FrancophonIA/ELRC3.0 huggingface dataset:
English: Acetylsalicylic acid has been available for over 100 years.
Estonian: El ácido acetilsalicílico se comercializa desde hace más de 100 años.
English: • patients being treated for heart attack with ST-segment elevation, when the doctor thinks that they would benefit from treatment to dissolve blood clots.
Estonian: • pacientes sometidos a tratamiento de un infarto de miocardio con elevación del segmento ST, cuando el médico considera que podrían beneficiarse de un tratamiento para disolver los coágulos.
English: The name of the medicine was changed to Clopidogrel/Acetylsalicylic acid Zentiva on 15 January 2016.
Estonian: El nombre del medicamento se cambió por Clopidogrel/Ácido acetilsalicílico Zentiva el 15 de enero de 2016.
English: Clopidogrel has been authorised since 1998 for reducing platelet aggregation, and is often used in combination with acetylsalicylic acid.
Estonian: El clopidogrel se autorizó en 1998 para reducir la agregación plaquetaria, y a menudo se utiliza en combinación con el ácido acetilsalicílico.
English: Clopidogrel stops the platelets sticking together by blocking a substance called ADP from attaching to a special receptor on their surface.
Estonian: El clopidogrel impide la adhesión entre las plaquetas al bloquear la unión de una sustancia denominada ADP a un receptor especial en su superficie.
English: This stops the platelets becoming ‘sticky', reducing the risk of a blood clot forming.
Estonian: Esto evita que las plaquetas «se peguen», lo que reduce el riesgo de que se formen coágulos de sangre.
English: For more information about treatment with Clopidogrel/Acetylsalicylic acid Zentiva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Estonian: Para mayor información sobre el tratamiento con Clopidogrel/Ácido acetilsalicílico Zentiva, lea el prospecto (también incluido en el EPAR) o consulte a su médico o farmacéutico.
English: Clopidogrel/Acetylsalicylic acid Zentiva must not be used during the last three months of pregnancy.
Estonian: Clopidogrel/Ácido acetilsalicílico Zentiva no debe utilizarse tampoco durante el último trimestre del embarazo.
English: This means that they help to prevent blood cells called platelets from sticking together and forming clots, thus helping to prevent another heart attack.
Estonian: Esto significa que ayudan a impedir que las células sanguíneas denominadas plaquetas se adhieran unas a otras y formen coágulos y, por tanto, ayudan a prevenir un nuevo infarto de miocardio.
English: This reduces the production of a substance called thromboxane, which normally helps clots to form by attaching platelets together.
Estonian: De este modo, se reduce la producción de una sustancia denominada tromboxano, que normalmente contribuye a que las plaquetas se unan, favoreciendo así la formación de coágulos.
English: Because the two active substances have been used together for a number of years, the company presented the results of studies showing that the active substances in Clopidogrel/Acetylsalicylic acid Zentiva are absorbed in the body in the same way when taken in a single tablet as when the two medicines are taken separately.
Estonian: Dado que ambos principios activos se han venido utilizando conjuntamente desde hace años, la empresa presentó los resultados de estudios que demostraban que el organismo absorbe los principios activos de Clopidogrel/Ácido acetilsalicílico Zentiva de la misma forma cuando se toman juntos en un único comprimido que cuando se toman por separado.
English: The combination of the two active substances has an additive effect, reducing the risk of blood clots forming more than either medicine alone.
Estonian: La combinación de los dos principios activos tiene un efecto aditivo y reduce el riesgo de formación de coágulos en mayor medida que cualquiera de los medicamentos por separado.
English: It must not be used in patients who have a disease that is causing bleeding, such as stomach ulcer or bleeding in the brain, or in patients with mastocytosis (high blood levels of certain white blood cells called mast cells).
Estonian: No se debe usar en pacientes que tengan alguna enfermedad que esté causando una hemorragia, como una úlcera de estómago o una hemorragia cerebral, o en pacientes con mastocitosis (niveles altos en sangre de ciertos glóbulos blancos llamados mastocitos).
English: This document is a summary of the European Public Assessment Report (EPAR) for Clopidogrel/Acetylsalicylic acid Zentiva.
Estonian: El presente documento resume el Informe Público Europeo de Evaluación (EPAR) de Clopidogrel/Ácido acetilsalicílico Zentiva.
English: • patients who have unstable angina (a severe type of chest pain) or who have had a heart attack with no ‘ST-segment elevation' (an abnormal reading on the ECG or electrocardiogram), including those who are having a stent (a short tube) inserted into an artery to prevent it from closing up;
Estonian: • pacientes con angina de pecho inestable (un tipo intenso de dolor en el pecho) o que han sufrido un infarto de miocardio sin «elevación del segmento ST» (un signo electrocardiográfico anómalo), incluyendo aquellos a los que se ha implantado una endoprótesis (un tubo corto llamado con frecuencia stent) en una arteria para impedir que se cierre;
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Clopidogrel/Acetylsalicylic acid Zentiva.
Estonian: En él se explica cómo el Comité de Medicamentos de Uso Humano (CHMP) ha evaluado dicho medicamento y emitido un dictamen favorable a la autorización de comercialización y unas recomendaciones sobre las condiciones de su uso.
English: Acetylsalicylic acid stops the platelets sticking together by blocking an enzyme called prostaglandin cyclo-oxygenase.
Estonian: El ácido acetilsalicílico impide la adhesión entre las plaquetas al bloquear una enzima denominada prostaglandina-cicloxigenasa.
English: The most common side effects with Clopidogrel/Acetylsalicylic acid Zentiva (seen in between 1 and 10 patients in 100) are haematoma (a collection of blood under the skin), epistaxis (nosebleeds), gastrointestinal haemorrhage (bleeding in the stomach or gut), diarrhoea, abdominal pain (stomach ache), dyspepsia (heartburn), bruising, and bleeding where the skin is punctured.
Estonian: Los efectos adversos más frecuentes de Clopidogrel/Ácido acetilsalicílico Zentiva (observados en entre 1 y 10 pacientes de cada 100) son hematomas (moraduras, cardenales), epistaxis (hemorragia nasal), hemorragias gastrointestinales (sangrado del estómago o intestino), diarrea, dolor abdominal (de estómago), dispepsia (indigestión), hematomas y hemorragia en la zona de punción de la piel.
English: Clopidogrel/Acetylsalicylic acid Zentiva must not be used in people who are hypersensitive (allergic) to clopidogrel, non steroidal anti-inflammatory drugs (such as acetylsalicylic acid) or any of the other ingredients in Clopidogrel/Acetylsalicylic acid Zentiva.
Estonian: Clopidogrel /Ácido acetilsalicílico Zentiva no se debe utilizar en personas que sean hipersensibles (alérgicas) al clopidogrel, a los antiinflamatorios no esteroideos (como el ácido acetilsalicílico) o a alguno de los componentes del medicamento.
English: For the full list of all side effects reported with Clopidogrel/Acetylsalicylic acid Zentiva, see the package leaflet.
Estonian: Para consultar la lista completa de efectos adversos notificados sobre Clopidogrel/Ácido acetilsalicílico Zentiva, ver el prospecto.
English: Clopidogrel/Acetylsalicylic acid Zentiva is a medicine that contains two active substances, clopidogrel and acetylsalicylic acid (also known as aspirin).
Estonian: Clopidogrel/Ácido acetilsalicílico Zentiva es un medicamento que contiene dos principios activos, clopidogrel y ácido acetilsalicílico (también denominado «aspirina»).
English: Results from the 3 studies in patients with unstable angina or who had had a heart attack showed that the combination of clopidogrel and acetylsalicylic acid taken as separate tablets was more effective at preventing events such as heart attacks than acetylsalicylic acid alone.
Estonian: También presentó los resultados de 3 estudios previos en los que participaron pacientes con angina de pecho inestable o que habían sufrido un infarto de miocardio, que demostraron que la combinación de clopidogrel y ácido acetilsalicílico tomados en comprimidos separados era más eficaz para prevenir episodios como los infartos de miocardio que el ácido acetilsalicílico en monoterapia.
English: The CHMP noted that Clopidogrel/Acetylsalicylic acid Zentiva is comparable to clopidogrel and acetylsalicylic acid tablets taken separately, and concluded that combining both active substances in a single Clopidogrel/Acetylsalicylic acid Zentiva tablet simplifies treatment for patients as they will need to take fewer tablets.
Estonian: El Comité de Medicamentos de Uso Humano (CHMP) señaló que Clopidogrel/Ácido acetilsalicílico Zentiva es equivalente a los comprimidos de clopidogrel y ácido acetilsalicílico tomados por separado, y concluyó que la combinación de ambos principios activos en un único comprimido de Clopidogrel/Ácido acetilsalicílico Zentiva simplifica el tratamiento de los pacientes, ya que tendrán que tomar menos comprimidos.
English: It must not be used in patients who have severely reduced liver or kidney function, or who have a medical condition that includes a combination of asthma, rhinitis (stuffy and runny nose) and nasal polyps (growths in the lining of the nose).
Estonian: Tampoco se debe administrar a pacientes con la función renal o hepática gravemente reducida, o que presenten una enfermedad que consiste en una combinación de asma, rinitis (taponamiento y moqueo nasales) y pólipos nasales (bultos en el revestimiento de las fosas nasales).
English: Both active substances in Clopidogrel/Acetylsalicylic acid Zentiva, clopidogrel and acetylsalicylic acid, are antiplatelet medicines.
Estonian: Los dos principios activos de Clopidogrel/Ácido acetilsalicílico Zentiva, clopidogrel y ácido acetilsalicílico, son antiagregantes plaquetarios.
English: Clopidogrel/Acetylsalicylic acid Zentiva was shown to be comparable to clopidogrel and acetylsalicylic acid taken separately, and can therefore be used in place of the clopidogrel and acetylsalicylic acid tablets that the patients have already been taking.
Estonian: Clopidogrel/Ácido acetilsalicílico Zentiva demostró ser equivalente al clopidogrel y al ácido acetilsalicílico administrados por separado y, por tanto, puede utilizarse en lugar de los comprimidos de clopidogrel y ácido acetilsalicílico que ya estaban tomando los pacientes.
English: What benefit has Clopidogrel/Acetylsalicylic acid Zentiva shown during the studies?
Estonian: ¿Qué beneficio ha demostrado tener Clopidogrel/Ácido acetilsalicílico Zentiva durante los estudios?
English: Clopidogrel/Acetylsalicylic acid Zentiva is taken as one tablet once a day in place of the clopidogrel and acetylsalicylic acid tablets that the patient has already been taking separately.
Estonian: Clopidogrel/Ácido acetilsalicícilo Zentiva se administra en un comprimido una vez al día, en lugar de los comprimidos de clopidogrel y de ácido acetilsalicílico que el paciente esté tomando por separado.
English: What is the risk associated with Clopidogrel/Acetylsalicylic acid Zentiva?
Estonian: ¿Cuál es el riesgo asociado a Clopidogrel/Ácido acetilsalicílico Zentiva?
English: Other information about Clopidogrel/Acetylsalicylic acid Zentiva:
Estonian: Otras informaciones sobre Clopidogrel/Ácido acetilsalicílico Zentiva
English: Why has Clopidogrel/Acetylsalicylic acid Zentiva been approved?
Estonian: ¿Por qué se ha aprobado Clopidogrel/Ácido acetilsalicílico Zentiva?
English: Clopidogrel/Acetylsalicylic acid Zentiva clopidogrel / acetylsalicylic acid
Estonian: Clopidogrel/Ácido acetilsalicílico Zentiva1
English: Clopidogrel/Acetylsalicylic acid Zentiva is used to prevent problems caused by blood clots, such as a heart attack, in adults who are already taking both clopidogrel and acetylsalicylic acid as separate tablets.
Estonian: Se utiliza para prevenir los problemas causados por los coágulos sanguíneos, como el infarto de miocardio, en pacientes adultos que ya estaban tomando comprimidos de clopidogrel y de ácido acetilsalicílico (normalmente conocido como «aspirina») por separado.
English: What is Clopidogrel/Acetylsalicylic acid Zentiva?
Estonian: ¿Qué es Clopidogrel/Ácido acetilsalicílico Zentiva?
English: How does Clopidogrel/Acetylsalicylic acid Zentiva work?
Estonian: ¿Cómo actúa Clopidogrel/Ácido acetilsalicílico Zentiva?
English: How is Clopidogrel/Acetylsalicylic acid Zentiva used?
Estonian: ¿Cómo se usa Clopidogrel/Ácido acetilsalicílico Zentiva?
English: What is Clopidogrel/Acetylsalicylic acid Zentiva used for?
Estonian: ¿Para qué se utiliza Clopidogrel/Ácido acetilsalicílico Zentiva?
English: The full EPAR for Clopidogrel Zentiva can be found on the Agency's: website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
Estonian: Euroopa avaliku hindamisaruande täistekst Clopidogrel Zentiva kohta on ameti veebilehel: website ema.europa.eu/Find medicine/Human medicines/European Public Assessment Reports.
English: This authorisation was based on the authorisation granted to Plavix in 1998 (‘informed consent').
Estonian: Müügiluba põhineb 1998. aastal antud Plavixi müügiloal (teabel põhineva nõusoleku alusel).
English: The European Commission granted a marketing authorisation valid throughout the European Union for Clopidogrel Winthrop on 16 July 2008.
Estonian: Euroopa Komisjon andis Clopidogrel Zentiva müügiloa, mis kehtib kogu Euroopa Liidu territooriumil, 16. juulil 2008.
English: The name of the medicine was changed to Clopidogrel Zentiva on 23 August 2011.
Estonian: Ravimi nimetus muudeti 23. augustil 2011 Clopidogrel Zentivaks.
English: Clopidogrel Zentiva clopidogrel
Estonian: Clopidogrel Zentiva klopidogreel
English: The CHMP decided that Clopidogrel Zentiva's benefits are greater than its risks and recommended that it be given marketing authorisation.
Estonian: Inimravimite komitee otsustas, et Clopidogrel Zentiva kasulikkus on suurem kui sellega kaasnevad riskid, ja soovitas anda ravimi müügiloa.
English: It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Clopidogrel Zentiva.
Estonian: Selles selgitatakse, kuidas inimravimite komitee hindas ravimit ja otsustas toetada müügiloa andmist; samuti esitatakse komitee soovitused, kuidas ravimit kasutada.
English: For more information about treatment with Clopidogrel Zentiva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Estonian: Kui vajate ravimiga Clopidogrel Zentiva toimuva ravi kohta lisateavet, lugege palun pakendi infolehte (mis on samuti Euroopa avaliku hindamisaruande osa) või pöörduge oma arsti või apteekri poole.
English: The standard dose of Clopidogrel Zentiva is one 75-mg tablet once a day.
Estonian: Clopidogrel Zentiva tavaannus on üks 75 mg tablett üks kord ööpäevas.
English: Clopidogrel Zentiva was more effective than aspirin at preventing new ischaemic events.
Estonian: Clopidogrel Zentiva oli uute isheemianähtude ennetamisel aspiriinist efektiivsem.
English: This showed that Clopidogrel Zentiva reduces the risk of an event.
Estonian: See näitas, et Clopidogrel Zentiva vähendab nähtude tekke riski.
English: Clopidogrel Zentiva is converted into its active form in the body.
Estonian: Clopidogrel Zentiva muundub organismis toimeaine aktiivseks vormiks.
English: In acute coronary syndrome and atrial fibrillation, Clopidogrel Zentiva is used together with aspirin, the dose of which should not be higher than 100 mg.
Estonian: Ägeda koronaarsündroomi ja kodade virvenduse korral kasutatakse Clopidogrel Zentivat koos aspiriiniga, mille annus ei tohi ületada 100 mg.
English: Clopidogrel Zentiva is used to prevent problems caused by blood clots in adults who have:
Estonian: Clopidogrel Zentivat kasutatakse trombidest (soonesisestest verehüüvetest) põhjustatud probleemide ennetamiseks täiskasvanutel, kellel on:
English: The most common side effects with Clopidogrel Zentiva (seen in between 1 and 10 patients in 100) are haematoma (a collection of blood under the skin), epistaxis (nosebleeds), gastrointestinal haemorrhage (bleeding in the stomach or gut), diarrhoea, abdominal pain (stomach ache), dyspepsia (heartburn), bruising and bleeding where the skin is punctured.
Estonian: Clopidogrel Zentiva kõige sagedamad kõrvalnähud (esinenud 1-10 patsiendil 100st) on hematoom (verevalum), epistaksis (ninaverejooks), seedekulgla hemorraagia (verejooks maos või sooles), kõhulahtisus, kõhuvalu, düspepsia (kõrvetised) ning verevalumid ja veritsemine süstekohal.
English: Clopidogrel Zentiva should not be used in people who may be hypersensitive (allergic) to clopidogrel or any of the other ingredients.
Estonian: Clopidogrel Zentivat ei tohi kasutada patsiendid, kes võivad olla klopidogreeli või selle ravimi mis tahes muu koostisaine suhtes ülitundlikud (allergilised).
English: The main measure of effectiveness was how many patients experienced a new ‘ischaemic event' (heart attack, ischaemic stroke or death) over one to three years.
Estonian: Efektiivsuse põhinäitaja oli arv, mitmel patsiendil tekkis uus isheemianäht (südameinfarkt, isheemiline insult või surm) 1-3 aasta jooksul.
English: In other words, about 10 patients in 1,000 will avoid having a new ischaemic event two years after starting Clopidogrel Zentiva instead of aspirin.
Estonian: Teisisõnu jääb ligikaudu 10 patsiendil 1000st 2 aasta jooksul pärast seda, kui nad on hakanud võtma aspiriini asemel Clopidogrel Zentivat, uus isheemianäht tekkimata.
English: This is a summary of the European public assessment report (EPAR) for Clopidogrel Zentiva.
Estonian: See on ravimi Clopidogrel Zentiva Euroopa avaliku hindamisaruande kokkuvõte.
English: For genetic reasons, some patients may not be able to convert Clopidogrel Zentiva as effectively as others, which could reduce their response to the medicine.
Estonian: Geneetilistel põhjustel ei suuda kõikide patsientide organism Clopidogrel Zentivat edukalt muundada, mis võib nende ravivastust vähendada.
English: Other information about Clopidogrel Zentiva
Estonian: Muu teave Clopidogrel Zentiva kohta
English: It is used in those patients who have at least one risk factor for vascular
Estonian: Ravimit kasutatakse patsientidel, kellel on vähemalt üks
English: This is then followed by the standard 75-mg dose once a day for at least four weeks (in ‘ST segment elevation' myocardial infarction) or for up to 12 months (in unstable angina or ‘non-Q-wave' myocardial infarction).
Estonian: Seejärel jätkatakse tavalise annusega 75 mg ööpäevas vähemalt 4 nädalat (ST-segmendi elevatsiooniga infarkti korral) või kuni 12 kuud (ebastabiilse stenokardia või Q-sakita südameinfarkti korral).
English: The patients were treated for an average of three years, and the main measure of effectiveness was the number of patients who experienced an ‘event' such as a heart attack, ischaemic stroke or death.
Estonian: Patsiente raviti keskmiselt 3 aastat ja efektiivsuse põhinäitaja oli nende patsientide arv, kellel tekkis näht, näiteks südameinfarkt, isheemiline insult või surm.
English: In the study in atrial fibrillation patients, Clopidogrel Zentiva taken together with aspirin reduced the risk of new events by 11% compared with placebo taken with aspirin, with the largest reduction (28%) seen for stroke.
Estonian: Kodade virvendusega patsientidel toimunud uuringus võrrelduna koos aspiriiniga manustatud platseeboga vähendas koos aspiriiniga võetud Clopidogrel Zentiva uute haigusnähtude riski 11%, kusjuures kõige rohkem vähenes insuldi risk (28%).
English: Previously known as Clopidogrel Winthrop events such as a heart attack or stroke, cannot take vitamin K antagonists (other medicines that prevent blood clots) and are at low risk of bleeding.
Estonian: vaskulaarhäirete, näiteks südameinfarkti või insuldi riskitegur, kes ei saa võtta K-vitamiini antagoniste (vere hüübimist pärssivad ravimid) ja kellel on väiksem verejooksu risk.
English: Clopidogrel Zentiva has been compared with aspirin in a study called CAPRIE including around 19,000 patients who had recently had a heart attack or ischaemic stroke, or who had established peripheral arterial disease.
Estonian: Clopidogrel Zentivat võrreldi aspiriiniga uuringus (CAPRIE), milles osales ligikaudu 19 000 patsienti, kellel oli hiljuti olnud südameinfarkt või isheemiline insult või väljakujunenud perifeersete arterite haigus.
English: In ST segment elevation myocardial infarction, fewer patients on Clopidogrel Zentiva had events than patients on placebo (262 against 377 in the CLARITY study, and 2,121 against 2,310 in the COMMIT study).
Estonian: ST-segmendi elevatsiooniga müokardiinfarkti korral esines Clopidogrel Zentiva manustanud patsientide hulgas vähem nähte kui platseebot saanute seas (uuringus CLARITY 262 patsiendil 377st ning uuringus COMMIT 2121 patsiendil 2310st).
English: Clopidogrel Zentiva has also been compared with placebo in two studies involving patients with ST segment elevation: CLARITY, which involved over 3,000 patients and lasted for up to eight days; and COMMIT, which involved almost 46,000 patients and in which the patients received Clopidogrel Zentiva with or without metoprolol (another medicine used for heart problems or high blood pressure) for up to four weeks.
Estonian: Clopidogrel Zentivat võrreldi platseeboga järgmises kahes uuringus, milles osalesid ST-segmendi elevatsiooniga patsiendid: CLARITY, milles osales üle 3000 patsiendi ja mis kestis kuni 8 päeva, ning COMMIT, milles osales ligi 46 000 patsienti ja milles patsiendid manustasid kuni 4 nädala vältel Clopidogrel Zentivat koos metoprolooliga (samuti südameprobleemide või kõrge vererõhu ravim) või ilma.
English: Some of these patients have had a stent inserted (a short tube) placed in an artery to prevent it from closing up.
Estonian: Mõnedele nendele patsientidele on paigaldatud stent (ahenenud arterit avardav väike toru).
English: In atrial fibrillation, Clopidogrel Zentiva has been compared with placebo (both taken together with aspirin) in one main study involving around 7,500 patients who had at least one risk factor for vascular events and who could not take vitamin K antagonist therapy.
Estonian: Kodade virvenduse korral võrreldi Clopidogrel Zentivat platseeboga (mõlemat manustatuna koos aspiriiniga) ühes põhiuuringus, milles osales ligikaudu 7500 vaskulaarhäirete vähemalt ühe riskiteguriga patsienti, keda ei saa ravida K-vitamiini antagonistiga.
English: Clopidogrel Zentiva is a medicine that contains the active substance clopidogrel.
Estonian: Clopidogrel Zentiva on ravim, mille toimeaine on klopidogreel.
English: In CAPRIE, there were 939 events in the Clopidogrel Zentiva group, and 1,020 in the aspirin group.
Estonian: Uuringus CAPRIE tekkis Clopidogrel Zentivaga ravitute rühmas 939 isheemianähtu ja aspiriinirühmas 1020, mis näitab Clopidogrel Zentiva korral riski suhtelist vähenemist 9% võrrelduna aspiriiniga.
English: This means that fewer patients will have new ischaemic events if they receive Clopidogrel Zentiva than if they receive aspirin.
Estonian: See tähendab, et Clopidogrel Zentiva kasutamisel tekib uusi isheemianähte väiksemal arvul patsientidel kui aspiriini kasutamisel.
English: In acute coronary syndrome, Clopidogrel Zentiva has been compared with placebo (a dummy treatment) in one study involving over 12,000 patients with non-ST segment elevation, 2,172 of whom had a stent inserted during the study (CURE study, lasting up to a year).
Estonian: Ägeda koronaarsündroomi uuringus võrreldi Clopidogrel Zentivat platseeboga (näiv ravim) uuringus, milles osales üle 12 000 ST-segmendi elevatsioonita patsiendi, kellest 2172 patsiendile sisestati uuringu ajal stent (uuring CURE, kestis kuni aasta).