FrancophonIA/ELRC3.0 huggingface dataset:
English: On the other hand effective antiepileptic therapy must not be interrupted since the worsening of the disease is harmful to both the mother and the unborn child.
Danish: På den anden side må behandlingen med epilepsimedicin ikke afbrydes, da forværring af sygdommen kan skade både mor og barn.
English: The following convention has been used for the classification of adverse reactions very common
Danish: Der er benyttet følgende konvention til klassificering af bivirkningerne: meget almindelige ≥1/10,
English: Thus, an increase in the dose of the medicinal products that are mainly metabolised through CYP3A4 may be required, when used concomitantly with eslicarbazepine acetate.
Danish: Derfor kan det være nødvendigt at øge dosis af lægemidler, der især metaboliseres af CYP3A4, når de anvendes sammen med eslicarbazepinacetat.
English: • Crying, feeling depressed, nervous or confused, lack of interest or emotion;
Danish: • gråd, nedtrykthed, nervøsitet eller forvirring, ligegyldighed eller manglende følelser
English: • Disturbances in the sense of smell;
Danish: • forandringer i lugtesansen
English: Zebinix may make you feel dizzy, drowsy and affect your vision, particularly at the beginning of treatment.
Danish: Zebinix kan give svimmelhed og sløvhed og påvirke synet, særligt i begyndelsen af behandlingen.
English: • Irritability;
Danish: • irritabilitet
English: • simvastatin (a medicine used to lower cholesterol levels) since your dose may have to be adjusted;
Danish: • simvastatin (medicin til at sænke kolesteroltallet), da dosis måske skal justeres.
English: Rare adverse reactions such as bone marrow depression, anaphylactic reactions, systemic lupus erythematosus or serious cardiac arrhythmias did not occur during the placebo-controlled studies of the epilepsy program with eslicarbazepine acetate.
Danish: Der blev ikke observeret sjældne bivirkninger så som knoglemarvsdepression, anafylaktiske reaktioner, systemisk lupus erythematosus eller alvorlig arytmi under placebo-kontrollerede studier som led i epilepsiprogrammet med eslicarbazepinacetat.
English: The safety of Zebinix in children aged 6 years and below has not yet been established.
Danish: Zebinix's sikkerhed hos børn i alderen 6 år og derunder er endnu ikke klarlagt.
English: • Sweating or having dry skin;
Danish: • svedtendens eller tør hud
English: Zebinix oral suspension may be taken with or without food.
Danish: Zebinix oral suspension kan tages alene eller i forbindelse med et måltid.
English: In placebo-controlled studies involving patients aged from 2 to 18 years with partial-onset seizures (238 patients treated with eslicarbazepine acetate and 189 with placebo), 35.7% of patients treated with eslicarbazepine acetate and 19% of patients treated with placebo experienced adverse reactions.
Danish: I placebokontrollerede studier, der inkluderede patienter i alderen fra 2 til 18 år med fokale epileptiske anfald (238 patienter behandlet med eslicarbazepinacetat og 189 med placebo), oplevede 35,7 % af patienterne behandlet med eslicarbazepinacetat og 19 % af patienterne behandlet med placebo bivirkninger.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Intermediate carton of multipacks (without blue box)
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Karton for delpakning af multipakninger (uden blue box)
English: There was an average decrease of 36-39% in systemic exposure in healthy subjects when co-administered with eslicarbazepine acetate 1,200 mg once daily.
Danish: Der var et gennemsnitligt fald på 36-39 % i systemisk eksponering hos raske forsøgspersoner ved indgivelse samtidig med eslicarbazepinacetat 1.200 mg én gang dagligt.
English: In studies with eslicarbazepine in fresh human hepatocytes a mild induction of UGT1A1 mediated glucuronidation was observed.
Danish: I studier med eslicarbazepin i friske humane hepatocytter observeredes en svag induktion af glukuronidering, som skyldtes UGT1A1.
English: The safety and efficacy of eslicarbazepine acetate as adjunctive therapy for partial seizures in elderly patients were evaluated in one non-controlled study, with a duration of 26 weeks, in 72 elderly (aged ≥ 65 years).
Danish: Sikkerhed og virkning af eslicarbazepinacetat som tillægsbehandling til ældre patienter med fokale epileptiske anfald blev evalueret i ét ikke-kontrolleret studie med en varighed på 26 uger hos 72 ældre patienter (≥ 65 år).
English: • Flushing, cold limbs;
Danish: • blussen,kolde lemmer
English: In patients concomitantly treated with carbamazepine and eslicarbazepine acetate in placebocontrolled studies, the following adverse reactions were observed: diplopia (11.4% of subjects with concomitant carbamazepine, 2.4% of subjects without concomitant carbamazepine), abnormal coordination (6.7% with concomitant carbamazepine, 2.7% without concomitant carbamazepine), and dizziness (30.0% with concomitant carbamazepine, 11.5% without concomitant carbamazepine), see section 4.5.
Danish: Hos patienter i samtidig behandling med carbamazepin og eslicarbazepinacetat i placebokontrollerede studier blev følgende bivirkninger observeret: diplopi (11,4 % af forsøgspersoner med samtidig carbamazepin, 2,4 % af forsøgspersoner uden samtidig carbamazepin), abnorm koordination (6,7 % med samtidig carbamazepin, 2,7 % uden samtidig carbamazepin) og svimmelhed (30,0 % med samtidig carbamazepin, 11,5 % uden samtidig carbamazepin), se pkt.
English: • Reddish target-like macules or circular patches often with central blisters on the trunk, skin peeling, ulcers of mouth, throat, nose, genitals and eyes, red and swollen eyes and can be preceded by fever and/or flu-like symptoms (Stevens-Johnson syndrome/toxic epidermal necrolysis);
Danish: • rødlige pletter, der ligner skydeskiver, eller runde pletter på overkroppen, ofte med blærer i midten, hudafskalning, sår i mund, hals og næse, på kønsorganerne og i øjnene, røde og hævede øjne og kan komme efter feber og/eller influenzalignende symptomer (Stevens-Johnsons syndrom/toksisk epidermal nekrolyse)
English: Co-administration of eslicarbazepine acetate 1,200 mg once daily with warfarin showed a small (23%), but statistically significant decrease in exposure to S-warfarin.
Danish: Samtidig administration af eslicarbazepinacetat 1.200 mg en gang dagligt og warfarin viste et lille (23 %), men statistisk signifikant fald i eksponeringen for S-warfarin.
English: Thus, interactions can arise when co-administering high doses of eslicarbazepine acetate with medicinal products that are mainly metabolised by CYP2C19 (e.g. Phenytoin).
Danish: Der kan derfor opstå interaktion ved samtidig administration af høje doser eslicarbazepinacetat og lægemidler, der hovedsageligt metaboliseres af CYP2C19 (fx phenytoin).
English: Zebinix is not recommended if you have severe kidney problems.
Danish: De bør ikke anvende Zebinix, hvis De har svære nyreproblemer.
English: • Initially flu-like symptoms, rash on the face then widespread rash, high body temperature, liver enzyme elevations, blood abnormalities (eosinophilia), enlarged lymph nodes and other body organs involvement (Drug Reaction with Eosinophilia and Systemic Symptoms which is also known as DRESS or drug hypersensitivity syndrome);
Danish: • indledningsvis influenzalignende symptomer, udslæt i ansigtet siden udbredt udslæt, høj kropstemperatur, stigninger i leverenzymer, unormale blodværdier (eosinofili), forstørrede lymfeknuder og involvering af andre organer (lægemiddelreaktion med eosinofili og systemiske symptomer, der også er kendt som DRESS eller lægemiddeloverfølsomhedssyndrom)
English: • Diarrhoea;
Danish: • diarré
English: Headache, disturbance in attention, tremor, ataxia, balance disorder
Danish: Hovedpine, opmærksomhe dsforstyrrelser, tremor, ataksi, balanceforstyrr elser
English: The doses of the active comparator, carbamazepine controlled release, were 200 mg, 400 mg and 600 mg, twice-daily.
Danish: Dosis af den aktive komparator, carbamazepin-depotformulering, var 200 mg, 400 mg og 600 mg to gange dagligt.
English: Uncommon (may affect up to 1 in 100 people) side effects are:
Danish: Ikke almindelige bivirkninger (forekommer hos op til 1 ud af 100 personer):
English: Population pharmacokinetics indicate that comparable eslicarbazepine exposure is observed between 20 and 30 mg/kg/day in children above 6 years old and adults with 800 and 1200 mg of eslicarbazepine acetate once-daily, respectively (see section 4.2).
Danish: Populationsfarmakokinetikken viser, at der observeres sammenlignelig eksponering af eslicarbazepin mellem 20 og 30 mg/kg/dag hos børn over 6 år og voksne ved henholdsvis 800 og 1200 mg eslicarbazepinacetat en gang dagligt (se pkt.
English: 90 tablets.
Danish: 90 tabletter.
English: System Organ Class
Danish: Systemorganklasse Meget almindelige
English: The most common adverse reaction in the group treated with eslicarbazepine acetate were diplopia (5.0%), somnolence (8.0%) and vomiting (4.6%).
Danish: De mest almindelige bivirkninger i gruppen behandlet med eslicarbazepinacetat var diplopi (5,0 %), døsighed (8,0 %) og opkastning (4,6 %).
English: The proportion of patients with exacerbation (increase of ≥25%) compared to the baseline period was 14.2%.
Danish: Andelen af patienter med eksacerbation (stigning på ≥25 %) sammenlignet med baselineperioden var 14,2 %.
English: Children with a body weight of ≥60 kg
Danish: Børn med en kropsvægt på ≥ 60 kg
English: The total median standardised seizure frequency was 2.4 (resulting in a median relative change from Baseline Part III-V of -22.9%).
Danish: Total median standardiseret anfaldsfrekvens var 2,4 (hvilket resulterede i en median relativ forskel på -22,9% i forhold til del IIIV ved baseline).
English: Symptoms observed after an overdose of eslicarbazepine acetate are primarily associated with central nervous symptoms (e.g. seizures of all types, status epilepticus) and cardiac disorders (e.g. cardiac arrhythmia).
Danish: Efter en overdosis eslicarbazepinacetat er der primært observeret symptomer fra centralnervesystemet (f.eks. alle typer anfald, status epilepticus) og hjertelidelser (f.eks. hjertearytmi).
English: There have been reports of decreased bone mineral density, osteopenia, osteoporosis and fractures in patients on long-term therapy with the structurally related antiepileptic drugs carbamazepine and oxcarbazepine.
Danish: Der har været rapporter om nedsat knoglemineraltæthed, osteopeni, osteoporose og frakturer hos patienter i langvarig behandling med de strukturelt relaterede antiepileptika carbamazepin og oxcarbazepin.
English: The percentage of subjects with ≥50% reduction (1581 analyzed) in seizure frequency in the phase III studies was 19.3% for placebo, 20.8% for eslicarbazepine acetate 400 mg, 30.5% for eslicarbazepine acetate 800 mg and 35.3% for eslicarbazepine acetate 1,200 mg daily.
Danish: Procentdelen af forsøgspersoner med ≥ 50 % reduktion (1581 analyserede) i anfaldshyppighed i fase III-studierne var 19,3 % for placebo, 20,8 % for eslicarbazepinacetat 400 mg, 30,5 % for eslicarbazepinacetat 800 mg og 35,3 % for eslicarbazepinacetat 1.200 mg dagligt.
English: Taking into account that more eslicarbazepine acetate-treated patients experienced weight increase than weight decrease during the open label extension of the Phase III studies the current labelling is not considered adequate.
Danish: Idet det tages i betragtning, at flere eslicarbazepinacetat-behandlede patienter i den åbne forlængelse af fase 3-studierne oplevede en vægtstigning i forhold til patienter, der oplevede et vægttab, anses den nuværende produktinformation ikke for værende fyldestgørende.
English: • Reduction in blood platelets which increases risk of bleeding or bruising;
Danish: • nedsat antal blodplader og dermed øget risiko for blødninger og blå mærker
English: Zebinix has been given to you by your doctor to reduce your number of seizures.
Danish: Lægen har ordineret Zebinix til Dem for at nedsætte antallet af anfald.
English: Alopecia, dry skin, hyperhidrosis, erythema, skin disorder, pruritus, dermatitis allergic
Danish: Alopeci, tør hud, hyperhidrose, erytem, hudlidelser, pruritus, allergisk dermatitis
English: • Seeing double or blurred vision;
Danish: • dobbeltsyn eller uklart syn
English: Always use the oral syringe provided to take your medicine.
Danish: Brug altid mundsprøjten, der følger med lægemidlet.
English: There are some data that suggest HLA-A*3101 is associated with an increased risk of carbamazepine induced cutaneous adverse drug reactions including SJS, TEN, Drug rash with eosinophilia (DRESS), or less severe acute generalized exanthematous pustulosis (AGEP) and maculopapular rash in people of European descent and the Japanese.
Danish: Nogle data tyder på, at HLA-A*3101 er forbundet med en øget risiko for carbamazepin-inducerede kutane bivirkninger, herunder Stevens-Johnsons Syndrom (SJS), toksisk epidermal nekrolyse (TEN), lægemiddel-associeret udslæt med eosinofili (DRESS), eller de mindre alvorlige akut generaliseret eksantematøs pustulose (AGEP) og makulopapulært udslæt hos individer af europæisk og japansk oprindelse.
English: Method and route of administration Zebinix is for oral use.
Danish: Anvendelsesmåde og indgivelsesvej Zebinix er til indtagelse gennem munden.
English: Amongst these, when excluding patients aged 6 years and younger, 14 (48.3%) and 11 (30.6%) of patients in the eslicarbazepine acetate and placebo group, respectively, were responders (p=0.1514).
Danish: Hvis man ser bort fra patienter i alderen 6 år og derunder viste 14 (48,3 %) og 11 (30,6 %) af disse patienter i henholdsvis eslicarbazepinacetatog placebo-gruppen respons (p = 0,1514).
English: Zebinix may make hormonal contraceptives such as the contraceptive pill less effective.
Danish: Zebinix kan nedsætte sikkerheden af hormonelle præventionsmidler så som p-piller.
English: The starting dose is 10 mg per kg body weight taken once a day for one or two weeks, before increasing to the maintenance dose.
Danish: Startdosis er 10 mg pr. kg kropsvægt, der tages en gang dagligt i en eller to uger, inden der øges til vedligeholdelsesdosen.
English: Turn the bottle upright and remove the entire oral syringe from the bottle.
Danish: Vend flasken om, så den er lodret opad, og fjern hele mundsprøjten fra flasken.
English: Based on individual response, the dose of eslicarbazepine acetate may need to be increased and the dose of phenytoin may need to be decreased.
Danish: Afhængigt af den enkelte patients respons kan det være nødvendigt at øge doseringen af eslicarbazepinacetat og nedsætte doseringen af phenytoin.
English: Eslicarbazepine is a weak inducer of CYP3A4 and has inhibiting properties with respect to CYP2C19 (as stated in section 4.5).
Danish: Eslicarbazepin er en svag inducer af CYP3A4 og har hæmmende egenskaber over for CYP2C19 (som anført i pkt.
English: • Reduction in white blood cells which makes infections more likely;
Danish: • nedsat antal hvide blodlegemer og dermed øget risiko for infektion
English: It is unknown whether eslicarbazepine acetate is excreted in human milk.
Danish: Det er ukendt, om eslicarbazepinacetat/metabolitter udskilles i human mælk.
English: Shake well before use.
Danish: Rystes grundigt inden brug.
English: Contents of the pack and other information What Zebinix contains
Danish: Pakningsstørrelser og yderligere oplysninger Zebinix indeholder:
English: Insert the tip of the oral syringe into the bottle adapter opening, keeping the bottle upright.
Danish: Anbring spidsen af mundsprøjten i åbningen på flaskeadapteren, mens flasken holdes lodret opad.
English: Adverse reactions associated with eslicarbazepine acetate obtained from clinical studies and postmarketing surveillance are tabulated below.
Danish: Bivirkninger, der er forbundet med eslicarbazepinacetat og observeret i kliniske studier og ved overvågning efter markedsføring, er anført i nedenstående tabel.
English: In clinical studies (adjunctive therapy treatment and monotherapy), 2,434 patients with partial-onset seizures were treated with eslicarbazepine acetate (1,983 adult patients and 451 paediatric patients) and 51% of those patients experienced adverse reactions.
Danish: I kliniske studier (supplerende behandling og monoterapi) blev 2.434 patienter med fokale epileptiske anfald behandlet med eslicarbazepinacetat (1.983 voksne patienter og 451 pædiatriske patienter), og 51 % af disse patienter oplevede bivirkninger.
English: Each cardboard box contains a 10 ml polypropylene graduated syringe with 0.2 ml graduations, and a copolymer push-in bottle adapter.
Danish: Hver æske indeholder en 10 ml målesprøjte af polypropylen med 0,2 ml inddelinger og en flaskeadapter af copolymer til itrykning.
English: Aluminium / Aluminium or PVC/Aluminium blisters placed into cardboard boxes containing 20, 30, 60 or 90 tablets and in multi-packs containing 180 (2 packs of 90) tablets.
Danish: Aluminium/aluminium eller PVC/aluminium blisterkort i æsker med 20, 30, 60 eller 90 tabletter og i multipakninger indeholdende 180 (2 pakninger med 90) tabletter.
English: 7 tablets 14 tablets 28 tablets
Danish: 7 tabletter 14 tabletter 28 tabletter
English: Drug toxicity, fall, thermal burn
Danish: Lægemiddelstoksic itet, fald, brandsår
English: Gently pull the plunger of the oral syringe to the desired volume.
Danish: Træk forsigtigt stempel på mundsprøjten til det ønskede volumen.
English: If you forget to take Zebinix
Danish: Hvis De har glemt at tage Zebinix
English: Replace the closure on the bottle by turning it clock-wise (to the right).
Danish: Sæt låget på flasken ved at dreje med uret (mod højre).
English: The maximum dose is 1,200 mg once daily.
Danish: Den maksimale dosis er 1.200 mg en gang dagligt.
English: • if you have kidney problems.
Danish: • hvis De har dårlige nyrer.
English: The efficacy of eslicarbazepine acetate as adjunctive therapy has been demonstrated in four phase III double-blind placebo-controlled studies in 1,703 randomized adult patients with partial epilepsy refractory to treatment with one to three concomitant antiepileptic medicinal products.
Danish: Eslicarbazepinacetats virkning som supplerende behandling er påvist i fire dobbeltblinde, placebokontrollerede fase III-studier omfattende 1.703 randomiserede voksne patienter med fokal epilepsi, som var upåvirkelig af behandling med et til tre antiepileptika administreret samtidig.
English: If you stop taking Zebinix
Danish: Hvis De holder op med at tage Zebinix
English: If clinically-relevant hyponatraemia develops, eslicarbazepine acetate should be discontinued.
Danish: I tilfælde af klinisk relevant hyponatriæmi skal eslicarbazepinacetat seponeres.
English: Zebinix 50 mg/ml oral suspension Eslicarbazepine acetate
Danish: Zebinix 50 mg/ml oral suspension Eslicarbazepinacetat
English: Flavour Tutti-Frutti artificial (contains maltodextrin, propylene glycol, natural and artificial flavouring, and gum acacia (E414)
Danish: Kunstigt smagsstof Tutti-Frutti (indeholder maltodextrin, propylenglycol, naturlig og kunstig smagstilsætning samt akaciegummi (E414)
English: • the blood thinner - warfarin;
Danish: • den blodfortyndende medicin warfarin.
English: Push the plunger all the way down.
Danish: Pres stemplet helt i bund.
English: A study in healthy subjects showed no effect of eslicarbazepine acetate 1,200 mg once daily on digoxin pharmacokinetics, suggesting that eslicarbazepine acetate has no effect on the transporter Pglycoprotein.
Danish: I et studie med raske forsøgspersoner havde eslicarbazepinacetat 1.200 mg en gang dagligt ingen effekt på digoxins farmakokinetik, hvilket tyder på, at eslicarbazepinacetat ikke har nogen effekt på transportproteinet P-glykoprotein.
English: Eslicarbazepine acetate has been associated with some central nervous system adverse reactions, such as dizziness and somnolence, which could increase the occurrence of accidental injury.
Danish: Eslicarbazepinacetat er sat i forbindelse med visse bivirkninger i centralnervesystemet, fx svimmelhed og døsighed, som kan øge forekomsten af tilskadekomst.
English: Fatigue, gait disturbance, asthenia
Danish: Træthed, gangforstyrrelser, asteni
English: The most frequent individual adverse reactions were dizziness (12.5% of subjects), somnolence (9.7%), fatigue, convulsion and hyponatraemia (8.3%, each), nasopharyngitis (6.9%) and upper respiratory tract infection (5.6%).
Danish: De hyppigste individuelle bivirkninger var svimmelhed (12,5 % af forsøgspersonerne), døsighed (9,7 %), træthed, kramper og hyponatriæmi (8,3 % hver), nasofaryngitis (6,9 %) og infektion i de øvre luftveje (5,6 %).
English: Elderly (over 65 years of age) If you are elderly and taking Zebinix on its own the dose of 1,600 mg is not a suitable dose for you.
Danish: Hvis De er ældre og tager Zebinix som det eneste lægemiddel mod Deres epilepsi, er en dosis på 1.600 mg ikke egnet til Dem.
English: There have been reports of bone disorders including osteopenia and osteoporosis (thinning of the bone) and fractures with structurally related antiepileptics medicines like carbamazepine and oxcarbazepine.
Danish: Der har været rapporter om knoglelidelser, herunder osteopeni og osteoporose (knogleskørhed) og knoglebrud i forbindelse med behandling med beslægtede lægemidler mod epilepsi som carbamazepin og oxcarbazepin.
English: Outer carton / bottle
Danish: Ydre æske/flaske
English: The least square mean reduction in standardised seizure frequency from baseline to maintenance period was significantly (p<0.001) higher with eslicarbazepine acetate (-34.8%) compared to placebo (13.8%).
Danish: Mindste kvadraters-gennemsnitlige reduktion i standardiseret anfaldsfrekvens fra baseline til vedligeholdelsesperioden var signifikant (p < 0,001) højere med eslicarbazepinacetat (-34,8 %) sammenlignet med placebo (-13,8 %).
English: The pharmacokinetics of eslicarbazepine acetate has not been evaluated in patients with severe hepatic impairment.
Danish: Eslicarbazepinacetats farmakokinetik er ikke undersøgt hos patienter med alvorligt nedsat leverfunktion.
English: During treatment with Zebinix dose adjustment is recommended in patients, adult and children above 6 years of age with creatinine clearance <60 ml/min (see section
Danish: Dosisjustering anbefales under behandling med Zebinix hos patienter, voksne og børn over 6 år, med kreatininclearance <60 ml/min (se pkt.
English: 200 ml bottle oral syringe (10 ml) (outer pack only)
Danish: 200 ml flaske mundsprøjte (10 ml) (kun på den ydre emballage)
English: Xanthan gum (E415)
Danish: Xanthangummi (E145)
English: • Charcoal (dark) stool;
Danish: • kulfarvet (sort) afføring
English: Take special care with Zebinix:
Danish: Vær særlig forsigtig med at tage Zebinix:
English: Dosage should be increased in weekly or bi-weekly increments of 10 mg/kg/day up to 30 mg/kg/day,based on individual response.
Danish: Dosis bør øges med stigninger hver eller hver anden uge på 10 mg/kg/dag op til 30 mg/kg/dag baseret på individuel respons.
English: What you need to know before you take Zebinix Do not take Zebinix:
Danish: Det skal De vide, før De begynder at tage Zebinix Tag ikke Zebinix:
English: The efficacy of eslicarbazepine acetate as monotherapy has been demonstrated in a double-blind, active controlled (carbamazepine controlled release) study, involving 815 randomized adult patients with newly diagnosed partial-onset seizures.
Danish: Eslicarbazepinacetats virkning som monoterapi er påvist i et dobbeltblindt, aktivt kontrolleret (carbamazepin-depotformulering) studie med 815 randomiserede voksne patienter med nyligt diagnosticerede fokale epileptiske anfald.
English: The adverse reaction profile of eslicarbazepine acetate is generally similar across age goups.
Danish: Bivirkningsprofilen for eslicarbazepinacetat er generelt ens på tværs af aldersgrupper.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING Outer carton of multipacks (including blue box)
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Yderkarton for multipakninger (med blue box)
English: If you are taking Zebinix on its own your doctor may consider you can benefit of a dose of 1,600 mg once daily.
Danish: Hvis Zebinix er det eneste lægemiddel, De tager mod Deres epilepsi, vil lægen muligvis vurdere, at De kan have gavn af en dosis på 1.600 mg en gang dagligt.