FrancophonIA/ELRC3.0 huggingface dataset:
English: If you take more Capecitabine SUN than you should Contact your doctor as soon as possible before taking the next dose.
Danish: Kontakt din læge så hurtigt som muligt, før du tager næste dosis.
English: Palmar-plantar erythrodysaesthesia syndrome
Danish: Palmarplantar erytrodysæsthesi syndrom
English: In addition to the above, when Capecitabine SUN is used alone, very common side effects which may affect more than 1 person in 10 are: - abdominal pain - rash, dry or itchy skin - tiredness - loss of appetite (anorexia).
Danish: Udover dette kan Capecitabin SUN, når det anvendes alene, have følgende meget almindelige bivirkninger, som kan påvirke flere end 1 person ud af 10: - mavesmerter - udslæt, tør eller kløende hud - træthed - appetitløshed.
English: 1) or the Common Terminology Criteria for Adverse Events (CTCAE) of the Cancer Therapy Evaluation Program, US National Cancer Institute, version 4.0.
Danish: *I følge National Cancer Institute of Canada Clinical Trial Group (NCIC CTG) Common Toxicity Criteria (version 1) eller Common Terminology Criteria for Adverse Events (CTCAE) fra Cancer Therapy Evaluation Program, US National Cancer Institute, version 4.0.
English: Do not take Capecitabine SUN - if you are allergic to capecitabine or any of the other ingredients of this medicine (listed in section 6).
Danish: Tag ikke Capecitabin SUN - hvis du er allergisk over for capecitabin eller et af de øvrige indholdsstoffer i capecitabin (angivet i pkt.
English: Oxaliplatin: no clinically significant differences in exposure to capecitabine or its metabolites, free platinum or total platinum occurred when capecitabine was administered in combination with oxaliplatin or in combination with oxaliplatin and bevacizumab.
Danish: Oxaliplatin: Der optrådte ingen klinisk betydende forskelle i eksponeringen for capecitabin eller dets metabolitter, frit platin eller total platin, når capecitabin blev administreret i kombination med oxaliplatin eller i kombination med oxaliplatin og bevacizumab.
English: 5-Fluorouracil: IV bolus injection immediately after leucovorin
Danish: bolus injektion umiddelbart efter leucovorin
English: In repeat-dose toxicity studies, daily oral administration of capecitabine to cynomolgus monkeys and mice produced toxic effects on the gastrointestinal, lymphoid and haemopoietic systems, typical for fluoropyrimidines.
Danish: I toksicitetsforsøg med gentagne doser førte dagligt oral administration af capecitabin til cynomolgusabe og mus til toksiske virkninger, typiske for fluoropyrimidiner, på det gastrointestinale, det lymfoide og det hæmatopoietiske system.
English: Capecitabine should only be prescribed by a doctor experienced in the use of anticancer medicines.
Danish: Capecitabin bør kun ordineres af en læge med erfaring i anvendelsen af lægemidler mod kræft.
English: Toxicity due to capecitabine administration may be managed by symptomatic treatment and/or modification of the dose (treatment interruption or dose reduction).
Danish: Toksicitet, som skyldes administration af capecitabin, kan behandles symptomatisk og/eller med modifikation af Capecitabin-dosis (afbrydelse af behandlingen eller reduktion af dosis).
English: (neuropathy) - have calcium imbalances (seen in blood tests) - have diabetes - cannot keep food or water in your body because of severe nausea and vomiting - have diarrhoea - are, or become dehydrated - have imbalances of ions in your blood (electrolyte imbalances, seen in tests) - have a history of eye problems as you may need extra monitoring of your eyes - have a severe skin reaction.
Danish: (neuropati) - har kalk-ubalance (ses i blodprøver) - har diabetes - ikke kan holde mad eller vand i kroppen pga. svær kvalme og opkastning - har diarré - er eller bliver dehydreret - har ionforstyrrelser i blodet (elektrolytubalance ses i blodprøver) - tidligere har haft problemer med øjnene, da du herved kan have brug for ekstra kontrol af dine øjne - har en alvorlig hudreaktion.
English: Coumarin-derivative anticoagulants: altered coagulation parameters and/or bleeding have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon.
Danish: Antikoagulantia af coumarintypen: der er rapporteret om ændrede koagulationsparametre og/eller ændret blødning hos patienter som tog capecitabin sammen med antikoagulantia af coumarintypen såsom warfarin og phenprocoumon.
English: Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. Do not store above 25°C.
Danish: Brug ikke lægemidlet efter den udløbsdato, der står på pakningen (efter EXP).
English: Antacid: the effect of an aluminium hydroxide and magnesium hydroxide-containing antacid on the pharmacokinetics of capecitabine was investigated.
Danish: Antacida: man har undersøgt virkningen af et antacidum indeholdende aluminiumhydroxid og magnesiumhydroxid på capecitabins farmakokinetik.
English: Folinic acid/folic acid: a combination study with capecitabine and folinic acid indicated that folinic acid has no major effect on the pharmacokinetics of capecitabine and its metabolites.
Danish: Folinsyre/folsyre: et studie om kombination af capecitabin og folinsyre tyder på, at folinsyre ikke har væsentlig effekt på farmakokinetikken af capecitabin og dets metabolitter.
English: Table 9 Key efficacy results for the non-inferiority analysis of study NO16967
Danish: Tabel 9 Nøgleresultater fra non-inferioritetsanalyserne af studie NO16967
English: + For each term, the frequency count was based on ADRs of all grades.
Danish: + For hver term er hyppigheden baseret på bivirkninger af alle grader.
English: - In patients with known dihydropyrimidine dehydrogenase (DPD) deficiency (see section 4.4).
Danish: - Patienter med kendt dihydropyrimidindehydrogenase- (DPD-) mangel (se pkt.
English: You need to be particularly careful if you are taking any of the following: - gout medicines (allopurinol) - blood-thinning medicines (coumarin, warfarin) - certain anti-viral medicines (sorivudine and brivudine) - medicines for seizures or tremors (phenytoin) - a medicine to treat cancer (interferon alpha) - radiotherapy and certain medicines used to treat cancer (folinic acid, oxaliplatin, bevacizumab,
Danish: Du skal være særlig forsigtig, hvis du tager: - medicin mod urinsyregigt (allopurinol) - blodfortyndende medicin (coumarin, warfarin) - visse anti-virusmidler (sorivudin og brivudin) eller - medicin mod kramper eller rystelser (phenytoin) - medicin til behandling af kræft (interferon alfa) - strålebehandling og visse lægemidler til behandling af kræft (folinsyre, oxaliplatin, bevacizumab,
English: What Capecitabine SUN contains - The active substance is capecitabine.
Danish: Capecitabin SUN indeholder: - Det aktive stof er capecitabin.
English: PRIMARY ANALYSIS XELOX/XELOX+P/ XELOX+BV (EPP*: N=967; ITT**: N=1017)
Danish: XELOX/XELOX+P/ XELOX+BV (EPP*: N=967; ITT**: N=1017)
English: There is some evidence that dexpanthenol is effective for hand-foot syndrome prophylaxis in patients treated with capecitabine.
Danish: Der er nogen evidens for, at dexpanthenol er virksomt som profylakse mod hånd- og fodsyndrom hos patienter, der behandles med capecitabin.
English: Parameter: Overall Survival EPP ITT *EPP=eligible patient population; **ITT=intent-to-treat population
Danish: *EPP=egnet patientpopulation; **ITT=intent-to-treat population
English: A person whose body weight is 80 kg and height is 1.80 m has a body surface area of 2.00 m2
Danish: En person, som vejer 80 kg, og som er 1,80 m høj, har et legemsoverfladeareal på 2,00 m2 og skal tage
English: If you have an unrecognised DPD deficiency and take Capecitabine SUN, you may experience severe forms of the side effects listed under section 4 Possible side effects.
Danish: Hvis du har DPD-mangel uden at vide det og tager Capecitabin SUN, kan du få bivirkningerne, anført i punkt 4 Bivirkninger, i svær form.
English: ADRs considered by the investigator to be possibly, probably, or remotely related to the administration of capecitabine are listed in table 4 for capecitabine given as a monotherapy and in table 5 for capecitabine given in combination with different chemotherapy regimens in multiple indications.
Danish: De bivirkninger, der af den behandlende investigator blev vurderet som muligvis, sandsynligvis eller tvivlsomt relateret til administrationen af capecitabin er angivet i tabel 4 for capecitabin-monoterapi og i tabel 5 for capecitabin givet i kombination med forskellige kemoterapiregimer indenfor flere indikationer.
English: Uncommon side effects (may affect up to 1 in 100 people) include: - blood infection, urinary tract infection, infection of the skin, infections in the nose and throat,
Danish: Ikke almindelige bivirkninger (kan påvirke op til 1 ud af 100 personer): - betændelse i blodet, urinvejsinfektion, betændelse i huden, næse- og halsinfektioner, svamp
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency: http://www.ema.europa.eu.
Danish: DATO FOR ÆNDRING AF TEKSTEN Yderligere oplysninger om dette lægemiddel findes på Det Europæiske Lægemiddelagenturs hjemmeside http://www.ema.europa.eu.
English: +Neutropenia, +Leucopenia, +Anaemia, +Neutropenic fever, Thrombocytopenia
Danish: +Neutropeni, +leukopeni, +anæmi, +neutropenisk feber, trombocytopeni
English: Capecitabine SUN with food and drink You should take Capecitabine SUN no later than 30 minutes after meals.
Danish: Brug af Capecitabin SUN med mad, drikke og alkohol Du skal tage Capecitabin SUN senest 30 minutter efter et måltid.
English: Coumarin-derivative anticoagulation.
Danish: Antikoagulantia af coumarintypen.
English: Cardiotoxicity has been associated with fluoropyrimidine therapy, including myocardial infarction, angina, dysrhythmias, cardiogenic shock, sudden death and electrocardiographic changes (including very rare cases of QT prolongation).
Danish: Fluoropyrimidinterapi har været ledsaget af kardiotoksicitet, inklusive myokardieinfarkt, angina pectoris, dysrytmier, kardiogent shock, pludselig død og ekg-ændringer (herunder meget sjældne tilfælde af QT-forlængelse).
English: Patients treated with XELIRI + bevacizumab reported a significantly higher incidence of diarrhoea, febrile neutropenia and hand-foot skin reactions than patients treated with FOLFIRI + bevacizumab with significantly increased treatment delays, dose reductions and treatment discontinuations.
Danish: XELIRI plus bevacizumab rapporterede signifikant højere incidenser af diarré, febril neutropeni og hånd-fod-hudreaktioner end patienter behandlet med FOLFIRI plus bevacizumab med signifikant højere frekevens af forsinkelse i behandling, dosisreduktioner og seponering af behandling.
English: Interferon alpha: the MTD of capecitabine was 2000 mg/m2 per day when combined with interferon alpha-2a (3 MIU/m2 per day) compared to 3000 mg/m2 per day when capecitabine was used alone.
Danish: Interferon-alfa: Capecitabins MTD var 2.000 mg/m2/dag, når det kombineredes med interferon alfa-2a (3 MIE/m2/dag) sammenlignet med 3.000 mg/m2/dag, når capecitabin blev givet alene.
English: Hand-foot syndrome (also known as hand-foot skin reaction or palmar-plantar erythrodysesthesia or chemotherapy induced acral erythema).
Danish: Hånd- og fodsyndrom (også kendt som hånd- og fodhudreaktion, palmoplantar erytrodysæstesi eller kemoterapiinduceret akralt erytem).
English: - In patients with severe renal impairment (creatinine clearance below 30 ml/min).
Danish: - Patienter med svær nyreinsufficiens (creatininclearance under 30 ml/min).
English: 5-fluorouracil IV bolus/infusion, each on Days 1 and 2, every 2 weeks
Danish: bolus/infusion, hver på dag 1 og 2, hver 2. uge
English: - During pregnancy and lactation.
Danish: - Graviditet og amning.
English: In patients with mild renal impairment (creatinine clearance 51-80 ml/min at baseline) no adjustment of the starting dose is recommended.
Danish: Til patienter med let nedsat nyrefunktion (creatininclearance 51 - 80 ml/min ved baseline) er dosisjustering ikke nødvendig.
English: Yellow iron oxide (E172) and red iron oxide (E172).
Danish: Gul jernoxid (E172) og rød jernoxid (E172).
English: Cytochrome P-450 2C9 substrates: Other than warfarin, no formal drug-drug interaction studies between capecitabine and other CYP2C9 substrates have been conducted.
Danish: CYP2C9-substrater: Der er ikke gennemført formelle lægemiddelinteraktionsstudier med capecitabin og andre CYP2C9-substrater bortset fra warfarin.
English: - Steven-Johnson syndrome: if you experience painful red or purplish rash that spreads and blisters and/or other lesions begin to appear in the mucous membrane (e.g. mouth and lips), in particular if you had before light sensitivity, infections of the respiratory system (e.g. bronchitis) and/or fever.
Danish: - Stevens-Johnsons syndrom: hvis du oplever smertefuldt rødt eller lilla udslæt, der spreder sig og danner blistre og/eller andre læsioner, der opstår i slimhinderne (fx mund eller læber), især hvis du tidligere har været følsom over for lys, haft infektioner i luftvejene (fx bronkitis)
English: Cardiovascular toxicity (e.g. PR- and QT-interval prolongation) was detectable in cynomolgus monkeys after intravenous administration (100 mg/kg) but not after repeated oral dosing (1379 mg/m2/day).
Danish: Der blev set kardiovaskulær toksicitet (f.eks. forlængelse af PR- og QT-intervallet) hos cynomolgusabe efter intravenøs administration (100 mg/kg), men ikke efter gentagen oral dosering (1379 mg/m2/dag)
English: Careful monitoring and prompt treatment interruption is recommended if the patient develops a grade 2, 3 or 4 adverse event during treatment and subsequent dose adjustment as outlined in table 3 above.
Danish: Hvis patienterne under behandlingen får uønskede hændelser af grad 2, 3 eller 4 tilrådes omhyggelig overvågning og øjeblikkelig afbrydelse af behandlingen med efterfølgende dosisjustering som beskrevet i tabel 3 ovenover.
English: Febrile neutropenia, Pancytopenia, Granulocytopenia, Thrombocytopenia, Leukopenia, Haemolytic anaemia, International Normalised Ratio (INR) increased/Prothrombin time prolonged
Danish: Febril neutropeni, Pancytopeni, Granulocytopeni, Thrombocytopeni, Leukopeni, Hæmolytisk anæmi, Øget international normaliseret ratio (INR)/forlænget protrombintid
English: Alu/Alu blister containing 10 film-coated tablets.
Danish: Aluminium/aluminium blistere indeholdende 10 filmovertrukne tabletter.
English: Do not drive if you feel dizzy, nauseous or tired after taking this medicine.
Danish: Du må ikke føre motorkøretøj, hvis du efter indtagelsen føler dig svimmel, har kvalme eller er træt.
English: If grade 2 or 3 hand- foot syndrome occurs, administration of capecitabine should be interrupted until the event resolves or decreases in intensity to grade 1.
Danish: Hvis der optræder grad 2 eller 3 hånd- og fodsyndrom skal behandlingen med capecitabin afbrydes indtil symptomerne forsvinder eller er aftaget i intensitet til grad 1.
English: Table 5 Summary of related ADRs reported in patients treated with capecitabine in combination treatment in addition to those seen with capecitabine monotherapy or seen at a higher frequency grouping compared to capecitabine monotherapy Body System Very common
Danish: Tabel 5 Sammenfatning af relaterede bivirkninger, som blev rapporteret hos patienter, der blev behandlet med capecitabin i kombinationsbehandling set ud over bivirkninger efter behandling med capecitabin-monoterapi eller set i en højere frekvensgruppe sammenlignet med capecitabin-monoterapi
English: The pharmacokinetics of capecitabine have been evaluated over a dose range of 502-3514 mg/m2/day.
Danish: Capecitabins farmakokinetik er undersøgt i dosisintervallet 502 - 3514 mg/m2/dag.
English: - In patients with severe hepatic impairment.
Danish: - Patienter med svær leverinsufficiens.
English: Cardiotoxicity.
Danish: Kardiotoksicitet.
English: Sorivudine and analogues: a clinically significant drug-drug interaction between sorivudine and 5-FU, resulting from the inhibition of dihydropyrimidine dehydrogenase by sorivudine, has been described.
Danish: Sorivudin og analoger: der er beskrevet en klinisk signifikant interaktion mellem de to lægemidler, sorivudine og 5-FU, som et resultat af sorivudines hæmning af dihydropyrimidindehydrogenase.
English: Capecitabine SUN tablets should be swallowed whole with water, and within 30 minutes of a meal.
Danish: Capecitabin SUN-tabletter skal sluges hele med vand, og senest 30 minutter efter et måltid.
English: Capecitabine is also indicated as monotherapy for the treatment of patients with locally advanced or metastatic breast cancer after failure of taxanes and an anthracycline-containing chemotherapy regimen or for whom further anthracycline therapy is not indicated.
Danish: Capecitabin er også indiceret som monoterapi til behandling af patienter med lokal fremskreden eller metastatisk brystkræft efter svigt af taxoider og et kemoterapiregime indeholdende et anthracyklin eller hos hvem anthracyklin-behandling ikke er indiceret.
English: Patients taking coumarinderivative anticoagulants concomitantly with capecitabine should be monitored regularly for alterations in their coagulation parameters (PT or INR) and the anti-coagulant dose adjusted accordingly.
Danish: Patienter som tager antikoagulantia af coumarintypen sammen med capecitabin skal kontrolleres regelmæssigt mht. ændringer i deres koagulationsparametre (PT eller INR), og antikoagulansdosis skal om nødvendigt justeres.
English: Therefore, capecitabine must not be administered concomitantly with sorivudine or its chemically related analogues, such as brivudine (see section 4.3).
Danish: Capecitabin må derfor ikke administreres sammen med sorivudin eller kemisk beslægtede stoffer, såsom brivudin (se pkt.
English: Parameter: Progression-free Survival PPP ITT Parameter: Overall Survival PPP ITT *PPP=per-protocol population; **ITT=intent-to-treat population
Danish: Parameter: Samlet overlevelse PPP ITT *PPP=per protokol population; **ITT=intent-to-treat population
English: - Treatment with sorivudine or its chemically related analogues, such as brivudine (see section 4.5).
Danish: - Behandling med sorivudin eller kemisk beslægtede stoffer, såsom brivudin (se pkt.
English: Bevacizumab: there was no clinically significant effect of bevacizumab on the pharmacokinetic parameters of capecitabine or its metabolites in the presence of oxaliplatin.
Danish: Bevacizumab: Bevacizumab havde ingen klinisk signifikant virkning på capecitabins farmakokinetiske parametre eller dets metabolitter under tilstedeværelse af oxaliplatin.
English: 5 mg/kg IV 30-90 mins Day 1, prior to FOLFOX-4, every 2 weeks
Danish: 30-90 min. Dag 1, før FOLFOX-4, hver 2. uge
English: Capecitabine SUN contains anhydrous lactose This medicine contains anhydrous lactose.
Danish: Capecitabin SUN indeholder lactose, hvor advarsel er påkrævet Dette lægemiddel indeholder lactose.
English: Do not take the missed dose at all and do not double the next one.
Danish: Du må ikke tage den glemte dosis, og du må ikke tage en dobbeldosis som erstatning for den glemte dosis.
English: PHARMACEUTICAL FORM AND CONTENTS 120 film-coated tablets
Danish: LÆGEMIDDELFORM OG INHOLD (PAKNINGSSTØRRELSE) 120 filmovertrukne tabletter.
English: Time to progressive disease was superior in the capecitabine + docetaxel combination arm (p<0.0001).
Danish: Tid indtil progressiv sygdom var længere i kombinationsarmen med Capecitabin + docetaxel (p < 0,0001).
English: Capecitabine is indicated for the adjuvant treatment of patients following surgery of stage III (Dukes' stage C) colon cancer (see section 5.1).
Danish: Capecitabin er indiceret som adjuverende behandling af patienter, som er opereret for stadium III (Dukes stadium C) kolonkræft (se pkt.
English: Angina unstable, Angina pectoris, Myocardial ischaemia, Atrial fibrillation, Arrhythmia, Tachycardia, Sinus tachycardia, Palpitations
Danish: Ustabil angina, Angina pectoris, Myokardiel iskæmi, Atrieflimmer, Arytmi, Takykardi, Sinus takykardi, Palpitationer
English: Rare side effects (may affect up to 1 in 1,000 people) include: - narrowing or blockage of tear duct (lacrimal duct stenosis) - liver failure - inflammation leading to dysfunction or obstruction in bile secretion (cholestatic hepatitis) - specific changes in the electrocardiogram (QT prolongation)
Danish: Sjældne bivirkninger (kan påvirke op til 1 ud af 1.000 personer): - forsnævring eller blokering af tårekanalen, - leversvigt, - betændelse der medfører, at kroppens udskillelse af galde nedsættes eller ophører (kolestatisk hepatitis), - bestemte ændringer i EKG'et (QT-forlængelse),
English: - certain types of arrhythmia (including ventricular fibrillation, torsade de pointes, and bradycardia) - eye inflammation causing eye pain and possibly eyesight problems - inflammation of the skin causing red scaly patches due to an immune system illness.
Danish: - bestemte former for forstyrrelser i hjerterytmen (ventrikelflimren, torsades de pointes og bradykardi), - inflammation i øjet, der medfører smerter i øjet og muligvis problemer med synet, - inflammation i huden, der medfører røde skællende pletter på grund af en sygdom i immunsystemet.
English: keratitis (rare)
Danish: Ventrikelflimmer (sjælden),
English: Capecitabine is indicated for first-line treatment of advanced gastric cancer in combination with a platinum-based regimen (see section 5.1).
Danish: Capecitabin er indiceret til 1. linjebehandling af fremskreden ventrikelkræft i kombination med et platinbaseret regime (se pkt.
English: In case you are using coumarin anticoagulants (containing e.g. phenprocoumon), stopping Capecitabine SUN might require that your doctor adjusts your anticoagulant dose.
Danish: Hvis du bruger blodfortyndende medicin af coumarintypen (indeholdende f.eks. phenprocoumon), kan det blive nødvendigt, at din læge ændrer dosis af denne medicin, hvis behandlingen med Capecitabin SUN stopper.
English: Pulmonary embolism, Pneumothorax, Haemoptysis, Asthma, Dyspnoea exertional
Danish: Pulmonær emboli, Pneumothorax, Hæmoptyse, Asthma, Funktionsdyspnø
English: The European Medicines Agency has waived the obligation to conduct studies with the reference medicinal product containing capecitabine in all subsets of the paediatric population in adenocarcinoma of the colon and rectum, gastric adenocarcinoma and breast carcinoma (see section 4.2 for information on paediatric use).
Danish: Det Europæiske Lægemiddelagentur har dispenseret fra kravet om at fremlægge resultaterne af studier med referencelægemidlet, som indeholder capecitabin, i alle undergrupper af den pædiatriske population med adenokarcinom i colon og rektum, ventrikeladenokarcinom og brystkarcinom (se pkt.
English: Day 1, prior to XELOX, every 3 weeks
Danish: 30-90 min Dag 1, før XELOX, hver 3. uge
English: Parameter: Progression-free Survival PPP ITT Parameter: Overall Survival PPP ITT
Danish: Parameter: Progressionsfri overlevelse PPP ITT Parameter: Samlet overlevelse PPP ITT
English: Grade 3 hand- foot syndrome is moist desquamation, ulceration, blistering and severe pain of the hands and/or feet and/or severe discomfort that causes the patient to be unable to work or perform activities of daily living.
Danish: Grad 3 hånd- og fodsyndrom defineres som fugtig afskalning, ulceration, blisterdannelse og svær smerte af hænderne og/eller fødderne og/eller svært ubehag der forårsager at patienten ikke kan passe sit arbejde og er ude af stand til at udføre daglige aktiviteter.
English: Capecitabine is indicated for the treatment of metastatic colorectal cancer (see section 5.1).
Danish: Capecitabin er indiceret til behandling af metastatisk kolorektalkræft (se pkt.
English: Blister, Skin ulcer, Rash, Urticaria, Photosensitivity reaction, Palmar erythema, Swelling face, Purpura, Radiation recall syndrome
Danish: Blister, Sår i huden, Udslæt, Urticaria, Fotosensitivitetsreaktioner, Palmart erythem, Hævelse i ansigtet, Purpura, Radiation recall syndrom
English: Cutaneous lupus erythematosus (rare), Severe skin reactions such as Steven-Johnson Syndrome and toxic Epidermal Necrolysis (very rare) (see section
Danish: Kutan lupus erythematosus (sjælden), Alvorlige hudreaktioner såsom StevensJohnsons syndrom og toksisk epidermal nekrolyse (meget sjælden) (se pkt.