FrancophonIA/ELRC3.0 huggingface dataset:
English: If a child is unable to reliably swallow a Kaletra tablet, Kaletra oral solution formulation should be prescribed.
Danish: Hvis et barn ikke med sikkerhed er i stand til at synke en Kaletra tablet, skal formuleringen Kaletra-oral-opløsning ordineres.
English: Therefore, the antiviral activity of Kaletra is due to lopinavir.
Danish: Deraf udledes at Kaletras antivirale effekt skyldes lopinavir.
English: 4 tablets (400/100 mg) 5 tablets (500/125 mg)
Danish: 4 tabletter (400/100 mg) 5 tabletter (500/125 mg)
English: Ranitidine (150 mg single dose)
Danish: Ranitidin (150 mg enkeltdosis)
English: ≥ 15 to 40 kg
Danish: ≥ 15 til 40 kg
English: Particular risk of toxicity in relation to the amount of alcohol and propylene glycol contained in Kaletra oral solution
Danish: Særlig risiko for toksicitet i relation til den mængde af ethanol og propylenglycol, som Kaletra oral opløsning indeholder
English: Kaletra contains sodium as saccharin sodium, sodium chloride and sodium citrate, which may be harmful to people on a low sodium diet.
Danish: Kaletra indeholder natrium som saccharinnatrium, natriumchlorid og natriumcitrat, hvilket kan være skadeligt for personer på en diæt med lavt natriumindhold.
English: Kaletra is likely to increase plasma concentrations of medicinal products that are primarily metabolised by CYP3A.
Danish: Kaletra forårsager sandsynligvis en stigning i plasmakoncentrationen af lægemidler, der fortrinsvis metaboliseres af CYP3A.
English: In addition, virologic response was observed in 91% (21/23), 71% (15/21) and 33% (2/6) patients with 0 − 5, 6 − 7, and 8 − 10 mutations of the above mutations in HIV protease associated with reduced in vitro susceptibility to lopinavir.
Danish: Desuden blev et virologisk respons observeret hos 91 % (21/23), 71 % (15/21), og 33 % (2/6) patienter med henholdsvis 0-5, 6-7 og 8-10 mutationer af de mutationer i hiv-protease, der er nævnt ovenfor, som relaterer til nedsat følsomhed til lopinavir in vitro.
English: Patients had not been on prior lopinavir/ritonavir therapy.
Danish: Patienterne havde ikke tidligere været i behandling med lopinavir/ritonavir.
English: Modest decreases in amprenavir activity were noted with a median increase of IC50 from 3.7- to 8-fold in the baseline and rebound isolates, respectively.
Danish: Der blev set beskedent fald i amprenavir-aktivitet med en gennemsnitlig stigning af IC50 fra 3.7 - til 8-gange i henholdsvis baseline- og rebound-isolater.
English: For children weighing more than 15 kg
Danish: Til børn der vejer mere end 15 kg
English: Antidepressants and Anxiolytics Trazodone single dose
Danish: Antidepressiva og anxiolytika Trazodon enkeltdosis
English: Contraindicated when used for the treatment of pulmonary arterial hypertension (PAH) only.
Danish: Kun kontraindiceret ved brug til behandling af pulmonal arteriel hypertension (PAH).
English: During in vitro studies, cloned human cardiac potassium channels (HERG) were inhibited by 30% at the highest concentrations of lopinavir/ritonavir tested, corresponding to a lopinavir exposure 7-fold total and 15-fold free peak plasma levels achieved in humans at the maximum recommended therapeutic dose.
Danish: I In vitro studier blev klonede humane kardiale kalium kanaler (HERG) inhiberet 30 % af de højeste testede koncentrationer af lopinavir/ritonavir, svarende til en lopinavir eksponering på 7 gange det totale og 15 gange det frie peak plasma niveau, som opnås i mennesker ved de maksimalt anbefalede doser.
English: HIV-1 has been passaged in vitro with lopinavir alone and with lopinavir plus ritonavir at concentration ratios representing the range of plasma concentration ratios observed during Kaletra therapy.
Danish: Hiv-1 blev inkuberet in vitro med lopinavir alene og med lopinavir plus ritonavir i koncentrationer, der svarer til de forskellige plasmakoncentrationer, der ses under behandling med Kaletra.
English: Lopinavir is essentially completely metabolised by CYP3A.
Danish: Lopinavir er grundlæggende fuldstændigt metaboliseret af CYP3A.
English: Study P1060 was a randomised controlled trial of nevirapine versus lopinavir/ritonavir-based therapy in subjects 2 to 36 months of age infected with HIV-1 who had (Cohort I) and had not (Cohort II) been exposed to nevirapine during pregnancy for prevention of mother-to-child transmission.
Danish: Studie P1060 var et randomiseret, kontrolleret studie af nevirapin sammenlignet med lopinavir/ritovanir basis-behandling hos forsøgspersoner på 2 til 36 måneder inficeret med hiv-1, som havde (kohorte I) og ikke havde (kohorte II) været udsat for nevirapin under graviditeten for at forebygge mor-til-barn overførsel.
English: Long-term carcinogenicity studies of lopinavir/ritonavir in mice revealed a nongenotoxic, mitogenic induction of liver tumours, generally considered to have little relevance to human risk.
Danish: Langtids karcinogenicitetsstudier af lopinavir/ritonavir i mus viste en ikke genotoksisk, mitogen induktion af levertumorer, som generelt menes at have lille relevans for mennsker.
English: To date, there is limited human experience of acute overdose with Kaletra.
Danish: Der er begrænset erfaring med en akut overdosis af Kaletra i mennesker.
English: In use storage: If kept outside of the refrigerator, do not store above 25°C and discard any unused contents after 42 days (6 weeks).
Danish: Opbevaring efter åbning: Hvis Kaletra opbevares udenfor køleskab, bør det ikke opbevares over 25°C og smid al ubrugt indhold ud efter 42 dage (6 uger).
English: Kaletra has been shown in vivo to induce its own metabolism and to increase the biotransformation of some medicinal products metabolised by cytochrome P450 enzymes (including CYP2C9 and CYP2C19) and by glucuronidation.
Danish: Det er vist in vivo, at Kaletra inducerer sin egen metabolisme samt øger biotransformationen af visse lægemidler, som metaboliseres ved hjælp af cytocrom P450 enzymer (inklusive CYP2C9 og CYP2C19) og ved glucuronidering.
English: Medicinal products within class
Danish: Lægemiddelklasse Lægemidler i klassen
English: Macrogols type 400 (Polyethylene glycol 400) Hydroxypropyl cellulose Talc
Danish: Macrogoler type 400 (polyethylen glycol 400) Hydroxypropylcellulose Talcum
English: Through Week 96, genotypic resistance testing results were available from 25 patients in the QD group and 26 patients in the BID group who had incomplete virologic response.
Danish: Genotype resistenstestresultater var tilgængelige til og med uge 96, fra 25 patienter i QD-gruppen og 26 patienter i BID-gruppen, som havde ufuldstændigt virologisk response.
English: At steady state, lopinavir protein binding remains constant over the range of observed concentrations after 400/100 mg Kaletra twice daily, and is similar between healthy volunteers and HIV-positive patients.
Danish: Ved steady-state forbliver lopinavir proteinbinding konstant, ved en række observerede koncentrationer, efter 400/100 mg Kaletra to gange dagligt, og den er sammenlignelig mellem raske frivillige og hiv-positive patienter.
English: Mean age of patients enrolled was 39 years (range: 19 to 71); 75% were Caucasian, and 78% were male.
Danish: Gennemsnitsalderen for de inrullerede patienter var 39 år (interval: 19 til 71); 75% var kaukasere, og 78% var mænd.
English: • muscle disorders such as weakness and spasms, pain in the joints, muscles and back;
Danish: • muskellidelser så som svaghed eller spasmer, smerter i led, muskler og ryg;
English: Ritonavir has been shown to induce metabolic enzymes, resulting in the induction of its own metabolism, and likely the induction of lopinavir metabolism.
Danish: Det er vist, at ritonavir inducerer metabolske enzymer, som forårsager induktion af dens egen metabolisme, og sandsynligvis induktion af lopinavir metabolisme.
English: Corticosteroids Dexamethasone
Danish: Kortikosteroider Dexamethason
English: • Nausea, vomiting, abdominal pain as large increases in the amount of triglycerides (fats in the blood) have been considered a risk factor for pancreatitis (inflammation of the pancreas) and these symptoms may suggest this condition.
Danish: • Kvalme, opkastning og mavesmerter, da en stor stigning i mængden af triglycerider (fedtstoffer i blodet) anses for at være en risikofaktor for pankreatitis (betændelse i bugspytkirtlen), og disse symptomer kan tyde på denne sygdom.
English: Bepridil, Systemic Lidocaine, Quinidine:
Danish: Bepridil, systemisk lidocain, quinidin:
English: Further dosage reduction of rifabutin to 150 mg twice weekly on set days is recommended for patients in whom the 150 mg dose 3 times per week is not tolerated.
Danish: Der anbefales yderligere dosisreduktion af rifabutin til 150 mg to gange ugentlig på fastsatte dage til patienter, som ikke tåler dosis på 150 mg 3 gange om ugen.
English: The mean steady-state trough concentration prior to the morning dose was 5.5 ± 5.4 µg/ml.
Danish: Den gennemsnitlige steady-state through-koncentration forud for morgendosen var 5,5 ± 5,4 µg/ml.
English: The combined effects may lead to increased blood alcohol levels and increase the side effects of alcohol.
Danish: Den kombinerede effekt kan føre til øgede alkholmængder i blodet og øge bivirkningerne af alkohol.
English: Adverse events of nausea, dizziness, hypotension and syncope were observed following co-administration of trazodone and ritonavir.
Danish: Bivirkninger som kvalme, svimmelhed, hypotension og synkope er set efter samtidig administration af trazodon og ritonavir.
English: • cisapride (used to relieve certain stomach problems);
Danish: • cisaprid (brugt til lindring af visse maveproblemer);
English: 300/75 mg/m2 (corresponding to 3.75 ml/m2)
Danish: 300/75 mg/m2 (svarende til 3,75 ml/m2)
English: Co-administered drug by therapeutic area
Danish: Samtidigt administreret lægemiddel efter terapeutisk område
English: Haemophiliac patients should therefore be made aware of the possibility of increased bleeding.
Danish: Patienter med hæmofili bør gøres opmærksom på muligheden for øget blødningstendens.
English: In rats, embryofoetotoxicity (pregnancy loss, decreased foetal viability, decreased foetal body weights, increased frequency of skeletal variations) and postnatal developmental toxicity (decreased survival of pups) was observed at maternally toxic dosages.
Danish: Embryoføtotoksisitet (spontan abort, nedsat føtal levedygtighed, nedsat føtal kropsvægt, øget frekvens af skeletforandringer) og postnatal udviklingstoksisitet (nedsat overlevelse af afkom) var observeret i rotter ved maternelt toksiske doser.
English: • In use storage: If kept outside of the refrigerator, do not store above 25°C and discard any unused contents after 42 days (6 weeks).
Danish: • Opbevaring efter åbning: Hvis Kaletra opbevares udenfor køleskab, må du ikke opbevare det ved temperaturer over 25°C, og du skal smide al ubrugt indhold ud efter 42 dage (6 uger).
English: Rinse the syringe and plunger with clean water.
Danish: Rengør sprøjten og pumpestemplet med rent vand.
English: Place the tip of the syringe into the liquid.
Danish: Placer spidsen af sprøjten i væsken.
English: For volumes up to 2 ml.
Danish: Til voluminer op til 2 ml.
English: 16/4 mg/kg (corresponding to 0.2 ml/kg)
Danish: 16/4 mg/kg (svarende til 0,2 ml/kg)
English: Genotypic correlates of reduced phenotypic susceptibility to lopinavir in viruses selected by other protease inhibitors.
Danish: Genotypiske korrelationer for nedsat fænotypisk følsomhed overfor lopinavir i virus udvalgt ved brug af andre proteasehæmmere.
English: AUC0-12 μg•hr/mL
Danish: AUC0-12 μg•time/ml
English: Adverse reactions from clinical trials and post-marketing experience in adult and paediatric patients:
Danish: Bivirkninger fra kliniske studier og erfaring postmarketing fra voksne og pædiatriske patienter:
English: Elevated transaminases with or without elevated bilirubin levels have been reported in HIV-1 mono-infected and in individuals treated for post-exposure prophylaxis as early as 7 days after the initiation of lopinavir/ritonavir in conjunction with other antiretroviral agents.
Danish: Forhøjede aminotransferaser med eller uden forhøjede bilirubinniveauer er rapporteret hos hiv-1mono-inficerede og hos personer behandlet profylaktisk efter eksponering allerede 7 dage efter opstart af behandling med lopinavir/ritonavir sammen med andre antiretrovirale midler.
English: • lurasidone (used to treat depression);
Danish: • lurasidon (bruges til behandling af depression);
English: Tell your doctor if you or your child experience
Danish: Fortæl det til lægen, hvis du eller dit barn oplever
English: • The usual adult dose is 400 mg/100 mg twice a day i.e. every 12 hours, in combination with other anti-HIV medicines.
Danish: • Den sædvanlige voksendosis er 400 mg/100 mg to gange dagligt, dvs. hver 12. time, sammen med andre anti-hiv-lægemidler.
English: Not known Stevens-Johnson syndrome, erythema multiforme
Danish: Stevens-Johnsons syndrom og erythema multiforme
English: • Breast-feeding mothers should not take Kaletra unless specifically directed by the doctor.
Danish: • Ammende kvinder må ikke tage Kaletra uden lægens specifikke anvisning.
English: Patients who exhibit these signs or symptoms should be evaluated and Kaletra therapy should be suspended if a diagnosis of pancreatitis is made (see section 4.8).
Danish: Patienter, der har disse tegn eller symptomer, bør vurderes, og Kaletra behandling bør seponeres, hvis diagnosen pankreatitis stilles (se pkt.
English: Experienced patients received nevirapine plus up to two nucleoside reverse transcriptase inhibitors.
Danish: Patienter med forudgående behandling fik nevirapin plus op til to nukleosid revers transkriptasehæmmere.
English: No human data on the effect of lopinavir/ritonavir on fertility are available.
Danish: Der er ingen tilgængelige humane data vedrørende lopinavirs effekt på fertilitet.
English: Sedatives/hypnotics Oral midazolam, triazolam Increased plasma concentrations of oral midazolam and triazolam.
Danish: Sedativer/hypnotika Oral midazolam, triazolam Forhøjede plasmakoncentrationer af oral midazolam samt triazolam.
English: • In some patients with advanced HIV infection and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Danish: • Hos nogle patienter med fremskreden hiv-infektion, som tidligere har haft opportunistisk infektion, kan tegn og symptomer på betændelse fra tidligere infektioner forekomme kort efter, at anti-hiv-behandlingen er startet.
English: 1 See section 4.4: pancreatitis and lipids c. Description of selected adverse reactions
Danish: 1 Se pkt 4.4 : pankreatitis og lipider c. Beskrivelse af udvalgte bivirkninger
English: Anaemia, leucopenia, neutropenia, lymphadenopathy
Danish: Anæmi, leukopeni, neutropeni, lymfadenopati
English: Hepatitis C virus direct acting antivirals
Danish: Direkte virkende antivirale midler, mod hepatitis C-virus
English: AUC12 (µg•h/ml) Age ≥ 14 days to < 6 weeks cohort (N = 9):
Danish: AUC12 (µg•time/ml) Alder ≥ 14 dage til < 6 uger kohorte (N = 9):
English: Co-administration with other HIV protease inhibitors (PIs) According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended.
Danish: Samtidig administration med andre hiv-proteasehæmmere (PIs) I henhold til gældende behandlingsvejledninger anbefales samtidig behanding med to proteasehæmmere generelt ikke.
English: If the use of atorvastatin is considered strictly necessary, the lowest possible dose of atorvastatin should be administered with careful safety monitoring.
Danish: Hvis anvendelse af atorvastatin findes strengt nødvendig, bør den lavest mulig dosis gives med omhyggelig overvågning af sikkerheden.
English: Furthermore, polyoxol 40 hydrogenated castor oil and potassium present in Kaletra oral solution may cause only at high inadvertent doses gastrointestinal upset.
Danish: Derudover kan indholdet af polyoxol 40 hydrogeneret amerikansk olie og kalium i Kaletra oral opløsning forårsage gastrointestinale gener ved utilsigtet høje doser.
English: A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 (e.g. beclomethasone).
Danish: En dosisreduktion af glucokorticoid bør overvejes med nøje overvågning af lokale og systemiske virkninger eller et skift til et glukokortikoid, som ikke er et substrat for CYP3A4 (f.eks. beclomethason).
English: Increased plasma concentrations of quetiapine which may lead to coma.
Danish: Forhøjede plasmakoncentrationer af quetiapin, som kan føre til koma.
English: Omeprazole: ↔ Lopinavir: ↔
Danish: Omeprazol: ↔ Lopinavir: ↔
English: • dizziness, anxiety, difficulty in sleeping;
Danish: • svimmelhed, angst, søvnløshed;
English: CYP3A4 inhibitors increase the exposure of lomitapide, with strong inhibitors increasing exposure approximately 27-fold.
Danish: CYP3A4-hæmmere øger lomitapids eksponering - for stærke hæmmere øges eksponeringen cirka 27 gange.
English: Kaletra pharmacokinetics have not been studied in patients with renal insufficiency; however, since the renal clearance of lopinavir is negligible, a decrease in total body clearance is not expected in patients with renal insufficiency.
Danish: Farmakokinetiske parametre af Kaletra er ikke blevet undersøgt hos patienter med nyreinsufficiens, men da renal clearance af lopinavir er ubetydelig, forventes ingen nedgang af kroppens samlede clearance hos patienter med nyreinsufficiens.
English: Plasma concentrations of lopinavir were measured over four 12-hour periods during second trimester (20-24 weeks gestation), third trimester before dose increase (30 weeks gestation), third trimester after dose increase (32 weeks gestation), and at 8 weeks post-partum.
Danish: Lopinavirs plasmakoncentrationer blev målt over fire 12-timers perioder i det andet trimester (gestationsuge 20-24), tredie trimester inden dosisøgning (gestationsuge 30), tredie trimester efter dosisøgning (gestationsuge 32) og 8 uger efter fødslen.
English: HIV CCR5 - antagonist Maraviroc
Danish: Hiv-CCR5-antagonister Maraviroc
English: The safety of Kaletra has been investigated in over 2600 patients in Phase II-IV clinical trials, of which over 700 have received a dose of 800/200 mg (6 capsules or 4 tablets) once daily.
Danish: Sikkerheden af Kaletra er blevet undersøgt hos over 2.600 patienter i kliniske afprøvninger fase II/IV.Over 700 fik en dosis på 800/200 mg (6 kapsler eller 4 tabletter) en gang dagligt.
English: Kaletra oral solution contains approximately 42% v/v alcohol.
Danish: Kaletra oral opløsning indeholder omkring 42 % v/v alkohol.
English: Lower concentrations of lopinavir/ritonavir did not produce significant potassium (HERG) current blockade.
Danish: Lavere koncentrationer af lopinavir/ritonavir gav ikke nogen signifikant kalium (HERG) strøm blokade.
English: • People taking Kaletra may still develop infections or other illnesses associated with HIV disease and AIDS.
Danish: • Personer, der tager Kaletra, kan stadig udvikle infektioner eller andre sygdomme forbundet med hiv og AIDS.
English: A limited increase in total lopinavir concentrations of approximately 30% has been observed which is not expected to be of clinical relevance (see section 4.2).
Danish: En begrænset stigning i total lopinavir koncentrationer på omkring 30 %, som ikke forventes at have klinisk relevans, blev observeret (se pkt.
English: In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic infections may arise.
Danish: Hos hiv-inficerede patienter med alvorlig immundefekt ved indledningen af antiretroviral kombinationsbehandling (CART) kan der opstå en inflammatorisk reaktion på asymptomatiske eller residuale opportunistiske infektioner.
English: Read the list of medicines above ‘Do not take Kaletra with any of the following medicines' for information on medicines that you must not take with Kaletra.
Danish: Se listen over lægemidler ovenfor under ‘Tag ikke Kaletra sammen med nogen af følgende lægemidler' for at få oplysninger om lægemidler, som du ikke må tage sammen med Kaletra.
English: 6/75 (8%) patients demonstrated new primary protease inhibitor mutations (codons 30, 32, 48, 50, 82, 84, 90), as did 12/77 (16%) patients in the BID group.
Danish: I QD-gruppen, viste 6/75 (8%) patienter nye primære proteasehæmmer mutationer (codon 30, 32, 48, 50, 82, 84, 90), ligesom 12/77 (16%) patienter i BID-gruppen.
English: Lopinavir is extensively metabolised by the hepatic cytochrome P450 system, almost exclusively by isozyme CYP3A.
Danish: Lopinavir er i høj grad metaboliseret af det hepatiske cytokrom-P450 system, næsten udelukkende af isoenzym CYP3A.
English: Protocol defined non-inferiority of once-daily dosing compared with twice-daily dosing was demonstrated if the lower bound of the 95% confidence interval for the difference in proportion of subjects responding (once daily minus twice daily) excluded -12% at Week 48.
Danish: Protokoldefineret non-inferioritet af dosering en gang dagligt sammenlignet med dosering to gange dagligt blev påvist, hvis den nedre grænse af 95%-konfidensintervallet for forskellen i forholdet af forsøgspersoner, som responderede (en gang dagligt minus to gange dagligt) udelukkede -12% ved uge 48.
English: Cisapride
Danish: Cisaprid
English: Postpartum n = 17**
Danish: Efter fødslen n = 17**
English: Lamotrigine and Valproate
Danish: Lamotrigin og valproat
English: • lovastatin, simvastatin (used to lower blood cholesterol);
Danish: • lovastatin, simvastatin (bruges til at sænke kolesterol i blodet);
English: Initially, bosentan Cmin: ↑ by approximately 48-fold.
Danish: Initialt, bosentan Cmin: ↑ omkring 48-gange.
English: The two regimens resulted in exposures on Day 3 which were approximately 1.5 and 3-fold higher than those observed with recommended once daily or twice daily LPV/r doses at steady state.
Danish: Ved steady state resulterede de to regimer i ekspositioner på dag 3, som var tilnærmelsesvis 1,5 og 3-gange højere end dem, som blev set med den anbefalede LPV/r dosis en gang dagligt eller to gange dagligt.
English: The 4-oxo and 4-hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.
Danish: 4oxo- og 4-hydroxymetabolit epimere par er de primære metabolitter med antiviral effekt, men de udgør kun en lille del af den samlede plasmaradioaktivitet.
English: Inhaled, injectable or intranasal fluticasone propionate, budesonide, triamcinolone
Danish: Inhalations-, injektionseller intranasal fluticasonpropionat, budesonid, triamcinolon
English: • The usual adult dose is 5 ml of the oral solution twice a day i.e. every 12 hours, in combination with other anti-HIV medicines.
Danish: • Den sædvanlige dosis er 5 ml af den orale opløsning to gange dagligt, f.eks. hver 12. time i kombination med andre lægemidler mod hiv.
English: • If you realise you have taken more Kaletra than you were supposed to, contact your doctor right away.
Danish: • Hvis du bliver klar over, at du har taget for meget Kaletra, skal du straks kontakte din læge.
English: Antipsychotics Lurasidone
Danish: Antipsykotika Lurasidon
English: No age or gender related pharmacokinetic differences have been observed in adult patients.
Danish: Der er ikke fundet nogle farmakokinetiske forskelle relateret til køn i voksne patienter.
English: 7 to 10 kg > 10 to < 15 kg
Danish: 7 til 10 kg > 10 til < 15 kg
English: Kaletra soft capsules and liquid have been shown to be bioequivalent under nonfasting conditions (moderate fat meal).
Danish: Kaletra bløde kapsler og Kaletra oral opløsning er bioækvivalente under ikke-fastende betingelser (mad med moderat fedtindhold).
English: Very common Upper respiratory tract infection Common
Danish: Meget almindelig Øvre luftvejsinfektioner Almindelig
English: Through Week 48, genotypic resistance testing results were available from 75 patients in the QD group and 75 patients in the BID group who had incomplete virologic response.
Danish: Genotype resistenstestresultater var tilgængelige til og med uge 48, fra 75 patienter i QD-gruppen og 75 patienter i BID-gruppen, som havde ufuldstændigt virologisk response.