FrancophonIA/ELRC3.0 huggingface dataset:
English: 117 / 276 patients from CD study I and 272 / 777 patients from CD studies II and III were followed through at least 3 years of open-label adalimumab therapy.
Croatian: Produljenje terapije na dulje od 12 tjedana ne daje bitno veći postotak odgovora (vidjeti dio 4.2). 117/276 bolesnika iz ispitivanja CD I i 272/777 bolesnika iz ispitivanja CD II i III praćeno je tijekom najmanje 3 godine otvorene terapije adalimumabom.
English: Halimatoz 40 mg solution for injection in single-use pre-filled SensoReady pen Halimatoz is supplied in a single-use pre-filled syringe assembled into a triangular-shaped pen with transparent window and label (SensoReady).
Croatian: Halimatoz 40 mg otopina za injekciju u napunjenoj SensoReady brizgalici za jednokratnu primjenu Halimatoz se isporučuje u napunjenoj štrcaljki za jednokratnu primjenu uloženoj u brizgalicu trokutastog oblika s prozirnim prozorčićem i naljepnicom (SensoReady brizgalica).
English: Antibiotics may be continued during treatment with Halimatoz if necessary.
Croatian: Ako je potrebno, primjena antibiotika može se nastaviti i tijekom liječenja lijekom Halimatoz.
English: Initial dose of 40 mg, followed by 40 mg given every other week starting one week after the initial dose
Croatian: 40 mg svaki drugi tjedan, počevši tjedan dana nakon početne doze
English: Patients should be tested for HBV infection before initiating treatment with Halimatoz.
Croatian: Bolesnike je potrebno prije početka terapije lijekom Halimatoz testirati na HBV infekciju.
English: • Halimatoz pre-filled syringe/s (see Figure A).
Croatian: • Halimatoz napunjena/e štrcaljka/e (vidjeti Sliku A).
English: Halimatoz is available as a pre-filled syringe and a pre-filled pen (SensoReady).
Croatian: Halimatoz može biti dostupan u obliku napunjene štrcaljke i napunjene brizgalice (SensoReady).
English: Keep this medicine out of the sight and reach of children.
Croatian: Kako čuvati lijek Halimatoz Lijek čuvajte izvan pogleda i dohvata djece.
English: Patients on Halimatoz may receive concurrent vaccinations, except for live vaccines.
Croatian: Bolesnici koji primaju lijek Halimatoz mogu istodobno primiti cjepiva, ali ne živa cjepiva.
English: For patients who develop the signs and symptoms such as fever, malaise, weight loss, sweats, cough, dyspnoea, and / or pulmonary infiltrates or other serious systemic illness with or without concomitant shock an invasive fungal infection should be suspected and administration of Halimatoz should be promptly discontinued.
Croatian: znojenje, kašalj, dispneja i/ili plućni infiltrati ili druge ozbiljne sistemske bolesti s istodobnim šokom ili bez njega, treba posumnjati na invazivnu gljivičnu infekciju te odmah prekinuti primjenu lijeka
English: • Halimatoz pre-filled SensoReady pen/s (see Figure A).
Croatian: • Napunjena/e brizgalica/e SensoReady s lijekom Halimatoz (vidjeti Sliku A).
English: Halimatoz is indicated for treatment of moderately to severely active ulcerative colitis in adult patients who have had an inadequate response to conventional therapy including corticosteroids and 6-mercaptopurine (6-MP) or azathioprine (AZA), or who are intolerant to or have medical contraindications for such therapies.
Croatian: Halimatoz je indiciran za liječenje umjerenog do teškog oblika aktivnog ulceroznog kolitisa u odraslih bolesnika u kojih nije postignut zadovoljavajući odgovor na konvencionalno liječenje, uključujući kortikosteroide i 6-merkaptopurin (6-MP) ili azatioprin (AZA), ili koji ne podnose ili kod kojih postoje medicinske kontraindikacije za takve terapije.
English: Halimatoz 40 mg / 0.8 ml injection adalimumab
Croatian: Halimatoz 40 mg / 0,8 ml injekcija adalimumab
English: The target of adalimumab is another protein called tumour necrosis factor (TNFα), which is present at increased levels in the inflammatory diseases listed above.
Croatian: Ciljna tvar za koju se vezuje adalimumab je protein pod nazivom faktor tumorske nekroze (TNFα),
English: • Do not give Halimatoz to children with polyarticular juvenile idiopathic arthritis below the age of
Croatian: • Nemojte davati Halimatoz djeci s poliartikularnim juvenilnim idiopatskim artritisom mlađoj od 2 godine.
English: PASI 75 and PGA clear or minimal increased with increasing adalimumab concentrations, both with a similar apparent EC50 of approximately 4.5 μg/mL (95% CI 0.4-47.6 and 1.9-10.5, respectively).
Croatian: u oba slučaja uz sličan prividan EC50 od približno 4,5 μg/ml (95% CI: 0,4-47,6 odnosno 1,9-10,5).
English: Children, adolescents and adults with enthesitis-related arthritis Children, adolescents and adults from 6 years of age weighing 30 kg or more The recommended dose of Halimatoz is 40 mg every other week.
Croatian: Djeca, adolescenti i odrasli s artritisom povezanim s entezitisom Djeca, adolescenti i odrasli u dobi od 6 i više godina, tjelesne težine 30 kg ili više Preporučena doza lijeka Halimatoz je 40 mg svaki drugi tjedan.
English: Halimatoz is indicated for the treatment of moderately to severely active Crohn's disease in paediatric patients (from 6 years of age) who have had an inadequate response to conventional therapy including primary nutrition therapy and a corticosteroid and / or an immunomodulator, or who are intolerant to or have contraindications for such therapies.
Croatian: Halimatoz je indiciran za liječenje umjerenog do teškog oblika aktivne Crohnove bolesti u pedijatrijskih bolesnika (u dobi od 6 godina i starijih) u kojih nije postignut zadovoljavajući odgovor na konvencionalnu terapiju, uključujući primarnu nutritivnu terapiju i liječenje kortikosteroidom i/ili imunomodulatorom ili u onih koji ne podnose ili u kojih su takve vrste terapija kontraindicirane.
English: Halimatoz can be taken together with methotrexate or certain disease-modifying anti-rheumatic agents (sulfasalazine, hydroxychloroquine, leflunomide and injectable gold preparations), corticosteroids or pain medications including non-steroidal anti-inflammatory drugs (NSAIDs).
Croatian: Halimatoz se može primjenjivati istodobno s metotreksatom ili nekim antireumaticima koji mijenjaju tijek bolesti (sulfasalazinom, hidroksiklorokinom, leflunomidom i injekcijskim pripravcima zlata),
English: A patient who requires surgery while on Halimatoz should be closely monitored for infections, and appropriate actions should be taken.
Croatian: Bolesnike kojima je za vrijeme liječenja lijekom Halimatoz potreban operativni zahvat potrebno je pomno pratiti zbog moguće pojave infekcija i poduzeti odgovarajuće mjere.
English: Multipack cartons contain 6 (3 packs of 2) pre-filled syringes of Halimatoz.
Croatian: Višestruka pakiranja sadrže 6 (3 pakiranja po 2) napunjenih štrcaljki lijeka Halimatoz.
English: EU/1/18/1288/004 1 pre-filled pen EU/1/18/1288/005 2 pre-filled pens
Croatian: EU/1/18/1288/004 1 napunjena brizgalica EU/1/18/1288/005 2 napunjene brizgalice
English: Treatment with Halimatoz may result in the formation of autoimmune antibodies.
Croatian: Za vrijeme primjene lijeka Halimatoz mogu se razviti autoimuna protutijela.
English: EU/1/18/1288/003 6 pre-filled syringes (3 packs of 2)
Croatian: EU/1/18/1288/003 6 napunjenih štrcaljki (3 pakiranja po 2)
English: The recommended dose of Halimatoz for patients with Crohn's disease from 6 to 17 years of age is based on body weight (table 4).
Croatian: Preporučena doza lijeka Halimatoz za bolesnike s Crohnovom bolešću u dobi od 6 do 17 godina određuje se na temelju tjelesne težine (tablica 4).
English: Halimatoz is indicated for the treatment of active enthesitis-related arthritis in patients, 6 years of age and older, who have had an inadequate response to, or who are intolerant of, conventional therapy (see section 5.1).
Croatian: Artritis povezan s entezitisom Halimatoz je indiciran za liječenje aktivnog artritisa povezanog s entezitisom u bolesnika u dobi od 6 godina i starijih u kojih nije postignut zadovoljavajući odgovor ili koji ne podnose konvencionalnu terapiju (vidjeti dio 5.1).
English: Patients must therefore be monitored closely for infections, including tuberculosis, before, during and after treatment with Halimatoz.
Croatian: Bolesnike se stoga mora pomno pratiti prije, za vrijeme i nakon završetka liječenja lijekom Halimatoz zbog moguće pojave infekcija, uključujući tuberkulozu.
English: Halimatoz is indicated for the treatment of adults with severe active ankylosing spondylitis who have had an inadequate response to conventional therapy.
Croatian: Halimatoz je indiciran za liječenje teškog oblika aktivnog ankilozantnog spondilitisa u odraslih osoba u kojih nije postignut zadovoljavajući odgovor na konvencionalno liječenje.
English: Halimatoz is used to treat rheumatoid arthritis in adults.
Croatian: Halimatoz je namijenjen liječenju reumatoidnog artritisa u odraslih.
English: EU/1/18/1288/001 1 pre-filled syringe EU/1/18/1288/002 2 pre-filled syringes
Croatian: EU/1/18/1288/001 1 napunjena štrcaljka EU/1/18/1288/002 2 napunjene štrcaljke
English: EU/1/18/1288/006 6 pre-filled pens (3 packs of 2)
Croatian: EU/1/18/1288/006 6 napunjenih brizgalica (3 pakiranja po 2)
English: Halimatoz 40 mg solution for injection in pre-filled syringe Halimatoz 40 mg solution for injection in pre-filled pen
Croatian: Halimatoz 40 mg otopina za injekciju u napunjenoj štrcaljki Halimatoz 40 mg otopina za injekciju u napunjenoj brizgalici
English: Halimatoz is injected under the skin (subcutaneous use).
Croatian: Halimatoz se ubrizgava pod kožu (supkutana primjena).
English: There is no relevant use of Halimatoz in children aged less than 2 years in this indication.
Croatian: Nema relevantne primjene lijeka Halimatoz u djece mlađe od 2 godine u ovoj indikaciji.
English: Your Halimatoz single-use pre-filled SensoReady pen
Croatian: Vaša jednokratna napunjena brizgalica SensoReady s lijekom Halimatoz
English: In non-infectious uveitis, corticosteroids or other medicines that influence the immune system may be continued while using Halimatoz.
Croatian: Kod nezaraznog uveitisa se uz lijek Halimatoz mogu nastaviti primjenjivati kortikosteroidi ili drugi lijekovi koji utječu na imunološki sustav.
English: Halimatoz is only available as 40 mg pre-filled syringe and 40 mg pre-filled pen.
Croatian: Halimatoz je dostupan samo kao napunjena štrcaljka od 40 mg i napunjena brizgalica od 40 mg.
English: Halimatoz should be used with caution in patients with mild heart failure (NYHA class I/II).
Croatian: . Zato se bolesnicima s blagim zatajenjem srca (NYHA razred I/II) Halimatoz mora davati oprezno.
English: The recommended Halimatoz dose for patients with plaque psoriasis from 4 to 17 years of age is based on body weight (table 3).
Croatian: Preporučena doza lijeka Halimatoz za bolesnike s plak psorijazom u dobi od 4 do 17 godina određuje se na temelju tjelesne težine (tablica 3).
English: Cartons contain 1 and 2 pre-filled syringes of Halimatoz.
Croatian: Kutije sadrže 1 ili 2 napunjene brizgalice lijeka Halimatoz.
English: Halimatoz dose for paediatric patients with plaque psoriasis Patient weight
Croatian: Tablica 3. Doza lijeka Halimatoz za pedijatrijske bolesnike s plak psorijazom
English: Halimatoz is administered by injection under the skin (by subcutaneous injection).
Croatian: Halimatoz se primjenjuje injekcijom pod kožu (supkutanom injekcijom).
English: All patients, and in particular patients with a medical history of extensive immunosuppressant therapy or psoriasis patients with a history of PUVA treatment should be examined for the presence of nonmelanoma skin cancer prior to and during treatment with Halimatoz.
Croatian: Sve bolesnike, a posebno one koji u anamnezi imaju dugotrajno korištenje imunosupresivne terapije ili bolesnike s psorijazom i PUVA liječenjem u anamnezi, potrebno je prije i za vrijeme liječenja lijekom
English: Thus, it is not possible to use Halimatoz for children who require less than a full 40 mg dose.
Croatian: Zato se Halimatoz ne može koristiti u djece koja zahtijeva manje od cijele doze od 40 mg.
English: The recommended dose of Halimatoz for patients with ankylosing spondylitis, axial spondyloarthritis without radiographic evidence of AS and for patients with psoriatic arthritis is 40 mg adalimumab administered every other week as a single dose via subcutaneous injection.
Croatian: aksijalnog spondiloartritisa bez radiografskog dokaza ankilozantnog spondilitisa te u bolesnika sa psorijatičnim artritisom iznosi 40 mg adalimumaba, a primjenjuje se kao pojedinačna doza svaka dva tjedna.
English: Multipack cartons contain 6 (3 packs of 2) pre-filled pens of Halimatoz.
Croatian: Višestruka pakiranja sadrže 6 (3 pakiranja po 2) napunjenih brizgalica lijeka Halimatoz.
English: Halimatoz dose for patients with enthesitis-related arthritis Patient weight
Croatian: Tablica 2. Doza lijeka Halimatoz za bolesnike s artritisom povezanim s entezitisom
English: Halimatoz is indicated for the treatment of paediatric chronic non-infectious anterior uveitis in patients from 2 years of age who have had an inadequate response to or are intolerant to conventional therapy, or in whom conventional therapy is inappropriate.
Croatian: Uveitis u djece Halimatoz je indiciran za liječenje kroničnog neinfektivnog anteriornog uveitisa u djece u dobi od 2 godine i starije u koje nije postignut zadovoljavajući odgovor na konvencionalno liječenje, koji ne podnose konvencionalno liječenje ili u kojih konvencionalno liječenje nije prikladno.
English: Halimatoz is used to treat ulcerative colitis in adults.
Croatian: Halimatoz je namijenjen liječenju ulceroznog kolitisa u odraslih.
English: If you do not respond well enough to these medicines, you will be given Halimatoz to reduce the signs and symptoms of your Crohn's disease.
Croatian: Ako ti lijekovi ne djeluju dovoljno dobro, u svrhu smanjenja znakova i simptoma Crohnove bolesti bit će Vam propisan lijek
English: Be sure that you read, understand, and follow these Instructions for Use before injecting Halimatoz.
Croatian: Prije ubrizgavanja lijeka Halimatoz morate pročitati, razumjeti i pridržavati se ovih Uputa za uporabu.
English: Glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs, or analgesics can be continued during treatment with Halimatoz.
Croatian: Za vrijeme liječenja lijekom Halimatoz može se nastaviti s davanjem glukokortikoida, salicilata, nesteroidnih protuupalnih lijekova ili analgetika.
English: Package leaflet: Information for the patient Halimatoz 40 mg solution for injection in pre-filled pen adalimumab
Croatian: Uputa o lijeku: Informacije za bolesnika Halimatoz 40 mg otopina za injekciju u napunjenoj brizgalici adalimumab
English: Halimatoz is indicated for treatment of moderately to severely active Crohn's disease in adult patients who have not responded despite a full and adequate course of therapy with a corticosteroid and / or an immunosuppressant; or who are intolerant to or have medical contraindications for such therapies.
Croatian: Halimatoz je indiciran za liječenje umjerenog do teškog oblika aktivne Crohnove bolesti u odraslih bolesnika u kojih unatoč prethodnom potpunom i odgovarajućem tijeku liječenja kortikosteroidima i/ili imunosupresivima nije postignut odgovor ili kod bolesnika koji ih ne podnose ili im je takva terapija kontraindicirana.
English: There is little experience from re-administration after more than 8 weeks since the previous dose.
Croatian: Postoji malo podataka o ponovnoj primjeni lijeka Halimatoz kad je prekid terapije trajao duže od 8 tjedana.
English: In adolescent patients with inadequate response to Halimatoz 40 mg every other week, an increase in dosage to 40 mg every week or 80 mg every other week may be considered.
Croatian: U adolescentnih bolesnika u kojih nije postignut zadovoljavajući odgovor na lijek Halimatoz u dozi od 40 mg svaki drugi tjedan može se razmotriti povećanje doziranja na 40 mg svaki tjedan ili 80 mg svaki drugi tjedan.
English: Halimatoz 40 mg solution for injection (injection) in pre-filled syringe is supplied as a 0.8 ml clear to slightly opalescent, colourless to slightly yellowish solution.
Croatian: Halimatoz 40 mg otopina za injekciju (injekcija) u napunjenoj brizgalici isporučuje se kao 0,8 ml bistre do blago opalescentne, bezbojne do blago žućkaste otopine.
English: Halimatoz is used to treat psoriatic arthritis in adults.
Croatian: Halimatoz je namijenjena liječenju psorijatičnog artritisa u odraslih.
English: The recommended dose of Halimatoz for patients with enthesitis-related arthritis from 6 years of age is based on body weight (table 2).
Croatian: Preporučena doza lijeka Halimatoz za bolesnike s artritisom povezanim s entezitisom u dobi od 6 i više godina određuje se na temelju tjelesne težine (tablica 2).
English: If these medicines do not work well enough, you will be given Halimatoz to reduce the signs and symptoms of your disease.
Croatian: Vam propisan lijek Halimatoz kako bi se smanjili simptomi i znakovi Vaše bolesti.
English: Thus, it is not possible to administer Halimatoz to paediatric patients that require less than a full 40 mg dose.
Croatian: Zato se Halimatoz ne može primijeniti u pedijatrijskih bolesnika koji zahtijevaju manje od cijele doze od 40 mg.
English: Halimatoz can also be used to treat severe, active and progressive rheumatoid arthritis without previous methotrexate treatment.
Croatian: U svrhu liječenja teškog, aktivnog i progresivnog reumatoidnog artritisa, Halimatoz se može primijeniti i bez prethodnog liječenja metotreksatom.
English: In patients who develop HBV reactivation, Halimatoz should be stopped and effective anti-viral therapy with appropriate supportive treatment should be initiated.
Croatian: Halimatoz i započeti učinkovita antivirusna terapija uz odgovarajuće potporne mjere.
English: The recommended dose of Halimatoz for patients with polyarticular juvenile idiopathic arthritis from 2 years of age is based on body weight (table 1).
Croatian: Poliartikularni juvenilni idiopatski artritis u dobi od 2 i više godina Preporučena doza lijeka Halimatoz za bolesnike s poliartikularnim juvenilnim idiopatskim artritisom u dobi od 2 i više godina određuje se na temelju tjelesne težine (tablica 1).
English: Each pen contains 40 mg/0.8 ml of
Croatian: Jedna štrcaljka sadrži 40 mg/0,8 ml lijeka
English: Halimatoz is only available as 40 mg pre-filled syringe / pre-filled pen.
Croatian: Halimatoz je dostupan samo kao napunjena štrcaljka od 40 mg/napunjena brizgalica od 40 mg.
English: Halimatoz 40 mg solution for injection in pre-filled syringe adalimumab
Croatian: Halimatoz 40 mg otopina za injekciju u napunjenoj štrcaljki adalimumab
English: The recommended dose of Halimatoz for adult patients with rheumatoid arthritis is 40 mg adalimumab administered every other week as a single dose via subcutaneous injection.
Croatian: U odraslih bolesnika s reumatoidnim artritisom preporučena doza lijeka Halimatoz iznosi 40 mg, a daje se kao jednokratna doza svaka dva tjedna supkutanom injekcijom.
English: The recommended Halimatoz dose is 80 mg at week 0 followed by 40 mg every other week starting at week 1 via subcutaneous injection.
Croatian: Preporučena doza lijeka Halimatoz je 80 mg u nultom tjednu, nakon koje se primjenjuje doza od 40 mg svaki drugi tjedan, počevši od prvog tjedna, supkutanom injekcijom.
English: Halimatoz is used to treat moderate to severe plaque psoriasis in adults.
Croatian: Halimatoz je namijenjena liječenju umjerene do teške plak psorijaze u odraslih.
English: Halimatoz 40 mg injection adalimumab
Croatian: Halimatoz 40 mg injekcija adalimumab s.c.
English: Halimatoz 40 mg solution for injection in pre-filled syringe:
Croatian: Halimatoz 40 mg otopina za injekciju u napunjenoj štrcaljki:
English: Halimatoz therapy should not be continued in patients failing to respond within this time period.
Croatian: bolesnika u kojih u ovom razdoblju ne bude odgovora, liječenje lijekom Halimatoz ne treba nastaviti.
English: The recommended dose of Halimatoz is an initial dose of 80 mg (as two 40 mg injections in one day), followed by 40 mg every other week starting one week later.
Croatian: Preporučeno doziranje lijeka Halimatoz je početna doza od 80 mg (u obliku dvije injekcije od 40 mg u jednom danu), a zatim 40 mg svaka dva tjedna, počevši tjedan dana kasnije.
English: Halimatoz is used in adults to treat these conditions.
Croatian: Halimatoz je namijenjen liječenju tih bolesti u odraslih.
English: Thus, it is not possible to administer Halimatoz to patients that require less than a full 40 mg dose.
Croatian: Zato se Halimatoz ne može primijeniti u bolesnika koji zahtijevaju manje od cijele doze od 40 mg.
English: How to store Halimatoz
Croatian: Kako primjenjivati lijek Halimatoz
English: Patients should be instructed to seek medical advice if signs / symptoms suggestive of a tuberculosis infection (e.g., persistent cough, wasting/weight loss, low grade fever, listlessness) occur during or after therapy with Halimatoz.
Croatian: Bolesnike se mora upozoriti da se obrate liječniku ako se za vrijeme ili nakon liječenja lijekom Halimatoz pojave znakovi/simptomi koji upućuju na tuberkuloznu infekciju (npr. perzistirajući kašalj,
English: Some patients who experience decrease in their response to Halimatoz 40 mg every other week may benefit from an increase in dosage to 40 mg Halimatoz every week or 80 mg every other week.
Croatian: U nekih bolesnika u kojih dođe do slabljenja odgovora na terapiju Halimatozom u dozi od 40 mg svaki drugi tjedan možda će biti korisno povećati doziranje na 40 mg lijeka Halimatoz svaki tjedan ili 80 mg svaki drugi tjedan.
English: Coagulation and bleeding disorders (including activated partial thromboplastin time prolonged), autoantibody test positive (including double stranded DNA antibody), blood lactate dehydrogenase increased
Croatian: Poremećaji koagulacije i krvarenja (uključujući produljenje aktiviranog parcijalnog tromboplastinskog vremena),
English: The recommended dose of Halimatoz for paediatric patients with uveitis from 2 years of age is based on body weight (table 5).
Croatian: Preporučena doza lijeka Halimatoz za pedijatrijske bolesnike s uveitisom u dobi od 2 i više godina određuje se na temelju tjelesne težine (tablica 5).
English: The recommended dose of Halimatoz for adult patients with uveitis is an initial dose of 80 mg, followed by 40 mg given every other week starting one week after the initial dose.
Croatian: Preporučena doza lijeka Halimatoz u odraslih bolesnika s uveitisom je početna doza od 80 mg, nakon koje slijedi doza od 40 mg svaki drugi tjedan, počevši tjedan dana nakon početne doze.
English: The recommended Halimatoz dose regimen for adult patients with hidradenitis suppurativa (HS) is 160 mg initially at Day 1 (given as four 40 mg injections in one day or as two 40 mg injections per day for two consecutive days), followed by 80 mg two weeks later at Day 15 (given as two 40 mg injections in one day).
Croatian: Preporučen režim doziranja lijeka Halimatoz za odrasle bolesnike s gnojnim hidradenitisom je početna doza od 160 mg prvoga dana (primijenjena u obliku četiri injekcije od 40 mg u jednom danu ili dvije injekcije od 40 mg na dan tijekom dva uzastopna dana), nakon koje slijedi doza od 80 mg dva tjedna kasnije, 15. dana (primijenjena u obliku dvije injekcije od 40 mg u jednom danu).
English: The recommended Halimatoz induction dose regimen for adult patients with moderate to severe ulcerative colitis is 160 mg at week 0 (given as four 40 mg injections in one day or as two 40 mg injections per day for two consecutive days) and 80 mg at week 2 (given as two 40 mg injections in one day).
Croatian: Preporučena indukcijska doza lijeka Halimatoz u odraslih bolesnika s umjerenim do teškim ulceroznim kolitisom je 160 mg u nultom tjednu (primijenjena u obliku četiri injekcije od 40 mg u jednom danu ili kao dvije injekcije od 40 mg na dan kroz dva uzastopna dana) i 80 mg u drugom tjednu (primijenjena u obliku dvije injekcije od 40 mg u jednom danu).