FrancophonIA/ELRC3.0 huggingface dataset:
English: The CHMP noted that the suggested dose reductions for renal impairment at treatment of herpes labialis are somewhat different from that for other indications, since the dose is halved already at CLcrea 30-49 ml/min, despite the relatively low dose.
Slovenian: CHMP je ugotovil, da so predlagana zmanjšanja odmerkov za zdravljenje labialnega herpesa v primeru okvarjenega delovanja ledvic nekoliko drugačna kot pri drugih indikacijah, ker je odmerek razpolovljen že pri CLcrea 30-49 ml/min kljub relativno majhnem odmerku.
English: For AEs identified from clinical trials, a frequency category was assigned based on the overall frequency observed in clinical trials.
Slovenian: Neželenim pojavom, ugotovljenim v kliničnih preskušanjih, je bila kategorija pogostnosti dodeljena na osnovi celokupne pogostnosti, opažene v kliničnih preskušanjih.
English: More serious ARs such as thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome, acute renal failure and neurological disorders are discussed in greater detail in other sections of the label.
Slovenian: Resnejši neželeni učinki, npr. trombotična trombocitopenična purpura/hemolitično-uremični sindrom, akutna odpoved ledvic in nevrološke motnje, so podrobneje obravnavani v drugih poglavjih označevanja.
English: The CHMP asked the MAH to substantiate all proposed frequencies and to submit, with adequate supportive data, a revised section 4.8 in line with the SPC guideline.
Slovenian: CHMP je prosil imetnika dovoljenja za promet z zdravilom, da utemelji vse predlagane pogostnosti ter da z ustreznimi podpornimi podatki predloži popravljeno poglavje 4.8 v skladu s priporočili za povzetek glavnih značilnosti zdravila.
English: • The active substance is valaciclovir.
Slovenian: • Zdravilna učinkovina je valaciklovir.
English: The valaciclovir and aciclovir pharmacokinetic profiles are similar after single and repeat dosing.
Slovenian: Farmakokinetična profila valaciklovirja in aciklovirja sta po enkratnem in ponavljajočem se odmerjanju podobna.
English: Genital Herpes Suppression for Transmission Risk Reduction The MAH presented the Study HS2AB3009 to demonstrate the efficacy of valaciclovir suppressive therapy (500 mg once daily).
Slovenian: Supresija genitalnega herpesa za zmanjšanje tveganje prenosa Imetnik dovoljenja za promet z zdravilom je za dokaz učinkovitosti supresivnega zdravljenja z valaciklovirjem (500 mg enkrat dnevno) predložil študijo HS2AB3009.
English: 6.4 Special precautions for storage Store below 30°C.
Slovenian: POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi do 30 °C.
English: This conversion is probably mediated by an enzyme isolated from human liver referred to as valaciclovir hydrolase.
Slovenian: Pri pretvorbi verjetno sodeluje encim, ki so ga izolirali iz človeških jeter in se imenuje valaciklovir-hidrolaza.
English: Herpes zoster, herpes simplex and HIV infection do not significantly alter the pharmacokinetics of valaciclovir and aciclovir after oral administration of valaciclovir compared with healthy adults.
Slovenian: Herpes zoster, herpes simpleks in okužba s HIV farmakokinetike valaciklovirja in aciklovirja po peroralni uporabi valaciklovirja ne spremenijo bistveno v primerjavi z zdravimi odraslimi.
English: Aciclovir, the principle metabolite of valaciclovir, is excreted in breast milk.
Slovenian: Aciklovir, glavni presnovek valaciklovirja, se izloča v materinem mleku.
English: The first stage of phosphorylation requires the activity of a virus-specific enzyme.
Slovenian: Za prvo stopnjo fosforilacije je potrebna aktivnost encima, specifičnega za virus.
English: Resistance to aciclovir is normally due to a thymidine kinase deficient phenotype which results in a virus which is disadvantaged in the natural host.
Slovenian: Odpornost je po navadi posledica fenotipa s pomanjkanjem timidin-kinaze, kar pa je za virus v naravnem gostitelju velika pomanjkljivost.
English: Exposure to aciclovir and its metabolites CMMG and 8-OH-ACV in plasma and cerebrospinal fluid (CSF) was evaluated at steady-state after multiple-dose valaciclovir administration in 6 subjects with normal renal function (mean creatinine clearance 111 mL/min, range 91-144 mL/min) receiving 2000 mg every 6 hours and 3 subjects with severe renal impairment (mean CLcr 26 mL/min, range 17-31 mL/min) receiving 1500 mg every 12 hours.
Slovenian: Izpostavljenost aciklovirju in njegovima presnovkoma CMMG in 8-OH-ACV v plazmi in cerebrospinalni tekočini so ocenili v stanju dinamičnega ravnovesja po uporabi večkratnih odmerkov valaciklovirja pri 6 preiskovancih z normalnim delovanjem ledvic (povprečni očistek kreatinina 111 ml/min, razpon 91-144 ml/min), ki so dobivali 2000 mg na 6 ur, ter pri 3 preiskovancih s hudo okvaro ledvic (povprečni očistek kreatinina 26 ml/min, razpon 17-31 ml/min), ki so dobivali 1500 mg na 12 ur.
English: Valaciclovir is rapidly and almost completely converted in man to aciclovir and valine, probably by the enzyme referred to as valaciclovir hydrolase.
Slovenian: Pri človeku se valaciklovir hitro in skoraj popolnoma spremeni v aciklovir in valin, verjetno z encimom, imenovanim valaciklovir-hidrolaza.
English: Specific studies of valaciclovir have not been conducted in liver transplantation, and hence caution should be exercised when administering daily doses greater than 4000 mg to these patients.
Slovenian: Specifične študije valaciklovirja pri bolnikih s presajenimi jetri niso bile izvedene, zato je treba dnevne odmerke, večje od 4000 mg, pri teh bolnikih uporabljati previdno.
English: The MAH did a proposal for the harmonisation of valaciclovir SPCs taking into account the whole pharmaceutical presentations and all the dosages currently approved in at least one European MSs.
Slovenian: Imetnik dovoljenja za promet z zdravilom je predlagal uskladitev povzetkov glavnih značilnosti valaciklovirja z upoštevanjem celotne farmacevtske oblike in trenutno odobrenih odmerkov vsaj v eni državi članici EU.
English: Following oral administration of a 500 mg dose of valaciclovir, peak aciclovir concentrations (Cmax) in breast milk ranged from 0.5 to 2.3 times the corresponding maternal aciclovir serum concentrations.
Slovenian: Po peroralni uporabi 500 mg odmerka valaciklovirja je bila največja koncentracija (Cmax) aciklovirja v materinem mleku od 0,5- do 2,3-krat tolikšna kot ustrezna koncentracija aciklovirja v materinem serumu.
English: Valaciclovir 500 mg twice daily was superior to 1000 mg once daily for suppression of symptomatic recurrences Valaciclovir 1000 mg twice daily for treatment of recurrences was comparable to oral aciclovir 200 mg five times daily on herpes episode duration.
Slovenian: Odmerek valaciklovirja 500 mg dvakrat na dan je bil za supresijo simptomatskih ponovitev boljši od 1.000 mg enkrat na dan. Odmerek valaciklovirja 1.000 mg dvakrat na dan je bil za zdravljenje ponovitev primerljiv peroralnemu odmerku aciklovirja 200 mg petkrat na dan glede trajanja epizod herpesa.
English: The CHMP endorsed the MAH proposal to state, under this section, that valaciclovir should only be used in pregnancy if the potential benefits of treatment outweigh the potential risks.
Slovenian: CHMP je potrdil predlog imetnika dovoljenja za promet z zdravilom, da se v tem poglavju navede, da se lahko valaciklovir uporabi v nosečnosti le, če so potencialne koristi zdravljenja odtehtajo potencialna tveganja.
English: • prevent infection with CMV after organ transplants (in adults and adolescents over 12 years old)
Slovenian: • preprečevanje okužbe s CMV po presaditvi organa (pri odraslih in mladostnikih, starejših od 12
English: Section 4.3 Contraindications
Slovenian: Razdelek 4.3 Kontraindikacije
English: In addition, the MAH assessed reports of pregnancy and pregnancy outcomes available in the MAH's Worldwide Clinical Safety Database.
Slovenian: Poleg tega je imetnik dovoljenja za promet z zdravilom pregledal poročila o nosečnostih in njihovih izidih, ki so dostopni v imetnikovi svetovni zbirki podatkov o klinični varnosti.
English: Post Marketing Data Blood and lymphatic system disorders Uncommon:
Slovenian: Postmarketinški podatki Bolezni krvi in limfatičnega sistema Občasni:
English: Treatment of herpes labialis (cold sores) in immunocompetent adults and adolescents (alternative 1-day regimen)
Slovenian: Zdravljenje herpesa na ustnicah (ocvirkov) pri imunokompetentnih odraslih in mladostnikih (alternativna 1-dnevna shema)
English: 25 to <50
Slovenian: 25 do < 50
English: • You should take each dose about 6 hours apart.
Slovenian: • Odmerke morate jemati v približno šest-urnih presledkih.
English: The following side effects may happen with this medicine:
Slovenian: Uporaba tega zdravila lahko povzroči naslednje neželene učinke:
English: • The second dose should be taken 12 hours (no sooner than 6 hours) after the first dose
Slovenian: • Drugi odmerek je treba vzeti 12 ur (in ne prej kot 6 ur) po prvem odmerku.
English: 10 to <25
Slovenian: 10 do < 25
English: Valaciclovir has been proven to reduce the risk of transmission of genital herpes in immunocompetent adults when taken as suppressive therapy and combined with safer sex practices.
Slovenian: Dokazano je, da valaciklovir zmanjša tveganje prenosa genitalnega herpesa pri imunokompetentnih odraslih, če je uporabljen kot supresivno zdravljenje in v kombinaciji z ukrepi za varnejšo spolnost.
English: The CDC advocates that prompt antiviral therapy should be instituted in all immune-suppressed herpes zoster patients within 1 week of rash onset or any time before full crusting of lesions.
Slovenian: CDC zagovarja, da je treba pri vseh imunsko suprimiranih bolnikih s pasovcem hitro uvesti protivirusno zdravljenje v 1 tednu od pojava izpuščaja ali kadar koli pred popolnim zakrastenjem lezij.
English: HSV Suppression for Outbreak Reduction (recurrent episodes of genital herpes simples) The MAH in order to demonstrate efficacy in the suppression of genital herpes recurrences presented two Studies (123-026 and 123-037).
Slovenian: Supresija HSV za zmanjšanje pojava (ponavljajoče se epizode genitalnega herpesa simpleksa) Imetnik dovoljenja za promet z zdravilom je za dokaz učinkovitosti pri supresiji ponovitev genitalnega herpesa predložil dve študiji (123-026 in 123-037).
English: If you take too many tablets you may feel sick, vomit, or be confused, agitated or unusually sleepy.
Slovenian: Če vzamete preveč tablet, se vam lahko pojavijo slabost v želodcu, bruhanje, zmedenost, vznemirjenost ali nenavadna zaspanost.
English: United Kingdom The Wellcome Foundation Ltd Glaxo Wellcome House
Slovenian: Velika Britanija The Wellcome Foundation Ltd Glaxo Wellcome House
English: The CHMP concluded that the only ocular use that should be noted is the treatment of ophthalmic zoster.
Slovenian: CHMP je menil, da je edina očesna uporaba, ki se lahko navede, „zdravljenje očesnega zostra“.
English: Intravenous therapy generally is considered standard for zoster treatment in immunocompromised patients; however, limited data indicate a clinical benefit of valaciclovir in the treatment of VZV infection (herpes zoster) in certain immunocompromised patients, including those with solid organ cancer, HIV, autoimmune diseases, lymphoma, leukaemia and stem cell transplants.
Slovenian: Intravensko zdravljenje na splošno velja za standardno zdravljenje zostra pri imunsko oslabelih bolnikih; toda maloštevilni podatki kažejo klinično korist valaciklovirja za zdravljenje okužbe z VZV (herpesa zostra) pri nekaterih imunsko oslabelih bolnikih, med drugim pri bolnikih z rakom parenhimskih organov, HIV, avtoimunskimi boleznimi, limfomom, levkemijo in presaditvijo matičnih celic.
English: ≥ 1/10,000 to < 1/1000,
Slovenian: ≥ 1/10.000 do < 1/1000
English: Leucopenia, thrombocytopenia Leucopenia is mainly reported in immunocompromised patients.
Slovenian: levkopenija, trombocitopenija Levkopenija je bila opisana predvsem pri imunsko oslabelih bolnikih.
English: The MAH also stated that the pivotal studies of valaciclovir for treatment of HSV and VZV infections and for suppression of HSV recurrences had enrolment criteria that excluded most subjects with significant renal impairment.
Slovenian: Imetnik dovoljenja za promet z zdravilom je navedel tudi, da so ključne študije valaciklovirja za zdravljenje okužb s HSV in VZV ter supresijo ponovitev HSV vsebovale vključitveno merilo, ki je izločilo večino preiskovancev s pomembno okvaro delovanja ledvic.
English: In patients with normal renal function the plasma elimination half-life of aciclovir after both single and multiple dosing with valaciclovir is approximately 3 h.
Slovenian: Pri bolnikih z normalnim delovanjem ledvic je plazemski eliminacijski razpolovni čas aciklovirja po enkratnem in večkratnem odmerjanju valaciklovirja približno 3 ure.
English: The MAH stated that valaciclovir offered proven efficacy for prophylaxis of CMV infection and disease and influenced positively other outcomes such as graft rejection and opportunistic infections.
Slovenian: Imetnik dovoljenja za promet z zdravilom je navedel, da ima valaciklovir dokazano učinkovitost pri profilaksi okužb s CMV in bolezni CMV ter da pozitivno vpliva na druge izide, kot sta zavrnitev presadka in oportunistične okužbe.
English: Similarly, valaciclovir administration may increase plasma concentrations of the concurrently administered substance.
Slovenian: Podobno lahko tudi uporaba valaciklovirja poveča koncentracijo sočasno uporabljenih učinkovin v plazmi.
English: It works by killing or stopping the growth of viruses called herpes simplex (HSV), varicella zoster (VZV) and cytomegalovirus (CMV).
Slovenian: Deluje tako, da uniči ali ustavi rast virusov, imenovanih herpes simpleks (HSV), varicella zoster (VZV) in citomegalovirus (CMV).
English: Studies with a 1000 mg dose of valaciclovir in adult patients show that dose modification is not required in patients with mild or moderate cirrhosis (hepatic synthetic function maintained).
Slovenian: Študije z odmerkom 1.000 mg valaciklovirja pri odraslih bolnikih kažejo, da bolnikom z blago do zmerno cirozo (ohranjeno sintezno delovanje jeter) odmerka ni treba prilagoditi.
English: Results from Egan study indicated that high-dose valaciclovir significantly delayed the incidence of CMV antigenemia and had positive effects on time to CMV infections, symptoms and disease compared to low-dose oral aciclovir.
Slovenian: Rezultati Eganove študije so pokazali, da veliki odmerki valaciklovirja bistveno odložijo pojav antigenemije CMV in pozitivno učinkujejo na čas do okužbe, simptome in bolezen CMV v primerjavi z majhnimi peroralnimi odmerki aciklovirja.
English: Neurological disorders, sometimes severe, may be linked to encephalopathy and include confusion, agitation, convulsions, hallucinations, coma.
Slovenian: Z encefalopatijo so lahko povezane nevrološke motnje, včasih tudi hude, med njimi zmedenost, agitiranost, konvulzije, halucinacije, koma.
English: 1500 mg once daily a For patients on intermittent haemodialysis, the dose should be given after dialysis on dialysis days.
Slovenian: 1.500 mg enkrat na dan a Bolniki na intermitentni hemodializi morajo odmerek dobiti na dan dialize po dializiranju.
English: The CHMP agreed to insert under this section a reference to valaciclovir to reduce the risk of transmission of genital herpes in immunocompetent adults when taken as suppressive therapy and combined with safer sex practices.
Slovenian: CHMP se je strinjal, da se v to poglavje vključi sklic na uporabo valaciklovirja za zmanjšanje tveganja prenosa genitalnega herpesa pri imunsko kompetentnih odraslih osebah, če se jemlje kot supresivno zdravljenje in v kombinaciji s postopki varne spolnosti.
English: No human fertility studies were performed with valaciclovir, but no changes in sperm count, motility or morphology were reported in 20 patients after 6 months of daily treatment with 400 to 1000 mg aciclovir.
Slovenian: Z valaciklovirjem ni bilo izvedenih študij plodnosti pri človeku, toda pri 20 bolnikih , po 6-mesečnem vsakodnevnem zdravljenju s 400 do 1.000 mg aciklovirja niso ugotovili sprememb v številu semenčic, njihovi gibljivosti ali morfologiji.
English: In additional studies in rats, foetal abnormalities and maternal toxicity were observed at subcutaneous doses that produced plasma aciclovir levels of 100 micrograms/mL (>10-fold higher than 2000 mg single dose valaciclovir in humans with normal renal function).
Slovenian: V dodatnih študijah na podganah so opažali nepravilnosti plodov in toksične učinke pri samicah-materah med subkutano uporabo odmerkov, ki so povzročili koncentracijo aciklovirja v plazmi 100 mikrogramov/ml (to je > 10-krat več kot po enkratnem odmerku 2000 mg valaciklovirja pri človeku z normalnim delovanjem ledvic).
English: Microcrystalline cellulose Crospovidone Povidone
Slovenian: Jedro tablete Mikrokristalna celuloza Krospovidon Povidon
English: Valaciclovir, an antiviral, is the L-valine ester of aciclovir.
Slovenian: Protivirusno zdravilo valaciklovir je L-valinski ester aciklovirja.
English: • slow, slurred speech (dysarthria)
Slovenian: • počasno, nejasno govorjenje (dizartrija),
English: • You should take Valtrex until your doctor tells you to stop.
Slovenian: • Zdravilo Valtrex morate jemati, dokler vam zdravnik ne naroči, da z jemanjem prenehajte.
English: The MAH had no data indicating that patients with renal impairment have an altered PK/PD relationship compared with patients with normal renal function such that they would require higher aciclovir exposure for comparable treatment effect.
Slovenian: Imetnik dovoljenja za promet z zdravilom ni imel podatkov, ki bi kazali, da imajo bolniki z okvarjenim delovanjem ledvic spremenjeno odvisnost farmakokinetike/farmadinamike v primerjavi z bolniki z normalnim delovanjem ledvic in da bi potrebovali večjo izpostavljenost aciklovirju za primerljiv terapevtski učinek.
English: In study 123-012 the results indicate that prophylaxis with oral VACV in renal transplant patients reduced the incidence or delayed the onset of CMV disease in both the seropositive and the seronegative recipients.
Slovenian: V študiji 123-012 rezultati kažejo, da je profilaksa s peroralnim VACV pri prejemnikih ledvic zmanjšala pojavnost bolezni CMV ali zakasnila njen pojav pri seropozitivnih in seronegativnih prejemnikih.
English: As requested by the CHMP, the MAH reconsidered the use of valaciclovir for zoster treatment in immunocompromised patients and reviewed treatment guidelines.
Slovenian: Na prošnjo CHMP je imetnik dovoljenja za promet z zdravilom pretehtal uporabo valaciklovirja za zdravljenje pasovca pri imunsko kompromitiranih bolnikih ter pregledal priporočila za zdravljenje.
English: The combination of valaciclovir with nephrotoxic medicinal products should be made with caution, especially in subjects with impaired renal function, and warrants regular monitoring of renal function.
Slovenian: Pri uporabi valaciklovirja v kombinaciji z nefrotoksičnimi zdravili je potrebna previdnost, še zlasti pri osebah z okvarjenim delovanjem ledvic; v primeru takšne kombinirane uporabe je treba redno kontrolirati delovanje ledvic.
English: Varicella Zoster Virus Infection
Slovenian: Okužba z virusom varicella zoster
English: • feeling agitated
Slovenian: • občutek vznemirjenosti.
English: The CHMP requested the MAH to further discuss the proposed dose adjustment for renal impairment at one-day treatment of herpes labialis.
Slovenian: CHMP je prosil imetnika dovoljenja za promet z zdravilom, da dodatno pojasni predlagane prilagoditve odmerka pri okvari delovanja ledvic v primeru enodnevnega zdravljenja labialnega herpesa.
English: Suppression of HSV infections - immunocompetent adults and adolescents
Slovenian: Supresija okužb s HSV - imunokompetentni odrasli in mladostniki
English: Cytomegalovirus is a leading cause of virus-associated birth defects, including mental retardation and deafness and may cause severe and fatal diseases in immunocompromised individuals, particularly bone marrow transplant (BMT), solid organ transplantation recipients, and immunosuppressed patients as those with HIV.
Slovenian: Citomegalovirus je glavni vzrok z virusi povezanih okvar plodov, vključno z duševno zaostalostjo in gluhoto, in lahko povzroči hude in smrtno nevarne bolezni pri imunsko kompromitiranih osebah, zlasti pri prejemnikih kostnega mozga ali trdnega organa, imunsko suprimiranih bolnikih in bolnikih s HIV.
English: The safety profile of prophylactic IV treatment with ganciclovir and oral treatment with VACV were comparable and were both similar to that of the placebo group.
Slovenian: zdravljenja z ganciklovirjem in peroralnim zdravljenjem z VACV sta bila primerljiva in oba podobna varnostnemu profilu placeba.
English: The MAH completed two studies to determine the safety and efficacy of VACV compared to ACV or placebo for the prophylaxis of CMV infection and disease in solid organ transplant.
Slovenian: Imetnik dovoljenja za promet z zdravilom je opravil dve študiji za določitev varnosti in učinkovitosti VACV v primerjavi z ACV ali placebom za profilakso okužbe s CMV in bolezni CMV pri prejemnikih trdnega organa.
English: Renal pain may be associated with renal failure.
Slovenian: Ledvične bolečine so lahko povezane z odpovedjo ledvic.
English: The CHMP endorsed the MAH's proposal not to include the insertion of viral resistance in the Section 4.3.
Slovenian: CHMP je potrdil predlog imetnika dovoljenja za promet z zdravilom, da se v poglavje 4.3 ne vključi izjava o odpornosti virusov.
English: Elderly patients are likely to have reduced renal function and therefore the need for dose reduction must be considered in this group of patients.
Slovenian: Pri starejših bolnikih je možno zmanjšano delovanje ledvic, zato je pri teh bolnikih to potrebno upoštevati in po potrebi zmanjšati odmerek.
English: Use of higher doses of valaciclovir in hepatic impairment and liver transplantation There are no data available on the use of higher doses of valaciclovir (4000 mg or more per day) in patients with liver disease.
Slovenian: Uporaba velikih odmerkov valaciklovirja pri okvari jeter in presaditvi jeter O uporabi večjih odmerkov valaciklovirja (4.000 mg ali več na dan) pri bolnikih z boleznijo jeter.
English: Valtrex is an oral tablet containing valaciclovir (VACV), the esterified prodrug of the antiherpetic compound Aciclovir (ACV).
Slovenian: Zdravilo Valtrex je peroralna tableta, ki vsebuje valaciklovir (VACV), zaestreno predzdravilo antiherpetične spojine aciklovir (ACV).
English: The CHMP also asked the MAH to give reassurance that the benefit/risk of valaciclovir can be regarded as similar to that of valganciclovir, currently widely used in clinical practice.
Slovenian: CHMP je imetnika dovoljenja za promet z zdravilom vprašal tudi, če lahko zagotovi, da je razmerje med koristmi in tveganji za valaciklovir podobno valganciklovirju, ki se pogosto uporablja v klinični praksi.
English: In immunocompromised patients, antiviral treatment is suggested for patients presenting within one week of vesicle formation or at any time before full crusting of lesions.
Slovenian: Pri imunsko oslabelih bolnikih je protivirusno zdravljenje priporočljivo za bolnike, ki pridejo na pregled v enem tednu od nastanka mehurčkov ali kadarkoli pred popolnim nastankom krast na spremembah.
English: Psychiatric and nervous system disorders Common:
Slovenian: Psihiatrične motnje in bolezni živčevja Pogosti:
English: The dose in immunocompetent patients is 1000 mg three times daily for seven days (3000 mg total daily dose).
Slovenian: Pri imunokompetentnih bolnikih je odmerek 1.000 mg trikrat na dan sedem dni (celotni dnevni odmerek 3.000 mg).
English: Treatment of HSV infections of the skin and genital herpes
Slovenian: Zdravljenje okužb kože s HSV in genitalnega herpesa
English: Valaciclovir for ocular HSV infections should be given according to applicable treatment guidelines.
Slovenian: Okužba z virusom herpes simpleks Za očesne okužbe s HSV je treba valaciklovir dati v skladu z ustreznimi smernicami za zdravljenje.
English: The Wellcome Foundation Ltd. Greenford, Middlesex, United Kingdom
Slovenian: The Wellcome Foundation Ltd. Greenford, Middlesex, Velika Britanija
English: • for the treatment and suppression of HSV infections of the skin and mucous membranes including
Slovenian: • za zdravljenje in supresijo okužb HSV na koži in sluznicah, vključno z/s: