FrancophonIA/ELRC3.0 huggingface dataset:
English: Tablet film coat: Hypromellose, titanium dioxide (E171), macrogol, polysorbate 80, iron oxide yellow (E172), iron oxide black (E172)
Danish: Filmovertræk: Hypromellose, titandioxid (E171), macrogol, polysorbat 80, gul jernoxid (E172), sort jernoxid (E172)
English: 20 film-coated tablets 30 film-coated tablets 60 film-coated tablets 80 film-coated tablets 90 film-coated tablets 100 film-coated tablets 500 film-coated tablets
Danish: 20 filmovertrukne tabletter 30 filmovertrukne tabletter 60 filmovertrukne tabletter 80 filmovertrukne tabletter 90 filmovertrukne tabletter 100 filmovertrukne tabletter 500 filmovertrukne tabletter
English: If overdosage occurs the patient should be monitored, and standard supportive treatment applied as required.
Danish: Hvis overdosering finder sted, bør patienten overvåges, og symptomatisk standard-behandling iværksættes om nødvendigt.
English: Creatinine clearance (ml/min) First dose
Danish: Kreatininclearance (ml/min)
English: A very rare side effect that may show up in blood tests is: • a failure of the bone marrow to produce new red blood cells (pure red cell aplasia).
Danish: Meget sjælden bivirkning, der kan ses i blodprøver: • manglende dannelse af nye røde blodceller i knoglemarven (pure red cell aplasi).
English: Lamivudine is well absorbed from the gastrointestinal tract, and the bioavailability of oral lamivudine in adults is normally between 80 and 85%.
Danish: Lamivudin absorberes godt fra mave-tarm-kanalen, og peroral biotilgængelighed hos voksne er normalt 80-85 %.
English: Based on the assumption that creatinine clearance and lamivudine clearance are correlated similarly in children as in adults it is recommended that the dosage in children with renal impairment be reduced according to their creatinine clearance by the same proportion as in adults.
Danish: Ud fra antagelsen, at kreatininclearance og lamivudinclearance korreleres ens hos børn og voksne, anbefales det, at dosis til børn med nedsat nyrefunktion reduceres i forhold til deres kreatininclearance på samme måde som hos voksne.
English: The mean (CV) AUC over a dosing interval of 12 hours is 4.7 µg•h/ml (18%).
Danish: Den gennemsnitlige (CV) AUC over et doseringsinterval på 12 timer er 4,7 μg•h/ml (18 %).
English: Pharmacotherapeutic group: nucleoside analogue, ATC Code: J05AF05.
Danish: Farmakoterapeutisk klassifikation: Nukleosidanalog, ATC-kode: J05AF05.
English: An oral solution is also available for the treatment of children over 3 months of age, or for people who need a lower dose than usual, or who cannot take tablets.
Danish: findes også som oral opløsning til børn over 3 måneder eller til patienter, der har behov for en lavere dosis, eller som ikke kan synke tabletter.
English: Multiple drug antiretroviral therapy containing lamivudine has been shown to be effective in antiretrovirally-naive patients as well as in patients presenting with viruses containing the M184V mutations.
Danish: Flerstof-antiretroviralbehandling, hvor lamivudin er indeholdt, har vist sig at være effektiv hos antiretroviral-naive patienter, såvel som hos patienter, der er smittet med virus, der indeholder M184V-mutationer.
English: • medicines (usually liquids) containing sorbitol and other sugar alcohols (such as xylitol,
Danish: • Lægemidler (oftest opløsninger), der indeholder sorbitol eller andre sukkeralkoholer (som f.eks.
English: Metabolism and nutrition disorders Very rare: Lactic acidosis.
Danish: Metabolisme og ernæring Meget sjælden: Laktacidose
English: Whenever possible in children, lamivudine as tablet formulation should preferably be used.
Danish: Ved behandling af børn med lamivudin, skal tabletformuleringen anvendes, hvor muligt.
English: 1206 paediatric patients aged 3 months to 17 years enrolled in the ARROW Trial (COL105677) and were dosed according to the weight-band dosing recommendations in the World Health Organisation treatment guidelines (Antiretroviral therapy of HIV infection in infants and children, 2006).
Danish: 1.206 pædiatriske patienter i alderen 3 måneder til 17 år blev inkluderet i ARROW-studiet (COL105677) og blev doseret i henhold til vægtgruppe-anbefalingerne i WHO's behandlingsvejledning (Antiretroviral therapy of HIV infection in infants and children, 2006).
English: Triple nucleoside therapy: There have been reports of a high rate of virological failure and of emergence of resistance at an early stage when lamivudine was combined with tenofovir disoproxil fumarate and abacavir as well as with tenofovir disoproxil fumarate and didanosine as a once daily regimen.
Danish: Tripel nukleosidterapi: Der er rapporteret om høj hyppighed af virologisk svigt og forekomst af resistens på et tidligt stadie, når lamivudin kombineres med tenofovirdisoproxilfumarat og abacavir såvel som tenofovirdisoproxilfumarat og didanosin, som et 1 gang daglig regime.
English: Cross-resistance conferred by the M184V RT is limited within the nucleoside inhibitor class of antiretroviral agents.
Danish: Krydsresistens overført af M184V RT er begrænset inden for klassen af nucleosidinhibitorer af antivirale stoffer.
English: Genotypic resistance analyses were conducted on samples with plasma HIV-1 RNA >1000 copies/ml.
Danish: Analyser af genotyperesistens blev udført på prøver med plasma hiv-1 RNA > 1.000 kopier/ml.
English: The study demonstrated that foetuses exposed in utero to the combination sustained a higher level of nucleoside analogueDNA incorporation into multiple foetal organs, and showed evidence of more telomere shortening than in those exposed to zidovudine alone.
Danish: Studiet viste, at fostre, der in utero udsættes for kombinationsbehandlingen, opretholdte et højere niveau af nukleosid-analogt DNA i multiple føtale organer, og udviste også tegn på kortere telomere end dem, der kun fik zidovudin.
English: As the in vitro mutagenic activity of lamivudine could not be confirmed in in vivo tests, it is concluded that lamivudine should not represent a genotoxic hazard to patients undergoing treatment.
Danish: Da lamivudins mutagene aktivitet in vitro ikke kunne bekræftes in vivo, kan det konkluderes, at der ikke skulle være risiko for genotoksicitet hos patienter i behandling med lamivudin.
English: Do not use this medicine after the expiry date which is stated on the container or carton and blister after EXP.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på beholderen eller æsken og blisteren efter Exp. Udløbsdatoen er den sidste dag i den nævnte måned.
English: White opaque PVC/PVdC - Aluminium blisters Pack sizes of 20, 30, 60, 80, 90, 100 or 500 film-coated tablets
Danish: Hvide, uigennemsigtige PVC/PVdC - aluminiumblistere Pakningsstørrelser a 20, 30, 60, 80, 90, 100 eller 500 filmovertrukne tabletter
English: Coadministration of sorbitol solution (3.2 g, 10.2 g, 13.4 g) with a single 300 mg dose of lamivudine oral solution resulted in dose-dependent decreases of 14%, 32%, and 36% in lamivudine exposure (AUC∞) and 28%, 52%, and 55% in the Cmax of lamivudine in adults.
Danish: Samtidig administration af sorbitolopløsning (3,2 g, 10,2 g, 13,4 g) med en enkelt 300 mg dosis lamivudin oral opløsning resulterede i dosisafhængige fald på 14 %, 32 % og 36 % i lamivudineksponering (AUC∞) og 28 %, 52 % og 55 % fald i lamivudins Cmax hos voksne.
English: This conclusion is based on the physicochemical and pharmacokinetic data assuming that the patient crushes and transfers 100% of the tablet and ingests immediately.
Danish: Dette er baseret på fysiskkemiske og farmakokinetiske data og forudsætter, at patienten opblander hele tabletten og at hele mængden indtages straks.
English: Lamivudine is a nucleoside analogue which has activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Danish: Lamivudin er en nukleosidanalog, der er aktiv mod humant immundefekt virus (hiv) og hepatitis B- virus (HBV).
English: The clinical relevance of such findings remains, however, not well defined.
Danish: Den kliniske relevans af disse resultater er dog stadig ikke veldefineret.
English: MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Immediate packaging (blister foil)
Danish: MINDSTEKRAV TIL MÆRKNING PÅ BLISTER ELLER STRIP Indre emballage (blisterfolie)
English: Lamivudine exhibits linear pharmacokinetics over the therapeutic dose range and displays limited binding to the major plasma protein albumin (<16%-36% to serum albumin in in vitro studies).
Danish: Lamivudin udviser lineær farmakokinetik i hele det terapeutiske doseringsinterval med begrænset binding til plasmaproteinet albumin (< 16 % - 36 % til serumalbumin i in vitro-studier).
English: - The active substance is lamivudine.
Danish: - Aktivt stof: Lamivudin.
English: Paediatric population: a randomised comparison of a regimen including once daily vs twice daily dosing of abacavir and lamivudine was undertaken within a randomised, multicentre, controlled study of HIV-infected, paediatric patients.
Danish: Pædiatrisk population: Randomiseret sammenligning af behandling, som indeholdt dosering med abacavir og lamivudin én gang daglig vs. dosering 2 gange daglig blev foretaget indenfor et randomiseret, multicenter, kontrolleret studie med hiv-inficerede pædiatriske patienter.
English: Lamivudine has been widely used as a component of antiretroviral combination therapy with other antiretroviral agents of the same class (NRTIs) or different classes (PIs, non-nucleoside reverse transcriptase inhibitors).
Danish: Lamivudin er i vid udstrækning blevet anvendt som komponent i antiretroviral kombinationsterapi i kombination med andre antiretrovirale stoffer fra den samme gruppe (NRTI'er) eller fra andre grupper (PI'er, non-nukleosid reverse transkriptaseinhibitorer).
English: In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant product information for these medicinal products.
Danish: Ved samtidig behandling af hepatitis B eller C med antivirale midler henvises til oplysninger om disse produkter.
English: The dose should therefore be adjusted, using an oral solution presentation of lamivudine for patients whose creatinine clearance falls below 30 ml/min (see tables).
Danish: Dosis bør derfor justeres ved anvendelse af lamivudin oral opløsning til patienter med kreatininclearance under 30 ml/min (se tabellerne).
English: Administration of lamivudine in animal toxicity studies at high doses was not associated with any major organ toxicity.
Danish: Indgift af høje doser lamivudin i dyretoksicitetsstudier var ikke forbundet med nogen større organtoksicitet.
English: The 150 mg tablet is bioequivalent and dose proportional to the 300 mg tablet with respect to AUC∞, Cmax, and tmax.
Danish: 150 mg tabletten er bioækvivalent og dosisproportional med 300 mg tabletten med hensyn til AUC∞, Cmax og tmax.
English: In 60 healthy adult volunteers, lamivudine 300 mg once daily has been demonstrated to be pharmacokinetically equivalent at steady-state to lamivudine 150 mg twice daily with respect to intracellular triphosphate AUC24 and Cmax.
Danish: Hos 60 raske voksne frivillige er lamivudin 300 mg 1 gang dagligt vist at være farmakokinetisk ækvivalent ved steady-state over for lamivudin 150 mg 2 gange daglig med hensyn til intracellulær triphosphat AUC24 og Cmax.
English: The following adverse reactions have been reported during therapy for HIV disease with lamivudine:
Danish: De følgende bivirkninger er rapporteret under behandling af hiv-sygdom med lamivudin.
English: Summary of Stead-State Plasma Lamivudine AUC (0-24) (µg•h/mL) and Statistical Comparisons for Once and Twice-Daily Oral Administration Across Studies
Danish: Opsummering af steady state lamivudin-AUC (0-24) (µg∙time/ml) i plasma og statistiske sammenligninger af dosering én gang daglig og 2 gange daglig på tværs af studier
English: Lamivudine at a dose of 100 mg once daily has also been shown to be effective for the treatment of adult patients with chronic HBV infection (for details of clinical studies, see the prescribing information for lamivudine 100 mg).
Danish: Lamivudin i en dosering på 100 mg en gang dagligt har vist sig også at være effektiv i behandlingen af voksne patienter med kronisk HBV-infektion (for detaljer vedrørende kliniske studier henvises til produktinformationen for lamivudin 100 mg).
English: The abacavir + lamivudine once daily dosing group was demonstrated to be non-inferior to the twice daily group according to the pre-specified non-inferiority margin of -12%, for the primary endpoint of <80 c/mL at Week 48 as well as at Week 96 (secondary endpoint) and all other thresholds tested (<200 c/mL, <400 c/mL, <1000 c/mL), which all fell well within this non-inferiority margin.
Danish: Abacavir + lamivudin-gruppen, som fik én daglig dosis, blev vist at være non-inferior til gruppen med 2 daglige doser ifølge den præspecificerede non-inferioritetsmargin på -12 % ved det primære endepunkt, som var < 80 kopier/ml ved uge 48, og ligeledes ved uge 96 (sekundært endepunkt) samt alle andre grænser testet (< 200 kopier/ml, < 400 kopier/ml, < 1.000 kopier/ml), som alle var indenfor denne non-inferioritetsmargin.
English: Abacavir maintains its antiretroviral activities against lamivudineresistant HIV-1 harbouring only the M184V mutation.
Danish: Abacavir beholder den antiretrovirale aktivitet over for lamivudin-resistent hiv-1, der kun har M184V-mutationen.
English: Microcrystalline cellulose Sodium starch glycolate (Type A) Magnesium Stearate
Danish: Mikrokrystallinsk cellulose Natriumstivelsesglycolat (Type A) Magnesiumstearat
English: • emtricitabine (used to treat HIV infection).
Danish: • Emtricitabin (mod hiv-infektion)
English: General disorders and administration site conditions Common: Fatigue, malaise, fever.
Danish: Almene symptomer og reaktioner på administrationsstedet Almindelige: Træthed, utilpashed, feber
English: The relationship between in vitro susceptibility of HIV to lamivudine and clinical response to lamivudine-containing therapy remains under investigation.
Danish: Forholdet mellem in vitro-følsomheden af hiv over for lamivudin og det kliniske respons af behandling, hvor lamivudin er indeholdt undersøges forsat.
English: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Danish: Inden for hver gruppe af bivirkninger med samme frekvens er bivirkningerne opstillet efter faldende alvorlighed.
English: Each film-coated tablet contains 300 mg. - The other ingredients are:
Danish: Hver filmovertrukket tablet indeholder 300 mg. - Øvrige indholdsstoffer:
English: Dosing recommendations - Children aged at least 3 months and weighing less than 25 kg: Creatinine clearance (ml/min) First dose
Danish: Anbefalet dosering - børn over 3 måneder og med en vægt på mindre end 25 kg: Kreatininclearance (ml/min)
English: Co-administration of lamivudine with high doses of co-trimoxazole for the treatment of Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis should be avoided.
Danish: Samtidig administration af lamivudin og høje doser af trimethoprim/sulfamethoxazol til behandling af Pneumocystis jirovecii-pneumoni (PCP) og toxoplasmose bør undgås.
English: MARKETING AUTHORISATION NUMBER(S) EU/1/09/596/007
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/09/596/007
English: 30 to<50
Danish: 30 til < 50
English: Administration of co-trimoxazole with lamivudine in patients with renal impairment should be carefully assessed.
Danish: Indgift af co-trimoxazol sammen med lamivudin til patienter med nedsat nyrefunktion bør vurderes omhyggeligt.
English: -2.3% (95% CI -9.3% to +4.7%), p=0.52
Danish: -2,3 % (95 % CI -9,3 % til +4,7 %), p=0,52
English: Renal impairment: In patients with moderate to severe renal impairment, the terminal plasma half-life of lamivudine is increased due to decreased clearance; therefore the dose should be adjusted (see section 4.2).
Danish: Nedsat nyrefunktion: Hos patienter med moderat til svært nedsat nyrefunktion er den terminale plasmahalveringstid af lamivudin øget på grund af nedsat clearance; derfor bør dosis justeres (se pkt.
English: Ask your pharmacist how to throw away the medicines you no longer use.
Danish: Spørg apotekspersonalet, hvordan du skal bortskaffe medicinrester.
English: • other medicines containing lamivudine, (used to treat HIV infection or hepatitis B infection).
Danish: • Andre lægemidler, der indeholder lamivudin (mod hiv-infektion eller hepatitis B-infektion)
English: Pregnancy: Following oral administration, lamivudine pharmacokinetics in late-pregnancy were similar to non-pregnant women.
Danish: Graviditet: Farmakokinetikken af oral lamivudin sent i graviditeten svarede til den hos ikke-gravide kvinder.
English: Dosing recommendations - Adults, adolescents and children (weighing at least 25 kg):
Danish: Anbefalet dosering - voksne, unge og børn (der vejer mindst 25 kg):
English: Proportions of Subjects in the Once Daily versus Twice Daily Abacavir+Lamivudine Randomisation of ARROW with Plasma HIV-1 RNA <80 copies/ml: Subgroup Analysis by Formulation
Danish: Andele af personer i én gang daglig versus to gange daglig randomisering til abacavir+lamivudin af ARROW med plasma hiv-1 RNA < 80 kopier/ml: Subgruppeanalyse efter formulering
English: MARKETING AUTHORISATION NUMBER(S) EU/1/09/596/014
Danish: MARKEDSFØRINGSTILLADELSESNUMMER (-NUMRE) EU/1/09/596/014
English: To ensure the administration of the entire dose, the tablet(s) should ideally be swallowed without crushing.
Danish: For at sikre optagelse af hele dosis bør tabletterne synkes hele og ikke knuses.
English: Lamivudine is also available as an oral solution for children over three months of age and who weigh less than 14 kg or for patients who are unable to swallow tablets (see section 4.4).
Danish: Lamivudin findes også som oral opløsning til børn over 3 måneder, som vejer mindre end 14 kg, eller til patienter med synkebesvær (se pkt.
English: Any solution regimen at any time All tablet based regimen throughouts
Danish: Hvilket som helst regime med opløsninger til hver tid
English: Tell your doctor or pharmacist if any of the side effects gets severe or troublesome, or if you notice any side effects not listed in this leaflet.
Danish: Tal med lægen eller apotekspersonalet, hvis en bivirkning er generende eller bliver værre, eller du får bivirkninger, som ikke er nævnt i denne indlægsseddel.
English: Following oral administration lamivudine was excreted in breast milk at similar concentrations to those found in serum.
Danish: Efter peroral administration blev lamivudin udskilt i brystmælk i koncentrationer svarende til serumkoncentrationerne.
English: • cladribine (used to treat hairy cell leukaemia).
Danish: • Cladribin (mod hårcelleleukæmi).
English: Virological Response Based on Plasma HIV-1 RNA less than 80 copies/ml at Week 48 and Week 96 in the Once Daily versus Twice Daily abacavir + lamivudine randomisation of ARROW (Observed Analysis)
Danish: Virologisk respons baseret på hiv-1-RNA under 80 kopier/ml plasma ved uge 48 og uge 96 ved én gang daglig versus 2 gange daglig dosering af abacavir + lamivudin; randomisering af ARROW (observationsanalyse)
English: Patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
Danish: Hos patienter med leverinsufficiens, herunder kronisk aktiv hepatitis, ses oftere abnorm leverfunktion i forbindelse med den antiretrovirale behandling, og disse patienter skal kontrolleres jf. standardpraksis.
English: Administration of trimethoprim/sulfamethoxazole 160 mg/800 mg results in a 40% increase in lamivudine exposure, because of the trimethoprim component; the sulfamethoxazole component did not interact.
Danish: Administration af trimethoprim/sulfamethoxazol 160 mg/800 mg øger ekspositionen af lamivudin med 40 % på grund af trimethoprimdelen.
English: White opaque HDPE tablet containers with white opaque polyethylene child resistant screw cap with induction seal.
Danish: Hvide, uigennemsigtige HDPE-tabletbeholdere med hvidt, uigennemsigtigt, børnesikret polyethylenskruelåg med induktionsforsegling.
English: Tablet containers
Danish: Tabletbeholdere
English: NN:
Danish: indeholder:
English: Administration of lamivudine tablets is bioequivalent to lamivudine oral solution with respect to AUC∞ and Cmax in adults.
Danish: Lamivudin-tabletter er bioækvivalente med lamivudin oral opløsning med hensyn til AUC∞ og Cmax hos voksne.
English: At a therapeutic dose of 300 mg once daily, the mean (CV) steady-state Cmax, Cmin and 24h AUC are 2.0 µg/ml (26%), 0.04 µg/ml (34%) and 8.9 µg•h/ml (21%), respectively.
Danish: Ved en terapeutisk dosis på 300 mg én gang daglig er den gennemsnitlige (CV) steady state Cmax, Cmin og 24 timers AUC henholdsvis 2,0 μg/ml (26 %), 0,04 μg/ml (34 %) og 8,9 μg•h/ml (21 %).
English: Patients changing between lamivudine oral solution and lamivudine tablets should follow the dosing recommendations that are specific for the formulation (see section 5.2)
Danish: Patienter der skifter mellem lamivudin oral opløsning og lamivudin tabletter bør følge dosisanbefalingerne, der gælder for den specifikke lægemiddelform (se pkt.
English: In clinical trials, lamivudine in combination with zidovudine has been shown to reduce HIV-1 viral load and increase CD4 cell count.
Danish: Kliniske studier har vist, at lamivudin i kombination med zidovudin kan reducere hiv-1-virusbyrden samt øge CD4-celletallet.
English: Children receiving lamivudine oral tablets according to the recommended dosage regimen achieve higher plasma lamivudine exposure than children receiving oral solution because higher mg/kg doses are administered with the tablet formulation and the tablet formulation has higher bioavailability (see section 4.2).
Danish: Børn, som får lamivudintabletter i henhold til doseringsanbefalingerne, opnår højere lamivudin-plasmaniveauer end børn, som får oral opløsning, da der administreres højere mg/kg-doser med tabletformuleringen, som også har højere biotilgængelighed (se pkt.
English: Remember to tell your doctor or pharmacist if you begin taking a new medicine while you are taking Lamivudine Teva Pharma B.V..
Danish: Husk at fortælle det til lægen eller på apoteket, hvis du begynder at tage ny medicin, mens du er i behandling med Lamivudin Teva Pharma B.V.
English: A 150 mg strength Lamivudine Teva Pharma B.V. tablet is also available for the treatment of children from 3 months of age who weigh less than 25 kg.
Danish: fås også som en 150 mg tablet til behandling af børn fra 3 måneder, der vejer under 25 kg.
English: • a decrease in the number of cells involved in blood clotting (thrombocytopenia)
Danish: • nedsat antal af blodceller, der har betydning for blodets evne til at størkne (trombocytopeni)
English: NAME OF THE MARKETING AUTHORISATION HOLDER TEVA B.V.
Danish: NAVN PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN TEVA B.V.
English: Tablet core: Microcrystalline cellulose, sodium starch glycolate, magnesium stearate.
Danish: Tabletkerne: Mikrokrystallinsk cellulose, natriumstivelsesglycolat, magnesiumstearat.
English: It is recommended that HIV infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.
Danish: For at undgå transmissionen af hiv anbefales det, at hivinficerede kvinder under ingen omstændigheder ammer deres børn.
English: -4.8% (95% CI -11.5% to +1.9%), p=0.16 Week 48
Danish: -4,8 % (95 % CI -11,5 % til +1,9 %), p=0,16
English: Once daily dosing (300 mg once a day): a clinical study has demonstrated the non-inferiority between lamivudine once a day and lamivudine twice a day containing regimens.
Danish: Engangsdosering (300 mg 1 gang dagligt): Et klinisk studie har vist, at der ikke er forskel på dosering af lamivudin 1 gang daglig og lamivudin 2 gange daglig.
English: Liver disease: If lamivudine is being used concomitantly for the treatment of HIV and HBV, additional information relating to the use of lamivudine in the treatment of hepatitis B infection is available in the lamivudine 100 mg SmPC.
Danish: Leversygdom: Hvis lamivudin anvendes samtidig til behandling af såvel hiv som HBV, kan der findes yderligere information i produktresumeet for lamivudin 100 mg vedrørende behandlingen af hepatitis B med lamivudin.