FrancophonIA/ELRC3.0 huggingface dataset:
English: In order to achieve a target concentration above the lower Cmin limit of 5 ng/ml, e.g. 8 ng/ml, the new everolimus dose would be 5 mg (an increase of 2.5 mg from the current daily dose).
Croatian: Da bi se postigla ciljana koncentracija iznad donje granice Cmin od 5 ng/ml, npr. 8 ng/ml, nova doza everolimusa bila bi 5 mg (povećanje od 2,5 mg u odnosu na sadašnju dnevnu dozu).
English: If the dose of your anti-seizure medicine changes, please inform your doctor.
Croatian: Ukoliko dođe do promjene doze Vašega antiepileptika, molimo da o tome obavijestite svoga liječnika.
English: Grade 2 (<75, ≥50x10
Croatian: Stupanj 2 (<75, ≥50x10
English: Once a stable dose is attained, trough concentrations should be monitored every 3 to 6 months in patients with changing body surface area, or every 6 to 12 months in patients with stable body surface area, for the duration of treatment.
Croatian: Nakon što se postigne stabilna doza, potrebno je za vrijeme trajanja liječenja pratiti najniže koncentracije lijeka svakih 3 do 6 mjeseci u bolesnika s promjenjivom površinom tijela ili svakih 6 do 12 mjeseci u bolesnika sa stabilnom površinom tijela.
English: The angiomyolipoma best overall response rate had increased to 58.0% (95% CI: 48.3, 67.3), with a rate of stable disease of 30.4% (Table 4).
Croatian: Najbolja ukupna stopa odgovora angiomiolipoma se povećala na 58,0% (95% CI: 48,3, 67,3), uz stopu stabilne bolesti od 30,4% (Tablica 4).
English: SEGA associated with TSC
Croatian: SEGA povezana s KTS-om
English: In patients with SEGA, the geometric mean Cmin values normalised to mg/m dose in patients aged <10 years and 10-18 years were lower by 54% and 40%, respectively, than those observed in adults (>18 years of age), suggesting that everolimus clearance was higher in younger patients.
Croatian: U bolesnika oboljelih od SEGA-e, geometrijske srednje vrijednosti Cmin normalizirane na dozu u mg/m u bolesnika mlađih od 10 godina i 10-18 godina bile su niže za 54% odnosno 40% od vrijednosti uočenih kod odraslih osoba (dob >18 godina), što upućuje na to da je klirens everolimusa veći kod mlađih bolesnika.
English: Everolimus appeared to spontaneously exacerbate background diseases (chronic myocarditis in rats, coxsackie virus infection of plasma and heart in monkeys, coccidian infestation of the gastrointestinal tract in minipigs, skin lesions in mice and monkeys).
Croatian: Čini se da everolimus spontano dovodi do egzacerbacije postojećih bolesti (kronični miokarditis u štakora, infekcije plazme i srca coxsackie-virusom u majmuna, infestacija kokcidijom probavnog sustava u patuljastih svinja, kožne lezije u miševa i majmuna).
English: 10 The patient must drink all of the oral suspension from the glass.
Croatian: Bolesnik mora popiti svu oralnu suspenziju iz čaše.
English: Stir the contents with the spoon to remove any medicine left on the glass and spoon.
Croatian: Promiješajte sadržaj žlicom da biste skinuli ostatke lijeka sa žlice i čaše.
English: Assess the everolimus trough level 2 weeks after discontinuation of one of multiple strong CYP3A4 inducers.
Croatian: Potrebno je odrediti najnižu razinu everolimusa 2 tjedna nakon prekida primjene jednog od više snažnih induktora CYP3A4.
English: Loss of either TSC1 or TSC2 leads to elevated rheb-GTP levels, a ras family GTPase, which interacts with the mTORC1 complex to cause its activation.
Croatian: Gubitak bilo TSC1, bilo TSC2, dovodi do povišene razine rheb-GTP, GTP-aze koja pripada ras obitelji proteina i ostvaruje međudjelovanje s mTORC1 kompleksom dovodeći do njegove aktivacije.
English: Monitoring of renal function, including measurement of blood urea nitrogen (BUN), urinary protein or serum creatinine, is recommended prior to the start of Votubia therapy and periodically thereafter.
Croatian: Preporučuje se praćenje funkcije bubrega, uključujući mjerenje dušika iz uree u krvi (BUN - engl. blood urea nitrogen), proteina u mokraći ili kreatinina u serumu, prije početka terapije Votubiom i redovito nakon toga.
English: The most common adverse reactions leading to discontinuation were pneumonitis (including interstitial lung disease), fatigue, dyspnoea, and stomatitis.
Croatian: Najčešće nuspojave koje su dovele do prekida primjene bile su pneumonitis (uključujući intersticijsku plućnu bolest), umor, dispneja i stomatitis.
English: In a male fertility study in rats, testicular morphology was affected at 0.5 mg/kg and above, and sperm motility, sperm head count, and plasma testosterone levels were diminished at 5 mg/kg, which is within the range of therapeutic exposure and which caused a reduction in male fertility.
Croatian: U ispitivanjima učinaka lijeka na plodnost mužjaka štakora, morfologija testisa bila je promijenjena pri primjeni doza od 0,5 mg/kg i višim, a do smanjenja motiliteta spermija, broja glavica spermija i razine testosterona u plazmi došlo je pri primjeni doze od 5 mg/kg, koje se nalaze u terapijskom rasponu izloženosti, te koje su izazvale smanjenje plodnosti mužjaka.
English: If a higher dose or number of tablets is required, an additional syringe must be prepared.
Croatian: Ako je potrebna veća doza ili broj tableta, pripremiti za to dodatnu štrcaljku.
English: Wash the glass and the spoon thoroughly with clean water.
Croatian: Temeljito operite čašu i žlicu čistom vodom.
English: In healthy subjects, high fat meals reduced systemic exposure to Votubia 10 mg tablets (as measured by AUC) by 22% and the peak blood concentration Cmax by 54%.
Croatian: U zdravih ispitanika, obroci s visokim sadržajem masti smanjili su sistemsku izloženost Votubia tabletama od 10 mg (mjerenu putem AUC-a) za 22%, a vršnu koncentraciju u krvi Cmax za 54%.
English: Problems with wound healing
Croatian: Poteškoće sa zacjeljivanjem rana
English: Food, however, had no apparent effect on the post absorption phase concentration-time profile 24 hours post-dose of either dosage form.
Croatian: Međutim, 24 sata nakon primjene bilo kojeg farmaceutskog oblika hrana nije imala nikakvoga vidljivoga učinka na profil koncentracije u ovisnosti o vremenu u fazi nakon apsorpcije lijeka.
English: If you have taken too much Votubia, or if someone else accidentally takes your tablets, see a doctor or go to a hospital immediately.
Croatian: Ako ste uzeli previše Votubie ili je netko drugi zabunom popio Vaše tablete, odmah se javite liječniku ili otiđite u bolnicu.
English: For paediatric patients who do not require immediate treatment, completion of the recommended childhood series of live virus vaccinations is advised prior to the start of therapy according to local treatment guidelines.
Croatian: Za pedijatrijske bolesnike kojima nije potrebno hitno liječenje, savjetuje se dovršetak preporučenog ciklusa cijepljenja živim cjepivima prije početka terapije u skladu s lokalnim smjernicama za liječenje.
English: The use of live vaccines should be avoided during treatment with Votubia (see section 4.5).
Croatian: Tijekom liječenja Votubiom mora se izbjegavati primjena živih cjepiva (vidjeti dio 4.5).
English: If Votubia is taken with orally administered CYP3A4 substrates with a narrow therapeutic index (e.g. pimozide, terfenadine, astemizole, cisapride, quinidine, ergot alkaloid derivatives or carbamazepine), the patient should be monitored for undesirable effects described in the product information of the orally administered CYP3A4 substrate (see section 4.5).
Croatian: Ako se Votubia uzima s peroralno primijenjenim CYP3A4 supstratima s uskim terapijskim indeksom (npr. pimozid, terfenadin, astemizol, cisaprid, kinidin, derivati ergot alkaloida ili karbamazepin), bolesnike je potrebno pratiti kako bi se uočile nuspojave opisane u informacijama o lijeku peroralno primijenjenih supstrata CYP3A4 (vidjeti dio 4.5).
English: Concomitant treatment of Votubia and potent inhibitors is not recommended.
Croatian: Istodobna primjena Votubie i potentnih inhibitora se ne preporučuje.
English: Everolimus trough concentrations should be assessed at least 1 week after the addition of a moderate CYP3A4 or PgP inhibitor.
Croatian: Najniže koncentracije everolimusa potrebno je odrediti najmanje 1 tjedan nakon uvođenja umjerenog inhibitora CYP3A4 ili PgP.
English: Adverse reactions are listed according to MedDRA system organ class.
Croatian: Nuspojave su navedene prema MedDRA klasifikaciji organskih sustava.
English: Response was defined as: ≥50% reduction in the sum of SEGA volume relative to baseline, plus no unequivocal worsening of non-target SEGA lesions, plus absence of new SEGA ≥1 cm in longest diameter, plus no new or worsening hydrocephalus Primary analysis for double blind period Final analysis includes patients who crossed over from the placebo group; median duration of exposure to everolimus of 204.9 weeks
Croatian: Odgovor je bio definiran kao: smanjenje od ≥50% u ukupnom volumenu SEGA-e u odnosu na početne vrijednosti, plus izostanak jasnog pogoršanja neciljanih lezija SEGA-e, plus odsutnost nove SEGA-e ≥1 cm u najduljem promjeru, plus izostanak novog ili pogoršanja postojećeg hidrocefalusa Primarna analiza za dvostruko slijepo razdoblje Završna analiza uključuje bolesnike koji su prešli iz placebo skupine; medijan trajanja izloženosti everolimusu bio je 204,9 tjedana
English: Patients with seizures receiving concomitant strong CYP3A4 inducers (e.g., enzyme inducing antiepileptics carbamazepine, phenobarbital, and phenytoin) at the start of treatment with everolimus require an increased starting dose to attain trough concentrations of 5 to 15 ng/ml (see Table 1).
Croatian: Bolesnicima s napadajima koji istodobno primaju snažne induktore CYP3A4 (npr. antiepileptike koji induciraju enzime karbamazepin, fenobarbital i fenitoin) na početku liječenja everolimusom potrebna je povećana početna doza da bi postigli najniže koncentracije od 5 do 15 ng/ml (vidjeti Tablicu 1).
English: Votubia dispersible tablets contain an active substance called everolimus.
Croatian: Votubia tablete za oralnu suspenziju sadrže djelatnu tvar zvanu everolimus.
English: A total of 366 patients were randomised in a 1:1.09:1 ratio to Votubia (n=117) low trough (LT) range (3 to 7 ng/ml), Votubia (n=130) high trough (HT) range (9 to 15 ng/ml) or placebo (n=119).
Croatian: Ukupno je 366 bolesnika bilo randomizirano u omjeru 1:1,09:1 na primanje Votubie (n=117) u donjem najnižem (DN) rasponu (3 do 7 ng/ml), Votubie (n=130) u gornjem najnižem (GN) rasponu (9 do 15 ng/ml) ili placeba (n=119).
English: However, inhibition of CYP3A4 and PgP in the gut cannot be excluded.
Croatian: Međutim, ne može se isključiti inhibicija CYP3A4 i PgP-a u crijevu.
English: Includes pneumocystis jirovecii (carinii) pneumonia (PJP, PCP)
Croatian: Pneumocystis jirovecii (carinii) (PJP, PCP)
English: These tumours are caused by a genetic disorder called tuberous sclerosis complex (TSC).
Croatian: Ove tumore uzrokuje urođeni poremećaj koji se naziva kompleks tuberozne skleroze (KTS).
English: 6 to <12 years n=37
Croatian: 6 do <12 godina n=37
English: Table 7 Change in primary SEGA volume over time
Croatian: Tablica 7 Promjena primarnoga volumena SEGA-e kroz vrijeme
English: HT target of 9-15 ng/ml
Croatian: GN ciljana vrijednost od 9-15 ng/ml
English: Baseline seizure frequency was a significant factor in the seizure response (with an odds ratio of 0.978 [95% CI: 0.959, 0.998]).
Croatian: Početna učestalost napadaja bila je značajan čimbenik u odgovoru s obzirom na napadaje (s omjerom izgleda od 0,978 [95% CI: 0,959; 0,998]).
English: Instructions for caregivers preparing the suspension using an oral syringe:
Croatian: Upute za njegovatelje koji pripremaju suspeziju korištenjem štrcaljke za usta:
English: The recommended starting dose for Votubia for the treatment of patients with SEGA is 4.5 mg/m 2.
Croatian: Preporučena početna doza Votubie za liječenje bolesnika sa SEGA-om je 4,5 mg/m
English: A single-arm study in postmenopausal breast cancer patients treated with Afinitor (everolimus) plus exemestane suggested that an alcohol-free corticosteroid oral solution, administered as a mouthwash during the initial 8 weeks of treatment, may decrease the incidence and severity of stomatitis (see section 5.1).
Croatian: Ispitivanje s jednom skupinom u postmenopauzalnih bolesnica s rakom dojke liječenih Afinitorom (everolimus) plus eksemestanom ukazalo je na to da bi bezalkoholna oralna otopina kortikosteroida, primijenjena kao otopina za ispiranje usta tijekom prvih 8 tjedana liječenja, mogla smanjiti incidenciju i težinu stomatitisa (vidjeti dio 5.1).
English: The primary efficacy endpoint was angiomyolipoma response rate based on independent central radiology review.
Croatian: Primarni ishod djelotvornosti bio je stopa odgovora angiomiolipoma na temelju neovisnog centralnog radiološkog očitanja.
English: For paediatric patients with SEGA who do not require immediate treatment, completion of the recommended childhood series of live virus vaccinations is advised prior to the start of therapy according to local treatment guidelines.
Croatian: Za pedijatrijske bolesnike sa SEGA-om kojima nije potrebno hitno liječenje, savjetuje se dovršetak preporučenog ciklusa cijepljenja živim cjepivima prije početka terapije u skladu s lokalnim smjernicama za liječenje.
English: 12 to <18 years n=26
Croatian: 12 do <18 godina n=26
English: Votubia tablets and Votubia dispersible tablets are not to be used interchangeably.
Croatian: Votubia tablete i Votubia tablete za oralnu suspenziju ne smiju se međusobno zamjenjivati.
English: 94.0% had skin lesions at baseline and 37.6% had target renal angiomyolipoma lesions (at least one angiomyolipoma ≥1 cm in longest diameter).
Croatian: 94,0% imalo je kožne lezije pri određivanju početnih vrijednosti, a 37,6% imalo je ciljane lezije angiomiolipoma bubrega (barem jedan angiomiolipom od ≥1 cm u najduljem promjeru).
English: Pull the plunger slowly down to draw in air until it is at the 9 ml mark on the syringe.
Croatian: Povucite klip lagano prema dolje da biste uvukli zrak sve dok klip ne dođe do oznake od 9 ml na štrcaljki.
English: It contains an active substance called everolimus which may reduce the size of kidney tumours called renal angiomyolipomas and brain tumours called subependymal giant cell astrocytomas (SEGA).
Croatian: Sadrži djelatnu tvar koja se zove everolimus, i koja može smanjiti veličinu tumora bubrega koji se zovu angiomiolipomi bubrega i tumora mozga koji se zovu subependimalni astrocitomi orijaških stanica (SEGA; engl.
English: Following oral administration, everolimus is the main circulating component in human blood.
Croatian: Nakon peroralne primjene lijeka, glavnu cirkulirajuću komponentu u krvi ljudi predstavlja everolimus.
English: Put the tip of the syringe into the water.
Croatian: Uronite vrh štrcaljke u vodu.
English: During the double-blind period, reduction of SEGA volume was evident within the initial 12 weeks of Votubia treatment: 29.7% (22/74) of patients had ≥50% reductions in volume and 73.0% (54/74) had ≥30% reductions in volume.
Croatian: Tijekom dvostruko slijepog razdoblja, smanjenje volumena SEGA-e zabilježeno je unutar prvih 12 tjedana liječenja Votubiom: 29,7% (22/74) bolesnika imalo je smanjenja volumena od ≥50%, a 73,0% (54/74) bolesnika imalo je smanjenja volumena od ≥30%.
English: Response was defined as: ≥50% reduction in the sum of angiomyolipoma volume relative to baseline, plus absence of new angiomyolipoma ≥1.0 cm in longest diameter, plus no increase in renal volume >20% from nadir, plus absence of grade ≥2 angiomyolipoma-related bleeding.
Croatian: Odgovor je bio definiran kao: smanjenje ≥50% u zbroju volumena angiomiolipoma u odnosu na početnu vrijednost, plus odsutnost novog angiomiolipoma veličine ≥1,0 cm u najduljem promjeru, plus bez povećanja u volumenu bubrega >20% od najniže vrijednosti, plus odsutnost krvarenja stupnja ≥2 povezanog s angiomiolipomom.
English: When switching pharmaceutical forms, the dose should be adjusted to the closest milligram strength of the new pharmaceutical form and the everolimus trough concentration should be assessed at least 1 week later (see section “Therapeutic drug monitoring” above).
Croatian: Pri prelasku s jednog farmaceutskog oblika na drugi, dozu je potrebno prilagoditi na najbližu jačinu u miligramima novog farmaceutskog oblika te odrediti najnižu koncentraciju everolimusa najmanje 1 tjedan kasnije (vidjeti dio „Praćenje koncentracije lijeka tijekom terapije” gore u tekstu).
English: Serious cases of haemorrhage, some with a fatal outcome, have been reported in patients treated with everolimus in the oncology setting.
Croatian: Ozbiljni slučajevi krvarenja, od kojih su neki imali smrtni ishod, prijavljeni su u bolesnika s onkološkim bolestima liječenih everolimusom.
English: Blood tests will also be carried out to check your kidney function (levels of creatinine, blood urea nitrogen or urinary protein), liver function (level of transaminases) and your blood sugar and lipid levels.
Croatian: Krvne pretrage bit će učinjene i u cilju provjere funkcije Vaših bubrega (određivanjem razine kreatinina, uree u krvi ili bjelančevina u mokraći) i funkcije Vaše jetre (određivanjem razine transaminaza) te provjere razina šećera i masnoća u Vašoj krvi.
English: Push the plunger up slowly to remove most of the air.
Croatian: Potisnite klip prema gore da biste izbacili većinu zraka.
English: Menstruation disorders such as absence of periods (amenorrhoea) or irregular periods Sore throat (pharyngitis)
Croatian: Menstrualni poremećaji kao što su izostanak menstruacije (amenoreja) ili neredovite mjesečnice Grlobolja (faringitis)
English: For patients with TSC who have SEGA and patients with TSC and refractory seizures, once a stable dose is attained, trough concentrations should be monitored every 3 to 6 months in patients with changing body surface area, or every 6 to 12 months in patients with stable body surface area, for the duration of treatment.
Croatian: Za bolesnike s KTS-om koji imaju SEGA-u i bolesnike s KTS-om i refraktornim napadajima, nakon što se postigne stabilna doza, potrebno je za vrijeme trajanja liječenja pratiti najniže koncentracije lijeka svakih 3 do 6 mjeseci u bolesnika s promjenjivom površinom tijela ili svakih 6 do 12 mjeseci u bolesnika sa stabilnom površinom tijela.
English: In clinical studies and post-marketing spontaneous reports, everolimus has been associated with renal failure events (including fatal outcome), proteinuria and increased serum creatinine.
Croatian: U kliničkim ispitivanjima i spontanim prijavama nakon stavljanja lijeka u promet everolimus je bio povezan s događajima zatajenja bubrega (uključujući smrtni ishod), proteinurije i povišenog kreatinina u serumu.
English: Taking the medicine
Croatian: Uzimanje lijeka
English: Hence everolimus may affect the bioavailability of orally co-administered CYP3A4 substrates.
Croatian: Dakle, everolimus može utjecati na bioraspoloživost istodobno peroralno primijenjenih supstrata CYP3A4.
English: The robustness and consistency of the primary analysis were supported by the: change in primary SEGA volume as per local investigator assessment (p<0.001), with 75.0% and 39.3% of patients experiencing reductions of ≥30% and ≥50%, respectively change in total SEGA volume as per independent central review (p<0.001) or local investigator assessment (p<0.001).
Croatian: Robustnost i dosljednost primarne analize bili su potkrijepljeni: promjenom u primarnom volumenu SEGA-e prema procjeni lokalnog ispitivača (p<0,001), pri čemu je u 75,0% bolesnika došlo do smanjenja ≥30%, a u 39,3% bolesnika došlo je do smanjenja ≥50% promjenom u ukupnom volumenu SEGA-e prema neovisnom centralnom očitanju (p<0,001) ili prema procjeni lokalnog ispitivača (p<0,001).
English: You should not breast-feed during treatment and for 2 weeks after the last dose of Votubia.
Croatian: Tijekom liječenja i još 2 tjedna nakon posljednje doze Votubie ne smijete dojiti.
English: Votubia will only be prescribed by a doctor with experience in treating patients with SEGA or seizures and with access to blood tests which will measure how much Votubia is in your blood.
Croatian: Votubiu će propisati samo liječnik s iskustvom u liječenju oboljelih od SEGA-e ili napadaja te koji ima dostupne krvne pretrage koje mjere količinu Votubie u Vašoj krvi.
English: With the possible exception of the rat-specific lens finding (where young animals appeared to be more susceptible), it appears that there is no significant difference in the sensitivity of juvenile animals to the adverse reactions of everolimus as compared to adult animals.
Croatian: Uz mogući izuzetak promjena na leći, specifično uočenih u štakora (čija se mladunčad doimala podložnijom ovoj promjeni), razlika u osjetljivosti mladunčadi na tretman everolimusom u odnosu na odrasle životinje nije bilo.
English: Table 3 Effects of other active substances on everolimus
Croatian: Tablica 3 Učinci drugih djelatnih tvari na everolimus
English: Everolimus is a potent inhibitor of the growth and proliferation of tumour cells, endothelial cells, fibroblasts and blood-vessel-associated smooth muscle cells and has been shown to reduce glycolysis in solid tumours in vitro and in vivo.
Croatian: Everolimus je potentni inhibitor rasta i proliferacije tumorskih stanica, endotelnih stanica, fibroblasta i glatkih mišićnih stanica u krvnim žilama te je in vitro i in vivo pokazano da smanjuje glikolizu u solidnim tumorima.
English: In patients with advanced solid tumours, peak everolimus concentrations (Cmax) are reached at a median time of 1 hour after daily administration of 5 and 10 mg everolimus under fasting conditions or with a light fat-free snack.
Croatian: U bolesnika s uznapredovalim solidnim tumorima, vršne koncentracije (Cmax) everolimusa dosežu se u medijanu vremena od jednog sata nakon primjene dnevne doze od 5 i 10 mg everolimusa, uzete natašte ili uz lagani bezmasni obrok.
English: • A dose-dependent brain penetration of everolimus, which is consistent with the hypothesis of saturation of an efflux pump present in the brain capillary endothelial cells.
Croatian: • na prodiranje everolimusa u mozak ovisno o dozi, što je sukladno pretpostavci o zasićenju efluks pumpe prisutne u endotelnim stanicama moždanih kapilara
English: The proportion of patients achieving at least 50% reductions in SEGA volume was 45.9% (45/98) and 62.1% (41/66) at weeks 96 and 192 after start of everolimus treatment.
Croatian: Udio bolesnika koji su postigli smanjenja volumena SEGA-e od najmanje 50% bio je 45,9% (45/98) odnosno 62,1% (41/66) 96 odnosno 192 tjedna nakon početka liječenja everolimusom.
English: Table 2 Effects of other active substances on everolimus
Croatian: Tablica 2 Učinci drugih djelatnih tvari na everolimus
English: Avoid the use of concomitant potent CYP3A4 inducers.
Croatian: Potrebno je izbjegavati istodobnu primjenu potentnih induktora CYP3A4.
English: If you have taken too much Votubia, or if someone else accidentally takes your dispersible tablets, see a doctor or go to a hospital immediately.
Croatian: Ako ste uzeli previše Votubie ili je netko drugi zabunom popio Vaše tablete za oralnu suspenziju, odmah se javite liječniku ili otiđite u bolnicu.
English: Additional adverse reactions of relevance observed in oncology clinical studies and post-marketing spontaneous reports, were cardiac failure, pulmonary embolism, deep vein thrombosis, impaired wound healing and hyperglycaemia.
Croatian: Dodatne značajne nuspojave uočene u onkološkim kliničkim ispitivanjima i spontanim prijavama nakon stavljanja lijeka u promet bile su zatajenje srca, plućna embolija, duboka venska tromboza, odgođeno zacjeljivanje rana i hiperglikemija.
English: Hence, everolimus is considered to contribute the majority of the overall pharmacological activity.
Croatian: Stoga se smatra da je veći dio ukupne farmakološke aktivnosti lijeka pripisiv everolimusu.
English: Other studies
Croatian: Ostala ispitivanja
English: Similarly, the proportion of patients achieving at least 30% reductions in SEGA volume was 71.4% (70/98) and 77.3% (51/66) at weeks 96 and 192 after start of everolimus treatment.
Croatian: Slično tome, udio bolesnika koji su postigli smanjenja volumena SEGA-e od najmanje 30% bio je 71,4% (70/98) odnosno 77,3% (51/66) 96 odnosno 192 tjedna nakon početka liječenja everolimusom.