FrancophonIA/ELRC3.0 huggingface dataset:
English: The safety and efficacy of Opatanol in children aged under 3 years has not been established.
Croatian: Sigurnost i djelotvornost Opatanola u djece u dobi ispod 3 godine starosti nisu ustanovljene.
English: Other medicines and Opatanol
Croatian: Drugi lijekovi i Opatanol
English: Approximately 60-70% of the dose was recovered in the urine as active substance.
Croatian: Oko 60 - 70% primijenjene doze nađe se u urinu u obliku djelatne tvari.
English: Opatanol may be used in paediatric patients three years of age and older at the same dose as in adults.
Croatian: Opatanol se smije davati pedijatrijskim bolesnicima u dobi od tri godine i starijima u dozi jednakoj kao u odraslih.
English: The following adverse reactions have been reported during clinical studies and post-marketing data and are classified according to the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1000)very rare (<1/10,000) or not known (cannot be estimated from the available data).
Croatian: Niže navedene nuspojave zabilježene su u kliničkim ispitivanjima i praćenju nakon stavljanja lijeka u promet i razvrstane su prema sljedećoj učestalosti: vrlo često (≥ 1/10), često (≥1/100 do 1≤1/10), manje često (≥1/1000 do ≤1/100), rijetko (≥1/10 000 do ≤1/1000), vrlo rijetko (≤1/10 000) ili nepoznato (ne može se procijeniti iz dostupnih podataka).
English: Do not use Opatanol in children under the age of 3 years.
Croatian: Ne primjenjujte Opatanol kod djece mlađe od 3 godine.
English: Approximately 4.5% of patients can be expected to experience adverse reactions associated with the use of Opatanol; however, only 1.6% of patients discontinued from the clinical studies due to these adverse reactions.
Croatian: Opatanola se mogu očekivati u oko 4,5% bolesnika, međutim, samo je 1,6% bolesnika prekinulo sudjelovanje u kliničkim istraživanjima zbog navedenih nuspojava.
English: However, if it is almost time for your next dose, skip the missed dose before going back to your regular dosing routine.
Croatian: Ako je uskoro vrijeme za Vašu sljedeću dozu, propustite preskočenu dozu prije nego se vratite uobičajenom rasporedu primjene.
English: Opatanol has no or negligible influence on the ability to drive and use machines.
Croatian: Opatanol ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada na strojevima.
English: The following side effects have been seen with Opatanol:
Croatian: Sljedeće nuspojave zabilježene su s Opatanolom:
English: Do not use this medicine after the expiry date which is stated on the bottle and the box after ‘EXP'.
Croatian: Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na bočici i na kutiji iza oznake “EXP”.
English: Olopatadine has a low order of acute toxicity in animals.
Croatian: Olopatadin je iskazao nizak stupanj akutne toksičnosti u životinja.
English: Olopatadine is not recommended during pregnancy and in women of childbearing potential not using contraception.
Croatian: Primjena Opatanola se ne preporučuje tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju.
English: The most frequent treatment-related adverse reaction was eye pain, reported at an overall incidence of 0.7%.
Croatian: Najčešće prijavljivana nuspojava, povezana s uzimanjem lijeka, bila je bol u oku, čija je ukupna incidencija iznosila 0,7%.
English: If signs of serious reactions or hypersensitivity occur, discontinue the use of this treatment.
Croatian: Pojave li se znaci ozbiljnih reakcija ili preosjetljivosti, uzimanje lijeka treba prekinuti.
English: In vitro studies have shown that olopatadine did not inhibit metabolic reactions which involve cytochrome P-450 isozymes 1A2, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4.
Croatian: Istraživanja in vitro su pokazala da olopatadin nije inhibirao metaboličke reakcije u kojima sudjeluju izoenzimi 1A2, 2C8, 2C9, 2C19, 2D6, 2E1 i 3A4 citokroma P-450.
English: In clinical studies involving 1680 patients, Opatanol was administered one to four times daily in both eyes for up to four months as monotherapy or adjunctive therapy to loratadine 10 mg.
Croatian: U kliničkim istraživanjima koja su obuhvatila oko 1680 bolesnika, Opatanol se kapao u oba oka jedan do četiri puta na dan do četiri mjeseca, pri čemu se davao ili kao monoterapija ili kao dodatna terapija uz loratadin 10 mg.
English: These concentrations are 50-to 200-fold lower than those following well tolerated oral doses.
Croatian: Te su koncentracije 50 do 200 puta manje od peroralno primijenjenih doza koje se dobro podnose.
English: Shelf-life after first opening
Croatian: Rok valjanosti nakon prvog otvaranja
English: What Opatanol contains - The active substance is olopatadine.
Croatian: Što Opatanol sadrži - Djelatna tvar je olopatadin.
English: Studies in animals have shown reproductive toxicity following systemic administration (see section 5.3).
Croatian: Studije na životinjama pokazale su reproduktivnu toksičnost nakon sustavne primjene (vidjeti u dijelu 5.3).
English: However, no dosage adjustment is expected to be necessary in hepatic or renal impairment (see section 5.2).
Croatian: Međutim, ne očekuje se da bi pri oslabljenoj funkciji jetre ili bubrega dozu trebalo prilagođavati (vidjeti dio 5.2).
English: As with any eye drop, temporary blurred vision or other visual disturbances may affect the ability to drive or use machines.
Croatian: Kao i kad je riječ o bilo kojim kapima za oči, privremeno zamućen vid ili drugi poremećaj vida mogu utjecati na sposobnost upravljanja vozilima i rada na strojevima.
English: In the case of overdose, appropriate monitoring and management of the patient should be implemented.
Croatian: U slučaju predoziranja, bolesnika treba primjereno zbrinuti i pratiti.
English: Some materials (allergens) like pollens, house dust or animal fur may cause allergic reactions resulting in itching, redness as well as swelling of the surface of your eye.
Croatian: Neke tvari (alergeni), kao što su cvjetni pelud, kućna prašina ili životinjske dlake, mogu izazvati alergijsku reakciju koja se očituje pojavom svrbeža, crvenila kao i oticanja površine oka.
English: Use this much unless your doctor tells you to do differently.
Croatian: Primijenite ovu količinu osim u slučaju da Vas je liječnik savjetovao drugačije.
English: To prevent contamination of the dropper tip and solution, care must be taken not to touch the eyelids, surrounding areas, or other surfaces with the dropper tip of the bottle.
Croatian: Radi prevencije kontaminacije vrha kapaljke i otopine, mora se paziti da se ne dotaknu vjeđe, okolna područja ili druge površine vrhom kapaljke bočice.
English: Not known dermatitis, erythema
Croatian: Nepoznato dermatitis, eritem
English: The results indicate that a somewhat higher plasma concentration can be expected with Opatanol in this population.
Croatian: Rezultati pokazuju da se u te populacije mogu očekivati donekle veće koncentracije u plazmi pri primjeni Opatanola.
English: Use a single drop as soon as you remember, and then go back to your regular dosing routine.
Croatian: Ukapajte jednu dozu čim se sjetite i nastavite s uobičajenim rasporedom primjene.
English: Opatanol is a medicine for treatment of allergic conditions of the eye.
Croatian: Opatanol je lijek za liječenje alergijskih bolesti oka.
English: Opatanol should only be used as an eye drop.
Croatian: Opatanol kapi se moraju primjeniti samo kao kapi za oči.
English: This exposure would result in a final dose of 0.5 mg/kg in a 10 kg infant, assuming 100% absorption.
Croatian: Pri toj bi izloženosti konačna doza iznosila 5 mg/kg u dojenčeta težine 10 kg, pod pretpostavkom da apsorpcija bude
English: Olopatadine in the form of eye drops (Opatanol) has not been studied in patients with renal or hepatic disease.
Croatian: Primjena olopatadina u obliku kapi za oko (Opatanol) nije proučena u bolesnika s bolestima bubrega ili jetre.
English: What you need to know before you use Opatanol
Croatian: Što morate znati prije nego počnete primjenjivati Opatanol
English: In very rare cases, some patients with severe damage to the clear layer at the front of the eye (the cornea) have developed cloudy patches on the cornea due to calcium build-up during treatment.
Croatian: U vrlo rijetkim slučajevima, neki su bolesnici s jakim oštećenjem prozirnog sloja na prednjem dijelu oka (rožnica) razvili zamućene mrlje na rožnici zbog nakupljanja kalcija tijekom liječenja.
English: Accidental ingestion of the entire contents of a bottle of Opatanol would deliver a maximum systemic exposure of 5 mg olopatadine.
Croatian: Nehotičnim gutanjem cijelog sadržaja bočice Opatanola, organizam bi sustavno bio izložen maksimalnoj količini od 5 mg olopatadina.
English: Available data in animals have shown excretion of olopatadine in milk following oral administration (for details see section 5.3).
Croatian: Dostupni podaci na životinjama pokazali su da se olopatadin izlučuje u mlijeko nakon oralne primjene (vidjeti dio 5.3 za detalje).
English: Keep this medicine out of the sight and reach of children.
Croatian: Lijek čuvajte izvan pogleda i djece.
English: Olopatadine is absorbed systemically, as are other topically administered medicinal products.
Croatian: Olopatadin se apsorbira sustavno kao i ostali topikalno primijenjeni lijekovi.
English: Olopatadine is a potent selective antiallergic/antihistaminic agent that exerts its effects through multiple distinct mechanisms of action.
Croatian: Olopatadin je snažan selektivni antialergik/antihistaminik, koji djeluje putem više različitih mehanizama.
English: Detailed information on this medicine is available on the European Medicines Agency web site: http://www.emea.europa.eu/
Croatian: Detaljne informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove: http://www.ema.europa.eu.
English: Not known dyspnoea, sinusitis
Croatian: Nepoznato dispneja, sinusitis
English: If you are using other eye drops or eye ointment medicines, leave at least 5 minutes between each medicine.
Croatian: Ako primjenjujete druge lijekove u obliku kapi za oko ili mast za oko, pričekajte najmanje 5 minuta između primjene svakog lijeka.
English: These results indicate that olopatadine is unlikely to result in metabolic interactions with other concomitantly administered active substances.
Croatian: Ti rezultati pokazuju da nije vjerojatno da bi olopatadin stupao u metaboličke interakcije pri istodobnoj primjeni s drugim djelatnim tvarima.
English: However, systemic absorption of topically applied olopatadine is minimal with plasma concentrations ranging from below the assay quantitation limit (<0.5 ng/ml) up to 1.3 ng/ml.
Croatian: Međutim, sustavna apsorpcija topikalno primijenjenog olopatadina je minimalna te se koncentracije u plazmi kreću od one koja je ispod donje granice osjetljivosti testa (< 0,5 ng/ml) do 1,3 ng/ml.
English: If blurred vision occurs at instillation, the patient must wait until the vision clears before driving or using machinery.
Croatian: Ako se nakon ukapavanja kapi vid zamuti, bolesnik mora pričekati da se vid razbistri prije nego upravlja vozilom ili radi na stroju.
English: Write down the date you opened it in the space on each bottle label and box.
Croatian: Zapišite datum otvaranja na za to predviđeno mjesto na naljepnici bočice i na kutiji.
English: Avoid contact with soft contact lenses.
Croatian: Kontakt s mekim kontaktnim lećama mora se izbjegavati.
English: Since olopatadine is excreted in urine primarily as unchanged active substance, impairment of renal function alters the pharmacokinetics of olopatadine with peak plasma concentrations 2.3-fold greater in patients with severe renal impairment (mean creatinine clearance of 13.0 ml/min) compared to healthy adults.
Croatian: Budući da se olopatadin izlučuje u urin prvenstveno u obliku nepromijenjene djelatne tvari, oštećena funkcija bubrega utječe na farmakokinetiku olopatadina, pri čemu su njegove vršne koncentracije u plazmi 2,3 puta veće u bolesnika s teškim bubrežnim oštećenjem (srednja vrijednost klirensa kreatinina 13,0 ml/min) u usporedbi sa zdravim odraslim osobama.
English: Opatanol contains Benzalkonium chloride
Croatian: Opatanol sadrži benzalkonijev klorid
English: Studies comparing the pharmacokinetics of 10 mg oral doses of olopatadine in young (mean age 21 years) and elderly (mean age 74 years) showed no significant differences in the plasma concentrations (AUC), protein binding or urinary excretion of unchanged parent drug and metabolites.
Croatian: Istraživanja u kojima se uspoređivala farmakokinetika peroralno uzetog olapatadina u dozi od 10 mg u mladih (srednja dob 21 godinu) i starijih (srednja dob 74 godine) ispitanika, pokazala su da između dviju skupina nije bilo značajnih razlika u koncentracijama u plazmi (AUC), vezanju na proteine ni u izlučivanju nepromijenjene matične tvari ni metabolita u urin.
English: Benzalkonium chloride has also been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy.
Croatian: Objavljeno je da benzalkonijev klorid, može izazvati točkastu keratopatiju i/ili toksičnu ulceroznu keratopatiju.
English: Do not use Opatanol
Croatian: Nemojte uzimati Opatanol
English: Olopatadine has been detected in the milk of nursing rats following oral administration.
Croatian: Olopatadin se izlučivao u mlijeko ženki štakora nakon oralne primjene.
English: Common (may affect up to 1 in 10 people) Effects in the eye:
Croatian: Česte (mogu se pojaviti u manje od 1 na 10 osoba) Nuspojave na oku
English: This medicine contains 0.5 mg benzalkonium chloride in each 5 ml which is equivalent to 0.1 mg/ml.
Croatian: Ovaj lijek sadrži 0,1 mg benzalkonijevog klorida u svakom ml, što odgovara 0,1 mg/ml.
English: You should remove contact lenses that are in your eyes before using Opatanol.
Croatian: Morate skinuti kontaknte leće s oka prije primjene Opatanola.
English: 5 ml opaque low density polyethylene bottles with polypropylene screw caps (DROP-TAINER).
Croatian: Neprozirne bočice od polietilena niske gustoće volumena 5 ml s polipropilenskim zatvaračem s navojem (DROP-TAINER).
English: Patients should be instructed to remove contact lenses prior to administration of the eye drop and wait at least15 minutes after instillation before re-inserting contact lenses.
Croatian: Bolesnike treba uputiti da izvade kontaktne leće prije primjene kapi za oko i pričekaju najmanje 15 minuta nakon primjene prije negoli ponovno stave kontaktne leće.
English: Studies in animals have shown reduced growth of nursing pups of dams receiving systemic doses of olopatadine well in excess of the maximum level recommended for human ocular use.
Croatian: Ispitivanja na životinjama pokazala su na smanjen rast dojenih mladunaca u štakorica koje su primale sistemske doze olopatadina koje su znatno iznad preporučene razine za okularnu primjenu kod ljudi.
English: Eye ointments should be administered last.
Croatian: Mast za oko treba primijeniti posljednju.
English: Opatanol should not be used during breast-feeding.
Croatian: Opatanol se ne bi trebao primjenjivati tijekom dojenja.
English: Warnings and precautions Talk to your doctor or pharmacist before using Opatanol.
Croatian: Obratite se svom liječniku ili ljekarniku prije nego primijenite Opatanol.
English: From oral pharmacokinetic studies, the half-life of olopatadine in plasma was approximately eight to 12 hours, and elimination was predominantly through renal excretion.
Croatian: Farmakokinetička istraživanja nakon peroralne primjene pokazala su da je poluvijek olopatadina u plazmi oko 8 - 12 sati, a eliminacija je uglavnom izlučivanjem putem bubrega.
English: • Don't touch your eye or eyelid, surrounding areas or other surfaces with the dropper.
Croatian: • Izbjegavajte dodir kapaljke s okom ili vjeđama, okolnim područjima ili drugim površinama.
English: If you forget to use Opatanol
Croatian: Ako ste zaboravili primijeniti Opatanol
English: Use in elderly No dosage adjustment in elderly patients is necessary.
Croatian: U starijih bolesnika dozu ne treba prilagođavati.
English: The range of peak steady-state olopatadine plasma concentrations (35 to 127 ng/ml) seen in this study represents at least a 70-fold safety margin for topical olopatadine with respect to effects on cardiac repolarisation.
Croatian: Raspon vršnih oncentracija olopatadina u plazmi u stanju dinamičke ravnoteže (35 do 127 ng/ml), uočenih u tome istraživanju, pokazuje najmanje 70 puta veći sigurnosni prag pri površinskoj primjeni olopatadina, s obzirom na repolarizaciju srčanog mišića.
English: It antagonises histamine (the primary mediator of allergic response in humans) and prevents histamine induced inflammatory cytokine production by human conjunctival epithelial cells.
Croatian: Djeluje antagonistički na histamin (primarni medijator alergijskog odgovora u ljudi) i sprječava stvaranje upalnih citokina u epitelnim stanicama konjunktive, potaknuto djelovanjem histamina.
English: Treatment of ocular signs and symptoms of seasonal allergic conjunctivitis.
Croatian: Liječenje okularnih znakova i simptoma sezonskog alergijskog konjunktivitisa.
English: How to use Opatanol (continued)
Croatian: Kako primjenjivati Opatanol (nastavak)
English: If you stop using Opatanol Do not stop using this medicine without first speaking to your doctor.
Croatian: Nemojte prestati s primjenom ovog lijeka a da niste razgovarali s Vašim liječnikom.
English: Cases of corneal calcification have been reported very rarely in association with the use of phosphate containing eye drops in some patients with significantly damaged corneas.
Croatian: Slučajevi kalcifikacije rožnice prijavljeni su vrlo rijetko vezano uz primjenu kapi za oči koje sadrže fosfate u nekih bolesnika sa značajnijim oštećenjima rožnice.
English: Opatanol is used for the treatment of signs and symptoms of seasonal allergic conjunctivitis.
Croatian: Opatanol se koristi za liječenje znakova i simptoma sezonskog alergijskog konjunktivitisa.
English: Prolongation of the QTc interval in dogs was observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use.
Croatian: U pasa je uočeno produženje intervala QTc, no samo pri izloženosti znatno većoj od najveće izloženosti u čovjeka, što pokazuje da je značaj toga u kliničkoj primjeni malen.
English: The preservative in Opatanol, benzalkonium chloride, may be absorbed by soft contact lenses and may change the colour of the contact lenses.
Croatian: Konzervans u Opatanolu, benzalkonijev klorid, mogu apsorbirati meke kontaktne leće zbog čega se može promijeniti njihova boja.
English: • Gently press on the base of the bottle to release one drop of Opatanol at a time.
Croatian: • Laganim pritiskom kažiprsta na dno okrenute bočice istisnite po jednu kapljicu lijeka Opatanol.
English: Effects in the eye
Croatian: Poremećaji oka
English: Opatanol contains benzalkonium chloride which may cause eye irritation.
Croatian: Opatanol sadrži benzalkonijev klorid koji može nadražiti oko.
English: Studies have not been performed to evaluate the effect of topical ocular administration of olopatadine on human fertility.
Croatian: Nisu provedene studije procjene utjecaja lokalne okularne primjene olopatadina na plodnost u ljudi.
English: What Opatanol looks like and contents of the pack Opatanol is a clear and colourless liquid (a solution) supplied in a pack containing either one 5 ml bottle or three 5 ml plastic bottles with screw caps.
Croatian: Opatanol je bistra i bezbojna tekućina (otopina) dostupna u pakovanju ili s jednom bočicom od 5 ml ili s tri plastične bočice od 5 ml sa zatvaračem s navojem.
English: Benzalkonium chloride sodium chloride disodium phosphate dodecahydrate (E339) hydrochloric acid (E507) (to adjust pH) sodium hydroxide (E524) (to adjust pH) purified water
Croatian: Benzalkonijev klorid natrijev klorid natrijev hidrogenfosfat dodekahidrat (E339) kloridna kiselina(E507) (za podešavanje pH) natrijev hidroksid (E524) (za podešavanje pH) pročišćena voda
English: A 5 mg oral dose was administered twice-daily for 2.5 days to 102 young and elderly male and female healthy volunteers with no significant prolongation of QTc interval compared to placebo.
Croatian: U 102 mlađa i starija zdrava dragovoljca obaju spolova, koji su primali peroralno po 5 mg dva puta na dan tijekom dva i pol dana, nije uočeno značajno produženje intervala QTc u usporedbi s placebom.
English: Two metabolites, the mono-desmethyl and the Noxide, were detected at low concentrations in the urine.
Croatian: U urinu su dokazana i dva metabolita, monodezmetil i N-oksid, no u niskim koncentracijama.
English: Alcon Cusí, S.A. Camil Fabra 58 08320 El Masnou Spain
Croatian: Camil Fabra 58 08320 El Masnou Španjolska
English: You should not use Opatanol if you are breast-feeding, ask your doctor for advice before using this medicine.
Croatian: Ako dojite ne koristite Opatanol, obratite se svom liječniku za savjet prije primjene ovog lijeka.
English: Since plasma concentrations following topical ocular dosing of olopatadine are 50-to 200-fold lower than after well-tolerated oral doses, dose adjustment is not expected to be necessary in the elderly or in the renally impaired population.
Croatian: Budući da su koncentracije olopatadina u plazmi nakon njegove topikalne okularne primjene 50 do 200 puta manje od peroralnih doza koje se dobro podnose, očekuje se da u starijih osoba, kao i u onih s oštećenom funkcijom bubrega, dozu ne treba prilagođavati.
English: Data from in vitro studies suggest that it may act on human conjunctival mast cells to inhibit the release of pro-inflammatory mediators.
Croatian: Podaci dobiveni istraživanjima in vitro pokazuju da bi olopatadin mogao djelovati na mastocite u ljudskoj konjunktivi i tako inhibirati oslobađanje proupalnih medijatora.
English: There are no or limited amount of data from the use of ophthalmic olopatadine in pregnant women.
Croatian: Nema podataka ili su podaci o okularnoj primjeni olopatadina u trudnica ograničeni.
English: It does not produce a clinically significant change in pupil diameter.
Croatian: Ne utječe klinički značajno na promjer zjenice.
English: • Put the bottle cap back on firmly immediately after use.
Croatian: • Poklopac bočice dobro zatvorite odmah nakon primjene.
English: No data are available in humans regarding overdose by accidental or deliberate ingestion.
Croatian: Nema podataka o slučajnom ili namjernom predoziranju ingestijom u ljudi.
English: Not known nausea, vomiting,
Croatian: Nepoznato mučnina, povraćanje
English: Benzalkonium chloride, sodium chloride, disodium phosphate dodecahydrate, hydrochloric acid/sodium hydroxide and purified water.
Croatian: Benzalkonijev klorid, natrijev klorid, natrijev hidrogenfosfat dodekahidrat, kloridna kiselina/natrijev hidroksid i pročišćena voda.
English: Dose adjustment is not expected to be necessary with hepatic impairment.
Croatian: Stoga se ne očekuje da bi dozu trebalo prilagođavati u bolesnika s oštećenjem jetre.
English: After the bottle cap is removed, if the tamper evident snap collar is loose, remove before using the product.
Croatian: Nakon skidanja poklopca bočice, ukoliko je zaštitni obruč s evidencijom otvaranja klimav, uklonite ga prije primjene lijeka.
English: No serious ophthalmic or systemic adverse reactions related to Opatanol were reported in clinical studies.
Croatian: Tijekom kliničkih istraživanja nisu prijavljene ozbiljne oftalmičke ili sustavne nuspojave povezane s uzimanjem Opatanola.
English: Uncommon corneal erosion, corneal epithelium defect, corneal epithelium disorder, punctate keratitis, keratitis, corneal staining, eye discharge, photophobia, vision blurred, visual acuity reduced, blepharospasm, ocular discomfort, eye pruritus, conjunctival follicles, conjunctival disorder, foreign body sensation in eyes, lacrimation increased, erythema of eyelid, eyelid oedema, eyelid disorder, ocular hyperaemia
Croatian: Manje često erozija rožnice, defekt rožničnog epitela, poremećaj epitela rožnice, točkasti keratitis, keratitis, obojenje rožnice, iscjedak iz oka, fotofobija, zamućen vid, smanjena vidna oštrina, blefarospazam, neugodan osjećaj u oku, svrbež oka, konjunktivalni folikuli, poremećaj konjunktive, osjećaj stranog tijela u oku, pojačano suzenje, eritem vjeđa, edem vjeđa, poremećaj vjeđa, okularna hiperemija