FrancophonIA/ELRC3.0 huggingface dataset:
English: EU/1/00/133/033 1 pen (SoloStar) EU/1/00/133/034 3 pens (SoloStar) EU/1/00/133/035 5 pens (SoloStar) EU/1/00/133/036 10 pens (SoloStar) EU/1/00/133/037 1 pen (DoubleStar) EU/1/00/133/038 3 pens (DoubleStar) EU/1/00/133/041 10 pens (DoubleStar)
Croatian: EU/1/00/133/033 1 brizgalica (SoloStar) EU/1/00/133/034 3 brizgalice (SoloStar) EU/1/00/133/035 5 brizgalica (SoloStar) EU/1/00/133/036 10 brizgalica (SoloStar) EU/1/00/133/037 1 brizgalica (DoubleStar) EU/1/00/133/038 3 brizgalice (DoubleStar) EU/1/00/133/041 10 brizgalica(DoubleStar)
English: Toujeo DoubleStar is made to deliver the number of insulin units that your doctor prescribed.
Croatian: Toujeo DoubleStar isporučit će broj jedinica koje je propisao Vaš liječnik.
English: The safety and efficacy of Toujeo administered with a fixed or flexible dosing time were also evaluated in 2 randomized, open-label clinical studies for 3 months.
Croatian: Sigurnost i djelotvornost lijeka Toujeo s fiksnim ili fleksibilnim vremenom primjene ocijenjene su i u dvama randomiziranim, otvorenim kliničkim ispitivanjima u trajanju od 3 mjeseca.
English: Signs in your brain include: headaches, feeling very hungry, feeling sick (nausea) or being sick (vomiting), feeling tired, sleepy, restless, sleeping problems, aggressive behaviour, difficulty concentrating, slow reactions, depression, feeling confused, difficulty speaking (sometimes total loss of speech), changes in your sight, trembling, being unable to move (paralysis), tingling in the hands or arms, feeling numb and tingling often around the mouth, feeling dizzy, loss of self-control, being unable to look after yourself, fits, passing out.
Croatian: Znakovi u mozgu uključuju: glavobolje, jaku glad, mučninu ili povraćanje, umor, pospanost, nemir, poteškoće sa spavanjem, agresivno ponašanje, poteškoće s koncentracijom, usporene reakcije, depresiju, smetenost, otežan govor (ponekad potpun gubitak sposobnosti govora), promjene vida, drhtanje, nemogućnost kretanja (paraliza), trnce u šakama i rukama (parestezije), utrnulost i trnce (često oko usta), omaglicu, gubitak samokontrole, nesposobnost vođenja brige o sebi, napadaje, gubitak svijesti.
English: A large amount of data on pregnant women (more than 1,000 pregnancy outcomes with a medicinal product containing insulin glargine 100 units/ml) indicate no specific adverse effects on pregnancy and no specific malformative nor feto/neonatal toxicity of insulin glargine.
Croatian: Velika količina podataka o trudnicama (više od 1000 ishoda trudnoća izloženih lijeku koji sadrži inzulin glargin jačine 100 jedinica/ml) ne ukazuje ni na kakve specifične štetne učinke na trudnoću niti na specifične malformacije i fetalnu/neonatalnu toksičnost inzulina glargina.
English: • Low blood sugar means that there is not enough sugar in your blood.
Croatian: • Niska razina šećera u krvi znači da nema dovoljno šećera u krvi.
English: o To reduce potential underdose, Toujeo DoubleStar is recommended for patients requiring at least 20 units per day.
Croatian: o Kako bi se izbjegla moguća nedostatna doza, Toujeo DoubleStar se preporuča za bolesnike kojima je potrebno najmanje 20 jedinica dnevno.
English: Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors for development of cardiac heart failure.
Croatian: Prijavljeni su slučajevi zatajivanja srca kod primjene pioglitazona u kombinaciji s inzulinom, osobito u bolesnika koji su imali čimbenike rizika za razvoj zatajivanja srca.
English: • Test your blood sugar level and your urine for ketones as soon as you notice any of the above signs.
Croatian: • Provjerite razinu šećera u krvi i prisutnost ketona u mokraći čim primijetite neki od gore navedenih znakova.
English: Toujeo contains 3 times more insulin in 1 ml than standard insulin, which contains 100 unit/ml.
Croatian: Toujeo sadrži trostruko više inzulina u 1 ml nego standardni inzulin, koji sadrži 100 jedinica/ml.
English: • To avoid an insulin underdose, perform safety tests before the first use of a new pen and also before every use of the pen (see Step 3 of the Instrucions for use).
Croatian: • kako bi se izbjegla primjena nedostatne doze napravite testove sigurnosti prije prve primjene nove brizgalice i također prije svakog korištenja brizgalice (vidjeti 3. Korak uputa za uporabu).
English: This helps stop blocked needles, contamination and infection.
Croatian: Tako ćete pomoći spriječiti začepljenje igle, onečišćenje i infekciju.
English: • Do not dial your dose by counting the clicks.
Croatian: • Nemojte birati dozu brojanjem klikova.
English: On the basis of the scientific conclusions for insulin glargine the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing insulin glargine is unchanged subject to the proposed changes to the product information
Croatian: Na temelju znanstvenih zaključaka za inzulin glargin, CHMP smatra da je omjer koristi i rizika lijeka(ova) koji sadrži(e) inzulin glargin nepromijenjen, uz predložene izmjene informacija o lijeku.
English: Using a new sterile needle for each injection also minimizes the risk of contamination and infection.
Croatian: Uporaba nove sterilne igle ujedno minimizira i rizik od onečišćenja i infekcije.
English: • Information so that others know you have diabetes.
Croatian: • informaciju o tome da bolujete od šećerne bolesti.
English: • You can clean the outside of your pen by wiping it with a damp cloth.
Croatian: • Možete očistiti vanjski dio brizgalice tako da ga obrišete vlažnom krpom.
English: Based on the results from clinical studies, the safety profile of Toujeo in elderly patients and in patients with renal impairment was similar to that of the overall population (see section 5.1).
Croatian: S obzirom na rezultate kliničkih ispitivanja, sigurnosni profil lijeka Toujeo u starijih bolesnika i bolesnika s oštećenjem funkcije bubrega bio je sličan onome u cjelokupnoj populaciji (vidjeti dio 5.1).
English: Administration with a flexible dosing time had no effect on glycaemic control and the incidence of hypoglycaemia.
Croatian: Fleksibilno vrijeme primjene nije utjecalo na regulaciju glikemije niti na incidenciju hipoglikemije.
English: Each line in the dose window is an even number:
Croatian: Jedna linija u prozorčiću za prikaz doze je parni broj:
English: Efficacy and safety data for paediatric patients with type 2 diabetes mellitus have been extrapolated from data for adolescent and adult patients with type 1 diabetes mellitus and adult patients with type 2 diabetes mellitus.
Croatian: Podaci o djelotvornosti i sigurnosti za pedijatrijske bolesnike sa šećernom bolešću tipa 2 ekstrapolirani su iz podataka za adolescentne i odrasle bolesnike sa šećernom bolešću tipa 1 i odrasle bolesnike sa šećernom bolešću tipa
English: b Confirmed hypoglycaemia: Any severe hypoglycaemia and/or hypoglycaemia confirmed by plasma glucose value ≤3.9 mmol/l.
Croatian: Potvrđena hipoglikemija: svaka epizoda teške hipoglikemije i/ili hipoglikemija potvrđena vrijednošću glukoze u plazmi od ≤3,9 mmol/l.
English: Prolonged or severe hypoglycaemic episodes may be life-threatening.
Croatian: Dugotrajne ili teške epizode hipoglikemije mogu biti opasne po život.
English: When needed, Toujeo can be injected up to 3 hours before or after the time you usually inject it.
Croatian: Ako je potrebno, Toujeo se može injicirati do 3 sata prije ili nakon vremena kada ga obično primjenjujete.
English: The solution should be clear, colourless and water-like.
Croatian: Otopina mora biti bistra, bezbojna i vodenasta.
English: What Toujeo is and what it is used for What you need to know before you use Toujeo How to use Toujeo
Croatian: Što je Toujeo i za što se koristi Što morate znati prije nego počnete primjenjivati Toujeo Kako primjenjivati Toujeo
English: You should know these factors so that you can take the right action if your blood sugar level changes and help step it becoming too high or too low.
Croatian: Morate ih poznavati kako biste znali što učiniti ako se promijeni razina šećera u krvi i kako spriječiti da ona postane previsoka ili preniska.
English: • You may see air bubbles in the insulin.
Croatian: Ako vidite mjehuriće zraka • Možda ćete vidjeti mjehuriće zraka u inzulinu.
English: A Choose a place to inject as shown in the picture labelled “Places to inject” B Push the needle into your skin as shown by your doctor, pharmacist or nurse.
Croatian: Odaberite mjesto za injiciranje kako je prikazano na slici „Mjesta za injiciranje“ B Ubodite iglu u kožu na način koji su Vam pokazali Vaš liječnik, ljekarnik ili medicinska sestra.
English: After subcutaneous injection of Toujeo, the intra-subject variability, defined as the coefficient of variation for the insulin exposure during 24 hours was low at steady state (17.4%).
Croatian: Nakon supkutane primjene lijeka Toujeo, intraindividualna varijabilnost, koja se definira kao koeficijent varijacije za izloženost inzulinu tijekom 24 sata, bila je niska u stanju dinamičke ravnoteže
English: The dose-response analysis showed that following the initial titration phase, the body weight adjusted doses in pediatric patients are higher than in adult patients at steady state.
Croatian: Analiza odnosa doze i učinka pokazala je da su, nakon početnog perioda titracije, doze prilagođene prema tjelesnoj težini više kod pedijatrijskih bolesnika nego kod odraslih bolesnika u stanju dinamičke ravnoteže.
English: The dose delivered is the one shown in the dose window.
Croatian: Doza koja se isporučuje je prikazana na prozorčiću za prikaz doze.
English: These cases did not contain confounders and have a compatible time to onset.
Croatian: U tim slučajevima nisu postojali nikakvi ometajući faktori, a vrijeme do nastupa bilo je kompatibilno.
English: If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and oedema.
Croatian: U slučaju primjene ove kombinacije, potrebno je nadzirati bolesnike zbog moguće pojave znakova i simptoma zatajivanja srca, porasta tjelesne težine i edema.
English: If you don't, your full dose will not be delivered.
Croatian: vaša puna doza neće biti isporučena.
English: • Key messages to convey in patients counselling: - Patients need to be instructed that insulin glargine 100 units/ml products and Toujeo are not interchangeable and dose adjustments need to be made;
Croatian: • Ključne poruke za savjetovanje bolesnika: - Bolesnike treba uputiti da pripravci inzulina glargina od 100 jedinica/ml i Toujeo nisu međusobno zamjenjivi i da je potrebno prilagoditi dozu; -
English: IGF-1 receptor binding: The affinity of insulin glargine for the human IGF-1 receptor is approximately 5 to 8-fold greater than that of human insulin (but approximately 70 to 80-fold lower than the one of IGF-1), whereas M1 and M2 bind the IGF-1 receptor with slightly lower affinity compared to human insulin.
Croatian: Vezivanje za IGF-1 receptor: Afinitet inzulina glargina za ljudski IGF-1 receptor približno je 5-8 puta veći nego afinitet ljudskog inzulina (ali približno 70-80 puta manji nego afinitet IGF-1 proteina), dok se metaboliti M1 i M2 vezuju za IGF-1 receptor s nešto manjim afinitetom nego ljudski inzulin.
English: *GIR: Glucose infusion rate: determined as amount of glucose infused to maintain constant plasma glucose levels (hourly mean values).
Croatian: *GIR (engl. glucose infusion rate): brzina infuzije glukoze - određuje se kao količina infundirane glukoze potrebna za održavanje stalne razine glukoze u plazmi (srednja vrijednost/sat).
English: Beta-blockers like other “Sympatholytic medicines” (such as clonidine, guanethidine, reserpine - for high blood pressure) may make it harder to recognise warning signs of your blood sugar being too low (hypoglycaemia).
Croatian: Beta-blokatori, poput drugih 'simpatolitičkih lijekova' (kao što su klonidin, gvanetidin i rezerpinkoriste se za liječenje visokog krvnog tlaka), mogu otežati prepoznavanje simptoma koji upozoravaju na prenisku razinu šećera u krvi (hipoglikemiju).
English: STEP 5: Inject your dose
Croatian: 5. KORAK: Injicirajte dozu
English: The MAH shall ensure that in each Member State where Toujeo 300 units/ml is marketed, all healthcare professionals (HCPs) who are expected to prescribe or dispense Toujeo 300 units/ml, as well as all patients or their carers who are expected to use Toujeo 300 units/ml, are provided with educational material to address the risk(s) of Medication error (switching between 100 units/ml and 300 units/ml without dose adjustment).
Croatian: Nositelj odobrenja će u svakoj državi članici u kojoj se lijek Toujeo 300 jedinica/ml nalazi u prometu osigurati da su svi zdravstveni djelatnici za koje se očekuje da će propisivati ili izdavati Toujeo 300 jedinica/ml, kao i svi bolesnici ili njihovi skrbnici koji će koristiti Toujeo 300 jedinica/ml, opskrbljeni edukacijskim materijalom kojim se upoznaju s rizikom (rizicima) od medikacijske pogreške (prijelaz sa 100 jedinica/ml na 300 jedinica/ml bez prilagodbe doze).
English: If any of the above apply to you (or you are not sure), talk to your doctor, pharmacist or nurse before using Toujeo.
Croatian: Ako se bilo što od gore navedenog odnosi na Vas (ili ako niste sigurni), obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego primijenite Toujeo.
English: • Read the instructions for use that come with this package leaflet.
Croatian: • Pročitajte upute za uporabu koja dolaze s ovom uputom o lijeku.
English: Mixing or diluting Toujeo changes its time/action profile and mixing causes precipitation.
Croatian: Miješanje ili razrjeđivanje lijeka Toujeo mijenja njegov profil djelovanja kroz vrijeme, a miješanje uzrokuje i precipitaciju.
English: *RR: estimated risk ratio; [95% Confidence Interval]
Croatian: 6-mjesečno razdoblje liječenja *RR: procijenjen omjer rizika; [interval pouzdanosti od 95%]
English: Improvement in HbA1C was not affected by, gender, ethnicity, age, diabetes duration (<10 years and ≥10 years), HbA1c value at baseline (<8% or ≥8%) or baseline body mass index (BMI).
Croatian: Na poboljšanje razine HbA1c nisu utjecali spol, etnicitet, dob, trajanje šećerne bolesti (<10 godina i ≥10 godina), razina HbA1c na početku ispitivanja (<8% ili ≥8%) ni indeks tjelesne mase (ITM) na početku ispitivanja.
English: After injection into the subcutaneous tissue, the acidic solution is neutralised leading to formation of a precipitate from which small amounts of insulin glargine are continuously released.
Croatian: Nakon injekcije u potkožno tkivo kisela se otopina neutralizira i stvara se precipitat iz kojega se neprestano otpuštaju male količine inzulina glargina.
English: The use of Toujeo may be considered during pregnancy, if clinically needed.
Croatian: Može se razmotriti primjena lijeka Toujeo tijekom trudnoće, ako je to klinički opravdano.
English: Patients must also be instructed to not re-use needles.
Croatian: Bolesnike se također mora savjetovati da nikada ne upotrebljavaju ponovno istu iglu.
English: • Do not drop your pen or knock it against hard surfaces.
Croatian: • Pazite da brizgalica ne padne na pod ili udari u tvrdu površinu.
English: There were no differences between insulin glargine and standard care for the two co-primary outcomes; for any component endpoint comprising these outcomes; for all-cause mortality; or for the composite microvascular outcome.
Croatian: Nisu primijećene razlike između inzulina glargina i standardnog liječenja za dva primarna ishoda, za bilo koju mjeru koja je bila sastavnica navedenih ishoda, smrtnost zbog bilo kojeg uzroka niti kompozitni mikrovaskularni ishod.
English: After first use or if carried as a spare
Croatian: Nakon prve uporabe ili rezervne brizgalice
English: • Your insulin pen does not work properly.
Croatian: • inzulinska brizgalica ne radi ispravno
English: In a clinical pharmacology study, intravenous insulin glargine and human insulin have been shown to be equipotent when given at the same doses.
Croatian: U jednom se kliničkom farmakološkom ispitivanju pokazalo da su intravenski primijenjen inzulin glargin i ljudski inzulin ekvipotentni kada se daju u istim dozama.
English: Only use needles that are compatible for use with Toujeo DoubleStar (e.g. needles from BD, Ypsomed, Artsana or Owen Mumford) that are 8 mm long or shorter.
Croatian: Koristite samo igle koje su kompatibilne za uporabu s lijekom Toujeo DoubleStar (igle proizvođača BD, Ypsomed, Artsana ili Owen Mumford) koje su duge 8 mm ili kraće.
English: In addition, under the influence of sympatholytic medicinal products such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation may be reduced or absent.
Croatian: Osim toga, pod utjecajem simpatolitika poput beta-blokatora, klonidina, gvanetidina i rezerpina, mogu oslabjeti ili potpuno izostati znakovi adrenergičke proturegulacije.
English: • The other ingredients are: zinc chloride, metacresol, glycerol, water for injections, and sodium hydroxide (see section 2 “Important information about some of the ingredients of Toujeo”) and hydrochloric acid (for pH adjustment).
Croatian: • Drugi sastojci su: cinkov klorid, metakrezol, glicerol, voda za injekcije, natrijev hidroksid (pogledajte odlomak 'Važne informacije o nekim sastojcima lijeka Toujeo' u dijelu 2.) i kloridna kiselina (za prilagodbu pH).
English: The strength is highlighted in honey gold on the label of your Toujeo DoubleStar pre-filled pen.
Croatian: Jačina je istaknuta zlatnom bojom meda na naljepnici Vaše Toujeo DoubleStar napunjene brizgalice.
English: • Eye reactions: A big change in your blood sugar control (getting better or worse) can disturb your vision.
Croatian: Velike promjene u regulaciji razine šećera u krvi (poboljšanje ili pogoršanje) mogu utjecati na vid.
English: To avoid dosing errors and potential overdose, the patients must be instructed to never use a syringe to remove Toujeo (insulin glargine 300 units/ml) from the Toujeo SoloStar pre-filled pen or Toujeo DoubleStar pre-filled pen (see section 4.9 and 6.6).
Croatian: Kako bi se izbjegle pogreške u doziranju i moguće predoziranje, bolesnike se mora savjetovati da nikad ne koriste štrcaljku kako bi izvukli Toujeo (inzulin glargin 300 jedinica/ml) iz napunjene brizgalice Toujeo SoloStar ili napunjene brizgalice Toujeo DoubleStar (vidjeti dijelove 4.9 i 6.6).
English: Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.
Croatian: Inzulin i njegovi analozi snižavaju razinu glukoze u krvi potičući perifernu pohranu glukoze, posebice u skeletnu muskulaturu i masno tkivo, te inhibirajući stvaranje glukoze u jetri.
English: Particular caution should be exercised, and intensified blood glucose monitoring is advisable in patients in whom hypoglycaemic episodes might be of particular clinical relevance, such as in patients with significant stenosis of the coronary arteries or of the blood vessels supplying the brain (risk of cardiac or cerebral complications of hypoglycaemia) as well as in patients with proliferative retinopathy, particularly if not treated with photocoagulation (risk of transient amaurosis following hypoglycaemia).
Croatian: Poseban oprez i pojačana kontrola glukoze u krvi preporučuju se u bolesnika u kojih epizode hipoglikemije mogu biti klinički posebno značajne, poput bolesnika sa značajnom stenozom koronarnih arterija ili krvnih žila koje opskrbljuju mozak (rizik od srčanih ili cerebralnih komplikacija hipoglikemije) te bolesnika s proliferativnom retinopatijom, naročito ako nije liječena fotokoagulacijom (rizik od prolazne amauroze uslijed hipoglikemije).
English: This could cause high blood sugar.
Croatian: Ovo može uzrokovati povišenu razinu šećera u krvi.
English: • You have recently changed from an animal insulin to a human insulin, like Toujeo.
Croatian: • ako ste nedavno prešli s inzulina životinjskog podrijetla na ljudski inzulin, kao što je Toujeo
English: If you notice signs of your blood sugar being too low (hypoglycaemia), take action to increase your blood sugar level straight away (see the box at the end of this leaflet).
Croatian: Ako primijetite znakove preniske razine šećera u krvi (hipoglikemija), odmah poduzmite mjere za povećanje razine šećera u krvi (pogledajte uokviren tekst na kraju ove Upute).
English: However, intensification of insulin therapy with abrupt improvement in glycaemic control may be associated with temporary worsening of diabetic retinopathy.
Croatian: Međutim, intenziviranje inzulinskog liječenja praćeno naglim poboljšanjem regulacije glikemije može biti povezano s privremenim pogoršanjem dijabetičke retinopatije.
English: • You have just started insulin treatment or changed to another insulin - if low blood sugar occurs, it may be more likely to happen in the morning.
Croatian: • ako ste tek započeli liječenje inzulinom ili ako ste prešli na neki drugi inzulin - ako se javi hipoglikemija, veća je vjerojatnost da će nastupiti ujutro
English: It must only be used if the solution is clear, colourless, with no solid particles visible, and if it is of water-like consistency.
Croatian: Uložak se smije upotrijebiti samo ako je otopina bistra, bezbojna, vodenasta i ako nema vidljivih krutih čestica.
English: If you have missed a dose of Toujeo or if you have not injected enough insulin, your blood sugar level may become too high (hyperglycaemia):
Croatian: Ako ste propustili dozu lijeka Toujeo ili niste injicirali dovoljno inzulina, razina šećera u krvi može postati previsoka (hiperglikemija):
English: Get help from a person with good eye sight who is trained in using the pen.
Croatian: Zatražite pomoć osobe koja dobro vidi i obučena je za uporabu brizgalice.
English: • When to check your blood sugar level and if you need to carry out urine tests.
Croatian: • kada trebate provjeravati razinu šećera u krvi i trebate li napraviti pretrage mokraće
English: After subcutaneous injection of insulin glargine, insulin glargine is rapidly metabolized at the carboxyl terminus of the Beta chain with formation of two active metabolites M1 (21A-Gly-insulin) and M2 (21A-Gly-des-30B-Thr-insulin).
Croatian: Inzulin glargin se nakon supkutane primjene brzo metabolizira na karboksilnim krajevima beta lanca, pri čemu nastaju dva aktivna metabolita: M1 (21A-Gly-inzulin) i M2 (21A-Gly-des-30B-Thr-inzulin).
English: The total therapeutic insulin concentration (insulin glargine and its metabolites) found in type 1 diabetic patients was markedly lower than what would be required for a half maximal occupation of the IGF-1 receptor and the subsequent activation of the mitogenic-proliferative pathway initiated by the IGF-1 receptor.
Croatian: Ukupna terapijska koncentracija inzulina (inzulina glargina i metabolita) nađena u bolesnika sa šećernom bolešću tipa 1 bila je značajno niža od koncentracije potrebne za dostizanje polovice maksimalnog zasićenja IGF-1 receptora i posljedične aktivacije mitogeno-proliferativnog puta koji se inicira putem IGF-1 receptora.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON Multipack (contains Blue Box)
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU VANJSKA KUTIJA Višestruko pakiranje (sadrži plavi okvir)
English: Used needles should be thrown away in a puncture resistant container or disposed of in accordance with local requirements.
Croatian: Upotrijebljene igle moraju se odložiti u neprobojan spremnik ili zbrinuti sukladno lokalnim propisima.
English: • Set the dose by turning the dose selector to a line in the dose window.
Croatian: • Postavite dozu okrećući izbornik doze na liniju u prozorčiću za prikaz doze.
English: • You inject too much insulin.
Croatian: • injicirate previše inzulina
English: If you are 65 years or older, talk to your doctor as you may need a lower dose.
Croatian: Primjena u starijih bolesnika (u dobi od 65 i više godina) Ako imate 65 ili više godina, razgovarajte sa svojim liječnikom jer ćete možda trebati nižu dozu.
English: Rarely, insulin may cause oedema particularly if previously poor metabolic control is improved by intensified insulin therapy.
Croatian: U rijetkim slučajevima inzulin može uzrokovati edeme, pogotovo ako je ranija slaba regulacija metabolizma poboljšana intenziviranom inzulinskom terapijom.