FrancophonIA/ELRC3.0 huggingface dataset:
English: Cydectin TriclaMox (5 mg/ml and 200 mg/ml) pour-on solution for cattle is a veterinary medicinal product containing 5 mg moxidectin per ml and 200 mg triclabendazole per ml.
Slovenian: Cydectin TriclaMox (5 mg/ml in 200 mg/ml) raztopina za kožni poliv za govedo je zdravilo za uporabo v veterinarski medicini, ki vsebuje 5 mg moksidektina na ml in 200 mg triklabendazola na ml.
English: The procedure was thus referred to the Co-ordination Group for Mutual Recognition and Decentralised Procedures-Veterinary (CMD(v)) under Article 13(1) of Commission Regulation (EC) No 1234/2008 on 11 December 2012 by the RMS (France).
Slovenian: Zato je 11. decembra 2012 referenčna država članica (Francija) postopek napotila na Usklajevalno skupino za postopek z medsebojnim priznavanjem in decentralizirani postopek - zdravila za uporabo v veterinarski medicini (CMD(v)) v skladu s členom 13(1) Uredbe Komisije (ES) št.
English: Opinion following an Article 131 referral for Cydectin TriclaMox (5 mg/ml and 200 mg/ml) pour-on solution for cattle
Slovenian: za zdravilo Cydectin TriclaMox (5 mg/ml in 200 mg/ml) raztopina za kožni poliv za govedo
English: The differences were not statistically significant.
Slovenian: Razlike niso bile statistično značilne.
English: This could be dangerous to yourself or others.
Slovenian: Pri tem lahko ogrozite sebe ali druge.
English: Date of first authorisation: 18 September 2014 Date of latest renewal: 08 July 2019
Slovenian: Datum prve odobritve: 18. september 2014 Datum zadnjega podaljšanja: 8. julij 2019
English: The recommended starting dose should not be exceeded.
Slovenian: Priporočenega začetnega odmerka se ne sme prekoračiti.
English: How much solution is left?
Slovenian: Koliko raztopine je še preostalo?
English: Choose a time of the day that works best for you.
Slovenian: Izberite čas dneva, ki vam najbolj ustreza.
English: This is especially important if you take more than one type of injectable medicine.
Slovenian: To je še posebej pomembno, če uporabljate več kot le eno zdravilo za injiciranje.
English: One study was further extended to 52 weeks.
Slovenian: Eno študijo so podaljšali na 52 tednov.
English: The relevance for humans is likely to be low but cannot be completely excluded.
Slovenian: Pomen tega za človeka je verjetno majhen, vendar pa ga ni mogoče povsem izključiti.
English: These may be signs of a very serious condition called ‘ketoacidosis'.
Slovenian: To so lahko znaki zelo resnega stanja, ki ga imenujemo “ketoacidoza”.
English: Do not give this medicine to children or adolescents.
Slovenian: Tega zdravila ne dajajte otrokom ali mladostnikom.
English: Before opening
Slovenian: Pred prvim odprtjem
English: • not give you any food or drink - because you may choke.
Slovenian: • ne smejo pa vam dajati hrane ali pijače, saj se lahko zadušite.
English: CI: 95% confidence interval.
Slovenian: 95 % interval zaupanja.
English: GLP-1 is a physiological regulator of appetite and food intake, but the exact mechanism of action is not entirely clear.
Slovenian: GLP-1 je fiziološki regulator apetita in vnosa hrane, vendar pa natančen mehanizem delovanja ni v celoti znan.
English: Local tolerance was assessed in rabbits and pigs.
Slovenian: Lokalno toleranco so vrednotili pri kuncih in prašičih.
English: 4.5 Interaction with other medicinal products and other forms of interaction
Slovenian: 4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Farmakodinamične interakcije
English: • how to adjust the dose.
Slovenian: • kako prilagoditi odmerek.
English: 2 Check the flow
Slovenian: 2 Preverite pretok
English: ATC code: A10AE56
Slovenian: Oznaka ATC: A10AE56.
English: • how much Xultophy you will need each day
Slovenian: • koliko zdravila Xultophy boste uporabili vsak dan,
English: Do not cover it with your fingers.
Slovenian: Ne dotikajte se ga s prsti,
English: These tumours were not seen in monkeys treated for 20 months.
Slovenian: Teh tumorjev niso opazili pri opicah, ki so jih zdravili 20 mesecev.
English: • a reminder of the need to report all medication errors irrespective of whether or not they resulted in an adverse event.
Slovenian: • opomnik, da je treba poročati o vseh napakah, povezanih z uporabo zdravila, ne glede na to, če se je posledično pojavil neželeni učinek ali ne.
English: The MAH shall agree the final content and modality of distribution for the educational materials together with a communication plan, with the National Competent Authority in each Member State prior to distribution of the educational materials in the Member State.
Slovenian: Imetnik dovoljenja za promet bo končno besedilo in način distribucije izobraževalnega gradiva ter načrt komuniciranja v državi članici uskladil v dogovoru s pristojnim nacionalnim organom v vsaki državi članici pred distribucijo izobraževalnega gradiva.
English: The duration of observation was minimum 3.5 years and up to a maximum of 5 years.
Slovenian: 3,5 leta in do največ 5 let.
English: These reactions were usually mild and transitory and they normally disappear during continued treatment.
Slovenian: Te reakcije so bile običajno blage in prehodne, med nadaljevanjem zdravljenja pa so običajno izzvenele.
English: Tell your doctor if you are pregnant, think you might be pregnant or are planning to have a baby.
Slovenian: Obvestite zdravnika, če ste noseči, menite, da bi lahko bili noseči ali načrtujete zanositev.
English: You should therefore monitor your blood sugar level more often than usual.
Slovenian: Koncentracijo krvnega sladkorja morate zato kontrolirati bolj pogosto kot običajno.
English: What others need to do if you pass out:
Slovenian: Kaj morajo storiti drugi, če se onesvestite
English: Time since Randomisation (Week)
Slovenian: Čas od randomizacije (teden)
English: Use in elderly patients (65 years old or over)
Slovenian: Uporaba pri starejših bolnikih (starih 65 let ali starejših)
English: The efficacy and safety of Xultophy were sustained up to 52 weeks of treatment.
Slovenian: Učinkovitost in varnost zdravila Xultophy sta se ohranili do 52. tedna zdravljenja.
English: The educational materials should contain: - Summary of product characteristics and package leaflet; - Healthcare professional brochure that should contain the following key elements:
Slovenian: Izobraževalno gradivo mora vsebovati: - povzetek glavnih značilnosti zdravila in navodilo za uporabo, - brošuro za zdravstvene delavce, ki bo vsebovala naslednje ključne navedbe:
English: A minimum of 8 hours between injections should always be ensured.
Slovenian: Zagotoviti je treba, da med posameznima injiciranjima vedno mine najmanj 8 ur.
English: Liraglutide (Victoza)
Slovenian: Liraglutid (Victoza)
English: No interaction study has been performed.
Slovenian: Študije medsebojnega delovanja niso izvedli.
English: The proportion of patients reporting nausea per week at any point during treatment was below 4%.
Slovenian: Delež bolnikov, ki so poročali o navzei, je bil manjši od 4 % v vsakem tednu zdravljenja.
English: This is usually only short-lasting.
Slovenian: To običajno kmalu mine.
English: This may constitute a risk in situations where these abilities are of special importance (e.g. driving a car or using machines).
Slovenian: To lahko predstavlja tveganje pri dejavnostih, pri katerih so takšne sposobnosti še posebej pomembne (npr.
English: • you have had low blood sugar a few times recently.
Slovenian: • ste pred kratkim imeli večkrat prenizek krvni sladkor.
English: Change the needle as described in section 5 and repeat all steps starting with section 1: Prepare your pen with a new needle.
Slovenian: Zamenjajte iglo, kot je opisano pod točko 5, in ponovite vse korake, začenši s točko 1, “Pripravite injekcijski peresnik z novo injekcijsko iglo”.
English: Taking the wrong medicine could be harmful to your health.
Slovenian: Z uporabo napačnega zdravila lahko ogrozite svoje zdravje.
English: • have eye problems.
Slovenian: • če imate težave z očmi.
English: Pay special attention to these notes as they are important for safe use of the pen.
Slovenian: Upoštevajte te opombe, ker so pomembne za varno uporabo injekcijskega peresnika.
English: Dose counter stopped: 42 dose steps left
Slovenian: števec odmerka se je ustavil: preostalo je še 42 odmernih korakov
English: After first opening: Use within 21 days
Slovenian: Po prvem odprtju: porabite v 21 dneh.
English: • if you are allergic to insulin degludec or liraglutide or any of the other ingredients of this medicine (listed in section 6).
Slovenian: • če ste alergični na insulin degludek, liraglutid ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
English: It is therefore recommended that the patient always carries sugar-containing products
Slovenian: Priporočljivo je, da ima bolnik vedno pri sebi živila, ki vsebujejo sladkor.
English: No data is available beyond 52 weeks of treatment.
Slovenian: Podatki o zdravljenju, daljšem od 52 tednov, niso na voljo.
English: Detailed instructions for use are on the other side of this leaflet.
Slovenian: Podrobna navodila za uporabo so na voljo na drugi strani tega navodila.
English: For study results with respect to combinations, effects on glycaemic control, and the populations studied, see sections 4.4, 4.5 and 5.1.
Slovenian: Za rezultate študij v zvezi s kombinacijami, učinki na urejenost glikemije in skupinami bolnikov, ki so jih preučili, glejte poglavja 4.4., 4.5 in 5.1.
English: Two minor plasma metabolites were detected (≤9% and ≤5% of total plasma radioactivity exposure).
Slovenian: Odkrili so tudi dva manj pomembna presnovka v plazmi (≤ 9 % in ≤ 5 % celotne izpostavljenosti plazme radioaktivnosti).
English: Tell them what could happen if your blood sugar gets low, including the risk of passing out.
Slovenian: Povejte jim kaj se lahko zgodi v primeru prenizkega krvnega sladkorja, vključno s tveganjem, da se onesvestite.
English: The Xultophy clinical development programme included approximately 1,900 patients treated with Xultophy.
Slovenian: V klinični razvojni program zdravila Xultophy je bilo vključenih približno 1.900 bolnikov, ki so se zdravili z zdravilom Xultophy.
English: If no drop appears, repeat steps 2A to 2C up to 6 times.
Slovenian: Če se kapljica ne pojavi, ponovite korake od 2A do 2C, vendar pa ne več kot 6-krat.
English: • other medicines for diabetes (tablets or injections)
Slovenian: • druga zdravila za zdravljenje sladkorne bolezni (tablete ali injekcije),
English: Name and address of the manufacturer of the biological active substances Novo Nordisk A/S
Slovenian: Ime in naslov izdelovalcev biološke učinkovine Novo Nordisk A/S
English: • drink alcohol
Slovenian: • uživate alkohol,
English: After first opening, the medicinal product can be stored for 21 days at a maximum temperature of 30°C.
Slovenian: 2 leti Po prvem odprtju se zdravilo lahko shranjuje 21 dni pri temperaturi do 30 °C.
English: • Serious allergic reaction (anaphylactic reaction) (not known: frequency cannot be estimated from the available data).
Slovenian: • resna alergijska reakcija (anafilaktična reakcija) (pogostnost neznana - pogostnosti iz razpoložljivih podatkov ni mogoče oceniti)
English: If necessary, clean it with mild detergent on a moistened cloth.
Slovenian: Po potrebi ga očistite s krpo, navlaženo z blagim detergentom.
English: Make sure you select the full dose you need.
Slovenian: Poskrbite, da izberete celoten predpisan odmerek.
English: If you discover that you missed your previous dose when it is time to take your next regular scheduled dose, do not take a double dose.
Slovenian: Če ugotovite, da ste pozabili odmerek, ko je že čas za naslednji odmerek, ne uporabite dvojnega odmerka.
English: In both groups 66%-67% achieved HbA1c < 7%.
Slovenian: V obeh skupinah je od 66 % do 67 % bolnikov doseglo vrednosti HbA1c < 7 %.
English: • you have had an injection of glucagon
Slovenian: • ste uporabili injekcijo glukagona,
English: Primary outcome or vital status at end of trial was available for 99.7% and 99.6% of participants randomised to liraglutide and placebo, respectively.
Slovenian: Primarni izid oz. vitalni status na koncu preskušanja je bil na voljo za 99,7 % preiskovancev, ki so prejemali liraglutid, in 99,6 % preiskovancev, ki so prejemali placebo.
English: Liraglutide is a Glucagon-Like Peptide-1 (GLP-1) analogue with 97% sequence homology to human GLP-1 that binds to and activates the GLP-1 receptor (GLP-1R).
Slovenian: Liraglutid je analog glukagonu podobnega peptida-1 (GLP-1) s 97 % sekvenčno homologijo s človeškim GLP-1, ki se veže na receptor za GLP-1 (GLP-1R) in ga aktivira.
English: Before you use Xultophy for the first time, your doctor or nurse will show you how to inject.
Slovenian: Pred prvo uporabo zdravila Xultophy vam bosta zdravnik ali medicinska sestra pokazala, kako injicirati zdravilo.
English: It is unknown whether the reduced pup growth is caused by reduced pup milk intake due to a direct GLP-1 effect or reduced maternal milk production due to decreased caloric intake.
Slovenian: Ni znano, če je bila počasnejša rast mladičev posledica slabšega hranjenja z mlekom zaradi neposrednega vpliva GLP-1 ali posledica manjšega nastajanja mleka pri materi zaradi manjšega kaloričnega vnosa.
English: • danazol - medicine affecting ovulation
Slovenian: • danazol - zdravilo, ki vpliva na ovulacijo,
English: • If the liquid you can see through the pen window does not look clear and colourless.
Slovenian: • če tekočina, ki jo vidite skozi okence injekcijskega peresnika, ni bistra in brezbarvna.
English: • Always follow your doctor's advice for dose and dose adjustment.
Slovenian: • Upoštevajte navodila zdravnika glede odmerka in prilagoditve odmerka.
English: • Test your blood or urine for ketones.
Slovenian: • Določite ketone v krvi ali urinu.
English: • a clear explanation of the posology of the product and the meaning of ‘dose steps' - with reference to dose of each component for each dose step
Slovenian: • jasno razlago odmerjanja zdravila in pomena »odmernih korakov«, s sklicevanjem na odmerjanje vsake od učinkovin za vsak posamezni odmerni korak,
English: The safety and efficacy of Xultophy were evaluated in seven randomised, controlled, parallel group phase 3 trials in different populations of subjects with type 2 diabetes defined by previous antidiabetes treatment.
Slovenian: Varnost in učinkovitost zdravila Xultophy so ocenjevali v sedmih randomiziranih, kontroliranih preskušanjih faze 3 z vzporednimi skupinami z različnimi populacijami oseb s sladkorno boleznijo tipa 2, opredeljenimi glede na predhodno antidiabetično zdravljenje.
English: Turn the dose selector until the dose counter stops.
Slovenian: Zavrtite izbirnik odmerka dokler se števec odmerka ne ustavi.
English: General effects from diabetes treatment
Slovenian: Splošni učinki zaradi zdravljenja sladkorne bolezni
English: If your blood sugar level gets low you may pass out (become unconscious).
Slovenian: Če se koncentracija krvnega sladkorja prekomerno zmanjša, lahko omedlite (postanete nezavestni).
English: • Allergic reactions (hypersensitivity) such as rash, itching and swelling of the face.
Slovenian: • alergijske reakcije (preobčutljivost), kot so izpuščaj, srbenje in otekanje obraza
English: Mean change Estimated difference
Slovenian: Povprečna sprememba Ocenjena razlika
English: In rats, a no observed adverse effect level (NOAEL) was not observed.
Slovenian: Pri podganah niso ugotovili vrednosti brez ugotovljenih neželenih učinkov (NOAEL - No Observed Adverse Effect
English: Important things to know before you use this medicine:
Slovenian: Pomembne stvari, ki jih morate vedeti pred začetkom uporabe tega zdravila Obvestite zdravnika:
English: Do not attach a new needle to your pen until you are ready to take your injection.
Slovenian: Ne pritrjujte nove igle na injekcijski peresnik, dokler niste pripravljeni na injiciranje zdravila.
English: Ask your doctor whether you can drive if:
Slovenian: Posvetujte se z zdravnikom, če lahko upravljate vozila in stroje, v primeru da:
English: Animal studies did not indicate direct harmful effects with respect to fertility but slightly increased early embryonic deaths at the highest dose.
Slovenian: Študije na živalih sicer niso pokazale neposrednih škodljivih vplivov na plodnost, vendar pa so pri največjem odmerku ugotovili nekoliko povečano zgodnjo umrljivost zarodkov.
English: This also applies when administration at the same time of the day is not possible.
Slovenian: To velja tudi v primerih, ko bolnik zdravila ne more uporabljati vsak dan ob istem času.
English: If you use basal insulin
Slovenian: Če uporabljate bazalni insulin
English: Insulin degludec (Tresiba)
Slovenian: Insulin degludek (Tresiba)
English: During 24 hours following administration of a single radiolabelled [3H]-liraglutide dose to healthy subjects, the major component in plasma was intact liraglutide.
Slovenian: V 24 urah po aplikaciji enkratnega odmerka z radioaktivnim izotopom označenega [3H]-liraglutida zdravim osebam je bila glavna komponenta v plazmi nespremenjeni liraglutid.
English: The half-life of insulin degludec is approximately 25 hours and the half-life of liraglutide is approximately 13 hours.
Slovenian: Izločanje Razpolovni čas insulina degludek je približno 25 ur, razpolovni čas liraglutida pa približno 13 ur.
English: • you find it hard to recognise low blood sugar.
Slovenian: • težko prepoznate znake prenizkega krvnega sladkorja.
English: The long-term improvements in blood sugar control may ease the eye problems.
Slovenian: Dolgotrajno izboljšanje urejenosti krvnega sladkorja pa težave z očmi lahko ublaži;
English: Interaction studies did not show any clinically relevant delay of absorption.
Slovenian: Študije medsebojnega delovanja niso pokazale, da bi bila upočasnitev absorpcije klinično pomembna.
English: A. MANUFACTURER OF THE BIOLOGICAL ACTIVE SUBSTANCES AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Slovenian: A. IZDELOVALCI BIOLOŠKE UČINKOVINE IN IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ
English: These findings in rodents are caused by a non-genotoxic, specific GLP-1 receptor-mediated mechanism to which rodents are particularly sensitive.
Slovenian: Pri glodavcih so ti učinki posledica negenotoksičnega, specifično preko receptorjev GLP-1 posredovanega mehanizma, za katerega so glodavci zelo občutljivi.
English: *Self-measured plasma glucose.
Slovenian: *Samoizmerjena koncentracija glukoze v plazmi.
English: • have or have had a thyroid disease.
Slovenian: • če imate ali ste kdaj imeli bolezen ščitnice.
English: A small drop may remain at the needle tip, but it will not be injected.
Slovenian: Na konici igle lahko ostane majhna kapljica, ki pa ne bo injicirana.
English: The same titration algorithm was applied for basal insulin comparators.
Slovenian: Enak algoritem titriranja je bil uporabljen za primerjalne bazalne insuline.
English: • have not used enough Xultophy, keep using less Xultophy than you need, forget to use Xultophy or stop using Xultophy without talking to your doctor.
Slovenian: • niste uporabili dovolj zdravila Xultophy, uporabljate manjši odmerek zdravila Xultophy, kot ga potrebujete, ste pozabili uporabiti zdravilo Xultophy ali prenehate uporabljati zdravilo Xultophy, ne da bi se prej o tem posvetovali s svojim zdravnikom.
English: If you select a wrong dose, you can turn the dose selector forward or backward to the correct dose.
Slovenian: Če izberete napačen odmerek, lahko z vrtenjem izbirnika odmerka naprej ali nazaj izberete pravilen odmerek.
English: No other treatment-related tumours have been found.
Slovenian: Drugih z zdravljenjem povezanih tumorjev niso ugotovili.
English: A clinically relevant interaction with active substances with poor solubility or with narrow therapeutic index such as warfarin cannot be excluded.
Slovenian: Klinično pomembnega medsebojnega delovanja z učinkovinami s slabo topnostjo in ozkim terapevtskim indeksom, kot je varfarin, ni mogoče izključiti.
English: • If you are given glucagon, you will need sugar or a sugary snack as soon as you come round.
Slovenian: • Če boste prejeli injekcijo glukagona, boste morali zaužiti sladkor ali sladek prigrizek, takoj ko se zaveste.
English: It is prescribed when these medicines (used alone or with GLP-1 treatment or with basal insulin) are not enough to control your blood sugar levels.
Slovenian: Predpisuje se, če ta zdravila (sama ali skupaj z agonistom receptorjev GLP-1 ali bazalnim insulinom) ne zadostujejo za ureditev koncentracije krvnega sladkorja.
English: Alcohol may intensify or reduce the hypoglycaemic effect of Xultophy.
Slovenian: Alkohol lahko okrepi ali zmanjša hipoglikemični učinek zdravila Xultophy.
English: For frequencies of hypoglycaemia, please see section 5.1.
Slovenian: Za pogostnost hipoglikemij glejte poglavje 5.1.
English: They may make it harder to recognise the warning signs of low blood sugar (see section 4 ‘Warning signs of low blood sugar - these may come on suddenly')
Slovenian: Ta zdravila lahko otežijo prepoznavanje opozorilnih znakov prenizkega krvnega sladkorja (glejte poglavje 4, podpoglavje “Opozorilni znaki prenizkega krvnega sladkorja - lahko se pojavijo nenadoma”);
English: Look through the pen window.
Slovenian: Poglejte skozi okence injekcijskega peresnika.
English: Xultophy can be used in elderly patients.
Slovenian: Zdravilo Xultophy se lahko uporablja pri starejših bolnikih.
English: Combination of pioglitazone and insulin medicinal products
Slovenian: Kombinacija pioglitazona in insulinskih zdravil
English: Make sure the dose counter shows 2.
Slovenian: Prepričajte se, da števec odmerka kaže 2.
English: The trials were of 26 weeks duration randomising between 199 and 833 patients to Xultophy.
Slovenian: Preskušanja so trajala 26 tednov in na zdravilo Xultophy je bilo randomiziranih od 199 do 833
English: Upon initiation of Xultophy treatment in patients on warfarin or other coumarin derivatives more frequent monitoring of INR (International Normalised Ratio) is recommended.
Slovenian: Po uvedbi zdravljenja z zdravilom Xultophy je pri bolnikih, ki se zdravijo z varfarinom ali drugimi kumarinskimi derivati, priporočljivo pogosteje nadzirati vrednost mednarodnega normaliziranega razmerja (INR - International Normalised Ratio).
English: Do not use this medicine after the expiry date which is stated on the pen label and carton after ‘EXP'.
Slovenian: Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki injekcijskega peresnika in škatli poleg oznake “Uporabno do” ali “EXP”.
English: In animal studies, peripheral administration of liraglutide led to uptake in specific brain regions involved in regulation of appetite, where liraglutide, via specific activation of the GLP1R, increased key satiety and decreased key hunger signals, thereby leading to lower body weight.
Slovenian: V študijah na živalih je liraglutid po perifernem odmerjanju prešel v dele možganov, ki so vključeni v uravnavanje apetita, kjer je liraglutid prek specifične aktivacije GLP-1R zvišal ključne signale za sitost in zmanjšal ključne signale za lakoto, kar je posledično vodilo v zmanjšanje telesne mase.
English: Xultophy should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Slovenian: Zdravila Xultophy se ne sme uporabljati pri bolnikih s sladkorno boleznijo tipa 1 ali za zdravljenje diabetične ketoacidoze.
English: Improved insulin secretion compared to insulin degludec in response to a standardised meal test was demonstrated in 260 patients with type 2 diabetes after 52 weeks of treatment.
Slovenian: Izboljšanje izločanja insulina v primerjavi z insulinom degludek kot odgovor na test s standardiziranim obrokom je bilo dokazano pri 260 bolnikih s sladkorno boleznijo tipa 2 po 52 tednih zdravljenja.
English: • If you need more medicine than what is left in your pen, you can split your dose between two pens.
Slovenian: • Če potrebujete večjo količino zdravila, kot je preostala v injekcijskem peresniku, lahko odmerek razdelite in ga injicirate z dvema injekcijskima peresnikoma.
English: If you keep injecting in the same place, these changes can become more severe and affect the amount of medicine your body gets from the pen.
Slovenian: Takšne spremembe namreč lahko pri nadaljnjem injiciranju zdravila na isto mesto postanejo hujše in vplivajo na količino zdravila, ki preide v telo.