FrancophonIA/ELRC3.0 huggingface dataset:
English: Shake bottle for approximately 10 seconds before use.
Danish: Flasken omrystes i cirka 10 sek. før brug.
English: Oral Contraceptives [CYP3A4 substrate; CYP2C19 inhibitor]
Danish: Oral antikonception [CYP3A4-substrat; CYP2C19hæmmer]
English: Voriconazole may be coadministered with efavirenz if the voriconazole maintenance dose is increased to 400 mg BID and the efavirenz dose is decreased to 300 mg QD.
Danish: Voriconazol kan administreres sammen med efavirenz hvis voriconazol vedligeholdelsesdosis øges til 400 mg BID og efavirenz dosis reduceres til 300 mg QD.
English: Oral suspension Children aged 2 to less than 12 years and teenagers aged 12 to 14 years weighing less than 50 kg
Danish: Oral suspension Børn fra 2 år til under 12 år samt teenagere fra 12 til 14 år, der vejer mindre end 50 kg
English: Reconstituted VFEND concentrate needs to be further diluted with sodium chloride (0.9%) infusion solution within the infusion bag before it is infused.
Danish: Rekonstitueret VFEND koncentrat skal fortyndes yderligere med 9 mg/ml (0,9%) natriumchloridinfusionsvæske i infusionsposen før infusion.
English: Blister foil for 50 mg film-coated tablets (all blister packs)
Danish: Blisterfolie for 50 mg filmovertrukne tabletter (alle blisterpakninger)
English: This medicinal product is for single use only and any unused solution should be discarded.
Danish: Dette lægemiddel er udelukkende til éngangsbrug, og ubrugt opløsning skal kasseres.
English: Shake the closed bottle of constituted suspension for approximately 10 seconds before use.
Danish: Omryst den lukkede flaske med den færdigblandede suspension i ca. 10 sek. før brug.
English: Ritonavir Cmax and AUC ↔ Voriconazole Cmax  66% Voriconazole AUC  82%
Danish: Ritonavir Cmax og AUC ↔ Voriconazol Cmax  66% Voriconazol AUC  82%
English: Dosage adjustments in case of co-administration Rifabutin or phenytoin may be coadministered with voriconazole if the maintenance dose of voriconazole is increased to 5 mg/kg intravenously twice daily, see sections 4.4 and 4.5.
Danish: Dosisjusteringer i tilfælde af samtidig administration Rifabutin eller phenytoin kan administreres sammen med voriconazol, hvis vedligeholdelsesdosis af voriconazol øges til 5 mg/kg intravenøst to gange dagligt , se pkt.
English: Discard the VFEND vial if vacuum does not pull the diluent into the vial.
Danish: VFEND-hætteglasset kasseres, hvis vakuum ikke kan trække fortyndingsmidlet op i hætteglasset.
English: Dermatological reactions Dermatological reactions were very common in patients treated with voriconazole in clinical trials, but these patients had serious underlying diseases and were receiving multiple concomitant medicinal products.
Danish: Dermatologiske reaktioner Dermatologiske reaktioner var meget almindelige hos patienter behandlet med voriconazol i kliniske studier, men disse patienter havde alvorlige tilgrundliggende sygdomme, og fik samtidig behandling med anden medicin.
English: Monitoring for voriconazoleassociated adverse reactions is recommended if voriconazole is used sequentially after fluconazole (see section 4.5).
Danish: Monitorering for voriconazol-relaterede bivirkninger anbefales, hvis voriconazol anvendes sekventielt efter fluconazol (se pkt.
English: A relationship between plasma concentrations and age was observed.The safety profile of voriconazole in young and elderly patients was similar and, therefore, no dosage adjustment is necessary for the elderly (see section 4.2).
Danish: I de kliniske studier blev der ikke foretaget dosisjusteringer på baggrund af alder. Der blev observeret en sammenhæng mellem plasmakoncentrationer og alder. Voriconazols sikkerhedsprofil var ens hos både unge og ældre patienter, hvorfor en dosisjustering hos de ældre ikke er nødvendig (se pkt.
English: If it appears to be a dry powder you should constitute the oral suspension by following the instructions below.
Danish: Hvis den er et tørt pulver, skal det sammenblandes i henhold til vejledningen nedenfor.
English: The placeboadjusted mean maximum increases in QTc from baseline after 800, 1200 and 1600 mg of voriconazole were 5.1, 4.8, and 8.2 msec, respectively and 7.0 msec for ketoconazole 800 mg. No subject in any group had an increase in QTc of ≥ 60 msec from baseline.
Danish: De placebo-justerede gennemsnitlige maksimale stigninger i QTc i forhold til baseline efter 800 mg, 1200 mg og 1600 mg voriconazol var henholdsvis 5,1 msek., 4,8 msek.
English: squamous cell carcinoma*
Danish: planocellul ært karcinom*
English: Blood and lymphatic system disorders agranulocytosis pancytopenia, thrombocytopenia leukopenia, anaemia bone marrow failure, lymphadenopathy, eosinophilia disseminated intravascular coagulation
Danish: Blod og lymfesystem agranulocytose pancytopeni, trombocytopeni leukopeni, anæmi knoglemarvssvigt, lymfadenopati, eosinofili dissemineret intravaskulær koagulation
English: In an oral single-dose (200 mg) study in subjects with normal renal function and mild (creatinine clearance 41-60 ml/min) to severe (creatinine clearance <20 ml/min) renal impairment, the pharmacokinetics of voriconazole were not significantly affected by renal impairment.
Danish: I et oralt enkeltdosisstudie (200 mg) hos patienter med normal nyrefunktion og mild (kreatinin clearance 41-60 ml/min) til svært nedsat nyrefunktion (kreatinin clearance < 20 ml/min) var voriconazols farmakokinetik ikke signifikant påvirket af nedsat nyrefunktion.
English: In an oral single-dose (200 mg) study in subjects with normal renal function and mild (creatinine clearance 41-60 ml/min) to severe (creatinine clearance < 20 ml/min) renal impairment, the pharmacokinetics of voriconazole were not significantly affected by renal impairment.
Danish: I et oralt enkeltdosisstudie (200 mg) hos patienter med normal nyrefunktion og mild (kreatinin clearance 41-60 ml/min) til svært nedsat nyrefunktion (kreatinin clearance <20 ml/min) var voriconazols farmakokinetik ikke signifikant påvirket af nedsat nyrefunktion.
English: In an oral multiple-dose study, AUCτ was similar in subjects with moderate hepatic cirrhosis (Child-Pugh B) given a maintenance dose of 100 mg twice daily and subjects with normal hepatic function given 200 mg twice daily.
Danish: I et oralt flerdosisstudie var AUC ens for personer med moderat levercirrose (Child-Pugh klasse B), der fik en vedligeholdelsesdosis på 100 mg 2 gange dagligt, og personer med normal leverfunktion, der fik 200 mg 2 gange dagligt.
English: The most commonly reported adverse reactions were visual impairment, pyrexia, rash, vomiting, nausea, diarrhoea, headache, peripheral oedema, liver function test abnormal, respiratory distress and abdominal pain.
Danish: De hyppigst rapporterede bivirkninger var synsnedsættelse, pyreksi, udslæt, opkastning, kvalme, diarré, hovedpine, perifere ødemer, abnorme leverfunktionstests, åndedrætsbesvær og abdominalsmerter.
English: Patients being treated with voriconazole are likely to be treated concomitantly with nephrotoxic medicinal products and have concurrent conditions that may result in decreased renal function (see section 4.8).
Danish: Patienter, der behandles med voriconazol, vil ofte samtidig være i behandling med nefrotoksisk medicin og vil have samtidige tilstande, der kan medføre nedsat nyrefunktion (se pkt.
English: Coadministration with sirolimus since voriconazole is likely to increase plasma concentrations of sirolimus significantly (see section 4.5).
Danish: Samtidig administration af sirolimus, da voriconazol sandsynligvis vil øge plasmakoncentrationer af sirolimus signifikant (se pkt.
English: When voriconazole is discontinued, tacrolimus levels must be carefully monitored and the dose increased as necessary.
Danish: Når voriconazole seponeres skal tacrolimus-koncentrationerne monitoreres nøje og dosis om nødvendigt justeres.
English: Unscrew the syringe and discard the vial adaptor and vial.
Danish: Afmontér sprøjten og kassér adapteren og hætteglasset.
English: Use only items provided in the box with VFEND powder and solvent for solution for infusion in the preparation of the infusion.
Danish: Anvend kun det udstyr, der er vedlagt i pakken med VFEND pulver og solvens til infusionsvæske, opløsning til klargøring af infusionsvæsken.
English: The powder is reconstituted with either 19 ml of water for injections or 19 ml of 9 mg/ml (0.9%) Sodium Chloride for Infusion to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml of voriconazole.
Danish: Pulveret skal rekonstitueres med enten 19 ml vand til injektionsvæsker eller 19 ml 9 mg/ml (0,9%) natriumchlorid infusionsvæske for at opnå et klart koncentrat, hvorfra der kan trækkes et volumen på 20 ml, der indeholder 10 mg/ml voriconazol.
English: 2 film-coated tablets 30 film-coated tablets 100 film-coated tablets
Danish: 2 filmovertrukne tabletter 30 filmovertrukne tabletter 100 filmovertrukne tabletter
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE ELLER, NÅR EN SÅDAN IKKE FINDES, PÅ DEN INDRE EMBALLAGE
English: In an independent published study, Fentanyl AUC0-  1.34-fold
Danish: I et uafhængigt publiceret studie, Fentanyl AUC   1,34 gange
English: • Discard the VFEND vial if the vacuum does not pull the diluent into the vial.
Danish: • Hætteglasset med VFEND kasseres, hvis vakuum ikke kan trække fortyndingsmidlet op i hætteglasset.
English: Prednisolone Cmax  11% Prednisolone AUC0-  34%
Danish: Prednisolon Cmax  11% Prednisolon AUC   34%
English: Omeprazole Cmax  116% Omeprazole AUC  280% Voriconazole Cmax  15% Voriconazole AUC  41%
Danish: Omeprazol Cmax  116% Omeprazol AUC  280% Voriconazol Cmax  15% Voriconazol AUC  41%
English: In an overdose, haemodialysis may assist in the removal of voriconazole from the body.
Danish: Ved overdosering kan hæmodialyse muligvis medvirke til af fjerne voriconazol fra kroppen.
English: Although not studied, carbamazepine and long-acting barbiturates are likely to significantly decrease plasma voriconazole concentrations.
Danish: Selvom det ikke er undersøgt er det sandsynligt, at carbamazepin og langtidsvirkende benzodiazepiner kan nedsætte voriconazol plasmakoncentrationer signifikant.
English: The shelf life of the constituted suspension is 14 days.
Danish: Opbevaringstid efter færdigblanding er 14 dage.
English: Dose reduction in oxycodone and other long-acting opiates metabolized by CYP3A4 (e.g., hydrocodone) should be considered.
Danish: Dosisreduktion af oxycodon og andre langtidsvirkende opiater, der metaboliseres af CYP3A4 (f.eks. hydrocodon) bør overvejes.
English: In vitro studies showed that voriconazole is metabolised by the hepatic cytochrome P450 isoenzymes CYP2C19, CYP2C9 and CYP3A4.
Danish: In vitro studier har vist, at voriconazol metaboliseres via leverens CYP-isoenzymer CYP2C19, CYP2C9 og CYP3A4.
English: Coadministration of voriconazole and high doses of ritonavir (400 mg and above BID) is contraindicated (see section 4.3).
Danish: Samtidig administration af voriconazol og høj-dosis ritonavir (400 mg og derover BID) er kontraindiceret (se pkt.
English: Critical Instructions for safe and effective use of infusion kit Aseptic procedures will be followed during kit preparation Bag must be inverted when the reconstituted Voriconazole is added
Danish: Aseptiske procedurer skal følges under tilberedning Infusionsposen skal vendes, når det rekonstituerede voriconazol er tilsat
English: Efavirenz (CYP450 inducer; CYP3A4 inhibitor and substrate) When voriconazole is coadministered with efavirenz the dose of voriconazole should be increased to 400 mg every 12 hours and the dose of efavirenz should be decreased to 300 mg every 24 hours (see sections 4.2, 4.3 and 4.5).
Danish: Efavirenz (CYP-induktor; CYP3A4-hæmmer og -substrat) Når voriconazol anvendes samtidigt med efavirenz, bør dosis af voriconazol øges til 400 mg hver 12. time, og efavirenz-dosis bør nedsættes til 300 mg hvert 24. time (se pkt.
English: In patients with moderate to severe renal dysfunction (creatinine clearance < 50 ml/min), accumulation of the intravenous vehicle, SBECD, occurs.
Danish: Der kan hos patienter med moderat til svær nyreinsufficiens (kreatininclearance < 50 ml/min) ses akkumulering af hjælpestoffet SBECD i intravenøst VFEND.
English: Excipient: sulfobutylether beta cyclodextrin sodium.
Danish: Hjælpestof: Sulfobutylether beta cyclodextrinnatrium.
English: Fertility In an animal study, no impairment of fertility was demonstrated in male and female rats (see section 5.3).
Danish: Fertilitet Dyrestudier viste ikke nedsat fertilitet hos på han- og hunrotter (se pkt.
English: In the same study, no significant differences in Cmax and AUCτ were observed between healthy elderly males and healthy elderly females (≥65 years).
Danish: I samme studie blev der ikke observeret signifikante ændringer i Cmax og AUC mellem raske, ældre mænd og raske, ældre, kvinder ( 65 år).
English: Dermatological reactions were very common in patients treated with voriconazole in clinical trials, but these patients had serious underlying diseases and were receiving multiple concomitant medicinal products.
Danish: Dermatologiske reaktioner var meget almindelige hos patienter behandlet med voriconazol i kliniske studier, men disse patienter havde alvorlige tilgrundliggende sygdomme, og fik samtidig behandling med anden medicin.
English: Sodium Chloride 9 mg/ml (0.9%) Solution for Injection Compound Sodium Lactate Intravenous Infusion 5% Glucose and Lactated Ringer's Intravenous Infusion 5% Glucose and 0.45% Sodium Chloride Intravenous Infusion 5% Glucose Intravenous Infusion 5% Glucose in 20 mEq Potassium Chloride Intravenous Infusion 0.45% Sodium Chloride Intravenous Infusion 5% Glucose and 0.9% Sodium Chloride Intravenous Infusion
Danish: Natriumchlorid 9 mg/ml (0,9%) injektionsvæske, opløsning Natriumlactatforbindelse infusionsvæske 5% glucose og Ringer-Lactat infusionsvæske 5% glucose og 0,45% natriumchlorid infusionsvæske 5% glucose infusionsvæske
English: Developed proven or probable IFI to day 100
Danish: Udviklet påvist eller sandsynlig invasiv svampeinfektion til dag
English: A measuring cup (graduated to indicate 23 ml), 5 ml oral syringe and a press-in bottle adaptor are also provided.
Danish: I pakningen findes et målebæger (med markering der angiver 23 ml), en 5 ml doseringssprøjte og en flaskeadapter til at trykke ned i flaskehalsen.
English: VFEND 200 mg film-coated tablets EU/1/02/212/013-024
Danish: VFEND 200 mg filmovertrukne tabletter EU/1/02/212/013-024
English: Depending on your response to treatment, your doctor may increase the daily dose to 300 mg twice a day.
Danish: Afhængigt af hvordan behandlingen virker, vil lægen måske øge dosis til 300 mg 2 gange dagligt.
English: Inflammation of certain internal organs- pancreas and duodenum, swelling and inflammation of the tongue
Danish: • Betændelse i visse indre organer, bugspytkirtlen og tolvfingertarmen, hævelse og betændelsestilstand i tungen
English: EU/1/02/212/010 2 film-coated tablets EU/1/02/212/011 30 film-coated tablets EU/1/02/212/012 100 film-coated tablets
Danish: EU/1/02/212/010 2 filmovertrukne tabletter EU/1/02/212/011 30 filmovertrukne tabletter EU/1/02/212/012 100 filmovertrukne tabletter
English: Hang the infusion bag.
Danish: Infusionsposen hænges op.
English: Each bag contains 50 ml of sodium chloride 0.9% in Water for Injections.
Danish: Hver infusionspose indeholder 50 ml natriumchlorid 9 mg/ml (0,9%) i vand til injektionsvæsker.
English: Other Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) (e.g., delavirdine, nevirapine) [CYP3A4 substrates, inhibitors or CYP450 inducers]
Danish: Andre non-nucleosid reverse transcriptase-hæmmer (NNRTI) (f.eks. delavirdin, nevirapin) [CYP3A4-substrater, -hæmmere eller CYP-induktorer]
English: • It is recommended that a standard 20 ml (non-automated) syringe be used to ensure that the exact amount (19.0 ml) of Water for Injections or of 9 mg/ml (0.9%) Sodium Chloride for Infusion is dispensed.
Danish: • Det anbefales, at anvende en standard 20 ml (ikke-automatiseret) sprøjte for at sikre, at det præcise volumen (19,0 ml) vand til injektionsvæsker eller natriumchlorid infusionsvæske (9 mg/ml (0,9%)) tilsættes.
English: • VFEND powder for solution for infusion needs to first be reconstituted with either 19 ml of Water for Injections or 19 ml of 9 mg/ml (0.9%) Sodium Chloride for Infusion to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml voriconazole.
Danish: • VFEND pulver til infusion, opløsning skal først rekonstitueres med enten 19 ml vand til injektionsvæsker eller 19 ml 9 mg/ml (0,9%) natriumchlorid infusionsvæske for at opnå et klart koncentrat, hvorfra der kan trækkes et volumen på 20 ml, der indeholder 10 mg/ml voriconazol.
English: PVC / Aluminium/PVC/PVDC blister in cartons of 2, 10, 14, 20, 28, 30, 50, 56 or 100 film-coated tablets.
Danish: PVC/Aluminium/PVC/PVDC blisterkort i kartoner med 2, 10, 14, 20, 28, 30, 50, 56 eller 100 filmovertrukne tabletter.
English: VFEND 200 mg powder and solvent for solution for infusion: VFEND powder and solvent for solution for infusion is available in a box containing:
Danish: VFEND 200 mg pulver og solvens til infusionsvæske, opløsning: VFEND pulver og solvens til infusionsvæske, opløsning leveres i en æske indeholdende:
English: VFEND contains sodium
Danish: VFEND indeholder natrium
English: 5a Invert the infusion bag and screw the syringe into Blue port.
Danish: 5a Vend infusionsposen på hovedet og monter sprøjten på den blå port. 5b Tøm indholdet af sprøjten i posen.
English: Other HIV Protease Inhibitors (e.g., saquinavir, amprenavir and nelfinavir) [CYP3A4 substrates and inhibitors]
Danish: Andre hiv-proteasehæmmere (f.eks. saquinavir, amprenavir og nelfinavir) [CYP3A4-substrater oghæmmere]
English: VFEND requires reconstitution and dilution (see section 6.6) prior to administration as an intravenous infusion.
Danish: 6.6) før administration som intravenøs infusion.
English: If patient is unable to tolerate treatment at a higher dose, reduce the oral dose by 50 mg steps to the 200 mg twice daily (or 100 mg twice daily for patients less than 40 kg) maintenance dose.
Danish: Hvis patienten ikke kan tåle behandling med den højere dosis, reduceres den orale dosis med 50 mg ad gangen til en vedligeholdelsesdosis på 200 mg 2 gange dagligt (eller 100 mg 2 gange dagligt hos patienter med en legemsvægt under 40 kg).
English: It is recommended that a standard 20 ml (non-automated) syringe be used to ensure that the exact amount (19.0 ml) of water for injections or (9 mg/ml [0.9%]) Sodium Chloride for Infusion is dispensed.
Danish: Det anbefales at anvende en standard 20 ml (ikke automatiseret) sprøjte for at sikre, at det præcise volumen (19,0 ml) vand til injektionsvæsker ellernatriumchlorid infusionsvæske (9 mg/ml (0,9%)) tilsættes.
English: EU/1/02/212/022 2 film-coated tablets EU/1/02/212/023 30 film-coated tablets EU/1/02/212/024 100 film-coated tablets
Danish: EU/1//02/212/022 2 filmovertrukne tabletter EU/1//02/212/023 30 filmovertrukne tabletter EU/1//02/212/024 100 filmovertrukne tabletter
English: 1 vial of VFEND powder for solution for infusion (single use vial) 1 overwrap
Danish: 1 hætteglas med VFEND pulver til infusionsvæske, opløsning (til engangsbrug) 1 folieomslag
English: Ritonavir Cmax  25% Ritonavir AUC 13% Voriconazole Cmax  24% Voriconazole AUC  39%
Danish: Ritonavir Cmax  25% Ritonavir AUC 13% Voriconazol Cmax  24% Voriconazol AUC  39%
English: Other oral coumarins (e.g., phenprocoumon, acenocoumarol) [CYP2C9 and CYP3A4 substrates]
Danish: Andre orale coumariner (f.eks. phenprocoumon, acenocoumarol) [CYP2C9- og CYP3A4substrater]
English: Breathing difficulties
Danish: • Vejrtrækningsbesvær
English: Solvent for solution for infusion: Sodium chloride 0.9% in Water for Injections
Danish: Solvens til infusionsvæske, opløsning: 0,9 % natriumchlorid i vand til injektionsvæsker
English: Rifabutin (Potent CYP450 inducer)
Danish: Rifabutin (potent CYP-induktor)
English: Efavirenz (a non-nucleoside reverse transcriptase inhibitor) [CYP450 inducer; CYP3A4 inhibitor and substrate]
Danish: Efavirenz (en non-nukleosid reverse transcriptase-hæmmer) [CYP-induktor; CYP3A4hæmmer og -substrat]
English: • Ergot alkaloids (e.g., ergotamine, dihydroergotamine; used for migraine)
Danish: • Sekalealkaloider (f.eks. ergotamin, dihydroergotamin, som bruges mod migræne)
English: When voriconazole is discontinued, ciclosporin levels must be carefully monitored and the dose increased as necessary.
Danish: Når voriconazol seponeres skal ciclosporin-koncentrationerne monitoreres nøje og dosis om nødvendigt justeres.
English: Efavirenz Cmax  38% Efavirenz AUC  44% Voriconazole Cmax  61% Voriconazole AUC  77%
Danish: Efavirenz Cmax  38% Efavirenz AUC  44% Voriconazol Cmax  61% Voriconazol AUC  77%
English: Fluconazole (200 mg QD) [CYP2C9, CYP2C19 and CYP3A4 inhibitor]
Danish: Fluconazol (200 mg QD) [CYP2C9-, CYP2C19- og CYP3A4-hæmmer]
English: Remove the cap. Press the bottle adaptor into the neck of the bottle (as shown on figure below).
Danish: Tryk flaskeadaptoren ned i flaskehalsen som vist på tegningen nedenfor.
English: In clinical studies, response to voriconazole in C. krusei infections was similar to C. albicans, C. parapsilosis and C. tropicalis.
Danish: I kliniske studier svarede responset på voriconazol hos patienter med infektion med C. krusei til responset ved C. albicans, C. parapsilosis og C. tropicalis.
English: When voriconazole treatment is stopped, the initial dose of efavirenz should be restored (see section 4.2 and 4.4).
Danish: Når voriconazolbehandling standses bør initialdosis af efavirenz genoptages (se pkt.
English: Cardiac disorders arrhythmia supraventricular, tachycardia, bradycardia ventricular fibrillation, ventricular extrasystoles, ventricular tachycardia, electrocardiogram QT prolonged, supraventricular tachycardia torsades de pointes, atrioventricular block complete, bundle branch block, nodal rhythm
Danish: Hjerte supraventrikulær arytmi, takykardi, bradykardi ventrikulær flimren, ventrikulære ekstrasystoler, ventrikulær torsades de pointes, komplet AV-blok, grenblok, nodal arytmi
English: Ritonavir (protease inhibitor) [potent CYP450 inducer; CYP3A4 inhibitor and substrate]
Danish: Ritonavir (proteasehæmmer) [potent CYP-induktor; CYP3A4hæmmer og -substrat]
English: It is recommended that all patients, including children, avoid exposure to direct sunlight during VFEND treatment and use measures such as protective clothing and sunscreen with high sun protection factor (SPF).
Danish: Det anbefales, at alle patienter, herunder også børn, undgår udsættelse for sollys under VFEND-behandling.
English: Store in a refrigerator (2°C - 8°C).
Danish: Opbevares ved 2°C-8°C (i køleskab).
English: Omeprazole (40 mg QD) [CYP2C19 inhibitor; CYP2C19 and CYP3A4 substrate]
Danish: Omeprazol (40 mg QD) [CYP2C19-hæmmer; CYP2C19og CYP3A4-substrat]
English: Voriconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems.
Danish: Det er vist, at voriconazol er mere selektiv for fungale CYP-enzymsystemer end for forskellige mammale CYP-enzymsystemer.
English: Once reconstituted, VFEND should be used immediately, but if necessary may be stored for up to 24 hours at 2°C - 8°C (in a refrigerator).
Danish: VFEND skal bruges umiddelbart efter rekonstituering, men hvis nødvendigt kan den rekonstituerede opløsning opbevares op til 24 timer ved 2°C til 8°C (i køleskab).
English: VFEND contains sucrose
Danish: VFEND indeholder saccharose
English: • Health Care Professional (HCP) Question and Answer Brochure for Phototoxicity, SCC and Hepatic toxicity; - Advises HCPs on the risks of phototoxicity, skin SCC and liver toxicity associated with voriconazole use.
Danish: • Brochure med spørgsmål og svar til læger og sundhedspersonale om fototoksicitet, planocellulært karcinom og hepatisk toksicitet; - Vejlede læger og sundhedspersonale om de risici for fototoksicitet, planocellulært hudkarcinom og levertoksicitet, der er relateret til anvendelse af voriconazol.