FrancophonIA/ELRC3.0 huggingface dataset:
English: Viramune is also available as an oral suspension, tablets or as prolonged-release tablets with lower strength.
Croatian: Viramune je također dostupan u obliku oralne suspenzije, tableta ili tableta s produljenim oslobađanjem manjih jačina.
English: • are  8 years of age and weigh 43.8 kg or more or
Croatian: •  8 godina statosti i 43,8 kg il više ili
English: If patients present with a suspected nevirapine-associated rash, liver function tests should be performed.
Croatian: Ako se u bolesnika sumnja na osip povezan nevirapinom, moraju se učiniti testovi jetrene funkcije.
English: The predetermined primary efficacy comparison was between the Viramune twice daily and the efavirenz treatment groups.
Croatian: Predodređena primarna djelotvornost liječenih skupina bila je uspoređena između Viramunea dvaput dnevno i efavirenza.
English: EE AUC  0.80 (0.67 - 0.97) EE Cmin ND
Croatian: EE AUC  0,80 (0,67 - 0,97) EE Cmin NO
English: Lamivudine and Viramune can be coadministered without dose suggesting no induction effect of nevirapine on lamivudine clearance.
Croatian: Lamivudin i Viramune se mogu istodobno primjenjivati bez ukazuje na odsustvo indukcijskog učinka nevirapina na klirens lamivudina.
English: Your child's doctor will inform you of the correct dose for your child.
Croatian: Djetetov liječnik će Vas obavijesittiti o ispravnoj dozi za Vaše dijete.
English: Fatal cases of SJS, TEN and drug reaction with eosinophilia and systemic symptoms have been reported.
Croatian: Prijavljeni su smrtni ishodi slučajeva SJS-a, TEN-a i reakcije na lijek uz eozinofiliju i sistemske simptome.
English: If you are uncertain please be sure to ask your child's doctor or pharmacist.
Croatian: Ako niste sigurni, molimo, svakako pitajte djetetovog liječnika ili ljekarnika.
English: Compounds using this metabolic pathway may have decreased plasma concentrations when coadministered with nevirapine.
Croatian: Tvari koji koriste ovaj metabolički put mogu imati smanjene koncentracije u plazmi kada se primjenjuju istodobno s nevirapinom.
English: Nevirapinemust not be restarted following severe hepatic, skin or hypersensitivity reactions (see section 4.3).
Croatian: Primjena nevirapina ne smije se ponovo započeti nakon teških jetrenih i kožnih reakcija ili reakcija preosjetljivosti (vidjeti dio 4.3).
English: No significant effect on rifabutin and Viramune mean PK parameters is seen.
Croatian: Bez značajnog učinka na rifabutin i srednje vrijednosti PK parametara Viramunea.
English: Patients experiencing rash during the 14-day lead-in period of 200 mg/day (4 mg/kg/day or 150 mg/m2/day for paediatric patients) should not have their Viramune dose increased until the rash has resolved.
Croatian: Bolesnicima kod kojih se tijekom 14-dnevnog uvodnog razdoblja uz dozu od 200 mg/dan (4 mg/kg/dan ili 150 mg/m2/dan za pedijatrijsku skupinu) pojavi osip ne smiju povećavati dozu Viramunea dok se osip ne povuče.
English: Patients were enrolled with CD4 counts <250 cells/mm
Croatian: Bili su uključeni bolesnici s brojem CD4 <250 stanica/mm
English: There are no data on the interchangeability of 100 mg compared to 400 mg prolonged-release tablets and therefore, 100 mg prolonged-release tablets should not be taken by adults.
Croatian: Ne postoje podaci o međusobnoj zamjenjivosti 100 mg u usporedbi s 400 mg tableta s produljenim oslobađanjem, te se stoga 100 mg tablete s produljenim oslobađanjem ne smiju primjenjivati u odraslih.
English: Patients with hereditary fructose intolerance (HFI) should not take/be given this medicinal product.
Croatian: Bolesnici s nasljednim nepodnošenjem fruktoze ne bi smjeli uzimati/primati ovaj lijek.
English: Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment.
Croatian: Autoimuni poremećaji (kao što su Gravesova bolest i autoimuni hepatitis) također su prijavljeni u uvjetima imunološke reaktivacije; međutim, vrijeme do nastupa događaja varira te može proći više mjeseci od početka liječenja do njihove pojave.
English: Each tablet contains 318 mg of lactose (as monohydrate).
Croatian: Jedna tableta sadrži 318 mg laktoze (u obliku hidrata).
English: Nevirapine has been shown to be an inducer of hepatic cytochrome P450 metabolic enzymes.
Croatian: Pokazalo se da nevirapin inducira jetrene citokrom P450 metaboličke enzime.
English: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection (AIDS defining illness), signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Croatian: U nekih bolesnika s uznapredovalom HIV infekcijom (AIDS) i anamnezom oportunističkih infekcija (bolest koja se definira kao AIDS), ubrzo nakon početka liječenja lijekovima protiv HIV -a mogu se pojaviti znakovi i simptomi upale uzrokovani prethodnim infekcijama.
English: Depending on resistance testing results, an etravirine-containing regimen may be used subsequently.
Croatian: Ovisno o rezultatima testova rezistencije, u takvim se slučajevima liječenje može nastaviti kombinacijom koja sadrži etravirin.
English: Nevirapine: Zidovudine had no effect on its pharmacokinetics.
Croatian: Nevirapin: zidovudin nije imao učinke na farmakokinetiku nevirapina.
English: The analysis of these samples of patients receiving Viramune immediate-release twice daily or Viramune prolonged-release once daily in combination with tenofovir and emtricitabine showed that isolates from 50 patients contained resistance mutations expected with a nevirapine-based regimen.
Croatian: Analiza ovih uzoraka bolesnika na Viramuneu s trenutnim oslobađanjem dvaput dnevno ili Viramuneu s produljenim oslobađanjem jednom dnevno u kombinaciji s tenofovirom i emtricitabinom pokazala je da izolati od 50 bolesnika sadrže mutacije rezistencije koje se očekuju uz liječenje bazirano na nevirapinu.
English: Viramune contains lactose and sodium
Croatian: Viramune sadrži laktozu i natrij
English: Therefore coadministration would likely result in altered plasma levels of cobicistat and Viramune.
Croatian: Stoga bi istodobna primjena vjerojatno rezultirala promijenjenim vrijednostima kobicistata i Viramunea u plazmi.
English: The 14-day”lead-in” period has been shown to lower the risk of skin rash.
Croatian: Pokazalo se da 14-dnevno „uvodno” razdoblje smanjuje rizik od osipa na koži.
English: Very common rash (12.5 %)
Croatian: Često osip (5,7%)
English: Viramune is also available as an oral suspension.
Croatian: Viramune je također dostupan u obliku oralne suspenzije.
English: Rare (may affect up to 1 in 1000 people): - sudden and intense inflammation of the liver (fulminant hepatitis) - drug reaction with systemic symptoms (drug reaction with eosinophilia and systemic symptoms)
Croatian: Rijetko (može se javiti u do 1 na 1000 osoba): - iznenadna i intenzivna upala jetre (fulminantni hepatitis) - reakcija na lijek sa sistemskim simptomima (reakcija na lijek uz eozinofiliju i sistemskim simptomima)
English: These events are commonly associated with other antiretroviral agents and may be expected to occur when Viramune is used in combination with other agents; however, it is unlikely that these events are due to treatment with Viramune.
Croatian: Ovi slučajevi često se vežu za druge antiretrovirusne lijekove te se njihova pojava može očekivati kada se Viramune primjenjuje u kombinaciji s drugim lijekovima; međutim, ne čini se da su ovakvi slučajevi uzrokovani liječenjem Viramuneom.
English: Tell your doctor if you experience any of the following clinical symptoms of liver damage: - loss of appetite - feeling sick (nausea) - vomiting - yellow skin (jaundice) - abdominal pain
Croatian: Obavijestite liječnika ako dobijete neki od sljedećih kliničkih simptoma oštećenja jetre: - gubitak apetita - mučnina - povraćanje - žuta koža (žutica) - bol u trbuhu
English: Clinical studies with prolonged-release tablets
Croatian: Klinička ispitivanja tableta s produljenim oslobađanjem
English: If you are uncertain please be sure to ask your child's doctor.
Croatian: Ako niste sigurni, molimo, upitajte djetetovog liječnika.
English: NET AUC  0.81 (0.70 - 0.93) NET Cmin ND
Croatian: NET AUC  0,81 (0,70 - 0,93) NET Cmin NO
English: Cases of hepatitis (severe and life-threatening hepatotoxicity, including fatal fulminant hepatitis) have been reported in patients treated with nevirapine.
Croatian: Prijavljeni su i slučajevi hepatitisa (teška i po život opasna hepatotoksičnost, uključujući fulminantni hepatitis sa smrtnim ishodom) u bolesnika liječenih nevirapinom.
English: Physicians and patients should be vigilant for prodromal signs or findings of hepatitis, such as anorexia, nausea, jaundice, bilirubinuria, acholic stools, hepatomegaly or liver tenderness.
Croatian: Liječnici i bolesnici moraju pažljivo pratiti pojavu prodromalnih znakova ili nalaza hepatitisa, kao što su anoreksija, mučnina, žutica, bilirubinurija, aholična stolica, hepatomegalija ili osjetljivost jetre.
English: INFORMATION IN BRAILLE Viramune 50 mg/5 ml
Croatian: 16. PODACI NA BRAILLEOVOM PISMU Viramune 50 mg/5 ml
English: INFORMATION IN BRAILLE Viramune 200 mg
Croatian: 16. PODACI NA BRAILLEOVOM PISMU Viramune 200 mg
English: The most frequently reported adverse reactions related to Viramune therapy, across all clinical studies, were rash, allergic reactions, hepatitis, abnormal liver function tests, nausea, vomiting, diarrhoea, abdominal pain, fatigue, fever, headache and myalgia.
Croatian: Najčešće prijavljene nuspojave povezane s terapijom Viramuneom u svim kliničkim studijama bile su osip, alergijske reakcije, hepatitis, abnormalni nalazi testova jetrene funkcije, mučnina, povraćanje, proljev, bol u abdomenu, umor, vrućica, glavobolja i mijalgija.
English: The effects of gender on the pharmacokinetics of Viramune prolonged-release have been investigated in study 1100.1486.
Croatian: Učinci spola na farmakokinetiku Viramunea s produljenim oslobađanjem ispitivani su u ispitivanju 1100.1486.
English: The first 18 weeks of treatment is a critical period which requires close monitoring (see section 4.4).
Croatian: Prvih 18 tjedana liječenja je kritično razdoblje koje zahtijeva pomno praćenje (vidjeti dio 4.4).
English: The side effects described below have been experienced by patients given Viramune prolonged-release tablets once daily in the maintenance phase:
Croatian: Nuspojave opisane u nastavku su imali bolesnici kojima su davane Viramune tablete s produljenim oslobađanjem jednom dnevno u fazi održavanja:
English: ANTIBIOTICS Clarithromycin 500 mg BID
Croatian: ANTIBIOTICI Klaritromicin 500 mg 2x/dan
English: Each tablet contains 200 mg nevirapine.
Croatian: Svaka tableta sadrži 200 mg nevirapina.
English: At 12 months, the Kaplan-Meier estimates of the likelihood of reaching the endpoint were 10 % in the Viramune group, 6 % in the efavirenz group, and 13 percent in the abacavir group (P=0.10 according to an intention-to-treat analysis).
Croatian: Vjerojatnost postizanja primarnog ishoda nakon 12 mjeseci liječenja, procjena po Kaplan-Meieru, bila je 10% za Viramune, 6% za efavirenz i 13% za abakavir (p=0,10 prema ITT analizi).
English: Viramune prolonged-release n=508*
Croatian: Viramune s produljenim oslobađanjem n=508*
English: Saquinavir/ritonavir The limited data available with saquinavir soft gel capsule boosted with ritonavir do not suggest any clinically relevant interaction between saquinavir boosted with ritonavir and nevirapine
Croatian: Ograničeni podaci dostupni za meke želatinaste kapsule sakvinavira pojačane ritonavirom ne ukazuju na klinički značajnu interakciju između sakvinavira pojačanog ritonavirom i nevirapinom
English: Weight Range (kg) for patients < 8 yrs of age
Croatian: Raspon težine (kg) za bolesnike < 8 godina
English: The double non-nucleoside study 2 NN was a randomised, open-label, multicentre prospective study comparing the NNRTIs nevirapine, efavirenz and both medicinal products given together.
Croatian: 2 NN - studija dvostrukih nenukleozida) je randomizirana, otvorena, multicentrična, prospektivna studija u kojoj su uspoređena dva NNRTI-a - nevirapin i efavirenz - kao monoterapija u usporedbi s njihovom kombinacijom.
English: Methadone-maintained patients beginning Viramune therapy should be monitored for evidence of withdrawal and methadone dose should be adjusted accordingly.
Croatian: Bolesnici na metadonskoj terapiji održavanja, a koji započinju terapiju Viramuneom treba pratiti radi znakova apstinencije te sukladno tome prilagoditi dozu metadona.
English: Dosage:
Croatian: Doza:
English: Some risk factors for developing serious cutaneous reactions have been identified, they include failure to follow the initial dosing of 200 mg daily (4 mg/kg or 150 mg/m2 for paediatric patients) during the lead-in period and a long delay between the initial symptoms and medical consultation.
Croatian: Prepoznati su određeni faktori rizika za razvoj ozbiljnih kožnih reakcija; oni uključuju propuste provođenja početnog doziranja od 200 mg dnevno (4 mg/kg ili 150 mg/m za pedijatrijsku skupinu) tijekom uvodnog razdoblja te dugog odgađanja javljanja liječniku nakon pojave početnih simptoma.
English: A durable response to Viramune for at least three years was documented in this study, and equivalence within a 10 % range was demonstrated between Viramune 200 mg twice daily and efavirenz with respect to treatment failure.
Croatian: Ispitivanje je pokazalo dugotrajan odgovor na Viramune tijekom najmanje 3 godine, te je dokazana ekvivalencija, unutar granice 10% između Viramunea 200 mg dvaput dnevno i efavirenza u pogledu neuspjeha liječenja.
English: Nevirapine pharmacokinetics in HIV-1 infected adults does not appear to change with age (range 1868 years).
Croatian: Smatra se da farmakokinetika nevirapina u odraslih osoba s HIV-1 infekcijom ne ovisi o dobi ( raspon 18-68 godina).
English: Based on clinical study experience with Viramune immediate-release tablets and oral suspension of 361 paediatric patients the majority of which received combination treatment with ZDV or/and ddI, the most frequently reported adverse events related to nevirapine were similar to those observed in adults.
Croatian: Na temelju iskustva kliničkog ispitivanja s Viramune tabletama s trenutnim oslobađanjem i oralnom suspenzijom s 361 pedijatrijskim bolesnikom, od kojih je većina primala kombinirano liječenje sa zidovudinom i/ili didanozinom, najčešće prijavljene nuspojave povezane s nevirapinom bile su slične onima opaženih u odraslih osoba.
English: Viramune 200 mg tablets, following the dosing schedule described above, are suitable for larger children, particularly adolescents, below the age of 16 who weigh more than 50 kg or whose body surface area is above 1.25 m2 according to the Mosteller formula.
Croatian: Viramune 200 mg tablete, prema prethodno opisanom rasporedu doziranja, pogodne su za primjenu u veće djece, osobito adolescenata, mlađih od 16 godina s tjelesnom težinom većom od 50 kg ili čija je tjelesna površina veća od 1,25 m2 prema Mostellerovoj formuli.
English: After 14 days, the usual dose is one 400 mg prolonged-release tablet once a day.
Croatian: Nakon 14 dana uobičajena doza je jedna 400 mg tableta s produljenim oslobađanjem jednom na dan.
English: Viramune prolonged-release tablets are only to be used for children three years of age and above.
Croatian: Viramune tablete s produljenim oslobađanjem primjenjuju se isključivo kod djece u dobi tri godine i stariji.
English: When Viramune prolonged-release was dosed with a high fat meal, the nevirapine AUC0-24,ss and Cmin,ss were approximately 94 % and 98 %, respectively, of the AUC0-24,ss and Cmin,ss measured when patients were dosed with Viramune immediate-release tablets.
Croatian: Kada je Viramune s produljenim oslobađanjem doziran uz visokomasni obrok, nevirapinski AUC0-24,ss i Cmin,ss bili su oko 94 % odnosno 98 %, u odnosu na AUC0-24,ss i Cmin,ss mjerene kada su bolesnici primali Viramune tablete s trenutnim oslobađanjem.
English: Such reactions may appear in the form of anaphylaxis (a severe form of allergic reaction) with symptoms such as: - rash - swelling of the face - difficulty breathing (bronchial spasm) - anaphylactic shock
Croatian: Takve reakcije mogu se pojaviti u obliku anafilaksije (teški oblik alergijske reakcije) sa simptomima kao što su: - osip - oticanje lica - problemi pri disanju (bronhospazam) - anafilaktički šok
English: Plasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapine.
Croatian: Najniže koncentracije boceprevira u plazmi bile su smanjenje prilikom primjene s NNRTI-om sa sličnim metaboličkim putem kao nevirapin.
English: Viramune oral suspension should be used within 6 months after first opening of the bottle.
Croatian: Viramune oralna suspenzija se mora upotrijebiti unutar 6 mjeseci nakon prvog otvaranja boce.
English: This is partly linked to restored health and life style, and in the case of blood lipids sometimes to the HIV medicines themselves.
Croatian: U liječenju HIV infekcije može doći do povećanja tjelesne težine i povišenja razine lipida i glukoze u krvi, što je djelomično povezano s obnovljenim zdravstvenim stanjem i stilom života, a u slučaju lipida u krvi ponekad sa samim lijekovima za HIV.
English: As Viramune must always be taken together with other HIV antiretroviral medicines, you should follow the instructions for your other medicines carefully.
Croatian: S obzirom da se Viramune uvijek uzima zajedno s drugim HIV antiretrovirusnim lijekovima, potrebno je pažljivo slijediti upute za druge lijekove koje uzimate.
English: Viramune prolonged-release tablets contain lactose (milk sugar).
Croatian: Viramune tablete s produljenim oslobađanjem sadrže laktozu (mliječni šećer).
English: Nevirapine had a median EC50 value (50% inhibitory concentration) of 63 nM against a panel of group M HIV-1 isolates from clades A, B, C, D, F, G, and H, and circulating recombinant forms (CRF), CRF01_AE, CRF02_AG and CRF12_BF replicating in human embryonic kidney 293 cells.
Croatian: Nevirapin ima medijan EC50 vrijednosti (koncentracija koja postiže 50% inhibicije) od 63 nM protiv HIV-1 niza izolata skupine M podtipova A, B, C, D, F, G, i H te cirkulirajućih rekombinantnih oblika CRF01_AE, CRF02_AG i CRF12_BF koja se replicira u kulturi ljudskih embrionalnih bubrežnih stanica 293.
English: The prolonged-release tablets shall be taken with liquid, and should not be broken or chewed.
Croatian: Tablete s produljenim oslobađanjem trebaju se uzimati s tekućinom i ne smiju se drobiti ili žvakati.
English: Abnormal liver functioning has been reported with the use of Viramune.
Croatian: Abnormalna funkcija jetre prijavljena je uz primjenu Viramunea.
English: Immune Reactivation Syndrome: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.
Croatian: Sindrom imunološke reaktivacije: U bolesnika inficiranih HIV-om s teškom imunodeficijencijom u vrijeme započinjanja kombinirane antiretrovirusne terapije (CART) može se pojaviti upalna reakcija na asimptomatske ili rezidualne oportunističke patogene te izazvati ozbiljno kliničko stanje ili pogoršanje simptoma.
English: - The other ingredients are lactose (as monohydrate), hypromellose, iron oxide yellow and magnesium stearate.
Croatian: - Drugi sastojci su laktoza (u obliku hidrata), hipromeloza, žuti željezov oksid i magnezijev stearat.
English: The frequency of this is unknown (see section 4.4).
Croatian: Učestalost ove nuspojave nije poznata (vidjeti dio 4.4).
English: Patients who interrupt nevirapine dosing for more than 7 days should restart the recommended dosing regimen using the two week lead-in period of Viramune immediate-release.
Croatian: Bolesnici koji prekinu doziranje nevirapina na dulje od 7 dana moraju ponovno početi s preporučenim režimom doziranja uz dvotjedno uvodno razdoblje primjene Viramunea s trenutnim oslobađanjem.
English: If a hypersensitivity reaction occurs, characterised by rash with constitutional symptoms such as fever, arthralgia, myalgia and lymphadenopathy, plus visceral involvement, such as hepatitis, eosinophilia, granulocytopenia, and renal dysfunction, nevirapine must be permanently stopped and not be reintroduced (see section 4.3).
Croatian: Ako dođe do pojave reakcije preosjetljivosti, karakterizirane osipom s općim simptomima kao što su vrućica, artralgija, mijalgija i limfadenopatija, uz visceralne poremećaje, kao što su hepatitis, eozinofilija, granulocitopenija i disfunkcija bubrega, terapija nevirapinom mora se trajno obustaviti i ne smije se ponovo uvoditi (vidjeti dio 4.3).
English: Polysorbate 80
Croatian: polisorbat 80,
English: Viramune should be administered by physicians who are experienced in the treatment of HIV infection.
Croatian: Viramune moraju primjenjivati liječnici s iskustvom u liječenju HIV-infekcije.
English: 3 had a 12 fold higher risk of symptomatic hepatic adverse reactions compared to women with CD4 counts <250 cells/mm
Croatian: 3 imaju 12 puta viši rizik simptomatskih jetrenih nuspojava u usporedbi sa ženama s brojem CD4 <250 stanica/mm
English: If you ever observe any rash symptoms, inform your doctor immediately.
Croatian: Ako ikad opazite simptome bilo kakvog osipa, odmah obavijestite svog liječnika.
English: Severe and life-threatening hepatotoxicity, including fatal fulminant hepatitis, has occurred in patients treated with nevirapine.
Croatian: Teška i po život opasna hepatotoksičnost, uključujući fulminantni hepatitis sa smrtnim ishodom, dogodila se u bolesnika liječenih nevirapinom.
English: Emtricitabine is not an inhibitor of human CYP 450 enzymes.
Croatian: Emtricitabin nije inhibitor CYP 450 enzima u ljudi.
English: The observed geometric mean ratios of Viramune prolonged-release to Viramune immediate-release were ~90 % for Cmin,ss and AUCss with 90% confidence intervals within 80 %-125 %; the ratio for Cmax,ss was lower and consistent with a once-daily prolonged-release dosage form.
Croatian: Opaženi omjeri geometrijske srednje vrijednosti Viramunea s produljenim oslobađanjem i Viramunea s trenutnim oslobađanjem bili su ~90 % za Cmin,ss i AUCss s intervalom pouzdanosti 90 % unutar 80 %-125 %; omjer za Cmax,ss bio je niži i odgovarao je jednokratnom dnevnom obliku doziranja s produljenim oslobađanjem.
English: These have included cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity reactions characterised by rash, constitutional findings and visceral involvement.
Croatian: One uključuju slučajeve StevensJohnsonovog sindroma, toksične epidermalne nekrolize i reakcije preosjetljivosti karakterizirane osipom, općim simptomima i visceralnim poremećajima.
English: Studies in treatment-experienced patients
Croatian: Studije o liječenju bolesnika koji su prethodno bili liječeni
English: Boehringer Ingelheim Ellas A.E. 5th km Paiania-Markopoulo 194 00 Koropi
Croatian: 5th km Paiania-Markopoulo 194 00 Koropi
English: If you are receiving post-menopausal hormone therapy, ask your doctor for advice before taking this medicine.
Croatian: Ako primate hormonsku terapiju u post menoapuzi, obratite se svom liječniku za savjet prije nego uzmete ovaj lijek.
English: Nevirapine: Co-administration of ritonavir does not lead to any clinically relevant change in nevirapine plasma levels.
Croatian: Nevirapin: Istodobne primjena ritonavira ne vodi do klinički značajne promjene u razinama nevirapina u plazmi.
English: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Croatian: Bolesnici s rijetkim nasljednim poremećajem nepodnošenja fruktoze, malapsorpcijom glukoze i galaktoze ili insuficijencijom sukrazaizomaltaza ne bi smjeli uzimati ovaj lijek.