FrancophonIA/ELRC3.0 huggingface dataset:
English: Forty-one percent of subjects (97/235) had nondetectable plasma HCV-RNA levels at week 4 and week 24 of therapy.
Croatian: Od ukupnog broja bolesnika, njih 41% (97/235) je imalo nemjerljivu HCV-RNK u plazmi u 4. i 24. tjednu liječenja.
English: - Do not shake, but gently turn the vial upside down until any powder at the top of the vial is dissolved.
Croatian: Nemojte tresti bočicu, nego je lagano preokrećite dok se ne otopi sav prašak na vrhu bočice.
English: This medicine is used in combination with ribavirin in children 3 years of age and older and adolescents who have not been treated previously for chronic hepatitis C.
Croatian: Ovaj lijek se u kombinaciji s ribavirinom koristi u djece dobi od 3 i više godina i adolescenata koji se ranije nisu liječili od kroničnog hepatitisa C.
English: All patients should be screened for hepatitis B before starting treatment with interferon for hepatitis C; patients co-infected with hepatitis B and C must then be monitored and managed according to current clinical guidelines.
Croatian: Prije početka liječenja interferonom zbog hepatitisa C, u svih je bolesnika potrebno napraviti probir na hepatitis B; bolesnike istodobno zaražene hepatitisom B i C tada se mora pratiti i liječiti sukladno važećim kliničkim smjernicama.
English: Psychiatric disorders Very common:
Croatian: Psihijatrijski poremećaji Vrlo često:
English: Interferon neutralising factor assays were performed on serum samples of patients who received ViraferonPeg in the clinical trial.
Croatian: Ispitivanja čimbenika koji neutraliziraju interferon provedena su na uzorcima seruma bolesnika koji su u kliničkom ispitivanju primali ViraferonPeg.
English: Preliminary data indicate that interferon alpha therapy may be associated with an increased rate of kidney graft rejection.
Croatian: Preliminarni podaci pokazuju da liječenje interferonom alfa može biti povezano s većom stopom odbacivanja bubrežnog presatka.
English: Clinical efficacy and safety - Adults Tritherapy with ViraferonPeg, ribavirin and boceprevir Refer to the SmPC for boceprevir.
Croatian: Djelotvornost i sigurnost u kliničkoj primjeni - odrasli Trojna terapija lijekom ViraferonPeg, ribavirinom i boceprevirom Pročitajte Sažetak opisa svojstava lijeka za boceprevir.
English: After administering the dose, discard the ViraferonPeg pre-filled pen (CLEARCLICK) and any unused solution contained in it.
Croatian: Nakon primjene doze, zbrinite ViraferonPeg napunjenu brizgalicu (CLEARCLICK) i neupotrebljenu otopinu koju sadržava.
English: Do not use this medicine after the expiry date which is stated on the carton, after EXP.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza "Rok valjanosti".
English: - a pre-filled pen (CLEARCLICK) - a needle ("Push-On Needle") - 2 alcohol swabs
Croatian: - napunjena brizgalica (CLEARCLICK) - igla (potisna igla) - 2 tupfera s alkoholom
English: - Insert the needle in the ampoule of solvent and withdraw the total amount of solvent.
Croatian: - Uvedite iglu u ampulu s otapalom i izvucite cijelu količinu otapala.
English: Patients with severe renal dysfunction (creatinine clearance 15-29 ml/minute) should have the starting dose of ViraferonPeg reduced by 50 %.
Croatian: Bolesnicima s teškim oštećenjem bubrežne funkcije (klirens kretinina 15-29 ml/min) treba smanjiti početnu dozu lijeka ViraferonPeg za 50%.
English: However, response rates in this trial were shown to be dependent also on the dose of ribavirin administered in combination with ViraferonPeg or interferon alfa-2b.
Croatian: Međutim, u ovom se ispitivanju pokazalo da stopa odgovora ovisi i o dozi ribavirina primijenjenoj u kombinaciji s lijekom ViraferonPeg ili interferonom alfa-2b.
English: SVR in patients with undetectable HCVRNA at treatment week 12
Croatian: SVR u bolesnika s nemjerljivom HCV-RNK u 12. tjednu liječenja
English: Do not inject into this site; withdraw the needle and repeat the procedure.
Croatian: Izvucite iglu i ponovite postupak.
English: SNAP!
Croatian: ŠKLJOC!
English: In the presence of thyroid dysfunction, ViraferonPeg treatment may be continued if TSH levels can be maintained in the normal range by medicine.
Croatian: U slučaju poremećaja rada štitnjače liječenje lijekom ViraferonPeg može se nastaviti ako se koncentracija TSH-a može lijekovima održavati unutar granica normale.
English: Subjects treated with ViraferonPeg showed mild dose-related elevations in body temperature.
Croatian: Ispitanici liječeni lijekom ViraferonPeg pokazali su blag, dozi sukladan porast tjelesne temperature.
English: As with interferon alfa-2b, adult patients with a history of congestive heart failure, myocardial infarction and/or previous or current arrhythmic disorders, receiving ViraferonPeg therapy require close monitoring.
Croatian: Kao i kod liječenja interferonom alfa-2b, odrasle bolesnike s kongestivnim zatajenjem srca, infarktom miokarda i/ili prethodnim ili postojećim poremećajima srčanog ritma u anamnezi mora se pomno nadzirati tijekom liječenja lijekom ViraferonPeg.
English: At the ViraferonPeg 1.5 µg/kg plus ribavirin dose, sustained virologic response rates were lower in patients with cirrhosis, in patients with normal ALT levels, in patients with a baseline viral load > 600,000 IU/ml, and in patients > 40 years old.
Croatian: Kod primjene lijeka ViraferonPeg u dozi od 1,5 µg/kg uz ribavirin, stopa trajnog virološkog odgovora bila je manja u bolesnika s cirozom, bolesnika s normalnim koncentracijama ALT-a, bolesnika s početnim virusnim opterećenjem > 600 000 IU/ml i bolesnika starijih od 40 godina.
English: Pneumonia, ascariasis, enterobiasis, herpes zoster, cellulitis, urinary tract infection, gastroenteritis Blood and lymphatic system disorders Very common:
Croatian: pneumonija, askarijaza, enterobijaza, herpes zoster, celulitis, infekcija mokraćnog sustava, gastroenteritis Poremećaji krvi i limfnog sustava Vrlo često:
English: Tolbutamide (CYP2C9 substrate)
Croatian: Tolbutamid (supstrat CYP2C9)
English: Patients who were HCV-RNA negative at treatment week 12 continued treatment for 48 weeks and were followed for 24 weeks post-treatment.
Croatian: Bolesnici koji su imali negativan nalaz HCV-RNK u 12. tjednu liječenja nastavili su s liječenjem tijekom 48 tjedana te ih se pratilo još 24 tjedna nakon završetka liječenja.
English: Because of marked inter-subject variability in interferon pharmacokinetics, it is recommended that patients with severe renal impairment be closely monitored during treatment with ViraferonPeg (see section 4.2)
Croatian: Zbog izražene interindividualne varijabilnosti u farmakokinetici interferona preporučuje se tijekom liječenja lijekom ViraferonPeg pomno nadzirati bolesnike s teškim oštećenjem funkcije bubrega (vidjeti dio 4.2).
English: The reconstituted solution should be clear and colourless.
Croatian: Rekonstituirana otopina mora biti bistra i bezbojna.
English: ViraferonPeg monotherapy - Adults
Croatian: ViraferonPeg u monoterapiji - odrasli
English: Congestive heart failure, cardiomyopathy, arrhythmia, pericarditis
Croatian: kongestivno zatajenje srca, kardiomiopatija, aritmija, perikarditis
English: • Genotype 4:
Croatian: • Genotip 4:
English: Collect the necessary items before you begin: - a vial of ViraferonPeg powder for injection; - an ampoule of water for injections solvent to prepare ViraferonPeg injection; - a 1 ml syringe; - a long needle (for example 0.8  40 mm [21 gauge 1.5 inch]) to be used to add water for injections to the ViraferonPeg powder vial; - a short needle (for example 0.3  13 mm [30 gauge 0.5 inch]) for the subcutaneous injection; - a cleansing swab.
Croatian: Prije nego što počnete, prikupite sve što Vam je potrebno: - bočicu ViraferonPeg praška za injekciju; - ampulu s vodom za injekcije - otapalom s kojim ćete pripremiti ViraferonPeg injekciju; - štrcaljku od 1 ml; - dugačku iglu (primjerice 0,8 x 40 mm [21 gauge]) kojom ćete dodati vodu za injekcije u bočicu s ViraferonPeg praškom; - kratku iglu za potkožnu injekciju (primjerice 0,3 x 13 mm [30 gauge]); - tupfer za čišćenje.
English: For HCV/HIV co-infected patients receiving ViraferonPeg in combination with ribavirin, other undesirable effects (that were not reported in mono-infected patients) which have been reported in the larger studies with a frequency > 5 % were: oral candidiasis (14 %), lipodystrophy acquired (13 %), CD4 lymphocytes decreased (8 %), appetite decreased (8 %), gamma-glutamyltransferase increased (9 %), back pain (5 %), blood amylase increased (6 %), blood lactic acid increased (5 %), cytolytic hepatitis (6 %), lipase increased (6 %) and pain in limb (6 %).
Croatian: U bolesnika s istodobnom infekcijom HCV-om i HIV-om koji su primali ViraferonPeg u kombinaciji s ribavirinom ostali neželjeni učinci (koji nisu prijavljeni u bolesnika inficiranih samo jednim virusom) prijavljeni u većim kliničkim ispitivanjima s učestalošću od > 5% uključuju: oralnu kandidijazu (14%), stečenu lipodistrofiju (13%), smanjen broj CD4 limfocita (8%), oslabljen tek (8%), povišene vrijednosti gama-glutamiltransferaze (9%), bol u leđima (5%), povišene vrijednosti amilaze u krvi (6%), povišene vrijednosti mliječne kiseline u krvi (5%), citolitički hepatitis (6%), povišene vrijednosti lipaze (6%) i bol u udovima (6%).
English: - The use of ViraferonPeg in children and adolescents with existence of or history of severe psychiatric conditions is contraindicated (see section 4.3).
Croatian: - Kontraindicirana je primjena lijeka ViraferonPeg u djece i adolescenata s postojećim teškim psihijatrijskim bolestima ili anamnezom takvih bolesti (vidjeti dio 4.3).
English: If you forget to take ViraferonPeg
Croatian: Ako ste zaboravili primijeniti ViraferonPeg
English: Tritherapy (ViraferonPeg with ribavirin and boceprevir): applies to adult patients with genotype 1 CHC.
Croatian: Trojna terapija (ViraferonPeg s ribavirinom i boceprevirom): vrijedi za odrasle bolesnike s kroničnim hepatitisom C genotipa 1.
English: Table 10 Virologic response at end of treatment, Sustained Virologic Response and relapse by HCV Genotype and viral load* ViraferonPeg 1.5 g/kg once weekly plus Ribavirin 800-1,400 mg/day End of treatment response
Croatian: Tablica 10 Virološki odgovor na kraju liječenja, trajan virološki odgovor i relaps prema HCV genotipu i virusnom opterećenju* ViraferonPeg 1,5 μg/kg jedanput na tjedan + ribavirin 800-1400 mg/dan Odgovor na kraju liječenja
English: Metabolism of thioridazine is suppressed by inhibitory action of the product (ViraferonPeg) on CYP2D6.
Croatian: Metabolizam tioridazina potisnut je zbog inhibitornog djelovanja ovog lijeka (ViraferonPeg) na CYP2D6.
English: Sustained response was assessed by the response rate six months after the cessation of treatment.
Croatian: Trajan terapijski odgovor određivao se na temelju stope odgovora na terapiju šest mjeseci nakon završetka liječenja.
English: Hypotension, pallor
Croatian: hipotenzija, bljedoća
English: • Support the pre-filled pen in upright position and push the needle straight down firmly (see Figure 6).
Croatian: • Držite napunjenu brizgalicu uspravno i iglu čvrsto pritisnite prema dolje (vidjeti Sliku 6).
English: Other CNS effects including aggressive behaviour (sometimes directed against others such as homicidal ideation), bipolar disorders, mania, confusion and alterations of mental status have been observed with alpha interferons.
Croatian: Kod liječenja alfa interferonima opaženi su drugi učinci na SŽS, uključujući agresivno ponašanje (ponekad usmjereno protiv drugih, poput homicidalnih ideja), bipolarne poremećaje, maniju, konfuziju i promjene mentalnog statusa.
English: Also see SmPCs for ribavirin and boceprevir if ViraferonPeg is to be administered in combination therapy in patients with chronic hepatitis C.
Croatian: Pročitajte i Sažetak opisa svojstava lijeka za ribavirin i boceprevir ako će se ViraferonPeg primjenjivati u kombiniranom liječenju u bolesnika s kroničnim hepatitisom C.
English: Caffeine (CYP1A2 substrate)
Croatian: Kofein (supstrat CYP1A2)
English: The white powder is contained in a 2 ml glass vial and the clear and colourless solvent is presented in a 2 ml glass ampoule.
Croatian: Bijeli prašak nalazi se u staklenoj bočici volumena 2 ml, a bistro i bezbojno otapalo nalazi se u staklenoj ampuli volumena 2 ml.
English: Store in a refrigerator (2C - 8C).
Croatian: Čuvati u hladnjaku (2°C-8°C).
English: Infrequently, adult patients treated for chronic hepatitis C with interferon alpha have developed thyroid abnormalities, either hypothyroidism or hyperthyroidism.
Croatian: U rijetkim su slučajevima odrasli bolesnici liječeni interferonom alfa zbog kroničnog hepatitisa C razvili poremećaj rada štitnjače, bilo hipotireozu ili hipertireozu.
English: You can save the swab to clean the skin area where you will inject the dose.
Croatian: Možete sačuvati tupfer da očistite kožu na mjestu injekcije.
English: Haematological abnormalities were more frequently reported in patients receiving ViraferonPeg in combination with ribavirin when compared to patients receiving interferon alfa-2b in combination with ribavirin.
Croatian: Hematološki poremećaji prijavljeni su češće u bolesnika koji su primali ViraferonPeg u kombinaciji s ribavirinom u odnosu na bolesnike koji su primali interferon alfa-2b u kombinaciji s ribavirinom.
English: This medicine is a powder and solvent (liquid) for solution for injection.
Croatian: Ovaj lijek je prašak i otapalo (tekućina) za otopinu za injekciju.
English: The pharmacokinetics of ViraferonPeg have not been evaluated in patients with severe hepatic dysfunction.
Croatian: Farmakokinetika lijeka ViraferonPeg nije se ispitivala u bolesnika s teškim oštećenjem jetrene funkcije.
English: 9/l l
Croatian: 9/l i
English: Cerebrovascular haemorrhage, cerebrovascular ischaemia, encephalopathy
Croatian: cerebrovaskularno krvarenje, cerebrovaskularna ishemija, encefalopatija
English: - Clean the rubber top of the vial with a cleansing swab.
Croatian: - Očistite gumeni vrh bočice tupferom za čišćenje.
English: Bacterial infection (including sepsis), fungal infection, influenza, upper respiratory tract infection, bronchitis, herpes simplex, sinusitis, otitis media, rhinitis
Croatian: bakterijska infekcija (uključujući sepsu), gljivična infekcija, gripa, infekcija gornjih dišnih puteva, bronhitis, herpes simplex, sinusitis, upala srednjeg uha, rinitis
English: Chronic Hepatitis C Subjects (N=24)
Croatian: Ispitanici s kroničnim hepatitisom C (N=24)
English: c: Patients with genotype 3 low viral load (< 600,000 IU/ml) were to receive 24 weeks of treatment while those with genotype 3 and high viral load (≥ 600,000 IU/ml) were to receive 48 weeks of treatment.
Croatian: c: Bolesnici s genotipom 3 i malim virusnim opterećenjem (< 600 000 IU/ml) liječeni su 24 tjedna, a bolesnici s genotipom 3 i velikim virusnim opterećenjem (≥ 600 000 IU/ml) 48 tjedana.
English: Therefore, the combination of ViraferonPeg with telbivudine is contraindicated (see section 4.3).
Croatian: Stoga je kombinacija lijeka ViraferonPeg s telbivudinom kontraindicirana (vidjeti dio 4.3).
English: a: 2 morning, 2 evening b: 2 morning, 3 evening c: 3 morning, 3 evening d: 3 morning, 4 evening * Refer to the SmPC of boceprevir for details about the dose of boceprevir to be administered in tritherapy.
Croatian: a: 2 ujutro, 2 navečer b: 2 ujutro, 3 navečer c: 3 ujutro, 3 navečer d: 3 ujutro, 4 navečer
English: Immuno-suppressive therapy
Croatian: Imunosupresivna terapija
English: Data are not available for the use of ViraferonPeg in patients with creatinine clearance < 15 ml/minute (see section 5.2).
Croatian: Nema podataka o primjeni lijeka ViraferonPeg u bolesnika s klirensom kreatinina < 15 ml/min (vidjeti dio 5.2).
English: Ribavirin causes serious birth defects when administered during pregnancy, therefore ribavirin therapy is contraindicated in women who are pregnant.
Croatian: Kad se primjenjuje u trudnoći, ribavirin uzrokuje ozbiljne prirođene anomalije te je stoga liječenje ribavirinom u trudnica kontraindicirano.
English: Gently place the needle tip against the glass wall of the vial without touching the cleaned top of the vial with your hands.
Croatian: Nježno prislonite vrh igle na staklenu stijenku bočice i nemojte rukama dodirivati očišćeni vrh bočice.
English: The cartridge is sealed at one end with a polypropylene cap containing a bromobutyl rubber liner and at the other end by a bromobutyl rubber plunger.
Croatian: Uložak je na jednom kraju zatvoren polipropilenskom kapicom s graničnikom od brombutilne gume, a na drugom klipom od brombutilne gume.
English: After the needle is inserted, remove the hand used to pinch the skin and use it to hold the syringe barrel.
Croatian: Nakon što ubodete iglu, maknite ruku kojom ste držali nabor kože i njome držite tijelo štrcaljke.
English: Genotype 1  600,000 IU/ml
Croatian: Genotip 1  600 000 IU/ml
English: In addition, 303 patients received interferon alfa-2b (3 million International Units [MIU] three times a week) as a comparator.
Croatian: Osim toga, 303 bolesnika su primala interferon alfa-2b (3 milijuna internacionalnih jedinica [mil.
English: How to self-inject ViraferonPeg?
Croatian: Kako da si sami date injekciju lijeka ViraferonPeg?
English: Disposal of the injection materials
Croatian: Zbrinjavanje materijala za injekciju
English: There are no apparent age-related effects on the pharmacokinetics of ViraferonPeg.
Croatian: Nema očitih dobno uvjetovanih učinaka na farmakokinetiku lijeka ViraferonPeg.
English: Other baseline factors in co-infected patients that may be associated with a higher risk of hepatic decompensation include treatment with didanosine and elevated bilirubin serum concentration.
Croatian: Na početku liječenja bolesnika s istodobnom infekcijom ostali čimbenici koji mogu biti povezani s povećanim rizikom od dekompenzacije jetre uključuju liječenje didanozinom i povećanu koncentraciju bilirubina u serumu.
English: Interferon neutralising factors
Croatian: Čimbenici koji neutraliziraju interferon
English: Dispose of the used pre-filled pen safely in a closed container.
Croatian: Napunjenu brizgalicu zbrinite na siguran način u zatvorenom spremniku.
English: In children and adolescent patients receiving body surface area-adjusted dosing of ViraferonPeg at 60 g/m2/week, the log transformed ratio estimate of exposure during the dosing interval is predicted to be 58 % (90 % CI: 141-177 %) higher than observed in adults receiving 1.5 g/kg/week.
Croatian: Predviđa se da će u djece i adolescenata koji primaju dozu lijeka ViraferonPeg od 60 µg/m2 na tjedan, prilagođenu prema tjelesnoj površini, logaritamski transformiran procijenjeni omjer izloženosti lijeku u intervalu doziranja biti 58% (90% CI: 141-177%) veći od onog zabilježenog u odraslih bolesnika koji su primali dozu od 1,5 µg/kg na tjedan.
English: Co-infected patients receiving both antiretroviral (ARV) and anti-hepatitis treatment should be closely monitored, assessing their Child-Pugh score during treatment.
Croatian: Bolesnike s istodobnom infekcijom koji primaju i antiretrovirusne lijekove i terapiju za liječenje hepatitisa treba pomno nadzirati te im tijekom liječenja treba određivati Child-Pugh rezultat.
English: Twenty-four percent of subjects (11/46) treated for 24 weeks and 40 % of subjects (19/48) treated for 48 weeks had a > 15 percentile height-for-age decrease from pre-treatment to the end of the 5 year long-term follow-up compared to pre-treatment baseline percentile.
Croatian: U 24% djece (11/46) liječene 24 tjedna i 40% djece (19/48) liječene 48 tjedana zabilježen je pad za > 15 percentila na percentilnoj krivulji rasta za dob od razdoblja prije početka liječenja do kraja 5-godišnjeg dugotrajnog praćenja u usporedbi s percentilima prije početka liječenja.
English: Clinical efficacy and safety - paediatric population Children and adolescents 3 to 17 years of age with compensated chronic hepatitis C and detectable HCV-RNA were enrolled in a multicentre trial and treated with ribavirin 15 mg/kg per day plus ViraferonPeg 60 g/m2 once weekly for 24 or 48 weeks, based on HCV genotype and baseline viral load.
Croatian: Klinička djelotvornost i sigurnost - pedijatrijska populacija Djeca i adolescenti u dobi od 3 do 17 godina s kompenziranim kroničnim hepatitisom C i mjerljivom HCV-RNK uključeni su u multicentrično ispitivanje i liječeni ribavirinom u dozi od 15 mg/kg na dan i lijekom ViraferonPeg u dozi od 60 μg/m2 jedanput na tjedan tijekom 24 ili 48 tjedana, ovisno o genotipu HCV-a i početnom virusnom opterećenju.
English: Hypocalcemia, hyperuricemia, dehydration, increased appetite
Croatian: hipokalcijemija, hiperuricemija, dehidracija, pojačan tek
English: Teeth and mouth problems have been reported in patients receiving this medicine in combination with ribavirin.
Croatian: Tegobe sa zubima i usnom šupljinom prijavljene su u bolesnika koji su primali ovaj lijek u kombinaciji s ribavirinom.
English: Homicidal ideation, mania Nervous system disorders Very common:
Croatian: homicidne misli, manija Poremećaji živčanog sustava Vrlo često:
English: - The active substance is peginterferon alfa-2b.
Croatian: - Djelatna tvar je peginterferon alfa-2b.
English: - Tap the top of the ampoule of solvent gently to make sure that all the liquid is at the bottom of the ampoule.
Croatian: - Nježno kucnite po ampuli s otapalom kako bi sva tekućina pala na dno ampule.
English: When used in combination with ribavirin, ViraferonPeg did not cause any effects not previously seen with either active substance alone.
Croatian: Kada se primjenjivao u kombinaciji s ribavirinom, ViraferonPeg nije prouzročio učinke koji već nisu bili opaženi prilikom zasebne primjene tih dvaju lijekova.
English: Pulmonary changes
Croatian: Promjene na plućima
English: Using a sterilised injection syringe and injection needle, 0.7 ml of water for injections is injected into the vial of ViraferonPeg.
Croatian: Uz pomoć sterilizirane štrcaljke i igle za injekciju, 0,7 ml vode za injekcije ubrizga se u bočicu s lijekom ViraferonPeg.
English: P 1.5/R ViraferonPeg (1.5 micrograms/kg) + ribavirin (800 mg) P 0.5/R ViraferonPeg (1.5 to 0.5 microgram/kg) + ribavirin (1,000/1,200 mg) I/R
Croatian: P 1,5/R ViraferonPeg (1,5 mikrograma/kg) + ribavirin (800 mg) P 0,5/R ViraferonPeg (1,5 do 0,5 mikrograma/kg) + ribavirin (1000/1200 mg) I/R
English: You or your partner must use an effective birth control during the time you are taking ribavirin and for 7 months after stopping treatment.
Croatian: Vi ili Vaša partnerica morate koristiti pouzdanu kontracepciju za vrijeme Vašeg liječenja ribavirinom i još 7 mjeseci nakon prestanka liječenja.
English: Vomiting *, nausea, abdominal pain, diarrhoea, dry mouth*
Croatian: povraćanje*, mučnina, bol u abdomenu, proljev, suha usta*
English: Acute hypersensitivity reactions including angioedema, anaphylaxis and anaphylactic reactions including anaphylactic shock, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, systemic lupus erythematosus
Croatian: reakcije akutne preosjetljivosti uključujući angioedem, anafilaksija i anafilaktičke reakcije uključujući anafilaktički šok, idiopatska trombocitopenična purpura, trombocitna trombocitopenična purpura, sistemski lupus eritematosus
English: Severe CNS effects, particularly depression, suicidal ideation and attempted suicide have been observed in some patients during ViraferonPeg therapy, and even after treatment discontinuation mainly during the 6-month follow-up period.
Croatian: Psihijatrijski poremećaji i bolesti središnjeg živčanog sustava (SŽS) U nekih su bolesnika primijećeni teški štetni učinci na SŽS, osobito depresija, suicidalne misli i pokušaj samoubojstva, za vrijeme liječenja lijekom ViraferonPeg te čak i nakon obustave liječenja, uglavnom tijekom šestomjesečnog razdoblja praćenja.