FrancophonIA/ELRC3.0 huggingface dataset:
English: The most important serious adverse reactions identified in the RCC or STS studies were transient ischaemic attack, ischaemic stroke, myocardial ischaemia, myocardial and cerebral infarction, cardiac dysfunction, gastrointestinal perforation and fistula, QT prolongation, Torsade de Pointes and pulmonary, gastrointestinal and cerebral haemorrhage, all adverse reactions being reported in <1% of treated patients.
Danish: De vigtigste alvorlige bivirkninger identificeret i RCC- eller STS-studierne var transitorisk iskæmisk attak, iskæmisk apopleksi, myokardieiskæmi, myokardieinfarkt og cerebralt infarkt, kardiel dysfunktion, gastrointestinale perforationer og fistler, QT-forlængelse, Torsade de Pointes samt pulmonal, gastrointestinal og cerebral blødning.
English: Blood pressure diastolic increased Blood pressure systolic increased
Danish: Forhøjet systolisk blodtryk
English: Interstitial lung disease/pneumonitis†
Danish: Sjælden Interstitiel lungesygdom/pneumonitis†
English: Capsule-shaped, pink, film-coated tablet with GS JT debossed on one side.
Danish: Kapselformet, lyserød, filmovertrukken tablet med GS JT præget på den ene side.
English: Common side effects (may affect up to 1 in 10 people): - indigestion, bloating, flatulence - nose bleed - dry mouth or mouth ulcers - infections - abnormal drowsiness - difficulty sleeping - chest pain, shortness of breath, leg pain, and swelling of the legs/feet.
Danish: Almindelige bivirkninger (kan forekomme hos op til 1 ud af 10 personer): - fordøjelsesbesvær, oppustethed, luft i maven - næseblod - mundtørhed eller sår i munden - infektioner - unormal døsighed - søvnproblemer - brystsmerter, åndenød, smerter i benene og hævede ben/fødder.
English: Abdominal pain, abdominal pain upper and abdominal pain lower b Oedema, oedema peripheral, eye oedema, localised oedema and face oedema c
Danish: Abdominalsmerter og smerter i den øvre og nedre del af abdomen b Ødem, perifert ødem, øjenødem, lokaliseret ødem og ansigtsødem c
English: Blood creatinine increased
Danish: Forhøjet kreatininniveau i blodet
English: Each film-coated tablet contains 200 mg pazopanib (as hydrochloride).
Danish: Hver filmovertrukken tablet indeholder 200 mg pazopanib (som hydrochlorid).
English: Enterocutaneous fistula
Danish: Enterokutane fistler
English: In vitro studies suggested that the oxidative metabolism of pazopanib in human liver microsomes is mediated primarily by CYP3A4, with minor contributions from CYP1A2 and CYP2C8.
Danish: Resultater fra in vitro-forsøg tyder på, at den oxidative metabolisering af pazopanib i humane levermikrosomer primært medieres af CYP3A4, mens CYP1A2 og CYP2C8 spiller en mindre rolle.
English: Each Votrient 400 mg film-coated tablet contains 400 mg pazopanib.
Danish: Hver Votrient 400 mg filmovertrukken tablet indeholder 400 mg pazopanib.
English: Pazopanib should be used with caution in patients at risk for GI perforation or fistula.
Danish: Pazopanib skal anvendes med forsigtighed til patienter med risiko for gastrointestinale perforationer eller fistler.
English: Hot flush Venous thromboembolic event g
Danish: Almindelig Hedeture Venøse tromboemboliske bivirkninger g
English: Breast-feeding should be discontinued during treatment with pazopanib.
Danish: Amning skal ophøre under behandling med pazopanib.
English: Reversal of effects of TMA has been observed after treatment was discontinued.
Danish: Der er set reversibilitet af TMA efter seponering.
English: Concurrent administration of pazopanib (400 mg once daily) with the strong CYP3A4 and P-gp inhibitor ketoconazole (400 mg once daily) for 5 consecutive days resulted in a 66% and 45% increase in mean pazopanib AUC(0-24) and Cmax, respectively, relative to administration of pazopanib alone (400 mg once daily for 7 days).
Danish: Samtidig administration af pazopanib (400 mg én gang daglig) og den kraftige CYP3A4- og P-gphæmmer ketoconazol (400 mg én gang daglig) i 5 på hinanden følgende dage resulterede i en stigning på 66 % og 45 % i middelværdierne af henholdsvis AUC(0-24) og Cmax for pazopanib i forhold til administration af pazopanib alene (400 mg én gang daglig i 7 dage).
English: Each Votrient 200 mg film-coated tablet contains 200 mg pazopanib.
Danish: Hver Votrient 200 mg filmovertrukken tablet indeholder 200 mg pazopanib.
English: Approximately half of all patients had 3 or more organs involved in their disease and most patients had the lung (74%), and/or lymph nodes (54%) as a metastatic location for disease at baseline.
Danish: Hos ca. halvdelen af patienterne fandtes organinvolvering i tre eller flere organer, primært i form af spredning til lungerne (74 %) og/eller til lymfeknuderne
English: - if you have thyroid problems.
Danish: - hvis du har problemer med skjoldbruskkirtlen.
English: surround and protect the organs.
Danish: fedtvæv eller andre væv, som findes rundt om og beskytter organerne.
English: Very common Tumour pain
Danish: Meget almindelig Tumorsmerte
English: Pazopanib should be used with caution in patients who are at increased risk of thrombotic events or who have had a history of thrombotic events.
Danish: Pazopanib skal anvendes med forsigtighed til patienter med øget risiko for trombotiske hændelser eller med trombotiske hændelser i anamnesen.
English: Pazopanib is an orally administered, potent multi-target tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptors (VEGFR) -1, -2, and -3, platelet-derived growth factor (PDGFR) -α and -β, and stem cell factor receptor (c-KIT), with IC50 values of 10, 30, 47, 71, 84 and 74 nM, respectively.
Danish: Pazopanib hæmmer følgende receptorer: VEGF-receptorer (VEGFR) -1, -2 og -3, trombocytafledte vækstfaktor-receptorer (PDGFR) -α og -β, og stamcellefaktor-receptorer (c-Kit) med IC50-værdier på henholdsvis 10, 30, 47, 71, 84 og 74 nM. I prækliniske forsøg hæmmede pazopanib på dosisafhængig vis den ligandinducerede autofosforylering af receptorerne VEGFR-2, c-Kit og PDGFR-β i celler.
English: Signs and symptoms may include: - bruising easily - high blood pressure - fever - confusion - drowsiness - seizures (fits) - decrease in urine output
Danish: Tegn og symptomer kan omfatte: - tendens til blå mærker - højt blodtryk - feber - forvirring - døsighed - krampeanfald - nedsat produktion af urin
English: The median overall survival (OS) data at the protocol-specified final survival analysis were 22.9 months and 20.5 months [HR = 0.91 (95% CI: 0.71, 1.16; p = 0.224)] for patients randomised to the pazopanib and placebo arms, respectively.
Danish: Ved den protokolbestemte endelige analyse af den samlede overlevelse (OS) var den mediane OS 22,9 måneder for patienter, der var randomiseret til pazopanib-armen, og 20,5 måneder for patienter i placebo-armen [HR = 0,91 (95 % konfidensinterval: 0,71-1,16; p = 0,224)].
English: OD - once daily
Danish: Anbefales ikke x 1 - én gang daglig
English: - Use a reliable method of contraception while you're taking Votrient, and at least for 2 weeks after, to prevent pregnancy.
Danish: - Brug sikker prævention for at undgå at blive gravid, mens du er i behandling med Votrient og i mindst 2 uger efter behandlingen.
English: All patients should have liver function tests to determine whether they have hepatic impairment before starting and during pazopanib therapy (see section 4.4).
Danish: Alle patienter skal have taget prøver for nedsat leverfunktion før og under behandling med pazopanib (se pkt.
English: Transaminase elevations >3 x ULN concurrently with bilirubin elevations >2 x ULN
Danish: Forhøjede aminotransferaser >3 gange den øvre normalgrænse samtidig med forhøjet bilirubin >2 gange den øvre normalgrænse
English: Your doctor will be checking your liver enzymes while you are taking Votrient.
Danish: Din læge vil kontrollere dine leverenzymer, mens du tager Votrient.
English: Blood thyroid stimulating hormone increased
Danish: Forhøjet niveau af thyroideastimulerende hormon i blodet
English: Based on the diminished exposure and limited hepatic reserve pazopanib is not recommended in patients with severe hepatic impairment (defined as total bilirubin >3 X ULN regardless of any level of ALT) (see section 4.2).
Danish: Baseret på den reducerede eksponering og begrænsede leverkapacitet anbefales pazopanib ikke til patienter med svært nedsat leverfunktion (defineret som total-bilirubin >3 gange den øvre normalgrænse uanset ALAT-niveau) (se pkt.
English: In repeat dose studies in rodents, effects in a variety of tissues (bone, teeth, nail beds, reproductive organs, haematological tissues, kidney and pancreas) appear related to the pharmacology of VEGFR inhibition and/or disruption of VEGF signalling pathways, with most effects occurring at plasma exposure levels below those observed in the clinic.
Danish: I forsøg med gentagne doser hos gnavere sås en sammenhæng mellem påvirkningen af forskellige væv (knogler, tænder, neglelejer, reproduktive organer, hæmatologiske væv, nyrer og pankreas) og farmakologien af VEGFR-hæmning og/eller afbrydelse af VEGF-signalering.
English: It should be taken without food, at least one hour before or two hours after a meal (see section 5.2).
Danish: Det må ikke indtages med føde og skal tages mindst 1 time før eller 2 timer efter et måltid (se pkt.
English: Figure 4 Kaplan-Meier Curve for progression-free survival by independent assessment for the overall population (VEG108844)
Danish: Figur 4 Kaplan-Meier-kurve som illustrerer progressionsfri overlevelse bedømt ved en uafhængig vurdering af den samlede patientpopulation (VEG108844)
English: Very common side effects (may affect more than 1 in 10 people): - high blood pressure - diarrhoea - feeling or being sick (nausea or vomiting) - stomach pain - loss of appetite - weight loss - taste disturbance or loss of taste - sore mouth - headache - tumour pain - lack of energy, feeling weak or tired - changes in hair colour - unusual hair loss or thinning - loss of skin pigment
Danish: Meget almindelige bivirkninger (kan forekomme hos flere end 1 ud af 10 personer): - højt blodtryk - diarré - kvalme eller opkastning - mavesmerter - appetitløshed - vægttab - smagsforstyrrelser eller ingen smagssans - ømhed i munden - hovedpine - tumorsmerte - manglende energi, følelse af svaghed eller træthed
English: The maximally tolerated pazopanib dose (MTD) in patients with moderate hepatic impairment (defined as an elevation of bilirubin >1.5 x to 3 x ULN regardless of the ALT values) was 200 mg once daily.
Danish: Den maksimalt tolererede pazopanibdosis hos patienter med moderat nedsat leverfunktion (defineret som forhøjet bilirubin >1,5-3 gange den øvre normalgrænse uanset ALAT-niveau) var 200 mg én gang daglig.
English: Take it at least two hours after a meal or one hour before a meal (see section 3).
Danish: Votrient skal tages mindst 1 time før et måltid eller 2 timer efter et måltid (se punkt 3).
English: Alanine aminotransferase increased
Danish: QT-forlængelse Forhøjet aminotransferaseniveau
English: Continue on pazopanib with weekly monitoring of liver function until transaminases return to Grade 1 or baseline.
Danish: Kontroller leverfunktionen ugentligt, indtil aminotransferase-niveauet vender tilbage til grad 1 eller udgangsniveauet.
English: Electrocardiogram QT prolonged
Danish: Nedsat trombocyttal QT-forlængelse
English: Pruritus generalised 2 (<1%) Rash generalised Rash papular
Danish: Generaliseret pruritus 2 (<1 %) 1 (<1 %) 0 Generaliseret udslæt
English: 800 mg pazopanib once daily is the recommended dose in patients with mild abnormalities in serum liver tests (defined either as normal bilirubin and any degree of alanine aminotransferase (ALT) elevation or as an elevation of bilirubin (>35% direct) up to 1.5 x upper limit of normal (ULN) regardless of the ALT value).
Danish: 800 mg pazopanib én gang daglig er den anbefalede dosis til patienter med let afvigende leverfunktionsprøver målt i serum (defineret enten som normalt bilirubin-niveau og alle grader af forhøjet alaninaminotransferase (ALAT) eller forhøjet bilirubin-niveau (>35 % konjugeret) op til 1,5 gange den øvre normalgrænse uanset ALATniveau).
English: 800 mg OD
Danish: 800 mg x 1
English: Hyperhydrosis Nail disorder
Danish: Hyperhidrose Sygdom i neglene Pruritus
English: You will be checked for any heart problems while you are taking Votrient.
Danish: Du vil blive undersøgt for hjerteproblemer, mens du er i behandling med Votrient.
English: Skin hypopigmentation Dry skin
Danish: Almindelig Hypopigmentering af huden
English: Cerebrovascular accident
Danish: Cerebralt infarkt
English: Figure 5 Kaplan-Meier Curve for Progression-Free Survival in STS by Independent Assessment for the Overall Population (VEG110727)
Danish: Figur 5 Kaplan-Meier-kurve som illustrerer progressionsfri overlevelse ved STS bedømt ved en uafhængig vurdering af den samlede patientpopulation (VEG110727)
English: Administration of pazopanib to patients with mild or moderate hepatic impairment should be undertaken with caution and close monitoring of tolerability.
Danish: Der skal udvises forsigtighed ved administration af pazopanib til patienter med let til moderat nedsat leverfunktion, og patienterne skal monitoreres nøje for tolerabilitet.
English: Uncommon Menorrhagia Vaginal haemorrhage 3 (<1%) Metrorrhagia
Danish: Vaginal blødning 3 (<1 %) 0 Metrorragi
English: The median steady-state pazopanib Cmax and AUC(0-24) in patients with mild abnormalities in hepatic parameters (defined as either normal bilirubin and any degree of ALT elevation or as an elevation of bilirubin up to 1.5 x ULN regardless of the ALT value) after administration of 800 mg once daily are similar to the median in patients with normal hepatic function (see Table 7).
Danish: Median steady-state pazopanib Cmax og AUC(0-24) hos patienter med let afvigende leverparametre (defineret som enten normalt bilirubin-niveau og alle grader af forhøjet ALAT eller forhøjet bilirubin-niveau op til 1,5 gange den øvre normalgrænse uanset ALAT-niveau) efter administration af 800 mg pazopanib én gang daglig, svarede til medianen hos patienter med normal leverfunktion (se tabel 7).
English: Studies in animals have shown reproductive toxicity (see section 5.3).
Danish: Reproduktionstoksicitet er påvist i dyreforsøg (se pkt.
English: The median steady-state Cmax and AUC(0-24) values after administration of 200 mg pazopanib once daily in patients with moderate hepatic impairment were approximately 44% and 39%, of the corresponding median values after administration of 800 mg once daily in patients with normal hepatic function, respectively (see Table 7).
Danish: Medianværdier for steady-state Cmax og AUC(0-24) efter administration af 200 mg pazopanib én gang daglig til patienter med moderat nedsat leverfunktion var henholdsvis ca. 44 % og 39 % af de tilsvarende medianværdier efter administration af 800 mg én gang daglig til patienter med normal leverfunktion (se tabel 7).
English: Pazopanib resulted in an increase of approximately 30% in the mean AUC and Cmax of midazolam (CYP3A4 probe substrate) and increases of 33% to 64% in the ratio of dextrometrophan to dextrophan concentrations in the urine after oral administration of dextromethorphan (CYP2D6 probe substrate).
Danish: Endvidere sås stigninger på 33 % til 64 % i forholdet mellem koncentrationen af dextromethorphan og dextrorphan i urinen efter oral administration af dextromethorphan (CYP2D6-substrat).
English: If you take more Votrient than you should
Danish: Hvis du har taget for meget Votrient
English: Hypothyroidism
Danish: Hypomagnesiæmi
English: g Cardiac dysfunction events - includes Left ventricular dysfunction, Cardiac failure and Restrictive cardiomyopathy h Frequency is based on adverse events reported by investigators.
Danish: g Kardiel dysfunktion - inkluderer venstre ventrikel dysfunktion, hjerteinsufficiens og restriktiv kardiomyopati h
English: In clinical studies with pazopanib, events of cardiac dysfunction such as congestive heart failure and decreased LVEF have occurred (see section 4.8).
Danish: Hændelser med kardiel dysfunktion, såsom kongestiv hjerteinsufficiens og nedsat LVEF, er set i kliniske studier med pazopanib (se pkt 4.8).
English: 800 mg pazopanib once daily is the recommended dose in patients with mild abnormalities in serum liver tests (either normal bilirubin and any degree of ALT elevation or elevation of bilirubin up to 1.5 x ULN regardless of the ALT value).
Danish: 800 mg pazopanib én gang daglig er den anbefalede dosis til patienter med let afvigende leverfunktionsprøver målt i serum (enten normalt bilirubin-niveau og alle grader af forhøjet ALAT eller forhøjet bilirubin op til 1,5 gange den øvre normalgrænse uanset ALAT-niveau).
English: The following terms have been combined: a Abdominal pain, abdominal pain upper and gastrointestinal pain b Oedema, oedema peripheral and eyelid oedema c
Danish: Abdominalsmerter, smerter i den øvre del af abdomen og gastrointestinale smerter b Ødem, perifert ødem og øjenlågsødem c
English: Because the mechanism of action of pazopanib can severely affect organ growth and maturation during early post-natal development in rodents (see section 5.3), pazopanib should not be given to paediatric patients younger than 2 years of age.
Danish: Da pazopanib på grund af virkningsmekanismen i alvorlig grad påvirker organvækst og udvikling i den tidlige post-natale periode hos gnavere (se pkt.
English: Response rate (CR+PR) % (95% CI) Duration of response Median (weeks) (95% CI) 38.9 (16.7, 40.0)
Danish: Responsrate (CR+PR) % (95 % konfidensinterval) Responsvarigheden Median (uger) (95 % konfidensinterval)
English: Myocardial dysfunction occurred in 13% (47/362) of subjects in the pazopanib arm compared to 11% (42/369) of subjects in the sunitinib arm. Congestive heart failure was observed in 0.5% of subjects in each treatment arm. Congestive heart failure was reported in 3 out of 240 subjects (1%) in the Phase III VEG110727 STS study.
Danish: Myokardiel dysfunktion forekom hos 13 % (47/362) af patienterne i pazopanib-armen sammenlignet med 11 % (42/369) af patienterne i sunitinib-armen.
English: Soft-tissue sarcoma (STS)
Danish: Bløddelssarkom (STS)
English: The median steady-state Cmax and AUC(0-24) values after administration of 200 mg pazopanib once daily in patients with severe hepatic impairment were approximately 18% and 15%, of the corresponding median values after administration of 800 mg once daily in patients with normal hepatic function.
Danish: Medianværdier for steady-state Cmax og AUC(0-24) efter administration af 200 mg pazopanib én gang daglig til patienter med svært nedsat leverfunktion var henholdsvis ca. 18 % og 15 % af de tilsvarende medianværdier efter administration af 800 mg én gang daglig til patienter med normal leverfunktion (se tabel 3).
English: OS = overall survival * Overall survival for the respective STS histological subgroups (leiomyosarcoma, synovial sarcoma and “Other” STS) should be interpreted with caution due to the small number of subjects and wide confidence intervals
Danish: HR = hazard ratio; ITT = intent to treat; PFS = progressionsfri overlevelse; CR = komplet respons; PR = delvist respons; OS = samlet overlevelse *Samlet overlevelse ved de respektive histologiske STS-undertyper (leiomyosarkom, synovialsarkom og “andre” STS) skal tolkes med forsigtighed på grund af det lille antal forsøgspersoner og det store konfidensinterval.
English: 30 film-coated tablets 60 film-coated tablets
Danish: 30 filmovertrukne tabletter 60 filmovertrukne tabletter
English: Baseline and periodic evaluation of LVEF is recommended in patients at risk of cardiac dysfunction.
Danish: Det anbefales at måle LVEF inden behandlingsstart og periodisk under behandlingen hos patienter med risiko for kardiel dysfunktion.
English: Patients developing TMA should permanently discontinue treatment with pazopanib.
Danish: Patienter, som udvikler TMA, skal seponere pazopanib permanent.
English: Normal hepatic function
Danish: Normal leverfunktion
English: Pazopanib is not recommended in patients with severe hepatic impairment (defined as total bilirubin >3 x ULN regardless of the ALT value).
Danish: Pazopanib anbefales ikke til patienter med svært nedsat leverfunktion (defineret som total-bilirubin >3 gange den øvre normalgrænse uanset ALAT-niveauet).
English: In clinical studies with pazopanib, proteinuria has been reported.
Danish: Proteinuri er rapporteret i kliniske studier med pazopanib.
English: Transaminase elevation of >8 x ULN
Danish: Forhøjede aminotransferaser >8 gange den øvre normalgrænse
English: In clinical studies with pazopanib, myocardial infarction, myocardial ischaemia, ischaemic stroke and transient ischaemic attack were observed (see section 4.8).
Danish: Myokardieinfarkt, myokardieiskæmi, iskæmisk apopleksi og transitorisk iskæmisk attak er observeret i kliniske studier med pazopanib (se pkt.
English: There is no specific antidote for overdose with pazopanib and treatment of overdose should consist of general supportive measures.
Danish: Der findes ingen specifik antidot, som kan anvendes i tilfælde af overdosering med pazopanib.
English: Common Abdominal distension 16 (4%) Dry mouth
Danish: Udspilet abdomen 36 (3 %) Sår i munden
English: Gastrointestinal haemorrhage
Danish: Gastrointestinal blødning
English: What Votrient looks like and contents of the pack Votrient 200 mg film-coated tablets are capsule-shaped, pink with “GS JT” marked on one side.
Danish: Votrient 200 mg filmovertrukne tabletter er kapselformede og lyserøde med “GS JT” trykt på den ene side.
English: Decreases in LVEF in subjects who had post-baseline and follow-up LVEF measurement were detected in 11% (15/140) in the pazopanib arm, compared with 3% (1/39) in the placebo arm.
Danish: Nedsat LVEF sås hos 11 % (11/140) og 3 % (1/39) i henholdsvis pazopanib-armen og placebo-armen hos de forsøgspersoner, der fik målt LVEF post baseline og ved followup.
English: Therefore, pazopanib should be administered at least two hours after food or at least one hour before food (see section 4.2).
Danish: Derfor skal pazopanib administreres mindst 1 time før eller 2 timer efter et måltid (se pkt.
English: Cerebral infarction 1 (<1%)
Danish: Øsofagal blødning 1 (<1 %) 0
English: Pre-clinical studies in animals have shown reproductive toxicity (see section 5.3).
Danish: Reproduktionstoksicitet er påvist i prækliniske dyreforsøg (se pkt.
English: In clinical studies with pazopanib, increase in serum transaminases (ALT, aspartate aminotransferase [AST]) and bilirubin were observed (see section 4.8).
Danish: En stigning i serumniveauet af aminotransferaser (ALAT, aspartataminotransferase [ASAT]) og bilirubin er observeret i kliniske studier med pazopanib (se pkt.
English: Common Musculoskeletal pain 35 (9%) Myalgia Muscle spasms Uncommon Arthralgia
Danish: Almindelig Muskuloskeletale smerter 35 (9 %) 2 (<1 %) 0 Myalgi
English: x axis; Months, y axis; Proportion Progression Free, Pazopanib --- (N = 290) Median 9.2 months; Placebo ------- (N = 145) Median 4.2 months; Hazard Ratio = 0.46, 95% CI (0.34, 0.62), P <0.0000001
Danish: X-akse: Måneder, Y-akse: Progressionsfri overlevelse, Pazopanib --- (n = 290), median 9,2 måneder; Placebo ------- (n = 145), median 4,2 måneder; Hazard ratio = 0,46; 95 % konfidensinterval (0,34-0,62), P < 0,0000001
English: You will be checked for thyroid hormone levels while you are taking Votrient.
Danish: Du vil blive undersøgt for mængden af skjoldbruskkirtelhormon i blodet, mens du er i behandling med Votrient.
English: x axis; Months, y axis; Proportion Progression Free, Pazopanib --- (N = 155) Median 11.1 months; Placebo -------- (N = 78) Median 2.8 months; Hazard Ratio = 0.40, 95% CI (0.27, 0.60), P <0.0000001
Danish: X-akse: Måneder, Y-akse: Progressionsfri overlevelse, Pazopanib --- (n = 155), median 11,1 måneder; Placebo ------- (n = 78), median 2,8 måneder; Hazard ratio = 0,40; 95 % konfidensinterval (0,27-0,60), P < 0,0000001
English: Concomitant use of pazopanib and simvastatin increases the risk of ALT elevations (see section 4.5) and should be undertaken with caution and close monitoring.
Danish: Samtidig brug af pazopanib og simvastatin øger risikoen for stigning i ALAT-niveauet (se pkt.