FrancophonIA/ELRC3.0 huggingface dataset:
English: This indicates a low likelihood for interactions with other medicinal products through plasma protein binding displacement.
Croatian: To upućuje na malu vjerojatnost interakcije s drugim lijekovima uslijed istiskivanja s mjesta vezanja na proteine plazme.
English: The safety and efficacy of Trizivir in adolescents and children has not been established.
Croatian: Sigurnost i djelotvornost lijeka Trizivir u adolescenata i djece nisu ustanovljene.
English: Separate administration of Trizivir and clarithromycin by at least 2 hours
Croatian: Odvojena administracija lijeka Trizivir i klaritromicina s razmakom od barem 2 sata klaritromicin/lamivudin
English: When these signs occur, Trizivir should be stopped and your HIV treatment changed.
Croatian: Kad se ti znakovi pojave, valja prekinuti primjenu lijeka Trizivir i promijeniti Vaše liječenje HIV-a.
English: The absolute bioavailability of oral abacavir, lamivudine and zidovudine in adults is about 83 %, 80 - 85 % and 60 - 70 % respectively.
Croatian: Apsolutna bioraspoloživost peroralnog oblika abakavira, lamivudina i zidovudina u odraslih iznosi, prema redoslijedu navođenja, oko 83%, 80-85% te 60-70%.
English: Corresponding values for Cmin could not be established for abacavir and are 0.14 µg/ml (70 %) for lamivudine and 0.01 µg/ml (64 %) for zidovudine.
Croatian: Odgovarajuće vrijednosti Cmin nisu se mogle utvrditi za abakavir dok su za lamivudin bile 0,14 µg/ml (70 %) i 0,01 µg/ml (64 %) za zidovudin.
English: Lactic acidosis has a high mortality and may be associated with pancreatitis, liver failure, or renal failure.
Croatian: Laktacidoza ima visok mortalitet i može biti udružena s pankreatitisom, zatajenjem jetre ili bubrega.
English: No clinical data are available in patients with moderate or severe hepatic impairment, therefore the use of Trizivir is not recommended unless judged necessary.
Croatian: Nema kliničkih podataka za bolesnike s umjerenim ili teškim oštećenjem funkcije jetre, stoga se ne preporučuje primjena lijeka Trizivir osim ako se procijeni da je neophodna.
English: These haematological effects are not usually observed before four to six week's therapy.
Croatian: Učinci na hematološki sustav obično se ne javljaju tijekom prvih 4 - 6 tjedana liječenja.
English: Common: anaemia, neutropenia and leucopenia
Croatian: Često: anemija, neutropenija i leukopenija
English: Based on data obtained for abacavir, Trizivir is not recommended in patients with moderate or severe hepatic impairment.
Croatian: Na temelju podataka dobivenih za abakavir i zidovudin, Trizivir se ne preporučuje u bolesnika s umjerenim ili teškim oštećenjem funkcije jetre.
English: Common: rash, alopecia
Croatian: Često: osip, alopecija
English: Clinical studies have shown that there are no clinically significant interactions between abacavir, lamivudine and zidovudine.
Croatian: Klinička ispitivanja pokazala su da nema klinički značajnih interakcija između abakavira, lamivudina i zidovudina.
English: Haemodialysis and peritoneal dialysis appear to have a limited effect on elimination of zidovudine, but enhance the elimination of the glucuronide metabolite.
Croatian: Čini se da hemodijaliza i peritonealna dijaliza imaju ograničen učinak na izlučivanje zidovudina, ali pospješuju izlučivanje metabolita glukuronida.
English: Treatment with zidovudine has been associated with cases of lactic acidosis, sometimes fatal, usually associated with severe hepatomegaly and hepatic steatosis, (see section 4.4).
Croatian: Laktacidoza Prilikom primjene zidovudina zabilježeni su slučajevi laktacidoze, ponekad sa smrtnim ishodom, a obično udruženi s teškom hepatomegalijom i hepatičkom steatozom (vidjeti dio 4.4).
English: This helps your body to increase the CD4 cell count in your blood.
Croatian: To pomaže organizmu da poveća broj CD4
English: Opadry Green 03B11434 containing: hypromellose, titanium dioxide, polyethylene glycol, indigo carmine aluminium lake, iron oxide yellow.
Croatian: Opadry Green 03B11434 sadrži: hipromelozu, titanijev dioksid, polietilenglikol, boju indigo carmine aluminium lake i željezov oksid, žuti.
English: Hypersensitivity reactions can start at any time during treatment with Trizivir, but are more likely during the first 6 weeks of treatment.
Croatian: Reakcije preosjetljivosti mogu započeti u bilo koje vrijeme terapije lijekom Trizivir, no najčešće tijekom prvih 6 tjedana liječenja.
English: Occasionally, hypersensitivity reactions have developed in people who start taking abacavir containing products again, but who had only one symptom on the Alert Card before they stopped taking it.
Croatian: Ponekad su se reakcije preosjetljivosti razvile u osoba koje su ponovno počele uzimati lijekove koji sadrže abakavir, a imale su samo jedan simptom naveden na Kartici s upozorenjima prije nego što su ga prestale uzimati.
English: For general Trizivir information enquiries, contact (local company name and telephone number inserted here)
Croatian: Za općenite informacije o lijeku Trizivir kontaktirajte (umetnuti naziv lokalnog predstavnika i broj telefona)
English: • irritated or runny nose
Croatian: • iritacija nosa ili curenje nosa
English: Common: headache, insomnia Very rare: peripheral neuropathy (paraesthesiae)
Croatian: Često: glavobolja, nesanica Vrlo rijetko: periferna neuropatija (parestezije)
English: There were no other zidovudine-related tumours observed in either sex of either species.
Croatian: Nisu zabilježene druge neoplazme vezane uz primjenu zidovudina u bilo kojeg spola obje vrste.
English: During your treatment, your doctor will monitor you for signs of lactic acidosis.
Croatian: Za vrijeme liječenja liječnik će Vas nadzirati zbog moguće pojave znakova laktacidoze.
English: Dose reduction is required for patients with creatinine clearance ≤ 50 ml/min (see section 4.2).
Croatian: Preporučuje se smanjenje doze lamivudina u bolesnika s klirensom kreatinina ≤ 50 ml/min (vidjeti dio 4.2).
English: A large amount of data on pregnant women taking lamivudine or zidovudine indicate no malformative toxicity (more than 3000 outcomes from first trimester exposure each, of which over 2000 outcomes involved exposure to both lamivudine and zidovudine).
Croatian: Velika količina podataka koja se odnosi na trudnice koje su uzimale lamivudin ili zidovudin upućuje da ne postoji malformacijska toksičnost (više od 3000 ishoda za izloženost tijekom prvog trimestra, od kojih je njih 2000 bilo izloženo i lamivudinu i zidovudinu).
English: Similarly, the presence of TAMs gives rise to resistance to ZDV.
Croatian: Slično tome, prisustvo mutacija analoga timidina (TAMs) pogoduje stvaranju rezistencije na ZDV.
English: The degree of benefit of this nucleoside combination in heavily pre-treated patients will depend on the nature and duration of prior therapy that may have selected for HIV-1 variants with cross-resistance to abacavir, lamivudine or zidovudine.
Croatian: Stupanj koristi ove nukleozidne kombinacije u bolesnika koji su ranije primali jaku terapiju ovisit će o prirodi i trajanju ranijeg liječenja tijekom kojeg je možda došlo do selekcioniranja HIV-1 varijanti s ukriženom rezistencijom na abakavir, lamivudin ili zidovudin.
English: These changes are not considered clinically relevant and no food restrictions are recommended for administration of Trizivir.
Croatian: Te promjene ne smatraju se klinički značajnima te se pri primjeni lijeka Trizivir ne preporučuju ograničenja vezana uz hranu.
English: Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse reactions.
Croatian: Bolesnici s kroničnim hepatitisom B ili C koji su na kombiniranoj antiretrovirusnoj terapiji imaju povećani rizik od nastupa teških i potencijalno fatalnih jetrenih nuspojava.
English: • In order to avoid restarting abacavir patients who have experienced a suspected HSR should be instructed to dispose of their remaining Trizivir tablets
Croatian: • Kako bi se izbjeglo ponovno uzimanje abakavira, bolesnike koji su imali suspektnu reakciju preosjetljivosti mora se uputiti da zbrinu preostale Trizivir tablete.
English: Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterium infections, and Pneumocystis jirovecii pneumonia.
Croatian: Relevantni primjeri uključuju citomegalovirusom izazvani retinitis, generalizirane i/ili fokalne infekcije mikobakterijama i pneumoniju izazvanu s Pneumocystis jirovecii.
English: The overall selection frequency for M184V or M184I was high (85 %), and selection of L74V, K65R and Y115F was not observed (see Table).
Croatian: Ukupna učestalost selekcije M184V ili M184I je bila visoka (85%), dok selekcije L74V, K65R i Y115F nisu opažene (vidi Tablicu u tekstu koji slijedi).
English: Trizivir is used to treat HIV (human immunodeficiency virus) infection in adults.
Croatian: Trizivir je namijenjen liječenju infekcije HIV-om (virusom humane imunodeficijencije) u odraslih bolesnika.
English: Limited data from clinical trials do not indicate a significantly increased risk of adverse reactions to zidovudine with cotrimoxazole (see interaction information above relating to lamivudine and cotrimoxazole), aerosolised pentamidine, pyrimethamine and acyclovir at doses used in prophylaxis.
Croatian: Ograničeni podaci iz kliničkih ispitivanja ne upućuju na značajno povišen rizik za razvoj nuspojava zbog kombinacije zidovudina s kotrimoksazolom (vidjeti informacije vezane za interakcije u tablici iznad koje se odnose lamivudin i kotrimoksazol), aerosolni pentamidin, pirimetamin i aciklovir u dozama koje se koriste kao profilaksa.
English: The pharmacokinetics of abacavir have been studied in patients with mild hepatic impairment (Child-Pugh score 5-6) receiving a single 600 mg dose; the median (range) AUC value was 24.1 (10.4 to 54.8) ug.h/ml.
Croatian: Farmakokinetika abakavira ispitivana je u bolesnika s blagim oštećenjem funkcije jetre (Child-Pugh skor 5-6) koji su primili jednokratnu dozu od 600 mg; medijan (raspon) AUC vrijednosti bio je 24.1 (10.4 do 54,8) ug.h/ml.
English: Do not take this medicine after the expiry date shown on the carton.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza oznake „EXP“.
English: This fixed combination replaces the three components (abacavir, lamivudine and zidovudine) used separately in similar doses.
Croatian: Fiksna kombinacija u ovom lijeku zamjenjuje tri komponente (abakavir, lamivudin i zidovudin) korištene odvojeno u sličnim dozama.
English: • ribavirin or injections of ganciclovir to treat viral infections
Croatian: • ribavirin ili injekcije ganciklovira za liječenje virusnih infekcija
English: Trizivir contains three active ingredients that are used to treat HIV infection: abacavir, lamivudine and zidovudine.
Croatian: Trizivir sadrži tri djelatne tvari koje se koriste u liječenju HIV infekcija: abakavir, lamivudin i zidovudin.
English: - fever
Croatian: - vrućica
English: Early symptoms (symptomatic hyperlactatemia) include benign digestive symptoms (nausea, vomiting and abdominal pain), non-specific malaise, loss of appetite, weight loss, respiratory symptoms (rapid and/or deep breathing) or neurological symptoms (including motor weakness).
Croatian: Rani simptomi (simptomatska hiperlaktatemija) uključuju benigne probavne smetnje (mučninu, povraćanje i bol u abdomenu), nespecifičnu malaksalost, gubitak apetita, gubitak na težini, respiratorne simptome (ubrzano i/ili duboko disanje) ili neurološke simptome (uključujući motoričku slabost).
English: When concomitant administration with cotrimoxazole is warranted, patients should be monitored clinically.
Croatian: Kada je neizbježna istodobna terapija s kotrimoksazolom bolesnik bi se morao klinički nadzirati.
English: The pharmacokinetics of abacavir in patients with end-stage renal disease is similar to patients with normal renal function, and, therefore, no dose reduction is required in patients with renal impairment.
Croatian: Farmakokinetika abakavira u bolesnika u završnom stadiju bubrežne bolesti slična je kao u bolesnika s normalnom funkcijom bubrega i, prema tome, u bolesnika s oštećenjem funkcije bubrega nije potrebno smanjenje doze.
English: Trizivir is indicated for the treatment of Human Immunodeficiency Virus (HIV) infection in adults (see sections 4.4 and 5.1).
Croatian: Trizivir je indiciran za liječenje infekcije uzrokovane virusom humane imunodeficijencije (HIV) u odraslih osoba (vidjeti dijelove 4.4 i 5.1).
English: The results showed that there was a mean (90%CI) increase of 1.89 fold [1.32; 2.70] in the abacavir AUC, and 1.58 [1.22; 2.04] fold in the elimination half-life.
Croatian: Rezultati su pokazali srednji (90% CI) porast AUC-a abakavira od 1,89 puta [1,32; 2,70] te produljenje poluvremena eliminacije za 1,58 puta [1,22; 2,04].
English: IMPORTANT: for information on abacavir hypersensitivity see the information below, under the Description of selected adverse reactions
Croatian: VAŽNO: za informacije o preosjetljivosti na abakavir vidjeti informacije u nastavku, navedene u dijelu 'Opis odabranih nuspojava: Preosjetljivost na abakavir'
English: ACTG5095 was a randomised (1:1:1), double-blind, placebo-controlled trial performed in 1147 antiretroviral naïve HIV-1 infected adults, comparing 3 regimens: zidovudine (ZDV), lamivudine (3TC), abacavir (ABC), efavirenz (EFV) vs ZDV/3TC/EFV vs ZDV/3TC/ABC.
Croatian: ACTG5095 je bilo randomizirano (1:1:1), dvostruko slijepo ispitivanje kontrolirano placebom, provedeno na 1147 odraslih osoba zaraženih virusom HIV-1 koji ranije nisu primali antiretrovirusnu terapiju u kojem se uspoređivalo 3 režima: zidovudin (ZDV), lamivudin (3TC), abakavir (ABC),
English: Read the information ‘Other possible side effects of Trizivir' in Section 4 of this leaflet.
Croatian: Pozorno pročitajte informacije 'Ostale moguće nuspojave lijeka Trizivir' u dijelu 4 ove
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 2 January 2001
Croatian: Datum prvog odobrenja: 2. siječnja 2001.
English: Talk to your doctor before you start again.
Croatian: Obavijestite svog liječnika prije nego ponovno započnete s terapijom.
English: Trimethoprim: AUC ↔ Sulfamethoxazole: AUC ↔
Croatian: trimetoprim: AUC ↔ sulfametoksazol: AUC ↔
English: 2) you get one or more symptoms from at least TWO of the following groups
Croatian: 2) razvijete jedan ili više simptoma iz barem DVIJE od sljedećih skupina: - vrućica
English: In a pharmacokinetic study in HIV-1 infected patients, the steady state pharmacokinetic parameters of abacavir, lamivudine and zidovudine were similar when either Trizivir alone or the combination tablet lamivudine/zidovudine and abacavir in combination were administered, and also similar to the values obtained in the bioequivalence study of Trizivir in healthy volunteers.
Croatian: U farmakokinetičkom ispitivanju provedenom na bolesnicima zaraženima virusom HIV-1, farmakokinetički parametri dinamičke ravnoteže abakavira, lamivudina i zidovudina bili slični onima dobivenim kod primjene samo lijeka Trizivir ili onima kod primjene kombinirane terapije tabletom s kombinacijom lamivudina/zidovudina i abakavirom, a slični su bili i vrijednostima dobivenima u ispitivanju bioekvivalencije lijeka Trizivir koje se provodilo na zdravim dobrovoljcima.
English: Neither abacavir, lamivudine nor zidovudine is mutagenic in bacterial tests, but consistent with other nucleoside analogues, they inhibit cellular DNA replication in in vitro mammalian tests such as the mouse lymphoma assay.
Croatian: Ni abakavir ni lamivudin ni zidovudin nisu bili mutageni u bakterijskim testovima, ali poput mnogih analoga nukleozida oni inhibiraju replikaciju stanične DNK u testovima na sisavcima in vitro npr. na stanicama limfoma miša.
English: If ABC hypersensitivity cannot be ruled out, ABC should be permanently discontinued, regardless of the results of HLA-B*5701 screening.
Croatian: U slučaju da se preosjetljivost na ABC ne može isključiti, ABC se mora trajno isključiti iz terapije, bez obzira na rezultate HLA-B*5701 probira.
English: Lactic acidosis, usually associated with hepatomegaly and hepatic steatosis, has been reported with the use of zidovudine .
Croatian: Laktacidoza Laktacidoza, obično udružena s hepatomegalijom i hepatalnom steatozom zabilježena je prilikom primjene zidovudina.
English: In addition, the selection of L74V and K65R was reduced when co-administered with ZDV (K65R: without ZDV: 13/127, 10 %; with ZDV: 1/86, 1 %; L74V: without ZDV: 51/127, 40 %; with ZDV: 2/86, 2 %).
Croatian: K65R se smanjuje kada se daje zajedno sa ZDV (K65R: bez ZDV: 13/127, 1%; sa ZDV: 1/86, 1%; L74V: bez ZDV: 51/127, 40%; L74V: sa ZDV: 2/86, 2%).
English: No specific symptoms or signs have been identified following acute overdose with zidovudine or lamivudine apart from those listed as adverse reactions.
Croatian: Nisu uočeni nikakvi specifični simptomi ni znakovi kao posljedica akutnog predoziranja zidovudinom ili lamivudinom, osim onih navedenih u dijelu o nuspojavama.
English: Plasma protein binding studies in vitro indicate that abacavir binds only low to moderately (~ 49 %) to human plasma proteins at therapeutic concentrations.
Croatian: Ispitivanja o vezanju na proteine plazme in vitro pokazuju da se abakavir u terapijskim koncentracijama veže slabo do umjereno (∼ 49%) na proteine ljudske plazme.
English: These occurred more frequently at higher zidovudine doses (12001500 mg/day) and in patients with poor bone marrow reserve prior to treatment, particularly with advanced HIV disease.
Croatian: Ove nuspojave se javljaju češće u bolesnika koji primaju visoke doze zidovudina (1200 - 1500 mg/dan) i u bolesnika s iscrpljenim zalihama koštane srži prije početka liječenja, posebice u bolesnika s uznapredovalom HIV bolešću.
English: Take special care with Trizivir
Croatian: Budite posebno oprezni s lijekom Trizivir
English: Zidovudine concentrations are increased in patients with advanced renal failure.
Croatian: Koncentracije zidovudina su povišene u bolesnika s uznapredovalim zatajenjem bubrega.
English: Treatment related findings were limited to lateoccurring vaginal epithelial tumours, which were seen with a similar incidence and time of onset as in the standard oral carcinogenicity study.
Croatian: Jedine posljedice primjene lijeka bili su kasni tumori vaginalnog epitela koji su se javljali približno u isto vrijeme i jednako često kao i u standardnoj studiji oralne karcinogenosti.
English: Treatment with zidovudine has been associated with loss of subcutaneous fat, which has been linked to mitochondrial toxicity.
Croatian: Liječenje zidovudinom bilo je povezano s gubitkom potkožnog masnog tkiva, što se povezalo s toksičnim učinkom na mitohondrije.
English: The mean (CV) AUCs for abacavir, lamivudine and zidovudine over a dosing interval of 12 hours are 6.39 µg.h/ml (31 %), 5.73 µg.h/ml (31 %) and 1.50 µg.h/ml (47 %), respectively.
Croatian: Srednje vrijednosti (CV) AUC za abakavir, lamivudin i zidovudin tijekom razdoblja doziranja od 12 sati bile su redom 6,39 µg.h/ml (31%), 5,73 µg.h/ml (31%) i 1,50 µg.h/ml (47%).
English: The study demonstrated that foetuses exposed in utero to the combination sustained a higher level of nucleoside analogue-DNA incorporation into multiple foetal organs, and showed evidence of more telomere shortening than in those exposed to zidovudine alone.
Croatian: Ispitivanje je pokazalo da je kod fetusa koji su in utero bili izloženi kombinaciji došlo do opsežnije ugradnje DNK analoga nukleozida u više fetalnih organa i do većeg skraćivanja telomera nego kod onih koji su bili izloženi samo zidovudinu.
English: They are blue/green and capsuleshaped and are provided in blister packs containing 60 tablets or bottles containing 60 tablets with child-resistant tops.
Croatian: Plavo/zelene su boje i oblika kapsule, a dostupne su u blister pakiranjima od 60 tableta i bočicama sa sigurnosnim poklopcem za djecu koje sadrže 60 tableta.
English: In vitro data tend to suggest that the continuation of lamivudine in anti-retroviral regimen despite the development of M184V might provide residual anti-retroviral activity (likely through impaired viral fitness).
Croatian: Podaci in vitro upućuju da bi se nastavkom primjene lamivudina unatoč razvoju M184V moglo osigurati rezidualno antiretrovirusno djelovanje (vjerojatno zbog oštećenja sposobnosti replikacije virusa).
English: • liver disorders, such as jaundice, enlarged liver or fatty liver, inflammation (hepatitis)
Croatian: • poremećaji jetre, kao što su žutica, povećana ili 'masna' jetra, upala (hepatitis)
English: In a meta-analysis of five clinical trials where abacavir was added to intensify therapy, of 166 subjects, 123 (74 %) had M184V/I, 50 (30 %) had T215Y/F, 45 (27%) had M41L, 30 (18 %) had K70R and 25 (15%) had D67N.
Croatian: U metaanalizi 5 kliničkih ispitivanja u kojima je abakavir dodan kako bi se pojačala terapija, od ukupnog broja od 166 bolesnika, 123 (74%) je imalo M184V/I, 50 (30%) je imalo T215Y/F, 45 (27%) je imalo M41L, 30 (18%) je imalo K70R, a 25 (15%) je imalo D67N.
English: • difficulty moving
Croatian: • otežano kretanje.
English: As only limited data available the clinical significance is unknown.
Croatian: Dostupni samo ograničeni podaci te klinička značajnost nije poznata.
English: Rare: gynaecomastia
Croatian: Rijetko: ginekomastija
English: Trizivir does not cure HIV infection; it reduces the amount of virus in your body, and keeps it at a low level.
Croatian: On smanjuje količinu virusa u Vašem tijelu i održava je na niskoj razini.
English: Due to the active substance zidovudine, Trizivir is contraindicated in patients with abnormally low neutrophil counts (< 0.75 x 109/l), or abnormally low haemoglobin levels (< 7.5 g/dl or 4.65 mmol/l) (see section 4.4).
Croatian: Zbog djelatne tvari zidovudina, Trizivir je kontraindiciran u bolesnika s abnormalno niskim brojem neutrofila (< 0,75 x 109/l) ili abnormalno niskim razinama hemoglobina (< 7,5 g/dl ili 4,65 mmol/l) (vidjeti dio 4.4).
English: No pharmacokinetic data are available in patients over 65 years of age.
Croatian: Starije osobe: nisu dostupni farmakokinetički podaci u bolesnika starijih od 65 godina.
English: The presence of M184V with K65R does give rise to crossresistance between abacavir, tenofovir, didanosine and lamivudine, and M184V with L74V gives rise to cross-resistance between abacavir, didanosine and lamivudine.
Croatian: Prisustvo M184V s K65R uzrokuje križnu rezistenciju između abakavira, tenofovira, didanozina i lamivudina, a prisustvo M184V s L74V
English: Trizivir may cause other conditions to develop during HIV treatment.
Croatian: Trizivir može uzrokovati druga stanja koja se mogu razviti za vrijeme liječenja HIV-a.
English: Renal clearance of zidovudine is estimated to be 0.34 l/h/kg, indicating glomerular filtration and active tubular secretion by the kidneys.
Croatian: Renalni klirens zidovudina procijenjen je na 0,34 l/h/kg, upućujući na pretežno izlučivanje glomerularnom filtracijom i aktivnom tubularnom sekrecijom.
English: The mean systemic clearance of lamivudine is approximately 0.32 l/h/kg, with predominantly renal clearance (> 70 %) via the organic cationic transport system.
Croatian: Srednja vrijednost sistemskog klirensa lamivudina iznosi oko 0,32 l/h/kg, najvećim dijelom bubrežnim klirensom (> 70%) preko organskog kationskog transportnog sistema.
English: K65R was absent and L74V and Y115F were uncommon (≤3 %).
Croatian: Nije ustanovljen K65R, dok su se L74V i Y115F javili manje često (≤3%).
English: Tabulated list of adverse reactions reported with the individual substances
Croatian: Tablični prikaz nuspojava prijavljenih prema pojedinoj tvari
English: Thymidine analogue mutations (TAMs) which are selected by zidovudine (ZDV) were also found (8%).
Croatian: Pronađene su mutacije (8%) analoga timidina (TAM) koje su selektirane zidovudinom (ZDV).