FrancophonIA/ELRC3.0 huggingface dataset:
English: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Bevespi Aerosphere.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku ili ljekarniku za savjet prije nego primijenite Bevespi Aerosphere.
English: Do not use this medicine after the expiry date which is stated on the carton, pouch and pressurised container after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji, vrećici i spremniku pod tlakom iza oznake „EXP”.
English: • medicines called beta-blockers that may be used to treat high blood pressure or other heart problems (such as atenolol or propranolol) or to treat glaucoma (such as timolol)
Croatian: • lijekove koji se zovu beta-blokatori, a mogu se koristiti za liječenje visokog krvnog tlaka ili drugih srčanih tegoba (poput atenolola ili propranolola) ili za liječenje glaukoma (poput timolola)
English: In the airways, it exhibits pharmacological effects through inhibition of the M3 receptor at the smooth muscle leading to bronchodilation.
Croatian: U dišnim putovima ostvaruje farmakološke učinke inhibicijom M3 receptora u glatkim mišićima, koja dovodi do bronhodilatacije.
English: An overdose of Bevespi Aerosphere may lead to exaggerated anticholinergic and/or β2-adrenergic signs and symptoms, the most frequent of which include blurred vision, dry mouth, nausea, muscle spasm, tremor, headache, palpitations and systolic hypertension.
Croatian: Predoziranje lijekom Bevespi Aerosphere može dovesti do preizraženih antikolinergičkih i/ili β2-adrenergičkih znakova i simptoma, od kojih su najčešći zamagljen vid, suha usta, mučnina, mišićni grčevi, tremor, glavobolja, palpitacije i sistolička hipertenzija.
English: Turn the actuator upside down and rinse the actuator again through the mouthpiece for about 30 seconds (See Figure 16).
Croatian: Preokrenite aktivator i ponovno ga isperite tako da voda prolazi kroz nastavak za usta približno 30 sekundi (pogledajte Sliku 16).
English: PINNACLE 4 used TDI.
Croatian: U ispitivanju PINNACLE 4 koristio se TDI.
English: It is very important to keep your inhaler clean so that medicine does not build-up and block the spray through the mouthpiece (See Figure 14).
Croatian: Vrlo je važno da inhalator održavate čistim kako ne bi došlo do nakupljanja lijeka i začepljenja nastavka za usta (pogledajte Sliku 14).
English: Step 5: While breathing in deeply and slowly, press down on the centre of the dose indicator until the pressurised container stops moving in the actuator and a puff of medicine has been released (See Figure 10).
Croatian: 5. korak: Dok duboko i polako udišete, pritišćite središnji dio pokazivača doze dok se spremnik pod tlakom ne prestane pomicati u aktivatoru i dok se ne otpusti količina lijeka za jedan udisaj (pogledajte Sliku 10).
English: These are known pharmacological manifestations seen after administration of high doses of adrenoceptor agonists.
Croatian: Radi se o poznatim farmakološkim manifestacijama vidljivima nakon primjene visokih doza agonista -adrenoreceptora.
English: Step 6: Let the actuator air-dry overnight (See Figure 17).
Croatian: 6. korak: Pustite da se aktivator osuši na zraku tijekom noći (pogledajte Sliku 17).
English: dizziness and nausea are common side effects which may occur.
Croatian: Međutim, omaglica i mučnina česte su nuspojave koje se mogu pojaviti.
English: To get adequate lung deposition of the active substances actuation must be co-ordinated with inhalation.
Croatian: Kako bi se postigla odgovarajuća depozicija djelatnih tvari u plućima, aktivacija inhalatora mora biti usklađena s inhalacijom.
English: It is unlikely that Bevespi Aerosphere administered at the recommended dose will affect fertility in humans.
Croatian: Nije vjerojatno da će Bevespi Aerosphere primijenjen u preporučenoj dozi utjecati na plodnost ljudi.
English: EXP To be used within 3 months of opening the pouch.
Croatian: EXP Upotrijebiti u roku od 3 mjeseca nakon otvaranja vrećice.
English: However dizziness and nausea are common side effects which should be taken into account when driving or using machines.
Croatian: Međutim, omaglica i mučnina česte su nuspojave koje treba uzeti u obzir kod upravljanja vozilima i rada sa strojevima.
English: Glycopyrronium has similar affinity to the subtypes of muscarinic receptors M1 to M5.
Croatian: Glikopironij ima sličan afinitet za podtipove muskarinskih receptora M1 do M5.
English: Pressurised inhalation, suspension.
Croatian: Stlačeni inhalat, suspenzija.
English: What Bevespi Aerosphere is and what it is used for
Croatian: Što je Bevespi Aerosphere i za što se koristi
English: In-vitro studies indicate the glycopyrronium does not inhibit any subtype of cytochrome P450 and that there is no induction of CYP1A2, 2B6, or 3A4.
Croatian: Ispitivanja in vitro ukazuju na to da glikopironij ne inhibira nijedan podtip citokroma P450 te da ne inducira CYP1A2, 2B6 ni 3A4.
English: If β-adrenergic blockers are required (including eye drops), cardioselective β-adrenergic blockers are preferred, although they should also be administered with caution.
Croatian: Ako je primjena blokatora β-adrenoreceptora (uključujući kapi za oči) neophodna, prednost se daje kardioselektivnim blokatorima β-adrenoreceptora, premda i njih treba primjenjivati uz oprez.
English: Figure 1 - Mean Change from Baseline in FEV1 over Time on Day 1 and at Week 12
Croatian: Slika 1 - Srednja vrijednost promjene početne vrijednosti FEV1 tijekom vremena 1. dana i u 12. tjednu
English: Bevespi Aerosphere is used regularly for long-term treatment of COPD.
Croatian: Bevespi Aerosphere koristi se redovito za dugoročno liječenje KOPB-a.
English: o Throw away the pouch and the drying packet.
Croatian: o Bacite vrećicu i sredstvo za sušenje.
English: • Repeat the priming steps 3 more times (See Figure 4 and Figure 5).
Croatian: • Ponovite korake za pripremu inhalatora još 3 puta (pogledajte Sliku 4 i Sliku 5).
English: The individual studies were not specifically designed to evaluate the effect of treatments on COPD exacerbations and patients were withdrawn from the studies if a severe exacerbation or more than 2 moderate exacerbations occurred.
Croatian: Pojedinačna ispitivanja nisu bila posebno dizajnirana za ocjenu učinka liječenja na egzacerbacije KOPB-a te su bolesnici u slučaju teške ili više od 2 umjerene egzacerbacije bili povučeni iz ispitivanja.
English: What Bevespi Aerosphere looks like and contents of the pack
Croatian: Kako Bevespi Aerosphere izgleda i sadržaj pakiranja
English: Do not use the inhaler if the drying agent has leaked out of its packet.
Croatian: Nemojte upotrijebiti inhalator ako je sredstvo za sušenje iscurilo iz svog pakiranja.
English: Compatibility with the Aerochamber Plus Flow-Vu spacer device has been demonstrated (see section 5.2).
Croatian: Dokazana je kompatibilnost s komorom za inhaliranje Aerochamber Plus Flow-Vu (vidjeti dio 5.2).
English: The medicine prevents the tightening of the muscles around the airways, making it easier for air to get in and out of the lungs.
Croatian: Lijek sprječava stezanje mišića oko dišnih putova, olakšavajući tako ulazak i izlazak zraka iz pluća.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Bevespi Aerosphere in all subsets of the paediatric population in COPD (see section 4.2 for information on paediatric use).
Croatian: Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja lijeka Bevespi Aerosphere u svim podskupinama pedijatrijske populacije u KOPB-u (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
English: • The dose indicator display window will move after every 10 puffs.
Croatian: • Prozorčić za prikaz doze pomaknut će se nakon svakih 10 udisaja.
English: • Press down firmly on the centre of the dose indicator until the pressurised container stops moving in the actuator.
Croatian: • Čvrsto pritisnite središnji dio pokazivača doze dok se spremnik pod tlakom ne prestane pomicati u aktivatoru.
English: If you have used more Bevespi Aerosphere than you should, talk to a doctor or pharmacist immediately.
Croatian: Ako ste primijenili više lijeka Bevespi Aerosphere nego što ste trebali, odmah se obratite liječniku ili ljekarniku.
English: Write the date the pouch is opened on the inhaler label in the space provided.
Croatian: Napišite datum otvaranja vrećice na za to predviđeno mjesto na naljepnici inhalatora.
English: The primary metabolism of formoterol is by direct glucuronidation and by O-demethylation followed by conjugation to inactive metabolites.
Croatian: Formoterol se prvenstveno metabolizira izravnom glukuronidacijom i O-demetilacijom, nakon kojih slijedi konjugacija u neaktivne metabolite.
English: Formoterol causes direct relaxation of airway smooth muscle as a consequence of the increase in cyclic AMP through activation of adenylate cyclase.
Croatian: Formoterol uzrokuje izravno opuštanje glatkih mišića dišnih putova koje je posljedica povećanja razine cikličkog adenozin monofosfata (AMP) uslijed aktivacije adenilat ciklaze.
English: If you use more Bevespi Aerosphere than you should
Croatian: Ako primijenite više lijeka Bevespi Aerosphere nego što ste trebali
English: Bevespi Aerosphere should not be used to treat asthma.
Croatian: Bevespi Aerosphere ne smije se koristiti za liječenje astme.
English: Do not press down too hard on the pressurised container.
Croatian: Nemojte prejako pritiskati spremnik pod tlakom.
English: No significant effects attributable to glycopyrronium were seen.
Croatian: Nisu opaženi značajni učinci koji bi se mogli pripisati glikopironiju.
English: A lung deposition study with Bevespi Aerosphere conducted in healthy volunteers demonstrated that on average 38% of the nominal dose is deposited into the lung.
Croatian: Ispitivanje u kojem se ocjenjivala depozicija lijeka Bevespi Aerosphere u plućima zdravih dobrovoljaca pokazalo je da se u plućima deponira prosječno 38% nominalne doze.
English: Renal function was found not to affect exposure to formoterol.
Croatian: Utvrđeno je da funkcija bubrega ne utječe na izloženost formoterolu.
English: As a consequence of the differential density of muscarinic receptors and β2-adrenoceptors in the central and peripheral airways of the lung, muscarinic antagonists are more effective in relaxing central airways, and β2-adrenergic agonists are more effective in relaxing peripheral airways; relaxation of both central and peripheral airways with combination treatment may contribute to its beneficial effects on lung function.
Croatian: Kao posljedica različite gustoće muskarinskih receptora i β2-adrenoceptora u središnjim i perifernim dišnim putovima pluća, muskarinski antagonisti učinkovitiji su u opuštanju središnjih dišnih putova, dok su agonisti β2-adrenoreceptora učinkovitiji u opuštanju perifernih dišnih putova; opuštanje i središnjih i perifernih dišnih putova kombiniranom terapijom može pridonijeti pozitivnom učinku liječenja na plućnu funkciju.
English: Studies in rats have shown adverse effects on fertility only at dose levels higher than the maximum human exposure to formoterol (see section 5.3).
Croatian: Ispitivanja na štakorima pokazala su štetne učinke na plodnost samo kod primjene doza kojima se postiže izloženost veća od maksimalne razine izloženosti formoterolu kod ljudi (vidjeti dio 5.3).
English: Pressurised inhalation, suspension (pressurised inhalation).
Croatian: Stlačeni inhalat, suspenzija (stlačeni inhalat).
English: These include medicines for the treatment of: o depression (such as monoamine oxidase inhibitors or tricyclic antidepressants), o bacterial infections (such as erythromycin, clarithromycin, telithromycin), o allergic reactions (anti-histamines).
Croatian: To uključuje lijekove za liječenje: o depresije (poput inhibitora monoaminooksidaze ili tricikličkih antidepresiva) o bakterijskih infekcija (poput eritromicina, klaritromicina, telitromicina) o alergijskih reakcija (antihistaminici)
English: Bevespi Aerosphere is available in packs containing 1 inhaler with 120 puffs and in multipacks comprising 3 inhalers, each containing 120 puffs.
Croatian: Bevespi Aerosphere dostupan je u pakiranjima s 1 inhalatorom koji sadrži količinu lijeka za 120 udisaja i u višestrukim pakiranjima koja sadrže 3 inhalatora, od kojih svaki sadrži količinu lijeka za 120 udisaja.
English: β-adrenergic blockers β-adrenergic blockers (including eye drops) can weaken or inhibit the effect of β2-adrenergic agonists, such as formoterol.
Croatian: Blokatori β-adrenoreceptora (uključujući kapi za oči) mogu oslabiti ili inhibirati učinak agonista β2-adrenoreceptora, kao što je formoterol.
English: Dose adjustments are not necessary based on the effect of age, sex and weight on the pharmacokinetic parameters of glycopyrronium and formoterol.
Croatian: Nije potrebno prilagođavati dozu na temelju utjecaja dobi, spola i tjelesne težine na farmakokinetičke parametre glikopironija i formoterola.
English: Figure 2a 120 puffs
Croatian: Slika 2a 120 udisaja
English: Daily rescue Ventolin (inhalations/day)
Croatian: Dnevna primjena lijeka Ventolin za hitno ublažavanje simptoma (inhalacija/dan)
English: In-vitro studies indicate that formoterol does not inhibit the CYP450 enzymes at therapeutically relevant concentrations.
Croatian: Ispitivanja in vitro ukazuju na to da formoterol ne inhibira enzime citokroma P450 u terapijski značajnim koncentracijama.
English: Caution should also be exercised in patients with thyrotoxicosis or known or suspected prolongation of the QTc interval (see section 4.5).
Croatian: Potreban je oprez i kod bolesnika s tireotoksikozom ili poznatim ili suspektnim produljenjem QTc intervala (vidjeti dio 4.5).
English: To re-prime the inhaler, shake the inhaler well and press down on the centre of the dose indicator twice to release a total of 2 puffs into the air away from your face.
Croatian: Da biste ponovno pripremili inhalator, dobro ga protresite i dvaput pritisnite središnji dio pokazivača doze kako biste ispustili ukupno 2 udisaja u zrak, podalje od lica.
English: Inhalation of high doses of β2-adrenergic agonists may produce increases in plasma glucose.
Croatian: Inhalacija visokih doza agonista β2-adrenoreceptora može prouzročiti povišenje razine glukoze u plazmi.
English: The toxicity observed in studies with the combination of glycopyrronium and formoterol in dogs were associated with the pharmacological actions of formoterol, including effects mainly on the cardiovascular system, consisting of hyperaemia, tachycardia, arrhythmias and myocardial lesions.
Croatian: Toksičnost opažena kod primjene kombinacije glikopironija i formoterola u ispitivanjima na psima bila je povezana s farmakološkim djelovanjem formoterola, uključujući prvenstveno učinke na kardiovaskularni sustav, koji su obuhvaćali hiperemiju, tahikardiju, aritmije i lezije miokarda.
English: In clinical studies, paradoxical bronchospasm was not observed with Bevespi Aerosphere at its recommended dose.
Croatian: U kliničkim ispitivanjima nije opažen paradoksalni bronhospazam kod primjene lijeka Bevespi Aerosphere u preporučenoj dozi.
English: A population pharmacokinetic analysis of formoterol was performed based on data collected in a total of 437 subjects with COPD.
Croatian: Populacijska farmakokinetička analiza formoterola provedena je na temelju podataka prikupljenih kod ukupno 437 ispitanika s KOPB-om.
English: Following inhalation of the glycopyrronium and formoterol combination, the pharmacokinetics of each component was similar to those observed when each active substance was administered separately.
Croatian: Nakon inhaliranja kombinacije glikopironija i formoterola farmakokinetika pojedinačnih sastavnica bila je slična onoj opaženoj kod primjene svake djelatne tvari zasebno.
English: EU/1/18/1339/002 360 actuations (3 packs of 120 actuations)
Croatian: EU/1/18/1339/002 360 potisaka (3 inhalatora sa 120 potisaka)
English: If you do not use your Bevespi Aerosphere for more than 7 days or if exposed to low temperatures or is dropped:
Croatian: Ako niste koristili inhalator lijeka Bevespi Aerosphere dulje od 7 dana, ako je bio izložen niskim temperaturama ili ako je pao na pod:
English: A double dose should not be taken to make up for a forgotten dose.
Croatian: Ne smije se primijeniti dvostruka doza kako bi se nadoknadila propuštena doza.
English: If you are not sure of how to use Bevespi Aerosphere, contact your doctor or pharmacist.
Croatian: Ako niste sigurni kako primijeniti Bevespi Aerosphere, obratite se svom liječniku ili ljekarniku.
English: After IV administration of a 0.2 mg dose of radiolabelled glycopyrronium, 85% of the dose was recovered in urine 48 hours post dose and some of radioactivity was also recovered in bile.
Croatian: Nakon intravenske primjene doze od 0,2 mg radioaktivno označenog glikopironija, 85% doze pronađeno je u mokraći 48 sati nakon primjene, a dio radioaktivnosti pronađen je i u žuči.
English: If you do not use your Bevespi Aerosphere for more than 7 days, or if the inhaler is exposed to low temperatures or has been dropped, you will need to re-prime it before use.
Croatian: Ako niste koristili inhalator lijeka Bevespi Aerosphere dulje od 7 dana, ako je bio izložen niskim temperaturama ili ako je pao na pod, morate ga ponovno pripremiti prije uporabe.
English: It is not recommended to use Bevespi Aerosphere together with these medicines;
Croatian: Ne preporučuje se primjena lijeka Bevespi Aerosphere zajedno s tim lijekovima.
English: Bevespi Aerosphere should be used with caution in patients with severe cardiovascular disorders, such as ischaemic heart disease, tachyarrhythmias or severe heart failure.
Croatian: Bevespi Aerosphere potrebno je primjenjivati uz oprez kod bolesnika s teškim kardiovaskularnim poremećajima, kao što su ishemijska bolest srca, tahiaritmije ili teško zatajivanje srca.
English: If any of the above applies to you, or if you are not sure, talk to your doctor or pharmacist before using Bevespi Aerosphere.
Croatian: Ako se bilo što od gore navedenoga odnosi na Vas ili ako niste sigurni, razgovarajte sa svojim liječnikom ili ljekarnikom prije nego primijenite Bevespi Aerosphere.
English: When the patient inhales through the mouthpiece at the same time as actuating the inhaler, the substance will follow the inspired air into the airways.
Croatian: Kada bolesnik udahne kroz nastavak za usta istodobno aktivirajući inhalator, lijek zajedno s udahnutim zrakom ulazi u dišne putove.
English: Although no formal in-vivo drug interaction studies have been performed with Bevespi Aerosphere, studies indicate no clinical evidence of interactions when used concomitantly with other COPD medicinal products including short-acting β2-adrenergic bronchodilators, methylxanthines, and oral and inhaled steroids.
Croatian: Iako nisu provedena formalna ispitivanja interakcija lijeka Bevespi Aerosphere s drugim lijekovima in vivo, ispitivanja ne ukazuju ni na kakve kliničke dokaze interakcija kod istodobne primjene s drugim lijekovima za KOPB, uključujući kratkodjelujuće β2-adrenergičke bronhodilatatore, metilksantine te oralne i inhalacijske steroide.
English: Based on literature, and an in-vitro human hepatocyte study, metabolism plays a minor role in the overall elimination of glycopyrronium.
Croatian: Podaci iz literature i ispitivanja na ljudskim hepatocitima in vitro pokazuju da metabolizam igra malu ulogu u ukupnoj eliminaciji glikopironija.
English: Hypokalaemia β2-adrenergic agonists may produce significant hypokalaemia, which may increase the susceptibility to cardiac arrhythmias.
Croatian: Agonisti β2-adrenoreceptora mogu izazvati značajnu hipokalijemiju, koja može povećati sklonost srčanim aritmijama.
English: Estimated glomerular filtration rate (eGFR) varied from 30-196 mL/min, representing a range of moderate to no renal impairment.
Croatian: Procijenjena brzina glomerularne filtracije (engl. estimated glomerular filtration rate, eGFR) kretala se od 30 do 196 ml/min, što predstavlja raspon od umjerenog oštećenja do normalne funkcije bubrega.
English: Peak FEV1 (ml)
Croatian: Vršni FEV1 (ml)
English: Cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia, and extrasystoles)
Croatian: Srčani poremećaji tahikardija palpitacije srčane aritmije (fibrilacija atrija, supraventrikularna tahikardija i ekstrasistole)
English: The clinical development program for Bevespi Aerosphere included three 24-week, randomised, double-blind, placebo-controlled, parallel-group pivotal Phase III studies in 5,433 patients with moderate to very severe COPD (PINNACLE 1, PINNACLE 2 and PINNACLE 4).
Croatian: Program kliničkog razvoja lijeka Bevespi Aerosphere obuhvaćao je tri 24-tjedna, randomizirana, dvostruko slijepa, placebom kontrolirana, pivotalna ispitivanja faze III s paralelnim skupinama, provedena kod 5433 bolesnika s umjerenim do vrlo teškim KOPB-om (PINNACLE 1, PINNACLE 2 i PINNACLE 4).
English: Concomitant treatment with methylxanthine derivatives, steroids, or non-potassium-sparing diuretics may potentiate the possible initial hypokalaemic effect of β2-adrenergic agonists, therefore, caution is advised in their concomitant use (see section 4.4).
Croatian: Istodobno liječenje derivatima metilksantina, steroidima ili diureticima koji ne štede kalij može pojačati mogući početni hipokalijemijski učinak agonista β2-adrenoreceptora pa se kod njihove istodobne primjene preporučuje oprez (vidjeti dio 4.4).
English: • The pointer points to 120 after 10 puffs are delivered from Bevespi Aerosphere.
Croatian: • Indikator pokazuje na 120 nakon što se iz inhalatora lijeka Bevespi Aerosphere isporuči
English: Dose indicator display window
Croatian: Prozorčić za prikaz doze
English: Over the concentration range of 10-500 nmol/L, plasma protein binding of formoterol ranged from 46% to 58%.
Croatian: U rasponu koncentracija od 10 do 500 nmol/l vezivanje formoterola za proteine u plazmi kretalo se između 46% i 58%.
English: What Bevespi Aerosphere is and what it is used for What you need to know before you use Bevespi Aerosphere How to use Bevespi Aerosphere Possible side effects
Croatian: Što je Bevespi Aerosphere i za što se koristi Što morate znati prije nego počnete primjenjivati Bevespi Aerosphere
English: Step 4: Close your lips around the mouthpiece and tilt your head back, keeping your tongue below the mouthpiece (See Figure 9).
Croatian: Slika 8 4. korak: Usnama obujmite nastavak za usta i nagnite glavu unatrag, držeći jezik ispod nastavka za usta (pogledajte Sliku 9).
English: What you need to know before you use Bevespi Aerosphere
Croatian: Što morate znati prije nego počnete primjenjivati Bevespi Aerosphere
English: In animal studies formoterol and glycopyrronium, individually, have caused adverse effects in reproduction studies at very high doses/systemic exposure levels (see section 5.3).
Croatian: U ispitivanjima učinaka na reprodukciju kod životinja, formoterol i glikopironij, primijenjeni zasebno, uzrokovali su štetne učinke pri vrlo visokim dozama/razinama sistemske izloženosti (vidjeti dio 5.3).
English: The safety profile is characterised by anticholinergic and β2-adrenergic class effects related to the individual components of the combination.
Croatian: Sigurnosni profil karakteriziraju učinci skupine antikolinergika i agonista β2-adrenoreceptora povezani s pojedinačnim sastavnicama kombiniranog lijeka.
English: • Not use the inhaler if the drying agent, which is inside the foil pouch, has leaked out of its packet.
Croatian: • ne koristi inhalator ako je sredstvo za sušenje, koje se nalazi u vrećici od folije, iscurilo iz svog pakiranja.
English: Pressurised container
Croatian: Spremnik pod tlakom
English: Before you use Bevespi Aerosphere for the first time Before you use Bevespi Aerosphere for the first time, make sure that the pointer on the dose indicator is pointing to the right of the “120” inhalation mark in the dose indicator display window (See Figure
Croatian: Prije prve uporabe inhalatora lijeka Bevespi Aerosphere uvjerite se da indikator na pokazivaču doze pokazuje desno od oznake „120“ u prozorčiću za prikaz doze (pogledajte Sliku 1).
English: Step 7: Breathe out gently (See Figure 12).
Croatian: 7. korak: Nježno izdahnite (pogledajte Sliku 12).