FrancophonIA/ELRC3.0 huggingface dataset:
English: If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Croatian: Primijetite li bilo koje simptome infekcije ili druge simptome poput mišićne slabosti, slabosti koja počinje u šakama i stopalima i penje se prema trupu, lupanje srca, drhtanje ili pretjeranu aktivnost, odmah o tome obavijestite svog liječnika i zatražite potrebno liječenje.
English: The pharmacokinetics of ritonavir remained unchanged.
Croatian: Farmakokinetika ritonavira nije se promijenila.
English: • ergot alkaloids - for migraine attacks
Croatian: • ergot alkaloide - koriste se za liječenje migrenskih napadaja
English: Do not take Invirase if you have:
Croatian: Nemojte uzimati Invirase:
English: Endothelin receptor antagonist Bosentan
Croatian: Antagonisti endotelinskih receptora Bosentan
English: Distribution studies in these species showed that the placental transfer of saquinavir is low (less than 5% of maternal plasma concentrations).
Croatian: Ispitivanja raspodjele na navedenim vrstama pokazala su da je razina prijenosa sakvinavira kroz posteljicu niska (manje od 5% koncentracije u majčinoj plazmi).
English: Genotypic and phenotypic clinical cut-offs predicting the clinical efficacy of ritonavir boosted saquinavir have been derived from retrospective analyses of the RESIST 1 and 2 clinical studies and analysis of a large hospital cohort (Marcelin et al 2007).
Croatian: Genotipske i fenotipske kliničke značajke prema kojima se može predvidjeti klinička djelotvornost liječenja sakvinavirom uz potporu ritonavira utvrđene su pomoću retrospektivne analize kliničkih ispitivanja RESIST 1 i 2 kao i analize velike bolničke kohorte (Marcelin i sur. 2007).
English: Initiated assigned treatment, n (%)
Croatian: Započeto propisano liječenje, n (%)
English: Infection: In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after antiHIV treatment is started.
Croatian: Infekcija: U nekih bolesnika s uznapredovalom HIV infekcijom (AIDS) koji su već imali oportunističke infekcije, znakovi i simptomi upale iz prijašnjih infekcija mogu nastupiti ubrzo nakon početka anti-HIV liječenja.
English: Clinical results from paediatric studies
Croatian: Klinički rezultati pedijatrijskih ispitivanja
English: ECG and PK measurements were collected on Days 3, 4, 7, 10, and 14 of treatment with the modified Invirase/ritonavir treatment.
Croatian: EKG i farmakokinetički parametri prikupljeni su 3., 4., 7., 10. i 14. dan liječenja modificiranom terapijom lijekovima Invirase/ritonavir.
English: Absolute bioavailability averaged 4 % (CV 73 %, range: 1 % to 9 %) in 8 healthy volunteers who received a single 600 mg dose (3 x 200 mg hard capsule) of Invirase following a heavy breakfast.
Croatian: Prosječna apsolutna bioraspoloživost iznosila je 4% (CV 73%, raspon: 1% do 9%) u 8 zdravih dobrovoljaca koji su primili jednu dozu od 600 mg (3 x 200 mg tvrdih kapsula) lijeka Invirase nakon obilnog doručka.
English: It is recommended that HIV-infected women do not breast feed their infants under any circumstances in order to avoid transmission of HIV.
Croatian: Preporučuje se da žene zaražene HIV-om ne doje svoju djecu kako bi se izbjegla mogućnost prijenosa HIV-a.
English: The study included a control group consisting of 7 HIV-infected patients with normal hepatic function matched with the hepatically impaired patients for age, gender, weight and tobacco use.
Croatian: Ispitivanje je imalo i kontrolnu skupinu od 7 bolesnika zaraženih HIV-om s normalnom jetrenom funkcijom, koji su se s bolesnicima s oštećenjem jetrene funkcije slagali po dobi, spolu, tjelesnoj masi i uporabi duhanskih proizvoda.
English: Saquinavir selectively inhibits the HIV protease, thereby preventing the creation of mature infectious virus particles.
Croatian: Sakvinavir selektivno inhibira HIV proteazu te tako sprječava stvaranje zrelih infektivnih virusnih čestica.
English: Other medicinal products Alpha-1 adrenoreceptor antagonist Alfuzosin
Croatian: Antagonisti alfa-1 adrenoreceptora Alfuzozin
English: • certain medicines (so called tyrosine kinase inhibitors) used to treat different types of cancer such as dasatinib and sunitinib.
Croatian: • nekih lijekova (takozvanih inhibitora tirozin kinaze) koji se koriste za liječenje različitih vrsta raka, poput dasatiniba i sunitiniba
English: The association between the number of these saquinavir-associated resistance mutations and virological response was confirmed in an independent clinical study (RESIST 1 and 2) involving a more heavily treatment experienced patient population, including 54% who had received prior saquinavir (p=0.0133, see Table 5).
Croatian: Veza između broja tih mutacija povezanih s otpornošću na sakvinavir i virološkog odgovora potvrđena je u neovisnom kliničkom ispitivanju (RESIST 1 i 2) koje je obuhvaćalo populaciju prethodno liječenih bolesnika, uključujući 54% bolesnika koji su prethodno primali sakvinavir (p=0,0133, vidjeti Tablicu 5).
English: • congenital or documented acquired QT prolongation
Croatian: • s urođenim ili dokumentiranim stečenim produljenjem QT-intervala
English: • certain medicines for severe mental health problems such as pimozide
Croatian: • nekih lijekova za teške psihičke poremećaje, poput pimozida
English: Reproductive toxicity: Fertility, peri- and postnatal development were not affected, and embryotoxic / teratogenic effects were not observed in rats or rabbits at plasma exposures lower than those achieved in humans at the recommended clinical dose of ritonavir boosted Invirase.
Croatian: Reproduktivna toksičnost: Nije bilo utjecaja na plodnost, perinatalni i postnatalni razvoj i nisu opaženi embriotoksični/teratogeni učinci u štakora i zečeva pri izloženosti u plazmi manjoj od one koja se postiže u ljudi pri preporučenoj dozi lijeka Invirase pojačanog ritonavirom.
English: • Essential Patient Information: Prescribers must ensure that patients are fully informed regarding the following information on cardiac conduction and repolarisation abnormalities: - Patients initiating therapy with ritonavir boosted Invirase should be warned of the arrhythmogenic risk associated with QT and PR prolongation and told to report any sign or symptom suspicious of cardiac arrhythmia (e.g., chest palpitations, syncope, presyncope) to their physician.
Croatian: • Neophodne informacije za bolesnike: Propisivači lijeka moraju osigurati potpunu informiranost bolesnika o sljedećim podacima koji se tiču poremećaja srčane provodljivosti i repolarizacije: - Bolesnike koji započinju liječenje lijekom Invirase pojačanim ritonavirom treba upozoriti na aritmogeni rizik povezan s produljenjem QT ili PR-intervala i reći im da svom liječniku prijave svaki znak ili simptom koji ukazuje na srčanu aritmiju (npr. palpitacije u prsnom košu, sinkopa, presinkopa).
English: A decrease in the dose of the benzodiazepine may be required.
Croatian: Možda će biti potrebno sniziti dozu benzodiazepina.
English: When used with Invirase/ritonavir, the lowest possible dose of atorvastatin should be administered and the patient should be carefully monitored for signs/symptoms of myopathy (muscle weakness, muscle pain, rising plasma creatinine kinase, see section 4.4).
Croatian: Kad se koristi s lijekovima Invirase/ritonavir, mora se primijeniti najniža moguća doza atorvastatina te pomno nadzirati bolesnika kako bi se uočili eventualni znakovi/simptomi miopatije (mišićna slabost, bol u mišićima, povećana razina kreatin kinaze, vidjeti dio 4.4).
English: There is no specific antidote for overdose with saquinavir.
Croatian: Nema specifičnog antidota za predoziranje sakvinavirom.
English: Haloperidol Chlorpromazine Mesoridazine Phenothiazines Sertindole
Croatian: Haloperidol Klorpromazin Mesoridazin Fenotiazini Sertindol
English: Long-acting beta2-adrenergic agonist Salmeterol
Croatian: Dugodjelujući beta2-adrenergički agonist Salmeterol
English: • antifungals - ketoconazole, itraconazole, fluconazole, miconazole
Croatian: • antimikotike - ketokonazol, itrakonazol, flukonazol, mikonazol
English: Paediatric Patients: Steady state pharmacokinetic information is available from HIV-infected paediatric patients from study NV20911.
Croatian: Pedijatrijski bolesnici: Informacije o farmakokinetici u stanju dinamičke ravnoteže u pedijatrijskih bolesnika zaraženih HIV-om dostupne su iz ispitivanja NV20911.
English: Change in Baseline Plasma HIV-1 RNA at Weeks 12-20
Croatian: Promjena početne HIV-1 RNA u plazmi u tjednima 12-20
English: The Day 3 timepoint was chosen since the pharmacokinetic exposure was maximum on that day in a previous 14-day multiple dose pharmacokinetic study.
Croatian: Treći dan odabran je za mjernu točku stoga što je toga dana u prethodnom 14-dnevnom farmakokinetičkom ispitivanju višestrukih doza zabilježena najveća farmakokinetička izloženost.
English: In two patients receiving Invirase 600 mg three times daily, cerebrospinal fluid concentrations of saquinavir were negligible when compared to concentrations from matching plasma samples.
Croatian: U dva bolesnika koja su primala Invirase u dozi od 600 mg triput na dan koncentracije sakvinavira u cerebrospinalnoj tekućini bile su zanemarive u odnosu na koncentracije iz odgovarajućih uzoraka plazme.
English: Careful monitoring of patients with regard to sedative effects is warranted.
Croatian: Preporučuje se poman nadzor bolesnika s obzirom na sedativne učinke.
English: Increased concentrations of indinavir may result in nephrolithiasis.
Croatian: Povišene koncentracije indinavira mogu dovesti do nefrolitijaze.
English: Invirase with food and drink Invirase must be taken together with ritonavir and with or after food.
Croatian: Invirase s hranom i pićem Invirase se mora uzimati zajedno s ritonavirom, uz obrok ili nakon njega.
English: • a very slow heart rate (bradycardia)
Croatian: • ako imate jako usporene otkucaje srca (bradikardija)
English: Clinical results from studies with treatment naïve and experienced patients
Croatian: Klinički rezultati ispitivanja s prethodno neliječenim i prethodno liječenim bolesnicima
English: The proportion of patients with a reported PR interval prolongation > 200 ms in this study ranged from 3/22 (14%) (day 3) to 8/21 (38%) (day14).
Croatian: U ovome se ispitivanju udio bolesnika u kojih je prijavljeno produljenje PR-intervala od > 200 ms kretao u rasponu od 3/22 (14%) (3. dan) do 8/21 (38%) (14. dan).
English: Saquinavir does not induce chromosomal damage in vivo in the mouse micronucleus assay or in vitro in human peripheral blood lymphocytes and does not induce primary DNA damage in vitro in the unscheduled DNA synthesis test.
Croatian: Sakvinavir ne uzrokuje oštećenje kromosoma in vivo u mikronukleusnom testu na miševima niti in vitro u ljudskim limfocitima periferne krvi i ne uzrokuje primarno oštećenje DNA in vitro u testu nepredviđene sinteze DNA.
English: In a clinical study 11 of 17 (65 %) healthy volunteers developed severe hepatocellular toxicity with transaminase elevations up to > 20fold the upper limit of normal after 1 to 5 days of co-administration.
Croatian: U kliničkom se ispitivanju u 11 od 17 (65%) zdravih dobrovoljaca razvila teška hepatocelularna toksičnost, uz povišenje vrijednosti transaminaza do > 20 puta iznad gornje granice normale nakon 1 do 5 dana istodobne primjene.
English: Hepatocellular changes should be monitored frequently if this combination is prescribed.
Croatian: Ako se propisuje ova kombinacija treba često kontrolirati hepatocelularne promjene.
English: Tacrolimus may be associated with torsades de pointes.
Croatian: Takrolimus može biti povezan s torsades de pointes.
English: Distribution in adults: Saquinavir partitions extensively into the tissues.
Croatian: Distribucija u odraslih: Sakvinavir se u velikoj mjeri raspodjeljuje u tkiva.
English: Mutagenesis: Mutagenicity and genotoxicity studies, with and without metabolic activation where appropriate, have shown that saquinavir has no mutagenic activity in vitro in either bacterial (Ames test) or mammalian cells (Chinese hamster lung V79/HPRT test).
Croatian: Mutagenost: Istraživanja mutagenosti i genotoksičnosti, s ili bez metaboličke aktivacije, prema potrebi, pokazala su da sakvinavir in vitro ne djeluje mutageno ni na bakterijske (Ames test) ni na stanice sisavaca (HPRT test na stanicama pluća kineskog hrčka V79).
English: Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to combination antiretroviral therapy (CART).
Croatian: Prijavljeni su slučajevi osteonekroze, osobito u bolesnika s opće poznatim faktorima rizika, uznapredovalom HIV bolešću i/ili izloženih dugotrajnoj kombiniranoj antiretrovirusnoj terapiji (CART).
English: Following intravenous administration 66 % of circulating saquinavir was present as unchanged compound and the remainder as metabolites, suggesting that saquinavir undergoes extensive first pass metabolism.
Croatian: Nakon intravenske se primjene 66% sakvinavira u cirkulaciji nalazilo u obliku nepromijenjenog spoja, a ostatak u obliku metabolita, što upućuje na to da sakvinavir podliježe ekstenzivnom metabolizmu prvog prolaza.
English: Also, changes in laboratory markers (e.g., blood or urine tests) have been reported very commonly.
Croatian: Vrlo su često prijavljene i promjene u laboratorijskim pokazateljima (npr. pretragama krvi ili mokraće).
English: Adverse reactions are presented according to the MedDRA system organ classification.
Croatian: Nuspojave su prikazane prema MedDRA klasifikaciji organskih sustava.
English: Enfuvirtide ↔
Croatian: Enfuvirtid ↔
English: Patients should be informed that saquinavir is not a cure for HIV infection and that they may continue to acquire illnesses associated with advanced HIV infection, including opportunistic infections.
Croatian: Bolesnici trebaju znati da sakvinavir neće izliječiti HIV infekciju te da će možda i dalje obolijevati od bolesti povezanih s uznapredovalom HIV infekcijom, uključujući oportunističke infekcije.
English: You should know that Invirase/ritonavir is not a cure for HIV infection and that you may continue to develop infections or other illnesses associated with HIV disease.
Croatian: Morate znati da lijekovi Invirase/ritonavir neće potpuno izliječiti HIV infekciju te se i dalje mogu javljati infekcije ili druge bolesti povezane s HIV bolešću.
English: The G48V mutation, previously identified in vitro as a saquinavir signature mutation, was present at baseline in virus from three patients, none of whom responded to therapy.
Croatian: Mutacija G48V, koja je ranije in vitro prepoznata kao značajna mutacija povezana sa sakvinavirom, bila je na početku liječenja prisutna u virusu tri bolesnika, od kojih niti jedan nije odgovorio na liječenje.
English: • medicines used to treat high blood pressure in the arteries of the lungs (a disease known as pulmonary arterial hypertension) such as bosentan.
Croatian: • lijekove za liječenje visokoga krvnog tlaka u plućnim arterijama (bolest poznata pod nazivom plućna arterijska hipertenzija), poput bosentana
English: Dose of maraviroc should be decreased to 150 mg bid with monitoring.
Croatian: Dozu maraviroka treba smanjiti na 150 mg dvaput na dan uz nadzor.
English: Medicinal products that are substrates of P-glycoprotein Digitalis glycosides
Croatian: Lijekovi koji su supstrati P-glikoproteina Glikozidi digitalisa
English: Therefore, when saquinavir is co-administered with ritonavir, consideration should be given to the potential effects of ritonavir on other medicinal products (see the Summary of Product Characteristics for Norvir).
Croatian: Stoga, kad se sakvinavir primjenjuje istodobno s ritonavirom, treba razmotriti i moguće učinke ritonavira na druge lijekove (vidjeti Sažetak opisa svojstava lijeka za Norvir).
English: Discontinued assigned treatment, n (%)
Croatian: Prekinuto propisano liječenje, n (%)
English: Saquinavir AUC ↓ 24% Nevirapine AUC ↔
Croatian: - Sakvinavir AUC ↓ 24% Nevirapine AUC ↔
English: • lurasidone - used to treat schizophrenia.
Croatian: • lurasidon - koristi se za liječenje shizofrenije
English: Invirase is indicated for the treatment of HIV-1 infected adult patients.
Croatian: Invirase je indiciran za liječenje odraslih bolesnika zaraženih virusom HIV-1.
English: Systemic clearance of saquinavir was high, 1.14 l/h/kg (CV 12 %), slightly above the hepatic plasma flow, and constant after intravenous doses of 6, 36 and 72 mg.
Croatian: Sistemski klirens sakvinavira je visok: 1,14 l/h/kg (CV 12%), malo veći od protoka plazme kroz jetru, te konstantan nakon intravenskih doza od 6, 36 i 72 mg.
English: The plasma exposures (AUC values) in rats (maximum dose 1000 mg/kg/day) and in mice (maximum dose 2500 mg/kg/day) were lower than the expected plasma exposures obtained in humans at the recommended clinical dose of ritonavir boosted Invirase.
Croatian: Izloženost u plazmi (vrijednosti AUC) u štakora (maksimalna doza 1000 mg/kg/dan) i miševa (maksimalna doza 2500 mg/kg/dan) bila je manja od očekivane izloženosti u plazmi koja se postiže u ljudi pri preporučenoj kliničkoj dozi lijeka Invirase pojačanog ritonavirom.
English: Table 6: Subject Demographics MaxCmin1 and MaxCmin2†
Croatian: Tablica 6: Demografske karakteristike ispitanika u ispitivanjima MaxCmin1 i MaxCmin2† MaxCmin1
English: • concurrent therapy with any of the following drugs, which may interact and result in potentially life-threatening undesirable effects (see sections 4.4, 4.5 and 4.8): - drugs that prolong the QT and/or PR interval (see sections 4.4 and 4.5) - midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5), triazolam (potential for prolonged or increased sedation, respiratory depression) - simvastatin, lovastatin (increased risk of myopathy including rhabdomyolysis) - ergot alkaloids (e.g. ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (potential for acute ergot toxicity) - rifampicin (risk of severe hepatocellular toxicity) (see sections 4.4, 4.5, and 4.8) - quetiapine (risk of coma, see section 4.5).
Croatian: • koji istodobno uzimaju neki od sljedećih lijekova, koji mogu ulaziti u interakcije i dovesti do nuspojava koje mogu biti opasne po život (vidjeti dijelove 4.4, 4.5 i 4.8): - lijekove koji produljuju QT i/ili PR-interval (vidjeti dijelove 4.4 i 4.5) - midazolam primijenjen peroralno (za mjere opreza kod parenteralne primjene midazolama, vidjeti dio 4.5), triazolam (mogućnost produljene ili pojačane sedacije, respiratorne depresije) - simvastatin, lovastatin (povećan rizik od miopatije, uključujući rabdomiolizu) - ergot alkaloide (npr. ergotamin, dihidroergotamin, ergonovin i metilergonovin) (mogućnost akutne toksičnosti ergota) - rifampicin (rizik od teške hepatocelularne toksičnosti) (vidjeti dijelove 4.4, 4.5, i 4.8). - kvetiapin (rizik od kome, vidjeti dio 4.5) - lurasidon (mogućnost pojave ozbiljnih i/ili po život opasnih reakcija, vidjeti dio 4.5)
English: There are also some medicines that require dosage reduction of that medicine or Invirase or ritonavir (see section “Medicines that can interact with saquinavir or ritonavir include:” below).
Croatian: Postoje i neki lijekovi zbog kojih se mora smanjiti doza tih lijekova ili lijeka Invirase ili ritonavira (vidjeti odlomak „Lijekovi koji mogu uzajamno djelovati sa sakvinavirom ili ritonavirom uključuju:“ u nastavku).
English: Cobicistat is not recommended in combination with regimens containing ritonavir due to similar effects of cobicistat and ritonavir on CYP3A.
Croatian: Primjena kobicistata nije preporučena u kombinaciji s režimima liječenja koji sadrže ritonavir zbog sličnog učinka kobicistata i ritonavira na CYP3A.
English: Table 10: Pharmacokinetic parameters of saquinavir at steady-state in HIV-infected pediatric patients
Croatian: Tablica 10: Farmakokinetički parametri sakvinavira u stanju dinamičke ravnoteže u pedijatrijskih bolesnika zaraženih HIV-om
English: Other medicinal products known to increase the plasma concentration of ritonavir-boosted Invirase should be used with caution.
Croatian: Druge lijekove za koje se zna da povećavaju koncentraciju lijeka Invirase pojačanog ritonavirom u plazmi treba primjenjivati uz oprez.
English: Ritonavir ↓ (effectiveness as boosting agent not modified).
Croatian: Ritonavir ↓ (nije promijenjena djelotvornost ritonavira kao pojačivača)
English: Invirase film-coated tablets should be swallowed whole and taken at the same time as ritonavir with or after food (see section 5.2).
Croatian: Invirase kapsule moraju se progutati cijele i uzimati u isto vrijeme kao i ritonavir, uz obrok ili poslije njega (vidjeti dio 5.2).
English: The combination of Invirase/ritonavir with drugs known to increase the exposure of saquinavir is not recommended and should be avoided when alternative treatment options are available.
Croatian: Kombinacija lijekova Invirase/ritonavir s lijekovima za koje se zna da povećavaju izloženost sakvinaviru se ne preporučuje i treba je izbjegavati ako postoje druge mogućnosti liječenja.
English: Consideration should be given for performing baseline and follow-up electrocardiograms after initiation of treatment, e.g. in patients taking concomitant medication known to increase the exposure of saquinavir (see section 4.5).
Croatian: Treba razmotriti snimanje početnog i kontrolnih elektrokardiograma nakon započinjanja liječenja, npr. u bolesnika koji istodobno uzimaju lijekove koji povećavaju izloženost sakvinaviru (vidjeti dio 4.5).
English: Co-administration of saquinavir and ritonavir has led to severe adverse events, mainly diabetic ketoacidosis and liver disorders, especially in patients with preexisting liver disease.
Croatian: Istodobna primjena sakvinavira i ritonavira dovela je do teških štetnih događaja, uglavnom dijabetičke ketoacidoze i poremećaja jetrene funkcije, osobito u bolesnika s postojećom bolešću jetre.
English: Change in Baseline Plasma HIV-1 RNA at Week 4
Croatian: Promjena početne HIV-1 RNA u plazmi u tjednu 4
English: Bone problems: Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
Croatian: Tegobe s kostima: U nekih bolesnika koji uzimaju kombiniranu antiretrovirusnu terapiju može se razviti bolest kostiju koja se zove osteonekroza (propadanje koštanog tkiva zbog prestanka opskrbe kosti krvlju).
English: Saquinavir AUC ↑ 348%.
Croatian: - Sakvinavir AUC ↑ 348%.
English: Tyrosine kinase inhibitors All tyrosine kinase inhibitors with a risk of QT prolongation e.g. dasatinib, sunitinib
Croatian: Inhibitori tirozin kinaze Svi inhibitori tirozin kinaze kod kojih postoji rizik od produljenja QT-intervala, npr. dasatinib, sunitinib
English: How to take Invirase
Croatian: Kako uzimati Invirase
English: Invirase contains the active substance saquinavir which is an antiviral agent.
Croatian: Invirase sadrži djelatnu tvar sakvinavir koji je antivirusni lijek.
English: Invirase/ritonavir may increase concentrations of tricyclic antidepressants.
Croatian: Lijekovi Invirase/ritonavir mogu povisiti koncentracije tricikličkih antidepresiva.
English: The clinical relevance of these findings from this study in healthy volunteers to the use of Invirase/ritonavir in HIV-infected patients is unclear, but doses exceeding Invirase/ritonavir 1000/100 mg twice daily should be avoided.
Croatian: Klinički značaj tih nalaza iz ovog ispitivanja provedenog u zdravih dobrovoljaca za primjenu lijekova Invirase/ritonavir u bolesnika zaraženih HIV-om nije jasan, ali treba izbjegavati doze lijekova Invirase/ritonavir veće od 1000/100 mg dvaput na dan.