FrancophonIA/ELRC3.0 huggingface dataset:
English: Reduction of daily dose by 10 mg/kg/day (dispersible tablet formulation), if following renal parameters are observed at two consecutive visits and cannot be attributed to other causes
Croatian: Smanjenje dnevne doze za 10 mg/kg/dan (formulacija tablete za oralnu suspenziju), ako su sljedeći bubrežni parametri uočeni tijekom dva uzastopna posjeta te se ne mogu pripisati drugim uzrocima
English: Particular attention should therefore be paid to monitoring of serum creatinine in patients who are concomitantly receiving medicinal products that depress renal function, and in patients who are receiving high doses of deferasirox and/or low rates of transfusion (<7 ml/kg/month of packed red blood cells or <2 units/month for an adult).
Croatian: Stoga treba obratiti posebnu pozornost na praćenje serumskog kreatinina u bolesnika koji istodobno primaju lijekove koji smanjuju bubrežnu funkciju te u bolesnika koji primaju visoke doze deferasiroksa i/ili manju količinu transfuzija (<7 ml/kg/mjesec koncentrata eritrocita ili <2 jedinice/mjesec u odraslih).
English: You may experience effects such as abdominal pain, diarrhoea, nausea and vomiting and kidney or liver problems that can be serious.
Croatian: Mogli biste razviti nuspojave poput boli u trbuhu, proljeva, mučnine i povraćanja te tegobe s bubrezima ili jetrom koje mogu biti ozbiljne.
English: Not all pack sizes or strengths may be available in your country.
Croatian: Na tržištu se ne moraju nalaziti sve veličine pakiranja ili jačine lijeka.
English: Deferasirox is an orally active chelator that is highly selective for iron (III).
Croatian: Deferasiroks je visoko selektivan kelator za željezo (III), djelotvoran pri peroralnoj primjeni.
English: Post-marketing cases of hepatic failure, some of which were fatal, have been reported.
Croatian: Nakon stavljanja lijeka u promet prijavljeni su slučajevi zatajenja jetre, od kojih su neki bili fatalni.
English: As a consequence, treatment with EXJADE is not recommended in these patients.
Croatian: Kao posljedica toga, u tih se bolesnika ne preporučuje liječenje lijekom EXJADE.
English: The tablets are white to slightly yellow, round and flat.
Croatian: Tablete su bijele do žućkaste, okrugle i plosnate.
English: • Disturbance in kidney function tests.
Croatian: • Poremećaj testova funkcije bubrega.
English: However, in patients with liver iron concentration <7 mg Fe/g dw treated with deferasirox dispersible tablets (5 and 10 mg/kg) or deferoxamine (20 to 35 mg/kg), non-inferiority was not established due to imbalance in the dosing of the two chelators.
Croatian: Međutim, u bolesnika s koncentracijom željeza u jetri <7 mg Fe/g suhe težine liječenih deferasiroks tabletama za oralnu suspenziju (5 i 10 mg/kg) ili deferoksaminom (20 do 35 mg/kg) neinferiornost nije potvrđena zbog neravnoteže u doziranju dvaju kelatora.
English: Unit packs containing 30 sachets.
Croatian: Jedinično pakiranje sadrži 30 vrećica.
English: In a retrospective meta-analysis of 2,102 adult and paediatric beta-thalassaemia patients with transfusional iron overload treated with deferasirox dispersible tablets in two randomised and four open label studies of up to five years' duration, a mean creatinine clearance decrease of 13.2% in adult patients (95% CI: -14.4% to -12.1%; n=935) and 9.9% (95% CI: -11.1% to -8.6%; n=1,142) in paediatric patients was observed during the first year of treatment.
Croatian: Klirens kreatinina pri preopterećenju željezom izazvanom transfuzijama U retrospektivnoj meta-analizi 2102 odrasla i pedijatrijska bolesnika s beta-talasemijom s preopterećenjem željezom izazvanim transfuzijama koji su liječeni deferasiroks tabletama za oralnu suspenziju u dva randomizirana i četiri otvorena ispitivanja u trajanju do pet godina, zapažena je srednja vrijednost smanjenja klirensa kreatinina od 13,2% u odraslih bolesnika (95% CI: -14,4% do -12,1%; n=935) i 9,9% (95% CI: -11,1% do -8,6%; n=1142) u pedijatrijskih bolesnika tijekom prve godine liječenja.
English: Multipack: 294 (3 packs of 98) dispersible tablets.
Croatian: Višestruko pakiranje: 294 (3 pakiranja po 98) tableta za oralnu suspenziju.
English: Film-coated tablets/granules
Croatian: Filmom obložene tablete/granule
English: 252 dispersible tablets
Croatian: 252 tablete za oralnu suspenziju
English: Although deferasirox has a lower affinity for aluminium than for iron, it is not recommended to take deferasirox granules with aluminium-containing antacid preparations.
Croatian: Premda je afinitet deferasiroksa za aluminij niži nego za željezo, ne preporučuje se uzimati deferasiroks granule istodobno s antacidima koji sadrže aluminij.
English: Caution should be taken during chelation therapy to minimise the risk of overchelation in all patients (see section 4.4).
Croatian: Nužan je oprez tijekom kelacijske terapije kako bi se rizik od prekomjerne kelacije sveo na najmanju moguću mjeru u svih bolesnika (vidjeti dio 4.4).
English: <7 ml/kg/month of PRBC (approx. <2 units/month for an adult)
Croatian: <7 ml/kg/mjesec KE-a (otprilike <2 jedinice/mjesec za odraslu osobu)
English: • If you experience difficulty thinking, remembering information, or solving problems, being less alert or aware or feeling very sleepy with low energy (signs of a high level of ammonia in your blood, which may be associated with liver or renal problems and lead to a change in your brain function),
Croatian: smanjenu pozornost ili svijest ili osjećaj izrazite pospanosti uz nisku razinu energiju (znakovi visoke razine amonijaka u Vašoj krvi, što može biti povezano s jetrenim ili bubrežnim tegobama te dovesti do promjene moždane funkcije),
English: Unit packs containing 28, 84 or 252 dispersible tablets and multipacks containing 294 (3 packs of 98) dispersible tablets.
Croatian: Jedinično pakiranje sadrži 28, 84 ili 252 tablete za oralnu suspenziju, a višestruko pakiranje sadrži 294 (3 pakiranja od 98) tablete za oralnu suspenziju.
English: Chelation therapy should only be initiated when there is evidence of iron overload (liver iron concentration [LIC] ≥5 mg Fe/g dry weight [dw] or serum ferritin consistently >800 µg/l).
Croatian: Kelacijska se terapija započinje kad postoji dokaz preopterećenja željezom (koncentracija željeza u jetri [LIC, engl. liver iron concentration] ≥5 mg Fe/g težine suhog tkiva jetre ili serumskog feritina dosljedno >800 µg/l).
English: • Swelling of arms or legs
Croatian: • Oticanje ruku ili nogu
English: Daily treatment with the deferasirox dispersible tablet formulation at doses of 20 and 30 mg/kg for one year in frequently transfused adult and paediatric patients with beta-thalassaemia led to reductions in indicators of total body iron; liver iron concentration was reduced by about -0.4 and -8.9 mg Fe/g liver (biopsy dry weight (dw)) on average, respectively, and serum ferritin was reduced by about -36 and -926 µg/l on average, respectively.
Croatian: Dnevno liječenje deferasiroksom u formulaciji tablete za oralnu suspenziju u dozama od 20 i 30 mg/kg tijekom jedne godine u odraslih i pedijatrijskih bolesnika s beta-talasemijom koji su često primali transfuzije dovelo je do smanjenja pokazatelja ukupnog željeza u tijelu; koncentracija željeza u jetri smanjila se prosječno za -0,4, odnosno za -8,9 mg Fe/g jetre (suha težina (st) biopsijskog materijala), a serumski feritin smanjio se u prosjeku za -36, odnosno za -926 µg/l.
English: Monthly monitoring of serum ferritin is recommended in order to assess the patient's response to therapy and to avoid overchelation (see section 4.2).
Croatian: Preporučuje se praćenje serumskog feritina jednom mjesečno zbog procjene bolesnikova odgovora na terapiju te radi izbjegavanja prekomjerne kelacije (vidjeti dio 4.2).
English: Renal tubulopathy has been mainly reported in children and adolescents with beta-thalassaemia treated with EXJADE.
Croatian: Bubrežna tubulopatija je uglavnom prijavljivana u djece i adolescenata s beta-talasemijom liječenih EXJADE-om.
English: EXJADE is also indicated for the treatment of chronic iron overload due to blood transfusions when deferoxamine therapy is contraindicated or inadequate in the following patient groups: - in paediatric patients with beta thalassaemia major with iron overload due to frequent blood transfusions (7 ml/kg/month of packed red blood cells) aged 2 to 5 years, - in adult and paediatric patients with beta thalassaemia major with iron overload due to infrequent blood transfusions (<7 ml/kg/month of packed red blood cells) aged 2 years and older, - in adult and paediatric patients with other anaemias aged 2 years and older.
Croatian: EXJADE je također indiciran za liječenje kroničnog preopterećenja željezom zbog transfuzija krvi kada je terapija deferoksaminom kontraindicirana ili neodgovarajuća u sljedećim skupinama bolesnika: - pedijatrijski bolesnici s beta-talasemijom major i preopterećenjem željezom zbog učestalih transfuzija krvi (≥7 ml/kg/mjesec koncentrata eritrocita) u dobi od 2 do 5 godina, - odrasli i pedijatrijski bolesnici s beta-talasemijom major i preopterećenjem željezom zbog neučestalih transfuzija krvi (<7 ml/kg/mjesec koncentrata eritrocita) u dobi od 2 godine i stariji, - odrasli i pedijatrijski bolesnici s drugim vrstama anemija u dobi od 2 godine i stariji.
English: 300 (10 packs of 30) film-coated tablets
Croatian: 300 (10 pakiranja od 30) filmom obloženih tableta
English: After adjustment of the strength, the film-coated tablet formulation (360 mg strength) was equivalent to EXJADE dispersible tablets (500 mg strength) with respect to the mean area under the plasma concentration time curve (AUC) under fasting conditions.
Croatian: Nakon prilagodbe jačine, formulacija filmom obloženih tableta (jačina 360 mg) bila je ekvivalentna EXJADE formulaciji tablete za oralnu suspenziju (jačina 500 mg) s obzirom na srednju površinu ispod krivulje koncentracije u plazmi i vremena (AUC) kada se uzima natašte.
English: For patients who are unable to swallow whole tablets, EXJADE film-coated tablets may be crushed and taken by sprinkling the full dose onto soft food such as yogurt or apple sauce (pureed apple).
Croatian: Za bolesnike koji ne mogu progutati cijele tablete, EXJADE filmom obložene tablete mogu se zdrobiti i uzeti posipanjem cijele doze na meku hranu kao što je jogurt ili jabučna kaša (pire od jabuke).
English: What EXJADE is used for
Croatian: Za što se EXJADE koristi
English: 28 dispersible tablets 84 dispersible tablets 252 dispersible tablets
Croatian: 28 tableta za oralnu suspenziju 84 tablete za oralnu suspenziju 252 tablete za oralnu suspenziju
English: - if you experience difficulty thinking, remembering information, or solving problems, being less alert or aware or feeling very sleepy with low energy (signs of a high level of ammonia in your blood, which may be associated with liver or renal problems, see also section 4 “Possible side effects”).
Croatian: smanjenu pozornost ili svijest ili osjećaj izrazite pospanosti uz nisku razinu energije (znakovi visoke razine amonijaka u Vašoj krvi, što može biti povezano s jetrenim ili bubrežnim tegobama, vidjeti također dio 4. „Moguće nuspojave”).
English: The other ingredients are lactose monohydrate, crospovidone type A, povidone, sodium laurilsulfate, microcrystalline cellulose, colloidal anhydrous silica and magnesium stearate.
Croatian: Drugi sastojci su laktoza hidrat, krospovidon tip A, povidon, natrijev laurilsulfat, mikrokristalična celuloza, koloidni bezvodni silicijev dioksid i magnezijev stearat.
English: Treatment with EXJADE should be initiated and maintained by physicians experienced in the treatment of chronic iron overload.
Croatian: Liječenje lijekom EXJADE mora započeti i dalje pratiti liječnik iskusan u liječenju kroničnog preopterećenja željezom.
English: A food-effect study involving administration of the film-coated tablets to healthy volunteers under fasting conditions and with a low-fat (fat content <10% of calories) or high-fat (fat content >50% of calories) meal indicated that the AUC and Cmax were slightly decreased after a low-fat meal (by 11% and 16%, respectively).
Croatian: Ispitivanje učinka hrane koje je uključivalo primjenu filmom obloženih tableta u zdravih dobrovoljaca natašte te uz nemasni (sadržaj masti <10% kalorija) ili punomasni (sadržaj masti >50% kalorija) obrok ukazalo je na to da su AUC i Cmax bili blago povišeni nakon nemasnog obroka (za 11% odnosno 16%).
English: Dose adjustments may be made in steps of 5 to 10 mg/kg and are to be tailored to the individual patient's response and therapeutic goals (maintenance or reduction of iron burden).
Croatian: Prilagodbe doze, ako je potrebno, se mogu provoditi u koracima po 5 do 10 mg/kg vodeći računa o individualnom odgovoru bolesnika i terapijskim ciljevima (održavanje ili smanjenje opterećenja željezom).
English: Skin rashes may appear during EXJADE treatment.
Croatian: Tijekom liječenja lijekom EXJADE moguća je pojava kožnih osipa.
English: After adjustment of the strength, the granules formulation (4 x 90 mg strength) was equivalent to EXJADE dispersible tablets (500 mg strength) with respect to the mean area under the plasma concentration time curve (AUC) under fasting conditions.
Croatian: Nakon prilagodbe jačine, formulacija granula (jačina 4 x 90 mg) bila je ekvivalentna EXJADE formulaciji tablete za oralnu suspenziju (jačina 500 mg) s obzirom na srednju površinu ispod krivulje koncentracije u plazmi i vremena (AUC) kada se uzima natašte.
English: For deferasirox granules, a dose ratio of 3:1 can be considered (i.e. a dose of deferasirox granules that is numerically one third of the deferoxamine dose).
Croatian: Za deferasiroks granule može se razmotriti omjer doza 3:1 (tj. doza deferasiroks granula koja iznosi trećinu brojčane vrijednosti doze deferoksamina).
English: • If you experience frequent heartburn,
Croatian: • Ako imate česte žgaravice,
English: Monitoring your EXJADE treatment
Croatian: Praćenje liječenja lijekom EXJADE
English: Dose adjustments may be made in steps of 3.5 to 7 mg/kg and are to be tailored to the individual patient's response and therapeutic goals (maintenance or reduction of iron burden).
Croatian: Prilagodbe doze, ako je potrebno, se mogu provoditi u koracima po 3,5 do 7 mg/kg vodeći računa o individualnom odgovoru bolesnika i terapijskim ciljevima (održavanje ili smanjenje opterećenja željezom).
English: EXJADE 125 mg, 250 mg and 500 mg dispersible tablets are available in unit packs containing 28, 84 or 252 dispersible tablets.
Croatian: EXJADE 125 mg, 250 mg i 500 mg tablete za oralnu suspenziju su dostupne u jediničnim pakiranjima koja sadrže 28, 84 ili 252 tablete za oralnu suspenziju.
English: - if you notice a marked decrease in your urine output (sign of kidney problem).
Croatian: - ako primijetite izrazito smanjenje izlučivanja mokraće (znak bubrežnog problema).
English: • Do not use this medicine after the expiry date which is stated on the blister and the carton after EXP.
Croatian: • Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na blisteru i kutiji iza oznake „Rok valjanosti“/„EXP“.
English: Doses above 40 mg/kg are not recommended because there is only limited experience with doses above this level.
Croatian: Ne preporučuje se primjena doza iznad 40 mg/kg zbog ograničenog iskustva s dozama iznad te razine.
English: Starting dose 7 mg/kg/day
Croatian: Početna doza 7 mg/kg/dan
English: The availability of long-term efficacy and safety data with EXJADE dispersible tablets used at doses above 30 mg/kg is currently limited (264 patients followed for an average of 1 year after dose escalation).
Croatian: Trenutačno se raspolaže tek ograničenim podacima o dugotrajnoj djelotvornosti i sigurnosti EXJADE tableta za oralnu suspenziju pri dozama iznad 30 mg/kg (264 bolesnika koji su bili praćeni prosječno 1 godinu nakon povećavanja doze).
English: In case of switching from film-coated tablets/granules to dispersible tablets, the dose of dispersible tablets should be 40% higher than the dose of film-coated tablets/granules, rounded to the nearest whole tablet.
Croatian: U slučaju prelaska s filmom obloženih tableta/granula na tablete za oralnu suspenziju, doza tableta za oralnu suspenziju treba biti 40% viša od doze filmom obloženih tableta/granula, zaokruženo na najbližu cijelu tabletu.
English: It is recommended that serum creatinine be assessed in duplicate before initiating therapy.
Croatian: Prije početka terapije preporučuje se određivanje serumskog kreatinina u duplikatu.
English: 98 dispersible tablets.
Croatian: 98 tableta za oralnu suspenziju.
English: If you are switching from the dispersible tablets to these granules, you will need an adjustment of the dose.
Croatian: Ako prelazite s tableta za oralnu suspenziju na ove granule, bit će Vam potrebna prilagodba doze.
English: Stevens-Johnson syndrome1, hypersensitivity vasculitis1, urticaria1, erythema multiforme
Croatian: Stevens-Johnsonov sindrom 1, hipersenzitivni vaskulitis
English: Doses above 20 mg/kg are not recommended because there is no experience with doses above this level in patients with non-transfusion-dependent thalassaemia syndromes.
Croatian: Doze iznad 20 mg/kg ne preporučuju se zbog toga što nema iskustva s dozama iznad te razine u bolesnika sa sindromima talasemije neovisnim o transfuziji.
English: In addition, in patients with liver iron concentration ≥7 mg Fe/g dw with various rare anaemias or sickle cell disease, deferasirox dispersible tablets up to 20 and 30 mg/kg produced a decrease in liver iron concentration and serum ferritin comparable to that obtained in patients with beta-thalassaemia.
Croatian: Osim toga, u bolesnika s različitim rijetkim anemijama ili s bolešću srpastih stanica koji su imali koncentraciju željeza u jetri ≥7 mg Fe/g suhe težine, primjenom deferasiroks tableta za oralnu suspenziju u dozama do 20 i 30 mg/kg postignuto je sniženje koncentracije željeza u jetri i serumskog feritina usporedivo s onim postignutim u bolesnika s beta-talasemijom.
English: • Adults and Paediatrics: remain >33% above baseline or creatinine clearance <LLN (90 ml/min)
Croatian: • odrasli i pedijatrijski bolesnici: ostaje >33% iznad početne vrijednosti ili klirens kreatinina <DGN (90 ml/min)
English: Half of deferoxamine dose
Croatian: Polovica doze deferoksamina
English: When to take EXJADE
Croatian: Kada uzimati EXJADE
English: The most frequent reactions reported during chronic treatment with deferasirox dispersible tablets in adult and paediatric patients include gastrointestinal disturbances (mainly nausea, vomiting, diarrhoea or abdominal pain) and skin rash.
Croatian: Najčešće prijavljene reakcije tijekom kroničnog liječenja deferasiroks tabletama za oralnu suspenziju u odraslih i u pedijatrijskih bolesnika uključuju gastrointestinalne tegobe (uglavnom mučnina, povraćanje, proljev ili bol u trbuhu) i kožni osip.
English: EXJADE is also indicated for the treatment of chronic iron overload requiring chelation therapy when deferoxamine therapy is contraindicated or inadequate in patients with non-transfusion-dependent thalassaemia syndromes aged 10 years and older.
Croatian: EXJADE je također indiciran za liječenje kroničnog preopterećenja željezom koje zahtijeva terapiju kelatorima željeza kad je terapija deferoksaminom kontraindicirana ili neodgovarajuća za bolesnike u dobi od 10 godina i starije sa sindromima talasemije neovisnim o transfuziji.
English: Creatinine clearance and/or plasma cystatin C
Croatian: Klirens kreatinina i/ili cistatin C u plazmi Prije terapije.
English: No inhibition of deferasirox metabolism by hydroxyurea was observed in vitro.
Croatian: In vitro nije opaženo da bi hidroksiureja inhibirala metabolizam deferasiroksa.
English: EXJADE is indicated for the treatment of chronic iron overload due to frequent blood transfusions (7 ml/kg/month of packed red blood cells) in patients with beta thalassaemia major aged 6 years and older.
Croatian: EXJADE je indiciran za liječenje kroničnog preopterećenja željezom zbog čestih transfuzija krvi (≥7 ml/kg/mjesec koncentrata eritrocita) u bolesnika s beta-talasemijom major u dobi od 6 godina i starijih.
English: EXJADE is supplied as dispersible tablets.
Croatian: EXJADE se isporučuje u obliku tableta za oralnu suspenziju.
English: • EXJADE 360 mg film-coated tablets are dark blue and stamped “360” on one side and “NVR”
Croatian: • EXJADE 360 mg filmom obložene tablete su tamno plave i na jednoj strani imaju otisnutu oznaku „360“, a na drugoj strani „NVR“.
English: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), which could be lifethreatening or fatal, have been reported.
Croatian: Prijavljene su teške kožne nuspojave uključujući Stevens-Johnsonov sindrom (SJS), toksičnu epidermalnu nekrolizu (TEN) i reakciju na lijek s eozinofilijom i sistemskim simptomima (engl. drug reaction with eosinophilia and systemic symptoms, DRESS), koje mogu biti opasne po život ili smrtonosne.
English: In a healthy volunteer study, the concomitant administration of deferasirox as a CYP1A2 inhibitor (repeated dose of 30 mg/kg/day, dispersible tablet formulation) and the CYP1A2 substrate theophylline (single dose of 120 mg) resulted in an increase of theophylline AUC by 84% (90% CI: 73% to 95%).
Croatian: U ispitivanju na zdravim dobrovoljcima, istodobna primjena deferasiroksa kao inhibitora CYP1A2 (ponovljene doze od 30 mg/kg/dan, formulacija tablete za oralnu suspenziju) i supstrata CYP1A2 teofilina (jednokratna doza od 120 mg) rezultirala je povećanjem AUC teofilina za 84% (90% CI: 73% do 95%).
English: 84 dispersible tablets
Croatian: 84 tablete za oralnu suspenziju
English: EXJADE is also used to treat chronic iron overload when deferoxamine therapy is contraindicated or inadequate in patients with beta thalassaemia major with iron overload caused by infrequent blood transfusions, in patients with other types of anaemias, and in children aged 2 to 5 years.
Croatian: EXJADE se također koristi za liječenje kroničnog preopterećenja željezom kada je terapija deferoksaminom kontraindicirana ili neodgovarajuća u bolesnika s beta-talasemijom major s preopterećenjem željezom uzrokovanim rijetkim transfuzijama krvi, u bolesnika s ostalim vrstama anemija te u djece u dobi od 2 do 5 godina.
English: EXJADE granules should be taken by sprinkling the full dose onto soft food such as yogurt or apple sauce (pureed apple).
Croatian: EXJADE granule trebaju se uzeti posipanjem cijele doze na meku hranu kao što je jogurt ili jabučna kaša (pire od jabuke).
English: - if you experience frequent abdominal pain, particularly after eating or taking EXJADE.
Croatian: - ako imate česte bolove u trbuhu, posebno nakon jela ili uzimanja lijeka EXJADE. - ako imate česte žgaravice.
English: 5-10 mg/kg/day Up to 40 mg/kg/day Decrease 3.5 - 7 mg/kg/day 5-10 mg/kg/day
Croatian: 5-10 mg/kg/dan Do 40 mg/kg/dan Smanjenje 3,5 - 7 mg/kg/dan 5-10 mg/kg/dan
English: Deferasirox has been studied only in patients with baseline serum creatinine within the age-appropriate normal range.
Croatian: Deferasiroks je ispitivan samo u bolesnika čije su vrijednosti kreatinina u serumu na početku liječenja bile unutar granica normalnog raspona odgovarajućeg za dob.
English: 30 film-coated tablets 90 film-coated tablets
Croatian: Filmom obložene tablete 30 filmom obloženih tableta 90 filmom obloženih tableta
English: Cardiac function should be monitored in patients with severe iron overload during long-term treatment with EXJADE.
Croatian: U bolesnika s teškim preopterećenjem željezom potrebno je, pri dugotrajnom liječenju lijekom EXJADE, pratiti funkciju srca.
English: Bioavailability of deferasirox granules was 52% greater than that with dispersible tablets.
Croatian: Bioraspoloživost deferasiroks granula bila je 52% veća od bioraspoloživosti tableta za oralnu suspenziju.
English: Prior to therapy.
Croatian: Prije terapije.
English: >33% above pretreatment average and Decreases <LLN* (<90 ml/min)
Croatian: > 33% iznad prosjeka prije liječenja i smanjen <DGN-a* (<90 ml/min)