FrancophonIA/ELRC3.0 huggingface dataset:
English: Caution should be exercised when switching combination therapy from ciclosporin, which interferes with enterohepatic recirculation of mycophenolic acid, to tacrolimus, which is devoid of this effect, as this might result in changes of mycophenolic acid exposure.
Slovenian: Mikofenolna kislina; previdnost je potrebna pri prehodu s kombiniranega zdravljenja s ciklosporinom, ki ovira enterohepatično kroženje mikofenolne kisline, na takrolimus, ki tega učinka nima, kajti takšen prehod lahko spremeni izpostavljenost mikofenolni kislini.
English: What you need to know before you take Modigraf Do not take Modigraf
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Modigraf
English: Conversion between Modigraf and Prograf tacrolimus formulations In healthy subjects the systemic exposure to tacrolimus (AUC) for Modigraf was approximately 18% higher than that for Prograf capsules when administered as single doses.
Slovenian: Prehod med farmacevtskima oblikama s takrolimusom v zdravilu Modigraf in zdravilu Prograf Pri zdravih ljudeh je sistemska izpostavljenost takrolimusu (AUC) približno za 18 % višja po enkratnem odmerku pri zdravilu Modigraf v primerjavi s kapsulami Prograf.
English: Following the initiation of your treatment with Modigraf, frequent blood tests will be taken by your doctor to define the correct dose and to adjust the dose from time to time.
Slovenian: Po uvedbi zdravljenja z zdravilom Modigraf bo zdravnik pogosto opravljal krvne preiskave in tako določil ustrezen odmerek in ga po potrebi prilagodil.
English: After oral administration (0.30 mg/kg/day) to paediatric liver transplant patients, steady-state concentrations of tacrolimus were achieved within 3 days in the majority of patients.
Slovenian: Po peroralni uporabi (0,30 mg/kg/dan) pri pediatričnih bolnikih z jetrnim presadkom, so bile koncentracije dinamičnega ravnovesja pri večini bolnikov dosežene v treh dneh.
English: In current clinical practice, whole blood levels are monitored using immunoassay methods.
Slovenian: V klinični praksi se za nadziranje koncentracije v polni krvi trenutno uporabljajo imunske metode.
English: The most commonly reported adverse reactions (occurring in > 10% of patients) are tremor, renal impairment, hyperglycaemic conditions, diabetes mellitus, hyperkalaemia, infections, hypertension and insomnia.
Slovenian: Najpogosteje (pri > 10 % bolnikov) so poročali o neželenih učinkih, kot so tremor, okvara ledvic, hiperglikemična stanja, diabetes mellitus, hiperkaliemija, okužbe, hipertenzija in nespečnost.
English: Modigraf granules contain lactose.
Slovenian: Zrnca Modigraf vsebujejo laktozo.
English: The combined administration of ciclosporin and tacrolimus is not recommended.
Slovenian: Sočasno zdravljenje s ciklosporinom in takrolimusom ni priporočljivo.
English: All patients reported risk factors for PRCA such as parvovirus B19 infection, underlying disease or concomitant medications associated with PRCA.
Slovenian: Pri vseh bolnikih so bili prisotni dejavniki tveganja za čisto aplazijo eritrocitov, kot so okužba s parvovirusom B19, druga bolezen ali sočasno jemanje zdravil, povezanih s PRCA.
English: acute and chronic pancreatitis, ileus paralytic, gastrooesophageal reflux disease, impaired gastric emptying rare:
Slovenian: akutni in kronični pankreatitis, paralitični ileus, gastroezofagealna refluksna bolezen, okvarjeno praznjenje želodca redki:
English: Maintenance doses of corticosteroids have been shown to reduce tacrolimus blood levels.
Slovenian: Dokazano je, da vzdrževalni odmerki kortikosteroidov znižajo koncentracijo takrolimusa v krvi.
English: In an additional 2-centre study, 26 patients were randomised to the tacrolimus versus 24 patients to the ciclosporin group.
Slovenian: V dodatni študiji v dveh centrih so 26 bolnikov randomizirali na takrolimus in 24 na ciklosporin.
English: Medication errors, including inadvertent, unintentional or unsupervised substitution of immediate- or prolonged-release tacrolimus formulations, have been observed.
Slovenian: Opazili so napake pri uporabi zdravila, vključno z nepazljivim, nenamernim ali nenadzorovanim zamenjevanjem zdravil s takrolimusom v farmacevtskih oblikah s takojšnjim ali podaljšanim sproščanjem.
English: Modigraf should not be switched with Advagraf as a clinically relevant difference in bioavailability between the two formulations cannot be excluded.
Slovenian: Zdravila Modigraf ne smemo zamenjati z zdravilom Advagraf, ker ne moremo izključiti klinično pomembne razlike v biološki uporabnosti med zdraviloma.
English: C. OTHER CONDITIONS AND REQUIREMENT OF THE MARKETING AUTHORISATION
Slovenian: C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
English: In adult and paediatric liver transplant patients, it averaged 11.7 hours and 12.4 hours, respectively, compared with 15.6 hours in adult kidney transplant recipients.
Slovenian: Pri odraslih bolnikih s presajenimi jetri je bil povprečni razpolovni čas 11,7 ur in pri pediatričnih bolnikih 12,4 ure.
English: Patients treated with immunosuppressants, including Modigraf, are at increased risk for infections including opportunistic infections (bacterial, fungal, viral and protozoal) such as BK virus associated nephropathy and JC virus associated progressive multifocal leukoencephalopathy (PML).
Slovenian: Pri bolnikih, ki se zdravijo z zdravili za zaviranje imunske odzivnosti, vključno z zdravilom Modigraf, obstaja večje tveganje za pojav okužb, vključno z oportunističnimi okužbami (bakterijskimi, glivičnimi, virusnimi in protozojskimi), kot sta z virusom BK povezana nefropatija in z virusom JC povezana progresivna multifokalna levkoencefalopatija (PML).
English: fall, ulcer, chest tightness, thirst very rare:
Slovenian: padec, razjeda, tiščanje v prsih, žeja zelo redki:
English: In isolated patients with very high plasma levels, haemofiltration or -diafiltration have been effective in reducing toxic concentrations.
Slovenian: Pri posameznih bolnikih z zelo visoko koncentracijo v plazmi sta toksične koncentracije učinkovito znižali hemofiltracija ali hemodiafiltracija.
English: Stable allograft recipients maintained on Modigraf granules, requiring conversion to Prograf capsules, should be converted on a 1:1 mg:mg total daily dose basis.
Slovenian: Stabilni prejemniki alogenskih presadkov, ki se zdravijo z zrnci Modigraf in potrebujejo zamenjavo zdravila s kapsulami Prograf, je zamenjavo potrebno izvesti tako, da ostane skupni dnevni odmerek zdravila nespremenjen (1 : 1 (mg : mg)).
English: CYP3A4 inducers potentially leading to decreased tacrolimus blood levels Clinically the following substances have been shown to decrease tacrolimus blood levels: Strong interactions have been observed with rifampicin, phenytoin or St. John's Wort (Hypericum perforatum) which may require increased tacrolimus doses in almost all patients.
Slovenian: Induktorji CYP3A4, ki lahko vodijo do znižanih vrednosti takrolimusa v krvi Klinično je ugotovljeno, da koncentracijo takrolimusa v krvi znižujejo naslednje snovi: Močne interakcije so opazili z rifampicinom, fenitoinom in šentjanževko (Hypericum perforatum), zato je treba v takšnem primeru odmerek takrolimusa skoraj pri vseh bolnikih povečati.
English: Concomitant use of substances known to inhibit or induce CYP3A4 may affect the metabolism of tacrolimus and thereby increase or decrease tacrolimus blood levels.
Slovenian: Sočasna uporaba učinkovin, ki zavirajo ali inducirajo CYP3A4, lahko vpliva na presnovo takrolimusa in poviša ali zniža njegovo koncentracijo v krvi.
English: You should generally take Modigraf on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal.
Slovenian: Zdravilo Modigraf je praviloma treba jemati na prazen želodec ali vsaj 1 uro pred ali 2 do 3 ure po jedi.
English: venoocclusive liver disease, hepatic artery thrombosis very rare:
Slovenian: venookluzivna bolezen jeter, tromboza jetrne arterije zelo redki:
English: Possible interactions with other medicinal products known to have high affinity for plasma proteins should be considered (e.g., NSAIDs, oral anticoagulants, or oral antidiabetics).
Slovenian: Upoštevati je treba možnost medsebojnega delovanja z drugimi zdravili, za katere je znano, da imajo veliko afiniteto za beljakovine v plazmi (npr. nesteroidna protivnetna zdravila, peroralni antikoagulanti ali peroralni antidiabetiki).
English: encephalopathy, central nervous system haemorrhages and cerebrovascular accidents, coma, speech and language abnormalities, paralysis and paresis, amnesia rare:
Slovenian: encefalopatija, krvavitve v osrednje živčevje in cerebrovaskularni incidenti, koma, motnje govora in jezika, paraliza in pareza, amnezija redki:
English: Mechanism of action and pharmacodynamic effects At the molecular level, the effects of tacrolimus appear to be mediated by binding to a cytosolic protein (FKBP12) which is responsible for the intracellular accumulation of the compound.
Slovenian: Kaže, da učinke takrolimusa na molekulski ravni sproži vezava na citosolno beljakovino (FKBP12), ki je odgovorna za njegovo znotrajcelično kopičenje.
English: In vitro the following substances have been shown to be potential inhibitors of tacrolimus metabolism: bromocriptine, cortisone, dapsone, ergotamine, gestodene, lidocaine, mephenytoin, miconazole, midazolam, nilvadipine, norethisterone, quinidine, tamoxifen, troleandomycin.
Slovenian: In vitro so se kot možni zaviralci presnove takrolimusa izkazale naslednje snovi: bromokriptin, kortizon, dapson, ergotamin, gestoden, lidokain, mefenitoin, mikonazol, midazolam, nilvadipin, noretisteron, kinidin, tamoksifen, troleandomicin.
English: There are no safety data available on the use of Modigraf granules following a temporary switch from Prograf or Advagraf in critically ill patients.
Slovenian: Pri kritično bolnih ni na voljo podatkov o varnosti uporabe granul zdravila Modigraf po začasnem prehodu z zdravila Prograf ali zdravila Advagraf.
English: Astellas Pharma Kft. Tel.: + 36 1 577 8200
Slovenian: Magyarország Astellas Pharma Kft. Tel.: + 36 1 577 8200
English: In comparison to Caucasians, black patients may require higher tacrolimus doses to achieve similar trough levels.
Slovenian: Pri bolnikih črne rase bodo za dosego enakih najnižjih koncentracij morda potrebni višji odmerki takrolimusa kot pri bolnikih kavkazijskega porekla.
English: Blood trough levels of tacrolimus should also be closely monitored when clinical signs of toxicity or acute rejection are observed, following conversion between Modigraf granules to Prograf capsules, dose adjustments, changes in the immunosuppressive regimen, or co-administration of substances which may alter tacrolimus whole blood concentrations (see section 4.5).
Slovenian: Najnižje koncentracije takrolimusa v krvi je treba skrbno nadzirati tudi, ko se pojavijo klinični znaki toksičnosti ali akutne zavrnitve, po zamenjavi zrnc Modigraf s kapsulami Prograf, prilagoditvah odmerka, spremembah imunosupresivnega režima ali ob sočasni uporabi učinkovin, ki lahko spremenijo koncentracije takrolimusa v polni krvi (glejte poglavje 4.5).
English: Highly variable age dependent total body clearance and half life were observed in limited paediatric clinical investigations, especially in early childhood.
Slovenian: Pri majhnem številu kliničnih raziskav so se pokazale velike razlike v celokupnem telesnem očistku in razpolovnem času v odvisnosti od starosti, še posebej če je šlo za obdobje zgodnjega otroštva.
English: Psychiatric disorders very common:
Slovenian: Psihiatrične motnje zelo pogosti:
English: heart failures, ventricular arrhythmias and cardiac arrest, supraventricular arrhythmias, cardiomyopathies, ventricular hypertrophy, palpitations rare:
Slovenian: srčno popuščanje, ventrikularne aritmije in zastoji srca, supraventrikularne aritmije, kardiomiopatije, ventrikularna hipertrofija, palpitacije redki:
English: As is well known for other potent immunosuppressive agents, patients receiving tacrolimus are frequently at increased risk for infections (viral, bacterial, fungal, protozoal).
Slovenian: Tako kot med zdravljenjem z drugimi močnimi imunosupresivi bolnike tudi med zdravljenjem s takrolimusom pogosto bolj ogrožajo okužbe (virusne, bakterijske, glivične, protozojske).
English: Tacrolimus therapy is generally initiated by the oral route.
Slovenian: Zdravljenje s takrolimusom se praviloma začne peroralno.
English: The 1-year survival rates were 73.1% in the tacrolimus versus 79.2% in the ciclosporin group.
Slovenian: Enoletno preživetje v skupini s takrolimusom je bilo 73,1 % in v skupini s ciklosporinom 79,2 %.
English: When substances with a potential for interaction (see section 4.5) - particularly strong inhibitors of CYP3A4 (such as telaprevir, boceprevir, ritonavir, ketoconazole, voriconazole, itraconazole, telithromycin or clarithromycin) or inducers of CYP3A4 (such as rifampicin, rifabutin) - are being combined with tacrolimus, tacrolimus blood levels should be monitored to adjust the tacrolimus dose as appropriate in order to maintain similar tacrolimus exposure.
Slovenian: Pri sočasni uporabi učinkovin, pri katerih je možno medsebojno delovanje (glejte poglavje 4.5) - še posebej močnih inhibitorjev CYP3A4 (kot so telaprevir, boceprevir, ritonavir, ketokonazol, vorikonazol, itrakonazol, telitromicin ali klaritromicin) ali induktorjev CYP3A4 (kot so rifampicin, rifabutin) - s takrolimusom, je treba spremljati koncentracije takrolimusa v krvi in ustrezno prilagoditi odmerek takrolimusa, da se zagotovi vzdrževanje nespremenjene izpostavljenosti takrolimusu.
English: haemolytic uraemic syndrome, anuria very rare:
Slovenian: hemolitično-uremični sindrom, anurija zelo redki:
English: Hypersensitivity to tacrolimus or to any of the excipients listed in section 6.1.
Slovenian: Preobčutljivost na takrolimus ali katerokoli pomožno snov (navedeno v poglavju 6.1).
English: metabolic acidoses, other electrolyte abnormalities, hyponatraemia, fluid overload, hyperuricaemia, hypomagnesaemia, hypokalaemia, hypocalcaemia, appetite decreased, hypercholesterolaemia, hyperlipidaemia, hypertriglyceridaemia, hypophosphataemia uncommon:
Slovenian: metabolična acidoza, druge nepravilnosti elektrolitov, hiponatriemija, preobremenitev s tekočino, hiperurikemija, hipomagneziemija, hipokaliemija, hipokalciemija, zmanjšanje apetita, hiperholesterolemija, hiperlipidemija, hipertrigliceridemija, hipofosfatemija občasni:
English: amylase increased, ECG investigations abnormal, heart rate and pulse investigations abnormal, weight decreased, blood lactate dehydrogenase increased very rare:
Slovenian: zvišanje amilaze, nenormalni izvidi preiskave EKG, nenormalni izvidi srčne frekvence in ritma, hujšanje, zvišanje laktat dehidrogenaze v krvi zelo redki:
English: In paediatric liver transplant patients the mean oral bioavailability of tacrolimus (investigated with the Modigraf granules) is 26%± 23% (individual range in paediatric liver transplant patients 4 - 80%).
Slovenian: Pri pediatričnih bolnikih s presajenimi jetri je bila srednja peroralna biološka uporabnost takrolimusa (raziskave so bile izvedene s farmacevtsko obliko zrnca Modigraf) 26 % ± 23 % (individualni razpon pri pediatričnih bolnikih s presajenimi jetri je bil 4 do 80 %).
English: Following intravenous and oral administration of 14C-labelled tacrolimus, most of the radioactivity was eliminated in the faeces.
Slovenian: C označenega takrolimusa se je večina radioaktivnosti izločila v blatu.
English: Other interactions which have led to clinically detrimental effects Concurrent use of tacrolimus with medicinal products known to have nephrotoxic or neurotoxic effects may increase these effects (e.g., aminoglycosides, gyrase inhibitors, vancomycin, sulfamethoxazole+trimethoprim, NSAIDs, ganciclovir or aciclovir).
Slovenian: Druge interakcije, ki povzročijo klinično škodljive učinke Te učinke lahko poveča sočasna uporaba takrolimusa in zdravil z nefrotoksičnimi ali nevrotoksičnimi učinki (kot so aminoglikozidi, zaviralci giraze, vankomicin, sulfametoksazol + trimetoprim, nesteroidna protivnetna zdravila, ganciklovir ali aciklovir).
English: Your doctor may need to adjust your dose of Modigraf.
Slovenian: Zdravnik vam bo, če bo potrebno, prilagodil odmerek zdravila Modigraf.
English: Prophylaxis of heart transplant rejection
Slovenian: Preprečevanje zavrnitve presadka pri presaditvi srca
English: Modigraf granules should generally be administered on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal, to achieve maximal absorption (see section 5.2).
Slovenian: Za dosego največje absorpcije je treba zdravilo zrnca Modigraf praviloma jemati na prazen želodec ali vsaj 1 uro pred ali 2 do 3 ure po jedi (glejte poglavje 5.2).
English: In man, tacrolimus has been shown to be able to be absorbed throughout the gastrointestinal tract.
Slovenian: Pri človeku je dokazano, da se takrolimus absorbira skozi celotna prebavila.
English: Mean oral bioavailability of tacrolimus (investigated with the Prograf capsules formulation) is in the range of 20 - 25% (individual range in adult patients 6 - 43%, in paediatric kidney transplant patients 3 - 77%).
Slovenian: Povprečna biološka uporabnost peroralno uporabljenega takrolimusa (raziskave so bile izvedene s farmacevtsko obliko Prograf) je od 20 do 25 % (individualni razpon pri odraslih bolnikih 6 do 43 %, pri pediatričnih bolnikih s presajenimi ledvicami pa 3 do 77 %).
English: A lower incidence of acute rejection episodes for tacrolimus- versus ciclosporin-treated patients (11.5% versus 22.6%) and a lower incidence of chronic rejection, the bronchiolitis obliterans syndrome (2.86% versus 8.57%), was reported within the first year after transplantation.
Slovenian: V prvem letu po presaditvi so imeli prejemniki takrolimusa manjšo incidenco akutnih zavrnitvenih epizod (11,5 %) in kronične zavrnitve, sindroma obliteracijskega bronhiolitisa (2,86 %), kot prejemniki ciklosporina, pri katerih sta bila ta deleža 22,6 % oz. 8,57 %.
English: influenza like illness, feeling jittery, feeling abnormal, multi-organ failure, chest pressure sensation, temperature intolerance rare:
Slovenian: gripi podobna bolezen, občutek živčnosti, nenormalno počutje, odpoved več organov, občutek tiščanja v prsih, intoleranca vročine redki:
English: Increased tacrolimus doses, supplemental corticosteroid therapy, and introduction of short courses of mono-/polyclonal antibodies have all been used to manage rejection episodes.
Slovenian: Za obvladanje zavrnitvenih epizod so uporabljali večje odmerke takrolimusa, dodatno zdravljenje s kortikosteroidi in uvedbo kratkih ciklusov mono-/poliklonskih protiteles.
English: As tacrolimus is a substance with low clearance, it may take several days after adjustments to the Modigraf dose regimen before steady state is achieved (see below under “Therapeutic drug monitoring” and section 5.2).
Slovenian: Ker je očistek takrolimusa majhen, lahko prilagajanje odmerka zdravila Modigraf za vzpostavitev stanja dinamičnega ravnovesja traja več dni (glejte spodaj “Spremljanje koncentracije zdravila” in poglavje 5.2).
English: Astellas Pharma s.r.o., Tel: +421 2 4444 2157
Slovenian: Slovenská republika Astellas Pharma s.r.o., Tel: +421 2 4444 2157
English: Caution should also be exercised in patients diagnosed or suspected to have Congenital Long QT Syndrome or acquired QT prolongation or patients on concomitant medications known to prolong the QT interval, induce electrolyte abnormalities or known to increase tacrolimus exposure (see section 4.5).
Slovenian: Previdnost je tudi potrebna pri bolnikih, ki imajo diagnosticiran ali pri njih obstaja sum na prirojen podaljšan QT sindrom, pri bolnikih, s pridobljenim podaljšanjem QT intervalom, ali bolnikih, ki sočasno jemljejo zdravila, ki podaljšujejo QT interval, izzovejo neravnovesje elektrolitov ali pa so znana, da vplivajo na izpostavljenost takrolimusu (glejte poglavje 4.5).
English: Treatment of allograft rejection after heart transplantation therapy - adults and paediatric patients In adult patients converted to Modigraf, an initial oral dose of 0.15 mg/kg/day should be administered in 2 divided doses (e.g. morning and evening).
Slovenian: Zdravljenje zavrnitve alogenskega presadka po presaditvi srca - odrasli in pediatrični bolniki Pri odraslih bolnikih je pri prehodu na zdravljenje z zdravilom Modigraf treba uvesti začetni peroralni odmerek 0,15 mg/kg/dan, ki se ga daje v dveh deljenih odmerkih (npr. zjutraj in zvečer).
English: Weaker interactions have been observed with clotrimazole, clarithromycin, josamycin, nifedipine, nicardipine, diltiazem, verapamil, amiodarone, danazol, ethinylestradiol, omeprazole, nefazodone and (Chinese) herbal remedies containing extracts of Schisandra sphenanthera.
Slovenian: Šibkejše interakcije so opazili pri sočasni uporabi s klotrimazolom, klaritromicinom, z josamicinom, nifedipinom, nikardipinom, diltiazemom, verapamilom, amiodaronom, danazolom, etinilestradiolom, omeprazolom, nefazodonom in (kitajskimi) zdravili rastlinskega izvora, ki vsebujejo izvlečke Schisandre sphenanthere.
English: It is strongly recommended to closely monitor tacrolimus blood levels, as well as, QT prolongation (with ECG), renal function and other side effects, whenever substances which have the potential to alter CYP3A4 metabolism or otherwise influence tacrolimus blood levels are used concomitantly, and to interrupt or adjust the tacrolimus dose as appropriate in order to maintain similar tacrolimus exposure (see sections 4.2 and 4.4).
Slovenian: Koncentracijo takrolimusa v krvi, kot tudi podaljšanje intervala QT (s pomočjo EKG), ledvično funkcijo in druge neželene učinke, je zelo priporočljivo skrbno nadzirati, kadarkoli se sočasno uporabljajo učinkovine, ki lahko spremenijo presnovo CYP3A4 ali ki drugače vplivajo na vrednosti takrolimusa v krvi, in odmerek takrolimusa prekiniti ali ustrezno prilagoditi, da bi izpostavljenost takrolimusu ohranili približno enako (glejte poglavji 4.2 in 4.4).
English: Prophylaxis of transplant rejection in adult and paediatric, kidney, liver or heart allograft recipients.
Slovenian: Preprečevanje zavrnitve presadka pri odraslih in otrocih po alogenski presaditvi ledvic, jeter ali srca.
English: Dosing should primarily be based on clinical assessments of rejection and tolerability in each individual patient aided by whole blood tacrolimus trough level monitoring.
Slovenian: Odmerjanje mora v prvi vrsti temeljiti na klinični oceni zavrnitve in prenašanja vsakega posameznega bolnika s pomočjo nadziranja najnižjih koncentracij takrolimusa v polni krvi.
English: Tacrolimus affected fertility in male rats (see section 5.3).
Slovenian: Takrolimus je pri podganjih samcih negativno vplival na plodnost (glejte poglavje 5.3).
English: pancreatic pseudocyst, subileus Hepatobiliary disorders common:
Slovenian: psevdocista pankreasa, subileus
English: A variety of innovations, such as techniques for early detection of Epstein-Barr (EBV) and CMV infections, bone marrow augmentation, the adjunct use of the interleukin-2 antagonist daclizumab, lower initial tacrolimus doses with target trough levels of 10 to 15 nanogram/ml, and most recently allograft irradiation were considered to have contributed to improved results in this indication over time.
Slovenian: Domnevno so k izboljšanju rezultatov skozi čas pri tej indikaciji pripomogle različne inovacije, npr. postopki za zgodnje odkrivanje okužb z virusom Epstein-Barr (EBV) in CMV, prirast kostnega mozga, dodatna uporaba antagonista interlevkina-2 daklizumaba, manjši začetni odmerki takrolimusa s ciljno najnižjo koncentracijo od 10 do 15 ng/ml in, v najnovejšem času, obsevanje alotransplantata.
English: Similarly, for conversion of patients from Prograf capsules to Modigraf granules, the total daily Modigraf dose should preferably be equal to the total daily Prograf dose.
Slovenian: Podobno naj bo pri zamenjavi kapsul Prograf z zrnci Modigraf skupni dnevni odmerek zrnc Modigraf po možnosti enak skupnemu dnevnemu odmerku kapsul Prograf.
English: It is recommended that the oral daily dose of Modigraf be administered in 2 divided doses (e.g. morning and evening).
Slovenian: Priporočeno je, da bolnik peroralni dnevni odmerek zdravila Modigraf vzame v dveh deljenih odmerkih (npr. zjutraj in zvečer).
English: Astellas Pharma Puh/Tel: + 358 (0)9 85606000
Slovenian: Suomi/Finland Astellas Pharma Puh/Tel: + 358 (0)9 85606000