FrancophonIA/ELRC3.0 huggingface dataset:
English: A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from melatonin therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Croatian: Mora se donijeti odluka o prestanku dojenja ili trajnom/privremenom prekidu terapije melatoninom, uzimajući u obzir korist dojenja za dijete i korist terapije za ženu.
English: Thioridazine and imipramine
Croatian: Tioridazin i imipramin
English: 4.7 Effects on ability to drive and use machines Melatonin has a moderate influence on the ability to drive and use machines.
Croatian: 4.7 Utjecaj na sposobnost upravljanja vozilima i rada sa strojevima Melatonin umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
English: Therefore the medicinal product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety (see section 4.7).
Croatian: Stoga se lijek mora upotrebljavati oprezno jer će učinci omamljenosti vjerojatno biti povezani sa sigurnosnim rizicima (vidjeti dio 4.7).
English: Taking more than the recommended daily dose may make you/your child feel drowsy.
Croatian: Ako uzmete više od preporučene dnevne doze, Vi/Vaše dijete možete osjećati omamljenost.
English: Crushing and chewing damages the special properties of the tablet and means that they will not work properly.
Croatian: Drobljenje i žvakanje oštećuju posebna svojstva tablete što znači da one neće djelovati na odgovarajući način.
English: The kinetics of melatonin are linear over the range of 2-8 mg.
Croatian: Kinetika melatonina je linearna u rasponu od 2 do 8 mg.
English: In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between melatonin and zolpidem one hour following co-dosing.
Croatian: U kliničkom su ispitivanju postojali jasni dokazi prolazne farmakodinamičke interakcije između melatonina i zolpidema jedan sat nakon istodobnog doziranja.
English: The activity of melatonin at the melatonin receptors (MT1, MT2 and MT3) is believed to contribute to its sleep-promoting properties, as these receptors (mainly MT1 and MT2) are involved in the regulation of circadian rhythms and sleep regulation.
Croatian: Vjeruje se da djelovanje melatonina na receptore melatonina (MT1, MT2 i MT3) pridonosi njegovim svojstvima da potiče spavanje jer su ti receptori (uglavnom MT1 i MT2) uključeni u regulaciju cirkadijanog ritma i sna.
English: The recommended starting dose is 2 mg (two 1-mg tablets) once daily.
Croatian: Preporučena početna doza iznosi 2 mg (dvije tablete od 1 mg) jednom dnevno.
English: The patient should be monitored at regular intervals (at least every 6 months) to check that Slenyto is still the most appropriate treatment.
Croatian: Bolesnika je potrebno pratiti u redovitim vremenskim razmacima (najmanje svakih 6 mjeseci) kako bi se utvrdilo je li lijek Slenyto i dalje najprikladnije liječenje.
English: In the absence of specific studies in children, the drug interactions with melatonin are those known in adults.
Croatian: U nedostatku specifičnih ispitivanja u djece, interakcije lijekova s melatoninom su one opažene u odraslih.
English: DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 20 September 2018
Croatian: Datum prvog odobrenja: 20. rujna 2018
English: Patients had a significantly decreased total excretion of 6-sulfatoxymelatonin compared with controls.
Croatian: Bolesnici su imali značajno smanjeno ukupno izlučivanje 6-sulfatoksimelatonina u usporedbi s kontrolnom skupinom.
English: If a lower treatment effect is seen after titration to a higher dose, the prescriber should first consider a down-titration to a lower dose before deciding on a complete discontinuation of treatment.
Croatian: Ako se primijeti manji učinak liječenja nakon titracije na veću dozu, liječnik koji propisuje lijek prvo treba razmotriti titraciju na manju dozu prije nego što donese odluku o potpunom prekidu liječenja.
English: Tell your doctor or pharmacist if you or your child is taking, has recently taken or might take any other medicines.
Croatian: Obavijestite svog liječnika ili ljekarnika ako Vi ili Vaše dijete uzimate, nedavno ste uzeli ili biste mogli uzimati bilo koje druge lijekove.
English: After 2 weeks withdrawal on placebo, a descriptive reduction in most scores was seen but levels were still significantly better than baseline levels with no signs of rebound effects.
Croatian: Nakon 2 tjedna od prestanka uzimanja lijeka Slenyto na placebu, opaženo je opisno smanjenje u većini rezultata, no razine su i dalje bile značajno bolje od početnih razina, bez znakova povratnog učinka.
English: • Swelling and inflammation of the sinuses associated with pain and blocked nose (sinusitis)
Croatian: • oticanje i upala sinusa povezana s bolom i začepljenim nosom (sinusitis)
English: In particular, taking Slenyto with the following medicines can increase the risk of side effects, or it can affect the way that Slenyto or the other medicine works:
Croatian: Uzimanje lijeka Slenyto posebice s lijekovima navedenim u nastavku može povećati rizik od nuspojava ili može utjecati na način na koji Slenyto ili drugi lijekovi djeluju:
English: 74 patients completed 104 weeks of treatment, 39 completed 2 years and 35 completed 21 months of Slenyto treatment.
Croatian: Liječenje lijekom Slenyto u trajanju od 104 tjedna dovršilo je 74 bolesnika, 39 ih je dovršilo dvije godine, a 35 je dovršilo 21 mjesec liječenja.
English: If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Croatian: Ako ste trudni ili dojite, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svojem liječniku za savjet prije uzimanja ovog lijeka.
English: What Slenyto is and what it is used for What you need to know before you or your child takes Slenyto How to take Slenyto
Croatian: Što je Slenyto i za što se primjenjuje Što trebate znati prije nego što Vi ili Vaše dijete uzmete Slenyto Kako uzimati Slenyto
English: Do not break, crush or chew the tablet.
Croatian: Ne lomiti, drobiti niti žvakati tablete.
English: • non-steroidal anti-inflammatory medicines such as aspirin and ibuprofen (used for treating pain and inflammation).
Croatian: • nesteroidni protuupalni lijekovi kao što su aspirin i ibuprofen (koriste se za liječenje boli i upale).
English: Beta-blockers may supress the night-time release of endogenous melatonin and thus should be administered in the morning.
Croatian: Beta-blokatori mogu suzbiti oslobađanje endogenog melatonina tijekom noći te bi ih stoga trebalo primijeniti ujutro.
English: Pharmacotherapeutic group: Psycholeptics, melatonin receptor agonists, ATC code: N05CH01 Mechanism of action
Croatian: Farmakoterapijska skupina: psiholeptici, agonisti melatoninskih receptora, ATK oznaka: N05CH01 Mehanizam djelovanja
English: Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible.
Croatian: Stoga su moguće interakcije između melatonina i drugih djelatnih tvari, kao posljedica njihova učinka na CYP1A enzime.
English: Externalizing behaviours
Croatian: Eksternalizirana ponašanja
English: You or your child should be monitored by your doctor at regular intervals (recommended every 6 months) to check that Slenyto is still the right treatment for you/them.
Croatian: Vaš liječnik treba pratiti Vas ili Vaše dijete u redovitim razmacima (preporučuje se svakih šest mjeseci) kako bi provjerio je li Slenyto i dalje dobro liječenje za Vas/dijete.
English: The principal metabolite is 6-sulfatoxy-melatonin (6-S-MT), which is inactive.
Croatian: Glavni metabolit je 6-sulfatoksimelatonin (6-S-MT), koji nije aktivan.
English: • Fits (epilepsy)
Croatian: • napadaji (epilepsija)
English: Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Croatian: Detaljne informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove http://www.ema.europa.eu
English: Melatonin may cause drowsiness, therefore melatonin should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Croatian: Melatonin može prouzročiti omamljenost te se stoga mora upotrebljavati oprezno jer će učinci omamljenosti vjerojatno biti povezani sa sigurnosnim rizicima.
English: Two liver-mediated metabolic pathways account for around 90% of melatonin metabolism.
Croatian: Dva metabolička puta posredovana jetrom predstavljaju oko 90% metabolizma melatonina.
English: How much
Croatian: Koliko
English: For social functioning (CGAS), the differences between Slenyto and placebo were small and not statistically significant (Table 1).
Croatian: Children's Global Assessment Scale, CGAS), razlike između lijeka Slenyto i placeba bile su malene i nisu bile statistički značajne (Tablica 1).
English: The tablet should not be broken, crushed or chewed because it will lose the prolonged release properties.
Croatian: Tablete se ne smiju lomiti, drobiti ni žvakati jer će time izgubiti svojstva produljenog oslobađanja.
English: The most frequently reported adverse reactions with Slenyto in clinical studies were somnolence, fatigue, mood swings, headache, irritability, aggression and hangover occurring in 1:100-1:10 children.
Croatian: Najčešće prijavljene nuspojave povezane s lijekom Slenyto u kliničkim ispitivanjima bile su somnolencija, umor, promjene raspoloženja, glavobolja, razdražljivost, agresivnost i mamurnost koje su se pojavile u 1:100 do 1:10 djece.
English: The tablets should be swallowed whole and NOT broken, crushed or chewed.
Croatian: Tablete je potrebno progutati cijele, te se NE smiju lomiti, drobiti ni žvakati.
English: If overdose occurs, drowsiness is to be expected.
Croatian: Ako dođe do predoziranja, očekuje se da će doći do omamljenosti.
English: If the tablets are mixed with any other type of food, the tablets may not work properly.
Croatian: Ako se tablete miješaju s bilo kojom drugom vrstom hrane, one možda neće djelovati na odgovarajući način.
English: Under fasted conditions Cmax was lower (1.73 ng/ml) and tmax was earlier (within 2 hours) with a minor effect on AUC-∞ that was slightly reduced (-14%) as compared to fed state.
Croatian: U uvjetima natašte, Cmax je bio niži (1,73 ng/ml) a tmax je bio ranije (u roku od dva sata) s manjim učinkom na AUC-∞ koji je bio neznatno snižen (-14 %) u usporedbi sa stanjem nakon jela.
English: • Abnormal behaviour
Croatian: • abnormalno ponašanje
English: - feels drowsy (see section below on “Driving and using machines”).
Croatian: - osjećate omamljeno (vidjeti dio „Upravljanje vozilima i strojevima” u nastavku).
English: A 3-4-fold increase in Cmax is apparent for women compared to men.
Croatian: Cmax je 3-4 puta veći u žena nego u muškaraca.
English: Altogether, melatonin metabolism declines with age, with pre-pubertal and pubertal metabolism faster than at older age.
Croatian: Metabolizam melatonina općenito opada s godinama; metabolizam osoba pretpubertetske i pubertetske dobi brži je nego u starijoj dobi.
English: The second, less significant, pathway is 5-demethylation to yield a physiological melatonin precursor, N-acetylserotonin.
Croatian: Drugi, manje značajan put je 5-demetilacija kojom nastaje fiziološki prekursor melatonina, N-acetilserotonin.
English: If possible, administration of NSAIDs should be avoided in the evening.
Croatian: Ako je moguće, primjenu nesteroidnih protuupalnih lijekova potrebno je izbjegavati uvečer.
English: Prepubertal children and young adults metabolize melatonin faster than adults.
Croatian: Djeca pretpubertetske dobi i mlade odrasle osobe melatonin metaboliziraju brže od odraslih.
English: p-value*
Croatian: vrijednost*
English: In studies performed in both adult and juvenile animals, melatonin had no effect on male or female fertility (see section 5.3).
Croatian: U ispitivanjima provedenima na odraslim jedinkama životinja i mladunčadi životinja melatonin nije imao utjecaja na plodnost mužjaka ni ženki (vidjeti dio 5.3).
English: Data in animals indicate maternal transfer of melatonin to the foetus via the placenta or in the milk.
Croatian: Podatci iz ispitivanja na životinjama ukazuju na prijenos melatonina s majke na fetus putem posteljice ili mlijeka.
English: If you or your child takes more Slenyto than you/they should If you/your child has accidentally taken too much medicine, contact the doctor or pharmacist as soon as possible.
Croatian: Ako Vi ili Vaše dijete uzmete više lijeka Slenyto nego što ste trebali Ako ste Vi/Vaše dijete slučajno uzeli previše lijeka, obratite se liječniku ili ljekarniku što je prije moguće.
English: 3 years (PVC/PVDC blister and HDPE bottle)
Croatian: 3 godine (PVC/PVDC blister i HDPE bočica)
English: Children's Global Assessment Scale; SE = standard error
Croatian: Children's Global Assessment Scale - Ljestvica opće procjene djece; SE = standardna pogreška; nz = nije značajno
English: However as melatonin is mainly eliminated via liver metabolism, and the metabolite 6SMT is inactive, renal impairment is not expected to influence clearance of melatonin.
Croatian: Međutim, budući da se melatonin uglavnom eliminira putem metabolizma jetre i da metabolit 6-SMT nije aktivan, ne očekuje se da će oštećenje funkcije bubrega utjecati na klirens melatonina.
English: Combination with thioridazine and imipramine should be avoided.
Croatian: Kombinaciju s tioridazinom i imipraminom potrebno je izbjegavati.
English: The effect of any stage of renal impairment on melatonin pharmacokinetics has not been studied.
Croatian: Učinak bilo kojeg stupnja oštećenja funkcije bubrega na farmakokinetiku melatonina nije ispitan.
English: The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP.
Croatian: Nositelj odobrenja obavljat će zadane farmakovigilancijske aktivnosti i intervencije, detaljno objašnjene u dogovorenom planu upravljanja rizikom (RMP), koji se nalazi u modulu 1.8.2. odobrenja za stavljanje lijeka u promet, te svim sljedećim dogovorenim ažuriranim verzijama RMP-a.
English: (used to induce sleep)
Croatian: (koriste se za usnivanje)
English: No clinically significant pharmacokinetic interactions were found in each case.
Croatian: Ni u jednom slučaju nisu utvrđene klinički značajne farmakokinetičke interakcije.
English: Plasma melatonin levels in patients with cirrhosis were significantly increased during daylight hours.
Croatian: Razine melatonina u plazmi u bolesnika s cirozom bile su znatno povišene tijekom dana.
English: • quinolones (for example ciprofloxacin and norfloxacin) and rifampicin (used in the treatment of bacterial infections)
Croatian: • kinoloni (na primjer ciprofloksacin i norfloksacin) i rifampicin (koriste se za liječenje bakterijskih infekcija)
English: Slenyto is for use in the treatment of insomnia.
Croatian: Slenyto se primjenjuje u liječenju nesanice.
English: The in vitro plasma protein binding of melatonin is approximately 60%.
Croatian: Vezanje melatonina za proteine plazme in vitro iznosi približno 60%.
English: Warnings and precautions Talk to your doctor or pharmacist before taking Slenyto if you or your child:
Croatian: Upozorenja i mjere opreza Obavijestiti svojeg liječnika ili ljekarnika prije nego što uzmete lijek Slenyto ako Vi ili Vaše dijete:
English: A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE Name and address of the manufacturer(s) responsible for batch release Iberfar Indústria Farmacêutica S.A.,
Croatian: PROIZVOĐAČ(I) ODGOVORAN(NI) ZA PUŠTANJE SERIJE LIJEKA U PROMET Naziv(i) i adresa(e) proizvođača odgovornog(ih) za puštanje serije u promet Iberfar Indústria Farmacêutica S.A.,
English: Mood swings, Aggression, Irritability
Croatian: Psihijatrijski poremećaji promjene raspoloženja, agresivnost, razdražljivost
English: If any of the following side effects get serious or are troublesome, contact your doctor or seek medical advice:
Croatian: Ako bilo koja od nuspojava navedenih u nastavku postane ozbiljna ili uzrokuje probleme, obratite se svojem liječniku ili potražite liječničku pomoć:
English: As a precautionary measure, it is preferable to avoid the use of melatonin during pregnancy.
Croatian: Kao mjera opreza, preporučuje se izbjegavati primjenu melatonina tijekom trudnoće.
English: - has liver or kidney problems.
Croatian: - imate problema s jetrom ili bubrezima.
English: Data with 2 mg prolonged release melatonin tablets and data with 1 mg and 5 mg mini-tablets indicate that there is no accumulation of melatonin after repeated dosing.
Croatian: Podatci o tabletama melatonina od 2 mg s produljenim oslobađanjem i podatci s mini tabletama od 1 mg i 5 mg ukazuju da se melatonin ne akumulira nakon ponovljenog doziranja.
English: Tablets can be put into food such as yoghurt, orange juice or ice-cream to facilitate swallowing and improve compliance.
Croatian: Tablete se mogu staviti u hranu kao što je jogurt, sok od naranče ili sladoled kako bi se olakšalo gutanje i poboljšala suradljivost.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING
Croatian: PODATCI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU I UNUTARNJEM PAKIRANJU
English: Concomitant use with fluvoxamine, alcohol, benzodiazepines/non-benzodiazepines hypnotics, thioridazine and imipramine is not recommended (see section 4.5).
Croatian: Ne preporučuje se istodobna primjena s fluvoksaminom, alkoholom, benzodiazepinima/nebenzodiazepinskim hipnoticima, tioridazinom i imipraminom (vidjeti dio 4.5).
English: Elimination is by renal excretion of metabolites, 89% as sulfated and glucoronide conjugates of 6-hydroxymelatonin (over 80% as 6-sulfatoxy melatonin) and 2% is excreted as melatonin (unchanged active substance).
Croatian: Eliminacija se odvija izlučivanjem metabolita putem bubrega, od čega se 89% izluči u obliku sulfatnih i glukuronidnih konjugata 6-hidroksimelatonina (preko 80% kao 6-sulfatoksimelatonin), a 2% se izluči u obliku melatonina (neizmijenjena djelatna tvar).
English: However, melatonin co-administration resulted in increased feelings of tranquility and difficulty in performing tasks compared to imipramine alone, and increased feelings of “muzzyheadedness” compared to thioridazine alone.
Croatian: Međutim, istodobna primjena melatonina dovela je do većeg osjećaja smirenosti i poteškoća u obavljanju zadataka u usporedbi sa samim imipraminom te do većeg osjećaja „smušenosti” u usporedbi sa samim tioridazinom.
English: Concomitant use to be considered with caution
Croatian: Istodobna primjena kod koje treba primijeniti oprez
English: There is a significant first pass effect with an estimated first pass metabolism of 85%.
Croatian: Prisutan je značajan učinak prvog prolaska kroz jetru tijekom kojeg se metabolizira oko 85%.
English: Slenyto is a medicine that contains the active ingredient, melatonin.
Croatian: Slenyto je lijek koji sadrži djelatnu tvar melatonin.
English: Melatonin does not induce CYP1A2 or CYP3A enzymes in vitro at supra-therapeutic concentrations.
Croatian: Melatonin ne inducira enzime CYP1A2 ni CYP3A in vitro u supraterapijskim koncentracijama.
English: Tell your doctor or pharmacist before using Slenyto if you or your daughter:
Croatian: Obavijestite svojeg liječnika ili ljekarnika prije nego što uzmete lijek Slenyto ako ste Vi ili Vaša kći:
English: The adjusted estimated treatment differences were 43.2 minutes in the all Randomized Set (MI, p=0 .039).
Croatian: Prilagođena procijenjena razlika između liječenja iznosila je 43,2 minute u cjelokupnoj randomiziranoj populaciji (MI, p=0 ,039).
English: *MMRM analysis CI = confidence interval; WHO-5= the World Health Organization Well-Being Index; CSDI =
Croatian: *MMRM analiza CI = interval pouzdanosti; WHO-5= engl. the World Health Organization Well-Being IndexIndeks dobrobiti prema SZO s 5 pitanja; CSDI = engl.
English: • oestrogens (used in contraceptives or hormone replacement therapy)
Croatian: • estrogeni (koriste se u kontraceptivnim sredstvima ili u hormonskoj nadomjesnoj terapiji)
English: Melatonin may cause drowsiness.
Croatian: Melatonin može uzrokovati omamljenost.
English: Available in bottle packs of 60 tablets and blister packs of 30 / 60 tablets.
Croatian: Dostupne su u bočici sa 60 tableta i blister pakiranjima od 30 / 60 tableta.
English: Both 6hydroxymelatonin and N-acetylserotonin are ultimately conjugated to sulfate and glucoronic acid, and excreted in the urine as their corresponding 6-sulfatoxy and 6-glucoronide derivatives.
Croatian: I 6-hidroksimelatonin i N-acetilserotonin na kraju se konjugiraju sa sulfatom i glukuronskom kiselinom, te se izlučuju u mokraći kao odgovarajući 6-sulfatoksi i 6-glukoronid derivati.
English: Prostaglandin synthesis inhibitors (NSAIDs) such as acetylsalicylic acid and ibuprofen, given in the evening may suppress endogenous melatonin levels in the early part of the night by up to 75%.
Croatian: Inhibitori sinteze prostaglandina (nesteroidni protuupalni lijekovi), kao što su acetilsalicilatna kiselina i ibuprofen, primijenjeni uvečer mogu suzbiti razine endogenog melatonina tijekom ranog dijela noći do 75%.
English: Benzodiazepines/non-benzodiazepine hypnotics
Croatian: Benzodiazepini/nebenzodiazepinski hipnotici
English: Caution should be exercised in patients on 5- or 8-methoxypsoralen (5 or 8-MOP), which increases melatonin levels by inhibiting its metabolism.
Croatian: Potreban je oprez u bolesnika koji uzimaju 5- ili 8-metoksipsoralen (5 ili 8-MOP), koji povećava razine melatonina inhibicijom njegova metabolizma.
English: If the tablets are mixed with food or drink, they should be taken immediately and the mixture not stored.
Croatian: Ako se tablete pomiješaju s hranom ili pićem, potrebno ih je uzeti odmah, te se ta smjesa ne smije čuvati.
English: The whole tablets can be put into food like yoghurt, orange juice or ice-cream to help with swallowing.
Croatian: Cijele tablete moguće je staviti u hranu kao što je jogurt, sok od naranče ili sladoled kako bi ih bilo lakše progutati.
English: Melatonin's metabolism is mainly mediated by CYP1A enzymes.
Croatian: Metabolizam melatonina uglavnom je posredovan CYP1A enzimima.
English: If a tablet is forgotten, it could be taken before the patient goes to sleep that night, but after this time, no other tablet should be given before the next scheduled dose.
Croatian: Ako bolesnik zaboravi uzeti tabletu, može je uzeti prije spavanja te noći, no nakon toga drugu tabletu ne smije uzeti prije sljedeće doze prema rasporedu.
English: The site of biotransformation is the liver.
Croatian: Biotransformacija se odvija u jetri.
English: CARTON (BOTTLE AND BLISTER PACKS) AND LABEL (HDPE BOTTLE) - 5 MG
Croatian: KUTIJA (BOČICA I BLISTER PAKIRANJA) I NALJEPNICA (HDPE BOČICA) - 5 MG
English: Combination with benzodiazepines and non-benzodiazepine hypnotics should be avoided.
Croatian: Kombinaciju s benzodiazepinima i nebenzodiazepinskim hipnoticima potrebno je izbjegavati.
English: Read all of this leaflet carefully before you or your child starts taking this medicine because it contains important information.
Croatian: Vi ili Vaše dijete počnete uzimati ovaj lijek jer sadrži Vama važne podatke.
English: 5 mg strength
Croatian: Jačina: 5 mg
English: If you or your child forgets to take a tablet, it could be taken before going to sleep that night, but after this time, no other tablet should be taken before the next evening.
Croatian: Ako Vi ili Vaše dijete zaboravite uzeti lijek Slenyto Ako Vi ili Vaše dijete zaboravite uzeti tabletu, možete je uzeti prije odlaska na spavanje te noći, no ako je prošlo to vrijeme, ne smijete uzeti drugu tabletu prije sljedeće večeri.
English: The recommended starting dose is 2 mg of Slenyto.
Croatian: Preporučena početna doza je 2 mg lijeka Slenyto.