FrancophonIA/ELRC3.0 huggingface dataset:
English: Decreased testicular weights and hypospermia were present in rats after repeat doses 0.25mg/kg/day and diffuse degeneration of the seminiferous tubules and a marked decrease in spermatogenesis were observed in dogs after repeat doses of 1 mg/kg/day (see section 4.6).
Croatian: Smanjena težina testisa i hipospermija bile su prisutne u štakora nakon ponovljenih doza  0,25 mg/kg na dan, a difuzna degeneracija sjemenih kanalića i izrazito smanjenje spermatogeneze uočeno je u pasa nakon ponovljene doze od 1 mg/kg na dan (vidjeti dio 4.6).
English: At equivalent doses, the plasma concentration and AUC values of Caelyx which represent mostly pegylated liposomal doxorubicin hydrochloride (containing 90% to 95% of the measured doxorubicin) are significantly higher than those achieved with standard doxorubicin hydrochloride preparations.
Croatian: U ekvivalentnim dozama, vrijednosti plazmatske koncentracije i AUC Caelyxa koje uglavnom predstavljaju pegilirani liposomalni doksorubicinklorid (sadrži 90% do 95% izmjerenog doksorubicina), značajno su veće od onih koje se postižu standardnim pripravcima doksorubicinklorida.
English: At cumulative doses greater than 450 mg/m2 there were no cardiac events with Caelyx.
Croatian: U kumulativnim dozama većima od 450 mg/m2 nije bilo srčanih poremećaja uz Caelyx.
English: Pyridoxine at a dose of 50-150 mg per day and corticosteroids have been used for the prophylaxis and treatment of PPE, however, these therapies have not been evaluated in phase III trials.
Croatian: Za profilaksu i liječenje PPE primjenjivani su piridoksin u dozi od 50 - 150 mg na dan i kortikosteroidi, međutim, ova liječenja nisu ocjenjivana u ispitivanjima faze III.
English: On the basis of the scientific conclusions for doxorubicin the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing doxorubicin is unchanged subject to the proposed changes to the product information.
Croatian: Na temelju znanstvenih zaključaka za doksorubicin, CHMP smatra da je omjer koristi i rizika lijeka(ova) koji sadrži(e) doksorubicin nepromijenjen, uz predložene izmjene informacija o lijeku.
English: Chemical and physical in-use stability has been demonstrated for 24 hours at 2°C to 8°C.
Croatian: Dokazana kemijska i fizikalna stabilnost lijeka u primjeni je 24 sata na temperaturi od 2 °C do 8 °C.
English: It did not interfere with patients completing therapy and no dosage adjustments are generally required, unless stomatitis is affecting a patient's ability to eat.
Croatian: To nije spriječilo dovršavanje liječenja u tih bolesnika i obično nije bilo potrebno smanjivati dozu, osim ako zbog stomatitisa bolesnik nije mogao jesti.
English: As doxorubicin is metabolised by the liver and excreted in the bile, dose modification should not be required.
Croatian: Budući da se doksorubicin metabolizira u jetri i izlučuje putem žuči, nije potrebno prilagođivati dozu.
English: Persistent severe myelosuppression, may result in superinfection or haemorrhage.
Croatian: Trajna teška mijelosupresija može dovesti do superinfekcije ili krvarenja.
English: Cardiac toxicity was defined as a decrease of 20 points or greater from baseline if the resting LVEF remained in the normal range or a decrease of 10 points or greater if the LVEF became abnormal (less than the lower limit for normal).
Croatian: Kardiotoksičnost je bila definirana kao smanjenje za 20 ili više bodova u odnosu na početno stanje ako je LVEF u mirovanju i dalje bio u normalnom rasponu, ili kao smanjenje za 10 ili više bodova ako je došlo do promjene LVEF (ispod donje granice normale).
English: Doxorubicin hydrochloride is suspected to cause serious birth defects when administered during pregnancy.
Croatian: Postoji sumnja da doksorubicinklorid uzrokuje ozbiljne urođene mane kad se primjenjuje tijekom trudnoće.
English: Dry skin
Croatian: Često suha koža
English: Caelyx, like other doxorubicin hydrochloride preparations, may potentiate the toxicity of other anti-cancer therapies.
Croatian: Caelyx, kao i drugi pripravci doksorubicinklorida, mogu pojačati toksičnost drugih antitumorskih terapija.
English: Reduction in haemoglobin and platelets were less frequently (< 5%) reported.
Croatian: Smanjenje hemoglobina i trombocita zabilježeno je manje često (< 5%).
English: If Caelyx comes into contact with skin or mucosa, wash immediately and thoroughly with soap and water.
Croatian: Ako Caelyx dođe u dodir s kožom ili sluznicama, odmah temeljito isperite vodom i sapunom.
English: Secondary haematological malignancies
Croatian: Sekundarne hematološke zloćudne bolesti
English: Clinically significant laboratory abnormalities frequently ( 5%) occurred including increases in alkaline phosphatase; AST and bilirubin which were believed to be related to the underlying disease and not Caelyx.
Croatian: Klinički značajni laboratorijski poremećaji bili su česti ( 5%), uključujući povećanje razine alkalne fosfataze, AST i bilirubina za koje se vjeruje da je povezano s osnovnom bolešću, a ne Caelyxom.
English: During clinical trials in patients with solid tumours (including breast and ovarian cancer) who have received concomitant cyclophosphamide or taxanes, no new additive toxicities were noted.
Croatian: Za vrijeme kliničkih ispitivanja u bolesnica sa solidnim tumorima (uključujući karcinom dojke i jajnika), koje su istovremeno primale ciklofosfamid ili taksane, nisu primijećeni nikakvi dodatni znakovi toksičnosti.
English: Breast cancer n=404
Croatian: Karcinom dojke n=404
English: Other strategies to prevent and treat PPE include keeping hands and feet cool, by exposing them to cool water (soaks, baths, or swimming), avoiding excessive heat/hot water and keeping them unrestricted (no socks, gloves, or shoes that are tight fitting).
Croatian: Druge metode sprječavanja i liječenja PPE uključuju hlađenje šaka i stopala izlaganjem hladnoj vodi (namakanje, kupke ili plivanje), izbjegavanje pretjerane topline/vruće vode i nepokrivanje (ne nositi čarape, rukavice ili uske cipele).
English: Caelyx contains soya oil and sodium
Croatian: Caelyx sadrži sojino ulje i natrij
English: Sepsis related to leukopaenia was rarely (< 1%) observed.
Croatian: Sepsa povezana s leukopenijom rijetko je bila primijećena (< 1%).
English: The primary analysis of cardiac toxicity showed the risk of developing a cardiac event as a function of cumulative anthracycline dose was significantly lower with Caelyx than with doxorubicin (HR=3.16, p < 0.001).
Croatian: Primarna analiza kardiotoksičnosti pokazala je da je rizik od razvoja srčanog poremećaja kao posljedice kumulativne doze antraciklina bio značajno niži uz Caelyx nego doksorubicin (HR=3,16, p < 0,001).
English: - For treatment of AIDS-related Kaposi's sarcoma (KS) in patients with low CD4counts (< 200 CD4 lymphocytes/mm
Croatian: - Za liječenje Kaposijevog sarkoma povezanog s AIDS-om u bolesnika s niskim brojem CD4 stanica (< 200 CD4 limfocita/mm
English: Do not use material that shows evidence of precipitation or any other particulate matter.
Croatian: Nemojte koristiti materijal koji pokazuje znakove taloženja ili sadrži neke druge čestice.
English: In patients with AIDS, exacerbation of cyclophosphamide-induced haemorrhagic cystitis and enhancement of the hepatotoxicity of 6-mercaptopurine have been reported with standard doxorubicin hydrochloride.
Croatian: U bolesnika s AIDS-om, pogoršanje hemoragijskog cistitisa izazvanog ciklofosfamidom i pojačanje hepatotoksičnosti 6-merkaptopurina zabilježeni su uz primjenu standardnog doksorubicinklorida.
English: Because doxorubicin hydrochloride may be harmful to nursing infants, women must discontinue breast-feeding before starting treatment with Caelyx.
Croatian: Budući da doksorubicinklorid može biti štetan za dojenu djecu, žene moraju prekinuti dojenje prije početka liječenja Caelyxom.
English: Grade 1 (mild erythema, swelling, or desquamation not interfering with daily activities)
Croatian: 1. stupanj (blagi eritem, oticanje ili ljuštenje koje ne ometa svakodnevne aktivnosti)
English: In a subset of 410 patients with ovarian cancer, clinically significant laboratory abnormalities occurring in clinical trials with Caelyx included increases in total bilirubin (usually in patients with liver metastases) (5%) and serum creatinine levels (5%).
Croatian: U podskupini od 410 bolesnica s karcinomom jajnika, klinički značajni laboratorijski poremećaji koji su se javili u kliničkim ispitivanjima lijeka Caelyx uključivali su povećanje ukupnog bilirubina (obično u bolesnica s metastazama u jetri) (5%) i razine kreatinina u serumu (5%).
English: 3 and/or the platelet count is < 50,000/mm
Croatian: 3 i/ili broj trombocita < 50.000/mm
English: The toxicity grading in these tables is based on the National Cancer Institute Common Toxicity Criteria (NCI-CTC).
Croatian: Stupnjevanje toksičnosti u tim tablicama temelji se na Općim kriterijima toksičnosti Nacionalnog instituta za rak (engl.
English: Aspartate aminotransferase increased, ejection fraction decreased, blood creatinine increased, alanine aminotransferase increased
Croatian: Često snižena tjelesna težina povišena aspartat aminotransferaza, smanjena ejekcijska frakcija, povišen kreatinin u krvi, povišena alanin aminotransferaza
English: Treatment will include administration of antibiotics, platelet cell transfusions, use of factors which stimulate production of white blood cells and symptomatic treatment of mouth sores.
Croatian: Liječenje će uključivati primjenu antibiotika, transfuziju krvnih pločica, primjenu čimbenika koji potiču proizvodnju bijelih krvnih stanica i simptomatsko liječenje ranica u ustima.
English: An increased incidence of congestive heart failure is associated with doxorubicin therapy at cumulative lifetime doses > 450 mg/m2 or at lower doses for patients with cardiac risk factors.
Croatian: Povećana incidencija kongestivnog zatajenja srca povezana je s liječenjem doksorubicinom u doživotnim kumulativnim dozama > 450 mg/m2 ili pri nižim dozama u bolesnika s rizičnim čimbenicima za srčanu bolest.
English: For common adverse events which required dose modification or discontinuation see section 4.8.
Croatian: Za česte nuspojave zbog kojih je potrebno prilagoditi dozu ili prekinuti primjenu, vidjeti dio 4.8.
English: Clinically significant laboratory abnormalities (grades 3 and 4) in this group was low with elevated total bilirubin, AST and ALT reported in 2.4%, 1.6% and < 1% of patients respectively.
Croatian: Učestalost klinički značajnih laboratorijskih poremećaja (stupanj 3 i 4) u ovoj skupini bila je niska, uz povišeni ukupni bilirubin uočen u 2,4%, AST u 1,6% i ALT u < 1% bolesnika.
English: In contrast, the pharmacokinetic profile of Caelyx indicates that Caelyx is confined mostly to the vascular fluid volume and that the clearance of doxorubicin from the blood is dependent upon the liposomal carrier.
Croatian: Nasuprot tomu, farmakokinetički profil Caelyxa pokazuje da je Caelyx uglavnom ograničen na vaskularni volumen tekućine i da klirens doksorubicina u krvi ovisi o liposomalnom nosaču.
English: 0.96-3.85 l/m2) approximating the plasma volume.
Croatian: 3,85 l/m 2) i približavao se vrijednosti plazmatskog volumena.
English: Breast cancer/Ovarian cancer/Multiple myeloma
Croatian: Karcinom dojke/karcinom jajnika/multipli mijelom
English: No grade 4 stomatitis was reported.
Croatian: Nije bio zabilježen niti jedan slučaj stomatitisa 4. stupnja.
English: Whenever cardiomyopathy is suspected, i.e., the left ventricular ejection fraction has substantially decreased relative to pre-treatment values and/or left ventricular ejection fraction is lower than a prognostically relevant value (e.g., < 45%), endomyocardial biopsy may be considered and the benefit of continued therapy must be carefully evaluated against the risk of developing irreversible cardiac damage.
Croatian: U slučaju sumnje na kardiomiopatiju, npr. kad je ejekcijska frakcija lijeve klijetke znatno smanjena u odnosu na vrijednosti prije liječenja i/ili je niža od prognostički važne vrijednosti (npr., < 45%), moguće je razmotriti biopsiju endomiokarda, a korist od nastavka liječenja mora se pažljivo procijeniti u odnosu na rizik od razvoja ireverzibilnog srčanog oštećenja.
English: Eye disorders common retinitis
Croatian: Poremećaji oka često retinitis
English: In patients with cardiac disease requiring treatment, administer Caelyx only when the benefit outweighs the risk to the patient.
Croatian: U bolesnika sa srčanom bolešću kojima je potrebno liječenje, primijenite Caelyx samo kada je korist od liječenja veća od rizika za bolesnika.
English: In most patients treatment can be resumed after all symptoms have resolved, without recurrence.
Croatian: U većine bolesnika liječenje se može nastaviti nakon što se svi simptomi povuku bez ponavljanja.
English: Section 4 of the package leaflet should be updated accordingly with the term “patches of skin thickening”.
Croatian: Dio 4. upute o lijeku treba ažurirati u skladu s izrazom "kožne promjene u obliku uzdignutih zadebljanja kože".
English: The total dose of doxorubicin hydrochloride must also take into account any previous (or concomitant) therapy with cardiotoxic compounds such as other anthracyclines/anthraquinones or e.g., 5-fluorouracil.
Croatian: Ukupna doza doksorubicinklorida uključuje i svako prethodno (ili istovremeno) liječenje kardiotoksičnim spojevima, kao što su drugi antraciklini/antrakinoni ili npr., 5-fluorouracil.
English: If no infusion reaction is observed, subsequent Caelyx infusions may be administered over a 60-minute period.
Croatian: Ako se ne primijeti nikakva reakcija na infuziju, daljnje infuzije Caelyxom mogu se primijeniti tijekom razdoblja od 60 minuta.
English: Redose unless patient has experienced a previous grade 3 or 4 skin toxicity, in which case wait an additional week
Croatian: Ponoviti dozu osim ako je bolesnik prethodno imao 3. ili 4. stupanj kožne toksičnosti, u tom slučaju potrebno je pričekati još jedan tjedan
English: In nearly all patients, Caelyx treatment can be resumed after all symptoms have resolved without recurrence.
Croatian: U gotovo svih bolesnika liječenje Caelyxom može se nastaviti nakon što se svi simptomi povuku, bez ponovne pojave.
English: Very rare side effects (may affect up to 1 in 10,000 people) - serious skin reactions such as widespread peeling skin, blisters as well as mucous membrane erosion (Stevens-Johnson syndrome/toxic epidermal necrolysis); - oral cancer may occur when Caelyx is taken for a long time (more than one year).
Croatian: Vrlo rijetke nuspojave (mogu se javiti u do 1 na 10 000 osoba) - ozbiljne kožne reakcije poput široko rasprostranjenog ljuštenja kože, mjehurića kao i erozija membrane sluznice (Stevens-Johnsonov sindrom/toksična epidermalna nekroliza); - rak u ustima može se javiti kada se Caelyx primjenjuje tijekom dužeg vremena (više od jedne godine).
English: No formal medicinal product interaction studies have been performed with Caelyx, although phase II combination trials with conventional chemotherapy agents have been conducted in patients with gynaecological malignancies.
Croatian: Nisu provedena formalna ispitivanja interakcija drugih lijekova s Caelyxom, iako su provedena kombinirana ispitivanja faze II s konvencionalnim kemoterapijskim sredstvima u bolesnica sa zloćudnim ginekološkim bolestima.
English: It is not known whether Caelyx is excreted in human milk.
Croatian: Nije poznato izlučuje li se Caelyx u majčino mlijeko.
English: The doxorubicin hydrochloride in Caelyx is enclosed in tiny spheres called pegylated liposomes which help to deliver the medicinal product from the blood stream to the cancerous tissue rather than healthy normal tissue.
Croatian: Doksorubicinklorid u Caelyxu smješten je unutar sitnih kuglica koje se zovu pegilirani liposomi i koje pomažu da lijek iz krvi uđe u tkivo raka, a ne u normalno zdravo tkivo.
English: Caelyx is also used to produce an improvement in your Kaposi's sarcoma including flattening, lightening and even shrinkage of the cancer.
Croatian: Caelyx se također primjenjuje za poboljšanje stanja kod Kaposijevog sarkoma gdje može izravnati, posvijetliti i čak smanjiti kancerozne promjene.
English: You should tell your doctor about any of the following: - if you are receiving any treatment for heart disease or liver disease; - if you are diabetic, because Caelyx contains sugar which may require an adjustment to the treatment of your diabetes; - if you have Kaposi's sarcoma and have had your spleen removed; - if you notice sores, discolouration or any discomfort in your mouth.
Croatian: Morate reći svom liječniku o sljedećem: - ako uzimate neki lijek zbog bolesti srca ili bolesti jetre; - ako imate šećernu bolest, zato što Caelyx sadrži šećer, zbog čega će Vam možda biti potrebno prilagoditi liječenje šećerne bolesti; - ako imate Kaposijev sarkom i uklonili su Vam slezenu;
English: Rare side effects (may affect up to 1 in 1,000 people) - blue colour to the skin and mucosa caused by low oxygen in the blood; - patches of skin thickening.
Croatian: Rijetke nuspojave (mogu se javiti u do 1 na 1000 osoba) - modra boja kože i sluznice uzrokovana niskom razinom kisika u krvi; - kožne promjene u obliku uzdignutih zadebljanja kože.
English: Skin and subcutaneous tissue disorders rare lichenoid keratosis very rare erythema multiforme, Stevens Johnson syndrome and toxic epidermal necrolysis
Croatian: Poremećaji kože i potkožnog tkiva rijetko lihenoidna keratoza vrlo rijetko multiformni eritem, Stevens-Johnsononov sindrom i toksična epidermalna nekroliza
English: Do not administer Caelyx as a bolus injection or undiluted solution.
Croatian: Nemojte primjenjivati Caelyx u obliku bolus injekcije ili nerazrijeđene otopine.
English: After dilution: - Chemical and physical in-use stability has been demonstrated for 24 hours at 2°C to 8°C.
Croatian: Nakon razrjeđivanja: - Dokazana kemijska i fizikalna stabilnost lijeka u primjeni je 24 sata na temperaturi od 2 °C do 8°C.
English: Determine the dose of Caelyx to be administered (based upon the recommended dose and the patient's body surface area).
Croatian: Odredite dozu Caelyxa koja će se primijeniti (na temelju preporučene doze i površine tijela bolesnika).
English: Very common side effects (may affect more than 1 in 10 people) - redness, swelling and sores on the palms of your hands and feet.
Croatian: Vrlo česte nuspojave (mogu se javiti u više od 1 na 10 osoba) - crvenilo, oticanje i ranice na dlanovima i tabanima.
English: This process is known as pegylation and protects liposomes from detection by the mononuclear phagocyte system (MPS), which increases blood circulation time.
Croatian: Taj se postupak naziva pegilacija i štiti liposome od mononuklearnog fagocitnog sustava, što produljuje vrijeme njihove cirkulacije u krvi.
English: Driving and using machines Do not drive or use any tools or machines if you feel tired or sleepy from treatment with Caelyx.
Croatian: Nemojte voziti ni koristiti alate ni strojeve ako zbog liječenja Caelyxom osjećate umor ili pospanost.
English: Caelyx is administered as an intravenous infusion.
Croatian: Caelyx se primjenjuje u obliku intravenske infuzije.
English: All Severities n=318
Croatian: Svi stupnjevi težine n=318
English: In addition, endomyocardial biopsies were performed in 8 solid tumour patients with cumulative anthracycline doses of 509 mg/m2-1,680 mg/m2.
Croatian: Dodatno su učinjene biopsije endomiokarda u 8 bolesnika sa solidnim tumorima koji su primili kumulativne doze antraciklina od 509 mg/m2 - 1,680 mg/m2.
English: If a test result indicates possible cardiac injury associated with Caelyx therapy, the benefit of continued therapy must be carefully weighed against the risk of myocardial injury.
Croatian: Ako rezultat neke pretrage pokaže moguće oštećenje srca povezano s liječenjem Caelyxom, potrebno je pažljivo procijeniti korist od nastavka liječenja u odnosu na rizik od oštećenja miokarda.
English: If any signs or symptoms of extravasation occur (e.g., stinging, erythema) terminate the infusion immediately and restart in another vein.
Croatian: Ako se pojave bilo kakvi znakovi ili simptomi ekstravazacije (npr. bockanje, eritem), odmah prekinite infuziju i nastavite s primjenom lijeka kroz drugu venu.
English: Growth factor support or transfusion support was necessary in 5.1% and 5.5% of patients, respectively (see section 4.2).
Croatian: Potpora čimbenikom rasta bila je neophodna u 5,1% bolesnika, a potpora transfuzijom za 5,5% (vidjeti dio 4.2).
English: Contains fully hydrogenated soy phosphatidylcholine (from soyabean) - see section 4.3 Contains less than 1 mmol sodium (23 mg) per dose, and is essentially ‘sodium-free'.
Croatian: Sadrži potpuno hidrogenirani sojin fosfatidilkolin (iz zrna soje) - vidjeti dio 4.3 Sadrži manje od 1 mmol (23 mg) natrija po dozi, tj. zanemarive količine natrija.
English: Week 6
Croatian: 6. tjedan
English: Recall of skin reaction due to prior radiotherapy has rarely occurred with Caelyx administration.
Croatian: Recidiv kožne reakcije zbog prethodne terapije zračenjem rijetko se javlja uz primjenu lijeka Caelyx.
English: Renal toxicity has been observed with even lower single doses of doxorubicin HCl in rats and rabbits.
Croatian: Bubrežna toksičnost uočena je čak i uz niže jednokratne doze doksorubicinklorida u štakora i kunića.
English: Population pharmacokinetic data (in the range of creatinine clearance tested of 30-156 ml/min) demonstrate that Caelyx clearance is not influenced by renal function.
Croatian: Podaci populacijske farmakokinetike (ispitane u rasponu klirensa kreatinina od 30 - 156 ml/min) pokazuju da funkcija bubrega ne utječe na klirens Caelyxa.
English: Grade 3 stomatitis was reported in 2% of patients in the combination therapy group.
Croatian: Stomatitis 3. stupnja zabilježen je u 2% bolesnika u skupini koja je primala kombiniranu terapiju.
English: Caelyx may be used as first-line systemic chemotherapy, or as second line chemotherapy in AIDS-KS patients with disease that has progressed with, or in patients intolerant to, prior combination systemic chemotherapy comprising at least two of the following agents: a vinca alkaloid, bleomycin and standard doxorubicin (or other anthracycline).
Croatian: Caelyx se može koristiti kao prva linija sistemske kemoterapije ili kao druga linija kemoterapije u bolesnika s Kaposijevim sarkomom povezanim s AIDS-om u kojih je bolest napredovala unatoč prethodnoj kombiniranoj sistemskoj kemoterapiji koja je uključivala najmanje dva od ovih lijekova: vinka alkaloid, bleomicin i standardni doksorubicin (ili drugi antraciklin), ili koji nisu podnosili tu terapiju.
English: The hypotensive response was reduced in magnitude by pretreatment with antihistamines.
Croatian: Premedikacija antihistaminicima smanjila je jačinu hipotenzivnog odgovora.
English: Caelyx contains soya oil.
Croatian: Caelyx sadrži sojino ulje.
English: Week 5
Croatian: 5. tjedan
English: In studies performed after the repeated administration of Caelyx to rats and dogs, serious dermal inflammations and ulcer formations were observed at clinically relevant dosages.
Croatian: U ispitivanjima provedenima nakon ponovljene primjene Caelyxa u štakora i pasa, ozbiljne kožne upale i stvaranje ulkusa opažene su uz klinički značajne doze.
English: Similar dermal lesions, which are described as palmar-plantar erythrodysesthesia were also observed in patients after long-term intravenous infusion (see section
Croatian: Slične lezije na koži, koje su opisane kao palmarno-plantarna eritrodizestezija, uočene su i u bolesnika nakon dugotrajne intravenske infuzije (vidjeti dio 4.8).
English: The tables for PPE (Table 1) and stomatitis (Table 2) provide the schedule followed for dose modification in clinical trials in the treatment of breast or ovarian cancer (modification of the recommended 4 week treatment cycle): if these toxicities occur in patients with AIDS-related KS, the recommended 2 to 3 week treatment cycle can be modified in a similar manner.
Croatian: U tablicama za PPE (tablica 1) i stomatitis (tablica 2) opisan je način prilagodbe doze primjenjen u kliničkim ispitivanjima liječenja karcinoma dojke ili jajnika (prilagodba preporučenog četverotjednog ciklusa liječenja): ako se takve toksičnosti pojave u bolesnika s Kaposijevim sarkomom povezanim s AIDS-om, preporučeni ciklus liječenja od 2 do 3 tjedna može se prilagoditi na sličan način.