba opraviti postopoma, pod neposrednim nadzorstvom zdravnika.
English: If the green plunger does not fill the viewing window, you may not have received the full dose.
Slovenian: Če zeleni bat ne napolni okenca za ogled, morda niste prejeli celotnega odmerka.
English: You will hear a second ‘click'.
Slovenian: Slišali boste drugi "klik".
English: However, no data are available in patients over 75 years of age.
Slovenian: Toda za bolnike, starejše od 75 let, podatkov ni.
English: Median percent reduction
Slovenian: Mediani odstotek zmanjšanja
English: Most antibodies were neutralising and persistent.
Slovenian: Večina protiteles je bila nevtralizirajočih in dolgotrajnih.
English: Hold down firmly for 15 seconds.
Slovenian: Držite močno pritisnjeno 15 sekund.
English: For each injection, choose a different site that is at least 3 cm away from where you last injected.
Slovenian: Za vsako injiciranje izberite drugo mesto, ki je vsaj 3 cm proč od mesta, kamor ste zdravilo injicirali zadnjič.
English: Its administration to pregnant women should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus.
Slovenian: Njegova uporaba pri nosečnicah pride v poštev le, če je pričakovana korist za mater večja od vsakega možnega tveganja za plod.
English: It may contain particles.
Slovenian: Lahko vsebuje delce.
English: Open the carton.
Slovenian: Odprite škatlo.
English: Risk to the breast-fed child cannot be excluded.
Slovenian: Tveganja za dojene otroke ni mogoče izključiti.
English: For examples of the associated manifestations reported and a description of the time to onset, see section 4.4.
Slovenian: Za primere opisanih povezanih manifestacij in opis časa do njihovega pojava glejte poglavje 4.4.
English: Currently available data in children 12 to less than 18 years old are described in sections 4.8, 5.1 and 5.2 but no recommendation on a posology can be made.
Slovenian: Trenutno razpoložljivi podatki pri otrocih, starih od 12 do 18 let, so opisani v poglavjih 4.8, 5.1 in 5.2, vendar priporočil o odmerjanju ni mogoče dati.
English: Difference
Slovenian: Razlika
English: You will hear a click.
Slovenian: Slišali boste "klik".
English: There are no fertility data in humans.
Slovenian: Podatkov o plodnosti pri človeku ni.
English: The second click tells you the injection has finished.
Slovenian: Drugi klik vam pove, da je injiciranje končano.
English: Go straight on to the next steps, without delay.
Slovenian: Brez odlašanja nadaljujte z naslednjimi koraki.
English: Other medicines for asthma
Slovenian: Druga zdravila za astmo
English: Do not inject:
Slovenian: Ne injicirajte:
English: The results summarised below are those for the recommended dosing regimen.
Slovenian: Spodaj povzeti rezultati se nanašajo na priporočeno shemo odmerjanja.
English: Do not use this medicine after the expiry date which is stated on the label.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki.
English: • the security seal on the carton has been broken
Slovenian: • če je varnostni pečat na škatli pretrgan,
English: Press down firmly.
Slovenian: Močno pritisnite navzdol.
English: This medicine may weaken your ability to fight certain types of parasitic infections,
Slovenian: To zdravilo namreč lahko oslabi vašo zmožnost za premagovanje določenih vrst okužb s paraziti.
English: This is to make sure you inject all of the medication.
Slovenian: Tako se boste prepričali, da ste injicirali vse zdravilo.
English: Check the viewing window to make sure all the liquid has been injected.
Slovenian: Preverite okence za ogled in se tako prepričajte, da je bila injicirana vsa tekočina.
English: Nijmegen, 6545CG Netherlands
Slovenian: Nijmegen, 6545CG Nizozemska
English: • If you are allergic to benralizumab or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični na benralizumab ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: The IL-5 receptor is specifically expressed on the surface of eosinophils and basophils.
Slovenian: Receptor IL-5 je specifično izražen na površini eozinofilcev in bazofilcev.
English: • fever (high temperature)
Slovenian: • zvišana telesna temperatura (vročina)
English: • into scars or damaged skin
Slovenian: • v brazgotine ali poškodovano kožo,
English: This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
Slovenian: Te informacije niso nadomestilo za pogovor z zdravnikom o vaši bolezni in vašem zdravljenju.
English: Following subcutaneous administration, the elimination half-life was approximately 15.5 days.
Slovenian: Po subkutani uporabi je bil razpolovni čas izločanja približno 15,5 dni.
English: Keep pushing until it is down as far as it will go.
Slovenian: Potiskajte navzdol, dokler gre.
English: Patients were permitted to enter a second extension trial after a minimum of 8 weeks in Trial 4 without completing the 56-week extension period.
Slovenian: Bolniki so smeli vstopiti v drugo podaljšano preskušanje po vsaj 8 tednih v preskušanju 4, brez dokončanja 56-tedenskega obdobja podaljšanja.
English: The most commonly reported adverse reactions during treatment are headache (8%) and pharyngitis (3%).
Slovenian: Najpogosteje opisana neželena učinka med zdravljenjem sta glavobol (8 %) in faringitis (3 %).
English: Do not try to inject yourself in the arm.
Slovenian: Ne poskušajte si zdravila sami injicirati v roko.
English: Serious allergic reactions
Slovenian: Resne alergijske reakcije
English: Make sure you can see the viewing window.
Slovenian: Poskrbite, da boste videli okence za ogled.
English: A ‘click' tells you the injection has started.
Slovenian: "Klik" vam pove, da se je injiciranje začelo.
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from using Fasenra taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Slovenian: Odločiti se je treba bodisi za prenehanje dojenja bodisi za prekinitev/prenehanje uporabe zdravila Fasenra, upoštevaje koristi dojenja za otroka in koristi zdravljenja za žensko.
English: The frequency of adverse reactions is defined using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); and not known (cannot be estimated from available data).
Slovenian: Pogostnost neželenih učinkov je opredeljena upoštevaje naslednji dogovor: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
English: If an injection is missed on the planned date, dosing should resume as soon as possible on the indicated regimen; a double dose must not be administered.
Slovenian: Če je injekcija na načrtovani datum izpuščena, je treba z uporabo zdravila nadaljevati čim prej po predvideni shemi; ne sme se uporabiti dvojnega odmerka.
English: Complete the following steps right away after removing the cap.
Slovenian: Naslednje korake opravite takoj potem, ko odstranite pokrovček.
English: The frequency, type and severity of adverse reactions in the adolescent population were observed to be similar to those seen in adults.
Slovenian: Opažena pogostnost, vrsta in resnost neželenih učinkov so bile v populaciji mladostnikov podobne kot pri odraslih.
English: Follow your healthcare provider's instructions on how to inject.
Slovenian: Upoštevajte zdravnikova navodila o tem, kako injicirati.
English: • into the 5 cm area around your belly-button
Slovenian: • v predel 5 cm okrog popka,
English: b. Integrated analysis of Trial 1 and 2 baseline includes adults and adolescents.
Slovenian: b. Združena analiza izhodišča v preskušanjih 1 in 2 vključuje odrasle in mladostnike.
English: Common (these may affect up to 1 in 10 people)
Slovenian: Pogosti (pojavijo se lahko pri največ 1 od 10 bolnikov)
English: If your asthma symptoms get worse while receiving injections of Fasenra, call your doctor.
Slovenian: Če se vam simptomi astme med prejemanjem injekcij zdravila Fasenra poslabšajo, pokličite zdravnika.
English: No conclusion can be drawn regarding asthma efficacy in the paediatric population.
Slovenian: O učinkovitosti pri astmi v pediatrični populaciji ni mogoče sklepati.
English: You may see a drop of liquid at the end of the needle.
Slovenian: Na koncu igle se lahko pojavi kapljica tekočine.
English: • it has been frozen
Slovenian: • če je bilo zdravilo zamrznjeno,
English: If overdose occurs, the patient should be treated supportively with appropriate monitoring as necessary.
Slovenian: V primeru prevelikega odmerjanja je treba bolnika podporno zdraviti in mu zagotoviti ustrezno spremljanje, kot je potrebno.
English: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.
Slovenian: Če ste noseči, menite, da bi lahko bili noseči, ali načrtujete zanositev, se posvetujte z zdravnikom, preden prejmete to zdravilo.
English: Efficacy and safety were consistent with the predecessor trials.
Slovenian: Učinkovitost in varnost sta se skladali z učinkovitostjo in varnostjo, ugotovljenima v predhodnih preskušanjih.
English: Animal toxicology and/or pharmacology
Slovenian: Toksikologija in/ali farmakologija pri živalih
English: Table 5 summarizes the study results for Trial 3.
Slovenian: Preglednica 5 povzema rezultate Preskušanja 3.
English: Subgroup analyses by prior exacerbation history
Slovenian: Analize podskupin glede na predhodno anamnezo poslabšanj
English: • if you have any symptoms of an allergic reaction (see section 4).
Slovenian: • če se vam pojavi kakršen koli simptom alergijske reakcije (glejte poglavje 4).
English: If needed, cover the injection site with a small bandage.
Slovenian: Če je treba, mesto injiciranja pokrijte z majhnim povojem.
English: d. EOT for Trial 4 was Week 48 (the last timepoint for adults and adolescent data).
Slovenian: d. Konec zdravljenja v preskušanju 4 je bil 48. teden (zadnja časovna točka za podatke odraslih in mladostnikov).
English: It is there to prevent you from touching the needle.
Slovenian: Njegova naloga je, da prepreči, da bi se dotaknili igle.
English: Allergic reactions have occurred in patients receiving this medicine.
Slovenian: Bolnikom, ki so prejemali to zdravilo, so se pojavile alergijske reakcije.
English: You could cause the injection to happen too soon or damage the needle.
Slovenian: S tem namreč lahko povzročite, da se injiciranje začne prezgodaj, ali poškodujete iglo.
English: For example, do not warm it in a microwave or hot water, or put it near other heat sources.
Slovenian: Tako ga na primer ne smete segrevati v mikrovalovni pečici ali vroči vodi, ali ga dati poleg drugih virov toplote.
English: Rate a.
Slovenian: Delež a.
English: The liquid should be clear and colourless to yellow.
Slovenian: Tekočina mora biti bistra in brezbarvna do rumena.
English: Check the expiry date (EXP).
Slovenian: Preverite datum izteka roka uporabnosti (EXP).
English: The overall adverse event profile was similar to the asthma trials described above.
Slovenian: Na splošno je bil profil neželenih učinkov podoben kot v zgoraj opisanih preskušanjih pri astmi.
English: It is preferable to avoid the use of Fasenra during pregnancy.
Slovenian: Uporabi zdravila Fasenra se je med nosečnostjo bolje izogniti.
English: BATCH NUMBER<, DONATION AND PRODUCT CODES>
Slovenian: ŠTEVILKA SERIJE<, ENOTNE OZNAKE DAROVANJA IN IZDELKOV>
English: No data are available for children aged 6 to 11 years old.
Slovenian: Za otroke, stare od 6 do 11 let, podatkov ni na voljo.
English: Paediatric population The safety and efficacy of Fasenra in children aged 6 to 18 years have not been established.
Slovenian: Pediatrična populacija Varnost in učinkovitost zdravila Fasenra pri otrocih, starih od 6 do 18 let, nista bili dokazani.
English: Do not try to touch the needle or push on the needle guard with your finger.
Slovenian: Ne poskušajte se dotakniti igle ali pritiskati na ščitnik igle s prstom.
English: MedImmune UK Ltd 6 Renaissance Way Liverpool, L24 9JW United Kingdom
Slovenian: MedImmune UK Ltd 6 Renaissance Way Liverpool, L24 9JW Velika Britanija
English: Inject Fasenra by following the steps in figures a, b, c and d.
Slovenian: Injicirajte zdravilo Fasenra tako, da sledite korakom na slikah a, b, c in d.
English: Overall, in patients who were anti-drug antibody positive in the predecessor trials, titres remained stable or declined in the second year of treatment.
Slovenian: Na splošno so pri bolnikih, pozitivnih za protitelesa proti zdravilu v predhodnih preskušanjih, med drugim letom zdravljenja titri ostali stabilni ali so se zmanjšali.
English: If you are taking medicines called ‘oral corticosteroids', using Fasenra may also allow you to reduce the daily dose or stop the oral corticosteroids you need to control your asthma.
Slovenian: Če jemljete zdravila, imenovana "peroralni kortikosteroidi", vam lahko zdravilo Fasenra omogoči tudi zmanjšanje njihovega dnevnega odmerka ali prenehanje uporabe peroralnih kortikosteroidov, ki jih potrebujete za obvladovanje astme.
English: Exacerbations over an extended treatment period
Slovenian: Poslabšanja med podaljšanim obdobjem zdravljenja
English: Disposal guidelines
Slovenian: Smernice za odstranjevanje
English: Asthma symptom scale: total score from 0 (least) to 6 (most); day and night time asthma symptom scores from 0 (least) to 3 (most) symptoms.
Slovenian: Lestvica simptomov astme: celotna ocena od 0 (najmanj) do 6 (največ); ocena simptomov astme podnevi in ponoči od 0 (najmanj) do 3 (največ) simptomov.