FrancophonIA/ELRC3.0 huggingface dataset:
English: For paediatric patients (children and adolescents) weighing less than 47 kg a solution formulation is available.
Croatian: Za pedijatrijske bolesnike (djecu i adolescente) težine manje od 47 kg ovaj je lijek dostupan u obliku otopine.
English: Caution is therefore warranted in the treatment of patients with low CD4 counts.
Croatian: Stoga se nalaže oprez u liječenju bolesnika s malim brojem CD4 stanica.
English: Therefore, it is recommended that renal function be evaluated in all patients prior to initiation of ribavirin.
Croatian: Stoga se preporučuje provjeriti funkciju bubrega u svih bolesnika prije početka liječenja ribavirinom.
English: Ribavirin Teva Pharma B.V. is available in different pack sizes containing 14, 28, 42, 56, 84, 112, 140 or 168 tablets.
Croatian: Ribavirin Teva Pharma B.V. je dostupan u različitim veličinama pakiranja koja sadrže 14, 28, 42, 56, 84, 112, 140 ili 168 tableta.
English: Prior to initiation of treatment with ribavirin the physician must comprehensively inform both male and female patients of the teratogenic risk of ribavirin, the necessity of effective and continuous contraception, the possibility that contraceptive methods may fail and the possible consequences of pregnancy should it occur during or following treatment with ribavirin (see section 4.6).
Croatian: Prije početka liječenja ribavirinom, liječnik mora i bolesnicima i bolesnicama detaljno objasniti teratogeni rizik primjene ribavirina, potrebu za učinkovitom i kontinuiranom kontracepcijom, mogućnost neuspjeha kontracepcijskih metoda i moguće posljedice trudnoće ako ona nastupi tijekom ili nakon liječenja ribavirinom (vidjeti dio 4.6).
English: The purpose of the studies was to evaluate the durability of sustained virologic response (SVR) and assess the impact of continued viral negativity on clinical outcomes.
Croatian: Svrha ispitivanja bila je procjena postojanosti trajnog virološkog odgovora (SVR) i utjecaja kontinuirano negativnog nalaza virusa na klinički ishod.
English: Clearance increased as a function of body weight and was reduced at ages greater than 40 years.
Croatian: Klirens se povećavao s povećanjem tjelesne težine, a bio je smanjen u bolesnika starijih od 40 godina.
English: You must have a negative pregnancy test before treatment, each month during treatment, and for the 4 months after treatment is stopped.
Croatian: Morate imati negativan test na trudnoću prije liječenja, svaki mjesec tijekom liječenja i tijekom 4 mjeseca nakon prestanka liječenja.
English: 1 tablet in the morning and 2 tablets in the evening
Croatian: 1 tableta ujutro i 2 tablete navečer
English: In the pivotal clinical efficacy trial, patients were instructed to take ribavirin with food to achieve the maximal plasma concentration of ribavirin.
Croatian: U pivotalnom kliničkom ispitivanju djelotvornosti bolesnicima se savjetovalo da uzimaju ribavirin s hranom kako bi se postigle maksimalne koncentracije ribavirina u plazmi.
English: Transfer into seminal fluid
Croatian: Prijenos u sjemenu tekućinu
English: Results of these investigations showed that ribavirin monotherapy had no effect on eliminating hepatitis virus (HCV-RNA) or improving hepatic histology after 6 to 12 months of therapy and 6 months of follow-up.
Croatian: Rezultati tih ispitivanja pokazali su da monoterapija ribavirinom nije imala učinka na uklanjanje virusa hepatitisa (HCV-RNK) niti na poboljšanje histološkog stanja jetre nakon 6 do 12 mjeseci liječenja i 6 mjeseci naknadnog praćenja.
English: Ribavirin (800 mg/day)
Croatian: Ribavirin (800 mg/dan)
English: There is a linear relationship between dose and AUCtf following single doses of 200-1,200 mg ribavirin.
Croatian: Odnos između doze i AUCtf je linearan nakon primjene jednokratnih doza od 200 do 1200 mg ribavirina.
English: Please refer to the Package Leaflet of (peg)interferon alfa for more detailed information on these safety issues.
Croatian: Molimo pročitajte Uputu o lijeku za (peg)interferon alfa za detaljnije informacije o tim sigurnosnim problemima.
English: Due to the risk of lactic acidosis (a build-up of lactic acid in the body) and pancreatitis, the use of ribavirin and didanosine is not recommended and the use of ribavirin and stavudine should be avoided.
Croatian: Zbog rizika od laktacidoze (nakupljanje mliječne kiseline u tijelu) i upale gušterače, ne preporučuje se istodobna primjena ribavirina i didanozina, a istodobnu primjenu ribavirina i stavudina treba izbjegavati.
English: Ribavirin has two pathways of metabolism: 1) a reversible phosphorylation pathway; 2) a degradative pathway involving deribosylation and amide hydrolysis to yield a triazole carboxyacid metabolite.
Croatian: Ribavirin ima dva metabolička puta: 1) put reverzibilne fosforilacije i 2) put razgradnje koji uključuje deribozilaciju i hidrolizu amida, u kojem nastaje metabolit triazol karboksilna kiselina.
English: Acute hypersensitivity
Croatian: Akutna preosjetljivost
English: In addition, injection site disorders, pyrexia, anorexia, vomiting, and emotional lability occurred more frequently in children and adolescents compared to adult patients.
Croatian: Osim toga, promjene na mjestu injekcije, pireksija, anoreksija, povraćanje i emocionalna labilnost javljali su se češće u djece i adolescenata nego u odraslih bolesnika.
English: Any patient developing significant liver function abnormalities during treatment must be monitored closely.
Croatian: Svaki bolesnik koji razvije značajne poremećaje funkcije jetre tijekom liječenja mora se strogo nadzirati.
English: 2 tablets in the morning and 2 tablets in the evening or 1 (400 mg) tablet in the morning and 1 (400 mg) tablet in the evening See adult dose
Croatian: 2 tablete ujutro i 2 tablete navečer ili 1 (400 mg) tableta ujutro i 1 (400 mg) tableta navečer
English: Although, the majority of them could be managed by dose reduction, close monitoring of haematological parameters should be undertaken in this population of patients (see section 4.2 and below “Laboratory tests” and section 4.8).
Croatian: Premda se većina tih poremećaja može zbrinuti smanjivanjem doze, potrebno je pažljivo nadzirati hematološke parametre u ovoj populaciji bolesnika (vidjeti dio 4.2, "Laboratorijski nalazi" u nastavku te dio 4.8).
English: Ribavirin Teva Pharma B.V. must be used in combination therapy as described in section 4.1.
Croatian: Ribavirin Teva Pharma B.V. se mora primjenjivati u kombiniranoj terapiji kao što je opisano u dijelu 4.1.
English: Nephrotic syndrome*
Croatian: nefrotski sindrom*
English: • are a male and your female partner is of childbearing age (see section “Pregnancy and breast feeding”).
Croatian: • muškarac, a Vaša partnerica je u reproduktivnoj dobi (vidjeti dio "Trudnoća i dojenje").
English: Although ribavirin has no direct cardiovascular effects, anaemia associated with ribavirin may result in deterioration of cardiac function, or exacerbation of the symptoms of coronary disease, or both.
Croatian: Iako ribavirin nema izravnih kardiovaskularnih učinaka, anemija povezana s ribavirinom može dovesti do slabljenja srčane funkcije ili pogoršanja simptoma koronarne bolesti, ili oboje.
English: Adult patients with a history of congestive heart failure, myocardial infarction and/or previous or current arrhythmic disorders must be closely monitored.
Croatian: Odrasle bolesnike s kongestivnim zatajenjem srca ili infarktom miokarda u anamnezi i/ili prethodnim ili postojećim poremećajima srčanog ritma mora se pomno nadzirati.
English: Because of the potential for adverse reactions in breast-fed infants, breast-feeding must be discontinued prior to initiation of treatment.
Croatian: Zbog mogućnosti razvoja nuspojava u dojenčadi dojenje se mora prekinuti prije početka liječenja.
English: If your female partner is not pregnant now but is of childbearing age, she must be tested for pregnancy each month during treatment and for the 7 months after treatment has stopped.
Croatian: Ako Vaša partnerica nije trudna, ali je u reproduktivnoj dobi, mora napraviti test na trudnoću svaki mjesec za vrijeme Vašeg liječenja te tijekom 7 mjeseci nakon prestanka liječenja.
English: Pharmacologically, ribavirin increases phosphorylated metabolites of purine nucleosides in vitro.
Croatian: Farmakološki, ribavirin dovodi do porasta fosforiliranih metabolita purinskih nukleozida in vitro.
English: Ribavirin does not inhibit cytochrome P450 enzymes.
Croatian: Ribavirin ne inhibira enzime citokroma P450.
English: Sustained virological response in previously untreated children and adolescents
Croatian: Tablica 9 Trajan virološki odgovor u djece i adolescenata koji prethodno nisu bili liječeni
English: Absorption is extensive with approximately 10 % of a radiolabelled dose excreted in the faeces.
Croatian: Apsorpcija je opsežna, a oko 10% radioaktivno označene doze izlučuje se fecesom.
English: Upon cessation of treatment, essentially total recovery from ribavirin-induced testicular toxicity occurred within one or two spermatogenic cycles (see section 4.6).
Croatian: Nakon prestanka liječenja dolazi do zapravo potpunog oporavka od testikularne toksičnosti izvazvane ribavirinom unutar jednog ili dva ciklusa spermatogeneze (vidjeti dio 4.6).
English: Neuropathy, peripheral neuropathy
Croatian: neuropatija, periferna neuropatija rijetko:
English: The safety and efficacy of ribavirin used together with direct-acting-anti-virals in these patients has not been established.
Croatian: Sigurnost i djelotvornost ribavirina u kombinaciji s antiviroticima koji djeluju direktno nisu ustanovljene u tih bolesnika.
English: Daily ribavirin dose
Croatian: Dnevna doza ribavirina
English: Dose modification for paediatric patients
Croatian: Prilagodba doze u pedijatrijskih bolesnika
English: There does not appear to be a significant age-related effect on the pharmacokinetics of ribavirin.
Croatian: Čini se da dob nema značajnog utjecaja na farmakokinetiku ribavirina.
English: Dosing of ribavirin for children and adolescent patients is determined by the patient body weight.
Croatian: Doziranje ribavirina za djecu i adolescente utvrđuje se na osnovi tjelesne težine bolesnika.
English: • are a woman of childbearing age (see section “Pregnancy and breast-feeding”).
Croatian: • žena u reproduktivnoj dobi (vidjeti dio "Trudnoća i dojenje").
English: The decline of height, weight and BMI Z scores observed during the treatment phase in comparison to a normative population did not fully recover at the end of long-term follow-up period for children treated with 48 weeks of therapy (see section 4.4).
Croatian: Smanjenje Z-vrijednosti za visinu, tjelesnu težinu i BMI primijećeno tijekom razdoblja liječenja u usporedbi s normativnom populacijom nije se potpuno oporavilo do kraja razdoblja dugotrajnog praćenja u djece liječene 48 tjedana (vidjeti dio 4.4).
English: For children or adolescents who cannot swallow a film-coated tablet, an oral solution of ribavirin is available.
Croatian: Za djecu ili adolescente koji ne mogu progutati filmom obloženu tabletu, ribavirin je dostupan u obliku oralne otopine.
English: This appears to be due to reduction of apparent clearance in these patients.
Croatian: Čini se da je to posljedica smanjenog prividnog klirensa u tih bolesnika.
English: Brampton Road, Hampden Park, Eastbourne, East Sussex, BN22 9AG United Kingdom
Croatian: Brampton Road, Hampden Park, Eastbourne, East Sussex, BN22 9AG Ujedinjeno Kraljevstvo
English: Sustained response was assessed by the response rate six months after the cessation of treatment.
Croatian: 1. Trajan odgovor na liječenje procijenjen je na temelju stope odgovora 6 mjeseci nakon prestanka liječenja.
English: If pregnancy does occur during treatment or within four months from stopping treatment, the patient must be advised of the significant teratogenic risk of ribavirin to the foetus (see section 4.4).
Croatian: Ako bolesnica zatrudni tijekom liječenja ili unutar četiri mjeseca po prestanku liječenja, mora biti obaviještena o značajnom teratogenom riziku ribavirina za fetus (vidjeti dio 4.4).
English: In subjects with creatinine clearance between 30 and 50 mL/min, AUCtf was twofold greater compared with control subjects.
Croatian: U ispitanika s klirensom kreatinina između 30 i 50 ml/min, AUCtf bio je dvostruko veći nego u kontrolnih ispitanika.
English: Table 2 Management of Adverse Reactions Laboratory values
Croatian: Tablica 2 Zbrinjavanje nuspojava Laboratorijske vrijednosti
English: There is no evidence that ribavirin interacts with non-nucleoside reverse transcriptase inhibitors or protease inhibitors.
Croatian: Nema dokaza o postojanju interakcija između ribavirina i nenukleozidnih inhibitora reverzne transkriptaze ili inhibitora proteaze.
English: However, ribavirin systemic exposure of a female partner after sexual intercourse with a treated patient has been estimated and remains extremely limited compared to therapeutic plasma concentration of ribavirin.
Croatian: Međutim, procijenjena je sistemska izloženost ribavirinu u partnerice nakon spolnog odnosa s liječenim bolesnikom, koja je i dalje iznimno mala u usporedbi s terapijskom koncentracijom ribavirina u plazmi.
English: At the end of 5 years, 85 % (80/94) of all enrolled subjects and 86 % (54/63) of sustained responders completed the study.
Croatian: Nakon 5 godina ispitivanje je završilo 85% (80/94) svih uključenih bolesnika te 86% (54/63) ispitanika s trajnim odgovorom.
English: No pharmacokinetic interaction appears between ribavirin and hepatic function (see section 5.2).
Croatian: Čini se da nema farmakokinetičke interakcije između ribavirina i funkcije jetre (vidjeti dio 5.2).
English: In addition, in a 26 week carcinogenicity study using the heterozygous p53(+/-) mouse model, ribavirin did not produce tumours at the maximally tolerated dose of 300 mg/kg (plasma exposure factor approximately 2.5 compared to human exposure).
Croatian: Osim toga, u 26-tjednom ispitivanju kancerogenosti na heterozigotnom mišjem modelu p53(+/-) ribavirin nije prouzročio tumore pri maksimalnoj podnošljivoj dozi od 300 mg/kg (faktor plazmatske izloženosti bio je oko 2,5 puta veći u usporedbi s izloženošću u ljudi).
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Immediate packaging (blister foil)
Croatian: PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP Unutarnje pakiranje (blister folija)
English: Ribavirin concentrations are essentially unchanged by haemodialysis.
Croatian: Koncentracije ribavirina nisu se bitno promijenile hemodijalizom.
English: • have problems with your kidneys.
Croatian: • imate tegoba s bubrezima
English: Female: dysmenorrhoea
Croatian: Žene: dismenoreja
English: > 5 mg/dL (for > 4 weeks) (children and adolescents treated with interferon alfa-2b), or > 4 mg/dL (for > 4 weeks) (children and adolescents treated with peginterferon alfa-2b)
Croatian: >5 mg/dl (tijekom >4 tjedna) (djeca i adolescenti liječeni interferonom alfa-2b) ili >4 mg/dl (tijekom >4 tjedna) (djeca i adolescenti liječeni peginterferonom alfa-2b)
English: Patients with impaired renal function should be more carefully monitored with respect to the development of anaemia.
Croatian: Bolesnici s oštećenom funkcijom bubrega moraju se pažljivije nadzirati zbog mogućeg razvoja anemije.
English: The decision to treat should be made on a case by case.
Croatian: Odluku o liječenju potrebno je donijeti za svakog bolesnika pojedinačno.
English: Furthermore, suicidal ideation or attempts were reported more frequently compared to adult patients (2.4 % vs 1 %) during treatment and during the 6 month follow-up after treatment.
Croatian: Nadalje, suicidalne misli ili pokušaji samoubojstva su tijekom liječenja i tijekom šestomjesečnog praćenja nakon liječenja prijavljeni češće nego u odraslih bolesnika (2,4% u odnosu na 1%).
English: Ribavirin has been shown to produce high inter and intra subject pharmacokinetic variability following single oral doses (intrasubject variability of approximately 30 % for both AUC and Cmax), which may be due to extensive first pass metabolism and transfer within and beyond the blood compartment.
Croatian: Ribavirin iskazuje veliku interindividualnu i intraindividualnu farmakokinetičku varijabilnost nakon primjene jedne peroralne doze (intraindividualna varijabilnost iznosi približno 30% i za AUC i za Cmax), što može biti posljedica opsežnog metaboliziranja prilikom prvog prolaza i prijelaza unutar i izvan krvnog odjeljka.
English: Reports of mitochondrial toxicity, in particular lactic acidosis and pancreatitis, of which some fatal, have been reported (see section 4.4).
Croatian: Prijavljeni su slučajevi mitohondrijske toksičnosti, osobito laktacidoze i pankreatitisa, od kojih su neki imali smrtni ishod (vidjeti dio 4.4).
English: The bioavailability of ribavirin 600 mg was decreased by co-administration with an antacid containing magnesium aluminium and simethicone; AUCtf decreased 14 %.
Croatian: Bioraspoloživost doze ribavirina od 600 mg bila je smanjena prilikom istodobne primjene antacida koji sadrže magnezij, aluminij i simetikon; AUCtf se smanjio za 14%.
English: It is recommended that those patients who have pre-existing cardiac abnormalities have electrocardiograms taken prior to and during the course of treatment.
Croatian: U bolesnika s već postojećim srčanim poremećajima preporučuje se snimiti elektrokardiograme prije i tijekom liječenja.
English: Ribavirin is absorbed rapidly following oral administration of a single dose (mean Tmax=1.5 hours), followed by rapid distribution and prolonged elimination phases (single dose half-lives of absorption, distribution and elimination are 0.05, 3.73 and 79 hours, respectively).
Croatian: Nakon peroralne primjene jedne doze ribavirin se brzo apsorbira (prosječan Tmax = 1,5 sati), nakon čega slijedi brza raspodjela i produljena faza eliminacije (nakon jedne doze poluvrijeme apsorpcije iznosi 0,05 sati, poluvrijeme distribucije 3,73 sata, a poluvrijeme eliminacije 79 sati).
English: Conflicting findings are reported in literature on co-administration between abacavir and ribavirin.
Croatian: U literaturi su prijavljena proturječna izvješća u vezi istodobne primjene abakavira i ribavirina.
English: Additionally, patients receiving zidovudine with ribavirin in combination with alpha interferons could be at increased risk of developing anaemia (low number of red blood cells).
Croatian: Osim toga, bolesnici koji se liječe zidovudinom i ribavirinom u kombinaciji s alfa interferonima mogu imati povećan rizik za razvoj anemije (mali broj crvenih krvnih stanica).
English: CD4 lymphocytes decrease
Croatian: Smanjenje broja CD4 limfocita
English: The pharmacokinetics of ribavirin and interferon alfa-2b (dose-normalized) is similar in adults and children or adolescents.
Croatian: Farmakokinetika ribavirina i interferona alfa-2b (normalizirana po dozi) slična je u odraslih i djece ili adolescenata.
English: HCV genotype and baseline virus load are prognostic factors which are known to affect response rates.
Croatian: HCV genotip i početno virusno opterećenje poznati su prognostički čimbenici koji utječu na stope odgovora na liječenje.
English: Pharma B.V. must not be initiated until a report of a negative pregnancy test has been obtained immediately prior to initiation of therapy.
Croatian: Teva Pharma B.V. ne smije se započeti dok se ne dobije negativan rezultat testa na trudnoću neposredno prije početka liječenja.
English: Genotoxic activity was observed in the mouse lymphoma assay, and at doses of 20-200 mg/kg in a mouse micronucleus assay.
Croatian: Genotoksična aktivnost primijećena je u testu s mišjim limfomom te pri dozama od 20-200 mg/kg u mikronukleusnom testu na miševima.
English: - Teratogenicity: Significant teratogenic and/or embryocidal potential have been demonstrated for ribavirin in all animal species in which adequate studies have been conducted, occurring at doses as low as one twentieth of the recommended human dose (see section 5.3).
Croatian: - Teratogenost: ribavirin je pokazao značajan teratogeni i/ili embriocidni potencijal u svih životinjskih vrsta na kojima su provedena odgovarajuća ispitivanja, pri dozama koje su iznosile samo 1/20 doze koja se preporučuje u ljudi (vidjeti dio 5.3).
English: The duration of therapy was 48 weeks with a follow-up period of 6 months except for patients infected with genotypes 2 or 3 and viral load < 800,000 IU/mL (Amplicor) who were treated for 24 weeks with a 6 month follow-up period.
Croatian: Liječenje je trajalo 48 tjedana, a razdoblje naknadnog praćenja 6 mjeseci, osim u bolesnika inficiranih genotipovima 2 ili 3 i virusnim opterećenjem <800 000 IU/ml (Amplicor) koji su liječeni 24 tjedna i naknadno praćeni 6 mjeseci.
English: Antacid
Croatian: Antacidi
English: Facial palsy, mononeuropathies
Croatian: facijalna paraliza, mononeuropatije
English: Females of childbearing potential must use an effective contraceptive during treatment and for four months after treatment has been concluded; routine monthly pregnancy tests must be performed during this time (see section 4.4).
Croatian: Žene reproduktivne dobi moraju koristiti pouzdanu kontracepciju za vrijeme liječenja i tijekom 4 mjeseca nakon završetka liječenja; svakog se mjeseca tijekom navedenog perioda moraju rutinski obavljati testovi na trudnoću (vidjeti dio 4.4).
English: Preclinical data: - Fertility: In animal studies, ribavirin produced reversible effects on spermatogenesis (see section
Croatian: Pretklinički podaci: - Plodnost: u istraživanjima na životinjama ribavirin je imao reverzibilne učinke na spermatogenezu (vidjeti dio 5.3).
English: If an acute hypersensitivity reaction (e.g., urticaria, angioedema, bronchoconstriction, anaphylaxis) develops, Ribavirin Teva Pharma B.V. must be discontinued immediately and appropriate medical therapy instituted.
Croatian: Ako se razvije akutna reakcija preosjetljivosti (npr. urtikarija, angioedem, bronhokonstrikcija, anafilaksija), odmah se mora prekinuti davanje lijeka Ribavirin Teva Pharma B.V. i započeti odgovarajuće liječenje.
English: • Psychiatric and central nervous system effects (such as depression, suicidal thoughts, attempted suicide and aggressive behaviour, etc.).
Croatian: • psihijatrijske učinke i učinke na središnji živčani sustav (poput depresije, razmišljanja o samoubojstvu, pokušaja samoubojstva i agresivnog ponašanja itd.).
English: Ribavirin Teva Pharma B.V. tablets are to be administered orally each day in two divided doses (morning and evening) with food.
Croatian: Ribavirin Teva Pharma B.V. tablete primjenjuju se peroralno svakoga dana, u dvije podijeljene doze (ujutro i navečer), uz obrok.
English: Important treatment-emergent adverse reactions that occurred in this patient population were nervousness (8 %), aggression (3 %), anger (2 %), depression/depressed mood (4 %) and hypothyroidism (3 %) and 5 subjects received levothyroxine treatment for hypothyroidism/elevated TSH.
Croatian: Važne nuspojave koje su se pojavile tijekom liječenja u ovoj populaciji bolesnika bile su nervoza (8%), agresivnost (3%), ljutnja (2%), depresija/depresivno raspoloženje (4%) i hipotireoza (3%), a pet je ispitanika uzimalo levotiroksin za liječenje hipotireoze/povišenih razina TSH-a.
English: In the HIV-positive population receiving an NRTI regimen, physicians should carefully monitor markers of mitochondrial toxicity and lactic acidosis when ribavirin is administered.
Croatian: U HIV-pozitivnoj populaciji koja prima režim s NRTI liječnici moraju pažljivo nadzirati markere mitohondrijske toksičnosti i laktacidoze za vrijeme primjene ribavirina.
English: Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V.
Croatian: Od zdrastvenih radnika se traži da prijave svaku sumnju na nuspojavu lijeka putem nacionalnog sustava prijave nuspojava navedenog u Dodatku V*.
English: Laboratory tests
Croatian: Laboratorijski nalazi
English: However, as in younger patients, renal function must be determined prior to administration of ribavirin (see section 5.2).
Croatian: Međutim, jednako kao i u mlađih bolesnika, prije primjene ribavirina mora se utvrditi funkcija bubrega (vidjeti dio 5.2).
English: Specific pharmacokinetic evaluations for elderly subjects have not been performed.
Croatian: Nisu provedena posebna ispitivanja farmakokinetike ribavirina za starije bolesnike.