FrancophonIA/ELRC3.0 huggingface dataset:
English: changes in liver enzymes and function, yellowing of the skin due to liver problems, liver tissue damage and inflammation of the liver rare:
Slovenian: spremembe v jetrnih encimih in delovanju jeter, porumenelost kože zaradi jetrnih motenj, okvara jetrnega tkiva in vnetje jeter redki:
English: In treatment of acute rejection the therapeutic regiment with tacrolimus has been proven to provide either a significantly improved histological endomyocardial biopsy grading of rejection or a resolution of rejection.
Slovenian: Dokazano je bilo, da shema zdravljenja s takrolimusom pri zdravljenju akutne zavrnitve bodisi bistveno zniža stopnjo zavrnitvene reakcije, ugotovljeno na podlagi histološke biopsije endomiokarda, bodisi odpravi zavrnitev.
English: Ventricular hypertrophy or hypertrophy of the septum, reported as cardiomyopathies, have been observed on rare occasions.
Slovenian: V redkih primerih so opažali ventrikularno hipertrofijo ali hipertrofijo septuma, opisani kot kardiomiopatije.
English: ileus paralytic, peritonitis, acute and chronic pancreatitis, blood amylase increased, gastrooesophageal reflux disease, impaired gastric emptying rare:
Slovenian: paralitični ileus, peritonitis, akutni in kronični pankreatitis, zvišanje amilaze v krvi, gastroezofagealna refluksna bolezen, okvarjeno praznjenje želodca redki:
English: Weaker interactions have been observed with clotrimazole, clarithromycin, josamycin, nifedipine, nicardipine, diltiazem, verapamil, danazol, ethinylestradiol, omeprazole and nefazodone.
Slovenian: Šibkejše interakcije so opažali s klotrimazolom, klaritromicinom, josamicinom, nifedipinom, nikardipinom, diltiazemom, verapamilom, danazolom, etinilestradiolom, omeprazolom in nefazodonom.
English: In clinical practice, whole blood trough levels have generally been in the range 5 - 20 ng/ml in liver transplant recipients and 10 - 20 ng/ml in kidney and heart transplant patients in the early posttransplant period.
Slovenian: V klinični praksi so bile najmanjše koncentracije v polni krvi v zgodnjem obdobju po presaditvi pri prejemnikih jeter na splošno od 5 do 20 ng/ml in pri prejemnikih ledvice ali srca od 10 do 20 ng/ml.
English: Using <Invented name> with food and drink Grapefruit and grapefruit juice should be avoided while using <Invented name>.
Slovenian: Uporaba zdravila <(Lastniško) ime zdravila> skupaj s hrano in pijačo Med uporabo zdravila <(Lastniško) ime zdravila> se morate izogibati uživanju grenivk in pitju grenivkinega soka .
English: HOW TO USE <INVENTED NAME>
Slovenian: <Izmišljeno ime> <Ime>
English: reduced magnesium, phosphate, potassium, calcium or sodium in the blood, fluid overload, increased uric acid or lipids in the blood, decreased appetite, increased acidity of the blood, other changes in the blood salts uncommon:
Slovenian: znižanje magnezija, fosfata, kalija, kalcija ali natrija v krvi, preobremenitev s tekočino, zvišanje sečne kisline ali maščob v krvi, zmanjšan apetit, povečana kislost krvi, druge spremembe elektrolitov v krvi občasni:
English: coma, bleeding in the brain, stroke, paralysis, brain disorder, speech and language abnormalities, memory problems rare:
Slovenian: koma, krvavitev v možgane, možganska kap, paraliza, bolezni možganov, nepravilnosti govora in jezika, težave s spominom redki:
English: Dosage recommendations - Rejection therapy, other allografts
Slovenian: Priporočila za odmerjanje - zdravljenje zavrnitve, drugi alotransplantati
English: serious illness with blistering of skin, mouth, eyes and genitals, increased hairiness Bone and joint disorders common:
Slovenian: resna bolezen z mehurji na koži, v ustih, na očeh in spolovilih, močnejša poraščenost Bolezni kosti in sklepov pogosti:
English: anxiety symptoms, confusion and disorientation, depression, mood changes, nightmare, hallucination, mental disorders
Slovenian: simptomi tesnobe, zmedenost in dezorientiranost, depresija, motnje razpoloženja, nočne more, halucinacije, duševne motnje
English: If in doubt please consult your doctor prior to taking any herbal products or remedies.
Slovenian: Če ste v dvomih, se pred uporabo kateregakoli izdelka ali zdravila rastlinskega izvora posvetujte z zdravnikom.
English: Metabolic interactions
Slovenian: Presnovne interakcije
English: hyperglycaemic conditions, diabetes mellitus, hyperkalaemia common:
Slovenian: hiperglikemična stanja, diabetes mellitus, hiperkaliemija pogosti:
English: The half-life of ciclosporin is prolonged when tacrolimus is given concomitantly.
Slovenian: Ob sočasni uporabi takrolimusa se razpolovni čas ciklosporina podaljša.
English: A lower incidence of acute rejection episodes for tacrolimus- versus ciclosporintreated patients (11.5% versus 22.6%) and a lower incidence of chronic rejection, the bronchiolitis obliterans syndrome (2.86% versus 8.57%), was reported within the first year after transplantation.
Slovenian: V prvem letu po presaditvi so imeli prejemniki takrolimusa manjšo incidenco akutnih zavrnitvenih epizod (11,5 %) in kronične zavrnitve, sindroma obliteracijskega bronhiolitisa (2,86 %), kot prejemniki ciklosporina, pri katerih sta bila ta deleža 22,6 % oz. 8,57 %.
English: - In view of the potential risk of malignant skin changes with immunosuppressive therapy, you should wear appropriate protective clothing and use a sunscreen with a high sun protection factor to limit your exposure to sunlight and UV light.
Slovenian: Da boste omejili izpostavljenost sončni svetlobi in ultravijoličnim žarkom, morate nositi ustrezna zaščitna oblačila in uporabljati sredstvo za sončenje z visokim zaščitnim faktorjem.
English: Increased <Invented name> doses, supplemental corticosteroid therapy, and introduction of short courses of mono-/polyclonal antibodies have all been used to manage rejection episodes.
Slovenian: Za obvladanje zavrnitvenih epizod so uporabljali večje odmerke <(Lastniško) ime zdravila>, dodatno zdravljenje s kortikosteroidi in uvedbo kratkih ciklusov mono-/poliklonskih protiteles.
English: How to store <Invented name> Further information
Slovenian: Shranjevanje zdravila <(Lastniško) ime zdravila> Dodatne informacije
English: As tacrolimus may reduce the clearance of steroid-based contraceptives leading to increased hormone exposure, particular care should be exercised when deciding upon contraceptive measures.
Slovenian: Takrolimus lahko zmanjša očistek steroidnih kontraceptivov in tako povzroči večjo izpostavljenost hormonom.
English: Grapefruit juice has been reported to increase the blood level of tacrolimus and should therefore be avoided.
Slovenian: Opisano je, da grenivkin sok zveča koncentracijo takrolimusa v krvi, zato se mu morajo bolniki izogibati.
English: Liver transplantation:
Slovenian: Presaditev ledvic:
English: difficulties in breathing, respiratory tract disorders, asthma rare:
Slovenian: težave z dihanjem, bolezni dihal, astma redki:
English: Blood and lymphatic system disorders common:
Slovenian: Bolezni krvi in limfatičnega sistema pogosti:
English: The use of ibuprofen, amphotericin B, antivirals (e.g. aciclovir), may worsen kidney or nervous system problems when taken together with <Invented name>.
Slovenian: Če so ibuprofen, amfotericin B ali protivirusna zdravila (npr. aciklovir) uporabljeni hkrati z <(Lastniško) ime zdravila>, lahko poslabšajo težave z ledvicami ali živčevjem.
English: Therefore you should not breast-feed whilst receiving <Invented name>.
Slovenian: Zato med prejemanjem zdravila <(Lastniško) ime zdravila> ne smete dojiti.
English: Dosage recommendations - Heart transplantation Prophylaxis of transplant rejection - adults <Invented name> can be used with antibody induction (allowing for delayed start of <Invented name> therapy) or alternatively in clinically stable patients without antibody induction.
Slovenian: Profilaksa zavrnitve presadka - odrasli <Invented name> je mogoče uporabiti z indukcijo protiteles (kar omogoča odlog začetka zdravljenja z <Invented name>), ali pa pri klinično stabilnih bolnikih brez indukcije protiteles.
English: blurred vision, increased sensitivity to light, eye disorders uncommon:
Slovenian: zamegljen vid, večja občutljivost za svetlobo, očesne bolezni občasni:
English: It is necessary to consider the clinical condition of the patient when interpreting whole blood levels.
Slovenian: Pri tolmačenju koncentracije v polni krvi je treba upoštevati bolnikovo klinično stanje.
English: The 1-year patient survival rate was 80.8% in the tacrolimus and 83% in the ciclosporin group (Treede et al., 3rd ICI San Diego, US, 2004;Abstract 22).
Slovenian: Enoletno preživetje bolnikov je bilo v skupini s takrolimusom 80,8 % in v skupini s ciklosporinom 83 % (Treede et al., 3rd
English: The ethanol content (638 mg per ml) of <Invented name> 5mg/ml Concentrate for Solution for Infusion should be taken into account.>
Slovenian: Upoštevati je treba vsebnost etanola (638 mg na ml) v koncentratu za raztopino za infundiranje <Lastniško ime> 5 mg/1 ml.>
English: fits, disturbances in consciousness, tingling and numbness (sometimes painful) in the hands and feet, dizziness, impaired writing ability, nervous system disorders uncommon:
Slovenian: napadi krčev, motnje zavesti, mravljinci in omrtvelost (včasih boleča) dlani in stopal, omotica, okrnjena zmožnost za pisanje, bolezni živčevja občasni:
English: Based on the documentation submitted by the MAH and the scientific discussion within the Committee, the CPMP considered that the benefit/risk ratio of Prograf and associated names is favourable for use relating to:
Slovenian: Na podlagi dokumentacije, ki jo je predložil imetnik dovoljenja za promet z zdravilom, ter znanstvene razprave znotraj Odbora je CHMP menil, da je razmerje med tveganji in koristmi za zdravilo Prograf in z njim povezana imena ugodno za uporabo pri: - profilaksi zavrnitve presadka pri prejemnikih alotransplantata jeter, ledvic ali srca; - zdravljenju zavrnitve alotransplantata, odporne proti terapiji z drugimi imunosupresivi.
English: Factors such as low haematocrit and protein levels, which result in an increase in the unbound fraction of tacrolimus, or corticosteroid-induced increased metabolism are considered to be responsible for the higher clearance rates observed following transplantation.
Slovenian: Za hitrejši očistek po presaditvi so verjetno odgovorni dejavniki, kot sta nizek hematokrit in majhna koncentracija beljakovin, zaradi česar se poveča delež nevezanega takrolimusa, in s kortikosteroidi izzvano povečanje presnove.
English: Belgium Fujisawa GmbH Neumarkter Str. 61
Slovenian: Luksemburg Fujisawa GmbH Neumarkter Str. 61
English: Concentrate for Solution for Infusion
Slovenian: Koncentrat za pripravo raztopine za infundiranje
English: inflammations or ulcers causing abdominal pain or diarrhoea, bleedings in the stomach, inflammations or ulcers in the mouth, collection of fluid in the belly, vomiting, abdominal pains, indigestion, constipation, flatulence, bloating, loose stools, stomach problems uncommon:
Slovenian: vnetje ali razjede, ki povzročajo bolečine v trebuhu ali drisko, krvavitev v želodec, vnetje ali razjede v ustih, nabiranje tekočine v trebuhu, bruhanje, bolečine v trebuhu, prebavne težave, zaprtje, vetrovi, napenjanje, mehko blato, težave z želodcem občasni:
English: Stopping your treatment with <Invented name> may increase the risk of rejection of your transplanted organ.
Slovenian: Če ste prenehali jemati <(Lastniško) ime zdravila> Prekinitev zdravljenja z <(Lastniško) ime zdravila> lahko poveča tveganje za zavrnitev presajenega organa.
English: <Invented name> must not be used with ciclosporin.
Slovenian: Zdravila <(Lastniško) ime zdravila> se ne sme uporabljati skupaj s ciklosporinom.
English: reduced blood flow in the heart vessels, faster heartbeat uncommon:
Slovenian: zmanjšan pretok krvi skozi srčne žile, hitrejši srčni utrip občasni:
English: Very rare side effects are experienced in less than one per ten thousand patients.
Slovenian: Zelo redki neželeni učinki se pojavijo pri manj kot enem od deset tisoč bolnikov.
English: dehydration, reduced protein or sugar in the blood, increased phosphate in the blood
Slovenian: dehidracija, znižanje beljakovin ali sladkorja v krvi, zvišanje fosfata v krvi Psihiatrične motnje zelo pogosti:
English: As the pharmacokinetics of tacrolimus are unaffected by renal function, no dose adjustment should be required.
Slovenian: Delovanje ledvic ne vpliva na farmakokinetiko takrolimusa, zato prilagoditev odmerka načeloma ni potrebna.
English: The initial oral per protocol dose of tacrolimus was 0.2 mg/kg/day with subsequent dose adjustments to target trough levels of 8 to 15 ng/ml by Day 5 and 5 to 10 ng/mL after Month 6.
Slovenian: Uvodni peroralni odmerek takrolimusa po protokolu je bil 0,2 mg/kg/dan z nadaljnjimi prilagoditvami odmerka tako, da je bila do 5. dne dosežena ciljna najmanjša koncentracija od 8 do 15 ng/ml in po 6. mesecu od 5 do 10 ng/ml.
English: Benign and malignant tumours have been reported following <Invented name> treatment as a result of immunosuppression.
Slovenian: Po zdravljenju z <(Lastniško) ime zdravila> name so poročali o benignih in malignih tumorjih kot posledici imunosupresije.
English: An initial oral dose of 0.30 mg/kg/day should be administered in two divided doses (e.g. morning and evening).
Slovenian: Začetni peroralni odmerek 0,30 mg/kg/dan je treba uporabiti v dveh deljenih odmerkih (npr. zjutraj in zvečer).
English: Heart disorders common:
Slovenian: Srčne bolezni pogosti:
English: coma, central nervous system haemorrhages and cerebrovascular accidents, paralysis and paresis, encephalopathy, speech and language abnormalities, amnesia rare:
Slovenian: koma, krvavitve v osrednje živčevje in cerebrovaskularni incidenti, paraliza in pareza, encefalopatija, nenormalnosti govora in jezika, amnezija redki:
English: The combined administration of ciclosporin and tacrolimus should be avoided and care should be taken when administering tacrolimus to patients who have previously received ciclosporin (see sections 4.2 and 4.5).
Slovenian: Kombinirani uporabi ciklosporina in takrolimusa se je treba izogniti; pri bolnikih, ki so prej dobivali ciklosporin, je treba takrolimus uporabiti previdno (glejte poglavji 4.2 in 4.5).
English: It is possible in some cases to withdraw concomitant immunosuppressive therapy, leading to <Invented name> monotherapy.
Slovenian: Včasih je mogoče sočasno imunosupresivno terapijo opustiti, kar pomeni prehod na monoterapijo s <(Lastniško) ime zdravila>.
English: Dose reduction may be necessary in patients with severe liver impairment in order to maintain the blood trough levels within the recommended target range.
Slovenian: Za ohranitev najmanjše koncentracije v krvi znotraj priporočenega ciljnega območja utegne biti pri bolnikih s hudo okvaro jeter potrebno zmanjšanje odmerka.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON 5 mg/ml CONCENTRATE FOR SOLUTION FOR INFUSION
Slovenian: PODATKI NA ZUNANJI OVOJNINI ŠKATLA 5 mg/ml KONCENTRAT ZA RAZTOPINO ZA INFUNDIRANJE
English: Prophylaxis of transplant rejection in liver, kidney or heart allograft recipients.
Slovenian: Profilaksa zavrnitve presadka pri prejemnikih alotransplantata jeter, ledvic ali srca.
English: Several cases of accidental overdosage have been reported; symptoms have included tremor, headache, nausea and vomiting, infections, urticaria, lethargy, increased blood urea nitrogen and elevated serum creatinine concentrations, and increase in alanine aminotransferase levels.
Slovenian: Med simptomi so bili tremor, glavobol, navzeja in bruhanje, okužbe, urtikarija, letargija, zvišanje sečnine v krvi, povečanje koncentracije kreatinina v serumu in zvišanje ravni alanin-aminotransferaze.
English: Prophylaxis of transplant rejection - children
Slovenian: Profilaksa zavrnitve presadka - otroci
English: Human data show that tacrolimus is able to cross the placenta.
Slovenian: Podatki pri ljudeh kažejo, da takrolimus prehaja skozi placento.
English: There are several metabolites identified.
Slovenian: Ugotovili so več presnovkov.
English: What <Invented name> is and what it is used for Before you use <Invented name> How to use <Invented name> Possible side effects
Slovenian: Kaj je zdravilo <(Lastniško) ime zdravila> in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo <(Lastniško) ime zdravila> Kako uporabljati zdravilo <(Lastniško) ime zdravila> Možni neželeni učinki
English: Allergic and anaphylactoid reactions have been observed in patients receiving tacrolimus (see section
Slovenian: Pri bolnikih, ki so dobivali takrolimus, so opisane alergijske in anafilaktoidne reakcije (glejte poglavje
English: PHARMACEUTICAL FORM AND CONTENTS [To be completed nationally]
Slovenian: FARMACEVTSKA OBLIKA IN VSEBINA [Izpolni država članica]
English: What <Invented name> is and what it is used for Before you take <Invented name> How to take <Invented name> Possible side effects
Slovenian: Kaj je zdravilo <(Lastniško) ime zdravila> in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo <(Lastniško) ime zdravila> Kako jemati zdravilo <(Lastniško) ime zdravila> Možni neželeni učinki
English: 0.075 - 0.30 mg per kg body weight per day depending on the transplanted organ.
Slovenian: Začetni odmerki tik po presaditvi so praviloma od 0,075 do 0,30 mg na kg telesne mase na dan, odvisno od presajenega organa.
English: thirst, fall, feeling of tightness in your chest, decreased mobility, ulcer very rare:
Slovenian: žeja, padec, občutek tiščanja v prsih, zmanjšana gibljivost, razjeda zelo redki:
English: For these reasons, the combined administration of ciclosporin and tacrolimus is not recommended and care should be taken when administering tacrolimus to patients who have previously received ciclosporin (see sections 4.2 and 4.4).
Slovenian: Zato kombinirana uporaba ciklosporina in takrolimusa ni priporočljiva; pri bolnikih, ki so prej dobivali ciklosporin, je treba takrolimus uporabiti previdno (glejte poglavji 4.2 in 4.4).
English: METHOD AND ROUTE(S) OF ADMINISTRATION Oral use.
Slovenian: POSTOPEK IN POT(I) UPORABE ZDRAVILA Peroralna uporaba.
English: tinnitus uncommon:
Slovenian: tinitus občasni:
English: irregular heartbeat, stop of heartbeat, reduced performance of your heart, disorder of the heart muscle, enlargement of the heart muscle, stronger heartbeat, abnormal ECG, heart rate and pulse abnormal rare:
Slovenian: nereden srčni utrip, zastoj srca, zmanjšana črpalna sposobnost srca, bolezen srčne mišice, povečanje srčne mišice, močnejši srčni utrip, nenormalen EKG, nenormalna hitrost bitja srca in srčni utrip redki:
English: Patients with kidney impairment
Slovenian: Bolniki z okvaro ledvic
English: Do not take <Invented name> - If you are allergic (hypersensitive) to tacrolimus or any of the other ingredients of <Invented name>.
Slovenian: Ne jemljite zdravila <(Lastniško) ime zdravila> - Če ste alergični na (preobčutljivi za) takrolimus ali katerokoli pomožno snov zdravila
English: deafness neurosensory very rare:
Slovenian: nevrosenzorična naglušnost zelo redki:
English: Benign as well as malignant neoplasms including EBV-associated lymphoproliferative disorders and skin malignancies have been reported in association with tacrolimus treatment.
Slovenian: V povezavi z zdravljenjem s takrolimusom so poročali o benignih in malignih neoplazmah, vključno z limfoproliferativnimi boleznimi, povezanimi z EBV, in kožnimi malignomi.
English: hirsutism
Slovenian: hirzutizem
English: anxiety symptoms, confusion and disorientation, depression, depressed mood, mood disorders and disturbances, nightmare, hallucination, mental disorders uncommon:
Slovenian: simptomi anksioznosti, zmedenost in dezorientiranost, depresija, potrtost, motnje razpoloženja, nočne more, halucinacije, duševne motnje občasni:
English: <Invented name> blood levels can be affected by other medicines you take, and blood levels of other medicines can be affected by taking <Invented name> which may require and increase or decrease in <Invented name> dose.
Slovenian: Druga zdravila, ki jih jemljete, lahko vplivajo na koncentracijo zdravila <(Lastniško) ime zdravila> v krvi, pa tudi jemanje zdravila <(Lastniško) ime zdravila> lahko vpliva na koncentracijo drugih zdravil v krvi, zato utegne biti potrebno povečanje ali zmanjšanje odmerka <(Lastniško) ime zdravila>.
English: Blood trough levels of tacrolimus should be monitored during the post-transplantation period.
Slovenian: V obdobju po presaditvi je treba nadzirati najmanjšo koncentracijo takrolimusa v krvi.
English: coagulopathies, coagulation and bleeding analyses abnormal, pancytopenia, neutropenia rare:
Slovenian: koagulopatije, nepravilnosti analiz koagulacije in krvavitve, pancitopenija, nevtropenija redki:
English: <Invented name> blood levels can be affected by other medicines you take, and blood levels of other medicines can be affected by using <Invented name> which may require and increase or decrease in <Invented name> dose.
Slovenian: Druga zdravila, ki jih jemljete, lahko vplivajo na koncentracijo zdravila <(Lastniško) ime zdravila> v krvi, pa tudi uporaba zdravila <(Lastniško) ime zdravila> lahko vpliva na koncentracijo drugih zdravil v krvi, zato utegne biti potrebno povečanje ali zmanjšanje odmerka <(Lastniško) ime zdravila>.
English: ventricular arrhythmias and cardiac arrest, heart failures, cardiomyopathies, ventricular hypertrophy, supraventricular arrhythmias, palpitations, ECG investigations abnormal, heart rate and pulse investigations abnormal rare:
Slovenian: ventrikularne aritmije in zastoji srca, srčno popuščanje, kardiomiopatije, hipertrofija prekatov, supraventrikularne aritmije, palpitacije, nepravilnosti na EKG, nepravilnosti srčne frekvence in ritma redki:
English: Your doctor will usually reduce your <Invented name> dose once your condition has stabilised.
Slovenian: Ko se bo vaše stanje ustalilo, bo zdravnik odmerek zdravila <(Lastniško) ime zdravila> ponavadi zmanjšal.
English: failure of some organs, influenza like illness, increased sensitivity to heat and cold, feeling of pressure on your chest, jittery or abnormal feeling, increase of the enzyme lactate dehydrogenase in your blood, weight loss rare:
Slovenian: odpoved nekaterih organov, gripi podobna bolezen, večja občutljivost za vročino in mraz, občutek pritiska v prsih, živčnost ali nenormalno počutje, povečanje encima laktat-dehidrogenaze v krvi, hujšanje redki:
English: BATCH NUMBER Batch: {number}
Slovenian: ŠTEVILKA SERIJE Serija: {številka}
English: It is possible in some cases to withdraw concomitant immunosuppressive therapy, leading to <Invented name>-based dualtherapy.
Slovenian: Včasih je mogoče sočasno imunosupresivno terapijo opustiti, kar pomeni prehod na dvojno terapijo s <(Lastniško) ime zdravila>.
English: Prograf and associated names (see Annex I) 0.5 mg hard capsules Prograf and associated names (see Annex I) 1 mg hard capsules Prograf and associated names (see Annex I) 5 mg hard capsules
Slovenian: Prograf in povezana imena (glejte Dodatek I) 0,5 mg trde kapsule Prograf in povezana imena (glejte Dodatek I) 1 mg trde kapsule Prograf in povezana imena (glejte Dodatek I) 5 mg trde kapsule
English: Astellas Pharma GmbH Neumarkter Str. 61 81673 München Germany
Slovenian: Astellas Pharma GmbH Neumarkter Str. 61 D-81673 München Nemčija
English: The medicinal product should only be prescribed, and changes in immunosuppressive therapy initiated, by physicians experienced in immunosuppressive therapy and the management of transplant patients.
Slovenian: Samo zdravniki, izkušeni v imunosupresivnem zdravljenju in vodenju bolnikov s presadki, smejo predpisovati to zdravilo in spreminjati imunosupresivno zdravljenje.
English: Tacrolimus has been shown to increase the blood level of phenytoin.
Slovenian: Dokazano je, da takrolimus zvišuje koncentracijo fenitoina v krvi.
English: Tacrolimus is a low-clearance substance.
Slovenian: Takrolimus je učinkovina z majhnim očistkom.
English: Very common side effects are experienced in more than one in ten patients.
Slovenian: Zelo pogosti neželeni učinki se pojavijo pri več kot enem od desetih bolnikov.
English: METHOD OF ADMINISTRATION Read the package leaflet before use.
Slovenian: POSTOPEK UPORABE Pred uporabo preberite priloženo navodilo.
English: EXP: {MM/YYYY}
Slovenian: Serija: {številka}