FrancophonIA/ELRC3.0 huggingface dataset:
English: From clinical study and post marketing data there are no indications that the safety profile is different in different subsets of the paediatric population or different from the safety profile in adult patients.
Slovenian: Iz kliničnih študij in iz podatkov v obdobju trženja zdravila se pri nobeni indikaciji ne pokaže različen varnostni profil pri različnih podskupinah pediatričnih bolnikov ali drugačen varnostni profil glede na odrasle bolnike.
English: A population pharmacokinetic analysis has been conducted on a group of 207 HT-1 patients.
Slovenian: Populacijske farmakokinetične analize so bile izvedene na skupini 207 bolnikov s HT-1.
English: Orfadin is also available as a 4 mg/ml oral suspension for paediatric patients who have difficulties swallowing capsules.
Slovenian: Zdravilo Orfadin je na voljo tudi kot 4 mg/ml peroralna suspenzija za pediatrične bolnike, ki imajo težave pri požiranju kapsul.
English: What Orfadin is and what it is used for
Slovenian: Kaj je zdravilo Orfadin in za kaj ga uporabljamo
English: What Orfadin is and what it is used for What you need to know before you take Orfadin How to take Orfadin
Slovenian: Kaj je zdravilo Orfadin in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Orfadin Kako jemati zdravilo Orfadin
English: Age at onset of symptoms 1 year 2 years < 2 months > 2-6 months > 6 months
Slovenian: Starost pri pojavu simptomov 1 leto 2 leti < 2 meseca > 2-6 mesecev > 6 mesecev
English: Oral suspension 90 ml
Slovenian: peroralna suspenzija 90 ml
English: Orfadin may interfere with the effect of other medicines, such as: - Medicines for epilepsy (such as phenytoin) - Medicines against blood clotting (such as warfarin)
Slovenian: Zdravilo Orfadin lahko vpliva na delovanje drugih zdravil, kot so: - zdravila za epilepsijo (kot je fenitoin) - zdravila proti strjevanju krvi (kot je varfarin)
English: Do not attach a needle to the syringe.
Slovenian: Na brizgo ne pritrdite igle.
English: The dose recommendation in mg/kg body weight is the same in children and adults.
Slovenian: Pediatrična populacija Priporočeni odmerek v mg/kg telesne mase je enak za otroke in odrasle.
English: It is recommended that the oral suspension is taken with food.
Slovenian: Priporočljivo je, da se peroralna suspenzija jemlje s hrano.
English: It is important that you use the correct oral syringe when taking the medicine.
Slovenian: Pomembno je, da uporabite pravo brizgo za peroralno dajanje , ko vzamete zdravilo.
English: Follow-up by your doctor should be performed every 6 months.
Slovenian: Vsakih 6 mesecev mora zdravnik opraviti kontrolni pregled.
English: Other medicines and Orfadin
Slovenian: Druga zdravila in zdravilo Orfadin
English: Age at start of treatment 2 years 4 years 6 years
Slovenian: Starost na začetku zdravljenja 2 leti 4 leta 6 let
English: If you start treatment by taking it with food, it is recommended that you carry on taking it with food throughout your course of treatment.
Slovenian: Če boste zdravljenje začeli z jemanjem tega zdravila s hrano je priporočljivo, da tako nadaljujete ves čas zdravljenja.
English: How to prepare a dose of medicine
Slovenian: Kako pripraviti odmerek zdravila
English: Increase in serum alpha-fetoprotein concentration may be a sign of inadequate treatment.
Slovenian: Povečanje koncentracije alfa-fotoproteina je lahko znak neustreznega zdravljenja.
English: The bottle adapter should not be removed.
Slovenian: Nastavek za steklenico se ne sme odstraniti.
English: This is because the oral syringe which is used to withdraw the correct dose from the bottle is marked in ml.
Slovenian: To pa zato, ker ima brizga za peroralno dajanje, ki se uporablja za odvzem pravilnega odmerka iz steklenice, oznake v ml.
English: No information about specific treatment of overdose is available.
Slovenian: Ni podatkov o specifičnosti zdravljenja v primeru prevelikega odmerjanja.
English: Food does not influence the bioavailability of nitisinone oral suspension, but intake together with food decreases the absorption rate and consequently leads to lower fluctuations in serum concentrations within a dosage interval.
Slovenian: Hrana ne vpliva na biološko uporabnost peroralne suspenzije nitizinona, vendar jemanje skupaj s hrano zmanjša hitrost absorpcije in posledično povzroči nižje fluktuacije v serumskih koncentracijah znotraj intervala odmerjanja.
English: Pharmacotherapeutic group: Other alimentary tract and metabolism products, Various alimentary tract and metabolism products, ATC code: A16A X04.
Slovenian: Farmakoterapevtska skupina: Druga zdravila za bolezni prebavil in presnove, razna zdravila za bolezni prebavil in presnove, oznaka ATC: A16A X04.
English: Contents of the pack and other information What Orfadin contains
Slovenian: Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Orfadin
English: Your doctor, pharmacist or nurse will advise which oral syringe to use depending on the dose that has been prescribed.
Slovenian: Zdravnik, farmacevt ali medicinska sestra vam bodo svetovali, katero brizgo za peroralno dajanje uporabite, glede na odmerek, ki vam je bil predpisan.
English: Orfadin blocks the breakdown of tyrosine and the harmful substances are not formed.
Slovenian: Zdravilo Orfadin zaustavi razgraditev tirozina in prepreči nastanek škodljivih snovi.
English: If the vision is affected the patient should not drive or use machines until the event has subsided.
Slovenian: Če je prizadet vid, naj bolnik ne vozi in ne upravlja strojev, dokler neželen učinek ne izzveni.
English: 2 mg: Store in a refrigerator.
Slovenian: 2 mg: Shranjujte v hladilniku.
English: The bottle may be stored at a temperature not above 25°C or in the refrigerator.
Slovenian: Steklenica se lahko shranjuje pri temperaturi do 25 °C ali v hladilniku.
English: What you need to know before you take Orfadin Do not take Orfadin
Slovenian: Kaj morate vedeti, preden boste vzeli zdravilo Orfadin Ne jemljite zdravila Orfadin
English: The bottle may be stored at room temperature (not above 25°C).
Slovenian: Steklenico lahko shranjujete pri sobni temperaturi (do 25 °C).
English: Do not breast-feed while taking this medicine, see section “Do not take Orfadin”.
Slovenian: Med jemanjem tega zdravila ne smete dojiti, glejte poglavje »Ne jemljite zdravila Orfadin«.
English: The newborn baby's blood levels of bilirubin (a substance that causes the yellowing of the skin in high levels) will be closely monitored.
Slovenian: Novorojenčkove ravni bilirubina (snovi, ki povzroča porumenelost kože in visoke ravni) v krvi bodo natančno spremljali.
English: It is important to carefully follow the instructions given in section 6.6 for preparation and administration of the dose, in order to ensure the dosing accuracy.
Slovenian: Pomembno je, da se točno upošteva navodila, dana v poglavju 6.6, za pripravo in dajanje odmerka, da se zagotovi natančnost odmerjanja.
English: The dose should be administered in the mouth immediately (without dilution) in order to avoid caking in the oral syringe.
Slovenian: Odmerek je treba dati v usta takoj (brez redčenja), da se prepreči strjevanje v peroralni brizgi.
English: The adverse reactions listed below by MedDRA system organ class and absolute frequency, are based on data from a clinical trial and post-marketing use.
Slovenian: Neželeni učinki, ki so navedeni spodaj in so razvrščene na podlagi organskih sistemov in absolutne pogostnosti, temeljijo na podatkih iz kliničnega preskušanja in uporabe v obdobju trženja.
English: Each pack contains 1 bottle.
Slovenian: Eno pakiranje vsebuje 1 plastenko.
English: Remove the bottle from the refrigerator.
Slovenian: Vzemite steklenico iz hladilnika.
English: Each bottle contains 90 ml oral suspension.
Slovenian: Vsaka steklenica vsebuje 90 ml peroralne suspenzije.
English: HDPE bottle with a tamper-proof closure of LDPE, containing 60 capsules.
Slovenian: Plastenka iz HDPE z zaščitno zaporko iz LDPE, ki vsebuje 60 kapsul.
English: Do not throw away any medicines via wastewater or household waste.
Slovenian: Zdravila ne smete odvreči v odpadne vode ali md gospodinjske odpadke.
English: Do not use this medicine after the expiry date which is stated on the bottle and the carton after “EXP”.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na plastenki in škatli poleg oznake »EXP«.
English: A close monitoring of the plasma levels of bilirubin in the newborn patient is therefore of great importance.
Slovenian: Pri novorojenih bolnikih je zato zelo pomembno natančno spremljanje ravni bilirubina v plazmi.
English: Orfadin with food
Slovenian: Zdravilo Orfadin skupaj s hrano
English: Shake off excess water and leave the disassembled oral syringe to dry until reassemble for next dosing occasion.
Slovenian: Odvečno vodo otresite in pustite razstavljeno brizgo za peroralno dajanje, da se suši, dokler je spet ne sestavite za naslednji odmerek.
English: During regular monitoring, it is appropriate to follow urine succinylacetone, liver function test values and alpha-fetoprotein levels (see section 4.4).
Slovenian: Med rednim nadzorovanjem je treba spremljati sukcinilaceton v urinu, teste delovanja jeter in raven alfa-fetoproteina (glejte poglavje 4.4).
English: Precautions to be taken before handling or administering the medicinal product No needle, intravenous tubing or any other device for parenteral administration should be attached to the oral syringe.
Slovenian: Previdnostni ukrepi, potrebni pred ravnanjem z zdravilom ali dajanjem zdravila Na brizgo za peroralno dajanje ne smejo biti pritrjene igle, intravenski infuzijski sistemi ali katere koli druge naprave za parenteralno dajanje.
English: Sodium benzoate (E211) Citric acid monohydrate Sodium citrate
Slovenian: Natrijev benzoat (E211) Citronska kislina monohidrat Natrijev citrat
English: Place the open bottle upright on a table.
Slovenian: Postavite odprto steklenico v pokončnem položaju na mizo.
English: The oral syringe must be emptied slowly to allow swallowing; rapid squirting of the medicine may cause choking.
Slovenian: Brizgo za peroralno dajanje je treba izprazniti počasi, da se omogoči požiranje; hitro brizganje zdravila lahko povzroči davljenje.
English: Before shaking the bottle, it may look like a solid cake in the bottom and a slightly opalescent liquid.
Slovenian: Preden steklenico pretresete, je lahko videti kot trdna usedlina na dnu in rahlo motna tekočina.
English: Orfadin is for oral use only.
Slovenian: Zdravilo Orfadin je samo za peroralno uporabo.
English: The capsules are packaged in plastic bottles with tamper-proof closures.
Slovenian: Kapsule so pakirane v plastenkah z zaščitno zaporko.
English: If the levels are markedly higher than they should be, especially in prematures babies with risk factors as acidosis (too low pH in the blood) and low albumin level (a protein in the blood) treatment with Orfadin capsules will be considered instead of the oral suspension until the bilirubin plasma levels are normalised.
Slovenian: Če so ravni znatno višje, kot bi smele biti, zlasti pri nedonošenčkih z dejavniki tveganja, kot sta acidoza (prenizka vrednost pH v krvi) in nizko ravnijo albumina (beljakovina v krvi) bodo razmislili o zdravljenju z zdravilom Orfadin v obliki kapsul namesto s peroralno suspenzijo, dokler se ravni bilirubina v plazmi ne normalizirajo.
English: A dose of 20 ml oral suspension (10 g glycerol) or more may cause headache, stomach upset and diarrhoea.
Slovenian: Odmerek 20 ml peroralne suspenzije (10 g glicerola) ali več lahko povzroči glavobol, želodčne motnje in drisko.
English: In patients with HT-1, these intermediates are converted to the toxic metabolites succinylacetone and succinylacetoacetate.
Slovenian: Pri bolnikih s HT-1 se ta intermediata pretvorita v toksična presnovka sukcinilaceton in sukcinilacetoacetat.
English: Therefore, mothers receiving nitisinone must not breast-feed, since a risk to the suckling child cannot be excluded (see sections 4.3 and 5.3).
Slovenian: Matere, ki jemljejo Orfadin, ne smejo dojiti, ker tveganja za dojenčka ni mogoče izključiti (glejte poglavji 4.3 in 5.3).
English: It is used for measuring doses of more than 3 ml.
Slovenian: Uporablja se za merjenje odmerkov, večjih od 3 ml.
English: Restriction of tyrosine and phenylalanine in the diet should limit the toxicity associated with this type of tyrosinemia by lowering tyrosine levels (see section 4.4).
Slovenian: Omejitev tirozina in fenilalanina v dieti bi morala omejiti toksičnost, ki je povezana s tem tipom tirozinemije z zniževanjem ravni tirozina (glejte poglavje 4.4).
English: It is recommended that the healthcare professional advises the patient or carer giver how to use the oral syringes to ensure that the correct volume is administered.
Slovenian: Priporoča se, da zdravstveni delavec svetuje bolniku ali negovalcu, kako uporabljati brizge za peroralno dajanje, da se zagotovi dajanje pravilne količine.
English: Push the plastic adapter firmly into the neck of the bottle as far as you can (figure C) and close the bottle with the child resistant screw cap.
Slovenian: Čvrsto potisnite plastični nastavek na vrat steklenice, kolikor se da (slika C) in zaprite steklenico z za otroke varno navojno zaporko.
English: The safety profile is mainly based on the paediatric population since nitisinone treatment should be started as soon as the diagnosis of hereditary tyrosinemia type 1 (HT-1) has been established.
Slovenian: Varnostni profil v glavnem temelji na pediatričnih bolnikih, ker je treba zdravljenje z nitizinonom začeti takoj, ko je ugotovljena diagnoza dedne tirozinemije tipa 1 (HT-1).
English: Strawberry aroma (artificial) Purified water
Slovenian: Jagodna aroma (umetna)
English: Orfadin is also available in 2 mg, 5 mg, 10 mg and 20 mg capsules, if considered more suitable for the patient.
Slovenian: Zdravilo Orfadin je na voljo tudi v obliki 2 mg, 5 mg, 10 mg in 20 mg kapsul, če je to za bolnika bolj ustrezno.
English: The bottle should be removed from the refrigerator, and the date when the bottle is removed from the refrigerator should be noted on the bottle label.
Slovenian: Steklenico je treba vzeti iz hladilnika in datum, ko je bila steklenica vzeta iz hladilnika, zabeležiti na nalepko na steklenici.
English: Bilirubin levels should be measured before start of treatment: in case of markedly elevated plasma levels of bilirubin, especially in premature patients with risk factors as acidosis and low albumin level, treatment with an appropriately weighed portion of an Orfadin capsule should be considered instead of the oral suspension until the unconjugated bilirubin plasma levels are normalised.
Slovenian: Ravni bilirubina je treba izmeriti pred začetkom zdravljenja: pri znatno povečanih ravneh bilirubina v plazmi, zlasti pri bolnikih nedonošenčkih z dejavniki tveganja, kot sta acidoza in nizka raven albumina, je treba razmisliti o zdravljenju z ustrezno odmerjenim delom kapsule zdravila Orfadin namesto peroralne suspenzije, dokler se ravni nekonjugiranega bilirubina v plazmi ne normalizirajo.
English: Based on in vitro studies, nitisinone is not expected to inhibit CYP1A2, 2C19 or 3A4-mediated metabolism or to induce CYP1A2, 2B6 or 3A4/5.
Slovenian: Študije in vitro so pokazale, da nitizonon ne bi smel zavirati presnove, ki deluje preko encimov CYP 1A2, 2C19 ali 3A4, ali inducirati encimov CYP 1A2, 2B6 ali 3A4/5.
English: Each ml contains 500 mg. A dose of 20 ml oral suspension (10 g glycerol) or more may cause headache, stomach upset and diarrhoea.
Slovenian: En ml vsebuje 500 mg. Odmerek 20 ml peroralne suspenzije (10 g glicerola) ali več lahko povzroči glavobol, želodčne motnje in drisko.
English: For subsequent dosing see the instructions below ‘How to prepare a dose of medicine'
Slovenian: Za nadaljnje odmerjanje glejte navodila spodaj: "Kako pripraviti odmerek zdravila"
English: A 1 ml, 3 ml and 5 ml oral syringes are included in the pack to measure the dose in ml in accordance with the prescribed posology.
Slovenian: V pakiranju so priložene 1 ml, 3 ml in 5 ml brizge za peroralno dajanje za merjenje odmerka v ml v skladu s predpisanim odmerjanjem.
English: If your prescription is in mg, contact your pharmacist or doctor for advice.
Slovenian: Če je vaš recept v mg, se posvetujte s farmacevtom ali zdravnikom.
English: Orfadin has minor influence on the ability to drive and use machines.
Slovenian: Zdravilo Orfadin ima blag vpliv na sposobnost vožnje in upravljanja strojev.
English: It is recommended that the healthcare professional advises the patient or care giver how to use the oral syringes to ensure that the correct volume is administered and that the prescription is given in ml.
Slovenian: Priporoča se, da zdravstveni delavec svetuje bolniku ali negovalcu, kako uporabljati brizge za peroralno dajanje, da se zagotovi dajanje pravilne količine, in da je recept v mililitrih.
English: Probability of no HCC (95% confidence interval) at start
Slovenian: Verjetnost za nepojav HCK (95 % interval zaupanja) po na začetku po 2 letih po 4 letih po 6 letih
English: What Orfadin looks like and contents of the pack
Slovenian: Izgled zdravila Orfadin in vsebina pakiranja
English: Nitisinone treatment should be initiated and supervised by a physician experienced in the treatment of HT-1 patients.
Slovenian: Zdravljenje z nitizinonom mora začeti in nadzorovati zdravnik, usposobljen za zdravljenje bolnikov s HT-1.
English: Hydroxypropylmethylcellulose Glycerol
Slovenian: Hidroksipropil metilceluloza Glicerol
English: The active ingredient of Orfadin is nitisinone.
Slovenian: Zdravilna učinkovina v zdravilu Orfadin je nitizinon.
English: 100 ml brown glass bottle (type III) with a white child-resistant HDPE screw cap with sealing and tamper evidence.
Slovenian: 100 ml rjava steklenica (tip III) z belo za otroke varno navojno zaporko iz HDPE in varnostnim zapiralom.
English: Orfadin contains sodium, glycerol and sodium benzoate
Slovenian: Zdravilo Orfadin vsebuje natrij, glicerol in natrijev benzoat
English: Excipients with known effect: Each ml contains: sodium 0.7 mg (0.03 mmol) glycerol 500 mg sodium benzoate 1 mg
Slovenian: En ml vsebuje: natrij 0,7 mg (0,03 mmol) glicerol 500 mg natrijev benzoat 1 mg
English: How to take Orfadin
Slovenian: Kako jemati zdravilo Orfadin
English: Dose Orfadin mg ml
Slovenian: Odmerek zdravila Orfadin mg ml
English: Clean the oral syringe immediately with water.
Slovenian: Brizgo za peroralno dajanje je treba takoj očistiti z vodo.
English: Before you take the first dose, shake the bottle vigorously since during long-term storage the particles will form a solid cake at the bottom of the bottle.
Slovenian: Preden vzamete prvi odmerek, steklenico močno pretresite, ker med dolgotrajnim shranjevanjem iz delcev nastane trdna usedlina na dnu steklenice.
English: The bottle should be shaken vigourously for at least 5 seconds (Figure D).
Slovenian: Steklenico je treba močno stresati najmanj 5 sekund (slika D).
English: Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2)
Slovenian: Predpisovanje in izdaja zdravila je le s posebnim režimom (Glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2)
English: Therefore, it is recommended that the oral suspension is taken with food, see section 4.2.
Slovenian: Zato se priporoča jemanje peroralne suspenzije s hrano, glejte poglavje 4.2.
English: A patient displaying visual disorders during treatment with nitisinone should without delay be examined by an ophthalmologist.
Slovenian: Če se pri bolniku med zdravljenjem z nitizinonom pojavijo motnje vida, mora nemudoma na okulistični pregled.
English: If you have taken more of this medicine than you should, contact your doctor or pharmacist as soon as possible.
Slovenian: Če ste vzeli večji odmerek zdravila Orfadin, kot bi smeli Če ste vzeli prevelik odmerek tega zdravila, se čim prej posvetujte z zdravnikom ali farmacevtom.
English: Separate barrel and plunger and rinse both with water.
Slovenian: Ločite telo in bat in oba splaknite z vodo.
English: 2 mg, 5 mg, 10 mg and 20 mg hard capsules:
Slovenian: 2 mg, 5 mg, 10 mg in 20 mg trde kapsule:
English: Read the package leaflet carefully before use.
Slovenian: Pred uporabo natančno preberite priloženo navodilo!
English: It is recommended that the oral suspension is taken with food, see section 4.5.
Slovenian: Priporočljivo je, da se peroralna suspenzija jemlje s hrano, glejte poglavje 4.5.
English: Do not forget to mark the date on the bottle, when removed from the refrigerator.
Slovenian: Ne pozabite na vsebniku označiti datuma, ko ste zdravilo vzeli iz hladilnika.
English: A pre- and postnatal development study in the mouse showed statistically significantly reduced pup survival and pup growth during the weaning period at dose levels 125- and 25-fold higher, respectively, than the maximum recommended human dose, with a trend toward a negative effect on pup survival starting from the dose of 5 mg/kg/day.
Slovenian: Študije o pre- in postnatalnem razvoju pri miših so pokazale statistično značilno zmanjšano preživetje mladičev, izpostavljenih 125-krat večjim odmerkom, in zmanjšanje rasti mladičev po odstavitvi pri 25-krat večjih odmerkih v primerjavi z največjim priporočenim odmerkom za človeka.
English: Sodium benzoate may increase jaundice (yellowing of the skin and eyes) in pre-term and full-term jaundiced neonates and develop into kernicterus (brain damage due to deposits of bilirubin in the brain).
Slovenian: Natrijev benzoat lahko okrepi zlatenico (porumenelost kože in oči) pri nedonošenčkih in pri donošenih novorojenčkih z zlatenico in se razvije v kernikterus (poškodba možganov zaradi usedlin bilirubina v možganih).
English: White, slightly viscous opaque suspension.
Slovenian: peroralna suspenzija Bela, rahlo viskozna motna suspenzija.
English: This medicinal product contains 0.7 mg (0.03 mmol) sodium per ml.
Slovenian: To zdravilo vsebuje 0,7 mg (0,03 mmol) natrija na ml.
English: Nitisinone plasma concentration reached in clinical setting is not expected to inhibit OATP1B1, OATP1B3 mediated transport.
Slovenian: Ni pričakovati, da bi koncentracija nitizinona v plazmi, dosežena v kliničnem okolju, zavirala transport, ki deluje preko OATP1B1,
English: Always use one of the oral syringes provided to take the medicine.
Slovenian: Za jemanje zdravila vedno uporabite eno od priloženih brizg za peroralno dajanje.
English: The open bottle should be placed upright on a table, and the plastic adapter pushed firmly into the neck of the bottle as far as possible (Figure C).
Slovenian: Odprto steklenico je treba pokonci postaviti na mizo in plastični nastavek čvrsto potisniti v vrat steklenice, kolikor se da (slika C).
English: Each pack contains one bottle, one bottle adapter and three oral syringes.
Slovenian: Eno pakiranje vsebuje eno steklenico, en nastavek za steklenico in tri brizge za peroralno dajanje.
English: Before re-dispersion, the medicinal product may appear as a solid cake with a slightly opalescent supernatant.
Slovenian: Pred redisperzijo ima lahko zdravilo obliko trdne pogače z blago motnim supernatantom.
English: The oral suspension is taken with a oral syringe directly in the mouth without dilution.
Slovenian: Peroralna suspenzija se jemlje z brizgo za peroralno dajanje neposredno v usta brez redčenja.
English: Shake the bottle vigorously for at least 5 seconds (figure D).
Slovenian: Močno stresajte steklenico najmanj 5 sekund (slika D).
English: There are no specific dose recommendations for elderly or patients that have renal or hepatic impairment.
Slovenian: Posebne skupine bolnikov Za starejše bolnike ali bolnike z ledvično ali jetrno okvaro ni posebnih priporočil glede odmerjanja.
English: Before taking the first dose, the bottle should be shaken vigorously since during long-term storage the particles will form a solid cake at the bottom of the bottle.
Slovenian: Pred prvim odmerkom je treba steklenico močno pretresti, ker med dolgotrajnim shranjevanjem iz delcev nastane trdna pogača na dnu steklenice.
English: The bottle should be turned to an upright position again, and the oral syringe disconnected by gently twisting it out of the bottle.
Slovenian: Steklenico je treba obrniti nazaj v pokončen položaj, nato pa se brizga za peroralno dajanje izvleče tako, da se jo nežno zasuče iz steklenice.