FrancophonIA/ELRC3.0 huggingface dataset:
English: This is a retrospective multicentre study comparing the 3-year antiviral efficacy of nevirapine and efavirenz in combination with stavudine and lamivudine in 2NN patients from week 49 to week 144.
Slovenian: To je retrospektivna multicentrična študija, v kateri primerjajo 3-letno protiretrovirusno učinkovitost nevirapina in efavirenza v kombinaciji s stavudinom in lamivudinom pri bolnikih iz študije 2NN, in sicer od 49. do 144. tedna.
English: Furthermore, in the case nevirapine is used as single dose to prevent vertical transmission of HIV-1 infection, the risk of hepatotoxicity in mother and child cannot be excluded.
Slovenian: Poleg tega pri uporabi nevirapina v enkratnem odmerku za preprečitev vertikalnega prenosa okužbe s HIV-1 ne moremo izključiti tveganja hepatotoksičnih učinkov pri materi in otroku.
English: Nevirapine Teva tablets contain lactose (milk sugar).
Slovenian: Zdravilo Nevirapin Teva tablete vsebuje laktozo (mlečni sladkor).
English: All the randomised studies addressing this issue specifically excluded pregnant women, and pregnant women were under-represented in cohort studies as well as in meta-analyses.
Slovenian: vseh raziskavah z naključno izbiro preizkušank, v katerih so proučevali prav ta pojav, so nosečnice izključili, poleg tega je bilo število nosečnic premajhno tudi v kohortnih raziskavah in pri metaanalizah
English: This study demonstrated a significant reduction in transmission using single dose nevirapine (13.1 % (n = 310) in the nevirapine group, versus 25.1 % (n = 308) in the ultra-short zidovudine group (p = 0.00063)).
Slovenian: V njej se je ta prenos pomembno zmanjšal po uporabi enkratnega odmerka nevirapina (13,1 % (n = 310) v skupini, ki je prejemala nevirapin, v primerjavi s 25,1 % (n = 308) v skupini z ultrakratkim režimom zidovudina (p = 0,00063)).
English: A reduction in white blood cells (granulocytopenia) can occur, which is more common in children.
Slovenian: Zmanjša se lahko število belih krvničk (granulocitopenija), ki je pri otrocih pogostnejša.
English: After 14 days, the recommended dose is one 200 mg tablet twice a day.
Slovenian: Po 14 dneh je priporočeni odmerek ena tableta po 200 mg 2-krat na dan.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections, and Pneumocystis jirovecii pneumonia.
Slovenian: Ustrezni primeri so citomegalovirusni retinitis, generalizirane in/ali žariščne okužbe z mikobakterijami in s Pneumocystis jiroveci povzročena pljučnica.
English: In a panel of 2,923 predominantly subtype B HIV-1 clinical isolates, the mean EC50 value was 90 nM.
Slovenian: Pri naboru 2923 kliničnih izolatov HIV-1, pretežno podtipa B, je bila srednja vrednost EC50 90 nM.
English: (n = 6) were 45 % (± 5 %) of the concentrations in plasma; this ratio is approximately equal to the fraction not bound to plasma protein.
Slovenian: V cerebrospinalni tekočini pri človeku (n = 6) so bile nevirapinove koncentracije 45 % (± 5 %) glede na plazemske; to razmerje je približno enako frakciji, ki se ne veže na beljakovine v plazmi.
English: Numerous studies have been performed examining the use of nevirapine in regards to perinatal transmission, most notably HIVNET 012.
Slovenian: O uporabi nevirapina v povezavi s perinatalnim prenosom so izvedli številne raziskave, med katerimi je zlasti pomembna HIVNET 012.
English: These reactions occur mainly in the first 18 weeks of treatment with Nevirapine Teva.
Slovenian: Pojavijo se pretežno v času prvih 18 tednov zdravljenja z zdravilom Nevirapin Teva.
English: Because of the risk of increased exposure to Nevirapine Teva, caution should be exercised if the medicinal products are given concomitantly and patients should be monitored closely.
Slovenian: Zaradi nevarnosti povečane izpostavljenosti zdravilu Nevirapin Teva je potrebna pri sočasnem dajanju teh zdravil previdnost, bolnike pa je treba skrbno spremljati.
English: There is at present little information on the effects of Nevirapine Teva overdose.
Slovenian: Do sedaj je malo podatkov o učinkih prevelikega odmerka zdravila Nevirapin Teva.
English: Genotypic analysis showed mutations in the HIV-1 RT gene Y181C and/or V106A depending upon the virus strain and cell line employed.
Slovenian: Genotipska analiza je pokazala mutacije genov Y181C in/ali V106A pri RT virusa HIV-1 ,
English: Female patients showed a 13.8 % lower clearance of nevirapine than did male patients.
Slovenian: Pri ženskah je bil nevirapinov očistek za 13,8 % nižji kot pri moških.
English: One side is debossed with "N", a scoreline and "200".
Slovenian: Na eni strani tablete je vtisnjen znak »N«, zareza in znak »200«.
English: In clinical studies, nevirapine has been associated with an increase in HDL- cholesterol and an overall improvement in the total to HDL-cholesterol ratio.
Slovenian: V kliničnih študijah so nevirapin povezovali s povečanjem HDL holesterola in splošnim izboljšanjem razmerja med skupnim holesterolom in HDL holesterolom.
English: The tablets shall be taken with liquid, and should not be crushed or chewed.
Slovenian: Način uporabe Tablete je treba jemati s tekočino, ne sme se jih drobiti ali žvečiti.
English: For children, increase of the dose of lopinavir/ritonavir to 300/75 mg/m2 twice daily with food should be considered when used in combination with Nevirapine Teva, particularly for patients in whom reduced susceptibility to lopinavir/ritonavir is suspected.
Slovenian: Pri otrocih je potrebno presoditi o povečanju odmerjanja kombinacije lopinavir/ritonavir do 300/75 mg/m2 2-krat na dan ob jedi, kadar jo uporabljamo v kombinaciji z zdravilom Nevirapin Teva, zlasti pri bolnikih, pri katerih sumimo na zmanjšano občutljivost za kombinacijo lopinavirja in ritonavirja.
English: ANTI-INFECTIVES Antiretrovirals
Slovenian: ANTIINFEKTIVI Protiretrovirusna zdravila
English: Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practice.
Slovenian: Bolniki z obstoječo motnjo jetrne funkcije, tudi kroničnim aktivnim hepatitisom, imajo med kombiniranim protivirusnim zdravljenjem pogosteje moteno jetrno delovanje, zato jih je potrebno spremljati v skladu s standardno prakso.
English: Based on clinical study experience of 361 paediatric patients the majority of which received combination treatment with ZDV or/and ddI, the most frequently reported adverse events related to nevirapine were similar to those observed in adults.
Slovenian: Na podlagi izkušenj iz kliničnih študij, v katera je bilo vključenih 361 otrok, od katerih je večina prejemala kombinirano zdravljenje z ZDV ali/in ddI, so bili najpogostnejši z nevirapinom povezani neželeni dogodki podobni kot pri odraslih.
English: Nevirapine Teva tablets are supplied in blisters, with 14 (Calendar Pack), 60 or 120 tablets per carton.
Slovenian: Tablete Nevirapin Teva so na voljo v pretisnih omotih po 14 (koledarsko pakiranje), 60 ali 120 tablet v škatli.
English: As Nevirapine Teva must always be taken together with other HIV antiretroviral medicines, you should follow the instructions for your other medicines carefully.
Slovenian: Ker je treba zdravilo Nevirapin Teva vedno jemati skupaj z drugimi protiretrovirusnimi zdravili proti HIV, morate upoštevati tudi navodila za druga zdravila.
English: Gender and older people
Slovenian: Spol in starejši bolniki
English: Nevirapine Teva with food and drink
Slovenian: Zdravilo Nevirapin Teva s hrano in pijačo
English: As mentioned in ‘Warnings and precautions ', above, the most important side effects of Nevirapine Teva are severe and life threatening skin reactions and serious liver damage.
Slovenian: Kot je navedeno v »Opozorila in previdnostni ukrepi«, so najpomembnejši neželeni učinki zdravila Nevirapin Teva hude in življenjsko nevarne kožne reakcije in resne okvare jeter.
English: The simultaneous use of nevirapine (400 mg) plus efavirenz (800 mg) was associated with the highest frequency of clinical adverse events and with the highest rate of treatment failure (53.1%).
Slovenian: Pri sočasni uporabi nevirapina (400 mg) in efavirenza (800 mg) je bila pogostnost kliničnih neželenih učinkov največja, največji pa je bil tudi odstotek neuspešnega zdravljenja (53,1 %).
English: Pharmacotherapeutic group: Antivirals for systemic use, non-nucleoside reverse transcriptase inhibitors, ATC code J05AG01.
Slovenian: Farmakoterapevtska skupina: protivirusna zdravila za sistemsko zdravljenje, (nenukleozidni zaviralci reverzne transkriptaze), oznaka ATC J05AG01.
English: In an open-label clinical study (ACTG 180) granulocytopenia assessed as medicinal product-related occurred in 5/37 (13.5 %) of patients.
Slovenian: V odprti klinični študiji (ACTG 180) se je granulocitopenija, ki je bila po oceni raziskovalcev povezana z zdravilom, pojavila pri 5/37 (13,5 %) bolnikov.
English: Depotmedroxyprogesterone acetate (DMPA) 150 mg every 3 months
Slovenian: Depo medroksiprogesteron acetat (DMPA), 150 mg vsake 3 mesece
English: Only take Nevirapine Teva tablets by mouth.
Slovenian: Zdravilo Nevirapin Teva tablete smete jemati samo skozi usta.
English: Nevirapine Teva 200 mg tablets, following the dosing schedule described above, are suitable for larger children, particularly adolescents, below the age of 16 who weigh more than 50 kg or whose body surface area is above 1.25 m2 according to the Mosteller formula.
Slovenian: Zdravilo Nevirapin Teva 200 mg tablete je po zgoraj opisani shemi odmerjanja primerne za večje otroke, zlasti mladostnike, ki so mlajši od 16 let in težki več kot 50 kg ali katerih telesna površina presega 1,25 m2 po Mostellerjevi formuli.
English: As explained in ”Warnings and precautions”, above, your doctor will monitor you with liver tests or for undesirable effects such as rash.
Slovenian: Kot je opisano v poglavju »Opozorila in previdnostni ukrepi«, bo zdravnik vaše stanje spremljal s preiskavami delovanja jeter in da bi odkril neželene učinke, kot je izpuščaj.
English: Lactose: Nevirapine Teva tablets contain 336 mg of lactose per maximum recommended daily dose.
Slovenian: Laktoza: Zdravilo Nevirapin Teva tablete vsebuje 336 mg laktoze, kar je največji priporočeni dnevni odmerek.
English: Patients with hepatic impairment should be monitored carefully for evidence of medicinal product induced toxicity.
Slovenian: Bolnike z jetrno okvaro je potrebno skrbno spremljati, da bi odkrili znake toksičnosti zdravila.
English: Discuss with your doctor the precautions needed to avoid infecting other people.
Slovenian: potrebnih za preprečitev okužbe drugih ljudi.
English: Elvitegravir/ cobicistat
Slovenian: Elvitegravir/kobicistat
English: The majority of rashes associated with nevirapine occur within the first 6 weeks of initiation of therapy.
Slovenian: Večina izpuščajev, ki so povezani z uporabo nevirapina, se pojavijo v prvih 6 tednih po začetku zdravljenja.
English: CONTRACEPTIVES
Slovenian: KONTRACEPTIVI
English: Patients should be instructed that dose escalation is not to occur if any rash occurs during the two-week lead-in dosing period, until the rash resolves.
Slovenian: Bolnikom je potrebno povedati, da se odmerka ne sme povečati, če se med dvotedenskim uvajalnim obdobjem pojavi kakršenkoli izpuščaj, vse dokler le-ta ne mine.
English: If you are taking or are prescribed rifampicin to treat tuberculosis please inform your doctor before taking this medicine with Nevirapine Teva.
Slovenian: Če jemljete ali so vam predpisali rifampicin za zdravljenje tuberkuloze, obvestite svojega zdravnika preden boste to zdravilo vzeli skupaj z zdravilom Nevirapin Teva.
English: Very common (may affect more than 1 in 10 people): - rash
Slovenian: Zelo pogosti (pojavijo se lahko pri več kot 1 od 10 bolnikov): - izpuščaj;
English: Patients should be instructed to seek medical attention promptly if these occur.
Slovenian: Bolnikom je potrebno naročiti, da morajo ob njihovem pojavu nemudoma poiskati zdravniško pomoč.
English: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Slovenian: Pri nekaterih bolnikih, ki jemljejo kombinirano protiretrovirusno zdravljenje, se lahko razvije kostna bolezen, ki jo imenujemo osteonekroza (odmiranje kostnega tkiva, ki je posledica neprekrvavljenosti kosti).
English: Inform your doctor about all other medicines you are taking before you start taking Nevirapine Teva.
Slovenian: Zdravnika obvestite o vseh zdravilih, ki jih jemljete, preden boste začeli jemati zdravilo Nevirapin Teva.
English: At 12 months, the Kaplan-Meier estimates of the likelihood of reaching the endpoint were 10 % in the nevirapine group, 6 % in the efavirenz group, and 13 percent in the abacavir group (P=0.10 according to an intention-to-treat analysis).
Slovenian: Po 12 mesecih so bile Kaplan-Meierjeve ocene verjetnosti za doseganje opazovanega dogodka 10 % v skupini z nevirapinom, 6 % v skupini z efavirenzem in 14 % v skupini z abakavirjem (P = 0,10 po podatkih iz analize vseh vključenih bolnikov (ITT - intention to treat).
English: Patients who interrupt nevirapine dosing for more than 7 days should restart the recommended dosing regimen using the two week lead-in period.
Slovenian: Bolniki, ki prekinejo jemanje nevirapina za več kot 7 dni, ga morajo začeti ponovno jemati po priporočeni shemi odmerjanja in upoštevati dvotedensko uvajalno obdobje.
English: Abnormal liver function tests have been reported with nevirapine, some in the first few weeks of therapy.
Slovenian: Pri nevirapinu so poročali o nenormalnih izvidih preiskav jetrne funkcije, o nekaterih v prvih tednih zdravljenja.
English: The recommended dose of Nevirapine Teva is one 200 mg tablet daily for the first 14 days (this leadin period should be used because it has been found to lessen the frequency of rash), followed by one 200 mg tablet twice daily, in combination with at least two additional antiretroviral agents.
Slovenian: Priporočeni odmerek zdravila Nevirapin Teva je ena tableta po 200 mg na dan prvih 14 dni (tako uvajalno obdobje je potrebno upoštevati, ker so ugotovili, da zmanjša pogostnost izpuščaja), nato sledi jemanje ene tablete po 200 mg 2-krat na dan, v kombinaciji z najmanj dvema dodatnima protivirusnima zdraviloma.
English: All of these effects subsided following discontinuation of nevirapine.
Slovenian: Vsi našteti učinki so po ukinitvi uporabe nevirapina minili.
English: Of the patients with grade 3 or 4 liver-associated laboratory toxicity, the proportions coinfected with hepatitis B or hepatitis C virus were 6.7% and 20.0% in the nevirapine twice daily group, 5.6% and 11.1% in the efavirenz group.
Slovenian: Med bolniki, ki so imeli z jetri povezan laboratorijski toksični učinek 3. ali 4. stopnje, je bil delež bolnikov s sočasno okužbo z virusom hepatitisa B ali hepatitisa C 6,7 % oziroma 20,0 % v skupini, ki je jemala dvakrat na dan nevirapin, in 5,6 % oziroma 11,1 % v skupini, ki je jemala efavirenz.
English: Nevirapine Teva administration above the recommended dose might increase the frequency and seriousness of skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis.
Slovenian: Dajanje odmerkov zdravila Nevirapin Teva, večjih od priporočenih, lahko poveča pogostnost in resnost kožnih reakcij, kot sta Stevens-Johnsonov sindrom in toksična epidermalna nekroliza.
English: The overall incidence of adverse events was significantly lower (61 patients, or 41%) in the abacavir group than in the nevirapine group (83 patients, or 54%) or the efavirenz group (89 patients, or 57%).
Slovenian: Skupna pogostnost neželenih učinkov je bila značilno manjša pri skupini z abakavirjem (61 bolnikov ali 41 %) kot pri skupini z nevirapinom (83 bolnikov ali 54 %) ali efavirenzem (89 bolnikov ali 57 %).
English: Carefully read the package leaflet of all other HIV medicinal products you are taking in combination with Nevirapine Teva.
Slovenian: Natančno preberite navodila za uporabo vseh drugih zdravil, ki jih boste jemali zaradi okužbe s HIV v kombinaciji z zdravilom Nevirapin Teva.
English: Concomitant prednisone use (40 mg/day for the first 14 days of nevirapine administration) has been shown not to decrease the incidence of nevirapine-associated rash, and may be associated with an increase in incidence and severity of rash during the first 6 weeks of nevirapine therapy.
Slovenian: Pokazalo se je, da sočasna uporaba prednizona (40 mg/dan prvih 14 dni zdravljenja z nevirapinom) ne zmanjša pogostnosti izpuščaja, ki ga povzroča nevirapin; morda pa je povezana s povečano pogostnostjo in resnostjo izpuščaja prvih 6 tednov zdravljenja z nevirapinom.
English: Median age was 34 years and about 64% were male patients, median CD4 cell count was 170 and 190 cells per mm3 in the nevirapine twice daily and efavirenz groups, respectively.
Slovenian: Srednja starost je bila 34 let, približno 64 % bolnikov je bilo moških, srednje število celic CD4 je bilo 170 celic na mm3 v skupini, ki je dvakrat na dan prejemala nevirapin, in 190 celic na mm3 v skupini, ki je prejemala efavirenz.
English: Do not take Nevirapine Teva after an exposure to HIV unless you have been diagnosed with HIV and instructed to do so by your doctor.
Slovenian: Ne vzemite zdravila Nevirapin Teva, če ste bili izpostavljeni HIV, oziroma ga vzemite samo, če so vam postavili diagnozo okužbe s HIV in vam je tako naročil vaš zdravnik.
English: Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Slovenian: Bolnikom je potrebno svetovati, naj poiščejo zdravniško pomoč, če se pri njih pojavijo bolečine v sklepih, togost sklepov ali težave z gibljivostjo.
English: Women appear to be at higher risk than men of developing rash, whether receiving nevirapine or non- nevirapine containing therapy.
Slovenian: Zdi se, da je tveganje pojava izpuščaja pri ženskah večje kot pri moških ne glede na to, ali poteka zdravljenje, ki vključuje nevirapin, ali takšno, ki ga ne vsebuje.
English: If you are taking oral contraceptives (e.g. “pill“) or other hormonal methods of birth control during treatment with Nevirapine Teva you should use a barrier contraception (e.g. condoms) in addition to prevent pregnancy and further HIV transmission.
Slovenian: Če med zdravljenjem z zdravilom Nevirapin Teva uporabljate oralne kontraceptive (npr. "tabletko") ali druge hormonske metode za preprečevanje zanositve, bi morali dodatno uporabljati mehansko kontracepcijo (npr. kondom) za preprečevanje zanositve in nadaljnjega prenašanja HIV.
English: What Nevirapine Teva is and what it is used for
Slovenian: Kaj je zdravilo Nevirapin Teva in za kaj ga uporabljamo
English: Most of the experience with nevirapine is in combination with nucleoside reverse transcriptase inhibitors (NRTIs).
Slovenian: Večina izkušenj z nevirapinom izvira iz kombiniranega dajanja z nukleozidnimi zaviralci reverzne transkriptaze (NRTI).
English: White opaque PVC/PE/PVdC - Aluminium blisters or OPA/Alu/PVC - Aluminium blisters.
Slovenian: Beli neprosojni aluminijasti pretisni omoti iz PVC/PE/PVdC ali OPA/Alu/PVC aluminijasti pretisni omoti.
English: You must take Nevirapine Teva together with other antiretroviral medicines.
Slovenian: Zdravilo Nevirapin Teva morate jemati hkrati z drugimi protiretrovirusnimi zdravili.
English: Patients with rare hereditary problems of galactose intolerance e.g. galactosaemia, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Slovenian: Bolniki z redkim, dednim neprenašanjem galaktoze, na primer galaktozemijo, s pomanjkanjem laktaze Lapp ali z malabsorpcijo glukoze-galaktoze, zdravila ne smejo jemati.
English: - St John's Wort (Hypericum perforatum, medicine to treat depression) - rifampicin (medicine to treat tuberculosis) - rifabutin (medicine to treat tuberculosis) - macrolides e.g. clarithromycin (medicine to treat bacterial infections) - fluconazole (medicine to treat fungal infections) - ketoconazole (medicine to treat fungal infections) - itraconazole (medicine to treat fungal infections) - methadone (medicine used for treatment of opiate addicts) - warfarin (medicine to reduce blood clotting) - hormonal contraceptives (e.g. the “pill”) - atazanavir (another medicine to treat HIV-infection) - lopinavir/ritonavir (another medicine to treat HIV-infection) - fosamprenavir (another medicine to treat HIV-infection) - efavirenz (another medicine to treat HIV-infection) - etravirine (another medicine to treat HIV-infection) - rilpivirine (another medicine to treat HIV-infection) - delavirdine (another medicine to treat HIV-infection) - zidovudine (another medicine to treat HIV-infection) - boceprevir (medicine to treat hepatitis C) - telaprevir (medicine to treat hepatitis C) - elvitegravir/cobicistat (another medicine to treat HIV-infection)
Slovenian: - metadon (zdravilo za zdravljenje odvisnikov od opiatov), - varfarin (zdravilo za zmanjšanje nastajanja krvnih strdkov), - hormonske kontraceptive (npr. »tabletke«), - atazanavir (drugo zdravilo za zdravljenje okužbe s HIV), - lopinavir/ritonavir (drugo zdravilo za zdravljenje okužbe s HIV), - fosamprenavir (drugo zdravilo za zdravljenje okužbe s HIV), - efavirenz (drugo zdravilo za zdravljenje okužbe s HIV), - etravirin (drugo zdravilo za zdravljenje okužbe s HIV), - rilpivirin (drugo zdravilo za zdravljenje okužbe s HIV), - delavirdin (drugo zdravilo za zdravljenje okužbe s HIV), - zidovudin (drugo zdravilo za zdravljenje okužbe s HIV), - boceprevir (zdravilo za zdravljenje hepatitisa C) - telaprevir (zdravilo za zdravljenje hepatitisa C) - elvitegravir/kobicistat (drugo zdravilo za zdravljenje okužbe s HIV);
English: Nevirapine: Co-administration of ritonavir does not lead to any clinically relevant change in nevirapine plasma levels.
Slovenian: Navirapin: Sočasno dajanje ritonavirja ne povzroči nikakršne klinično pomembne spremembe ravni nevirapina v plazmi.
English: NET Cmin ND
Slovenian: Cmin NET ND
English: The safety and efficacy of nevirapine has not been established in patients with significant underlying liver disorders.
Slovenian: Varnost in učinkovitost nevirapina še nista raziskani pri bolnikih s hujšimi jetrnimi motnjami.
English: Absolute bioavailability in 12 healthy adults following single-dose administration was 93 ± 9% (mean SD) for a 50 mg tablet and 91 ± 8 % for an oral solution.
Slovenian: Absolutna biološka uporabnost je bila pri 12 zdravih odraslih po enkratnem odmerku 93 ± 9 % (srednja SD) pri 50 mg tableti in 91 ± 8 % pri peroralni raztopini.
English: In study 1100.1090, from which the majority of related adverse events (n=28) were received, patients on placebo had a higher incidence of events of granulocytopenia (3.3%) than patients on nevirapine
Slovenian: V študiji 1100.1090, iz katere izvira večina podatkov o povezanih neželenih dogodkih (n=28), je bila pojavnost granulocitopenije večja pri bolnikih, ki so prejemali placebo (3,3 %), kot pri bolnikih,
English: The primary endpoint, treatment failure, was defined as less than 1 log10 decline in plasma HIV-1 RNA in the first 12 weeks, or two consecutive measurements of more than 50 copies/ ml from week 24 onwards, or disease progression.
Slovenian: Primarni opazovani dogodek, to je neuspešnost zdravljenja, je bil opredeljen kot manjši upad plazemske koncentracije HIV-1 RNA od 1 log10 prvih 12 tednov ali dve zaporedni izmerjeni vrednosti več kot 50 kopij/ ml po 24. tednu ali napredovanje bolezni.
English: Nevirapine is a non-competitive inhibitor of the HIV-1 reverse transcriptase, but it does not have a biologically significant inhibitory effect on the HIV-2 reverse transcriptase or on eukaryotic DNA polymerases α, β, γ, or δ.
Slovenian: Nevirapin je nekompetitiven zaviralec reverzne transkriptaze HIV-1, nima pa biološko pomembnega zaviralnega učinka na reverzno trankriptazo HIV-2 ali evkariotske DNA-polimeraze α, β, γ in δ. Protivirusno delovanje in vitro
English: However the risk continues past this period and monitoring should continue at frequent intervals throughout treatment.
Slovenian: Vendar pa je tveganje prisotno tudi po tem obdobju, zato je potrebno zdravljenje ves čas spremljati s pogostimi pregledi.