FrancophonIA/ELRC3.0 huggingface dataset:
English: In an additional active-controlled clinical study in 1,169 adult patients receiving aprepitant and HEC, the adverse reactions profile was generally similar to that seen in the other HEC studies with aprepitant.
Danish: I et supplerende aktivt kontrolleret klinisk studie med 1.169 voksne patienter, der fik aprepitant og HEC, var bivirkningsprofilen generelt den samme som i andre HEC-studier med aprepitant.
English: Stop taking EMEND and see a doctor immediately if you or the child notice any of the following side effects, which may be serious, and for which you or the child may need urgent medical treatment: - Hives, rash, itching, difficulty breathing or swallowing (frequency not known, cannot be estimated from the available data); these are signs of an allergic reaction.
Danish: Stop med at tage EMEND og kontakt straks lægen, hvis du eller barnet bemærker en eller flere af følgende bivirkninger, som kan være alvorlige, og for hvilke akut lægebehandling kan være nødvendig: - Nældefeber, udslæt, kløe, vejrtræknings- eller synkebesvær (hyppigheden er ikke kendt, kan ikke vurderes ud fra tilgængelige data); disse symptomer er tegn på en allergisk reaktion.
English: Lactose (anhydrous) Red iron oxide (E 172) Sodium stearyl fumarate (E 485)
Danish: Lactose (vandfrit) Rødt jernoxid (E172) Natriumstearylfumarat (E485)
English: There are some medicines that should not be taken with EMEND (such as pimozide, terfenadine, astemizole, and cisapride) or that require a dose adjustment (see also Do not take EMEND).
Danish: Der er visse lægemidler, der ikke må tages sammen med EMEND (såsom pimozid, terfenadin, astemizol og cisaprid), eller som kræver justering af dosis (se også Tag ikke EMEND).
English: Please talk to the doctor or pharmacist if you or the child is taking any of the following medicines:
Danish: Tal med lægen eller apotekspersonalet, hvis du eller barnet tager et eller flere af følgende lægemidler:
English: Administration of body surface area adjusted doses to patients 6 months to less than 12 years achieved a mean AUC0-48hr above 4 µg/mL with a mean Cmax above 0.5 µg/mL occurring at approximately 3 hours.
Danish: Administration af doser justeret efter legemsoverflade til patienter i alderen 6 måneder til under 12 år opnåede et gennemsnitligt AUC0-48t over 4 µg/ml med en gennemsnitlig Cmax over 0,5 µg/ml, der forekom efter cirka 3 timer.
English: Always take this medicine or give this medicine to the child exactly as the doctor, pharmacist or nurse has told you.
Danish: Tag altid lægemidlet eller giv lægemidlet til barnet nøjagtigt efter lægens, apotekspersonalets eller sundhedspersonalets anvisning.
English: Paediatric population: In a study using a powder for oral suspension formulation, a single dose of 40 mg aprepitant administered to adolescent patients (aged 12 through 17 years) resulted in a mean AUC0-48hr of 6 µg/mL with a mean peak plasma concentration (Cmax) of 0.5 µg/mL occurring at approximately 4 hours.
Danish: Pædiatrisk population: I et studie med et pulver til oral suspension resulterede en enkeltdosis af 40 mg aprepitant administreret til unge patienter (i alderen 12 -17 år) i et gennemsnitligt AUC0-48t på 6 µg/ml med en gennemsnitlig peakplasmakoncentration (Cmax) på 0,5 µg/ml, og forekom efter cirka 4 timer.
English: Stop taking EMEND and see a doctor immediately if you notice any of the following side effects, which may be serious, and for which you may need urgent medical treatment: - Hives, rash, itching, difficulty breathing or swallowing (frequency not known, cannot be estimated from the available data); these are signs of an allergic reaction.
Danish: Stop med at tage EMEND og kontakt straks lægen, hvis du bemærker en eller flere af følgende bivirkninger, som kan være alvorlige, og for hvilke akut lægebehandling kan være nødvendig: - Nældefeber, udslæt, kløe, vejrtræknings- eller synkebesvær (hyppigheden er ikke kendt, kan ikke vurderes ud fra tilgængelige data); disse symptomer er tegn på en allergisk reaktion.
English: After reconstitution: The oral suspension can be kept at room temperature (not above 30°C) for up to 3 hours.
Danish: Efter rekonstitution: Den orale suspension kan opbevares ved almindelig temperatur (højst 30 °C) i op til 3 timer.
English: Do not take EMEND: - if you or the child is allergic to aprepitant or any of the other ingredients of this medicine (listed in section 6).
Danish: Tag ikke EMEND: - hvis du eller barnet er allergisk over for aprepitant eller et af de øvrige indholdsstoffer i EMEND (angivet i punkt 6).
English: 80 mg orally
Danish: 80 mg oralt
English: As part of a 3-day regimen, dosing of aprepitant powder for oral suspension (3/2/2-mg/kg) in patients aged 6 months to less than12 years achieved an AUC0-24hr above 17 µg•hr/mL on Day 1 with concentrations (Cmin) at the end of Days 2 and 3 above 0.1 µg/mL in a majority of patients.
Danish: Som en del af et 3-dags regime resulterede dosering af aprepitant pulver til oral suspension (3/2/2-mg/kg) hos patienter i alderen 6 måneder til under 12 år i et AUC0-24t på over 17 µg•t/ml på dag 1 med koncentrationer (Cmin) ved afslutningen af dag 2 og 3 på over 0,1 µg/ml hos størstedelen af patienterne.
English: Do not give this medicine to the child after the expiry date which is stated on the carton and sachet after EXP.
Danish: Giv ikke dette lægemiddel til barnet efter den udløbsdato, der står på kartonen og folieposen efter EXP. Udløbsdatoen er den sidste dag i den nævnte måned.
English: This increase is not considered clinically relevant.
Danish: Denne stigning ansås ikke for at være klinisk relevant.
English: EMEND increased the AUC of midazolam, a sensitive CYP3A4 substrate, 2.3-fold on Day 1 and 3.3-fold on Day 5, when a single oral dose of 2 mg midazolam was co-administered on Days 1 and 5 of a regimen of EMEND 125 mg on Day 1 and 80 mg/day on Days 2 to 5.
Danish: EMEND forhøjede AUC for midazolam, et følsomt CYP3A4-substrat, 2,3 gange på dag 1 og 3,3 gange på dag 5, når en oral enkeltdosis midazolam 2 mg administreredes samtidig på dag 1 og dag 5 med et EMEND behandlingsregime på 125 mg på dag 1 og 80 mg/dag på dag 2-5.
English: 125 mg orally
Danish: 125 mg oralt
English: 3-day treatment pack containing: 1 x 125 mg hard capsule and 2 x 80 mg hard capsule
Danish: 3-dages behandlingspakning indeholdende: 1 x 125 mg hård kapsel og 2 x 80 mg hårde kapsler
English: Check the EMEND mixture for any clumps or foaming: - If any clumps are present, repeat Step 7 until there are no clumps.
Danish: - Hvis der er klumper i blandingen, skal du gentage trin 7, indtil der ikke er flere klumper.
English: Co-administration with warfarin (a CYP2C9 substrate) In patients on chronic warfarin therapy, the International Normalised Ratio (INR) should be monitored closely during treatment with EMEND and for 14 days following each 3-day course of EMEND (see section 4.5).
Danish: Samtidig administration med warfarin (et CYP2C9-substrat) Hos patienter i kronisk warfarinbehandling bør International Normaliseret Ratio (INR) overvåges nøje under behandling med EMEND og i 14 dage efter hvert 3-dages behandlingsregime med EMEND (se pkt.
English: In the same clinical study, 744 adult patients continued into the Multiple-Cycle extension for up to 3 additional cycles of chemotherapy.
Danish: I samme kliniske undersøgelse fortsatte 744 voksne patienter i gentagne kemoterapibehandlinger (multi-cyklus) og op til 3 yderligere kemoterapibehandlinger.
English: 2-day treatment pack containing: 2 x 80 mg hard capsule 5 x 1 hard capsule
Danish: 2-dages behandlingspakke indeholdende: 2 x 80 mg hårde kapsler 5 x 1 hård kapsel
English: For information regarding birth control, see ‘Other medicines and EMEND'.
Danish: For oplysninger angående prævention, se "Brug af anden medicin sammen med EMEND".
English: Aprepitant Regimen (N=520) Standard Therapy (N=523)
Danish: Aprepitant regime (N=520) Standard behandling (N=523)
English: Paediatric population: As part of a 3-day regimen, dosing of aprepitant capsules (125/80/80-mg) in adolescent patients (aged 12 through 17 years) achieved an AUC0-24hr above 17 µg•hr/mL on Day 1 with concentrations (Cmin) at the end of Days 2 and 3 above 0.4 µg/mL in a majority of patients.
Danish: Pædiatrisk population: Som en del af et 3-dags regime resulterede dosering af aprepitant-kapsler (125/80/80-mg) hos unge patienter (i alderen 12 til 17 år) i et AUC0-24t på over 17 µg•t/ml på dag 1 med koncentrationer (Cmin) ved afslutningen af dag 2 og 3 på over 0,4 µg/ml hos størstedelen af patienterne.
English: Studies evaluating the use of aprepitant in paediatric patients are on-going (see section 4.2 for information on paediatric use).
Danish: Studier til vurdering af anvendelse af aprepitant hos pædiatriske patienter er igangværende (se pkt.
English: Aprepitant is a substrate, a moderate inhibitor, and an inducer of CYP3A4.
Danish: Aprepitant er et substrat, en moderat hæmmer samt inducer af CYP3A4.
English: Potassium hydroxide Black iron oxide (E 172)
Danish: Kaliumhydroxid Sort jernoxid (E172)
English: Titanium dioxide (E 171) Indigo carmine (E 132)
Danish: Titandioxid (E171) Indigocarmin (E132)
English: OUTER PACKAGING - TRIFOLD PACK (CARTON) - 3-day treatment pack
Danish: YDRE EMBALLAGE - TRIPPELPAKNING (KARTON) - pakning til 3 dages behandling
English: Methylprednisolone: The usual intravenously administered methylprednisolone dose should be reduced approximately 25 %, and the usual oral methylprednisolone dose should be reduced approximately 50 % when co-administered with EMEND 125 mg/80 mg regimen.
Danish: Methylprednisolon: Den normale intravenøse methylprednisolondosis bør reduceres med ca. 25 %, og den normale orale methylprednisolondosis bør reduceres med ca. 50 %, når de administreres samtidig med EMEND 125 mg/80 mg dosisregime.
English: The adverse reactions profiles in adults in the Multiple-Cycle extension of HEC and MEC studies for up to 6 additional cycles of chemotherapy were generally similar to those observed in Cycle 1.
Danish: Bivirkningsprofilen hos voksne i gentagne kemoterapibehandlinger (multi-cyklus) i HEC- og MECstudierne i op til 6 efterfølgende kemoterapicykler var generelt de samme, som sås i første cyklus.
English: Methylprednisolone: Interaction studies with aprepitant 165 mg and methylprednisolone have not been conducted; however, the following study with the aprepitant 125 mg/80 mg regimen should be considered when using EMEND 165 mg with methylprednisolone.
Danish: Methylprednisolon: Der er ikke udført interaktionsstudier med aprepitant 165 mg og methylprednisolon; følgende studie med et aprepitantregime på 125 mg/80 mg bør dog overvejes ved anvendelse af EMEND 165 mg sammen med methylprednisolon.
English: EMEND capsules can be taken with or without food.
Danish: EMEND kapsler kan indtages med eller uden mad.
English: Following oral administration of a single 125 mg dose of EMEND on Day 1 and 80 mg once daily on Days 2 and 3, the AUC0-24hr (mean±SD) was 19.6 ± 2.5 µg•h/mL and 21.2 ± 6.3 µg •h/mL on Days 1 and 3, respectively.
Danish: Efter oral administration af en enkelt 125 mg dosis af EMEND på dag 1 og 80 mg én gang dagligt på dag 2 og 3 var AUC0-24 timer (middel SD) henholdsvis 19,62,5 µg∙t/ml på dag 1 og 21,26,3 µg∙t/ml på dag 3.
English: oC and 8
Danish: oC) i op til 3
English: EMEND 125 mg capsule
Danish: EMEND 125 mg kapsel.
English: The powder for oral suspension is used in children aged 6 months to less than 12 years in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (cancer treatment) that are strong and moderate triggers of nausea and vomiting (such as cisplatin, cyclophosphamide, doxorubicin or epirubicin).
Danish: Pulver til oral suspension anvendes hos børn i alderen 6 måneder til under 12 år i kombination med anden medicin til at forebygge kvalme og opkastning i forbindelse med kemoterapibehandling (behandling af kræft), der er kraftige og moderate udløsere af kvalme og opkastning (fx cisplatin, cyclophosphamid, doxorubicin eller epirubicin).
English: The dose of dexamethasone in chemotherapy induced nausea and vomiting clinical trials was chosen to account for active substance interactions (see section 4.2).
Danish: Dexamethasondosis blev i kliniske undersøgelser for kvalme og opkastning forårsaget af kemoterapi valgt for at tage højde for lægemiddelinteraktioner (se pkt.
English: What you need to know before you give EMEND
Danish: Det skal du vide, før du begynder at give EMEND
English: - birth control medicines which can include birth control pills, skin patches, implants, and certain Intrauterine devices (IUDs) that release hormones may not work adequately when taken together with EMEND.
Danish: - Hormonholdige lægemidler til forebyggelse af graviditet som fx p-piller, plastre, implantater og visse former for hormonspiral virker måske ikke tilstrækkeligt, når de tages sammen med
English: Place the cap on the oral dispenser until it clicks.
Danish: 10. Sæt hætten på dispenseringssprøjten, indtil den klikker på plads.
English: In an additional active-controlled clinical study in 1,169 adult patients receiving the 3-day oral aprepitant regimen and HEC, the adverse reactions profile was generally similar to that seen in the other HEC studies with the 3-day oral aprepitant regimen.
Danish: I et supplerende aktivt-kontrolleret klinisk studie hos 1.169 voksne patienter, der fik 3-dages oralt aprepitantregime og HEC, var bivirkningsprofilen generelt den samme, som sås i de andre HECstudier med 3-dages oralt aprepitantregime.
English: Dexamethasone: Interaction studies with aprepitant 165 mg and dexamethasone have not been conducted; however, the following study with 200 mg of aprepitant should be considered when using EMEND 165 mg with oral dexamethasone.
Danish: Dexamethason: Der er ikke udført interaktionsstudier med aprepitant 165 mg og dexamethason; følgende studie med 200 mg aprepitant bør dog overvejes ved anvendelse af EMEND 165 mg sammen med oral dexamethason.
English: EMEND (40 mg) should be used with caution in patients receiving concomitant administration of pimozide, terfenadine, astemizole, cisapride or ergot alkaloid derivatives.
Danish: EMEND (40 mg) bør anvendes med forsigtighed til patienter, der samtidigt får pimozid, terfenadin, astemizol, cisaprid eller sekalealkaloidderivater.
English: If you give the child more than you should, contact the doctor straight away.
Danish: Hvis du har givet barnet for meget af lægemidlet, skal du straks kontakte lægen.
English: *Nausea and vomiting were efficacy parameters in the first 5 days of post-chemotherapy treatment and were reported as reactions only thereafter.
Danish: *Kvalme og opkastning var effektparametre de første 5 dage efter kemoterapibehandling og først derefter indberettet som bivirkninger.
English: Complete response (no emesis and no rescue therapy) Overall (0-120 hours)
Danish: Komplet Respons (ingen opkastning og ingen erstatningsterapi) Totalt (0-120 timer)
English: Intravenous 2 mg midazolam was given 1 hour after oral administration of a single dose of EMEND 125 mg.
Danish: Intravenøs midazolam 2 mg blev givet 1 time efter oral administration af en enkelt dosis EMEND 125 mg. Plasma AUC for midazolam øgedes 1,5 gange.
English: The AUC of orally administrated midazolam increased by 1.2-fold when a single dose of 40 mg aprepitant was co-administered with a single oral dose of 2 mg midazolam; this effect was not considered clinically important.
Danish: Ved samtidig administration af en enkelt dosis aprepitant 40 mg og en enkelt oral dosis midazolam 2 mg øgedes AUC for oralt administreret midazolam 1,2 gange; denne effekt blev ikke anset for at være klinisk signifikant.
English: The aprepitant regimen for adolescents aged 12 through 17 years (n=47) consisted of EMEND capsules 125 mg orally on Day 1 and 80 mg/day on Days 2 and 3 in combination with ondansetron on Day 1.
Danish: Aprepitantregimet for unge i alderen 12 til 17 år (n=47) bestod af EMEND kapsler 125 mg oralt på dag 1 og 80 mg/dag på dag 2 og 3 i kombination med ondansetron på dag 1.
English: Using a highly specific NK1-receptor tracer, positron emission tomography (PET) studies in healthy young men have shown that aprepitant penetrates into the brain and occupies NK1 receptors in a doseand plasma-concentration-dependent manner.
Danish: Ved brug af en høj-specifik NK1-receptortracer har positron emissionstomografi (PET) undersøgelser i raske unge mænd vist, at aprepitant penetrerer hjernebarrieren og sætter sig på NK1-receptorer på en dosis- og plasmakoncentrationsafhængig måde.
English: After treatment with EMEND, the doctor may ask the child to continue taking other medicines for preventing nausea and vomiting which may include: - a corticosteroid - such as dexamethasone and - a ‘5-HT3 antagonist' - such as ondansetron Check with the doctor, pharmacist or nurse if you are not sure.
Danish: Efter behandlingen med EMEND kan lægen bede barnet fortsætte med at tage anden medicin til forebyggelse af kvalme og opkastning, som kan omfatte: - et kortikosteroid - såsom dexamethason og - en ”5-HT3 antagonist” - såsom ondansetron.
English: EMEND contains sucrose and lactose
Danish: EMEND indeholder saccharose og lactose
English: Renal impairment: A single 240 mg dose of aprepitant was administered to patients with severe renal impairment (CrCl < 30 mL/min) and to patients with end stage renal disease (ESRD) requiring haemodialysis.
Danish: Nedsat nyrefunktion: En enkelt 240 mg dosis aprepitant blev administreret til patienter med svært nedsat nyrefunktion (CrCl< 30 ml/min) og til hæmodialysepatienter i det sene stadie (end stage) af nyresygdom.
English: No dose adjustment is necessary for patients with renal impairment or for patients with end stage renal disease undergoing haemodialysis (see section 5.2).
Danish: Dosisjustering er ikke nødvendig hos patienter med nedsat nyrefunktion eller til hæmodialysepatienter i det sene stadie (end stage) af nyresygdom (se pkt.5.2).
English: Aprepitant regimen (N= 433)
Danish: Aprepitant behandlingsregime (N=433)
English: There are limited data in patients with moderate hepatic impairment and no data in patients with severe hepatic impairment.
Danish: Der foreligger begrænsede data for patienter med moderat nedsat leverfunktion og ingen data for patienter med svært nedsat leverfunktion.
English: Tell the doctor before treatment with EMEND starts, if the child has liver problems.
Danish: Før behandlingen med EMEND påbegyndes skal du fortælle lægen, hvis barnet har leverproblemer.
English: Aprepitant is a substrate, and a dose-dependent inhibitor, and an inducer of CYP3A4.
Danish: Aprepitant er et substrat og en dosiafhængig hæmmer og inducer af CYP3A4.
English: Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy in adults.
Danish: Forebyggelse af kvalme og opkastning i forbindelse med moderat emetogen cancerkemoterapi hos voksne.
English: No dose adjustment is necessary for patients with mild hepatic impairment.
Danish: Dosisjustering er ikke nødvendig hos patienter med mild nedsat leverfunktion.
English: For CYP2C9 and CYP3A4 substrates the induction is transient with a maximum effect reached after 3-5 days.
Danish: For CYP2C9- og CYP3A4-substraterne er induktionen forbigående med maksimal effekt efter 3-5 dage.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING (INCLUDING 1 HARD CAPSULE 125 MG AND 2 HARD CAPUSULES 80 MG)
Danish: MÆRKNING, DER SKAL ANFØRES PÅ DEN INDRE EMBALLAGE (INDEHOLDENDE 1 HÅRD KAPSEL 125 MG OG 2 HÅRDE KAPSLER 80 MG)
English: Aprepitant plasma concentrations achieved with the 3-day regimen of EMEND in adults are predicted to provide greater than 95 % occupancy of brain NK1 receptors.
Danish: Plasmakoncentrationer af aprepitant opnået efter 3dages behandlingsregime med EMEND hos voksne anses for at optage mere end 95 % af hjernens NK1-receptorer.
English: EMEND contains sucrose
Danish: EMEND indeholder saccharose
English: In the same 2 clinical studies, 851 adult patients continued into the Multiple-Cycle extension for up to 5 additional cycles of chemotherapy.
Danish: I de samme to kliniske undersøgelser fortsatte 851 voksne patienter i gentagne kemoterapibehandlinger (multi-cyklus) og op til 5 yderligere kemoterapibehandlinger.
English: In a second multicentre, randomised, double-blind, parallel-group, clinical study, the aprepitant regimen was compared with standard therapy in 848 adult patients (652 females, 196 males) receiving a chemotherapy regimen that included any intravenous dose of oxaliplatin, carboplatin, epirubicin, idarubicin, ifosfamide, irinotecan, daunorubicin, doxorubicin; cyclophosphamide intravenously (< 1,500 mg/m2); or cytarabine intravenously (> 1 g/m2).
Danish: I et andet randomiseret, dobbeltblindet, klinisk multicenterstudie med parallelle grupper blev aprepitantregimet sammenlignet med standardbehandling hos 848 voksne patienter (652 kvinder, 196 mænd), som fik et kemoterapiregime, der inkluderede i.v.-behandling med oxaliplatin, carboplatin, epirubicin, idarubicin, ifosfamid, irinotecan, daunorubicin, doxorubicin, cyclophosphamid (<1.500 mg/m2) eller cytarabin (>1 g/m2).
English: Delayed phase: 25 to 120 hours following initiation of chemotherapy.
Danish: Forsinket fase: 25 til 120 timer efter initiering af kemoterapi.
English: In patients on chronic warfarin therapy, the prothrombin time (INR) should be monitored closely during treatment and for 14 days following the use of EMEND 165 mg for chemotherapy induced nausea and vomiting (see section 4.4).
Danish: Hos patienter i kronisk warfarinbehandling skal protrombintiden (INR) monitoreres omhyggeligt under behandlingen og i 14 dage efter anvendelse af EMEND 165 mg til kvalme og opkastning fremkaldt af kemoterapibehandling (se pkt.
English: The oral suspension should be prepared and the dose measured by healthcare professionals only.
Danish: Det er kun sundhedspersonalet, som må klargøre og afmåle dosis af den orale suspension.
English: Gender No dose adjustment is necessary based on gender (see section 5.2).
Danish: Dosisjustering er ikke nødvendig på baggrund af køn (se pkt.
English: The most common adverse reactions reported at a greater incidence in paediatric patients treated with the aprepitant regimen than with the control regimen while receiving emetogenic cancer chemotherapy were hiccups (3.3 % versus 0.0 %) and flushing (1.1 % versus 0.0 %).
Danish: De hyppigst forekomne bivirkninger, som blev rapporteret med højere incidens ved aprepitantbehandling end ved kontrolbehandling hos de pædiatriske patienter, mens de fik emetogen cancerkemoterapi, var hikke (3,3 % versus 0,0 %) og ansigtsrødme (1,1 % versus 0,0 %).
English: EMEND should be used with caution in these patients (see section 5.2).
Danish: EMEND bør derfor anvendes med forsigtighed til disse patienter (se pkt.
English: If you forget to take EMEND If you or the child has missed a dose, contact your doctor for advice.
Danish: Hvis du eller barnet har glemt at tage en dosis, skal du kontakte lægen for vejledning.
English: PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING (INCLUDING 2 HARD CAPSULES 80 MG)
Danish: MINDSTEKRAV TIL MÆRKNING PÅ DEN INDRE EMBALLAGE (INDEHOLDENDE 2 HÅRDE KAPSLER 80 mg)
English: Inhibition of cytochrome P450 isoenzyme 3A4 (CYP3A4) by aprepitant could result in elevated plasma concentrations of these active substances, potentially causing serious adverse reactions (see section 4.5).
Danish: Aprepitants hæmning af cytokrom P450 isoenzym 3A4 (CYP3A4) kan resultere i forhøjede plasmakoncentrationer i disse aktive substanser, som potentielt kan forårsage alvorlige bivirkninger (se pkt.
English: For CYP2C9 and CYP3A4 substrates, the induction is transient with a maximum effect reached 3-5 days after end of the EMEND 3-day treatment.
Danish: For CYP2C9 og CYP3A4-substrater er induktionen forbigående, og maksimal effekt opnås 3-5 dage efter afslutning af 3-dages EMEND behandling.
English: Before treatment with EMEND, tell the doctor if you or the child have liver disease because the liver is important in breaking down the medicine in the body.
Danish: Før behandling med EMEND skal du fortælle lægen, hvis du eller barnet har en leversygdom, da leveren er vigtig ved nedbrydning af medicinen i kroppen.