FrancophonIA/ELRC3.0 huggingface dataset:
English: Ritonavir steady-state pharmacokinetic parameters were evaluated in HIV infected children less than 2 years of age receiving doses ranging from 350 to 450 mg/m2 twice daily.
Croatian: Pokazatelji farmakokinetike ritonavira u stanju dinamičke ravnoteže evaluirani su u bolesnika zaraženih HIV-om mlađih od 2 godine, koji su primali doze u rasponu od 350 do 450 mg/m² dva puta na dan.
English: Increased plasma concentrations of lomitapide (see section 4.5).
Croatian: Povećane koncentracije lomitapida u plazmi (vidjeti dio 4.5)
English: Ritonavir dosed as a pharmacokinetic enhancer
Croatian: Ritonavir doziran kao farmakokinetički pojačivač
English: PDE5 inhibitors
Croatian: Inhibitori PDE5
English: Increased plasma concentrations of quetiapine which may lead to coma.
Croatian: Povišena koncentracija kvetiapina u plazmi može dovesti do kome.
English: Each film-coated tablet contains 87.75 mg of sodium.
Croatian: Pomoćna tvar s poznatim učinkom Jedna filmom obložena tableta sadrži 87,75 mg natrija.
English: 2 Based on cross-study comparison to 1,200 mg amprenavir twice daily alone.
Croatian: Zasniva se na usporedbi među ispitivanjima s 1200 mg amprenavira dva puta na dan, u monoterapiji.
English: Ritonavir steady-state pharmacokinetic parameters were evaluated in HIV infected children above 2 years of age receiving doses ranging from 250 mg/m2 twice daily to 400 mg/m2 twice daily.
Croatian: Pokazatelji farmakokinetike ritonavira u stanju dinamičke ravnoteže evaluirani su u djece zaražene HIV-om starije od 2 godine, koja su primala doze u rasponu od 250 mg/m² dva puta na dan do 400 mg/m² dva puta na dan.
English: • a tingling sensation or numbness in the hands, feet or around the lips and mouth
Croatian: stopalima ili oko usana i ustiju
English: 500q12h,↓ 36% ↓ 38% Increased methadone dose may be necessary when concomitantly administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer due to induction of glucuronidation.
Croatian: 5, jednokratna doza 500 svakih 12 h, ↓ 36% ↓ 38% Zbog indukcije glukuronidacije, može biti potrebno povećati dozu metadona kada se daje istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom ili kao farmakokinetičkim pojačivačem.
English: When ritonavir is used in combination with another protease inhibitor and buprenorphine, the SPC of the co-administered protease inhibitor should be reviewed for specific dosing information.
Croatian: Kada se ritonavir daje u kombinaciji s drugim inhibitorom proteaza i buprenorfinom, specifične informacije o doziranju treba potražiti u SPC-u za drugi inhibitor proteaza.
English: Morphine levels may be decreased due to induction of glucuronidation by co-administered ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer.
Croatian: Razine morfina mogu se sniziti zbog indukcije glukuronidacije pri istodobnoj primjeni ritonavira doziranog kao antiretrovirusnog lijeka ili kao farmakokinetičkog pojačivača.
English: Co-administration of atazanavir with ritonavir at doses greater than 100 mg once daily has not been clinically evaluated.
Croatian: Primjena atazanavira istodobno s ritonavirom u dozama većim od 100 mg jedanput na dan nije klinički evaluirana.
English: Increased plasma concentrations of vardenafil (see sections 4.4. and 4.5).
Croatian: Povišena koncentracija vardenafila u plazmi (vidjeti dio 4.4 i 4.5).
English: 50, oral single dose
Croatian: 50, jednokratna oralna doza
English: Clinical trials confirmed the safety and efficacy of 300 mg atazanavir once daily with ritonavir 100 mg once daily in treatment experienced patients.
Croatian: Klinička su ispitivanja potvrdila neškodljivost i djelotvornost atazanavira u dozi od 300 mg jedanput na dan s ritonavirom u dozi od 100 mg jedanput na dan u liječenju bolesnika koji su već primali terapiju.
English: What Ritonavir Mylan is and what it is used for Ritonavir Mylan contains the active substance ritonavir.
Croatian: Što Ritonavir Mylan sadrži - Djelatna tvar je ritonavir.
English: Darunavir 800 mg once daily with ritonavir 100 mg once daily may be used in some ART experienced patients.
Croatian: Darunavir 800 mg jedanput na dan s ritonavirom 100 mg jedanput na dan može se primjenjivati kod nekih bolesnika koji su prethodno primali ART.
English: What you need to know before you or your child takes Ritonavir Mylan).
Croatian: Što morate znati prije nego što Vi ili Vaše dijete počnete uzimati Ritonavir Mylan).
English: Increased plasma concentrations of venetoclax.
Croatian: Povećane koncentracije venetoklaksa u plazmi.
English: No medicinal product interaction study has been performed for the co-administration of ritonavir with benzodiazepines.
Croatian: Ispitivanje interakcija pri istodobnoj primjeni ritonavira i benzodiazepina nije provedeno.
English: Furthermore, no clinically significant renal abnormalities were noted in clinical trials.
Croatian: Nadalje, u kliničkim ispitivanjima nije bilo klinički značajnih bubrežnih poremećaja.
English: The tablet coating is composed of: hypromellose, titanium dioxide (E171), macrogols, hydroxypropylcellulose, talc, iron oxide yellow (E172), colloidal anhydrous silica, polysorbate
Croatian: Film ovojnica hipromeloza titanijev dioksid (E171) makrogoli hidroksipropilceluloza talk žuti željezov oksid (E172) silicijev dioksid, koloidni, bezvodni polisorbat 80
English: Ritonavir pharmacokinetic parameters have not been studied in patients with renal impairment.
Croatian: Pokazatelji farmakokinetike ritonavira nisu evaluirani u bolesnika s oslabljenom funkcijom bubrega.
English: Dosage reduction of desipramine is recommended when co-administered with ritonavir dosed as an antiretroviral agent.
Croatian: Preporučuje se smanjenje doze dezipramina kada se daje istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom.
English: PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON
Croatian: PODACI KOJI SE MORAJU NALAZITI NA VANJSKOMPAKIRANJU KUTIJA
English: 500 q12 h,
Croatian: 500 svakih 12 h,
English: Thyroid hormone replacement therapy
Croatian: Nadomjesna terapija tireoidnog hormona Levotiroksin
English: Careful monitoring of serum levels or therapeutic effects is recommended when these medicines are concomitantly administered with ritonavir.
Croatian: Preporučuje se pažljivo praćenje njihovih serumskih razina i terapijskih učinaka kada se ti lijekovi primjenjuju istodobno s ritonavirom.
English: Ritonavir medicinal product level decreased Herbal preparation
Croatian: Snižava se razina lijeka koji sadržava ritonavir Biljni pripravci
English: The co-administration of riociguat with ritonavir is not recommended (see section 4.4 and refer to riociguat SmPC).
Croatian: Istodobna primjena riocigvata i ritonavira se ne preporučuje (vidjeti dio 4.4 i Sažetak opisa svojstava lijeka za riocigvat).
English: Life-threatening and fatal drug interactions have been reported in patients treated with colchicine and ritonavir (CYP3A4 and P-gp inhibition) in patients with renal and/or hepatic impairment (see sections 4.3 and 4.4).
Croatian: U bolesnika s oštećenjem funkcije bubrega i/ili jetre liječenih kolhicinom i ritonavirom (inhibicija CYP3A i P-gp) zabilježene su po život opasne i fatalne interakcije lijekova (vidjeti dijelove 4.3 i 4.4).
English: HCV protease inhibitor Simeprevir
Croatian: Inhibitori proteaze HCV-a
English: 100q12h Darunavir
Croatian: 600, jednokratno 100 svakih 12 h Darunavir
English: 100, single dose 500q12h ↑ 11-fold ↑ 4-fold Concomitant use of sildenafil for the treatment of erectile dysfunction with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer should be with caution and in no instance should sildenafil doses exceed 25 mg in 48 hours (see also section 4.4).
Croatian: Pri primjeni sildenafila za liječenje erektilne disfunkcije istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom ili kao farmakokinetičkim pojačivačem nužan je oprez, a sildenafil se ni u kojem slučaju ne smije davati u dozama većima od 25 mg u 48 sati (vidjeti i dio 4.4).
English: What you need to know before you or your child takes Ritonavir Mylan
Croatian: Što morate znati prije nego što Vi ili Vaše dijete počnete uzimati Ritonavir Mylan
English: Concomitant use of ritonavir with lomitapide is contraindicated (see prescribing information for lomitapide) (see section 4.3).
Croatian: Istodobna primjena ritonavira i lomitapida je kontraindicirana (vidjeti sažetak opisa svojstava lijeka za lomitapid) (vidjeti dio 4.3).
English: Concomitant administration of ritonavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity (see section 4.3).
Croatian: Istodobna primjena ritonavira i kvetiapina je kontraindicirana jer može povećati s kvetiapinom povezanu toksičnost (vidjeti dio 4.3). β2-agonist (dugodjelujući)
English: 400q12h ↓ 82% ↓ 66%
Croatian: 400 svakih 12h↓82% ↓ 66%
English: Gradually increasing the dose of ritonavir when initiating therapy may help to improve tolerance.
Croatian: Podnošenje lijeka može se olakšati postupnim povećavanjem doze ritonavira na početku liječenja.
English: How to store Ritonavir Mylan
Croatian: Kako čuvati Ritonavir Mylan
English: Analgesics
Croatian: Analgetici
English: Ritonavir inhibits CYP3A4 and as a result a pronounced increase in the plasma concentrations of salmeterol is expected.
Croatian: Ritonavir inhibira CYP3A4 te se stoga očekuje znatan porast koncentracija salmeterola u plazmi.
English: Colchicine (for gout) as ritonavir may raise the blood levels of this medicine.
Croatian: - Kolhicin (za liječenje gihta) jer ritonavir može povisiti razine ovog lijeka u krvi.
English: Bosentan, riociguat (used for pulmonary arterial hypertension) as ritonavir may increase the blood levels of this medicine.
Croatian: - Bosentan, riocigvat (lijekovi za plućnu arterijsku hipertenziju) jer ritonavir može povisiti razinu tog lijeka u krvi.
English: (See section 4 Possible side effects) Dizziness, lightheadedness, fainting spells or abnormal heartbeat.
Croatian: - Omaglica, ošamućenost, epizode kratkotrajne nesvjestice ili abnormalni otkucaji srca.
English: The other tablet ingredients are: copovidone, sorbitan laurate, colloidal anhydrous silica, sodium chloride, sodium stearyl fumarate see section 2 ‘Ritonavir Mylan contains sodium'.
Croatian: natrijev klorid, natrijev stearilfumarat (vidjeti dio 2 „Ritonavir Mylan sadrži natrij”).
English: Increased plasma concentrations of cisapride.
Croatian: Povećane koncentracije cisaprida u plazmi.
English: Ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer
Croatian: Ritonavir doziran kao antiretrovirusni lijek ili kao farmakokinetički pojačivač
English: Modest prolongation of the PR interval was also noted in subjects receiving ritonavir in the same study on Day 3.
Croatian: U ispitanika koji su primali ritonavir u istom je ispitivanju trećeg dana uočeno i umjereno produženje PR-intervala.
English: Thereby, increasing the risk of serious respiratory depression or haematologic abnormalities, or other serious adverse effects from these agents.
Croatian: Time se povećava rizik od ozbiljne depresije dišnog sustava, hematoloških poremećaja i od ostalih ozbiljnih nuspojava tih lijekova.
English: Inform your doctor as soon as possible if you experience any symptoms that suggest an allergic reaction after taking Ritonavir Mylan such as rash, hives or breathing difficulties.
Croatian: Jave li se pri uzimanju lijeka Ritonavir Mylan bilo koji simptom koji upućuje na alergijsku reakciju, poput osipa, koprivnjače ili otežanog disanja, o tome što prije obavijestite svog liječnika.
English: For further information, refer to the Summary of Product Characteristics for maraviroc.
Croatian: Za daljnje informacije vidjeti Sažetak opisa svojstava lijeka za maravirok.
English: The Day 3 ritonavir exposure was approximately 1.5 fold higher than that observed with the 600 mg twice daily dose at steady state.
Croatian: Izloženost ritonaviru 3. dan ispitivanja bila je, u stanju dinamičke ravnoteže 1,5 puta veća od one pri dozi od 600 mg ritonavira dva puta na dan.
English: Increased plasma concentrations of norpethidine, piroxicam and propoxyphene.
Croatian: Povećane koncentracije norpetidina, piroksikama i propoksifena u plazmi.
English: Ritonavir, co-administration is likely to result in increased plasma concentrations of amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, and quinidine and is therefore contraindicated (see section 4.3).
Croatian: Istodobno primijenjeni ritonavir vjerojatno povećava koncentracije amiodarona, bepridila, dronedarona, enkainida, flekainida, propafenona i kinidina te je stoga je kontraindiciran (vidjeti dio 4.3).
English: ↑ 29 fold ND
Croatian: ↑ 20 do
English: • abnormally heavy periods
Croatian: • neuobičajeno jake menstruacije
English: Uncommon Rare oedema and peripheral oedema, dehydration (usually associated with gastrointestinal symptoms) Diabetes mellitus Hyperglycaemia
Croatian: Hiperkolesterolemija, hipertrigliceridemija, giht, edem i periferni edem, dehidracija (uglavnom povezana sa simptomima od strane probavnog sustava)
English: Antiarrhythmics Amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, quinidine
Croatian: Antiaritmici Amiodaron, bepridil, dronedaron, enkainid, flekainid, propafenon, kinidin
English: ↑ 14 fold
Croatian: ↑ 14 puta
English: Lopinavir co-formulated with ritonavir (lopinavir/ritonavir) 400 mg/100 mg or 800 mg/200 mg. Saquinavir 1,000 mg twice daily with ritonavir 100 mg twice daily in ART experienced patients.
Croatian: Lopinavir u formulaciji s ritonavirom (lopinavir/ritonavir) 400 mg/100 mg ili 800 mg/200 mg.
English: Due to an increased incidence of gastrointestinal and hepatic adverse reactions, a dose reduction of ketoconazole should be considered when co-administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer.
Croatian: Zbog povećane učestalosti nuspojava povezanih s probavnim sustavom i jetrom valja razmotriti smanjivanje doze ketokonazola kada se daje istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom ili kao farmakokinetičkim pojačivačem.
English: In patients with haemophilia type A and B, there have been reports of increased bleeding while taking this treatment or another protease inhibitor.
Croatian: A i B bilo je prijava pojačanog krvarenja za vrijeme uzimanja ovog lijeka ili drugih inhibitora proteaza.
English: Co-administration of fosamprenavir with ritonavir in doses greater than 100 mg twice daily has not been clinically evaluated.
Croatian: Primjena fosamprenavira istodobno s ritonavirom u dozama većim od većim od 100 mg dva puta na dan nije klinički evaluirana.
English: 200 q12 h/6 h after
Croatian: 200 svakih 12 h/6 h kasnije
English: Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent
Croatian: Ritonavir doziran kao farmakokinetički pojačivač ili kao antiretrovirusni lijek
English: Tipranavir 500 mg twice daily with ritonavir 200 mg twice daily.
Croatian: Tipranavir 500 mg dva puta na dan s ritonavirom 200 mg dva puta na dan.
English: The concomitant use of ritonavir is not recommended due to potential increase in vorapaxar exposure (see section 4.5).
Croatian: Ne preporučuje se istodobna primjena ritonavira jer može doći do povećanja izloženosti vorapaksaru (vidjeti dio 4.5).
English: When used with ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent, the lowest possible doses of atorvastatin or rosuvastatin should be administered.
Croatian: Kada se daju istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom ili kao s farmakokinetičkim pojačivačem, atorvastatin ili rosuvastatin treba davati u najmanjim mogućim dozama.
English: It is advisable to monitor renal function in patients with renal function impairment.
Croatian: Savjetuje se praćenje bubrežne funkcije u bolesnika u kojih je ona oslabljena.
English: Ritonavir dosed as an antiretroviral agent
Croatian: Ritonavir doziran kao antiretrovirusni lijek
English: • pain in the throat
Croatian: • bol u zglobovima i leđima
English: Ritonavir doses higher than 100 mg twice daily have not been studied with darunavir.
Croatian: Ritonavir u dozama većima od 100 mg dva puta na dan nije ispitan u kombinaciji s darunavirom.
English: morphine and morphine-like medicines used to treat severe pain (e.g. methadone, fentanyl); sleeping pills (e.g. alprazolam, zolpidem) and also midazolam administered by injection; tranquillisers (e.g. haloperidol, risperidone, thioridazine); colchicine, a treatment for gout.
Croatian: - imunosupresive (npr. ciklosporin, takrolimus, everolimus); - levotiroksin (primjenjuje se za liječenje problema sa štitnjačom) - morfin i njemu slične lijekove, koji se koriste za liječenje jake boli (npr. metadon, fentanil); - pilule za spavanje (npr. alprazolam, zolpidem) i midazolam u injekcijama; - trankvilizatore (npr. haloperidol, risperidon, tioridazin); - kolhicin, lijek za liječenje gihta.
English: Hypromellose Titanium dioxide (E171) Macrogols
Croatian: - Ovojnicu tablete čine: hipromeloza, titanijev dioksid (E171), makrogoli, hidroksipropilceluloza,
English: Serum levels of ritonavir may be affected by select co-administered medicinal products (e.g. delavirdine, efavirenz, phenytoin and rifampicin).
Croatian: Istodobna primjena nekih lijekova (npr. delavirdina, efavirenza, fenitoina i rifampicina) može utjecati na serumske razine ritonavira.
English: When ritonavir is used as a pharmacokinetic enhancer with other protease inhibitors the Summary of Product Characteristics for the particular protease inhibitor must be consulted.
Croatian: Kada se ritonavir koristi kao farmakokinetički pojačivač u kombinaciji s drugim inhibitorima proteaza, treba pročitati Sažetak opisa svojstava lijeka za taj određeni inhibitor proteaza.
English: For further information, physicians should refer to the Summary of Product Characteristics for atazanavir.
Croatian: Daljnje informacije liječnik treba potražiti u Sažetku opisa svojstava lijeka za atazanavir.
English: When ritonavir is used as a pharmacokinetic enhancer, full details on the warnings and precautions relevant to that particular PI must be considered, therefore the Summary of Product Characteristics, section 4.4, for the particular PI must be consulted to determine if the information below is applicable.
Croatian: nužno je potanko se upoznati sa svim upozorenjima i mjerama opreza za određeni IP te stoga mora pročitati njihov Sažetak opisa svojstava lijeka i dio 4.4, da se vidi vrijede li niže navedene informacije.
English: Clinical trials confirmed the safety and efficacy of fosamprenavir 700 mg twice daily with ritonavir 100 mg twice daily.
Croatian: Klinička su ispitivanja potvrdila neškodljivost i djelotvornost fosamprenavira u dozi od 700 mg dva puta na dan s ritonavirom u dozi od 100 mg dva puta na dan.
English: Life-threatening and fatal drug interactions have been reported in patients treated with colchicine and strong inhibitors of CYP3A like ritonavir (see sections 4.3 and 4.5).
Croatian: U bolesnika liječenih kolhicinom i snažnim inhibitorima CYP3A poput ritonavira zabilježene su po život opasne i fatalne interakcije lijekova (vidjeti dijelove 4.3 i 4.5).
English: When used with ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent, the lowest doses of atorvastatin or rosuvastatin should be administered.
Croatian: Kada se daju istodobno s ritonavirom kao farmakokinetičkim pojačivačem ili kao s antiretrovirusnim sredstvom, atorvastatin ili rosuvastatin treba davati u najmanjim dozama.
English: NAME OF THE MEDICINAL PRODUCT Ritonavir Mylan 100 mg film-coated tablets ritonavir
Croatian: Ritonavir Mylan 100 mg filmom obložene tablete ritonavir
English: The concomitant use of ritonavir is not recommended due to potential increase in riociguat exposure (see section 4.5).
Croatian: Ne preporučuje se istodobna primjena ritonavira jer može doći do povećanja izloženosti riocigvatu (vidjeti dio 4.5).
English: The Summary of Product Characteristics of other protease inhibitors or official continuous updates should be consulted for specific information regarding protease mutations associated with reduced response to these agents.
Croatian: Specifične informacije o mutacijama gena za proteaze povezanih sa smanjenim odgovorom na određene inhibitore proteaza treba potražiti u Sažetku opisa svojstava lijeka ili službenim ažuriranim podacima za te lijekove.
English: The co-administration of vorapaxar with ritonavir is not recommended (see section 4.4 and refer to the vorapaxar SmPC).
Croatian: Istodobna primjena vorapaksara i ritonavira se ne preporučuje (vidjeti dio 4.4 i Sažetak opisa svojstava lijeka za vorapaksar).
English: Clinical trials confirmed the safety and efficacy of 600 mg amprenavir twice daily with ritonavir 100 mg twice daily.
Croatian: Klinička su ispitivanja potvrdila neškodljivost i djelotvornost amprenavira u dozi od 600 mg dva puta na dan s ritonavirom u dozi od 100 mg dva puta na dan.
English: Thereby, increasing the risk of arrhythmias or other serious adverse effects from these agents.
Croatian: Time se povećava rizik od aritmija i od ostalih ozbiljnih nuspojava tih lijekova.
English: More frequent electrocardiogram monitoring and monitoring of transaminases is recommended (see section 4.5 and refer to the bedaquiline Summary of Product Characteristics).
Croatian: Preporučuje se učestalije praćenje elektrokardiograma i transaminaza (vidjeti dio 4.5 te Sažetak opisa svojstava lijeka za bedakilin).
English: 200 q12 h,
Croatian: 200 svakih 12 h,
English: Co-administration of abemaciclib and ritonavir should be avoided.
Croatian: Potrebno je izbjegavati istodobnu primjenu abemacikliba i ritonavira.
English: Increased plasma concentrations of lurasidone which may increase the potential for serious and/or life-threatening reactions (see section 4.5).
Croatian: Povećane koncentracije lurasidona u plazmi, što može povećati mogućnost nastupa ozbiljnih i/ili po život opasnih reakcija (vidjeti dio 4.5).
English: Increased plasma concentrations of clorazepate, diazepam, estazolam, flurazepam, oral midazolam and triazolam.
Croatian: Povećane koncentracije klorazepata, diazepama, estazolama, flurazepama, oralnog midazolama i triazolama u plazmi.
English: The dose of ritonavir may need adjusting.
Croatian: Nakon prekida uzimanja gospine trave, razine ritonavira mogu se povisiti pa će možda biti potrebno prilagoditi dozu.
English: Clorazepate, diazepam, estazolam, flurazepam, oral midazolam and triazolam
Croatian: Klorazepat, diazepam, estazolam, flurazepam, oralni midazolam i triazolam
English: Increased plasma concentrations of neratinib which may increase the potential for serious and/or life-threatening reactions including hepatotoxicity (see section 4.5).
Croatian: Povećane koncentracije neratiniba u plazmi, što može povećati mogućnost nastupa ozbiljnih i/ili po život opasnih reakcija, uključujući hepatotoksičnost (vidjeti dio 4.5).
English: Medicinal product interactions - Ritonavir with antiretroviral agents other than protease inhibitors
Croatian: Interakcije lijekova - ritonavir s antiretroviroticima koji nisu inhibitori proteaza Istodobno primijenjeni lijek