FrancophonIA/ELRC3.0 huggingface dataset:
English: Concomitant administration of boosted darunavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity.
Croatian: darunavira i kvetiapina je kontraindicirana jer može povisiti toksičnost povezanu s kvetiapinom.
English: Atorvastatin 10 mg once daily atorvastatin AUC ↑ 3-4 fold atorvastatin Cmin ↑ ≈5.5-10 fold atorvastatin Cmax ↑ ≈2 fold darunavir/ritonavir
Croatian: Atorvastatin 10 mg jedanput na dan atorvastatin AUC ↑ 3-4 puta atorvastatin Cmin ↑ ≈5.5-10 puta
English: Amitriptyline Desipramine Imipramine Nortriptyline Trazodone paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
Croatian: Amitriptilin Dezipramin Imipramin Nortriptilin Trazodon paroksetin AUC ↓ 39% paroksetin Cmin ↓ 37% paroksetin Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49% sertralin Cmin ↓ 49% sertralin Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
English: 150 mg twice daily maraviroc AUC ↑ 305% maraviroc Cmin ND maraviroc Cmax ↑ 129% darunavir, ritonavir concentrations were
Croatian: 150 mg dvaput na dan maravirok AUC ↑ 305% maravirok Cmin ND maravirok Cmax ↑ 129% koncentracije darunavira, ritonavira bile su sukladne s
English: Concomitant use of other PDE-5 inhibitors for the treatment of erectile dysfunction with darunavir coadministered with low dose ritonavir should be done with caution.
Croatian: Mora se s oprezom istodobno primjenjivati druge inhibitore PDE-5 za liječenje erektilne disfunkcije s darunavirom primijenjenog istodobno s niskom dozom ritonavira.
English: -The other ingredients arecellulose,microcrystalline;crospovidone, hydroxypropylcellulose; silica, colloidal anhydrous; silicified microcrystalline cellulose(cellulose,microcrystalline; silica, colloidal anhydrous)and magnesium stearate (E470b)in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) -only for 400mgfilm-coated tablets and red iron oxide (E172)in film coating.
Croatian: - Drugi sastojci su mikrokristalična celuloza, krospovidon, hidroksipropilceluloza, koloidni bezvodni silicijev dioksid, silicificirana mikrokristalična celuloza (mikrokristalična celuloza, koloidni bezvodni silicijev dioksid) i magnezijev stearat (E470b) u jezgri tablete te poli(vinilni alkohol), makrogol, titanijev dioksid (E171), talk (E553b), žuti željezov oksid (E172)samo za 400 mg filmom obložene tablete i crveni željezov oksid (E172) u film ovojnici tablete.
English: ≥ 30 kg-< 40 kg 675 mg darunavir/100 mg ritonavir once daily
Croatian: ≥ 30 kg-< 40 kg 675 mg darunavir /100 mg ritonavir jedanput na dan
English: see section 4.5) sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5).
Croatian: avanafil - simvastatin, lovastatin i lomitapid (vidjeti dio 4.5) - dabigatran, tikagrelor (vidjeti dio 4.5).
English: Co-administration of darunavir and ritonavir and other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (e.g. indinavir azole antifungals like clotrimazole).
Croatian: Istodobna primjena darunavira i ritonavira i drugih lijekova koji inhibiraju CYP3A može smanjiti klirens darunavira i ritonavira te može rezultirati povišenjem koncentracija darunavira i ritonavira u plazmi (npr. indinavir, antifungalni azoli poput klotrimazola).
English: 400 and 800 milligram tablets are used to treat adults and children (3 years of age and above, at least 40 kilograms body weight) who are infected by HIV and who have not used antiretroviral medicines before.
Croatian: Tablete lijeka Darunavir Krka d.d. od 400 miligrama i 800 miligrama koriste se za liječenje odraslih i djece (u dobi od 3 godine i starije, tjelesne težine najmanje 40 kilograma) koji su zaraženi HIV-om i - prethodno nisu uzimali antiretrovirusne lijekove. - u pojedinih bolesnika koji su već prije koristili antiretrovirusne lijekove (to će ustanoviti Vaš liječnik).
English: that the lowest possible dose of digoxin should initially be prescribed in case digoxin is given to patients on darunavir/ritonavir therapy.
Croatian: Budući da digoksin ima uzak terapijski indeks, preporučuje se inicijalno propisati najnižu moguću dozu digoksina u slučaju kada se digoksin daje bolesnicima koji su na terapiji darunavirom/ritonavirom.
English: Darunavir/ritonavir N=12
Croatian: Ishodi u 48. tjednu darunavir/ritonavir N=12
English: with ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Croatian: Darunavir Krka d.d. s ritonavirom nije bio ispitan sa svim IP (inhibitori proteaze) i ne smije se uzimati s drugim IP HIV-a.
English: 800 mg film-coated tablets are available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets) and 90 film-coated tablets (3 bottles of 30 film-coated tablets) in a box.
Croatian: Darunavir Krka d.d. 800 mg filmom obložene tablete dostupne su u bočicama koje sadrže 30 filmom obloženih tableta (1 bočica s 30 filmom obloženih tableta) i 90 filmom obloženih tableta (3 bočice s 30 filmom obloženih tableta) u kutiji.
English: may still develop infections or other illnesses associated with HIV infection.
Croatian: Osobe koje uzimaju Darunavir Krka d.d. i dalje mogu razvijati infekcije ili druge bolesti povezane s HIV infekcijom.
English: In the morning, take one 600 milligram Darunavir Krkad.d.tablettogether with 100 milligram ritonavir.
Croatian: - Ujutro uzmite jednu tabletu lijeka Darunavir Krka d.d. od 600 miligrama zajedno sa 100 miligrama ritonavira.
English: A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function
Croatian: Ako je potrebno liječenje pojačanim darunavirom, preporučuje se smanjiti dozu kolhicina ili prekinuti liječenje kolhicinom u bolesnika s normalnom funkcijom bubrega ili jetre.
English: Darunavir Krka d.d., co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection.
Croatian: Darunavir Krka d.d., primijenjen istodobno s niskom dozom ritonavira, indiciran je u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje bolesnika koji su inficirani virusom humane imunodeficijencije (HIV-1).
English: #, a comparable systemic exposure to sildenafil was observed for a single intake of 100 mg sildenafil alone and a single intake of 25 mg sildenafil co-administered with darunavir and low dose ritonavir.
Croatian: U ispitivanju interakcija primijećena je usporediva sistemska izloženost sildenafilu unosom jednokratne doze od 100 mg samo sildenafila i unosa jednokratne doze od 25 mg sildenafila istodobno primijenjenog s darunavirom i niskom dozom ritonavira.
English: Clinical monitoring is recommended when co-administering darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered.
Croatian: pojačan darunavir s tim sedativima/hipnoticima i u obzir treba uzeti nižu dozu sedativa/hipnotika.
English: every day and always in combination with 150 milligram of cobicistat or 100 milligram of ritonavir and with food.
Croatian: Lijek Darunavir Krka d.d. morate uzimati svaki dan i uvijek u kombinaciji sa 150 mg kobicistata ili 100 miligrama ritonavira i s hranom.
English: with cobicistat or ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs.
Croatian: Darunavir Krka d.d. s kobicistatom ili ritonavirom nije bio ispitan sa svim IP (inhibitori proteaze) i ne smije se uzimati s drugim IP HIV-a.
English: The dosage of other medicines might need to be changed since either their own or Darunavir Krka d.d.
Croatian: Postoji mogućnost da će biti potrebno promijeniti doziranje drugih lijekova, s obzirom na mogućnost promjene terapijskog učinka ili nuspojava tih lijekova ili lijeka Darunavir Krka d.d. kada se primjenjuju u kombinaciji.
English: Skin and subcutaneous tissue disorders common rash (including macular, maculopapular, papular, erythematous and pruritic rash), pruritus uncommon angioedema, generalised rash, allergic dermatitis, urticaria, eczema, erythema, hyperhidrosis, night sweats, alopecia, acne, dry skin, nail pigmentation rare
Croatian: Poremećaji kože i potkožnog tkiva često osip (uključujući makularni, makulopapularni, papularni, eritematozni i osip koji svrbi), pruritus manje često angioedem, generalizirani osip, alergijski dermatitis, urtikarija, ekcem, eritem, hiperhidroza, noćna znojenja, alopecija, akne, suha koža, pigmentacija noktiju
English: Each film-coated tablet contains 400mg or 800mg darunavir.
Croatian: Jedna filmom obložena tableta sadrži 400 mg ili 800 mg darunavira.
English: Based on theoretical considerations darunavir is expected to increase alfuzosin plasma concentrations.
Croatian: Temeljeno na teorijskim postavkama očekuje se da će darunavir povećati koncentracije alfuzozina u plazmi. (CYP3A inhibicija)
English: In the evening, take one 600 milligram Darunavir Krkad.d.tablettogether with 100 milligram ritonavir.
Croatian: - Navečer uzmite jednu tabletu lijeka Darunavir Krka d.d. od 600 miligrama zajedno sa 100 miligrama ritonavira.
English: Caution should be exercised when combining one of these antineoplastic agents with darunavir with low dose ritonavir.
Croatian: Potreban je oprez kada se neki od tih antineoplastika kombinira s darunavirom primijenjenim s niskom dozom ritonavira.
English: Skin and subcutaneous tissue disorders very common rash (including macular, maculopapular, papular, erythematous, pruritic rash, generalised rash, and allergic dermatitis)
Croatian: Nuspojava vrlo često osip (uključujući makularni, makulopapularni, papularni, eritematozni, pruritički osip, generalizirani osip i alergijski dermatitis)
English: The doctor will inform you on how many Darunavir Krka d.d.
Croatian: Liječnik će Vas informirati koliko Darunavir Krka d.d. tableta dijete mora uzeti.
English: 800 milligram Darunavir Krka d.d.
Croatian: Darunavir Krka d.d. 800 mg
English: works by reducing the amount of HIV in your body.
Croatian: Darunavir Krka d.d. djeluje tako da smanjuje količinu virusa HIV-a u Vašem tijelu.
English: When administration of atorvastatin and darunavir co-administered with low dose ritonavir is desired, it is recommended to start with an atorvastatin dose of 10 mg once daily.
Croatian: Kada se želi primijeniti atorvastatin i darunavir atorvastatin Cmax ↑ ≈2 puta darunavir/ritonavir primijenjen istodobno s niskom dozom ritonavira, preporučuje se početi s dozom atorvastatina od 10 mg jedanput na dan.
English: Darunavir Krka d.d., co-administered with cobicistat is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection in adult patients (see section 4.2).
Croatian: Darunavir Krka d.d., primijenjen istodobno s kobicistatom, indiciran je u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje infekcije virusom humane imunodeficijencije (HIV-1) u odraslih bolesnika (vidjeti dio 4.2).
English: The use of darunavir co-administered with low dose ritonavir and these anticoagulants is not recommended.
Croatian: primjena primjena darunavira istodobno primijenjenog s niskom dozom ritonavira i ovih antikoagulansa.
English: Darunavir Krka d.d., co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection (see section 4.2).
Croatian: Darunavir Krka d.d., primijenjen istodobno s niskom dozom ritonavira, indiciran je u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje bolesnika koji su inficirani virusom humane imunodeficijencije (HIV-1) (vidjeti dio 4.2).
English: 600 mg darunavir/100 mg ritonavir twice daily ritonavir oral solution: 80 mg/ml
Croatian: 600 mg darunavir /100 mg ritonavir dvaput na dan oralna otopina ritonavira: 80 mg/ml
English: Ethinylestradiol Norethindrone 35 μg/1 mg once daily drospirenone AUC ↑ 58% drospirenone Cmin ND drospirenone Cmax ↑ 15%
Croatian: Etinilestradiol drospirenon AUC ↑ 58% drospirenon Cmin NO drospirenon Cmax ↑ 15%
English: 30 film-coated tablets: EU/1/17/1248/009 90 film-coated tablets: EU/1/17/1248/010
Croatian: 30 filmom obloženih tableta: EU/1/17/1248/009 90 filmom obloženih tableta: EU/1/17/1248/010
English: How to take Darunavir Krka d.d.
Croatian: Kako uzimati Darunavir Krka d.d.
English: ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC ↑ 57% clarithromycin Cmin ↑ 174% clarithromycin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17% 14-OH-clarithromycin concentrations were not detectable when combined with darunavir/ritonavir.
Croatian: ANTIBIOTICI Klaritromicin 500 mg dvaput na dan klaritromicin AUC ↑ 57% klaritromicin Cmin ↑ 174% klaritromicin Cmax ↑ 26% darunavir AUC ↓ 13% darunavir Cmin ↑ 1% darunavir Cmax ↓ 17% Koncentraciju 14-OHklaritromicina nije bilo moguće odrediti kada se kombinirao s darunavirom/ritonavirom. (↑klaritromicina zbog inhibicije CYP3A i moguće P-gp inhibicije)
English: In addition, patients on a stable dose of these antidepressants who start treatment with darunavir with low dose ritonavir should be monitored for antidepressant response.
Croatian: dozi tih antidepresiva koji započnu liječenje s darunavirom s niskom dozom ritonavira mora se pratiti na odgovor na antidepresive.
English: Therefore, therapy with darunavir/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with darunavir/cobicistat should be switched to an alternative regimen (see sections 4.4 and 4.6).
Croatian: Stoga se liječenje darunavirom/kobicistatom istat ne smije započinjati tijekom trudnoće, a žene koje zatrudne tijekom liječenja darunavirom/kobicistatom trebaju prijeći na zamjenski režim (vidjeti dijelove 4.4 i 4.6).
English: EU/1/17/1248/009 30 film-coated tablets EU/1/17/1248/010 90 film-coated tablets
Croatian: EU/1/17/1248/009 30 filmom obloženih tableta EU/1/17/1248/010 90 filmom obloženih tableta
English: Efficacy of darunavir 800 mg once daily co-administered with 150 mg cobicistat once daily in ARTnaïve and ART-experienced patients
Croatian: Djelotvornost darunavira od 800 mg jedanput na dan primijenjenog istodobno sa 150 mg kobicistata jedanput na dan u bolesnika prethodno neliječenih ART-om i u bolesnika prethodno liječenih ART-om
English: Therefore, therapy with darunavir/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with darunavir/cobicistat should be switched to an alternative regimen(see sections4.2 and 4.6).
Croatian: Stoga se liječenje darunavirom/kobicistatom ne smije započinjati tijekom trudnoće, a žene koje zatrudne tijekom liječenja darunavirom/kobicistatom trebaju prijeći na zamjenski režim (vidjeti dijelove 4.2 i 4.6).
English: Bottle (HDPE), child resistant temper evident PP closure with a desiccant: - 30 tablets: 1 bottle of 30 film-coated tablets, - 90 tablets: 3 bottles of 30 film-coated tablets.
Croatian: Bočica (HDPE), PP zatvarač s evidencijom otvaranja siguran za djecu sa sredstvom za sušenje: - 30 tableta: 1 bočica s 30 filmom obloženih tableta, - 90tableta:3 bočice s 30 filmom obloženih tableta.
English: Boosted darunavir may increase antifungal plasma concentrations and posaconazole, isavuconazole, itraconazole or fluconazole may increase darunavir concentrations.
Croatian: Pojačan darunavir može povećati koncentracije antifungika u plazmi, a posakonazol, izavukonazol, itrakonazol ili flukonazol mogu povećati koncentracije darunavira. (CYP3A inhibicija i/ili P-gp inhibicija)
English: (inhibition of CYP450 enzymes)
Croatian: darunavirom istodobno primijenjenim s kobicistatom. (inhibicija CYP450 enzima)
English: Body weight (kg)
Croatian: Body weight (kg) Doza (jedanput na dan s hranom)
English: 450 mg darunavir/60 mg ritonavir twice daily
Croatian: 450 mg darunavir /60 mg ritonavir dvaput na dan
English: Recommended dose for treatment-naïve paediatric patients (3 to 17 years) with darunavir tablets and ritonavir
Croatian: Preporučena doza darunavira i ritonavira a za pedijatrijske bolesnike (od 3 do 17 godina) koji su prethodno liječeni
English: For additional clinical study results in ART-experienced adults and paediatric patients, refer to the Summary of Product Characteristics for Darunavir Krka d.d.
Croatian: Rezultate dodatnih kliničkih ispitivanja u odraslih i pedijatrijskih bolesnika prethodno liječenih ART-om, vidjeti u sažetku opisa svojstava lijeka za Darunavir Krka d.d. 600 mg tablete.
English: For dosage recommendations in children, see the Summary of Product Characteristics for Darunavir Krka d.d.
Croatian: Za preporučena doziranja u djece, vidjeti sažetak opisa svojstava lijeka za Darunavir Krka d.d. 600 mg tablete.
English: 400 milligram and 800 milligram tablets are only to be used to construct the once daily 800 milligram regimen.
Croatian: Tablete Darunavir Krka d.d. od 400 miligrama i 800 miligrama primjenjuju se samo za dostizanje režima doziranja od 800 miligrama jedanput na dan.
English: Darunavir/ritonavirshould be used during pregnancy only if the potential benefit justifies the potential risk.
Croatian: Darunavir/ritonavir se tijekom trudnoće smiju uzimati samo ako potencijalna korist opravdava potencijalni rizik.
English: Treatment difference darunavir/ritonavir
Croatian: TITAN 48. tjedan darunavir/ritonavi
English: Indinavir 800 mg twice daily indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ darunavir AUC ↑ 24% darunavir Cmin ↑ 44% darunavir Cmax ↑ 11%
Croatian: Indinavir 800 mg dvaput na dan indinavir AUC ↑ 23% indinavir Cmin ↑ 125% indinavir Cmax ↔ darunavir AUC ↑ 24% darunavir Cmin ↑ 44% darunavir Cmax ↑ 11% Indinavir: usporedba indinavira/ritonavira 800/100 mg dvaput na dan naspram indinavira/darunavira/ritonavira 800/400/100 mg dvaput na dan.
English: 800 mg darunavir/100 mg ritonavir once daily ritonavir oral solution: 80 mg/ml
Croatian: 800 mg darunavir/100 mg ritonavir jedanput na dan oralna otopina ritonavira: 80 mg/ml
English: These are mentioned above under the heading ‘Do not combine Darunavir Krka d.d.
Croatian: Postoje neki lijekovi koje ne smijete kombinirati s lijekom Darunavir Krka d.d. Navedeni su gore pod naslovom „Nemojte kombinirati Darunavir Krka d.d. ni s jednim od sljedećih lijekova“.
English: Dabigatran Ticagrelor
Croatian: Dizopiramid Flekainid
English: Concomitant use of boosted darunavir and elbasvir/grazoprevir is contraindicated (see section 4.3).
Croatian: Istodobna primjena pojačanog darunavira s elbasvirom/grazoprevirom je kontraindicirana (vidjeti dio 4.3).
English: How to store Darunavir Krka d.d.
Croatian: Kako čuvati Darunavir Krka d.d.
English: 600 milligram Darunavir Krka d.d.
Croatian: Darunavir Krka d.d. 600 mg
English: Darunavir Krkad.d.must be taken in combination witha low dose of cobicistat or ritonavir andother anti-HIV medicines.
Croatian: Darunavir Krka d.d. se mora uzimati u kombinaciji s niskom dozom kobicistata ili ritonavira i drugim lijekovima protiv HIV-a.
English: 400 mg film-coated tablets are available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a box.
Croatian: Darunavir Krka d.d. 400 mg filmom obložene tablete dostupne su u bočicama koje sadrže 30 filmom obloženih tableta (1 bočica s 30 filmom obloženih tableta), 60 filmom obloženih tableta (2 bočice s 30 filmom obloženih tableta), 90 filmom obloženih tableta (3 bočice s 30 filmom obloženih tableta) i 180 filmom obloženih tableta (6 bočica s 30 filmom obloženih tableta) u kutiji.
English: If you notice within 12 hours, you must take the tablets immediately.
Croatian: Ako primijetite da niste uzeli lijek unutar 6 sati, tablete morate uzeti odmah, uvijek s ritonavirom i hranom.
English: alfuzosin amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine astemizole, terfenadine colchicine when used in patients with renal and/or hepatic impairment (see section ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine) elbasvir/grazoprevir cisapride dapoxetine domperidone naloxegol lurasidone, pimozide, quetiapine, sertindole (see section 4.5) triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
Croatian: (vidjeti dio 4.5) - ergot derivate (npr. dihidroergotamin, ergometrin, ergotamin, metilergonovin) - elbasvir/grazoprevir - cisaprid - dapoksetin - domperidon - naloksegol - lurasidon, pimozid, kvetiapin, sertindol (vidjetidio 4.5) - triazolam, peroralno primijenjen midazolam (mjere opreza za parenteralnu primjenu midazolama, vidjeti dio 4.5)
English: What is Darunavir Krka d.d.
Croatian: Što je Darunavir Krka d.d.?
English: The child must take Darunavir Krka d.d.
Croatian: - Dijete mora uzimati lijek Darunavir Krka d.d. s hranom.
English: is not for use in children younger than 3 years of age or weighing less than 15 kilograms.
Croatian: Darunavir Krka d.d. nije namijenjen za primjenu u djece mlađe od 3 godine ili tjelesne težine manje od 15 kilograma.
English: always together with 150 milligram of cobicistat or100 milligram of ritonavir.
Croatian: - Lijek Darunavir Krka d.d. uvijek uzimajte zajedno sa 150 mg kobicistata ili 100 miligrama ritonavira.
English: is available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets), 60 film-coated tablets (2 bottles of 30 film-coated tablets), 90 film-coated tablets (3 bottles of 30 film-coated tablets) and 180 film-coated tablets (6 bottles of 30 film-coated tablets) in a boxes.
Croatian: Darunavir Krka d.d. dostupne su u bočicama koje sadrže 30 filmom obloženih tableta (1 bočica s 30 filmom obloženih tableta), 60 filmom obloženih tableta (2 bočice s 30 filmom obloženih tableta), 90 filmom obloženih tableta (3 bočice s 30 filmom obloženih tableta) i 180 filmom obloženih tableta (6 bočica s 30 filmom obloženih tableta) u kutiji.
English: (induction of CYP450 enzymes) Concentrations of voriconazole may increase or decrease when co-administered with darunavir co-administered with cobicistat.
Croatian: Ritonavir može sniziti koncentracije vorikonazola u plazmi. (indukcija CYP450 enzima) Koncentracije vorikonazola mogu se povećati ili smanjiti kada se istodobno primijenjuje s
English: Iron oxide, yellow (E172) - only for 400 mg film-coated tablets Iron oxide, red (E172)
Croatian: poli(vinilni alkohol) makrogol titanijev dioksid (E171) talk (E553b) željezov oksid, žuti (E172) - samo u 400 mg filmom obloženim tabletama željezov oksid, crveni (E172)
English: All subjects darunavir/cobicistat 800/150 mg once daily + OBR N=313
Croatian: Svi ispitanici darunavir/kobicistat 800/150 mg jedanput na dan + OBR N=313
English: HIV-1 RNA < 50 copies/ml mean HIV-1 RNA log change from baseline (log10 copies/ml)
Croatian: HIV-1 RNK < 50 kopija/ml S početnom HIV-1 RNK (kopija/ml)
English: ART-experienced adult patients The recommended dose regimens are as follows: In ART-experienced patients with no darunavir resistance associated mutations (DRV-RAMs)* and who have plasma HIV-1 RNA < 100,000 copies/ml and CD4+ cell count ≥ 100 cells x 10
Croatian: Odrasli bolesnici prethodno liječeni ART-om Preporučeni režim doziranja je slijedeći: - U bolesnika prethodno liječenih ART-om, bez mutacija povezanih s rezistencijom na darunavir (DRV-RAM, od engl. darunavir resistance associated mutations)* a imaju plazmatsku HIV-1 RNK < 100 000 kopija/ml i broj CD4+ stanica ≥ 100 stanica x 10
English: 600 mg
Croatian: 100 miligrama