FrancophonIA/ELRC3.0 huggingface dataset:
English: Post-Exposure-Prophylaxis: Serious hepatotoxicity, including liver failure requiring transplantation, has been reported in HIV-uninfected individuals receiving multiple doses of nevirapine in the setting of post-exposure-prophylaxis (PEP), an unapproved use.
Danish: leversvigt påkrævende transplantation, er blevet rapporteret hos ikke hiv-smittede personer, som fik multiple doser af nevirapin i forbindelse med post-eksponeringsprofylakse (PEP), en ikke godkendt anvendelse.
English: Itraconazole AUC ↓ 0.39
Danish: Itraconazol AUC ↓ 0,39
English: Cobicistat, a cytochrome P450 3A inhibitor significantly inhibits hepatic enzymes, as well as other metabolic pathways.
Danish: Cobicistat, en CYP-3A-hæmmer, hæmmer signifikant leverenzymer, samt andre metaboliseringsveje.
English: If you are receiving post-menopausal hormone therapy, ask your doctor for advice before taking this medicine.
Danish: Hvis du bruger post-menopausal hormonbehandling, skal du spørge din læge til råds, før du tager Nevirapin Teva.
English: Lopinavir/ritonavir (oral solution) 300/75 mg/m2 BID
Danish: Lopinavir/ritonavir (oral opløsning) 300/75 mg/m2 to
English: You should continue to take Nevirapine Teva for as long as instructed by your doctor.
Danish: Du skal fortsætte behandlingen med Nevirapin Teva så længe, som din læge har foreskrevet.
English: Taking all doses at the appropriate times: - greatly increases the effectiveness of your combination antiretroviral medicines.
Danish: Når man tager alle doser på det rigtige tidspunkt - så øger det i høj grad effekten af kombinationsbehandlingen - mindsker risikoen for at hiv-infektionen bliver resistent over for den antiretrovirale behandling.
English: Co-administration of Nevirapine Teva with elvitegravir in combination with cobicistat is not recommended (see section 4.4).
Danish: Co-administration af Nevirapin Teva og elvitegravir i kombination med cobicistat kan ikke anbefales (se pkt.
English: Nevirapine Teva 200 mg
Danish: Nevirapin Teva 200 mg
English: If you are taking oral contraceptives (e.g. “pill“) or other hormonal methods of birth control during treatment with Nevirapine Teva you should use a barrier contraception (e.g. condoms) in addition to prevent pregnancy and further HIV transmission.
Danish: Hvis du bruger p-piller eller andre hormonelle præventionsmetoder under behandling med Nevirapin Teva, bør du samtidig bruge kondom for at beskytte mod graviditet og overførsel af smitte.
English: Nevirapine Cmin ↑ 1.07
Danish: Nevirapin Cmin ↑ 1,07
English: Nevirapine must be permanently discontinued in any patient experiencing severe rash or a rash accompanied by constitutional symptoms (such as fever, blistering, oral lesions, conjunctivitis, facial oedema, muscle or joint aches, or general malaise), including Stevens-Johnson syndrome, or toxic epidermal necrolysis.
Danish: Nevirapin skal seponeres permanent hos enhver patient, som udvikler et alvorligt udslæt eller udslæt ledsaget af konstitutionelle symptomer (såsom feber, blæredannelse, orale læsioner, conjunctivitis, ødemer i ansigt, muskel- eller ledsmerter eller generel utilpashed) inklusive Stevens-Johnsons syndrom eller toksisk epidermal nekrolyse.
English: Nevirapine is contraindicated in patients with severe hepatic impairment (Child-Pugh C, see section 4.3).
Danish: Nevirapin er kontraindiceret hos patienter med alvorlig hepatisk insufficiens (Child-Pugh C, se pkt.
English: Ketoconazole Cmax ↓ 0.56 (0.42
Danish: Ketoconazol Cmax ↓ 0,56 (0,42
English: compared with historical data where nevirapine was administered alone.
Danish: Nevirapin eksponering: ↑100 % sammenlignet med historiske data, hvor nevirapin blev administreret alene.
English: Enfuvirtide
Danish: Enfuvirtid
English: Other medicines and Nevirapine Teva
Danish: Brug af anden medicin sammen med Nevirapin Teva
English: Common (may affect up to 1 in 10 people): - decreased numbers of white blood cells (granulocytopenia) - allergic reactions (hypersensitivity) - headache - feeling sick (nausea) - vomiting - abdominal pain - loose stools (diarrhoea) - inflammation of the liver (hepatitis) - feeling tired (fatigue) - fever - abnormal liver function tests
Danish: Almindelig (kan forekomme hos op til 1 ud af 10 patienter): - nedsat antal hvide blodlegemer (granulocytopeni) - allergiske reaktioner (overfølsomhed) - hovedpine - kvalme - opkastning - mavesmerter - løs afføring (diarré) - leverbetændelse (hepatitis) - udmattelse - feber - leverfunktionsprøver uden for normalområdet
English: This herbal substance may stop Nevirapine Teva from working properly.
Danish: Dette naturlægemiddel kan medføre, at Nevirapin Teva ikke virker optimalt.
English: For patients with renal dysfunction requiring dialysis an additional 200 mg dose of nevirapine following each dialysis treatment is recommended.
Danish: Patienter med nedsat nyrefunktion, som har behov for dialyse, bør efter hver dialysebehandling have en ekstra dosis på 200 mg nevirapin.
English: The side effects described below have been experienced by patients given nevirapine:
Danish: Bivirkningerne nedenfor er set hos patienter, der er behandlet med Nevirapin Teva:
English: If patients present with a suspected nevirapine-associated rash, liver function tests should be performed.
Danish: Hvis patienter udvikler et udslæt, der kan være forbundet med nevirapin, bør der udføres levertests.
English: - St John's Wort (Hypericum perforatum, medicine to treat depression) - rifampicin (medicine to treat tuberculosis) - rifabutin (medicine to treat tuberculosis) - macrolides e.g. clarithromycin (medicine to treat bacterial infections) - fluconazole (medicine to treat fungal infections) - ketoconazole (medicine to treat fungal infections) - itraconazole (medicine to treat fungal infections) - methadone (medicine used for treatment of opiate addicts) - warfarin (medicine to reduce blood clotting) - hormonal contraceptives (e.g. the “pill”) - atazanavir (another medicine to treat HIV-infection) - lopinavir/ritonavir (another medicine to treat HIV-infection) - fosamprenavir (another medicine to treat HIV-infection) - efavirenz (another medicine to treat HIV-infection) - etravirine (another medicine to treat HIV-infection) - rilpivirine (another medicine to treat HIV-infection) - delavirdine (another medicine to treat HIV-infection) - zidovudine (another medicine to treat HIV-infection) - boceprevir (medicine to treat hepatitis C) - telaprevir (medicine to treat hepatitis C) - elvitegravir/cobicistat (another medicine to treat HIV-infection)
Danish: - warfarin (antikoagulant-blodfortyndende) - hormonale antikonceptionsmidler, f.eks. p-piller - atazanavir (mod hiv-infektion) - lopinavir/ritonavir (mod hiv-infektion) - fosamprenavir (mod hiv-infektion) - efavirenz (mod hiv-infektion) - etravirin (mod hiv-infektion) - rilpivirin (mod hiv-infektion) - delavirdin (mod hiv-infektion) - zidovudine (mod hiv-infektion) - boceprevir (mod hepatitis C) - telaprevir (mod hepatitis C) - elvitegravir/cobicistat (mod hiv-infektion).
English: Women of childbearing potential should not use oral contraceptives as the sole method for birth control, since nevirapine might lower the plasma concentrations of these medicinal products (see sections 4.4 & 4.5).
Danish: Kvinder i den fødedygtige alder bør ikke udelukkende anvende oral antikonception som antikonception, idet nevirapin kan nedsætte plasmakoncentrationen af disse lægemidler (se pkt.
English: In a retrospective review of predominantly patients with a plasma HIV-1 viral load of 50 copies/ml or higher, women with CD4 counts > 250 cells/mm3 had a 12 fold higher risk of symptomatic hepatic adverse reactions compared to women with CD4 counts < 250 cells/mm3 (11.0 %
Danish: Ved en retrospektiv gennemgang af data fra især patienter med et hiv-1 viralt plasmaniveau på 50 kopier/ml eller flere, havde kvinder med CD4-celletal > 250 celler/mm3 12 gange større risiko for symptomatiske leverpåvirkning sammenlignet med kvinder med CD4-celletal < 250 celler/mm3 (11,0 % versus 0,9 %).
English: If a hypersensitivity reaction occurs, characterised by rash with constitutional symptoms such as fever, arthralgia, myalgia and lymphadenopathy, plus visceral involvement, such as hepatitis, eosinophilia, granulocytopenia, and renal dysfunction, nevirapine must be permanently stopped and not be reintroduced (see section 4.3).
Danish: Hvis overfølsomhedsreaktioner opstår, kendetegnet ved udslæt med konstitutionelle symptomer såsom feber, artralgi, myalgi og lymfadenopati samt organpåvirkning, såsom hepatitis, eosinofili, granulocytopeni og nyresvigt, skal nevirapin stoppes permanent og ikke genintroduceres (se pkt.
English: Additionally, when postmenopausal hormone therapy is used during administration of nevirapine, its therapeutic effect should be monitored.
Danish: Ved postmenopausal hormonbehandling bør den terapeutiske virkning monitoreres, når der samtidig behandles med nevirapin.
English: The postmarketing experience has shown that the most serious adverse reactions are Stevens-Johnson syndrome/ toxic epidermal necrolysis, serious hepatitis/hepatic failure, and drug reaction with eosinophilia and systemic symptoms, characterised by rash with constitutional symptoms such as fever, arthralgia, myalgia and lymphadenopathy, plus visceral involvement, such as hepatitis, eosinophilia, granulocytopenia, and renal dysfunction.
Danish: Postmarketing-erfaring har vist, at de alvorligste bivirkninger er Stevens-Johnsons syndrom/toksisk epidermal nekrolyse, alvorlig hepatitis/leversvigt og lægemiddelreaktion med eosinofili og systemiske symptomer, kendetegnet ved udslæt med konstitutionelle symptomer, såsom feber, artralgi, myalgi,
English: Furthermore, in the case nevirapine is used as single dose to prevent vertical transmission of HIV-1 infection, the risk of hepatotoxicity in mother and child cannot be excluded.
Danish: Endvidere kan risikoen for hepatotoksicitet hos mor og barn ikke udelukkes i de tilfælde, hvor nevirapin gives som enkeltdosis for at forebygge vertikal transmission af hiv-1-infektion.
English: Weight and levels of blood lipids and glucose may increase during antiretroviral therapy (see section 4.4)
Danish: Kropsvægt og lipid og glucose-koncentrationerne i blodet kan stige under antiretroviral behandling (se pkt.
English: Clarithromycin 500 mg BID
Danish: Clarithromycin 500 mg 2 gange daglig
English: If you experience severe rash or hypersensitivity (allergic reactions that may appear in the form of rash) accompanied by other side effects such as - fever, - blistering, - mouth sores, - inflammation of the eye, - swelling of the face, - general swelling, - shortness of breath, - muscle or joint pain, - general feelings of illness, - or abdominal pain
Danish: Hvis du får alvorlige hududslæt eller overfølsomhedsreaktioner (allergiske reaktioner) som kan forekomme i form af hududslæt, samtidig med andre bivirkninger såsom - feber - blæredannelser - sår i munden - øjenbetændelse - hævelser i ansigtet - generelle hævelser - åndenød - muskel- eller ledsmerter - en følelse af at være syg - eller mavesmerter
English: In study 1100.1090, from which the majority of related adverse events (n=28) were received, patients on placebo had a higher incidence of events of granulocytopenia (3.3%) than patients on nevirapine
Danish: I studie 1100.1090 blev bivirkningen granolucytopeni (n=28) rapporteret hyppigere i placebogruppen (3,3%) end i nevirapingruppen (2,5%).
English: The patients studied were receiving antiretroviral therapy containing nevirapine 200 mg twice daily for at least 6 weeks prior to pharmacokinetic sampling, with a median duration of therapy of 3.4 years.
Danish: Patienterne havde haft en gennemsnitlig behandlingsvarighed på 3,4 år med antiviral behandling inkluderende nevirapin 200 mg 2 gange dagligt i 6 uger inden de farmakokinetiske prøver blev taget.
English: Fluconazole AUC ↔ 0.94 (0.88
Danish: Fluconazol AUC ↔ 0,94 (0,88
English: However, patients should be advised that they may experience adverse reactions such as fatigue during treatment with Nevirapine Teva.
Danish: Patienter skal informeres om, at træthed kan optræde som en bivirkning ved Nevirapin Tevabehandlingen.
English: Check with your doctor or pharmacist if you are not sure.
Danish: Spørg lægen eller apoteket, hvis der er noget, du er i tvivl om eller føler dig usikker på.
English: Ketoconazole AUC ↓ 0.28 (0.20
Danish: Ketoconazol AUC ↓ 0,28 (0,20
English: If clinical hepatitis occurs, characterised by anorexia, nausea, vomiting, icterus AND laboratory findings (such as moderate or severe liver function test abnormalities (excluding GGT)), nevirapine must be permanently stopped.
Danish: Hvis klinisk hepatitis opstår, kendetegnet ved anoreksi, kvalme, opkastning, icterus OG laboratoriefund (såsom moderate eller alvorlige abnormaliteter ved leverfunktiontests (ekskl.
English: Tipranavir/ritonavir 500/200 mg BID
Danish: Tipranavir/ritonavir 500/200 mg 2 gange daglig
English: Cross resistance to delavirdine and efavirenz is expected after virologic failure with nevirapine.
Danish: I tilfælde af virologisk svigt ved nevirapinbehandling kan der efterfølgende forventes krydsresistens til delavirdin og efavirenz.
English: It is not recommended to coadminister atazanavir/ritonavir and Nevirapine Teva (see section
Danish: Det anbefales ikke at coadministrere atazanavir/ritonavir og Nevirapin Teva (se pkt.
English: Nevirapine Cmax ↑ 1.20
Danish: Nevirapin Cmax ↑ 1,24
English: Didanosine 100-150 mg BID
Danish: Didanosin 100-150 mg 2 gange daglig
English: Abnormal liver functioning has been reported with the use of Nevirapine Teva.
Danish: Unormal leverfunktion er oplevet med behandling med Nevirapin Teva.
English: Tenofovir plasma levels remain unchanged when co-administered with nevirapine.
Danish: Tenofovir-plasmakoncentrationer forbliver uændretved coadministration med nevirapin.
English: Raltegravir 400 mg BID
Danish: Raltegravir 400 mg 2 gange daglig
English: It is not recommended to coadminister fosamprenavir and Nevirapine Teva if fosamprenavir is not co-administered with ritonavir (see section 4.4).
Danish: Det anbefales ikke at coadministrere fosamprenavir og Nevirapin Teva, hvis fosamprenavir ikke coadministreres sammen med ritonavir (se pkt.
English: If it has been more than 8 hours since the dose was due only take the next dose at the usual time.
Danish: Hvis der er gået mere end 8 timer, skal du springe den glemte dosis over og tage næste dosis til sædvanlig tid.
English: The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.
Danish: Delekærven er der, for at tabletten kan deles, så den er nemmere at sluge; ikke for at kunne dosere to halve tabletter.
English: There is not enough evidence to substantiate that the absence of an increased risk for toxicity seen in pretreated women initiating nevirapine with an undetectable viral load (less than 50 copies/ml of HIV-1 in plasma) and CD4 cell counts above 250 cells/mm3 also applies to pregnant women.
Danish: Der er ikke tilstrækkelig evidens til at fastslå, om den manglende øgede risiko for toksicitet, der ses hos tidligere behandlede kvinder, der starter nevirapinbehandling med en ikke detekterbar viral belastning (hiv-1 i plasma mindre end 50 kopier/ml) og CD4-celletal over 250 celler/mm³, også gælder for gravide, da gravide var ekskluderet i de randomiseret studier, og de var tillige underrepræsenteret i kohorte-studier såvel som i metaanalyser.
English: Nevirapine must be permanently discontinued in any patient experiencing hypersensitivity reaction (characterised by rash with constitutional symptoms, plus visceral involvement, such as hepatitis, eosinophilia, granulocytopenia, and renal dysfunction), see section 4.4.
Danish: Nevirapin bør seponeres permanent hos enhver patient, som udvikler overfølsomhedsreaktioner (kendetegnet ved udslæt med konstitutionelle symptomer samt organpåvirkning, såsom hepatitis, eosinofili, granulocytopeni og nyresvigt), se pkt.
English: Nevirapine Teva 200 mg tablets nevirapine
Danish: Nevirapin Teva 200 mg tabletter nevirapin
English: Patients with CLcr ≥ 20 ml/min do not require a dose adjustment, see section 5.2.
Danish: Ingen dosisjustering til patienter med CLcr ≥ 20 ml/min, se pkt.
English: Nevirapine Teva 200 mg tablets
Danish: Nevirapin Teva 200 mg tabletter
English: A durable response to nevirapine for at least three years was documented in this study, and equivalence within a 10% range was demonstrated between nevirapine 200 mg twice daily and efavirenz with respect to treatment failure.
Danish: Der blev demonstreret ækvivalens inden for 10 % mht. behandlingssvigt mellem ”nevirapin 200 mg 2 gange daglig” og efavirenz.
English: If a patient is already taking St. John‘s Wort check nevirapine and if possible viral levels and stop St John‘s Wort.
Danish: Hvis en patient allerede anvender perikon skal serumniveauet for nevirapin kontrolleres samt, hvis muligt, også virusniveauer.
English: You should stop breast-feeding if you are taking Nevirapine Teva.
Danish: Du skal stoppe amningen, hvis du tager Nevirapin Teva.
English: Zidovudine 100-200 mg TID
Danish: Zidovudin 100-200 mg 3 gange daglig
English: As serious and life threatening hepatotoxicity has been observed in controlled and uncontrolled studies predominantly in patients with a plasma HIV-1 viral load of 50 copies/ml or higher, nevirapine should not be initiated in adult females with CD4 cell counts greater than 250 cells/mm3 or in adult males with CD4 cell counts greater than 400 cells/mm3, who have a detectable plasma HIV-1 RNA unless the benefit outweighs the risk.
Danish: Da alvorlig og livstruende hepatotoksistet i kontrollerede og ukontrollerede studier fortrinsvis er set hos patienter med en hiv-1-virusbelastning i plasma på 50 kopier/ml eller højere, skal nevirapin ikke initieres hos kvinder med CD4-tal større end 250 celler/mm eller hos mænd med CD4-tal større end 400
English: Alternatives to clarithromycin, such as azithromycin should be considered.
Danish: Et alternativ til clarithromycin, såsom azithromycin bør overvejes, da clarithromycins aktive metabolit har en reduceret virkning over for Mycobacteriumaviumintracellulær kompleks.
English: Each tablet contains 200 mg nevirapine (as nevirapine anhydrate).
Danish: En tablet indeholder 200 mg nevirapin (som nevirapinanhydrat).
English: Nevirapine Teva is indicated in combination with other anti-retroviral medicinal products for the treatment of HIV-1 infected adults, adolescents, and children of any age (see section 4.2).
Danish: Nevirapin Teva er indiceret til behandling af hiv-1-smittede patienter (voksne, unge og børn i alle aldre) i kombination med andre antiretrovirale lægemidler (se pkt.
English: Female gender and higher CD4 counts (>250/mm in adult females and >400/mm in adult males) at the initiation of nevirapine therapy are associated with a greater risk of hepatic adverse reactions if the patient has detectable plasma HIV-1 RNA - i.e. a concentration ≥ 50 copies/ml - at the initiation of nevirapine.
Danish: Kvindelige patienter og patienter med høje CD4-tal (>250 celler/mm3 for kvinder og >400 celler/mm3 for mænd) ved initiering af nevirapinbehandling, og som har et detekterbart plasmaniveau af hiv-1-RNA - dvs. ≥50 kopier/ml - har en højere risiko for leverpåvirkninger.
English: If a dose is missed and it is more than 8 hours later, the patient should only take the next dose at the usual time.
Danish: Er der gået mere end 8 timer, skal patienten undlade at tage den glemte dosis og tage næste dosis på det sædvanlige tidspunkt.
English: Fluconazole Cmin ↔ 0.93 (0.86-1.01) Fluconazole Cmax ↔ 0.92 (0.85-0.99)
Danish: Fluconazol Cmin ↔ 0,93 (0,86-1,01) Fluconazol Cmax ↔ 0,92 (0,85-0,99)
English: Rashes occur alone or in the context of drug reaction with eosinophilia and systemic symptoms, characterised by rash with constitutional symptoms such as fever, arthralgia, myalgia and lympadenopathy, plus visceral involvement, such as hepatitis, eosinophilia, granulocytopenia, and renal dysfunction.
Danish: Udslæt opstår selvstændigt eller i sammenhæng med lægemiddelreaktion med eosinofili og systemiske reaktioner, karakteriseret ved udslæt med konstitutionelle symptomer, såsom feber, ledsmerter, muskelsmerter og lymfeknudesvulster sammen organpåvirkning, såsom hepatitis, eosinofili, granulocytopeni og nyredysfunktion.
English: Female gender and higher CD4 counts at the initiation of nevirapine therapy in treatment-naïve patients is associated with increased risk of hepatic adverse reactions.
Danish: Behandlingsnaive kvindelige patienter og behandlingsnaive patienter med høje CD4-celletal ved initiering af behandling med nevirapinhar en højere risiko for leverpåvirkninger.
English: Maintenance packs
Danish: Vedligeholdelsespakning
English: As hepatotoxicity is more frequent in women with CD4 cell counts above 250 cells/mm3 with detectable HIV-1 RNA in plasma (50 or more copies/ml),
Danish: Da hepatotoksicitet er hyppigere hos kvinder med et CD4-celletal over 250 celler/mm³, med detekterbar hiv-1-RNA i plasma (50 kopier/ml eller flere), bør dette forhold tages i betragtning ved beslutning om terapi (se pkt.
English: Cmax ↑ 1.47 (1.21-1.80) Nevirapine AUC ↑ 1.26
Danish: Cmax ↑ 1,47 (1,21-1,80) Nevirapin AUC ↑ 1,26 Nevirapin Cmin ↑ 1,28
English: Hypersensitivity reactions can also occur as rash with other side effects such as: - fever - blistering of your skin - mouth sores - inflammation of the eye - swelling of the face - general swelling - shortness of breath - muscle or joint pain - a reduction in the numbers of your white blood cells (granulocytopenia) - general feelings of illness - severe problems with liver or kidneys (liver or kidney failure).
Danish: - feber - blærer på huden - sår i munden - øjenbetændelse - ansigtshævelse - generel hævelse - åndenød - muskel- eller ledsmerter - nedsat antal hvide blodlegemer (granulocytopeni) - en generel følelse af sygdom - alvorlige problemer med lever eller nyrer (lever- eller nyresvigt).
English: The first 18 weeks of therapy with nevirapine are a critical period which requires close monitoring of patients to disclose the potential appearance of severe and life-threatening skin reactions (including cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)) and serious hepatitis/hepatic failure.
Danish: De første 18 uger af behandlingen med nevirapin er en kritisk periode, som kræver tæt monitorering af patienterne for at afsløre en potentiel udvikling af alvorlige og livstruende hudreaktioner (inkl.
English: Nevirapine Teva tablets can be taken by: - children 16 years of age or older - children under 16 years of age who:
Danish: Nevirapin Teva tabletter kan tages: - af unge på 16 år eller ældre - unge under 16 år, som - vejer 50 kg eller mere - eller har et legemsoverfladeareal på over 1,25 m2.
English: or anaphylactic shock - decreased numbers of red blood cells (anaemia) - yellow skin (jaundice) - severe and life-threatening skin rashes (Stevens-Johnson syndrome/toxic epidermal necrolysis) - hives (urticaria) - fluid under the skin (angioedema) - joint pain (arthralgia) - muscle pain (myalgia) - decreased blood phosphorus - increased blood pressure
Danish: Ikke almindelig (kan forekomme hos op til 1 ud af 100 patienter): - allergisk reaktion karakteriseret ved udslæt, hævelse af ansigt, åndenød (sammensnøring af luftvejene) eller anafylaktisk shock - fald i antallet af røde blodlegemer (anæmi) - gulsot (huden bliver gul) - alvorlige og livstruende hudreaktioner (Stevens-Johnsons syndrom/toksisk epidermal nekrolyse) - nældefeber - væskedannelse under huden (angioødem) - ledsmerter - muskelsmerter (myalgi) - nedsat phosphat i blodet - forhøjet blodtryk
English: TEVA UK Ltd Brampton Road, Hampden Park,
Danish: TEVA UK Ltd Brampton Road, Hampden Park, Eastbourne, East Sussex, BN22 9AG Storbritannien