FrancophonIA/ELRC3.0 huggingface dataset:
English: The product information may be subsequently updated by the Member State competent authorities, in liaison with the reference Member State, as appropriate, in accordance with the procedures laid down in Chapter 4 of Title III of Directive 2001/83/EC.
Maltese: L-informazzjoni tal-prodott tista' tiġi aġġornata sussegwentement mill-awtoritajiet kompetenti talIstati Membri, flimkien mal-Istat Membru ta' Referenza, kif xieraq, b'konformità mal-proċeduri stabbiliti f'Kapitlu 4 ta' Titolu III ta' Direttiva 2001/83/KE.
English: In clinical studies in which VEPESID and associated names was administered as a single agent either orally or by injection the most frequent adverse reactions of any severity were leucopenia (60 to 91%), thrombocytopenia (22 to 41%), nausea and/or vomiting (31 to 43%), and alopecia (8 to 66%).
Maltese: Fi studji kliniċi li fihom VEPESID u ismijiet assoċjati ingħataw bħala sustanza waħidha, jew b'mod orali jew permezz ta' injezzjoni, l-aktar reazzjonijiet avversi frekwenti ta' kwalunkwe gravità kienu lewkopenija (60 sa 91%), tromboċitopenija (22 sa 41%), dardir u/jew rimettar (31 sa 43%), u alopeċja (8 sa 66%).
English: Metabolic Complications
Maltese: Kumplikazzjonijiet Metaboliċi
English: Cross resistance between anthracyclines and etoposide has been reported in preclinical experiments.
Maltese: Reżistenza inkroċjata bejn anthracyclines u etoposide ġiet irrappurtat f'esperimenti prekliniċi.
English: Treatment is symptomatic.
Maltese: Il-kura hi sintomatika.
English: Date
Maltese: LISTA
English: Gastrointestinal disorders very common abdominal pain, anorexia, constipation,
Maltese: Disturbi gastro-intestinali komuni ħafna uġigħ addominali, anoressija, stitikezza,
English: On intravenous administration, the disposition of etoposide is best described as a biphasic process with a distribution half-life of about 1.5 hours and terminal elimination half-life ranging from 4 to 11 hours.
Maltese: Wara l-għoti ġol-vini, id-dispożizzjoni ta' etoposide tiġi deskritta aħjar bħala proċess bifażiku b'half life tad-distribuzzjoni ta' madwar 1.5 sigħat, u half-life ta' eliminazzjoni terminali li tvarja minn 4 sa 11-il siegħa.
English: Phenylbutazone, sodium salicylate, and aspirin may displace etoposide from plasma protein binding.
Maltese: Phenylbutazone, sodium salicylate, u aspirina jistgħu jispostaw etoposide mit-twaħħil tal-proteina tal-plażma.
English: Pharmacotherapeutic group: Cytostatics, plant alkaloids and other natural products, podophyllotoxin derivatives, ATC code: L01CB01
Maltese: Ċitostatiċi, alkalojdi tal-pjanti u prodotti naturali oħra, derivattivi ta' podophyllotoxin, Kodiċi ATC:
English: The oral bioavailability is variable but averages 76% at the 100 mg oral dose and 48% at the 400 mg oral dose.
Maltese: Il-bijodisponibilità orali hi varjabbli, iżda bħala medja hi ta' 76% fid-doża orali ta' 100 mg, u 48% bid-doża orali ta' 400 mg.
English: High dose ciclosporin, resulting in plasma concentrations above 2000 ng/mL, administered with oral etoposide has led to an 80% increase in etoposide exposure (AUC) with a 38% decrease in total body clearance of etoposide compared to etoposide alone.
Maltese: Doża għolja ta' ciclosporin, li tirriżulta f'konċentrazzjonijiet fil-plażma ta' aktar minn 2000 ng/mL, mogħti flimkien ma' etoposide orali, wassal għal żieda ta' 80% fl-esponiment ta' etoposide (AUC), bi tnaqqis ta' 38% fit-tneħħija globali ta' etoposide mill-ġisem meta mqabbel ma' etoposide waħdu.
English: Tumour lysis syndrome
Maltese: Sindrome tal-lisi tat-tumur
English: A specific antidote is not available.
Maltese: Antidot speċifiku mhuwiex disponibbli.
English: Neutropenia and thrombocytopenia
Maltese: Newtropenija u tromboċitopenija
English: Carcinogenic potential
Maltese: Potenzjal karċinoġeniku
English: At decreased creatinine clearance of 15 to 50 mL/min a dose reduction by 25% is recommended.
Maltese: Fil-livell ta' tnaqqis fit-tneħħija tal-kreatinina ta' 15-50 mL/min, hu rakkomandat tnaqqis fid-doża ta' 25%.
English: Not known (frequency cannot be estimated from the available data)
Maltese: Mhux magħrufa (il-frekwenza ma tistax tiġi stmata mill-informazzjoni disponibbli)
English: • dizziness
Maltese: • dijarea
English: The mean volumes of distribution at steady state fall in the range of 18 to 29 liters or 7 to 17 L/m2.
Maltese: Il-volumi medji tad-distribuzzjoni fl-istat fiss jaqgħu fil-medda ta' 18 sa 29 litru jew 7 sa 17 L/m2.
English: Etoposide shows low penetration into the CSF.
Maltese: Etoposide juri penetrazzjoni baxxa fis-CSF.
English: • 1.22 mg of sodium ethyl parahydroxybenzoate (E215) and
Maltese: • 1.22 mg ta' sodium ethyl parahydroxybenzoate (E215) and
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Blister strip 50mg and 100mg
Maltese: Srrixxa bil-folji 50 mg u 100 mg
English: Total doses of 2.4 g/m2 to 3.5 g/m2 administered intravenously over three days have resulted in severe mucositis and myelotoxicity.
Maltese: Dożi totali ta' 2.4 g/m2 sa 3.5 g/m2 mogħtija ġol-vini fuq perjodu ta' tlett ijiem, irriżultaw f'mukożite severa u majelotossiċità.
English: Interaction studies have only been performed in adults.
Maltese: Popolazzjoni pedjatrika Studji ta' interazzjoni twettqu biss f'adulti.
English: Nervous system disorders common dizziness uncommon neuropathy peripheral rare cortical blindness transient, neurotoxicities (e.g., somnolence and fatigue), optic neuritis, seizure**
Maltese: Disturbi fis-sistema nervuża komuni sturdament mhux komuni newropatija periferali rari għama kortikali temporanju, newrotossiċitajiet (eż. , ngħas u għeja), newrite ottika, aċċessjonijiet**
English: Capsule shell
Maltese: Qoxra tal-kapsula
English: Total body clearance values range from 33 to 48 mL/min or 16 to 36 mL/min/m2 and, like the terminal elimination half-life, are independent of dose over a range 100 to 600 mg/m2.
Maltese: Il-valuri totali tat-tneħħija mill-ġisem tvarjaw minn 33 sa 48 mL/min jew 16 sa 36 mL/min/m2 u, bħall-half-life tal-eliminazzjoni terminali, huma indipendenti mid-doża fuq firxa ta' 100 sa 600 mg/m2.
English: • 0.93 mg of sodium ethyl parahydroxybenzoate (E215) and
Maltese: • 0.93 mg ta' sodium ethyl parahydroxybenzoate (E215) and
English: Total body clearance and the terminal elimination half-life are independent of dose over a range 100 to 600 mg/m2.
Maltese: It-tneħħija totali mill-ġisem u l-half-life ta' eliminazzjoni terminali huma indipendenti mid-doża fuq firxa 100-600 mg/m2.
English: The mean renal clearance of etoposide is 7 to 10 mL/min/m2 or about 35% of the total body clearance over a dose range of 80 to 600 mg/m2.
Maltese: etoposide mill-kliewi hi ta' 7 sa 10 mL/min/m2 jew madwar 35% tat-tneħħija totali mill-ġisem fuq medda ta' doża ta' 80 sa 600 mg/m2.
English: An 11q23 chromosome abnormality has been observed in some cases of secondary leukaemia in patients who have received epipodophyllotoxins.
Maltese: Anormalità fi kromożom 11q23 ġiet osservata f'xi każijiet ta' lewkimja sekondarja f'pazjenti li jkunu rċivew epipodophyllotoxins.
English: Myelosuppression
Maltese: Mutaġeneċità
English: • 0.61 mg of sodium propyl parahydroxybenzoate (E217).
Maltese: • 0.61 mg ta' sodium propyl parahydroxybenzoate (E217).
English: The usual dose is 100 to 200 mg/m2 body surface area, daily for 5 days in a row or 200 mg/m2 body surface area on days 1, 3
Maltese: Id-doża normali hi ta' 100 sa 200 mg/m2 tas-superfiċje tal-ġisem, kuljum għal 5 ijiem wara xulxin, jew 200 mg/m2 tas-superfiċje tal-ġisem f'jiem 1, 3 u 5.
English: • infection
Maltese: • infezzjoni
English: • 0.47 mg of sodium propyl parahydroxybenzoate (E217).
Maltese: • 0.47 mg ta' sodium propyl parahydroxybenzoate (E217).
English: - The other ingredients are: citric acid, anhydrous (E330), glycerol (85 per cent) (E422), macrogol 400 (E1521) and water.
Maltese: - Is-sustanzi l-oħra huma: citric acid, anhydrous (E330), glycerol (85 fil-mja) (E422), macrogol 400
English: In vitro plasma protein binding is 97%.
Maltese: It-twaħħil tal-proteini mal-plażma in vitro hu ta' 97%.
English: In case of curative intent the intravenous formulation should be used (see section 5.2).
Maltese: Fil-każ ta' intenzjoni kurattiva, il formulazzjoni ġol-vini għandha tintuża (ara sezzjoni 5.2).
English: Leucopenia and severe leucopenia (less than 1,000 cells/mm 91% and 3 to 17%, respectively, for etoposide.
Maltese: ċellula/mm3) kienu osservati f'60 sa 91% u fi 3 sa 17%, rispettivament, għal etoposide.
English: Reproductive system and breast disorders not known infertility
Maltese: Disturbi fis-sistema riproduttiva u fis-sider mhux magħruf infertilità
English: Reversible alopecia, sometimes progressing to total baldness, was observed in up to 66% of patients treated with etoposide.
Maltese: Alopeċja riversibbli, li xi kultant tiggrava għal twaqqigħ tax-xagħar totali, ġiet osservata f'sa 66% tal pazjenti kkurati b'etoposide.
English: common acute leukaemia
Maltese: komuni lewkimja akuta
English: Live vaccines are contraindicated in immunosuppressed patients (see section 4.3).
Maltese: Tilqim ħaj hu kontraindikat f'pazjenti immunosoppressi (ara sezzjoni 4.3).
English: testicular cancer small cell lung cancer cancer of the blood (acute myeloid leukaemia) tumour in the lymphatic system (Hodgkin's lymphoma, non-Hodgkin's lymphoma) ovarian cancer
Maltese: - kanċer tad-demm (lewkimja majelojde akuta) - tumur fis-sistema limfatika (limfoma ta' Hodgkin, limfoma mhux ta' Hodgkin)
English: Low serum albumin
Maltese: Albumina baxxa fis-serum
English: VEPESID and associated names contains sodium ethyl parahydroxybenzoate and sodium propyl parahydroxybenzoate
Maltese: VEPESID u ismijiet assoċjati fihom sodium ethyl parahydroxybenzoate u sodium propyl parahydroxybenzoate
English: Etoposide binding ratio correlates directly with serum albumin in cancer patients and normal volunteers (see section 4.4).
Maltese: Il-proporzjon tat-twaħħil ta' etoposide jikkorrela direttament mal-albumina fis-serum f'pazjenti bil kanċer u f'voluntiera normali (ara sezzjoni 4.4).
English: • tingling or numbness in hands and feet Rare side effects (affecting between 1 in 1,000 and 1 in 10,000 people)
Maltese: • tnemnim jew tmewwit fl-idejn u fis-saqajn Effetti sekondarji rari (li jaffettwaw bejn 1 u 1,000 u 1 minn kull 10,000 persuna)
English: VEPESID capsules are opaque pink, soft gelatin capsules.
Maltese: Il-kapsuli VEPESID huma kapsuli rotob tal-ġelatina, roża u opaki.
English: As etoposide may decrease male fertility, preservation of sperm may be considered for the purpose of later fatherhood (see section 4.6).
Maltese: Billi etoposide jista' jnaqqas il-fertilità maskili, il-preservazzjoni tal-isperma tista' tiġi kkunsidrata għalliskop ta' paternità aktar tard (ara sezzjoni 4.6).
English: The usual dose of VEPESID and associated names administered orally is 100 to 200 mg/m2/day on days 1 to 5 or 200 mg/m2/day on days 1, 3 and 5 every 3 to 4 weeks.
Maltese: Id-doża tas-soltu ta' VEPESID u ismijiet assoċjati mogħtija b'mod orali hija 100 sa 200 mg/m2/jum f'jiem 1 sa 5 jew 200 mg/m2/jum f'jiem 1, 3 u 5 kull 3 sa 4 ġimgħat.
English: Contains sodium ethyl parahydroxybenzoate and sodium propyl parahydroxybenzoate (see leaflet for further information).
Maltese: Fih sodium ethyl parahydroxybenzoate u sodium propyl parahydroxybenzoate (ara l-fuljett għal aktar informazzjoni).
English: Hepatobiliary disorders very common hepatotoxicity not known alanine aminotransferase increased, alkaline phosphatase increased, aspartate amino transferase increased, bilirubin increased
Maltese: Disturbi fil-fwied u fil-marrara komuni ħafna epatotossiċità mhux magħruf żieda f'alanine aminotransferase, żieda f'alkaline phosphatase, żieda f'amino aspartate transferase, żieda fil-bilirubina
English: Etoposide and its metabolites are not dialyzable.
Maltese: Etoposide u l-metaboliti tiegħu mhumiex dijalizzabbli.
English: Although minor differences in pharmacokinetic parameters between patients ≤65 years and >65 years of age have been observed, these are not considered clinically significant.
Maltese: Għalkemm differenzi minuri fil-parametri farmakokinetiċi bejn pazjenti ta' ≤65 sena u >65 sena ġew osservati, dawn mhumiex ikkunsidrati li huma klinikament sinifikanti.
English: • acid reflux
Maltese: • rifluss tal-aċidu
English: QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains 50 mg etoposide
Maltese: Kull kapsula fiha etoposide 50 mg jew
English: Anaemia, leucopenia, and thrombocytopenia were observed in rats and mice, while dogs had mild reversible deterioration of liver and kidney functions.
Maltese: Anemija, lewkopenija, u tromboċitopenija ġew osservati fil-firien u ġrieden, filwaqt li l-klieb kellhom deterjorament riversibbli ħafif tal-funzjonijiet tal-fwied u tal-kliewi.
English: VEPESID and associated names contains sodium ethyl parahydroxybenzoate and sodium propyl parahydroxybenzoate.
Maltese: VEPESID u ismijiet assoċjati fihom sodium ethyl parahydroxybenzoate u sodium propyl parahydroxybenzoate.
English: The usual dose of VEPESID and associated names administered orally is 100 to 200 mg/m2/day on days 1 to 5 or 200 mg/m2/day on days 1, 3 and 5 every 3 to 4 weeks in combination with other drugs approved for use in the disease to be treated.
Maltese: Id-doża tas-soltu ta' VEPESID u ismijiet assoċjati mogħtija b'mod orali hija 100 sa 200 mg/m2/jum f'jiem 1 sa 5 jew 200 mg/m2/jum f'jiem 1, 3 u 5 kull 3 sa 4 ġimgħat flimkien ma' mediċini oħrajn approvati għall-użu fil-marda li tkun se tiġi kkurata.
English: Two dose-dependent responses are seen: At high concentrations (10 mcg/mL or more), cells entering mitosis are lysed; at low concentrations (0.3 to 10 mcg/mL), cells are inhibited from entering prophase.
Maltese: Żewġ risponsi dipendenti mid-doża jiġu osservati: F'konċentrazzjonijiet għoljin (10 mcg/mL jew aktar), iċ-ċelluli li jidħlu fil-mitożi jiġu lysed; f'konċentrazzjonijiet baxxi (0.3 sa 10 mcg/mL), iċ-ċelluli jiġu inibiti milli jidħlu fil-profażi.
English: • abdominal pain
Maltese: • diffikultà biex tibla'
English: In a study of the effects of other therapeutic agents on in vitro binding of 14C etoposide to human serum proteins, only phenylbutazone, sodium salicylate, and aspirin displaced protein-bound etoposide at concentrations generally achieved in vivo (see section 4.5).
Maltese: Fi studju dwar l-effetti ta' sustanzi terapewtiċi oħra fuq it-twaħħil in vitro ta' 14C etoposide mal proteini tas-serum tal-bniedem, phenylbutazone, sodium salicylate, u l-aspirina biss spostaw etoposide imwaħħal mal-proteini f'konċentrazzjonijiet ġeneralment miksuba in vivo (ara sezzjoni 4.5).
English: Blood and lymphatic system disorders very common anaemia , leucopenia, myelosuppression*, neutropenia, thrombocytopenia
Maltese: Disturbi tad-demm u tas-sistema limfatika komuni ħafna anemija, lewkopenija, majelosoppressjoni*, newtropenija,
English: An alternative dosage schedule for VEPESID and associated names capsules is 50 mg/m2/day for 2 to 3 weeks, with courses repeated after a one week rest period or upon recovery from myelosuppression.
Maltese: Skeda ta' dożaġġ alternattiv għall-kapsuli VEPESID u ismijiet assoċjati hi ta' 50 mg/m2/jum għal 2 sa 3 ġimgħat, b'korsijiet ripetuti wara perjodu ta' mistrieħ ta' ġimgħa waħda, jew meta jseħħ l-irkupru minn majelosoppressjoni.
English: Each 100 mg capsule, soft contains:
Maltese: Kull kapsula ratba ta' 100 mg fiha:
English: Patients with impaired renal function receiving etoposide have exhibited reduced total body clearance, increased AUC and higher steady state volume of distribution (see section 4.2).
Maltese: Pazjenti b'indeboliment fil-funzjoni tal-kliewi li kienu qed jirċievu etoposide, urew tnaqqis fittneħħija totali mill-ġisem, żieda fl-AUC u volum ogħla fl-istat fiss ta' distribuzzjoni (ara sezzjoni 4.2).
English: • convulsions (seizure)
Maltese: • reazzjonijiet allerġiċi severi • konvulżjonijiet (aċċessjonijiet)
English: • temporary blindness
Maltese: • għama temporanju
English: Recurrent or refractory testicular cancer
Maltese: Kanċer testikulari rikorrenti jew refrattorju
English: • increased bilirubin
Maltese: • żieda fil-bilirubina
English: Frequency Adverse Reaction (MedDRA Terms)
Maltese: Sistema tal-Klassifika tal-Organi Frekwenza Reazzjoni avversa (Termini MedDRA) Infezzjonijiet u infestazzjonijiet mhux magħruf infezzjoni
English: The safety and effectiveness in paediatric patients has not been established.
Maltese: Is-sigurtà u l-effettività f'pazjenti pedjatriċi ma ġietx stabbilita.
English: Myelosuppression (see section 4.4) with fatal outcome has been reported following administration of etoposide.
Maltese: Tossiċità Ematoloġika Majelosoppressjoni (ara sezzjoni 4.4) b'riżultat fatali ġiet irrappurtata wara l-għoti ta' etoposide.
English: Care must be taken whenever handling cytostatic products.
Maltese: Għandha jkun hemm kawtela meta wieħed imiss ma' prodotti ċitostatiċi.
English: - If you have recently been given a live vaccine, including Yellow fever vaccine.
Maltese: - Jekk dan l-aħħar inti ngħatajt tilqima ħajja, li tinkludi tilqima kontra d-Deni isfar (Yellow fever).
English: Currently available data are described in section 5.2 but no recommendation on a posology can be made.
Maltese: Data disponibbli hija deskritta fis-sezzjoni 5.2 iżda ma tista' ssir l-ebda rakkomandazzjoni dwar pożoloġija.
English: In addition, O-demethylation of the dimethoxyphenol ring occurs through the CYP450 3A4 isoenzyme pathway to produce the corresponding catechol.
Maltese: Barra minn hekk, O-demethylation taċ-ċirku dimethoxyphenol isseħħ permezz tal-passaġġ tal-iżoenzima CYP450 3A4 biex jipproduċi l-catechol korrispondenti.
English: Breastfeeding
Maltese: tromboċitopenija
English: Each 50 mg capsule, soft contains:
Maltese: Kull kapsula ratba ta' 50 mg fiha:
English: Impaired renal function
Maltese: ISTRUZZJONIJIET DWAR LUŻU
English: UNIQUE IDENTIFIER - HUMAN READABLE DATA PC: {number}
Maltese: DATA TA' REVIŻJONI TAT-TEST
English: The nausea and vomiting can usually be controlled by antiemetic therapy.
Maltese: Id-dardir u r-rimettar normalment jistgħu jiġu kkontrollati permezz ta' terapija antiemetika.
English: Since etoposide and its metabolites are not dialyzable, it can be administered pre- and post-haemodialysis (see section 4.9).
Maltese: Billi etoposide u l metaboliti tiegħu mhumiex dijalizzabbli, din il-mediċina tista' tingħata qabel u wara l-emodijalisi (ara sezzjoni 4.9).
English: DATE OF REVISION OF THE TEXT <{MM/YYYY}> <{DD/MM/YYYY}> <{DD month YYYY}> [To be completed nationally]
Maltese: Data tal-aħħar tiġdid: {JJ xahar SSSS}>
English: VEPESID and associated names (see Annex I) 50 mg capsule, soft VEPESID and associated names (see Annex I) 100 mg capsule, soft
Maltese: VEPESID u ismijiet assoċjati (ara Anness I) kapsula ratba ta' 50 mg VEPESID u ismijiet assoċjati (ara Anness I) kapsula ratba ta' 100 mg
English: Cardiac disorders common arrythmia, myocardial infarction
Maltese: Disturbi fil-qalb komuni arritmija, infart mijokardjali
English: - if you have low levels of a protein called albumin in your blood.
Maltese: - jekk għandek livelli baxxi ta' proteina msejħa albumina fid-demm tiegħek.
English: Tumour lysis syndrome (sometimes fatal) has been reported following the use of etoposide in association with other chemotherapeutic drugs (see section 4.4).
Maltese: Sindrome tal-lisi tat-tumur (xi kultant fatali) ġie rrappurtat wara l-użu ta' etoposide flimkien ma' mediċini kimoterapewtiċi oħra (ara sezzjoni 4.4).
English: Although minor differences in pharmacokinetic parameters between genders have been observed, these are not considered clinically significant.
Maltese: Għalkemm ġew osservati differenzi minuri fil-parametri farmakokinetiċi bejn is-sessi, dawn mhumiex ikkunsidrati li huma klinikament sinifikanti.
English: • skin problems such as itching or rash Uncommon side effects (affecting between 1 in 100 and 1 in 1000 people)
Maltese: Effetti sekondarji mhux komuni (li jaffettwaw bejn 1 u 100 u 1 minn kull 1,000 persuna)
English: The predominant macromolecular effect of etoposide seems to be the rupture of the double strand by an interaction with DNA
Maltese: L-effett makromolekulari predominanti ta' etoposide jidher li huwa l-qtugħ tad-double strand permezz ta' interazzjoni mad-DNA-topoisomerase II jew permezz tal-formazzjoni tar-radikali ħielsa.
English: - if you are taking any drugs with a similar mechanism of action as VEPESID.
Maltese: - jekk qed tieħu kwalunkwe mediċini b'mekkaniżmu ta' azzjoni simili għal dak ta' VEPESID.
English: Co-administration of antiepileptic drugs and VEPESID and associated names can lead to decreased seizure control due to pharmacokinetic interactions between the drugs.
Maltese: L-għoti flimkien ta' mediċini antiepilettiċi u VEPESID u ismijiet assoċjati, jista' jwassal għal tnaqqis fil-kontroll ta' aċċessjonijiet minħabba interazzjonijiet farmakokinetiċi bejn il-mediċini.
English: VEPESID and associated names is indicated in combination with other approved chemotherapeutic agents for the treatment of relapsed or refractory non-Hodgkin's lymphoma in adults.
Maltese: VEPESID u ismijiet assoċjati huwa indikat flimkien ma' sustanzi kimoterapewtiċi oħra approvati għall-kura ta' limfoma ta' Hodgkin rikorrenti jew refrattorja fl-adulti.
English: nausea and vomiting common diarrhoea, mucositis (including stomatitis and esophagitis)
Maltese: Neoplażmi beninni, malinni u dawk mhux speċifikati (inklużi ċesti u polipi)
English: Doses subsequent to initial dose should be adjusted if neutrophil count less than 500 cells/mm occurs for more than 5 days or is associated with fever or infection, if platelet count less than 25,000 cells/mm occurs, if any grade 3 or 4 toxicity develops or if renal clearance is less than 50 ml/min.
Maltese: Id-dożi sussegwenti wara l-ewwel doża għandhom jiġu aġġustati jekk ikun hemm għadd ta' newtrofili ta' inqas minn 500 ċellula/mm3 għal aktar minn 5 ijiem, jew jekk dan ikun assoċjat ma' deni jew infezzjoni, jekk ikun hemm għadd ta' plejtlits ta' inqas minn 25,000 ċellula/mm3, jekk tiżviluppa kwalunkwe tossiċità ta' grad 3 jew 4, jew jekk it-tneħħija mill-kliewi tkun ta' inqas minn
English: Vascular disorders common hypertension not known haemorrhage
Maltese: Disturbi vaskulari komuni pressjoni għolja mhux magħruf emorraġija
English: • blood disorders (this is why you will be having blood tests between courses of treatment)
Maltese: • disturbi fid-demm (din hi r-raġuni għaliex se jsirulek testijiet tad-demm bejn ilkorsijiet tal-kura)
English: An inverse relationship between plasma albumin levels and etoposide renal clearance is found in children.
Maltese: Hemm relazzjoni inversa bejn il-livelli tal-albumina fil-plażma u t-tneħħija ta' etoposide mill-kliewi fit-tfal.
English: For oral use.
Maltese: Mhux applikabbli.
English: Anaphylactic reactions manifested by chills, fever, tachycardia, bronchospasm, dyspnoea, and hypotension which can be fatal can occur with the initial dose of etoposide.
Maltese: Reazzjonijiet anafilattiċi li jidhru bħala tertir, deni, takikardija, bronkospażmu, qtugħ ta' nifs, u pressjoni baxxa li jistgħu jkunu fatali, jistgħu jseħħu bid-doża inizjali ta' etoposide.
English: APPROPRIATE
Maltese: JIS
English: Effects of other drugs on the pharmacokinetics of etoposide
Maltese: [Biex timtela mill-pajjiż partikolari] GĦAMLA FARMAĊEWTIKA U KONTENUT
English: Unbound fraction of etoposide correlates significantly with bilirubin in cancer patients.
Maltese: Il-frazzjoni mhux marbuta ta' etoposide jikkorrela b'mod sinifikanti mal-bilirubina f'pazjenti bil-kanċer.
English: VEPESID and associated names is indicated for the treatment of platinum-resistant/refractory epithelial ovarian cancer in adults.
Maltese: VEPESID u ismijiet assoċjati huwa indikat għall-kura ta' kanċer tal-ovarji epiteljali reżistenti/refrattarju għall-platinum fl-adulti.
English: In animal studies etoposide was associated with dose-related embryotoxicity and teratogenicity.
Maltese: Fi studji fuq l-annimali, etoposide kien assoċjat ma' embrijotossiċità u teratoġeniċità relatati maddoża.
English: Glucuronide and/or sulfate conjugates of etoposide are also excreted in human urine.
Maltese: Glucuronide u/jew konjugati tas-sulfat ta' etoposide jiġu eliminati wkoll fl-awrina tal-bniedem.