FrancophonIA/ELRC3.0 huggingface dataset:
English: EU/1/06/340/003 5 single-dose containers EU/1/06/340/004 30 single-dose containers EU/1/06/340/005 90 single-dose containers
Slovenian: EU/1/06/340/003 5 enoodmernih vsebnikov EU/1/06/340/004 30 enoodmernih vsebnikov EU/1/06/340/005 90 enoodmernih vsebnikov
English: Studies in rodents produced species-specific abortion at systemic exposure levels 33- to 97-times that achieved in humans after ocular administration.
Slovenian: Pri študijah na glodavcih so zabeležili za vrsto specifične abortuse pri sistemski izpostavljenosti, ki je bila 33- do 97-krat večja od vrednosti, uporabljenih med zdravljenjem pri človeku.
English: Whilst keeping the eye closed, press your finger against the corner of the closed eye (the site where the eye meets the nose) and hold for 2 minutes.
Slovenian: Ko imate oko zaprto, s prstom pritisnite na notranji očesni kotiček (na mestu, kjer se oko dotika nosu) in držite 2 minuti.
English: The prostamide receptor, however, has not yet been structurally identified.
Slovenian: Struktura prostamidnega receptorja še ni bila raziskana.
English: No functional or microscopic changes related to the periocular effects have been observed, and the mechanism of action for the periocular changes is unknown.
Slovenian: Funkcionalnih ali mikroskopskih sprememb, povezanih s periokularnim učinkom, ni bilo opaziti.
English: This risk may increase with elderly age, and the psychiatric medical history appears to be a risk factor rather than confounding for development of hallucinations following timolol containing eye drops administration
Slovenian: To tveganje se lahko s starostjo poveča, psihiatrična zdravstvena anamneza pa je prej dejavnik tveganja kot pa moteči dejavnik za razvoj halucinacij po uporabi kapljic za oči s timololom.
English: After ocular administration, the systemic exposure of bimatoprost is very low with no accumulation over time.
Slovenian: Pri lokalni uporabi na očesu je sistemska absorpcija bimatoprosta zelo nizka in brez dolgotrajnega kopičenja.
English: Contact lenses must be removed prior to application, with at least a 15-minute wait before reinsertion.
Slovenian: Pred uporabo zdravila je treba odstraniti kontaktne leče in počakati najmanj 15 minut pred ponovno namestitvijo.
English: 2017;26(9):e214-e216, four strong cases of hallucinations with ophthalmic timolol (single-substance) were reported, all in elderly patients with coexisting CNS pathology.
Slovenian: 2017; 26(9): e214-e216 so poročali o štirih primerih halucinacij pri jemanju oftalmološkega zdravila s timololom (ena učinkovina), in sicer pri starejših bolnikih s sočasno boleznijo osrednjega živčevja.
English: The mechanism of action by which bimatoprost reduces intraocular pressure in man is by increasing aqueous humour outflow through the trabecular meshwork and enhancing uveoscleral outflow.
Slovenian: Mehanizem delovanja, pri katerem bimatoprost zmanjšuje povišan očesni tlak pri človeku, je povečano iztekanje prekatne vodice skozi trabekularno omrežje in povečanje uveoskleralnega iztekanja.
English: Part of the dose is absorbed systemically where it is extensively metabolised in the liver.
Slovenian: Del odmerka se absorbira sistemsko in se večinoma presnovi v jetrih.
English: In studies of bimatoprost 0.3 mg/ml in patients with glaucoma or ocular hypertension, it has been shown that more frequent exposure of the eye to more than 1 dose of bimatoprost daily may decrease the IOP-lowering effect.
Slovenian: V študijah, pri katerih so sodelovali bolniki z glavkomom ali okularno hipertenzijo, ki so jemali bimatoprost 0,3 mg/l, so poročali, da lahko pogostejša izpostavljenost več kot 1 odmerku bimatoprosta na dan zmanjša učinek zniževanja znotrajočesnega tlaka.
English: It is acknowledged that in more than half of cases timolol eye drops were the only suspect drug, although additional risk factors such as elderly age, underlying disease or concomitant drugs may have contributed.
Slovenian: V več kot polovici primerov so kapljice za oči s timololom edino zdravilo, za katerega se sumi, da je povzročilo domnevne neželene učinke, čeprav so lahko k temu prispevali dodatni dejavniki tveganja, kot so starost, osnovna bolezen ali sočasno jemanje drugih zdravil.
English: Contact with soft contact lenses must be avoided.
Slovenian: Preprečite stik z mehkimi kontaktnimi lečami.
English: You must not use the bottle if the tamper-proof seal on the bottle neck is broken before you first use it.
Slovenian: Plastenke ne smete uporabiti, če je pečat zaščitne zaporke na vratu plastenke pred prvo uporabo poškodovan.
English: Overt cardiac failure, cardiogenic shock.
Slovenian: Odkrito srčno popuščanje, kardiogeni šok.
English: Bimatoprost is moderately distributed into body tissues and the systemic volume of distribution in humans at steady-state was 0.67 1/kg.
Slovenian: Bimatoprost se zmerno porazdeli v telesnih tkivih; sistemski volumen porazdelitve v stanju dinamičnega ravnovesja pri človeku je bil 0,67 l/kg.
English: In two 12-month studies where systemic absorption was measured, no accumulation was observed with either of the individual components.
Slovenian: V dveh 12-mesečnih študijah, pri katerih so merili sistemsko absorpcijo, niso opazili kopičenja nobene od posameznih sestavin.
English: • Red scaly patches on skin; skin rash
Slovenian: • rdeče luske na koži, kožni izpuščaj,
English: It is known that ophthalmic beta-blockers (like e.g. timolol) in some cases can cause systemic side effects.
Slovenian: Znano je, da lahko očesni zaviralci receptorjev beta (kot je npr. timolol) v nekaterih primerih povzročijo sistemske stranske učinke.
English: Once opened, solutions may become contaminated, which can cause eye infections.
Slovenian: Po odprtju plastenke lahko pride do onesnaženja raztopine, kar lahko povzroči okužbo očesa.
English: Gently pull down the lower eyelid until there is a small pocket.
Slovenian: Nežno povlecite spodnjo veko navzdol, da nastane žepek.
English: Do not use the drops while your contact lenses are in your eyes.
Slovenian: Ne uporabljajte kapljic za oko, dokler imate vstavljene kontaktne leče.
English: No specific interaction studies have been performed with the bimatoprost / timolol fixed combination.
Slovenian: Študij medsebojnega delovanja za fiksno kombinacijo bimatoprosta/timolola niso izvedli.
English: Animal studies with timolol have shown reproductive toxicity at doses significantly higher than would be used in clinical practice (see section 5.3).
Slovenian: Študije na živalih so pokazale reproduktivno toksičnost pri odmerkih, bistveno višjih od tistih, kot bi jih uporabili v klinični praksi (glejte poglavje 5.3).
English: Timolol is not extensively bound to plasma.
Slovenian: Timolol se ne veže v veliki meri na plazemske proteine.
English: • Low blood pressure, high blood pressure, swelling or coldness of your hands, feet and extremities, caused by constriction of your blood vessels
Slovenian: • nizek krvni tlak, visok krvni tlak, otekle ali hladne dlani, stopala in okončine, ki so posledica zožitev krvnih žil,
English: Very rare Not known
Slovenian: Zelo redki Neznana pogostnost
English: After 12 months treatment with bimatoprost eye drops alone, the incidence was 1.5% and did not increase following 3 years treatment.
Slovenian: Po 12 mesecih zdravljenja s kapljicami za oko, ki so vsebovale samo bimatoprost, je bila incidenca 1,5 % in se v naslednjih 3 letih zdravljenja ni povečala.
English: However, consideration should be given to the likelihood of compliance when considering either morning or evening dosing (see section 5.1).
Slovenian: Vendar je pri izbiri jutranjega ali večernega odmerjanja treba upoštevati tudi, kaj bolniku bolj ustreza (glejte poglavje 5.1).
English: In all four cases, positive de-challenge and re-challenge were reported.
Slovenian: V vseh štirih primerih so poročali o izzvenitvi neželenega učinka po prenehanju zdravljenja (positive de-challenge)
English: The colour of your iris may also go darker over time.
Slovenian: Sčasoma vam lahko potemni tudi iris (šarenica).
English: The chance of having side effects after using eye drops is lower than when medicines are for example, taken by mouth or injected.
Slovenian: Pojav neželenih učinkov ob uporabi kapljic za oko je manjši kot npr. pri peroralem zaužitju ali injiciranju zdravila.
English: If you forget to use GANFORT, use a single drop as soon as you remember, and then go back to your regular routine.
Slovenian: Če ste pozabili uporabiti zdravilo GANFORT, si vkapajte eno kapljico takoj, ko se spomnite, in nadaljujte kot ponavadi.
English: GANFORT single-dose achieved noninferior IOP-lowering efficacy to GANFORT (multi-dose formulation): the upper limit of the 95% CI of the between-treatment difference was within the pre-defined 1.5 mm Hg margin at each timepoint evaluated (hours 0, 2, and 8) at week 12 (for the primary analysis), and also at weeks 2 and 6, for mean worse eye IOP change from baseline (worse eye IOP refers to the eye with the higher mean diurnal IOP at baseline).
Slovenian: GANFORT je bila enako učinkovita pri znižanju znotrajočesnega tlaka (IOT) kot večodmerna oblika zdravila GANFORT: zgornja meja 95 % CI razlike med zdravljenjem je bila znotraj predhodno določene meje 1,5 mm Hg pri vsaki ocenjeni časovni točki (0, 2 in 8 ur) v 12. tednu (za primarno analizo) ter tudi v 2. in 6. tednu, kar velja za oko, v katerem je bil povprečni IOT slabši od osnovne vrednosti (IOT v slabšem očesu se nanaša na oko z višjim povprečnim diurnalnim IOT pri osnovni vrednosti).
English: This ADR is most likely linked to the active substance bimatoprost, and not the preservative.
Slovenian: Ta neželeni učinek je najverjetneje povezan z učinkovino bimatoprost in ne s konzervansom.
English: • Cough, worsening of asthma, worsening of the lung disease called chronic obstructive pulmonary disease (COPD)
Slovenian: • kašelj, poslabšanje astme, poslabšanje pljučne bolezni, imenovane kronična obstruktivna pljučna bolezen (KOPB),
English: Tell your doctor if you are using or intend to use medicines to lower blood pressure, heart medicine, medicines to treat diabetes, quinidine (used to treat heart conditions and some types of malaria) or medicines to treat depression known as fluoxetine and paroxetine.
Slovenian: Obvestite zdravnika, če uporabljate ali nameravate uporabljati zdravila za zniževanje krvnega tlaka, zdravila proti srčnim boleznim, zdravila za zdravljenje sladkorne bolezni, kinidin (za zdravljenje bolezni srca in nekaterih vrst malarije) ali zdravila za zdravljenje depresije, kot sta fluoksetin in paroksetin.
English: The precise mechanism of action is not clearly established, but inhibition of the increased cyclic AMP synthesis caused by endogenous beta-adrenergic stimulation is probable.
Slovenian: Natančen mehanizem delovanja še ni pojasnjen, verjetno gre za zaviranje povišane sinteze cikličnega AMP kot posledica endogene stimulacije adrenergičnih receptorjev beta.
English: • Depression; memory loss; hallucination
Slovenian: • depresija, izguba spomina, halucinacije
English: To help you remember, write down the date that you opened it in the space on the carton.
Slovenian: Da bi si to lažje zapomnili, si datum odprtja plastenke zapišite v prostor na ovojnini.
English: GANFORT has negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo GANFORT ima zanemarljiv vpliv na sposobnost vožnje in upravljanje strojev.
English: It should be administered at the same time each day.
Slovenian: Zdravilo je treba uporabljati vsak dan ob istem času.
English: Systemic absorption of the individual components was minimal and not affected by co-administration in a single formulation.
Slovenian: Sistemska absorpcija posameznih sestavin je bila minimalna, sočasno dajanje kombiniranega zdravila pa nanjo ni vplivalo.
English: Summary of the safety profile
Slovenian: GANFORT Povzetek varnostnega profila
English: Like other medicines applied into eyes, timolol is absorbed into the blood.
Slovenian: Kot pri drugih zdravilih za oko, se timolol absorbira v krvni obtok.
English: The preservative in GANFORT, benzalkonium chloride, may cause eye irritation.
Slovenian: Konzervans v zdravilu GANFORT, benzalkonijev klorid, lahko povzroči draženje oči.
English: Not known bronchospasm (predominantly in patients with pre-existing bronchospastic disease) 2, asthma
Slovenian: občasni dispneja neznana pogostnost bronhospazem (zlasti pri bolnikih z obstoječo boleznijo, ki vključuje bronhospazem)2,
English: However, at therapeutic doses of timolol in eye drops it is not likely that sufficient amounts would be present in breast milk to produce clinical symptoms of beta-blockade in the infant.
Slovenian: Kljub temu pri terapevtskih odmerkih v kapljicah za oči ni pričakovati, da bi bile v materinem mleku prisotne zadostne količine, ki bi vodile do kliničnih simptomov antagonistov adrenergičnih receptorjev beta pri dojenčku.
English: Bimatoprost is eliminated primarily by renal excretion, up to 67% of an intravenous dose administered to healthy volunteers was excreted in the urine, 25% of the dose was excreted via the faeces.
Slovenian: Do 67 % intravenskega odmerka, danega zdravim preiskovancem, je bilo izločeno z urinom, 25 % odmerka pa je bilo izločeno z blatom.
English: If GANFORT is accidentally ingested, the following information may be useful: in two-week oral rat and mouse studies, doses of bimatoprost up to 100 mg/kg/day did not produce any toxicity.
Slovenian: Če zdravilo GANFORT pomotoma zaužijete, je lahko koristna naslednja informacija: v dvotedenskih študijah pri peroralnem zaužitju pri podganah in miših odmerki v koncentraciji do 100 mg/kg/dan niso bili toksični.
English: 10 single-dose containers.
Slovenian: 10 enoodmernih vsebnikov.
English: If GANFORT single-dose is accidentally ingested, the following information may be useful: in 2-week oral mice and rats studies, doses of bimatoprost up to 100 mg/kg/day did not produce any toxicity; this corresponds to a human equivalent dose of 8.1 and 16.2 mg/kg, respectively.
Slovenian: Če zdravilo GANFORT (enoodmerna oblika) pomotoma zaužijete, so lahko koristne naslednje informacije: 2-tedenske študije na miših in podganah so pokazale, da pri peroralnih odmerkih bimatoprosta do 100 mg/kg/dan ni prišlo do toksičnosti; to ustreza odmerku 8,1 oziroma 16,2 mg/kg pri človeku.
English: In conclusion, there is evidence to suggest that ophthalmic timolol can be associated with hallucinations, either through systemic effects or through CNS penetration of timolol.
Slovenian: Če povzamemo, obstajajo dokazi, ki nakazujejo na morebitno vzročno povezanost med uporabo oftalmotoloških zdravil s timololom in halucinacijami, bodisi s sistemskimi učinki ali pa s prehodom timolola v osrednje živčevje.
English: After 12 months treatment with GANFORT, the incidence of iris pigmentation was 0.2%.
Slovenian: Po 12 mesecih zdravljenja z zdravilom GANFORT je bila incidenca pigmentacije šarenice 0,2 %.
English: However, this finding is not clinically relevant as systemic exposure for both elderly and young subjects remained very low from ocular dosing.
Slovenian: Rezultati pa niso klinično pomembni, ker je sistemska izpostavljenost pri očesni uporabi za obe starostni skupini bolnikov zelo nizka.
English: Therefore in view of the data presented in the reviewed PSUR, the PRAC considers that changes to the product information of medical products containing timolol were warranted.
Slovenian: Glede na podatke, predstavljene v pregledanem redno posodobljenem poročilu o varnosti zdravila (PSUR), je Odbor za oceno tveganja na področju farmakovigilance (PRAC) presodil, da so spremembe v informacijah o zdravilu za zdravila, ki vsebujejo timolol, upravičene.
English: A total of 56 cases have been derived from EudraVigilance for ophthalmic timolol products including 5 for the bimatoprost/timolol combination product which have given rise to various “Perception disturbances” like: Hallucination; Derealisation; Hallucination, auditory; Hallucination, visual.
Slovenian: vključno s 5 primeri za kombinacijo bimatoprosta/timolola, pri katerih so se pojavile različne »motnje zaznavanja«, kot so: halucinacije; derealizacija; halucinacije - slušne, halucinacije - vidne.
English: Patients with severe peripheral circulatory disturbance/disorders (i.e. severe forms of Raynaud's disease or Raynaud's syndrome) should be treated with caution.
Slovenian: Pri zdravljenju bolnikov s hudimi motnjami/boleznimi perifernega krvnega obtoka (npr. hudimi oblikami Raynaudove bolezni ali Raynaudovega sindroma) je potrebna previdnost.
English: The following pack sizes are available: cartons containing 1 or 3 bottles of 3 ml.
Slovenian: Na voljo so naslednja pakiranja: pakiranje z 1 ali 3 plastenkami s 3 ml raztopine.
English: No enhancement of the systemic absorption of the individual active substances has been observed.
Slovenian: Povečane sistemske absorpcije posameznih zdravilnih učinkovin niso opazili.
English: All containers should be kept in the pouch and carton to protect from light and moisture and discarded 10 days after first opening the pouch.
Slovenian: Vse vsebnike shranjujte v vrečici in škatli, za zagotovitev zaščite pred svetlobo in vlago in jih zavrzite v 10 dneh po prvem odprtju vrečice.
English: A 12-week (double-masked, randomized, parallel group) clinical study compared the efficacy and safety of GANFORT single-dose with GANFORT (multi-dose formulation) in patients with glaucoma or ocular hypertension.
Slovenian: V 12-tedenski (dvojno maskirani, randomizirani) klinični študiji (z vzporednima skupinama) so primerjali učinkovitost in varnost enoodmerne oblike zdravila GANFORT z večodmerno obliko zdravila GANFORT pri bolnikih z glavkomom ali okularno hipertenzijo.
English: Additional side effects have been seen in patients using eye drops containing timolol or bimatoprost and so may possibly be seen with GANFORT.
Slovenian: Dodatne neželene učinke so opazili pri bolnikih, ki so uporabljali kapljice za oko, ki so vsebovale timolol ali bimatoprost, in se lahko pojavijo tudi pri zdravilu GANFORT.
English: Mydriasis resulting from concomitant use of ophthalmic beta-blockers and adrenaline (epinephrine) has been reported occasionally.
Slovenian: O midriazi, ki je nastala kot posledica sočasne uporabe očesnih antagonistov adrenergičnih receptorjev beta in adrenalina (epinefrina), so poročali občasno.
English: Anaphylactic reactions
Slovenian: Anafilaktična reakcija
English: GANFORT single-dose has negligible influence on the ability to drive and use machines.
Slovenian: Zdravilo GANFORT (enoodmerna oblika) ima zanemarljiv vpliv na sposobnost vožnje in upravljanje strojev.
English: Symptoms of systemic timolol overdose include: bradycardia, hypotension, bronchospasm, headache, dizziness, shortness of breath, and cardiac arrest.
Slovenian: Simptomi sistemskega prevelikega odmerjanja timolola so naslednji: bradikardija, hipotenzija, bronhospazem, glavobol, omotica, oteženo dihanje in zastoj srca.
English: GANFORT should not be used in children and teenagers under 18.
Slovenian: Zdravilo GANFORT se ne sme uporabljati pri otrocih in najstnikih, mlajših od 18 let.
English: Recommended dosage in adults (including older people) The recommended dose is one drop of GANFORT in the affected eye(s) once daily, administered either in the morning or in the evening.
Slovenian: Priporočeno odmerjanje pri odraslih (vključno s starejšimi ljudmi) Priporočeni odmerek je ena kapljica v prizadeto oko (oči) enkrat dnevno, zjutraj ali zvečer.
English: GANFORT eye drops are used to treat high pressure in the eye in adults, including the elderly.
Slovenian: Kapljice za oko GANFORT se uporabljajo za zdravljenje visokega očesnega tlaka pri odraslih, vključno s starostniki.
English: Each ml of solution contains 0.05 mg of benzalkonium chloride.
Slovenian: En ml raztopine vsebuje 0,05 mg benzalkonijevega klorida.
English: Reactive airway disease including bronchial asthma or a history of bronchial asthma, severe chronic obstructive pulmonary disease.
Slovenian: Reaktivna bolezen dihal, vključno z bronhialno astmo ali bronhialno astmo v anamnezi, huda kronična obstruktivna pljučna bolezen.
English: Sinus bradycardia, sick sinus syndrome, sino-atrial block, second or third degree atrioventricular block, not controlled with pace-maker.
Slovenian: Sinusna bradikardija, sindrom bolnega sinusnega vozla, sinuatrilani blok, atrioventrikularni (AV) blok druge in tretje stopnje, ki ni nadzorovan s srčnim spodbujevalnikom.
English: In two 12-month studies of GANFORT (multi-dose formulation) in which systemic absorption was measured, no accumulation was observed of either of the individual components.
Slovenian: V dveh 12-mesečnih študijah zdravila GANFORT (večodmerna oblika), pri katerih so merili sistemsko absorpcijo, niso opazili kopičenja nobene od posameznih sestavin.
English: GANFORT should be used with caution in patients with active intraocular inflammation (e.g. uveitis) because the inflammation may be exacerbated.
Slovenian: Zdravilo GANFORT je treba uporabljati previdno pri bolnikih z akutnim intraokularnim vnetjem (npr. uveitis), ker se lahko vnetje poslabša.
English: This may cause similar side effects as seen with ”intravenous” and /or “oral” beta-blocking agents.
Slovenian: To lahko povzroči podobne neželene učinke, kot jih opazimo pri »intravenski« in/ali »peroralni« uporabi antagonistov adrenergičnih receptorjev beta.
English: Affecting other parts of the body difficulty breathing / wheezing, symptoms of allergic reaction (swelling, redness of the eye and rash of the skin), changes in your taste sensation, slowing of heart rate, difficulty sleeping, nightmare, asthma, hair loss, tiredness.
Slovenian: Učinki na druge dele telesa težave pri dihanju/sopihanje, simptomi alergijske reakcije (otekanje, pordelost oči in izpuščaj na koži), spremembe v okušanju, upočasnitev srčnega utripa, težave s spanjem, nočne more, astma, izpadanje dlak, utrujenost.
English: Not known hypersensitivity reactions including signs or symptoms of allergic dermatitis, angioedema, eye allergy
Slovenian: Bolezni imunskega sistema neznana pogostnost preobčutljivostne reakcije, vključno z znaki ali simptomi alergijskega dermatitisa, angioedema, alergije oči
English: Nervous system disorders syncope1, cerebrovascular accident1, increase in signs and symptoms of myasthenia gravis1, paraesthesia1, cerebral ischaemia1
Slovenian: Bolezni živčevja sinkopa1, cerebrovaskularni dogodki1, povečanje znakov in simptomov miastenije gravis1, parestezija1, cerebralna ishemija1
English: Do not stop using Ganfort without speaking to your doctor.
Slovenian: Ne prenehajte uporabljati zdravila GANFORT brez posveta z zdravnikom.
English: Based on this outcome, removal of the note in the SmPC in section 4.8 linking the ADR ‘Superior sulcus deepening' to only products containing preservative is recommended.
Slovenian: Na podlagi tega izida priporočamo odstranitev opombe v Povzetku glavnih značilnosti zdravila v poglavju 4.8, ki povezuje neželeni učinek »poglobitev superiornega sulkusa« le z zdravili, ki vsebujejo konzervanse.
English: Bimatoprost penetrates the human cornea and sclera well in vitro.
Slovenian: Bimatoprost in vitro dobro prodira v človeško roženico in sklero.
English: The usual dose is one drop once a day, either in the morning or in the evening in each eye that needs treatment.
Slovenian: Običajni odmerek je ena kapljica zdravila GANFORT dnevno, zjutraj ali zvečer, v vsako zdravljeno oko.
English: A study of patients with renal failure showed that timolol did not dialyse readily.
Slovenian: Študija pri bolnikih z ledvično odpovedjo je pokazala, da se timolol težko odstranjuje z dializo.
English: The elimination half-life, determined after intravenous administration, was approximately 45 minutes; the total blood clearance was 1.5 1/hr/kg.
Slovenian: Po intravenskem dajanju je bila razpolovna doba izločanja približno 45 minut; popoln očistek krvi je bil
English: Turn the bottle upside down and squeeze it to release one drop into each eye that needs treatment.
Slovenian: Plastenko obrnite na glavo in jo stisnite, da vkapate eno kapljico zdravila v vsako zdravljeno oko.
English: Opened (1)
Slovenian: Odprto (1)
English: Vascular disorders hypotension1, hypertension2, Raynaud's phenomenon1, cold hands and feet1
Slovenian: Žilne bolezni hipotenzija1, hipertenzija2, Raynaudov fenomen1, mrzle dlani in stopala1