FrancophonIA/ELRC3.0 huggingface dataset:
English: Coadministration of these 2 active substances is generally not recommended.
Slovenian: Sočasna uporaba teh dveh učinkovin se načeloma ne priporoča.
English: All patients receiving coumarin anticoagulants must be carefully monitored.
Slovenian: Vse bolnike, ki prejemajo kumarinske antikoagulante, moramo skrbno spremljati.
English: Wait and take your next dose of Duzallo the next morning.
Slovenian: Počakajte in vzemite naslednji odmerek zdravila Duzallo naslednje jutro.
English: - you have or have had heart failure or other heart problems - your gout gets worse
Slovenian: - če imate ali ste kdaj imeli srčno popuščanje ali druge težave s srcem - če se vam protin poslabša
English: The large discrepancies in these values may be accounted for by variations in study design and/or creatinine clearance in the patients.
Slovenian: Velike razlike v vrednostih so lahko posledica razlik v načrtovanju študij in/ali kreatininskem očistku bolnikov.
English: Studies in animals with lesinurad do not indicate direct or indirect harmful effects.
Slovenian: Študije na živalih z lesinuradom ne kažejo neposrednih ali posrednih škodljivih učinkov.
English: Lesinurad has no or negligible influence on the ability to drive and use machines.
Slovenian: Lesinurad nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
English: Reported values for the elimination half-life range from 13.6 hours to 29 hours.
Slovenian: Razpolovni čas izločanja znaša od 13,6 do 29 ur.
English: Lesinurad is extensively bound to proteins in plasma (greater than 98%), mainly to albumin.
Slovenian: Lesinurad se v veliki meri veže na beljakovine v plazmi (več kot 98%), predvsem na albumin.
English: ATC code: M04AA51
Slovenian: Oznaka ATC: M04AA51
English: The highest risk for SJS and TEN, or other serious hypersensitivity reactions, is within the first weeks of treatment.
Slovenian: Največje tveganje za pojav SJS in TEN ali drugih resnih preobčutljivostnih reakcij je v prvih tednih zdravljenja.
English: Chronic kidney disease may increase the risk in these patients additionally.
Slovenian: Kronično obolenje ledvic lahko tveganje pri teh bolnikih še dodatno poveča.
English: Unchanged lesinurad in urine accounted for approximately 30% of the dose.
Slovenian: Nespremenjeni lesinurad v urinu je predstavljal približno 30% odmerka.
English: HLA-B*5801 allele
Slovenian: HLA-B*5801 alel
English: The safety and efficacy of Duzallo in children and adolescents under 18 years of age have not yet been established.
Slovenian: Varnost in učinkovitost zdravila Duzallo pri otrocih in mladostnikih, mlajših od 18 let, še nista bili dokazani.
English: If concomitant use is unavoidable, a dose reduction of didanosine may be required, and patients should be closely monitored.
Slovenian: Če je sočasna uporabi neizogibna, je morda potrebno znižati odmerek didanozina, in bolnike je treba skrbno spremljati.
English: Difference in proportion (95% C.I.)
Slovenian: Razlika v deležu (95% IZ)
English: Blood count monitoring should therefore be performed at regular intervals.
Slovenian: Krvno sliko je treba zato redno spremljati.
English: The use of genotyping has not been established in other patient populations.
Slovenian: Genotipizacija pri drugih populacijah bolnikov ni v uporabi.
English: The absolute bioavailability of lesinurad is approximately 100%.
Slovenian: Absolutna biološka uporabnost lesinurada je približno 100%.
English: These serum creatinine elevations generally resolved, most without treatment interruption.
Slovenian: Ta zvišanja kreatinina v serumu so na splošno izzvenela, večinoma brez prekinitve zdravljenja.
English: These effects usually occur in people with liver or kidney problems (agranulocytosis).
Slovenian: Taki učinki se običajno pojavijo pri ljudeh, ki imajo težave z jetri ali ledvicami (agranulocitoza).
English: The frequency of the HLA-B*5801 allele varies widely between ethnic populations: up to 20% in Han Chinese population, 8-15% in the Thai, about 12% in the Korean population and 1-2% in individuals of Japanese or European origin.
Slovenian: Pogostnost HLA-B*5801 alela se zelo razlikuje med etničnimi populacijami: do 20% pri Han Kitajcih, 8-15% pri Tajcih, približno 12% pri Korejcih in 1-2% pri Japoncih in Evropejcih.
English: Tell your doctor or pharmacist if you are taking any of the following:
Slovenian: Obvestite zdravnika ali farmacevta, če jemljete katero od naslednjih zdravil:
English: Do not drive or operate machinery if you are affected.
Slovenian: Ne vozite in ne upravljajte strojev, če se pri vas pojavijo ti znaki.
English: Frequency categories are defined according to the following conventions: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1000 to <1/100), rare (≥1/10000 to <1/1000) and very rare
Slovenian: Kategorije pogostnosti so opredeljene po naslednjem dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000) in zelo redki (< 1/10.000).
English: Skin reactions are the most common reactions and may occur at any time during treatment.
Slovenian: Kožne reakcije so najpogostejši neželeni učinki in se lahko pojavijo kadarkoli v času zdravljenja.
English: Renal clearance is 25.6 mL/min (coefficient of variation CV=56%).
Slovenian: Ledvični očistek je 25,6 ml/min (koeficient variacije KV = 56%).
English: Children and adolescents Duzallo is not recommended for use in children and adolescents below 18 years of age.
Slovenian: Otroci in mladostniki Zdravilo Duzallo ni priporočljivo uporabljati pri otrocih in mladostnikih, mlajših od 18 let.
English: Duzallo should be taken in the morning with food and water.
Slovenian: Način uporabe peroralna uporaba Zdravilo Duzallo je treba vzeti zjutraj s hrano in vodo.
English: This is also the maximum daily dose of Duzallo (see section 4.4).
Slovenian: To je tudi največji dnevni odmerek zdravila Duzallo (glejte poglavje 4.4).
English: Other medicines and Duzallo
Slovenian: Druga zdravila in zdravilo Duzallo
English: Increased TSH values (>5.5 μIU/mL) were observed in patients on long-term treatment with allopurinol (5.8%) in a long term open label extension study.
Slovenian: Zvišane vrednosti TSH (> 5,5 μIU/mL) so ugotovili pri bolnikih na dolgotrajnem zdravljenju z alopurinolom (5,8%) v dolgotrajni odprti podaljšani študiji.
English: Patients should be closely monitored for therapeutic response and theappearance of toxicity.
Slovenian: Bolnike je treba skrbno spremljati na učinkovitost zdravljenja in pojav toksičnosti.
English: Following multiple once daily dosing of lesinurad, there was no evidence of time dependent changes in pharmacokinetic properties and dose proportionality was preserved.
Slovenian: Po večkratnem odmerjanju lesinurada enkrat na dan ni prišlo do od časa odvisnih sprememb farmakokinetičnih lastnosti in sorazmernost odmerka se je ohranila.
English: Angina pectoris, bradycardia
Slovenian: Srčne bolezni angina pektoris, bradikardija
English: Do not take more than 1 tablet per day.
Slovenian: Ne vzemite več kot ene (1) tablete zdravila Duzallo na dan.
English: Patients with serum creatinine elevations to greater than 1.5 times the pre-treatment value should be closely monitored.
Slovenian: Bolnike z zvišanjem kreatinina v serumu na več kot 1,5-kratno vrednost, kot je bila pred zdravljenjem, je treba skrbno nadzorovati.
English: Clinical outcomes - concomitant use of thiazides
Slovenian: Klinični izidi - sočasna uporaba s tiazidi
English: This may decrease the therapeutic activity of Duzallo which contains the active substance allopurinol, but the significance needs to be assessed in each case.
Slovenian: To lahko zmanjša terapevtski učinek zdravila Duzallo, ki vsebuje učinkovino alopurinol, vendar je treba pomembnost tega preučiti pri vsakem primeru posebej.
English: If an overdose is suspected, patients should be managed by symptomatic and supportive care including adequate hydration.
Slovenian: V primeru prevelikega odmerjanja mora biti bolnik deležen simptomatskega in podpornega zdravljenja, vključno z ustrezno hidracijo.
English: The European Medicines Agency has waived the obligation to submit the results of studies with Duzallo in all subsets of the paediatric population for the treatment and prevention of hyperuricaemia (see section 4.2 for information on paediatric use).
Slovenian: Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij z zdravilom Duzallo za vse podskupine pediatrične populacije za zdravljenje in preprečevanje hiperurikemije (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
English: The safety of lesinurad 200 mg was evaluated in the Phase 3 combination therapy clinical trials (including extension studies).
Slovenian: Varnost lesinurada 200 mg so ocenili v kliničnih preskušanjih 3. faze s kombiniranim zdravljenjem (vključno s podaljšanimi študijami).
English: If this happens, keep taking Duzallo and talk to your doctor or pharmacist.
Slovenian: Če se to zgodi, še naprej jemljite zdravilo Duzallo in se posvetujte z zdravnikom ali farmacevtom.
English: Tumour lysis syndrome or Lesch-Nyhan syndrome.
Slovenian: Sindrom lize tumorja ali Lesch-Nyhanov sindrom.
English: Clinical outcomes - cardiovascular safety
Slovenian: Klinični izidi - srčno-žilna varnost
English: The apparent volume of distribution of allopurinol is approximately 1.6 litre/kg which, suggests relatively extensive uptake by tissues.
Slovenian: Volumen porazdelitve alopurinola je približno 1,6 l/kg, kar kaže na relativno obsežen privzem v tkiva.
English: *** Includes the terms: renal failure, renal failure chronic and renal failure acute.
Slovenian: *** Vključuje prednostne izraze: odpoved ledvic, kronična odpoved ledvic in akutna odpoved ledvic.
English: Across both studies, 61% of patients had mild or moderate renal impairment and 19% had tophi at baseline.
Slovenian: V obeh študijah je imelo 61% bolnikov blago ali zmerno okvaro ledvic in 19% jih je imelo tofe v izhodišču.
English: Therefore, it is recommended that patients are monitored for reduced efficacy of CYP2B6 substrates (e.g. bupropion, efavirenz) when co-administered with lesinurad.
Slovenian: Zato je bolnike priporočljivo nadzirati glede zmanjšane učinkovitosti substratov CYP2B6 (npr. bupropiona, efavirenza), kadar jih jemljejo sočasno z lesinuradom.
English: What Duzallo is and what it is used for
Slovenian: Kaj je zdravilo Duzallo in za kaj ga uporabljamo
English: This is because Duzallo can affect the way some other medicines work.
Slovenian: Zdravilo Duzallo namreč lahko vpliva na delovanje nekaterih drugih zdravil.
English: You may feel sick or be sick, feel dizzy or have diarrhoea.
Slovenian: Morda se boste slabo počutili, bruhali, počutili omotično ali imeli drisko.
English: In another patient the intake of 22.5 g allopurinol caused no adverse reactions.
Slovenian: Pri nekem drugem bolniku so poročali o zaužitju 22,5 g alopurinola brez neželenih učinkov.
English: SJS/TEN can still occur in patients who are found to be negative for HLA-B*5801 irrespective of their ethnic origin.
Slovenian: SJS/TEN se lahko pojavita tudi pri bolnikih, ki niso nosilci HLA-B*5801 alela in ne glede na njihovo etnično poreklo.
English: Investigations Blood thyroid stimulating hormone increased****, blood creatinine increased
Slovenian: Preiskave zvišanje ščitnico stimulirajoči hormona (TSH) v krvi****, zvišanje kreatinina v krvi
English: Corticosteroids may be beneficial in overcoming hypersensitivity skin reactions.
Slovenian: Uporaba kortikosteroidov pomaga pri zdravljenju preobčutljivostnih reakcij na koži.
English: However, individual values were well within the range observed in the extensive metaboliser subjects.
Slovenian: Toda individualne vrednosti so bile v okviru razpona, ugotovljenega pri izrazitih presnavljalcih.
English: When generalised hypersensitivity reactions have occurred, renal and/or hepatic disorder has usually been present particularly when the outcome has been fatal.
Slovenian: V primeru, da je prišlo do pojava generaliziranih preobčutljivostnih reakcij, so bile običajno prisotne motnje v delovanju ledvic in/ali jeter, še zlasti kadar je bil izid smrten.
English: In vitro and in vivo studies conducted to date showed no evidence of mutagenic or carcinogenic potential.
Slovenian: Dosedanje in vitro in in vivo študije niso dokazale mutagenosti ali karcinogenosti.
English: Ampicillin/amoxicillin
Slovenian: Ampicilin/amoksicilin
English: Not recommended concomitant use with:
Slovenian: Sočasna uporaba ni priporočljiva:
English: Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Slovenian: Bolniki z redko dedno intoleranco za galaktozo, odsotnostjo encima laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
English: Patients should be instructed to stay well hydrated.
Slovenian: Bolnikom je treba naročiti, da poskrbijo za dobro hidracijo.
English: Lesinurad 200 mg + allopurinol N=405
Slovenian: Lesinurad 200 mg + alopurinol N = 405
English: The effect of lesinurad and allopurinol on fertility in humans has not been studied.
Slovenian: Vpliv lesinurada in alopurinola na plodnost pri človeku ni raziskan.
English: In addition, lesinurad is an in vitro inducer of CYP2B6 and CYP3A via constitutive androstane receptor (CAR)/pregnane X receptor (PXR).
Slovenian: Poleg tega lesinurad in vitro inducira CYP2B6 in CYP3A preko konstitutivnega androstanskega receptorja (CAR-constitutive androstane receptor)/pregnanskega ksenobiotičnega receptorja (PXR-pregnane X receptor).
English: • people who have problems with their kidneys and take this medicine and a diuretic (a medicine that increases urine) at the same time
Slovenian: • ljudeh, ki imajo težave z ledvicami in jemljejo to zdravilo skupaj z diuretikom (zdravilo, ki povečuje količino seča).
English: The possibility of an increased occurrence of ciclosporin-specific adverse reactions is to be considered.
Slovenian: Upoštevati moramo možnost, da pride do povečane pojavnosti neželenih učinkov, ki so značilni za ciklosporin.
English: **** The occurrence of increased thyroid stimulating hormone (TSH) in the relevant studies did not report any impact on free T4 levels or had TSH levels indicative of subclinical hypothyroidism.
Slovenian: **** Zvišan ščitnico stimulirajoči hormon (TSH) v omenjenih študijah ni bil povezan s spremembami vrednosti prostega T4 in koncentracije TSH niso bile značilne za subklinični hipotiroidizem.
English: No dose adjustment is necessary based on age (see section 5.2); however, elderly patients are more likely to have decreased renal function (see dosing recommendations for renal impairment).
Slovenian: Odmerka ni treba prilagoditi glede na starost (glejte poglavje 5.2), vendar pa je pri starejših bolnikih bolj verjetno, da je delovanje ledvic zmanjšano (glejte priporočila za odmerjanje pri okvari ledvic).
English: An induction effect of lesinurad should be anticipated after 2 to 3 weeks of continuous co-administration of Duzallo.
Slovenian: Indukcijski učinek lesinurada pričakujemo po 2 do 3 tednih nepretrgane sočasne uporabe z zdravilom Duzallo.
English: Continuous treatment with Duzallo decreases the frequency of gout flares.
Slovenian: Trajno zdravljenje z zdravilom Duzallo zmanjša pogostnost napadov protina.
English: Coumarin anticoagulants
Slovenian: Kumarinski antikoagulanti
English: Your doctor will tell you if additional doses of allopurinol are still necessary.
Slovenian: Zdravnik vam bo povedal, ali morate še vedno jemati dodatne odmerke alopurinola.
English: The most common adverse reaction leading to discontinuation of lesinurad was blood creatinine increased (frequency 0.8%).
Slovenian: Najpogostejši neželeni učinek, ki je povzročil prenehanje zdravljenja z lesinuradom, je bilo zvišanje kreatinina v krvi (pogostnost 0,8%).
English: Evidence suggests that the plasma half-life of adenine arabinoside is increased in the presence of allopurinol and hence when these two active substances are administered concomitantly, extra vigilance is required to recognize enhanced toxic effects.
Slovenian: Podatki kažejo, da je razpolovni čas adenin arabinozida v plazmi v prisotnosti alopurinola povečan in zato moramo biti ob sočasnem jemanju teh dveh učinkovin še posebej pozorni, da prepoznamo bolj izražene toksične učinke.
English: Gout is a type of arthritis caused by the build-up of uric acid crystals around the joints.
Slovenian: Protin je vrsta artritisa, ki ga povzroča kopičenje kristalov sečne kisline okrog sklepov.
English: By lowering the amount of uric acid in the blood, Duzallo stops this build-up and may prevent further joint damage.
Slovenian: Z znižanjem količine sečne kisline v krvi zdravilo Duzallo ustavi to kopičenje in lahko prepreči nadaljnjo okvaro sklepov.
English: If such reactions do occur, it may be at any time during treatment, Duzallo should be withdrawn immediately and permanently.
Slovenian: Če kadarkoli med zdravljenjem pride do pojava takih reakcij, je treba takoj in trajno prenehati z jemanjem zdravila Duzallo.
English: Fluconazole, a moderate CYP2C9 inhibitor, increased lesinurad AUC (56%) and Cmax (38%), as well as the amount of lesinurad excreted unchanged in urine.
Slovenian: Flukonazol, zmeren zaviralec CYP2C9, je povečal AUC lesinurada (56%) in njegovo Cmax (38%), pa tudi količino lesinurada, ki se je nespremenjen izločil v urinu.
English: Opaque (PVC/PVdC/Aluminium) blister.
Slovenian: Neprozorni (PVC/PVdC/aluminij) pretisni omot.
English: In transplant patients frequent measurement of ciclosporin levels and, if necessary, ciclosporin dosage adjustment is required, particularly during the introduction or withdrawal of Duzallo.
Slovenian: Pri bolnikih s presadki moramo bolnikom pogosto izmeriti raven ciklosporina in odmerek ciklosporina po potrebi prilagoditi, še zlasti ob uvedbi ali prenehanju jemanja zdravila Duzallo.
English: The HLA-B*5801 allele has been shown to be associated with the risk of developing allopurinol related hypersensitivity syndrome and SJS/TEN.
Slovenian: HLA-B*5801 alel je povezan s tveganjem za nastanek z alopurinolom povezanega sindroma preobčutljivosti in SJS/TEN.
English: Within 7 days following single dosing of radiolabelled lesinurad, 63% of administered radioactive dose was recovered in urine and 32% of administered radioactive dose was recovered in faeces.
Slovenian: V 7 dneh po enkratnem odmerku radioaktivno označenega lesinurada se je 63% uporabljenega radioaktivnega odmerka pojavilo v urinu, 32% pa v blatu.
English: Rare - may affect up to 1 in 1000 people - disorder of the liver (hepatitis).
Slovenian: Redki - pojavijo se lahko pri največ 1 od 1.000 bolnikov - obolenje jeter (hepatitis).
English: However, since adverse reactions such as somnolence, vertigo and ataxia have been reported in patients receiving allopurinol (see section 4.8), patients should exercise caution before driving, using machinery or participating in dangerous activities until they are reasonably certain that Duzallo does not adversely affect their ability to drive and use machines.
Slovenian: Ker so pa pri bolnikih, ki so jemali alopurinol (glejte poglavje 4.8) poročali o neželenih učinkih, kot so somnolenca, vrtoglavica in ataksija, morajo bolniki biti previdni preden vozijo, upravljajo stroje ali sodelujejo pri nevarnih dejavnostih, dokler se ne prepričajo, da zdravilo Duzallo ne vpliva na njihovo sposobnost vožnje in upravljanja strojev.
English: Also some other medicines can affect the way Duzallo works.
Slovenian: Tudi nekatera druga zdravila lahko vplivajo na delovanje zdravila Duzallo.
English: If you develop a rash or any of these skin symptoms, stop taking this medicine and contact your doctor immediately.
Slovenian: Če pri vas pride do pojava izpuščajev ali teh kožnih simptomov, nemudoma prenehajte z jemanjem tega zdravila in se takoj posvetujte z zdravnikom.
English: The most commonly reported adverse reactions during treatment with lesinurad 200 mg are influenza, gastro-oesophageal reflux disease, headache and blood creatinine increased.
Slovenian: Najpogosteje poročani neželeni učinki med zdravljenjem z lesinuradom 200 mg so gripa, gastroezofagealna refluksna bolezen, glavobol in zvišanje kreatinina v krvi.
English: There are no data from the use of lesinurad and limited amount of data from the use of allopurinol in pregnant women.
Slovenian: Podatkov o uporabi lesinurada pri nosečnicah ni, podatki o uporabi alopurinola pa so omejeni.
English: These serious skin rashes often come after flu-like symptoms such as fever, headache, body ache.
Slovenian: Pogosto se ti resni kožni izpuščaji pojavijo po znakih, ki so podobni simptomom gripe, kot so zvišana telesna temperatura, glavobol in bolečine v telesu.
English: Allopurinol hypersensitivity reactions can manifest in many different ways, including maculopapular exanthema, hypersensitivity syndrome (also known as DRESS) and SJS/TEN.
Slovenian: Preobčutljivostne reakcije, ki jih povzroča alopurinol, se lahko kažejo na mnogo različnih načinov, vključno z makulopapularnim eksantemom, sindromom preobčutljivosti (poznanim tudi kot DRESS) in SJS/TEN.
English: Kidney problems If you notice any of the following side effects, stop taking Duzallo and see a doctor immediately as these may be signs of a problem with your kidneys - you may need urgent medical treatment.
Slovenian: Če opazite katerega od naslednjih neželenih učinkov, nehajte jemati zdravilo Duzallo in takoj obiščite zdravnika, kajti to so lahko znaki težav z ledvicami - morda boste potrebovali nujno medicinsko pomoč.
English: The rash can involve ulcers of the mouth, throat, nose, genitals and conjunctivitis (red and swollen eyes).
Slovenian: Izpuščaji lahko vključujejo razjede v ustih, grlu, nosu, spolovilih in konjunktivitis (rdeče in otekle oči).
English: Based on interaction studies in healthy subjects or gout patients, lesinurad does not have clinically significant interactions with NSAIDs (naproxen and indomethacin) or colchicine.
Slovenian: Na podlagi študij medsebojnega delovanja pri zdravih osebah in bolnikih s protinom, lesinurad nima klinično pomembnih medsebojnih delovanj z NSAID (naproksen in indometacin) in kolhicinom.
English: Angiotensin-converting-enzyme (ACE) inhibitors
Slovenian: Zaviralci angiotenzinske konvertaze (ACE)
English: Renal function should be evaluated prior to initiation of Duzallo and monitored periodically thereafter (e. g. 4 times per year), based on clinical considerations, such as baseline renal function, volume depletion, concurrent illness or concomitant medicinal products.
Slovenian: Delovanje ledvic je treba oceniti pred uvedbo zdravila Duzallo in ga nadzirati redno (npr. 4-krat na leto) med zdravljenjem glede na klinične okoliščine, kot so izhodiščno delovanje ledvic, zmanjšanje volumna, sočasne bolezni ali sočasna zdravila.
English: Iron oxide yellow (E172) Iron oxide red (E172)
Slovenian: rdeči železov oksid (E172)
English: However, it is recommended that in patients receiving Duzallo which contains the active substance allopurinol an alternative to ampicillin or amoxicillin is used where available.
Slovenian: Vseeno se priporoča, da bolniki, ki prejemajo zdravilo Duzallo, ki vsebuje učinkovino alopurinol, uporabljajo alternativo za ampicilin ali amoksicilin, kadar je to mogoče.
English: Clinical outcomes - renal events
Slovenian: Klinični izidi - ledvični dogodki
English: Extra vigilance for signs of hypersensitivity syndrome or SJS/TEN is required and the patient should be informed of the need to stop treatment immediately at the first appearance of symptoms.
Slovenian: Nujno je biti še posebno pozoren na znake sindroma preobčutljivosti in SJS/TEN in bolnika opozoriti, da ob prvem pojavu simptomov nemudoma prekine zdravljenje.
English: Duzallo tablets contain lactose (a type of sugar).
Slovenian: Tablete zdravila Duzallo vsebujejo laktozo (vrsto sladkorja).
English: Your doctor may stop Duzallo if your blood tests show changes in how your kidneys are working or if you have symptoms of kidney problems.
Slovenian: Zdravnik bo morda ukinil zdravljenja z zdravilom Duzallo, če bodo preiskave krvi pokazale spremenjeno delovanje ledvic ali če se pri vas pojavijo simptomi težav z ledvicami.