FrancophonIA/ELRC3.0 huggingface dataset:
English: Alopecia Pruritus Urticaria Skin disorder
Danish: Alopeci Pruritus Urticaria Hudsygdom
English: Biotec Services International Ltd. Biotec House, Central Park, Western Avenue Bridgend Industrial Estate Bridgend, CF31 3RT, UK And
Danish: Biotec House, Central Park, Western Avenue Bridgend Industrial Estate Bridgend, CF31 3RT, Storbritannien og
English: Secondary efficacy
Danish: Sekondært effektmål
English: Diffuse large B cell non-Hodgkin's lymphoma
Danish: Diffust storcellet B-celle non-Hodgkin-lymfom
English: This medicinal product contains 263.2 mg sodium per 50 mL vial, equivalent to 13.2% of the WHO recommended maximum daily intake of 2 g sodium for an adult.For the full list of excipients, see section 6.1.
Danish: Dette lægemiddel indeholder 263,2 mg natrium pr. 50 mL hætteglas, svarende til 13,2% af den WHO anbefalede maximale daglige indtagelse af 2 g natrium for en voksen.
English: Neutropenic events, including severe late onset and persistent neutropenia, have been rarely reported in the post-marketing setting, some of which were associated with fatal infections.
Danish: Efter markedsføring har neutropeniske hændelser, herunder svær sent indsættende og vedvarende neutropeni, sjældent været rapporteret.
English: • eating disorders, not eating enough, leading to weight loss
Danish: • spiseforstyrrelser, for lille fødeindtagelse, der medfører vægttab
English: In CLL, the overall incidence of grade 3 or 4 cardiac disorders was low both in the first-line study (4% R-FC, 3% FC) and in the relapsed/refractory study (4% R-FC, 4% FC).
Danish: Ved CLL var incidensen af hjertesygdomme af grad 3 eller 4 lav både i 1. linjestudiet (4 % R-FC, 3 % FC) og i relaps/refraktær studiet (4 % R-FC, 4 % FC).
English: This will be administered 1 year and 18 months after the initial treatment and then every 6 months as needed or your doctor may change this, depending on how you respond to the medicine.
Danish: Vedligeholdelsesbehandling vil gives 1 år og 18 måneder efter behandlingens start og herefter hver 6. måned efter behov.
English: Very rare cases of progressive multifocal leukoencephalopathy (PML) have been reported during post-marketing use of rituximab in NHL and CLL (see section 4.8).
Danish: Der er i meget sjældne tilfælde blevet rapporteret om tilfælde af progressiv multifokal leukoencefalopati (PML) efter markedsføring af rituximab hos patienter med NHL og CLL (se pkt.
English: The mean Cmax (N=15) was 408 µg/mL (range, 97 - 764 µg/mL) after the fifth 500 mg/ m2 infusion and the mean terminal half-life was 32 days (range, 14 - 62 days).
Danish: Efter den femte 500 mg/m2 infusion var den gennemsnitlige Cmax (N = 15) 408 µg/ml (spændvidde 97-764 µg/ml), og den gennemsnitlige terminale halveringstid var 32 dage (spændvidde 14-62 dage).
English: You must also do this for 12 months after your last treatment with Ritemvia.
Danish: I skal fortsætte med sikker prævention i 12 måneder efter din sidste behandling med Ritemvia.
English: This medicinal product contains 52.6 mg sodium per 10 mL vial, equivalent to 2.6% of the WHO recommended maximum daily intake of 2 g sodium for an adult.For the full list of excipients, see section 6.1.
Danish: Dette lægemiddel indeholder 52,6 mg natrium pr. 10 mL hætteglas, svarende til 2,6% af den WHO anbefalede maximale daglige indtagelse af 2 g natrium for en voksen.
English: Influenza-like illness Oedema peripheral
Danish: Influenzalignende symptomer Perifert ødem
English: tachycardia, +cardiac disorder tachycardia, +ventricular tachycardia, +angina, +myocardial ischaemia, bradycardia
Danish: +venstre ventrikulært svigt, +supraventrikulær takykardi, +ventrikulær takykardi, +angina, +myokardieiskæmi, bradykardi,
English: cell return, with counts > 10 cells/μL by month 12, increasing to 87% of patients by month 18.
Danish: Størstedelen af patienterne (81 %) viste tegn på B-celleregenerering med > 10 celler/mikroliter ved måned 12; dette steg til 87 % af patienterne ved måned 18.
English: Peripheral blood B cell counts begin to increase from week 24 and evidence for repopulation is observed in the majority of patients by week 40, whether rituximab was administered as monotherapy or in combination with methotrexate.
Danish: Tegn på gendannelse af B-celler blev observeret hos størstedelen af patienterne ved uge 40, uanset om rituximab blev anvendt som monoterapi eller i kombination med methotrexat.
English: They were characterised by pulmonary events and in some cases included rapid tumour lysis and features of tumour lysis syndrome in addition to fever, chills, rigors, hypotension, urticaria, angioedema and other symptoms (see section 4.8).
Danish: Reaktionerne var karakteriseret ved pulmonale hændelser og omfattede i nogle tilfælde hurtig tumorlyse og tegn på tumorlysesyndrom foruden feber, kulderystelser, rigor, hypotension, urticaria, angioødem og andre symptomer (se pkt.
English: In the clinical trial on induction of remission, which included 99 rituximab-treated patients, the overall rate of infection was approximately 237 per 100 patient years (95% CI 197-285) at the 6month primary endpoint.
Danish: I det kliniske studie med induktion af remission, som inkluderede 99 rituximab-behandlede patienter var den samlede infektionshyppighed ca. 237 pr. 100 patientår (95 % konfidensinterval 197-285) ved det primære endepunkt ved måned 6.
English: In addition, other serious viral infections either new, reactivated or exacerbated, some of which were fatal, have been reported with rituximab treatment.
Danish: Derudover er der rapporteret om andre alvorlige virusinfektioner under behandling med rituximab, enten nye, reaktiverede eller recidiverede.
English: Following reconstitution of the immune system in immunocompromised patients with PML,
Danish: Efter rekonstituering af immunsystemet hos immunkomprimerede patienter med PML er der set stabilisering eller forbedret tilstand.
English: Rituximab binding to CD20 antigen on B lymphocytes has also been demonstrated to induce cell death via apoptosis.
Danish: Rituximabs binding til CD20 antigenet på B-lymfocytter har vist også at inducere celledød via apoptose.
English: Physicians should exercise caution when considering the use of rituximab in patients with a history of recurring or chronic infections or with underlying conditions which may further predispose patients to serious infection (see section 4.8).
Danish: Læger bør udvise forsigtighed, når de overvejer brugen af rituximab til patienter, der tidligere har haft recidiverende eller kroniske infektioner eller patienter med tilgrundliggende forhold, der yderligere kan prædisponere dem til alvorlig infektion (se pkt.
English: Psychiatric disorders depression, nervousness,
Danish: Psykiske forstyrrelser depression, nervøsitet
English: In a randomised trial, patients with rheumatoid arthritis treated with rituximab and methotrexate had comparable response rates to tetanus recall antigen (39% vs. 42%), reduced rates to pneumococcal polysaccharide vaccine (43% vs. 82% to at least 2 pneumococcal antibody serotypes), and KLH neoantigen (47% vs. 93%), when given 6 months after rituximab as compared to patients only receiving methotrexate.
Danish: Responsraterne var sammenlignelige ved vaccination med tetanus recall antigen (39 % versus 42 %), der var reduceret respons over for pneumokok polysaccharid vaccine (43 % versus 82 % over for mindst to pneumokokantistof serotyper) og over for KLH neoantigen (47 % versus 93 %), når vaccinationen blev givet 6 måneder efter rituximab-behandling.
English: This is because in a few cases, Ritemvia could cause hepatitis B to become active again, which can be fatal in very rare cases.
Danish: Det er vigtigt, fordi Ritemvia i enkelte tilfælde har forårsaget, at en tidligere leverbetændelse (hepatitis B) er blevet aktiv igen.
English: Clinical experience in pemphigus vulgaris
Danish: Klinisk erfaring ved pemfigus vulgaris
English: The safety profile of rituximab in combination with short-term, low-dose glucocorticoids in the treatment of patients with pemphigus vulgaris was studied in a Phase 3, randomised, controlled, multicenter, open-label study in pemphigus patients that included 38 pemphigus vulgaris (PV) patients randomised to the rituximab group.
Danish: Sikkerhedsprofilen for rituximab i kombination med kortvarig lavdosis glukokortikoider til behandling af patienter med PV blev undersøgt i et randomiseret, kontrolleret, åbent, multicenter fase III-studie, der inkluderede 38 patienter med PV randomiseret til rituximab-gruppen.
English: Nervous system disorders paraesthesia, hypoaesthesia, agitation, insomnia, vasodilatation, dizziness, anxiety dysgeusia peripheral neuropathy, facial nerve palsy5
Danish: Nervesystemet paræstesi, hypoæstesi, agitation, insomni, vasodilatation, svimmelhed, angst dysgeusi perifer neuropati facialisparese5
English: Clear Type I glass vials with butyl rubber stopper containing 100 mg of rituximab in 10 mL.
Danish: Hætteglas, af klart type I glas med butylgummiprop, indeholdende 100 mg rituximab i 10 ml.
English: • Previously untreated follicular lymphoma
Danish: • Tidligere ubehandlet follikulært lymfom
English: Infusion-related reactions In the clinical trial studying induction of remission with severe active GPA and MPA, IRRs were defined as any adverse event occurring within 24 hours of an infusion and considered to be infusion-related by investigators in the safety population.
Danish: Infusionsrelaterede reaktioner i det kliniske studie, hvor man så på induktion af remission hos patienter med svær, aktiv GPA eller MPA blev defineret som enhver bivirkning, der opstod inden for 24 timer efter en infusion i sikkerhedspopulationen, og som af investigator blev anset som værende infusionsrelateret.
English: Patients in both arms received 1000 mg of pulse intravenous (IV) methylprednisolone (or another equivalent-dose glucocorticoid) per day for 1 to 3 days, followed by oral prednisone (1 mg/kg/day, not exceeding 80 mg/day).
Danish: I begge arme fik patienterne intravenøs pulsbehandling med 1000 mg methylprednisolon (eller andet glukokortikoid i ækvivalent dosis) pr. dag i 1-3 dage efterfulgt af oral prednison (1 mg/kg/dag, dog højst 80 mg/dag).
English: Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100) and very rare (< 1/10,000).
Danish: Frekvenserne er defineret som meget almindelig (≥ 1/10), almindelig (≥ 1/100 til < 1/10), ikke almindelig (≥ 1/1.000 til ≤ 1/100) og meget sjælden (< 1/10.000).
English: This syndrome may be associated with some features of tumour lysis syndrome such as hyperuricaemia, hyperkalaemia, hypocalcaemia, hyperphosphataemia, acute renal failure, elevated lactate dehydrogenase (LDH) and may be associated with acute respiratory failure and death.
Danish: Dette syndrom kan ligne kliniske fund på tumorlyse syndrom som hyperuricæmi, hyperkaliæmi, hypocalcæmi, hyperphosphatæmi, akut nyresvigt, forhøjet laktatdehydrogenase (LD) og kan medføre akut respirationssvigt og død.
English: Corticosteroids will usually be given by injection before the start of Ritemvia treatment.
Danish: Du vil som regel få en indsprøjtning med binyrebarkhormon, inden behandlingen med Ritemvia påbegyndes.
English: Non-Hodgkin's lymphoma (NHL)
Danish: Non-Hodgkin-lymfom (NHL)
English: Talk to your doctor, pharmacist or nurse before you are given this medicine if you, or your child, are under 18 years of age.
Danish: Da der er begrænset viden om brug af Ritemvia til børn og unge, skal du kontakte lægen, apotekspersonalet eller sundhedspersonalet inden medicinen gives, hvis du eller dit barn er under 18 år.
English: The two treatment groups were well balanced with regard to baseline characteristics and disease status.
Danish: De to behandlingsgrupper var godt afbalanceret i forhold til baseline karakteristik og sygdomsstatus.
English: In the PV population, 5 (13%) patients in the rituximab group and 3 (8%) patients in the standard prednisone group had moderate disease and 33 (87%) patients in the rituximab group and 33 (92%) patients in the standard-dose prednisone group had severe disease according to disease severity defined by Harman's criteria.
Danish: I PV-populationen havde 5 (13 %) patienter i rituximab-gruppen og 3 (8 %) patienter i standarddosis prednison-gruppen moderat sygdom, og 33 (87 %) patienter i rituximabgruppen og 33 (92 %) patienter i standarddosis prednison-gruppen havde svær sygdom i henhold til sygdomssværhedsgrad defineret ved Harman's kriterier.
English: Progressive multifocal leukoencephalopathy (PML)
Danish: Progressiv multifokal leukoencefalopati
English: Psychiatric disorders depression, anxiety
Danish: Psykiske forstyrrelser depression, angst
English: serious viral infection2 pneumocystis jirovecii
Danish: alvorlig virusinfektion2 pneumocystis jiroveci progressiv multifokal leukoencefalo pati
English: Treatment with rituximab in combination with methotrexate over multiple courses resulted in sustained improvements in the clinical signs and symptoms of RA, as indicated by ACR, DAS28ESR and EULAR responses which was evident in all patient populations studied (Figure 2).
Danish: Gentagne behandlingsserier med rituximab i kombination med methotrexat resulterede i vedvarende forbedringer af kliniske symptomer på RA angivet ved ACR-DAS28-ESR-og EULAR-respons.
English: Experience from rheumatoid arthritis
Danish: Erfaringer med reumatoid artrit
English: Reactivation of hepatitis B infection has also been very rarely reported in rheumatoid arthritis patients receiving rituximab (see section 4.4).
Danish: Der er meget sjældent blevet rapporteret om reaktivering af hepatitis B-infektion hos RA-patienter, som får rituximab (se pkt.
English: Nervous system disorders headache paraesthesia, migraine, dizziness, sciatica
Danish: Nervesystemet hovedpine paræstesi, migræne, svimmelhed, iskias
English: For intravenous use after dilution
Danish: Til intravenøs anvendelse efter fortynding
English: Other symptoms included flushing, angioedema, bronchospasm, vomiting, nausea, urticaria/rash, fatigue, headache, throat irritation, rhinitis, pruritus, pain, tachycardia, hypertension, hypotension, dyspnoea, dyspepsia, asthenia and features of tumour lysis syndrome.
Danish: Andre symptomer omfattede hedeture, angioødem, bronkospasmer, opkastning, kvalme, urticaria/nældefeber, træthed, hovedpine, halsirritation, rhinitis, pruritus, smerter, takykardi, hypertension, hypotension, dyspnø, dyspepsi, asteni og tegn på tumorlysesyndrom.
English: In the induction of remission clinical trial, at 6 months, in the rituximab group, 27%, 58% and 51% of patients with normal immunoglobulin levels at baseline had low IgA, IgG and IgM levels, respectively, compared to 25%, 50% and 46% in the cyclophosphamide group.
Danish: I det kliniske studie med induktion af remission havde henholdsvis 27 %, 58 % og 51 % af patienterne i rituximab-gruppen med normale immunglobulin-niveauer ved baseline lave IgA-, IgG- og IgMniveauer ved måned 6 sammenlignet med henholdsvis 25 %, 50 % og 46 % i cyclophosphamidgruppen.
English: Cardiac events were reported as serious adverse events (including atrial fibrillation, myocardial infarction, left ventricular failure, myocardial ischaemia) in 3% of patients treated with rituximab compared to <1% on observation.
Danish: Kardiale hændelser (herunder atrieflimren, myokardieinfarkt, venstre ventrikulært svigt og myokardieiskæmi) blev rapporteret som alvorlige bivirkninger hos 3 % af patienterne, som fik rituximab sammenlignet med < 1 % i observationsgruppen.
English: The incidence of ADRs of any grade was similar in these two groups.
Danish: Hyppigheden af bivirkninger, uanset sværhedsgrad, var ens i de to grupper.
English: These symptoms are usually reversible with interruption of rituximab infusion and administration of an anti-pyretic, an antihistaminic, and, occasionally, oxygen, intravenous saline or bronchodilators, and glucocorticoids if required.
Danish: Disse symptomer er sædvanligvis reversible, når rituximab-infusionen afbrydes, og der administreres et antipyretikum, et antihistamin og undertiden oxygen, intravenøst saltvand eller bronchodilaterende midler og glukokortikoider om nødvendigt.
English: Fatigue Pyrexia
Danish: Udmattelse Pyreksi
English: The reactions reported were usually reversible with a reduction in rate, or interruption, of rituximab infusion and administration of an anti-pyretic, an antihistamine, and, occasionally, oxygen, intravenous saline or bronchodilators, and glucocorticoids if required.
Danish: De rapporterede reaktioner var som regel reversible efter reduktion af hastigheden eller afbrydelse af rituximab-infusionen og administration af et antipyretikum, et antihistamin og lejlighedsvis oxygen, intravenøs saltvandsopløsning eller bronkodilatorer samt glukokortikoider, hvis det var påkrævet.
English: CHOP, 205 R-CHOP,
Danish: GLSG'00 CHOP, 205 R-CHOP, 223 18
English: All patients treated with rituximab for rheumatoid arthritis, granulomatosis with polyangiitis, microscopic polyangiitis or pemphigus vulgaris must be given the patient alert card with each infusion.
Danish: Alle patienter behandlet med rituximab for reumatoid artrit, GPA, MPA eller PV skal have udleveret patientkortet ved hver infusion.
English: The most common infusion-related reaction symptoms/Preferred Terms included headaches, chills, high blood pressure, nausea, asthenia and pain.
Danish: De mest almindelige symptomer på infusionsrelaterede reaktioner inkluderede hovedpine, kulderystelser, forhøjet blodtryk, kvalme, asteni og smerte.
English: Previously untreated follicular lymphoma
Danish: Tidligere ubehandlet follikulært lymfom
English: Patients randomised to the rituximab group received an initial 1000 mg IV on Study Day 1 and a second 1000 mg IV on Study Day 15.
Danish: De patienter, der blev randomiseret til rituximab-gruppen, fik en initial dosis på 1.000 mg intravenøst på studiedag 1 og endnu en dosis på 1.000 mg intravenøst på studiedag 15.
English: Cardiovascular reactions during clinical trials with rituximab monotherapy were reported in 18.8% of patients with the most frequently reported events being hypotension and hypertension.
Danish: Kardiovaskulære bivirkninger i kliniske studier med rituximab monoterapi blev rapporteret hos 18,8 % af patienterne.
English: Angina pectoris, cardiac arrhythmias such as atrial flutter and fibrillation, heart failure and/or myocardial infarction have occurred in patients treated with rituximab.
Danish: Angina pectoris, hjertearytmier såsom atrieflimren og atrieflagren, hjerteinsufficiens og/eller myokardieinfarkt er forekommet hos patienter behandlet med rituximab.
English: Table 11 Treatment of relapsed/refractory chronic lymphocytic leukaemia - overview of efficacy results for rituximab plus FC vs. FC alone (25.3 months median observation time) Efficacy Parameter
Danish: Tabel 11 Behandling af relapsed/refraktær kronisk lymfatisk leukæmi - sammenfatning af resultaterne for effekt for rituximab plus FC versus FC alene (median observationstid: 25,3 måneder) Effektparameter
English: Experience from pemphigus vulgaris
Danish: Erfaring fra pemfigus vulgaris
English: If you have granulomatosis with polyangiitis, microscopic polyangiitis or pemphigus vulgaris also tell your doctor
Danish: Hvis du har granulomatose med polyangiitis, mikroskopisk polyangiitis fortæl da også din læge eller pemfigus vulgaris
English: 42-months p = 0.029
Danish: 42-måneder p = 0,029
English: Ritemvia can be given alone or with other medicines called “chemotherapy”.
Danish: Ritemvia kan anvendes alene eller sammen med kemoterapi.
English: Concentrate for solution for infusion 500 mg / 50 mL
Danish: Koncentrat til infusionsvæske, opløsning 500 mg/50 ml 1 hætteglas
English: At that time, and within a maximum of 1 month after the last cyclophosphamide pulse, patients were randomly assigned to receive either rituximab (two 500 mg IV infusions separated by two weeks (on Day 1 and Day 15) followed by 500 mg IV every 6 months for 18 months) or azathioprine (administered orally at a dose of 2 mg/kg/day for 12 months, then 1.5 mg/kg/day for 6 months, and finally 1 mg/kg/day for 4 months (treatment discontinuation after these 22 months)).
Danish: Til den tid og inden for højst 1 måned efter den sidste cyclophosphamid pulsbehandling blev patienterne randomiseret til at få enten rituximab (to 500 mg intravenøse infusioner med to ugers mellemrum (på dag 1 og dag 15) efterfulgt af 500 mg intravenøst hver 6. måned i 18 måneder) eller azathioprin (administreret oralt i en dosis på 2 mg/kg/dag i 12 måneder, derefter 1,5 mg/kg/dag i 6 måneder og til sidst 1 mg/kg/dag i 4 måneder (behandlingsophør efter disse 22 måneder)).
English: • ringing sound in the ears, ear pain
Danish: • ringen for ørerne, øresmerter
English: Mean terminal elimination half-life ranged from 15 to 16 days for the 2 × 500 mg dose group and 17 to 21 days for the 2 × 1000 mg dose group.
Danish: Den gennemsnitlige terminale halveringstid for elimination varierede fra 15 til 16 dage for doseringsgruppen 2 x 500 mg og fra 17 til 21 dage for doseringsgruppen 2 x 1.000 mg.
English: Neurologic disorders
Danish: Neurologiske bivirkninger
English: • Relapsed/refractory follicular lymphoma
Danish: • Recidiveret/ refraktært follikulært lymfom
English: +myocardial infarction4 and 6, arrhythmia, +atrial fibrillation, tachycardia, +cardiac
Danish: +myokardieinfarkt4 og 6, arytmier, +atrieflimren, takykardi, +hjertesygdom
English: Rarely fatal cases reported 5 signs and symptoms of cranial neuropathy.
Danish: 5 symptomer på kraniel neuropati.
English: Patients who develop severe cytokine release syndrome should have their infusion interrupted immediately (see section 4.2) and should receive aggressive symptomatic treatment.
Danish: Patienter som udvikler svært cytokinfrigivelsessyndrom bør have deres infusion afbrudt omgående (se pkt.
English: Herpes zoster Nasopharyngitis
Danish: Urinvejsinfektion Bronkitis Herpes zoster Nasofaryngitis
English: Patients with non-Hodgkin's lymphoma should then be evaluated for evidence of tumour lysis syndrome including appropriate laboratory tests and, for pulmonary infiltration, with a chest X-ray.
Danish: Patienter med non-Hodgkin-lymfom skal derefter undersøges for tegn på tumorlysesyndrom, inklusive relevante laboratorieundersøgelser.
English: • difficulty sleeping (insomnia)
Danish: • rastløshed, søvnproblemer
English: Table 10b First-line treatment of chronic lymphocytic leukaemia Hazard ratios of progression-free survival according to Binet stage (ITT) - 48.1 months median observation time
Danish: Tabel 10b Førstelinjebehandling af kronisk lymfatisk leukæmi Hazard ratioer for progressionsfri overlevelse efter Binet stadium (ITT) - median observationstid: 48,1 måneder Progressionsfri overlevelse (PFS)
English: albumin, B symptoms, bulky disease, extranodal sites, bone marrow involvement), the risk ratios for event-free survival and overall survival (R-CHOP compared with CHOP) were less than 0.83 and 0.95 respectively.
Danish: I alle patientundergrupper (køn, alder, aldersjusteret IPI, Ann Arbor stadie, ECOG, β2-mikrobuglobulin, LD, albumin, B-symptomer, udbredt sygdom, ekstranodale lymfomer, knoglemarvspåvirkning) var risikoratioen for hændelsesfri overlevelse og samlet overlevelse (R-CHOP sammenlignet med CHOP) mindre end henholdsvis 0,83 og 0,95.
English: All patients Newly diagnosed n=99 n=48 n=51
Danish: Nyligt diagnosticerede n = 48
English: Cardiac disorders angina pectoris, atrial fibrillation, heart failure, myocardial infarction atrial flutter
Danish: Hjerte angina pectoris, atrieflimren, hjerteinsufficiens, myokardieinfarkt atrieflagren
English: • damage to the intestinal wall (perforation)
Danish: • beskadigelse af tarmvæggen
English: Concentrate for solution for infusion 100 mg / 10 mL
Danish: Koncentrat til infusionsvæske, opløsning 100 mg/10 ml 2 hætteglas
English: The incidence of infusion-related symptoms decreased substantially with subsequent infusions and is < 1% of patients by the eighth cycle of rituximab-containing treatment.
Danish: Hyppigheden af infusionsrelaterede bivirkninger aftog væsentligt med de efterfølgende infusioner og var under 1 % efter den ottende behandlingsserie med rituximab.