FrancophonIA/ELRC3.0 huggingface dataset:
English: Based upon in vitro studies, the circulating metabolites of duloxetine are considered pharmacologically inactive.
Croatian: Na temelju rezultata ispitivanja in vitro, metaboliti duloksetina u krvnom optoku smatraju se farmakološki neaktivnima.
English: The most commonly reported adverse reactions in patients treated with Duloxetine Lilly were nausea, headache, dry mouth, somnolence, and dizziness.
Croatian: Najčešće prijavljene nuspojave u bolesnika liječenih lijekom Duloksetin Lilly bile su mučnina, glavobolja, suha usta, somnolencija i omaglica.
English: − are taking or have taken within the last 14 days, another medicine known as a monoamine oxidase inhibitor (MAOI) (see ‘Other medicines and Duloxetine Lilly')
Croatian: − ako uzimate ili ste u posljednjih 14 dana uzimali drugi lijek koji se zove inhibitor monoaminooksidaze (MAOI) (pogledajte „Drugi lijekovi i Duloksetin Lilly“)
English: The safety and efficacy of duloxetine for the treatment of diabetic peripheral neuropathic pain has not been studied.
Croatian: Sigurnost i djelotvornost duloksetina za liječenje boli kod dijabetičke periferne neuropatije nisu ispitivane.
English: Anticoagulants and antiplatelet agents: Caution should be exercised when duloxetine is combined with oral anticoagulants or antiplatelet agents due to a potential increased risk of bleeding attributable to a pharmacodynamic interaction.
Croatian: Antikoagulansi i antitrombotici: Duloksetin se mora s oprezom kombinirati s oralnim antikoagulansima ili antitrombocitnim lijekovima jer je moguć povećan rizik od krvarenja koji se pripisuje farmakodinamičkoj interakciji.
English: As with other serotonergic medicinal products, discontinuation symptoms may occur in the neonate after maternal duloxetine use near term.
Croatian: Kao i kod drugih serotoninergičkih lijekova, moguća je pojava simptoma ustezanja u novorođenčeta ako je majka uzimala duloksetin u vrijeme blizu porođaja.
English: As the safety of duloxetine in infants is not known, the use of Duloxetine Lilly while breast-feeding is not recommended.
Croatian: Budući da sigurnost primjene duloksetina u dojenčadi nije poznata, ne preporučuje se primjena lijeka Duloksetin Lilly u dojilja.
English: • diabetic neuropathic pain (often described as burning, stabbing, stinging, shooting or aching or like an electric shock.
Croatian: • boli kod dijabetičke neuropatije (često se opisuje kao goruća, probadajuća, žareća, sijevajuća ili tupa bol ili kao bol nalik elektrošoku.
English: Inhibitors of CYP1A2: Because CYP1A2 is involved in duloxetine metabolism, concomitant use of duloxetine with potent inhibitors of CYP1A2 is likely to result in higher concentrations of duloxetine.
Croatian: Inhibitori CYP1A2: Budući da CYP1A2 sudjeluje u metabolizmu duloksetina, istodobna primjena duloksetina s potentnim inhibitorima CYP1A2 vjerojatno će dovesti do povišenih koncentracija duloksetina.
English: 9 Estimated frequency based on all clinical trial data.
Croatian: Učestalost procijenjena na temelju svih podataka iz kliničkih ispitivanja.
English: Fluvoxamine (100 mg once daily), a potent inhibitor of CYP1A2, decreased the apparent plasma clearance of duloxetine by about 77% and increased AUCo-t 6-fold.
Croatian: Fluvoksamin (100 mg jednom dnevno), potentan inhibitor CYP1A2, smanjio je prividni klirens duloksetina iz plazme za približno 77% i šesterostruko povećao AUCo-t.
English: Female rats receiving duloxetine (45 mg/kg/day) before and during mating and early pregnancy had a decrease in maternal food consumption and body weight, oestrous cycle disruption, decreased live birth indices and progeny survival, and progeny growth retardation at systemic exposure levels estimated to be at the most at maximum clinical exposure (AUC).
Croatian: U ženki štakora koje su primale duloksetin (45 mg/kg/dan) prije i tijekom parenja te u ranoj fazi graviditeta uočen je smanjen unos hrane i smanjenje tjelesne težine, prekid estrusnog ciklusa, smanjen indeks živookoćene mladunčadi, smanjeno preživljenje mladunčadi te zaostajanje u rastu mladunčadi pri razini sustavne izloženosti koja je odgovarala maksimalnoj kliničkoj izloženosti (AUC).
English: The no-adverse effect level was determined to be 20 mg/kg/day.
Croatian: Razina izloženosti pri kojoj nisu opaženi štetni učinci iznosila je 20 mg/kg na dan.
English: • vomiting blood, or black tarry stools (faeces), gastroenteritis, burping, difficulty swallowing
Croatian: • povraćanje krvi ili crna katranasta stolica (feces), gastroenteritis, podrigivanje, otežano gutanje
English: What Duloxetine Lilly is and what it is used for What you need to know before you take Duloxetine Lilly How to take Duloxetine Lilly Possible side effects
Croatian: Što je Duloksetin Lilly i za što se koristi Što morate znati prije nego počnete uzimati Duloksetin Lilly Kako uzimati Duloksetin Lilly
English: The usually recommended starting dose of Duloxetine Lilly is 30 mg once a day after which most patients will receive 60 mg once a day, but your doctor will prescribe the dose that is right for you.
Croatian: Uobičajena preporučena početna doza lijeka Duloksetin Lilly je 30 mg jednom na dan, nakon čega će većina bolesnika primati 60 mg jednom na dan, no liječnik će propisati dozu koja Vama najbolje odgovara.
English: These two studies included a 10 week placebo and active (fluoxetine) controlled acute phase followed by six months period of active controlled extension treatment.
Croatian: Ta su dva ispitivanja obuhvaćala 10-tjednu akutnu fazu kontroliranu placebom i aktivnim lijekom (fluoksetinom), nakon koje je uslijedio 6-mjesečni, aktivnim lijekom kontrolirani, produžetak ispitivanja.
English: Duloxetine Lilly is indicated in adults.
Croatian: Duloksetin Lilly je indiciran kod odraslih.
English: Duloxetine is detected in breast milk, and steady-state concentrations in breast milk are about one-fourth those in plasma.
Croatian: Duloksetin je pronađen u majčinom mlijeku, a koncentracije u majčinom mlijeku u stanju dinamičke ravnoteže iznose otprilike jednu četvrtinu koncentracija u plazmi.
English: • serious allergic reaction which causes difficulty in breathing or dizziness with swollen tongue or lips, allergic reactions
Croatian: • teška alergijska reakcija koja uzrokuje otežano disanje ili omaglicu te oticanje jezika ili usana,
English: 4.4 Special warnings and precautions for use
Croatian: 4.4 Posebna upozorenja i mjere opreza pri uporabi Manija i napadaji
English: Serotonergic agents: In rare cases, serotonin syndrome has been reported in patients using SSRIs/SNRIs concomitantly with serotonergic agents.
Croatian: Serotoninergički lijekovi: U rijetkim je slučajevima prijavljen serotoninski sindrom u bolesnika koji su uzimali SSRI-je/SNRI-je istodobno sa serotoninergičkim lijekovima.
English: c. Description of selected adverse reactions
Croatian: Opis odabranih nuspojava
English: CNS medicinal products: The risk of using duloxetine in combination with other CNS-active medicinal products has not been systematically evaluated, except in the cases described in this section.
Croatian: Lijekovi koji djeluju na središnji živčani sustav (SŽS): Rizici pri uzimanju duloksetina u kombinaciji s drugim lijekovima koji djeluju na SŽS nisu sustavno ocijenjeni, osim u slučajevima opisanima u ovom dijelu.
English: The disposition of duloxetine was studied in 6 lactating women who were at least 12-weeks postpartum.
Croatian: Dojilje Raspoloživost duloksetina ispitana je u 6 dojilja kojima je prošlo najmanje 12 tjedana od poroda.
English: However, data on elderly patients exposed to the maximum dose (120 mg per day) are limited and, thus, caution is recommended when using this dose with the elderly population.
Croatian: Međutim, podaci o starijim bolesnicima izloženima maksimalnoj dozi (120 mg na dan) su ograničeni i stoga se preporučuje oprez kod primjene te doze u populaciji starijih bolesnika.
English: Caution should also be exercised when duloxetine is used with medicinal products that may impair its metabolism (see section 4.5).
Croatian: Oprez je također nužan i kada se duloksetin primjenjuje s lijekovima koji mogu oslabiti njegov metabolizam (vidjeti dio 4.5).
English: After consolidation of the response, it is recommended to continue treatment for several months, in order to avoid relapse.
Croatian: Nakon što se postigne stalan odgovor na liječenje, preporučuje se nastaviti liječenje tijekom nekoliko mjeseci kako bi se izbjegao relaps.
English: You should use Duloxetine Lilly only after discussing the potential benefits and any potential risks to your unborn child with your doctor.
Croatian: Smijete uzimati Duloksetin Lilly tek nakon što razgovarate s liječnikom o mogućim koristima i rizicima za nerođeno dijete.
English: Duloxetine Lilly should be used with caution in patients with a history of mania or a diagnosis of bipolar disorder, and/or seizures.
Croatian: Duloksetin Lilly se mora s oprezom davati bolesnicima s manijom u anamnezi ili s dijagnozom bipolarnog poremećaja i/ili napadaja.
English: Eosinophilic pneumonia6
Croatian: eozinofilna pneumonija6
English: Duloxetine dose-dependently increases extracellular levels of serotonin and noradrenaline in various brain areas of animals.
Croatian: Duloksetin ovisno o dozi povisuje izvanstaničnu razinu serotonina i noradrenalina u različitim područjima mozga u životinja.
English: Therefore, caution should be exercised when treating the elderly with the maximum dosage (see sections 4.2 and 5.2).
Croatian: Stoga se u liječenju starijih osoba maksimalna doza mora primjenjivati s oprezom (vidjeti dijelove 4.2 i 5.2).
English: The model-predicted duloxetine steady state plasma concentrations in paediatric patients were mostly within the concentration range observed in adult patients.
Croatian: Modelom predviđene koncentracije duloksetina u plazmi u stanju dinamičke ravnoteže u pedijatrijskih bolesnika uglavnom su bile unutar raspona koncentracija primijećenih u odraslih bolesnika.
English: Duloxetine should be used with caution in patients whose conditions could be compromised by an increased heart rate or by an increase in blood pressure.
Croatian: Duloksetin se mora primjenjivati uz oprez u bolesnika čije stanje može biti kompromitirano ubrzanjem srčane frekvencije ili povišenjem krvnog tlaka.
English: Withdrawal symptoms when treatment is discontinued are common, particularly if discontinuation is abrupt (see section 4.8).
Croatian: Simptomi ustezanja pri prekidu liječenja su česti, naročito ako se liječenje prekine naglo (vidjeti dio 4.8).
English: A total of 467 paediatric patients initially randomized to duloxetine in clinical trials experienced a 0.1 kg mean decrease in weight at 10-weeks compared with a 0.9 kg mean increase in 353 placebo-treated patients.
Croatian: U ukupno 467 pedijatrijskih bolesnika koji su u kliničkim ispitivanjima inicijalno randomizirani za primanje duloksetina, zabilježena je srednja vrijednost smanjenja tjelesne težine od 0,1 kg u 10. tjednu, u usporedbi sa srednjom vrijednošću porasta težine od 0,9 kg u 353 bolesnika koja su primala placebo.
English: The use of duloxetine has been associated with the development of akathisia, characterised by a subjectively unpleasant or distressing restlessness and need to move often accompanied by an inability to sit or stand still.
Croatian: Akatizija/psihomotorni nemir Primjena duloksetina povezana je s razvojem akatizije, koju karakterizira subjektivno neugodan ili tjeskoban nemir i potreba za kretanjem, često praćena nesposobnošću mirnog sjedenja ili stajanja.
English: Duloxetine is extensively metabolised by oxidative enzymes (CYP1A2 and the polymorphic CYP2D6), followed by conjugation.
Croatian: Opsežno se metabolizira oksidacijskim enzimima (CYP1A2 i polimorfnim CYP2D6), nakon čega se konjugira.
English: A meta-analysis of placebo-controlled clinical trials of antidepressant medicinal products in psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Croatian: Meta-analiza placebom kontroliranih kliničkih ispitivanja antidepresiva u liječenju psihijatrijskih poremećaja pokazala je povećan rizik od suicidalnog ponašanja kod primjene antidepresiva u odnosu na placebo u ispitanika mlađih od 25 godina.
English: During the 52-week placebocontrolled double blind treatment phase 14.4% of the duloxetine-treated patients and 33.1% of the placebo-treated patients experience a return of their depressive symptoms (p<0.001).
Croatian: Tijekom 52 tjedna placebom kontrolirane dvostruko slijepe faze liječenja u 14,4% bolesnika liječenih duloksetinom te u 33,1% bolesnika koji su primali placebo došlo je do povratka simptoma depresije (p<0,001).
English: Duloxetine binds to both albumin and alpha-l acid glycoprotein.
Croatian: Duloksetin se veže i za albumin i za alfa-1-kiseli glikoprotein.
English: Duloxetine Lilly is available in 2 strengths: 30 mg and 60 mg.
Croatian: Duloksetin Lilly je dostupan u 2 jačine: 30 mg i 60 mg.
English: Multipack: 100 (5 packs of 20) hard gastro-resistant capsules Multipack: 500 (25 packs of 20) hard gastro-resistant capsules
Croatian: Višestruko pakiranje: 100 (5 kutija s 20) tvrdih želučanootpornih kapsula Višestruko pakiranje: 500 (25 kutija s 20) tvrdih želučanootpornih kapsula
English: The recommended starting dose in patients with generalised anxiety disorder is 30 mg once daily with or without food.
Croatian: Preporučena početna doza za bolesnike s generaliziranim anksioznim poremećajem je 30 mg jednom dnevno, s hranom ili bez nje.
English: data on elderly patients exposed to the maximum dose (120mg per day) are limited and thus, caution is recommended when treating this population.
Croatian: Međutim, podaci o starijim bolesnicima izloženima maksimalnoj dozi (120 mg na dan) su ograničeni i stoga se preporučuje oprez kod liječenja ove populacije.
English: • painful urination, frequent urination
Croatian: • bolno mokrenje, često mokrenje
English: In general, the adverse reaction profile of duloxetine in children and adolescents was similar to that seen for adults.
Croatian: U načelu je profil nuspojava kod primjene duloksetina u djece i adolescenata bio sličan onome zabilježenom u odraslih osoba.
English: Studies in juvenile rats reveal transient effects on neurobehaviour, as well as significantly decreased body weight and food consumption; hepatic enzyme induction; and hepatocellular vacuolation at 45 mg/kg/day.
Croatian: Ispitivanja u mladih štakora ukazala su na prolazne učinke na neurološki status , ali i značajno smanjenje tjelesne težine i unosa hrane, indukciju jetrenih enzima te vakuolizaciju jetrenih stanica pri dozi od 45 mg/kg na dan.
English: Each capsule of Duloxetine Lilly contains pellets of duloxetine hydrochloride with a covering to protect them from stomach acid.
Croatian: Jedna Duloksetin Lilly kapsula sadrži granule duloksetinklorida s ovojnicom koja ih štiti od želučane kiseline.
English: Medicinal products metabolised by CYP2D6: Duloxetine is a moderate inhibitor of CYP2D6.
Croatian: Lijekovi koji se metaboliziraju pomoću CYP2D6: Duloksetin je umjereni inhibitor CYP2D6.
English: A randomised, double-blind, placebo-controlled study was performed in 272 patients aged 7-17 years with generalised anxiety disorder.
Croatian: Provedeno je randomizirano, dvostruko slijepo, placebom kontrolirano ispitivanje u 272 bolesnika u dobi od 7 do 17 godina s generaliziranim anksioznim poremećajem.
English: In both studies, Duloxetine Lilly 60 mg once daily and 60 mg twice daily significantly reduced pain compared with placebo.
Croatian: U oba je ispitivanja Duloksetin Lilly u dozi od 60 mg jednom dnevno i 60 mg dva puta dnevno značajno umanjio bol u usporedbi s placebom.
English: Medicinal products containing duloxetine
Croatian: Lijekovi koji sadrže duloksetin
English: Cases of liver injury, including severe elevations of liver enzymes (>10 times upper limit of normal), hepatitis and jaundice have been reported with duloxetine (see section 4.8).
Croatian: Kod primjene duloksetina prijavljeni su slučajevi oštećenja jetre, uključujući jako povišenje vrijednosti jetrenih enzima (> 10 puta iznad gornje granice normale), hepatitis i žuticu (vidjeti dio 4.8).
English: When duloxetine was administered at a dose of 60 mg twice daily with a single dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold.
Croatian: Kada je duloksetin u dozi od 60 mg dvaput dnevno primijenjen s jednom dozom dezipramina, supstrata izoenzima CYP2D6, AUC dezipramina se utrostručio.
English: Duloxetine Lilly should not be used in combination with fluvoxamine, ciprofloxacin or enoxacin (i.e. potent CYP1A2 inhibitors) since the combination results in elevated plasma concentrations of duloxetine (see section 4.5).
Croatian: Duloksetin Lilly se ne smije primjenjivati u kombinaciji s fluvoksaminom, ciprofloksacinom ili enoksacinom (tj. potentnim inhibitorima CYP1A2) jer se pri toj kombinaciji povećava koncentracija duloksetina u plazmi (vidjeti dio 4.5).
English: In the extension phase of these studies, which lasted up to 52 weeks, there was an increase in HbA1c in both the duloxetine and routine care groups, but the mean increase was 0.3% greater in the duloxetinetreated group.
Croatian: U produžetku tih ispitivanja, koje je trajalo do 52 tjedna, HbA1c se povećao i u skupini liječenoj duloksetinom i u skupini bolesnika na standardnom liječenju, ali je srednja vrijednost porasta bila za 0,3% veća u skupini koja je primala duloksetin.
English: • inflammation of the liver that may cause abdominal pain and yellowing of the skin or whites of the eyes
Croatian: • upala jetre koja može izazvati bol u trbuhu i žutilo kože ili bjeloočnica
English: At least 30% reported pain reduction was recorded in approximately 65% of duloxetine treated patients versus 40% for placebo.
Croatian: Smanjenje prijavljene boli za najmanje 30% zabilježeno je u približno 65% bolesnika liječenih duloksetinom, naspram 40% bolesnika koji su uzimali placebo.
English: Diabetic Peripheral Neuropathic Pain: The efficacy of Duloxetine Lilly as a treatment for diabetic neuropathic pain was established in 2 randomised, 12-week, double-blind, placebo-controlled, fixed dose studies in adults (22 to 88 years) having diabetic neuropathic pain for at least 6 months.
Croatian: Bol kod dijabetičke periferne neuropatije: Djelotvornost lijeka Duloksetin Lilly u liječenju boli kod dijabetičke neuropatije utvrđena je u dva randomizirana, 12-tjedna, dvostruko slijepa, placebom kontrolirana ispitivanja fiksnih doza u odraslih (u dobi od 22 do 88 godina) koji su imali bolnu dijabetičku neuropatiju najmanje 6 mjeseci.
English: Hypertensive crisis3,6
Croatian: periferna hladnoća hipertenzivna kriza3,6
English: Table 1 gives the adverse reactions observed from spontaneous reporting and in placebo-controlled clinical trials.
Croatian: U Tablici 1 prikazane su nuspojave prikupljene iz spontanih prijava i u placebom kontroliranim kliničkim ispitivanjima.
English: • dehydration, low levels of sodium in the blood (mostly in elderly people; the symptoms may include feeling dizzy, weak, confused, sleepy or very tired, or feeling or being sick, more serious symptoms are fainting, fits or falls), syndrome of inappropriate secretion of anti-diuretic hormone (SIADH)
Croatian: • dehidracija, niske razine natrija u krvi (uglavnom u starijih osoba; simptomi mogu uključivati omaglicu, slabost, zbunjenost, pospanost ili izrazit umor, mučninu ili povraćanje; ozbiljniji simptomi su nesvjestica, napadaji ili padovi), sindrom neprimjerenog izlučivanja antidiuretskog hormona (SIADH)
English: The study included a 10 week placebo-controlled acute phase, followed by an 18 week extension treatment period.
Croatian: 10-tjedne akutne faze kontrolirane placebom, iza koje je slijedilo 18-tjedno razdoblje produžetka liječenja.
English: Furthermore, increases in INR values have been reported when duloxetine was co-administered to patients treated with warfarin.
Croatian: Nadalje, zabilježene su povišene vrijednosti INR-a kada se duloksetin primjenjivao u bolesnika istodobno liječenih varfarinom.
English: • lack of appetite
Croatian: nedostatak motivacije
English: Paediatric population Duloxetine has not been studied in patients under the age of 7.
Croatian: Duloksetin nije ispitivan u bolesnika mlađih od 7 godina.
English: In an embryotoxicity study in the rabbit, a higher incidence of cardiovascular and skeletal malformations was observed at systemic exposure levels below the maximum clinical exposure (AUC).
Croatian: U istraživanju embriotoksičnosti u kunića uočena je povećana incidencija kardiovaskularnih i koštanih malformacija pri sustavnoj izloženosti manjoj od maksimalne kliničke izloženosti (AUC).
English: 5 Cases of suicidal ideation and suicidal behaviours have been reported during duloxetine therapy or early after treatment discontinuation (see section 4.4).
Croatian: 5 Slučajevi suicidalnih misli i suicidalnog ponašanja prijavljeni su tijekom terapije duloksetinom ili ubrzo nakon prekida terapije (vidjeti dio 4.4).
English: • Stevens-Johnson syndrome (serious illness with blistering of the skin, mouth, eyes and genitals), serious allergic reaction which causes swelling of the face or throat (angioedema)
Croatian: • zatajenje jetre, žutilo kože ili bjeloočnica (žutica) • Stevens-Johnsonov sindrom (ozbiljna bolest s mjehurićima na koži, ustima, očima i genitalijama), teška alergijska reakcija koja izaziva oticanje lica ili grla (angioedem)
English: It is therefore advised that duloxetine should be gradually tapered when discontinuing treatment over a period of no less than 2 weeks, according to the patient's needs (see section 4.2).
Croatian: Stoga se savjetuje da se kod prekida liječenja duloksetinom doza postupno smanjuje tijekom razdoblja od najmanje 2 tjedna, sukladno potrebama bolesnika (vidjeti dio 4.2).
English: Doses up to 120 mg per day have been shown to be efficacious and have been evaluated from a safety perspective in clinical trials.
Croatian: Pokazalo se da su doze do 120 mg učinkovite, a sigurnost njihove primjene ocijenjena je u kliničkim ispitivanjima.
English: Caution is advised in patients taking anticoagulants and/or medicinal products known to affect platelet function (e.g. NSAIDs or acetylsalicylic acid (ASA)), and in patients with known bleeding tendencies.
Croatian: Savjetuje se oprez u bolesnika koji uzimaju antikoagulanse i/ili lijekove koji utječu na funkciju trombocita (npr. NSAIL, acetilsalicilatna kiselina (ASK)) te u bolesnika s poznatom sklonošću krvarenjima.
English: 6 Estimated frequency of post-marketing surveillance reported adverse reactions; not observed in placebo-controlled clinical trials.
Croatian: 6 Procijenjena učestalost nuspojava prijavljenih tijekom praćenja nakon stavljanja lijeka u promet; nisu uočene u placebom kontroliranim kliničkim ispitivanjima.
English: Both cytochromes P450-2D6 and 1A2 catalyse the formation of the two major metabolites glucuronide conjugate of 4-hydroxy duloxetine and sulfate conjugate of 5-hydroxy 6-methoxy duloxetine.
Croatian: 2D6 i 1A2 kataliziraju stvaranje dvaju glavnih metabolita, glukuronidnog konjugata 4-hidroksi duloksetina i sulfatnog konjugata 5-hidroksi 6-metoksi duloksetina.
English: Hyponatraemia has been reported when administering Duloxetine Lilly, including cases with serum sodium lower than 110 mmol/l.
Croatian: Prijavljeni su slučajevi hiponatrijemije kod primjene lijeka Duloksetin Lilly, uključujući slučajeve sa serumskom koncentracijom natrija nižom od 110 mmol/l.
English: The pharmacokinetics of duloxetine in patients who are poor metabolisers with respect to CYP2D6 has not been specifically investigated.
Croatian: Farmakokinetika duloksetina u bolesnika koji su spori metabolizatori na CYP2D6 nije posebno ispitivana.
English: Discontinuation due to adverse events was higher in patients taking duloxetine compared with those treated with fluoxetine, mostly due to nausea.
Croatian: Prekid liječenja zbog nuspojava bio je češći u bolesnika koji su uzimali duloksetin u usporedbi s bolesnicima liječenima fluoksetinom, a najčešći je uzrok bila mučnina.