FrancophonIA/ELRC3.0 huggingface dataset:
English: However, during the period of administration of filgrastim for PBPC mobilisation, filgrastim should be discontinued or its dosage should be reduced if the leukocyte counts rise to > 70 x 109/L.
Croatian: Međutim, tijekom razdoblja primjene filgrastima za mobilizaciju stanica preteča periferne krvi, potrebno je prekinuti primjenu ili smanjiti dozu filgrastima ako se broj leukocita poveća na > 70 x 109/l.
English: Very common: ≥ 1/10
Croatian: Vrlo često: ≥ 1/10
English: A diagnosis of splenic rupture should be considered in donors and/or patients reporting left upper abdominal pain or shoulder tip pain.
Croatian: Dijagnozu rupture slezene potrebno je razmotriti u darivatelja i/ili bolesnika koji navode bol u gornjem lijevom dijelu abdomena ili bol u ramenu.
English: These have generally occurred in patients with advanced malignant diseases, sepsis, taking multiple chemotherapy medications or undergoing apheresis (see section 4.4).
Croatian: Uglavnom su se očitovali u bolesnika s uznapredovalim malignim bolestima, onih sa sepsom, u bolesnika koji su primali više od jednog kemoterapijskog lijeka i u bolesnika na kojima se provodila afereza (vidjeti odjeljak 4.4).
English: This includes any side effects not listed in this leaflet.
Croatian: To uključuje i svaku nuspojavu koja nije navedena u ovo j uputi.
English: Sweets syndrome (acute febrile neutrophili c dermatosis) Cutaneous
Croatian: Sweetsov sindrom (akutna febrilna neutrofilna dermatoza)
English: Accofil and peripheral blood stem cell transplantation (stem cells collected from the blood to use in bone marrow transplantation)
Croatian: Accofil i presađivanje matičnih stanica iz periferne krvi (matične stanice prikupljene iz krvi i korištene u presađivanju koštane srži)
English: Increases in volume, measured radiographically occurred early during filgrastim therapy and tended to plateau later in treatment.
Croatian: Prema radiografskim mjerenjima, volumen bi se povećao u ranoj fazi liječenja filgrastimom, a kasnije je tijekom liječenja ostao podjednak.
English: Patients treated with myeloablative therapy followed by bone marrow transplantation Filgrastim is administered as an intravenous short-term infusion over 30 minutes or as a subcutaneous or intravenous continuous infusion over 24 hours, in each case after dilution in 20 ml of glucose 50 mg/ml (5%) solution.
Croatian: Filgrastim se primjenjuje kao kratkotrajna intravenska infuzija u trajanju od 30 minuta ili kao supkutana ili intravenska kontinuirana infuzija u trajanju od 24 sata, u oba slučaja nakon razrjeđenja u 20 ml otopine glukoze od 50 mg/ml (5%).
English: Infusion of PBPCs accelerates haematopoietic recovery reducing the duration of risk for haemorrhagic complications and the need for platelet transfusions.
Croatian: Infuzija stanica preteča periferne krvi ubrzava oporavak krvotvorne funkcije smanjujući trajanje rizika od hemoragijskih komplikacija i potrebu za transfuzijom trombocita.
English: Data from clinical studies in paediatric patients indicate that the safety and efficacy of filgrastim are similar in both adults and children receiving cytotoxic chemotherapy suggesting no age-related differences in the pharmacokinetics of filgrastim.
Croatian: Podaci iz kliničkih ispitivanja filgrastima u pedijatrijskih bolesnika pokazuju da su sigurnost i djelotvornost filgrastima u djece koja primaju citotoksičnu kemoterapiju slične onima u odraslih, što ukazuje na to da nema razlike u farmakokinetici filgrastima povezane s dobi.
English: Ahmedabad - 382213 Gujarat
Croatian: Sarkhej Bavla Highway Village Moraiya; Taluka: Sanand, Ahmedabad - 382213 Gujarat Indija
English: Special precautions in patients with acute myeloid leukaemia (AML)
Croatian: Posebne mjere opreza u bolesnika s akutnom mijeloičnom leukemijom (AML) Rast zloćudnih stanica
English: In view of the possible risk of microbial contamination, Accofil syringes are for single use only.
Croatian: Zbog moguće mikrobiološke kontaminacije, štrcaljke s lijekom Accofil namijenjene su samo za jednokratnu primjenu.
English: Within each frequency grouping undesirable effects are presented in order of decreasing seriousness.
Croatian: Unutar svake skupine učestalosti, nuspojave su prikazane od najozbiljnijih prema manje ozbiljnima.
English: Accofil is available in packs containing 1, 3, 5, 7 and 10 pre-filled syringes, with or without prefixed needle safety guard and alcohol swabs.
Croatian: Accofil je dostupan u pakiranjima koja sadrže 1, 3, 5, 7 ili 10 napunjenih štrcaljki, sa ili bez ugrađenog sigurnosnog štitnika za iglu i maramicama natopljenim alkoholom.
English: Kidney injury has been seen in patients who received Accofil.
Croatian: Ozljeda bubrega zabilježena je u bolesnika koji su primali Accofil.
English: Each ml of solution contains 96 million units (MU) (equivalent to 960 micrograms [μg]) of filgrastim.
Croatian: Jedan ml otopine sadrži 96 milijuna jedinica (MU) (što odgovara 960 mikrograma [µg]) filgrastima.
English: Type I glass pre-filled syringe with a permanently attached stainless steel needle in the tip and 1/40 printed markings for graduations from 0.1 mL to 1 mL on the barrel.
Croatian: I s neodvojivom iglom od nehrđajućeg čelika na vrhu i gradacijskom skalom s 1/40 otisnutim oznakama od 0,1 ml do 1 ml na tijelu štrcaljke.
English: Transient thrombocytopenia (platelets < 100 x 109/L) following filgrastim administration and leukapheresis was observed in 35% of subjects studied.
Croatian: Prolazna trombocitopenija (trombociti < 100 x 109/l) nakon primjene filgrastima i leukafereze bila je opažena u 35% ispitanika.
English: Following subcutaneous administration of recommended doses , serum concentrations were maintained above 10ng/ml for 8 to 16 hours.
Croatian: Nakon supkutane primjene preporučenih doza, koncentracije u serumu bile su održane iznad 10 ng/ml tijekom 8-16 sati.
English: You will normally receive your first dose of Accofil at least 24 hours after your chemotherapy and at least 24 hours after receiving your bone marrow transplant.
Croatian: Prvu dozu Accofila u pravilu ćete primiti najmanje 24 sata nakon kemoterapije i najmanje 24 sata nakon primanja transplantata koštane srži.
English: 1 pre-filled syringe (0.5 ml) + 1 alcohol swab “3 pre-filled syringe (0.5 ml) + 3 alcohol swabs” “5 pre-filled syringes (0.5 ml) + 5 alcohol swabs” “10 pre-filled syringe (0.5 ml) + 10 alcohol swabs” “7 pre-filled syringe (0.5 ml) + 7 alcohol swabs”
Croatian: 1 napunjena štrcaljka (0,5 ml) + 1 maramica natopljena alkoholom “3 napunjenje štrcaljke (0,5 ml) + 3 maramice natopljene alkoholom” “5 napunjenih štrcaljki (0,5 ml) + 5 maramica natopljenih alkoholom” “10 napunjenih štrcaljki (0,5 ml) + 10 maramica natopljenih alkoholom” “7 napunjenih štrcaljki (0,5 ml) + 7 maramica natopljenih alkoholom”
English: Accofil may have a minor influence on your ability to drive and use machines.
Croatian: Accofil može u manjoj mjeri utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
English: Dose reductions of Filgrastim have been noted to slow or stop the progression of splenic enlargement in patients with severe chronic neutropenia, and in 3% of patients a splenectomy was required.
Croatian: Primijećeno je da smanjenje doze filgrastima usporava ili zaustavlja progresiju povećanja slezene u bolesnika s teškom kroničnom neutropenijom, a u 3 % bolesnika bila je neophodna splenektomija.
English: Based on reported data for another filgrastim product similar to Accofil, comparable findings plus increased fetal malformations were observed at 100 µg/kg/day, a maternally toxic dose which corresponded to a systemic exposure of approximately 50-90 times the exposures observed in patients treated with the clinical dose of 5 µg/kg/day.
Croatian: Na osnovi zabilježenih podataka za drugi lijek s filgrastimom sličan Accofilu, zabilježeni su usporedivi rezultati te, dodatno, povećan broj malformacija fetusa pri 100 µg/kg/dan, što je doza koja je toksična kod majke i koja odgovara sustavnom izlaganju od oko 50-90 puta većem od izloženosti zabilježene u bolesnika koji su liječeni kliničkom dozom od 5 µg/kg/dan.
English: Cases of capillary leak syndrome have been reported in the post marketing setting with granulocyte colony-stimulating factor use.
Croatian: Slučajevi stanja povećane kapilarne propusnosti zabilježeni su nakon stavljanja u promet vezano uz primjenu čimbenika poticanja granulocitnih kolonija.
English: Pseudogout has been reported in cancer patients treated with filgrastim, and the frequency is estimated as uncommon from clinical trial data.
Croatian: U onkoloških bolesnika liječenih filgrastimom zabilježen je pseudogiht, a učestalost se na temelju podataka iz kliničkih ispitivanja procjenjuje kao manje česta.
English: l. After injecting the liquid, remove the needle while keeping the syringe at the same angle and maintaining pressure on the plunger, then let go of your skin.
Croatian: Nakon ubrizgavanja tekućine izvucite iglu držeći štrcaljku pod istim kutom i zadržavajući pritisak na klipu, a zatim pustite nabor kože.
English: ARDS is uncommon in patients with cancer;
Croatian: ARDS je manje čest u bolesnika koji boluju od raka;
English: In order to improve the traceability of granulocyte-colony stimulating factors (G-CSFs), the trade name of the administered product should be clearly recorded in the patient file.
Croatian: Kako bi se moglo pratiti primijenjene čimbenike poticanja rasta granulocitnih kolonija (G CSF), zaštićeni naziv primijenjenog lijeka potrebno je čitko zapisati u medicinsku dokumentaciju bolesnika.
English: Dilution to a final concentration less than 0.2 MU (2 µg) per ml is not recommended at any time.
Croatian: Nikako se ne preporučuje razrijediti do konačne koncentracije manje od 0,2 MU (2 µg) po ml.
English: • think you may be pregnant; or • are planning to have a baby.
Croatian: • ste trudni ili dojite; • mislite da biste mogli biti trudni; ili
English: The most serious adverse reactions that may occur during Filgrastim treatment include: anaphylactic reaction, serious pulmonary adverse events (including interstitial pneumonia and ARDS), capillary leak syndrome, severe splenomegaly/splenic rupture, transformation to myelodysplastic syndrome or leukaemia in SCN patients, GvHD in patients receiving allogeneic bone marrow transfer or peripheral blood cell progenitor cell transplant and sickle cell crisis in patients with sickle cell disease.
Croatian: Najozbiljnije nuspojave koje se mogu javiti prilikom liječenja filgrastimom su: anafilaktička reakcija, ozbiljne plućne nuspojave (uključujući intersticijsku pneumoniju i ARDS), sindrom kapilarnog curenja, teška splenomegalija/ruptura slezene, transformacija u mijelodisplastični sindrom ili leukemiju kod bolesnika s teškom kroničnom neutropenijom (engl. severe chronic neutropenia, SCN), reakcija presatka protiv primatelja (GvHD) kod bolesnika koji primaju alogenu transplantaciju koštane srži ili transplantaciju progenitorskih stanica iz periferne krvi te kriza srpastih stanica kod bolesnika sa bolešću srpastih stanica.
English: The most commonly reported adverse reactions are pyrexia, musculoskeletal pain (which includes bone pain, back pain, arthralgia, myalgia, pain in extremity, musculoskeletal pain, musculoskeletal chest pain, neck pain), anaemia, vomiting, and nausea.
Croatian: Najčešće zabilježene nuspojave su pireksija, mišićno-koštana bol (uključujući bol u kostima, bol u leđima, artralgiju, mialgiju, bol u ekstremitetima, mišićno-koštanu bol, mišićno-koštanu bol u prsištu, bol u vratu), anemija, povraćanje i mučnina.
English: 1 pre-filled syringe (0.5 ml) + 1 alcohol swab “5 pre-filled syringes (0.5 ml) + 5 alcohol swabs” “3 pre-filled syringe (0.5 ml) + 3 alcohol swabs” “10 pre-filled syringe (0.5 ml) + 10 alcohol swabs”
Croatian: 1 napunjena štrcaljka (0,5 ml) + 1 maramica natopljena alkoholom “5 napunjenih štrcaljki (0,5 ml) + 5 maramica natopljenih alkoholom” “3 napunjene štrcaljke (0,5 ml) + 3 maramice natopljene alkoholom” “10 napunjenih štrcaljki (0,5 ml) + 10 maramica natopljenih alkoholom”
English: • swelling and/or fluid in the lungs (pulmonary oedema)
Croatian: • oticanje i/ili tekućina u plućima
English: Do not administer filgrastim to patients with a history of hypersensitivity to filgrastim or pegfilgrastim.
Croatian: Filgrastim se ne smije primjenjivati u bolesnika s preosjetljivošću na filgrastim ili pegfilgrastim u anamnezi.
English: Each pack contains one, three, five, seven or ten pre-filled syringes, with or without a needle safety guard, and alcohol swabs.
Croatian: Jedno pakiranje sadrži jednu, tri, pet, sedam ili deset napunjenih štrcaljki, sa ili bez sigurnosnog štitnika za iglu i maramicu/e natopljenu/e alkoholom.
English: Hypersensitivity-type reactions including anaphylaxis, rash, urticaria, angioedema, dyspnoea and hypotension occurred on initial or subsequent treatment in clinical studies and in post-marketing experience.
Croatian: Reakcije preosjetljivosti uključujući anafilaksiju, osip, urtikariju, angioedem, dispneju i hipotenziju javljale su se na početku i kasnije tijekom liječenja bolesnika koji su primali filgrastim.
English: • If you have any of the following or a combination of the following side effects: swelling or puffiness, which may be associated with passing water less frequently, difficulty breathing, abdominal swelling and feeling of fullness, and a general feeling of tiredness.
Croatian: • Ako imate jednu ili više od sljedećih nuspojava: oticanje ili podbuhlost, možebitno popraćeno rjeđom potrebom za mokrenjem, poteškoće s disanjem, oticanje u području abdomena i osjećaj sitosti uz opći osjećaj umora.
English: Summary of the safety profile
Croatian: Sažetak sigurnosnog profila Accofila
English: There have been reports of GvHD and fatalities in patients receiving G-CSF after allogeneic bone marrow transplantation (see sections 4.4 and 5.1).
Croatian: Zabilježeni su slučajevi GvHD-a i smrtni ishodi u bolesnika koji su primali G-CSF nakon transplantacije alogene koštane srži (vidjeti dio 4.4 i 5.1).
English: f. Find a comfortable, well-lit place and put everything you need where you can reach them (the Accofil pre-filled syringe and alcohol swab).
Croatian: Pronađite udobno, dobro osvijetljeno mjesto i stavite sve što trebate tako da Vam je pri ruci
English: These autologous PBPCs may be harvested and infused after high-dose cytotoxic therapy, either in place of, or in addition to bone marrow transplantation.
Croatian: Ove autologne stanice preteče periferne krvi mogu se prikupiti i dati infuzijom nakon visokih doza citotoksične terapije, bilo umjesto ili kao dodatak presađivanju koštane srži.
English: Proteinuria Urine abnormality Glomerulonephr
Croatian: Poremećaji bubrega i mokraćnog sustava dizurija hematurija proteinurija abnormalno-sti u urinu glomerulonefri tis
English: Pre-filled syringe without needle safety guard b.
Croatian: Napunjena igla bez sigurnosnog štitnika za iglu b.
English: The recommended dose of filgrastim for PBPC mobilisation after myelosuppressive chemotherapy is 0.5 MU (5 µg)/kg/day given daily from the first day after completion of chemotherapy until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range.
Croatian: Preporučena doza filgrastima za mobilizaciju stanica preteča periferne krvi nakon mijelosupresivne kemoterapije iznosi 0,5 MU (5 µg)/kg/dan i daje se svakodnevno od prvog dana nakon završetka kemoterapije do očekivanog najnižeg pada broja neutrofila te njihovog oporavka do normalnog raspona vrijednosti.
English: In order to improve traceability of granulocyte-colony stimulating factors, the product name (Accofil) and batch number of the administered product should be clearly recorded in the patient file Accofil should not be diluted with sodium chloride solution.
Croatian: U cilju poboljšanja praćenja čimbenika poticanja rasta kolonije granulocita, naziv lijeka (Accofil) i broj serije primijenjenog lijeka treba se jasno zabilježiti u pacijentov karton.
English: Reduce to 0.5 MU (5 µg)/kg/day
Croatian: Sniziti na 0,5 MU (5 µg)/kg/dan
English: What Accofil is used for
Croatian: Za što se Accofil koristi
English: Once the neutrophil nadir has been passed, the daily dose of filgrastim should be titrated against the neutrophil response as follows:
Croatian: Nakon prestanka pada broja neutrofila na najnižu vrijednost, dnevnu dozu filgrastima potrebno je prilagoditi odgovoru neutrofila na sljedeći način:
English: The recommended starting dose of filgrastim is 0.1 MU (1 µg )/kg/day given daily with titration up to a maximum of 0.4 MU (4 µg )/kg/day until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 109/L).
Croatian: Preporučena početna doza filgrastima je 0,1 MU (1 µg)/kg/dan primijenjena svakodnevno uz titraciju do najviše 0,4 MU (4 µg)/kg/dan dok se ne postigne normalan broj neutrofila koji je moguće održati (ABN > 2,0 x 109/l).
English: The recommended starting dose of filgrastim is 0.1 MU (1 µg)/kg/day, with titration up to a maximum of 0.4 MU (4 µg)/kg/day until a normal neutrophil count is reached and can be maintained (ANC > 2.0 x 109/L).
Croatian: Preporučena početna doza filgrastima je 0,1 MU (1 µg)/kg/dan uz titraciju do najviše 0,4 MU (4 µg)/kg/dan dok se ne postigne normalan broj neutrofila koji je moguće održati (ABN > 2,0 x 109/l).
English: If you are a patient with severe chronic neutropenia, you may be at risk of developing cancer of the blood (leukaemia, myelodysplastic syndrome (MDS)) You should talk to your doctor about your risks of developing cancers of the blood and what testing should be done.
Croatian: Ako ste bolesnik s teškom kroničnom neutropenijom, možete biti izloženi riziku od pojave raka krvi (leukemije, mijelodisplastičnog sindroma (MDS)).
English: Hypersensitivity, including anaphylactic reactions, occurring on initial or subsequent treatment have been reported in patients treated with filgrastim.
Croatian: Preosjetljivost, uključujući anafilaktičke reakcije, zabilježeni su na početku ili kasnije tijekom liječenja u bolesnika koji su primali filgrastim.
English: In this leaflet
Croatian: Pogledajte dio
English: Special precautions in normal donors undergoing peripheral blood progenitor cell mobilization
Croatian: Posebne mjere opreza u zdravih darivatelja u kojih se provodi mobilizacija stanica preteča periferne krvi
English: Dose reductions were noted to slow or stop the progression of splenic enlargement and in 3% of patients a splenectomy was required.
Croatian: Primijećeno je da sniženje doze usporava ili zaustavlja daljnje povećanje slezene, dok je u 3% bolesnika bilo potrebno napraviti splenektomiju.
English: • decrease of platelets which reduces the ability of blood to clot (thrombocytopenia)
Croatian: • smanjenje broja trombocita što smanjuje sposobnost zgrušavanja krvi (trombocitopenija)
English: Data from clinical studies in paediatric patients indicate that the safety and efficacy of filgrastim are similar in both adults and children receiving cytotoxic chemotherapy.
Croatian: Podaci iz kliničkih ispitivanja u pedijatrijskih bolesnika pokazuju da su sigurnost i djelotvornost filgrastima u djece koja primaju citotoksičnu kemoterapiju slične onima u odraslih.
English: Permanently discontinue filgrastim in patients with clinically significant hypersensitivity.
Croatian: Primjenu filgrastima potrebno je trajno prekinuti u bolesnika s klinički značajnom preosjetljivošću.
English: If you get any side effects, talk to your doctor.
Croatian: Ako osjetite ove simptome, obavijestite svog liječnika.
English: Each pre-filled syringe contains 0.5 ml of solution.
Croatian: Svaka napunjena štrcaljka sadrži 0,5 ml otopine.
English: Analysis includes studies involving BM transplant during this period; some studies used GM-CSF Analysis includes patients receiving BM transplant during this period Use of filgrastim for the mobilisation of PBPCs in normal donors prior to allogeneic PBPC transplantation
Croatian: Analiza uključuje ispitivanja koja su uključivala transplantat koštane srži tijekom tog razdoblja; u nekim se ispitivanjima primjenjivao GM-CSF
English: What you need to know before you use Accofil Do not use Accofil - If you are allergic (hypersensitive) to filgrastim or any of the other ingredients of this medicine (listed in section 6).
Croatian: Ako ste alergični na filgrastim ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
English: In clinical studies, dosing with 30 MU (300 µg)/day on 1 - 7 days per week was required to maintain the ANC > 2.0 x 109/L, with the median dose frequency being 3 days per week.
Croatian: U kliničkim je ispitivanjima bila potrebna primjena doze od 30 MU(300 µg)/dan 1 do 7 dana tjedno kako bi se održao ABN > 2,0 x 109/l, uz medijan učestalosti doziranja od 3 dana tjedno.
English: In clinical studies, dosing with 30 MU (300 µg )/day on 1 - 7 days per week was required to maintain the ANC > 2.0 x 109/L, with the median dose frequency being 3 days per week.
Croatian: U kliničkim je ispitivanjima bila potrebna primjena doze od 30 MU (300 µg)/dan 1 do 7 dana tjedno kako bi se održao ABN > 2,0 x 109/l, uz medijan učestalosti doziranja od 3 dana tjedno.
English: Subsequently, the dose may be individually adjusted every 1-2 weeks to maintain the average neutrophil count between 1.5 x 109/L and 10 x 109/L.A faster schedule of dose escalation may be considered in patients presenting with severe infections.
Croatian: Nakon toga, dozu je kod svakog pojedinog bolesnika moguće prilagođavati svaka 1-2 tjedna kako bi se prosječan broj neutrofila održao na vrijednostima između 1,5 x 109/l i 10 x 109/l.
English: Premature discontinuation of filgrastim therapy, prior to the time of the expected neutrophil nadir, is not recommended.
Croatian: Ne preporučuje se preuranjeni prekid liječenja filgrastimom, prije očekivanog pada broja neutrofila na najnižu vrijednost.
English: Using the pre-filled syringe with a needle safety guard
Croatian: Uporaba napunjene štrcaljke sa sigurnosnim štitnikom za iglu
English: SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF SIGHT AND REACH OF CHILDREN
Croatian: 6. POSEBNO UPOZORENJE O ČUVANJU LIJEKA IZVAN POGLEDA
English: musculoskeletal chest pain, neck pain d Cases were observed in the post-marketing setting with filgrastim in patients undergoing bone marrow transplant or PBPC mobilization e Adverse events with higher incidence in Filgrastim patients compared to placebo and associated with the sequelae of the underlying malignancy or cytotoxic chemotherapy
Croatian: bol u vratu dSlučajevi opaženi nakon stavljanja filgrastima u promet u bolesnika kojima je transplantirana koštana srž ili je rađena mobilizacija stanica preteča koštane srži eNuspojave s povećanom učestalošću kod bolesnika koji su primali filgrastim u usporedbi s placebom te koje su povezane s posljedicama osnovne maligne bolesti ili citotoksične kemoterapije
English: Daily dosing with filgrastim should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range.
Croatian: Svakodnevnu primjenu filgrastima potrebno je nastaviti sve do prestanka očekivanog najnižeg pada broja neutrofila i njihovog porasta do normalnog raspona vrijednosti.
English: How to store Accofil
Croatian: Kako primjenjivati Accofil
English: In the post-marketing setting cutaneous vasculitis has been reported in patients treated with filgrastim.
Croatian: Nakon stavljanja lijeka u promet, zabilježen je kožni vaskulitis u bolesnika liječenih filgrastimom.
English: Depress the plunger slowly and evenly until the entire dose has been given and the plunger cannot be depressed any further.
Croatian: Polako i jednoliko potišćite klip sve dok se ne primijeni cijela doza i dok se klip ne može dalje potisnuti.
English: Using the pre-filled syringe without a needle safety guard
Croatian: Uporaba napunjene štrcaljke bez sigurnosnog štitnika za iglu
English: • worsening of rheumatoid arthritis
Croatian: (Sweetsov sindrom) • pogoršanje reumatoidnog artritisa
English: Bronchitis Upper respiratory tract infection Urinary tract infection
Croatian: Infekcije i infestacije sepsa bronhitis infekcija gornjih dišnih puteva infekcija mokraćnog sustava